PharMolix/UniProtQA huggingface dataset:
Protein: NDUS1_RECAM
Sequence: MVNVFVDGLSVEVKKGATILQACAQVGIEIPRFCYHERLSIAGNCRMCLVEVEKSPKPVASCAMPVMDNMKIFTNTPLVKKAREGVLEFLLVNHPLDCPICDQGGECDLQDLTMVYGSDRGRFHEYKRGVEDKNIGPLVKTVMTRCIHCTRCVRFATEVAGVPDLGTVGRGRDTEISTYIQKVFNSELSGNVIDLCPVGALTSKPYAFTARSWELQSTESIDVSDAIGSNIRIDVRGSEIMRILPRLNEDVNEEWISDKARFCYDGLKRQRLNNPIIKENGQYKTVTWEKAFNFILKNLQEIQNSNRIVGVVGNLMDVESILLFKELLNKLGSSKIYLESSTPILQLNDDEKEDQILNNADFRNNYISNTPLAKIEESDLCLLIGTNIRLEAPLLNTRIRKRYLQGNYSVYSVGPTNNLTYNTENLGNDISTLLEISEGRHPFCKKLMKSKKPLIIIGTHVLQRTDGTSIIELVKTLFKYTQIKTSNWNGFNILHTSASSVGALDLGIGSTKRYSEKISNSKIEKHFIYLLGADEIRIENSKEHFIVYQGHHGDYGANIADVILPGSAYTEKTATYVNVEGRVQNTKSAFYAPGNAREDWKIIRALSEVLNKKLPYDSFEDIHTRFMSIAPHLLKVNAIEKNKIVIENSLPFKGLIKNIGFKPLFNNFYLTNAICRSSQTMAKCSSIYKLN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).  This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme.  It may form part of the active site crevice where NADH is oxidized (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 75 kDa subunit, Complex I-75kD, CI-75kD, NADH dehydrogenase subunit 11.
What is the protein family that this protein belongs to?
Belongs to the complex I 75 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Note=Matrix and cytoplasmic side of the mitochondrial inner membrane.
Protein: SYM_SALDC
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSDENRELSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSADQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTTSFDEYWKKDSDAELYHFIGKDIVYFHSLFWPAMLEGSHFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLKHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLAAELADPQLYKTFTDAAAVIGEAWESREFGKAIREIMALADIANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPTLSERVEAFLNSELNWDAIEQPLLGHKVNTFKALYNRIDMKQVEALVESSKEEVKAAAAPVTGPLADFPIQETITFDDFAKIDLRVALIENAEFVDGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRQTVMVANLAPRKMRFGVSEGMVMAAGPGGKDIFLLSPDDGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_SHEB9
Sequence: MLAKRLVPCLDVKDGKVVKGVQFRNHEIVGDIVPLAARYAEEGADELVFYDITASAHERVVDKSWVSRVAEQIDIPFCVAGGIKTISQARELLAFGADKISINSPALTDPSLISRLQDEFGRQCIVIGIDSFFDATSNSYKVKQFTGDEAATKDTQWFTQDWVEEVQKRGCGEIVLNVMNQDGVRGGYDIKQLSLVRAICDVPLIASGGAGTMAHFRDVFIEAKVDAALAASVFHKAIINIGELKAYLAAEGIAIRR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_STRP4
Sequence: MATIKEIKELLVTVKELESPIFLELEKDNRSGVQKEISKRKRAIQAELDENLRLESMLSYEKELYKQGLTLIAGIDEVGRGPLAGPVVAAAVILPKNCKIKGLNDSKKIPKKKHLEIFQAVQDQALSIGIGIIDNQVIDQVNIYEATKLAMQEAISQLSPQPEHLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELMKEYDQQFPGYDFATNAGYGTAKHLEGLTKLGVTPIHRTSFEPVKSLVLGKKES
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_SHEON
Sequence: MSTPTPLSYKDAGVDIDAGNALVNNIKAAVKRTRRPEVMGNLGGFGALCELPTKYKQPVLVSGTDGVGTKLRLAIDYKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATAVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIQHLLEPTKIYVKSLLKLIEASDVHAMAHITGGGFWENIPRVLPENCKAVIQGDSWQWPAVFSWLMENGNIAEYEMYRTFNCGVGMIVALPADKVDAALALLAAEGEQAWLIGAIAAREGNEEQVEIL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADR_SERP5
Sequence: MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETVARLDHQSVPQLIDNLLSVRTNIAAIFIRAAVRNHPEAAQEVLAKATQVEDQADAFNLLDYEIFRGLAFASGNPIYGLIFNGLKGLYTRVGRYYFSNPESRKLALTFYSKLSTLCHEKSYDQVMDCVRNYGKDSGAIWQSMQGTMPSDLTEARR
What is the function of this protein?
