PharMolix/UniProtQA huggingface dataset:
Protein: MYL11_MOUSE
Sequence: MAPKKAKRRAGAEGSSNVFSMFDQTQIQEFKEAFTVIDQNRDGIIDKEDLRDTFAAMGRLNVKNEELDAMMKEASGPINFTVFLTMFGEKLKGADPEDVITGAFKVLDPEGKGTIKKQFLEELLTTQCDRFSQEEIKNMWAAFPPDVGGNVDYKNICYVITHGDAKDQE
What is the function of this protein?
Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (PubMed:17356007).  Plays a role in regulation of muscle contraction (By similarity).
What are the official names of this protein?
Myosin regulatory light chain 11, Fast skeletal myosin light chain 2, MLC2F, Myosin light chain 11, Myosin regulatory light chain 2, skeletal muscle isoform.
Protein: DOF1_ORYSJ
Sequence: MDAAHWHQGLGLVKPMEEMLMAANAAAGANPNPAATAPSSVTGGALRGGGGGGAPPVAGGAGAGSTERRARPQKEKALNCPRCNSTNTKFCYYNNYSLQQPRYFCKTCRRYWTEGGSLRNVPVGGGSRKNKRSSSSAASASPASASTANSVVTSASMSMSMASTGGGASKNPKLVHEGAQDLNLAFPHHGGLQAPGEFPAFPSLESSSVCNPGGPMGTNGRGGGALSAMELLRSTGCYMPLQVPMQMPAEYATPGFALGEFRAPPPPPQSSQSLLGFSLDAHGSVGGPSAAGFGSSAGLQGVPESTGRLLFPFEDLKPTVSSGTGGGGASGGGAGVDGGHQFDHGKEQQAGGGGGGPGGHDTPGFWNGMIGGGSGTSW
What is the function of this protein?
Transcription factor that may transactivate seed storage protein genes in developing seeds.
What are the official names of this protein?
Dof zinc finger protein 1, OsDof1.
What are the subcellular locations of this protein?
Nucleus.
Protein: PQQB_METFK
Sequence: MHIHVLGSAAGGGFPQWNCNCPNCDGLRKGTIKAKKRTQSSICVSADGINWVLFNTSPDILQQIQEFAPLQPGRAIRDSGIVGIVLIDAQIDHTTGLLMLREGQVKREIYCTDMVYQDLTTGNPLLNILDHYCGVNRHDIPIDGKHSFSVEHAPGLRFTAVALKSAAPPYSPHRHDPHPGDTIGVLIEDLNNGKKAFYAPGLGEIEPHLPALMEQADCIMVDGTFWTDTEMLDMGLMSKKARDIGHNPQSGPGGMMEVLDGYPGARRVLIHINNTNPILREDSAERVELTRRGIEVAYDGMDIIL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.
Protein: RS14_RHILO
Sequence: MAKTSSVEKNNRRRKLADQYGPKRAALKAIIMDQSKPMEERFRAQLKLAALPRNSAKIRIRNRCEVTGRPRAYYRKLKVSRIALRDLGNNGQIPGLVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: CBPD_MOUSE
Sequence: MASGRDERPPWRLGRLRLLPPPPLLLLLLLLRSSAQAAHIKKAEATTTTVGGSEAAEGQFDHYYHEAALGEALEAAAAAGPPGLARLFSIGSSVEGRPLWVLRLTAGLGPPPTAAAGLDAAGPLLPGRPQVKLVGNMHGDETVSRQVLVYLARELASGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGLGDSGPPGTSGRDNSRGRDLNRSFPDQFSTGEPPSLDEVPEVRALIDWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKTTGLYSKTSDDEVFRYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGIKGFVKDSVTGSGLENATISVAGINHNITTGRFGDFHRLLVPGTYNLTALSTGYMPLTINNIMVKEGPATEMDFSLRPTVMSVMPGSTEAVTTPGTVAVPNIPPGTPSSHQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVRSTRIHLMPSMNPDGYEKSQEGDSISVVGRNNSNNFDLNRNFPDQFVPITEPTQPETIAVMSWVKAYPFVLSANLHGGSLVVNYPYDDNEQGVATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKDMYLNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPFENELPKYWEQNRRSLIQFMKQVHQGVKGFVLDATDGRGILNATLSVAEINHPVTTYKAGDYWRLLVPGTYKITASARGYNPVTKNVTVRSEGAVQVNFTLVRSSADANNESKKGRGHSTSTDDTSDPTSKEFEALIKHLSAENGLEGFMLSSSSDLALYRYHSYKDLSEFLRGLVMNYPHITNLTTLGQSVEYRHIWSLEISNKPNISEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKRNPVVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKTGHTNAHGKDLDTDFTSNASQPETKAIIENLIQKQDFSLSIALDGGSVLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNNSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAAQLPALWAENKKSLLSMLVEVHKGVHGLVKDKAGKPISKAVIVLNEGIKVYTKEGGYFHVLLAPGVHNINAIADGYQQQHTQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
What are the official names of this protein?
