PharMolix/UniProtQA huggingface dataset:
Protein: FURIN_MOUSE
Sequence: MELRSWLLWVVAAAGAVVLLAADAQGQKIFTNTWAVHIPGGPAVADRVAQKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKRRAKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNADDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVTACLGEPNHITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLSTPPESSGCKTLTSSQACVVCEEGYSLHQKSCVQHCPPGFIPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSSRESRPQQQPPALRPEVEMEPRLQAGLASHLPEVLAGLSCLIIVLIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
What is the function of this protein?
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:18713856).  Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity).  Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-45) (By similarity).  By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (PubMed:18713856).
What are the official names of this protein?
Furin, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE, Prohormone convertase 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family. Furin subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single- pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
Protein: PI15_HUMAN
Sequence: MIAISAVSSALLFSLLCEASTVVLLNSTDSSPPTNNFTDIEAALKAQLDSADIPKARRKRYISQNDMIAILDYHNQVRGKVFPPAANMEYMVWDENLAKSAEAWAATCIWDHGPSYLLRFLGQNLSVRTGRYRSILQLVKPWYDEVKDYAFPYPQDCNPRCPMRCFGPMCTHYTQMVWATSNRIGCAIHTCQNMNVWGSVWRRAVYLVCNYAPKGNWIGEAPYKVGVPCSSCPPSYGGSCTDNLCFPGVTSNYLYWFK
What is the function of this protein?
Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727).  May play a role in facial patterning during embryonic development (By similarity).
What are the official names of this protein?
Peptidase inhibitor 15, PI-15, 25 kDa trypsin inhibitor, p25TI, Cysteine-rich secretory protein 8, CRISP-8, SugarCrisp.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGB_CHLL3
Sequence: MKETDSLTCSDLRPARKAPQTAIGQVLIEALPYIRKFERKTFVIKYGGSAMKDLCLKNSFAQNVTLLRKVGINVVLVHGGGDAITKTAEKLGITSTFVHGKRVTDKEMISVVQMTLAGKVNQDIVQLISEHGGKAVGVTGLDADTIQAVPCRDAATLGLVGEIESINTAYIDLLCKAGLIPVIAPIGFDDDGNIYNINADDAASSIAIALKAEKLIYVSDVAGIQVGERILKTICKAEAADFIEQGIITGGMIPKVLSGFLTLDGGVRKIHIIDGKSVHSLLLEIFTHEGVGTQFISEQDDESNH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISY1_MOUSE
Sequence: MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGNQEKAGEDGQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEAKRLLGY
What is the function of this protein?
Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation (PubMed:26255770, PubMed:29804889).  Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (PubMed:26255770).  Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (PubMed:29804889).  Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (PubMed:29804889).  By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes the transition to the primed state (PubMed:29804889).  Involved in pre-mRNA splicing as component of the spliceosome.
What are the official names of this protein?
Pre-mRNA-splicing factor ISY1 homolog.
What is the protein family that this protein belongs to?
Belongs to the ISY1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL36_MYCLE
Sequence: MKVNPSVKPMCDKCRVIRRHRRVMVICVDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: CMAS2_MYCTU
Sequence: MTSQGDTTSGTQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCAYFERPDMTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGSTMRHAVAEYDVNVIGLTLSENQYAHDKAMFDEVDSPRRKEVRIQGWEEFDEPVDRIVSLGAFEHFADGAGDAGFERYDTFFKKFYNLTPDDGRMLLHTITIPDKEEAQELGLTSPMSLLRFIKFILTEIFPGGRLPRISQVDYYSSNAGWKVERYHRIGANYVPTLNAWADALQAHKDEAIALKGQETYDIYMHYLRGCSDLFRDKYTDVCQFTLVK
What is the function of this protein?
Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine.  In the absence of MmaA2, CmaA2 has a non-specific cis-cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid.  Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
What are the official names of this protein?
Cyclopropane mycolic acid synthase 2, CMAS-2, Cyclopropane-fatty-acyl-phospholipid synthase, CFA synthase, Cyclopropane fatty acid synthase, Mycolic acid methyltransferase, MA-MT, S-adenosylmethionine-dependent methyltransferase, AdoMet-MT, SAM-MT.
What is the protein family that this protein belongs to?
Belongs to the CFA/CMAS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT453_HUMAN
Sequence: MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGDSLIAGSAMSKEKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSFSGDDLECRETASSPKSQREINADIKRKLVKELRCVGQKYEKIFEMLEGVQGPTAVRKRFFESIIKEAARCMRRDFVKHLKKKLKRMI
What are the official names of this protein?
Cancer/testis antigen family 45 member A3, Cancer/testis antigen 45-3, Cancer/testis antigen 45-4, Cancer/testis antigen 45A3, Cancer/testis antigen 45A4, Cancer/testis antigen family 45 member A4.
What is the protein family that this protein belongs to?
Belongs to the CT45 family.
Protein: TGB3_PVXX3
Sequence: MEVNTYLNAIILVLVVTIIAVISTSLVRTEPCVIKITGESITVLACKLDAETIKAIADLKPLSVERLSFH
What is the function of this protein?
Plays a role in viral cell-to-cell propagation, by facilitating genome transport to neighboring plant cells through plasmosdesmata.  May induce the formation of granular vesicles derived from the endoplasmic reticulum, which align on actin filaments.
What are the official names of this protein?
Movement protein TGBp3, 7 kDa protein, Triple gene block 3 protein, TGBp3.
What is the protein family that this protein belongs to?
Belongs to the Tymovirales TGBp3 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane.
Protein: GAG_MMTVB
Sequence: MGVSGSKGQKLFVSVLQRLLSERGLHVKESSAIEFYQFLIKVSPWFPEEGGLNLQDWKRVGREMKRYAAEHGTDSIPKQAYPIWLQLREILTEQSDLVLLSAEAKSVTEEELEEGLTGLLSTSSQEKTYGTRGTAYAEIDTEVDKLSEHIYDEPYEEKEKADKNEEKDHVRKIKKVVQRKENSEGKRKEKDSKAFLATDWNDDDLSPEDWDDLEEQAAHYHDDDELILPVKRKVVKKKPQALRRKPLPPVGFAGAMAEAREKGDLTFTFPVVFMGESDEDDTPVWEPLPLKTLKELQSAVRTMGPSAPYTLQVVDMVASQWLTPSDWHQTARATLSPGDYVLWRTEYEEKSKEMVQKAAGKRKGKVSLDMLLGTGQFLSPSSQIKLSKDVLKDVTTNAVLAWRAIPPPGVKKTVLAGLKQGNEESYETFISRLEEAVYRMMPRGEGSDILIKQLAWENANSLCQDLIRPIRKTGTIQDYIRACLDASPAVVQGMAYAAAMRGQKYSTFVKQTYGGGKGGQGAEGPVCFSCGKTGHIRKDCKDEKGSKRAPPGLCPRCKKGYHWKSECKSKFDKDGNPLPPLETNAENSKNL
What is the function of this protein?
Capsid protein.
What are the official names of this protein?
Gag polyprotein.
What are the subcellular locations of this protein?
[Matrix protein p10]: Virion. SUBCELLULAR LOCATION: [Capsid protein p27]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p14]: Virion.
Protein: SYDND_HAHCH
Sequence: MRSHYCGEVNESLVDQEVTLCGWVHRRRDHGGVIFLDLRDRDGIAQVVYDPDTNEVFQLAEQIRDEFVVKVTGRVRLRPEGKANTDMSTGMVEVLGKQLEILSTAKTPPFQLDEFVQVGEDVRLRYRYMDLRRPEMLNKLRFRSKVTSYIRNFLDGNGFMDVETPILTRATPEGARDYLVPSRTHEGSFFALPQSPQLFKQLLMMSGVDRYYQIAKCFRDEDLRADRQPEFTQVDIETSFLNENEIMSITERLVRDMFRDLLEVELPEFPRMPFSEAMNRYGSDKPDLRIPLELVDVGDLLTNVSFNVFSGPANDPKSRVAALRLPKGGELLSRKQIDDYTKFVGIYGAKGLPYIKVNEKAKGLDGLQSPIVKHIADAIDPLLERVGAEDGDIIFFGTDKTRVVNEALGALRVKLGHDLNLLEKQWAPLWVVDFPMFEEDGEGGWTAIHHPFTAPSCAVEMLESDPENALSRAYDMVLNGTELGGGSVRIHDSDMQETVLRILGIGQDEAREKFGFLLDALKFGCPPHGGLAFGLDRLVMLMTGAQSIREVIAFPKTQSAMCMMTQAPGKVDPKQLRELNIRLRKTEQPE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1559_STRS2
Sequence: MFEKKNRTCLTVYLHYNRDARKLSQYGDIVYHSKRLRYVLVYMDQELVEATILKLKKERFVKKVVPSYIKELDQNFVGNLWRDEEPSVVG
What are the official names of this protein?
UPF0298 protein SSU98_1559.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPDF_SPHAL
Sequence: MTESAAPSPRCVAAILLAGGRGLRAGFGRPKQLEWLCGKPVLRWSLDVLAGYPGLSGGVLVANHDVMAATYPLPEGWMAADPGVERQQSVANALSALTDWPDDAVVLVHDAARPGVDSAVVDRLLAALDGADAAIPVLPVPDTLVEAADGAAGAVVARDRLARVQTPQAFRLGTLRRAHAEASGAAATDDAQLVRSLGVSVATVEGDARLHKLTYAADMAILAGLLGTKDMMRTAVGMGYDVHRLVEGKPLWIGGIEIAHSHGLEGHSDADVGLHALTDAILGALGDGDIGDHFPPSDPQWRGAASHHFLSFAGERVAANGGRIGHLDLTIIAEAPRIGPHRVAIRDRIAEILAIPAGRVSVKATTTERLGFTGRREGIAAQAVATIQLPET
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: PUP_KOCRD
Sequence: MAQERIFGTGSRREDEPDTPAPVDPPVSGAAQAQRDMQGTDDLLAEIDGVLETNAEAFVKGFVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: ERIC2_HUMAN
Sequence: METVNEPETGEVSKDAVIVKQEKNNEYCLQDIDDKLSESAEDDGEDDTNDEDDDEDSNPKKNTQAPLELMAEFLRAEMAREYQLAKKLCQMILIYEPENPEAKEFFTLIEEMLLMEKTQNHEQDGENSDEDSSGESKGESDEELSDESSDEGEDGS
What are the official names of this protein?
Glutamate-rich protein 2.
Protein: RPB8B_ARATH
Sequence: MASNIIMFEDIFVVDKLDPDGKKFDKVTRVEARSHNLEMFMHLDVNTEVYPLAVGDKFTLAMAPTLNLDGTPDTGYFTPGAKKTLADKYEYIMHGKLYKISERDGKTPKAELYVSFGGLLMLLQGDPAHISHFELDQRLFLLMRKL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements.
What are the official names of this protein?
DNA-directed RNA polymerases II, IV and V subunit 8B, RNA polymerase Rpb8.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IMDH_LEIDO
Sequence: MATNNANYRIKTIKDGCTAEELFRGDGLTYNDFIILPGFIDFGAADVNISGQFTKRIRLHIPIVSSPMDTITENEMAKTMALMGGVGVLHNNCTVERQVEMVKSVKAYRNGFISKPKSVPPNTPISNIIRIKEEKGISGILVTENGDPHGKLLGIVCTKDIDYVKNKDTPVSAVMTRREKMTVERAPIQLEEAMDVLNRSRYGYLPIVNENDEVVNLCSRRDAVRARDYPHSTLDKSGRLICAAATSTRPEDKRRVAALADVGVDVLVLDSSQGNTIYQIAFIKWVKSTYPHLEVVAGNVVTQDQAKNLIDAGADGIRIGMGSGSICITQEVLACGRPQGTAVYKVAQYCASRGVPCTADGGLRQVGDICKALAIGANCAMLGGMLSGTTETPGEYFFKGGVRLKVYRGMGSLEAMSQGKESGKRYLSENEAVQVAQGVSGNVVDKGSAAKLIAYVSKGLQQSAQDIGEISFDAIREKMYAGQVLFSRRSPTAQGEGGVHSLHSYEKKLFAAKM
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Glycosome.
Protein: LACC_STAAS
Sequence: MILTLTLNPSVDISYPLTALKLDDVNRVQEVSKTAGGKGLNVTRVLAQVGEPVLASGFIGGELGQFIAKKLDHADIKHAFYNIKGETRNCIAILHEGQQTEILEQGPEIDNQEAAGFIKHFEQLLEKVEAVAISGSLPKGLNQDYYAQIIERCQNKGVPVILDCSGATLQTVLENPYKPTVIKPNISELYQLLNQPLDESLESLKQAVSQPLFEGIEWIIVSLGAQGAFAKHNHTFYRVNIPTISVLNPVGSGDSTVAGITSAILNHENDHDLLKKANTLGMLNAQEAQTGYVNLNNYDDLFNQIEVLEV
What are the official names of this protein?
Tagatose-6-phosphate kinase, Phosphotagatokinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
Protein: GUF1_BLAGS
Sequence: MRGCLQSVKWLTSAVRQSQSLTSSTRFPRRLFNTSTLHYAQGRKPVSELEQRIAAIPIERFRNFCIVAHVDHGKSTLSDRLLELTGTIEAGANKQVLDKLDVERERGITVKAQTCSMLYNHQGEDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGIQAQTVANFYLAFAEGLKLVPVINKVDLPSADPERALDQMKNTFELDPKSAVLVSAKTGLNVEQLLPTVIEQVPAPVGDHTKPLRMLLVDSWYSTYKGVILLVRIFDGEVRAGDQVVSFATGLKYFVGEVGIMYPGQTAQSVLRAGQVGYIYFNPAMKRSQEAKVGDTYTKVGSEKLVQPLPGFEEPKAMVFVAAYPVDASDFPHLEDSINQLTLNDRSVTLQKESSEALGAGFRLGFLGTLHCSVFEDRLRQEHGASIIITPPTVPFKVIWKDGKEEIVTNPALFPEEETLRAKVAELQEPFVLATLTFPEEYLGRVIELCESNRGEQKNLEFFTSTQVILKYELPLAQLVDDFFGKLKGSTKGYASLDYEESGWRRSNISKLQLLVNKVPVDAVSRVVHASQVQRLGRLWVSKFKEHVDRQMFEIVIQAAVGRNVVARESIKPFRKDVLQKLHASDITRRKKLLEKQKEGRKRLKAVGNVVIEHKAFQAFLAK
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RNT_HAES1
Sequence: MTALSEQAVDYNLLKNRFRGFFPVIIDVETAGFNAQTDALLELAAITLKMDENGLLVPDEKCHFHIQPFEGANINPESLKFNGIDIDNPLRGAISENVAMSELFKMVRHGQKKADCQRSVIVAHNATFDQSFVMAAAERTKIKRNPFHPFSIFDTATLSGFMFGQTVLVKGCQVANISFDGKKAHSALYDAERTAELFCYMVNHLKKLGGFPHVAINS
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: RL6_NITWN
Sequence: MSRIGKRPVTVPSGVTATVEGQTVKMKGPKGELRFVVHDDVEVKLEDGAVKVAPRYETKRAQALYGTARAQVANLVAGVTKGFEKKLEIIGVGYRAALQGKSLQLALGYSHDVNYAVPEGITIAVPKPTEITITGNDAQRVGQVAAEIRGYRPPEPYKGKGVKYADETIFRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: MSCL_SALTI
Sequence: MSFIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAFTLREAQGDIPAVVMHYGVFIQNVFDFVIVAFAIFVAIKLINRLNRKKAEEPAAPPAPSKEEVLLGEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL10_FRAP2
Sequence: MALRIEDKKAIVAEVAEQVSSALSAAVADYRGLTVNEMTSLRKQARESGVYLRVVRNNLARLAIKGTDFECLGDALKGPLVLALSKDEPGAAAKLFKSFQKDHNAFEVKNLAMSGELFGPEKLDDFAKLPTREEALATLLNVMQAPVTKFVRTLNEIPSQAVRVFAAVGDSK
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RS18_DINSH
Sequence: MAAKPFFRRRKVCPFSGDNAPKIDYKDTRLLQRYISERGKIVPSRITAVSAKKQRELARAIKRARFLALLPYAVK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MIAB_SHEHH
Sequence: MSKKLHIKTWGCQMNEYDSSKMADLLDEYEGYTLTDNAEEADVLLLNTCSIREKAQEKVFHQLGRWKTLKDKKPELIIGVGGCVASQEGKAIKERAQCVDLIFGPQTLHRLPEMIDQIRAGKKAVIDVSFPEIEKFDRLPEPRADGPSAFVSIMEGCSKYCSFCVVPYTRGEEVSRPLDDIILEIAQLAEQGVREVNLLGQNVNAYRGATHDDEICTFAELLRYVAAIDGIDRLRFTTSHPIEFTQDIIDVYEDTPELVSFLHLPVQSGSDLILTQMKRGHMAIEYKSIIRRLRKARPDILISSDFIIGFPGESKQDFADTMKLIEDIQFDHSFSFIYSARPGTPAADLPDDVSLDEKKERLAILQDRITQQAMRYSRQMVGTVQRILVEGPSVKNPMELRGRTENSRVVNFEGMHKHIGKFVDVEIVDVYTNSLRGVFIRGEDEMDLRRDLRPSDITAKYKQTDDLGVSQFKPA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMA_YERPY
Sequence: MTPNILPIESYDHQLAEKSARLKAMMLPFQAPEPEIFRSPADHYRMRAEFRVWHDEDDLYHIMFDQQTKQRIRVEQFPVASRLINRLMDALMTAIRAEPLLRRKLFQIDYLSTLSGKLIASLLYHRQLDEEWQQKALELRDQLRAQGFDLQLIGRAAKTKIMLDHDYIDEVLPVAGREMIYRQVENSFTQPNAAVNIHMLEWALDVTQGATGDLLELYCGNGNFSLALARNFERVLATEIAKPSVAAAQYNIAANNIDNVQIIRMSAEEFTQAMQGVREFNRLKGIDLGSYNCETIFVDPPRSGLDHETVKLVQAYPRILYISCNPETLCANLEQLQHTHKISRLALFDQFPYTHHMECGVLLEKRH
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: MIAA_SHIFL
Sequence: MSDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSVLIYKGMDIGTAKPNAEELLAAPHRLLDIRDPSQAYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEVDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQARDEVLQVVGAIAG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: DFB1_EMYOR
Sequence: YDLSKNCRLRGGICYIGKCPRRFFRSGSCSRGNVCCLRFG
What is the function of this protein?
Has antimicrobial activity against the Gram-positive bacteria methicillin-resistant S. aureus ATCC 33591 and L. monocytogenes EGD, the Gram-negative bacterium E. coli ML53p and the yeast C. albicans 820.  Has no hemolytic activity towards human erythrocytes.
What are the official names of this protein?
Beta-defensin 1, TBD-1.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles.