PharMolix/UniProtQA huggingface dataset:
Protein: PANB_BORPD
Sequence: MSAQQSQSRKTTTAIRQAKGPGKVVALTAYTAPMARQLDPHADLLLVGDSLGMVVYGLPSTLGVTLDMMIAHGAAVVRGSTQACVVVDLPFGSYQASPMQAFESAARVLAETGAQAVKLEGGVEMAETVQFLTARGVPVVSHIGLMPQQVNTVGGYKAQGMQADGSERILRDAQALQEAGAFALVVECTAEAVGRRVTEALQIPVIGIGASPACDGQILVTEDMLGMSGARVPRFVKQYAQLGDEIGRAAQRYAQDVRAGAFPAPEHCFGVQAKA
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_ECO57
Sequence: MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKAELESAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDATRLLRTQTSGVQIRTMKAQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAP3_MACFA
Sequence: MQSLMQAPVLIALGLLFAAPAQAHLKKLGSFSWDNCDEGKDPAVIRSLTLEPDPILIPGNVTVSVVGSTSVLLSSPLKVELVLEKEVAGLWIKIPCTDYIGSCTFEDFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPHLELPSWLTTGNYRIESILSNRGKRLGCIKIAASLKGV
What is the function of this protein?
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity).  Binds gangliosides and stimulates ganglioside GM2 degradation.  It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A.  It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity).  Has cholesterol transfer activity (By similarity).
What are the official names of this protein?
Ganglioside GM2 activator, Cerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3.
What are the subcellular locations of this protein?
Lysosome.
Protein: FNR_AGGAC
Sequence: MKILATETKLGRRVQSGGCAIHCQNCSISQLCIPFTLNQHELDQLDNIIERKKPIQKSQVLFKAGDELTSLYAIRSGTIKSYTISETGEEQITSFHLPGDLVGFDAIMNMQHPSFAQALETAMVCEIPFDILDDLSGKMPKLRQQIMRLMSNEIKSDQEMILLLSKMNAEERLAAFIYNLSQRYSARGFSAREFRLTMTRGDIGNYLGLTVETISRLLGRFQKLGVLSVQGKYITINNMAELIELSGTNKNKIQLII
What is the function of this protein?
It is involved in the activation of genes necessary for anaerobic respiration.  It probably also activates genes involved in the production of virulence factors.
What are the official names of this protein?
Anaerobic regulatory protein.
Protein: CFIS1_ARATH
Sequence: MGEEARALDMEEISDNTTRRNDVVHDLMVDLYPLSSYYFGSKEALRVKDEIISDRVIRLKSNYAAHGLRTCVEAVLLVELFKHPHVLLLQYRNSIFKLPGGRLRPGESDIEGLKRKLASKLSVNENVGVSGYEVGECIGMWWRPNFETLMYPFLPPNIKHPKECTKLFLVRLPVHQQFVVPKNFKLLAVPLCQLHENEKTYGPIMSQIPKLLSKFSFNMMEI
What is the function of this protein?
Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing.  Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition.  NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates.  The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA.  Binds to, but does not hydrolyze mono- and di-adenosine nucleotides.  May have a role in mRNA export.
What are the official names of this protein?
Pre-mRNA cleavage factor Im 25 kDa subunit 1, Cleavage and polyadenylation specificity factor 25 kDa subunit, AtCFI-25, CFIm-25, CPSF 25 kDa subunit, Cleavage and polyadenylation specificity factor subunit 25.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. CPSF5 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
Protein: IRF3_CHICK
Sequence: MAALDSEGDAQKLRFGPWLLNAVSSGLYRGLCWIDPDRRIFRIPWKHNARKDVTSSDVEIFKAWAKASGRYEGNAEDPAKWKTNFRCALRSTHMFMLLEDRSKCNDDPHKVYAVASGVPNDRGSGGPVAGALQQQPQLLLNHHDLALENTPTDSTEGVAAAALTQVDLDLLQSVLQHCNISALGSQPTLWAHTGDALPEDALLLPGQDGCLPGPQFQDWRQLEEPLLLGNQPLTGGGCGQDGAGALPVSEECAIPAPSPAEELLFQSANPAPPPPAGDIGGLPPLLDITIYYRGKMVYQEQVDDSRCVLAYQPLDPAVAEQRLVLFPSPASLPDPRQRRYTEDLLEVAGLRLEQRAGQLLATRLKKCKVFWALSQQLEGGEPPLNLLHRDQETTIFDFRVFCTELRDFRDSRRERSPDFTIFLCFGQCFSSTKPKESKLILVKLVPQFCEYWYEQVQRGGASSLNSGNVSLQLSDSFNLFELIEQYHMQTD
What is the function of this protein?
