PharMolix/UniProtQA huggingface dataset:
Protein: PROA_SHEON
Sequence: MSQINQAQYLQQLGHNAKQASYALANLTASQKADLLDAIADALTENTLAILAANAKDVAAAKAEGLNDAMIDRLLLNESRLAGIIGDISDVVRLADPVGEEFGSRVLDNGLRLTRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLESNKLISEVIRGAIASQGLPVDAVQLIDSSDRALVTGLLKLDQYVDMIVPRGGQALQRLCAEQATIPVILGGIGICHLYVDKAANLERALEVIANAKVQRPTVCNALDTLLVDKTIAANFVPQIVEYLHCLGVRFSVCEQSHALLDGLGFDIELATEQSFATEWLSLTLGIKVVSDIDAAIAHIRRHSSGHSEAILTDDIHAATHFMNEVNSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWLAWGDYTSRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAGP_METFK
Sequence: MNIRHGIIAMSSTMLVPLAAEAACNTDYSWIDKSCERISDTWKNGDHDLYIPLWTHHLRFAYDNDKIDSFREFTWGLGYGRSRYNAAGNWEGVYLMAFSDSHSNVQPMLGYGHQWMMGPRSGLHAGVGYTAFLTSRADIYKNIPIPGVLPIASLNYRQYSVNTSYVPGGRGNGNILFFWSRVGF
What is the function of this protein?
Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.
What are the official names of this protein?
Lipid A acyltransferase PagP, Lipid A acylation protein.
What is the protein family that this protein belongs to?
Belongs to the lipid A palmitoyltransferase family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: HUTU_BACHK
Sequence: MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYNAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGSLKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNAAEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLTMQAKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGASWVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAA_SALPC
Sequence: MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPGGVTNNGFLTVDEIRRVTRAFASLGTEKVRLTGGEPSLRRDFTDIIAAVGENDAIRQIAVTTNGYRLARDAANWREAGLTGVNVSVDSLDARQFHAITGQDKFRQVMAGIDAAFDAGFEKVKVNTVLMRDVNHYQLDTFLAWIQPRPIQLRFIELMETGEGSDLFRKHHISGQVLRDELIKRGWIHQLRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSVGKLHLCLFGDGGVSLRDLLQDDAQQYALEERISDALREKKQTHFLHQSNTGITQNLSYIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: PRMA_CYAP4
Sequence: MVSSWWEIQVVGDAALEEGISWRLQSFGCQGTASQKQNHDCHMTGYLPQKQVNHLDLAALSLWLAQDAIALGFLPPTTRWKLINEEDWATSWQQYWHPQEVGDRLLIYPAWLDLPEHCERLLLRLDPGVAFGTGTHPTTQLCLEALEMHLDQTFGPVEQVTVADIGCGTGILSIAALRLGAKQAFAVDLDPLAVESADRSRDLNEIPPEQMIVQQGSVEQVPHPVQGIVCNILAETIIDLIPTLATISQPHTWAAFSGILVTQAKSVVDALEQQGWQVGSLWQRQDWCCINAHRL
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_SPHAL
Sequence: MKIKVQTLDGKAGADIDLNDDVFGLDARADILHRVVAWQLEKRRGPARAARERSDVARTGKKFGRQKGGGTARHGDRRAPIFIGGGKAHGPRARTFGHSLNKKIRTLGLKMALSDKAKGGKLVVIDTLELKDAKTKALAGKLGKLDLGKRALFIDGDAVHESFAMASANLIGVDALPAIGANVYDIVRADTLVLTRAAVEKLEARCNG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MSRQ_ECO55
Sequence: MRLTAKQVTWLKVCLHLAGLLPFLWLVWAINHGGLGADPVKDIQHFTGRTALKFLLATLLITPLARYAKQPLLIRTRRLLGLWCFAWATLHLTSYALLELGVNNLALLGKELITRPYLTLGIISWVILLALAFTSTQAMQRKLGKHWQQLHNFVYLVAILAPIHYLWSVKIISPQPLIYAGLAVLLLALRYKKLLSLFNRLRKQVHNKLSV
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TREX1_MOUSE
Sequence: MGSQTLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAALKALEQASSPSGNGSRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQWVDEHARPFSTVKPMYGTPATTGTTNLRPHAATATTPLATANGSPSNGRSRRPKSPPPEKVPEAPSQEGLLAPLSLLTLLTLAIATLYGLFLASPGQ
What is the function of this protein?
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini (PubMed:10391904, PubMed:11279105, PubMed:15254239, PubMed:17293595, PubMed:17355961, PubMed:18780819).  Prevents cell-intrinsic initiation of autoimmunity (PubMed:18724932, PubMed:24218451).  Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements (PubMed:18724932).  Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation (By similarity).  Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation (By similarity).  Unless degraded, these DNA fragments accumulate in the cytosol and activate the cGAS-STING innate immune signaling, leading to the production of type I interferon (PubMed:18724932).  Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates (PubMed:18045533).  Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light (PubMed:23993650).  During GZMA-mediated cell death, contributes to DNA damage in concert with NME1 (By similarity).  NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity).
What are the official names of this protein?
Three-prime repair exonuclease 1, 3'-5' exonuclease TREX1.
What is the protein family that this protein belongs to?
Belongs to the exonuclease superfamily. TREX family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Retained in the cytoplasm through the C-terminal region (PubMed:18045533). Localization to the endoplasmic reticulum membrane is required to direct TREX1 to ruptured micronuclei (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci (PubMed:18045533). Translocation to the nucleus also occurs during GZMA-mediated cell death (PubMed:18045533).
Protein: IXOL_IXOPA
Sequence: MNAAFIAALFILGALTLDAMAYSPTCEGKPCANNTDCKGSNLCQCRPPRGDDWRNFCSEY
What is the function of this protein?
Tick salivary platelet aggregation inhibitor that plays an important part in the anti-hemostatic strategy of ticks.  Inhibits platelet aggregation induced by ADP, thrombin and thromboxane A2 (TXA2).  Blocks platelet adhesion to soluble collagen (most probably through the binding to alpha-2/beta-1 integrin (ITGA2/ITGB1)) and binds to purified glycoprotein IIb/IIIa (ITGA2B/ITGB3) in a dose-dependent manner.  In vivo, reduces thrombus weight effectively in a rat arteriovenous shunt model and inhibits thrombosis in a carrageenan-induced mouse tail thrombosis model.
What are the official names of this protein?
Ixodegrin-Ip, Platelet aggregation inhibitor, PAI, Tick anti-thrombosis peptide.
What is the protein family that this protein belongs to?
Belongs to the ixodegrin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GRM5_RAT
Sequence: MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTENRGPGAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEESFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAATPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQGATGVSPAQETPTGAESAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL
What is the function of this protein?
G-protein coupled receptor for glutamate.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.  Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
What are the official names of this protein?
Metabotropic glutamate receptor 5, mGluR5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 5H1AA_TAKRU
Sequence: MDLRATSSNDSNATSGYSDTAAVDWDEGENATGSGSLPDPELSYQIITSLFLGALILCSIFGNSCVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQDICDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISVTWLIGFSISIPPMLGWRSAEDRANPDACIISQDPGYTIYSTFGAFYIPLILMLVLYGRIFKAARFRIRKTVKKTEKAKASDMCLTLSPAVFHKRANGDAVSAEWKRGYKFKPSSPCANGAVRHGEEMESLEIIEVNSNSKTHLPLPNTPQSSSHENINEKTTGTRRKIALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCAENCYMPEWLGAVINWLGYSNSLLNPIIYAYFNKDFQSAFKKILRCKFHRH
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores.  Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism.  Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 1A-alpha, 5-HT-1A-alpha, 5-HT1A-alpha, F1A, Serotonin receptor 1A-alpha.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL11_ECOSE
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSIEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKISRAQLQEIAQTKAADMTGADIEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: LIP4_CANAL
Sequence: MLFLLFLLVAPIYAGLILPTKPSNDPFYNAPAGFEKAAVGEILQSRKTPKPITGVFVPVKIQNSWQLLVRSEDSFGNPNVIVTTVMEPFNADPSKLASYQVFEDSAKADCAPSYALQFGSDVTTIATQVETYLLAPLLDQGYYVVSPDYEGPKSTFTVGKQSGQAVLNSIRAALKSGKITNLAEDAKVVMWGYSGGSLASGWAAALQPNYAPELGGNLLGAALGGFVTNITATAEATDGTVFAGIMANALGGVANEYPEFKQILQNDTDKQSVFDQFDNHCLADGVINYIGKHFLSGTNKIFKSGWNILKNPTISKIVEDNGLVYQKQLVPKIPILIYHGAIDQIVPIVNVKKTYQNWCDAGIASLEFSEDATNGHITETIVGAPVALTWIINRFNGKQTVSGCQHVKRTSNFEYPNIPPSILNYFKAALNILIQKGLGPDIQKDQVNPDGLKKIPILV
What are the official names of this protein?
