PharMolix/UniProtQA huggingface dataset:
Protein: GLMS_STAAR
Sequence: MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVTLQLISYYAALHRDLDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA_MYCTO
Sequence: MSFPYFISPEQAMRERSELARKGIARAKSVVALAYAGGVLFVAENPSRSLQKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKPPELYRITYDGSIADEPHFVVMGGTTEPIANALKESYAENASLTDALRIAVAALRAGSADTSGGDQPTLGVASLEVAVLDANRPRRAFRRITGSALQALLVDQESPQSDGESSG
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PrcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y331_LACP7
Sequence: MRFVIVTGMSGAGKSSVLKMLEDSSYFCVDNLPIPFIMKFARLAVKESANITKVALGIDIRSGQALEELGKVLEDVKSAGYQYEILFLEASTEILVKRYKETRRMHPLSGTGRVDKGIELERRKLRFLKERADYIIDTSRLLVRELKTEIDNIFVQDGTYRNFFITVLSFGFKYGLPNDADLVFDVRFLQNPYYVPKLKSKTGNEPEVRDFVLSLEQAEEFLTKLMDMLLFLIPNYIAEGKNQLVIGIGCTGGRHRSVTLANEITKRLSATEYGVKAEHRDVEKG
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Cphy_0331.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: MCA1_EMENI
Sequence: MHHHHQQPSYGSGYPGQAYRQQQNPYPQYGHPSPQPYPPQNGYSHPSSGYPPSPAPPNGGQMYHGRQPSYPPNQYPPAHGGPTAPPTNPQAFGHGAPQGYNFQYSRCTGKRKALLIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVILTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRVAGHIVDDEMHRIMVKPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVISSYARGDMGGMMSTAVGFLKKAAKGDEAYQRTKQTKTSPADVIMWSGSKDDQTSQDAQIAGQATGAMSWAFITAMRKNPQQSYVQLLNSIRDELSTRYTQKPQLSSSHPLDVNLLYVM
What is the function of this protein?
Involved in cell death (apoptosis).
What are the official names of this protein?
Metacaspase-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
Protein: D130A_HUMAN
Sequence: MKLHSLISVLLLFVTLIPKGKTGVIPGQKQCIALKGVCRDKLCSTLDDTIGICNEGKKCCRRWWILEPYPTPVPKGKSP
What is the function of this protein?
Antimicrobial host-defense peptide.  Has an antiplasmodial activity.
What are the official names of this protein?
Beta-defensin 130A, Beta-defensin 130, Beta-defensin 30, DEFB-30, Defensin, beta 130.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: C166A_DANRE
Sequence: MHSVICLFGAFIAAALFAPGSCLPTVIGLYGETIEVPCNNGNNKPDGLIFTKWKYAKDDGSPGDLLIKQAQKDDPTVSAMDGYKTRVSIAANSSLLIAQGSLTDQRVFTCMVVSSTNLEEFSVEVKVHKKPSAPVIKNKVKELENGKLTQLGECVVESANPAADLIWMKNNQALVDDGKTIIITSDVTKDPVTGLSSTSSRLQYTARKEDVASQFTCVAKHVTGPNQVSTPDTFQIRYPTEKVSLQVVSQSPIREGDDVTLKCQADGNPPPTSFNFNIKGKKVTVTDKDVYTLTGVTRADSGVYKCSLLDNDVMESTQIVTVSFLDASLTPTGKVLKKLGENLVVSLEKNASSEVKVTWTKDNRKLDKLPDFSQLRYSDAGLYVCDVSIEGIKHSFSFELTVEGGPRITGLTKHRSNDGKHKVLTCEAEGSPKPEVQWSVNGTDDETSYVNGKATYKLTVVPSKNLTVSCLVTNKLGFDTKDISVFSLFEEDKPKPGKNEDGADQAKVIVGVVVGLFLAAALVGLIYWLYIKKTRQGSWKTGEKETGTSEESKKLEENNHKADV
What is the function of this protein?
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts.  Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity).  Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity).  Mediates homotypic interactions with cells that express ALCAM.  Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction.  Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions.  Required for normal organization of the lymph vessel network.  Required for normal hematopoietic stem cell engraftment in the bone marrow.  Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow.  Promotes in vitro osteoblast proliferation and differentiation (By similarity).  Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity).  Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).
