PharMolix/UniProtQA huggingface dataset:
Protein: BDS2_ANTEL
Sequence: GTACSCGNSKGIYWFYRPSCPTDRGYTGSCRYFLGTCCTPAD
What is the function of this protein?
This toxin potently blocks acid-sensing ion channel ASIC3 homotrimers and heterotrimers containing ASIC3 (composed with isoforms of ASIC1 and ASIC2) (PubMed:15044953).  It also weakly inhibits potassium channels, and sodium channels (PubMed:15044953, PubMed:21943094, PubMed:22972919, PubMed:25337890).  On homomeric ASIC3, this protein shows IC(50)=57-87 nM on rat, 37. 3 nM on mouse and 175 nM on human channels (PubMed:15044953, PubMed:18923424, PubMed:19306891, PubMed:20813121, PubMed:21943094, PubMed:22851922, PubMed:22851929).  The blockade is rapid and reversible (PubMed:15044953).  On heterotrimeric forms, the toxin is less potent (IC(50)=117 nM on rat ASIC2b-ASIC3 channel, 900 nM on rat ASIC1b-ASIC3, and 2 uM on rat ASIC1a-ASIC3) (PubMed:15044953).  It weakly inhibits Kv3. 4/KCNC4 potassium channels (3 uM of the toxin inhibits 38% of Kv3. 4 current) (PubMed:15044953).  It reversibly and voltage-dependently inhibits hKv11. 1/KCNH2/ERG1 potassium channels (IC(50)=1. 21 uM), inhibiting both peak and tail currents without action on channel inactivation (PubMed:25337890).  It weakly inhibits rNav1. 2/SCN2A (EC(50)=114 nM), rNav1. 6/SCN8A current (17% at 1 uM of the toxin) and Nav1. 8/SCN10A (IC(50)=6. 6 uM on human channels expressed in oocytes, EC(50)=55 nM on rat channels expressed in oocytes, and 2. 6 uM on rat channels in DRG neurons) (PubMed:21943094, PubMed:22972919).  It may act on sodium channels by binding at site 1 or close by, when the pore is in an open configuration (PubMed:22972919).  In vivo, central injection does not induce neurotoxin symptoms in mice even after 24 hours (PubMed:15044953).  However, it abolishes acid-induced pain in rats (PubMed:18923424).
What are the official names of this protein?
Pi-actitoxin-Ael2b, Pi-AITX-Ael2b, Toxin APETx2.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RPIA_POLNS
Sequence: MNQDQLKQMVGEAARDEVLKLPAGQVLGVGTGSTANYFIDALALHKGHFAGTVSSSNATTERLLKHGFKVLDPNDVQGLPAYVDGADEIDPAGHMIKGGGGVLTGEKIIASMAKQFICICDSSKQVPVLGNFALPVEIIPLSQGVVSRELEKFGGRVTLRLAKHTRADLNQTPSEPFVTDNGGWILDVAGLRIASPAQMEAQINQIAGVITVGLFAKEKANILLVSNAAGVERIQF
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: RIMM_FRACC
Sequence: MAEEIVVGRIGRPHGIRGEVTIEIRTDVPHRRFVVGAVLGREGGGTALTVSGAHWHSGRLLLHFRGVDDRGAAEALRGVLLTIDADQAGSPLDDADGDGEAVEMWWDRDLVGLRAVTTAGMLLGHVTDIIHSPAGDLLAIGGPDGGEHLVPFVRDIVPTVDPPAGRIVVDPPPGLLDLD
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCSA_ECOLX
Sequence: MSTIIMDLCSYTRLGLTGYLLSRGVKKREINDIETVDDLAIACDSQRPSVVFINEDCFIHDASNSQHIKHIINQHPNTLFIVFMAIANVHFDEYLLVRKNLLISSKSIKPESLDDILGDILKKETTITSFLNMPTLSLSRTESSMLRMWMAGQGTIQISDQMNIKAKTVSSHKGNIKRKIKTHNKQVIYHVVRLTDNVTNGIFVNMR
What is the function of this protein?
Component of the Rcs signaling system, which controls transcription of numerous genes.  Binds, with RcsB, to the RcsAB box to regulate expression of genes (By similarity).  Involved in regulation of K30 capsular polysaccharide synthesis.
What are the official names of this protein?
Transcriptional regulatory protein RcsA.
