PharMolix/UniProtQA huggingface dataset:
Protein: IF2B2_HUMAN
Sequence: MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK
What is the function of this protein?
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs).  This transcript 'caging' into mRNPs allows mRNA transport and transient storage.  It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity).  Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152).  Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060).  Binding is isoform-specific.  Binds to beta-actin/ACTB and MYC transcripts.  Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152).
What are the official names of this protein?
Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2.
What is the protein family that this protein belongs to?
Belongs to the RRM IMP/VICKZ family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Protein: HEC3_ARATH
Sequence: MNNYNMNPSLFQNYTWNNIINSSNNNNKNDDHHHQHNNDPIGMAMDQYTQLHIFNPFSSSHFPPLSSSLTTTTLLSGDQEDDEDEEEPLEELGAMKEMMYKIAAMQSVDIDPATVKKPKRRNVRISDDPQSVAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRLLNNNTGYTPPPPQDQASQAVTTSWVSPPPPPSFGRGGRGVGELI
What is the function of this protein?
Required for the female reproductive tract development and fertility.
What are the official names of this protein?
Transcription factor HEC3, Basic helix-loop-helix protein 43, AtbHLH43, bHLH 43, Protein HECATE 3, Transcription factor EN 119, bHLH transcription factor bHLH043.
What are the subcellular locations of this protein?
Nucleus.
Protein: UBE2Z_XENTR
Sequence: MAESPAAEAIILPGAAAGGGVLPHLSGLQAPGTSPLTTSSVWDPTASADWDNERASNQCVLRIKRDIMSIYKEPPPGMFVVPDPHDMTKIHALITGPFDTPYEGGFFLFLFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSLSSVLISIQSLMTENPYHNEPGFEQERHSGDSKNYNECIRHETIRVAVCEMLEGKCQCPDALRSVMEKSFMEYYDFYEAVCKDRFHLQGQNMQDPFGEKRGHFDYQSLLSRLQTIHQRVREKHRKETVDIDSDSSSSETETDTQGSSNP
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  May be involved in apoptosis regulation.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 Z, E2 ubiquitin-conjugating enzyme Z, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YIP4_YEAST
Sequence: MSYGREDTTIEPDFIEPDAPLAASGGVADNIGGTMQNSGSRGTLDETVLQTLKRDVVEINSRLKQVVYPHFPSFFSPSDDGIGAADNDISANCDLWAPLAFIILYSLFVSHARSLFSSLFVSSWFILLVMALHLRLTKPHQRVSLISYISISGYCLFPQVLNALVSQILLPLAYHIGKQNRWIVRVLSLVKLVVMALCLMWSVAAVSWVTKSKTIIEIYPLALCLFGMAWLSTIL
What is the function of this protein?
May be involved in proper membrane localization of Rab GTPases.
What are the official names of this protein?
Protein YIP4, YPT-interacting protein 4.
What is the protein family that this protein belongs to?
Belongs to the YIP1 family.
Protein: GLRX2_CWPXG
Sequence: MKNVLIIFGKPYCSICENVSEAVEELKSEYDILHVDILSFFLKDGDSSMLGDVKRGTLIGNFAAHLSNYIVSIFKYNPQTKQMAFVDINKSLDFTKTDKSLVNLEILKSEIEKANYGVWPPVTE
What is the function of this protein?
Glutaredoxin necessary for virion morphogenesis and virus replication.  Functions as a thiol-disulfide transfer protein between membrane-associated OPG128 and substrates OPG095 or OPG053.  The complete pathway for formation of disulfide bonds in intracellular virion membrane proteins sequentially involves oxidation of OPG072, OPG128 and OPG088.  Exhibit thioltransferase and dehydroascorbate reductase activities in vitro.
What are the official names of this protein?
Glutaredoxin-2.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: NCAP_I63A2
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYVQMCTELKLSDHEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIMRIWRQANNGEDATAGLTHLMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIQMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLTVASGYDFEREGYSLIGIDPFKLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSNFIRGTKVVPRGQLATRGVQIASNENMETMDSCTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMENARSEDVSFQGRGVFELSDEKATNPIVPSLDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RL17_COREF
Sequence: MPTPKKGARLGGSASHQKKILSNLAASLFEHGAIKTTDAKAKTLRPYAEKLITKAKSGTVADRRNVLALIPNKDIVAYLFDELAPKFENRAGGYTRIIKLENRKGDNAPMSQISLVLEETVSAEATRAARAAASKQTADEAQVEETPAEEVTEETAAEETTEAAQADEAPAEEAPVEEKKDEEK
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: KDPC_SALDC
Sequence: MIGLRPAFSTMLFLLLLTGGVYPLLTTALGQWWFPWQANGSLIHKDNVIRGSALIGQSFTAAGYFHGRPSATADTPYNPLASGGSNLAASNPELDAQIQSRVAALRAANPQASSAVPVELATASASGLDNNLTPGAAAWQIPRVAAARQLPVEQVAQLVAEYTHRPLARFLGQPVVNIVELNLALDALQGHRAK
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MAST1_VESVU
Sequence: INWKKIKSIIKAAMN
What is the function of this protein?
Chemotactic peptide for polymorphonucleated leukocytes (PMNL), but causing no hemolysis to erythrocytes and no mast cell degranulation activity at physiological concentrations.  Potent antimicrobial peptide against Gram-positive and Gram-negative bacteria (By similarity).
What are the official names of this protein?
Mastoparan-V1.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Mastoparan subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NDOR1_DEBHA
Sequence: MSGISELSGVTILYGSETGNAQDYALFLAKRLKYFGLKPSVVSLDHYPLKNLVTDTKYLIVICSTTGQGELPRNSKKFMKFILKKKLPTDLLNHIELTTFGIGDSSYPKFNYAIKKIHARLLQLGCSELCTRCEADEQTPEGVDGYYSEWETNLLEALKSKIHGIPLTYDETVLLPADNPVEVSSNESDVPTSNSPTELSLTRMGDGSTNLLLGSVKANKRITKEGHFQDVRHLIIEGENLSYIPGDTLALYPSNDNESVETLIQSQPHWIPIADKPLLIHGEIPFVEGGLIDKSKLTLRSLITHHLDIISIPRRSFFMTLAHFSDSTTEDGEREQEKLREFSKIEESEELYNYANRPRRSILETILEFQQNLTIPVEYILDLFPIIKPRLFSIASRPSPNSVELIVAVVVYKTILRRVRRGLCTKWIKSLQDNDRIVFSIHKSNLKFELPTTKYPPILMVSPGTGVAPMKSLIEHITSLGIQQHLYLFYGCRNKENDYLFGDLWASLKSQNKLSIYPCFSRDQDSKIKYVQHKIYEQHELVGDLILNQNAIVFICGSSGAMPREVRITLVEILMKFGKMKDTEADDYLMDMENGGRYLQETW
What is the function of this protein?
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery.  In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.  Positively controls H(2)O(2)-induced cell death.
What are the official names of this protein?
NADPH-dependent diflavin oxidoreductase 1, NADPH-dependent FMN and FAD-containing oxidoreductase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure.
Protein: G6PI_HAEIG
Sequence: MKNINPTHTQAWKSLEAHKAELSNTTIQDLFKQEKNRFDDYSLTFNNQILVDFSKNNINQTTLSHLRQLAQECALDSAKEAMFTGEKINRTENRAVLHTALRNRTNTPVLVDGKDVMPEVNAVLAKMKDFCQRIISGEWKGYTGKAITDVVNIGIGGSDLGPYTVTEALRPYKNHLNMHFVSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAQSARDWLLKAAKDESAVAKHFAALSTNAKDVEKFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFENFEALLNGAHEMDKHFRSTPIEQNIPTTLALVGLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKYVDRDGNVINNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLIPCDFIAPAQSHNPLADHHNKLLSNFFAQTEALAFGKTKEEVEAEFIKAGKSLDDVKNIVPFKVFTGNKPTNSILVQKITPFTLGALIAMYEHKIFVQGVIFNIFSFDQWGVELGKQLANRILPELTDSEKVASHDSSTNGLINQFKTWR
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OXYR_MOUSE
Sequence: MEGTPAANWSIELDLGSGVPPGAEGNLTAGPPRRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASVPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAAEGSDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSARYLKGSRPGETSISKKSNSSTFVLSRRSSSQRSCSQPSSA
What is the function of this protein?
Receptor for oxytocin.  The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Oxytocin receptor, OT-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLGA_THIDA
Sequence: MKVLFVASEAFPLVKTGGLGDVLHGLPQALHGLGVGVRLLLPGYRTLLRQLDQVRIVAWFDVRGAEGPVAARVLETRHPGFDFPLWIVDCPPLFDRPGNPYVDVTGYDWPDNAERFAVFARVAALLAQDAHEAGWLPDVVHTHDWQTGLVPAFLADLPARPRTVFTIHNLAYGGHFPHGDFLRLQLPAHWWSHEGVEFHGGFSMLKAGIVYADAVTTVSPTYAEEICTPAFGYGLDGLLRSRRHKLHGILNGIDSATWDPADDPHLRARYTAGRILPGKRRDKQALLERFLPAADEAALQAPLVGLVGRLVEQKGIDWVLAAMPLLLAETDARFVLLGSGQAAYEQRLTRLARQHPTRVFVEIGYDEALAHQIEAGADMFLMPSRFEPCGLNQMYSLRYGTLPIVFKTGGLADTIVDTNEASLADGSANGFVFDTPDVAHFVDAVRRALALYRQPSLWRRVQQTGMRLSFDWRESAGHYLALYAADSAGEPDV
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: YDQ4_SCHPO
Sequence: MGFFSSLGQINVWSLLRPIIESDLEVIVIALGGYVLAKKGFLPRDAQKVISSLNVYFFTPCLVFEKVGNGLNLKMLIDLSLLPVFYVIISAASILISFLLAKLFRLTPRQRNFATACITFQNSNSLPLALVSSLATTVKDLLWDKIPDDTPDKVASRGIMYLLIFSQLGQALRWSYGYRILLSPNQPEDPLPIGNRSWSHSDVNEEEIQNLLASSANVDGVQNSVQANEGSTVQTDSSAISKNDNVQVETSNEEVGGFGAASSKISKFIVLLLDFFSPPLYSLFIALFIAVVPPLQRFFFEEGSFVEGSITSGIRMAGQVAVPMILVVLGASLATDISKTEPTQEVRKNNDTRVIIVCLLGRMVVVPLALLPAFSLLSYFSEISTVDDPVFVVVIFLLVGSPTAIQLTQICQLNGVFERECAKVLWWSYAVFTPPNSLLLAFASLLVVKWTK
What are the official names of this protein?
Uncharacterized transporter C5D6.04.
What is the protein family that this protein belongs to?
Belongs to the auxin efflux carrier (TC 2.A.69) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DPO4_PSEAE
Sequence: MRKIIHIDCDCFYAALEMRDDPSLRGKALAVGGSPDKRGVVATCSYEARAYGVRSAMAMRTALKLCPDLLVVRPRFDVYRAVSKQIHAIFRDYTDLIEPLSLDEAYLDVSASPHFAGSATRIAQDIRRRVAEELHITVSAGVAPNKFLAKIASDWRKPDGLFVITPEQVDGFVAELPVAKLHGVGKVTAERLARMGIRTCADLRQGSKLSLVREFGSFGERLWGLAHGIDERPVEVDSRRQSVSVECTFDRDLPDLAACLEELPTLLEELDGRLQRLDGSYRPDKPFVKLKFHDFTQTTVEQSGAGRDLESYRQLLGQAFARGNRPVRLIGVGVRLLDLQGAHEQLRLF
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_RHOPA
Sequence: MRLSRFFLPILKENPKEAEIVSHRLMLRAGMLRQEAAGIYAWLPLGHRVLKKIEQIVREEQNRAGAIELLMPTLQLADLWRESGRYDAYGPEMLRIADRHKRELLYGPTNEEMITEIFRAYIKSYKSLPLNLYHIQWKFRDEQRPRFGVMRGREFLMKDAYSFDVDEAGARKSYNKMFVAYLRTFARMGLKAIPMRAETGPIGGDLSHEFIVLAETGESGVYIDRDVLNLPVPDENVDYDGDLTPIIKQWTSVYAATEDVHEPARYESEVPEANRLNTRGIEVGQIFYFGTKYSDSMKANVTGPDGTDAPIHGGSYGVGVSRLLGAIIEACHDDNGIIWPEAVAPFRVTILNLKQGDAATDAACDQLYRELSAKGVDVLYDDTDQRAGAKFATADLIGIPWQIHVGPRGLAEGKVELKRRSDGARENLALADVVARLT
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  Can inadvertently accommodate and process cysteine.  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_CHLTE
Sequence: MSTLFLNARLLNPAENLDTVGSIKIGDDGLIEAVATGGESIPAKAEDNVIDLAGKVLAPGLFDMHCHFREPGQEYKETLETGSAAAVAGGFTGVALMPNTRPVIDSPLGVAYIRHHSAGLPIDLEVIGAMTVESRGEALAPYGKYASYSVKAVSDDGTAIQSSQIMRLAIEYAANFDLLLIQHAEDKHLTAGGIMNDGAVSAMLGLKGIPEVAEPIMIARDLQLIAWLKKHKLNGAVAEPRYHVAHISTAESVALVRKAKAAGLKVTCEVTPHHFTLTEHDLSSSIEKGNFIMKPPLASVENRDALIEGLRDGTIDAIATDHAPHAKHEKECPPDQAAFGIIGLETSLGLTITELVDKGVITLSQAIELLSTNPRRIMGLETILFRAGRKANLTIIDPDCEWIVSESDFGSKSRNTPFMGRKLKGRALGIYHNSKLIMR
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: DTX3_ARATH
Sequence: MEEPFLLQDEHLVPCKDTWKSGQVTVELKKVSSLAAPMAAVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSGFSILFGLAGALETLCGQAYGAKQYEKIGTYTYSATASNIPICVLISVLWIYIEKLLISLGQDPDISRVAGSYALWLIPALFAHAFFIPLTRFLLAQGLVLPLLYCTLTTLLFHIPVCWAFVYAFGLGSNGAAMAISVSFWFYVVILSCYVRYSSSCDKTRVFVSSDFVSCIKQFFHFGVPSAAMVCLEWWLFELLILCSGLLPNPKLETSVLSICLTTASLHYVIPGGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESAFFSTLLFTCRNIIGYAFSNSKEVVDYVANLTPLLCLSFILDGFTAVLNGVARGSGWQHIGALNNVVAYYLVGAPVGVYLAFNRELNGKGLWCGVVVGSAVQAIILAFVTASINWKEQAEKARKRMVSSENRLA
What are the official names of this protein?
Protein DETOXIFICATION 3, AtDTX3, Multidrug and toxic compound extrusion protein 3, MATE protein 3.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ATR8_STAC4
Sequence: MAVEKVQAFEKVSIPTEKQPGSEDLGFDPAELQKKYEAERNLRIQNGGVSQYRSAWKSGFGYYLEDPNADANFSRDPISARYDVVIMGGGFSGLLVAARLVQQGITNFTILDKSADFGGTWYWSRYPGAQCDVDSTIYLPLLEEVGYIPKEKYSFGPEILEHAQRIAKHFGLYPKALFQTEVKTCHWSEEDSLWTVQTDRGDNLRAQFIVSAFGISHMPKLPGISGIENFQGKSFHASRWDYNYTGGDSTGNMTKLADKRVGIIGTGATAIQVVPKLAESAKELYVFQRTPSSVDVRNNRPTDAEWAKTLRPGWQQERIDNFYAITTGENVTEDLIDDGWTEIFRLVAAPFFASADIEQSLENRMEQVQIADFKKMESVRARVDSLVKDPATAASLKPWYNQFCKRPCFHDEYLQAFNHPNVTLVDTRGHGVDAVTTKGVLAQGKEYELDCLIYSTGYEWYTEWEQRTRSQVYGRNGLTITKKWSQGITTYHGWGVHGFPNFMVLSSAQVNNVPNYTHMVGYLSRHLAYIVRTCKDRGIKSVEPTATAESKWVQQVVEQGAARRDQMKLCTPGYLNHEGDITEKTDRLYSYNGSGDSKFQIILDKWRDDGKLVGLSIDCATEADL
What is the function of this protein?
Baeyer-Villiger monooxygenase; part of the core atranone cluster (CAC) which products are predicted to catalyze most or all steps of mycotoxin atranone synthesis, starting from geranylgeranyl pyrophosphate (GGPP) (PubMed:25015739).  The initial cyclization of GGPP to dolabellane is probably performed by the terpene cyclase ATR13 (PubMed:25015739).  The Baeyer-Villiger oxidation near the end of the atranone synthesis, which converts atranones D and E to atranones F and G is predicted to be catalyzed by the monooxygenase ATR8 (PubMed:25015739).  Of the CAC's other predicted gene products, the reducing PKS ATR6 might synthesize a polyketide chain (PubMed:25015739).  This polyketide is probably transferred onto the atranone backbone by the polyketide transferase ATR5 (By similarity).  Other predicted CAC products include 4 oxygenases (ATR2, ATR3, ATR4, and ATR14), 3 short-chain reductases (ATR7, ATR9, and ATR10), and a methyltransferase (ATR12) (PubMed:25015739).  These may all be involved in the various steps of atranone biosynthesis, although their specific roles must await experimental determination (PubMed:25015739).
What are the official names of this protein?
Baeyer-Villiger monooxygenase ATR8, Core atranone cluster (CAC) protein 8.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
Protein: PYRB_SYNAS
Sequence: MKWERKDILGMKDLSVEEIHMILDTAESFLEVSARDIKKVPTLRGKTIINFFVEASTRTRTSFEIAGKRLSADTINISASASSLVKGETLADTARNLEAMNPDVIVIRHSCAGAPHMLAGLVRQSIINAGDGAHEHPSQALLDMMTIRNRKGGLSGLNVTIVGDIAHSRVARSNIYGLNKMGVCVTVAGPATMIPRDIQQLGVKVCFSLEEAILDADVIMMLRIQTEREQQNIFPSLREYSTFYCLNRENIKKAKKDVLVMHPGPVNRGVEISPEIADGVHSVILEQVTNGVAVRMALLYLLTGASS
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RS7_ACHLI
Sequence: MPRKGHIVKRDVLPDPIYNSKLITRIVNTIMEDGKKGTAQGILYGALNRIKDQTGREAIDVFNEALNNISPILEVRARRIGGQNYQVPVEVRPERRQALALRWLVQYAKKRNEKTMEERLAKEILDASQGTGAAVKKREEVHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RL19_LISIN
Sequence: MNKLIDEITKSQLNPDVPSFRPGDTVRVHAKVVEGTRERIQLFEGVVIKRRGAGISETFTVRKISNGVGVERTFPVHTPRIAKLEVIRRGKVRRAKLYYLRNLRGKAARIKEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SKA2_MOUSE
Sequence: MEAEVDKLELMFQKADSDLDYLQYRLEYEVKTNHPHSAGEKNAVTVLKELSAIKSRYQALCARFKAVSVEQKETKSCICATLNKTMTMIQELQKQTNLELTLLTEEEKAATEPLKSHMPD
What is the function of this protein?
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint.  The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies.  The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner.  In the complex, it is required for SKA1 localization.  Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
What are the official names of this protein?
Spindle and kinetochore-associated protein 2, Protein FAM33A.
What is the protein family that this protein belongs to?
Belongs to the SKA2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore- associated proteins.
Protein: RK21_GRATL
Sequence: MLYAIIEADGKQMWIEPGKYYDVNYIPGEPGDYIQFNKVLVLRQENDIYVGKPCIQSIIIKAKILKHLKSKKITVFKIKPKKNSRKKQGHRQKLTRLLIEEFYNQI
What is the function of this protein?
This protein binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L21, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KTHY_RHOPT
Sequence: MVQKKPINRSLRGRFITFEGGEGAGKSTQIRLLAKRLEKARLRTLVTREPGGSPGAEAIRSALLAGIGKLIGGADAEALLFAAARDDHVRTLIEPALARGEWVLCDRFYDSTRAYQGKLGAVSLDLLNALQQVTIGDMKPDLTVILDIPVEIGLARAAVRRGSETPDRFESEAIDFHRGLREVFRQIAAQEPERCALIDANAEPEEVADRIWQAVRLRLLEPARAGAKSA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.