PharMolix/UniProtQA huggingface dataset:
Protein: TRUB_STRPQ
Sequence: MINGIINLKKEAGMTSHDAVFKLRKLLQEKKIGHGGTLDPDVVGVLPIAVGKATRVIEYMTEAGKVYEGQVTLGYSTTTEDASGEVVARSSLPAVLTEELVDQTMTTFLGKITQTPPMYSAVKVNGRKLYEYARAGESVERPRREVTISLFERTSPLNFTEDGLCRFSFKVACGKGTYVRTLAVDLGRALGVESHMSFLQRSASAGLTLETAYTLGEIADMVSKQEMSFLLPIEYGVADLPKMVIDDTELTEISFGRRLSLPSQEPLLAAFHGEKVIAILEKRDQEYKPKKVLI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: MTS1_STRSA
Sequence: MRYIGSKKLLLPEIKKMVDKHTDGSEEVFLDLFAGTNVVANYFKQFYTVYSNDMLFFSYVNAKATIENNSKPSFSKLIQAGISSPMTYLQNLEVNDETIGYYEVAYSPTGEANYLSVHNAKKLDIIRSQIESWKNQNLLTEHEYYYLLSSLIEALPFISNTTGTYGAFLKHWDKRSLNDLELQDFTIFDNSKQNKAFNEDANELVQKIKADIVYIDTPYNSRQYASNYHLLENVARNEHPTLKGITKIFDWKNLKSDYATKGKALVAMRDLIQNINSTHIILSYNNEGIISEEDLTNILKEFSVDGIVDIKKIPYRKYQSKNVSKNKEIYELLFYIQRKPFSKNKTLNKPLNNVRVSSTKKYIKSPLNYIGGKYKLLNQILPLFPKNINTFVDIFSGGANVGINVKAKKYIFNDMNTRINEMFRYFQTQPPVKLVQQIEEKIDEWGLSKTNEDAFLAFRKHYNTNPNPLDLYVLSSFSYNYQFRFNNSMEFNNPFGRNRSHFSENMRNNLLNFVTKLQTLDATFTDNYFNEFDFSNLTSNDFIYLDPPYLITTGSYNDGKRGFSDWNNTSEMKLLNFMDYLNQHGIRFALSNVTEHKGKTNQLLKDWAYSRNLNVNYLDHNYNNSSHNSKSKGSQEVLITNYETKTFNLLNTK
What is the function of this protein?
An alpha subtype methylase that recognizes the double-stranded sequence 5'-GGATG-3' in one strand and 3'-CATCC-5' in the other, methylates A of both strands, and protects the DNA from cleavage by the StsI endonuclease.  The 2 domains of the protein participate in modification of the two strands.
What are the official names of this protein?
Modification methylase StsI, M.StsI, Adenine-specific methyltransferase StsI, Type II methyltransferase M.StsI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: TIM13_CAEEL
Sequence: MDQLLDVETLKKLSPEQQEQVISGVKQQAALANAQNLVTDISEKCTNKCITAPGSSLASGEKQCLQRCMDRFMESWNLVSQTLQKRLQEEMASSGGMGGGFGQGPSFS
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.  The tim-8-tim-13 complex mediates the import of some proteins while the predominant tim-9/tin-9. 1-tim-10/tin-10 70 kDa complex mediates the import of much more proteins (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim-13.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: RPO5_THEPD
Sequence: MPRKFDVLEHELVPKHVLLSKEEANRLLKAMGLKKSELPWIYSTDPVARALKAKPGDVIMIIRQSPTAGESVAFRLVMRG
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo5, DNA-directed RNA polymerase subunit H.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP169_BPPZA
Sequence: MSVQLNAFTFILERRGWRMVCYEQLTTNGTRILHFYLKDNPTFFATYSSQFLSDTKMIRRFASWSGQLLEGSNSVFWTNITPFEPIDEETAEDIKNLDKVVEGMNFTL
What are the official names of this protein?
Gene product 16.9, gp16.9, Protein p16.9.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus gp16.9 family.
Protein: AROC_HERA2
Sequence: MPGNSFGRLFRISTWGESHGVGLGVVIDGCPAGLELDLAAIQAQLDRRRVGQSRMTSARREPDEVEILSGMFEGRTTGTALAMLIRNTNARSSDYDAIKHLYRPGHADHSYDAKYGFRDYRGGGRSSARETAARVAAGAVARQILATMGISLVAYTLSLGHLKAQIIDENEIENNIMRCPDPAVAEQMIAYVDQARRDLDSLGGVVEVRARGVPAGLGEPVFDKLDALIGHAMFSIPAVKAVEIGSGIEAGNARGSQNNDPFIQRADGSIGTSSNHAGGILGGISSSEEIVVRLTAKPPASIAQEQTTVDQAGEPATIVVKGRHDPTVLPRLVPVAEAMLALVLVDCVLQQRAARL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RS7_BORPA
Sequence: MPRRREVPKREILPDPKFGSVELAKFMNVVMLDGKKAVAERIIYGALEQVQVKTGKDAIEVFNLAINNIKPIVEVKSRRVGGANYQVPVEVRPVRRLALAMRWLREAAKKRGEKSMDLRLAGELIDASEGRGAAMKKREDTHKMAEANKAFSHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: HYALP_MOUSE
Sequence: MGELRFKHLFWGSFVESGGTFQTVLIFLLIPCSLTVDYRAAPILSNTTFLWIWNVPTERCVGNVNDPIDLSFFSLIGSPRKTATGQPVTLFYVDRLGLYPHIDANQAEHYGGIPQRGDYQAHLRKAKTDIEHYIPDDKLGLAIIDWEEWRPTWLRNWKPKDNYRNKSIELVQSTNPGLSITEATQKAIQQFEEAGRKFMEGTLHLGKFLRPNQLWGYYLFPDCYNNKFQDPKYDGQCPAVEKKRNDNLKWLWKASTGLYPSVYLKKDLKSNRQATLYVRYRVVEAIRVSKVGNASDPVPIFVYIRLVFTDRTSEYLLEDDLVNTIGEIVALGTSGIIIWDAMSLAQRAAGCPILHKYMQTTLNPYIVNVTLAAKMCSQTLCNEKGMCSRRKESSDVYLHLNPSHFDIMLTETGKYEVLGNPRVGDLEYFSEHFKCSCFSRMTCKETSDVKNVQDVNVCVGDNVCIKAKVEPNPAFYLLPGKSLLFMTTLGHVLYHLPQDIFVFPRKTLVSTP
What is the function of this protein?
Involved in sperm-egg adhesion.  Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida.  The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation.  This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
What are the official names of this protein?
Hyaluronidase PH-20, Hyal-PH20, Hyaluronoglucosaminidase PH-20, Sperm adhesion molecule 1, Sperm surface protein PH-20.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 56 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: VKT3A_ACTEQ
Sequence: DANSFCQLPAVVGKCRGYFPRYYYNTEAGKCQQFIYGGCGGNRNNFETVEDCRATCHSH
What is the function of this protein?
Dual-function toxin that inhibits both the serine protease trypsin and voltage-gated potassium channels (Kv).
What are the official names of this protein?
PI-actitoxin-Aeq3a, PI-AITX-Aeq3a, Kunitz-type proteinase inhibitor AEPI-I.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: PRMA_BRUME
Sequence: MAQSRLFFSADKAEAERTYNILEQAFEDDGFPIAITEIDEDRQIFEVSVYVEDDAEEVAARVDALVGPGLFDTEELPDIDWVTHSLEGLKPVRAGHFFVHGSHDRDKIEPGDIAIEIDAGLAFGTGHHGTTAGCLELIEETVETEHPTNALDLGTGSAVLAIAIARLAPIPILATDIDPIAVTVAAENAAKNGVAEHIVTATAEGFGHPIFRSYSPFDLIVANILANPLIELAPSIKEHLAPGGSIILSGILDSQHDAVLAAYQTQGLTHQKTLHREGWVAIHLK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_AMOA5
Sequence: MAYTSKLIEEAINEISALPGIGKKTALRLVLFLLKSNPEQTERLATSLHKLRSQIQYCQKCHNISDTTLCSICANPHRDTGLICVVENIQDVIAIENTAQYKGIYHVLGGLISPVEGIGPEQLYIEHLVQRVQQEQPQEIIFALSTTIEGDTTTFYITKKLKEFPVKLSNIARGVAVGSELEYTDEMTLARSIKERILYH
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: YHEU_ECOUT
