PharMolix/UniProtQA huggingface dataset:
Protein: TISD_HUMAN
Sequence: MSTTLLSAFYDVDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAPSSGFAPGFLRRHSASNLHALAHPAPSPGSCSPKFPGAANGSSCGSAAAGGPTSYGTLKEPSGGGGTALLNKENKFRDRSFSENGDRSQHLLHLQQQQKGGGGSQINSTRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGASGDLRAFGTRDALHLGFPREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSCSSASSCSSSASSCSSASAASTPSGAPTCCASAAAAAAAALLYGTGGAEDLLAPGAPCAACSSASCANNAFAFGPELSSLITPLAIQTHNFAAVAAAAYYRSQQQQQQQGLAPPAQPPAPPSATLPAGAAAPPSPPFSFQLPRRLSDSPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD
What is the function of this protein?
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510).  Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868).  Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868).  Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510).  Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868).  Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs).  Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA.  Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA.  Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation.  In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation.  Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.
What are the official names of this protein?
mRNA decay activator protein ZFP36L2, Butyrate response factor 2, EGF-response factor 2, ERF-2, TPA-induced sequence 11d, Zinc finger protein 36, C3H1 type-like 2, ZFP36-like 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.
Protein: YOPT_YERPS
Sequence: MNSIHGHYHIQLSNYSAGENLQSATLTEGVIGAHRVKVETALSHSNLQKKLSATIKHNQSGRSMLDRKLTSDGKANQRSSFTFSMIMYRMIHFVLSTRVPAVRESVANYGGNINFKFAQTKGAFLHKIIKHSDTASGVCEALCAHWIRSHAQGQSLFDQLYVGGRKGKFQIDTLYSIKQLQIDGCKADVDQDEVTLDWFKKNGISERMIERHCLLRPVDVTGTTESEGLDQLLNAILDTHGIGYGYKKIHLSGQMSAHAIAAYVNEKSGVTFFDPNFGEFHFSDKEKFRKWFTNSFWDNSMYHYPLGVGQRFRVLTFDSKEV
What is the function of this protein?
Cysteine protease, which is translocated into infected cells and plays a central role in pathogenesis by cleaving the C-terminus end of the human small GTPase RhoA/ARHA, a regulator of cytoskeleton.  Once cleaved, ARHA loses its lipid modification, and is released from the cell membrane, leading to the subsequent disruption of actin cytoskeleton of the host cell.
What are the official names of this protein?
Cysteine protease YopT.
What is the protein family that this protein belongs to?
Belongs to the peptidase C58 family.
What are the subcellular locations of this protein?
