PharMolix/UniProtQA huggingface dataset:
Protein: C3H2_ARATH
Sequence: MDVVCTEHQMRKPTVEIPPRKLLLSSKSFPSDSSSPRSPRKHNWNKSNKITSEHEEDNEDNNRENKEYCYDSDSDDPYASDHFRMFEFKIRRCTRSRSHDWTDCPFAHPGEKARRRDPRRFQYSGEVCPEFRRGGDCSRGDDCEFAHGVFECWLHPIRYRTEACKDGKHCKRKVCFFAHSPRQLRVLPPENVSGVSASPSPAAKNPCCLFCSSSPTSTLLGNLSHLSRSPSLSPPMSPANKAAAFSRLRNRAASAVSAAAAAGSMNYKDVLSELVNSLDSMSLAEALQASSSSPVTTPVSAAAAAFASSCGLSNQRLHLQQQQPSSPLQFALSPSTPSYLTNSPQANFFSDDFTPRRRQMNDFTAMTAVRENTNIEDGSCGDPDLGWVNDLLT
What is the function of this protein?
Probable transcription repressor that functions as negative regulator of phytochrome-mediated promotion of seed germination.  Inhibits seed germination by regulating the expression of gibberellic acid (GA) and abscisic acid (ABA) metabolic genes.  Does not regulate the expression of the DELLA genes RGA and RGA1.  Activated by PIL5, a phytochrome-interacting basic helix-loop-helix transcription factor (PubMed:18487351).  Represses directly JMJ20 and JMJ22 expression in the absence of red light (R) and in far-red (FR) conditions (PubMed:22483719).
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 2, AtC3H2, Protein SOMNUS, SOM, Tandem CCCH Zinc Finger protein 4, AtTZF4.
What are the subcellular locations of this protein?
Nucleus.
Protein: GYRB_STAAM
Sequence: MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANKIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OGFD1_MOUSE
Sequence: MNGKRPADPGPARPMKKGKKQVSAEFSDAVTEEILRKQVAEAWSCRTPFSHEAIALDMDPFLHCVIPNFIQSQDFLEGLHKELLSLDFHEKYNDLYKFQQSDDLKNRKEPHISALRKLMFEDFRAWLSKVSGIDLEPTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPSWDRDLGGTLDLYDTDEHLQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEETSRLSISGWFYGPSLTRPPTYFEPPIPRNPHIPQDHEILYEWINPAYLEMDYQMQIQEEFEERSEILLKEFLKPEKFAEVCEALEKGDVEWKSHGPPNKRFYEKAEENNLPDVLKECMGLFRSEALFLLLSNLTGLKLHFLAPSEDDETEEKGEGETASAAAGTEEGTSRRPSGPENNQVAAGSHSQENGEQADPEAQEEEAKKESSVPMCQGELRRWKTGHYTLVHDNTKTEFALDLFLYCGCEGWEPEYGGFTSYIAKGEDEELLIVNPENNSLALVYRDRETLRFVKHINHRSLEQSKAFPSRSGFWDFAFIYYE
What is the function of this protein?
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency.  Involved in stress granule formation.
What are the official names of this protein?
Prolyl 3-hydroxylase OGFOD1, 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, uS12 prolyl 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the TPA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MAZF_STAEQ
Sequence: MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRTLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis.  It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA.  Neutralized by coexpression with cognate antitoxin MazE.
What are the official names of this protein?
Endoribonuclease MazF, Toxin MazF, mRNA interferase MazF.
What is the protein family that this protein belongs to?
Belongs to the PemK/MazF family.
