Protein: ACLP_ASPOR
Sequence: MPLSGWPKGGYEVRLWYVHVPERYFIYMAADWNPRHAPINIGYPSRTTMNPSSQLLVQQLAAVLEVDTAELDLNSGFVHNGGNSLSAVEFVSRSKSLGVSLSIASILSSTNLRALFTDLLSSESNLIPIPDPSDDSDDLSNPSSSTGGSPRVATPISSNVSTAAEDDYLTQGSVLTQYATQSLSEMQASLLHGSLKSPGTNIIYHYETYQTDVIPVLKRAWKTVIEGEPIFHSSLLDGSARNQEYFTWSEVTVETEAEYREQLQTLWLKSVSSSFKVVHWKRSPPASSQSTVIWAVHHALVDGYSAMLLFCKVRRAIKGLPIVPGPSFSDVEKRIRVWRQEHKSQGDEYWAGHAAQLDQAQGELLLPAPTPEGTSSAITESEEVYVAPSVSNTQLHCVAKRLGVTLSTCYYAAWSLVLSLYADSASVVFGAVLAGRNLPLEGVDEVVGPLVNTLPLCLTLSRQQSAQDFLKNLFSRMVELAEYQWTTPDNGYTRNFSSAMAMQVPGPECKDGVSPIEPPYTRQTTDVPLSINILTDGAARFVYHTSQYSRADIVRLGKYFQRALQLLLRPHRPIEECLQGLLGCVDLQTLMGFGNCSSSLTTTVAIKEDLVTLFESAVSRNPMDVAVQKGNCHLTYQELDTHAGRVAATLRGYIQDGDVVCLHADRSVNWIVGIMGILKAGGVYCALDKALPQEARETIFSASGSRLFLVPSLSDQSFCPTDCDRLLVVEDLVKDDNVPITHRDSPRPQTDAYLCFTSGSTGKPKGVMCLHQGLVAFQRDLEVRLFAQPGRRVAQIMSVAFDGSIHEIFSALSYGAALVLQSGDDPFAHLSDVDSAILTPSMARVLNPADFERLSTVSTKVYLVGEPVTQDVCDRWSEQKTLYNMYGPTEGTCGATIKQLHPRQRVTIGPPNPSTRIYIMNQHQELVPPGVIGEIYIAGVQVARHYIGMPEQTAQRFVADPIIRIGERMYKTGDRGYWSEDGEVVCLGRTDRQIKLRGFRLDLDDLETRMIRAFPAVTAVALTRQGNHLIAAILPASTDVDAFSARVAQVLPPYATPRKILALDEFPTTKAGKRDYLAIAKLSAQAPVSTGRTLTSPMEKLVGDAFRDILQLGKDVALHTHSSFRELGGHSLLQLLLATRISQGVNRQVPLYVVAQHDRIDHLAAAIDSGLGLQQLVTTDPMGLGESAIAPIEREWWHKYQINESTSSFNVNFMAKIDDCLVDRARLVHACNEVMARHRVLRSRYIFSRAAGRVVRQYSPLAPRVQAVKTVNPWVEVNRPFSLSRSAPIRAVVSDSYFILTISHIVADLTTLQILLREISSHYQGGSLPSIPHTYMNSTLWYEKPTSCDLDFWSDCLGQLPDTTHLLGHGGYRRGYRGRSALCEVPPTTYQSMRHFLRQSSITAQQLSLATIALCLDDPSVPMPTETDIVLGIPYINRKSQEDLDVVGLFLEPLPVRISFGQETHNHEKASYLDTVQRSVRSSVGHAVHWDQLLEHLQVSTTPPDHPLFDVVVTFHSQSHSNGLELSAPGLRTCYTYAEGAKFRLLCEFSALSEDRLLLRLEYDTDCFTEENIQLLQARIPLALSLLVQNVPYDMIRQTLACPPETQPVKVLKPDVVFGTPLSDI
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells (PubMed:25302411).  The non-ribosomal peptide synthetase (NRPS) aclP is responsible the formation of the diketopiperazine (DKP) core from the condensation of 2 phenylalanine residues (PubMed:25302411).  One Phe residue is tailored into chlorotyrosine by hydroxylation and chlorination, whereas the second Phe undergoes an unprecedented C-C bond cleavage to be converted into glycine (PubMed:25302411).  After formation of the DKP, sulfur is incorporated into the DKP by conjugation with glutathione by aclG, followed by its stepwise degradation to the thiol by aclI, aclJ and aclK, and the dithiol oxidation by aclT (PubMed:25302411).  In addition, oxygenases (aclB, aclC, aclL and aclO) and O-methyltransferases (aclM and aclU) act as tailoring enzymes to produce the intermediate dechloroaspirochlorine (PubMed:25302411).  Ultimately, chlorination of dechloroaspirochlorine by the halogenase aclH is the last step in the aspirochlorine pathway (PubMed:25302411).
What are the official names of this protein?
Nonribosomal peptide synthetase aclP, NRPS aclP, Aspirochlorine biosynthesis protein P.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.