PharMolix/UniProtQA huggingface dataset:
Protein: PROF1_BOVIN
Sequence: MAGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGILVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNITVTMTAKTLVLLMGKEGVHGGMINKKCYEMASHLRRSQY
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG.  Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity).
What are the official names of this protein?
Profilin-1, Profilin I.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HEM2_MOUSE
Sequence: MHHQSVLHSGYFHPLLRSWQTAASTVSASNLIYPIFVTDVPDDVQPIASLPGVARYGVNQLEEMLRPLVEAGLRCVLIFGVPSRVPKDEQGSAADSEDSPTIEAVRLLRKTFPSLLVACDVCLCPYTSHGHCGLLSENGAFLAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKAALLKHGLGNRVSVMSYSAKFASCFYGPFRDAAQSSPAFGDRRCYQLPPGARGLALRAVARDIQEGADMLMVKPGLPYLDMVREVKDKHPELPLAVYQVSGEFAMLWHGAQAGAFDLRTAVLETMTAFRRAGADIIITYFAPQLLKWLKEE
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: RCF1_ASPTN
Sequence: MSDPLPSSFEDNPQFEEETGLQKFRRRLKEEPLIPLGCAATCYALYRAYRSMKAGDSVEMNRMFRARIYAQAFTLVAVVAGGMYFKTERQQRREFEKAVEERKSQEKRDAWLRELEIRDQEDRGWRERHAAMEAAANEAAKKAAVKPTAEQDAARSVIEAADQKSLGVLDAVMELMSRQK
What is the function of this protein?
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
What are the official names of this protein?
Respiratory supercomplex factor 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RCF1 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: EFG2_GEOSL
Sequence: MARQVSLEKTRNIGIMAHIDAGKTTTTERILYYTGVTHKIGEVHEGAATMDWMEQEQERGITITSAATTCFWGDHRVNIIDTPGHVDFTIEVERSLRVLDGAVAVFCSVGGVEPQSETVWRQADKYRVPRIAFINKMDRVGADFFRGVGMIRDRLKANPVPIQLPIGAEDTYRGVVDLVEMKAIIWDEESLGAKYHEAEIPADLAEMAQEYREKLIEEIATFDDALMEKYLGGEELTTDEIKAAVRKATIDIQICPVICGSAFKNKGVQNLLDSVVAYLPSPLDIPAITGIDAKSGEEITRKASDDEPFSALAFKIMTDPFVGQLCFFRVYSGVLNSGSYVYNSTKEKKERIGRLLKMHANKREEIKEVYAGDIAAAVGLKYTTTGDTLCPEDSPVVLESIEFPEPVIAIAIEPKTKADQEKLGISLQKLASEDPSFRVRTDEETGQTIISGMGELHLEIIVDRLMREFKVEANVGKPQVAYRETVTKKVKVEGKFVRQSGGRGQYGHVWIELEPQEAGKGYEFVDAIKGGVVPREYIPAVDKGIQEAMETGVLAGYPTVDFKVALVDGSYHEVDSSEMAFKIAGSMAFKEAAAKAGPVLLEPIMSVEVVVPEEYMGDVIGDLNSRRGRIMGMEGRAGAQVVSAMVPLAQMFGYATDLRSATQGRATYTMTFDHYEQVPKSVSEEIVAKVKG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 2, EF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COPD_RAT
Sequence: MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQGKKAPGFGGFGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGPSKALKLGAKGKEVDNFVDKLKSEGETIMSSNMGKRTSEAAKVHAPPINMESVHMKIEEKITLTCGRDGGLQNMELHGMIMLRISDDKFGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSDVGVLKWRLQTTEESFIPLTINCWPSESGNGCDVNIEYELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIPGQPNDFFPVQVSFISKKNYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.  In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
What are the official names of this protein?
Coatomer subunit delta, Archain, Delta-coat protein, Delta-COP.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: RS16_ACIB3
Sequence: MVVIRLARGGAKKRPFYQIVVTDSRNARDGRFIERIGFFNPTAQGQAEKLRLDADRFAHWVSQGAQPSERVASLAAQAKKATA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: CB2_CHLRE
Sequence: MAFALASRKALQVTCKATGKKTAAKAAAPKSSGVEFYGPNRAKWLGPYSENATPAYLTGEFPGDYGWDTAGLSADPETFKRYRELELIHARWAMLGALGCQTPELLAKSGTKFGEAVWFKAGAQIFSEGGLDYLGNPSLVHAQNIVATSAVQVILMGLIEGYRVNGGPAGEGLDPLYPGESFDPLGLADDPDTFAELKVKEIKNGRLASFSMFGFFVQAIVTGKGPVQNLDDHLANPTVNNAFAFATKFTPSA
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
What are the official names of this protein?
Chlorophyll a-b binding protein of LHCII type I, chloroplastic, CAB, LHCP.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: HSP1_TRAFR
Sequence: MARYRCCRSQSRSRCCRPRRRCRRRRRRSCRARRRATRCCRRRYRLRCRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PUR2_THEGJ
Sequence: MRVLLVGGGGREHAIGEALVRGGAELYVVSKHKNPGLARLARGYGLAKETDIKKVLEYAEKFGVELAFIGPEAPLEKGIVDALEENGIPAVGPSREAAKLETDKAFARTFMERNEIPGRKVFRVFTDVSKMRSWVDDFGRPVVVKPIGLTGGKGVKVVGYQLRDNEEAKSYAEELIRRDGRVLIEERTNGVEFTFQVFTDGKRVLPMPLAQDYPHAYENDEGPITGGMGSYSCSNGLLPFVTREDYEKALETLKATVEAMRKEGTPYKGILYGQFMLSKGGPVLIEYNARFGDPEAINVLPLLETSLLEVAEGIVDGNLQGAEFEKKATVVKYLAPKGYPTNPVRGVKVEVNEKAVEEVGARLYYASIDENFTLLGSRAIAVVGIADSLEEAERIAKSVIPHVKGELFYRRDVGTRKSVEKRIELMKEFGKEFEPNPC
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: KDPB_LISMH
Sequence: MMEKGIWKDALIQSTKKLSPKLQLKNPVMLLVYVGAILATSLYFLGFFGISDEKSGYTLAIALILWFTVLFANFAEAIAEGRGRAQADSLKMARKDVLARKLKNIDDKTDVIEIASNDLKKGDIVYVLANEQIPMDGEVIEGAASVDESAITGESAPVIRESGGDRSAVTGGTTLVSDWLVVRVTAVSGESFLDKMIAMVEGASRKKTPNEIALQILLVTLSIIFLTVSATLLPFTEFASKQAGAGSAISITNVIALLVCLAPTTIGALLSSIGIAGMSRLNQANVLAMSGRAIEAAGDVDVLLLDKTGTITLGNRKASEFLPVDGVTEQELADAAQLSSIADETAEGRSIVVLAKERFDIRGRDFAEMHAEFVPFTATTRMSGIDYQENTIRKGAADAVRAYVTANGGTYPKECDAIVSKVAGAGGTPLVVVRNNKVLGVIYLKDIVKNGVKERFLDLRKMGIKTIMITGDNPMTAAAIAAEAGVDDFLAEATPEAKLELIREYQREGHLVAMTGDGTNDAPALAQADVAVAMNTGTQAAKEAGNMVDLDSSPTKLIDIVRIGKQLLMTRGALTTFSVANDLAKYFAIIPVLFYGIFPQLEALNLMGLTSPTSAILSAIIYNAVIIIILIPLSLKGVKYREMPAGKLLSRNMLIYGLGGLIAPFIAIKLIDMLLTVLGIV
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COBQ_ALCBS
Sequence: MATLMVQGCTSDAGKSTVVAALCRWFARRGYSVAPFKPQNMALNSAVTVDGGEIGRSTALQALACGVAPHSDMNPVLLKPQTDMGAQVIIRGKVLGNMQALDYHAYKNTASEAVLAAWQDLSSRFDVIIAEGAGSPAEINLRDNDIANMGFAERVDCPVIVVADIDRGGVFAHLTGTLDLLSESEQKRTLGFVINRFRGDLSLLQGGLDWLEERTGKPVFGVLPYLHGLTLDAEDAVDEQGAHDVGAFNVVVPLLPRMSNHNDFDPLRLHPQVNLQFVKMGEAWPSADLIILPGSKATRADLAFLRQQGWDKQIEKHLRYGGKVLGICGGFQMLGERIDDPEGLESDAGSSAGLGWLSMTTRLISGKQLRNVEGRFVAADTLIRGYEIHNGLTQGEALKHPMLVLEGRDDGAMSEDGRVMGCYLHGLFDVPDSCNTILEWAGLKSQRSVDYAVHREQQLDRLADMLEEHLDMTRLKQCMGS
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: RL24_THENN
Sequence: MRMRIKKGDLVEVISGKDKGKRGKVLRVLPKEDKVIVEGVNMVKRHQRPIPQLREGGIIEREAPIYACKVMVVCPACDKRTRVGYRFTEDGKKVRYCKKCGEIIDKD
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: TEC1_CANAL
