PharMolix/UniProtQA huggingface dataset:
Protein: SYA_AZOSB
Sequence: MKSAEIRAKFLKFFESKGHQIVASSSLVPHEDPTLLFTNAGMNQFKDVFLGFDKRPYSRATTSQKCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAITYAWELLTEVFKLPKDKLWVTVYAEDDEAYDIWTKEVGVPAERVIRIGDNKGARYASDNFWMMGDTGPCGPCTEIFYDHGPHIWGGPPGSPEEDGDRYIEIWNNVFMQFNRDEQGVMHPLPKPSVDTGMGLERISAVLQGVHANYEIDLFKSLISSAMRAVGTAEALVERARDSMTNTISPSYKVLADHIRACSFLIADGVIPGNEGRGYVLRRIIRRAIRHGYKLGARAAFFHKMVPDLVAEMGEAYPELKAGERRVADVLRQEEERFFATIENGMAIVEGELAAMATAGNTVFNGDTAFKLHDTYGFPLDLTADICREREVTVDAAAFDAAMARQKEQARAAGKFKMAANLDYDGPATTFHGYDKLEAKGNILALYKDGVAVNELVEGDLGVVVLDHTPFYAESGGQAGDRGELKGAAGIFGVEDTLKIQASVFGHHGVVKTGKLAVGQGVAARVDTAARAATARNHSVTHLMHKALREVLGPHVQQKGSLVDPDKTRFDFAHTAPMSAEEIREVEEIVNREILANAATEAAVMALDDAQKSGAMMLFGEKYGDEVRVLSIGSSKELCGGTHVARTGDIGLFKIVVEGGVAAGVRRVEAVTGENALRYTQEQERRVQGVSALLKVQPDEVAERVAGILDNVRALEKELARLKSKLAASQGEDLVAQAVDVGGAKLLAATLEGADVPTLRETMDKLKDKLKSAAIVLASVADGKVSLIAGVTADLTGKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPDKLPAALAAVQAWVSAKL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRI_NITMS
Sequence: MEQSELMVRRIKEGTVIDHIDEGKGIQVLNALRIDGSDGSLITIALNVPSGKFKKKDIIKVENKFLKDDDTNKLAVIAPKATINMIKDYKLVEKRRVSLPNEIDRIFRCSNPDCVTNSTEHIESIMDVIDKEGRVLKCRYCSRVLDVNQLKYN
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: NICA_HUMAN
Sequence: MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
What is the function of this protein?
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874).  The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
What are the official names of this protein?
Nicastrin.
What is the protein family that this protein belongs to?
Belongs to the nicastrin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein: DNLI2_METAC
Sequence: MTSFREFAETCQAIEKISSTIETTNKVADLLKKVDVEELPLATHFIMSEVFPAWSGEQLGIGTSLLYSSLSKASGMSVRSIESLIRTTGDIGETALLILKEKRKNQVTFSSFLEEQPELSITEVYQRFKTASEASGKGSQELKIKNLQFLFNSSTPREAKYISRLALEELRIGVGEGVVRDAIARAFSVPSDKVEHAFMVTNDLGIVAAAAKEGGIEALESLGIEINRPIKMMLSQISPDIDADIRDMKGAAIEWKFDGARVQIHKNGNSVTLFSRKLENVTNSLPDLVEIIRKHVKAESAILDGEAVAVDENGKPRAFQEILKRFRRKYDVEEKALGIPIQLNLFDIMYLNGRTLIDLPLVERRKALESCVESSVEDSKSISVDEQVITGDLELVEKIYREALNAGHEGVMVKNPNSAYSPGKRGKNWLKKKPLMETLDLVVVGAEWGYGRRANLIGSYSVACYDPETSRFLQVGKVGTGLTDEQLKELTEMLSGLMEGGEAGGVFAIRPKVVLEIAFEEIQKSPNYDSGFALRFPRFIRIRDDKDPEEADTIQRIGRVYSQQLKRL
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase 2, Polydeoxyribonucleotide synthase [ATP] 2.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: RIMP_MYCBO
Sequence: MTTGLPSQRQVIELLGADFACAGYEIEDVVIDARARPPRIAVIADGDAPLDLDTIAALSRRASALLDGLDGANKIRGRYLLEVSSPGVERPLTSEKHFRRARGRKVELVLSDGSRLTGRVGEMRAGTVALVIREDRGWAVREIPLAEIVKAVVQVEFSPPAPAELELAQSSEMGLARGTEAGA
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP7_ROTHW
