PharMolix/UniProtQA huggingface dataset:
Protein: RT19_DICCI
Sequence: MVRSRWKGIYVAKELQNYNTVSNPTIVTTERSSVIIPYYLSKTIYVYNGRKYVGVKITEKSLGRKLGEYVLTKKVEKYKASKKVKKK
What are the official names of this protein?
Ribosomal protein S19, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HEXC_BOMMO
Sequence: MWLQAICIYTVFIIIGCGIPTAAEEHSLWRWTCENNRCTKIRNEPENKEPVLSLEACKMFCDDYGLLWPKPTIETNLGNFLSKINMNTIDIQITKQGKSDDLLTAAADRFKTLVSSSVPKGFSAKAAGKSVTVYLVNENPYIREFSLDMDESYELYISSTSSDKVNATIRGNSFFGVRNGLETLSQLIVYDDIRNNLLIVRDVTIKDRPVYPYRGILLDTARNFYSIDSIKRTIDAMAAVKLNTFHWHITDSQSFPLVLQKRPNLSKLGAYSPTKVYTKQDIREVVEYGLERGVRVLPEFDAPAHVGEGWQDTGLTVCFKAEPWTKFCVEPPCGQLNPTKEELYDYLEDIYVEMAEAFESTDMFHMGGDEVSERCWNSSEEIQNFMIQNRWNLDKSSFLKLWNYFQKNAQDRAYKAFGKRLPLILWTSTLTDYTHVEKFLDKDEYIIQVWTTGADPQIQGLLQKGYRLIMSNYDALYFDCGFGAWVGSGNNWCSPYIGGQKVYGNSPAVMALSYRDQILGGEVALWSEQSDPATLDGRLWPRAAAFAERMWAEPSTAWQDAEHRMLHVRERLVRMGIQAESLEPEWCYQNQGLCYG
What is the function of this protein?
Active during metamorphosis to degrade chitin.
What are the official names of this protein?
Chitooligosaccharidolytic beta-N-acetylglucosaminidase, Beta-GlcNAcase, Beta-N-acetylhexosaminidase, Beta-hexosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 20 family.
Protein: MURI_VIBCH
Sequence: MSSPSFPRVLIFDSGVGGLSVYREIEARLPQLNYIYLFDNAAYPYGELTQETLIARVDTLVTRMVEQERIDLVVIACNTASTIVLPVLRAKLTIPVVGVVPAIKPASLIASKAIGLIATPATVKRQYTQELIRDFSANKNVELLGSTRLVNMAEEKLRGKPLDLEELASILQPLKNTIDVAVLGCTHFPLIKEEIQQVLGEQVQLIDSGLAIARRVQELLGIEQAVGAKQKHRIYASAPPWEESALNIKLEQLGFNPVQPFLHPI
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: PWP2_SCHPO
Sequence: MKTEFGFSNLVGTIFSKGNLVFTPDGFSILSPVGNRVSVYNLKDNTSYTFPFENHKNISHIALSPTSTLLLSVDEEGRCILCNFLRRSVLHYFNFKSPVGAIEFSPNGKFFAVSLGKLIQVWRTPNSLEEREFAPFVLHREYTGHFDDIVSISWSADSRFFISTSKDLTARLHSVDPIEGFHPCALTGHKNTVVSGFFSKDQQTIYTVSKDGALFVWKYSPLFQAGEVIDEEAEENKTRTHIWLIKERHYFNQNSKLRCAAFHPTSNLLVVGFSSGLFGIYELPSFTMLYQLSITQSNIDTLTVNSTGDWIAIGSSKLGQLLVWEWQSESYVLKQQSHYDALSTLQYSSDGQRIITGADDGKIKVWDMNSGFCIVTFTQHTSAVSGLCFSKRGNVLFSSSLDGSVRAWDLIRYRNFRTFTAPSRVQFSCIAVDPSGEIVCAGSQDSFEIFMWSVQTGQLLETLAGHEGPVSSLSFNSSGSLLASGSWDKTVRIWDIFSRSGIVEPLPIPSDVLSLAFHPDGKEVCVASLDGQLTFWNVQEGKQTSLIDGRKDLSGGRRFDDARTAENSSLNKTFTSICYSADGSCVLSAGTSKYVCLYDIITGVLIKKFQLSKNESLQGVQEMLNSRKMTEAGSIELIDTQGEESDLEDRIDRTLPGARRGDLSARKTRPEIICHGVQFSPSGGAFAAATTEGLMIYSLYNDFLFDPINLDMDITPSTTLTMCAEGEFLISLVMALRLNEYKVVQKVYESIPITDVEHVVQELPVSYLANFMGYLSSFAAETPHIEFHLRWMKSVLTYHGEYLRRKNFEFASQLTSLQKSIVVLSKRLSQLSSNNEFQLSFLLDKMHLRLENTA
What are the official names of this protein?
