PharMolix/UniProtQA huggingface dataset:
Protein: CD5R2_MOUSE
Sequence: MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPAGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDGPDGGGTAKPLAVPVPTVPTTAATCEPPSGGSAAAPPPGSGGGKPPPPPPPAPQAAPPAPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASTGGPPSGSSASTTSSSSARDSCATGAKHWTMNLDR
What is the function of this protein?
Activator of CDK5/TPKII.
What are the official names of this protein?
Cyclin-dependent kinase 5 activator 2, CDK5 activator 2, Cyclin-dependent kinase 5 regulatory subunit 2, p39, p39I.
What is the protein family that this protein belongs to?
Belongs to the cyclin-dependent kinase 5 activator family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: DPH2_HUMAN
Sequence: MESMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPVAFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSPAFPQPVGSLSPEPMPLERFGRRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLGWAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARDARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILAPCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVALPPPESELWETPDVSLITGDLRPPPAWKSSNDHGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952).  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity).  Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, Diphthamide biosynthesis protein 2, Diphtheria toxin resistance protein 2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH2 subfamily.
Protein: ECP_MACNE
Sequence: MVPKLFTPQICLLLLLGLMGVEGSLHARPPQFTKAQWFAIQHINVNPPRCTIAMRVINNYQRRCKNQNTFLRTTFANTVNVCRNRSIRCPRNRTLHNCHRSSYRVPLLHCDLINPGAQNISTCRYADRPGRRFYVVACESRDPRDSPRYPVVPVHLDTII
What is the function of this protein?
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity.  Possesses a wide variety of biological activities.  Exhibits antibacterial activity (By similarity).
What are the official names of this protein?
Eosinophil cationic protein, ECP, Ribonuclease 3, RNase 3.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
Protein: O1052_MOUSE
Sequence: MATENCTVVTEFILLGLTDRAELKMMLFVLFLVIYAVTLLGNLGMILLIRITPKLHTPMYFFLSCLSFVDACYSSVIAPKMLISFLVVTETISFSACIMQHLFFGVLVTTEGFLLSVMAYDRYVAVVNPLLYTVSMSKQKCIMMVTGSVIGGTINSLTHTISLSKLSFCGPNIVGHFFCDIPSLLILSCSDTSMNEFLLLIFSGVIAIGTLLIVFISYLFIALAILRIRSASGRQKAFSTCASHLTAVTIFYGTLSFNYIQPSSQYSVEQEKVVSVFYTLVIPMLNPMIYSLRNKEVKEAAKRAIEMKSFSC
What is the function of this protein?
Potential odorant receptor.
What are the official names of this protein?
Olfactory receptor 1052, Olfactory receptor 172-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISPG_CHLAB
Sequence: MIHPPAQKQAARRYTHSVKIGNLYVGSDHSIKTQSMTTTPTADVDATVAQICALVEARCEIARVTVQGIKEAQACEHIKERLIALGIDVPLVADIHFFPQAAMHVADFVDKVRINPGNFVDKRNMFTGKIYTDKHYADSLLRLEEKFSPLVEKCKRLGKAMRIGVNHGSLSERVMQRYGDTIEGMVVSALEYIEVCEKLGYRDVVFSMKSSNPKVMVAAYRQLAKDLDARGWHYPLHLGVTEAGMGMDGIIKSSVGIGTLLTEGLGDTIRCSLTGCPTQEIPVCESLLKHTTTYLNLPRKNNPFALENSESFVNASKKITKTTPWGSVYGVFIKLNEDHMLNTPVEQLLEQLGIHPENGKKDFTTPDGVVVPKSFIGTSVLKKLEQHFIVFHHHEVPCLYDYNHEIWNQEEVLSSPFVHFHASPPFIHSTRDFFEKKQGEQQPVKLVFSKDLDDECEAAVAIATEFGALLLDGLGEAVILDLPNIPLSTVREIAFGTLQSAGVRLVKTEYISCPGCGRTLFDLPEVTKRIHERTQHLVGLKIAVMGCIVNGPGEMADADFGFVGSKTGMVDLYVKHTCVKAHIPMEQAEDELVLLLKEHGVWKDPE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: ABLM1_MOUSE
Sequence: MPSLLGLKCLGKLCSSEIGKVPSPERASLRNSHRRLLIEDLSVPETPDPAHRRRGTVIHLVYLYSAGCGPPELRFSSYDPSVAHPQDPHHSSEKPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGDYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKEASCSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGSPYCEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEKLRPPNIPRSSSDFFYPKSLIRRTGRSPALQLLSPPCLTNSNKNPRQPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYEDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPELLSPGVHRWSPLRTSSFSSTHSDSRPNPPFRHHFLPHVKGNEPSSGRNSPLPYRPDSRPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHAALAAQSKASEDIIKFSKFPAAQAPDPNEIPKIETDHWPGPPSLAAVGTDPRRRSSGREEDEEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKESRERASLASRYDSPLHSASHAPSSKTSSLPGYGKNGLHRPVSTDFAQYNSYGDISGGVRDYQTLPDGHMPAVRMDRGVSMPNMLEPKIFPYEMLMVTNRGRNKILRDVDRTRLERHLAPEVFWEIFGMSIQEFDKLPLWRRNDMKKKAKLF
What is the function of this protein?
