PharMolix/UniProtQA huggingface dataset:
Protein: NMB_PIG
Sequence: MTLRARGARLLGGLLFFTLLAAGAAPLSWDLPEPRSRAGKIRVHPRGNLWATGHFMGKKSLEPPNPSLLGTTHHISLRDQRLQLSHDLLRILLQKKALGLSLSGPASHTPYRRLLVQTLEK
What is the function of this protein?
Stimulates smooth muscle contraction (PubMed:6882442).  Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).  Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity).  These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity).  Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity).  Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (PubMed:29632025).  Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity).  Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).
What are the official names of this protein?
Neuromedin-B.
What is the protein family that this protein belongs to?
Belongs to the bombesin/neuromedin-B/ranatensin family.
What are the subcellular locations of this protein?
Secreted. Cell projection, neuron projection. Note=In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex.
Protein: TRHO_SHEPW
Sequence: MSKVVVCAMYKFVSLPDFERIQKPLLIVMEKSGIKGTLLLAKEGINGTVAGSQSAIDALLAWLATQPGLDNIVHKLSFDDDMPFYRTKVKLKKEIVTMGVEGIDPNEVVGTYVKPKDWNALISDPEVLLVDTRNDYEVKIGTFENALDPQTATFREFPEYVKQNLDPTKHKKVAMFCTGGIRCEKSTAYLKEQGFEDVYHLEGGILKYLEEVKQEESMWQGECFVFDNRVAVNHDLEKGQYDQCNACRMPITEAEKASSQFEQGVSCPHCIDKVTDKQRERFLERERQVQLSKQRGEAHIGSDVSAVIESRRAKKEQLKKSQNEKSV
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: NADD_LISMO
Sequence: MKHKVGILGGTFDPPHLAHLHMAEEAKKQLELEKILFLPNKIPPHKHISGMASINERVEMLQLMIEGIDSFEIDTRELMRTGKSYTYDTMRDMIIEQPDTDFYFIIGGDMVEYLPKWYHIDDLVKMVTFVGVNRPLYQPEVPYDVVKIDMPKTTISSTEIRNDIEHAEAFLPEKVWSYIKEHQLYGKK
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: LSDA_DROME
Sequence: MKPTQFGGSSSKMTEPIEYVTLISDDSDGEPTPKRNVNHPPSALSAPNPGQKQKHPDEDSNDAPATSDERRTSRRNRPKVDYSNRPSGSGDTASNDKSGSASMGPNNQQAERRSQSQTRKSEANATSSSVSGPSAGNSRPSQNGDSKDRDAGTPTVLSGQEGAVFQSRLPFNKMTPNEEACFPDISRSGILGHRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPPFDSEPSLVRRVHSFLERHGFINFGIFKRLKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYSCVPVALTENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGEMFLFWSISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAEGLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYLGYPEGTPPDIGYSVAEAANLVSVGNVVKLRDLSPNLSDSSPSSKKSEENSNSNTADSTELQ
What is the function of this protein?
Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor.  Required for heterochromatic gene silencing.  Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.  Demethylates both mono- and tri-methylated 'Lys-4' of histone H3.  May also demethylate 'Lys-9' of histone H3, Plays a role in the repression of neuronal genes.
What are the official names of this protein?
Possible lysine-specific histone demethylase 1.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=In early cleavage, protein displays a uniform nuclear distribution. At metaphase, protein is detected at the chromosome periphery, and between the chromosomes during anaphase. A rather uniform interphase chromatin association is detected until syncytial blastoderm. When cellular blastoderm is formed (cycle 14), protein is preferably associated with pericentric heterochromatin situated at the apical pole of blastoderm nuclei. Later in development, protein is only found over euchromatin. In the germline precursor pole cells, protein remains uniformly distributed within the nucleus.