Secreted. Note=In infected cells, it is cytoplasmic. Translocated into the host cell by the type III secretion apparatus with the help of the SycT chaperone (By similarity).
Protein: RL4_CLOBK
Sequence: MPKIDLFNQNGEKVGDLQLADSVFGVEVNTYAMHQVVKALLANKRQGTQSAKTRAEVSGGGIKPWRQKGTGRARQGSIRAPQWIHGGIVFAPKPRDYRMSIPKSMKKVAMKSALTSKVNEKLMVVVDDIKLETPKTKEVVKMLNSFDAKKTLIITNNAEENVYKSARNIEGVQIIPVNNINVYDLLKYDKVVITKDAVSKIEEVYA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TRMFO_KORVE
Sequence: MNLKIRIIGAGLAGCEAAWQCARRGLDVELYEMRPVKSTPAHQTSDFAELVCSNSLKSAGENSAPWLLKEEMRRGGSLLLEIAQKTSVPAGHALAVDRGAFAAEVTRVIEAEPRIRVVRGEVTKIDENDALTVIATGPLTSDALSQEIARLSGNTHLYFYDSISPIVEADSIDMSRVYMAARYDKGTADYINCPMNKEEYDRFLDALIEAHSVDAKEWENLNYFEGCLPIEEIARRGRDTLRFGPMKPVGLTDPKTGRYPYAVVQLRQENLRADSYNLVGFQNHLKYGDQARVMRLIPGLENAKFLRYGQIHRNTYINSPTLLTETLRMKEHPNVFFAGQISGVEGYVESIATGQMAGMHVSTVAMGHEPVAPPRATAFGSLVNYICHAEAKHFQPANITFDLLPQLDEAARRKVRDKKERHRMVCEAALKEFDGWLATSQIFQ
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_NOSS1
Sequence: MARINPLEKVRNIGIAAHIDAGKTTTTERILFYSGIIHKIGEVHEGTAVTDWMDQERERGITITAAAISTSWKDYQINIIDTPGHVDFTIEVERSMRVLDGVIAVFCSVGGVQPQSETVWRQADRYKVPRIAFINKMDRTGANFYRVHEQMRDRLRANAIAIQLPIGSENDFKGIVDLVRKRAYMYNNDQGTDIEETDIPADLQDQVEEYYTKLVEAVAETDDDLMSKYFDGEPLTEEEIRSALRKGTIAGTIVPVLCGSAFKNKGVQLMLDAVVDYLPAPTEVPPIQGTLPNGDAIERRADDNEPLAALAFKIMADPYGRLTFVRVYSGVLKKGSYVLNATKNKKERISRLVLMKADDRQDVEELRAGDLGAALGLKDTLTGDTITDEGAPVILESLFIPEPVISVAVEPKTKNDMDKLSKALQSLSEEDPTFRVNVDPETNQTVIAGMGELHLEILVDRMLREFKVEANVGAPQVAYRETIRKPVTNVEGKFIRQSGGKGQYGHVVINLEPGEPGTGFEFVSKIVGGVVPKEYIGPAEQGMKESCESGILAGYPLIDVKATLVHGSYHDVDSSEMAFKIAGSMALKEAVLKASPVLLEPMMKVEVEVPEDYIGNVIGDLISRRGQIESQSTEQGLAKVASKVPLATMFGYATDIRSKTQGRGIFTMEFSHYEEVPRSVAETIIAKSKGNA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEPI_ECOK1
Sequence: MSEFIAENRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMKKS
What is the function of this protein?
Involved in the efflux of purine ribonucleosides, such as inosine and guanosine.
What are the official names of this protein?
Purine ribonucleoside efflux pump NepI.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PCCB_RHOER
Sequence: MTILAPVTKSESSTDPRDPLARLENLFDPGTTVPLHARDKSGVLAASGNIDGVRTIAYCSDATVMGGAMGVDGCKHLVKAIDTAIEEESPIVGLWHSGGARLAEGVEALHAVGLVFEAMVRASGLIPQISVVLGFAAGGAAYGPALTDVVIMAPEGRVFVTGPDVVRSVTGEQVDMVSLGGPDTHTKKSGVAHIAAHDEADALHRARRLVSMMCEQGEFDQRAAELGDSDLRAMMPASAKRAYDVRPIVHEMLDNVEGESSFEELQGNYARSIVTGFGRMAGRTVGVIANNPLRLGCLNSESAEKAARFVRLCNAFGVPLVVVVDVPGYLPGVSMEWEGVVRRGAKLLHAFAEATVPRVTVVTRKIYGGAYIAMNSRALGATAVFAWPNSEVAVMGAKAAVGILHKRALAAAPDDEREALHDRLAAEHEAIAGGVDRRCRNRRRRRGNRPGEDSQHRHAALASAPSVRARHKNIPL
What are the official names of this protein?
