PharMolix/UniProtQA huggingface dataset:
Protein: ATOB_ECOLI
Sequence: MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSQHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVCGFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGITAENVAKEYGITREMQDELALHSQRKAAAAIESGAFTAEIVPVNVVTRKKTFVFSQDEFPKANSTAEALGALRPAFDKAGTVTAGNASGINDGAAALVIMEESAALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKALQLAGLQLADIDLIEANEAFAAQFLAVGKNLGFDSEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
What are the official names of this protein?
Acetyl-CoA acetyltransferase, Acetoacetyl-CoA thiolase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAPR_LISMO
Sequence: MKKYSKKDRQMKLQVAIEENPFITDEQLAEKFGVSVQTIRLDRVALSIPELRERIKHVASVNYADAVKSLPIDEVIGEIIDIQLSKSAISIFDVRSEHVFKRNKIARGHHLFAQANSLATAVIPNEIALTTQATVRFVRSVNEGERIIAKAKVRPATDNRAITIVDVKSYVGDEIVLKGKFEMYHATQK
What is the function of this protein?
Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.
What are the official names of this protein?
Transcription factor FapR, Fatty acid and phospholipid biosynthesis regulator.
What is the protein family that this protein belongs to?
Belongs to the FapR family.
Protein: RL6_STUS1
Sequence: MSRVAKNPVKLPAGVEIKMSGQQLSVKGAKGALELNVHPSVEVIQEGGELRFAGRNGDQQTRAMAGTTRALVNNMVIGVSQGFERKLQLVGVGYKAQAKGQVLSLALGFSHPVDYELPQGVTAETPSQTDILIKGVDKQLVGQVAAEIRDFRRPEPYKGKGVRYSDEVVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: VP03_ALHV1
Sequence: MITRELQLLAYTAEPSALETAAIAALRSIPGLQNVIIQTQDAYLVTFFTSPRPLREHQLKIETLLFIKAALRTFDEQQYLPIPLSALSSSFTFVYGPDINRLPTSQSNELTAILQTRDAREKVFNVERIQHCRLLFFSGPGSEQLNHTHYALLREILCGDLTLYQPFRNELFNSSLDFYATIYPPRFLKDKVRHYVHGDINLNITGAASNYNWASPHTAVTDSEIFRIPYTHVVRFIDRWEIRVRVPDVGFHGSRGVRFRQHGGAAYMCSTLNSTTGATGCLQKGMITSFISQPTLGQLGLITEPMCGWGQQELSATAIQMLTKYANTVEAFAKTLNYAGVPLVQGFVTLSPTLREKRAMAFTGSLSITGLPPYILKPPTAETLDAAMERNRQLLLVEVGYPDYGKGKLHNPVNIMNSESGRHAHILHQALRQLMIITPFGKVIHICCDWQYNEKVTMFKIAKACGDLGLSMSARSLPAHTLRLLKKWNFRNLNYNHRIIKNSWLKVDSAAALVVIADNEYQDVSKKMDIALSGWGCPFHILGNLTPNSNTIVISDKNQYGEIVDIQYKMHMPKQPSEGTEDTPLAPDMSNIQLFKNLDVTEDLLLQVLRHPTVGCKAHIVHHVDRCGNGHIAQQPGVGPFDIPLCDFSVTVHNLVDGDIREGMESVPRVWAADWRVARRLIETQYSTPGLDITDATLANNLGLTYHIPSEHQVTVESKKYGNCIGIGEKTTFTQRDPLLGTILAIVESCTNCILGPVENYEEFLIGLSISVPEGIHYRHEVNSIMAMAKDFCSSMNFGFQVNSAENGNCLLRSVVATANAPCVVPGPSLKPYFKKPGSAILRVNLHTEHFLSGGICCMASGIGASETFTPTPSQLRNLLQFMLIVKAENLALSGHDVSDGGLICAVCEMMFAGGLSARLIIHDEDEEPVFPLFSETPGFVLEVNAIDVAAIIARANLYNVECIQIGEVVESDTFTVFHQNTQLLSVPVSRLKHNWTLFSKSVDLLYVKEDQVLPEETSYGNYEVHLTVDPYSIISQSTTRPNVLVHLLPGCGYPDALLAALTNSGFSPDTVVYPGCKYRHNRREDAAPGSPTADDFIAGIVLYGSSNIDSDVGDSTIRQWLNVNRQVINDVRRNLKAKGSFTLAIGQLACRILFATKAIGFDAGSQQTPFLLPNASRRYESRWLNFKIPEDTKAVAFRDLRGCVLPCWVQGTHLGFSHNNITFFGDLETRQQVAATFNGPLVQSGPAREYPLNPTEAEHPYAGLCSEDGRHLALLFDPCLAFNTWQWQHNQTGPGQGELPVSPWKLMFYRLYNWSKFHQHYRSLLRTNLRHTFNFETQQLDFPHADRRGAVPHDNPQYIPMDAMDPSQ
What are the official names of this protein?
