PharMolix/UniProtQA huggingface dataset:
Protein: RAC1_DROME
Sequence: MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDAKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWYPEVRHHCPSTPIILVGTKLDLRDDKNTIEKLRDKKLAPITYPQGLAMAKEIGAVKYLECSALTQKGLKTVFDEAIRSVLCPVLQPKSKRKCALL
What is the function of this protein?
During various developmental processes, regulates changes in cell morphology in response to extracellular signals (PubMed:7958857, PubMed:10323867, PubMed:24855950).  During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte.  Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE-cadherin (shg)-mediated adhesions.  In turn, DE-mediated adhesion between the leader border cells and nurse cells further promotes Rac1 signaling creating a positive feedback loop that amplifies the output of RTK activity and leads to higher Rac activity at the front, thus promoting polarization of the border cell cluster and directionally persistent migration (PubMed:24855950).  Involved in axon outgrowth and myoblast fusion (PubMed:7958857).  Plays a role in regulating dorsal closure during embryogenesis (PubMed:10323867).  Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S. aureus by hemocytes (PubMed:22547074).
What are the official names of this protein?
Ras-related protein Rac1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: THIED_CORGL
Sequence: MTDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCDARGVALVVNDYLDIAVELGLHLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQCAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAAVAQDHGIASVAIGGVGLRNAAELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPSAPRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCVVTSLVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVTVDAIKLGMLGSADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQGFARTHDTIVIVKGGHLTGALADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATKIAAGESVEKALEWSTRWLNEALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSPAPRIEPAGPFTRALWEASGDIIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSRALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMAGKEVSAPSHITMAYTDFLIARTYTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLEKALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS
What is the function of this protein?
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
What are the official names of this protein?
Thiamine biosynthesis multifunctional protein ThiED.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the thiaminase-2 family.
Protein: HIS7_BURM9
Sequence: MRVAQVVRNTSETQISVKIDLDGTGRQKLATGVPFLDHMLDQIARHGLVDLDIEAHGDTHIDDHHTVEDVGITLGQAVAKAVGDRKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAHHQLETVFKAFGRALRMAVELDERAAGQIPSTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRE1G_ORYSJ
Sequence: MDVSAALSSDYSSGTPSPVAADADDGSSAYMTVSSAPPKRRAGRTKFKETRHPVFKGVRRRNPGRWVCEVREPHGKQRIWLGTFETAEMAARAHDVAALALRGRAACLNFADSPRRLRVPPIGASHDDIRRAAAEAAEAFRPPPDESNAATEVAAAASGATNSNAEQFASHPYYEVMDDGLDLGMQGYLDMAQGMLIDPPPMAGDPAVGSGEDDNDGEVQLWSY
What is the function of this protein?
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'.  Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription (By similarity).
What are the official names of this protein?
Dehydration-responsive element-binding protein 1G, Protein DREB1G.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: THIM_SALDC
Sequence: MQPDLHCRTLAAHTLKHFRALSPLTHCMTNDVVQTFTANTLLALGASPAMVIDPVEARPFAAIANALLINVGTLTASRADAMRAAVESAYDAKTPWTLDPVAVGALEFRRRFCLDLLSLRPAAIRGNASEILALSGMALGGRGVDTTEAALAALPAAQALARQIDCIVVVTGEIDYVTNGQRTLSIPGGDPLMTRIVGTGCALSAVVAASCALPGAALDNVASACCWMKLAGQAAAERSEGPGSFIPAFLDALYHLDVEAANATN
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: UCP1_MOUSE
Sequence: MVNPTTSEVQPTMGVKIFSAGVSACLADIITFPLDTAKVRLQIQGEGQASSTIRYKGVLGTITTLAKTEGLPKLYSGLPAGIQRQISFASLRIGLYDSVQEYFSSGRETPASLGNKISAGLMTGGVAVFIGQPTEVVKVRMQAQSHLHGIKPRYTGTYNAYRVIATTESLSTLWKGTTPNLMRNVIINCTELVTYDLMKGALVNNKILADDVPCHLLSALVAGFCTTLLASPVDVVKTRFINSLPGQYPSVPSCAMSMYTKEGPTAFFKGFVASFLRLGSWNVIMFVCFEQLKKELMKSRQTVDCTT
What is the function of this protein?
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (PubMed:9139827, PubMed:19187776, PubMed:23063128, PubMed:27027295).  Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane.  However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs.  Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP (PubMed:23063128).  Regulates the production of reactive oxygen species/ROS by mitochondria (PubMed:20416274, PubMed:20466728).
What are the official names of this protein?
Mitochondrial brown fat uncoupling protein 1, UCP 1, Solute carrier family 25 member 7, Thermogenin.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PAU16_YEAST
Sequence: MVKLTSIAAGVAAIAAGVAAAPATTTLSPSDERVNLVELGVYVSDIRAHLAQYYLFQAAHPSETYPVEIAEAVFNYGDFTTMLTGIPAEQVTRVITGVPWYSTRLRPAISSALSKDGIYTIAN
What are the official names of this protein?
Seripauperin-16.
What is the protein family that this protein belongs to?
Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
Protein: OAT1_STAAN
Sequence: MNSIIELTDYYSSNNYAPLKLVISKGKGVKVWDTDGKQYIDCISGFSVANQGHCHPTIVKAMTEQASKLSIISRVLYSDNLGKWEEKICHLAKKDKVLSLNSGTEAVEAAIKIARKWGSEVKGITDGQVEIIAMNNNFHGRTLGSLSLSNHDAYKAGFHPLLQGTTTVDFGDIEQLTQAISPNTAAIILEPIQGEGGVNIPPKGYIQAVRQLCDKHQILMIADEIQVGLGRTGKWFAMEWEQVVPDIYILGKALGGGLYPVSAVLANNDVMRVLTPGTHGSTFGGNPLAIAISTAALDVLKDEQLVERSERLGSFLLKALLQLKHPSIKEIRGRGLFIGIELNTDAAPFVDQLIQRGILCKDTHRTIIRLSPPLVIDKEEIHQIVAAFQDVFKN
What is the function of this protein?
Catalyzes the interconversion of ornithine to glutamate semialdehyde.
What are the official names of this protein?
Ornithine aminotransferase 1, OAT 1, Ornithine--oxo-acid aminotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RH28_ORYSJ
Sequence: MDADFRFDPDGSDDDGAAASAAAGRRKPAQSPWEFSSYAESVAAEHARRRTTSIDEKISQALSGSRRGGKPSIPDGDSEGDEDDSEVEDDSEEDDKEVVEGEIDDEEDEVEESEDDDEGVEVSDEEVEELEEGKGEEKSDEVEEGEEGQDGEEEEKEEGDEEAAEEEEETDKKSGVVDPSKFFASSEGASFHANSFLELNLSRPLLRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPAIRVLILTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSVGLEDLAILILDEADRLLELGFSAEIQELIRMCPRRRQTMLFSATMTEEINELVTLSLNKPVRLEADPSLKRPATLTEEVVRIRRAREANQEAVLLALCLKTFKDKVIIFSGTKHSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFKKQEVDFLIATDVAARGIDIVGVRTVINFSCPRDARTYLHRVGRTARAGREGYAVTFVTDDDRSLLKAIAKKAGSQLKSRIVAEKPVAECAKLIEELEDQISTIIQEEREERILRKAEMEATKAENMIAHKDEIYSRPKRTWFATEKEKKLLAKAAKESTSQGKSNSGVISAQQAEDLRLKEKKRREREKNLPRKKRRRLEAEREMLEDESEDEEEAKESKGGKKEKKGQSLVDVAYRRAKSMKASGKRGAGTGKGKNDKKAKQHSGKGPTRQEEMQELFQNDMSEWKQGRSLKKNNVMRKKSKNSFKSKSRYNRRK
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
Protein: NDK_RHORT
Sequence: MAIERTLSIIKPDATRRNLTGAINARFEEAGLRIVGQKRLRLTTAQAEGFYEVHKERSFFGSLVEFMTSGPVVVQVLEGENAVLKNREVMGATNPANAAEHTIRKDFAESIEANSVHGSDSAENAAHEIAYFFAQTEIVA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1317_BACAA
Sequence: MKLGIVIFPSKMIQDKANGLRKRYDPHYALVPPHITLKTPFETQDEQLESIVNKLHTIASKTNPFTLHVGKVGSFAPVNNVIYFKVEKTPELTFLNEEMHSGFFTQEREYAFVPHLTIGQGLSDAEHADVLGRLRMKDFYYEQPIDRFHLLYQLENGTWTVHETFRLGKGNN
What are the official names of this protein?
