PharMolix/UniProtQA huggingface dataset:
Protein: YPI1_CANAL
Sequence: MSQQRENQRGIVSQTTTTTASPILKLRAQERQARDVSWDANVVDNEHLNKKKTKICCIFHPSDRNCDEEDSSSSSDSSSDSSDNEEDDKNTKIAPKSNNNKKKSKPNAYEVQPHYKNQSKVPGK
What is the function of this protein?
Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.
What are the official names of this protein?
Type 1 phosphatases regulator YPI1.
What is the protein family that this protein belongs to?
Belongs to the YPI1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y106_MYCTU
Sequence: MRTPVILVAGQDHTDEVTGALLRRTGTVVVEHRFDGHVVRRMTATLSRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAPWLEPQPICWAIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSLGEDELPDGRTVAQVTVGQAEFADLLVLTHPEPVAVAVLRRLAPRARITGGVDRVELALAHLDDNSRRGRTDTPHTPLLAGLPPLAADGEVAIVEFSARRPFHPQRLHAAVDLLLDGVVRTRGRLWLANRPDQVMWLESAGGGLRVASAGKWLAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVLVCGADPTDIVNALNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAGEFSAHRNSGESR
What is the function of this protein?
Zinc chaperone that directly transfers zinc cofactor to target proteins, thereby activating them.  Zinc is transferred from the CXCC motif in the GTPase domain to the zinc binding site in target proteins in a process requiring GTP hydrolysis.
What are the official names of this protein?
Zinc chaperone Rv0106.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
Protein: ISPF_VIBPA
Sequence: MIRIGHGFDVHKFGGEGPVIIGGVAIPYEQGLIAHSDGDVALHALTDALLGAIAAGDIGRHFPDTDDKWKGANSRELLKDVYRRVKEQGYRLGNADVTIMAQAPKMAPHIDAMCAAIAEDLETDISNINVKATTTERLGFTGRKEGIATEAVVLLFKQ
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: TPC1_NEOFI
Sequence: MSAGGEHLKDEGTRRQVVLSGGIAGLVSRFCVAPLDVVKIRLQLQIHSLSDPASHRDVVGPIYKGTLSTMRAIIKQEGITGLWKGNIPAELMYVCYGALQFTAYRTTTQVLAQLDPHRLPPALESFVSGAVAGGLATASTYPLDLLRTRFAAQGTERIYTSLLASVQDIARNEGPAGFFRGCSAAVGQIVPYMGLFFATYESLRPVLSGLENMPFGSGDAAAGVIASVLAKTGVFPLDLVRKRLQVQGPTRTLYVHRNIPEYRGVFSTIAMIVRTQGVRGLYRGLTVSLIKAAPASAITMWTYERSLKLLHDFRVAE
What is the function of this protein?
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
What are the official names of this protein?
Mitochondrial thiamine pyrophosphate carrier 1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PHUZ_BPDPK
Sequence: MMSKVKTRIYFCGGAGFRIGELFHGYHEDVCYIDTSVQNKHKHNTDDNTIIIEADTKLADQTARKRAIGMGKDRKAAAELISAHIPAIAHHFPAGDTNIVVYSMGGASGSTIGPSLVSHLQQQGEVVVSVVIGSYDSDISLRNSSGSLKTFEGVSSVSKVPMIINYHENVEGIPQSMVNQNILEVLNALVILFNQEHQSLDLMDITNWAHFHKHHDVPVQTVQLHVCFDRQEAQAILDPISIASLYTDPDRDVSISTVLTRTTGYADPEKYDFDQMHFVINGLSIEDIRKRLEERREMMNRAKANMRKRQSTLDVDDQATSSGLVFD
What is the function of this protein?
A tubulin-like GTPase that forms filaments, which are required for positioning viral DNA and capsids in the middle of the host cell for optimal replication.  The motor component of a partition system which pushes phage DNA (encased by protein gp105) to the center of the bacterial host cell (PubMed:28813669).  Also required for movement of phage capsids to the vicinity of the viral DNA and rotation of the encased viral DNA at midcell (PubMed:28813669).  Forms filaments during the lytic phase, which position phage DNA at the center of the bacterial host cell (PubMed:28813669).  Filaments have a three-stranded intertwined architecture and form a spindle-like cytoskeleton within the infected cell (PubMed:23528827).  Has GTPase activity (Probable).  Filaments grow at the plus end and depolymerize at the minus end, a process called treadmilling, and switch from growing in a polar manner to catastrophic depolymerization, i. e.  they display dynamic instability, like tubulin (By similarity).  In infected host cells the filament ends close to the cell pole are relatively stable, while the other end near the phage DNA is highly dynamic.  Both capsid movement and DNA rotation probably require treadmilling (By similarity).
