PharMolix/UniProtQA huggingface dataset:
Protein: RPAP2_PONAB
Sequence: MADCAGPSSAGRKAGAPRRSRKAAGTKQTSTLKQEDASKRKAELEAAVRKKIEFERKALHIVEQLLEENITEEFLMECGKFITPAHYSDVVDERSIVKLCGYPLCQKKLGIVPKQKYKISTKTNKVYDITERKSFCSNFCYQASKFFEAQIPKTPVWVREEERHPDFQLLKEQQSGHSGEEVQLCSKAIKTSDIDNPSHFEKQYESSSSSTHSDSSSDNEQDFVSSILPGNRPNSTSIRPQLHQKSIMKKKAGHKANSKHKDKEQTVIDVTEQLGDCKLDSQEKDATCELPLQKVNTQSSSNSTLPERLKASENSESEYSRSEITLVGISKKSAEHFKRKFAKSNQVSRSVSSSVQVCPEVGKRNLLKILKETLIEWKTEETLRFLYGQNYASVCLKPEASLVKEELDEDDIISDPDSHFPAWRESQNSLDESLPFRGSGTAIKPLPSYENLKKETEKLNLRIREFYRGRYVLDEETTKSQDSEEHDSTFPLIDSSSQNQIRKRIVLEKLSKVLPGLLVPLQITLGDIYTQLKNLVRTFRLTNRNIIHKPAEWTLIAMVLLSLLTPILGIQKHSQEGMVFTRFLDTLLEELHLKNEDLESLTIVFRTSCLPE
What is the function of this protein?
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes.  Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).  Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity).
What are the official names of this protein?
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2, RNA polymerase II-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the RPAP2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.
Protein: AROC_STAAW
Sequence: MRYLTSGESHGPQLTVIVEGIPANLEIKVEDINKEMFKRQGGYGRGRRMQIEKDTVEIVSGVRNGYTLGSPITMVVTNDDFTHWRKIMGAAPISEEERENMKRTITKPRPGHADLVGGMKYNHRDLRNVLERSSARETAARVAVGALCKVLLQQLDIDIYSRVVEIGGIKDKDFYDSKTFKANLDRNDVRVIDDSIAQAMRDKIDEAKNDGDSIGGVVQVVVENMPVGVGSYVHYDRKLDGRIAQGVVSINAFKGVSFGEGFKAAEKPGSEIQDEILYNTELGYYRGSNHLGGLEGGMSNGMPIIVNGVMKPIPTLYKPLNSVDINTKEDFKATIERSDSCAVPAASIVCEHVVAFEIAKALLEEFQSNHIEQLKQQIIERRQLNIEF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RS10B_BOVIN
Sequence: MVKEKKKADKKGDKSARSPSSPSDYPEFAKQDGNAPRQDASPSAAPALDVQPKDPGVKREVKSESLPNEDTTQYEEPVLTKLIVESYEGEKVRGLYEGEGFAIFQGGCTYQGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGIFTWPDGSTYEGEVVGGMRHGFGMFKCSTQPVSYIGHWCHGKRHGKGSIYYNQEGTSWYEGDWIHNIRKGWGIRCYKSGNIYEGQWENNVRHGEGRMRWLTTNEEYTGQWKHGVQNGLGTHTWFLKRIPYSQYPLRNEYVGEFVNGYRHGHGKFYYASGAMYEGEWVSNKKHGMGRLTFKNGRVYDGPFSKDHMVAFPNLEGEVMSYPDSTSECAFGCQWCRPSASAEIMRKLDGNESNSLLGSSLELDLSLLLKMYPERDQSEEKKQVEYAILRNITELRRIYNFYSSLGCDRSLDNTFLMTKLHFWRFLKDCKFHHHNITLADMDRVLGANNDIPVEEIHSPFTTLLLRTFLNYLLQLAYHIHHKEYQDRSPSLFLCFKKLMNENIRPNACRVKGRLFCEAQRTLYSMTYVDKCWEIYTAHCRPNAAPPHELTMSTRHFLWMLRSFKIINKELTATKFVEVIAEDNPSMYDGIDSNFELELVFLEFFEALLSFALICVPEPPTKFCSDFPNDDLSVNKAGSTYPVTAQNTQNRSPSAVASQESDIQFSSTKSSSSKLGVLVDISKIRKSEPKIKKSVSDGTTSKVNFKSAGKGLTFLLSQSAHKHEETLKEKVKENRLHNEAMALQRKMENEELEARLNSLREEEAKRQDYEVDITVIKEPVDAPSSSFTPSPPKEDTVVSSKSITSKKKKK
What is the function of this protein?
