PharMolix/UniProtQA huggingface dataset:
Protein: PSBM_CYAPA
Sequence: MEVNILGLIATALFIVIPTSFLLILYIQTVASAKQQEQ
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, cyanelle thylakoid membrane; Single-pass membrane protein.
Protein: Y2140_SACS2
Sequence: MEDPIKAIEEIFKKADQIFKFLDVKVINLEKGRAVVEIPYKEEFTRRGGVLHGGIIMSAIDITGGLAALTVNDAMDQVTQELKINFLEPMYKGPFTIEGKVLRKGSTVIVVEIEFKDADGKLGAKAIGSWYILRTKVQAK
What are the official names of this protein?
Putative esterase SSO2140.
What is the protein family that this protein belongs to?
Belongs to the thioesterase PaaI family.
Protein: HM13_HUMAN
Sequence: MDSALSDPHNGSAEAGGPTNSTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCARGKNASDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSHTISPFMNKFFPASFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGEVTEMFSYEESNPKDPAAVTESKEGTEASASKGLEKKEK
What is the function of this protein?
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm.  Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810).  May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199).  Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365).  Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945).  May play a role in graft rejection (By similarity).
What are the official names of this protein?
Minor histocompatibility antigen H13, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Multi-pass membrane protein.
Protein: NRP1_MOUSE
Sequence: MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVLGVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYPERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPTDLDKKNTEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA
What is the function of this protein?
Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity).  Mediates the chemorepulsant activity of semaphorins (PubMed:26503042).  Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity).  Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity).  Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis.  Regulates VEGF-induced angiogenesis (By similarity).  Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042).  Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).
What are the official names of this protein?
Neuropilin-1, A5 protein.
What is the protein family that this protein belongs to?
Belongs to the neuropilin family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass type I membrane protein. Cell membrane; Single- pass type I membrane protein. Cytoplasm.
Protein: O1634_CONCL
Sequence: MKLTCVLIVAVLILTACQVIAADSSCWFCSTGFNKCCESTGDCMTYPSEYNASCPEA
What is the function of this protein?
Probable neurotoxin.
What are the official names of this protein?
Conotoxin Cal6.34, O1_cal6.34.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ZNUC_JANSC
Sequence: MSLITVENLSVRYGANTVLRNVALTVEPGEIVTIVGPNGSGKTSLLKAIIGAARPAAGQVTLRPGLRIGYVPQRLHIDATLPITVERFMGLTARVTREDCMAALKIAAVPDLLKRQMSQLSGGQFQRVLLARALINKPDVLLLDEATQGLDQPGSAAFYRQIEDVRRETGCAVLMISHELHVVMSASDRVICLNGHVCCAGTPAVVASAPEYRALFGTGTGGALALYRHDHDHNHDHDHEAAE
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FLPA_METVS
Sequence: MEKIKVKEIFSNVYGVDLGDGLKRIATKSLAPGKRVYGEKLIYSENKEYRIWNPNKSKLGAAIINGLKKMPIKKGTKVLYLGASAGTTPSHVSDISEDTIVYAVEFAPRIMREFIDSCNERINLIPILGDANRPFEYSNIVGKVDVIFEDVAQPNQAEILVKNAKWFLNKDGYAMISIKARSIDVTKNPKEIFLEQKKILIEGGFDIVDEINIEPFEKDHIMFVGIWKGN
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: ORFB_WDSV
Sequence: MFSDSDSSDEELSRIITDIDESPQDIQQSLHLRAGVSPEARVPPGGLTQEEWTIDYFSTYHTPLLNPGIPHELTQRCTDYTASILRRASAKMIQWDYVFYLLPRVWIMFPFIAREGLSHLTHLLTLTTSVLSATSLVFGWDLTVIELCNEMNIQGVYLPEVIEWLAQFSFLFTHVTLIVVSDGMMDLLLMFPMDIEEQPLAINIALHALQTSYTIMTPILFASPLLRIISCVLYACGHCPSARMLYAYTIMNRYTGESIAEMHTGFRCFRDQMIAYDMEFTNFLRDLTEEETPVLEITEPEPSPTE
What are the official names of this protein?
ORF-B protein.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Multi-pass membrane protein.
Protein: HV02_XENLA
Sequence: DFIIFFIFMFFSPSCILSQTLQESGPGTVKPSESLRLTCTVSGFELSSYHMHWIRQPPGKGLEWIGVIATGGSTAIADSLKNRVTITKDNGKKQVYLQMNGMEVKDTAMYYCAREYASGYNFDYWGQGTMVTVTS
What are the official names of this protein?
Ig heavy chain V region XIG14.
Protein: BLMP1_CAEEL
Sequence: MGQGSGDDGVPPAPFSSAAAAAHSPPHSPLSVGVSSASSATSSSSTPPSSTSPAGVSASGARNVETDWKQSGDENLAELCIFHVPDKSVSLPNPKRAECTLPMNLILKSSSKNRKKSSIWSSDHIPRGVRFGPLVGEIRLVDVDTALVCPAEASMAGGGPAQEDVPFDEAPEEWKIYSPSGGRLNKTICVKDDARSNWMKYVAAAEEEDFQNLVAAQIGNDIYFYTVKKIEANTELSFWFSRDYARKLNYSTRPYVRVRRPATQLIPSAPPASASTAIASLAETIVAIDYSVKKLIESPIDTLSTDASSASDEEMIDVEEQESCTRPVAEVTRPNVIQNPVVRPVATKVNNFPGIPVRLGNFYASPLVDFKEFMRKSLQLKLVDTSMFVSPVAQTTAAITATGGRSGQPIDVQPVLAATAGAHFGNYAAIYGSQDFQHELSKPLYTSASPAFGGGGGMGGGFGMGGSAHTSSFHQLPFVNHSSSSHNDSSFNGVPNYVQQQENGKTRYACKDCNKTFGQLSNLKVHVRTHTGERPFKCEICTKEFTQLAHLQKHHLVHTGERPHRCDICDKRFSSTSNLKTHLRLHNGQKPYTCDVCDAKFTQYVHLRLHKRLHANERPYSCGTCGKKYISPSGLRTHWKTTTCKEEDMKDSMRDDLMDIKGEIDEGSMSGSGYGNLGIFENTLNSELKRPLMPIETIYSKYNLPNASLLGQGPSGMQEQQAPPPTSQQQQHMMYGNTMGHMGQGSHLQGPPPPPQHFQMDHSGMQNGGGIPHQHQLIQGGPSSGSGQQQHPQHNGIHRLPDLKNPLLPSLGLPHYP
What is the function of this protein?
Transcription factor which binds to enhancer elements in the promoter region of genes (PubMed:26234645).  Regulates the expression of the transcription factor bed-3 to control vulval development (PubMed:26234645, PubMed:32417234).  Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage (PubMed:24613396).  Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning (PubMed:24968003).  Plays a role in male tail tip morphogenesis (PubMed:21408209).
What are the official names of this protein?
B lymphocyte-induced maturation protein 1 homolog.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes to the nucleus and cytoplasm in hyp8-11 tail tip cells throughout development, but cytoplasmic localization is most prominent during male tail tip retraction.
Protein: LIPB_NOSS1
Sequence: MIRSNKPPENNCLLYNKGLMPYLAAHAWQRSLLRQRIDYPNLEDVLILLEHPPVYTLGQGSSLEFLKFDPNQSEFEIHRIERGGEVTYHCPGQLVGYPILNLHRHRQDLHWYLRQLEEVIIRVLAVYDLKGDRLPSLTGVWLEGRKVAAIGIKVSRWITMHGFALNVCPDMTGFSRIVPCGITDKPVGSLAQWIPGITCEEVRVHVVQAFAEVFGLELVDS
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_LEGPA
Sequence: MAKFELYAEVDVSISGHQYPIIICRNGLIDPDLINRFITSKQVLIVTNRTVAPLYLGHLQSVLPSKQCDVVILEDGEEHKNQRSLFTIYDSLIQNKHHRDTSIIALGGGVIGDMAGFAASTYQRGVRFIQLPTTLLAQVDASVGGKTAINHPAGKNMIGSFYQPQAVIIDLNTLKTLPEREFRAGIAEMIKYALLVGGSFFERIQEVLQQGLTVHSPELPLLIAECCQVKAKIVEQDERESGLRALLNLGHTFAHALETYTDYKKWLHGEAVAIGLYCAAVLSEKKGLLDKPIVDQVEKMLIHAGLPHKIPNSIDLIQLRELMSLDKKIKNNCLRFVMIKKPGACYIDDSVTEDCLHNTLINVVEGEQK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_BAUCH
Sequence: MAKTILAARKHIKKQVVDGIAHIHASFNNTIVTITDRQGNTLGWATAGNSGFRGSRKSTPFAAQVAAERCAEAVKDYGIKNLEVMVKGPGPGRESTVRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: Y137_METJA
Sequence: MWGEKMDPLSGFISSLIWWLLFFYLIMAPQIQYKQLQLARLKILRELSNKRNSTVITMIHRQESIGLFGIPVYKFITIEDSEEILRAIRAAPKDKPIDLIIHTPGGLVLAATQIAKALKAHPAETRVIVPHYAMSGGTLIALAADKIIMDENAVLGPVDPQLGQYPAPSIVKAVEQKGADKADDQTLILADIAKKAINQVQNFVYNLLKDKYGEEKAKELSKILTEGRWTHDYPITVEEAKELGLDVDTNVPEEVYTLMELYKQPVRQRGTVEFMPYPVKQENGAK
What are the official names of this protein?
Uncharacterized protein MJ0137.
What is the protein family that this protein belongs to?
To M.jannaschii MJ1495.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TRPD_XANOM
Sequence: MPITPQEALQRTIEHREIFHDEMVGLMRQIMRGEVSDMMVAAILTGLRVKKETIGEIAGAATVMREFSRRVDVSDHQHMVDIVGTGGDGSHTFNISTCAMFVAAAGGAKVAKHGNRSVSSKSGSADALEALGAVIELQPEQVADALAQTGIGFMYAPLHHPSMKVVAPVRREMGVRTIFNILGPLTNPAGSPNILMGVFHPDLVGIQARVLQELGAERALVVWGRDGMDELSLGAGTLVGELRDGQVREYEVHPEDFGIAMSASRNLKVADAAQSRAMLLRVLDNVPGPALDIVALNAGAALYVAGLAGSIADGVLRARAVLADGSARARLDAYVAYTHQLAGQP
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: Y391_BACCN
Sequence: MDLSVKSQENVEHMVEAIKEKLRMVNAGAMKAANFDEDMYEDLRDIYDHVMKRETFSISEMQAITEELGTLMKK
What are the official names of this protein?
UPF0435 protein Bcer98_0391.
What is the protein family that this protein belongs to?
Belongs to the UPF0435 family.
Protein: YCED_ECOLI
Sequence: MQKVKLPLTLDPVRTAQKRLDYQGIYTPDQVERVAESVVSVDSDVECSMSFAIDNQRLAVLNGDAKVTVTLECQRCGKPFTHQVYTTYCFSPVRSDEQAEALPEAYEPIEVNEFGEIDLLAMVEDEIILALPVVPVHDSEHCEVSEADMVFGELPEEAQKPNPFAVLASLKRK
What is the function of this protein?
Plays a role in synthesis, processing and/or stability of 23S rRNA.
What are the official names of this protein?
Large ribosomal RNA subunit accumulation protein YceD, 23S rRNA accumulation protein YceD, G30K.
What is the protein family that this protein belongs to?
Belongs to the DUF177 domain family.
Protein: G6PI_PSEE4
Sequence: MAYYRTPHDVTALPAWQALQQHRDAMQGFSMREAFAADGKRFEEFSLSSCGLFLDYSKNLINEQTRDLLVGLANEVGLADAIKSMFSGEIINASEGRPVLHTALRRPVGDKLSVNGVNVMPDVHKVLNQITELVGRIHDGLWRGYSEKPITDVVNIGIGGSFLGPELVSEALLPYAQRGVRCHYLANIDGSEFHELSANLRAETTLFIVSSKSFNTLETLKNATAARTWYLAQGGSEAELYRHFIAVSSNKAAAVAFGMREENIFPMWDWVGGRYSLWSAIGLPIALAIGTANFKELLSGAYTMDQHFQTAPFDKNMPVLLALLGVWYGNFWGAQAHAILPYDHYLRNITKHLQQLDMESNGKSVLQDGSPVKTDTGPVIWGGVGCNGQHAYHQLLHQGTQLIPADFIVPVVSFNPVADHHQWLYANCLSQSQALMLGKTRDEAEAELRAKGMNEDDIAKLAPHKVIPGNRPSNTLVVERISPRRLGALVAMYEHKVFVQSVIWGINAFDQWGVELGKELGKGVYQRLVGSLEDSAEDGSTQGLINYFRGRHRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_RICB8
Sequence: MANHSSAKKAARQTVKKTLVNKRRASAIKTFVKKVLHEINQGNKEEANSALVIAQSKIMQGVKKNIIKLNTASRKISKLSKKIKTMN