What is the protein family that this protein belongs to?
Belongs to the RcsA family.
Protein: RET3_RABIT
Sequence: SHLFQPSLVLDMAKVLLDNYXFP
What is the function of this protein?
IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
What are the official names of this protein?
Retinol-binding protein 3, Interphotoreceptor retinoid-binding protein, IRBP, Interstitial retinol-binding protein.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
Protein: NUOA_RHOCA
Sequence: MQDALTHGMLREYLPILVLLAMAIGLGLILIAAAAIIAYRNPDPEKVSAYECGFNAFDDARMKFDVRFYLVSILFIIFDLEVAFLFPWAVAFGDMSMTAFWSMMVFLSVLTVGFAYEWKKGALEWA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUR5_PROM3
Sequence: MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLIRLPAGLNKPLLVAGTDGVGTKLELAQQHQAHYGVGLDLVGMCVNDVITSGAEPLFFLDYIATGTLSPEAMAQVVEGIAEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEEDEMIDGRKIKPGDQIIGVASSGVHSNGFSLVRKVLALTEANKNTRFGCDNKPLIETLLTPTTLYGQLVRNLLEAKVPLHGMAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGFCLVVAEEAVRDVLQVCKEQALQAWPIGQVETASPSTGERLRGLPS
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_PAEAT
Sequence: MGIRKYKPTTPGRRGSSVADFAEITRSTPEKSLLRPLHKTGGRNNSGKITTRHKGGGHKRQYRLIDFRRHDKDGINARVAEIEYDPNRTARIALLHYVDGTKRYIIAPNKLSQGDFVEAGPDADIKPGNNLPLRNIPVGTVIHAVELRPGGGAKMARSAGASVQLVAKEGRFAQLRLPSGEIRNVDVRCRATVGEVGNAEQSNINWGKAGRMRWKGVRPTVRGVAMNPVDHPHGGGEGKTSGGRHPVNPNGKPEGRTRRPNKESDKLIVRRRRTGKNKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: MSL1_YEAST
Sequence: MVEPARKKQRIDRDTHHTVAEPVTEAKNTLYVSQLNEKINMQRLRVNLFLLFATFGEVLKVSMNFKKQRGQAFITMRTIDQASLAQISLNGERFFGKPLKVEFSKSETKTL
What is the function of this protein?
Involved in pre-mRNA splicing.  This protein is associated with snRNP U2.  It binds stem loop IV of U2 snRNA.
What are the official names of this protein?
U2 small nuclear ribonucleoprotein B'', U2 snRNP B''.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUOH_RUEST
Sequence: MAEFFNTPGGIAVIILAQTLAVVAFVMISLLFLVYGDRKIWAAVQMRRGPNVVGVYGLLQTVADALKYVVKEVVIPAGSDRTVFILAPLTSFVLAMIAWAVIPFNDTWVLSDINVAILYVFAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEVSIGLIIIGVILSTGSMNFGDIVRAQDGDAGLFNWYWLPHFPMVFLFFISCLAETNRPPFDLPEAESELVAGYQVEYSSTPFLLFMAGEYIAIFLMCALTSLLFFGGWLSPVPFLPDSPLWMVAKMAFFFFLFAMVKAITPRYRYDQLMRLGWKVFLPFSLIWVVFVAFAARFEWFWGAFARWSTGG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UPPS_THEKO
Sequence: MLYRLVSHIPHILFKPVYDAYESYLLEKVKSGNIPKHVAIIMDGNRRWARKLEKPPWYGHLFGSKKLEEILEWCRELNIRTLTVYAFSTENFKRSKEEVEALMNLFEEKFKELVQDERVHRYGIRVNVLGRKDMLPENVRKAAEEAERATRKYSNYNLNIALAYGGRSEIADAVREIVRDVLEGKIKPEDIDEEAIKRYLYYPNMPDPDIVIRTGGEVRISNFLLYQIAYSELFFVDVYFPEFRKIDFLRIIREFQKRQRRFGR
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP).  It is probably the precursor of glycosyl carrier lipids.
What are the official names of this protein?
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific), Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: RL27_XANP2
Sequence: MAHKKAGGSSRNGRDSDGRRLGVKRFGGQDVIPGNIIVRQRGTKWHPGTNVGMGKDHTLFALVEGKVTFQTKANDRTYVSVLPLAAEAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SYFA_FRATW
Sequence: MQIVEQMKDKALAELNLVKDKKTLDDIRVKYLGKKGELTEMMKLIATLPNDEKPKLGQAVNIAKQALQEAINLKLANFEEQELNEKLAQEKIDITLSGVGQNQGSLHPVTKTLNRIEAFFKQNGFAIEFGPEIESDYYNFETLNIPSHHPARAMHDTFYIDETHVLRTHTSGVQIRTMEKQQPPIRIIAPGRVYRCDSDITHTPMFHQVEGLLVDKDVSFADLKGLLHAFLNSFFEKDLKVRFRPSYFPFTEPSAEADIECVMCDGKGCRVCKHTGWLEVLGCGMVHPKVLKAGNIDSEKYQGFAFGMGVERLSMLRYGIDDLRMFFENDLRFLKQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPFD_MYCLB
Sequence: MSTFIGQLVGFAAIVYLVWWYVVPPVCRLMRARRDAVRQQLTEAAEAADRLVEASQAHTKATEDAKVEAQRVVKEAVEDAKRIVEQLQAQADVEAERIKLQGARQVELLRAQLTRQLRLKFGHESVRQAAELVRNHVADAVQQSATVDRFLDDLDAMTPKGADVEYPLLAKMRSASRRALVDLADRFGAIAKSLDNQALYTLAGELVSVAKMLDREIVVTRYLTVPVEDEAPRVKLIDRLVSAHVGDPTMEILRAAVSERWSANTDLVDALEHISRQALLEVAEREDQIDEVEDQVFRFSRILDVAPRLAILLDDYAVPADSRVRLLCNVLQSASSVVNPIAVALLSQTVELLRGQPAKEAILFLAEVAVARRGEVVAQVSAAAEISDAQRTRLTEVLSRIYGHPVTVQMQIDAALLGGLSIVVGDEVIDGTLSSCLVAAEAALPD
What is the function of this protein?
This fusion protein includes a component of the F(0) channel (subunit b) and of the F(1) subunit (subunit delta).  Two copies of subunit b and one of delta together form the peripheral 'stator' stalk which links F(1) to F(0) (By similarity).
What are the official names of this protein?
ATP synthase subunit b-delta.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ARNT1_PSEPF
Sequence: MTSENNPLRHTALFPSTTAVERWAIPGLILAFVMFYLLPLMSHGLWIPDETRYGQISQEMLLSGNWVAPHFMGIRYFEKPIAGYWMIAIGQAIFGDNLFGVRIASALSTGVSVWLTYLLARRLWNNPRINAASALLYMSFGLIAGQAGYANLDPQFTLWVNLSMVAVWFAIDNRTPRARLGGWALLGVACGMGLMTKGFLALLLPVLIALPYMLWQRRFGELVRYGLVAVVVCALVSLPWVLAVHYREPDFWRFFFWHEHIRRFAAGDDAQHARPWWFYLPLLFASTLPWALLLPSTLLRMWREKREAKMAYLALWFLLPLAFFSLSSGKLPTYIMPCLLPVALLMGQTVVKWLDQRSGRFLRLNGVFNTVLASVALVALLYLQATKEIYENTEMFSLSLAYIVVVGWIIANALQVLRPLTLWAMPALGIGLLVALLPAAMPAQIVNSKMPDQFIAEHQRELSETASLLSNDLGAASALAWRLKRPQVDLFNTIGELKYGLEDPAMEARKVTMDGVGQWMTEARKKGAVGVVLRVNSTQEEQEVELLPVDGKHYRRGNLHIFIFAQKQP
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1, 4-amino-4-deoxy-L-arabinose lipid A transferase 1, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: URE2_KLEP7
Sequence: MIPGEYHVKPGQIALNTGRATCRVVVENHGDRPIQVGSHYHFAEVNPALKFDRQQAAGYRLNIPAGTAVRFEPGQKREVELVAFAGHRAVFGFRGEVMGPLEVNDE
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNX15_BOVIN
Sequence: MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKRDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRGQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPSEVSGDLHILPPPLIPTPPPDEPRVQPHETWLPQPLPAERRGLEELEVPADPPPSSPAQEALDLLFNCGSTEEASSSPARGPLTEAELALFDPFSKEEGAGPSPTHIGELAALEAGSGRPDQEPWEPGGQAEEDDEEGEPAPAYLSQATELITQALRDEKAGAYPAALQGYRDGVHILLQGVPGDPSPARREGVKKKAAEYLKRAEEILHLHLS
What is the function of this protein?
May be involved in several stages of intracellular trafficking.  Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity).
What are the official names of this protein?
Sorting nexin-15.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
Protein: ELP3_CAEBR
Sequence: MDDKGSQRALLAQTVNEIVKLLIEAHNQKKDVNLNRLKCIVAQKNGLSFQPKLVDIIAGVPADYKDTLLPKLKAKPVRTASGIAVVAVMSKPHRCPHINFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYNPYLQTRGRLNQLMQLGHSVDKVEFIVMGGTFMSLPEDYRDFFIRNLHDALSGHTSASVEEAVAYSERSKMKCIGITIETRPDYCLPRHLNDMLLYGCTRLEIGVQSTYEDVARDTNRGHTVKSVCETFHMAKDTGYKVVIHMMPDLPNVGLERDKEQFLELFESPAFRPDGLKLYPTLVIRGTGLYELWKTGRYQSYPPSVLVDLIATILSLVPPWTRVYRVQRDIPMPLVSSGVEHGNLREHAMAKMKELGLKCRDVRTREVGIQEIHNKVRPEDVELIRRDYTANGGWETFISYEDPKQDILIGLLRLRKISDKAHRAELKGNVSVVRELHVYGSVVSVADRDPKKFQHQGYGSLLMEEAERIAREEHESDKIAVISGVGTRDYYRKLGYELDGPYMSKTLDASSAA
What is the function of this protein?
Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity).  In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
What are the official names of this protein?
Elongator complex protein 3, tRNA uridine(34) acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ELP3 family.
Protein: SYFA_BUCAP
Sequence: MLILQKLFDSVKIEIKNSHTIDKLDHIRIKYLGKKGIFSNLIKDLKNFSLEERKKYFIIFNEIKKKTINQINKKKIELNKIILDKQIEKEKIDVSLPGRRIKNGVIHPINHTITYIKNFFSKLGFESISGFEIEDEYHNFDALNIPKDHPARNIHDTFWFDENRLLRTQTSSMQIRIMKKEKPPIRLIFPGKVYRNDYDSTHTPMFHQVEGLIVEKNINFSNLKWIIYNFLRNFFHKDIAIRFRPSYFPFTTPSAEVDVVTNNGKLLEVLGCGMVHPSVLKNVNIDSNFYSACAFGIGIERITMLRYGISDLRSFFENDIRFIKQFKHI
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_GEOKA
Sequence: MYKDIATPGRTKEILERYGFSFKKSLGQNFLIDANILRKIVDVADISPDTGAIEIGPGIGALTEQLARRAKKVVAFEIDGRLLPILADTLSPYDNVRIFHQDVLKADLHAVIAEELADVSDRMVVANLPYYVTTPIIMKLLTERLPIRGMVVMLQKEVADRLAAKPGTKDYGSLTIAVQYYTEAEVIMTVPRTVFMPQPNVDSAVIRLVKRQHPPVVVDDEGVFFQVVRASFAQRRKTLFNNLTNNLPGGKENKEQIERVLVALGIDPRRRGETLDIAEFASLSNALAPLFGK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_ERWT9
Sequence: MQILLANPRGFCAGVDRAISIVERALEMYGAPIYVRHEVVHNRYVVNSLRERGAIFIEEIDEVPDGSILIFSAHGVSQAVRAEAKARALTMLFDATCPLVTKVHMEVARASRKGTEAILIGHAGHPEVEGTMGQYNNPQGGMYLVEQPGDVQNLQVKDEDNLCFMTQTTLSVDDTSDVIDALRARFPKIVGPRKDDICYATTNRQEAVRTLARDADVVLVVGSKNSSNSNRLAELAQRAGKLARLIDSAEDIQEAWVKGVSCVGVTAGASAPDILVQQVIQRLNELGGVDAVELIGREENIIFEVPKELRVEVKQLD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: HIS7_MAGO7
Sequence: MASPRWAALARDTNETKVKLALSIDGGDLPPDTHPSLLEAAASGHASQSSSSQKISINTGIGFLDHMLHAFAKHAGFSLLLTCQGDLHIDDHHTAEDVCIALGDAFKTALGSAAGIARFGFAYCPLDEALSRAVVDVSNRPFAVVELGLRREKIGDLSCEMIPHCIMSFATAARLTIHVDCIRGENDHHRAESAFKALAVAVRTAVGKVAGREGEVPSTKGTLSV
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
Protein: RL1_HYPNA
Sequence: MATKGKRARAIEQTVDKTKAYSVSEAVKLVKSNAKAKFDESIEIAINLGVDPKYADQQVRSVVNLPAGTGKTIRVAVFAKDKKAEEALAAGADIVGADDLFEKVNGGFMDFDRVIATPDMMGLVGRLGKVLGPRGLMPNPKVGTVTPNVAQAVKDAKGGAVEFKVEKAGIVHAGVGKASFSDADIEKNVQAFISAVVKARPSGAKGTFVRKVTLSSTMGTGVAIDLAEAKS
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: DESA1_MYCTU
Sequence: MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSKLSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSVLYVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEFRRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR
What is the function of this protein?
May be a desaturase involved in mycobacterial fatty acid biosynthesis.
What are the official names of this protein?
Putative acyl-[acyl-carrier-protein] desaturase DesA1, Putative acyl-ACP desaturase DesA1.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 2 family.
What are the subcellular locations of this protein?
Cell surface.
Protein: TRUA_SALDC
Sequence: MSGQQSSPVYKIALGIEYDGSKYYGWQRQNEVRSVQEKLEKALSQVANEPINVFCAGRTDAGVHGTGQVVHFETTALRKDAAWTLGVNANLPGDIAVRWVKTVPDDFHARFSATARRYRYIIYNHRLRPAVLAKGVTHYYEPLDAERMHRAAQCLLGENDFTSFRAVQCQSRTPWRNVMHINVTRHGPYVVVDIKANAFVHHMVRNIVGSLLEVGAHNQPESWIAELLAARDRTLAAATAKAEGLYLVAVDYPDRFDLPKPPMGPLFLAD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: HEM6_VIBCH
Sequence: MESIVDKQAVKHFLLQLQDKICQQLEATDGQAQFIEDAWQREPGEKLGGGGRTRVMREGAVFEQGGVNFSHVFGEQMPASATAHRPELAGRRFEAMGVSLVMHPKNPYVPTSHANVRFFIAEKEGEAPIWWFGGGFDLTPFYPFVEDGQHWHQTAKNICAPFGSEIYNEHKAWCDRYFYLPHRNETRGIGGLFFDDLNEWSFEQCFAYMQAVGEGYTQAYVPIVEKRKNTPFTERERQFQLYRRGRYVEFNLVLDRGTLFGLQTGGRTESILMSMPPLARWEYAYQPQAGTPEAKLSEFLVPREW
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1776_POLSJ
Sequence: MSTSSESALSVFGAGDINNAAYVRSIIRQGRWTSHTSGLASEHVQGNVVILPADEANDFLRYCQRNPKPCPLLAVSEPGHAGLPTLGADLDIRTDLPRYRVWRHGEVVDEPADISALWRKDLVTFVIGCSFSFEEALMQAGLPLRHIEQQRNVAMYRSNIATEPAGAFHGPMVVSMRPFKASDAIRAIQITSRFPDVHGAPVHMGDPAQIGIADLARPDYGDAVEVLPDEIPVFWACGVTPQAAIAQARPEFCITHAPGAMLITDLLNHQLAAF
What are the official names of this protein?
Putative hydro-lyase Bpro_1776.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: PSA3_SPIOL
Sequence: MSSIGTGYDLSVTTFSPDGRVFQIEYAAKAVDNSGTAVGIKCKDGIVLGVEKLIQSKMMLPGSNRRIHSVHRHSGMAVAGLAADGRQIVARAKSEATNYESVYGEAVPVKELADRVASYVHLCTLYWWLRPFGCGVILGGYDRDGPQLYMVEPSGISYRYFGAAIGKGKQAAKTEIEKLKLSEMTCREGIIEVAKIIYKVHDEAKDKAFELEMSWICDESKREHQKVPDNLLQEAKAAATAALEEMDAD
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit alpha type-3, 20S proteasome alpha subunit G, 20S proteasome subunit alpha-7, Proteasome component C8.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.