PharMolix/UniProtQA huggingface dataset:
Protein: UTP10_DEBHA
Sequence: MSSLSQQLKSINEKTASVALDRKSRSKIHSKSLIFDPKIASTQDYDYLYQIGLEGLEDLIEIDSRFSKFKQTLFSETTINLDRNVQTQDTLDQLNKNVEVFLSLVSPYYLLTPSTKAVEWLIRRFYINIHNGEMLLLTSLPFYNSPVFVKILNVIPKNQFPKIFEWVVGYKDLLKSPTSSSILKSFHNDAKFFELYSKYLMDQLNNHAVFKEQLVFYLANTVQLVASFTHNLGQFGETYLPVILEVVGKLLLAGSKFSSTLRNDIMLTAYSIISVLSSLVPLSADLVKSFTESILQDPTACDSNTRKQTVIVLGQLWNFYNEDNFEVDCFKNLPASKLVQDDLLKNLIEEGYKINKLLVVYFASNLPQIDAFKIFDFINVDKSETFFKIVTSKLLYYAYNNQDEAIRAKLIEAFESLLRTNKELFVKVLQNYKDGLDISQLEMQLMTTLGDSNIENIHDADIELEDEEEEEEEDQAVLDVDFSDVCNSLENYKTSTTSFLNKSSDEEFTKLFQAFAEKSRSFNIKSQKLILAKFSKAIFVSPEASISFMLRVSFTPSVPLSIRLLVLRFIKLRLKELSLSEDKIDTYLLAPILLLGLYDTNKSVRAGFAELLRVVKDTTSKFHGNKKKVKTSLFMEDQIYGNTEPSKRAIVPPQDGLEMLNVLIEDSKSILDDTVIDKSRLNYVLFQVLFKSQKSGQKKFGQLLLKTFILNQWTLPFWPIVFKYKVWNIISIENNSNGGNDDRFFFIDTDLTDYFSNRDDLIEQAKASKIDFENDVEKAIVGLVGGTSSNDKNVNKEADWLLKALEAPNKLQVAAGKRLSSVFTSFTSIDMRAKLVNKLIELLINDGDDSDNLVVDPVEVLQLLDMDHETIISVLRNVQIVSQIPEQGIVKRRRRSSNSTKQAMARDDISSIAATHLKKLTIVLDLLEFNLRKKTSDIAKPDLLQNLFRILTDLDYLGNDGNLPILYAQETLASCMLLSIVQMKDNSKSNSFKFDSNVVRADLIVNSIRLSQSPQVQNRLLLVIAELAALAPEIILHSVMPIFTFMGAHTVRQDDEFSSSALQQTIAKVIPALAANGSSSLSYEIEFLLTSFVAAFQHIPRHRRVKLFTSLTKTLSYKHSLHIILFLMGQQYSNNITRNKAHESISILEFTSAFLKNFSAQEQLEGVEKFYQLWNQIPNAQLEPNSDEFNALSSRSIFGVSILSLSKSGLLTFKSQLLNFIDKVLDSDTQNDFSNLPSLKLKIALILLDPKKPAEDKSDLLNYFRKVTSFILSSLDTFTNVSRNDVLLDNLYALLGNFLDLLPLNYFIDSIIDSLDCDQISNTLEIKIAKNFAILASRKIENELNANNIDDVIEESILQKLLPVLNKGIKKNLDIELQQAYLNAFSSIVNKFGGSTHLLVTQGNTEALINSLNIITSNSGLLSEQPEIVISSINAITSIVNVLGVKAIGLFPKIVPPSLNIWKTTTASEDESSKLLQASIILLLACLIKKIPVFMTTSLDSIFITILTSDSVDNTVRSSVLQLIVEHMELSQVLKSLCNIWNNKKFYQNDNAGNLGLYLNVLQSTIERMDKKSASSQSTLFMKWLIQAFEFRHYAFDENNKFDNNTIHRLESSFHSCGASYVMKLNDKSFRPLFANLVRWAVSGEGSNATGNTELSRLLAFFKFFSKLQDKLKSIITSYFSYLIDPVSSILNRFANGDIVDINLRRILLNSLTSSFKYDQDDYWSQQSRFDSICSPLLNQLSNIEPNIGKYLVKCVSSFISNVSSEEYNEKLVHGLIEFISNENESTTSNTKIWTIRTLKTIFQKMGEQWLSYLPTLIPYIAELLEDDDEEVELEVRNGLVRVIENVLGEPLDRYLD
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA.  Involved in ribosome biosynthesis (By similarity).
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 10.
What is the protein family that this protein belongs to?
Belongs to the HEATR1/UTP10 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Membrane; Single-pass membrane protein.
Protein: RS20_PROA2
Sequence: MPLHKSAEKRLRQSARRNERNRARKKELKVLLKNVQKLIDTNADQGEVEAAYRSAVQKLDRLGVKRYIHPNKASRKKSQLSRMLNAYAQKD
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RL9_GEMAT
Sequence: MEVILRNAVDKLGHPGDIVSVSPGYARNFLIPRGFAYEATQGNRKRIAFEKSRLEALENERIAAAQAIADKLAEVSVTFAARVGEEGKLFGSVTTADIAHQLEAQGFKIEKRQIELNEPIKTLGVYRVGVRLHADVHPEIKVWVIKQ
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: PSPA_BACSU
Sequence: MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVKAETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLSELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVSSTSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAALKAKMMLDK
What are the official names of this protein?
Phage shock protein A homolog.
What is the protein family that this protein belongs to?
Belongs to the PspA/IM30 family.
Protein: SSRP_THEFY
Sequence: MARKKKQDKGQGPKTIAQNRRARHDYHIEDTYEAGLVLTGTEVKSLRAGRASLVDGFAQIKNGEVWLHNVHIPEYTMGTWTNHAPRRPRKLLLHREEIAKLDAKTREAGRTLVPLSLYFRNGRAKVEIALARGKREYDKRHDIAEREAKREMERALRRRR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: BXE_CLOBU
Sequence: MPTINSFNYNDPVNNRTILYIKPGGCQQFYKSFNIMKNIWIIPERNVIGTIPQDFLPPTSLKNGDSSYYDPNYLQSDQEKDKFLKIVTKIFNRINDNLSGRILLEELSKANPYLGNDNTPDGDFIINDASAVPIQFSNGSQSILLPNVIIMGAEPDLFETNSSNISLRNNYMPSNHGFGSIAIVTFSPEYSFRFKDNSMNEFIQDPALTLMHELIHSLHGLYGAKGITTKYTITQKQNPLITNIRGTNIEEFLTFGGTDLNIITSAQSNDIYTNLLADYKKIASKLSKVQVSNPLLNPYKDVFEAKYGLDKDASGIYSVNINKFNDIFKKLYSFTEFDLATKFQVKCRQTYIGQYKYFKLSNLLNDSIYNISEGYNINNLKVNFRGQNANLNPRIITPITGRGLVKKIIRFCKNIVSVKGIRKSICIEINNGELFFVASENSYNDDNINTPKEIDDTVTSNNNYENDLDQVILNFNSESAPGLSDEKLNLTIQNDAYIPKYDSNGTSDIEQHDVNELNVFFYLDAQKVPEGENNVNLTSSIDTALLEQPKIYTFFSSEFINNVNKPVQAALFVGWIQQVLVDFTTEANQKSTVDKIADISIVVPYIGLALNIGNEAQKGNFKDALELLGAGILLEFEPELLIPTILVFTIKSFLGSSDNKNKVIKAINNALKERDEKWKEVYSFIVSNWMTKINTQFNKRKEQMYQALQNQVNALKAIIESKYNSYTLEEKNELTNKYDIEQIENELNQKVSIAMNNIDRFLTESSISYLMKLINEVKINKLREYDENVKTYLLDYIIKHGSILGESQQELNSMVIDTLNNSIPFKLSSYTDDKILISYFNKFFKRIKSSSVLNMRYKNDKYVDTSGYDSNININGDVYKYPTNKNQFGIYNDKLSEVNISQNDYIIYDNKYKNFSISFWVRIPNYDNKIVNVNNEYTIINCMRDNNSGWKVSLNHNEIIWTLQDNSGINQKLAFNYGNANGISDYINKWIFVTITNDRLGDSKLYINGNLIDKKSILNLGNIHVSDNILFKIVNCSYTRYIGIRYFNIFDKELDETEIQTLYNNEPNANILKDFWGNYLLYDKEYYLLNVLKPNNFINRRTDSTLSINNIRSTILLANRLYSGIKVKIQRVNNSSTNDNLVRKNDQVYINFVASKTHLLPLYADTATTNKEKTIKISSSGNRFNQVVVMNSVGNCTMNFKNNNGNNIGLLGFKADTVVASTWYYTHMRDNTNSNGFFWNFISEEHGWQEK
What is the function of this protein?
Responsible for host epithelial cell transcytosis, host nerve cell targeting and translocation of light chain (LC) into host cytosol.  Composed of 3 subdomains; the translocation domain (TD), and N-terminus and C-terminus of the receptor-binding domain (RBD).  The RBD is responsible for the adherence of the toxin to the cell surface.  It simultaneously recognizes 2 coreceptors; host polysialated gangliosides and the receptor proteins SV2A and SV2B in close proximity on host synaptic vesicles.  Interaction with SV2 proteins requires SV2 glycosylation.  The N-terminus of the TD wraps an extended belt around the perimeter of the LC, protecting Zn(2+) in the active site; it may also prevent premature LC dissociation from the translocation channel and protect toxin prior to translocation (By similarity).  The TD inserts into synaptic vesicle membrane to allow translocation into the host cytosol (By similarity).  Binds ganglioside GD1a in vitro (PubMed:21849494).
What are the official names of this protein?
Botulinum neurotoxin type E, BoNT/E, Bontoxilysin-E.
What is the protein family that this protein belongs to?
Belongs to the peptidase M27 family.
What are the subcellular locations of this protein?
[Botulinum neurotoxin type E]: Secreted. SUBCELLULAR LOCATION: [Botulinum neurotoxin E light chain]: Secreted. Host cytoplasm, host cytosol. SUBCELLULAR LOCATION: [Botulinum neurotoxin E heavy chain]: Secreted. Host synapse, host presynaptic cell membrane. Host cytoplasmic vesicle, host secretory vesicle, host synaptic vesicle membrane; Multi-pass membrane protein.
Protein: VAT_CAMVE
Sequence: MRITGQPHVYKKDTIIRLKPLSLNSNNRSYVFSSSKGNIQNIINHLNNLNEIVGRSLLGIWKINSYFGLSKDPSESKSKNPSVFNTAKTIFKSGGVDYSSQLKEIKSLLEAQNTRIKNLEKAIQSLDNKIEPEPLTKKEVKELKESINSIKEGLKNIIG
What is the function of this protein?
This protein is involved in virus transmission.
What are the official names of this protein?
Aphid transmission protein, Atf, Protein 2.
What is the protein family that this protein belongs to?
Belongs to the caulimoviridae ORF II family.
Protein: CDCA3_RAT
Sequence: MGSTQSVSGTPARPLPRNKHVSRVADPRSPSAGIQRTPIQVESSPQPNPPAEQLNSLKQAQDPDPRSPTLGIARTPMKISGPDSQCPLVKELSEVFETEVSETEVSESISSPVLGLPQETPLSSELDLPPDPDPQVSLEDQLLPWSQTELNSKQVFAKEEAKQSTETMVSGQTSDKPSRDPETPQSSGSKRSRRKTNNKVLGRSPLTILQDDNSPGTLTLRQGKRPSALSENVKDLKEGVILGTGRFLKAGGGAWEQNEDHDKENQHFALMES
What is the function of this protein?
F-box-like protein which is required for entry into mitosis.  Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
What are the official names of this protein?
Cell division cycle-associated protein 3, Trigger of mitotic entry protein 1, TOME-1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RIMP_THET2
Sequence: MGVNPPFLCEGGGEVTVDLWQLVEEAVSPLGLDVLEVHFARGELLVRLERKDERPITVADLEEASRHIEAALDREDPIPGSYRLLVESPGPKRPLFTRRHFERFQGLKAKVPGPEGFTGRILRVEGEEVVFQVGDEERRLRIGTFRANLAEWPEEPR
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADC_BURM9
Sequence: MKPSQVRSKAFAMPLTSPAFPMGPYRFVNREFLIITYRTDMDRLREIVPEPLEVKEPLVHYEFIRMPDSTGFGDYTESGQVIPVEYKGQPGGYTLAMYLNDHPPIAGGRELWGFPKKLAQPTLQTHIDTLLGTLDYGPVRVATGTMGYKHQELDLEEQAKRLAGANFLLKIIPHVDGSARVCELVRYYLQDIEMKGAWTGPASLQLAPHALAPVADLPVLEIVEARHLLADLTLGLGEVVYDYLAQ
What is the function of this protein?
Catalyzes the conversion of acetoacetate to acetone and carbon dioxide.
What are the official names of this protein?
Acetoacetate decarboxylase, AAD, ADC.
What is the protein family that this protein belongs to?
Belongs to the ADC family.
Protein: PHS_IDILO
Sequence: MSNLENARCEACHADAPQVSDEELKELMREIPDWTPVTNDNVMMLQREFKFKNFKQALAFTNRVGDLAEEEKHHPELVTEWGKVTVTWWTHAINGLHKNDFIMAAKTDSVVDA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: CRCB_SACD2
Sequence: MTSAVPATSLILWLAVALGGALGALARYSVSIAWMPAQLKFPVATLTVNVLGSFLMGVFYVVIVEKAMLAPVWRHVIMIGFLGAFTTFSTFSIESLHLWQSGHWQIAISYVVANVVLSISAVVVAIVLTEKLV
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MAT2_EUGGR
Sequence: MYQSNLNLQKKVTSDLLYYSWLSLKCGWKYFFEIHNYCLFNSISRSWFKRTSSLIKKGFFIYPTVPLKIKNFFLSCTKKNFNLLKFKIVENAFLIIIKNFFIYKIYVQSMNLIECIFNVTSFSFMKPFFCKQCPNLLFSLTFFPFFKNDFLQKKKYFNSNKNFVKNFFSNEYFFSSSNSFFSIKFWDSQIKNFMTLKIIKLFDYVHKVRLKNIFSKFTYDSFFFVEIDKMFNLNLVNISSNLIYNSIENFGCSLLSSFFLNLYILEGDFFLDRFIFKICFKRNLFKTFFSFKKVSFFYQYSLKNFIPLRLEKNFFVSSFLKEVNSGKYHNIDIFYLFNNKVFTVYEKNIYYVRYLNFLIFGFLSSKNFIFFFKLKYLFFLRNKLYFNFREVQIFSSSNDKVIFLGVYIAYNKIYNFFEKLRVNKKYFLNVFQKIITKHNTFLKALKNIFHYSRCFNFFKKNCYPNFYKKKNFSFFNFYTESFRILKFFDAFFINTHHFFLPVELITSTKLVNFQKYTMYSFDFYNQKLSILLKDILENFNQFLSCSLVSIDLNLYNCLFEFKKHLVLLYNYYSPVYSFFSKRQRYKLNFNSFNYYSFSNFSGQNRSFFSSKANQFRFFKFFVPFKVFLKKLRLLGFIHPFKFRPIGNVRLLLFEDKFILRNFGFFVYSVLNWFSICENFSHLRFFVELIRESCFLTLCRKHNKMKLWSYSVYTFDLVFSKSVYRTISFFPTRKFIFNLKRKSFLVDVRFNLDETIFLE
What are the official names of this protein?
