PharMolix/UniProtQA huggingface dataset:
Protein: CP2CB_RAT
Sequence: MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQSIKKFSKVYGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGLGVIFSNGMQWKEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICSIIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNTFPAIIDYFPGSHNQVLKNFFYIKNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTETTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYIDLVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSAGKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLPPFYEACFIPVQRADSLSSHL
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and fatty acids.  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Metabolizes testosterone to 2alpha- and 16alpha-hydroxytestosterone (PubMed:2434473).  Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFAs) (PubMed:10491410, PubMed:15766564).  Converts arachidonic acid (ARA, C20:4(n-6)) primarily to epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, with both R,S and S,R stereochemistry (PubMed:10491410).  Preferentially produces 11R,12S-EET enantiomer.  To a lesser extent, catalyzes the hydroxylation of arachidonic acid producing hydroxyeicosatetraenoates (HETEs) (PubMed:10491410).  Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18-EETeTr, preferentially producing 17R,18S-EETeTr enantiomer (PubMed:15766564).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:2434473, PubMed:15766564).
What are the official names of this protein?
Cytochrome P450 2C11, CYPIIC11, Cytochrome P-450(M-1), Cytochrome P450-UT-2, Cytochrome P450-UT-A, Cytochrome P450H.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: C71DI_MENGR
Sequence: MELDLLSAIIILVATYIVSLLINQWRKSKSQQNLPPSPPKLPVIGHLHFLWGGLPQHVFRSIAQKYGPVAHVQLGEVYSVVLSSAEAAKQAMKVLDPNFADRFDGIGSRTMWYDKDDIIFSPYNDHWRQMRRICVTELLSPKNVRSFGYIRQEEIERLIRLLGSSGGAPVDVTEEVSKMSCVVVCRAAFGSVLKDQGSLAELVKESLALASGFELADLYPSSWLLNLLSLNKYRLQRMRRRLDHILDGFLEEHREKKSGEFGGEDIVDVLFRMQKGSDIKIPITSNCIKGFIFDTFSAGAETSSTTISWALSELMRNPAKMAKVQAEVREALKGKTVVDLSEVQELKYLRSVLKETLRLHPPFPLIPRQSREECEVNGYTIPAKTRIFINVWAIGRDPQYWEDPDTFRPERFDEVSRDFMGNDFEFIPFGAGRRICPGLHFGLANVEIPLAQLLYHFDWKLPQGMTDADLDMTETPGLSGPKKKNVCLVPTLYKSP
What is the function of this protein?
Hydroxylates (-)-(4S)-limonene to (-)-trans-carveol, a precursor of (-)-carvone.  Fluorinated substrate analogs are hydroxylated with the same regio- and stereochemistry.
What are the official names of this protein?
Cytochrome P450 71D18, (-)-(4S)-Limonene-6-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: E1078_IXORI
Sequence: MAFNTITFLQWAVFVAILFNMNLHSASAGSKGSSAQQSSHDSIKAEFCETNCTMKTGGKWTQCHGGCFCVHVGNETVGRCIKLDGDYDYPSSKHEE
What is the function of this protein?
Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL11 and CXCL13.
What are the official names of this protein?
Evasin P1078.
What are the subcellular locations of this protein?
Secreted.
Protein: YCIB_ECODH
Sequence: MKQFLDFLPLVVFFAFYKIYDIYAATAALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLGKELTLPQPVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PPAC_STRP7
Sequence: MSKILVFGHQNPDSDAIGSSVAFAYLAKEAYGLDTEAVALGTPNEETAFVLNYFGVEAPRVITSAKAEGAEQVILTDHNEFQQSVSDIAEVEVYGVVDHHRVANFETASPLYMRLEPVGSASSIVYRMFKEHGVAVPKEIAGLMLSGLISDTLLLKSPTTHPTDKIIAPELAELAGVNLEEYGLAMLKAGTNLASKSAEELIDIDAKTFELNGNNVRVAQVNTVDIAEVLERQAEIEAAMQAANESNGYSDFVLMITDIVNSNSEILALGANMDKVEAAFNFKLENNHAFLAGAVSRKKQVVPQLTESFNA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAL1_ECO24
Sequence: MSLKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSLDAPIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVIGDKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IQD29_ARATH
Sequence: MGKTPSPGKWIKSLLGKKSSKSSLEKGGEKLRSAKKEELVVKVKDNNVSKLPTEPPVVSSQEVAATQTVVVPDVVIAEKQLSGDIEGDESSNVNLESGNDSEEVKLEEAATKVQAALRAQQAREESQNLKGITRVQAVIRGHLVRRQAVATYSCIWGIVKVQALVRGKKARSSETVAQLQKTNTETETSETLQGSTYSWMENPTKLSMIDKLLVSSPTTLPLKIQYSPEDPNSAKVWLGRWTQLQVWAPGPLVVKNLVPKSQTKKRSFQAVEAEKGKLKRGVRKPTGVSTTANSSTSRSTADNEKPKRTVRKASTLGKELSKIENDKSKQSSRKSTSAIKEGSSVEVKDEKPRISHKKASLSNGIGKATRKSAEKKKEIADAVQKELPIEEVSVSLVDAPEDEKMNLIPVTISKESDLDKDEKSLVLDKPEQDELRTAERDDKAEEELKTAERDDSAEEKIQEPDAQISSENGNVASENTKPSDRRASLPAKIENHHQDDGLTQSGRKIPSYMAPTASAKARIRGQGSPRIAQEKPEKNGTTRRHSLPPAANGKLSTMSPRAHRLLIASAKGSMNSDRSFSSSKDIGDKSTKAEWKR
What is the function of this protein?
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity).  Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity).  May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
What are the official names of this protein?
Protein IQ-DOMAIN 29, AtIQD29.
What is the protein family that this protein belongs to?
Belongs to the IQD family.
What are the subcellular locations of this protein?
Nucleus. Nucleus envelope. Cytoplasm, cytoskeleton. Cell membrane. Note=Associates to cortical microtubules (MTs).
Protein: AGGF1_MOUSE
Sequence: MASEAPSPPSPSPPPPASPEPELAQLRRKVEKLERELRSCRRQVREVEKLLQHTERLYRNAESDNQELRTQVEELSKILHCGKNEDNPKSDVEVQTESQAPWAISDYYYQTCYNDDSLPSKETELCVQQSQCAQASALDPQDESHIDSGSYAGADATEGVSHRQEDAVTSDSQESVSALAEGPALEGSSLAESLRAAAEAAVSQTGFTYDESTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYQTSSTKPNRERRLKKRRKEPGFYTANEEKDLSSEDQKVCSVEYINCSEDEHSGNVKKKARTDTSHKSSPLQLTVAVSGDTVESPGDDNSASSKDERIGESESEPEEGEITDSQSEKSYDGDSSSGDRETSEESDDEDEERIWPPCIRVIVIRSPVLQMGSLFIITAVSPATIGREKDMEHTVRIPEVAVSKFHAEVYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSETCDGCEPGQVRAHLRLDRKDEPLVGPALSKEEKELERRKALKKIRVKYGLQNTDYEAEKALKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKRGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKLSSIDDVHLIQNKSKKHWDKARERFAETFTENKPRKETPGAVPWVTGTAE
What is the function of this protein?
Promotes angiogenesis and the proliferation of endothelial cells.  Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion (By similarity).
What are the official names of this protein?
Angiogenic factor with G patch and FHA domains 1, Angiogenic factor VG5Q, mVG5Q.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted (By similarity).
Protein: IF1_KORVE
Sequence: MSKEDAIEVMAVVIEPLPNAMFKVELENKHQVLAHVSGKMRKNFIRILPGDRVAVELSPYDLTRGRIVYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GHRA_SHIB3
Sequence: MDIIFYHPTFDTQWWIEALRKAIPQARVRAWKSGDNDSADYALVWHPPVEMLAGRDLKAVFALGAGVDSILSKLQAHPEMLNPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHWEDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESPLWQHPRVTITPHVAAITRPAEAVEYISRTIAQLEKGERVCGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_BORGP
Sequence: MKTLFFATTNENKINEVKNILDMPNLNLVVPKNFNIKETGTTFKENSLLKAKALFAILNKNQNVFGEDSGLCIEALNLEPGIYSKRYDTYKLCKKLSTNEKNQLILDLMKNEKNRKAYFICNISYISKDRQILNFEGIIKGEIALSLNDDKNYGFGYDSIFLTKNNKKLSDLTLEEKNKISHRGIAFSKFKKFLLKSLFNN
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: MMP7_HUMAN
Sequence: MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
What is the function of this protein?
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin.  Activates procollagenase.
What are the official names of this protein?
Matrilysin, Matrin, Matrix metalloproteinase-7, MMP-7, Pump-1 protease, Uterine metalloproteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: LEPA_SYNPW
Sequence: MTDAPVSRIRNFCIIAHIDHGKSTLADRLLQDTGTVANRDMQEQFLDNMDLERERGITIKLQAARMNYTAADGEEYVLNLIDTPGHVDFSYEVSRSLQACEGALLVVDASQGVEAQTLANVYLALENDLEIIPVLNKIDLPGADPDRIKEEVEAIIGLDCSKAIPCSAKTGLGVPEILQAVVDRVPAPKDAVEEPTKALIFDSYYDPYRGVIVYFRVMSGRINCKDKVLLMASKKTYELDEIGIMAPDQKKVDELHAGEVGYLAASIKAVADARVGDTITLLNAPADEPLPGYTEAKPMVFCGLFPTEADQYPDLREALNKLQLSDAALQFEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYDLDLIVTAPSVIYKVNMIDGTEVMVDNPATLPDPQKRESIEEPYVKMEIYAPNDYNGALMGLCQERRGEYLDMKYITTDRVTLIYELPLAEVVTDFFDQMKTRTQGYASMEYHLIGYRKNELVRLDVLINGERADPLTTIVHRDKAYNVGKALVEKLKELIPRQQFKIPLQASIGSRIIASTSISAIRKDVLAKCYGGDISRKKKLLKKQAKGKKRMKAMGKVDVPQEAFMAVLKLNDSP
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PRPKB_MOUSE
Sequence: MAGTSSEAEAEALAAARERSRLFLSGLELVQQGAEARVFRGRFQGRAAVVKHRFPKSYRHPELEARLGRRRTVQEARALLRCRRAGIAAPVVFFVDYASNCLYMEEIEDSVTVRDYIQSTMETEKDPQCLLDLARRMGQVLAGMHDQDLIHGDLTTSNMLLRRPLAQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETAFEAFLKSYGASSKKSSPVLKKLDEVRLRGRKRSMVG
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity).  Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity).
What are the official names of this protein?
EKC/KEOPS complex subunit Tp53rkb, Atypical serine/threonine protein kinase Tp53rk, EKC/KEOPS complex subunit Tp53rk, Nori-2, TP53-regulating kinase, p53-related protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. BUD32 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: END4_NATTJ
Sequence: MRLGFHMPLSGGVGKQLNRASELGMECIQIFSGNPTSWKPGKITPKSRDLFIKKQEELQIKPLVFHTPYLINLASPKNDIREKSIYLLNAALEKAKAYDAPYVVTHIGSHVGEGVEKGIDLVSYSLEKIMEDWPEGVELLLENTSGAGSTLGGSLTELKKIIDKFSGTQVLGCCFDTAHAWGAGYDISNVKEVETTLELVNEQLGLDLIKVCHANDTNVPLGSTKDRHQHIGEGNITDEGFGALLTHDSFTPKAVIMETPKNGTDCDQINLQRLKKVVGRHEEE
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: RS30_ORYLA
Sequence: KVHGSLARAGKVRGQTPNVDKHEEKEEEDGRAKRRIQYNRRFVNVVPTFGKKKGANANS
What are the official names of this protein?
40S ribosomal protein S30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS30 family.
Protein: PHS_SHEB8
Sequence: MTALSNMKCEACQADAPKVTDEELAELIRMIPDWGVQVRDGVMQLERVYKFKNFKLAMAFTNKLADLAEEEFHHPGIFTEWGKVTVTWWSHSIKGLHKNDFIMAAKTDQLLV
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: RNH_ACISJ
Sequence: MNQVVIYTDGACKGNPGPGGWGAVLRSGTLEKELFGGELGTTNNRMELMAVIQALGALKRPCQVALYLDSQYVRQGITEWIHGWKKKGWRTAAGQPVKNVELWQRLDELAHQAGHRIEWHWVRGHAGDPGNERADMLANKGVEQVLGR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_COXBN
Sequence: MADMSVKQLADLVRTTPERLLEQLKEAGVAITHVDQTISDEEKRKLLLHLKTSHSTETDKKRSKIVLKRKKLSVVKSGKKSVNVEIRSKRTYTKPVVEQKRETEPAPTQEVPLTSDTTNLNEKAEVNVATLEKAVEAEVKEEAKKTPSEKKETPKKGPRKETRRSRKPDKEDKWEREELHMTKLVEERRRRHKPAHMPDSDNASAKLEQGFARPTAPVVREVALPESITVADLAQKMSVKAAEVIKAMMKLGAMVTINQRIDQETAAIVVEEMGHKPKLIKEDVLEENLVATLGEQTGEAVPRAPVVTIMGHVDHGKTSLLDYIRRTKVTSTEAGGITQHIGAYHVETELGMITFLDTPGHEAFTAMRARGAKCTDIVVLVVAADDGIMPQTVEAIQHARAAKVPVVVAVNKIDKPEADPERIKTELSTHDVLPEEWGGDTMFQPISAKTGEGIDALLERILLQAEVLELKAVDNGPARGMVVESRLDRGRGPVATVLVTSGELHLGDILLVGREYGRVRAMIGDDGRPCESAGPSMPVEVLGLSGTPVAGEEAIVVPDERKAREIARFRQGKYREVRLAKKQTAHLERIFDRMGEGKQNTLNIVLKADVQGSLEALTEALNKLSTDEVKVNIIASGVGGITESDVNLAIASDAVVIGFNVRADAPTRVLVEREGVDLRYYSIIYDLIDEVKKALSGLLAPEFEEKIVGLAEVRDVFRSSKIGAIAGCMVVEGVVRRHLPIRVLRDNVVIYEGLLESLRRYKEDVAEVRQGTECGIGVKNYNDVKVGDQIEVYEKTQVHRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAD9A_MOUSE
Sequence: MKCLITGGNVKVLGKAVHSLSRIGDELYLEPLKDGLSLRTVNSSRSAYACFLFAPLFFQQYQAASPGQDLLRCKILMKAFLSVFRSLAIVEKSVEKCCISLSGSHSHLVVQLHCKYGVKKTHNLSFQDCESLQAVFDPASCPHLLRTPARVLAEAVLSFPLALTEVTLGIGRGRRVILRSYQEEEADSTSKAMVTETSIGDEDFQQLHAPEGIAVTFCLKEFRGLLSFAESANLPLTIHFDVPGRPVIFTIEDSLLDAHFVLATLLEQDSCSQGPCSPKPHQPVPQKQAHSTPHLDDFTSDDIDCYMIAMETTGGNEGSGAQPSTSLPPVSLASHDLAPTSEEEAEPSTVPGTPPPKKFRSLFFGSILAPVHSPQGPNPVLAEDSDGEG
What is the function of this protein?
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.  The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.  Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER).  The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates.  The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.  RAD9A possesses 3'->5' double stranded DNA exonuclease activity (By similarity).
What are the official names of this protein?
Cell cycle checkpoint control protein RAD9A, mRAD9, DNA repair exonuclease rad9 homolog A, Rad9-like protein.
What is the protein family that this protein belongs to?
Belongs to the rad9 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CKCS_CAMSB
Sequence: MELATREKVNEVLFMNRGEGESSYAQNSSFTQQVASMAQPALENAVETLFSKDFHLQALNAADLGCAAGPNTFAVISTIKRMMEKKCRELNCQTLELQVYLNDLFGNDFNTLFKGLSSEVIGNKCEEVPCYVMGVPGSFHGRLFPRNSLHLVYSSYSVHWLTQAPKGLTSREGLALNKGKIYISKTSPPVVREAYLSQFHEDFTMFLNYRSQEMVPNGCMVLILRGRQCFDPSDMQSCFTWELLALAIAELVSQGLIDEDKLDTFNIPSYFASLEEVKDIVERDGSFTIDHIEGFDLDSVEMQENDKWVRGEKFTKVVRAFSEPIISSQFGHEIMDKLYDKFTHIVVSDLEAKLPKTTSIILVLSKIVG
What is the function of this protein?
Involved in the biosynthesis of caffeine in cv.  Puer (PubMed:32193380).  Involved in the biosynthesis of theacrine in cv.  Kucha, a caffeine-like xanthine alkaloid with diverse beneficial biological activities including anti-depressive, sedative, and hypnotic activities, improving learning and memory, increasing exercise activity, and preventing nonalcoholic fatty liver disease (PubMed:32193380).  Catalyzes the conversion of 7-methylxanthine (7mX) to theobromine and of theobromine to caffeine (PubMed:32193380).  Has 3-N- and 1-N-methylation activity (PubMed:32193380).
What are the official names of this protein?
3,7-dimethylxanthine N-methyltransferase TCS1, Caffeine synthase, CkCS.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
Protein: MTNW_BACC3
Sequence: MSGIIATYLIHDDSHNLEKKAEQIALGLTIGSWTHLPHLLQEQLKQHKGNVIHVEELAEHEHTNSYLRKKVKRGIIKIEYPLLNFSPDLPAILTTTFGKLSLDGEVKLIDLTFSDELKKHFPGPKFGIDGIRNLLQVHDRPLLMSIFKGMIGRNIGYLKTQLRDQAIGGVDIVKDDEILFENALTPLTKRIVSGKEVLQSVYETYGHKTLYAVNVTGRTFDLKENAKRAVQAGADILLFNVFAYGLDVLQSLAEDDEIPVPIMAHPAVSGAYSASKLYGISSPLLLGKLLRYAGADFSLFPSPYGSVALEKEEALAISKYLTEDDVFFKKSFSVPSAGIHPGFVPFIIRDFGKDVVINAGGGIHGHPNGAQGGGKAFRTAIDATLQNKPLHEVDDINLHSALQIWGNPSHEVKL
What is the function of this protein?
Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P).
What are the official names of this protein?
2,3-diketo-5-methylthiopentyl-1-phosphate enolase, DK-MTP-1-P enolase, RuBisCO-like protein, RLP.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type IV subfamily.
Protein: RGA6_SCHPO
Sequence: MTLNPSTLNNGTLGDLKEHKDVVLSSNAQTDEKRFEEPSLEVGGSLAKVENGLSTSISSSASNLEGQQAPFFTKQNSCLSRFRELAQTYNIHEINLEEYVSQIKEVKQSLYSDDSVFNESKSSSPPDAHTDKYFTPCGSPTKLIHSTLLEERDTPSSLEHVSFYLQESAVSEVRFDKPSNNGPLGRSSLNLSSLSHELQTSQDSPSLSATNQLSSSDTLEPLQYPPSSFGSQRQFNASQDSPKRSPSKGSWSSILRRPSLTYSPKRQSTGLHRRSLTNYFKFPHRNAHQHNAIAHNPSVFGKPIGDLTSDPTNLCKFTFPTPECAPPSLLLPHIFAQCVHFLSLNALHVPGIFRISGSGPVIKAITEYFYSPPHFWLDETSEIFKRIGFPSYIDIAAVLKRYIMLLPGGLFTHKDILNLLVPLYVDSSRVKVPIDIRNEMAALCFSQIDSYVRFSILCSLLALLHQIATRTQELENGMENTKDSTLMKPEALGIIFGPLLLGNSSTDLSKSCPSGNVNDLMRFETEKARVEAKIVEGLIIHWPEVLLKINSLDIPNCFSDVGLTDQVAIFTPAVPKEDSPEQIPENVNASEESYPNVKHISKLPLINDSSDNESGNQENDDAVANESTKVVVDNQQPQPKISTVSDTAVPSMSFANNISSRSVISAATDSKPSTRTSPPFVNNTKPIVAKSPVTVTASSETNKKSQKINKKASPRVSLWTKLFGKFRSNKKKS
What are the official names of this protein?
Probable Rho-GTPase-activating protein 6.
Protein: ITPA_RAT
Sequence: MAASLVGKKIVFVTGNAKKLEEVIQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLYQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGKTPGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKAEKNTISHRFRALFKLQEYFGVTDGAGDH
What is the function of this protein?
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm.