PharMolix/UniProtQA huggingface dataset:
Protein: SCM2B_DANRE
Sequence: MLCLCLYVPVHISERTEFEYFESESLPVQLKSLFKLSLFLPSQEFDSYRKWRKKVVKAGDKDLDGQLDFEEFVHYLRDHEKKLRLVFKSLDKKNDGHIDSQEIMQSLRDLGVHISEEQAEKILKSMDKNGTMTIDWNEWRDYHLLHPAENIPEIILYWKHSTIFDVGESMLVPDEFTAEEKNTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHATRSNSMGIAGGFTQMIREGGLRSLWRGNGINVLKIAPESAIKFMAYEQIKRLIGSNQETLGILERLVSGSLAGAIAQSSIYPMEVLKTRLALGRTGQYSGIADCAKHIFKKEGMTAFYKGYIPNMLGIIPYAGIDLAVYETLKNSWLQRFATDSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASQEGSPQMTMSGLFRHIVRTEGAIGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
What is the function of this protein?
Calcium-dependent mitochondrial solute carrier.
What are the official names of this protein?
Calcium-binding mitochondrial carrier protein SCaMC-2-B, Small calcium-binding mitochondrial carrier protein 2-B, Solute carrier family 25 member 25-B.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PLK1_PEITU
Sequence: AEKDCIAPGAPCFGTDKPCCNPRAWCSSYANKCL
What is the function of this protein?
Binds reversibly and blocks N-type voltage-gated calcium channels (Cav).
What are the official names of this protein?
Toxin Ptu1.
What is the protein family that this protein belongs to?
Belongs to the venom Ptu1-like knottin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GATB_MYXXD
Sequence: MPVSDFQPVIGLEVHAQLLTQSKIFCGCSTAFGAEPNRNTCPVCLGMPGVLPVLNQRVAEFAVRTGLALECTIRPTSVWSRKNYFYPDLPKGYQITQFDQPICEHGRLVIDTPQGEKAIRILRIHMEEDAGKSVHDAGGGQSLVDLNRAGVPLLEIVSQPDLRDADEAVEYLKAMRDVLVYLGVNDGNLEEGSFRCDANVSVMPKGSTTFGQRCELKNLNSFRFLKQAIEYEIARQVDVIESGGKVVQETRLWDVNKGVTRSMRSKEEAHDYRYFPEPDLPPLHVSAEAIAAAAKALPELPRAKLQRFTSQYGLPAYDARILTAERPLADYFEACAGHYKDYKKLSNWFLGELMRLLKEEGTPLSALRFTPAQLGELLGAVDQGMVSANAGKDVLGEMFRTGKAPADIIAEKGLAQVSDTGAIEAVVDDILAKNAGEIEKYRAGKKQVFGFFVGQVMRAMKGKGNPALVNELLKKKLGD
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: LEU1_BACC0
Sequence: MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYALFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: RSRC2_PONAB
Sequence: MAASDTERDGLAPEKTSPDRDKKKEQSDVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEARRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDAV
What are the official names of this protein?
Arginine/serine-rich coiled-coil protein 2.
What is the protein family that this protein belongs to?
Belongs to the RSRC2 family.
Protein: PER8_CAPAN
Sequence: VVSCADILTLAAR
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 8.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: COBQ_MYCS2
Sequence: MTGGALLVAGTTSDAGKSMLVGGLCRLLVRKGLSVAPFKAQNMSNNSAVTVEGGEIGRAQAMQARAAGLAPSVRFNPILLKPGGDRTSQLVVRGQVTGSVAAADYINHRDHLAAVVADELSSLREDFDAVICEGAGSPAEINLRATDLANMGLARAAALPVIVVGDIDRGGLLAHLHGTVAVLEPADQALVSGFVVNKFRGDPSLLAPGLRQLAELTGRPTYGVIPFHDEIWLDTEDSVSVRPGGLVGAPEPPRGEQTLTVAAIRLPRISNSTDIEALACEPGVVVRWVTDAADLTGADLVVIPGSKATVTDLRWLRERGLAAGIAAHAAAGRAVLGVCGGFQMLCSRIDDPVESREGRVDGLGLLDADIEFAAQKTLRHWETPLHGYEIHHGQVARSAETDWLGIGLRRGAVYGTHWHGLLDNDALRRDWLTEVAAAAGRDGFVVADDVDVSARRDAQLDLMADLIENHLDVGAILDLLEHGAPHRPTMSTALHV
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: AIM41_YEAS2
Sequence: MFRQSIRPLVSNRLTFIRYNSSPAYTAAVSLLKGDLKKAMIAKDEMKKTAIRNMLSAIKNKEIALKGKSADEYSLYDMYSKLISQRKDSINEFLANKRDDLVAKEQGEMDIIKKYMDQLPVSSELDIDQNVKKLLDALKTKAGEKKVQIKEIMGEIDWKSLPTEWKTSPTAIKNSIVKQFKEIFK
What are the official names of this protein?
Altered inheritance of mitochondria protein 41, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM41 family.
Protein: NNJA1_ORYSJ
Sequence: MEGFSRDLLCGIGKGGDGPRGEVRPRVDMEAEEVELNLGLSLGGRFGLDRRGEKLARSSSVAAILAAPTEPSAPPSGLFRTSSLPTVAAAEAAKKQGVDELNCRRPSGGAEAEPAAARLPASGSPSSGSSDGEGRRLEVNMTDTLMRTSSLPAGIEDEWRKRKEAQSLKRLEVKRKRIERRNSLTSNISKEAVGQILEEMNAGAEKVESCDDVATGNKKTGGNVNHSSDRNRCTGLPPVHRATYTQQRGSLSGIPTKHIPAMKGSADAEEHNVPSAATEHRNGAAIATPPFSALAVRAVALASRGEQLRATGRVAARAKSMGDVERIMMQEMPCVCTKGLPNGKRVEGFLYKYRKGEEVRIVCVCHGSFLTPAEFVKHAGGGDVANPLRHIVVNPIPPSLY
What is the function of this protein?
Acts as negative regulator of abscisic acid (ABA) signaling and drought tolerance.  Mediates deactivation and degradation of BZIP46, a positive regulator of ABA signaling and drought stress tolerance.  Represses BZIP46 activity via interaction with the TPR3-HDAC1 corepressor complex and down-regulation of the histone acetylation level at BZIP46 target genes.  Promotes BZIP46 degradation via interaction with the U-box type ubiquitin E3 ligase PUB70.
What are the official names of this protein?
Ninja-family protein MODD, Protein MEDIATOR OF OSBZIP46 DEACTIVATION AND DEGRADATION.
What is the protein family that this protein belongs to?
Belongs to the Ninja family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS5_BRUAB
Sequence: MRVAIIDYGSGNLRSATKAFERAAHESGISAEIDLTCDAQRVASADRIVLPGVGAYADCRRGLDAAPGMVEALNDTVLKKARPFLGICVGMQLMSERGLEKTVTNGLGWIAGDVREMVPSDASLKIPQIGWNRIHVKHSHPIFDGIPTGDDGLHAYFVHSYMLDAKNASDVLAVTDYGGDVTAAVGRDNMVGTQFHPEKSQLLGLSLIANFLKWKP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIP2A_MOUSE
Sequence: MADRGCPLEAAPLPAEVLESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQDVHTEAVQAALAKYKERKMPMPSKRRSALVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTLLQSHSGIEPWLDRVIQGSSTSSSASSTSSHPGGRPAAAPSASTALAGLTAHAHIDLHSAPPDVTTGLVEHSSYERPQMASVRGIPRGHGRNVLETADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGDQMAVLKGEPLSVGTNGPLSLLAALQLWGTTQPKAPCLTALDTAGKATCTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLNPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQQVGFLLGSCGVTLALTTDACQKGLPKAPTGEVATFKGWPPLAWLVIDGKHLTRPPKDWYPLAQDTGSRTAYIEYKTSKEGSTVGVTVSHSSLLAQCQALTQACGYTEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVITIPYALMKVNPLSWIQKVCSYKARAALVKSRDMHWSLLAQRGQRDVCLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRPPDLGGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGASVCVVKVDGAPYLCKTDEIGEICVNSVATGTAYYGLLGITKNTFETVPVTADGVPVSDRPFTRTGLLGFIGPDNLVFVVGKLDGLMVVGVRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLGGIHISETKQRFLEGTLHPCNVLMCPHTCVTNLPKPRQKQPEVGPASMIVGNLVAGKRIAQASGRELAHLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTATCIQLHKRAERVAAALMEKGRLDAGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSACVLSTQAITRLLKSKEAAAAVDVRTWPTILDTDDIPKKKVASIFRPPSPDVLAYLDFSVSTTGILAGVKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGAQTGALRMKGVNLSCVRTCMVVAEERPRISLTQSFSKLFKDLGLPARAVSTTFGCRVNVAICLQGTTGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEETLHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDASGERHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVELDGLEQDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM
What is the function of this protein?
Catalyzes the de novo synthesis of acetyl-CoA in vitro (PubMed:30672040).  Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (PubMed:31600191).  Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (By similarity).
What are the official names of this protein?
Disco-interacting protein 2 homolog A, DIP2 homolog A.
What is the protein family that this protein belongs to?
Belongs to the DIP2 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Mitochondrion. Cell projection, dendritic spine.
Protein: BCHB_CHLSY
Sequence: MRLAYWMYEGTAHHGVGRIANSMRNVHAVFHAPQGDDYVNAIFAMLDRTPNFPAMTTSVVSGTDLARGTIRLPDTLRQVEERVHPDLIVVVASCSTILLQENLEIAAQHAGLQCEVMVYDANPYRMQEIVAAESLFTDLVKRFAKPQPRTERPTVNILGPASLGFHARHDLISLRRMLKTLGLEVNVVAPWGASIADLRRLPAAWLTIAPYRELGLRAAIYLEEQFGVPALLDAPIGVQPTLRWIERLRELLAQAGADVPMPPLTAFSLDGMSAPSAVPWFARTADMDSFSGKPAFVFGDATHVVGVTRFLRDELGMPIAGAGTYVKHQADWVREQLTGYVDEVLVTDEFQVVADRIAALRPELVCGTQMERHTSRRYDLNCMVISPPTHIENHLLAYRPFLGFDGADVIADEVYTTCTLGMEKHLIDLFGDAGLDLPEKTERTPVAEPAPVAATVESPQPQNEPAIAVASAPSLTSAPATPTPAAVVDPVWAADAEAMLKKVPFFVRGRVRGNVEKYARQRGHAVITAEVLLAAKEELGA
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: PRAL7_MOUSE
Sequence: MVSAPPTLQDQAFRSLVRNEVLTVSDAECLIREFFPPLFKEASTQKKPKTIMILVEHWPYPCLHVGLLIDKPNFQIFQAILDGVDTWLKRKYRPRMGRLKKVDFRDAQHHASLDMQDEREGRDYLVGTLPKKQIVEDHSRTRKERLKLFHDLSFMSSLHEDKHQTLLLEWAKERTSFLHLCCEKLEIGAVEVSKVRNVLKFLQPELIKELKLNTVGNLSKLAKFVPFIRKMRNLQKLMLVRTFGTRTFTQEEKQNISKIISLFCKLSCLRHLTIDDVYFLTDQMKELLRCLEAPLVSLKITLCQLSQSDLESFAQRWNYSQLKHLCLRGVTLTNLDVTPLRDFLKRVAANLQTLDLEDCRMDDSHFRTLLPALIKCTQLTSINLYDNDISEDVLENFLHRTTNLSQLTTEMYPAPSEVYNESNYVIVEIFIQICSELMNKLMEVRQANSVCFGSSSCYDCDNRYLYEDDGDVTLCLCQE
What is the function of this protein?
Promotes maintenance and self-renewal of pluripotent embryonic stem cells (ESCs), downstream of LIF/STAT3 (PubMed:21425410).  Maintains the pluripotency state of ESCs by repressing DNA methylation through the regulation of UHRF1 stability.  Mediates the proteasomal degradation of UHRF1.  Is required for the establishment of the blastocyst (PubMed:28604677).
What are the official names of this protein?
Preferentially expressed antigen in melanoma-like protein 7, Prame-like 7.
What is the protein family that this protein belongs to?
Belongs to the PRAME family.
Protein: VF453_IIV6
Sequence: MYQQKYFEKPVYYLQRNDFDDNGNLIVPELRNKKVIIMIQANYCGHCTNAKGDYYKAAKYIKELEKNGGTSYKNKVVFATIQADGDEEGEKELNQILDKIKPTFVGFPDYVLYVNGKRIEDDGPPGRNFNNIVNYVMG
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Putative thioredoxin-like protein 453L.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: SYE_BURP6
Sequence: MTRPVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGTFVLRIEDTDLERSTEASVDAILEGMAWLGLDYDEGPYYQMQRMDRYREVLAQMLEKDLVYPCYMSTEELDALRERQRAAGEKPRYDGTWRPEPGKVLPEPPAGVTPVLRFRNPLTGSVVWDDAVKGRVEISNEELDDLVIARPDGTPTYNFCVVVDDLDMGITHVIRGDDHVNNTPRQINILRALGGEVPVYAHLPTVLNEQGEKMSKRHGAMSVMGYRDAGYLPEAVLNYLARLGWSHGDAEIFSREQFVEWFDLEHLGKSPAQYDHNKLNWLNNHYIKEADDARLAELAKPFFAALGIDADAIARGPDLVGVMGLMKDRASTVKEIAENSTMFYRAPAPDAQALAQHVTDAVRPALAEFAAALKTAEWTKEAIAAALKAVLGAHKLKMPQLAMPVRLLVAGTTHTPSIDAVLLLFGRDVVVSRLAAALA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHE_HUMAN
Sequence: MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLPYAPCIQP
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: HIS1_ALBFT
Sequence: MITLALSKGRIFEETLPLLRAAGIEVLEDPEKSRKLILTTNQPNVRVLVVRASDVPTYVQYGGADLGITGKDTLLEHGSDGLYQPLDLQIAKCRISVAVRADFDYASAVKQGSRLRVATKYVAISREFFAAKGVHVDLIKLYGSMELAPLVGLSDAIVDLVSTGNTLKANHLVEVEHIMDISSRLVVNQAALKLKQAPIRKIIDAFASAISQ
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_CORGL
Sequence: MTMTDPIADMLSRVRNASNAHHDTVSMPSSKIKANIAEILKQEGYIANYTVEDAKVGKTLSLELKYSNTRERSIAGLRRVSKPGLRVYAKSTNLPQVLGGLGVAIISTSQGLLTDRQATEKGVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RNJ2_STAAC
Sequence: MSLIKKKNKDIRIIPLGGVGEIAKNMYIVEVDDEMFMLDAGLMFPEDEMLGIDIVIPDISYVLENKDKLKGIFLTHGHEHAIGAVSYVLEQLDAPVYGSKLTIALIKENMKARNIDKKVRYYTVNNDSIMRFKNVNISFFNTTHSIPDSLGVCIHTSYGAIVYTGEFKFDQSLHGHYAPDIKRMAEIGEEGVFVLISDSTEAEKPGYNTPENVIEHHMYDAFAKVRGRLIVSCYASNFIRIQQVLNIASKLNRKVSFLGRSLESSFNIARKMGYFDIPKDLLIPITEVDNYPKNEVIIIATGMQGEPVEALSQMAQHKHKIMNIEEGDSVFLAITASANMEVIIANTLNELVRAGAHIIPNNKKIHASSHGCMEELKMMINIMKPEYFIPVQGEFKMQIAHAKLAAEAGVAPEKIFLVEKGDVINYNGKDMILNEKVNSGNILIDGIGIGDVGNIVLRDRHLLAEDGIFIAVVTLDPKNRRIAAGPEIQSRGFVYVRESEDLLREAEEKVREIVEAGLQEKRIEWSEIKQNMRDQISKLLFESTKRRPMIIPVISEI
What is the function of this protein?
An RNase that has 5'-3' exonuclease and possibly endoonuclease activity.  Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity).
What are the official names of this protein?
Ribonuclease J 2, RNase J2.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCF5_ORYSJ
Sequence: MGDAGGHSHHHQHGFQPQLLSFGGVGHHHHLHQFTAQPQPPAASHTRGRGGGGEIVPATTTPRSRGGGGGGGGEIVAVQGGHIVRSTGRKDRHSKVCTARGPRDRRVRLSAHTAIQFYDVQDRLGYDRPSKAVDWLIKNAKDAIDKLDVLPAWQPTAGGAGAGNAAAPPSSSTHPDSAENSDDQAQAITVAHTAFDFAGGGSGGTSFLPPSLDSDAIADTIKSFFPMGGTAGGEASSSTTAAQSSAMGFQSYTPDLLSRTGSQSQELRLSLQSLPDPMFHHQQHRHGGGGGGGNGTTQQALFSGAANYSFGGGAMWATEQQAQNQRMLPWNVPDPGGGGGAAYLFNVSQQAAHMQAAAAALGGHQSQFFFQRGPLQSSNQPSERGWPETVEADNQMSHHQGGLSPSVSAAIGFAAPGIGFSGFRLPARIQGDEEHNGGGGGNGDKPPPPSSVSSASHH
What is the function of this protein?
