PharMolix/UniProtQA huggingface dataset:
Protein: ARLY_STUS1
Sequence: MSTDKTNQSWGGRFSEPVDAFVARFTASVEFDKRLYRHDIMGSIAHATMLAKAGVLTDAERDQIIANLKDIQSEIEAGTFDWRVDLEDVHMNIEARLTDRIGIVGKKLHTGRSRNDQVATDIRLWLRDEIDVILGEITRLQQGLLGLAEAEADTIMPGFTHLQTAQPVTFGHHLLAWFEMLSRDYERLVDCRKRTNRMPLGSAALAGTTYPIQREITCELLGFEAISGNSLDGVSDRDFAIEFCAAASVAMMHLSRFSEELVLWTSAQFQFIDLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVFGALTGLLALMKGQPLAYNKDNQEDKEPLFDAADTLRDSLRAFADMVPAIKPKREIMREAALRGFSTATDLADYLVRKGLPFRDCHEIVGHAVKYGVQTGKDLAEMTLDELRQFSGEIGDDVFAVLTLEGSVNARDHIGGTAPAQVRAAVKRGQALLAGR
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Protein: ORYC_ASPOR
Sequence: MTVLTREKKPYFGLTGGWLTFWVTVACATDMSLFGYDQGVFSGVVITRDFLEVHDLVGPEKTKTLSTVTAIYDVGCFFGAIVAFTIGEQLGRKKAILLGTTIMAIGAVLQAASFSLAQMFVGRIILGIGNGINTATAPIWQTETSQLKWRGKLVIFEMMMNIFGFCLVNWINYGLSFVGGSIAWRFPLAFQFFFLIILWSTTPWLPESPRWLIAHGRQEEATVVLSCLEAKPIDDPFVIAQRNEIEFSVRYERENSMRWRDLCQKKGNDSKTLRRLLLGAGSQFMQQFGGINIMSYYLPTVLMDSVGLSDTMARLLAACNALSYLVFSGLAVLLVERIGRRGLMLLSTFGQFLCFLIITILLRFSRISDNGEKFASASVAFFFLYYGAFGIGMLGVPWLYPTEINSLPMRTKGAAVATATDWITNFVVVEITPIGIKNIDWKFWIVWTVTNAAFLPILYFLYPETANRSLEDMDEYYRSNPALVVTKDPDAICRRRPQKYLQREEEEIERAAAAVDKRALSVGAVEHAEWTNAMGNKS
What is the function of this protein?
MFS-type transporter; part of the gene cluster that mediates the biosynthesis of oryzines, natural products with an unusual maleidride backbone.
What are the official names of this protein?
MFS-type transporter oryC, Oryzines biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RECR_RHOP5
Sequence: MATAVAGPEIERLIQLLSRLPGLGPRSARRAALHLIKKREALMAPLASALQVAIERIQVCKTCGNIDTQNPCTVCTDPRRDPAIIVVVADVADLWALERAHASNGRYHVLGATLSPLDGVGPQDLTIDALVARAHDPQVSEIVLALNATVDGQTTAHYITDLLMEANVKVTRLAHGVPVGGELDYLDEGTLSAAMRQRTLF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RL4_ECO24
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: UVRB_COXBN
Sequence: MSKAFKLTSKFKPSGDQPQAIEKLVAGLEDGLAYQTLLGVTGSGKTFTIANAIEKVQRPTLILEPNKTLAAQFYAEMREFFPENAVEYFVSYYDYYQPEAYVPSSDTYIEKDASINDHIEQMRLSATKAITERHDTIIIATVSAIYGLGDPDSYLKMLLHLTRGDQIDQRKILQRLAELQYTRNDLELRRATYRVNGDIIDIYPADSEREAVRVELFDDEVENLSYFDPLTGEMLRRVPRITVYPKTHYVTPREKLLSTLDQIKIELKERLSQLEKANKLVERQRLEQRTKFDMEMILELGYCSGIENYSRYLSGRNEGEPPPTLIDYLPKDALLIIDESHVTIPQLGGMYRGDRARKETLVEYGFRLPSALDNRPLRFDEFEKLAPQTIFISATPGPYEEKQSDQVVELLVRPTGLIDPEIEVRPVATQVDDLLSEIKKRAAQNERVLVTTLTKRMAEDLTEYFTEHNVRVRYLHSDIDTVERVEIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTMGRAARNVHGKAILYADRITDSMKRAMEEAERRRIAQSAYNEKHHITPKSIQKAVTEIIEGARTYTERGRFVNQAQLIAEEESKYIAMTPKQLAKELRKLEEQMYHHARNLEFEEAAAVRDKIQHIRKGLLEVKE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_AERHH
Sequence: MNGIPMEHGLLLAAVLFCIGLCGLLIRRNLLFILMSIEIMMNASALAFVVAGSRWAQADGQIMYILVISLAAAEASIGLALLLLLYRRYHTLNVDTVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASCI_ACREG