Sequence: MMSQATPSATPVRNADGQKKGKKLPLIVDVAIGNNGKQLYQVHESSKMVRKEMPRSTNFALNDDISDEGFFISQINEQRTPIRKTLGTLSPSSLNQKRIRHDVYDQGDDNSNDDNCQNDVYEQQQQQPQQQQQQQQQLHQPNMYENGNVGVISNDPVSSVGHYDNNPVSHVPTGAYSRVQDTDIWSDDVEEAFEEVLRLIPKSGLNKIKIAGRSCGRNELISDYIFAKTGKFRTRKQVSSHIQVIKNLGQKLDIIQLINDGPIFNSHEEQLESTKKFEDVFSKINLNKSLGFSDSMKRKSDSMPMHLPATKRIRRKHSGNPLNKIKFSNFFMSVNDQYGMNPIVLTIQQNGNDVKSLKLKDNANISSRFPGLSDFKSCPHIPIIHNMVKILLPQLPESYSIDDGFSSSYALKYEEPENASPTHTSIISSSRTYSLFTCVYSYGKEIVKFDEDGIQLNQDREFIPGFWKFFFSTFGDQSEGGLSAAFKGVTIKQILYESSPDSVKKEQDASKVNKSKVKLVLLWEFAKVSECKDALTTTTKLVLPPRASASSSKTTEEVFEYSEPALNSIGGTPTDTTSPNMDLNNQNLSAAATSIPGIRDTIHSASMPDINELPSSAKPQVRLQKTFQSMQHLQPHQMWQQQQQQQPSQGAYTSSVASQSLNTSLSSPYAQYGMPLPQQTIGTFVPPTSQTFGVSYTHNSQHPSANMDLMMLSSMNTGYGNITNNQDYQFGNIGYTEGFTSEF
What is the function of this protein?
Transcription factor which regulates genes involved in hyphal development, cell adhesion, biofilm development, and virulence.  Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C. albicans induced by carbon dioxide.  Regulates gene expression during intestinal colonization.  Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24.  Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tube which is important for hyphae formation.  Regulates also the pheromone response of the white cell phenotype.
What are the official names of this protein?
Transcription activator TEC1.
What is the protein family that this protein belongs to?
Belongs to the TEC1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FFSC_ASPFV
Sequence: MSPARTLESSPLPTTQTAIIQGEGGILSIHHNAPLPTLRPDRILVKVAYVAINPCDWKMADRFPTPGCVDGCDFSGTVVALGSDWAKTGRFKIGDRVCGGVHGSNPIDQSTGCFADYVSADAQFTFHVPEYMGMEDAAAVGGTGIGTLGLALKRSLGLPGSPRDPVPESESVQVLVYAASTSVGTLATQLLRMSGHKPIGVCSAKNFDMVKSYGAVKLFDYHSPTCAQDIRAYTKNTLAHILDPITEPKTTELCYAAMGRAGGKYCALEAFAEEFCTRRVVKPELVMGMAILGGRIALDYGYESEADPEKRVFGVSWYEEMQELLDSGRLRNHPVRSFPGGFEGIMKGLHLLKTKQVSGEKLIVQLG
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of the cytotoxic leucine-containing cytochalasans, including aspochalasin C, aspochalasin E, TMC-169, flavichalasine F, aspergillin PZ, aspochalasin M and flavichalasine G (PubMed:32913332).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS ffsA that utilizes 8 units of malonyl-CoA to iteratively assemble the octaketide chain before addition of L-leucine by the C-terminal NRPS modules (PubMed:32913332).  Because ffsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase fssC (Probable).  The methyltransferase (MT) domain of ffsA catalyzes the alpha-methylation at C10 and C14 using S-adenosyl-L-methionine as the methyl-donating cosubstrate (Probable).  Reduction by the hydrolyase ffsE, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ffsF then yield the required isoindolone-fused macrocycle (By similarity).  A number of oxidative steps catalyzed by the tailoring cytochrome P450 monooxygenase ffsD, the FAD-linked oxidoreductase ffsJ and the short-chain dehydrogenase/reductase ffsI, are further required to afford the final products (Probable).
