PharMolix/UniProtQA huggingface dataset:
Protein: NS1_I73A4
Sequence: MDSNTVSSFQVDCFLWHVRKRFADQELGDAPFLDRLRRDQKSLKGRGSTLGLDIETATRAGKQIVERILEEESDEALKMTIASVPASRYLTDMTLDEMSRDWFMLMPKQKVTGSLCIRMDQAIMDKNIILKANFSVIFERLETLILLRAFTEEGAVVGEISPLPSLPGHTNEDVKNAIGVLIGGLKWNDNTVRVSETLQRFAWRSSHENGRPSFPPKQKRKMARTIESEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: ADK_RAT
Sequence: MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNETEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPVLDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
What is the function of this protein?
Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner.  Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
What are the official names of this protein?
Adenosine kinase, AK, Adenosine 5'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL31_CAUVN
Sequence: MKQDIHPDYHFITVTLTDGSSYKTRSTYGKEGANLALDIDPRTHPAWTGGNAQLMDRGGRVSRFNAKFAGFTGKKA
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: KDM4_CAEEL
Sequence: MASAATTTHFPSSRIPSEPCASSGPLFPDDVLFTTEASSASSSSCHVENDSRPLSPTMFTDGRTPVNISAKHLKDHPLHEPTGTSEVLTFYPTMREFKNFSQYIKKIEQNGGHLKAGIAKIVAPEGWTPRPTRKDFSDVDDYEITQPARETIEATEKPGAYFKRNVTCRRKMPVREFRTLANSAQYRNPRPDLKGSEIEKHYFDNILHGEPIYGADTEGSFYDAQVEEWNMNRLGTILEDTNYEIKGVNTVYLYFGMYKTTFPWHAEDMDLYSINFLHFGAPKYWFAISSEHADRFERFMSQQFSYQNEYAPQCKAFLRHKTYLVTPELLRQAGIPYATMVQRPNEFIITFPRGYHMGFNLGYNLAESTNFASQRWIDYGKDAVLCDCNKDSVKIDMTHFMAKYRPDEYTTWWTYWYGGGRELWIPKKKKEVPKKRRQSLADASKIAKRARLGASSTATDSDGSSGSSGSEEATEGSSFMRALPAGYTVHNWQLRPDYDELLRKYKKETKLLRSDTRIDFYQEREFNHARRAEWPHCAVCQYFQPPHMNAINHTVPNSSRRLIPKWCFSKTDTKKHEDHHEPPPPLDRLLTCSNCHVTVHSHCCSGGGGGGGDDDDVTSSGEPWRCPRCRNRTDVEIRTTSCQLCELRGGALIPCQIGTDSTWAHVACALFNRRAIFDCPNRPGACFVEPSPRQQSETPRMPPRRLSEEYRAELGDLYENSRWECVVCHRTDEGLAPCVLCIEEQATTSLPTLAHVTCARRVGFVCEVRDYPRGVVMICHKHEHSYLVNKTTQQQAYTNVKVGDFVFVEDVVEPPQKLFTRGAIVRADKKETVVVDFLDNSCSRDNHVEDIISCECLFCENGDHQYGARVKVVWDDKQVYDAYFRGKGQMIEYTVRLEDGREVRHPRNRLKTKRELNAYLKK
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:16603238, PubMed:24685137).  Demethylation of Lys residue generates formaldehyde and succinate.  Involved in the negative regulation of lifespan in a germline-dependent fashion (PubMed:22212395).
What are the official names of this protein?
Lysine-specific demethylase 4, JmjC domain-containing histone demethylation protein 2, ceJMJD2, [histone H3]-trimethyl-L-lysine(36) demethylase 4, [histone H3]-trimethyl-L-lysine(9) demethylase 4.
What is the protein family that this protein belongs to?
Belongs to the JHDM3 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL38_SOLLC
Sequence: MPKQIHEIKDFLLTARRKDARTVKIKKNKDMVKFKVRCSKYLYTLCVSDFEKADKLKQSLPPGLSVQDL
What are the official names of this protein?
60S ribosomal protein L38.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL38 family.
Protein: DPCKG_PYRIL
Sequence: MTCFKLCCRRDLFAFPYPVAIWKEPPRSIEVVRDLVESYGIEQIYTVGDIVTTNFLKYSLAPTSAAVDGKTRRGLKIDKPTFFRKTIEVYNPPGYITEEAWIAVEEAVRDNVMIKVNGEEDMLSLAFIKLAPPHSVVVYGHYMGALIAIPVDWYRDAICKLFEYLEKC
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
What are the official names of this protein?
GTP-dependent dephospho-CoA kinase, Dephospho-coenzyme A kinase, DPCK.
What is the protein family that this protein belongs to?
Belongs to the GTP-dependent DPCK family.
Protein: EFP_RHIEC
Sequence: MVKVIASSVRKGNVLDVDGKLYVVLTAQNFHPGKGTPVTQVDMRRIVDGVKVSERWRTTEQVERAFVEDVNFQYLYEDGEGFHFMNPATYDQVVVSAETMGDQKAYLQEGMTCILSIHEGVPLALELPRHVTLEIVETEPVVKGQTASSSYKPAMLSNGIRTSVPPHIDAGTRVVIATEDNSYVERAKD
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_GEOSW
Sequence: MDVKWLDVPEGDTEELKRNVFFTTLEQLKAWARSNSLWPLTFGLACCAIEMMGVGGAHYDLDRFGSFFRASPRQSDVMIVSGTVTKKMAPIIRRLYDQMPEPKWVIAMGSCATAGGPYVKSYSVVKGVDQIVPVDVYIPGCPPNPAALIYGINKLKEKIRYEAKTGKKVL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MKT1_CRYNH
Sequence: MTIRGLDNYLKERKLIQSCPISTLANTRLGIDATHYLNHLLTDPNSREPLVAATGGLPLAIISKIESDLRALERHAIKPVFVFAGLPLASRPPPKGPDIKAERENQIKNEAWALYDEGQAYSAVDKLVQFNNGNFVDQRDLLRSIMRLFRHRYVEFVVAPYLGIAQLAYLLQHPKGYIHAIYSSSECLMWPVERVITSSDWNNNFQFVEKVRILNDLNLTSEQFLDFGILAGSSLSRTIPLPQSEFSIKNIADLVRHHKSGISVCQNVRQEPPYKAQFYTESFWKARLAVKFSLVLTTEGACVPLPTVITPQQQAFTVQDVPGDLEEIFSPRIPDELYFHICRGLVSAQVVGWLTSGMIIEQQPLLETGEYRRFIKDVITEGPTSPRCTTIALLADILHPDWSKRRINVHYYFDPPYAPVRGAFVPFTDALTQSLIGRCSDWMVPMFNLEMELRRQNSSTIDLKLCIGALASEELVHRTFKPKGDRVLDKKDEVVANSLWRFLEVRGFVQQNHAHSLIGKALYAAYTVSRVNDRFQEPIYLILELLRAGVLHGGKWGGPEAAPLLGGPSFGDEDEQNSVRLIMRCISVLPLVSRNQQWVGPLSQELLAFNAFVRGLSKSLRQLFEAVSVHLLLSGDGRRNRDDYSDIMLSLPFQTDVNTGFGILAKSYLDATSYHNQLEPITEEMIGTEGAETAKRQAILFIEENFSSVKAPVQELERGFRFWDAVMVAIRCLAEEQGPNPKLAQTVVGRDVIEQFERADKWLKPMRP
What is the function of this protein?
Involved in 3'-UTR mediated RNA regulation (By similarity).  Complexes with PBP1 to promote mRNA interactions with poly(A)-binding protein (By similarity).
What are the official names of this protein?
Post-transcriptional regulator MKT1, Inactive endonuclease MKT1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: Y925_PYRAB
Sequence: MREVAEDIEEIRRRKLLELQRKYLEQQKAQEEEARQQALIEAQIQAILRKILTPEARERLARVRLVRPELARQVELILVQLYQAGQITERIDDAKLKKILAQIEARTRREFRIKW
What are the official names of this protein?
