PharMolix/UniProtQA huggingface dataset:
Protein: TTC8_MOUSE
Sequence: MGSEMEPLLRAWSYFRRRKFQLCADLCTQMLEKSPYDQEPAPDLPVSQAAWILKARALTEMVYIDEIDVDQEGIAEMILDENAIAQVPRPGTSLKLPGTNQTGGPTQAVRPITQAGRPITGFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPKLAKALFEYILHHENDVKMALDLASLSTEYSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYIILDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNSSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEVALRFYRRLLQMGVYNCQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHIAVGIGDTNLAHQCFRLALVHNNHHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATVSDKIGDLQRSYVAAQKSEVAFPEHVDTQHLIKQLKQHFAML
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for proper BBSome complex assembly and its ciliary localization (By similarity).
What are the official names of this protein?
Tetratricopeptide repeat protein 8, TPR repeat protein 8, Bardet-Biedl syndrome 8 protein homolog.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium.
Protein: ENO_GRAFK
Sequence: MSAILDIHARQIFDSRGNPTVEVDVYTENGIMGRAAVPSGASTGEHEAVELRDGGKDFMGKGVQKAVDNVNGEIADHLLGFSVFEQNLIDQTMIDLDGTPNKSKLGANAILGVSLAVAKAAANELNMPLYRYVGGVSANTLPVPMMNIINGGSHSDAPIAFQEFMIMPVMADSFSHALKMGTEIFHNLKNVLHDRGLSTAVGDEGGFAPTLDGTEDALDTILKAIEKAGYKPGKEVMIALDCAAAEFFVDGKYDYTKFEGDKGKVRTSEEQADYLAELASKYPIISIEDGMDENDWEGWKAVTDKIGDKVQLVGDDLFVTNVERLGRGIKESIANSILIKVNQIGTLTETIAAVNMAHNAGYTSVMSHRSGETEDNTIADLAVALNTGQIKTGSASRSDRMAKYNQLLRIEEELGDVAFYPQDKAFKIK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: NU2C_LEOCS
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFHGSFIFPECILIFGLILLLMIDSTSDQKDRPWFYFISSTSLVMSITALLFRWKEEPIISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKRDVRSNEATTKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALISITVGIGFKLSPAPFHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFARIVSFGLRTGTDNIRDYAGLYTKDPFLALSSALCLLSLGGLPPLAGFFGKLHLFWCGWQAGLYFLVSIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIEWSMTVCVIASTIPGISMNPILAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic, NAD(P)H dehydrogenase, subunit 2, NADH-plastoquinone oxidoreductase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: IPO13_CHICK
Sequence: MERRAEAPPPPQGLDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWLLLNMDKVPEIQYSAPAPCTSRSPATGTTSLPDQYESLKSQLFTHITRFAGGSKIVLTRLCVALASLALSMMPEAWPCAVADMVRMFQAEDSNVDGRARCLALLELLTVLPEEFQTSRLPQYRKGQVRSVLAQECGSVFPLLEQLLQQQDSPGFIKQKVLKCFSSWVQLEIPLMDCENLIQAAFTSLQDPELFDTAVEAVVNAISQPDAQRYVNTLLKLIPPVLGLQEQLRQAVQSGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEPDKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSSLYDKLGRLLTNTEQPSTWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINNVLPLVLQALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQEVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLITPYIQQLEKLADETPNPSNKLAIIHILGLLSNLFTTLDISHHDDDHESTEVKKLPVQQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVESVCAIFEKSVKTLLDDFAPMVPQLCEMLGQMYSTIPQASAIDLTRQLVHIFAHEPAHFPPIKALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCSNLDVKALFHCGVLSLKFPEAPTVKASCGFFTELLPRCGEIAPVGQVVHENGKVLLQAVLEGVGGQASRSLMDHFAEILFALNKHCFSYLSIWIKEAMQQDGFPSARVSPEQKETFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTEYTADY
What is the function of this protein?
Functions in nuclear protein import as nuclear transport receptor.  Serves as receptor for nuclear localization signals (NLS) in cargo substrates.  Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
What are the official names of this protein?
Importin-13, Imp13.
What is the protein family that this protein belongs to?
Belongs to the importin beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ZHX3_RAT
Sequence: MASKRKSTTPCMIPVKTMVLPGASTEAQPVEPLPEGPQQDLPSEAPEASSEAAPNPSSTDGSALANGHRGTLDGYVYSCKECDFRSQDVTHFVGHMTSEHTDFNKDPHFVCTGCSFLAKTPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSVPENASSSVLAGESTEGTEIIITKTPIMKIMKGKAEAKKIHMLKENAPTQPGGEALPKPLAGETEGKEGDHTFINGATPVSQASANSTKPPHTANGPLIGTVPVLPAGIAQFLSLQQPTVHPQHHPHQPLPTSKALPKVMIPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLVASAGNVQHLIQAALPGHAVGQPEGTAGGLLVTQPLMANGLQASSSSLPLTTASVPKPTAAPINTVCSNTTSAVKVVNAAQSLLTACPSITSQAFLDANIYKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLKGTRAMVPGEHGSVLIDSVPEVPFPLSSKVPEVPCVPTATSLVSHPATKRQSWHQTPDFTPTKYKERAPEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKRVNAEETKKADGHAPQEEAEGAEEEGRDEELASELRAPGENGSSEMFLSHTLAERKVSPIKINLKNLRVTEASGKSELPGMGMGVCEPEEDGLNKAVEQPPSRVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLLVIAPGNRELLQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWFAEKMGEETRAVADTSSEDQGPGHGEPVAVDKVLGDACAALSENSEAWEPSAPEAGSEPFDTSSPQSGRQLETD
What is the function of this protein?
Acts as a transcriptional repressor.  Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation.  Is a regulator of podocyte gene expression during primary glomerula disease.  Binds to promoter DNA.
What are the official names of this protein?
Zinc fingers and homeoboxes protein 3, Zinc finger and homeodomain protein 3.
What is the protein family that this protein belongs to?
Belongs to the ZHX family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DEF_HELPH
Sequence: MALLEIIHYPSKILRTISKEVVSFDAKLHQQLDDMHETMIASEGIGLAAIQVGLPLRMLIINLPREDGVQHKEDCLEIINPKFIETGGSMMYREGCLSVPGFYEEVERFEKVKIEYQNRFAEVKVLEASELLAVAIQHEIDHLNGVLFVDKLSILKRKKFEKELKELQKQQKHK
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RL19_STAA3
Sequence: MTNHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIKRRGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYLRSLRGKAARIQEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: LPXH_COXBR
Sequence: MRHTLFISDLHLEEKTPSITAHFLYFLKHQAPKADAIYILGDFFEAWIGDDNQTPFNRKIIESLQTLARTKPTYFMRGNRDFLIGQRFAAMTGVSLLEDPSVIQLYNKPVLLMHGDSLCTLDHKHQAYRRKIMKPWVQKLMLSLPLSLRRKLAKKFREQSRRHNRTLSYEIKDVTPEEVNRVMKEQNVELLIHGHTHRPAIHDLTINGNPTKRIVLGAWHHGGSVLRYAQDGSFELQAFKIDL
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TCAB1_MOUSE
Sequence: MKTSEERLLAPDSLPPDLAPAPVPQGSPAEKNTDFEPVPPPCGGDDQPQLATDPVASLVVSQELQQGDSVPLEVEFNTSSELSPGIEEQDVSEHASLPGEETNLPELESGEATEGVSEERAEVDEGDTFWTYSFSQVPRYLSGSWSEFSTRSENFLKGCKWAPDGSCILTNSADNVLRIYNLPPELYSEQEQVDYAEMVPVLRMVEGDTIYDYCWYSLMSSTQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTSRPGRDCEVRATFAKKQGQSGIISCIAFSPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARKDAELLCWDLRQPGHLLWSLSREVTTNQRIYFDLDPSGQFLVSGNTSGVVSVWDISGALSDDSKLEPVVTFLPQKDCTNGVSLHPTLPLLATASGQRVFPEPTNSGDEGELELELPLLSLCHAHPECQLQLWWCGGGPDPSSPVDDQDEKGQRRTEAVGMS
What is the function of this protein?
RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836).  Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:29804836).  Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (By similarity).  In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:29804836).  Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (By similarity).  In addition, also controls telomerase holoenzyme complex localization to Cajal body (By similarity).  During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (By similarity).  In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (By similarity).  Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (By similarity).  Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (By similarity).
What are the official names of this protein?
Telomerase Cajal body protein 1, WD repeat-containing protein 79, WD40 repeat-containing protein antisense to TP53 gene homolog.
What is the protein family that this protein belongs to?
Belongs to the TCAB1 family.
What are the subcellular locations of this protein?
Nucleus, Cajal body. Chromosome, telomere. Chromosome. Note=Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies. In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM.
Protein: RS20_PETMO
Sequence: MPNKKSAEKRVRQSEQRRQKNRGYQKRIKEISKEIDKKIHENAEREELMQLLSKSFKIIDTAKSHGAVHKNYAARKKSKLHLKVKKYLGEMAPESSPVNE
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: FPG_BRASO
Sequence: MPELPEVETVRRGLQPVMEGAKIVTAEARRGDLRFPFQPDFVKRLQGQTVRGLGRRAKYLLADLGSGDVLLMHLGMSGSFRVIKPEHEETPGEFHYPRGKDSVHDHVVFHMSSGADIVFNDPRRFGFMKIIGRGEIETEPHLKDLGPEPLGNEFDAAMLARACAGKKTSLKAALLDQRVVAGLGNIYVCEALFRAHLSPRRLAATLATRKGEPTDHAKRLVEAIHTVLNEAIRAGGSSLRDHRQTTGELGYFQHSFQVYDREGEPCRTDGCEGVVKRFVQNGRSTFWCPKCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: LPP_MYCMS
Sequence: MKKATKLLLSILPISSISFLSVVSCSTRNSNAKQPDKKPEKPNEKGPIIPKNPDNKKPTNNNNNSNNNSNSNNNKPGSTVPNENKDPSKSEETPEKPERDPKKPDKQPQGDDPNNHQPHNNQHADQPNINKDEFADLDKLPKEISFERFDFYTSKDATTALSHLRTDGSVIKIIFSNTHRNIFGKYNINLELDGNEKEDVKKGLIDKVKVKFTNKKDKKSKIIEFTFTGFKVIQKSPDKENKNSKKNYIKKKEKIDNKLTGLYPSLVAYMIMYTQEPKNYKNLMQKDSINFEELENNNPNLFADPEINLNVVALKDLLLEYNRELGKLYKDKVIAVSYDDVNGKLGLKLLIENREENDTIASKYSETLEFDFVGFRKIDLKNPNKNVLSLLFPQNNFKDMIKNNVFKKKIEVLKSGKQKEDMVLVKEEYAKQLIFKNLLVQIIDNENNLYRSTQTLSLQNNKKDNYTSILGLAGGGTLYPFHTIINNNSIKNIYLMINKEKNKKYKVAINFEVDIPIFASTTSDLTFHATSGDTNILKLDITTNALID
What are the official names of this protein?
Uncharacterized lipoprotein lpp.
What is the protein family that this protein belongs to?
Belongs to the mycoplasma p72 lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: SLF2_MOUSE
Sequence: MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTAPAAAGKRTESPGDRKQSIIDFFKPAAKQDKHMLDSPQKSNIKYRGNGLSITGTEQFERKLSSPKKLKPKRMSSEESPILEAFMKGGKEHHKDRGVHESRRPCMSLSKYLPKGAGIYAPSSYRLPKEIKAQKKKHQSPERRKSLFIHESNREKNDRDRGKNSEDSRKQATATEGDIFKHSSRSISSRSSLSRHHPGESTLGARFQLSLASYWREREQKKLRKEQMEQRINSENSFSEASNLSLKSSGVGKNCKPRHEHSKHTEAVPGKSNLSTLENGHLSRKRSSSDSWELSGSKQNKFSDKRTEELCGLRPEKHKRTYHTKSKRVLSREAPRHIPSERKVYQTHCTEDSWWCSALGRHSQGAGKTVSRGMSIASTLRLYLGRVISQLWKMDISQEKDHLQTRGNFQALNRINSPTKEQRNSVDSDLKSTKEPIIPKARESFLEKRPDTSHQREKFIRHIALKTPGGVLRLEDIAKEPEDETDRSSADSAPSNAGHHSSRNSDQVHSASTKETKIQKPHLPLPQEKSTIKRASNLQKNKPAGSVTSKETKLPLLSHVPSAVSSRVPLNAKNCTLPVPKKDKERSSSKERSGHSTESSKHKEHRAKTIKAVSNESSGKNSGGSLHSEYAPPTASPPAALEVVPSVPSPAAPSDKESSGNSNAGSNALKRKFRGDFDSDEESLGYTLESDEEEETLKSLEEIMALNFSRTPTTSGKPPAVSKGLRSQSSDMKEYAQSGTYTNTLERLVKEMEDTQRLDELQKKLQEDIRQGRGIKSPLRTGDQDSTDDGDGLLEEHREFLKKFSVTVDAIPDHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGESAVEKLILKSGKTDQIFLTTQGFLTTAYHYVQCPVPVLKWLFRMMSVHTDCIVSVQILSTLMEITIRNDTFSDSPVWPWIPSLSDIAAVFFNMGVGFGSLFPLETLQPDFNEENLISETQKTLGGKESEDSPYSPVFSALPETNILNVVKFLGLCTSIHPEGYQDGELMLLILMLFKMSLEKELKQIPLVDFQSLLINLMKNIRDWNTKVHELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVMMSKLLDEKHEDIPNANNLQISVLHRYLVQMKPSDLLKKMVLKKRAEQPNETIDDSLHLELEKQAYYLTYILLHLVGEVSCSHSLSSGQRKHFVLLCGALEKHVKCDIREDARLFYRTKVKDLVARIHGKWQEIIQNCRPTQGQLHDFWVPDS
What is the function of this protein?
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance.  The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks.  Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions.
What are the official names of this protein?
SMC5-SMC6 complex localization factor protein 2.
What is the protein family that this protein belongs to?
Belongs to the FAM178 family.
What are the subcellular locations of this protein?
Nucleus. Note=Mainly localizes in the nucleus. Colocalizes with PCNA on replication sites. Associates with chromatin. Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin- dependent manner.
Protein: DLTA_BACC7
Sequence: MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSGTEVTVTDLPVRIVSEDNLKDIFFTHKGKTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTKWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTSTPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLNQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFMYQSSIPMTPNGKVDRKKLLSEVTA
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGT3_DROME
Sequence: MGDLLSNSEFFKKLGVDSSNQWILYDEQMEMFFKFLSGNITDANILTERQVLEREEMQRRGEWLSASDRELKLLQIEAESPGLLNYKQQDVDALTMSIEAIEDASRDYATLLEDMMTTKHSITKHLGEVECVTAELQLREKDLIAECQSKAKQLEELQQENCRLSAEAKKAFTAPQLPPLFMHQLPLEQYFHKCDSFMQYFTLYVKENFKIQDYDEFQSAEEDLGREKAKLEDLERGIQFYALSYIRTKAKVKATQCLIDQLDLGKIHCLSLTDMAREMHDLQLLNDYQLSNTHDTLLNDLTIHIQQHTQRRIELVLYENTKLKLERAVRRHESDKKLTKIISDALSNAELLWIAIQLDCDKKRNCLDTSEELRDQAQATWQRIQTMRSINASYQGICAQFVQEIANLLSAHLGQNIKATEAKACLFEYEKFGRLLSYSFQSMLNRKSCAAVQDQLAELKRLEQTLRPFVYDSPLEQPMFENVRYLSAIYNVTQQQTRLDESGRSLRKDFLENVVGRIERDKLYRYSVVLWIWFLTEPQRMMHAIDEVKKAAAAVIRPGGGLHRK
What is the function of this protein?
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220).  The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918).
What are the official names of this protein?
Augmin complex subunit dgt3, Dim gamma-tubulin 3.
What is the protein family that this protein belongs to?
Belongs to the HAUS3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle.
Protein: CRCB_HELPH
Sequence: MNFVFLWAALGGAIGSSLRYFVGKVMPSKFLMFESFPLGTFSVNLIGCFVIGFMGHLAAKKVFGDDFGIFFVTGVLGGFTTFSSYGLDTLKLLQKSQYLEAVSYVLGTNLLGLIGVAIGWFLAKNFVGVN
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ZDH21_PONAB
Sequence: MGLRIHFVVDPHGWCCMGLIVFVWLYNIVLIPKIVLFPHYEEGHIPGILIIIFYGISIFCLVALVRASITDPGRLPENPKIPHGEREFWELCNKCNLMRPKRSHHCSRCGHCVRRMDHHCPWINNCVGEDNHWLFLQLCFYTELLTCYALMFSFCHYYYFLPLKKRNLDLFVFRHELAIMRLAAFMGITMLVGITGLFYTQLIGIITDTTSIEKMSNCCEDISRPRKPWQQTFSEVFGTRWKILWFIPFRQRQPLRVPYHFANHV
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity).  Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane.  This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).  Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation.  Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium.  Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction.  May also palmitoylate eNOS and LCK (By similarity).
What are the official names of this protein?
Palmitoyltransferase ZDHHC21, Zinc finger DHHC domain-containing protein 21.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: SYGA_SALEP
Sequence: MQKFDTRTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTCLRALGPEPMATAYVQPSRRPTDGRYGENPNRLQHYYQFQVVIKPSPDNIQELYLGSLKELGMDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLVWSDGPLGKTTYGDVFHQNEVEQSTYNFEYADVDFLFTCFEQYEKEAQQLLALENPLPLPAYERILKAAHSFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCNKDK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.