Propionyl-CoA carboxylase beta chain, PCCase, Propanoyl-CoA:carbon dioxide ligase.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
Protein: SET26_CAEEL
Sequence: MADGEHTLPADEELFEQPPLQQQQPEIAEPIVMAQEPIQGVSEDPQASEATHEAPDNYPVDHQMENQEFYQEPQIPEPQQIPQIPVFQPAAYNPPNYVAPQQRANNFGEPAAAADSRPLTEEEQLAAERPTEDTVWIDSDDDTDVEEAILRANFWLPYSDHNYDPPDPADRIILPTEGPFPCIAGLDEDCNIVKQWMPEDAVGPGSPGTQYRRNQQTGGGLPSTSVAPQQQQLPVRHNIQNRPMVAAQPFSIGGNQVEYGGIGGMDSRMQQRGVVRDGPQYRVMNDFGNGLPMRGQLPPRNSPAANAINRVREQQQQMYHQAGARGSLQQRVPAPAAPTPGSYQHIVNAVPVGGANPMRRVPPQARPGMIGGAANNNRARPIHVTRPMDTQEFEHPVAPAAAAPPRRVVDVAPHRMTPEQRQELQQMNRQRAAPQFPAAAAQRSAEKIVIQQRPGASSSRAPRPSMAQEDLLRSPTRRLSERVPQEHQTPVLEPRRFQVKVTDTYSTPIPKASDQLPAQLTEEDPPEESAAAAAPEDVPDAAPEDPPKGILKPTPPHRMTQEEKNAHFARLTTDKEKPTSSASILPQDAAPPHVPPPPPPPLVLRPHHQDETLAMVQSVFESKPRQPDTPKDKEAISKIADLLRFSADEFTGQSGSSAAARQRTVSGSAARAQTYQMHHQQQQQHHHQMPMDQRKRHSSGRYDALMGAMPLQQQPPPPPPSQFQHTDSIAHRPRGRPKGTRHPSVAVQPQRSGGARTLPPRAQTVAMSARNGANAKNSDSESEGIDEAAEESWTMRCHCGMDHGDGDTIECEGCKTWQHMACMGLTLKSNTSKYKCEMCLPRRLPVSKAEAAREQERILNRLRAAAKKQKRKSEPVEQKQKSQPSTSRKSAPMALQQQPAEPRVAQLNDYSKQASALLFGMEQTAGADTLLAESRLHKKARRMFVEEAVEALVTTDLVQIRQVILEVNGHVSMSNEVKRQPGGGNCIFMYDGLMKGTAGEDMGDGQELVCIDTKRKGNDTKFTRRSCVPNCVLKHVLGSNATLGIMIVATKDITRNTEVTLPFDADWRESEVELECAEHMKELQACPFESERRRFAAERHRAMDHKKREAEEARRADEERRRLEEEVRRERAAKTKQMDEAEKARLEAEKAAEKEKKAKEREEAKERKKMEVEASAAAAPESSNSITAREERRIQQAEEMFRRQEEEGKRKEARRRSKSVTPGVLEAAGTAAREDAPEASIPAPAPSPPASRRSVSRTTQPSTSSFATPTEPPAKNKRMRSVVPPKSEPASSAKRVRATTVATPKDTTASNDSRKRKSSATGKTPVAKRSKNVVPTSFGLALIEKELREQARDSTVLEMILPDYIMKEKRSGLLAGQSPDFSEVRAQIEEENRMKERFTKREAKKKAVEKAKEKEKKEHRKEPKKANEPGPAPKSEKAVEKAVEKVEKKPKSPQKPPAKPTAQKPPLKKTEEVDGIEREASESSSKESSVAPEEKKNPKKITFAEYNSRRSQKREAGECSTPPAVTRRGFIPSTEGEDLVNVELSAIPLDDHPSSSNTAPTTTIAPSVGGAPKPTSVVVKSPSTRSRTRGAASESVDDAPAEHSMSLQDRVFSMFGSTVDAPAPPPPPPASAETNSRRSRSTRWN
What is the function of this protein?
Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro (PubMed:24685137).  Involved in transcriptional regulation (PubMed:29714684).  Plays a role in the negative regulation of lifespan and in heat resistance (PubMed:29714684).  Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion (PubMed:22212395, PubMed:29714684).  Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline (PubMed:29714684).  Together with spr-5, required for transgenerational fertility (PubMed:24685137).
What are the official names of this protein?
Histone-lysine N-methyltransferase set-26.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: WDR59_CHICK
Sequence: MAARWSSENVVVEFRDAQATAMSVDCLGQHAVLSGRRFLYIVNLDAPNEGHRKISRQSKWDIGAVQWNPHDSYAYYFAASSNQRVDLYKWKEGNGEVCTSLQGHTRVISDLDWSVFEPDLLVTSSVDTYIYIWDIKDTRKPTVSLSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDNEYTLATSSQDNSVRFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRIDSQLQRLCANDILDGVDDLIDGISLLPEPDKALQPQDSEPQHSSGHGDEEALKEDFLNDLLVGKKTDQLGLPQTLQQEFSLINVQIRNVNVEMDAVNRSCTVSVHCGNHRVRMLVMFPVQYPNNAAPSFQFINPTSITASMKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSWLESVVNQEDSTSSNPYALPNSVTTPLPTFARVSNAYGSYQDSNIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHSGLITPMKIRTETPGNLRLYSGSPTRSEKEQVSISSFYYKERKSRRWKSKREGTDANNRPIKAAGKVIIQDISCLLPVHKLLGELYILNVNNIQETCQKNAASAMAVGRRDLVQVWSLAMVATDLCLGPKSDPDLEIPWAQHPFGRQLLESLLAHYSQLHDVQTLAMLCSVFEAQSRLQGCPNSYGPFPQRASNLASHSRYPSFTSSGSCSSMSDPGLGTGGWSIANKDTEQTSTPWCESSPDEFRYSNLMYPDHREREKDQHEKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSSPPDPHKGIEFGVYCSHCRSEARGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF
What is the function of this protein?
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
What are the official names of this protein?
GATOR complex protein WDR59.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR59 family.
What are the subcellular locations of this protein?
Lysosome membrane.
Protein: OTOAN_MOUSE
Sequence: MSQGPRTCSLLLVLLLSHGGAYQREPSPRQDLHPLLQKMAEEIIEGSYLNALLDLTLFERSHVWTADLSHRVLAYLNSKNVAFTIPSLQAVMEAHLEQYLYQPQKLLEDLRATDNQQFHTAMKCLLEDKWGHLDLEDVVINLGDIRDEALQSPGVNRSLFLITLERCFQVLNALECVEVLGRVLRGSSGSFLQPDITERLPQDLHEDAFKNLSAVFKDLYDQTSAHTQRALYSWMTGILRTPFNVTDGSVSWVSAEKLWILGRYMVHLSFEEIMNISPIEIGLFISYDNATKQLDMVYDITPELAQAFLERIRCSSFDVRNISTIHRLGLLVCFYDGLELLDATLAQVLLHQMLKCSRLRGFQAGVQKLKANLLDIATENQTLNETLGSLSDAVVGLTSSQLESLSSDAVHSAISTLNQVTGWGRSQIVILSAKYLAQEKVLSFYNVCQMGVLLAGVGTQAFYSMDHKDLWQVLRSPLSQDMSDLSPVQQQGVLGKLMEAEDATSGIAEVPRALFKEVSLYDLWKESRFNATVLKAKELRRSQALFLYEFLGKTTERPEELLSAGQLVKGVPCSHIDAMSDHLFLALFQYFDNNFSLLSPDQVNCLAWKYWEVSRSSMPPFLLATLPSRFLSSIPPSRCVRFLISLGKRRLETLVLDSDKRSVVVRKVQQCLDGVIADEYTVDIVGHLLCHLPASFIERGISPRAWAAALHGLRSCTALSSEQKAAVRVRLLEQWGPPENWTAETTKDLAPFLAFFSGDELHTVATKFPEILQQTASKMVGVLLPKEFLWAVFESVQNSSNESPSFDPTFGCHGVVTPSSDDIFKLAEANACWDPEVLLCMEEDTFIRNVELLGAVKGFSRAQLMALKEKAIQVWDLPSRWKEHHIVSLGRIALALSESELEQLDLSSIDTVASLGQQTEWTPGQAKSILQAFLEDSGYGIQDLKSFHLVGFGPTLCAMDPTEIQLIKTSEFRAVVARIGTLFCSTPVLAGFKKKAEVVFGRPTEWTSSILQELGTIAAGITKAELRMLNKELMTYFQPSAIRCLPGEVFKELSTEQIASLGPQNAASVTHSQRLQLSSAQLQSLQRALDGAKTHSWQTDPLSSSPTWPASTGSPTGEPASQALWLGCTLLLLTAKS
What is the function of this protein?
May act as an adhesion molecule.
What are the official names of this protein?
Otoancorin.
What is the protein family that this protein belongs to?
Belongs to the stereocilin family.
What are the subcellular locations of this protein?
Apical cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Note=At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes.
Protein: CAGE1_HUMAN
Sequence: MNKDYQKFWSSPSDPVHFEVDTSHEKVESMSESDTMNVSNLSQGVMLSHSPICMETTGTTCDLPQNEIKNFERENEYESTLCEDAYGTLDNLLNDNNIENYSTNALIQPVDTISISSLRQFETVCKFHWVEAFDDEMTEKPEFQSQVYNYAKDNNIKQDSFKEENPMETSVSANTDQLGNEYFRQPPPRSPPLIHCSGEMLKFTEKSLAKSIAKESALNPSQPPSFLCKTAVPSKEIQNYGEIPEMSVSYEKEVTAEGVERPEIVSTWSSAGISWRSEACRENCEMPDWEQSAESLQPVQEDMALNEVLQKLKHTNRKQEVRIQELQCSNLYLEKRVKELQMKITKQQVFIDVINKLKENVEELIEDKYKIILEKNDTKKTLQNLEEVLANTQKHLQESRNDKEMLQLQFKKIKANYVCLQERYMTEMQQKNKSVSQYLEMDKTLSKKEEEVERLQQLKKELEKATASALDLLKREKEAQEQEFLSLQEEFQKLEKENLEERQKLKSRLEKLLTQVRNLQFMSENERTKNIKLQQQINEVKNENAKLKQQVARSEEQNYVPKFETAQLKDQLEEVLKSDITKDTKTTHSNLLPDCSPCEERLNPADIKRASQLASKMHSLLALMVGLLTCQDIINSDAEHFKESEKVSDIMLQKLKSLHLKKKTLDKEVIDCDSDEAKSIRDVPTLLGAKLDKYHSLNEELDFLVTSYEEIIECADQRLAISHSQIAHLEERNKHLEDLIRKPREKARKPRSKSLENHPKSMTMMPALFKENRNDLD
What are the official names of this protein?
Cancer-associated gene 1 protein, CAGE-1, Cancer/testis antigen 3, CT3.
Protein: IF1_BACFR
Sequence: MAKQSAIEQDGVIVEALSNAMFRVELENGHEITAHISGKMRMHYIKILPGDKVRVEMSPYDLSKGRIVFRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y232_AGRFC
Sequence: MYKFEIYQDKAGEYRFRFKASNGETMFSSEGYKAKASAIHAIESIKRNSAGADTVDLTTMTA
What are the official names of this protein?
UPF0339 protein Atu0232.
What is the protein family that this protein belongs to?
Belongs to the UPF0339 family.
Protein: SECA_ELUMP
Sequence: MITTVIEKIFGTKSERDLKKLKPIIEKINSLESEILKLSDEELKQKTFYFKEQLAQGKTLDDILPESFAVVREAARRVIGLRHYDVQLLGGMVLHQGKIAEMRTGEGKTLVATLPSYLNALTGKGVHVVTVNDYLAKRDRNWMGPIHEFLGLSVGYINREMDNEGRQEMYKKDITYVTNNELGFDYLRDNMVVRKEDRVLKKLNYCIVDEVDSILIDEARTPLIISGPAEQSTDKYEVVNRIIPSLKIRKITEDDEIKAKYSGENLSAGYDAVIDEKNHNATLTEDGIAKAEKFLGVANLYNDVESEWVHHINQALRAHHLYEKDVDYVVKDGEVIIVDEFTGRLMPGRRWSDGLHQAVEAKERIKIKEENQTLATITFQNFFKLYSKLSGMTGTAMTEAGEFWQIYKLDVVEVPPNRPSKRVDGADLVYRTEREKYNAIVADIETLWKKGAPVLVGTRSIEKSEKVSAMLRSKGIPHKVLNAKYHEMEAQIISQAGAKGSVTIATNMAGRGTDIVLGGNPATPQQQAEVVELGGLHILGTERHESRRIDNQLRGRAARQGDPGSSRFYISLDDELMRLFANTSRISGILERMGMTEGQVIESRLMSRQIEGAQRMVEGHNFDIRKHLLDYDKVMNQQRTAIYHLRNKILDGESVSEQVMQMIEEVIHETFDKYYNVKHPQSTDFNTLNIFLQRAFTIDANFSGESIKGKSKEQIDGETFEAVKKAFEERSKYFNEQGVNFNEVERMLLLQIIDQAWKQHLYELDQMQKSVSLRGYAQKDPLIEYQKESYNLYQNMLNKVRDVMVEYIFRLQLPPKRRVSPIGTPSSEGGGETSGADTYSNKKIGRNDPCPCGSGKKYKKCCGADL
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: LSM12_BOVIN
Sequence: MAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEIINDRTETPPPLASLNVSKLASKARTEKEEKLSQAYAISAGVSLEGQQLFQTIHKTIKDCKWQEKNIVVMEEVVITPPYQVENCKGKEGSALSHVRKIVEKHFRDVESQKILQRSQAQQPQKEAALSS
What is the function of this protein?
Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein.  Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release.
What are the official names of this protein?
Protein LSM12.
What is the protein family that this protein belongs to?
Belongs to the LSM12 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Colocalizes with TPCN2.
Protein: TIG_BURVG
Sequence: MANVVENLGKLERRVTISLPKDTVQKEIDARIQKLAKNVRMPGFRPGKVPLKMVAQQYAGQVEAEVLSDKIGQEFFTISRAENLRVAGQPSFEPKQEQAEDAYAFDATFEVYPEVKIGDLATAEVERSTTSIGDAEIDRTLDILRKQRVHYHARGEAGEHGDGGADTAAKNGDRVTVDFVGKIDDVAFQGGTAEDFPFVLGEGRMLPEFETAALGLKVGEARTFDLKFPDDYHGKDVAGKTAQFTVTMKKIEWPHMPEIDAEFAKSLGIEDGDLTKMRAEIKENLEREAKRRTQSIVKNQVMDALLKISELDVPKALIEQDQQRLVEMARQDLAQRGVPNAKDAPIPAEMFAEQAERRVKLGLVLAELVKANGLEAKPEQIRAEVDEFAKSYEDPKEVVRWYYSNQQRLAEMEAFVVESNVVEFVLGKAKVTDKEVSFEALASASAQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: EXO84_CANGA
Sequence: MVDFSLRKTRNYWKGSNSSSKQNSEVSLKNAEKKKPVTNPYANLTVPNAANLPTLDAKERNKAASSMQRRLSIHTANYTAPNLDYSMPLPSSNLIDQAMGDEQPTGKVPAINVDDEYGQRNGHSRSATPTDNETSRRPETLRPPELNRKRLGGSGSSAPSGSSRMTMVAPLNPLSPYANLFHPASLRKILSDPQFSAKKFIHERLSEASAVDIDLFTSNLTELSTDVQEEVKRNIYKSYNEIITVNNDLHEASAELKQLRSSISELTKVTDQFVTVAKSRIQMDEQQKMLHTQRPSSPQKTQSSSLLPPVSSDINGTNPKRDRTSVMILEKMWDTQLATLYKNVEGAQKHLGPASNRHLLIESSDWTELNISTQKPLQTVQLYILNDAVLVAGKTKNKQHELIVSQCCPIRDVTISTDREYRTKLMFNFGNSNTCLYETRDINECMRVLDAFRKAKDDLRDITENEKENSKRIKESLVYLQNTQQTPGREGSKSPAKRRSMGLSPSSASRPLSASMDQFILQNLSISVHSRSKSHDWSSLSHKFKLVDNLIEEVDIDLARLKFDSAVNTLLEAESQLATMKDPTKEEDAIILNVLTLKLDQRRDDILTKVTQRNLFINEIAHLREGVKTLIRLGLPEAGLDLLLQNKSNLIQELLLQVGSSEHPSLYLTELAIVRFQIIKRTVIVFRELFHRDHDKLSSILVSWCSHEVEKHFNLVSKQLLNGDKLSPDAIRYSRKQIDDLKTVGLDFVYKLDEFIKNNINKLG
What is the function of this protein?
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis.  Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis.  Also involved in assembly of the spliceosome (By similarity).
What are the official names of this protein?
Exocyst complex component EXO84.
What is the protein family that this protein belongs to?
Belongs to the EXO84 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Note=Cell periphery. The polarization of EXO84 requires actin cables (By similarity).
Protein: MURA_COXBR
Sequence: MDKLIIVGGVPLNGSIRISGAKNAVLPILAATLLIEEPVILSNIPHLNDVTTMIELLGRMGAQITIDERMSIEVDCSQIQNVHASYELVKTMRASILVLGPLLSRFGKAEVSLPGGCAIGSRPVDVHIDGMRALGADIELVDGFIHATVEGRLKGAELNLGKITVTGTENLIMAATLAEGQTIIHNAACEPEVQDLANFLNKMGARISGAGTDTIVIDGVDRLSGGSYSILPDRIEAGTYLVAAAMTRGHVRIRDVFPKTLGAVLEKLHEAGARVKIGENWVDLDMQGRRAKAVDIVTAPYPEMPTDMQAQFMALNVVAEGQAVITETVFENRFMHVHELQRMGADIKLQGSKALIRGKEKLTGAPVMATDLRASAGLVLAGLMARGNTIVDRIYHIDRGYECIEEKLAQLGAEIRRVSSHVYAARYAAQKRWL
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.