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: NTPPA_SHEON
Sequence: MNLVLASTSPRRKELLTHIGLGRSDFTFEQVAPDIDETPRSGELPRDYVQRLAAEKAQAGLALCSDMSQPAVLGSDTIVVLENEILGKPVDDADAKRVLRALSGRAHTVMTAVALANANHTAMRLVETLVRFCVLSDADIDAYVASQEPMDKAGSYGIQGLGGCFVESIDGSYSCVVGLPLVETRQLLSEAGII
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_METI4
Sequence: MPEYIKRKFGDQTIVFETGKLAKFADGSVTVSYGETAVLVTAVSVTELKEDQDFLPLQVEYREKAAAAGRFPGGYFRKEGRPTDKEILTSRMIDRPLRPLFPKGYFYETQILGTLLSADGQNDPDVMAINGASAALMVSDIPFYGPVGAVRIGQIDGRWIINPTHREREISDIDLVYVGSEHYPLMIEGSAREFPEEEFVKALEFAHQHVQEVIAAQKELAEKVGKPKRSCVLFEENLAITNRLAELYSSQLQDALYTSSKTERQKKLAKLKEELTAKILEEFPTATPREITSSYDSLQKTIFRTNVLETKRRCDGRGPEDIRPIAIETSVVPRSHGSSLFCRGETQALCMATLASLNEAQELDAYGGGEQSKRFLLHYFFPPFSVGEVGRITGQSRREIGHGALAERSLLPVIPSETDFPYAIRVSSEILESNGSTSMATVCGGSLALMDAGVPLKTSVAGISVGLVKGKEEDFDWSRYCLLTDILGLEDHYGDMDFKIAGTRKGITGFQLDLKLRGIPLDVMAKAIFQSQKARMVILDCMDKVINAPRAEISKHAPRIEKIKIHPDKIGLLIGPGGKTIKKISAESGAEITIEDDGTVMIYSSSADSLEAAREMIEDMVGEVTVGGIYRSKVVSVKDFGCFIEIKGKGEGLVHISELSDTPVRRVDQVVRVGEEIWVKCIGVDEKGRYKFSRKAAMKELHAKRMQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_SORMA
Sequence: MATHNIVVFGGDHCGPEVVVEAIKVLKSIETNSPSAGKFNLQNHLLGGASIDKHHDPLTDEALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDSSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGSGYACDTEPYSRAEIERIARLAGFLALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTILSVAMMLRYSLNLPKEADAVEAAVKAAIDNGTKTKDLGGSATTSDMGNAVVAELEKILKA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, IMDH, Beta-IPM dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GALT_LACLM
Sequence: MSIYQSIQDFISLALQNGTIEPLDELYHRNQLLHFLGLNDWAEVDKEVHETNSLILMDQLLAIANENNVIAKGQDEFYEAALMNFMTPRPSKINHDFWEKYQASPDDATQYFYELAQQVNQVKTRDIARNIAFSHLTKYGKLEITINLSKPEKDPKAIAAAKLVKASSYPACQLCLENEGFYGLGNKPARSNHRIIQVSINGEDWGFQYSPYAYFNEHSILLNAKHQPMEINKRAFDNLLGFLDKFPNYMIGSNADLPIVGGSILTHDHYQAGRHDFPMAKAELRETIELAHFPEVSCGIVNWPMSVLRLASENQVELSKAADDFLKKWQVYSDESLQIKAKSTDGTPHHTITPIARIRDGKYELDLVLRDNNTNEKYPDGIFHPHPALHHIKKENIGLIEVMGLAILPARLGTELLEVEKYLLNQDNQMDEIHKAWAEQLKNEEHFTRETVHATVQGAVGEVFEEVLKDAGVFKDTQEGHEGFRKFIDFVNQ
What are the official names of this protein?
Galactose-1-phosphate uridylyltransferase, Gal-1-P uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_SHESM
Sequence: MGDNKNNGDSGKLLYCSFCGKSQHEVRKLIAGPSVYVCDECVELCNDIIREEIKEISPKRDNDKLPTPHELRAHLDDYVIGQDRAKKVLSVAVYNHYKRLRNSSPKDGVELGKSNILLIGPTGSGKTLLAETLARSLNVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLEKVIEQRAHVGSGIGFGAQVKGEKDKATISQTLSQVEPEDLVKYGLIPEFIGRLPVVATLTELDEEALVQILSEPKNALTKQYNALFEMEGVELEFREDALKAIAHKAMSRKTGARGLRSIVEGILLDTMYDIPSIEGVVKAVVDESVVNGESAPILIYERNDAQAASGEQ
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: LDHD_LEUMC
Sequence: MKIFAYGIRDDEKPSLEEWKAANPEIEVDYTQELLTPETAKLAEGSDSAVVYQQLDYTRETLTALANVGVTNLSLRNVGTDNIDFDAAREFNFNISNVPVYSPNAIAEHSMLQLSRLLRRTKALDAKIAKRDLRWAPTTGREMRMQTVGVIGTGHIGRVAINILKGFGAKVIAYDKYPNAELQAEGLYVDTLDELYAQADAISLYVPGVPENHHLINADAIAKMKDGVVIMNAARGNLMDIDAIIDGLNSGKISDFGMDVYENEVACSMKIGLVKNSPDAKIADLIARENVMITPHTAFYTTKAVLEMVHQSFDAAVAFAKGEKPAIAVEY
What are the official names of this protein?
D-lactate dehydrogenase, D-LDH, D-specific 2-hydroxyacid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: MISP_PONAB
Sequence: MDRVTRYPILGIPQAHRGTGLVLDGDTSYTYHLVCTGPEASGWGQDEPQTWPTDYKAQQGVLRQGVSYSVRAYPGQPSPRGLHLETGEDEGLKVYRLGARDAHQGRPTWAVHPEDGEDEEMKTYRLDAGDAVPRGLCDLERERWAIIQGQAVRKSGTVATLQAAPDHGDPRTPGPPRSTPLEENVVDREQIDFLAARQQFLSLEQANKEVPHSSPARGTPAGPSPGVSQAPKAFNKPHLVNGHVVPTKPQGKGVFREENKVRAVPAWASVQVADDPGSLAPVESPGTPKETPIEREIRLAQEREADLREQRGLRRAADHQELVEIPSRPLLTKVSLITAPRRERGRPSLYVQRDMVQETQREEDHRREGLHVGRASTPDWVSEDPQPGLRRALSSDSILSPDSILSPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEPSAFGAFSKPSGLSTVDTEAATSPKATMSPRHLSESSGKPMSTKQEPWKLPRGSPQANRGVVRWEYFRLRPLQFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREREVAEERRNALFPEVFSPTPDESCDQNSRSSSQASGITGSYSVSESPFFSPIRLHSSLAWTVEDPVDSAPPGQRKKEQWYAGINPSDGINSEVLEAIRVTRHKNTMAERWESRIYASEEDD
What is the function of this protein?
Plays a role in mitotic spindle orientation and mitotic progression.  Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning.  May link microtubules to the actin cytospkeleton and focal adhesions.  May be required for directed cell migration and centrosome orientation.  May also be necessary for proper stacking of the Golgi apparatus (By similarity).
What are the official names of this protein?
Mitotic interactor and substrate of PLK1.
What is the protein family that this protein belongs to?
Belongs to the MISP family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis (By similarity).
Protein: SYC_RICPU
Sequence: MQIQFHLYNTLSRTKEVFNPQDQANVKMYVCGPTVYYNPHIGNSRSGVVYDLLYRIVIKIFGEKAVKYVRNITDVDDKIIDRAALLGVTIDELTDKVTKEFHKNMAYLGCMLPSIEPKATKHIDVMIAIIERLIAKDHAYIADNHVYFDVLSAPNYTELSNRNLEEMFEGVHVENSKTKKNPQDFVLWKPAKQNESANMNFESPWGLGRPGWHIECSAMSYKYLGENFDIHGGGADLIFPHHTNEIAQSRCAFPSSTYAKYWVHNGFLTVNGEKMSKSLGNFITVRDLMDKQIQGEVVRLFLLSSHYRRPLDYNDKAIEDAKKTLDYWYRAIENINVQKIDLPHDFMQSLLDDMNTPLAVKIINDYAKGVFISKTEEERQLNASAIITCANFIGLMNKTPHEWFNSGVDELYINELVNKRLEAKKQKNWLLADQIRNQLLEEKIILEDQPDGTTIWRKE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.