What are the official names of this protein?
CD166 antigen homolog A, Activated leukocyte cell adhesion molecule A, DM-GRASP homolog, Neurolin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse.
Protein: ATPA_BACCZ
Sequence: MSIRAEEISALIKQQIENYQSEIEVSDVGTVIQVGDGIARAHGLDNVMAGELVEFSNGVMGLAQNLEENNVGIIILGPYTEIREGDEVRRTGRIMQVPVGKELIGRVVNPLGQPVDGLGPINTTNTRPIESPAPGVMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTAVALDTIINQKDEDMICIYVAIGQKESTVRNVVETLRKHGALEYTIVVTASASQPAPLLYLAPYAGVTMGEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFIETQAGDVSAYIPTNVISITDGQIFLQSDLFFSGVRPAIDAGTSVSRVGGSAQIKAMSKVSGTLRLDLASYRELEAFAQFGSDLDKATQAKLNRGARTVEVLKQGLHKPLRVEKQVIILYALTRGFLDDIPVVDITRFEEEFHAWLDSNATDLLEEIRTTKKLADDDKFAAAINGFKKVFVASE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ALKMO_DANRE
Sequence: MAQVEANNVTVSQGFRMLFSLMTPEESSFATVEEVPKYVNQATPYFIGLILLEIVLGWLKTDGPHIKINDFITSLSAGMMSRLPQLMMRSVELSAYIYIWDNFHFLELPWDSAWTWWLAFLGVDMGYYWFHRFAHELNILWAGHQVHHSSEYYNLSTALRQSVTQQFSSWIFYSPLALLIPPSVFAVHIQFNLLYQFWIHTELVKDLGPLELILNTPSHHRVHHGRNPYCIDKNYAGILIIWDRMFGTFAPESDKVIYGLTHPIGTFEIWSVEFLYYPYLWQRFWEVEGISNKLSVIWKGPGWTPGKPRLGDIADIPQITGEEKPHDPAWSPVMQAYVILQFFLLLDVYNSLLLDQMILSELTVILLTAYVLLSLTSLGFLIDQRSNAAELEMLRCVLIMLLHRFGYIKPLLPALAFPMEAFILISTIYWSLQSVKQRTDKMKKQN
What is the function of this protein?
Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids.  Ether lipids are essential components of brain membranes (By similarity).
What are the official names of this protein?
Alkylglycerol monooxygenase, Transmembrane protein 195.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family. TMEM195 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LEPI_ASPFN
Sequence: METVAAIKTLIQQLAQSTDQFGRAEINDALRELQYSLETPFDTVMRMSLDTCQVAVARIGSDLGLFKHLSQCASPQSAEELADHLGCGRELMSRLLRYMASVRMVQQTDDIKYISSNITQTLAVPGLEAGMRHAFENLWPVLMALPDFLAERKYPDIVDAKDTAFQKAFNTDQDCFHWLATQPTRIANFKVLLTDERTPNFLSTFPLEKELGSWSAEPEKALFVDIGGGMGHACIRLREKYPNQPGRVILQDLPPVLQAAQATLPLSGIESMPHNFHTPQPVQGAKFYFLRLILRDFPDHQALEILQNIVPAMDAESRIVIDDGVPPEKGARWAETGTDICIMSALGSKERTQRQWEELAAKAGLQLQALYQYTWPVVNAAMVFSLQ
What is the function of this protein?
O-methyltransferase; part of the gene cluster 23 that mediates the biosynthesis of a family of 2-pyridones known as leporins (PubMed:20447271, PubMed:26051490).  The hybrid PKS-NRPS synthetase lepA and the enoyl reductase lepG are responsible for fusion of phenylalanine with a hexaketide and subsequent release of the stable tetramic acid precursor, pre-leporin C (PubMed:26051490).  Because lepA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase lepG (PubMed:26051490).  It is possible that the dehydrogenase lepF also participates in production of pre-leporin C (PubMed:26051490).  Cytochrome P450 monooxygenase lepH is then required for the ring expansion step to yield leporin C (PubMed:26051490).  Leporin C is then presumably further oxidized by the N-hydroxylase lepD to form leporin B (PubMed:26051490).  LepI may possess a function in biosynthesis upstream of lepA (PubMed:26051490).  Leporin B is further oxidized in the presence of ferric ion to give the leporin B trimer-iron chelate, but whether or not this reaction is catalyzed by an enzyme in the pathway or by ferric ion is not determined yet (PubMed:26051490).
What are the official names of this protein?
O-methyltransferase lepI, Leporins biosynthesis protein I.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: PLSX_BACC2
Sequence: MKIAIDAMGGDHAPKAVVLGAMKAIKEYSDLHITLVGKEEEIRQYLTSDERITILHTDEKIESTEEPVRAVRRKKQASMVLAAQQVKDGEADACISAGSTGALMAAGLFVVGRMEGIERPALSPTMPTVDGKGFVMLDVGANVDAKPIHLYQYAVMGSVYAEKVRGIENPRVGLLNVGTEDGKGNELSKQVFAMLKDAPINFVGNVESRDLLQGVADVVVCDGFTGNVALKSLEGTALALFSMLKEQLMSSFTSKLAAAVLKPKLMVLKDKMDYSEYGGAALFGLKAPVIKAHGSSNDQSIFSAIRQTREMVAKEVIPTISSVMEKESLQ
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: HACL1_RAT
Sequence: MSESNSAEGSDRSEEQVSGAKVIAQALKTQDVEYMFGVVGIPVTEIALAAQELGIKYIGMRNEQAACYAASAVGYLTGRPGVCLVVSGPGLIHALGGMANANMNCWPLIVIGGSSERNQEAMGAFQEFPQVEACRLYSKFSARPSSIQHIPFVIEKAVRSSIYGRPGACYIDVPADLVTLQESTTSIKYKECCMPPPLSLAETSAVRAAASVLRSAKQPLLIIGKGAAYSHAEDSIRKLVELCNLPFLPTPMGKGVVPDNHPNCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQADVKFIQIDICAEELGNNVRPSVTLLGDVNAVSKQLLEQFVKNPWQYPTDSKWWETLREKRKNNEAVSKELASKKSLPMNYYTVFYHVQEQLPRNCFIVSEGANTMDIGRTVLQNYLPRHRLDAGSFGTMGVGLGFAIAAAVVAKERSPGQRVICVEGDSAFGFSGMEVETICRYNLPIIILVVNNNGIYQGFDADTWGKILNFQGTATTIPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQDSLRQALKDTSKPCLINIMIEPQSTRKAQDFHWLTRSNI
What is the function of this protein?
Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner.  Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid (PubMed:10468558).  Involved also in the shortening of 2-hydroxy long-chain fatty acids (By similarity).  Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity).
What are the official names of this protein?
2-hydroxyacyl-CoA lyase 1, 2-hydroxyphytanoyl-CoA lyase, 2-HPCL, Phytanoyl-CoA 2-hydroxylase 2.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: PHLA2_DANRE
Sequence: MTGSDISHILKEGELEKRSDNLLQFWKRKTCVLTTDSLNIYTDQQKKNKSKELKLQSIKKVDCVEHTGKFVYFTIVTTDNKEIDFRCSDEKNCWNAVIAIALVNFQNRKAIQGFKTQKESENTSLGQQERCMARAP
What is the function of this protein?
Plays a role in regulating placenta growth.  May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).
What are the official names of this protein?
Pleckstrin homology-like domain family A member 2, Imprinted in placenta and liver protein.
What is the protein family that this protein belongs to?
