PharMolix/UniProtQA huggingface dataset:
Protein: PGCA_STAEQ
Sequence: MKNNWIDVLDESLVKDFYNNQTSEEQQEGLNTTLSFGTAGIRGKFGLGEGRLNKFTVSKVALGFAHYLTSSIAHPVVVIHYDTRHLSPEFAQIIANILASHDIKVYLADTYRTTPDLSFAVRYLQADAGVMITASHNPKDYNGIKVYGEDGAQLSTDASAQLSTYIDKLGHPLHINVPSLTTEQQSLIHSVPSEVREDYFKNVQDLVGTIPQSDLKVVFTSLHGTSVPIVPDILSSLNFNQFELVASQCEPDSDFSSVASANPEDHKAFDQSIELANLIDADLLIGTDPDADRLGIVERDAEGNIYYYNGNQIGALLLNYRIKQTEGLPNRIMFQSIVSGGLAKSLAQYHNVNFKEVLTGFKYIAAEIRHLSPEQNFIFGYEESYGFLARPFVRDKDAIQIVPLMIKYAAELKNEGRMLKDELEDITRNVGNFNDKLFSHTFEGTQGKAKIENIMTQFRSETPTEMCGLKVIAIEDFETGKKTDLQNDEVSDITLPKANVIKIYFNEGFIALRPSGTEPKIKLYVSLSCDHFDVIAQKINDAIFNS
What is the function of this protein?
Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate.  This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i. e.  a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).
What are the official names of this protein?
Phosphoglucomutase, PGM, Alpha-phosphoglucomutase, Glucose phosphomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: TOLB_BRUMB
Sequence: MKIGIINTKIRTVFSAFACMIAASLVCTMPARAVVEININKGVIEPLPIAITDFLSADQLGSNITSVIAADLERSGLFAPIDKGAFIEKISNPDAAPRFEDWKVINAQALVTGRITKQPDGRLKAEFRLWDTFGGQQMIGQQFFTTPDNWRRVAHIIADAIYERLTGDKGYFDTRVVFVDESGPAQKRVKRLAIMDQDGANVRFISDGRALSLTPRFSPNRQEVTYMSFEGGSPKVYLLQLETGQRELVGNFPGMTIAPRFSPDGQKVVMSLLQDDGSANIYTMDLRNRTTTRLTSSQAIDTGASYSPDGSQIVFTSDRGGRPQLYVMGADGSNPRRISMGDGSYSTPVWSPRGDLIAFTKQSQGQFSIGVMKTDGSGERLLTSGFHNEGPTWAPNGRVLMFFRKAAGAGGPKLFTIDLTGRNERQIQTPNFASDPAWSPLLE
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TRPF_SULAC
Sequence: MVKVKFCGIASLEDAILAEKLGADFIGFVTDTASPRFVKKDFIGFVRRYVEIPTVEVIVKGNVSESIDKTKADLIQIHRVLTRRELDEIHMYRKKVILYVPSSDMYQEYFRSVISMGFNVLVDSEIKGSKVNLDLARGWAKEYEIGIGGGISPDNLHDFLSINPKWIDVSSGIEKYKGKKDPSKMLKIIEGVRKWKYTQ
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RS16_UREPA
Sequence: MKILVKIRLTRVGTHKKPFFRIVVMDAKTKANGAYIENLGHYDPVLGQVVLKKEAILAQLQNGAQPSETVKNILSQEGIWKEFIALKDANKKRKAALSKAK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SMG_SHISS
Sequence: MFDVLMYLFETYIHTEAELRVDQDKLEQDLTDAGFEREDIYNALLWLEKLADYQEGLAEPMQLASDPLSMRIYTPEECERLDASCRGFLLFLEQIQVLNLETREMVIERVLALDNAEFELDDLKWVILMVLFNIPGCENAYQQMEELLFEVNEGMLH
What are the official names of this protein?
