PharMolix/UniProtQA huggingface dataset:
Protein: DGKZ_MOUSE
Sequence: MEPRDPSPEGRSSDSESASASSSGSERDAGPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESEEQIQSTVDWSESAVYGEHIWFETNVSGDFCYVGEQHCVAKMLPKSAPRKKCAACKIVVHTQCIKQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMMQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLSASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQREPDGAGAKSPMCHQLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSMQGDTALPQGEELIEAAKRNDCCKLQELHRAGGDLMHRDQKSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDLQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
What is the function of this protein?
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12883552).  Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:12883552).  Also plays an important role in the biosynthesis of complex lipids (Probable).  Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species.  Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity).  The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (PubMed:12883552).  By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity).  Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (PubMed:27739494).  Regulates RASGRP1 activity (By similarity).
What are the official names of this protein?
Diacylglycerol kinase zeta, DAG kinase zeta, Diglyceride kinase zeta, DGK-zeta.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Cell membrane. Cell projection, lamellipodium.
Protein: DHRS3_MOUSE
Sequence: MVWKWLGALVVFPLQMIYLVTKAAVGMVLPPKLRDLSRESVLITGGGRGIGRHLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQMAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHVNTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVDAVQQNQALLLLPWTMNILIILKSILPQAALEEIHRFSGTYTCMNTFKGRT
What is the function of this protein?
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
What are the official names of this protein?
Short-chain dehydrogenase/reductase 3, Retinal short-chain dehydrogenase/reductase 1, retSDR1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RSLBB_RAT
Sequence: MRLIQNMCTIAEYPAPGSTAADCCLGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYERNAGNLYTRQVHIEGETLAIQVQDTPGIQVHENGLSCNEQLNRCIRWADAVVIVFSITDHKSYELISQLHQHVQQLHPGTRLPVVVVANKADLLHVKQVDPQLGLQLASMLGCSFYEVSVSENYNDVYSAFHVLCKEVSPKQQASGTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV
What are the official names of this protein?
Ras-like protein family member 11B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
Protein: CRCB_SALHS
Sequence: MLQLLLAVFIGGGTGSVARWMLSMRFNPLHQAIPIGTLTANLLGAFIIGMGFAWFNRMTHIDPMWKVLITTGFCGGLTTFSTFSAEVVFLLQEGRFGWALLNVLINLLGSFAMTALAFWLFSAAAAR
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TAL_BURM1
Sequence: MTTALDQLKQYTTVVADTGDFQQLAQYQPQDATTNPSLILKAVQKDAYKPILEKTVRDHRNESTDFIIDRLLIAFGTEILKIIPGRVSTEVDARLSFDAKRSIDKAHELIKLYEAAGIERDRILIKLASTWEGIRAAETLQKEGIKCNMTLLFSLVQAAACAEAGAQLISPFVGRIYDWYKKQAGADWDEAKNGGANDPGVQSVRRIYTYYKTFGYKTEVMGASFRTTSQIVELAGCDLLTISPDLLQKLHDSNETVTRKLSPDALHDKPTERVAIDEASFRFQLNDEAMATEKLAEGIRVFAADAVKLEKLIEALR
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1465_STRT1
Sequence: MYSIVAEESGLLPRERLLQKGAEVLSDQELLAIVLRTGTKSESVLSMANRILKGMTSLADLSRLSLNELQEIPGIGRVKSIELKAMVELAKRIEKAELARSEQIMSSQQVARRMMLDIGDKPQEHLVAIYLDTQNRIIQQKTVFIGGVRRSIAEPREILYYACHLMATSLIVVHNHPSGEAYPSRNDIDFTQKIKRSCDDLGICLLDHLIVGKSTYYSFREEREDFEL
What are the official names of this protein?