Belongs to the PHLDA2 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: TYDC4_PETCR
Sequence: MGSIDNLMAQKLTSQFPMNTLEPEEFRRQGHLMIDFLADYYRKVENYPVRSQVSPGYLREILPESAPYNPESLETILQDVQTKIIPGITHWQSPNFFAYFPSSGSTAGFLGEMLSTGFNVVGFNWMVSPAATELENVVTDWFGKMLQLPKSFLFSGGGGGVLQGTTCEAILCTLVAARDKNLRQHGMDNIGKLVVYCSDQTHSALQKAAKIAGIDPKNFRAIETTKSSNFKLCPKRLESAILYDLQNGLIPLYLCATVGTTSSTTVDPLPALTEVAKKYDLWVHVDAAYAGSACICPEFRQYLDGVENADSFSLNAHKWFLTTLDCCCLWVRDPSALIKSLSTYPEFLKNNASETNKVVDYKDWQIMLSRRFRALKLWFVLRSYGVGQLREFIRGHVGMAKYFEGLVGLDKRFEVVAPRLFSMVCFRIKPSAMIGKNDEDEVNEINRKLLESVNDSGRIYVSHTVLGGIYVIRFAIGGTLTDINHVSAAWKVLQDHADALLDEAFTAN
What are the official names of this protein?
Tyrosine decarboxylase 4.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: CADH1_HUMAN
Sequence: MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD
What is the function of this protein?
(Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.
What are the official names of this protein?
Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Protein: PETG_PROM1
Sequence: MIEPLLCGIVLGLVPVTLLGLFVSAWNQYRRSSSMPDWE
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: CC074_HUMAN
Sequence: MQSVDSMLGTVGGCGGGEAASTFSKDPSGCCVGNDCRDGGRGLERRHGRWSRGEGGESGLCSGGQMASEIEYWDGLAISVMEVEKAFGSTNVLWKTEPFSLWACTAACPPSLSPTLLALGLPRDGKELAEQGSLWTVLEPGGDWSHSQSQLGTPGRGKGALGF
What are the official names of this protein?
Putative uncharacterized protein encoded by LINC00696.
Protein: ITM2A_HUMAN
Sequence: MVKIAFNTPTAVQKEEARQDVEALLSRTVRTQILTGKELRVATQEKEGSSGRCMLTLLGLSFILAGLIVGGACIYKYFMPKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTEEADIREDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVMPPKNLVELFGKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRDLLLGFNKRAIDKCWKIRHFPNEFIVETKICQE
What are the official names of this protein?
Integral membrane protein 2A, Protein E25.
What is the protein family that this protein belongs to?
Belongs to the ITM2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RLME_RICAE
Sequence: MTNNLSGYRNKFVRVKTSKKRTVSSSNWLRRQLNDPYVAKARMDGFRSRAAYKLLEIHEKFKLFTPNMKIVDLGAAPGGWSQVASKLIKASDNNLNNKIISIDVLEIEHVAGVEFVQKDFFEADTEELIIQALDGRADIVMSDMASNTIGHKATDHIRTLLLCEQAFEFALKVLKPSGHFIAKIFRGGAENELLYKVKREFKTVKHFKPSSSRSESTEIYLVALNKK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_ENT38
Sequence: MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: Y005_NPVOP
Sequence: MNRPTMRNTAAVTTDYDREQLRRELNSLRRSVHELCTRSATGFDCNRFLEAGDRAPAVIVKAAANGGQHSSLICDKV
What are the official names of this protein?
Uncharacterized 8.6 kDa protein, ORF7.
Protein: COAD_XYLFM
Sequence: MSVVNRRIAVYPGTFDPITNGHIDLVSRAAPLFESIVVGVAQSPSKGPSLPLQQRVTLAREALCQHENVQVIGFDTLLAHFVRHVGAGVLLRGLRAVSDFEYEFQMASMNRHLIPEVETLFLTPAEQHSFISSSLVREIARLGGDVSGFAPAAVVAALRQNL
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PARE_ENTFA
