PharMolix/UniProtQA huggingface dataset:
Protein: ERCC2_HUMAN
Sequence: MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL
What is the function of this protein?
ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.  XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex.  Involved in the regulation of vitamin-D receptor activity.  As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation.  Might have a role in aging process and could play a causative role in the generation of skin cancers.
What are the official names of this protein?
General transcription and DNA repair factor IIH helicase subunit XPD, TFIIH subunit XPD, Basic transcription factor 2 80 kDa subunit, BTF2 p80, CXPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH 80 kDa subunit, TFIIH p80, Xeroderma pigmentosum group D-complementing protein.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD3/XPD subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle.
Protein: ACV1C_RAT
Sequence: MTPARRSALSLALLLVALASDLAAGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVSKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITQHLPTASPDAPRLGPTELTVVITVPVCLLSIAAMLTIWACQDRQCTYRKTKRHNVEEPLAEYSLVNAGKTLKDLIYDATASGSGSGPPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGLVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCKA
What is the function of this protein?
Serine/threonine protein kinase which forms a receptor complex on ligand binding.  The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases.  Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3.  Receptor for activin AB, activin B and NODAL.  Plays a role in cell differentiation, growth arrest and apoptosis.
What are the official names of this protein?
Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: TRH_BOMOR
Sequence: QHP
What is the function of this protein?
Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
What are the official names of this protein?
Thyrotropin-releasing hormone, TRH, Protirelin, TSH-releasing factor, Thyroliberin, Thyrotropin-releasing factor, TRF.
What is the protein family that this protein belongs to?
Belongs to the TRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: GATC_DROSE
Sequence: MLRLLSKRFYCKIATKSNEKATKLYFKQLTHPTKVPQTPVDAEFPDTSASEIQIDTKTIQLLERLSLVDLDSERALATLKSSIQFADKIAHINTDHVRPLYTVLEHQQLQLRNDQVTEGDCRAEVLQNAKVTDEDYYVSPPGNIPLEQ
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial, Glu-AdT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EFTU2_SHELP
Sequence: MAKEKFERSKPHVNVGTIGHVDHGKTTLTAAISHVLTKTYGGEAKDFAQIDNAPEERERGITINTSHIEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVASTDGPMPQTREHILLSRQVGVPFIIVFMNKCDMVDDEELLELVEMEVRELLSEYDFPGDDLPVIQGSALKALEGEPEWEAKILELAEALDSYIPEPERAIDGAFILPIEDVFSISGRGTVVTGRVERGIVKVGDEVEIVGIKETTKTTCTGVEMFRKLLDEGRAGENCGVLLRGTKRDEVERGQVLAQPGSITPHTQFESEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLICPIAMDEGLRFAIREGGRTVGAGVVAKIIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBP36_DROYA
Sequence: MPVSMAVCETANVVNAALRESLGGNSSAAGSSIDQAKSGEDSNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFGGKNNTGKVVGANGHDNNGARKQAEHPNNQSHHNNHNNHPHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLENCNVAESGGGCIVCAMAKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGNKLTKQISLKPRIDLSKYAARSPAAQAQPLTYRLVSMVTHLGVSQHCGHYTAIGSTDTGSYYNFDDSYVRPIAMQSVCNTNAYIMFYELDLSQAASPAANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPPGGVNGYSNGNAQKTAIQFKQHHQQSQQNGFQLGTGKFQDTAKPPLVGAHAKGDANPVPTANGNKSSSTSSNSSSNHKSINQQQYLPISSEDEDSEDEMTPRPTTAQLPSMPKMTDDHTEKPKSPVKIQVKTPVKTPLKSLVPYESASEEEEAPQPNPRKRRSEEDSSESDQESGQTNGHSKTNGSLTNGSASSSVHVNNSKQKTDAIDEIFKSLKKSADSDDDDDEEESSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKSKTGIWKVTRNDEVDDIDDDDDEEDEAPAKIQTPSKTHRNPFSSTKPSTESPATPGAKRQKLLNGSAVKSHQQPRVGNGYQSEATSNGSTINELLKQSHRGYGSSVLSWNGKPAELEKEPFELVCAKRIAGHGSVDGSDIVESSVAVNASSGSDSNDVVVIALLVDAREQRQRDLDDDEENEMDRGRQRKVKSSGSAKANNASNSTPGYNPFQEYEGQKRWNKNGGGGGGFPRFYNQNFRQNFQQRNKFKFNRFGGPGSAKFQQQRALQRHLAAGGGFSRRQPSAQQQQQQS
What is the function of this protein?
Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells.  May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4).  Controls selective autophagy activation by ubiquitinated proteins.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 36, Deubiquitinating enzyme 36, Protein scrawny, Ubiquitin thioesterase 36, Ubiquitin-specific-processing protease 36.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: YEBF_SALSV
Sequence: MNKRGALLSLLLLSASVSAFAASTESKSVKFPQCEGLDAAGIAASVKRDYQQNRIVRWADDQKKVGQADPVAWVNVQDVVGQNDKWTVPLTVRGKSADIHYQVIVDCKAGKAEYKPR
What are the official names of this protein?
Protein YebF.
What is the protein family that this protein belongs to?
Belongs to the YebF family.
What are the subcellular locations of this protein?
Secreted.
Protein: MUD2_YEAST
Sequence: MADEKRLEDLRSKIMESIGKSEKDVVPIENKRFNTDNAVIDTHFKRQKSDGELPKAPKSRNVSHSNNRGPSSIITMSTNRTTYEQTRAGPHRQSYRDASGRSYNRENRYSSHNTGPQWNNNPYNRQRDERRGRNERFDRRGRNGNGNYDRFNYQRKNEGSKFNGDRDKRQLQTNKYDMNYNSQNVMYPGSSFDSPAYYNMASSKANSRLVISGLSQSSDPSIVARLKDLLENFISGLQKTESNAEDFKISNFYIGEGRPDHIIVEFSSQICSTMVLACRSFFNAKLGTFDLKWRRPNDYVQQLDHLVDFCRGTVIALENLENIGEGEDYRMKELFSSLNVTNGTAKPLFYKCSSNTNNTGKESEFTKCILLSFEVVTQDILDKLKPYKWFKPNDGKISQVTSWITFQSLPNLVTQSVRVESRVLLLLNCLDPLDLKDETFITEIKETLKYSIAGADTIKICQPGVDYRLNFENLASGAGNIYIKFKTLEAAKHAMEELPGTQFNDRTVLCTYIDEDDFDMMEATQLS
What is the function of this protein?
Splicing factor that contacts pre-mRNA directly and is a component of the pre-mRNA-U1 snRNP complex (commitment complex 2) that forms during early spliceosome assembly in yeast extracts.
What are the official names of this protein?
Splicing factor MUD2.
Protein: ATPL_SHEPW
Sequence: METVLGMTAIAVALLIGMGALGTAIGFGLLGGKFLEGAARQPEMAPMLQVKMFIVAGLLDAVTMIGVGIALFMLFTNPLGAML
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS15_RICB8
Sequence: MSITQERKQELIKNYAINDNDTGSSAVQCAILTERINNLTEHFKSNHKDHTSRRGLLILVGRRRRLLNYIKKKNVSEYLDLISKLGIRKIK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: INUE_ASPAW
Sequence: MAPLSKALSVFMLMGITYAFNYDQPYRGQYHFSPQKNWMNDPNGLLYHNGTYHLFFQYNPGGIEWGNISWGHAISEDLTHWEEKPVALLARGFGSDVTEMYFSGSAVADVNNTSGFGKDGKTPLVAMYTSYYPVAQTLPSGQTVQEDQQSQSIAYSLDDGLTWTTYDAANPVIPNPPSPYEAEYQNFRDPFVFWHDESQKWVVVTSIAELHKLAIYTSDNLKDWKLVSEFGPYNAQGGVWECPGLVKLPLDSGNSTKWVITSGLNPGGPPGTVGSGTQYFVGEFDGTTFTPDADTVYPGNSTANWMDWGPDFYAAAGYNGLSLNDHVHIGWMNNWQYGANIPTYPWRSAMAIPRHMALKTIGSKATLVQQPQEAWSSISNKRPIYSRTFKTLSEGSTNTTTTGETFKVDLSFSAKSKASTFAIALRASANFTEQTLVGYDFAKQQIFLDRTHSGDVSFDETFASVYHGPLTPDSTGVVKLSIFVDRSSVEVFGGQGETTLTAQIFPSSDAVHARLASTGGTTEDVRADIYKIASTWN
What is the function of this protein?
Exo-inulinase involved in utilization of the plant storage polymer inulin, consisting of fructooligosaccharides with a degree of polymerization (DP) value from 2 to 60.  Splits off terminal fructose units successively from the non-reducing end of the inulin molecule, and also hydrolyzes levan, stachyose and raffinose.
What are the official names of this protein?
Extracellular exo-inulinase inuE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 32 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL34_DESHY
Sequence: MKRTYQPKNRRHKRVHGFLERMSSTSGRNVLKRRRLKGRKKLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PER1_CATRO
Sequence: LVCFVVVVFMAAAAAMAGADRELKYLSHGGVDFPVPAGRLDGVVSR
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RBFA_YERPP
Sequence: MAKEFSRSQRVSQEMQKEIALILQREIKDPRVGMATVSGIELSRDLAYAKVFVTFLNVLTDNADPDTVKNGIKALQDASGYIRTLLGKAMRLRIVPELTFAYDNSLIEGMRMSNLVSNVIKNDVERQVNPGSDEEK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_STAAS
Sequence: MIVIVDYGLGNISNVKRAIEHLGYEVVVSNTSKIIDQAETIILPGVGHFKDAMSEIKRLNLNAILAKNTDKKMIGICLGMQLMYEHSDEGDASGLGFIPGNISRIQTEYPVPHLGWNNLVSKHPMLNQDVYFVHSYQAPMSENVIAYAQYGADIPAIVQFNNYIGIQFHPEKSGTYGLQILRQAIQGGFIND
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_ORYSJ
Sequence: MELGLALRLVAPPPRLPCRALQPPPMPCFSPCAARRSRIRSSRLERRVGVVVSGGSMASLAMEEEEEEEWEEAEEEAEGWQEEEAAVVTTRPRLELIEKPDRSLCLLDEYESEELGTSHCANHRSGYVAVLGKPNVGKSTLINQIVGQKLSIVTDKPQTTRHRILGICSEPEYQIILYDTPGVIKKEMHKLDTMMMKNVRSAVGSADCVLVVVDACKMPEKIDEILEEGVGNKDTELPVLLVLNKKDLIKPGEIAKKLEWYQKFTNADDVIPISAKFGHGVDDIKEWILSKLPLGPAYYPKDIASEHPERFFVGEIVREKIFLQYRQEIPYACQVNVISYKSRPTAKDFIQVEILVEKESQRSIILGKDGKAIKMLATASRLDIEDFLQKKVYLEIMVKVKENWRQDELLLKRYGYGGEIQAL
What is the function of this protein?
Nuclear genome-encoded probable GTPase involved in ribosome biogenesis in chloroplasts.  Plays a role in 16S rRNA maturation in plastids and may contribute to the assembly of the small (30S) ribosomal subunit.
What are the official names of this protein?
GTPase ERA-like, chloroplastic, GTP-binding protein Era-like.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma, chloroplast nucleoid.
Protein: PYRE_SHEON
Sequence: MKAYQREFIEFALERQVLRFGEFTLKSGRISPYFFNAGLFNTGRDLARLGRFYAAALVDSGIDYDLLFGPAYKGIPIATTTAVALCEHHNIDIPYCFNRKEKKDHGEGGSLVGSELKGRVMLVDDVITAGTAIRESMEIIEAHQAQLAGVLIALDRQEKGKGELSAIQEVERDFGCGIVAIIKLADLISYLSEKPRMEAQLAAVSQYREQYGIEA
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: RUVB_RHOPS
Sequence: MTDPRLVTPERRGDDLGDAALRPQHLSEFVGQQQARANLQIFIDAARKRKEALDHVLFVGPPGLGKTTLAQIVARELGVGFRATSGPVIAKAGDLAALLTNLEERDVLFIDEIHRLSPAVEEVLYPAMEDFQLDLIIGEGPAARSVKIDLSKFTLVGATTRAGLLTNPLRDRFGIPVRLNFYTIEELESIVKRGARVLGTGITADGANEIARRARGTPRIAGRLLRRVRDFASAADADAIDRKIADHALGALEVDAAGLDAMDRRYLSTIALNYGGGPVGVETMAAALSEPRDAIEDIIEPYLIQCGYLQRTPRGRLLTASAFRHLGLAEPARDPGQFGLFGGEEDGD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ISPF_BACC2
Sequence: MFRIGQGFDVHEFAEGRPLIIGGITIPHEKGLIGHSDADVLLHTIADACLGAIAAGDIGKHFPDTDPAFKDADSAVLLQKVWEFVREQGYELGNLDCTIIAQKPKMAPHIESMRKRISELLETSIDNINVKATTTEKLGFTGREEGIASQAVVLLQKK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: SP153_IXORI
Sequence: MESFVAMKVVCIILLFVIAAEAESINEKSDVEPSKGKNNSGLQFKFPPYVPNHKAFALRLLSLCEQGIYGTKINDLKVDFKNCTFLCIRKYENLTLPLPEDTPCGPNNQTCHKKDECVGYIPGC
What is the function of this protein?
