PharMolix/UniProtQA huggingface dataset:
Protein: Y285_METS3
Sequence: MITLIGKDLAKKGNEFIFYGSVDECENCRFKASCVDSLEKNRKYKIIDVRDNEQKCPVHAENTVIPVEVDRSNITLLSSSKSIFEGSTFSYESADCDEECEYYDYCFPEGLVDGDKCIVLKNHGKHKGECKKGYKLNKLTLGFVI
What are the official names of this protein?
UPF0179 protein Msm_0285.
What is the protein family that this protein belongs to?
Belongs to the UPF0179 family.
Protein: EFTS_THEM4
Sequence: MISAKLVKELRDRTGAGMMECKKALEEANGDIEKAIEVLRKRGIAKAAKKASRETGEGIIASYVHFNKKIGVLVELNCETDFVARTEEFQELGNKIAMHVAAMSPRWVKREDVPQEVIEKEKEIYREQLKDSGKPEHVIEKIIEGKLNKFFEENCLYEQKFAFDEEKMVEDMIKEAIAKIGENIKVSRFVKFTVGE
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_METMA
Sequence: MTNSHGERRCTRYKLQKTVRERGISPVSKAIQEFEDGQMVHIDIDPSVQKGMPNPKFQGFTGKVIGQRGRSYILAVREGNSMKEVFSVPQHLKPQKY
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: KDSB_ALCBS
Sequence: MSFYVVVPARYASTRLPGKPLADIAGKTMVERVAQRCQQSDADQIYVATDDRRIADVLGDTVPVVMTREDHPSGTDRLQEVATKLALADDDIIVNVQGDEPLIPPAVINQVAANLAANPDCQMATLCEAIENSDDLFNPNVVKAVFDNRGKALYFSRAPVPWHRDAFADGQQDLSGGQWWRHIGIYAYRVAFLHQYVQWQPATLEKLESLEQLRAMANGVAIHVEPACEVVPGGVDTQTDLERLRAQLGGQ
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_BRUA2
Sequence: MADLAKIVEDLSALTVLEAAELSKLLEEKWGVSAAAPVAVAAAGGAAPAAAAEEKTEFDVVLADGGANKINVIKEVRALTGLGLKEAKDLVEGAPKAVKEGASKDEAEKIKAQLEAAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: DCA12_BOVIN
Sequence: MARKAVSRKRKAPALPGAGSDAQDPQFGWDHSLHKRKRLPPVKRSLVYYLKNREVRLQNETSYSRVLHGYAAQQLPSLLKEREFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTSQITKIPILKDREPGCVTQQGCGIHAIELNPSRTLLATGGDNPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWISDTMAVSGSRDGSMGLWEVTDDVLTKSDARHNVSRVPVYSHITHKALKDIPKEDTNPDNCKVRALAFNNKNKELGAVSLDGYFHLWKTENTLSKLLSTKLPYCRENVCLAYGNEWSVYAVGSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYEHIITVGTGQGSLLFYDIRAQRFLEEKLSACYGSKPKLAGENLKLTTGKGWLNHDETWRNYFSDIDFFPNAVYTHCYDSSGTKLFVAGGPLPSGLHGNYAGLWS
What is the function of this protein?
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity).  The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation.  Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy (By similarity).  Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation.  Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation (By similarity).
What are the official names of this protein?
DDB1- and CUL4-associated factor 12, WD repeat-containing protein 40A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DCAF12 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: HISZ_PSYCK
Sequence: MLPDGVVDVLFEDAHKQEVLRHQLIQQLISHGYQLVNPPMIEFTESLLSGASEDLKRQTFKIIDQLTGRLMGIRADITPQILRIDAHHGGDGIARYCYAGDVIHTLPSGLFGSRTPLQLGAEIFGCEYIAADIELIDVLFSMLNSLEMSAALHVDLGHVAIFKRLAELAVLSESDTEQLMQLYANKNLPELKQVCQALPLGSDFYTLARFGHDIANLLGRLSENAQQDAQIVTAIDELQRLKAHLQVQWQCAVSIDVTELSGYHYHTGIVFNGYINSETQPLVRGGRFDGMKSNQLATNQPRQATGFSMDVSRLLAHTQLDAPVIVLVDYDAFKDLGSEQLQLLLQQVASLRQQGYRVTMPLTAKDIPVGMTHRLSLVDNQWQLHAV
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_LISMC
Sequence: MDERIISSETVDAEEVSFETSLRPQNLSQYIGQDKVKNNLTVFIEAATLRNEALDHVLLYGPPGLGKTTLAMVIAAEMGSQIKTTSGPAIERPGDLATILTSLEPGDVLFIDEIHRLSRAIEEILYPAMEDYCLDIVIGTGPTARSVRLDLPPFTLIGATTRAGLLSAPLRDRFGVIDHLEFYTEEQLTEIVLRTSNILDTKIDDLGAREIARRSRGTPRIANRLLKRVRDFAQVRGNGTVTEKLAKEALTLLQVDPRGLDTIDQKLLHTIIQSFRGGPVGLDTIAASIGEERETIEDMQEPYLLQIGFLQRTPRGRIATETAYNHLGISYEKEV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PYRE_BUCAI
Sequence: MDWKKEFIDFSFKKKVLKFGVFQLKSGRISPYFFNSGLLSTGIDIIKIGLFYARSIIDSKNKFDVLFGPAYKGIPIAVATSIALKNHYNLNVPYSFNRKEYKEHGEKGDLIGSTIYKKRVIILDDVITSGTAIHHSIKIIEKQEASISSIFVLLDRKEKGIRKLSTINHFRNQKSYKIISIITIDDLIEYVLEDKKLKEHIPQLIKYREKYGI
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: CYC18_CLITE
Sequence: GLPICGETCFTGTCYTPGCTCSYPVCKKN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cliotide T18, Cyclotide cT18.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: HSPQ_ECOK1
Sequence: MIASKFGIGQQVRHSLLGYLGVVVDIDPVYSLSEPSPDELAVNDELRAAPWYHVVMEDDNGLPVHTYLAEAQLSSELQDEHPEQPSMDELAQTIRKQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBE_SYNS3
Sequence: MAAGSTGERPFFEIITSIRYWVIHAITLPSIFLAGFLFVSTGLAYDAFGTPRPDAYFQASESKAPVVSQRYEGKSELDLRLK
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: NODA_AZOC5
Sequence: MMVHNYCAPENVTAPPHVSRVTQYNKRGIRMISKVTWRVAWESDLTNGDHAELSDFFKSVYGATGAFNALPFAGGRSWAGARPELRGIAYDESGVAAHMGVLRRFIKVGGEQIAVAELGLYGVRRDLEGLGIGHSTLAMLPVLKALGVPFAFGCFRNELRIHFQRFCRNGKGAIVDNVNIKSTQPDIYPDLPPTKIEKKAAVILPLTETLDRWPEGVDIERNGPEL
What is the function of this protein?
N-acyltransferase required for nodulation.  Acts in the production of a small, heat-stable compound (Nod) that stimulates mitosis in various plant protoplasts.
What are the official names of this protein?
Nodulation protein A.
What is the protein family that this protein belongs to?
Belongs to the NodA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMDH_PHYB8
Sequence: MSLPNHSGSSAFKSFSYIVGTGIKRAAKLSTRNPIEMIVVVLILSSFSYFYLFNLARTSDIFSGTVTRLYPTSVYAPTKDHSFSVVDRTADSTIANNAVKVHLHQIVVSDPKHGVLSRQTLASVLRFQQMAENEIYVPDSTAVNRFAFNKDLCYKTTLPSSYSSHSSDSNSNSNLNSKTSPCFAHSPADIWQDEATLLADKNIRSTIEANLDTAKNVFGDLQLNATYASSVTLSYAFNTTGDYREHLADMWKHKVATLPPADLVSLSNIGQQENVFAWLFIVTRNVIFRVKELIDLADNIDIIVILVGYIMMIATFISLYVNMRAMGSRYTLATAVVFNGFFSFMLALLTVRALGVDVYPVVLAEAIPFLAVTIGFERPFKLTKRVFQFSKETPLTKQEIRTTIMRAVDTVALPIARDCFMEIIVLVLGAKSGISGLEEFCLLSAILLAYDFIIMFTWYTAVLALKLELLRIREINGISADDIKKGTKKSTGYIRRTVIKAFSDDHAAGANTANQKADGPIIGRVKLLMIVGFVVMHIFKFCSAFQSVGPQVNITEPSIAVVLDQLLEQHKASSQASLPLFVQVFPAMPFHVATVNKSFVPDAITRPLEALFDTYAVYIQHPVISKWLTIALFVSLFLNTYLFNVAKQPKQIVEQVNQDKKITNAIESTNNTHIEVTEKQKPTIQSPGPVVSSAVVMSPNHKRSHNHHHSHSHSHNHHSNHHQSDIVRPIDECVALVRTPEMLNDEEVISLVENGKMASYALEKVLGDLQRAVGIRRALISRASITKTLEASALPLENYHYDKVMGACCENVIGYMPIPVGVAGPMNIDGDLIHIPMATTEGCLVASTARGCKAINAGGGASTIVIADGMTRGPCVEFPTILRAAACKLWIENEGNDIVTNAFNSTSRFARLRKLKIALAGKLVFIRFSTTTGDAMGMNMISKGCEKALSIITEHFPDMQIISLSGNYCTDKKPAAINWIEGRGKSVVTEAVIPGAIVEKVLKTTVAALVELNISKNLIGSAMAGSVGGFNAHAANILTAIYLATGQDPAQNVESSNCITLMKAVNDTKDLHISCTMPSIEVGTIGGGTILPPQQSMLDMLGVRGPHPTEPGKNAQRLARIICAAVMAGELSLCAALAAGHLVKAHMAHNRGTQAPTITSGPAPSTGTEPGTCIKS
What is the function of this protein?
HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (Probable).  In this module, the cytosolic acetyl-CoA acetyltransferase catalyzes the formation of acetoacetyl-CoA (By similarity).  The hydroxymethylglutaryl-CoA synthase then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA (By similarity).  The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase hmgA (Probable).
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PSTB1_SYNJB
Sequence: MRPPFPGTPDSSKKSANLTVKLETQAVSVYYGSHLAVKQVSLKIPKNHITAFIGPSGCGKSTLLRCFNRMNDLIPGARVEGSVIFHGKNIYDPDVDPAEVRRRVGLVFQKPNPFPKSIYDNIAFGPRVNGYQGDLDELVERALRQAVLWDEVKDKLKTSGLSLSGGQQQRLCIARTLAIQPEVILMDEPCASLDPISTLRIEELLKELGRRYTIIIVTHNMQQAARVSDFTAFFNTEVDEEGFRYGRLVEFNRTEKIFNSPAHRETEEYVSGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KAD_LACAC
Sequence: MINLILLGLPGAGKGTASERIVDKYHLTHISTGDMFREAMANKTKVGLEAKSYIDKGNLVPDEVTARLVEERLSQPDIKEGYILDGFPRTTVQAELLEGITKRLKKPLTNVIALEVDEDTLIKRLSARYMCKNCGATYNKISKQPKVEGTCDRCGSHEFYQREDDKPEVVKNRLEVNEKMNAPLKDFYQKKGLLTIINGEQTPEKVFEDIDAVLSNNQ
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_CHLPD
Sequence: MENAIRSLQQEISEYELASIKDIEAFRLRYTVRKGLIAGLFGQLKSVLPADKPRMGQLLNQLRQTADDKLAAATAELASAESKTEPKLDLTLPGRRTFIGSEHPVQKVLGEMKGIFSSMGFSIATGPELELDRYNFDLLNFPPDHPARDMQDTFFITRGNANGDVLLRTHTSPVQIRVMLDQKPPIRVICPGKVYRNEAISSRSYCVFHQLEGLYIDKGVSFADLKATIFSFAHQMFGSDVKLRFRPSFFPFTEPSAEVDVSCYLCGGKGCRVCKKSGWLEIMGCGMVHPNVMRNSGIDPEKWSGYAFGMGVDRTVLLRYKIDDIRLLFENDVRMLRQFPA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y866_FRATN
Sequence: MYQNHKSEILLATPLIKDDIVFTKSVVYLCQNDRHGAMGLIINKPLADTLKDVFEELHIPHTNTFKEILEYPLYMGGPISPHKIMILHTTNGRNYTSTIKLDEGLAITASIDILEDIANNILPEYFLPVVGYSCWTANQLTDEIKSNDWIVTNKLNKKILFNHENKVKWQNHLEHAGYTLQSLDTLFNRNTGNC
What are the official names of this protein?
UPF0301 protein FTN_0866.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: DCO_DROME
Sequence: MELRVGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGIPRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIKPDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPWQGLKAANKRQKYERISEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHFDQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGGPRNPQAIQQAQDGADGQAGHDAVAAAAAVAAAAAASSHQQQQHKVNAALGGGGGSAAQQQLQGGQTLAMLGGNGGGNGSQLIGGNGLNMDDSMAATNSSRPPYDTPERRPSIRMRQGGGGGGGGVGVGGMPSGGGGGGVGNAK
What is the function of this protein?
Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim).  Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation.  No evident circadian oscillation is detected in head.  Together with CkIalpha, regulates processing of ci by phosphorylating it, which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase (PubMed:16326393).
What are the official names of this protein?
Discs overgrown protein kinase, Protein double-time.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Protein: TPCM_ASPFU
Sequence: MAVPQSIPPPTAAPIESKDQVFARSKAFWDNYLRGRPQVPPSFFQRIYRYHREHGGRFGTVHDVGAGIGPYAGELRSQFPHVIVSDIVPKNVQLAEAHLGRDGFRYRAAPVEVADDLPPGSVDLAFATNVMHFADQHAAMQAIATQLRPGGTFACAGFGPARFDDPDIQDVWERISQQGGRILLGMAEHPPDTINVMSRSSKEYNVAPLEPQWFRPGALRIRLNMAQGGITGLLPPERQQEVTDPDFAGPRDVVVYETNEEWRFETDWEGFLQHFRSFPHAGADPAAFTGLLQELKDLLDEGRCLRGCWPATLILATRR
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process (PubMed:26278536, PubMed:26242966).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC (PubMed:26242966).  The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC (PubMed:26242966).  The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone (PubMed:26242966).  The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin (PubMed:26242966).  Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:26242966).  Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity).  Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH.  Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin (PubMed:26242966).  Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death (PubMed:22319557).  The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway (PubMed:26242966).
What are the official names of this protein?
Methyltransferase tpcM, Geodin synthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: RS17_BRUME
Sequence: MPKRVLQGVVVSDKNDKTVVVKVERRYSHPLLQKTVRQSKKYKAHDENNQFKVGDFVSIQESAPISKDKRWVVLTSEAAG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RL2_STRU0
Sequence: MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVSLKNKAGRNNNGRITVRHQGGGHKRHYRVIDFKRNKDNVEAVVKTIEYDPNRTANIALVHYTDGVKAYIIAPKGLEVGQRIISGPEADIKIGNALPLANIPVGTVIHNIEMKPGKGGELVRAAGASAQVLGQEGKYVLVRLQSGEVRMILGTCRATIGSVGNEQQSLVNIGKAGRNRWKGVRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIIRRRNEK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: FMTA_STAAR
Sequence: MKFNKEKLVIHACVLLFIIISIGLVFHRLQTKTNSIEPIHKETKLSDNAKYLVDRNKGKGEPSKLKEVYNSKDPKYKKIDRYLQNSLFNGSVAVYENGKLKMSKGYGYQDFEKGIKNTPNTMFLIGSAQKFSTGLLLKQLEEEHKININDPVSKYIPWFKTSKPIPLKDLMLHQSGLYKYKSSKDYKNLDQAVRAIQKRGIDPKKYKKHMYNDGNYLVLAKVIEEVTGKSYAENYYTKIGDPLKLQHSAFYDEKSFRKYFAKGYSYNSTGLSFLKPNVLEQYYGAGNIYMTPTDMGKLITQIQQYKLFSPKITNPLLHEFGTKQYPDEYRYGFYVKPTLNRLNGGLFGQVFTVYYNDKYVVVLALNVKGNNEVRIKHIYNDILKQNKPYNTKGVIVQ
What is the function of this protein?
Catalyzes the liberation of D-alanyl moieties present on wall teichoic acid (WTA) and lipoteichoic acid (LTA).  Affects the methicillin resistance level and autolysis in the presence of Triton X-100 as well as the cell wall structure.
What are the official names of this protein?
Teichoic acid D-alanine hydrolase, Teichoic acid D-alanine esterase.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: AROA_PARL1
Sequence: MASPSNHSASSLTAEPSGALLGSITVPGDKSISHRALIFGALAVGETRIGGLLEGEDVLATAETMRRLGAEVERHADGTWSVHGVGVGGLKEPDQPLDFGNSGTGARLVMGLVAGHPITATFIGDASLSRRPMGRVIAPLTETGATFHAREGGRLPLTLTGAGRALPITYRLPVASAQVKSAVLLAGLNAPGVTTVIEETPTRDHTERMLRAFGAHIEVEDGPRGLIVIRLTGEPELKPCRISVPGDPSSAAFPVVAALLTPGSEITVTGITLNPHRAGLYTTLMEMGGDIEVMNQREEGGEPVADLRVRASRLKGIEVPPARAASMIDEYPVLAIAAAFAEGETRMLGIHELRVKESDRIAATASGLRANGVKVHESDDGMVVEGRSGEVGGGGHVATHIDHRIAMSFLVMGLAAQKPVTVDDAAMIATSFPNFTGLMRGLGASFVGRAQ
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO_KLEPN
Sequence: GTEVVVDQQKTISALLGASPGASTAAPITLNVLKQMFPQQFNSPEWQSRIHAIVPSYGQKLNGNVALTQQVWDDTAATLQLTKPPVIQMPAAAPTATAKPAETPREASPQHDMAL
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: STS1_ARTOC
Sequence: MNSLIATPPVPPHFYETSCRSPSYSMSSTNTSVNRKRKAEDDCPPSGDTRMSASPSGSPALHPRPLAPRHLKRPRPNVSGRPLSLPRLMETLDTDALRSVLRSLCDRHPEIASEVMHTAPRPSVSAALEVLSNYQSTLQSSFPLGGNPSSDYAYNRVRQHLTNLLEALNDFTPHFLPPNESQPSTSLSYLDGATDIIHRLPRWTTPQHNIEEYAATEAGTKNWQSTNETAGGKLQDALKRAQPEPWVDRWQTWATRATALRETSRRYANSSCRAHTVLAYRSKSGHGNSIQYQSSKPHFLFSTFNPSIHPSITALLSTPHYTVQVDGFRAIFNETITIPIC
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome STS1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PIMT3_GEOUR
Sequence: MRVIILAFALLLTTASVLSSATDPYLQKRQEMVRDDIRGRGIKDGRVLDAMAKIPRHLFVGERLRRQAYADTPLPIGEGQTISQPYVVALMTEALRLKPGDRVLEIGTGSGYQAAVLAEMVKDVYSIEIRKDLAETADKRLKELGYKNVAVKYGDGYLGWPEYAPFDAVIITASVNHIPPPLLKQLKEGGRLILPLGSTLFYQTLTLVTKKKGGDLAVEQMGAVAFVPMTGEAQKR
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase 3, L-isoaspartyl protein carboxyl methyltransferase 3, Protein L-isoaspartyl methyltransferase 3, Protein-beta-aspartate methyltransferase 3, PIMT 3.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.