Maturase-like protein 2.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ASA1_LODEL
Sequence: MSSISSAPQQQFSLRYHKASISYILPISSRYIYSADQSGLVIKWDLQIRRPKLQWQAHKDSILTILQWHQYIVTHSRDSTIKVWLEDILQFEMPVNALNYTNIVLYRDNYLITPATLDSNNVDVYKLKQHPIEVSRVIANISIFELVNKTRTNMHANKAGDGVDINVKYADEFAIDDKDNMQGRQDFGIIMKMLVIDMTIYIGFESGDIVGLHLEVPESKLTRGSNSTLLINREPRLKLEYQNTLLVPNPVISLANLNGLLVSGSTGTKVVIHSDPTRTVKFHLSGIHSIQTYQDRLVIGFWDGAIEYKGEIIQRPLPQIKGGLDINSNGDDENEEENLKSNVKLTSMTLSSFGNSSGSDTAKVQHVRKPKYSEMVKAKSMSDALFAGYEDGTIMGYALI
What is the function of this protein?
Component of the ASTRA complex involved in chromatin remodeling.
What are the official names of this protein?
ASTRA-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ASA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1535_STRP6
Sequence: MTTEYIGEIVISPRVLEVITGIATTQVEGVHSLHNKKMADSFNKASLGKGVYLQTEEDGSVTADIYVYLQYGVKVPTVSMNIQKTVKSAVYDMAEVPISAVNIHVEGIVAEKTPKPDLKSLFDEDFLDD
What are the official names of this protein?
Uncharacterized protein Spy1535.
What is the protein family that this protein belongs to?
Belongs to the asp23 family.
Protein: RS14_SALDC
Sequence: MAKQSMKAREVKRVALADKYFAKRAELKAIISDVNATDEDRWNAVLKLQTLPRDSSPSRQRNRCRQTGRPHAFLRKFGLSRIKVREAAMRGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: ANSR_BACSU
Sequence: MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLEALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLITFIRTKRKVQEELS
What is the function of this protein?
Transcriptional repressor for the ans operon coding for L-asparaginase and L-aspartase.  NH4(+) may influence this repression.
What are the official names of this protein?
HTH-type transcriptional regulator AnsR, Ans operon repressor protein.
Protein: RL9_ECOSE
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNIEFFEARRAELEAKLAEVLAAANARAEKINALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTTGEHEVSFQVHSEVFAKVIVNVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: XYNB_ASPNG
Sequence: MLTKNLLLCFAAAKAALAVPHDSVAQRSDALHMLSERSTPSSTGENNGFYYSFWTDGGGDVTYTNGDAGAYTVEWSNVGNFVGGKGWNPGSAQDITYSGTFTPSGNGYLSVYGWTTDPLIEYYIVESYGDYNPGSGGTYKGTVTSDGSVYDIYTATRTNAASIQGTATFTQYWSVRQNKRVGGTVTTSNHFNAWAKLGMNLGTHNYQIVATEGYQSSGSSSITVQ
What is the function of this protein?
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
What are the official names of this protein?
Endo-1,4-beta-xylanase B, Xylanase B, 1,4-beta-D-xylan xylanohydrolase B, Endo-1,4-beta-xylanase G1, Xylanase G1, Endo-1,4-beta-xylanase II, Xylanase II.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 11 (cellulase G) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GST_PLAF7
Sequence: MGDNIVLYYFDARGKAELIRLIFAYLGIEYTDKRFGVNGDAFVEFKNFKKEKDTPFEQVPILQIGDLILAQSQAIVRYLSKKYNICGESELNEFYADMIFCGVQDIHYKFNNTNLFKQNETTFLNEDLPKWSGYFEKLLKKNHTNNNNDKYYFVGNNLTYADLAVFNLYDDIETKYPSSLKNFPLLKAHNEFISNLPNIKNYITNRKESVY
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin).
What are the official names of this protein?
Glutathione S-transferase, PfGST.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: IRS1_DROYA
Sequence: MASISDDGMALSGYLKKLKTMKKKFFVLYEETSHSAARLEYYDSEKKFLQRAEPKRVIYLKNCFNINRRLDTKHRFVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQRNIANSNGTAHSPYDQVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVASIEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAVATNMHNTILSAMSAKTESNTNLINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQNSQNSLEFRSCSSPHNYGFGRERCDSLPTRNGTLSESSNQTYFGSNHGLRSNTISGNRPHSTNKHSNSPTFTMPLRCSESEESSISVEESDDNGSYSHYRLNTRTSETAIPEENIDDFASAEFSKVTEPNESDENYIPMTPINPTDAIHEKEKIDMQRLEDASLHFDFPEHASEKLAKDYDLDSDNQCVRPIRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVRAYSVGSKSKIPRCDLQRVVLVEDNKHEFVANRSQSSITKEGSGYGTSGNRQKKSTSAPLLSLKNQINSDRMSDLMEIDFSQASNLEKQKFIKNNEIPKYIENVFPKTPRTDSSSLTLHATSQKDIFNGTKLNNTANTSEDGYLEMKPVGNAYTPSSNCLPIKVEKLKLSDYTAPLTTAAPVHDLNKISTYNISAEKWREQTTSEEKKSNSPLNEKPFSLKPTNVENISHDVHSTNNIDCEQVSVQSDKQNNLDDKIVENNNLDIGGHEEKKLVHSISSEDYTQIKDKSNDFTKFNEAGYKILQIKSDSSLISSKLYQKGIHKDNLERSHRLTESVNTIPDNATASSSVTKFNINAKAADSRSTDPSTPQNILQIKDLNFPSRSSSRISQPELHYASLDLPHCSGQNPAKYLKRGSRESPPVSACPEDGNTYAKIDFDQSDSSSSSSNIFNT
What is the function of this protein?
Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.  May mediate the control of various cellular processes by insulin-like peptides.  When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains.  Involved in control of cell proliferation, cell size, and body and organ growth throughout development.  Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions.  Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation (By similarity).
What are the official names of this protein?
Insulin receptor substrate 1, Protein chico.
Protein: CLD16_MOUSE
Sequence: MKDLLQYAACFLAIFSTGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSIYAEHPLKLVVTRALMITADILAGFGFITLLLGLDCVKFLPDDPQIKVRLCFVAGTTLLIAGTPGIIGSVWYAVDVYVERSSLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGALLTCCLYLFKDVGPERNYPYAMRKPYSTAGVSMAKSYKAPRTETAKMYAVDTRV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.  Involved in paracellular magnesium reabsorption.  Required for a selective paracellular conductance.  May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients.  Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity).
What are the official names of this protein?
