PharMolix/UniProtQA huggingface dataset:
Protein: ARHGH_HUMAN
Sequence: MADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRASCRPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLFGGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQPQAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGLNLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGSSGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSSGGGSSSETVGRDDSTNHLLLWRV
What is the function of this protein?
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.
What are the official names of this protein?
Rho guanine nucleotide exchange factor 17, 164 kDa Rho-specific guanine-nucleotide exchange factor, p164-RhoGEF, p164RhoGEF, Tumor endothelial marker 4.
Protein: ZP1_MOUSE
Sequence: MAWGCFVVLLLLAAAPLRLGQRLHLEPGFEYSYDCGVRGMQLLVFPRPNQTVQFKVLDEFGNRFEVNNCSICYHWVTSEAQEHTVFSADYKGCHVLEKDGRFHLRVFIQAVLPNGRVDIAQDVTLICPKPDHTVTPDPYLAPPTTPEPFTPHAFALHPIPDHTLAGSGHTGLTTLYPEQSFIHPTPAPPSLGPGPAGSTVPHSQWGTLEPWELTELDSVGTHLPQERCQVASGHIPCMVNGSSKETCQQAGCCYDSTKEEPCYYGNTVTLQCFKSGYFTLVMSQETALTHGVLLDNVHLAYAPNGCPPTQKTSAFVVFHVPLTLCGTAIQVVGEQLIYENQLVSDIDVQKGPQGSITRDSAFRLHVRCIFNASDFLPIQASIFSPQPPAPVTQSGPLRLELRIATDKTFSSYYQGSDYPLVRLLREPVYVEVRLLQRTDPSLVLVLHQCWATPTTSPFEQPQWPILSDGCPFKGDNYRTQVVAADREALPFWSHYQRFTITTFMLLDSSSQNALRGQVYFFCSASACHPLGSDTCSTTCDSGIARRRRSSGHHNITLRALDIVSSPGAVGFEDAAKLEPSGSSRNSSSRMLLLLLAITLALAAGIFVGLIWAWAQKLWEGIRY
What is the function of this protein?
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy.  The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4.  ZP1 ensures the structural integrity of the zona pellucida.
What are the official names of this protein?
Zona pellucida sperm-binding protein 1, Zona pellucida glycoprotein 1, Zp-1.
What is the protein family that this protein belongs to?
Belongs to the ZP domain family. ZPB subfamily.
What are the subcellular locations of this protein?
[Processed zona pellucida sperm-binding protein 1]: Zona pellucida. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Protein: RPOC1_PROM3
Sequence: MTNSNLRTENHFDYVKITLASPDRVMEWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCEKIFGPSKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGFIKLAAPVSHVWYLKGIPSYVAILLDMPLRDVEQIVYFNCYVVLDPGDHKELKYKQLLTEDEWLEIEDEIYAEDSTIENEPIVGIGAEALKQLLEDLNLAEVAEQLREDISSSKGQKRAKLIKRLRVIDNFIATNARPEWMVLDAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKMHQCGLPKEMAIELFQPFVIHRLIRQNIVNNIKAAKKLIQRADDEVMQVLQEVIEGHPILLNRAPTLHRLGIQAFEPKLVAGRAIQLHPLVCPAFNADFDGDQMAVHVPLAIEAQTEARMLMLASNNILSPATGDPIITPSQDMVLGSYYLTAIKPGASVPEFGDQSRTYAGLEDVIHAFEDKRLLLHDWVWVRFNGEVEDEDEIDKPLKAESLSDGTRIEQWTYRRDRFDEDGALISRYILTTVGRVVMNYTIIDAVAAA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: URE2_STRE5
Sequence: MIPGEYHVASEPIDYNGGYEAISLEVKNVGDRAAQVGSHYHFYEANEAGLQFDREKARGKRLDIPAGTAIRFEPGETKTVQLIDFGGKRRIFGFNNKVNGFLD
What is the function of this protein?
Ureolysis may allow urea to be employed as a nitrogen source for growth and produces ammonia which may protect from killing at low pH.
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_ALIF1
Sequence: MKIGIIGAMEQEVAILKDKIEGLSTVTKAGCTFYTGTLNGADVVLLQSGIGKVAAAVGTTLLIAEHNVDVVLNTGSAGGFDSSLNLGDVVISTEVRHHDADVTAFGYEMGQMAQQPAAFIADEKLITTAEQALTEMSDKHAVRGLICTGDVFVCTPERQEFIRTHFPSVIAVEMEASAIAQTCHQFNTPFVVVRAISDVADKESPMSFDEFLPLAAQSSSEMVLNMVTLLK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: YKZ2_YEAST
Sequence: MNVVRVWPFSTRTIPCTTTVAAWWTCCVTVTATGADKATDADAASSETLENFIFVSFIKGMVLFYDGLFRGTMIPRANRSITAICNTLRQAYIYTKIQSIAFERRLCFQNITYREVREIHEMYCK
What are the official names of this protein?
Putative uncharacterized protein YKR012C.
Protein: ITRY_SINAR
Sequence: PAGPFRLPRCRKEFQQAQHLRACQQWLHKQARQSGSGPSPQGPQQRPPLLQQCCNELHQEEPLCVCPTLKGAAKAVKQQIQQQGQQHGQQGQQLQHEIRRIYQTATHLPKVCNIPQVQVCPFNKTMPGPS
What is the function of this protein?
Inhibits trypsin with a Ki of 7 x 10(-6) M.
What are the official names of this protein?
Trypsin inhibitor, TISA.
What is the protein family that this protein belongs to?
Belongs to the 2S seed storage albumins family.
Protein: FXL20_MOUSE
Sequence: MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLSLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.  Isoform 3 regulates neural transmission by binding and ubiquitinating RIMS1, a modulator of presynaptic plasticity.
What are the official names of this protein?
F-box/LRR-repeat protein 20, F-box and leucine-rich repeat protein 20, F-box/LRR-repeat protein 2-like.
What are the subcellular locations of this protein?
Cytoplasm. Note=Isoform 3 is present at the presynaptic membrane.
Protein: HEM1_DESRM
Sequence: MLIAVIGVNHRTAPLEVREKLAFTEWGMKDSLKRLMSYPGIDGCAIVSTCNRTEIYIAPMELDSGMSSVWSFLSEKSGLDISEIKNFTFCHTLYDAIRHLFRVVSGLDSMILGETQILGQVKKAYELALEAKTTNVVLNTLFQQAITTGKRVRTETGIDQNPVSIPYAAVELAKQGFGTLSGRSVLVVGAGEMSELTVVNLVANGVSSVIVSNRSYDRAVQLAEKFDGTAVKFDQLFQYMNRADIVISSTAAQHYVIKTSDMQKVMEQRVDQPIMMIDIAVPRDIDPEVRRIPNVKLYDVDHLQNVVDANLEERRRAAVQAEGIIEEELNEFMRWLSTRFVVPTITALKKMGEEIKQRELVRAYNRLGDLTEREKKIIGSLANSIVNQLLHNPVIKLKQYALTPEGHLYTELTQNIFNLQVEGQKPQTEIIPPEKKKKVAGGSTLNSGWDKGIAAMVADSRSRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RSMI_HYDS0
Sequence: MKLYVVPTPIGNLEDITIRAINILKSVKFIACEDTRRIQILLKHYNIEGKTLLSYYHPKEAIQIRKIISLIRKDEDVALVSDAGTPSISDPGFKLINACIKEDIPVEVLPGPCALITALVGSGLPTHSFMFLGFAPRKSQESFYKEVFSSDTGSYILYESPQRILDTLELISHIEPNITVAIARELTKMHEEYIRGNIKDVIEELKKRNNIKGEIVLVLSKENTLYQESL
What is the function of this protein?
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase I, 16S rRNA 2'-O-ribose C1402 methyltransferase, rRNA (cytidine-2'-O-)-methyltransferase RsmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_NOCSJ
Sequence: MPEHAPDGVRPARPHHKLTADGRRMREVLTYSRRGSRFSPRQQQAWAAYAERWWVPDEAVDDPGFTLAGCFERSAPLIVEIGSGIGESTVALAAARPDHDVVAIEVWRPGVADTLGRIGAAGLSNVRLLSVDAVWSMAHLVEPDSLAALWTFFPDPWHKAKHHKRRLVTASFARLVAGRLAPGAEWRLATDWADYADQMVEVLDAEPMLEGGVVERWAERPVTKFERKGIAAGRAITDLAYRRRGAAR
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: DB132_PANTR
Sequence: MNFLLLVLAALGFLTQVIPASAGGSKCVSNTPGYCRTYCHWGETALFMCNASRKCCVSYSFLPKADLPRLIGNHWQSRRRNTQRKDKKQQTTVTS
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 132, Defensin, beta 132.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: THIE_LIMRD
Sequence: MIFDPKMLQVYLVGGTQDVHNDVVKFLEKVELAMKSGITAFQYREKGNSKLRPNERVDLGLELRTLCTHYGIPLIVDDDYELAQQINADGVHVGQNDTKIEQVSVAVGHQMFIGYSCNTPEQVERANTMDFIDYIGCGPVFPTKSKSDADTAIGINRLERLNMISERPVVAIGGIDEENMKVVHDTGVAGLAVISLVFDSKDLVATVKKMKNLYK
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: EFG_BACAA
Sequence: MAREFSLENTRNIGIMAHIDAGKTTATERILYYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGHRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTIHDRLQANAHPIQLPIGAEDEFNGIIDLVEECAYMYGNDLGTDIQRVEIPEEHKELAEEYRGKLIEAVAELDEEMMMKYLEGEEITVEELKAGIRKATTSVEFFPVICGSAFKNKGVQILLDAVIDYLPSPLDVPAIKGIVPDTDEEVERKSSDEEPFAALAFKIMTDPYVGKLTFFRVYSGVLNSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEKSLVILESMEFPEPVISVAIEPKSKADQDKMGTALSKLSEEDPTFRAHTDQETGQTIIAGMGELHLDIIVDRMRREFKVEANVGAPQVAYRETFRAAAKVEGKFARQSGGRGQFGHVWIEFEPNEEGKGFEFENKIVGGVVPREYIPAVGAGLEDALKNGVLAGYPVVDIKAALVDGSYHDVDSSEMAFKIAASMALKAAVSKCNPVILEPMMKVEVVIPEEYMGDIMGDVTSRRGRVEGMEARGNAQVVRAMVPLSEMFGYATSLRSNTQGRGTFSMVFDHYEEVPKSVSEEIIKKNKGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_MYCGA
Sequence: MAKELTFEQQARAKLLEGINKLAKAVKITAGPKGRNALIEKKYGAPLIVNDGVTIAREIELKDPVENMGAKLIAEAAISTNDIAGDGTTTATILTHEIVNKAIEAINNGTNPVNLRIGIENAAKLVSEYLTSVSKPIKSIDEITQVGAISSGSKFIGELIAKAMDIVGPSGVISIDDAKSFDTTLDTTDGLEFKGGYSSPYMVTDSEKMLSELANPKILVSLNKINTVKEILPLLEASVESSAPLLIVASDIAEDVVTALAINKLRGTLNVVSVKCAEFGEAQKNTLEDLAISVNTILVDSAAGIEFKDLELNKLGSAEKVIISKDKTTVINGACHKDVLAKYLNNLKAKSANLTSKYDKERITKRIANLSNGVAVIHVGGATEVAQKELKLRIEDALNSTKAAVEEGIVAGGGIALMNAIEVLKQVKESNPEIALGYEIVRSSLTAPARQIIENAGQNSSKIINNIINSKQLGYGYNAETNEFVNMINNGIIDPTKVTKTALEKACSVAALLITTEVAINDELKEEKPSLNHL
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR3_HELAN