May function as part of the axonemal radial spoke complex 3 (RS3).  Radial spoke complexes are important for ciliary motility.
What are the official names of this protein?
Radial spoke head 10 homolog B.
Protein: VPB28_MYCTU
Sequence: MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLPA
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Upon expression in M. smegmatis neutralizes the effect of cognate toxin VapC28.
What are the official names of this protein?
Antitoxin VapB28.
Protein: EFTU_DESVH
Sequence: MGKEKFERKKPHVNIGTIGHIDHGKTTLTAAITKTAGLLGQGKFIAYDEIDKAPEEKERGITIATAHVEYETATRHYAHVDCPGHADYIKNMITGAAQMDGAIIVVAATDGPMPQTREHILLARQVGVPYIVVFLNKCDMVDDEELLELVELEVRELLTSYGFPGDDVPVVRGSALKALESDDPNSDACKPIRELLAACDSYIPEPQRDIDKPFLMPIEDVFSISGRGTVVTGRVERGVIKVGEEVEIVGIKDTTKSTCTGVEMFRKLLDQGQAGDNIGALLRGVKRDDVERGQVLAAPKSITPHRKFKAEVYVLSKEEGGRHTPFFSGYRPQFYFRTTDITGVITLEEGVEMVMPGDNATFNVELIAPIAMELGLRFAIREGGRTVGAGVVSEIVE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_BORA1
Sequence: MAKKIVGFIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAKTQGMEPGLPIPVVITAFADKSFTFIMKTPPATVLIKKAAGVQKGSPKPHTDKVGTLTRAQAEEIAKTKQPDLTAADLDAAVRTIAGSARSMGITVEGI
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PURT_SODGM
Sequence: MITIGTALRPAATRVMLLGAGELGKEVAIECQRLGIEVIAVGHYADAPAMHIAHRHHVINMLDGAALRAVIEHERPHFIVPEIEAIATDMLVTLEQEGHHVVPCANATRLTMNREGIRRLAAETLSLPTSRYRFAADRAELDKAVEAIGYPFIIKPVMSSSGKGQSLVRDAAQLDAAWQYAQLGGRAGGGKVIVEGLVAFDFEITLLTINAVDGIHFCAPIGHRQEDGDYRESWQPQHMSALARQRAQTIAADVVTALGGKGLFGVELFICGDDVIFSEVSPRPHDTGMVTLISQDLSEFALHVRAFLGLPIGTIRQYGPAASAVILPELQSDNVSFSGLENALAAGQQIRLFGKPDLSGKRRLGVALAVAATVEEAVTVAKDAAAAVRVTG
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: TTCA_SALEP
Sequence: MQEIQKNTKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIVRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTALEALRLDVIEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_VARPS
Sequence: MKTTTAQPSPSTSDFSGHTPMMAQYLGLKANHPDTLLFYRMGDFYELFWADAEKAARLLDITLTQRGQSAGQPVVMCGVPFHAVDTYLARLIKLGESVAICEQVGEVGASKGPVERKVVRVVTPGTLTDSELLNDKSESLLLAVHAGTRNFCGLAWLSVTGAELRLAECPADALEAWIARIAPSELLYSAEVTPAFEQRLKAARAATPFTLSIRPAWQFDGGLGERKLSEQMGSNSLAAWNAESLANAHAAAAALLGYAEHTQGRALSHVQRLSVERDGDLVELPPTTRRNLELVQTLRGEDSPTLFSLLDTCMTGMGSRLLKRWLLSPRRDRGEAQARLEAIAALQSTVLGGTAAPWRTLREQLKNTSDVERIAARIALRQVRPRELLALRLALAKAEQLAPALPASGELLGGIIERLAPPSGCADLLASAIKPDPSALVRDGGVIATGHDAELDELRAISENCDDFLLKLEVSERERTGISNLRVQFNRVHGFYIEVTQSALSKVPDNYRRRQTLKNAERFITPELKAFEDKALSAQDRALAREKWLYEQLLDALQPSVPALTQLAGAIATLDALCALAERSHTLHWRAPSFVSHPCIEIQQGRHPVVEARLAEKSSGGFIANDTQLGPQQRMQVITGPNMGGKSTYMRQVAIIVLLASIGSHVPAAACRLGPIDAIHTRIGAADDLANAQSTFMLEMTEAAQILHSATAQSLVLMDEIGRGTSTFDGLALAAGIAAQLHDRSKAFTLFATHYFELTEFPATHHCAVNMHVSATEAGRDIVFLHEMQPGPASKSYGIQVARLAGMPAAVVNHARQALEALESQHAQTRAQVDLFAPPPAAETPMASAVESALAALDPDAMTPREALDALYALQKLNTRERGAA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RL21_RHIL3
Sequence: MFAVIKTGGKQYRVAANDVLTIEKLEATAGDSIEFTEVLVIGEGADAAIGAPFVTGASVKAEVVEQNRGKKVIAFKKRRRQNSKRSRGHRQHHTVVRITDIVAAK
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: LEXA_CORGL
Sequence: MPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIGDAAGLQSTSSVAYQLKELEKKGFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQAGVHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPAEIVGDGDLFMLQVVGESMRDAGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENAEIMGKVVSVMRKL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RL5_STAA2
Sequence: MNRLKEKFNTEVTENLMKKFNYSSVMEVPKIDKIVVNMGVGDAVQNSKVLDNAVEELELITGQKPLVTKAKKSIATFRLREGMPIGAKVTLRGERMYEFLDKLISVSLPRVRDFQGVSKKAFDGRGNYTLGVKEQLIFPEIDYDKVSKVRGMDIVIVTTANTDEEARELLANFGMPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: HTPX_KOCRD
Sequence: MHRHYNGLKTVLLLGGMWVVLLAIGWAIAGATRNSAFIMIFAVVGLLGTAYSYWNSDKLAIRSMRAVPVTPQQAPAMYRIVHELSQAAGQPMPRLFIAPTMSPNAFATGRNPEHAAVCCTEGILQLLDERELRGVLGHELMHVYNRDILTSSVAAAVAGIITSAAQMLQFAAIFGGGRGNDNRGGNPLVGLLLALLAPLAATVIQLAISRTREYDADEDGSKLTGDPLALASALRKIEGGASQFPMDPEDQKVVNTSHLMIANPFRGGAVTGLFRTHPATADRIARLENMARAGGGNPAGR
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HMDH1_ORYSI
Sequence: MDVRRGGGGGRIVGAARRALTWGALPLPMRITNGLAMVSLVLSSCDLLRLCSDRERPLGGREFATVVCQLASVVYLLSLFAHPDAPATTTGDDDDGQGGSRRARPAAAEPAPMHGHGGGMMEADDEEIVAAVASGALPSHRLESRLGDCRRAARLRREALRRVTGRGVEGLPFDGMDYQAILGQCCEMPVGYVQLPVGVAGPLLLDGREYHVPMATTEGCLVASVNRGCRAISASGGAFSVLLRDAMSRAPAVKLPSAMRAAELKAFAEAPANFELLAAVFNRSSRFGRLQDIRCALAGRNLYMRFSCITGDAMGMNMVSKGVENVLGYLQNVFPDMDVISVSGNYCSDKKPTAVNWIEGRGKSVVCEAIIKGDVVQKVLKTTVEKLVELNIIKNLAGSAVAGALGGFNAHASNIVTALFIATGQDPAQNVESSQCITMLEEVDDGDDLHISVTMPSIEVGTIGGGTCLASQAACLNLLGVKGSNHGSPGANAKRLATIVAGSVLAGELSLLAALASGHLVKSHMMYNRSSKDVAKAAS
What is the function of this protein?
Catalyzes the synthesis of mevalonate.  The specific precursor of all isoprenoid compounds present in plants.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1, HMG-CoA reductase 1.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MMS2_SCHPO
Sequence: MAKVPRNFKLLEELEKGEKGLGESSCSYGLTNADDITLSDWNATILGPAHSVHENRIYSLKIHCDANYPDAPPIVTFVSRINLPGVDGETGKVNPHKIDCLRHWKREYSMETVLLDLKKEMASSSNRKLPQPPEGSTFF
What is the function of this protein?
Has a role in the DNA error-free postreplication repair (PRR) pathway.  Lacks catalytic activity by itself.  The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.
What are the official names of this protein?