Periodic tryptophan protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PWP2 family.
Protein: CAPSD_TOML
Sequence: MSYSITSPSQFVFLSSVWADPIELLNVCTNSLGNQFQTQQARTTVQQQFSEVWKPFPQSTVRFPGDVYKVYRYNAVLDPLITALLGAFDTRNRIIEVENQQSPTTAETLDATRRVDDATVAIRSAINNLVNELVRGTGLYNQNTFESMSGLVWTSAPAS
What is the function of this protein?
Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.
What are the official names of this protein?
Capsid protein, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: Y1413_SHEB8
Sequence: MLGWTLVFLVVAVIAGLFGFTGIAGAAAGIAKIIFFLFIVLLVISLLINALKGKSPRL
What are the official names of this protein?
UPF0391 membrane protein Shew185_1413.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIBBA_BREBN
Sequence: MFHSIEEALEDLRQGKAVIVVDDEDRENEGDFVCMAEAATPEMINFMVTHGRGLVCVPVTEEHATRLQLAPMVNANTDKQGTAFTVSIDEGSTNTGISAHERSQTVLAMLDEQKDADDFRRPGHIFPLIAKAGGVLRRAGHTEAAVDLARLAGGIPAGVICEIMNEDGSMARLPQLVEIARRFDLKLITIADLIAYRMRTESMVKKEIEVQLPTAYGDFRIAAYTNELDGKEHVALIKGEIGPDEPILVRVHSECLTGDIFGSYRCDCGPQLHAALEQIEANGRGILLYMRQEGRGIGLINKLRAYKLQEEGLDTVEANEKLGFAADLRDYGIGAQILRDLGVQRMRLLTNNPRKIRGLTGYGLAVEERVPLQTPEHLHNKQYLSTKQEKLGHLLHLNG
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: PSB4_YEAST
Sequence: MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQIDYLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQAQ
What is the function of this protein?
Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus.  It is essential for the regulated turnover of proteins and for the removal of misfolded proteins.  The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  It has an ATP-dependent proteolytic activity.  This subunit has a chymotrypsin-like activity.
What are the official names of this protein?
Proteasome subunit beta type-4, Macropain subunit C11, Multicatalytic endopeptidase complex subunit C11, Proteasome component C11, Proteinase YSCE subunit 11.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ELOV2_HUMAN
Sequence: MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVMYLLSIWLGNKYMKNRPALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDLTSAGEADIRVAKVLWWYYFSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTMSAVVKPCGFPFGCLIFQSSYMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVKNGFSKAYFTAANGVMNKKAQ
What is the function of this protein?
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle.  This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.  Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA.  May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
What are the official names of this protein?
Elongation of very long chain fatty acids protein 2, 3-keto acyl-CoA synthase ELOVL2, ELOVL fatty acid elongase 2, ELOVL FA elongase 2, Very long chain 3-ketoacyl-CoA synthase 2, Very long chain 3-oxoacyl-CoA synthase 2.
What is the protein family that this protein belongs to?
Belongs to the ELO family. ELOVL2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi- pass membrane protein.
Protein: THI4_PUCGT
Sequence: MSPPVATESMYKPTTIGTEAHDQALAAMKSNQAAPAKPVFKPEPAVNLEPIKFAPIKEHQVQRAMVRRYFQDMEERAISDVIIVGAGSAGLSCAYALGKARPDLKITILESNVAPGGGCWLGGQLMSAMVCRKPADKFLDEVGVPYEDEGNFVVVKHAALFTSTVLSKVLAMPNVKMFNATACEDLIIKPCPINPGVQRVAGCVTNWTLVSLNHDHQSCMDPSTITAPLVCSFAGHDGPFGAFCVKRIASAGLSEGLGDMRPLDMERAEDHIANKTREIVPGLIVGGMELSEFDGSARMGPTFGAMLLSGKRAAEVALQSLGRVKVEEGEVVGSAK
What is the function of this protein?
Involved in biosynthesis of the thiamine precursor thiazole.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate.  The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.  May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
What are the official names of this protein?
Thiamine thiazole synthase, Thiazole biosynthetic enzyme.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FB257_ARATH
Sequence: MRRRSKKIKTENNSNPETSEERNKFDEIPHDLVIEILERLPLKSVARFLTVSKLWATTIRSPDFRKSYRGGSSSEPRTLIVSDLNFKEPNPKLHFFRPSISSPSFLSSLTCPFTYPRHEEYYYHHVNGLISVGYGTDQIVINPTTGKFITLPRPKTRRKLVISFFGYDSVSDQYKVLCMTERLRGHPEEASSQHQVYTLGAKQKSWKMINCSIPHRPWSWNAVCINGVVYYIAKTGEGMFRRCLMRFDLKSDNLDLCTILPEEIQTSLHDYFLINYKGKVAIPNQPNFYTYDVWVMNQEGGKIEWLKNITFTIKPRKGFVRYLFVTGTTHTGEFILAPTSYTDEFYVFHYNPDMNSFRKIRVQAPGVKFSFAQKASVVFSDHSLLRLDNLHIRGSTHTATGEFILAPRFYSDDLNVIHFNPDTNSFRSTKVEVYEDYE
What are the official names of this protein?
Putative F-box protein At5g15660.
Protein: SYDND_ANOFW
Sequence: MFGRTHYCGEVTDMAIGQTVRLKGWVQKRRDLGGLIFIDLRDRTGIVQIVFSPDVSKEALQVAETIRSEYVLDVEGTVVQREEGQVNPNLPTGTIEVHAMHVTILSEAKTPPFLISDKTDVSEDVRLKYRYLDLRRPVMFQTFKMRHQVTKAIRDFLDEEGFLEVETPILTKSTPEGARDYLVPSRVHPGEFYALPQSPQIFKQLLMVAGFERYYQIARCFRDEDLRADRQPEFTQVDIETSFMSQDDILAMIERMMARVMKVAKGVDISIPFPRMSYDEAIARYGSDKPDTRFGLELVDLSEQVKDCGFKVFASAVQNGGQVKAINVKGAADKYSRKDIDALTEYVARYGAKGLAWLKVEADGLKGPIAKFFTEDEQKQMMQTLEAETGDLLLFVADKKSVVADALGALRLKLGKDLQLIDESAFHFLWITDWPLFEYDEEEGRYYAAHHPFTMPVREDVPKFETDPASVRAQAYDLVLNGYELGGGSLRIFERDIQEKMFKTLGFTEEQAREQFGFLLEAFEYGTPPHGGIALGLDRLVMLLAGRSNLRDTIAFPKTASASCLLTEAPSAVSEEQLEELHLRIKDVQKVD
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNF_PSEF5
Sequence: MSRARGFAFALGSVALVSGAQLGMRWSMTRLPAPDQWLPALSAGSVDLAALAVVAAAIAAYALSMLCWLLALRDLPLGRAYSLLSISYALVYLLAASLPLFNEPFTLSKTLGVALVILGVITINSRSAPATSPRNTP
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LCL3_PARBP
Sequence: MRWLFWSSGSQQAPNSNKDNNNNNDGDDDNNNIIINNINRRPPLTLECPSPSHPPCASCSTKATTSPSNPKRGWNTSLTARDWAGEFKDPRNLIPTLLLTGGILFCVRIHRQYLRRIPLATNISPTYFHKRSLFGRVTSVGDGDNFRMYHTPGGRLAGWEWLPFRRVPRVKKELKDRTIHIRLAGIDAPELPHFGRPAQPYSHAAHTWLTNYLLNKRVRAFPYRQDQYGRVVATVYVRRFPWIFLRRDVGLQMLRAGMATVYEAKSGVEFGGEGKESKYRRAEEMAKRRGRGLWKGWKGAGWESPREYKNRMAGVEGERAAAGGGGGGVGGMGELGVNGGKN
What are the official names of this protein?
Probable endonuclease LCL3.
What is the protein family that this protein belongs to?
Belongs to the LCL3 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single- pass membrane protein.
Protein: NEED5_BPT4
Sequence: MSGLSYDKCVTAGHEAWPPTVVNATQSKVFTGGIAVLVAGDPITEHTEIKKPYETHGGVTQPRTSKVYVTGKKAVQMADPISCGDTVAQASSKVFIK
What is the function of this protein?
Baseplate central spike complex-associated protein.  Makes the tip of the central spike which probably punctures the host outer membrane, a necessary step for viral DNA ejection into the host cell.
What are the official names of this protein?
Baseplate puncturing device gp5.4, Gene product 5.4, gp5.4.
What are the subcellular locations of this protein?
Virion. Note=Present in the baseplate.
Protein: SSTT_HAEI8
Sequence: MNTSRLFSLLFQGSLVKRIAAGLVLGIVVALISAPLQETIGFNLAEKVGVLGTIFVKALRAVAPILIFFLVMAALANRKIGTKSNMKEIIVLYLLGTFLAAFVAVIAGFVFPTEVVLATKEDASSAPQAVGQVLFTLILNVVDNPLNAIFKANFIGVLAWSIGLGLALRHASDATKNVLSDFAEGVSKIVHVIISFAPFGVFGLVAETLSDKGLVALGGYVQLLAVLIGTMLFTAFVVNPILVYWKIRRNPYPLVWTCVRESGVTAFFTRSSAANIPVNIELAKRLNLDEETYSVSIPLGANINMAGAAITITILTLAAVHTLGLEVSFVSALLLSIVAALCACGASGVAGGSLLLIPLACSLFGISDDVAAQMIGVGFIIGILQDSTETALNSSTDVLFTAAVCMEEERKNAA
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSRP_BURP6
Sequence: MLPTVFIVSDGTGITAETFAHSILSQFDQKFRLVRVPFIDSIEKAYDTVRKINDAAQHDGRRPIVFTTLVDGESNEIVKRSNALVLDMFQRFVEPLEQELQLKSSHAMGRVHQNADTEEYKTRIEAINFSLAHDDGQSNRNLADADVILIGVSRSGKTPTSLYLAMQYGVKAANYPLIPEDFERGKLPTPLHPHRDKLFGLSIDPMRLSEIRNERRPGSKYAAPENCRYEINEAEAMMRREGVKWLSSTHKSIEEIATTILQEIKLERQSY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: QNN2_EMEVA
Sequence: MDAFKGAMSKTLEVFTFCNIILALASLVVAQCVYQIIYYRFFHPLRHYPGPFWASVTRLWGAYHFIKGDKLDLEWQAIKQYGPIIRTSPTMLLVADSTLMPAIYHRRDTKARFYLSEMFETSGSLVIRDPAKHAAHRRLISATYSMSNIKRMEPLLDKHILHFLEKLDSEYAQNAKPMDFSTWAAYLSYDTVTDLGFRNPLGFVDSASDVGGLIYQFRLGMLLFATSGYLYPLFRWLTTTWLKKWLIIRPEQALGFGVIMKRANEVLEERKRALTEGRIAKAVKGDASYDFLQAFMDTRTPEGEYLDNKTIRAEVFVILGAGADGFSSLSSAFIAEVLSRPAVYGRVMAEIKAAAIAGEFSQPVPLFTEITKNLPFFLACMQEIFRLHPTGATQLPREITPNDPELVLSGHKVPVGIEVTCNPWIINRDYNIYGDGAEVFNPDRWLGDPEKIKFYEKHSLTWGHGARFLMYFEVSICEETPETPKLESEIYGPVLGWKNVWLDLHKRRSWEQQ
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the pentacyclic sesterterpene quiannulatic acid (PubMed:27447198).  The first step of the pathway is performed by the sesterterpene synthase (QS) that possesses both prenyl transferase and terpene cyclase activity, converting isopentenyl diphosphate and dimethylallyl diphosphate into geranylfarnesyl diphosphate (GFPP) and further converting GFPP into quiannulatene via an unprecedented cyclization mode which involves three rounds of hydride shifts and two successive C-C bond migrations to construct the 5-6-5-5-5 fused ring (PubMed:27447198).  The cytochrome P450 monooxygenase Qnn-P450 then oxidizes quiannulatene at C-19 in 3 successive reactions to afford quiannulatic acid (PubMed:27447198).
What are the official names of this protein?