Lipase 4.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL2_CUTAK
Sequence: MGIRKYKPTTPGRRGSSVSDFVELTRSTPEKSLLVAKPKTGGRNNTGRITTRHIGGGHKQAYRIIDFKRYDKDGVPAKVAHIEYDPNRTARIALLHYADGEKRYIIAPDGVGQGTVVVSGPEADIKPGNNLPLRNIPVGTTVHAVELRPGGGAKMGRSAGASVQLVAREGKYATVRLPSGEMRMVDIRCRATIGEVGNAEQININWGKAGRNRWKGIRPTVRGVVMNPIDHPHGGGEGRTSGGRHPVSPWGKPEGRTRNKKKASSRLIVRRRKSGKKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: MRAY_ARATH
Sequence: MRCSLLTPTSYRFHYPNPFRSLESIPPLSNSRYRIESGSPSSFKFSAPSLQRHSSVSVKAFDDDTFDFYTGDIFAATYAISSSEGEESDGDYALNVVTETTAQKLGKFPRGRKKHRIRYGINLGLLAFLSLLLLLMDSFAWKIVRLPLPPYFLSMPFFTSAILVTLAGYIFVPLLDRLRVHEPIRTLGPVPHNRRPTIPTMGGLFFVPIGVVVAIALNKVSSIEVLGAAAATVAFAAIGLIDDSLSLYSENNNGLSAKIQLLLEAAVGTCFAFWLETASLSSPYGMKMLVPLPSPLGLVFLGKLYLLLTSFYFVSMGNLVKATDGLDGLAGGIAALCFVAMAIAVLPICSDLSVFGASMAGACFGFLLHNRYRASVSMGDTGSLALGGALAAMAACSGMFFPLFISSGVAVLEASSVIIQVVYYSTTKRLKGKGRRIFKTIPFHHHLRLNGLKEPMIVTMAYVISSLLSLSAAYIGLISA
What is the function of this protein?
May be involved in glycosylation events.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase homolog, Translocase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IF2_FRAP2
Sequence: MAEITVGQLAQQTNKEVSTLLKQLKSFGIEKSSEKDTLTPEEMKTLLDKINSAKNTVTRKKVTSLKLDGKHKINVSVKKKRRVAKKVEEQSPAKVEESIVEKPQAAVDVKDNKAVESVERNSVNLVQPQQEKPVTKPVIKDNGFKITAMPEVKIQENNSQDEEKSSEDKSTESKNNKKKSPKKVFTESGNNTNTKYKREEEEKKSKAKKASGKGFKKANPRQLSQLAGDLESFDEFGSKKGKLKAPKVKKQEFTMPVESAVKTIEIREGITVSDLANRMAVKGAEIVKVLFNMGVMATINQSLDQDTAVLIVEEMGHKYTLHNENALEEAVTTVDRSLHKKISRAPVVTIMGHVDHGKTSLLDYIRKARVVAGEAGGITQHIGAYSVKTSKGAITFLDTPGHEAFTSMRARGAKSTDIVILVVAADDGVMPQTEEAIQHAKAAGVPIVVAVNKIDKPDADPDKVVGELAQRNVIPESWGGDVMFANVSAKTGEGVAELLDAVLLQSEVLELEAFAEGLAEGVVIESRLEKGRGPVATVLVQNGSLKQGDNILCGTEYGRVRAMHDDLGKQIKVAGPATPVEILGLSGVPAAGDDMVVIENEKKAKELAAQRSQRQKEAKIAQEQSLKLSNMFSNMGKEGEQQTLKIILKGDVQGSVEAIRESLLKLSTDEVKVDIIASGIGAITSSDVTLAVASTAVIIGFNVRADSAAKKLAEVDGVELRYYNIIYDLIDDVKKAMTGLLSPDMKEQIIGIAEVREVYRSSKFGSIAGCMVVEGAVKRTNPIRVLRDNVVIYEGTLESLKRFKDDASEVKKGMECGIGVKNYNDVREGDQIEVFEVIEVAKEL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIE_ECO81
Sequence: MSAIQGIEGVISQLQATAMSARAQDSLPQPTISFAGQLHAALDRISDTQTAARTQAEKFTLGEPGVALNDVMTDMQKASVSMQMGIQVRNKLVAAYQEVMSMQV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: LEUD_BACCN
Sequence: MMEPFRTHKGTVAVLMNDNIDTDQIIPKQYLKRIERTGFGKFLFDEWRYEEDRKENPHFPLNDPERKGASILITGENFGCGSSREHAPWALADYGFRVIIAGGFADIFYMNCMKNGMLPIVMDKETREKLAAIEARTIVEVDLENEVIMTTQHQFHFSIEKMWREKLLKGLDEIEITMQYEEYIQEYEEKVVH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RSMH_COLP3
Sequence: MELDTTHISVLLNEAVDGLAITDDGCYIDCTFGRGGHSSVILSKLSDNGRLIAIDRDPTAITAAEKFKDDKRFLIEHQGFAALAEIAEKHELTGKVDGILLDLGVSSPQLDEAERGFSFMKDGPLDMRMDTSKGQTAAEWLAVADVEDITWVLRTFGEEKHAWRIANAIVDTREETPLTRTSQLAKLIKTTAPQREIKKHPATRSFQAIRMYINSELDQIEKALVASLDVLAEGGRLVVISFHSLEDRLVKQFMKKHSQGKKVPRGLPISEIELNKGKKLSLVGRRLKPSQTEVEENVRSRSSVLRVAERLERNTD
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTAJ_PESFW
Sequence: MAASTAAQVQLSEEALGLARIFENPKGSLEAASKLLQKNHDEFHVFWRDVGGHNHIPHSVLSILALGGGPAELQRAWDDGVAIQRPTPPLDEDVVKKLENPAEFRARIGSIPNYTNFLHFFRNQMDKKGWQAVVSEYAFSRTPLAETIFAQLFEGAYHPFIHIGFGIEFNLPSIIAEGLAQAATHDSAGIEGFFLEAERQAAQSKGPGKSLVQLLDEVRTTEKIKTAARLPDGPVRVRDGVIGRAGAEIAALASQFRVPADQLSRGAAESINISAYTAGAAQRAGKARKIDFFHMHNTTSSLFLTVFLNQPWISTEDKVRIVEWKGRLDLVWYAACSAPDLNVDHVIGYKPAQSAGWGWKELYEAINVAHDDGHLAKIVRALKNGEEVSRPFESGEGAEAFPIKGDSWLKLAQMSYDTTLDLPDDDKWIWGAGFLPLWNKVPSL
What is the function of this protein?
Baeyer-Villiger oxidase; part of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes (PubMed:24302702).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS ptaA (PubMed:24302702).  As the ptaA protein is TE/CLC domain-deficient, hydrolysis and Claisen cyclization of the polyketide could be catalyzed by ptaB containing a beta-lactamase domain (PubMed:24302702).  The ptaB protein might hydrolyze the thioester bond between the ACP of ptaA and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrated to form endocrocin anthrone (PubMed:24302702).  Endocrocin anthrone is then converted to endocrocin, catalyzed by the anthrone oxygenase ptaC (PubMed:24302702).  Spontaneous decarboxylation of endocrocin occurs to generate emodin (PubMed:24302702).  An O-methyltransferase (ptaH or ptaI) could methylate emodin to form physcion (PubMed:24302702).  PtaJ could then catalyze the oxidative cleavage of physcion, and rotation of the intermediate could then afford desmethylisosulochrin (PubMed:24302702).  PtaF, a putative NADH-dependent oxidoreductase, might also participate in the oxidative cleavage step (PubMed:24302702).  Desmethylisosulochrin is then transformed by another O-methyltransferase (ptaH or ptaI) to form isosulochrin (PubMed:24302702).  Chlorination of isosulochrin by ptaM in the cyclohexadienone B ring then produces chloroisosulochrin (PubMed:24302702).  PtaE is responsible for the oxidative coupling reactions of both benzophenones isosulouchrin and chloroisosulouchrin to RES-1214-1 and pestheic acid respectively, regardless of chlorination.
What are the official names of this protein?
Baeyer-Villiger oxidase ptaJ, Pestheic acid biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the questin oxidase family.
Protein: ARNE_SALTI
Sequence: MIGIVLVLASLLSVGGQLCQKQATRPLTTGGRRRHLMLWLGLALICMGAAMVLWLLVLQTLPVGIAYPMLSLNFVWVTLAAWKIWHEQVLPRHWLGVALIISGIIILGSAA
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE, L-Ara4N-phosphoundecaprenol flippase subunit ArnE, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE.
What is the protein family that this protein belongs to?
Belongs to the ArnE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL3_THEM4
Sequence: MKMIIGRKLGMTRVFVGDKVVPVTVIKAGPCFVVQKKTIETDGYNAVQLGFEEAKKVNKPMEGVFKKAGVNPLKVLKEFRVEDPDKFEVGQEIKVDIFSEGDKIDITGWSKGRGFAGAMKRWGFRGGPKSHGAKFHRELGSVGQHSEPARIFKGKKMPGQYGNERVTILNSEIVKIDVENNLIAVKGGVPGARGGLVLIKSAKRG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: CALM_EMENI
Sequence: MADSLTEEQVSEYKEAFSLFDKDGDGQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.