Sequence: MGQKINPIGFRLGTTQGHHSLWFAQPKNYSEGLQEDQKIRNYIKNYVQKNMKTSSGVEGIARIEIQKRIDLIQIIIYMGFPKILIESRPRGIEELQMNLQKEFNSVNRKLNIAITRIEKPYGNPNILAEFIAGQLKNRVSFRKAMKKAIELTEQADTKGIQVQIAGRIDGKEIARVEWIREGRVPLQTIRAKIDYCSYTVRTIYGVLGIKIWIFIEGE
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ARGR_ECO55
Sequence: MRSSAKQEELVKAFKALLKEEKFSSQGEIVAALQEQGFDNINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFDQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNJ_MYCTU
Sequence: MDVDLPPPGPLTSGGLRVTALGGINEIGRNMTVFEHLGRLLIIDCGVLFPGHDEPGVDLILPDMRHVEDRLDDIEALVLTHGHEDHIGAIPFLLKLRPDIPVVGSKFTLALVAEKCREYRITPVFVEVREGQSTRHGVFECEYFAVNHSTPDALAIAVYTGAGTILHTGDIKFDQLPPDGRPTDLPGMSRLGDTGVDLLLCDSTNAEIPGVGPSESEVGPTLHRLIRGADGRVIVACFASNVDRVQQIIDAAVALGRRVSFVGRSMVRNMRVARQLGFLRVADSDLIDIAAAETMAPDQVVLITTGTQGEPMSALSRMSRGEHRSITLTAGDLIVLSSSLIPGNEEAVFGVIDALSKIGARVVTNAQARVHVSGHAYAGELLFLYNGVRPRNVMPVHGTWRMLRANAKLAASTGVPQESILLAENGVSVDLVAGKASISGAVPVGKMFVDGLIAGDVGDITLGERLILSSGFVAVTVVVRRGTGQPLAAPHLHSRGFSEDPKALEPAVRKVEAELESLVAANVTDPIRIAQGVRRTVGKWVGETYRRQPMIVPTVIEV
What is the function of this protein?
An RNase that has 5'-3' exonuclease and possible endonuclease activity.  Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity).  Has both beta-lactamase and RNase activity, but the physiological relevance of the beta-lactamase activity, i. e.  whether it confers antibiotic resistance, has not been shown (PubMed:21568871).
What are the official names of this protein?
Ribonuclease J, RNase J, Beta-lactamase, Penicillinase.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NELFE_BOVIN
Sequence: MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSSTASQGGVKRSLSEQPVVDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSVSADDDLQESSRRPQRKSLYESFVSSSDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERGGARSSASPPRSRSRDRSRERNRDRDRDRDRERDRERDRDRDRDRERDRDRDRDRDRDRERDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVSIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDVYKENLVDGF
What is the function of this protein?
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity).  The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity).  Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity).
What are the official names of this protein?
Negative elongation factor E, NELF-E, RNA-binding protein RD.
What is the protein family that this protein belongs to?
Belongs to the RRM NELF-E family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to chromatin. Phosphorylation by the P-TEFb complex promotes its release from chromatin.