UPF0758 protein str1465.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: CFAI_MOUSE
Sequence: MKLAHLSLFLLALHLSSSRSPSASDLPQEELVDQKCLLQKYTHRSCNKVFCQPWQRCIEGTCICKLPYQCPRAGTPVCAMNGRSYPTYCHQKSFECLHPEIKFSHNGTCAAEGKFNVSLIYGRTKTEGLVQVKLVDQDERMFICKNSWSMAEANVACVDLGFPLGVRDIQGSFNISGNLHINDTECLHVHCRGVETSLAECAFTKRRTELSNGLAGVVCYKQDADFPTSLSFQCVNGKHIPQEKACNGVNDCGDQSDELCCKGCRGNASLCKSGVCIPDQYKCNGEVDCITGEDESRCEEDRQQNIPKGLARSAQGEAEIETEETEMLTPGMDNERKRIKSLLPKLSCGVKRNTHTRRKRVIGGKPANVGDYPWQVAIKDGQRITCGGIYIGGCWILTAAHCVRPSRAHSYQVWTALLDWLKPNSQLGIQTVKRVIVHEKYNGATFQNDIALIEMKMHTGKKECELPNSVPACVPWSPYLFQPNDRCIISGWGRGKDNQKVYSLRWGEVDLIGNCSQFYPDRYYEKEMQCAGTRDGSIDACKGDSGGPLVCEDINNVTYVWGIVSWGENCGKPEFPGVYTRVANYFDWISYHVGRSLVSQHNV
What is the function of this protein?
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways.  Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins.  Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces.  The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization.
What are the official names of this protein?
Complement factor I, C3B/C4B inactivator.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: S66A2_HUMAN
Sequence: MEAEGLDWLLVPLHQLVSWGAAAAMVFGGVVPYVPQYRDIRRTQNADGFSTYVCLVLLVANILRILFWFGRRFESPLLWQSAIMILTMLLMLKLCTEVRVANELNARRRSFTAADSKDEEVKVAPRRSFLDFDPHHFWQWSSFSDYVQCVLAFTGVAGYITYLSIDSALFVETLGFLAVLTEAMLGVPQLYRNHRHQSTEGMSIKMVLMWTSGDAFKTAYFLLKGAPLQFSVCGLLQVLVDLAILGQAYAFARHPQKPAPHAVHPTGTKAL
What are the official names of this protein?
Solute carrier family 66 member 2, PQ-loop repeat-containing protein 1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: OSPB_BORBG
Sequence: MKQYLLGFTLVFALIACAQKGANPEQKGGDADVLNTSKTEKYLNKNLPSEAEDLVSLFNDSEIFVSKEKNKDGKYVLRAIVDTVELKGVADKNDGSEGKLEGLKPDNSKVTMSISKDQNTITIETRDSSNTKVASKVFKKDGSLTEESYKAGQLDSKKLTRSNKTTLEYSDMTNAENATTAIETLKNGIEFKGSLVGGKATLQIVESTVTLTREIDKDGKLKIYLKDTASSSKKTVSWNDTDTLTISAEGKKTKDLVFLTDGTITVQNYDSASGTTLEGTATEIKNLEALKTALK
What are the official names of this protein?
Outer surface protein B.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: YPRO_OWEFU
Sequence: IRLLHSLTPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPRRARIHHNIPLFLRFFKKSYSSHFHWRCGQRNHCHSFVCKRLLVAYPVRHFLSAACQFLPWLSINSFSGTEMLNNRFHGLITL
What are the official names of this protein?
Uncharacterized proline-rich protein.
Protein: RL4_DESVM
Sequence: MAVVKVYDQNKKEAGELTLAPEVFEVEVKPEILNLVVRAHRAGLRSGTHATKTRAFVSGGGAKPWRQKGTGRARSGSNRSPIWRGGAVIFGPQPREYGFKVNKKVRQLALKMALSSRLAGENLMVVKGIELPEIKTKLFAKVAGALGLEKALVITAEADTTLALSARNIPGITLITADQLSVYEILKHPKLVMFEGAVESVQARLK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: EF1A2_TRYB2
Sequence: MGKEKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAADIGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILIIASAQGEFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVNYGQERYDEIVKEVSAYIKKVGYNVEKVRFVPISGWQGDNMIEKSEKMPWYKGPTLLEALDMLEPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGVMKPGDVVTFAPANVTTEVKSIEMHHEQLAEATPGDNVGFNVKNVSVKDIRRGNVCGNTKNDPPKEAADFTAQVIILNHPGQIGNGYAPVLDCHTSHIACKFAEIESKIDRRSGKELEKAPKSIKSGDAAIVRMVPQKPMCVEVFNDYAPLGRFAVRDMRQTVAVGIIKAVTKKDGSGGKVTKAAVKASKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha 2, EF-1-alpha 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBD4_ARATH
Sequence: MKEEEEIGKPAKPKAKKDVAPGRLIDTYAAQCDNCHKWRVIDSQEEYEDIRSKMLEDPFNCQKKQGMSCEEPADIDYDSSRTWVIDKPGLPKTPKGFKRSLVLRKDYSKMDTYYFTPTGKKLRSRNEIAAFVEANPEFRNAPLGDFNFTVPKVMEDTVPPDPKLGSPFPSTTTTTSEKSSVKQSHN
What is the function of this protein?
Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status.  Plays probably a role in gene silencing.
What are the official names of this protein?
Methyl-CpG-binding domain-containing protein 4, AtMBD4, MBD04, Methyl-CpG-binding protein MBD4.
What are the subcellular locations of this protein?
Nucleus.
Protein: TAL_ANADF
Sequence: MQFFIDSADVGEIKKALALGLCDGVTTNPSLVAKTGRSFDDVLKEIVALAPGPISAEVTATDAEGMLREARAYAKYGDQVVIKIPLIVEGLRAVKVLSQEGVKTNVTLCFSAVQALLAAKAGATYVSPFVGRLDDISQDGMQLIADILEIYRNYDFDTKVLVASVRHPVHVLEAARLGAHVATIPFGVIEQLAKHPLTDAGLKKFLADWEKVPKR
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC23_RHOPL
Sequence: QDAAKGEAVFKQCMTCHRADKNMVGPALAGVVGRKAGTAPGFSYSPLNHHSGEAGLVWTQENIITYLADPNAFLKKFLTDKGHADQAVGATKMTFKLANEQQRKDVVAYLATLK
What is the function of this protein?
Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway.  However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.
What are the official names of this protein?
Cytochrome c2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CSPE_BACAN
Sequence: MTLTGKVKWFNSEKGFGFIEVEGGNDVFVHFSAITGDGFKSLDEGQEVSFEVEDGNRGPQAKNVVKL
What is the function of this protein?
Can bind to ATTGG and CCAAT motifs (Y-box motifs) of single-stranded oligonucleotides.
What are the official names of this protein?
Cold shock-like protein CspE.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXOC6_DROME
Sequence: MSKVTVQDIEAVDDYWGPTFRSILEGNNTKQIGDQLEQRIRSHDKEIERICNLYYQGFIDSIQELLQVRTQAQQLHNEVHSLDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKFTQQAKNKQYYQALRTLETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSASDFREFLENIRKFSPRIGELAITHTKQLQKRDINAIIAEHMQQMNGGEAGGAGAGGDDDGANVSAQDLIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPPPNMHDNLEAYKTYICAIVGFFVVEDHVKNTAGDVVTSSYLEDLWSSSLTKFVNEISMSSSSCTDPNILLRIKNLIMLSINTFKCYGYTVNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIERFPFHSEQLENAPFPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNEVAAMVRKAANLLLTRSFSGCLSVVFRQPSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTNTERSVSQTPSAMFHVARQDAEKQVGLRICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTFDSFAFKLPHIAQAACRRTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEFFAASEPVPGLKEGELSKYFLRNRQLLDLLILEEWSTYFHDYGKQENRYHLVQPQSIIVILEKIREADKKPIFSLVRKNDKKKLLETVLKQLKHIADRQN
What is the function of this protein?
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
What are the official names of this protein?
Exocyst complex component 6, Exocyst complex component Sec15.
What is the protein family that this protein belongs to?
Belongs to the SEC15 family.
Protein: P32K_ADES1
Sequence: MYQQNAAGLAGTAFLMKSRGGAVRRRKVTRRRPTGRKTAARRRTDALRKAVRELIRRVKPRSPRQTGARSAPKSPESSYDFLRSGTPRYERDSRRPPADRVVMIDRESVWKGAQVPQPPQQPMWFPPWMMQWQHAPSRPCRAVLPAPVRIREEEGNAQIFKDARDVAEGNYLPRRPADGEADRDNRVRNRWSLEQVLRTLERIPARGRKLILTGLFGTAVGVVLDLLLGSPLNLTTRLVRLIVGFVPGGNLILNALDGLGYLMSRFPSNPLQITYDPGFQRLANSVQQNIPQGTAEALAHAAEQQVGEGFARNLAAAMSYLVGSAPSAAPMAIPLALVRPFRP
What are the official names of this protein?
