PharMolix/UniProtQA huggingface dataset:
Protein: CLD18_HUMAN
Sequence: MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
What is the function of this protein?
Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification.
What are the official names of this protein?
Claudin-18.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in epithelial cells.
Protein: MEG4_MAIZE
Sequence: MEYRKRVDALVFFSLLLLGYFAAHAHGKAKEGIMQGNGARCVVGFPPCKDNKCYCCIGGRTHARYSTMAECSHACF
What are the official names of this protein?
Protein MATERNALLY EXPRESSED GENE 4.
What is the protein family that this protein belongs to?
Belongs to the MEG family.
Protein: MAST_VESTR
Sequence: INLKAIAAFAKKLL
What is the function of this protein?
Chemotactic peptide for polymorphonucleated leukocytes (PMNL), but causing no hemolysis to erythrocytes and no mast cell degranulation activity at physiological concentrations.  Potent antimicrobial peptide against Gram-positive and Gram-negative bacteria (By similarity).
What are the official names of this protein?
Mastoparan-T.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Mastoparan subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UREE_STRVE
Sequence: MIFTKVDALVKDIDVDKYHIETVILSSDDLNKKIIRVKSDHGNEFGIRLDKGQKLQNGSAFFIDDHHVLVIGVESQDLIVISPKDMDEMGITAHILGNTHKPIEVKDAKIYLEVDPVVEQVLTQKEIAYTIEEVVLDKPLRHVNLTAHEH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG1_PHOPR
Sequence: MSRKTPIERYRNIGICAHVDAGKTTTTERILFYTGLSHKIGEVHDGAATMDWMEQEQERGITITSAATTTFWRGMEAQFPEHRINIIDTPGHVDFTIEVERSLRVLDGAVVVFCGSSGVEPQSETVWRQADKYEVPRMVFVNKMDRVGADFLRVVDQIKTRLGANPVPIQLNIGAEEEFKGVIDLIKMKAINWSSEDQGMTFTYEDVPADMQDLAEEWRMNLVESAAEANDELMEKYLEEGELSEEEIKAGLRQRTLNNEIVLATCGSAFKNQGVQAVLDAVIDFLPSPTEVKAITGEDELGNAIERHSDDDEPFSALAFKIATDPFVGTLTFMRVYSGVVKSGDTVYNSVKEKRERLGRIVQMHANKREEVKEVRSGDIAAAIGLKSVTTGDTLCDLNNKIILERMEFPVPVIQIAVEPRSQADQDKMGIALGKLAAEDPSFRVETDNESGQTLISGMGELHLDIIVDRMKREFSVDCNVGNPQVAYRETIRGTTKSEGKFIRQSGGRGQFGHVWLKIEPSEPDEGFVFVNEIVGGSVPKEFIGAVAKGVEEQMNSGVLAGFPVLDVKATLFDGSYHDVDSSEIAFQIAGSMAFRDGALNANPVILEPMMKVEVTTPEDWMGDVVGDLNRRRGMIEGMDDGPANLKILRAQVPLSEMFGYATDLRSATQGRASYSMEFSEYAEVPKNVANRIIAERT
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 1, EF-G 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT56_CONVE
Sequence: MLCLPVFIILLLLASPAAPNPLEKRIQSDLIRAALEDADMKTGEREILNIIDSISDVAKQICCQITVDCCVLDEE
What are the official names of this protein?
Conotoxin Vn5.6, Conotoxin VnMLCL-022.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PRO_HTL1L
Sequence: MGQIFPRSANPIPRPPRGLATHHWLNFLQAAYRLEPGPSSYDFHQLKTVLKMALETPVWMCPINYSLLASLLPKGYPGQVNEILQVLIQTQTQIPSHPAPPPPSSPTHDPPDSDPQIPPPYVEPTAPQVLPVMHPHGVPPTHRPWQMKDLQAIKQEVSQAAPGSPQFMQTIRLAVQQFDPTAKDLQDLLQYLCSSLVASLHHQQLDSLISEAETRGITGYNPLAGPLRVQANNPQQQGLRREYQQLWLTAFAALPGSAKDPSWASILQGLEEPYHTFVERLNVALDNGLPEGTPKDPILRSLAYSNANKECQKLLQARGHTNSPLGDMLRACQAWTPRDKTKVLVVQPKKPPPNQPCFRCGKAGHWSRDCAQPRPPPGPCPLCQDPTHWKRDCPRLKPAIPEPEPEEDALLLDLPADIPHPKNLHRGGGLTSPPTLRQVHPNKDPASILPVIPLDPARRPLIKAQVDTQTSHPRTIEALLDTGADMTVLPIALFSSDTPLKDTSVLGAGGQTQDHFKLTSLPVLIRLPFRTTPIVLTSCLVDTKNNWAIIGRDALQQCQGVLYLPEAKRPPVILPIQAPAVLGLEHLPRPPEISQFPLNQNASRPCNTWSGRPWRQAISNRTPGQEITQYSQLKRPMEPGDSSTTCGPLIL
What is the function of this protein?