Carboxypeptidase D, Metallocarboxypeptidase D, gp180.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SELO_CHRVO
Sequence: MPEAWAPVRPETPPAPELLYWNAELADELGLDAGQTDKGELARLFSGADIPEGAQPIAQAYAGHQFGGLSPSLGDGRALLLGEVTDRNGQRRDIALKGSGQTPFSRRGDGKAAVGPMLRELIVGEAMQALGIPTTRALAVTTTGEPVYRERPLPGAVLTRVAASHLRVGTFQYFAIRGETAMLNKLADYTIARHYPQLAGRDGRHLALLAAVAERQAALIARWMHAGFIHGVMNTDNMALSGETIDYGPCAFMDAHYPGTVFSSIDHQGRYAYGNQPAIAQWNLARFAETLLPLISPDDPAAAVPAATEIVEGFEDLYQRRWLEQARRKLGLEGERDDDQALADDWLMLLAAHGVDHTLAWRYLADEAEGKGERLAALFPSPDALTPWLKQWHARHVPRTRRPPDIAAAMRRESPLYIPRNHLVEEALDAASERGDMGPTLKLLEALHQPFAERDGLDRYAQPAAAELAEGYRTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: PAOB_ECOLI
Sequence: MKAFTYERVNTPAEAALSAQRVPGAKFIAGGTNLLDLMKLEIETPTHLIDVNGLGLDKIEVTDAGGLRIGALVRNTDLAAHERVRRDYAVLSRALLAGASGQLRNQATTAGNLLQRTRCPYFYDTNQPCNKRLPGSGCAALEGFSRQHAVVGVSEACIATHPSDMAVAMRLLDAVVETITPEGKTRSITLADFYHPPGKTPHIETALLPGELIVAVTLPPPLGGKHIYRKVRDRASYAFALVSVAAIIQPDGSGRVALGGVAHKPWRIEAADAQLSQGAQAVYDTLFASAHPTAENTFKLLLAKRTLASVLAEARAQA
What is the function of this protein?
Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes.  It might play a role in the detoxification of aldehydes to avoid cell damage.
What are the official names of this protein?
Aldehyde oxidoreductase FAD-binding subunit PaoB.
What are the subcellular locations of this protein?
Periplasm.
Protein: RAPZ_ECO45
Sequence: MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPDLARTLADREISAAVSIDVRNMPESPEIFEQAMSNLPDAFSPQLLFLDADRNTLIRRYSDTRRLHPLSSKNLSLESAIDKESDLLEPLRSRADLIVDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVAAFLDRHTEVHNFIYQTRSYLELWLPMLETNNRSYLTVAIGCTGGKHRSVYIAEQLADYFRSRGKNVQSRHRTLEKRKP
What is the function of this protein?
Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ.  When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E.  Consequently, GlmZ is inactivated and unable to activate GlmS synthesis.  Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
What are the official names of this protein?
RNase adapter protein RapZ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family. RapZ subfamily.