Salivary tick protein that downregulates host immune system by binding to both dendritic cells, and CD4(+) T cells.  Specifically binds to the CD4 coreceptor on T cells.  This interaction prevents the activation of the Src kinase, Lck, and its downstreamsubstrate Zap-70, and results in deficient activation of PLCgamma1, the repression of calcium fluxes triggered by T-cell antigen receptor (TCR) ligation, and a subsequent reduction in interleukin-2 production.  This salivary protein also binds to DC-SIGN (CD209) on dendritic cells (DC) and activates the Raf-1 kinase/MEK signaling pathway that results in down-regulating expression of pro-inflammatory cytokines.  Furthermore, it inhibits T cell proliferation induced by DCs (By similarity).  In addition, it inhibits in vitro keratinocyte inflammation induced by Borrelia burgdorferi or by the major outer surface protein (OspC) of Borrelia (By similarity).  In addition, it downregulates chemokines and monocyte chemoattractant protein 1, as well as several antimicrobial peptides such as defensins, cathelicidin, psoriasin, and RNase 7 (By similarity).  Apart from its immunomodulatory activities, it is also associated with protection of Borrelia spirochetes from antibody-mediated killing through its binding to OspC (By similarity) (PubMed:33401196).  In vivo, tests on different immune disease animal models show promising therapeutic results, e. g. , in inhibiting HIV infection, experimental autoimmune encephalomyelitis, transplantation rejection, and asthma (By similarity).
What are the official names of this protein?
Salivary protein 15 Iric-3, Salp15 Iric-3, Salp15-like.
What is the protein family that this protein belongs to?
Belongs to the salp15 family.
Protein: YIHI_YERPB
Sequence: MKQPNKAPRANIAAPKGTATPKRRRKTRDELDAEARDRKRQKKHSGNRSGARTNVEGSNKKGHSQTQEKDPRVGSKVPVPLVIESQVKAKSMPKPVEKNVVKPRLTPEEELAKLENDERLDALLDRLDNDEVLNKEDQAYVDLTLDRIDALMEQLGIELGDDEDDVEREEKQEDILQLLKRGNPKDTF
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: CAIE_SALNS
Sequence: MSYYAFEGLIPVVHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLILEAGSNLQDGCIMHGYCDTDTIVHENGHIGHGAILHGCVVGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFQGEARQLLVGSPARVLRQVTDQELHWKRLNTKEYQDLAIRCRTGLSETKPLTQVEENRPRLKGTTDVKPKSAQ
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: RSD_ENT38
Sequence: MLNQLESLTERVGGSNKLVDRWLHVRKQLLVAYYNLVGIKPGKESYMRLNEKALDNFCQSLVDYLSDGHFNIYERIIREMEGTNPYLAATKLYPQLEANTQQIMDYYDSTLENAIDQDNYLEFQQALSDLGEALEGRFTLEDKLIALALDNNLKASNEDNVARPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_PSEF5
Sequence: MKTGKELKPGTVIRIDNDPWLVQKAEFTKSGRNSAIMKTKLKNLLTGYKTETVYGADDKLDDVILDRKEATLSFISGDTYTFMDTTDYTMYELNAEDIEAVLPFIEEGMTDVCEAVFFEDRLVSVDLPTTIVRQVDYTEGSARGDTSGKVMKPAKLKNGTELSVADFIEIGDMIEIDTREGGSYKGRAKV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOEB_NEOYE
Sequence: MLNFKTENTKYSLEEYTRYSKHLVLPQIQLEGQERLKEAKVLFIGAGGLGSPGIIYLAAAGIGSIGIIDDDIIDLSNLQRQILYRCNDIGYSKVEIAKKKILDLNPQCIVTVFKTRLSYENSIDIIRQYDIIIDGSDNFDTRYLLNDTCLELNKIHIYGAIFQFEGQVSVFNYQGGPVYRDFYSETENKESARDTCSNSGVLGLLPGIVGTLQATEAVKIVLGYKSILSGTILTYNSLTSSFNKFKIINTKFVLSTKKHWNKYYGSKSSTFVREISVIQLQKFLISRNPQYILIDVRNHEEYHKSHLIHSLNLPLQKIKGMNYSHINLQDKICFVYCSLDSRSIFASKFLIAQKLNIVRVRGGLNAWKNIIGDLDWTL
What is the function of this protein?
Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD.
What are the official names of this protein?
Probable molybdopterin-synthase adenylyltransferase, MoaD protein adenylase, Molybdopterin-converting factor subunit 1 adenylase, Sulfur carrier protein MoaD adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the HesA/MoeB/ThiF family.
What are the subcellular locations of this protein?
Plastid, chloroplast.