PharMolix/UniProtQA huggingface dataset:
Protein: LDHB_CHICK
Sequence: MATLKEKLITPVAAGSTVPSNKITVVGVGQVGMACAISILGKGLCDELALVDVLEDKLKGEMMDLQHGSLFLQTHKIVADKDYAVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPNCTILVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDTARFRYLMAERLGIHPTSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPAMGTDKDSENWKEVHKQVVESAYEVIRLKGYTNWAIGLSVAELCETMLKNLYRVHSVSTLVKGTYGIENDVFLSLPCVLSASGLTSVINQKLKDDEVAQLKKSADTLWSIQKDLKDL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase B chain, LDH-B.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNT5_DANRE
Sequence: MDEKYSSNVISSGKLGRVEAPNARLTRYIVLLYFTKMLKAFGIFESYDILKVVHIVQFLFILKMGCAVILVFFQKPFSSGKMIPKRQWIKILKHAVISCIISLLGFFGLTLCGPLRSLLLFEHSDLVVISLLSVLFTSSGGGPSKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHALYTGIAFLGVADHKGGVVLLVLALCLKVAFNTASRKLSVEIGGAKRLYALSNLVSAVVLLPWVIVLSATTESKVESWSGLIFPFAMIIFSVMILDFYVESICMAKLETSRCARYGAIFLFLNGLLLANFWTHPLTGQIRAISTTGQQSSTEHVLSGGVLVSACFFIMADSILSAPSSKGQKGTLVGYSPEGTPLYNFMGDALQHTSQSLPRFIKDSLKQILEEYDSRQIFYFLCLNLAFTFVELFYGVWTNSLGLISDGFHMLFDCSALVLGLFAALMTRWKATRIYSYGYGRVEILSGFINGLFLMVIAFFVFVESVTRLVDPPNINTDMLTPVSVGGLIVNLVGICAFSHAHSHGASKGSCSGHDHGHSHHGHGHSSMEHSHGGHGHSHGGHGHSHGHGHSHSSGGMNANMRGVFLHVLADTLGSVGVIISTILIRQFGWLIADPICSLFISTLIFLSVIPLLKDACEVLLLRMPPQHEKELNFALEKIQKIEGVLSYRDPHFWRHSASVIAGTIHLQLMSDVVEQRVIQQVSAVLKDAGVNNLTIQLEKEAYFQHMSGLSSGFHEVLTMTQQMESMKYYKDGTCIM
What is the function of this protein?
Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway.  By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
What are the official names of this protein?
Proton-coupled zinc antiporter SLC30A5, Solute carrier family 30 member 5, Zinc transporter 5, ZnT-5.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Protein: PVK1_DIPPU
Sequence: GSSGLIPFGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, DipPu-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARXH_CAEEL
Sequence: MPELKKEDSSKDEKDLDMNCPPLHRPNGADLNQYSKSLMEQLQAQLFANPALQFPSFPPAFSIAALTNNQHELKEDDGKKTPTGDNILEAASVLDNRENGSPSDGTNSPDDNGKRKQRRYRTTFSAFQLDELEKVFARTHYPDVFTREELATRVQLTEARVQVWFQNRRAKYRKQERSSTHHPYQAPMSIPNSNGDNPYQMMLSQEAIFAAINQQAAAHLLNEQVRIATSDRRSQSPSVPVTTSSPILPTSVTPTFQNADALNMLFGGITPVTQQLLYVQQFSRAMDAFRTQLLGSVPAGATAEVTDVVALKTEDSKSNSRAGSSSPTPTESSGAAATSTSPTNFADMNSLISDVKPKEESS
What is the function of this protein?
Transcription factor (By similarity).  Involved in activating or repressing transcription of genes in neurons (PubMed:15790968, PubMed:21368126).  Regulates expression of nuclear hormone receptor odr-7 and LIM homeodomain protein lin-11 in AWA and ASG chemosensory neurons (PubMed:15790968, PubMed:21368126).  In concert with lin-11 and forkhead domain protein unc-130 plays a role in specifying AWA and ASG cell fates (PubMed:15790968).  Plays a role in modulating dendritic morphology and functions of AWA neurons (PubMed:15790968).  Involved in regulating GABAergic motor neuron development, acting in parallel with nuclear hormone receptor unc-55 (PubMed:15790968, PubMed:31691806).  Required to maintain the functional and structural integrity of the amphid organs during larval development (PubMed:16055504).  Plays a role in anterior hypodermal morphogenesis (PubMed:16055504).  Required for touch sensation (PubMed:21368126, PubMed:31691806).  May act as a transcriptional activator in touch receptor neurons (TRNs), forming a positive feedback loop with transcription factor mec-3, thereby restricting the variability of expression of target genes such as mec-3 (PubMed:21368126).  Positively modulates expression of H3K4 demethylase rbr-2 in early embryogenesis and during larval development (PubMed:31691806).
What are the official names of this protein?
Homeobox ARX homolog alr-1, Aristaless-related homeobox alr-1.
Protein: CTTB2_RABIT
Sequence: MATDGASCEPDLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGASDKEKKPVCTNPLSILEAVMAHCRKMQERMSTQLAAAESRQKKLEMEKLQLQALDQEHQKLAARLEEERGKNRHVVLMLVKECKQLSGKVIEEAQKLEEVMASLEEEKKKTNDLEEQLCTEKRRSAEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMKKMIEQLKRGSDSKPSLSLPRKTKDRRLASVSVATEGPVTRAVACQTDPVTESTDHVRKLPLTVPAKPSAGSPLVSANTKGNVCPHAAPGRPGMDRQASHGDLMGSSAPTIPAASASRMEANGPSPGSTPDLTSSTPPIPSGTTPAPAHAPGVATQSPVPAAPGHGLHSPCATTALHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQVGTPPRPGVPPTGDVATHPPVSRSGLKTPGGARVDRGNPPPIPPKKPGLSQTPSPPHPQLKIPVDSSRASSAGAKVENKTVASPPSSLPPGSRVITEENPPKSSSPQLPPKPSIELTVAPAGCAVSALAASQVGAWPAETLGLKPPACSDSSLVIPNTIAFRSSINPVSASTSRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDTNYSCEDGHSALYSAATNGHADCVRLLLNAEAQVNAAEKNGFTPLCAAAAQGHFECLELLLASDADVNHAADGGQTPLYLACKNGNTDCIKLLLEAGTDRSIKTRDGWTPVHAAVDTGNVDSLKLLMYYQAPARGNSSNEEEPESGAFARDGGEESSEGTSEPVVSADLINHADREGWTAAHIAASKGFKNCLEILCRHGGLEPEKRDKCNRTVHDVATDDCKHLLENLNALKIPLRISVGEIQPDNCGSDDFECENIICTLSIRKQTSWDDFSKAVSQALTNHFQAISSDGWWSLEDVAFNNTTDSSIGLSASSVRSITLGNMPWPAGRSFAPSPWDFVRKNKTEQVTALLSGPQEGCLSSVTYASMIPLKTLQNYLRLVEQYHNVIFHGPEGSLQDFIAHQLALCMKHRQMAAGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSPVKKKIIIILENLENSSLSELLGDFLAPLENRSTESPCTFQKGNGASECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGLLPRFLRRKVVNKFRGQVPAPCDPVHKTVAWALSVWRQLNSCLAHLGTPEALLGPKYFLSCPVVPGRAQATVKWMSKLWNAVIAPRVQAAILSRASVKRQPGLGQTAAKKHPSHGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFRGGSFPLSIVSSYNSCSKKKGESGAWRKVSTSPRKKSGRFSSPIWNEPDLSPGGIKNKAISQLNCGRNTSLSKQKSLENELSLTLNLDQRFSLGSDDAADLVKELQSMCSSKSESDLSKIADSREELRTFHSSGSNPAFSAPVNNPRMPVAPKEVSPLSSHQATECSTSKSKTELGVSRVKSFLPVPRSKIAQCSQNTKRSSSSSNTRQPEINNNSKEENWNLHKHEQVEKPNT
What is the function of this protein?
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
What are the official names of this protein?
Cortactin-binding protein 2, CortBP2.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation.
Protein: LGT_ECO5E
Sequence: MTSSYLHFPEFDPVIFSIGPVALHWYGLMYLVGFIFAMWLATRRANRPGSGWTKNEVENLLYAGFLGVFLGGRIGYVLFYNFPQFMADPLYLFRVWDGGMSFHGGLIGVIVVMIIFARRTKRSFFQVSDFIAPLIPFGLGAGRLGNFINGELWGRVDPNFPFAMLFPGSRTEDILLLQTNPQWQSIFDTYGVLPRHPSQLYELLLEGVVLFIILNLYIRKPRPMGAVSGLFLIGYGAFRIIVEFFRQPDAQFTGAWVQYISMGQILSIPMIVAGVIMMVWAYRRSPQQHVS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MED4_RAT
Sequence: MAASSSGEKEKERMGGVSGMTGLGSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQLEEENQVLELLIHRDGDFQELMKLALNQGKVHHEMQALEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTSGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSTDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 4, Mediator complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GANA_ASPFU
Sequence: MLGKTVLLPLLVLLCHSLASASLVYRGADISSLLIEEKAGIEYKNVNGQTQPLENILKANGVNSVRQRVWVNPSDGSYNLDYNVKLAKRVKAAGMSVYLDLHFSDTWADPSHQTTPRGWSTNDIGTLTWQVYNYTMEVCNTFASNGIDVSIVAIGNEIRNGLLWPLGKPDNYANIANILHSAAFGVKDSTLSPKPKIMIHLDNGWDWSAQKFFYNRVLSSGANLVKSDFDLIGVSYYPFYNPSATLSALTTSLKNLRSTYGKDVLVVETDWPVSCPNPAYAFPSDLKDIPFSVAGQTTFVQRVANIVAQTPGGIGLYYWEPAWVQNAALGSSCADNLMVDWSTRQARTSLSVFATI
What is the function of this protein?
Endogalactanase involved in the degradation of plant cell wall polysaccharides, and more particularly of hairy regions of pectin.
What are the official names of this protein?
Probable arabinogalactan endo-beta-1,4-galactanase A, Endo-1,4-beta-galactanase A, Galactanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 53 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YVEK_BACSU
Sequence: MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTYQASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSLKGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAKASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSVPDVHKGRNRGIKHFGE
What are the official names of this protein?
Uncharacterized protein YveK.
What is the protein family that this protein belongs to?
Belongs to the CpsC/CapA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLAE_VIBCH
Sequence: MAMTVNTNVSALVAQRHLNSASEMLNQSLERLSSGNRINSAKDDAAGLQISNRLETQMRGLGIAVRNANDGISIMQTAEGAMQETTQLLQRMRDLSLQSANGSNSAAERVALQEEMAALNDELNRIAETTSFAGRKLLNGQFMKASFQIGASSGEAVQLSLRNMRSDSLEMGGFSYVAAALADKQWQVTKGKQQLNISYVNAQGENENIQIQAKEGDDIEELATYINGKTDKVSASVNEKGQLQLYIAGKETSGTLSFSGSLANELQMNLLGYEAVDNLDISSAGGAQRAVSVIDTALKYVDGHRSELGAMQNRFQHAISNLDNVHENLAASNSRIKDADYAKETTQMIKQQILQQVSTSVLAQAKRQPKFVLFLLRN
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.  FlaE is not essential for flagellar synthesis and motility.
What are the official names of this protein?
Flagellin E.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: AHNL_LINUS
Sequence: MASLPVSFAKPDKNGVITCKAIMLKEAKLPGMSYADTVQIIDIQVDPPQNVELRVKMLCASVCRTDILTIEGFMAPTQFPKINGHEGVGIIESMGPDTKNFKVGDVIVAPTLGECQVCSSCRSGRTNFCQNYGANESALEPDGTSRFSYIDSDGKKKLLYYKLGCSTWTQYMVVDSNYATKLNEIAPELPPPHGSILSCAFATGYGAVWLDAAVQEGDSVAIFGVGSVGISAVIAAKELKAKQIIVVDRNEYKLKMAMELGATHCINSEKLPEGVTPSQAVRKLTPKEVGVDASIESSGYDVFMNEAMKAAIHGKAKTVITGEGIYENDRIFFDFKDFLFGGNVVGNVTGRVRIHSDFPGLLRKAQEPVIRAGMDKILGYDAATMKCKYEVDIREGTPALLKALEEVENVDCVKLVIKLNDY
What is the function of this protein?