Ubiquitin-conjugating enzyme spm2, Ubiquitin-conjugating enzyme variant MMS2 homolog, UEV MMS2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: STF3_MYCBO
Sequence: MKALRSSSRLSRWREWAAPLWVGCNFSAWMRLLIRNRFAVHHSRWHFAVLYTFLSMVNSCLGLWQKIVFGRRVAETVIADPPIFIVGHWRTGTTLLHELLVVDDRHTGPTGYECLAPHHFLLTEWFAPYVEFLVSKHRAMDNMDLSLHHPQEDEFVWCMQGLPSPYLTIAFPNRPPQYEEYLDLEQVAPRELEIWKRTLFRFVQQVYFRRRKTVILKNPTHSFRIKVLLEVFPQAKFIHIVRDPYVVYPSTIHLHKALYRIHGLQQPTFDGLDDKVVSTYVDLYRKLDEGRELVDPTRFYELRYEDLIGDPEGQLRRLYQHLGLGDFECYLPRLRQYLADHADYKTNSYQLTVEQRAIVDEHWGEIIDRYGYDRHTPEPARLRPAVGG
What is the function of this protein?
Involved in the biosynthesis of sulfomenaquinone (SMK, initially named S881 on the basis of its mass), which is localized in the outer envelope of M. bovis and negatively regulates its virulence.  Catalyzes the transfer of a sulfonate group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to omega-hydroxy-beta-dihydromenaquinone-9, generating omega-sulfo-beta-dihydromenaquinone-9 (sulfomenaquinone).
What are the official names of this protein?
Omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase Stf3, PAPS-dependent sulfotransferase Stf3.
What is the protein family that this protein belongs to?
Belongs to the Stf3 family.
Protein: SSRP_PSEAB
Sequence: MAKQKKHPSGTIAQNKKALHDYFIEQRFEAGVALAGWEVKSLRAGKAQLVDSYVLLKDGEAWLLGSHITPLTTASTHVIADPVRTRKLLLHKRELGKLFGAVQQKGYACVALSMYWKKHLVKCEIALAKGKKDFDKRHTEKERDSDREIQRAMRHGKDD
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SDS24_CANAL
Sequence: MVNPPQPRQMPKSPRLSTSTSSGPSAVPNLLGSPRPSPPQLQHQPSSASTSSTTSTATTGGSISATAPGSTQHYLHHHPSRKTSIVEILSSPPPLPTDPNDPIHQLSLSRHASTSSNKSSSQSIAPGSTAITNHAFSLVDWSEIPLTELTESNKLISIHSSHSVQSAFETLLKNNLTSVPVSISKSDPHDLTNCLTFDYSDLNTYLLLIMNKINYSELNVDDIGDPNISPQERHEFVTQTISKAKRGEEVPVEFIIKLHPKNPFIKFNETDTLFSVMETLGNGVHRIAITNEEGNKITGILSQRRLIKYMWENARRFPSLDFYLTSTLQDLKIGSSNPITIYEDQMLIEALHKMFNERVSSLAVIDRSRTLIGNISIVDVKNVTSSKNSHLLFKSVLNFISYNLSQKGIEEGQDQFPIFHVNNQTSLGRVIAKLVATQSHRLWIVDSSRQASSMSSASASAPNSGMNNGVTVGYPAPADSSITDKAEEVEASSMSSPQLNAAAAAAAAVATGAPTTATSAQPDFSYTSGTGKLVGVVTLTDILGLFATSKGRRTDPQAARNQRRRSSTSTTRSSIDSALSAEGILPSGSAIIGSSNAANTGRRGSVEVSSDVFRKSYTKAQENAFSKE
What is the function of this protein?
Involved in DNA replication and cell separation.
What are the official names of this protein?
Protein SDS23.
What is the protein family that this protein belongs to?
Belongs to the SDS23 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LPXA_PSEP1
Sequence: MNSIDPRAIIDPSAKLADGVEVGPWSIVGPDVEIGEGTVIGPHVVLKGPTRIGKHNRIFQFSSIGEDTPDLKYKGEPTRLVIGDHNVIREGVTIHRGTVQDRAETTVGDHNLIMAYAHIGHDSVIGNHCILVNNTALAGHVHVGDWAILSGYTLVHQYCHIGAHAFSGMGTAIGKDVPAFVTVFGSPAEARSMNFEGMRRRGFSDEVIHVLRRCYKIVYRQGLTVEDALKELAEPATQHPEVELFRQSILSSARGITR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1324_LISMF
Sequence: MWIYILVGIICLLAGLAGGFFIARRYMMSYLKNNPPINEQMLQMMMAQMGQKPSQKKINQMMSAMNKQQEKEKPKKTKK
What are the official names of this protein?
