PharMolix/UniProtQA huggingface dataset:
Protein: IBB1_LATSA
Sequence: GDDVKSACCDTCLCTKSNPPICRCVDIRETCHSACNSCVCTASIPPQCRFCYK
What is the function of this protein?
Inhibits trypsin (IC(50)=6. 20 nM), neutrophil elastase (ELANE) and, to a lesser extent, alpha-chymotrypsin (IC(50)=3. 44 uM).
What are the official names of this protein?
Bowman-Birk type proteinase inhibitor 1, LSI-1.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: CAPP1_ARATH
Sequence: MANRKLEKMASIDVHLRQLVPGKVSEDDKLVEYDALLLDRFLDILQDLHGEDLRETVQELYEHSAEYEGKHEPKKLEELGSVLTSLDPGDSIVIAKAFSHMLNLANLAEEVQIAYRRRIKKLKKGDFVDESSATTESDLEETFKKLVGDLNKSPEEIFDALKNQTVDLVLTAHPTQSVRRSLLQKHGRIRDCLAQLYAKDITPDDKQELDEALQREIQAAFRTDEIKRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGIEERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAATMYFNQIEDLMFEMSMWRCNDELRARADEVHANSRKDAAKHYIEFWKSIPTTEPYRVILGDVRDKLYHTRERAHQLLSNGHSDVPVEATFINLEQFLEPLELCYRSLCSCGDRPIADGSLLDFLRQVSTFGLSLVRLDIRQESDRHTDVLDAITTHLDIGSYREWSEERRQEWLLSELSGKRPLFGSDLPKTEEIADVLDTFHVIAELPADSFGAYIISMATAPSDVLAVELLQRECRVKQPLRVVPLFEKLADLEAAPAAVARLFSVDWYKNRINGKQEVMIGYSDSGKDAGRLSAAWQLYKAQEELVKVAKEYGVKLTMFHGRGGTVGRGGGPTHLAILSQPPDTINGSLRVTVQGEVIEQSFGEEHLCFRTLQRFTAATLEHGMRPPISPKPEWRALLDEMAVVATEEYRSVVFQEPRFVEYFRLATPELEYGRMNIGSRPSKRKPSGGIESLRAIPWIFAWTQTRFHLPVWLGFGSAIRHVIEKDVRNLHMLQDMYQHWPFFRVTIDLIEMVFAKGDPGIAALYDKLLVSEELWPFGEKLRANFEETKKLILQTAGHKDLLEGDPYLKQRLRLRDSYITTLNVCQAYTLKRIRDPSYHVTLRPHISKEIAESSKPAKELIELNPTSEYAPGLEDTLILTMKGIAAGLQNTG
What is the function of this protein?
Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.  Contributes probably to the adaptation to inorganic phosphate (Pi) deprivation.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase 1, AtPPC1, PEPC 1, PEPCase 1, 107-kDa PEPC polypeptide.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCMA_HAES1
Sequence: MQNNHLQLEQLACQRGDKILFTDLNLDAKSGDFVQIEGHNGIGKTSLLRIIVGLSFPAKGKVRWNKIEINKNREEYQHNLLYLGHLAGIKPELSAWENLQFYQKIGNCRQSEELLWDILQKVGLLGREDLPAGQLSAGQQKRIALARLWLSNAALWILDEPFTAIDKQGVNVLTQLFEQHVENGGIVILTSHQEIPSNKLQKVRLDQYKFFDQGNMA
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYS_ECO45
Sequence: MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEVPLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGR_THESQ
Sequence: MKISKKRRQELIRKIIHEKKISNQFQIVEELKKYGIKAVQPTVARDLKEIGAVKIMDESGNYVYKLLDETPVIDPWKELKRNFKSFVESIDRAGNLIVIKTIPGTASGIARVIDRLDIDEIVGTLAGDDTIFVAVRDPESCEKIVEKLSSIL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_CLOBK
Sequence: MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLGICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAEKKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIGKQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGDISFLVQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGEVTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDKVSRRIVNEVKEVNRIVYDVTSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: HEL1_SCHPO
Sequence: MSDLLDDEFYEEEFENDLLDASEFEDEFDEDAEIDDDGFTVERKRRRAHSVSYRVVSVRDLRASLNEKINQLTSIIDLTREQVLGLYRYFKWNRERLLERYIDAPEESLQKAGVGLSGSKQREVVHHEGTCEICYDEGCLPFFSAECDHEFCLACYRQYLDSRISEGESVIQCPEESCTQIVSIQSITKVLDEKSLDRYHRLLDRSFVDDNDHLRWCPAPDCEFAIECHVTQASLSSVVPTVTCNCGKQFCFGCGHDNHQPTICPLVKIWLQKCQDDSETANWIHANTKECPKCSTTIEKNGGCNHMTCKKCKYEFCWVCLGPWTEHGNNWYTCNRYEEKSSTSARDSQSKSRASLERYLHYYNRFANHEQSAKLDHELYEHTHKRMTQMQVDSNLSWVEVQFLKNAVDILFQCRQTLKWTYAFAYYLARNNQTEIFEDNQRDLELAVENLSELCERPCQDCSLSVFKQRVLDKTVYVRSRRDVLLDDTARGLAEGRWEYVVDV
What is the function of this protein?
Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones.  Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase dbl4, DNA-break-localizing protein 4, Histone E3 ligase 1, RING-type E3 ubiquitin transferase dbl4.
What is the protein family that this protein belongs to?
Belongs to the RBR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes to DNA double-strand breaks (DSBs).
Protein: CDS1_ENCCU
Sequence: MAEERKDSEESPGTYSCSKTLRRRGEITPNGKVRYETTQNKAAGITKTNFFRRLVLSIVMISGFCWISVNDKIYSFGLIIFLTISIIREIIGITRKSDGRPFHLRTSIILGLAVPIYSYLVFPSIMMMYFSRVSKCFLRRLSFVCFYSYVAAFMCFVASLRKGRLKPQLGLFALIHLSTYTMAIAAKCAIFNLNKGRFWFVFPALLVISNDISAYVVGKSIGKRPLYRLSPKKTLEGFIGAFIFTTAVGFALGHLHVNSGFLRDADSEQFQKFMKFTVFGANVRVQSIYIHIIPFIFVASFVAPFSGFLASALKRAYKKKDFGEAISGHGGIADRMDCQVLIAIFASTYISSFIYTEERSVGSVFSLICRNFSHDEIMILIEMLNRRVESIRK
What are the official names of this protein?
Phosphatidate cytidylyltransferase, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL5_COXBR
Sequence: MVELQELYKKTITPTLQKEFGFKSVMAVPRLEKITLNMGLGEAVADKKVIERAMDDMIKISGQKPLITYARKSEAGFKIRAGWPIGCKVTLRRDRMYEFLKRLISIAIPRIRDFRGLSPKSFDGRGNYSLGIREQIVFPEIQYDKVDAIRGMDITITTTARTDEEGRALLKAFGFPLKDESR
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ENO_METM5
Sequence: MDDSFDIYEIKARQVLDSRGNPTVEAEVLTAGGGYGHTIVPSGASTGTFEAVELRDATEKYGGKSVLNAVSNVNDIIAQELIGEDARNQRLIDQIMINLDGTENKGNLGANAILAVSLAVAKAAADTASLPLYKYIGGCNAYVMPAPMMNVLNGGQHAGNALDFQEFMIMPVGADSFAEAVRMCAETYQSLKKVVAEKYGKDAVNIGDEGGFAPPVKTIDEALALLLEGVKRAGYEDEIVFTLDSAASEFYDEKSGSYIVAGEKVSTDKLIDIYKEMVAQYPIVSIEDPLFEEDFEGFTKATKELKGIQIVGDDLFVTNTKRLKKGIEMGASNSLLLKVNQIGTLSESIDAANMAFRNGYSLVVSHRSGESEDSTIADLAVALNSGQIKTGAPARGERTAKYNQLIRIEEELQISKYAGKDFKVPF
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: TBX40_CAEEL
Sequence: MIQQAQFNVQMAEEDRWLTQYPNMEMIVNNKGPKPIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKVRHATKKEQEIKYFLHPDGTKLGEELMKETIKFDTVRITNHKKFMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEVAQFFPVTVYNQESIGNWKSKFHKNATFENRLDGGNKRKNTNSREEPSSKRSKNETEIAVLDILQVASQSENYNESTNSGRLQNEISSSIHQFPSTSYQNQYPHAYPTVNTPPIYAQQFPAPFDEKQNQFYPKTDENLAPNCAQDASSLPNFAMNQKASFANQYPYHPYYHQYSQLDHGSPYQYMNNSINSDSSFQSSFSTENSYFDDNGNPIHYPYYPYK
What are the official names of this protein?
Putative T-box protein 40.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDH_AGRFC
Sequence: MARKKIALIGSGMIGGTLAHLASLKELGDIVLFDIADGIPQGKGLDIAQSGPVEGFNAKLSGASDYAAIEGADVCIVTAGVARKPGMSRDDLLGINLKVMEQVGAGIKKYAPNAFVICITNPLDAMVWALQKFSGLPKNKVVGMAGVLDSARFRLFLAEEFNVSVQDVTAFVLGGHGDTMVPLARYSTVGGVPLTDLVKMGWLTAERLEQIIQRTRDGGAEIVGLLKTGSAYYAPAASAIEMAESYLKDKKRVLPAAAHLSGQYGVDDMYVGVPTIIGAGGIERVIEIELNKEEEAAFQKSVGAVAGLCEACINIAPSLK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: CR3BA_BACTO
Sequence: MIRMGGRKMNPNNRSEYDTIKVTPNSELPTNHNQYPLADNPNSTLEELNYKEFLRMTADNSTEVLDSSTVKDAVGTGISVVGQILGVVGVPFAGALTSFYQSFLNAIWPSDADPWKAFMAQVEVLIDKKIEEYAKSKALAELQGLQNNFEDYVNALDSWKKAPVNLRSRRSQDRIRELFSQAESHFRNSMPSFAVSKFEVLFLPTYAQAANTHLLLLKDAQVFGEEWGYSSEDIAEFYQRQLKLTQQYTDHCVNWYNVGLNSLRGSTYDAWVKFNRFRREMTLTVLDLIVLFPFYDVRLYSKGVKTELTRDIFTDPIFTLNALQEYGPTFSSIENSIRKPHLFDYLRGIEFHTRLRPGYSGKDSFNYWSGNYVETRPSIGSNDTITSPFYGDKSIEPIQKLSFDGQKVYRTIANTDIAAFPDGKIYFGVTKVDFSQYDDQKNETSTQTYDSKRYNGYLGAQDSIDQLPPETTDEPLEKAYSHQLNYAECFLMQDRRGTIPFFTWTHRSVDFFNTIDAEKITQLPVVKAYALSSGASIIEGPGFTGGNLLFLKESSNSIAKFKVTLNSAALLQRYRVRIRYASTTNLRLFVQNSNNDFLVIYINKTMNIDGDLTYQTFDFATSNSNMGFSGDTNDFIIGAESFVSNEKIYIDKIEFIPVQ
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of Coleoptera.
What are the official names of this protein?
Pesticidal crystal protein Cry3Ba, 75 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryIIIB(a).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: SECA_SALPK
Sequence: MLIKLLTKVFGSRNDRTLRRMRKAVSLINAMEPEMEKLSDDELKAKTNEFRARIEKGESVESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALSGKGVHVVTVNDYLAQRDAENNRPLFEFLGMSVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKKVNKIIPHLIRQEKEDSDTFQGEGHFSVDEKARQVNLTERGLVLIEELLVQEGIMDEGESLYSPGNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTANGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHANEAGIVAQAGYPAAVTIATNMAGRGTDIMLGGSWQAEVAALEAPTEEQIAQIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVSDVSDTINSIREDVFKATIDAYIPPQSLEEMWDILGLQERLKNDFDLEMPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLESLKYEVISTLSKVQVRMPEEVEAMEMQRREEAERLAQMQQLSHQDDDAAVAADLAAQTGERKIGRNDPCPCGSGKKYKQCHGRLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: DDX46_MOUSE
Sequence: MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGSKTKKTENRSRSKEKAEGGDSSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGTEMEDEELDPLDAYMEEVKEEVKKFNMRSVKGGAGNEKKSGPTVTKVVTVVTTKKAVVDADKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQEGGQSESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTNKGRYKVL
What is the function of this protein?
Plays an essential role in splicing, either prior to, or during A complex formation.
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX46, DEAD box protein 46.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, Cajal body. Membrane; Lipid- anchor. Note=Present in Cajal bodies (CBs) and nuclear speckles.
Protein: LHPP_HUMAN
Sequence: MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQILKEQGLRPYLLIHDGVRSEFDQIDTSNPNCVVIADAGESFSYQNMNNAFQVLMELEKPVLISLGKGRYYKETSGLMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIGVEAHQAVMIGDDIVGDVGGAQRCGMRALQVRTGKFRPSDEHHPEVKADGYVDNLAEAVDLLLQHADK
What is the function of this protein?
Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine.  Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).
What are the official names of this protein?
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase, hLHPP.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MRP2_MOUSE
Sequence: MDEFCNSTFWNLSLLKSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLYRIYRSRTKRFAITKFYLAKQVFVVCLLILAAIDLSLALTEDTGQATIPPVKYTNPILYLCTWLLVLVIQHCRQCCIQKNSWFLSMFWILSLLCGIFQFQTLIRALLQDSKSNMTYSCLFFVSYGFQIVILILSAFSESSDSTHAPSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKDLQKARQALQRRLKKSQQSPEGTSHGLTKKQSQSQDVLVLEDSKKKKKKSEATKDFPKSWLVKALFKTFYVVILKSFILKLAHDILLFLNPQLLKFLIGFVKDPDSYPWVGYIYAILMFSVTLIQSFFLQCYFQFCFVLGMTVRTTIIASVYKKALTLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHLLWSSVLQIALSIFFLWRELGPSILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTPTLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLEQYLGSDDLDLSAIRHVCHFDKAVQFSEASFTWDRDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTHGIHFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPEGEATVDNDSEEEDGDCGLIPTVEEIPDDAASLTMRRENSLRRTLSRSSRSGSRRGKSLKSSLKIKSVNALNKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSLLFIVIFYVLNYVAFIGTNLWLSAWTSDSEKQNGTDNSPSQRDMRIGVFGALGIAQGIFLLSSSLWSIYACRNASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDTVGFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPWVTDKKPPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELLSNMGPFYLMAKEAGIESVNHTEL
What is the function of this protein?
ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes.  Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates.  Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification.  Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4.  Transports sulfated bile salt such as taurolithocholate sulfate.  Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors.
What are the official names of this protein?
ATP-binding cassette sub-family C member 2, Canalicular multispecific organic anion transporter 1, Multidrug resistance-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: NTE1_NEUCR
Sequence: MESLSNLGNAMSSVLSETTSTTATAILADPTEALSSVVALASDAVSKATSDVVPEHTPTSWFTIILWLLHRISSVLYFVIKLTTITTPTFLFNIFSTSLTVTMNATTLVLIMLFMMAGVTWVVRYRYLNMYSRLPPEPQRKEPAVDLFPETQEEGVKSGLASYFDEFLSAIKIFGYLERPVFHELTRSMQTRKLIAGETLNLEEEQGFCLVVDGMVEIFVKSARDGRRSSSGPSFESDDEEGFAPGRQRYQLLTEVRNGAPMSSLFSIMSLFTEDIQMHDTDDDDSPDPTPSAPGTAMPGYPMNANFQQSNDTLPSIPGTPLSDNHVMQRGMASAESLTMSPLAHDSSRIPSLSLVNTRPAVPRRPVPKRLNTTSAHPDIIARATVDTTIAIIPASAFRRLIKIYPKATAHIVHVILSRFQRVTLATAYNYLGLSGEVLQMERNILKHTVRQLPNHLRGDALDRLKEKFKRERERIGEKEVEKGIALHNAHAARRRRSAASLRKEVALQAYSKRRQSIVTATPAFGTRRERPSPDMPSPGDLLTNTQQLKSGPASQLDLARDATSPRPQRNLSPFSTPRNAHVSLDTREALDEDDMFRESVLECMFRAIGLTGNGSVNPDSTQASPRFVPTDQRRSRGGPGHTAFGFMDAFDPFDNDTESVTSCGFSSSSPVPNPQLLAHDMKDEVEIVFFPKGSVLVEQGERNPGLYYVIDGFLDICVPGDDSSHDLLQSSAKVDHGHDSATGADAFGANSSRFPEPNMNNNFGAEQKKGKQGRRSVALIKPGGLAGYVGTISSYRSFIDVVARTDVCVGFLPLASIDRIVDRYPIVMLTMAKRLTELLPRLLLHIDFALEWVQVNSGQVLFREGDESEAIYLVLNGRLRLVEDQKDGGMNVKAEFGQGESIGELEVLTESARTGTLHAIRETELVKFPRTLFNSLAQEHPNITIKISKIIAARMRAFIDDPSRMGLKDNVVRSYKSSSTLNLRTVAILPVTAGVPVVEFGNRLMNALSQVGPPNGATCLNQAAILNHLGKLAFNRMGKLKLSQYLADLEEKYGLVVYVADTNVNTPWTQTCITQADCLLFVGLADSSPEIGEYERFMLGMKSTARKILVLVHQERYSNPGLTRQWLKNRMWINGGHFHVQMAYTSNTVPIHPPTKRFGPSLKQRVQILQAEIQKYTSRKVRHVPFYSPDAPFKGDFHRLARRLCGKSVGLVLGGGGARGIAHVGIIRAMEEAGIPIDMVGGTSIGAFIGGLYARHADVVPIFGLAKKFAGRMASMWRFAFDLTYPSASYTTGHEFNRGIFKTFGKTQIEDFWLEYYCNTTNISKSRVEFHTSGYAWRYIRASMSLAGLLPPLCDEGSMLLDGGYIDNLTVSRMKSLGSDVIFAVDVGSLDDNTPQAFGDSLSGVWAFFNRWNPFSSVPNPPTLAEIQARLAYVSSVGELERAKTMPGCIYMRPPIDDYGTLDFGKFDEIYGVGYKYGQEFLQKLREQGVLPLVEETEAKKALRRTMAPRRASI
What is the function of this protein?
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho).  Plays an important role in membrane lipid homeostasis.  Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
What are the official names of this protein?
Lysophospholipase nte1, Intracellular phospholipase B, Neuropathy target esterase homolog.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PDE6D_CULQU
Sequence: MGTDDVAKSEKIREGFQINWLILRDADTGKILWQENKDFSCPDVEHEARVPIKILDLRAVSREINFSTVEAMENFRLDQKVLFKGRIMEEWFFEMGWVSPNTTNTWQSTIEAAPESQMMPAKVLNGNVTIETSFFDGETLISKSVVRLYYI
What are the official names of this protein?
Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the PDE6D/unc-119 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: TICN2_MOUSE
Sequence: MRAPGSGRLALPLLLLAVVALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNRFRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCVAQGYQRAMCISRKKLEHRIKQPSLKLHGGKDSVCKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPCPCPTEQSTASTTDSKSETCTGQDLADLGDRLRDWFQLLRENSKQNGSANSATNPAGLDKSLGASCKDSIGWMFSKLDTSGDLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTAEWCFCFWREKPPCLAELERTQIQEAAKKKPGVFIPSCDEDGYYRKMQCDQSRGDCWCVDQLGLELTGTRMHGTPDCDDIVGFSGDFGSGVGWEDEEEKETEEAGEEAEEEEGEAGEADDGGYIW
What is the function of this protein?
May participate in diverse steps of neurogenesis.  Binds calcium (By similarity).
What are the official names of this protein?
Testican-2, SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PUR7_CAMC1
Sequence: MQKRELIYEGKGKKMYATDDPNLLVAEFKDDLTAFDAQKRGNEAGKGALNNKISTQLFKLLESKGIVTDLVETISDTEQVVKKCEIIPLEVVVRNIATGSLSKRLGIKEGTVLPFTLVEFYYKNDDLHDPLVTDEHCIIMGLVKSEKDLQTLRHTAREINSILFKFFAERNLKLVDFKVEFGIDKDGNIILADEISPDSCRFWDATTNEKLDKDRFRQDLGSVKVAYEEVLRRILS
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: GCNA1_CAEEL
Sequence: MPTPFRDLHNKSNASASSYETAWSSSFSSRRSTNNDSKSNLKEIKDEPISNLDESISILENNISMMSVSSPTPAYRTPARVIAREAPMTPGDRLLQKIEKEDERDMLRQLYPEMFDSNQKPRQKPKEVKKALKVESLSDYENDDKENVPPCGKPSKEKEEKKQRTKKIVISSDSEDDGNFENYLKTLREKPTEPAKPERKIPVKKDFVVDDDYISEESSEEESEEEEEDVDDEEYRESSPEVEAKISYSDRKQKKRPTDEEEWFLLSLSEKFSGPIHEDAKVYIKETSLRYKKHRESLLTRLQDILVRRIFSAIPSEKLKVIWNARLRKSAGQCRNHSNGNSTVEMSPVVCTTAERVRDTLIHELCHAATWVVDRLHKEGHGPGWKRWGARCSSVFKSLPFIERCHSYEIEAKFFYVCEKDGCDVEIKRQSKSLDTSRKACGRCFGRFILYRYCRRTNTRIRIEDPKAKPVGPILSNSSKPSPPAPRRIVSEHPEGFKEYSEEHYWKYTAQGLKHSDVMGKLLKEFKELKQL
What is the function of this protein?
May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:30914427, PubMed:31839537, PubMed:31839538).  May resolve the topoisomerase II (top-2) DPCs (PubMed:31839537, PubMed:31839538).  Limits replication stress and DNA double-strand breaks (PubMed:31839537).
What are the official names of this protein?
Germ cell nuclear acidic-1 protein, Germ cell nuclear acidic-1 peptidase.
What is the protein family that this protein belongs to?
Belongs to the serine-aspartate repeat-containing protein (SDr) family.
What are the subcellular locations of this protein?
Chromosome. Note=Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (PubMed:31839538). Colocalizes with top-2 on condensed chromosomes during embryonic cell divisions (PubMed:31839538).