PharMolix/UniProtQA huggingface dataset:
Protein: LEU1_PSEFS
Sequence: MSMLKDPSSKYRAFPTIDIPDRTWPSKTITEAPIWCSSDLRDGNQSLIEPMDAVKKLRFWKTLVAVGVKEIEASFPAASQTDFDFVRTLIEDNHIPEDTTIQVLTQGREDLIARTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKEGIKAIAVNAAKLFVKYAAQQPETQWTFEYSPETFSATELEFAKEVCDAVIEVWNPTPEHKMILNLPATVECATPNIYADQIEWFGRHINRRDSVIISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNMYTQGLDPQLDFSDIDGVRKVVEECNQIQVHPRHPYVGDLVHTAFSGSHQDAIRKGFTQQKDDALWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYDISLPRRMQIEFSQVVQAETDRVGLEMTAPQIYALLQREYLQANTPYALVSHRLQEENGNSFVEVEVSGKGQGETNLHWKGKGNGALEALVAGLPIGVEIMDYNEHAIGAGTNAKAAAYIELRVNGERPVHGVGIDENITTASFKALFSALNRSLSQQEAKAA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: CYB_MUSAV
Sequence: MTNFRKSHPLMKIINDSFIDLPTPSNISAWWNFGSLLGACLGIQILTGLFLAMHYTSDTLTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHIGRGMYYGSYMFMETWNIGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIVAALVMVHLLFLHETGSNNPSGLNSDTDKIPFHPYFTIKDILGLLLLISILMSLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILAIFPMIQISKQRSMMFRPLSQLLFWILTADLFTLTWIGGQPVEHPFIIIGQLASVLYFSIILVFLPTTSLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HEM3_OLEA2
Sequence: MKKIVIATRGSKLALWQAEHIKERIMQQYPDSFEVELLVLKTKGDIILDVPLAKVGGKGLFVKEIEEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQGAVVGTSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAPFHSELGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGCQVPIAGYAVMTGDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADAILQRVYENGHASPQA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CBID_GEOKA
Sequence: METKKTLREGYTTGSCAAAATKAALTALITGQVQTDATIRLPIGRVVTFSLASCSFEGETATAAVVKDGGDDPDATHGALIVSTVSWASSPGVHIDGGEGVGRVTKPGLPVPVGEAAINPVPRQMIREAVNEVLAQYGLHRGVKVVISVPGGEEIAKKTLNPRLGIMGGISILGTRGIVVPFSTAAYRASIVQALQVAKANGCRHVVITTGGRSEKYAMQEYPHLPEEAFIEMGDFVGFTLKQCKRLGIKMVSMVGMMGKFSKVAQGVMMVHSKSAPVDFGFLAALAEQAGASSALVAAVRGANTAAQVGDMMQEAGCTKFFELLCEACCRAALNEVGGGLTVATSIYTMNGQRLGKAVQIDGDDETDRRGS
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: NEMA1_LINLO
Sequence: YRIASSSIAKMKTAVFLVGLLFLGLVFADEAAIDSEFDQSIDKRGCIATGSFCTLSKGCCTKNCGWNFKCNPPNQK
What is the function of this protein?
Highly potent toxin against insect sodium channel (Nav) and with less potent activity against mammalian sodium channels (PubMed:29567943).  Potently inhibits inactivation of insect sodium channels of B. germanica (BgNav1) (EC(50)=8. 6 nM), D. melanogaster (DmNav1), and arachnid sodium channel V. destructor (VdNav1) (PubMed:29567943, PubMed:34445875).  Also delays the inactivation of most mammalian Nav channels tested (hNav1. 1/SCN1A; EC(50)=124. 1 nM, rNav1. 2/SCN2A; EC(50)=359. 6 nM, rNav1. 3/SCN3A; EC(50)=135. 4 nM, rNav1. 4/SCN4A; EC(50)=145. 5 nM, hNav1. 5/SCN5A; EC(50)=138. 3 nM, mNav1. 6/SCN8A; EC(50)=240. 4 nM, hNav1. 9/SCN9A; EC(50)=76. 5 nM) (PubMed:29567943, PubMed:34445875).  1 uM is enough to completely inhibits the inactivation, resulting in sustained non-inactivating currents (PubMed:29567943).  In addition, the toxin significantly enhances the recovery from inactivation, and the open state is not required for the toxin to interact with the channel (PubMed:29567943).  In vivo, injection into green crabs (Carcinus maenas at 1 mug/kg) of small doses (1-5 ug/kg) results in slow and fast permanent paralysis, whereas injection of high doses (more than 10 ug/kg) causes death (PubMed:29567943).  Injection into juvenile Blaptica dubia cockroaches results in death or permanent paralysis at doses higher than 7. 1 ug/kg (PubMed:29567943).  Injection into brine shrimp (Artemia salina) stops movement or causes death after 24 hours (EC(50)=0. 3 uM) (PubMed:34445875).  In the rare inherited cardiac arrhythmia Brugada syndrome 1 (BRGDA1), this toxin is able to restore the loss of function by reducing channel inactivation, without affecting activation, by binding to Nav1. 5/SCN5A (PubMed:32850980).
What are the official names of this protein?
Nemertide alpha-1.
What is the protein family that this protein belongs to?
Belongs to the nemertide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPO2C_HALSA
Sequence: MSTEREAKVYVNGSLVGTHENPEELAEQIREARRRGEVSEMVNVSVRDRTGEVIVNADAGRARRPLLVVENGEPVVTQEEVEAVKNGDIDFEDLVEAGKVEFIDAEEEEDILVGVEEEELTTDHTHLEIDPQLIFGIGAGMIPYPEHNASPRITMGAGMMKQSLGLPAANYRIRPDTRQHLLHYPQKAMVNTQTTEQIGYDDRPAGQNFVVAVMSYEGFNIEDALVMNKGSVERALSRSHFFRTYEGEERRYPGGQEDRFEIPGDDVRGARGEDAYTHLDDDGLVNPETKVDDSSVLLGKTSPPRFLEEPEDMGGLSPQKRRETSVTMRSGEDGVVDTVTLMEGEDGSKLAKVSVRDERIPELGDKFASRHGQKGVVGHLAPQEDMPFTQEGVVPDLVLNPHALPSRMTVGHVLEMLGGKAGSLDGRSVDGTPFTGEGEDEIRGTLEDRGFKSSGKEVMYSGVSGEKIEAEIFVGTIFYHKLYHMVSNKLHARSKGPVQVLTRQPTEGRAREGGLRVGEMERDTVIGHGAAMVLKERLLDSSDREEIHVCGNCGMTAVENYEQRRVYCPNCEEETDVHSIEMSYAFKLLLDEMKALGIAPRLELEEAV
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo2C, DNA-directed RNA polymerase subunit B'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLGD_ECOK1
Sequence: MKVTFEQLKAAFNRVLISRGVDNETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTEDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL
What is the function of this protein?
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
What are the official names of this protein?
2,3-diketo-L-gulonate reductase, 2,3-DKG reductase, 3-dehydro-L-gulonate 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOZV_BACSU
Sequence: MVSKKNKIVAALLAFFFGGLGIHKFYLGRVGQGILYILFCWTGIPSIIAFIEFIIFLCGSEEGFDQKYNFYYFQQQSKA
What are the official names of this protein?
Uncharacterized membrane protein YozV.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUOK_ECOBD
Sequence: MIPLQHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS7_FRATO
Sequence: MSRRNRAPKRDILPDPKYKSQVVAKFVNHIMLSGKKSIAEKIVYGAFDKIKAKDASANEVEVFEKALESVSPMVEVKSRRVGGATYQVPVEVRPERRQTLGMRWIIDAARKRKENTMGDRLAAEILEAVEGRGAAVKKREDTHKMAEANKAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: FGF2_MOUSE
Sequence: MAASGITSLPALPEDGGAAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHVKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTEECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
What is the function of this protein?
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity).  Also acts as an integrin ligand which is required for FGF2 signaling (By similarity).  Binds to integrin ITGAV:ITGB3 (By similarity).  Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity).  Functions as a potent mitogen in vitro (By similarity).  Can induce angiogenesis (By similarity).  Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity).
What are the official names of this protein?
Fibroblast growth factor 2, FGF-2, Basic fibroblast growth factor, bFGF, Heparin-binding growth factor 2, HBGF-2.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism (By similarity). Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (By similarity). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity).
Protein: RNPA_CLOBA
Sequence: MIYRLKKNIEFIIVYRRGKSFANKTLVLYVLKNKRNKDKDGIAYSKVGISVSKKVGNSVVRSKCKRLLSESFRLNYNNILKGYDCVFVARNPMRDSDYFETEKAMKNLIKKAGLYYDEENGIKSN
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL30_STAAN
Sequence: MAKLQITLTRSVIGRPETQRKTVEALGLKKTNSSVVVEDNPAIRGQINKVKHLVTVEEK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RSM1_SCHPO
Sequence: MSFPTDMETNEILDQLDKIDERNEDILLKSLKASKCTYKPWSREEFLRRLLTYRSRWAYVNDPQIGEINCCLNGWLCESNNILVCDVCRNKINLTALQQVDAENDSLNELPEKTKERLEVSLKEEHQDNCLWRLHKFPPDIYHLSVSAELVQVGRRFNSLSTRLVSTHLPEEMTLKRLEKVANKIRVDWEKEDAAVLLGIALTGWSEQVPGRLYVCNYCHRRLGVWNLQSEGQDFDVLEEHKKSCPWVIPQPFTDLLGWQQIFELLCKESIFQSTTKTMDVSQYTDYTFSLLQGLR
What is the function of this protein?
Involved in the export of mRNA from the nucleus to the cytoplasm.
What are the official names of this protein?
mRNA export factor rsm1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL1_STRT1
Sequence: MAKKSKQMRAALEKIDSTKAYSVEEAVALAQETNFAKFDATVEVSYNLNIDVKKADQQIRGAMVLPNGTGKTQRVLVFARGAKAEEAKAAGADFVGEDELVDKINGGWLDFDVVVATPDMMAIVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGKITYRADKAGNVQAIIGKVSFEAEKLVENFKAFNDAIQKAKPATAKGVYITNLSITTTQGPGIKVDPNSL
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: KAPCA_HUMAN
Sequence: MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
What is the function of this protein?
Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation.
What are the official names of this protein?
cAMP-dependent protein kinase catalytic subunit alpha, PKA C-alpha.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Nucleus. Mitochondrion. Membrane; Lipid-anchor. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). Colocalizes with HSF1 in nuclear stress bodies (nSBs) upon heat shock (PubMed:21085490). SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Expressed in the midpiece region of the sperm flagellum (PubMed:10906071). Colocalizes with MROH2B and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm (By similarity).
Protein: TAM_MYCSK
Sequence: MWNPEAYLSFADHRGRPFFDLLARVGADAPRRVVDLGCGPGNLTVVLRHRWPEAVVEAWDNSPEMVAAARERGVQANLGDVRGWSPQPDTDVVLSNATLQWVPEHPELLTRWAGALAAGSWLAMQVPGNFDAPSHQAVRRLADREPWAPLLHDIPFRVGKVVETPADYAALLTDAGCSVDAWETTYIHELTDAHPVLEWITGTALRPVRSRLTDEQWDRFRAELIPLLDEAYPVRADGRTFFPFRRVFVVARTG
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_ECO8A
Sequence: MTLQQQIIKALGAKPQINAEEEIRRSIDFLKSYLQTYPFIKSLVLGISGGQDSTLAGKLCQMAINELRLETGNESLQFIAVRMPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQALREAGIELSDFVRGNEKARERMKAQYSIAGMTSGVVVGTDHAAEAITGFFTKYGDGGTDINPLYRLNKRQGKQLLTALGCPEHLYKKAPTADLEDDRPSLPDEVALGVTYDNIDDYLEGKNVPEQVARTIENWYLKTEHKRRPPITVFDDFWKK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: VPS10_CHAGB
Sequence: MRVRGALQAAAVLATALWATPLAAKKNDRPTFHTKAFENAPRSLNYFPDSDTVLFQDQSANNVYLSSDHGVKWERVDAVPEGKAWMLSMHGFDSNRAYILTEGTTHFRTSDRGKTWEKFKSGIQLSLFRPDILRFHANDPDRILFNGMICEGLDCQEVAQYTTDGFKTPAKELRRNTDGCWWAKSSDLFTTGAEDLDNNRVLCVVRDSFSPFKQDQRLLISDNFFRTSDDSSDIQEFEPDLDMNKPVQGVVSIAVVKKYLLVATTSMNTDEMALFITGDTKKWHRAVFPANHEGHDHRVLQEAYTALESTNYSIQIDVMTTRPSNPMGVMFTSNSNGTYFTENVPHTNRNERGHVDFEKVTGIQGVFLVNKVDNWEDVAKKASTKKKVVSEITFDDGRTFEPVTAGDKRIHLHSVTELSNVGPVFSSPAPGLLMAIGNRGDYLKNYWDDGNLYVSDDAGMTWNKALDGPHKYEFGDQGSILVAVRDSKEVDVSEISYSLDHGLTWTKQALPDDLKIRPYILTTTQESASLKFLLIGMVKESPSWQVISIDFDGLHEATCKEDDMEEWFARVDKDGKPTCLMGHTQSFPRRKKKAECFLKQEFKHPVSKTENCECTDKDYECDFNFAREDGKCVAKGPIIPPEGVCRDAKPDDTFKGTSGYRKILGNTCKETKEMDDKYKDVERKCSEIGGGGGGKPSTPATDKIEQIENVFDKDWDRWEKHYLERGESSSSEGETIIMRGRTKSKLGPIYVTENHGKEWHVPKYLKEEEIVHIVPHQYFKDMVFFITTGKKIIYTTDRGRTYHSFKAPNEPSDDVMPLSFHPDKKNWLIWNGKKCESSDDCFGVVSYSKDGGDHWQTGGSIYTRRCEFTGSRAYKYPGRKEEQILCLKHEKESKAKDNPMVLISTNDWFDNEEIRQKNVREFATMAEFVVVATENSANKTLQASASLDGATFADALFPHGFVVPHQHIYTVLDSSTHAVNLFVATSMDGNLCNYGSILKSNSNGTSYVVSVGNVNCDEDSYVDFDKIAGLEGVALVNVVANPDAESSAPKRLQTKITHNDGAQWAYLSTPPNDDIGKFPCQSSGDEKCALHLHGYTERRLRGNTWYSSESAVGIMVAWGNVGDSLGPRKDSDTFMTTDAGLTWKRVKQGQWTWAIGDQGGIIVLIQTTSVSRKKTKSLVYSLDQGKTWKEHEFASDEVEVWDVTTLRSGSSQNFLLWGKGSKGPFTLKLDFSGFSEDVCKVDDDPDKSDYYLWSPKHPMQPDGCLFGHVSQYLRKKSDRKCYNDFKLQPLYGKEDCKCTREDFECDYNYQLDPFGQCSLVPGLEPADPSAWCKQHPDEIEYHEPTGYRRIPLTTCVGGRQPDKESPVHACAGHEEDFERKHAVSGLALFFAITVPFALAGAAGWYVWRNWNGKFGQIRLGDQGAAVFEADRPWVRYPVIVLSAVAAVVVALPVVVGAVWRSVSGLLGGRGGAGGGDGRGRWSRLGGGGGGGGRRFTTRDSFARGGDYAVVDDDEGELLGEDSDEEV
What is the function of this protein?
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.  Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
What are the official names of this protein?
Vacuolar protein sorting/targeting protein 10, Carboxypeptidase Y receptor, CPY receptor, Sortilin VPS10, Vacuolar carboxypeptidase sorting receptor VPS10.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Protein: RSMH_SYNSC
Sequence: MPPFSHVPVLADAVLDAARRIPRPDGLLIDATLGGGGHSALLLEQHPGLRLIGLDQDATARAAAAERLASFGDRVSIVATNFADYVPPEPAVMVLADLGVSSPQLDVAERGFSFRLDGPLDMRMNAGGEGETAAELIDRLEENELADLIYGYGEERLSRRIARRIKADLKDRGSYDGTAALAYAVAGCYPPKSRRGRIHPATRTFQALRIAVNDELGVLDRLLQQAPDWLEPDGLLGIISFHSLEDRRVKTAFLRDERLQRITRKPVVATEQEEEANPRTRSAKWRVAQRLAAA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTCC2_STAES
Sequence: MKNIKKPFDLKGKSLLKEYDLTGEEFEGLIDFAMTLKKYKQQGTPHRYLEGKNIALLFEKTSTRTRAAFTVASIDLGAHPEFLGKNDIQLGKKESVEDTAKVLGRMFDGIEFRGFSQKTVEQLAEFSGVPVWNGLTDDWHPTQMLADYMTIKENFGYLKGINLTYVGNGRNNVAHSLMVAGAMLGVNVRICTPSSLTPRDVYFNIAKDQASNYGGSVKITDNIHTAVKDADVIYTDVWVSMGEESEFETRIHLLKDYQVNRKMLNLTGKVDTIFLHCLPAFHDTQTEYGQDIFKKYGLTEMEVTDEIFRSEHSRVFDQAENRMHTIKAVMAATLG
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase 2, catabolic, OTCase 2.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_CUPPJ
Sequence: MQDKYLPSAVEQAAQQHWQAIDAYRVPEHATGPDGKEKPKFYACSMLPYPSGKLHMGHVRNYTINDVMARYLRMNGNNVLMPMGWDAFGMPAENAALNNGVAPAAWTYDNIAYMKKQMQSMGLAIDWSREVATCSPDYYRWNQWLFLKMLEKGIAYRKTGTVNWDPVDQTVLANEQVIDGRGWRSGAIVEKREIPMYYLRITDYAEELLGDLDGLGWPERVKIMQQNWIGKSVGVRFAFKHDIEGDDGQLINDGKLYVFTTRADTIMGVTFCAVAAEHPLATHAAANNPELAAFIDECKHGSVMEADMATMEKKGMPTGLQVTHPLTGEQVDVWVGNYVLMSYGDGAVMGVPAHDERDFAFANKYKLPIRQVIDVKGQPYSTEAWQEWYGDKENGVCIESGKYNGLGYLAAVEAIAADLGAMGLGEKKITWRLRDWGISRQRYWGTPIPLIHCDSCGVVPVPEQDLPVVLPEDLVPDGTGNPLNKDPRFLQCSCPSCGKPARRETDTMDTFIDSCWYYMRYTCPDAATMVDARNDYWMPMDQYIGGIEHAILHLLYARFWTKVMRDLGLVKFDEPFTNLLTQGMVLNETFYREDAAGKKTWYNPADVDVQTDDRGRPVGATLKADGQPVVIGGVEKMSKSKNNGIDPQALIDQHGADTARLFVMFAAPPEQQLEWSGSGVEGASRFLRRVWNYGFANAAAVRDGAGAAPTADDADLRREIHGVLKQANYDYQRIQYNTVVSATMKMLNALEDAKNASPVARRECFGILLRVLYPVVPHITHGLWDALGYATQYGDLLDAPWPQVDEGALVRTEIEMVLQINGKVRGSVTVPADADRAAIETAAAASETVAKFAEGKAPKKIVVVPGRLVNVVL
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_PYRNV
Sequence: MLLAVPSKGRLQEPTLKLLEAVGIKPLASDERALVLPTSWPDVNLIKARPEDIPYLVESGRVWAGVTGHDYVLESGSNVVEALDLEFGRGRLVVAVPKSSGIKSVEELPPGARVATKFVNIAYNYFAELGKRVRVVKVTGSVEVLPQLGIADAILDVMATGTTLEVHGLTPIATVLETSARLVVHPEYTSHELTKKLVTFIKGYFAAQGKKMIFLNVPAARLEAVLSVLPAMEAPSVTKLAKGDIYEVFSVVSEDVLPDLVMKLKNAGAKDIVVTSIEKLIS
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPTN_CHICK
Sequence: MAGPCPLVEDSCSRLPSQSNVYGLAALPGAGGLLAATLKGKVLHFRYQHLRHKLRPVARELQFTYIPVDAEIVSIGCFQKSAPKRGLVVGITFIKDSGDKPSPFLNIYCDYEPGCEFDLDSVAQSCLNLELRFTPLQLCHAEVHIGDRCDTVFLLSGTDPGIHLYRENEGLHQFEEQPLHELFPELQELPSSALWLDVCTVPSSRRRLTAVGCQSGYVRVAHVDQDTRAVLQSWSIQQDGPISTVLLFPLEEPDDDGDVAGGHRGADDVGPSAPGPEPTPHYSLLVASTIEMSVVYRDVLSRGLTEQLSLPGSDHHDAVLCAMLACTALDGGREVLLGTYGQELLCYAYRGRRCGFQLLWTRRFPGPVLALCGADLTGDGLREVAVGCLQGLHVLQHSLEPTAQRLKERLRREVARRAQQRGGEGTGTPK
What is the function of this protein?
As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
What are the official names of this protein?
KICSTOR complex protein kaptin, Actin-associated protein 2E4.
What are the subcellular locations of this protein?
Lysosome membrane. Cell projection, lamellipodium. Cell projection, stereocilium. Note=Localization to lysosomes is amino acid-independent (By similarity). Colocalizes with F-actin (By similarity).
Protein: TRMD_LARHH
Sequence: MRIDAVTLFAPMFEALTRSGVTRRAAEQGIWSFHAWNPRDFTTDNYHTVDDRPYGGGPGMVMLCEPLQQALRQAVAAQQADGAARIRRIYLSPQGEQLTDRKVQELAGLDGLVLLCGRYEGVDERLLQSEIDEEISIGDYVLSGGELPAMVLMDAVVRRLPGVLNDAQSAEQDSFATGLLDCPHYTRPEVFDGVRVPDVLLSGNHAEIAKWRLKMALGRTRERRPDLLANRQLTKQEARLLAQYQQEHAPDNNRSSS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.