Protein Smg.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: MALC_MALAU
Sequence: MAPTRRSRDLLRGKNVLIIGGTSGIGFAVAQLVIEHGAMACIAGSNPTKLGKALDALKQHPDRDPIAIVQSATCDLFDVPNLEQNLDNLLKLAAGDSKIHHIVFTAADMVQPPPLASVTIEQIQRVGTIRFTAPMLVAKLLPKYMELCPENSYTLTSGSHAKQPDPGWSLVTGYCGGVEGLMRGLAVDMMPLRVNVVSPGAVLTPVLRDILGDSLEIALDAARKKSTTGRIARPEDVAEAYLYIMKDQNITGTVLETSAGMLLR
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of malbrancheamide, a dichlorinated fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2. 2. 2]diazaoctane core (PubMed:23213353, PubMed:28777910, PubMed:31548667).  The first step of malbrancheamide biosynthesis involves coupling of L-proline and L-tryptophan by malG, a bimodular NRPS, to produce L-Pro-L-Trp aldehyde through reductive offloading (PubMed:23213353, PubMed:31548667).  This compound undergoes spontaneous cyclization and dehydration to give a dienamine which is reverse prenylated at C-2 by malE (PubMed:31548667).  The other prenyltransferase present in the cluster, malB, displays modest activity, suggesting that may be a redundant gene in the pathway (PubMed:31548667).  Subsequently, a [4+2] Diels-Alder cyclo-addition catalyzed by the bifunctional enzyme malC forms the characteristic bicyclo[2. 2. 2]diazaoctane ring of premalbrancheamid (PubMed:31548667).  The first reaction catalyzed is a NADPH-dependent reduction reaction in which the nicotinamide cofactor is a stoichiometric reagent (PubMed:31548667).  Either NADH or NADPH is effective as a cofactor (PubMed:31548667).  Finally, the flavin-dependent halogenase malA catalyzes the iterative dichlorination of the indole ring of premalbrancheamide to yield C-9 monochlorinated malbrancheamide B, C-8 monochlorinated isomalbrancheamide B, and dichlorinated malbrancheamide (PubMed:28777910, PubMed:31548667).  MalA is also able to brominate premalbrancheamide at C-9 to yield malbrancheamide C, and, to a lesser extend, at C-8 to yield isomalbrancheamide C (PubMed:28777910).  Finally, malA can brominate C-9 monochlorinated malbrancheamide B at C-8 to yield malbrancheamide D, or C-8 monochlorinated isomalbrancheamide B at C-9 to produce isomalbrancheamide D (PubMed:28777910).
What are the official names of this protein?
Short-chain dehydrogenase/reductase malC, Malbrancheamide biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GPMA_CROS8
Sequence: MAVTKLVLVRHGESQWNNENRFTGWYDVDLSEKGVSEAKAAGKLLKDEGYSFDFAYTSVLKRAIHTLWNILDGLDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPALTKDDERYPGHDPRYAKLSEQELPLTESLALTIDRVIPYWNETILPRLKSGERVIIAAHGNSLRALVKYLDNMSEEEILELNIPTGVPLVYEFDENFKPIKHYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: GLND_PHOLL
