PharMolix/UniProtQA huggingface dataset:
Protein: ICAL_RAT
Sequence: MSRPGPKPAASSRPRRGAAASHTQEHVNEKNIGSSSKPAEKKGSDEVTASSAATGTSPRMSTTGAKAVKIESEKSQSSEPPVIHEKKPKGKPKEGSEPQTLPKHASDTGSKHAHKEKALSRSNEQIVSEKSSESKTKFQDAPSADGESVAGGVTVATASDKVVVKKKEKKSLTPTLPMESTLNKLSDKSGVNAALDDLIDTLGECEDTNKDDPPYTGPVVLDPMDSTYLEALGIKEGTIPPEYRKLLEKNEAITGPLPDSPKPMGIDHAIDALSSDFTCSSPTGKQTEKEKSTGESSKAQSAGVTRSAVPPQEKKRKVEEEVMNDQALQALSDSLGTRQPDPQSHLRQAKQVKEAKAKEERQEKCGEDEDTVPAEYRLKPAKDKDGKPLLPEPEETSKCLSESELIGELSADFVQPTYQEKPSMPAAKIKKGVVPDDAVETLARSLGTRKEDPEDEKSLVDKVKEKAKEEDHEKLGEKEETIPPDYRLEIVKDKDGKPLLPKEAEEQLPPLSDDFLLDALSQDFSSPANILSLGFEDAKLSAAVSETVSQVPAPSNHTAAPPPGTERRDKELDDALDELSDSLGQRQPDPDENKPLDDKVKEKIKAEHSEKLGERDDTIPPEYRHLLDNDGKDKPEKPLTKNTEKLGQDQDPIDALSEDLDSCPPTTETSQNTTKEKGKKTSSSKASKNEEKTKDSSKKTEEVPKPKVDEDAT
What is the function of this protein?
Specific inhibition of calpain (calcium-dependent cysteine protease).  Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
What are the official names of this protein?
Calpastatin, Calpain inhibitor.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I27 (calpastatin) family.
Protein: ACCA_MANSM
Sequence: MSQQNQTEYLDFELPIAELEAKIESLRSVTDQDSKIDLDDEIKRLQKKTAELTKKTFADLDAWQVSRMARHPNRPYTLDYISRIFTEFEELAGDRAFADDKAIVGGLARLDGRPVMVIGHQKGRSVKEKVLRNFGMPAPEGYRKALRLMQMAERFRLPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSTLTVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSAEKASTAAEVMGLTASRLKELELIDNIVTEPLGGAHRQYDEMAQALKQRILSDLEDLDILDKETLLDRRYQRLMNYGYV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LN28B_MOUSE
Sequence: MAEGGASKGEEPEKLPGLAEDEPQVLHGTGHCKWFNVRMGFGFISMISREGNPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSPKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKLAAQLPASSQGRQEAESQPCSSAAPREVGGGHGCTVLFPQEVKSEMAEHSDRSPQEVSSTKAFAAIGEQNKKGPLIQKRKKT
What is the function of this protein?
Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c.  Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA.  Does not act on pri-miR21.  The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation.  When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation.  This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent.  Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop (By similarity).  Mediates MYC-induced let-7 repression (PubMed:19211792).  When overexpressed, may stimulate growth of carcinoma cell lines (By similarity).
What are the official names of this protein?
Protein lin-28 homolog B, Lin-28B.
What is the protein family that this protein belongs to?
Belongs to the lin-28 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: VIRB1_AGRT9
Sequence: MFKRSGSLSLALMSSFCSSSLATPLSSAEFDHVARKCAPSVATSTLAAIAKVESRFDPLAIHDNTTGETLHWQDHTQATQVVRHRLDARHSLDVGLMQINSRNFSMLGLTPDGALKACPSLSAAANMLKSRYAGGETIDEKQIALRRAISAYNTGNFIRGFANGYVRKVETAAQSLVPALIEPPQDDHKALKSEDTWDVWGSYQRRSQEDGVGGSIAPQPPDQDNGKSADDNQVLFDLY
What is the function of this protein?
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
What are the official names of this protein?
Protein virB1.
What is the protein family that this protein belongs to?
Belongs to the virb1 family.
