PharMolix/UniProtQA huggingface dataset:
Protein: XPOT_NEUCR
Sequence: MDAQFEKAIEIAFDPRSSHALKSQALEFLNQVRTDVQAWRICAALFTRSPRASDIVRHVSLEMVNNAVHSQGLDAPDLAFVKNSLLDYITRTYGPNAQDQADPANVQNKLTQTLTYLFVALYGEGWETFFDDFLALTSSQNGASRDNLSGVMLYLRILSSVHDEIADLMISRQGNESKRNNDLKDLIRERHMQKIAMSWQDILAQWTNKHDGVVELTLKVIGKWVSWIDISLVVSQDMQNLILPLVGRVNNTSNNIDTVRDTAIDTLTEIVAKKMGPSHKMELISFLNLGGIITELLASQGLHEFKGTSRYDNDLAEVVAKLLNTIMTDVVRVLEDNKVDAETRAKAERHLQDFLPALLRLFSDEFDEVCSTVIPSLTDLLTFLRRVGTLPDSYSQMLRPILSAIVAKMRYDETSSWGTEDGESDEAEFQELRKRLQILQKSVAAVDQTLYIEFLSNLVGNMFATLEQQGPQMDWRDLDLALHEIYLFGELALPNAGLAHKSEPNVVATERLAVMMSKMVESGIANFPHPAILLQYMEICVRYHAFFESHHQYIAPVLENFVHLIHHEHPRVRTRSWYLFLRFVKQLRAQVGNVAKTVIQSISDLLPIKAEVPSTEAEDDMSSDESDHSADAIFNGQLYLFEAIGCISSTSTTPETDQALYARSVMEPLFSDMSVHLPRAKSGDAQAILQIHHIIMALGTLANGFADPNQSQNPNNQRTPPQAVSAEFSRASEAILVALNELNTNGEIRAACRSAFSRLLGVLGATILPQLPQWIEGLLSQSSSKDEMAFFLRLLEQIVYNFKGEIYNILDLLLTPLLQRVFAGLSEPINGTDDEIQLQELRREYVSFVQVILINELGGVLVSTSNQGVFESLVNSIMTIAKTIVHGNIVASRISFNVLARMAQQWGGPDVATIGENPTANGVPAPAFPGFDQFMLTQFHAACWEVMQDINFRPYADAQTRQILNEITGLEQIIYLKTGEKFISHCQTVTFPAVGMGAEDFLRALTSSTDRKAVMAYLQQLLKSRR
What is the function of this protein?
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.  Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
What are the official names of this protein?
Exportin-T, Exportin(tRNA), Karyopherin-beta, tRNA exportin.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: QUEA_NITMU
Sequence: MKIQDFDFDLPPELIAQFPAEKRGNSRMLHLDATSGALQDRMFADLPSYLRPGDVIVFNDTRVIKARLYGVRDTGGRVEVLVERVLDSHCALAAIRASHSPKPGSKLFLAGAIEVTVLSREHGFYILQFEHESGVMELLERYGNLPLPPYISRPVEKSDELRYQTVYAARPGAVAAPTAGLHFDEHMLGLLRKMGVVMAHVTLHVGSGTFQPVRVENIADHRMHSEVFYVSAETVECIRHAKAEGGRVLAVGTTSLRALEAAAAFAGERAEADNGDGVRIKCGAGETDIFITPGYQFRVVDCLLTNFHLPRSTLLMLVSAFGGVENIRCAYRHAIKERYRFFSFGDAMLIGRAEGI
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_RICPR
Sequence: MLKYGVIIIGGGHAGVEAAAASARLGVHTLLITLKPENLGEMSCNPAIGGIAKGTLVKEIDALDGLMGFVIDKSGIHYKMLNETRGPAVWGPRAQADRKLYKKVMYQILTNYRNLDILYAKVEDIQIKSSKVEAVILSNGSKIFCQKVVLTTGTFLSGFIHIGSIKMPAGRIYEEPSYGLSNTLKRLGFKIARLKTGTPPRIDGRTIDYSKTALQQGDQIPRPFSELTDVIDVPQINCFITKTTSETHDIIRENLDKSAMYSGQIEGIGPRYCPSIEDKIVKFSTKLEHRIFLEPEGLEDYTIYPNGISTSLPEEVQYKLIKTIPGLENAQVLRPGYAIEYDYVDPREINVTLETKKITGLYFAGQINGTTGYEEAAGQGIIAGINAALSVKDQAPFILTRATSYIGVMIDDLTTFGTVEPYRMFTSRSEYRLSLRADNADLRLTELGIKIGVITEKRKKFFTKKCKNIEKTKLLLNNLSLTTSKLAKMGIQVAQDGKYKTILDLFKIPSFNVEQAIKIFPILKKQNNNILQLLYIEAKYASYLTRQYADINLFQSEEIQLIPKNIDYFKIPSISLEIQEKLSYHKPATIGVARRISGITPASITAIIIYLKTKYSDESSK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYC_LASSJ