Quiannulatic acid synthase, Cytochrome P450 monooxygenase Qnn-P450, Quiannulatic acid biosynthesis cluster protein Qnn-P450.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IDI_SALTI
Sequence: MTEEHVVLLDEQDKPSGTLEKYAAHTLNTPLHLAFSCWLFNEDGQLLVTRRSLSKKAWPGVWTNSVCGHPQQGETTEEAIIRRCRFELGVEITDLTPVYPHFSYRATDPNGIVENEVCPVFAARATSVLQVNSEEVMDYQWSEFKSVWQSLLATPWAFSPWMVMQASDEQARKRLLNYCQR
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_CHLTA
Sequence: MLTLGLESSCDETSCSLVQNGKILANKIASQDIHASYGGVIPELASRAHLQTFPELLTAATQSAGVSLEDIELISVANTPGLIGALSIGVNFAKGLASGLKRPLIGVNHVEAHLYAACMEAPATQFPALGLAISGAHTSLFLMPDATTFLLIGKTRDDAIGETFDKVARFLGLPYPGGQKLEELAREGDADAFAFSPARVSGYDFSFSGLKTAVLYALKGNNSSAKAPFPEVSETQKRNIAASFQKAVFMTIAQKLPDIVKTFSCESLIVGGGVANNSYFRRLLNQICSLPIYFPSSQLCSDNAAMIAGLGERLFCNRTHVSKEVIPCARYQWESACS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_BACAA
Sequence: MATTKPYRVLLYYMYTTIENPEEFAAEHLEFCNSLELKGRILVAKEGINGTCSGTVEQTEKYMEAMNNDPRFDGIVFKIDEADGHAFKKMHVRPRPELVTLRLEDDINPHEITGKYLEPKDFYEAMKQEDTVIIDARNDYEFDLGHFKGAIKPDIESFRELPDWIRENKEVLEGKKILTYCTGGIRCEKFSGWLVREGYEDVSQLHGGIVTYGKDPEVQGELWDGQCYVFDERIAVPVNQKEHVIVGKDHFTGEPCERYVNCANPECNKKILCSEENEAKYLRACSHECRVSPRNRYVIQHELTEEQVAAALEKIEAGK
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: TRPD_HAEIG
Sequence: MQHNQLLEQLYSGHSLSTSESTALFNAVIQGELSNEQIAAMLIALKVREANTEEIAGAVAASLQNAKVFPRPDYPFADIVGTGGDGQNTINISTASAIVAASMGAKVAKHGNRSVSSKSGASDVLTALGVNVNVTPEQARQALDEIGVCFLFAQQYHSGFRHVAPVRAALKTHTIFNILGPLINPARPTYHLLGVYAPELVKTYAETAVALEHQHSFVVHGSGLDEVALHGETQVAEIKNGKIEYFTLTPEDFGLKTQSLESLRGGEPQKNAQYLTALLQGKGKAEHANTVAANTALLLKLFGYDDLKQNVQNVLAHLLSGKAFETLQKLTTY
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: MURG_SODGM
Sequence: MTAKTRRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTANRMEADLVPQHGIDIDFIRISGLRGKGLKAQLLAPVRIWRALRQARRIMRAWRPDVVLGMGGYVSGPGGLAAWSCGIPVVLHEQNGIAGLTNRGLAKISRKVLQAFPGAFPHADVVGNPVRDAVLALPAPEARFRDRTGPIRVLIIGGSQGARVLNQTMPAVAARLAGILTLWHQVGKGALEEVNRAYAANGETQHKVVEFIDDMAAAYAWADAVVCRAGALTVSEIAAAGLPALFVPFMHKDRQQYWNARLLEQACAAKIIEQPAFSVERVSDVLAGWDRPTLLTMAQRARAAAIPDATERVAREVAAAVRA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HMCES_HUMAN
Sequence: MCGRTSCHLPRDVLTRACAYQDRRGQQRLPEWRDPDKYCPSYNKSPQSNSPVLLSRLHFEKDADSSERIIAPMRWGLVPSWFKESDPSKLQFNTTNCRSDTVMEKRSFKVPLGKGRRCVVLADGFYEWQRCQGTNQRQPYFIYFPQIKTEKSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGEEAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESDVPQWSSQFLQKSPLPTKRGTAGLLEQWLKREKEEEPVAKRPYSQ
What is the function of this protein?
Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235915, PubMed:31235913).  Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913).  The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877).  Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877).  Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351).  Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity).  Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).
What are the official names of this protein?
Abasic site processing protein HMCES, Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, Peptidase HMCES, SRAP domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SOS response-associated peptidase family.
What are the subcellular locations of this protein?
Chromosome. Note=Recruited to chromatin following DNA damage (PubMed:30554877). Localizes to replication forks (PubMed:30554877).