PharMolix/UniProtQA huggingface dataset:
Protein: ITP1_USTMD
Sequence: MDQADHSGVPDDAALEEAPNTVPIQEKSAQPHDTQPYCAFTKRSKLFIVLTVSLAGFFSPFAINIYIPALPQIAGMLHTSEAATNVTVTVYMIAQGLSPVIWAPLSDVFGRRPIYILTFFIFFIANLGLSFTNVYWLLVVLRMVQAAGACSAIAIGAGTIGDVTERKERGSYMGYYALAQYTGPAIGPVVGGALSQRWDYHATFFFLTAISGPFLLFMLLFLVETLRVIVGNGSAKTSGIYRPLVEPKLQRSIANAPRPGIKNPLHGTLDFGFHRPFLVFARPETSLAILAFSMVYASYYLSSGSLPYLFKQVYGLDELLIGVCFVPSGVGCAVGTVLAGKILDWDYRRALDKSKLGVKVTRARLQSAWIYLPCYCASLLAYGWCVRAHTHIAAPIVFQFTLGMFSTMYFTNVNTLIVDLYPGKAASATAAVNVGRCLLGAVAVAVVQPMIDAMGAGWTFTLGALLTLIVGLICQVLIYLYGEMWAARKHS
What is the function of this protein?
MFS transporter; part of the gene cluster that mediates the biosynthesis of itaconic acid and 2-hydroxyparaconate (PubMed:26639528, PubMed:27750034).  Cis-aconitate is secreted by the mitochondrial tricarboxylate transporter MTT1.  In the cytosol cis-aconitate is converted into trans-aconitate via isomerization by the aconitate-delta-isomerase ADI1 (PubMed:26639528).  Decarboxylation of trans-aconitate by the trans-aconitate decarboxylase TAD1 then leads then to the production of itaconic acid (PubMed:26639528).  The cytochrome P450 monooxygenase CYP3 further converts itaconate to 2-hydroxyparaconate via oxidation of the double bond, leading to a transient epoxide, which can subsequently be lactonized to produce 2-hydroxyparaconate (PubMed:27750034).  Secretion of itaconate and possibly 2-hydroxyparaconate into the medium is mediated by the major facilitator ITP1 (PubMed:26639528, PubMed:27750034).  The glyoxalase domain-containing protein RDO1 is not involved in the biosynthesis of itaconate and 2-hydroxyparaconate, however, it might play a role in the further conversion of 2-hydroxyparaconate to itatartarate (PubMed:27750034).
What are the official names of this protein?
Itaconate transport protein, Itaconic acid/2-hydroxyparaconate biosynthesis cluster protein ITP1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAPP_ECOL5
Sequence: MNEQYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDLYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: KPCD3_MOUSE
Sequence: MSANNSPPSAQKSVFPATVSAVLPAPSPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPECVPLLSEESHTHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYGRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPCSVGTDADMPMDIDSSDVNSDGSRGLDDSEEPSPPEDKMFFLDPTDLDVERDEETVKTISPSTSNNIPLMRVVQSIKHTKRRSSTVVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRVSSPQDFTSISQGSNPHCFEIITDTVVYFVGENNGSSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHNLATSISVSNCQVQENVDISSVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLEYPKHFIMAPNPDDMEEDP
What is the function of this protein?
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC.  Involved in resistance to oxidative stress (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase D3, Protein kinase C nu type, nPKC-nu.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation.
Protein: HCHA_STAAB
Sequence: MSQDVNELSKQPTPDKAEDNAFFPSPYSLSQYTAPKTDFDGVEHKGAYKDGKWKVLMIAAEERYVLLENGKMFSTGNHPVEMLLPLHHLMEAGFDVDVATLSGYPAKLELWAMPTEDEAVITTYNKLKEKLKQPKKLADVIKNELGPDSDYLSVFIPGGHAAVVGISESEDVQKTLDWALENDRFIVTLCHGPAALLSAGLNREKSPLEGYSVCVFPDSLDEGANIEIGYLPGRLKWLVAELLTKQGLKVVNDDMTGRTLKDRKLLTGDSPLASNELGKLAVNEMLNAIQNK
What is the function of this protein?
