PharMolix/UniProtQA huggingface dataset:
Protein: MACB_PHOLL
Sequence: MNALLELKGIERSYPAGEQQIKVLDDVTLSIYAGEMVAIIGASGSGKSTLMNILGCLDQPSNGEYRVAGQNVAELNNDELAALRREHFGFIFQRYHLLTHLTAEQNVEIPAIYAGAAKAARRQRAIELLGRLGLEDRIYYQPGQLSGGQQQRVSIARALMNGGQVILADEPTGALDSHSGEEVMAILKQLCEQGHTVIIVTHDPKIAAQAQRIIEIKDGHIMSDSGTQVSRKITQTPSLTSKISSIRQIFGRFNEALFMAWRAMVVNKMRTLLTMLGIIIGIASVVTILVIGDAARASVLSDIKEIATNTIDIYPGEDFGIDDPVSKQALKIADADAIKVQPYILAVSPEIEGQMRLRKGNIDVSSKVTGVGDEYFQVYALRFAQGIGFSLDMIRRQGQVVVIDKNTQRKLFPHQKNVIGEVILVGNMPATIVGVIANRESAFGNSKLLHIWLPYSTMTSRLMNRSYLDSITVRVKDDYNSKDAEKMIVQLLTLRHGKKDIFTDNVDMLVKAAEKTAHTLQLFLTMVAVISLIVGGIGVMNIMLVSVTERTREIGIRMAVGARTSDVRQQFLIEAILVCLVGGVLGIGLSYTIAFIAQLALPGWHFVFQPIALLSAFACSTAIGVIFGFLPARNAARLDPIEALARE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BIOB_STUS1
Sequence: MSATSASVTRHDWSLAEVKALFEQPFNDLLFQAQTVHRQHFDPNRVQVSTLLSIKTGACPEDCKYCPQSGHYNTGLDKEKLMEVQKVLEAAAEAKAIGSTRFCMGAAWKHPSAKDMPYVLKMVEGVKAMGLETCMTLGKLDQEQTRALAAAGLDYYNHNLDTSPEFYGNIITTRTYAERLETLSYVREAGMKICSGGILGMGESLDDRAGLLIQLANLPEHPESVPINMLVKVKGTPLAEEQDVDPFDFIRMLAVARIMMPKSHVRLSAGREQMNEQMQALAFFAGANSIFYGEKLLTTANPQADKDMQLFARLGIKPEERQEHADEVHQAAIEQALIEQRDSKLFYNAAV
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: PSBF_BUTUM
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: POXIN_CWPXB
Sequence: MAMFYAHAFGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSYVNKRYIGALLPMFECNEYLQIGDPIHDLEGNQISIVTYRHKNYYALSGIGYESLDLCLEGVGIHHHTLEAGNAVYGKVQHDYSTIKEKAKEMNSLSPGPIIDYHVWIGDCVCQVTAVDVHGKEIMRMRFKKGAVLPIPNLVKVKLGEENDTVNLSTSISALLNSGGGTIEVTSKEERVDYVLMKRLESIRHLWSVVYDHFDVVNGKERCYVHMHSSNQSPMLSTVKTNLYMKTMGACLQMDYMEALEYLSELKESGGRSPRPELPEFEYPDGVEDAGSIERLAEEFFSRSELQADEPVNFCNSINVKHTSVSAKQLRTRIRQQLPSILSSFANTDGGYLFIGVDNNTHKVVGFTVGQDYLKLVESDIEKYIKRLRVVHFCEKKEDIKYACRFIKVYKPGEETTSTYVCAIKVERCCCAVFADWPESWYMDTSGSMKKYSPDEWVSHIKF
What is the function of this protein?
Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity.  Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses.
What are the official names of this protein?
Poxin-Schlafen.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the Schlafen protein family. Subgroup poxviridae B3 subfamily.
Protein: DNLJ_MACCJ
Sequence: MNIEQRVTELHQLLHQYNYEYHVQDNPSVPDSEYDKLLHELIDIEREHPELKTDDSPTVRVGGTPVSAFEKVDHDTPMLSLGNAFSEEDLLAFDKRVKDEVGEVEYMVELKIDGLAVSLKYVDGVFVQGLTRGDGTTGENITQNLKTIHAIPLTLSVPLTFEVRGEAYMPRKSFLALNAYREKVGEPLAANPRNAAAGSLRQLDSKLTAKRKLDIFLYSVNDLRELNAQSQSEALDKLDEIGFKTNHERKLCRNMEEVFEYIKYWTEKRNDLAYDIDGIVIKVNDLSKQDELGFTAKSPKWAIAYKFPAEEVITTLNDIELSIGRTGVVTPTAILEPVKVAGTTVGRASLHNEDLIREKDIRIGDSVVIRKAGEIIPEVVRVVLDRRPEGTKPYNMPEICPSCGHELVRIEGEVALRCINPKCDAKLVEGVIHFVSRTAMNIDGLGERIVEVLYNEDIINDVADLYTLERERLLTLERMGEKKVDKLLAAIEASKTNSLERLLFGLGIRHLGAKASMVLAREFGTMDNLKNATVETLTQIDDIGEKMAQSLVTYLQNEDIINLLEKLEQYGVNMRYTGVTKDDIELHPVFGEKTIVLTGKLTIMSRSEATKALTNLGAKVTNSVTKKTDIVIAGSDAGSKREKADSLGIPVWTEQMMVDALRN
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PRI1_DROME
Sequence: MPEQVTDQENQAPQQQTTAVHAYNPEVLQDMLPVYYRRLFPHLPFYRWLSYGSSEDAIFSNREISFTLQDDIYIRYLCFDTQAELEKEICSRNPIKIDIGPVMHSKPKNHRSIPGGLTPVQRELVFDIDMTDYDEVRTCCSGAGVCLKCWKFMVLAARVLDVALREDFGFEHIIWIFSGRRGIHCWVCDYQARHLDGRGRYAVAEYLNIITYASFAGGNSPRCSMGDRPHHSLKRALKIVEPMFEEIVLEDQNLFGTPKGVTKLLNMVHDDAARGELESYMQKNLEDGAHSRLVWESFIKYANSMRTSTTSAWSRKLKNIVAEIQLGLLYPRLDINVTRGFNHLLKAPFCIHPATGKVCVPFSVSAVAKFDPTTVPTITQLLHEINAFDDKSKSYMEAPEDKSRIKDHKKTSMFKGVVVFEEFLRKLERSQKSASLQF
What is the function of this protein?
Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:6773966, PubMed:6806812, PubMed:6812052, PubMed:6403945, PubMed:6409898).  During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (By similarity).  The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity).  These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).  In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (By similarity).  Can add both ribo- and deoxynucleotides during elongation of the primers (PubMed:6812052).  Binds single stranded DNA (By similarity).
What are the official names of this protein?
DNA primase small subunit, DNA polymerase subunit A, DNA polymerase subunit gamma, DNA primase 50 kDa subunit, dPRI50.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: GLNE_MYCBO
Sequence: MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVDLLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALGDHLVAHPQSWKLLRGKVTLPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVVAARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMGKCGARELNYVSDVDVIFVAERSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLESHIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLEHRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHTKLFYQPLLESIGPTGLEIAHGMTLEAAGRRLAALGYEGPQTALKHMSALVNQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESWYLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARALIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVTEVCRALTSVWVAVLQAALDVMIRASLPDDDRAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPATGVDDARAVKWSTSIAERVRALLGTPSVDPPLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAADVELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRNDDGGEFLDNYLRVTRRAKAVVRKVFGS
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: UFC1_ARATH
Sequence: MEGWDPNTKSTLTRIPLLTTKAGPRDGAAWTQRLKEEYKSLIAYTQMNKSNDNDWFRISASNPEGTRWTGKCWYVHNLLKYEFDLQFDIPITYPATAPELELPEIDGKTQKMYRGGKICLTVHFKPLWAKNCPRFGIAHALCLGLAPWLAAEIPILVDSGAIKHKDDAATSAES
What is the function of this protein?
E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.
What are the official names of this protein?
Ubiquitin-fold modifier-conjugating enzyme 1, Ufm1-conjugating enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
Protein: RL30_LACH4
Sequence: MTDLKITLIRSAAHSLPEQRKTVKALGLGRVNSTVVLPDNAATRGALLKIAHLISVEEINK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: PDI_ARTBC
Sequence: MPGVRSLLLALAGVSLAPAVLAADASTDSSDVHALKTDTFKDFIKEHDLVLAEFYAPWCGHCKALAPEYEKAATELKSKNIQLAKVDCTEEADLCQEYGVEGYPTLKVFRGLDSHKPYNGARKSPAITSYMIKQSLPSVSVVTAENFEEVKSLDKVVVVAFIGEDDKETNKTYTALADSMRDDVLFAGTSSAELAKKEGVSLPAVVLYKEFDDRKDVYDGKFEAEALKAFIKSSSTPLVGEVGPETYSGYMSAGIPLAYIFADTAEEREQYASDFKDLAKKLKGKINFATIDSKAFGAHAANLNLIPEKFPAFAIQDTVSNKKYPFDQEKKLTKQDITKFVEGVIAGDIAPSVKSEAVPETNDGPVTVIVAHTYEEIVMNKDKDVLVEFYAPWCGHCKALAPKYDQLGSLYKDNKDFASKVTIAKVDATANDIPDEIQGFPTIKLFPADDKDKPVEYTGSRTIEDLANFVRDNGKHKVDAYDEKKVEKDGSDVTGKPKDAEAPPKPSDAPESEEKADKEHEEL
What is the function of this protein?
Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
What are the official names of this protein?
Protein disulfide-isomerase, Allergen Alt a 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: TRUB_METBF
Sequence: MSPAGKLPSEAERILVRKSGAWTNPSYGSYPEKRPILEYIEKGVVNIDKPKGPTSHEVAAWVKAILGVSTAGHAGSLDPKVTGLLPTLLGKATKAVPALRLSGKEYVCLLKLHKEMPQKLVRKVCEEFTGPIYQMPPIKSAVKRVIRIRTIYYLEVLEIEGSFVLFRVGCEAGTYIRKLCHDIGLALGCGGHMQELRRTKAGPFTEETLVTLQDLKDAYVLWKEDGDESEIRRVIMPMETAVSHLPKIILRDSAVDAICSGAALAVPGITSLDANLKKGELIALFTLKGELVALAKAEMSTEELLKASTGLAATSVRIMMEIGTYPKGWTKKEYGVES
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
Protein: AUSG_PENBI
Sequence: MAMVTPGLWANFSHSSHELGIANGFEFLNSLLVAYRLPGLLLLFSITIILFQPLRKKSDLPLINSGKGPFSILRGYRSRKTFAAELPRLVAEGLSKASAFRIAAPDGVNIVLAPSYAHEIGEHPDLNPGPIAGDEFNCHIDGFEVFAQLGTSDVISESVRTRLTRQLTKLTPLLTSETALLLQSQWKDAPNWVEVSPHETAMFILSRLSSLVFVGDDLGRNPDWVHILTSYNNEAFAAAEELNLWPQILRPLVAHLKPSCRQLRRYIRDARALLIPVIEQRHHAQSQGDRREYNDAIEWLNETSHSLAQSYDPLLSQMLLAIGSFHTSSDLLGQVLLDLCMRQDWEVLVGELRKEIISSLQGVGWDKISLNNLKLMDSVLKESQRLKPASTVTMGRYASREIILSDGTRIPKGSTVFIANVAMRDPNIYPDPDVFIPDRFTTRREKGDSSAYLVSASPEHIGFGLGRHACPGRFFAANEVKIVLSHMLLKYDIKLPDNGAAVAPSTSGIFLETNPNARICVRRRKEEILI
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster B that mediates the biosynthesis of the fungal meroterpenoid acetoxydehydroaustin (PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (By similarity).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (By similarity).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG then modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:29076725).  The cytochrome P450 monooxygenase then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:29076725).  The hydroxylation catalyzed by ausR permits the second O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:29076725).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end product of the Penicillium brasilianum austinoid biosynthesis clusters is acetoxydehydroaustin (PubMed:29076725).
What are the official names of this protein?
Cytochrome P450 monooxygenase ausG, Austinoid biosynthesis clusters protein G.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NOGG1_DANRE
Sequence: MDFPRFLLSAYLLLLSFAQCQHYYLLRPIPSDTLPLLELKEDPDPIYDPREKDLNETELRSALGDFDSRFLSVGPPQDRYAGNEDLDEQELQLNLAGMMPKDIKNLDFDAPWGKKRKASKKLKRRLQMWLWSYSFCPVLYAWNDLGSRFWPRFVRAGSCYTKRSCSVPEGMVCKPAKSTHITLLRWRCVARRGALKCAWIPVQYPIITECKCSCAN
What is the function of this protein?
Inhibitor of bone morphogenetic proteins (BMP) signaling.  May play an important role in the dorsoventral patterning of the embryo.
What are the official names of this protein?
Noggin-1.
What is the protein family that this protein belongs to?
Belongs to the noggin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PANB_CLOB1
Sequence: MRNTVSTFQELKNKGEKITMLTAYDYSMAKLIDSSGINGILVGDSLGMVCLGYENTLSVTMEDMLHHTKAVVRGTSNALVVGDMPFMSYQTSIYDAVYNAGRFIKEAGAHAVKLEGGATVAEEIKAIVKAQIPVMGHIGLTPQSVNMFGGFKVQGKNEKVAKKLIEDAKILEEAGAFSIVLECIPEKLSKIISESISIPTIGIGAGKYCDGQILVYQDMLSMFSDFKPKFVKSFGNIGESIKDGVSQYIKEVKEVKFPEEKHAFKIDDDVINKLY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_PSEPF
Sequence: MSKQILILPGDGIGPEIMAEAVKVLELANEKYSLGFELSHDVIGGAAIDKHGVPLADETLDRARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRAQLGLFGNLRPAILYPQLADASSLKPEIAAGLDILIVRELTGGIYFGAPRGTRTLENGERQSYDTLPYSESEIRRIARVGFDMARVRGKKLCSVDKANVLASSQLWREVVEQVAKDYPDVELSHMYVDNAAMQLVRAPKQFDVIVTDNMFGDILSDEASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGKGIANPLATILSVSMMLRYSFNLHEAADAIEKAVSVVLDQGLRTGDIFSTGCTKVGTQEMGDAVVAALRNL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_XANOR
Sequence: MFSRDVRLETYDPELAKAIAAEAGRQEDHVELIASENYCSQLVMEAQGSQLTNKYAEGYPGKRYYGGCAFVDIAEQLAIDRIKQVFDADYANVQPHSGSQANQAVYLALLQPGDTILGMSLAHGGHLTHGAKANVSGKLFNAVQYGVNEQGLIDYDEVQRLATEHTPKMVVAGFSAYSQKIDWARFRAIADSVGAYLFVDMAHIAGLVAAGVYPSPMEHAHVVTSTTHKTLRGPRGGIIVAKGASEELQKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKTYQQQVVKNAQAMANTLIARGYKIVSGGTENHLMLVDMIGRDVSGKDAEAALGKAHITVNKNAVPNDPRSPFVTSGLRLGTPAITTRGYKEPDSIDLANWIADVLDAPTDEAVLAKVRDAVTAQCKRYPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNAS6_BOVIN
Sequence: MGPHLLGRSSLLLLLLGMWWSVRPLCAVPKGLTKARWFEIQHIQPRLLQCNKAMSGVNNYTQHCKPENTFLHNVFQDVTAVCDMPNIICKNGRHNCHQSPKPVNLTQCNFIAGRYPDCRYHDDAQYKFFIVACDPPQKTDPPYHLVPVHLDKVV
What is the function of this protein?
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:3926759).  Has potent antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, including P. aeruginosa, A. baumanii, M. luteus, S. aureus, E. faecalis, E. faecium, S. saprophyticus and E. coli (By similarity).  Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity).  Probably contributes to urinary tract sterility (By similarity).  Bactericidal activity is independent of RNase activity (By similarity).
What are the official names of this protein?
Ribonuclease K6, RNase K6, K6b, Ribonuclease K2, RNase K2.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Lysosome. Cytoplasmic granule.
Protein: NUOB_XANC8
Sequence: MGVIQTLDRLMTNPMPEGRVEDILRPEGENPLLEKGYVTTSVDALLNWARTGSMWPMTFGLACCAVEMMHAGAARLDLDRYGVVFRPSPRQSDVMIVAGTLVNKMAPALRKVYDQMPDPKWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALVYGILQLQKKIWRTQTIAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: KDUI_LACE2
Sequence: MEVRQGANARDVKGYDTERLRNDFLIQNLFPADDFKLVYSQIDRIIVGGCMPVNKELTLEAGSELKAAYFLERREMGIFNVGGNGSVIVDGTEYKFKYRDGLYIGMGSKEIKFKSEDSSKPAKFYFNSTPAHKTYPTVFIDPEKDIKDEFKLQLGSVEGCNKRLNRKYILPGQVETCQLEMGITTLEPGSVWNTMPCHTHDRRMEVYFYFEIPEEDIVVHYMGEPTETRHIIMRSEEAVISPSWSIHSASATHAYAFIWGMAGENQDFDDMDWVDMKDLK
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: GBG7_HUMAN
Sequence: MSATNNIAQARKLVEQLRIEAGIERIKVSKAASDLMSYCEQHARNDPLLVGVPASENPFKDKKPCIIL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.  Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain.  Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7.
What is the protein family that this protein belongs to?
Belongs to the G protein gamma family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: GRXS9_ARATH
Sequence: MDKVVRMSSEKGVVIFSKSSCCMSYAVQVLFQDLGVHPTVHEIDKDPECREIEKALMRLGCSTPVPAIFVGGKLIGSTNEVMSLHLSGSLVPLVKPFQANLC
What is the function of this protein?
May only reduce GSH-thiol disulfides, but not protein disulfides.
What are the official names of this protein?
Monothiol glutaredoxin-S9, AtGrxS9, Protein ROXY 7.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. CC-type subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_SALHS
Sequence: MSEFVTVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENNRLNALPDVLEQFIHLRAASEATSEVEVTSATALSEEQLSKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DCNL1_CHICK
Sequence: MNKLKSSQKDKVRQFMVFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASITVLIIAWKFRAATQCEFSKLEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV
What is the function of this protein?
Part of an E3 ubiquitin ligase complex for neddylation.  Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes.  Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates.
What are the official names of this protein?
DCN1-like protein 1, DCUN1 domain-containing protein 1, Defective in cullin neddylation protein 1-like protein 1.
What are the subcellular locations of this protein?
Nucleus.