PharMolix/UniProtQA huggingface dataset:
Protein: NHAP2_PSEPW
Sequence: MDASTINSLFLIGALLVGASILVSSLSSRLGIPILVIILAVGMLAGVDGGGIIFNNYPTAYLVGNLALAVILLDGGLRTRVASFRVALWPALSLATVGVMITTALTGLVAAWLFDLSLIQGLLIGAIVGSTDAAAVFSLLGGKGLNERVTATLEIESGSNDPMAVFLTVTLIDMIASGQTGLHWSLLGHLLREFGIGGLLGLGGGWLMLQLVNRINLAGGLYPILVIAGGLAVFSLTNALHGSGFLAVYLCGLVLGNKPIRSRHGILHMLDGMAWLAQIGMFLVLGLLVTPHDLLPIALPALGLALWMILIARPLSVVAALLPFKAFHGREKAFISWVGLRGAVPIILAVFPLMAGLPDAQLFFNLAFFIVLVSLLVQGTSLPWMAKLLKVTVPPDPAPISRSALEVHITSEWELFVYRLGAEKWCIGAALRELKMPEGTRIAALFRGEQLLHPSGSTVLEVGDMLCVIGHEHNLPALGKLFSQAPQRGLDLRFFGDFVLEGDAELGAVAALYGLKLDGLDAKMPLAQFIRQKVGGAPVVGDQVEWHGTIWTVATMDGNKIQKVGVRFPEGTRPGPGLFL
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FGD_MYCTO
Sequence: MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVFLGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGASIYDVPDGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAADRSVDGIDKMIEIKISYDPDPELALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQIAKRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRRLG
What is the function of this protein?
Is essential for the bioreductive activation of the bicyclic 4-nitroimidazole prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria.  It does not interact directly with PA-824 but, rather, provides reduced F420 to the deazaflavin-dependent nitroreductase Ddn, which in turn activates PA-824.
What are the official names of this protein?
F420-dependent glucose-6-phosphate dehydrogenase, FGD, FGD1, G6PD.
What is the protein family that this protein belongs to?
Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.
Protein: Y1076_ALKOO
Sequence: MADFNQLFDQWANTYDNTVFSTDNEYTQVFERYETTLQSICDAIQDKKQGLTLEIGVGTGNLTKHLEQQGFQVIGIEPSKQMRRIAKDKLPHIEIVDGHFLSIPVAKTFDSIVTSYAFHHLNLEEKHQALTYLDSFLNQSGKIVIADTMFESEEYKRELLNKVEKDRAYNLLEDLKAEYYEYINDITDIFLNLGYSFTISKMNKYVWIICATKGGL
What is the function of this protein?
Could be a S-adenosyl-L-methionine-dependent methyltransferase.
What are the official names of this protein?
Uncharacterized methyltransferase Clos_1076.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. YrrT family.
Protein: TATA_NEIMA
Sequence: MGSFSLTHWIIVLIIVVLIFGTKKLRNVGKDLGGAVHDFKQGLNEGTDGKEAQKDDVIEHKKDEDKA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: SGPP2_MOUSE
Sequence: MAELLRSLRDSQLVARFQRRCGLFPAREASGEEHVVKNYFYYYLFRFSAALGQEVFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKRIIAEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTYPAWTLIDSLDSASPLFPVCVIVVPFLLCYNYPVSDYYSPTRADTTTIVAAGAGVTLGFWINHFFQLVSKPTPSLPVIQNIPPLTTDMLVLGLTKFMVGIMLILLVRQLVQKLSLQVLFSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLL
What is the function of this protein?
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates.  Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (Probable).  Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity).  May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling.  May play a role in pro-inflammatory signaling (By similarity).  Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (PubMed:27059959).
What are the official names of this protein?
Sphingosine-1-phosphate phosphatase 2, SPPase2, Spp2, Sphingosine-1-phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the type 2 lipid phosphate phosphatase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VE1_FPVL
Sequence: YDVESTDEDGWKKILVFLTFQHINFKEFISILCMWLKGRPKKSCITIAGVPDSGKSMFAYSLIKFLNGSVLSFANSKSHFWLQPLTECKAALIDDVTLPCWDYVDTFLRNALDGNAICIDCKHRAPVQTKCPPLLLTSNYDPRLHGVDSGGG
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: TCTP_HEVBR
Sequence: MLVYQDLLTGDELLSDSFPYKEIHNGILWEVEGKWVVQGAVDVDIGANPSAEGADEDEGVDDQAVKVVDIVDTFRLQEQPAFDKKQFVTYMKRFIKLLTPKLDEEKQESFKKNIEGATKFLLSKLSDLQFFVGESMHDDGSLVFAYYRGGATDPTFLYFAYALKEVKC
What is the function of this protein?
Involved in calcium binding and microtubule stabilization.
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTPA2_CANGA
Sequence: MIPSKRILTDKDVKIWEESETREDILSFIESLAKAVEGFENDQVSEPVSDSVQSTIAVLTEIDKLIKLHPVIQDKNTSRFGKVEFRDFYDDVCEKADDLLSSHFPALTSEQIEQLSIYLQESWGNKRRIDYGSGHELNFICFLYGLTHYKIFDLQRDARNLVLVLFIEYLKIMREIETLYWLEPAGSHGVWGLDDYHFLPFLFGAFQLAPHKHLKPKSIHNEELVEMFADKYLYFGCIAFINSVKTSTSLRWHSPMLDDISGVKKWSKVAEGMIKMYKAEVLGKLPIMQHFYFSEFLVCPEGISEPRTHIHNGDEDDDQCCQDGAAHNTWGDCCGIKIPSLYAANAMEKQSHKPIPFD
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase.  Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A activator 2, Peptidyl-prolyl cis-trans isomerase PTPA-2, PPIase PTPA-2, Rotamase PTPA-2, Phosphotyrosyl phosphatase activator 2.
What is the protein family that this protein belongs to?
Belongs to the PTPA-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUK_ENTFA
Sequence: METVLVINPGSTSTKLALFANHDCLAEETLRHSVQELAPFENVVSQTSFRKQMIAEFLETHNIIQLAAVVGRGGLLKPIPGGTYLVDQQMLEDLRTERFNTHASNLGAILANEFAEKYHVPAFIVDPVVVDELQPLARISGLKGIQRRSVGHALNQKAVARKIAEDLGKTYEQSNFIVVHLGGGISLGAHQKGRMVDVVNGLDGEGPYTPERSGALPLVEFAQWILEQELTISQVKKLIAGNSGLKSYLGETDLRHIQAQIAAGDQTANYYLKGMCYQIAKSIGEMAVVLEGTIDAIILTGGAAYSQTVVQEISQKVTWIAPIKVYPGEMEMAALYEGVNRVLTGEEQALNYSEAKIEQE
What are the official names of this protein?
Probable butyrate kinase, BK, Branched-chain carboxylic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMK_HAEDU
Sequence: MKILMLCREPRLYSCQRLKQACQDRNIQLDILDPNRMLIKLAVIDAQMQAQLYYQAGEIYDKCRAEPSLLAEYDAVLPRFGVSSTMMGCRVLDYFAAKKVVILNNSTAFRLARDKWSSLQVLAAQHIPIPTSSFAGALFSTAAHISQHRIPLVIKTCSGSQGVGVMLSESKVHSVSLLQTLQQAKVDNLLQDFVVEARGQDIRAFVIGDRVVAAIERNGLENDFRANIHQGGSASVIQLNTAEQQLAVLAAKTIGLDVAGVDLIRSNKGLLVLEVNACPGLDGIEKASKLDIAGLIIDYLLAMKK
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: NR2E3_BOVIN
Sequence: MSSNVAAAVPAAVSASRKESPGRWGLGEEPTGVGPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVRMDSVESETEPRLQPLATPPALAGPSSRGPTPVSAARALGPQALMPPGHHHFMASLITAETCTKLEPEDADENIDVTSNDPEFPSSPYSSSSPCALDSIHETSARLLFMAVKWAKNLPVFSNLPFRDQVILLEEAWSELFLLGAIQWSLPLDNCPLLALPEASAGGSSQGRLVLASAETRILQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQLVRFGKLLLLLPSLRFISSERVELLFFRKTIGNTPMEKLLCDMFKN
What is the function of this protein?
Orphan nuclear receptor of retinal photoreceptor cells.  Transcriptional factor that is an activator of rod development and repressor of cone development.  Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit.  Enhances rhodopsin expression.  Represses M- and S-cone opsin expression.
What are the official names of this protein?
Photoreceptor-specific nuclear receptor, Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL7A_THEVO
Sequence: MEKSYVKFETPEDVSQKALDLVESAFRSGKIKKGTNEVIKSIERGESKLVVIAEDVNPPEVVYYLPSLCEDKKVPYVYVKKKADLGSKVGIASAASVSIVDYGKNEELYKSIVSAVEQLKK
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_HELHP
Sequence: MAKVYATGKRKTAIAKVWLTSGSGKLNINGQSLNDWLGGHEAIKMKVMQPLILTKQEKSVDIHAVTLGGGYSAQAEALRHGISKALNAYDVAFRAMLKPKGLLTRDSRVVERKKYGKRKARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: TUSC_YERP3
Sequence: MARKRIAFIFTQGPHGSSAGREGLDALLATSALSEDIGVFFISDGVLQLLPQQQPEKILARNYIATFGVLPLYDVENCYLCERSLQQRGLSKMADWILDVTVLSPADLRRELGTYDVVLTF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_PROM3
Sequence: MARIAGVDIPRDKRVEVALTYIYGIGLTRAKTILTKSGVNPDIRVKDLEDGDVQKLRTALEAFTIEGDLRRQEGMALKRLQDIGCLRGRRHRMSLPVRGQRTRTNARTRRGARKTVAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: AVR2A_RAT
Sequence: MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHMMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSGGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCLGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
What is the function of this protein?
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.  Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.  Receptor for activin A, activin B and inhibin A.  Mediates induction of adipogenesis by GDF6.
What are the official names of this protein?
Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PT100_PIG
Sequence: MGVKLEVFRMTIYLTFPVAMFWIANQAEWFEDYVIQRKRELWPPEKEDQPQELEDFKERIRKQREERLLRAAQQSS
What is the function of this protein?
Plays a role in mitochondrial complex IV assembly.
What are the official names of this protein?
Protein PET100 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PET100 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Mitochondrion. Mitochondrion inner membrane.
Protein: NACHO_MOUSE
Sequence: MASPRTITIMALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKALPESAEEQPSLYEKAPQGKVKVS
What is the function of this protein?
Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:28445721, PubMed:32204458).  Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:28445721, PubMed:32204458).  Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (PubMed:32783947).  Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721).  Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity).
What are the official names of this protein?
Novel acetylcholine receptor chaperone, Peroxisomal membrane protein 52, PMP52, Transmembrane protein 35A.
What is the protein family that this protein belongs to?
Belongs to the DoxX family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum membrane; Multi- pass membrane protein. Note=Shedding may lead to a soluble peptide.
Protein: PRMA_PROMP
Sequence: MEIKNWYELTFEIETNLEEIIIWKLNELGISSYAFEILLNNKNNKKVIIWLPHLNWPESLRIKLVRNIKEVLDKNNYQTNCFEWNLIEQEDWISSWKKYWGPEIVGDNLLILPCWLELPEEYKNKKVIKIDPGAAFGTGSHPTTSLCLEELEKISLSSKKILDIGSGSGILSIAARSFGASKIYSIDNDYLAINSTESNFRLNFGNLDNLKTYLGSFDGLVSKYTLKNFDFILCNILAEVIKGIIPDIRNCLKIDGEVILSGILNSQKDEIIKLLKASNLRINDVSSKKDWVCITAQKIP
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_ALKMQ
Sequence: MELKNKKVLVIGLAVTGVPLVRVLKQQGAQIIVNDMKSEVDLAETIDAIGHEQIEYILGRHPEELTTLGELDLVVLSPGVPLDIPFIQQIKAQGIEIIGEVELAFRLSRGKIVAITGTNGKTTTTALTGEIFKGAGKNTYVVGNIGVPFIEKALDTTEEDVIVIEVSSFQLESIKEFHPKVGTLLNLTPDHLNRHKTIENYREAKLNLFMNQSLQDYAVLNYDDITSREAGKTLAAQKIYFSRKQILEEGVFVDNQLITIQTKEKRYDVIHIDEIKILGQHNLENALAATAMTFILGVSAEDIAKGLRNFPGVAHRLEFVEEIEGVKYINDSKGTNTDASIKAIEAAQAPIILLAGGQDKGGDFTDFVKAFDGKVKHLLVYGETSDNIYETALHNNFKVVSQVRDLEEAVIRAKGIAQAGDTILLSPACASWDMYPNFEARGQHFKKLVSSLRRS
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_ACAM1
Sequence: MGRAKKVVLAYSGGVDTSVCIPYLKHEWGVEEVITLAADLGQGDELEPIRKKALDAGAAQSLIADGTESFIADYAFPAIQANALYENRYPLSTALARPLIAKLLVEAAEIHGADAVAHGCTGKGNDQVRFDVSITALNPDIKVLAPAREWGMSREETIAYGEKYGVQSPVKKSSPYSIDRNLLGRSVEAGPLEDPWVEPLEEVYDLTKAIADTPDQPEYVDIDFAQGLPTQLNGQALSPVALVEQLNQIVGNHGVGRIDMVENRLVGIKSREIYEAPALLVLIQAHRELESLALTADVTHYKRGIEETYSQLVYNGLWFSPLKDALDAFIQQTQKQVTGTVRVKLFKGAATVVGRQSPHSLYTPDLATYGAEDAFDHKAAEGFIYVWGLPTRVWSQQQR
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUKB_ECOHS
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAIERQEENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADSAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQLVVAINGPLARNEAWDVARELLREGVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPVWLAAQNSLNQLSEQCGEEFTSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRERLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFGQVNSVRLNVNVRETHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFLNTEHVHVVGLRGFAPQLPETLPGTDEAPSQAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: I4E1B_HUMAN
Sequence: MLAVEVSEAEGGIREWEEEEKEEEAAERTPTGEKSPNSPRTLLSLRGKARTGGPMEVKLELHPLQNRWALWFFKNDRSRAWQDNLHLVTKVDTVEDFWALYSHIQLASKLSSGCDYALFKDGIQPMWEDSRNKRGGRWLVSLAKQQRHIELDRLWLETLLCLIGESFEEHSREVCGAVVNIRTKGDKIAVWTREAENQAGVLHVGRVYKERLGLSPKTIIGYQAHADTATKSNSLAKNKFVV
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.
What are the official names of this protein?
Eukaryotic translation initiation factor 4E type 1B.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
Protein: NANO1_XENTR
Sequence: MDGGLCFNSWSDYLGLSSLISRGLQPREGGESPRPRWKASSPTPAEPLPSKAAEAHGHKGCGFCRSNREAQSLYSSHRLRAPDGRVLCPVLRGYTCPLCGANGDWAHTMRYCPLRHFLRHPHSPRDGQ
What is the function of this protein?
Acts as a translational repressor.  Can mediate repression affecting different steps in the translation process: cap-driven, IRES-driven, polyadenylated RNAs or nonpolyadenylated RNAs.  Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival (By similarity).
What are the official names of this protein?
Nanos homolog 1, Xcat-2 protein.
What is the protein family that this protein belongs to?
Belongs to the nanos family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Note=During early cleavage and blastula stages found close to the cell periphery in a germ plasm-like pattern. From gastrula stage on, detected predominantly in a perinuclear region (By similarity).
Protein: ENV_RSFFV
Sequence: MEGPAFSKPLKDKINPWGPLIILGILIRAGVSVQHDSPHQVFNVTWRVTNLMTGQTANATSLLGTMTDAFPKLYFDLCDLIGDDWDETGLGCRTPGGRKRARTFDFYVCPGHTVPTGCGGPREGYCGKWGCETTGQAYWKPSSSWDLISLKRGNTPRNQGPCYDSSAVSSDIKGATPGGRCNPLVLEFTDAGKKASWDGPKVWGLRLYRSTGTDPVTRFSLTRQVLNIGPRVPIGPNPVITDQLPPSRPVQIMLPRPPQPPPPGAASIVPETAPPSQQPGTGDRLLNLVDGAYQALNLTNPDKTQDCWLCLVSGPPYYEGVAVLGTYYNHTSALKEECCFYADHTGLVRDSMAKLRERLTQRQKLFESSQGWFEELFNRSTWFTTLIFTIIGPLIILLLILLFWTLHS
What is the function of this protein?
Envelope-like membrane glycoprotein.
What are the official names of this protein?
Glycoprotein 55, gp55.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Virion membrane; Single-pass type I membrane protein. Note=The envelope-like membrane glycoprotein gp55 is defective in its transport to the cell surface and remains associated predominantly with the rough endoplasmic reticulum (RER) membrane. It is almost not incorporated into virions. Host cell surface expression appears to be a prerequisite for its leukemogenicity (By similarity).
Protein: CGEB_BACSU
Sequence: MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLMKIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAILTIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMKEAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRPYHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAAFYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS
What is the function of this protein?
May be involved in maturation of the outermost layer of the spore.
What are the official names of this protein?
Protein CgeB.
Protein: RFC_SHIDY
Sequence: MTYFTGFILILFAIIIKRLTPSQSKKNIVLIANAFWGILLVGYTFNEQYFVPLSATTLFFILAFLFFFSMTYILIARSGRVVFSFGTGFIESKYIYWFAGMINIISICFGIILLYNNHFSLKVMREGILDGSISGFGLGISLPLSFCCMYLARHENKKNYFYCFTLLSFLLAVLSTSKIFLILFLVYIVGINSYVSKKKLLIYGVFVFGLFALSSIILGKFSSDPEGKIISAIFDTLRVYLFSGLAAFNLYVEKNATLPENLLLYPFKEVWGTTKDIPKTDILPWINIGVWDTNVYTAFAPWYQSLGLYAAIIIGILLGFYYGIWFSFRQNLAVGFYQTFLCFPLLMLFFQEHYLLSWKMHFIYFLCAILLAMRKALEYE
What is the function of this protein?
May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS.
What are the official names of this protein?
O-antigen polymerase.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.