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals.  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals.  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE).  Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA.  Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair.  Plays an important role in protecting cells from carbonyl stress.
What are the official names of this protein?
Protein/nucleic acid deglycase HchA, Maillard deglycase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family. HchA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUSO_ASPCI
Sequence: MKIPDNPQIQRFPATTPAPTLWKAVADDGVAIVTNAIPIDTIQRFHADIDNTGHATYLEDYKAFKDKEFPVQAKHASNLVRTSPVFRHEILNTPLIHEICTAAFQHLGDYWLTSSIFRSTNPGNPAQDFHRDALFHPLLQYQSPSAPHLTVSLIIPTTPFTKANGATRVILGSHKWENMTPQNIDALSKDDSVHAEMNAGDIMILHQRTIHAGGEHLPEAKDTRRLLLLLFTSCQLAQLESALALPRPLVESLTPLAQKMVGWRTVKPAGVNVVGLNTYHTGTLEDGLGLRSNQTMAG
What is the function of this protein?
Iron/alpha-ketoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
Iron/alpha-ketoglutarate-dependent dioxygenase ausO, Austinoid biosynthesis cluster protein O.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: MVK_SACS2
Sequence: MMVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVKVSENDKFLIISPSLNIKGVKLDLNEMKIESDEAKKVLRYVFEVLNYFEMKKPVKIEINSTVEPSVGLGTSAAVIVGTVAAYSKYLGIDLSRDEIAKISHNIELKVQGIASRMDTYTETYGGLIYFPAGGKGFEKIDTNFELTAGYIRRSMSTADVLWRVRTLKESNKEVFENILDVIGEITNRAKSLIVEQNFEELGLLMYVNHGLLFSLGITSPEADEIVSRAKQLGIKGCKISGGGAGGSIICIKSVEAEVLLRSYNARIVNSTLTKDGVIFSIL
What is the function of this protein?
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP).  Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
What are the official names of this protein?
Mevalonate kinase, MK, MVK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTAA_RICRO
Sequence: MQKSLITKWLCINCIMVIATIVIGGITRLTGSGLSIVEWRPVTGILPPFSFESWQSEFAKYKAFPEYNSVNYGITLSQFKFIYLLEFIHRLLGRITALIYIVPVIYFYFKDVIKNRDMLPYIIALLLFCVQGFIGWYMVKSGLLNSPYVSHFRLAFHLIIAVIIYHILFYQLIKNRCDILLIPSQTDFKLPLIFSGIAITVVYVQIFLGALVAGLDAGLIYNSFPLMDDRFIPMEIKDNFFDLKNWYDPVFIQFIHRLVGYSVFLVVVVLIICLLKIEHPKLNKIAYFLMIALFMQVSTGIITLLYSVPIIIASIHQLFAIILLSVIIWCYFLIKSF
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GAGE5_HUMAN
Sequence: MSWRGRSTYYWPRPRRYVQPPEVIGPMRPEQFSDEVEPATPEEGEPATQRQDPAAAQEGEDEGASAGQGPKPEADSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEEGEKQSQC
What are the official names of this protein?
G antigen 5, GAGE-5, Cancer/testis antigen 4.5, CT4.5.
What is the protein family that this protein belongs to?
Belongs to the GAGE family.
Protein: GVPI2_HALSA
Sequence: MTPTNRHTHGQNAQHARRNAQQSRDAARRKLIAQHAALAEQRARNRRRSDTEQPTSDTTNPAAHSTLPAQRTNAQNAARNAHSTVPEQPTHATTAARARLYGLRLHNTATTDK
What is the function of this protein?
May play a structural or regulatory role in gas vesicle synthesis.
What are the official names of this protein?
Protein GvpI 2.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: NUOI_PSEFL
Sequence: MFKYIGDIVKGTGTQLRSLVMIFGHGFRKRDTLQYPEEPVYLAPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAETEDGRWYPDFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMAEFKRQDLVYEKEDLLISGPGKNPDYNFYRVAGMAIAGKPKGAAQNEAEPINVKSLLP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).  Required for plants roots colonization.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RPOA_BORPA
Sequence: MSTQGFLKPRSIEVEPVGAHHAKIVMEPFERGYGHTLGNALRRILLSSMTGYAPTEVQMTGVVHEYSTIAGVREDVVDILLNLKGVVFKLHNRDEVTLVLRKNGAGAVVASDIELPHDVEIINPDHLICNLTDAGKIEMQVKVEKGRGYVPGNVRALSEDRTHTIGRIVLDASFSPVRRVSYAVESARVEQRTDLDKLVLDIETNGVISPEEAVRQAARILMDQISVFAALEGAGDAYEPPVRGTPQIDPVLLRPVDDLELTVRSANCLKAENIYYIGDLIQRTENELLKTPNLGRKSLNEIKEVLAARGLTLGMKLENWPPLGLERP
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: GALT7_HUMAN
Sequence: MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINKAKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV
What is the function of this protein?
Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide.  In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties.  Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
What are the official names of this protein?
N-acetylgalactosaminyltransferase 7, Polypeptide GalNAc transferase 7, GalNAc-T7, pp-GaNTase 7, Protein-UDP acetylgalactosaminyltransferase 7, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: RPOZ_PROM1
Sequence: MNSNDLAKRGESLIRHSTNRYLTTVRIAFRAKQRRFDDFDGLLEESTVKPVQRAIIELSDEQDQPDLLPG
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: MCTE_CERS4
Sequence: MAHQAHPFRSVLYIPGSKERALEKAQGLAADAIIFDLEDAVAHDEKIHARRLLKTTLETADYGHRFRIVRVNGMDTEWGRADLEAFAEAKADAILIPKVSRAADLEAVAALVPDLPLWAMMETAQGMLNAAEIAAHPRLSGMVMGTNDLAKELGSRYRPDRLAMQAGLGLCLLAARAHGLTIVDGVYNAFKDEEGLRAECEQGRDMGFDGKTLIHPAQLEIANAVFSPSPAEIELANRQIAAFEEAERHGQGVAVVDGKIVENLHIVTARQTLAKAEAIAAFRAS
What is the function of this protein?
Catalyzes the hydrolysis of (3S)-malyl-CoA to (3S)-malate and free CoA.  Inactive towards beta-methylmalyl-CoA and other CoA esters.
What are the official names of this protein?
(3S)-malyl-CoA thioesterase, (3S)-malyl-CoA thiolesterase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.
Protein: PSBF_NOSP7
Sequence: MTSGNNINQPVTYPIFTVRWLAVHTLGVPTVFFLGAIAAMQFIHR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: NCAP_IHNVR
Sequence: MTSALRETFTGLRDIKGGVLEDPETEYRPGTITLPLFFSKADFDLEMIKRAVSHVGGEGTRRALGLLCAFVIAETVPSGRGTVAELLEALGFLLESLETGAPLEVTFADPNNKLAETIVKENVLEVVTGLLFTCALLTKYDVDKMATYCQNKLERLATSQGIGELVNFNANRGVLARIGAVLRPGQKLTKAIYGIILINLSDPATAARAKALCAMRLSGTGMTMVGLFNQAAKNLGALPADLLEDLCMKSVVESARRIVRLMRIVAEAPGVAAKYGVMMSRMLGVGYFKAYGINENARITCILMNINDRYDDGTSGGLTGLKVSDPFRKLAREIARLLVLKYDGDGSTGEGASDLIRRAEMASRGPDMGEEEEEDEEDDDSSEPGDSDSFL
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA.  Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation.  The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace.  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.  Protein N binds protein P in the NC through a different interaction, and can be phosphorylated.  Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N.  During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
What are the official names of this protein?