Sequence: MGQIVTFFQEVPHVIEEVMNIVLIALSVLAVLKGLYNFATCGLVGLVTFLLLCGRSCTTSLYKGVYELQTLELNMETLNMTMPLSCTKNNSHHYIMVGNETGLELTLTNTSIINHKFCNLSDAHKKNLYDHALMSIISTFHLSIPNFNQYEAMSCDFNGGKISVQYNLSHSYAGDAANHCGTVANGVLQTFMRMAWGGSYIALDSGRGNWDCIMTSYQYLIIQNTTWEDHCQFSRPSPIGYLGLLSQRTRDIYISRRLLGTFTWTLSDSEGKDTPGGYCLTRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIQRLKAEAQMSIQLINKAVNALINDQLIMKNHLRDIMGIPYCNYSKYWYLNHTTTGRTSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYMERQGKTPLGLVDLFVFSTSFYLISIFLHLVKIPTHRHIVGKSCPKPHRLNHMGICSCGLYKQPGVPVKWKR
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1 (PubMed:26849049, PubMed:35173332).  The glycoprotein spike trimers are connected to the underlying matrix (PubMed:26849049).  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm.  Membrane fusion is mediated by irreversible conformational changes induced by acidification (PubMed:31004664).
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: DNLJ_STRZP
Sequence: MNKRMNELVALLNRYATEYYTSDNPSVSDSEYDRLYRELVELETAYPEQVLADSPTHRVGGKVLDGFEKYSHQYPLYSLQDAFSREELDAFDARVRKEVAHPTYICELKIDGLSISLTYEKGILVAGVTRGDGSIGENITENLKRVKDIPLTLPEELDITVRGECYMPRASFDQVNQARQENGEPEFANPRNAAAGTLRQLDTAVVAKRNLATFLYQEASPSTRDSQEKGLKYLEQLGFVVNPKRILAENIDEIWNFIQEVGQERENLPYDIDGVVIKVNDLASQEELGFTVKAPKWAVAYKFPAEEKEAQLLSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIAEKDIRKDDTVIVYKAGDIIPAVLRVVESKRVSEEKLDIPTNCPSCNSDLLHFEDEVALRCINPRCPAQIMEGLIHFASRDAMNITGLGPSIVEKLFAANLVKDVADIYRLQEEDFLLLEGVKEKSAAKLYQAIQASKENSAEKLLFGLGIRHVGSKASQLLLQYFHSIENLYQADSEEVASIESLGGVIAKSLQTYFATEGSEILLRELKETGVNLDYKGQTVVADAALSGLTVVLTGKLERLKRSEAKSKLESLGAKVTGSVSKKTDLVVVGADAGSKLQKAQELGIQVRDEAWLESL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: HP55_TAMSI
Sequence: MPSSISWGLLLLAALSCLGPGSLAQDAQETEASKQDQEHPASHRIAPHLAEFALSLYRVLARQSNTTNIFFSPVSIASALAMLSLGTKGDTHTQILEGLDFNLTEMAEADIHQGFQNLLQTLNRPNTQLQLTSGNVLFIHQNLKLLDKFLENIKSLYHSGAFPTNFTNTEEARQQINSYVEQGTQGKIVELVKELDRDTVLALVNYIFFKGKWLKPFNVKNIREEDFHVDEATTVRVPMMYRVGMFPVHYCRTLASLVLQMDYLGNATAIFLLPDKGKMQHLEDTISTEILSKLLKDRQTSKYQVYFPRVSISGTYDLKDVLSSLGITRVFSRVADLSGVTEDAPLTVSKVLHKAVLDMDEEGTEAAGGTVLGAEAMLQAPIMKFDRPFLVVIYEHNTKSPLFVGKVVNPTQQ
What is the function of this protein?
Protease inhibitor.
What are the official names of this protein?
