PharMolix/UniProtQA huggingface dataset:
Protein: ST2A2_RAT
Sequence: MPDYTWFEGIPFPAFGIPKETLQNVCNKFVVKEEDLILLTYPKSGTNWLIEIVCLIQTKGDPKWIQSVTIWDRSPWIETDLGYDMLIKKKGPRLITSHLPMHLFSKSLFSSKAKVIYLIRNPRDVLVSGYYFWGKTTLAKKPDSLGTYVEWFLKGYVPYGSWFEHIRAWLSMRELDNFLLLYYEDMKKDTMGTIKKICDFLGKKLEPDELDLVLKYSSFQVMKENNMSNYNLMEKELILPGFTFMRNGTTGDWKNHFTVAQAEAFDKVFQEKMAGFPPGMFPWD
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics.
What are the official names of this protein?
Alcohol sulfotransferase A, Androsterone-sulfating sulfotransferase, AD-ST, Hydroxysteroid sulfotransferase A, STA, ST-40, Senescence marker protein 2A, Sulfotransferase 2A2, ST2A2.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBB_SHESR
Sequence: MTAFTRFAHSRASWLILTGSAIALEAAALYFQYVMKLDPCVMCIYQRLAVFGILAAGLIGMTAPKYRIVRILGALGWAVSATWGLKLALALVDMQNNPSPFSTCSFLPEFPAWMPLHEWFPSVMLPTGMCTDVPWQFMGVTMAEWMVVAFSGYLVALLLFIVPILSGSNKPSLYK
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CARAC_PSERE
Sequence: MNQIWLKVCAASDMQPGTIRRVNRVGAAPLAVYRVGDQFYATEDTCTHGIASLSEGTLDGDVIECPFHGGAFNVCTGMPASSPCTVPLGVFEVEVKEGEVYVAGEKK
What is the function of this protein?
Part of the multicomponent carbazole 1,9a-dioxygenase (CARDO), that converts carbazole (CAR) into 2-aminobiphenyl-2,3-diol.  Acts as a mediator in the electron transfer from CarAd to CarAa.
What are the official names of this protein?
Ferredoxin CarAc, Carbazole 1,9a-dioxygenase, ferredoxin component, CARDO.
Protein: PIMT_RHOPA
Sequence: MVERQIAARGVHDPRVLAAMRKVPREAFLPEPMRDLAYEDAPVPIAAEQTMSQPYIVALMVEALLLQGSDNVLEIGAGSGYAAAVLGEIAGHVTTVERIATLADAAAAKLAELGYGDVDVHRSDGTRGWPAAAPYDAIVVAAGGPQVPESLKAQLKIGGRLVMPVGADQQAQELVRLTRLGEADFKREHLGDVRFVPLLGAEGWQQPEPAGRTAREKG
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NH2L1_RAT
Sequence: MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQQSIERLLV
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Involved in pre-mRNA splicing as component of the spliceosome.  Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly.  The protein undergoes a conformational change upon RNA-binding.
What are the official names of this protein?
NHP2-like protein 1, High mobility group-like nuclear protein 2 homolog 1, OTK27, U4/U6.U5 small nuclear ribonucleoprotein SNU13, U4/U6.U5 tri-snRNP 15.5 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=Concentrated in the dense fibrillar component of the nucleolus.
