PharMolix/UniProtQA huggingface dataset:
Protein: ANDE_EMEVA
Sequence: MEQQSLKVVIVGGSIAGLTLAHCLHRANIDHVVLEKRAEIAPQEGASIGIWPNGARMLEQLGLYGELEKLTEPLNLMHIAFPDGFSFEDLLPTTINQRFGYPIIFLDRQKFLETLYRKYPDKSKIVTNTRVAEVQSSEKCARVITEDGTMYEGDIVVGADGVHSLVRREMWKLGDSKQPGSVPSREKTGMTVEYSCVYGISSPIVGLRAGESVNSYMDGMTVLTFHGKGGRVYWFLIQKLHQKYTYPNTPRYTVEDAERLCTDHRDTTIWKDIRIGHLWDNREVVSMTALEENLFAKWHFHRIGLMGDSIHKMTPNIGQGANSAIEDAAVFSSLLVHMMTSEGPGRPSSARIQRLLHDYQACRYERAEMIYHRSRFGARFQSRDDAVKLIVGRYVVPRIRNRLANISSMLIANGEIIQYLPFPKRSGPGWEKFRNKGEWMPYTPFALFSAILLVQHVVPLLGLTSPLLLAS
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of anditomin, a fungal meroterpenoid (PubMed:25216349).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase andM (PubMed:25216349).  DMOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHDMP) by the cytochrome P450 monooxygenase andK, which is further prenylated by the prenyltransferase andD to yield farnesyl-DHDMP (PubMed:25216349).  Further epoxidation by the FAD-dependent monooxygenase andE leads to epoxyfarnesyl-DHDMP (PubMed:25216349).  The next step involves the terpene cyclase andB that converts epoxyfarnesyl-DHDMP into preandiloid A through opening of the epoxide ring followed by the cyclization of the farnesyl moiety (PubMed:25216349).  Preandiloid A is in turn oxidized at the C-3 hydroxyl group to yield preandiloid B by the dehydrogenase andC (PubMed:25216349).  The dioxygenase andA is solely responsible for the dehydrogenation of preandiloid B leading to the enone preandiloid C, as well as for the intriguing structural rearrangement to generate the bicyclo[2. 2. 2]octane core, transforming preandiloid C into andiconin (PubMed:25216349).  FAD-binding monooxygenase andJ then produces andilesin D which is reduced by dehydrogenase andI to yield andilesin A (PubMed:25216349).  Action of acetyltransferase andG followed by a spontaneous acetate elimination leads then to andilesin B, which is in turn substrate of the short chain dehydrogenase andH to yield andilesin C (PubMed:25216349).  Finally, the dioxygenase andF catalyzes the transformation of andilesin C to anditomin (PubMed:25216349).
What are the official names of this protein?
FAD-dependent monooxygenase andE, Anditomin synthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: 5DNU_VIBPA
Sequence: MKESHFFAHLARMKLIQRWPLMRSVSPENVSEHSLQVAFVAHALALIKNKKFGGTLNPERIALLAMYHDSSEVLTGDLPTPVKYYNPEIAKEYKKIEAAAEHKLLSMLPEEFQEDFAPFLLSHSSHEEDSQIVKQADSICAYLKCLEELSAGNHEFALAKKRLDVTLQERKTPEMEYFLNTFAPSFELSLDEIS
What is the function of this protein?
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
What are the official names of this protein?
5'-deoxynucleotidase VP0926, 5'-deoxyribonucleotidase, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the 5DNU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSP1_CROAD
Sequence: MVLIRVLANLLILQLSYAQKSSELVIGGDECNINEHRFLVALYDYWSQSFLCGGTLINEEWVLTAKHCDRTHILIYVGVHDRSVQFDKEQRRFPKEKYFFDCSNNFTKWDKDIMLIRLNKPVSYSEHIAPLSLPSSPPIVGSVCRAMGWGQTTSPQETLPDVPHCANINLLDYEVCRTAHPQFRLPATSRTLCAGVLEGGIDTCNRDSGGPLICNGQFQGIVFWGPDPCAQPDKPGLYTKVFDHLDWIQSIIAGEKTVNCPP
What is the function of this protein?
