PharMolix/UniProtQA huggingface dataset:
Protein: SYI_MESH7
Sequence: MDKNFYKNSLNIFNSNFSMKANLSEKDKFYADFWEKNQIYQQILRKRRGNPRFILHDGPPYANGDIHIGHALNKILKDIIVRYKTMAGFYSPFVPGWDTHGLPIENKIINQIGSKSTLEIRRKSNDFANSQILAQMAQFKKLNLLTDFKQIYQTNTPNYEAKQLKLFKKMVSRGLVYRALKPVYWSPSSQSALAEAEIEYLEYRSPSLFTSFDIKKGNNFVAENDKLIIWTTTPWTLIANSGVAVGENFDYVRIKNEENFYVLAANLLEKLAAIFDWKHYEIIDNFPGKSILGIKYLHPIFEKICPIVSGNHVSLDVGSGLVHLAPLFGEDDYWIGRENNLEMVMHVNDDGKFNENAGQFSGQFYANSNKLITEFLEKKSKILHLSFIDHSFPHDWRTLKPVIYRGTPQWFVSIEKIKKDLEKAIEEIEFPENWLKKRLTKMVVERKDWLISRQRSWGIPLIIFYDQNKEPVLDKPEIFDYIISLVEKFGSRIWYEKTTDELLPEKYQNLGWTKENDILDVWFDSGVSFFAANISDEKPPFDIYFEGSDQYRGWFNSSLINSVIYFGFSPYKKLLSHGFVVDAKGNKMSKSRGNGVDPLVILSKYGCDIFRLWVANSEYYNDIVYSEAIFEQNVEIYRKIRNTVRFLITNLADFKPKKYELTEVDLYIFNKIQKLKNEIIQNYDQNRFVRVVKIINNFIIEFSNFYLSIVKDILYADKKESLKRRQVQYNLYELLQVLNIAIAPIMPTTAEEIYSFIQKNNKQISVHMEEFFKESHFDEELVAKWDEFFQIKDSVYQLIEQKIKSKEIKRPNEVGVLLKTDSDFIKSIDLEKLLMVAKVEFSNEKTEILQLNWEKCPRCWNHFEKINKVCARCFEVLSEIVPEKNS
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYRK2_MOUSE
Sequence: MLTRKPSAAAPAAYPTGRGGDTAVRQLQASPGIGAGAPRSGVGTGPPSPIALPPLRASNATTTAHTIGGSKHTMNDHLHLNSHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPGVPERQLESIHRRQGSSTSLKSMEGMGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTAVKRVTESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
What is the function of this protein?
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth.  Functions in part via its role in ubiquitin-dependent proteasomal protein degradation.  Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage.  Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity.  Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B.  Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B.  May play a general role in the priming of GSK3 substrates.  Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis.  Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1.  Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex.  Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity.  Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation.  Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling.  Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1.  Can phosphorylate histone H1, histone H3 and histone H2B (in vitro).  Can phosphorylate CARHSP1 (in vitro) (By similarity).  Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX.
What are the official names of this protein?
Dual specificity tyrosine-phosphorylation-regulated kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
Protein: ADRM1_XENTR
Sequence: MSSGALFPSLVPGSRGSSSKYLVEFRAGKMSLKGSTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGSVEDDLIIFPDDCEFKRVSQCTTGRVYVLKFKAGSKRLFFWMQEPKTDKDEEYCRKVNEYLNNPPMPGALGGSGSGGHELSALGGEGGLQSLLGNMSHNQLMQLIGPTGLGGLGGLGALTGPGLASLLGSGGPTTSSSSSSSRSQSAAVTPSSTTSSTRTTSAPAAPAAAPATTPSPAVSSNDGASAATSPTQPIQLSDLQNILATMNVPATGEGGQQVDLASVLTPEIMAPILANAEVQERLMPYLPSGESLPQTADEIQNTLTSPQFQQALSMFSAALASGQLGPLMSQFGLPADAVDAANKGDIEAFAKAMQTTSSQKERESSEKKEEEEDMSLD
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.  Within the complex, functions as a proteasomal ubiquitin receptor.
What are the official names of this protein?
Proteasomal ubiquitin receptor ADRM1.
What is the protein family that this protein belongs to?