Protein: MORC4_ARATH
Sequence: MEPIVKQENPVTTSTLSTWKPAARNKTIPPPESVIELSSSNEGSELGENLDEIAEIQSVDRTGGDDVSGTKRARSDSIASPAKRLAVMIPDDDEEFLLSTTSGQAILALPATPCNVVAAPSSWGSCKQFWKAGDYEGTSGGDWEVSAGGFDHVRVHPKFLHSNATSHKWSLGAFAELLDNALDEVRSGATFVNVDMIQNRKDGSKMILIEDNGGGMNPEKMRHCMSLGYSAKSKLADTIGQYGNGFKTSTMRLGADVIVFSRCLGKDGKSSTQSIGLLSYTFLKSTGKEDIVVPMLDYERRDSEWCPITRSSVSDWEKNVETVVQWSPYATEEELLCQFNLMKKHGTRIIIYNLWEDDEGMLELDFDTDPHDIQLRGVNRDDKNIVMASQFPNSRHYLTYKHSLRSYASILYLKISHEFRIILRGKDVEHHNIVNDMMQTEKITYRPKEAADVSQLSAVVTIGFVKDAKHHVDVQGFNVYHKNRLIKPFWRIWNAAGSDGRGVIGVLEANFVEPAHDKQGFERTTVLSRLEARLLHMQKDYWRSKCHKIGYAKRQGRKSAKDTEKDTEDRESSPEFDPKGSASSRKRTVPSSFKTPTAAPRFNTPTAASEKFNPRSNVNGGGKGSVKVSKDIGYKSSEKGGKLGNSFSKSNKRAKPQGARAVEVTNSDDDYDCDSSPERNVTELPGKSSELPKPQSGPRTLSQLEQENNELRERLDKKEEVFLLLQKDLRRERELRKTLEAEVETLKNKLKEMDKEQASLIDVFAEDRDRRDKEEENLRIKLEEASNTIQKLIDGKARGR
What is the function of this protein?
Exhibits ATPase activity.  Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity.  Probably involved in DNA repair.  Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing.  May also be involved in the regulation of chromatin architecture to maintain gene silencing.  Together with MORC7, acts to suppress a wide set of non-methylated protein-coding genes, especially involved in pathogen response.  Positive regulator of defense against the oomycete Hyaloperonospora arabidopsidis (Hpa) (PubMed:27171361).
What are the official names of this protein?
Protein MICRORCHIDIA 4, AtMORC4, Protein CRT1-homolog 4, CRT1-h4.
What is the protein family that this protein belongs to?
Belongs to the MORC ATPase protein family.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates in discrete nuclear bodies adjacent to chromocenters.
Protein: PYF2_PENMO
Sequence: YSQVSRPRF
What is the function of this protein?
May act as a neurotransmitter, neuromodulator or neurohormone.
What are the official names of this protein?
Peptide tyrosine phenylalanine 2, Pem-PYF2.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: IRX4B_XENLA
Sequence: MSYPQFGYPYSSTPQFLMTTNSLSTCCESNGRSLSDSAAAASAQTPVYCPVYESRLLATARHELNSAAALGVYGSPYTSTQGYGNYVTYGADAPSFYSLNAFESKDGTGSAHAGIPQTAAYYPYEHTLSQYQYDRYGTMDGSTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCSDEKRPYDEEEEEEEDSQKATIKNEKKTVDEEIHREEKALDLSDLEDFDTIESESSECELKQPFHHQPQDGHQLRQRDCVNDHCKEVILKMPITSTATQELDRTKICHKTGLDQCEQDLLRGRQRGGGESKSCFQQQQILDSKPRIWSLAHTATSLNQTEYPSCMLKHQGLSSPSSSSSSSAVSTPVCVIDRRQDSPVTSLRNWVDGVFHDPLFRHSTLNQALTNTTVSWATTKGTLIDSGSLGRSVGNSTNVIKGQLPNLPHDTNKEFIAFQTSGSKMFCS
What is the function of this protein?
Acts partially redundantly with other irx members in neural patterning.  Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord.  Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes.  Does not appear to play a role in pronephros kidney development (By similarity).
What are the official names of this protein?
Iroquois-class homeodomain protein irx-4-B, Iroquois homeobox protein 4-B.
What is the protein family that this protein belongs to?