Sequence: MYGIEYTTILIFLISIILLNYILKSVTRIMDYIIYRFLLITVALFALTRAQNYGLNLPITGSMDAVYTNSTQEEVFLTSTLCLYYPTEASTQINDGDWKDSLSQMFLTKGWPTGSVYFKEYSNIVDFSVDPQLYCDYNLVLMKYDQSLELDMSELADLILNEWLCNPMDVTLYYYQQSGESNKWISMGSSCTVKVCPLNTQTLGIGCQTTNVDSFEMIAENEKLAIVDVVDGINHKINLTTTTCTIRNCKKLGPRENVAVIQVGGSNVLDITADPTTNPQTERMMRVNWKKWWQVFYTIVDYINQIVQVMSKRSRSLNSAAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER. cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: DHSL_CYAP4
Sequence: MSQLFSHKIAPSPIPDNISVVDLIDNYFTAYNSARLREICHLLAQKVMQPGVTVGLSLSGAMTPTGLGISALAPLVRAGLIDYIISTGANLYHDLHYALGMDLYASHPFVDDVKLRQESRIRIYDIIFDYDVLLETDAFIREVLRAEPFQRRMGTAEFHHLLGQYARAAEVELGRSHSSLLATAYECGVPIYTSSPGDSSIGMNVAALALEGSQLVLDPALDVNETAAIAYFARESDIPDQEGKSAALIIGGGSPKNFLLQTQPQIHEVLGLEERGHDYFIQITDARPDTGGLSGAVPSEAVSWGKVDPNGLRDTVVCYTDSTIALPILTAYVLNQCAPRPLKRLYDRRPAMIEELQRLYLQAQFKQQAEAKLGKEQMPEPQSTEPVATYPCGTPIKGRK
What are the official names of this protein?
Deoxyhypusine synthase-like protein.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: RECR_HELP2
Sequence: MNTYKNSLNHFLNLVDCLEKIPNVGKKSAFKMAYHLGLENPYLALKITHALENALENLKTCSSCNALSESEVCEICSDESRQNSQLCMVLHPRDVFILEDLKDFLGRYYVLNSIEEVDFNALEKRLIEENIKEIIFAFPPTLANDSLMLYIEDKLQHFHLTFTKIAQGVPTGVNFENIDSVSLSRAFNSRIKA
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: PXG4_ARATH
Sequence: MASSISTGVKFVPEEDNFLQRHVAFFDRNKDGIVYPSETFQGFRAIGCGYLLSAVASVFINIGLSSKTRPGKGFSIWFPIEVKNIHLAKHGSDSGVYDKDGRFVASKFEEIFTKHAHTHRDALTNEELKQLLKANKEPNDRKGWLAGYTEWKVLHYLCKDKNGLLHKDTVRAAYDGSLFEKLEKQRSSKTSKKHP
What is the function of this protein?
Calcium-binding peroxygenase involved in the degradation of storage lipid in oil bodies.  May be involved in the interaction between oil bodies and vacuoles during seed germination (By similarity).  Acts as a negative regulator of abscisic acid responses in non-seed tissues.
What are the official names of this protein?
Probable peroxygenase 4, AtPXG4, Caleosin-4.
What is the protein family that this protein belongs to?
Belongs to the caleosin family.
What are the subcellular locations of this protein?
Lipid droplet.
Protein: TSHB_CHICK
Sequence: MSPFFMMSLLFGLTFGQTASVCAPSEYTIHVEKRECAYCLAINTTICAGFCMTRDSNGKKLLLKSALSQNVCTYKEMFYQTALIPGCPHHTIPYYSYPVAISCKCGKCNTDYSDCVHEKVRTNYCTKPQKLCNM
What is the function of this protein?
Indispensable for the control of thyroid structure and metabolism.
What are the official names of this protein?
Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, TSH-B, TSH-beta, Thyrotropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: YL283_MIMIV
Sequence: MEFTEQLFMITGCPERHNDKPIGRGFNIISMKSFKKGKGFILFEAKHIPKNYYGYYLRPVILPTNNREFAFQKSPWGYYTNMVSLDEIYELANPQTFYMLEKYGLDLGEMSAESRALNYSKYYADDYTNSFAHKYFLSRKNMYEDGHCQDIDCEPNQSEDTDCESNRSENSEDIGYVIDFNNIYKLKNVTHTPYLGMNLPDRLFIITVYRGVFGTKLISQGLNCFSKQEFNRQKGFIVLNAKNIIKDCYGYFIHSVILPTSHPEFILEDRHTYYYTNMVIIDKTYELSDPETFRILGKYGLDLTVYSAEQRAKNYETSRPMNVLKSTSNHHMPSCDFSHVDSTYNRTSTTSVWTTKNIPLTIDTKVNNIHQFIQKDEFKSAQKLLEDDIVFKKVVDTAIKSNNQKTIKYLIDQQQFDINEAIKLALEENKLDIFNMLRLFNFDKVRCLATASILGYLEIVDKMMENDFEKINGDLVNIVLRNAAEGGKIDIVWYISEKFIEFVTKIDIEVAETIVKQRIQHICTFSDDNDIDISVEQDMLELFENMKMIVVNSKF
What are the official names of this protein?
