PharMolix/UniProtQA huggingface dataset:
Protein: ATPL_MYCTU
Sequence: MDPTIAAGALIGGGLIMAGGAIGAGIGDGVAGNALISGVARQPEAQGRLFTPFFITVGLVEAAYFINLAFMALFVFATPVK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISPF_SOLUE
Sequence: MSEIRTGLGWDVHRIATGRKMILGGVTVPCEFGLEGHSDADVLAHAITDAILGAAALGDIGMHFPDSDPRWKGCDSLVFLRHARDLATQKGYRIVNVDSTIILERPKLKDFRQTIRERLAETLELDVDRVSVKFKTAEKVGPVGEGRSAESQAIVTLEK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: BRKA_BORPE
Sequence: MYLDRFRQCPSSLQIPRSAWRLHALAAALALAGMARLAPAAAQAPQPPVAGAPHAQDAGQEGEFDHRDNTLIAVFDDGVGINLDDDPDELGETAPPTLKDIHISVEHKNPMSKPAIGVRVSGAGRALTLAGSTIDATEGGIPAVVRRGGTLELDGVTVAGGEGMEPMTVSDAGSRLSVRGGVLGGEAPGVGLVRAAQGGQASIIDATLQSILGPALIADGGSISVAGGSIDMDMGPGFPPPPPPLPGAPLAAHPPLDRVAAVHAGQDGKVTLREVALRAHGPQATGVYAYMPGSEITLQGGTVSVQGDDGAGVVAGAGLLDALPPGGTVRLDGTTVSTDGANTDAVLVRGDAARAEVVNTVLRTAKSLAAGVSAQHGGRVTLRQTRIETAGAGAEGISVLGFEPQSGSGPASVDMQGGSITTTGNRAAGIALTHGSARLEGVAVRAEGSGSSAAQLANGTLVVSAGSLASAQSGAISVTDTPLKLMPGALASSTVSVRLTDGATAQGGNGVFLQQHSTIPVAVALESGALARGDIVADGNKPLDAGISLSVASGAAWHGATQVLQSATLGKGGTWVVNADSRVQDMSMRGGRVEFQAPAPEASYKTLTLQTLDGNGVFVLNTNVAAGQNDQLRVTGRADGQHRVLVRNAGGEADSRGARLGLVHTQGQGNATFRLANVGKAVDLGTWRYSLAEDPKTHVWSLQRAGQALSGAANAAVNAADLSSIALAESNALDKRLGELRLRADAGGPWARTFSERQQISNRHARAYDQTVSGLEIGLDRGWSASGGRWYAGGLLGYTYADRTYPGDGGGKVKGLHVGGYAAYVGDGGYYLDTVLRLGRYDQQYNIAGTDGGRVTADYRTSGAAWSLEGGRRFELPNDWFAEPQAEVMLWRTSGKRYRASNGLRVKVDANTATLGRLGLRFGRRIALAGGNIVQPYARLGWTQEFKSTGDVRTNGIGHAGAGRHGRVELGAGVDAALGKGHNLYASYEYAAGDRINIPWSFHAGYRYSF
What is the function of this protein?
Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.
What are the official names of this protein?
BrkA autotransporter.
What are the subcellular locations of this protein?
[BrkA autotransporter]: Periplasm. SUBCELLULAR LOCATION: [Serum resistance protein BrkA]: Secreted. Cell surface. SUBCELLULAR LOCATION: [BrkA translocator]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
Protein: HIS8_RUEPO
Sequence: MNQFTPQPGIMDIALYQGGKAHVDGVANVIKLSSNENPLGPSPAAVEAIRATAAQAHRYPSTDHAELRAAIGAVHGLDPDRIICGVGSDEVLQFVAQAYTGPGDEVIHTEHGFSMYPILARMAGATPVQVPERQRVVDVDAILAAVNDRTRLVFLANPANPTGTMISEAEVTRLADGLPGHVLLVLDGAYAEFVEGFDGGAALVSARDNVIMTRTFSKIYGLGGLRIGWGYAPREIIDVLNRIRQPFNLSTMQLAAAEAAVRDQDWVARCRDQNTTWRTWLAARLAELGVPSDVSCANFILARFADQGEAEACDLFLQSRGLIVRRVAGYNLPQALRITVGDEAGCRAVVDAVRAFKEARA
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: Y030_SIFVH
Sequence: MLIAQVIKKGWYIDFKVSSLVDIPTKYLLYTKTIGEEKYGTDAMCHIVFPLRRMEPSFIRGGYNLPTIDKRKRPNQGDGGGIRGHDIGSVWYSSIIFIRGRGGMVWGCSGTTDYMVPPVSGRRGRVYMVDAKQILKLDIDVDVNFYDPNWLLQKKLDMLHALGYQEEEAWWEYSPSGKHIHVIIVLKDPISTKELFDLQFLLGDDHKRVYFNYLRYSVMKEDAVHFNVLYTYKKSLTFSDKLKAIFRHWFKSKQYSKNLRLGQTT
What are the official names of this protein?
Uncharacterized protein 30.
Protein: PFDB_METVS
Sequence: MELPPNVQNQLMQFQQLQQQLQMIMYQKQQFETQLKEMEKAVEEMEKSTSDEVFKMAGGILVKRNKDEVKEELSEKMETMKLRVATFEKQEEKMQKRYAELQENLQKVIGQGH
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHK_RHOP2
Sequence: MSDVLSNDLMQKMDAYWRAANYLSVGQIYLQDNPLLEQPLQLEHIKPRLLGHWGTTPGLNLLYVHLNRLITEHDLDMIYIIGPGHGGPGLVANSYLEGSYTERYPAIERNRNGLQRLFRQFSWPHGVPSHVSPETPGSIHEGGELGYSLAHAYGAAFDNPDLIVACIVGDGEAETGALATSWHSNKFLNPARDGAVLPILHLNGFKIANPTVLARISRQELTDLMRGYGYEPIVVEGDEPALVHHALAAALDRALADIQAIQAAARHQGVTARPRWPMIILRTPKGWTGPKQVDGKQVEGTWRAHQVPIADFKDPAHVQLLETWLRSYRPEELFDANGKFRDELAALAPTGHCRMSANPHANGGELLQPLSLPDFRNYAVALSAPGAAKAEATRALGTFLRDVMRDNLETKNFRLFGPDETASNRLDGVLEVTDKQWMADIEDVDIALGPDGRVMEVLSEHLCQGWLEGYLLTGRHGLFSCYEAFIHIIDSMFNQHAKWLKACDAIPWRRPIASLNYLLTSHVWRQDHNGFSHQDPGFIDHVVNKKASVVRVYLPPDANCLLSVADHCLRSRNYVNLIVAGKQPEWQWLDIDAAVRHCTAGAGIWHWASNDDGDPDVVMACAGDVPTVETLAAVMLLREYVPDIRIRVVNVVDLMVLQPSSEHPHGLDDRRFDELFTVDKPVVFAFHGYPWLIHRLTYRRRNHFNIHVRGYKEEGSTTTPFDMVVLNDLDRYRLALDAIRRIPRLAGQVESATDRYWATMQRHKLYIGEHGDDMPEIRDWRWQA
What are the official names of this protein?
Probable phosphoketolase.
What is the protein family that this protein belongs to?
Belongs to the XFP family.
Protein: COX3_DICCI
Sequence: MKRFFENLFSQTERSVLNTGKKVGAGIAAGEWKNTEWGYPIATQEVIFLAKVFQPQHVKRHPYHIVRGTIAPLAVTLPLAFFVLNYFGVISSKIGFVIALSSFIGGLTIWAISIVFDSLYDQQHTYEVKRGLVMGMMMFIISEIMFFFSFFWSYFYISLSPNIAIGCVWPPYGLTVYSYMGLPLLNTVLLLLSGAILTDGYTILTEQKAVHENNEKVIAVEEAFTNLMNLYTKKQSINTLTFVDERREKFFAKNDQNAEKKEIAISAGVKELRDLDWDLYFFENPQNMEPNYKAPTDLSVIEYALITIFLKKRNKVIKTRLYFTLVCAVVFLFCQGYEYYFAPFSMNDGIYGSLFFLLTGFHGFHVLVGSILIGIITIRFIVGNFDLLNVGTKFQIFKNKSTGFACTLFYWHFVDIVWIFLYIVIYWWGSR
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SELO_MYCPA
Sequence: MSVAPETTVALQDRFFRELPELAVRWQAETFPELRLLVLNEPLATQLGLDTGWLRGPDGLRFLTGNLVPTGAAPVAQAYSGHQFGGFVPRLGDGRALLLGELVDNKGRLRDIHLKGSGATPFARGGDGLAAVGPMLREYVVSEAMHALGVPTTRSLAVVGTGRPVYREATLPGAVLARVASSHLRVGSFQYAAATGNRDLLRRLADHAIARHHPGAADAEQPYLALFEAVVAAQASLIAQWMLIGFVHGVMNTDNMTISGETIDYGPCAFMEAYDPDTVFSSIDFWGRYAYGNQPVIAGWNLARFAETLLPLFSENTEEAIALAERSFGVFQTRYDAVWATGMRAKLGLPAQVDAEFAAALIDELLALLKANHVDYTSFFRQLGRAARGDDRSAAEPAREMFMDLPGFDAWLARWRALGPDADAMDRVNPIYIPRNHLVEEALAAATDGDLDPLDQLLAAVTAPYTERPGFERYASPAPEDFGKYQTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: HRPX_PLALO
Sequence: MFTSLKKVATFSFLVWISQYSGSNSCSSSLVKHIPQTGSNLTFDRVLVEDTVHPEHLHEEHHHHHPEEHHEPHHEEHHHHHPEEHHEPHHEEHHHHHPHPHHHHHHHPPHHHHHLGHHHHHHHAAHHHHHEEHHHHHHAAHHHHHEEHHHHHHAAHHHPWFHHHHLGYHHHHAPHHHHHHHHAPHHHHHHHHAPHHHHHHHHAPHHHHHHHHAPHHHHHHHHGHHHHHHHHHGHHHHHHHHHGHHHHHHHHHDAHHHHHHHHDAHHHHHHHHDAHHHHHHHHDAHHHHHHHHDAHHHHHHHHDAHHHHHHHDAHHHHHHHHDAHHHHHHHHDAHHHHHHHHDAHHHHHHHH
What are the official names of this protein?