Protein: NQRE_TOLAT
Sequence: MEHYLSLFVKSIFIENLALSFFLGMCTFLAVSKKVKTAMGLGIAVVVVQAIAVPANNLVFTYVLKENALVQGMDLTFLGFITYIGVIAALVQILEMFLDRYVPSLYSALGIFLPLITVNCAIFGGVSFMVQREYNFPESVVYGVGSGISWALAIVLMAAIREKMKYSDVPPGLRGLGITFITAGLMALGFMSFSGISL
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit E, Na(+)-NQR subunit E, Na(+)-translocating NQR subunit E, NQR complex subunit E, NQR-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS3_SACEN
Sequence: MGQKINPHGFRLGITTDWKSRWYADKQYSEYVAEDVKIRRRLSRGMERAGISKVEIERTRERVRVDIHTARPGIVIGRRGAEADRIRGSLEKLTGKQVQLNILEVKNAEADAQLVAQGVAEQLSNRVSFRRAMRKAIQSAMRSPQVKGIRVQCGGRLGGAEMSRSEFYREGRVPLHTLRADIDYGFFEARTTFGRIGVKVWIYKGELVGGLKQKQQESEVRPPRGERGERGGRPERGGRRRSGASGTTGSGGTEAGRAAADKSKGSAQSPEQAQTSGDVASANAPQVAEPRADEKTEG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: DSBB_BURPS
Sequence: MNNLTLSLRRERRLLVLLALVCLALLAGALYLQYVKNEDPCPLCIIQRYFFVLIAVFAFIGAGMASGAGVAVTEALIVLSAAAGVGTAARHLYVQLNPGFSCGFDALQPVVDSLPPARWLPGVFKVAGLCETVYPPIFGILLPGWALIAFVLIAVPVAVSLLRHRGRLR
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TBA2_HOMAM
Sequence: MRECISIHVGQAGVQMGNSCWELYCLEHGIQPDGQMPSDKTVGVCNDSFNTFFTETGSGKHVPRAVFVDLEPSVIDEVRSGIYRQLFHPEQLISGKEDAANNYARGHYTIGKEYVDIVLDRIRKLADQCTGLQGFLIFRSFGGGTGSGFASLLMERLSVEYGKKSKLEIAIYPAPQSATSVVEPYNSILTTHTTLEHSDCCFMVDNEAIFDICQRNLDVSRPTYTNLNRLIGQIVSSITASLRFEGALNVDLTEFQTNLVPYPRIHFPLTTYSPIISAEKAYHEQLSVGEITSACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVTASIANVKTKRTIQFVDWCPTGFKVGINYQPPTVVPGADLAKVSRAVCMLSNTTAIAEAWARLDHKVDLMYAKRAFVHWYVGEGMEERQFSEAREDLATLEKDYEEVGIDTADGEDDEEANDY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-2 chain, Alpha-II tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: P2C50_ORYSJ
Sequence: MAAAAAAAAICGEDETAARVGCTGEWAGGIERVDLGERKEAVAAAGAGKRSVYLMDCAPVWGCASTRGRSAEMEDASAAVPRFADVPVRLLASRRDLDALGLDADALRLPAHLFGVFDGHGGAEVANYCRERIHVVLSEELKRLGKNLGEMGEVDMKEHWDDVFTKCFQRVDDEVSGRVTRVVNGGGEVRSEPVTAENVGSTAVVALVCSSHVVVANCGDSRIVLCRGKEPVALSIDHKPDRKDERARIEAQGGKVIQWNGYRVSGILAMSRSIGDRYLKPFVIPKPEVMVVPRAKDDDCLILASDGLWDVVSNEEACKVARRQILLWHKNNGAASPLSDEGEGSTDPAAQAAADYLMRLALKKGSEDNITVIVVDLKPRKKLKNIS
What is the function of this protein?
Protein phosphatase involved in abscisic acid (ABA) signaling.  Together with PYL3 and SAPK10, may form an ABA signaling module involved in stress response.
What are the official names of this protein?
Protein phosphatase 2C 50, OsPP2C50, ABI1-like protein 3, OsABI-LIKE3, OsABIL3.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: METK_ACIET
Sequence: MANDFLFTSESVSEGHPDKVADQISDAILDAIFTQDPRSRVAAETLTNTGLVVLAGEITTNAHVDYIQVARDTIKRIGYDNTEYGIDYKGCAVLVAYDKQSNDIAQGVDHASDDHLNTGAGDQGLMFGYACDETPELMPAPIYYAHRLVERQAQLRKDGRLPFLRPDAKSQVTMRYVDGKPHSIDTVVLSTQHSPDQSETATKMKASFTEAIIEEIIKPVLPKEWLQDTKYLINPTGRFVIGGPQGDCGLTGRKIIVDTYGGACPHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLARQCQIQVAYAIGVARPMNITVYTEGTGVIPDDQIAQLVQEHFDLRPKGIIQMLDLLRPIYAKTAAYGHFGREEPEFTWERTDKAAALRAAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG10_ALHV1
Sequence: MATVTAPMNMWSVRIVNGIFVLSNKKPLNLPAHLSQLNIPYSVHFIVDSLASFGLLSSLFSLDQVKQSCALLVQHKPNDQCTVLPTCVLDLEFDITVYVRSRQRVLQPGALQLALIFIKPVNGSEMAWDVRDPPETMVGQRLYENVSQGTVKALETPDHLLLTGEAIGRSDGTYDMLFKDQKIPCMVNYSNVFASYHSPNEEILPRALEITMLGQKTARLTFRPGHECPSATVSFRAEVRPILQPKVLFSHFLNWIRVNYDCQVMPLYPEQEEVVNAHDWVRFQVNNKFLVSTAVDTPLKVFICGLGQPSFLVADPGIWNPSSTCLLTLHNISNQPVKLRTCEPVAVGLLLYCNDAHLPSRDVCFCSETGRLEWRNCVVDSSQIFSWPHATQAKSLDSPKSMDS
What are the official names of this protein?
Uncharacterized gene 10 protein.
Protein: DEFB1_SAGOE
Sequence: MRTSYLLLFILCLVLCDMDSGDTFLTGLGHRSDHYNCVKGGGQCLYSACPIYTKVQGTCYGGKAKCCK
What is the function of this protein?
Has bactericidal activity.  May act as a ligand for C-C chemokine receptor CCR6.  Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner.  Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
What are the official names of this protein?
Beta-defensin 1, BD-1, Defensin, beta 1.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles.
Protein: PHLP1_DICDI
Sequence: MEQNILNSILDKFGDGDQERSDIRHNDSGDENDNHSDHEGNHGNNECCEGNEDGDKEYEVDVEDMTDEQYAQFIQEQQEPKIKSGGNTGVKGVLSDYAEHREKQKQKYLQKKYETQKMLEKMCFTTRDQPPPTEEENQLDSDDDDLERIRKARMEQWKSKQQITSDVKKPEKKVFGYFKQIDSSQYIHEIDNEPPNVFVIIHLFQNYIPECVLLNQQLGQLAVKYRYIKFLKILSKEAKENYHDEALPSLLVYIGGKLLVSFVPLTEELGRNFDQEDLELLLSSYDIIPNPMKAKNSNWETSLSRKRPESDDDNDD
What is the function of this protein?
Required for normal chemotaxis in response to cAMP and folate.  Required for the heterodimerization of the G protein beta and gamma subunits gpbA and gpgA, which is itself thought to be necessary for prenylation of the gamma subunit gpgA and its association with plasma membranes.
What are the official names of this protein?
Phosducin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the phosducin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAMA_ECOK1
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFEDVRVLRDGDTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTIADIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAEIQQINIVGNHAFTTDELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYVTVNITEGDQYKLSGVEVSGNLAGHSAEIEQLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSMPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDAVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYAVGINGTKNDYQTYAELSVTNPYFTVDGVSLGGRLFYNDFQADDADLSDYTNKSYGTDVTLGFPINEYNSLRAGLGYVHNSLSNMQPQVAMWRYLYSMGEHPSTSDQDNSFKTDDFTFNYGWTYNKLDRGYFPTDGSRVNLTGKVTIPGSDNEYYKVTLDTATYVPIDDDHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYFPHQARNYDPDYDYECATQDGAKDLCKSDDAVGGNAMAVASLEFITPTPFISDKYANSVRTSFFWDMGTVWDTNWDSSQYSGYPDYSDPSNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: EFPL_XYLF2
Sequence: MKASEMKKGSIVEYSNGTYQIRDIQRSSPQGRGGNVRFRFVMYSVPGGSKLEASFDADEMLTAVELLRREASFSYKDGEAFVFLDEEDYTLYTLDAEAIGDNAGYISEGLSGCYVQLIDASPVALQLPQHVVLEVVDTPPELKGGTATKRPKPAKLITGIEVMVPEYITTGERILVNTTTGAFGGRAS
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: RNPH_AZOSB
Sequence: MRPSQRQANELRPVRLTRRYTRHAEGSVLVEFGDTRVLCTASVEEAVPPFLKGKGRGWVTAEYGMLPRATHTRSAREAAKGKQTGRTQEIQRLIGRSLRAVVDLAALGERQVVIDCDVLQADGGTRTASITGAYVALHDALEGLVAAGKLAANPMTDFVAAISVGIVDGVPVLDLDYTEDSGCDTDMNVVMTGSGGIIEVQGTAEGTPFSRTELNALIDLAEAGIGRLVELQKAALAGA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: UGPA_ECO57
Sequence: MSSSRPVFRSRWLPYLLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGFSSRFVGLDNFVALFHDSYYIDSFWTTIKFSTFVTVSGLLVSLFFAALVEYIVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYDWNHAQNSGQAMFLVVFASVWKQISYNFLFFYAALQSIPRSLIEAAAIDGAGPIRRFFKIALPLIAPVSFFLLVVNLVYAFFDTFPVIDAATSGGPVQATTTLIYKIYREGFTGLDLASSAAQSVVLMFLVIVLTVMQFRYVESKVRYQ
