PharMolix/UniProtQA huggingface dataset:
Protein: MINE_ACICJ
Sequence: MNLFNFFTRSRSTAPVARERLQLLLAHERALSGQSDLAVVLQEEILAVIAKHVSIDREKVNVKLGRDGTVSTLEIDIEMPEAALVKN
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: DDX50_MOUSE
Sequence: MPGKLLWGDIMELEAPLEESESQRKERQKSDRRKSRHHSESEERTETRENGVTDDLDAPKPKKAKMREKLNGDTKEGLRFSDEFSPSHKSRRKDLPNGDVDEYEKRSKRVSSSENSHKSSDKAEETLTREQKEGAFSNFSISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSVACFYGGTSYQSQINQIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDIIHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICVCFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSHVTRMCLLKGNMGVCFDVPTSESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNPRQRSGWSGGRSGRSGRSGGRSGGRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGGHKRNFD
What are the official names of this protein?
ATP-dependent RNA helicase DDX50, DEAD box protein 50, Gu-beta, Nucleolar protein Gu2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DNAK_ACTSZ
Sequence: MGKIIGIDLGTTNSCVAVMDGDKPRVIENAEGDRTTPSIIAYTNDNETLVGQPAKRQAVTNPKNTLFAIKRLIGRRFEDNEVQRDVDIMPFKIIRADNGDAWVDVKGDKLAPPQVSAEVLKKMKKTAEDFLGETVTEAVITVPAYFNDAQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKGKGNQTIAVYDLGGGTFDLSIIEIDEVGGEKTFEVLATNGDTHLGGEDFDNRVINYLVDEFKKEQGVDLRNDPLAMQRLKEAGEKAKIELSSAQQTDVNLPYITADATGPKHLNIKLTRAKLEALVEDLVARSMEPVKVALKDAGLSVSEIDDVILVGGQTRMPLVQQKVAEFFGKEPRKDVNPDEAVAVGAAVQGGVLSGNVTDVLLLDVTPLSLGIETMGGVMTTLIEKNTTIPTKKSQVFSTAEDNQSAVTIHVLQGERKQASANKSLGQFNLEGINPAPRGMPQIEVTFDIDADGIIHVSAKDKGTGKEQQITIKASSGLSDEEIQQMVRDAEANADADRKFEELVQARNQADALVHATRKQLTEAGDKLSADDKAPIEKAVSELEDAVKGDDKDAIEAKSQALIQVSEKLMQAAQQQAQANTQGQQSQGGNDDGVVDAEFEEVKDNK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: GPMA_PECAS
Sequence: MAVTKLVLVRHGESQWNNENRFTGWYDVDLSEKGRSEAKAAGQLLKDEGFAFDFAYTSVLKRAIHTLWSVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAITPPELTRDDERFPGHDPRYASLSDKELPQTESLALTIERVVPYWTETILPRIKSGERVIVAAHGNSLRALVKYLDNMGEDEILELNIPTGVPLVYEFDENFKPIKRYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: CYB_MARLE
Sequence: MTNLRKTHPIIKIINHSFIDLPTPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFIHVGRGIYYGSYLFKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGNTLVEWIWGGFSVDKATLTRFFAFHFILPFIIMALAMVHLLFLHETGSNNPTGLNPNSDKIPFHPYYTIKDALGFMLMILVLMTLAMFSPDLLGDPDNFTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILVLIIIPLLHMSKQRSLMFRPISQFLFWLLTANLLTLTWIGGQPVEQPFIIIGQLASILYFTLIIVLMPLAGMLEDNMLEPKFP