Structural protein p32K.
What is the protein family that this protein belongs to?
Belongs to the atadenoviridae p32K protein family.
What are the subcellular locations of this protein?
Virion.
Protein: CAV2_SHEEP
Sequence: MGLETEKADVQLFMDDDSYSRHSSVDYADPDKFVDPGSDRDPHRLNSHLKVGFEDVIAEPVSTHSFDKVWICSHALFEMSKYVIYKFLTVFLAIPLAFAAGILFATLSCLHIWIIMPFVKTCLMVLPSVQTIWKSVTDVVIAPLCTSVGRSFSSVSLQLSHD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin. Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane (By similarity).
Protein: PRIPO_CHICK
Sequence: MKRKWEERVKKVEELASYYERNPLPTVYKPRLSKPLQPSRVWKIFCRQADAFRFVKTCKEDVHVFALERNTQNGQRFYLVTTYQELWYYYTKGYKTSLMHCYEVIPEKDACKLYFDLEFYKAANPGADGKDMVAKLIELVSQKLKELYDVNCSARDVLNLDSSTDEKFSRHLIFLPCKTVFKDNIHVGNFVRTILQPAIRLVGSNVAAPIAEGGAGYTSQCSAPTVELDGPLTNLTAVEDASKGWPAIADQRKETETSHHGENSEFSFLIVNNKEGDKQLFVDLGVYTRNRNFRMYKSSKAGKNVILTIAEDNKFVPNCEENVSLEEAYFLSSLVCNVRFEDGTKILSSNFVEEEIKMSAFLRSKTTRSTREPMEGYQESPYPEIDCFVRSLINKDGVQGGIRQWNYFSGEEILVYDISGYRWCENIGRAHRSNNIMILVDLKKEVWYQKCHDPVCREKNFKSQSLPLPSRICLSSLFIEEEDHMVTDERENTEVTSHSNPADLSESSAYLAINTSQDTQWDNASDDAYLVETAEDVELAEAADYSLGYDTEEIPDEVLLEMSWKQDTCSKDDS
What is the function of this protein?
DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them (PubMed:26626482).  Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (PubMed:26694751, PubMed:27230014).  Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity).  Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as UV lesions, R-loops and G-quadruplexes, to allow DNA replication to continue (PubMed:26694751, PubMed:27230014, PubMed:26626482).  Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion (By similarity).  Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase (By similarity).  Also required for reinitiating stalled forks after ultraviolet (UV) damage during nuclear DNA replication (By similarity).  Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (By similarity).  In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity).
What are the official names of this protein?
DNA-directed primase/polymerase protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion matrix. Chromosome.
