PharMolix/UniProtQA huggingface dataset:
Protein: SPGX_DICDI
Sequence: MNIRNTLVLLVSTVLVLMSCSIGCYAGSPNCVGAPSGQVYIFSSWDFQGDRYVYNISQGQTTLPDSFIHNVQSFTSGSEICFASCNPLETYQISAGQSHRNYAALENFGQRMNLIIPGNCSNLVCPSN
What are the official names of this protein?
Spore germination protein 1/2/3-related protein.
What is the protein family that this protein belongs to?
Belongs to the Dictyostelium gerABC family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y4342_METAC
Sequence: MPIILENVSFFYSKNTPLETAALKDVNLRIEKGEFVGILGEKGAGKSTLIKLFNGLLRPESGKVTVDGLSPFSKEVKRKVGMLFQQAADQLFCRTVHEEIAFGPRNFGYSKKETEERVFEALEAVSFDRSMLLRDPFSLSGGEMQRVALAGALALRPDYLVLDEPITGLDPAGKKEILETLKKIKDQGTAVITVTHNLKGFFPLLEKIVLVREGRISFQGSREEYLEAKNVPLPPVTSMMRELKARGLPVNPAIFTVEEALEEILRVKSRLEKEKTEKWSETD
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein MA_4342.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LEUC_BUCPS
Sequence: MGKTLYHKLYNSHIVYEQNNVTSILYIDLHLIHEVTXPQAFNSLRLKNRKIRQPKKTFATMDHNVPTHNRDIKNSEYMAKIQMEELSKNCKDFNIKLYDINHPHQGIVHVLGPEKGMTLPGMVIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLQQNRLKTMNIEITGNINPMVFAKDIILSIIRKLSTSGGIGYVIEFSGSVISQLSMESRMTICNMSIEMGAKSGLIAPDIITYNYLKNKSYSPKNKYWNNAINYWNTLKSDKNAFFDKKISINISNLAPQITWGTKPDQVISIDEPIPNIDSLKMFLNKNQLKNPLLYMGLKPGEYLNNLVVDKVFIGSCTNSRTEDLRAAANIVQNTHVAKNVHAIVVPGSGMVKLQAEEEGLDKIFINAGFEWRLPGCSMCLGMNLDRLKPKERCASTSNRNFEGRQGRDGRTHLVSPAMAAAAAIFGHFVDIRKI
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: H2B2F_HUMAN
Sequence: MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B type 2-F, H2B-clustered histone 18.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: KA191_MESMA
Sequence: AACYSSDCRVKCVAMGFSSGKCINSKCKCYK
What is the function of this protein?
Selective inhibitor of high conductance calcium-activated potassium channels KCa1. 1/KCNMA1.  May be insect specific.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 19.1, BmK37, Neurotoxin BmBKTx1.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 19 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAG_SACS2
Sequence: MSFQMKYDIRLRFEVEGIVEKTDVIGAIFGQTENLFGDEFDLRELQDKGRLGRIIVEVKTKGGKSEGEIIIPSNLDRIETALIAAMVESVDKVGPYNSKFELIEIEDIRAEKLKKIIERAKGILSSWSKEKSLDIKEVINEISSAVKVGEITEYGPERLPAGPDVDKDPNLIIVEGRADVINLLRYGYKNVIAVEGATSRIPETLINLSKMKKTVIAFLDGDHGGDLILKELLSNNVKIDFVARAPIGREVEELTGKEIAKALSNMMPLTQYLKKVQEAEQAIAKNVIAKEEKPIQSETTQQVVQITLPQNILEEIKKLPGTLEGVLYDNNWNLIEKVQVRDIIPKLEAYEDNKVAYIIFDGVITQRLLDLASQKNIKMIIGARIGGINKRPQNVDILTFTDIISS
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Can use NTPs but not dNTPs.  Binds DNA.  Also part of the exosome, which is a complex involved in RNA degradation.  Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: PCBP3_MOUSE
Sequence: MGEGDAIWAPPILPHSTLGTLSHHPELHFGGKMESKVSEGGLNVTLTIRLLMHGKEVGSIIGKKGETVKKMREESGARINISEGNCPERIVTITGPTDAIFKAFAMIAYKFEEDIINSMSNSPATSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVTISGTPDAIIQCVKQICVVMLESPPKGATIPYRPKPASTPVIFAGGQAYTIQGQYAIPHPDQLTKLHQLAMQQTPFPPLGQTNPAFPGEKLPLHSSEEAQNLMGQSSGLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIANATEGSSERQITITGTPANISLAQYLINARLTSEVTGMGAL
What is the function of this protein?
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
What are the official names of this protein?
Poly(rC)-binding protein 3, Alpha-CP3.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETR1_MALDO
Sequence: MLACNCIEPQWPADELLMKYQYISDFFIALAYFSIPLELIYFVKKSAVFPYRWVLVQFGAFIVLCGATHLINLWTFSIHSRTVAMVMTTAKVLTAVVSCATALMLVHIIPDLLSVKTRELFLKNKAAELDREMGLIRTQEETGRHVRMLTHEIRSTLDRHTILKTTLVELGRTLALEECALWMPTRTGLELQLSYTLRQQNPVGYTVPIHLPVINQVFSSNRAVKISANSPVAKLRQLAGRHIPGEVVAVRVPLLHLSNFQINDWPELSTKRYALMVLMLPSDSARQWHVHELELVEVVADQVAVALSHAAILEESMRARDLLMEQNIALDLARREAETAIRARNDFLAVMNHEMRTPMHAIIALSSLLQETELTAEQRLMVETILRSSNLLATLINDVLDLSRLEDGSLQLEIATFNLHSVFREVHNMIKPVASIKRLSVTLNIAADLPMYAIGDEKRLMQTILNVVGNAVKFSKEGSISITAFVAKSESLRDFRAPDFFPVQSDNHFYLRVQVKDSGSGINPQDIPKLFTKFAQTQALATRNSGGSGLGLAICKRFVNLMEGHIWIESEGLGKGCTATFIVKLGFPERSNESKLPFAPKLQANHVQTNFPGLKVLVMDDNGVSRSVTKGLLAHLGCDVTAVSLIDELLHVISQEHKVVFMDVSMPGIDGYELAVRIHEKFTKRHERPVLVALTGSIDKITKENCMRVGVDGVILKPVSVDKMRSVLSELLEHRVLFEAM
What is the function of this protein?
May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.
What are the official names of this protein?
Ethylene receptor.
What is the protein family that this protein belongs to?
Belongs to the ethylene receptor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GLYA_CORU7
Sequence: MSDSPQTIQHNVPLAELDPDVARAIDGELARQRNTLEMIASENFVPRAVLQAQGSVLTNKYAEGYPGRRYYGGCEHVDVIEDLARDRAKQVFGAEFANVQPHAGAQANAAVLMALASPRDKILGLSLAHGGHLTHGMHLNFSGKLYEAIAYEVDPETMRIDMDKVREQALKEKPTVIIAGWSAYPRHQDFAAFRSIADEVGAKLWVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGPRSGLILAKQEWAKKLNSAVFPGQQGGPLMHAVAAKAVAMKVAQTEEFRDRQARTLEGAKILAERLSAADTKGAGVEVLTGGTDVHLVLADLRHSELDGQQAEDLLHEVGITVNRNAVPFDPRPPMVTSGLRIGTPALASRGLDTAAFTEVADVIGTALAQGKNADVEALRARVSKVAEDFPLYEGLEDWKLV
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINE_CHLSY
Sequence: MSFLNGLFGRKRDSSAELAKQRLLTVLIDDRYKLTPEMMAQMKADLAEVLKRYLPAIDAEQIEVTLSRGEAHDLLKADVPLRRATDHPPNR
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: Y2433_MYCLE
Sequence: MTGPHNDTESPHARPISVAELLARNGTIGAPAVSRRRRRRTDSDAVTVAELTCDIPIIHDDHADEQHLAATHAHRANIGVRVVEPAAQSPLEPVCEGIVAEPPVDDHGHVPPGCWSAPEPRWPKSPPLTHLRTGLQRSACSRPLPHLGDVRHPVAPDSIAQKQSDAEGMSPDPVEPFADIPVDVMGSEVRAAELVAEESAYARYNLQMSAGALFSGHTLTNELAERRGDEHAAGGLLAVGIDLDEDHLDLHTDLAGITSPARGWQSRFEALWRGSLIVLQSILAVVFGAGLFVAFDQLWRWNSIVALVLSVLVILGLVVGVRVVRRTEDIASTLIAVVVGALITLGPLALSLQSG
What are the official names of this protein?
Uncharacterized protein ML2433.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv0497.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TDH_DEIDV
Sequence: MKALSKQESRAGIWMVDTEVPRPGPNDLLIRVKKGSICGTDVHIYKWDEWAQKTIPVPMVVGHEYVGVVAAMGSEVRGFNVGDRVSGEGHVTCGHCRNCRAGRRHLCRNTLGVGVNRPGSFAEYLVLPAFNAFKLPDDIPDDVAAIFDPFGNAVHTALSFDLVGEDVLVTGAGPIGVMAAAVARHVGARNVVITDINDYRLDLARKMGVTRAVNVTKEDLWSVARNELGMTEGFDVGLEMSGSGPAFAQMVDVMNNGGKIALLGIPSGDVRIDWNAVIFKMLTIKGIYGREMFETWYKMAALIQSGLDLRPIITHHFGIDDFQQGFDAMLSGQSGKVILDWEKR
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_PEDPA
Sequence: MEENNQAFHSGFVAIVGRPNVGKSTFLNYVIGQKVAIMSNVPQTTRNKIQGIYTTDREQIVFIDTPGIHKSHNKLGDFMVQSAMSSLNEVDAIMFMVNADEPRGAGDNYIIERLKKITDRPVYLVINKIDLVHPDELLPIVDSYKDAMDWTEVFPISALQGNNINELVTTLSQHMPEGPKYYPDDQVTDHPERFVVSELIREKVLQLTRQEVPHSVAVVIETMKSNDEGLVNIQATIIVDRSSQKGIVIGKGGKMLKEIGSRARVDIEHLLGSRVYLELWVKVSEGWRDKQGILQSFGYKKDEY
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: RBFA_RICAE
Sequence: MKKLTKTHSHRQQKLASIINEALIEILRRGKMLDTRLFDCPLTITKVIVTADLKIANCYFLPFNTKLTIDEIMDALNNSKNAIRNFITNKINMKFSPDIRFYYDHGFDNAIKVAHLLKDL
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTSB_SALTS
Sequence: MAEPLTVSPELTANYAYFFDLDGTLAEIKPHPDQVVVPHKILQLLDRLAAHNAGALALISGRSMTELDALAKPFRFPLAGVHGAERRDINGKTHIVRLPEAVVREVEALLRSTLVALPGTELESKGMAFALHYRQAPEHEAALLALAQHVTQHWPQLALQLGKCVVEIKPKGTNKGEAIAAFMQEAPFAGRIPVFVGDDLTDEAGFGVVNHAGGISVKVGVGATQAAWRLESVPDVWRWLEQINYPQQEQQVMNNRRDGYESFSRSI
What is the function of this protein?
Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
What are the official names of this protein?
Trehalose-phosphate phosphatase, TPP, Trehalose 6-phosphate phosphatase, Trehalose-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the trehalose phosphatase family.
Protein: YIDD_LIMRD
Sequence: MVRILCDLIRWYQQGISAQRPFRVCRFTPSCSQYMLEALQRFGLKGILLGSWRLLRCQPFSRGGYDPVPNHFTFRRQG
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: S14L5_HUMAN
Sequence: MVQRYQSPVRVYKYPFELVMAAYEKRFPTCPQIPVFLGSEVLRESRSPDGAVHVVERSCRLRVDAPRLLRKIAGVEHVVFVQTNILNWKERTLLIEAHNETFANRVVVNEHCSYTVHPENEDWTCFEQSASLDIRSFFGFENALEKIAMKQYTANVKRGKEVIEHYLNELISQGTSHIPRWTPAPVREEDARNQAGPRDPSSLEAHGPRSTLGPALEAVSMDGDKLDADYIERCLGHLTPMQESCLIQLRHWLQETHKGKIPKDEHILRFLRAHDFHLDKAREMLRQSLSWRKQHQVDLLLQTWQPPALLEEFYAGGWHYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSVNEEGQKRCEGSTRQLGRPISSWTCLLDLEGLNMRHLWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRRKFLIYSGSNYQGPGGLVDYLDREVIPDFLGGESVCNVPEGGLVPKSLYMTEEEQEHTDQLWQWSETYHSASVLRGAPHEVAVEILEGESVITWDFDILRGDVVFSLYHTKQAPRLGAREPGTRASGQLIDKGWVLGRDYSRVEAPLVCREGESIQGSHVTRWPGVYLLQWQMHSPPSSVACSLPGVDDVLTALHSPGPKCKLLYYCEVLASEDFRGSMSSLESCTSGFSQLSAATSSSSSGQSHSSSLVSR
What are the official names of this protein?
SEC14-like protein 5.
Protein: GHRL_RAT
Sequence: MVSSATICSLLLLSMLWMDMAMAGSSFLSPEHQKAQQRKESKKPPAKLQPRALEGWLHPEDRGQAEEAEEELEIRFNAPFDVGIKLSGAQYQQHGRALGKFLQDILWEEVKEAPANK
What is the function of this protein?
