PharMolix/UniProtQA huggingface dataset:
Protein: NRF1_MOUSE
Sequence: MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATTTHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANGLVQIPVSMYQTVVTSLAQGNGPVQVAMAPVTTRISDSAVTMDGQAVEVVTLEQ
What is the function of this protein?
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene.  Links the transcriptional modulation of key metabolic genes to cellular growth and development.  Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity).
What are the official names of this protein?
Nuclear respiratory factor 1, NRF-1, Alpha palindromic-binding protein, Alpha-pal.
What is the protein family that this protein belongs to?
Belongs to the NRF1/Ewg family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MBD2_MOUSE
Sequence: MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAARGGGVCGRGRGRGRGRGRGRGRGRGRGRPQSGGSGLGGDGGGGAGGCGGGSGGGVAPRRDPVPFPSGSSGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNAVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKFTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEVDIDMDSGDEA
What is the function of this protein?
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669).  Binds hemimethylated DNA as well (By similarity).  Recruits histone deacetylases and DNA methyltransferases to chromatin (By similarity).  Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity).  Acts as transcriptional repressor and plays a role in gene silencing (By similarity).  Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity).  May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity).  Selectively represses transcription activity of methylated rRNA promoters (PubMed:14610093).
What are the official names of this protein?
Methyl-CpG-binding domain protein 2, Methyl-CpG-binding protein MBD2.
What are the subcellular locations of this protein?
Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
Protein: NADD_SHEB8
Sequence: MRIGILGGTFDPIHYGHIRPAIEVKHALALDKILLMPNHIPPHKHQPNLTTAQRLKMVADVCSQLDGFELCDIEAKRDTPSYTVVTLEQLKSLHPEHELFFIMGMDSFLQLKSWYEWQRLFDFAHLVVCQRPGWQLDAAHPMQQILTARSHAHQETHEGHAKNTHKNSGQIFPVTITPQDISSTQIREQLAKGEIPADLLMPITLDYIQNQRLYLP
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: RNH2_SHEHH
Sequence: MAVIKGITPEQVAQICIGHYAGVDEVGRGPLIGNVVTAAVILDPNNPIEGLNDSKKLSEKKRELLFEQIQQKALSVSVGSATPAEIDELNILHATMLAMQRAVAGLNIKPTSVLVDGNRTPDFGVESHAIIKGDGLIDAISAASIIAKVVRDREMDALALQYPEYGFDKHKGYPTKAHFEALTQHGVLPEHRKSFRPVREALA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_STAMF
Sequence: MVKAPRGYRHRTRKVFSKHIREKGAVPPLSLLMIDYKPGDKVHIVVNPAIHKGMPHRRYHGKTGTIIGKRGKAYIVKITLGDKEKTLFIRPEHLRPAKA
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: PMA3_ARATH
Sequence: MASGLEDIVNENVDLEKIPIEEVFQQLKCSREGLSGAEGENRLQIFGPNKLEEKKESKLLKFLGFMWNPLSWVMEAAAIMAIALANGGGKPPDWQDFVGIVCLLVINSTISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQVGHFQKVLTAIGNFCICSIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIEVYCKGVEKDEVLLFAARASRVENQDAIDAAMVGMLADPKEARAGIREIHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILDLCNARADLRKRVHSTIDKYAERGLRSLAVSRQTVPEKTKESSGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSNMYPSSSLLGKHKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLIALIWKFDFSPFMVLIIAILNDGTIMTISKDRVKPSPTPDSWKLKEIFATGVVLGGYMAIMTVVFFWAAYKTDFFPRTFHVRDLRGSEHEMMSALYLQVSIVSQALIFVTRSRSWSFTERPGYFLLIAFWVAQLIATAIAVYGNWEFARIKGIGWGWAGVIWLYSIVFYFPLDIMKFAIRYILAGTAWKNIIDNRTAFTTKQNYGIEEREAQWAHAQRTLHGLQNTETANVVPERGGYRELSEIANQAKRRAEIARLRELHTLKGHVESVVKLKGLDIETAGHYTV
What is the function of this protein?
The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport.  The resulting external acidification and/or internal alkinization may mediate growth responses.
What are the official names of this protein?
