PharMolix/UniProtQA huggingface dataset:
Protein: PROT_BRATP
Sequence: MTVLDLSYNFANLSVHDLLEARDTYHYHLLSKANVVGTAIGLYLIRKDEAWPTRKGEGKTPPNKKTYARTLSNSEVRDYSWPCILAFVRSWANEDAFGPAGRYDPAQIVPKTLYLADGRAVPVCVVQADQAGSDTSATYSPPGILPAHKLGGGSPIIVRVQGAEYSATAGCLVSDGHLTYALTARHACGEADTRIFSYLRSGEVEIGASSANQLTRKPFSEVYPDFPGRRSYVALDVGLVRLDQVDDWTSNTYGLPPVGPLGDVHEKNLSLRLIDQPVLGRGATSGLVRGTIKALFYRYRSVGGYDYVGDFLISPAEGLATRHGDSGMVWHLDATTEDDAANPKPLPKRDLRPLAVAWGGQVFEESGVRSAFSIATSLSNVCKLLDVELVTDQSRGVSGYWGRTGHYSIAAFAVALVGDTDLRDFLNRNLGILSFDLDTIAEKGFDKSVGQLGDNFVPLADVPDEIWKKLDHGKNGREGGRDVSAGPHGSDGPEHPNHYADIDGEIGPHKTFRAACLADDSNLTVDAWLQYYETMAAKAKADGDEDGARRHRNKLKQGLLPFRVWQFFDAMVAFVENKDVVGFLTAAGAAAHYMGDASQPLHGSVYSDGDASRTVTRHHPRTGEDEEVSYGSGVHSAFETAMIADKAAQLFPLIKQELSGPGGHALPLLTSGKAMAKATVELMDKVAGILEPMRILDSYEQAGAGTRKATLDGMWKDLGDDTAQVMALGARYLAMLWESAWVHGKGSDIPVRNLTDQNPQDVRARYIQTSFVPSLTLDKIGDELT
What is the function of this protein?
Probably a dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death.  Involved in defense against bacteriophages (Probable).  Expression of gasdermin bGSDM and this neighboring protease is toxic in E. coli on solid medium (PubMed:35025633).
What are the official names of this protein?
Probable serine protease Ga0098714_109514.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: MENG_CHLCV
Sequence: MQLSTNKPDLQEMFDSLAPKYDRINSILSLGMHHLWNRKFSKMLGKSECLLDLCSGTGKVAYRYIHDYPKSQAILVDFSSNMLAIAKQRYPKAPFTFIEGDIAQLPIDQESHTLAAISYGLRNLPDRKNALNEIHRILKPNGCLGILELTSPSDNHPMYLAHRLYLKFLVPLIGRLCSKNKQAYHYLAESIKNLPKDDYLEQLFKDAQFQISKKRKFAFGAATIWILQKI
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: LPXK_RICAE
Sequence: MIKLLYPEFWQKRNIIAYLLLPISVIYQFLGYLRASLARPIMLPAKVICVGNCSVGGTGKTQIVMYLAKLLKARNVSFVIVTKAYGSNLTSATTIHQGHTALEVGDEGVILAKYGAVIATKNIKEIVPLLNELKPDIIIVDDFLQNPYFHKDFTIVSVDSQRLFGNGFLIPAGPLRQYPNKALDAADLIFLVSSHQDKIPNILTPYVNKLINAQIVPSNNIDKTKNYFAFSGIGNPERFFATLKNYGLNITGYKIFPDHYNYLQADLENLYSLAKEHNATLVTTRKDHVKFNDLNNNIVCLDVELSINHPDLLNEKIFKKA
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: DLTC_STAS1
Sequence: MEFRDQVLDLLTEVAETNVIKENPDVELFEEGIIDSFQTVGLLLEIQNKLDIEVSIMDFDRDEWATPNKIVAVLEELR
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLD_SHIFL
Sequence: MNKILLQCDNLCKRYQEGSVQTDVLLNVSFSVGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFNGQPMSKLSSAAKAELRNQKLGFIYQFHHLLPDFTALENVAMPLLIGKKKPAEINSCALEMLKAVGLEHRANHRPSELSGGERQRVAIARALVNNPRLVLADEPTGNLDARNADSIFQLLGELNRLQGTAFLVVTHDLQLAKRMSRQLEMRDGRLTAELSLMGAE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GCST_STAAS
Sequence: MSSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEVTGKDASQFVQYLLSNDTDNLTTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANTEKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLINQLVDEDVTEMKMFEFKQGVKLFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLHGQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGYEVMDLDGNIIGEVTSGTQSPSSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQIDK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MDH_GLAP5
