PharMolix/UniProtQA huggingface dataset:
Protein: PIP_LACDE
Sequence: MMQITEKYLPFGNWQTYCRIVGEATDRAPLLLLHGGPGSSHNYFEVLDQVAEKSGRQVIMYDQLGCGNSSIPDDQAETAYTAQTWVKELENVREQLGLDQIHLLGQSWGGMLALIYLCDYQPEGVKSLILSSTLASAKLWSQELHRLIKYLPKGEQAAIKEAETTGNYDSLAYQAANAHFMDQHAIKLTPDLPEPVLRKKKGGSLAYLTGWGPNEYTPIGNLHGYEYTDRLKDLHLPALITSGTDDLCTPLVAKSMYDNLPNARWELFAGCGHMPFVQENAKYQELLSDWLISQD
What is the function of this protein?
Releases the N-terminal proline from various substrates.  Has a high specificity towards di- or tripeptides with proline at the NH(2)-terminal position, but is not able to hydrolyze longer peptides, or peptides with hydroxyproline at the NH(2)-end.  Partially hydrolyzes also peptides with alanine, glycine and leucine at the NH(2)-terminal position.
What are the official names of this protein?
Proline iminopeptidase, PIP, Prolyl aminopeptidase, PAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family.
What are the subcellular locations of this protein?
Cell envelope.
Protein: BIOB_RHOP2
Sequence: MNSIDLASLAAATPTLRHDWTREQAAAIYNLPFADLIFRAQTIHRQSFDANEVQCNQLLNVKTGGCAEDCGYCSQSAHHDTALPASKLMDPKKVIEGAKAARDAGATRYCMGAAWRSPKDRDMAPVIEMVKGVKALGMEACMTLGMLTDDQAQQLADAGLDYYNHNIDTSEEFYSSVVKSRSFGDRLDTLATVQDAGIKVCCGGILGLGEKPTDRVEMLRTLANLPQHPESVPINMLIPIEGTPIAKTAKPVDPFEFVRTIALARIMMPKSDVRLAAGRTAMSDEMQSLCFLAGANSIFIGDTLLTTPNPGDSKDRMLFARLGITPREGAPVEAHSHDHDHDHHDHHHGHSHS
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: FTHS_LACPL
Sequence: MKDIEIAQQVTPEPITAIAAKAGLTVDQIDQYGSTKAKLKLPLPVKKTQRNLILVTSINPTPAGEGKSTVTIGLGDALTKIGKSTMIALREPSLGPVMGMKGGATGGGYSQVIPMEDINLHFTGDMHALTAANNTLAALIDNHIQQGNQLGIDQRRIQWKRALDINDRALRHTVIGLGGATSGVPREDGFDITVASELMAILCLSENIADLKQRVNRIVIGYTHDRQPVTVADLNVGGAITLLLKDALRPNLVQTLAHTPALVHGGPFANIAHGCNSVLATQAGLNLADYTVTEAGFGADLGGQKFMDINVPAVGQAPNAVVIVATIRALKLHGGVALQDLATENVAALKAGAANLGHHIHAMQRYGVPVVVAINEFTADTDAEIHAVKDYCADLGVDAVLADVWGRGGDGATDLAAAVVDLCAQPSHFQPLSPADADLKTKINDIVTKTYGGANVEYSAKAQRQLRTFAKQGWDHLPVCMAKTQYSLSDDPKRLGAPTGFTINVREFVPKLGAGFIVALTGNVLTMPGLPKHPAALDMDISDDGKISGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: SHDAG_HDVTW
Sequence: MSQSESKKNRRGGREDILEKWITTRRKAEELEKDLRKARKTIKKLEDENPWLGNIIGIIRKGKDGEGAPPAKRPRTDQMEIDSGTGKRPHKSGFTDKEREDHRRRKALENKKKQLSSGGKNLSREEEEELGRLTVEDEERRRRVAGPRTGDVNLSGGGPRGAPGGGFVPRMEGVPESPFTRTGEGLDIRGNQGFP
What is the function of this protein?
Promotes both transcription and replication of genomic RNA.  Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal.  May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA.  RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity).
What are the official names of this protein?
Small delta antigen, S-HDAg, p24.
What is the protein family that this protein belongs to?
Belongs to the hepatitis delta antigen family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: TAA7D_MOUSE
Sequence: MATGDDSFPWDQDSILSRDLFSATSTELCYENLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGVMVMPFSMVRSVEGCWYFGESYCKFHSCFEGSFCYSSLFHLCFISVDRYIAVSDPLTYPTRFTASVSGKCITFSWLLSIIYSFSLLYTGANDAGLEDLVSALTCVGGCQIAVNQTWVFINFLLFLIPTLVMITVYSKIFLIAKQQAQNIEKMSKQTARASESYKDRVTKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFITPTYVYEILVWIVYYNSAMNPLIYAFFYSWFRKAIKLIVSGKILRENSSTTNLFPE
What is the function of this protein?
Orphan olfactory receptor specific for trace amines.
What are the official names of this protein?
Trace amine-associated receptor 7d, TaR-7d, Trace amine receptor 7d, mTaar7d.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL25_RHOPB
Sequence: MATVKELKATARPAGGKGAARAERRAGRVPGVIYGDNKPPVTISVDDTELRARILAGRFLTTIFDVELDGQKHRVIPRDFHLDPVRDFPIHVDFLRLGEGALIRVSVPLHLKNAEGAPGVKRGGTVNIVTHTVELEAEAESIPQFIEADVSQLDIGSSLHLSDVVLPKGVKTLSREDLTLVTIVPPSGYAEELKAAAAGPAAGAAAPAAAPAAGAKAPAAGAKAPAAGAKAPAAPAAKKK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: ACPS_YERPS
Sequence: MAILGLGTDIVEISRIEAVVERTGERLARRILSPSEWQHYQQHQQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVVNDALGKPTLRLHSRAAELAVELGVKSLHVTLADERRYACATVIIES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_CHLL3
Sequence: MKFTLVGNGRMGREVAAVISRSGIHETAAVLDVDAKITPDSFRGSDAIIDFTVRDAFLQNLDAMLASGVPVVAGTTGWDDVRAGVASKVKAAGGSLLYSANFSLGVNIFLRTVREASRLIAPFEQFDIAFSEQHHTAKADFPSGTALAAAEHILAANSRKHSIVRQLPDGRKIQPDELQVAAIRLGGVFGKHTAFIDSEADEIVISHTAKNRSGFASGAVETAAWLALRHKTAPGFYTMDDFLNERLA
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHHY_CUTCT
Sequence: MTKYSESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRSTKVYNGQADGLQCRTLESLKNLGLADKILSEANDMSTIALYNPDENGHIRRTDRIPDTLPGISRYHQVVLHQGRIERHILDSIAEISDTRIKVERPLIPEKMEIDSSKAEDPEAYPVTMTLRYMSDHESTPLQFGHKTENSLFHSNLQTQEEEDANYRLPEGKEAGEIETVHCKYVIGCDGGHSWVRRTLGFEMIGEQTDYIWGVLDAVPASNFPDIRSPCAIHSAESGSIMIIPRENNLVRFYVQLQARAEKGGRVDRTKFTPEVVIANAKKIFHPYTFDVQQLDWFTAYHIGQRVTEKFSKDERVFIAGDACHTHSPKAGQGMNTSMMDTYNLGWKLGLVLTGRAKRDILKTYEEERHAFAQALIDFDHQFSRLFSGRPAKDVADEMGVSMDVFKEAFVKGNEFASGTAINYDENLVTDKKSSKQELAKNCVVGTRFKSQPVVRHSEGLWMHFGDRLVTDGRFRIIVFAGKATDATQMSRIKKFSAYLDSENSVISLYTPKVSDRNSRIDVITIHSCHRDDIEMHDFPAPALHPKWQYDFIYADCDSWHHPHPKSYQAWGVDETKGAVVVVRPDGYTSLVTDLEGTAEIDRYFSGILVEPKEKSGAQTEADWTKSTA
What is the function of this protein?
Hydroxylates phenol to catechol (PubMed:1429434, PubMed:4146224, PubMed:3203745, PubMed:2022646, PubMed:7858421, PubMed:7851397, PubMed:11591156).  Phenol is the best substrate, but the enzyme also accepts isomeric diphenols, hydroxyl-, amino-, halogen- or methyl-substituted phenols and, to a lesser degree, cresols (PubMed:4146224, PubMed:17425111, PubMed:7851397).
What are the official names of this protein?
Phenol hydroxylase, PHHY.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: IMDH_STAHJ
Sequence: MWENKFAKESLTFDDVLLIPAASDVLPNDADLSVELSERIKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGIEEQAEEVQKVKRSENGVITNPFYLTPDESVYEAEALMGKYRISGVPIVSDKESRELVGILTNRDLRFIEDFSIKISDVMTKENLITAPVGTTLDEAETILQEHKIEKLPLVENGRLEGLITIKDIEKVLEFPHAAKDAHGRLLAAAAIGTSKDTEIRAQKLVEAGVDALIIDTAHGHSSGVIQEVKKMKEKYPEITIVAGNVATAEATRALFEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKFGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEVFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKTPRKFVPEGIEGRTAYKGPLQDTIYQLMGGVRAGMGYTGSPDLKTLRDEAQFTRMGPAGLAESHPHNVQITKESPNYSF
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: CFBD_METTH
Sequence: MHPRPSPIAASLYTLRDLDADVIILHGPHGCCFRTGRLLETDGVRVLTTAMSEQDFIFGASDKLTETLRKAYEMFSPKLVGVVGTCASMIIGEDLKEAVQRAGIPARVLAVESHGGFGEGDNTEGAIIVLEAAAEQGIIPEEEAERQIKMLKLATEIEKTRGMAQGKYIRPSYGDDKDEVALRVLEAIMEGRRVAFVLNAKKETSYLFADTLTLPFGSLNPDNPPIIIANLDKGIGLPRIRRHAENILSEIERSGNRVEHITGGLDEYPITGARAAEILRNEEIEFAVVSGVPHALPVEELGLESVAVTDGPRLVEPLRGLGYTHVVAELDAHARTLGQRSIVESDFGDALRRNIKKVI
What is the function of this protein?
Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation.  Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c-acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430.
What are the official names of this protein?
Ni-sirohydrochlorin a,c-diamide reductive cyclase complex, component CfbD, NifD homolog component CfbD.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: AMERL_PONAB
Sequence: MGKRRCVPPLEPKLAAGCCGVKKPKLSGSGTHSHGNQSTTVPGSSSGPLQNHQHVDSSSGRENVSDLTLGPGNSPITRMNPASGALSPLPRPNGTANTTKNLVVTAEMCCYCFDVLYCHLYGFPQPRLPRFTNDPYPLFVTWKTGRDKRLRGCIGTFSAMNLHSGLREYTLTSALKDSRFPPLTREELPKLFCSVSLLTNFEDASDYLDWEVGVHGIRIEFINEKGVKRTATYLPEVAKEQDWDQIQTIDSLLRKGGFKAPITSEFRKTIKLTRYRSEKVTISYAEYIASRQHCFQNGTLHAPPLYNHYS
What are the official names of this protein?
AMMECR1-like protein.
Protein: GCSH_LEGPH
Sequence: MNDLKFTTTHEWLREDEEEVTVGITDHAQELLGDMVFVELPEIGDEVSAGQELGVVESVKAASDFYAPISGVVTAVNEAVGKNPALVNHDPYHEGWLVKLKPSHPDEIKSLLSDEQYQNEIAEEN
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: DNAJ_STAAW
Sequence: MAKRDYYEVLGISKDASKDEIKKAYRKLSKKYHPDINKEEGADEKFKEISEAYEVLSDDNKRASYDQFGHDGPQGFGGQGFNGSDFGGFSGFGGGGFEDIFSSFFGGGRQRDPNAPQKGDDLQYTMTLTFEEAVFGTTKEISIRKDVTCETCHGDGAKPGTSKKTCSYCNGAGHVAVEQNTILGRVRTEQVCPKCNGSGQEFEEACPTCHGKGTENKTVKLEVKVPEGVDNEQQIRLAGEGSPGVNGGPAGDLYVVFRVKPSETFKRDGDDIYYKLNVSFPQAALGDEIKIPTLNNEVMLTIPAGTQTGKQFRLKEKGIKNVHGYGYGDLYVDIKVVTPTKLTDRQKELMKEFAQLNGEEINEQPSNFKDRAKRFFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPJC_ECOLI
Sequence: MLVSKSNGFNASAVLGSGSYNENKSSKHMELLAHSILKLICKEAASETYRGALETLQKMMSECIYQEGNAFVIMGAGEQLKRIKYEVGENNLKVFNVHFNNNHELVSSGEPDVICLSKQVWENLLIKLKLENNENVFSETKKLSNKNNADQFFECAKRNE
What are the official names of this protein?
Protein YpjC.
Protein: LDH2_BIFLO
Sequence: MAETTVKPTKLAVIGAGAVGSTLAFAAAQRGIAREIVLEDIAKERVEAEVLDMQHGSSFYPTVSIDGSDDPEICRDADMVVITAGPRQKPGQSRLELVGATVNILKAIMPNLVKVAPNAIYMLITNPVDIATHVAQKLTGLPENQIFGSGTNLDSARLRFLIAQQTGVNVKNVHAYIAGEHGDSEVPLWESATIGGVPMCDWTPLPGHDPLDADKREEIHQEVKNAAYKIINGKGATNYAIGMSGVDIIEAVLHDTNRILPVSSMLKDFHGISDICMSVPTLLNRQGVNNTINTPVSDKELAALKRSAETLKETAAQFGF
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase 2, L-LDH 2.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYNX_ECOLI
Sequence: MLLVLVLIGLNMRPLLTSVGPLLPQLRQASGMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSSALLGGVGIGIIQAVMPSVIKRRFQQRTPLVMGLWSAALMGGGGLGAAITPWLVQHSETWYQTLAWWALPAVVALFAWWWQSAREVASSHKTTTTPVRVVFTPRAWTLGVYFGLINGGYASLIAWLPAFYIEIGASAQYSGSLLALMTLGQAAGALLMPAMARHQDRRKLLMLALVLQLVGFCGFIWLPMQLPVLWAMVCGLGLGGAFPLCLLLALDHSVQPAIAGKLVAFMQGIGFIIAGLAPWFSGVLRSISGNYLMDWAFHALCVVGLMIITLRFAPVRFPQLWVKEA
What is the function of this protein?
This protein is part of an active transport system that transports exogenous cyanate into E. coli cells.
What are the official names of this protein?
Cyanate transport protein CynX.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CHSB_IPONI
Sequence: MSTILNVLTDTWSPRAKKLEGDAKIWAIGTATPANWVDQTTYPDFYFRITNSQHLLEHKEKFRRICNKSKIRKRHLVLTEELLKKNPNLCTYNETSLNTRQDILVAEVPKLGKEAAMKAIKEWGRPISEITHLVFCTTSGVDMPGADFQLTKLLGLNSSVKRLMMYQQGCNAGAAMLRLAKDLAESNKGGRVLVVCAEITINIFRGPSLEQDDNLLAQCLFGDGAAAMIVAADPRPGLETPLFELVSSAQTIVPNTDSHLKLHLREMGLTFHCSKAVPSVLAENVEDCLVKAFEPYGISDWNSIFWVFHPGGNAIVDRVEERLGLGPEKFRASRDVLSEYGNLTSACVLFTLDEMRKKSKKDE
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase B, Naringenin-chalcone synthase B, CHS-B.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: VATD_STRZJ
Sequence: MVRLNVKPTRMELNNLKERLTTAERGHKLLKDKRDELMRRFISLIRENNQLRKEVESYLIDNLKSFAVAKSLKNSQMVEELFSIPSKEIELFVEKENIMSVTVPRMHMNITSQNENSEYSYLSSNSEMDDVFATMNSLIYKLLRLAEVEKTCQLMADEIEKTRRRVNGLEYSIIPNLSETIHYIELKLEEAERANLVRIMKVK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: RS2_THEP3
Sequence: MSVISMKQLLEAGVHFGHQTRRWNPKMAPYIFTERNGIYIIDLQQTVEKLEQAYEFVKKLAMEGGTILFVGTKKQAQDSIKEEAERCGMFYVNQRWLGGTLTNFKTIRGRIQRLKELKKMEEDGTFDVLPKKEVIKLRKEKERLQKFLGGIENMESLPSALFIVDPKKEAIAVAEARSLEIPIVAIVDTNCDPELIDYPIPGNDDAIRAVKLITSKIADAVIEGNQGEQFAASEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: IRTA_MYCS2
Sequence: MARGIQGVMMRGFGARDHQATVVSTEAITPNLLRLRMVSPTLFEDAVAEPTSWLRFWFPDPAGSKTEFQRAYTMSEMSPETGEFAIDVVLHEPAGPASRWARSAKPGDAIAVMTLGSAGFSVPEDPPAGYLLIGDAAATPAINGIIGVVPHDIPIEVYLEEHDENDRLIPIAEHPRMRVHWVVREDATSLAGAIEARDWSNWYCWVTPEAGSLKHLRTRLRDEFGFPKAELHPQAYWTEGRAMGTKRGDDDKTPEVNPAPRADKPEAPAPAAAGRGNWRAQAAGRLLAPLKTTLIISGVLQAIITLVQLAPFVLLVELARLLLSGASSDRLWTLGVVAISLLGTGSFLAAALTLWLHLVDARFARDLRTGLLTKMSRLPLGWFTARGSGSIKQLVQDDTLSLHYLITHAIPDAVAAVIAPVAVLVYLFVVDWRLALVMFVPVLIYLVLMTVMTIQSGPKIAQSQRWAERMSAEAGAYLEGQPVVRVFGGAAASSFRRRLDEYIGFLVAWQKPFTGKKSMMDLVTRPGTFLWLIVAVGTPMITSGAMDPVDILPFLLLGTTFGVRLLGIAYGLGGIRGGMLAARRIQTTLDETELVIREQTGKRDGEPAVVFDNVTFGYRPDIPVLHDISLQLTPGTVTALVGPSGSGKSTLAALLARFHDVDAGAIRLGGRDIRTLTADELYRQVGFVLQDTQLVGGTVAENIALADPDASIERIQDAARDAQIHDRIMRLPNGYDTPLGAASSLSGGEKQRLTIARAILADTPVLILDEATAFADPESEYLVQQALNRLTRDRTVLVIAHRLHTITHADQIVVLEGGRIVETGTHERLLDAAGRYRQLWETGQRPALATAAGPTGEAVR
What is the function of this protein?
Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:32296173).  Has a preference for Fe-MBT over Fe-cMBT (PubMed:32296173).  Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell (PubMed:32296173).  Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (PubMed:32296173).
What are the official names of this protein?
Mycobactin import ATP-binding/permease protein IrtA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Siderophore-Fe(3+) uptake transporter (SIUT) (TC 3.A.1.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LT_POVM1
Sequence: MDRVLSRADKERLLELLKLPRQLWGDFGRMQQAYKQQSLLLHPDKGGSHALMQELNSLWGTFKTEVYNLRMNLGGTGFQGSPPRTAERGTEESGHSPLHDDYWSFSYGSKYFTREWNDFFRKWDPSYQSPPKTAESSEQPDLFCYEEPLLSPNPSSPTDTPAHTAGRRRNPCVAEPDDSISPDPPRTPVSRKRPRPAGATGGGGGGVHANGGSVFGHPTGGTSTPAHPPPYHSQGGSESMGGSDSSGFAEGSFRSDPRCESENESYSQSCSQSSFNATPPKKAREDPAPSDFPSSLTGYLSHAIYSNKTFPAFLVYSTKEKCKQLYDTIGKFRPEFKCLVHYEEGGMLFFLTMTKHRVSAVKNYCSKLCSVSFLMCKAVTKPMECYQVVTAAPFQLITENKPGLHQFEFTDEPEEQKAVDWIMVADFALENNLDDPLLIMGYYLDFAKEVPSCIKCSKEETRLQIHWKNHRKHAENADLFLNCKAQKTICQQAADGVLASRRLKLVECTRSQLLKERLQQSLLRLKELGSSDALLYLAGVAWYQCLLEDFPQTLFKMLKLLTENVPKRRNILFRGPVNSGKTGLAAALISLLGGKSLNINCPADKLAFELGVAQDQFVVCFEDVKGQIALNKQLQPGMGVANLDNLRDYLDGSVKVNLEKKHSNKRSQLFPPCVCTMNEYLLPQTVWARFHMVLDFTCKPHLAQSLEKCEFLQRERIIQSGDTLALLLIWNFTSDVFDPDIQGLVKEVRDQFASECSYSLFCDILCNVQEGDDPLKDICEYS
What is the function of this protein?
Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation.  Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA.  Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.  Participates in the modulation of cellular gene expression preceeding viral DNA replication.  This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53.  Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.  Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression.  Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters.  Initiates viral DNA replication and unwinding via interactions with the viral origin of replication.  Binds two adjacent sites in the SV40 origin.  The replication fork movement is facilitated by Large T antigen helicase activity.  Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization.  Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription.
What are the official names of this protein?
Large T antigen, LT, LT-AG.
What are the subcellular locations of this protein?
Host nucleus.
Protein: PSMA3_STAAE
Sequence: MEFVAKLFKFFKDLLGKFLGNN
What is the function of this protein?
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
What are the official names of this protein?
Phenol-soluble modulin alpha 3 peptide.
What is the protein family that this protein belongs to?
Belongs to the phenol-soluble modulin alpha peptides family.
Protein: NDHS_ARATH
Sequence: MATSSITIPTIRTPIHRSKFLGQTHQFSTVNRSVFPPPKQQSKLYQVKAMGKFNLWEVMGGRGLCNGEKGIEKELQRNIEDEQETSKAENNETERESDDSNLSFKVPEDGFEKEMMGLTGGFPGGEKGLKTFIEKNPPPPPPPPPAKQGSDASAVATDKKPKAPKLPLLMPGMIAIVKNQNSPYHMYCGIVQRITDGKAGVLFEGGNWDRLITFRLEELERREKGPPGKNPKSCILEPLIEQMQKEEAAP
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable).  Required for the efficient operation of ferredoxin-dependent plastoquinone reduction.  Forms the electron donor-binding subcomplex in association with the NDHT and NDHU subunits (PubMed:21505067, PubMed:24225949).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit S, chloroplastic, NAD(P)H dehydrogenase subunit S, NDH subunit S, NADH-plastoquinone oxidoreductase subunit S, Protein CHLORORESPIRATORY REDUCTION 31.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: DPCHF_COLHI
Sequence: MKLSFIASPVWALALAQFAAATQVKIDVDVAIFGGGSAGIHAAIQLRDAGATVAVIEKKSQIGGHAETYTDPQGKSTNVGVVVFDNIEVASNYFARLNVSIVRGSPLGTAGPTYTYDFTSGAQIPAVNTSAEAQQQLTAALQSYSTNVLSKYPWIDEGFLVPDPVPEELTIPFGELAQKYNFTALMPTIAMYNYFTGDLSTIPSLYGIKGLGQGALKNLFGSFILPASGKTRDLYDAAAIELGNSVLLNADVVKVQRDVRINSTTTGVTVLIQQPGQPPKLIRARKLLVAAPPTLENVGAFDLTAEERGLISKFSSLGCWASVANVPGLNVTLKNYGVHMPYNQPSIPGPYGFVAYGSPNNFLVTVGLPDAANTAAKGEAVVRQSLATLSAVGAVPADALEKLTFPFSAVHSPYSLRVSAEEIKAGFYSKFLALEGARNTYWTGAVWAGHNSALIWNFNMGTVLPGLKKDLGL
What is the function of this protein?
FAD-dependent oxidoreductase; part of the gene cluster that mediates the biosynthesis of the diterpenoid pyrones higginsianins A and B (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpchA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpchD through the action of the prenyltransferase dpchC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpchE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpchB (Probable).  The short chain dehydrogenase/reductase dpchG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpchH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Finally, the FAD-dependent oxidoreductase dpchF converts higginsianin B into higginsianin A (PubMed:32286350).
What are the official names of this protein?
FAD-dependent oxidoreductase dpchF, Diterpenoid pyrone biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the beta-cyclopiazonate dehydrogenase family.