PharMolix/UniProtQA huggingface dataset:
Protein: OFUT2_MOUSE
Sequence: MAALSVVCLLLAAASWRPVSASGEEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRRDVYIRVASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAESGGPFIDQVYVLQGYAEGWKEGTWEEKVDARPCIDPLLYSQDKHEYYRGWFWGYEETRGLNVSCLSVQGSASIVAPVLLKNTSARSVMLDRAENLLHDHYGGREYWDTRRSMVFAKHLRAVGDEFRSQHLNSTDAADKMAPEEDWTKMKVKLGSALGGPYLGVHLRRKDFIWGHREDVPSLEGAVKKIRSLMKTHQLDKVFVATDAIRKEQEELRKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKIAY
What is the function of this protein?
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:20637190).  O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (PubMed:20637190).  Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (By similarity).  The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (PubMed:20637190).
What are the official names of this protein?
GDP-fucose protein O-fucosyltransferase 2, Peptide-O-fucosyltransferase 2, O-FucT-2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 68 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Note=Mainly located in the endoplasmic reticulum.
Protein: RL16_KOCRD
Sequence: MLIPRRVKFRKQHHPRRRGQAKGGTQVTFGEWGIQAMSPAYVTNRQIEAARIAMTRHIKRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWIANVKPGRVMFEISGVSEDVAREALRLAIHKLPMKARIVRREGGE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: GLSA_SERP5
Sequence: MVTTLDNALLEEILQQVRPLIGQGKVADYIPALAEVASDRLAIAVCTVDGEIFQAGNATERFSIQSISKVLSLTLALTRYQEHEIWQRVGKEPSGLPFNSLLQLEMEQGKPRNPFINPGALVVCDMLQTRLSAPKQRMLEVVRQLAGEEDLAYDSRVARSEFEHSDRNAAIAYLMKSFGNFENDVLTVLQTYFHYCALRMSCLELARSFVYLANHGRDLSGREVISPLQARQINALMMTSGMYDGAGEFAYRVGMPGKSGVGGGIVAIVPDELSIAVWSPELDASGNSLAGTAALELLSQRISRSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: RLMN_SALAR
Sequence: MSEQIVTPESSTPVVSNNEAKINLLDLNRQQMREFFKNLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLTNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDAIRDEIVPINKKYNIETFLGAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKETPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2672_SHEB2
Sequence: MAFDKKLLDIVACPVCKGKLEYDKTTQQLICKADKLAYPITEGIPVLLENRAVPLTESV
What are the official names of this protein?
UPF0434 protein Sbal223_2672.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: PQQD_STUS1
Sequence: MSEIQLTQVPSFRRGFRFQWEPAQNCHVLLYPEGMIKLNESAAAVLTEVDGTRTVGAIVADLQARYPEAEGIQEDIVAFLEVAVERFWIELR
What is the function of this protein?
Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
What are the official names of this protein?
PqqA binding protein, Coenzyme PQQ synthesis protein D, Pyrroloquinoline quinone biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the PqqD family.
Protein: AMPD3_HUMAN
Sequence: MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQKELAEQKSVETAKRKKSFKMIRSQSLSLQMPPQQDWKGPPAASPAMSPTTPVVTGATSLPTPAPYAMPEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYARLAYHRFPRITSQYLGHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN
What is the function of this protein?
AMP deaminase plays a critical role in energy metabolism.
What are the official names of this protein?
AMP deaminase 3, AMP deaminase isoform E, Erythrocyte AMP deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Protein: MTFP1_DANRE
Sequence: MEPSADTHSKPVDIYRDTWVRFLGYANEVGEAFRALVPVGAVWASYGVATTYVTADAIDKGRKAAAAHGERPGKAVCVCVAVVDTFVWQALASVAVPGFTINRVCAASHFLLSRTTRWPLPVRKWTTTAIGLSTIPFIITPIDRSVDLLLDSSLRKLYSEGEKED
What is the function of this protein?
Involved in the mitochondrial division probably by regulating membrane fission.  Loss-of-function leads to apoptosis (By similarity).
What are the official names of this protein?
Mitochondrial fission process protein 1, Mitochondrial 18 kDa protein, MTP18.
What is the protein family that this protein belongs to?
Belongs to the MTFP1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SSRP_ALKCK
Sequence: MGETTEGKVVAQNKKARHDYFIEETFEAGIVLTGTEIKSIRAGKMNLKDSFARIKNGEAFLYNAHISEYEQGNRYNHEPTRPRKLLLHKKQINTLIGQTQQKGYSIVPLKVYIKNGFAKVLIGLAKGKKNYDKRETLRRKDAKREVERAIKERMRG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: WHI4_YEAST
Sequence: MSLVHNQTNLNESKFLIERAFSSSSETVPLSKEATYPMPTAYSFSAVRSNSETNIKRENPQGFAKEPIMTSMLHNLTMSTGKGNGNDVNSLAPHDVDVGPYCLLLRNLPKDITLRECYCIFSLATGVSSIELKRDDREPFNDNEKVVVVKFGSLSLVTHYANILNSKSEIFGPSFPFRSHIDVVNEQTQLPVSFQEHVSSGTTNSSPKNYQLSSSAQNEIQNQSFNTISYGKTSSSPLGPSAAKPRPSLLSERSLRFSFNDPFGLETISQRKESVPFLRNSISQHDLSNVTTTPVPAGMPPQKDAGKSLLLLEKDEINESIWNGDELVNDVGNSSFGASLQEPPMSSTPVMEWNASSTANIPLFQLSSQENHQSNLLPPSHHSISQDVPHIQSQPNLNNSGVIHSATSLPHYHLLNQINASTKTQSIQQSVSNVPSNLDLNLQTENGHPQSSAPNGSSIFNNQKVNQGFLVSEQDTSTISRQKECSSTASASAFSKNNETNVAGSTTISQADLSLLAKVPPPANPADQNPPCNTLYVGNLPPDATEQELRQLFSNQQGFRRLSFRNKMNSHGHGNGHGHGPICFVEFEDVSFATRALAELYGSQLPHPRPSLNNKGGIRLSFSKNPLGVRGSNSRSKSGYSFNGSYGKS
What is the function of this protein?
Has a partially redundant function to WHI3, a dosage-dependent modulator of cell size.
What are the official names of this protein?
Protein WHI4.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFP_PORGN
Sequence: MAKSALHLARMSYQPKMPASLQGAVKIIEGKATEAVSDKEEIAAIFPRTYGLPLISFAPGGERTEYPPTNVGVILSGGQAPGGHNVIAGLFDEMKLLNPDSRLFGFLMGPDGLIEHKYRELTAEVIDEYRNTGGFDMIGSGRTKLDKPEQFEAGLEILRELDIKALVIIGGDDSNTNACILAEYYASIDAGIQVIGCPKTIDGDLKNKQIETSFGFDTAAKVYSELIGNIQRDCNSARKYWHFIKLMGRSASHITLECALQTHPNICIVSEEVEANNYYLDDVVTYIAETVVRRSEAGMNFGTVLIPEGLIEFLPAMKRLIKELNEFLSQNDAEFKLIKRSAQRQYIKNKLSPENSRLYDSLPVDVARQLIADRDPHGNVQVSLIATEKLLADMTAQKLAEWAEEGRFQGRFSTLTHFFGYEGRCAMPSNFDANYCYCLGRAASILIAAGKTGYMAAIKNTADPVSEWEAGGVPMTMMMNMERRSGKMKPVIRKALVDMDGEPYRALREMRREWALSTEYVYPGPIQFFGPEHVCDSPTMTLRLEKNDR
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis.  Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.  Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
What are the official names of this protein?
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase, 6-phosphofructokinase, pyrophosphate dependent, PPi-dependent phosphofructokinase, PPi-PFK, Pyrophosphate-dependent 6-phosphofructose-1-kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_SHESA
Sequence: MRLTDIEIEQALDNGSIVIEPRPSNDAISGVSVDVRLGGQFRVFKDHTAPFIDLSGPSTEVQAALDRVMSEIIEIPDGEAFFLHPGELALAVTYESVTLPADIVGWLDGRSSLARLGLMVHVTAHRIDPGWQGKIVLEFYNSGKLPLALRPRMTIGALNFERLSGPVARPYNKRKNAKYKDQQDAVASRISQD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: GLK_ECOL6
Sequence: MTKYALVGDVGGTNARLALCDIASGEISQAKTYSGLDYPSLEAVIRVYLEEHKVEVKDGCIAIACPITGDWVAMTNHTWAFSIAEMKKNLGFSHLEIINDFTAVSMAIPMLKKEHLIQFGGAEPVEGKPIAVYGAGTGLGVAHLVHVDKRWVSLPGEGGHVDFAPNSEEEGIILEILRAEIGHVSAERVLSGPGLVNLYRAIVKADNRLPENLKPKDITERALADSCTDCRRALSLFCVIMGRFGGNLALNLGTFGGVFIAGGIVPRFLEFFKASGFRAAFEDKGRFKEYVHDIPVYLIVHDNPGLLGSGAHLRQTLGHIL
What is the function of this protein?
Not highly important in E. coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate.
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_ENDTX
Sequence: MNYLIETIGCQMNVCDSDMLVSIFSAYGASKANNLSEADVVILNTCSVRSQAEQKAFSYLGRVKEFKQKNPCIKIVVIGCMAERLGPNIKKRFSSVDLIIGAKDIGNAALKIMNLFRTDYSAKKVNSEIKSKIVRYITIMRGCDNYCSYCAVPFVRGREVSINCETIVNECSSMVKNGAREIILLGQNVNSYQYEDVNFASLIKKTAAIENLERIRFMTNHPKDLSDDLIKIMATEPKVCPHIHIPMQSASDKILKAMNRKYSYEHYLGLIKKLRTAVPDVSVTTDIIVGFPGETDEDFEDTLKAVKTIRFGGLYVFRYSPRPDTKAAEMIDDVPFEEKKRRHAVVLKESNKISIEIVSEMLGSTQQVLAEEIKNGIIKARTKNGRKVFAEGRKEYIGKHINVNIKEAKINSLFGDIV
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTU1_CAEBR
Sequence: MEKRRGPPPCQSEEGCSNSAKIRKAKNGAQLCGPCFSKSFEDDVHETIINNNLFKRGERVAIGASGGKDSTVLAFVMKTLNDRHDYGLDLQLLSIDEGIKGYRDDSLLAVEKNRVEYGLPLTILSYNDLYGWTMDDIVAKIGKKNNCTFCGVFRRQALDRGAFKIGATKLVTGHNADDMAETVLMNVLRGDIARLERCTNIVTGEEGDLPRAKPLKYCFERDIVMYARSNQLEYFYTECIYAPNAYRGYARKYVRDLEKVHPRAILDLIRSGEKVSVKKEVEMPTLKTCERCGYMTSQKMCKACLLIEGLNTGNTDLGVRKSKKTKKVIVETEGGKKEDGGCGSGGGGCGCAGAADETENEETRKRLKDLQF
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1, Thiolation of uridine in tRNA protein 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_CYLCV
Sequence: MSNNRRNVRTPTKFDKNTKTIQIFGKTSIVLKNMSIQERIDEVTQLLKQLKMIRDEETNTQKALIMEHEEVVYNYESSEEGFPVEPKTEEKDIPSTSGQKRTYEFMKDDFWNSGEFDKYAEKRGFIKKDGGGYSKIPKEYKPIHQDENSSILNLDCIDNAPALFVSWTSKHGLELQLNKHFENFSDNEIWNYTQYYTRGSVQKFLSEQDYQTDVAPNLALVQGGPYAKFKYIVQTIYGEFIGKDIRDHSQDLINQEAEKARFHLANMIICDLCYFDNYTCEYRKYFYMLTPDERSTYIELFLQKLPAPFGRKMMEGFRKETAENKIANTLGGAIDIVRRTIDEECIQRSYRRTIGGAVKICCKGNPEIPQRYGCYDITKRKKTSKKKWKKRSYKPDLWKKKKRFFKRRDFSKKKKENPGKKKFCPTGKKSCKCWICHEEGHYANECPKKTKEKHKDKVKLLMEAEEEGFEPLESEASDIEEIFEIVEEDSESSSEEDEEQR
What is the function of this protein?
Self assembles to form an icosahedral capsid, about 50 nm in diameter, nm, composed of 420 subunits of the viral capsid protein.  The capsid encapsulates the genomic dsDNA.  Following virus entry into host cell, provides nuclear import of the viral genome.  Virus particles do not enter the nucleus, but dock at the nuclear membrane through the interaction with host importins (By similarity).
What are the official names of this protein?
Capsid protein, CP, coat protein.
What is the protein family that this protein belongs to?
Belongs to the caulimoviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: THIM_ALKMQ
Sequence: MLELEESSKIIEKIKYNKPLIHHITNYVSVNDCANIVLALGGSPIMADDPKEVVEVVSKASALVINIGTLNDKRVQSMLLAGRKANELGIPVILDPVGVGASTFRKDTVNQLLKNIDFTVIRGNASEMQVLMNMNYSVAGVDSMDFGGNTPKMIRTLAQKYKTTVAITGATDSICDGTTLISVSNGHSLLSQVTGTGCMTTSLIATCLAVTDQALLAALAGVLIMDLAGEGAYASLKAHESIGTFKVRIFDHIHQLTEQTILEGGSLDVSYR
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: PUF6_SCHPO
Sequence: MAIGKRKESTEVKKKDGSMNKRVKVAKLPKKVDSFSPKKKKNTTSSGSSESDSMSQNDKKKDSSLNESEDEDFAGFGESASENDELESAESEAENDEESSSQKSNSKESHAQRKKLQKERKAMKPFADTSLKAKSLWDKLRQKTSIKAEERKTIIAELFDLIRTNVKQLVFKHDMSRVVQTCVKFGSKQQRETICAELAGSYVDLCKSPYGKYLAIKIFKYGTPKMKEVILGEMYGNVVKMIRHREAAYVVEDAFREFTNLQQQRALICEFYGPEFQVFKDRTQDIHIDKLLIDHPEKRPSIMQNLWKTIEGSIAKGSIGFTMVHRAMLEFINHADSNEAKELLNLTKELIYEFVHTRDGSQVAMKLFALANAKDRKVMLKSLRPYLIETAKDSYGHLVVVAALDCTDDTIMTGKLLQAEFEGELLKLSADKFARRILLYVLVGWEDARYFSKENRELLRSLDSLKAKTSKKDPIVRRNELKATIGPLLISLISKAAGDMIAESLASQVLVDALLYAPCEKEEAVDATLKAFDGNPEQDNHLIHQIHCSRALKTLVQNGHWSGAEKQVVKAEDDLKVASKLIVIIKKYLVEWASGDGAFVVVAVLEALSDSEKQEFLKILRKHKNQLNKSEFRGTKKLLEML
What is the function of this protein?
RNA-binding protein involved in post-transcriptional regulation.
What are the official names of this protein?
Pumilio homology domain family member 6.
What is the protein family that this protein belongs to?
Belongs to the PUF6 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ATPF_PROM5
Sequence: MNLPLLATEGFGLNLNLFETNVLNWAVVVFGLYKFLPSFLGKMLQKRREGILLELKDAEDRLLKATQALEKAKTDLSLAEEKASQIKADSLKRSESIRMESEKKAIEEMARIKQSAISDESSEASRAISQLRKEAVELAIKKALDSLPNRLDQTTQENLVTQSINNIEMN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PSTB_PASMU
Sequence: MNTQIIQLEDTKLEVNNLNFHYGDFHALKNINMRIAKHKVTAFIGPSGCGKSTLLRSFNRIFELYPNQYATGEIKLDGENLLTSPMDISLIRAKVGMVFQKPTPFPMSIYDNVAFGIRLFEKLSKADLNDRVEWALSKAALWNEVKDKLNQSGDSLSGGQQQRLCIARGIAIKPEVLLLDEPCSALDPISTAKIEELISELKHDYTVVMVTHNMQQAARCSDYTAFMYLGELIEFDETAKIFDKPRLQRTEDYIKGRMG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YTH1_CANGA
Sequence: MGSVVHPDTEKYPFKFEPFLRQEYSFALDPDRPVCEDFNYKIGPSSCPNGVFCPKKHVLGIFQNKIVCKHWLRGLCKKNDNCEYLHEYNLRKMPECVFYAKNGFCTQSPECQYLHIDPLSKVPPCEDYEMGFCPKGSACEKRHIKKVLCQRYINGFCPLGRRECDMEHPFFYIPDLSSPLRIKKDEEINTRKRDEENERRLNAIINGEI
What is the function of this protein?
Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
What are the official names of this protein?
mRNA 3'-end-processing protein YTH1.
What is the protein family that this protein belongs to?
Belongs to the CPSF4/YTH1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPF_ECOK1
Sequence: MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPTFKGADSRELLREAWRRIQAKGYALGNVDVTIIAQAPRMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: DNAJ_SYNFM
Sequence: MGKRDYYEILGVTRQASEEEIKKAYRKLALKYHPDRNPGDKDSEELFKEAAEAYEVLHDAQKKRIYDTYGHEGLRGTGFSGFRGFEDIFSSFGDVFQEFFNFGFGAGGQSRTAARPGDDLLYDLSLTFEEAVFGTEKEIRLQTLTTCEECNGSGAEPGTRETVCPVCQGSGQVVQSQGFFRISATCTRCQGMGKVLVSPCKTCNGQGRTRQSKTVQVRVPAGVDTGTRLRLRGEGESGYRGGVAGDLYVRLHVNPHEFFERDGDNLYCKVSVSFAQAILGDQIEIPTLDGGRELKIQPGTQPGAVIRFSGEGVPRLRGYGRGDLFIEVEVKIPTRITPRQEEIVTEFMQIEKEKSGEKVRKWPWSKRKDREKKSMAESTREART
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACDH4_PARXL
Sequence: MTKKIKCALIGPGNIGTDLLAKLQRSPVLEPIWMVGIDPESDGLKRAREMGIKTTADGVDGLIPHMQADGVQIVFDATSAYVHADNSRKVNALGALMIDLTPAAIGPFCVPTVNLKEHVGKGEMNVNMVTCGGQATIPMVAAVSRVQPVAYGEIVATVSSKSAGPGTRKNIDEFTRTTAGAVEKVGGAKKGKAIIILNPAEPPLIMRDTVHCLLESEPDQAKITESIHAMIKEVQKYVPGYKLVNGPVFDGLRVSVYLEVEGLGDYLPKYAGNLDIMTAAAARTAEMFAEEILAGQLTLQPVHA
What is the function of this protein?
Catalyzes the conversion of acetaldehyde or propanal to acetyl-CoA or propanoyl-CoA, respectively, using NAD(+) and coenzyme A.  Displays broad specificity since it can utilize aliphatic aldehydes from two to five carbons in length as substrates; the aldehyde substrates can be directly channeled from the aldolase BphI to the dehydrogenase BphJ.  Is the final enzyme in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs).  Is also able to utilize NADP(+) instead of NAD(+).  Is not active with succinic semialdehyde or picolinaldehyde as substrates.  Can also catalyze the reverse reaction, i. e.  the reductive deacylation of acetyl-CoA to acetaldehyde, which is then channeled to the BphI active site.  The BphI-BphJ enzyme complex exhibits unique bidirectionality in substrate channeling and allosteric activation.
What are the official names of this protein?
Acetaldehyde dehydrogenase 4, Acetaldehyde dehydrogenase [acetylating] 4, Propanal dehydrogenase (CoA-propanoylating).
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: AAKG_YEAST
Sequence: MKPTQDSQEKVSIEQQLAVESIRKFLNSKTSYDVLPVSYRLIVLDTSLLVKKSLNVLLQNSIVSAPLWDSKTSRFAGLLTTTDFINVIQYYFSNPDKFELVDKLQLDGLKDIERALGVDQLDTASIHPSRPLFEACLKMLESRSGRIPLIDQDEETHREIVVSVLTQYRILKFVALNCRETHFLKIPIGDLNIITQDNMKSCQMTTPVIDVIQMLTQGRVSSVPIIDENGYLINVYEAYDVLGLIKGGIYNDLSLSVGEALMRRSDDFEGVYTCTKNDKLSTIMDNIRKARVHRFFVVDDVGRLVGVLTLSDILKYILLGSN
What is the function of this protein?
Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.  In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.  AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.  Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (SNF1) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
What are the official names of this protein?
5'-AMP-activated protein kinase subunit gamma, AMPK gamma, AMPK subunit gamma, Regulatory protein CAT3, Sucrose non-fermenting protein 4.
What is the protein family that this protein belongs to?
Belongs to the 5'-AMP-activated protein kinase gamma subunit family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.