Belongs to the ADRM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MUTS_PSYCK
Sequence: MPVKPSAQNNSPSKPTSKSVPVDSDSLVIGDAIYHLADHTPMMVQYLNMKVNYPQALLLYRMGDFYELFFEDAKRAAQILDITLTRRGTDKAGNTIAMAGVPFHAADSYMARLIAAGQTVVVCEQIDESATGTDNANNPSNAPTMGDKQKKDKSKSTAGTIMRREVVKTLTAGTITDDALIAPNHTPTVVAIDIETPKSNSKQPVQAAVSQMDLAAGTLTTQTISANQDDIESLQTQMLTVLARFAPSECIISEALSDSNGDISEEWLLWLRQHLNCPIIEVAANDFHREHASATLCQQFEVQRLDGLGISGAPLAQSSCAALIHYARQTQQRHVPQLNQLIVEYNDDYLIIDANSQQNLELFTPVSSNGTSLISVLNHCQTPMGRRLLVQQMKRPLRQHSRINLRLDAITSLLDTDKQSEQCSGNISLVTSLRETLNAIGDIERISSRIGLMSAKPRDLRKLADGIASSAQLTTLLTNAGISHEQAGLLPMLMQQLPAQLPAVQSVAELIERAIIVEPPAHIRDGGMLAAGYDAEFDRLTHLHDNIQVTLDEMVERARQESQLPSLKVGFNKVSGFYFELPKMQAKNAPAHFIRRQTLKSSERFITNELKTVETEYLSAQSLALTREKQLYNELLIRLGSHLAELQQLSAAIAQIDVLNNWAQLAITYNWQRPVMSNESKKSSILDNSLENSHSENGLNNNSQTSINIKEGRHVVVEAVLNPIHTHQNNPAKHSSHFVANDCVLGSYENPERLLMITGPNMGGKSTYMRQTALIVLLAHCGSFVPAARAHIGDIDRIFTRIGSADDLAGGKSTFMVEMIETANILNQATNKSLVLMDEVGRGTATTDGLAIAHACVNRLVEIGCLTLFATHYFELTKLAQNPKESSGSNDKFIRNVHVAASEIDGQLLLLHQIKDGAASSSFGLHVAKMAGIPIQVLNDAKRYLVDNLSIDNLKPDNESIDDDKNELAKSVKDKRQQTYDSNIEKSNIRNLDKKQKNIDIPQQNQLFSLQDELQAIDPDSLTPKQAHDLLYHLKEIISY
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: LEXA_ECO5E
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVDLRQQSFTIEGLAVGVIRNGDWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: UXAC_YERPB
Sequence: MSQFLTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPEQIAENYRFKNMYDIWLKGDHYKWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPATSEEIWQRGNELLAQDPFSARGIMQQMNVKMVGTTDDPIDDLRHHKAIAADGSFNIKVLPSWRPDKAFNIEAAGFNDYMQRLEAAADTSISRFADLCVALNKRMDHFAAHGCKVSDHALDVVVYGEADETTLDAILARRLAGNQPSTEEIAQFKTAVLLFLSGEYHRREWVQQYHIGALRNNNSRMFNLVGPDIGFDSINDQPLAQPLSRLLDAQGLRNALPKTILYCLNPRDNEVIGTMVGNFQGEGEAGKMQFGSGWWFNDQKDGMQRQMTQLAQLGLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVADGEAPADIALLGAMVKNICFDNAQQYFAIEL
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: SYFA_PHEZH
Sequence: MTDLTQLQAGLIGRIEAAADVAALEAIRVEALGKSGSISEMLKGLGKMSPDERREQGPKINGLRDAVATAIAEKKAALEAAELDRKLAAERVDLTLPPPPERRGRVHPTMQVLDEMIAVFAEMGFGLAEGPDIEDDFHNFTALNFPPKHPAREMHDTFWLPQNEAGERKLLRTHTSPVQVRVMRGTNEKLPAWIANGQAPPIRVIVPGRVYRSDSDATHTPMFHQLEGLVIDRNIHMGHLKWTLETFTRRFFEAEGVVTRFRPHHFPFTEPSCEMDVQCDRSGGSVKIGQGSDWLEILGGGMVHPNVLRNCGLDPDEWQGFAFGLGVDRLGMLKYGMPDLRDMFGSDVRWLEHWGFSAFQAPNPATGLS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGGU_SALNS
Sequence: MSAVTRCEDGLVLRLYIQPKASRDSIVGLHGDEVKVAITAPPVDGQANSHLIKFLGKQFRVAKSQIVIEKGELGRHKQVKIIHPQQIPPEIAALTE
What are the official names of this protein?