Obestatin may be the ligand for GPR39.  May have an appetite-reducing effect resulting in decreased food intake.  May reduce gastric emptying activity and jejunal motility.
What are the official names of this protein?
Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide.
What is the protein family that this protein belongs to?
Belongs to the motilin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL23A_TRYBB
Sequence: MPAKAASAAASKKNSAPKSAVSKKVAKKGAPAAAAKPTKVVKVTKRKAYTRPQFRRPHTYRRPATVKPSSNVSAIKNKWDAFRIIRYPLTTDKAMKKIEENNTLTFIVDSRANKTEIKKAIRKLYQVKTVKVNTLIRPDGLKKAYIRLSASYDALDTANKMGLV
What is the function of this protein?
This protein binds to a specific region on the 26S rRNA.
What are the official names of this protein?
60S ribosomal protein L23a, L25.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RPE_MYCTO
Sequence: MAGSTGGPLIAPSILAADFARLADEAAAVNGADWLHVDVMDGHFVPNLTIGLPVVESLLAVTDIPMDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPVGVARDIRAAGAKAGISVKPGTPLEPYLDILPHFDTLLVMSVEPGFGGQRFIPEVLSKVRAVRKMVDAGELTILVEIDGGINDDTIEQAAEAGVDCFVAGSAVYGADDPAAAVAALRRQAGAASLHLSL
What is the function of this protein?
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
What are the official names of this protein?
Ribulose-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the ribulose-phosphate 3-epimerase family.
Protein: F16PC_STAAW
Sequence: MTQITEKELKKKYLDLLSQNFDTPEKLATEIINLESILELPKGTEHFVSDLHGEYEAFQHVLRNGSGNVRAKINDIFKERLSTKELNDLTALVYYPEDKLKLIKSDFQSCGQLNVWYITTIEHLIELIKYCSSKYTRSKLRKALPKQYVYIIEELLYKSNEYQNKKSYYETLVNQVIELKQADDLIIGLAYSVQRLVVDHLHVVGDIYDRGPQPDKIMDTLINYHSLDIQWGNHDVLWVGAYAGSKVCLANLLRICARYDNLDIIEDAYGINLRPLLTLAEKYYDADNPAFKPKKRPDKHERLTQREESQITKIHQAIAMIQFKLEIPIIKRRPNFEMEERLVLEKVNYDTNEITVYGNTYPLKDTCFQTVNRDNPAELLPEEEEVMNKLLLSFQQSEKLRRHMSFLMRKGSLYLPYNGNLLIHGCIPVDENGEMESFEIDGHTYSGQELLDVFEYHVRKSFDEKENTDDLSTDLVWYLWTGKYSSLFGKRAMTTFERYFIADKASHKEEKNPYYHLREDVNMVRKMLSDFGLNADEGRIINGHTPVKEINGEDPIKADGKMLVIDGGFSKAYQSTTGIAGYTLLYNSFGMQLVAHQQFNAKEKILSEGIDELSIKRVVDKELQRKKIRDTNIGKDLQAQIDILKMLMHDRYLD
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 3, FBPase class 3, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 3 family.
