PharMolix/UniProtQA huggingface dataset:
Protein: PSAB_HETTR
Sequence: MSLLDGRILGFTTHSDSFVSKRQSNGAATGRFFQVIGNIHDIESYYGIHGSQVNLQIFLSHFGHLAIIFLWAAGNLFHIGWNGNYELWILNPISTMPIAHGIWDPHFGAQGEAVWGGVSATSGGSEAVVVSYSGIYNWLYAVGFTSVYEIYNFVIVLELLAVAALLLGKTHLIYNEELIQWLGTNKPYYRVGSDNEEVVSLYKKLALDMKVYPMFIWPFRIFLAAFDASGLRLNFHIGALIGFTSLAWAGHLIHVAIPASRGIYHTISPVGDSTFAEPSLKALYPFYSGNWAYYAQDIDKDNHIFGSTVGAGKAILTFLGGVKSDTASLYLTDIAHHHLAIGVLFIWAAHLYSSLYKGFGHRIRDILVSANSGMMIRSMNSYHLQLALACAGVSVITSVVGQHIYSLAPYPYLAYDYVTTVALYLHHSWIASLLMMAAFAHAGIFLVRDYTVNPKTTTGEDIIGRVLAHKAAIISHLSWVSLWLGFHTLGVYIHNDTVTAFGEPQNSILIEPIFAQIIQSASGKTLYGTTLFSVVNPSSGWVQSVNKSFGSLLLPIGPGDLLAHHAIALGLHVTVLILMKGALDARGSKLMPDKIHFGYGFACDGPGRGGTCDISAWDSFYLAMFWMLNTNAWTIFYFHWKELTLWQNITFQFDESSNYLNGWFRDYLWFNSGSLIRGYDALGANDLSVWAWIFLAAHLCWATGFMFLISWRGYWQELIDIILYMHLKTPILYDIWNAGVYTPVALSIVQARFIGLVHFAVGFIITYAAFIVGSTT
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 (By similarity).
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: METAS_PHOPR
Sequence: MPIKIPDRLPATDILRSENIFVMSEARAATQGIRPLKVLLLNLMPKKIETETQFLRLLSNSPLQVDVELLRIDNRPTKNTPTEHLDTFYRQFEMVKDRNFDGLIVTGAPLGLVQFEDVLYWEEIQVIMNWAKEHVTSTMFVCWAAQAGLKLLYDLPKRTRKEKISGVYEHKIHDRHHPLLRGFDDLFKAPHSRYADFSPSYLAEHTDLDILATSEVAGVYLASTKDKRNVFVTGHPEYEVDTLHHEYIRDCEQGIEPNMPVNYYPDNNASNTPVASWRSHGHLLFSNWLNYCVYQQTPYDLDDFSEANFTKNDE
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_BACCZ
Sequence: MKEIKVIIAGPRGRMGHEAVLLMERTEHFNLVAAVDYKHGGEKISDLPGMPALDAPIYADLHTCLEEVEADVLLDLTTPEVGKQHVTLAVERGLRSVIGTTGFTEEELKQLTEIAKEKAVGTIIAPNFAIGAVLMMKFSQMAAKYFQDVEVIELHHDQKLDAPSGTAVKTVELIRQNRESKQQGHPNEVEQLEGARGANVDGIHIHSVRLPGLIAHQEVMFGGDGQMLTVRHDSFNRASFMSGVKLSIETVMNLDHLVYGLENIID
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLAC9_HUMAN
Sequence: MRPLLCALTGLALLRAAGSLAAAEPFSPPRGDSAQSTACDRHMAVQRRLDVMEEMVEKTVDHLGTEVKGLLGLLEELAWNLPPGPFSPAPDLLGDGF
What are the official names of this protein?
Placenta-specific protein 9.
What is the protein family that this protein belongs to?
Belongs to the PLAC9 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MET16_SCHPO
Sequence: MSSIDTPANKLQAKTLFHPEHLEYINKQLSELSPQDILKWCRWTLPSLFQTSALGLSGLVIMDMLSKMDMNVPLIFINTLHHFPETLDLLEKVKTKYPNVPVHVYRCAEAANEKEFAQKFGEKLWETDESRYDFLVKVEPASRAYSDLNVLAVFTGRRRSQGGERGSLPIVQLDGPVLKINPLANWSFTEVHNYIITNNVPYNELLNKGYRSVGDWHSTQPVREGEDERAGRWRGREKTECGLHSHPQSKFAQYMAELKKKETADQ
What is the function of this protein?
The NADP dependent reduction of PAPS into sulfite involves thioredoxin which probably plays the role of a thiol carrier (By similarity).  Required for methionine synthesis.
