PharMolix/UniProtQA huggingface dataset:
Protein: FP1V2_PERVI
Sequence: MARNMNILTLFAVLLGSASAVYHPPSWTAWIAPKPWTAWKVPPPAWTAWKAHPPAWTAWKATPKPWTAWKAPPPAWTAWKATPKPWTAWKAPPPTWTAWKATPKPWTAWKAPPPVWTAWKATPKPRTAWKAPPPTWTAWKAAPKPWTAWKATPKPWTAWKAPPPAWTAWKATPKPWTAWKATPKPWTAWKATPKPWTAWKATPKPWTVWKATPKPWTAWKAPPPAWTAWKATPKPWTAWKAPPPAWTAWKATPKPWTAWKAPPPAWTAWKATPKPWTAWKATPKPWTAWKATPKPWTAWKATPKPWTAWRATPPPTWTAWHGHGYGGYGKPGKPGKPGSKGPRGPAGPPGATGKTGRTGATGKRGPPGYPGKPGVPGRNGYVHIVFDGYGKWEIGKIERKNIREAVAKAWTAWNAGHGHGWTAWTAPPAYG
What is the function of this protein?
Provides adhesiveness to the mussel's foot.  Mussels produce one of the strongest water insoluble glues.  The mussel's adhesive is a bundle of threads, called a byssus, formed by a fibrous collagenous core coated with adhesive proteins (By similarity).
What are the official names of this protein?
Foot protein 1 variant 2.
What are the subcellular locations of this protein?
Secreted.
Protein: E1170_IXORI
Sequence: MELKTFAFLQIAAFIALGVQIFFVGTDALGDEDQLFSVEYCGTNCTQQDDGKWTPCSGKNGKCKCYHEDGKRYGLCLYTEYTDFSQYPNPEGSEIENTRPRP
What is the function of this protein?
Salivary chemokine-binding protein which binds to host chemokines CXCL1 and CXCL8.
What are the official names of this protein?
Evasin P1170.
What are the subcellular locations of this protein?
Secreted.
Protein: FRE3_NYCIN
Sequence: MHFLKKSIFLVLFLGLVSLSICEKEKREDQNEEEVDENEEESEEKRGLMSVLGHAVGNVLGGLFKPKS
What is the function of this protein?
Antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria (PubMed:9225251).  Antibacterial activities have been tested against Bacillus cereus (MIC=12. 5 ug/ml), Escherichia coli (MIC=50 ug/ml), Leuconostoc mesenteroides (MIC=25 ug/ml), Micrococcus luteus (MIC=1. 5 ug/ml), Pastewella haemolytica (MIC=0. 8 ug/ml), Staphylococcus aureus (MIC<l00 ug/ml), Streptococcus faecalis (MIC<150 ug/ml) and Streptococcus uberis (MIC=50 ug/ml) (PubMed:9225251).  Strongly inhibits the formation of NO by neuronal nitric oxide synthase (nNOS) at micromolar concentrations (PubMed:11784303).  Acts by a non-competitive mechanism, probably by binding to calcium/calmodulin and as a consequence blocking calmodulin attachment to nNOS (PubMed:11784303).
What are the official names of this protein?
Frenatin-3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Frenatin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CAF17_ASPNC
Sequence: MRSSPSTRTICAQCLSRNRHFSTTIQRCAPRSSTPNPPSPPATGYARLTNRGLISITGIDSTSYLQGLITQNMLITNDPNRPTRRTGSYTAFLNSQGRVLNDAFLYPLPQAEGTSPDEHAWLVEVDKSEVTSLLKHLKKHKLRAKLKLRALDEGERTVWASWKDHSEPRWAAYNLDSQSFSPFASSSATVTGCVDTRAPGFGSRLITPGEGDLTTHLAGAEGEGYGSEVDLGSYTVRRMLHGVAEGQSEIIRESALPLESNMDMMRGIDFRKGCYVGQELTIRTHHTGVVRKRILPVQLYEGSLGDLESADMPVYDPSVEVELPPSGSNISKVSARKGRSAGKFLGGVGNIGLALCRLEMMTDVALTGEGTQYSPDQEFKVSWTGAEDGSSESGEVKLKALVPAWTREYISNGGVKKNQGRNLELEGQRARELLEQLEEEESSR
What are the official names of this protein?
