PharMolix/UniProtQA huggingface dataset:
Protein: ZFPP_THEFY
Sequence: MGLLRIPLYRLYERRLERALSNAPKPRHVGVILDGNRRWARLSGLSSPKEGHRAGAEKIFELLDWCDEVGVQVVTLWLLSTDNLARPPEELEPLFEIIENTVRRLCNEGRRVNPMGALDLLPASTAQVMKEAGTTTERNPGLLVNVAVGYGGRREIADAVRSLLLEEAAKGTTLEELAERLDLDDIAKHLYTRGQPDPDLLIRTSGEQRLSGFLLWQSAHSEFYFCEVFWPAFRKIDFLRALRSYSVRQRRFGC
What is the function of this protein?
Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP).  Only geranyl diphosphate (GPP) can be used as isoprenyl acceptor.
What are the official names of this protein?
(2Z,6E)-farnesyl diphosphate synthase, Cis-prenyltransferase, Short-chain Z-isoprenyl diphosphate synthase, Z-FPP synthase, Z-FPPS, Z-Polyprenyl diphosphate synthase, Z-isoprenyl diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family. Z-FPP synthase subfamily.
Protein: HUTU_RALSO
Sequence: MNTMTDAAHLAADPRYDAAREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLVVYGGIGRAARDWACFDKILETLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVPKWANWEHFNALDRKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAEAGRQHYSDRPSALLKQGLSPEGTAPGSGRSSAQVPGSHLAGRWILTAGLGGMGGAQPLAATLAGAVSLTIECQQSSIDFRLRTRYLDKQARDIDDALNLIRHHCERGEAVSIGLLGNAAELLPELVRRARAGGLKPDLVTDQTSAHDLVNGYLPAGWTVEQWRAAQRDPAQHAHLSAEAARSCAVHVQAMLDFQSMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFCEGRGPFRWVALSGDPEDIYKTDAKIKELFPHNAHVHRWLDMARERIAFQGLPARICWLGLGERHAAGLAFNEMVRKGELKAPIVIGRDHLDTGSVASPNRETEAMRDGTDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTDAAARRLARVLVNDAGSGVMRHADAGYETAVACAKRNGLKLPMIG
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPAB4_BOVIN
Sequence: MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit RPABC4, RNA polymerases I, II, and III subunit ABC4, DNA-directed RNA polymerase II subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS14_SHESW
Sequence: MAKTSMKAREVKRAQLVAKYAEKRAALKAIIVSPASSDEDRWDAVLKLQALPRDSSASRKRNRCNQTGRPHGFLRKFGLSRIKLREATMRGEVPGLRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: ELL3_MOUSE
Sequence: MEGTQEALSGKMRLLFTPAARTSLLMLRLNEAALRALQECQQQQVRPVIAFQGHRGYLRFPGPGWSCLFSFIVSQCGQEGTNGGLDLVYQRLGRSGPNCLHCLGSLRERLTIWAAMDTIPAPLLAQEHLTEGTRESESWQDTGDEPEGHPQLAPDEVSDPLASHHEQSLPGSSSEPMAQWEMRNHTYLPSREPDQSLLSPASQKRLDKKRSAPITTEEPEEKRLRALPLASSPLQGLANQDSQEGEDWGQDEDEEGDEDGDSRLEQSLSAPSASESPSPEEVPDYLLQYRAIHSTEQQQAYEQDFETDYAEYRILHARVGAASQRFTELGAEIKRLQRGTPEHKVLEDKIVQEYKKFRKRYPSYREEKHRCEYLHQKLSHIKGLILEFEEKNRGS
What is the function of this protein?
Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification.  Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.  Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.  Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner.  Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation.  Required for recruitment of P-TEFb within SEC during differentiation.  Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells.  Promoting epithelial-mesenchymal transition (EMT).
What are the official names of this protein?
RNA polymerase II elongation factor ELL3.
What is the protein family that this protein belongs to?
Belongs to the ELL/occludin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TOK1G_HADVE
Sequence: MNTATGFIVLLVLATVLGGIEAGESHMRKDAMGRVRRQYCVPVDQPCSLNTQPCCDDATCTQELNENDNTVYYCRA
What is the function of this protein?
Toxin that may inhibit ion channels.
What are the official names of this protein?
Omega/kappa-hexatoxin-Hv1g.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 08 (Shiva) family. 02 (omega/kappa toxin) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPB_SACHY
Sequence: MRTNPTTSRPGVSTIEEKSVGRIDQIIGPVLDITFPPGKLPNIYNALIVKSRDTADKQINVTCEVQQLLGNNRVRAVAMSATDGLMRGMEVIDTGTPLSVPVGGATLGRIFNVLGEPIDNLGPVDTSATFPIHRSAPAFIELDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEKNIEESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKKGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLASKGIYPAVDPLDSTSTMLQPRIVGNEHYETAQRVKETLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEASTKAINLEEESKLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ASK7_ARATH
Sequence: MSTKKIMLKSSDGKMFEIEEETARQCQTIAHMIEAECTDNVIPVSNVTSEILEMVIEYCNKHHVDAANPCSDEDLKKWDKEFMEKDQYTIFHLMNAAYDLHIKSLLALAYQTVADMVNDNKWAFE
What is the function of this protein?
Involved in ubiquitination and subsequent proteasomal degradation of target proteins.  Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex.  The functional specificity of this complex depends on the type of F-box protein.  In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity).
What are the official names of this protein?
SKP1-like protein 7, AtSK7.
What is the protein family that this protein belongs to?
Belongs to the SKP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU4M_BRALA
Sequence: MNHLVLGYVGLVIGVIVTKKSMVWRVGQVGSVLLMLPATVLVNMNMTISNVSYMMTSDFVSLGLTVLSIWLLPLMLLASQQHMVSESLIYQRVFVGCQVFLTGALVLAFMASDLLLFYIAFESTLLPTLMLITRWGAQKERYQAGTYFMFFTLVGSLPLLICLIGQYQMVGSLALDLSYEGVFQLSYLVNFWWVGCILAFLVKLPLYGVHLWLPKAHVEAPIAGSMVLAGVLLKLGGYGMMRVSLMWGATAMLSSEVFLALALWGIVVMGGICLRQTDLKSLIAYSSVGHMALVVGGVLTGVAWGYNGAMVLMIAHGLVSSCLFCLANLWYERSSTRNLSGSRGLIMIFPLISLGWFLMSLMNMALPPAINLFGELVAMVALYNWSPYSIVYMSLGAVLTAAYSLYLFGMSQWGNTMKNYKNLYTITSREYLLTTLHLVPAIYLIFYLGLMF
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: Y1511_LISMC
Sequence: MAEEHNHNHEEENIIWITNEEGKEEAYEILFDFDSEDFDKSYVLYFPAGKGEDEEIEILASSYIQDEEGKQGQLKPVETDEEWDMIEEILATFLADEDEE
What are the official names of this protein?
UPF0473 protein Lm4b_01511.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: TKN1_RAT
Sequence: MKILVAVAVFFLVSTQLFAEEIGANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
What are the official names of this protein?
Protachykinin-1, PPT.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRLR_COLLI
Sequence: MKQKLRSSVQIILLFALTAVGLTGQSYPGKPKIIRCRSLEKETFSCWWKPGSDGGLPTNYTLFYSKDSEEKIYECPDYGMSGPNSCYFDKNHTNPWTTYNITVMAMNEIGSNSSDPQYVDVTSIVQPDAPVNLSLETKTSASTTYLLAKWSPPPLADVTSNSHVYRYELRLKPEEKEEWETVSVGVQTQYKVNRLQAGVKYVVQVRCVLDIGEWSEWSSERHIHIPNGESPPEKPTIIKCRSPEKETFTCWWKPGSDGGHPTNYTLLYSKEGEERVYECPDYKTAGPNSCYFDKKHTSFWTIYNITVKATNEIGSNVSDPLYVDVTYIVQTDPPVNVTLELKKTVNRKPYLVLTWSPPPLADVRSGWLTLDYELRLKPEEAEEWETIFVGQQTHYKMFSLNPGKKYIVQIHCKPDHHGSWSEWSLEKYLQIPTDFRIKDMVVWIIVGVLSSLICLVMSWTMVLKGYRMIAFILPPVPGPKIKGIDTHLLETGKSEELLSALGCHGFPPTSDCEELLIEYLEVEDSEDQQLMPSHDNGHPSKNAKMIAKETDSDSGRGSCDSPSLLSEKCRESRAILSTLQTQDIRDVQENNGRRHWETQCIASEQKILLFNNESTKSPIWPAAQLPDNQPPMFAYHSTVDVHKITLCTIDVNIAPVLVENEEQHQPQYPITETVHDNMEKHREVENLYSKTDQTTVQVKQNRPNDKSPFSKPKLMDYVEVHKVRQDEVAAVLLKHKENSGKIEKYTVPGTSKEYTKVSTVVDHNILVLMPDSRIQHIPVSQEPAMEMSQNLQQGQTEKNMSYCLTVPSECKRETSASEYMDPSSFIPAFK
What is the function of this protein?
This is a receptor for the anterior pituitary hormone prolactin.
What are the official names of this protein?
