PharMolix/UniProtQA huggingface dataset:
Protein: ATIF2_CAEEL
Sequence: MLSVSRAATRMTGMVARFSAGGHGDGAGRGGGSGGSIRDAGGAFGKMEAAREDEYFYKKQKAQLQELREHIQEEVKHHEGQLENHKKVLERHQQRISEIEAQERALGKE
What is the function of this protein?
Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria.  Activity is pH dependent.
What are the official names of this protein?
ATPase inhibitor mai-2, mitochondrial, ATP synthase F1 subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the ATPase inhibitor family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RFX2_MOUSE
Sequence: MQNSEGGADSPASVALRPAAQPMPASPQRVLVQAAGSTPKGTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYAYNPDPQLYAPSSAASYFETPGGTQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGAYLIHGGMDGTRHSLAHTARSSPATLEMAIETLQKSEGLAPHKGGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHGMPDQAMATQGQHHQQYIDVSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDSCASLPASDEDPEVTLLPKEKLISLCKCEPILQWMRSCDHILYQTLVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHSGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKEDIGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI
What is the function of this protein?
Transcription factor that acts as a key regulator of spermatogenesis (PubMed:26248850, PubMed:26162102, PubMed:26853561).  Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (PubMed:26162102, PubMed:26853561).  Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:15229132, PubMed:26162102).  Probably activates transcription of the testis-specific histone gene H1-6 (PubMed:15229132).
What are the official names of this protein?
DNA-binding protein RFX2, Regulatory factor X 2.
What is the protein family that this protein belongs to?
Belongs to the RFX family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly expressed in the nucleus and at lower level in cytoplasm.
Protein: ATPL_MYCLE
Sequence: MDPMIAQGALIGGGLIMAGGAIGAGIGDGMAGNALVSGIARQPEAQSRLFTPFFITVGLVEAAYFINLAFMALFVFATPVK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL10_BACLD
Sequence: MSSAIETKKVVVEEITSKLKESKSTIIVDYRGLNVAEVTELRKQLREANVEFKVYKNTMTRRAVEQAELDGLNDFLTGPNAIAFSTEDVVAPAKVLNEFAKKHEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALATKAVAEQKEEQGA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y181_MYCTU
Sequence: MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLLVNNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQDSAGNSGVIYPGLAQRMSAGTGILHSEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAALTLHNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDADARGLTANEPSEVLIWEMHAKLGDSAT
What is the function of this protein?
Putative quercetin 2,3-dioxygenase.
What are the official names of this protein?
Putative quercetin 2,3-dioxygenase Rv0181c, Putative quercetinase, Pirin-like protein Rv0181c.
What is the protein family that this protein belongs to?
Belongs to the pirin family.
Protein: RL4_STRPS
Sequence: MANVTLFDQTGKEAGQVVLSDAVFGIEPNESVVFDVIISQRASLRQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLPQKVRRLALKSVYSEKVAENKFVAVDALSFTAPKTAEFAKVLAALSIDSKVLVILEEGNEFAALSARNLPNVKVATATTASVLDIANSDKLLVTQAAISKIEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PTPRA_MOUSE
Sequence: MDSWFILVLFGSGLIHVSANNATTVSPSLGTTRLIKTSTTELAKEENKTSNSTSSVISLSVAPTFSPNLTLEPTYVTTVNSSHSDNGTRRAASTESGGTTISPNGSWLIENQFTDAITEPWEGNSSTAATTPETFPPADETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPFLSLAVSKDAVKALNKTTPLLERRFIGKSNSRGCLSDDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNVRVSVEDVTVLVDYTVRKFCIQQVGDVTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK
What is the function of this protein?
Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (PubMed:22801373).  Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (PubMed:22801373).
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha, LCA-related phosphatase, PTPTY-28.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Note=Localizes to focal adhesion sites following integrin engagement.
Protein: AROK_STRCO
Sequence: MSAPLIVLVGPMGVGKSTVGQLLAERLGTGYRDTDEDIVTAQGRAIAEIFVDEGEAAFRTLEKEAVRTALAEHEGVLALGGGAILDADTRALLAGQRVVYLSMDVEEAVKRTGLNAARPLLAVNPRKQWRELMEARRHLYEDVATAVVATDGRTPEEVTQAALDAVELKEA
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMC_BACSU
Sequence: MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAIRWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTRRVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSIFEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEKKKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKIQALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETVLKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHSQVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVKEVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQNSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTVLITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDVTKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQVAEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQKQTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSFLTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMKRLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKRVKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMTKRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNLLSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIVITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ
What is the function of this protein?
Required for chromosome condensation and partitioning.
What are the official names of this protein?
Chromosome partition protein Smc.
What is the protein family that this protein belongs to?
Belongs to the SMC family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Probably associated with the nucleoid.
Protein: CXB4_RAT
Sequence: MNWGFLQGILSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFICNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHRLKHGPDAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPRVVACSVQPCPHTVDCYISRPTEKKVFTYFMVVTAAICILLNLSEVAYLVGKRCMEVFRPRRQKTSRRHQLPDTCPPYVISKGHPQDESTVLTKAGMATVDAGVYP
What is the function of this protein?
Structural component of gap junctions (By similarity).  Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells.  They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity).  Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity).
What are the official names of this protein?
Gap junction beta-4 protein, Connexin-30.3, Cx30.3.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Beta-type (group I) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Note=Colocalizes with GJB2 at gap junction plaques in the cochlea.
Protein: MDH_AZOC5
Sequence: MARSKIALIGAGQIGGTLALLAGLKELGDVVLFDLVEGVPQGKALDLAELSPVAGFDAAFAGTGAYEQIAGADVVIVTAGVPRKPGMSRDDLLAVNLKVMEQAGAGIAKYAPDAFVICVTNPLDAMVWALQKASGLPRHKVVGMAGVLDSARLRYFLADEFNVSVEDVTAMVLGGHGDTMVPLMRYCTVAGIPVPDLIRIGWTSTDRIEAIVTRTRNGGAEIVELLKSGSAFYAPAASAIVMAESYLKDKKRVLPVAAPLSGEYGFRDLYVGVPAVIGARGVERIVELELDRAERAQFEQSVASVQGLVDACAKIAPDLVR
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: THA8L_ARATH
Sequence: MTAIRVCSRKFPTFASIFFQNITRNPSIHRISFSNLKPKTLLHPIPPKPFTVFVSRFHDGRPRGPLWRGKKLIGKEALFVILGLKRLKEDDEKLDKFIKTHVFRLLKLDMLAVIGELERQEETALAIKMFEVIQKQEWYQPDVFMYKDLIVSLAKSKRMDEAMALWEKMKKENLFPDSQTYTEVIRGFLRDGCPADAMNVYEDMLKSPDPPEELPFRVLLKGLLPHPLLRNKVKKDFEELFPEKHAYDPPEEIFGRC
What is the function of this protein?
Binds weakly to specific single strand RNA (ssRNA).
What are the official names of this protein?
Protein THYLAKOID ASSEMBLY 8-like, chloroplastic, AtTHA8L.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PPAF1_HOLDI
Sequence: MKQVHFFILWFFVLNLYSIKAQAGCRTPNGENARCVPINNCKILYDSVLTSDPEVIRFLRASQCGYNGQPLVCCGSSASYQPPPTSASIRNRRPELLPNDCGYQVEADKILNGDDTVPEEFPWTAMIGYKNSSNFEQFACGGSLINNRYIVTAAHCVAGRVLRVVGALNKVRLGEWNTATDPDCYGAVRVCVPDKPIDLGIEETIQHPDYVDGSKDRYHDIALIRLNRQVEFTNYIRPVCLPQPNEEVQVGQRLTVVGWGRTETGQYSTIKQKLAVPVVHAEQCAKTFGAAGVRVRSSQLCAGGEKAKDSCGGDSGGPLLAERANQQFFLEGLVSFGATCGTEGWPGIYTKVGKYRDWIEGNIRP
What is the function of this protein?
Serine endopeptidase which, by cleaving prophenoloxidase PPO1 and PPO2, is required for the activation of the prophenoloxidase cascade probably following the recognition of pathogen-derived products.
What are the official names of this protein?
Phenoloxidase-activating factor 1, Prophenoloxidase-activating factor I, Serine protease PPAF-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. CLIP subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in the hemolymph.
Protein: SCNAA_CANLF
Sequence: MEFPFGSLETTNFRRFTPESLVEIEKRIAAKQAAKKAKGKHREQKDQEEKPRPQLDLKACNQPPKFYGELPAELVGEPLEDLDPFYSTHRTFMVLDKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVGMTQTELPDRIEYVFTVIYTFEALIKILARGFCLNEFAYLRDPWDWLDFSVITLAYIGEATALRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKCVKNCAALNETGNYSSYGKQEWNFCHRDEDFYYNKPGTSDPLLCGNGSDAGHCPKGYLCLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATIDEIEAKEKTFQETLEMPRKEQEVLAALGIDTASLHSCNGSPLPSKNASERMRRMKPRVSEGSTDDNKSPQSDPYNQRRMSFLGLTSGRRRASHGSVFHFRTPCLDTSFPDGVTDDGVFPGDRESHRGSLLLGGGTSQQGPLLRSPLPQPPNPGSGHGEDGHSTLPTGELAPGGIEVSAFDAGQKKTFLSAEYLNEPFRAQRAMSVVSIMTSVLEELEESERRCPPCLTSFAQKYLIWECCPTWVKLKTVLFGIVTDPFAELTTTLCIVVNTVFMAMEHHGMSSAFEAMLQIGNIVFTVFFTAEMVFKIIAFDPYYYFQKRWNIFDCIIVTVSLIELGAARKGSLSVLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRDNRRNISAPNEEWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFTALLLNSFSADNLATPDEDGEVNNLQVALARIQAFGHRTKKAICNFFTRPCLLPWPKAEPQLVVKLPLSSSKAENHIAANAAVGSPGGLSVSRGLRDDHSDFITNPNIWVSVPIAEGESDLDDLEEDGEEDSQSSQQEVILQGQEQLQVETCEGHTAPRSPGSGMSSEDLASYVDEKWKDEAVAQAPAEGGDDSSSSGGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCLRRCPCCKVDISKFPWTVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYHLDQKPTVKALLEYTDRMFTFIFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLIAKILQYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSTMGVNFFAGKFGRCINKTNEYFSLVPLSIVNNISDCKYQNHTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDARDVNLQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTKQAFDIVIMVLICLNMITMMVETDEQSAEKTKILNKINQFFVAVFTGECVMKMFALRHYYFTNGWNVFDFIVVVLSIGSLVFSVILTSLENYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFPHVSWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAVILENFNVATQESSEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANIEEKFMATNVSKASYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMTISNPPAVPRAEEAVPPPDEAFVEFMVNENCALPDKSETASAASFPPSYDSVTRGLSDQINMSTSSSMQNEDEGTSKKVTAPGP
What is the function of this protein?
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient.  Plays a role in neuropathic pain mechanisms (By similarity).
What are the official names of this protein?
Sodium channel protein type 10 subunit alpha, NaNG, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=It can be translocated to the cell membrane through association with S100A10.
Protein: REPA_MSVSE
Sequence: MTSSSSNRPFSHRSPNTFLTYPQCPEQPEIISQRIWDLCSHWTPLYIICAREAHRDGNQCLHALIQTEKPVRTTDSRFFDIDGFHPNIQSAISPNKVRDYITKEPLALFERGTFIPRKKSFLGNSSKGNSDKKPSKDEIMRDIISHATSKQEYLSMVQKSLPYDWSTKLQYFEYSANKLFPDIQEEFINPHPTSEPDLLCNESIKDWLQPNIYQVSPQAYLLLQPNCYSIDDAISDLEWLDDLTSKQIMEQGSAASTSSVQQGQENLHGPEA
What is the function of this protein?
Implicated in enhancement of V-sense gene expression.  Acts a an inhibitor of C-sense gene transcription (By similarity).
What are the official names of this protein?
Replication-associated protein A, RepA.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: CNU_ECOL6
Sequence: MTVQDYLLKFRKISSLESLEKLYDHLNYTLTDDQELINMYRAADHRRAELVSGGRLFDLGQVPKSVWHYVQ
What is the function of this protein?
Modifies the set of genes regulated by H-NS; Hha and cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA.  The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC.
What are the official names of this protein?
OriC-binding nucleoid-associated protein, H-NS/StpA-binding protein 2, Transcription modulator YdgT.
What is the protein family that this protein belongs to?
Belongs to the Hha/YmoA/Cnu family.
Protein: PYRD_RHOOB
Sequence: MYHLLLRVMFRLPPERIHHLAFAAMRLVTRFSPLRQLVGRVLVVDDPVLRNTVFGLDFPAPLGLAAGFDKDATGVDAWGPLGFGFAEVGTVTAQAQPGNPAPRLFRLPADRALINRMGFNNHGAGNAANHLRQRRAGVPIGANIGKTKIVDAADAPADYTASAHLLGPLADFMVVNVSSPNTPGLRDLQAVESLRPLLRAVLDSVTVPVLVKIAPDLSDDDVDAVADLALELGLAGIVATNTTIRRDGLNTPDDEVTAIGAGGLSGPPVAERSLEVLRRLHARVGDRLVLISVGGIETVDQAWERILAGASLVQGYTGFIYGGPFWARRIHKGLARKVREAGYSSVADAVGAGAVR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RPPH_XANCP
Sequence: MIDPDGFRPNVGIVLMREDGQVFWARRVRRDGWQFPQGGMNTDETPVEAMYRELREETGLLPEHVELLGATPGWLRYRLPSRAVRRNERQVCIGQKQVWFLLQFTGQESHLKLDHTDSPEFDHWRWVDFWYPVEHVVMFKRGVYARALRHLAPLAQTVAGPAAVGVMPQRALEAWLPGSSAAGHDRPRKRPRKRGGVLPVRINND
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: Y3_CYLCV
Sequence: MGLEDSVKQLQGAIEELKGLISSVEEMKEIVKRESEDSIQEYLRSFLEPLAKDNPLFTQKHIFGKYKPERNEKKCSHIDGNYWPHLKHTFHPQLNYIVDLLEEIRNCTCKEKQHDKQLVPLPTPAESSKKPEECTNNCNCDKCRQKEKCLTIGEMSELLQNLIKIPKQSKYLEKPALF
What are the official names of this protein?
Uncharacterized protein 3.
Protein: A1AT_BOVIN
Sequence: MALSITRGLLLLAALCCLAPISLAGVLQGHAVQETDDTSHQEAACHKIAPNLANFAFSIYHHLAHQSNTSNIFFSPVSIASAFAMLSLGAKGNTHTEILKGLGFNLTELAEAEIHKGFQHLLHTLNQPNHQLQLTTGNGLFINESAKLVDTFLEDVKNLYHSEAFSINFRDAEEAKKKINDYVEKGSHGKIVELVKVLDPNTVFALVNYISFKGKWEKPFEMKHTTERDFHVDEQTTVKVPMMNRLGMFDLHYCDKLASWVLLLDYVGNVTACFILPDLGKLQQLEDKLNNELLAKFLEKKYASSANLHLPKLSISETYDLKSVLGDVGITEVFSDRADLSGITKEQPLKVSKALHKAALTIDEKGTEAVGSTFLEAIPMSLPPDVEFNRPFLCILYDRNTKSPLFVGKVVNPTQA
What is the function of this protein?
Inhibitor of serine proteases.  Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.  Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity).
What are the official names of this protein?
Alpha-1-antiproteinase, Alpha-1-antitrypsin, Alpha-1-proteinase inhibitor, Serpin A1.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNMA_STRZP
Sequence: MSDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYARVARDEDGTVHMLRGVDNGKDQTYFLSQLSQEQLQKTMFPLGHLEKPEVRKLAEEAGLSTAKKKDSTGICFIGEKNFKNFLSNYLPAQPGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNAPWFVVGKDLSKNILYVGQGFYHDSLMSTSLEASQVHFTREMPEEFTLECTAKFRYRQPDSKVTVHVKGDKAEVIFAEPQRAITPGQAVVFYDGEECLGGGLIDNAYRDGQVCQYI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPD_STAAC
Sequence: MKHDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVDTMPNIVHDWIAKLERNQQSLGIITQNIDGLHSDAGSQHVDELHGTLNRFYCNVCHKSYTKSDVIDRTLKHCDNCGGAIRPDIVLYGEMLDQPTIIRALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSLMTE
What is the function of this protein?
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
What are the official names of this protein?
NAD-dependent protein deacetylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class U subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYTS_STAAC
Sequence: MLSLTMLLLERVGLIIILAYVLMNIPYFKNLMNRRRTWKARWQLCIIFSLFALMSNLTGIVIDHQHSLSGSVYFRLDDDVSLANTRVLTIGVAGLVGGPFVGLFVGVISGIFRVYMGGADAQVYLISSIFIGIIAGYFGLQAQRRKRYPSIAKSAMIGIVMEMIQMLSILTFSHDKAYAVDLISLIALPMIIVNSVGTAIFMSIIISTLKQEEQMKAVQTHDVLQLMNQTLPYFKEGLNRESAQQIAMIIKNLMKVSAVAITSKNEILSHVGAGSDHHIPTNEILTSLSKDVLKSGKLKEVHTKEEIGCSHPNCPLRAAIVIPLEMHGSIVGTLKMYFTNPNDLTFVERQLAEGLANIFSSQIELGEAETQSKLLKDAEIKSLQAQVSPHFFFNSINTISALVRINSEKARELLLELSYFFRANLQGSKQHTITLDKELSQVRAYLSLEQARYPGRFNININVEDKYRDVLVPPFLIQILVENAIKHAFTNRKQGNDIDVSVIKETATHVRIIVQDNGQGISKDKMHLLGETSVESESGTGSALENLNLRLKGLFGKSAALQFESTSSGTTFWCVLPYERQEEE
What is the function of this protein?
Member of the two-component regulatory system LytR/LytS that regulates genes involved in autolysis, programmed cell death, biofilm formation and cell wall metabolism.  Participates also in sensing and responding to host defense cationic antimicrobial peptides (HDPs).  Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of LytR.  In turn, LytR binds to the upstream promoter regions of target genes including lrgA and lrgB, to positively regulate their expression.  Possesses also a phosphatase activity that dephosphorylates and thus inactivates LytR.
What are the official names of this protein?
Sensor histidine kinase/phosphatase LytS, Autolysin sensor kinase.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTND_YERPB
Sequence: MSGLTIFSDQQPEKPLWQSHNAEEIQQQLTAIGVRFERWQADCELGENPQPEAVIAAYQHEIDRLVAENGYKSWDVISMRPDNPQREALREKFLSEHTHGEDEVRFFVEGSGLFCLHLNEKVYQILCEKNDLLSVPADIPHWFDMGSAPNFTAIRVFDNPEGWIARSTGDNIADGYPRLA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: ZUPT_ECOLC
Sequence: MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSVMGFSLVLLQTAGIG
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.