Probable tegument protein antigen 3.
What are the subcellular locations of this protein?
Virion tegument.
Protein: GM_BHV1C
Sequence: MAGSAQPAAVHWRLWLAQVGVFAGLALLLLITLIGAASPGAGLPCFYAAIVNYNARNLSADGGAWAQRELGARHPALFLETPTTAAFSAYTAVVLLAVAAFDVAAAIIIRRENSGGFAAAYHMNALATLATPPGALLLGALAAWTLQAAVLLLSHKIMVLAAATYLAHLAPPAAFVGLFCTAGLPGAEYAQAVHALRERSPRAHRLLGPGRAVMINLAGGLLALIIGTAPLMLGQLLGAGLGLSLAQTVVAGVTVFCLAAVLFLVLTELVLSRYTQVLPGPAFGTLVAASCIAVASHDYFHQLRGVVRTQAPRAAARVKLALAGVALLAVAMLVLRLVRACLHHRRKGSAFYGHVSAARQQAARYIARARSSRGMAPLEGDAAALLDRGVASDDEEAVYEAHAPPRPPTIPLRRPEVPHSRASHPRPPPRSPPPAHVK
What is the function of this protein?
Envelope glycoprotein important for virion assembly and egress.  Plays a role in the correct incorporation of gH-gL into virion membrane.  Directs the glycoprotein N (gN) to the host trans-Golgi network.
What are the official names of this protein?
Envelope glycoprotein M, gM.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein M family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
Protein: NADE_SALEP
Sequence: MTLQQEIIQALGAKPHINPEEEIRRSVDFLKAYLETYPFLKSLVLGISGGQDSTLAGKLSQMAIAELREETGDNALQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQALREAGIELSDFVRGNEKARERMKAQYSIAGMTHGVVVGTDHAAEAITGFFTKYGDGGTDINPLHRLNKRQGKQLLAALGCPEHLYKKVPTADLEDDRPSLPDEAALGVTYDNIDDYLEGKTLDPAIAKTIEGWYVKTEHKRRLPITVFDDFWKR
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: TAL_ACTSZ
Sequence: MTTQLDALKQMTVVVADTGDIEAMKLYKPQDATTNPSLILSASALPQYVSLIDDAVAYAKAKSSDKAQQLIDAEDKLAVNIGLEILKLVPGRISTEVDARLSYDIQGTIEKARKIIALYNEAGVANDRILIKVASTWQGIRAAEVLEKEGINCNLTLLFSQAQARACAEAGVYLISPFVGRILDWYKANSDKQEYAPAEDPGVISVTQIYNYYKQYGYKTVVMGASFRNIGEITELAGCDRLTIAPPLLKQLQENEAPLARKLEYKGEVQTRPAPMTEAEFYWEHNADPMAVEKLAEGIRKFAADIEKLEAMLAAKL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYF_PROM9
