PharMolix/UniProtQA huggingface dataset:
Protein: CDK19_MOUSE
Sequence: MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQPQQQNPHQQPAAPAQQTAAPPQAPPPQQSSAQTNGTAGGATAGGGGAGAGLQHSQDPGLNQVPPNKKPRIGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSQQSTQYHSSHQTHRY
What are the official names of this protein?
Cyclin-dependent kinase 19, CDC2-related protein kinase 6, Cell division cycle 2-like protein kinase 6, Cell division protein kinase 19.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
Protein: ARGB_ERYLH
Sequence: MTATEKTELAKAEVLIEALPYFQRYAGRTFVVKYGGHAMGDPKAAREFAEDIVLLKAVGINPVVVHGGGPQIGAMLKRLGVESTFVDGLRVTDKATAEVAEMVLSGAINKELVGWIAQAGGKAMGVSGKDGSLVTATKLERTTRDPESQIEQILDLGFVGEPTHVDTTILDTAVSAGMIPVVAPIGAGEDGHTYNINADTMAGAIAAALGAARLFLLTAVKGVLDKQGGLLTDLTPAQIAKLKDDGTISGGMIPKLDTCVHAVEAGCEAAVVLDGRVPHAMLLEFFTARGAGTLIRADD
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBD_EMIHU
Sequence: MTIAIGQKQDRGVFDLIDDWLKRDRFVFVGWSGLLLFPCAFLAVGGWLTGITFVTSWYTHGLASSFLEGCNFLTAAVSTPANSMGHSLLLLWGPEAQGDITRWFQIGGLWTFVALHGSFGVIGFCLRQFEIARLVGIRPYNAIAFSGPIAVFVTVFLVYPLGQASWFFAPSFGVAAIFRFLLFLQGFHNWTLNPFHMMGVAGILGGALLCAIHGATVENTLFEDGDAANTFRAFTPTQSEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVAGMWTSAIGIVGLALNLRAYDFVSQELRAAEDPEFETFYTKNNLLNEGIRSWMAAQDQPHENFIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: M4A8_MOUSE
Sequence: MNRPTAQGAVNLSGSKFSTAKSWEPEQERLTWQPGTVSMNTVTSPGPMANSVYVVAPPNSYPVVPGTVPQMPIYPSNQPQVHVISGHLPGLVPAMTEPPAQRVLKKGQVLGAIQILIGLVHIGLGSIMITNLFSHYTPVSLYGGFPFWGGIWFIISGSLSVAAETQPNSPCLLNGSVGLNIFSAICSAVGIMLFITDISISSGYIYPSYYPYQENLGVRTGVAISSVLLIFCLLELSIASVSSHFGCQVACCHYNNPGVVIPNVYAANPVVIPEPPNPIPSYSEVVQDSR
What is the function of this protein?
May be involved in signal transduction as a component of a multimeric receptor complex.
What are the official names of this protein?
Membrane-spanning 4-domains subfamily A member 8, CD20 antigen-like 5, Membrane-spanning 4-domains subfamily A member 8A.
What is the protein family that this protein belongs to?
Belongs to the MS4A family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y239_PYRFU
Sequence: MIVEVVVMTNIEERINQIIQVLREQVVQDTAVPRNIRRAAEQAIEALQNKEKEPAVRAADAIAILEEISEDPNMPLHTRTIIWEVLGALEQIK
What are the official names of this protein?
UPF0147 protein PF0239.
What is the protein family that this protein belongs to?
Belongs to the UPF0147 family.
Protein: UCRI_CHLTE
Sequence: MAQTGNFKSPARMSSLGQGAAPASAGAVTGGKPREEGLKGVDFERRGFLQKIVGGVGAVVAVSTLYPVVRYIVPPAKKIKIVNELAVGPASDVPNGTGKIYQFNDDKVIVVNHGGSLTAVSAICTHLGCLVHWDEAADMIACPCHGAKYTQDGKIISGPQPLPLKQYKVKIEDGKIVVSIA
What is the function of this protein?
Component of the green S-bacteria bc-complex which consists of the Rieske protein and cytochrome b subunit and which appears to lack a cytochrome c1-equivalent.  This complex has a comparatively low redox potential.
What are the official names of this protein?
Cytochrome b6-f complex iron-sulfur subunit, Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein, Rieske iron-sulfur protein, ISP, RISP.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YCF21_ANTSP
Sequence: MNIQLIKNFNPILKINTQSSNIKLNKIIPNEWLFILMNTGSFTQNLNSLLISDININISQKYNYNQPQQFHNTRTVWLANNNNQRFAFAQSRWIIKNNYTNYLNLLNNKPIGKSFIINETDLHKKIEEIYCGHSYILEKNFQSQQLIWGRKYTLLYNKKSFIVIQEYFSPNLTKFLKFH
What are the official names of this protein?
Uncharacterized protein ycf21.
What is the protein family that this protein belongs to?
Belongs to the ycf21 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: H3_CRYNJ
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKQAPSQVSGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDLQLARRLRGERS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
What are the official names of this protein?
Histone H3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: AG_TOBAC
Sequence: MDFQSDLTREISPQRKLGRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALIVFSSRGRLYEYANNSVKATIERYKKACSDSSNTGSISEANAQYYQQEASKLRAQIGNLQNQNRNMLGESLAALSLRDLKNLEQKIEKGISKIRSKKNELLFAEIEYMQKREIDLHNNNQYLRAKIAETERAQQQQQQQQMNLMPGSSSYELVPPPHQFDTRNYLQVNGLQTNNHYTRQDQPSLQLV
What is the function of this protein?
Probable transcription factor involved in regulating genes that determines stamen and carpel development in wild-type flowers.
What are the official names of this protein?
Floral homeotic protein AGAMOUS, NAG1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS8_SOLUE
Sequence: MTSDPIADMLTRVRNAIQARHPKVDVPASKLKAEIARILKEEGYITNFKVAEEGAKKTIKIYLKYANNNSPVISAIERVSRPGCRVYVGQTDIPRVLGGMGINILTTPRGVMTGRDAHKEHLGGEILCRVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NU2M_METNU
Sequence: MSPYVLTIMSLSLLLGTTMTLISDHWLTAWMGLEINTLAVIPLMTKPHHSRSTESAIKYFMIQATASMIILFSAIFNASTTNQWITGQISNTSASFMMTIALAMKLGLAPFHFWVPEVTQGIPLLSGMILLTWQKIAPISIFYQISPSLNMSLLMILSITSTLLGGWGGLNQTQLRKILAYSSIAHMGWMTIIIMIYPSLTILNLILYLASTITMFMVLNQSSSTKINSLSILWNKSAPNMIIITLTLLSLGGLPPLTGFMPKWLILQELINFNNIPLAMMLALSTLLNLFFYMRIIYSSTLTMFPSINNTKLQWALYSHKTILPIPTLTIISSLLLPMTPMFITLS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y1515_ARATH
Sequence: MATRGSRSEKVKRIFQQFDGNHDGGLNREEMAALVVAVNPRVKFSDEQINAILDEVFRTYAEFIDPNKGLTYDGLLRTYDDGAGDVDRDFDALGLELNADETTIKGSEAASSSSITDERAVEAQKKQRTAAWAVSPNHGIVFDETWKLVDDLEILVKRLKSKQEKDGKLKADNNNNNVDAFSDAGWSRELGPSSEISEKRIYWEESSHDYGVFVKELGVLRSKADGARSREEAFDGHMAIGRVLYEHQLFKEALVSFKRACELQPTDVRPHFKAGNCLYVLGKCKESKDEFLLALEAAESGGNQWAYLLPQIYVNLGIALEGEGMVLSACEYYREAAILCPTHFRALKLLGSALFGVGEYRAAVKALEEAIYLKPDYADAHCDLASSLHSMGEDERAIEVFQRAIDLKPGHVDALYNLGGLYMDLGRFQRASEMYTRVLTVWPNHWRAQLNKAVSLLGAGETEEAKRALKEALKLTNRVELHDAISHLKHLQKKKGKNNGNGNGGEGPFIVVEPSKFKTVGEKTTLRPDLATALQIRAFQRVTRLGKCDVEAVRKEMRDNDVPVSYSGSGGPTKSIRKPNLEEILRRLLSSLKPDTFQGAIKAINEKILALLDDSGSGRVDMGMFYAVIAPLCGGHSDKRKRVAFDALLWRPVNEGSSQITKTDAVKYIKLLRAIYIPSHGMSEMLEVHGEEEAESSVTVTFNQFLAMFDDPDWGFGIMSTILKLEANDRNRHGNQVCSVCRYPVIGSRFKEVKARFSLCNQCYGEGKVPPSFKQEEYKFREYESEAEAMKAKCVCFSMQSHKKAIAT
What are the official names of this protein?
Uncharacterized TPR repeat-containing protein At1g05150.
Protein: UGE4_ARATH
Sequence: MVGNILVTGGAGYIGSHTVLQLLLGGYNTVVIDNLDNSSLVSIQRVKDLAGDHGQNLTVHQVDLRDKPALEKVFSETKFDAVMHFAGLKAVGESVAKPLLYYNNNLIATITLLEVMAAHGCKKLVFSSSATVYGWPKEVPCTEESPLSGMSPYGRTKLFIEDICRDVQRGDPEWRIIMLRYFNPVGAHPSGRIGEDPCGTPNNLMPYVQQVVVGRLPNLKIYGTDYTTKDGTGVRDYIHVVDLADGHICALQKLDDTEIGCEVYNLGTGKGTTVLEMVDAFEKASGMKIPLVKVGRRPGDAETVYASTEKAERELNWKANFGIEEMCRDQWNWASNNPFGYGSSPNST
What is the function of this protein?
Catalyzes the interconversion between UDP-glucose and UDP-galactose.  Involved in channeling UDP-D-galactose (UDP-D-Gal) into cell wall polymers.  Required for the galactosylation of xyloglucan (XyG) and type II arabinogalactan (AGII).  Cooperates with UGE2 in cell wall carbohydrate biosynthesis and growth.
What are the official names of this protein?
UDP-glucose 4-epimerase 4, AtUGE4, Protein ROOT EPIDERMAL BULGER 1, Protein ROOT HAIR DEFECTIVE 1, UDP-galactose 4-epimerase 4.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus, Golgi stack.
Protein: DLTC_LISIN
Sequence: MAFRENVLEILEEITETDEVVQNTNIKLFDEGLLDSMATVQLLIEIESRLDITVPVSEFDRDEWATPEMIITQLEALK
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_FRAT1
Sequence: MLDAKYIKDNLQQVAEKLATRGYQFDIAEFEAQEQKRKHLQERTQDLQSQRNTISKEIGQKKAKGEDTSDIFAKVNQINEELKIIEKELKDLQDTINQTLLSMPNLPADDVPVGKDENDNVEIRRWGTPREFHPEAPAKDHSDIGEILKMIDFKAAAKVTGSRFMVLKNKIAKLHRALSQFMLDLHTEKHGYEELYVPYLVNNDSLYGTGQLPKFAADLFKLEGDFEYSLIPTAEVPITNLVRDEILDTETLPRYYTAHTPCFRSEAGSYGRDTKGMIRQHQFEKVELVHITTADKGEESLELLTSHAEKVLQKLNLPYRVMKLCTGDMGFSAKKTYDLEVWLPSQNTYREISSCSWCGDFQARRMKARHKNPSMKKPELVHTLNGSGLAVGRTLLAIIENYQQEDGSIMVPDALIKYMGGISVIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO3_HALS3
Sequence: MSSQDFDVEFVDRDDREARFVVRNITPAFANGIRRAILVDVPTLSIDTVRFVENSSVMFDEQLGLRLGLVPLTTPEDYAAGEAVTLALDVEGPGTAYSGDLVSNDPEVEAADENIPIIELKDDQRLELEADAVMGHGRDHAKHQGGVAVGYRHLQRVHVVGDSPEYADDDPQMLRGVIEEDDELVPTDDFDNDLTTRYPGKEVEIEDVDGAFVFHVESDGSMPVEELVLRAVDTLVDRADELEQAVQL
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo3, DNA-directed RNA polymerase subunit D.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2573_STAAR
Sequence: MIHSKRLKMCLCLIILSVFIGACGMKKEESSKDKQIKENFNKTLSLYPTKNLEDFYDKEGFRDEEFDKGDKGTWIVDSEMVVELKDKKMESRSMVLYINRNTRTTKGNFIVRELWEDSKGYAQSKDTKYPVKMEHNRIIPTKQIADDKLRKEIENFKFFVQYGDFKDINDYKDGDISYNPNVPSYSAEYQLSNNDYNVKQLRKRYNIPTKKAPKLLIKGDGDLKGSSIGHKNLEFTFVENKEENIYFTDSINFKPTE
What are the official names of this protein?
Uncharacterized lipoprotein SAR2573.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ATPD_COXBN
Sequence: MALHLTLARPYAKAAFADGQKANQLEAWLAVFTAFSKIIKNKEVARQIINPKFSDKEIKTLLFDLIQTIEPESTKQLKDKIDHFLQLLIDEKRLMILPDIALVYQQLLNKYQDIIEASVTYVFPLNDEHRQQIQKQLEKRFNAEVKLKMIKDESLLGGVIIRAGNWVMDGSIKGKLTRLAENLKG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RK14_CICAR
Sequence: MIQPQTYLNVADNSGARELMCIRIIGASNRRYAYIGDIIVAVIKKAVPNTPFERSEVIRAVIVRTCKELKRSNGIIIKYDDNAAVVIDKEGNPKGTRIFCAIARELRQLNFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL36_PSEA8
Sequence: MKVLASLKQAKLRHRDCQVVKRRGRLYVICKSNPRFKCVQGRPKPKIKRR
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: HIS1_MANSM
Sequence: MSTNKRLRIAMQKKGRLSDESQELLKQCGVKINLQGQKLIAYAENLPIDILRVRDDDIPGLVFDGVVDLGIIGENVLEEEELTRTAAGDKVEYKMLRRLEFGGCRLSLAVDSDVEFDGPESLSDCRIATSYPQLLKRYMAEQGVPFKSILLNGSVEVAPRAGLADAICDLVSSGATLEANGLKEVEVIYRSKACLIQRKEPLSEEKQALVDKILTRIQGVQQADESKYIMLHAPKDKLEEITALLPGVENPTILPLAHDDTKVAVHVVSQENLFWETMEQLKEKGASSVLVLPIEKMLA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 14331_SOLTU
Sequence: MADSREENVYMAKLAEQAERYEEMVEFMEKVAKVDVEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEDHVSSIKEYRVKIEAELSKICDGILSLLESHLVPSASTAESKVFYLKMKGDYHRYLAEFKTGARERKEAAENTLLAYKSAQDIALAELTPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDDAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDTTDDAEDEIREGSKQESGDGQQ
What are the official names of this protein?
14-3-3-like protein.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: RLMN_MYCTA
Sequence: MVPELMFDEPRPGRPPRHLADLDAAGRASAVAELGLPAFRAKQLAHQYYGRLIADPRQMTDLPAAVRDRIAGAMFPNLLTASADITCDAGQTRKTLWRAVDGTMFESVLMRYPRRNTVCISSQAGCGMACPFCATGQGGLTRNLSTAEILEQVRAGAAALRDDFGDRLSNVVFMGMGEPLANYARVLAAVQRITARPPSGFGISARAVTVSTVGLAPAIRNLADARLGVTLALSLHAPDDGLRDTLVPVNNRWRISEALDAARYYANVTGRRVSIEYALIRDVNDQPWRADLLGKRLHRVLGPLAHVNLIPLNPTPGSDWDASPKPVEREFVKRVRAKGVSCTVRDTRGREISAACGQLAAVGG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMP2_MOUSE
Sequence: MVAGTRCLLVLLLPQVLLGGAAGLIPELGRKKFAAASSRPLSRPSEDVLSEFELRLLSMFGLKQRPTPSKDVVVPPYMLDLYRRHSGQPGAPAPDHRLERAASRANTVRSFHHEEAVEELPEMSGKTARRFFFNLSSVPSDEFLTSAELQIFREQIQEALGNSSFQHRINIYEIIKPAAANLKFPVTRLLDTRLVNQNTSQWESFDVTPAVMRWTTQGHTNHGFVVEVAHLEENPGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
What is the function of this protein?
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis.  Induces cartilage and bone formation.  Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2.  Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A.  In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.  Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation.  Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation.
What are the official names of this protein?
Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: COMP_MOUSE
Sequence: MGPTACVLVLALAILRATGQGQIPLGGDLAPQMLRELQETNAALQDVRELLRQQVKEITFLKNTVMECDACGMQPARTPGLSVRPVPLCAPGSCFPGVVCSETATGARCGPCPPGYTGNGSHCTDVNECNAHPCFPRVRCINTSPGFHCEACPPGFSGPTHEGVGLTFAKSNKQVCTDINECETGQHNCVPNSVCVNTRGSFQCGPCQPGFVGDQTSGCQRRGQHFCPDGSPSPCHEKANCVLERDGSRSCVCAVGWAGNGLLCGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEQDNCPLVRNPDQRNSDSDKWGDACDNCRSKKNDDQKDTDLDGRGDACDDDIDGDRIRNVADNCPRVPNFDQSDSDGDGVGDACDNCPQKDNPDQRDVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQQDSDHDGKGDACDDDDDNDGVPDSRDNCRLVPNPGQEDNDRDGVGDACQGDFDADKVIDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTAMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYESHRLQRV
What is the function of this protein?
Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin (PubMed:32686688).  Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors.  Could play a role in the pathogenesis of osteoarthritis.  Potent suppressor of apoptosis in both primary chondrocytes and transformed cells.  Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity).  Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli.  Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
What are the official names of this protein?
Cartilage oligomeric matrix protein, COMP.
What is the protein family that this protein belongs to?
Belongs to the thrombospondin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: HSLO_STRZJ
Sequence: MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGRTLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATGEVLVGPFVGNGQFLVITDYGAGNPYNSITPLISGEIGEDLAFYLTESQQTPSAVGLNVLLDEEDKVKVAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIYGDEAYKRLSEEEIRFQCDCSHERFMNALASLPSSDLQEMKEEDHGVEITCQFCQTTYNFDEKDLEELIRDKS
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCJ14_RAT
Sequence: MGLARALRRLSGALEPGNSRAGDEEEAGAGLCRNGWAPGPVAGNRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLTFWLIASLHGDLAAPPPPAPCFSQVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDRRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFHRTYEVPGTPVCSAKELDERAEQASHSPKSSFPGSLAAFCYENELALSCCQEEDEEEDTKEGTSAETPDRAASPQALTPTLALTLPP
What is the function of this protein?
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.  KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium.
What are the official names of this protein?
ATP-sensitive inward rectifier potassium channel 14, Inward rectifier K(+) channel Kir2.4, IRK-4, Potassium channel, inwardly rectifying subfamily J member 14.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.