Sequence: MKVAVLGAAGGIGQALALLLKLQLPAGTNLALYDIAPVTPGVAVDVSHIPTAVKVVGYAGEDPTPALEGANLVLISAGVARKPGMDRSDLFNINAGIVRNLIEKVATVCPTACVGIITNPVNTTVAIAAEVLKKAGVYDKRKLFGVTSLDVLRSETFVAELKGKDVNDVKVPVIGGHSGVTILPLLSQAFEEDKIDFTAEEVAALTKRIQNAGTEVVEAKAGGGSATLSMAQAAARFARSVLKGLTGEQVVEYAYVEGNGEYARFFAQPVRLGLNGVEELLPIGTLSAYEEEAVQAMIPTLKADIELGEKFVNG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: RBFA_UREU1
Sequence: MANEVRVARLESLIKDVINNALANEINDKIAKLARVTAVRLSNDLSVAKIFLDAHKRESMPKVLENVNKVSGLLRSKLAAEWTSYKVPELRFVIDETIDYANHIDELFKKIKQQEN
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_PROMH
Sequence: MNTLLVNQLQKKLGYTFKQNELLLQALTHRSASSKHNERLEFLGDSILSYVIANALYHRFPRVDEGDMSRMRATLVRGNTLAELAREFELGECLRLGPGELKSGGFRRESILADTVEALIGAIFLDSDIQNIENIILKWYENRLAEISPGDKQKDPKTRLQEYLQGRHLPLPSYVVVQVRGEAHDQEFTIHCQISGIDQPVKGMGTSRRKAEQAAAEQALIQLELE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLAP_ECO57
Sequence: MSHNVTPNTSRVELRKTLTLVPVVMMGLAYMQPMTLFDTFGIVSGLTDGHVPTAYAFALIAILFTALSYGKLVRRYPSAGSAYTYAQKSISPTVGFMVGWSSLLDYLFAPMINILLAKIYFEALVPSIPSWMFVVALVAFMTAFNLRSLKSVANFNTVIVVLQVVLIAVILGMVVYGVFEGEGAGTLASTRPFWSGDAHVIPMITGATILCFSFTGFDGISNLSEETKDAERVIPRAIFLTALIGGMIFIFATYFLQLYFPDISRFKDPDASQPEIMLYVAGKAFQVGALIFSTITVLASGMAAHAGVARLMYVMGRDGVFPKSFFGYVHPKWRTPAMNIILVGAIALLAINFDLVMATALINFGALVAFTFVNLSVISQFWIREKRNKTLKDHFQYLFLPMCGALTVGALWVNLEESSMVLGLIWAAIGLIYLACVTKSFRNPVPQYEDVA
What is the function of this protein?
Putrescine importer.
What are the official names of this protein?
Low-affinity putrescine importer PlaP.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EFTU_MYCCT
Sequence: MAKEQFDRSLPHVNIGTIGHVDHGKTTLTAAITKVLSEQGNAEFKDYANIDNAPEERERGITINTAHVEYKTANRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLSRQVGVPKIVVFLNKCDMVEDDEMIDLVEMEIRDLLTEYDFDGEGAPVIRGSALGALNGDSKWTGAINELMAAVDEYIPTPQRDADKTFLMPVEDVFTITGRGTVATGRVERGTVKVNEEVEIIGLKEEPTKTVVTGLEMFRKLLDFAVAGDNVGALLRGVDRHSVERGQVLAKPGTIKPHTVLKASVYALTQEEGGRHKPFFNKYRPQFYFRTTDVTGEVTLPEGTDMVMPGDNVEMEIQLIKPVAVEEGTKFSIREGGRTIGAGTVISIEK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXD4_ATEGE
Sequence: MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGTDYYGGGAQGADFQPPGLYPRPDFGEQPFGGGGPGTRSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPAPLPGARACSQSDPKQPPPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSSSCSSSTAPSQHLQPMAKDHHTDLTTL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-D4.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HTPX_RALSO
Sequence: MFNWIKTFMLMAAITALFIVIGGMIGGRSGMMLALLFALGMNFFSYWFSDKMVLRMYNAQEVSETTAPQFYRMVQELAGRAGLPMPRVYLIDEAQPNAFATGRNPEHAAVAATTGILNILSERELRGVMAHELAHVQHRDILISTLSATMAGAISALANFAVFFGGRDEEGRPVNPIAGIAVAILAPLAASLIQMAISRAREFEADRGGAVISGDPQALASALDKIHRFAAGIPFAAAEAHPATAQMMIMNPLHGGGLANLFSTHPATEERIARLMHMAQTGTYPA
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NQO1_CAVPO
Sequence: MAALRRALIILAHSEKTSFNYAMKEAAVEALQRKGWEVAVSDLYAMKFDPIISRKDITGALKDPENFQYPAESALAYKESRLSPDIVTEQKKVEEADLLIFQFPLQWFGVPAILKGWFERVFTGGFAYTYAAMYDKGPFQNKKAVLSITTGGSESMYSLKGIHGDMNIILWPIQSGTLHFCGFQVLEPQLTYGIGHTPPDVRTEILAGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLLKKEIEDEQKNNKYGLSVGHHLGKPIPTDNQIKARK
What is the function of this protein?
Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors.  In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity).  Regulates cellular redox state primarily through quinone detoxification.  Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms.  In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity).  Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity).  Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions.  Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity).
What are the official names of this protein?
NAD(P)H dehydrogenase [quinone] 1, Azoreductase, DT-diaphorase, DTD, Menadione reductase, NAD(P)H:quinone oxidoreductase 1, Phylloquinone reductase, Quinone reductase 1, QR1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: UBA3_ARATH
Sequence: MADLDVPPQVPQSKTRDLDKLLLRHGNLVDPGFVPGPGLRDDIRDYVRILVIGAGGLGCELLKDLALSGFRNLEVIDMDRIEVTNLNRQFLFRIEDVGKPKAEVAAKRVMERVSGVEIVPHFSRIEDKEIEFYNDFNIIALGLDSIEARKYINGVACGFLEYNEDDTPKRETIKPMVDGGTEGFKGHARVILPGVTPCFECTIYLFPPQVKFPLCTLAETPRNAAHCIEYAHLIQWETVHRGKTFDPDEPEHMKWVYDEAIRRAELFGIPGVTYSLTQGVVKNIIPAIASTNAIISAACALETLKIVSACSKTLVNYLTYNGGEGLYTEVTKFERDTECLVCGPGILIELDTSVTLSKFIEMLEDHPKLLLSKASVKQGENTLYMQAPPVLEEFHRPKLSKPLYDLMGRVQKDTIHVFGQRALKNNEKESCTTKVRVVFKGADGVADMDTAIGA
What is the function of this protein?
Catalytic subunit of the dimeric ECR1-AXR1 E1 enzyme.  E1 activates NEDD8/RUB1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-ECR1 thioester and free AMP.  E1 finally transfers NEDD8 to the catalytic cysteine of RCE1 (By similarity).
What are the official names of this protein?
NEDD8-activating enzyme E1 catalytic subunit, RUB-activating enzyme, Ubiquitin-activating enzyme E1-like protein.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AAEB_SALHS
Sequence: MGIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIAALIIIISMIRAPLLMILVCCVWAGFCTWISSLVRIENSYAWGLSGYTALIIVITIQMEPLLTPQFALERCSEIVIGIGCAILADLLFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKALNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGERETPVTLYSWVGAATRYLLLKRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGNGAMVMIAVVTSLAMRLPNPRMVCIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVISAGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKRLTGMLHKYQNALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYB_AVAOC
Sequence: MTNIRKIHPLMKIMNNSFIDLPTPSNISSWWNFGSLLGACLALQIVTGLFLAMHYTADTTTAFSSVTHICRDVNYGWIIRYLHANGASMFFLCLFIHVGRGLYYGSFTLSETWNIGITLLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSNLVEWIWGGFSVDKATLTRFFAFHFILPFIITALAAIHLLFLHETGSNNPLGISSNPDKIPFHPYYVTKDLLGAVLLTLLLMTLVLFFPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALISSILILAIIPLLQTTKRQSMMFRPLSQCLFWILVADLCTLTWIVGQPVENPFISIGQTASILYFSLILIIMPTVSLVENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: COPB2_ECOLX
Sequence: MSQTENAVTSSSGAKRAYRKGNPLSDAEKQRLSVARKRASFKEVKVFLEPKYKAMLMQMCHEDGLTQAEVLTALIKSEAQKRCM
What is the function of this protein?
This protein is involved in the determination of copy number in gene replication.  It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein RepA.
What are the official names of this protein?
Replication regulatory protein repA2, Protein CopB.