Sequence: MPQLAGKLILAGLIPLGAWVLHGFASCNGLIQMFEDFGKQTVLSDGVTDYTGAFTGLEGLDRLLRTLLNFFWPVANGHDWALSLHAFMFAGQGVPLLVLNMLEGARPGNKSLVVSYVTVFGILYMVVGLAIMAPLYLFLHLLTSRTATAPSKAKVAVDPNTAKAVGFGVFVGYVLPTIFMSLPHPSLLSTDTKVLSVVFWQAVPLWASVCAYFASTALGQSATSRSSSNLPSALGAVYAASLIIATATHVATFAISANLSDTWSGIFTFLIPPNPFNTDMRISSFLEGATWFLQWDYTMMSLAYMVWAIGIRHGVEVPRSSHHFETLGKIALRSMAKLLVMGPIGAALSLVWERDQLLWQLDSESGEKGEKNRSRRMSRKWMFS
What is the function of this protein?
Epoxide hydrolase; part of the asc-2 gene cluster that mediates the biosynthesis of ascofuranone, a strong inhibitor of cyanide-insensitive alternative oxidases and a promising drug candidate against African trypanosomiasis (PubMed:30952781, PubMed:35418536).  The first step in the pathway is performed by the non-reducing polyketide synthase ascC that produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:30952781, PubMed:35418536).  Orsellinic acid is then prenylated by the prenyltransferase ascA to yield ilicicolinic acid B (PubMed:30952781, PubMed:35418536).  Ilicicolinic acid B is further reduced to ilicicolin B by the reductase ascB (PubMed:30952781, PubMed:35418536).  The halogenase ascD then chlorinates ilicicolin B to produce ilicicolin A which is converted to ilicicolin A epoxide by the cytochrome P450 monooxygenase ascE that catalyzes stereoselective epoxidation of the terminal double bond of the prenyl group (PubMed:30952781, PubMed:35418536).  Ilicicolin A epoxide is the last common precursor for the biosynthesis of ascofuranone and ascochlorin (PubMed:30952781, PubMed:35418536).  The terpene cyclase ascF produces a monocyclic terpene, and the cyclization reaction is proposed to be initiated by protonation of the terminal epoxide of ilicicolin A epoxide to generate a monocyclic tertiarycation, which is followed by a series of hydride and methyl shifts with abstraction of proton, leading to the formation of the (14S,15R,19R)-trimethylcyclohexanone ring structure of ilicicolin C, which is finally reduced to ascochlorin by the dehydrogenase ascG (PubMed:30952781).  On the other hand, ilicicolin A epoxide is hydroxylated by the cytochrome P450 monooxygenase ascH, and the resultant product is cyclized by the terpene cyclase ascI to ascofuranol via protonation-initiated epoxide ring opening, which facilitates the 6-endo-tet cyclization to form the tetrahy-drofuran ring (PubMed:30952781).  Finally, ascofuranol is oxidized into ascofuranone by ascJ (PubMed:30952781, PubMed:35418536).
What are the official names of this protein?
Terpene cyclase ascI, Ascofuranone/ascochlorin biosynthesis clusters protein I.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound ascI terpene cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RUBR_CHLTI
Sequence: MQKYVCSVCGYVYDPADGEPDDPIDPGTGFEDLPEDWVCPVCGVDKDLFEPES
What is the function of this protein?
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide.  Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
What are the official names of this protein?
Rubredoxin, Rd.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
Protein: SPAN2_BPMU
Sequence: MMQKKKLQPPLLVTIAALVLCLPLLLTGCGNSKNAPVPSVVILPEIDTELTEATPVPPMPQPLTWGASLLWNADLLMALGQCNRDKASVREQEIRRKEIYERRPEPGGGAAAR
What is the function of this protein?
Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit.  The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans.  Host outer membrane disruption is possibly due to local fusion between the inner and outer membrane performed by the spanin complex.
What are the official names of this protein?
Spanin, outer lipoprotein subunit, o-spanin, gene product 23.1, gp23.1.
Protein: LEU1_SALTI
Sequence: MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIINVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMGHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: EMP_STAA3
Sequence: MKKKLLVLTMSTLFATQIMNSNHAKASVTESVDKKFVVPESGINKIIPAYDEFKNSPKVNVSNLTDNKNFVASEDKLNKIADSSAASKIVDKNFVVPESKLGNIVPEYKEINNRVNVATNNPASQQVDKHFVAKGPEVNRFITQNKVNHHFITTQTHYKKVITSYKSTHVHKHVNHAKDSINKHFIVKPSESPRYTHPSQSLIIKHHFAVPGYHAHKFVTPGHASIKINHFCVVPQINSFKVIPPYGHNSHRMHVPSFQNNTTATHQNAKVNKAYDYKYFYSYKVVKGVKKYFSFSQSNGYKIGKPSLNIKNVNYQYAVPSYSPTHYVPEFKGSLPAPRV
What is the function of this protein?
Adhesin that binds to the host cell extracellular matrix proteins fibronectin, fibrinogen, collagen, and vitronectin.
What are the official names of this protein?
Extracellular matrix protein-binding protein emp.
What are the subcellular locations of this protein?
Cell surface.
Protein: FDXH_HAEIN
Sequence: MAGTAQGVQTQDVIKISATSGLTPAPQARDHKVEIAKLIDVSTCIGCKACQVGCSEWNDIRSDINAQCVGVYDNPVDLDAKAWTVMRFNEVEENDRLEWLIRKDGCMHCTEPGCLKACPAPGAIIQYANGIVDFQSDKCIGCGYCIAGCPFNIPRMNPEDNRVYKCTLCVDRVSVGQEPACVKTCPTGAIRFGSKEEMKIYAEQRVADLKSRGYENAGLYDPPGVGGTHVMYVLHHADKPELYNGLPKDPQIDLSVTLWKDVLKPVAAVAMGGLALAEVAHYLTVGPNVEEDVEDHHHEFEENKPSKGENNE
What is the function of this protein?
Allows to use formate as major electron donor during aerobic respiration.  The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.  Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity).
What are the official names of this protein?
Formate dehydrogenase iron-sulfur subunit, Formate dehydrogenase subunit beta, FDH subunit beta.
What are the subcellular locations of this protein?
Cell membrane.
Protein: NUOK_AKKM8
Sequence: MIPLTHYLILSGVLFAIGLMGVIVRRDIIVIFMCLEMMLSAANLSLVAFSRAQGTMGLPNYDGQALSIFILTIAAAEVAIGLALIVSLYRARRTASTQDLNTLKD
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PKR1_YEAST
Sequence: MANFFVRLWESVFEPGTSPQLIIATHVSFVALLLTLIWLIYATNGNIHFYALFCISLLLWITVIWFINELSHVKLKDNDELDKDANKKDDSAIKEDSEDKQESGKSTSTARRTQAQSRSRKA
What is the function of this protein?
Functions together with the other V-type ATPase assembly factors in the endoplasmic reticulum to efficiently assemble the V-type ATPase membrane sector V(0).
What are the official names of this protein?
V-type ATPase assembly factor PKR1.
What is the protein family that this protein belongs to?