Protein: MURI_SHESM
Sequence: MSQPILVFDSGIGGLSVLAEIRKLLPHHDYCYLFDNARLPYGELEEQELVSGCVALIDQVVERTHAAIVVVACNTASTVVLPALRATLSIPVVGVVPAIKPAAQLSKSKRIGLLATPGTVKRHYTYELISQFADDCHVELFGSSELVLMAEQKIATGQLDMARLTQVLSPIVTADLDVLVLGCTHFPMLRDELQQVLGKGVTLLDSGEAIAKRVKTLLAETKSEQQVQEDANRDSVMQAFYTKAKISEGLVSMLVDCGFSTLERITTINSNR
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: RS10_LACJO
Sequence: MASQQIRIRLKSYEHGILDESAAKIVATAERTGAQISGPVPLPTERTLFTVLRSPHKNKDSREQFEIRTHKRLIDILNPTPKTVDSLMKLDLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: SYGB_YERPP
Sequence: MTQQTFLVEIGTEELPPKALRSLAESFAANFTAELDNANLSHGEVSWYAAPRRLAVKVANLSAAQADREVEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLVTDKGEWLLYRAHVKGQPAQLLLAGMVNTALSKLPIPKLMRWGDKETQFVRPVHTVTLLLGTEVIPGTVLGINSDRVIRGHRFMGEAEFTIDSADQYPQILLERGKVIADYELRKSIIKRDAEQAAQQIGGVADLSESLLEEVASLVEWPVVLTAKFEEKFLAVPAEALVYTMKGDQKYFPVYDTAGHLMPHFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFKTDRKKRLEDNLPRLETVLFQQQLGTLRDKTDRIQALAGWVAAQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLSLDLQTLTEEAVRLYGSKLTNAKVVDDVIEFMLGRFRAWYQDEGHSVDTIQAVLARRPTKPADFDARVKAVTYFRTLDAAAALAAANKRVSNILAKSTDTLNDHVHASILKEPAELKLATHLVVLRDQLEPVFAAGQYKEALVELAALRETVDEFFESVMVMAEDDAVRVNRLTLLSKLRELFLQVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WHIA_LEIXX
Sequence: MALTADVKDELTKVEVSKTTVRAAELATILRFSGGLHLIGGRIAVESELDTPELARRVRKDLAELYGVRGVVSVISTSGVRRASQYLVRVLDGGETLARQTGLLDAHRRPIRGLPNRLTTGSREELAAVWRGAFLASGSLTDPGRSAALEVTCPGNEAAMALVGAAGRIGVAAKAREVRGVHRVVIRDGEAISAMLVQMGAAQTVSNWEELRQRREVRATANRLVNFDDANLRRSAQAAVAACARVERALEILGDDIPEHLQYAGRLRLAHRDASLDELGHYADPPMTKDAVAGRIRRLLAMADKRASDLGVPSTEASLPADFDEV
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: PLK4_BOVIN
Sequence: MATCIGEKIEDFRVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRRKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLAAQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSKKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDRRRLLIEQPLPNKMTIFPKNKNPSDFSSSGDGISFYTSWGNQEQETSNSGRGRVIQEAEERPHSRYLRRAHSSDRSETSHGQSRVKTYTMERCYSAEMLSKSKRSGVEENERYSPTNNDANIFHFFKEKTSNSSGSFEGPDNNQALSNHLCPGKTPFPFPEQTPQTEMVQQWFGNLQINDPSCEQSKTRGVEPPLVYQKRTLRSITSPLTAYRLKPIRQKTKKAVVSILDSEEVCVELLKDYASQEYVKEVLQISSDGSMITIYYPNDGRGFLLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCVLMENSPGADFEVWFYDGAKIHKTEDLIQVIEKTGRSYTLKGESEVNSLKEEVKMYMNHANEGHRICLALESIISEEEKKSGSAPFFPIIVGRRPSSTSSPKALTPPPPVDPNYPMRETPSLNRMIINSAASPKQAPVLNPPVVTNEGLGLMGAASETNSSPRSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILLMFSNPTPSFH
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.  Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6.  Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors.  Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles.  Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1.  Phosphorylates CDC25C and CHEK2.  Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity).  Phosphorylates CEP131 and PCM1 which is essential for proper organization and integrity of centriolar satellites (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase Sak.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrioles throughout the cell cycle. Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity).
Protein: CYOE1_SHEWM
Sequence: MAKPLSISSSDTQSQPLQWRAYYEMTKPKVVALMLLTVLVGMCLALPGAVPLQPLIFGLLGIGMMAGAAAAFNHLIDRRIDGLMARTYNRPLPKGRVSITKALTFSISLAVLGFVLLYTLVNELTAWLTFASLLGYAVVYTAYLKRATPQNIVVGGLAGAMPPLLGWTSVTGEFHGNALLLVIIIFAWTPPHFWALAIHRKAEYAKVDIPMLPVTHGTEFTKTCILLYTILLAIACLLPVLVGMCGPLYLVGSTLLSCGFIYKSWELKFDDKPGLAMQVFRFSIYHLMLLFIVLLVDHYLWV
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase 1, Heme B farnesyltransferase 1, Heme O synthase 1.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAD_HALMA
Sequence: MSNPRILIVGPPGAGKGTQSANLAEAYGVEHITTGDALRANKDMDISDMDTEYDTPREYMEAGDLVPDAVVNAIVDEALSQADGFVLDGYPRNLEQAEELEGMTALDVILSLDVSREELVDRLTGRRVCDDCGTNYHVEFNQPEEDGVCDECGGDLIQRDDDNEESVRNRLDVFDDNTAPVIDHYGDHDGFVAIDGEQTPDEVWSEIQDAVDAHTA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.