PharMolix/UniProtQA huggingface dataset:
Protein: HUTH_BARQU
Sequence: MTIVLNPGKVTLNQLEAIYWNGEVSKLHNDTHLAIRKGADRIAEIAAGSQPVYGINTGFGKLASIKIDANDVAVLQRNLILSHCCAVGAPLAENIVRLMMTLKLISLGRGASGVRLELVHLLESMLAKGVIPVIPEKGSVGASGDLAPLAHMVAVMIGEGEAFFQNIRMSGAAALEKARLFPITLEAKEGLALINGTQTSTALALAGLFQGYRALCGGLLAGALTTDAVMGSTAPFHPDIHILRGHYGQIVVSQTLEKLIKDSEIRAAHLCDDDHRVQDPYCIRCQPQVMGACFDVLVAAAKTLIIEANAVTDNPLILSNGEVVSGGNFHAEPVAFSADQIALALCEIGSISQRRIALMVDPTVSCGLPPFLAQNAGLNSGFMIAEITAAALMSENKQMAHPASVDSTPTSANQEDHVSMACHGARRLLAMNENLFTIIGIETLAAAQGIEYRAPLKTSSLLQSVMKRLRKNIDTLKVDRYLAPDLHKAHILVREGHLLSVLPEIFPRLEPQ
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_LEVBA
Sequence: MEYSEIMVRYGELSTKGKNKKDFIKQLGQNTRKALHQFDGIEVKAQHDRLHVTLNGADSTAVMDRLKGVFGIENFSPSVKVEKDIAAIKATALAMVQEIFTPGMTFKINTRRQDKQFEYDTNHLNDLLGGYILENVPGIQVKMKQPDLTLRVEVRLNGVFLSGQTIQGAGGLPVGTGGKAVMMLSGGIDSPVAAYYGMRRGVKLDMVHFFSPPYTSEQALAKAKELTARLAGYSGSIQFIQVPFTKIQETIKEKVPEGYLMTIQRRLMLRLAAAVAERRHAKGIFNGESLGQVASQTLESMAAINDVTSMPILRPLLSMDKTEIIKVAENIDTYDLSILPYEDCCTIFTPPAPKTHPDLEKSRKYEKYIDVDGLMQEALDGMIITDIHPDDNYLNQNEDVFAELL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETK_ECO57
Sequence: MTTKNMNTPPGSTQENEIDLLRLVGELWDHRKFIISVTALFTLIAVAYSLLSTPIYQADTLVQVEQKQGNAILSGLSDMIPNSSPESAPEIQLLQSRMILGKTIAELNLRDMVEQKYFPIVGRGWARLTKEKPGELAISWMHIPQLNGQDQQLTLTVGENGHYTLEGEEFTVNGMVGQRLEKDGVALTIADIKAKPGTQFVLSQRTELEAINALQETFTVSERSKESGMLELTMTGDDPQLITRILNSIANNYLQQNIARQAAQDSQSLEFLQRQLPEVRSELDQAEEKLNVYRQQRDSVDLNLEAKAVLEQIVNVDNQLNELTFREAEISQLYKKDHPTYRALLEKRQTLEQERKRLNKRVSAMPSTQQEVLRLSRDVEAGRAVYLQLLNRQQELSISKSSAIGNVRIIDPAVTQPQPVKPKKALNVVLGFILGLFISVGAVLARAMLRRGVEAPEQLEEHGISVYATIPMSEWLDKRTRLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGATPDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKVIQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVVGRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGYSYSEKE
What are the official names of this protein?
Tyrosine-protein kinase etk.
What is the protein family that this protein belongs to?
Belongs to the etk/wzc family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RGGC_ARATH
Sequence: MASLNPFDLLGDDAEDPSQLAVALSQKVEKAAAAVQPPKAAKFPTKPAPPSQAVRESRNAPQGGRGGTGGRGGFSRGRGNGGYNRDNRNNDAPGNENGFSGGYRRPSEDADGASRGGSVGGYRVGGGREGPRRGGVANGESGDVERPPRNYDRHSRTGHGTGMKRNGGGRGNWGTTEDDIPPTSEEPTTEVEKSPVAEKQGGEDETPEAKKELTAEEKAQKEAEEAEAREMTLEEYEKILEEKKKALQATKVEERKVDTKVFESMQQLSNKKNTDEEIFIKLGSDKEKRKDATEKAKKSLSINEFLKPADGKRYNGRGGGSRGRGGRGGRGEGGNQRYAKEAAAPAIGDTAQFPSLG
What is the function of this protein?
Binds RNA.
What are the official names of this protein?
RGG repeats nuclear RNA binding protein C.
What is the protein family that this protein belongs to?
Belongs to the RGGA protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region.
Protein: THIM_BACC2
Sequence: MNMKEISKVVDLVRESNPLVHNITNVVVTNFTANGLLALGASPVMAYAKEEVAEMANIAGALVLNMGTLRPEEVEAMLLAGKSANVNNVPVLFDPVGAGATSYRTEVARHIPAEIDLAIIRGNAAEIANVINEKWEIKGVDAGTGNGNVVSIARQAADELNTVAVITGKEDVVTDGERTVLIRNGHPILTKVTGTGCLLTSVIGAFVAVEKDYVKAVVAALTFYGVAAELAAVKTVEKGPGSFQIEFLNQLANTTSADIEKYGKIEELE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: MUTS2_STRZJ
Sequence: MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLTSRELQSFYANLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHDSESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKAVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFIDQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: RPOA_STRP1
Sequence: MIEFEKPIITKIDENKDYGRFVIEPLERGYGTTLGNSLRRVLLSSLPGAAVTSIKIDGVLHEFDTIPGVREDVMQIILNVKGLAVKSYVEDEKIIELEVEGPAEVTAGDILTDSDIELVNPDHYLFTIAEGHSLRATMTVAKKRGYVPAEGNKKDDAPVGTLAVDSIYTPVKKVNYQVEPARVGSNDGFDKLTIEIMTNGTIIPEDALGLSARVLIEHLNLFTDLTEVAKATEVMKETEKVNDEKVLDRTIEELDLSVRSYNCLKRAGINTVFDLTEKSEPEMMKVRNLGRKSLEEVKVKLADLGLGLKNDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RS3_PELPB
Sequence: MGQKVNPTGFRLGIIRDWASRWYDDSPVISEKIKQDHVIRTYVLARLKKERAGIARIIIERTTKHVKINIYAARPGAVVGRKGEEINNLSQELSRITGKEVKIDVVEVVKPEIEAQLIGDNIAYQLENRVSFRRAMKQAIQQAMRSGAEGVRIRCGGRLGGAEIARSEQYKEGKIPLHTIRANVDYASVTAHTIAGTIGIKVWVYKGEVLVQRIDAIEEDELKRIKERRNDAGARNRDSRTKRRHRTKR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: GANA_ASPNC
Sequence: MIYSLLLSALPLLSSAALTYRGADISSLLIEEDAGISYKNLNGETQALEDILVNNGVNSIRQRVWVDPSDGSYDLDYNLKLAKRVQAAGMSIYLDLHLSDTWADPSDQTTPTGWSTTDIDTLTWQLYNYTLDVCNTFAENDIDIEIVSIGNEISSGLLWPLGKTSNYDNIAKLLHSGAWGVKDSNQATTPKIMIHLDNGWDWEEQEYFYKTVLATGSLLSTDFDLMGVSYYPFYSSEATLSALQTSLTNMQSNYDKSVVVVETNWPVSCPDPEYSFPSDLSSIPFSAAGQEEFLEKLAEVVEGVTDGLGIYYWEPAWVDNAALGSSCADNLMVDIDTDEVLESVTVFEDL
What is the function of this protein?
Endogalactanase involved in the degradation of plant cell wall polysaccharides, and more particularly of hairy regions of pectin.
What are the official names of this protein?
Probable arabinogalactan endo-beta-1,4-galactanase A, Endo-1,4-beta-galactanase A, Galactanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 53 family.
What are the subcellular locations of this protein?
Secreted.
Protein: VATA_MAIZE
Sequence: ARATIQVYEETAGLMVNDPVLRTRKPLSVELGPGILGNIFDGIQRPLKTIAIKSGDVYIPRGVSVPALDKDVLWEFQPTKLGVGDVITGGDLYATVFENTLMQHHVALPPGSMGKISYIAPAGQYNLQDTVLELEFQGIKKKFTMLQTWPVRSPRPVASKLAADTPLLTGQRVLDALFPSVLGGTCAIPGAFGCGKTVISQALSKYSNSEAVVYVGCGERGNEMAEVLMDFPQLTMTLPDGREESVMKRTTLVANTSNMPVAAREASIYTGITIAEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLAARLASFYERAGKVKCLGSPDRNGSVTIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLISYSKYSKALESFYEKFDPDFIDIRTKAREVLQREDDLNEIVQLVGKDALAESDKITLETAKLLREDYLAQNAFTPYDKFCPFYKSVWMMRNIIHFNTLANQAVERAAGTDGHKITYSVIKHRLGDLFYRLVSQKFEDPAEGEEALVGKFKKLYDDLTTGFRNLEDEAR
What is the function of this protein?
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase.  V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase catalytic subunit A, V-ATPase subunit A, V-ATPase 69 kDa subunit, Vacuolar proton pump subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: MSH3_ASPCL
Sequence: MPLRSSQSSPPASQSFKRKQPTISSFFTKKPPTSQEKAQEPEDEPAASRRQFANALDKATRVKEHGAPAERDEEQEEEEEDIVAPAPKRIKTNGVHEKEPASAAKEVSSASRPAPPLASSQRTELYKFASSPADGAGAGVDRPEDPETKQRQAERERLHQLFVKKLGGADCAVGIGRSAGGDAPSGAEEAAEGDEDEEVAPAPAAKGRGSKKAGGGKLTPLEKQVIEIKRKHMDTVLVIEVGYKYRFFGEDARIAAKELSIVCIPGKMRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVAAGYKVGVVRQLETAALKAAGDNRNAPFSRKLTNLYTKGTYVDDVEGLEGPTPAASGGASPATGYLLCITETNAKGWGNDERVHVGIVAVQPNTGDIIYDDFEDGFMRSEVETRLLHIAPCELVIVGELSKATEKLVQHLSGSKLNTFGDKVRVERVGKKKTAVAESHSHVANFYASKLKAASVDDTQTSNLLQKVLTLPEQVTVCLSAMIEHMTEYGLEHIFQLTKYFQHFSSRSHMLLNANTLVSLEIYQNQTDHSTKGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKSRLEERVNAVEELKNPEKTVQVERLKRLLGRIKSDLEKNLIRIYYGKCTRPELLTVLQTLQTIAQEYADVKSPEDNGFASPVLGEAVASLPTILKDVVAFLNKINMHAARSDDKYEFFRESEETDEISEHKLGIASVEHELEEHRAVAAGILKWPKVVYVTSSGIEYLIEVENTSNAIKRVPASWVKVSGTKKLSRFHTPEVIQLLRQRDQHKEALAAACDKAFAALLAEIAVNYQLFRDCVQALATLDCLLSLAAIASQPGYVKPEYTDHTCICVEQGRHPMVEQLLLDSYVPNDTDLDTDQTRALLVTGPNMGGKSSYVRQVALIAIMGQIGSYVPARSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRTIRSLTLFITHYQHLSNMTQSFPDHELRNVHMRFTESGAGQDEEITFLYEVGEGVAHRSYGLNVARLANLPAPLLDVAKLKSAELEEQIRRRRLARLLTAVGEVMSDPAKGDEDFLERLMSTAEQL
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  Msh3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein msh3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PER1_SCHPO
Sequence: MRVLRNFTIFFLFTALSLFRQISASAGDLHPVYVSCVNRCIENKCHGNPSDTSKLPLDLKLFRWDCGSNCGYECEITAENYFAAHNLPSQQYHGKWYFIRVFGIQELFSVFFSMLNFMIHYNGYHIMRRCIPDEHPAKRLCLSWAIVGMNAWVWSSVFHIRDTPITEKLDYFSAGAFVLFGSYCTLILMLRLDQLPGGKLLCWIIGVIFIAAFIAHVSYLSFYSFDYGYNMKANVAVGLVQNILWYYYSWSNRNSGLYWTRWPAYIVTSLMLATSLELFDFSPIANLIDAHALWHLSTVPITHYLYGFVVRKCSYDLTKGTFKIKAYDSSR
What is the function of this protein?
Involved in the lipid remodeling steps of GPI-anchor maturation.  Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins.  Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI.  Required for efficient transport of GPI-anchor proteins (By similarity).
What are the official names of this protein?
Protein PER1 homolog.
What is the protein family that this protein belongs to?
Belongs to the PGAP3/PER1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: RS3_MYCBP
Sequence: MGQKINPHGFRLGITTDWKSRWYADKQYAEYVKEDVAIRRLLSSGLERAGIADVEIERTRDRVRVDIHTARPGIVIGRRGTEADRIRADLEKLTGKQVQLNILEVKNPESQAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRQPNVKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKVWIYKGDIVGGKRELAAAAPAGADRPRRERPSGTRPRRSGASGTTATGTDAGRAAGGEEAAPDAAAPVEAQSTES
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: DSP4_CASSA
Sequence: MFCVQNLPRSSALPLQSFKSHQRRPPCSVNTLGVMSNVNLHRSMAVKAISGPTSSAETSDANVEEEKSETYSTNMTEAMGAVLTYRHELGINYNFIRPDLIVGSCLQTPEDVDKLRSIGVKTIFCLQQNSDLEYFGVDINGIREYAKTYDDIQHLRAEIRDFDAFDLRVRLPAVVSKLYKAINRNGGVTYVHCTAGLGRAPAVTLAYMFWVQGYKLIEAHNLLQSKRSCFPKLDAIKSAAADILTGLRKKVVTLTWKNPDCTTLEISGLDIGWGQRIPLQFDEEQGLWILRRELAEGCYEYKYIVDGEWTINENELVTSANKDGHVNNFVQVFDDNPDSFNANLRKRLTGDDPDLSMDERLKIRQFLESIPDEEQ
What is the function of this protein?
Starch granule-associated phosphoglucan phosphatase involved in the control of starch accumulation.  Acts as major regulator of the initial steps of starch degradation at the granule surface.  Functions during the day by dephosphorylating the night-accumulated phospho-oligosaccharides.  Can release phosphate from both the C6 and the C3 positions (By similarity).
What are the official names of this protein?
Phosphoglucan phosphatase DSP4, amyloplastic, Dual specificity protein phosphatase 4, CsDSP4.
What are the subcellular locations of this protein?
Plastid, amyloplast. Nucleus. Note=In dormant or cold-stressed trees, localizes to both the amyloplast stroma and nucleus. In conditions of vegetative growth, detected in the nucleus only.
Protein: HIS4_CYAP4
Sequence: MDIIPAIDLLGGRCVRLYQGDYNQAEVFDTDPVGMARRWLSQGATRLHLVDLDGAKTGEPVNQAAMAAIVQDLAIPVQVGGGVRSRQRVVELLDLGVDRVILGTVAIEQPQLVEALCAEFPGRILIGIDARDGKVATRGWLETSTVQATDLARTVEKAGAAGIIYTDIHRDGTLQGPNLEALRQLASEVNLPIIASGGVSSIADLLNLFVLSTSGVTGVIIGKALYSGDITLTDAIRAVGQGRWQDVPPDLGFSTFA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCPB_STAHJ
Sequence: MDKHGIIESLLYTAGDEGLDEKQLLEILEINQAKLSELISSYTSSGLIIQKFGSTYILTSKKEASPYIEQLIEQKSNMKLSQAAMETLSIIAYNQPLSRSDIELIRGINSDGAVRTLIARGLIEAKDVENSRSHALQTTDLFLNVFGIEKIEDLPTTEEDEEEMDDFFSNLVNQKGDTK
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: PSA3_RAT
Sequence: MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDVREEAEKYAKESLKEEDESDDDNM
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).  Binds to the C-terminus of CDKN1A and thereby mediates its degradation.  Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
What are the official names of this protein?
Proteasome subunit alpha type-3, Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8, Proteasome subunit K.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: SBNA_STAAS
Sequence: MIEKSQACHDSLLDSVGQTPMVQLHQLFPKHEVFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLITENTHLIESTSGNLGIALAMIAKIKGLKLTCVVDPKISPTNLKIIKSYGANVEMVEEPDAHGGYLMTRIAKVQELLATIDDAYWINQYANELNWQSHYHGAGTEIVETIKQPIDYFVAPVSTTGSIMGMSRKIKEVHPNAQIVAVDAKGSVIFGDKPINRELPGIGASRVPEILNRSEINQVIHVDDYQSALGCRKLIDYEGIFAGGSTGSIIAAIEQLITSIEEGATIVTILPDRGDRYLDLVYSDTWLEKMKSRQGVKSE
What is the function of this protein?
Catalyzes the synthesis of N-((2S)-2-amino-2-carboxyethyl)-L-glutamate (ACEGA) from O-phospho-L-serine and L-glutamate.  Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics.
What are the official names of this protein?
N-(2-amino-2-carboxyethyl)-L-glutamate synthase, ACEGA synthase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.
Protein: MNMG_UREP2
Sequence: MKKYDVIVIGAGHAGLEAAFATSNLNLQTALITLDEKGIGMMPCNPSIGGPAKGIVTREIDALGGIQGKAADATTMQMKILNSSKGPGVWAIRAQIDKIAYQRWFKQQIKQQKNLDLIIAEVSDLLVENNIVKGVVLSDQKIIQADYVIITTGTYLKSITHRGSVCVDEGADGTKNAKFLSDALVKLGFELIRLKTGTPARIKKDSIDFTNMILEPGTNQKIAFSHYHPVYKPYDEQLPCHIIYTNEQTHQIIRENLNKSAMYGGMISGIGPRYCPSIEDKIVKFSEKPRHQIFVEPESYELDSMYLGGFSTSMPIDVQEKMIRSLPGLENCEILKYAYAIEYDAIDPTQLYPSLESKLVNNLFFAGQINGTSGYEEAAAQGLMAAINVNQKYQNKEPVILGRDQAYIGVMIDDIVTKGVVEPYRLLTSRAEHRLALRNDNADDRLMKIGFEIGLLKPEVYDQYLNNLKQIKEILNWLKTTTVGQIDDLKFTTLKTNSYLIDYLKRPEIKLNDLLIYCPIKIEDEQIINKVQIQVKFEGYIKNQEENLKQLKRLNNIKLHAIVDYKEVPNISLETIDKLNKIKPLDLEQASRISGVNLTDIAMIKYYLERIKND
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYN2_RAT
Sequence: MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEYAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGRKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELISTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESAEQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQNTSSHSPTPQRRPVSSVHPPGRPPAVRGPTPGPPLIPMPVGATSSFSAPPIPSRPGPQNVFANNDPFSAPPQIPSRPARIPPGIPPGVPSRRAPAAPSRPTIIRPAEPSLLD
What is the function of this protein?
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP.  Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (PubMed:21210813).  Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed:19995918).  Involved in cytokinesis (PubMed:21195118).  Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).
What are the official names of this protein?
Dynamin-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction. Postsynaptic density. Synapse. Midbody. Membrane, clathrin-coated pit. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein. Note=Microtubule- associated. Also found in the postsynaptic density of neuronal cells (By similarity). Colocalizes with CTTN at the basis of filopodia in hippocampus neuron growth zones (PubMed:21210813). Co-localizes with PIK3C3 and RAB5A to the nascent phagosome (By similarity). SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasmic vesicle, clathrin-coated vesicle. Membrane, clathrin-coated pit. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane.
Protein: SPEA_GLOVI
Sequence: MQDWTIEDSAELYQIHGWGEPYFKINDKGHVAVMPRGEGNGEIDLFHLVQDIQKRGLNMPMLIRFSDILADRIARLNACFVEAIREYDYPGIYKGVYPVKVNQQRHVVEEVVEFGRPFQYGLEAGSKPELLIALATLKTPGALIICNGYKDSEYIETALLAQRLGHTPFVVIERFHELTLLIEAAQKLGIRPLIGVRAKLTARGIGRWGDSTGDRAKFGLSAGEIMEVVAQLKAADLLSSLQLLHFHIGSQISAINVIKTALREASCVYVELAQMGAPMQYCDVGGGLAIDYDGSKTNFRASKNYNMQEYAYDVVAAFQDACRTKNVPVPTLVSESGRAITSHQSVLVFDVMGVSHLQFGEPEPPARNEHSIIRNLYETYTQITPDNVQEAFNDASQFKEEALSLFALGYLGLGERARAERLYWGCCEKILNLVRELDYIPDELADLEKNMASTYYCNFSVFQSAPDSWAIDQLFPIMPIHRLDEEPKARGTLADLTCDSDGKIDQFIDLRDVKGVLELHPVRPEEPYYLGMFLNGAYQEILGDMHNLFGDTNTVHIHLASDEPGEQSYRLEHVVKGDTMTEVLKYVQYDHEAMLESIRRETEQALRERRITLSESRLLLQHYERSLSGYTYLTNELQVELAAR
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: YBEY_HAEI8
Sequence: MGSVLVDLQIATENIEGLPTEEQIVQWATGAVQPEGNEVEMTVRIVDEAESHELNLTYRGKDRPTNVLSFPFECPDEVELPLLGDLVICRQVVEREAAEQEKPLMAHWAHMVVHGCLHLLGYDHIEDDEAEEMESLETQIMQGLGFDDPYLAEK
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y777_CHLL2
Sequence: MVNEFDKLRPGKLLLASANLLESNFKRTVLLMCEHNEQGSMGFILNRPMEFKVCEAIAGFEDIEEPLHMGGPVQVDTVHFIHSRGDSIDGAIEIFDGVFWGGDKDQLSYLINTGVINPNEIRFFLGYSGWGAGQLEQEFEEGSWYTADATREMIFTDAYERMWSRSVRSKGGEYRIVANSPELPGLN
What are the official names of this protein?
UPF0301 protein Clim_0777.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.