UPF0154 protein LMOf2365_1324.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SYGA_ECOSM
Sequence: MQKFDTRTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTCLRALGPEPMAAAYVQPSRRPTDGRYGENPNRLQHYYQFQVVIKPSPDNIQELYLGSLKELGMDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLVWSDGPLGKTTYGDVFHQNEVEQSTYNFEYADVDFLFTCFEQYEKEAQQLLALENPLPLPAYERILKAAHSFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCNKDK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_DEIDV
Sequence: MKCPYCSAPDSKVVNSRPSDDGASIRRRRECLNCARRFTTYERAQLEPLMVVKRSGPREAFNPDKLLRGLTLATEKRPVDADALRAFAYGFEDDVQASEIHSEEIGKRAMTFLRPLDDVAYIRFASVYRDFDSLERFIEEIRGLKDQS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RECX_STAAR
Sequence: MPKITKIEVQKKNKERFNLFLDEQFEMGIDIDTLVKFNLKKGQQLEAADMAEIQKYDHYRIGLNKAIQYLSYKKRTEKEVIQYLQKEEISEQAISEVIEYCYREKLIDHQDYAESLKNTMIRTTDKGPKIYQQKLYQLGIEPNIIEMFTELYREQQELDDIIQIAEKISKTKKGPQNKVKEKVMQSLIQKGFEMETIHAVLNEMDFTQDEAVLDDLLQRDLEKIYNKNRKKYTQQKLISKTIEGLMRKGYKYDKIKAKLEESGIADGTEEIE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX5A_NOTPR
Sequence: MLAAALRRCXASVRVLLPKPGAAAPSSWSSSAFRATAAIQSVRCYSHGSHETDEEFDARWVTYFSKPDLDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLDDFASAVRILEVVKDKAGPHKEIYPYIIQELRPTLDELGISTPEELGLDKP
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5A, mitochondrial, Cytochrome c oxidase polypeptide Va.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5A family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: TRP3_ONCFA
Sequence: APSSGFFGTR
What are the official names of this protein?
Tachykinin-related peptide 3, TKRP-3.
What are the subcellular locations of this protein?
Secreted.
Protein: RN169_MOUSE
Sequence: MAAAGPSTRASSAAAAAALSRRGRRGRCDEMAAAKAGAPGPASSPALLVLRSAPRPEESGCTGCLETPGEVAALPCSHSRCRGCASRAAGPGCRRCRPRGSGWARRRARDDGQAAAELMGERARRGQPEPCRPRRDGGAAASGPRPEPEPLAEPEFIFRTPIKLSKPGELSEEYGCLRKLRGEKLQEEKDCDDQIHKLLQEDSEMGKRKADEQKKRDEAVVLKTSLEQCPARLSDSENEEPSRGQMMQTHRSAFVSKNSSCSLAFLAGKLNTKVQRSQSCSDTVQDRVRSRLRTAPPNRAKITTITPGSTPIIGVLLSTQNNRCLSAPDLTIEKRLPFGSLSSLASLHKPERSISPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLTRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEAGEEFPGSDTIHSSKERPSLAFNTRLSRVQVLSECAGPTSTALECFPSVNQTKVEQDCVRKRSREFSLETCHSSEHGGASSGPSLEREQCEESGSTVDATLVKTCISTVMKTAAVNSLLPKNDVLGGVLKTKQQLKTLNHFDLGNGILVNSLGEEPIPSLRRGRKRRCKTKHLEQNGVKKLRPPSSDMDLAPKDPGLLEVGRKLQQEEEDQQLALQSHRMFDSERRTMSRRKGSVDQYLLRSSSLAGAK
What is the function of this protein?
Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage.  Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization.  Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1.  E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF169, RING finger protein 169, RING-type E3 ubiquitin transferase RNF169.
What is the protein family that this protein belongs to?
Belongs to the RNF169 family.
What are the subcellular locations of this protein?
Chromosome. Nucleus, nucleoplasm. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products.