Protein: TRHO_LEGPH
Sequence: MKDIIIASFYKFIPLNDFESLREPILTKMHEIGIKGTIILAHEGVNGGFAGNREQMNVFYDYLRSDSRFADLHFKETYDNKNPFDKAKVKLRKEIVTMGVQKVDPSYNAGTYLSPEEWHQFIQDPNVILLDTRNDYEYELGTFKNAINPDIENFREFPDYVQRNLIDKKDKKIAMFCTGGIRCEKTTAYMKELGFEHVYQLHDGILNYLESIPESESLWEGKCFVFDDRVAVDQKLDRVYPQLPQDYKYEREQK
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RS14Z_HELPG
Sequence: MAKKSMIAKAQRKPKFQVRAYTRCRICGRPHSVYRDFGLCRVCLRKMGSEGLIPGLRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: LEUD_SYNY3
Sequence: MSQVKQIQGKALPLVGDDIDTDRIIPARFLRCVTFDGLGEHVFADDRQQQGGNHPFDLSQYQDATVLVVNRNFGCGSSREHAPQAIIKWGIKAIIGESFAEIFLGNCLANGVPCVTAPHGQIADLQQAITADPNLAVNLDLTTAAVTYGDRSFPVILSDGAQQMLLDGQWDTCGQLVQNQGKIAATAEKLPYLHWQTSAA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: HIS6_LARHH
Sequence: MLAKRIIPCLDVTAGRVVKGVNFVGLRDAGDPVEIARRYNEQGADELTFLDITASSDARDIILHVIEAVAEQVFIPLTVGGGVRQVEDVRRLLNAGADKVSINTSAVTHPELVAEAAGRFGSQAIVVAVDAKAVTPDNDRWEVFTHGGRKPTGLDAVEWARKMQELGAGEILLTSMDRDGTRIGFNLALTRAVSDAVDIPVIASGGVGNLQHLVDGIKEGHADAVLAASIFHFGDYTVRQAKELMQSQGIEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_ERYLH
Sequence: MAKLSLFERRRQRVRSALRKRSGDKPRLSVHRTGKHIYAQVIDDADGKTLAAASTLGAKGSGANVDAAAKVGKDIAAAAKKAGVTTVVFDRGGFLFHGRVKALADAAREGGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PTH_METFK
Sequence: MNGIRLFVGLGNPGAQYEDTRHNAGFWWIDQLCAQTASKTTLEAKFFGLSGRLNGHADTWLLKPTTFMNASGRAVAALARFYKIPAEQILVVHDELDLPPGAARLKKGGGHSGHNGLKDIAAQLGTNDFWRLRLGIGHPGDRSAVVNYVLNAPLRDEMQQIAYAMDDSMLVLPQLLEGKFEEAMLKLHTKTK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR_CITBB
Sequence: MARLLYVTCNLKPLEISRSLSVGNEFLHEYLKQNPDDEVHFLDLYRDHIQRIDADVLSGWGKLRSGASLATLSDDEQRKVSRIWKHADQFIAADKYVFVTPMYNLGFPAEFKMYIDAVCVVGKTFTYTPAGAVGLLKNQGRKCLHIHSNGGFHYGKEEDHSVPYLKSIMGFMGIEDFESVVLEGVDAMPDLAEEFKQAAVIKAHLAAQSF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: SYG_BACC1
Sequence: MYSMEQVVNLAKHRGFVFPGSEIYGGLANTWDYGPLGIELKNNVKKAWWKKFIQESPYNVGLDAAILMNPKTWIASGHVGNFNDPMIDCKKCKARHRADKLIEDALDAKGIEMVVDGLTFDQMADLMKEHEVKCPDCGSEEFTEIRQFNLMFKTFQGVTESSTNEIFLRPETAQGIFVNFKNVQRSMRKKLPFGIGQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGEDLEWFAFWRETCKNWLLSLGMTEESMRLRDHGEEELSHYSNATTDIEFKFPFGWGELWGVASRTDFDLKRHMEHSNEDFNYIDPQTNERYVPYCIEPSLGADRVTLAFLCDAYEEEQLENDSRTVLRFHPALAPYKAAILPLSKKLSEGATEVFAELAKDFMVDFDETGSIGKRYRRQDEIGTPFCITYDFDSVEDKAVTVRDRDTMEQVRMPISELKGFLEKKIQF
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_RALPJ
Sequence: MTAQLIDGNALAKQLRAEAAQRAAALTARGHQPGLAVILVGEDPASQVYVRNKIKACEDNGFLSSFDRYPADLSEADLLGRIDALNRDPRIHGILVQLPLPKHIDSHKVLEAIAPEKDVDGFHVANAGALMTGAPLFRPCTPYGCMKMLESINYPVRGANAVVVGASNIVGKPMAMLLLQSGATITICNSKTRDLAAHTREADIIVAAVGRRNIITADMVKPGAVVIDVGMNRDDAGKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLINTLEAAERAAEGAALAA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.