PharMolix/UniProtQA huggingface dataset:
Protein: MUTS_EHRCJ
Sequence: MNHDRKITPIMQQYMMLKNQYKECLLFYRLGDFYELFFDDAIETSKVLNIVLTKKGNVPMCGVPFHSSESYLNRLVKLGYKVAICEQLETPEEAKKRGYKALVKRDVVRIVTPGTILEDSLLEAKENNYLCCIVNVNDNYAIAWLELSTGLFHYNTTDLRKIDSDLLRINPKEVLISDKLVELDLIYSTLKKYKFSITQYSSSFFDTSRSYNTLCSVYGISTLKGLGDLKDEEIAVCGSLLEYVKATQKGNLPKLEFPKAYGDRDFMFIDAAALRNLELFNTQSGDLEGSLISSIDYTITACGGRLLKRCLSAPLACSYAINRRLDIVEFFVNNKVLYKNVRETLRGIADIERILTRVKVGRCSPKDLYALKLTLDKTCILVNLLSKFDTSVVSDFCTRLGRYDDLCKTLSNVLIPNNVSNVKDGGFIKPDYDVQLSEYIYIQNYSNNLIQELRDKYRNITNIQNLKILYNNILGYYVEVSANHLINDKDFIHRQTLANSIRYTTSELKALESKIISARDAAISLEVKIFGQLCTRIIEHADEITMTAHAVSEIDMLTSFAELAIQYSYTRPVVDDSYEFNIQKGRHPVVERNGKFVANDIDLAQMQRVHLITGPNMAGKSTFLRQNALIGILAHIGSFVPAYSAHIGVIDKIFSRVGASDNIAFGYSTFMVEMTETAAIINQATDKSFVILDEIGRGTGTYDGLSIAWSVIEQIHNVNKSRAIFATHYHELSKLDECLENIKCFCMKVEEWNGKVVFLHEIIPGSTNKSYGIHVAKLAGFPQSVLDRAEDLMNKLKANEDLLT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RMXL3_PANTR
Sequence: MMEADRPEKLFVGGLNLKTDEKALKAEFGKYGHIIKVFLIKDRKTNKSRGFAFVTFESPADAKAAARDMNGKYLDGKAIMVAQTIKPAFESSRWVPPTPGSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYVGYFDLWPYRAPMPRKRGPPPRHCASPPHKRRDPGDFVPALREYSRRYYGHSSVPDYCPXRGDGNRNGYRGRDHDYMDHPSKGSYREPLKSYGGPCGAAPVRGTPPSYGGGCCYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHLPKAYSGGRSSSSNSYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRYEEYRGRSHEARSGGRSTDAHSGGRSDNAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGRSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGRSSSSNSYGQSHRYGGEGHYEYRGRSHDAHSGGCSADAYSGGHDSSSRSHRYRGGGRYVEYRGRSLDANSGGCWPDAYSGGHDSSSQSYRYRGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSRSHRYGGGGCYEEYRGRSLDANSGGRWPDAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGCSPNAYSGGHDSSSQSHRYGGGGRSLDANSGGRSPDAYSGGHDSSSQSNRYGGGSRYEEYRGRSLDANSSGRLPDAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGQSPDAHSGDRSTEAYSRGRNSFSNSYGQSDHYGRGGRYEEYQGRSPDAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGHDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGQSRY
What are the official names of this protein?
RNA-binding motif protein, X-linked-like-3.
Protein: MTNB_CANAL
Sequence: MSAPCHCKHVDDSSSNDKLSALSPELQQEFKDPNHPANLICELCRLFYDNNWVTGTGGGISIRDVDGPNPNLVYIAPSGVQKERIQPWEMFLVELPDEKILRTPNDIPKELTKSYKYKPSACTPLFISCYTLRDAGACIHTHSQHAVMVTLFFENEKEFAISHIEQIKALPKLKYNDETGKIEKIGSMEYYDKLVIPIIENTPHEEDLTDSLQEAIKNYPGASAVLVRRHGIYVWGETVWKAKVYNEAIDYLLELAVKMKLAGIPLVKQE
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_DEIRA
Sequence: MTNQKQETKLWGGRFAEKTAELVELFNASVGFDQRLAEQDIRGSLAHVAMLGGQGILTAEEVSQITDGLNGVLADIRAGNFEWRLDREDVHMNVEAALRDRIGPVAGKLHTARSRNDQVAVDFRLFTKEAALDLAEQTRALRRVMLAEAEKHLQNEVILPGYTHLQVAQPILLAHWFMAYVAMLERDEGRFRDAAERMDESPLGSSALAGTPWPLDRHATAEALGFARPTANSLDGVGSRDFALEFLSACAILSAHLSRLSEELILYSTFEFGFITLPDSHTTGSSIMPQKKNPDVSELARGKAGRVFGNLMALLTVVKGTPLAYNKDLQEDKEGVFDSYDTLSIVLRLYAEMLPKTVWHADVTKAAAARGYSTATDVADYLARQGVPFREAHEVVGGLVGLASRSDRQLWELTDAELKAAHPLLSAEVAQKLTVEESVRSRQSYGGTAPERVREAVEAAKEKLRQETGQP
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_BURP1
Sequence: MFSVGLTGGIGSGKTTVADLFGKLGATIVDTDLIAHRITAPQGLAMPLIAREFGAEFVAADGSLDRAKMRALVFSDESARKRLEAITHPLIREETEREARTAQGAYVVFVVPLLVESGTWKTRVDRVLVVDCDVETQIARVTARNGFTRAQVEAIVARQASRDARLAAADDVIANDNASVAELAAEVAALHQRYLECAAAARN
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODAIF_SARBU
Sequence: NKLKPSQWISL
What is the function of this protein?
Substrate for angiotensin converting enzyme (ACE) in vitro.
What are the official names of this protein?
Ovary-derived ACE interactive factor, Neb-ODAIF.
What is the protein family that this protein belongs to?
To the N-terminal part of insect vitellogenins.
Protein: CMR1_KLULA
Sequence: MGELTEFQKKRLENIKRNNDLLKKLNLNNVSSQIKREAGVEDEHLDRKRKKKAGSAKKAVKKEPKPAAIPTRRSRRLRGENVDGNGIPNVNDNQLLKMGQSDSTPELEAIDELKNTALSGDVKLSDLIKSENEEELLDKFKSFANKNFSSGDFFKELQQQQVPTPEIKQLQEDFDLKLYDIFQPNEIKLTAERISATFFHPSVDKKLVICGDTAGNVGLWNVRETQPEDELEEPDITKVKLFTKNVGRIDTYATDSSRLLAASYDGYLRSINLQDMNSEEILVLKNEYDDPLGISDFQFNYNDPNVLFMTTLSGEFTTFDVRTKPTEINLKRLSDKKIGSFSINPKRPYEIATGSLDRTLKIWDTRKIVNKPEWSQYEDFASHEIVATYDSRLSVSAVSYSPMDETLVCNGYDDTIRLFDVSGTLPEDLQPKLTLKHNCQTGRWTSILKARFKLNMDVFAIANMKRAIDIYTSSGVQLAHLPTATVPAVISWHPTQNWVVGGNSSGKAFLFT
What is the function of this protein?
DNA-binding protein that binds to both single- and double-stranded DNA.  Binds preferentially to UV-damaged DNA.  May be involved in DNA-metabolic processes.
What are the official names of this protein?
DNA damage-binding protein CMR1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DDB2/WDR76 family.
Protein: BDNF_SANME
Sequence: PMKEVSIRGQGSLAYPGLRTQGNLETLSGPNDATRGLTSLADTFEHVIEELLDEQQVIQPSKENKDADLYSSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCSSKGYAKEGCRGIDKRYWNSQCRTTQSYVRALTMDNKKRVGWRFIRIDTSC
What is the function of this protein?
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARP2_XENTR
Sequence: MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPVIRSTAKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRDCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRVIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRPEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGTRVLEKLGVTVR
What is the function of this protein?
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity).  Seems to contact the pointed end of the daughter actin filament (By similarity).  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
What are the official names of this protein?