What are the official names of this protein?
Phage tubulin-like protein, PhuZ, Phage tubulin/FtsZ, Tubulin-like protein TubZ.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family. PhuZ subfamily.
What are the subcellular locations of this protein?
Host cytoplasm. Note=In infected host cells forms a spindle-like structure emanating from each cell pole.
Protein: DNLJ_DEHMB
Sequence: MEDMFSPLIEVENLRREINRHNQLYYVQDNPEISDAQYDTLIRRLKELEEAHPELVTPDSPTQRVGAEPLKAFGIVNHPYPLLSLANAFSDTELEAWYQRVKKLLGNIPFQIDCEPKMDGLAVALTYRNGKFATGATRGDGFQGENITRNLRTIHSIPLNAEPNAPPVFEVRGEVYLSKNGFAKLNRERADKGLPLFANPRNAAAGSLRQLDPSVTAERPLDIFIYALGYSEDSLLPDSHWQILDYFSKIGFRINPLNRLVNTLEEAKEYYRQMAANRASLPYEADGVVFKVDSVSLQHRLGDVGREPRWAIAYKFPAEQVMTRLKKIGISVGRTGTLNPFAVLEPVNVGGVVVKQAALHNEDDILRKDIREGDTVIIQRAGEVIPEVVAPVLSKRNPESKPFRMEESLFNPNLNRTACPVCGGEIYRPAGEAMHYCANVSCPAQFERQLEHFVSRGAMDIRGIGESLSVILAQQGLVKNVSDLYYLTTADLLQLPRMGEKSADNIIDAIADSKTRPLDRVIFGLGVRHVGNETATLLSRHYGNIWALAKTGLGELQTIPDIGDKIASSIVAYFSEEKNVAVIRRLEEAGVRLTSDQKPVNKNMPFSGMEFVVTGKLESFSREEAQEKIRSLGGTAKDNVTKATNYLVVGADAGSKLTKARSMGVKELSEREFINMLEQS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: FLGH_AGRVS
Sequence: MIKRSAVVLMAVILTGCGNKTLEEVGNAPAMSPVGSGLRYNQAPQLASYPKQTKAVSNGYSLWNDSQAALFKDSRAINVGDLLTVNISIADKAKFKNDTSRSRKNSTSLTWSTVINLFGITPPDSSGDMSTDSNSSSDGKGSVDRSETLTLMVAAVVTSILENGNLLISGSQEVRVNHEVRILNVAGIVRPQDVDAKNTISYEKIAEARISYGGKGRLTEVQQPPVGQQVVDMFSPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: RS12_AMOA5
Sequence: MATIQQLIRKGRKKIKYNSKSPALGGCPQRRGICTKVTTMKPRKPNSSMKKVAKVRLSNGKEVNVYIPGEGHNLQEHSAVLIQGGGVNDLPGINYRIIRGTLDTAGVNGRIQSRSRYGAKKGAAKQAAAAKSKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: YAF7_SCHPO
Sequence: MEYYIRETLITDFQDVKTLKNKRKCFSFFFELRLFSPQCLFIVYFFYLLHVRINTSPLFIKTTTRPTALIHITKYSEALASRLLKGHMTQLSLRTILPPAHTKNLHRQQPTTWLDS
What are the official names of this protein?
Uncharacterized protein C29E6.07.
Protein: Y101_METAC
Sequence: MKEKREFRDYLSDIFDAIEKIENFTQDISFDAFVEDEMRVFAVVRALEIIGEAAKNVPLEIKENYPSVPWKEMARTRDKLIHSYFGVDLNVVWKTVNKNLPPLKDQISEILKDLGNTSS
What is the function of this protein?
Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase.  Probably neutralized by cognate antitoxin MA_102.  Neutralization may be due to AMPylation by MA_102.
What are the official names of this protein?
Putative RNase MA_0101, Putative toxin MA_0101.
What is the protein family that this protein belongs to?
Belongs to the HepT RNase toxin family.
Protein: GLSA_KLEP7
Sequence: MATVINNAMLEAILAEIRPLIGRGKVADYIPALASVSGDKLGIAISTVDGQHFAAGDAHERFSIQSISKVLSLVVAMNHYQEEEIWQRVGKDPSGQPFNSLLQLEIEQGKPRNPFINAGALVVCDMLQSRLSAPRQRMLEIVRRLSGVADIAYDPVVARSEFEHSARNAAIAWLMKSFGNFHNDVATVLQNYFHYCSLEMSCVELARTFLFLADRGIAPHLDAPVIAPIQSRQVNALMMTSGMYQNAGEFAWRVGLPAKSGVGGGIVAIVPQEMAIAVWSPELDDAGNSLAGVAMLEKLTQRMGRSVF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: CLPX_FRACC
Sequence: MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELSESSELKWDELPKPREIYEFLDSYVVGQETAKKTLSVAVYNHYKRVQAGGSSGDGSKGEVELAKSNILLLGPTGCGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLDRIIESRIGKKSLGFRAVLHGKDDPDGSDVFGDIMPEDLLKYGMIPEFIGRLPVITSVSNLDREALIRILTEPKNALVRQYKRLFELDSVDLDFTSDALEAIADQAILRGTGARGLRAIMEEVLLSVMYDIPSRKDVARVVVTREVVLEHVNPTLVPRDVVSKRAPRQEKSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: PSBH_ORYSA
Sequence: MATQTVEDSSRPGPRQTRVGNLLKPLNSEYGKVAPGWGTTPFMGVAMALFAVFLSIILEIYNSSVLLDGILMN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H, Photosystem II 10 kDa phosphoprotein.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: AKTIP_RAT
Sequence: MNPLWSMSSGSVRKRAEGEEKTLAGDVKTSPPRSAPKKQLPSIPKNALPISKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTMVVKQKLPGVYVQPSYRSALVWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLLFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDTTSPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPDEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT
What is the function of this protein?
Component of the FTS/Hook/FHIP complex (FHF complex).  The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).  Regulates apoptosis by enhancing phosphorylation and activation of AKT1.  Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.  FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
What are the official names of this protein?
AKT-interacting protein, Fused toes protein homolog.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: NIFD_ANASL
Sequence: MTPPENKNLVQENKELIQEVLKA
What is the function of this protein?
This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
What are the official names of this protein?
Nitrogenase molybdenum-iron protein alpha chain, Dinitrogenase, Nitrogenase component I.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: GVPL1_HALSA
Sequence: MTDHRPSPEEEQTTANEERTVSNGRYLYCVVDTTSSESATLSTTGVDDNPVYVVEADGVGAVVHDCETVYETEDLEQVKRWLVTHQQVVDAASDAFGTPLPMRFDTVLEGGDASIERWLEDHYEGFRDELASFAGVWEYRINLLWDSAPFEETIADRDDRLRELRQRQQQSGAGKKFLLEKQSDQRLQELKRERRTELADQLKEAITPVVNDLTEQDTNTPLQDEHSSIEKEQIVRFAVLADEDDETALGDRLDTIVEHEGVEIRFTGPWPPYTFAPDIGK
What is the function of this protein?
May play a structural or regulatory role in gas vesicle synthesis.
What are the official names of this protein?
Protein GvpL 1.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: MDTL_SALDC
Sequence: MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGAIVFMMASLLCSRASEGSLFLSGRFLQGIGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPVRLAPRDLSRSSPAAESLINRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLIFSVTPNRSVAEHEEIPYQSRP
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YIDE_SHISS
Sequence: MSDIALTVSILALVAVVGLFIGNVKFRGIGLGIGGVLFGGIIVGHFVSQAGMTLSSDMLHVIQEFGLILFVYTIGIQVGPGFFASLRVSGLRLNLFAVLIVIIGGLVTAILHKLFDIPLPVVLGIFSGAVTNTPALGAGQQILRDLGTPMEMVDQMGMSYAMAYPFGICGILFTMWMLRVIFRVNVETEAQQHESSRTNGGALIKTINIRVENPNLHDLAIKDVPILNGDKIICSRLKREETLKVPSPDTIIQLGDLLHLVGQPADLHNAQLVIGQEVDTSLSTKDTDLRVERVVVTNENVLGKRIRDLHFKERYDVVISRLNRAGVELVASGDISLQFGDILNLVGRPSAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPVFVPGFPAALKLGLAGGLLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLSVVGLKSGGDFVNTLVNGEGLSWIGYGALITAVPLITVGILARMLAKMNYLTMCGMLAGSMTDPPALAFANNLHPTSGAAALSYATVYPLVMFLRIITPQLLAVLFWSIG
What are the official names of this protein?