Putative transferase caf17, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the GcvT family. CAF17 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GPMI_PSEA7
Sequence: MTATPKPLVLIILDGFGHSESPDYNAIYAAKKPVWDRLLATQPHGLISGSGMDVGLPDGQMGNSEVGHMNLGAGRVVYQDFTRVTKAIRDGEFFDNPVIASAVDKAVAADKAVHILGLLSPGGVHSHEDHLVAMAQMAARRGAGKIYLHAFLDGRDTPPKSAQPSLERLDATFAGLGKGRIASIIGRYFAMDRDNRWDRVQAAYELIVDGKAEFTADSSVAALEAAYARGESDEFVKATAVVPAGAEAVRVEDGDAVIFMNFRADRARELSRAFVEPAFGEFPRQRAAQLAGFVMLTQYAASIPAPCAFPPEPLTNVLGEYLAKHGKTQLRIAETEKYAHVTFFFSGGREEPYEGEERILIPSPKVATYDLQPEMSAPEVTDRIVEAIEQQRYDVIVVNYANGDMVGHTGVFEAAVKAVECLDTCMGRIVEALDKVGGEALITADHGNVEQMEDESTGQAHTAHTCEPVPFVYVGKRKLSIREGGVLADVAPTMLTLMGLEQPAEMTGRSIVILD
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: PANE_STRP6
Sequence: MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGLVVTGDVEETVKLPIMKPTEATQEADLIILFTKAMQLPQMLQDIKGIIGKETKVLCLLNGLGHEDVIRQYIPEHNILMGVTVWTAGLEGPGRAHLQGVGALNLQSMDPNNQDAGHQVADLLNKANLNATYDENVVPNIWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEIIHEFVIVGQAEGVELNEEEITQYVMDTSVRAAHHYPSMHQDLVQNHRLTEIDFINGAVNTKGEKLGINTPYCRMITELVHAKEAVLNIQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
What are the official names of this protein?
2-dehydropantoate 2-reductase, Ketopantoate reductase, KPR.
What is the protein family that this protein belongs to?
Belongs to the ketopantoate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMHR2_HUMAN
Sequence: MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRCCFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPTILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV
What is the function of this protein?
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.  Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.  Receptor for anti-Muellerian hormone.
What are the official names of this protein?
Anti-Muellerian hormone type-2 receptor, Anti-Muellerian hormone type II receptor, AMH type II receptor, MIS type II receptor, MISRII, MRII.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RS4_NITEC
Sequence: MARNINPKCRQCRREGEKLFLKGDKCFSDKCPIERRNYPPGQHGQRKTRLSDYAVQLREKQKIRRIYGLLENQFRNVYKRADRQKGITGENLLKLLESRLDNVAYNMGFGASRAEARQIIRHDCILLNGKKANIPSQLIGPGDQIEVAEHAKSYLRIKSSIELAKRRSIPSWLEVDFDNLKGLYKNKPDRSDLSSTINESLVVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SET_MOUSE
Sequence: MAPKRQSAILPQPKKPRPAAAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD
What is the function of this protein?
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning.  Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1.  In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition.  Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A.  Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases.  The predominant target for inhibition is histone H4.  HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA.  Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity).
What are the official names of this protein?
Protein SET, Phosphatase 2A inhibitor I2PP2A, I-2PP2A, Template-activating factor I, TAF-I.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium (By similarity).
Protein: SSRP_SYNJB
Sequence: MAVDPNVKTLVDNRRARFEYDILETYEAGIQLTGTEVKSIRAGKANLQDAFALFRDGEAWLHNLHISPHDTASKVFNHDPTRRRKLLLHRREIDRLRGLVEQKGLTVVPLKLVLNRGWIKAHLGVARGKKLHDKRQAIKERQTQREIQRELKER
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CDN2B_RAT
Sequence: MLGGGSDAGLATAAARGQVETVRQLLEAGADPNAVNRFGRRPIQVMMMGSAQVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLMVLHKAGARLDVCDAWGRLPVDLAEEQGHRDIARYLHAATGD
What is the function of this protein?
Interacts strongly with CDK4 and CDK6.  Potent inhibitor.  Potential effector of TGF-beta induced cell cycle arrest (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 4 inhibitor B, p14-INK4b, p15-INK4b.
What is the protein family that this protein belongs to?
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Protein: TRX2_HCMVA
Sequence: MAAMEANIFCTFDHKLSIADVGKLTKLVAAVVPIPQRLHLIKHYQLGLHQFVDHTRGYVRLRGLLRNMTLTLMRRVEGNQILLHVPTHGLLYTVLNTGPVTWEKGDALCVLPPLFHGPLARENLLTLGQWELVLPWIVPMPLALEINQRLLIMGLFSLDRSYEEVKAAVQQLQTITFRDATFTIPDPVIDQHLLIDMKTACLSMSMVANLASELTMTYVRKLALEDSSMLLVKCQELLMRLDRERSVGEPRTPARPQHVSPDDEIARLSALFVMLRQLDDLIREQVVFTVCDVSPDNKSATCIFKG
What is the function of this protein?
Structural component of the T=16 icosahedral capsid.  The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes.  These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2.  Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.
What are the official names of this protein?
Triplex capsid protein 2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae TRX2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: PUR5_CUPTR
Sequence: MSASPTAGQAGLSYRDAGVDIDAGDALVDRIKPFAKRTMREGVMAGIGGFGALFELSKKYQEPVLVSGTDGVGTKLKLAFQLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVIQGIARGCELAGCALIGGETAEMPSMYPDGEYDLAGFAVGAVEKKKIIDGSTITPGDVVLGLASSGAHSNGYSLVRKIIEVAKPDLDADFHGQRLQDAIMAPTRIYVKPLLSLIETLPVKGMAHITGGGLTENVPRVLAQDVTAVLHRDAWTLPPLFQWLQAQGRVADDEMHRVFNCGIGMVVIVAKEDAERAIRHLQAAGEAVWQIGEIRERAEGEAQTIVI
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1222_MYCLE
Sequence: MTEHCASDISDVSCPPRGRVIVGVVLGLAGTGALIGGLWAWIAPPIHAVVGLTRTGERGHDYLGNESEHFFVAPCLMLGLLTVLAVTASVLAWQLRQHRGPGMVIGLAIGLMICAATAAAVGALLVWMRYGALNFDAVPLSYDHKVAHVIQAPPVFFAHGLLQVAATVLWPAGIAALVYAVLAAANGRDDLGGRLCSR
What are the official names of this protein?
Uncharacterized protein ML1222.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1591.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MHPD_PARP8
Sequence: MSDDNRIESMAARLREAQSSRQTIAPLREACPEGDATLAYAIQQVNNDLRAANGERLVGRKIGLTSPAVQKQLGVGQPDFGALFASMAYGDSQPMPLASLVQPKVEAEIALVLERDLTAEKNTFADLIGATAYALAAIEVVDSRIRDWDIRFFDTVADNASSALFVLGSRPVLLRDIDLTACAMTLTQDGEILSRGNGTACLGNPLNAAAWLADRMVRLGTPLRAGDIVLTGALGPMVAVKAAGTYTAHIEGLGSVRASFSE
What is the function of this protein?
Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.
What are the official names of this protein?
2-keto-4-pentenoate hydratase, 2-hydroxypentadienoic acid hydratase.
What is the protein family that this protein belongs to?
Belongs to the hydratase/decarboxylase family. MhpD subfamily.
