PharMolix/UniProtQA huggingface dataset:
Protein: EMC2_XENTR
Sequence: MSKVSDLYDVTWEDMRDKMKTWREENYRNSEHVIEVGEELINEHASKLGDDIWIIYEQVMIAALDCGRDDIAMSCLQELRRQFPGSHRVKRLTGLRFEAMERYDDALQIYDRILQDDPTNTAARKRKIAIRKAQGRNAEAIRELNEYLEQFVGDQEAWHELAELYINELDYAKAAFCLEELILTNPHNHFYYQQFAEVKYTQGGLENLELSRKYFSQALKLNNHNMRALFGLYISSVHIASNPKASAKMKKDNVKYATWATSQIKKAYQLAGRTMTDTQTSLKAVEDMLETLQITQS
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
What are the official names of this protein?
ER membrane protein complex subunit 2, Tetratricopeptide repeat protein 35, TPR repeat protein 35.
What is the protein family that this protein belongs to?
Belongs to the EMC2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS10_METM6
Sequence: MQKARIKLSSTQHVELDGVCDQIKAIAEKTGVDMAGPIPLPTKALKVTTRKSTDGEGSSSFDRWTMRVHKRVIDIEADERTMKHIMKVRIPDTVQIEIELRN
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: MURC_STRPG
Sequence: MSKTYHFIGIKGSGMSALALMLHQMGHMVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAYALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTNGSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTEIVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVKVEDLAAKIIKPSQVVTVENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_SALAI
Sequence: MELLHSGKVRDVYADGGDLILVASDRISVYDVVLPTPIPDKGKLLTALSLWWFDQLAELVPNHVLSATDVPPEFAGRAIRCRRLDMVPVECVARGYLTGGGFAEYQRTGAVSGVELPRGLVEAAALPEPVFTPSTKAPVGEHDQPITFGGVVDRVGAETAERLRRITLDVYRRGAELAAGRGILIADTKIELGWAADGTLTVGDELLTSDSSRFWPVESYQPGRAQFSYDKQYVRDWATRSGWDKQSPAPELPGEVVDATRARYVDVYEKLTGKRWG
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: QUEE_PROMA
Sequence: MSTCLPIVERFHSLQGEGLHFGKSAFFIRLGGCKVGCPWCDTKESWSIATHQEATVEELSKEAAIAQSQGAAILVITGGEPLHHNLNALCKTIQDFTSHNSRETMPIHLETSGVDEITGLINWITLSPKRHALPKKSLLRACDEIKVVIHQKEDLLFAEEMANQSIKERQISKKTSDENHKISQPHLFLQPGWNSKEGTQLTIEYIKSHPQWRLSLQTHKWLGVL
What is the function of this protein?
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
What are the official names of this protein?
7-carboxy-7-deazaguanine synthase, CDG synthase, Queuosine biosynthesis protein QueE.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
Protein: RS14Z_MALP2
Sequence: MAKKSLIVKQKKHPKFKVRAYTRCERCGRPRAVIRKFGICRLCFRDLAYKGAIPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: NUOD_MYCUA
Sequence: MTDTETVLVAGGQDWNEIVEAARGADPGERIVVNMGPQHPSTHGVLRLILEIEGETVTEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDEIPERVNVIRVMMMELNRISSHLVALAAGGMELGAMTPMFVGFRAREIILSLFESITGLRMNSAYIRPGGVAQDLPPDRPTEIAKAIADLRQPLREMGDLLNENAIWKARTQDVGYLDLAGCMALGITGPILRSTGLPHDLRKSEPYCGYENYEFDVITADGCDAYGRYMIRVKEMWESIKIVEQCLDRLRPGPTMIEDRKLAWPADLKVGPDGMGNSPEHIAKIMGSSMEALIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQAVAAMSEGGMVADLITAVASIDPVMGGVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATPF_ANTAG
Sequence: MRNLIFFVIPFHFWLPAEGFKLNTNLLETNLINLGVVLGLLVYFGKGVLNNLLDKRKQTILSTIRDAEERYKEATDKLKQAQIRLQQAELKANEIRVNGLSEMEKEKQDLINIADEDSKRLEDSKNATIRFEEQRAIEQVRQQVSRLALERASEVLNNCLNSELHSRMIDYHIGLLKTMGSTTE
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: QUEA_BACAC
Sequence: MDINLFDFHLPEELIAQVPLEERETSRLMVLDRETGDIEHKHFTDILSYLHEGDCLVLNETKVMPARLHGVKEDTGAHIEVLLLKQEEGDKWETLVKPAKRVKEGTVISFGEGKLKATCTGTADQGGRQLEFSYDGIFYEILDELGEMPLPPYIKETLEDRDRYQTVYAKEIGSAAAPTAGLHFTEELLEKLKQKGVELAFITLHVGLGTFRPVSADTIEEHHMHAEYYHMSEETAALLNRVKENGGRIITVGTTSTRTLETIATDHDGKLCAASGWTDIFMYPGYEFKAIDGLITNFHLPKSTLIMLVSAFANRDNVLHAYNEAVKEKYRFFSFGDAMFVASHAKMGNK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_SHIFL
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: YEJL_ECO55
Sequence: MPQISRYSDEQVEQLLAELLNVLEKHKAPTDLSLMVLGNMVTNLINTSIAPAQRQAIANSFARALQSSINEDKAH
What are the official names of this protein?
UPF0352 protein YejL.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: RL18_METBF
Sequence: MATGPRYKVPFRRRREGRTNYHLRLKLLISKQDRVVVRKSARNVQIQLIAPTPEGDITYSSAVSSELAKYGYTGVTGNTTAAYLTGLLFGLKSLKKGYEGGILDIGLQASSAGSRVYAALKGIVDSGFEVPCSPEVFPSDERIRGEHIAEYREESSDLPEQFEATKEKIFAEFS
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: Y195_MYCPN
Sequence: MDSFFINGYVPRDTFIHRLHPTTKLLIFLLFVILVFVPIGFVFQSVIFVFATVIFFVAKLPGRFYLSSIKSISLLFLLLLFVNWFTFRDPGFYITADQVNTVKPHFNGNNFNFWNISLFNYQDNVFSQVFNFNRANMTELNKINFFFKETANANAYTKVTGIDKLAEMLASKNLFKFNGSTNGIDKNKILGAFLDHKIAVYLGRSWGGDFSGFVIDVSVSDKTSTFTIKPFLANSNYVLTLRAIILAFYVTQKILIMIILATVLTSTSSSVELAYGIERLLWPLKLLRVPVNVFAMTIAIAIRFVPSLLLESQRILNAQASRGLDFKNGNFFVKMRSLSSLVVPMISIAFRNAGELASAMEARGYDPTKKRTTYRKFKIDWVDATALILTALYFVVIIFLTVKGAVFLDLGTPEWLLTGKIKEQVERSLSVKSA
What are the official names of this protein?
Uncharacterized protein MG181 homolog.
What is the protein family that this protein belongs to?
Belongs to the CbiQ family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UL38_HHV6Z
Sequence: MAFTGDELARMLQFKDKMISSAGSALRFEKVVQEAMASGIVLQHITCIKVRICDNSDILSDRQLRCLLINGLYPFEGRMSMFGVTEEWEGASAAPERQVVFLLSSTGQVLGYEDGVIFYLSPTFSDFWTTAMEFSCQNAILSNFIAQKSRDEYSDQFQKYFTRMRHTPISLTGVLPRRFQKVESGACVEEDARASMRPIQSDSFGAKGPFCWPTEELLQPSAKKDVGGTVCMALSCQEDNSARHCTIYGLTKTPGIKIMLSRHTQTDRSEAMCDAATQTEDVVDNSSETLFLGGNLVHQSILETEVQATAKNTFDVSDPRIDSVYDTTVVGAMATDDVGCKHVQGGASLAQEKPLKGYCIIATPSECKPNIHWLKSPENAVHESAAVLR
What is the function of this protein?
Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication.  Promotes stabilization and inactivation of host TP53 through interaction with host MDM2.
What are the official names of this protein?
Apoptosis inhibitor U19.
What is the protein family that this protein belongs to?
Belongs to the beta-herpesvirinae UL38 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=localized in the host nucleus at early times postinfection and then increases in both nuclear and cytoplasmic compartments during the course of infection.
Protein: RS9_PELPB
Sequence: MKEVIDTVGRRKTSVARAFMIPGKGRVIVNKLPIEEYFKDEFKRQQALRPLVITERAEEFDIKINVQGGGVSGQSGAVSLAIARALTEFDETARVILKTEKLLTRDPRMVERKKFGRKKARKRFQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: IDI_SHISS
Sequence: MQTEHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPNGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQAANSEARKLLSAFAQHN
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFB4_DEBHA
Sequence: MDAIADSVFTDIGSSDSPSDDPSLLTVVLDVTPQSWYKIRNQITIQEVAKSLLVFLNAHLSLNNSNQVAFIASTPQGSKFLYPNPEKNYDEVSSKKNGEGSNLNKADSTSSLVGDGMYRQFRIVDEAVLEKLNEIFADISQNVDKSRSNSTLSGALSLALTYTNRMLNLDSSISTTTASAINTTTNANSNKTSSSGTTSNSMSTGGTNTTSLTSMRSRILIVSSNDDNDIKYIPIMNTTFAAQKMKVPIDVAKLGERDSSYLQQASDATNGVYLHIANPEGLIQTLSTAFFIEPSIRSLIILPTNSNVNYRASCFITGKSVNLGFVCSVCLCIMSIIPKEGKCPTCGSKFDEKILAQLRRGVVIPVKKKRKLDSNGNGQSDNVTPEI
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH subunit TFB4, TFIIH subunit TFB4, RNA polymerase II transcription factor B subunit 4.
What is the protein family that this protein belongs to?
Belongs to the TFB4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS18_ENDTX
Sequence: MTFIRKPAGQAKPQKYSTDAYGRPAGKFRRNGPIRKKVCRFCADKVEIDYKNLSLLHTFVTEKGKILSGRMTGTCAKHQRELDTAIKRARMIALLPFTVN
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: GET3_RHOGU
Sequence: MASTAFVCAEPEGDALPPSLQNLLDQDSLKWIFVGGKGGVGKTTTSCSLAIQLAAVRESVLLISTDPAHNLSDAFSQKFGKEASKVNGFTNLFAMEIDPSASMQDMVESGDDSGMNGMMQDLAFAIPGIDEAMGFAEVMKHVKSMQFSAIVFDTAPTGHTLRFLSFPSVLEKALGKLSGLSGRFGPMLNQIGSMMGGGLNTSEMFEKLESMREVVTEVNAQFKNPDLTTFVPVMISEFLSLYETERLIQELTQYQIDVHDIVVNQLLYPENDSQCKHCKVRWTQQQKYLKEAYELYGEDFHIVRMPLLSQEVRGTDALKKCLLIEPYKAGQVVDLSASS
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: MURA1_STRP6
Sequence: MDKIIIEGGQTRLEGEVVIEGAKNAVLPLLAASILPSKGKTILRNVPILSDVFTMNNVVRGLDIRVDFNEAANEITVDASGHILDEAPYEYVSQMRASIVVLGPILARNGHAKVSMPGGCTIGSRPINLHLKGLEAMGATITQKGGDITAQADRLQGAMIYMDFPSVGATQNLMMAATLADGVTTIENAAREPEIVDLAQFLNKMGARIRGAGTETLTITGVTHLRGVEHDVVQDRIEAGTFMVAAAMTSGNVLIRDAVWEHNRPLISKLMEMGVSVTEEEYGIRVQANTPKLKPVTVKTLPHPGFPTDMQAQFTALMAVVNGESTMVETVFENRFQHLEEMRRMGLQSEILRETAMIHGGRQLQGAPVMSTDLRASAALILTGIVAQGVTIVNNLVHLDRGYYQFHEKLAKLGATISRSSEV
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, Enoylpyruvate transferase 1, UDP-N-acetylglucosamine enolpyruvyl transferase 1, EPT 1.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCD_GRAFK
Sequence: MAWFKRTQKGIQTPTEHKKDVPKGLWYKSPTGKIVDAEQLESNFYVSPEDGYHVRIGSNEYFKILFDDNKYKELDKGMTSKDPLDFEDTKKYTDRLKAAQEKTGLKDAVRCAVGKSKGNDLVIACMDFKFVGGSMGSVVGEKIARAADYALKNKLPFMIISKSGGARMQEAALSLMQLAKTSVKLAQLADAKIPYISLATDPTTGGTTASFAMLGDINISEPGALIGFAGPRVVKDTTGKDLPKDFQTSEFLKEKGFLDFITKRSELKNKINLYLDLIQNQPVRA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PR4A1_RAT
Sequence: MHLSLSHQWSSWTVLLLLVSNLLLWENTASAMRAKLLNVHNYTSYGDTWNQAIKISQDMNQYISDLSTHVKIFYAQGRGFERRTTRCHTSSLSSPENKEQAQQFQLEVLLGLSHSLLQAWLNPLHHLWAEMCDRLGSTPPTLYKALMLKESNIKLLDAIKNIAKKGNFEINEKANYTAWSELGFLQSPNRDTRYFAFYNLFHCLKKDSNNVEMYLKLLKCRLIRSKC
What are the official names of this protein?
Prolactin-4A1, Placental prolactin-like protein A, PLP-A, PRL-like protein A.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZC3HF_CHICK
Sequence: MPPKKQQQPAGSSKKADQKKKEKIIEDKTFGLKNKKGAKQQKFFKAVTHLVKFGQQYPRQAAQTESEKKLKKEDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLSLERKCEKRSVYIDARDEDLEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCKYFLDAIENNKYGWFWVCPGGGDNCMYRHALPPGFVLKKDKKKEEKQDEISLEDLIEKERAALGPNVTKITLECFIAWKRRKRQEKIDKAEQDMERRKADFKAGKALVISGREVFEFRPELVDADDEEADDTRYTQGTGEDDEVEDPVCVNDVDLSLYVPKAVDETGITVASPERFSTYASIEKDDNKLSEASGGEINSSEQNDLEDRDGDEELENGVMDAVPVDENLFTGEDLDELEEELNTLDLEE
What is the function of this protein?
Protects DRG1 from proteolytic degradation.
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 15, DRG family-regulatory protein 1.
What is the protein family that this protein belongs to?
Belongs to the ZC3H15/TMA46 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y6969_DICDI
Sequence: MYSGLWTKNGEQILPSFISINAKVVDLAAQIVFTKTYSDINKYFATMNKMNSSNEEDATFKAFLNTSMGVLCGFEINLDGKKITSQVVSQADAMRLFEKNQISTADDIVKEAEFNNSDPHIEEDFFLCKVNNLSQYKELEIIITYSTEMSTQGDYLFMEFPTSLTTIRSSQFFETLDNENSTTNTNTQTQPQSVNTTTTTTPSTTTATNITNINNNIQNIGSSTTGGLTHSTSSNKLSLSSSSIQVNQKQGLLIEMNLDMPSKISEIISPSHSGLIDVEYKGETGKVTYKDSRSIDVVNQSDLVVLIKLDNPHEPYGFIEENENGSRALMIAFYPQLSSAAIAASATTPVVESELIFLVDVSESMEGYNMKHAKKALHRFLHSLSKDTYFNIISFASSHRKLFAQSVKYNDENLKAATAYVESLKAISHGETNLLEPLKDIYSVDATCPRKIFLLTDGRVNNIGPIVDLVRQNAHNTSVFPIGMGEFVSRQLVEYIANAGSGVAELVIENETIESKVMRQLKRALQPAMSNIKVDWGSLSSKSQAPRDLRTLFFGDRLTIYNILGKDEKIDGTTVKLIANGPTGPVSFPVTIKSEETKKGNLVHSLAAYTLIQDLQDQIYENNLVDPKDIDPIRQKIIDLGIKYGLASNYTSFCSVEQPDQFNELLNNNKQSEQAQETTTTTTTATTVDDNVVIEENKQPEPIVEEQPPVLNGNINLQNLTINHDGKSNDNGLFKSNDRLKTHHQGESAMISLRGSASGIPTTLSGSGIPFYNPSSPNHDRNINTTQQPTPTQSTPLKTPLKTPLTPLSKSGLKVSSPEFVPKNTLSAKAAPFVPSPNKLPTTTTSAPATTPITTPAPTTTTTEVKPTVAEPVKPVVAEPTKPVVAEPTIPAVAEPIKPVVTEPTKPVVEEPAKPAVKPTLFEMIKIAEAKAAAEQKAAAEQKAIADAKAAAEQAAKPVEPAVVQQQQPQQTKPKADKQSKQNAKDNKQSNKPVVVEQKPPVVTETKPTVATESATPTKPTFAQAAAAAAAAAQQAAQQAAATTPVKQQPTKQTTPNKSTPAVETKSVVAETKPAVEQPKPVETKPVVEQPKPVETKPVEQTKPVETKPVEVKPTVEQPKPVEVKPTVEQPKPIETKPTVNSIASTLANFGFQTNEPAKQATPTPAPTPVQSNESNNNNNNNNNNNNNNNNNNNNNNNIVSSTPIKKPAVTNILPTQAVILSSGGRRVYNNDFLLSFKDSNTKAPDSLKTTPIFSNGPQGISPSSGNGSNKSHFGKKRGDRGGRGGRDRNADAEPSTPIIVKKVFSQDVQGTHQELLKKFKFNLNRITMDTYSSLIKNIDELKVPDEEALKSISKILFEKAIIDQKYSAVYAILAGHLDTTFPKFAELSLKRAILDNCQTEFSAVVDKSKFEGLSKEDLEEQEFIIKRRVLGNIKFIGELYKHGVLGEKVAKAIVVQLITKCEERLDEESIEPLVKILNTIGKKLDEVDKANTDLYFSKVTNISNNPVVTSRGRFILLDLIDLRANKWQPKNSTQTKTKKDESDKEERFIAKHGGPQKRENDSRRDGGRDSRGDDRRGGGGRDSRGDDRRGGRDSRDAPRSAFGGKSSKDGWETVGAKGGNNRDKGGRGGDRSGGKQSPSGKKDSGFGPSSGGSSLFGSRRGDDRRDGGGNSSPYRPGQGFGRKDDQSSSIPSIPNRSNAFSALEDDDYQPSTSPQPPSVFGNRSNDRDSRGPSKPDNRKQPAQPPAPVEPVKPKINFEKIEDDISMTLDEYAETQDIDEAIECIKEINEPTVLGKQFNIFIMKSLERKEKEKQLIIELFSGILTAQLFNAEQIKEGLKEIIDTIEDIEIDLPFSGVFVATIVGICIESEIFPLNYLEEAYAHLVDSDKAEEMIVNTFNSIVKVSDKDRLVEIYENTKGLDILKLFALKNRKVAYLEEFYQTHFPYLSHEKAVEGSNESALNEQPDLIEHLLLLQSADGYWQLDKKLAGILGISLNILEEVDSSDSCVITTHPEVWATCLAITFVNLNNVSDPDDEDDLELVLSKSHKWLASQYQSDKPPKQSQDDVLLKAKRLLSEVL
What are the official names of this protein?
von Willebrand factor A domain-containing protein DDB_G0286969.
Protein: RNAS1_CAMBA
Sequence: SETAAEKFERQHMDSYSSSSSNSNYCNQMMKRREMTDGWCKPVNTFIHESLEDVQAVCSQKSVTCKNGQTNCHQSSTTMHITDCRETGSSKYPNCAYKASNLQKHIIIACEGNPYVPVHFDASV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: TMTA_ASPFU
Sequence: MSKSDYIQNMFQTKSFVDRYKYTEKLTGLYAQTLVDYSGVANTSQKPLVVLDNACGIGAVSSVLNHTLQDEAKKTWKLTCGDLSEGMLETTKRRLQDEGWVNAETKIVNALDTGLPDGHYTHVFVAFGFQSFPDANAALKECFRILASGGILASSTWQNFNWIPIMKAAIETIPGNLPFPTQKEFIALHNAGWDSESYIQSELEKLGFRDVKVIPVPKETSIPIDEFFEVCMMIIPYLLPKFWTEEQRESHEKDVPMVLRQYLQDTYGANGQVPLEAVALITTGLKP
What is the function of this protein?
S-methyltransferase that catalyzes the irreversible conversion of the secondary metabolite gliotoxin to bis(methylthio)gliotoxin (BmGT).  Gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins, is characterized by a disulfide bridged cyclic dipeptide.  Its thiol groups are essential for bioactivity, as they conjugate to sulfur-containing proteins, disturb the intracellular redox equilibrium, and generate reactive oxygen species by cycling between reduced and oxidized states.  The enzyme prevents self-intoxication of the fungus by irreversible conversion of the toxic gliotoxin to a biologically inactive bis-thiomethylated derivative.  Appears to negatively regulate gliotoxin biosynthesis.
What are the official names of this protein?
Gliotoxin thiomethyltransferase GtmA, Thiol methyltransferase tmtA, S-MT tmtA.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily.
Protein: VE7_HPV38
Sequence: MIGKQATLRDIVLEELVQPIDLHCHEELPDLPEDIEASVVEEEPAYTPYKIIVLCGGCEVRLKLYVWATDAGIRNLQDCLLGDVRLLCPTCREDIRNGGR
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.