Protein: LONM_ASHGO
Sequence: MLTRIRNAGVGGNAARRVRLLAGYTGARMAHAAALNSTTGAGGAARAAGAGRRAHSDVHVWALRQQSGIHRGGQCILKQDREPDQSDDKKVPPRAEEGRDEEAVRDEEAERQPREEQANRSSEASSSRGSGGSASSAGGGGRSNPPSEGEVPRKYEELMVLPMSNRPLFPGYYKSVTVYDPAVIEAICGLLRRNIPYLGAFLLKDRSMDKDSIDSIEEVHRVGVFAQITSVHHGVDVDGRKAMSMVLYPHRRVQLDELVSTPKLVAEAKEKATDDGLVQAKKEKFRDMSEGGEEEENPTEFLLETGVTVGNFSDHLDLPVDHSSVMLNALTSETLNTFKHLSSINATVKQQLIALSSITTSLKPNIFESPSLLADFAAAISVGDPNELQDVLETRDVEQRLEKALVFIKKEVYVAELQQKIEKETDAKVQKRYKDQVLTEQMRGIKKEMGVEDAKDKAIATFRERAEKLKFPEHVKKIFDEELARLSGLESAMSEYSVTKNYLDWITSLPWGIASTDQYSILSARKVLDNDHYGMQDVKDRILEFIAVGKLKGQIDGKIICLVGPPGVGKTSIGQSISRALNRTFFRFSVGGMSDVSEIKGHRRTYIGALPGRLIHALKRCQTENPLILIDEIDKLGRTGHQGDPASALLELLDPEQNKTFLDTYLDFPVDMSKVLFVCTANTLDTIPRPLLDRMEVIELSGYVADEKVKIAERHLIPAAKKSTGLGSANINLTSDSIVALLKNYCRESGVRSLKKHIEKIYRKAALKIVQQLSIDDTPKSAPAETNIEPENGKPDASAKPLTNNLPAPEPLNIPDSVKIDITPETLVEYLGPPVFTADRIYEKTPAGVVMGLAYTYLGGCTMYVESVLGQPLSKDSNPSLEHTGQLGDVMKESSRLAYSFSKMFMSRRFPNNRFFEKAAIHLHCPEGATPKDGPSAGITMASSLLSLAMNKPLDPTIAMTGELTLTGKVLRIGGIKEKTVAAKRSGAKTIIFPKDNMADWEDLPAHVKEGLIPVAAEWYDDVFNVLFGSVTEEEGNNVWKDQFDLIERSKATASSSN
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix.  May also have a chaperone function in the assembly of inner membrane protein complexes.  Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome.  Binds to mitochondrial DNA in a site-specific manner.
What are the official names of this protein?
Lon protease homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RPOB_LEPBJ
Sequence: MYGQVERKRVNFGKITNLDYLPNLIQIQKRSFDWFLQADVKDETKRKHQGLEAVFRETFPIESPNNDMIMEYSHYILGEPKRSPQECKDTDATFAMPLKAVIRLIIKETGEIREQTVYMGDLPVMTEQGTFIINGAERVVVSQLHRSPGIFFSYDMERDVFSARVIPYRGSWLEFEMDNKGILIAKIDRKKKFPATLLIKSLGHGTNEEVLRLFYSSKKEKIAGATSKDLKKILGRRTINDIINMETGEVMLEAGSKVNEDNISILKEMKVKEVELIEFPKGKDNPILINALEKDGVNDYEDAILKFHSLMRQGEPSTIENATTELTRLFFSPKTFDLGEVGRYKINSKFEFNNPKEFSGEKARVLRPADIIETVRYILNLFSETENYYPDDIDHLGNRRIRSVGELISNQLKTGFSRVERVIKERMTVQEIETQTPQLLISIKPITAVINEFFGSSQLSQFMDQTNPLAELTHKRRLNALGPGGLSRDRAGMEVRDVHYSHYGRMCPIETPEGPNIGLILSMSSYARVNDYGFLETPYRTVKNGKVTGQIEHLTADKEEYHYIAQASGVIDEKGELKNKLISTRHRGDFPFRNPSEIQYMDLAPLQVVSVSTALIPFLEHDDANRALMGSNMQRQAVPLLREEAPFVGTGMETRAAYDSRICIVNKHDGVVTSVDAETIVVERKGGKESDTYSLTKFKKTNQGTCFNQKPIVGVVHSEINGKVSKVSKEKIEVTGENGELKEYVLQIGSKQYAPIVSSGEEVKRGTTLAGQVVVGEKLDEMGNILVKGTVLADGPAVDNGVLALGRNVLAAFMPWEGYNFEDAILISERIVRDDVFSSIHIEEFEIQARETKLGPEQITRDIPNLSDKAFRDLDETGVIRIGAEVKPGDILVGMVTPKGETDLTPEYKLLHSIFGEKAKDVRDSSLRMPNGFEGTVIDIKRFSRENQDELPAGVEEMVKVFVARKRKLLVGDKMAGRHGNKGVVARVMAEEDMPYMEDGTPLDIVLNPLGVPSRMNLGQIFETQLGFAASKLGISFETPVFDGAEESDVDNFCKEANLPLNSKFKLYDGRTGLPFMNEVFCGYIYILKLAHLVEDKIHARSTGPYSLVTQQPLGGKAQFGGQRLGEMEVWALEAYGASHTLQELLTIKSDDMLGRARIYEAIVKGIHSIKPGIPESFNVLVQELRGLALDIIITDSEGNTVDISDYEDEYSKSKKKIKFETIENA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: METK_MYCGI
Sequence: MSEARLFTSESVTEGHPDKICDAISDSVLDALLAGDPKSRVAVETLVTTGQVHVVGEVTTNAKEAFADITNTVRERILEIGYDHSDKGFDGETCGVNIGIGRQSPDIAQGVDTAHETRVGGAADPLDSQGAGDQGLMFGYAIADTPELMPLPIALAHRLSRKLTEVRKNGTLDYLRPDGKTQVTVQYDGTTPVRLDTVVLSTQHADGIELDSQLEPEIKQHVIDAVLTELGHQTLDTSNPRILVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGSETVDPVKIEKAIGEVFDLRPGAIVRDLDLLRPIYAPTAAYGHFGRTDIELPWEQLNKVDDLKSAV
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLSA_ALISL
Sequence: MKPTKQILEDILNEVRPLIGQGEVADYIPALACVPSNKLGIAVYTNDGEMITAGDANERFSIQSISKALSLTLAMELYQPEELWHRVGKEPSGQAFNSLIQLEMEQGVPRNPFINAGAIVVADMLFSRFSAPKHRLLEFVRKLSGNEHIIYDRVVANSEMDHSDRNASIAYLMRSFGNFENEVMPVLKNYFHACSLNMSCVDLAKTFGYLANKGIQPETNEFIITPMQSKQINALMATCGLYDGAGEFAYRVGMPGKSGVGGGIIAIVPGEMTIAVWSPELDPSGNSLAGTQALELLSERIGRSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: PYRG_POLNA
Sequence: MTKFVFVTGGVVSSLGKGIASGALAAILESRGLKVTLIKLDPYINVDPGTMSPLQHGEVFVTDDGAETDLDLGHYERFIETRMRKANNFTTGQIYQSVLDKERRGDYLGKTVQVIPHITNEIQDFIKRGARYDTPDAVDVAIVEIGGTVGDIESLPFLEAVRQMSLRMGPNNSAFVHLSYVPWIAAAGELKTKPTQHTAKQLREIGIQADVLLCRADRPIPTEERDKISLFSNVPAWGVISMWDVDTIYKVPRMLHEQGLDGLICDKLRLHTPPANLKRWDDLVYATEHPQTEVSIAMVGKYVDLSDSYKSLNEALRHAGMKNHAKVVITYVDSETLTPDTVSSLAQFDGILVPGGFGVRGVEGKICAARFARENKIPYLGICLGMQVATIEFARHVAGLKDANSTEFDPLTPHPVIALITEWKDADGTIKTRHAKSDLGGTMRLGAQSSDVSPNSLAHSIYGDVVTERHRHRYEANVNYLDTLRKSGLVISALTQREHLTEIVELPQDVHPWFVGVQFHPEFKSTPWDGHPLFNAYIAATLEQRSALSQAKKAETAKPLKVVAST
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: HEM2_RUMJO
Sequence: MIKRPRRLRTNEVLRKAVRETRLSTDSLIWPLFIVEGKNIKKEISSLPGQYHFSPDMVGKAIEAALKADVKSVLLFGLPKHKDEKGSEAYNENGVLQQGIREIKQRYPQMQVITDICMCEYTSHGHCGILEGERVDNDRTLPYLEKIALSHVMAGADMIAPSDMMDGRIYALRSTLDKNGFTDIPIMSYAVKYASSFYGPFREAA
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: TPM_PANST
Sequence: MKLEKDNAMDRADTLEQQNKEANIRAEKAEEEVHNLQKRMQQLENDLDQVQESLLKANTQLEEKDKALSNAEGEVAALNRRIQLLEEDLERSEERLNTATTKLAEASQAADESERMRKVLENRSLSDEERMDALENQLKEARFLAEEADRKYDEVARKLAMVEADLERAEERAETGESKFVELEEELRVVGNNLKSLEVSEEKANQREEAYKEQIKTLTNKLKAAEARAEFAERSVQKLQKEVDRLEDELVNEKEKYKSITDELDQTFSELSGY
What is the function of this protein?
