PharMolix/UniProtQA huggingface dataset:
Protein: SIN1_SHEEP
Sequence: MGFLDNPTIILAHIRQSHVTSDDTGMCEVVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPNSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKISGPQYRLEKQRQPNVAVDLESTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTELQLGISGDKVEIDPVTSQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
What is the function of this protein?
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals.  mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive.  mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.  mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.  mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation.  mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'.  mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.  Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity.  MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation.  Inhibits HRAS and KRAS signaling.  Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription.  Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity).
What are the official names of this protein?
Target of rapamycin complex 2 subunit MAPKAP1, TORC2 subunit MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, Stress-activated map kinase-interacting protein 1, SAPK-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the SIN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Protein: Y933_GEOSM
Sequence: MSGHNKWSTIKHKKGAADAKRGKIFTKIIKEITVAAKLGGGDPDGNPRLRTAIDKAKGENMPKDNVERAIKKGVGGLEGTTYEETTYEGYGPGGTAVLVEVMTDNRNRTVSDVRSIFTKCNGNMGESGCVSWLFDKKGLLVFPKSIDFDKLFEASIEAGADDVTDEDEQYEVLTDPSAFHQVKTALEGAGFKAESAEITMIPQTMVKLEGKNAENMLKLMDRMEDNDDVQNVYANFDISEEEMEKMM
What are the official names of this protein?
Probable transcriptional regulatory protein GM21_0933.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADX_SHEEP
Sequence: SSSEDKVTVNFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFEQHIYEKLEAITDEENDMLDLAYGLTDRSRLGCQICLTKAMDNMTVRVPDAVSDARESIDMGMNSSKIE
What is the function of this protein?
Essential for the synthesis of various steroid hormones.  Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis.  Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.  Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons.
What are the official names of this protein?
Adrenodoxin, Adrenal ferredoxin, Ferredoxin-1.
What is the protein family that this protein belongs to?
Belongs to the adrenodoxin/putidaredoxin family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: 040R_IIV3
Sequence: MVTMAIKNFHIQDDRLKNGRGNKTMSESDYNTSDSGGWVLVRKKRDRSTRPPDVVDRWSNSTSTFPMGLDQIKIKRNGCVNTY
What are the official names of this protein?
Uncharacterized protein 040R.
Protein: RIMK_COXB1
Sequence: MKIAILSTKQELSSTQRLKEAALARGHKVKIINTLRCYMSLSQEKPTIHYMGKELARYDAVIPRIGASITFYGTAVVRQFEMMGTFCLNSSMSITRSRDKFRSLQFLSRKGIDLPITGFAHSPDDIEDLIQMVGGTPLIIKLIEGTQGIGVVLAETKKAAESVIQAFLGLKVNILIQEFIGETQGRDIRCFVIGNKVVATMQREARPGDFRSNVHRGGTTKLIKITPQEREISINAAKALGLNVAGVDLLRSKRGPLVLEVNSSPGLEGIENITKKDIAGMIIEFIEKNAKPIKAYSRYQG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: AROA_ALIF1
