PharMolix/UniProtQA huggingface dataset:
Protein: CATX_BACSU
Sequence: MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVTDNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDEPISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVGNNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGIPANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQDLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKNPENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPKKHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREAIDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKRVAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY
What is the function of this protein?
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
What are the official names of this protein?
Catalase X.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOK4_MOUSE
Sequence: MATNFNDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEKYPDEKSVCLRGCPKVTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEEWYKTLSVECLGSRLNDISLGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQITHENIYLWDIHNPRVKLVSWPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQIYQRVHSATLAIAEQHKRVLLEMEKNVRLLNKGTEHYSYPCTPTAMLPRSAYWHHITGSQNIAEASSYGESYGAAQASSETDLLNRFILLKPKPSQEDSSEAKTPAQ
What is the function of this protein?
DOK proteins are enzymatically inert adaptor or scaffolding proteins.  They provide a docking platform for the assembly of multimolecular signaling complexes.  DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity).  Putative link with downstream effectors of RET in neuronal differentiation.  May be involved in the regulation of the immune response induced by T-cells (By similarity).
What are the official names of this protein?
Docking protein 4, Downstream of tyrosine kinase 4.
What is the protein family that this protein belongs to?
Belongs to the DOK family. Type B subfamily.
Protein: YF021_YEAST
Sequence: MLLLFKNGKLLVKIKWSSKEDEQEVSRKLGKPEALCEARWEALSMSLSRSECTMECVSTSSSSSSSSNTFSKTEDPLRFMSERKNCWLSVSVSSRSLLPGPAAFTPLAKGEAEKSIIELECCIMRLIRWKDVRLCKRQERFKIRLESGNIFWALEYRSQISLFKFKSGSRFGTLFVLIVMFTTVHRVQCIYISIYIYAHAMNRTGEGRKSKGKKTCMLIPGPGVAHTYIYVAGPGTASVRLIVLLLLLLCIVVAVNTSGSCTGTNTMLRCFTSFCYVSACGRTQ
What are the official names of this protein?
Putative uncharacterized membrane protein YFL021C-A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GADW_ECO57
Sequence: MTHVCSVILIRRSFDIYHEQQKISLHNESILLLEKNLADDFAFCSPDTRRLDIDELTVCHYLQNIRQLPRNLGLHSKDRLLINQSPPMPLVTAIFDSFNESGVNSPILSNMLYLSCLSMFSHKKELIPLLFNSISTVSGKVERLISFDIAKRWYLRDIAERMYTSESLIKKKLQDENTCFSKILLASRMSMARRLLELRQIPLHTIAEKCGYSSTSYFINTFRQYYGVTPHQFAQHSPGTFS
What is the function of this protein?
Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC.  Repression occurs directly or via the repression of the expression of gadX.  Activation occurs directly by the binding of GadW to the gadA and gadBC promoters (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator GadW.
Protein: SBNA_STAAR
Sequence: MIEKSQACHDSLLDSVGQTPMVQLHQLFPKHEVFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLITENTHLIESTSGNLGIALAMIAKIKGLKLTCVVDPKISPTNLKIIKSYGANVEMVEEPDAHGGYLMTRIAKVQELLATIDDAYWINQYANELNWQSHYHGAGTEIVETIKQPIDYFVAPVSTTGSIMGMSRKIKEVHPNAQIVAVDAKGSVIFGDKPINRELPGIGASRVPEILNRSEINQVIHVDDYQSALGCRKLIDYEGIFAGGSTGSIIAAIEQLITSIEEGATIVTILPDRGDRYLDLVYSDTWLEKMKSRQGVKSE
What is the function of this protein?
Catalyzes the synthesis of N-((2S)-2-amino-2-carboxyethyl)-L-glutamate (ACEGA) from O-phospho-L-serine and L-glutamate.  Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics.
What are the official names of this protein?
N-(2-amino-2-carboxyethyl)-L-glutamate synthase, ACEGA synthase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.
Protein: LIPB_RICAH
Sequence: MLQFITIPNLMDYRVTLKLMEDYVNKVISDNELEVVYLVEHSEVYTAGTNYKQEELLNYGDIPVIYTGRGGKFTFHGPGQRVIYPILNLASPNRHKDLKLYIRMLEEWIINSLNYFGIKAYLIKDKVGIWVKVRKDEFAKIAAIGVRVRKWVTYHGVSINISTDLSKFRGIIPCGLENSLVTSLNQLGIHIEMSEFDKIIQNEFNKIFK
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIPIN_BOVIN
Sequence: MLEPQENGLTDLPDYEHIEDETFPPFPPPASPGREDGEGAEPEEESGRGAPVPVPPKRTVKRNIPKLNAERLISERGLPALRHVFEKAKFKGKGHEAEDLKTLIRHMEHWAHRLFPKLQFEDFIDRVECLGNKKEVQTCLKRIRLDLPILHEDFVSNNDEVEENNGHDVTATELDHFLTNSYGSVEFASESSRSLTEEEQQRIERNKQLALERRQAKLLSNSQSLGNDLSVNTPSTQTSEAGSTGEEQKEEESNGFNKDLLDSPHNAGAASTVNEEEQLKVEETQLDQSF
What is the function of this protein?
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.  Important for cell survival after DNA damage or replication stress.  May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.  Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
What are the official names of this protein?
TIMELESS-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the CSM3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: POL1_BPMV
Sequence: MKFYPGQNISEIVYHFQSNETANRLDAYFACGCEEDTEVLARLKQCNPRLLHLSYAAFCLEMGSHSIEEMEYDDGELIFSYFQNFLLSIVSNSSKTTKLRAYIRSAFAYHFQHFVEFDQYTNDSLNTVDTSVSAQGIADLALSMVRWIPTQIKKVVNFGVGSVIESFSEHFNKLLMQYCPIVFQAFSWVNNIWTMVKEWIEEAAKEISWFLQGCKELHAWGMCILASSCALGLVEKCLISLGMISESFDLVGLFVRSAIVGAFCVSIKTGKFVTNSELITCATIAVSTIATVMSQAFKPSEEIKGQFQALSVLEGLATQLTSFCDTSLVAMGKTCTAFNQICTAGKNVKVIAGRLLEVVSNFVRKLLGLDSAFLRDAALIFSQDVDGWLRNISWCQEQFLLKAYMSQDDLIVLRSLVVKGERMREQMLEGEVKVSPSVCNLIVKGCEEANKLMRESRLHCSKTIRKIPFVIFAHGESRVGKSLLVDRLITDFCDHLEIGEDAVYSRNPSDPFWSGYRRQPIVTIDDFAAVVSEPSAEAQLIPLVSSAPYPINMAGLEEKGMHFDSQIMMCSSNFLEPSPEAKIRDDMAFRNRRHVLITVELKPGVEYDESDFTKNQRYLLKTWFHYHYVVDQTFESYADLLAHCFTKWERHVKEQESNLSQIKGKKSESGHFYNFQQLMDLAVSWNLNADIMKNRIKAERNDMVYVFSAGRKDKILHCFLNKEGECTVRPDSIDDPEAQALLKASETMLMKAYAFLKYNNATNLIVRTHLAELVNEDFYDEKFNFIGTIGTPAFHRQIAAHLEKMPLWQKAILCGMGHCLSRKSKETWYTGMKEKFVQMMKSIYETEVTDWPVPLKIISGTILATILGTTFWKLFSFLRDAGNGGVFVGNVASAFTTSSVLEAQSRKPNRYEVSQYRYRNVPIKRRAWVEGQMSFDQSVVAIMSKCKASMRMGNTDAQILMVPGRRFIAHGHFFKNLTQKVRVQIVTSEKSYWHVYDPDKFQMFDNSEIGLYTNPTLEDIPHSAWDLFCWDSEKTLPNNFSAELLSCKLDTVTGQYYPRMAPINCRVHRQPIHITEGNYVRKQDVSIEYDACTIPNDCGSLVVAKVGNHKQIVGFHVAGSKGRLGYASLIPYVEPVVQAQSAEVYFDFFPVEVDSQEGVAHIGELKSGVYVPLPTKTNLVETPKEWQLDLPCDKIPSVLTTTDERLVGTEHEDMTHSWWYSKYATPMMPLDEEILSKVAQDMVEEWFDCVDEEDTFEEVSLSAALNGVEGLDYMERIPLATSEGFPHVLSRKNGEKGKRRFVTGDGEEMSLIPGTSVEEAYNKLTVELEKCVPTLVGIECPKDEKLPRRKIFDKPKTRCFTILPMEFNLVVRQKFLNFVRFIMKKRDKLSCQVGINPYSMEWTGLANRLLSKGNDILCCDYASFSGLITKQVMSKMAEMINSLCGGDEKLMRERTHLLLACCSRMAICKKDIWRVECGIPSGFPLTVICNSIFNEMLIRYSYEKLLRQAKAPSMFLQSFRNFISLCVYGDDNLISVHEYVKPYFSGSKLKSFLASHNITITDGIDKTSATLQFRKLSECDFLKRNFKQMSNVLWVAPEDKASLWSQLHYVSCNNLEMQEAYLVNLVNVLRELYLHSPEEARRLRRKALSCIEWLQKADVPTIAQIEEFHSMQRIMNAPDSNDNIDLLLSIDLLGLQGAARPSQIRLWFDDKLVLANTQEFFDGNFPADSWLPIFVNCLYPVSQLPAEAVIVNVVCGSGRGGLPTTAWISSAVNNRSSDINKKIRTALGKGKKIVFLTRVDPFPVALLAVLFGVKNEILSSNATNPMLTRLLENCKSLKYLVDECPFAFVN
What is the function of this protein?
Replicates the viral genome.
What are the official names of this protein?
RNA1 polyprotein, Genome polyprotein B, P1.
What are the subcellular locations of this protein?
[Putative helicase]: Host membrane; Single-pass membrane protein. Host cytoplasm, host perinuclear region. SUBCELLULAR LOCATION: [RNA-directed RNA polymerase]: Host endoplasmic reticulum. SUBCELLULAR LOCATION: [Protease cofactor]: Host cytoplasm, host perinuclear region.
Protein: RS18_MYCLB
Sequence: MAKSTKRRPAPEKPAKARKCVFCAKKNQQIDYKDTTLLRTYISERGKIRARRVTGNCVQHQRDIAIAVKNAREVALLPFTSSAR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TRPB_XANOP
Sequence: MSAQPISDFYAYPDAAGHFGKFGGRFVAETLIGPLQELSAAYDQARQDPSFIAEYDKDLKHYVGRPSPIYHAERLSREVGGAQILLKREDLNHTGAHKINNTIGQALLASRMGKTRIIAETGAGQHGVASATVAARLGLECLVYMGATDIERQKINVYRMKLLGATVIPVTSGSATLKDALNEAMRDWVTNVRDTFYIIGTVAGPDPYPRMVRDFNAIVGREARAQMLEDYGRLPDAISACVGGGSNAIGLFHAFLNDPGVKIYGAEAAGDGIATGRHAASIAAGRPGVLHGNRTYVICDDDGQITETHSISAGLDYPGVGPEHAFLSDSGRAVYQGITDDEAMAAFHLLAHTEGILAALESSHAVAQSIKLARELPKDALVLCNLSGRGDKDVHTIAAREGLAL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RECX_PSEFL
Sequence: MTVVLDTLVAVRRTAMDLLARREHGRVELTRKLRQRGAEPEMIETALDRLTEEGLLSEARYLESFVSYRARSGYGPARIREELSQRGLQRADIDLALRECGISWQSQLEDTWRRKFAGHLPIDARERAKQGRFLSYRGFSMDMISRLLSGRDMDD
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYF_ANTAG
Sequence: MQNRKTYAYDWIKKWMIKSISTLIIINTMVWSSVSEAYPIFAQQGYENPREATGRIVCANCHLAKKPVDIEVPQSVLPDTVFEAVVKIPYDTQVKQVLANGKKGALNVGAVLILPEGFELAPSNRVPPEMKEKIGNLYFQSYRPDKKNILVVGPVPGKKYSEIIFPILAPNPATNKDAHFLKYPIYVGGNRGRGQIYPDGSKSNNTVYNASTTGIIKKVLRKEKGGYEIIIDNTLDGRQVIDIVPPGPELIISEGESIKVDQPLTNNPNVGGFGQGDAEIVLQDVLRVQGLLLFFASVILAQIFLVLKKKQFEKVQLAEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FPG_BRUAB
Sequence: MPELPEVETVRRGLQPFMEGATVVRVEQNRPDLRFAFPENFAERLSGRRIEALGRRAKYLTVHLDDGLSIISHLGMSGSFRIEAEDAQGLPGGFHHERSKNSLHDHVVFHLMRPDGASARIIYNDPRRFGFMLFAEKGALEEHPLLKDLGVEPTGNLLSGEVLAALFKGRRTPLKAALLDQRLIAGLGNIYVCEALWRPGLSPMRAAGSVAGEMDVMERLAGAIRSVIAQAIAAGGSSLKDYIQADGALGYFQHSFSVYGREGKPCRNPACGGTVERVVQSGRSTFFCASCQT
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: TRHO_ECOLC
Sequence: MPVLHNRISNDALKAKMLAESEPRTTISFYKYFHIADPKATRDALYQLFTALNVFGRVYLAHEGINAQISVPASNVETFRAQLYAFDSALDGLRLNIALDDDGKSFWVLRMKVRDRIVADGIDDPHFDASNVGEYLQAAEVNAMLDDPDALFIDMRNHYEYEVGHFENALEIPADTFREQLPKAVEMMQAHKDKKIVMYCTGGIRCEKASAWMKHNGFNKVWHIEGGIIEYARKAREQGLPVRFIGKNFVFDERMGERISDEIIAHCHQCGAPCDSHTNCKNDGCHLLFIQCPVCAEKYKGCCSEICCEESALPPEEQRRRRAGRENGNKIFNKSRGRLNTTLGIPDPTE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis.  May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: PG144_VAR67
Sequence: MSYLRYYNMLDDFSAGAGVLDKDLFTEEQQQSFMPKDGGMMQNDYGGMNDYLGIFKNNDVRTLLGLILFVLALYSPPLISILMIFISSFLLPLTSLVITYCLVTQMYRGGNGNTVGMSIVCIVAAVIIMAINVFTNSQIFNIISYIILFILFFAYVMNIERQDYRRSINVTIPEQYTCNKPYTAGNKVDVDIPTFNSLNTDDY
What is the function of this protein?
Envelope protein which participates in virus morphogenesis.  Needed for an early step in viral crescent membrane formation by interacting with OPG125 scaffold protein.  Its interaction with OPG125 scaffold protein leads to the formation of rigid, crescent-shaped membranes that assemble around the cytoplasmic virus factory.  Acts as a membrane anchor for the protein OPG154.  OPG144-OPG154 virus envelope protein might be involved in fusion or attachment, and can further associate with OPG153.
What are the official names of this protein?
Virion membrane protein OPG144 precursor, 23 kDa late protein.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG144 family.
Protein: CLCN3_PONAB
Sequence: MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTVTLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN
What is the function of this protein?
Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity).  The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity).  The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).
What are the official names of this protein?
H(+)/Cl(-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
What are the subcellular locations of this protein?
Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RS19_STREM
Sequence: MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSFIGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: Y434_METTH
Sequence: MNMVVIGVTGMPGAGKGVVSRIAESMGFRVIRMGDVIRDEARKRGEDPGVTAVRLREEYGKYVVAEKCVERIQESESEMFLIEGIRSPHEVEIFRKRFPGFRVISVFSTRKTRFRRLRKRQREDDSQRYAEFVERDERELGFGIGDVIATSDYMIVNEGPIWKIKKQAKQILRKLAEKGEESSRGGQEDG
What are the official names of this protein?
UPF0200 protein MTH_434.
What is the protein family that this protein belongs to?
Belongs to the UPF0200 family.
Protein: LIPB_PROMP
Sequence: MINRTSIIKQPDKISFFYDVYKLQKEYQDSLISGKSNMNFIWLGEHQLCYTVGRGSNMDNLLFSADEQDVFKIDRGGEVTCHMPGQLVTYLVLDLSNLNKDLNWYLRKIEKIIIKTLRSFNINCSTKDGFTGVWIGERKIASIGIGCKRWVTIHGFSINVNCKLENFNKIVPCGIKGCQMVNMSDYNKNVDIKEVKKIVKKIIHEEFNFNFVSE
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: X_GSHV
Sequence: MAARLCCQLDSSRDVLLLRPLRGQPSGPSVSGTSAGSPSSAASAFSSGHQADIPVGRLPACFYSSAGPCCLGFTCADLRTMDSTVNFVPWHAKRQLGMMQKDFWTAYIRDQLLTLWEEGIIDPRLKLFVLGGCRHKYM
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: RL15_BURMS
Sequence: MELNNLKPAEGAKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFTSLTKEFVGEVRLGDLEKLPVDEIDLLALKQAGLVGELIKSAKIIATGELKRKIVVKGLGATKGARAAIEAAGGSFAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL2_ECO7I
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: HFE_MOUSE
Sequence: MSLSAGLPVRPLLLLLLLLWSVAPQALPPRSHSLRYLFMGASEPDLGLPLFEARGYVDDQLFVSYNHESRRAEPRAPWILEQTSSQLWLHLSQSLKGWDYMFIVDFWTIMGNYNHSKVTKLGVVSESHILQVVLGCEVHEDNSTSGFWRYGYDGQDHLEFCPKTLNWSAAEPGAWATKVEWDEHKIRAKQNRDYLEKDCPEQLKRLLELGRGVLGQQVPTLVKVTRHWASTGTSLRCQALDFFPQNITMRWLKDNQPLDAKDVNPEKVLPNGDETYQGWLTLAVAPGDETRFTCQVEHPGLDQPLTASWEPLQSQAMIIGIISGVTVCAIFLVGILFLILRKRKASGGTMGGYVLTDCE
What is the function of this protein?
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
What are the official names of this protein?
Hereditary hemochromatosis protein homolog.
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: KDSA_XYLFT
Sequence: MKLCGFEVGLNQPLFLIAGPCVIESLQLQLDTAGVLKEITSKLGLNFIFKSSFDKANRTSGSSFRGPGLEEGLKVLEAVKTQIGVPVLTDVHEYTPIDEVATVVDVLQTPAFLVRQTDFIRNVCAVGKPVNIKKGQFLSPWDMKPVVEKAKSTGNSQILVCERGASFGYNNLVSDMRSLAVMRETGCPVVFDATHSVQLPGAQGGRSGGQREFVPVLARAAVAVGISGLFAETHPDPPNALSDGPNAWPLRTMAMLLETLVELDAVTKKRGFLEQD
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA_INCJJ
Sequence: MSKTFAEIAETFLEPEAVRIAKEAVEEYGDHERKIIQIGIHFQVCCMFCDEYLSTNGSDRFVLIEGRKRGTAVSLQNELCKSYDLEPLPFLCDIFDREEKQFVEIGITRKADDSYFQSKFGKLGNSCKIFVFSYDGRLDKNCEGPMEEQKLRIFSFLATAADFLRKENMFNEIFLPDNEETIIEMKKGKTFLKLRDESVPLPFQTYEQMKDYCEKFKGNPRELASKVSQMQSNIKLPIKHYEQNKFRQIRLPKGPMAPYTHKFLMEEAWMFTKISDPERSRAGEILIDFFKKGNLSAIRPKDKPLQGKYPIHYKNLWNQIKAAIADRTMVISENDHSEFLGGIGRASKKIPEVSLTQDVITTEGLKQSENKLPEPRSFPKWFNAEWMWAIKDSDLTGWVPMAEYPPADNELEDYAEHLNKTMEGVLQGTNCAREMGKCILTVGALMTECRLFPGKIKVVPIYARSKERKSMQEGLPVPSEMDCLFGICVKSKSHLNKDDGMYTIITFEFSIREPNLEKHQKYTVFEAGHTTVRMKKGESVIGREVPLYLYCRTTALSKIKNDWLSKARRCFITTMDTVETICLRESAKAEENLVEKTLNEKQMWIGKKNGELIAQPLREALRVQLVQQFYFCIYNDSQLEGFCNEQKKILMALEGDKKNKSSFGFNPEGLLEKIEECLINNPMCLFMAQRLNELVIEASKRGAKFFKID
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.