PharMolix/UniProtQA huggingface dataset:
Protein: FADJ_ECOL5
Sequence: MEMASAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDNFIAGADINMIGNCKTAQEAEVLARQGQQLMAEIHALPIPVIAAIHGACLGGGLELALACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQAVKLGLVDDVVPHSILLEAAVELAKQDRPSSRPLPVRERILAGPLGRALLFKMVGKKTEHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRNIFFASTEVKKDPGSDAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPQGINHALKYSWDQLEGKVRRRHLKASERDKQLALISGTTDYCGFAHRDLIIEAVFENLELKQQMVAEVEQNCATHTIFASNTSSLPIGDIAAHAARPEQVIGLHFFSPVEKMPLVEIIPHASTSAQTIATTVKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERIEHIDTALVKFGFPVGPIQLLDEVGIDTGTKIMPVLEAAYGERFSAPANVVSSILNDDRKGRKNGRGFYLYGQKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVCCLDEQVIRSVRDGDIGAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCNRFVEMSERGESFWKTTATDLQ
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S2540_DICDI
Sequence: MLSNSVNNNNNNNNINNSNSNNNDSNIHKNVKKLMVASIFGGIMSSLIVTPLDVVKTRLQTQNTGSHINQKHVFKGTLDAFKKIYKNEGPLTFWRGVTPSLLMTIPSATIYFTSYEYLKEYLYQFNDTEAYNIYTVPLVAGTLARIFSASVTSPFELLRTNSQGIVLQNAYKNTVAMAASSSTATIGTIPLSSEQRFNSFKLYRDIVNNVGIKGLWRGLGPTLVRDVPFSAIYWAGYEVLKNKLMKSQIDPNFSRNSKSPFFINFIAGATSGTLAAVLTTPIDVIKTRIQMSAQQTLSPSLTPQQQLDFIKKNNSSIYHLKQILSQEGWKGLTKGLVPRVAKVSPACAIMISTFEYIKQSHIADDN
What is the function of this protein?
Mitochondrial transporter required for glutathione import into mitochondria.
What are the official names of this protein?
Mitochondrial substrate carrier family protein H, Solute carrier family 25 member 40 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DJLA_PECAS
Sequence: MRYWGKLLGLALGIVSSTGIWGMIMGLLMGHWIDRARASRRRDYFSAQSTRQSLFFLTTFQAMGHLTKSKGRVTEADINIATKMMDRLELFGDARAAAQRAFREGKAGQFPLRIKLRKLRDACLGRFDLIKMFLEIQLQVAFVDGVLHPNERRVLYVIADELGVTREQFEFFLRNMESPTGQQSRQNQSRQNGKSQQRRNNGYSNGHSYGGQRPPSPLRGPTVESACRTLGVRSSDDAVTIKRAYRKLMSEHHPDKLVAKKLSPRMMEMAKRKAQDIQAAYELLKSANQTK
What is the function of this protein?
Regulatory DnaK co-chaperone.  Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway.  The colanic acid capsule may help the bacterium survive conditions outside the host.
What are the official names of this protein?
Co-chaperone protein DjlA.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type III membrane protein.
Protein: U519A_DICDI
Sequence: MTIINSISSLGKISNKNKSQNNLNGINNSNSSSNIQGSNQNTGIVSGLLEIVRGVVLALGVVVGAIGL
What are the official names of this protein?
UPF0519 protein A.
What is the protein family that this protein belongs to?
Belongs to the UPF0519 family.
Protein: MFNF_METVA
Sequence: AEFVSQNIDKNCILVDMGSTTTDIIPIVDGKAASNKTDLERLMNNELLYVGSLRTPLSFLSNKIMFKDTITNVSSEYFAITGDISLVLDKITEMDYSCDTPDGKPADKRNSLIRISKVLCSDLNQISADESINIAIEYYKILIDLILENVKKVSEKYGLKNIVITGLGEEILKDALSELTKSNEFNIISIKERYGKDVSLATPSFSVSILLKNELNAKLNRS
What is the function of this protein?
Catalyzes the condensation between 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) and gamma-glutamyltyramine to produce APMF-Glu.
What are the official names of this protein?
(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase, 4-[[4-(2-aminoethyl)phenoxy]-methyl]-2-furanmethanamine-glutamate synthase, APMF-Glu synthase.
What is the protein family that this protein belongs to?
Belongs to the MfnF family.
Protein: HUTI_HAHCH
Sequence: MDWWINARIATLDPDAQHAYGLLESHALGVAHGKVEAIVPMSEWDGDASDNITDANGRLITPGLVDCHTHLVYGGDRAAEFEMRLQGVSYADIAKQGGGIISTVRATRAATEKELLQQSEKRLLALLREGVTTVEIKSGYGLDLESELKMLHVARRLGQRYPVNVRTTLLAAHALPPEYAGRSDDYISWICEEALPVAHEQKLADAVDVFCESIAFTPEQCRRVFEAAQKLGLPVKGHMEQLTLSGGSALAAEFNALSVDHVEYLDEASVQAIAASGTVATLLPGAFYFLRETQRPPMELLRKHKVPMALATDLNPGSCPLASMRLMMNMGCTFFGMTPEETLAGVTRHGAKALGMQDRIGHLAPGMAADFIVWDCQHPAQLSYEFGVTGPHQRVFHGEIHNV
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_NITWN
Sequence: MVVILDTISANPVRPRHPEKANRPDALSPPKPDWIRVRAPNTRGYANTRRIVKENGLVTVCEEAGCPNIGECWDKKHATFMIMGDTCTRACAFCNVKTGMPGAIESSEPEYVAEATRKLGLAHVVVTSVDRDDLDDGGAEHFAQTIRAIRERCPATTIEILTPDFLRKDGALEKVVAAKPDVFNHNLETVPSRYLTVRPGARYFHSIRLLQRVKEIDPAIFTKSGIMVGLGEERHEVLQVMDDLRSADVDFLTIGQYLQPTRKHHAVIRYVTPEEFSSYETVAYTKGFLMVSASPLTRSSHHAGEDFAKLQAARATLSR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAG_THIDA
Sequence: MAEGKKYQINISVNTAYLAEQSDPSADRYVFAYTITIENVGTVAAQLISRHWVITDADDVVQEVKGLGVVGEQPLLRPGETFEYSSGAALATPVGTMQGSYQMVAEDGNKFDAEIPRFTLAMPRVLH
What are the official names of this protein?
Protein ApaG.
Protein: FABZ_STAHJ
Sequence: METIFDYNQIKQIIPHRQPFLLIDRVVEYEEGKRCVGLKQVSGNEPFFQGHFPDYAVMPGVLITEALAQTGAVAMLNSEENKGKIALFAGIDKCRFKKQVTPGDTLMLEVEITKIKGPIGKGTAKATVDGQLACSCELTFAIQNA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPB_PSEPU
Sequence: MTQSQYRPGPDANGLFGSFGGRYVAETLMPLVLDLAREYEAAKADPKFLEELAYFQRDYIGRPNPLYFAERLTEHCGGAKIFFKREELNHTGAHKVNNCIGQVLLAKRMGKKRLIAETGAGMHGVATATVAARFGLPCVIYMGATDIERQQANVFRMKLLGAEIVPVTAGTGTLKDAMNEALRDWVTNVEDTFYLIGTVAGPHPYPAMVRDFQSIIGKETRAQLQEKEGRLPDSLVACVGGGSNAMGLFHEFLEEPSVQIIGVEAGGHGVHTDKHAASLNGGVPGVLHGNRTYLLQDEDGQITDAHSISAGLDYPGIGPEHAYLHEVKRVEYVSITDDEALDAFHATCRLEGIIPALESSHALAEAIKRAPKLPKDHLMVVCLSGRGDKDMQTVMNHMAAQEKQA
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RHG12_MACFA
Sequence: MKMADRSGKIIPGQAYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSKAFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPSSSVQGTGLTRDANQNFGPSYNPGHTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRLFGHFPGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYDRGTQERTWKPPRWTRDASISKGDFQSPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYTNEKWLKHIDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTASSPKDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVDTDEGIEEEILPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEYGLDVDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLKRVVENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFGR
What is the function of this protein?
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
What are the official names of this protein?
Rho GTPase-activating protein 12, Rho-type GTPase-activating protein 12.
Protein: GLNA2_ARATH
Sequence: MAQILAASPTCQMRVPKHSSVIASSSKLWSSVVLKQKKQSNNKVRGFRVLALQSDNSTVNRVETLLNLDTKPYSDRIIAEYIWIGGSGIDLRSKSRTIEKPVEDPSELPKWNYDGSSTGQAPGEDSEVILYPQAIFRDPFRGGNNILVICDTWTPAGEPIPTNKRAKAAEIFSNKKVSGEVPWFGIEQEYTLLQQNVKWPLGWPVGAFPGPQGPYYCGVGADKIWGRDISDAHYKACLYAGINISGTNGEVMPGQWEFQVGPSVGIDAGDHVWCARYLLERITEQAGVVLTLDPKPIEGDWNGAGCHTNYSTKSMREEGGFEVIKKAILNLSLRHKEHISAYGEGNERRLTGKHETASIDQFSWGVANRGCSIRVGRDTEAKGKGYLEDRRPASNMDPYIVTSLLAETTLLWEPTLEAEALAAQKLSLNV
What is the function of this protein?
The light-modulated chloroplast/mitochondrial enzyme, encoded by a nuclear gene and expressed primarily in leaves, is responsible for the reassimilation of the ammonia generated by photorespiration.
What are the official names of this protein?
Glutamine synthetase, chloroplastic/mitochondrial, GS2, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion.
Protein: ZDHC7_HUMAN
Sequence: MQPSGHRLRDVEHHPLLAENDNYDSSSSSSSEADVADRVWFIRDGCGMICAVMTWLLVAYADFVVTFVMLLPSKDFWYSVVNGVIFNCLAVLALSSHLRTMLTDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILLIFLCLEGLLFFTFTAVMFGTQIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFGGPPSLLWMNPFVGFRFRRLPTRPRKGGPEFSV
What is the function of this protein?
Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865).  Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).  Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296).  Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095).  Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068).  In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321).  Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865).  Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity).  In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity).  Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity).  Could also palmitoylate NCDN (By similarity).  May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).
What are the official names of this protein?
Palmitoyltransferase ZDHHC7, Acyltransferase ZDHHC7, Zinc finger DHHC domain-containing protein 7, DHHC-7.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: RS4_TREPS
Sequence: MAVKRARGKIVRRLGINIFGNPKYTRLLGKKPAPPGKEHGVKQRAKVSVYGEQLKEKQKFRFAYGMSERQFRNLFAQAHRMKGVTGNNMLSLMERRLDNTVFRMGFAISRVQARQMVSHRYFLINGKTANIPSMRISAHDVITTKNRKGIHSIIRHNLTLSQGQRGSWLNVDEEQLSATVSELPRAQDIHPVGNIQHIVEYYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RS14Z_SOLM1
Sequence: MARKSLMVKASRKPKFSTRAYNRCPICGRPRAYLRKFGVCRICFRNMSLTGEMPGVRKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: RNZ_MYCBP
Sequence: MLEITLLGTGSPIPDPDRAGPSTLVRAGAQAFLVDCGRGVLQRAAAVGVGAAGLSAVLLTHLHSDHIAELGDVLITSWVTNFAADPAPLPIIGPPGTAEVVEATLKAFGHDIGYRIAHHADLTTPPPIEVHEYTAGPAWDRDGVTIRVAPTDHRPVTPTIGFRIESDGASVVLAGDTVPCDSLDQLAAGADALVHTVIRKDIVTQIPQQRVKDICDYHSSVREAAATANRAGVGTLVMTHYVPAIGPGQEEQWRALAATEFSGRIEVGNDLHRVEVHPRR
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: Y1413_METJA
Sequence: MGGMITTTTPYIEGKKIIKYLGFVHGVASVYVTVKYYEDVKDAYERALRESEDTALIRMVDNAKKLGANAIIGINSNYAMVGEKGDMIMVGIYGTAVVVEEDG
What are the official names of this protein?
UPF0145 protein MJ1413.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: GPPA_ERWT9
Sequence: MRSASSLYAAIDLGSNSFHMLVVREVAGSIQTIARIKRKVRLAAGLDADNNLSAEAMDRGWQCLRLFSEQLQDIPPEQIRVVATATLRIAANAGSFLAQAQKLLGCPVNVISGEEEARLIYQGVSHTTGGSDKRLVVDIGGGSTELVTGRGSQPTTLYSLSMGCVTWLERYFSDRQLGKVNFEQAEQAARAMIRPIADSLKAQGWQVCVGASGTVQALQEIMMAQGMDERITLNKLQQLKQRAIECGKLEELEIEGLTLERALVFPSGLSILIAIFSELNISSMTLAGGALREGLLYGMLPLPVDRDIRSRTLHDVQRRFSVDPEQAERVRQLADSFARQVSLQWKLDDRSRELLGSACLLHEIGLSVDFRQAPQHAAYLVRYLDLPGFTPAQKKLLATLLQNQVGNIDLPLLSQQNALLPRIAERLSRLLRLAIIFASRRRDDRLPAVRLQADDDNLTVTLPSGWLEAHPLRAELLEQEARWQGYVHWPLIIA
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: FCY22_YEAST
Sequence: MPEKLAMSMVDIKDAGSELRDLESGALDTKSSAADVYYEGVELHRTNEFIDNKPSFFNRIAAALNAETKGIEPVTEDEKNDDSILNAATIWFSANMVIVAYSVGALGPLVFGLNFGQSVLVIIFFNILGLIPVALFSLFGVELGLRQMILSRYLAGNITARFFSLVNVIACVGWCVLNISVSAQLLNMVNEGSGHNCPIWAGCLIIAGGTVLVTFFGYSVVHAYEKWSWVPNFAAFLVIIAQLSRSGKFKGGEWVGGATTAGGVLSFGSSVFGSAAGWATYAADYTVYMPKTTSKYKIFFSVVAGLAFPLFFTMILGAACGMAALNDPTWKSYYDKNAMGGVIYAILVPNSLNGFGQFCCVLLALSTVANNVPGMYTVALSAQALWAPLAKIPRVVWTMAGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAIACSEHFIYRRSFSAYNIDDWDNWEHLPIGIAGTAALIAGAFGVALGMCQTYWVGEISRLIGEYGGDIGFELGGSWAFIIYNIVRPLELKYFGR
What is the function of this protein?
Probable purine-cytosine permease.
What are the official names of this protein?
Purine-cytosine permease FCY22, PCP FCY22, Cytosine/purine transport protein FCY22, Fluorocytosine resistance protein 22.
What is the protein family that this protein belongs to?
Belongs to the purine-cytosine permease (2.A.39) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MUTS_BORHD
Sequence: MKKDVTPMMRQYLSIKNKHKDAILFFRVGSFYEMFFDDALEGSKLLGLTLTKREDIPMCGVPCHTSKEYIKKLILLDRKVAICEQGGVQTDPKGPLEREVVEVISPGVVVDEDFLQDDVNNYLVAISDYKDYYSFSYIDLSTSRLGIILYEGSFLEKLRRDIEKYSPKEIIVSESFYYKYLEKLALDRFLVNKVPHWHLDKDIAIKSLKDHFNVLSLSAFGFKEDEPYYISSFLIIDYIKNNLKNLLINIDTIYINSDSEYMFLDDVTQINLELVKNNNDLTARYSLYSVLNDCKTPMGKRLLREYILNPLLDIAAINNRLDHVEFLNNNVNLSIKLREILSNVWDIERIISRLQMRKYAKKDFLFIRETLIAFFSVKRLLNEYSFNYWIFDVNDEGDIRGIYSLIDCAISNEQDELIKQGYNSEIDRLRELKNNASKYVDDYLDFERNFSKINSLKIKRINVRGLFFEVTKSYYGQVPSHFIESQTLNSVKRYKTNKLIELERDINDAEDNLLSLEQEIFDEIALKVVKYSTVIKKVAEFCAYIDVVSNFAYLAKKNEYVRPTLTNNKEIILECARHPVVEHYMKGVEAFTRNSVRIDGEKYFCLITGPNMAGKSTYLRQTALVVLMGHIGSFVPANKAIIGITDKIFCRIGASDNISKGESTFLVEMNETANILRNATQDSLIIMDEVGRGTSTNDGLAIACSIVEYILEDIKARSLFATHFHELSAINHDSFVNLSMKIERQGNELIFLREVEEKPSLNSYGIYVARIAGIPLKVIKRANIILKSLTSRENLCVSEFFTSATSVVNDGEDTMEEDLSYELDLNAYLELKNLISKIDINNITPFQAMNLLSEIILKTKM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RF2_ECOLC
Sequence: MFEINPVNNRIQDLTERSDVLRGYLDYDAKKERLEEVNAELEQPDVWNEPERAQALGKERSSLEAVVDTLDQMKQGLEDVSGLLELAVEADDEETFNEAVAELDALEEKLAQLEFRRMFSGEYDSADCYLDIQAGSGGTEAQDWASMLERMYLRWAESRGFKTEIIEESEGEVAGIKSVTIKISGDYAYGWLRTETGVHRLVRKSPFDSGGRRHTSFSSAFVYPEVDDDIDIEINPADLRIDVYRASGAGGQHVNRTESAVRITHIPTGIVTQCQNDRSQHKNKDQAMKQMKAKLYELEMQKKNAEKQAMEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVETRNTQAVLDGSLDQFIEASLKAGL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EST1A_HUMAN
Sequence: MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG
What is the function of this protein?
Plays a role in nonsense-mediated mRNA decay (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788).  Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788).  Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788).
What are the official names of this protein?
Telomerase-binding protein EST1A, Ever shorter telomeres 1A, hEST1A, Nonsense mediated mRNA decay factor SMG6, Smg-6 homolog, hSmg5/7a.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome, telomere. Cytoplasm, cytosol. Note=Particularly enriched in the nucleolus.
Protein: NADE_STRZJ
Sequence: MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFVLGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLPYGVQADEADAQKALAFIQPDVSLVVNIKESADAMTAAVEATGSPVSDFNKGNIKARCRMIAQYALAGSHSGAVIGTDHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQKLGAEPALYEKIPTADLEEDKPGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRHLPITVFDDFWE
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: RL13_NEIG1
Sequence: MKTFSAKPHEVKREWFVIDAQDKVLGRVATEVASRLRGKHKPEYTPHVDTGDYIIVINADKLRVTGAKFEDKKYFRHSGFPGGIYERTFREMQDQFPGRALEQAVKGMLPKGPLGYAMIKKLKVYAGAEHAHAAQQPKVLELK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: US04_HCMVA
Sequence: ATTCQKRRYGTFRTGISKPGLSTRRFQHRDFSHGDFGTGTFRTAVSPPLTFSSPPTSTVATPYFPMRFINVKSHVSRPPPLHGDIPIGHEGTRVSRHVDDRCGLVVVSRHGRAGGCLSR
What are the official names of this protein?
Uncharacterized protein US4.
Protein: RS10_PELPB
Sequence: MAVQQKIRIKLKSYDHSLVDKWALRIIDVVKQTDAIIFGPIPLPTKSHVYTVNRSPHVDKKSREQFSFSSHKRLIEIINPTSRTIDMLMKLELPSGVDVEIKS
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: SBCD_STAS1
Sequence: MKIIHTADWHLGRILNGKSLLEDQAYILDKFIEAMKLEQPDVIVIAGDLYDTSYPNKDAIQLLEQTIDILNLEMSIPLIMINGNHDSKERLNYGSKWFEKSHMYIRTDLNDMNKPVTIGNVDFYTMPFATINEMQYFFDDKAIETHQQALNRVLAYMHEVIDENKVNIFVGHLTVQGGIRSESERPLTIGTVESVDENLFNQFDRVMLGHLHHPFSIESNFINYSGSLLQYSFSETKQPKGYKIVEIKNQKITDKFIPLKPLRQLEVIEGNYEDAIQEKLEVKHKENYLHFKLKHMSHVSDPMMHLKQIYPNTLALTNQTFDFNTSIHHENIEIQKLDDETIIDNFYNSITGEHLTTNQSKKIEKIMTALLEEGSK
What is the function of this protein?
SbcCD cleaves DNA hairpin structures.  These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions.  The complex acts as a 3'->5' double strand exonuclease that can open hairpins.  It also has a 5' single-strand endonuclease activity (By similarity).
What are the official names of this protein?
Nuclease SbcCD subunit D.
What is the protein family that this protein belongs to?
Belongs to the SbcD family.