What are the official names of this protein?
Probable phosphoadenosine phosphosulfate reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FIS1_ASPFU
Sequence: MPTLNYPDSSPLKPAELQVLRAQYEKEGDYVGIQTKFNYAWGLIKSNARTDQQEGVRLLSEIFRAAPERRRECLYYLALGNYKLGNYGEARRYNDLLLEKEPGNLQAASLGSLIDDKVSKEGLMGIAIVGGLALAAGIVGGLVFKGAAKRR
What is the function of this protein?
Has a role in mitochondrial fission.  Has a role in outer membrane fission but not matrix separation (By similarity).
What are the official names of this protein?
Mitochondrial fission 1 protein.
What is the protein family that this protein belongs to?
Belongs to the FIS1 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: MNMC_SHIB3
Sequence: MKHYSIQPANLEFNAEGTPVSRDFDDVYFSNDNGLEETRYVFLGGNQLEVRFPEHPHPLFVVAESGFGTGLNFLTLWQAFDQFREAHPQAQLQRLHFISFEKFPLTRADLALAHQHWPELAPWAEQLQAQWPMPLPGCHRLLLDEGRVTLDLWFGDINELTSQLDDSLNQKVDAWFLDGFAPAKNPDMWTQNLFNAMARLARPGGTLATFTSAGFVRRGLQDAGFTMQKRKGFGRKREMLCGVMEQTLPLPCSAPWFNRTGSSKREAAIIGGGIACALLSLALLRRGWQVTLYCADEAPALGASGNRQGALYPLLSKHDEALNRFFSNAFTFARRFYDQLPVKFDHDWCGVTQLGWDEKSQHKITQMLSMDLPAELAVAVEANAVEQITGVATNCSGITYPQGGWLCPAELTRNVLELAQQQGLQIYYQYQLQNLSRKDDCWLLNFAGDQQATHSVVVLANGHQISRFSQTSTLPVYSVAGQVSHIPTTPELAELKQVLCYDGYLTPQNPANQHHCIGASYHRGSEDTAYSEDDQQQNRQRLIDCFPQAQWAKEVDVSDKEARCGVRCATRDHLPMVGNVPDYEATLVEYASLAEQKDEAVSAPVFDDLFMFAALGSRGLCSAPLCAEILAAQMSDEPIPMDASTLAALNPNRLWVRKLLKGKAVKAG
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEG1_PONAB
Sequence: MACGLVASNLNLKPGECLRVRGEVTPDAKSFVLNLGKASNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQTNLTIKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
What is the function of this protein?
Lectin that binds beta-galactoside and a wide array of complex carbohydrates.  Plays a role in regulating apoptosis, cell proliferation and cell differentiation.  Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.  Strong inducer of T-cell apoptosis.
What are the official names of this protein?
Galectin-1, Gal-1, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, S-Lac lectin 1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: RARD_SALTI
Sequence: MDAKQTRQGVLLALAAYFIWGIAPAYFKLIYYVPADEILTHRVIWSFFFMVALLSVSRQWRQVKRLLKTPKKIFLLALSAVLVGGNWLLFIWAVNNHHMLEASLGYFINPLVNILLGMIFLGERFRRMQWLAVILAVCGVLVQLWTFGSLPIIALGLAFSFAFYGLVRKKIAVEAQTGMLVETLWLLPVAAIYLFSIADSATSHMGQNALSLNLLLMAAGVVTTIPLLCFTGAATRLRLSTLGFFQYIGPTLMFLLAVTFYGEVPGADKMVTFAFIWVALAIFVMDAIYTQRKK
What are the official names of this protein?
Protein RarD.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: I17RE_RAT
Sequence: MGSPRLAALLLSQPLLFICLAVSAQVACPCLPRWTSHCLLAFRVDKHFAGLQCGWFPLLVRKSKSSHEFEVCWRHWTPSPFQRKLLGSPSLSQESHRISTHFLAISHRGLRTKRTQPSAAEGIEHLPGAGSQKHGGPEFSFDLLPEVQAIRVTIPPGPEANVRLCYQWALECEDMSSPFDTQKIVSGGHTVDLPYEFLLPCMCIEASYLQEDTVRHKKCPFRSWPEAYGSDFWKSIRFTDYSQHSQMVMALTLRCPLKLEASLCWRQDPVTPCKILPNATAKESEGWYILENVDLHPQLCFKFSFENSSHVECPHQSGSLPSWTVSMDTQAQQLILHFSTRTYATFSAAWSNPGLGLDSSMTPVYSISQTQGSVPVTLNLIIPFLRQGSCILVWRSDVQFAWKHLLCPDVSHRHLGLLILALLGLTTLLGVVLVLFCRRLLPGPGRTRPVLLLHAADSEAQRRLVGALAELLRTALGGGRDVIVDLWEGTHVARIGPLPWLWAARERVAREQGTVLLLWSCAGPSTACSGDPQTASLRTLSCAAPRQLLLAYFSRLCAKGDIPGPLRALPRYRLLRDLPRLLRALDARPATLATSWSHLGAKECLKSRLELCHLLELEAAKDDYHGSTNSPCGFSCL
What is the function of this protein?
Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways.  Requires TRAF3IP2 /ACT1 for signaling.  Crucial regulator in innate immunity to bacterial pathogens (By similarity).
What are the official names of this protein?
Interleukin-17 receptor E, IL-17 receptor E, IL-17RE.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: M1_I77AB
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEAAFGLICATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRAIGTHPSSSAGLKNDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: MUCA_ECOLX
Sequence: MKVDIFESSGASRVHSIPFYLQRISAGFPSPAQGYEKQELNLHEYCVRHPSATYFLRVSGSSMEDGRIHDGDVLVVDRSLTASHGSIVVACIHNEFTVKRLLLRPRPCLMPMNKDFPVYYIDPDNESVEIWGVVTHSLIEHPVCLR
What is the function of this protein?
Involved in UV protection and mutation.
What are the official names of this protein?
Protein MucA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: GPMI_BACAH
Sequence: MRKPTALIILDGFGLREETYGNAVAQAKKPNFDGYWNKFPHTTLTACGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFDKNETFQSAIKSVKEKGTALHLFGLLSDGGVHSHMNHMFALLRLAAKEGVEKVYIHAFLDGRDVGPKTAQSYIDATNEVMKETGVGQFATISGRYYSMDRDKRWDRVEKCYRAMVNGEGPTYKSAEECVEDSYANGIYDEFVLPSVIVNEDNTPVATINDDDAVIFYNFRPDRAIQIARVFTNEDFREFDRGEKVPHIPEFVCMTHFSETVDGYVAFKPMNLDNTLGEVVAQAGLKQLRIAETEKYPHVTFFFSGGREAEFPGEERILINSPKVATYDLKPEMSIYEVTDALVNEIENDKHDVIILNFANCDMVGHSGMMEPTIKAVEATDECLGKVVEAILAKDGVALITADHGNADEELTSEGEPMTAHTTNPVPFIVTKNDVELREGGILGDIAPTMLTLLGVEQPKEMTGKTIIK
What is the function of this protein?
Essential for rapid growth and for sporulation.  Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: RBMS3_PONAB
Sequence: MGKRLDQPQMYPQYTYYYPHYLQTKSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQTVAPSSQDTSGQQQQIAVDTSNEHAPAYSYQQSKP
What is the function of this protein?
Binds poly(A) and poly(U) oligoribonucleotides.
What are the official names of this protein?
RNA-binding motif, single-stranded-interacting protein 3.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI26_RAT
Sequence: MAVSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTSDIRPISGNRPVCPLCKKPFKKENIRPVWQLASLVENIERLKVDNGKQPGELAREPQDMKLCERHQEKLHYYCEDDGKLLCVMCRESREHRPHTAVLVEKAALPHREKILNHLNTLRRDRDKIQGFQAKGEADILAALTKLQEQRQYIVAEFKQGHQFLKKREQHLLDQLATLEQLLTEGREKFKTRGVSELDRLTLVISELEGKARQPAAELMQLSDRLSCLSLRYPRKKFWIGKAIPHMVKRKAGEFSDKLLSLQRGLRQFQGKLLRDLEYKTVSVTLDPQSASGYLQLSEDWKCITYTGQYQSDCLLPQQFDCEPGVLGSKGFTWGKVYWEVELEREGWSEDEEEGEEEEEGEEEEEDEEPGYGDRYEDWETDEEDESLGEEEEEEEEEEEEVQESCMVGVAKDSVKRKGNLSLRPEDGVWALRLSPSGIWANTSPEAQLFPVLRPRRVGIALDYEGGTVTFTNAESQELIYTFTTTFTRRLVPFLWLKWPEARLLLRP
What is the function of this protein?
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs).  Promotes nuclear IRF3 ubiquitination and proteasomal degradation.  Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.
What are the official names of this protein?
Tripartite motif-containing protein 26, Zinc finger protein 173.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Viral infection mediates TRIM26 nuclear translocation.
Protein: DAPA_RALSO
Sequence: MTQISGSLVAIVTPMHEDGSLDFPSLRSLIDWHIAEGTDGIVIVGTSGESPTVSVDEHRELIRVTVEQVNKRIPVIAGTGGNSTTEAVELTAYAKSVGADASLQVVPYYNKPTQEGMYLHFRKVAESVDLPVILYNVPGRTVADMSVDTMLRLAQVPGVMGVKEATGNIDRAAQLIKAAPASFKIYSGDDPTAVALMLLGGHGNISVTANVAPRAMHDLCAAAMRGDVETARRIHMQLLSVHKNLFVESNPIPVKWALQAMGKMAGGIRLPLTPLAAQYQEVVRASLQDAGLLS
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A1H2_LOXRE
Sequence: MLLYVTLILGCWSAFSESAETDVAERANKRPIWIMGHMVNAIYQIDEFVNLGANSIETDVSFDKDANPEYTYHGVPCDCGRSCLKWEYFSDFLKGLRKATTPGDSKYHAKLVLVVFDLKTGSLYDNQAYDAGKKLAKNLLKHYWNNGNNGGRAYIVLSIPDLNHYKLITGFKETLKSEGHPELMDKVGHDFSGNDAIGDVGNAYKKAGVTGHVWQSDGITNCLLRGLSRVKEAVKNRDSSNGFINKVYYWTVDKRATTREALDAGVDGVMTNYPDVITDVLNESAYKAKFRIATYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (PubMed:15926888).  It also acts on a broad range of lysophospholipids, like lysophosphatidylinositol (LPI), lysophosphatidylglycerol (LPG), lysophosphatidylethanolamine (LPE), lysobisphosphatidic acid (LBPA), lysophosphatidylserine (LPS) and lysophosphatidylcholines (LPC) of varying chain lengths (PubMed:15926888).  The substrate preference is LPI > LPG > LPS > LPC >> LPE, LBPA (PubMed:15926888).  Furthermore, the enzyme also act on cyclic phosphatidic acid and lyso-platelet activating factor (LPAF, an alkyl-LPC) (PubMed:15926888).  The enzyme does not act on sphingosylphosphorylcholine (SPC, also known as lyso-sphingomyelin) and PAF (PubMed:15926888).  The toxin may also act on ceramide phosphoethanolamine (CPE) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  It does not exhibit detectable PLA1/2 activity (PubMed:15926888).  It induces dose-dependent hemolysis and dermonecrosis (PubMed:15926888).  Also induces increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LrSicTox-alphaIA1ii, Dermonecrotic toxin, Phospholipase D, PLD, SMaseD/LysoPLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily. Class IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GSIB_SALCH
Sequence: MTQFITHKWLAALGLASSIAAFPALAAKDVVVAVGSNFTTLDPYDANDTLSQAVAKSFYQGLFGLDKDMKVKNVLAEGYTVSDDGLTYTITLRRGVKFQDGADFNAAAVKANLDRASNPDNHLKRYNLYKNIAKTEVVDPATVKITLKQPFSAFINILAHPATAMISPQALEKYGKDIGFHPVGTGPYQLETWNQTDFVKVKKFAGYWQQGLPKLDSITWRPVTDNNTRAAMLQTGEAQFAFPIPYEQAALLAKNKNLELVASPSIMQRYISMNVTQKPFDNPKVREALNYAINRQALVKVAFAGYATPATGVVPPSIAYAQSYQPWPYDPAKARELLKEAGYPDGFSTTLWSSHNHSTAQKVLQFTQQQLAQIGIKARITAMDAGQRAAEVEGKGQKESGVRMFYTGWSASTGEADWALSPLFASQNWPPTQFNTAFYSNKQVDSDLAAALKTNDPQEKTRLYKEAQDIIWKESPWIPLVVEKLVSAHSKNLTGFWIMPDTGFSFDDADLK
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Binds glutathione.
What are the official names of this protein?
