PharMolix/UniProtQA huggingface dataset:
Protein: CIAO1_DROMO
Sequence: MGRLILEHTLQGHKGRIWGVAWHPKGNSFASCGEDKAIRIWSLSGNTWTTKTILSDGHKRTIREVRWSPCGEYLASASFDATTAIWSKHECTATLEGHENEVKSVSWSRSGGLLATCSRDKSVWIWEVAGDDEFECAAVLNAHSQDVKRVVWHPTKEILASASYDNTIKMYAESALDSDWDCTATLSSHTSTVWSIDFDADGERLVSCSDDATLKIWRAYHPGNEAGIATPDKTTVWKCVCTLSGLHTRAIYDVSWCKLTGLIASACGDDAIRIFKESSDSKRDAPSFELLTSEESAHEQDVNAVEWNPVNVGQLISCSDDGTIKIWKLQE
What is the function of this protein?
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for the maturation of extramitochondrial Fe/S proteins.
What are the official names of this protein?
Probable cytosolic iron-sulfur protein assembly protein Ciao1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CIA1 family.
Protein: ASR1_YERPE
Sequence: MKTVLTLIVAATLSLFSVAFAADTVVPQTTPTATAPAPAVHNASAKTMHHKKAQKPNTIKNTHKTAPEQKAQAAQKHHKAAHSHKAPTVAPAAK
What is the function of this protein?
Required for growth and/or survival at acidic conditions.
What are the official names of this protein?
Acid shock protein 1.
What is the protein family that this protein belongs to?
Belongs to the Asr family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL22_BLOFL
Sequence: METIARYRYIRSSAQKIRLVANMIRKKEVVKAINILNYVNKKAALLVKKTLESAIANAEHNFGLNIDKLRVVKIFVDCGPSIKRVMPRAKGRSDRIVKRTSHLTIVVSD
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RH12_ORYSJ
Sequence: MHHPRARYPPGYTSGGGGGGGGGGGGGRGNGGGGFGGGGGGGGGNHGYYGRGPQPQPQQQHYHHQAQQLHQHQQQQQHAQRNSSSQQQQWLRRDQATAAAASGEVAARTAAQLEAVDSSSEDWKAQLNLPAPDTRYRTEDVTATKGNEFEDYFLKRELLMGIYEKGFERPSPIQEESIPIALTGSDILARAKNGTGKTAAFCIPALEKIDPEKNAIQVVILVPTRELALQTSQVCKELGKYLNIQVMVSTGGTSLKDDIMRLYQPVHLLVGTPGRILDLTRKGICVLKDCSMLVMDEADKLLAPEFQPSIEQLIHFLPANRQLLMFSATFPVTVKDFKEKYLPRPYVINLMDELTLKGITQYYAFVEERQKVHCLNTLFSKLQINQSIIFCNSVNRVELLAKKITELGYSCFYIHAKMLQDHRNRVFHDFRNGACRNLVCTDLFTRGIDIQAVNVVINFDFPKTSETYLHRVGRSGRFGHLGLAVNLITYEDRFNLYRIEQELGTEIKTIPPQIDLAVYCQ
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping.
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 12.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Protein: G6PI1_NEIG1
Sequence: MKHLHDLPAWSKLWNHFDDSKTLHMREMFEQDPQRAERYWLQVGGLTLDYSKNRINDETMSLLFELAREAGVPERMRQMFHGEKINTTENRAVLHVALRNRTNSPIMVDGEDVMPKVNRVLQRMGEFAHEVRSGSWLGYTNQVITDVVNIGIGGSDLGPLTMCTALKPFGHPRLNMHFVSNVDGSQLRDVLSKVHPETTLFIIASKTFTTQETLTNALTAREWFLNHAGDEEAVAKHFAAVSTNRKAVAEFGIDIANMFEFWDWVGGRYSLWSAIGLPIMLYLGEENFIEMLNGAHLMDQHFINTPLERNLPVILALIGIWYINYYGGGSHVIAPYDQHLHRLPKFIQQLDMESNGKQVTLDGKAVGHETSPIIWGETGINGQHAFFQLLHQGTHITPIDLIASLEKRSNLPGHHEILLANVFAQAEAFMCGKTPDEVRAELKAQGMDEARIEELVPHKTFSGNRPTNLILMDKVNPRNMGSLIAMYEHKTFVQGIIWGINSFDQWGVELGKQLAKTILGELTGETEPQKHDSSTERLINLYLQTNRK
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase 1, GPI 1, Phosphoglucose isomerase 1, PGI 1, Phosphohexose isomerase 1, PHI 1.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_PSESM
Sequence: MPKMKTKSGAAKRFLKTANGIKHKHAFKSHILTKMSTKRKRQLRGSSLLHPSDVAKVERMLRLR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: YQGF_LEGPH