Transcription activator.  Binds the promoter core sequence 5'-GGNCC-3'.
What are the official names of this protein?
Transcription factor PCF5.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL17_DECAR
Sequence: MRHRNGLRKLNRTSSHRLAMLRNMTVSLLKHEAIKTTVPKAKELRRVVEPIITLGKNPTLANKRLAFDRLRDRDIVVKLFAEIGPRYATRPGGYLRILKCGFRVGDNAPMAFVELLDRPEVTEAVEIEDAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: SREK1_MOUSE
Sequence: MTSLVPGAGLLPIPTSSPLTAVSSLGVSLSSLGAIPAAALDPNITTLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSRSRDKRKDTREKVKERVKEKEREKEREREKDREKDKERGKNKDKDREKEKDHEKERDKEKEKEQDKDKEREKDRSKETDEKRKKEKKSRTPPRSYNASRRSRSTSRERRRRRSRSSSRSPRTSKTVKRKSSRSPSPRGRNKKEKKREKERDHISDRRERERSTSTKKSSGDRDGKEKVEKSTTPVKEKEHSKESDATVSKAADEKGSPRTEDEGKVQHNGNCQPNEESPCSKADAV
What is the function of this protein?
Participates in the regulation of alternative splicing by modulating the activity of other splice facors.  Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6.  Augments the splicing activity of SFRS3 (By similarity).
What are the official names of this protein?
Splicing regulatory glutamine/lysine-rich protein 1, Serine/arginine-rich-splicing regulatory protein 86, SRrp86, Splicing factor, arginine/serine-rich 12.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NADD_MYCPA
Sequence: MGGTFDPIHYGHLVAASEVADLFGLDQVVFVPSGQPWQKDRHVSAAEDRYLMTVIATASNPRFSVSRVDIDRAGPTYTRDTLRDLHALNPDSELFFITGADALASILSWQGWETLFELAHFVGVSRPGYELCREHITGVLGELPDDALTLVEIPALAISSTDCRQRAAQRRPLWYLMPDGVVQYVSKRRLYRAEPGPAVAVTETRLSTGDHP
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: YL859_MIMIV
Sequence: MSNTDALNTANTQITENVDTSSMKVEKTHDSDPMKITNTSFALEMTQHLFEDLVAHGYKNIVKHEVYPGPIIDLQNLVRVMTKGTFIPIKMEDIKDLHDFVMDRLSEFDCSCLGHLCPKEYMIQIWKAGRIQSEFYYCYNYQLQDLSQIYPFVIEWILKRDDMPLNLDKESYEATALMMSKLLESLIKFGNEKIEFVKFYKLCGHIQCPCEKKPASYLDVKKLVGVLTDGGIIGFEGLTKLYVHLEKSIQEIDDRWSHWLPGRTRKPIYYKTFTKGRVTQLSIKCYSFYLQEIALIAYVVTQFILQEKPDLSYRA
What are the official names of this protein?
Uncharacterized protein L859.
Protein: TATA_HERA2
Sequence: MAGLGVTELLIILAIVIVLFGASRIGDLGGAMGRGIREFRRGVRDEDATAPTDASKNESK
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: IMA6_RAT
Sequence: MDSMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPRNDDCMLESPIQDPDVSSTVPIPEEDMITADMIQMIFSNNAEQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIRLLTSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQVVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLGSPKESVRKEACWTISNITAGNRMQIQAVIDGSIFPVLIEVLQKAEFRTRKEAAWAITNATSGGAPEQIRYLVTLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGERESKQNGVGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIERYFGVEEDDPSLVPQVDEQQRQFLFQQCEAPGEGFQL
What is the function of this protein?
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1.  Binds specifically and directly to substrates containing either a simple or bipartite NLS motif.  Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.  Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9 (By similarity).
What are the official names of this protein?
Importin subunit alpha-6, Karyopherin subunit alpha-5.
What is the protein family that this protein belongs to?
Belongs to the importin alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_BUCAT
Sequence: MYAVFISGGKQYRVVKNQIIRLEKLNSPLGTTIEFDKILMLFDKDSIKIGTPFVEGGTIKAHIQNHGRLKKIKIIKFNRRKHYKKQQGHRQYFTDVKIIDINSIKGEV
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.