PharMolix/UniProtQA huggingface dataset:
Protein: MURG_SYNE7
Sequence: MSVAQPRLLFAASGTGGHVFPALAVAEALPEAKIDWLGVPDRLETQLVGDRYPLHTIRVGGFQGSWLLRPLTALRLIGAIFKVRRLLKRQQIEAVFTTGGYIAGPAIAAAWSLGIPVVLHESNALPGKTTRLLSRFCRRVALGFAEAGEYLPGRPLQVVGTPLRSQFYQPSQHGLPIPENVPVLLVMGGSQGAVAINRLVRAAAPAWLAAGLWIVHLTGQQDPDRGQLQHPQYIELSFVDNVAPLLNRADFSISRAGAGSLAELAAAGLPSLLIPYPFAAEDHQTFNARIFAKAGAAILAPQSELTVEQLQQQILDLLRARLGAAIANPLPKMAAAAGKLHVADSAEQVANLLRSLL
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YFMD_BACSU
Sequence: MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSLKYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNAGASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHLFLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSVLGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEHYQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK
What is the function of this protein?
Part of the ABC transporter complex YfmCDEF involved in citrate-dependent Fe(3+) import.  Involved in the translocation of the substrate across the membrane (Probable).
What are the official names of this protein?
Fe(3+)-citrate import system permease protein YfmD, Ferric-citrate import system permease protein.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRF_COXBU
Sequence: MEKPDPKVIVAIDAGTVEQARAQINPLTPELCHLKIGSILFTRYGPAFVEELMQKGYRIFLDLKFYDIPQTVAGACRAVAELGVWMMNIHISGGRTMMETVVNALQSITLKEKPLLIGVTILTSLDGSDLKTLGIQEKVPDIVCRMATLAKSAGLDGVVCSAQEAALLRKQFDRNFLLVTPGIRLETDEKGDQKRVMTPRAAIQAGSDYLVIGRPITQSTDPLKALEAIDKDIKTR
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: LIGB_SALPC
Sequence: MRLWKSMAWGILLWHSQSGALCPAWPPARAAEEITRLQQQLADWNDIYWKQGVSAVDDSVYDQLSARLVQWQRCVGQDVSSTPVSPPLNGTTMHPVAHTGVRKLADRQAVEQWMRGRSELWVQPKVDGVAVTLVYQNGKLTRAISRGNGLQGEDWTPKIRLIPSIPQTTQGALANAVLQGEIFLQREGHIQQRMGGMNARSKVAGMLMRQDNASALNSLGIFIWAWPDGPANMPERLSQLAKAGFSLTNKYTLAVKDASEVERARQSWLTSALPFVTDGVVIRMAKEPASQHWRPGQGDWLAAWKYPPVAQVAQVSAIQFSVGKSGKITVVASLVPVILDDKRVQRVNIGSVKRWEAWDIAPGDQILVSLAGQGIPRLDEVVWRSRERSKPVPPDSHFNSLTCFYASATCQEQFISRLVWLGSRSALGLDGMGEASWRALHQTHRFEHIFSWLALTSAQIANTPGFAKGKSEQIWRQFNLARRQPFTRWIMAMDIPLTQAALQASGDRSWEQLLMRTEQHWRQLPATGERRAGRVIDWRDNPQIKTLSRWLAAQHIPGFGS
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Protein: PSBH_CHAGL
Sequence: MATKTIDNSIKLKGRRSAVGDILKPLNSEYGKVAPGWGTTVLMGVFMALFAVFLVIILEIYNSSVLLDGIPVSW
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H, Photosystem II 10 kDa phosphoprotein.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: LZTL1_MOUSE
Sequence: MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKDSRLVEETFTIDEVSEVLNGLQAVVHSEVESELINTAYTNVLLLRQLFSQAEKWYLKLQTDISELENRELLEQVAEFEKAEFVSSSKKPIIDITKPKLVPINEGGTTELLNKEILRLQQENEKLKSRLKTIEIQAVNALDEKSKLERVLQDLQLDQENQQDLLKAQDLDDLENTVATLRSEFQKTLNDKTENQKSLEENLAAAKHDLLRVQEQLSMAEKELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAKYESED
What is the function of this protein?
Regulates ciliary localization of the BBSome complex.  Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  May play a role in neurite outgrowth.  May have tumor suppressor function.
What are the official names of this protein?
Leucine zipper transcription factor-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the LZTFL1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCYD_ECO8A
Sequence: MPLHNLTRFPRLEFIGAPTPLEYLPRFSDYLGREIFIKRDDVTPMAMGGNKLRKLEFLAADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPNAQLEELATRVEAQGFRPYVIPVGGSNALGALGYVESALEIAQQCEGAVNISSVVVASGSAGTHAGLAVGLEHLMPESELIGVTVSRSVADQLPKVVNLQQAIAKELELTASAEILLWDDYFAPGYGVPNDEGMEAVKLLARLEGILLDPVYTGKAMAGLIGGISQKRFKDEGPILFIHTGGAPALFAYHPHV
What is the function of this protein?
Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives.  It could be a defense mechanism against D-cysteine.
What are the official names of this protein?
D-cysteine desulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: KCY_BUCBP
Sequence: MSFKNLVPVITIDGPSGVGKSSVCKVISKKLQWNVLESGWIYRVLAFIIFKNNVCFSSRNLNILFKNINLHDFIQRINFKNYVISQSLFTNISQEYIGNLASRLACIPYIRHFLLFQQRSFRKFPGLIANGRDMGTVVFPDAIIKFFLISDFKTRVARRCLEYEKKGINSCNYKKIFYDMKTRDQRDHNRKISPLIPAKNAILIDSTYMSLKQVSNVLLSYILKMQKFKL
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHG17_HUMAN
Sequence: MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGTDAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL
What is the function of this protein?
Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells.  Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state.  The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere.  Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments.  Acts as a GTPase activator in vitro for RAC1.
What are the official names of this protein?
Rho GTPase-activating protein 17, Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH-1.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.
Protein: EFTU1_YERPA
Sequence: MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGSARAFDQIDNAPEEKARGITINTSHVEYDTPARHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRELLSAYDFPGDDLPVVRGSALKALEGEAEWEAKIIELAGYLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDTVKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREDIERGQVLAKPGSIKPHTTFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNINMIVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 1, EF-Tu 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FENR2_BACVZ
Sequence: MQEDSKVYDITVIGGGPVGLFTAFYGGMRQASVKIIESLPQLGGQLSALYPEKYIYDVAGFPKIRAQELVNNLKEQMAKFDQTICLEQAVESVEKQADGVFKLVTNSETHYSKTVIITAGNGAFKPRKLELESAEQYEGKNLHYFIDDLNQFAGRRVAVLGGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHNSKVNVLTPFVPAELVGEDRIEQLVLEEVKGDRKEIIEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETNIEGFFAAGDICTYEGKVKLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSMFEK
What are the official names of this protein?
Ferredoxin--NADP reductase 2, FNR 2, Fd-NADP(+) reductase 2.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: YMF19_RAPSA
Sequence: MPQLDKFTYFSQFFWLCLFFFTFYIFICNDGDGVLGISRILKLRNQLLSHRGKTIQSKDPNSLEDLLRKGFSTGVSYMYASLFEVSQWCKAVDLLGKRRKITLISCFGEISGSRGMERNILYNISKSSPSNTGRWITCRNCRNDIMLIHAVHGQGSIK
What is the function of this protein?
This is one of the chains of the nonenzymatic component (CF(0) subunit) of the mitochondrial ATPase complex.
What are the official names of this protein?
Putative ATP synthase protein YMF19, Mitochondrial protein YMF19.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein YMF19 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: PNCB_BURCM
Sequence: MIITSLLDTDLYKFTMMQVVLHHFPAANVEYRFRCRTPGVDLVPYIDEIRDEVRGLCSLRFTDVELDYLRRMRFIKSDFVDFLALFHLNEKYISITPSPKGNGEIDIVIEGPWLHTILFEIPVLAIVNEVYFRNTQREPDYREGRERLREKIKLLGAKPEFADCKIADYGTRRRFSKVWHEEVALTLRDGLGPQFAGTSNVFYAMKHELTPLGTMAHEYLQACQALGPRLRDSQTYGFEMWAKEYRGDLGIALSDVYGMDAFLNDFDMYFCKLFDGARHDSGDPFEWGERMLRHYEANRCDPRTKVLVFSDALDIPKVMQLYERFRNRCKLAFGVGTNLTNDLGYVPLQIVIKMVRCNGQPVAKLSDSPGKSMCDDRAYLAYLRQVFGIAQPADDDASQ
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: ZUPT_CORGL
Sequence: MLFAFGLTLFAGLATGIGGLIAVARKTVTEGFLAGSLGFSVGVMLYVSFVEILPGAFDELTSVWGEKGGSWAAVIGFFGGIALIAIIDRLVPTAINPHEPSTVGGAVEGFERRNRMMKMGVLTALAIAIHNFPEGFATFLAGLSDPMIAIPVAVAIAIHNIPEGIAVAVPLREATGSRRKALGWATLSGLAEPAGALIGFLLLMPFIGPEALGLCFAAVAGVMVFISVDELLPTAISSGKHHTAIYGLIAGMAVMAISLLLFI
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MENB_SALTY
Sequence: MIYPDETMLYAPVEWHDCSEGYTDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNVGVIILTGEGDKAFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP
What is the function of this protein?
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA synthase, DHNA-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
Protein: GLMU_LEGPH
Sequence: MNLQIIILAAGQGKRMYSDTPKVLHHLAGKPLLTHVVETAQQLNPNAIHVIYGHGGEQIKSSLPNLPVHWVHQAEQLGTGHAVLQAMPHIPDDAYVLVLSADVPLIQVETLQSLIECSQRQNPDHSVLALLVAELENPSGLGRIIRNNQGEIYSIVEEKDANEQVKNIKEIYSGVCCTLANNLKKWLPQLSNSNAQGEYYLTEIISLAVQNKTPITSLTAKNSFEVQGINNRQQLQQLERIWQQRAANQLMEKGATLADANRFDLRGELYCGKDVYIDINCIFTGKVVLGNGCKIGPNCSLTNVTLGDGCEVYANSVLEGCHIANDCHIGPFARLRSGTQLASHCKIGNFVETKKAIFDEGTKASHLSYLGDVLLGKNVNVGAGTITCNYDGVNKHQTIIEDGVFIGSDTQLIAPVTVGANATIGAGSTIRRNVPPDELTLTESRQKTIYGWKRPVKRERD
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_ARTOB
Sequence: MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLGVCLGVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWLLRYLHANGASMFFICLYLHVGRGLYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVTALVMVHLPFLHETGSNNPTGIPSDPDMIHSHPYYTIKDILGFLVMLTALASLVLFSPDLLGDPDNYIPANPLITPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIVPILHMSKQRSMMFRPLSQCLFWLLVAVLFTLTWIGGQPVEHPYIIIGQTASTLYFLIILFLMPMISLVENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PABR1_PALRI
Sequence: GGSVPCGESCVFIPCITSLAGCSCKNKVCYYD
What is the function of this protein?
Probably participates in a plant defense mechanism.  Reduces growth of and increases mortality in larvae of D. saccharalis.  Kills cultured SF-9 cells of S. frugiperda probably by disrupting plasma membranes.  Has hemolytic activity against human erythrocytes.  Has no antibacterial activity against E. coli strain ATCC 8739 and S. aureus strain ATCC 25923.
What are the official names of this protein?
Parigidin-br1.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: YKT6_HUMAN
Sequence: MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSSKGTRASVKEQDYLCHVYVRNDSLAGVVIADNEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM
What is the function of this protein?
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment.  Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5.  Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5.  Has a S-palmitoyl transferase activity.
What are the official names of this protein?
Synaptobrevin homolog YKT6.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.
Protein: HIS1_LISW6
Sequence: MKALKIALTKGRLERDAVALLKKAGIDCSSMLDKKRKLIFHSNSQPVSFILVKAVDVMTYVKHGVADIGIVGKDVLMEASKSHYEMLDLEIGKCQFCLASTPDFDPSNYRRKIIATKYPTVASKFFREKGEDVEIIKIEGSVEIAPVLGLADAIIDIVETGSTLKENGLLIYEKMYPISARLIVNKASLKQNKTQIFQLIDQLEQAIKEERTK
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADA_PSEOL
Sequence: MSLNPRDVVIVDFGRTPMGRSKGGMHRNTRAEDMSAHLISKLLERNDKVDPKEVEDVIWGCVNQTLEQGWNIARMASLMTQIPHTSAAQTVSRLCGSSMSALHTAAQAIMTGNGDVFVVGGVEHMGHVSMMHGVDPNPHLSLHAAKASGMMGLTAEMLGKMHGITREQQDLFGLRSHQLAHKATVEGKFKDEIIPMQGYDENGFLKVFDFDETIRPETTLEGLASLKPAFNPKGGTVTAGTSSQITDGASCMVVMSGQRAMDLGIQPLAVIRSMAVAGVDPAIMGYGPVPSTQKALKRAGLTMADIDFIELNEAFAAQALPVLKDLKVLDKMDEKVNLHGGAIALGHPFGCSGARISGTLLNVMKQNGGTLGVATMCVGLGQGITTVFERI
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPS1_ORYSJ
Sequence: MAAAPQQSVHPSLPSSTSTLRLLISSSPRRPPPPPPRARRYNRLAASASAAREMPWPHVLTVAGSDSGGGAGIQADIKACAALGAYCSSVVTAVTAQNTAGVQGIHVVPEEFIREQLNSVLSDMSVDVVKTGMLPSIGVVRVLCESLKKFPVKALVVDPVMVSTSGDTLSESSTLSVYRDELFAMADIVTPNVKEASRLLGGVSLRTVSDMRNAAESIYKFGPKHVLVKGGDMLESSDATDVFFDGKEFIELHAHRIKTHNTHGTGCTLASCIASELAKGATMLHAVQVAKNFVESALHHSKDLVVGNGPQGPFDHLFKLKCPPYNVGSQPSFKPDQLFLYAVTDSGMNKKWGRSIKEAVQAAIEGGATIVQLREKDSETREFLEAAKACMEICKSSGVPLLINDRVDIALACNADGVHVGQLDMSAHEVRELLGPGKIIGVSCKTPAQAQQAWNDGADYIGCGGVFPTSTKANNPTLGFDGLKTVCLASKLPVVAIGGINASNAGSVMELGLPNLKGVAVVSALFDRPSVVAETRNMKSILTNTSRT
What is the function of this protein?
Essential for thiamine biosynthesis.  Bifunctional enzyme that catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP and condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Probable thiamine biosynthetic bifunctional enzyme, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLPS_BRUMB
Sequence: MRRFNTIMQGKTNGGNGPESGTVVVTRTQPKTRKPSLYRVLLLNDDYTPMEFVVHVLQRFFQKNLDDATRIMLHVHNHGVGECGVFTYEVAETKVSQVMDFARQNQHPLQCVMEKK
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: SPD18_HUMAN
Sequence: MDRTKTRFRKRGQITGKITTSRQPHPQNEQSLQRSTSGYPLQEVVDDEVLGPSAPGVDPSPPCRSLGWKRKKEWSDESEEEPEKELAPEPEETWVVEMLCGLKMKLKQQRVSPILPEHHKDFNSQLAPGVDPSPPHRSFCWKRKREWWDESEESLEEEPRKVLAPEPEEIWVAEMLCGLKMKLKRRRVSLVLPEHHEAFNRLLEDPVIKRFLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEDPKQNIFYFLYGKTRSRIPLVRNRRFQLCRCLNPRARKNRSQIALFQKLRFQFFCSMSGRAWVSREELEEIQAYDPEHWVWARDRARLS
What are the official names of this protein?
Speedy protein E18.
What is the protein family that this protein belongs to?
Belongs to the Speedy/Ringo family.
Protein: RRAA_VIBPA
Sequence: MEYNTSALCDIYLDQVDVVEPMFSNFGGRASFAGQITTIKCFEDNSLIRETLEQDGLGRVLLIDGGGSLRKALIDAEIAAIAEENEWEGIVVYGCVREVDELEDMNLGIQALASIPVGAANQGIGELDVPVNFGGVSFLPEDYIYADNTGIILSPEPLNIDLELDDTVEE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_CHLAD
Sequence: MPFRIEAPYQPTGDQPQAIEKLVAGLRAGYRHQTLLGATGTGKTFVMAHIFAQIQRPTLVLAHNKTLVSQLWAEFREFLPDAAVEMFISYYDEYTPEAYVPSKDLYIEKEASINEEIDRLRHAATQALLTRRDVLIVASVSAIFGLGSPHDYGQEKIHLRTGEVRNRDKLLRQLIDLQFERNDVDFQRGTFRVRGDTLDIIPANAETAIRVEFWGDEIERIVELDPLTGEVLLKHTAVEIYPAKHFVTTKEKLQLAIVSIQAELNERLQELEAAGKLLEAQRLKQRTLYDLEMLSEVGYCSGIENYSRHLDGRAPGQTPWTLLDYFPDDFLMFIDESHITIPQLRGMYNGDRQRKQTLVDYGFRLPSALDNRPLKFEEFEQHVYQVIYVSATPGPYEREKSEQIVEQIIRPTGLLDPEIEVRPTRGQIDDLLGEIRRRVERKQRVLVTTLTKRMAEDLADYLKEMGVRTMYLHADIDTIERVEILRDLRLGVYDVVVGINLLREGLDLPEVSLVAILDADKEGYLRSETSLIQIIGRAARHIEGKVIMYADTITRSMEVAIRETQRRREIQMAHNVRHGITPQGIAKGVRDLTDRIRKVAEERGEYVTTPETAVPVDLPRDEVLKLIKDLEKQMKQAAKALAFEKAAALRDQIVELRQALALSE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFH_HALHL
Sequence: MSSEGELGIEVVYALPGQQTVLRVELPAGSTAGDALNASGVLERHPEIDLTRQSVGVFGQIVGLDTPLHNGDRVEVYRPLQVDPKEARKRRAARKAS
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.