Protein: TRMD_GEOUR
Sequence: MKFDILTLFPAMFDGPLTESILKRAAEKGLIEVKLHNIRDFAFDRHSVTDDYPYGGGAGMVMKVEPLAACIEHAKVGSPRARVILTTPRGRSFNHAVAEELAREEALIIICGRYEGVDERVRELFVDDEISIGDFVLTGGEMAAMVLVDAVSRFVPGVLGSDESAVNDSFADGLLEYPQYTRPAEFRGLGVPSVLLSGNHQEIAKWRRRQSLGRTAASRPDLLTDAHLSASDREYLEELQRVAGSDG
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNC_SALEP
Sequence: MFDAAPIKKVSVVIPVYNEQESLPELIRRTTAACESLGKAWEILLIDDGSSDSSAELMVKASQEADSHIISILLNRNYGQHAAIMAGFSHVSGDLIITLDADLQNPPEEIPRLVAKADEGFDVVGTVRQNRQDSLFRKSASKIINLLIQRTTGKAMGDYGCMLRAYRRPIIDTMLRCHERSTFIPILANIFARRATEIPVHHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSLLGSVIAIGGFSLSVLLIVLRLALGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYNDVRARPRYFVQQVIYPESTPFTEESHQ
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HTPX_WIGBR
Sequence: MMRILLFILTNLSVMIIFGIILFITGIKSSSSFGLIIMSGVFGFGGSIISLLLSKYIAINSVNAKIIKNPKNDIENWLFNTIKLQSQKANIGTPDIAIYDAEDINAFATGPKKNSALIAVSTGLLNNMSKKEAEAVLAHEISHISNGDMITMTLIQGVVNTFVIFLSRVISKFIVNLFSTNKEDENSYESENSWSYFFISMALEVVFGILASIITFWFSRKREFYADAGSAEIVGKNNMIAALQKIKNTCEPNVGKELLAFCINGKKSFNEIFMSHPPIDKRIQALIQEKYMKK
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IF1_STRT2
Sequence: MAKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDRVTVEMSPYDLTRGRITYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEGJ_ECOLI
Sequence: MKKILLMLSLLFFTTAGFSEVSDTLVTGGYDKQAMSDAIKHARKETDKFIEVMNKKDADTFAVKAPITDHGRTEHFWLTDVTYSNGMFIGVISNDPGIVTNVEYGQEWKIKKEDISDWMYTRGDKIYGGYTIDPLLVTYPKEEADELRAKLVR
What are the official names of this protein?
Uncharacterized protein YegJ.
Protein: TRMN6_MUSP7
Sequence: MSARQHTPDLRADGFTFKRFFIAHDRCAMKVGTDGILLGAWAPLRHESRILDVGCGSALISLMLAQRCEGRVPVDAVELDIAASVQAAENVAASPWRDTVVVHQADIVEFSCTTPHRYSLVVSNPPYFAAGVACASPQRTQARYTSSLSHEALLHSVSAVLMPEGRFCVVLPSQIVGDFLFLAESLQWHLALRVDVADNPRRPVHRVLLALTQAPIDPVYSSALLIRDELQQYSPDYRALTQDFYLSM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2HB_TRIPE
Sequence: MRTLWIMAVLLVGVEGSVIQLGKMILQETGKNPVKYYGAYGCNCGPLGRRKPLDATDRCCYMHKCCYKKLTDSNPIKDSYSYSWENKAIVCKEKNPRLKEMCECDKAVAICFRENMDTYNKKERINTKIFCKKTPEPC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks catalytic activity (PubMed:15955061).  Induces mild local edema (PubMed:15955061).  Is myotoxic (By similarity).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog Tpu-K49b, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TIM21_HUMAN
Sequence: MICTFLRAVQYTEKLHRSSAKRLLLPYIVLNKACLKTEPSLRCGLQYQKKTLRPRCILGVTQKTIWTQGPSPRKAKEDGSKQVSVHRSQRGGTAVPTSQKVKEAGRDFTYLIVVLFGISITGGLFYTIFKELFSSSSPSKIYGRALEKCRSHPEVIGVFGESVKGYGEVTRRGRRQHVRFTEYVKDGLKHTCVKFYIEGSEPGKQGTVYAQVKENPGSGEYDFRYIFVEIESYPRRTIIIEDNRSQDD
What is the function of this protein?
Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.  Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex.  Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim21, TIM21-like protein, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the TIM21 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: RL2_PSECP
Sequence: MGIRKYKPTTPGRRGSSVADFTEITRSTPEKSLVRPLPKKGGRNNTGKITTRHKGGGHKRQYRLIDFRRHDKDGVDARVAEIEYDPNRTARIALLHYVDGTKRYIIAPNKLSQGDFVEAGPNADIKPGNNLPLRNIPVGTVVHAVELRPGGGAKMGRSAGASIQLVAREGRFAQLRLPSGEIRNVDVRCRATVGEVGNAEQSNINWGKAGRMRWKGVRPTVRGVAMNPVDHPHGGGEGKTSGGRNPVNPNGQREGRTRRPNKESDKLIVRRRRTGKNKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.