PharMolix/UniProtQA huggingface dataset:
Protein: HISN_MYCTU
Sequence: MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLIALLEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFSSLSGWARPGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGGSAVATNGLLHDEVLTRLNAG
What is the function of this protein?
Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine.
What are the official names of this protein?
Histidinol-phosphatase, HolPase, Histidinol-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
Protein: LEPH_STAAR
Sequence: MKKVVKYLISLILAIIIVLFVQTFVIVGHVIPNNDMSPTLNKGDRVIVNKIKVTFNQLNNGDIITYRRGNEIYTSRIIAKPGQSMAFRQGQLYRDDRPVDASYAKNRKIKDFSLRNFKKLDGDIIPPNNFVVLNDHDNNQHDSRQFGLIDKKDIIGNISLRYYPFSKWTIQFKS
What is the function of this protein?
Catalytically inactive.
What are the official names of this protein?
Inactive signal peptidase IA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: T5AT_TAXCU
Sequence: MEKTDLHVNLIEKVMVGPSPPLPKTTLQLSSIDNLPGVRGSIFNALLIYNASPSPTMISADPAKPIREALAKILVYYPPFAGRLRETENGDLEVECTGEGAMFLEAMADNELSVLGDFDDSNPSFQQLLFSLPLDTNFKDLSLLVVQVTRFTCGGFVVGVSFHHGVCDGRGAAQFLKGLAEMARGEVKLSLEPIWNRELVKLDDPKYLQFFHFEFLRAPSIVEKIVQTYFIIDFETINYIKQSVMEECKEFCSSFEVASAMTWIARTRAFQIPESEYVKILFGMDMRNSFNPPLPSGYYGNSIGTACAVDNVQDLLSGSLLRAIMIIKKSKVSLNDNFKSRAVVKPSELDVNMNHENVVAFADWSRLGFDEVDFGWGNAVSVSPVQQQSALAMQNYFLFLKPSKNKPDGIKILMFLPLSKMKSFKIEMEAMMKKYVAKV
What are the official names of this protein?
Taxadien-5-alpha-ol O-acetyltransferase, Taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase, Taxadienol acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: SSED_SALTY
Sequence: MEASNVALVLPAPSLLTPSSTPSPSGEGMGTESMLLLFDDIWMKLMELAKKLRDIMRSYNVEKQRLAWELQVNVLQTQMKTIDEAFRASMITAGGAMLSGVLTIGLGAVGGETGLIAGQAVGHTAGGVMGLGAGVAQRQSDQDKAIADLQQNGAQSYNKSLTEIMEKATEIMQQIIGVGSSLVTVLAEILRALTR
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  May act as a translocator that mediates translocation of SPI-2 TTSS effector proteins from intraphagosomal bacterial cells into the host cells.
What are the official names of this protein?
Secreted effector protein SseD, Secretion system effector D.
What are the subcellular locations of this protein?
Secreted. Cell surface. Note=Secreted via type III secretion system 2 (SPI-2 TTSS). After secretion, localizes mainly on the surface of the bacterial cell.
