PharMolix/UniProtQA huggingface dataset:
Protein: VSP01_TRIST
Sequence: MVLIRVLANLLILQLSYAQKSSELVVGGHPCNINEHRFLVLVYSDGIQCGGTLINKEWMLTAAHCDGKKMKLQFGLHSKNVPNKDKQTRVPKKKYFFPCSKNFTKWDKDIMLIRLNHPVNNSTHIAPLSLPSKPPSQDTVCNIMGWGTISPTKEIYPDVPHCANINIVDHAVCRAFYPGLLEKSKTLCAGILEGGKDTCQGDSGGPLICNGQIQGIVSVGGDPCAEPRVPALYTKVFDHLDWIKSIIAGNTAATCPL
What is the function of this protein?
Snake venom serine protease that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine protease KN1, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYH_CHRVO
Sequence: MAQKYQAVKGMNDVLPAESYQWEYFEEALRKLLADYGYQNIRTPIVEGTPLFVRSIGEVTDIVEKEMYTFVDSLNGDSLTLRPEGTAGTLRAVVEHNLLYNATPKLWYMGPMYRHERPQKGRYRQFHQVGVEALGLAGPDIDAEIIAMTADLWRRLGISQYVRLEINSLGNAEERAAHREALIAYLERHVDILDEDGKRRMHTNPLRVLDTKNPALQEMANAAPKLSDYLGEESRAHYEGWKAMIAALGIEYIENPRLVRGLDYYNRSVFEWVTSELGAQGTICAGGRYDGLIEQLGGKAASGIGFGMGMERVLLLLQDKGLLPAQRSVDVFLVNQGEGAGLYSMKLAQTLRAAGYSVVQHLGEASFKSQMKKADGSGAEFALIVGENEIQAGQVVVKALRADVAQQTVAADAVLATLATLKA
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CU19_ARADI
Sequence: ADMGMNIAGGAYNFGYNTGDAGGHSRVESGSGSSVAGSYSYVDANGDRRTVQYTAGPGGYQASGDVGVDRRTAAAAAALAAMAPKAPIPAPAAAPAAPWYNPVPVAPAIMAHPGGYIAKW
What is the function of this protein?
Component of the rigid cuticle of the spider.
What are the official names of this protein?
Adult-specific rigid cuticular protein 11.9, ACP 11.9.
Protein: SRY_PANTR
Sequence: MQSYASAMLSVFNSDDYSPAVQQNIPALRRSSSFLCTESYNSKYQRETGENSKDSVQDRVKRPMNAFFVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKANMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: YR604_MIMIV
Sequence: MSSLPRNAVARNSKMHKKRDSGVKLSRNINTLDAVCKKHAVGNLIFRNCKMASYEGRVSFVDHEETRGNMRSGVIVVKATSIYSSEDIYDVVKVREDKIARDLKKRQEDYEKTKLEVERLKRSEELANKLANNDPKHDQLVEKLNENNTVEPNNESTEESVEQITEQTVEQTTEQTVEESVEQTTEKTTQQTAEESVEQSTEQTVEKSGDQSTEKTTQQTAEESVEQSTEQPIEESNKNTNQNNDNKKKKKEKNKYYRNFMKDIKSKFSLKLRPENNYFEVKAETTDMIIEHSVVYEIVMVPPTKETYLLVIGDLQMKSSYLRQIDPQYKMDAVLKEQTEFMERIKAKEQLKIHQSPNNKLEPEDMILDDGTSTLTEIEYLGLEEES
What are the official names of this protein?
Uncharacterized protein R604.
Protein: PG077_MONPZ
Sequence: MAEFEDQLVFNSISARALKAYFTAKINEMVDELVTRKCPQKKKSQAKKPEVRIPVDLVKSSFVKKFGLCNYGGILISLINSLVENNFFTKNGKLDDTGKKELVLTDVEKRILNTIDKSSPLYIDISDVKVLAARLKRSATQFNFNGHTYHLENDKIEDLINQLVKDESIQLDEKSSIKDSMYVIPDELIDVLKTRLFRSPQVKDNIISRTRLYDYFTRVTKRDESSIYVILKDPRIASILSLETVKMGAFMYTKHSMLTNAISSRVDRYSKKFQESFYEDIAEFVKENERVNVSRVVECLTVPNITISSNTE
What is the function of this protein?
DNA-binding protein which binds to the hairpin form of the viral telomeric sequence.  Required for the production of mature virions (MV).
What are the official names of this protein?
Telomere-binding protein OPG077, 36 kDa late protein I1, Telomere-binding protein I1.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG077 family.