Snake venom serine protease that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine proteinase 1, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RNPH_XANCP
Sequence: MSFSRPSGRTADQLRPVRIERAFTRHAEGSVLVSFGDTRVLCTASVENRVPNFLRGKGEGWVTAEYGMLPRSTHTRSDREAARGKQGGRTLEIQRLIGRALRACVDRNALGERTITLDCDVLQADGGTRTAAITGAYVALADAVNLLLKRGDIKKHPLIGAVAAVSVGIYRGEPVLDLDYPEDSDCDTDMNVVMNDGGGFIELQGTAEGHAFRRDELNALLALAEKGVGELFELQRAALAG
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: REX_BACC0
Sequence: MEQQKIPQATAKRLPLYYRFIQNLSLSGKQRVSSAELSEAVKVDSATIRRDFSYFGALGKKGYGYNVNYLLSFFRETLDQDDITRVALIGVGNLGTAFLHYNFTKNNNTKIEMAFDVSEEKVGTEIGGIPVYHLDELEERLSSDIQVAILTVPATVAQSVADRLAETNVHGILNFTPARLNVSDNIRIHHIDLAVELQTLVYFLKNYPQ
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSUD_BUTSP
Sequence: MSLNIFWFLPTHGDGKYLGTSDGARAVDHGYLQQIAQAADRLGFGGVLIPTGRSCEDSWLVAASLIPVTQHLKFLVALRPGIISPTVAARQAATLDRLSNGRALFNLVTGGDPDELAGDGLHLNHQERYEASVEFTRIWRKVLEGENVDYDGKHIQVKGAKLLYPPIQQPRPPLYFGGSSEAAQDLAAEQVELYLTWGEPPAAVAEKIAQVREKAAAQGREVRFGIRLHVIVRETNEEAWAAADRLISHLDDETIARAQASLARFDSVGQQRMAALHGGNRDNLEVSPNLWAGVGLVRGGAGTALVGDGPTVAARVKEYADLGIDTFIFSGYPHLEESYRVAELLFPHLDVQRPEQPKTRGYVSPFGEMVANDILPKSVSQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: C90C1_ARATH
Sequence: MQPPASAGLFRSPENLPWPYNYMDYLVAGFLVLTAGILLRPWLWLRLRNSKTKDGDEEEDNEEKKKGMIPNGSLGWPVIGETLNFIACGYSSRPVTFMDKRKSLYGKVFKTNIIGTPIIISTDAEVNKVVLQNHGNTFVPAYPKSITELLGENSILSINGPHQKRLHTLIGAFLRSPHLKDRITRDIEASVVLTLASWAQLPLVHVQDEIKKMTFEILVKVLMSTSPGEDMNILKLEFEEFIKGLICIPIKFPGTRLYKSLKAKERLIKMVKKVVEERQVAMTTTSPANDVVDVLLRDGGDSEKQSQPSDFVSGKIVEMMIPGEETMPTAMTLAVKFLSDNPVALAKLVEENMEMKRRKLELGEEYKWTDYMSLSFTQNVINETLRMANIINGVWRKALKDVEIKGYLIPKGWCVLASFISVHMDEDIYDNPYQFDPWRWDRINGSANSSICFTPFGGGQRLCPGLELSKLEISIFLHHLVTRYSWTAEEDEIVSFPTVKMKRRLPIRVATVDDSASPISLEDH
What is the function of this protein?
Involved in brassinosteroid (BR) biosynthesis (PubMed:15703058, PubMed:17138693).  Converts typhasterol (TY) to cathasterone (CS) and 6-deoxotyphasterol (6-deoxoTY) to 6-deoxocathasterone (6-deoxoCT) (PubMed:15703058).  C-23 hydroxylase that converts directly (22S,24R)-22-hydroxy-5-alpha-ergostan-3-one and 3-epi-6-deoxocathasterone to 3-dehydro-6-deoxoteasterone (6-deoxo3DT, 6-deoxo3DHT) and 6-deoxotyphasterol (6-deoxoTY), respectively (PubMed:17138693).  These C-23 hydroxylation shortcuts bypass campestanol, 6-deoxocathasterone, and 6-deoxoteasterone (6-deoxoTE) (PubMed:17138693).  Catalyzes also the conversion of cathasterone to teasterone (TE), (22S,24R)-22-hydroxyergost-4-en-3-one (22-OH-4-en-3-one) to (22R,23R)-22,23-dihydroxy-campest-4-en-3-one (22,23-diOH-4-en-3-one) and (22S)-22-hydroxycampesterol (22-OHCR) to (22R,23R)-22,23-dihydroxycampesterol (22,23-diOHCR) (PubMed:17138693).  Required for the regulation of polar elongation of leaf cells (PubMed:9694802, PubMed:10430960).  Required for the longitudinal elongation of floral organs (PubMed:10430960).