Belongs to the TALE/IRO homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: THIM_METMJ
Sequence: MPDNTREGSSARFVDGAIPAGLLAAVRSQRPLVHHITNGVTINDCANITICAGAAPVMAEAPEEVAGMVAAAGALVLNIGTLSAAQVEAMLIAGRRANELGIPVVLDPVGVGATEFRTATARKLLDTLDIAVLKGNAGEIGVLAGTGGSVRGVDSGGVAGDPVETARECARSTGTVVSMTGAVDVVTDGSRVFLVGNGNPAMDRLSGTGCMASSVTAAFVAVAEDYAVASAAALAAFGLAGEWGAAGARGPYTFRTALFDELAGLSPDDLAGHARIEER
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RL11_STRLI
Sequence: MPPKKKKVTGLIKLQIQAGAANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGWVIPVEITVYEDRSFTFITKTPPAAKMILKAAGVEKGSGEPHKTKVAKITRDQVREIATTKMPDLNANDLDQAEKIIAGTARSMGVTVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ATL36_ARATH
Sequence: MNIFTRYHLPRVVSGVILPLFLFHLLPYVTCQQESVPTNSIRQTNLSADSIIAIVVLAIFISLGMVSCCLHCIFYREEIGAAGQDVLHSRARRGLEKEVIESFPTFLYSEVKGLKIGKGGVECAICLSEFEDQETLRWMPPCSHTFHANCIDVWLSSWSTCPVCRANLSLKPGESYPYLNMDVETGGVQKLPNERSLTGNSVTTRSRSTGLLSSWRMAEIFVPRSHSTGHSLVQQLGENLDRFTLQLPEEVQRQLVSLNLIRRSHIVLPQAVSSRQGYRSGSVGSERGGFSQGRQTHRRALSMSFSFSFQTASVRSIHDMNDQAQAKDKYFGERSFERLMPEEKV
What are the official names of this protein?
Putative RING-H2 finger protein ATL36, RING-type E3 ubiquitin transferase ATL36.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RRF_STAEQ
Sequence: MSDIIKDTKSRMQKSIDNLSRELANISAGRANSNLLNGVTVDYYGAPTPVQQLASINVPEARLLVISPYDKSSVADIEKAIIAANLGVNPTSDGEVIRISVPALTEERRKELVKEVKKIGEDAKVSIRNIRRDINDQLKKDEKNGDITEDDLRSQTDDVQKATDNSIKEIDQLVADKEKDIMSV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PYGAN
Sequence: MAPNLRKSHPLLKMINNSLIDLPTPSNISAWWNFGSLLGICLTTQILTGLLLAMHYTADTTLAFSSIAHTCRDVQYGWLIRNMHANGASLLFICIYLHIGRGVYDGSYLHKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTIVEWAWGGFSVDNPTLTRFFALHFLLPFMITGLTLIHLTFLHESGSNNPLGIVANSDKIPFHPYYSTKDILGFTLMLLPLTTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLVLFLSPLLHKSKQRTMAFRPLSQLLFWTLVANLLILTWIGSQPVEHPFIIIGQLASTTYFIILLILFPITSALENKMLNF
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y2507_LACP7
Sequence: MSGHSKFANIKHKKEKNDATKGKIFTRLGREIAVAVKEGGPDPNNNNKLKDIVAKAKANNMPNDTIDRSIKKAAGEGNAVNYEFVTYEGYGPSGTAIIVEALTDNKNRTAANVRNAFTKGNGSVGTQGCVSYMFDQKGQIIIDKEECDMASDDLMMLALDAGASDFNEEDDSFEVLTEPDDFSVVRETLEKAGVPMMQAEVTMIPQTWVELSDETDLKNINRTLDLLDEDDDVQQVYHNWDE
What are the official names of this protein?
Probable transcriptional regulatory protein Cphy_2507.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CITX_ECO7I
Sequence: MHLLPELASHHAVSIPELLVSRDERQARQHAWLKRHPVPLVSFTVVAPGPIKDSEVTRRIFNHGVTALRALAAKQGWQIQEQAALVSASGPEGMLSIAAPARDLKLATIELEHNHPLGRLWDIDVLTPEGDILSRRDYSLPPRRCLLCEQSAAVCARGKTHQLTDLLNRMEALLNDVDACNVN
What is the function of this protein?
Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.
What are the official names of this protein?
Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, Apo-ACP nucleodityltransferase, Holo-ACP synthase, Holo-citrate lyase synthase.
What is the protein family that this protein belongs to?
Belongs to the CitX family.
Protein: GLO2_PROMA
Sequence: MKKKEEGFIIHPIPVLMDNIIWIWVKEKQAIVVDPAISEPVINLLKGNGLSLHSVLQTHHHEDHIGGTQELINVWPSASVIAAKSDLDRIQFQTKSVVDNEELDILGQKIKVIEVPGHTSNHICFFLQGSKESKIDPVLFCGDTLFGAGCGRLFEGTPEQMFNSLSRINNLPKNTKIYCAHEYTEANLRWAKSIFPEDIYIEERLKEVILRKSKGFLSIPSKLSEERKTNLFIRASNQREFAQLRLHKDNWKS
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: YCGL_ECO81
Sequence: MPKPGILKSKSMFCVIYRSSKRDQTYLYVEKKDDFSRVPEELMKGFGQPQLAMILPLDGRKKLVNADIEKVKQALTEQGYYLQLPPPPEDLLKQHLSVMGQKTDDTNK
What are the official names of this protein?
Protein YcgL.
Protein: CEP2_ALHV1
Sequence: MGSRERRWLLKHFLNKECLWVKNSASTAVIKVYTSTTARSPLWPGRHAAMPGIEGPINVTVQLMKPKDRKMCATFYVNGVFVDSCTPTAFYCREVQRYGIYLLFFGDLVDPEPPNVIPENIAVHKNEPPVHLTILQMVNSATLLKTPDDLPKPHVEVVPLGPFGPWMANGSLLQYTINPDLLICCPSIGTLPTMSNIITWITKCENEECESCHGNSDHACVLRGVTLADQNYGSDTCPCVAPCSMRHGNIARITTSSNLLGFLFPPESQNDIVAIRAKSNKLTLNVQDIFCGVTREGEEVACLQSPWLLFGLSHLVSRMVMYGCESIKRKCLRSY
What is the function of this protein?
Plays a critical role in cytoplasmic virus egress.  Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid.  Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.
What are the official names of this protein?
Cytoplasmic envelopment protein 2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.
Protein: PLK4_DROVI
Sequence: MLPFRTYGETIDEYEVQHLLGKGGFACVYKAKCLRSHQNVAIKMIDKKLIQGSGLSNRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLILELADNGELHRYMNQQMKRPFTEQEAASILRQVVDGLLYLHSHNIMHRDISMSNLLLSKDMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSHQSHGLPADLWSVGCMLYTLLVGRPPFDTDAVQSTLNKVVQSDYTIPGHLSYEARDLIDKLLRKNPHERISLEQVLRHPFMVKAGGSTISYTTNGASDGYGQSIVSGDSGIVTFASNDSKNSHRLRSVEQQATPQMMPQIQEEYGYYQDHRQKYAPHAAYRQSSAETLDSTEMDWQRMGQNAQKANFLAHSTPAAPVPAPVIRKAGKHNTEHISVPPLNTLRLQPTRYKTKNAIMSIVANGEVVIEFIKSKSKMNEDRIIDICRISGDGRRIIIHQPDPGRGLPIQEQTSETHSSGTDNVYNYDNLPSKHWKKYVYAARFVGLVKSKTPKVTYFSALAKCHLMENMTDFEMNYYSGAKLTKSPSEGIKVFDIHGVQLLDQSSSEAKRLIEHSNECFAHCLSICNALELAQTGSNTCFPVTIGRRPVVEVLPSHRPEGLRDTTNFAYSTPKSQQGSINFSISTISSMRSGSDNIGSQLLAAQQNVPIKRLNVPGVGTATELSHGIVQVQFVDGSVISVIPEAQGGGITYTQSNGVSTHFPDHDDLPLSVRDRLSHLPQVQMKLRCAPLISSKKFDCNAMNAKSTASAPWYNRMLI
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.  Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase SAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: RS19_SHEDO
Sequence: MPRSLKKGPFIDLHLLKKVEKAMEAGDKKPIKTWSRRSMIIPNMIGLTIAVHNGRQHVPVFVTDEMIGHKLGEFSPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: PKHA4_MOUSE
Sequence: MEQGRPRSSLSLASSASTVSSLSSLSTKKPTRAVHKVHAFGKRNNALRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYSVRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGEDCGLPRSPARPRPGEGPGGPGGPPEVNRREEGRISESPEVARLSRGLGRHETHTPNSTVDLQTDTWSRRTRSPELFSPLSRPPSPLSLPRPRSAPARRPPLSAGDISFPARPHTPLSRIDVRPPLDWGPQRQTLSRPPIPRRGPSSEAGGERPPRSPQPRTPEQRTQSTQATSGSSTYLQLPPRPPGTQASMILLPGPPVDSALHQSLETDTLLTKLCGQDRLLRQLQEDLDKRQEEKEQLEAALELTRQQLGQATREAAASGKAWGRQRLLQDRLVNVRAALCHLAQERERVWDTYSGLEQDLGTLRETLEYLLHLGSPQDRACAQQHLWMVEDTLAGLGGPQKQPPHTDPKSPSPAPQGEESSERESLSESLELSSPQSPEVDWSRPSGGDRALSSPQSGVGSPRVSRASSPECRQPSSPLLRTKVDHL
What is the function of this protein?
Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.
What are the official names of this protein?
Pleckstrin homology domain-containing family A member 4, PH domain-containing family A member 4, Phosphoinositol 3-phosphate-binding protein 1, PEPP-1.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: 3L21_LATCO
Sequence: RICYLAPRDTQICAPGQEICYLKSWDDGSGSIKGKRLEFGCAATCPTVKPGIDIKCCSTDKCNPHPKLA
What is the function of this protein?
Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), whereas it binds with a low affinity to neuronal alpha-7/CHRNA7 nAChRs.
What are the official names of this protein?
Alpha-elapitoxin-Lc2c, Alpha-EPTX-Lc2c, Long neurotoxin 1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRF_WOLTR
Sequence: MNPIICALDTQDLNEAISLANTLRDKVGMIKLGLEFFAAHGPSGVREVAKCNVPTFLDLKLHDIPNTVAKTVEAIKVLNIEILTLHISGGTKMLEEALSIVKDTKTKLIGVTVLTSMSNEDLSELGIAREVKSQVILFAKLAKKVGLHGIVCSALEAQEVYQECGKDFKIITSGIRVGFGHDDQKRTATPKEAINSGADYIVIGRPITKSNSPANSAELILKSLS
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: NSCB_ASPFU
Sequence: MALRMPFNQAFWEEYLSGQDATLPSLPDTSTLTSRVIRILGGNPGAMHLQGTNTYLVGTGPSRILIDTGQGLPIWLSRIVGVLQSNNISISHILLTHWHGDHTGGVPDLISYNPTLAEHVYKNLPDLGQKPIEDGQIFAVEGATVRAVFTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAPDLGRYMESLELMAKLGCVIGYPAHGAVIDDLPSKLEEYIRHKEMRVQGILSVLVKERERVEGERGKEGRRKGGMTLHEIARAMFGTVPDEVIDQAMAPFLMQALWKLTEDGKVGFEPGDPVKRKWFAVARRKTRPSIRRQHGSVTSR
What is the function of this protein?
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin, a prenylated anthracenone that exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576, PubMed:23368997).  The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (PubMed:23368997).  The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (PubMed:23368997).  The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (PubMed:23368997).  The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (PubMed:23368997).  There is no gene encoding O-acetyltransferase in the nsc gene cluster; thus, the last step of 2-O-acetylation leading to neosartoricin may be catalyzed by an unidentified O-acetyltransferase (PubMed:23368997).
What are the official names of this protein?
Lactamase-like protein nscB, Neosartoricin biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: CBPO_DANRE
Sequence: MMQASITSILVVLTLVAQDRLAGGLEHKSYDYTKYHTMDEISAWMNQMQRENPDVVSTMTYGQTYEKRNITLLKIGFSSTTPKKAIWMDCGIHAREWIAPAFCQHFVKEVLGSYKTDSRVNMLFKNLDFYITPVLNMDGYIYSWLNNSTRLWRKSRSPCHENSTCSGTDLNRNFYANWGMVGISRNCCSEVYNGATALSEPEAEAVTDFLGAHQNHLLCYLTIHSYGQLILVPYGHPNISAPNYDELMEVGLAAAKAIKAVHGKSYKVGSSPDVLYPNSGSSRDFARLIGIPYSFTFELRDEGQHGFILPEDQIQPTCQEAYEGAMSIINYVHDKNFKNTAITVTATLWTTLMALWISTSHVF
What is the function of this protein?
Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins.  Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.
What are the official names of this protein?
Carboxypeptidase O.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Apical cell membrane; Lipid-anchor, GPI-anchor.