The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane.  Cleavages take place as an ordered, step-wise cascade to yield mature proteins.  This process is called maturation.  Displays maximal activity during the budding process just prior to particle release from the cell (Potential).  Cleaves the translation initiation factor eIF4G leading to the inhibition of host cap-dependent translation (By similarity).
What are the official names of this protein?
Gag-Pro polyprotein, Pr76Gag-Pro.
What are the subcellular locations of this protein?
[Matrix protein p19]: Virion. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p15-pro]: Virion.
Protein: GLMM_LACLS
Sequence: MGKYFGTDGVRGEANVELTPEMAFKLGRFGGYVLSQHELETPKVYVGRDTRISGQMLASSLISGLLSVGIEVYDLGVIATPGVAYLVKKDGASAGVMISASHNPALDNGIKFFGGDGYKLEDEKELEIEALIDAKEDTLPRPSAQGLGMLHDYIEGVRKYQAFLKTTAEGDFEGYNVVLDTANGASYTSARAVFADLKANLTVIGENPDGLNINVKVGSTHPEAMAKKVVETGSDLGLAFDGDADRLIAVDENGEIVDGDKIMFIVGKYLLEQGKLAQDTLVTTVMSNLGFHLALEEAGINSVITAVGDRYVVEEMKKNNYNFGGEQSGHMIFLDYNTTGDGQLSAIQLLKVMRETGKTLSELASEVTIYPQKLVNVRVKDNAAKKSAMDVPAIQKVISEMETSMNGKGRILVRPSGTEPLLRVMAEAPTHEQVEHVVDTIVEVVEAEIGVK
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ACEA_CYBJA
Sequence: MPYTPIDIKAEQEAFEREVAAVEQWWKEPRWRKTTRIYTAKDIVQKRGTLQIHYPSSDQAKKLYKLLEEHDRNKTASFTFGALDPIHVTQMAKYLDTVYISGWQSSSTASTSNEPSPDLADYPYDTVPNKCEHLWFAQLFHDRKQHEERFRMTPEERAKTPYTDFLRPIIADADTGHGGITAIIKLTKLFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPIQEHINRLVAIRTAADIFGSDLLCVARTDSEAATLLTSTIDHRDHYFIIGSTNKDLQPLSEVMFQAEQRGLLKVMLAAVEEDWTKKAGLKLFHEAVIDEINSGYYPNKQALIAEFTTKVHPLSNTSNKEARALAKKLTGKDIFFDWEAPRVREGYYRYQGGTQCAVNRARAYAPYADIIWMESKLPDYAQAKEFADGVKAQWPEQWLSYNLSPSFNWNKAMSVLYQETYIQKLAKLGYVWQFITLAGLHTTALAVDNFARDYAKIGMRAYGQQIQAPEIENGVEVVKHQKWSGAEYIDNLLKLVTGGVTSTAAMGKGVTEDQFKDDKSKL
What is the function of this protein?
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle.  Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available.  Acts also on 2-methylisocitrate.
What are the official names of this protein?
Isocitrate lyase, ICL, Isocitrase, Isocitratase, Methylisocitrate lyase, MICA, Threo-D(S)-isocitrate glyoxylate-lyase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
What are the subcellular locations of this protein?
Glyoxysome.
Protein: PIM2_MOUSE
Sequence: MARATNLNAAPSAGASGPPDSLPSTLAPPSPGSPAALPRASTPCGLSGFSGLNIRSTSSMLTKPLQGHPSPPVTPTQPPGGKDRAAFEAEYRLGPLLGKGGFGTVFAGHRVTDRRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLWKVGEGNGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKGPLGESCSRSFFTQVVAAVQHCHARGVVHRDIKDENILIDLCRGSIKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPCSRPSLEEILLDPWMQSPAEEKPINSSKGSPTPLPWSLLP
What is the function of this protein?
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.  Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD.  Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity.  The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis.  Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway.  Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1.  Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT.  Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B.  Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
What are the official names of this protein?
Serine/threonine-protein kinase pim-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Protein: ISPH_CITK8
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVLSLDVKNEGKLSFMTQTTLSVDDTSDVIDALRQRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKAAFLIDDATDIQEAWVKEAKCVGVTAGASAPDILVQNVIARLQELGGGEAIPLEGREENIVFEVPKELRVDVREVE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: CC125_MOUSE
Sequence: MSKVPRSSSEAEDIWETEDDMTEGDLGYGLGRKPGGIYEVPCSITSKKRSDGKNSSPPPFPRKGEERSETSFQYSRRKGFQDTSAEGYRASRLSSTDSNSELSDEQLRRRLHEALEDVEILKTELEASQRQLEGKEEALKILQSMAMLGKATSHTQTMLQKTIEQKRSLEKEINALQWEMEFDQDRFKNIEESWIQKCDRLNCDNAVLRENLKLRTEEIKMLKSKNAVLNQRYLEALAMLDIKEQKMGQEESGFTDVSGLELAVLGACLCHGPGGSPCSCAKMAASTRKLVLQLRHELETLQKSKEEAHITADAFRIAFEQQLMRKNEQALRLAGGDLCKRAATWINRQHQADDGYPAQRRKKTLGQRLLGILPSENSSKGAEDQDNMQEVFKMLVDLLNDKEEALAHQRKVSYMLARALEDKDTASERNKEKIPMSQTFPFKTAWHDASELCGLRDPVQSNHVSEPMACICSIQHPPKVSDCPRTLKRSCSLPSTLFYK
What is the function of this protein?
May be involved in the regulation of cell migration.
What are the official names of this protein?
Coiled-coil domain-containing protein 125.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_BACC2
Sequence: MHILVVSVNYRTAPVEFREKLTFQAAELERAMTTLQNQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLEIEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQIKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGELTDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEVMAEKYMGHAKSLSELQCALLEADILISSTGASEYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDIDDLQGVVEANRAERLKEAEKIQFMIEEEIVLFKTWLSTLGVVPLISALRDKALAIQSETMVSLERKIPNLSDREKKVISKHTKSIINQLLKDPILVAKEIAAEEGASEKLALFAKIFDLETEEVESRAEEVEHKRVWTPSVPSL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: FABZ_PSEPW
Sequence: MMDINEIREYLPHRYPFLLVDRVTDLDFEAQSIRAYKNVSINEPFFNGHFPEHPVMPGVLIIEAMAQAAGILGFKMLDAKPADGTLYYFVGSDKLRFRQPVLPGDQLVLEAKFIGRKKTIWKFECRALVDGKPVCSAEITCAEREL
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP4E1_MOUSE
Sequence: MSDMVERTLTALPGLFLQNQLGGPAASRAPFFSRLGGLIRGVTALSSKHEEEKLIQQELSSLKATVSAPTTTLKTMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFYLIAPNQVQHIHTKFRKALCDRDVGVMAASLHIYLRMIKENASGYKDLTESFVTILKQVVGGKLPVEFSYHSVPAPWLQIQLLRILGLLGKDDERTSELMYDVLDESLRRAELNHNVTYAILFECVHTIYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPSLALQHQITIIECLDHPDPIIKRETLELLYRITNAQNVVVIVQKMLEYLHQSKEEHIIISLVGRIAELAEKYAPDNVWFIQTMNAVFSVGGDVMHPDILSNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENTFYPQRFLQVMSWVLGEYSYLLDKESPEEVITRLYKLLMSDSISSETKAWLFAAVTKLTPQAHSSPLVEKLIQEFTVSLNTCLRQHAFELKHLHENTELMKSLLQGAQNCEDIVADASLSFLDGFVAEGLSQGAAPYKPHHQRQEEQLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDISGNSAETGLKETSSLKMEGIKKLWGKEGYLPKKESGTGDKPEASHVPAEGATVENVDQATTRKDQAQGHIPSTEEKEKQLLASSLFVGLGPENTVDLLGKADVVSHKFRRKSKLKVAQSDKTPSAPTAPCSALSLGSDVAGGDEDGLSAVDRGDGELSSELFRSESLSGPPSAEKLESVSLPVPSLFADNNMEVFNPPSSSATSTVKEETPECRHSGLVEICSNEAVSVSSYKVWRDDCLLVIWAVTSKTDSEFTDAQLEIFPVENFKIIEQPECSSPVIETERTKSFQYSVQMESPCIEGTLSGFIKYQMMDTHSVQLEFSMNLPLLDFIRPLKISTEDFGKLWLSFANDVKQTIKISEPGVALTSVLTELQQNLRLRVIDVIGNEGLLACKLLPSTPCVLHCRVHADAVALWFRSSSSVLSDYLSCHCQKVMQTS
What is the function of this protein?
Component of the adaptor protein complex 4 (AP-4).  Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection.  They control the vesicular transport of proteins in different trafficking pathways.  AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.  It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons.  AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.
What are the official names of this protein?
AP-4 complex subunit epsilon-1, AP-4 adaptor complex subunit epsilon, Adaptor-related protein complex 4 subunit epsilon-1, Epsilon subunit of AP-4, Epsilon-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Protein: GRA6_GIBZE
Sequence: MSNIAHGNPQKRPGYAIDIEASCRKRGKSAPAEDCLNEAKTPLDEIESRVVALQRQIANLNSGTLLQSIKEATARLATSWALVTKHQRYVDGYQELALPDAPTYHVQALKTAQSDLEKASQDAQAADGVLASAQKEQRDFKRVEENLVMLGAERATLDQSVRDLTLDKERCDVYLGMVEYGPDGLATLLEKDVGAWKGMLDLV
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461).  The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable).  The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable).  The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable).  Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable).  On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable).  Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable).  The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable).  The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable).  The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
What are the official names of this protein?
Gramillins biosynthetic cluster protein FGSG_00038.
Protein: KPYK_STAEQ
Sequence: MRKTKIVCTIGPASESEEMLEKLMNAGMNVARLNFSHGSHEEHKARIDTIRKVAKRLNKTIGLLLDTKGPEIRTHNMKDGLIVLEKGKEVIVSMNEVEGTPEKFSVTYENLINDVNIGSYILLDDGLVELQVKEINKDKGEVKCDILNTGELKNKKGVNLPGVKVNLPGITDKDADDIRFGIKENVDFIAASFVRRPSDVLDIRQILEEEKAEITIFPKIENQEGIDNIEEILEVSDGLMVARGDMGVEIPPESVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGQYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGVSVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEKTARQCAIVWGVNPVVKEGRKTTDALLNNAVATAVETGRVSNGDLIIITAGVPTGEKGTTNMMKIHLVGDEIAKGQGVGRGSVVGHAIVADSASDLEGKDLSDKVIITNSVDETLVPYVEKAIGLITEENGITSPSAIIGLEKGIPTVVGVEQATKEIKNDMLVTLDASQGKVFEGYANVL
What are the official names of this protein?
Pyruvate kinase, PK.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PEP-utilizing enzyme family.
Protein: PSBK_CYACA
Sequence: MIINQLPETYNIFAPIIDIMPVIPILFLLLAFVWQAAVGFR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: P2C16_ARATH
Sequence: MEEMTPAVAMTLSLAANTMCESSPVEITQLKNVTDAADLLSDSENQSFCNGGTECTMEDVSELEEVGEQDLLKTLSDTRSGSSNVFDEDDVLSVVEDNSAVISEGLLVVDAGSELSLSNTAMEIDNGRVLATAIIVGESSIEQVPTAEVLIAGVNQDTNTSEVVIRLPDENSNHLVKGRSVYELDCIPLWGTVSIQGNRSEMEDAFAVSPHFLKLPIKMLMGDHEGMSPSLTHLTGHFFGVYDGHGGHKVADYCRDRLHFALAEEIERIKDELCKRNTGEGRQVQWDKVFTSCFLTVDGEIEGKIGRAVVGSSDKVLEAVASETVGSTAVVALVCSSHIVVSNCGDSRAVLFRGKEAMPLSVDHKPDREDEYARIENAGGKVIQWQGARVFGVLAMSRSIGDRYLKPYVIPEPEVTFMPRSREDECLILASDGLWDVMNNQEVCEIARRRILMWHKKNGAPPLAERGKGIDPACQAAADYLSMLALQKGSKDNISIIVIDLKAQRKFKTRT
What is the function of this protein?
Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth.  Confers enhanced sensitivity to drought.
What are the official names of this protein?
Protein phosphatase 2C 16, AtPP2C16, AtP2C-HA, Protein HYPERSENSITIVE TO ABA 1, Protein phosphatase 2C HAB1, PP2C HAB1.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly cytoplasmic.
Protein: H4_DENKL
Sequence: MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PHX2B_HUMAN
Sequence: MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQRPNGAKAALVKSSMF
What is the function of this protein?
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus.  Transcription factor which could determine a neurotransmitter phenotype in vertebrates.  Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
What are the official names of this protein?
Paired mesoderm homeobox protein 2B, Neuroblastoma Phox, NBPhox, PHOX2B homeodomain protein, Paired-like homeobox 2B.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KDSB_POLNS
Sequence: MNADSKAPDFLVVIPARLGSTRLPRKPLADIGGKPMVIRVAERAKQSLAHSVVVATDSPEIQAACDEHRIECLLTSENHPTGTDRIAEVAQLLKLPANALVVNVQGDEPLIPPKLINQVARTLAEHEQCVISTVAVPITDAAEINNPNVVKVVLNRSGEALYFSRAPIPFVRDPQSSQKTMHLRHLGIYAYRADFLQAYTRLEPASPEQAEALEQLRALWNGYRIAVHTAPEAPPAGVDTPEDLERVRQLLARS
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.