PharMolix/UniProtQA huggingface dataset:
Protein: PLS1_RAT
Sequence: MEKHGPPEHAAYPIPQADYQGSQGPYPGPQGPYPGPQGPYAGPQGPYPGPQGPYAGPQGPYPGPQPGYPVPPGSYAGGDPSGFPVQHQPAYNHPGGPGGTPWMQAPPPPLDCPPGLEYLTQIDQILVHQQIELLEVLTGFETNNKYEIKNSLGQRVYFAVEDTDCCTRNCCGASRPFTLRILDNMGREVMTLERPLRCSSCCFPCCLQEIEIQAPPGVPVGYVIQTWHPCLPKFTLQNEKRQDVLKVVGPCVVCSCCSDIDFELKSLDEESVVGKISKQWSGFVREAFTDADNFGIQFPLDLDVKMKAVMLGACFLIDFMFFERTGNEEQRSGVW
What is the function of this protein?
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (By similarity).  Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity).  Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity).  Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (By similarity).  May contribute to cytokine-regulated cell proliferation and differentiation (By similarity).
What are the official names of this protein?
Phospholipid scramblase 1, PL scramblase 1, Ca(2+)-dependent phospholipid scramblase 1, Mg(2+)-dependent nuclease.
What is the protein family that this protein belongs to?
Belongs to the phospholipid scramblase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the perinuclear region in the presence of RELT. Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.
Protein: Y6020_BACC1
Sequence: MSTILVLGGSNGRTLEKLAKKRDCQVIFHDGKNHGGVKKTFRSVIKKCDVIVVQKGACGHVSIDVAKEYAKKYDVPLLFNQGFGGTGALEIGLKHLQVA
What are the official names of this protein?
UPF0751 protein BCE_A0020.
What is the protein family that this protein belongs to?
Belongs to the UPF0751 family.
Protein: PAH2_ARATH
Sequence: MNAVGRIGSYIYRGVGTVSGPFHPFGGAIDIIVVEQPDGTFKSSPWYVRFGKFQGVLKNGRNLIRIDVNGVDSGFNMYLAHTGQAYFLREVEDVVGESESGEVYTLSSGDEAETTSRDDVVDKVKIPLKSRSCNYDSPSPRTGNGKIVGKPGILGYVFGGRSVRESQDCGVERAEIAADLLEVKWSTNIDTRKRGKGMSSESLDGKDYGESTSTSGKSCVEGSSEMLVDSDSILETPLVASPTLRFLDEKEQDFRESTNVEDYCEEDGSSGVVVENGLCEASSMVFSVTSEGSGNVEIFVEPRTEALAEDAVSGSDLDSKQELLRAPESVEIATLGSADQADMGSIGTSQEGSSTGSPVQDENKITIKDMHISAGDFEKSQSASGESILQPEIEEEQFSFSDLDECKPGGNSSVGSSSSDTVKVDGKESYDETKTSPEKGVENTMALSEPINIERKKDIFTDEMERLVGSLPIMRLQNNDDMDASPSQPLSQSFDPCFNTSKLDLREDESSSGGLDAESVAESSPKLKAFKHVIANPEVVELSLCKHLLSEGMGAEAASQAFNSEKLDMEKFASLGPSILENDKLVVKIGGCYFPWDAAAPIILGVVSFGTAQVFEPKGMIAVDRNEKPGDVLAQGSGSWKLWPFSLRRSTKEAEASPSGDTAEPEEKQEKSSPRPMKKTVRALTPTSEQLASLDLKDGMNSVTFTFSTNIVGTQQVDARIYLWKWNSRIVVSDVDGTITRSDVLGQFMPLVGIDWSQTGVTHLFSAVKENGYQLIFLSARAISQASVTRQFLVNLKQDGKALPDGPVVISPDGLFPSLFREVIRRAPHEFKIACLEEIRGLFPPEHNPFYAGFGNRDTDEISYLKVGIPRGKIFIINPKGEVAVNRRIDTRSYTNLHTLVNRMFPATSSSEPEDFNTWNFWKLPPPSLM
What is the function of this protein?
Magnesium-dependent phosphatidate phosphatase which catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol.  Acts redundantly with PAH1 to repress phospholipid biosynthesis at the endoplasmic reticulum (ER).  May function indirectly as repressor of multiple enzymes involved in phospholipid biosynthesis.  Is involved in the pathway of galactolipid synthesis in the ER, which is required for the membrane lipid remodeling, an essential adaptation mechanism to cope with phosphate starvation.
What are the official names of this protein?
Phosphatidate phosphatase PAH2, Phosphatidic acid phosphohydrolase 2, AtPAH2.
What is the protein family that this protein belongs to?
Belongs to the lipin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RHDF2_MOUSE
Sequence: MASADKNGSNLPSVSGSRLQSRKPPNLSITIPPPESQAPGEQDSMLPERRKNPAYLKSVSLQEPRGRWQEGAEKRPGFRRQASLSQSIRKSTAQWFGVSGDWEGKRQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPKIVDPLARGRAFRHPDEVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLPRRKRISVAHMSFQAAAALLKGRSVLDATGQRCRHVKRSFAYPSFLEEDAVDGADTFDSSFFSKEEMSSMPDDVFESPPLSASYFRGVPHSASPVSPDGVHIPLKEYSGGRALGPGTQRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHIIITLLVICTYGIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKDQQIEQLVRRERDIERTSGCCVQNDRSGCIQTLKKDCSETLATFVKWQNDTGPSDKSDLSQKQPSAVVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAQSNHTGLLHIDCKIKGRPCCIGTKGSCEITTREYCEFMHGYFHEDATLCSQVHCLDKVCGLLPFLNPEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPWIDNIAHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVLWLYIYPINWPWIEYLTCFPFTSRFCEKYELDQVLH
What is the function of this protein?
Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation.  Does not exhibit any protease activity on its own.
What are the official names of this protein?
Inactive rhomboid protein 2, iRhom2, Rhomboid family member 2, Rhomboid veinlet-like protein 6, Rhomboid-related protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS21_STRP4
Sequence: MSKTVVRKNESLDDALRRFKRAVTKAGTLQETRKREFYEKPSVKRKRKSEVARKRKKF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: SECD_ALIAD
Sequence: MKWGRLLAFLAMVVVVLGLTISTGPKIWKSIPLGLDLKGGVDLLYAVDTPKGHPLDSTGKAALVRAIEMRVNSLGVSSPIIQLEGRNQLGQDQIRVEVAGVKNQQEAVSVIGATAQLAIYGSAKIDPKTGKIVPVGPPLATGADLKSNAHWVVDQQTGQNAVAIEFKNASLWTSITKRYLQKPIYVFLNGQLLTNPVVEQVMYTGQSEISGGNLTTPQACIDLANELNAGALPYPLTLESETSVGPTLGATSLHRTLIAGVIAVVLIFAFMIAAYRMAGLIADIALVAYGYLTLLTFAGLHVVLTLSGLAALILGVGIAVDANIITYERIKDEVRNGRSLRSAVRIGNKNAFRTIVDSNATTFIAGLIMYIFGGEGDVRGFAVALMVGIIVSLLTAVLFARAMLLTFTAAQAVKNPWWYGAPRGVVKSREAKV
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TYW1_ARATH
Sequence: MSTTSSVRVRLAFVALLSATTFYCIHKYRRLKHLKNLSLNPSSTLKASRGKIFFISQTGTAKALAQRLHELCASNDIAFDIVDPHSYEPEDLPKETLVLFIASTWDGGKPPKNGEFLVNWLGESAEDFRVGSLLLSDCKFAVFGVGSRAYGESYNAVAKELSSRMIGLGGLEMIPVGEGDVDDGELDRAFQDWCDGVIRVLKGGSAQETNGVSQQIGAVEDDLEYYDSTDEEDEDNDADGGIVDLEDIAGKAPSKRNGVVKVTKVDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDEPSVIVKGALDLHKNMIKQMKGVPGVTPEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGRRISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHTDVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTEKFKVDGKWFTWIDYEKFHDLVASGEPFTSTDYMAQTPSWAVYGAQEGGFDPGQLRYKKERNHPPKPQAVLA
What is the function of this protein?