Sequence: MLIPWQDLSPETLENLIESFVLREGTDYGEHERTLEQKVSDVKRQLQCGEAVLVWSELHETVNIMPRSQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: IL2_MIRAN
Sequence: MCKMQLLSCIALSLVLVANSAPTTSSTKETQQQLEQLLLDLRLLLNGVNNYEDPKLSRMLTFKFYTPKKATELTHLQCLAEELKPLEEVLYLAQSKNFHLTDIKELMSNINVTLLKLKGSETRFKCEYDDETATITEFLNKWITFCQSIFSTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYW1_STRCO
Sequence: MTRVFSGVKPTGHLTLGNYLGAMRRWAAVDQHRSDALFCVVDLHALTVDHDPARVRRLSRQAASLLLAAGLDPELCTVFVQSHVDEHARLSYVLECVATDGEMRRMIQYKEKAARERVRGGSVRLSLLTYPVLMAADILAYGTDEVPVGEDQTQHVELARDLAVRFNQRYGHTFVVPRATSPAVAARVMNLQEPASKMGKSDDTGPGIVYLLDEPDVVRKKVMRAVTDSGRDVVYDPEERAGLANLLEILAACTDGEPAELAGGYDSYGALKKDTAEAVVEMLRPVRERHMELSADPGYVDGVLREGAEKARAMARPTVDDAYRAIGLLPPVNAAR
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase 1, Tryptophanyl-tRNA synthetase 1, TrpRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPRP_HUMAN
Sequence: MGRLASRPLLLALLSLALCRGRVVRVPTATLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSLGSSFVELASTWEVGFPAQLYQERLQRGEILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTVQVKVLADSLHVGPSARPPPSLSLREGEPFELRCTAASASPLHTHLALLWEVHRGPARRSVLALTHEGRFHPGLGYEQRYHSGDVRLDTVGSDAYRLSVSRALSADQGSYRCIVSEWIAEQGNWQEIQEKAVEVATVVIQPSVLRAAVPKNVSVAEGKELDLTCNITTDRADDVRPEVTWSFSRMPDSTLPGSRVLARLDRDSLVHSSPHVALSHVDARSYHLLVRDVSKENSGYYYCHVSLWAPGHNRSWHKVAEAVSSPAGVGVTWLEPDYQVYLNASKVPGFADDPTELACRVVDTKSGEANVRFTVSWYYRMNRRSDNVVTSELLAVMDGDWTLKYGERSKQRAQDGDFIFSKEHTDTFNFRIQRTTEEDRGNYYCVVSAWTKQRNNSWVKSKDVFSKPVNIFWALEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLIMAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPVRGSLWREAATSLSNPIEIDFQTSGPIFNASVHSDTPSVIRGDLIKLFCIITVEGAALDPDDMAFDVSWFAVHSFGLDKAPVLLSSLDRKGIVTTSRRDWKSDLSLERVSVLEFLLQVHGSEDQDFGNYYCSVTPWVKSPTGSWQKEAEIHSKPVFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSHWCCKKEVQETRRERRRLMSMEMD
What is the function of this protein?
Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant.  Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).  In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity).
What are the official names of this protein?
Prostaglandin F2 receptor negative regulator, CD9 partner 1, CD9P-1, Glu-Trp-Ile EWI motif-containing protein F, EWI-F, Prostaglandin F2-alpha receptor regulatory protein, Prostaglandin F2-alpha receptor-associated protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: PSMG1_XENLA
Sequence: MATFFGEVQSVFSRAVDEEEEDEDDDEEEEEDREIIAELERKREVRVTWNPELTAAIESSPGKRLPCSSVILSVGDNATGFVSSYILSSGSWEVAGSVTLWNERCRDCNVRKDFLPAPSSCTFYRSITDPTVLLCQCNCHVAEDQLFQWCEKVFGSLEKSSLKVTVLSTCPVSEYKTPESTYSLPVPFLKALRTSEYREEVPCPLLEQPNIVDGLPAAVLSHCQVLGIPAVFYQCYTDISKLDSVTIKAFRPLLSSGSLSRLAADSANIQETLRKTVKLNEIQSNLYI
What is the function of this protein?
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
What are the official names of this protein?
Proteasome assembly chaperone 1.
What is the protein family that this protein belongs to?
Belongs to the PSMG1 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: PPCS1_ARATH
Sequence: MSSISGLVEDEISSFFESSPPLKNKEEIVANLNQFIELNSSCQGGMRRIVCVTSGGTTVPLEQRCVRYIDNFSSGNRGAASTENFVKAGYAVIFLYRRGTCQPYCRYLPDDPFLECFEFPDAKNIQVHGSHSGAVKMAVMDQQAAVAEGRLLKLPFSTIYEYLQMLRLIATILKDVGPCSMFYLAAAVSDFYVPWLSMTEHKIESGSGPLDIRLAQVPKMLSILRSNWAPKAFCISFKLETDSKILLEKATKALQKYKVHAVVANELLTRKEEVVVVSSSGNVVVRRDSNKPESIVEDNLIRLLVDRHSTYIKESLT
What is the function of this protein?
Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5/pantothenate, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:12860978).  The catalytic activity is not CTP- but ATP-dependent (PubMed:12860978).
What are the official names of this protein?
Phosphopantothenate--cysteine ligase 1, AtCoaB, Phosphopantothenoylcysteine synthetase 1, PPC synthetase 1.
What is the protein family that this protein belongs to?
Belongs to the PPC synthetase family.
Protein: PTH_TREPS
Sequence: MGIQLIVFLGNPGAEYEETRHNAAWLLLTYLFPSIVLPWRCGCRGSIARIEGFEGSSEEVWLLKPLTYMNRSGKSVGAACAFLQTDAKQLLVVHDELELPFGVVSLKQGGGLGGHNGLRSIKEVLGTADFWRLRIGIGRPPSESVNIAQYVLSAFYPAEMAAFPKLGRATRDLLCQLVVTDQAATVTLLSAWRKKRLLSLCE
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_PSEPW
Sequence: MSGNTYGKLFTVTTAGESHGPALVAIVDGCPPGLEISLADLQHDLDRRKPGTSRHTTQRQEPDEVEILSGVFEGRTTGCSIGLLIRNTDQKSKDYSAIKDLFRPAHADYTYHHKYGIRDYRGGGRSSARETAMRVAAGAIAKKYLATQGIQVRGYMSQLGPIEIPFKTWDSVQDNAFFSPDPDKVPELEAYMDQLRRDQDSVGAKITVVAEGVMPGLGEPIFDRLDAELAHALMSINAVKGVEIGAGFASIAQRGTEHRDELTPEGFLSNNAGGILGGISSGQPIVAHLALKPTSSITVPGRSIDVDGNPVDVITKGRHDPCVGIRATPIAEAMMAIVLMDHLLRHRAQNAEVKVATPVLGQL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: MURG_DESPS
Sequence: MKETRRKRILLTGGGTGGHLFPAIAAAQQFCREYPGAEVLFVGTKRKMDAETLERYGFKGVAINSYGLKGKNMRELVKALLVLPISCLQALFILARFRPDLVLGVGGYVTGPVVAMAKLCRRPTLIHEQNSVPGLANRKLAKLVDRVCVSLPASASCFPADKVVFTGNPVRENLVALAAKAREVKEGVTLLVLGGSQGARSLNRLIVEAFVGVGSESLAGINLIHQTGTKDLAWVKQAYGDAGRDVWVEPFFKDMDAVYSQADILVSRAGATTLAELATLGKPVILVPYPFAADNHQQKNAEYYVQGGGALLFKESELTAPQLVEAVISIATNREQRERMEFNQRRLAPTDAAGKIVAVCRQLINRDEL
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FABZ_BACC4
Sequence: MLNIEQIKEIIPHRYPFLLVDKILEVDEGKRAVGIKNVSANEEFFNGHFPDYAVMPGVLIVEALAQVGAVAVLKKEENRGRLAFFAGIDNCRFKKQVRPGDQLRLEVEMTRVRGPIGKGKAIATVDGEVACEAEITFAIGDKKE
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EGR2_PIG
Sequence: MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGSPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSNVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGPSAGTTGPGASGGSEGPRLPGSSAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSSSVPAASTASCTGGAQPGGPLCSSNSSTIGGGSLGPCSSRTRTP
What is the function of this protein?
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.
What are the official names of this protein?
E3 SUMO-protein ligase EGR2, E3 SUMO-protein transferase ERG2, Early growth response protein 2, EGR-2.
What is the protein family that this protein belongs to?
Belongs to the EGR C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EMAL4_XENLA
Sequence: MDGFAGSLDDSVSAASTSDVQDRLSALELRVQQQEDEITVLKAALADVLRRLAISEDQVATVRKAVPSKGPATLREALSMSCITNGGAGTRKPSHASSVAKKDTLSSAAKSVKRSSTLEKSHNSWDASEESRNKLMRAASTSKLTSKVSKATDKHKDIVISPEGEYIKMFMRGRPITMFIPSDVENYDDVRTELPPEKLKLEWVFGYRGRDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCIAVHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVSLSTLQVIGLGTFERGVGCLAFSKADSGVHLSVIDDSNEHMLTVWDWQKKSKIAEIKTTNEVVLAVEFHPTDAGTIVTCGKSHIFFWTWSGNSLARKQGIFGKYEKPKFVQCLAFLANGDVLAGDSGGIMLIWSKTNVESTASKGAKVLGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKVIMWDHDLNPEREIEVPDQYGTIRAVAEGKGDQFLVGTSRNFILRGTFNDGFQVEVQGHTDELWGLATHPFKDLLLTCAQDKQVCLWNSVDHSLEWTRVLDEPGHCADFHPTGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSVDGALLAVGSHDNFIYLYNVSENGRKYSRYGKCTGHSSYITHLDWSPDNQYIMSNSGDYEILYWDIPSGCKLIRNRSECKDINWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIALADDFCKVHLFQYPCSKPKAPSHKYSAHSSHVTNVSFTHNDGHLISTGGKDMSIMQWRLIEKVSHSQNDNIAESSSAVNSPVVSEKVLQPDTPTTLPQAVNKATEVEQTPAESMAPPEDALELEAQQPQDLDDVQSGKSSPLPEEANGQEPSDEVIEEPANSQIVDAQDENQDDDDAPLS
What is the function of this protein?
Essential for the formation and stability of microtubules (MTs) (By similarity).  Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (By similarity).  Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (By similarity).
What are the official names of this protein?
Echinoderm microtubule-associated protein-like 4, EMAP-4.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EMAP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center. Midbody. Note=Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis.
Protein: CASC3_DANRE
Sequence: MADRRRRRRRASQDSEEEDESASGSESGRSFSASRKTRGREPEPVESPAERVAAKSDDESECVSEDGVGEAVLSDYDSADLEENGSHTEGGEEEEEAEHFSEEEASRPAAESKPVADAPTEELVEGEERDESVKEVKADEKGNLAGERQSGDGQESTEDPENKGSKGQKLDDDEDRKNPAYIPRKGLFFEHDVRGQATEEERPKGRNRKLWKDEGRWEHDKFREEEQAPKSRDELIAFYGYDIRNGTGPSDGRSYRSRKPRHAGSPSREPRRYREGDKSVRSSWQGPPPGHRNAPQSVTVQSGQPLAPLSAPKPSGRPSTQPPQRSFQGSRAPSAPHRTEGRGPSKPSLDGAPLRGPRSQPVEGERGPRLRGRSSHAVHADRSPSLVVEDICSEEEEEEGEIPTATTTYTAHHYKTEKERVPSPRKQDSGMVMEGGSAAGQVRELSPPQERQVEKKSYSRARRATRTRPSDLSKQASLDDSSSAVQQAPVAAKSESWQEQSEAGTQSGLTGLDQDLARLSLTGQNWAQNPPSYLQAEMRGIRGSMHMAGGPPQYGNMEDMGVGGGRAKRYSSQRQRPVPEPAPMHIGVMEGHYYEPMTFQGPIYTHGESPAALPPQGMLVQPEMHLPHPTHPGLHPHQSGGPLPNPAIYAAPPVSLSPGQPPPQQLLPPPFYPPPGVMTFGNTNYPYPAGGTLPPMYPNPQAQSQVYGGVTYYDTIQQQAQPKRSPPRRSSNPVTVRPPPPEDQSRKAAEEIRS
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome.  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions.
What are the official names of this protein?
Protein CASC3, Cancer susceptibility candidate gene 3 protein homolog, Metastatic lymph node protein 51 homolog, DrMLN51, Protein MLN 51 homolog.
What is the protein family that this protein belongs to?
Belongs to the CASC3 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Cytoplasm, Stress granule. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cell projection, dendrite. Note=Shuttles between the nucleus and the cytoplasm in a xpo1/crm1-dependent manner. Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (By similarity). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (By similarity).