PharMolix/UniProtQA huggingface dataset:
Protein: ANXA2_MOUSE
Sequence: MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
What is the function of this protein?
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids.  It binds two calcium ions with high affinity.  May be involved in heat-stress response (By similarity).  Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:22848640).
What are the official names of this protein?
Annexin A2, Annexin II, Annexin-2, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, Lipocortin II, Placental anticoagulant protein IV, PAP-IV, Protein I, p36.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane.
Protein: CF144_BOVIN
Sequence: MAGHQKEKAIADEVHQNQILRELYLKELRTQKLYTQYHVNPLRKVHTIARKPMSWHDNLEEPADARFLNLIHHAAQGPRKKYPETQTEGQEIGWDSEPLVNPQRDDRRLNHFRVYKDITLYKAKMWSLGEDDRHK
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
What are the official names of this protein?
Cilia- and flagella-associated protein 144, Protein FAM183A.
What is the protein family that this protein belongs to?
Belongs to the CFAP144 family.
Protein: VIRB7_RHIRD
Sequence: MKYCLLCLVVALSGCQTNDTIASCKGPIFPLNVGRWQPTPSDLQLRNSGGRYDGA
What is the function of this protein?
Is essential for the biogenesis of the T-pilus, which is required for virulence and T-DNA transfer to plant cells.  When is associated with virB9, might function as a nucleation center for recruitment of VirB proteins during assembly of the T-DNA transfer machine.
What are the official names of this protein?
Outer membrane lipoprotein virB7.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Note=Also associated with the T-pilus when is a homodimer, possibly at the pilus base.
Protein: C3H28_ORYSJ
Sequence: MASAETPNPDAEIPNTDAAAAADPAAAAPAAAATDPAAAGSPSPPLPPRKRRLSPTPSPTRRSSRSRSRSPRRGRSRSRSRSRSRGRSASPRYPDGKRRRHNDLNVEVCRDFLRDRCARADIECKYAHPHPTVAVDRDSKVTACADSLRNNCFRGRTCRYYHPPPHIQESLLRSIGVEDPKVKMQVCRDFTRGRCSRSANECRFLHHSPLEDCAIVCQDFLRGRCDRKSCRYSHVMAHPMPPPMRDIPMQYPDMVYMPPPAPLGVPMMMPPPSAPAAFSGNNYGVEVCRDYLKNMCNRESCRFAHPDLNNEVMNTQVEVCRDFKRGECNRPACRFYHPPASSNSIG
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 28, OsC3H28.
Protein: GATA_CAUVN
Sequence: MSLTNLTLKAAIDGLAAREFTSVELTRAHIEAIEAARGLNAYILETPDKAIDMAAKSDARRALGEAGPLEGAPLGVKDLFCTNGVRTTACSKILENFVPTYESTVTSQLWRDGAVMLGKLNLDQFAMGSSNETSYFGPVTNPWRAQGSTKALTPGGSSGGSAAAVAADLCLGATATDTGGSIRQPAAFTGTVGIKPTYGRCSRWGVVAFASSLDQAGPIAKTVEDAALLLTSMSGHDPKDSTSLDIPVPDFTQFVGKSVKGLKIGIPKEYRVDNMPAEIEKLWQDGIAWLKEAGCEIVDISLPHTKYALPAYYIVAPAEASSNLARYDGMRYGLREEGANLTEIYENTRASGFGDEVKRRILIGTYVLSAGYYDAYYLKALKVRRRIAEDFDNAWTQCDAILTPTAPSAAFGLGENSNDPIAMYLNDVFTVTTNLAGLPGLSLPAGLDANGLPLGLQIIGKPLDEATVFSVAGAVEKAAGFTAKAEKWW
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: NO75_LUPLU
Sequence: SPPVHPPPHEKPPIVHPPPHEKPPLFEPPFEKPPPAHPPPVHPPPHEKPPIEYPPPHTKPPIEYPPPHVKPPIQYPPPHEKPPIEYPLPHEKPPVYEPPYEKPPPVHPPPHEKPPIEYSPPHEKPPVHEPPYEKPPLVHPPPHDKPPIEYHPPHEKPPIEYPPPHEKPPIEYPPPHEKPPIEYPPPHEKPPVYEPPYEKPPPVHPPPDEKPPIEYPPPLEKPPVHEPPYEKPPPAQPPPHDKPPIEYPPPHEKPPVYEPPYERSPPVHPPSHEKPPFVYPPPHEKSPMHEPPYEKAPPVHLPPHEKPPIEYAPPHEKPPVEYPPPHVKPPVEYPSPAEKPPTHEKPPIEFPPHEKPPVYEPPYEKPPSVCPPPHEKPPHHEKRSALYPPHHRKPPNHHKPLPYKKPPFYKSPPVEKPSSYESQPYGRLPVLPEK
What is the function of this protein?
Involved in early stages of root nodule development.
What are the official names of this protein?
Early nodulin-75, N-75, NGM-75.
What is the protein family that this protein belongs to?
Belongs to the nodulin 75 family.
Protein: PDXH_PSYA2
Sequence: MNMDFTDQRLSYEKGQLDQQSVPISPFELLKAWMHEAIEEQVQEPYAMSLATCGADDKPSVRIVLLREITDKGIVFYTNYESAKGQDIAENPNAEALFFWHKLERQIRISGSIAKIDADKSAAYFQKRPHDSQVGTWVSQPQSGEVASRDVMEQTFEQLQTDYPDGAAVPTPGFWGGYEITVSEIEFWQGRANRMHDRIVYHKEVDGSFSTKRLLP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: KDKA_ACTSZ
Sequence: MLEIRQNHCFYLFNWDEPRQDQTRFFSPEFWRRQGRISGTAQGRGITWFLQTVDLFGVNAALRHYYRGGLWGKINRDRYTFTSLENTRSFAEFRLLSRLHQAGMPVPKPLAAKVEKLSLGGYRADILTEKVENARDLTALLQTENLSDEAWRQIGKLIRRLHDLQICHTDLNAHNILVQQVKEQEKYWLLDFDKCGEKSGDFWKAQNLARLKRSFLKEAARMGIRFTEGDWKNLLKGYQN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
What are the official names of this protein?
3-deoxy-D-manno-octulosonic acid kinase, Kdo kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. KdkA/RfaP family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RPO12_HALSA
Sequence: MSYKCSRCKRDVELDEYGGVRCPYCGHRVLLKERSRDVKEVSVQ
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo12, DNA-directed RNA polymerase subunit P.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2XA_DICDI
Sequence: MGFSFDWDDIFQYSTVKIVRIRDRRLGILHLSFLVGIVAYIVVYSAIIKKGYLFTEVPIGSVRTSLKGPNTFASNLTYCSNQQHNGSTYPFTPLECNYWDEQLALFPVGQDSTFTCTTRVRLSKQEANCNFTDPTCKFVDEPGSAKNIYIADIESFTILIDHTMYASSSGSQFNAVDLHGYILNQDGDEVQIDANGTSIGVSGKPDIMTIGQLLSFGGVSLDQASPVDSNVSIRYDGVVLFVFITYSNTYTYSTSDFKYVYSVQQIANTIYDVPETIILESIHSRLLYKRHGIRVIFIQTGTIGSFHFQTLLLTLVSGLGLLAVATTVVDQLAIRLLPQRKSYSSLKFQVTESMSNPMKKRITTDEGEDVLYTRIEGL
What is the function of this protein?
P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling.  Not required for the purinergic response to extracellular nucleotides.  Inward currents evoked by intracellular ATP and ATP analogs.  Exclusively selective for ATP over other nucleotides.  Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion.  More permeable to ammonium than either sodium or potassium ions and less permeable to choline.  It has been reported that p2xA is not essential for osmoregulation (PubMed:19833731), however this information is in contradiction with another source (PubMed:17625565) which indicates that p2xA is required for osmoregulation.  Found to be permeable to chloride ions.  Inhibited by copper and sodium ions.
What are the official names of this protein?
P2X receptor A, DdP2X, P2XA.
What is the protein family that this protein belongs to?
Belongs to the P2X receptor family.
Protein: FMCD_PSEAI
Sequence: MKAQKGFTLIELMIVVAIIGILAAIAIPQYQNYVARSEGASALATINPLKTTVEESLSRGIAGSKILIGTTASTADTTYVGIDEKANKLGTVAVTIKDTGDGTVKFTFATGQSSPKNAGKEITLNRTAEGVWTCTSTQEEMFIPKGCNKP
What are the official names of this protein?
Fimbrial protein, Pilin.
What is the protein family that this protein belongs to?
Belongs to the N-Me-Phe pilin family.
What are the subcellular locations of this protein?
Fimbrium. Membrane; Single-pass membrane protein.
Protein: HEM1_LEIXX
Sequence: MLICFSSSHRTAAFDLLDQLERHAPAVATALAEHSELVTGSVVLATCNRFEAYLDIDEPLPAARAVSAETVIAAVGNAAGIDADLLRSSSRVYCDDAAAEHLLSVSSGLDSVVVGEGEIAGQVRRALTTARQAGTVSQDLERLFQVASRTSRGVKNRTGIATAGRSIVRLALDLAESRVSDWSRMRVLLIGTGKYAGASLAALRDRGVADVQVHSPSGRAEKFALSHGVTAVPAGGLGAALAHAHLIVTCTTVRDYTLTPGNFGQAQQQDGIERRLVIDLGLPRNVDSAVAELPGVELLDLETISLHAPVAELNAADDAREIVGAAAAEFAAQTAEQAVKPALIALRKHVFDILDAEIARARTRGDSSEQTEAALRHLAGVLLHTPSVRARELARAGDAQRFADAAETLFGLRIEEAPVHPRLIAVDRVTAS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: REP_MISV9
Sequence: MRAPASSAASNRPGPSNHPTPRWNSKQFFLTYPHCNLTPSELMKELFSRLTEKIPGYIKVSQEFHKDGDPHLHVLIQLNTKLCTRNPKFFDVQGFHPNIQPVRDAEKVFGYISKTNGDSDEMGELQLRIKKPEKPTRDQRMAMIIASSTNRNEYLSMVRKEFPFDWAIRLQQFEYSAAALFTEPPPVYQSPFPNEQIVCPPELVDIIDQEWNQQPNGPRRPRSIYICGPSRTGKTTWARNIGRHNYYNSTVDFTHYDKDAIYNVIDDVPFKFLPQWKALVGAQRDYIVNPKYGKKKKIPGGIPSIILTNDDEDWIKDMKPAQVEYLHANAHVHYMYEGQKFYVLPAEE
What is the function of this protein?
Essential for the replication of viral ssDNA.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific region at the genome origin of replication.  It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities.  Acts as an inhibitor of C-sense gene transcription (By similarity).
What are the official names of this protein?
Replication-associated protein, Rep.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ZNF14_HUMAN
Sequence: MDSVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLGKKWEDQDIEDDHRNQGKNRRCHMVERLCESRRGSKCGETTSQMPNVNINKETFTGAKPHECSFCGRDFIHHSSLNRHMRSHTGQKPNEYQEYEKQPCKCKAVGKTFSYHHCFRKHERTHTGVKPYECKQCGKAFIYYQPFQRHERTHAGQKPYECKQCGKTFIYYQSFQKHAHTGKKPYECKQCGKAFICYQSFQRHKRTHTGEKPYECKQCGKAFSCPTYFRTHERTHTGEKPYKCKECGKAFSFLSSFRRHKRTHSGEKPYECKECGKAFFYSASFRAHVIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSISLRLHERTHTGEKPYECKQCHKTFSFSSSLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERTHNAEKPYECKQCGKAFRCSSYFRIHERSHTGEKPYECKQCGKVFIRSSSFRLHERTHTGEKPYECKLCGKTFSFSSSLREHEKIHTGNKPFECKQCGKAFLRSSQIRLHERTHTGEKPYQCKQCGKAFISSSKFRMHERTHTGEKPYRCKQCGKAFRFSSSVRIHERSHTGEKPYECKQCGKAFISSSHFRLHERTHMGEKV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 14, Gonadotropin-inducible ovary transcription repressor 4, GIOT-4, Zinc finger protein KOX6.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EIF3G_ASHGO
Sequence: MSEVPEPRIIENPDGSKTIISFKIDGGKKLKITQRVKEIKITEKVNKSIAERRKWAKYGAEAGSGPGPNLSTTKLAEELQLRLAPSLKEVREQDSKEKEKEKQEGEKSLYVCRTCGIPGHFTTKCPFRDILGEMSGPAEGEGGLDAAVDTAMPAASAPGKYVPPSRRAGGRDPSSDVYKDQRERDDAMTLKIMQLNENADEMTIKQKLLSPFPNVPRVAVVRNKETGRSRGIAYVTFASEKDAETALRLLHGRGFMNLILQVDWSKPKK
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  This subunit can bind 18S rRNA.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit G, eIF3g, Eukaryotic translation initiation factor 3 RNA-binding subunit, eIF-3 RNA-binding subunit, Translation initiation factor eIF3 p33 subunit homolog, eIF3 p33 homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit G family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROF_ECTVM
Sequence: MAAEWHKIIEDVSKNNKFEDAAIVDYKTKKNVLAAIPNRTFAKIIPGEVIALITNRNILKPRIGQKFFIVYTNSLMDENTYTMELLTGYAPVSPIVIARTHTALIFLMGKPTTSRREVYRTCRDYATNVRATGN
What is the function of this protein?
Participates in either intracellular transport of viral proteins or intercellular spread of the virus.  Cellular profilins modulate actin filament dynamics (polymerization and depolymerization) via direct binding to actin through an actin-binding domain as well as by modulation of other actin-binding proteins.  In contrast to cellular homologs, the poxvirus profilins seem to bind actin only weakly.
What are the official names of this protein?
Profilin.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Localizes to inclusion bodies formed by viral A25/ATI protein in the cytoplasm of the host cell.
Protein: BEX2_RAT
Sequence: MESKVEQGVKNLNMENDHQEKEEKEEKPQDANKREPVVALPFEAGEYYVPRGSRRRFRVRQPIAHYRWDLMHRVGEPQGRMREENVQRFGEDMRQLMEKLRERQLSHSLRAVSTDPPHHDHHDEFCLMP
What is the function of this protein?
Regulator of mitochondrial apoptosis and G1 cell cycle.  Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity).
What are the official names of this protein?
Protein BEX2, Brain-expressed X-linked protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the BEX family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RPTOR_HUMAN
Sequence: MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAERTDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPATTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGNLSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTADDADDAAGHKSFISATVQTGFCDWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKRVR
What is the function of this protein?
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates.  mTORC1 is activated in response to growth factors or amino acids.  Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1.  Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases.  Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis.  mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).  mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.  Involved in ciliogenesis.  mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity).
What are the official names of this protein?
Regulatory-associated protein of mTOR, Raptor, p150 target of rapamycin (TOR)-scaffold protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RAPTOR family.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome. Cytoplasmic granule. Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.
Protein: RS15_CLOB1
Sequence: MDKAKKQELMAKHARHEGDTGSPEVQIALLTERINHLNSHLKEHKKDHHSRRGLLMMVGKRRGLLNYLMREDIERYRAIIKELGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: IMG1_YEAST
Sequence: MWSRNVRLLGSWTRSYMVPATKRKTIPVYPPVQRIASSQIMKQVALSEIESLDPGAVKRKLISKKNKDRLKAGDVVRIVYDSSKCSYDTFVGYILSIDRKQLVQDASLLLRNQIAKTAVEIRVPLFSPLIERIDLLTPHVSSRQRNKHYYIRGTRLDVGDLEAGLRRKK
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:24675956).  bL19m is essential for respiration (PubMed:8771712).
What are the official names of this protein?
54S ribosomal protein IMG1, mitochondrial, Integrity of mitochondrial genome protein 1, Mitochondrial large ribosomal subunit protein bL19m, PetCR46.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: KSHB_MYCTU
Sequence: MTEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSPYTDDALAVTVKRTADGYASNWLCDHAQVGMRIHVLAPSGNFVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLLYANRDDRSVIFGDALRELAAKYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVPAQQVHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLDAPFSCREGHCGACACTLRAGKVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE
What is the function of this protein?
Involved in the degradation of cholesterol.  Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A.  KSH is also able to use 4-androstene-3,17-dione (AD), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4-BNC), 3-oxo-23,24-bisnorcholesta-4-en-22-oyl-coenzyme A thioester (4-BNC-CoA) and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) as substrates.
What are the official names of this protein?
3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component, 3-ketosteroid-9-alpha-hydroxylase, ferredoxin reductase component, KSH, Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase, Rieske-type oxygenase, RO.
Protein: U2AF2_MOUSE
Sequence: MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLVSLPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
What is the function of this protein?
Plays a role in pre-mRNA splicing and 3'-end processing.  By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing.  Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene.  Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals.
What are the official names of this protein?
Splicing factor U2AF 65 kDa subunit, U2 auxiliary factor 65 kDa subunit, U2 snRNP auxiliary factor large subunit.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HISX_SALPA
Sequence: MSFNTLIDWNSCSPEQQRALLTRPAISASDSITRTVSDILYNVKTRGDDVLREYSAKFDKTEVTALRVTPEEIAAAGARLSDELKQAMAAAVKNIETFHSAQTLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPARIAGCQKVVLCSPPPIADEILYAAQLCGVQEIFNVGGAQAIAALAFGSESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPDADIARKVAEAVERQLAELPRADTARQALSASRLIVTKDLAQCVAISNQYGPEHLIIQTRNARDLVDAITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKAGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: PGXC_ASPNG
Sequence: MSVFKASFLFLLSSSLVHGVPHSSRASRSQQCVVPSKYQASNGMADDSVAVSQAFAQCATDSVIIFEEGVNYNIFQPITATNLSNVEIRMHGNLHLPQNITAVQNIVSDGTSTWFTLEGPKVDWIGPEDVNNGWIDSYGQPWWDANPAGSSGIDNRPHLMSFKSSQATMKYFRSRKPIAWNVKLHGQDITVSHAIIDATSTGSFPFNTDGFDVEGTNIQITDSIMYNGDDAIAVGADSHDTLFTRNTIGYQTHGMSIGSLGKDPTDFANISNIRFDDVTVVDGLYAARFKSWSGGTGLVKNVTWNNIRVFNVTFPIFVTQSYSDQGASRSGTVNASSAVMMEDFTWSDFAGSINTYQPGDGSCVSDPCWYNVGLPNLKHTEALIIECHTAQSCKNFVTDNIQLYPQVLEPASVICMNATAALNPDLGFTCKNGTYSPLSN
What is the function of this protein?
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
What are the official names of this protein?
Exopolygalacturonase C, Galacturan 1,4-alpha-galacturonidase C, Poly(1,4-alpha-D-galacturonide)galacturonohydrolase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.