Putative ankyrin repeat protein L283.
Protein: MOBA_XANC5
Sequence: MTLQRPWTGVVLAGGRSSRMGQDKALLPWHGRPLLEQMQALLRQAGAQHVVVSGNRPEYAGIADVHPDLGPLGGLASVIANAADATTLVVVPVDMPLLSAALLGKLLAPSQHRCVAFEDQMLPMCLRLDASVREALTVLMAGAASSRSLRALQHSLQCHRVTVTASERAEFVNCNTPEQWSRLIHENPD
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMO41_XENTR
Sequence: MVNNRVTESTTTAVSSNGGPPKACAGCGGKIADRFLLYSMERYWHTRCLKCSCCQAQLGEIGTSCYTKSGMILCRNDYIRLFGSSGACSACGQSIPASEMVMRAQGSVYHLKCFTCATCRNRLVPGDRFHYVNGAIFCEHDRPTGLLSGHLNPLQSNPPMLPDQKVC
What is the function of this protein?
Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation.  Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors.  At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity).
What are the official names of this protein?
LIM domain transcription factor LMO4.1, LIM domain only protein 4.1, LMO-4.1.
Protein: YIBD_ECOLI
Sequence: MMNSTNKLSVIIPLYNAGDDFRTCMESLITQTWTALEIIIINDGSTDNSVEIAKYYAENYPHVRLLHQANAGASVARNRGIEVATGKYVAFVDADDEVYPTMYETLMTMALEDDLDVAQCNADWCFRETGETWQSIPTDRLRSTGVLTGPDWLRMGLSSRRWTHVVWMGVYRRDVIVKNNIKFIAGLHHQDIVWTTEFMFNALRARYTEQSLYKYYLHNTSVSRLHRQGNKNLNYQRHYIKITRLLEKLNRNYADKIMIYPEFHQQITYEALRVCHAVRKEPDILTRQRMIAEIFTSGMYKRLITNVRSVKVGYQALLWSFRLWQWRDKTRSHHRITRSAFNLR
What are the official names of this protein?
Uncharacterized glycosyltransferase YibD.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: SYK_BURVG
Sequence: MTEPTQTQPAVAADENQIIAERRDKLRALREQGVAYPNDFRPTHHAAELQSTYADSDKAALEANPVEVSVAGRMMLKRVMGKASFATVQDGSGQIQFFVTPNDVGAETYDAFKKWDLGDIVAARGVLFRTNKGELSVQCKELRLLAKALRPLPDKFHGLADQEMRYRQRYVDLIVTPETRDTFRARTKTISSIRRFMENADFMEVETPMLHPIPGGAAAKPFITHHNALDMQMFLRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTEQLIRQAAIDALGTATIQYQGRELDLAKPFHRLTITQAIQKYAPQYTDGQLSDDAFLRTELKRLGVDVSQPAFLNAGIGALQLALFEETAESQLWEPTYIIDYPVEVSPLARASDTVPGITERFELFMTGREIANGFSELNDPEDQAARFKKQVEQKDAGDEEAMFFDADYIRALEHGMPPTGGCGIGIDRLVMLLTDSPTIRDVLLFPHLRRED
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDK1_YEAST
Sequence: MSGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES
What is the function of this protein?
Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles (By similarity).  Required to drive the G1-S transition (PubMed:2664468).  More than 200 substrates have been identified (PubMed:14574415).  Substrate specificity is in part regulated by the bound cyclin protein (By similarity).  Phosphorylates YTA7 during S-phase to promote transcription of histones (PubMed:22156209).
What are the official names of this protein?
Cyclin-dependent kinase 1, CDK1, Cell division control protein 28, Cell division protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: SEC24_YEAST
Sequence: MSHHKKRVYPQAQLQYGQNATPLQQPAQFMPPQDPAAAGMSYGQMGMPPQGAVPSMGQQQFLTPAQEQLHQQIDQATTSMNDMHLHNVPLVDPNAYMQPQVPVQMGTPLQQQQQPMAAPAYGQPSAAMGQNMRPMNQLYPIDLLTELPPPITDLTLPPPPLVIPPERMLVPSELSNASPDYIRSTLNAVPKNSSLLKKSKLPFGLVIRPYQHLYDDIDPPPLNEDGLIVRCRRCRSYMNPFVTFIEQGRRWRCNFCRLANDVPMQMDQSDPNDPKSRYDRNEIKCAVMEYMAPKEYTLRQPPPATYCFLIDVSQSSIKSGLLATTINTLLQNLDSIPNHDERTRISILCVDNAIHYFKIPLDSENNEESADQINMMDIADLEEPFLPRPNSMVVSLKACRQNIETLLTKIPQIFQSNLITNFALGPALKSAYHLIGGVGGKIIVVSGTLPNLGIGKLQRRNESGVVNTSKETAQLLSCQDSFYKNFTIDCSKVQITVDLFLASEDYMDVASLSNLSRFTAGQTHFYPGFSGKNPNDIVKFSTEFAKHISMDFCMETVMRARGSTGLRMSRFYGHFFNRSSDLCAFSTMPRDQSYLFEVNVDESIMADYCYVQVAVLLSLNNSQRRIRIITLAMPTTESLAEVYASADQLAIASFYNSKAVEKALNSSLDDARVLINKSVQDILATYKKEIVVSNTAGGAPLRLCANLRMFPLLMHSLTKHMAFRSGIVPSDHRASALNNLESLPLKYLIKNIYPDVYSLHDMADEAGLPVQTEDGEATGTIVLPQPINATSSLFERYGLYLIDNGNELFLWMGGDAVPALVFDVFGTQDIFDIPIGKQEIPVVENSEFNQRVRNIINQLRNHDDVITYQSLYIVRGASLSEPVNHASAREVATLRLWASSTLVEDKILNNESYREFLQIMKARISK
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.  SEC24 specifically recruits cargo proteins like BET1 or SYS1 to the COPII vesicles.  The SEC23/24 complex is also involved in internalization of plasma membrane proteins like the maltose transporter.
What are the official names of this protein?
Protein transport protein SEC24, Abnormal nuclear morphology 1.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MEPS_ECOL6
Sequence: MVKSQPILRYILRGIPAIAVAVLLSACSANNTAKNMHPETRAVGSETSSLQASQDEFENLVRNVDVKSRIMDQYADWKGVRYRLGGSTKKGIDCSGFVQRTFREQFGLELPRSTYEQQEMGKSVSRSNLRTGDLVLFRAGSTGRHVGIYIGNNQFVHASTSSGVIISSMNEPYWKKRYNEARRVLSRS
What is the function of this protein?
A murein DD-endopeptidase with specificity for D-Ala-meso-diaminopimelic acid (mDAP) cross-links.  Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion.  Functionally redundant with MepM and MepH.  Also has weak LD-carboxypeptidase activity on L-mDAP-D-Ala peptide bonds (By similarity).
What are the official names of this protein?
Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase, Lipoprotein Spr, Murein hydrolase MepS.
What is the protein family that this protein belongs to?
Belongs to the peptidase C40 family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: MIA40_CRYNJ
Sequence: MFARSFSNASRTIARRSLSTRSGPAPSSLWSSRNAVIAGTTLAITALAVTSERRKVFNESAQKATSPRDSIIAQDSLKENVHKKSVRQDEFSGESTKPEASTSSDSVEKAADDAAQILEEKEAEASEPSQGAYNPETGEINWDCPCLGGMATGPCGEQFKAAFSCFVYSEAEPKGVDCVELFKVMQDCFREHPEIYGEVDTLGLVLMFYAEIDDDEAPAQEGTMEEKVEAAKEETAAPAAAP
What is the function of this protein?
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS).  Forms a redox cycle with ERV1 that involves a disulfide relay system.  Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.  The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
What are the official names of this protein?
Mitochondrial intermembrane space import and assembly protein 40, Mitochondrial import inner membrane translocase TIM40.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side.
Protein: TRA8_YEREN
Sequence: MPNVTLIGIDLGKNSFHIHCQEKHGNTLLRKRFSRIQLTQFLATCPPCIVAMESCAGAHFMARHISQLGHQVKLISPQFVRPFVKSNKNDFIDAEAICEATSRPSMHFVTPRTEDQQAMSALHRVRDALVRERVKATNQMHAFLLEFGISMPRGIAVIKRLATVPEEHELPPYLVRLLTRLHQHYGYLCEQIEEIERELKNHLADDETAQRLLTIPGIGTITASLLATKLGDGKNYLSSRDFGASTGLVPRQYSTGGKSTLMGISKRGDKNLRRLLVQCARVYMQRLEYQSGRLAEWVNGQLTRHHSNVVACALANKLARIAWVVTTQGTVFSK
What is the function of this protein?
Required for the transposition of the insertion element.
What are the official names of this protein?
Transposase for insertion sequence element IS1328.
What is the protein family that this protein belongs to?
Belongs to the transposase IS1111A/IS1328/IS1533 family.
Protein: DRS4_PHYSA
Sequence: ALWMTLLKKVLKAAAKALNAVLVGANA
What is the function of this protein?
Potent antimicrobial peptide with activity against bacteria and protozoa (By similarity).  Also has activity against fungi (PubMed:8306981).  Also shows activity against enveloped herpes simplex virus type 1 (PubMed:11782932).  Probably acts by disturbing membrane functions with its amphipathic structure (Probable).  Binds to healthy erythrocytes (this binding is receptor independent), and has strong hemolytic activity (PubMed:9395500).  Does not bind to P. falciparum infected erythrocytes, but accumulates within the parasite (PubMed:9395500).  Kills the parasite, and only at high concentrations has a hemolytic activity on the host cell (PubMed:9395500).  In vitro, shows high spermicidal activities (PubMed:16307969).
What are the official names of this protein?
Dermaseptin-S4, DRS-S4, Dermaseptin IV, DS IV, Dermaseptin-4, DS4.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GLMM_RHIME
Sequence: MKRRYFGTDGIRGQSNIFPMTPDLAMRVGIAVGTIFRNGAHRHRVVIGKDTRLSGYMLENAMVAGFTAAGLDVFLLGPIPTPGVAMLTRSLRADIGVMISASHNAFRDNGIKLFGPDGYKLSDDIEQKIEDLLEQDMSGQLAKPEDIGRAKRVDGDIYRYIEQAKRTLPRDVTLKGLRIAIDCANGAAYKVAPSALWELGAEVVTIGTEPNGVNINLECGSTHPAALQKKVHEVRADIGIALDGDADRVLIVDEEGAVIDGDQLMAVIADSWAADGMLKGGGIAATVMSNLGLERYLQARRLKLHRTKVGDRYVVEQMRQDGLNVGGEQSGHIVLSDFGTTGDGLVAALQILAVVKRQGKTVSEICRRFEPVPQVLKNVRVSAGKPLEDAAVQQAIAEAEAQLAKNGRLLIRPSGTEPLIRVMAEGDDRGQVERIVDELVNVIGGVRNAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RTCA_PSEAE
Sequence: MRKDLIELDGSEGGGQILRSALSLSMTSGQPLRIRNIRGRRSRPGLLRQHLTAVRAAAEICAAEVEGAELGSRELAFRPGAIRAGDYAFAIGSAGSCSLVLQTLLPALLAANGESRVRISGGTHNPLAPPADFLRDSWLPLLQRMGAEVDLELLRHGFVPAGGGELLARVRPARWRPLQLEHPGAALRRQARALLAGIPGHVGERELERVRQRLGWSDEERQLEFLAEDQGPGNALLLRIDCEHICATFCAFGQAGVSAERVAEQVATQAIGWMESGCAADEHLADQLLLPMALAGAGSFTTPRLSAHLQSNRRVIERFLPVRIGDQALDGGGHRIVITSA
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSB_ANASK
Sequence: MRHVAVIIPARYGASRFPGKPLADLAGKPLIAHVVERAKRARGVDVVAVATDDDRIARAVRDAGGEAILTGPAATGTDRVAEAARKLAPRPEIVVNLQGDEPLIEPEAIEAVIGAMEGGVRMATLARPLAAGELERTQVVKVVTRASGDALYFSRAPIPHRRAGGESPLARAHVGIYAFTAAFLETFTALAPGRLEGEEALEQLRALEHGYDIRVADTGYRGFGIDTPDDLERARALLAAGA
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGDA2_BACCR
Sequence: MEKALKIKQIVVVLIAIAAVAIGYYMFQSITSPAKAVAKQENVVQLASEQPKVEMNKTAPSRFNGKERKVAYLTFDDGPGKYTAELLNTLKQHDAKATFFLIGANVKEFPDLVKRENAEGHYVGMHSMTHNFAKLYKNGEYVNEMKEDQGLIANIIGKSPKLTRPPYGSMPGLNEGLRNKVVEGGFKVWDWTIDSLDWRYNKMPVDAAAAQIAQNVLTNATKPQEVILMHDIHPQSVAAVPAILKGLKEKGYEFEAYHEESHFPVNFWHDNRM
What is the function of this protein?
Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan.
What are the official names of this protein?
Peptidoglycan-N-acetylglucosamine deacetylase BC_1974, Peptidoglycan GlcNAc deacetylase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.