Protein: LDN2_ODOLI
Sequence: MFTLKKSLLLLFFLGTISLSLCQEERNADEEDGGEVTEEEVKRSFLDTLKNLAISAAKGAGQSVLSTLSCKLSKTC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Lividin-2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: OBG_RHOE4
Sequence: MSRFIDRVVLHVSAGKGGNGCASVHREKFKPLGGPDGANGGRGGDVILVVDENIHTLLDFHFHPNAKATNGKQGAGSNREGANGEDLILKVPDGTVVLDTDGNVLADLVGVGSRYDAAQGGRGGLGNAALASKARKAPGFALLGEDGVERDLVLELKSVADVGLLGFPSAGKSSLVSVLSAAKPKIADYPFTTLVPNLGVVSSGDTTFTVADVPGLIPGASEGRGLGLDFLRHIERCAVLAHVIDCATLDPGRDPISDIDALEAELAAYTPALSGDSGLGDLDKRPRVVILNKTDVPEAAELAEMVTPEIEARGWPVFTISAVSREGLRPLTFALAKMVRDYREAHPKPEPKRQVIRPVKVKDSSFTIEKDPDIPGGFVVRGTRPERWIRQTAFDNDEAVGYLADRLARLGVEDALVKKGAQPGASVTIGDVSFEWEPMTPAGIDLTRTGRGTDPRLDQVERIGADERKHARRVRRGLLDEDA
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_PORGI
Sequence: MKKDIIILGIESSCDDTSAAVVRNETMLSNVIAGQAVHKAYGGVVPELASRAHQQNIVPVVSEAIKRAGIRKEEIDAIAFTRGPGLLGSLLVGTSFAKGLSLSLGIPMLEVNHLHAHVLANFLREPGEESQHPSFPFLCLLVSGGNSQIILVRSPYDMEVIGQTIDDAAGEAFDKCAKVMGLGYPGGPIVNKLASEGNPDAFRFARPHVSGYDYSFSGLKTSFLYTLRDKLAEDPDFIEKNKADLCASLQHTVIDILMKKLRQAAKDHSIKQVALAGGVSANTGLRDAFHDHARRYGWTVFIPKFAYTTDNAAMVAISGYYKYLQGDFCPIDAVPFSRITV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPOA_VIBVY
Sequence: MMNPKRLSVPRLLTPVALAITLAACSSGPKTPTSVDITLEPTLSVQNYMINADSSEGSLQADWLIMAAKAALQNGDLAQADLLIKRLARMPLSEVQQAEWQLTRAAYHLKLNQADNVIELLNFKAWWKLPNEQWKDYYTLRVEAYTALQQPFEANRQLVTLSQYVDESQQAEIAQQIWANFTGYSQYEITQLHPDASEEVLDGWLQLAIYMKTMSANVPQLKNTLEHWFAENTAHPAALYTPAEIQSILDLEIVQPVHTALLLPLSGKYAKQAQLIRDGFIFAMMNDKDRDPEATLKVIDTNLYQPHQLKQQLTDEQIDFIVGPLRKDVIEVLQGELSDDSGQVSIPSLALNIPDELQTGTGICYLTLSPEQEVAQAAKHLFANGYKYPLIFAPQGNLGQRVVSAFEAEWKKYSTNKVAVSYFGDKRQLQRDVNSVFGLQESQQRIAQMEGLMKLPMETQPRSRRDIDSVYIAARSSELTLIKPFIEVAVNPDAKPPKLFSNSMSNSGEKQYEDLTGIVYSDIPMLLEVNPALDSQMEQLWPDQSNFQKRLQALGMDAYKLMAELPQMKVVPNHAVNGQTGVLTIDDQCVVHREISWKEHGAL
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
What are the official names of this protein?
Penicillin-binding protein activator LpoA, PBP activator LpoA.
What is the protein family that this protein belongs to?
Belongs to the LpoA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: FUT5_PONPY
Sequence: MDPLGPAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRPGLMAVEPVTGAPNGSRCQDSTATPAHPTLLILLWTWPFTTPIALPRCSEMVPGVADCNITADSSVYPQADAVIVHHWDIMYNPGANLPPPTRPQGQRWIWFSLESPSYCRHLEALDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSVHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFT
What is the function of this protein?
Catalyzes preferentially the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosaccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage and participates in the surface expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.  Preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate.  Also catalyzes to a lesser extend the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosaccharide via an alpha (1,4) linkage.  Preferentially catalyzes sialylated type 2 oligosaccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosaccharide acceptors.  Lactose-based structures are also acceptor substrates.
What are the official names of this protein?
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5, Fucosyltransferase 5, Fucosyltransferase V, Fuc-TV, FucT-V, Galactoside 3-L-fucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 10 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Protein: DCD_NEIMB
Sequence: MSIKSDKWIRRMSEEFGMIDPFEPNQIKEADGKRIISYGTSSYGYDIRCANEFKIFTNINSTIVDPKNFDPKNFVTVEDDCCIIPPNSFALARTVEYFRIPRNVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYAGEGVAQVLFFESDEICETSYKDRNGKYMGQTGVTLPKA
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: TTGD_PSEPT
Sequence: MRLERALRARQLIPLAAIWLLVGCGKQETVESTAVPPEVGVYTVKAQALTLTTDLPGRTSAYRVSEVRPQASGILQKRMFVEGAEVKQGEQLYQIDPRTYEALLARAEASLLTAQNLARRYERLLDTNAISQQQYDDAMATWKQAQAEAQMARINMQYTKVLAPITGRIGRSAVTEGALVTNGQAQELATVTQLDPIYVDVNQPITRLLGLKRALESGRLQRVGDNQAQVSLTLDDGTPYPLKGVLKFSEVSVAPSTGSVTLRAEFPNPDHKLLPGMFVHALLNEGEQQAAILVPHQAVGRDARGVPTVWVVKPDNTVESREVQTLQTVGNAWLLGAGINDGERVITEGVQLARSGITVKPVAAKNVKLMSEFGSQVQAQAH
What is the function of this protein?
The periplasmic linker protein component of an inducible organic solvent efflux pump.  Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene.  Is not involved in antibiotic or AMP efflux.
What are the official names of this protein?
Toluene efflux pump periplasmic linker protein TtgD.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Lipid-anchor.
Protein: SRPRA_BOVIN
Sequence: MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNNKKNKGAKKEGSDGPLATSKAAPAEKSGLPVGPENGEELSKEEQIRRKREEFIQKHGRGMEKSSKSSKSDAPKEKGKKAPRVWALGGSANKEVLDYSTPTTNGAPEAAPPEDINLIRGTGPGRQLQDLDCSSSDDEGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLTREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRHQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA
What is the function of this protein?
Component of the SRP (signal recognition particle) receptor (By similarity).  Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).  Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (By similarity).  SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
What are the official names of this protein?
Signal recognition particle receptor subunit alpha, SR-alpha, Docking protein alpha, DP-alpha.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.
Protein: SFGH1_ECOLC
Sequence: MELIEKHASFGGWQNVYRHYSQSLKCEMNVGVYLPPKAANEKLPVLYWLSGLTCNEQNFITKSGMQRYAAEHNIIVVAPDTSPRGSHVADADRYDLGQGAGFYLNATQAPWNEHYKMYDYIRNELPDLVMHHFPATAKKSISGHSMGGLGALVLALRNPDEYVSVSAFSPIVSPSQVPWGQQAFAAYLAENKDAWLDYDPVSLISQGQRVAEIMVDQGLSDDFYAEQLRTPNLEKICQEMNIKTLIRYHEGYDHSYYFVSSFIGEHIAYHANKLNMR
What is the function of this protein?
Serine hydrolase involved in the detoxification of formaldehyde.  Hydrolyzes S-formylglutathione to glutathione and formate (By similarity).
What are the official names of this protein?
S-formylglutathione hydrolase FrmB, FGH.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.
Protein: Y2210_BURA4
Sequence: MAGHSKWANIKHKKAAADAKRGKIWTRLIKEIQVAARLGGGDANSNPRLRLAVDKAADANMPKDNVKRAIDRGVGGADGANYEEIRYEGYGISGAAIIVDTLTDNRTRTVAEVRHAFSKFGGNMGTDGSVAFMFDHVGQFLFAPGTSEDALMEAALEAGADDVSTNDDGSIEVLCDWQAFSAVKDALEAAGFKAELAEVTMKPQNEVEFTGDDAAKMQKLLDALENLDDVQEVYTNAVIVEE
What are the official names of this protein?
Probable transcriptional regulatory protein BamMC406_2210.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_ECOLI
Sequence: MFYPDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVGRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRSNLDRSPMYAGVIEGVGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIQGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEIGRELGLVDDERWARFNEKLENIERERQRLKSTWVTPSAEAAAEVNAHLTAPLSREASGEDLLRRPEMTYEKLTTLTPFAPALTDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_MYCBP
Sequence: MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKPQVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNAAADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLLPAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: PSB7_RAT
Sequence: MAAVSVFQAPVGGFSFDNCRRNAVLEADFAKKGFKLPKARKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPYSVPNKKGTRFGRYRCEKGTTAVLTEKVTPLELEVLEEIVQTMDTS
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).  Within the 20S core complex, PSMB7 displays a trypsin-like activity.
What are the official names of this protein?
Proteasome subunit beta type-7, Macropain chain Z, Multicatalytic endopeptidase complex chain Z, Proteasome subunit Z.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: FKBP_CRYNH
Sequence: MGVTVENISAGDGKTFPQPGDNVTIHYVGTLLDGSKFDSSRDRGTPFVCRIGQGQVIRGWDEGVPQLSVGQKANLICTPDYAYGARGFPPVIPPNSTLKFEVELLKVN
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
FK506-binding protein 1, FKBP, Peptidyl-prolyl cis-trans isomerase, PPIase, Rapamycin-binding protein.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FCTA_BRADU
Sequence: MTKALTGVRILDFTHVQSGPTCTQLLAWFGADVIKVERPGVGDITRGQLQDIPNVDSLYFTMLNHNKRSITLDTKNPKGKEVLTELIKKCDVLVENFGPGVLDRMGFPWEKIQQINPKMIVASIKGFGPGPYEDCKVYENVAQCTGGAASTTGFRDGLPLVTGAQIGDSGTGLHLALGIVTALYQRTHSGKGQRVTAAMQDGVLNLARVKLRDQQRLAHGPLREYSQFGEGIPFGDAVPRAGNDSGGGQPGRILKCKGWETDPNAYIYFITQAPVWEKICDVIGEPTWKTDPNYAKPAARLPRLNEIFARIEQWTMTKTKFEAMEILNKDDIPCGPILSMKEIAEDQSLRATGTVVEVDHPTRGKYISVGNPIKLSDSPSDVQRSPLLGEHTDEILRSVLGFSDHQVADIHKSGALAPPQKQAAE
What is the function of this protein?
Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR).  Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate (By similarity).
What are the official names of this protein?
Formyl-CoA:oxalate CoA-transferase, FCOCT, Formyl-coenzyme A transferase, Formyl-CoA transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. Frc subfamily.
Protein: KRIT1_BOVIN
Sequence: MGNPENIEDAYVAVIRPKNAASLNSREYRAKSYEILLHEVPIEGQKKKRKKVLLETKLQGNSEITQGISDYVVETTEPISPANQGIRGKRVVLMKTFPLEGEKVGREAALFIVPSVVKDNTKYTYTPGCPIFYCLQDIMRVCSESSTHFATLTARMLIALDKWLDERHTQSHFIPALFRPSPLERIKTNVINPAYATESGQAENSLHMGYSALEIKSKMLALEKADTCIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDYSKIQIPKQEQWQRSRSSVTEDKERQWVDDFPLHRSACEGDSELLNRLLNERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPEIDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTVQQIMEGMRLSQETQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEILAELTNLDPQRETPQLFLRRDVRLPLEVEKKIEDPLAILILFDEARYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKSIVPITKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQRMFLQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLKYGCFMWQLGDADSCFQIHSMENKMSFIVHTKQAGLVVKLLVKLNGQLMPMERNS
What is the function of this protein?
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity.  Negative regulator of angiogenesis.  Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells.  Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade.  Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B.  Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization.  Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1.  Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage.  Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2.  Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.  Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner (By similarity).  May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (By similarity).
What are the official names of this protein?
Krev interaction trapped protein 1, Krev interaction trapped 1, Cerebral cavernous malformations 1 protein homolog.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell junction. Note=KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. Association with RAP1 relocalizes KRIT1 from microtubules to cell junction membranes. Translocates from the cytoplasm along microtubules to the cell membrane in an ITGB1BP1-dependent manner (By similarity).
Protein: MNMG_ECOL6
Sequence: MFYPDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVGRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRSNLDRSPMYAGVIEGVGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIQGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEIGRELGLVDDERWARFNEKLENIERERQRLKSTWVTPSAEAAAEVNAHLTAPLSREASGEDLLRRPEMTYEKLTTLTPFAPALTDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSG_MYCTU
Sequence: MTTFDGDTSAGEAVDLTEANAFQDAAAPAEEVDPAAALKAELRSKPGDWYVVHSYAGYENKVKANLETRVQNLDVGDYIFQVEVPTEEVTEIKNGQRKQVNRKVLPGYILVRMDLTDDSWAAVRNTPGVTGFVGATSRPSALALDDVVKFLLPRGSTRKAAKGAASTAAAAEAGGLERPVVEVDYEVGESVTVMDGPFATLPATISEVNAEQQKLKVLVSIFGRETPVELTFGQVSKI
What is the function of this protein?
Participates in transcription elongation, termination and antitermination.
What are the official names of this protein?
Transcription termination/antitermination protein NusG.
What is the protein family that this protein belongs to?
Belongs to the NusG family.