Protein: WDR48_DROSI
Sequence: MLTHKTCQARKKMQVSFVIRDAEEKQHRNGVNALQLDANNGKLYSAGRDAIIRVWNTRTDSSEKYIQSMEHHNDWVNDIVLCCNGRNLISASCDTTVKVWNAQKGFCMSTLRTHRDYVQALAYAKDREQVASAGLDKAIFLWDVNTLTALTASNNTVTTSSLTGSKDSIYSLAMNPSGTVIVSGSTENILRIWDPRTCMRIMKLRGHTENVRCLVVSPDGNQVVSGSSDGTIKVWNLGQQRCVQTIHVHKEGVWSLLMSENFQYIISGSRDRNIIVTEMRNPSNKTLVCEEQAPVLSLGYNIDKTGVWATTWNSDIRCWKLPMYDRCTLNSSGGMDAQWTQGGTEVACIKGGAAIKECAVLNDKRYIITKDSQDQVVVYDVLRVVKKEQLGAVDYEAEVKKRNKQVYIPNWFTVDLKTGMPTIVLGQEEVDCFSAWVSIEAGLPECVDPTTEIKINYGKLLLEALLEYWTPPHSIPPNEMEPDMHGNGYFQVPKHTPVIFSEVGGRTVCRLLVRDAAGDSESTLLHETAPQWVTDVVIEKNIPKFLKIPFFLQPHPQMTKPERTKKDRLVANEFIQCRKVCEHVLEKVLNAETTPSGGNANNSLQNSQSDANSEGSQLPAEERIELWCNDVVVDPNMDLRTVRHFIWKQSTDLTFQYKTKQNFNYDGK
What is the function of this protein?
Regulator of deubiquitinating complexes.  Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity).
What are the official names of this protein?
WD repeat-containing protein 48 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR48 family.
Protein: CA15_CONQU
Sequence: SDGRNAAADDKASDLIGLAVRGCCSNPACSVNHPELCGRRR
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
What are the official names of this protein?
Alpha-conotoxin-like Qc1.5.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ABR2_ASPFU
Sequence: MWYQSASLLGVAAVAQAATVHYSLDLTWETGSPNGVSREMIFVNGQFPGPAIILNEGDEAIIDVTNHLPFNTSIHFHGIEQKNTPWADGVVGLSQWAIQPGQSYTYQWRADTYGTYWYHAHDKAEIMDGLYGPVHIRPRPNRDSPFSMISDDPADIRAMKQAERNGKLVMLSDWDHLTGQEYMKAMEETGYDIFCSDSVLINGRGSVFCHDPEELTQMVPPPELAILNSSLTDKGCLPFVPPIQGNWEHHPDKVPPGLNEGCHPSTTQETIFTVDAAHQWASFHFISAASLKVLVVSIDEHPMYVYEVDGRYIEPQLAHSVKLYNGERYSVMVKLDKEPANYKMRAANDGGNQIVSGFATVTYEGGETSQRPSQPYIDYGSRNTSADVIPLDTNHLPPYPAISPASEPDDFHILMLGRTNSSWEWSLDGAAFLPSNLAALPPAILSPQAPEFADALKITTRNDTWVDIVFQLVVSETTPIQPPHPLHKHSNKGFLLGTGHGKFNWTSIKEAKEASPESFLETPVYRDTFTTSPQGETWTAIRYHVENPGPFLLHCHMTTHLQSGMGLILMDGVDVWPEVYADMITPM
What is the function of this protein?
Laccase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall (PubMed:10515939, PubMed:14970241, PubMed:19156203).  The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA (PubMed:10515939).  The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening (PubMed:10515939).  1,3,6,8-THN is substrate of the hydroxynaphthalene reductase arp2 to yield scytalone (PubMed:10515939).  The scytalone dehydratase arp1 then reduces scytalone to 1,3,8-THN (PubMed:10515939).  1,3,8-THN is also substrate of the hydroxynaphthalene reductase arp2 to yield vermelone (PubMed:10515939).  Vermelone is further converted by the multicopper oxidase abr1 to 1,8-DHN (PubMed:10515939).  Finally the laccase abr2 transforms 1,8-DHN to DHN-melanin (PubMed:10515939).  DHN-melanin biosynthesis appears to be initiated in endosomes where early enzymes (abl1, ayg1, arp1 and arp2) localize, with exocytosis leading to melanin deposition on the cell surface where late enzymes (abr1 and abr2) localize (PubMed:26972005).  DHN-melanin is an important structural component of the outer cell wall and is required for the presence of conidial surface hydrophobins (PubMed:19703288).  DHN-melanin also plays a crucial role in fungal virulence, including a protective role against the host's immune defenses (PubMed:19156203, PubMed:20145078, PubMed:21747802, PubMed:21573171, PubMed:24818666).  DHN-melanin protects also conidia against amoeba predation (PubMed:25684622).
