PharMolix/UniProtQA huggingface dataset:
Protein: 6PGD1_ARATH
Sequence: MESAALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETLDRAAVEGNLPVSGQYSPRDFVLSIQRPRSLIILVKAGAPVDQTIDAFSEYMEPGDCIIDGGNEWYQNTERRISEAEQKGLLYLGMGVSGGEEGARNGPSLMPGGSFQAYDNIKDILEKVAAQVEDGPCVTYIGEGGSGNFVKMVHNGIEYGDMQLISEAYDVLKNVGGLSNEELAEIFTEWNSGELESFLVEITSDIFRVKDEFGDGELVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDCRYLSGLKDERENAAKVLREAGLKEEIGSASSGIDKKRLVDDVRQALYASKICSYAQGMNLLRAKSLEKSWNLNFGELARIWKGGCIIRAVFLDRIKKAYQRNPDLASLVVDPEFAKEMVQRQAAWRRVVGLAVSAGISTPGMCASLAYFDTYRRARLPANLVQAQRDLFGAHTYERTDRPGAYHTEWTKLARKNH
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Cytoplasm, cytosol.
Protein: LEU3_BURTA
Sequence: MKIAVLPGDGIGPEIVNEAVKVLNALDEKFELEHAPVGGAGYEASGHPLPDATLALAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASPLKPELVAGLDILIVRELNGDIYFGQPRGVRAAPDGPFAGEREGFDTMRYSEPEVRRIAHVAFQAAQKRAKKLLSVDKSNVLETSQFWRDVMIDVSKEYADVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDILSDEASMLTGSIGMLPSASLDKNNKGLYEPSHGSAPDIAGKGIANPLATILSAAMLLRYSLNRAEQADRIERAVKTVLEQGYRTGDIATPGCRQVGTAAMGDAVVAAL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_BUCAP
Sequence: MKIGIIGAIEQEIRKIKEIINNLKIKKIGNIKIYTGTFKKIEIFLILSGIGKVSASMSTTISINLFQPDFIINSGSAGSLNACLKIGDIIIPKKTCYYDVDLTNFGYSKGQIPEYPQTFKTNKNLREILKEIAVEFKFKFLTGLLVTGDSFIRKSNCIKKIKNQFSSAIGVDMESTAIGQVCHNFKIPFIIIKSISDLSDNNATSHFEKNIPIASLKSSKLVKLLLKKISSQNSI
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: DEN10_DANRE
Sequence: MATPELMLSLGLIEKDVNADTLWVWCYPSIDADLREVMLRKCCLTLDNQVLHTFVFGQFCRTWYYITTVEVQEPTVLKKVTHFSIVVTAKDFNPEKYAAFSRVLCRTYMKHGSPVKMMEGYIAVLTKGICQSDENGSFLIKDYDVRKALLAGSLKDVVSQFGMETIILYTALMLKKRVVVYHPRIEALLEFTRALPCLVWHRKDWSILHPFVHLENDELENLKVCTGYVAGFVDPEVKDRSDLFDVFVNLPDSEITVSQNAKEAMSMGKLHKEIGNFIVQAAEDADRSDAQVIKDISVKTKEILSNLMSLADHADNSKLTLECLKQGHYPPATENFLFHLAAAEQLLKI
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) which may be involved in the regulation of late endocytic pathway homeostasis, including endosomal positioning, maturation and secretion.
What are the official names of this protein?
DENN domain-containing protein 10, Protein FAM45, Protein FAM45A.
What is the protein family that this protein belongs to?
Belongs to the DENND10 family.
What are the subcellular locations of this protein?
Late endosome.
Protein: NS1_INCAA
Sequence: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKDGELLFNGTILQTESPTMTPASVEMKGKKFPIDFAPSNIAPIGQNPIYLSPCIPNFDGNVWEATMYHHRGATLTKTMNCNCFQRTIWCHPNPSRMRLSYAFVLYCRNTKKICGYLIAKQVAGIETGIRKCFRCIKSGFVMATDEISLTILQSIKSGAQLDPYWGNEKPDIDKTEAYMLSLREAGP
What is the function of this protein?
Prevents the establishment of the cellular antiviral state initiated by host RIGI, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7.  Participates also in the up-regulation of the splicing of viral mRNAs.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza C viruses NS1 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: RN186_BOVIN
Sequence: MACLEIPQQPQLVCQKATPSDPAGCDGGPGGPTEGDLECLVCREPYSGVRPPKLLGCQHAFCAVCLKLLLCVQDDAWSIPCPLCRKVTAVPGGLVCTLRDQEKVLERLARPGLEVPLRPQGLANPATLTAGQPREAGEEEQDAVTTNRAAARRLAAHLLLLVLLIILILPFIYPGVIRWVLSFLETLALLLALLFCSHPGQQDGCMPTPRTLFCRERKPSEIASIS
What is the function of this protein?
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress.  Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis.  Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens.  Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR.  Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2.  Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction.  Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF186, RING finger protein 186.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MRAY_SOLUE
Sequence: MLYFLLYEQLHRYISPFRVFSYTTVRTAFASLTALFLCIALGPWLINKLREFQIGQYIREEGPKSHQKKAGTPTMGGVLIVISIVIPTLLWADLRYPYVWIALAGLLGYGWIGFLDDYAKVTKQRNLGLSGKRKLVYQFIMGFAFAASLLVMRAYGDFSTTMNIPFLKQFKPSLLMTSMMANPWTYVIGVAPFCIFVALVVVFYSNAVNLTDGLDGLAIGLMVIAAGALTVLAYAGGHAQLAQYLQLARNPRTSELTIFCGSMTGASLGFLWYNAHPAEIFMGDVGSLGLGGAMAVVAVLIKQEILLLFIGGIFVLEAFSVILQVGSYKLRHGKRIFKMAPLHHHFEALGWTESKIIARFWIAGLVLALFALTTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PA2A2_BOTBZ
Sequence: NLWQFEMLIMKIAKTSGFMFYSSYGCYCGWGGHGRPQDASDRCCFVHDCCYGKVTGVVVCGGDDPCKXQICECDRVAATCFRDNKYWFFPAK
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that induces significant edematogenic activity.  Shows mild cytotoxicity on Trypanosoma cruzi and Leishmania infantum.  Also inhibits ADP- and collagen-induced platelet aggregation.  Does not show myotoxic activity.
What are the official names of this protein?
Acidic phospholipase A2 braziliase-II, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y374_MYCGE
Sequence: MDRKIVVLDINTANFFNTTKDLEVWKNFFNFIQANNHQLVFMSSCWQQAVLYLLDLLSLDDVDIIAESGAIIWISKTNEFIYQSFLDSVSIDTIVHHAIITNSGVFAIGKSKISEEPNTTINYFISLEKYKQFKLIWLTEFDQTLKYQNFLKNLSEMDVSSIYVFSPQYHLDFQLMEHISSGQPKFHYSNFYNENFLFTSTKNSKFSALETYVKSKNCSLKDVHYLNVTEVPINNINQLASVVFLSKKQPDNDEEFNNPEISIVLKGICEQLMK
What are the official names of this protein?
Uncharacterized protein MG374.
Protein: SSB_ECO57
Sequence: MASRGVNKVILVGNLGQDPEVRYMPNGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVASEYLRKGSQVYIEGQLRTRKWTDQSGQDRYTTEVVVNVGGTMQMLGGRQGGGAPAGGNIGGGQPQGGWGQPQQPQGGNQFSGGAQSRPQQSAPAAPSNEPPMDFDDDIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: RECR_RHIEC
Sequence: MAKRVTGPEIEKLIQLLAKVPGLGPRSARRAALHLIKKKDQLLGPLSNAMGEAYDKVKICSRCGNVDTVDPCTVCTDTQRDQSVIIVVEDVSDLWALERAGAMNAAYHVLGGTLSPLDGIGPDDLNIRGLIDRVGEGGIRELIIAVNATVEGQTTAHYITDQLQGLDVKITRLAHGVPVGGELDYLDEGTLAAALRARTVI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: FLIT_ECO5E
Sequence: MNHAPHLYFAWQQLVEKSQLMLRLATEEQWDELIASEMAYVNAVQEIAHLTEEVDPSTTMQEQLRPMLRLILDNESKVKQLLQIRMDELAKLVGQSSVQKSVLSAYGDQGGFVLAPQDNLF
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HCP_BACTN
Sequence: MSMFCYQCQETAMGTGCTLKGVCGKTSEVANLQDLLLFVVRGIAVYNEHLRREGHPSEEADKFIYDALFITITNANFDKAAIIRKIKEGLQLKNELASKVTIANAPDECLWDGNEDEFEEKARTVGVLRTPDEDIRSLKELVHYGLKGMAAYVEHAHNLGYQSPEIFAFMQSALAELTRNDITMEELVQLTLATGKHGVSAMAQLDAANTNSYGNPEISEVNLGVRNNPGILISGHDLKDLEELLEQTEGTGIDIYTHSEMLPAHYYPQLKKYKHLAGNYGNAWWKQKEEFESFNGPILFTSNCIVPPRANASYKDRIYITGACGLEGAHYIPERKDGKPKDFSALIAHAKQCQPPTAIESGTLIGGFAHAQVVALADKVVEAVKSGAIRKFFVMAGCDGRMKSREYYTEFAEKLPKDTVILTAGCAKYRYNKLALGDINGIPRVLDAGQCNDSYSLAVIALKLKEVFGLDDVNKLPIVYNIAWYEQKAVIVLLALLALGVKNIHLGPTLPAFLSPNVKNVLIEQFGIGGISTADEDIMKFLS
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRDA_STRA3
Sequence: MVSLKTEIAGFSFDNCLMNAAGIYCMTKEELLAIENSEAGSFVTKTGTLEAREGNPQPRYADTDWGSINSMGLPNKGIDYYLDFVTELQDQDNSKNHVLSLVGLSPEETHIILKKVENSSYNGLIELNLSCPNVPGKPQIAYDFEMTDLILSEIFSYYQKPLGIKLPPYFDIVHFDQAATIFNKYPLAFINCVNSIGNGLVIDDETVVIKPKNGFGGIGGDFIKPTALANVHAFYKRLNPSIKIIGTGGVKNGRDAFEHILCGASMVQIGTALQKEGPEIFQRVSRELKEIMADKGYQSLEDFRGQLNYL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
What are the official names of this protein?
Putative dihydroorotate dehydrogenase A (fumarate), DHOD A, DHODase A, DHOdehase A.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPO_XENTR
Sequence: MEQAQSLFREGVLSHLEQLEALSYNLAVKQEKQRQEWAALRKNQELVLELRKKRDELKAKIERHKAEIQAFRGREEAGEDHGSAAGTSQQAMLELCVEELKGMLEMHWLTGISGKRTKKGVCVCISTAFEGAYLDSFHLDIALKPSVGISRHSVPPFIPLEQIAKEHLQTDLKKFLSVLFEHLNAYAGRKYQFQQLQSFPGGFVRDAQQGNSLHTVLTFGYNVRVEKQPFCLRAKLLYGGVTRSLPTEAVITCEDNRPSVQEKISSHSSLFCQNPLHRALECISSEDETLNHSSASLLGTHMF
What is the function of this protein?
Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
What are the official names of this protein?
Centromere protein O, CENP-O.
What is the protein family that this protein belongs to?
Belongs to the CENP-O/MCM21 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres.
Protein: Y1968_HAMD5
Sequence: MPSFDIVSEIDTQEVRNAVENATRDLSTRWDFRHVTARFEFDEKQKSIKVTSESDFQVKQMLEIISEKLAKRGIEGGALDISAEILHSGKTYSLDAKLKQGIESLKAKKLVKLIKDSKLKVQAQIQGEQVRVTGKSRNDLQAVMALIRTGDLGQPFQFNNFRD
What are the official names of this protein?
UPF0234 protein HDEF_1968.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: PG146_VACCW
Sequence: MDSTNVRSGMKSRKKKPKTTVIDDDDDCMTCSACQSKLVKISDITKVSLDYINTMRGNTLACAACGSSLKLLNDFAS
What is the function of this protein?
Plays a role in the maturation of immature virions to infectious particles.  May also participate in viral transcription.
What are the official names of this protein?
Protein OPG146.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG146 family.
Protein: XYLA_STRRO
Sequence: MSFQPTPEDKFTFGLWTVGWQGRDPFGDATRPGLDPVETVQRLAELGAYGVTFHDDDLNPFGSSDTERESHIKRFRQALDATGMTVPMATTNLFTHPVFKDRFTANDRDVRAYAVRKTIRNIDLAAELGAKTYVAWGGREGAESGGAKDVRDALDRMKEAFDLLGEYVTAQGYDLRFAIEPKPNEPRGDILLPTVGHALAFIERLERPELYGVNPEVGHEQMAGLNFPHGIAQALWAGKLFHIDLNGQSGIKYDQDCGSRRRPAGGVLVVDLLESAGYEGPRHFDFKPPRTEDFDGVWASAEGCMRNYLILKQPRPPSAPTRRCRRRASAPRVWTSWPSRPLADGLEALLADRTAFEDFDVEAAAARGMVRTPRPAGDGPPAGRARLTVAPRKR
What is the function of this protein?
Involved in D-xylose catabolism.
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCDA_FRASN
Sequence: MTASATRQRPEADLGTAEWLVCDGCRRMIYGRRFARGGHVCPECGWHARLTATQRIALLLDEGSVEVVDTPVTAADPLQFVDTRPYADRLRSARTSTGLTEAVVVARGRIEGCPVVTAVMDFRFLGGSLGAAVGEAITGACEIALRERTPLLLVTASGGARMQEGALSLMQMAKTAQAIGQLDEAGILTVSLITDPTFGGVAASFATLTDVIVAEPGARLGFAGARVIEQTIRQTLPPGFQTAEFLLEHGVVDLISPRGQLRPTLARLLGVATRRPGTAPVTPGDGHSAGDGRGAGDSRGASHGGDGVVRDPARLADRHPWEAVRLARRLGRPSTLDYIGALVEDWTELHGDRAATDCPAMVAGLGRLDGTPVVVIGTQKGHTATELAARSYGMPSPGGYRKAARVMRLAAKLGLPVITLIDTAGAHPGLEAEQNGQAVAIAENLRLMAGLPVPVVAVVTGEGGSGGALALAVANRVLMCANAIYSVISPEGCAAILWKDPAAGPDAAAALRVDARALLAAGIVDGVVPEPDGGADVDPLAATDALRAALTGALAELAPLDPPTLVTARRARFRRFGTPAPAGGAAPAPVVPAARPPLGAGRTHADLDDARRAS
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity).
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha, ACCase subunits beta/alpha, Acetyl-CoA carboxylase carboxyltransferase subunits beta/alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRYAA_BALAC
Sequence: MDIAIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVPSGMDAGHSERAIPVSREEKPSSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.  Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: G3P1_ECOLI
Sequence: MTIKVGINGFGRIGRIVFRAAQKRSDIEIVAINDLLDADYMAYMLKYDSTHGRFDGTVEVKDGHLIVNGKKIRVTAERDPANLKWDEVGVDVVAEATGLFLTDETARKHITAGAKKVVMTGPSKDNTPMFVKGANFDKYAGQDIVSNASCTTNCLAPLAKVINDNFGIIEGLMTTVHATTATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVLPELNGKLTGMAFRVPTPNVSVVDLTVRLEKAATYEQIKAAVKAAAEGEMKGVLGYTEDDVVSTDFNGEVCTSVFDAKAGIALNDNFVKLVSWYDNETGYSNKVLDLIAHISK
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase A, GAPDH-A, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCAM_XENLA
Sequence: MKMEESAAHFFEGTEKLLELWFSQQDASKGSGDLRDIPRFEWDKLLENVHCLIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYCGFDGIQNFFYSRKNFMKPNHQEYPHRNFHEEVEFLNQIFPNGAAYCMGRINSDCWYLYTLDIPDEYVISQPDQTLEILMSELDPEVMDQFYMKEGVTANDVTRVSGIRDLITGSVIDATMFSPCGYSMNGMKSDGTYWTIHITPEPDFSYVSFETNVSLTTYDDLISKVVDVFKPRKFVTTLFVNQSSKCRTTFSCAQKIEGFRRVDRQFAQFNDYNFVFTSFAKIQPQQS
What is the function of this protein?
Essential for biosynthesis of the polyamines spermidine and spermine.  Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: SELO_RHILW
Sequence: MTSTLQKNRAGAAFPFDNSYAGLPARFFAAQTPTAVAEPWLIKLNEPLAVELGLDVETLRRDGAAIFSGNLVPEGAEPLAMAYAGHQFGGFSPQLGDGRAILLGEVVDRSGRRYDIQLKGAGPTPFSRRGDGRAAIGPVLREYIISEAMFALGIPATRALAAVTTGEPVYREEVLPGAVFTRVAASHIRVGTFQFFAARGDTDGVRALADYVIDRHYPDLKDADNPYLSLYSAVSERQAALIARWLHVGFIHGVMNTDNMTVSGETIDFGPCAFMDNYDPATVFSSIDQHGRYAYANQPGIGQWNLARLGETLLPLIDEEPDGAVDKANAVIRAYGERFQAHWLAGMRGKIGLAGEEDGDLELVQALLSLMQAQGADFTLTFRRLSDLAGDAAAETAFAASFREPEACGPWLAQWRERLSRDPQTAAERATAMCRVNPAFIPRNHRVEQAIEAAVENGDFTLFEALLTVLAKPYEDQPGFAAYMEPPKPSERVLATFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: MURQ_CLOBL
Sequence: MTNISLDKLVTESRNENTKDIDRVETLEMLKMINDEDKKVAEAVEKELIHIAKAVDKIGESFLNGGRLIYVGAGTSGRLGVLDASECPPTYGVSYDLVRGIIAGGESAMFKAREGAEDSKKLCIKDLKNINFGKNDILVGIAASGRTPYVIGGLEYANGIGATTISVTCNPESEMSKIANISIAPVVGPEAITGSTRMKAGTAQKMVLNMLSTGAMVKTGKVYGNLMVDLKATNEKLVERAKRIVMQATGSKREQVEKILKETNFDVKLSIFMIESSLDKIKAKEILDKNKGYIVEAIKEIS
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: PR3CB_DANRE
Sequence: MNCTRVLQILNPRPMPSPIMPVDVAMRICLAHSPPLRSFLSSYEDCKSRNLVNQYKPLRSCISSKTEDDTANITWKSPETKAKKKVVFADSKGMSLTAVHVFKEFEEDLMLDLQFELSDLEDAIVGLKAEKEKNFSLGFPQPAADYLDFRNRLKKNLVCLENCIIQERSVTGTVKVSNVSFEKVVHVRITFDSWKSHTDIPCTYMNNVYGCEDVDTFSFSIDLPSFVAPHEQVEFCLSYKTHDMTYWDNNDGKNYKLVHTENDSSQASVIQNATTDFKAQGKRPDMEFDQFGSPRTSSGFFPEWQSWGHIENNTPYW
What is the function of this protein?
Acts as a glycogen-targeting subunit for PP1 and regulates its activity.  Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown (By similarity).
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 3C-B.
Protein: RL27_PSEPW
Sequence: MAHKKAGGSTRNGRDSESKRLGVKMYGSQVVKAGNIIVRQRGTQFHAGYGVGMGKDHTLFAKIEGVIKFEKKGEFNRRYVSIVAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: CAS1_CLOSS
Sequence: MPRISDRVTYIYVEHSKINRVDGSITVAESRGIVRIPASMIGILLLGPGTDISHRAMELLGDSGTSVAWVGEQGVRNYAHGRSLSHTSRFLELQAKLVSNTRSRLQVARKMYQMRFPEEDVSSLTMQQLRAKEGARIRKIYRKMSAEYGVDWNGRTYDPDDFEGGDPVNQALSAANVALYGLAYSAIAAMGLATGLGFVHTGHDLSFVYDIADLYKADITVPVAFEIASEYEEGDNVGKISRQKVRDKFIGGKLFATIVRDIQLLFGIKEEEQLNVEPLSLWDNREGNIKYGINYSNENED
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Acts as a dsDNA endonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endonuclease Cas1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endonuclease Cas1 family.
Protein: RL23_THEAC
Sequence: MKGDIIISPLSTEKTALMAEKENKLTLMVRRDANREMIKKEVEERFGVKVEGINVMITKKGKKAIVKLAKEYSAEEIAERIGVF
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: ALL10_CARMA
Sequence: APQPYAFGL
What is the function of this protein?
May act as a neurotransmitter or neuromodulator.
What are the official names of this protein?
Carcinustatin-10.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.