PharMolix/UniProtQA huggingface dataset:
Protein: CENPA_KLUMA
Sequence: MEQSVRSIDGARSVAGAGRTIIDRESINQRALQLLQRNRQRRLLLKRSEDRARYIPERREQKRELDETLETRNVPQHHISAHERITKAKSHGSKYKPSDLALAEIRKYQRSTDLLISRMPFARLVKEVTDQFASDEEPLRWQSMAIMALQEASEAYLVGLLEHTNLLALHAKRITIMRKDMQLARRIRGQFI
What is the function of this protein?
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes.  Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore.  Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
What are the official names of this protein?
Histone H3-like centromeric protein CSE4, CENP-A homolog, CENPA homolog.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.
Protein: RS9_STRGC
Sequence: MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLVINQPFAVTSTVGQYDVFVNVNGGGYGGQAGAIRHGIARALLQVDPDFRDSLKRAGLLTRDARMVERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RR7_ZAMFU
Sequence: MSRRSTAEKETAKSDPIYRNRLVNMLVNRILRHGKKSLAYRILYRAMKNIQQKTEKNPLSVLRQAIRGVTPNVTVKARRVGGSTYQVPIEIRSTQGKALAIRWSLGASRKRPPGRNMAFKLSYELMDAARENGNAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PANC_ECO8A
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIITIAGQELNEKGFRADDIQIRDADTLLEVSETSKRAVILVAAWLGDARLIDNKMVELA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_PARPJ
Sequence: MSNKKADSKPQSRYPVNLLDTPFPMRGDLPKREPQWVKEWQERKVYETIRAASKGRKKFILHDGPPYANGDIHLGHAVNKILKDMIVKARNLAGFDAVYVPGWDCHGMPIEIQIEKQFGKSLPAAEVMQKARAYATEQIEKQKVGFRRLGVLGDWDNPYKTMNFTNEAGEIRALAKIMEKGYVFRGLKPVNWCFDCGSALAEAEVEYKDKTDPTIDVLFSFAEPEKTAQAFGLSALPREEGGIVIWTTTPWTIPANQALNLHPEIVYALVDTPRGLLILAEERVEACLKLYGLEGTIVATAPGAKLVNVRFNHPLASAHPGYKRTAPVFLGDYVTTETGTGIVHSSPAYGVEDFVSCKAHGMADSDIINPVMGDGRYIESLALFGGLSIWAANPQIVEALQGAGSLMRTEKYTHSYMHCWRHKTPIIYRATSQWFAGMDVKPNDTDKTLRETALEGIENTAFYPAWGKQRLFSMIANRPDWTLSRQRQWGVPMAFFVHKETGELHPRTLELLEEVAQRVEKAGIEAWQTLDPRELLGDDANMYEKNRDTLDVWFDSGTTHWHVLRGSHKDELQFPADLYLEGSDQHRGWFHSSLLTASMLDGRPPYNALLTHGFTVDGEGRKMSKSLGNGIDPHEVANRLGAEIIRLWIASTDYSGELAISEEILKRVTEGYRRIRNTLRFLLANLSDFDFAQHARPVEDWLEIDRYAVALSTNLQNDILSHYDKYEFHPVVAKLQTFCSEDLGGFYLDVLKDRLYTTAADSVARRSAQTALYHIAHGLLRLMAPFLSFTAEEAWKIFQPNSETIFTETYHAFPAVPDAGALLDKWTLLRAARSDVTKALEEARVANLIGSSLQAEVEIRASGARYDALTSLGDDLKFVLITSAATVVKVDSEAEEAVEVIASKYLKCERCWHYRADVGANAEHPTLCDRCFSNLFGNGEIRSAA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_DELAS