Protein: IF2_BACC3
Sequence: MSKIRVHEYAKKHNISSKDLMTKLKEMNIEVSNHMTMLDDEVVNKLDNEYQAEKPSVADEFEVEEKVVRSKKNSNKKKKKGKGNEDKRQENFAGRQQTQTVETPDKITFSGSLTVGDLAKKLSKEPSEIIKKLFMLGIMATINQDLDKDTIELIANDYGIEVEEEVIVSETEFETFIDEQDDEENLKERPAVVTIMGHVDHGKTTLLDSIRNSKVTAGEAGGITQHIGAYQVEVNDKKITFLDTPGHAAFTTMRARGAQVTDITILVVAADDGVMPQTVEAINHAKAAGVPIIVAVNKMDKPAANPDRVMQELTEYELVPEAWGGDTIFVPISAIQGEGIDNLLEMILLVSEVEEYKANPNRYATGTVIEAQLDKGKGTIATLLVQNGTLRVGDPIVVGTSFGRVRAMVSDIGRRVKVAGPSTPVEITGLNEVPQAGDRFMAFADEKKARQIGESRAQEALLAQRGEKSKLSLEDLFQQIQEGDVKEINLIVKADVQGSVEAMAASLRKIDVEGVKVKIIHTGVGAITESDIILASASNAIVIGFNVRPDVNAKRTAELENVDIRLHRIIYKVIEEIEAAMQGMLDPEFEEKVIGQAEVRQTFKVTKVGTIAGCYVTDGKITRDSGVRIIRDGVVIFEGQLDTLKRFKDDVKEVAQNYECGITIERYNDLKEGDIIEAYIMEEVKR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K2012_HUMAN
Sequence: MFTLSLLSRGHGKLGQDKQKLEVYFEPEDYLNWRSPEDYVPVSKPQDKNNASQHSWSLFLPKTFSTRKGALILYSEGFAISAWTPKERRKGPYCPRGPWRKLDLELHTLQDLKEAILAYGRQQGEQDRAWQPYLHFRSQLESQAQRQIQPGHSAKRYLRGLLRTWPPDAMYRLWCAGYIKDSVLLQDSQLNVPKKLRPQQDLSGVPPKYHLLPVFPSFWIQQGKSFEQRQQGLDEGEAGAAGHVDQGPLAKNHGSQGTRLPPRRKQPWQEDETQAEDTSIENHLCLYASKESYNEKTQQTSRKAFGHGRIDHSWLPSDKSHITFCGGAFPNRKADLSDKQRNVKLHKARSSHLLQVLPAERSLFPPVASATGSRIITPGEVKKKKAPKALKLPPISEEPPRVLEPLKSQFKANEPPTELFILPVEIHYHTKQPPKEKAHRRGAPHPESEPESSEESTPVWRPPLKHASLETPWELTVHLPVDASRDTLSPQGSSSLPPASLGNLTLKGSKARHTRVHSQGKGVWKGDDDAPPHDVAPPLDLLPPIKGKKSPESQKGVDSPRTSDHNSPPSLPNMRVPRRALPAAQEDSSDPTLGHFLLGPDGEKVCLSLPGHTQTEALPSGKAYESVNSNISHEEEGPSSQHFLKANTEPRANLHMNLYETSPLTQTTEKQGAQQSLEAAAQKTGEPQSCINKALICSNRKEFYTRKLHIDMTPFLKESGNALDYQEEAGRPLRETHHNDQDPEPRSMTLDSPRASRTEHIQTPEADIVQKVGRDYDVHHLHRGLLGYGPESPERLSAVYTSLLPREREGKAEPRLFSQETSANISHERDLINEAKRKEKPKKDKTKGPKSEREGKVYGQAEAAIGKSKDSKAKKKLEKKTRPQRKRTQKERNLEIAAELSGPDVSYEETEDTSNRGSFASDSFVEDPWLSPKYDAQESQVSLDGRSSPSQIATVTGNMESKEERRCEDPSKALLTKREQEKASWDRLRAERAEMRWLEVEKKRREQEEQRQLQQEQLERAKKMEEELELEQQRRTEEIRLRKQRLQEEQQRQEEEERKQQLRLKAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLMEMAEEERLEYQRRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQARYWIFGQQLP
What are the official names of this protein?
Uncharacterized protein KIAA2012.
Protein: Y1445_STAAN
Sequence: MENFDKTMKFDYEELPTQDVRDVLNNVYRTLDERGYNAVNQIVGYLLSGDPAYIPRQNEARNQIRHIDRDVIMEELVSYYLKEQNK
What are the official names of this protein?
UPF0297 protein SA1445.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: YBFE_SHIFL
Sequence: MAKEQTDRTTLDLFAHERRPGRPKTNPLSRDEQLRINKRNQLKRDKVRGLKRVELKLNAEAVEALNELAESRNMSRSELIEEMLMQQLAALRSQGIV
What are the official names of this protein?
Uncharacterized protein YbfE.
Protein: CDX2_MESAU
Sequence: MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWSTAYGAPLREDWNGYPPGGAAAANAVAHGLNGGSPAAAMGYSSPADYHAHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATGAAEQLSPSGQRRNLCEWMRKPAQPSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQQQQQLASPPPQPSQPQPGSLRSVPEPLSPVSSLQGSVPGSVPGVLGPAGGVLNPTVTQ
What is the function of this protein?
Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (PubMed:1358758).  Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity).  Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity).  Binds to and activates transcription of LPH (PubMed:9148757).  Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity).  Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity).  Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.  Binds preferentially to methylated DNA (By similarity).
What are the official names of this protein?
Homeobox protein CDX-2, Caudal-type homeobox protein 2.
What is the protein family that this protein belongs to?
Belongs to the Caudal homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SHE9_VANPO
Sequence: MDTLHGELVLGMMNRIVCRGNLLKSSFYSSSRIGYSSIYDTGSIRSFTSTGILSNSKSKLTGGGNVDGNKGNNGNEDLLKGFKSKLDHSKDLFSKYKSLLVKNIDNVKEAIREANRKFAEQEAQAGVDSKLSYNKDVSTGGVIGGLPSEREIRRRKWSRRLEFYLDSLQETIFSASKAFNDVTGYSSIQKLRKSIDLLQIQLEVMKRELKTLRVDYEESIEKRINSQRQVNELLQRKSSWSATDLENFTQLYKDDATNSKREQDLKTELKNKEEAQEKITDELYSAILTRYHEEQIWSDKIRRTSIWSTFMLMAVNLFLFVILQLFLEPWKRRRLVRAFERNVRTSLEAQAADHQLHYEQLNAQLQEQSRLIQQELEMEKFKDDKRKQDEPQTPSTIWGWFLQLINKLQNLSPMDMNCQTNFNTLQIYLLVTSVGVISSILTTLIS
What is the function of this protein?
Required for the maintenance of the structure of the mitochondrial inner membrane.  Involved in mitochondrial morphology.  Causes growth arrest when highly overexpressed (By similarity).
What are the official names of this protein?
Sensitive to high expression protein 9 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the SHE9 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TRPB_DECAR
Sequence: MSQYNFPDAKGHFGPYGGVFVAETLFGALDELKEAYAAAQADPAFRAEYEYELKHFVGRPSPIYHAKRWSEMLGGAQIYLKREDLNHTGAHKVNNCIGQAMLAKRMGKPRVIAETGAGQHGVATATVAARYGMECVVYMGSEDVKRQAANVYRMKLLGATVVPVESGSKTLKDALNEAMRDWVTNIHNTFYIIGTVAGPHPYPMLVRDFQKIIGEECLVQMPEMTGRQPDAVIACVGGGSNAMGIFYPYINVEGVRLIGVEAAGDGMETGRHSASLTAGVPGVLHGNRTYLLQDEDGQIIETHSVSAGLDYPGVGPEHAWLKDLGRAEYQPVTDSEALAAFHTLCRIEGIIPALESSHALAYAAKLAPTLAKDKILLVNLSGRGDKDMHTVAEKSGIVF
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: CH602_CHLAA
Sequence: MAKQLIFDQQARTALKHGIDTLALAVKTTLGPRGRNVALDKKWGAPTVTHDGVSVAKEIELKDPFANLGVQLLKQAAVKTNDVAGDGTTTATVLAQAIINEGLKLVAAGANPMLLKRGLDKGGQALVARIKEQAITLKTRDEIRNVATISAQDAEVGELLATVMDKIGRDGVVTVEEGKSTHLEHELVEGMQFDRGYISPYFITDSARMEAVLDEPYILITDKKISAIKDLLPILEAVLSSGKKDLLVIAEDVDGEALATLVVNKLRGTLNALAVKAPGFGDRRKAMLQDIAILTGGTVISEEIGRKLESATLQDLGRARRVKADKDNTVIVEGHGDKQAIQARIAQLKQQIETTTSDYDREKLQERVAKLSGGVAVIKVGAPTEPAMKERKARVEDALNATRAAVEEGIVPGGGVALLNAIPALDNVTTQFEEERMALNVLRRALEEPLRQLATNAGEDGSVVVENVRNEQRKHNNNHYGYDVMTGTYVDLMQAGIIDPAKVVRSALENAISVAGMVLTTEALIVDAPEPKKKNGTPPMPDDDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA_STUS1
Sequence: MPTSRPFVLTPGEPAGIGPDLCLLLARQAQPRPLVAIASRALLAQRAEQLGLSIELRDAGPQDWPGEPAPANCLYVWDTPLATAVTAGQLDPRNAHYVLETLTRAGRGCLDGSFAGIITAPVHKGVINEAGIPFSGHTEFLAELTLTEQVVMMLATRGLRVALVTTHLPLRDVAEAITAERLQRVTRILHADLVSKFGIARPRILVCGLNPHAGEGGHLGREEIEVIEPTLAGLREEGIELIGPLPADTLFTPKHLEHCDAVLAMYHDQGLPVLKYKGFGAAVNVTLGLPIVRTSVDHGTALDLAGTGRVDIGSLQVALETAYQMSGAA
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
Protein: PFL_LACLA
Sequence: MKTEVTENIFEQAWDGFKGTNWRDKASVTRFVQENYKPYDGDESFLAGPTERTLKVKKIIEDTKNHYEEVGFPFDTDRVTSIDKIPAGYIDANDKELELIYGMQNSELFRLNFMPRGGLRVAEKILTEHGLSVDPGLHDVLSQTMTSVNDGIFRAYTSAIRKARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMKEKAKEWDAITEINEENIRLKEEINMQYQALQEVVNFGALYGLDVSRPAMNVKEAIQWVNIAYMAVCRVINGAATSLGRVPIVLDIFAERDLARGTFTEQEIQEFVDDFVLKLRTMKFARAAAYDELYSGDPTFITTSMAGMGNDGRHRVTKMDYRFLNTLDTIGNAPEPNLTVLWDSKLPYSFKRYSMSMSHKHSSIQYEGVETMAKDGYGEMSCISCCVSPLDPENEEGRHNLQYFGARVNVLKAMLTGLNGGYDDVHKDYKVFDIEPVRDEILDYDTVMENFDKSLDWLTDTYVDAMNIIHYMTDKYNYEAVQMAFLPTKVRANMGFGICGFANTVDSLSAIKYAKVKTLRDENGYIYDYEVEGDFPRYGEDDDRADDIAKLVMKMYHEKLASHKLYKNAEATVSLLTITSNVAYSKQTGNSPVHKGVFLNEDGTVNKSKLEFFSPGANPSNKAKGGWLQNLRSLAKLEFKDANDGISLTTQVSPRALGKTRDEQVDNLVQILDGYFTPGALINGTEFAGQHVNLNVMDLKDVYDKIMRGEDVIVRISGYCVNTKYLTPEQKQELTERVFHEVLSNDDEEVMHTSNI
What are the official names of this protein?
Formate acetyltransferase, Pyruvate formate-lyase.
What is the protein family that this protein belongs to?
Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_BACHK
Sequence: MKIALIAHDKKKDDMVSFAYAYKPIFEQHELFATGTTGLRIMEATGLVVTRYQSGPLGGDQEIGAMIAKNDLDMVIFFRDPLTAQPHEPDVNALLRLCDVYAIPLATNMASAEMLMHALERGDLDYRKLRK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: PR1_FOEVU
Sequence: GVQKSEVVITSA
What are the official names of this protein?