Actin-related protein 2, Actin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Protein: ARGB_PROM5
Sequence: MDDSLRVSILSEALPYIQSFSGRKIVVKYGGSIMEDEKLKKAFFRDIALLSSVGVCPVVIHGGGPEINRWLSKLEISPKFEKGLRVTDDKTMEIVEMVLMGRVNKQIVRGINKTGSLAVGISGLDGNLIQSRELGDGSHGLVGEVTQINPELLEPLIAKGYIPVISSIGSTTDGISHNINADFVAGELAAAINAEKLILLTDTPGILKERNNPNSLAKQINLKEARKFIEKNIVSNGMLPKTECCIRALAQGVRAAHIIDGRIEHSLLLEIFTNSGIGTMINA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUR5_CAEEL
Sequence: MTAVSANGKTTEKHENGAHTNGTTNGTTNGSMNGNEISHVQKLQPVYYKPPQNLETFELSLRNHFEEKTNKKFADYREFHRFTCDNYGIFWEDLLKLSDVKLHQNYNQVIDHNLKINERPRWFNGATLNYTENVIERGTATDIAVLNASIEETVTEYTYDNLRKDVYRIATSLRNYGIGPGDTVCGFVPNTYDTLVAVFATAAVGAAWCSASVDFGPAGVLDRFRQVHPKVLFTVNHVTYKKKLIDQTDKINEIVKELPTLEKIVVSDTFTSVKFDATKYNQSDKFSSLEEFKTPIADVVLPFVYTPVPFSDPLFVMFSSGTTGIPKAMVHTVGGTLLKHIEEHLVQGDSKKHDRMFFYTTCGWMMYNWMISFLYSKGSVVLFDECPLAPDTHIIMKIAAKTQSTMIGMGAKLYDEYLRLQIPFNTLYDLSKIHTVYSTGSPLKKECFAYINTYIAPGALIASISGGTDIIGCFVGGIKSLSITPGECQCLFLGMDIKSFNYMDEEIINSDEQGELVCVTPFPSMPSHFLNDTDGKKYRDAYFARLEPFWAHGDFVRVNHSTGGVEMLGRSDATLNRGGVRIGTAEIYSVVEKIPHIADCIVAGRLVEEGMDEEVLLFVKMVPGQELTHSIQAAIVSKLRNDMSPRHVPNKIYAVDDIPYTSSGKKVEVAVKQIVSGKAVQKASSIRNPESLDHFVQYRL
What is the function of this protein?
Activates acetoacetate to acetoacetyl-CoA (By similarity).  Negatively regulates let-60 Ras activity during vulval induction.
What are the official names of this protein?
Acetoacetyl-CoA synthetase, Suppressor of activated let-60 Ras protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DCDB_BIFLS
Sequence: MLLSDRDILAAQSAGHISLDPWTPEMVQPASIDVRLDRYFRLFNNHAYTYVDPAENQGALTEQFEVAPDEPWILHPGEFALGSTWEYVKLDPSIAARLEGKSSLGRLGILTHSTAGFIDPGFEGHITLELSNVSTLPVKLWPGMKIGQMCFFQLSSPAEHPYGSKGTGSHYQGQRGPTPSRSYENFYRAHIDD
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: Y142_RICCN
Sequence: MKLFPRSILITLVLSFALNLGIVTKIHAKDTLDSIVDILSGLTCETQGVGDLLRTEFSHTCIVAPFFTFAVMNLVSPVLYMNTFLKLKINDSDLFNDSNFGNFPGGQCTRENRIDPKNPELRFALCNNAKLIVSRAKSVAESALAIAKAVLTGSDPWDDIKTAWANKKKEYHVPYSGKPGDDGFAFDLGFPVIYWKVIQDKDRICVSTKGFTGDVPVGCKYMKEPFPKSMYNSFMDVADKDFIEDPNKTPTDPLALVSCSAAGDGCYQKAYNASKTAVVMTSPLIECMRQMIARLLISKDVCSFDNVSQVVNLVSRQDSVFFQFQVGMYKIVTAFLTLYVMFFGFKLLLAGEVPPKSEYINFILKMIFVTYFSIGINITPGNGSPYDRLDGMIQWAFPFLLDGINGLASWVMNAAPSGLCKFNNLSYDGTVSYIALWDALDCRVAHYLGLDILSTLLVENAYRSHDFLNFDFFSFSAPPYIYLLIPAIISGNMMLVSLALSYPLLVISVAAFMVNATIMCMISIVILGILAPLFVPMFLFAYTRNYFESWVKLMISFLLQPMVVVTFMITMFSVYDYGFYGKCQYKSKLIHNSIEDKIQGGITSKRDVLIFYINNDWDDTSQYPDKDAVESCQNSLGYMLNNPITTVFNFTKDSVSEIVGSKPGSTPTDKFLAKFQFLSGVVLGPGMFFMSPKVLFEKIKNILLALVMACFTLYLMYNFSSQLAEFAADMTEGVALNNVAIKPQAIFKAAMAVLATAGAATKGGDQIASRGGVGDLKAGQGGGASDLEVGKGGLPNDNIAASGGTSAPAVTTPTASSSVASSSPKTVSSEARSDVVTPPAPTEAVSPPPASIRTSISTLAPRVGKIIRDNNQESKKEIDNTPPSQEKVDNAAPQEKVDSTSKGTGVIDYSFNLKEHDNPTGVKQIRENAEIRDKRVKVEKAWNELVARGGGRVREQEGGEISERRANAEKAWDELVKSGVVTEKKDNSSNENS
What are the official names of this protein?
Uncharacterized protein RC0142.
What is the protein family that this protein belongs to?
Belongs to the TrbL/VirB6 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TMG1_PONAB
Sequence: MGRVFLTGEKANSVLKRYPRANGFFEEIRQGNIERECKEEFCTFEEAREAFENNEKTKEFWSTYTKAQQGESNRGSDWFQFYLTFPLIFGLFIILLVIFLIWRCFLRNKTRRQTVTEGHIPFPQHLNIITPPPPPDEVFDSSGLSPGFLGYVVGRSDSVSTRLSNCDPPPTYEEATGQVNLQRSETEPHLDPPPEYEDIVNSNSASAIPMVPVVTTIK
What are the official names of this protein?
Transmembrane gamma-carboxyglutamic acid protein 1, Proline-rich gamma-carboxyglutamic acid protein 1, Proline-rich Gla protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HBA2_VARAL
Sequence: VLTEDDKNHVKGLWAHVHDHIDEIAADALTRMFLAHPASKTYFAHFDLSPDNAQIKAHGKKVANALNQAVAHLDDIKGTLSKLSELHAQQLRVDPVNFGFLRHCLEVSIAAHLHDHLKASVIVSLDKFLEEVCKDLVSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-2, Alpha-2-globin, Hemoglobin alpha-2 chain, Hemoglobin alpha-II chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: HIS4_THENN
Sequence: MLVIPAIDLYRKKVVRMVKGKKENTIFYEKDPIELVEKLVEEGFSLIHVVDLSRAIEESDENLPVLEKLSSYADHIQIGGGIRILEYAKKLLGMGFRRQIVSSKVLEDPSFLKKLKEIGVNPVFSLDTREGKVAFKGWLDEKDIDPVFLVNRLKEFGLEEIVHTEIEKDGTLKEHDFSLTERIALETGVKVIAAGGISSERSLEEALEVHRRTNGLLKGVIVGRAFLEGTLTVEVMKRYACQENNSVS
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_LACLS
Sequence: MTKVNSQKYSKALLEVAQEKGQLEAILTEVSEMIQLFKENNLGAFLANEVYSFSAKSELIDTLLQTSSEVMSNFLNTIRSNGRLADLGEILEETKNAADDMFKIADVEVVSSIALSEAQIEKFKAMAKAKFDLNEVTVINTVNEKIIGGFIVNSRGKIIDASLKTQLAKIAAEIL
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL21_SHEB2
Sequence: MYAVFQSGGKQHRVAEGHTVRLEKLEVATGETIEFDQVLLIADGETVHVGAPLVAGGKVVAEVVSHGRGDKVTIVKFRRRKHHDKKMGHRQWFTEVKITAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: DIB1_ASHGO
Sequence: MGSVFLPHLHSGWHVDQAIVTEEERLVVIRFGSDSDRSCMLMDEILYSIAEKVVNFAAIYVCDTTEVPDFNEMYELQDPMTVMFFYKNKHMRCDFGTGNNNKMNFVVDNKQEMIDIIETVFRGARRNKGLVVSPYDYNYKRIQ
What is the function of this protein?
Essential role in pre-mRNA splicing.  Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis (By similarity).
What are the official names of this protein?
Spliceosomal protein DIB1.
What is the protein family that this protein belongs to?
Belongs to the DIM1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL18_DIACI
Sequence: MGVDICHKYDRRVRRTKPKSKDVYLELLVKLYRFLTRRTNSKFNKIILKRLFMSKINRPPMAISKIVRFMKKPTREGRVAVIVGTIVDDPRMWTIPKLTVCALRVTDKARSRILKAGGEIITFDQLALRAPTGKNTVLMQGKRTGREANKHFGPAPGVPHSHTKAHVRSKGRQFERARGRRTSKGYKK
What are the official names of this protein?
60S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL18 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAP1_DROME
Sequence: MREYKIVVLGSGGVGKSALTVQFVQCIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFVLVYSITAQSTFNDLQDLREQILRVKDTDDVPMVLVGNKCDLEEERVVGKELGKNLATQFNCAFMETSAKAKVNVNDIFYDLVRQINKKSPEKKQKKPKKSLCVLL
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.  Plays a role in photoreceptor cell determination.
What are the official names of this protein?
Ras-related protein Rap1, Rap1 GTPase, Ras-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: THIG_ECO7I
Sequence: MLRIADKTFDSHLFTGTGKFASSQLMMEAIRASGSQLVTLAMKRVNLRQHNDAILEPLIAAGVTLLPNTSGVKTAEEAIFAAHLAREALGTNWLKLEIHPDARWLLPDPIETLKAAETLVQQGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLETRAMLEIIIQQATVPVVVDAGIGVPSHAAQALEMGADAVLVNTAIAVADDPVNMAKAFRLAVDAGLLARQSGPGSRSHFAHATSPLTGFLEASA
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPPA_NATPD
Sequence: MELTVEPIDIGTERPVVLLNCADAETLGVHSLDRVEIDWDGTTEVGIVKVTDELVAAGRIGASHGFPEITDGTVVAVTPAGQPESVESIRRKLDGRELDSDELGAIVADIEADRLSDLELSAYVCASHANGLSLEETKQLTERMAEVGKQLSWEQPVVADKHSIGGVAGNRVTPVVVAIVAAAGLTIPKTSSRAVTSPAGTADTMEVFCPVEFSREEIRDIVTETGGCLVWGGAVDLSPVDDKVIRAQRPLSLDPPGQVIASVLSKKQSAGSSHIVVDIPYGAGAKVTSLSEARDLADDFRRVGDHLGLTIECALTRGSDPIGHGIGPVLEARDVLAVLEGEGPEPLRIKSLRLADIIFDMAREAGMPVDDRSAADILDSGAALSKFRDIVAVQGGDPDVSRDDLQPGDRTETVTADTDGLVVDVDNQAVSQLARRAGAPNDHGAGVVIHRRTGDKAVAGDVLYTIHAESSDRLEAAREYAAGDEIVRVGGRDEALVERR
What is the function of this protein?
Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P).  Exhibits phosphorylase activity toward CMP and UMP in addition to AMP.  Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
What are the official names of this protein?
AMP phosphorylase, AMPpase, Nucleoside monophosphate phosphorylase, NMP phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Protein: UL135_HCMVM
Sequence: MVWLWLGVGLLGGTGLASLVLAISLFTQRRGRKRSDETSSRGRLPGAASDKRGACACCYRIPKEDVVEPLDLELGLMRVATHPPTPQVPRCTSLYIGEDGLPIDKPEFPPARFEIPDVSTPGTPTSIGRSPSHCSSSSSLSSSASVDTVLHQPPPSWKPPPPPGRKKRPPTPPVRAPTTRLSSHRPPTPIPAPRKNLSTPPTKKTPPPTKPKPVGWTPPVTPRPFPKTPTPQKPPRNPRLPRTVGLENLSKVGLSCPCPRPRTPTEPTTLPIVSVSELAPPPRWSDIEELLEKAVQSVMKDAESMQMT
What is the function of this protein?
Remodels the host actin cytoskeleton in order to impair immune recognition of infected cells.  Mechanistically, interacts with members of the host WAVE2 complex and redirects the complex to the plasma membrane.  In turn, the efficiency of immune synapse formation is greatly reduced.
What are the official names of this protein?
Protein UL135.
What is the protein family that this protein belongs to?
Belongs to the HCMV UL135 family.
What are the subcellular locations of this protein?
Host cell membrane. Host Golgi apparatus.
Protein: CYB_ORTHE
Sequence: MMRKSHPLMKIVNHAFIDLPTPPNISGWWNFGSLLGLCLILQISTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRYMHANGASLFFICLYIHIGRGIYYGSYLYKETWNIGILLLFLTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGPDLVEWIWGGFSVDKATLTRFFALHFILPFIITALVLVHLLFLHETGSNNPLGIPSDCGKVPFHPYYTTKDFLGVIMILMLFLTTVLFLPDKLGDPDNYTPANPLNTPPHIXPEWYFLFAYAILRSIPNKLGGVLALVSSILVLALLPYLHTSKQRSLSFRPLSQTLFWMLVSDLILLTWIGGQPVEPPFIIIGQLASIMYFTIILLLMPVAGLIENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RUVB_TRIL1
Sequence: MERAITPEKRDDDLQFDATLRPRTLQDYIGQEKIRENLKLFIDAAKGRSEALDHVLLYGPPGLGKTTLANIIACEMGVNIKSTSGPVIERPGDLAAILTNLEPHDVLFIDEIHRLSHVVEEILYPAMEDFQLDIIIGQGPSARSIKLDLPRFTLVGATTRAGLLSSPLRDRFGVISRLEFYTHDELAFIVTRSARILGMAIDREGALELARRSRGTPRIANRLLRRVRDYAQVRADGAITLSVVQETLRLLEIDEMGFDQMDRMILLTIIDKFGGGPVGLDTIGAAIGEESDTIEDVYEPFLIQNGFLNRTPRGRVATPAAYQHFGRLTPERPQGSLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: AMN1_YEAST
Sequence: MKLERVSSNGSFKRGRDIQSLESPCTRPLKKMSPSPSFTSLKMEKPFKDIVRKYGGHLHQSSYNPGSSKVELVRPDLSLKTDQSFLQSSVQTTPNKKSCNEYLSTPEATPLKNTATENAWATSRVVSASSLSIVTPTEIKNILVDEFSELKLGQPLTAQHQRSHAVFEIPEIVENIIKMIVSLESANIPKERPCLRRNPQSYEHSLLMYKDEERAKKAWSAAQQLRDPPLVGHKEKKQGALFSCMMVNRLWLNVTRPFLFKSLHFKSVHNFKEFLRTSQETTQVMRPSHFILHKLHQVTQPDIERLSRMECQNLKWLEFYVCPRITPPLSWFDNLHKLEKLIIPGNKNIDDNFLLRLSQSIPNLKHLVLRACDNVSDSGVVCIALNCPKLKTFNIGRHRRGNLITSVSLVALGKYTQVETVGFAGCDVDDAGIWEFARLNGKNVERLSLNSCRLLTDYSLPILFALNSFPNLAVLEIRNLDKITDVRHFVKYNLWKKSLDAPILIEACERITKLIDQEENRVKRINSLVALKDMTAWVNADDEIENNVD
What is the function of this protein?
Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints.  Acts in the daughter cell to inhibit the mitotic exit pathway once MEN has executed its function.  Through its binding ability to TEM1, interferes with the TEM1-CDC5 association, required for CDC5 kinase activation and MEN activation.  Required for daughter cell separation and chromosome stability.  Involved in copper sensitivity.
What are the official names of this protein?
Antagonist of mitotic exit network protein 1, Chromosome stability protein 13, Increased copper-sensitivity protein 4.
What is the protein family that this protein belongs to?
Belongs to the AMN1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.