PharMolix/UniProtQA huggingface dataset:
Protein: NANA_ECOSM
Sequence: MATNLRGVMAALLTPFDQQQALDKASLRRLVQFNIQQGIDGLYVGGSTGEAFVQSLSEREQVLEIVAEEAKGKIKLIAHVGCVSTAESQQLAASAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLSLDQINTLVTLPGVGALKQTSGDLYQMEQIRREHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALKEGDIQTAQKLQTECNKVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFGPVDEKYLPELKALAQQLMQERG
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RASA3_MOUSE
Sequence: MAVEEEGLRVFQSVRIKIGEAKNLPSYPGPNKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQRYHNRDTWFQLQHVDADSEVQGKVHLELRLSEVITDTGVVCHKLAARIFECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKKKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRLPLKILRHSSSYEAWYFLQPRDNGNKSLKPDDLGSLRLNVVYTEDHVFSSEYYSPLRDLLLKSADVEPVSASAAHILGEVCRDKQEAAIPLVRLLLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLTSKCIDETMKLAGMHYLHVTLKPTIEEICQSHKSCEIDPVKLKDGENLENNMESLRQYVDRIFTVITKSGVSCPTVMCDIFFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTIQTLGSLSKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSIEQPILLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKGDQPLCNIPIENILAVERLEEESFRMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVFHPSAYLNGHWLCCRASSDTAAGCTPCTGGLPANIQLDIDGDRETERIYSLFNLYMGKLEKMQEACGSKSVYDGPEQEEYSTFVIDDPQETYKTLKQVIAGVGTLEQEHAQYRRDKFKKTRYGSQEHPIGDKSFQNYIRQQSEISTHSI
What is the function of this protein?
Inhibitory regulator of the Ras-cyclic AMP pathway.  May bind inositol tetrakisphosphate (IP4).
What are the official names of this protein?
Ras GTPase-activating protein 3, GAP1(IP4BP), GapIII, Ins P4-binding protein.
Protein: NHAA1_ERYLH
Sequence: MVDPIRSPLSRAFAPVRALFVSDASAGILLILVAAAAMIVANSPLAGAYEEMFYGDLAWTPIAKLDDLHLWINDGLMAIFFFVVGLEVKRELICGQLSSPEQRTLPVLAAIAGMAVPAIVYVGVVGTDSALVRGWAIPAATDIAFAMGVLGLLGSRVPASLRLFLLTVAIVDDIGAVLVIAAFYTANLKVMWLVIALGIFGVMVGMNKFGVDRIWPYILVALVLWVAVLFSGVHATIAGVMAALTIPMRRKDGHSLLEKLEHGLAPWSAYLVVPIFGFANAGVNLSGMGLDAVLAPLPLAIAAGLVVGKQLGIFGIIVAAVKLGIAKAPANANWIEIWGVSILTGIGFTMSLFISGLAFTDSRLLIDEAKIGILGGSLISAILGYTILRLTTTHPEERPPQTVTP
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ABFC_ASPFC
Sequence: MTTFTKLSEQETPSISVHASRRISKINPNIYAGFTEHMGRCIYGGIYDPGNPLSDENGFRKDVLEALKELNIPVIRYPGGNFTATYHWIDGVGPKDQRPARPELAWLGTETNHFGTDEFMKWCELLGTEPYFCLNFGTGTLDEALAWVEYCNGTKDTYYANLRRKNGREEPYNIKYWALGNEVWGPWQVAQMTKEEYAHKAYQWAKALKLLDPSLKLILCGQDGTASWDYYTLKQCLLPAHSPLSTSTVPLIDMHSIHMYTCGSTHLPNVTAPLAAERAIEITSSLIDLAMIENGIPPDQPRPTICFDEWNVWDPLRAEGSKGAEESYTLSDALAVAIWLNVFVRKSKDVGMACIAQSVNVISPLMTTKDGIIKQTIWWPLYLFSKYMRGWTINAHVSCGAYEGETSPKWIRAVKDTPWLDVSATLGEDGYANVAVVNISDEKDMECKFEGATGDVTVFTVTGDSVSACNMKGKEEVGLTESTWDGKGAYKFPRHSLTLLRWKAE
What is the function of this protein?
Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose.  Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides (By similarity).
What are the official names of this protein?
Probable alpha-L-arabinofuranosidase C, ABF C, Arabinosidase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 51 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DBH_STRP1
Sequence: MANKQDLIAKVAEATELTKKDSAAAVDAVFSTIEAFLAEGEKVQLIGFGNFEVRERAARKGRNPQTGAEIEIAASKVPAFKAGKALKDAVK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.  Seems also to act as a fortuitous virulence factor in delayed sequelae by binding to heparan sulfate-proteoglycans in the extracellular matrix of target organs and acting as a nidus for in situ immune complex formation (By similarity).
What are the official names of this protein?
DNA-binding protein HU.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: NUCS_RHOE4
Sequence: MRLVIARCRVDYVGRLTSHLPTARRLLLVKADGSVSIHADDRAYKPLNWMSPPCWLVETTGDSDDILWVVTNKAGEELRITLEEVEHDSSYELGLDPGLIKDGVEAHLQELLAEHVETLGPGYTLVRREYMTAIGPVDLLVRDADGASVAVEIKRRGEIDGVEQLTRYLELLNRDPLLAPVTGVFAAQQIKPQAKTLANDRGIRCLVLDYEALRGTESTEFRLF
What is the function of this protein?
Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
What are the official names of this protein?
Endonuclease NucS.
What is the protein family that this protein belongs to?
Belongs to the NucS endonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD20_HUMAN
Sequence: MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
What is the function of this protein?
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111).  Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602).
What are the official names of this protein?
B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1.
What is the protein family that this protein belongs to?
Belongs to the MS4A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor. Note=Constitutively associated with membrane rafts.
Protein: GSTD7_DROME
Sequence: MPNLDLYNFPMAPASRAIQMVAKALGLELNSKLINTMEGDQLKPEFVRINPQHTIPTLVDNGFVIWESRAIAVYLVEKYGKPDSPLYPNDPQKRALINQRLYFDMGTLYDALTKYFFLIFRTGKFGDQEALDKVNSAFGFLNTFLEGQDFVAGSQLTVADIVILATVSTVEWFSFDLSKFPNVERWLKNAPKVTPGWEQNLESLQQGKKFLQDLQAAKEKEVKA
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028).  May be involved in detoxification (PubMed:22082028).
What are the official names of this protein?
Glutathione S-transferase D7.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Delta family.
Protein: COAD_ACTP2
Sequence: MSYTVIYAGTFDPMTNGHLDIIERASELFGQVIVAVAKNPSKQPLFSFEERTALVRQSCAHLANVQAVGFSGLLADFAKQHQAKALVRGIRGSDDIEYEIQLAQLNDKLSGRLDTVFLPPSVTWRYLSSTMVREIYRHQGDVAQFVPNAVLCALKEKE
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHEB_METBF
Sequence: MLEMTIRALIVDDSALIRKLLSDILSQDPNLRIIGTAFNGKDGLEKIKKLRPDVVLLDNIMPVFDGLKTLAWIVKECPTPVVMISAFGERAEEITLTAFEYGAVDVIQRPEGILSQNMPDMAEEICRKTRAATKANLENLECMRNRELEETDINKREKIEKHRSRKETTSFVRNVLAIGASTGGPRALEKLIGSFPADIPAAVLIVQHMPAGFTASFSKRLDSKTALRVKEAEEGDIIEEGTVLIAPGNHHMEIVQKTVKGRKEEVAHLSCSPKELGSRPSVNALFRSIAPIYGSKIVSLVLTGMNCDGADGAEQVKKMGGKIIAEAQSSCVVYGMPKEVVRRKLADFVLPLDKMAEEIVKIIS
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_PARXL
Sequence: MQTVLIALLRFYKVAVSPMLGNRCRFYPSCSDYAREAIQYHGAARGTYLAARRICRCHPFSAGGIDLVPPPTSEKR
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GPDA_MALP2