Sequence: MKDLKNQIMRKTTLFIFSLLFISSILFYPKTTFAYPFWAQQNYESPREATGKIVCANCHLAQMPTIAEVPQSVGADSVFKAVVKIPYKNDLKEIGADGSEVPLQVGAVVMLPDGFKLAPQERWTEEIKEETEGVYFTNYSEEKDNIIIVGPLPGDTNKEIVFPVLSPDPSTNKEYHYGKYSLHIGGNRGRGQVYPTGDKSNNVVFTSSTSGTINSIDTIEDGSYKVNIENENGEITTEAVPVGPQLIVKAQDKINAGDPLTNDPNVGGFGQLDAEVVLQSPYRVIGLIAFFIGVGLTQILLVLKKKQVEKVQAAEGI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: NAGB_RHOOB
Sequence: MEIVIRQTPSEVGTTVADIVEGYVRRGPTTLGLATGSSPLGSYRELARRHRESGLDFSDARAFLLDEYVGLPKSHGQSYFSVIRSEFVDHVNLDPGHVLSPDGESSDIAEEGARYDAAIAEAGGIDVQLLGIGTDGHIGFNEPGSALTSRTRVKTLTEQTRLDNARFFDSVDDVPHHVLTQGLGTISEARHLVMIAFGKGKAEAIAAAAEGPLSAFCPASVMQLHRHVTVVIDEAAASKLQLADYYRYALEHKPSWQSF
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: Y8566_DICDI
Sequence: MAILASICSIGNIKTNSSKLIINNISSQSSNMNYNIIQCNGPMSNSSGCGNSTGPIVGGVIINRGAVSGVLCIVGGVVNGLVGGGCN
What are the official names of this protein?
Putative uncharacterized protein DDB_G0271896.
Protein: SPRT_SERP5
Sequence: MNKARIPIALQQAVMRCLREKLQLARQHFSVEFPEPKILYQQRGTSAGTAWLQAWEIRLNPVLLMENQQPFIDEVVPHELAHLLVFRQFGRVPPHGNEWRWMMESVLQVSASRTHQFEIASVQSKTYPYRCGCQLHQLTVRRHNRVMRGESEYRCRQCGDKLKFFAGEPV
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_RICPU
Sequence: MESFEKLEKLLSYSFKNKELLIEALSHPSLRQHHEYKDDKDYERLEFLGDAVLNLVITEILFRNFANYNEGNLAKIRSYLVCKETICMVGAKLTLKNYIIMTHGEEVAGGRDNLNNIENATEALIAAIYLDSNIETTHDIIEKLWAEFIKVQNLTDYDPKTALQEWAQASDHHLPIYRLIKREGASHASTFTVLVKVKDYEQTGTGHAIKEAEKNAARSLLHRLKND
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMT11_CAEEL
Sequence: MVAVAAFSSSGQDKPAHTPKLGLFVYILAAASVIGGFLFGYDTSVVSAAMLYMPDAPGLKPMDTVWQEVLVSISPGMAAVGSLMSGTSSDYIGRRKVILGASAIFTIGALVCAASVNKIMLLVGRVLLGIAIGFASMIVPVYLGETAPTHVRGMLVAAFALMISFGQVVANITGGAFSYIDPYNVGWRLMFAFAAVPSIIQFVCFMFLPETPRWLYENGFETETREVLEKVYNGDKEWVEYEMAEIIAFNEDQAKENEKAHASGPVIWRILKTPHVLKACFIGSMLQAFQQLAGINTILYYTADIIRSSGISNNHTTIWISVLLSLCNFIGPFVPMSLIEKVGRRIIFLFSCGLVVLSLVFIGVAFLLVNHDSAATLPANQYGSNFNSSYPDAKGCMAYSNCDYCVTTDACGFCHDANTKQGYCLPAGFDNPEVYSSTGSCTNSNGSIANNFKWEKYYCDTKYTLLPIIACGVYLLTFSSGFTSLPWVLNSEFYPMWARSTCVAISTTSNWVFNLIIALTYLSLTQVIGKYGAFWLYAGLTVIAFIFILFLVPETKGYSIEEVEMLFMNKKQRREAESRRRETVTEVRSRMNSTVSFGQHNEVHKY
What is the function of this protein?
H(+)-myo-inositol cotransporter (By similarity).  Probably by promoting the transport of myo-inositol regulates intracellular osmosis in response to hyperosmotic stress (PubMed:21679696).
What are the official names of this protein?
Proton myo-inositol cotransporter hmit-1.1, H(+)-myo-inositol cotransporter hmit-1.1, H(+)-myo-inositol symporter hmit-1.1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the lumenal side of intestinal cells.
Protein: LMPC_DICDI
Sequence: MVANNKGLLIAGLLLSVIGAALFVISLALLPSVLNVATNNAIVDAVIVDSFKSQRYNDWAGQKSVDNYFKQYYYLWNLTNPNEVLNGKNCNFEKIGPFNYKYEWNNSKVSFSDDGNLINYIQSKSYKWIEGEDSLNPFTVSTTNFNPAYLGLLSTLSKNSITLGMTAEDLLYTLASAPQTKQFLEYLSSDNFTMIAYFYNGPKYFNQQYQLLLSTINNNLTTTPTIYFLEQWSNSTIIPTNGNSSLWDNMLISYGLDSPSGISLQSALEILNPMNQYSLLNSTNGISYWINAVFNGPNSNSYQILEQELGINQAQLTLVMIWWLKGFNDQYTMSQLLKQCEIESIELLGVCQFITTIPLGYKSISQFNITNLPWLEPIEIPIAMGTNLTISTNEAQSNLFNDSIDDSLLTIHGLGLFLEQMSTNSNNFTKWNLTNNDAMTMIGYFLSYIPNTTGYSIKSVQSFYNTSGLIVTRTANEWLWDCQDDLLDYLGIDQQCSFQQNNTIFKPSTVYTGKKDLSLTNQYQQFQEQSTLTIWNGTVNVTGFVENGQMAPLVQDNLPQSLTIFEENILRPLSLVHSSSSSVMGVSTQRYYLPNQSFPIDPVFNNSINGFANLTGLFNGVPIYVSLWDMYGVPIEYSSLYINGLNQTYENAEIPLDLEPITGNTLYYNLKLQINLQIPSNANSLWFSSLGNWTNIFSPTNSNSFGIFYPSLKIGQTATASTNDINLLKQQFKQIQTVKIAPVVVVSIFGGILLIAGLVMAINGFRKTFYNNNQYNGYNIIN
What is the function of this protein?
May act as a lysosomal receptor (By similarity).  May be involved role in macropinocytosis and fluid phase exocytosis.
What are the official names of this protein?
Lysosome membrane protein 2-C, Lysosome membrane protein II-3, LIMP II-3.
What is the protein family that this protein belongs to?
Belongs to the CD36 family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Note=Localizes to membranes of endolysosomal vesicles and macropinosomes.
Protein: UBIB_PARXL
Sequence: MRFLRFLKIFFTVIRFGLDEMMLSRVNDRRVRLLLRITTIGRKFDAPPGVRLRLALESLGPIFVKFGQVLSTRRDLLPVDIANELAKLQDQVPPFDSAVAIGLVEKSLGAPVDVLFDDFERVPVASASIAQVHFATVKAGQHAGKAVAVKVLRPNMLPVIDSDLALLRDIAVWAERLWADGKRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMYWEFCTPTVLVMERMVGVPISQVETLRAAGVDIPKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPAHFGRYIALDFGIIGALSDFDKNYLAQNFLAFFKRDYHRVATLHLESGWVPPTTRVEELESAIRAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLVLLQKTMLNVEGLGRSLDPELDLWKTAKPYLERWMNEQIGLRGWYERLKIEAPQWSKTLPQLPRLIHHALAERHDHTRGANDEMIRQILLEQKRTNRLLQGLLLFGVAVGVGAALARVFLALAYGG
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: IRS1_HCMVA
Sequence: MAQRNGMSPRPPPLGRGRGAGGPSGVGSSPPSSCVPMGAPSTAGTGASAAATTTPGHGVHRVEPRGPPGAPPSSGNNSNFWHGPERLLLSQIPVERQALTELEYQAMGAVWRAAFLANSTGRAMRKWSQRDAGTLLPLGRPYGFYARVTPRSQMNGVGATDLRQLSPRDAWIVLVATVVHEVDPAADPTVGDKAGHPEGLCAQDGLYLALGAGFRVFVYDLANNTLILAARDADEWFRHGAGEVVRLYRCNRLGVGTPRATLLPQPALRQTLLRAEEATALGRELRRRWAGTTVALQTPGRRLQPMVLLGAWQELAQYEPFASAPHPASLLTAVRRHLNQRLCCGWLALGAVLPARWLGCAAGPATGTAAGTTSPPAASGTETEAAGGDAPCAIAGAVGSAVPVPPQPYGAAGGGAICVPNADAHAVVGADAAAAAAPTVMVGSTAMAGPAASGTVPRAMLVVLLDELGAVFGYCPLDGHVYPLAAELSHFLRAGVLGALALGRESAPAAEAARRLLPELDREQWERPRWDALHLHPRAALWAREPHGQWEFMFREQRGDPINDPLAFRLSDARTLGLDLTTVMTERQSQLPEKYIGFYQIRKPPWLMEQPPPPSRQTKPDAATMPPPLSAQASVSYALRYDDESWRPLSTVDDHKAWLDLDESHWVLGDSRPDDIKQRRLLKATQRRGAEIDRPMPVVPEECYDQRFTTEGHQVIPLCASEPEDDDEDPTYDELPSRPPQKHKPPDKPPRLCKTGPGPPPLPPKQRHGSTDGKVSAPRQSEHHKRQTRPPRPPPPKFGDRTAAHLSQNMRDMYLDMCTSSGHRPRPPAPPRPKKCQTHAPHHVHH
What is the function of this protein?
Inhibits the establishment of the antiviral state in the infected cell.  Prevents the phosphorylation of the host eukaryotic translation initiation factor eIF-2alpha and thus the shutoff of viral and cellular protein synthesis by directly interacting with EIF2AK2/PKR.  May also participate in viral DNA replication by interacting with the DNA polymerase accessory protein and the lytic origin of replication, oriLyt.
What are the official names of this protein?
Protein IRS1, HQRF1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae US22 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus. Note=Isoform IRS1-263 is predominantly nuclear.
Protein: THIE_METVS
Sequence: MTFKNKLKFYVITDRKYSCEVYSVEQALKGGATAVQLRMKSSNTREMVEVGQKIRKLTLEYDALFFVNDRLDIAQAVKSDGIHVGIDDISISKIKEIAPELIIGASAYNINEMKIAESEGADYLGVGSVYPTNTKLDARYLGLNGLKELSNCSNLPVVAIGGINHENVKEVLMCGVSGVAVVSAIVGANDIIFSAKKMNEIIKKYI
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: YQGF_ECOUT
Sequence: MSGTLLAFDFGTKSIGVAVGQRITGTARPLPAIKAQDGTPDWNIIERLLKEWQPDEIIVGLPLNMDGTEQPLTARARKFANRIHGRFGVEVKLHDERLSTVEARSGLFEQGGYRALNKGKVDSASAVIILESYFEQGY
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYAS2_HUMAN
Sequence: MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV
What is the function of this protein?
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (PubMed:20507985, PubMed:32993960, PubMed:23303191, PubMed:21228273) (Probable).  Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (PubMed:8798477, PubMed:21228273, PubMed:20507985).  This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity).
What are the official names of this protein?
Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2.
What is the protein family that this protein belongs to?
Belongs to the NodC/HAS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi- pass membrane protein. Vesicle. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane and either back to endosomes and lysosomes, or out into extracellular vesicles (PubMed:30394292). Post-translational modifications control HAS2 trafficking (PubMed:30394292).