Claudin-16, Paracellin-1.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: RL4_RICBR
Sequence: MKTKILNLANEEIGEISLNEDIFAVEFIRDDIIKQVVDWQRAKAMAGTHKTKTVSEVSGTTKKPFKQKGTGNARQGSLRSVQMRGGGVIHGPVVRSHATKLPKKVRKLGLIHALSEKFSEGKLLVIDSLKLETPKTSNLVNILNKFQGKSFFVIDGNEVDVNFSLAAQNIYNTVVVPQIGANVYDIIRHEYVLLSQEAVNVLEERLK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: DHE4_HAEIN
Sequence: MSKVASLDAFLTKVAQRDGYQPEFLQAVREVFTSIWPFLEANPKYRSEALLERLVEPERAFQFRVAWTDDKGQVQVNRAFRVQFNSAIGPFKGGMRFHPSVNLSILKFLGFEQIFKNALTTLPMGGAKGGSDFDPKGKSDAEVMRFCQALMAELYRHVGADTDVPAGDIGVGGREVGYLAGYMKKLSNQSACVFTGRGLSFGGSLIRPEATGYGLIYFAQAMLAEKGDSFAGKVVSVSGSGNVAQYAIEKALSLGAKVVTCSDSSGYVYDPNGFTTEKLAALFDIKNTKRGRVKDYAEQFGLQYFEGKRPWEVQVDIALPCATQNELELSDAQRLIKNGVKLVAEGANMPTTIEATEALLAADVLFGPGKAANAGGVATSGLEMAQSSQRLYWTAEEVDAQLHRIMLDIHANCKKYGTIEGQENINYVVGANVAGFVKVADAMLAQGVY
What is the function of this protein?
Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.
What are the official names of this protein?
NADP-specific glutamate dehydrogenase, NADP-GDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: CKS1_SCHPO
Sequence: MSKSGVPRLLTASERERLEPFIDQIHYSPRYADDEYEYRHVMLPKAMLKAIPTDYFNPETGTLRILQEEEWRGLGITQSLGWEMYEVHVPEPHILLFKREKDYQMKFSQQRGG
What is the function of this protein?
Binds to the catalytic subunit of the cyclin dependent kinase (cdc2) and is essential for its biological function.
What are the official names of this protein?
Cyclin-dependent kinases regulatory subunit, P13.
What is the protein family that this protein belongs to?
Belongs to the CKS family.
Protein: GCST_XANCP
Sequence: MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQIDEHHQVRRDAGMFDVSHMTVVDLHGVRVREFLRYLLANSVDKLKVSGKALYTCMLNPQGGVIDDLIVYFMQEEFFRLVVNAATRDKDLQWIGEQAARFEVRVKERADFAMIAVQGPNARSKVIDLLDPADASAASKLGRFAALQTRTRDGVALFLARTGYTGEDGFEIVLPQADAVAFWNALLAHGVAPAGLGARDTLRLEAGMNLYGQDMDDNVTPYEAALAWTITLDEGRDFIGRSVLESQKAQGAPRQMIGVVMDEKGVLRHGQKVLSAGGEGEILSGTFSPTLGKAIAFARVPAGSIDDLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: RBFA_ROSCS
Sequence: MSKRTEQLGHEIQRILGEILQYELKDPRVGFATVVGVEVTADLQIARVRISVMGTPEERKETMAALERAKGFLRRRLAEELNYLRFVPELRLILDTSVDYSLHIDELLRRAAAERAGSPPPQPEDDKPAE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_BACC2
Sequence: MPKQKTHRGAAKRFKKTGSGKLKRSHAYTSHLFANKSTKAKRKLRKAGVVSAGDFKRIRQMLDNLK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: PLA1A_RAT
Sequence: MCPGLWGTCFWLWGSLLWLSIGRSGNVPPTTQPKCTDFQSANLLRGTNLKVQFLLFTPSDPGCGQLVEEDSDIRNSEFNASLGTKLIIHGFRALGTKPSWINKFIRALLRAADANVIAVDWVYGSTGMYFSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGRITGLDPAGPEYTRASLEERLDSGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFIHAGYSYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVKIEPLPKEVRVYLQTTSSAPYCVHHSLVEFNLKEKRKKDTSIEVTFLGNNVTSSVKITIPKDHLEGRGIIAHQNPHCQINQVKLKFHISSRVWRKDRTPIVGTFCTAPLPVNDSKKTVCIPEPVRLQVSMAVLRDLKMACV
What is the function of this protein?
Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:8999922).  Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (PubMed:11395520).  Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (PubMed:8999922).
What are the official names of this protein?
Phospholipase A1 member A, Phosphatidylserine-specific phospholipase A1, PS-PLA1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.