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
What are the official names of this protein?
Tropomyosin, Allergen Pan s I.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
Protein: SYE_SHISS
Sequence: MKIKTRFAPSPTGYLHVGGARTALYSWLFARNHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLSLEWDEGPYYQTKRFDRYNAVIDQMLEEGTAYKCYCSKERLEALREEQMAKGEKPRYDGRCRHSHEHHADDEPCVVRFANPQEGSVVFDDQIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVVDDWDMEITHVIRGEDHINNTPRQINILKALKAPVPVYAHVSMINGDDGKKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEIFTREEMIKYFTLNAVSKSASAFNTDKLLWLNHHYINALPPEYVATHLQWHIEQENIDTRNGPQLADLVKLLGERCKTLKEMAQSCRYFYEDFAEFDADAAKKHLRPVARQPLEVVRDKLAAITDWTAENVHHAIQATADELEVGMGKVGMPLRVAVTGAGRSPALDVTVHAIGKTRSIERINKALDFIAERENQQ
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2883_BRASB
Sequence: MTVSAAVQQQAGEAGLLPSHQARLDYRTGKGWSTAGVANGFVQGNLAIIPEQYAGAFHRFCQLNPKPCPIIGMSDPGNPFIPALGADLDIRTDVPRYRVWRDGEMVEEPTDLLAHWLDDLVTFVLGCSFSFEEALMADGLPIRHIEQGCRVPMYRTNIACTPSGPFAGPMVVSMRPFKPAQAIRAVQITTRFPAVHGAPVHLGHPDQIGIVDINKPDYGDPVPVAADEIPVFWACGVTPQAVISAAKLPFAITHAPGLMLITDLKNKDLAVL
What are the official names of this protein?
Putative hydro-lyase BBta_2883.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: LUXS_STRPD
Sequence: MTKEVIVESFELDHTIVKAPYVRLISEEFGPKGDRITNFDVRLVQPNQNSIETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIMWGKHSSTDIAKVIKSSLEEIATGITWEDVPGTTIESCGNYKDHSLFAAKEWAQLIIDQGISDDPFSRHVI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: RL18_SHIFL
Sequence: MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RL15B_YEAST
Sequence: MGAYKYLEELERKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTRPDKARRLGYKAKQGFVIYRVRVRRGNRKRPVPKGATYGKPTNQGVNELKYQRSLRATAEERVGRRAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWICNPVHKHREARGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWRYRK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L15-B, L13, Large ribosomal subunit protein eL15-B, RP15R, YL10, YP18.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECJ_HAEIN
Sequence: MKKLIKRREIPIGNSVSNHPLLDRLYRARHIQNTKELDRTLKSMLNPNQLYGIEQAVNLLVEAYQPQQKIVIVGDFDADGATSTALSVLALRQLGFSDVDYLVPNRFEQGYGLSIPVAEMAIEKGVQLLMTVDNGVSSFDGVAFLKEKGIRVLVTDHHLPPETLPPADAIVNPNLSQCGFPSKSLAGVGVAFYLMLAVRAKFRELGIFTAETQPNFTDLLDLVALGTIADVVPLDQNNRILAYQGLMRIRARHCRLGIIALAEVANRNVEQFTSSDLGFCIGPRLNAAGRLDNMSIGVELLLANEMSKARELALDLDQLNQTRKEIEAGMKLEAIKICQNLTALFKELPYGITLYQPDWHQGVLGIVSSRIKDQYHRPVIAFAQDSEGILKGSARSIEGLHMRDVLERIHSQHPNMILKFGGHAMAAGLSIREEHFADFQHIFNQTVADWLDEEHLQGVIWTDGELNSNEFNLETAELIKSVGTWGQGFPEPCFDGEFKILDQRAIGQNKNHLKMLLEPKQGGVLLDAIAFNINTRLYPDLSIKQARLAYKLEINEFRGNRSLQLLVDYIEPIDE
What is the function of this protein?
