PharMolix/UniProtQA huggingface dataset:
Protein: FES1_GIBZE
Sequence: MADPRLNELLKWSIEQSEATKNDPDAPPAKTQLTPELMAALMGGPSDADLMKASMEIITSDNAEEVSLDDKLVAFDNFEQLIENLDNANNIANLSLWTPLLDQLKHEEREMRKMAAWCVGTAVQNNEKTQERLLAVGGVPMLVDLATKEDEPVDVRRKAVYALSSAVRNYQPAMDLFADELTKKGHKTDKVDATSMEAVDEVVNGLREKIGKA
What is the function of this protein?
Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP.  Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
What are the official names of this protein?
Hsp70 nucleotide exchange factor FES1.
What is the protein family that this protein belongs to?
Belongs to the FES1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_PSEPG
Sequence: MSSKPPAIFLMGPTAAGKTDLAIELTKVLPCELISVDSALVYRGMDIGSAKPSKEILAAHPHRLIDIRDPAESYSAAQFRADALEAMAEITARGKIPLLVGGTMLYYKALIDGLADMPAADAAVRAELEAQAEALGLAELHRQLAEVDPVSAARIHPNDPQRLIRALEVYRVSGESMTAHRQRQFAESRGADAGAGGHLPYTVASLAIAPTDRHILHQRIALRFSQMLEQGFVEEVRSLRARSDLHAGLPSIRAVGYRQVWDYLDGKLTENEMRERGIIATRQLAKRQFTWLRGWPEVHWLDSLACDNLSRTLKYLGAISILS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: END8_ECO81
Sequence: MPEGPEIRRAADNLEAAIKGKPLTDVWFAFPQLKSYQSRLIGQHVTHVETRGKALLTHFSNDLTLYSHNQLYGVWRVVDTGEEPQTTRVLRVKLQTADKTILLYSASDIEMLTPEQLTTHPFLQRVGPDVLDPNLTPEVVKERLLSPRFRNRQFAGLLLDQAFLAGLGNYLRVEILWQVGLTGNHKAKDLNAAQLDALAHALLDTPRLSYATRGQVDENKYHGALFRFKVFHRDGEPCERCGGIIEKTTLSSRPFYWCPGCQH
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: YIDD_DICT6
Sequence: MRGLLIILIKFYKKFISPVLPKSCRFYPTCSTYALEAIERFGAFEGGILAIKRILRCHPFNPGGYDPVPTKEEFLELKLKRRKNK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TLL1_HUMAN
Sequence: MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK
What is the function of this protein?
Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase.  Required for the embryonic development.  Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
What are the official names of this protein?
Tolloid-like protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: EMB74_ARATH
Sequence: MTTTRAKSKFQSLSACRFTPLPEPNTSPSTYSKTLPKPNSSPGTDGTFPTPFPLAVITPIKTLKSVTLSDWWLTKKGKDLCIKGFESNGASGVRLFSSGTISKRHESTTLEAIDGITISINGFINRSRCLENGISIEVCNRFRLGFPYDWEDYNEEEEEKKKKNVDISFDDIPVNRYQDLYSLEGCLKDKILDDVVGSLRDLVCQKSDKACEKSRVGDVDDDDDDDDDKSLVSRVVGVKTRGMLRRREEYEASIGKRVATMSGKRVVTVSKKKNRRRSFGW
What is the function of this protein?
Required for normal embryo development.
What are the official names of this protein?
Protein EMBRYO DEFECTIVE 1674.
Protein: RXT3_SCHPO
Sequence: MEEKTPENEQSKKTFDPKDSMKIEETSTNGSSQPSQPSNIKLSIGSILESSNDNGDPEYSENGMGNMNMNTLPMATSTPMSYTKQPSEAKYPNSVWERKGVSDQEENTSSVKRQKTLPTQSSGEEEAKYSHPGAPTATSADSISMESRPSNLSTSLSKTTSYPQFQVRQFVSPIISIDNSALEPFLNRYPASESLFPVTEYEYTPWLEFPLLYSSIGKFVRVTIDIKWLNAAINPRLCRREIWGTDVYTDDSDIATILAHCGCFSLLKPVRKIAVVDLYILPPLVHYKGTRKNQIESRSWSSRQDGISLKIKEVTWKPACASIFENSIHTLTLEERLQARLELSRSSTFKI
What is the function of this protein?
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).
What are the official names of this protein?
Transcriptional regulatory protein rxt3.
What is the protein family that this protein belongs to?
Belongs to the RXT3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SFH5_YARLI
Sequence: MSIPAHLQILQPSELEALKKLQDELPKILEKTDYNEMYGHKLSEAEDGPGKAYSEVKRDIILLKFLKARDYDIAQTKDMLTDALKWRKEFDPLDCASAKHDSKFDKLGVITDKGAGGEPQVTNWNLYGAVSNRKEIFGDLKGFLRWRVGIMERSLALLDFTKPGAGSMLLQIHDYKNVSFLRLDAETKAASKETIRVFQSYYPETLERKFFVNVPTLMQFVFGFVNKFLSRETVAKFVVYSNGKDLHKSLGSWVPAEYGGKGGPLLEMAISDHPVQEAETKETKEKEKETEKPVGTSETDTVGDAAEPAPTEPAAETVPTTEPAPTEPAAETAPTESSTAPSAEPAAETAEPVSEGAKVAAQ
What is the function of this protein?
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity.  Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.  Heme-binding protein that may play a role in organic oxidant-induced stress responses.
What are the official names of this protein?
Phosphatidylinositol transfer protein SFH5, PITP SFH5.
What is the protein family that this protein belongs to?
Belongs to the SFH5 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: HXA1_MOUSE
Sequence: MNSFLEYPILGSGDSGTCSARAYPSDHGITTFQSCAVSANSCGGDDRFLVGRGVQISSPHHHHHHHHHHHPQTATYQTSGNLGISYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGYPPCAPAVYSGNLSTPMVQHHHHHQGYAGGTVGSPQYIHHSYGQEQQTLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGSDEKTEESSEKSSPSPSAPSPASSTSDTLTTSH
What is the function of this protein?
The homeoboxless ERA-1-399 protein could act as a competitive inhibitor of the ERA-1-993 protein by competing for interaction with regulatory protein(s) while being unable to bind to DNA.
What are the official names of this protein?
Homeobox protein Hox-A1, Early retinoic acid 1, Homeobox protein Hox-1.6, Homeoboxless protein ERA-1-399, Homeotic protein ERA-1-993.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Labial subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PNCC_SHEON
Sequence: MKLEMICTGEEVLSGQIVDTNAAWFASTMMEHGIEIQRRVTVGDRLEDLIAVFQERSLHADVILVNGGLGPTSDDMSAEAMAKAKGESLVENSEWRQRLEDWFTRNNREMPVSNLKQAMLPVSAVMVDNPVGTACGFRVKLNRAWLFFTPGVPFELKHMVKEQFIPFIRDEFNLDAKVALKKLLTIGHGESALADKIEPLELPEGITIGYRSSMPHIEIKIFARGEKAIALLPRVAGHIKMVLGTAVVAEDKATLAEEIHFRLLNSGLTLSAAESCTGGMITSQLVDFPGSSSYLQHGLVTYSNESKVRVLGVNPATLDDHGAVSIPTVEEMAKGARAILDSDFALATSGIAGPDGGTEDKPVGTVAIALATRSGVYSQMIKLPRRSRDLVRSLSAAVAYDMLRRELLSEAVIVDYQSIGRFSK
What is the function of this protein?
One of the key enzymes of the pyridine nucleotide cycle which permits cells to recycle the by products of NAD consumption back to NAD.  Has no activity on NAD, NADP, nicotinamide or nicotinamide riboside.
What are the official names of this protein?