Hibernation-specific plasma protein HP-55, CM55-ML, Hibernator-specific blood complex, 55 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: BRXA_BACSU
Sequence: MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGTTLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEPSSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC
What is the function of this protein?
S-bacillithiolation is the formation of mixed disulfide bonds between protein thiols and the general thiol reductant bacillithiol (BSH) under oxidative stress.  BSH is an equivalent of glutathione (GSH) in Firmicutes.  This protein is a dithiol bacilliredoxin, which debacillithiolates (removes BSH) the S-bacillithiolated OhrR (OhrR-SSB) in vitro and in vivo NaOCl-generated S-bacillithiolated MetE (MetE-SSB).  Involved in maintaining redox homeostasis in response to disulfide stress conditions (PubMed:24313874).  Has a redox potential of -130 mV.  Displays weak protein disulfide isomerase activity in vitro (PubMed:19653655).
What are the official names of this protein?
Bacilliredoxin BrxA, Brx-A, Dithiol bacilliredoxin, UPF0403 protein YphP.
What is the protein family that this protein belongs to?
Belongs to the bacilliredoxin family.
Protein: SIS8_ARATH
Sequence: MKVKEETLKNLGDGVVLRPVDHCSSIWSMKMNMKNFLKKLHISPNQSDEAEGSISTTKSNHHKSIDVSSSSSPRSHHSNSPEIKPFSGLSNWLSSVGHRKIPSPPNSFNAKNRAATVDDTVVVNGSEHVDLGSKDPAVEEENQIQLALELSAREDPEATQIEAIKQFSLGSCAPENSPAELIAYRYWNYNCLGYDDKILDGFYDLYGVLNASSAERIPPLLDLQGTPVSDGVTWEAVLVNRSGDSNLLRLEQMALDIAAKSRSVSSSGFVNSELVRKLAILVGDYMGGPVVHPESMLRAWRSLSYSLKATLGSMVLPLGSLTIGLARHRALLFKVLCDSVGVPCRIVKGQQYTGSEDVAMNFIKADDGREYIVDLMGDPGTLIPADAAGLQIDYDESAYSASPGDNDSIHVASSSNGIESSYEENTEFRTGEHRSSTKSSGERNQSGGGGDLIVHPNISREDVKNQKKVEKAPFQNLSSRPIHSFTHMRSPSWTEGVSSPAAQRMKVKDVSQYMIDAAKENPRLAQKLHDVLLESGVVAPPNLFSEVYPQQLEATVESKNSTEAKKERGKDLETTQEGRHQNGFGPVRFLPPLPRVQSKTNAHDQRDNGKVVSQSDSSHSEASSTEYARTVPAAVAAAAVVASSMVAAAAAKSANSDSSPIELPAAAAATATAAAVVATAAAVSRQLELGSNSDGDDGSGGHEPQGSGDSNHGPNSGGERISDKSIGNESSKSDCDDVSDCEILWEEITVGERIGLGSYGEVYRGDWHGTEVAVKKFLDQDLTGEALEEFRSEVRIMKKLRHPNIVLFMGAVTRPPNLSIVTEFLPRGSLYRLIHRPNNQLDERRRLRMALDAARGMNYLHSCNPMIVHRDLKSPNLLVDKNWVVKVCDFGLSRMKHSTYLSSKSTAGTAEWMAPEVLRNEPADEKCDVYSYGVILWELFTLQQPWGKMNPMQVVGAVGFQHRRLDIPDFVDPAIADLISKCWQTDSKLRPSFAEIMASLKRLQKPVTGSNIPRPVPSSSSLPTEHEQKD
What is the function of this protein?
Acts as negative regulator of salt tolerance (PubMed:18299802).  Mediates sugar response during early seedling development (PubMed:24320620).
What are the official names of this protein?
Probable serine/threonine-protein kinase SIS8, MAPKK kinase SIS8, Protein SUGAR INSENSITIVE 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with UGT72E1 in the nucleus.