Single-stranded-DNA-specific exonuclease.  Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available (By similarity).
What are the official names of this protein?
Single-stranded-DNA-specific exonuclease RecJ.
What is the protein family that this protein belongs to?
Belongs to the RecJ family.
Protein: END4_THET2
Sequence: MPRYGFHLSIAGKKGVAGAVEEATALGLTAFQIFAKSPRSWRPRALSPAEVEAFRALREASGGLPAVIHASYLVNLGAEGELWEKSVASLADDLEKAALLGVEYVVVHPGSGRPERVKEGALKALRLAGVRSRPVLLVENTAGGGEKVGARFEELAWLVADTPLQVCLDTCHAYAAGYDVAEDPLGVLDALDRAVGLERVPVVHLNDSVGGLGSRVDHHAHLLQGKIGEGLKRVFLDPRLKDRVFILETPRGPEEDAWNLRVLRAWLEEA
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate (PubMed:16782061, PubMed:20410075).  In addition, possesses a 3'-5' exonuclease activity (PubMed:16782061).
What are the official names of this protein?
Endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV, TthNfo.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: EL2A_HORSE
Sequence: IVGGRAAEPHSRPYMVSLQIRGNPGSHFCGGTLIMGWGRLGTREPLPXVLQELNVTVVTAGICFGDSGGPLICNGVAQGVFSFVR
What is the function of this protein?
May be involved in the degradation of connective tissue in chronic lung disease.
What are the official names of this protein?
Neutrophil elastase 2A, Proteinase 2A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Elastase subfamily.
Protein: ANF_FELCA
Sequence: MGSFSTITASFLLFLACQLLWQTGANPVYGSVSNADLMDFKNLLDHLEDKMPLEDEVVPPQVLSEQNEEAGAALSPLPEVPPWAGEVNPAQRDGGALGRGSWDSSDRSALLKSKLRALLAAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRYRR
What is the function of this protein?
May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation.  In vivo promotes natriuresis.  In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
What are the official names of this protein?
Natriuretic peptides A, Atrial natriuretic factor prohormone, preproANF, proANF, Atrial natriuretic peptide prohormone, preproANP, proANP, Atriopeptigen, Cardiodilatin, CDD, preproCDD-ANF.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
[Long-acting natriuretic peptide]: Secreted. Note=Detected in blood. SUBCELLULAR LOCATION: [Vessel dilator]: Secreted. Note=Detected in blood. SUBCELLULAR LOCATION: [Kaliuretic peptide]: Secreted. Note=Detected in blood. SUBCELLULAR LOCATION: [Urodilatin]: Secreted. Note=Detected in urine. Not detected in blood. Increased electrolytes, osmolality and intracellular cAMP levels increase peptide secretion/excretion. SUBCELLULAR LOCATION: [Atrial natriuretic peptide]: Secreted. Perikaryon. Cell projection. Note=Detected in blood. Detected in urine in one study. However, in another study, was not detected in urine. Detected in cytoplasmic bodies and neuronal processes of pyramidal neurons (layers II-VI) (By similarity). Increased secretion in response to the vasopressin AVP (By similarity). Likely to be secreted in response to an increase in atrial pressure or atrial stretch. In kidney cells, secretion increases in response to activated guanylyl cyclases and increased intracellular cAMP levels. Plasma levels increase 15 minutes after a high-salt meal, and decrease back to normal plasma levels 1 hr later (By similarity). SUBCELLULAR LOCATION: [Atriopeptin-3]: Secreted. Note=Detected in blood. Slight increase in secretion in response to the vasopressin AVP.
Protein: RSME2_BORBU
Sequence: MKQIVLDENCLAGNFIIVKDAKIYHHLVNVRRLKKGDKLNILLKDKELRASEIVKIGSNFIKFTTNKIDKIEKNNFEISIFISSLKGRKIDLVLRQVVEIGVSEINIINADRSVSKIDINNASAKILRFSKIIDEALKQSGNKIVPKINFYNNFFYLPYSFCTTRYYVAHPSGMILSKNESFDNFGKIGIIIGPEGCFSESEIVFFKEKGFNFVRFNTPILRADTAIIYSLAYFKALLEDYNG
What is the function of this protein?
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA.  Acts on the fully assembled 30S ribosomal subunit (By similarity).
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase E 2, 16S rRNA m3U1498 methyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RsmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3393_SYNFM
Sequence: MTGMESPRDIRARIARSQWTKPTTGLAPAYAQANVVILDRRYAFDFLLFCVRNSKPCPILEVLEPGVTEPHATAPGADIRTDVPLYRVWRKGRLEQEATDITGCFDAGMVSFLLGCSFTFEASLTGAGVPVRNIEEGKNVSMYVTNRKCASAGPFSAPLVVTMRPIPNDLVMRAVRITSRYSLAHGAPIQVGDPGALGIRDLDRPDFGDPVTVKDGETPVFWACGVTSSLAVLSAEPELCITHAPGHMFITDVLNETLAAL
What are the official names of this protein?
Putative hydro-lyase Sfum_3393.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: ACH1_CAEEL
Sequence: MSVCTLLISCAILAAPTLGSLQERRLYEDLMRNYNNLERPVANHSEPVTVHLKVALQQIIDVDEKNQVVYVNAWLDYTWNDYNLVWDKAEYGNITDVRFPAGKIWKPDVLLYNSVDTNFDSTYQTNMIVYSTGLVHWVPPGIFKISCKIDIQWFPFDEQKCFFKFGSWTYDGYKLDLQPATGGFDISEYISNGEWALPLTTVERNEKFYDCCPEPYPDVHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAGEKITLQITVLLSICFFLSIVSEMSPPTSEAVPLLGIFFTCCMIVVTASTVFTVYVLNLHYRTPETHDMGPWTRNLLLYWIPWILRMKRPGHNLTYASLPSLFSTKPNRHSESLIRNIKDNEHSLSRANSFDADCRLNQYIMTQSVSNGLTSLGSIPSTMISSNGTTTDVSQQATLLILHRIYHELKIVTKRMIEGDKEEQACNNWKFAAMVVDRLCLYVFTIFIIVSTIGIFWSAPYLVA
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity).  A subunit of the levamisole-insensitive nicotinic receptor.
What are the official names of this protein?
Acetylcholine receptor subunit alpha-type acr-16.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=The cam-1 protein is required for correct localization.
Protein: CTAA_BACC0
Sequence: MQRFIKWLAVITSLDLLIVLLGGALVTKTGSGQGCGKSWPLCNGEFVPSNLSMETIIELSHRLTSGSAGILVTLLCILSWKYYKHVRETKTLAILSFVFLVAQALMGAAAVVWGQMPAVLAIHFGISLISFASVILLTCLIFEIDQKFDARSLIMDKKMKFHIYGVTIYCYLVVYTGALVRHERASLACPDFPLCSKNRPMPTQLHEWVQMGHRVAAMLIFAWILYAMILAIRHYKQQPVVYWGWIISFILVTLQAIVGILVVFTNASLAMALLHSLFISCLFAVLCYLVMLGTRSKVNAKEAASTSKQTK
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.