PharMolix/UniProtQA huggingface dataset:
Protein: RSMG_FRAP2
Sequence: MDSMKDKIRQALVELDIQATEEQIEQWLEYLKLLEKWNKVYNMTAIKKIDDMLVKHLFDSLAVAKYIKGSSTVDVGTGGGLPGVVLAILYPQHQFTLVDSVGKKIMFLKNVKKSLGLDNINPLNIRIENLNGSFDNIISRAFSSVDTFYELCKHFLTKDNQMLAMKGPDLEEQNLVSLPLDIEKHSIKVPFLNAERNLIVMRKK
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_ASHGO
Sequence: MARTFFVGGNFKLNGSKQSIKEIVERLNTADLADNVEVVICPPATYLDHAVSLVSHPQVTVGAQNAYTKASGAYTGENSVDQIKDVGAKWVILGHSERRTYFNEDDEQVAEKTAFALERGVSVILCIGETLDEKKAGVTLDVVKRQLTPVLEKVKDWTNVVIAYEPVWAIGTGLAATAEDAQDIHAAIRDFLAERTSRDVADAVRILYGGSANGANAASFRDKADVDGFLVGGASLKPEFVDIINSRR
What are the official names of this protein?
Triosephosphate isomerase, TIM, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
Protein: SYDND_MAGMM
Sequence: MKRTHYCNDVRESQIGETVVLEGWINRRRDHGGVIFVDLRDRTGLVQVVFSPELFAEPHAQAHTLRSEYVIRATGKVTARSEGTINPNMDTGRIEVVVEDLTILNSSLPLPFQLDDEISENLRLQYRFLDLRRPDMQRNLMFRHRIMQSVRKHLDGSGFVEVETPMLTRSTPEGARDYLVPSRVNPGDFYALPQSPQLFKQLLMMAGYDRYFQIVRCFRDEDLRADRQPEFTQIDLEMSFVEPNDVMELTESVVVEAFKEALGVSIPQPVRRITYAEAMDKYGLDAPDMRITMELKDLTEVMKSSEFKVFRQAATLEGRGNEHGLVKVLKVPGGGSLTRKQIDTYTEFVGIYGAKGLAYIKVNGPWQEDGWQSPIVKFLGDAEKQAIQEATQAQVGDLLFFGADKASVVNESLGRLRVKLGKELEMLCDEKFAFVWVTDFPLLDWDNEARRNTAVHHPFTAPHPDDIIYLENADGASVEHPLEKVRSLAYDLVLNGTEVGGGSIRIHDTMLQRRMLELLEIGEEEAEGKFGFLLRALQYGAPPHGGLALGLDRLVTLMLGLDSIRDVIAFPKTQKATCLMTEAPSKVDGAQLKELHLRSTFKPKTAE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE1_ACTP7
Sequence: MALTIPRSQYVATYGPTVGDKVRLGDTDLWATIEQDFLTKGDECKFGGGKSVRDGMAQSSTATRDNPNVLDFALTNVMIIDAKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIGASTEVHNGAHLIATAGGIDTHIHWICPQQAQHAIENGITTMIGGGSGPADGTHATTCTPGKFNIERMFQACEALPVNIGFFGKGNCSMLEPLKEQVVAGALGLKIHEDWGATPAVIDAALKVADEMDVQVAIHTDTLNESGFLEDTMKAINGRVIHTFHTEGAGGGHAPDIIKAAMYPNVLPASTNPTRPFTVNTIDEHLDMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGVFSIMSSDSQAMGRVGEVVTRTWQTADKMKAQRGALGDEGNDNFRIKRYIAKYTINPAIAHGISQYVGSLEVGKLADIVLWKPQFFGVKPEFVMKKGFISFAKMGDPNASIPTPQPVFYRPMFGANAKANTESAVYFVSQASVDANIKAQYGIQKETLAVKGCRDVGKKDLVHNNATPEITVDPERYEVRVDGEHITCEPATKVPLAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHI2_CAPAA
Sequence: SAIWFWMTPQSPK
What is the function of this protein?
Defense against chitin-containing fungal pathogens.
What are the official names of this protein?
Endochitinase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
Protein: RNZ_LACP3
Sequence: MEIQFLGTGAGSPSKSRNVSSLALKLLDERNEVWLFDAGEGTQHQILQTAIRPRKIAKVFITHLHGDHIFGLPGFLASRSNQGGTDPLTIYGPSGIEDFVKTSLKVSQSHLSYPLKFVLLQHPGVAFEDQTFKVTFDRLDHRITSFGFRIEEKPHPGELLIDKVRAAKIPSGPVYAALKAGETVTLPDGRIFDGHDFIGPAQPGRTVAIFGDTRMCNRALPLAAGADVLVHESTFGPDESQLAKQYYHATNVQAAALAKRAGVGRLLLNHISARYLSPGVAMLEKTARQIFPNTHVVKDFEEINIPFRSEQSEPAVTVKS
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RL16_CALBD
Sequence: MLMPKRVKWRKQQRGRMKGKATRGNFVAYGDFGIMALEPGWITSNQIEAARVAIARHIKRGGKVWIKIFPDKPVTRKPAETRMGSGKGSPEYWVAVVKPGRVMFEVGGVDEEVAKEALRLAIHKLPIKCKIVSREEAKVGGEANEGV
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: DNM3L_RAT
Sequence: MGSRETPSSCSKTHETLNLETPESSSTDPDSPLEEQWPKSAPDLKEEDSMDMVLEDSKEPLTPSSPPTGREVIRYEVNVNQRNIEDICLCCGSLQVYAQHPLFEGGICAPCKDKFLETLFLYDEDGHQSYCTICCSGHTLFICESPDCTRCYCFECVDILVGPGTSERINAMACWVCFLCLPFSRSGLLQRRKKWRHQLKAFHDREGASPVEIYKTVSAWKRQPVRVLSLFGNIDKELKSLGFLESSSGSEGGTLKYVEDVTNVVRREVEKWGPFDLVYGSTQPLGYSCDRCPGWYMFQFHRILQYARPRQDSQQPFFWIFVDNLLLTEDDQETTVRFLQTEAVTLQDVRGRVLQNAMRVWSNIPGLKSKHADLTPKEEQSLQTQVRTRSKLAAQKVDSLVKYCLLPLREYFKYFSQNSLPL
What is the function of this protein?
Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context.  Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain.  Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (By similarity).  Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (By similarity).  Plays a key role in embryonic stem cells and germ cells.  In germ cells, required for the methylation of imprinted loci together with DNMT3A.  In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization.  Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation.  While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes.  Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes.  Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity).
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase 3-like.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURT_BURM9
Sequence: MQIGQRLGTPLSPSATRVMLLGAGELGKEVIIALQRLGVEVIAVDRYPNAPGHQVAHRAHVIDMTDPDALRALVDAERPHLVVPEIEAIATDALAAIEAAGVCEVIPTARATQLTMNREGIRRLAAEELGLPTSPYAFAQSFDEFAAAVARIGFPCVVKPVMSSSGKGQSVLRSEADIEPAWRYAMAGGRVNHGRVIVEGFIRFDYEITQLTVRAIDPASGQTRTSFCAPIGHLQVAGDYVESWQPQPMSAKALERSRDIAHRVTSALGGRGIFGVELFVRGDDVWFSEVSPRPHDTGLVTLASQRQSEFELHARAILGLPVEPALATPAASAVIYGGLDEAGIAFEGVRDALAVPGADLRLFGKPESFAKRRMGVALATGANVDEARERAKRAAAAVRPVSAR
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: ACCD6_MYCTO
Sequence: MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
What is the function of this protein?
Component of a biotin-dependent acyl-CoA carboxylase complex.  This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate.  When associated with the alpha3 subunit AccA3, is involved in the carboxylation of acetyl-CoA and propionyl-CoA.
What are the official names of this protein?
Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta6 subunit, Acetyl-CoA carboxylase, ACC, Propionyl-CoA carboxylase, PCC.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
Protein: RISB_CLOBL
Sequence: MKIYEGRLTAEGLKVGIIVSRFNEFITSKLLAGSIDCLKRHGAKEDNIEVCWVPGAFEIPVIAKKMASKGKYDAVICLGAVIRGATPHFDYVSSEVSKGVAHVSLDKEVPVIFGVLTTDTIEQAIERAGTKAGNKGYDAAMSAIEMSNLMKVLD
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: NTPPA_LEPIN
Sequence: MIVLRSKSPRRKQILESLDLDFRIESEDIDESSLKDEHPLEYLKRISLSKLGTRSKDELLISCDTIVVQENSILQKPENFSQAIEMLERLSGKTHIVYSGLGIYYNRLEQFAFDSSKVHFHTWNKEQIKKYIERYSPFDKAGSYGVQDIEGPVQSFEGSYTNILGFPIRMFFQYHELWKKYLKGNQA
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCTD_RHILE
Sequence: MDTLMPVALIDDDKDLRRATAQTLELAGFSVSAYDGAKAALADLPADFAGPVVTDIRMPEIDGLQLFATLQGMDVDLPVILMTGHGDIPMAVQAIQDGAYDFIAKPFAADRLVQSVRRASEKRRLVLENRMLRKAAEDAQENLPLIGQTPVMENLRNILRHIADTDVDVLVAGETGSGKEVVAQILHQWSHRRKGNFVALNCGALPETVIESELFGHERGAFTGAQKRRTGRIEHASGGTLFLDEIESMPAATQVKMLRVLEMREITPLGTNEVRPVNLRVVAAAKIDLGDPAVRGDFREDLYYRLNVVTISIPPLRERRDDIPLLFSHFAARAAERFRRDVPPLSPDVRRHLASHTWPGNVRELSHYAERVVLGVEGGGAAAVPPQPTGATLPERLERYEAEIIRDTLSANDGDVRRTIEALGIPRKTFYDKLQRHGINRGGYSSRK
What is the function of this protein?
Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates.  When activated by DctB acts in conjunction with sigma-54 to activate the transcription of dctA.
What are the official names of this protein?
C4-dicarboxylate transport transcriptional regulatory protein DctD.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_BURP6
Sequence: MAKTLSKSSGGALAPWLGISLIVILFDQLTKIAVLKTFAYGAMHALTPFFNLTLIYNRGAAFGFLATAGGWQRWAFTALGIGATLVICYLLKRHGHQRLFSLSLALILGGALGNVIDRLIYGHVIDFLDFHVGAWHWPAFNLADSAITVGAVLLIYDELRRVRGAR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYPC_BACSU
Sequence: MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVKERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSREREMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQSLHYSLARMPSLPESGFVMSGIRRKS
What is the function of this protein?
Catalyzes the alpha- and beta-hydroxylation of myristic acid in the presence of hydrogen peroxide.
What are the official names of this protein?
Fatty-acid peroxygenase, Cytochrome P450 152A1, Cytochrome P450BsBeta, Fatty acid beta-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: STHA_VIBC3
Sequence: MGQKNHFDVIVIGSGPGGEGAAMGLTKGGKNVAIIEKESSVGGGCTHWGTIPSKALRHAVSRIIEFNSNPLFCKNNSSIHATFSTILSHAKSVIDKQTRLRQGFYDRNQCTLIFGAAHFIDAHTVAVKKADGSIDTYSADKFVIATGSRPYHPKDVDFGHPRIYDSDSILNLEHDPRHIIIYGAGVIGCEYASIFRGLDVKTDLINTRDRLLSFLDNEVSDALSYHFWNSGVVIRNDETYDKVEGTSDGVIVHLKSGKKMRADCLLYANGRTGNTDKLNLESVGLQADSRGQLVVNANYQTQVEHIYAVGDVIGYPSLASAAYDQGRFVAQAIIHGQAAHLLTEDIPTGIYTIPEISSVGRTEQELTAAKVPYEVGRASFKHLARAQIAGKDIGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAFRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AA2BR_HUMAN
Sequence: MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
What are the official names of this protein?