Sequence: MSGFGTQIDVKALGKVAVLLGGRSAEREVSLMSGTGVLKALLSHGVDAHAFDPAERDLGELKKEGFDRCFIALHGRYGEDGTVQGALELLGIPYTGPGVMASSIAMDKIMTKRIWRFEGLPTPDWRLVASAGETRAALQALGAPMIVKPSREGSTIGLTKVWTAEECDQAYVLASRYDPEVLCEEFIEGDETTCPVLGTGEGAHALPVIRIVAPEGNYDYQNKYFTDDTKYHCPSGLPAEEEAEIRRIVVRAFRTLGCRGWSRADIMIRASDRKPFLLEINTSPGMTGHSLVPMSARAIGVSYENLCLGILASAALDAAQPEQEHA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISX_LISIN
Sequence: MKTLTGTTEAILNELRAENSSNSSDQIASEVKAIIENVKNTGDQALFDYTAKFDGVELNELRIPNSDIQIATNKVDPAFLEALKEAKANIESFHNKQKQSAFLDSEKDGVIRGQIIRPLETVGVYVPGGTAAYPSSVLMNVLPAKIAGVKRIVMITPPSENGINPHVLAAANLAGVDEIYQVGGAHGIAALAYGTASIPKVDKIVGPGNVYVATAKREVFGLVDIDMIAGPSEIVVLADETAKPAFIAADLLSQAEHDTLARAILITTSEKIAQQTKIELNKQLENLPRKAIAKEATESHGKIIITKSTAEMFHIMNEIAPEHLEVQLENPMNYLYQIKNAGSIFLGNYASEPLGDYFAGPNHVLPTSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEKDAIVLLASKEGLDAHAKAIQIRFEEEN
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: SYR_ALISL
Sequence: MNIQSLINDKVSQALEAAGAPAGSPAAVRQSAKAQFGDYQANGVMGVAKRLGTNPREFAQKVLDVLDLDGIASKTEIAGPGFINIFLSEEFLAKQAEAALADERLGVALETKQNIVADYSAPNVAKEMHVGHLRSTIIGDAVVRTLEFLGHNVTRANHIGDWGTQFGMLIANLERIQKEKGEVSMELSDLEGFYRESKKLYDEDEEFAVTARGYVVKLQGGDAFCADMWKKLVDVTMVQNQRNYDRLNVSLTRDNVMGESMYNSMLAPIVADLQEKGLAVESDGAQVVYLDEYKNKDGDPMGVIVQKRDGGFLYTTTDIACAKYRFEELNADRVLYFIDSRQHQHLMQAWTIVRKAGYVPESVSLEHHAFGMMLGKDGRPFKTRAGGTVRLADLLDEAEQRAIALIEEKNKDLSTEEKAKIATTVAMAAVKYSDLSKHRTTDYIFDWDNILAFEGNTAPYMQYAYTRVASIFSKADLSMDNLAGEVKITDEKEKALITKLMQFEEAVQAVASEGQPHLMCAYLFELAGQFSSFYEACPILNNDDESIKQSRLKLAALTAKTIKQGLDLLGIETLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERC_PSEA8
Sequence: MRADLDAFLEHLRSERQVSAHTLDGYRRDLLKILALAEKAGLSDWNALDTRSLRTFVARLHQQGQSSRSLARLLSATRGLYQYLLREGRCRHDPANGLSAPKSPRKLPRTLDADRALQLLDGAVEDDFIARRDQALLELFYSSGLRLSELVGLDLEWLDLKEGLVRVRGKGNKVRELPVGKAARQALEAWLPLRAQAAPEDGAVFIGRGGKRLTPRAIQLRVRQAGVRELGQHLHPHMLRHSFASHLLESSGDLRAVQELLGHADIATTQIYTHLDFQHLASVYDRAHPRAKRKGNADGGNDP
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_CHRSD
Sequence: MSQFTLSAEVRHDLGKGASRRLRRENKKVAAIIYGGSKTPQPITLEKSAFYKAIEDEAFFSSVINIDLEGQSEQVIIRDIQRHPYKALVTHADFMRVDATHEITMNVPLHINGEEACKGVKDEDGVLHVLANDVEISCLPGKLPEYLEVDVTNLGLGETLHLSDLPLPEGVSLVALSHGEEHDFGVVSVTRADTGTEGDEEGGEEATDEDGEKSE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RS11_FRASN