Protein: RRF_SHEAM
Sequence: MIEDIKKDAQDRMGKCVEATKAQMAKVRTGRAHPSLLDTIQVNYYGSMTPLKQVGNVTIEDSRTLAVNVFDRSAIQAVEKAIMSSDLGLNPMSAGATIRIPLPPLTEERRRDLVKVVRAEAEQGRVAIRNVRRDANSSFKQLEKEKECTEDDVRRSEEEVQKITDLHIKKIDELLAAKEAELMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRAD_ECOLI
Sequence: MMRQSLQAVLPEISGNKTSSLRKSVCSDLLTLFNSPHSALPSLLVSGMPEWQVHNPSDKHLQSWYCRQLRSALLFHEPRIAALQVNLKEAYCHTLAISLEIMLYHDDEPLTFDLVWDNGGWRSATLENVS
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraD.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family. IraD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2159_SHESA
Sequence: MTHDKTCPCGSPKIYQDCCQILHLGLDSGAQLATSPEQLMRSRYCAFVLKNFDYIIKTHHAAYLDGLTLEQLQQGPHPEWLGLDVLSANDTTQPDGSKFGTVTFKAWYKMSGEIDAIYERSEFIFEQGRWFYTKGHQMHAKLPGRNDPCVCHSGKKFKQCCMKG
What are the official names of this protein?
UPF0225 protein Shewana3_2159.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: TX337_LYCSI
Sequence: MKFVLLFGVFLLTLFSYSSSEMLDDFDQADEDELLSLIEKEEARAKECTPRFYDCSHDRHSCCRTELFKDVCTCFYPKRGDNEVCTCQPPKHLMYMEKAADKAKKFGGKIKKWFG
What are the official names of this protein?
U3-lycotoxin-Ls1s, Toxin-like structure LSTX-B37.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NUON_RHOCA
Sequence: MTKAEFSLVLPEVLLAIYAMGVLLFGVWTGKDRVAKPILWASAVTMLALALIIGLGTGNDTAFGGLFIADGFARFSKVVILVSAAAVLAMSSDYMGRRGLLRFEYPILIVLAVVGMMMMVSAGDLMSLYIGLELQSLALYVVAALRRDSAVSSEAGLKYFVLGSLSSGLLLYGASLVYGFAGTTTFSGIITVVEQGHLPIGLLFGLVFLLAGLAFKVSAVPFHMWTPDVYEGSPTPVTAFFATAPKLAAMALIARVVHDAFGQVPGEWGQILAALALASMYLGAIAGIGQRDIKRLMAYSSISHMGFGLLGLAAGTAAGVESMLLYMTIYIVMNVGTFAFILSMERDGKPVTEIAALNMLSKTDPVKAFALLVLLFSLAGVPPMLGFFAKFAVIKAAIGAGFVWVPVAAVVASVIGAFYYLRIVYFMYFGEKSAPLDGRMPALQFAFLVLAAVAMLGGAINMAGVEGAAQAAAASLVN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cellular chromatophore membrane; Multi-pass membrane protein.
Protein: RS21_PSE14
Sequence: MPAVKVKENEPFDVALRRFKRSCEKAGVLAEVRSREFYEKPTSERKRKAAAAVKRHAKKVQREQRRAVRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: AROK_NITEU
Sequence: MHFRYNYRMQRSKTPNTKNSDTGSIPGNIILIGMMGSGKTTVGKLLANLVGKTFIDIDHEIQRRTGVGIPVIFEIEGEAGFRKRESEVLRDIVRQQNIVLATGGGAILHPDNRALLRQHGTVVYLCAPVTELRRRTYLDKNRPLLQTGNVHAKLIELFTQRDPLYRETAHIIMDSGRQSARAFVQKLIQKLRQSNQEFTAAGSPPCVKPSE
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSA_RALSO
Sequence: MAGIESVLQETRVFEPPASFVKQANIAGMDAYRTLCAEAERDYEGFWARLAHEHLLWHKPFSKVLDESRAPFYTWFEDGELNASYNCLERNLENGNADKVAVIFEADDGSVARITYRELHARVCRFANGLKALGIRKGDRVVIYMPMSIEGVVAMQACARIGATHSVVFGGFSAKSLQERIVDVGAVAVITADEQMRGGKALPLKAIADEALAMEGSEAVRHVIVYRRTGAGVNWVEGRDRAMDEVEAGQPDTCEVTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWALLTMQWTFDLKPDDVFWCTADIGWVTGHTYIAYGPLAAGATQVVFEGVPTYPNAGRFWDMIQKHRVNTFYTAPTAIRSLIKAAEADETSHPKRYDLSSLRLLGTVGEPINPEAWMWYHTNIGGGRCPIVDTFWQTETGGHMISPLPGATPLVPGSCTLPLPGIMAAIVDETGQDLPDGQGGILVVKRPWPAMIRTIWGDPERFRKSYFPAELGGKLYLAGDGSVRDKETGYFTIMGRIDDVLNVSGHRMGTMEIESALVANPLVAEAAVVGRPDDMTGEAICAFVVLKRTRPNGDEARQIATDLRNWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEDITQDTSTLENPAILEQLKEAR
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: RHRA_RHIME
Sequence: METIRPLKFGTLSLPDRESRLVCRSILLDMLGEATIAPDEGDLTGVTGLFWKYVSLSLATVYFPRTMLRVNASGMGDSGVVILRAMDSPLVIRHRRIKVEAARADVIFLPSDASSEITLPEGGRFDCAHLPAYALASKRDLLKPIMMQPLAAECLPLQLLTNYAGYLLRQEYQSEEHAGMMVAHFYDLLPVLAQDIGNVSPRETPHNRMASIKMRVEQNLANGSFSITDVAEAERITPRAIQKFFSREGTTFSRYVLGRRLSLAKSLILAEGEATSISQIAYNVGFNDLSYFNRTFRSRYGVRPSDLRRLAAAA
What is the function of this protein?
Transcriptional activator of the rhizobactin regulon.
What are the official names of this protein?
Transcriptional activator RhrA.
Protein: PHOQ_SALCH
Sequence: MNKFARHFLPLSLRVRFLLATAGVVLVLSLAYGIVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKISVELPENLDMQSPTMTLIYDETGKLLWTQRNIPWLIKSIQPEWLKTNGFHEIETNVDATSTLLSEDHSAQEKLKEVREDDDDAEMTHSVAVNIYPATARMPQLTIVVVDTIPIELKRSYMVWSWFVYVLAANLLLVIPLLWIAAWWSLRPIEALAREVRELEDHHREMLNPETTRELTSLVRNLNQLLKSERERYNKYRTTLTDLTHSLKTPLAVLQSTLRSLRNEKMSVSKAEPVMLEQISRISQQIGYYLHRASMRGSGVLLSRELHPVAPLLDNLISALNKVYQRKGVNISMDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDDHLHIFVEDDGPGIPHSKRSLVFDRGQRADTLRPGQGVGLAVAREITEQYAGQIIASDSLLGGARMEVVFGRQHPTQKEE
What is the function of this protein?
Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides.  In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG).  In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PAG and may lead to expression of some PRG (By similarity).
What are the official names of this protein?
Virulence sensor histidine kinase PhoQ, Sensor histidine protein kinase/phosphatase PhoQ.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PROA_SALAI
Sequence: MSVVEQAQRARTAAAELAVATRSVKDAALHAMADALVARTPEILAANGADLAAGREGGLNAAVLDRLALDTGRVAGIADALRQMAALPDPIGEVVRGSTLPNGLELRQVRVPFGVVGIVYEARPNVTVDAAGICLKSGNAVLLRGSSSAAQSNAALVAVLRDAVAGAGLPADSVQLLDATTRDSVKELMRARGLVDVLIPRGGAALIRTVVEESTVPVIETGVGNCHVYVDAAADVSKAVAIALNAKTQRLSTCNTAESLLVHAAVADAFLPPALAALAAAGVTVHGCPEVARYSAAVLPATDEDYATEYLSADISVAVVDSLDAAVAHIRRYGTGHTEAIVTDSQPAAREFVARVDAAAVMVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLPELTSTKYVVTGDGQLR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPYC_HUMAN
Sequence: MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDKVEIEIATVMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVGSLV
What is the function of this protein?
May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.
What are the official names of this protein?
Epiphycan, Dermatan sulfate proteoglycan 3, Proteoglycan-Lb, PG-Lb, Small chondroitin/dermatan sulfate proteoglycan.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: RECO_ACTPJ
Sequence: MIENWHRGFVLHRREYSETSLLVDFFTEEHGRITLLAKGARRPHSPLKAVLQPFTPLLLRWSGKGDLKTLTKAEPASLTLPMQTLALYSGFYVNEVLARVLENQTAYPELFQHYLQCMTRLATQPEQIEPILRTFEFQMLKALGYGVNFSICAATGDPVSPSMTYQFRENQGFIASLLQNNYTFLGKDLLAFEQLDFSDKATLQAAKRFTRMALKPYLGSQPLKSRELFQNILPNKLKSG
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RL7_SHESH
Sequence: MSITKDDILNAVAEMSVMEVVALIEAMEEKFGVSAAAAVVAGGAEGGAAAAEQTEFDVMMTSFGENKVKVIKALRGATGLGLKEAKAMAESAPVAVKEAITKEEAEALKTDLEEAGASVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RLMF_SALEP
Sequence: MSAQKPGLHPRNRHQHRYDLAALCQTTPELTSFLIRTPAGEQSVDFANPQAVKALNKALLAHFYAVTHWDIPPGFLCPPVPGRADYIHHLADLLGETTGSIPAQATILDVGVGANCIYPLIGVHEYGWRFTGSEVSDAAMSSAQAIIQANTGLSRAIRLRRQKDPAAIFTGIIHKNEFYDATLCNPPFHDSAAAARAGSERKRRNLGQNKDDALNFGGQQQELWCEGGEVAFIKKMIAESQSFRRQVLWFTTLVSRGENLPPLYRALTEAGAVKVVKKEMAQGQKQSRFIAWTFMDDDQRRRFITRKR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_ERYLH
Sequence: MSGAAAHVPVLLDEVVAALDPQPGDVLVDATFGAGGYTRALLDSGATVHAFDRDPDAIAAGSQWPETKEEPPRLVLHPRRFSEMVHALAEAGVAQVDGVAMDIGVSSMQLDQAQRGFAFSADGPLDMRMSQHGPSAADFLNSAEAEEIADVLYQYGEERQSRRVARAIIAARPLETTGDLARVVRKALGYRVGAPKDPATRTFQAVRIHVNGELDELREGLHAAEHLLRSGGRLAVVSFHSLEDRIVKRFLQSASGKAGGTSRYLPQTDVSPAIFSDISKAIRPSEAEIARNPRARSSTLRHATRTDAPPRKEAA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIAA_ESCF3
Sequence: MQERIKACFTESIQTQIAAAEALPDAISRAAMTLVQSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDV
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: NUOG_RICFE
Sequence: MIKLNIDGSEIEVSEGSTVYQACTQAGKEIPHFCYHERLKIAGNCRMCLVEMEKSPKPIASCAMPVSNGMVIHTDTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAFRYGKGTNRFHENKRSIKDKYMGPLIKTAMTRCIQCTRCIRFANDIAGIEEMGAIHRGEHMEVTSYLEQTLDSEMSGNMIDICPVGALNSKPYAFKARKWELKHTASIGVHDAEGSNIRIDSRGDEVMRILPRVNEEINEEWLSDKNRFSYDGLKYQRLDLPYIRKNGKLVEASWSEALKTIADKIKSVKPEKIAAIAGSLVSVEAMFMLKTLLQKLGSNNYSVNQFDYKFDTTQRGNYLFNTTIAGVEKADLCLLIGANLRQIAPVLNSRIGQRVRAGSLKVARIGEGHNQTYRIQDLGSDIKIIEELAIGTHEFTKALKAAKYPMIIVGDGVYARDDGYAILSLIHKIVAEYNIMRDDFQGFNMLHNHASIVGGLDIGFNTPIKLEELELTYLLGADELPFDKLKSAFIIYQGHHGDSGAANADVILPAAAYTEQSGIYVNLEGRPQIAEKAVAPVGVAKEDIEIIKELAGSLKIDIGMDNLQEVRVRLAKEYKIFANIDKIVESKFAKFSFKDKLSKEPITMGPINYYMTDVISKNSVTMAKCVEAKEKRNERAA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit G, NADH dehydrogenase I subunit G, NDH-1 subunit G.
What is the protein family that this protein belongs to?
Belongs to the complex I 75 kDa subunit family.
