PharMolix/UniProtQA huggingface dataset:
Protein: KCNJ2_RAT
Sequence: MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKESKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHCYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
What is the function of this protein?
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues.  Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.  Can be blocked by extracellular barium and cesium (By similarity).
What are the official names of this protein?
Inward rectifier potassium channel 2, Inward rectifier K(+) channel Kir2.1, IRK-1, RBL-IRK1, Potassium channel, inwardly rectifying subfamily J member 2.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor.
Protein: G3BP1_MOUSE
Sequence: MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYAHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQTVSNDLEEHLEEPVVEPEPEPEPEPEPEPVSDIQEDKPEAALEEAAPDDVQKSTSPAPADVAPAQEDLRTFSWASVTSKNLPPSGAVPVTGTPPHVVKVPASQPRPESKPDSQIPPQRPQRDQRVREQRINIPPQRGPRPIREAGEPGDVEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFFQNFGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGAVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGPSGGMRGPPRGGMVQKPGFGVGRGITTPRQ
What is the function of this protein?
ATP- and magnesium-dependent helicase that plays an essential role in innate immunity.  Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS.  Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA.  In addition, plays an essential role in stress granule formation.  Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends.  Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency.  Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.  Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510).  Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510).
What are the official names of this protein?
Ras GTPase-activating protein-binding protein 1, G3BP-1, ATP-dependent DNA helicase VIII, GAP SH3 domain-binding protein 1, HDH-VIII.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Perikaryon. Cytoplasm, Stress granule. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells. Cytosolic and partially nuclear in resting cells. Recruited to stress granules in response to arsenite treatment. The unphosphorylated form is recruited to stress granules. HRAS signaling contributes to this process by regulating G3BP dephosphorylation.
Protein: PPIL1_SCHPO
Sequence: MANVELQTSLGKILIELYTEHAPKTCQNFYTLAKEGYYDGVIFHRVIPDFVIQGGDPTGTGRGGTSIYGDKFDDEIHSDLHHTGAGILSMANAGPNTNSSQFFITLAPTPWLDGKHTIFGRVVSGLSVCKRMGLIRTDSSDRPIEPLKIIKAVAL
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase ppi1, PPIase ppi1, Cyclophilin ppi1, Rotamase ppi1.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
Protein: TRPF_DECAR
Sequence: MKTRIKICGLTREEDVDAAVAAGADAIGFVFYPPSPRYVSPQRAAELVKRIPPFVDVVGLFVNEAPEVVRIACEALPINVLQFHGDEDAAYCSQFARPYLRAARVRPGLDLVEFAGSFPDARGLLLDAFVEGYGGGGHVFDWTLIPPNLPSYLVLSGGLTADNVGDAVRRVRPVAVDISSGVEASKGIKDHSKIAAFVAAVRKADESI
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: SUFS_YERPG
Sequence: MNFPIERVRADFPLLSRQVNGQPLVYLDSAASAQKPQAVIDKELHFYRDGYAAVHRGIHSLSAEAIQQMEAVRTQVADFIHAASAEEIIFVRGTTEAINLVANSYGRHFLAAGDSIIITEMEHHANIVPWQMLAQDLGVEIRVWPLTATGELEITALAALIDDTTRLLAVTQVSNVLGTVNPIKDIVAQAKAAGLVVLVDGAQAVMHQPVDVQALGCDFYVFSGHKLYGPSGIGILYGKSALLQQMPPWEGGGAMIKTVSLTQGTTFADAPWRFEAGSPNTAGIMGLGAAIDYVTELGLLPIQQYEQSLMHYALAQLSQIKSLTLYGPTERAGVIAFNLGQHHAYDVGSFLDQYGIAIRTGHHCAMPLMAFYQVPSMCRASLALYNTREDVDRLVAGLQRIEKLLG
What is the function of this protein?
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation.  Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine.  Selenocysteine lyase activity is however unsure in vivo.
What are the official names of this protein?
Cysteine desulfurase, Selenocysteine beta-lyase, SCL, Selenocysteine lyase, Selenocysteine reductase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAA_SHIB3
Sequence: MKYDTSELCDIYQEDVNVVEPLFSNFGGRASFGGQIITVKCFEDNGLLYDLLEQNGRGRVLVVDGGGSVRRALVDAELARLAVQNEWEGLVIYGAVRQVDDLEELDIGIQAMAAIPVGAAGEGIGESDVRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_BUCA5
Sequence: MYNKTLRIATRKSPLALKQTKYVQKKILSLYPDLNIKLVPIVTHGDNILNKSLSKIGGKGLFIKELELALLENKADIAIHSMKDLPVKITKELCLVSICKRGNALDSLVSNNYQSINQLPKGAIVGTSSLRRQCQLITYRPDLIISPLRGNIETRIAKLDQGKYDAIILATEGLNRLRLKNRITQIIPAELSLPSCGQGAIGIQSRLHDKKVLFFLSRLNHINTFIEINAERAFCRKLESGCQIPIGSYAILKKNKIWLRGLVGSPNGKIILKGERIGCYNTGEKMGYSLADELLKNGAKNILNNLHIKQSYCI
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: IRC3_YEAST
Sequence: MTSTLATRLSTYSISLILQRIKIIKRCYSAPVLRDYQQDAIDACVNSIRQGTKRIGVSLATGGGKTVIFSNLINQLRQNYFKERQGNFKSLILVHRRELALQATATLKKIFPDLKVHIEMGKYDCDIEDSDVIVASVQTLIRRLHKYDTNSVNLIIIDEAHHSVANSYRSILDHFKASTAETKIPVIGFSATFERADKRALSMVMDKIVYHRGILEMIDDKWLCEAKFTSVKIEADLSDVKSTADDFQLAPLSSLMNTKEINEVILKTYLHKKQEKSLKSTLLFGVDKAHVQSLHKLFKDNGINTDYVTSDTKQIERDNIIQKFKNGETEVLMNCGIFTEGTDMPNIDCILLCRPTKSRSLLIQMIGRGLRLHHSKDHCHIIDFIGASSVGVVSAPTLLGIRSDDIEFDDATVEDLKAIQGEIIAKQQKIDERLRALFQTDEAAMENVTERNSVADWIHSANSVDLTLCSFDSFRNFTQSNNSYPSGKEFDEASEAVKEMELLMNSQYPWVKFASNAWGLPLKGKNHLRIYKEKSEDKLSMVYHLKMYRQLPCFITNKYADYVPKSIIKDANLWNVMSKVEKIINTLNSDLEGQTMQYQAISSKYSKWRQTVPTSKQRDFVFRKLKKVYGESSKDFIRLSLDDVTTYVNTKMTKGDASNLIFASSLAPVYPLKSLLRILEYQKRRSFIK
What are the official names of this protein?
Putative ATP-dependent helicase IRC3, Increased recombination centers protein 3.
What is the protein family that this protein belongs to?
Belongs to the helicase family. IRC3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SEC24_ASPCL
Sequence: MAAPQGGYPPQEGYGQPGDYGSPTQQQPGVVAGAAHQGHAGGKKKRAYAGEAFGFGSGANAALGGQPPAGGSYGVYPPQPQAAGYQQPVYGADPHQMNAAAPGYATPASPGVAQMTQQFGAMGMTDPHLMPPQPQQAAVTPQAPRPVPLNQLYPTDLLTQPFNVAELDYPPPPIVLPPGTSVYPSPQANCPPTYVRSTLNAVPTTHSLLKKSKLPFALVIQPYAALHDAEDPIQVIPDQVISRCRRCRSYINPFVTFMDHGHRWRCNMCNLTNDVPQAFDWDSALQKPADRSLRPDLNHAVVEFVAPQEYMVRPPQPLVYLFLIDVSYASVTNGLLATSARCIKESLDRIPNADRRTRLGFIAVDSSLHYFSIPRDGSENSDPRMLVVSDLEEPFLPIPGDLLVTLSECRENIETFLDKLQEMFQNTQNNGCAMGSALRAGYKLISPVGGKMTVLSSSLPNIGHGALTMREDKKVLGTSKESSLLQTANSFYKSFAVECSKAQVSVDMFLFSSQYQDVASLSNLPRYTGGQTYFYPGWNAARPEDAIKFAREFSEYLSSEIGLEAVLRVRATTGLRMNTFYGNFFNRSSDLCAFPAFPRDQAYVVEVAIDETVTKPVVCLQTAVLHTTCNGERRIRVLTLALPTTQNLADVYASADQQAIATYFSHKAVERALSSGLEPAREALQAKAVELLSTYRKELAGGSVSGGGLQFPANLRGLPVLFLALIKNLGLRKSAQIPTDMRSAALCLLSTLPLPLLMQYIYPKMYSLHDMPDNAGLPDEQTGEIVLPPPVNLSSERIVPYGLYLIDDGQTQFLWVGRDAVPQLLLDVFGLADRTQLRVGKQNLPELDNDFNQRVRAVIEKSRDHRSKGVGSIVVPHLYVVKEDGEPGLRLWAQTMLVEDRADQSVSLVQWMGSLREKV
