PharMolix/UniProtQA huggingface dataset:
Protein: YQGF_SALCH
Sequence: MSDTLLAFDFGTKSIGVAIGQRITGTARPLPAIKAQDGTPDWTLIERLLKEWQPDEIIVGLPLNMDGTEQPLTARARKFANRIHGRFGVTVTLHDERLSTVEARSGLFERGGYRALNKGKVDSASAVIILESYFEQGY
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_BUCAP
Sequence: MIKKNKKVIIAMSGGVDSSVSAWFLKNENYQVEGLFMKNWEEDDEKEYCNAAKDLSDAEEVCKKLNIHLHKVNFSKEYWEKVFENFLNEHKKGKTPNPDILCNKEIKFKIFFNYAIQELQSDYIATGHYAQIKKKNGKYFLLKAVDLNKDQSYFLYTLKGIQLKNILFPIGGLKKSQVRIIAKKIGLKVAEKKDSTGICFIGPKKINNFLNRYIKAEKGDIITTEGTIVGKHNGLFCYTLGQRKGLGIGGIKGNYNIPWYVIEKNIINNTLIIAQGSCNKRLMSIGLIAEKINWINDDKIIFPFSCQAKIRYRQIDIFCNIKYINDFLIKVLFDSPVSSVTPGQSIVFYSSKICLGGGVIQSRLPLL
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_METEP
Sequence: MSTDLRTHVLSEHHVSRETAASLDLYVAQLTRWQTVKNLVGPATLKEVWHRHIADALQLLTVAPEATRWLDLGSGAGIPGLILALAGKERPGFHVGLVESNARKCAFLSETARLTGAPVTVHNARIEAVIGTLTDTEIVCARALAPLSQLLAWTEPLLTSGTIGLFPKGRDAATELTEAEDEWTFTRDLIPSRTDSQARIVRVTSLSRVDP
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_STRP2
Sequence: MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIVISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGARVSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVSTPTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRNDYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F261_MOUSE
Sequence: MSREMGELTQTRLQKIWIPHSSSSSLLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYRNYEFFRPDNMEAQLIRKQCALAALKDVHKYLSREEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPDIIAENIKQVKLGSPDYIDCDQEKVLEDFLKRIECYEINYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHVQSRTAYYLMNIHVTPRSIYLCRHGESELNLRGRIGGDSGLSARGKQYAYALANFIRSQSISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCRVESIYLNVEAVNTHRDKPENVDITREPEEALDTVPAHY
What is the function of this protein?
Synthesis and degradation of fructose 2,6-bisphosphate.
What are the official names of this protein?
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, 6PF-2-K/Fru-2,6-P2ase 1, PFK/FBPase 1, 6PF-2-K/Fru-2,6-P2ase liver isozyme.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phosphoglycerate mutase family.
Protein: RP30_VAR67
Sequence: MENVYISSYSSNEQTSMAVAATNIRELLSQYVDDANLEDLIEWAMEKSSKYYIKNIGNTKSNIEETKFESKNNIGIEYSKDSRNKLSYRNKPFIATNLEYKTLCDMIKGTSGTEKEFLRYLLFGIKCIKKGVEYNIDKIKDVSYNDYFNVLNEKYNTPCPNCKSRNTTPMMIQTRAADEPPLVRHACRDCKQHFKPPKFRAFRNLNVTTQSIHKNKEITEILPDNNPSPPESPEPASPIDDGLIRVTFDRNDEPPEDDE
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG134, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 30 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 30 kDa subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle (By similarity).
Protein: PKP4_MOUSE
Sequence: MPAPEQGSLVEEGQPQTHQEAVSTGPGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCRLGAESPSIASTSSTEKSFPWRSTDVPNPGVSKPRVSDTIHPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEAGSFHNSQTVNKADSRQHPFTGSTSNHVVRTSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAYSSSTLPAQRAASPYSQRPASPTAVRRVGSVTSRQTSNPNGPVPQYQTTTRVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTVHDMDQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQELRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYRTGSVGIGNLQRTSSQRSTLTYQRNNYALNTAATYAEPYRPVQYRVQECSYNRLQHTGPADDGATRSPSIDSIQKDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSILSDETVAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIREPRSEYDRTQPPMQYYNSQGDTTHKGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYQDDSTRKTLDAYRLYLQSPRSYEDPYCDDRVHFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSWV
What is the function of this protein?
Plays a role as a regulator of Rho activity during cytokinesis.  May play a role in junctional plaques (By similarity).
What are the official names of this protein?
Plakophilin-4, Armadillo-related protein.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells (By similarity).
Protein: EXOC3_BOVIN
Sequence: MKETDREAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDAVVRHSQLAAAVENLKNIFSVPEIVRETQDLIEHGELLQAHRKLMDLECSRDGLMYEQYRMDSGNTRDMTLIHSYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFTILDRTVTTRIEGTQADTRESDRMWLVRHLEIIRKYVLDDLIVAKNLLAQCFPPHYEIFRSLLRTYHQALSARMQDLAAEDLEANEIVSLLTWVLNTYTSVEMMGNAELAPEVDVALLEPLLSADVVSALLDTYMSTLTSNIIAWLRKALETDKKDWMKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKVLVLCLQQMNSFLSRYKEEAQLYRDEHLRDRQHPHCYVQYMVAVVNNCQTFKESIVSLKRKYLKHEAEEGVSLSQPSMDGVLDAIAKEGCGSLLEEVFLDLEQHLNELMTKKWLLGSNAVDIICVTVEDYFNDFAKIKKPYRKRMIAEAHRRAVQEYLRAVMQKRISFRSAEERKDGAERMVREAEQLRFLFRKLASGFGEEMDSYCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLAMRGDASRDMKQTIIETLEQGPAQASPDYVPIFKDIVVPSLNVAKLLK
What is the function of this protein?
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
What are the official names of this protein?
Exocyst complex component 3, Exocyst complex component Sec6.
What is the protein family that this protein belongs to?
Belongs to the SEC6 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Cell projection, neuron projection. Midbody. Golgi apparatus. Note=Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (By similarity). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB-dependent (By similarity).
Protein: FAM3B_HUMAN
Sequence: MRPLAGGLLKVVFVVFASLCAWYSGYLLAELIPDAPLSSAAYSIRSIGERPVLKAPVPKRQKCDHWTPCPSDTYAYRLLSGGGRSKYAKICFEDNLLMGEQLGNVARGINIAIVNYVTGNVTATRCFDMYEGDNSGPMTKFIQSAAPKSLLFMVTYDDGSTRLNNDAKNAIEALGSKEIRNMKFRSSWVFIAAKGLELPSEIQREKINHSDAKNNRYSGWPAEIQIEGCIPKERS
What is the function of this protein?
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
What are the official names of this protein?
Protein FAM3B, Cytokine-like protein 2-21, Pancreatic-derived factor, PANDER.
What is the protein family that this protein belongs to?
Belongs to the FAM3 family.
What are the subcellular locations of this protein?
Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
Protein: HIS6_BACCZ
Sequence: MLAKRIIPCLDVKEGRVVKGVNFIGLQDVGDPVEIAALYNDAGADEIVFLDITATHEGRKTIIDVVEKTASKVFIPLTVGGGISSVKDMYNLLRAGADKVSINSAAVRNPKLIEEGAQHFGSQCIVVAIDARKVAEGKWNVYVNGGRVDTGMDAIEWAKCVVMLGAGEILLTSMDADGTKNGYDLRLTEEISKSVSVPVIASGGCGHADHIIEVFQKTTVDAALAASIFHYGEATIGGVKRKLRNANVEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNC_OLEA2
Sequence: MHNTTRPAARLPVPAIRAHQLNKIYPNGTRAVSDVSLTVHTNEFVSVIGSSGAGKSSLLRCINRLIRPTSGTLELFGEDITKISGRHIRQVRGKVGMIFQQFNLVRRLSVLENVLVSRLRFNSSFIGHCCTLVRHFSRNEKEFAFECLQQVGIEHLAFQRADTLSGGQQQRVAIARALAQEPEIFLADEPIASLDPHSAEVVMDTLMQIHETRHIPVLVNLHHIDFATRYGKRIVGMRKGKIIHDVPPSCLTDDLITDIYGARINEAFGELAACA
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ABCA7_DICDI
Sequence: MKYNANTSNQFRAMFFKNATFLKRQKCSLGVQIAIPMALVIVLVILKLWIESQIENNSGPVGDSSGDDIMGSYISYKFDYMQGWFYTINPNNITNIGYKDGYGNGTGLLGGINQYEIYWNGSDLWVPYTVAVESGQKMNDMVLAQKQQLGQSSMGPLTFPIAGIQFNEFNPQNNLIDLTITCEQQIRYAYNNFENNLIYVLSQIQTSFINYLLNGNGVVVKTQISTLPYIYKSQQFDIASLLGGSFFPFALSFVLPLFMYSIVYEKQEKLRDLSLMMGLKMRNYWIMTFIFNFLTYVVIVSVISLICSAAKVSLFVKGSPFALFLLLFLWGLSMVSFAFFLSTFFKRTRAASIFGYFFVMVMVNLNSTLSLFNTSVPVFYYWVPILAFSRGISTLCGLCGNGLCPPLSQYTWDFELSRILFWLFIDTIVYLTLAVYLDKVLPREFGVPSHPLFFIKDLKELFSKKGKYRKLRDGDGINEKTKLINEYTIDGINNDDDDDGLMDEDVKKERDMIVKGEYNPEEMTLIVQGLRKQFPGRPKPALSNLYLSVKKGEVLGYLGPNGAGKTTSISILTGLYTPTSGTAHIAGLDIRYDMDKIHQVIGVVMQFDVLWEDLTCEETILYYTRLKGTPKSIEFESTHNILKEVNLLDVKDRFVKELSGGMKRRLSFAIAMTGESSIIFLDEPTTGLSIETRKDLWGTINELKKNRSIILTTHSMQEADILSDRIAIVSQGKLQCIGTQTHLKQKFGDGYSVRIDIQEDYQNTHNPTDLIKSFSPSATLSETFNGSYVYRLPKDSIISDLYEYLVLNKEQYHLQEWSLSQTSLEDVFLKISANDDTVN
What are the official names of this protein?
ABC transporter A family member 7, ABC transporter ABCA.7.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCA family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL6_PARL1
Sequence: MSRIGKYPVEVPKGVTVTLNGQDLAVKGPKGELKLTLVDDVTVEQGESGLKVAPREDTQRARAMWGLSRTLVKNIVTGVTDGFTKTLEINGVGYRAAIQGKNLQLNLGFSHDVLYPIPEGIDIKCTKPTEIVITGIDKQKVGQVAAEIRGYRGPEPYKGKGVKYAGEYIFRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ISPF_HAEIN
Sequence: MIRIGHGFDVHAFGEDRPLIIGGVEVPYHTGFIAHSDGDVALHALTDAILGAAALGDIGKLFPDTDMQYKNADSRGLLREAFRQVQEKGYKIGNVDITIIAQAPKMRPHIDAMRAKIAEDLQCDIEQVNVKATTTEKLGFTGRQEGIACEAVALLIRQ
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: BAHD1_HUMAN
Sequence: MTHTRRKSLPMLSSGLTGRREPLQMEDSNMEQGVEGVEPGMPESPGHLTGRRKNYPLRKRPLVPEKPKACKVLLTRLENVAGPRSADEADELPPDLPKPPSPAPSSEDPGLAQPRKRRLASLNAEALNNLLLEREDTSSLAGTRRSRAGDPHRSRDRDRATGGWSSSKKRPRLGDLGGGSRDLSPEPAPDEGPRRDGDPAPKRLASLNAAAFLKLSQERELPLRLPRAHAEVDGRSTEPPAPKAPRPKWPKVNGKNYPKAWQGASSGEAAGPPGWQGCPDEPWPSATPCGPSVQPSHQPLSKALESPLGLRPHLPLLMGGQAALKPEPGRPGEESPAPKQELHQPSFPTPQLSPLPMPGNPADYNGLCVGPELTALGSFYLYCGQEGLQCGGYSPCPMLPEGKLSPVAAPHEEGLLLAPSSVPSGTPFQHPPWGSSRYCSSEDTGVNGYSICGVLPLSVTHAGTTCGGCPYKMPFAAEGCRSLGQLEFPLPEAGHPASPAHPLLGCPVPSVPPAAEPVPHLQTPTSEPQTVARACPQSAKPPSGSKSGLRTGSSCRHTARSKAARRPSHPKQPRVQRPRPRRRRRRRTNGWVPVGAACEKAVYVLDEPEPAIRKSYQAVERHGETIRVRDTVLLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPEHLQGGRSPSMHEPLQNEVFASRHQDQNSVACIEEKCYVLTFAEYCRFCAMAKRRGEGLPSRKTALVPPSADYSTPPHRTVPEDTDPELVFLCRHVYDFRHGRILKNPQ
What is the function of this protein?
Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains.  May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1.  Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins.  At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.
What are the official names of this protein?
Bromo adjacent homology domain-containing 1 protein, BAH domain-containing protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3).
Protein: HISZ_VARPS
Sequence: MSAWVLPDHIADVLPSEARHIEELRRQLLDTARGYGYELVMPPLLEHLESLLSGTGEALDLQTFKLVDQLSGRSMGLRADTTPQVARIDAHLLNREGVARLCYCGPVLHTRPDRPHATREPLQFGAEIYGHAGLEADTEVLLLALDCLHASGLSDGVIVDLADARIVRALFAGVPVDAAVLARVHAALVAKDASELHALTRSFPAASRDGLRALVQLYGDASVLDEAAKALKGTPAVSAALAGLKQLAASLGADPARQISFDLADLRGYAYYSGMRFGIYVPGAADALVRGGRYDEVGAVFGRNRPAVGFSLDVRELVGVLPARPLRAAIRAPWSDAAGLREAIAGLRKAGEIVVCVLPGHGSEIDEFHCDRELVEHAGQWQVRAL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTXB_HETP5
Sequence: MTDLHKEWEKVQEMAFASWVNSVLEKRGGVEKISDVSTDLSDGVKLIFFLESVSGKKFPKKFDLEPKTRILRIQNLHLAMLFVDEDLKVKVQGVAAEEFVDNNKKMILGFLWTLYRKYRISVINEGDKSSEEGLLAWVKKTTDGYSGVNITNFKASFRDGNAYLALAHKFDPSVFKYDEFSGKDQIERLNAAFDFAEKGLGIPKLLDAESLSKGNVDERSIILYTSLFFHAYRAKEEREALEASQNSLANKLASLEQSLEGEKTSQDELARQKKELEESLRLIRQQNEQRNQRIADIQSKIDDALRGIDDEKMAKLDLESRLSKTEKDKAILELKLAETLDENERLRNKIEEDKKRAAAEAEGLGLLRTHIGHQITDIAKWQSFLDNPEAVPYTKTPVNLEAELASLQFEEQAKRLGSKVENENISLEKYLSLKEEELKSAGAPKKRTK
What is the function of this protein?
Actin-bundling protein.  When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks.  Plays a major role in cytokinesis (By similarity).
What are the official names of this protein?
Cortexillin-2, Cortexillin II.
What is the protein family that this protein belongs to?
Belongs to the cortexillin family.
Protein: GLGC_SYNY3
Sequence: MCCWQSRGLLVKRVLAIILGGGAGTRLYPLTKLRAKPAVPLAGKYRLIDIPVSNCINSEIVKIYVLTQFNSASLNRHISRAYNFSGFQEGFVEVLAAQQTKDNPDWFQGTADAVRQYLWLFREWDVDEYLILSGDHLYRMDYAQFVKRHRETNADITLSVVPVDDRKAPELGLMKIDAQGRITDFSEKPQGEALRAMQVDTSVLGLSAEKAKLNPYIASMGIYVFKKEVLHNLLEKYEGATDFGKEIIPDSASDHNLQAYLFDDYWEDIGTIEAFYEANLALTKQPSPDFSFYNEKAPIYTRGRYLPPTKMLNSTVTESMIGEGCMIKQCRIHHSVLGIRSRIESDCTIEDTLVMGNDFYESSSERDTLKARGEIAAGIGSGTTIRRAIIDKNARIGKNVMIVNKENVQEANREELGFYIRNGIVVVIKNVTIADGTVI
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: AGIT1_HUMAN
Sequence: MADTQCCPPPCEFISSAGTDLALGMGWDATLCLLPFTGFGKCAGIWNHMDEEPDNGDDRGSRRTTGQGRKWAAHGTMAAPRVHTDYHPGGGSACSSVKVRSHVGHTGVFFFVDQDPLAVSLTSQSLIPPLIKPGLLKAWGFLLLCAQPSANGHSLCCLLYTDLVSSHELSPFRALCLGPSDAPSACASCNCLASTYYL
What are the official names of this protein?
Putative uncharacterized protein encoded by AGPAT4-IT1, AGPAT4 intronic transcript 1.
Protein: RL22_DESOH
Sequence: MEQVSATARYLRIGPQKVRMLVDGIKGKSVEKGLNTLRFMPNKGAGLVEKALRSAVANAEEKNMDVDGLVILNVLVDQGPTLKRFRPRARGRATRILKRTSHITVVLAEKAAKN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL19E_METTH
Sequence: MNLTTQKRLAADILKVGVNRIWIDPERIDEVSRAITRDGVKQLIKDGAIKAKPKKGISSYRSKKIAQQKKKGRRRGPGSIKGAKGARRPKKDEWMTTIRALRKDLKEMRDNREINKSTYRKLYKMAKGGAFKSKSYMKTYARDHDMLR
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L19e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL19 family.
Protein: NUSB_BRUME
Sequence: MNSIPEGRPTPNLQRTANKRGVARLAAVQALFQMDVAGTGVMEVVAEYEAFRLGKEVDGTQYLDADPQWFRAIVAGVVEDQLKLDPMIHQALTEDWPLSRLDSTLRAILRAGAWELKARKDVPTAVIVSEYVDIAKAFYTEDEPKLVNAVLDRLALVIRGESRGAKPRHKS
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: METF_BUCBP
Sequence: MKLVYKNYHETLNQHLMNICEKVNISFEFFPPNNILSEKNLWQVIDKLKLLTPKFFSVTHGTNSKIRATCTSNIVKKIKKYTGIETVPHLTCINSTEEELKVIAKTYWDSGIRHILALRGDIFNTNCKPKIYAVDLIKLLKSIANFEISVAAYPEVHPEAVNAKYDIINLKRKVEAGATRAITQFFFNIDCFLRFRDLCVKNNITIDIVPGIFPISNFKQLLKFSSVSNVSIPKWLCCMFHGLDNDLNTSRIIGSSIAIDMVKVLYSEGIRSFHFYTLNKSEISFAICKILENKS
What is the function of this protein?
Catalyzes the NADH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.  Is required to provide the methyl group necessary for methionine synthetase to convert homocysteine to methionine; the methyl group is given by 5-methyltetrahydrofolate.
What are the official names of this protein?
5,10-methylenetetrahydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the methylenetetrahydrofolate reductase family.
Protein: RFC3_SCHPO
Sequence: MSIEKGKGRAMDIDLPLGSESTLPWVEKYRPANLEDVVSHKDIISTLEKFISSNRVPHMLFYGPPGTGKTSTILACARKIYGPNYRNQLMELNASDDRGIDAVREQIKNFASTRQIFASTFKMIILDEADAMTLAAQNALRRVIEKYTKNVRFCIICNYINKISPAIQSRCTRFRFQPLPPKEIEKTVDHVIQSEHCNIDPDAKMAVLRLSKGDMRKALNILQACHAAYDHIDVSAIYNCVGHPHPSDIDYFLKSIMNDEFVIAFNTISSIKQQKGLALQDILTCIFEALDELEIKPNAKIFILDQLATIEHRMSFGCSEKIQLSAMIASIKTGVDLAAKVN
What is the function of this protein?
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1.  Subunit 3 binds ATP.  Also involved in replication and DNA damage checkpoint controls, probably functioning as a checkpoint sensor.
What are the official names of this protein?
Replication factor C subunit 3, Replication factor C3.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMA_BART1
Sequence: MFLNSLDLPGQPEDSRIVVAMSGGVDSSVVAGLLKREGYNVIGITLQLYDHGAATHRVGACCAGQDIEDARRVAEMLGIPHYVLDYEKRFREAVIDPFAESYAHGETPVPCIACNQTVKFADLLATARELGADALATGHYIRSRSHGAHRALFRPLDNDRDQSYFLFATTQEQIDYLRFPLGDLPKARVREIAAEMGLVVANKHDSQDICFVPQGKYSDVIAKLRPEAANPGFIVHIDGKILGKHSGIVNYTVGQRRGIGVSTGEALYVVYLDVENARVIVGPREMLETHKLFLRDVNWLGDESLDNFPSQGIEVAVKVRSTRPPHLACLHYKEGVFSVDLLECENGVAPGQACVLYDGNGHEARILGGGFVTHSERAADIEVMLKRVLCNLETKDSVSSQLKTTAS
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.