UPF0235 protein YggU.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: RS16_RUBXD
Sequence: MAVKIRLARHGAKGKPFYRIVVADARSPRDGKFIDRVGTYDPRKEPSEIKVDAEKAREWLRKGAQPTDQVRNLLRISGVLEEQKG
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: HEMN_MANHA
Sequence: MSEIIWDLALIQKYNHSGPRYTSYPTALEFNENYTNEDFIRAAARYPERPLSLYVHIPFCHKLCYFCGCNKVITRHRHKVEIYLDYLEREIKTRAPLFQNRLVTQIHWGRGTPTYLDEDQSARLMQMLRANFDVSDDAEISIEMDP
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
What are the official names of this protein?
Oxygen-independent coproporphyrinogen III oxidase, CPO, Coproporphyrinogen III dehydrogenase, CPDH.
What is the protein family that this protein belongs to?
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCHE_CERS4
Sequence: MRIVFVHPNYHSGGAEIAGSWPPAWVAYLCGALKKAGYTDYHFIDAMTDYVSHEKLAEKLRELQPDIVATTAITPSIYVAEETLKVAMEVVPNALRVLGGIHATFMFRQVLEEAPWIDVIVRGEGEEVLVNLVKAYEADNFAETRRQVKGLAFLDGDEIVSTAAAPTIRDVDSIDPDWGIINWKNYIYEPLGVRVAIPNMARGCPFTCSFCSQWKFWRDYRVRDPKKVVDEIEKLVNEHGVGFFILADEEPTINRKKFIEFCEEMIARGLPDKVKWGINTRVTDVKRDKELLKFYRKAGLVHISLGTEAAAQLKLDVFNKETTVAENKEAIRLLREADIFTEAQFIVGLDNETKETLEETYRMAWDWQPDLANWSMYTPWPFTPLFQELRDQVEVFDYSKYNFVTPIMKPKALTRGELLDGVMNNYRRFYMKKALFHYPWRGTGFRRRYLLGCLKAFLKAGVGRTFYDLGKAGYWGPQSKDKVDFHFDETRKIGNAQMADWEASADRAAKAAERREALRVQGKARAEERNAAKAEAAPILTAGGGGCGGHADGSDCGCGGKKQQQVDEFHVPMACGGGRQQMAEDEFAMPMACGGGKQQMEEAEERLVRPAE
What is the function of this protein?
Involved in the tetrapyrrole biosynthetic pathways leading to chlorophyll and bacteriochlorophyll (BChl).  Catalyzes the anaerobic formation of the isocyclic ring (E-ring) in Mg-protoporphyrin monomethyl ester (MPE) to yield protochlorophyllide a (PChlide a) via a six-electron oxidation and the formation of an oxo group at position C13 using oxygen from a water molecule.
What are the official names of this protein?
Anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase, MPE cyclase.
What is the protein family that this protein belongs to?
Belongs to the BchE family.
Protein: RL13_BURO0
Sequence: MKTFSAKAHEVTREWYVIDATDKVLGRVASEVARRLRGKHKPEFTPHVDTGDFIIIINASKLKVTGNKTLDKKYYRHSGYPGGIYETTFGKMQERFPGRALEKAVKGMLPKGPLGYAMIKKLKVYAEATHPHSAQQPKALEI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: 4HYPE_BRUSI
Sequence: MARHSFFCVDGHTCGNPVRLVAGGGPNLNGSTMMEKRAHFLAEYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDVAVLFIETSGCLPMCGHGTIGTVTMAIEQGLVTPKTPGKLNLDTPAGLVAIEYEQDGQYVERVRLTNVPAFLYAEGLEVECPDLGPIKVDVAYGGNFYAIVEPQENYTDMDDYSALQLIAWSPVLRQRLNEKYKFQHPELPDINRLSHILWTGKPEHPQAHARNAVFYGDKAIDRSPCGTGTSARMAQLAAKGKLKPGDEFIHESIIGSLFHGRVERAAEVAGRPAIVPSIAGWARMTGYNTIFIDDRDPFAHGFSVA
What is the function of this protein?
Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4-hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases.  Strong B-cell mitogen.  Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways (By similarity).
What are the official names of this protein?
4-hydroxyproline epimerase, Hydroxyproline-2-epimerase, HyPRE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: FLAB4_PYRAB
Sequence: MHRKGAIGIGTLIVFIAMVLVAAVAAGVIIGTAGYLQQKAQATGMQTTQEVSSGIKIINIYGYVNSSVPSNGTITKMAIFVSPNAGSGGISLSNVKIVLSDGKKLVVYNYSKGLLYDKQISDLFNDSIVTIWNNITDTTFGIAVINDSGNKMDKDYPNLEWGDTVALLLRTTVFETEDNRRGIGPGTRIVGKVIPEVGAAGVIDFTTPSTYNYRVMVLQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
What are the official names of this protein?
Flagellin B4.
What is the protein family that this protein belongs to?
Belongs to the archaeal flagellin family.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: RS19_SYNJB
Sequence: MGRSLKKGPFVDAKLLLKVEKMNERNEKHLIKTWSRASTILPVMIGHTIAVHNGKQHVPIYITDQMVGHKLGEFVPTRTFRGHAGSDKKAARR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: MINE_POLSJ
Sequence: MASFLSFLLGEKKQTASVAKERLQIILAHERTGRSHKPDYLPALQRDLIAVIAKYIHINPNDIKLHLERQDNLDVLEVKIELPDAK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: Y1869_ARATH
Sequence: MPLCNNFSGNLVVAVALFFAGALYIFNYQNYVNTLRTTQYPVDELEAALYTAAAGNNKTVIITMVNKAYVKEVGRGSTMLDLFLESFWEGEGTLPLLDHLMVVAVDQTAYDRCRFKRLHCYKMETEDGVDLEGEKVFMSKDFIEMMWRRTRLILDVLRRGYNVIFTDTDVMWLRSPLSRLNMSLDMQISVDRINVGGQLINTGFYHVRSNNKTISLFQKWYDMRLNSTGMKEQDVLKNLLDSGFFNQLGLNVGFLSTTEFSGFCQDSPHMGVVTTVHANCCLHIPAKVFDLTRVLRDWKRYKASHVNSKWSPHLKCSRSWNDTHYIPRL
What are the official names of this protein?
Uncharacterized protein At1g28695.
Protein: CCME_METRJ
Sequence: MTRKKRRLILIAACGSVLALAVGLILYAMSGSIVFFRSPTDIAKQAIAPGTRLRLGGLVKDGSLRRGPDQTVDFAVTDTNETVEVHYKGLLPDLFREGQGVVAEGVLEPGGQFRADTVLAKHDESYMPREVADALKAQGRWQEGGPNRGGPAPKPATAAADSTLGPRSER
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: RUVA_MYCCT
Sequence: MNDYINGFLYKIDDKFLYLELNYLGYRYLYLKSDLKNFKLNENNKVYIAINVIDNHFKYYGFFNQLVRDLFEILININTIGEKTAFLILENYSYQELIDIFKNGKTDKILQLKGIGNYTARLIINSVQKELFNNKISEKKNKVITSLEKLGYKTKDIYKIIINVDEDLTIDELTKYVLEKLSYINN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: CSP_PLACM
Sequence: MKNFNLLAVSSILLVDLFRTHWGHNVDFSKAINLNGVSFSNVDASSLGAAQVRQSASRGRGLGENPKEEDGADKKKKKDEKQVEPKKPRENKLKQPVENADGNAGGNAGGNAGGNAGGNAGGNADGNAGGNAGGNAGGNAGGNAGGNADGNAGGNADGNAGGNADGNAGGNAGGNAGGNADGNAGGNAGGNAGGNAGGNAGGNAGGNAGGNADGNAGGNAGGNAGGNADGNAGGNAGGNAGGNAGGNAGGTAGGNADGNAGGNAGGNAGGNAGGNAGGNAGGNAGGNAGGNAGGNAGGNAGGNAGGNAGANAGNKKAGDAGAGQGQNNEAANMPNVKLVKEYLDKIRSTISTEWSPCSVTCGKGVRMRKKVSAANKKPEELDVNDLETEVCTMDKCAGIFNVVSNSLRLVILLVLALFN
What is the function of this protein?
In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
What are the official names of this protein?
Circumsporozoite protein, CS.
What is the protein family that this protein belongs to?
Belongs to the plasmodium circumsporozoite protein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm. Note=Localizes to the cytoplasm and the cell membrane in oocysts at day 6 post infection and then gradually distributes over the entire cell surface of the sporoblast and the budding sporozoites.
Protein: NDK_SACS2
Sequence: MVAQRTFVMIKPDGVKRGLIGEIISRFEKRGLKIVSLKMVKMSRDTAEKLYEEHKGKSFFEELVNYVTSGPVVCMVIEGDDVVQVIRRMIGNTDPKEAPPGTIRGDYALSKSENVIHASDSIEKAQREMSLFFDKSDL
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLSA_VIBVU
Sequence: MKPTKELLNEILHEVRPLIGRGKVANYIPALARVPAHKLAIAVYTNQGEVIKAGDADEAFSIQSISKALSLTLAMGLYQPDEIWRRVGKEPSGQAFNSLIQLEMEQGIPRNPFINAGAIVVADLLASRLSAPRQRLLEFVRQLSGETHICYDKVVAASEMMHSDRNAAIAYLMRSFGNFENEVIPVLNNYFHACALKMSCVDLAKTFSYLANKGVSVHTDQRVISPVQTKQLNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAIVPGEMTIAVWSPELDPSGNSLAGTKALELLSERIGRSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: ACCD_HYDCU
Sequence: MSWFEKILPSIKQVTERKKNVPEGLWTKCPKCESTLYRAEVRRNLEVCPKCDHHMRLGGRDRLEAFFDEGTGVEISAEVTPVDALKFKDIKPYKTRIAQAQKATGEKDSFITMTGKIQGLEVVAGAFEFKFMGGSMGSVMGEKFVRAVNEAIERRCPLIVFSASGGARMQEALFSLMQMAKTSAALGHLRANKLPFISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPEGFQRSEFLLEHGAIDRIIHRHNLSDELASICRMLLQKSA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_COXBU
Sequence: MFSPLTKQLIEALQCLPGIGPKSAQRMAFHLLAKSGQAKGLALSDALQSAIRQVGECKLCQIYTEQPLCNICNNPKRDSTLLCVVESPADVVAIEQTQIYSGRYFVLHGHLSPLDGIGPQEIGIPALLDRLRNETIKELIIATNATMEGKATAHYVANHIDHTKIKCSRIAHGVPMGGELEYLDGGTLIHALHSRIPVEDN
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RSMC_SALCH
Sequence: MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPALFECAASRAHTQQFHHWQVLSRQMGDNVRFSLVAQASDVADCDTLIYYWPKNKPEAQFQLMNILSLMPSGSDVFVVGENRSGVRSAEQMLADYAPLNKVDSARRCGLYHGRLEKQPQFSLESWWAEYNIDGLTIKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSAALASHSPKARLTLCDVSAPAVEASRATLAANGLEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPKILDETFGFHEVIAQTGRFKVYRTVMTRQAKK
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MALT_ECOLU
Sequence: MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALITSPAGYGKTTLISQWAAGKNDIGWYSLDEGDNQQERFASYLIAAVQQATNGHCAICETMAQKRQYASLTSLFAQLFIELAEWHSPLYLVIDDYHLITNPVIHESMRFFIRHQPENLTLVVLSRNLPQLGIANLRVRDQLLEIGSQQLAFTHQEAKQFFDCRLSSPIEAAESSRICDDVSGWATALQLIALSARQNTHSAHKSARRLAGINASHLSDYLVDEVLDNVDLATRHFLLKSAILRSMNDALITRVTGEENGQMRLEEIERQGLFLQRMDDTGEWFCYHPLFGNFLRQRCQWELAAELPEIHRAAAESWMAQGFPSEAIHHALAAGDALMLRDILLNHAWSLFNHSELSLLEESLKALPWDSLLENPQLVLLQAWLMQSQHRYGEVNTLLARAEHEIKDIREGTMHAEFNALRAQVAINDGNPDEAERLAKLALEELPPGWFYSRIVATSVLGEVLHCKGELTRSLALMQQTEQMARQHDVWHYALWSLIQQSEILFAQGFLQTAWETQEKAFQLINEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIEVLSSYQPQQQLQCLAMLIQCSLARGDLDNARSQLNRLENLLGNGKYHSDWISNANKVRVIYWQMTGDKAAAANWLRHTAKPEFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARSLRLMSDLNRNLLLLNQLYWQAGRKSDAQRVLLDALKLANRTGFISHFVIEGEAMAQQLRQLIQLNTLPELEQHRAQRILREINQHHRHKFAHFDENFVERLLNHPEVPELIRTSPLTQREWQVLGLIYSGYSNEQIAGELEVAATTIKTHIRNLYQKLGVAHRQAAVQHAQKLLKMMGYGV
What is the function of this protein?
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides.  Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.
What are the official names of this protein?
HTH-type transcriptional regulator MalT, ATP-dependent transcriptional activator MalT.
What is the protein family that this protein belongs to?
Belongs to the MalT family.