Involved in the catabolism of cyanogenic glycosides.  Naturally occurring substrates are the aliphatic acetone cyanohydrin and butan-2-one cyanohydrin, which are the aglycones of the cyanogenic glycosides linamarin, lotaustralin, linustatin and neolinustatin.  Can use various aliphatic ketones and aldehydes as substrates, but not aromatic ketones.
What are the official names of this protein?
Aliphatic (R)-hydroxynitrile lyase, LuHNL.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: MIAB_VIBVY
Sequence: MSKKLLIKTWGCQMNEYDSSKMADLLNAANGYELTEEPEEADVLLLNTCSIREKAQEKVFHQLGRWKTLKDKKPGVVIGVGGCVATQEGDHIRERAPFVDVIFGPQTLHRLPEMIKQSQSEDAPVMDISFPEIEKFDSLPEPRAEGATAFVSIMEGCSKYCTYCVVPYTRGEEVSRPMDDVLYEIAQLAEQGVREVNLLGQNVNAYRGPMHDGEICSFAELLRLVASIDGIDRIRFTTSHPLEFTDDIIAVYEDTPELVSFLHLPVQSGSDRILTMMKRPHTGIEYKSIIRKLRKARPDIQISSDFIVGFPGETDKDFQDTMKLIKDVDFDMSFSFIFSPRPGTPAADYPCDLSEETKKERLYELQQQINAQAMRYSRLMLGTEQRVLVEGPSKKNLMELRARTENNRVVNFEGSADLIGQFVDVKITDVFANSLRGEIVRTEKDMDLRSVISPTQMMAKTRREDELGVATFTP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCHX_RHOCB
Sequence: MTDAPNLKGFDARLREEAAEEPTLEIPEQPPTKKTQIIAIYGKGGSGKSFTLANLSHMMAEMGKRVLLIGCDPKSDTTSLLFGGKNCPTIIETATKKKLAGEEVKVGDVCFKSGGVFAMELGGPEVGRGCGGRGIIHGFELLEKLGFHDWDFDFVLLDFLGDVVCGGFGLPIARDMAQKVIVIGSNDLQSLYVANNVCNAVEYFRKLGGNVGVAGIVINKDDGTGEAQAFAREVGIPILAAIPADEELRRKSAAYQIVGSHATPWGKLFEELAGNVADAPPLRPRPLSPDALLALFETDEETRVVDLVPATDEDLRGSNAAPKKSLEVIYDDV
What is the function of this protein?
Converts chlorophylls (Chl) into bacteriochlorophylls (BChl) by reducing ring B of the tetrapyrrole.
What are the official names of this protein?
Chlorophyllide reductase 35.5 kDa chain, Chlorin reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: ACKA_RHOPT
Sequence: MSDVLLVLNAGSSSIKFALYEAHTEPTADHLICEGGIGSLGHRPHFKVVNSDGSTRYDTYLPEGTSHDDAMAVLIGWIETTFPEHRLSAVGHRVVHGGALFDGPVDVTPEVIAQLRAFDRLAPLHQPHNVSAIEALAKLHPSLTQIACFDTAFHHRLPEVATAFALPRELTEQGVRRYGFHGLSYEYIAGRLPDVAGQAVADGRVVVAHLGAGASMCAMLRCRSIATTMGFTALDGLMMGSRCGELDPGVVLYLLEEKSMTAREIEDLLYRESGLLGVSGISDDMRTLLASDDPHACEAIELFVYRIARELGSLAAALGGLDALVFTGGIGEHASEIRRRVCEQAAWLGVTLDPDANARLSGAGRISAPDSKVSAWAIPTDEDLMIARHVWRLADGGR
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELO_BACMK
Sequence: MTNKNETGWNLESSYTVLPKSFFTEIPPTPVHSPELIKLNNSLAISLGFNPEELKKDAEIAILAGNTIPEGAHPLAQAYAGHQFGHFNVLGDGRALLIGEQITPSGERFDIQLKGSGPTPYSRRGDGRAALGPMLREYIISEAMYALDIPTTRSLAVVSTGEPIYRETKLPGAILTRVASSHIRVGTFQYAAARGSIEDLKALADYTIKRHYPEVESTENPYVALLQEVIKRQASLIAKWQLVGFIHGVMNTDNITISGETIDYGPCAFMDSYNQGTVFSSIDTQGRYAYGNQPYMAAWDLARLAESLIPILHEDEEEALKIAQDEISKFSVQYENNWFLGIKKKLGLFSNEEHDQSLIEKLLKAMEKYKADYTNTFRALTDNILENAPLFKSPEFKEWYELWQSRLERQKESKDDAYKLMKNNNPVIIPRNHRVEEALEAAVKDGDYSVMEKLLQALANPYEYSQEQADYCTPPVPSNRPYRTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: ATPF2_PROA2
Sequence: MLTSGIVILSGGLLDPNPGLIFWTAVTFVIVLLILKKFAWGPILGALEEREKAIQSSIDRAHTAKDEAEAALRKNKELLTKADAEAEKILREGKEYGEKLRADIVEKAHSEATKMISSAKEEIEQEKRRALDELRNEVADLAVQGAEKILMANLDADKQKAIVSSMIQDLSKHRN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b 2, ATP synthase F(0) sector subunit b 2, ATPase subunit I 2, F-type ATPase subunit b 2, F-ATPase subunit b 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TAZG_ASPTN
Sequence: MVAFSAILQTALGLSAANDLTSLFGPYLSPQAEILYGNDTNFYAQLQQRWTDYKAPSYGAGAIKPATAKDVQNVVKIANANSIPFFVTGGGHGISDYHNFDGLSIDMGKFNTVERNAAGDRLTIGGAVKIHQLTKPLAEWGKELPLGSCACVGVVGATLGGGIGSLHGLRGLLVDYLEEVEVVTASGDLIKASETEHKDLFWALRGAGSNYGIVTSATYRLPEVTNKGVYVNADYVYPVSANQSFFEVLEQFDNTLPPRLAITGASFFDRVNNKPVIAVNAVFFGPLEEALPHLQPFESLQPEMKNVSSIPAEQMMDAAFFSFFGMDNGACTPNQHINIYTVALRQIHAPTFQSFYSKLVDFWNANPTYQGRLLIQRYSNEGPMAVPDDATAYAYRDVKTYMNIEGFYADSALDDAVNEFATLGRQEFVETSGFDQLAVYSNYARGDEGPVAWYGERKLPKLSALKRKWDPEQRFSVNNPVPLHWRTEL
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of azaterrilone A and other azaphilones, a class of fungal metabolites characterized by a highly oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of bioactivities (PubMed:35398258).  The first step of the pathway begins with the non-reducing polyketide synthase tazA that assembles one acetyl-CoA starter unit, five malonyl-CoA units, and catalyzes a series of Claisen condensations, methylation, PT-mediated cyclization, and finally releases the first hexaketide precursor through the R-domain.  The tazA product then undergoes reduction on its terminal ketone and the following pyran-ring formation by yet undetermined enzyme(s).  Dehydration and enoyl reduction, possibly involving the trans-enoyl reductase tazE leads to the next intermediate.  TazD is predicted as an acetyltransferase and might catalyze the acetylation steps leading to the synthesis of azaterrilone A.  Azaterrilone A is not the final product of the taz pathway and both the highly reducing polyketide synthase tazB and the dual enzyme tazHJ catalyze late steps of the pathway, leading to the production of the 2 final stereoisomers that contain additional polyketide modification whose structures have still to be determined (Probable).
What are the official names of this protein?
FAD-linked oxidoreductase tazG, Azaphilone biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: YJU2_DANRE
Sequence: MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNELYLGLPIFRFYIKCTRCLAEITFKTDPENTDYAMEHGATRNFQAEKLIEEEEKKIQQEREDEELNNPMKVLENRTRDSKLEMEVLENLQELKELNQRQAQVDFEGMLGQYKELEQRQKQREQEEDEQETKEMLERALVKRLRDSDSEEEAENAKERSKKHIADKPTDILTTDTSTSSQGLSSAVAKKQSWDRSVGGLSVKGALGSLVVRKKPADSASKPSHAAPPPAAAAAGTQTGAVKPESSITSSSASSNIQPVSCQNGSSLGLLGAYSDSDDSSSD
What is the function of this protein?
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA.  Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity).  May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453).
What are the official names of this protein?
Splicing factor YJU2.
What is the protein family that this protein belongs to?
Belongs to the CWC16 family. YJU2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TMPPE_DANRE
Sequence: MFGFGRLSAEGKVGIASGVVFFSMLISRTLISERVDKGTRALLFRVQFLLFINSLLLLGSLYLWKRVVKRLCGARAAPSVPQRCWRIIVLLFLALVHGSYLCMFFLVDTEPHWLSLLSFSCLGVYVILLFFLFVFGCLNRLGKLLSRSRSAEEAVASGSFRQTVLALIITAVLAVYGLVNAAQPPKVVDVEIPVEKLPESLNGLRLVLLSDIHLGPTVGRSKLQRIVSMVNELNPDVVVIVGDLTDSQVSRLRSAAEPLGQMKPRLGSYFATGNHDYYTADVEGWFELLHSMGIEALHNSHAKVFRPERTEDWICLAGIDDLEARMLRYPGHGMDVEKALNGCTTEGPIILLAHQPHAAKQALQQRPDISLVLSGHTHAGQLFPLTILAFLMNPFFCGLYRVSEHTMVYVTPGTGYYGIPMRIASRSEITNIVLKQA
What are the official names of this protein?
Transmembrane protein with metallophosphoesterase domain.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. LOC643853 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FPG_RALPJ
Sequence: MPELPEVEVTRLGLLPHITGRRIVRAVVRHHGLRWPVDPALPELLAGLTVTRLLRRGKYLLIECVPEVEQSGRAADTVGGWLLIHLGMTGTLRVLETPVPPGLHDHVDIELAGATGVHVTLRYRDPRRFGAVLWHAGDEAGLAEHPLLRNLGIEPFDARFDGDWMFARTRGRRVAIKSALLAGDIVVGVGNIYCSESLFRAGIRPTTAAGRISRPRYAALADAIRATLADAIARGGSTLRDFVGSDGQSGYFQLEAFVYDRAGLPCRACGTPIRQIVQGQRSTFCCPTCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: VEMP_CVBF
Sequence: MFMADAYFADTVWYVGQIIFIVAICLLVIIVVVAFLATFKLCIQLCGMCNTLVLSPSIYVFNRGRQFYEFYNDVKPPVLDVDDV
What is the function of this protein?
Plays a central role in virus morphogenesis and assembly.  Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport.  Also plays a role in the induction of apoptosis.
What are the official names of this protein?
Envelope small membrane protein, E protein, sM protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses E protein family.
What are the subcellular locations of this protein?
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Protein: RUVB_ROSDO
Sequence: MSDIDPTVRADPLPEDHDRALRPQMLSEFVGQAEARANLKVFIASARQRGEAMDHTLFHGPPGLGKTTLAQIMARELGVGFRMTSGPVLAKAGDLAAILTNLEKRDVLFIDEIHRLNPAVEEVLYPALEDFELDLVIGEGPAARTVRIELQPFTLVGATTRMGLLTTPLRDRFGIPTRLQFYTEDELFIIVDRNARKLGAPADEGGAREIARRARGTPRIAGRLLRRVVDFAVVEGDGRVTRALADMALNRLGVDHLGLDGADRRYLRLIAENYGGGPVGIETMSAALSESRDALEEVIEPFLLQQGLIQRTPRGRMLAQKGWTHLGLDAPRAQTDLFEG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.