Glutathione-binding protein GsiB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 5 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL13_BACC3
Sequence: MRTTFMAKANEVERKWYVVDAEGQTLGRLASEVASILRGKNKPTFTPHVDTGDHVIIINAEKIHLTGNKLNDKIYYRHTNHPGGLKQRTALEMRTNYPVQMLELAIKGMLPKGRLGRQVSKKLNVYAGAEHPHQAQKPEVYELRG
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ATG4_PICGU
Sequence: MTWDTKNQFETTKTSQELPATSQDHISDNKMNSEPSHRLSQFWSSLTRSSSESITAEPVVILGHTYREGDRDREGDSEVQKQVKKRYWMSYRSGFEPIKKHEDGPSPLSFVQSMIFNKNVGNTFANIHSLVDNDNFTTDVGWGCMIRTSQSVLANAIDRAGYEVDVELFADTSSAAFSLHNFVKVASDSPLRVRPGQWFGPSAASLSIKRLCEARNSSTNVPLSVLVCESGDIYDDQIQTFPVLLLLPLRLGIDHVNNVYHSSLLQLLEVPQSAGIAGGKPSSSLYFFGYQGTSLLYLDPHYPQNVSAGVGSYHSSSYQKLDISDMDPSMMAGIVLKNNEDYTDLKRRTTGNKIIHFHEARNYNDYVEVEREDFIDLGQNNRSATAGAEADFDSESSMVIVD
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: ACES_CHICK
Sequence: MAPLFLLLLLLLSPSPTSAHRFAYSAPNRPEVRTTTGSVRGLLIPAGPSGSTAAAFLGIPFAVPPLGPLRFRPPLPIPTPWTGIRDADSQPFACYQMVDTTFPGFQGSEMWNPNREMSEDCLYLNVWTQKGDPTEPPVLVWIYGGGFTGGSVSLDVYDGRYLAAAEEAVVVSMNYRVGSLGFLALAGHRDAPGNVGLWDQRLALQWVRDNAEAFGGDPDLITLFGESAGAASVGFHLLSPHSKGLFRRAVLQSGSPNGPWATIGAAEGRRRAAALGRAVGCPYGNETEFLGCLRGKEAADVLEGEGVVMPPQSVFRFAFVPVVDGDFVVDSPDVALWGDYGVKGGEGGHGVEGGDGGYGVKGGDGVKGGYGGGYGARGVREGDGDGGYGVKEGLREGYGVKEGYGVEGDGANAYGARVPPRPHRDETPPDAYGAKGSADAYGAKAAPRPHRDETSPDAYGAKMPPRPHRDEASPDTYGAKMPPRPHRDETSPDAYGAKMPPRPHRAGGEVEVLLGAVRVEGSYFLVYGVPGFGKDNESLISREEFLGGVRMGVPQATELAAEAVVLHYTDWLDADNPVKNREALDDIVGDHNVVCPLMAFAQRWAQRGGKVYAYLFDHRSSTLLWPSWMGVPHGYEIEFVFGLPLEPRNNYTREEVELSRRIMRYWGNFARTGDPNGGVGGPRWPPYTPSGQRYAHLNARPLSVGHGLRTQICAFWTRFLPKLLNATGPPEDAEREWRLEFHRWSSYMGRWRTQFEHYSRQQPCATL
What is the function of this protein?
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
What are the official names of this protein?
Acetylcholinesterase, AChE.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Synapse. Secreted. Cell membrane; Peripheral membrane protein.
Protein: ATP6_STRPQ
Sequence: MEEAKIPMLKLGPITFNLTLLAVCIVTIAVIFAFVFWASRQMKLKPEGKQTALEYLISFVDGIGEEHLDHNLQKSYSLLLFTIFLFVAVANNLGLFTKLETVNGYNLWTSPTANLAFDLALSLFITLMVHIEGVRRRGLVAHLKRLATPWPMTPMNLLEEFTNFLSLAIRLFGNIFAGEVVTGLIVQLANYRVYWWPIAFLVNMAWTAFSVFISCIQAFVFTKLTATYLGKKVNESEE
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: F16PA_PASMU
Sequence: MKTLGQFIVEKQAEYPNAKGELSGILSSIRLVAKVIHRDINKAGLTNNIIGTSGAENVQGETQMKLDLFAHNTMKQALISREEVAGFASEEEENFVAFDTERGRNAKYVILTDPLDGSSNIDVNVAVGTIFSIYRRVSPIGTPVTLADFMQPGNRQVAAGYIVYGSSTMLVYTTGNGVNGFTYDPSLGVFCLSHENIQIPANGKIYSINEGQYLKFPQGVKKYIKYCQEEDKATHRPYTSRYIGSLVSDFHRNMLKGGIYIYPSATNYPNGKLRLLYEGNPMAFLAEQAGGMASDGYQRILDIQPTELHQRVPLFLGSKEMVEKAQDFMKTFG
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQA_PSEPW
Sequence: MWTKPAYTDLRIGFEVTMYFASR
What is the function of this protein?
Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis.  PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide.
What are the official names of this protein?
Coenzyme PQQ synthesis protein A, Pyrroloquinoline quinone biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the PqqA family.
Protein: CH10_SYNP2
Sequence: MAAISINVSTLKPLGDRVFVKVSESEEKTAGGILLPDSAKEKPQIGEVVAVGEGKRNDDGSRSAVDVKVGDKVLYSKYAGTDIKLSGDDYVLLSEKDILATVA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.