Sequence: MPRGVYLGFDFGYKRIGVAVGQRLTCSASPLSTIEAKAGIPDWNTIQKVITQWNPQALIVGLPTCIDDRELYTTSAARRFAKQLHKRFSLPVHLVDERLSTVEARGYLFEQGGYRQIKKAEVDSIAACVILEQWLQQSE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BBS2_CAEEL
Sequence: MDGDRTPEEQIEIAESDQGPQLDDNVELANVFSYSLDQRIMEGCVISAILEPRGLETIVAVSVTNKIIIKDKETSLNITETIRCIAAAPFGDGYDCIIIGTDSSVICYDVHNNLTVFRNDVPDGVSCFVYGKLGELDEAIYCGGNCCIWGFDKTGANTYWTVTGDQVTTMCLSDYDNDGETELVIGSPDFEIRVFKNDLMRTELMETDEITCLAHVANGCFAYSLNNGTIGTYVLKERQWRIKSKSNVSKIFNFEEEGLMVVVWKQGKVDLRFAHNGEVLSRDSVSSHVASASVSKKGDESFITVVCLDGKVKGFKIQRAQNGSIDKTQQLIREFGQKKHNLMMELSNYEQEEQLADVEKDRDFRIPVDTEVAVVFVVNTELQLLSLRVEASHNIPIRGVLIFAEGLFEGESYIWIPPNEYQSRSVIDIPLVIDKDSTNDLHTKVFLGQVDSNKLMVMENTRILPKFCRFTLLREEYSKFFYMPTAYIQFDINSRAAKLSEWVQESFTIDASLVEMFDEPEGEFKFMGLRPKHEKSLMFKISHSEKTCKIYHDKIETMGAIVQSYASFYQIQNMESVAHFPDVFKEADEILEEIDPMTEVRDRLTAELQERQAAVKEIIIRAEDSIAIDNIPDARKFYIRLKANDAAARQAAQLRWNNQERCVKSLRRLNKIIENCSRLRVGEPGRQIVVSCRSAIADDNKQIITKILQYGASV
What is the function of this protein?
Component of the BBSome complex (By similarity).  The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity).  Required for proper BBSome complex assembly and its ciliary localization (PubMed:22922713).  Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:15231740, PubMed:22022287, PubMed:22922713).
What are the official names of this protein?
Bardet-Biedl syndrome 2 protein homolog.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.
Protein: MNMA_STRM5
Sequence: MSTPRVMVGVSGGVDSSVAAWRLVQQGEAVAGLFMQNWADDGSGECRAEDDRRDAVAVCGLLGIPFHFRDFSNEYWQGVFEHFLAEYAAGRTPNPDVLCNREVKFKHFLDAARELGAERIATGHYARVAQRGHQWLLLRGADRSKDQSYFLHQLGQQQLAATLFPIGDLEKTDLRRIARDVSLPTHAKKDSTGICFIGERDFREFLGRYLPAKPGQILDPADGSVIAEHPGVFYFTLGQREGLNIGGVRGRPAAPWYVVGKDVASNVLYVDQDRDSTWMLSNRLRSETAHWIAGAPPARRFECTAQTRYRQPDEPCTVEVLDDGSVLVTFARPQRAVTPGQSLVLYDGDVCLGGAVIAATDAPLEQRLRTTPSPFEVIAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AACA_STAEQ
Sequence: MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLESLKKHYTEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQFIGEPNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKSGFRIIEDLPEHELHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD
What is the function of this protein?
Involved in resistance to gentamicin, tobramycin, and kanamycin.  Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region.  The C-terminal region is a kinase that phosphorylates several 4,6-disubstituted aminoglycosides.
What are the official names of this protein?
Bifunctional AAC/APH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the aminoglycoside phosphotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M17L2_HUMAN
Sequence: MARGGWRRLRRLLSAGQLLFQGRALLVTNTLGCGALMAAGDGVRQSWEIRARPGQVFDPRRSASMFAVGCSMGPFLHYWYLSLDRLFPASGLRGFPNVLKKVLVDQLVASPLLGVWYFLGLGCLEGQTVGESCQELREKFWEFYKADWCVWPAAQFVNFLFVPPQFRVTYINGLTLGWDTYLSYLKYRSPVPLTPPGCVALDTRAD
What is the function of this protein?
Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607).  Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607).
What are the official names of this protein?
Mpv17-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal membrane protein PXMP2/4 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane.
Protein: SERC_YERPP
Sequence: MTQVYNFSAGPAMLPVEVLRRAEQELRNWHGLGTSVMEISHRSKEFMQVAEESEKDLRDLLQIPANYKVLFCHGGARAQFAAVPLNLLGDRNSADYIDGGYWAHSAIKEAQKYCTPNVIDVTTHDNGLTGIQPMKQWKLSDNAAYVHYCPNETIDGVAINEQPDFGNKVVVADYSSSILSRPIDISRYGVIYAGAQKNIGPAGLTLVIVREDLLGKAHTALPSILDYKVLADNDSMFNTPPTFAWYLSGLVFKWLKEQGGLCEMEKRNQAKAELLYGAIDRTGFYRNQVAITNRSWMNVPFQMADASLDKLFLREAEAQGLQALKGHRVAGGMRASIYNAMPIEGVKALTDFMADFERRHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHJ_NASOF
Sequence: MQGTLSVWLAKRGLVHRSLGFDYQGIETLQIKPEDWDSIAVILYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEYGVNQAEEVCIKVFTHRSNPRIPSVFWVWKSTDFQERESYDMLGITYDSHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAY
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: YPFN_SHIB3
Sequence: MDWLAKYWWILVIVFLVGVLLNVIKDLKRVDHKKFLANKPELPPHRDFNDKWDDDDDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: DCTA_SALEP
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHYYPELGAQMKPLGDAFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAQAVAVYAAQAKEQGIIAFLMDVIPGSVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGSLVQLGQLIICFYITCILFVVVVLGTIARVTGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSHMDIFHQITLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATVVVAKWVKELDHQKLDDVLNNRAPDGKTHEISS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GPC1_CHICK
Sequence: MRFFPWGFWLLCVASAPARGDSGSKARSCAEVRQLYGAKGFSLNGVPQAEISGEHLRICPQGYTCCTSEMEENFANKSRSEFEAMMKEAGRSVQTILTAQYKSFDNYFQDLLNKSEKALYDTFPSLYGDLYTQNMKVFKDLYSELRRYYRGSNINLEEALNEFWTRLLERLFKLMNAQYHITDEYLDCMVKHAEQHKPFGEVPRDLKVKATRAFIVARSYAQGFLVGSDVVKKVSQVSLSHECTRAVMKLMYCPHCRGMASVKPCSNYCLNVVKGCLANQADLNTEWKYLMDALVAVADRIDGPYNVDTVIGTIHMRISEAISNLQENKVSITAKVFQGCGNPKVSMKGSSSEDKKRRGKVTLEAKSSAVALEMLVLDAKGNLTALKSYWVTLPGVLCSKKIMASPAEDDKCWNGMTKGSYLPEVMGGGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLGNANIGNDVDFQDASDDMSGSGSGDSCPDDVCVKRLSKSPSTRQPETHAIPKQSGHGVIGASSRSLPSAFLLFLSGASIVVQHLWR
What is the function of this protein?
Cell surface proteoglycan that bears heparan sulfate.  Modulates Wnt-signaling pathway.
What are the official names of this protein?
Glypican-1, Heparan sulfate proteoglycan core protein.
What is the protein family that this protein belongs to?
Belongs to the glypican family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. Endosome. SUBCELLULAR LOCATION: [Secreted glypican-1]: Secreted, extracellular space.
Protein: RRP3_MESVI
Sequence: MNIFIKQNSSTVKRRYPLQKFVLKFLWLEKNLAVTVDQVTNRGNSPITEYFFWPRKDAWEELKDALANKPWISYDESIALLNQTTDVINYWQEDEKKPSLSEAQAKFPNCIFTDKFANCLYEN
What is the function of this protein?
Probably a ribosomal protein or a ribosome-associated protein.
What are the official names of this protein?
Probable 30S ribosomal protein 3, chloroplastic, PSRP-3.
What is the protein family that this protein belongs to?
Belongs to the chloroplast-specific ribosomal protein cS23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ALLA_ECO55
Sequence: MKLQVLPLSQEAFSAYGDVIETQQRDFFHINNGLVERYHDLALVEILEQDRTLISINRAQPANLPLTIYELERHPLGTQAFIPMKGEVFVVVVALGDDKPDLSTLRAFITNGEQGVNYHRNVWHHPLFAWQRVTDFLTIDRGGSDNCDVESIPEQELCFA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the anaerobic utilization of allantoin as sole nitrogen source.  Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: Y2578_YERPN
Sequence: MDHRLLEIVACPVCNGKLYFNKENLELVCKVDNLAYPVRDGIPVLLENEARPLSIDEKHA
What are the official names of this protein?
UPF0434 protein YPN_2578.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: HIS1_BUCAP
Sequence: MFNTNRVRIAMQKTGRLSSESIKLLTCCGIKINLKQQKLIAFAENMPIDVMLVRDDDIPGLVMDGVVDLGIVGENVLQEELLHRISQNLENSYITLRRLDFGICRLSLAIPINTPYVDITSLKNFRIATSYPHLLKKYLDSKNIVFKSCMLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVQVVFRSHACLICKTGNINFAKKEVINKLMTRIKGVIKARESKYIMLHAPVNKLEEVISLLHGAEKPTILKLAGDDHRVAMHMVSSETLFWETMEKLKSLGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHO1_MOUSE
Sequence: MNFNVWNVKEMLSIPSGSGITKPSNWNNNQTDCSLSDSQFLFGSQFCPENSETLLPSLDAGACLRHPKQTQQNSVDSEPSIFIKYQAKPQLLGGDTKDESLFSLPLPVGKSKGLSKQFEEKKRRATDQSDSETLHSFVSHFPEVINKLQTSVEKTEENLSSRSQSILDSVETIAKTFQETARVQHDLMVESVRDKGSMEQAILEIQRTCAARQAEFMEMKSTLKNLEVLVVEQTKNLQQFCDNLSQLIVPGILEELKKFTSVPQVAGHLKDSTSQTSPSLTQSLHFTRQEKHPSEEPATWQAQEAPAGNPSTSSQRPGECGVWDEGAESGVFQKAALPTDGLHRGDGHVKNKTVPTYCKNWVMTTRSVSNHFSNLPSQRAGNGQGLMAQGASQRDVSKFEARVKNACPEYGPQSMCSFDSLEQSATEQKGRPCRKRRRGKKQQPQRSKRGGLLDRKQGQTSKAACAFIARHHCPQSPVCDPQGPLICWLTPRSSTKSTCHILGGTGETSQTARAAQGNLVQHSQRSSTDSSSQGDQQINWFSDLSLENLEPPQCKKGGTNLLCDPDFDSSDDNF
What is the function of this protein?
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:27723721).  Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721).  Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance (PubMed:27723721).
What are the official names of this protein?
Interactor of HORMAD1 protein 1, Coiled-coil domain-containing protein 36.
What are the subcellular locations of this protein?
Chromosome. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis (PubMed:27723721). Appears on chromatin during preleptotene, when pre-meiotic replication occurs and axes have not yet developed (PubMed:27723721). Remains associated with unsynapsed axesn zygotene, when axes elongate and synapsis begins but disappears from synapsed axes (PubMed:27723721). Localization diverges in the two sexes beyond zygotene (PubMed:27723721). In spermatocytes, synapsis between the largely non-homologous X and Y chromosomes is mostly constrained to their short pseudoautosomal regions (PARs) (PubMed:27723721). At the zygotene-to-pachytene transition, high levels remain on unsynapsed sex chromosome axes but also on PARs (PubMed:27723721). However, by early pachytene disappears from both the synapsed and unsynapsed regions of sex chromosomes (PubMed:27723721). Reaccumulates on unsynapsed axes of sex chromosomes in mid-late pachytene and on desynapsing autosome axes in diplotene, but disappears from chromatin concomitant with axis disassembly after diplotene (PubMed:27723721). In oocytes, disappears from axes after all chromosomes synapsed and is undetectable on chromatin beyond zygotene (PubMed:27723721). Ovarian levels also dramatically decrease as oocytes progress to late prophase (PubMed:27723721). HORMAD1 is required for robust accumulation on chromatin and unsynapsed axes, suggesting that HORMAD1 recruits IHO1 to unsynapsed axes (PubMed:27723721).
Protein: RL11_SERP5
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSVEKGLPIPVVITVYSDRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKVTSAQVREIAETKAADMTGSNVEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: AQP8_NOTAL
Sequence: MSGETPMCSIDLSEVKAKETRMAGRFRVSWYEQYIQPCVVELLGSALFIFIGCLSVIENSPDTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTVIGGLKTMLLIPYWISQIFGGLIGAALAKVVSPEERFWNASGAAFAIVQEQEQVTEALGVEIILTILLVLAVCMGAVNEKTMGPLAPFSIGFSVIVDILAGGGISGACMNPARAFGPAVVAGYWDFHWIYWLGPLLAGLFVGLLIRLFIGDEKTRLILKSR
What is the function of this protein?
Channel that allows the facilitated permeation of water and uncharged molecules, such as hydrogen peroxide and the neutral form of ammonia (NH3), through cellular membranes such as plasma membrane, inner mitochondrial membrane and endoplasmic reticulum membrane of several tissues.  The transport of ammonia neutral form induces a parallel transport of proton, at alkaline pH when the concentration of ammonia is high.  However, it is unclear whether the transport of proton takes place via the aquaporin or via an endogenous pathway.  Also, may transport ammonia analogs such as formamide and methylamine, a transport favourited at basic pH due to the increase of unprotonated (neutral) form, which is expected to favor diffusion.  Does not transport urea or glycerol.  The water transport mechanism is mercury- and copper-sensitive and passive in response to osmotic driving forces (By similarity).  At the canicular plasma membrane, mediates the osmotic transport of water toward the bile canaliculus and facilitates the cAMP-induced bile canalicular water secretion, a process involved in bile formation (By similarity).  In addition, mediates the hydrogen peroxide release from hepatocyte mitochondria that modulates the SREBF2-mediated cholesterol synthesis and facilitates the mitochondrial ammonia uptake which is metabolized into urea, mainly under glucagon stimulation (By similarity).  In B cells, transports the CYBB-generated hydrogen peroxide from the external leaflet of the plasma membrane to the cytosol to promote B cell activation and differentiation for signal amplification (By similarity).  In the small intestine and colon system, mediates water transport through mitochondria and apical membrane of epithelial cells (By similarity).  May play an important role in the adaptive response of proximal tubule cells to acidosis possibly facilitating mitochondrial ammonia transport (By similarity).
What are the official names of this protein?
Aquaporin-8, AQP-8.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS6_OLEA2
Sequence: MRKFETLLLLSPELGSQPREDLLAVLTGVIEREQGSVLAVDHWGMRDLAYPVRKHMRGYYVRLEYAVAGPSVAELERIIRITDGIYKFVTVKLADEAEEAA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: CYSD_AGRFC
Sequence: MSNAVHETDSKNTVASKPPLDPHLKALENEAIHIFREVAAEFDNPVMLYSIGKDSSVLLHLARKAFFPGRIPFPLLHVNTGWKFKEMIEFRDNIVKEYDLDLISYTNPRGALENVTPFSHGSALYTDIMKTEALRQALDAGQFDAAFGGARRDEEASRAKERIYSFRTPDHKWDPRNQRPELWNIYNGMVRKGESVRAFPLSNWTEVDIWRYIEAENIPLVPLYYAAERPYIERDGMMILAEDERLELLPGEEIKHGSIRFRTLGCFPLTGAIRSEAATLQDVIAELEIATVSERQGRAIDRDQSGSMEKKKREGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: MNMG_CALS8
Sequence: MEFVAGEYDIVVVGAGHAGCEAALACARLGLKTIVFAINLDSIGNMPCNPSIGGTGKGHLVREIDALGGEMGKAADATAIQVRILNRAKGPAVYSLRAQCDRARYKLYMKRVLESQPNLDIRQGEVCDILVEDGKVTGVKLTTGAIFRAKAVVLATGTFLGGRIIIGETVYDGGPDGMHPAKYLTESLKKLGIEMMRFKTGTPARVHRRSLDFSKMQIQLGDEVITPFSFEHETLEIEQVPCYLTYTTEETHRIIRENLHRAPLFTGLIQGVGPRYCPSIEDKVVRFADKPRHQVFIEPMGRDTEEMYVQGMSSSLPEDVQIKMYRSVIGLENVQIMRPAYAIEYDCINPLQLEATLQFKKIKGLFSAGQINGTSGYEEAAAQGIIAGINAAMYVKGKEMLVLDRSQAYIGVLIDDLVTKGTNEPYRIMTSRAEYRLILRQDNADLRLTEIGYRIGLISQERYEKFLKKKKMIEDEIERLKKTVIAPSDKVNKFLIEHGSSPISTGVKLSELLKRPELSYEALREIDPQRPDLPRSVKEEVEIEIKYEGYIKKQLQQIEQFKKLENKKIPEWVDYNQISGLSTEAKQKLSQIRPASIGQASRISGVSPADISVLLIWLEQAKKGSK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.