Prolactin receptor, PRL-R.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 1 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PDXJ_LEPBA
Sequence: MTQLSVNVNKIATLRNSRGGSLPSVLKLSELILDSGAHGITVHPRSDERHITKQDVFELQEFLRTYNEKITKLGISKKEYNIEGEPSERFLDLVLKAKPDQATLVPVKPGEITSDHGFQFADQKTFSTLKPIVEAIRKEGIRVSLFMETDFTFYDQVVALGAERIELYTGPFAHAFDLSEEKGKEIFTDYQRAAIEANKLGLAVNAGHDLDTNNLRVFAKLPYLKEVSIGHRLMAQSLVDGLETTVKSYLKVLSLGNETE
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCP_BACCN
Sequence: MKTVLLTGFDPFGGEKINPAWEVAKALHEKEGNGYKVISKQIPTVFHKSIEQLESYIDEFNPELIICIGQAGGRADITVERVAINVDDARIPDNENYQPIDVPIIEDGPVAYWSTLPIKAIVKKLREEGIPASVSQTAGTFVCNHLFYGLMHRLAIKNKSTRGGFVHIPFLPEQASLHANQPSMSLSTIIAGIQLLIEVALQVEKDIVECGGTTH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METN_FRATH
Sequence: MIQIKNLKKEYRTNNTSNLVLDNINLEIKQGEIFGIIGHSGAGKSSLLRCLNLLEQPTDGSIFIADENITKKNSKQLREFRKKVAMIFQHFNLLSSRNVFENIALPLEIQGIPKSEIKKRVFELLDLVELPNKANAYPQELSGGQKQKVAIARALALNPLVLLSDEATSALDPTSTKQILALLKRLNKELGLTIVLITHEMDVVRKICDRVAIIDKGRIAEMGKTLDVFLNPQAPVTRSFVETSIHTKVPDFIAKKLQDNPYSYDNTYPVVQLTFYGDKGKMPIIAEISRQFNATASIIQANIETIQDQIVGIAICHITGERQDWENALRFLSNQDVNLKVLGYATADNI
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y711_TREPA
Sequence: MLVMSITFSFVAVALLVYFYVKVRTSFSPDAYAKTMQQEVIKMIRDIRYEADIAVQMLEKKIGECNQVVRTIDRKLTLLNEEILKEHTARTLFRASGAGQETREEVCARPEHRSAPSRAGSSAAKPTPTKRGTIEVYNEKIIRDNGLRAESPLLKDAIIALSEKGLAPEFIAEKTGKPLGEVQLLINLSR
What are the official names of this protein?
Uncharacterized protein TP_0711.
What is the protein family that this protein belongs to?
To B.burgdorferi BB0265.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ILVC_PYRAR
Sequence: MAKIYRDVDASLEPLKGKTIAVIGYGIQGRAQALNLRDSGLNVILGLRRGGKSWDQAVAEGFRVFEIGQAVAKADVVMVLIPDMEQPKVWEEQIEPNLKPGTVVDFAHGFNIHFGLIKPPPNVDVVMVAPKGPGRAVREEYLSGRGVPALVAVYQNYSGRAMEYALAIAKGIGATRAGVIETTFAEETETDLIGEQTVLVGGLMELIKKGFETLVELGYQPEVAYFEVLNEAKLIMDLIWQRGIYGMLNGVSDTAKYGGLTVGPKIIDESVKQRMREAAARVRSGEFAKEWVTEYNRGGPTLRKLMEEVKNHQIEKVGIEMRRLLFGQ
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SYH_THEKO
Sequence: MARLDKVKGTRDLLPEEMAKRRWVFERIREVFEGFNFQEVLTPTFEYTELFKLRSGEEVVKQLYAFQDKGGRDISLRPDMTSSVARLYVNRFQNAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVELIGSDRVEADAEVIALFTQSYLAVGLEDFTVNIGDRILLDEFAKMLGVEDDIGLMRLIDKKDKMSREEFVGALREFGLNDDGVEKVLSLIEIKGLPDEVLPKAEELFTSEEAKAEIKRLYELVDLLDAYGVSKWVRIDLGIARGFDYYTSVVFEAIAPNDLGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPEIKLRPDVYVIPIGDDREVKKTAIEITQGLREATVRADIELTGRKLRKALDYAGKLGVPYVVLVGKKDLEAGKVTLRDMKSGEQKSIEKERAVEEILNILGV
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_METSB
Sequence: MPFVIAYPVIDPVLLSIGPLPIRWYALAYIAGLVIGWAYARHLVARASFWGGRVRPDLGVIDDLLVYTALGVILGGRLGYVVFYNPAFYLSHPLDVFKLWQGGMSFHGGLVGAGVGVMLLARRRGLPTLALGDIVSAVAPIGLFLGRIANFIKPELWGRPTDVPWAMVFPGAGDLPRHPSQLYEAAAEGALLFLLLFVAVRLGALKRSGLVTGLFAIGYGCARILCEFFREPDPQLGFLFGGATMGMLLSLPLIAAGLALVAFAYRREAVPA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RM18_BOVIN
Sequence: MALRSRSWELLPVCRNPGCRVAAFSTSAKPVVKPEADPVGNEAVAPEFTNRNPRNLELLAVARKERGWGTVWPSREFWHRLRVIRSQHHIEALVEHRNGQVVVSASTREWAIKKHLYSTKSVVACESVGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQIGMIEGGVVLQEPRRIYE
What is the function of this protein?
Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA.  The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST).  Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).
What are the official names of this protein?
39S ribosomal protein L18, mitochondrial, L18mt, MRP-L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS18_BUCAT
Sequence: MARYFRRRKFCRFTAEGVQEIDYKDIAVLKNYITESGKIVPSRITGTRAKYQRQLSRAIKRARYLALLPYTDQHR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TRPG_ASPNG
Sequence: MADSGLVDHSPHHPTKAAQLSTASNVILIDNYDSFTWNVYQYLVLEGATVNVFRNDQITLEELIAKKPTQLVISPGPGHPETDAGISSAAIQYFSGKIPIFGVCMGQQCIITCFGGKVDVTGEILHGKTSPLKHDGKGAYEGLPGSLAVTRYHSLAGTHATIPDCLEVSSSVQLADDSNKDVIMGVRHKKLAVEGVQFHPESILTEYGRIMFRNFLKLTAGTWEGNGKHFGEQSSTTKATVPSNPPPKTDKKLSILERIYDHRRAAVAVQKTIPSQRPADLQAAYDLNLAPPQIPFPARLRQSPYPLSLMAEIKRASPSKGMIAENACAPAQARQYAKAGASVISVLTEPEWFKGSIDDLRAVRQSLEGMTNRPAILRKEFVFDEYQILEARLAGADTVLLIVKMLSVELLTRLYHYSRSLGMEPLVEVNTPEEMKIAVDLGAEVIGVNNRDLTSFEVDLGTTSRLMDQVPSSTIVCALSGISGPKDVEAYKKEGVKAILVGEALMRAADTATFIAELLGGSSQTVSSESRRSPLVKICGTRSEEAARAAIEAGADLIGIIMVQGRTGCVPDDVALPISQVVRSTPKPASQALHTSQEPPAATSVEYFDHSAKILRHPSRALLVGVFQNQPLDYILSQQQKLGLDVVQLHGSEPLEWAKLIPVPVIRKFGLDEPAIARRAYHSLPLLDSGVGGTGELLDQSRVQNVLDKDCGLRVILAGGLDPTNVAGIVQKLGESGRKVVGVDVSSGVESDGAQDLNKIRAFVQAVRGL
What is the function of this protein?
Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
What are the official names of this protein?
Multifunctional tryptophan biosynthesis protein.
Protein: PLK4_RAT
Sequence: MAACIGERIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSESEARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMSRNPSTKSKDLGTVEDSMDSGHATLSTTITASSGTSLSGSLLDRRRLLVGQPLPNKITVFQKNKNSSDFSSGDGSNFCTQWGNPEQEANNRGRGRVIEDAEERPHSRYLRRAHSSDRSNPSNQSRAKTYSIERCHSVEMLSKPRRSSLDETKHSSNHHCLGKTPFPFADQTPQMEIVQQWFGNLQMNGETSEHNTISPNRDFQDYPDVQDTLRNTWTDTRASKNSDNSANVHPAKQLSTMKYMTAHHHKPEIMQQELAIHPHSEQNKSRSMESTLGYRKPTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELLKECTSEGHVKEVLQISSDGTTITVYYPNDGRGFPLADRPPLPTDNISRYSFDSLPEKYWRKYQYASRFIQLVRSKTPKITYFTRYAKCILMENSPGADFEVWFYDGAKIHKTEDVIHIIEKTGLSYTLKNENDFTSLKEEVKIYMDHANEGHRTCLALESVISEEEKRSRGSSFFPIIVGRKPGTTSSPKALSPPPVDPGYSKGEQASSSRLSANSAAFPTQTPVLSPSAVTVEGPGQTAATTGTSISSSLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILLMFSNPTPSFQ
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.  Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6.  Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors.  Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles.  Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1.  Phosphorylates CDC25C and CHEK2.  Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity).  Phosphorylates CEP131 and PCM1 which is essential for proper organization and integrity of centriolar satellites (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase Sak.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrioles throughout the cell cycle. Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity).