PharMolix/UniProtQA huggingface dataset:
Protein: EGLB_ASPNC
Sequence: MKFQSTLLLAAAAGSALAVPHGSGHKKRASVFEWFGSNESGAEFGTNIPGVWGTDYIFPDPSTISTLIGKGMNFFRVQFMMERLLPDSMTGSYDEEYLANLTTVVKAVTDGGAHALIDPHNYGRYNGEIISSTSDFQTFWQNLAGQYKDNDLVMFDTNNEYYDMDQDLVLNLNQAAINGIRAAGASQYIFVEGNSWTGAWTWVDVNDNMKNLTDPEDKIVYEMHQYLDSDGSGTSETCVSGTIGKERITDATQWLKDNKKVGFIGEYAGGSNDVCRSAVSGMLEYMANNTDVWKGASWWAAGPWWGDYIFSLEPPDGTAYTGMLDILETYL
What is the function of this protein?
Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan.  Involved in the degradation of complex natural cellulosic substrates (By similarity).
What are the official names of this protein?
Probable endo-beta-1,4-glucanase B, Endoglucanase B, Carboxymethylcellulase B, Cellulase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GATB_NOSP7
Sequence: MTTATTVKTEYEAIIGLETHCQLSTKTKIFSNSSTAFGADPNTNIDPVCMGLPGVLPVLNEKVLEYAVKTGLALNCQIARYSKFDRKQYFYPDLPKNYQISQYDLPIAEHGWLEIELVDAEGNPSRKRIGITRLHMEEDAGKLVHAGSDRLSGSSYSLVDYNRAGIPLVEIVSEPDLRSGLEAAEYAEELRRIVRYLGVSDGNMQEGSLRCDVNISVRPVGRKEFGTKVEIKNMNSFSAIQRAIDYEIERQIAAIEAGDRIIQETRLWEEGAQRTSSMRVKEGSSDYRYFPEPDLAPIEVSNEQLENWRSELPELPAQKRHHYESELGLSAYDARVLTEDRSIAEYFETAIASGANPKAAANWITQDIAAHLNKQKLTITQIELTPTNLAEIITRIETGKISNAQAKEKLPDLLSGISPEKAFAGLELITDPTVLEPIVDEVIAANPKELEKYRNGNTNLKGFFVGQVLKKTAKRADPKLTNELVEKKLNA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: PRSA_STAA8
Sequence: MKMINKLIVPVTASALLLGACGASATDSKENTLISSKAGDVTVADTMKKIGKDQIANASFTEMLNKILADKYKNKVNDKKIDEQIEKMQKQYGGKDKFEKALQQQGLTADKYKENLRTAAYHKELLSDKIKISDSEIKEDSKKASHILIKVKSKKSDKEGLDDKEAKQKAEEIQKEVSKDPSKFGEIAKKESMDTGSAKKDGELGYVLKGQTDKDFEKALFKLKDGEVSEVVKSSFGYHIIKADKPTDFNSEKQSLKEKLVDQKVQKNPKLLTDAYKDLLKEYDVDFKDRDIKSVVEDKILNPEKLKQGGAQGGQSGMSQ
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: MOXD2_HUMAN
Sequence: MAHDLLFRLFPLLALGVPLQSNRLGPTSRLRYSRFLDPSNVIFLRWDFDLEAEIISFELQVRTAGWVGFGVTNRYTNVGSDLVVGGVLPNGNVYFSDQHLVEEDTLKEDGSQDAELLGLTEDAVYTTMHFSRPFRSCDPHDLDITSNTVRVLAAYGLDDTLKLYRERTFVKSIFLLQVVHPDDLDVPEDTIIHDLEITNFLIPEDDTTYACTFLPLPIVSEKHHIYKFEPKLVYHNETTVHHILVYACGNASVLPTGISDCYGADPAFSLCSQVIVGSAVGGTSYQFPDDVGVSIGTPLDPQWILEIHYSNFNNLPGVYDSSGIRVYYTSQLCKYDTDVLQLGFFTFPIHFIPPGAESFMSYGLCRTEKFEEMNGAPMPDIQVYGYLLHTHLAGRALQAVQYRNGTQLRKICKDDSYDFNLQETRDLPSRVEIKPGDELLVECHYQTLDRDSMTFGGPSTINEMCLIFLFYYPQNNISSCMGYPDIIYVAHELGEEASE
What are the official names of this protein?
Putative DBH-like monooxygenase protein 2, DBH-like monooxygenase protein 2 pseudogene.
What is the protein family that this protein belongs to?
Belongs to the copper type II ascorbate-dependent monooxygenase family.
Protein: ADAM5_MACFA
Sequence: MFLLLVLLTGLGGMHADLNPHKTFLQTTIPEKISSSDAKTDPEHNVVYMITIEGKPYFVHLKKQSILSSASFIHSYDKNDIRHSKPLLVQMDCNYNGYVAGIPNSLVTLSVCSGLRGTMQLKNISYGIEPMEAVSGFIHKIYEEKFADTNILLEENDTYSWFNSEYQVRKSSEKTDFIKLFPRYIEMHIVVDKNLFDYMGSDINAVTQKVIQIIGLVNTMLTQLQLTVIISSIEIWSNKNKISTTGHAEYVLLEFFEWKKDHLNFKPHQIAYLFVYRKLPTLIGATFPGQVCNKDFAAAVALYPEGLSLESYTVIIVQLLGLNLGLTYDKTDTCHCSGDVCTMTPKAVYSGGVKDFSVCSLDDFKYISSHNGLTCLQTNPLEMPTYTQRRICGNGLLEGGEECDCGNKDNCTHKLCCDALTCRLKDNAQCGSGDCCSKDCKFKPANTICRKSVDVECDFTEFCNGSYPYCLLDTYVRDGEYCDSGGAFCFQGRCRTFDKQCDDLIGRGSRGAPIFCYDEINTRGDKFGNCGTEYCLFQHILCGKLVCTWEHKDLISRPNLSVIYAHVRDQTCVSTYLPSRKPPPVASTVSKTSYYSVDDRDETFVQDGSVCGPDMYCFKMRCKHVRFLMDFETCEASIECSGHGICNNFNHCHCEKGYNPPHCKPKKEAFGSTDDGHLVPAEKSYMEEGRHAPFQKQRFQLIFYISLPVLIITTAILIKRKKLRELCYRGETESESSVSQESSSNSKSSLSESTSL
What is the function of this protein?
This is a non catalytic metalloprotease-like protein.  May play a role in sperm-egg fusion (By similarity).
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 5, Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II, tMDC II.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MIAB_STRV1
Sequence: MSSIDRSQSVGGTRTYEVRTYGCQMNVHDSERLAGLLEDAGYVRAPEGSDGDADVVVFNTCAVRENADNKLYGNLGHLAPKKARRPGMQIAVGGCLAQKDRDTIVKRAPWVDVVFGTHNIGKLPVLLERARVQEEAQVEIAESLEAFPSTLPTRRESAYAAWVSISVGCNNTCTFCIVPALRGKEKDRRPGDILAEIEALVAEGVSEITLLGQNVNAYGSDIGDREAFSKLLRACGRIDGLERVRFTSPHPRDFTDDVIAAMAETPNVMPQLHMPLQSGSDAVLKAMRRSYRQERYLGIIEKVRAAIPHAAISTDIIVGFPGETEEDFEQTLHVVREARFAQAFTFQYSKRPGTPAAEMDGQIPKKVVQERYERLVALQEEISWEENKKQVGRTLELMVAEGEGRKDDTTHRLSGRAPDNRLVHFTKPEQEVRPGDVVTVEITYAAPHHLLAEGPVRDVRRTRAGDAWEKRNAAEAAKPAGVMLGLPKVGVPEPLPAVTGGCAVD
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR1D2_PANTR
Sequence: MDGGNQSEGSEFLLLGMSESPEQQRILFWMFLSMYLVTVVGNVLIILAISSDSCLHTPMYFFLANLSFTDLFFVTNTIPKMLVNLQSQNKAISYAGCLTQLYFLVSLVALDNLILAVMAYDRYVAICCPLHYTTAMSPKLCILLLSLCWVLSVLYGLIHTLLMTRVTFCGSRKIHYIFCEMYVLLRMACSNIQTNHTVLIATGCFIFLIPFGFVIISYVLIIRAILRIPSLSKKYKAFSTCASHLGAVSLFYGTLCMVYLKPLHTYSVKDSVATVMYAVVTPMMNPFIYSLRNKDMHGALGRLLDKHFKRLT
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1D2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NANM_ECO24
Sequence: MNKTITALAIIMASFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATSAFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTNSWVKLMSHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNEAGKDSTAVDKINAYYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFELDFTGNNLKWNKLAPVSSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQNGKNYAHEGLKKSYSTDIHLWHNGKWDKSGELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVFISVKDNKVTVQN
What is the function of this protein?
Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers.  Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer.  In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
What are the official names of this protein?
N-acetylneuraminate epimerase, N-acetylneuraminate mutarotase, Neu5Ac mutarotase, Sialic acid epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanM family.
What are the subcellular locations of this protein?
Periplasm.
Protein: NTPP_CYAP4
Sequence: MLQFVLASASPARRQLLQSIGINPLVYQSNFDESSVAIADHHELVQTLARCKAEVVANQLAAPALVLGCDSVLVLQGKIYGKPKDPADAIARWQSMRGQSGELLTGHTLIDLYQNKTLVRLEITQVDFAWISDRQIAAYVATGEPLNCAGAFALDGRGGLFVDRIVGCPSNVIGLSLPLLRKMLTALGYSPADCW
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSTT_ENTFA
Sequence: MVKAIRKLSLIQKIMIGIVIGTTLGFLVPEWTFISVLGELFVGALKAIAPILVFVLIIASLAQQKAGAKTYVGSILVVYLLATFLAAVVAVTASYLFPVKIVLEAAQEAQAAPTQLSDVLSNVLTSVVQNPIQAMIEGNYLSVLFWSSLIGIGLRQSSVATKDVIANLSTGITTVVQMIIGIAPIGILGLVFHSVATTGIAGLAKYGQLLLLLIGTMAVVALVVYPAIVFWNIRQNPYPLVFFVLKESAIPAFFTRSSAANIPINMELAKAMDLNEESYAVSIPLGATINMGGAAITITIMTLAAVHTLGMSVPIYLALLLSIIAAVSACGASGIAGGSLLLIPLACSLFGISNDIAMQVVGVGFIVGVVQDSIETALNSSSDLLFTTSVELADRRKNGEIIDVKALIGKSQLVVEQENI
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: L83L_ASFP4
Sequence: MDTSLKNNDGALDADNKNYQDYKDEPDKTSDVLDVTKYNSMVDCCHKNYSTFTSEWYINERKYNDVPEGPKKADVHRCTII
What is the function of this protein?
May subvert the host innate immune response by interacting with host IL1B and interfering with its function.
What are the official names of this protein?
Protein L83L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus L83L family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: ATP5J_MOUSE
Sequence: MVLQRIFRLSSVLRSAVSVHLKRNIGVTAVAFNKELDPVQKLFVDKIREYKSKRQASGGPVDIGPEYQQDLDRELYKLKQMYGKGEMDTFPTFKFDDPKFEVIDKPQS
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.  Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
What are the official names of this protein?
ATP synthase-coupling factor 6, mitochondrial, ATPase subunit F6, ATP synthase peripheral stalk subunit F6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ATPase subunit F6 family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: DAPF_RHIEC
Sequence: MSATVEFARMNGLGNKILVVDMRGRSDKVTPAAAVALNADPQTEFDQIMAIHDPKADGTDAFIDILNSDGSKAQACGNGTRCVVQALAAETGRKAFTFQTVAGILNAIEHEDGTISVDMGKPVFDWDRIPLAEEFHDTSRIELQIGPIDNPLLHSPSAMSMGNPHAIFWVDKDVMSYDLARFGPLLENHPMFPERANITLAQVTSPTTMTTRTWERGAGLTLACGSAACSAAVSAARTGRTGRKVKINVASAKPPAMLSIEWRERDDHVIMTGPAEWEWSGRLDPATGCWSRDDAREVEAQ
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VRTI_PENAE
Sequence: MGARSKEARHRWFSRLPPDASSSFLPCKRPKSVAFVLWIRPSCFLRESLPAELSGLPGLPLPPQAPTNTMNCGLPEAALSVIDWGRLKSGDVNEGARLLSACDDQGFFYLDLSSEPSFLHDHKSVLHFMDQYFHQGLADKMKDDRQSDTHGYEPVATSTGALNTLPDYYESLKASRDELHGDGRNLAPAVCDRQDLFLRFSDMMHQMVIAILQELDCQLGFGGDRASFQDFHRKDAESLTTLSMFRYPKQETLDLGVGHNKHTDIGTLTFLLCDQWGLQVLSKDPAGWRFVAPREGHAVINVGDTLRFLSGNRFRSAVHRVIPTQRLQHEDRYSIAYFLRAANDTQFTDSAGRQVSAKQWHDEKFDVFRETHEEQEKMPILTGGMERLENLPGIWCGVRLTDGICHRLGAEDC
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system (PubMed:20534346).  The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA (PubMed:20534346).  The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB (PubMed:20534346).  The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone (PubMed:20534346).  The cyclization of the last ring could be mediated by the lactamase-like protein vrtG (PubMed:20534346).  The proposed post-PKS tailoring steps are an hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF (PubMed:20534346, PubMed:24161266).  VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin (PubMed:20534346).  Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin (PubMed:24161266).
What are the official names of this protein?
Oxidoreductase vrtI, Viridicatumtoxin synthesis protein I.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: RUVA_SHEFN
Sequence: MIGRLSGILVEKQAPEVVLDVNGVGYELQVPMTSFYELPALNQAAMLFTHFVVREDAQLLYGFITKQERALFRLLIKTNGVGPKLALTILSGMTASEFVSCVERDDIATLVKLPGVGKKTAERLVIEMRDKLKSLLEASAGSEREFMLQSNYTPAAAVDSAEEDAISALLSLGYKPAQASKSVSAAFKEGMSSETLIKAALKSML
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: CUE5_SCHPO
Sequence: MASEQSNPRLPRRPPYMAEKARATLKEAFPNTDDAIIRAVLAASGYKLEPAFNALLGLSDPQVAEEMEQAETSYAYDTAAHDDPVQRQLEEDERCARELANRYNSHRPERRRKTNNDRRNYPPQNRTAKPNDNDGDDYSFFEDDLPVIKDTFMRGFQSFKQRSMEWVENIASKFDGEEEDDDDEKYSAPSKIYPSPRRSTAATLESAYEERPPSLPRRKPSRPGTAITLPPYESDPHMLNEKDFERLRLESSSSPMMRRSSLNSNRRSVESSSSAAFVEGQSFILDSNGAIEVANSAFALDDSDLESAYNEELEMKKDTSKPTASTKEVVVEKKPDESRKQAARTLETVSEEQMGSSNAKSKVLTSEPKDSTSVEAEKTETDEPAVGKGASDVSDTAEISEKTEAKNADSEANLEEKSDVGEEKESKDENNKASLHKDVEEKDTKITNEDTGKTETDVKAKETDSIEANDKDEKTDSKETEDKVEETESKEADVKAKETDSIEVDDKEEKTDSKETADKVEQTDSKDTNEKPAKDDNKEANEKAEKVDSKDVKEKIEEAADLQNSGKET
What are the official names of this protein?
CUE domain-containing protein 5.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPA_STRP3
Sequence: MAQGTVKWFNAEKGFGFISTENGQDVFAHFSAIQTNGFKTLEEGQKVAFDVEEGQRGPQAVNITKLA
What are the official names of this protein?
Major cold shock protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EGG2_CAEEL
Sequence: MSQQAGNAQRGRFDEEPMSLGEKISHRMDQLKEIVSSSCPCAGKFPPVAIVLIVALIILGVIIAVPLVIFLSPSAQAMSSGTRDLSSHSIRHPKVWPKTEKVQDDDLSAIQMTSLLPPNVSTCSGFGFACTGSIDMIIPSSKRCDGLKDCSDGSDEENCKECQSIYSCRAHIEEESEKKDKTSVLPTLICLTAEKLCNGVENCPDGSDEASCRSKCSKDQFKCSGSDACLPISVKCDGVSDCENESDESNCNKCQKGAHKCGKNCIKASKVCDGIPDCDDGSDEHQCDCKTCSGSEKALCEDGTCIMRSQVCDGKHDCLDGIDEENCPGSCSNERFSSKLKLLTCDDGNQYSEVEACSGLVEACELNCPKCDPKHTFTCPAVGGIHNKCIKRSKVCDGIFDCEDGADEKKCTPVKECVVESSIQFTCDNKCLESSRRCDGVWDCEDKSDEKGCDKCPSRSFKCSADKKCLPFHTRCNGVAECSDGSDEHKCSCQECLGTHHDTYMCSESNRCLKRGEVCSPYSMCPNATYIDKAYCASLALKNSGLRP
What is the function of this protein?
Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (PubMed:16360684, PubMed:20971008).  Redundantly with egg-1, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte (PubMed:16360684).  Conversely, shown to be dispensable for fertilization but required together with egg-1 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (PubMed:20971008).  Appears to recruit or maintain together to the unfertilized oocyte cortex several proteins including chs-1, kinase mbk-2 and pseudophosphatase egg-3, and possibly egg-4 and egg-5 (PubMed:20971008).
What are the official names of this protein?
LDL receptor repeat-containing protein egg-2, Egg sterile protein 2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Note=Localizes to the cell membrane of developing oocytes (PubMed:20971008). Plasma membrane localization requires extracellular matrix protein cbd-1 (PubMed:20971008). After fertilization, localizes to endosomes in zygotes (By similarity).
Protein: RUVB_GEODF
Sequence: MTRTITPDMTDDDLLEATLRPKSLDDYVGQEKAKGNLRVFIEAARGRGEALDHVLLYGPPGLGKTTLANIIACEMGVNIKSTSGPVIERPGDLAAILTNLETHDVLFIDEIHRLSHVVEEILYPAMEDFQLDIIIGQGPSARTIKLDLPKFTLVGATTRAGLLSSPLRDRFGVISRLEFYTIEELAFIITRSARILGMEIKPEGATELARRSRGTPRIANRLLRRVRDFAQVKADGVITLNVVQDALALLEIDHMGFDYMDRMILLTIIDKFGGGPVGLDTIAAAISEESDTIEDVYEPFLIQNGFLNRTPRGRVATRAAYEHFGRIVPEPPQGKLFQD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: TTL3B_TETTS
Sequence: MFSIDIQGKSMSLCDPTSKIKQMQQQQQQLQQGTNNGIQKDQQLPNMIINGNSNSYLNNGSNLQQQAVIQQSNHKQSQIKYNSPLSHQQHHQFKIGHQNKLEYLRQQQAQKYNQIYQLDPQLQQQNQMFQQHQYMQNVQMQQQLLYQGNQEVFPPFNQIANGSAQNSILLQQYLSNNKGQTNNSNRENGGNFHSEQSPKSAAGSVVSGNGSNTQFAANILRNSNIIQQQNEFRFQQIQQTHQLLHSLVQQQPQPLSQQHSNQSSQSSNPQSQSPLPLSISSQQPVISMANYFNQPSQQSNSLFNGQQPTMFNSSENFQQKNILYSCVGNPNNPYNHHINNPYLQEKRYYKSSKLPKIKKENKPQQAFSDIRPSSREKSARFHLAASINTILNQNGSTSVNTQNNENMVQTLKGHSYSAVTEKSNIGQQEVNIPTTSKTQTLIKEHSLTNINSASKENNQVTLASNSNQTSKKAYENLMSAENDEEDKLKCIRYFRYNLGQLLHILGKKEIYFSNLNSKKPIKTFASITQQLGQKHMNLLSKNTINIINKVKKIVATKGKYKYRERFNFLHSAQLKSINYDVRKRLNQIQDKKVLSNTKSKDEEESSDDDETPVKSKSNNQNAVQQTDLAKWKKYNRLDPKTKVFIIKGGYGDLRKALQERGWVENPDYFSPCFDLKWTCKVQDIDYDNLQENQVVNHFDNNQTFTSKYGLARNLRTLIHSENIDVYKFFPRCFDLGDLQEFEDFIENFKVAKAESLVHRFKDMLKNGIESIDDKLELKIRLCNEVASRKFIDFYETVDFIFNYDVLPCVSPEEWEIISKDEFQLDNKKIEFYLERLRSHPTFKHLYYSNSQSQKQHMNKRKNSHRISVNHNHNDPIEEESAQSSTSLKQDSLQRFSSKSQELLDLCNQTLKKSSEKDPQHHLNGYRNIWIVKPNFLSRGRGIKCFNSLDKIMDYVVGKETQFVVQKYIENPLLINNKKFDMRQWAIVQDFCPPRIWFFEECYIRLCSVEHNIDDLNNRFVHLTNNIVQKYNKDAYADKDDLMMSQEQFAQYLKETEGRDVFYEEIQPKLKQMVIQSLKSCQDQVGARKNSMEFIGYDFMIDSNYQPWLIEINSSPSMEYSTSITEELVQRVLQDTTKVIVDYSMAKKGTKKNVDTGGFKLIYKGEKQTKNNKVLASYKK
What is the function of this protein?
Polyglycylase which modifies tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of tubulin.  Polyglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin.
What are the official names of this protein?
Tubulin glycylase 3B.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Note=Mainly present in oral cilia.
Protein: OMPU_VIBCH
Sequence: MNKTLIALAVSAAAVATGAYADGINQSGDKAGSTVYSAKGTSLEVGGRAEARLSLKDGKAQDNSRVRLNFLGKAEINDSLYGVGFYEGEFTTNDQGKNASNNSLDNRYTYAGIGGTYGEVTYGKNDGALGVITDFTDIMSYHGNTAAEKIAVADRVDNMLAYKGQFGDLGVKASYRFADRNAVDAMGNVVTETNAAKYSDNGEDGYSLSAIYTFGDTGFNVGAGYADQDDQNEYMLAASYRMENLYFAGLFTDGELAKDVDYTGYELAAGYKLGQAAFTATYNNAETAKETSADNFAIDATYYFKPNFRSYISYQFNLLDSDKVGKVASEDELAIGLRYDF
What is the function of this protein?
Forms pores that allow passive diffusion of small molecules across the outer membrane.
What are the official names of this protein?
Outer membrane protein U, Porin OmpU.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: FLIW1_HELPJ
Sequence: MNYFLKAPILGFEHINEVRLEKIDSLFSRLMGQTNSPMALDMVLVNPYCLREYSFVIPKYIELLLELDSHSKVEVYCVVVLQKNLEDSMVNFLAPLVFNSKNGFGAQVALSMMDYPDFGFRDPLKSFVVKERERA
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW 1.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_RHOOB
Sequence: MSLDPAIASRLKRNEAGLFSAVAQERSTGDVLMVAWMDDEALARTLDTRKGTYYSRSRQQYWVKGETSGHTQYVHEVRLDCDGDTVLLVVDQEGAACHTGTHTCFDSDVLLAAD
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDG_ECOLI
Sequence: MKMIEVVAAIIERDGKILLAQRPAQSDQAGLWEFAGGKVEPDESQRQALVRELREELGIEATVGEYVASHQREVSGRIIHLHAWHVPDFHGTLQAHEHQALVWCSPEEALQYPLAPADIPLLEAFMALRAARPAD
What is the function of this protein?
Hydrolase with a preference for pyrimidine substrates.  Has high activity with 5-methyl-dCTP, and much lower activity with CTP, dCTP, 5-hydroxy-dCTP, 2-hydroxy-dATP and 8-hydroxy-dGTP.
What are the official names of this protein?
CTP pyrophosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.