Sequence: MSADIATIQAPIPPLSPADFSSEDLRYPVLKQHLEEFQLWLEHAFKAGISAEALISARSDYIDQLLQQLWYAYRFDKISSLSLIAVGGYGRRELHPLSDIDVLILSEQPLTPPQAQNVGQFITLLWDIRLEVGHSVRTLEECLLEGLSDLTIATNLIESRLICGDSSIFLRLQRHTFSDGFWPSTEFFDAKIVEQHERHQRYHSTSYNLEPDIKSSPGGLRDIHTLLWVARRHFGATSIDEMVDFGFLTAEERNELNECQSFLWRIRFALHLVVNRYDNRLLFDRQFSIAQLLGYHGERNQPVERMMKDFYRMTRRVSELNNMLLQLFDEAILALETNEKSRSLDSEFQLRGQLIDLIDETLFIKEPAAIMRMFYRMAEHEEVQGIYSTTLRHLRYARRNLSQPLCELPEARQIFMDILRHPRAVESAFVPMHRHSVLGAYTPLWGNIVGQMQFDLFHAYTVDEHTIRVLRKLESFANENNRPAHPLCVELYPRLPQPELLHLAALFHDIAKGRTGDHSELGADDALAFSLKHGLNSREADLVAWLVRHHLLMSVTAQRRDIQDPEIIKQFTHQILNETRLRYLICLTVADICATNVNLWNSWKQSLLRELYFSTENQLRQGNTPDFRERIRHNRFQALALLRQDNINEQKLHQLWSRCHADYFLRHTPKQLAWHAHHLVQHDSQESLILISTKPTRGGTEIFIWSVDRPSLFAAVVGELDRRNLSVHHAQIFTNRDGMTMDTFVVLEPNGHPLASDRHEIIRNALLQVVLAPHTKTPKTRKLPTKLRHFNVPTKVTFLPTHNERRTYMELFALDQPGLLARVGNIFAEMGVSLHGAHITTIGERVEDFFVLADKDHKALNKKVREELSERLTATLNPKDKI
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: 2ABB_XENLA
Sequence: MPCSVEDKTGLCGSRYSVMIPELQESVIFSEDSRHYNEKQTRRQRKSSADIISTVEFNNTGELLATGDKGGRVVIFQREQENKNQPHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRIRDPCTITSLRVPVLRPMDLMVEATPRRVFSNAHTYHINSISVNSDYETYMSADDLRINLWNLEITNRSFNIVDIKPTNMEELTEVITAAEFHPHNCNTFVYSSSKGTIRLCDMRSSALCDKHSKLFEEPEDPSNRSFFSEIISSISDVKFNHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN
What is the function of this protein?
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).  Negatively control the initiation of oocyte maturation.
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform, PP2A subunit B isoform B55-beta, PP2A subunit B isoform PR55-beta, PP2A subunit B isoform R2-beta, PP2A subunit B isoform beta.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Membrane.
Protein: FLID_ECOLI
Sequence: MASISSLGVGSGLDLSSILDSLTAAQKATLTPISNQQSSFTAKLSAYGTLKSALTTFQTANTALSKADLFSATSTTSSTTAFSATTAGNAIAGKYTISVTHLAQAQTLTTRTTRDDTKTAIATSDSKLTIQQGGDKDPITIDISAANSSLSGIRDAINNAKAGVSASIINVGNGEYRLSVTSNDTGLDNAMTLSVSGDDALQSFMGYDASASSNGMEVSVAAQNAQLTVNNVAIENSSNTISDALENITLNLNDVTTGNQTLTITQDTSKAQTAIKDWVNAYNSLIDTFSSLTKYTAVDAGADSQSSSNGALLGDSTLRTIQTQLKSMLSNTVSSSSYKTLAQIGITTDPSDGKLELDADKLTAALKKDASGVGALIVGDGKKTGITTTIGSNLTSWLSTTGIIKAATDGVSKTLNKLTKDYNAASDRIDAQVARYKEQFTQLDVLMTSLNSTSSYLTQQFENNSNSK
What is the function of this protein?
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament.  Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
What are the official names of this protein?
Flagellar hook-associated protein 2, HAP2, Filament cap protein, Flagellar cap protein.
What is the protein family that this protein belongs to?
Belongs to the FliD family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: ENO_STRP3
Sequence: MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYLGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYTYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIMPVGAPTFKEGLRWGAEVFHALKKILKERGLVTAVGDEGGFAPKFEGTEDGVETILKAIEAAGYEAGENGIMIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQVDYLEELVNKYPIITIEDGMDENDWDGWKVLTERLGKRVQLVGDDFFVTNTEYLARGIKENAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL34_SALAI
Sequence: MSKRTFQPNNRRRAKTHGFRLRMRTRAGRAIISTRRAKGRTRLAA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RS21_NATTJ
Sequence: MAEIKVGKNETLDSALRRFKKQCSKSGVLSEAKKRKHYEKPSEKRKRKATEKRNSRK
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: CML8_ARATH
Sequence: MEETALTKDQITEFKEAFCLFDKDGDGCITVEELATVIRSLDQNPTEQELHDIITEIDSDSNGTIEFAEFLNLMAKKLQESDAEEELKEAFKVFDKDQNGYISASELSHVMINLGEKLTDEEVEQMIKEADLDGDGQVNYDEFVKMMINID
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Calmodulin-like protein 8, AtCaM-8.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: MUTS2_LISMF
Sequence: MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATDFQVVQKTQLETEEGAKIIRLRGSAPITGLTDVFAHLKRLEIGGDLNGLEIYQIGSNLRVSRQMKNFMNDLLEIGVELPLLGALSDELLVLKEVEEDIAISVDESGKVLDTASEALSTIRRTLRRTEDRVREKLESYLRDRNASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKALQAKEKQEIERILAEISASLAAWINEIHHNTFILGRFDFIFAKARFGKAMKAVTPHLSDAGVVHLIAARHPLLDAAKVVANDIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQIPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIVSILGNVNQKSLILYDELGAGTDPQEGAALAIAILDASHAKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYKLLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEARELARGAGNLLKDLQKEISNYYQQKDKLIEQASEKAATIVEKAEAEAEEIIHELRTMQLNGAAGIKEHELIDAKTRLGNAKPKTINKTIPQAPKQKPHVFQEGDNVRVLSLGQKGTLLNKISDKEWNVQIGIIKMKIKTVDLEYIQPEKPKKQRIITSVHSSGSPAKSELDLRGERYEDALQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVTIVEFK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: THIP_ECOLI
Sequence: MATRRQPLIPGWLIPGVSATTLVVAVALAAFLALWWNAPQDDWVAVWQDSYLWHVVRFSFWQAFLSALLSVIPAIFLARALYRRRFPGRLALLRLCAMTLILPVLVAVFGILSVYGRQGWLATLCQSLGLEWTFSPYGLQGILLAHVFFNLPMASRLLLQALENIPGEQRQLAAQLGMRSWHFFRFVEWPWLRRQIPPVAALIFMLCFASFATVLSLGGGPQATTIELAIYQALSYDYDPARAAMLALLQMVCCLGLVLLSQRLSKAIAPGTTLLQGWRDPDDRLHSRICDTVLIVLALLLLLPPLLAVIVDGVNRQLPEVLAQPVLWQALWTSLRIALAAGVLCVVLTMMLLWSSRELRARQKMLAGQVLEMSGMLILAMPGIVLATGFFLLLNNTIGLPQSADGIVIFTNALMAIPYALKVLENPMRDITARYSMLCQSLGIEGWSRLKVVELRALKRPLAQALAFACVLSIGDFGVVALFGNDDFRTLPFYLYQQIGSYRSQDGAVTALILLLLCFLLFTVIEKLPGRNVKTD
What is the function of this protein?
Part of the ABC transporter complex ThiBPQ involved in thiamine import (PubMed:12175925).  Probably responsible for the translocation of the substrate across the membrane (Probable).
What are the official names of this protein?
Thiamine transport system permease protein ThiP.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDXH_RHOPB
Sequence: MSDATSIKHPSGLTSGDFTAAEEPFALFAEWFAEASGSEPNDPNAMALATVDPDGLPDVRMVLMKGYDSHGFVFYSHIASQKGRELAANPKAALLFHWKSLRRQVRVRGAVTPVSDAEADAYFATRSKQSQIGAWASKQSQPLESRFAFEQAIAGVAAKHLIGAVPRPPGWSGWRVTPARFEFWHDRPFRLHDRIEFRRDTPDHPWTKTRLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: PDXH_SALPA
Sequence: MSDNDQLQQIAHLRREYTKGGLRRRDLPAEPLTLFERWLGQACDARLADPTAMVVATVDDKGQPYQRIVLLKHYDEKGLVFYTNLGSRKAHQIEHNPRISLLFPWHMLERQVMVTGKAERLSTLEVVRYFHSRPRDSQIGAWVSKQSSRISARGILESKFLELKQKFQQGEVPLPSFWGGFRVSIEQMEFWQGGEHRLHDRFLYQRDDGAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RL7_PSEMY
Sequence: MSLTNEQIIEAIGQKSVMEIVELIKAMEETFGVTAAAAVAAGPAAGAAAAVEEQTEFNVVLAEAGDKKVNVIKAVRELTGLGLKEAKEKVDTAPQVIAEGLTKEAAEDAKKKLEEAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: SSRP_METPP
Sequence: MAIADNKKARFNYTIEEQFEAGMVLEGWEVKAIRAGQVQLTDGYVVVKDGELFLIGCRINPLRTASTHVHPQADRTKKLLMKKDEIRRLVGKVEQKGYTLVPLNLHYKGGRVKADIALAKGKDLHDKRETEKKRDWEREKGQLMRHKISSPRKDT
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RPOC_PARL1
Sequence: MNQEVMNLFNPTAPTQTFDQIKISIASPERILSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKYKGIICEKCGVEVTLSKVRRERMGHIELAAPVAHIWFLKSLPSRIGLLLDMTLKDLERVLYFENYIVLEPGLTSLKERQLLTEEEYIDAQDQYGEDSFTAGIGAEAIRELMMALDLEKIAADLRVEIAESTSELKPKKLAKRLKLIEAFIESGNKPEWMIMTQIPVIPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLMELRAPDIIIRNEKRMLQESVDALFDNGRRGRVITGANKRPLKSLADMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYSRLEAKGLSATVKQAKKLVEKERPEVWEILEQVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQLEARVLMMSTNNILHPANGSPIIVPSQDIVLGLYYVTIQKDNEPGEGMVFGSVSEIEHALAVKAVTLHAKVKARYTTKDADGNSYTEVVDTTPGRMMVGELLPRHPNVPFDLVNRLLTKRDISKMIDVVYRHCGQKETVIFCDQIMALGFRQAFRAGISFGKDDMVIPEEKAKLVEETQTLATEYEQQYIDGLITQGEKYNKVVDAWAKCTDRVADVMMQKISAVQIDPETKREKQINSIYMMAHSGARGSPAQMKQLAGMRGLMAKPSGEIIETPIISNFKEGLTVLEYFNSTHGARKGLADTALKTANSGYLTRRLVDVAQDSIITEEDCGTIGGITVQPVIEAGDVIVSLGTRVLGRTTAEDVMNPATGEVLIPKNHLIDEADVDTIEEANVQGIKIRSVLTCEAANGVCGACYGRDLARGTPVNMGEAVGVIAAQSIGEPGTQLTMRTFHIGGTAQVVDSSFIESNHAGTIKIVNRNVVKDSNGVLVVMGRNVQVQIIDEHGGERASHKLTYGSRLKFDDGDKIERGQRISEWDPYTMPMLTEVNGIAEFEDLVDGVSIREVADEATGISSRVVVDWRASPRGSDLRPAVVVKDKNGKILKLANGNDARYLLSVDAILSVDNGAAVHAGDVLARIPTEGAKTRDITGGLPRVAELFEARRPKDHAIIAEATGRVEFGKDYKNKRRIIVHPVDESLEPIEYLIPKGKHISVQEGDVIEKGEFILDGHPAPHDILAISGVEELAAYLVNEVQDVYRLQGVAINDKHIEVIVRNMLQKVEVTSPGESITLPGEQLDRAEFDEMNAKLEAQGKTPATAVPVLLGITKASLQTRSFISAASFQETTRVLTEAAVSGKVDQLVGLKENVIVGRLIPAGTGGMLQRLRGEAQNRDDKILEDQGGATPTASTEIKEPAEGAA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: LON_CHLPN
Sequence: MDSTTNSDSPILDPNPEDVEKLLDESEEESEDQSTERLLPSELFILPLNKRPFFPGMAAPILIESGPYYEVLKVLAKSSQKYIGLVLTKKENADILKVSFNQLHKTGVAARILRIMPIEGGSAQVLLSIEERIRIIEPIKDKYLKARVSYHADNKELTEELKAYSISIVSVIKDLLKLNPLFKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKELDLSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDIEKFSERLRKRHVPDYAMEVIQDEIEKLQTLETSSAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEIVLNKDHYGLDEIKQRILELISVGKLSKGLKGSIICLVGPPGVGKTSIGRSIAKVLHRKFFRFSVGGMRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEVLDPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIAKKYLVPKARKEIGLTASEVNFQPEALKYMINNYAREAGVRTLNGNIKKVLRKVALKIVQNQEKPKSKKITFKISSKNLQTYLGKPIFSSDRFYESTPVGVATGLAWTSLGGATLYIESVQVSSLKTDMHLTGQAGEVMKESSQIAWTYLHSALHRYAPGYTFFPKSQVHIHIPEGATPKDGPSAGITMVTSLLSLLLETPVVNNLGMTGEITLTGRVLGVGGIREKLIAARRSRLNILIFPEDNRRDYEELPAYLKTGLKIHFVSHYDDVLKVAFPKLK
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_BACHK
Sequence: MKQLYGVIGNPIGHSLSPVMHNDAFEHLNMDAHYHAFLVKEEVLGEAVRGLKALGISGFNVTTPHKVAIMDYLDEIDPLAKQIGAVNTVVHKDGKLIGYNTDGIGFVRALQSISSEPLQEKRILLLGAGGASRAIYFSLADAGVKEIDVANRTVDKAKELIAACTATVHSVALSLEKATKEQGSYDIIIQTTTIGMHPRVEHTPLQISSLKKGTIVSDIIYNPFETKILCEAKEQGAIIQNGIDMFVYQGALAFEMWTGCVPNIERMKQLVIRKLGG
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: TM208_DANRE
Sequence: MAPKGKVGTKGKKQIHEENQDTLKFYSRIILGANAIYIAVNLLLFYNSSSFWTWFSLMFAVAVYVGSYRSMSAMAKPAFAEDGSLLDGGIDLNMEQGMAEHLKDVILLTAIVQVLSTLSSYFWYLWLLAPARALHLLWVNFLGPWFSADSQAAPEENEKNDKKQRRQERRQMRRF
What is the function of this protein?
May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
What are the official names of this protein?
Transmembrane protein 208.
What is the protein family that this protein belongs to?
Belongs to the TMEM208 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: OBG_DESAH
Sequence: MRFIDEASITVISGKGGPGCVSFRRERFIERGGPNGGDGGKGGSVIFETDPAKRTLFDLRRQKIIRAKNGMPGLGSNKHGKNGVDLIIPVPPGTLVTDQETGAVLFDLTEPGTRITIAKGGRGGQGNKRFATSTHKAPRFAQPGMPGEEFHLKLELKLLADVGIVGLPNAGKSTLISKISSARPRIADYPFTTLTPSLGMVIPDFGEPFAVADIPGIIEGAHEGTGLGIQFLKHVERTGILIHLIDVSQIEPDNPLDAFNLINTELSLYSATLAKKPQLVVLNKIDLTGSMEKVEQFKKAYGTGELLTLSAATGEGTAKLIQILARQIAEHKPLERKSETDHGNK
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.