PharMolix/UniProtQA huggingface dataset:
Protein: RRP41_YEAST
Sequence: MSRLEIYSPEGLRLDGRRWNELRRFESSINTHPHAADGSSYMEQGNNKIITLVKGPKEPRLKSQMDTSKALLNVSVNITKFSKFERSKSSHKNERRVLEIQTSLVRMFEKNVMLNIYPRTVIDIEIHVLEQDGGIMGSLINGITLALIDAGISMFDYISGISVGLYDTTPLLDTNSLEENAMSTVTLGVVGKSEKLSLLLVEDKIPLDRLENVLAIGIAGAHRVRDLMDEELRKHAQKRVSNASAR
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  SKI6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.
What are the official names of this protein?
Exosome complex component SKI6, Extracellular mutant protein 20, Ribosomal RNA-processing protein 41, Superkiller protein 6.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: MURQ_ECOUT
Sequence: MQLEKMITEGSNAASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHTQVSGGGRLIYLGAGTSGRLGILDASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGAEDSREGGVNDLKNINLTAQDVVVGIAASGRTPYVIAGLEYARQLGCRTVGISCNPGSAVSSTAEFAITPVVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVNIVKNATGCNAEQAEAALIACERNCKTAIVMVLKNLDADEAKKCLDQHGGFIRKALEKE
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: ZAPA_ECO57
Sequence: MSAQPVDIQIFGRSLRVNCPPDQRDALNQAADDLNQRLQDLKERTRVTNTEQLVFIAALNISYELAQEKAKTRDYAASMEQRIRMLQQTIEQALLEQGRITEKTNQNFE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell.
Protein: GLB2_TYLHE
Sequence: SSDHCGPLQRLKVKQQWAKAYGVGHERVELGIALWKSMFAQDNDARDLFKRVHGEDVHSPAFEAHMARVFNGLDRVISSLTDEPVLNAQLEHLRQQHIKLGITGHMFNLMRTGLAYVLPAQLGRCFDKEAWAACWDEVIYPGIKHD
What are the official names of this protein?
Extracellular globin-2A, Erythrocruorin, Globin IIA.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ILVC_SERP5
Sequence: MANYFNTLNLRQQLAQLGKCRFMAREEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIDEKRPSWRKATENGFKVGTYEDLIPQADLVVNLTPDKQHTSVVRAVQPLMKDGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVAEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKGIMAPLFQKHMDDIISGAFSGGMMADWAEDDVKLLNWREETGKSAFENAPQFEGKISEQEYFDHGVLMVAMVKAGVELAFETMVDAGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEFMTTLQAGDLGKSVAGTSVDNAQLRDVNEAVRNHPIESVGRKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RSA3_CANGA
Sequence: MPSQEIFKTKQRKSTNRRRKKRRTAESESDSDSSSSSAASDIEMTNEEEKNDNNSPIISDVELSDLENESEKRDVYELDKETKNKLANIPLTRTEFTSRKDKSVPINLNAVQNKLEMSEEQLKDRIATDQSKEQDAYLNLMFENFGDELNAFRTASDFNSKTVNILANVLKDGTALFDNETLKSIVKSQI
What is the function of this protein?
Required for efficient biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome assembly protein 3.
What is the protein family that this protein belongs to?
Belongs to the RSA3 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MATRX_VSIVS
Sequence: MSSLKKILGLKGKGKKSKKLGIAPPPYEEDTSMEYAPSAPIDKSYFGVDEMDTHDPNQLRYEKFFFTVKMTVRSNRPFRTYSDVAAAVSHWDHMYIGMAGKRPFYKILAFLGSSNLKATPAVLADQGQPEYHAHCEGRAYLPHRMGKTPPMLNVPEHFRRPFNIGLYKGTIELTMTIYDDESLEAAPMIWDHFNSSKFSDFREKALMFGLIVEKKASGAWVLDSVSHFK
What is the function of this protein?