DNA-binding protein PYRAB09250.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: EFTU1_PELTS
Sequence: MAKQKFERTKPHVNIGTIGHVDHGKTTLTAAITMVLATVGKAQVKKYDEIDNAPEERERGITINTAHVEYETEKRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVYLNKADMVDDPELLELVDMEVRELLSTYEFPGDEIPIITGSALKAMECACGKRECEWCKSIWELMDAVDEYIPTPQRAVDKPFLMPVEDVFSITGRGTVATGRIERGQVKVGDEVEIVGLQDKPRKTVVTGVEMFRKILDVGVAGDNVGCLLRGVDRKEIERGQVLAKPGSIKPHKSFSAEVYVLTKEEGGRHTPFFNGYRPQFYFRTTDVTGVVKLPEGVEMVMPGDNVRIDIDLITPIAIEEGLRFAIREGGRTVGAGVVTGIRE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 1, EF-Tu 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1383_STAES
Sequence: MTKIKEIKKVLQQEDADAAWITTPLNIFYFTGYRSEPHERLFALLIPSNEEPVLFCPKMEVEEVKQSPFKGKIIGYLDTENPFDKYSKTFSKMLIESEHLTVKRQRELTKAFNIEHYQDVDQSIKDLRNIKSEDEIINIKKAAALADKCIEIGKSFLKEGVEEREVVNHIENEIKKYGVNEMSFDTMVLFGDHAASPHGTPGDRKLQQNEFVLFDLGVVYHHYCSDMTRTIHFGTPNKEAQNIYNIVLKAETEAIKSIKPGVTIKDIDKIARDIIEEAGYGDYFPHRLGHGLGLEEHEYQDISSVNNNQLEAGMVITIEPGIYVPHVAGVRIEDDILVTENGYEILTQYEK
What are the official names of this protein?
Uncharacterized peptidase SE_1383.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: OR22C_DROME
Sequence: MTDSGQPAIADHFYRIPRISGLIVGLWPQRIRGGGGRPWHAHLLFVFAFAMVVVGAVGEVSYGCVHLDNLVVALEAFCPGTTKAVCVLKLWVFFRSNRRWAELVQRLRAILWESRRQEAQRMLVGLATTANRLSLLLLSSGTATNAAFTLQPLIMGLYRWIVQLPGQTELPFNIILPSFAVQPGVFPLTYVLLTASGACTVFAFSFVDGFFICSCLYICGAFRLVQQDIRRIFADLHGDSVDVFTEEMNAEVRHRLAQVVERHNAIIDFCTDLTRQFTVIVLMHFLSAAFVLCSTILDIMLNTSSLSGLTYICYIIAALTQLFLYCFGGNHVSESSAAVADVLYDMEWYKCDARTRKVILMILRRSQRAKTIAVPFFTPSLPALRSILSTAGSYITLLKTFL
What is the function of this protein?
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates.  The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration.  May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
What are the official names of this protein?
Odorant receptor 22c.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LRCH1_MOUSE
Sequence: MATPGSEPQAFAPALSVTALHPHLHQHHQHHQHHQHHGGTGGTGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTTAPGHDLSDTVRADLSKNRLVEVPMELCQFVSLEILNLYHNCIRVIPEAIVNLQMLTHLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLPLVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTSDSLYLPTIERPHLHQHVEDSKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNAPMSNIVEEDQTIKEDACHRLTPTKGEFQPKPSILGDSGISGQEREQLAGRADARHSGLMNYIKDQAEDCEELLRIEEDAHWHMEELLNSSKDRELDIAMIEQLREAELLQDPNGLSADIIERSILNLFPMDSGEASEFPDPSLNGQLQLETSPDREVQNDLMLQSNGSQYSPNEIRENSPSVSPTANITAPFGLKPRSGSWCPEEVQGSLQAESSPRRPQLLSRHVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEEKLCLPHHILEEKGLVKVGTTVQALLDVTVTKALFT
What is the function of this protein?
Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8.  Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration in response to chemokine stimulation.
What are the official names of this protein?
Leucine-rich repeat and calponin homology domain-containing protein 1, Calponin homology domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSCL_ANAD2
Sequence: MSFASEFKAFALKGNVVDLAVGVIIGAAFGKIVDSIVNDLVMPVVGAIFGGFDFKDYFVALKEIPPGVPHALDAVKKAGVPVFAYGSFLTIVLNFLILAFIIFLMVKQFNRMKRAEPAPAPAAPPEQVVLLREIRDALRR
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DRE1I_ORYSJ
Sequence: MCTSKLEEITGEWPPPALQAASTTSSSEPCRRLSPPSSKRPAGRTKFHETRHPVFRGVRRRGRAGRWVCEVRVPGRRGCRLWLGTFDAADAAARAHDAAMLALRGRAAACLNFADSAWLLAVPPPATLRCAADVQRAVARALEDFEQRESSSSVFPLAIDVVAEDAMSATSEPSAASDDDAVTSSSSTTDADEEASPFELDVVSDMGWSLYYASLAEGLLMEPPASGASSDDDDDAIVDSSDIADVSLWSY
What is the function of this protein?
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'.  Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription (By similarity).
What are the official names of this protein?
Dehydration-responsive element-binding protein 1I, Protein DREB1I.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: VPS27_EMENI
Sequence: MAGWFSSASPLDEQIERATASSLEDIALNLEISDLIRSKGVQPKDAMRSLKRRLENKNPNIQIATLKLTDTCVKNGGTHFLAEIASREFMDNLVSLLKAEGVPLNSSVRDLMLALIQDWAMAAQGRMDLSYLGETYRKLQMEGFQFPPKSAISGSMLESSAPPEWIDSDVCMRCRTPFSFMNRKHHCRNCGNVFDAQCSSKTLPLPHLGILQPVRVDDGCYAKLTSKPFNQGSLADRSTFKNNSITKSNVLEPRAARVESGFDEDLRRALQMSLEEAQNKSSSGYVPQPKPAQAPANTQPQPSTDEEEDADLKAAIEASLRDMEEHKQKYAAALKNNTSAESSRETPAAASLPKNPYELSPVEVENIHLFSTLVDRLQHQPPGTILREPQIQELYESIGALRPKLARSYGETMSKHDTLLDLHAKLSTVVRYYDRMLEERLSSAYSQHNLGYGPVPGGAQYPNIYPSMPSTTAEVRPGAENFYYGNSGVEPPAPARTPYSQPPLERENGVVSSSMHPPLQQPSSGPYWNPNNHSIASPQPNVNAFNSNNTPYPGPGAPSQFYTSSAYQEPEKLFQQPRQGEPESPYQPSPVTNRDSYYQSAGLPSNPVEQQPPVDHGQSPGHAQPADSRSSQSGQPKATEPSAQSYYLPQEQQQQQQQQQQQSAQGTGYQGYPQGNTNYQAPYGGDVSPISAPPPVQYQQPAAPRPVVEESLIEL
What is the function of this protein?
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 27.
What is the protein family that this protein belongs to?
Belongs to the VPS27 family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TRPD_EXIS2
Sequence: MKDVLTKLANANHLRFEEMQQAARELFAEDVTDSEIAAFLIALKAKGETAEELAGLASIMREVAVDIPVSGTDFIDNCGTGGDGSQSFNISTTAAFVLAGAGAKVAKHGNRSVSSKTGSADVLESLGVPLDVSTEEIATLLETNGIAFLFAQRMHPRVKQIMKVRRDLRIPTIFNLIGPLTNPVPLKTQLLGIYREDLLETIALTLHRLGRKRAIVLHGACGMDEASLAGTNQLVLLDQGELIRFSLHPEEVGLSVAPIEAIRGGTAAENAEILLRVLRGEAGPYRDTVLLNAGIALFAEGRVETIREGIERSAESIDSGRALEKLQYLQRMKQQEAIG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RUVB_ACIBC
Sequence: MQDRLISGTEKPEDHFDRAIRPTSLADYIGQPVVREQMEIFIGAARGRGEALDHTLIFGPPGLGKTTLANIIAREMGGNLKSTSGPVLERAGDLAAMLTNLEEGDVLFIDEIHRLSPVIEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLVAATTRAGLLTSPLRDRFGIVQRLEFYSVEDLTHIVSRSANLMDVPITVEGAEEVARRSRGTPRIANRLLRRVRDYAQVKGTGEVNHEMAQRALDMLNVDKAGLDTLDRRYLSMLLERFDGGPAGVEALAAAMAEDSGTLEDVIEPYLIQQGYVMRTARGRIATNQSYLQFGMTPPEPKN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: KGP38_PORGN
