PharMolix/UniProtQA huggingface dataset:
Protein: HCST_MACMU
Sequence: MIHPGHILFLLLLPVAAAQTTPGSCSGCGSLSLPLLAGLVAADAVASPLIVGAVFLCARPRRSPAQGDGKVYINMPGRG
What is the function of this protein?
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation.  Functions as docking site for PI3-kinase PIK3R1 and GRB2.  Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways.  Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells.  In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors.  In T-cells, it provides primarily costimulation for TCR-induced signals.  KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity).
What are the official names of this protein?
Hematopoietic cell signal transducer, DNAX-activation protein 10, Membrane protein DAP10.
What is the protein family that this protein belongs to?
Belongs to the DAP10 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PG4J2_BISBO
Sequence: SKDNQKNYIPLIVPFAT
What are the official names of this protein?
Unknown placental glycoprotein 45J2.
Protein: TPIS_RHIME
Sequence: MTPDIRPLVAGNWKMNGTRASLDQIKAMAEGVKGDLSARVDALICPPATLLYVATALCDDSPLMIGAQDCHQKQSGAHTGEVSAEMVADCFGTHVIVGHSERRTDHGEGDALVRAKTEAAHGADLVAIVCVGETEEERKAGRTLDILKRQLSESLPDQATAENTVIAYEPVWAIGTGLTPTVSDVEEAHAFMRRELVSRFGAEGGKMRILYGGSVKPSNAKELMGVANVDGALIGGASLKADDFLAIYRAYEELTA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FKB59_DROME
Sequence: MPEGNKIDLSGDGGVLKEILKEGTGTETPHSGCTVSLHYTGRLVDGTEFDSSLSRNEPFEFSLGKGNVIKAFDMGVATMKLGERCFLTCAPNYAYGAAGSPPAIPPDATLIFELEMLGWKGEDLSPNQDGSIDRTILEASDKKRTPSDGAFVKAHISGSFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEKMNVGETSRIKIQAKYAFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNYFKKENWALAIKMYTKCKNILPTTVHTNEEVKKIKVATHSNIALCHQKSNDHFEAKQECNEVLALDKNNVKALYRRGQCNLTINELEDALEDFQKVIQLEPGNKAAANQVIICKQKLKESKNKEKKLYANMFTKLAANDKETEPPRETDVLSKCGEWSEEDAKREAELTLERDNIIMI
What is the function of this protein?
May have a role in phototransduction; inhibits or prevents Ca(2+) induced stimulation of the trpl ion channel.
What are the official names of this protein?
FK506-binding protein 59, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase, dFKBP59.
Protein: RDL3_ARATH
Sequence: MAISFRTLALLTLSVLLISISLGVVTATESQRNEGEVLTMYEQWLVENGKNYNGLGEKERRFKIFKDNLKRIEEHNSDPNRSYERGLNKFSDLTADEFQASYLGGKMEKKSLSDVAERYQYKEGDVLPDEVDWRERGAVVPRVKRQGECGSCWAFAATGAVEGINQITTGELVSLSEQELIDCDRGNDNFGCAGGGAVWAFEFIKENGGIVSDEVYGYTGEDTAACKAIEMKTTRVVTINGHEVVPVNDEMSLKKAVAYQPISVMISAANMSDYKSGVYKGACSNLWGDHNVLIVGYGTSSDEGDYWLIRNSWGPEWGEGGYLRLQRNFHEPTGKCAVAVAPVYPIKSNSSSHLLSPSVFKLVVLFVFQLISLALL
What is the function of this protein?
Probable thiol protease.
What are the official names of this protein?
Probable cysteine protease RDL3, Probable cysteine proteinase At3g43960, RD21A-like protease 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: Y2140_DICDI
Sequence: MDGVIESPSNNTIKISPSTSDSSTTTPIITTPPTQSTATVTTKAAATTTTTEASTTPPPPQPTPTPTQSTATVTKEVETTTETIPPIVTKGKIKKSKKSIKKPTIVKRPTTPIDYKQWHTEWPIHVYSHPINGRYLVATKDLDEQTVILRDLPYTWAVDHATCDSVCQHCFLEVPLNQQILPTDFYMCEGCQRVGYCSANCRCIDYSQHRFECQIFKELDTEEYSPFLMSEIKLLVRTLSRKWLEDSITQTAGIDINDETIKKQNTYNQYKNPQSLIPQDNGLRYNDYAELVSNVENYNESLKESLSYWICKYVVKLSAKLGKIEDEFDLLNILLRNRCNAFYIQGRPRDGSSGESRGCGVYVRNSFFNHSCDPNVNYWVVNNTLEVECTLLKNVKEGDELTISYIDTTSPLNKRREKLLEGYLFNCLCTKCVADESLPLDQTGTLEKDDDDNDDEKEKMDEDDDEKDDDINNKNDKKSKYKSDGSTDDEEDEDNNNNKNNNKNKNNNSNNQDHQNNDKSN
What is the function of this protein?
Probable methyltransferase.
What are the official names of this protein?
SET and MYND domain-containing protein DDB_G0292140.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Protein: TAL_ACISJ
Sequence: MNQLDALKQYTTVVADTGDFKQLAQFQPQDATTNPSLILKAVQKPEYAPLLKDCVTRWHGRAIDELMDRLIVRFGCEILSIIPGRVSTEVDARLSFDTAATVARAERIVELYQAEGLHIDRVLIKIAATWEGIQAARQLEQRGIHTNLTLLFSFAQAVACGQAKVQLISPFVGRIYDWYKKQAGANWDEAAMAGANDPGVQSVRAIYNHYKHFGIGTEVMGASFRNTGQIVALAGCDLLTIAPELLAQLAASNAPVARVLDPEAARRVALQPVQYDEAGFRYALNADAMATEKLAEGIRAFAADAAKLEQLMQAAA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_BRUAB
Sequence: MIETLLPASALAFPAIDPVIFRVGPLAVHWYGLGYVVGILFAWWYGKKLLRSHRLWANNQPPMAPEALDDFVIWAALGVVLGGRIGYVLFYNFSYYISNPLAIPALWDGGMSFHGGILGTTLAMILFARSRGILVWSMFDTIAAGVPIGLGVVRVANFINSELWGRVSDVPWAVYFPNGGPLPRHPSQLYEAFLEGLVLFFVLFVLVWGARKLKQPGFVAGAFVTGYGLSRIAVEFFREPDAQIGYLFGGWLTMGMVLSVPMVLLGLWAMWRANRAAARNA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RMND1_PONAB
Sequence: MPATLLRAVAGSHRVLSKAHQCRRIGHLMLKPLKEFENTTCSTLAIRQNLDLFLPDKTAGGLNKSQILEMNQKKSDTSMLSPLNAAHYQDEKAHLPTMKSFGTHRRVTHKPDLLDSKWFIKILKRHFSSVSTETLVPKQDFPQMKRPLKASRTRQPSGTNLPVVSVNEDLMHCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMEPTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF
What is the function of this protein?
Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.
What are the official names of this protein?
Required for meiotic nuclear division protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RMD1/sif2 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=May be localized in mitochondrial RNA granules.
Protein: PLSC_MYCPN
Sequence: MKKLTQAFLRFCLRFLQLLSLVLVLPVFVLMLISSLISAKNYESIPENYPPEIRFKKVYRLVSLFLYIKGVKVVIVNPENVPKKAVLVVANHKSNLDPLILIKAFGKTEGVPPLTFIAKIELQDTWLFKIMKLIDCVFIDRKNLRQMAASLEQQQQIIRQGTALCVFPEGTRVLSRQIGEFKSGALKVAYNAFVPIVPLTIVGSMGHMESKKRLQKAQVERDRGYKIQVIFNTPINPINFNQIDSQNVANNVWREISQTYAQYCQD
What is the function of this protein?
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
What are the official names of this protein?
Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase, 1-AGP acyltransferase, 1-AGPAT, Lysophosphatidic acid acyltransferase, LPAAT.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Protein: PEPT_VIBVY
Sequence: MKHLVQRFIRYVTFDTQSNPKKKCCPSTSGQMKFAEHLKQELLDLGLSQVELDEHGYLMAKLPSNVAYPVPAIGFIAHMDTAPDASGKNVKPQIIEDYHGGDIALGIGDEVLSPVQYPELHALHGHNLITTDGTTLLGADNKAGIAEILSAIEMLIENPSIPHGDICIGFTPDEEIGRGADLFNVERFGAEWAYTIDGGPQGELEYENFNASSADVIFHGVSVHPGTAKDKMVNAMTLASQFHCRMPADETPETTEGYQGFYHLKSAEMGVARSELGYILRDFERDGIARRKAFMQSLADDMNTQLKHGSVEIRFTDSYYNMKEKVEPFPHVIELAKQAMEVCDVEPIIKPIRGGTDGARLSFMGLPCPNIFTGGYNFHGIHEFASIEQMEKSVQVIVKIAELTAKKYA
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_CYTH3
Sequence: MTNKPSRYTITSALPYANGPVHIGHLAGVYVPADIYARFLRSKGENVLFIGGSDEHGVPITIRAKKEGVTPQQVVDKYHVQIKQSFEELGISFDIYSRTSSKIHAETSSEYFKKLYEDGKFIEQTSEQYYDPKAEQFLADRYIIGTCPKCGNENAYGDQCEKCGSTLSPSELINPRSTLSGEKPVMKSTKHWFLPLDQYEPWLKQWILEDHKNWKTNVYGQCKSWLDQGLQPRAVTRDLDWGVPVPVAGAEGKVLYVWFDAPIGYISAAKDYFKNSEIKAVHKNNTWEDFWKKDDTKLVHFIGKDNIVFHCIIFPAMLKAEGSYILPDNVPANEFMNLEGDKISTSRNWAVWLHEYLEEFKGKQDVLRYALCANAPETKDNDFTWRDFQARNNNELVAIYGNFVNRALVLTHKYYDSVIPALGKLEASDEGVIMMLKEFPAKIAASIEQYRFREALGFMMDLARLGNKYLADTEPWKIYKENPERVKTILHIGLQIAANLAIVSEPFIPFTSAKLFTMLNLKANTWNNAGTIDLLKAGDQLGTAELLFDKIEDATIEAQVKKLEDTKQANLLANAEVKPLKENVSFDDFAKMDIRVATIIAAEKVAKTKKLLKLTLKTGIDERTVVSGIAEHFEPEAIIGQQVSLLANLAPREIKGIVSQGMILMAEDADGSLKFVQPAAVVNAGSMIG
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETD_CYACA
Sequence: MTIIKKPDLNNALLRAKLAKGMGHSYYGEPAWPNDLLYTFPIVILGTITCCVGLAVLEPSSLGEPANPFATPLEILPEWYLYPTFNMLRIIPNKLFGVISISLVPVGLGIVPFVENINKFQNPFRRPIATSVFIFGTVTTVWLGIGATMSIDKALTLGIFF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: DOCK9_HUMAN
Sequence: MSQPPLLPASAETRKFTRALSKPGTAAELRQSVSEVVRGSVLLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSDWHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHEDDEQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLDFSSAEPEVKSFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSPALMNGSGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYVNSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPTQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGPEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLLIKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDESLALPAVNPLVTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTDSGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSLTFNHSYGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSACLRRSRGGVFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKYAYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSEIMHEQLG
What is the function of this protein?
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.  Overexpression induces filopodia formation.
What are the official names of this protein?
Dedicator of cytokinesis protein 9, Cdc42 guanine nucleotide exchange factor zizimin-1, Zizimin-1.
What is the protein family that this protein belongs to?
Belongs to the DOCK family.
What are the subcellular locations of this protein?
Endomembrane system. Note=Associated with membranes.
Protein: TYSY_VIBCH
Sequence: MRQYLDLCQRIVDQGVWVENERTGKRCLTVINADLTYDVGNNQFPLVTTRKSFWKAAVAELLGYIRGYDNAADFRQLGTKTWDANANLNQAWLNNPYRKGEDDMGRVYGVQGRAWAKPDGGHIDQLKKIVDDLSRGVDDRGEILNFYNPGEFHMGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLALMAQITGKKPGLAYHKIVNAHIYQDQLELMRDVQLKREPFPAPQFHINPKIKTLQDLETWVTLDDFDVTGYQFHDPIQYPFSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1A19_ARATH
Sequence: MKQLSRKVTSNAHGQDSSYFLGWEEYEKNPYDEIKNPNGIIQMGLAENQLCFDLIETWLAKNPDAAGLKKDGQSIFKELALFQDYHGLPEFKKALAEFMEEIRGNRVTFDPSKIVLAAGSTSANETLMFCLAEPGDAFLLPTPYYPGFDRDLKWRTGAEIVPIHCSSSNGFQITESALQQAYQQAQKLDLKVKGVLVTNPSNPLGTMLTRRELNLLVDFITSKNIHLISDEIYSGTVFGFEQFVSVMDVLKDKNLENSEVSKRVHIVYSLSKDLGLPGFRVGAIYSNDEMVVSAATKMSSFGLVSSQTQYLLSALLSDKKFTSTYLDENQKRLKIRQKKLVSGLEAAGITCLKSNAGLFCWVDMRHLLDTNTFEAELELWKKIVYDVKLNISPGSSCHCTEPGWFRVCFANMSEDTLDLAMKRLKEYVESTDSRRVISKSSHDRIKSLRKRTVSNWVFRVSWTDRVPDER
What is the function of this protein?
1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate synthase 9, ACC synthase 9, Ethylene-overproduction protein 3, S-adenosyl-L-methionine methylthioadenosine-lyase 9.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: LGT_STAHJ
Sequence: MLFNLNYIDPTAFSIGPLSIKWYGIIIAVGILIGYFIAQESLKYVGLHKDRLVDVIFYSAIFGFIAARIYFVIFQWPYYAQNPIEIPMIWHGGIAIHGGLLGGFITGIIVCKIKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRTFLENLHIPEFIIRNMYIEGVYYHPTFLYESIWDILGFIILITIRKHLRVGETFTLYLIWYSIGRFFVEGLRTDSLMLTSHIRVAQLVSVILIIIGLVILIYRRIKYQPSLYKEAGPLTWNSSKAKVKS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NADD_YERPP
Sequence: MPIKSSDHSLYALFGGTFDPIHYGHLKPVEALAQQVGLQHIILLPNHVPPHRPQPEANAQQRLKMVELAVAGNPLFSVDSRELLRDSPSFTIETLEALRKERGAEQPLAFIIGQDSLLSLHKWHRWQALLDVCHLLVCARPGYSQSLETPELQQWLESHKVMDPQALSQRPHGAIYLADTPLLDISATDIRRRRHNGESCDDLLPQAVQRYIELQGLYRG
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: NDK_PECCP
Sequence: MTIERTFSIVKPNAVAKNAIGSIYARFESAGFTLVAAKMLRLSREQAEGFYAEHKGKPFFDGLVEFMMSGPIMVQVLEGENAVQRNRDIMGATNPANALAGTLRADYADSFTANAVHGSDSIESAQREIAYFFSDDEICPRA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRPS_CHLAB
Sequence: MAGESTNSVGNDITSLIQPGLDQVIQDEGVQVTLINSILGWCRIHIINPVKSSKIVKSRAFQITMIVLGIILLIAGLALTFVLQGQLGNNAFLFLIPAVIGLVKLLATSVFMEKPCTPEKWRLCKRLLATTEDILDDGQINQSNTIFTMDSSESTNAAAS
What are the official names of this protein?
Sulfur-rich protein.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KU_BPMCO
Sequence: MRSVGNVDLTIGLVTVPVKMVGVSESHDRKASMYHPHEDGNFGKIKMPKLCEDCGEVVPTADIAKGFEEGGDIVILTADELASIAAATGAALEVPQFVKAEQINPMLFANENIYRLVPDPKRGRQAATTYLMVRHILVSQELVGVVQYTRWGRNRLGVLDVEPSDDGGVLVIRNMMWADELRSTEGIVPTNVTEDDIDPRLLPVMASVVESMTGDWDPTAYTDRYTEQLSEAITAKAQGDEIATVASESGKAIDDVSDLLAKLEASIQKKAPAKKATARRKKTA
What is the function of this protein?
Required for replication of viruses with short cos ends (4 bases).  Stimulates dsDNA end-joining by host LigD.  Binds dsDNA with either blunt, 5'- or 3-overhangs, protecting it from host exonuclease degradation.
What are the official names of this protein?
Protein Ku, Cd-Ku, Gp87.
Protein: LUXS_STAA9
Sequence: MTKMNVESFNLDHTKVVAPFIRLAGTMEGLNGDVIHKYDIRFKQPNKEHMDMPGLHSLEHLMAENIRNHSDKVVDLSPMGCQTGFYVSFINHDNYDDVLNIVEATLNDVLNATEVPACNEVQCGWAASHSLEGAKTIAQAFLDKRNEWHDVFGTGK
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: AROB_PSEA7
Sequence: MRTLNVDLGERSYPIYIGENLLGDAQWFAPHIVGRRVAVISNETVAPLYLETLLGALEGREVTRVVLPDGEAYKQWETLQSIFDALLQDRHDRKTTLIALGGGVIGDMAGFAAACYQRGVNFIQVPTTLLSQVDSSVGGKTGINHPLGKNMIGAFYQPQAVVIDTASLKTLPARELSAGLAEVIKYGFICDEPFITWLEEHMDALLALEPAAVTEAIERSCAAKARVVGADERESGVRATLNLGHTFGHAIETQQGYGVWLHGEAVGAGTVMALEMSHRLGWLSAAERDRGIRLLRRAGLPVVPPADMTAEDFMEHMAVDKKVLDGRLRLVLLQGLGNAVVTGDFPREILDATLRTDYRALADQLGDE
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPPD1_ASPFU
Sequence: MAPSAISTSPPPTDRVSSSLASYKGYDHVHWYVGNAKQAASYYITRMGFKRIAYRGLETGCRSVCSHVVRNGDITFILTSPLRSLDQVDRFPPEEQELLKEIHAHLEKHGDGVKDVAFEVDSVDSVFYAATNNGAKIVSQPRTLEDDNGQVRVATIQTYGETTHTLVERGSYHGAFLPGYRMETGVEDPISQLLPGVHLNRIDHCVGNQDWDEMDKVCEYYEKALGFHRFWSVDDKQICTEYSALKSIVMASPNEVVKMPINEPAKGKKQSQIEEYVDFYNGAGVQHIALLTDDIIRDITNLKARGVEFIKVPDTYYEDIKVRLKKAGLTLHEDFETIRSLDILIDFDEGGYLLQLFTKHLMDRPTVFIEIIQRHNFSGFGAGNFKSLFEAIEREQALRGNLV
What is the function of this protein?
4-hydroxyphenylpyruvate dioxygenase; part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin (PubMed:19028908, PubMed:22046314).  The 4-hydroxyphenylpyruvate dioxygenase hppD catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisic acid (HGA) (PubMed:19028908, PubMed:22046314).  The protein hmgX is crucial for this conversion and thus, probably functions as an accessory factor to mediate specific activity of hppD (PubMed:22046314).  The homogentisate 1,2-dioxygenase hmgA is then involved in the cleavage of the aromatic ring of HGA and its conversion to 4-maleylacetoacetate (PubMed:19028908, PubMed:19715768).  When hmgA activity is lowered by the cell wall integrity (CWI) signaling pathway, HGA accumulates and leads to the production of pyomelanin through benzoquinone acetic acid after oxidation and polymerization (PubMed:19715768).  On the opposite, in non-stress conditions, both hppD and hmgA activities are balanced and HGA is degraded into 4-maleylacetoacetate (PubMed:19715768).  4-maleylacetoacetate is further converted to 4-fumarylacetoacetate by the maleylacetoacetate isomerase maiA, which is degraded into fumarate and acetoacetate by the fumarylacetoacetase fahA (Probable).
What are the official names of this protein?
4-hydroxyphenylpyruvate dioxygenase, 4HPPD, HPD, HPPDase, L-tyrosine degradation gene cluster protein hppD, Pyomelanin biosynthesis cluster protein hppD.
What is the protein family that this protein belongs to?
Belongs to the 4HPPD family.
Protein: FBXL3_HUMAN
Sequence: MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW
What is the function of this protein?
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function.  Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346).  The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346).  Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).
What are the official names of this protein?
F-box/LRR-repeat protein 3, F-box and leucine-rich repeat protein 3A, F-box/LRR-repeat protein 3A.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly nuclear.