PharMolix/UniProtQA huggingface dataset:
Protein: SLYA_ECO5E
Sequence: MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLITLIAKLEHNIIELQAKG
What is the function of this protein?
Transcription regulator that can specifically activate or repress expression of target genes.
What are the official names of this protein?
Transcriptional regulator SlyA.
What is the protein family that this protein belongs to?
Belongs to the SlyA family.
Protein: ATPBM_NICPL
Sequence: MASRRLLASLLRQSAQRGGGLISRSLGNSIPKSASRASSRASPKGFLLNRAVQYATSAAAPASQPSTPPKSGSEPSGKITDEFTGAGSIGKVCQVIGAVVDVRFDEGLPPILTALEVLDNQIRLVLEVAQHLGENMVRTIAMDGTEGLVRGQRVLNTGSPITVPVGRATLGRIINVIGEAIDERGPITTDHFLPIHREAPAFVEQATEQQILVTGIKVVDLLAPYQRGGKIGLFGGAGVGKTVLIMELINNVAKAHGGFSVFAGVGERTREGNDLYREMIESGVIKLGEKQSESKCALVYGQMNEPPGARARVGLTGLTVAEHFRDAEGQDVLLFIDNIFRFTQANSEVSALLGRIPSAVGYQPTLATDLGGLQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRQISELGIYPAVDPLDSTSRMLSPHILGEDHYNTARGVQKVLQNYKNLQDIIAILGMDELSEDDKMTVARARKIQRFLSQPFHVAEVFTGAPGKYVDLKESINSFQGVLDGKYDDLSEQSFYMVGGIDEVIAKAEKIAKESAA
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Protein: IF4A_BOTFB
Sequence: MASADKGLEEIQEGQIESNYDETVDSFDTMNLKPELLRGVYAYGFERPSAIQQRAIMPVIKGHDVIAQAQSGTGKTATFSISVLQKLDPNVKQCQALILAPTRELAQQIQKVVVAIGDFMNVECHACIGGTSVRDDMKALQDGPQVVVGTPGRVHDMIQRRFLKTDSMKMFVLDEADEMLSRGFTEQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTKFMRDPVRILVKKAELTLEGIKQFYIAVEKEDWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMDQGQRDLIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYSTQIEEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase eIF4A, Eukaryotic initiation factor 4A, eIF-4A, Translation initiation factor 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADRM1_RAT
Sequence: MTTSGALFPSLVPGSRGSSTKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGTVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNECLNNPPMPGTLGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPASSSSSSSRSQSAAVTPSSTTSSARATPAPSAPAAASATSPSPAPSSGNGTSTAASPTQPIQLSDLQSILATMNVPAGPGGSQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTAEEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKSDPKEGDTKDKKDEEEDMSLD
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.  Within the complex, functions as a proteasomal ubiquitin receptor.  Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation.  UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
What are the official names of this protein?
Proteasomal ubiquitin receptor ADRM1, 110 kDa cell membrane glycoprotein, Gp110, Adhesion-regulating molecule 1, ARM-1, Rpn13 homolog.
What is the protein family that this protein belongs to?
Belongs to the ADRM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ATG7_SCLS1
Sequence: MALKFAPFASEIELPFYTALSQLKIDHDKLDDSARPVLGLYEPRATQSPDQSSRMRVLGNALSSTEVPLGHIRAEGIIKNVNTIEDFKNTDKQAMLQTSAKQIWDAINDGTIYSIPSLLSSFTILSFANLKKYTFTYWFAFPALHSEPAWKKVEQPPKFSAEETTALTEELAKRVYPSLEQPQDPENESNSDLPFKWVIGSLREFEDGFFNGVDAKDQYVSFVDPSTYLENPGWMLRNLLVLIRRRYKLDKVQILCYRDNHAKRHVPQSLILVLESIYDPEYQSTGPDETPKVTGWERNSLGKLTAKVTNLAQYMDPAQLADQAVDLNLKLMKWRIAPELDLDAIKNTKCLLLGAGTLGTYVSRLLMGWGVRKITFIDNASVSFSNPVRQPLFDFKDCIDGGAKKAYRAAEALQEIYPGVDSTGHVMSVPMLGHPITDEAATKMDFELLQKLVEDHDAIFLLMDTRESRWLPTVMGKAAGKIVMNAALGFDTYVVMRHGVTPEDGGPAALGCYFCNDVVAPSDSVKDQTLDQQCTVTRPGVAPEASSKLVELLASVLQHPLRGAAPAPKLSANQQSGQMEFDRDPPNHPLGLVPHQIRGFLSAYKTMLISGPSYDCCSACSPKIVNAYKEDGWEFIKRALTEKDYITELSGLAEVQRKAEEAANDVEWDSEEEGVEDEEAELL
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme atg7, ATG12-activating enzyme E1 atg7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: RNPS1_DANRE
Sequence: MAPSPTKRRERSEDKPRERGKEKAPAKEGAEKERGRDKIRKRRSNSTGSSSSRSSSSSSSSSGSSSGSSSGSSSSSGSSRSGSSSSSRSSSSSGSSGSPSPSRRRHDNRRRSRSKSKSQKRTDEKERKRRSPSPKPTKLYLGRLTRNVTKDHIQEIFATYGKIKMIDMPSDRLHPNVSKGYAYVEYESPEDAQKALKHMDGGQIDGQEITATAILAQRIRPAPRRLSPPRRMPPPPPMWRRTPPRMRRRSRSPRRRSPVRRRSRSRSPGRRRHRSRSSSNSSR
What is the function of this protein?
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs.  The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome.  May participate in mRNA 3'-end cleavage.  Also mediates increase of mRNA abundance and translational efficiency (By similarity).
What are the official names of this protein?
RNA-binding protein with serine-rich domain 1.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein.
Protein: RRP4_THEKO
Sequence: MKKIFVKPRELVVPGTLLAQGPFKNGRGTFREGNAIYSTVIGLVEIRGNVIRVIPLEGPYIPEVGDNVLGKIVDVKFSSWTVDIGAPYQASLRVQDAVEERIDLLKTDLRKIFDIGDIIYAKVKAFNEVNQIDLTTKGMPFKGGPLRGGQLVTITPSKVPRLIGKGGSMINMIKTLTGTRIIVGQNGWVWVSGKNDELERLAIEAILKVDRESHTQGLTDRVKEFLLSRLRELKEQGVIEEIPEVNGEEGGEDDGQA
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Increases the RNA binding and the efficiency of RNA degradation.  Confers strong poly(A) specificity to the exosome.
What are the official names of this protein?
Exosome complex component Rrp4.
What is the protein family that this protein belongs to?
Belongs to the RRP4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBA_SECCE
Sequence: MTAILERRESTSLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEVPSING
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ZDH11_DANRE
Sequence: MTNLNCFGRHRRRTAPHNATGSRSELVAPPIHSRINGWSSPLHSFQFIALLIFSFMAIVAFGIYVPLLPAPWSYAAYALIGSAFVLHLFSHVTAVTIDPADVNVRRRKDYSSPMPTFDNSKHPHVIDNLHCTLCEVDVSPKAKHCSTCNKCIADFDHHCKWLNNCVGGRNYWFFFTAVSSAVIGVILLIPLVLFVFIEHYVNPAVLRTAPQFQTVKGNGTWLVFLPVAPVETSSISLLVVSFITALLSLAALLLLCHLLCFHIYLLSQGISTYEYIVRKRQSPNPKEKQQVPPALPSNGATAQSLELQEPPLNCDAPLSSRSCTFKLEDRGPMPEPICAEMEEASGEHHLSYSSESATQKIAGESVMSLPVVWSLSETERPQASQVEVKPLEGRPVVQDPLGSSIMDTALVHQQLMTEQPQYLHFKQKMP
What is the function of this protein?
Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates.
What are the official names of this protein?
Palmitoyltransferase ZDHHC11, DHHC domain-containing protein 11, Zinc finger DHHC domain-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SSL6_ARATH
Sequence: MPVFLSSRFLFFCIIVPLLISITLYQLDTFDPAHHPADSLISSTASIPPLINERFLTGAEFIGVGLLNSPEDIAYHEDSGFIYTGCVDGWVKRVKVAESVNDSLVEDLVNTGGRPLGIAFGIHGEVIVADAYKGLLNISGDGKKTELLTEEADGVRFKLPDAVTVADNGVLYFTDGSYKYNLHQFSFDILEGKPHGRLMSFDPTTKVTRVLLRDLYFANGVSLSPDQTHLVFCETPIRRCSKYYINGGRVELFIQGLPGYPDNIRYDGDGHYWIAMPSGVTTLWKLSMKYPFLRKITAMAAKYGYEPMFMENAGVLQVDLDGNPIAYYHDQALSHITTGVKIGNYLYCGSLWHSHILRLDLLKYPAQNKKL
What are the official names of this protein?
Protein STRICTOSIDINE SYNTHASE-LIKE 6, AtSSL6.
What is the protein family that this protein belongs to?
Belongs to the strictosidine synthase family.
What are the subcellular locations of this protein?
Vacuole.
Protein: P2C75_ARATH
Sequence: MTEIYRTISTGRGDDVSPTKCRERRRRRIEMRRQAAVFGEPSSSRNRDRTDMEVYSSFDVPLRKQARRSEIGGLPADIGGFLAPPAASSCQKSEAPVWKGEETEDEPLYGIVSVMGRSRKMEDSVTVKPNLCKPEVNRQRPVHFFAVYDGHGGSQVSTLCSTTMHTFVKEELEQNLEEEEEGSENDVVERKWRGVMKRSFKRMDEMATSTCVCGTSVPLCNCDPREAAISGSTAVTAVLTHDHIIVANTGDSRAVLCRNGMAIPLSNDHKPDRPDERARIEAAGGRVLVVDGARVEGILATSRAIGDRYLKPMVAWEPEVTFMRRESGDECLVLASDGLWDVLSSQLACDIARFCLREETPSSLDLNRMAQEDDNDGEQNPSRSVLAATLLTRLALGRQSSDNISVVVIDLKNSSQ
What is the function of this protein?
Negative regulator of abscisic acid (ABA) responses during seed germination.
What are the official names of this protein?
Probable protein phosphatase 2C 75, AtPP2C75, Protein ABA-HYPERSENSITIVE GERMINATION 1, Protein phosphatase 2C AHG1, PP2C AHG1.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: PRS56_MOUSE
Sequence: MPLAMLLLLLLLLSPDSQTAHGHPLYTRLSPGALQVLSAQGTQALQAAQRSAQWAIKRVLMEIQHRLHECQGPGRPRPQAPLLQDPPEPVQCGERHQGVANTTRAHGRIVGGSTAPSGAWPWLVRLQLGGLPLCGGVLVAASWVLTAAHCFAGASNELLWTVMLAEGPQGEQAEEVQVNRILPHPKFDPQTFHNDLALVQLWTPVSPEGPARPICLPQGSREPPAGTPCAIAGWGALFEDGPESEAVREARVPLLSADTCQKVLGPGLRPSTMLCAGYLAGGIDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVTVFKDWLQEQMSAGPSTREPSCRELLNWNAREEEPFTDAPGLCAFYARQCLGSESSCARLALQQCLQRRRRCELRSLAHTLLGLLRGAQELLGPRPGLRRGVSAPARSAPSLQELPGHNPREQRLYSGSRIAGTWLQKPKPERRPETKGCPGLEPLQQKLAAIQRAHAWILQIPAEHLAMNFHEVLADLGSKTLTGLFRAWVRAGLGDQRVVFSGLVGLEPSTLAHSLPRLLVQALKAFRSASLTEGEPQAPWIGADQGQRLGKERQGQLQPPVP
What is the function of this protein?
Serine protease required during eye development.
What are the official names of this protein?
Serine protease 56.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: YIBT_ECOL5
Sequence: MGKLGENVPLLIDKAVDFMASSQAFREYLKKLPPRNAIPSGIPDESVPLYLQRLEYYRQLYRPKQVEEK
What are the official names of this protein?
Uncharacterized protein YibT.
Protein: PRPH2_BOVIN
Sequence: MALLKVKFDQKKRVKLAQGLWLMNWFSVLAGIIIFGLGLFLKIELRKRSDVMNNSESHFVPNSLIGVGVLSCVFNSLAGKICYDALDPAKYAKWKPWLKPYLAVCVLFNVVLFLVALCCFLLRGSLESTLAHGLKNGMKFYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFSCCNPNSPRPCIQYQLTNNSAHYSYDHQTEELNLWLRGCRAALLSYYSNLMNTTGAVTLLVWLFEVTITVGLRYLHTALEGMANPEDPECESEGWLLEKSVPETWKAFLESVKKLGKGNQVEAEGEDAGQAPAAG
What is the function of this protein?
Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (PubMed:24196967).  Required for the maintenance of retinal outer nuclear layer thickness (By similarity).  Required for the correct development and organization of the photoreceptor inner segment (By similarity).
What are the official names of this protein?
Peripherin-2, Retinal degeneration slow protein.
What is the protein family that this protein belongs to?
Belongs to the PRPH2/ROM1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.
Protein: LEXA_ACIF2
Sequence: MDELTPRQSEILAWIRARMAEDSLPPTRAELMRAFDFRSPNAAESHLRVLARKGYILLQSGTARGIRLCASEEETGLPLIGRVAAGQPMLAEEFREGQLPVDPKLFSPGADYLLRVQGMSMRDAGILDGDILAVRHDASLTLQDGQMVVARVNGEVTVKRWKRDGKQVWLLPENPDFSPISVDLQRDSLTIEGVVVGLLRIGGNL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RECF_STRA3
Sequence: MWIKNISLKHYRNYEEAQVDFSPNLNIFIGRNAQGKTNFLEAIYFLALTRSHRTRSDKELVHFKHHDVQITGEVIRKSGHLNLDIQLSEKGRITKVNHLKQAKLSDYIGAMTVVLFAPEDLQLVKGAPSLRRKFLDIDIGQIKPTYLAELSNYNHVLKQRNTYLKTTNNVDKTFLTVLDEQLADYGSRVIEHRFDFIQALNDEADKHHYIISTELEHLSIHYKSSIEFTDKSSIREHFLNQLSKSHSRDIFKKNTSIGPHRDDITFFINDINATFASQGQQRSLILSLKLAEIELIKTVTNDYPILLLDDVMSELDNHRQLKLLEGIKENVQTFITTTSLEHLSALPDQLKIFNVSDGTISINEKKATD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYDP1_YEAST
Sequence: MSRETNFNGTKRKRSDVAEKVAQRWKSVRYSAEMENMAPVNSNNDSDDCVIVSESKIIDLTNQEQDLSERIETNDTAKGAVFKLMKSDFYEREDFMGEVEDMITLKDIFGTETLKRSILFSFQYELDFLLRQFHQNVENITIVGQKGTIMPIEARAMDATLAVILKKVKLIEITMPPFASHHTKLIINFYDNGECKIFLPSNNFTSMETNLPQQVCWCSPLLKIGKEGLPVPFKRSLIEYLNSYHLKDIDELITKSVEEVNFAPLSELEFVYSTPSKFQSSGLLSFYNKLEKLSAGTSASDTAKHYLCQTSSIGTSLSRARDENLWTHLMIPLFTGIMSPPAKDTAGRKKAEILPTNSLINEYSQRKIKPYIIFPTEQEFVTSPLKWSSSGWFHFQYLQKKSYYEMLRNKFKVFYKQDPAMVTRRRGTTPAHSKFYMHCATNSAGPCDASQVFKELEWCLYTSANLSQTAWGTVSRKPRNYEAGVLYHSRRLANTRKVTCRTFTRDRRGCAGNPTHVAVPFTLPVIPYDLAEDECFCLARHEND
What is the function of this protein?
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate.  Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue.  Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals.  Cleaves also 5' phosphotyrosyl adducts resulting from dead-end complexes between DNA and the active site tyrosine of topoisomerase II.  Contributes to DNA repair after radiation damage.  Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA.  May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups.  Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
What are the official names of this protein?
Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1.
What is the protein family that this protein belongs to?
Belongs to the tyrosyl-DNA phosphodiesterase family.
Protein: CP2R1_MOUSE
Sequence: MLELPGARACAGALAGALLLLLFVLVVRQLLRQRRPAGFPPGPPRLPFVGNICSLALSADLPHVYMRKQSRVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWIDHRRLAVNSFHYFGSGQKSFESKILEETWSLIDAIETYKGGPFDLKQLITNAVSNITNLILFGERFTYEDTDFQHMIELFSENVELAASAPVFLYNAFPWIGILPFGKHQRLFRNADVVYDFLSRLIEKAAVNRKPHLPHHFVDAYLDEMDQGQNDPLSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVHKEIDLIVGHNRRPSWEYKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWKDPDMFYPERFLDSNGYFTKKEALIPFSLGRRHCLGEQLARMEMFLFFTSLLQQFHLHFPHELVPNLKPRLGMTLQPQPYLICAERR
What is the function of this protein?
A cytochrome P450 monooxygenase involved in activation of vitamin D precursors (PubMed:12867411, PubMed:24019477).  Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol).  Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:24019477) (By similarity).
What are the official names of this protein?
Vitamin D 25-hydroxylase, Cytochrome P450 2R1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: YL154_YEAST
Sequence: MWRRRREPWEELSFLLNSLSPRNWFIRRWGLMAGRGQHLCWLRCACDGP
What are the official names of this protein?
Uncharacterized protein YLR154C-G.
Protein: CARP3_RHINI
Sequence: MKFTLISSCVTLALMTLSIEAAPSGKKVNIPLTKNKDYKPNAKNAIQKAIAKYHRHRSVSSSNSTSTDGIGYVPVTDYYNDIEYYGEVTVGTPGVTLKLDFDTGSSDLWFASSLCTNCGSSQTKYNPNESSTYARDGRTWSISYGDGSSASGILGTDTVILGGLTIRHQTIELARREASQFQSGPSDGLLGLGFDSITTVRGVKTPVDNLISQGLISNPVFGVYLGKESNGGGGEYIFGGYDSSKFKGSLTTIPVDNSNGWYGITVRGTSIGGSRVSSSFDAILDTGTSLLVLPNDVASSVAEAYGASDNYDGTFSISCDTSSFEPLVFTIGSSTFEVPADSLVYEQDGYSCIAGFGYGDYDFAIFGDVFLKNNYVVFNPEVPHVQIAPIA
What are the official names of this protein?
Rhizopuspepsin-3, Aspartate protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
Protein: PUR7_PYRAE
Sequence: MELVYEGKAKRVYKHGDFYIMEFKDEVTAGDGAVKAQAPGKGALTAELSALLFKYLSRVVETHFVEYKPPNALAVIPAEVIPVEVIVRFKAYGSQLRRMPRLRELQHLSRPLVEFHYKDDALHDPLVYPQEVVEAGLAAPQEVEAIEEMAVRAASALRDLYARAGCDFIDVKFEFGRRGGRLILVDEVSGDTFRLLCRGEHLDKEYFRKTKDVNGLIERYRDLLQITKETFTRI
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: NRAM_I78A8
Sequence: MNPNQKIITIGSVSLTIATICFLMQIAILVTTVTLHFKQYECDSPANNQVMPCEPIIIERNITEIVYLTNTTIEKEICPKLVEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGRCYQFALGQGTTLDNKHSNDTIHDRTPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCVTGYDKNATASFIYDGRLVDSIGSWSKNILRTQESECVCINGTCTVVMTDGSASERADTKVLFIEEGKIVHISPLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPVVDINVKDYSIASSYVCSGLVGDTPRKNDRYSSSYCRNPNNEKGNHGVKGWAFDDGNDVWMGRTISDESRSGYETFKVIGGWSTPNSKLQINRQVIVDSDNRSGYSGIFSVEGKSCINRCFYVELIRGREQETRVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: MRS2E_ORYSI
Sequence: MERRAQPVSAAVAPVTGRRKGAAASRKWMVVPAVGEERRVEFGKHQIMKMTGLPGRDLRVLDPVLSYPSTILGRDRAIVVRLQGVKAIITATEVLVPDHDDVLLASFLLDLRSRLSLPDAAPSTNPAAADRGNGTEQGDQGSVPGLAISGAGNAKIPPFEFKVLEVCLEHACKDLESQTRSLEKEAYPALDKLGSKVSTLNLDHVRNLKSRMVDLSGRVQKIRDELEHLLDDDMDMSEMYLTRKLSFQGLSGSLSRADSHKYASVDHDDDREEEDHDDETESGRESSVYVKPDIEELEMLLEAYFVQIDGTLNTLYHIREYADDTEDYINIMLDEKQNQLLQMGVMLTTATVVVTAGIVVVSLFGMNIHIDLMKDPETPEMVRMSNMHFWETTFGTVAGCIAIYLLAIYAGRKSKILQ
What is the function of this protein?
Magnesium transporter that may mediate the influx of magnesium.
What are the official names of this protein?
Magnesium transporter MRS2-E.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35.5) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.