Sequence: MRKLLLLIAASLLGVGLYAQSAKIKLDAPTTRTTCTNNSFKQFDASFSFNEVELTKVETKGGTFASVSIPGAFPTGEVGSPEVPAVRKLIAVPVGATPVVRVKSFTEQVYSLNQYGSEKLMPHQPSMSKSDDPEKVPFVYNAAAYARKGFVGQELTQVEMLGTMRGVRIAALTINPVQYDVVANQLKVRNNIEIEVSFQGADEVATQRLYDASFSPYFETAYKQLFNRDVYTDHGDLYNTPVRMLVVAGAKFKEALKPWLTWKAQKGFYLDVHYTDEAEVGTTNASIKAFIHKKYNDGLAASAAPVFLALVGDTDVISGEKGKKTKKVTDLYYSAVDGDYFPEMYTFRMSASSPEELTNIIDKVLMYEKATMPDKSYLEKALLIAGADSYWNPKIGQQTIKYAVQYYYNQDHGYTDVYSYPKAPYTGCYSHLNTGVGFANYTAHGSETSWADPSLTATQVKALTNKDKYFLAIGNCCVTAQFDYPQPCFGEVMTRVKEKGAYAYIGSSPNSYWGEDYYWSVGANAVFGVQPTFEGTSMGSYDATFLEDSYNTVNSIMWAGNLAATHAGNIGNITHIGAHYYWEAYHVLGDGSVMPYRAMPKTNTYTLPASLPQNQASYSIQASAGSYVAISKDGVLYGTGVANASGVATVNMTKQITENGNYDVVITRSNYLPVIKQIQAGEPSPYQPVSNLTATTQGQKVTLKWDAPSAKKAEASREVKRIGDGLFVTIEPANDVRANEAKVVLAADNVWGDNTGYQFLLDADHNTFGSVIPATGPLFTGTASSNLYSANFEYLIPANADPVVTTQNIIVTGQGEVVIPGGVYDYCITNPEPASGKMWIAGDGGNQPARYDDFTFEAGKKYTFTMRRAGMGDGTDMEVEDDSPASYTYTVYRDGTKIQEGLTATTFEEDGVAAGNHEYCVEVKYTAGVSPKVCKDVTVEGSNEFAPVQNLTGSAVGQKVTLKWDAPNGTPNPNPNPNPGTTTLSESFENGIPASWKTIDADGDGHGWKPGNAPGIAGYNSNGCVYSESFGLGGIGVLTPDNYLITPALDLPNGGKLTFWVCAQDANYASEHYAVYASSTGNDASNFTNALLEETITAKGVRSPEAIRGRIQGTWRQKTVDLPAGTKYVAFRHFQSTDMFYIDLDEVEIKANGKRADFTETFESSTHGEAPAEWTTIDADGDGQDWLCLSSGQLDWLTAHGGTNVVASFSWNGMALNPDNYLISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAGDFTVVFEETPNGINKGGARFGLSTEANGAKPQSVWIERTVDLPAGTKYVAFRHYNCSDLNYILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVATGNHEYCVEVKYTAGVSPKVCVNVTINPTQFNPVKNLKAQPDGGDVVLKWEAPSGKRGELLNEDFEGDAIPTGWTALDADGDGNNWDITLNEFTRGERHVLSPLRASNVAISYSSLLQGQEYLPLTPNNFLITPKVEGAKKITYKVGSPGLPQWSHDHYALCISKSGTAAADFEVIFEETMTYTQGGANLTREKDLPAGTKYVAFRHYNCTDVLGIMIDDVVITGEGEGPSYTYTVYRDGTKIQEGLTETTYRDAGMSAQSHEYCVEVKYAAGVSPKVCVDYIPDGVADVTAQKPYTLTVVGKTITVTCQGEAMIYDMNGRRLAAGRNTVVYTAQGGYYAVMVVVDGKSYVEKLAIK
What is the function of this protein?
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position.  Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG.  Disrupts the functions of polymorphonuclear leukocytes.  May act as a virulence factor in the development of peridontal disease.  Involved in the coaggregation of P. gingivalis with other oral bacteria (By similarity).
What are the official names of this protein?
Lys-gingipain 381.
What is the protein family that this protein belongs to?
Belongs to the peptidase C25 family.
What are the subcellular locations of this protein?
[Lys-gingipain catalytic subunit]: Secreted.