Putative transport protein YidE.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MDTB_ECOBW
Sequence: MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA
What is the function of this protein?
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL6_NITMU
Sequence: MSRVGKNPVSVPANVEVRLSGSEVEVKGPLGMLRHELVSDISIERKGESLLVKAADDSKHANAMWGTTRALLANMVKGVTTGFEKRLILVGVGYRAQAADNVLNLTLGFSHPIAHKMPEGIKVETPSQTEVVIKGMDKQQVGQVAADVRAYREPEPYKGKGVRYADEVIVLKETKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: CH601_PROMA
Sequence: MSKIIRSSDESRGALENGVNSLADAVKVTIGPKGRNVVLEKKFGAPDIVNDGVTIARDIELENPFENLGAKLIEQVASKTKDKAGDGTTTATVLAQVMVHEGLKNTAAGASPIEIRRGMEKAVSHIVDKLQQQSKKISGDKVLQVATVSSGGDEEIGAMVAEAMDKVSVDGVITVEESKSLNTELEITEGMAFDRGYSSPYFVTDAERQICEFENPLLLITDRKISSIADLVPVLETVQKSSSPLVILAEEVDGEALATLVVNKNRGVLQVASVRAPSFGERRKAALADIAVLTKGTLISEDKAMTLDKVSLADLGKARKITITKESTTIVANDDTKKEVASRVASIKRELDQTDSDYDKEKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNATRAAVEEGIVAGGGSTLIKLGEELDSLSKSLDGDQATGVDIIKKALSAPAKQIALNAGENGDVVVSEIQRLGKGFNAATGQYEDLISAGIIDAVKVIRLALQDAVSIASLLITTEVIIADKPEPPSPAGGEGGGDPMGGMGGMGGMGGMGMPGMGGMGMPGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOLC_BACAN
Sequence: MNPLIFKENRPFDLIAVGRLCVDLNANETQRPMEETRTFTKYVGGSPANIAIGAARLGLQTGFIGKVSDDQMGRFITGYLKDNKINTDQIPIDCTGAVTGLAFTEIKSPEDCSILMYRDNVADLNLDPTEVSEDYIKQSKALLISGTALAKSPSREAVFLALEYARKHDVVVFFDVDYRPYTWQSEAETAVYYNLAAEKSDVIIGTREEFDMMEKLLNYEKSNDQVTAERWFSHHAKIVVIKHGGDGSIAYTRDGQSHRGGIFKTKVLKTFGAGDSYASAFIYGLMQGLEIPQAMRLGGASASIVISKHSCSDAMPTRAEISAFMETAEELV
What is the function of this protein?
Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).
What are the official names of this protein?
5-dehydro-2-deoxygluconokinase, 2-deoxy-5-keto-D-gluconate kinase, DKG kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: JHD1_YEAST
Sequence: MQDPNICQHCQLKDNPGALIWVKCDSCPQWVHVKCVPLKRIHYSNLTSSEVLSYPNSAKQIKSYRCPNHKEGEYLTAYALITQKGKRQRNKENPEDSHINKRYNFRKKKLLDYIALNEGESKRDKMNHPHKESFMKSFEKWKNGSNIINAADFAEKFDNIDVPYKIIDPLNSGVYVPNVGTDNGCLTVNYITEMIGEDYHVDVMDVQSQMNENWNLGSWNEYFTNTEPDRRDRIRNVISLEVSNIEGLELERPTAVRQNDLVDKIWSFNGHLEKVNGEKAEENDPKPKVTKYILMSVKDAYTDFHLDFAGTSVYYNVISGQKKFLLFPPTQSNIDKYIEWSLKEDQNSVFLGDILEDGIAMELDAGDLFMIPAGYIHAVYTPVDSLVFGGNFLTIRDLETHLKIVEIEKLTKVPRRFTFPKFDQVMGKLCEYLALDKNKITSDVSDGDLLSRTTNCAIQSLHAYVIKPEVKYKPLNFTSKKHLAKALADLIS
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.  Does not demethylate H3 'Lys-4' nor 'Lys-79'.
What are the official names of this protein?
JmjC domain-containing histone demethylation protein 1, Jumonji/ARID domain-containing protein 1, ScJHDM1, [Histone-H3]-lysine-36 demethylase 1.
What is the protein family that this protein belongs to?
Belongs to the JHDM1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: G6PD_BUCBP
Sequence: MKNKNSGYDLVIFGAKGDLSCRKLLPSLYQLEKKNKLCTHTRIIGVGRANWDKIIYTNVVYKSLIKFLNETIIESIWKKFSSRLEFCNLDINCLHNFKKLKQIIQQNNNIIINYLAMPPHTFGNICLGLESINLNLEPTRIIIEKPLGSSLKTSININNKIGKFFKEKQIFRIDHYLGKETIQNLLAFRFSNSLFYYNWNNKFIDHVQITVSETIGVEGRFNYFDTVGQIKDMVQNHLLQILTITTMSTPIDCHENSIRDEKVKILKSLRPFNINNIHKNVILGQYTSGIINQKKVKSYLDETNNQEYQMNKYTETFVSMKIYIDNDQWSGVPFYLRTGKRLPKKCSEIVIFFKTPPLNIFSKNYNTLSKNKLILSLQPNEAIKIYILNKKPKLTSQYKLDLITLDFNYSKFYKKIQLSDAYEKLLLESMKGIQSLFVRRDEVELAWKWIDSTLQCLHLKPRLPDLYPAGTWGPARSKTMINNDGYEWNE
What is the function of this protein?
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: MNME_THEP3
Sequence: MVFDTIAAISTFPGEAGIGIVRLSGDDALEIISKIFKPYKSKDIKKVKSHTLHYGHIVDPETEEVYDEVLVSIMKKPNTYTREDIVEINCHGGIVVTSKILELVLKQGARLAEPGEFTKRAFLNGRIDLSQAEAVIDIIRAKTMLANRYAQKQLVGYVGSKIKEMKDKIMGLLVHLLALIDFPEEDVEELERKEILETAKEIVEDIDKLIASSESGRIIREGLKTAIIGKPNVGKSSLLNALLKENRAIVTDIPGTTRDIIEEYVNVKGIPIKLIDTAGIRDTDELVEKIGVTKSKEVLAEADLILFVLDASRELTKEDYEIFDILTGKNIIFVLNKIDLPKKIDEKELKDLTKDGIIIEVSTVEKIGLEELENTIYNLVFRGDISLREDEIVINSRHKEALINAKKYMESCVEAIEGGYSEDLITIDLNAALDQLGKITGETATEDLINEIFERFCVGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUTC_KLEP7
Sequence: MPKQVIIPPGTTAPIAPFVPGTLADGVVYVSGTLPFDKQNNVVHIGDPKAQTRHVLETIRSVIETAGGSMADVTFNSIFITDWTNYAAINEVYAEFFPGDKPARFCIQCGLVKPDALVEIASVAHIGTPT
What is the function of this protein?
Involved in pyrimidine catabolism.  Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously.  RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.
What are the official names of this protein?
3-aminoacrylate deaminase RutC, 3-AA deaminase.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: METK_ACIF5
Sequence: MSKSHLFTSESVSEGHPDKVADQISDAILDAILAQDPRGRVAAETLITTGLIVLAGEITTTAVVDYADVARQTVRRIGYNSSDMGFDWASCAVVQTLDKQSPDIAQGVDEGAGLDLDQGAGDQGLMFGFACDETDVLMPTPIYFAHRLTERQAMVRKDGRLPWLRPDAKSQVTVRYEDDRPVAIDTVVLSTQHAPDISHADLVEAVREEIIKPVLPPEMIHKDTKYLINPTGRFVIGGPVGDCGLTGRKIIVDTYGGQGSHGGGAFSGKDPSKVDRSSSYAGRYVAKNIVAAGLARRCEVQVAYAIGVSQPVSLMVDTFGTGVIDDDRIAALVQEHFDLRPKGIIQMLDLLRPIYAKTAAYGHFGREEPEFTWERTDKAAVLRDAAGLR
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VME1_CVH22
Sequence: MSNDNCTGDIVTHLKNWNFGWNVILTIFIVILQFGHYKYSRLFYGLKMLVLWLLWPLVLALSIFDTWANWDSNWAFVAFSFFMAVSTLVMWVMYFANSFRLFRRARTFWAWNPEVNAITVTTVLGQTYYQPIQQAPTGITVTLLSGVLYVDGHRLASGVQVHNLPEYMTVAVPSTTIIYSRVGRSVNSQNSTGWVFYVRVKHGDFSAVSSPMSNMTENERLLHFF
What is the function of this protein?
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
What are the official names of this protein?
Membrane protein, M protein, E1 glycoprotein, Matrix glycoprotein, Membrane glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the alphacoronaviruses M protein family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.