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses.  Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters.  May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family.  Binds specifically to the IFN-stimulated response element (ISRE) but not to the IRF-1 binding site PRD-I.
What are the official names of this protein?
Interferon regulatory factor 3, IRF-3.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.
Protein: SYR_BUCAI
Sequence: MNLKNTIKEDIQDALIKIAIINCDPVITLNKKTKIGHYQLNNLIKIANISNLKPFELANRIILNIKKKYMYKEITFSQPGFINFLINPYWISEQLEKIFLSPRLGINHVNAQNIVIDYSSPNIAKEMHIGHLRSTIIGDVMARILDFLGHNVIRANHIGDWGTQFGMLIAYLEVKKLVNSPLSLMKLEEYYCKAKKKYDIDQLFAEKSREYVVKLQNGDQYCYSIWKKLVSITMLENCKIYKRLHVTLKKKHTMGESIYNKMLPNIIEDLKNKKIAIEKNGSTIVFLKEFKNRLGEPMGVVIQKKDKGFLYSTTDIACLKYRYQVLHADRIIYYTDSRQHQHLLQAWTIAKKALYISQNLLLEHHIFGMMLSKDKRPFKTRDGDTIKLSALLDEATERAMRLIKNKQPNLSKKKLNQLSNIIGVGAVKYADLSKNRNTNYIFDWNEMLSFEGNTAPYIQYAYTRIVSILKKSNMPIKKLKEKIFLTKESEINLAIKILEFEEIILLISQKGTPHILCKYLYHLATSFSHFYENCSILFPKKIKTCKSRLKLSILTAKTLKKGLNMLGIRVVKKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_NEOSM
Sequence: MPVKNLKPFNASSRGAVLVDYSELWRGSPEKKLLLPKKSCSGRNNAGRITVRHRGGRGKVRYRLISFSRFSSGAPLFTKAVVERIEYDPNRTAFIALVRDFKTGLPSYIIAPEGLKKSDVLSTDVFDDMAPGACMPLGKVPLGTTVHNVELKPGAGGQLVRSAGSSARVIARDGNYTLVTLPSGEKRLILSTCHATIGAVSNADRKNTKLGKAGRSRWLGRRPSVRGVAMNPVDHPMGGGEGKTSGGRHPVSPWGFPTKGKKTRDPNKLSSKFIKSKKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: AT1B4_PIG
Sequence: MRRQLRSRRAPAFPYGYGYRLDDQDEVNQNYLADEEEEAEEARVMVVPDLEEEEKEEEEEKEEDEKEEEESHHQDTRSAWWQKLQIVNEYLWDPEKRMSLARTGQSLSLLLVIYFFFYASLAAVITLCMYTLFLTISPYVPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGDEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGIINDVINDRFVGRVIFTLNIET
What is the function of this protein?
May act as a transcriptional coregulator during muscle development through its interaction with SNW1.  Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).
What are the official names of this protein?
Protein ATP1B4, X,K-ATPase subunit beta-m, X/potassium-transporting ATPase subunit beta-m.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Single-pass type II membrane protein. Note=Detected in nuclear envelops.
Protein: TSGBD_HALVD
Sequence: MNVELQLDPRRTVPAWLAYGTPVLTVLAALAVGGVALVALNVDPVDAYGVMFVETLTSQFGLTEVLVRAVPLILAGLAVYLPLKAGLFNIGAEGQLLLGALAGTWVAVNVSLPAVALLPLMFLAACVAGAFWAGIPAWLRAKWDVNEIITSLLLTFVAQELQSYLLRGPMQGGTGNFPQSARFSDAATLPPLAGLVPGGESIPLFADVHAGLLVAVAAVVATYVVMTKTRLGFEVTFVGSNDEAARQAGMSRHTVYLFVFLLGGAFAALGGIAEIAGSQGRFRAAFAPGYGFTAIPIALLGRNSAVKVTLAGLFFAVLFVGGSSVEVAFGVPAALVEIIQALVILFLITSEFFKRYRVGIAFDRRGNDAPADATGGDARW
What is the function of this protein?