Sequence: MPPKTRAAGVKKVRRKEKKNVAHGHAHIKSTFNNTIVSITDPSGNVISWASAGHVGFKGSRKSTPFAAQMAAENAARKAQEHGMRKVDVFVKGPGSGRETAIRSLQAAGLEVGAIQDVTPTPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: EFG_WOLTR
Sequence: MEIDISKYRNIGIMAHIDAGKTTTTERILFYTGKQNRIGEVHDGAASMDWMEQEKERGITITSAATTCFWNGYRINIIDTPGHVDFTIEVERSLRVLDGAVAVFDGVAGVEPQSETVWRQADKYSVPRVCFINKMDRIGVDFYRCVNMIKSKLGVVPLVIQLPIGSEKDFKGVVDLISMKAIIWEEETLGAKFSYEDIPSDLLDKAQEYRNLLLDTAAGMDDEAMNAYFESNDLPVDLLKRCVRSGAIKGAFVPVLCGSAFKNKGVQPLLDSIVDFLPSPVDVDEVVGTDPKDLEKKIKVKPSEKEKFVALAFKVMTDKFVGSLTFIRIYSGKLKSKSTVLNAGKNETEGIGRMLLMHANNREDINEAKVGDIVALVGLKKAITGDTLCSSDFPILLERMEFPEPVIEIAVEPRTTSDQEKLGIALSRLVAEDPSLRMSVNAENGQTILKGMGELHLEIITDRVKREFNVDVNIGAPQVAYRETITKSVEIDYTHKKQSGGAGQFAKVKILFEPLEAGSGFQFESKIVGGAIPKEYIPGVQNGLELIKEGGMVSGFPVIDFKATLIDGAFHEVDSSPLAFELAAKGAFKEMASKAGPKMLEPIMKVEIITPEEYMGDIMGDVNSRRGQVLSMETHNNSTIILALVPLASMFGYINVLRSMSQGRAQYSMHFSCYEQVPQYVVNELKYN
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB144_ARATH
Sequence: MTTTTTTTMSTLPMVLVDEILSRVPITSLRSLRSTCKRWEAQSKTNLVGGKATARKSSYLGFILIGNKICSMKLDLNGGDDFVDTSVNQISAFDDFEISQLFHCDGLLLCVSNKHYYSNTVMVCNMYLGETRLIEHCCLLEGFDNFGSYAFGYDSSKNRNHKIFRKKLVSGGYEIYSFKSDSWKDLNVDLGESTELCELGSVSLKGNAYFSVITKHEEEELWENNLLCFDFTTESFGKFLSLPFDNVTAEEEFGIMVLSCVRDEHLAVLYQLDTLGIWISTEIEPNKVSWREFLQVDLYTLDGFPDAFTAGRFIVDEEKQVVVVFNEATEIDLNHGNAFIFGRDGYFTSFNVGDTPPQDFTSYVPSLASLQIEKTGG
What are the official names of this protein?
Putative F-box protein At3g13830.
Protein: HGS_HUMAN
Sequence: MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPSQDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
What is the function of this protein?
Involved in intracellular signal transduction mediated by cytokines and growth factors.  When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF.  Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin.  May concentrate ubiquitinated receptors within clathrin-coated regions.  Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex).  The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.  May contribute to the efficient recruitment of SMADs to the activin receptor complex.  Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
What are the official names of this protein?
Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Protein pp110.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein. Note=Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments.
Protein: PDXH_MYCLE
Sequence: MAGPDDQHLSGMRVEYGSVEKDGSPDLDTDWLYDGWLTLFCKWIDDAERAGVAEPNAMVLATVANGRPVSRSVLCKGADEAGIIFFTNYDSDKGDDLAATPYASVTFPWYQLGRQVHIRGPVSTVDPQVSEDYWSKRPRGSQLGAWASHQSRPIASRTALLDQLLEVTVRFADSELIPLPPNWGGYLIVPEVVEFWQGRENRVHNRIRVTGGCIERLQP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: CHEB2_CARHZ
Sequence: MSKIRVLIVDDSALMRKYLREILEQDPEIEVIAVARNGREAVEKALELSPDVITMDINMPEMDGLTAIQYIMLHRPTPIIVISSLTQKGALTTFEALELGAVDYVAKPDGTVSLKIKEVAEEILQKVKAVAKSRGVVRLKARKERPFVQEVPKTRPVSPDTSFKKLILIGVSTGGPKALMEIIPRLPGNLDASVVIIQHMPEKFTASFAARLNNYSELYVKEAEDGESLERGKVLVARGGINLKLERKLGINVVRVRYTPLPRETIYWPSVDVAFRSALTVIEPHRIIAVLLTGMGDDGAQAMVEIKQKGGYTIAESEETAVVWGMPREAIERGGASEILPVYQIADRIVELVR
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 2.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_BORPA
Sequence: MTSALHESSIKSLPLLGRGKVRDMYAVGDDKLLIVASDRISAFDVILDDPIPGKGQVLTELTDFWLRKLAHILPNHSTGIQPEDVVAPDEVDQVRGRAVVVKRLKPILVEAVARGYLIGSGWKDYQASGSVCGIALPAGLQQASQLPEPIFTPAAKAEFGMHDENVDFAHVVKEVGQEMAERIRDVTLRLYGEAARFAATKGIIIADTKFEFGLDDNGTLHLMDEVLTPDSSRFWPADGYRVGISPPSFDKQFVRDWLETQPWDKTPPAPRLPRDVLEKTAAKYREALDRLLA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: TSAD_CHLCV
Sequence: MLTLGLESSCDETACALVDAKGHIMANVVFSQQDHVAYGGIVPELASRAHLRVFPSVVDSALKESGVSLEDIDLIAVTHTPGLIGSLAIGVNFAKGLAIGCQKPIIGVNHVEAHLYAAYMEAENVEFPALGLAVSGAHTAMFLMEDPLTYKLIGKSRDDAIGETFDKVARFLGLPYPGGSLIEKLASCGCEESYSFSPSKVPGCDLSFSGLKTAVLYAIKGNNSNSRTPLPELSEAEKSDIAASFQRAAFTSIAQKLPNIVKKISCRSILVGGGVASNKYFQNLLKNTLNLPLYFPSSKLCTDNAAMIAGLGRELFLSDKSTIGIHPCARYHWESISASLSPLP
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZBT7A_CHICK
Sequence: MAGGVDGPIGIPFPDHSSDILSSLNEQRNNGLLCDVVILVEGQEFPTHRSVLAACSQYFKKLFTSGLVVDQQNVYEIDFVSADALSALLEFAYTATLTVSTSNVNDILNAAKLLEIPAVRDVCTDLLDRKILAKNDQMDLVDQIDQRNHLRAKEYLEFFQSNPVNGHQGSFPWTNPELRDLQRLNFRGQEDEEEPDCNGLDFYSQAPLNERPKANDCDPDSNPAMWLDREEEEAAAAPGSLFSPSQNGHYSGRGLGTPGEEEGAPGAALDQQDAGDSPSFVPTGAEAEDDARDVDGLAASVLQQVMGSVGRQQLGDDERKDDDGVVDYYLKYFGSSNESDVYPSWSQKVEKKIRAKAFQKCPICAKVIQGAGKLPRHIRTHTGEKPYECNICNVRFTRQDKLKVHMRKHTGEKPYLCQQCGAAFAHNYDLKNHMRVHTGLRPYQCDSCFKTFVRSDHLHRHLKKDGCNGIPSRRGRRPRVRDAGGLPTPTGNPEDGGFQGGGESQESEDTVQGNGREQHFEESSTAEAAGLNVAGGAAEGSAPGPS
What is the function of this protein?
Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation.  Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity).  May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ and in alternative splicing (By similarity).
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 7A, Leukemia/lymphoma-related factor, cLRF.
What are the subcellular locations of this protein?
Nucleus.
Protein: IBB2_ARAHY
Sequence: AASDCCSACICDRRAPPYFECTCGDTFDHCPAACNKCVCTRSIPPQCRCTDRTQGRCPLTPCA
What are the official names of this protein?
Bowman-Birk type proteinase inhibitor B-II.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: GL_HCMV4
Sequence: MCRRPDCGFSFSPGPVILLWCCLLLPIVSSAAVSVAPTAAEKVPAECPELTRRCLLGEVFQGDKYESWLRPLVNVTGRDGPLSQLIRYRPVTPEAANSVLLDEAFLDTLALLYNNPDQLRALLTLLSSDTAPRWMTVMRGYSECGDGSPAVYTCVDDLCRGYDLTRLSYGRSIFTEHVLGFELVPPSLFNVVVAIRNEATRTNRAVRLPVSTAAAPEGITLFYGLYNGVKEFCLRHQLDPPLLRHLDKYYAGLPPELKQTRVNLPAHSRYGPQAVDAR
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Acts as a functional inhibitor of gH and maintains gH in an inhibited form.  Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH (By similarity).  In human cytomegalovirus, forms two distincts complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope.  The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA.  The gH-gL-UL128-UL130-UL131A pentamer is essential for viral entry in epithelial, endothelial and myeloid cells via interaction with host NRP2 (By similarity).
What are the official names of this protein?
Envelope glycoprotein L, gL.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein L family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans- Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans- Golgi where secondary envelopment occurs.
Protein: CML2_MACMU
Sequence: MEDLEETLFEEFENYSYALDYYSLESDLEEKVQLGVVHWVSLVLYCLSFVLGIPGNAIVIWFTGFKWKKTVSTLWFLNLAIADFIFLLFLPLYISYVVMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTVIRHHVLTWVKFIVGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILAVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGTVSEQLRNSETKNLCLLETAQ
What is the function of this protein?
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (By similarity).  Signals mainly via beta-arrestin pathway.  Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too.  Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).
What are the official names of this protein?
Chemerin-like receptor 2, Chemerin chemokine-like receptor 2, Chemokine-like receptor 2, G-protein coupled receptor 1.
What is the protein family that this protein belongs to?
Belongs to the chemokine-like receptor (CMKLR) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Internalizes in presence of its ligand, TAFA1 (By similarity). Internalizes efficiently in response to RARRES2 (By similarity).
Protein: MT2_FRAAN
Sequence: MSCCGGKCGCGAGCKCGSGCNGCGNYADITEQSSASETLVMGVVGTQKLNYGQAEAGVATEGSCSGCKCVYCTCDPCTCK
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-like protein type 2 MET1.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
Protein: RL28_KLEP3
Sequence: MSRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRVSAKGMRVIDKKGIDTVLSELRARGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RRF_PSYWF
Sequence: MINDIKKDGEDRMKKTLEVLENAFSKVRTGRAHPGMLSGVMVSYYGADTPLNQVASVNVEDSRTLLVQPFERSMVQAVDKAIREADLGLNPMTADVIRVPMPALTEETRRDMQKLARGEAENSRVSIRNVRRDMLNDIKELAKEKEISEDDERRASDDIQKITDKYIASIDSKLEAKEKELMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMT1_POPTM
Sequence: MGSTGETQMTPTQVSDEEAHLFAMQLASASVLPMILKTAIELDLLEIMAKAGPGAFLSTSEIASHLPTKNPDAPVMLDRILRLLASYSILTCSLKDLPDGKVERLYGLAPVCKFLTKNEDGVSVSPLCLMNQDKVLMESWYYLKDAILDGGIPFNKAYGMTAFEYHGTDPRFNKVFNKGMSDHSTITMKKILETYKGFEGLTSLVDVGGGTGAVVNTIVSKYPSIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSVPKADAVFMKWICHDWSDAHCLKFLKNCYDALPENGKVILVECILPVAPDTSLATKGVVHVDVIMLAHNPGGKERTEKEFEGLAKGAGFQGFEVMCCAFNTHVIEFRKKA
What is the function of this protein?
Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid.  The resulting products may subsequently be converted to the corresponding alcohols that are incorporated into lignins.
What are the official names of this protein?
Caffeic acid 3-O-methyltransferase 1, CAOMT-1, COMT-1, S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.