PharMolix/UniProtQA huggingface dataset:
Protein: PYRG_SALTY
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQLAVDIGREHALFMHLTLVPYLAAAGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISMKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIYEEANPAGEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVTVNIKLIDSQDVETRGVEILKDLDAILIPGGFGYRGVEGKIATARYARENNIPYLGICLGMQVALIEFARNVAGMDNANSTEFVPDCKYPVVALITEWRDEDGNVEVRSEKSDLGGTMRLGAQQCQLSDDSLVRQLYGASTIVERHRHRYEVNNMLLKQIEAAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAANEHQKRQAK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: Y2993_MYCBP
Sequence: MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAPPVGKYVDAWGGMIQSRGEGHARSIGVSNFTAEHIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTRVREDPLTYAGT
What are the official names of this protein?
Uncharacterized oxidoreductase BCG_2993.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: PTBP1_MOUSE
Sequence: MDGIVPDIAVGTKRGSDELFSTCVSNGPFIMSSSASAANGNDSKKFKGDNRSAGVPSRVIHVRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGAPGIMSASPYAGAGFPPTFAIPQAAGLSVPNVHGALAPLAIPSAAAAAAASRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGSQAQLAMSHLNGHKLHGKSVRITLSKHQSVQLPREGQEDQGLTKDYGSSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEDDLKSLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIELHNHDLGENHHLRVSFSKSTI
What is the function of this protein?
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events.  Activates exon skipping of its own pre-mRNA during muscle cell differentiation.  Binds to the polypyrimidine tract of introns.  May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA.  May promote the binding of U2 snRNP to pre-mRNA.  Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.  Represses the splicing of MAPT/Tau exon 10.  Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9.  Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.
What are the official names of this protein?
Polypyrimidine tract-binding protein 1, PTB, Heterogeneous nuclear ribonucleoprotein I, hnRNP I.
What are the subcellular locations of this protein?
Nucleus.
Protein: CDD_HAEIG
Sequence: MQELIKRTLPQDDALNQAIVNELRSQNWAGFLNYSQVQQLCHNFELTTLKLAMHLLPLAASYSHTAISHFNVGAIAIGEQGDFYFGANQEFANSAIQQTIHAEQSAISHAWLRNERRISDMVVNYTPCGHCRQFMNELHGAEKISIHLPHSQNNPLHSYLPDAFGPKDLDIAAHLLAEENHDLVADHQDDLVNQAILAANQSHCPYSNSPHGIAILFKNGDVVTGRYAENAAFNPSLPALQTALNFAYLNDRKLSDIERIVMAEKALKLSHKTMAETLLSTLTSVELEYYSL
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: CINA_CLOB6
Sequence: MKAEILCVGTELLLGDIVNTNAQYISKELANIGIEVYHHSVIGDNENRLLKELERAFNYCDLVITTGGLGPTKDDLTKESVAKFFQEDLVLHEKSLKQIEKRLSCFNKSMTESNRKQAYFPKNCEILENPNGTAPGFIIEKDNKIAIILPGPPYEMQPMFENKVIPYLEKLTNSTIKSKVLRITGIGESDVADLISDILESQTNPTVAPYAKQGETTLRITAKANSEEKALSLIVPIEKKIRQILGDNIYGSGETLLEEVVANILVKRNLTIATAESCTGGLLAGKLINFPGISSVFLEGAITYSNESKINRLNVKKETLEKYTAVSKEVALEMAEGIAKSAGTNIGISTTGVAGPGGGTYDKPIGLIYIGLYINGKTFVEELNYSGNRQFIRNITVTRALDFLRRNLE
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: LPXC_ECOLC
Sequence: MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: CARA_STRA3
Sequence: MKRLLLLEDGSVFEGEAFGADVETSGEIVFSTGMTGYQESITDQSYNGQIITFTYPLIGNYGINRDDYESIRPTCKGVVIYEWAEYPSNWRQQMTLDEFLKLKGIPGISGIDTRALTKIIRKHGTMKACLINEGNSIHEALENLQKSVLLNDQIEQVSTKLAYASPGVGKNIVLVDFGLKHSILRELSQRQCHITVVPHTTTAQEILNLNPDGVLLSNGPGNPEQLPNALQMIQEIQGKIPIFGICMGHQLFAKANGAKTYKMTFGHRGFNHAVRHLQTGQVDFTSQNHGYAVSREDFPEALFITHEEINDKTVEGVRHKYYPAFSVQFHPDAAPGPHDTSYLFDEFINMIDDFQQKS
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: AROC_YERPY
Sequence: MAGNSIGQFFRVTTFGESHGIALGCIIDGVPPGIPITEADIQLDLDRRRPGTSRYTTQRRELDQVRILSGVFEGVTTGTSIGLMIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGVRDYRGGGRSSARETAMRVAAGAIAKKYLAQKFGVQVRGYLAQMGDVSCDLLDWDLVEQNPFFCPDASKLEPLDALMRELKKAGDSIGAKITVVAENVPVGLGEPVFDRLDADLAHALMSINAVKGVEIGDGFAVVTKRGSENRDEITPQGFQSNHAGGILGGISSGQPVVAHIALKPTSSIMVPGQTINRQGEAVEMVTRGRHDPCVGIRAVPIAEAMMAIVLMDHLLRQRAQCGDVASDVPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: YHBP_SALPK
Sequence: MDTLTAIGRWLAKQHVVTWCVHHEGELWCANAFYLFDAQNVALYLLTDDKTRHAQMSGACASVAGTVNGQPKTVARIRGVQFKGEIRRLEGQESDAARKAYLRRFPVARGLPAPVWEIRLDEIKFTDNTLGFGKKLHWLRDSRAQQA
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: MAP12_MYCTU
Sequence: MPSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).  Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
What are the official names of this protein?
Methionine aminopeptidase 2, MAP 2, MetAP 2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Protein: SFSA_DESHY
Sequence: MKYTNIREGQFLSRPNRFIAKVEIDGKEEICHVKNTGRCRELLIPGVTVFLQEADFEHRKTKYDLIGVRKGNRLINMDSQVPNKVFCEWLEKGYFQELQHIKQEQTFRNSRFDFYLEAGQRKIFVEVKGVTLEEEGVALFPDAPTERGVKHLRELSQAVAAGYEAYVVFIIQMKDIHYFTPNIKTHQAFGDALIQADKQGVKILALDCEVTEDSIEAGDFVTVKLVEG
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: Y1302_METJA
Sequence: MVIELAELKNFAKIFLTGIYENLERIIFGSGRYTSLEMRNAILTGTVKIPKTVIEELCIGCEGCANVCPTKAIEMIPIEPVKITDNYVKDKIPKINPEKCVYCLYCHDFCPVFSVFNEISPIHPRDVGEEYIEIDISKLLQKKIEISEEQINKISSLLSINLRRIIKD
What are the official names of this protein?
Uncharacterized polyferredoxin-like protein MJ1302.
Protein: KTHY_JANMA
Sequence: MTTGKFITFEGIDGAGKSTHLSFVAELLCERKKTVVVTREPGGTSLGEELREILLHEKMHLETEALLMFAARREHIAQVIAPALERGDWVISDRFTDATFAYQGGGRKLDRAKLNALEQWVHPHLQPHLTLLFDVPLDVARARLDATRTLDKFEQEKAEFFAATRAEYLRRAAEFPQRFHVIDSTRSIAAIQEQLRAIVAGIDS
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: NUOH_PSEMY
Sequence: MNWLTPELIEILVAVLKAIVILLAVVVCGALLSFVERRLLGWWQDRYGPNRVGPFGMFQIAADMIKMFFKEDWTPPFADRFIFVLAPMIAFAAMLMAFAIIPITPTWGVADLNIGILFFFAMAGLSVYAVLFAGWSSNNKFALLGSLRASAQTISYEVFLALALMGVVAQVGSFNMRDIVDYQAQNLWFIIPQFFGFCTFFIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFVGEYVGIVTISALLVTLFFGGWHGPFGLLPQIPFFWFALKTAFFIMIFILLRASIPRPRYDQVMAFSWKFCLPLTLINLLVTGALVLAAAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CDC26_DICDI
Sequence: MINRKPTRIELNMEDIEEYEQLKKEQTNSYKQQQQQQQPTTISTPKQYPLLNTTQPPKKTTAQIIGYDQ
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
What are the official names of this protein?
Anaphase-promoting complex subunit cdc26, Cell division cycle protein 26 homolog.
What is the protein family that this protein belongs to?
Belongs to the CDC26 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UPPP_PSYCK
Sequence: MDIILLIQAVIMGIVEGITEFLPISSTGYLILSADLMGFWTKEKVDLFVVVVQFGAILAVIYDYWGRLWQALMGLLTGKAEGMSNPRQLGLSLIVATIPVMIVGFTFADEIKAYLFNPIVVAIMLIIGGLLIFYVENRPKAIIAEEAEDVSLKTALMIGLLQCLALIPGTSRSGATIIGALWLGVSRKASAEFSFFLGIPVIIGAALLDFIKHRDVLTSSEDWLVLGIGTVVSFIIALLCIRLLVAWVSRRDFKIFAWLRIITGVLVLIAAWGFGYQMAG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPT5_YEAST
Sequence: MSDNSDTNVSMQDHDQQFADPVVVPQSTDTKDENTSDKDTVDSGNVTTTESTERAESTSNIPPLDGEEKEAKSEPQQPEDNAETAATEQVSSSNGPATDDAQATLNTDSSEANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDDDEDDDDEAPTKRRRQERNRFLDIEAEVSDDEDEDEDEEDSELVREGFITHGDDEDDEASAPGARRDDRLHRQLDQDLNKTSEEDAQRLAKELRERYGRSSSKQYRAAAQDGYVPQRFLLPSVDTATIWGVRCRPGKEKELIRKLLKKKFNLDRAMGKKKLKILSIFQRDNYTGRIYIEAPKQSVIEKFCNGVPDIYISQKLLIPVQELPLLLKPNKSDDVALEEGSYVRIKRGIYKGDLAMVDQISENNLEVMLKIVPRLDYGKFDEIDPTTQQRKSRRPTFAHRAPPQLFNPTMALRLDQANLYKRDDRHFTYKNEDYIDGYLYKSFRIQHVETKNIQPTVEELARFGSKEGAVDLTSVSQSIKKAQAAKVTFQPGDRIEVLNGEQRGSKGIVTRTTKDIATIKLNGFTTPLEFPISTLRKIFEPGDHVTVINGEHQGDAGLVLMVEQGQVTFMSTQTSREVTITANNLSKSIDTTATSSEYALHDIVELSAKNVACIIQAGHDIFKVIDETGKVSTITKGSILSKINTARARVSSVDANGNEIKIGDTIVEKVGSRREGQVLYIQTQQIFVVSKKIVENAGVFVVNPSNVEAVASKDNMLSNKMDLSKMNPEIISKMGPPSSKTFQQPIQSRGGREVALGKTVRIRSAGYKGQLGIVKDVNGDKATVELHSKNKHITIDKHKLTYYNREGGEGITYDELVNRRGRVPQARMGPSYVSAPRNMATGGIAAGAAATSSGLSGGMTPGWSSFDGGKTPAVNAHGGSGGGGVSSWGGASTWGGQGNGGASAWGGAGGGASAWGGQGTGATSTWGGASAWGNKSSWGGASTWASGGESNGAMSTWGGTGDRSAYGGASTWGGNNNNKSTRDGGASAWGNQDDGNRSAWNNQGNKSNYGGNSTWGGH
What is the function of this protein?
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing.  This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
What are the official names of this protein?
Transcription elongation factor SPT5, Chromatin elongation factor SPT5.
What is the protein family that this protein belongs to?
Belongs to the SPT5 family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion. Chromosome. Note=Associates with the coding region of HTA1.