What are the official names of this protein?
Trans-enoyl reductase ffsC, Cytochalasans biosynthesis cluster protein ffsC.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: URE1_MYCUA
Sequence: MARLSRERYAQLYGPTTGDRIRLADTDLLVEITEDRCGGPGLAGDEAVFGGGKVLRESMGQGRVTRAEGAPDTVITGAVIIDYWGIIKANIGIRDGRIVAIGKAGNPNIMSGIHPDLVVGPSTEIIGGNGRIVTAGAIDCHVHLICPQVIAEALSSGITTIIGGGTGPAEGSKSTTVTPGGWHLARMLEALDSWPVNIALLGKGNTVNPDALWEQLRGGASGFKLHEDWGKSPAAIDACLTVADAAGVQVALHSDTLNEMGFVEDTLAAIAGRSIHTYHTEGAGGGHAPDIITVAAHPNVLPSSTNPTRPHTVNALDEHLDMLMVCHHLNPRIPDDLAFAESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRVGEVVMRTWQTAHVMKQRRGALEGDPSGRYSADNNRARRYVAKYTICPAVAHGLDHEVGSVEVGKLADLVLWEPAFFGVRPHAVVKGGAIAWAAMGDANASIPTPQPVLPRPMFGASPAVAAATSVHFVAAQSIEAGLADQIAVDRRLVPVADVRAVGKADMPLNDAQPRIEVDPDTFTVRIDGEVWEQQPATELPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_BURO0
Sequence: MLQPKRRKYRKEQKGRNTGKATRGNAVSFGEFGLKAIGRGRLTARQIEAARRAMTRHIKRGGRIWIRIFPDKPISQKPAEVRMGNGKGNPEYYVAEIQPGKMLYEMDGVTEELAREAFRLAAAKLPLKTAFIVRQLGA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: MDTL_SHIFL
Sequence: MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPASPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTFSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYC_POLSJ
Sequence: MSLRIYNTLSRDVEVFSPLLPGHVRMYVCGMTVYDLCHLGHARAMVAFDVVQRWLKVSGLKVTYVRNVTDIDDKIIKRAVENGETIRSLTDRMVVALHQDADALGIERPTHEPRATDFVPQMLSLIGTLEKKGLAYQTQSGSGQGDVNYAVRKFDGYGKLSGKSLDELRAGERVEVLDGKDDPLDFVLWKSAKPSEPDDAKWDSPYGPGRPGWHIECSAMACELLGESFDIHGGGADLQFPHHENEIAQSEGAFGKPLAGTWMHNGFVRVDNEKMSKSLGNFFTIREILAKYDAETVRFFIIRAHYRSPLNYSDAHLDDARNSLKRLYTALDLVSPAVVAIDWTNPFAARFKAAMDEDFGTPEAVAVLFDLAGEVNKTRSAELAGLLKSLGGCLGLLQSAPGSYLQAGAGLDDASIQRLIAQRADAKKTKNFAEADRIRNDLLGQGIVLKDSPAGTTWEVQS
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I83A5
Sequence: MNPNQKIITIGSVSLTIATVCFLMQIAILATNVTLHFRQNERSIPAYNQTTPCKPIIIERNIKYRNWSKPQCQITGFAPFSKDNSIRLSAGGGIWVTREPYVSCDPSKCYQFALGQGTTLDNNHSNGTIHDRTPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCVTGDDRNATASFIYNGMLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGKADIRILFIREGKIVHISPLSGSAQHIEECSCYPRYPNVRCVCRDNWKGSNRPVIDINMADYSIDSSYVCSGLVGDTPRNDDSSSSSNCRDPNNERGNPGVKGWAFDIGDDVWMGRTISKDSRSGYETFRVIGGWATANSKSQTNRQVIVDNNNWSGYSGIFSVESKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPL
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: ALBA_THEKO
Sequence: MAEEHVVYIGKKPVMNYVLAVITQFNEGAKEVSIRARGRAISRAVDVAEIVRNRFLPEVRVKEIKIGTEELPTADGRTANTSTIEIILEKP
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).  Incubation with DNA in vitro gives fibrous structures 10. 3 +/- 1. 1 nm in thickness (naked DNA is 1. 83 +/- 0. 37 nm).  This protein does not significantly compact DNA (PubMed:21148291).