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein sec24.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: IF3_BARQU
Sequence: MTPTQKDGPRSNQDIRVPCVQLINDEGQHQGVVATQEALAMAAEVGLDLVEIVPNTEPPVCKIIDLGKLKYQTQKKAAEIRKKQKVIEIKEIKMRPNVDVHDYEVKLKAIHRFIGNGDKVKITLRFRGREMAHQDLGLKLLQRVKEDTSEIAKIEAEPKLEGRQMMMVIAPK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_GLOVI
Sequence: MDERQVERLSGHGVAEIFPGGAEALTRRLADAETARMPLRVKLGIDPTRPDLHLGHTVVLRKLREFQDLGHTAILLIGGFTAQIGDPTGKSEARPRLSAAEVEEYAETYLDQARLILNFDTLEVRNNTEWLSGLDLAAIIKLLASTSVAQMLAKEDFGQRYEAGTAIYLHEFLYPLMQGYDSVALDADIELGGTDQRFNLLMGRNLQELFGKKPQLALTVPLLVGLDGVKKMSKSLDNYVGVTEDPLTMYSKLEKTPDALVETYFELLTDLSVSALSANPRERQKRLALAVTGWLHSPEQALRAQEAAAAMVTGSGGTGADLEAVPEFSLTEIAFPVRLANLLKAAGLCPTVSEGMRQIKNGAVRLNQERITDPNCGFAEAAELTGAVLQVGKKHFRRLVPS
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_GEOKA
Sequence: MSKQKDKERIHEKRRAKFQELQNKIGITFRNEKLLIQAFTHSSYVNEHRRRLHEDNERLEFLGDAVLELTVSQYLFQKFPHMSEGQLTKLRAAIVCEPSLVKFANALSFGELVLLGKGEELTGGRTRPALLADVFEAFIGALYLDQGMDAVIRFLEKTMFPKIDEGAFSHVMDFKSQLQELVQRDGSGTLEYAILEEKGPAHNKEFVARVALNGQELGIGVGRSKKEAEQHAAQMALETLRAADQQ
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GC_GAHVG
Sequence: MLTPRVLRALGWTGLFFLLLSPSNVLGASLSRDLEHPILSFDPSNISINGAPLTEVPHAPSTESVSTNSESTNEHTITETTGKNAYIHNNASTDKQNANDTHKTPNILCDTEEVFVFLNETGRFVCTLKVDPPSDSEWSNFVLDLIFNPIEYHANEKNVEAARIAGLYGVPGSDYAYPRQSELISSIRRDPQGTFWTSPSPHGNKYFIWINKTTNTMGVEIRNVDYADNGYMQVIMRDHFNRPLIDKHIYIRVCQRPASVDVLAPPVLSGENYKASCIVRHFYPPGSVYVSWRQNGNIATPRKDRDGSFWWFESGRGATLVSTITLGNSGIDFPPKISCLVAWKQGDMISTTNATAIPTVYHHPRLSLAFKDGYAICTIECVPSEITVRWLVHDEAQPNTTYNTVVTGLCRTIDRHRNLLSRIPVWDNWTKTKYTCRLIGYPFDEDKFQDSEYYDATPSARGTPMVITVNGSFGIGCNFRVGDNHDCPMFIHSTRKIFDYNLIVM
What is the function of this protein?
May play an immunoevasive role in the pathogenesis of Marek's disease.  It is a candidate for causing the early-stage immunosuppression that occurs after MDHV infection.
What are the official names of this protein?
Envelope glycoprotein C homolog, A antigen, Glycoprotein A, GA, Secretory glycoprotein GP57-65.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein C family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Single-pass membrane protein. Note=Predominantly secreted. Secreted, but a small amount of mature GP57-65 is anchored in the plasma membrane or held by other interactions.
Protein: Y1530_METJA
Sequence: MIIRKFSSKDLDAVEEIEREAFKTPYPTSLILGFWSMYPNCFYVAEIDGRVVGYILGSMDWGNGHIISLAVKKECRGLGIGTALLKTLENYYFNIANCNYIVLEVRVSNVLARRFYYRMGYRDRKLLPKYYEDGEDAILMIKKKPNAKGPLIITLW
What are the official names of this protein?
Uncharacterized N-acetyltransferase MJ1530.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDGT_GEOSE
Sequence: MRRWLSLVLSMSFVFSAIFIVSDTQKVTVEAAGNLNKVNFTSDVVYQIVVDRFVDGNTSNNPSGALFSSGCTNLRKYCGGDWQGIINKINDGYLTDMGVTAIWISQPVENVFSVMNDASGSASYHGYWARDFKKPNPFFGTLSDFQRLVDAAHAKGIKVIIDFAPNHTSPASETNPSYMENGRLYDNGTLLGGYTNDANMYFHHNGGTTFSSLEDGIYRNLFDLADLNHQNPVIDRYLKDAVKMWIDMGIDGIRMDAVKHMPFGWQKSLMDEIDNYRPVFTFGEWFLSENEVDANNHYFANESGMSLLDFRFGQKLRQVLRNNSDNWYGFNQMIQDTASAYDEVLDQVTFIDNHDMDRFMIDGGDPRKVDMALAVLLTSRGVPNIYYGTEQYMTGNGDPNNRKMMSSFNKNTRAYQVIQKLSSLRRNNPALAYGDTEQRWINGDVYVYERQFGKDVVLVAVNRSSSSNYSITGLFTALPAGTYTDQLGGLLDGNTIQVGSNGSVNAFDLGPGEVGVWAYSATESTPIIGHVGPMMGQVGHQVTIDGEGFGTNTGTVKFGTTAANVVSWSNNQIVVAVPNVSPGKYNITVQSSSGQTSAAYDNFEVLTNDQVSVRFVVNNATTNLGQNIYIVGNVYELGNWDTSKAIGPMFNQVVYSYPTWYIDVSVPEGKTIEFKFIKKDSQGNVTWESGSNHVYTTPTNTTGKIIVDWQN
What are the official names of this protein?
Cyclomaltodextrin glucanotransferase, Cyclodextrin-glycosyltransferase, CGTase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1482_SYNP6
Sequence: MIITIDALLDAAQLNKIQSSLQTAEFIDGRATAGWHAQLVKQNQQLSRTSTLAKSLQEIVQTALQNNALFEAAAYPQRVHSLLFSRYEPGMEYGRHVDNALMGSGDRRDRADLSFTLFLSDPDRYIGGALVIEGACDEQAYRLPAGSLLLYPSSTLHRVDPVEQGYRFACVGWVQSWIRDPAKRELLFDLDTARRSLFTREGKSIEFDLLSKTYANLLRRWSE
What are the official names of this protein?
PKHD-type hydroxylase syc1482_d.
Protein: GLND_BRUA1
Sequence: MSAHDLKLEEIVNAETLRRKLNELADTADESYTSLPMRKVVLQTLKDALASGRANAEDMLMKDGGGTLCAKRLCYLMDTLIDILFEFATTRAYPTRNPSKAENMALVAVGGYGRGGLAQGSDIDLLFLLPYKQTPWGEQVVEYTLYMLWDMGLKVGHSTRNIDECIRLAREDMTIRTALLDARFLTGDKDLFRTLEIRFEEEIVKGTEPEFIQAKLAERDARHRKAGETRYLVEPNVKEGKGGQRDLHTLFWITKYFYRVKTKEELVKLGVLSRAELKLFNKAEDFLWAVRCHMHFATLKAEERLSFDIQPEIAQRLGYTAHPGQNYVERFMKHYFLVAKDVGDLTRIICAALEEQQAKHVPGFNRIFLTFSRRKRKLSDDGAFISENHRINIARPDIFRQDPVNMIRLFHLADRHGLEFHPEAMQSLTRSLKLINADLRENPEANRLFLEILTSPRNPELILRRMNESGVLGKFIPDFGKIVAMMQFNMYHHYTVDEHLLRCIAVLSEIEHGELKTEHPLSNHLITTIKRDRNLLYVTLLLHDIAKGRPEDHSIAGARIARRLCPRFGLTPSETETVEWLVREHLTMSMVAQSRDLNDRKTIIDFADTVQTMERLKLLLILTVCDIKAVGPGIWNGWKGQLLRTLFYETELVLTGGFSELSRAARDKQAREALAERLSDWPKEERDAYLALPYTNYFLTVSLDDQVRHAHFIRDADQQGRALVTMAKPHAFEAVTEITVLAPDHPRLLSVITGACAAAGGNIVDAQIFTTSDGRALDTILISREFDTDDDERRRAERVGKVIEDVLSGKAHLPDMLAKRTKPKKAARAFKVEPRVEINNTLSNKFTVIEVEGLDRPGLLSELTGLISDLSLDIASAHITTFGEKVIDSFYVTDLVGHKISNATRQGNIKRKLLALLGAENGARTNGRSPQAAA
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: ECFA1_STRP2
Sequence: MKSIIDVKNLSFRYKENQNYYDVKDITFHVKRGEWLSIVGHNGSGKSTTVRLIDGLLEAESGEIVIDGQRLTEENVWNIRRQIGMVFQNPDNQFVGATVEDDVAFGLENQGLSRQEMKKRVEEALALVGMLDFKKREPARLSGGQKQRVAIAGVVALRPAILILDEATSMLDPEGRRELIGTVKGIRKDYDMTVISITHDLEEVAMSDRVLVMKKGEIESTSSPRELFSRNDLDQIGLDDPFANQLKKSLSQNGYDLPENYLTESELEDKLWELL
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RPO5_THEVO
Sequence: MAKFNVLDHNLVPEHHIVSEEEEKTILKELGIEKEFLPRISPNDPVIKALEAIHGKIKDGTVIKIIRNSPTMGHSVYYRVVASEVFK
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo5, DNA-directed RNA polymerase subunit H.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_SHIFL
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVDLRQQSFTIEGLAVGVIRNGDWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: WRT4_CAEEL
Sequence: MRFSLLALVLLSSSYKFTYGSECGDSTIPYSLEVLSSGQPILGCARPTCFGWHSNGHQLPTNAKFFRIDQQSDGFLRDDPLAIHTFDAADPRVYAQQQASCEQEFQSLSCNPEDQWVGGIAPVMNASTTKIVAYKCCTYAPLRASIDRGVATVSGGQIVVGGEIFADNKPYAFDYISNVEKKIDSEGEIFYEVNIKRFSCLDLQKVDRSVPEILNSENTIRHVNGHRFVVHQAPTVDVETPVETGQLVVPQGVQNGQEVIIEEIVAQEGFVQETNPQPPPPPGQQGGFVQPQGFQPQGGFQPQGFQPQGFQPQAFQPQVVQNPVPAAPAGYAPMGFAPSGLQLYYCFPGDAMVNVYNGGFKRMDELAVGDWVQALDKNGSQVTFIPVQYWLHRDPKQVADFVEFTLDNGETFSLTEKHLVFVTQCSVPYSEDENINANPVPAERVNIGDCFYIAHRKKSQMYQRVKVLDINIVQKTGIYSPMTSRGHLLVDRIHASCHSETDNYSLQNTFFTNVLRWKSQIRNYFWTVEDSTNEDNIGYGLNGVMAVLDIVIPSKLM
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.
What are the official names of this protein?
Warthog protein 4, Protein M75.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Warthog protein 4]: Secreted. Cell surface. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. SUBCELLULAR LOCATION: [Warthog protein 4 N-product]: Cell membrane; Peripheral membrane protein; Extracellular side. SUBCELLULAR LOCATION: [Warthog protein 4 C-product]: Secreted, extracellular space. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells.
Protein: PG163_VACCW
Sequence: MDAAFVITPMGVLTITDTLYDDLDISIMDFIGPYIIGNIKTVQIDVRDIKYSDMQKCYFSYKGKIVPQDSNDLARFNIYSICAAYRSKNTIIIACDYDIMLDIEDKHQPFYLFPSIDVFNATIIEAYNLYTAGDYHLIINPSDNLKMKLLFNSSFCISDGNGWIIIDGKCNSNFLS
What is the function of this protein?
Mildly affects the expression of MHC class II molecules on the surface of host antigen presenting cells (APCs).
What are the official names of this protein?
Protein OPG163.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG163 family.
Protein: ARPC4_SCHPO
Sequence: MSNTLRPYLNAVRSTLTASLALEEFSSEIVERQSQPEVEVGRSPEILLKPLVVSRNEQEQCLIESSVNSVRFSIRIKQVDEIERILVRKFMQFLMGRAESFFILRRKPVQGYDISFLITNYHTEEMLKHKLVDFIIEFMEEVDAEISEMKLFLNGRARLVAETYLSCF
What is the function of this protein?
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the mother actin filament (By similarity).
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 4, Arp2/3 complex 20 kDa, p20-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch.