PharMolix/UniProtQA huggingface dataset:
Protein: ISPD_BORPA
Sequence: MSESLIAIVPAAGIGARASLPGEAAVPKQYRPLAGQPMLRHAVRALLADPRIVQVRVAVSAGDGWVEQALAGLPRTVWRPCGGPNRVDTVAAALADSGADADDWILVHDAARPGLPAAALARLIDACLDDAVGGLLALPVADTVKAGRQRVSRTVDRDGLWLAQTPQMFRAGLLRDALARARAAGLAVTDEASAVEAAGHAPRLVAGALRNFKVTWPDDFELMEKWL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: DUT_RUEPO
Sequence: MVAIRVIRDAGADTQVPLPSYETTGAAGADIRANLPDRGSLTLAPGGRALIPTGLRVEIPAGYEIQIRPRSGLALKHGITLPNTPGTIDSDYRGPLGVILLNAGAEPFEVVHGERIAQLVVAPVVQARFELTEALGETERGAGGFGSTGRG
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: KAD_LEGPC
Sequence: MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDDIIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDKEETIRKRLQVYHSQTAPLVQYYKEWAESGSKEAPKFHTISGTGTVEQIFDNIVTILET
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGDC_NEOFI
Sequence: MLRSLLLLAPLVGAAVLGVRDNSQECPGYKATNIREGRNSLTADLTLAGTPCNTYGTDLKNLKLLVEYQTDKRLHVKIYDADEEVYQVPESVLPRVDGKGGSGKKSALKFDYQANPFSFKVKRGGEVLFDTSGSNLIFQSQYLNLRTWLPEDPNLYGLGEHTDSLRLETTNYTRTLWNRDAYAIPEKTNLYGTHPVYYDHRGQDGTHGVFLLNSNGMDIKIDKTEDGKQYLEYNTLGGVFDFYFFTGATPKDASIEYAKVVGLPAMQSYWTFGFHQCRYGYRDVFEVAEVVYNYTQAKIPLETMWTDIDYMDRRRVFTLDPERFPLEKLRELVTYLHNHNQRYIVMVDPAVSVSDNVGYNDGMEQGIFLQTQNGSLYKGAVWPGVTAYPDWFHPDIQKYWNDQFAKFFDRKTGVDIDGLWIDMNEAANFCPYPCSDPEGYSRDNDLPPAAPPVRPSNPRPLPGFPGDFQPSSSSKRSTKGSKVGLPNRDLINPPYMIRNEAGSLSNKTINTDIIHAGEGYAEYDTHNLYGTMMSSASRNAMQHRRPEVRPLVITRSTYAGAGAHVGHWLGDNISEWSKYRVSIAQMLAFASMFQVPMIGSDVCGFGGNTTEELCARWARLGAFYTFFRNHNEITGIPQEFYRWPTVAESARKAIDIRYRLLDYIYTAFHRQTQTGEPFLQPMFYLYPKDKNTFSNQLQFFYGDAILVSPVTDGSQTSVDAYFPDDIFYDWHTGAALRGRGANVTLGNIDVTEIPIHIRGGSIIPIRSESAMTTTELRKKGFELIIAPGLDGTASGSLYLDDGDSIEQRATLELEFTYRKGRLRVKGKFGFRTDVKINAVTLLGQSAPASKSGSVASFDSGRQAVTIKTSLDLTGPSEIDLN
What is the function of this protein?
Glucosidase involved in the degradation of cellulosic biomass.  Has both alpha- and beta-glucosidase activity (By similarity).
What are the official names of this protein?
Probable alpha/beta-glucosidase agdC.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 31 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CSRA_PSEA8
Sequence: MLILTRRVGETLMVGDDVTVTVLGVKGNQVRIGVNAPKEVAVHREEIYQRIQKEKDQEPNH
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_NOSS1
Sequence: MDTKTFKRTLQHSENYNRKGFGHQAEVATQLQSEYQSSLIQEIRDRNYTLQRGDVTIRLAQAFGFCWGVERAVAMAYETRKHFPTERIWITNEIIHNPSVNQRMQEMQVGFIPVEAGNKDFSVVGNNDVVILPAFGASVQEMQLLSEKGCKIVDTTCPWVSKVWNTVEKHKKGDHTSIIHGKYKHEETIATSSFAGKYLIVLNLKEAQYVADYILHGGNREEFLQKFAKACSAGFDPDRDLERVGIANQTTMLKGETEQIGKLFEHTMLQKYGPVELNQHFQSFNTICDATQERQDAMLELVQENLDLMIVIGGFNSSNTTQLQQISQERGLPSYHIDVVERIKSINSIEHRQLNGELVTTENWLPAGKIVVGVTSGASTPDKVVEDVIEKIFALKATAAVF
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: FABZ_ACIAD
Sequence: MPMDIQKIREYLPHRYPFLLVDRVVEVGENNIVGYKNVSINEEFFQGHFPDYPIMPGVLIVEALAQISGILGFIMNNETPKPGSLFLFAGAEKVRFKKQVVAGDQLVLKAELVMQKRGIYKYNCTATVDGKVATTAEIIVSHLRTEQA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_HISS2
Sequence: MYNLQEITEEARKAIEALQDKSIESLEAIRVEYFGKKGHFTQLMQGLRDVSAEERPAVGAKINEAKQKVQAILNAKKVEWEEIALNERLAQERIDVSLPGRKMELGGLHPVSITINRVVQFFSKLGFTVEIGPEIETDYYNFDALNIPKHHPARADHDTFWFDAERLLRTQTSGVQIRTMEKMCPPIRIMAPGKVYRNDYDQTHTPMFHQIELLYVDKKANFTELKGLLHDFLRAFFEEDLQVRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPNEYSGFAVGMGVERLTMLRYNVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_HALOH
Sequence: MSKIRVYKLAKELGKSSKELVNILNDLGVEVSSHMSTVEDETAELVKGMLQEEDKPEEKISKKEPDKKDRKKTKGKKQMTRTATQKEGTEHGQKDTDRREMRVTVNPPLSVKELAEKADIPVNRIIKTLIGLGVMATVNHQIDEEIVKKLIDKMNLKIKISQGEDKEEKPDKVQTDIKDKPEDLELRPPIVTVMGHVDHGKTTLLDVIRETRVAESEAGGITQHIGAYQAVVQNKKITFIDTPGHEAFTAMRARGARLTDIAILVVAADDGVMPQTVEAINHAKAADIPIIVAINKVDKSNAQPDMVKQQLTEHGLVPEDWGGDTICVPISALKKKNIDELLEMVLLVAEMEELKANPDRPAEGVIVESQLDKGRGPVATVLVKNGTLKVGDPILAGYTHGKVRAMINDQGKRIKEALPSTPVEVLGFSDVPAAGDYVQVLEDEKEARAIAEERLQKKQERDLQHDGRISLDGLYQQIKEGGVKELNLIIKGDVHGSIEALRESLVKLSTDEVTVNIIHTGVGAINETDVNLASASNAIIIGFNVRPDSNARKLAEREKVEIKTYRVIYKIIEDLKDAMAGMLEPELKEEVTGRAEVRATFKVPNVGTVAGLYVKEGFINRNNKVRLLRDGVVVYEGDIASLKRFKNDVREVKEGYECGLGIEGYNDIKEGDQIETYTYREIKRTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCP1_SCHPO
Sequence: MEDENILRNAVNLQVLKFHYPEIESIIDIASHVAVYQFDVGSQKWLKTSIEGTFFLVKDQRARVGYVILNRNSPENLYLFINHPSNVHLVDRYLIHRTENQHVVGLWMFDPNDMSRIFNIVKESLLR
What is the function of this protein?
Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay.  Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP.  Decapping is the major pathway of mRNA degradation in yeast.  It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.
What are the official names of this protein?
mRNA-decapping enzyme subunit 1.
What is the protein family that this protein belongs to?
Belongs to the DCP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS3_CLOP1
Sequence: MGQKVHPHGLRVGVIKDWDAKWYADKKNFADNLIEDQQIRKFIKKELFSAGIAKIEIERSAKRVKLNIHTAKPGVIIGKGGSGIERLKASLKNIIAEKNVLINIVEVKNAETNAQLMAENIAAQLEKRISFRRAMKQTIQRAMKAGTLGVKTACSGRLGGAEIARTEQYNEGTIPLQTIRADIDYGFAEADTTYGKIGVKVWVYNGEVLPTKKVEKKEEANA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: YTMA_BACSU
Sequence: MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDGFLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAFRLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQDLRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEKLKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR
What are the official names of this protein?
Uncharacterized peptidase YtmA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
Protein: AT2A2_MOUSE
Sequence: MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYAPIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLKREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFDGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEQPGKECVQPATKSSCSLSACTDGISWPFVLLIMPLVVWVYSTDTNFSDMFWS
What is the function of this protein?
Involved in the regulation of the contraction/relaxation cycle (PubMed:23395171).  Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171).  Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation (PubMed:23395171).
What are the official names of this protein?
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA2, SR Ca(2+)-ATPase 2, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: M4A6C_MOUSE
Sequence: MIPQVVTNETITTISPNGINFPQKDESQPTQQRQDSLKKHLKAEIKVIVAIQIMCAVTVLALGIILASVPPVPYFNSVFSVLLKSGYPFIGALFFIASGILSIITERKSTKPLVDASLTLNILSVSFAFVGIIIISVSLAGLHPASEQCKQSKELSLIEHDYYQPFYNSDRSECAVTKSILTGALSVMLIISVLELGLALLSAMLWLREGVLTSLRM
What is the function of this protein?
May be involved in signal transduction as a component of a multimeric receptor complex.
What are the official names of this protein?
Membrane-spanning 4-domains subfamily A member 6C.
What is the protein family that this protein belongs to?
Belongs to the MS4A family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CDK1A_XENLA
Sequence: MDEYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNSFPKWKGGSLSANVKNIDKDGLDLLAKMLIYDPAKRISARKALLHPYFDDLDKSSLPDNQIRN
What is the function of this protein?
Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins.  Required in higher cells for entry into S-phase and mitosis.  May play a role in regulating the amplitude of the cyclic expression of circadian clock genes.
What are the official names of this protein?
Cyclin-dependent kinase 1-A, CDK1-A, Cell division control protein 2 homolog 1, Cell division control protein 2-A, Cell division protein kinase 1-A, p34 protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MOC2B_NEUCR
Sequence: MATQQPTQTDNSAQAQPPQTNPAKPTEISEPGIYVALTHDHLNYQSVIDRVRSPEAGAIVVFAGTTRNNFNSLPVQHLSYTSYAPLALRTMLTICRSILTKHGLKGIAMVHRLGVVPIGEESILIAVSSPHRQAAWRAGEEALEECKAKVEVWKREEFGGEGGGVWRANRDGAVGVKVDEPRIGKGEVDEKEDEGDSGNGGNDRKS
What is the function of this protein?
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin.  Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
What are the official names of this protein?
Molybdopterin synthase catalytic subunit, Common component for nitrate reductase and xanthine dehydrogenase protein H, Molybdenum cofactor synthesis protein 2 large subunit, Molybdenum cofactor synthesis protein 2B, MOCS2B, Nitrate nonutilizer protein 8.
What is the protein family that this protein belongs to?
Belongs to the MoaE family. MOCS2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_CALS8
Sequence: MNKLRKLKRDTDHRQALMRNLATSLFKHGRIMTTEAKAKDLRRVAEKLITIAKKGDLASYRRVLGYLYEEDVAYDLFQKIAPRYQGRNGGYTRIIKVGPRKGDGAMMVYIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: VH21_MYXVU
Sequence: MGVQHKLDIFLVSEGIAIKEANLLKGDSYGCTIKIKLDKEKTFKFVIVLEPEWIDEIKPIYMKVNDESVELELDYKDAIKRIYSAEVVLCSDSVINLFSDVDVSYTCEYPTIKVNTIKKYYSVQNRGMTYVHIESPINTKDKCWFVEKNGWYEDRTHS
What is the function of this protein?
Plays a role for multiplication of the virus in different cell types.
What are the official names of this protein?
Probable host range protein 2-1.
What is the protein family that this protein belongs to?
Belongs to the poxviridae C7 protein family.
Protein: UBIA_FRATW
Sequence: MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGCIINDIADVDFDKHVARTNTRPLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFVALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQIPVEAWIFYIATICWTIAYDTIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVVICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYIIKEFL
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NANT_CROS8
Sequence: MTKTTQLIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEIQDEFGLTTIQAASLISAAFISRWFGGLMLGAMGDRYGRRLAMISSIVLFSVGTLACGLAPGYTTLFIARLVIGIGMAGEYGASATYVIESWPKALRNKASGFLISGFSVGAVVAAFVYSLVVPVWGWRALFFIGILPIVFALWLRKNIPEAHDWEARRSEKTPVRTMVDILYRGEHRVINIVLTLLASVSLWLCFTGELNSAVIVAALGLVCAAIFISFMVQSSGPRWPTGVTLMVIVLFAFLYSWPIQALLPTYLKTELAYEPATVARVLFFSGFGAAVGCCVGGFLGDWLGTRRAYVYSLLASQVLIIPVFAIGGANVWVLGLLLFFQQMLGQGISGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPVLGALIAERLHLGAALCSLSFGLTFVVVLLIGLDMPSRVQRWLRPEALRTHDATDGKPLSGAQAVSGRKRGLVKSKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNPH_VIBPA
Sequence: MRPNDRKADQVRPIKITRNYTAYAEGSVLVEFGNTKVLCNATVEESVPRWLKGQGRGWVTAEYGMLPRATHSRTRREAANGKQGGRTMEIQRLIARSLRAVVDLQAMGEFMITVDCDVIQADGGTRTASISGASVAMADAFQHLVDSGKLKANPMKGHVAAVSVGLLGDEVLCDLEYVEDSAADTDMNVVMTEEGKMIEIQGTAEGEPFSHEQLMALLESAKVGITEIVAAQKAALAN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: OTC_SHIDS
Sequence: MSGFYHKHFLKLLDFTPAELNSLLQLAAKLKADKKSGKEEAKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLVYAGDARNNMGNSMLEAAALTGLGLRLVAPQACWPEAALVTECRALAQQNGGNITLTEDVAQGVEGADFIYTDVWVSMGEAKEKWAERIALLRDYQVNNKMMQLTGNPEVKFLHCLPAFHDDQTTLGKKMAEEFGLHGGMEVTDEVFESAASIVFDQAENRMHTIKAVMVATLSK
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERD23_DANRE
Sequence: MNIFRLSGDVCHLIAIIILFLKIWRSKSCAGISGKSQVLFALVFTTRYLDLFTSYISAYNTVMKVVYLLLAYSTVGLIFFRFRNSYDSESDSFRVEFLLVPVAGLSFLENYAFTPLEILWTFSIYLESVAILPQLFMITKTGEAESITAHYLLFLGLYRALYLANWLWRFHTEGFYDQIAVVSGVVQTIFYCDFFYLYFTRVLRGSGKMSLPMPV
What is the function of this protein?
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
What are the official names of this protein?
ER lumen protein-retaining receptor 3, KDEL endoplasmic reticulum protein retention receptor 3, KDEL receptor 3.
What is the protein family that this protein belongs to?
Belongs to the ERD2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.
Protein: M1_I02A5
Sequence: MSLLTEVETYVLSIIPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYKKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTTEAAFGLVCATCEQIADSQHRSHRQMTTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVANQARQMVQAMRTIGTHPNSSAGLRDNLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: NLRC4_HUMAN
Sequence: MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILKKGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDVLLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFRTLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA
What is the function of this protein?
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016).  The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).
What are the official names of this protein?
NLR family CARD domain-containing protein 4, CARD, LRR, and NACHT-containing protein, CED-4-like protein Clan, Caspase recruitment domain-containing protein 12, Ice protease-activating factor, Ipaf.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Inflammasome.