PharMolix/UniProtQA huggingface dataset:
Protein: NPIIA_NEOFI
Sequence: MKITALASAILAVVHGALALPARAPALDITLSQVNNTRIKAVVKNSGSEKITFVHLNFFNDPSPVKKVSLYRNATEVEFTGIKQRLRSDGLSNEALTTLAPGATYEDEFDIASTANLTQGGPVTVRTQGFVPIAMNNKIAGYIPYSSNELELEVDAVKAVAVPASIKPLDRRTKITSSCTGDRAAVLNTALRNAASIAGKAANAASSGSSALFAEYFKSTSGNIRSAVAARLKAVASEASLNGGGSTTYYCSDPYGYCDSNVLAYTLPSTNEVVNCELFYTLQEVTNDCHGQDQATTIIHEFTHAPGVYPPGTEDLGYGYSAATALSANNALNNADSYALFANAVYLNCQGQTGGQTMWDGNSQPGQTAPGTQTMWDGNSQPGQTEPGTQTMWDGNSQPGQTEPGTQTMWDGNSQPGQTEPGTQTMWDGNSQPGQTEPCTQTMWDGSSEPGQTEPDAHTTWGNFYQA
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Shows high activities on basic nuclear substrates such as histone and protamine (By similarity).
What are the official names of this protein?
Neutral protease 2 homolog NFIA_031120, Deuterolysin NFIA_031120.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ICPA_DICDI
Sequence: MDSIKKNTINRINGLPINHNNLSKTSIISMDDDYNSNSSFYSTNNSILNSVTKNSNYLNNNNNNNNNNNNNNNISISNCNNNNTNNKINEQLKTFNNIFEEKGEFLKEEIDNKFNDIISLMNQSKNQLFLSLNDIDSLYDLSPLSTTSTITLENNNNNNNNLIKFKLFNNDSIKKYILPVSSKTIKFKQRQILIEQQEFNEKHNQQKHLLELQRQQVLSDQQNQFQEQHKQQLSLKQQELEAIQQDTNKVKQQLIETHDKLLIEKEKQFKQDLNSLELNLQNKFTNEYQSKEQEFNKKLEQQQQQLEKQFQQTKELLIVQETLTLKSKLTTEFQEQLKTHQDQINKQELLLKQQEYQLFLKQQEISSIQKQHQDDLSSLKSKLSSDQDQIKKQLLQQESDLLKKQQELLLKQQELDIQSKQLKEEQEKQQQQQEKQQEKQQQQQPVVVPVKPTTSTVVSATTATLIKAPIVSTTTVSTATVSKLVTNGIAKPTPLTTMKQTVTAVPTLMDNKTRLKKLVPTATTTTTKEENNKEYDKMMQELDTQPNNSNLKNLNEKKLETLKQQLTFDDSVSFSNGNDESSINLSKYLEETNKSVENTFDIMSNTLKRKNEPIQQPSSSSSQLSSSQQPSSSSSSSSSSIGLKKRLSDDKTTIVTSKPTNKVQPQSLNSNINNNVVPPSPVAAIANKLKKQQELEKLKLEEEERLRKKQEEQLAKREVEKEQERLEKKKKNDEKRKKVEENQQQRILEEEKKKKEAEDRELARKHKEDSDKKKREEEEDAKKRIQERFRETQEQERKREEFKKQQQEQELARIKKEKLQQEKLQQEKEKQEKQKQQQQQQEEEQQKKKTVQTILPTPQTPSRSANNNYDDAANTASATKAKYALSSILSMVFGATKSPHFKPSTSQDDQDDDDCEDYDGTDENSENEAKGEYQDDSDQEIEEQFENDSDESMASTESNGDIYFNKNKNSNNSNNNNDVNQSRKDKSIVFDSDSLNRNHNDSNNSSEEEEPERDPVFLTPLPKILSNMKNNNNNNTYSNSPVIKGLSPPSSVSDYSPSSESNDCFSPLTPTNNNKINNNKINNNNSNNNSFNNSNSYRGLSPAQIIESHTPKCINRSGESKTSPFLTIRNTPSPLKNSPIKFNMSSASSLSSFDSDNDSDYNDNDIDDGEILGNPNENFTTPLKNQENNNNNNSNNSNTQYPIITSPPSNEDGDENYYFEEEEIDYEYDKRVPDWAKNHNLDNSLKQQRFYDPDRIFSMIGPVYLYEIFPKQDLGGKIKDFSKVKRNLSSDWSRDCNTEKEDISYKKNMGFTNPIIVNKK
What is the function of this protein?
Chromosomal passenger protein that seems to be required for chromosome segregation and the onset of cytokinesis during mitosis.  Plays a key role in the abscission of daughter cells at the end of cytokinesis and in the establishment or maintenance of a bipolar spindle.
What are the official names of this protein?
Inner centromere protein A, DdINCENP.
What is the protein family that this protein belongs to?
Belongs to the INCENP family.
What are the subcellular locations of this protein?
Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Nucleus. Cleavage furrow. Note=During mitosis, found in the spindle midzone and poles. During cytokinesis, found in the cleavage furrow. During prometaphase, found concentrated adjacent to the condensed chromosome. During metaphase, found concentrated in the middle of the spindle surrounded by chromosomes. After the onset of anaphase, moved to the spindle midzone and spindle poles where it remains through late telophase. After initiation of the cleavage furrow, found increasingly concentrated at the furrow area, especially at the cortex area. By the abscission stage of cytokinesis, found highly concentrated in the thin cytoplasmic bridge connecting the two daughter cells.
Protein: TIP_HUMAN
Sequence: MAAAGRLPSSWALFSPLLAGLALLGVGPVPARALHNVTAELFGAEAWGTLAAFGDLNSDKQTDLFVLRERNDLIVFLADQNAPYFKPKVKVSFKNHSALITSVVPGDYDGDSQMDVLLTYLPKNYAKSELGAVIFWGQNQTLDPNNMTILNRTFQDEPLIMDFNGDLIPDIFGITNESNQPQILLGGNLSWHPALTTTSKMRIPHSHAFIDLTEDFTADLFLTTLNATTSTFQFEIWENLDGNFSVSTILEKPQNMMVVGQSAFADFDGDGHMDHLLPGCEDKNCQKSTIYLVRSGMKQWVPVLQDFSNKGTLWGFVPFVDEQQPTEIPIPITLHIGDYNMDGYPDALVILKNTSGSNQQAFLLENVPCNNASCEEARRMFKVYWELTDLNQIKDAMVATFFDIYEDGILDIVVLSKGYTKNDFAIHTLKNNFEADAYFVKVIVLSGLCSNDCPRKITPFGVNQPGPYIMYTTVDANGYLKNGSAGQLSQSAHLALQLPYNVLGLGRSANFLDHLYVGIPRPSGEKSIRKQEWTAIIPNSQLIVIPYPHNVPRSWSAKLYLTPSNIVLLTAIALIGVCVFILAIIGILHWQEKKADDREKRQEAHRFHFDAM
What is the function of this protein?
Modulator of T-cell function.  Has a protective effect in graft versus host disease model (By similarity).
What are the official names of this protein?
T-cell immunomodulatory protein, Protein TIP, Integrin-alpha FG-GAP repeat-containing protein 1, Linkin.
What is the protein family that this protein belongs to?
Belongs to the TIP family.
What are the subcellular locations of this protein?
Secreted. Membrane; Single-pass type I membrane protein.
Protein: LOLA_ACTPJ
Sequence: MKKLLKQSLLGFALVSMTGAAFADAQSVAELQRRLEQVSQYSADFDQTVRSSKGKQIQSGKGKFQVKRPNLFRMDTKSPQENLIVSDGANLWFYDSFVSQVTVNTVQDAVNNTPFVLLTSSDKSHWDQYDVTQNADTFVLKPKSKKSNLKQFDVRIDQSGMLKGFSTIERDGQSNLYVLRNITGGGVSSDLFKFSVPKGAELDDQRGGKKSKK
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: KDGD_PSEU2
Sequence: MNPQELKSILSSGLLSFPVTDFNAQGDFHRAGYIKRLEWLAPYGASALFAAGGTGEFFSLAASEYSEIIKTAVDTCATSVPILAGVGGATRQAIEYAQEAERLGAKGLLLLPHYLTEASQDGVAAHVEAVCKSVKIGVVVYNRNVCRLTPTLLEQLAERCPNLIGYKDGLGDIELMVSIRRRLGDRFSYLGGLPTAEVYAAAYKALGVPVYSSAVFNFVPKLAMDFYHAIARDDHQAVGKYIDDFFLPYLEIRNRKAGYAVSIVKAGAKIAGYDAGPVRAPLTDLTSDECDMLAALMDKQGKQ
What are the official names of this protein?
Probable 5-dehydro-4-deoxyglucarate dehydratase, 5-keto-4-deoxy-glucarate dehydratase, KDGDH.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
Protein: PUR9_STAHJ
Sequence: MKKAILSVSNKSGIVEFAKSLIKLDYELYSTGGTKGALEDASVPVKSVSELTQFPEIMDGRVKTLHPAVHGGILADRDKPEHLEQLSEQHIDLIDMVVVNLYPFQKTVAKPDVTEAEAIENIDIGGPTMLRAAAKNFKHVTTIVHPADYNEVIERIKEDRLDEDFRKELMIKVFAHTNEYDHAIVSFFKGDSEQLRYGENPQQSARFVRTSNSKHTIAGAKQLHGKALSFNNIKDADSALSLVKKFKESAAVAVKHMNPCGVGIGDNIETAFKHAYDADNQSIFGGIIALNRTVTSDLAETLHAIFLEVVIAPRFTDEALDILTKKKNIRLLEIDMTIDNREEEFVSVSGGYLVQDKDNFEVAKEDMKVVTDKAPTDDQWDAMLLGWKVIPSVKSNAVILSNTKQTVGIGAGQMNRVGSAKIALERAIEINDNVALVSDGFFPMDDTVELAAQHGIKAIIQPGGSIKDQDSIDMANKYGIAMVTTGMRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: MUTL_PECAS
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGSGIGKDELTLALARHATSKIATLDDLEAIVSMGFRGEALASISSVSRLTLTSRTAEQSEAWQAYAEGRDMAVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFTHIDEVVRRIALARFDVAITLHHNGKLMRQYRAAPDKNQYERRLGSICGATFLQHALAVSWQHGDLTIHGWVADPVGAKQLPDMQYCYVNQRMMRDRLINHAIRQAYQDQLSDEQQPAYVLYLEIDPHQVDVNVHPAKQEVRFHQARLVHDFIYQAVMSVLQQASAPRLDMTEPETGKPVQWQQENRPAAGENHFAQPPRTTNSPSYSGKAPRTGQARESANSGYQPENPYQKKQDELYKALLQPTDNGASTPPSGIAAPSTVLHDSCPNRTATNTAASNNKQRALVESPLESQSTGFGRVLTVYPPCYALLEYHKGLAILSLPVAERYLKVVQLTPSEEGLRAQPLLIPQRLTLSKSELNVLSTHHTLLTRFGIDVFVESQRATLRAVPLPLRQQNLQNLISELIGYLADYQTVETQQVEPDALASWMATRLQSEQENWSHSQAIQLLADVERLCPQLAKTPPSELLYMMDIHDAIKALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RNPH_COXBR
Sequence: MRPSKRAANELRPLSFTTQFTRYAEGSVLVTLGNTKVICNASIVEGVPRFLKNSEQGWLTAEYGMLPRSTHSRMDREASRGKQGGRTVEIQRLIGRSLRAALDLKLLGPYTITIDCDVIQADGGTRTAAINGSCIAMIEALRHLQRKGILQTDPLKHKVAAVSVGIYKGVPVLDLDYAEDSNAHTDMNVVMTDNDAFIEIQGTAEGDAFHAKELDALINLARHGIKQIIEKQQEALS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: YD032_YEAST
Sequence: MAPCQGRPKIVIQTSSAYILLGYLEILRQIVLPPQRNLPQMTLPLSRCQTLPVAAVVCTVKHSSVLLNLNILPALLSDLNRLPNQYAHIFNVLVCFQTFILLQ
What are the official names of this protein?
Putative uncharacterized protein YDL032w.
Protein: ERA_PELPD
Sequence: MKNNVNRFGYVSIVGRPNVGKSTLLNRIIGEKIAITSDKPQTTRNRIQGIHNIANGQIVFIDTPGIHACHSRLNKGMVDAALAALRGVDLLLLVVDAGGAIDDRLVRDVLGGTGTPVMLVLNKVDLLADKRVLLERMAAWSQLYPFREILPISAGSGEGVDGLIETVCGYLPEGQPLFPDDILTDLPERFIVAEMIREKIFRLTRDEIPYSTAVTVESFTERPNGVVAISAAICLERPNQKGIIIGKKGEMLKKIGSQARHDIERLLGTRVFLELFVKIEENWSERTSKLREFGYE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: RSMA_ECOUT
Sequence: MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAAKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMRAENISVAQYCQMANYLAENAPLQES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAR8_PRAMA
Sequence: ARSDNFVRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-8, FMRFa-8.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ANS1B_MOUSE
Sequence: MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQDYLEGAGRSAAVLEEHAQEDTAQETHLSSPAESPQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEDEEEDPNSCGPTGLWEALTPCNGCRNLGFPMLAQESYPKKRNFPMEMEPSASLDTFPSENENFLCELVDTAVTKKPCSLEIARAPSPRTDNASEVAITAPGTSHHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFQRMNHNQEYFEISTSTGCTSFTSSPAASPPTSSVETTEVKNEGAEHADDLSQQEDDEPPKEYDAGQFAGLLHGSSPACESPENPFHLYGKRNTCEDGPDEASLANSPLPFKQTPIENNPEPSVKKVKPKVVSRTIFHKRNHQLENHTIVGTRMSRSGSRNGDQWGVNPGGFVERACTLGRIRSLPKALIDMHLSKNVSKSDSDLIAYPSKDKARVNWSKSSTAERSSKDNSERTPSFTSEWEEIDKIMNSIDVGINSELEGMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDSVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWELELINVLKISLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCRKSTEQMKKVPTIILSVSYKGVKFIDAANKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF
What is the function of this protein?
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
What are the official names of this protein?
Ankyrin repeat and sterile alpha motif domain-containing protein 1B, Amyloid-beta protein intracellular domain-associated protein 1, AIDA-1, E2A-PBX1-associated protein, EB-1.
What are the subcellular locations of this protein?
Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. SUBCELLULAR LOCATION: [Isoform 4]: Postsynaptic density. Cell projection, dendritic spine. Nucleus.
Protein: Y1565_METJA
Sequence: MDNNEIIGYTIGETRIDELTFLAKEAPKVGDYVKINYDDSELLGMVESTIQGNMALEDILNIEHLEKIREFEDNSSYYILGKIKVLGDIRDLNKDGALKLPRVPPKPGIPIYRADDELLKKVFGNGHLKIGHLVTREDVEVKLDANKLCSRHLAILAMTGMGKSNTVAVLLRELNKLKATVLVFDMHGEYKDIYCESEKLRVHIIEPKINIYRINDDDLCDLAGVDAQATKQRPYIRKAIKEIKEERKEHDFSTVDDYINAIIGKLEEYKSNDNYKKDESSIQTAIFRLEDMLQFRKNIITLHYNPINDIREHYINIIPMEELDENAVDIVVSYIAKAVLDDRKRIIIDKGRDFAKPIFMIFEEAHLIAPQHRKTRAKHYLSRIAREGRKFGVGLCLVSQRPKTLDAETLSQCSNLIISKLIEPTDQKHVQMASENLSEDLVKQLTSLNIGEAIILGPCIKVPAIVKVDKFDGRYGGEDLNLVELWEKDFINTERLKTDDIEENAFGDDDLFS
What are the official names of this protein?
Probable helicase MJ1565.
What is the protein family that this protein belongs to?
Belongs to the HerA family.
Protein: SLA_PROFL
Sequence: DCPSGWSSYEGHCYKPFKLYKTWDDAERFCTEQAKGGHLVSIESAGEADFVAQLVTENIQNTKSYVWIGLRVQGKEKQCSSEWSDGSSVSYENWIEAESKTCLGLEKETGFRKWVNIYCGQQNPFVCEA
What is the function of this protein?
Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factor IX (F9) (but not factor X) in the presence of calcium with a 1 to 1 stoichiometry.
What are the official names of this protein?
Snaclec coagulation factor IX-binding protein subunit A, IX-bp subunit A.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1319_MYCTU
Sequence: MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT
What are the official names of this protein?
Uncharacterized protein Rv1319c.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SPEB_ECO7I
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHNRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLAAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPNHSVQIGIRTEFDKDNGFTVLDACQVNDRGVDDVIAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: W_SENDZ
Sequence: MDQDAFILKEDSEVEREAPGGRESLSDVIGFLDAVLSSEPTDIGGDRSWLHNTINTPQGPGSAHRAKSEGEGEVSTPSTQDNRSGEESRVSGRTSKPEAEAHAGNLDKQNIHRAFGGRTGTNSVSQDLGDGGDSGILENPPNERGYPRSGIEDENREMAAHPDKRGEDQAEGLPEEVRGSTSLPDEGEGGASNNGRSMEPGSSHSARVTGVLVIPSPELEEAVLRRNKRRPTNSGSKPLTPATVPGTRSPPLNRYNSTGSPPGKPPSTQDEHINSGDTPAVRVKDRKPPIGTRSVSDCPANGRSIHPGLETDSTKKGA
What are the official names of this protein?
Protein W.
Protein: TGT_CITK8
Sequence: MKFELDTTDGRARRGRLVFDRGVVETPAFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRDRFDGLGNKNALFGIIQGSVYEDLRDISVKGLVEIGFDGYAVGGLAVGEPKEDMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKHKSDTSPLDAECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGRPVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: ELK1_MOUSE
Sequence: MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSAIAMAPATVHAGPGDTATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYSTFTIQSLQPQPQPPIPPRPASVLPNTTPAGVPAPASGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLDPSFGHPQPPEVKVEGPKEELEAARAGGFSSEAVKAEPEVSASEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPERTPGSGTSSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP
What is the function of this protein?
Transcription factor that binds to purine-rich DNA sequences.  Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity).  Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).
What are the official names of this protein?
ETS domain-containing protein Elk-1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS17_PARL1
Sequence: MPKRILQGVVVSDKNEKTIVVNVERRFQDPLLKKIVRRSKKYHAHDENKSAKVGDIVKIRECKPVSKLKKWEVFTDEA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: MURQ2_VIBPA
Sequence: MKIDLSRLVTESRNPASTEIDTLSTIEMLQVINEEDQKVALAVKAVLPQIAKTVNAITAAFANGGRLVYMGAGTSGRLGILDASECPPTYGTHPDMVIGLIAGGHQAILKAVENAEDDVKMGQDDLKALHLTKHDVVVGIAASGRTPYVLGGLEYAKSIGATTASIACNPECAMAKAADIAILPIVGAEVVTGSSRMKAGTAQKLVLNMLTTGAMIRSGKVFGNLMVDVEATNAKLIQRQTNIVVEATGASKEEAERALNACDRHCKTAILMILADLDAEQAKSRLAAHNGFIRAALNNN
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase 2, MurNAc-6-P etherase 2, N-acetylmuramic acid 6-phosphate hydrolase 2, N-acetylmuramic acid 6-phosphate lyase 2.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: OPT_MOUSE
Sequence: MKFLAFLSLLSLVLQKAETASLLGEREREEQSPEEGDTYASLYVGNHTLSIEDYNEVIDLSNYEELADYGDQIPEAKISNLTLPTRTSPTSTVAQKTLSPNLTMAVPTTTGLLNSQSSHGLPTCLVCVCLGSSVYCDDADLENIPPLPQMTTYLYARFNHISHIQAGDFKGLTKLRRIDLSGNSISSIHNDALRLLPALQDLILPENQLAALPVLPSGIEFLDVRLNRLQSSGIQPEAFVALKKLQFLYLANNMLDSIPGPLPLSLRSLHLQNNMIETMESDTFCDTGEHRHERRQLEDIRLDGNPINLSLFPEAYFCLPRLPVGHFT
What is the function of this protein?
Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (PubMed:22159013).  Binds collagen fibrils (By similarity).  May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (PubMed:29323130).
What are the official names of this protein?
Opticin, Oculoglycan.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: HDAC2_HUMAN
Sequence: MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
What is the function of this protein?
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).  Histone deacetylases act via the formation of large multiprotein complexes (By similarity).  Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404).  Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity).  Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666).  Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227).  May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity).  Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678).  In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674).
What are the official names of this protein?
Histone deacetylase 2, HD2, Protein deacylase HDAC2.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.