PharMolix/UniProtQA huggingface dataset:
Protein: THIC_MYCUA
Sequence: MTVTVEPSITTGPIAGSSKAYREVAGPDGVTLRVPLRRVHLSTGADFDLYDTSGPYTDPNAVIDLAVGLPARPGLVRDRGTQLQRARAGEITAEMAFIAAREGMSAELVRDEVALGRAVIPANHNHPESEPMVIGKAFAVKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELTWELYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDILARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGVQVMIEGPGHVPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAGDLAKGHPHAQERDNALSQARFEFRWNDQFALSLDPDTAREYHDETLPAEPAKTAHFCSMCGPKFCSMRITRDVRDYAAKHGLDSEEAIEAALEAGMAEKSAEFADHGNRVYLPITQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: ALA6_ARATH
Sequence: MARRRIRSRIRKSHFYTFRCLRPKTLDDQGPHVINGPGYTRIVHCNQPHLHLATKLIRYRSNYVSTTRYNLLTFLPKCLYEQFHRVANFYFLVAAILSVFPLSPFNKWSMIAPLVFVVGLSMGKEALEDWRRFMQDVEVNSRKASVHKGSGDFGRRTWKRIRVGDIVRVEKDEFFPADLLLLSSSYEDGICYVETMNLDGETNLKVKRCLDATLALEKDESFQNFSGTIKCEDPNPNLYTFVGNLECDGQVYPLDPNQILLRDSKLRNTAYVYGVVVFTGHDTKVMQNSTKSPSKRSRIEKRMDYIIYTLFALLLTVSFISSLGFAVMTKLLMAEWWYLRPDKPESLTNPTNPLYAWVVHLITALLLYGYLIPISLYVSIEVVKVLQAHFINQDLQLYDSESGTPAQARTSNLNEELGQVDTILSDKTGTLTCNQMDFLKCSIAGTSYGVRASEVELAAAKQMAMDLEEKGEEVANLSMNKGRTQRYAKLASKTSSDFELETVVTASDEKDQKQNTGVKGFSFEDNRLMNENWLNEPNSDDILMFFRILAVCHTAIPEVDEDTGMCTYEAESPDEVAFLVASREFGFEFTKRTQSSVFIAERFSSSGQPVDREYKILNLLDFTSKRKRMSAIVRDEEGQILLLCKGADSIIFERLSKSGKEYLGATSKHLNVYGEAGLRTLALGYRKLDETEYAAWNSEFHKAKTSVGADRDEMLEKVSDMMEKELILVGATAVEDKLQKGVPQCIDNLAQAGLKIWVLTGDKMETAINIGYACSLLRQGMKQISISLTNVEESSQNSEAAAKESILMQITNASQMIKIEKDPHAAFALIIDGKTLTYALKDDVKYQFLALAVDCASVICCRVSPKQKALVTRLAKEGTGKTTLAIGDGANDVGMIQEADIGVGISGVEGMQAVMASDFSIAQFRFLERLLVVHGHWCYKRIAQMICYFFYKNITFGLTLFYFECFTGFSGQSIYNDSYLLLFNVVLTSLPVISLGVFEQDVPSDVCLQFPALYQQGPKNLFFDWYRILGWMGNGVYASIVIFTLNLGIFHVQSFRSDGQTADMNAMGTAMFTCIIWAVNVQIALTMSHFTWIQHVMIWGSIGAWYVFLALYGMLPVKLSGNIFHMLVEILAPAPIFWLTSLLVIAATTLPYLFHISYQRSVNPLDHHIIQEIKHFRIDVEDERMWKREKSKAREKTKIGFTARVDAKIRQLRGRLQRKHSVLSVMSGTSSNDTPSSNSQ
What is the function of this protein?
Involved in transport of phospholipids and in regulation of pollen plasma membrane lipid asymmetry.
What are the official names of this protein?
Phospholipid-transporting ATPase 6, AtALA6, Aminophospholipid flippase 6.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Protein: ADDB_STRP4
Sequence: MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLECLSQQASFSITVTRFAQMARYLVLNDLPVKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRTDLLLIFEKVTAYLNQGQLAQGSQLSHLIEAIENDKVSSDFNQITLVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLLRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQIFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSARKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDLQGLENPAIPTSPSSKTLAKDTLQALYPAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLRPDARSHGNFLHRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWFEKIREELNR
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: UVRB_MYCPL
Sequence: MEEKFVLHSPFAPSGDQPEAIKALVDGIDEKKEHQVLLGVTGSGKTFTIANVIAQLNRPSLIISHNKTLASQLYSELKALFPDNRVEYFVSYFDFYKPEAYIPKSDLYIEKTSKNNKELEAMRMSAINALSIRKDTIVVASVAAIYGESNPKHYRQNFFPIEVGMQIDRKSLLLKLSQIGYERNRMELNKGQFDVKGDSIEICPGYVSDTNIRIDMFGNEIEAITLIDPLSKNVEGSRKNMTLFPATTYTVHENTIQNTVDLIKQELSERIEYFKSHDKLLEAQRIKDRTLNDLDSLLEFGYTSGIENYSRYLDGRAPGQRPYTLFDYLPDDSVIFIDESHLMIPQLHGMHNGDRARKLSLVEYGFRLPSALDNRPLRFEEFAEFKFPKIYISATPGDYELDLTHGEIVTQYIRPTGLLDPIIEIHSRDNQIEDIYDHLKEQIAKKERTLILTTTKKNAEELSLFLQEKKIKSAYIHDRFKIFERNEILKGLRMGKFDVVVGINLLKEGIDLPEVSLICVLNADSTGLMRDTRSLIQIVGRAARNDHGKVIFYANEITSSMRECIEDNLFKRKIQSEYNEKHNIIPKTIVKPIAPPIQNGILSEDHSKYYGEKDLSQMKHNKKFIDQMVRKMTQLAKANKFEEAIEIRDYLIEIGIELDK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_RICFE
Sequence: MNKYQTHWVEHSEVKILSTTGKKHIALVAGGMSAEREVSLVSSEGVSKALIELGYKVTFIDMGADIAVKLQEIKPDIVFNCLHGTYGEDGCLPGLLNIMRIPYTHSGVLSSALAFDKIHSRSWFLTNNINMAESIIVNKSDNIKSDPVKRPYVIKPLTQGSSIGVEVIFEEDDFNFADYNFPYGYQVIIEQYIKGRELQVAVLNGKALGALEIKLLKNRFYDYETKYTEGFAEHLCPAPLPTNLYEKLLVESEKIYKTMNCKGPARAEFILEEQTNKLYALEINTHPGMTPLSIVPEIAAYAGINFTNLIEEIIKTASFES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y148_CAMJE
Sequence: MGVKAYLDGILGEDKACKFLKKQGFEILKRNFHSKFGEIDIIAKKDEILHFIEVKFTQNDYEVSERLDRKKLEKILKTIEFYHLKNGISSDFQIDLICIKNDVIQFCENISF
What are the official names of this protein?
UPF0102 protein Cj0148c.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RSMH_LEIXX
Sequence: MSDDIHGDIHLPVLLERCIELLAPALQEPGAVIVDATLGMGGHSAGILARFPQATLVGLDRDPDALAIAGERLARFGDRVHLVHTVYDGIREALDGLGIAEVQGVLFDLGVSSLQLDRVERGFSYSKDAPLDMRMDGTSDLTAERVLAEYPEADLRRIFRDYGEEKLAARYAQRIVAARQQGPITRSGELVHLLQRATPAAIARQGHPAKRVFQALRIEVNQELAVLERALPAAVDALAVGGRLVVESYQSLEDRIVKRELQTRSRSSAPAGLPVELPEHRPELRLLIRGAELADDDEKAANPRAAPVRLRAAERTRASEDRRGS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDP60_ARATH
Sequence: MESTNLKNAKHETLVMDPISFQSKAQEVSRFSENSNPNFVSHSTPLEKSSKSSAQKNPKWKPNPVPAVFSPRNRIRERRFVVVKKNSRKEKNDSASVDCKCGAKTISNMKKCVCIAYETLRASQEEFFNNRRESVSEIGESSQNLEDGNEQVEFGDSDETRVSLMKRRREKVLEEARMSIPEFGKVMHLVKAFEKLTCFPLSKVTSKEEEDQIKQPLKWELPGMSQPKCSESETDQFTWSSSFYPSSGLILTATNLGLEQPHASVSSSWDNSVSSLNSNGGRRGRRNSFESSASMGSRRSTKKQIKVTSLKPFKLRTEERGRMKEEEFAKKLHEMTLEKAKKRIPIAQGLPWTTDEPENLVKPHVKDITIPVDLKLHSDIRAVERAEFDYQVTEKINLVEQYKTERERQQKLAEEEEIRRLRKELVPKAQPMPYFDRPFIPKRSNKHPTVPRDPKFNIPQHKKIRCCSTSSWSDTGSYMSDLLYQQDL
What is the function of this protein?
Binds directly to microtubules (PubMed:29167353).  Microtubule-destabilizing protein involved in the PIF3-dependent positive regulation of hypocotyl cell elongation via the modulation of cortical microtubules dynamic in response to light and ethylene signaling (PubMed:29167353, PubMed:31638649).  Promotes submergence-induced and ethylene-dependent underwater hypocotyl elongation (PubMed:31638649).
What are the official names of this protein?
Microtubule-destabilizing protein 60.
What is the protein family that this protein belongs to?
Belongs to the TPX2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Protein: RS211_PARXL
Sequence: MTTILLKENEPFEVAIRRFRRAIEKNGLIAELRERQSYEKPTTARKRKKAAAVKRLHKRLRSQMLPKKLH
What are the official names of this protein?
30S ribosomal protein S21 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: ZFP92_HUMAN
Sequence: MAAILLTTRPKVPVSFEDVSVYFTKTEWKLLDLRQKVLYKRVMLENYSHLVSLGFSFSKPHLISQLERGEGPWVADIPRTWATAGLHIGDRTQSKTSTSTQKHSGRQLPGADPQGGKEGQAARSSVLQRGAQGLGQSSAAGPQGPKGAEKRYLCQQCGKAFSRSSNLIKHRIIHSGEKPYACPECGKLFRRSFALLEHQRIHSGEKPYACPECSKTFTRSSNLIKHQVIHSGERPFACGDCGKLFRRSFALLEHARVHSGERPYACPECGKAFSRSSNLIEHQRTHRGEKPYACGQCAKAFKGVSQLIHHQRSHSGERPFACRECGKAFRGRSGLSQHRRVHSGEKPYECSDCGKAFGRRANLFKHQAVHGARRPAKAETARRLAGPGSTGPGSAVAATSPPRPSTAARPSRPSRR
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 92 homolog, Zfp-92.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVC_SALSV
Sequence: MSIILGIDPGSRITGYGVIRQVGRQLTYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: SPB4_EMENI
Sequence: MAPKPPSGTSSRAWDAVNPPLSEWVLDAVSSMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPIKKHHVGAIIVSPTRELASQIYNVLTSLLAFHPASAAVINTSETEDVPRPKHSSSVLRVVPQLLLGGSTSPAEDLSTFLKRSPNLLVATPGRLLELLSSPHVYCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKVVVKVKGASGVDDKRTPASLQMTYLTQPPTGKFPALKHILNSVQPTPSKSIFFVSTCSGVDYLSVILPLILGNDFQLIPLHGKHPANVRQKNFNRFVNAHNPAILLTTDVASRGLDIPSVDLVVQIDPPSDPKTFIHRCGRAGRAGRRGLSVVLLHPGREEDYVSFLEVRKTPVAPFPHPITVSDAEAAAATETARKVVKADRAIHDRGQKAFVSWLRSYSKHQASSIFRVADLDWEGLGKAWGLLKLPKMPELKNFKGDKTLGVQMDWDTYAYKDKQREKRRLELLQEMAESGQQQTTNKKRPNETVAWSNNAENRNKKAKRRDMKQVRQERKRWEKMTEEEKKKALETEQMLEQIRAKNEEQRRLKRAAAKADKDAEEGGDEEFTGFD
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.  Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA.  Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5. 8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
What are the official names of this protein?
ATP-dependent rRNA helicase spb4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ATP8_ARBLI
Sequence: MPQLEFTWWIINFFIVWTADFTLLIVLSIPNLSTPTTLSKQLDINKSHVTWQWS
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: ERG12_BRANA
Sequence: MDMAFVEVCLRMLLVFVLSWTIFHVNNRKKKKATKLADLATEERKEGGPDVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLMLSKLGLQDCLEEIDAQKSTGIRLFKDGKETVACFPVDTNFPYEPSGRFFHNGRFVQRLRQKASSLPNVRLEEGTVRSLIEEKGVVKGVTYKNSSGEETTSFAPLTVVCDGCHSNLRRSLNDNNAEVTAYEIGYISRNCRLEQPDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSKNLPSVSNGEMTSFVRNSIAPQVPLKLRKTFLKGLDEGSHIKITQAKRIPATLSRKKGVIVLGDAFNMRHPVIASGMMVLLSDILILSRLLKPLGNLGDENKVSEVMKSFYALRKPMSATVNTLGNSFWQVLIASTDEAKEAMRQGCFDYLSSGGFRTSGLMALIGGMNPRPLSLFYHLFVISLSSIGQLLSPFPTPLRVWHSLRLLDLSLKMLVPHLKAEGIGQMLSPTNAAAYRKSYMAATVV
What is the function of this protein?
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
What are the official names of this protein?
Squalene monooxygenase 1,2, Squalene epoxidase 1,2, SE 1,2.
What is the protein family that this protein belongs to?
Belongs to the squalene monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DDL_SALPA
Sequence: MADKIAVLLGGTSAERDVSLNSGAAVLAGLREGGIDAHPVDPQEVDVAQLKAMGFQKVFIALHGRGGEDGTLQGMLELLGLPYTGSGVMASALSMDKLRSKLLWQGAGLPVAPWVALTRAEFEKGLSEEQKARISALGLPLIVKPSREGSSVGMTKVVEENALQGALSLAFQHDDEILIEKWLCGPEFTVAIVGEEILPSIRIQPAGTFYDYEAKYLSDETQYFCPAGLEASQEAALQSLVLQAWKALGCTGWGRIDVMLDSDGQFYLLEANTSPGMTSHSLVPMAARQAGMSFSQLVVRILELAD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_STAA3
Sequence: MATKNEEILRKPDWLKIKLNTNENYTGLKKMMREKNLNTVCEEAKCPNIHECWGARRTATFMILGAVCTRACRFCAVKTGLPNELDLNEPERVAESVELMNLKHVVITAVARDDLRDAGSNVYAETVRKVRERNPFTTIEILPSDMGGDYDALETLMASRPDILNHNIETVRRLTPRVRARATYDRTLEFLRRSKELQPDIPTKSSIMVGLGETIEEIYETMDDLRANDVDILTIGQYLQPSRKHLKVQKYYTPLEFGKLRKVAMDKGFKHCQAGPLVRSSYHADEQVNEAAKEKQRQGEAQLNS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECE_HALLT
Sequence: MDVPYDLNSYIRVLKLASTPSTDEFLQVSKIAGAGILLIGFIGFLMFAIMSLLPGVGA
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE, Protein transport protein Sec61 gamma subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: TFR1_RAT
Sequence: MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAADEEENADSNMKASVRKPKRFNGRLCFATIAVVIFFLIGFMIGYLGYCKRVEQKEECVRLAEAEEADKSENDETEYVPKSSRLFWADLKTLLSEKLNSIEFTDIIKQLSQNTYTPREAGSQKDENLAYYIENLFHDFKFSKVWRDEHYVKIQVKNSVSQNLVTINSGSNIDPVEAPEGYVAFSKAGEVTGKLVHANFGTKKDFEELNYSVNGSLVIVRAGKITFAEKVANAQSFNAIGVLIYMDRNTFPVVEADLQFFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPSIPVQTISRAAAEKLFKNMEGNCPPSWNIDSSCKLELSQNQNVKLTVNNVLKETRILNIFGVIKGYEEPDRYIVVGAQRDAWGPGVAKSSVGTGLLLKLAQVFSDMISKDGFRPSRSIIFASWTAGDYGAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSNFKVSASPLLYTLMGKIMQDVKHPIDGKYLYRDSNWISKIEELSLDNAAFPFLAYSGIPAVSFCFCEDEDYPYLGTKLDTYEILIQKVPQLNQMVRTAAEVAGQFIIKLTHDIELTLDYEMYNSKLLSFMKDLNQFKADIKDMGLSLQWLYSARGDYFRATSRLTTDFHNAEKTNRFVMREINDRIMKVEYHFLSPYVSPRESPFRHIFWGSGSHTLSALVENLRLRQKNITAFNETLFRNQLALATWTIQGVANALSGDIWNIDNEF
What is the function of this protein?