Putative phosphoesterase BAA_1317.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. YjcG family.
Protein: TRPB_PARL1
Sequence: MSVNKANSFRSGPDERGRFGIFGGRFVAETLMPLVLELDKAYAAAKADPAFQAEIDFMQRDYVGRPSPLYLAARLTEHFGGAKIYFKRDELNHTGSHKINNCLGQILLARRMGKTRIIAETGAGQHGVATATVCARFGLPCVIYMGTTDIERQKPNVFRMKLLGAEVVPVTSGTGTLKDAMNEALRDWVTNVENTYYLIGTVAGPHPYPAMVRDFQSVIGEETKKQMLEREGRLPDSLVACIGGGSNAMGLFHPFLDDPSVKIYGVEAAGHGLETGEHCASLKGGAPGVLHGNRTYLLQDDDGQIKDGHSISAGLDYPGIGPEHAWLHETGRAEYVSATDREALAAFQLCSKLEGIIPALEPAHALAFVTKIASALPKDHLMVMNMCGRGDKDVFAVADHLGVTL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RT13_ACACA
Sequence: MKKLQNFNTFVSDNKNKNIFSALKDIHGVNLKKINKMGLVMGLDKFEKVSSMNFELFSLIKKQAIFFYNLEENKIFNNVNKKKKIKNYTGMRHILKLPVRGQRTHTNAKTPSKNIKKEL
What is the function of this protein?
Located at the top of the head of the small subunit, it contacts several helices of the small subunit rRNA.
What are the official names of this protein?
Ribosomal protein S13, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYI_SHEON
Sequence: MSDYKFTLNLPETEFPMRGNLANREPEMLERWTKDGLYQQIRDSRIGRTPFILHDGPPYANGSIHIGHSVNKILKDIIVKSKTMSGFDAPYVPGWDCHGLPIELKVEQKVGKPGQKISAAEFREECRKYAAEQVDGQREDFIRLGVLGDWQNPYLTMDFATEANIVRSLSKVIENGHLHKGVKPVHWCTDCGSALAEAEVEYEDKTSPAIDVAFTAVDSKAVAVKFGVSDYSHSVSMVIWTTTPWTLPANRALSISPELDYSLVEFVKDGVTHAVILADVLVEACMTRYGAESHSVLAKIKGAALELVRFKHPFLAFDVPAILGDHVTTDAGTGVVHTAPGHGQDDFVVGQKYGLEVANPVGDNGVYKPDTEFFAGQHVFKANDNVVALLKEKGALLHHVAYRHSYPHCWRHKTPIIFRATPQWFISMDNHNLRKQALSEIEQIQWIPDWGQSRIEKMVENRPDWCISRQRTWGVPITLFVHRETEELHPDSVSLMARVANRIEQEGIQAWWDLDAAELLGEEAEQYRKVTDTLDVWYDSGSTFASVVAARPEFHGHGVDLYLEGSDQHRGWFMSSLMISTAMTGKAPYKQVLTHGFTVDGKGRKMSKSIGNVIAPQQVTNKLGADILRLWVAATDYSGEMTVSDEILNRSADAYRRIRNTARFLLANLNGFDPKNDLVAVEDMVALDRWAVRRAAALQQEIIEAYEQYNFHIVTQKLMQFCSIELGSFYLDIIKDRQYTAKQEGHARRSCQSALFHIAEAMVRWIAPVLSFTADEVWQLLPGQRDAYVFTQEWYQGLQSITLDTDLSDAYWENLLTVRNEVNKVIEQARRDKRVGGSLEAEVTLFADATLTEQLTHIGDELRFVLLTSEAKVLPLVDATSDAVETELASLKLVVNATTAEKCERCWHHREEVGTIEAHPTLCHRCVTNIEGDGEVRLFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_SYNFM
Sequence: MKHSVQVEVGGRPMVFEAGEIARQAGGSVLMRYGDTVVLIAATKEDRIREGIDFVPLMVDYQEMSYAAGRIPGGFFRREIGRPSEKETLTSRLIDRPIRPLFPKKYCYETQVVATVLSVDMENEPDVVALTGASTALHISPVPFQGPVAAVRVGRINGSFAINPSAKELLESDLNVVVAGSRDAVVMVEGGADFVSEDDLVDAIDFGHKAILPILDAQDELQRRIAPVKEAPPEVVRNESLVQAVRDAAAAEMRAVMTTPEKHPRRDRKKALKERIQAELVSDDPDRPKQIDNILEDLEKEVVRRMMVEEGRRIDGRRFDEIRPINIQAGVLPRTHGSAVFTRGETQVLAVVTLGSSSDEQKIEALAGETFKSFMLHYNFPAFSVGEVRPLRGPGRREIGHGALAERSVKAVLPRDGEFPYTIRVVSEVLESNGSSSMATVCGSSLALMDAGVPITEPVGGIAMGLVKEGDKIIVLSDILGDEDHLGDMDFKVTGSERGITAIQMDVKIAGIDRGIMQRALEQARAGRIFILGKMKEVLSAPRPELSPYAPRVITIMINPEKIRDVIGPGGKVIRSIVAETGAKIDIEDSGKVVIMSPDGAACDKAVERIRGLTQEPEVGQLYMSRIVRVTDFGAFAEILPNIEGLIHISQLEHRRVRKVTDVVQEGDEVLVKVIEIDKDGRIRLSRKAALEKPEGGGQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T1F_PARTE
Sequence: MFKVAVCALLVLASTAINVQSSIWTSKDQKAFAQIHQSGWGKFILNFAELHLTTGGILSELNSEIEKLIGEMEEELAGVHHEFNRRTDVHNREVARLEQEIQDKERELFNAHDFYDNVLIPQGERFAAQLEQLQENIAHNRQTLEQATVQRANDHETFESEVVEHNDAISAIDECLQLLSTIAAPSLAEVKKVQKNLAKIQNSLKKHNQFQIFVKVLLEITVDSNFADQGALRDIIVAFNNLRVELVDSLNQITADEAEQVADYNAQVIALNQEHAEFQRAVVVKNAEIEANTTKQEQTLDLIDELDEDLATLNGQLQAENDDYAFATDVYNATVAEYNKEINAANQALDLLNQPRFQDYVKSQLKGA
What is the function of this protein?
Structural protein that crystallize inside the trichocyst matrix.
What are the official names of this protein?
Trichocyst matrix protein T1-F, Secretory granule protein T1-F, TMP 1-F.
What is the protein family that this protein belongs to?
Belongs to the TMP family.
What are the subcellular locations of this protein?
Trichocyst. Note=These are architecturally complex secretory storage granules-docked at the plasma membrane, ready to rapidly respond to an exocytotic stimulus.
Protein: PDXH_FLAJ1
Sequence: MNDLSNYRKSYEKSELLETNIPEDPINLFNRWFHEVEDFGGSGEVNAMTVSTIGLDGFPKSRVVLLKKFSEEGFIFYTNYNSEKGKAIEANPNVCLSFFWQEAERQVIIKGIAQKTSEIISDNYFDSRPDGSKLGAIVSHQSEVIPSRTFLEENLKKLEAEFEGKPIPRPENWGGYLVTPLQVEFWQGRPNRLHDRIRYTSQSDFSWTIERLSS
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: GLR2_CAEEL
Sequence: MNKNLLVFGFLIFVKIGETSKKFPLRAFVASTDIDNDTAHAIIEMLRLAEMTFNALSDVDFDVLLGTRDLPPMEMATMMWNLNRIICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLIDWEPSKSENIGKTTENNPMIFSVAPSAEQLLIDYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSPKYQLFVDNYVAPSDEEMFKEFLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRALEESVLVKKEYHYVFSNFDVDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYRGGFSNTDSIPTAAAFAHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGRKGLYCRPHEDQTESRQFETFEHGKKIAEAIKKVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGVNSLNSIWERFQWAEGEGFLLGGERYVQEKKKDSSQTRKGILPSKPWQLRFNVVTVLVKPFVMLKRRNPGEPELKGNDRFEGYCIDLLNLLAKNITGFEYDVFISDGNKYGSRQADGSWDGMIGYLLNETADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGVSLTIFLVSWFSPYEKRIEFKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTANLAAFLTLERMTPPIESVEDLANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYADGIEKVRTSKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKGELKKLENKWWYDRGQCDTGTSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLFRKNKENREKERNRMRSSRPLKPGILASCERAKQKQLQNRRTKSEEVSTPRSTLF
What is the function of this protein?
L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.  The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists.  Required for response to mechanical and osmotic stimuli.
What are the official names of this protein?
Glutamate receptor 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi- pass membrane protein.
Protein: GREA_SULNB
Sequence: MQKEPMLEETYRKLSEELEQLKSVERGVIAKVIDEARELGDLKENAEYHAAKDKQGLMEARIAELTDVVGRAQVVDPSTFSHDRVSFGSTVVLVDQDTDEEVRYTIVGGQESNPQSGLISIQSPMARVLIGKEEGDEVELTLPSGKKTYDIEEILYEEITLG
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: DDX42_MOUSE
Sequence: MNWNKGGPGTKRGFGFGGFAISAGKKEEAKLPQQSHSAFGAASSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPADSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPSKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELASNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENSDRGNNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGTSSAGASGWTSAGSLNSVPTNSAQQGHNSPDNPMTSSTKNIPGFNNSGNISSAPVTYPSIGAQGVNNTASGNNSREGIGGGNGKRERYTENRGGSRHSHGDGGNRHGDGGRHGDGYRYPESGSRHTDGHRHGETRHGGSAGRHGESRGANDGRNGESRKEGFNRENKMDPKVDSSRMDKVDSKTDKTPDGFAVPEPPKRKKSRWDS
What is the function of this protein?
ATP-dependent RNA helicase.  Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures.  Unwinding is promoted in the presence of single-strand binding proteins.  Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein.  ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands.  Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2.  Relocalizes TP53BP2 to the cytoplasm.
What are the official names of this protein?
ATP-dependent RNA helicase DDX42, DEAD box protein 42.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX42 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CYOE_ECOLI
Sequence: MMFKQYLQVTKPGIIFGNLISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLISPAVSLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGEFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLSLGGYAGYKYLVVAAAVSVWWLGMALRGYKVADDRIWARKLFGFSIIAITALSVMMSVDFMVPDSHTLLAAVW
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ADE_AGRFC
Sequence: MTSHLLKAEIHCHLEGAAPPALVVKQAEKYGIDTSGFLRDGQYVWSDFAEFIQCYDAVAQVFKSDEDYAVLTETYLTELAEANTIYSELIISPDHGDRIGLGADAYLAGVAEGIRIAKEKTGIETRIIVTGERHFGPERVIAAAEYAARIRHPLVTGFNMAGEERMGRVADYARAFDIARDAGLGLTIHAGEVCGPESVADALDLVKPSRIGHGVRAIEDAALISRLVETGTVLEVCPGSNIALSVYPDFASHPLKALSDAGVRVCISSDDPPFFFTSLAREYALAADAFGFNDAEINRMTRTALECAFVDEATRERLLARLGDA
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenine to hypoxanthine.  Plays an important role in the purine salvage pathway and in nitrogen catabolism.
What are the official names of this protein?
Adenine deaminase, ADE, Adenine aminohydrolase, AAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Protein: CH10_GEOMG
Sequence: MKLRPLQDRILVKRIEEEQVTAGGIFIPDTAKEKPQRGEIVAVGNGKKTEDGKVIPIDLKVGDKVLFGKYAGTDIKVEGEDFLIMREDDILGVIE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_PAROL
Sequence: MAPTKKGEKKKGRSAINEVVTREYTINVHKRIHGVGFKKRAPRAIKEIRKFAVKEMGTPDVRIDTRLNKAVWSKGVRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTCKGLQTVNVDEN
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YMGG_ECOHS
Sequence: MKKKILAFGLISALFCSTPAMADMNRTTKGALLGAGVGLLTGNGVNGVLKGAAVGAGVGAVTEKGRDGKNARKGAKVGAAVGAVTGVLTGNGLEGAIKGAVIGGTGGAILGKMK
What are the official names of this protein?
UPF0757 protein YmgG.
What is the protein family that this protein belongs to?
Belongs to the UPF0757 family.
Protein: RL17_PHYAS
Sequence: MPFSKLGRNKSQRRALLRTLMTDLIVNEQIITTESKAKELQRLADKMITLAKKGTLHTRRQAARHLFDEKINEETTVLQKLFQKLASQYLNCQGGYTRVIKTVPRRGDAAPMAIIAFA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.