PharMolix/UniProtQA huggingface dataset:
Protein: CTK1_YEAST
Sequence: MSYNNGNTYSKSYSRNNKRPLFGKRSPNPQSLARPPPPKRIRTDSGYQSNMDNISSHRVNSNDQPGHTKSRGNNNLSRYNDTSFQTSSRYQGSRYNNNNTSYENRPKSIKRDETKAEFLSHLPKGPKSVEKSRYNNSSNTSNDIKNGYHASKYYNHKGQEGRSVIAKKVPVSVLTQQRSTSVYLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVESQKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLARKMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFKEEPKPEPLVLDGLVSCHEYEVKLARKQKRPNILSTNTNNKGNGNSNNNNNNNNDDDDK
What is the function of this protein?
Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit.  CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated.  CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats.  Involved in RNA polymerase II transcriptional elongation, and through PTI1, pre-mRNA 3'-end processing.  Participates in both positive and negative regulation of CTD phosphorylation.  Required for DNA damage induced transcription, including the expression of the RNR genes, and reprogramming of gene expression upon amino acid starvation.  Required for SET2 mediated H3K36 methylation.  Also regulates H3K4 methylation.  Controls the maintenance of suppressive chromatin in the coding regions of genes by both promoting H3K36 methylation, which leads to histone deacetylation, and catalyzing phosphorylation of the CTD required to localize H3K4 chromatin modification specifically to the 5' ends of genes, thereby creating a boundary for H3K4 methylation that prevents a mark associated with transcriptional initiation from spreading into the bodies of genes.  Involved in RNA polymerase I transcription.  Involved in telomere maintenance.  Acts together with SNF1 to induce GSY2 transcription in response to glucose limitation.  Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose.  Required for the integrity of the rDNA locus.  Functions in translation elongation by enhancing decoding fidelity.  Needed for translational accuracy by phosphorylating RPS2.
What are the official names of this protein?
CTD kinase subunit alpha, CTDK-I subunit alpha, CTD kinase 58 kDa subunit, CTD kinase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm.
Protein: TRMD_THEM4
Sequence: MRISILTIFPEMVEIVKKYGVISRAIKNGILEIEIFNLRDFTNDKHKTVDDYPFGGGPGMVMKPEPFFNFFEYYKERYGNTYTILTSPQGDRLTNHLVKELSEKESILIICGRYEGIDERVTKFVDREISIGDYVLTGGELPAMVIVDAVSRFIPDVIDKKSVEQETFNTGLLDHPHYTRPRNYKGLEVPEVLLSGDHKKIEIWRRKMALKKTMLKRPDLFLNKDLDGVDKVALLDLFRELINNAK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_EXIS2
Sequence: MRDHVAGRYAKALFDLALEHHVLDQAEADVRTLGEVLHATPELASVLENPSISAEELKQVLQTSFTGFNTIVLNTILVMVENDRASEVLSLPEHFIALLNEHRNVATAIVTSAYKLSDEELTNVKETFGQKSGKTLEVENVVDTNVIGGLRVQIGYTTYDGTIETKLTRLERELLKA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YCX9_CHLVU
Sequence: MNKKESILREFALLCYFFIVYLLLPKNAKHPLADKSFLDPHPVARVSPFGSRPPFLLMVPSTSVPNASLESGQSSTISPRRQKESSIPVLQASGSVSANKTFQSTESSALHQPKSSSSERTGKIITRQRPHSGPTSPRVTPGELLPTLEALKLQEALDFAQLKLKTRQVRYTINLRSQKLLDTICELNDEKRAEVEEQAAYIFTLQKELVETGYEKVSSYNFTYSRLKQKAEELKYASKKEVAQLVNSL
What are the official names of this protein?
Uncharacterized 27.9 kDa protein in trnR-minE intergenic region, ORF249.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MOBA_THESM
Sequence: MIGVVLAGGKSSRFGGEKLLYKINGKPLILHTIERVLNAKKIEEIVIVTSKEKMKSFEKLGFSVVVDKLKIGPIGGVYTAISHFADVFVVAGDMPLINPKFVDWIVEKFHESNTLVCVPKWKNGYLEPLHAAYSQDFLEMIKRQIEKGEYMLGKAIRASSPCYIKIESLPLEWQESLFNINAKSDLKKIKGALQV
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Probable molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_ECO45
Sequence: MKAKELREKSVEELNTELLNLLREQFNLRMQAASGQLQQSHLLKQVRRDVARVKTLLNEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: RL22_RICAH
Sequence: MVQENKNFATAKAKSVRVSPRKLNLVAAFIRNMKVSEALVQLTFSSKRIAKVVKGCLQSAVANAENNLGLDIDRLVITKATVGKALVMKRVMPRAKGRATRINKFFSNLYITVTEKEDN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CHEB_ECOUT
Sequence: MSKIRVLSVDDSALMRQIMTEIINSHSDMEMVATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRLRPMPVVMVSSLTGKGSEVTLRALELGAIDFVTKPQLGIREGMLAYSEMIAEKVRTAAKASLAAHKPLSVPTTLKAGPLLSSEKLIAIGASTGGTEAIRHVLQPLPLSSPALLITQHMPPGFTRSFADRLNKLCQIGVKEAEDGERVLPGHAYIAPGDRHMELARSGANYQIKIHDGPAVNRHRPSVDVLFHSVAKQAGRNAVGVILTGMGNDGAAGMLAMRQAGAWTLAQNEASCVVFGMPREAINMGGVCEVVDLSQVSQQMLAKISAGQAIRI
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPT45_MOUSE
Sequence: MTSMNKGNEEKTQGANRKQLLEELNEKRESYCLVERSNEVNLLRVQKRHFSKAYQTLACMHIKESVPESTRTSWVKHDLSVHKEKRHFLPKNNAIFG
What are the official names of this protein?
Spermatogenesis-associated protein 45.
What is the protein family that this protein belongs to?
Belongs to the SPATA45 family.
Protein: LEXA_BURL3
Sequence: MTKLTARQQQVFDLIRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAAGASRGIRLLGIDDAPHQFTLPHAGLMQLSLPLVGRVAAGSPILAQEHISQHYACDPALFTSKPDYLLKVRGLSMRDAGILDGDLLAVQKRTEAKDGQIIVARLGDDVTVKRLMRRPGGLELIAENPDYENIFVKAGSAEFALEGIAVGLIRSGEL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RS12_ECOL5
Sequence: MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVRDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: YLW3_CAEEL
Sequence: MAHNNYLDLEMLFNECNAQHYENLGMFFKWLQQFAAHHEDPKITIKDFKGDKTSGEMILHVNTFTLFKYRQEFDMKVSALNDNGLGWKILFVDRSLGCN
What are the official names of this protein?
Uncharacterized protein F22B7.3.
Protein: RL15_PSEA7
Sequence: MQLNDLRSAPGARREKHRPGRGIGSGLGKTGGRGHKGLTSRSGGKVAPGFEGGQQPLHRRLPKFGFVSLKAMDRAEVRTSELAKVEGDVVSLQTLKDANLINQHVQRVKVMLSGEVGRAVTLKGIAATKGARAAIEAAGGKFED
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: MASP1_AGEPP
Sequence: INWLKLGKAIIDAL
What is the function of this protein?
Antibacterial peptide (PubMed:30974767).  Inhibits biofilm formation of A. baumannii and Staphylococcus spp.  bacteria (PubMed:30974767).  Also shows potent mast cell degranulation activity and potent hemolytic activity of rat erythrocytes (PubMed:15052574, PubMed:15225564).  Does not show chemotaxis for polymorphonucleated leukocytes (PMNL) (PubMed:15052574, PubMed:15225564).
What are the official names of this protein?
Agelaia-MPI, Agelaia-MP.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Mastoparan subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NUDI_SHIFL
Sequence: MRQRTIVCPLIQNDGAYLLCKMADDRGVFPGQWALSGGGVESGERIEEALRREIREELGEQLLLTEITPWTFSDDIRTKTYADGRKEEIYMIYLIFDCVSANREVKINEEFQDYAWVKPEDLVHYDLNVATRKTLRLKGLL
What is the function of this protein?
Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
What are the official names of this protein?
Nucleoside triphosphatase NudI, Nucleotide diphosphatase NudI, Pyrimidine deoxynucleoside triphosphate diphosphatase, dCTP diphosphatase, dTTP diphosphatase, dUTP diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudI subfamily.
Protein: MUKB_SALG2
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLSLAELKDKLDEMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRLTLEAIRVTQSDRDLFKHLISEATDYVAADYMRHANERRVHLDQALAFRRELYTSRKQLAAEQYKHVDMARELGEHNGAEGSLEADYQAASDHLNLVQTALRQQEKIERYEADLEELQIRLEEQNEVVAEAAEMQDENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAISALARAKELCHLPDLTPESAAEWLDTFQAKEQEATEKLLSLEQKMSVAQTAHSQFEQAYQLVAAINGPLARSEAWDVARELLRDGVNQRHLAEQVQPLRMRLSELEQRLREQQEAERLLAEFCKRQGKNFDIDELEALHQELEARIASLSESVSSASEQRMALRQEQEQLQSRIQHLMQRAPVWLAAQNSLNQLSEQCGEEFTSSQEVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGAEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQIAEQLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPSLPIFGRAARENRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLSVAFEDDPEAEIRRLNGRRVELERALATHESDNQQQRLQFEQAKEGVSALNRLLPRLNLLADETLADRVDEIQERLDEAQEAARFVQQYGNQLAKLEPVVSVLQSDPEQFEQLKEDYAWSQQMQRDARQQAFALAEVVERRAHFSYSDSAEMLSGNSDLNEKLRQRLEQAEAERTRAREALRSHAAQLSQYSQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARQRRDELHAQLSNNRSRRNQLEKALTFCEAEMENLTRKLRKLERDYHEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADELRSMSDKALGALRLAVADNEHLRDVLRLSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQSVSFGQVNSVRLNVNVRETHATLLDVLSEQQEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVIVVQSWEDEARRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGTQTEDTPSEAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: RFAH_ECO57
Sequence: MQSWYLLYCKRGQLQRAQEHLERQAVNCLAPMITLEKIVRGKRTAVSEPLFPNYLFVEFDPEVIHTTTINATRGVSHFVRFGASPAIVPSAVIHQLSVYKPKDIVDPATPYPGDKVIITEGAFEGFQAIFTEPDGEARSMLLLNLINKEIKHSVKNTEFRKL
What is the function of this protein?
Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.  RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons.  Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites.  Termination signals are bypassed, which allows complete synthesis of long RNA chains.
What are the official names of this protein?
Transcription antitermination protein RfaH.
What is the protein family that this protein belongs to?
Belongs to the RfaH family.
Protein: SYW_OCEIH
Sequence: MKTIFSGIQPSGTLTLGNYLGAIQQFVELQNDYNCYFCIVDEHAITVPQDRLELRKNIKSLAALYIASGIDPDSSTLFIQSEVPEHTQLGWMLQSISYVGELERMTQYKDKSQGQEAISSALLTYPSLMAADILLYNTDVVPVGDDQKQHLELARNLAQRFNNRFNDIFTVPEVRIPKVGARIMSLQEPTKKMSKSDTNQKGFISMLDEPKRIEKKIKSAVTDSEGIVKFDKENKPGVSNLLTIYSSCTGESIADLEKKYDGKGYGDFKQGVANAVIDTLRPIQEKYEQLIQSDELDAILDQGRDKASFSAGKTIKKAKKAMGLGRK
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC_RICCO
Sequence: ASFBZAPPGBVKAGEKIFKTKCAQCHTVEKGAGHKQGPNLNGLFGRQSGTTAGYSYSAANKNMAVQWGENTLYDYLLNPKKYIPGTKMVFPGLKKPQDRADLIAYLKZATA
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: ERA_BUCAP
Sequence: MKKRKQYCGYIAIVGKPNVGKSTLINEIIENEISITSKKKNTTQKNILGIKTKQLHQFIYVDTPGIYLNNEKDDSFKIIKSSILILFIVDRTVWKTDDEIVLNKIKKNKIPIICVINKIDKILDKSIILPHINFLLKKINPIEIIPISAKKRENIVLLENLIYPYLPNNNHIFPKKYITTHSLSFSISEIIRQKLIFFLRDELPSIITVKIESIEEKFKKKLYIRAAIYVKHERQKKIIIGKKAEGIKKISIASRLDIEKKINMKIYLIIWVKVKIKK
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: VDR_HUMAN
Sequence: MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
What is the function of this protein?
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179).  Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609).  The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609).  Plays a central role in calcium homeostasis (By similarity).  Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638).
What are the official names of this protein?
Vitamin D3 receptor, VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Translocated into the nucleus via both ligand- dependent and ligand-independent pathways; ligand-independent nuclear translocation is mediated by IPO4 (PubMed:16207705).
Protein: MTR3_SCHPO
Sequence: MSDRKRVYGPSVSVPPYFEEPEQPVFTRTRDVDRCRKIYLKLGWATKAVGSSYFESEKIKIACTVSGPRPSKTFAFRSSAKLNCEFRLSPFSTSVRQGHVQTVEEKSYSQMIEAAISPSILLHLYPKSSIDVYIQVIESDGALATLAAAISCASSAIADANIDCIDLVTGSSVLFNPNTDEYWIDPDYVDERARAAKGSVVMGYMASLGHVTQVWERGTCSPSRLSFLTEKCIKNAKDTRLVINHALLLEKSKSEDP
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation (By similarity).
What are the official names of this protein?
Exosome complex component mtr3.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: HINT3_RAT
Sequence: MAEKQAGLAGEPNPDCTVTAKAGPEVSSPGTSESRDYDSNCVFCRVAAGQEPETELLYCENKDLVCFKDIKPAALHHYLVVPKKHIGSCKDLNKDHIEMVESMVTVGKTILERNNFTDFTDVRMGFHVPPFCSVSHLHLHVIAPAKEFGFLSRVVYRRDSYWFITGDYLLEKLRK
What is the function of this protein?
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity).  Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (By similarity).
What are the official names of this protein?
Adenosine 5'-monophosphoramidase HINT3, HINT-4, Histidine triad nucleotide-binding protein 3, HINT-3.
What is the protein family that this protein belongs to?
Belongs to the HINT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: COMF_DICDI
Sequence: MKIYKKNHFLKILIIFIYLSCNILKVNADGTFSTIQPSTDIKFDKSNLEFVAEWDVSANSISNVVGSTDSSEFSLNYGVWGPTYNYLIAKNKSPSIKANVDYTFSFDFKLGKALGEYNNYQSMVLSFYIPEDIAYFPWEIRTPLYTTNEFSGNFASTSYQSKILTFRSTVDIGNSIMVLRINRATETGPTASSVYFRNMKITIPSKPITTPTDLLTKDSELIVIPKPPISLDLQDLTKCPYLTASDLYNWHDPTIWPNGVVPSPNQNITIPAGKRVLISASSISQTQIYSRIVVPVNSELIFNDQNFTMNIRDIYVQGKFIMGTSLCRYNSFINIIFHGEKTLQDTIAQFYGSKGIAVASGGFISVQGKQYHNTWSKLASNVWSGDRVIWIQDNVNWEVGQQVLITTSVYKDELDNQNEILTIKAIEGKKIEFTEPIKWFKYGSQEYQSEVALLSRRIVFSSDESSSVSTSFGGHILSSGEMQFAGVQLKRMGQKNVKARYPLHYHLGGTLNNSFISDCSVTNSYYRCYTIHGTNNVTLTRNVAYDAFGHCYYLEDGVEVDNRISFNLGAYVHTIGKPAAGASQIGETFYQSSELTQPADSAASCFYITNSWNSFIGNAASGGWAGFAFPNLPKPIGNHRTLNIIPMQYPIKEWQGNTAHSSGYYFEDGASIYVGGNLTFNEANGMLIYNSGRLGRTTYVNGVKNENNVVFDRLNNTKIFLSNLGVGYWGENIEIVGYESHDNTRPVSLFGNVWLHNALVNGQSGNILTKNSETTRQGFRFYDFYVQTIISNTIFRNFIHSTAATKRDEDNVVITATTFSDVFKPQFISATKNITFQNVPQSQIIGHEDVANSGSSRLFNFLDGDGSVTSSFTGKPGIPQIVGSHVSWWKFDDSCLFSTEWNVWVCNKGTKGLANIEFWVPGFMERELEQDPDSYIGSISLFGSGINDERKTLLTRNPGITGVSNMGWYAYFTIGTPNYLRIWTAQIAFGEYIFLAIPYPTGTTFTITSEYDYSNQYTYTITKTTSALAVKQGNGKQYYFDGTHLFLKLVNFMNTGGSWESFDRVGIKIPDVYWTYIYNIRATNTAKPSVNGYFLNLPDVRPSSTL
What are the official names of this protein?
Communication mutant protein F.
What is the protein family that this protein belongs to?
Belongs to the comF family.
What are the subcellular locations of this protein?
Secreted.
Protein: POP6_YEAST
Sequence: MINGVYYNEISRDLDISSSTQCLRFLKETVIPSLANNGNNSTSIQYHGISKNDNIKKSVNKLDKQINMADRSLGLQQVVCIFSYGPHIQKMLSILEIFKKGYIKNNKKIYQWNKLTSFDIKREGRNELQEERLKVPILVTLVSDSEIIDLNLHSFTKQ
What is the function of this protein?
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.  Also a component of RNase MRP, which cleaves pre-rRNA sequences.
What are the official names of this protein?
Ribonucleases P/MRP protein subunit POP6, RNA-processing protein POP6, RNases P/MRP 18.2 kDa subunit.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUOB_CAUVN
Sequence: MEEGRPRMGVIVPGNSSPVPALSAGRSTVEGYDPKLHDPFFDGVSQQLADKGFITAAADDLITWARTGSLMWMTFGLACCAVEMMQASMPRYDLERYGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYYYSYSVVRGCDRVVPVDIYVPGCPPTAEALVYGVLQLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.