What are the official names of this protein?
3-epi-6-deoxocathasterone 23-monooxygenase CYP90C1, 3-dehydro-6-deoxoteasterone, (22R,23R)-22,23-dihydroxy-campest-4-en-3-one synthase, (22R,23R)-22,23-dihydroxycampesterol synthase, 6-deoxoteasterone synthase, Cytochrome P450 90C1, Protein ROTUNDIFOLIA 3, Teasterone synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: ACSA_DROME
Sequence: MPAEKSIYDPNPAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPISIKWMEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKDHGIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLLITADGAWRGEKPLYLKALCDTALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWTDDRDYWWHEEMEDKEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTADVGWITGHTYVVYGPLANGATSVIFEGTPFFPGNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVLKHNLSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPGATPMKPGSASFPFFGVKPTLLDECGIEIKGEGEGYLVFSQPWPGMMRTLYNNHERFEDTYFSKFPGYYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGECLYCFITPNENEVFDQKLISDLKKMVRERIGPFAMPDVIQNAPGLPKTRSGKIMRRVLRKIAVNDRNVGDTSTLADEQIVEQLFANRPVEAK
What is the function of this protein?
Activates acetate so that it can be used for lipid synthesis or for energy generation.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, Acetate--CoA ligase, Acetyl-CoA synthetase, ACS, AceCS, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BHCA_PARDP
Sequence: MTSQNPIFIPGPTNIPEEMRKAVDMPTIDHRSPVFGRMLHPALEGVKKVLKTTQAQVFLFPSTGTGGWETAITNTLSPGDKVLAARNGMFSHRWIDMCQRHGLDVTFVETPWGEGVPADRFEEILTADKGHEIRVVLATHNETATGVKSDIAAVRRALDAAKHPALLFVDGVSSIGSMDFRMDEWGVDIAVTGSQKGFMLPPGLAIVGFSPKAMEAVETARLPRTFFDIRDMATGYARNGYPYTPPVGLINGLNASCERILAEGLENVFARHHRIASGVRAAVDAWGLKLCAVRPELYSDSVSAIRVPEGFDANLIVSHALETYDMAFGTGLGQVAGKVFRIGHLGSLTDAMALSGIATAEMVMADLGLPIQLGSGVAAAQEHYRQTTAAAQKKAA
What is the function of this protein?
Catalyzes the transamination of glyoxylate into glycine using L-aspartate as the preferred amino group donor.  Is essential for the growth of P. denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC).  Can catalyze the reverse reaction in vitro, and also use L-serine and L-glutamate as amino group donor, but with much less efficiency than L-aspartate.
What are the official names of this protein?
L-aspartate--glyoxylate aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Protein: VATD_SULAC
Sequence: MSSRKVLPTKINLINLRRQIRLIRTIKRLLENKREVLLLYLRQYADEYEKVYNEVSKVLSDVYSTYLQGVASEGLSTIQTYADSIPSSLNVNTSIKVLFGVKIPVVDLDESTIQQQPFGNLEISPYILKSREQMSYAFKKILTLIEIESSIRALSGELRKTQRLINAIDTSILPFYQSSSKYIKSVLDDRTREEFTRLKMVRKLLQRRR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: LAP3_TRIVH
Sequence: MKVFAIAAVAALTAVAVAGPVRPSGDKYLIELGPGKTQWVTKDQKHKMRAAGQTFIDITNEIGTNFVATKPVAANYPKNIAHSSMVSSMIANLSKENLMRDLQAMSEFNNRYYESQTGVESANWLMEQVKKVIDESGAQGAKVEKIDNQFNQFNIIATIPGSSESTVIVGAHQDSINQEDPMGGRAPGADDNGSGSVVVLEALRGVLGSKAFRAANNTNTLEFHWYAGEEGGLLGSQTVFSKYKSDGRQVKAMLNQDLAGFKGQGQEQFGLITDNTNQELNQFCKMIVEKYASIPIVDTECGYACSDHASADRNGFPASMVAETAFEDSNPHIHSADDTVEYLDFDHMLEHAKVALGFMTELGMASNL
What is the function of this protein?
Probable extracellular aminopeptidase which contributes to pathogenicity.
What are the official names of this protein?
Probable leucine aminopeptidase TRV_05750, Leucyl aminopeptidase TRV_05750.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28E subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL11_TRIEI
Sequence: MAKKVVAVIKLAITAGKANPSPPIGPALGQHGVNIMAFCKEYNAKTADQAGTVVPVEISVYEDRSFTFVLKTPPAAVLIKKAAGVESGSSEPNRTKVGSITQAQLQEIAQTKMPDLNANNIEAAMKIVAGTARNMGITISD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: KIT_PIG
Sequence: MRGARRAWDFLFVLQLLLRVQTGSSQPSVSPEELSPPSIHPAKSELIVSAGDEIRLFCTDPGSVKWTFETLGQLSENTHAEWIVEKAEAMNTGNYTCTNEGGLSSSIYVFVRDPEKLFLVDPPLYGKEDNDALVRCPLTDPEVTNYSLTGCEGKPLPKDLTFVADPKAGITIKNVKREYHRLCLHCSANQGGKSVLSKKFTLKVRAAIRAVPVVAVSKASYLLREGEEFAVMCLIKDVSSSVDSMWIRENSQTKAQVKRNSWHQGDFNFLRQEKLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMMNTTVFVNDGEDVDLIVEYEAYPKPEHRQWIYMNRTATDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNADVNSSVTFNVYVNTKPEILTHDRLMNGMLQCVAAGFPEPTIDWYFCPGTEQRCSVPVGPVDVQIQNSSVSPFGKLVIHSSIDYSAFKHNGTVECRAYNDVGKSSAFFNFAFKEQIHAHTLFTPLLIGFVIAAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPHRENPAVDHSVRINSVGSSASSTQPLLVHEDV
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.  In response to KITLG/SCF binding, KIT can activate several signaling pathways.  Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL.  Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase.  Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1.  Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor.  Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.  Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
What are the official names of this protein?
Mast/stem cell growth factor receptor Kit, SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SGRW_PEA
Sequence: MDTLTSAPLLTTKFKPSFSPQQKPCFPHRRRFENGKKNQSIVPVARLFGPAIFEASKLKVLFLGIDENKHPGNLPRTYTLTHSDVTSKLTLAISQTINNSQLQGWYNRLQRDEVVAQWKKVKGKMSLHVHCHISGGHFLLDIFARLRYFIFCKELPVVLKAFVHGDGNLFNNYPELEESLVWVFFHSKIREFNKVECWGPLKEASQPTSGTHSDLKLPQSCEEDCECCFPPLNLSPIPCSNEVINNTYEPIDGIGTQHGNL
What is the function of this protein?
Probably involved in the disassembling mechanism of the intact light-harvesting complex of photosystem II (LHCII) in the thylakoid membranes.  Required for the chlorophyll breakdown pathway.  Acts independent and upstream of pheophorbide a oxygenase (PAO).
What are the official names of this protein?
Protein STAY-GREEN, chloroplastic, Protein STAYGREEN.
What is the protein family that this protein belongs to?
Belongs to the staygreen family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GHC1_HUMAN
Sequence: MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQDPQA
What is the function of this protein?
Mitochondrial glutamate/H(+) symporter.  Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (PubMed:11897791).  Plays a role in the control of glucose-stimulated insulin secretion (By similarity).
What are the official names of this protein?
Mitochondrial glutamate carrier 1, GC-1, Glutamate/H(+) symporter 1, Solute carrier family 25 member 22.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: COX2_ALLMI
Sequence: MANPTHLGFQDAMSPLMEELLYFHDHTLMILFLISSLVFYMIFALLFPKLYYPNTSDVQEVEVIWTVLPAIVLISIALPSLRTLYLMDETNNPCLTIKVTGHQWYWSYEYTDFSTLEFDSYMIPTQDLPQGHFRLLEVDHRMITPTNSTIRVLITAEDVLHSWAIPSIGTKMDAVPGRLNQVMITLANPGVFYGQCSEICGANHSFMPITMETIPLNHFQLWLEDSILS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KAD2_DROME
Sequence: MAPNAAVPVERYEPENIGINAILLGPPGSGKGTQAPLLKEKFCVCHLSTGDMLRAEISSGSKLGAELKKVMDAGKLVSDDLVVDMIDSNLDKPECKNGFLLDGFPRTVVQAEKLDTLLDKRKTNLDAVIEFAIDDSLLVRRITGRLIHQASGRSYHEEFAPPKKPMTDDVTGEPLIRRSDDNAEALKKRLEAYHKQTKPLVDYYGLRGLHFKVDAAKKSSDVFSTIDSIFQRKRPAQIQL
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: HLDE_ECOLI
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: CAMP_CEBCA
Sequence: MKTQRDGPSLGRWSLVLLLLGLTMPLAITAQVLSYQEAVLRAVDGLNQRSLDANLYRLLNLDPRPTLDGDPDTPKPVSFTVKETVCPRTIQRSPEECDFKKDGLVKRCVGTVILNQARDSFDISCDKDERKVARLGGFLQKAREKIARGFKKIGQKINDFLGKLAPRTEA
What is the function of this protein?
