PharMolix/UniProtQA huggingface dataset:
Protein: RBFA_STACT
Sequence: MSKMRAERVGEQMKKELMDIINNKVKDPRIGFITITDVQVTNDLSLAKVYLTVLGNEKEVDDTFKALEKAKGFIKSELGSRMRLRIVPELQFEYDHSIEYGNKIEKMIQDLHKKD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAX_I02A0
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKLETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESSDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEVGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKEDYTLDEESRARIKTRLYTIRQEMASRGLWDSFVSPREAKRQLKKDLKSQELCAGLPTKVSHRTSPALKTLEPMWMDSNRTAALRASFLKCPKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: CIA2A_BOVIN
Sequence: MERVSGLLSWTLSRFLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVTESCVEVQEINEDDYLVIIRFTPTVPHCSLATLIGLCLRVKLQRCLPFKHKLEIYISEGTHSTEEDINKQINDKERVAAAMENPNLREIVEQCVLEPD
What is the function of this protein?
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins.  As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation.  May play a role in chromosome segregation through establishment of sister chromatid cohesion.  May induce apoptosis in collaboration with APAF1.
What are the official names of this protein?
Cytosolic iron-sulfur assembly component 2A, MIP18 family protein FAM96A.
What is the protein family that this protein belongs to?
Belongs to the MIP18 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_LEPBP
Sequence: MGIRKLKPTTQSSRYYSVLDFKEITEVVPYKPLTANISYKAGRDNKGRIAVRRKGGRNKRKFRIIDFKRNKFGIPATVKTIEYDPNRSAFIALVCYADGEYRYILAPNGLKVGDKIESGPAAEIKLGNTLPLDKIPAGTNVHNIELHIGKGGQIARTAGSFAVISAKDGDYVSLKLPSSEIRKVRKECLATIGELSNKDHNLVIIGKAGRNRWLGKRPKVRGVVMNPVDHPLGGGEGRTSGGRHPVTPWGKPTKGFKTRKTRPSDRFIVQRRKKNRNR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DNTAB_BURSR
Sequence: MSENWIDAAARDEVPRGRRDRHQYRRQGDCLYEVAGEIYATDNTCTHGAARMSDGFLEGREIECPLHQGRFDVCTGKALCTPLTQDIKTYPVKIENMRVMLKLD
What is the function of this protein?
Component of the 2,4-dinitrotoluene dioxygenase (DNTDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into 2,4-dinitrotoluene (DNT) to form 4-methyl-5-nitrocatechol (MNC) and nitrite.  Functions as an intermediate electron transfer protein via a specific interaction with iron sulfur protein components (ISP)(DntAc and DntAd).  Also able to convert naphthalene to cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene.
What are the official names of this protein?
2,4-dinitrotoluene dioxygenase system, ferredoxin component.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin component family.
Protein: ACP_BRUMB
Sequence: MSDTAERVKKIVVEHLGVDADKVTEGASFIDDLGADSLDTVELVMAFEEEFGVEIPDDAAETILTVGDAVKFIDKASA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_HELPH
Sequence: MKEFDLESYDYYLPKELIANYPVLPKEKAKLLVYERRSQKITHTTFEHVLDFFPKNALVVLNDTKVMKARLFGSKHALLPSKTTEVFFHRFFKDNTALTQIKGKIKAGDKIFFDANYHAEVLELLHNGQRLIAFYNHKTPLNQENILKLLEQYGHMPLPPYIKRTDESLDAHEYQSVFAKHIGAVAAPTASLHFSQNTLEKLLKDFKHAFLTLHVGAGTFLGVETKDIREHQIHTEILHIPKKSQEILRESQEVLCIGTTALRSVEYFKRLKNSNQESFECDIFLHLANPIQHVNYLLTNFHLPKSSLLMLVSAMIGLEKTKEIYKIAIEKKYRFYSYGDGMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1488_LEVBA
Sequence: MADKMQALGAQLTQALQETDEFKALKAAFATMKEDDATYKLFKRFQQIQMDLQQKQMAGQQVTDDEMSRARDVADQVAKIEAVKTLMDAERGVNALLNQLNQTITQPIQDIYAG
What are the official names of this protein?
UPF0342 protein LVIS_1488.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: REN_TYCS1
Sequence: MDLRTGEYITAHQATSGVYTFEITNPLYFTITRHNQQPFNSKYNFLTFQIRFNHNLRKALGIHKCFLNFRIWTTLQSPTGHFLRVFRYQVYKYLNNIGVISLNNVIRAVDYVLFDVFENTIDVIEQHEIKYNLY
What is the function of this protein?
Increases viral DNA accumulation.  Enhances infectivity and symptom expression (By similarity).
What are the official names of this protein?
Replication enhancer protein, REn, Protein C3, Protein L3.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae replication enhancer protein family.
Protein: HB21_BOVIN
Sequence: MSGMVALWIPRGLWTAVVMVTLVMLSTPGAEGRDSPKDFVYQFKGLCYFTNGTERVRYVTRYIYNQEENVRFDSDWDEYRAVTPLGRPDAEYFNSQKDFLEQTRAEADTVCRHNYQVEAPFTWQRQVEPTVTIFLSRTEALNHHNLLVCSVTDFYPGQIKVRWFRNDQEETAGVVATPLIRNGDWTFQLFMMLEMTPQRGDVYTCRVEHPSLQSPIMVEWRAQSESAQSKMLSGIGGFVLGLIFLGLGLIVHHRSQKGLMR
What are the official names of this protein?
BoLa class II histocompatibility antigen, DQB*0101 beta chain, DQB1*1A.
What is the protein family that this protein belongs to?
Belongs to the MHC class II family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RBL_CORFO
Sequence: VGFKAGVKEYKLTYYTPTYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWITVWTDGLTSLDRYKGRCYHIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALYKAQAETGEIKGHYLNATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGEREITLGFVDLLRDDFVEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKEIKFEFEAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PER25_ARATH
Sequence: MGVYLGKYCYIMIIMLVLVLGKEVRSQLLKNGYYSTSCPKAESIVRSTVESHFDSDPTISPGLLRLHFHDCFVQGCDGSVLIKGKSAEQAALPNLGLRGLEVIDDAKARLEAVCPGVVSCADILALAARDSVDLSDGPSWRVPTGRKDGRISLATEASNLPSPLDSVAVQKQKFQDKGLDTHDLVTLLGAHTIGQTDCLFFRYRLYNFTVTGNSDPTISPSFLTQLKTLCPPNGDGSKRVALDIGSPSKFDESFFKNLRDGNAILESDQRLWSDAETNAVVKKYASRLRGLLGFRFDYEFGKAMIKMSSIDVKTDVDGEVRKVCSKVN
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 25, Atperox P25.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS12_FLAPJ
Sequence: MPTIQQLVRIGRTKMTKKSKSVALDSCPQRRGVCTRVYTTTPKKPNSAMRKVARVRLTNGNEVNAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGALDTSGVAGRTQRRSKYGAKRPKEAKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SSRP_ANAMF
Sequence: MEIVAENRKARFDYFVLQEYDAGMVLVGSEVKSLRQRKVNMGDAYVLEKDMELWIHNLHISEYNRSDRKNHKPLRVRKLLLRKREIHKIAGNIKVSGLAVVPLMIFFNNKGIAKIKIAIVKGKKLYDKREAIKTRDWQREKSRISRREV
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: DNAA_THEVB
Sequence: MISSAEDLWHQILERLQLLLSRPTFETWIKTATVQSFDGQTLTICTPNPFARNWLQKYYLKTIADVAREIVGKPVEIELAIAQGAEHDTSIRPTSRGEVEATPPAARHRGSELNPKYVFSRYVVGPNNRMAHAACLAVAESPGREFNPLFLCGGVGLGKTHLMQAIGHYRLEIDPNAKIFYVSTEQFTNDLIAAIRKDSMQSFREHYRAVDVMLVDDIQFIEGKEYTQEEFFHTFNTLHEAGKQVVLASDRPPSQIPRLQERLCSRFSMGLIADIQPPDLETRMAILQKKAEYENIRLPREVIEYIAASYTSNIRELEGALIRAVAYISISGLPMTVENIAPVLSPTVRKIETSPEIILKVVSEALNVPISDLKGNSRRREISMARQVGMYLMRQYTGLSLPKIGEEFGGKDHTTVMYSCDKVAELQRTDPEMGSLLRQLSDRINLASRSTEP
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LFTR_RHILO
Sequence: MTRPYAPGYRIPTDLLLKAYASGVFPMAESASDPEVFWVRPETRGIIPLDGFHTPKSLRKTIRKSLFDIRFDFDFEATIDGCAEKREERRSTWINAPIREAYVQLHRMGHCHSVEAWREDQLVGGLYGVSLGRVFFGESMFSKETDASKICLVHLVERLKARGFALLDTQFTTEHLKRFGAVDVPRGKYEKMLAEALKGEAIFFP
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NLTP_CANSA
Sequence: KCGVSIPYKISPSTDCSSVK
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).
What are the official names of this protein?
Non-specific lipid-transfer protein, LTP.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: COLE_LEPMA
Sequence: MDAYSLSPTDSTTYSSDTFSTEFHTDAIAPPGNTPGNYTLDYNECFFNFCECCPPEKGPMGPMGERGLPGPPGERGPLGLPGEKGETGLRGPPGPAGLPGANGLNGDIGEKGDQGPVGLPGVPGIPGKPGEKGDPGLKGDKGERGFSGLKGDPGERGEPGLNGTKGSIGREGPMGPGLAGTKGLKGEQGLKGECLQGEKGERGPPGLRGEMGLNGTDGVKGERGEPGPLGGKGDTGARGPPGPPGGRGMAGLRGEKGLKGVRGPRGPKGPPGESVEQIRSAFSVGLFPSRSFPPPSLPVKFDKVFYNGEGHWDPTLNKFNVTYPGVYLFSYHITVRNRPVRAALVVNGVRKLRTRDSLYGQDIDQASNLALLHLTDGDQVWLETLRDWNGXYSSSEDDSTFSGFLLYPDTKKPTAMENL
What is the function of this protein?
Forms a microstructural matrix within the otolithic membrane.
What are the official names of this protein?
Inner ear-specific collagen, Saccular collagen.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: EFG_CLOPE
Sequence: MARQYPLEKFRNFGIMAHIDAGKTTTTERILFYTGRNHKIGETHDGASTMDWMAQEQERGITITSAATTCFWKGYELNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAKSGVEPQTETVWRQADKYGVPRMIYVNKMDATGADYYNCINTVRERLQANAVAIQIPIGQEDQFQGMVDLLTNQAIIFKDDLGKDIEVGEVPADLADKAEEYRAAMIEAIAETDEELMMKYLEGEELTLEELKVALRKATINNEIIPVICGSSYKNKGVQQMIDGVVDYLPSPLDIPAVKGTNLDGEEEVREASDDAPMSALAFKIATDPFVGRLAFTRVYSGVLESGSYVLNSTKGKKERIGRLVKMHANSREEVESLEAAELGAVIGLKNTTTGDTLCTEAAPIILEKMEFPEPVISIAIEPKTKAGQEKMGIALSKLAEEDPTFKTWTDQETGQTIIAGMGELHLDIIVDRLQREFKVECNVGAPQVAYKETIKKAVEAEAKFARQSGGRGQYGHCKIEMIPTEGEYEFENAIVGGAIPREYIPAVDNGIREAAESGIIAGYPVINFKIRLFDGSYHDVDSSEMAFKIAGSMAFKNAMAKADAVLLEPIMKVEITVPEEYMGDVIGDVNSRRGRMEGMDSRNGAQIIRAFIPLSEMFGYATALRSRTQGRGTYAMEFDHYDDVPKSIQEEVAGKKNK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDP_STAAC
Sequence: MRMIDIIEKKRDGHTLTTEEINFFIGGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGDMIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPADKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAINSGAALEKFKTFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSNRQDVDDVVKKLDSSITIADHVVSPTLIHKIITE
What is the function of this protein?
Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
What are the official names of this protein?
Pyrimidine-nucleoside phosphorylase, PYNP, Py-NPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: CRCB1_FRACC
Sequence: MNWLLVIAGAAAGAPLRYLTDRAVQTRHDTVFPWGTFTVNVTASLLLGLVAGAAGAGAPPAWVASEQVVSLVGTGLCGALSTYSTFSYETLRLAEDGARLLAAANVAGSVLAAFGAAALGAALARAVWG
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: JIP5_COCIM
Sequence: MFDTVCSLPLSSDLFSQAIHPTEPLVSIGLSSGHVQTFHLPAPSENGKAGYGHIDTVWRTRRHKGSCRCVGFGIDGETLYSAGTDGWVKAARTETGRVEWKFAVPRIGDKSGFQVDSPCLIHALSPQTLLLATDSGALHLFDLRDRSTEVSARPQQTHHPHDDYVSSLTPLPPSETSTSGYSKQWITTGGTTIAVTDLRRGILVRSEDQGEELISSSYVTGLKAGGTSKGEKLVVGGASGVLTLWEKGAWDDQDERIIVDRSLDGGESLEVIANVPDELGKGKVVAVGQSDGRVQFVQLGPNKVISELSHDDLEGVVGLGFDVQGRMISGGGTVVKVWHEAISDEEGNDDESDEEDIENGEGLGKKRKGGNGSSDEEEDSDDDMAGKDKGKRKKRKRGKGKDRSGGVHVMAFKGLD
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TRIM5_MACNE
Sequence: MASGILLNVKEEVTCPICLELLTEPLSLHCGHSFCQACITANHKKSMLYKEGERSCPVCRISYQPENIQPNRHVANIVEKLREVKLSPEEGQKVDHCARHGEKLLLFCQEDSKVICWLCERSQEHRGHHTFLMEEVAQEYHVKLQTALEMLRQKQQEAEKLEADIREEKASWKIQIDHDKTNVLADFEQLREILDREESNELQNLEKEEEDILKSLTKSETKMVQQTQYVRELISDLEHRLQGSMMELLQGVDGIIKRIENMTLKKPKTFHKNQRRVFRAPDLKGMLDMFRELTDVRRCWVDVTLAPNNISHVVIAEDKRQVSSRNPQIMYRTQGTLFQSLTNFIYCTGILGSQSITSGKHYWEVDVSKKSAWILGVCAGFQPDAMYNIEQNENYQPKYGYWVIGLQEGVKYSVFQDGSSHTPFAPFIVPLSVIICPDRVGVFVDYEACTVSFFNITNHGFLIYKFSQCSFSKPVFPYLNPRKCTVPMTLCSPSS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: RS2_MYCGE
Sequence: MSDTNTEKPELVSLNKLSEMRTNIGMVKRYWNPKMGFFIEPERKHNNDLLKLDLQYQALKTAYNFIKDVVKNHGQILFVGTKNDYVKKLVIDIAKRVNVAYITQRWLGGTLTNFKTLSISINKLNKLVEQQKQNANDLTKKENLLLSREIERLEKFFGGVKNLKRLPNLIVIDDPVYEKNAVLEANSLKIPVVALCNTNTNPELVDFIIPANNHQPQSTCLLMNLLADAIAEAKGFETLYAYKPDEQIQIEIPPKQERQVINRSNTRNITNQRLNINRQQQETL
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: ATPD_AROAE
Sequence: MAENVTIARPYADAAFELARGAGALGPWSEALDRLAAAAADASMKACISNPKLSADQLYQLFIDVAGQGFTPELQNFVRVLVDNERLQMLPEIRDLFVELKNEHEGVQEAEIASAFPLDDATLANLKADLETRFKTRLNTKVSLDPELIGGVRIAIGDEVIDASVRGKLANMAAALKN
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NSK2_SARBU
Sequence: XXEEQFDDYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Neosulfakinin-2, Neosulfakinin-II, Neb-SK-II.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SP2AB_ANOFW
Sequence: MRNEMHLQFSALSQNESFARVTVAAFVAQLDPTLDELTEIKTVVSEAVTNAIIHGYENDPSGVVYISVIIEGHTVHLTIRDHGKGIENVEEARQPLFTTKPELERSGMGFTIMENFMDEVNIYSKVNEGTTVELIKHLTKSKALCN
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: RIMP_PSYIN
Sequence: MASLEERLTEMLAPSVEDLGYELVGVEYIRAGKHSTLRVYIDQDEGILVDDCAAVSRQVSAIMDVEDPITNEYSLEVSSPGMNRPLFKAEHYQIFAGEEVKIQLRMPIQNRRRWKGVIVSAEDEIICLNIEGREERFSLSNIQKANIVPKFDN
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_VIBVU
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFIRTKMTKRNNFTAGRVYSDVLAKERRGDYLGATIQVIPHITNDIKDRVINGSQGHDVAIVEVGGTVGDIESLPFMEAIRQLAVEIGRERAMFMHLTLVPYLAAAGEVKTKPTQHSVKELLSIGIQPDILVCRSDRMIPANERKKIALFCNVPEKAVISMKDVDSIYKIPQLIKSQGLDDLVCARFGINAPEADLSEWEQVIYEEANPTGEVTIGMVGKYIELPDAYKSVNEALKHAGLKNRLSVNIKYVDSQDVETKGVEVLQGLDAILVPGGFGDRGIEGKILAAKYARENKVPYLGICLGMQVALIEYARNVAGMEGAHSTEFNKDTKYPVVGLITEWVDSEGNVEERTESSNLGGTMRLGSQLCHLAKGTKARELYGSDTIHERHRHRYEVNNNLRPQIEKAGLKVSGLSADKKLVEMIENPNHPWFVAAQFHPEFTSTPRDGHPLFSGFIKAAGENARGELK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.