Multifunctional regulator of fatty acid metabolism.
What are the official names of this protein?
Fatty acid metabolism regulator protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTB_ACIB5
Sequence: MKGYEVNFDGLVGPTHHYAGLSFGNEASTKNRNNLSNPKLAAKQGLLKMKALADMGMKQGVLAPHERPHVPMLRRLGFTGDDISVVAQAMRYSPELLSSLSSASPMWTANAATVSPSADSQDERVHFTAANLNNKFHRSIEAETTSQVLQAIFKNERHFVHHEALPQVALFGDEGAANHNRLGGDYAKRGVQVFVYGQQHLNNGLPGPKRYPARQTREASEAIARLHRLDEAHTVFVQQNPDVIDQGVFHNDVIAVSNQQVLFHHQHAFLNQDQAFAEIRQKMASIGEDFISIEVPENRVTVDDAVATYLFNSQILTRPDGGMTIVVPEESRQNAAVWSYLNDMIQMGTPIDAIQVYDLRESMRNGGGPACLRLRVALNETELNAVNPKVLMNDQLFMTLNQWVDKHYRDRLAQEDLADPHLLMESRMALDELTKILGLGSVYPFQK
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: IOC4_YEAST
Sequence: MSEAIFQPTDIVLAKVKGFSAWPAMIIPNELIPDNILKTKPVSVHKGKSGSDKKANEDIDADMESEARDREQSEEEEDIEDFGESEANPEKFIIYTPVLKFRKNDTLKSTYCVKFFCDDSYIWVKPMDMKILTSEDCRKWLSGKQRKNKKLIPAYEMAMRGKNGIDIWEFVEYGSYGKPDEEEYVEEEEEENEPEKKAIRPTRSSSRQRQKRASETEKSEGGNSNKRKRVTRSTRQQAIDASEEEEEEEEEKVQEAVRKRPQRTKTKKVVVSKTKPNPKTKAKKEKPKPPKPIKYHFEDDEDWSIVGLGPQDLSIEKTMDPIAKKLSQKKNLEKHVEIKLDLEDKLAGINKLLCDVLCSAINQAVSIKDDFEIILDELQIALDTRGSRNEFITIFQSNNSLLLNFRILFNLRKRELNKWDLWDRFQDIFKHIYSYQFIPDTEDWQLEQNMEIEEMDREKPSFSEDVKEEESKVGA
What is the function of this protein?
Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA.  The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing.
What are the official names of this protein?
ISWI one complex protein 4.
Protein: KAD_BORP1
Sequence: MRLILLGPPGAGKGTQAAFLTQHYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGGLVSDDLIIGLVRDRLTQPDCANGYLFDGFPRTIPQADALKSAGIALDYVVEIEVPESDIIERMSGRRVHPASGRSYHVRFNPPKAEGVDDVTGEPLVQRDDDREETVRHRLNVYQNQTRPLVDYYSSWAQSDAAAAPKYRKISGVGSVDEIKSRLSQALQS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMPD_SYNY3
Sequence: MQTLKSQRAMPTATPSDQKTTAFLTIENVSKVYPTAKGPYTVLENVNLTVNEGEFICVIGHSGCGKSTLLNMVSGFASPTDGSVQVGGKIITEPGPDRMVVFQNYALLPWLTALENVYIAVDAVHSQKTEAEKRAIAKDHLAMVGLTDSMDKKPGQISGGMKQRVSIARALAIRPEVLILDEPFGALDAITKEELQEELLQIWNDHRCTVLMITHDIDEALFLADRLVMMTNGPHANIGEIMTIPFSRPRDRDRIMEDPTYYQLRNYALDFLYNRFAHDDVA
What is the function of this protein?
Part of the ABC transporter complex CmpABCD involved in bicarbonate transport.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Bicarbonate transport ATP-binding protein CmpD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Nitrate/nitrite/cyanate uptake transporter (NitT) (TC 3.A.1.16) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HEM6_YERPA
Sequence: MNSPDIALIKTYLLTLQDNICAALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQAGVNFSHVSGAMLPASATAHRPELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPGEDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQIYPRYKKWCDDYFYIKHRQEARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKDWLAIKGETH
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KRT84_MOUSE
Sequence: MSCRSYRVSSGRRVGSFSSCSAMAPQHLNRFRSSSVSCRSGPGFRGLGGFGSRSVINFGSSSPRIAVGCSRPVRCGVGFGAGSGMAFGSGDGLGFRASSGVGLGFGAGGCPSYGFGGPGFGGPGFGGPGFGYRIGGIGGPSAPAITAVTVNQSLLTPLNLEIDPNAQRVKRDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCARSNLEPLFDNYITNLRRQLDVLSSDQARLQAERNHLQDILEGFKKKYEEEVVFRANAENEFVALKKDVDAAFLNKSDLEANVDTLIQETEFLKALYHEEIEMLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQYEEVARRSRADVESWYQTKYEEMRVTAGQHCDNLRSTRDEINELTRLIQRLKAEIEHTKAQCAKLEAAVAEAEQQGEAALNDAKCKLADLEGALQQAKQDMARQLREYQELMNVKLALDIEIVTYRRLLEGEEIRICEGVGPVNISVSSSRGGVLCGPELVSGSSLSHNGGVTFSTSSSIRATGGVLASSSLRAGGDLLSSGSRGGSVLVGDACAPSIPCALPTEGGFSSCSGGRGNRSSSVRFSSTTTSRRTRY
What are the official names of this protein?
Keratin, type II cuticular Hb4, 65 kDa type II keratin, Keratin-84, K84, Type II hair keratin Hb4, Type-II keratin Kb24.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: RL6_SACS2
Sequence: MQIVILREEIEIPKNVVVDLKGSIIKIKGPKGEVVKDFSFAKGIQISLDGNKIVLETTFANRRKKAVFYSIVSHIKNMITGVTKGYRYYLKIIYTHFPTSVKVVGNEVQITNLIGEKNTRRAQILEGVKVTVKGEDIVVEGPNLEAVAQTAANIESASKISGFDRRIFSDGIFIYKKEVIE
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ANCHR_MOUSE
Sequence: MESRCYGCAVKFTLFKKEYGCKNCGRAFCNGCLSFSALVPRAGNTQQKVCKQCHTILTRGSSDNASKWSPPQNYKKRVAALEAKKKSSTSHSQSLTHKDQAIAERLARLRQENKPKSVPSQAEIEARLAALKDEVQGPIPSTQEMEDRLAALQGRVPPSHTVRPAHQAPDTRTQAQQTQDLLTQLTAEVAIDENCQPRASASLQNDLNKGAARSQRTNSQGQASQSLEEEKYKLLAEAAVELQEENTRQERILALAKRLAVLKGQDPSRVTLQDYHLPDSDEDEETAIQRVMQQLTEEAALDEASGFNIPEKPAPGSRAQPCKAEMEGPQAEEEELPWCCICNEDATLRCAGCDGDLYCARCFREGHDNFDLKEHQTSPYHPRRPCQEH
What is the function of this protein?
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage.  Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis.  Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity).
What are the official names of this protein?
Abscission/NoCut checkpoint regulator, ANCHR, Zinc finger FYVE domain-containing protein 19.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody, Midbody ring. Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.
Protein: EFTU_CORDI
Sequence: MAKAKFERTKPHVNIGTIGHVDHGKTTTTAAITKVLADAYPELNEAFAFDAIDKAPEEKERGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKCDMVDDEEIIELVEMEIRELLAEQDYDEEAPIIHISALKALEGDEKWTQSIIDLMQACDDSIPDPERETDKPFLMPIEDIFTITGRGTVVTGRVERGSLKVNEDVEIIGIREKATTTTVTGIEMFRKLLDYTEAGDNCGLLLRGVKREDVERGQVVVKPGAYTPHTEFEGSVYVLSKDEGGRHTPFFDNYRPQFYFRTTDVTGVVKLPEGTEMVMPGDNVDMSVTLIQPVAMDEGLRFAIREGSRTVGAGRVTKIIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_HALH5
Sequence: MHVKKGDTVKVISGKDKGKQGVILEAYPKKDRVLVEGVNIVKKHAKPSQENPQGGILNMEAPIHVSNVLPIDPKTGEPTRVGYKVENGKKVRIAKKSGEVLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PGK_BARQU
Sequence: MGFRTLDDVDVTGKRVLVRVDFNVPMSQGKVCDETRLKRHKETLLELQKRGAKLILLSHCGRPKGQGEPEFSLRPVVRVLEKIINQPVAFAPDCVGVAAQTAIEALQNGGLLLLENVRFHPGEEKNDCSFAEALAHNGDLYVNDAFSVSHRAHASVEGITHLLPSYAGRSLQCELQALEKGLDNPKRPVVALVGGAKVSSKLFVLNHLVEKVDYLVIGGGMANSFLAAQGVHIGKSLCEHALMQTIKKVIEKAQEYQCTLLLPVDAVVGFRFEKGAPHRLYDIGDIPDDGMILDIGTRSIAHINEVIDKAATLVWNGPLGVFEMSPFDQGTIAVARHAAECSLTGKCVSIAGGGDTVFALNHAGVANDFTYLSTAGGAFLEWMEGKVLPGIFALRQA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOG1_CHATD
Sequence: MTGWKDIPPVPTAQEFIDIVLSRTQRRLPTQIRPGFKISRIRAFYTRKVKFTQETCSEKFGAIISSFPVLSDQHPFHRDLMNILYDADHFKVALGQISTAKNLIETISRDYVRLLKYAQSLYQCKQLKRAALGRMATLIKRLKDPLIYLDQVRQHLARLPDINPTTRTLLVAGFPNVGKSSFVRSVTRADTPVEPYAFTTKSLFVGHLDYKYLRYQVIDTPGILDHPLEEMNTIEMQSVTALAHLRAAVLYFMDISEQCGFSLKAQINLFKSIKPLFANKMVFIVLNKMDIKKFEELDPEMQQEINDLTKSGEVEILRASCATQEGVQEVKNHVCERLLVERVSQKLKAGTHSNGNIGTRLQEVMARIHVATPMDGTTRETFIPEAVKNLKKYDKNDPNRRVLARDIEEANGGAGVFNVDLRKDWILENPEWKYDKIPEIFDGKNVYDYIDPDIDAKLQALEEEEERLEKEGFYDEDDDLPDEEEEEILQKAEYIREQHALIRNEAKMRKSLKNRAIIPRKAVKKPLSQLEDHLDQLGVDTEAIGLRARAQTAQSSRGRSLVRSRGTTADPDAMDIDDGAASAKERLARSRSRARSVAATNRLQDGVQGTTLRSKAERQAKLAQRKMNRMARQGEADRHIHASMPKHLFSGKRTIGKTDRR
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Nucleolar GTP-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HIS6_LACLS
Sequence: MLTKRIIPCLDIKNGKVVKGINFVGLKEIGDPVEIAKIYEEQCADEIVFLDITASFEEREIIGELIGRAARELSIPLTVGGGIRSINDFRRILASGADKVSINSAAIENPELIHQAANEFGVQCVVVAIDAKANESGSSFEVYIKGGRENTGIDLVEWAKKCEKLGAGEILLTSMDKDGTKTGYDLKMLNAVCSAVNIPVIASGGCGSISDIIEVFEKTKSDAALFASLFHYGEATVDEVKEELIKNRIPARIIKKEII
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR8_METTH
Sequence: MAIHPVEFRYGTPEMRVIWEAENKLQKMLDVEAALAQAEGELGIIPAEAASEIVRKASTEFVTLERVNEIERDTKHDIASLVKALAEQCEGDAGEYVHFGATSNDIVDTSNSLLLRDSISVLRDKLTRVLEVLLALADENRDRVCIGRTHGQHALPTTYGMKFAIWADEIHRQLERLDACSERLCVGMMTGAVGTTAALGEEGLEVHERVSEILGLRPVLISNQVVQRDNHAEFIMVLANIATTLDKIALEIRNLQRTEIMEVGEKFDPEKQVGSSTMPHKMNPITAERICGIARVIRSYVVAALENNPLWHERDLTNSSSERIILPEACILTDYILKLTLDVLCNLVFYPENIKRNLEFTGGLIMAERLMAELTRRGMGRQTAYAAVRQCAIEASRTGRSLRDVVLERSEIMDYLTVEDLEEIMNPETYIGSARRMVERVLEESQKWL
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: RLMKL_SALTI
Sequence: MNSLFASTARGLEELLKIELEKLGAVGCQVVQGGVHFQGDTRLIYQSLMWSRLASRIILPMGECKVYSDLDLYFGVQAINWTEIFNPGATFAVHFSGLNDTIRNSQYGAMKVKDAIVDAFTRKNLPRPNVDRESPDLRINVWLNKETASIALDLSGDGLHLRGYRDRTGLAPIKETLAAAIVMRSGWQPGTPLLDPMCGSGTLLIEAAMWATDRAPGLHRGHWGFSGWAQHDEAIWQEVKAEAQTRARKGLAEYSSHFYGSDSDARVIERARSNARRAGIGELITFEVKDVAQLSNPLPKGPYGTVISNPPYGERLDSDPALIALHSLLGRTMKNQFGGWNLSLFSASPDLLGSLQLRADKQFKAKNGPLDCVQKNYHIAETTADSKPATVAEDYANRLRKNLKKLEKWARQEGIECYRLYDADLPEYNVAVDRYGDWAVIQEYAPPKTVDAQKARQRLFDIIAATLSVLGIPPNKLVLKTRERQKGKNQYQKMSEKGEFLEVSEYNARLWVNLTDYLDTGLFLDHRIARRMLGEMSKGKDFLNLFSYTGSASVHAGLGGARNTTTVDMSRTYLEWAERNLRLNGLSGRAHRLIQADCLGWLREANEQFDLIFIDPPTFSNSKRMEESFDVQRDHVALMKDLKRLLRKGGTIMFSNNKRGFRMDLEGLAELGLTAQEITQKTLSPDFARNRQIHNCWLIRAA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_SHEB2
Sequence: MKTPIELKILDSRIGSEFPLPAYATPGSAGMDLRAMIDTTLTIAPGETVLIPTGIAIHVADPGLAAVILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRSDSPFALEIGDRLAQLVFVPVVQAQFKLVDEFDSSDRGEGGFGHSGTK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: Y2637_MYCTO
Sequence: MDVEALLQSIPPLMVYLVVGAVVGIESLGIPLPGEIVLVSAAVLSSHPELAVNPIGVGGAAVIGAVVGDSIGYSIGRRFGLPLFDRLGRRFPKHFGPGHVALAERLFNRWGVRAVFLGRFIALLRIFAGPLAGALKMPYPRFLAANVTGGICWAGGTTALVYFAGMAAQHWLERFSWIALVIAVIAGITAAILLRERTSRAIAELEAEHCRKAGTTAA
What are the official names of this protein?
Uncharacterized membrane protein MT2715.
What is the protein family that this protein belongs to?
Belongs to the DedA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VM3M1_NAJMO
Sequence: MIQALLVAICLAVFPYQGSSIILESGNVNDYEVVYPQKVPALSKGGVQNPQPETKYEDTMQYEFHVNGEPVVLHLERNKGLFSEDYTETHYAPDGREITTSSPVQDHCYYHGYIQNEADSSAVISACDGLKGHFKHQGETYFIEPLELSDSEAHAIYKDENVEEEEEIPKICGVTQTTWESDEPIEKSSQLTNTPEQDRYLQAKKYIEFYVVVDNVMYRKYTGKLHVITRRVYEMVNALNTMYRRLNFHIALIGLEIWSNGNEINVQSDVQATLDLFGEWRENKLLPRKRNDNAQLLTSTEFNGTTTGLGYIGSLCSPKKSVAVVQDHSKSTSMVAITMAHQMGHNLGMNDDRASCTCGSNKCIMSTKYYESLSEFSSCSVQEHREYLLRDRPQCILNKPSRKAIVTPPVCGNYFVERGEECDCGSPEDCQNTCCDAATCKLQHEAQCDSGECCEKCKFKGAGAECRAAKNDCDFPELCTGRSAKCPKDSFQRNGHPCQNNQGYCYNGTCPTLTNQCATLWGPGAKMSPGLCFMLNWNARSCGLCRKENGRKILCAAKDVKCGRLFCKKKNSMICHCPPPSKDPNYGMVAPGTKCGVKKVCRNRQCVKV
What is the function of this protein?
Snake venom zinc metalloproteinase that inhibits platelet aggregation by cleaving platelet glycoprotein Ib alpha (GP1BA) at Glu-298/Asp-299, and abolishes binding of von Willebrand factor (VWF) to GPIBA.  Cleaves P-selectin glycoprotein ligand-1 (PSGL-1/SELPLG) at Tyr-51/Asp-52, and completely abolishes the binding of PSGL-1 to P-selectin.  Anionic amino acid sequences containing sulfated tyrosines are needed for cleavages.  Inhibits the thrombin-induced platelet aggregation, and the thrombin-induced release of ATP and ADP.  Has lectin activity (inhibited by heparin).
What are the official names of this protein?
Snake venom metalloproteinase-disintegrin-like mocarhagin, MOC, Mocarhagin-1, SVMP, Zinc metalloproteinase mocarhagin.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SECB_SALPB
Sequence: MSEQNNTEMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASSQLADDVYEVVLRVTVTASLGEETAFLCEVQQAGIFSISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEEHQDA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_METCA
Sequence: MTSAELRARFLKFFADRGHTVVASSSLVPVNDPTLLFTNAGMVQFKDVFLGREHRPYVRAASAQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKREAIVYAWEFLTEVLMLPPERLWITVYAEDKEAERIWLEEVGVDPGRFTRIATSDNFWSMGDTGPCGPCSEIFYDHGPSVAGGPPGTPEEDGDRYVEIWNLVFMQYERAGDGTLTPLPKPSVDTGMGLERLAAVMQRVRNNYDIDLFRNLVKAAAELAGTTDLAQSSLRVIADHIRSCAFLVTDGVLPSNEGRGYVLRRIIRRAIRHGYKLGIREPFFYKLVGPLCAEMGQAYPELVEARPRVEQVLDKEEERFAETLEQGMKILDVAIRDLGSPVISGDTAFQLYDTYGFPVDLTADVAREHGLQVDMAGFERAMEAQRERARAASHFSVDYSQEIHLDVACEFTGYRNAVEDTRIVALLRDGQAVDRLEAGEDGVVVLEKTPFYAESGGQVGDRGVIRSDSAVFEVADTRKQGSDLILHRGKLREGALLRGAVCRAEVEQSLRLATALNHSATHLLHAALRRVLGEHVTQKGSLVDPERLRFDFSHFEPVSPEQLDEIERLVNREIRRNAEVTAEVMAKDAAMRLGAMALFGEKYGDDVRVLRIGDFSTELCGGIHARRAGDIGLFKIVSESGVAAGVRRIEAVTGAAAVEAVEATERLLRRLAERMKAGRDTLEERLDQMFEKNRALERELERLKAKTAGAAGADLASRAVDIAGVKVLAARVDEADARMLRELVDQLKDRLGSAAIVLAAVEGGKVSLVAGVTRDQTGHIRAGDLVNSVATRIGGKGGGRPDLAQAGGNRPEELQGALDGVPEWVRRMLNA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.