Exhibits antimicrobial activity against E. coli and B. megaterium (in vitro).
What are the official names of this protein?
Cathelicidin antimicrobial peptide.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YFFB_ECOLI
Sequence: MVTLYGIKNCDTIKKARRWLEANNIDYRFHDYRVDGLDSELLNDFINELGWEALLNTRGTTWRKLDETTRNKITDAASAAALMTEMPAIIKRPLLCVPGKPMLLGFSDSSYQQFFHEV
What are the official names of this protein?
Protein YffB.
What is the protein family that this protein belongs to?
Belongs to the ArsC family.
Protein: Y948_STRPG
Sequence: MYSIKCDDNKAMPRERLMRLGAESLSNQELLAILLRTGNKEKHVLELSSYLLSHLDSLADFKKMSLQELQHLAGIGKVKAIEIKAMIELVSRILATDKTLTDSVLTSVQVAEKMMAALGDKKQEHLVVLYLDNQNRIIEEKTIFIGTVRRSLAEPREILYYACKNMATSLIVIHNHPSGNIEPSSNDYCFTEKIKRSCEDLGIICLDHIIVSYKDYYSFREKSTLF
What are the official names of this protein?
UPF0758 protein SpyM50948.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: PAE1_ARATH
Sequence: MKTLLYWGWSSLAGLILFSILAHGEMKTFNESNGTNANVLMVGLTLVQAAAAKGAVCLDGSVPGYHLCRGYGSGANNWIIQLQGGAWCDSIQNCQSRKGSGYGSSTLMEKELAFLGLLSNKAAENPDFYNWNKVKVRYCDGASFDGDSENKAAQLQYRGKRIFLAVMEDLMEKGMRQAKQALLSGCSSGGLSAILRCDDFNNLFPPTTTVKCMSDAGFFLDAVDVSGGHSLRRMYSGVVNTQGLQNTLPPTCTSHIKPFLCFFPQYIINQVKTPLFILNSGFDSWQIGNSLAPPSADKSGSWHNCSFSFRCTASQMHFLEGFKMSMLDALKTFSKFSKNGVLITSGWAHCQAERQDTWFPGYSGAGKAKGIAVAVGDWYFERTKQNSS
What is the function of this protein?
Hydrolyzes acetyl esters in homogalacturonan regions of pectin.  In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions.  Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
What are the official names of this protein?
Pectin acetylesterase 1.
What is the protein family that this protein belongs to?
Belongs to the pectinacetylesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RHGE_ASPNC
Sequence: MTWSTSFLVATSLLSIINSVHAQLTGSVGPLTSVIDKAAVKTCNVCDYGASSDNTTGVGQPIIDAFTDCGSGGLIHVPEGDYLLKDWVSSENGSAWSIQLDGVLHWDSSPSAQSYIFAITGGSDSELSSSNATGAIQGSGYLYHRHNTYTSPRMLYISGVSDWTVHDLVLVNSPMPHFVIDGGYNGEAYNMAICGGDHGGLDGIDLYGGNIWIHLMVTNKDECVTSKTNSHNFLIENIYCNPSGGCAIGSLGSSVNVTNILYRNVYTWDSNQMMMIKTNGGLGNVSNIVFENFIGHGNVNSLDLDSYWSSMNAIDGVGIYYHNITIYNWTGTAIDGETRPPIRVICPEDMPCTEITLVQIDLLVEEGRYDEYYCAIACGGYCLDSATSTLTTYTTTTYGNSASTGYEAPTMADDLATAFGTTASIPTPTTPASFFPGVAPVSAVAGSS
What is the function of this protein?
Pectinolytic enzymes consist of four classes of enzymes: pectine lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins (By similarity).
What are the official names of this protein?
Probable rhamnogalacturonase E, RGase E, RHG E.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.