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpA.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEA_MARMM
Sequence: MRVSDFDFHLPEARIALRPARPRDAARMLHVASNGVFADRGVRDLPDLLQPGDLMVFNDTRVIPAALKGIRPARAVGGGGPVEVEVNLHKRIDASAWRAFVRPAKRLRMGDEIAFGETLKAEVTGKSEGGDVRLVFNAAGAALDAAIAVAGEMPLPPYIARKRGVDEKDEADYQTLFATHEGSVAAPTAGLHFTPELMAALEARGVEQTRVTLHVGAGTFLPVKSDDTDDHQMHSEWCTVSAEAADAINAAKAEGRRVIPVGTTALRTIESLASGPGIVRAGSRDTDIFLTPGSDFAITDMLMTNFHLPKSTLFMLVSALSGLDVMQRAYAHAIAAEYRFYSYGDACLLERRT
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOI2_CERS4
Sequence: MKGILDSILRVGRMIFAPTKTVQYPEEKLPLAPRTRGRIVLTRDPDGQERCVACNLCAAACPVDCIDVVKAETPDGRWYPESFRINFARCIFCGYCEEACPTSAIQLTPDVELADYRRGFLQYEKEDLLISGEGKHPGYRYWDVAGKAIAGKAQDPVDPKDLCP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I 2, NADH dehydrogenase I subunit I 2, NDH-1 subunit I 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y3922_PSEAE
Sequence: MKTTKILLHTGVLALSLLATQVMAAVSADEAAKLGTSLTPLGAEKAGNADGSIPAWDGGLATNAGSVDSRGFLANPYASEQPLFTITAQNVDQYKDKLTPGQLAMFKRYPDTYKIPVYKTHRSATVPAAVQEAAKRNATTTKLVEGGNGLENFDTANPFPIPQNGLEVIWNHITRYRGGSVRRLVTQATPQVNGSYQLVYFQDAFTFRTNLKDYNPNKPSNVLFYFKQRVTAPSRLAGNVLLVHETLNQVKEPRLAWLYNAGQRRVRRAPQVSYDGPGTAADGLRTSDNFDMYNGAPDRYDWKLEGKKEIYIPYNSYKLDDPKIKYSEIVKAGHINQDLTRYELHRVWHVVATLKPGERHIYAKRDFYIDEDTWQAAEIDHYDGRGTLWRVAEAHAEQYYDKQVPWYAVETLYDLLSGRYLALGMKNEEKQAYDFNYSASESDYTPAALRQEGVR
What are the official names of this protein?
Uncharacterized protein PA3922.
Protein: HHLA3_HUMAN
Sequence: MFGACYKQPLKPSGSEPPAEECRMTPRHAGCDVTEMQRILSQPTFTEHLLRAVCTKLANMYSTSTDCREHCRRGMKAKQLKAEAGRSCQRKGVPIQTPREHSWISCKKEFEANP
What are the official names of this protein?
HERV-H LTR-associating protein 3, Human endogenous retrovirus-H long terminal repeat-associating protein 3.
Protein: ZCH18_MOUSE
Sequence: MDVAESPELDPHSPEDEEQPALSDDDILRESGSEQDLDGAGERASDLEEEENATRVQSQEETRSDEEDRASEPKSQDQDSEAHELSRGPAGSPCEEGDDVEEDGTSDLRDEASSVTRELDEHELDYDEEVPEEPAPAAQEEEAEKAGAEEEEEKGEGAPGEEGKPDVQSVGEQEPTEAAKEKKKEDDDGEIDDGEIDDDDLEEGEVKDPSDRKVRPRPTCRFFMKGNCTWGMSCRFIHPGVNDKGNYSLITKAEPFPPNGAPPLGPHPLMPANPWGGPVVDEILPPPPPEPPTESAWERGLRHAKEVLKKATIRKEQEPDFEEKRFTVTIGEDDREFDKENEVFRDWNSRVPRDVRDTTLEPYADPYYDYEIERFWRGGQYENFRVQYTEAEPYHNYRERERERERENRQRERERERERDRERERRQRERERERERERDKERQRRKEEWERERAKRDEKDRQHRDRDRDKDREKDKEKPKPRSPQPPSRQAEPPKKESTSVGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPPVRTKGEPAPPPGKAGEKSIKKPAPPPAPPQATKTTAPGPEPAKPGDLREARRKERQTRTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSVHSVDSDDMYADLASPVSSASSRSPTPAQTKKERGKSKKEDGVREEKRRRDPSAQPPKSSKAPAGGKASQQAAAPQPAVPGQPQQGSFVAHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPAKKANLSPDRGSRDRKSGGRMGSPKPERQRGQNAKAPAAPADRKRPLSPQSKGSSKVTSVPGKATDTATAGTKSGKASTLSRREELLKQLKAVEDAIARKRAKIPGKV
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 18, Nuclear protein NHN1.
What are the subcellular locations of this protein?
Nucleus.
Protein: URED2_BRUME
Sequence: MLGKARELANYQDEPEQLPTGSFGKNAFLRLGFERRPERTVLATLHRRAPLIVQQALYWDEGMPTLPCVSIISNAGGILQGDRYAIEIDLEPDTQAHVTTQSATRIQEMDANFATQTQTITLGANSYLEYIPHPIIPHKHSRFVQQTEVTIHPTATLIYSEVLMAGRKYYGTGELFHYDLFSSKFHAAHTDGTSLFTEKFIVEPARGNVSRLGAMGSFHVFGNLILLTPKTHADRLFETIDPVFDMDEGIAWGASRLPNDAGLLFKVLGMESAPVRAAIRKIWEAARQEVTGASLPENFLWA
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD 2.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUSD4_MOUSE
Sequence: MYHGMNPSNGDGFLEQQLQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLNVCADPGVPENGFRTPSGGVFFESSVTRFHCQDGFRLKGSTKRLCMKHFNGTLGWVPSDKPVCIQEDCRIPQIEDAEIRNKTYRHGEKLVIDCHEGFKIRYPDLYNLVSLCRDDGTWDNLPICQGCLRPLASSNGYVNISEFQTSFPVGTVIAYRCFPGFKLEGSENLECLHNLIWSSSPPRCLALEVCPLPPMVSHGDFICHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPTYDEAVNGSSSALGPGYPASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSTSGSSEMLQSLYSPPMCQGGSRPAPDTPDTISSTAGEVASTSPGIDIADEIPLMEEDP
What is the function of this protein?
Acts as complement inhibitor by disrupting the formation of the classical C3 convertase.  Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.
What are the official names of this protein?
Sushi domain-containing protein 4.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MTR_NEUCR
Sequence: MDSQYETKKNDPNAIMPYPESNDEHVGEVRGLGGGIMDKEPEAQEGHAKFHRLGWKRLTVVLIVEAIALGSLSLPGAFATLGMVPGVILSVGMGLICIYTAHVIGQTKLKHPEIAHYADVGRVMFGRWGYEIISFMFVLQLIFIVGSHVLTGTIMWGTITDNGNGTCSLVFGIVSAIILFLLAIPPSFAEVAILGYIDFVSICAAILITMIATGIRSSHQEGGLAAVPWSCWPKEDLSLAEGFIAVSNIVFAYSFAMCQFSFMDEMHTPSDYKKSIVALGLIEIFIYTVTGGVVYAFVGPEVQSPALLSAGPLLAKVAFGIALPVIFISGSINTVVVSRYLIERIWPNNVIRYVNTPAGWMVWLGFDFGITLIAWVIAEAIPFFSDLLAICSALFISGFSFYFPALMYFKITRNDAKSQGKKYFLDALNMLCFVIGMGILGIGTYAAIQDIMDRYDHGKVSKPYSCAPLA
What is the function of this protein?
Required for the transport of neutral aliphatic and aromatic amino acids via the N system.
What are the official names of this protein?
N amino acid transport system protein, Methyltryptophan resistance protein.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL31_HAEDU
Sequence: MKQGIHPEYKEITATCSCGNVIKTRSTVEKNLNLDVCGNCHPFYTGKQRVVDTGGRVERFNKRFNIPSTK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: TR140_SCHPO
Sequence: MDTTPDNSEKKKTSSVREATFSINESFGGRLLTEEEDVFEQNAWDHVEWDDEHLALAKKCIEEQKLYPVTEKDAYMTHPERYWDQFYGKNEGKFFMNRRWIAQEFPELLDLLKEDAGEKSILEIGCGAGNTIWPILKENKNSNLKIFAVDYSEKAIDVVKQNPLYDAKFCSASVWDLAGSDLLRSIEEASIDAITLIFCFSALSPDQWQQAIENLYRLLKPGGLILFRDYGRLDLTQLRAKKNRILSENFYIRGDGTRVYYMTNEELVDVFGKNFKIIQNGVDKRLIVNRKKRVKMYRCWLQAKFQK
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr) (PubMed:27354703).  Does not catalyze N(3)-methylcytidine modification of tRNA(Ser) (PubMed:27354703).
What are the official names of this protein?
tRNA N(3)-methylcytidine methyltransferase trm140.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METL family.