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity).  Endosomal acidification leads to iron release.  The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.  Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).  Positively regulates T and B cell proliferation through iron uptake (By similarity).  Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity).  When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity).  When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
What are the official names of this protein?
Transferrin receptor protein 1, TR, TfR, TfR1, Trfr.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Melanosome.
Protein: DMC1_SCHPO
Sequence: MEEFAEGNDDEQMIFSDIEDLTAHGIGMTDIIKLKQAGVCTVQGVHMSTKRFLLKIKGFSEAKVDKLKEAASKMCPANFSTAMEISQNRKKVWSISTGSEALNGILGGGIQSMSITEVFGEFRCGKTQMSHTLCVTAQLPRDMGGAEGKVAFIDTEGTFRPDRIKAIAERFGVDADQAMENIIVSRAYNSEQQMEYITKLGTIFAEDGQYRLLIVDSIMALFRVDYSGRGELSERQQKLNIMLARLNHISEEFNVAVFVTNQVQADPGAAMMFASNDRKPVGGHVMAHASATRLLLRKGRGEERVAKLNDSPDMPEAECSYVITPGGIADVS
What is the function of this protein?
Required for meiotic recombination and cell cycle progression.  Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity.  Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical and stacked ring nucleoprotein filaments.
What are the official names of this protein?
Meiotic recombination protein dmc1.
What is the protein family that this protein belongs to?
Belongs to the RecA family. DMC1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AC4CH_SHEB2
Sequence: MLLSKITFFERFEHDILSGTKTITLRDEAESHVITGQILPVSTFETDRWFCDIQIIDVTPVKLTELTEVHAKQENMTLPQLCDVIAEIYPGLEQLFMIRFRILSQ
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: RBSD1_RUBXD
Sequence: MKRGGIVNAQLAGALARLGHTDTLVVCDAGLPIPHGPEVVDLAFRLGIPGFGPVLEGILEELVVEEAVAAREVEGANPDCHALLASRLPELKLVPHWELKLRAADARLVVRTGEATPYSNVILRCGVPF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase 1.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXS_CLOB8
Sequence: MEKIASFTINHLELLPGVYVSRQDKFGDTVLTTFDIRMNRPNFEPTMNTAEMHAIEHLAATFLRNHKDYADKTVYFGPMGCRTGFYLILHGDYKSKDIVPLLTELYKFMAEFEGDIPGASAKDCGNYLDMNLPMAKYLANKFLNDILLNITEKNLVYPN
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: HLDD_YERPE
Sequence: MIIVTGGAGFIGSNIVKALNNIGYKDILVVDNLKDGTKFVNLVDLDIADYMDKEDFVASIVAGDDMGDIDAIFHEGACSSTTEWDGKYMMDNNYQYSKDILHFCLDRSIPFLYASSAATYGGRTDNFIEDRQYEQPLNVYGYSKFLFDQYVREILPQADSQICGFRYFNVYGPREGHKGSMASVAFHLNNQINAGERPKLFAGSENFKRDFIYVGDVADVNLWFWQNGVSGIFNCGTGRAESFQAVADAVVDYHQSGPVEYIEFPEKLKGRYQAYTQADLTKLRAAGYGKPFKTVAEGVKEYLAWLNRSV
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.