PharMolix/UniProtQA huggingface dataset:
Protein: TRPB_BACTN
Sequence: MKSFLVDQDGYYGEFGGAYVPEILHKCVEELKNTYLGVLESEDFKKEFDQLLRDYVGRPSPLYLARRLSEKYGCKMYLKREDLNHTGAHKINNTIGQILLARRMGKKRIIAETGAGQHGVATATVCALMDMECIVYMGKTDVERQHINVEKMKMLGATVIPVTSGNMTLKDATNEAIRDWCCHPADTYYIIGSTVGPHPYPDMVARLQSVISEEIKKQLMEKEGRDHPDYLIACVGGGSNAAGTIYHYINDGRVGIILAEAGGKGIETGMTAATIQLGKMGIIHGARTYVIQNEDGQIEEPYSISAGLDYPGIGPIHANLAAQRRATVLAVNDDEAIEAAYELTKLEGIIPALESAHALGALKKLKFKPEDVVVLTVSGRGDKDIETYLSFNEK
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RL11_SHEPW
Sequence: MAKKVDGYIKLQVAAGAANPSPPVGPALGQKGVNIMEFCKAFNARTEKFDKGMPIPVVITVYTDRSFTFETKTPPASFLLLKAAGLKSGSGRPNTDKVGTIKRSAVQEIAETKAADMTGADMDAMMRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: MSH3_ASPTN
Sequence: MPLSSSQSSPPSSQNLKRKQQTISSFFTKKPQSTKPEESHGADEKQRTNGAEEVGNENRAPPHTADAAEEDDDDIVAPAPKRARTNAHRQKDTDQTSDGPPRIAEPPKSSQRTELAKFASSPAGAAEPEEMDEEEAQERKKEREKLHKQFVRRLGGPDCLIGINRHVSGEADPALEEAAEADEDEEAVQAPPAKGKAAAKKGGGKLTPMERQIIDMKRKHMDKILAVQVGYKFRFFGEDARVAAKELSIVCIPGKFRFDEHPSEAHLDRFASASIPVHKLHVHVKRLITAGHKVGIVRQIETAALKAAGDNRNAPFVRKLTNVYTKGTYIDDMEGLEGPTAGAGTTAATGYMLCITETNAKGWGNDEKVHVGIVAVQPATGDIVFDDFEDGFMRSEIETRLLHLAPCELLIVGDLSKASDKLVQHLAGSKMNVFGDKVRVERTTKSKTAAAEAHSHVSSFYADKVKSANASDDTQASNLLQKVLNLPEQVSICLSSMIKHMTEYGLEHVFDLTKYFQHFSSRSHMLLNGNTLMSLEIYQNQTDHSSRGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKSKLEERVNAIEELKSMEKVAMVERLKGVLGKAKCDLEKILIRIYYGRCTRPELLTGLQTLQMIAQEFGDVKSPEDSGFTTPILNEAIASLPTILEDVLSFLNKINLHAARNDDKYEFFREAEETEDISEHKLGIASVEHELREYQSVAGKILGRSKIQYVTVAGIDYLIEVENNSSYLKRVPASWVKISGTKKLSRFHSPEVIKLLRQRDQHKEALAAACDHAYASLLAEIAANYQPFRDCVQSLATIDCLLSLSSIANQPGYVKPEYADNTCIHVEQGRHPMVEQLLLDSYVPNDINLDSEETRALLVTGPNMGGKSSYVRQIALIAIMGQVGSYVPAQSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRSLRSLTLFITHYQHLSSMVHSFPNHELRNVHMRFTESGSGQDEEITFLYEVGEGVAHRSYGLNVARLANLPVPLIEVAKQKSAELEQKIRRRRLAGLMSTVENIMSDSAKNDEGLITRLISSAEQL
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  Msh3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein msh3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MK06_PONAB
Sequence: MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECGHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVNGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN
What is the function of this protein?
Atypical MAPK protein.  Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5.  The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6.  May promote entry in the cell cycle (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase 6, MAP kinase 6, MAPK 6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
Protein: RL23_SORC5
Sequence: MQPEQIIRRPIILTEKSSRLRDQGNKVIFEVRREANKIQIKDAIQTLFKVGVVDVNTLIMRGKDKRMGRGYAKLRNWKKAIVTLKEGDEIQFFDEKAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RL3_SALTI
Sequence: MIGLVGKKVGMTRIFTEDGVSIPVTVIEVEANRVTQVKDLANDGYRAVQVTTGAKKANRVTKPEAGHFAKAGVEAGRGLWEFRLAEGEEYTVGQSISVELFADVKKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGKVFKGKKMAGQMGNERVTVQSLDVVRVDAERNLLLVKGGVPGATGCDLIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: Y364_RICPR
Sequence: MATKNKKEIVNTETKNLANLIIKEISKESFDFGILQKMQQAFSTASKQKQREAFINILDTKLDKEQLHKLNQTIMKNANELMPDNDPNFVCRTSNNKVFQEILLLEAKRSGMQARFSDTGALQSLDIKDITPEILDHYRVLQEKFYLKRNSKDSVDSRIAQSINFLLYAPLFRESDIYKKLGLKSAEIEREIQDPNGKYVQQLIDAKIGSNIPFHMQKNNVNEGKEIERTAIIEKAITKFEQDKKFSFEGKKRDEITKYLSKSLEGASDYILTFKKNELVDVIYQGLDKGQTLWSKVANYIGIKSYSISKENLKSVAKIINDKIKSSHTPLKIEVQDKLKQISKELNRLNNPVLPSEAQKVQVKSNKKPPIAPKPEHLKKRDHGLC
What are the official names of this protein?
Uncharacterized protein RP364.
Protein: NIRH_PSEAE
Sequence: MSACISPSDALLARRLIELTQAGLPLVADPWAWIAAQLRLSEAETLALLKRLRDAGVIRRIAAVPNHYRLGYRHNGMTVWDVADERIERLGRLVGGLSFVSHCYRRPRHLPQWRYNLFAMVHGRSEAEIEGYRQQIRLLLGEDCRADEMLVSSRILKKTGLRLAQKEERPC
What is the function of this protein?
Involved in heme d1 biosynthesis (PubMed:8982003).  Catalyzes the decarboxylation of siroheme into didecarboxysiroheme (By similarity).
What are the official names of this protein?
Siroheme decarboxylase NirH subunit.
What is the protein family that this protein belongs to?
Belongs to the Ahb/Nir family.
Protein: PANB_MYCSJ
Sequence: MSEQTVYGAASDQPTPKPRVKVRTTHLQKWKAEGHKWAMLTAYDFSTARAFDDAGIPVLLVGDSAANVVYGYDTTVPITIDELIPLVRGVVRGAPHALVVADLPFGSYEEGPRQALATATRFLKETGAHAVKLEGGERVAEQIATLSAAGIPVMAHIGFTPQSVNGLGGFKVQGRGDAAEQTIHDAIAVQEAGAFSVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLVWQDMAGLTSGRTAKFVKRFGDVGAELRRAASQYADEVAAGVFPAEEHSF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP5L_RAT
Sequence: MAKFIRNLADKAPSMVAAAVTYSKPRLATFWHYARVELVPPTLGEIPTAIQSMKSIIHSAQTGNFKHLTVKEAVLNGLVATEVWMWFYIGEIIGKRGIVGYDV
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane.
What are the official names of this protein?
ATP synthase subunit g, mitochondrial, ATPase subunit g, ATP synthase membrane subunit g.
What is the protein family that this protein belongs to?
Belongs to the ATPase g subunit family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: PQQA_METEA
Sequence: MKWAAPIVSEICVGMEVTSYESAEIDTFN
What is the function of this protein?
Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis.  PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide.  There seems to be another source for PQQ in this bacteria only.
What are the official names of this protein?
Coenzyme PQQ synthesis protein A, Coenzyme PQQ synthesis protein D, Pyrroloquinoline quinone biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the PqqA family.
Protein: YMW4_YEAST
Sequence: MDPELQAIREARLAQLKNNSGGTNGDRNSGANNGGGENSAPVGAAIANFLEPQALERLSRVALVRRDRAQAVETYLKKLIATNNVTHKITEAEIVSILNGIAKQQNSQNNSKIIFERKDFSEDLNSFDKQNAKNDDDEDDDDFFD
What are the official names of this protein?
Uncharacterized protein YMR074C.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: ALR_FRATW
Sequence: MNILKISKQTLRNNIKIIREYIGNAKMCFPVKANAYGHGIEDIVENTHDLVDFFAVANSLEAFRVTAVAKNPVLVFGVIYYEYIEKMISENIRVSIQDYEDIEKLEQIAKELDKKVYAHININTGMNRMGVDYNDACRTIQRAYESDWLILEGVYSHLACADNRDHPTNIKQKNRFDSIVKFTKGLSQDIICHLSNSYGFLGQKGICYDMVRPGILSYGFLPEFYVDRVIREIKPIARLLSKVVKIITLQEGEGVGYSLIYRGFEGEQLAVIPIGYGDGFPRELGDRGFVNINDVMYPMAGRMSMDSLTVSLGINEYDVKVGDTVELISAIPRNRNSAFSIAKQTNTIEYDIMSTLNDRIIRKII
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: MVHG_METFE
Sequence: EECEREKPPEGLAMDFIKRQFEIGEPEKDLCLIAQGLVCMGPATTSICGAQCPKVGIPCQGCYGPTKAVEDQGAKMISAIASDFGVEKDKTVDPEKVAEQLDDIVGTFYTYTLPASLIPMRVHKGGK
What is the function of this protein?
Part of a complex that provides reducing equivalents for heterodisulfide reductase.
What are the official names of this protein?
F420-non-reducing hydrogenase subunit G, Methyl viologen-reducing hydrogenase subunit gamma, MVH subunit G.
What is the protein family that this protein belongs to?
Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
Protein: T2R30_HUMAN
Sequence: MITFLPIIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITAYNVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEYEGNVTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFLSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFLSVLRHVRYWVKDRSLRLHRFTRGALCVF
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 30, T2R30, Taste receptor type 2 member 47, T2R47.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYGB_STRP4
Sequence: MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLKENRLSFEAIQTFSTPRRLAVRVTGLSDKQSDLTEDFKGPAKKIALDSDGNFTKAAQGFVRGKGLTVEDIEFREIKGEEYVYVTKEEVGQAVEAIVPGVVDVLKSLTFPVSMHWAGNSFEYIRPVHTLTVLLDEQEFDLDFLDIKGSRVSRGHRFLGKETKIQSALSYEEDLRKQFVIADPCEREQMIVDQIKEIEAKHGVRIEIDADLLNEVLNLVEYPTAFMGSFDAKYLEVPEEVLVTSMKEHQRYFVVRDQDGKLLPNFISVRNGNAERLKNVIKGNEKVLVARLEDGEFFWREDQKLVISDLVEKLNNVTFHEKIGSLREHMIRTGQITVLLAEKAGLSVDETVDLARAAAIYKFDLLTGMVGEFDELQGIMGEKYTLLAGETPAVAAAIREHYMPTSAEGELPESKVGAVLAIADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDAFGWHIAMDELIDSLYALKFDSLTYENKAEVMDFIKARVDKMMGSTPKDIKEAVLAGSNFVVADMLEAASALVEVSKEEDFKPSVESLSRAFNLAEKAEGVATVDSALFENDQEKALAEAVETLVLSGPASQQLKQLFALSPVIDAFFENTMVMAEDQAVRQNRLAILSQLTKKAAKFACFNQINTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H33_RAT
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes.  Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TBD_MOUSE
Sequence: MSIVTVQLGQCGNQIGFEVFDALFRDSHCSQGLCSKRDNEAYQASCRERFFREEENGVPVARAVLVDMEPKVINQTLSKAAQSGRWNYGQHTSFCQKQGSGNNWAYGYSVHGPKHEESIMNLIQTEVEKCDSLSGFFIIMSMAGGTGSGLGAFVTQKLQDQYSSSLKMNQIIWPYGTGEVIVQNYNSILTLSHLYRSSDALLIHENDAVHKICAKRMNIKQISFRDLNQVLAHQLGSVFQPTYSEDSSFHYRRNPLGDLMEHLVPHPEFKMLGVRNIPQMSAASLAYSAFTWAGLLKHLRQMLISSAKMEEGINWQVRPPLTGLPPIGKASAHKEHHFNTSLANLVVLRGREVHSADVEGFKDPALYTSWLEPVDAFSVWKTQRAFDKYEKSAALVSNSQLLVKPLDMIVGKAWNMFSSKAFIHQYTKFGMEEEDFLDSFALLEQVVASYGSLGP
What is the function of this protein?
Acts as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584).
What are the official names of this protein?
Tubulin delta chain, Delta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Nucleus. Note=Associated with centrioles (PubMed:10753753). Both cytoplasmic and nuclear (PubMed:10753753). In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head (PubMed:10753753).
Protein: NEP_I02A6
Sequence: MDSNTVSSFQDILMRMSKMQLASSSEDLNGMITQFESLKLYRDSLGEAVMRMGDFHSLQIRNGKWREQLSQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLLEVEQEIRAFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RS7_RENSM
Sequence: MPRKGPAPKRPLVLDPVYGSPLVTQLINKILVDGKKSTAERIVYGALEGAREKSGGDPVAALKKAMENIKPSLEVKSRRVGGATYQVPVEVKPGRATALALRWLVGYSKARREKTMTERLRNEILDACNGLGAAVKRREDTHKMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: BIOW_META3
Sequence: MAFSIKMRASKGDKHISGAETIVMEKENIENITAGYIKRALEHELGAPDFINIKIDKINKKDIIYIDALPIKTINCKNKEDARRVAKNLLKNEGISDKLIEKSFKIIDDGGMRGAPILNLNGERLEPDKERGVRVKNISTTEELKEKILKNNIGTDRTVDAIAIASKVINLGVIAELCTSDNNSYTTGYVATKNGYFRITNLKQENENGGRVFFVKNDTNIEDLIYKLENKPYIIK
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: GCST_FRAT1
Sequence: MLKTPLYESHMAANAKMVDFSGWSMPINYGSQIQEHNNVREDCGIFDVSHMLAVDIQGSEAEKFLRYLLANDVAKLQENKAQYGCMLNHDAGIVDDLITYKVTDEHFRIVVNAGNRESDVAWFNQNAQNFDVAITPQTDLAIVAVQGPKAVAVIKRVVTKEIATEIEALLPFSFKFFSKWMVARTGYTGEDGFEVILPATQVKKFWDSLLENGAQPAGLGARDTLRLEAGMHLYGADMDTSTTPLERGLGWSVDLSDEHRDFIGKKAYFAKKAQGVDTKWVGVVLKTKGVLRAGQEIDFDNGEKGYITSGSFSPTLKVAIGLAYVPKQADNPVVNIRGKELEVELVKPKFVKNGKSLI
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: RLMF_SHELP
Sequence: MTPSRKPARPGAKKVVSQEPSAKASRPKPSSQSKSKAQPKAKPESKPQAKSQAKPQAKSKPVEGKSQGASKGLHPRNLHGQGYDFDALMDTTPELKPFVRPNPYGNLSIDFADPRAVKLLNLALLRLHYGLSYWDIPEGFLCPPIPGRVDYLHYLADLLAESTPASKGGKRKLPNVTRAPKGERVVALDIGTGANGIYPLLGHQVYGWRFVASDIDPVSLKNVERIIANNPQLAGKLSLRLQSDSKQIFTGIIRAEDRFDLTLCNPPFHASLAEASRGSERKLKNLAANKRAKGHEVAKSKEKLNFGGQKAELWCEGGEQAFLGQMIRESQKFGSQCLWFTSLVSKKENLKPCYRLLEQVGAKRVETLEMAQGNKLTRVLAWTFLTPEQHSLWGLYRV
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPF_LACGA
Sequence: MAFDKLGRFFGIAEDDEMNEAPYTEAEQQEEEVPQAQKNERRANVVSINSGVGATSKIVLYEPRVYSDAKEVAQNLLNNKAVIINFARMDDEQARRIVDFITGTVYALNGEIQRVGDKIFLATPPKFETDGKIAELVEKKDKMD
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RS18_EDWI9
Sequence: MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: EFE_PSECA
Sequence: MTNLQTFELPTEVTGCAADISLGRALIQAWQKDGIFQIKTDSEQDRKTQEAMAASKQFCKEPLTFKSSCVSDLTYSGYVASGEEVTAGKPDFPEIFTVCKDLSVGDQRVKAGWPCHGPVPWPNNTYQKSMKTFMEELGLAGERLLKLTALGFELPINTFTDLTRDGWHHMRVLRFPPQTSTLSRGIGAHTDYGLLVIAAQDDVGGLYIRPPVEGEKRNRNWLPGESSAGMFEHDEPWTFVTPTPGVWTVFPGDILQFMTGGQLLSTPHKVKLNTRERFACAYFHEPNFEASAYPLFEPSANERIHYGEHFTNMFMRCYPDRITTQSINKENRLAHLEDLKKYSDTRATGS
What is the function of this protein?
Simultaneously catalyzes two reactions, namely formation of ethylene and of succinate from 2-oxoglutarate.
What are the official names of this protein?
2-oxoglutarate-dependent ethylene/succinate-forming enzyme, EFE, Ethylene-forming enzyme, 2-oxoglutarate dioxygenase (ethylene-forming), 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming).
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: PRIO_CERMO
Sequence: MLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHNQWHKPSKPKTSMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYEKESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.