Protein: DTPA_ASPFN
Sequence: MSCENEAPLTRSFCRTKRRDRFSHEEAARKCRIETHDIEDIRACTQEQLVYATLLSQGDEGAIAEWSFDIPESINIDFLKKAWQDMVRSKAFLRTRIIADDSPGIFLCVVMNGEPLLWTEGDGMDDPWVLGSSLARFRLIEVPNTNQRRLVVKIHHAICDPCSLYAVFESVDHAYQKKKLYNLQQNETPTACTTEGSFDDATAFPELPASVQCPSARHSLEQSVSVGTLPPSLGEITANVWLAWAITQSQYQSSDRVLFGTGSRHDEERPGFPAYVSPRLVVLDSQVAVADILQELENMFIGPAQKRTAVRTPSAEKKGMSGAVQTVVSVRRLAQHRPLTCANLVKSEKQNPFQNYALTLDCQLEKDFLIKVQAHYDHNVIPQWVTQRVLSHFMHVLPQTFHRNRDTKLASLKSLSPYDEAQLAYWNSKHVPVAEEPTHHIIHRICMEQPNAEAICSWDGKFTYNEVDVLSDSLATQLTDLGLGGSGSIIPVYMDKGRWVPIAILGVLKSGAAFTLFDPSHPLQRLKIMAEDVKAKAILCSRMTMELASQIVPQTLQIDDERGWDTIRARPGSHFSRSSRQDDALYVAFTSGSTGKPKAIVIEHGSYCTGAKEHIKAFRLSRKARVLQFALYAFDVSIMEILSTLMAGGCICILNEVQRTTPQDFEKALSSFSVTHAFLTPSFARSLRNAQLPSLDVLILGGEPMSPADAGHWASRNVVLMNAYGPAECSVNTTVQPCAAACPGNIGFTTGAACWVVDPMNHNQLVPIGGIGELLVQGPIVGRGYLNNPTLTKASFVKFVPSISAHLPGAEIIDRAYRTGDLVRQQMDGSIVYIGRKDQQVKIRGQRIELSEVEFQVQKSLEGDVDVVIEAVDIEGKSQPLLVAFLNLGIHGAQANEDLAPLAMPCEEWFRRLESMEGALKHYLPPSMIPNLFLPLVYTPTTPTGKIDRRLLRELSSRLSQAQLELYRNRNKDELKRQPYTQVEETLQRLFSQILGVEQRHISVTDSFFQLGGDSISAIRLIGAARDAGLEFTVSELLSAPTISEVALYSRALSVPKEEASPPPPFVLLGTSAKVPEILQLVANQIKLSNLDNIEDIYPCTALQEGMFALSLKSPGTYTGEVLLRLPGDVDMQRLLSAWQATVEANPILRTQIVQTPKGLFQVVMRRVDFECKQHASLDALGKLHVNQDKGVSINPMCQVALVKHNGDQHFALKIHHALCDGWSLKLILGQLDLAYRKEASLTPSYFNTFIKYLDSIAGWEDYWTSEFRDLQAPIYPALPSPSYMPRPTSLRDHAIHNLHMADSGMRLPILIKLAWSILVSNYTDSDDVVIGLTLNGRNAPVPGIEQLIGPTITTVPLRTRIHEDDTVRTASNCLHNKLTAMISYEQAGLQRIGKLNDNCRTACSFQMQVGIQPPADFNTENYCFDVLEHSIGPSMDYSDFSTYGIVVVCELSRSGTALHVKMRHDPDLVSPDEANCMVHLFEHLLRQLCENPDMRLNQLELAGPQDIKQFAKWNATAPVPVERCLHELIMNHSRTQPGASAICGWDGYVTYQELGLLITQLAYYLRTRFHIRPGMNVPICPNRSKWAIVSMLSVLYAGGSCVLLDPNHPQARMQTVISDTAADIIICNAGTEEKVTGLTRHLVIVGPELLESLPTPASLPQCLSDATPMDPAFVIFTSGSTGKPKGIIMSHKSLSTSIYYHSPQLGVNQQTRTLHFCSYAFDASIYEIFTTLVCGGCVCVPSASDCTDNLAGFITHFDVNLAIMAPSVARLLHPDSVPSLQCLVLGGEALTWEIVNLWADRVRLVNGYGPAEATIMAAGVVQASDWITGLIGPVVGANPWITKPFNPDQLVARGMIGELLIEGPVLADGYINAPEKSADPFIPAPTWLRSIRPNSAGATRLYRTGDLVQQQRDGSIRFMGRRDNQVKLRGQRIELQEVEHCVTSHVPDAVVVAEVVSFLTNERRRNELVVFIRDSTAGTEPDNITSNPEETSAIFSSPTKVDHTAMAELKAHMARNLPRYMVPWIILPLDDIPKTASGKTDRARLRVAAGKLEQKTLDQYMNIANIVKRQPSTTQEALVRSIFAQVLSLPESTIGVDDSFFNIGGDSISAMRFLTLCRQANLHLAMPAFLTYNTVALFCTNASTSIDISRFDASEEMDRNTPLVTIDHEKHISTLRTTLCNQLGLDSVLSIEDIYPCSSSHAGIIRGLAGSGDRHQVRAIFKLHGSKVVDPAHVLECWHKLIQRHAILRTVIVNNPLHPGEFLHVVLKQPPIDMASLSFQSPNVVTQLCDIHPSFDWETSPAHQMVIAQGYEGEAYCKLEAGKALIDWSSFSILVDELCLAINHLLPSKPAPLYKDFISYVQRQPLDKIMNYWERTLSGVTSSIIPRSLPEAPADPDAVPVLHSTRITLDGFKDIDAFWRGNRLTLTNIFQVAWGLVLSFHSRLPEVCFGTVVSGRDIPVTNIEDMVGPCFNILPCRLDLSPDRNIMETLQQNQQDMQRRTDHQHCSISEITRGVRQTTSTPLFNTCLSVQVSLSSQMEEPSGDLGHDIQVSMVDIHDPTEYDICLAVLIYRTQIEIDLRYWSFAFSEQDATRLLNNLRQAISHIVAHSARPIASIDWEA
What is the function of this protein?
Nonribosomal peptide synthase; part of the gene cluster that mediates the biosynthesis of the dimeric diketopiperazine alkaloid ditryptophenaline (PubMed:24677498).  The nonribosomal peptide synthase dtpA accepts L-tryptophan and L-phenylalanine as its substrates and forms the phenylalanyl-tryptophanyl cyclic dipeptide product cyclophenylalanyltryptophenyl (PubMed:24677498).  The N-methyltransferase dtpB is responsible for the N-methylation of cyclophenylalanyltryptophenyl to yield cyclo-N-methylphenylalanyltryptophenyl (PubMed:24677498).  The cytochrome P450 monooxygenase is responsible not only for pyrroloindole ring formation but also for concurrent dimerization of N-methylphenylalanyltryptophanyl diketopiperazine monomers into a homodimeric product (PubMed:24677498).
What are the official names of this protein?
Nonribosomal peptide synthase dtpA, NRPS dtpA, Ditryptophenaline biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.