Inhibits mRNA nuclear export through direct interaction with host RAE1-NUP98 complex, thereby preventing interferon signaling and establishment of antiviral state in infected cells.  Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell.  Inhibits host transcription, possibly through interaction with host DNA repair factor IIH/TFIIH GTF2H5 subunit (By similarity).
What are the official names of this protein?
Matrix protein, M protein.
What is the protein family that this protein belongs to?
Belongs to the vesiculoviruses matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein. Host nucleus membrane; Peripheral membrane protein. Host nucleus. Host cytoplasm.
Protein: RK33_CYAM1
Sequence: MAKSKSSRVGISLECTACRANANQPGVNRYRTTKNKKNTPNRLELKKFCPYCGHHTIHREIK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SFH5_VANPO
Sequence: MNFSNDSEEKVFNEIFDQLPTLIKDKCSDYDELYGYKLNYNDSKEKLVEQYYDEDIAKALIFKICKAYQFDKTKIITSIVDILNWRKSFNPLSAAYKETHNEALQTVGLLTSYPDDEPNKRVVTWNLYGQIVKKKELFKDSSKFIRYRIGLMERGLRLLDFNNDANNYMTQVHDYKGVSMFRLDSEIKACTKQVIAIFQKYYPELLYAKYFVNVPSILSWMYDLMKSFIDEQTRKKFVVLNDGNKLGNYLKSCPSENYGGTDKKNNLQKQDVDTPRPTPYALYILESQANEDID
What is the function of this protein?
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity.  Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.  Heme-binding protein that may play a role in organic oxidant-induced stress responses.
What are the official names of this protein?
Phosphatidylinositol transfer protein SFH5, PITP SFH5.
What is the protein family that this protein belongs to?
Belongs to the SFH5 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: NRDR_SHIFL
Sequence: MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEEKLRSGMLRALEKRPVSSDYVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKEFGEEIARLED
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: Y2916_CROS8
Sequence: MPVWVDADACPKVIKEVLFRAAERTETPVILVANQPLRVPPSKFIRARQVPAGFDVADNEIVRCCEPGDLVVTADIPLAAEVIAKGAVALNPRGERYSEATIRERLTMRDFMDTLRASGIQTGGPDALSQRDRQQFAAELDKWLSGRKRQA
What are the official names of this protein?
UPF0178 protein ESA_02916.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: COBS_SULAC
Sequence: MGRILKAILGQLSFFTIIPSPSASLEEIAEFSFISPLMVGIITGIIDWFVVLLGIRLIGSLGALLLIPTVEIIRGFHHLDGLLDMGDALMVGKERRPQVLHDLQTGSGAIGLFLVYFSIFLIATLNLNVSNLWFFLPSEVLARASAISLLGLMKPIPGSYLGKVFHDKMRDKLFSIKFLLVQVFAILFSSPVLILAYVILLLVFYLMAKLVFDGMSGDIVGAIITLSFPIYLLVAEKTCYHYFIFQYSLTLP
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SRP72_SCHMA
Sequence: MANEKAFNLQSAYSDLNKACSAQAYDKIINISGKILTKFPGETKAFQCKVVALIRAEKYEDCLSFLKKNPTLSSHVIFEKAYVEYRLNRLTEAAKTLESEEASDSKVQELKAQVLYRKGDFAGAYAYLRTVIRNSQDDYSEERLANLTAVAAAESCFNNANLDLDVNPQMYEGKFNLACYHLGRGDCYLASRSLDDAENTCNLCLSEDPELTEEERNEELAPIRVQRAYILQLNKEEEEANQVYQSVIRQRASDPALLAVAANNIVCINQDQNIFDSRKRIKMASTDGLQFKLFSRQRTDMLINQALFYWYTNQMEACTAKLRTVSQEELSPRALLLSATQLIKEKNVDKAVLLLQSYLSNFAGSQIDAEIPLALAQLNLRRTSANNLGTGSPQPKNALNVAQMLENILPQHLIHSPGVLSTRIALYLLASSGENAVQTRPDSMKQIVNCIESTLHYYEELGEQNEIYSHLLDNCAAFLLQQGEAKLAAELLEKQLARLESNICQEKQNSLIKQVLVARLVRAYAQFDRPKAEQTCKSLQAKESLSEADVDTLETTFLYGAKSLKRLGKPSEPTDTSDKGKSKRSQIKKSISDIPSSEDPGAQPVISRPKRKKRKVRLPKNYQPGVMPDPNRWLPRRERTHYRGKRRDKRFAPTRGPQGQITGESEWDAAIRSPKVKIPEDGSAGSTPKQMSNTAKQQQKKGRKKGR
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity).  The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity).  The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity).  Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (By similarity).  Can bind 7SL RNA with low affinity (By similarity).  The SRP complex possibly participates in the elongation arrest function (By similarity).
What are the official names of this protein?
Signal recognition particle subunit SRP72, SRP72, Signal recognition particle 72 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the SRP72 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: NU1C_ACOCL
Sequence: MIIATTEIQAINSFSRSESLSLKEVYGLIWLLVPIFTLILVIIIGVLVIVWLEREISAGIQQRIGPEYAGPLGILQALADGTKLLFKEDLLPSRGDISLFSLGPSIAVISTLLSYLVIPFGYHLVLADLSIGVFLWIAISSIAPIGLLMSGYGSNNKYSFSGGLRAAAQSISYEIPLTLCVLSISLLSNSSSTVDIVEAQSKYGFWGWNLWRQPIGFLVFLVSSLAECERLPFDLPEAEEELVAGYQTEYSGIKFGLFYVASYLNLLVSSLFVTVLYLGGWNLSIPYIFIPELFGKNKTGGIFGMTIGILITLAKAYLFLFISIATRWTLPRLRIDQLLNLGWKFLLPISLGNLLLTTSSQLVSL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PRIM_EHV1B
Sequence: MAQRNPEPTIRVLYATDSCVITYSLMLLTGQESSEGVYAISYDWSSELDDLFGRQPRAPNTDAGDGWSSTEQSDADQLATALLQRKPSVSFCLLSGMVGGASDEPQDRVRPMFVCVFSTWTGARALAMTLSHGHPLSSNTLLQALTEEATFLLHNDLILALAITTENVTARSGRTAAAAKYDPQRGSVKAAVIGHSTGRSGLTSVYIHHENKVLTAFRRLYCNNNTTPFWFASKFGPGEREIVLATRYYLFQAIRCSRSGGTYDLQAVKDFIRTYNVPAAPNPTGLDLTHLTSFSLLSKFCCQSWYSRGPCALALPRYVDLRIQADVAEVSALEGFIAADRQGLRVSDREFITYIYLAHFESFNRKQLYDHLLAVSIADPGDIDRITSTSSLKRGTIEKFFAQVRIQLNIRDYIAHNVNPRVVCLPASIGSQYAQDKTYTPSSTTMSTGSAPLGVCDTSTPILKLLDRVESSLAGRGWIQTIVSPNKPQSVHSTPPLDQSRGDELSPGVSSQCGISRRLLHIASSPPVNGRALPLEVLFGQKGVPGPAPVYRVALPSKRQAFAVIANDRWETTTQNLARPGGSKQAYEGGFALAGFGEIDDCSLAWRDLQLTRTTSGVCRTALASSNASAQMYINRNEIFNSSLAVSNIILDVDFGIKRRVPLGMLHLAMRGFRAGIITTLSLIFSDATVQWDSYPCYFYKTSCPPQLVRALHRGEPSSFPDYVDGVEECYMESDFIDDYAAMEEYTDGPMDDYEMMMVDNECPQAACDNTPPNKEGGKTPLQRLDDTDACECTEKMGFRVTVPVPPPYLLAGPEALRGLARIIQQAVVLERTFTESMCSVLRDFSFIDTGVYSHGRSLRLPFFCKVGDSGEVYGGLYPFYVIPPKCNDVDEFVAQHSNPANFHFHAAPRHPTITHVITDLGGDYVSFFERKVARNREAIMTKRATLESLLSSANVSIKSHEAVEAFVVDVVLGEVVSHLATHFPDQSGEYQTVGVHTVVTKPDWILMQINRSGNAYRSQGFSCLRAKHLRSARGLARTFLSISADVHGRLCASISQQCFATKCGNNKMCTIFTLEVDRAK
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Protein: EPOR_MOUSE
Sequence: MDKLRVPLWPRVGPLCLLLAGAAWAPSPSLPDPKFESKAALLASRGSEELLCFTQRLEDLVCFWEEAASSGMDFNYSFSYQLEGESRKSCSLHQAPTVRGSVRFWCSLPTADTSSFVPLELQVTEASGSPRYHRIIHINEVVLLDAPAGLLARRAEEGSHVVLRWLPPPGAPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARMAEPSFSGFWSAWSEPASLLTASDLDPLILTLSLILVLISLLLTVLALLSHRRTLQQKIWPGIPSPESEFEGLFTTHKGNFQLWLLQRDGCLWWSPGSSFPEDPPAHLEVLSEPRWAVTQAGDPGADDEGPLLEPVGSEHAQDTYLVLDKWLLPRTPCSENLSGPGGSVDPVTMDEASETSSCPSDLASKPRPEGTSPSSFEYTILDPSSQLLCPRALPPELPPTPPHLKYLYLVVSDSGISTDYSSGGSQGVHGDSSDGPYSHPYENSLVPDSEPLHPGYVACS
