PharMolix/UniProtQA huggingface dataset:
Protein: MNMG_METSB
Sequence: MRVAFDVIVVGGGHAGCEAAAAAARMGAKTALLTHSRATIGIMSCNPAIGGLGKGHLVREIDALDGLMGRVADAAGIQFRVLNRAKGPAVRGPRAQADRALYRKAMRAALAETANLSIVEGEAADLRIENGEVTGIVTADGRALSCRAAVITTGTFLRGVIHRGKVTMAAGRIGENPAIRLGETLEARGFAMGRLKTGTPPRLDGKTIDWAGLDRQAPDPDPQPFSTLTASIVNPQIDCFITHTTVATHKVIRDNIGQSPVYSGAIGGRGPRYCPSIEDKVVRFEDRNSHQIFLEPEGLDDDTIYPNGISTSLPEEVQDAFLRTIPGLERVAVLQPGYAIEYDFIDPRELKSTLETKKLGGLFLAGQINGTTGYEEAAAQGLAAGLNAAARAGGGAPILFERSEAYLGVMIDDLVCRGVTEPYRMFTSRAEYRLSLRADNADQRLTGAGLKWGCIGMERSSAFRTKMAALQHARGLLEGFNLTPNEAAQHGLKINHDGVRRGAFELLALADTSLAKLQAIWPELREIEPSIAEQIEIDAKYAVYLDRQKRDIEAARRDEALLIPDSVDYDLLTGLSTEIRGRLRQIRPRSLAQASRIEGMTPVAMTLLAATVRRVGADSN
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_WOLPM
Sequence: MMSNTILPRNFYERPTLVVAGELLGKMLKFSNFSGIITEVEAYIGMSDPACHAAKGYTNRTSVMFGMPGFSYVYFIYGMYYCLNIVTEAEGFPAAVLIRGLKLIEPLEANLGGPGILCKRLNITKEHNKQDLTISHEFCVYESHLKPDYVCTPRIGISKGQEKFWRFKNLRSCVDYLPIG
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: IHFA_XYLF2
Sequence: MALTKAEMVERLFDEVGLNKREAKEFVDAFFDLLRDALEQGKEIKLSGFGNFELRCKNQRPGRNPKTGEEIPISARTVVTFRSGQKLKERVDAYVGSRQ
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: AROK_STRS2
Sequence: MPIVLLGFMGVGKTTTAHLLNLPVYDMDHIIEERIGMPIADYFSLEGEASFRQLETEVLKGLLDLPSNCIVSTGGGVIKSEVNRELLLANREDNVLLTASFEVSYQRIRKDRQSQRPLFLQCSKEEFEALYRERMALYQGLADTVIDTDKLIPEQVARKILCK
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3896_AERHH
Sequence: MKGLLARMHQQWQNLFPSAPSKGQHFEQLAERWLQARGLQPVTRNYRCRGGEIDLIMRQGETLVFVEVRYRSQTSHGGAAASVTRCKQHKIVLAARHYFKQHAINEASQACRFDVIAFEGDQPDWIQNAF
What are the official names of this protein?
UPF0102 protein AHA_3896.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: SEP11_MOUSE
Sequence: MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVSNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNPWLCTE
What is the function of this protein?
Filament-forming cytoskeletal GTPase.  May play a role in cytokinesis (Potential).  May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).
What are the official names of this protein?
Septin-11.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Synapse. Cell projection, dendritic spine. Cell projection, axon.
Protein: MED14_ASPCL
Sequence: MPGVVMDNATVGGPRRASESPDNVSSTPFPQERVNQSGDSGDRRNRSIFHNGAVKGAQGPGQHIETHTGKDGINESEGLPELAHITQGFFPFSTLVNRSVQQCWNDLSELVTELAAIQVSPHGQMPSTPANGKAPGDQSPENLQKKTRILDFAHAKRAEFIKLLVLSQWSRQAGDVSRLIDLQNFIRNRHQAFMDALQRIGDMKRDLVQAQVANPDLKTALEVLSKGRVVSITDLGYEAPKQLTAKGALKRLHKINRIISARLALHDTIPRPFRTYRVHDGRATFVVQGEFELDLSVGEESKSSQFFFVDIRFLFSPSSHVPKGRLSNELDVQVNDRLRDNGLKGCFDFLHGLVLTNKITILFKQAVELARGLWSDVLRVELLHRTLVVQYWALKLGAKSWIEIGIKSGRKPHDVKDSGVPYLALRWIRDGQEVDSTSVEFDADDLSMERLLRSIIALHISHLLSATYSILNQRSLFATGLLSLQALLNTNEPGKCQLLAQLTVSRHLRVSIEPMSGAIVLSADPSPLDRSESDSSLEKSSVDDIVSRVSRLRCIAALEEAESTVKILGFETVSPRGLKADVRKILPPNILRFALFWHPFWDRSWIVAATSSTDGDSWWVIHLRRPSALATSALNLDKDIHREATVCSGHVISNTFLAVQHLARDSSFADLSHCLSGMVAIHANASYLADLRSVAFQPPLRALKFESGLEVPNLLVRYQVSTLPRALQLVFPAGVGKKDFIRNTVRVAFHGIDQRRKVVIFVAYGNLLVPMKELSTLVSKLDGSLVFKQEGDSFAIRLLAPAGQPVIVQLFESLQRLECMLSIFEFLRRKKLVIRSLSLSQVAFAYGPRRSLAAVMDIGMSKLSNSEQLDPVDILARTDPLLLLRLGIRFDHSNPHRRIQGSLAAILNHTSNKAALDSVAEILSFTLPAMRTLDQITSNLSRGEPARLQVVVRNAFTFLLHYINYALRFELTASQHAGRLTWVLRESGDPQVGPGQDQIRAKLRDTLYNSNGNGWKGLGNGVVADVEGVCSVISNLDTSFAGARDNQETSGDVKPTERSLNQTDVKNHRDHDFDAQAAMDYDTSAVATNSAGARSSQQCDAPPEAADVITID
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NHAA_SHESH
Sequence: MERAIKNFLSQESAGGILLMIAVALAMIMANSPLSGMYQGFLDTEMQVRVGSLDIDKTLIHWINDGLMALFFMLIGLEVKRELLEGALSSAAQASLPTFAAVGGMVFPAGIYLLFNYGDPVTQAGWAIPAATDIAFALGVMALLGSRVPVSLKVFLLALAIIDDLGVVVIIAMFYSTDLSMLSLIVAGIAILGLVGLNRKGVTALGPYGVVGLILWIAVLKSGVHATLAGVIIAFCIPLRAKDGSSPSESLEHSLHPWSTFIILPIFAFANAGVDLSPMSFGDLLSPVPVGIALGLLLGKPLGVLVFSYIGVKLKMAVLPEGMGWKHIAPVALMCGIGFTMSMFISSLAFVGDAEAYGDFARLGILVGSFASAIIGYFWLAKVLPEVDVAKESKKGEIA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSLU_XYLF2
Sequence: MPSKTDFTSSTMTPREIVQELDRHIVGQQAAKRSVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIGRDLVDTAVKMYREQAKVRVRTQAEEYAEERILDALLPRRSVGIGFDADADAIRQEPSAHESETRAKFRRMLRSGELEEREIELDVAVNVSMDIMTPPGMEEMGQQLRQMFSNIGGGKSQKRKLAIKAARPLLIEEEAAKLVNEDEIRAAAIEACEQNGIVFIDEIDKVVKRGDTVGGGDVSREGVQRDLLPLVEGSNVSTKYGTIRTNHILFIASGAFHLTKPSDLIPELQGRFPIRVELDALSKADFIRILTEPKAALTKQYQELLKTEGVSLDFTEDAIDRIAEIAYLVNERQENIGARRLHTVLERLLETLSYESPDRDGESVTVDADYVNAHLGELVKDPDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_BURP0
Sequence: MKTSMQSKLDQLTTRLAELNDLLSRENVTADLDQYRKLTREHAEIGPVVEHYAQWRQARADELAAQELLADASMRDFAEDELRGARDRMGRLAAELQTMLLPKDPNDERNIFVEIRAGTGGDESALFAGDLLRMYLRYAERQRWQVEMMSESPSDLGGYKEVIVRIAGYGAYSRLKFESGGHRVQRVPATETQGRIHTSACTVAVMPEADEIGEVEINPADLRIDTFRASGAGGQHINKTDSAVRVTHIPTGIVVECQDDRSQHKNKDRALKVLAARIKDKQYHEQHAKEAATRKSLIGSGDRSERIRTYNFPQGRMTDHRINLTLYKLEQIMDGDLDELIAALVSEHQAELLASLGDAE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_BORGP
Sequence: MARSIKKGPFIEKSLYQKVLSSFGSEKRVVIKTYSRSSTIIPEMVSLTISVYNGKTFIPIYITEDLVGHKLGEFSPTRIFRGHAKSDKKGRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: MADA_MALRU
Sequence: MQKEKVWDKLSTDTEERMNAANELFSDRKVVPSQNGVALLEAVIRAGDRINLEGNNQKQADFLAECLGSCDSEKINNLHMVQSAVPLPIHLDIFDKGIAKKLDFAYGGPMAAKVAEFLREGKLELGAIHTYLELFARYFMDLTPRVSLICAYEGDKDGNLYTGFNTEDTPVIAEATKFRQGIVIAQVNKLVDKVQRVDIPGEWVDAVIESPKPFYLEPLFTRDPANITDTQVLMGMMALKGIYGEYGVQRLNHGIGFFTAAIELLLPTYGNELGLKGKICKHFALNPHPTMIPAIEDGWVESIHSFGGELGMQKYCEARPDIFFIGPDGSMRSNRAYSQTAGHYATDMFIGGTLQIDKYGNSSTATASRVAGFGGAPNMGCDAKGRRHVTDSWLKCGAEFEDQAALLGDMPRGKRLVVQMQETFKEKMDPSFVEKLDAWNLAKNANLDLAPVMIYSDDLTHIVTEEGIAYLAKCRGLEERMAAIRGVAGYTEVGLSADPKETKTLRERGIVKTPEDLGIDRSRANRSMLAAKSVKDLVDCSGGLYEPPARFVNW
What is the function of this protein?
Alpha subunit of the biotin-independent and biotin-dependent malonate decarboxylase multienzyme complex (EC 4. 1. 1. 88 and EC 7. 2. 4. 4, respectively).  Acts as an acyl-carrier protein (ACP) transferase component.  This first step in malonate decarboxylation involves the exchange of an acetyl thioester residue bound to the activated ACP subunit for a malonyl thioester residue.  Has a weak activity with acetyl-CoA as substrate.
What are the official names of this protein?
Acetyl-S-ACP:malonate ACP transferase, ACP transferase, Malonate/acetyl-CoA transferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_GRAFK
Sequence: MIERLNIVKQRFDEVNDLIIQPDVISDQKRYIELNKEYKDLRALMDEREKYISITDNIQEAEEIISDGSDPEMTEMAKLQLDEAKGQLPALEDKIRMMLIPKDPEDGKNIVMEIRAGTGGDEASIFAGDLYRMYTKYVEGRGWSHNIVDFSEGTSGGFKEMIFEVSGDDVYGTMKFEAGVHRVQRVPQTETQGRVHTSAATVMVLPEAEEFDVEIDPKEVRIDYFCSSGPGGQSVNTTYSAVRLTHEPTGLVAQCQDQKSQHKNKEKAFRVLRSRLYEMELAKKMEADAAKRNSMVSSGDRSAKIRTYNYAQSRVTDHRINLTLYDLSNIINGDIQKIIDELQLAENTEKLKENSDTI
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETD_PICAB
Sequence: MGATKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLSYIFPVVILGTIACTIGLAVLEPSMIGEPANPFATPLEILPEWYLFPVFQILRTVPNKLLGVLLMASVPAGSLTVPFLENVNQFQNPFRRPVATTVSLIGTAVALWLGIGAALPIDESLTLGLFQFDPTVEYKNLSIFYSYI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CYB_MARCA
Sequence: MTNTRKTHPLIKIINHSFIDLPAPSNISTWWNFGSLLGLCLVIQIFTGLFLAMHYTSDTLTAFSSVTHICRDVNYGWLIRYMHANGASVFFICLFLHVGRGMYYGSYTYFETWNIGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFVLPFIIAALVMVHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDILGVLLLILILMTLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILMLFPLLHLSKQRSMMFRPLSQCMFWILVADLFTLTWIGGQPVEYPYIIIGQLASILYFAIILLILPTISLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CLPP_STRMK
Sequence: MDNRTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDHMANVVVAQLLFLESENPEKDINIYINSPGGVVTAGMAIYDTMQYIKPNVSTTCIGQAASMGALLLAAGEAGKRYALPNSRVMIHQPLGGYQGQATDIDIHAREILTLRSRLNEVLAKHTGQSLETIARDTERDNFKSAFEAQAYGLVDQVLERRPDESIQAG
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_ECOUT
Sequence: MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQEALKESGLTAKDIDAVAYTAGPGLVGALLVGATVGRSLAFAWDVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVSGGHTQLISVTGIGQYELLGESIDDAAGEAFDKTAKLLGLDYPGGPLLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRDNGTDDQTRADIARAFEDAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTDNGAMIAYAGMVRFKAGATADLGVSVRPRWPLAELPAA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADI_SALAR
Sequence: MRQALPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVSELLARSEIPADAIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKALARVLVDVNKARTTRQRLTLFSRLRLRDLLPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAYRSHQRAAQAWAEGKLAEEVMTTYAPPYKNPFSEDNNIRGNSTLADYAKLRPAFDRKHGSVTAANSTPLTDGAAAVILMTESRAKELGLRPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMADLTLFDMHEAFAAQTLANLQLLGSERFARDVLGRAQATGEVDDTKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVTACAAGGLGAAMVLEAE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLA7_MACLB
Sequence: DQDCLPGWASHEGHCYKVFNLDKTWEDAEKFCTEQANSGHLVSIDSKKEANFVAELVSQNIKETRRTDFVWIGLRVEDKRQHCSSEWSDGSSINYQNWIEAESKKCLGLEKQTRYRKWVNFNCGQPYRFTCEI
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec A7, C-type lectin A7.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: RIBA_SHEPC
Sequence: MSIKYVATSKLPTPWGVFAMHGFEDTETGKEHVALTFGTLSADEPVLGRIHSECLTGDALFSLRCDCGFQLQTAMQNIAETGCGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQLGFPADMRKYDMIKPMLEQIGVKHVRLMTNNPRKVKAMKEFGIEVVERVPLQVGKNRYNEAYLKTKSTELGHMMSEYHFVDED
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: SECA_LACDA
Sequence: MANILKKLYNADKRELKRFEKIADQVESYADQMAALSDEELQAKTPEFRSRIEKGESLDDLLPEAFAVSREASKRVLGLYPFRVQILGGIALHRGNIAEMMTGEGKTLTATMPVYLNALSGKGVHVVTVNEYLSSRDETEMGQLYRWLGLTVGLNVSTMSPEEKRKAYACDVTYSTNSELGFDYLRDNMVVYKEQMVQRPLNYAIIDEVDSILIDEARTPLIISGEAEQANADYVRADRFVKKLVEDKSDNDADDDEDHGDYKIDWPTKTISLTRTGIQKACDHFGLKNLYDVENQKLVHHIDQALRANYIMLKDIDYVVQDGEVLIVDSFTGRVMEGRRFSDGLHQAIEAKEGVKIQEESQTQATITYQNYFRMYQKLSGMTGTAKTEEEEFREIYNMEVITIPTNRPVIRQDMPDLLYPTLDSKFKAVVDEIKERHAKGQPILVGTVSIESSERLSHMLDKEHIPHAVLNAKNHAKEAAIIMNAGQRGAVTIATNMAGRGTDIKLGPGVKELGGLAVIGTERHESRRIDNQLRGRSGRQGDPGYTRFYLSLEDDLMKRFGGDRVKDFLDRLSDNDDDKVIESRLITRQVESAQKRVEGNNYDTRKQTLQYDDVMRIQREIIYKERMQVIDEQQSLKSVLMPMIHRTIDHQVDMFTQGDRSTWRLDSLRDFIVSSLASEEYVDSEIDFKTFTPDALKQQLYQLVEDNYQEKEAALADPEQMLEFEKVVILRVVDEHWTNHIDAMDQLRQSIGLRGYGQLNPLVEYQDSGYNMFEEMISDIEFDVTRLFMKAQIRNNLSR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: ILK_RAT
Sequence: MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
What is the function of this protein?
Receptor-proximal protein kinase regulating integrin-mediated signal transduction.  May act as a mediator of inside-out integrin signaling.  Focal adhesion protein part of the complex ILK-PINCH.  This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway.  Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells.  Regulates cell motility by forming a complex with PARVB.  Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
What are the official names of this protein?
Integrin-linked protein kinase, 59 kDa serine/threonine-protein kinase, Beta-integrin-linked kinase, ILK-1, ILK-2, p59ILK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere.
Protein: QCR7_YARLI
Sequence: MASITSVVKTSELILKSPLLSKIVVPLAKTYVKFSGYRQLGFKMNDLIIEETPNMQLALRRLPPTESYDRVYRLIRATQFSLSHKLATGNDITKPEEDDHYLIPYILDVEAEAFEKDALDNLEVVKRK
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
What are the official names of this protein?
Cytochrome b-c1 complex subunit 7, Complex III subunit 7, Complex III subunit VII, Ubiquinol-cytochrome c reductase complex 14 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the UQCRB/QCR7 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: NDK_COXB1
Sequence: MAIERTLSIIKPDAVAKNVIGQIYSRFEKAGLKIISAKMCHLSKPQAEKFYAVHKDRPFYPDLVKFMTQGPVMIQVLEGENAIVKNREIMGATNPKEALPGTIRADFADSIDANAVHGSDGPETAKEEIAFFFKPDEIF
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB_FRACC
Sequence: MADPLGAAGRLPAVFMTPGTSSFADFLSRSAPHLLPGARSGLPGPVTEVAHGTTIVAVAFPGGVIMAGDRRATQGHMIAQRDVEKVHHADDYSCVGYAGTAGVGAELIRLFQVELEHYEKIEGSTLSLDAKANRLAAMVKGNLPMALQGLAVVPLFAGYDLDTGKGRIFSYDIAAAKSEERTYESIGSGSVFAKGSLKKRFRSDLSQDDAVRISVEALYDAADDDSATGGPDVIRKLYPIVAVVTADGYRRYADDEIEPVVTAIIADRSTNSGG
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PrcB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y188_METJA
Sequence: MSVKVSEYMTKKVVTVSKDNTVKDVIKLLKETGHNSFPVVENGKLIGIVSVHDIVGKDDNEKVENVMTKRKDMVVTTPDANIMDVGRIMFRTGFSKLPVVDEENNLVGIISNMDVIRSQIEKTTPKKLENIIKTYKSLGYNLRVEKEEVDVNKLRPTQNKIHADELVGRMYELKKGLAEPIIAIKTKRGDYYILVDGHHRAVAAYKMGVPKLDAYVIYLDTDKKLGIEKTAEIMNLKSLEDVKIVDSDDENSVKVIKYNKNGVLG
What are the official names of this protein?
Uncharacterized protein MJ0188.