Protein: CYB6_NEOYE
Sequence: MSKIYDWFEERLEIQAIADDISSKYVPPHVNIFYCLGGIVFVSFLIQVATGFAMTFYYRPTVAEAFTSVEYIMTDVNFGWLIRSIHRWSVSMMVLMMILHVFRVYLTGGFKKPRELTWVTGVILGVLTVSFGVTGYSLPWDQIGYWAVKIVTGVPDAVPVVGASIVELLRGGVSVGQGTLTRFYSLHTFVLPLLTAVFMLMHFLMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GRPE_AFIC5
Sequence: MTDNDGQKDFSEAAAENAGSKPGEPRVSKPYIMPDDPEETPSEALVKEAAEAKDRMLRTLAEMENLRKRTQREVADARAYGIAGFARDVLEIADNLQRALDAVPAEARAAADPGLTALIEGVELTERSLHRALEKNGVKKLDAAGEKFDPNIHQAMFEVPDNSVPPGTVVQVIQTGYMIGDRVLRPALVGVSKAEPKPAA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_MYCSJ
Sequence: MTVTPSGSNGAGSAAPEGRKLLRLEVRNAQTPIERKPPWIKTRARMGPEYKELKSLVKREGLHTVCEEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQIDTGKPSELDRDEPRRVAESVQAMGLRYSTVTGVARDDLPDGGAWLYAETVREIKRLNPNTGVELLIPDFNGDPALLAQVFESRPEVLAHNVETVPRIFKRIRPAFRYERSLAVLTAARDDNLVTKSNLILGMGETPDEVRTALVDLHEAGCDIITITQYLRPSPRHHPVERWVKPEEFVEFAQFAEGLGFAGVLSGPLVRSSYRAGRLYAQAARLKPAATPPVS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_NOCSJ
Sequence: MTFAASVVRTAEGDGFTPPGPHDFDLPAIGGGHDTFEMFGQSFVLGVTKPMLQLVLAAIVLFVFFFAAARKRAMVPSRLQFVGEGFYGFVRNSLGRDIIGHDFAKFVPYLFTLFFFILLNNAFGSIPFIEFPTFSRSGMVYGLAVLSWVIYNAAGISKHGFVGYLKLQTVPGGIRGPILALLIPLEFMSNILVRPVTLALRLFANMFAGHLLLILFALGGEYILTEMSVQYAPVGILAWLMFVAVAFLEMLIQFLQAYVFVLLNAMYISGAVADEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPB_IPOOB
Sequence: MRINPTTSGSEVSAVEKKNLGRIVKIIGPVLDVAFPPGKMPNIYNALVVQGRDNEQTNVTCEVQQLLGNNRVRAVAMSDTDGLMRGMEVIDTRAPISVPVGGSTLGRIFNVLGQPVDNLGPVDTNTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYLEMKESGVINEENIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAMNLKT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RS6_RHOPS
Sequence: MPLYEHVFLARQDASTQQVEELTTQITGVIEGLGGKVTKTEAWGLRSLTYRMNKNRKAHFVMLNIDGPSAVVAEVERQERINEDIIRYLTVRVEEHEEGPSAMMRKADRDRERDDRGGREGGGFRGDREGRGDREGGGFRGDRGPRRPREDADTAAASEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: K2C75_BOVIN
Sequence: MSRQSTITFQTSSRRGFSTASATTPATSRSRFSSASVTHSPAGSGGLGRISGFGSRSLYNLGGTKRVSISGCGSNFRSGFGGRASSGFGVSGGFGYGGGIGGGHGGCGFSVCPPGGIQEVTVNQSLLTPLNLQIDPNIQRVRKEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWSLLQEQGTRTVRQSLEPFFEAYITDLRRQLDSITTERGRLDAELRTMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYLNKVDLEAKANSLTDEINFLQMLFEAELCQMQTRVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEEIANRSRAEAESWYQTKYEELQVTAGQHGDDLRNTKQEISETNRMIQRLRAEIDNVKKQCASLQTAIADAEQRGELALKDARAKLVDLEEALQKSKQDMARLLREYQELMNIKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTVSSGYGGGSSIGSGSLGLSGGSGCSFMTSGGHSLGGSSFSNSSSRGLGGSGSSFKFVSTTSSSRKSYKH
What is the function of this protein?
Plays a central role in hair and nail formation.  Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity).
What are the official names of this protein?
Keratin, type II cytoskeletal 75, Cytokeratin-75, CK-75, Keratin-6 hair follicle, Keratin-75, K75, Type II keratin-K6hf, Type-II keratin Kb18.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: BUB1B_HUMAN
Sequence: MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQRVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEETMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSHLNKALWKVGKLTSPGALLFQ
What is the function of this protein?
Essential component of the mitotic checkpoint.  Required for normal mitosis progression.  The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle.  One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity.  The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE.  Required for kinetochore localization of CENPE.  Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification.  Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest.  May play a role for tumor suppression.
What are the official names of this protein?
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, MAD3/BUB1-related protein kinase, hBUBR1, Mitotic checkpoint kinase MAD3L, Protein SSK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1.
Protein: BPT_BRASB
Sequence: MTQHSRDTPQFYLTAPSPCPYLPGRQERKVFTHLVGDKATDLNDLLTHGGFRRSQSIAYRPACDQCRACVSVRVIANEFRPSRNFRKVLARNSDLVGEQRSAVPTSEQYSIFRSYLDQRHRHGGMADMTVLDYAMMVEDSHVETRIIEYRRRNLSNGPNARGGELIAVALTDVLSDGLSMVYSFFDPSETTRSLGTFMILDHIARARRQGLPYVYLGYWIEGSKKMDYKSRYLPQQRLAAAGWLRVDDEGHTAPEPQE
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_BACAC
Sequence: MKVRPSVKPICEKCKVIRRRGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: MTNK_BACVZ
Sequence: MSATKTSLYEQLTESSAAALAVKLGLFQSKSTLTCREIGDGNLNYVFHVYDKENKKGLIIKQAIPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPAVYYSDTEMAVTVMEDLSHLRISRKGLLEGQHYPNLSAHIGEFLGKTLFYSSDYALDAKVKQQLAKQFTNPELCNITERLVFTEPFLDHETNDFEEELRPYAEKVWNNSRLKEGADELKAIFLNSAETLVHGDLHTGSIFADEHETKVIDPEFAFFGPIGFDIGQFIANLLLNALSRDGDDRQPLYDHTAAVWDTFVKTFSEAWEKDCLPSRRHLLEDTLKNAFEEAVGFAGCELIRRTIGLAHVADLDEITPFDKRIERKKLALDIGAYYIENRKELKHITEVLDQFKLRVKE
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
What are the official names of this protein?
Methylthioribose kinase, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: RSMA_HAES1
Sequence: MKSKTHLGHTARKRFGQNFLHDNNIIQNIVMAIYPQKEQFLVEIGPGLGALTEPVAEKVERLTVIELDRDLAERLRHHPFLHQKLNVIEYDAMQFNFEQLYIDENLAEKNQKLRVFGNLPYNISTPLMFHLFKYHAIIQDMHFMLQKEVVKRLCAAPNSKAYGRLTIMAQYFCQVLPVLEVPPTAFKPAPKVESAVVRLIPHKELPYPVKDLYWLNRVTTQAFNQRRKTLRNALSTLFSAEKLTALAIDLEARAENLSIADYARLANYLADNPPTEDLQSE
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDH1_LACPL
Sequence: MSSMPNHQKVVLVGDGAVGSSYAFAMAQQGIAEEFVIVDVVKDRTKGDALDLEDAQAFTAPKKIYSGEYSDCKDADLVVITAGAPQKPGESRLDLVNKNLNILSSIVKPVVDSGFDGIFLVAANPVDILTYATWKFSGFPKDRVIGSGTSLDSSRLRVALGKQFNVDPRSVDAYIMGEHGDSEFAAYSTATIGTRPVRDVAKEQGVSDEDLAKLEDGVRNKAYDIINLKGATFYGIGTALMRISKAILRDENAVLPVGAYMDGQYGLNDIYIGTPAVIGGTGLKQIIESPLSADELKKMQDSAATLKKVLNDGLAELENK
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase 1, L-LDH 1.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_VIBVY
Sequence: MAAKETKELPPFEYPQGYHCIAGVDEVGRGPLVGDVVTAAVILDPNNPIEGLNDSKKLSEKKRLALLPEIQEKALAWAVGRCSPEEIDQLNILQATMVAMQRAVEGLAVKPDLVLIDGNRCPALPMDSQAVVKGDLRVAQISAASIIAKVVRDQEMEELDKQYPQFGFAQHKGYPTKAHFDAIEKHGVIEQHRKSFKPVKKALGIEE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRI_NEIG2
Sequence: MEAQKLSVEAIEKGTVIDHIPAGRGLTILRQFKLLHYGNAVTVGFNLPSKTQGSKDIIKIKGVCLDDKAADRLALFAPEAVVNTIDNFKVVQKRHLTLPDEIAEVFRCPNPNCAGHGEPVKSRFYVKKHNGQTRLKCHYCEKTYNRDSVAEA
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.