Nucleoprotein, NP, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the novirhabdovirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: XB33_ORYSJ
Sequence: MGNSLGCSASGERLVSAARDGDAVEARMLLELSPALARYSTFGGLNSPLHFAAAKGHLDIVTLLLEKGADVNVRNYCGQTALMHACRHGHWEVVQMLLLFRCNVTRADYLSGRTALHFAAHDGLVRCVRLLLADFVPSAPLEDGASSTVDGGECQTNSGSSPCSSLGLKFNESARLRYINKPADGGVTALHMAALNGHFDCMQLLIDLGANVSAVTFPYGTTANLIGAGSTPLHYAAGGGNAECCQLLLSKGASKLTLNCNGWLPIDVARMFGRRFLEPLLSPNSNSSIPAYQPSNYLALPFMSILNIAREFGLLHTVASVDDSDLCAVCLERSCSVAAEGCCHEFCIKCALYLCSTSNTRVEFTGPPGSIPCPLCRNGIMSFTKLPSTPTEGLKSSSALTFCNPCMLNTRSVDSPATISKAEIRRNRVAAVSSELVCPLTCSPFPSSALPTCRCSDDDPCDAIETQDGSEVQSPQPSHCASMEMDKREQQDLDRTSCSGMFWSRRSCHREEQCNAEINA
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase XBOS33, Ankyrin repeat domain and RING finger-containing protein XBOS33, RING-type E3 ubiquitin transferase XBOS33, XB3 protein homolog 3.
Protein: DHDH_BOVIN
Sequence: MALRWGIVSAGLISSDFTTMLRMLPRSEHQVVAVAARDLSRAKEFAKKHDIPKAYGSYEELAKDPDVEVAYIGTQHPQHKAAVLLCLTAGKAVLCEKPMGVNAAEVREMVAEARSRGLFFMEAIWTRFFPAVEALRSVLAQGTLGDLRVVRAEFGKNLTHVHRATDWAQAGGGLLDLGIYCLQFISMVFGGQKPEKISAVGRRHETGVDDTVTVILQYPGGVHGSFTCSISAQLSNTVSVSGTKGMAQLLDPCWSPTELVVKGEHKEFPLPPAPGKEFNFTNGMGMSYEAKHVRECLQKGLKESPVIPLVESELLADILEEVRKAIGITFPQDKH
What are the official names of this protein?
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, D-xylose 1-dehydrogenase, D-xylose-NADP dehydrogenase, Dimeric dihydrodiol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: RS21_NEIMB
Sequence: MPAIRVKENEPFEVAMRRFKRAVEKTGLLTELRAREAYEKPTTERKRKKAAAVKRLQKRLRSQQLPPKMY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: ALL16_CARMA
Sequence: GGPYSYGL
What is the function of this protein?
May act as a neurotransmitter or neuromodulator.
What are the official names of this protein?
Carcinustatin-16.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TVOK_THEVO
Sequence: MRPFRTLVKVLQKIESSPLTKVFMAFIIVVLIGSYLEFLTQRNVKYSEIKNYFTAIWFTMETVTTVGYGDVVPVSNLGRVVAMLIMVSGIGLLGTLTATISAYLFQIRIERRGKLEKRLKNHTIICNWNAYTRNIIEGNRDEEAAPIVILSENTDNSEKYQNVFFVKGDCTSEDDLKNAAIEDAARVVIMSDIENNAIPEDLLDAKTLLSIFTVRKLNNAVEIIAEVRDEKNKKHAVSAGATEVLSVGELSSRLISRSISNPGLTDFILKSLSETEDFKIFSIEACGILPGMTVKDAASNLAEVCVIISVISKGKIEYPPDRSYKIGAGDYVVFLAKNKKEVEEAIKG
What is the function of this protein?
Calcium-gated potassium channel.  Can also be activated by Mg(2+), Mn(2+) and Ni(2+).
What are the official names of this protein?
Calcium-gated potassium channel TvoK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NPD_PYRAB
Sequence: MIVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVVHEVRRLLQ
What is the function of this protein?
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins.  Modulates the activities of several proteins which are inactive in their acylated form.  Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_GEOSM
Sequence: MARYTGPSCRLCRREGSELFLKGERCYTDKCAIKRRSYPPGQHGQGRIKVSDYGVQLREKQKVRRIYGILENQFRGYFETADRMKGVTGENLLFILERRLDNVAYRLGFATSRDEARQLVRHGHFTLNGRKVNIPSLQVKAGDVLQLREKSRKVAAISESLEGVVRRGIPQWLELEKDAFKGTVKAMPVREDITMPIQEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.