ATPase 3, plasma membrane-type, Proton pump 3.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRHO_BRUSI
Sequence: MSNLPFTVAALYCFAPLPQYESLREPLAQLCCANGIKGTLLLAAEGINGTVAGSAGAIEKLIAHITAIPGLGEPELKYSHASEMPFHRMKVRLKREIVTMGVEGIDPLKSVGTYIVPKDWNALIADENTVVVDTRNDYEYAIGTFEGAIDPQTRTFRAFPEWVKQNRDRLEGKKIAMFCTGGIRCEKATAFVKGLGFDDVYHLKGGILKYLEEVPREQSMWNGECFVFDERVAVGHGLAESDVELCRACRRPLTPQDKLSQFFEEGVSCAGCYAERTPEDRARYAERQKQVKLAEKRGANKHIGS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: AROA_THEMA
Sequence: MLSVPPDKSITHRALILSALAETESTLYNLLRCLDTERTHDILEKLGTRFEGDWEKMKVFPKPFAEPIEPLFCGNSGTTTRLMSGVLASYEMFTVLYGDPSLSRRPMRRVIEPLEMMGARFMARQNNYLPMAIKGNHLSGISYKTPVASAQVKSAVLLAGLRASGRTIVIEPAKSRDHTERMLKNLGVPVEVEGTRVVLEPATFRGFTMKVPGDISSAAFFVVLGAIHPNARITVTDVGLNPTRTGLLEVMKLMGANLEWEITEENLEPIGTVRVETSPNLKGVVVPEHLVPLMIDELPLVALLGVFAEGETVVRNAEELRKKESDRIRVLVENFKRLGVEIEEFKDGFKIVGKQSIKGGSVDPEGDHRMAMLFSIAGLVSEEGVDVKDHECVAVSFPNFYELLERVVIS
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRC8C_RAT
Sequence: MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQTVINTTPLPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSNTIQSGPEGSLVKSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDALFETLPSDVREQMKAD
What is the function of this protein?
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202).  The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity).  Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity).  The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity).  Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202).
What are the official names of this protein?
Volume-regulated anion channel subunit LRRC8C, Leucine-rich repeat-containing protein 8C.
What is the protein family that this protein belongs to?
Belongs to the LRRC8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane.
Protein: RL18_ROSDO
Sequence: MANSKRQLFIKRRLRVRNKLRKVNAGRVRLSVHRSNKNISVQLIDDVAGKTLASASTLEKDLGVVGKNNIEAAAKVGAAIAERAKKAGVSEAYFDRGGFLFHGKVKAVAEAAREGGLKI
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ASPD_THEMA
Sequence: MTVLIIGMGNIGKKLVELGNFEKIYAYDRISKDIPGVVRLDEFQVPSDVSTVVECASPEAVKEYSLQILKNPVNYIIISTSAFADEVFRERFFSELKNSPARVFFPSGAIGGLDVLSSIKDFVKNVRIETIKPPKSLGLDLKGKTVVFEGSVEEASKLFPRNINVASTIGLIVGFEKVKVTIVADPAMDHNIHIVRISSAIGNYEFKIENIPSPENPKTSMLTVYSILRTLRNLESKIIFG
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.  Does not show aspartate oxidase activity.  Is also able to catalyze the reverse reaction, i. e.  the reductive amination of oxaloacetate.
What are the official names of this protein?
L-aspartate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: PDXT_GEOSW
Sequence: MMKIGVLGLQGAVQEHVRSIEACGAEAVVVKKIEQLEEIDGLILPGGESTTMRRLMDKYGFIEPLKQFAAAGKPMFGTCAGLILLAKRIVGYDEPHLGLMDITVERNSFGRQRESFEAELSIAGVADDFIGVFIRAPHIVEVGEDVEVLAKYEGRIVAARQGQFLGCSFHPELTDDYRMTQYFLNMVKEAKA
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: Y3443_SHESH
Sequence: MPSMDIVSEVDEVELRNAVENSVRELKSRFDFRGKEASIEYKDHVVTLSAEDDFQCQQLVDILRMQMSKRSVDPASMDVDEKALHSGKTFSLKVRFKEGIETLIAKKLVKMIKDSKLKVQSSIQGDSVRVTGKKRDDLQAVMALARESELGQPFQFNNFRD
What are the official names of this protein?
UPF0234 protein Ssed_3443.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: PYRB_BUCAI
Sequence: MRNSLYKKNIISINDLQRNELELVLNKSAMLKKTPQPNLLKNKVIASCFFEASTRTRLSFETAIYRLGASIVGFSDGNNISLEKKGETLTDTISVISSYVDAIIIRHPQEGSARLAAEFSNKKPIFNAGDGANQHPTQTLLDLFTIQETQNRLTQLNIAIVGDLKYGRTVHSLTQALAKFKHNKFYFISPDALKMPNYINNMLDKKEIYWKRHNNIEEIISEIDILYMTRIQKERLDSTEYANAKSKFVLRAAILKNARNNMKILHPLPRIDEIDRDVDYTPYAWYFKQAANGIYARQAILSLVLIEKHL
What are the official names of this protein?
Aspartate carbamoyltransferase catalytic subunit, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TPCD_ASPFU
Sequence: MDSITQLEARANEVAAAARRLAEYCRNARVDGACLPAVVPSEAPRAIREIQRLLLSNVDHLQILLTEPADLVQRLAVQSQLLSCLQWLGEFQVLACLPLTDTVSIADLARLSGVPEAQLARIIRFTITIGFLQEPQRGHVAHSPLSSLFVSRPSLRDAVMFLADSAAPTALQMASATGRFGDTVASETDTAYNIAFDHRDPFYFACEQRPKLQRRWSAYLQHTGGDARDLTQQVLSRVDWFNLNNACVVEVLGPQSQSVTMMLDQLHPMLHFIVQEARIPNGSTHAALHQDVRSVQIRELGGPQRVRDAAIYILNLGPLPHAILSTSVLTELRAHFSVLAANSCAMLILTAGLLLPKPGAVDARVETSVRLHDLSLLQLANDRLMEEDELVEMVHGVKDSVGRLAVVNRLHLPCTTTVALGVRYQAFGHGDSSAKSL
What is the function of this protein?
Transcriptional coactivator; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process (PubMed:26278536, PubMed:26242966).  With tpcE, coregulates the production of trypacidin (PubMed:26278536, PubMed:26242966).
What are the official names of this protein?
Trypacidin cluster transcriptional coactivator tpcD, Trypacidin synthesis protein D.
What are the subcellular locations of this protein?
Nucleus.
Protein: VP06_OPICY
Sequence: GWGRTIRTHXSIDLNXGE
What are the official names of this protein?
Venom peptide Ocy6.
What are the subcellular locations of this protein?
Secreted.
Protein: PCKA_CHESB
Sequence: MQETGLRNPTNGIETSGLKTSGTVFFNLTEPQLYEEAIRRAEARISAHGALVAETGQHTGRSPKDKFIVRDASTENEIWWDNNKPLSGEHFEALYEDFKRHAESLDLFVQDLVGGADPENALPVRVVTEYAWHSLFIRNLLIRPMRSELKSFVPQMTVIDLPSFRADPKRHGCRTETIIAMDLKRMIVLIGGTSYAGEMKKSVFTALNYLLPAKGVMPMHCSANEGSEGDVAIFFGLSGTGKTTLSAEPSRTLIGDDEHGWGPHGIFNFEGGCYAKTIKLSREAEPEIFATTERFGTVLENVVVDEHGVPDFDDGSRTENTRCAYPLHFISNASETGRAGQPKNVIMLTADAFGVMPPIAKLTPAQAMYHFLSGYTAKVAGTEKGVTEPEATFSTCFGAPFMPRHPSVYGNLLRDLIAEHEVDCWLVNTGWTGGAYGTGHRMPIKVTRALLSAALDGSLRTAQFRTDPNFGFAVPVAVPGVDGTILDPRSTWADKAAYDVQAERLVSMFVANFGKFENHVEADVMNASPQIRQAAE
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_ALKCK
Sequence: MLVNEGIRAREVRLVGANGDQIGVKSKHEALEMAQRVNLDLVCVAPNAKPPVCRIMDYGKYRYEQQKKEKEARKNQKVITIKEVRLSPTIEANDFNTKLRNARKFLEKGDKVKASIRFRGRAITHSQIGRDVLERLAKECEDIATIEARPKMEGRSMFLVMAPKTEK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP2B_EMENI
Sequence: MDRNLARAVADKQPVPEIDFTLHVMEDGTQVSTLERVVKEVQAPALNKPSDDQFWDPEEPTKPNLQFLKQHFYREGRLTEDQALWIIQAGTQILKSEPNLLEMDAPITVCGDVHGQYYDLMKLFEVGGDPAETRYLFLGDYVDRGYFSIECVLYLWALKIWYPNTLWLLRGNHECRHLTDYFTFKLECKHKYSERIYEACIESFCALPLAAVMNKQFLCIHGGLSPELHTLEDIKSIDRFREPPTHGLMCDILWADPLEDFGQEKTGDYFIHNSVRGCSYFFSYPAACAFLEKNNLLSVIRAHEAQDAGYRMYRKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILNTCSKEELEDETPSTISPAEPSPPMPMDTVDTESTEFKRRAIKNKILAIGRLSRVFQVLREESERVTELKTAAGGRLPAGTLMLGAEGIKQAITNFEDARKVDLQNERLPPSHDEVVRRSEEERRIALDRAQHEADNDTGLATVARRISMKIPSTTRR
What is the function of this protein?
Calcium-dependent, calmodulin-stimulated protein phosphatase.  This subunit may have a role in the calmodulin activation of calcineurin.
What are the official names of this protein?
Serine/threonine-protein phosphatase 2B catalytic subunit, Calmodulin-dependent calcineurin A subunit.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-2B subfamily.
Protein: RIBA_ECO24
Sequence: MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: NCPP_SULIN
Sequence: MVTIALGSKNPVKINATKEALDVLKLNWDLIGIEVDSGVDKQPFCDQTYVGARNRALNVIRVTNADIGLGIEGGVCNVYGKFIANAVVYVITKEGLENFAISSSFTLPSSMVSLILQGKELGEASDIIFKTNNSKTKEGAIGLLTNNVINRKMLYVQPIVLALYPIYNTMINNTPF
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Probable inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: TMM89_HUMAN
Sequence: MLHVLASLPLLLLLVTSASTHAWSRPLWYQVGLDLQPWGCQPKSVEGCRGGLSCPGYWLGPGASRIYPVAAVMITTTMLMICRKILQGRRRSQATKGEHPQVTTEPCGPWKRRAPISDHTLLRGVLHMLDALLVHIEGHLRHLATQRQIQIKGTSTQSG
What are the official names of this protein?
Transmembrane protein 89.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RPO1C_SULIM
Sequence: MIDEKDKSYLEEKVKQASNILPQKIVEDLKNLISNKEVLVTRDEIDKIFDLAIKEYSEGLIAPGEAIGIVAAQSVGEPGTQMTLRTFHFAGIRELNVTLGLPRLIEIVDAKKVPSTPMMTIYLTDEYKHDKEKALEVARKLEYTKIENVVSSTSIDIASMSIILQLDNEMLKDKGVTVDDVKKAINRLKLGEFVIDESEGNTLNISFANIDSIAALFKLRDKILNTKIKGIKGIKRAIVQKKGDEYIILTDGSNLSGVLSVKGVDIAKVETNNIREIEEVFGIEAAREIIIREISKVLAEQGLDVDMRHILLVADVMTRTGVVRQIGRHGVTGEKNSVLARAAFEVTVKHLLDAAARGDVEEFKGVVENIIIGHPIKLGTGMVELTMRPILR
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y543_ACTSZ
Sequence: MEMTTTQRLILANQYKLMGLLDPANAKTYARSEAIVRGGFSLELKALDNEFNNLSVEECQTVLDTLEMYKALQVSYNNLTDKAEVTEHRLKFAGYCAVREKKYLNYLRFITGTEGKYQEFMHCEHGCDSQTPMWDKYTKMLDVWRNCPHGYHLSIQEIQKILNA
What are the official names of this protein?
UPF0304 protein Asuc_0543.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: CAPPC_FLATR
Sequence: MANRNLEKLASIDAQLRLLVPGKVSEDDKLIEYDALLLDKFLDILQDLHGEGLKETVQECYELSAEYEGKHDPKKLEELGNVLTSLDPGDSIVIAKAFSHMLNLANLAEEVQIAYRRRIKLKKGDFADEASATTESDIEETFKKLVHKLKKSPEEVFDALKNQTVDLVFTAHPTQSVRRSLLQKHGRIRDCLAQLYAKDITPDDKQELDEALHREIQAAFRTDEIRRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANMYFSQIEDLMFEMSMWRCSDELRVRAEELHRSSSKRDVKHYIEFWKQVPPTEPYRVILGDVRDKLYNTRERARHLLAHDVSDIPEESVYTNVEQFLEPLELCYRSLCACGDRVIADGSLLDFLRQVSTFGLSLVRLDIRQESDRHTDVLDAITQHLEIGSYREWSEEKRQEWLLSELSGKRPLFGPDLPKTEEIADVLDTFHVLAELPADCFGAYIISMATSPSDVLAVELLQRECHVKQPLRVVPLFEKLADLEAAPAAVARLFSIEWYKNRIDGKQEVMIGYSDSGKDAGRLSAAWQLYKAQEELINVAKKFGVKLTMFHGRGGTVGRGGGPTHLAILSQPPETIHGSLRVTVQGEVIEQSFGEEHLCFRTLQRFCAATLEHGMNPPISPRPEWRALMDEMAVYATEQYREIVFKEPRFVEYFRLATPELEYGRMNIGSRPSKRKPSGGIESLRAIPWIFAWTQTRFHLPVWLGFGAAFKYAIEKDIKNLHMLQEMYKTWPFFRVTIDLVEMVFAKGDPGIAALNDKLLVSEDLWSFGESLRANYEETKNLLLKIAGHKDLLEGDPYLRQRLRLRDSYITTLNVCQAYTLKRIRDPNYHVTFRPHISKEYSEPSSKPADEYIKLNPKSEYAPGLEDTLILTMKGIAAGMQNTG
What is the function of this protein?
Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase 2, PEPC 2, PEPCase 2, ppcC.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAAA_METBF
Sequence: MKELKILVVNNYGQFCHLIHRAVRDLDMDTKIIPNTTPIEDILAEEPDGLILSGGPEMDRAGLCFDYVREIDLPILGICLGHQAIALAYGGHVHSGKKGGYAEVEVEVLEEDDILRGLGPKATVWASHADEVAILPEGFIHLARSDICEIEAMRHPTKPIYGVQWHPEVSHTEKGEELLTNFLEICEKY
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit A, Glutamine amidotransferase.
Protein: SURA_SALCH
Sequence: MKNWKTLLLGIAMIANTSFAAPQVVDKVAAIVNNGVVLESDVDGLMQSVKLNAGQAGQQLPDDATLRHQILERLIMDQIILQMGQKMGVKITDEQLDQAIANIAKQNNMTMDQMRSRLAYDGLNYSTYRNQIRKEMIISEVRNNEVRRRITVLPQEVDALAKQIGTQNDASTELNLRHILIALPENPTSEQVNDAQRQAESIVEEARNGADFGKLAITYSADQQALKGGQMGWGRIQELPGIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGQSQSISVTEVHARHILLKPSPIMNDQQARLKLEEIAADIKSGKTTFAAAAKEYSQDPGSANQGGDLGWATPDIFDPAFRDALTKLHKGQISAPVHSSFGWHLIELLDTRKVDKTDAAQKDRAYRMLMNRKFSEEAATWMQEQRASAYVKILSN
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: PRR27_HUMAN
Sequence: MKLLLWACIVCVAFARKRRFPFIGEDDNDDGHPLHPSLNIPYGIRNLPPPLYYRPVNTVPSYPGNTYTDTGLPSYPWILTSPGFPYVYHIRGFPLATQLNVPPLPPRGFPFVPPSRFFSAAAAPAAPPIAAEPAAAAPLTATPVAAEPAAGAPVAAEPAAEAPVGAEPAAEAPVAAEPAAEAPVGVEPAAEEPSPAEPATAKPAAPEPHPSPSLEQANQ
What are the official names of this protein?
Proline-rich protein 27.
What are the subcellular locations of this protein?
Secreted.
Protein: ACKA_FINM2
Sequence: MKVLVINCGSSSLKYQLFDMTDESVLCKGLVERIGIEGSKLTHKVNGEKLVVEEPMKDHTEAINHVFDALLDEKYGVIKSLDEVSAIGHRVLHGGDKLTESCIIDDKVKDKIREFIKFGPLHNPANLMGIEACEKLAPGKKNIAVFDTAFHQTMPAKTFMYAIPYEYYEDYRLRKFGFHGTSHRYITLRTQQLLGKEDINIITVHLGNGSSIAAVKNGKCYDTSMGLTPLEGLLMGTRSGDLDPTVMTFLMNEKGYSADEMNQILNKKSGVLGVSGISSDFRDLEEEAEKGNDRAQLALDMFIERVKRYIGGYMAELGHVDAICFAGGIGENSSSMRKDILDTFEELGVKLDLEKNNTREEALISADDSKVKVYVVPTNEELMIARDTLELAK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.