PharMolix/UniProtQA huggingface dataset:
Protein: CAD13_MOUSE
Sequence: MQPRTPLTLCVLLSQVLLVTSADDLECTPGFQRKVLHIHQPAEFIEDQPVLNLTFNDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVGRTLFVHARTPHAEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPEGSKFRLTGKGVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDASGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIVIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTKQENISVGSVLLTVNATDPDSLQHQTIRYSIYKDPAGWLSINPINGTVDTTAVLDRESPFVHNSVYTALFLAIDSGNPPATGTGTLLITLEDINDNAPVIYPTVAEVCDDARNLSVVILGASDKDLHPNTDPFKFEIHKQTVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCKNSKVDCNGAGALHLSLSLLLLFSLLSLLSGL
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.  May act as a negative regulator of neural cell growth.
What are the official names of this protein?
Cadherin-13, Heart cadherin, H-cadherin, Truncated cadherin, T-cad, T-cadherin.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: DEF_HYPNA
Sequence: MAIREILTVPDPRLKQVSKPVEGGVTDDIRALMDDMLETMYDAPGIGLAAIQIGVPLRVIVMDLAREGEEPAPRYFVNPEILETIEEKKPYEEGCLSVPDIFDQVERSARCRIRYLDYDGKQVDEWAEDLYAVCIQHEMDHLEGTLFIDYLSRLKRDRAIDKVKKAKIRAIREDAN
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: DGTL1_AGRVS
Sequence: MTIDRNALGFGVGERAIFAADPWNSRGRLYPEGGSLTRSDFQRDRDRIVHTTAFRRLKHKTQVFIGPDSDHYRTRLTHTIEVAQIARALARAFRIDEDLAEGVALVHDFGHTPFGHTGEDALHELLEPYGGFDHNAQSLRIVTKLERRYAEFDGLNLTWETLEGLVKHNGPLMNADGEGTRGPVPLPITEYCQMQDLDIASHASLEAQAAAVADDIAYNTHDIDDGLRSGYLTFDMLEDVPFLAGLMRDVRDRYPNLEADRFTHEIMRRQITRMVEDVIAVAQERLARIRPMSADDIRQAGETVITFSEGMAETDRQIKKLLFSKIYRHPDIMRIRAGAAQIVTDLFKAYMADPTLMRSDYWVEHTAGLETPAKARHVGDFLAGMTDTYAVRVHRQLFDHTPDLR
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: KDPB_XANAC
Sequence: MSTIDTTEKRERGDAALFDAAVLVAAMRAAFAKLAPRHLLRSPVMAVVMGGTVLAAVITASGHSHAGFGWAVTAILFVTVLFGNFAEAIAEARGRGQAASLRRARKDLVARRVETALGGRETRVPAAELRPGDYVMVSEGEFVPADGEIVRGVATINEAAVTGESAPVLREAGTDRSGVIGGTRVLSDEIVFKVTAEPGHSFLDRMIALVEGANRQKTPNEIALTLLLAAMTLTFLIVVASLPAIAGFVGVTLDPLLLIALLVCLIPTTIGGLLPAIGIAGMNRALSANVLAKSGKAVEVAGDVDVLLLDKTGTITYGDRQATAFHPLAGVDRVQLRDAAMLASLADPTPEGKSIVKLARQQGAIAVEAEGGDFIAFTAQTRMSGVDIGGRSIRKGAGDSIVAYVQAQGATVSPELQGRIEEVARGGATPLVVAEGRHVLGVVELSDVVKQGIKEKFAQLRAMGIKTVMITGDNPLTAAAIAAEAGVDDYIAQARPEDKLARIRAEQTGGRLVAMVGDGTNDAPALAQADVGLAMNSGTQAAKEAGNMVDLDSDPAKLLAVVEVGKQQLITRGALTTFSLANDVSKYFAILPALFAAAIPSMAALNVMQLSSPRHAVLAALIFNALIIPALIPLALRGVRFRPSSATALLRRNMMIYGVGGVLLPFAAIKAIDLALVAVLGA
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPIA_AERHH
Sequence: MTQDEMKKAAGWAALKYVVPGTIVGVGTGSTVNHFIDALATMKDEIKGAVSSSVASTERLKGFGITVYDLNEIDALSVYVDGADEINGTRDMIKGGGAALTREKIVAAVADKFICIIDNTKTVDVLGTFPLPVEVIPMAREYVAREIRKLGGNPVWREGVVTDNGNHILDVKGMAITDAKGLEVQLNAIVGTVTNGLFAHRGADVVLIGTPDGVITQ
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: RLMN_PSEE4
Sequence: MTTSTGKINLLGLTLAEMEQFFDSIGEKRFRAGQVMKWIHHFGVDDFAAMTNVGKVLREKLEAVAEIRGPEVVSEDISADGTRKWVVRVASGSCVETVYIPTDDRGTLCVSSQAGCALDCSFCSTGKQGFNSNLTAAEVIGQVWLANKSFGTVPAKIDRAITNVVMMGMGEPLLNFDNVIAAMKIMMEDLGYGISKRRVTLSTSGVVPMIDELAKHIDVSLALSLHAPNDELRNKLVPINKKYPLKMLLESCMGYMSTLGGKRVLTIEYTLLKDVNDQPEHAAQMIELLRDVPCKINLIPFNPFPHSGYERPSNNAIRRFQDLLHHGGFNVTTRTTRGDDIDAACGQLVGQVNDRTRRSERYIAVRQLADEPQDSAARP
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIG1_ASHGO
Sequence: MQNVASWLLALVVAVVQGELLPGKSAPALLWSYKLSEGIQEYQLAYNMTTVLPAPEFNAIALELLDHCNSHAYVFVNQPGLRLEDFDYEDAWTVLPNYLSRSSSALRFEQVEVSPSNVFENLIAHTKRRCDVQREIILRAEQTNQFEPYIDAQSRIIQVHFSPLPGDGRNERPSREDVLADHDQRLRRILGRLPSPAVTVIYTSLEPADRLSASPPRAGIFPEIFEHESRRIEYERNDRDLQVNRYFPSHHPKMEPIEEVELSLLDPKFIQSNLKLLKLIAVSAIGSLTWQLYSLFSPKLPVATPKGTAKRQKGQKKLVKLATAQAAKQAEEVKLEVSQQEKED
What is the function of this protein?
Required for normal beta-1,6-glucan synthesis.
What are the official names of this protein?
Protein BIG1.
What is the protein family that this protein belongs to?
Belongs to the BIG1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: HTF_NEORO
Sequence: QVNFSPNW
What is the function of this protein?
Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).
What are the official names of this protein?
Hypertrehalosaemic factor, Adipokinetic hormone 1, NeoRh-AKH-1, Hypertrehalosaemic neuropeptide.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXC_ACIBC
Sequence: MVKQRTLNRVVKASGIGLHSGQKVMINFIPHTVDGGIVFRRIDLDPPVDIPANALLIQEAFMCSNLVTGDIKVGTIEHVMSAIAGLGIDNLIVEVSASEVPIMDGSAGPFIYLLMQGGLREQDAPKKFIKILKPVEALIDDKKAIFSPHNGFQLNFTIDFDHPAFAKEYQSATIDFSTETFVYEVSEARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFADEFVRHKILDAVGDLYLLGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDEKDCPIPYVSVT
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: TRMB_CAMJR
Sequence: MPNFKSKKIKEINLPYSKDDVEFLWLAKNDNVSLIYTKVQEESFFLQIKKAQNGFVIKGDKHTKPSKIGYLQKALKIFKEGFCEDIINEAFGLKNNALIEKTPFIVDNFDELLSRLQGKIYIEIGFGSGRHLLYQAKENPNVLILGVEIYNPALTQVAKLAKAQNVNNILLIQSDARLLLSVLKSKSVEKIFLHFPVPWDKKPHRRVIGKDFCKECARVLTQNGRFELRTDSFEYFNFTLEQFLTFPVPKFSLRKNENLEISSKYEDRWKKQEKNIYDLWVWNFNQECKNYELNEFNLSSVEFSKEDLKKIEQNFKNITIKKDDFFLHFESIYKQDENLLLKVAFGAFNKPEHCYLHLDKTIDFAFKEPFKIQENIKAINELKEILKVQFKI
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RECA_RALSO
Sequence: MEDGKKAASMSAEKQKALAAALAQIEKQFGKGSIMKMGDAEVEPVQVVSTGSLGLDVALGVGGLPRGRVVEIYGPESSGKTTLTLQVVAEMQKLGGTCAFIDAEHALDVTYADKLGVKVPDLLISQPDTGEQALEIADALVRSGSVDLIVIDSVAALVPKAEIEGEMGDALPGLQARLMSQALRKLTGTIKRTNCLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGSIKKGDEVVGNETKVKVVKNKVAPPFREAIFDILYGAGVSREGEIIDLGVEAKVVEKSGAWYSYNGERIGQGRDNCREFLRENAELAREIENKVREHLGVTPMGAVTLAEEVEED
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_FRAP2
Sequence: MNSQEKLLKTVVRPHVSDKTYGLSDANSTIVFEVARTATKQDVKSAVEKLFEVKVESVNILNVKGKARRFGRVEGRTKAWKKAYVKLAEGHDINFVGAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: LGBA_PHAVU
Sequence: MGAFTEKQEALVNSSWEAFKGNIPQYSVVFYTSILEKAPAAKNLFSFLANGVDPTNPKLTAHAESLFGLVRDSAAQLRANGAVVADAALGSIHSQKGVSNDQFLVVKEALLKTLKQAVGDKWTDQLSTALELAYDELAAAIKKAYA
What is the function of this protein?
Provides oxygen to the bacteroids.  This role is essential for symbiotic nitrogen fixation.
What are the official names of this protein?
Leghemoglobin A.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: RL31_ECOL5
Sequence: MKKDIHPKYEEITASCSCGNVMKIRSTVGHDLNLDVCSKCHPFFTGKQRDVATGGRVDRFNKRFNIPGSK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: JIP5_MALGO
Sequence: MDIALSSDALDVSFHPDEGVHQIAVGLISGKVQLFDYGAMFHNQSTQPDESRTSGKAYRRVWSVRPSHKSCRGVAFDASGSNLFCIFKDKSIIALDPSDGHVKARWPRAHESAPSRILPIHEGLMATGDDDGIVRLWDPRCPPEGDAEAKPLRSYDHHSDWITDMLWCTHLDPPRSKKKDQEDDLKRKRDEERARSRLIVTSGDGTLSVIDIHGGKKGVEVSEDQEDELLSIASIKNGKKLVVGTQLGVLSLWAPDRGLLDHADRFPGHPSSVDALCTLDQDTVLTGSSDGLIRVVQLFPHKLLGIVGDHGGMPIECMKRKGHLIASIGHGNECKLTDLAPLLEEGDVETDAAEPEPAVMLVSDEAHLIARSADGSDESAGESDVMQPPPATKRRTAKSKAGKKSVHDVDQHASFFADL
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SIP1_YEAST
Sequence: MGNSPSTQDPSHSTKKEHGHHFHDAFNKDRQGSITSQLFNNRKSTHKRRASHTSEHNGAIPPRMQLLASHDPSTDCDGRMSSDTTIDKGPSHLFKKDYSLSSAADVNDTTLANLTLSDDHDVGAPEEQVKSPSFLSPGPSMATVKRTKSDLDDLSTLNYTMVDETTENERNDKPHHERHRSSIIALKKNLLESSATASPSPTRSSSVHSASLPALTKTDSIDIPVRQPYSKKPSIHAYQYQYLNNDETFSENSQMDKEGNSDSVDAEAGVLQSEDMVLNQSLLQNALKKDMQRLSRVNSSNSMYTAERISHANNNGNIENNTRNKGNAGGSNDDFTAPISATAKMMMKLYGDKTLMERDLNKHHNKTKKAQNKKIRSVSNSRRSSFASLHSLQSRKSILTNGLNLQPLHPLHPIINDNESQYSAPQHREISHHSNSMSSMSSISSTNSTENTLVVLKWKDDGTVAATTEVFIVSTDIASALKEQRELTLDENASLDSEKQLNPRIRMVYDDVHKEWFVPDLFLPAGIYRLQFSINGILTHSNFLPTATDSEGNFVNWFEVLPGYHTIEPFRNEADIDSQVEPTLDEELPKRPELKRFPSSSRKSSYYSAKGVERPSTPFSDYRGLSRSSSINMRDSFVRLKASSLDLMAEVKPERLVYSNEIPNLFNIGDGSTISVKGDSDDVHPQEPPSFTHRVVDCNQDDLFATLQQGGNIDAETAEAVFLSRYPVPDLPIYLNSSYLNRILNQSNQNSESHERDEGAINHIIPHVNLNHLLTSSIRDEIISVACTTRYEGKFITQVVYAPCYYKTQKSQISN
What is the function of this protein?
Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation.  Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex.  Promotes the PKA-regulated relocalization of the SNF1 kinase complex to the vacuolar membrane in response to various types of carbon stress.
What are the official names of this protein?
SNF1 protein kinase subunit beta-1, SNF1-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the 5'-AMP-activated protein kinase beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side. Note=Resides in the cytosol during growth in glucose and relocalizes to the vacuolar membrane in response to carbon stress.
Protein: QUEA_CHLPD
Sequence: MKVSDFDYELPESHIARYPPDERGSTRLLVLQRSTGEIMHSRYAGLHGFLRKGDLLVLNNSRVVKARMFAFKPTGGKIELVLLEKHGDEQNLVLYRGSLKKGDALLAYGCEFGVEELVGQGVAVLSVKGEGTVQDVFERYAAMPIPPYLKREAEEIDRERYQTVFAEQPGSVAAPTASLNMTGELFDSLRQKGVSIASMTLHVGLGTFLPIRVDHFDEHVMHREFYVIPDETIALIRTTKNNGGRVIAVGTTVTRALEHAADVVFNSNGNGSVSGEADIFIYPGYRFRVIDALLTNFHAPRSTVLMLTAAFAGAEKLFHAYAEALRWEYDFLSYGDSMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RXRBA_DANRE
Sequence: MGDSRDSRSPDSSSVSSPPSGQRSPPLAPSAAAMTSLPPITSAVNSPISSMGSPFSVISSSLGSPCLPGTPSVGYGPISSPQINSTVSMSGLHAVSSSDDVKPPFGLKPLSSHSPGPMVSQKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLSYTCRDNKDCLVDKRQRNRCQYCRYQKCLAMGMKREVVQDERQRSVQEERQRNKERDGEVESSSAANEEMPVEKILEAEMAVEQKTELHADGSSGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELSLDDQVILLRAGWNELLIASFSHRSITVKDGILLATGLHVHRNSAHSAGVGAIFDRESAHNAEVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIILFNPDAKGLSSPSEVELLREKVYASLEAYCKQRYPDQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLT
What is the function of this protein?
Receptor for retinoic acid.  Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.  The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5.  The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity).
What are the official names of this protein?
Retinoic acid receptor RXR-beta-A, Nuclear receptor subfamily 2 group B member 2-A, Retinoid X receptor beta-A.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RN138_BOVIN
Sequence: MAEELSAATSYTEDDFYCPVCQEVLKTPVRTAACQHVFCRKCFLTAMRESGIHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSETSASDNIETYQENTGSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQVTRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
What is the function of this protein?
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination.  Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination.  Two different, non-exclusive, mechanisms have been proposed.  According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination.  According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP.  Together with NLK, involved in the ubiquitination and degradation of TCF/LEF.  Also exhibits auto-ubiquitination activity in combination with UBE2K.  May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF138, RING finger protein 138, RING-type E3 ubiquitin transferase RNF138.
What are the subcellular locations of this protein?
Chromosome. Note=Recruited at DNA damage sites. Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers.
Protein: VP5_LBVAV
Sequence: MAERCFEAAMTYMIPNKQSVEVFEGLLGILDPVLTSKHVRRVYQEITVSFLMISLISDQVDSKGIVRMSDSQGDDDDSLSSLTWNSKNKLWGFLVNPVPITSSDLEKRLRISCMISSNAYRIGTNVAQVRFLLRIGTFPLVLSRELGFLCPSSSRFPSVIFVSPDKQTEMLRIISSYYSVGDTEEKNCWGILGERYLTTISEDISNLVVMAFPFLQGAFHCSSVYYLNFGCKMAAEGFHAIAREELRIALSNPVLWSDCPLKRVYDSLLQRIPTGVHISHSEEKGDPTFLPLAEYCSSHRECWICGDLKLGVDRGIGADFRHLSERRTSSPDGLDAVMSAVSRMIYHHWSIPSWVSGAFKIAKFIGAH
What are the official names of this protein?
Protein 5.
Protein: THIC_NAUPA
Sequence: MRTEWIKKRMNDKTRTQMYYAKKGIITEEMEYVAKEENLDPELVRSEVARGRLIIPANINHKHLKPMAIGRVSKTKVNSNIGASALASDIEEEVRKLETSVKYGADTVMDLSAGAKNMDEIREAIIAASPVPIGTVPMYQIIDEIGDVLELTYDDILRVLEKQAKQGVSYFTIHAGLLLRHMPEIAKRKMGIVSRGGSLTASWMLKHHKENPFYTIFDDILDICKEYDVSLSLGDSLRPGCLYDASDKAQLEELKVLGELTLRAWDKDVQVMIEGPGHVPINEIERNVRLEQIYCHEAPFYVLGPLVLDIGAGYDHIGSAIGAAMAAWYGVSMLCYVTPKEHLGLPNEEDVREGMLAYKIAAHSADIARKIPGARDKDDEMSDARYKFDWKKQFELALDPERAKEYHDETLPQEVFKEAEFCSMCGPKFCSYKVTQDAMENFDWDEFKKEAEEKMKAEANN
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: H2B_AJECA
Sequence: MPPKAAEKKPSTAGKAPAGKAPEKKEAGKKTTAAGGEKKKRSKTRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSAK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RS3_RICPU
Sequence: MGQKVCAHGFRVGPTLIKGWDSILYAEKHYKTLFIQDLKIRDLINKGFNQAQISRVLIERPSNKSIIININAKKPNIIIGRNGSEIDKLKKAIEKMTSLKEVYINIHEVRKFNIDAAIVAQTIALQLEKRVSFRKAMKTAIQASFKQGGQGIRVSCSGRLGGAEIARTEWYIEGRMPLHTLRADIDYSTAEAITTYGVIGVKVWIYKGEYTENKRYN
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: NCAP_I86A1
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYKRVDGRWMRELVLYDKEEIRRIWRQANNGDDATRGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGIGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFSARSALILRGSVAHKSCLPACVYGPAVSSGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRLLSFIRGTKVSPRGKLSTRGVQIASNENMDNMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFEKSTVMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RNH2_METLZ
Sequence: MTICGVDEAGKGPVLGPMITAGVLVSDMSELEMLGIKDSKKLSPKKRESLFEEITFSWKTYTVVRTPFDIDSREGTMNAFTASCHADVVRALCADFVYLDACDVNAKRFGENVLRLSGSSAHVCSEHKADAKYAVVGAASIVAKVTRDRCIADLKEEYGEIGSGYPSDPATISFLTEYIRTRGEVPLCARRSWQTVQDILDRASQTGLSDFF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.