Protein: TBP_THEVO
Sequence: MSEREKITIENIVASTSLAEHLDLSRIALALDGSEYEPEQFPGLIYRLQDPKTAVLIFRSGKVNCTGAKNIEDVKRTIKIIIDKLKAANIEVYDDPDIIVQNIVAVYDLESELNLTDIAMSLGLENVEYEPEQFPGLVYRVEEPRVVLLLFGSGKVVCTGAKEESEIEQAVIKVKKELQKVGLI
What is the function of this protein?
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
What are the official names of this protein?
TATA-box-binding protein, Box A-binding protein, BAP, TATA sequence-binding protein, TBP, TATA-box factor.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
Protein: TLH2_SCHPO
Sequence: MVVASEIAKVASKTARDIAGCFTCQCGTQFDNVERIVQHFKECRYRDETCKDDDIVVYEPSSFVQDEKKDKPIIVEAASEATSEEACNSSKERQLPALSALSALSTLTTSANDDLWTARLIWQSTNDTKLDNSPSSNYTDLNHKLANYGLSILSIHALMCVECECLLNVIHTAQHMQIVHKLELNEDLLWFQELRTLKLKSPTNVLQTHSSQTHVYPYIRGLPVLLNGYECVPCTKNGTGFVHAIMDTFRHHVRRTHGKVIKLENCIRRTALQTVKNKYAQRCQFFKVDYVPLNGGEEEEEEEGEEKEDAQNIKERMVDFCFSKFMEKNQQRREQQDKGENKKRQDDVDQATDNNTNTILEDDEKDNDEEEEEEIVNAREKNLLNQQFNWTAIVKKLGENWDQLVRFEYTNGIVTLDTIVNQLIRYYYRGFRHLSGMTMGMRRMFTQGGSYSAQERGLCRLEQKDTVVRYAQSAALYLIFLLRRPSADSGIRRHLEAMCGATVERKEGGSNSSSNISNVANFDSAEDDNDNDNDNDRDSNNNNNNNNTNTDDDDKLAYLELHEALKLAFLQQYDFSKNVQDLEIMEFLACMSLHKDGTSKYAYEISACFAPLIYTCRLVAACELQRLIDEKQIDLLSIPSFQTAGSIAYAHVFCFITLGQRNLYDVLYETQKVVRDIIRTEGYANTLQGLSPSTVLFQPRSNSMYPCIGDAFNNMVRLDLSELTALYEGMFAKVQDLLKELCFDMNVEKLLPISLLRSIGDDINNSKLGYSFFKESIEIRSSHSVLLRTILKNSELCHRFFPSMSKKDLTKLFGGVSDQQRNECDNYSNHYNDNSNDNDNDVFLKLHWSKSAIKKYETKASIFNELLFCLVYISAGQPARAQEMVYWTLRNGKYKTRELYLMFGRLMIYSRYDKTRNMKFAEKPIPRFLSEPLSILALRYYVLVRPLEALMKYVTTADRSKVAVYLDFMFVIAGERLQRDLPYRIFPKATYQCIQKPLGFRNYRHIAHYFKEKNIEEEMTRESYFDLQAGHTRNTALYIYGRTMDNLHYLPSDYFANFFRASYKWQELLQIRDNPTHGLLVETKHPFIKRVDQLEEALNEKLARLVGEQMVEGDKEKDKTNEEKNKDEVKAEMTQPVVNQDSHDLQDQLATTPTAPTAFHYRPGLLQPSQTSVQHCCWALSQYYGLEAKFRSLKQFQSVYFSLLNRMNLITVLPTGGGKSLSFLIPALIEKKRQTPGKVMNMVTLVLVPMMSLRQDMMLRVNEKGLLVCSGNWTAFKDVRLTLETQLPDLFILTYESALTNSGLRFFESLATLGRLARVVIDEAHLLLTSGAWRTALSRASRLSGLYAPLHLLSATFPRQLEMVARQTFCTNFYVLRETSTARENIFYFLHPYDNTEFLLDLRTLMKRTKVFEGDGRAIIFCRTKKDVEYIHRRLHQSDLFAHTHVTIYTGDVSDEERQMNFDAFRNANGKTRIMIATKAFGLGINYMGVRLVVHYGLPASSMDYVQETGRAGRDGKYAIAALFYEKYDSTWSSYVEDSMKNFLNDNTMCVRSFLASEMDGECVCCASFANCVYCSRCSDSLLGEESTVSTMYGVKPTLPETPKPAIATHSRYNASFSSSPPPQPGNSSGMSAMNTNTTSTTPVSLSELSEITLFPSSVSPTWKKSFGNANTNLKYGLEDMSLSHRRGHKRTYDEHLNNVQQGVNHDMNRVHGSVGGMSGIVGIGIGIGDGDGDGDVDSRTIHFAEYKSRVQAVKKQWVDSTDISAQLERFFRVYKDECLSCTLGNPDTEIRAHTGKACPVRLSTCYKCGKADHNLRECKLRIRFQGLCLFCGLTKFEHADSDMAYTSDCRSWARKANLISLVYYAWNNVQYRRTIADKFLQGDVRDQAFYGFVCCSTTTNSAFVLVIHYLLSDVLQIM
What is the function of this protein?