Protein: DSBD_CAMJE
Sequence: MRIFGIILLSFCLCFASILSLNEAFNVKSNSYNNSISIDIELGKDIYLYSNKLKLYINEKDISSLINLPQSSTRGNENVYYQKLNLALPNLLLERFAKNTTNLIKLEFQGCSEQGLCYNPQTWYFDLISKKDAFEISKPYKAQKTDKKTKIESEESSIANFLATDNFFWILLSFFGYGLLLSLTPCILPMIPILSSLIVAKSNAKFSKKYSFFLSFIYVFFMSLAYAIAGVIASFLGASIQGILQKPIILILFALIFIAFAFAMFGAFRFELPLRFQTFIHKKSEKGKGVVGIAIMGFLSALIVGPCVAAPLAGALIYIANTGNALLGGSALFIMSFGMGIPLLFIGLGLGFIKPGFWMEKVKIFFGFVMLAMAIWILSRIIEENYILIAYGILGVFFSVFMGIFEKSFTIISKIKKSILILILAYSLSIFLGGLFGAKNFLNPLNFNTISASKHALSYDYINNFEQLKQEIQTNTKPIMLDFTASWCENCKLLDELTFSDERIIQKMQNYKLIKVDVSENNNEQIKTMKEFNVFGPPVLIFFENGKEKLKITGFISADDLLKKIEP
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity).
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BBS2_MOUSE
Sequence: MLLPVFTLKLRHKISPRMVAIGRYDGTHPCLAAATQAGKVFIHNPHTRSQHFSASRVFQSPLESDVSLLNINQTVSCLGSGVLNPELGYDTLLVGTQTSLLAYDIYNNSDLFYREVSDGANAIVLGTLGDIAPPLAIIGGNCALQGFDHEGNDLFWTVTGDNVHSLALCDFDGDGKTELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNHAMSIHAFDINSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAVAGVVEGDYRMDGHVQLICCSVDGEIRGYLPGTAEMKGNLLDTSVEQDLIRELSQKKQNLLLELRNYEESTKAELSSPLNEADGQKGIIPANTRLHTALSVNMGNDLQDAHAELGISTSNDTIIRAVLIFAEGIFVGESHVVHPSIHNLSSSLRVPITPPKDVPVDLHLKTFVGYRSSTQFHVFELTRQLPRFTMYALTSPDAASEPVSYVNFSVAERTQRMVTWLNQNFLLPEDSNVQNSPFHVCFTSLRNGGQLYIKMKQSGEITVNTDDIDLAGDIIQSIASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADNSNLIRSLLVRAEDARLMRDMKTMKSRYMELYDLNKDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVISACRDAIRSNNINTLFRIMRVGTAPS
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for proper BBSome complex assembly and its ciliary localization (By similarity).
What are the official names of this protein?
Bardet-Biedl syndrome 2 protein homolog.
What are the subcellular locations of this protein?
Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Protein: ENGB_XANC5
Sequence: MSLLIEQARYHLSAHNARQLPDDGGYEVAFAGRSNAGKSSALNALTRQNALARVSKTPGRTQQLVFFQIQPERYLVDLPGYGYAKVPQDLQAHWQAFIDRYFRTREALRGLVVVMDIRHPLKDYDLQMLGYAAERGLPAHGLLTKADKLGRGQQMQTLQKVKKEVTSRFGDSVTVQTYSGESRQGVDELRAIVGAWLGLDVETTAAE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: HS16A_ORYSJ
Sequence: MSLVRRSNVFDPFSLDLWDPFDSVFRSVVPATSDNDTAAFANARIDWKETPESHVFKADLPGVKKEEVKVEVEEGNVLVISGQRSKEKEDKNDKWHRVERSSGQFMRRFRLPENAKVDQVKAGLENGVLTVTVPKAEVKKPEVKAIEISG
What are the official names of this protein?
16.9 kDa class I heat shock protein 1, 16.9 kDa heat shock protein 1, OsHsp16.9A.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_PSEPG
Sequence: MTIKREMRNDKRAVPKAPINENISAREVRLIGADGEQVGIVSIDEALRIADEAKLDLVEISADAVPPVCKVMDYGKHLFEKKKQANEAKKNQKQIQIKEIKFRPGTEDGDYQVKLRNLVRFLTDGDKAKISLRFRGREMAHQELGMELLKRVEADLAEYGTVEQHPKMEGRQLMMVIAPKKKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.