What is the function of this protein?
Receptor for erythropoietin.  Mediates erythropoietin-induced erythroblast proliferation and differentiation.  Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade.  In some cell types, can also activate STAT1 and STAT3.  May also activate the LYN tyrosine kinase.
What are the official names of this protein?
Erythropoietin receptor, EPO-R.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 1 subfamily.
What are the subcellular locations of this protein?
[Isoform EPOR-F]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform EPOR-S]: Secreted.
Protein: RL22_PROM9
Sequence: MTNTSETTKTAIAHGNYVRGSASKVRRVLDQIRGRSYRDALIMLEFMPYRSTDPITKVLRSAVANAEHNYGMDPSTLIISSAWANNGPVMKRYRPRAQGRAFSIKKQTCHISISVESAPTQINAEVQN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SEPP1_HUMAN
Sequence: MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSNGSVTVVALLQASUYLCILQASKLEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQKKLCRKRCINQLLCKLPTDSELAPRSUCCHCRHLIFEKTGSAITUQCKENLPSLCSUQGLRAEENITESCQURLPPAAUQISQQLIPTEASASURUKNQAKKUEUPSN
What is the function of this protein?
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium.  May supply selenium to tissues such as brain and testis.
What are the official names of this protein?
Selenoprotein P, SeP.
What is the protein family that this protein belongs to?
Belongs to the selenoprotein P family.
What are the subcellular locations of this protein?
Secreted. Note=Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium.
Protein: MAP6_HUMAN
Sequence: MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLPRVMIPTAPHTEYIESSP
What is the function of this protein?
Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity).  Specifically has microtubule cold stabilizing activity (By similarity).  Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581).  Regulates KIF5A-mediated axonal cargo transport (By similarity).  Regulates axonal growth during neuron polarization (By similarity).
What are the official names of this protein?
Microtubule-associated protein 6, MAP-6, Stable tubule-only polypeptide, STOP.
What is the protein family that this protein belongs to?
Belongs to the STOP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Note=Localizes predominantly in the proximal part of the axon (By similarity). Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (By similarity). Partially localizes to dendrites in mature neurons (By similarity). Colocalizes with neurofilament (NF)-rich inclusions in spinal cord and brain neurons of patients with amyotrophic lateral sclerosis (ALS) (PubMed:14692697).
Protein: RSBW_BACMK
Sequence: MMEKFEKIEMKIPAKAEYVAIIRLTMAGVANRMGFAYDDMEDMKIAISEACTNIVQHAYKEDVGEITIVFGLYEDRLEIMVADNGVSFNFSTLKSKVGPYDINKPVEHLPENGLGLYLINTLMDDIQIMHDEGMTVLMTKYIQREQVENDGNPISTYRSY
What is the function of this protein?
Negative regulator of sigma-B activity.  Phosphorylates and inactivates its specific antagonist protein, RsbV.  Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
What are the official names of this protein?
Serine-protein kinase RsbW, Anti-sigma-B factor, Sigma-B negative effector RsbW.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: HTPG_SHEPC
Sequence: MSQQETHGFQTEVKQLLHLMIHSLYSNKEIFLRELVSNAADAADKLRYLALTNDALYEGDGELRVRISADKDKGTVTIEDNGVGMTRDGVIEHLGTIAKSGTAEFFKNLSGEASKDSQLIGQFGVGFYSAFIVAKKVTVRTRAAGHKADEAVLWESEGEGSFTVETITKASRGTEITLHLRDEEKEFADDWRLRSIITKYSDHISVPVEMWQEGTPERDGPDGEKIPATEGYWKVMNKATALWMRNKSEISDEEYQEFYKHISHDYTDALLWSHNRVEGKQEYTNLLYIPSKAPWDLWNRDRKHGLKLFVQRVFIMDDAEQFMPSYLRFVQGLIDSNDLPLNVSREILQDNHITKAMRTGITKRVLGMLEKLAKDDAEKYQQFWAEFGQVLKEGPAEDFANRERIAGLLRFASTHTGSAAPTVSLDDYISRMKEGQTKIYYIVADSYDAAANSPHLELLRKKGIEVLLMSERIDEWLINHLTEYKEKQLHSVTRGELELGELEDAAEKEAQEKLAEESAPLIERIKAALGTKVADVKVTSRLTDTPACVVTGEGEMSTQMIKLMQAAGQPVPEVKPTFEVNPAHPLVSRLNDLQDETAFADWSNLLLQQAQLSEKGSLADPSAFIKLMNQMLLANMK
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2229_MYCTO
Sequence: MKAGVAQQRSLLELAKLDAELTRIAHRATHLPQRAAYQQVQAEHNAANDRMAALRIAAEDLDGQVSRFESEIDAVRKRGDRDRSLLTSGATDAKQLADLQHELDSLQRRQASLEDALLEVLERREELQAQQTAESRALQALRADLAAAQQALDEALAEIDQARHQHSSQRDMLTATLDPELAGLYERQRAGGGPGAGRLQGHRCGACRIEIGRGELAQISAAAEDEVVRCPECGAILLRLEGFEE
What are the official names of this protein?
Uncharacterized protein MT2288.
Protein: RL5_CLOBL
Sequence: MMPRLQEKYEKEVVSALMDKFGYKNIMEVPKLEKIVINMGVGEAKENQKSLEAAVEDLAKITGQKPILTKAKKSVANFKIREDMPLGCKVTLRKQNMYEFADKLINVALPRVRDFSGVSSKSFDGRGNYAIGIKEQLIFPEIEFDKIDKIRGMDIIFVTTAKTDEEARELLRFLGMPFAR
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RLMH_KLEP3
Sequence: MKLQLVAVGTKMPDWVQTGFSEYLRRFPKDMPFELVEIPAGKRGKNADIKRILEKEGEMMLAAAGKNRIVTLDIPGKPWDTPQLARELERWKQDGRDVSLLVGGPEGLSPACKAAAEQSWSLSTLTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.