Exhibits ATP-dependent 3' to 5' DNA helicase activity and has a role in telomerase-independent telomere maintenance.  Represses ade6 at an ectopic site.
What are the official names of this protein?
ATP-dependent DNA helicase tlh2, Sub-telomeric helicase RecQ homolog 2.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
Protein: SESQ1_MOUSE
Sequence: MKLNERSLAFYATCDAPVDNAGFLYKRGGRGTGSHRRWFVLRGNILFYFEAEGSREPLGVILLEGCTVELVDAREEFAFAVRFAGGRSRPYVLAADSQAALEGWVKALSRASFHYLRLVVRELEQQLAAMREGSPANALPANPSPVLTQRPKENGWVVWSTLPEQPSVAPQRPPPLPPRRRASAANGPLASFAQLHARYGLEVQALRDQWRGGQAGLASLEVPWHPGSAETQTQDQPALRGHSGCKVLHVFRSVEWPVCNPGSQGT
What is the function of this protein?
Plays a role in endocytic trafficking.  Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
What are the official names of this protein?
Sesquipedalian-1, Ses1, 27 kDa inositol polyphosphate phosphatase interacting protein A, IPIP27A, PH domain-containing endocytic trafficking adaptor 1.
What is the protein family that this protein belongs to?
Belongs to the sesquipedalian family.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.
Protein: CLPP_NEIMA
Sequence: MSFDNYLVPTVIEQSGRGERAFDIYSRLLKERIVFLVGPVTDESANLVVAQLLFLESENPDKDIFFYINSPGGSVTAGMSIYDTMNFIKPDVSTLCLGQAASMGAFLLSAGEKGKRFALPNSRIMIHQPLISGGLGGQASDIEIHARELLKIKEKLNRLMAKHCGRDLADLERDTDRDNFMSAEEAKEYGLIDQVLENRASLQL
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YRDC_MOUSE
Sequence: MSTARPCAGLRAAVAAGMGLSDGPASSGRGCRLLRPPEPAPALPGARLLRLPESEPVEAASPERSGWTEALRAAVAELRAGAVVAVPTDTLYGLACSASSSAALSCVYRLKGRSEAKPLAVCLGRVADVYRYCQVRVPRELLEDLFPGPVTLVMERSEELNKDLNPFTRLVGIRIPDHAFMLDLAQMFGGPLALTSANLSSQASSLSVEEFQDLWPHLSLVIDGGPIGDSQSPECRLGSTVVDLSVPGKFGIIRPGCALENTTSILQQKYGLLPSQGSCS
What is the function of this protein?
Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.  Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (By similarity).  May regulate the activity of some transporters (PubMed:16024787).
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, Ischemia/reperfusion-inducible protein, mIRIP.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Cell membrane; Peripheral membrane protein. Note=A large fraction localizes in the cytoplasm, whereas a smaller fraction is imported to mitochondria.