Sequence: MAKKINNEYNDASIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNAVDEALSGYGNEINVTIQKDNSICVADSGRGMPTGMHASGIPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSKWLEVHIVRDGVEYMERFEDGGKPVGTLKKIGKTKKRNGTSVTFLPDDTIFSTTNFSYEILAERLRESAFLLKGVKITLTDERGEEPKEEVFHYEEGIKEFVAYLNEEKDTLTPVVYFSGAKEGIEVELAYQYNDGYSENVLSFVNNVRTKDGGTHEVGMKTSMTKAYNEYARKVGLLKEKDKNLEGSDFREGLAAVLSIRVPENLLQFEGQTKGKLGTPLARTVVDNVVGEQMGFYLQENSEMSQSLIRKAIKAREAREAARKAREESRNGKKRKKGESLLSGKLTPAQSRNPKKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTIGAGVGPEFSIEDCNYDKIIIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVYIALPPLYKVSKGTGKKSVIEYAWTDGELAEVIDKVGKGYMLQRYKGLGEMNAEQLWETTMDPETRTLIRVRIDDAAQAERRVTTLMGDKVEPRRKWIEQHVQFTLEEDGSILDRSEEDTSAPTGESLLDAEKTKEAEQTDDTEISLFDIE
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA (PubMed:23352267).  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit B, Topoisomerase IV subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Protein: MKRN2_TAKRU
Sequence: MTTKQVTCRYFLHGVCREGNHCQFSHDPSSSKPSTICKFYQRGTCAYGERCRYDHVKLSSRGGGAFDMAGVGGARDGASTRGAAKKTFVHQERENMFRAPAESFGADVMAPAPHTYVDAIRTGLSSSSQDHTPPTMAGVNQDLPRLCPYAAVGHCYYEENCIYLHGDKCEVCGLQVLDPHNPEQRSMHEKMCLLAFEADMEKAFAVQLSQEKVCSICMEVVVQKMNPSDRRFGILSSCCHVFCLACIRKWRCTRNFSNKIIKSCPECRVASEFVIPSVYWEENQEDKVHLIELFKSGVGKKPCKYFDQGRGSCPFGGKCLYLHALPDGSRAEPEQPRKQLGSEGNIRFMNSVRLWDFIEEREQHSAPPLQAFADDISELRELFVQMSGPSPDEGESQSRSAP
What is the function of this protein?
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity).  Inhibits neurogenesis and axis formation during embryonic development by modulating the phosphatidylinositol 3-kinase (PI3K) pathway.  Acts downstream of PI3K and akt1 to up-regulate gsk3b mRNA expression.
What are the official names of this protein?
E3 ubiquitin-protein ligase makorin-2, RING-type E3 ubiquitin transferase makorin-2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRXB_BUCAI
Sequence: MDKVKHSKIIILGSGPAGYTAAIYAARANLDPFLITGTNKGGQLMNTNEIENWPGDYNKISGSELMNRMYKHAIELKTKVICDTVISVNFKKNPFFLIGENNKYTADSVIIATGANPRYLGLQSESLFKGKGVSTCAVCDGFFYKNKEVAVVGGGNTAIEETLYLSNFVKKVHLIHRGINFRAEKILLDRLEKKIKSQKIIIYLNSIVKNILGNSSGVTALLIEQKNSKEKTESKIQVSGLFVAIGYTPNTNIFVNKLKMKDGYIQVTRQEHGNYTQTSIPGIFAAGDVIDHVYRQAITSSASGCMAALDSERYINSLV
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METN_CORGL
Sequence: MSHTASTPTPEEYSAQQPSTQGTRVEFRGITKVFSNNKSAKTTALDNVTLTVEPGEVIGIIGYSGAGKSTLVRLINGLDSPTSGSLLLNGTDIVGMPESKLRKLRSNIGMIFQQFNLFQSRTAAGNVEYPLEVAKMDKAARKARVQEMLEFVGLGDKGKNYPEQLSGGQKQRVGIARALATNPTLLLADEATSALDPETTHEVLELLRKVNRELGITIVVITHEMEVVRSIADKVAVMESGKVVEYGSVYEVFSNPQTQVAQKFVATALRNTPDQVESEDLLSHEGRLFTIDLTETSGFFAATARAAEQGAFVNIVHGGVTTLQRQSFGKMTVRLTGNTAAIEEFYQTLTKTTTIKEITR
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TUSE_SHISS
Sequence: MLIFEGKEIETDTEGYLKESSQWSEPLAVVIAENEGISLSPEHWEVVRFVRDFYLEFNTSPAIRMLVKAMANKFGEEKGNSRYLYRLFPKGPAKQATKIAGLPKPVKCI
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Could accept sulfur from TusD (By similarity).
What are the official names of this protein?
Sulfurtransferase TusE, tRNA 2-thiouridine synthesizing protein E.
What is the protein family that this protein belongs to?
Belongs to the DsrC/TusE family.
What are the subcellular locations of this protein?
Cytoplasm.