What are the official names of this protein?
DNA/RNA-binding protein Alba.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: XYN1_MAGGR
Sequence: MVSFTSIVTAVVALAGSALAIPAPDGNMTGFPFEQLMRRQSTPSSTGRHNGYYYSWWTDGASPVQYQNGNGGSYSVQWQSGGNFVGGKGWMPGGSKSITYSGTFNPVNNGNAYLCIYGWTQNPLVEYYILENYGEYNPGNSAQSRGTLQAAGGTYTLHESTRVNQPSIEGTRTFQQYWAIRQQKRNSGTVNTGEFFQAWERAGMRMGNHNYMIVATEGYRSAGNSNINVQTPA
What is the function of this protein?
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.  Accounts for approximately 70 percent of the endoxylanase activity in the culture filtrate.
What are the official names of this protein?
Endo-1,4-beta-xylanase 1, Xylanase 1, 1,4-beta-D-xylan xylanohydrolase 1, Xylanase 22.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 11 (cellulase G) family.
What are the subcellular locations of this protein?
Secreted.
Protein: LRP11_HUMAN
Sequence: MASVAQESAGSQRRLPPRHGALRGLLLLCLWLPSGRAALPPAAPLSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPDAIIRTKDSLAAGASFLRAPAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLGCYLFNCTARGRNVCKFALHSGYSSYSLSRAPDGAALATARASPRQEKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDDHAIVQYEWALLQGDPSVDMKVPQSGTLKLSHLQEGTYTFQLTVTDTAGQRSSDNVSVTVLRAAYSTGGCLHTCSRYHFFCDDGCCIDITLACDGVQQCPDGSDEDFCQNLGLDRKMVTHTAASPALPRTTGPSEDAGGDSLVEKSQKATAPNKPPALSNTEKRNHSAFWGPESQIIPVMPDSSSSGKNRKEESYIFESKGDGGGGEHPAPETGAVLPLALGLAITALLLLMVACRLRLVKQKLKKARPITSEESDYLINGMYL
What are the official names of this protein?
Low-density lipoprotein receptor-related protein 11, LRP-11.
What is the protein family that this protein belongs to?
Belongs to the LDLR family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SYA_SHESH
Sequence: MYQTTAALRSAFLEYFRTNGHQVVDSSSLVPVNDPTLLFTNAGMNQFKDVFLGEDKRSYTRATSSQRCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKRDAISFAWNFLTQELKLPKERLCVTIYETDDEAYDIWTKEIGVPAENLIRIGDNKGAPYASDNFWQMGDTGPCGPCSEIFYDHGDHIWGGRPGTPEEDGDRFIEIWNIVFMQYNRQSDGEMLPLPKPSVDTGMGIERIAAIMQGVHSNYEIDIFQALIKKTAEILSVTDLENKSLRVISDHIRSCAFLIADGVMPSNEGRGYVLRRIIRRAVRHGNKLGASDSFFYKLVPTLIEVMGDAAKGLVATQAIVEKSLKAEEEQFARTLERGLGILDGALNALKGDVLDGETAFKLYDTYGFPVDLTADVCREREITVDEAGFEVAMAEQRSRAQAAGQFETDYNDSLKIDELTHFSGYTELTAPGKITAIYMAGESVNSLSAGDEAVIVLDSTPFYGESGGQCGDRGVLSAKGIEFDVKDTQKYGQAVGHQGALTSGTLSVGDSLEANVDKKLRHRTELNHSVTHLLHAALRQLLGTHVTQKGSLVDSERLRFDFSHFEGVKPEELKAVEDLVNTQIRRNHKLSAEVMDMDQAKEKGAMALFGEKYTDEVRVVTMGDFSIELCGGTHVGRTGDIGLFKITSEGGIAAGVRRIEAVTGAAAMAYVAGQKAELDQAAALLKADSASVVSKLKAQLDRTKLLEKELSQLKDKLAAATSADLAGEAQQVNGVNVLVKKLDGVEAGALRGLQDELKQKLGSGIVVLGIAGDAKVNLIVGVTKDLTSKVKAGELVASIASQVGGKGGGRPDMAQAGGSQPENLDSALEQVIPWLTERLA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.