What are the official names of this protein?
Laccase abr2, Conidial pigment biosynthesis oxidase abr2.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Cell surface.
Protein: NU4LM_RHYRA
Sequence: MTTIYLNLILAFTLALSGVLIYRSHLLSTLLCLEGMMLSLFILMALTISHFHMFSLSMAPLILLVFSACEAGVGLALLVKTSNAHGNDHVQSLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FRMD5_HUMAN
Sequence: MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSNERVAVIADEAYSPADSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELRALCQGHSGPEEEQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFRDIRQTPEFEQFHYQYFCPLRRWFACKIRSVVSLLIDT
What is the function of this protein?
May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675).  May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1.  May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).
What are the official names of this protein?
FERM domain-containing protein 5.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cell junction, adherens junction.
Protein: COBS_CLOB6
Sequence: MKSILNDFLLMIQFFTRIPINKNLQCEKVNFRRGAFFLPVVASIIGGMEFLIYLGLKNFLPPNVIIVLLLLFTAMITGGLHMDGLADTCDGFFSLRDKERIIEIMKDSRMGAFGTIAMIINLLLKYQLLYSLVLKDCSIAIILAPVIGRISILFLCLSKRTAKKNGSGNIFIGNMSKPIIFLITIIALAMNTYFLELKITIISFTAVLIITYLFYLLCLNKINGLTGDTLGACNELGEITFLLILLMM
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFTS_LATSS
Sequence: MAEIKAAQVMELRKKTGVGIMDAKKALVASDGNVEEAIDALREKGMAKAAKKNDRIAAEGLAGVAIDGNTAAIVEVNSETDFVASNDQFKALLKDIAETIAKNKPADMAAAEELPMGEGTIASSVINLTAVIGEKISFRRFELVEKNDGDHFGSYLHNGGQIASLVTLEGADDEAAHDVAMHVSAVNPQYVSREDVPAETLDHEREVLTEETKNEGKPENIIPKIVEGRVNKFLSEISLNDQAFIKDSDQTVAQFVASKNGSVKGFVRFTVGEGIEKKENNFVDEVMGQIK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUA1_USTMA
Sequence: MMPISATIDSKSFPFDTTPTYASLDAYQMDQRALPTSPFNGAVKRDQMFDQLLLDPPSPTTSRFDGMWPTSNAQANASSSWTPSAGMPDAFDGVGNSLVNDASSDWSDFLMPLLATVATDFSSGSATKSEPSTCSSSTDFSMSSTADASTAPQHSSSGDSSMSSGLPVSTATCTAMPAAQNHQVTTQDASVQPKLEKQCQPPSHNVNQQNAFASSNQDNNCPQVHIIASWLDQDADRNTGHRQHNRHQKQQNLPQGQSCTNSGSSSRQVTRPNSPNHQRSRPQLRSRSSTGNGYTWPSVDPQVFLWAAFMMNGFQQAQAGTATASPMSDYSAMEYDDEPQAQHGYHATENCNVDDAMDGTGDFCKKEDRSQSADCGLLPRPPSNSPEPHPYPLDPMAAFARAAAESMAMSYSWPMPMPTNMMELQHNPARSNSTFGRVSQRHHQPPPSHRQRSRTSASSISNTNAAHRKHKVDAVRQSAVRSRRQSFVEPRQCASQSPSSPSESTAATDAKLTKPRAQSAGRSHVTERLPHLHTLSYSTPPDTSSSVSALTSTTTTTVSTGASSVASSISGPSSASSGIGNASGSLSFTITDKIVLKPRPGSGDEELAYPCATNSLLEMQNNEGPIVDAQQQAEEAVEKVQNLFPSDLYAPRFTRRGTCGREGWCSLCPQGEWYSMKRSQYLYHMQFDHGISNLTRRLFHPPQTLRVWNDAVSKTDGLCHHCNKWIPICFGPQRKRDFKAWFKHARKCHRDDTGCPI
What is the function of this protein?
Transcription factor; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA) (PubMed:17850255, PubMed:20173069).  UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U. maydis (PubMed:17850255).  Recognizes and binds to the specific 5'-T/G-G/T-C-G-C-A-T-A/T-C/T-C/T-G/A-3' upstream activating sequence found in all promoters of the UA biosynthesis genes (PubMed:20173069).
What are the official names of this protein?
Transcription regulator rua1, Regulator of ustilagic acid production 1, Ustilagic acid biosynthesis cluster protein rua1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS21_MICAN
Sequence: MTQVVVGQNEAIESALRRFKRQVAKAGIYADIKKHQFFETPQEKRKRKAVARRRQRTRRR
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: IVBI5_PSEPO
Sequence: MSSGGLLLLLGLLTLWEGLTPVSSKDRPEFCELPADSGSCKGNFQAFYYHPVHRTCLEFIYGGCEGNANNFKTIDECKRTCAA
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
Blackelin-5.
What are the subcellular locations of this protein?
Secreted.
Protein: DSRB_SALG2
Sequence: MKVNDRVTVKTDGGPRRPGVVLAVEEFSEGTMYLVSLEDYPLGIWFFNESGHQDGIFVEKAEQD
What are the official names of this protein?
Protein DsrB.
What is the protein family that this protein belongs to?
Belongs to the DsrB family.
Protein: PBO4_CAEEL
Sequence: MWIKLLFFFTTLLVSTSGLGDDGITALLDPNSTEFSTVLPSNNSEKFSYMLASVKNMNMTASEFEEFIKVLKHRQSKDHSGEHVGNEHDESHGISVVSWHWDYVKNELVLTLFFIVIGLFKLVYHHTFVTRKILPESCCLIFIGIAIGFFFVGDATHASIKFLEFKSKVFFFYLLPPIILESAYSLKDRAFIENIGTILLYAVVGTILNIVLLAAALLILIWVGIMGKYNLSVMDILTFASLVAAVDPVAVLAVFQEVGVNKMLYFMVFGESLFNDAVTIVCYNLAIEFQTLPDFTWYHGFLGLLSFLCVSIGGLIIGLICGAISSFVTKFTTDVRVVEPVVLFGMAYLAYLGSEMFHFSGIIALIACGLFQTHYACCNISYKSFTSVMYITKVCSTLCESLIFIILGVMLVNEREWFWTDWHPVFSAVSVVLCVVVRFGVTFFLTYFVNQFTGGVRHISFQEQFIMSYGGLRGAVSFSLVFMISANPDVKNTMLGATYAVILFTNIIQGSTIKLFVKWLNIRLAKKEDHFRLFIEFNNGMVQHLSQGIEDLCGDKSLSLINRMSELSKKYVRPLLEKNYTANKAKKEGKLVELNRAVAMREALNNSPSQSSFQRQHTIDEMAESGALPHDLLDEEHQGHHHHGQVHPDNEDADQRANELIKDVSSIRQLMHNPFEDCYLDRNLTHEEEKEQARLKMKKTRAFKFSSVRKTIGFFGKKKSVRRHATQQGILHSAIATIGVQSVDRPSTSTRVSVEDEEQGLTMKEMEEEHPLMTITESEETSF
What is the function of this protein?
Na+/H+ exchanger which mediates the transient acidification of the coelomic space and plays a role in contraction of posterior body muscles during defecation (PubMed:18191228, PubMed:18291648, PubMed:23319594).  Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells (PubMed:25849533).
What are the official names of this protein?
Na(+)/H(+) exchanger protein 7, Na(+)/H(+) antiporter nhx-7, PBoc defective protein pbo-4.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein.
Protein: 3L213_DRYCN
Sequence: MKTLLLTLVVVTIVCLDLAYTRKCYKTHPYKSEPCASGENLCYTKTWCDFRCSQLGKAVELGCAATCPTTKPYEEVTCCSTDDCNRFPNWERPRPRPRGLLSSIMDHP
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Long neurotoxin 13, LNTX-13.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TCMK_STRGA
Sequence: MTRHAEKRVVITGIGVRAPGGAGTAAFWDLLTAGRTATRTISLFDAAPYRSRIAGEIDFDPIGEGLSPRQASTYDRATQLAVVCAREALKDSGLDPAAVNPERIGVSIGTAVGCTTGLDREYARVSEGGSRWLVDHTLAVEQLFDYFVPTSICREVAWEAGAEGPVTVVSTGCTSGLDAVGYGTELIRDGRADVVVCGATDAPISPITVACFDAIKATSANNDDPAHASRPFDRNRDGFVLGEGSAVFVLEELSAARRRGAHAYAEVRGFATRSNAFHMTGLKPDGREMAEAITAALDQARRTGDDLHYINAHGSGTRQNDRHETAAFKRSLGQRAYDVPVSSIKSMIGHSLGAIGSLELAACALAIEHGVIPPTANYEEPDPECDLDYVPNVAREQRVDTVLSVGSGFGGFQSAAVLARPKETRS
What is the function of this protein?
Involved in the biosynthesis of tetracenomycin C (TCM C) (PubMed:7814341, PubMed:9609708).  Part of a type II polyketide synthase (PKS) that catalyzes the synthesis of tetracenomycin F2 (TCM F2), a precursor of TCM C, from malonyl-CoA (PubMed:8248801, PubMed:9609708).  TcmK and TcmL form a heterodimeric alpha-beta complex that catalyzes the condensation reactions between the growing acyl-enzyme chain and the malonyl-CoA extender units (PubMed:9609708).
What are the official names of this protein?
Tetracenomycin polyketide synthase ketoacyl synthase alpha subunit, TCM PKS.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Protein: GLGB_BACC2
Sequence: MSVINCEEVKRDEFHTEKYYESYNIFGAHVVTEDEIQGVRFTVWAPHAKAMSVVGDFNEWDYEQHKMLQVTEEGIWSLFIPHIEEGEIYKYAIETLAGDVILKADPYAIYAEVRPNTASVVFDIKGYEWNDKNWTRKKKKKPIYKEAMTVYELHFGSWKKKEDGTLYSYREMVEELIPYVVEHQFTHIEIMPLVEHPYDRSWGYQGTGYYAATSRFGTPHDLMYFVDECHKYGIGVILDWVPGHFCKDAHGLYLFDGTPTYEYKDKDVQENPVWGTVNFDLGKREVRNFLISNALFWMRYFHIDGFRVDAVANMLYWNKEGQEQSNEHAVSFLRELNEAVFAEDEDFLMTAEDSTAWPLVTTPTYEGGLGFNYKWNMGWMNDVLKYMECAPEYRKHIHEKMTFSLLYAYSENFILPLSHDEVVHGKKSLLNKMPGDYWDKFAQLRLLYGYFFTHPGKKLLFMGGEFGQFDEWKDLEDLDWNLHDFEMHRYMHDYFKELIALYKRSKPLWQLDHSPEGFQWIDANNNEQSIFSFIRQGDKQEDALVVVCNFTKATYENYKVGVPDFEYYNEILNSDAEQYGGSGQVNKKRLKTILEPYHNQAAHVEITIPPFGVSILRPVKTRKGSKKQDGSKTKVRSNVTSRGKR
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: NUOM_BUCAP
Sequence: MLLSLLVIIPFLSGIFSFFSFRFQKNIPRWIALTGMGLTLLTVIRIWFFEDYYTYQIQSYTHLSYQLILPWISSFGIQFHIAVDGFSIVMLFLTLFLGIIAILCSWNEIKKNEGFFYLNIMLVLMGTIGVFIAFDLFLFFFFWEIILIPMYFLISLWNQKKEDKKKCINIANKFFIYTQISGLIMLASILLLVLNYYINNKILTFNYDLLLIQPVDKSIEYIIMLGFFLAFIIKMPIVPFHGWLADFHERSPYCGAVDIIGALLKTAPYGLLRYNKMLFPNATEQFAPIAIFLGFLSMFYGAWVAFSQVNIKRLIAYSSISHMGLMLIAIYGGNEISFQGLIIQILSNSISTSALFILSGQIYKYLKTQDISEMGGLWTNIYWIPGFSLFFALSNLGIPGTGNFIGEFLILFGIFKEHPLVSIISTIGIIFSSIYSLNMIQKIYYGLSKHDFPKFFLNIKEFWISIVLIFALIFLGLIPQKILNISFESIHFIYNFSKRIQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit M, NADH dehydrogenase I subunit M, NDH-1 subunit M.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLGA_DESVM
Sequence: MRREVVFVTSEMYPFSKSGGLGDVLGAQPLALHRMGVPTSVITPFYGRLRTADYGIHLTVSDCHVGYPWDPITCDIYEADYHGMKVYFVHRGEYFDRRYYYNDHKGDYFDNCERFIFFCRAAMALLRRLGTPPAVLHANDWQSGLVPAYLHFWRQTDPFWADTRSVMTIHNLAFQGRFASRLFTGCGLPPQAWTMSGVEFWGDFNLLKAGIAYADMVTTVSPSYAREILGPAYGCGLEGILQVRQHALHGILNGADYGIWNPAQDKFLPCRYGPDDPQGFAGKQRCKAALLDELGLAPELAHRPVLGFIGRLRGQKGIDLLLDIVPRLMERNVGVIILGEGNLAHEARALDLMETYRGRLCAIVGYTEDLAHRIQAGSDIFLMPSRYEPCGLTQMYALRYGTPPVATAVGGLRDTIVPWPSPEATGFTFGRSDPQLFLEAILDAVHYWEHDTEGWRAMMTRAMHQDFSWERAGRSYLNLYRQLGFDFS
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: RLMN_MARN8
Sequence: MTGAAEKVNLLGMPKAKLEAFFETLGEKRFRAQQVLQWMHQRGVDDFDQMTNMSKSLREQLKEVAEIRGPEVVYDETSKDGTRKWVMRMDNGNSVETVLIPDGERGTLCVSSQIGCSLDCTFCSTGKRGFNRNLTAAEIIGQVWVARRAFMPFDPNDRPITNVVMMGMGEPLLNFENVVDAMNLMMEDLAYGISKRRVTLSTSGVVPALDRLGEVTDVSLAISLHAPNDELRNQLVPLNKKYPIAELLAATRRYLSRLPDKRKATIEYTVIEGVNDQPEHARELVVLLKGLPCKINLIPFNPFPESDFRRPSMNATRRFQTVLNEAGYVTTIRTTRGDDIDAACGQLVGRVEDRTRRSQRYIAVQQVNP
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM144_BOVIN
Sequence: MSSNATDLTTGFIASIVAIVLFGSNFVPLKKYETGDGMFLQWVLCAAIWLVALVVNLILHCPKFWPFAMVGGCIWATGNIAVVPIIKTIGLGLGILIWGSFNALTGWASSRFGWFGMDAEEVAKPVLNYIGAGLSVVSAFIFLFIKSEIPNNTYSVDTTPLISEHVINKTQDPDPDCSWVDKLSTAQSHLVGCSLAVISGILYGSTFVPIIYIKDHSKRNDSIYAGASQNDLDYIFAHFSGIFLTSTVYFLAYCVAMKNNPKLHPEAVLPGFLSGVLWAIATCCWFIANRSLSAVVSFPIITAGPGFIATMWGVFMFKEIQGRKNYLLMMLAFCIILTGALCTAFSKI
What are the official names of this protein?
Transmembrane protein 144.
What is the protein family that this protein belongs to?
Belongs to the TMEM144 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PGK_BORBR
Sequence: MSNVNTLSALAKSGALSGKRVFIRADLNVPFDDAGRISEDTRIRASVPGIRLALDAGAAVMVTSHLGRPKEGALTEADSLAPVAQRLSELLGMQVRLVPDWVDGVSVEPGEVVLLENCRGNVGEKKDDEGLSRKMAALCDVYVNDAFGTAHRAEATTHGIARFAPVACAGPLLEAELEALGRALHDPKRSLVAIVGGSKVSTKLSILQSLADKVDQLVVGGGIANTFMLAAGLPIGKSLAEPEQVEQARAVIEIMKRRGAEVPIPTDVVCAKSFGADAAATVKAAADVAEDDMILDIGPQTAQRLADILKAAGTIVWNGPVGVFEFDQFAHGTEVVARAIADSAGFSIAGGGDTLAAIAKYGIADQTGYISTGGGAFLEFLEGKALPAVAVLQARAA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.