Histidine-rich glycoprotein.
Protein: PDRP_BACC4
Sequence: MDNKIVYVVSDSVGETADLVVRAAMGQFPFAPDIRRVPYVEDTGTLKEVISIAKSNQALICFTLVKPDMRQYLVTEAAKEGVEAYDIIGPLIDQIEEITGQVPRYEPGVVRRLDEEYFKKIEAIEFAVKYDDGRDARGILKADIVLIGVSRTSKTPLSQYLAHNKRLKVANVPLVPEVDPPEELYQVAKEKCFGLKITPDKLNHIRKERLKSLGLSDGATYANINRIQEEIDHFEEVISKINCQVIDVSNKAIEETANIIVNAVQNQKMF
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: EPHB1_MOUSE
Sequence: MALDCLLLFLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPSEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAAYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGVTLAGHQKKILSSIHSMRVQMNQSPSVMA
What is the function of this protein?
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3.  During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline.  This probably requires repulsive interaction with EFNB2.  In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors.  In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation.  May also regulate angiogenesis.  More generally, may play a role in targeted cell migration and adhesion.  Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.  Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (PubMed:27446912).
What are the official names of this protein?
Ephrin type-B receptor 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, dendrite.
Protein: COAD_RHIL3
Sequence: MTTAFYPGSFDPITNGHVDVLVQALNVAEKVIVAIGIHPGKAPLFSFEERAELIRRSLAEALPGKTGDISVVAFDNLVVDAARTHGATLLIRGLRDGTDLDYEMQMAGMNRTMAPDIQTIFLPAGTASRPITATLVRQIAAMGGDVSAFVPAAVLQALTSKRPN
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSRP_BORBR
Sequence: MTSTPIERAVYIVSDSTGITAETFSHSVLSQFDEVNFKPVRLPFIDTLDKAREVVARINRNALEAGVPPIVFSTLVNPEILALVRQSNGVFLDLFGTFVSHIEQALGLKSSHSIGRSHMAANSEKYRNRIDAINFSLAHDDGQFVNQLDQADVILVGVSRCGKTPTSLYLAMQYAVKAANFPLTPDDFERGALPKTIAPYRGKLFGLSIQPERLAEVRNERRPNSHYARLEQCRYEVAEAERMMRREGISWLSTTTKSIEEIATTVLQEVGLERV
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: TMM18_XENTR
Sequence: MAEDPGLWTLLERAPIDWKEPWLIGLAVFHILCLIVTYVSFKSYPLQICHFLLMVVLVSCAEYINEFAAMHWRSYSKQQYFDSSGMFISLAFSAPLLCNTIIIVVHWVYKTLCVMTELKTLQQKRKESREKRKKKE
What are the official names of this protein?
Transmembrane protein 18.
What is the protein family that this protein belongs to?
Belongs to the TMEM18 family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein.
Protein: MGRN1_MOUSE
Sequence: MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKEDADSPTEDGEKPRVLYSLEFTFDADARVAITIYCQAVEELVNGVAVYSCKNPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHVDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSSECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPISFSPVLAQSVDHDEHSSSDSIPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAGLDRIMESGLQKGKTQSKSPDSTLRSPSFPIHEEDEEKLSEDSDAPLPPSGVELVLRESSSPESFGTEEGDEPSLKQGSRVPSIDDVLQDGSPQHHGCSQPVPPADIYLPALGPESCSVGIEE
What is the function of this protein?
E3 ubiquitin-protein ligase.  Mediates TSG101 monoubiquitination at multiple sites.  Plays a role in the regulation of endosome-to-lysosome trafficking.  Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production.  Does not inhibit ADRB2-signaling.  Does not promote MC1R ubiquitination (By similarity).  Acts also as a negative regulator of hedgehog signaling (PubMed:29290584).
What are the official names of this protein?
E3 ubiquitin-protein ligase MGRN1, Mahogunin RING finger protein 1, RING-type E3 ubiquitin transferase MGRN1.
What are the subcellular locations of this protein?
Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Cell membrane. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. Nucleus. Note=In the cytoplasm, predominantly localized to the perinuclear region and discrete vesicular structures. In the nucleus, broadly distributed, but excluded from nucleoli.
Protein: NK2R_BOVIN
Sequence: MGACVVMTDINISSGLDSNATGITAFSMPGWQLALWTAAYLALVLVAVMGNATVIWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPGTRAVIAGIWLVALALAFPQCFYSTITTDEGATKCVVAWPEDSGGKMLLLYHLIVIALIYFLPLVVMFVAYSVIGLTLWRRSVPGHQAHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGTFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDKMELTYTPSLSTRVNRCHTKEIFFMSGDVAPSEAVNGQAESPQAGVSTEP
What is the function of this protein?
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A).  It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.  The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
What are the official names of this protein?
Substance-K receptor, SKR, NK-2 receptor, NK-2R, Neurokinin A receptor, Tachykinin receptor 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RAB18_BOVIN
Sequence: MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLTHREEGQGGGACGGYCSVL
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity).  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity).  Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity).  Also required for maintaining endoplasmic reticulum structure (By similarity).  Plays a role in apical endocytosis/recycling (By similarity).  Plays a key role in eye and brain development and neurodegeneration (By similarity).
What are the official names of this protein?
Ras-related protein Rab-18.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Apical cell membrane. Lipid droplet.
Protein: HCP_SALEP
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINHDVDNFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLSVDANAHCDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECAMEIGQMNFKVMSILDAGETTKYGHPTPTQVNVKATEGKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGSYDDRIWTRSIVGWPGVSHLEGDDFGPVIAQAQQMAGFPYSEIPHLITVGFGRQTLLGAADTLIDLVSREKLRHIFLVGGCDGARGERNYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFFTPDLLAVLNEKFGLRSVTTVEEDMKQLLSA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADCY9_HUMAN
Sequence: MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAIEKDDCDETGIEEANELTKLNVSKSV
What is the function of this protein?
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815).  Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).
What are the official names of this protein?
Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, ACIX, Adenylyl cyclase 9, AC9.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACSA_ECO57
Sequence: MSQIHKHTIPANIADRCLINPQQYEAMYQQSINAPDTFWGEQGKILDWIKPYQKVKNTSFAPGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDASQSKHISYKELHRDVCRFANTLLKLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSNSRLVITSDEGVRAGRSIPLKKNVDDALKNPNVTSVEHVVVLKRTGGKIDWQEGRDLWWHDQVEQASDQHQAEEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMAQVVDKHQVNILYTAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGNEKCPVVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNEGNPLEGATEGSLVITDSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARRDEDSYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHNIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLEEKQAIAMPS
What is the function of this protein?
Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt.  Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: DNAA_OLEA2
Sequence: MINAWAQIEHTLRDNLNPGLFKVWIKPLAAEQAGDSLRLVAPNAFVASWVRDRLMNEIEKAAASVLGSVPTITVVSGEEPAAAPRPVQVPAQKRPAAARTSGAEQMGLPLHYASRSADSIKWMHSFDEFVVGPSNQMAFAASQDICQQSFRSDTLFLSSDPGLGKTHLLHAVGQQLCNISNRTLPRVEYLTAEEFATRLICALKAKEVDRFKARYRDVDVLLLEDVHFLQGKQRMQDEVLSTVKALQSRGAKVLFSSSFAPKDLNDLDSQLTSRFCSGLLAVIEKPTFETRKQILREKARLHHVQLPEQVADLLADNIRADVRQIESCLRNLLLKARLLNQQITMDMAWEIIGHYAKREAVLDIDAIVRQICSGFDISKEQLQSRSRRRELVIARNTAFFLARKHTDLSLEEIGKRFNRKHSTVIKGIANIEREMNKETPLGRQVVNAVNMVERNGRIIHP
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.