PharMolix/UniProtQA huggingface dataset:
Protein: KPSE5_ECOLX
Sequence: MLIKVKSAVSWMRARLSAISLADIQKHLAKIIILAPMAVLLIYLAIFSQPRYMSESKVAIKRSDDLNSGSLNFGLLLGASNPSSAEDALYLKEYINSPDMLAALDKQLNFREAFSHSGLDFLNHLSKDETAEGFLKYYKDRINVSYDDKTGLLNIQTQGFSPEFALKFNQTVLKESERFINEMSHRIARDQLAFAETEMEKARQRLDASKAELLSYQDNNNVLDPQAQAQAASTLVNTLMGQKIQMEADLRNLLTYLREDAPQVVSARNAIQSLQAQIDEEKSKITAPQGDKLNRMAVDFEEIKSKVEFNTELYKLTLTSIEKTRVEAARKLKVLSVISSPQLPQESSFPNIPYLIACWLLVCCLLFGTLKLLLAVIEDHRD
What is the function of this protein?
Involved in the translocation of the polysialic acid capsule.
What are the official names of this protein?
Capsule polysaccharide export inner-membrane protein KpsE.
What is the protein family that this protein belongs to?
Belongs to the BexC/CtrB/KpsE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YTYK2_DICDI
Sequence: MFNNDKDDNNQGNENNENNKINIKTSIDMGNYINSSSLVESFGSGSNRNNDKSEDVEYDDDDDDDDDEIASTEEEKESDLDSDSDLAPTQIIVDDSDDFYNNNNGGGGGGGNEDISSTSPTLITSNSFNDKINQIFSRGGSSLNSSFLNNGENKINFKQLVKLKSTLKKHEIPSRELTVEKEIGQGFFGKVYKARWRGKSVALKKITLIKFRDLTETEIFDKEVSIMSKLCHPTCVMFIGACSLDGPSNDRSIIMEYMEGGSLRRLLDEKSSYHLPPSLQLSIARDIAEGMNYLHTNFKEGPIVHRDLTSSNILLNSSYTVAKINDFGLSKEMKPGPTEMTAAMGSLAWMAPECFKAENYTEKVDVYSFAIILWEIVTCRDPYNGMEPLRLAFLASVEDYRLPLNGFPPYWVELISKCWNITPSLRPSFKEILQILNQIESDPLFLNLNLNCSSNNTSSGSTSTSSGSSSSSDNNLTKSSESNNNLRESNINNQIKSNKNSSKNGYYAQDINDYSLSMQVETKNCIYNNVSDNVNNNNNNNNNNNNDNDFFKSSFTKKSFLSNNNYNNNNNNINNKNNNTNNLNDNLIIKSLNHISEQNSFLVSYQDSNIVKYFSLDNESLTSTLQMEQSVVCMKYQIINEKVFLVVAMSNNNISLFELKKTDFSGSANSPTTLLPIKVIKCDEQRHTIKDITWNGTHVITSSFKDSSIQIWDLEKSLYPISKMDNGGVGILSIDSQSHQPLMISGDSDGKVKLWDIRNSHCFRTLTHSPPSSSSGGSIGVDSVLFRSPHAVRDPIILTGSSKDCKFKVWNMYSSTCLNSFQSHNKDLLGIHRNQSSQQMITWSSEGTISLFNSGNNINNQNNQNNNNDCGNDNDSVEFSKVLNVNSMMSNEPLQSAQIISKNRIIFSSKNKFYSIIA
What are the official names of this protein?
Probable tyrosine-protein kinase DDB_G0283397.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Tyr protein kinase family.
Protein: CITG_STRP8
Sequence: MTKAVLTSISQLALKALLYEVSLSPKPGLVDRFDNGAHDDMSFMTFIDSMIALSPFFQAYIETGFAYAKEEPLLLFNRLRQLGQKAEETMFCATQGINTHKGLNFSMALLLGATGAYLARTPHLMTDLGCFSKEDTLAICRLVKPMTAHLIQADLGHLNTKKEFTYGEQLFVTYGIKGPRGEASEGFTTLTNHALPYFRQMISQNDPETSQLRLLVYLMSIVEDGNLIHRGGIEAWKGVKADMRLLLQQDLSTTDLRLALSSYNQCLINQHLSPGGAADLLALTFYFAFLEKLL
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: LEPA_SHEPW
Sequence: MKHIRNFSIIAHIDHGKSTLSDRLIHECGGLTDREMAAQVLDSMDIERERGITIKAQSVTLDYKANDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTALEMDMDVVPVLNKIDLPQADPDRVAEEIEDIVGIEAADAVRCSAKTGVGIKDVLEVIVEQIPPPEGDEEGPLQALIIDSWFDSYLGVVSLVRIKNGVLKKGDKFKVMSTGQNHTADRVGIFTPKQTDTPELKTGEVGFVIAGIKEIHGAPVGDTLTHAKHGALEPLPGFKKVKPQVYAGLFPISTDDYESFRDALNKLSLNDASLFFEPETSSALGFGFRIGFLGLLHMEIIQERLEREYNLELITTAPTVVYEIVQTNGETIYVDNPSDLPAINNIEEMREPIVETNILVPKEYLGNVITLCVEKRGVQTNLVYHGNQVALTYELPMAEVVMDFFDRLKSTSRGYASLEYNFVRFEPADMVRLDILINGDRVDALAMIIHKGLIRSKGLALVNKMKELIPRQMFDIAVQAAVGSQIIARSSIKAMRKDVTAKCYGGDVSRKKKLLQKQKDGKKRMKQVGNVEVPQEAFLAVLKLND
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: WAXS4_ARATH
Sequence: MEEELMSLIKVWVYAIISISYCYYTSTRIKSGVFRLLSVLPVCVLFLVLPLFVSSVHFSGSTAFFLSWLANFKLILFSFDQGPLFPVPSNLSRFVCFTCFPIKLQQNPKPQNQMPKWGFAVKLAFFGVLLHMYEYKQHMSPTVLLVLYSLHIYLEYEILLAPLKVLLSISLWCDLEPHFNEPYLSTSLQDFWGRRWNLMVPAILRPAVYLPVRQMAGRKMNSDQALFLGVFASFLVSGVVHELIFFYFTRESPTGEVTLFFVLHGVCTAAECAAKRTRLVRRWKVSQMVSRLLTVGFVVMTGGWLFFPHLARSGMIERLADEAFLFIGFVKHKFFYLCRNQSLKS
What is the function of this protein?
Catalyzes the final step in the synthesis of long-chain linear esters (waxes).
What are the official names of this protein?
Probable long-chain-alcohol O-fatty-acyltransferase 4, Wax synthase 4.
What is the protein family that this protein belongs to?
Belongs to the wax synthase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: REM6_ARATH
Sequence: MNNPTLFSPKSPHFFQPLLPGFKSHINIPVKFFSKYIKGKHEGKTVKLRSDSSKRTWKVKIEGHTLTDGWKEFVEAHDLRISDFVIFKHKGDMFFDVTALGSSCWESSRKEKEIEENIETEPDQFSSDLTCFSQSVTTSNLMRDSVGVPRDFAKRYGFNIGRHEIVLMNEEGKPWESEVISYKSGKVIVAGGWKSLCTESKLEVGDSCTFKLLHNAKMPVFRLCSKLPKAGAEARPLKRARVQRWSQESRSKHDVREKIAEEGEPSRRNRTSNKSTGDQGKLQQTQSCFIFDHVAKSLPRNFVRSDGLIKGSNKIVLMNEGARTWTLILKFRDSRRSFYSRGGWRSFCRENGLKPGDSVTFKLESSNTKTPLLLFSIAESKSASTKDRTRFLTLTVTPSSIRSSRLYLSKKFISVNKMERAGGKKITLLDKNGEEWPVTLLMDKRYTRMVLGSGLREFCNAIGVKAYESVVLELVWEETTTLPMFKFCSKIKT
What are the official names of this protein?
B3 domain-containing protein REM6, Protein REPRODUCTIVE MERISTEM 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: VP3_CTFVL
Sequence: MAQLLFRKTTQDFRDCFGLKHEILASIYNEKSTFSSENGSIQILEEAEVNALGELVRDGTVAISFGPGIYSRMFSHLRDDSDYRSALTDCVAHGWKQTRDARDVREWQRSAAIMCAERYMYKVRQAYKRVVENLDHMYAWHYLTEGPSEHVFILPAMYESVRHETTSEAYGMQCGGIIGGNVSLMLPRDEQYTTLFKAWLMSLAKMSLSELREPHWNGVRVQLSRDHRILYYGDLLPSDGDITYLVNKLEYHTIWFPEGDFETMMGAMLRDSFPAGCHAHLNIPVPHYFVFDTDDDLILRCWKGVRDTWIKLRLGYEEGGVNDSRMSEALIVNRDLPADLSESLFCCCLARGVSRDQVRTLKDVRNVAQAQIRHVVSGQGVWWEHMVRGQPLACSIRPGKVVLVVDYEDGPLHVSIRVRLLNVHYARELGMKASDVVVRIPTSNRPRWVETKEYERSLRFYEFRPGPITTEFHHVFAFYCYWGCGRVEKRRHLYQIREVRRGNLYSRSRFLRRIAEDGEKVKVQGRTHVTATRAVQHEKCNPNEDIIYSREFARELALTGKIKEAGALAVIYTCMQTLGVDIDPPAGWVREGRPKQRTAKLCHLLTRILTAFFSYRGGSSSLVCSVMVVIFSIILYYLRLKHVDQEVRYDELTLIWYGDGGVELQRILREVSMTRFVAVAGDPATPEYIAQAKLWANKKSNIVVFNYARPYERGPVFENLIRDTVSLREAAEVFILRTDDSWSQYGNTVVAMLGEGDFCDLVHFGASCDPMEHYFVHISQPPGTNPGYEPANQEEPFEEWLYETQAMERVIPTTWESEIVDARGMLVSILTFHFRFAGWFELDVPGDDIGRGLQLMGSINKVVHVSCFVQNGRRYFRLSVDLDVDRVLRNMRHEGDALMAAELFVTDAVLVCEGLVVGEMHRLQRTYRSVNAMVYHQGMTNFIVYEWMRRVLLTNLLDEMLVFDIGGRNGELSGWVVQDVKVHYFCVDPAGEEAIPKGQRVRLPGGRAIWDIAETVEQNVARYLEVVGKPQTPAEGIILIFSNSIVAAYEAAGRNNRNQVANLYQQLQAWGGRVFIRDQLVPTRANPGDYWIQAAFPGNVYPPGLCEDFNIDPDAGILPLRYPDTGQGATDVVLANGRLGHLTSSWFQSLYCGAARGFILNGFGRLIWPIYCRHVVVLATRP
What are the official names of this protein?
Uncharacterized protein VP3.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RF1_GEOMG
Sequence: MFDKIEELEIRYQELESLLAVPTVIANQPEFRKLSREHNDLTGLVEAYRRYKKVLAEIEGNRELLADPEMKEMAEAELEDLERQQEELEGEIKLLLLPKDPNDDRNVILEIRAGTGGDESALFAGDLFRMYSRFAERNRWKVEVMSASESERGGFKEVVALIEGQAVFAKLKYESGTHRVQRVPETEAQGRIHTSACTVAVLPEAEDIEIDINPVDLKIDVYRASGAGGQHVNKTESAVRITHLPTGIVVECQDERSQIKNRSKAMKVLKSRILDGLQQEQNARIAADRKQQVGSGDRSERIRTYNFPQGRMTDHRIGLTLYRLDALMEGDIAEVVDSLRAHYQMEALKAQAEAA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTC6_LACTC
Sequence: MNRVVYGLLLTLVLNVVRGQSFWPALSSDSLIALRSQRDVLSNISIDKVPMVGVQLNEVAFRGTSNETESLEILASLLNVGVQAYMMDIEFDESYNLTISGSDTSLGTTLSTFKRFISSSNNYLNADMLVLLLRLKQNTNTSTKGAPSNFPNITAILDLYLGSSTLYTPSQLAYDRSSGNVAPSYGNLNSPDWPSLNYFLYSIQKRAVVFYVDTASSDALQSPAIFNASNLNYETSNTPIVCPLTNNAQVLNTSSLSWRFLQKDYSPSDIREYTMCGYSPIIDNKYNPNSINTISNVLENSLLWSWASNEPNTSDDTRSNSTSLVARRCAVVHYTKSNSSSYWTVANCYDRKRALCKRDGNDFEWAVTQEGASYFSHHDQDGNGFCPDNFSLSLPQTALQEKSLDNYLSQLSPEGWEIWIDLNSVSVPDCWVPDGPYASCPYQKEVSTRNFVSMITPVSVFAAVTILMLIMLSWRRVPIQDNRKRWKRVINSHLGSKAEGVPA
What is the function of this protein?
May be involved in telomere capping.
What are the official names of this protein?
Maintenance of telomere capping protein 6.
What is the protein family that this protein belongs to?
Belongs to the MTC6 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TRP3_PENRU
Sequence: GPSSGFFGMR
What are the official names of this protein?
Tachykinin-related peptide 3, TKRP-3.
What are the subcellular locations of this protein?
Secreted.
Protein: END4_PHOV8
Sequence: MKKIGAHVSVSGGVEMAPVNALGIGADAFALFTKNQRQWVAKPLSVESVTLFKENCEKEGFDARYVLPHDSYLINLGHPDEEGLEKSRAAFLDEMQRCELLGLKMLNFHPGSHLNKISIEKCLDRIAESVNMTLDKTTGVTAVIENTAGQGSNVGNEFWHLRYIIDKVEDKSRVGVCLDTCHTYTAGYDIVNEYDRVFTEFDEVVGRNYLCAIHLNDSKKPLGSRVDRHDSIGKGLIGIDFFRRFMQDSRFDDMPVILETPDDTIWRDEIKMLRSFES
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: DAPB_PSEAE
Sequence: MRRIAVVGAAGRMGKNLIEAVQQTGGAAGLTAAVDRPDSTLVGADAGELAGLGRIGVPLSGDLGKVCEEFDVLIDFTHPSVTLKNIEQCRKARRAMVIGTTGFSADEKLLLAEAAKDIPIVFAANFSVGVNLCLKLLDTAARVLGDEVDIEIIEAHHRHKVDAPSGTALRMGEVVAQALGRDLQEVAVYGREGQTGARARETIGFATVRAGDVVGDHTVLFAAEGERVEITHKASSRMTFARGAVRAALWLEGKENGLYDMQDVLGLR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYH1_RAT
Sequence: MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
What is the function of this protein?
Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6.  Promotes the activation of ARF factors through replacement of GDP with GTP.  Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
What are the official names of this protein?
Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog A, rSec7-1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Cell junction, tight junction. Cell junction, adherens junction. Note=Colocalized with TJP1 during epithelial polarization.
Protein: ARGB_MORAB
Sequence: MTMKATMTTPLVLKLGGALLQNETALEQLFTALSEYKSTCTSLILVHGGGCFVDDLLAKMNIESEKKNGLRITPASDIGYITGAYVGTANKVLMAQGIKLGFNVVGLTLADGGISTVTLSTAGLGAVGECEAGDPTLLTALLSGGFLPIISSIGIDAQGLLLNVNADQAATAICETLDADLVMLSDVAGILDADMQLIAEMNSHYADELIMAGVIHGGMEVKVKAALKAAASLNRDIKLASWKVPERLVALLNGEAEGSKVSS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M231_CONVE
Sequence: MMSKLGALLTICLLLFPLTALPLDGDQPADRPAERMQDDISSEQHPLFDKERQCCTGSCLNCWPCCG
What are the official names of this protein?
Conotoxin VnMMSK-02.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MMP17_HUMAN
Sequence: MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQALTL
What is the function of this protein?
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin.  May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha.  May also be involved in tumoral process.  Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site.  Not obvious if able to proteolytically activate progelatinase A.  Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
What are the official names of this protein?
Matrix metalloproteinase-17, MMP-17, Membrane-type matrix metalloproteinase 4, MT-MMP 4, MTMMP4, Membrane-type-4 matrix metalloproteinase, MT4-MMP, MT4MMP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
[Isoform Long]: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
Protein: TRUD_ALISL
Sequence: MSDIMSTFSWLYGKPVATGKLKQLPEHFIVKEVLGYEFTGKGEHLMVKIRKTGENTKYVANEFAKFCGVKSKDISWAGLKDRHAVTEQWLSVHLPKSDHLNFVLFEVAHPGVEILEMTRHHKKLRPGDLLGNSFQLIATEVTDMDDVLARLEKVKVTGVPNYFGAQRFGHEGNNVTEARRWGRENVRTRDNTKRSFYLSAARSWIFNHIISQRITEGYFSLPVDGDILLDQNDRTVNENVTSEDCIQKIKKGELSISAALAGDNQLPTTEKALMFEQPQLDAEPDLMALIRGNRMRHERRSIELHPENLHWSVEGDQLTLNFSLTSGSFATVIVRELLQEIEVERTYD
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: HTPX_HAEIN
Sequence: MMRILLFLATNMAVMLVLGIILSVTGIAGNSTGGILIMALLFGFAGSLISLFLSKTMALRSVDGEVITQPRNQTERWLIDTVSRQAQKAGIPMPDVAIYHSPDVNAFATGATKSNSLVAVSTGLLNNMTEAEAEAVLAHEISHISNGDMVTMALLQGVLNTFVIFLSRVIATAVASSRNNNGEETRSSGIYFLVSMVLEMLFGVLASIIAMWFSRYREFRADAGSASLVGKEKMIMALQRLQQLHEPQNLEGSLNAFMINGKRSELFMSHPPLEKRIEALRNL
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RAB7B_MOUSE
Sequence: MNPRKKVDLKLIIVGALGVGKTSLLHQYVHKTFFEEYQTTLGASILSKIIILDDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDPESFEALDIWRDDVLAKIIPMEQSYPMVVLGNKIDLEDRKVSQEVVHGWCKEKDMPYFEVSAKNDINVVQAFEVLASRALLRYQGTAENHLIDSIKLSPGQPKSRCC
What is the function of this protein?
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN).  Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation.  Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4.  Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1.  Not involved in the regulation of the EGF- and EGFR degradation pathway.
What are the official names of this protein?
Ras-related protein Rab-7b.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Late endosome. Lysosome. Golgi apparatus. Golgi apparatus, trans- Golgi network. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or Mycobacterium.
Protein: WOX11_ORYSJ
Sequence: MDGGHSPDRHAAAAAGEPVRSRWTPKPEQILILESIFNSGMVNPPKDETVRIRKLLERFGAVGDANVFYWFQNRRSRSRRRQRQLQAQAQAAAAAASSGSPPTASSGGLAPGHAGSPASSLGMFAHGAAGYSSSSSSSWPSSPPSVGMMMGDVDYGGGGDDLFAISRQMGYMDGGGGSSSSAAAGQHQQQQLYYSCQPATMTVFINGVATEVPRGPIDLRSMFGQDVMLVHSTGALLPANEYGILLHSLQMGESYFLVTRSS
What is the function of this protein?
Transcription factor involved in crown root development (PubMed:19258439, PubMed:26307379, PubMed:29740464).  Promotes the development of crown roots (both initiation and elongation), main components of the fibrous root system (PubMed:19258439, PubMed:26307379, PubMed:29740464).  Regulates the expression of genes required for crown root development, and hormone-responsive genes involved in cytokinin signaling (e. g.  RR1, RR2, RR3 and RR4), and auxin signaling (e. g.  IAA5, IAA11, IAA23 and IAA31) (PubMed:26307379).  Functions dowstream of the auxin biosynthetic genes YUCCA1 in the promotion of crown root development (PubMed:29740464).  Recruits the ADA2-GCN5 histone acetyltransferase (HAT) module to regulate crown root cell proliferation and stem cell maintenance of root meristem (PubMed:28487409).  Together with the ADA2-GCN5 HAT module targets and regulates a set of root-specific genes involved in carbon metabolism, cell wall biosynthesis, and auxin transport and response (PubMed:28487409).  Functions upstream of several genes controlling root development, cytokinin homeostasis/signaling, stress response, and redox metabolic processes (PubMed:28830102).
What are the official names of this protein?
WUSCHEL-related homeobox 11, OsWOX11.
What is the protein family that this protein belongs to?
Belongs to the WUS homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: POLS_SLDV
Sequence: MFPMQFTNSAYRQMEPMFAPASRGQVQPYRPRTKRRQEPQVGNAAIAALANQMSALQLQVAGLAGQARVDRRGPRRVQKNKQKKKNSSNGEKPKEKKKKQKQQEKKGSGGEKAKKPRNRPGKEVRISVKRARQSTFPVYHDGAISGYAVLIGSRVFKPAHVKGKFDHPELADIKFQVAEVMDLEAAAYPKCMRDQAAEPATMMDGVYNGEYGNIQEWRTILYSMRAAEASRGDSGRPFTDNSGKVVGIVLGGGPDGRRTRLSVIGFDKKLKAREIAYSEAIPWTRAPALLLLPMVIACTYNSNTFDCSKPSCQDCCITAEPKKAMTMLKDNLNDPNYWDLLIAVTTCSSARKKRAVSTSPVAVYDTQILAAHAAASPYRAYCPDCDGTACISPIAIDEVVSSGSDHVLRIRVGSQSGVTAKGGAAGETSLRYLGRDGKVYAADNTRLVVRTTAKCDVLQATGHYILANCPVGQSLTVAATLDGTRHQCTTVFEHQVTEKFTRERSKGHHLSDLTKKCTRFSTTPKKSALYLVDVYDALPTSVEISTVVTCNERQCTVRVPPGTTVKFDKRCKNAAKETVTFTSDSQTFTCEEPVLTAASITQGKPHLRSSMLPSGGKEVKARIPFPFPPETATCRVSIAPLPSITYEESDVLLAGTAKYPVLLTTRNLGFHSNATSEWIQGKYLRRIPVTPQGIELMLGNNAPLHFWSSVRYASGDADAYPWELLVHHIKHHPEYAWAFVGVACGLLAVAACMFACACNRVRYSLLANTFNPNPPPLTALTAALCCIPGARADQPYLDIIAYLWTNSKVAFGLQCAAPVACMLIVTYALRHCRLCCNSFLGVRGWSALLVILAYVQSCKAYEHTVVVPMDPRAPSYEAVINRNGYDPLKLTIAVNFTVISPTTALEYWTCAGVPVVEPPHVGCCTSVSCPSDLSTLHAFTGKAVSDVHCDVHTNVYPLLWGAAHCFCSTENTQVSAVAATVSEFCAQDSERAEAFSVHSSSVTAEILVTLGEVVTAVHVYVDGVTSARGTDLKIVAGPITTDYSPFDRKVVRIGEEVYNYDWPPYGAGRPGTFGDIQARSTNYVKPNDLYGDIGIEVLQPTNDHVHVAYTYTTSGLLRWLQDAPKPLSVTAPHGCKISANPLLALDCGVGAVPMSINIPDAKFTRKLKDPKPSALKCVVDSCEYGVDYGGAATITYEGHEAGKCGIHSLTPGVPLRTSVVEVVAGANTVKTTFSSPTPEVTLEVEICSAIVKCASECTPPKEHVVAARPRHGSDTGGYISGPAMRWAGRIVGNPSGPVSSSLAVTYCVVKKCRSKRIRIVKS
What is the function of this protein?
Class II viral fusion protein.  Fusion activity is inactive as long as E1 is bound to E2 in mature virion.  After virus attachment to target cell and endocytosis, acidification of the endosome would induce dissociation of E1/E2 heterodimer and concomitant trimerization of the E1 subunits.  This E1 trimer is fusion active, and promotes release of viral nucleocapsid in cytoplasm after endosome and viral membrane fusion.  Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane.  Fusion is optimal at levels of about 1 molecule of cholesterol per 2 molecules of phospholipids, and is specific for sterols containing a 3-beta-hydroxyl group.
What are the official names of this protein?
Structural polyprotein, p130.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm. Host cell membrane. Host nucleus. Note=Shuttles between the cytoplasm and the nucleus. SUBCELLULAR LOCATION: [Spike glycoprotein E2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [6K protein]: Host cell membrane; Multi-pass membrane protein. Virion membrane; Multi- pass membrane protein. SUBCELLULAR LOCATION: [Spike glycoprotein E1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: SYM_CROS8
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIAEMSKEHQTDFAGFNISYDNYHSTHSDENRVLSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTVSFDEYWKKDSDAELYHVIGKDIVYFHSLFWPAMLEGSGFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYAAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFIAKRFDGELAAELADPALYQTFTDAAAVIGEAWESREFGKAIREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPELCARAEAFLNVELTWDGVNAPLLGHKVNSFKALYNRIEMKQVEALVEASKEEVKAAAAPVTGELAENPIQETITFDDFAKIDLRVALIENAEFVDGSDKLLRLTLDLDGEKRNVFSGIRSAYPDPQALIGRLTVMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDSGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLP1_ASHGO
Sequence: MSAIQSTQELLQPIGFDTPVAESKTVLLSPGKEWRARIPAESKLTIKIVYGIAELFGTELANGVEYTIQCANIAVYSVDHVKLEWKSLDELETTVSPDTNMPYLYNLHFALEKMRLSSFDGPRILVVGKASSGKTSLCKILCSYALKSKAYTPIYVNLNPQEGAFSPPGFLTATPISDILDVESTMWGQSMTTGATKLHNKQPMVKNFGLEMIAENRPLYMEVLGQLAQTVDGRLKNDPLVRRSGVIVDSPPLQHLDESYTELEVAITKFNIKTLVVCAPDDSLAVELSDRFQTLVRSIVRIPTSRGICNIDDVARRALQRSQIREYFYGNGSTVLSPYTIGVDLLDAVVWRPKSSLTIDMSKTSPNMVELERVEVTAANLQHALVAITYAPRKSTAEEVFRSGVLGVALITEVNDAKRKMRILLPVPGRLPDKAMILTAYRYLE
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
mRNA cleavage and polyadenylation factor CLP1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.