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PLSB_XYLF2
Sequence: MPKKNSPLLPKETTTTQSSVDTSGSSNLTWPVSEHTIRRPLWARLLGQILDPWLDLSIEPEHSVQYNDGRPIIYVLEDYGLCNTLILDKACRKTKLPSPLIPLSGNPLQRKRAYLALSRRSSSNSLIPNQRGGKTHSDSLANLLQAHRIRDTLDVHLVPVSIFIGRTPDRQSGWFAVLFSENWALVGRFRRILAILLNGRNTIVCFAPPISVRQTLNEGLPPERTLRKLQRVLRTHFRRIRETVIGPDLSTRRLLVDNVLATEAVREAIGAQAKRDGTDLSETWRKAQAYAWEIAADYSSPVIRSADFLFSHVWNRIYAGVLVHHVDSFKEISPGHEIVYVPSHRSHMDYLLLSYCLYKCSIGLPHIVAGINLNLPVVGTLLRKCGAFFIRRSIKGNMLYSVVLSEYVAQLVAGGYSLEYFIEGGRSRTGRLLQPKGGMIMMTVQAFLRQPRRPVLFQPIYIGYEKLMEGTSYLDELSGEPKKKESIWRVFWNIPKVLKQKYGQVVVNFGEPIALNDVLAELAPEWEGQALNENEKPAWLSSTVNHLARQIQTRINSAADVNPINLLALALLSTPKHAMGEADLIAQITLCKKILLELPYSNRVTITPHTPERIIAHAEQINILTRVHHPLGDVLRVDGDNAVLLSYFRNNVLHLFTASAWVACCFKNNRRMSRIALIRLGVGMYPFLQAELFLPWTEDQFAQHIQQVIELFVREGLLLSAGNEEEDPLTRNTSQTDEVFRLRAISHSLQQAFERYYITISILVKNGPGTLSASELESLCQLAAQRLSLLYASTAPEFFDKGLFRGFIQKLRELNLVWPDTYSKLLFDERLDTSAKDAQVILGRELRHTIERISPEATKPAPK
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRB_HAHCH
Sequence: MPRIDDELSPLQLNRFQQLRHFLTIEGLSRKHLTDILDTADTFIEVGSRSIKKVPLLRGKTVANLFFEASTRTRTTFELAAKRLSADVLNINITTSATSKGESLSDMLRNLEAMAVDMFVVRHAQSGAPHFIAKSVTPRVSVINAGDGRHAHPTQAMLDMLTIRQHKHKFEGLKVAIVGDILHSRVARSQIQALNLLGAEEVRVIAPDTLLPPYIDQFGVKVFSSMKEGMRDVDVVIMLRLQKERMEGALLPSEQEFFRLYGLSQDKLALAKPDAIVMHPGPINRGVEIESAVADGPQSVILNQVTNGIAVRMAVMSMAMSGQIAELTADEEVA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: DHQS_METBF
Sequence: MKKKSVWIKADEGGWEQQKERITTGLESGADCVLVNPGDVGKVRELGNIPVATFGRDNKSGAEIIVVGKRGEGDGTKPLPLETQGSLDINAATLLRDKEVAVGGYVIIKDKRYEQFAAEMGKVCDFLIVTGTDWKVIPLENLIAELQRYDVKIIFGVKNAEEARLAFKTLETGADGVLLNSGNIQEIKDTIQAAREMENERTELESAVITRVEPLGMGDRVCVDTCNLMQKGEGMLIGSQASGMFLVNSESDDSPYVAARPFRVNAGAVHSYIKIGDKTRYLSELRTGDAVTIIDSKGRQREGFVGRVKIESRPLMLIEAKAGNRTLSAILQNAETIKLVGKDGNPISVAKLKKGDEVLVRLEEGARHFGKKIEETIIEK
What is the function of this protein?
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
What are the official names of this protein?
3-dehydroquinate synthase, DHQ synthase, 3-dehydroquinate synthase II.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type DHQ synthase family.
Protein: RECX_THESQ
Sequence: MDYYQWRKKNRGKKRNLQAKKPLNYALRLLKYRVRFEDELRERLKKQGFADEEVESTITTLKKQGYLDDEKAAYLFALDEMRLKLFGPRVVKMKLKSLGVDEEIIERAIEKALEEIDFHEELKRLKGRFKDRWELRDYLYRRGFDSSLIEEILNKIDGGEE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2953_YERP3
Sequence: MKTKLNELLEFPCSFTYKVMGIAEPQLVDQVVEVVQRHAPGEYTPQVKPSSKGNYHSVSITITATHIDQVETLYEELGNLELVKMVL
What are the official names of this protein?
UPF0250 protein YpsIP31758_2953.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: AGRB2_PONAB
Sequence: MTPACPLLLSVILSLRLAAAFDPAPSACSALASGVLYGAFSLQDLFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCAHFAPRLLPLDHYLVNFTCLRPSPEEAVTQAESEVGRPEEEEAEAAAGLELCSGAGPFTFLHFDKNFVQLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPGEAGAGSATTTSPGPPAAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKKAAAGEIIYNKCPPNASGSASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYSGDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDAENKEKWDDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPVSAVSSDITFPMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATSGAAGSPGRGRGPGTVPPGPGHSHQRLLPADPDESSYFVIGAVLYRTLGLILPPPRPPLAVASRVMTVTVRPPTQPPAEPLITVELSYIINGTTDPHCASWDYSRADASSGDWDTENCQTLETQAAHTRCQCQHLSTFAVLAQPPKDLTLELAGSPSVPLVIGCAVSCMALLTLLAIYAAFWRFVKSERSIILLNFCLSILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGISDKSKKQRAGASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQDVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGSLSFSPLPGNILVPMAASPGLGEPPPPQEANPVYMCGEGGLRQLDLTWLRPTEPGSEGDYMVLPRRTLSLQPGGGGGGGEDAPRARPEGTPRRAAKTVAHTEGYPSFLSVDHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKMGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSTAKREKRWSVSSGGAAERSVCADKPSPGERPSLSQHRRHQSWSTFKSMTLGSLPPKPRERLTLHRAAAWEPTEPPDGDFQTEV
What is the function of this protein?
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions.  Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ.  Involved in angiogenesis inhibition (By similarity).
What are the official names of this protein?
Adhesion G protein-coupled receptor B2, Brain-specific angiogenesis inhibitor 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSRC1_RAT
Sequence: MGRRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRRPRSESRSWSRDRQPRSHSYERRRRRRSSSSSSYGSRRKRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRPRSHSRSSERSSHRRTRSRSRDRDRRKVRDKEKREKEKDKGKDKEAHTIKRGDCGNIKAGLEHLPPAEQAKARLQLVLEAAAKADEALKAKERNEEEAKRRKEEDQATLGEQVKRVKEIEAIESDSFVQQTFRSSKDVKKSVEPSEVKHVTPASGPASVAADPPSTGKEIDPDSIPTAIKYQDDNSLAHPNLFIEKAEAEEKWFKRLIALRQERLMGSPVA
What is the function of this protein?
Plays a role in pre-mRNA splicing.  Involved in both constitutive and alternative pre-mRNA splicing.  May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity).
What are the official names of this protein?
Serine/Arginine-related protein 53, SRrp53, Arginine/serine-rich coiled-coil protein 1.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm.
Protein: Y887_METTH
Sequence: MVSMEESSVFDYIRENRRTIVLSFLAVAVVIFLIGFFAGFGDILRALEGTSPYFLALNFVLEAIILILWTLRWRLILNVVDDAPSFPRLMMLLFTSIFGNNITPGAAGGEPLRAYLLREVEGTPFEIGFASSTADRVFEFIPFALISILSAVLIMTWEISIWTRIVVSVLILVTIAGFSLAVYAGMNKKIAQRIALSVTRRLVSWFSRFREGGISFAGIHEKVIFYINRFNDGFSTAITDRRVFVIGFFISLGMWALDVCRLYVCFLAVGVSPPAVPLIIIYTVGILISLLPILPGSLGLREGILVGLFAVAGIGADYVMAASVVDRIASYIAPTLIGLIAAIYYGKQMTS
What are the official names of this protein?
UPF0104 membrane protein MTH_887.
What is the protein family that this protein belongs to?
Belongs to the UPF0104 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NS1A_TASV1
Sequence: MAAAAASALGASAPKALAPADGPIVAGLDKLVNLEGVHDLFEAMRGAYGEDPAWKGLMSCDVVYLKDITTAIGVKDTSVGIFRKFSDGCSWCPTGAECFLSMKDLAYMKAQSAKAQRLTASLATTSNLIARAMRAESELKRARDEERKVDARYKDILEHSLAARKALQKELDETRERELHLLKELGKRSSIRTKAFSFFDWLFMAVVFFLFLHYTSAECVKPDFGCLVVNSNLPVPSLTFHDVMARCYNTFGNIVLSSQIDAARLREECEQSANKFLGTHIGDPAHKVWCENRLETLIPVECDSSEFLEIFTSNLNAFMVSVSQFYKTISYYKLDALVTFAFSAALATNKLKMVMVLPLLLVALYLNVPPITVTIASVIFQPLILPFVGFQLVFPNFLPYNLFVAWVWMVCQAFFSSDGVKLLVSVSTALVQVVFLAVWSISVIVLQQLSIPMVAQILLFVATLTVSVGVKFANSTITVVHPDGNTEKVSRVTLVRQSMAKRISQIKQSLTIRGVIPSGPNRFDSIVVVEGQGGSGVGWRFMNSIFTAGHVVQGSKFVTIKSESTQVKVKVKRVIDLFECVDTLVEIPLTKEFQHIKPLRLAKKVEDSYLQLCAFKPDMVEKASYQGWCTIDSGFIFNSFNTQFGNSGAPYVDSDGRLVGMHLGSQGVISQGVVLVDTLKTQFLAQQSQIDDQLMERIIEGTKVSHAAILTELDRMRTKVEEVALVSARVNQLESQLKDLYEFSSNSIKCLSDDIEKMVCAQLFDEINLQSVMEKISALPPTEKLAKLVEVFVEQKKKGKTKRTARGGKHALGKKYLSKAHFSRMRMLTEEEYNKMVEDGFSPDEIKEVVDQLREQAWQNYLIDNDIGEDDDLDWYDDMLEDERLNEEIDRRVEAALEDRGELAYQKIRRTFVDQALIHLITLKKGNWQTTKVECQPEREEAYKEQFQKAVKQEDLTEGTSYAIYSAGDATILIENKEIDHTEIKPVTTGAKTVQEYPKDARTTVATFDDNKKDIVKTKRTTEIVLEQRKKTCRTCGETRPHNHKMCRDRHTRRFCFWCGVVHSDVEGHSRDLKCPKCSAGFANLREMEQHAVTTCSKN
What is the function of this protein?
Protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.
What are the official names of this protein?
Non-structural polyprotein 1A.
What is the protein family that this protein belongs to?
Belongs to the astroviridae polyprotein 1A family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: BRNP3_MOUSE
Sequence: MIWRRRAGAELSSLMALWEWIVLSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQGFSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRSEGSETSTNSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKDNDCWCHCGPKFPECNCPSMDIQAMEENLLRITETWKAYNSDFEDSDEFKFFMKRLPMNYFLNTSTIMHLWTMDSNFQRRYEQLENSMKQLFLKAHRIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFSEETHSCTCPNDQVVCTAFLPCTVGDASACLTCAPDNRTRCGTCNTGYMLSQGLCKPEVAESTDHYIGFETDLQDLEMKYLLQKTDRRIEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYVNPFGGSHSESWFMPVSESSFPDWERTKLDLPLQCYNWTLTLGNKWKTFFETVHIYLRSRIKANGPNSNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTVDYDTTKLCS
What is the function of this protein?
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.  Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed.  May play a role in cell pituitary tumor development.
What are the official names of this protein?
BMP/retinoic acid-inducible neural-specific protein 3.
What is the protein family that this protein belongs to?
Belongs to the BRINP family.
What are the subcellular locations of this protein?
Secreted. Mitochondrion.
Protein: IMP16_NAUMA
Sequence: PGGGVSGALSSLVQSLVR
What are the official names of this protein?
Uncharacterized protein IMPP16.
Protein: IFGH_PENRF
Sequence: MSTSFDHSVILSPLDHIAPQAYVSYLLSFQTANSTHCLSLLEAGITRLTKVLPLLLGHIVVNPELDGKYNIQSVQIPCTKEDRTILVHKHHPFPMESALGGVQSGMSMLETSDSKQHLCPLPPLIPSTERQPVIRFQANIFTDAIVLAMTFSHIVFDGTGAAKILALLGRCCRDPSVTPLPLIIDEQDRAQSAIFAGLADTSPAQDHTAELGPAPAIHPVPLDAASLRTCRFEFNSERILQLKYQCSQVLKNACMFQPNSASIPVADLPPFLSSNDVLTSALADAIQRVKSQSKTYDCLDLCMAVNMRGRIELSAAREFLGNMACNLRLKTPGPEYTGPEQCLSCRKTHDCPIQTDQLRFLTDLACKVRNKVRNMDRKYFQSCMTYIANQKDWSQTGMIFTDLAFSSWRHLDIYGLDFGDSFGIVHNFDLSFGLIEGDVIFLPKRLTCDQKEAGWDVHITLPAKDLEALVKDDLIRWLMGRDGE
What is the function of this protein?
Fumigaclavine B O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids (PubMed:28620689).  The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:28620689).  The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan (PubMed:28620689).  The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:28902217).  The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:28620689, PubMed:28902217).  The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:28620689).  Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A (PubMed:28620689).  Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 (PubMed:28620689, PubMed:28902217).  The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions (PubMed:28902217).
What are the official names of this protein?
Fumigaclavine B O-acetyltransferase ifgI, Isofumigaclavine biosynthesis cluster B protein I.
What is the protein family that this protein belongs to?
Belongs to the fumigaclavine B O-acetyltransferase family.
Protein: RGI2_YEAST
Sequence: MTKKDKKAKGPKMSTITTKSGESLKVFEDLHDFETYLKGETEDQEFDHVHCQLKYYPPFVLHDAHDDPEKIKETANSHSKKFVRHLHQHVEKHLLKDIKTAINKPELKFHDKKKQESFDRIVWNYGEETELNAKKFKVSVEVVCKHDGAMVDVDYKTEPLQPLI
What is the function of this protein?
Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
What are the official names of this protein?
Respiratory growth induced protein 2.
What is the protein family that this protein belongs to?
Belongs to the RGI1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM10_ASPFU
Sequence: MEDDDRPRKYPKLNHDEVQEGSEPVMTGAVGAVHDDDAESADSDNRASPSNDRIDNDVKQACDEEGQDAHGKDGPPTLSKNQLKKLKRKEHWEAMREQRKVKRKEKLVAKRERRRAALEQAKQEGAEATEETRKAFESTQKKFQRSTLLPVTLVLDCSYDDLMLDKERVSLGAQITRSYSDNSRAPFRSHLVVSSFNKLLKERFDTVLGKTHENWKGVRFLQEDFAEAAEMAKEWMQGPKGGQLAGVFADKADAKPEDGEIVYLSSDSPNILTELKPYSTYIIGGLVDKNRHKGICYKSAVAKGIKTAKLPIGEYIQMAHRQVLATNHVVEIMIRWLELGDWGKAFIQVIPQRKGGKLKSADHESEDQTPRESVEAVEAEPDGEGAAAEAGEGGKE
What is the function of this protein?
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.
What are the official names of this protein?
tRNA (guanine(9)-N1)-methyltransferase, tRNA methyltransferase 10, tRNA(m1G9)-methyltransferase, tRNA(m1G9)MTase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LNT_RICFE
Sequence: MYKPKIICLLLGMLSGLVFAPTFFIPALLTLSYLCYIVQKSENWQEAAKFGYLFGFGHFLSGIYWISIGVSVYIADFWWAIPFALFGLPIVLAFFISASCTLSFFAKNNKYYQFIFCICWVLFEWVRSWIFTGLPWNLIGYAFSFSDILIQTLSIIGIYGLSFIVIYISTSAYPLFRKQFTQLKILLASSVLILSVIVIYGAVRLSNNPTNFTDIKVRLVQPSIPQTEKWNEEEFWHNLMLHINLSENSEPTDLIIWSEAALIVPDDIPQVKSELLQMLNSTNAILITGGISDNKKQGDEFELYSAMYALDKNDHKLFEYHKSHLVPFGEYMPLKKILPFKKLTHGLIDYKEGDGGLVYLEKYNLKIKPLICYESIFPDFVRTNNEIVDVIINITNDAWYGKSSGPYQHFHISRSRAVENGLPMIRVANNGISAIVDPFGRTIEKLNLNEINYTQGLIPKKLNSPTIFSQFGNFTILLLIVFILLINYLLALILDN
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTNN_SALSV
Sequence: MKIGIIGAMEEEVTLLRDKIDNRQTITLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLASTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAESCIRELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPDAVAVEMEATAIAHVCYNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSTLMVETLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: RLA1_DAVTA
Sequence: MSAAELASSYAALILADEGLEITADKLQALISAAKVPEIEPIWTSLFAKALEGKDVKDLLLNVGSGGGAAPAAGGAAAGGAAAVLDAPAEEKAEEEKEESDDDMGFGLFD
What is the function of this protein?
Plays an important role in the elongation step of protein synthesis.
What are the official names of this protein?
60S acidic ribosomal protein P1, Allergen Cla h XII.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Protein: RL5_OLEA2
Sequence: MTRLQNIYREQVAPVLQKEFNYKSSMQLPKLEKISLNIGLGEASQNQKLLEEAVKELTAIAGQKAVITRAKKSIASFKLREGMPIGCRVTLRGDSMWDFLDKLMNFALPRVRDFRGIADRGFDGRGNFTLGIKEHTIFPELEVDRVDNPKGMNITIVTSAKTDKEGKFLLDKLGMPFKK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RPPH_BRADU
Sequence: MARYEDLPYRTCVGVMLINAKGLVFIGRRAGGIEHIDDTHVWQMPQGGVDPGEDTWAAAKRELYEETSVRSVERLGEVPDWLIYDIPRTVAGRAWKGRYRGQRQKWFAVRFTGKDSEINVENPGGGHKAEFVSWRWEPMKNLPGLIIPFKRPVYERVVKEFSALAEE
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: ACCD_AFIC5
Sequence: MNWLNNVVRPKIRSILKRETPENLWIKCPDSGQLVFYKDVEANQFVIPGSNYHMRMGATARLKSIFDNETWFDVALPDVAADPLKFRDERRYADRIKDARAKTGMNDAVKVGYGRIESTPAVVAVQDFDFMGGSLGMAAGEAIVTGLQLAVEKHAPFIMFAASGGARMQEGILSLMQMPRTTVAIQLLREAGLPYIVVLTNPTTGGVTASYAMLGDVQLAEPGALIGFAGARVIEQTIREKLPEGFQRAEYLKEHGMVDMVVHRHEMRPTLARLCRLLMKVPAPHADEVAAPPPPDVEGPPPAAEPVALPPA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.