Protein: HTPX_ALIF1
Sequence: MKRIALFLATNLAVMIVFSIVLNIVYAVTGIQQGSLSGLLVMAVLFGFGGSLISLMMSKSMALRSVGGEVIEQPRNETEHWLLETVSRQAQQVGIGMPTVAIYDSPDMNAFATGAKRDDSLVAVSTGLLHSMTRDEAEAVLAHEVSHIANGDMITMTLMQGVVNTFVIFLSRMIANAVSGFTSSDEEGEGEGGSFMTYFIVSTVLELAFGFLASFLTMWFSRHREFHADAGAAQLVGKQKMIAALERLRMGQESQLEGSMMAFGINGKKSLTELLMSHPPLEKRIDALRQM
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PHEA_METJA
Sequence: MNKAVIYTLPKGTYSEKATKKFLDYIDGDYKIDYCNSIYDVFERVDNNGLGVVPIENSIEGSVSLTQDLLLQFKDIKILGELALDIHHNLIGYDKNKIKTVISHPQALAQCRNYIKKHGWDVKAVESTAKAVKIVAESKDETLGAIGSKESAEHYNLKILDENIEDYKNNKTRFILIGKKVKFKYHPKNYKVSIVFELKEDKPGALYHILKEFAERNINLTRIESRPSKKRLGTYIFYIDFENNKEKLEEILKSLERHTTFINLLGKYPVFD
What are the official names of this protein?
Prephenate dehydratase, PDT, MjPDT.
Protein: LEU1_SHEB5
Sequence: MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESKLKRSFDQVLEMAVSAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAILAGARTINIPDTVGYTVPSEFGTIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEHDYNMDALYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQSDSTEGVATATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGVGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQSMQKNRELGGV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: PSB1_ENCCU
Sequence: MMSNEKEMTGTTIIAIKYDDGVLIGADSRTSMGAYVSSRVTDKLTQITDKIFVCRSGSSADTQMISSYLRMYLSMYSQLEDSIPQVQRAAALASKIIYENPSLLAGLIVAGYDDKPRVFNISLGGSLTERDWAIGGSGSAFIYGYCDVNWRSGMSLEEGIRFVRNAVSCAINRDNASGGCIRMSAISRTGVQRYFYPGDKVLQ
What is the function of this protein?
The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus.  It is essential for the regulated turnover of proteins and for the removal of misfolded proteins.  The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  It has an ATP-dependent proteolytic activity (By similarity).
What are the official names of this protein?
Probable proteasome subunit beta type-1, 26S proteasome beta-type subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AK_RICBR
Sequence: MALIIQKFGGTSVTTIDRIKKIIPIIKAEIAKNNQVIIVVSAMAGVTNQLVTLCNEVSSLNKSSQLAEYDVALSSGEIVTASLLALALQEENINARSFLAWQLPILTDDNHSKALVESVDTNLLNECLQQNIIPIIAGFQGINKHNRLATLGRGGSDTTAALIAAAMKADRCDIYTDVEGVFAADPRIIPKAKKIDEIDFSEMLELALSGAKVLHSRAAEIVMRYQIDMRILSTFAPEAGCTLITSKDKIMEKRIISGITSNKNLLYITIESSSLNFIQVASIIAQNNNHIEVMQEIEPNKRYSFITNLTDKNSLHILLTNLKNNNQISNFTFDTEIATVSIIGHGIKNDLKLLEVILSKLAKDNINVQMVQISEIKIILLINDKQVEKTVLDLYDLLKISETGHC
What are the official names of this protein?
Aspartokinase, Aspartate kinase.
What is the protein family that this protein belongs to?
Belongs to the aspartokinase family.
Protein: SYS_PHYMT
Sequence: MLNLKFIIENIEKVIEKLNTRTGDFSYLNKLLVLNIKKKKLIFNIETLRYQQNKISKEISILKQNKTNTENIFERSIFLKNEIHVLENDFKKTDSEISEILNNIPNLPHESVILLSKDNNKINFKKYLSPKKFNFNIKDHVTLGRNLNILDFDRASKITGSRFIVYKGLGARLERSLIQFMMDLHSEKGYIEIIPPFIVNDISMFSTGQLPKFKNDSYRLENSNNWYLNPTGEVPAINLHRNEVLSQKNLPLNYVVFTTCFRQEAGTAGKDTRGILRQHQFNKVELIKFTEPQDSYLELENMLQDAESVLQKLELPYRVIMLPSHELGFSASKTYDIEVWLPGSNNYREISSISNTESFQSLRANIKFYSKNKGKNKYVHTLNGSGLAIGRTLIAILENYQNKDGTITVPKVLRSYMRTDIIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMC1_HUMAN
Sequence: MAAAVSSVVRRVEELGDLAQAHIQQLSEAAGEDDHFLIRASAALEKLKLLCGEEKECSNPSNLLELYTQAILDMTYFEENKLVDEDFPEDSSSQKVKELISFLSEPEILVKENNMHPKHCNLLGDELLECLSWRRGALLYMYCHSLTKRREWLLRKSSLLKKYLLDGISYLLQMLNYRCPIQLNEGVSFQDLDTAKLLSAGIFSDIHLLAMMYSGEMCYWGSKYCADQQPENHEVDTSVSGAGCTTYKEPLDFREVGEKILKKYVSVCEGPLKEQEWNTTNAKQILNFFHHRCN
What is the function of this protein?
Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A.  Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy.
What are the official names of this protein?
RAB7A-interacting MON1-CCZ1 complex subunit 1, UPF0600 protein C5orf51.
What is the protein family that this protein belongs to?
Belongs to the RIMOC1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MRAZ_PHEZH
Sequence: MFLSTFEKQLDAKRRIVVPQEFRALAAGPFDGVFCFPSIEADCIEGGGKALFDRYNGVIEELEFGDPLRSALETSVLGGMAKLSFDTAGRITLPESLCDLFGLTDWVTIVGLGDRFQIWEREAFNAHRAAQRELARQGLAELRAQQRAARLAHSGQGSAG
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DEF4_HUMAN
Sequence: MRIIALLAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGSTRGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD
What is the function of this protein?
Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi (PubMed:2500436, PubMed:2501794, PubMed:15317502, PubMed:15616305, PubMed:30658057).  Exhibits antimicrobial activity against Gram-negative E. coli and E. aerogenes and Gram-positive S. faecalis, S. aureus and B. cereus and the yeast C. albicans (in vitro) (PubMed:2500436, PubMed:2501794, PubMed:15317502, PubMed:15616305, PubMed:17088326, PubMed:30658057).  Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B. anthracis anthrax lethal factor lef (PubMed:15620707, PubMed:30658057).  Protects blood cells against infection with HIV-1 (in vitro) (PubMed:15620707).  Inhibits enzymatic activity of B. anthracis lef/anthrax lethal factor (in vitro) (PubMed:30658057).  Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro) (PubMed:2843187).
What are the official names of this protein?
Defensin alpha 4, Corticostatin HP-4, HNP-4, HP-4, Neutrophil defensin 4.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored as mature peptide in neutrophil granules.
Protein: RL20_ECOUT
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NAGB_ECOLC
Sequence: MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMELKVKTLRYFNELEAENIKGL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: ELT6_CAEEL
Sequence: MTSSKEEMPDEMVSREVEEEMEDRVEETATTAAACTGCAQLHKDIRQDVSKMMSKIDEVCGRLEALISEKEKVLLEQMSESGSEEKYPPSPTESRASPSSVGKSNGGCRKRKPTKESVNRHLENGGSDSPFEKITRNISTPVSASSPFPDFQNFNGFVFDPMANPQNMMNLLNLVQQQQHQAAAHHHAQQQAREQKPVKAEESKQQEPSENRNQSPSASVEQTLLDQLSMQFNGKSPSPTVHASTAAAAGSSEDDTSANSSISKCSNCSTIKTTAWRRDLEGKLVCNACGLYYRLHRTHRPVHMRKDFIQQRFRRRMREDENPATSQAAVFSQLLGLPSMANGGANALTFLEQINQLNQSQEQRKSP
What is the function of this protein?
Probable transcription factor (PubMed:11532911).  Involved in embryonic development and in vulval development in larvae, acting redundantly with egl-18 (PubMed:11532911, PubMed:14975731, PubMed:12399309).  Together with egl-18, acts as a downstream target of the Wnt/beta-catenin asymmetry pathway, required to adopt or maintain the seam cell fate (PubMed:23633508).  Required in seam cells, acting redundantly with egl-18, to promote production of alae, expression of several seam-specific genes and maintenance of seam cells in an unfused state (PubMed:11532911, PubMed:23633508).  Plays a role in longevity (PubMed:18662544).
What are the official names of this protein?
Putative transcription factor elt-6, Erythroid-like transcription factor family elt-6.