May act as scaffold protein (By similarity).  May play a role in the development of the retina.  Has been suggested to play a role in axon guidance.
What are the official names of this protein?
Actin-binding LIM protein 1, abLIM-1, Actin-binding LIM protein family member 1.
Protein: Y2382_VIBCH
Sequence: MHKSSNFSGLNLVKSAPICLLDIFHRCVDSETALDTSLLYLIDMFGTAVFAVSGVLLAGRLKMDPFGVMVLASVTAIGGGTIRDMALGATPVFWIKDTNYLWVIMITCALTMLLVRRPKRLAWWILPVCDAIGLAVFVGIGVEKALIYQDSALIAIIMGVITGCGGGIIRDVLAREIPMVLRSEVYATACIIGGIFHTTALAMGYSSSTALLSGVFSTLLIRLGAIRWHLSLPTFALTK
What are the official names of this protein?
UPF0126 membrane protein VC_2382.
What is the protein family that this protein belongs to?
Belongs to the UPF0126 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MRAY_BURMS
Sequence: MLLALAQWLQGDASFLRLFTYLTFRAVMATITALVIGLVCGPWVIRKLTQMKVGQAVRKDGPQTHLVKSGTPTMGGVLILIGIAVATLLWGDLTNRFIWIVMLVTFGFGVIGWVDDYRKVVYKDPRGMSSREKYFWQSVIGLFAAVYLAFSVSEANNVRVFDLFMAWVRSGLSMGLPARADLMLPFLKSISYPLGVWGFIALTYFVIVGASNAVNLTDGLDGLVIMPVVLVGASLGVFAYVMGSAVYSKYLLFPHIPGAGELLIFCSAMGGAGLAFLWYNTHPAQVFMGDVGALALGGALGTVAVIVRQEIVLFIMGGIFVAETLSVMLQVTWFKYTKKRYGEGRRIFKMAPLHHHFELSGWKETQVVVRFWIITLMLCLFGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: STN1_BOVIN
Sequence: MESNSSQCEDETPSLLWGLDPVFLAFAKLYIRDILDLKESGQVQGVFFYNGHPIKQVDILGTVIGVREKDAFYSYGVDDSTGVINCICWKRLNNTKSSSATATPSARELSLTSQLKKLQETIAQRAKLEIGDIIRVRGHIRMFRGEREIHATTYYKVDDPVCNVQIARMLELPAIYRKVYDQPFHSPALKEDEALSNPGTLDLDSLTCLLSEKAKEFLVENRVQSFYQQELETVESLLSLANQPVIHSACSGQMGFKNDTTSRAIHSIFRNAVKLLQEEGLVFQKDGGFDNLFYVTREDKELHRKIHRIIQEECQKPNHVEKGCHFLHILACARLSLSPGLSEPVLQQVLQLLEDQSDIVSTTEKYYTAF
What is the function of this protein?
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex.  The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves.  Initially the CST complex has been proposed to protect telomeres from DNA degradation.  However, the CST complex has been shown to be involved in several aspects of telomere replication.  The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity.  The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha.  The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins.  Required for efficicient replication of the duplex region of the telomere.  Promotes efficient replication of lagging-strand telomeres.  Promotes general replication start following replication-fork stalling implicating new origin firing.  May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity).
What are the official names of this protein?
CST complex subunit STN1, Oligonucleotide/oligosaccharide-binding fold-containing protein 1, Suppressor of cdc thirteen homolog.
What is the protein family that this protein belongs to?
