PharMolix/UniProtQA huggingface dataset:
Protein: YR402_MIMIV
Sequence: MSSNNDNSTNNKNNVNINTDNRLYQLDELISDIYKAVYIKDNDYTIKFIDVKDINLPRFKLSDYDLDIIFDKIKYAGSFPTGIVIDGTSTNEIWFKRRGETEMSTIRIVPYQNKEAVDDITDPINVNQIMKTLLSELVVSEKTNNILLPVINVDVLGSDLTTYGKISPYINSSDDTYYSVQVTEKYYSLKTLDQFFKDYVIEARTIKSIIYQAIDVLYQISVQYPKFKYNQLFPETIDCYLKQDNNLIIPEIKLSNFYLSSIDDLVKNSYLDSNDFTVEQIADQYGDLYQLVNYMWNNLQSSIQNFPDVIKIFDIVLPKKIRSKELYLTSELWNLLSEDEKFELKIKNLRNNHIFTSKDSLSNTTFVKSKDQPIDFSGGSEDNELSVEDFEASEDLNDIDESIPVVKNSSKIKYPHKDIGIMANNKTISDRKLTDNLSNKSSNDNTSETTSDKSYRSSNSRNSDNSKSKTTRSKTQSSDSSKSSRIPRSSESKRSTNSVVSVGSTGSDVYSDMERTEYPSRSTYKSRTINRSDSESSPVSSRTSSPVDDSRLKQSRISEDKPRKNKAYRGRRVIGQNNTASLLAALNDDNYNQGQNNVTDINSIGSMLGVSVNELASKNSNPNYSQIMQQIASQMNGQQASPNSLFGQAGNINQQLNPQQLSALLGQSYNPNTQFNQLNQLGQLGQLNSMNSINQMAQLGQMGQLGQTGQVNPMSQMSQMNTMNPMGQPNQSYNSQNDTDLLYRYMATLNQGQSGQQMDPNAIATLMQQNSTGFPSYAQLGGNVNNNNNMNRNPFFFQ
What are the official names of this protein?
Uncharacterized protein R402.
What are the subcellular locations of this protein?
Virion.
Protein: RRF_CROS5
Sequence: MMLDDLKENMQKSVEATQRSFNTIRTGRANASILDRVTVEYYGTETPLYQLANISTPDATTIMIQPYDKGSMGQIEKAIQMSDVGLTPNNDGQVIRLNIPPLTEERRKDLVKLASKMAEEGKVAIRNIRRDAIDDVRKQEKNSDISEDESRGLQDDIQKVTDQFTDKIDELLAAKEKDIMTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLA4_ASHGO
Sequence: MSLSAAARELSESDFQDIGPAPKPPPVAYNQTKPLVNYMSQMDLGAKSGGKMRAVQRKKSGWVSYKDDGLLSFLWQKRYMVLNDNYLSLYKGDSGREDAVVQIPLTSIVSVSRNQLKQNCFEVVRSSDRSGAPAAGAGGDSSKKSVFIATKTELDLHTWLDSIFSKCPLLSGVSSPTNFTHKVHVGFDPETGSFVGMPFNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEYNNGTATPTAQAAAQAAGAPGRPPMLTLSSNSSQASMQQIASTPPYSGGEMIPQRKAPTPPKPVVTSGSAIPSAKGGPNVGVTTSPSVHHQNTQHGKQQSPTQSGPPKSLPPLHRDEEGPTAPLGNSVSSVATKESPTERLLNNLSETSLMQKQLPAKPVAPPSSVGPVAPPLRLQPQRVAPGRPAQPGPHAPDTRPGGPNAMKQQHGPPAAASGQLGPDSKKPEGAPGHPTAVAKKKKAGRPTMSNAEIMTRLAAVTFNTDPSPFFQMIEKAGQGASGSVYLAQRLKIPPYDENSGVSQHELNDNIGDKVAIKQMILSKQPRKELIVNEILVMKDSQHKNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDVIENSIGSDASESPMTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTHGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLEGEPPYLNEEPLKALYLIATNGTPKLKHPELLSLEIKRFLSVCLCVDVRYRASTEELLHHSFFETSCEPEELANLLKWKK
What is the function of this protein?
Required for hyphal maturation and for septation.
What are the official names of this protein?
Serine/threonine-protein kinase CLA4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Protein: KUP_BRUAB
Sequence: MSGELNGNDTSAQAAVSAGSVLEGAAFADEGEQHNESMKTLVLGALGVVYGDIGTSPIYAFREALHAAATNGILARSDILGVVSLIFWALTLVVTVKYVLFVLRADNNGEGGILSLMALVRGALKGRPDLILGVGICGAALFFGDAVITPAISVLSAMEGLEIVAPNLTPFVVPAAVVILVTLFSVQKLGTGRVAIVFGPIMALWFVALGASGLWHIFDDPTVMAALNPYYAVRFLTVSPAVAFVTVGAVFLAMTGAEALYADLGHFGRKPIVRAWLWIVFPCLLLNYFGQAAFILSHGEAAALPFFQMIPSFALWPMVLLATAATVIASQAVITGAYSVARQAVQLNILPRLEIQHTSEKLHGQIYIPRVNLLLGLAVVILVLGFEKSSNLAAAYGIAVTGNMLVTTVLLYIAMTRIWNWRVSRALPIILGFLVIDMLFFSANIIKVHEGGWASIGIATVLVLIMWTWVRGTRHLFQKTRKAEVPLDLIVEQMAKRPPTIVPGTAVFLTGDPKSAPTALMHSLKHYKVLHENNVILTVVTASKPWVASADRARVSQYNERFMLVTLTFGYMQQPNIPRALGLCRRLGWKFDIMTTSFFLSRRSLKASVHSGMPLWQDKLFILLARTASDATEYFQIPTGRVVEIGTQVNI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UPP_SINFN
Sequence: MDGVTVIDHPLVQHKLTIMRKKETSTAGFRRLLREISTLLCYEVTRDLELTMERIETPLQEIDAPILEGKKLVFASILRAGNGLLEGMLELVPSARVSHIGVYRDHETLQPVEYYFKAPDSLNERLVIVVDPMLATGNSSIAAIDKLKERGAKNIRFLCLLAAPEGIRNFHGVHPDVPIFTASIDSHLNEKGYIVPGLGDAGDRMYGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: SP2R_BACSU
Sequence: MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIRLRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKETMEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLCFLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEWISDLFS
What are the official names of this protein?
Stage II sporulation protein R.
Protein: SSXT_MOUSE
Sequence: MSVAFAAPRQRGKGEITPAAIQKMLDENNHLIQCIMDYQNKGKASECSQYQQILHTNLVYLATIADSNQNMQSLLPAPPTQTMPMGPGGMSQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPSQLSMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMNMQPNQGPMMHQQPPSQQYNMPPGGAQHYQGQQAPMGLMGQVNQGSHMMGQRQMPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQSYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQGQYGNYQQ
What is the function of this protein?
Appears to function synergistically with RBM14 as a transcriptional coactivator.  Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.
What are the official names of this protein?
Protein SSXT, Protein SYT, Synovial sarcoma-associated Ss18-alpha.
What is the protein family that this protein belongs to?
Belongs to the SS18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TX32D_CYRHA
Sequence: MKLCAVIIASLLVCVAVASSSDNQKEFAQEKEMTREETQSLGEHEKDDEVTGSEERSCIEEWKTCENDCECCGMSTLCAASWVDGHEIKLCRNEGGKLKKVLHFIQKSVSKIRSCKK
What is the function of this protein?
Putative ion channel inhibitor.
What are the official names of this protein?
Hainantoxin-XV-3, HNTX-XV-3.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 03 (Tx2) family. 02 subfamily. HNTX-XV sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YCBK_ECO57
Sequence: MDKFDANRRKLLALGGVALGAAILPTPAFATLSTPRPRILTLNNLHTGESIKAEFFDGRGYIQEELAKLNHFFRDYRANKIKSIDPGLFDQLYRLQGLLGTRKPVQLISGYRSIDTNNELRARSRGVAKKSYHTKGQAMDFHIEGIALSNIRKAALSMRAGGVGYYPRSNFVHIDTGPARHW
What are the official names of this protein?
Uncharacterized protein YcbK.
What is the protein family that this protein belongs to?
To H.influenzae HI_1666.
Protein: RPOC_YERPB
Sequence: MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERRQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKNMDLEAECEILREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERIYRAGLASLHARVKVRITEEIRNTEGESITRTSIIDTTVGRAILWMIVPQGLPYSIVNQPLGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEAKAGIIEEAETEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMDNLSVEDVVNRDGVVEQQVSFNSIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHNGIVMTPVIEGGDVKEPLRDRVLGRVTAEEVIKPGSADILVPRNTLLDEKWCDLLEENSVDSVKVRSVVSCETDFGVCANCYGRDLARGHIINKGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSLKLSNVKFVTNAAGKLVITSRNTELKLIDEFGRTKESYKVPYGAVMAKGDGAEVQGGETVANWDPHIMPVVTEVSGFIRFADMVDGQTITRQTDELTGLSSLVVLDSAERTGSGKDLRPALKIVDAKGNDVLIPGTDMPAQYFLPGKAIVQLEDGIQIGAGDTLARIPQESSGTKDITGGLPRVADLFEARRPKEPAILAEISGIISFGKETKGKRRLVISPLDGSDAYEEMIPKWRQLNVFEGEVVERGDVVSDGPESPHDILRLRGVHAVTRYITNEVQEVYRLQGVKINDKHIEVIVRQMLRKGTIVDAGSTDFLEGEQAEMSRVKIANRKLAAEGKIEATFTRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRKAQGEAPVVPQVSADEATANLAELLNAGFGNNKG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: FTMH_ASPFM
Sequence: MTIPTEISCPEEDAFQLLDKFSWFPSDDQRRWWEYTGPYLLKLLRDAKYPQKDQVPCLYLLQQLLVPYLGTFPVVGQAPLPWWSNVTTYGVPFELSWNLLHNIVRIGFEPLSHLAESGVDAFNKTAPEECVSRLACLDNTIDLARFRHFQHHLLVTPEEETWLLREKAPLPKSGRGQQTLAVEFQNGGISAKAYFFPGMKSLATGLSPGKLILDSIERLALPGLKEPVHHLRSTLGLQDDGHPTDTAIAPFLLGVDLCTPERSRLKFYVTDQVVSWDRVADMWTLRGKRLEDPQCADGLALLRKLWDLLAIPEGYRSNIRPDFAFGTPPPEDYRPVMMANWTLSPKKKFPDPQIYLLTVGMNDAVVMDALVAFYEVLGWTDLASTYKDKVASYFPGPDFTKTNYIHSGVSFSYRHSKPYLSVYYSPF
What is the function of this protein?
12-alpha,13-alpha-dihydroxyfumitremorgin C prenyltransferase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities (PubMed:18683158, PubMed:23649274).  The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA (PubMed:16755625).  Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B (PubMed:16000710, PubMed:21105662, PubMed:23090579).  The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively (PubMed:19226505).  The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable).  FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B (PubMed:18683158).  Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties (PubMed:19763315).  In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
What are the official names of this protein?
12-alpha,13-alpha-dihydroxyfumitremorgin C prenyltransferase, Fumitremorgin biosynthesis protein H.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: CH10_BUCMP
Sequence: MKIRPLHDRVLVKRQEVESKSAGGIVLTGSAAGKSTRGTVTAIGKGRVLDNGQIKPLDVKVGDTVIFNEGYGAKTEKINTEELLLLTESDILAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SH2D3_MOUSE
Sequence: MTEMPKKTGRKFKFFKFKGLGSLSNLPRSFSLRRSSASASIRSCPEPDTFEATQDDMVTLPKSPPAYARSSDMYSHMGTMPRPNIKKAQKQQAVQKAQEVSRESHLVSRRLPEPPDLEAAKEAGEGTEALLEDTAPSAVEVDPMRELEDLTVDTEKEQVPGDVSPERTAAELEAAGDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWHNQALHFKINKVVVKAGESYTHIRYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLSQGSSKTASPASPSGSKGSHMKRRSITMTDGLTTDKVTRSDGCPNSTSLPHPRDSIRNCALSMDQIPDLHSPLSPISESPSSPAYSTVTRVHAPSATPSTSAQPASPVARRSSEPQLCPGNTPKPPGESDRAPHASPSHTLCKASPSPSLSSYSDPDSGHYCQLQPPVRGSREQAAGETPRKARGSGERQKELLENGVSDGEWGKTFTVPVVEATSSFNLATFQSQLIPKENRPLEVALLRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALEMAQISRLEQTWMTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPFITLLECDSAPAEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGANSSQAWRYEKFDKVLTALSHKLEPAIRSSEL
What is the function of this protein?
May be involved in the BCAR1/CAS-mediated JNK activation pathway.
What are the official names of this protein?
SH2 domain-containing protein 3C, Cas/HEF1-associated signal transducer, SH2 domain-containing Eph receptor-binding protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, ruffle membrane. Note=Associated with the membrane when EGF-stimulated (PubMed:10692442). Expressed at the cortical actin ring in B cells (PubMed:20956287). SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Peripheral membrane protein.
Protein: CPXT2_MICAN
Sequence: MTPELITFGRYLAGEFENQRQAQAEPVWYVHLRLWLRPLPLFREDSIALFAEQASIINLDQPYRPRLWRLTHSESGGLEVRHYMFNDLKSVQGAGKNPDILRKISLEDLTFLPTCTLAVKVNTLADNQYQFIAQPQPEQRCQFTYEGTTYQVALGFEVTSHSLKTYDKGLDPGTGKGIWGALLGPYQYEKKRDFSAELDV
What is the function of this protein?
Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.
What are the official names of this protein?
Chromophore lyase CpcT/CpeT 2.
What is the protein family that this protein belongs to?
Belongs to the CpcT/CpeT biliprotein lyase family.
Protein: PROB_HERA2
Sequence: MDRDLHMRIVVKLGTSVLTDGTDRLHRPRMVDLARQMAQLREAGHEVVLVSSGAVLAGWERLGFPKRRRELTHKQALAAVGQGRLMHIYGQLFEIYDVPVAQTLLTRADLRDRVRYLNARATLLTCLEIGVLPIINENDAVAVDEIRVGDNDTLSALVANLVDAQLLVILSDIAGLYSADPRHNPEATLIDDVAAVNEQVYALAGAAGSHRGTGGMFTKIQAAELATRAGTTMVIAAGNEPNVLVRLVAGESVGTRFRPVSTRLESRKRWIMAERVRQAHIAVDAGAVQALTQQGRSLLPAGIVAVEGEWRRGQTVAIVAPDGQTIACGLCQYAAHEVAQIKGSRTSDIESILGYSYGAEVIHRDDMVAF
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FCTA_ECOLI
Sequence: MSTPLQGIKVLDFTGVQSGPSCTQMLAWFGADVIKIERPGVGDVTRHQLRDIPDIDALYFTMLNSNKRSIELNTKTAEGKEVMEKLIREADILVENFHPGAIDHMGFTWEHIQEINPRLIFGSIKGFDECSPYVNVKAYENVAQAAGGAASTTGFWDGPPLVSAAALGDSNTGMHLLIGLLAALLHREKTGRGQRVTMSMQDAVLNLCRVKLRDQQRLDKLGYLEEYPQYPNGTFGDAVPRGGNAGGGGQPGWILKCKGWETDPNAYIYFTIQEQNWENTCKAIGKPEWITDPAYSTAHARQPHIFDIFAEIEKYTVTIDKHEAVAYLTQFDIPCAPVLSMKEISLDPSLRQSGSVVEVEQPLRGKYLTVGCPMKFSAFTPDIKAAPLLGEHTAAVLQELGYSDDEIAAMKQNHAI
What is the function of this protein?
Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR).  Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate.  It can also use succinate as an acceptor.
What are the official names of this protein?
Formyl-CoA:oxalate CoA-transferase, FCOCT, Formyl-coenzyme A transferase, Formyl-CoA transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. Frc subfamily.
Protein: DNAK_DESDA
Sequence: MSKIIGIDLGTTNSCVYVMEGKDPKCITNPEGGRTTPSVVAFTDKERLVGEIAKRQAVTNPTRTIFAIKRLMGRKFDSPEVDRWKEHSPYAIVKAPNGDAGVEVDGRTYSSPEISAMILAKLKADAEAYLGETVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAASLAYGADKKANEKIAVFDLGGGTFDISILEVGDNVVEVRATNGDTFLGGEDFDQRVINFLVEEFKKENGIDLSKDSMALQRLKEAAEKAKKDLSTSMETEVNLPFITADQNGPKHMLVKISRAKLESLVGDLVESTTEPCKKALADAGMTADQIDEVILVGGMTRMPLVQQVVGKFFGKEPNRSVNPDEVVAMGAAIQGGILSGDVKDVLLLDVTPLSLGIETMGGVFTRLIERNTTIPTRKSQVFTTASDNQPSVSIHVLQGERPMSADNMTLARFDLAGIPPAPRGVPQIEVSFDIDANGIVNVSAKDMGTGKEQSIKITASSGLSEEDIQKLVREAEAHATDDKKKQELIEARNHADSLIYGTEKSLADLGDKADAAVKSDIETKMADLRKLMEGEDAAAIKTATDELAKASHKLAEQLYQQQAQQTGAAGAQADAGAAEGQPQGNAADDVVDADYTEVKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: JAK1_HUMAN
Sequence: MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
What is the function of this protein?
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:8232552, PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216).  Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).  Kinase partner for the type I interferon receptor IFNAR2 (PubMed:8232552, PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216).  In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950).  Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:8232552, PubMed:16239216, PubMed:32750333).
What are the official names of this protein?
Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Protein: HPSE_MOUSE
Sequence: MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEPTSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRSSVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEPNSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHNVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSLPAFSYGFFVIRNAKIAACI
What is the function of this protein?
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.  Participates in extracellular matrix (ECM) degradation and remodeling.  Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group.  Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety.  It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes.  Facilitates cell migration associated with metastasis, wound healing and inflammation.  Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas.  Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII.  Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity.  Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion.  Heparin increases this AKT1/PKB activation.  Regulates osteogenesis.  Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF.  Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
What are the official names of this protein?
Heparanase, Endo-glucoronidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 79 family.
What are the subcellular locations of this protein?
Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Associates with lipid rafts.
Protein: EIF3K_BOTFB
Sequence: MGVPFDYAPDRPEHIDAILNGLDRYNPETTNIFQEYVTLQCEEKTYDCYANLALLKLYQFNPHLTKDETITNILVKSLTVFPSPDFSLALHLLPPHILTPISASSSLPAAGDAPLSEAVQKLAVLNTLLSSANYSQFWSTLDSDDLYADLIADVSGFEELVRIRIASTISQSVREVASSELENWLGMNGEAFEKFIKEVCGWTIENGVVIVPLNKENEAKGTVVRENVKMEQFSRVIKRAYEQPA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit K, eIF3k, eIF-3 p25.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit K family.
What are the subcellular locations of this protein?
Cytoplasm.