Protein: DDL_BACLD
Sequence: MKTRLGLVYGGKSAEHNVSLQTALAVTKALDTEKFDIHPIYITEKGEWVRGPQLTEPVSNVKMLQFEQTGQTFSPAVLNRDMFPGEADAKEDSIDVVFPLLHGPNGEDGTIQGMLELLNVPYVGNGVLASSAGMDKVVMKHLFAQAGLDQAKYVSFLKKTWSQSKEECYAQVEGELGYPCFVKPANLGSSVGISKCRSREELDQAFELAFQYDRKIVVEEGVIGREIELGVLGNDEPVCSVAGEIAPKKDFYDYKAKYEDGDTDLIIPASLTEDEYETMRSMAVKAFQAIDGSGLVRADFFLTNEGRVLINEVNTMPGFTPFSMFPLLWKQSGVEYAELIEKLVALAIERHEEKQQIKHTF
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSAP_XENTR
Sequence: MEAPTLSQLEGLRYSELQKLAKTAGLKANLKADKLLKVLKAHFYPESKNETLDSDGSSSLTDTDELNSSQEKEEPVSVSFVTHRRGRGRKPIRNQDTPKDEFLTVSAGVGTENMASSIDRTQQQNCTESKKEETTSPIIDNKHRKRSRSEDTSKQNNLESTGKTEKRQKKASNVTSVASTGKIPRLAGRLSKPGSKPSTPNFKKLHEAHFKKMESIDKYMERKQKRLDAVSSSIQEVKMLTKKSNLLKSVEKTPVSDIKKPVKSRLSLLSPLPRTTGASPSRTPMSQRRSCRSSTASKSILVDRSGFKPSVFSSSKMNVRFSEATKDNEHKRSLIKTPARKSSSFLAVTPESEPRRILPSVRKTELLPAPEKADKPDVNITLNTTTQPSPATGMSACKAITPFKFTAQNTETPNTKKKGKFDLQASLSRQLGYQPHKGKLKPWGESKENKPDPNSNVSVLKNNYKQPHLQTREDRRNQHVQNRKNKRDQALGTRRGVPVK
What is the function of this protein?
Microtubule-associated protein with the capacity to bundle and stabilize microtubules.  May associate with chromosomes and promote the organization of meiotic or mitotic spindle microtubules around them (By similarity).
What are the official names of this protein?
Nucleolar and spindle-associated protein 1, NuSAP.
What is the protein family that this protein belongs to?
Belongs to the NUSAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Associates with meiotic or mitotic spindle microtubules, particularly in the vicinity of chromosomes.
Protein: DNLJ_VIBC3
Sequence: MSDVAQRLTELRKTLHEHGVRYYVEDAPTIPDAEYDRLMRELLELEAAHPELMSSDSPSLRVGGRPLDAFESVVHEIPMLSLDNAFDDGELESFYRRMTDRIQAVQHSAFCCEPKLDGLAVSLLYENGVLTRAATRGDGMTGENITENVRTIKAIPLRLQGADFPTRLEVRGEVFMPKAGFEALNARALKKGEKQFVNPRNAAAGSLRQLDSKITAQRPLAFYAYSVGVIEGGELATSHYQRFLQLKGWGLPICPETKLVTSLAEVKAFYQDILQRRQFLAYEIDGVVIKVDDIQLQERLGFVARAPRWAIAYKFPAQEELTLLNDVEFQVGRTGAITPVAKLEPVFVGGVTVSNATLHNADEIERLGVMVGDTVVIRRAGDVIPQIVSVVLERRPENAKSIVFPTRCPVCQSDVERVEGEAVARCSGGLICQAQRKEALKHFVSRKAMDVEGLGDKVIEQLVDREMVSTPADLFRLRAGELTILERMGPKSAQNVIDALNKAKQTTLPKFLYALGIREVGDATALNLAQHFLSLEAIQQASLEQFIEVPDVGVVVASHLLAFFAQDRNQQVINELLEQGITWPALTAAPVAVDSALAGKIVVLTGSFTQLSRNDAKAALQALGAKVTGSVSKNTDIVFAGEAAGSKLAKATELGIQVFDEQALIEFLK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: IDIA_SYNE7
Sequence: MSESMFSRRDFLLGGTALAGTLLLDSFGDWRRRAEAAEGEVNLYSGRHYNTDNQIYREFTQKTGIKVNLIEGEADALLARLKSEGSRSPADVFITVDAGRLWQATQANLLRPLTQAQAPKLYQAVPANLRDPQGRWFALSKRARVIMYNRDRVNASQLSTYEDLANPKWRNQILVRSSSNVYNLSLTGEMIAADGAAKTEAWARGLVQNFARQPQGGDTPQILACAAGVGSLAIANTYYLVRLFKSKKAEEREAARKIKVFFPNQKGRGTHVNISGAGIVRTAPNPRAAQLLLEYLLSSQAQAVFARGNGEYPVLRGVSLDPILAGFGQFKESKISASVFGANNAQALQLMDRAGWK
What is the function of this protein?
May also be part of a periplasmic ABC transporter complex involved in iron import.
What are the official names of this protein?
Iron deficiency-induced protein A.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Lumenal side.