Protein: PANB_RHOJR
Sequence: MSDSKSSASTSEDRLYGSAPSHDVPKRKTRTHHLQAMKAEGERWAMLTAYDYSSARIFEEAGIPVLLVGDSAANVVYGYETTVPVTIDELLPLVRGVVRGAPHALVVADLPFGSYESSPEQALASATRFMKEGLAHAVKLEGGERVAPQIAAITAAGIPVMAHVGFTPQSVNSLGGFRVQGRGDAAEQLVADAIAVQEAGAFSVVMEMVPAEIAGQVTRKLTIPTVGIGAGVECDAQVLVWQDMAGYTSGKTAKFVKRFGNVGDELRSAAAAYATEVRAGTFPAEEHSF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANE_STRPG
Sequence: MPDKPTKEKLMEQLKGGIIVSCQALPGEPLYSETGGIMPLLAKAAQEAGAVGIRANSVRDIKEIQAITDLPIIGIIKKDYPPQEPFITATMTEVDQLAALNIAVIAMDCTKRDRHDGLDIASFIRQVKEKYPNQLLMADISTFDEGLVAHQAGIDFVGTTLSGYTPYSCQEAGPDVALIEALCKVGIAVIAEGKIHSPEEAKKINDLGVAGIVVGGAITRPKEIAERFIEALKS
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: ACPS_XANP2
Sequence: MIIGIGSDFSDARRIARSIERFGDRFLDRVFTPGERRKADQRKLRAETYAKRFAAKEACSKALGTGLSHGVFWRDMEVVNLPSGQPTLMLTGGAARRLAALVPDGYEPHIHLSLTDEGPLTAAYVIISAVPKTGV
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPD_STAES
Sequence: MSLSTLKRDHIKKNLRDTEYDVVIVGGGITGAGIALDASNRGMKVALVEMQDFAQGTSSRSTKLVHGGLRYLKQLQVGVVAETGKERAIVYENGPHVTTPEWMLLPMHKGGTFGKFSTSIGLAMYDRLAGVKKSERKKMLSKQETLNKEPLVKRDGLKGGGYYVEYRTDDARLTIEVMKKAAENGAEILNYTKSEHFTYDSNKKVNGIEVLDMIDGETYAIKAKKVINASGPWVDEVRSGDYARNNKQLRLTKGVHVVIDQSKFPLGQAVYFDTEKDGRMIFAIPREGKAYVGTTDTFYDNEKATPLTTQEDRDYLINAINYMFPTVNVKDEDIESTWAGIRPLILEKGKDPSEISRKDEVWEGESGLLTIAGGKLTGYRHMALEIVDLLAKRLKQEYGLKFESCATKNLKISGGDVGGSKNFEHFVEQKVDAAKGFGIDEDVARRLASKYGSNVDQLFNIAQTAPYHDSKLPLEIYVELVYSIQQEMVYKPTDFLVRRSGKLYFNIQDVLDYKNAVIDVMADMLNYSETQKEAYTEEVEVAIDEARTGNDQPATKA
What are the official names of this protein?
Aerobic glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y939_PSEMY
Sequence: MPSFDVVSELDKHELTNAVDNAIKELDRRFDLRGKCSIESKDKTLTLTAEAEFMLEQMLDIVRSSLIKRKIDCQCMEAKDPYASGKVMKQEVTFREGIDKELAKKIVAHIKDAKLKVQAAIQGEQVRVTGKKRDDLQEAIALLRGHEFGMPLQYNNFRD
What are the official names of this protein?
UPF0234 protein Pmen_0939.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: CITD_SHISS
Sequence: MKINQPAVAGTLESGDVMIRIAPLDTQDIDLQINSSVEKQFGDAIRTTILDVLARYNVRGVQLNVDDKGALDCILRARLEALLARASGIPALPWEDCQ
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein, Citrate lyase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQAR_BACSU
Sequence: MIQIDFGTVITSAITAVFFTGGTNYVLQKKNRKGNEIFTKGYILIDEIYNINNKRIETAAAFVPFYNHPEGYLEKLHTDYFKELSAFELIVKKFSILFDKELNIKLQEYINYLREVEVALRGFMNDDPIIEVNFNQEYIERLIDEITNLIKKHI
What are the official names of this protein?
Uncharacterized protein YqaR.
Protein: SAST_RAT
Sequence: METAVNAKSPRNEKVLNCLYQNPDAVFKLICFPWAGGGSIHFAKWGQKINDSLEVHAVRLAGRETRLGEPFANDIYQIADEIVTALLPIIQDKAFAFFGHSFGSYIALITALLLKEKYKMEPLHIFVSGASAPHSTSRPQVPDLNELTEEQVRHHLLDFGGTPKHLIEDQDVLRMFIPLLKADAGVVKKFIFDKPSKALLSLDITGFLGSEDTIKDIEGWQDLTSGKFDVHMLPGDHFYLMKPDNENFIKNYIAKCLELSSLT
What is the function of this protein?
Contributes to the release of free fatty acids from fatty acid synthase (FASN).  Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).
What are the official names of this protein?
S-acyl fatty acid synthase thioesterase, medium chain, Medium-chain S-acyl fatty acid synthetase thioester hydrolase, Oleoyl-ACP hydrolase, Thioesterase II, Thioesterase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the thioesterase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PRIO_OVICA
Sequence: MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.