Belongs to the STN1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: NEMF_DROME
Sequence: MKTRFNTFDIICGVAELQKLVGWRVNQIYDVDNKTYLFRMQGTGAVEKVTLLIESGTRFHTTRFEWPKNMAPSGFSMKLRKHLKNKRLEKVQQMGSDRIVDFQFGTGDAAYHVILELYDRGNVILTDYELTTLYILRPHTEGENLRFAMREKYPVERAKQPTKELELEALVKLLENARNGDYLRQILTPNLDCGPAVIEHVLLSHGLDNHVIKKETTEETPEAEDKPEKGGKKQRKKQQNTKLEQKPFDMVNDLPILQQAVKDAQELIAEGNSGKSKGYIIQVKEEKPTENGTVEFFFRNIEFHPYLFIQFKNFEKATFESFMEAVDEFYSTQESQKIDMKTLQQEREALKKLSNVKNDHAKRLEELTKVQDVDRKKAELITSNQSLVDNAIRAVQSAIASQLSWPDIHELVKEAQANGDAVASSIKQLKLETNHISLMLSDPYDNDEDDDLKDPEVTVVDVDLALSAWANARRYYDMKRSAAQKEKKTVDASQKALKSAERKTQQTLKEVRTISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQNELIVKRYMRPKDIYVHAEIQGASSVIIQNPTGEEIPPKTLLEAGSMAISYSVAWDAKVVTNSYWVTSDQVSKTAPTGEYLATGSFMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDDQIDPNVKENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRSDSVNPEIEETKESEVVLDKILKKTDDEETTIILAGPSRKKQVSAKKTKEDKARAKQEAAKQEVPPVSSEPKNPSQVKRGQKGKLKKMKQKYKDQDDEEREIRMMILKSSGKEKPQASADKVVEKSESTKEYVKPEKSAAPKNPVELDDADEVPVGGDVDVLNSLTGQPHEGDELLFAIPVVAPYQALQNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEESLARNIPGKVKLSAPQLQKYHK
What is the function of this protein?
As part of the ribosome quality control complex (RQC), a ribosome-associated complex, mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation.  Thereby, frees ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (By similarity).  Responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety (PubMed:31378462).  Binds to Ala- and Thr-tRNAs and, to a lesser extent, Ser-tRNA (PubMed:31378462).  On mitochondrial surface, plays a role in mitochondrial-stress induced translational termination impairment and protein carboxyl terminal extension (MISTERMINATE) (PubMed:31378462).  Important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity).  Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins (PubMed:16103875).  Plays a role in the regulation of G1-to-S cell cycle transition (PubMed:30231800).  Regulates S phase checkpoint by antagonizing E2F1 activity (PubMed:30231800).  Together with hid and tefu/ATM, plays a role in DNA damage-induced apoptosis through both p53-dependent and -independent activity (PubMed:22964637).  Plays an essential role in the regulation of mitochondrial structure and redox state in enterocytes which is essential for the control of intestinal stem cells proliferation and intestinal homeostasis (PubMed:33057338).
What are the official names of this protein?
Ribosome quality control complex subunit NEMF homolog, Protein Caliban.
What is the protein family that this protein belongs to?
Belongs to the NEMF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HRCA_CHLTA
Sequence: MENRIEMSQLRASKKDSKISYVLLMATKLYLESSQPVGSKLLKETYCSDLSSATIRNYFAQLETDGFLRKNHISGGRIPTDLAFRYYVDHNVPFLEQEEILAIQQKLTELPEYSKNIVKDLQKASEVLSDILQLPVCFSSPRFESDSVINIQLVAIDDQRVVFVLSTEFGQVFTDVLWLPEQLPENSLKRIEGFLQNYLRKQPSDGLLSQKEEDLGMVLYNEVVVRYLTRYCHFSEEDLYQTGLSRLLKYGTFKEPETLAQGLAFFENRKHMCQLLNTYLHKETPTAFIGRELADIVGNTDPSCAVITIPYYMDHTPLGAFGVLGPMNLPYQQVFGTLSLFTERLKVILTQSFYKFKLSFRRPCPTDPRCSQRPAELTRSSSIKLLPAKELS
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: PSBB_PSINU
Sequence: MGLPWYRVHTVVLNDPGRLIAVHLMHTALVSGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRIGITKSWGGWSITGDTVSDAGIWSFEGVAAAHITLSGLLFLSAIWHWVYWDLDLFRDERTGKPSLDLPKIFGIHLFLSGVLCFGFGAFHITGLFGPGIWISDPYGLTGKVQPVDPAWGAEGFDPFIPGGIASHHIAAGILGILAGLFHLSVRPPQRLYKALRMGNVETVLSSSIAAVFFAAFVVSGTMWYGSATTPIELFGPTRYQWDQGYFQQEIDRRIRASRAEGLSLSEAWSRIPEKLAFYDYIGNNPAKGGLFRAGAMDNGDGIAIGWLGHAAFKDKEGHELFVRRMPTFFETFPVVLVDEEGIVRADAPFRRAESKYSVEQVGVTVEFYGGELNGVGFNDPSTVKKYARRAQLGEIFEFDRATLKSDGVFRSSPRGWFTFGHATFALIFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGAFQKLGDPTTERQGI
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL34_CHLMU
Sequence: MKRTYQPSKRKRTNSVGFRARMATKSGRNLLNRRRRHGRHSLIDL
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: UVRC_RICPU
Sequence: MTLEITGSELIKSKLIDAPERSGVYRMFDVNKQVLYVGKAKNLKKRLTNYIKSNLDNKTLRMIANTCFLEYSITNSEVEALLLEAQLIKKFQPKFNILLKDCKSFPFIKLRLDHDFPQLLKYRGKTLSDGKFFGPFASSAEVNTTLTELQKIFKLRSCTDNYFNSRTRPCLQYEIKRCYAPCVGKINKEDYRDLVTQVKDFLQGRTKELQENLSRKMEELSSQMRFEEAAEIRDRIKALSYVQLKAGVSDVVKDADIIAIVEKNGHYCVEVFLYRAGQACGNIPYFPTSTENSTKEEVLEYFLLQFYQKQHVPAAIIINHEINDKENVIEAIKKINNILQLNITVPNKGGKAKLVQNAETNALFSLEQYLKKFAKNQEIMFEIKELFGLSEIPERIEIYDNSHIQGKFAVGVMVVAGKVGFDKKEYRVFNVHAPSLVCHSRESGDPKRLMDSCFRGNGIKNCGGDIKGDDYEMLRQVLTRRLTRLRQEPHKLPSLMIIDGGKGHLGVVKEVMDKFEMNIPFVCMSKGVDRNTGFEQFHVIGKEVFTLDKNLPVMKYLQILRDEAHNFAIKNHRLGRSRAIKISRLDDIEGVGETRKKALLHYFGSYKAVCDATIYELAKVNGINKLLAEMIFNVLHRKN
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTH_RHIME
Sequence: MTVILRPGSVPLSDLETIYWTGAPARLDAAFDAGIAKAAARIAEIVAGNAPVYGINTGFGKLASIKIDSSDVATLQRNLILSHCCGVGQPLTEDIVRLIMALKLISLGRGASGVRLELVRLIEAMLDKGVIPLIPEKGSVGASGDLAPLAHMAAVMMGHGEAFFAGERMKGDAALKAAGLSPVTLAAKEGLALINGTQVSTALALAGLFRAHRAGQAALITGALSTDAAMGSSAPFHPDIHTLRGHKGQIDTAAALRQLLTGSPIRQSHIEGDERVQDPYCIRCQPQVDGACLDLLRSVAATLTIEANAVTDNPLVLSDNSVVSGGNFHAEPVAFAADQIALAVCEIGAISQRRIALLVDPALSYGLPAFLAKKPGLNSGLMIAEVTSAALMSENKQLSHPASVDSTPTSANQEDHVSMACHGARRLLQMTENLFSIIGIEALAAVQGIEFRAPLTTSPELQKAAAAVRGVSSSIEEDRYMADDLKAAGDLVASGRLAAAVSAGILPKLEN
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYCB_ECOL6
Sequence: MNRFVIADSTLCIGCHTCEAACSETHRQHGLQSMPRLRVMLNEKESAPQLCHHCEDAPCAVVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPLDIPANANTPKAPPAPPAPARVSTLLDWVPGIRAIAVKCDLCSFDEQGPACVRMCPTKALHLVDNTDIARVSKRKRELTFNTDFGDLTLFQQAQSGEAK
What is the function of this protein?
Probable electron transfer protein for hydrogenase 3.
What are the official names of this protein?
Formate hydrogenlyase subunit 2, FHL subunit 2, Hydrogenase-3 component B.
Protein: RS6_FLAJ1
Sequence: MNHYETVFILNPVLSEVQVKETVTKFEEFLTSRGAEMVSKEDWGLKKMAYEIQNKKSGFYHLFEFKVAGEVLIAFETEFRRDERVMRFLTVSLDKHAISWAERRRAKLKSTKA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: AP3S2_MOUSE
Sequence: MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV
What is the function of this protein?
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated.  The complex is associated with the Golgi region as well as more peripheral structures.  It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.  In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
What are the official names of this protein?
AP-3 complex subunit sigma-2, AP-3 complex subunit sigma-3B, Adaptor-related protein complex 3 subunit sigma-2, Sigma-3B-adaptin, Sigma3B-adaptin, Sigma-adaptin 3b.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: RSMG_SHEB9
Sequence: MLSAQLEAYLAEINLPATAEQKKQLIDFVGMLNKWNKAYNLTSVRDPEAMLIRHIMDSLVVSKHLQGERFIDVGTGPGLPGIPLAIMNPDKQFVLLDSLGKRIRFQKQVSFELGIHNISSVESRVEAYQPEQKFDGVLSRAFASIQDMLTWCHHLPAEHGQFYALKGQLNDEEMQHIPSGFAVKEVIELKVPKLDEQRHLLKIIKE
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POLS2_MOUSE
Sequence: MSPHLFLPVVVLVVSPTPGAFQDSAVSPTQGEFEDLDCGRPEPSSRIVGGSDAHPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFVTNGTLEPADEWSVLLGVHSQDGPLEGAHMRSVATILVPDNYSRVELGADLALLRLASPAKLGPSVKPVCLPRASHLFAHGTACWATGWGDVQESDPLPVPWVLQEVELKLLGETACQCLYSRPGPFNLTLQLLPGMLCAGYPEGRRDTCQGDSGGPLVCEDGGRWFLAGITSFGFGCGRRNRPGVFTAVAHYESWIREHVMGSEPGPAFPSQLQKPPSEPWEPREENCTFAQPECGKATRPGTWPWEAQVMVPGSTPCYGALVSDSWVLAPASCFLDSLHDFETWRVLLPSRPEEKRVVRLVAHENASRNFASDLALLQLRTRVNLTAAPSAVCLPHREHYFLPGSRCRLARWGHGEPAPRSSAQLEAQLLNSWWCHCLYGRQGESVPPPGDPPHLLCPAYQEEEEAGACWVDSGWSLLCREEGTWFLAGYRTLSNGCLRPRAFSPMQTHGLWISHVTQGAYLEDQLTWDWGPEGEETEKQTCPPHTEHGACGLRPQSTPAGVLWPWLTEVHVTGDRVCTGILVAPGWVLAATHCILRLGSSTVPYIDVYLGLAGVSSLPQGHQVSRSVVSIRLPRHSGLRPPLALLELNSRVEPSPSALPICLHPEGVPPGASCWVLGWKDPQNRVPVAAAVSILTPRLCHCLYQGALTPGTFCVFYTEEQEDRCEMTSAPPLLCQTEGGPWVLVGMAVRGSRELFAAIGPEATWISQTVGEAHFLHLGGSSYWSPEGSDPCPQDLAGSASSPKVAALPLLLALLIPR
What is the function of this protein?
Serine protease.  Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC.  Has a preference for substrates with an Arg instead of a Lys residue in position P1 (By similarity).
What are the official names of this protein?
Polyserase-2, Polyserine protease 2, Serine protease 36.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Note=Not attached to membranes.
Protein: GLK_PSYIN
Sequence: MKQVSLVGDVGGTNARLALCDLETGSISHSLTYSGLDYPSLEAVVRVYLDQQSLRIEQACIGIACPIDGDQVSMTNHSWAFSIKQMQENLGLKKLTIINDFTAVSMAIPVLGADDKVQLGGGLARSGKPIAVYGAGTGLGVAHLVQSCDRWLSLPGEGGHVDMASCTEQEDALIQQLRLELGHVSAERLLSGPGLVNIYKGLVTSDHRVPEILTPKQISDRALSGECHDCHRALSLFCVLMGRFAGNLALNLGTFGGVYIAGGLVPRFLEFFKASGFREAFADKGRFKEHLEAIPVYVITHSQPGLLGAGAYLRQSLGITL
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAS10_THEON
Sequence: MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEYELLSLFSEFHHKGHMKNDELMIRRIKELSPERFGLTMEDVLNALWIVYEADNLASGEREEGQPQASRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKRLWEELSKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRAGCTAEDVRSGRCRKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGKNLFAEARKRLKHKLTVRKLKRFGEIKGLFEHGHTERLAECPVCGRELPEGKLEPSASDPETKVCPTCNRLVSLGGNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGGRPVGEQILVKNTLNPGEIPESAQFVPYFVADYFKKDPKGGVATFEELSMASTGTRRLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIEGKFGYIIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVFVVGRSRPLDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGLSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLMAVRR
What is the function of this protein?
When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP.  cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids.
What are the official names of this protein?
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ssDNase Cas10, Cyclic oligoadenylate synthase, ToCsm1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Cas10/Csm1 family.