Sequence: MESLTLQPISKINGQINLPGSKSVSNRALLLAALASGTTKLTNLLDSDDIRHMLNALKALGVEYKLSANKTECEVTGLGRAFEPNEALELFLGNAGTAMRPLAAALCLGQGEFVLTGEPRMKERPIGHLVTALKAAGADVEYLENENYPPLKIKGTGLHGGTVEIDGSISSQFLTAFLMAAPLSTQETTIKIVGDLVSKPYIDITLDIMATFGVKIENQNYQTFVVPANQTYVAPGDFLVEGDASSASYFLAAAAIKGGEVKVTGIGKKSIQGDVQFADALAAMGTEIEWGDDYVIARKGELNAIDMDFNHIPDAAMTIATAALFAKGTTSIRNVYNWRVKETDRLAAMATELRKVGAVVEEGEDYITITPPASLQHASIDTYDDHRMAMCFSLVALSDTPVTINDPGCTSKTFPDYFDKLKELSC
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL1_SULAC
Sequence: MDFLNEIASKWQKVWDSERVYEADVDRTKEKKFITVAFPYTNSPLHIGHGRTYITADIYARYLRMKGYNVLFPFAFQFTGTPILSIADAVKRGDEEIISTFTNVYQIPIGVISKFSDPSYLSAYFKEDMRNTALTLGLSIDRRREFTTIDPAFERFVQWQYKRLQEIGYIKKEKAPVAYCPVDEFPVGMHDTRGDIEPEIIDLDVIYFQGEKLLFLTATSRPETIFGAVAILINPDSDYSIVVDNKNGKRLVMSTEAFKKLSFQMSLTEEERKKGGELIGLNVTNPVTLKKLTVLPSKYVESKQGTGVVMAVPAHEPLHYLALSELKESFEIVPVIKSEDYGDFPAMEVLETAQTTSAQELKDYIDTLYRIEFHKGSIRDEVVDLVPDYMKQFVGERIAGKSVREARSSVVELLRNLGVHGNIYEIINGPVYCRCGAEVVVKVFDDQWFIDYSNSTWKSSVLKSLDKIEILPQDAKREISKIIFNMKPRPFTRSRGLGVRLPWDDRQIIDSLSDSTIYTVFYIVANKVKSYPTSILNERFWDYVVLGRGDSSQLSRELGIPKEQLEELRMEVEYWYPVDSRHSGRDLVQNHIPYYLYHHVGVLGEDKVPKRIVLNGFIRVGGKKMSKSFGNVYPLNKAIREYGVDTVRLALTSTSSLSDDIEFSPNIAKSIGEQLKHIHDFIENLIKLQSVNEIRKVDLWISSLISEYIDLIDNCLSNLDLRTAYKTIYYDIYEDLKDYLELGNGKINSDIIKNVISVWIRLMAPFTPHLAEELWHKLDNSLVVRQRFPSKGELQYDKRALLEIEYLRYTIDLINSMKSKMSKEPETVIIYVNEDNTQRDLIRKAIESLKERKSLPDFEKEVGDREMARLAYEIAGDLPDKIKNLAEIGINESEILTSNAQFLLNKLDVKEIYIYNSKDPSTPDIKGKKSIALPYKPGIILT
What are the official names of this protein?
Leucine--tRNA ligase 1, Leucyl-tRNA synthetase 1, LeuRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HAS1_NEUCR
Sequence: MASEFSKKRKLKDAKIATEDGAATDKKTKKVKKDKKEKKAAEEVVEDATPEEENDAQKAEEQQDGDEVIPTGNGDKEDSDDKDAEAGDELTKTNDSLIAPSIATNATDFSELNLSDKTMKAIAEMGFTKMTEIQRRGIPPLLAGKDVLGAAKTGSGKTLAFLIPAIEMLSSLRFKPRNGTGAIVVTPTRELALQIFGVARELMKNHSQTYGVVIGGANRRAEAEKLGKGVNLLIATPGRLLDHLQNTPFVFKNMRSLIIDEADRILEIGFEDEMRQIIKILPKEDRQTMLFSATQTTKVEDLARISLRPGPLYVNVDEEKQFSTVEGLDQGYVVVDADKRFLLLFSFLKKMQKKKVIVFFSSCNSVKYYSELLQYIDLQVLDLHGKQKQQKRTNTFFEFCNAKQGTLICTDVAARGLDIPAVDWIVQFDPPDDPRDYIHRVGRTARGNNTKGRSLLFLQPNELGFLAHLKAAKVPVVEYDFPKSKILNVQSQLEKLIGQNYYLNQSAKDGYRSYLHAYASHSLRSVFDIHKLDLVKVAKSFGFSTPPRVDITLASSMSRDKKQTSRRAYGSQPKQNRH
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase has-1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HEM6_ECO5E
Sequence: MKPDAHQVKQFLLNLQDTICQQLTAVDGAEFVEDSWQREGGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGKDVYPRYKKWCDDYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTK_ENT38
Sequence: MQKYMLEARQLLALAIPVIIAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSILIMVVLWNAGYIIRSMDNIDPALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATAAVYWVMFFSMISYVKRARSMRDIRNEQRFSKPDMDVLKRLAQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVGYRLGQGSTLDAQTAARTGLGVGVCMAFCTALFTVTLREQIALLYNDNPEVITLASQLMLLAAIYQLSDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPTGYILALTDLVVDRMGPAGFWMGFIIGLTSAAILMMLRMRFLQRQPSSVILQRAAR
What is the function of this protein?