Pathogenesis-related protein, PRP.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: PURA_SALRD
Sequence: MPVSIVIGSQWGDEGKGKIVDLLSPDVDIVARYQGGANAGHTIVWDEEGETEEFVLHLVPSGIFHEGVTCVIGNGVVLDPKAILEEIEKIESLGIDVEGRLKISHNAHLIMPYHKAIEAAQEEDRASASDDDEIGTTGRGIGPAYTDKFARTGIRVVDLLDEDVLRRKLRRSIEEKNAILRDVYDAEALDVDRIVEEYVEFDQKIDDYVTDTSAYLSRALDDGARVLAEGAQGSLLDVDFGSYPYVTSSHPTAGGCCTGLGVSPTEIDRVLGIAKAYCTRVGNGPFPTELDGEVGQALREKGGEFGATTGRPRRCGWLDLVALRYTCMVNGFNELALTKLDILSGIDELKVCTEYRYDGKTTRRFPSEPQNLTRVEPQYETLPGWEADISAVRHVDDLPRAAQDYLAFIENYLDVEIGLVSNGPRRSQIITDVQPMAAA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1433B_CHICK
Sequence: MDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGREYREKIEAELQDICNDVLELLDKYLIVNATQPESKVFYLKMKGDYYRYLSEVASGDNKQTTVANSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACNLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner (By similarity).
What are the official names of this protein?
14-3-3 protein beta/alpha.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SARD_BILW3
Sequence: MAFVHYTVKKIVHGLGAIKEAANEVKNLKGSKAFIVTDPGLAKIGVQKPLEEALTAGGIEWKLYAEAQLEPSMDSIQHCTDEAKAFGADVIIGFGGGSALDTTKAASVLLSNEGPIDKYFGINLVPNPSLPCILIPTTSGTGSEMTNISVLADTKNGGKKGVVSEYMYADTVILDAELTFGLPPRVTAMTGVDAFVHAMESFCGIAATPITDALNLQAMKLVGANIRQAYANGKNAAARDAMMYASALAGMGFGNTQNGIIHAIGTTLPVECHIPHGLAMSFCAPFSVGFNYIANPEKYAIVADILRGDDRSGCMSVMDRAADVEDAFRDLLNDLDIATGLSNYGVKREDLPACADRAFAAKRLLNNNPRAASRDQILALLEANFEA
What is the function of this protein?
Involved in an anaerobic respiration pathway that converts the sulfonate taurine (2-aminoethanesulfonate) to ammonia, acetate and sulfide.  Catalyzes the NADH-dependent reduction of sulfoacetaldehyde to 2-hydroxyethane-1-sulfonate (isethionate).  Does not accept acetaldehyde as a substrate.
What are the official names of this protein?
Sulfoacetaldehyde reductase.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.
Protein: EIPR1_PONAB
Sequence: MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQVGEIWHISASPADRGVLATCYNRTFCCVLSLDSFGALGKSSAQLFIALATSSDSKVLTCAAVWRMPKELESGSHESPDDSSSTAQTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVINRVPRALKYHILL
What is the function of this protein?
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (By similarity).  Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (By similarity).  Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (By similarity).  Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity).  Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity).
What are the official names of this protein?
EARP and GARP complex-interacting protein 1, Endosome-associated recycling protein-interacting protein, Golgi-associated retrograde protein-interacting protein, Tumor-suppressing STF cDNA 1 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EIPR1 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network.
Protein: NU4M_BRAFL
Sequence: MNHLVLGYVGLVIGVIVTKKSMVWRVGQVGSVLLMLPATVLVNMNMTISNVSYMMTSDFVSLGLTVLSIWLLPLMLLASQQHMVSESLIYQRVFVGCQVFLTGALVLAFMASDLLLFYIAFESTLLPTLMLITRWGAQKERYQAGTYFMFFTLVGSLPLLICLIGQYQMVGSLALDLSYEGVFQLSYLVNFWWVGCILAFLVKLPLYGVHLWLPKAHVEAPIAGSMVLAGVLLKLGGYGMMRVSLMWGATAMLSSEVFLALALWGIVVMGGICLRQTDLKSLIAYSSVGHMALVVGGVLTGVAWGYNGAMVLMIAHGLVSSCLFCLANLWYERSSTRNLSGSRGLIMIFPLISSGWFLMSLMNMALPPAINLFGELVAMVALYNWSPYSIVYMSLGAVLTAAYSLYLFGMSQWGNTMKNYKNLYTITSREYLLTTLHLVPAIYLIFYLGLMF
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: MRAY_NEIMF
Sequence: MFLWLAHFSNWLTGLNIFQYTTFRAVMAALTALAFSLMFGPWTIRRLTALKCGQAVRTDGPQTHLVKNGTPTMGGSLILTAITVSTLLWGNWANPYIWILLGVLLATGALGFYDDWRKVVYKDPNGVSAKFKMVWQSSVAIIASLALFYLAANSANNILIVPFFKQIALPLGVVGFLVLSYLTIVGTSNAVNLTDGLDGLATFPVVLVAAGLAIFAYASGHSQFAQYLQLPYVAGANEVVIFCTAMCGACLGFLWFNAYPAQVFMGDVGALALGAALGTVAVIVRQEFVLVIMGGLFVVEAVSVMLQVGWYKKTKKRIFLMAPIHHHYEQKGWKETQVVVRFWIITIVLVLIGLSTLKIR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COX3_CAEEL
Sequence: MFHNFHILSLSSYAYNLFFASAGMLSSLVMFFKFGLYELFIFTLFSVLFISFAWGKDIAMEGLSGYHNFFVMDGFKFGVILFVFSEFMFFFCIFCTFFDAALVPVHELGETWSPFGMHLVNPFGVPLLNTIILLSSGVTVTWAHHSLLSNKSCTNSMILTCLLAAYFTGIQLMEYMEASFSIADGVFGSIFYLSTGFHGIHVLCGGLFLAFNFLRLLKNHFNYNHHLGLEFAILYWHFVDVVWLFLFVFVYWWSY
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y4389_NOSS1
Sequence: MQSFTDTPDFQLTTKNTPSVVMTSDLRKVYRTGFWMNQKVVSLKGCSLTVYQGETFGLLGPNGAGKTTLLKLLLGIIRPSGGKGLLLGQPLGDRHIKQRVGYLSENPYLYEYLTGWEFLELAAGLFEIPASVQRQRIPELLDLVGLSVADAQKKQMRRYSKGMLQRVGMAQALINDPELIFLDEPMSGLDPLGRYRMREIILSLKAAGKTIFFNSHILSEVEKICDRIAILSQGELVCSGSLDELLGSQNTYHVQGQNGDWEILKKWLANLVYEPDGYWQGTLQEDYYDFLASVRLMGGRIISMNLSRQSLEEFFINQIQKQDTSLHEVIDQSEV
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein all4389.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: NDK_PROM3
Sequence: MAVERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQLAPSRELAGEHYGVHRERPFFAGLVDFITSGPVVAMVWEGDGVIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSDGPDTAQFEINLWFSPEELNAWTPSDQSWRVES
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_PSEE4
Sequence: MAELTTLARPYAKAAFEHAQAHQQLANWSAMLGLAAAVSEDGTMQRLLKAPQLTSAEKAAAFIEVCGDKFDAQAQNFIHVAAENDRLLLLPEISALFDLYKAEQEKSVDVEVTSAFALNQEQQDKLAKVLSARLGQEVRLHASEDASLIGGVVIRAGDLVIDGSVRGKIAKLAEALKS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RPO3_METJA
Sequence: MITIKEKRKTRIGEEFIFSLKAPISFSNAIRRIMISEVPTFAIEDVYIYENSSSMDDEILAHRLGLIPIKGKPLLENEVITFTLEKEGPCTVYSSDLKSENGEVAFKNIPIVKLGKGQRIQIECEAIPGIGKVHAKWQPCNAVYKQIADDEVEFFVETFGQMEAEEILEEAVKILKNKAESFLQQLEMIEQ
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo3, DNA-directed RNA polymerase subunit D, mjD.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.