Belongs to the PKR1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CDIB2_BURP2
Sequence: MATRFAILPVTALITLTAQAQQAPTPNDQAAAARANAEQNQQAQQRRDAQQRDATVQAPGVRSDVPRPEAYPVLPTETPCFQIDRFALDVPDSLPAASKAQGASALPMDRFAFARDWLAHYAGQCIGKQGVDLIVKGLSQAILARGYITTRVLVPEQDLSTGALKLALIPGVIRHVRFEDEKLLGTWKTAFPTRDGDVLNLRDIEQGLEQMKRVSSQDVSMRIAPGDMPGESDVVLDVKRGKPWTVVASIDNSGTRATGKLQGNVSLGIDNPLGLNDIFNVGFNQDLEFGDKRFGSHGWNAFYSIPWGYWTGTLSAYTSTYFQPLAAVNQTFVASGNMKTVDFRLNRVLTRSRNDVLGAQVRLTRRFGDSYIEGTTIPSSHQNATFLEFGLNDRHYFGSSQFDGSLAYRQGLGWLGSTDSMFAAEGGQTYRFKMVVLDANLSTPFVIGTQPFKYVTTFHGQYTGNTVSYLDSVTIGSRYTVRGFDGETLLAGSRGFYWRNELQVPVAQTGLSAYAGLDYGRVWGPEPVALVGTQLAGAVIGVKGSLMTRFGGYGYDLFAGTPVYKPSGFPTARVTVGFQLTAQF
What is the function of this protein?
Probable member of a two partner secretion pathway (TPS) in which it mediates the secretion of CdiA2.
What are the official names of this protein?
Outer membrane transporter CdiB-2, CdiB-2, CdiB-II.
What is the protein family that this protein belongs to?
Belongs to the TPS (TC 1.B.20) family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: PHS_BRUO2
Sequence: MARNRLTESEMNEALRALDGWQKVDGREAITRSFKFKDFSTAFGFMAQAALYAEKLDHHPEWFNAYNRVDVTLATHSENGVTELDIKMARKMNAIAG
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: RS17_PIG
Sequence: MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGAV
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: HHEX_MOUSE
Sequence: MQFPHPGPAAAPAVGVPLYAPTPLLQPAHPTPFYIDDILGRGPAAPTPTPTLPSPNSSFTSLVSSYRTPVYEPTPVHPAFSHHPAAALAAAYGPSGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTVELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKDALDSLDTSCEQGQDLPSEQNKGASLDRSQCSPSPASQEDPDSEISEDSDQEVDIEGDKGYFNAG
What is the function of this protein?
Recognizes the DNA sequence 5'-ATTAA-3' (PubMed:10804173).  Transcriptional repressor (PubMed:10804173).  Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:16936074).  Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (PubMed:16936074).  May play a role in hematopoietic differentiation (PubMed:8096636).
What are the official names of this protein?
Hematopoietically-expressed homeobox protein Hhex, Homeobox protein HEX, mHex, Homeobox protein PRH.
What are the subcellular locations of this protein?
Nucleus.
Protein: ABHD1_RAT
Sequence: MEYLHITKMLSSSLSPQNGTWSDAISLLLALGIALYLGYYWACVPQRPRLVAGPQFLAFLEQHCPVTVETFYPTLWCFEGRLQTIFRVLLQSQPVIPYRSEVLQTPDGGQFLLDWAEQPYSSHCPDPTTQPIVLLLPGISGSSQEPYILHLVDQALKDGYRAVVFNNRGCRGEELLTHRAYCASNTEDLETVVKHIKHRYSRAPLLAVGISFGGILVLNYLARTGKAGGLVAGLTMSACWDSFETVDSLETPLNSLLFNQPLTAGLCRLVARNRKSIEKVLDVDFAIKARTIRQLDERYTSVAFGYKDCAAYYHASSPRTKVDAICTPVLCLNAADDPFSPVQALPLQAAQKSPYVALLITARGGHIGFLEGLLPWQHCYMNRVLHQYARAVFQHSVGLPGLGALTPEDGKS
What are the official names of this protein?
Protein ABHD1, Alpha/beta hydrolase domain-containing protein 1, Abhydrolase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: ATPL_ERWT9
Sequence: MENLNMDLLYMAAAVMMGLAAIGAAIGIGILGGKFLEGAARQPDLIPLLRTQFFVVMGLVDAIPMIAVGLGLYVMFAVAK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURC_AGRVS
Sequence: MKMPKSIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQAESANVQRLRAKGIEVFVGHKPENLGDAEVVVVSTAIKKSNPELVAAREKLLPVVRRAEMLAELMRFRNAIAIGGTHGKTTTTSMVAALLEAGQLDPTVINGGIINAYGTNARMGEGEWMVVEADESDGTFLKLPADVAVVTNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVGRIEDRKVVTYGENPQADVRFFNVRNEGTKSIFDVEIRRRRTGRVFSFKDLTLPMPGRHNISNACAAIAVANRLDISEEAIRKGLSTFGGVKRRFTLTGTWNGVQVFDDYGHHPVEIKAVLKAARESCKGRIIAVHQPHRFSRLSSLFEDFANCFNDADSILLSPVYAAGEDPIEGIDSEALVSRIRSGGHRDVRYLASPDQLAGIISTIAQPGDFVVLLGAGNITQWAAALPSELQALSGKSE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAV1_CALJA
Sequence: MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYIHTVCDPLFEAIGKIFSNVRISLQKEI
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.  Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity).  Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).  Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).  Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).  Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Caveolin-1.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: HYPA_HYPLI
Sequence: MLKFVILLCSIAYVFGAVVPLGMLSQSDGRIVGGVESKIEDFPWQISLQRDGRHYCGGSIYSKNVIITAAHCLRNVVAEELRVRVGSSYWEHGGSLRNISKFQIHESYVEPTKEYDVALLKLDSDLSFNSTIKAIELTNEIPPEYADAIVSGWGETLVPPPGIPDQLRSVDVKIIHREKCASRNFGYGSNIKASMICAYAIGKDSCQGDSGGPLVVNNLLVGVVSWGIDCARPSYPGVYVDVSHVRSLIVSNAESI
What is the function of this protein?
Specificity, limited to carboxyl side of arginine residue in B-chain of insulin.
What are the official names of this protein?
Hypodermin-A, HA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAK_WOLPP
Sequence: MGRAIGIDLGTTNSCVAIMQGKDAKVIENKEGARTTPSIVAFTSSGERLIGAPAKRQATTNANNTFFATKRLIGRQYSDPEMKNLGVPYKVFAAKNGDAWVKTTDGKEYSPSQIGAFILQNLKEAAEAYLGEEVKDAVITVPAYFNDSQRQATKDAGKIAGLNVLRIINEPTAAALAYGLDKKHGHTIVVYDLGGGTFDVSVLEIGDGVFEVKATNGDTHLGGEDFDNAVVNYLLGEFKKSNGIDLKNDPMAMQRIKEAAEKAKVELSSAMETEVNLPFVTVDASGPKHLNIKLTRAKLESLVNDLIERTIIPCKKALEDAGLSASQIGEVVLVGGMTRMPKVIEKVKEFFGKDPHRGVNPDEVVAIGAAIQAGIIQGDVRDVLLLDVTPLSLGIETLGGVFTPLIERNTTIPTKKSQVFSTAEDNQTAVTIKVHQGERKLAIDNKLLGQFSLEGIPPAPRGVPQIEVTFDIDANGIAHVSAKDKATGKEQKIRIQSSGGLSEDEINRMVREAEEKAQEDEKRKKFIEVKNQADSLVHSTEKSLTEYGDKISPEDKSAIENAVNELKEVSKSDNIDDADSIQQKVTNLSQLSMKLGEAMYKESQQQQGGESSSTTNNEEEKVVDSDYQDMDNKEENK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: HXA6_MOUSE
Sequence: MSSYFVNPTFPGSLPSGQDSFLGQLPLYPAGYDALRPFPASYGASSLPDKTYTSPCFYQQSNSVLACNRASYEYGASCFYSDKDLSGASPSGNNKQRGPGDYLHFSPEQQYKPDGSVQGKALHEEGTDRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQASGEDSEAKAGE
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A6, Homeobox protein Hox-1.2, Homeobox protein M5-4.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: URK_BACP2
Sequence: MRSKPVVIGIAGGSGSGKTSVTNSIYEKFKGHSILMLQQDLYYKNQSHMPFEECLLTNYDHPLAFDNDLMFEHLEQLLRYESIEKPIYDFKLNTRSEETVHVEPKDVIIVEGIFALEDERLRDLMDIKLYVDTDADLRIIRRILRDTKERGRSIDSVIEQYVSVVRPMHNQFIEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILQSRAE
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.