Adenosine receptor A2b.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CBX4_HUMAN
Sequence: MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
What is the function of this protein?
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530).  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530).  Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity).  Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity).
What are the official names of this protein?
E3 SUMO-protein ligase CBX4, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235).
Protein: PDF2_CAEEL
Sequence: MSSRISVSLLLLAVVATMFFTANVVDATPRSQGNMMRYGNSLPAYAPHVLYRFYNSRQFAPINKRNNAEVVNHILKNFGALDRLGDVGK
What is the function of this protein?
Probable ligand of isoforms a and b of the calcitonin receptor-like protein, pdfr-1, a G-protein coupled receptor (PubMed:18390545).  May not signal through isoform c of pdfr-1 (PubMed:18390545).  Involved in locomotion; may play a role in circadian rhythms of locomotor activity (PubMed:18390545, PubMed:22579613, PubMed:26113231).  Modulator of egg-laying (PubMed:22579613).
What are the official names of this protein?
Pigment dispersing factor homolog pdf-2.
Protein: NGAP_HUMAN
Sequence: MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
What is the function of this protein?
Inhibitory regulator of the Ras-cyclic AMP pathway.
What are the official names of this protein?
Ras GTPase-activating protein nGAP, RAS protein activator-like 2.
Protein: DMRTA_MOUSE
Sequence: MERLPHGRRDRSGGCRPHLAPGRAAAPASAARSVSSGIPVSATFLRPPGLFLRSTASSGRAGCAPGPGLDRALGAVGCGYPRTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQVALRRQQAQEESEARGLHRLLYQGSSGSGAQASGGSGRTESPQVLNNPMAVAVLGAGASRHPGSRSVPTFEVFQQDYADRKQEPKQRNCESCQSRQEEPVSNTHHHSLGSSKGNVTVEKQGFMSSIPEHPDKSTIILSPCPTDQSGGEDSPRSFSSSDLESGNESEWARDYIATRASLSTVTSRPRDPLGILTRIFPGYKHSRLEGILQFCKGDVVQAIEQILNGREHKPDCRDLARADLENAAFQRASDFSLAGIGFGTLSNKSALSPLEAASAAYGGDSTLYSFNPRLAFSPLRLAYSSPGRALSGFVSPYLTPGLVPALPFRPTLDYAFPGMIREPSHLPSKHLVAGGRLYFRPNQEHL
What are the official names of this protein?
Doublesex- and mab-3-related transcription factor A1, Doublesex- and mab-3-related transcription factor 4.
What is the protein family that this protein belongs to?
Belongs to the DMRT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PQQE_ACIB5
Sequence: MTEGVGLPLWLLAELTYRCPLQCPYCSNPLDYAQHKNELTTQEWFDVFDQARQMGAVQLGFSGGEPLVRQDLEQLVAHAHQLGFYTNLITSGMGLTEQRISHLKQAGLDHIQISFQASDPVVNDALAGSKHAFEQKYEMCRLVKKYDYPMVLNFVIHRHNIDQIDKIIELCLELNADTVELAICQFYGWAFLNRQGLLPTQEQLIRAERITNEYREKLKAQNHPCKLIFVVPDYYEERPKACMNGWGKIFFTVAPDGMALPCHAARQLPISFPNVREQSLSRIWYESTGFNHFRGDAWMPEGCRSCPDKDRDFGGCRCQAYMLTGNASNADPVCGKSPYHQFIEQARAESEIDSSLEKLVFRNSRNSKQFTVQQNIPVQNIVDD
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.
Protein: PPDK_ENTH1
Sequence: MQRVYAFEDGDGTNKKLLGGKGAGLCTMTKIGLPVPQGFVITTEMCKQFIANGNKMPEGLMEEVKKNMQLVEKKSGKVFGGEENPLLVSVRSGAAMSMPGMMDTILNLGLNDKTVVALAKLTNNERFAYDSYRRFVSLFGKIALNVDDEVYDKTLENKKVEKGVKLDTELDANDMKELAQVFIKKTEEFTKQPFPVDPYAQLEFAICAVFRSWMGKRAVDYRREFKITPEQADGTAVSVVSMVYGNMGNDSATGVCFTRDPGTGENMFFGEYLKNAQGEDVVAGIRTPQIISKMAEDADLPGCYEQLLDIRKKLEGYFHEVQDFEFTIERKKLYMLQTRNGKMNATATVRTGVDMVEEGLITKEQAIMRIAPQSVDQLLHKNMPANYAEAPLVKGLPASPGAATGAVVFDADDAVEQAKGKKVLLLREETKPEDIHGFFVAEGILTCRGGKTSHAAVVARGMGKPCVSGAEGIKVDVAKKIAKIGSLEVHEGDILTIDGSTGCVYKGEVPLEEPQVGSGYFGTILKWANEIKKIGVFANADLPSAAKKALEFGAEGIGLCRTERMFNAVERLPIVVKMILSNTLEERKKYLNELMPLQKQDFIGLLKTMNGLPVTVRLLDPPLHEFLPTLEELMREIFEMKLSGKTEGLAEKEVVLKKVKELMEVNPMIGHRGIRLGTTNPEIYEMQIRAFLEATAEVIKEGIKTHAEIMIPNVTEVNELINLRKNVLEPVHEEVEKKYGIKVPFMYGTMVECVRAALTADKIATEASFFSFGTNDLTQGTFSYSREDSENKFIPKYVELKILPANPFEILDRPGVGEVMRIAVTKGRQTRPELLVGICGEHGGEPSSIEWCHMIGLNYVSCSSYRIPVARIAAAQAQIRHPREN
What is the function of this protein?
Catalyzes the dephosphorylation of phosphoenolpyruvate and diphosphate to produce ATP.
What are the official names of this protein?
Pyruvate, phosphate dikinase, EhPPDK, Pyruvate, orthophosphate dikinase.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
Protein: YIDC_CHLTE
Sequence: MDRNSVIGFALIAAIMIVWLQFMKPEQKLGLEKAAASREAVQKTPAAALPAPSAAVAAAARADSLGSFAQASVGTEKTITVSNDLFTATLSSKGATLKSLVLKKHLDGNRKPFNLISASDKGALSMLFLSSDGKKIDTRDLYFRSLDAKTTETVTGKEKLSVSYVLDVDATRSIQITYTFTGDSYVVDYDLKLNGFGSSIAGNEYQLDWDGGLNYSEKDQVDESHNAIASAYLGGSVVKLDAKDAKKTWQDEESGKAQWVAVRNKYFVAAIMPQRTTDGIYLHGTKKDGSDFKNYVAALKMSFPAGQQSVDDHYRLYVGPLDYNTVKSLNADLEKIMDFGWDWLTRPFAEYLILPIFNWMNKYVTNYGLIIIIFAFLIKLVTWPLSLASTKSMKKMSALQPVMKELQEKYKDNPAKLQSELGRIYKEAGVNPLGGCLPTVIQMPLLFAMFYVFRSSIQLRQHGFLWVKDLSVPDSVYHFAFKLPLYGDHIAIMPILMAVTVFFQQKITPNAQSNEQTKIMMWLFPAMMLFFFNNMPAGLALYYLMFNIFSVAQQAYMNATITDEEKAAAAMQVAAATKPAQSAKKGGKKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HLGA_STAAS
Sequence: MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
What is the function of this protein?
Toxin that seems to act by forming pores in the membrane of the cell.  Has a hemolytic and a leucotoxic activity (By similarity).
What are the official names of this protein?
Gamma-hemolysin component A, H-gamma-2, H-gamma-II.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted.