PharMolix/UniProtQA huggingface dataset:
Protein: RS8_RHOJR
Sequence: MTMTDPIADFLTRLRNANTAYHDEVKLPHSKIKANIAEILKREGYIADYRTEDAEVGKTLIVDLKYGPSRERSLAGVRRVSKPGLRVYAKSTNLPKVLGGLGVAIISTSTGLLTDRQAANQGVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NDKA_HUMAN
Sequence: MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.  Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities.  Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression.  Required for neural development including neural patterning and cell fate determination.  During GZMA-mediated cell death, works in concert with TREX1.  NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
What are the official names of this protein?
Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Granzyme A-activated DNase, GAAD, Metastasis inhibition factor nm23, NM23-H1, Tumor metastatic process-associated protein.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
Protein: ARAE1_ARATH
Sequence: MFSFGRARSQGRQNRSMSLGGLDYADPKKKNNYLGKILLTASLTALCIFMLKQSPTFNTPSVFSRHEPGVTHVLVTGGAGYIGSHAALRLLKESYRVTIVDNLSRGNLAAVRILQELFPEPGRLQFIYADLGDAKAVNKIFTENAFDAVMHFAAVAYVGESTQFPLKYYHNITSNTLVVLETMAAHGVKTLIYSSTCATYGEPDIMPITEETPQVPINPYGKAKKMAEDIILDFSKNSDMAVMILRYFNVIGSDPEGRLGEAPRPELREHGRISGACFDAARGIMPGLQIKGTDYKTADGTCVRDYIDVTDLVDAHVKALQKAKPRKVGIYNVGTGKGSSVKEFVEACKKATGVEIKIDYLPRRAGDYAEVYSDPSKIRKELNWTAKHTNLKESLETAWRWQKLHRNGYGLTTSSVSVY
What is the function of this protein?
Acts as a UDP-D-xylose 4-epimerase but lacks both UDP-D-glucose and UDP-D-glucuronic acid 4-epimerase activities in vitro.
What are the official names of this protein?
UDP-arabinose 4-epimerase 1, UDP-D-xylose 4-epimerase 1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: PQQB_PSEPW
Sequence: MYIQILGSAAGGGFPQWNCNCANCKGYRDGSLRATARTQSSIALSDDGVHWILCNASPDIRAQLQAFAPMQPARALRDTGINAIVLLDSQIDHTTGLLSLREGCPHQVWCTDMVHQDLTTGFPLFNMLSHWNGGLQWNLIELEGSFVIPACPNLRFTPFPLRSAAPPYSPHRFDPHPGDNLGLLVEDIRTGGKLFYAPGLGQVDDKLLAMMHGADCLLVDGTLWEDDEMQRRGVGTRTGREMGHLAQNGPGGMLEVLDGFPRQRKVLIHINNTNPILDEDSPERAEVQRRGVEVAFDGMSIEL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.
Protein: ARLY_LITCT
Sequence: MASEGDKLWGGRFVGSIDPIMEMFNSSVSYDQRMWSADIRGSQAYVKALEKAGLVSPTEMEHILTGLDQIHEEWSKGTFVLTKADEDIHTANERRLKELIGEPAGKLHTGRSRNDQVVTDMRLWLRDSCSALHLHLTRLIRTMVDRAAIEIDILFPGYTHMQRAQPIRWSHWILSHAVALCRDAERLGELRKRINVLPLGSGAIAGNPLGVDRELLRKELEFDSVSLNSMDATSERDFIAEFLFWASLCMTHLSKMSEDLIIYSTKEFSFVTLSDSYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCSGFLMTLKGLPSTYNKDLQEDKEAMFDVYDTVCAVLQVASGVISTLQINKEGMEKALSPDMLATDIAYYLVRKGMPFRQAHGLSGKVVQLAETKGIALNKLSLEDLKSISPLFSNDVSKVWNYTNSVEQYTAAGGTAKSCVVAQVEQLRTWLKKTQESVI
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Protein: GCH1_ACTPJ
Sequence: MSIISAEAQKVREALIAKGIETPTVQLTKDKDSRRAEIQQHMRSVLELLGLDLQDDSLEETPHRLAKMYVDEIFSGLDYATFPKITNIENRMKVSEMVLVDDITLTSTCEHHFVTIDGKVAVAYYPKKWVIGLSKINRVVQFFAQRPQVQERFTEQILTAFQTILETDDVAVFVKATHFCVKCRGVKDTNSYTVTSAFGGVFLEDRETRKEFLGLINK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: RL192_ARATH
Sequence: MVSLKIQKRLAASVMKCGKGKVWLDPNESGDISMANSRQNIRKLVKDGFIIRKPTKIHSRSRARALNEAKRKGRHSGYGKRKGTREARLPTKILWMRRMRVLRRFLSKYRESKKIDRHMYHDMYMKVKGNVFKNKRVLMESIHKMKAEKAREKTLADQFEAKRIKNKASRERKFARREERLAQGPGGGETTTPAGAPQQPEVTKKKSKK
What are the official names of this protein?
60S ribosomal protein L19-2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL19 family.
Protein: Y5968_METNO
Sequence: MAASPVLAVDNSSVAADQLKSIIERIERLEEEKAGLAGDIKDVYAEAKANGFDTKVLRKIISIRKRDHEERQEEEAILELYMQALGMA
What are the official names of this protein?
UPF0335 protein Mnod_5968.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: TIM50_CANAL
Sequence: MFRTQSRYLVRSILANHCVLPSTRMAVSPILNQSIKFYSSKDNATDKSQEKEQPKSILNDDMLARAGFEDVDPKEETSNSEEQATKQTGRKRKRAQTSKDLQRERYANMFYLSALIFGVAGVGYMSRDWDSEKEQEEMDGKNVENGYTPKLMYERLSKRLGSLFTFFSEPAFENLLPPPPPEQYRRPLTLVVTLDDFLIHSNWDTQHGWRTGKRPGLDYFLGYLSQYYEIVVFSSNSQIYSDKTVNKLDPYHAYISYALFREACRYKDGKLIKDLSLLNRDLGKTVMIDVDEDSAALQPENSIIVKKWEGQPDEYLISLIPFLEYLATQPVKDVRPILNSYKDKSNIVAEFAERENKLREQWRKDHGGNNGKPNAGNFIAKLLGIPVPEPKMPLDIIREHGQLQYEHFQKYLQENAHKFLEEEQKLKDEFGKVTLNKLITEGAPNAEEIAKVQQQRALEEAQKQQEGHK
What is the function of this protein?
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.  Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM50.
What is the protein family that this protein belongs to?
Belongs to the TIM50 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: CBID_METS3
Sequence: MTNENYTGVTTGTIATACSLAALESILDTSDIDCVKVKTPKKTLDIIIDECKRLSHSSACAVAHKNPYNDPDVTVGLAIVATVELLDKTSDGDSVIITGGEGVGKITKPGLQIPVGEYAINPVPRRMIRKNLERILPEDKVAKVTISIPEGRKIAKKTMNPKLGIVGGISVIGTTGIARSMSSEAYKNSIVTQIDVALALNLDNLVFVPGNIGEKLALKQLDITKQHIIQTGNYVGFMFEEAKKRGIDEFTFFGHIGKLIKIAGGIFNTKHAIADGRREIMITHAGICGADTKTLQKLYDSKTTEDMLDILDEENLHLDVCNSIALAIKERCMQRFDLDLNVILVDMEGNYLNDNFERFLL
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: GATA_GRABC
Sequence: MSALTDLTIAEARDGLRAKRFSARELTDAHLGAIEALNPRLNAYITVTPDQARAQAAAADRVLASGEAGALTGIPVASKDMFCSEGIRTTAGSRILENFVPPYESAVTERMLRDGAVILGKANLDEFAMGSANLTSAYGPVENPWKRHDDDAVLVPGGSSGGSAAAVAAHLALGATGTDTGGSIRQPASYCGIAGIKPTYGRCSRWGIVAYASSLDQAGPFARTVRDNAILLRSMAGHDPRDSTSAMREVPDFEAACQRGVKGLRIGLPREYVADGMSEEIRTLWQNGAAMLRAAGAEVVDVSLPHTKHALASYYIIAPAEASSNLARYDGVRFGHRSSDNRDLNDLYERSRAEGFGAEVKRRIMVGTYVLSAGYYDAYYLKAQKVRALIARDFAEAFRSVDALLTPTAPSAAFAQGETIDDPVAMYLNDVFTVPINLAGLPAMSIPAGLSTTGLPLGLQIIGRAFDEETVFAVSAALEQAAAFTHRPALRADTLNAGA
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: SDHB_CAEEL
Sequence: MLARSARLLHSAELAANAIRAASGAPATAAAAEASFPSTDDVAAKTKKTGNRIKTFEIYRFNPEAPGAKPTVQKFDVDLDQCGTMILDALIKIKNEVDPTLTFRRSCREGICGSCAMNIGGQNTLACICKIDSDTSKSTKIYPLPHMFVVKDLVPDMNLFYAQYASIQPWIQKKTPLTLGEKQMHQSVAERDRLDGLYECILCACCSTSCPSYWWNADKYLGPAVLMQAYRWVIDSRDDYATERLHRMHDSFSAFKCHTIMNCTKTCPKHLNPAKAIGEIKSLLTGFTSKPAAEPSAF
What is the function of this protein?
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Iron-sulfur subunit of complex II, Ip.
What is the protein family that this protein belongs to?
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: IHFB_ECO55
Sequence: MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: ADA_PLABA
Sequence: MEIPNEEIKFLKKEDIKNINLNGMNKKERYEIWKKIPKVELHCHLDLTFSGKFFLKWVRKYNLQPNMTDDQVLDHYLFTKEGKSLAEFIRKAISVSDIYRDYDILEDLAKWAVIEKYKEGVVLMEFRYSPTFVSSSHGLDIELIHKAFVKGIKNATEMLNNKIYVALICISDTGHSAASIKHSGDFAIKHKHDFVGFDHGGREIDLKDHKDVYHSVRNHGLHLTVHAGEDATLPNLNTLYTAINILNVERIGHGIRVSESEELIELVKKNNILLEVCPISNLLLNNVKSMDTHPIRKLFDAGVKVSVNSDDPGMFLTDINDNYEKLYIHLNFTLEEFMTMNNWALEKSFVNDDIKSKLKTMYF
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine to produce inosine (PubMed:19728741).  Unlike mammalian adenosine deaminases, also catalyzes the deamination of 5'-methylthioadenosine (MTA), a by-product of polyamine biosynthesis, to produce 5'-methylthioinosine (MTI) (PubMed:19728741).  Plays an essential role in the purine salvage pathway which allows the parasite to use host cell purines for the synthesis of nucleic acids (Probable).
What are the official names of this protein?
Adenosine deaminase, S-methyl-5'-thioadenosine deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Protein: RPA14_SCHPO
Sequence: MATECPPKMILRKSEKLDKDASSKFLNRYIQTIERFQDEKSGSESVLSQLNRVLMYLKGEEIPLISLNLPVQGPPTEELIIPPEEMLETKEEESLKHAREENDDLHLDKETKKRLKKEKKKAARREKEEARKAKADTTQGVGEKEQS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase I which synthesizes ribosomal RNA precursors.  A14 seems to play a role in the stability of Pol I subunit A43 and association of rrn3 to Pol I.
What are the official names of this protein?
DNA-directed RNA polymerase I subunit rpa14, RNA polymerase I subunit A14, DNA-directed RNA polymerase I 17 kDa polypeptide, Nucleolar protein ker1.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SELV_HUMAN
Sequence: MNNQARTPAPSSARTSTSVRASTPTRTPTPLRTPTPVRTRTPIRTLTPVLTPSPAGTSPLVLTPAPAQIPTLVPTPALARIPRLVPPPAPAWIPTPVPTPVPVRNPTPVPTPARTLTPPVRVPAPAPAQLLAGIRAALPVLDSYLAPALPLDPPPEPAPELPLLPEEDPEPAPSLKLIPSVSSEAGPAPGPLPTRTPLAANSPGPTLDFTFRADPSAIGLADPPIPSPVPSPILGTIPSAISLQNCTETFPSSSENFALDKRVLIRVTYCGLUSYSLRYILLKKSLEQQFPNHLLFEEDRAAQATGEFEVFVNGRLVHSKKRGDGFVNESRLQKIVSVIDEEIKKR
What is the function of this protein?
May be involved in a redox-related process.
What are the official names of this protein?
Selenoprotein V, SelV.
What is the protein family that this protein belongs to?
Belongs to the SelWTH family.
Protein: SKS1_YEAST
Sequence: MLSDCLLNNFRITAQIGSGAYGLVFHVVDILTSREYAVKTVFKSSSMDEFYNKNGLNNNSQVARTTLLQTQLYHFFKSFQKKLFLPSVDLDSILQLTENELNRLPHYREIAFQLRVQSHGNIVKIHQVLESSIATFIVMDYYDRDLFTSIVDDKHFVNHGILIKKVFLQLCSALDHCHRLGIYHCDIKPENVLLDRNDNAYLCDFGLSTKSKYLAPNVCVGSSYYMAPERILYCLNTTTNGIHVDECCSSLPTDTGDIWSLGIILINLTCIRNPWLKAHQKEDNTFQHFANDNNVLKKILPISDELFTVLTKILQLNPYTRIDMKTLMSEVSSLTSFTREGPLSQVPILSSEVYMTHIIRNENLFLSDLSHFSADQEQQQQQQQQQQQVQEQEQEQKQEQIQNQEQAQQQQEEEDAEPESDIPSTYNSDGSMEKYEYTNNHNNSTFLTSSMDSTPYQSDIDDVSASKDCKFQQDTLRNRLLCLQMNFSTLTDGPNEKWLPDY
What is the function of this protein?
May have a role in glucose regulation.
What are the official names of this protein?
Serine/threonine-protein kinase SKS1, Suppressor kinase of SNF3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: UNG_CAEEL
Sequence: MSKTVRIPDMFLKASAASKRKSASNTENIPEKVPAGNENQEVKKMKLQAPEPTEILLKSLLTGESWSKLLEEEFKKGYISKIEKFLNSEVNKGKQVFPPPTQIFTTFNLLPFDEISVVIIGQDPYHDDNQAHGLSFSVQKGVKPPPSLKNIYKELESDIEGFKRPDHGNLLGWTRQGVFMLNATLTVRAHEANSHAKIGWQTFTDTVIRIISRQSEKPIVFLLWGGFAHKKEELIDTKKHVVIKTAHPSPLSARKWWGCKCFSKCNTELENSGRNPINWADL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus.
Protein: THF1_SYNJA
Sequence: MNPVRTLSATKAAFFSAYPRPINAAYRRVVEELLVELHLTTVNSAFVYDPFFALGLVTLYDSLMEAYHPPEQREAIFNALCKALHLKPEVLRKNARDLLELMRSGDPVQRYNLLCLKPEAEDVGGLKAILQRMTQPPYAYSRVLAVGLYTAYEAVATSLYKEPEERTRHFLEDVIGNLPFSPERVKKDLELYRSNLDRLKQARAIVEEMVKAARRQQERRQSTASLPETPAADRRESSG
What is the function of this protein?
May be involved in photosynthetic membrane biogenesis.
What are the official names of this protein?
Protein Thf1.
What is the protein family that this protein belongs to?
Belongs to the THF1 family.
Protein: CLPS_ECO5E
Sequence: MGKTNDWLDFDQLAEEKVRDALKPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLAVHYQGKAICGVFTAEVAETKVAMVNKYARENEHPLLCTLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: NCAP_WCBV
Sequence: MDSEHIVFRVRNEIVTLKPEVISDQYEYKYPAITDKKKPSITLGRAPDLSIAYRSILSGFNAAKLDPDDVCSYLAAAMPLFEGVCPEDWISYGIIIARKGDKINPSHLVDIMRTEVEGNWSQSGGADVTRNPTVAEHASLVGLLLCLYRLSKIVGQNTANYKTNVADRMEQIFETAPFVKIIEHHTLMTTHKMCANWSTIPNFRFLVGTYDMFFSRIDHLYSALRVGTVVTAYEDCTGLVSFTAFLKQINLSARDAILYFFHKNFEEEIRRMFRPNQETAVPHSYFIHFRSLGLSGKSPYSSNAVGHVFNLIHFVGCYMGQVRSLNATVIQTCAPHEMSVLGGYLGEEFFGKGTFERRFFRDERELQDHLEAEEAKIDIALADDATVDSGDEDFYGGESRSPEAVYNRIIMNKGRLKKLHIKRYRSVSSNHQARPNTFAEFLNKVYSDDN
What is the function of this protein?
Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases.  If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA.  Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation.  The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace.  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.  Protein N binds protein P in the NC through a different interaction, and can be phosphorylated.  Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N.  During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
What are the official names of this protein?
Nucleoprotein, NP, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: DRC4_RAT
Sequence: MAPKRRGKKGKAKGNAVVDGVAPEDMSKEQVEEHVARIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLAEVKTEGTVVMKLAQKEHRAQEGALRKDMRVLKVELKEQELANEVVIKNLRLKQAEEITKMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEIHEVEERKNGQISTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEEYLEREMAEVSLQNKRLAEPLQRAKEEMSEMQKRLGNHERDKQILACTKARLKVTEKELKDLKWEHEILEQRFIKVQQEREELYRKFTAAIQEVQQKTGFKNLVLERKLQALNAAVEKREVQFNEVLAASNLDPTALTLVSRKLEDVLESKNTTIKDLQYELARVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGAPT
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.  Plays an important role in the assembly of the N-DRC linker.  Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement.  Required for proper motile cilia functioning.  Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner.
What are the official names of this protein?
Dynein regulatory complex subunit 4, Growth arrest-specific protein 11, GAS-11, Growth arrest-specific protein 8, GAS-8.
What is the protein family that this protein belongs to?
Belongs to the DRC4 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Associates with microtubules. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa.
Protein: AFFL_DROGR
Sequence: MAQQQQQQHLQQQQQQHHQQQQLQQLQQQQQLPQYNNNLYNLNYNMEDPERRKRREREKYERQQGIQSDDRETSLFEAPRRLNPSEGDNMITAALGEFVDAKEHMCMNMVGIHRQAPGGGSNARLQGQATTPIINSLSSINSTTTTSSSASLLPGQLPTSQQQQQQQQQQQQHYQQQQRAPTYLKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRSASSSSSASNNNSSSATNNATAAAATSASTAPLLGPPMSTQMPNGREKSYLGPPAPALSNGGRFVPPAASGKRTSNTAGLQPPPPEKDISKIINEMTNSYRVTPLTSIAATPHAPTRENYNLNGPNKNKYAFDDVEPIGPLNSPPAASGASSSSLSCTTNSSSSLLMTPLLAPIAPITSPIAPLLTTPPQASQLPLPLPLLPPLAGATTVLPPALGMAAVAPIQQLMPTPPKASPTPPTAIRPLKSEKNHSLEKQDSCLENDLELSESDDDRKRDICSAGNSSNSSETDSSESGSEASSKGEAQQQQQQQQQLLHHQHQQQLLLQQQQQQQQQQRATATTANGGNKKKCQTIIASGANTISGLLTSSGLGGSGGAVNATSNTNSGLLGGGGGSGSTGGGGGSSSSGMGNMSSSSSSNKTPSPTDSNRWHLSRFFPKPTNQATAESVSPGNVACGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKLHDDTRRITDDEDEDEQQQQRYAAGLSVTVKKEQQEQQQQQQQQQQQQQQQQQQQQQQQQLSAEQLALAGALPNNQIKREVRLSDSASISSGSASGSSSSDSAAGEVVPLPGPGETLQIPGVPAAITTVLRVPPAMQQKVPPNSVTLTPIGPLPASPKPRQKKPRKKKMSAATAPPLDSSDEDEPASSNKKHALELAATTAAAAAAIAAAPAATAAALPAVKKGRGRPRKQQQQLQQTQSGNLSSASAGSLAKGPTLTAAKKPLAKSTAAAAAAAALAATALTVAGSRKREHSSNSSSNGNTPTKKLHAAPATVAAAAAAAAAATTLLPPTAAAGSSSDEDSTSSSCSSTKSSNSSSSGSDSEATATTAAAATTAAAAAAATTTTTQNPAKKRIVKINKLGVVSSSKNNRLYGAGSSSNSSSSETEEQQQQQQQHKQQQQLLLMQQQQQQQQQQQQKQQLQQHQQQQPLQPQQQQQQQSHFTPDAKQARQRSSSSDGSSSSSTDSSSTNSSSSSDEVDVHHGGGKRKSDKKKICTLTRIFNPKEGGAKKQGQVVIIDQSEEQLQQQQQQLQQQQQQQQQHQQQQQQQQQQEQQQSKEWKPRATPTQLLGATLASPARTTTPHLTSLMCKIDLSKLARVPPEWYQKSYRQYAAEQQQQQQQHLHTQQLHHPPHHQHQHYQQQHQPHQQKAQQNGHLSSRSAEGARTPKELQQAYGMPNGYVTSGGAAGAAGAASKLLGGVKHEHGVKPEPELDAGYEAKYKPNSVKQEFMPKQEMPTRRRKRSSSSSPYKEKKRKKEKADQVSKELLPVPVLLPANNHERLSRDKLELLQQEISSANGSPTKRSFPLAHAQQQQHQQQQQQQQHQPQHQQQLKATTTTSTTATVAAVQTSTTATQQPTTCSEAVQTTPPPVAPPPPPRLIYRSHFDNEEEPPSDDLRKNEILLQEAIRRKRAADSERDSFKQMTLYLEAIVYFLLTADAMERSNMEATWTMYKDTLTLIKFISSKNRPYQQSTNGKHESHNIVAILSLRCQSLISLKLYKLRRANCRAIIASCSEFFRTGGRGDILNGNTLSSISPSNSVGSQGSGSNTPPGRIVPQDIHNQLCRQNEYLTYVNSAHDLWDQADRLVRTGNHIDFIRKLDHENGPMTLHSTMHEVFRYVQAGLKTLRDSVSYPQSQ
What is the function of this protein?
Has a role in transcriptional regulation.  Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth.  Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate.  Required specifically for the microtubule-based basal transport of lipid droplets.  Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye.  Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).
What are the official names of this protein?
AF4/FMR2 family member lilli, Protein lilliputian.
What is the protein family that this protein belongs to?
Belongs to the AF4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AP5B1_XENTR
Sequence: MAERNSASWNRKVASFCSEPKTFLCDSSVDGFLGELLKDLQSEAIHGQTKILMMDLLLEFPEFLCPDQKTVEMTAETLMNILKKMPSSERSMTLRCHLLLAIETVLITCESFNQNSKMAQDFASLLMHIISDVNDKKQGVANRPLRTTACECLRELESCYPGFLSQRMEKLYLMQQQEVTAAHQSYTLLYTVVLKNAIRFLAQKEGPSNGALKNALLSNEDFFWSATENMVELQPSSNEQLLLLPSNSETKDLKSILALLLEDSYLLTPVCQNTLFWQIVQVVAMARTISPVIFKSQLVRLFSTMDLSCFHSILQMKAVFTDSLFTGEDEHFLIQRLVGMTQHPLLSTPVKLFYLDCLLHFPENRPLTSNSEENLPVLLTVQMTSSLFPNVFNDHSTMLCRQNVLSMVYLENEGSYSEKGIAFLFEHVMSLYSMVHKNGNREITATFFRAVHLFVQYFNFCEKHMENLTEKLLKLYMSNSSLAPNFINLINQTQILLEFHVWPVTLSKALQKEIVNLPTDKWTMKNLGWHLKILSRVAQENSISQSSTALFLRRVVFCSDLCSKGDWRTGNALLSVCKHVLQHQKLSAIFVHLADLLQYLMHRFEDIDVQDRARLYYVLLTNVSSDKLGKILTMSPARGQTKSRSLSSIMTENENFSTMLTIRNAEKTLLCLQPVLEGIKAFTCISDSPSLYCIVLQFENTDCRFESISDINVPCLFVDRKPPVVTINLVPKEPYPTIFSVSATYSTQDGITYQTKLDPLYITFREMFIPLPLPALWPLESRFDLFGKLWSAFKPDEQNQFEESIFCYEMSNNSLHDIVLDNFSKFAVSCNGGEYKIAVFLPPQFHILMHIKSQDDTACFSVRTDNWNLLPYLNSHLLDITLQ
What is the function of this protein?
As part of AP-5, a probable fifth adaptor protein complex, it may be involved in endosomal transport.
What are the official names of this protein?
AP-5 complex subunit beta-1, Adaptor-related protein complex 5 beta subunit, Beta5.
Protein: ZNG1E_HUMAN
Sequence: MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVTSMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT
What is the function of this protein?
Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them.  Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation.  Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1.  After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis.  GTP/GDP exchange is required for release of active METAP1.
What are the official names of this protein?
Zinc-regulated GTPase metalloprotein activator 1E, Cobalamin synthase W domain-containing protein 5, COBW domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.