Probable component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.  Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).
What are the official names of this protein?
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, tRNA wybutosine-synthesizing protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TYW1 family.
Protein: BCA1_CAEBR
Sequence: MNRIIRGVIQYNQKIKAGLVKQFEHVSDHPNPTAVMFTCMDSRMLPTRFTQSAVGDMFVVRNAGNMIPAAPNYGSYSEVSINTEPAALELAVKRGKIRHVVVCGHSDCKAMNTLYQLHQCPTKFDVSSPMDQWLRRNGFESMKKLNERLHIGPKTMKFESEVAPSQSFEAIIDPMEKWSAEDKLSQINVLQQIMNISTHEFLKDYLEAGNLHLHGAWFNIYDGEVFLFSKDRKRFVVIDEKTVPSLSAELERRCPLPEDKAGDVVIQNLH
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Beta carbonic anhydrase 1.
What is the protein family that this protein belongs to?
Belongs to the beta-class carbonic anhydrase family.
Protein: PXPA_RHOPA
Sequence: MKIDLNCDLGEGFGVWQMGDDAAMMQIATSVNIACGFHAGDPDIMHATVKLAKQNGVAIGAHPGFRDLHGFGRRPVPGITAAEIENLVAYQIGALQAVAALAGHKVTHVKAHGALSNVACEDDMTARAIASAIKAVDPSLVFVVLANSKLMLAGEAAGLPLAHEVFADRAYEDDGNLVSRKKPGAVLHDPNEIAERVLRMAQDGAVVSVTGKVIKMRTDTVCIHGDTKGAVEIARGVRRKLEASGITVAPFAGT
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: METK_MAIZE
Sequence: RPEEIGAGDQGHMFG
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
Probable S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase, MAT, Spot 178.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_CAEEL
Sequence: MFVALGAQIYRQYFGRRGMAMANNSSVANKVCLIVIDGWGVSEDPYGNAILNAQTPVMDKLCSGNWAQIEAHGLHVGLPEGLMGNSEVGHLNIGAGRVIYQDIVRINLAVKNNKFVTNESLVDACDRAKNGNGRLHLAGLVSDGGVHSHIDHMFALVKAIKELGVPELYLHFYGDGRDTSPNSGVGFLEQTLEFLEKTTGYGKLATVVGRYYAMDRDNRWERINVAYEAMIGGVGETSDEAGVVEVVRKRYAADETDEFLKPIILQGEKGRVQNDDTIIFFDYRADRMREISAAMGMDRYKDCNSKLAHPSNLQVYGMTQYKAEFPFKSLFPPASNKNVLAEWLAEQKVSQFHCAETEKYAHVTFFFNGGLEKQFEGEERCLVPSPKVATYDLQPEMSAAGVADKMIEQLEAGTHPFIMCNFAPPDMVGHTGVYEAAVKACEATDIAIGRIYEATQKHGYSLMVTADHGNAEKMKAPDGGKHTAHTCYRVPLTLSHPGFKFVDPADRHPALCDVAPTVLAIMGLPQPAEMTGVSIVQKI
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, iPGM, Cofactor-independent phosphoglycerate mutase homolog.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: RNP4_METMJ
Sequence: MADTTRKSGSRRLARERIAVLFARAAEFYPESPDRSNRCVELARKIGMRHRIRIERPLKRRFCRRCYTYLVPGSNARVRVHRGRVVVTCLACGHRSRFPVGRPRQ
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 4, RNase P component 4, Rpp21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAMB_MARAH
Sequence: MPVLRDRIPRRGFFLGLALLAALSGCSSTDTFEQPVPVPEIEASVEFERVWSMSVGDGHDGDFLYLAPLVTGDLIYAASADGELYAVATETGEVAWESEFEDRIFSGLGGDGQNLYLTTENADLVALSREDGSEVWRTSLPTEVLSSPQSNGSLVVAQTTDGKVLGFSATDGEKLWQYDGSVPVLSMRAAAAPLVGGDVVIASFASGKLIALTAASGQPMWQYEVGQPQGRTELERLVDVTGQPLVIETAVMVVGYQGKLALVDIRTGQEIWSRKASSLYSPMIGGGQIYLAAADGEIIALRGSDRREVWTQDRLAWRQLTQPMVYEDYLVVGDFEGYLHALDREDGSLVGQREFDDEGIRVPAQRLANGNLLVFGNSGKMAVFQVKPQD
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamB.
What is the protein family that this protein belongs to?
Belongs to the BamB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: SYH_BURCH
Sequence: MTEQKRKIEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFTDALNGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLTGIKLEINSLGLAEERAAHRVELIKYLEQFADVLDEDAKRRLYTNPLRVLDTKNPALQDIAQNAPKLIDFLGDESRAHFEGLQRLLLANNIPFKINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGIERILELLKEEDLAPEQEGVDVYVVHQGDTAREQAFIAAERLRDTGLDVIFHCSADGAPASFKSQMKRADASGAAFAVIFGEEEVANGTVGVKALRGAGAEGEKNVQQTVPVESLTEFLINAMVASAEDGDD
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NODC_RHIS3
Sequence: MDLLTTTSTVAVACYALLSTVYKGMQAVYSLPPTVAPASEDLVGSDLWPSVDVIIPCYNEGPLTLSACLDSIANQEYAGKLRVYVVDDGSGNRDAVIPIHDNYAGDPRFDFILLPENVGKRKAQIAAIRRSSGDLVLNVDSDTTLASDVIRKLARKMQDPAIGAAMGQLTASNRSDTWLTRLIDMEYWLACNEERAAQARFGAVMCCCGPCAMYRRSSLLSLLDQYETQMFRGKPSDFGEDRHLTILMLEAGFRTEYVPDAIAVTVVPDRLGPYLRQQLRWARSTFRDTLLALRLLPGLDRYLTLDVVGQNLGPLLLALSVIAGIAQFALTATLPWPTILVIAAMTIIRCTVTACRARQARFIGFSLHTFINIFLLLPLKAYALCTLSNSDWLSRKTATLPNADKKQIIVANPIAGVGTGSSGSAEAIRRTDLPRDSSKLVNADSVCSAE
What is the function of this protein?
Involved in the synthesis of Nod factor, a sulfated N-acyl-beta-1,4-tetrasaccharide of N-acetylglucosamine which initiates a series of events in the host plant species leading eventually to nodulation.
What are the official names of this protein?
N-acetylglucosaminyltransferase, Nodulation protein C.
What is the protein family that this protein belongs to?
Belongs to the NodC/HAS family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PYRF_BACC3
Sequence: MSQSLIVALDFPGKQDVEQFLRHFEGEELFVKVGMELFYKEGPAIITYLKEKGHKIFLDLKLHDIPNTVKSAMRSLASLDVDMVNVHAAGGSSMMKAAIEGLEEGKQEGKERPICIAVTQLTSTSEAMMKKEIGIEKTLEEAVAHYAKLTKESGLDGVVCSTLEVPKLREVCGNEFVTVTPGIRLASDDVNDQVRVATPKRARELGSSYIVVGRSITKAENPLEAYKTVKQQWEGVTV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: ACPS_BORBZ
Sequence: MKSIGCDIIKVERFKNFLENKKKMERFFTHKEIENFKLKGGSIIESLAGKFAAKESLIKALSPLLQYKINYTLKDIEVIKSLKGNAEFCLHNEVEKFAIKMNLKLYLTISHEKEYAIAFVIVEN
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_CLOBB
Sequence: MFIDKAKVFIKSGKGGDGAISFRREKYVPLGGPNGGDGGDGGDIILQVDTGITTLLDFKYKKKFIAEDGENGGASKCYGRAGQDLIIKVPMGTIIREEESNKVIVDLSKKGQEFVLVRGGRGGKGNTKFATATRQAPHYAEPGMPGEELSIVLELKLLADVGLLGFPNVGKSTLLSMTTKATPKIANYHFTTLKPNLGVVAIDGIEPFVMADIPGIIEGAAEGVGLGIQFLKHIERTRLLVHIVDISGIEGREPFEDFVKINEELKKYSVKLWDRPQIVVANKSDLLYDDEVFEEFERKVKELGFAKVYKMSAATRDGVDEVIKEAARMLKEIPVKELEISEDEMYIPEEKRFTYVIDIEKDDEYNTYVISGTFVDRLLSAVNIHDADSLRYFHKVLKNKGIMNELREMGIEDGDVVRLNDFEFEYLL
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MELT_CAEBR
Sequence: MHYLLSRLLHQRQLNASAQLFNVSHYDVITDMSNTFTCLKEIINDPTYPFNKVDQSVVEIVIARLTAAIRETGSIESYAAELVDVLDEVLKHPMTTLNEKSRDVDSPHCKIASDLLSSLFLHYGKKSVMTLTIPVALKCLNSENAELVKNTTSYISLAAIHNGKSLSSHALQIITKVVKGNYSLIRVLPHIYQDNKEPFHAQLSQLIDLLQNQEVDCSEKLSLLQLASMVANTKPEVLIPYLPRFDVYLLSPQLSTALLNIYMSLISQNRTKALSQFLPTLKLAAQSNEFVNNRTTICKIIANIGRVSSTLASEAVDELVLMARHNLAEPQLLQSVLNEIEAIGSMYPTSLRRHVAFFQTLPSSRTIERILGHLNLNNENIPLEVKKQSTESLLSKNSKVFGNLITSGGRTVFEVCESPTVELCELDRNTHSLAMQYQNNRSSGSLSRRSHASIAHSLGAGTHGPYSDINESRELSMISMPSSSRTNVHLSQAASSSRGHSLPQTFSPQAMTQIQMGKDGRVRPVAGGRRPVQWPAGSTETTFPAHLGPVTTSKMCALNEEDEKWINSDRNDVVYKFVEHRKNKIRRYIGEVNTRFPIPVQCTVEGSKSSKHRMVIHFSCQTRSSPCCVFTKEYLFAFKTKYPAFWLHFMFLQMECSAITQFGEVAGKDSQQYQTLEHCWKCLPSSTTKNVLFDTMITAAFPNSKDQDKLIKELDEAGFFAYFTMDSSNNMWNCISCTNPEKVKYFVEEGGVEKVLEGQLKEKKGRWRFLKRWNTKYFTLSSAALNYSTQHMPTDSRALLPSIDLRSIRSVRSLGRGKKARKSLRKAFEIFTADNTSMILKAKDEKNAEEWLHCLQIAMAHARRELS
What are the official names of this protein?
Protein melted homolog.
What is the protein family that this protein belongs to?
Belongs to the MELT/VEPH family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AGAR_ECOLI
Sequence: MSNTDASGEKRVTGTSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDSTTPSVEPSVEDKSALNTAMKRSVAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQSLQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSLEGLRKAGVEVILVGE
What is the function of this protein?
Probable repressor for the aga operon for N-acetyl galactosamine transport and metabolism.
What are the official names of this protein?
Putative aga operon transcriptional repressor.
Protein: KCJ12_MOUSE
Sequence: MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEVATDRDGRSPQPEHDFDRLQASSAALERPYRRESEI
What is the function of this protein?
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells.  Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues.  Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.
What are the official names of this protein?
ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir2.2, IRK-2, Potassium channel, inwardly rectifying subfamily J member 12.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: C80B3_PAPSO
Sequence: SLVAVVITTFLYLIFRDSSPKGLPPGPKPWPIVGNLLQLGEKPHSQFAQLAETYGDLFSLKLGSETVVVASTPLAASEILKTHDRVLSGRYVFQSFRVKEHVENSIVWSECNETWKKLRKVCRTELFTQKMIESQAEVRESKAMEMVEYLKKNVGNEVKIAEVVFGTLVNIFGNLIFSQNIFKLGDESSGSVEMKEHLWRMLELGNSTNPADYFPFLGKFDLFGQSKDVADCLQGIYSVWGAMLKERKIAKQHNNSKKNDFVEILLDSGLDDQQINALLMEIFGAGTETSASTIEWALSELTKNPQVTANMRLELLSVVGKRPVKESDIPNMPYLQAFVKETLRLHPATPLLLPRRALETCKVLNYTIPKECQIMVNAWGIGRDPKRWTDPLKFSPERFLNSSIDFKGNDFELIPFGAGRRICPGVPLATQFISLIVSSLVQNFDWGFPKGMDPSQLIMEEKFGLTLQKEPPLYIVPKTRD
What is the function of this protein?
Involved in the biosynthesis of benzylisoquinoline alkaloids.  Catalyzes the 3'-hydroxylation of (S)-N-methylcoclaurine.
What are the official names of this protein?
(S)-N-methylcoclaurine 3'-hydroxylase isozyme 1, Cytochrome P450 80B1, Cytochrome P450 80B3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Note=Like CYP80B3b (AC I3V6B1), the full-length CYP80B3 is probably anchored to the membrane by a signal anchor.
Protein: LYSY_CALMQ
Sequence: MRRACIIGASGVIGGELLRLLLGHNNVEVVCATSRRFAGEFIYRVHPNLRGFINLKFTQPSIDAVLKSESDVVFLALPHGESVKWVPKLVESGLLAIDLSADFRLKNPDDYVKWYHWPQPHPYPDLLKAAAYGLPELHRDEIKATKVIAVPGCMATASIVSLAPLVKGHLINNDFIVVDAKIASSGAGAEGTVLDYHWHRTHVVRPYQPVGHRHTAEIEQELSLLAGSQVNVAFTPHAVDMVRGIFVTGHARLSGSISEPDLWRAYRGMYGNERFIRIVKDKAGLAHYPSVKYVVGTNMVDVGFELDQRLNRVVVFSAIDNLIRGAAGQAIQSFNINQGFPEDEGLRFITPYPV
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.
What are the official names of this protein?
Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2C23_ORYSJ
Sequence: MEKRMETLEQIKETLRETSKLVPDIVRAAVGLEHHYQTVELPHDDGCVKSFAAAFLRPQAQEQAHGDGEVQQAVRMESASCYVPDHDEDAHFVHDAAGVVGGYRRRVGVDAGAFSRGLMTSAFAQLVTAEPGTPVCPYTLLERAYEETLESGAQGGSTAVILSLADGNVLRWAYIGDSAFAVLRDGRVVVRSVQQQRYFNAPYYLGGRRGDEGMTVGMVGEMKVRRGDVVVAGTDGLFDNMSDAELEKVVQIGTALGFSPKNMADIIGGTAYEMSRCLLKDSPFAVEWRKQHENEEGHFYGGKVDDITVVVACIVSSDS
What are the official names of this protein?
Putative protein phosphatase 2C 23, OsPP2C23.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: RM32_RECAM
Sequence: MAVPKRKPSVSRRKIRNVFIRAEMKKNLSNYSICKHCNYVKKKHHICNNCGYYKESLIYKIV
What are the official names of this protein?
60S ribosomal protein L32, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MP2K2_HUMAN
Sequence: MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
What is the function of this protein?
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases.  Activates the ERK1 and ERK2 MAP kinases (By similarity).  Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.