Sequence: MINNRICILGTGAWATALGSRLSLNGNTVFLWGIDNNEVNDINSGYNKKYFGNTKFSSSLSATTDLKTAIGDSKYIIFAIPSTALDSVLDKVKEFLSDKKSQVILINVVKGIDAETSQILSNKIKSKLGSHYYSRLVTLCGPSFATEVFEEKPTVINGTGKNLKIVKQVCELFNSDVFKVIPINDIVGLQVFSSLKNLLAIAVGLSQAEYTSVNTMSAILTMGIEEIQKIACKMKAKKWTIMSFCGIGDIFLTCSSTQSRNYSFGQDLLKKGVEKTIKENKKTVEGFEVYKTAKNIITKYNINAPIFSSIIEVLEGKLDPKEFSKKCLELFWNQKINK
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOA_BURCJ
Sequence: MNLAAYYPVLLFLLVGTGLGIALVSIGKLLGPNKPDVEKNAPYECGFEAFEDARMKFDVRYYLVAILFIIFDLETAFLFPWGVALRDIGWPGFIAMMIFLLEFLLGFAYIWKKGGLDWE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y355_HAEIN
Sequence: MKIRLLKPLLIVGVLLMIWQMVATLGSFPHYIFPSPQAVRQQLFTHAELLWQHTQVTLLEICLGLLLGFLFGLISALLLSFSRQISAVLLPILVISQAIPVFAIAPLLVLWFGYGMASKIVMSVLIIYFPVTAACYDGLRNTPQAWLDLAKTFNISPLRLLLKVRLPAALPAFASGLRIAVSVAPIGAVVGEWVGSSEGLGYLMIHANARMQVDLMFAALLILVSISLCLYFSIDWLLHRFIWSV
What is the function of this protein?
Probably part of a binding-protein-dependent transport system.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Probable ABC transporter permease protein HI_0355.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAPSD_HEVHY
Sequence: MGPRPILLLFLMFLPMLLAPPPGQPSGRRRGRRSGGSGGGFWGDRVDSQPFAIPYIHPTNPFAPNVTAAAGAGPRVRQPVRPLGSAWRDQAQRPAAASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRGAILRRQYNLSTSPLTSSVATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVARATIRYRPLVPNAVGGYAISISFWPQTTPTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRGADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGIAIPNDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSVTLVNVATGAQAVARSLDWTKVTLDGRPLSTIQQYSKIFFVLPLRGKLSFWEAGTTRPGYPYNYNTTASDQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLGPHSALALLEDTLDYPARAHTFDDFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL
What is the function of this protein?
Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter.  The capsid is composed of 60 copies linked to each other.  Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity).  Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry.  Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity).  Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity).  The nuclear form probably modulates host gene expression (By similarity).
What are the official names of this protein?
Pro-secreted protein ORF2, Protein ORF2, pORF2.
What is the protein family that this protein belongs to?
Belongs to the hepevirus capsid protein family.
What are the subcellular locations of this protein?
[Isoform Secreted protein ORF2]: Secreted. SUBCELLULAR LOCATION: [Isoform Capsid protein ORF2]: Virion. Host cytoplasm. Host endoplasmic reticulum. Host Golgi apparatus. Host cell surface.
Protein: PCS1_WHEAT
Sequence: MEVASLYRRVLPSPPAVEFASAEGKRLFAEALQGGTMEGFFNLISYFQTQSEPAFCGLASLSVVLNALAIDPGRPWKGPWRWFDESMLDCCEPLHKVKAEGITFGKVVCLAHCAGARVQSFRADQTTIHDFRAHLTRCASSQDCHLISSYHRSPFKQTGTGHFSPIGGYHAEKDMALILDVARFKYPPHWVPLTLLWDAMNTTDEATGLLRGFMLVSRRSSAPSLLYTVSCGHGSWKSMAKYCVEDVPNLLKDESLDNVTTLLSRLVESLPANAGDLIKCVIEVRRKEEGESSLSKEEKERLFLKEKVLQQIRDTDLFRVVHELQYPKGLCGSCSSSSDEDSLAEIAATVCCQGAAFLSGNLVSRDGFCCRETCIKCIEANGDGLKTVISGTVVSKGNEQAVDLLLPTSSSKTSLCNSNLKSKIVKYPSSTDVLTVLLLVLQPNTWLGIKDENVKAEFQSLVSTDNLPDLLKQEILHLRRQLHYLAGCKGQEACQEPPSP
What is the function of this protein?
Involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC), the heavy-metal-binding peptides of plants.
What are the official names of this protein?
Glutathione gamma-glutamylcysteinyltransferase 1, Cadmium tolerance protein, Phytochelatin synthase 1, TaPCS1.
What is the protein family that this protein belongs to?
Belongs to the phytochelatin synthase family.
Protein: RDRP_CMVB
Sequence: MAFPAPAFSLANLLNGSYGVDTPEDMERLRSEQREEAAAACRNYRPLPAVDVSESVTEDAHSLQTPDGAPAEAVSDEFVTYGAEDYLEKSDDELLVAFETMVKPMRIGQLWCPAFNKCSFISSIAMARALLLAPRTSHRTMKCFEDLVAAIYTKSDFYYSEECEADDVQMDISSRDVPGYSFEPWSRTSGFEPPPICEACDMIMYQCPCFDFNALKKPCAERTFADDYVIEGLDGVVDNATLLSNLGPFLVPVKCQYEKCPTPTIAIPPNLNRATDRVDINLVQSICDSTLPTHSNYDDSFHQVFVESADYSIDLDHVRLRQSDLIAKIPDSGHMIPVLNTGSGHKRVGTTKEVLTAIKKRNADVPELGDSVNLSRLSKAVAERFFISYINGNSLASSNFVNVVSNFHDYMEKWKSSGLSYDDLPDLHAENLQFYDHMIKSDVKPVVSDTLNIDRPVPATITYHKKSITSQFSPLFTALFERFQRCLRERIILPVGKISSLEMAGFDVKNKYCLEIDLSKFDKSQGEFHLLIQEHILNGLGCPAPITKWWCDFHRFSYIRDRRAGVGMPISFQRRTGDAFTYFGNTIVTMAEFAWCYDTDQFEKLLFSGDDSLGFSQLPPVGDSSKFTTLYNMEAKVMEPSVPYICSKFLLSDEFGNTFSVPDPLREVQRLGTKKIPYSDNDEFLFAHFMQFVDRLKFLDRMSQSCIDQLSIFFELKYKKSGEEAALMLGAFKKYTANFQSYKELYYSDRRQCELINSFCISEFRVERVNSNKQRKKHGIERRCNDKRRTPTGSYGGGEEAETKVSQTESTGTRSQKSQRESAFKSQTVPLPTVLSSGRSGTDRVIPPCERGEGTRA
What is the function of this protein?
RNA-dependent RNA polymerase which replicates the viral genome composed of 3 RNA segments, RNA1, RNA2 and RNA3.
What are the official names of this protein?
RNA-directed RNA polymerase 2a, protein 2a.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: BIOB_CLONN
Sequence: MVNRLLDKIINEGYDISYDEAVRLIDEDIDKVLQGAKKLRKVFCGKHVDLCSIINAKCGKCSEDCKFCAQSIFYNTNIKTHPLCSYDEILKLAKENELEGVHRYSLVTSGRGISGKEFEDILNIYKKLKEDTKIKLCASLGIISKYQLKKLKEAGVSRYHHNLETSREFYSKICTTHSYDERIQTIKNAKGVGLDVCSGGIIGLGESFIDRINLAFELKNLKIRSIPINILMPIGGTPLENQRKLNNEEILKTIAIFKFINPKADIRLAGGRGSLENYGEEAFLSGVSATITGNYLTTQGNGIKNDIKLLNKLGLTV
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: CSN10_CANGA
Sequence: MTDESDNYNDFMMSDEDMDSIEMEDEENDVEGDEGQRGGQEWVQNYEQGLSLWNDENYVAARQVFLKTLSMLVSEEELIEMRCKIHRQVLECWCKILMYGEPDNEQSTEIIADFRNFVELVNELHGKANCSLDLSSMFHHVTMDFMPNIYDRTFIPGITDDEESSKWAKMTFKTTILQILQGSWVCHTFPEVGLLLQQELHVLQAWIKTFDKERDLYAISESLRKDINTLNELQLILQCYIARYIEDQHLLCNEGEVFRMCLNQLDQKCNESLAVAQRSDINLILHFSKALFLILFELDQDDLGDGNKVTGSTCVRRFVTIHKFYQNIECCKEEFWECLKNLEELGTNKFRFERFMQIIVGGFVLCAMIMHRGSQTRLAGTSGNADINPFDYEQLRIAPDHIFVDKLRRIYDVFVGLQIQEMHSCLIELECIRAPLSRLFDQVCYLIQKRKLFSEIAPIYSCISIQDLRQKLQIDPSVPPTRDEILVHLMRYCMQDRGINFKLDLVADTVTFYSEQHSEPLHDAVFSETRMGHKSHKSSISKDRAIVEDIKAAHEMPEVEYAHDIGILESQVDSQSHSKSNTKSMSRHVSGHDPDSFGQDTISFFDTLRLARETYQGSNIDNSVYTIAKLTNEALQEISNDVR
What is the function of this protein?
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.  The CSN complex is involved in the regulation of the mating pheromone response (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 10.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ISPE_GEOKA
Sequence: MRLSIKAPAKINLSLDVLYKRPDGYHEVKMVMTTIDLADRIELVALPEEDAIRIVSQNRFVPDDCRNLAYQAAKLLKETFSIRQGVAISITKHIPVAAGLAGGSSNAAATLRGLNKLWQLGLTLDELAELGAKIGSDVAFCVYGGTALATGRGEIITPIPSPPPCWVVLAKPPIGVSTAEVYRNLELERVSHPDVDAMVRAIERQDYAAICRLVGNVLEEVTLKKYPEVAHIKEQMKRFGADAVLMSGSGPTVFGLIEHDSRMQRVYNGLRGFCDQVFAVRMLGERHSLD
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PGK_METMP
Sequence: MFLTLDDFELEGKTVALRVDINSPIDVNTGDILDDTRIKACSDTIKSLSEKGAKVVILAHQSRPGKKDFTTLEAHAKKLSEVLNMEVTHVDGLICASAREAILAMDNGEIILLENVRLLAEEVLSDWKSWEEITPEKQAKTVMIKKLHPFFDYFVNDAFAAAHRAQPSLVGFSYYVPMLCGRVMEKELFTLTKVLKNPERPCVFALGGAKADDSIEVLKNVLEKQTADQVLTSGVVANIFLVAKGYKIGPNENVIADMGYTNQIEIAKELISKYGDKIVVPIDAALNVDGERVEKELDLNEEITYPIHDMGEKTMKLYEEILKDAKTVVANGPAGVFENKNFLKGTEELLKSTANSKGFSVIGGGHLSAAAEVVGLAGKMDHISTGGGACIEFLAGKKLPVIEMLSKSYEKHKL
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_STACT
Sequence: MSKTVVRKNESLEDALRRFKRSVSKSGTIQEVRKREFYEKPSVKRKKKSEAARKRKFK
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RLME_SHEDO
Sequence: MSAKKRTASSARWMQEHFDDHYVKLAQKRGLRSRAAFKLEEIQQKDHLIRQGMTVVDLGAAPGGWSQVAVKLAGDNGKVIACDILPMDPIVGVDFLQGDFREENVLNALLDRVGEDKVDVVLSDMAPNMSGSDGVDQPRAMYLVELALEMCHQVLAPNGCFAVKVFQGEGFDEYIKSVKQAFKTVKTRKPDSSRARSREVYLVATGYKL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDA_STRP6
Sequence: MLFNINEKGEPLVISFAPFLSPEAIKYLQENERCSDQSQKRTAQQIEAIYTSGQNILVSASAGSGKTFVMVERILDKILRGVSIDRLFISTFTVKAATELRERIENKLYSQIAQTTDFQMKVYLTEQLQSLCQADIGTMDAFAQKVVSRYGYSIGISSQFRIMQDKAEQDVLKQEVFSKLFSEFMNQKEAPVFRALVKNFSGNCKDTSAFRELVYTCYSFSQSTENPKIWLQENFLSAAKTYQRLEDIPDHDIELLLLAMQDTANQLRDVTDMEDYGQLTKAGSRSAKYTKHLTIIEKLSDWVRDFKCLYGKAGLDRLIRDVTGLIPSGNDVTVSKVKYPVFKTLHQKLKQFRHLETILMYQKDCFPLLEQLQDFVLAFSEAYLAVKIQESAFEFSDIAHFAIKILEENTDIRQSYQQHYHEVMVDEYQDNNHMQERLLTLLSNGHNRFMVGDIKQSIYRFRQADPQIFNQKFRDYQKKPEQGKVILLKENFRSQSEVLNVSNAVFSHLMDESVGDVLYDEQHQLIAGSHAQTVPYLDRRAQLLLYNSDKDDGNAPSDSEGISFSEVTIVAKEIIKLHNDKGVPFEDITLLVSSRTRNDIISHTFNQYGIPIVTDGGQQNYLKSVEVMVMLDTLRTINNPRNDYALVALLRSPMFAFDEDDLARIALQKDNELDKDCLYDKIQRAVIGRGAHPELIHDTLLGKLNVFLKTLKSWRRYAKLGSLYDLIWKIFNDRFYFDFVASQAKAEQAQANLYALALRANQFEKSGYKGLYRFIKMIDKVLETQNDLADVEVAAPKQAVNLMTIHKSKGLQFPYVFILNCDKRFSMTDIHKSFILNRQHGIGIKYLADIKGLLGETTLNSVKVSMETLPYQLNKQELRLATLSEQMRLLYVAMTRAEKKVYFIGKASKSKSQEITDPKKLGKLLPLALREQLLTFQDWLLAIADIFSTEDLYFDVRFIEDSDLTQESVGRLQTPQLLNPDDLKDNRQSETIARALDMLEAVSQLNANYEAAIHLPTVRTPSQLKATYEPLLEPIGVDIIEKSSRSLSDFTLPHFSKKAKVEASHIGSALHQLMQVLPLSKPINQQTLLDALRGIDSNEEVKTALDLKKIESFFCDTSLGQFFQTYQKHLYREAPFAILKLDPISQEEYVLRGIIDAYFLFDDHIVLVDYKTDKYKQPIELKKRYQQQLELYAEALTQTYKLPVTKRYLVLMGGGKPEIVEV
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: RLMN_BURM7
Sequence: MAGETIVNLLDLDAEGLVAYCGSLGEKAFRAKQLQRWIHQYNAADFDGMTDLAKSLREKLKGRAVIGTPDILSDHVSADGTRKWLINVGNGNAVETVFIPEETRGTLCVSSQAGCAVNCRFCSTGKQGFSRNLSTGEIVGQLRMAEFALRASLGRAPGPNGKAERVITNVVMMGMGEPLLNYSAVVPAMRLMLDDNAYGLSRRRVTLSTSGVVPMMDRLGAELPVALAVSLHAPNDALRDELVPLNKKHPLRELMAACQRYLKVAPRDFITFEYCMLDGVNDTEAHARELLAVTRDVPCKFNLIPFNPFPESGLVRSKTEQIKRFAQVLIDAGVVTTIRKTRGDDIDAACGQLAGAVKDRTRLAERTGASKIIEVRAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_METM7
Sequence: MTCTIVVGGQWGDEGKGKIISYLCKKDNPSIIARGGVGPNAGHTVEVDGEKYGIRMVPTGFPNVNAKLAVGAGVLTDPEVLLKEIQMLEKFNVGERMIIDFRCGIIEEIHKELDKSNEHLSKEIGSTGTGCGPANVDRAMRTLKQGKDVESISKYLGDVSEAVNEALEAGYNVLIEGTQGSLLSLFYGSYPYVTSKDTNAASFAADVGVGPTKIDEVVAVFKSYPTRVGEGPFPTEMSVEEAESLGVVEYGTVTGRRRRVGYFDHELAKKVCRLNGATQIAITCLDKYDNECYGITEYEKLSEKGKAFIKEVEEKVGVKVTLISTGPELTQTIDVRNK
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.