PharMolix/UniProtQA huggingface dataset:
Protein: PP4P1_HUMAN
Sequence: MAADGERSPLLSEPIDGGAGGNGLVGPGGSGAGPGGGLTPSAPPYGAAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHARRYGGIYAAWAFVILLAVLCLGRALYWACMKVSHPVQNFS
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287).  Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287).  Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937).  Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770).  May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345).
What are the official names of this protein?
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase, Type 1 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase I, Transmembrane protein 55B.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: SCPB_STAAM
Sequence: MDNHGILESLLFTAGDEGLDEKQLLEILDMSKDQLVELIENYSSHGLMIQRFGTTYVLTTKKEAATYIEQLIEQKSQMKLSQAAMEVLSIIAYNQPLSRSDIELIRSINSDGAVKTLIAKGLVEAKVVNEQRSQQLITTDLFLNVFGISNIEDLPTTEEDDEEMDAFFSNLVNQKGENND
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: DCDA_FRATH
Sequence: MNKYIIFDNTKLLEYIGKNSLITPCYIYDLELLEDTFLNAKKSLDKNFKNAEIHYAIKANHNPKIVGIAKKYGMGIDCVSGGEIKRALEQKVDSQHIVFARFEIELAIDNDIFAFNSESLEEIQVINQIAQRKNKQVNICLRVNPNIDAQTHHYISTGQFDDKFGIAFVDILNWLKDEYRNFANINIIGLHYHVGSQILNYQVFQSLAITTNEHIKLLRQNDINIKHINFGGGLGIDYQNPQQNPIVDFDGYFARFREFFKYSDELVLHFELGRSLVGQSGVLVSQVLFNKVTQGTHFVIIDAGMTELIRPALYQAQHKIAALIDENINQKQHYHIVGPICESSDVFAKYYQLPKLKRGDLLAIYSAGAYGKVLASEYNLRPSVQEYFI
What is the function of this protein?
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
What are the official names of this protein?
Diaminopimelate decarboxylase, DAP decarboxylase, DAPDC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
Protein: ARGB_GEOSE
Sequence: MGKTVVIKCGGSVLDELSPAFFASVNAMRKQGMEVVIVHGGGPEIGQMLKTLRVPSEFVNGLRKTTKDVLAVVEMVLSGKVNKQLASMLRQHGLPAVGVSGVDGGLLEAEPIDLAKLGYVGRVKTVRSQLLRTLLAAGYIPVISPLGIDQNGQTYNINADTAAGAVAAAIGASQLAFVTNVPGILRDGALVAEATAEMIERLIEDGVITGGMIPKVQAALSALSDALPEVMIVSGKTTFYQNGTWHGTTIRKEVGVYL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR18_HORVU
Sequence: MYTSKQPFLKSKQPFSKSKQTFNKSKQPFRKSKQTFRKFKQPFRKSKQPFRRRPRIGPGDRIDYRNMSLINRFISEQGKILSRRINRLTLKQQRLITLAIKQARILSFLPFRNYENEKQFQAQSISIITGSRPRKNRHIPQLTQKYNSNRNLRNYNQNLRNNNRNLSSDC
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AGRA_STAAC
Sequence: MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDPVGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI
What is the function of this protein?
Required for high-level post-exponential phase expression of a series of secreted proteins.
What are the official names of this protein?
Accessory gene regulator A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK36_SPIMX
Sequence: MKVRASVRKICDNCRLIRRRGKVMVVCSNPKHKQCQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SEI1_YEAST
Sequence: MKINVSRPLQFLQWSSYIVVAFLIQLLIILPLSILIYHDFYLRLLPADSSNVVPLNTFNILNGVQFGTKFFQSIKSIPVGTDLPQTIDNGLSQLIPMRDNMEYKLDLNLQLYCQSKTDHLNLDNLLIDVYRGPGPLLGAPGGSNSKDEKIFHTSRPIVCLALTDSMSPQEIEQLGPSRLDVYDEEWLNTIRIEDKISLESSYETISVFLKTEIAQRNLIIHPESGIKFRMNFEQGLRNLMLRKRFLSYIIGISIFHCIICVLFFITGCTAFIFVRKGQEKSKKHS
What is the function of this protein?
Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size (PubMed:18093937, PubMed:18250201).  Facilitates initiation of LD formation, and ensures that vectorial budding of LDs from the ER is directed towards the cytoplasm (PubMed:25540432).
What are the official names of this protein?
Seipin, Few lipid droplets protein 1.
What is the protein family that this protein belongs to?
Belongs to the seipin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Concentrates at endoplasmic reticulum lipid droplet junctions.
Protein: ANMK_VIBVY
Sequence: MSTKELYIGVMSGTSMDGVDCALVEFDQEQVRLIAHSDYPMPADLRQQLLSVCTGQATNLKQIGELDHRLGHLFADAVMDLLSQAGVDASQICAIGNHGQTVFHQPNGEFPFTTQLGDANIIATRTNIDTVADFRRKDMALGGQGAPLVPAFHQSVFALQDSTTVVLNIGGIANISVLHPTRPVLGYDTGPGNMLMDAWCETHTQQNYDKDARFALQGEVNEALLNSLLQEPYLHQDAPKSTGRELFNMEWLTAKLQGQNYRSEDVQRTLCEYTALTISKEVERFRYGPTPQLLVCGGGARNPLLMQRLQQQLSHWQVSTTDAKGVSGDYMEAMAFAWLAYRHMHRLPSNLPEVTGASRLASLGVLYPKA
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: PSTB_OCEIH
Sequence: MSLLTADKKVQVDINKNDKKAPVNNKNIVYDTKDLNLWYGETHALKDINLAINEKEVTAIIGPSGCGKSTYIKTLNRMVELVPTVKTTGTITYRGKNILDRSFKVEDLRTHVGMVFQKPNPFPKSIYENVAYGPKIHGIKNKKVLDEIVEKSLRGASIWDEVKDRLNENAYGLSGGQQQRLCIARCLAIEPNVILMDEPTSALDPKSTLRIEELVQELKKDYSIIIVTHNMQQAARISDKTAFFLNGEVVEFDDTDRIFTKPSDQRTEDYISGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PPK1_MYCUA
Sequence: MIGNDRWVTEIETGPVTEARPDTNAREPGDRTPAAPPAATPAATTDQLPEDRYLNRELSWLEFNARVLALAADDSMPLLERAKFLAVFASNLDEFYMVRVAGLKRRDQMGLSALSADGLTPREQLGRIGEQTQHIASRHARVFRDSVLPALGEEGIYVVTWADLDQAEREQLSTYFHEQVFPVLTPLAVDPAHPFPFVSGLSLNLAVTVRQPEDGGQHFARVKVPDNVDRFVELGGTDTDGAEGAAVHRFLPLEELIAAFLPVLFPGMEIVEHHAFRITRNADFEVEEDRDEDLLQALERELARRRFGSPVRLEVADDMTEGMLELLLRELDVHPGDVIEVPGLLDLSSLWQIYGLDRPALKDRTFVPATHPAFAERETPKSIFATLREGDVLVHHPYYSFSTSVQRFIEQAAADPNVLAIKQTLYRTSGDSPIVRALIDAAEAGKQVVALVEVKARFDEQANIRWARALEQAGVHVAYGIVGLKTHCKTALVVRREGPVIRRYCHIGTGNYNSKTARLYEDVGLLTAAPDIGADLTDLFNSLTGYSRKLSYRNLLVAPHGIRAGIIERVEREVAAHLEHGPQAGKGHIRLKMNALVDEQVTDALYRASQVGVRIEVVVRGICALRPGAEGFSENITARSILGRFLEHSRILHFRAIDEFWIGSADMMHRNLDRRVEVMAQVKDPRLTAQLDDLFESALDPATRCWELGPDGQWTASPQEGRTVRDHQVSLMERHRSP
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: HELI_HHV11
Sequence: MAAAGGERQLDGQKPGPPHLQQPGDRPAVPGRAEAFLNFTSMHGVQPILKRIRELSQQQLDGAQVPHLQWFRDVAALESPAGLPLREFPFAVYLITGNAGSGKSTCVQTINEVLDCVVTGATRIAAQNMYAKLSGAFLSRPINTIFHEFGFRGNHVQAQLGQYPYTLTSNPASLEDLQRRDLTYYWEVILDLTKRALAASGGEELRNEFRALAALERTLGLAEGALTRLAPATHGALPAFTRSNVIVIDEAGLLGRHLLTAVVYCWWMINALYHTPQYAARLRPVLVCVGSPTQTASLESTFEHQKLRCSVRQSENVLTYLICNRTLREYARLSYSWAIFINNKRCVEHEFGNLMKVLEYGLPITEEHMQFVDRFVVPENYITNPANLPGWTRLFSSHKEVSAYMAKLHAYLKVTREGEFVVFTLPVLTFVSVKEFDEYRRLTHQPGLTIEKWLTANASRITNYSQSQDQDAGHMRCEVHSKQQLVVARNDVTYVLNSQIAVTARLRKLVFGFSGTFRAFEAVLRDDSFVKTQGETSVEFAYRFLSRLIFSGLISFYNFLQRPGLDATQRTLAYARMGELTAEILSLRPKSSGVPTQASVMADAGAPGERAFDFKQLGPRDGGPDDFPDDDLDVIFAGLDEQQLDVFYCHYTPGEPETTAAVHTQFALLKRAFLGRFRILQELFGEAFEVAPFSTYVDNVIFRGCEMLTGSPRGGLMSVALQTDNYTLMGYTYARVFAFADELRRRHATANVAELLEEAPLPYVVLRDQHGFMSVVNTNISEFVESIDSTELAMAINADYGISSKLAMTITRSQGLSLDKVAICFTPGNLRLNSAYVAMSRTTSSEFLRMNLNPLRERHERDDVISEHILSALRDPNVVIVY
What is the function of this protein?
Component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs.  Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
What are the official names of this protein?
DNA replication helicase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae helicase family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: TATA_METNO
Sequence: MGGASIWHWIVVGVIVMLLFGRGKVSELMGDVAKGIKAFKKGMADEDQPQAPVANQSPPPVSATEPVRTLPPHQGEPAPAANASVDRKVG
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NAC46_ARATH
Sequence: MVEEGGVVVNQGGDQEVVDLPPGFRFHPTDEEIITHYLKEKVFNIRFTAAAIGQADLNKNEPWDLPKIAKMGEKEFYFFCQRDRKYPTGMRTNRATVSGYWKATGKDKEIFRGKGCLVGMKKTLVFYTGRAPKGEKTNWVMHEYRLDGKYSYHNLPKTARDEWVVCRVFHKNAPSTTITTTKQLSRIDSLDNIDHLLDFSSLPPLIDPGFLGQPGPSFSGARQQHDLKPVLHHPTTAPVDNTYLPTQALNFPYHSVHNSGSDFGYGAGSGNNNKGMIKLEHSLVSVSQETGLSSDVNTTATPEISSYPMMMNPAMMDGSKSACDGLDDLIFWEDLYTS
What is the function of this protein?
Transcriptional activator that acts as positive regulator of leaf senescence.  Activates NYC1, SGR1, SGR2 and PAO, which are genes involved in chlorophyll catabolic processes.  Activates senescence-associated genes, such as RNS1, SAG12 and SAG13.
What are the official names of this protein?
NAC domain-containing protein 46, ANAC046.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL14_LEPBJ
Sequence: MIQQETWLQVADNSGIKKVMCIKVLGGSKKRYASVGDEIIVAVKDAQPAFGLKDSTGKKVHNKAVQRAVVVRTTKEIRRPDGSYIRFDDNACAIIDDKGNPKGTRIFGPVARELRDKKYAKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: NAGB_STAA1
Sequence: MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDNVSTFNLDEYVGLTASHPQSYHYYMDDMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDVLEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTESTIKANSRYFKNEDDVPKQAISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACPKNVAKIHVDEMD
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: SECG_THEGJ
Sequence: MAKDKTTLPPTGAGLMRFFDEDTRAIKVSPKGVIAIVLVLIAFEVFLHLFGPSIFG
What is the function of this protein?
Involved in protein export.  The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
What are the official names of this protein?
Preprotein translocase subunit SecG, Protein transport protein Sec61 subunit beta homolog.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL27_BURO0
Sequence: MAHKKAGGSSRNGRDSESKRLGVKVYGGQAINAGGIIVRQRGTRMHAGENVGMGKDHTLFALVDGHVKFATKGADKKHLVIVVPAAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: Y2116_DICDI
Sequence: MEDFNPTTLNSPKLSRFINYSFISNNNNDKIIFYKYAISEPSYFRRITFRETPIDIDLKFPLNPFQGIFFKNPSIHH
What are the official names of this protein?
Putative uncharacterized protein DDB_G0293776.
Protein: THTR_SACER
Sequence: MSREEVLVSTDWAEQNLNTDGVVFAEVDEDTTAYDGGHIPGAIKLDWKNELQDHVRRDFVNREGFEKLLSAKGIGNDDTVILYGGNNNWFAAYAYWYFKLYGHSDVKLLDGGRKKWELDGRELTKEEPNRAATAYKAQEPDASIRAFRDEVVDAIGNKNLVDVRSPDEFAGKLLAPAHLPQESAQRAGHIPSAINVPWSKAANEDGTFKSDEELKQVYGEAGLDTDKDTIAYCRIGERSSHTWFVLRELLGHTNVKNYDGSWTEYGSLVGVPIENPQEQGA
What is the function of this protein?
May be a sulfotransferase involved in the formation of thiosulfate.
What are the official names of this protein?
Putative thiosulfate sulfurtransferase, Rhodanese-like protein.
Protein: DAPF_THEFY
Sequence: MRFAKGHGTENDFVILPDPDGELDLDAATVAALCDRRAGLGADGVLRVVRTKALDEPLTGEAATAQRCEWFMDYRNADGSVAEMCGNGVRVFARYLQEAGLVGAAAFEVGTRAGARHVVLEPDGNITVDMGPVRILGPGSARLADGPVHGTRISVGNPHLACRVARPVAEVDLSAPPLLRAEEFPQGANVEVFREVASGVLEMRVYERGAAETRSCGTGIVAAAAAATPPGEDARWTVRVPGGECTVVLESGAARLSGPAVIVAEGDVRLSALR
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_GLOVI
Sequence: MNDITAAASVIAAALAVGLAAIGPGIGQGNAASKAAEGIARQPEAEGKIRGTLLLSLAFMESLTIYGLLVSIVLLFANPFRG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MODE_HAEIN
Sequence: MKNTEILLTIKLQQALFIDPKRVRLLKEIQQCGSINQAAKNAKVSYKSAWDHLEAMNKISPRPLLERNTGGKNGGGTALTTYAERLLQLYDLLERTQEHAFHILQDESVPLDSLLTATARFSLQSSARNQFFGRVAQQRIIDSRCVVDVNVQGLPTPLQVSITTKSSARLKLITEKEVMLMFKAPWVKISEQPLANQPNQFPVNIKSLNEEEAILQFAESNIEFCATVHQPNQWQIEQQVWIHIDQEQIILATLG
What is the function of this protein?
The ModE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate.  Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo.  The protein dimer is then competent to bind a DNA region, upstream of the modABC operon.  Acts also as an enhancer of the expression of genes coding for molybdoenzymes, both directly and indirectly (By similarity).
What are the official names of this protein?
Transcriptional regulator ModE.
What is the protein family that this protein belongs to?
Belongs to the ModE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_CAIMO
Sequence: MANHSQLGFQDASSPIMEELVEFHDHALIVALAICSLVLYLLAHMLMEKLSSNAVDAQEVELIWTILPAIVLVLLALPSLQILYMMDEIDEPDLTLKAIGHQWYWSYEYTDFKDLSFDSYMIPTTDLPNGHFRLLEVDHRVVVPMESPIRVIITAGDVLHSWAVPTLGVKTDAIPGRLNQTSFIATRPGVFYGQCSEICGANHSYMPIVVESTPLPYFETWSSLLSAS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BIOF_CUPPJ
Sequence: MLLEQLRRAADERQARALTRRRRIAHTACAPHQAVGPVDAPAPQPLLTFCSNDYMGLASHPDVVAALADGARLYGAGSGASHLVSGHSLAHARLEEELARWFAPHIPQARTLYFCTGYMANMAVLTALGTAGATLFCETLNHASLIDGARLARADVQRYPHCDAAALDALLAASTSPLKLIVTDSVFSMDGDVAPLAELLALAERHDAWIIVDDAHGFGVLGDDGHGVLQALGLNSERFIYIGTLGKAAGVAGAFVAAHETIIEHLVNTARPYIYTTAAPPAVAHALMASLAIIEGEEGRQRRANLNQLIADLRAGLAPLAAAAGWELGDSATAVQPLIVGDNAVSLALSARLEAEGIRVGAIRPPTVPEGTARLRITLSATHTAADVQRLVGVLADAVPPEAKREAA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: CDC62_METMA
Sequence: MTGNDILLWDETLFKDLSVLEPDYLPEYFPHRDSQLNALRFALKPALRGMRPLNCLLVGPPGTGKTSAIMKTFREVEAHAPNVVTVKVNCQIDSTRFAVMSRIYRQLFGISPPNSGIAFRKLFETVVNFLVSSEKVLIVALDDLNYLCCEGHANEVMYSLLRAHEQYPGAKIGVIGIVNDASDLYCLDSRVNSVFLPEEVSFPRYEEGEILDILKDRVRYGFYPKVISDEVLKLVVSYVEKTGDLRVGIDLLRRSGFNAERKGRRMILFEDVEKAYEASKLLHLCRGISLLSDPEKQLLELIAKKDEIKAGELYKSFHELTQLGYTRFYGMVNRLQTLNYVDADFTGKGKRGRTRIIKTKYEAEDILNCLKKA
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein 2.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: COLE_ZOPAT
Sequence: SLQGGAPNFPQPSQQNGGWQVSPDLGRDDKGNTRGQIEIQNKGKDHDFNAGWGKVIRGPNKAKPTWHVGGTYRR
What is the function of this protein?
Responsible for the anti Gram-negative activity of immune hemolymph of Z. atratus.
What are the official names of this protein?
Coleoptericin.
What is the protein family that this protein belongs to?
Belongs to the coleoptericin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y3078_ENTFA
Sequence: MLMFTEKEFAAFEVAGLDERMAVIRAQIQPIFQELDTYFAEQLAPELGTELFVHIAQHRRRTVYPPENTWSALSPNKRGYKMQPHFQLGIWGDYVFMWLSFIDNPKNEKQIAQAFLENQQLFQALPEDTYVSLDHTVPQITPLPETDLEKALTRFRDVKKGEFEIGRIIPKDSDLWQNPEKARAYMLATYQQLLPLYQLAVAQ
What are the official names of this protein?
UPF0637 protein EF_3078.
What is the protein family that this protein belongs to?
Belongs to the UPF0637 family.
Protein: PYRE_PHEZH
Sequence: MNTEDVLNEFRGAGALREGHFVLSSGLHSPVFLQKNLVFQYPDRTERLCKALAAKITEAVGPVDLCVSPAVGGIIPGYETARHLGCPSVYVEREGGEFKLRRAFSIPEGARIAMVEDIVTTGLSSRECVEAIRKAGGNVVVAACIVDRSGGRADPGAPLVALARLDVPAYPADQLPPELAAIPIEDPGSRRLKG
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: NOL11_HUMAN
Sequence: MAALEEEFTLSSVVLSAGPEGLLGVEQSDKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFVVFRHPVLIFITEKHGNYFAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLLERCKAEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQETDVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNKKPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLYFLYLKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVVMMPEAKRLLINLYKLVKSQISVYSELNKIEVSFRELQKLNQEKNNRGLYSIEVLELF
What is the function of this protein?
Ribosome biogenesis factor.  May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.
What are the official names of this protein?
Nucleolar protein 11.