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
What are the official names of this protein?
Multidrug resistance protein MdtK, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MUTH_ECO55
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZFAS1_HUMAN
Sequence: MVPGPPESVVRFFLWFCFLLPPTRKASCDPRDLKSCNRPCVWSRLLKPNSSLSNLETAYFPQILRFLRPWYFSRSHLNYHQKAPARWEWLYSIYRKGTKAQRRNVLRSPCAPPQPSWPCSVI
What are the official names of this protein?
Uncharacterized protein ZNF22-AS1, ZNF22 antisense RNA 1.
What are the subcellular locations of this protein?
Secreted.
Protein: YFCF_ECOLI
Sequence: MSKPAITLWSDAHFFSPYVLSAWVALQEKGLSFHIKTIDLDSGEHLQPTWQGYGQTRRVPLLQIDDFELSESSAIAEYLEDRFAPPTWERIYPLDLENRARARQIQAWLRSDLMPIREERPTDVVFAGAKKAPLTAEGKASAEKLFAMAEHLLVLGQPNLFGEWCIADTDLALMINRLVLHGDEVPERLVDYATFQWQRASVQRFIALSAKQSG
What is the function of this protein?
Exhibits glutathione (GSH) S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB); however this activity is as low as 1% of that of GstA.  Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide.  Is involved in defense against oxidative stress, probably via its peroxidase activity.
What are the official names of this protein?
Glutathione S-transferase YfcF.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: EI3D1_DROME
Sequence: MSETINTAAQFPSFEKPTVQFNEKGWGPCELPDTFKDVPYQPFSKNDRLGKICDWTNTSNNDKKYQNKYASSFGTGIQYSYYHEEDETTFHLVDTARVQKPPHQRGRFRNMRNSRSGRGRNARGGLNTHGMTTLSGKNVKARDPRHGRGMGKKFGHRGPPPKMRESSVAVRADWASIEEMDFPRLIKLSLPNIKEGVDIVTCGTLEYYDKTYDRINVKNEKPLQKIDRIVHTVTTTDDPVIRRLSKTVGNVFATDAILATIMCSTRSNYSWDIVIEKVGDKVFMDKRDHTEFDLLTVNESSVEPPTDDDSSCNSPRNLAIEATFINHNFSQQVLKTGDQEPKYKFEESNPFISEDEDIQVASVGYRYKKWELGSDIVLVARCEHDGVLQTPSGEPQFMTIKALNEWDSKLANGVEWRQKLDTQRGAVLANELRNNACKLAKWTVQAVLAGSDQLKLGYVSRINPRDHSRHVILGTQQFKPHEFATQINLSMDNAWGILRCIIDLVMKQKDGKYLIMKDPNKPIIRLYDIPDNTFDSDDSDDGEGDDEGFQQVYNYAHNKI
What is the function of this protein?
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit D-1, eIF3d-1, Eukaryotic translation initiation factor 3 subunit 7-1, Eukaryotic translation initiation factor 3 subunit p66.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_BACAN
Sequence: MGQQVLKFSNEKMEKAVAAYSRELATVRAGRASASVLDKVQVDYYGAPTPVVQLANITVPEARLLVIQPYDKTSIGDIEKAILKADLGLNPSNDGTVIRIAFPALTEERRRDLVKVVKKYAEEAKVAVRNVRRDGNDDLKKLEKAGEITEDDLRGYTEDIQKETDKYIAKVDEIAKNKEKEIMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_HISSO
Sequence: YWIGPIGLAENESEGTDFHAVKNGYVSITPIQTDMTAYHSMTALQQWLDKE
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANF_PELRI
Sequence: APRSMRRSSDCFGSRIDRIGAQSGMGCGRF
What is the function of this protein?
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation.  Has a cGMP-stimulating activity (By similarity).
What are the official names of this protein?
Natriuretic peptides A.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAJ_POLSJ
Sequence: MAKKDYYDTLGVPKNASDDDIKKAYRKLAMKHHPDRNQGDKSKVSEEKFKEAKEAYEVLSDENKRMAYDQYGHAGVDPNMRGGGPGAEGFGGFAEAFGDIFGDVFGGQRGGQQRGGRQVYRGGDLSYAMEITLEEAAHGKEAQIRIPSWDDCNTCHGSGAKPGTKVVTCTTCHGHGVVQMRQGFFSVQQTCPQCKGTGKLIPEPCVACHGVGKTKNNKTLEVKIPAGIDDGMRIRSTGNGEPGTNGGPPGDLYIEIRIKKHEIFERDGDDLHCAVPISFTTAALGGEIEVPTLAGKAAIDIPEGTQAAKQFRLRGKGIKGVRSSYPGDLYCHITVETPVKLTEHQRKLLKELDESLKKGGARHSPSEEGWADKLKSFFSA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_ECO8A
Sequence: MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: GLNE_HAHCH
Sequence: MAAPSELQLYPSVIHPAIQKYWDEFCELPAETLSAFSSYYPDILRAFAVSDFLALNILREPELVLSFLQSSQHQKECQLVDFRAPLAEELSGALKEDDLLRILRLFRRRMMFRIIWRDLVCLVDYQVTTREVSWLAETCIDEALSWIYRDMSQQFGEPHSTAGVKQQLVVLAMGKLGANELNVSSDIDLIFTFPERGETQGGNRSLDNQAFFTRLGQRLIQALDNTTADGFVFRVDMRLRPYGQSGALALSFAAMEAYYQEQGRDWERYAMIKARAVAGDIDAGEELLTSLKPFVYRKYIDFGAVQALRAMKEMIEREVQRKGQDGNIKVGRGGIREIEFIVQVFQLMRGGRDVRLQQRNLLSTLECLEDEGLLPVAAAAELREAYIFLRNLEHAIQGLEDKQTQEIPKDEEGRERVAVAMGFPGWGACRVQLDKYRDCVSEHFADIIAERREAPLERPDTIEWKALWAGRLAQDEAQDLLLRSGCDQAQEIYEAVTQLRQSSRVQHMQLQGKERLDEFMPNLLQSLAQSRASHETCRRLLALVEAVLRRSAYLALLNENPGALTELIRLFAESAWIARQIVTTPLLLDELLHSGSLYTPPDTTALRDELRQQMLRIPNDDLEEQMEALRYFKKAHVLRVAASDLRETLPLMKVSDYLTFIAETIIEQVVDEAWETMVKKYGEPGYEDAALNDMRFAVIGYGKLGGIEMSYGSDLDLVFLHGASGDLSTSGETSIANQVFFTRLGQRIIHLLTTKTASGDIYEVDMRLRPSGNSGLLVSSVSAFQQYQEKSAWTWEHQALVRSRAVAGCPGIRAEFEKVRKDILTQHRDPAKLRTEVMDMREKMHASLGTKPDSSGSPPYFDLKHDRGGIVDIEFMVQYAALRWANEYPQIVVWSDNIRILEALGDAGVFSQEDADKLCDIYRLLRAHGHRLALQNLPARIQTDELLEERRWVVAFWEKVFAE
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: RL4_BORDL
Sequence: MERKVFSKDGQELRTIDLDDGVFNIDVSYGSIYNAINNELANLRVGTASTKTRAEVRGSSKKPWKQKGTGRARVGTRRNPVWVGGGIALGPKPRDYSYKLPKKVKRLAFKSVLSLCASVDDRLKVVENFTIDSGKTKELALIIKNFIKHNGRTVILLGNDDQMIKRAGKNIRDLKILSFNRLRVVDLFYTKNLIALESAINGLNELYVK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: Y912_METJA
Sequence: MVKSMIAVISDIHSNLEALNAVLNDIKNRGIKKIFCLGDIVGYGANPNECVELIRDLNCLSVVGNHDYGVLGKESLDYFNKYGAIAILWTKKVIKNENLKFLDSLPLIIEENIKGKKVIFSHANPKHPEIWEYLFPDYVDDVFNYGDLIFVGHSHIPFVNSEEGNLLLHEGKIYLDEDKKYLINPGSVGQPRDGINKASYCIFDEKDFKIEIVRVEYDIKKAYEKIVKNRLPEWLGERLFLGR
What are the official names of this protein?
Uncharacterized protein MJ0912.
Protein: RIMP_CAMJE
Sequence: MNLEALCKEAGLSFYDDELVSENGRKIYRIYVQKEGGVNLDDCARLSEILSPIFDVESPVNGEYFLEVSSPGLERKLSKIEHFAKSIGELVKITTNEKEKFEAKIIAVDDENITLENLENKEKTTINFNDIKKARTFVEW
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1519_METMJ
Sequence: MIREHFEFRQTITTILADDRGHIEAAKSGMLAARREVERQIAGDPYFSATLEPYTPNNPANVPASMARAAAEAGVGPMAAVAGAIARAGVEAMAGAGAAFGLVDNGGDIALVSNREVKIGIYAGASPLSGRFAFLIPPGEEILGICTSSATVGPSISFGTADAVTVFSPDVAAADAWATAICNRITADDTSVLDDLPKTGVLGVLAVIGDAVVRWGDLPPIVRARVDERLITAGSDWQYYGRS
What are the official names of this protein?
UPF0280 protein Memar_1519.
What is the protein family that this protein belongs to?
Belongs to the UPF0280 family.
Protein: RLME_NITEU
Sequence: MKSARTSRAWIKAHINDNFVRKANHEGYRSRAAYKLREIAEHDALFVPGMTVVDLGAVPGSWSQVALESVGPTGKVFALDMLDMQPLPGMTFIQGDFRENEVLAMLEAALGGKRADLVISDMSPNLTGIRVSDQAQGMYLAELALIFCREHLNPGKNFLVKVFQGSDFEAFRQMMQTDFSKVVIRKPKASRDRSKELYLLGLEKII
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLHL3_PONAB
Sequence: MEGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYVYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKGTRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron.  The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity).  The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).
What are the official names of this protein?
Kelch-like protein 3.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
Protein: PYRG_NITHX
Sequence: MARYIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNLDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTGRPATRQDNITTGRIYQDILTKERRGDYLGATIQVIPHVTNAIKDFILDGNDGYDFVLCEIGGTVGDIEGLPFFEAIRQIKNDLPRGHAVYVHLTLLPFIPSAGELKTKPTQHSVKELRSIGIQPDILLCRTDRTIPAEERRKLGLFCNVRESAVIEARDADNIYAVPEVYHAAGLDDEVLAAFGLEAPAPDLRSWHEINARVHNPEGQVTIAIVGKYTGMKDAYKSLIEALSHGGIANKVKVKLDWIESEVFENEDAAPFLEHVDGILVPGGFGQRGAEGKIKAAQFARERHVPYFGICFGMQMAVIEAARNLVGIPSANSTEFGPTSEPLVGLMTEWLRGNELEKRSRAGDLGGTMRLGAYPAALKRGSRVSGIYGGALEISERHRHRYEVNTAYKDRLEQHGLRFSGLSPDGVLPEIVEYEDHPWFIGVQYHPELKSRPFEPHPLFASFIQAAVVQSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: Y1057_VIBCH
Sequence: MDCRLGCGACCIAPSISSPIPGMPNGKPAGVRCVQLNEDNLCQLFGRPERPKVCHDFKACPVVCGKTNQQALANLTELERLT
What are the official names of this protein?
UPF0153 protein VC_1057.
What is the protein family that this protein belongs to?
Belongs to the UPF0153 family.