Protein: PAT3_CAEEL
Sequence: MPPSTSLLLLAALLPFALPASDWKTGEVTGKVVEKSEFPCYSLSRDNYTCSACIQYHESCAWCGAPMFDEKKPYARCDSRAKLMEHGCPNSYIEDPATKLDITEDSKLSDQGQVESEEEAVQIKPQEMYVEIRPKSRVRFNVTYRQAVDYPVDLYYLMDLSYSMKDDKQKLSELGDLLAERMRTVTKNFRLGFGSFIDKKLMPFIDPRIEKQLSPCPTPCAEPYGFKHQMSLTTNTAKFKAEVDKAEISGNLDAPEGGFDAVVQALACNKTIGWRERARKMIVFSTDAGFHFAGDGRLAGVVEPNDGTCHLDREGYYTETLNQDYPSIALLHQMIKDRKANVIFAVTKNNQDLYTQLSNALPDVSSSVGVLANDSRNIVDLIEKEYLKISEKIIMVDNANASEGLKLTYRSMCLDGTTLKDTNVCEGIRVGDEVQFEVTLENTHCIDKRDFVLRIGPSGLDETLIVNVKVLCDCDCERQDRIVTNSADCNGGDMVCGVCRCKGGNVGKYCECNRPGMSTAALNEKCKRTNESAICEGRGVCNCGRCECNPRANPEEQISGEFCECDNFNCPRHDRKICAEHGECNCGKCICAPGWTGRACECPISTDSCLSANGKICNGKGECICGRCRCFDSPDGNRYSGAKCEICPTCPTKCVEYKNCVMCQQWQTGPLNETACDQCEFKVIPVEELPNLNETTPCQFVDPADDCTFYYLYYYDEATDNATVWVRKHKDCPPPVPVLAIVLGVIAGIVILGILLLLLWKLLTVLHDRSEYATFNNERLMAKWDTNENPIYKQATTTFKNPVYAGKAN
What is the function of this protein?
Integrin alpha ina-1/beta pat-3 is a receptor for laminin.  Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable).  Plays a role in cell migration, morphogenesis and probably in cell-cell interactions (PubMed:19023419, PubMed:17326220, PubMed:23283987).  During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed:19023419).  Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611).  Involved in the assembly of dense bodies and M lines during body wall muscle embryonic development by recruiting one of their components, cpna-1, to integrin-mediated attachment sites (PubMed:23283987).  May play a similar role in the assembly of dense bodies in gonadal myoepithelial sheath cells (PubMed:17326220).  Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).  Required for ovulation (PubMed:17326220).  Dephosphorylated, probably within the alpha pat-2/beta pat-3 integrin receptor complex, by the phosphatase dep-1, which leads to down-stream effects including the negative regulation of let-23 signaling and vulval induction (PubMed:28135265).  When unphosphosphorylated, recruits the cytoplasmic adapter protein tln-1 to the plasma membrane of secondary vulval precursor cells (PubMed:28135265).  This promotes the linking of focal adhesion sites to the F-actin cytoskeleton, and it also acts to restrict the mobility of the let-23 receptor on the plasma membrane of vulval cells which thereby attenuates let-23 signaling (PubMed:28135265).  Plays a role in axon regeneration after injury (PubMed:31109965).
What are the official names of this protein?
Integrin beta pat-3, Paralyzed arrest at two-fold protein 3.
What is the protein family that this protein belongs to?
Belongs to the integrin beta chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Lateral cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cytoplasm, myofibril, sarcomere, M line. Cell junction, focal adhesion. Note=In body wall muscle cells localizes to the base of thick filament M-lines, dense bodies (Z-disks) and in adhesion plaques which form between adjacent cells (PubMed:22479198, PubMed:20385102). In body wall muscles, colocalizes with cpna-1 at integrin adhesion structures (M line and dense bodies) (PubMed:23283987). Decreased localization to dense bodies during the L2/L3 molt (PubMed:20385102). In myoepithelial sheath cells, colocalizes in dense bodies-like structures with actin thin filaments, deb-1/vinculin and unc-52 (PubMed:17326220).