Protein: RSGA_HAMD5
Sequence: MKKNKLSKNQHRRIQAHHQYRLHPTSLTDDKNNQLDDAQFGEPQQGVVISRFGQHADVEGHQGQQQRCHIRRNVLSLVTGDRVIWRPGIPRQENRNVKGIVEAVHERKSVLTRPDFYDGIKPMAANIDQIVIVSAVIPDLSLNMIDRYLVVSESLNIKPLLLLNKIDLLTPNERKKINLRLNIYRNIHYTVLEVSAQTGEGIADLQANLLDRVSIFSGQSGVGKSSLLNTLLPPTEQQILVEALSEKSALGQHTTTTSRLYHFQQGGDLIDSPGIREFGLWHLTQEQIIQGFIEFRDYVGHCKFRDCAHIDDPCCALRDAVQKGHIAKERFDNYHQILSEITLKGKKLFNQD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHC_STRRD
Sequence: MRSWSAPKVPRLPGVGAPLRLFDTAAGEVGPTQPGPTARLYVCGITPYDATHLGHANTYLAFDLVNRLWRDAGHEVHFTQNATDVDDPLLERAEQTGQDWRELAEREIELFRTDMEALRILPPREYVGVTEVIDQVAELIELLRDKGATYDLDGDLYFDVAAAPKFGAVSGYSEERMLDLFGQRGGDPDRAGKKHPLDWLLWRAERPGEPSWPSPFGQGRPGWHIECTAIALANLGSGFDVAGGGSDLIFPHHECGAHEGHVACGEWPFAKAYVHAGMVALDGEKMSKSKGNLVFVSRLRKEADPMAIRLALLAHHYRSDWEWTADQLASAEVRLARWRSAVGLPAGPEAETVLAELRARMTDDLDAPGALAVVDAWADRALAGGGTDPGAPALVRDIVDALLGVEL
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: DER_POLNA
Sequence: MKPVIALVGRPNVGKSTLFNRLTKTRDAIVADFAGLTRDRHYGNGKLGPHEYIVIDTGGFEPDAVTGIYKEMARQTRQAVAESDVVIFVVDARAGISAQDYDIANYLRKLGKPTVLAANKAEGLPEGTQVSEFFELGLGEMLAVSASHGQGMRMLVDLALAPLNLPDPAEETEQEDPAVIKLAVAGRPNVGKSTLINTWLGEERLVAFDLPGTTRDAISVPFEHAGQKFELIDTAGLRRKGKVFEAIEKFSVVKTLQAIENANVVLLLLDATQGVTDQDAHIAGYILESGRAVVLAVNKWDAVDAYQRELLQRSIETRLGFLKFASIHHISAIKRQGLGPVWKSIIQAHASANRKMSTPVLTRLLMEAVQFQQPQRSGVFRPKLRYAHQGGMNPPIVIIHGNSLDHVTESYKRYLEGRIRKEFDLVGTPLRIQLKSSVNPFKDKE
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: TAL2_STRCO
Sequence: MTDALKRLSDEGVAIWLDDLSRKRITSGNLAELIDQQHVVGVTTNPSIFQKAISQGDGYDQQLADLAVRGVTVEEAIRMITTADVRDAADILRPVYDNTGGKDGRVSIEVDPRLAHNTHATVAEAKQLAWLVDRPNTFIKIPATEAGLPAIAETIGLGISVNVTLIFSLERYRKVMDAFLTGLEKAKERGLDLSQIHSVASFFVSRVDTEIDKRIDALGTDEAKAQRGKAAVANARLAYQAYEEVFGTDRWAALEKAGANKQRPLWASTGVKDKAYSDTMYVTDLVAPNTVNTMPEATLLATEDHGEITGDAVAGSYERARADLDAIEKLGISYDEVVQLLEKEGVDKFEDAWNDLLKSTEAELKRLAPSKG
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase 2.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPRK_BACMK
Sequence: MPKVRTKDLIEQFQLELVSGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTTEQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGVPLLRSAQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDTLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue.  Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: DEF_STRTD
Sequence: MDAQTKIIRASHMIDMNDIIREGNPTLRAVAEDVTLPLSDEDIILGEKMMQFLRNSQDPVIAEKMGLRGGVGLAAPQLDISKRIIAVLVPNPEDAKGNPPKEAYSLQEIMYNPKVVAHSVQEAALGNGEGCLSVDRDVPGYVVRHARVTIEYFNKEGEKKRIKLRGYDSIVVQHEIDHTNGIMFYDRINKDNPFTIKDGLLIIE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: PNP_GLUOX
Sequence: MFDYFRKEIEWAGRPLILETGKVARQADGAVMITYGDTVVLCTAVGAKSVKPGQDFFPLTVNYQEKAYAAGKIPGGFFKREGRPSEAEVLNARLIDRPIRPLFPENFRNEVQITATVLSYDNENDPALVSLIGCSAALTLSGIPFFGPVACARIGRIDGKLVVNPTHDEIKDSTLDLMVAGTAEGVLMVESEASELSEETMLEAVTLGHTSFQPVIDAIIALAEHAAKAPWDLPSLTKEEIALRKRVEKVGNKLMADAYKERQKQARYKKVAEAKDRINEILADEGLDVELAKPMLKELEAQVVRGSILKTGIRIDGRDLKTVRPILAEVGILPRAHGSSLFTRGETQALVVATLGTGQDEQIIDALEGEYRSNFMLHYNFPPYSVGECGRMGSPGRREIGHGKLAWRAIHPLLPSKEAFPYTMRVVSEITESNGSSSMATVCGSSLALMDAGVPLPRPVAGIAMGLIKEDRGYAVLSDILGDEDHLGDMDFKVAGTADGVTALQMDIKITSITPEIMKIALEQAREGRIHILGEMAKALTEGRGEVSGNAPKITTISVPKEKIRDVIGSGGKVIREIVEYSGAKVDIGDDGTVTIAASNDEQAQKAIARIEGIVAEPEIGRIYEGKVVKTADFGAFVNFLGPRDGLVHISELAEGRVAKTSDVVKQGDAVKVKVIGFDDRGKVKLSMRVVDQATGADITESVGAKPGRPPRRDAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1932_STAA2
Sequence: MAVNLYDYANQLEQALRESEEYKAIKEAFANVKANEESKKLFDEFRETQINFQQKQMQGEEIAEEDLQKAQEQAQAIEKDENISALMNAEQKMSQVFQEINQIIVKPLDEIYAD
What are the official names of this protein?
UPF0342 protein SaurJH1_1932.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: ACTC_MOUSE
Sequence: MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, alpha cardiac muscle 1, Alpha-cardiac actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RUVB_NEIMB
Sequence: MLQTDNLTAAQPQRIVAAQTASAQEELLERALRPKTLDDYIGQDKAKEQLAIFIQAAKKRGEALDHVLLFGPPGLGKTTLAHIIAKELGVNLRQTSGPVLERAGDLAALLTNLDPHDVLFIDEIHRLSPVVEEILYPALEDYRLDIMIGEGPAARSVKIDLPPFTLIGATTRAGMLTNPLRDRFGIVSRLEFYENRDLTTIVSRSAQLLQLDMSEEGAEEIAKRSRGTPRIANRLLRRVRDFADVKNNGTIDGGIADAALSMLDVDAQGLDVMDRKFLEAVLHKFGGGPVGLDNVAAAIGESTDTIEDVIEPYLIQQGFLQRTPRGRMATERAYLHFGLPVEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: YCEH_BACSU
Sequence: MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDVKNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEPKGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNIKYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYDLDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVADSMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQIEEENKRLREDGARRIAQLQDNIKKAALQQ
What are the official names of this protein?
Uncharacterized protein YceH.
What is the protein family that this protein belongs to?
Belongs to the TelA family.