Nicotinamide-nucleotide amidohydrolase PncC, NMN amidohydrolase PncC, NMN deamidase, Nicotinamide-nucleotide amidase.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: FMP27_YEAST
Sequence: MMFPINVLLYKWLIFAVTFLWSCKILLRKLLGINITWINLFKLEICGLSLEDGTVRLKSVRFAVFERKLFIKGLRIDSKKSSTNDLHKELPREEERTFIETPEDNGGGFISKILSLSQYWLNGVTIILEDTQLVNNDITIEKFGFFLSIDNSKHIKSLRFDSFLRKLLWNGQTIIADAIFIVNTNLLIGEIMNPLKDGLQVGLDLKLGDLNIPMNLLNLFINKENVDLMSNEKLLQRLADTTKANEELKDEDIAKMKDDLVYAMEKFVDRIKPLKEMNVTVDKLQIKDFPLTNHPELLGMNKYISYNVLVSNINFNTNRFRNEMPGYTLIFEERDSPFKFSIIMARFNIYLNLNRKHQSHAKQLKIIEIPNVSIFGETNLFSQKFRLSNNLHAKELENAIFNIKGNISSLTIDMDPVNISFIKCFLSNIKVFTSSCPKNKILKENSHVKFLTRRRVLFDYFKCFLPLINMKFTLDDPKFVINDKDDLIIGKFSVFMISHHSKRYTLGNNLMEEKEETQHIFYESHWNVELLDMKLQHIIKHQKYEHTILRVDSIAIEEKVQLLPDILCSANADIDTLMLDLSELPTMVMLSELVHNLDSQLANVEENYFKEFYEKFASNLQNMKAECSNMAKCLRQKEILPSDFMFQQLPDFFDYIKINIRDISSTLGARSVFMPRDVFSSVDSQSSKDLIDGKLRKYCNTVEKLQIALFGDKTQWHNKIGSNHATMVRSGQLTNFSKDNKQNPNHKSSIADLDDISTSDATEVNHLWNINLLVNDITTSIIGETPEVSEELSTKTVSKVSNLSIKLFPDTESFSSNESDSKIILQINHSRGTSVVSLMSIFLAVSGIHTLNQIFGHCIHQKMRQSKTKQYFLALSESKKKSCIKSIKWGQLKELLEINFSSEYISQIIALPNGLRTKFEPTSTFITVKNCNTISVSGQYFRMMVESPTQPNFWERMICINGFKVMIHIDLLKQQMKKLNSLQNWEKLPSAITLENDSWHFSIPHHFEMFKIIDSIPTIFKSIKQMLYSLKTSKDDLIIFPHKIETPLSLPKIKLKSKRWLFSISDDPLEAELNTIFQIGLQEQRERLAKLQEFNKRISEDLIKSQKNAKEMKDDFEAIDNAILKHRTGLWAKDGKKRLRKSATDSEIPLTPAALNINGKRDDRPDRTQFISPEIENAYNTLLANFSDSWIKRVKEYKVKERREFDKNFSFLWGFIDYTKLPKDINKKVLPFSTNPFLMNLIIENIDIDIIRPSCGIENIPNFIHDVGKGVPKNTEYSIMIPMHLDAKFSEVRWHLRDYPLPFVSIPPLSSTQSKETIPMRIYGDFMITEDMLQSDRELRTLFVPLIPSVTVENTDRYYSLFVPRTMTSAKIFTDLNFEINSNHTTRVTWGGSYQPAIQQTMQCLDNFSKPPLDPSVKLGFWDKTRYLFHGKINIVWKKRGKFEISLKGAKSPYMLGGESAGFIVGFDGNVNLKCNEDNDPKKFLSCSADKVHFSIPNYFAKPLLVWSRPSTNTMFIPNQDDTNMQRYASFYYLLNTTSSKNEKADKEIMGKSFIEKTGIKLSGGMTLDMGILFERLGPSLNERTFESKKHYLTRLCNPIYVQDLSKHDSYAGFRSDFIHMSFGLSSNSNSAYNAMQLSPNGFKAFFVWWKSFSGNFPVRRGPLFGLQSISPKFGEHLYTISYHADVSPLFINYMYHNADADQILRKNYLEVAEFAGLKAKSSHFIMDLHQRKEVLTEYQAGLNVRRRVMKLKFLAGDVVCQDVDIRTVSGEFSKLNYIEEKEDAEYDIFDNDMSWLDITDFQDAFFINPDNYLPKIKIMPFAFSPQFAYQKRASYGDKYQVDPKTCKPITPFDNRVSHGCTLGHNVSLRTDLVEKRVTVLKKFREKLQEGIRKNKSAGVSEENLNDLLSKANSSVENAELLLKDFQKIFKQHEAGQTEQPFHFDSLNLLKNTKKTLKQFEHRFFIFNVLLKWNEDARSAIFKFFYYANLSNEFASLASGKGLREFEDVIKQREMTDDTTSMEAIPEGTDKANTTKQCHSCDDTEFTTENLLNIFEKNITQLSCDIKNKIHHKFFVQFITPQIQLTSLENPEACVLVSSPFFMLKTLEFDANTTSNTYMQDIFLKRHGILFGNANAFLFNKKDYQEFFELYFGSSSYGQDKKEQWPPWLGLELGFEPSALKKKAVVRNISALLHHQKLAPFSAKYDSLKDKIEDNICGYVPQVNVQVNSDEYLMLTKMALKLFLYVEPEDEELKKYIEKLIIGYDIYDTAQTRKFVNDLHDSEQILAVVEKELLFKRSLLDDIGKLDLSNIHNERMHQLLRLYILRKVFTSNGNNYINRTLVWNIKVNETILHLLDKIDKPFLDIAVAKLNFQRIQHTMGLRKNTVTVKMMQIFDLGENVNYHCILGPLITSSGNDTVGLASDVPLVQITWDVDKPVGGIKVVKNVETTLSSLTIKLEEDRLNKLFEWLSLKELIYDGNGDDDDGASSIFDMVSSESEEGKIEFSEDISSDFNEMLKRSSDYMIVEDLKLNSFKLCISYKGKGKMRLANVTNFVFNFPTLRLSNQTLRVTDLLLALKKVLIKVLIKHTGRFIGNKLKRNSKENKIADDTSPLKQLTTYNSYTEPEELR
What is the function of this protein?
Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution.
What are the official names of this protein?
Protein FMP27, mitochondrial, Bridge-like lipid transfer protein family member 2A, BLTP2A, Found in mitochondrial proteome protein 27, Protein hobbit 1, HOB1.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: IFNG_MUSPF
Sequence: MNYTTICLAFQLCVIFCSSGYYCQAMFFKEIEDLKEYFNASNPDVADGGPLFLDILKNWREESDKKIIQSQIVSFYLKLFENFKDNQIIQRSMDTIKEDMLVRFFNNSSSKLEDFLKLIRIPVNDLQVQRKAINELIKVMNDLSPRSNLRKRKRSHSLFRGRRASK
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLAH_ECODH
Sequence: MNALTAVQNNAVDSGQDYSGFTLTPSAQSPRLLELTFTEQTTKQFLEQVAEWPVQALEYKSFLRFRVAKILDDLCANQLQPLLLKTLLNRAEGALLINAVGVDDVKQADEMVKLATAVAHLIGRSNFDAMSGQYYARFVVKNVDNSDSYLRQPHRVMELHNDGTYVEEITDYVLMMKIDEQNMQGGNSLLLHLDDWEHLDNYFRHPLARRPMRFAAPPSKNVSKDVFHPVFDVDQQGRPVMRYIDQFVQPKDFEEGVWLSELSDAIETSKGILSVPVPVGKFLLINNLFWLHGRDRFTPHPDLRRELMRQRGYFAYASNHYQTHQ
What is the function of this protein?
Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG).  Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Glutarate 2-hydroxylase, G-2-H.
What is the protein family that this protein belongs to?
Belongs to the glutarate hydroxylase family.
Protein: VG04_BPML5
Sequence: MSWAGSGRRQELPEDWELNYRLPVLSAANWLCQINGPGCVRAATDVDHIKRGNDHSRSNLQAACHVCHGKKSAAEGVARRRELRARRKRPPERHPGRR
What are the official names of this protein?
Gene 4 protein, Gp4.
Protein: MAT1_PSEA3
Sequence: MPATPPMPGYDAVAVPVLDSTLGNTDIMTRISLTFPTQLSLALLQDSWYELVRAWPILAARVRHTPSTPSGLSFLIPQPDKVKELEQRSRTSHKDQEKHIVIVDASSRSIASFHPITAKAIQSSLSRDTVSVGAAPDNADSLKMTCSNATTSLKQLLRADQAYITAHATVWSDATTIALAFSHIAGDAFSVKAIFEAWRQTIESAAPAPLQGVGVDPFITYLPPHGKNSKSEDTDKQGERDVGLPLGFFQYGFIDKVRLAWNLISDIKIKRPEKKFGQYYMYMPEEKVQALMAQARADVDALVSASDDSEKQALDTRISTFNVLLAWLLQNIHAANPKRKRMSTVMTIVNAKTRPPARHDPSDYPPHQLWGGALGVPLEPLASGDYASLPLGQLALHIRTSLTAQIDPANMQANIVTLLRHTRWAKPSGKLIFFARPNHYLSGCTEWRSTRFGELDFGAAASPPSSVKPVAIGTDMEIAVSKRNRWVIFGDMGGGVWFSGFMTDHEATHRDGFGRYQHVQ
What is the function of this protein?
Acyl-CoA-dependent acyltransferase; part of the gene cluster that mediates the biosynthesis of mannosylerythritol lipids (MELs), surface-active substances that enhance the availability of water-insoluble substrates (Probable) (PubMed:20564650, PubMed:31923270).  Depending on the number of acetyl groups, mannosylerythritol lipids can be differentiated into MEL A (fully acetylated), MEL B and MEL C (monoacetylated at R-6 and R-4, respectively), and the fully deacetylated MEL D (By similarity).  The first step in the pathway is the generation of mannosylerythritol by the glycosyltransferase EMT1 which catalyzes the transfer of GDP-mannose to the C-4 atom of meso-erythritol (Probable).  This reaction has to be stereospecific, since only mannosyl-D-erythritol is generated (Probable).  The produced disaccharide is subsequently acylated with fatty acids of various lengths by the acyltransferases MAC1 and MAC2 at positions C-2 and C-3, repectively (Probable).  The existence of MEL derivatives which carry an acetyl group at C-2 implies that at least MAC1 also accepts acetyl-CoA as a donor (Probable).  The final step of MEL biosynthesis is the acetylation of the fully acylated mannosylerythritol lipids catalyzed by the acetyl-CoA-dependent acetyltransferase MAT1 (Probable).  MAT1 displays a relaxed regioselectivity and is able to transfer acetylgroups to both positions C-4 and C-6 of the mannosyl moiety (Probable).
What are the official names of this protein?
Acetyltransferase MAT1, Mannosylerythritol lipids (MELs) biosynthesis cluster protein MAT1T1.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: RS7_PROMH
Sequence: MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAESIVYNALETLAQRSGKTELEAFEIALDNVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLANELSDAAENKGAAVKKREDVHRMADANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SIP18_YEAST
Sequence: MSNMMNKFAEKLQGNDDSHQKGKNAKSSNKERDDMNMDMGMGHDQSEGGMKMGHDQSGTKMNAGRGIANDWKTYENMKK
What are the official names of this protein?
Protein SIP18.
Protein: Y1212_ARCFU
Sequence: MMKCLLVSSVEGYSGKSGIIIALGLKLREMGYEVGYFKALGVNTVKVGDRAVEEDSLITAKILGVEEDVCPVVLDRPYIDFATSVDPVVLRKAVLDRFTEVSEGKDVVIVEGSQNYRTGVAVGIDDASVAKMLSAKVLLVGKYVNDFVVDEVLAAKSAFGTMLEKVVFNQVSGYKMSYIEGIARKVLNEAGLDIVGAIPRNPVLAGLSVEEIREAVSGEYLIEPREEKMVEQVVIGAMSPQSALRYLREARNAALVTGGDRSDLLLTALEMPNVRCLILTGNLEPVQLVLTKAEERGVPVILTGHDTLTAVSRLESVFGRTRIRGEPKVGIMRELFESHVNVKTIIEYLGLD
What are the official names of this protein?
Uncharacterized protein AF_1212.
What is the protein family that this protein belongs to?
To Synechocystis PCC 6803 slr0039.
Protein: CFBE_METAC
Sequence: MDLFRKKLAVLDLTHGGIPIARKLAALGNDVSGVDVYGTVDQALLGELEEKYGIRCSKAPLPVSDFDLLIAPVHLDPAYPMLIKARSEGKTVLSHHEAVGKILQADPRLSEIKIVEITGVKAKTSTASLLADMLSRSFKVVLHTSRGLEAWKAGIPFLIHRGLSITPGSILIAVEKSLEQEIRPEFFIFEISIGATGTADLGILTTLSPDYGIANNTSLASDAKLQLVLNARPGSTLLLNAGAEKALEAAKGSLAKVLTFKDPFCSDSYLKLADAPDFVLETESGAEKNLTLHFLRRGEELFSASLCPGYNSSAYRTAFVAASAAALELGVGLEAIVSVLEEFRGLSGRMQEKELNGVVLVDNSNSGMDILSAEKALEYALLKKKDEKKGNIILILGEEASQVCEGLPPGSVQGFLEKFGTKCRHIILVGERMEAVAAENASYAGSLPEGLQKASELAGTEDIILSSVKCFR
What is the function of this protein?
Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation.  Catalyzes the activation the g-propionate side chain of 15,17(3)-seco-F430-17(3)-acid (seco-F430) for intramolecular C-C bond formation to yield the carbocyclic F ring of coenzyme F430.
What are the official names of this protein?
Coenzyme F(430) synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
Protein: RS5_FRATH
Sequence: MSNEVKKNEELIEKLVSVKRHSKTVKGGRIMSFAALTVVGDGKGRIGVGRGKSREVPAAIQKAMENAKKNMVSVNLNNDTLWYPVVSNHGASKVFMQPASAGTGIIAGGAMRSVFEAVGVHNVLAKTYGSTNPANVVRATIAGLAKIKSPDEIAEKRGLSVEEIQG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: F16A1_PSET1
Sequence: MRRLPPVLLEDGCPRELISLIRTILAACKEISFRVGQGELSGVLGSTLDENIQGETQKKLDVLTNQLLKDILLESGYVKAIASEEEDYTVAGNPDAEYIVAFDPLDGSSNTDINSLVGTIFSVMKAPEGADPADQSIFMQPGINQVAAGYVLYGPSTILALTTGKGTRFFTLDKTHGTFLLTQDFAKIPADTNEYAINASNQRHWQPAMQNYINDLVAGDTGPRARNFNMRWIAAMVGDVHRVLSRGGLFTYPTDTKNPSQPNKLRLLYEANPMAMLVEQAGGIASTGTERIMDIQPNAIHQRVAVILGSKNEVETCLGYHK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1 1, FBPase class 1 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_BACHK
Sequence: MDNMNHEELNDQLLVRREKLHNLREQGIDPFGKRFERTNATNDLLSLYGEFSKEELEEKEISVSIAGRIMTKRGKGKAGFAHIQDLHGQVQIYVRKDAVGDEEYELFKTADLGDLVGIEGKVFKTNVGELSVKATGFTLLTKSLRPLPDKYHGLKDVEQRYRQRYLDLITSMESRETFVTRSKIIREMRRYLDDNGYLEVETPMMHAIAGGASARPFITHHNALDMELYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYKDIMKLTENMVAHIAKQVLGTTTIQYGDYEINLEPEWTRLHMVDAIKEHSGADFWNPMSVEEARELAKEHNVEIKDTMEVGHIINEFFEQKVEDKLIQPTFIYGHPVEISPLAKKNDEDPRFTDRFELFIVAREHANAFTELNDPIDQKERFEAQLKEREQGNDEAHMMDDDYIEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPAMRHKQD
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_HALH5
Sequence: MLVSYQWLKQYVDLDGISAEEVAEKLTRGGIEVDIIHDLNQGATGVVVGHVLECRQHPNADKLNLCQVEIGEEEPVQIVCGAPNVAAGQKVAVAKVGAVLPGNFKIKKAKLRGELSQGMICSLQELGVENKFVQKEFADGIYVFSDDVEIGSDALEALNRYDQVLELDLTPNRSDCLNMYGVAYEVAALFDKEVHWPTAESSGTDGQASDYVSVEIEDIEKNPYYGATIIKNVKVGPSPLWLQNRLIAAGIRPISNVVDVTNYVLLEYGQPLHAFDYDRLGSNKVVTRLAKEGEKMVTLDDVERTLQADHLLITNGRDPVAIAGVMGGATSEVQEDTTTVLLEAAYFDPATVRKASRDLGLRSDSSSRFEKGVDPKRVREAAARAATLIAEVAGGTVVGGVVEAGELAIEEPVVSLNLPHMNQRLGMELSHDEVAAIFDRLGFAYTVENDTFEVTAPSRRGDIRIEEDLFEEVARLYGYDNIPTTFPVGGTTRGGLTDYQQKRRKIRRYLEGAGLFEVMTYSLTSEEKEKGLQGENEDYLPIRVAMPMSEERSTMRTSLVPHLLDVVQYNLNRKQEALFIYELGSVFLSKEETLTKQPEEREMLAGALTGFWTEHLWQGEKKAVDFFVVKGILEGMFAELGLSEKVTFERGEQPGMHPGRTANVKVNGRAVGFAGQIHPERQSELDLKETYVFQLDVESLLTEEGTEVAYEPLPRFPAISRDIALVVDENVTAAQLQQVIEANGGEWLKHVYLFDLYEGEHMEAGKKSIAFSLTYFDPERTLTDEEVTAVHEQILKELEASTGAVLRG
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
Protein: SPX_LISIN
Sequence: MVTLYTSPSCTSCRKARAWLEEHDIPYKERNIFSEPLSLDEIKEILRMTEDGTDEIISTRSKTFQKLNVDLDSLPLQQLFELIQKNPGLLRRPIIIDEKRLQVGYNEDEIRRFLPRRVRTYQLREAQKMVN
What is the function of this protein?
Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes.  Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP).  This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
What are the official names of this protein?
Global transcriptional regulator Spx.
What is the protein family that this protein belongs to?
Belongs to the ArsC family. Spx subfamily.
What are the subcellular locations of this protein?
Cytoplasm.