PharMolix/UniProtQA huggingface dataset:
Protein: GCY35_CAEEL
Sequence: MFGWIHESFRQLVTRKYGKDIWEKIVHMSKFELGTESEIAHYYNDDETLRLVNSMANVIGIPIEEIWEAYGGFLIQFTMETGWDELLRAMAPDLEGFLDSLDSLHYFIDHVVYKTKLRGPSFRCDVQADGTLLLHYYSKRSGLYPIVKGVVREVARRIYDTEVVMKVQERKQEHLDAFVTEHVVFVITQIENANSTQPKSISSKADSQIDLSTGIYEISSSDFSLAFPYHICFDPDLFVEHFGNFIKKTFPNAMRQETRVTDLLELVHPEVPFSYESIKYYKNSLFVFRLKGLGDIVHNANDEAKTVLLKGSMVFIDEGKYILYMCSVNVTTVRELIERNLHLSDMQRHDGTRDVIMLNQSRMSQVELNRTLEETTKKLKKMAQELEIEKQKTDELLCELMPASVADSLRSGKAMDAKEFADCTLLFTDIVTFTNICAMCTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPERCENHAERVLNISIGMLMESKLVLSPITHKPIKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGIQCKIHVSETGKLNGLKANPSYVFIDRGNTEIRGKGMMYTYFLERNDRKSVWELCSRPRSGEQTIDGYMELHDQSIYQEEGGQQENLTVENGNSAQNNHNNNNNTHHSGRKLMNGSSVDPGSHHIRSPTCTIS
What is the function of this protein?
Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP.  Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity.  cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation.  Indeed, C. elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior.  Involved in avoidance of hyperoxia and for oxygen-induced aggregation and bordering, probably by mediating oxygen-sensing in URX, AQR and PQR sensory neurons.
What are the official names of this protein?
Soluble guanylate cyclase gcy-35.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, dendrite. Note=Enriched localization at the URX dendrite ending.
Protein: HIS3_CORDI
Sequence: MDDPASYELDPSIAQRVKFNSAGLVPAVVQSTDGEVLMLAWMDAHALAYTIATRKGTYFSRSRNEYWIKGLTSGHTQQVTGLQLDCDGDTVLMTVVQQGGACHTGDRTCFDADVII
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPRS5_ARATH
Sequence: MASIVQPSPTFPALNLRRSSLIRPPSSVRFPLKCNAADPYKFDGGNSAGFHLLTGDTVPASFSRTRLEDSIYQNTTRLRIFSGTANPILAQEISCYLGLDLGKIKIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLVMIDACRRASAKTITAVIPYFGYARADRKTQGRESIAAKLVANLITQSGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKAISSEDLVVVSPDVGGVARARAFAKKLSDAPLAIVDKRRHGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTISKGAALLHQEGAREVYACTTHAVFSPPAISRLSSGLFQEVIITNTIPLSEKNYFPQLTVLSVANLLGETIWRVHDDCSGAIEPFSTLGID
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase 5, chloroplastic, Phosphoribosyl pyrophosphate synthase 5.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y3423_BRUAB
Sequence: MKPKISFNNVVMRYGGFLALDRLNLDIADGEFVTVVGPSGCGKSTAMNIAAGLLQPSGGEILVGDKPVTGPGPERGVIFQQYALFPWLTVRQNVEFGLSVAGMSRVKRREISDHYLSLVGLTDFADALPKALSGGMKQRCAIARAYAAAPEILLMDEPFAALDALTRVHMQDQLLDAWSRERRTVMFITHDVDEAVYLANRVIVMAARPGRLDQIIPVDLPYPRTEAIRLSPEFAAIRNRVWHAVYHQQPQTDQQSSHGQ
What is the function of this protein?
Probably part of an ABC transporter complex.  Probably Responsible for energy coupling to the transport system (Probable).
What are the official names of this protein?
Putative ATP-binding protein BruAb2_1123.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MTHD_ARATH
Sequence: MLAKTVFPRGLLVLRSFSSVASKTLLKVGDVLRETRVFSSEDIKAYAEVSHDWNPLHFDPESARKAGFENRLVHGMLVSSMFPRIISAHFPGAVYVSQSLHFRSPVYIGDEILGLVQAIALRETKNKYIVKFSTKCFKNHNELVVIDGEATAILPNLDMLQKSPSE
What is the function of this protein?
3-hydroxyl-[acyl-carrier-protein] (3-hydroxyl-ACP) dehydratase required for mitochondrial fatty acid synthesis (mtFAS) (PubMed:28202596).  MtFAS are essential for photorespiration and plant development, probably by influencing mitochondrial membrane lipid composition and other lipid metabolic pathways (PubMed:28202596).
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase, mitochondrial, mtHD.
Protein: E13G_TOBAC
Sequence: MTLCIKNGFLAAALVLVGLLICSIQMIGAQSIGVCYGKHANNLPSDQDVINLYNANGIRKMRIYNPDTNVFNALRGSNIEIILDVPLQDLQSLTDPSRANGWVQDNIINHFPDVKFKYIAVGNEVSPGNNGQYAPFVAPAMQNVYNALAAAGLQDQIKVSTATYSGILANTYPPKDSIFRGEFNSFINPIIQFLVQHNLPLLANVYPYFGHIFNTADVPLSYALFTQQEANPAGYQNLFDALLDSMYFAVEKAGGQNVEIIVSESGWPSEGNSAATIENAQTYYENLINHVKSGAGTPKKPGKAIETYLFAMFDENNKEGDITEKHFGLFSPDQRAKYQLNFN
What is the function of this protein?
Implicated in the defense of plants against pathogens.
What are the official names of this protein?
Glucan endo-1,3-beta-glucosidase, acidic isoform GI9, (1->3)-beta-glucan endohydrolase, (1->3)-beta-glucanase, Beta-1,3-endoglucanase, PR-2B, PR-36.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: PURA_METC4
Sequence: MANVVVVGAQWGDEGKGKIVDWLSEQADVVVRFQGGHNAGHTLVVGEAVYKLSLLPSGVVRPNTLGVIGNGVVLDPYALASEIDRLAGQGVTVSRENLRVADNATLILSLHRELDALREDGAPGTKIGTTKRGIGPAYEDKVGRRAIRLMDLAEPETLPPKIERLLAHHNALRRGFGLEEISEQTILDELTGIAERVLPYQDTVWRLLDDARRGGKRILFEGAQGALLDVDHGTYPFVTSSNTVAGQAATGSGLGPRAIGYVLGIAKAYTTRVGEGPFPTELHDEIGQRIGERGHEFGTVTGRKRRCGWFDACLVRQTVKTSGIDGIALTKLDVLDGFDEIRVCTAYDIDGQRFDHLPASQAAQQRAVPVYETIPGWSGTTAGARSWADLPAQAIKYVRRIEELIGAPVALLSTSPERDDTILMHNPFED
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSP4_BOVIN
Sequence: MLAPRGATFLLLHLALQPWLGAGAQATPQVFDLLPSASQRLNPSVLQPILTDPTLNELYVISTFKLQSKSSATIFGLYSSADHSKYFEFTVMGRLNKAILRYLKNDGRIHLVVFNNLQLADGRRHRLLLRLTNLHRGAGSVELFLDCTRVDSIHNLPRAFSGLAQSPEAVELRTFQRKAHDSLEELKLVVRGSLIQVASLQDCFLQQSEPLATTNTGDFNRQFLGQMSQLNQLLGEVKDLLRQQVKETSFLRNTIAECQACGPLSFQSPTPNTLMPVVPAASPTPPVRRCDSNPCFRGVRCTDTRDGFQCGPCPEGYTGNGIVCSDVDECRYHPCYPGVRCVNLAPGFRCDACPVGFTGPMMQGVGISFAKTNKQVCTDIDECRNGACVLNSICINTLGSYRCGPCKPGYIGDQMRGCKMERNCRDPELNPCSVNAQCIEERQGDVTCVCGVGWAGDGYICGKDVDIDSYPDEELPCSARNCKKDNCKYVPNSGQEDADRDGIGDACDDDADGDGILNEQDNCVLTHNVDQRNSDKDIFGDACDNCRNVLNNDQKDTDGDGKGDACDDDMDGDGIKNILDNCQKVPNSDQEDRDGDGVGDACDSCPEVSNPNQSDVDNDLVGDSCDTNQDSDGDGHQDSTDNCPTVINSAQLDTDKDGIGDECDDDDDNDGIPDLVPPGPDNCRLVPNPAQEDSNSDGVGDICEADFDQDQVIDRIDVCPENAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTQTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVKSKTGPGEHLRNSLWHTGDTSDQVRLLWKDSRNVGWKDKVSYRWFLQHRPQVGYIRVRFYEGSELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIPEDFQEFQTQNFDRLDK
What is the function of this protein?
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling.  Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling.  Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload.  May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury.  May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).
What are the official names of this protein?
Thrombospondin-4.
What is the protein family that this protein belongs to?
Belongs to the thrombospondin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Sarcoplasmic reticulum. Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix.
Protein: VIRA_SHIDS
Sequence: MQTSNITNYERNDSSWMSTVKSTTEVSWNKLSFCDVLLKIITFGIYSPHETLAEKYSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKGICSVFYLDGDKIQSTQLSSKEYNNLLSSLPPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFSVKDTDFNSVWHDIYRDIRASDSNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQMLSYNQVNKIINSNFPQQDLCFQTEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPEQRVINNCGHIIKINAVVPKNDTAISASGGRAYEVSSSILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPESRQVSFAIISPDV
What is the function of this protein?
Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading.  Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles.  The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks.  Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure.  This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell.  Is absolutely required for virulence (By similarity).
What are the official names of this protein?
Cysteine protease-like VirA, Effector protein VirA.
What is the protein family that this protein belongs to?
Belongs to the protease EspG/VirA family.
What are the subcellular locations of this protein?
Secreted. Note=Translocated into the host cell via the type III secretion system (TTSS). Localizes in the cytoplasm of the infected cell (By similarity).
Protein: TXVE_BOTER
Sequence: MAAYLLAVAILFCIQGWPLGTVQGQVMPFMEVYRHSVCQPRETLVSILEEYPGEIAHIFRPSCVTALRCGGCCTDESLECTATGKRSVGREIMRLSPHKGTSEKEVMQFTEHTDCECRPRSASGVNSRKHKRNPEEGEQRAKFPFV
What is the function of this protein?
Snake venom VEGFs that may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension.  This protein induces an increase in capillary permeability after intradermal injection, as well as a drastic hypotensive effect after intravenous injection (By similarity).  The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase.  Also induces angiogenesis in vitro (By similarity).  Like other crotalid VEGFs, this protein interacts with VEGF receptor-1 (FLT1) with a high affinity, whereas it binds to VEGF receptor-2 (KDR) with a low affinity (By similarity).
What are the official names of this protein?
Snake venom vascular endothelial growth factor toxin, svVEGF, VEGF-F.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family. Snake venom VEGF subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MTMB2_METBA
Sequence: MTFRKYFDCYDFYDRAKVGEKCTLDDWDLMKIPMKAMELKQKYGLDFKGEFIPTDKDMMEKLFKAGFEMLLECGIYCTDTHRIVKYTEDEIWDAINNVQKEFVLGTGRDAVNVRKRSVGDKAKPIVQGGPTGSPISEDVFMPVHMSYALEKEVDTIVNGVMTTVRGKAPIPKSPYEVLAAKTETRLIKNACAMAGRPGMGVOGPETSLSAQGNISADCAGGMTCTDSHEVSQLCELKIDLDAISVIAHYTANSDIIMDEQMPIFGGYAGGIEETTIVDVATHINAVLMSSASWHLDGPVHIRWGSTNTRETLMIAGWACATISEFTDILSGNQYYPCAGPCTEMCLLEASAQSITDTASGREILSGVASAKGVVTDKTTGMEARMMGEVARATAGVEISEVNVILDKLVALYEKNYASAPAGKTFQECYDVKTVTPTDEYMQVYDGARKKLEDLGLVF
What is the function of this protein?
Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC (MtmC1 or MtmC2).
What are the official names of this protein?
Monomethylamine methyltransferase MtmB2, MMA methyltransferase 2, MMAMT 2.
What is the protein family that this protein belongs to?
Belongs to the monomethylamine methyltransferase family.
Protein: CYB_LUTLU
Sequence: MTNIRKTHPLAKIINNSLIDLPAPSNISAWWNFGSLLGTCLILQILTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWIIRYMHANGASMFFICLFLHVGRGLYYGSYMFPETWNTGIILLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTSLVEWIWGGFSVDKATLTRFFAFHFILPFIILALATIHLLFLHETGSNNPSGIPSNSDKIPFHPYYTIKDILGALLLALMLMMLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAIIPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPAEHPFITIGQLASILYFTLLLILMPIASIIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PLE3_CLIPA
Sequence: MGLSEDLHARARTLMQTLESALNTPGSRGIGTANPTIYDTAWVAMVSREIDGKQVFVFPETFTYIYEHQEADGSWSGDGSLIDSIVNTLACLVALKMHESNASKPDIPARARAAQNYLDDALKRWDIMETERVAYEMIVPCLLKQLDAFGVSFTFPHHDLLYNMYAGKLAKLNWEAIYAKNSSLLHCMEAFVGVCDFDRMPHLLRDGNFMATPSTTAAYLMKATKWDDRAEDYLRHVIEVYAPHGRDVVPNLWPMTFFEIVWSLSSLYDNNLEFAQMDPECLDRIALKLREFLVAGKGVLGFVPGTTHDADMSSKTLMLLQVLNHPYSHDEFVTEFEAPTYFRCYSFERNASVTVNSNCLMSLLHAPDVNKYESQIVKIATYVADVWWTSAGVVKDKWNVSEWYSSMLSSQALVRLLFEHGKGNLKSISEELLSRVSIACFTMISRILQSQKPDGSWGCAEETSYALITLANVASLPTCDLIRDHLYKVIESAKAYLTPIFYARPAAKPEDRVWIDKVTYSVESFRDAYLVSALNVPIPRFDPSSISTLPAISQTLPKELSKFFGRLDMFKPAPEWRKLTWGIEATLMGPELNRVPSSTFAKVEKGAAGKWFEFLPYMTIAPSSLEGTPISSQGMLDVLVLIRGLYNTDDYLDMTLIKATNEDLDDLKKKIRDLFADPKSFSTLSEVPDDRMPTHIEVIERFAYSLLNHPRAQLASDNDKGLLRSEIEHYFLAGIAQCEENILLRERGLDKERIGTSHYRWTHVVGADNVAGTIALVFALCLLGHQINEERGSRDLVDVFPSPVLKYLFNDCVMHFGTFSRLANDLHSISRDFNEVNLNSIMFSEFTGPKSGTDTEKAREAALLELTKFERKATDDGFEYLVQQLTPHVGAKRARDYINIIRVTYLHTALYDDLGRLTRADISNANQEVSKGTNGVKKINGSSTNGTKVTANGSNGIHH
What is the function of this protein?
Bifunctional premutilin synthase; part of the gene cluster that mediates the biosynthesis of pleuromutilin, a tricyclic diterpene showing antibacterial properties (PubMed:27143514, PubMed:29388775).  The geranylgeranyl diphosphate (GGPP) synthase catalyzes the first step in pleuromutilin biosynthesis (PubMed:27143514, PubMed:29388775).  GGPP is then substrate of the premutilin synthase (PS) to yield premutilin (PubMed:29388775).  Premutilin synthase is a bifunctional enzyme composed of the fusion of a class II diterpene cyclase (DTC) and a class I diterpene synthase (DTS), with the corresponding domains and active sites containing characteristic aspartate-rich motifs.  GGPP is first converted to mutildienyl-diphosphate (MPP) at the class II DTC site (PubMed:29388775).  MPP is subsequently further cyclized at the class I DTS site, followed by a 1,5-hydride shift and addition of water prior to terminating deprotonation, to yield premutilin (PubMed:29388775).  In addition to the aforementioned GGPP synthase and bifunctional diterpene synthase, the cluster contains also three cytochrome P450 monooxygenases, a short-chain alcohol dehydrogenase, and an acyltransferase, involved in the conversion of premutilin to pleuromutilin (PubMed:27143514, PubMed:29388775).  The cytochrome P450 monooxygenases P450-1 and P450-2 hydroxylate premutilin at C-11 and C-3, respectively, producing 11-hydroxypremutilin and 3-hydroxypremutilin (By similarity).  The combination of the actions of both ple5 and ple6 leads to the production of 3,11-dihydroxypremutilin (By similarity).  The short chain dehydrogenase SDR further converts 3,11-dihydroxypremutilin into mutilin (By similarity).  The acetyltransferase ATF then acetylates mutilin to produce 14-O-acetylmutilin (By similarity).  Finally, the cytochrome P450 monooxygenase P450-3 catalyzes hydroxylation on the alpha position of the acetyl side chain of 14-O-acetylmutilin to yield pleuromutilin (By similarity).
What are the official names of this protein?
Bifunctional premutilin synthase, PS.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: PRS6B_ASPNG
Sequence: MGDVAVETPANNVTPLTKAAPLDTIPNIDSLEGTGNDGSDEYATLKRLQRHLEYIQLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNALVDILPPEADSSIAMLGENEKPDVTYADVGGLDMQKQEIREAVELPLTQFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVNGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFEQSSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFSTIASKMSLSPEVDLDSLIVRNEPLSGAVIAAIMQEAGLRAVRKNRYNIIPRSDLEDAYAAQVKTGQEADRLEFYR
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
What are the official names of this protein?
26S proteasome regulatory subunit 6B homolog.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: KDPC_BURP1
Sequence: MKSLFRPLIVVFVVLVAVTGLAYPAVMTVFGQAVFPAQANGSLIEKGGRVVGSALIGQQFDAPQYFWGRLSATSPMPYNAAGSGGSNLGPLNPALKDQVKSRLDALKAAGTDLSQPVPVDLVTASASGLDPEISPAAADYQVARVARARKMADADVRRLVADHTSGRQFGVLGEPRVNVLKLNLALDAAQAAH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: APT_YERP3
Sequence: MTASASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESGVTKVVGTEARGFLFGAPVALALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSIQPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFIINLPELGGEARLTQQGIHCYSLVSFDGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HH_DROSE
Sequence: MDNHSSVPWASAASVTCLSLDAKCHSSSSKSAASSISASPETQTMRHIAHTQRCLSRLTSLVALLLIVLPMMFSPAHSCGPGRGLGRHRARNLYPLVLKQTIPNLSEYTNSASGPLEGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTDGGAVLTVTPAHLVSVWQPESQKLTFVFADRIEEKNQVLVRDVETGELRPQRVVKVGSVRSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWLPAKEQLHSSPKVVSSAQQQNGIHWYANALYKVKDYVLPQSWRHD
What is the function of this protein?
The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.  Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks.  Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc.  In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu).  Essential component of a signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection.  During photoreceptor differentiation, it up-regulates transcription of Ubr3, which in turn promotes the hh-signaling pathway by mediating the ubiquitination and degradation of cos.
What are the official names of this protein?
Protein hedgehog.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. SUBCELLULAR LOCATION: [Protein hedgehog N-product]: Cell membrane; Lipid-anchor. Note=The N-terminal peptide remains associated with the cell surface. Heparan sulfate proteoglycans of the extracellular matrix play an essential role in diffusion. Lipophorin is required for diffusion, probably by acting as vehicle for its movement, explaining how it can spread over long distances despite its lipidation.
Protein: RDRP_AQRVC
Sequence: MEELFNALPQPLQQLSLALAGEIPLTDHIFEQAASTWHVQPRSLTYKLLDHIPFSTPVVVPPSIYHSLDWSKCFAVNQDRVERVPTIDDPDDVYVPNSDIGPLLTSLHTIPDYGFLHPAIENDATTLRAERARCASTFYKIASSQARQVKLDPIRMLGFLLLVQARPRVPSGLVTDQPTRRDPTQSPALHAIWQVMQYYKVAGVYYAPALVVPSGAIWWIPPPGKRNVVSVQYLLTDLINLAILAHMTDMSPTLELTGVLMYLRAASSHSHAYTLLQMKSVFPALSLRSMYRNKGFGGKAPAIEWTEPRSKYKFRWTGVTQLHDGLRPRSPSMDVPTLEVLTKYELVDIGHIIIRERNAHPRHNHDSVRFVRDVMALTSGMYLVRQPTMSVLREYSQVPDIKDPIPPSAWTGPIGNVRYLLPSVQGPARHLYDTWRAAARQIAQDPQWHDPLNQAIMRAQYVTARGGSSASLKFALKVTGIVLPEYDDSKVKKSSKIYQAAQIARIAFMLLIAAIHAEVTMGIRNQVQRRARSIMPLNVIQQAISAPHTLVANYINKHMNLSTTSGSVVTDKVIPLILYASTPPNTVVNVDIKACDASITYNYFLSVICGAMHEGFEVGNADAAFMGVPSTIVSDRRSSVAPYSRPISGLQTMVQHLADLYAAGFRYSVSDAFSSGNKFSFPTSTFPSGSTATSTEHTANNSTMMEYFLNVHAPSHVKSASLKRILTDMTIQRNYVCQGDDGILLLPHEAASKISADDMNELLTCLRDYGQLFGWNYDIDWSDTAEYLKLYALMGCRIPNTSRHPPVGKEYAAPQTDEIWPSLIDIVIGHHLNGVTDVLNWREWLRFSWAFACYSSRGGYTNPKGQSFSAQYPWWTFVYLGIPPILLPGQTPFIHSCYMPPGDQGMFSILNGWRDWLISHASTTLPPLRHNHPVWGLSDVPSLLSQFGVYAGYHAAQHYRRPKPAPETASSDSINQITSDLTEYLFYDSALKARVMKGRYNWERLSSSLSLNVGSRVPSLFDVPGKWVAAGRDAEKPPPSSVEDMFTSLNRCIRRPTHSFSRLLELYLRVHVTLGESIPLAIDPDVPQVAGADPANDDHWFKYTCLGDIPSATRNYFGESLFVGRVVSGLDVEAVDATLLRLKILGAPPEAFIAVLNGIGMSDSEAHQIAGRISLANAQLVQIARVVHLSIPSSWMTLNTGPYIHHHAYDFKPGITQPSAKSRDKSIWMSPILKLLCTSYAMTVAGPVRTSIVTEIDGSAAALSGNLRVWMRDV
What is the function of this protein?
RNA-directed RNA polymerase that is involved in transcription and genome replication.  Following infection, it catalyzes the synthesis of fully conservative plus strands.  After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase VP2.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion.
Protein: RL30_META3
Sequence: MAYAVVRIRGSVGVRGSIADTLKMLRLHKVNHCVIIPNTETYNGMINKAKDFITYGEIDKDTLIKMILKRGRLSGNRRIDQETVKELMGMSVEELAEKIVNEEILLKDTPIKPVFRLHPPRKGHNKAGIKKSFTVGGALGYRGEKISELLKKMI
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.