Part of an ABC transporter complex involved in glucose import (Probable).  Responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Glucose ABC transporter permease protein TsgB13.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LSRF_YERPG
Sequence: MADLDDIKDGKDFGIGIPQQNPAFTLKGSGSLDWGMQSRLARIFNPKTNRTVMLAFDHGYFQGPTTGLERIDINIAPLFEYADVLMCTRGILRSVVPAAANRPVVLRASGANSILTYLSNEAVAVAMEDAVRLNACAVAAQVYIGTEHEHQSIKNIIQLIDQGMRYGMPTMAVTGVGKDMVRDQRYFSLASRIAAEMGAQVIKTYYVDSGFERIAAGCPVPIVIAGGKKLPERDALEMCYQAIDQGASGVDMGRNIFQSDAPIAMLKAVHAIVHKNENAAAAYQLFLHEQN
What is the function of this protein?
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.  Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
What are the official names of this protein?
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG1_CANGA
Sequence: MDRFRIQDGKYVVEKEIGKGSFATVYRGHVTTDPKSHIAVKAVARSKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCERTTTDFYLVMDYCALGDLTFLIKKRKELENNHPLLQTVFNKYPPPSKEHNGLNRAFVVCYLQQLASALKFLRSKNLVHRDIKPQNLLLATPLTNYRDSKTFHELGYVGIYNLPILKIADFGFARFLPSTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLFEMCCGVPPFTASNHLELFKKIKRAHDEINFPEVCEVEDGLKELICSLLTFDPAKRIGFEEFFNNKIVTEDLSHYEVDENTELESKSKDLQESNMFVSEFLIKKRNQKGVSSRKDTEFIPKSKQEPMLDQAYKDETEMETGVKYGVNIAPEVYQNEMIDPEKLAAKLIAAKQLGSDEKLTNKNISHLLSSNSSRVNKLDKSNLSGKSDSSLDRDYVVVEKKAVEVNSLADDLAQANVGNNDEAVKDQNIKTLEQPHIQVHQPHNDIQNLQRAPSTTSGGTSSRRASLVERRLSISSLNPSNALSRALGLASTRIFGSSAQTNKNQTSNSTSPNYTQPLLNSQIFYDLTENLILHTETLNQPALINVDHAKGINEVIRILESLSAKAFVVYSYAEVKYAQIIPLPQAVIRASPALQFEKRLSDDSNPVIDEDSDEELDVQKNLSNTLLSETVNTRYRLRNDSSRNSYNKRNSFNKERFSFSSQGSNNSKRTNSYSSTLLPAEIISISKEAIVLYMKALQILAQSMKITSKWWYSCQEKICSLRLNILVQWIREKFNECLDKTDFLRMKLEEYENSKPGTHNQSPKSKISNDSNEDNVAEKVYLEKLLYDRALEISKYAANLELQGQNLHICELAYATSLWMLTISLENSPYTDQGEDEYDEFLKDTNDVLDSEDKIIIGKYIKSISHRLKMLRQKMAKY
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
What are the official names of this protein?
Serine/threonine-protein kinase ATG1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: HOOK_DROMO
Sequence: MSAQNGMYYSLLEWFKTLNLNAPHANAEELSDGVALAQALNQFAPESFTNSWLSKIKSSAVGSNWRLRMSNLKKVVEGVYEYYSDVLNYTLQPDFAKPDVQAIAEKCDLTELERLLQLVLGCAVNCAKKQSYICEIMCLEEELQANIMRALQDLESSTRQSVEGGGVVSSMSRNSLSNMLEGNTKAQEERDAMAQKCFETEKKMLLLIDEKNNLQQELQKIQQEFARLELNTIGDDGVSLGPIQAGSVRYNELRRQLELVKEELLQSEGAREDLKIKAQQQEADILHMQQRIDELMKTTAELTSLKDEVDVLRESTEKLKVCEAQLETYKKKLEEYNDLKKHVKMLEERSADYVQQNAQFEEDAKRYANTKGQIELFKKEIQDLHTKLDNESSKNVKLEFDNKNLESKALALQREKDSLLKERDNLREAFDELKCGQLSTNSGSLTGNTVSRELQPAAMVDKIQRLEAENKALREGQGGQTALAQLLDDANKRCEHLREQIKAANERILSLTHASQSDDPILKENELSKQIKQLMELNEQKTLQIEESSTQNSAMQCKITQLESTLSTREQELMAYEVKYRKCVEKAKEVIKTIDPRIASGLEANILEKSIDVIEEESKTKMSTMEEQLMTSAYYRLGVNAHRDAVESKLALLMGSGQTFLARQRQSAPRKSLTTMKSK
What is the function of this protein?
Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway.  Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton.  Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size.  Not involved in synaptic vesicle recycling.  Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs).  Has a role in regulating adult longevity.
What are the official names of this protein?
Protein hook.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Endosome. Synapse. Note=Enriched at neuromuscular synapses, in both presynaptic and postsynaptic regions.
Protein: HTPX_BURO1
Sequence: MFNWVKTAMLMAAITALFIVIGGMIGGSRGMTIALLFALGMNFFSYWFSDKMVLRMYNAQEVDENTAPQFYRMVRELATRANLPMPRVYLINEDAPNAFATGRNPEHAAVAATTGILRVLSEREMRGVMAHELAHVKHRDILISTITATMAGAISALANFAMFFGGRDENGRPANPIAGIAVALLAPIAGALIQMAISRAREFEADRGGAQISGDPQSLATALDKIHRYAAGIPFQAAEAHPATAQMMIMNPLHGGGLQNLFSTHPATEERIARLMEMARTGRFE
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
Protein: OCCT_AGRT4
Sequence: MKLKTILCAALLLVAGQAAAQEKSITIATEGGYAPWNFSGPGGKLDGFEIDLANALCEKMKAKCQIVAQNWDGIMPSLTGKKYDAIMAAMSVTPKRQEVIGFSIPYAAGINGFAVMGDSKLAEMPGLGETYSLDSQADAAKKAIADISSFLNGTTVGVQGSTTASTFLDKYFKGSVDIKEYKSVEEHNLDLTSGRLDAVLANATVLAAAIEKPEMKGAKLVGPLFSGGEFGVVAVGLRKEDTALKADFDAAIKAASEDGTIKTLSLKWFKVDVTPQ
What is the function of this protein?
Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.
What are the official names of this protein?
Octopine-binding periplasmic protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GLPK_YEAST
Sequence: MFPSLFRLVVFSKRYIFRSSQRLYTSLKQEQSRMSKIMEDLRSDYVPLIASIDVGTTSSRCILFNRWGQDVSKHQIEYSTSASKGKIGVSGLRRPSTAPARETPNAGDIKTSGKPIFSAEGYAIQETKFLKIEELDLDFHNEPTLKFPKPGWVECHPQKLLVNVVQCLASSLLSLQTINSERVANGLPPYKVICMGIANMRETTILWSRRTGKPIVNYGIVWNDTRTIKIVRDKWQNTSVDRQLQLRQKTGLPLLSTYFSCSKLRWFLDNEPLCTKAYEENDLMFGTVDTWLIYQLTKQKAFVSDVTNASRTGFMNLSTLKYDNELLEFWGIDKNLIHMPEIVSSSQYYGDFGIPDWIMEKLHDSPKTVLRDLVKRNLPIQGCLGDQSASMVGQLAYKPGAAKCTYGTGCFLLYNTGTKKLISQHGALTTLAFWFPHLQEYGGQKPELSKPHFALEGSVAVAGAVVQWLRDNLRLIDKSEDVGPIASTVPDSGGVVFVPAFSGLFAPYWDPDARATIMGMSQFTTASHIARAAVEGVCFQARAILKAMSSDAFGEGSKDRDFLEEISDVTYEKSPLSVLAVDGGMSRSNEVMQIQADILGPCVKVRRSPTAECTALGAAIAANMAFKDVNERPLWKDLHDVKKWVFYNGMEKNEQISPEAHPNLKIFRSESDDAERRKHWKYWEVAVERSKGWLKDIEGEHEQVLENFQ
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, GK, Glycerokinase, ATP:glycerol 3-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: PHYDA_ECO7I
Sequence: MRVLIKNGTVVNADGQAKQDLLIESGIVRQLGNNISPQLPYEEIDATGCYVFPGGVDVHTHFNIDVGIARSCDDFFTGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTYQYKLNDDEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLYIVHLSNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWCGISDGAIDVVATDHCTFSMAQRLQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRISPERFVELTSAMPARLFGLWPQKGLLAPGSDGDVVIIDPRQSQQIQHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL
What is the function of this protein?
Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position.  Has no activity on dihydropyrimidines.  The physiological function is unknown.
What are the official names of this protein?
D-phenylhydantoinase, Hydantoin-utilizing enzyme HyuA.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Protein: LIPQ_MYCTU
Sequence: MHIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGSPCAIGWVAGWLSAEFPARVVTGHALSRISPRSIGRFGTSWAAQRADQILHAALVDAFGPDFRDLVWHPTGEQSEAARRSGLLNLPHIPGPHRRYAAQTSDIPYGPGGRENLLDIWRRPDLAPGRRAPVLIQVPGGAWTINGKRPQAYPLMSRMVELGWICVSINYSKSPRCTWPAHIVDVKRAIAWVRENIADYGGDPDFITITGGSAGAHLAALAALSANDPALQPGFESADTAVQAAAPYYGVYDLTNAENMHEMMMPFLEHFVMRSRYVDNPGLFKAASPISYVHSEAPPFFVLHGEKDPMVPSAQSRAFSAALRDAGAATVSYAELPNAHHAFDLAATVRSRMVAEAVSDFLGVIYGRRMGARKGSLALSSPPAS
What is the function of this protein?
Shows lipase activity (PubMed:26398213).  Is highly immunogenic and may play an important role in the virulence and pathogenesis of M. tuberculosis infection, by altering the balance of cytokines.  Significantly down-regulates the expression level of pro-inflammatory cytokines (TNF-alpha and IFN-gamma) and up-regulates the level of anti-inflammatory cytokines such as IL-4 and IL-10 as compared to LPS stimulated macrophages.  Also inhibits the expression of iNOS, TLR2 and transcription factor NF-kappa-B in LPS stimulated macrophages whereas the expression of TLR-4 remains unchanged (PubMed:28412202).
What are the official names of this protein?
Esterase LipQ.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
Protein: ANGT_CRIGE
Sequence: APGDRIYVHPF
What are the official names of this protein?
Crinia-angiotensin-2, Crinia-angiotensin II.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2415_PELPB
Sequence: MIELREKNGSAVFVVKAQPRSSKSRVCGLYNGGLKVNLKAAPVDDAANRECCELFSKLFRIPPSRVHILSGQSSRTKTVMVEGISSKAAALVLEPFG
What are the official names of this protein?
UPF0235 protein Ppha_2415.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: EXPA6_ARATH
Sequence: MAMLGLVLSVLTTILALSEARIPGVYNGGGWETAHATFYGGSDASGTMGGACGYGNLYSQGYGVNTAALSTALFNNGFSCGACFELKCASDPKWCHSGSPSIFITATNFCPPNFAQPSDNGGWCNPPRPHFDLAMPMFLKIAEYRAGIVPVSFRRVPCRKRGGIRFTINGFRYFNLVLVTNVAGAGNIVRLGVKGTHTSWMTMSRNWGQNWQSNSVLVGQSLSFRVTSSDRRSSTSWNIAPANWKFGQTFMGKNFRV
What is the function of this protein?
Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans.  No enzymatic activity has been found (By similarity).
What are the official names of this protein?
Expansin-A6, AtEXPA6, Alpha-expansin-6, At-EXP6, AtEx6, Ath-ExpAlpha-1.8.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin A subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.
Protein: NUOK_XANOP
Sequence: MGHLLGLGAVLFCISLAGIFLNRKNVIVLLMSIELMLLSVNVNFIAFSRELGDTAGQLFVFFILTVAAAEAAIGLAILVTLFRTRRTINVAEVDTLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TMCB_DICDI
Sequence: MSSTKSGSSKYSSGSSISLIMGFSRSLEKGSFGVLYAMIKGNTFPRILTILSMLIEFCQLSSFGFKHQYPWGGDAGYYLKRIMSPVSHPSDVFGYLGFTILFWIAVGLLILGFLNIWYVAYQFYRGKIANIWIIRTLRWFVSFSVAVLFIPIISLLLIGLDCEGSSEGTILRKFDNETIQCFRGANLPIAVISIILIVVFSIVAFTSSATYYEYDTNVKSRFSKPHARFDVTVLFAKFVFAFFNSLVDFVPWLTSITFFVFMVILTFGSIIVLPYNNQRLNQVRSGFYTVVLWVSFMTLVTMGINDETSPATCYITIVGVFFAFPIGFFSNMFYFKWLSSKVSDIQILNQSPSMDLKDANKKGKRNSVEKESSPTSKVTWGKQPITLGSKRQIIFPFFKKKFVMSFFVEIMARSILNNNNEGVSSSSNESIERANNLYQCGLQYFPNSDLLWMAYCNFLFTVRKDRHIGYAALEKLRRMKPSFDVRFFIYQRDKEREQIMDSDLRGPEHTGKIQDFVSYMEFKKLYYGAKRHHVKCLNYIKRFWGHLLHETVDLHRLSDLSGRIATTENKANESYERLLALNPNSVRVLRDYSQFLEEVVKDKESSYKLQKKAEAIEDIMSKSQTTDFKISDIKAIDSDEDDIEKTLQEPTAIQLAKIDADIEKSGSKSGSSKSKDDSSESSSSSKGRRGKYKEFQQSNAINKLSWLMIGTTCCCIIFLIVVLVVFRGLEVKHTNAYQGIISITDCANEAVQMGMHLNAMQAYALVAGVGNNTVEASLIEIARRRALVKRGIIIMKNIHDAIYWGEGNPVSYVGDNLSQLKARDGYDIFDIGSVIFTFDQFNRSSTLLDNKQMIELYSQPSVNMSVLVAPPGSNTTSLYTQTYNAWKAGNAFIESAMLASDVTFDELRYSVNQNPNFKFVTINAPVIMPDIYNKVQTAYIDSLVSDITGTLDAILYTWCGIFAVLFLICAVLFRPIVRKISREKIRTLVLFSLAPKDVVVKLSTKKIKMVSLDSGSERDNLFDTTDDDGRDDHLGEDDNNIQTPVGDNNNNNNNNNNNNNNNGSISSNVTKSDGEIGSDGVRSSSGSNVLNTSSPYRDRRPLMDSTSVLASTATLNNRNVRLQAKDEEITNGGGERKGSDATRTALSEDKKYGWDGKSKRNLNKKSLKSILGRLHWSYILATFLLFGFITMGIWVTFTVVFNNSQSGYTLGKSCSRSLNSRVINYYVAELYTYSQYVSTQNMVDAITELQSSHQSLPYLEEVRPLMEGSYGCWALNKSTCLPPSSMYYEEVNSGLDRVVDSLAKKAINLAYTDQAALLDSPDLQWFLALIDYIFIGLDTATFTYFDYFLEKQEWANTVLTAILSVSCVILLVVHVVLFRPFMNHLRIQHIHTLALLRLAPDDIRYMEVSDKVIDED
What is the function of this protein?
Regulator of the cAMP signaling pathway specific to sexual development.  Controls the levels of external cAMP by regulating the expression of phosphodiesterase pdsA and its inhibitor pdiA.
What are the official names of this protein?
Tiny macrocysts protein B, Gamete enriched gene 04 protein, cAMP pathway regulator tmcB.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL2_CHLPD
Sequence: MAIRKLAPVTPGSRFMSYPGFDEITKSEPEKSLLVPVKRTGGRNRAGRITSRHMGGGHKRHYRIIDFKRNKDGVPATVASIEYDPNRSSRIALLHYNDGEKRYILAPKGLKVGEKVESGEKVEIKTGNTMPLKNIPLGTDIHNVEMRAGKGGQIVRSAGAFAVLAAREGDYVTLKLPSGEIRKVRVECRATIGVVGNAEHENIVLGKAGRSRWLGIRPQTRGMAMNPVDHPMGGGEGKSKSGGGRRHPKSPWGQLAKGLKTRNKKKASQKLIVRGRNAK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.