PharMolix/UniProtQA huggingface dataset:
Protein: CD40L_CANLF
Sequence: MIETYSQTAPRSVATGPPVSMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLYEDFVFMKTLQKCNKGEGSLSLLNCEEIKSQFEAFLKEIMLNNEMKKEENIAMQKGDQDPRIAAHVISEASSNPASVLRWAPKGYYTISSNLVSLENGKQLAVKRQGLYYVYAQVTFCSNRAASSQAPFVASLCLHSPSGTERVLLRAASSRGSSKPCGQQSIHLGGVFELHPGASVFVNVTDPSQVSHGTGFTSFGLLKL
What is the function of this protein?
Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
What are the official names of this protein?
CD40 ligand, CD40-L, Tumor necrosis factor ligand superfamily member 5.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cell surface. SUBCELLULAR LOCATION: [CD40 ligand, soluble form]: Secreted. Note=Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
Protein: SDHF2_YARLI
Sequence: MLRLVRSSRAFHTSLIRAGTQANINPVAGKTADEVDVKIEPIPRHGEETETKRARLLYQSRKRGILETDLLLSRYAKLYLKDMTREELEEYDKLLDEPDWDIFYWATRNDNIKPCPERWAKSPVMEKLRELAENKEREVLRMPDL
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 2, mitochondrial, SDH assembly factor 2, SDHAF2.
What is the protein family that this protein belongs to?
Belongs to the SDHAF2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RPOC_BRUME
Sequence: MNQEVMNLFNPQAPAQTFDSIRISIASPEKILSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKYKGIICEKCGVEVTLSRVRRERMGHIELAAPVAHIWFLKSLPSRIGTLLDMTLKDIERVLYFENYIVTEPGLTSLKEHQLLSEEEYMIAVDEFGEDQFTALIGAEAIYELLASMELEKIAADLRVDLAETTSDLKQKKLMKRLKIVENFLESGNRPEWMIMKIVPVIPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLIELRAPGIIIRNEKRMLQEAVDALFDNGRRGRVITGANKRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVTGPELKLHQCGLPKKMALELFKPFIYARLDAKGYSSTVKQAKKLVEKERPEVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPTLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLSLEAQLEARVLMMSTNNILHPANGAPIIVPSQDMVLGLYYLSIVAEKEPGEGMIFADMGELQHALENKVVTLHTKIKGRFKTVDAEGNPVSKIYDTTPGRMIMGELLPKNVNVPFDICNQEMTKKNISKMIDHVYRHCGQKETVIFCDRIMQLGFAHACRAGISFGKDDMVIPESKAKIVAETEALTTEYEQQYNDGLITQGEKYNKVVDAWGKATDKITEEMMARLKAVEFDPVTGRQKQMNSVYMMSHSGARGSVNQMRQLGGMRGLMAKPSGEIIETPIISNFKEGLTVNEYFNSTHGARKGLADTALKTANSGYLTRRLVDVAQDAIISEVDCGAEIGLTMQPIVDAGQIVASIGQRVLGRTALDPILHPVTGEVIVEAGRMVEEKDVEIIEKAGIQSIRIRSALTCETRNGVCAKCYGRDLARGTPVNQGEAVGVIAAQSIGEPGTQLTMRTFHLGGTAQVVDSSYLEASYEGTVKLRNRNVVRNSDGNLVVMGRNMAVLILDATGKERAVHRVTYGSRLFVDEGDTVKRGQRIAEWDPYTRPIMTEVEGYVEFEDLVDGLSVSETADESTGITKRVVIDWRSTPRGSDLKPAMVIKDKAGKILKLSKGGDARFLLSVESILSVEPGAHVKAGDVIARLPMESAKTKDITGGLPRVAELFEARRPKDHAIIAEIDGTVRFGRDYKNKRRIIIEPNDDTIEPVEYLIPKGKPFHLQDGDVIEKGEYILDGNPAPHDILAIKGVEALASYLVNEIQEVYRLQGVLINDKHIEVIVRQMLQKVEITESGDTGYIPGDHVDRIELEEINERLIEEGKKPGSGNPVLLGITKASLQTPSFISAASFQETTRVLTEAAVAGKMDTLQGLKENVIVGRLIPAGTGGMTNQIRRIATARDELIIDERRKTSGSAEANAMLVDMTNNAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: CYC2_CLITE
Sequence: MAYVRLTSLAVLFFLAASVMLNVKKTEGGEFLKCGESCVQGECYTPGCSCDWPICKKNHIIATNAKTVNQHRLLCESHEDCFKKGTGNYCAFFPDSDVHFGWCFYAESDGYLLKDFFKMSKDNLKMPMTIIN
What is the function of this protein?
Probably participates in a plant defense mechanism (Probable).  Not active against Gram-negative bacteria E. coli ATCC 700926, K. pneumoniae ATTC 13883 and P. aeruginosa ATCC 39018 at concentration up to 100 uM (PubMed:21596752).  Has cytotoxic but no hemolytic activity (PubMed:21596752).
What are the official names of this protein?
Cliotide T2.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: TRA2B_MOUSE
Sequence: MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMSTRRRHVGNRANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKERANGMELDGRRIRVDFSITKRPHTPTPGIYMGRPTYGSSRRRDYYDRGYDRGYDDRDYYSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRSRSRSRSYSPRRY
What is the function of this protein?
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing (PubMed:28785060).  Can either activate or suppress exon inclusion.  Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2.  Activates the splicing of MAPT/Tau exon 10.  Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX.  Binds to the AG-rich SE2 domain in the SMN exon 7 RNA.  Binds to pre-mRNA (By similarity).
What are the official names of this protein?
Transformer-2 protein homolog beta, TRA-2 beta, TRA2-beta, Silica-induced gene 41 protein, SIG-41, Splicing factor, arginine/serine-rich 10, Transformer-2 protein homolog B.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BBS12_PONAB
Sequence: MVMACRVVNKRRHMGLQQLSSFAETGRTFLGPLKSSKFIIDEECHESVLISSTVRLLESLDLTSAVGQLLNEAVQAQNNTYRTGISTLLFLVGAWSSAVEECLHLGVPISIIVSVMSEGLNFCSEEVVSLHVPVHNIFDCMDSTKTFSQLETFSVSLCPFLQVPSDTDLIEELHGLKDVASQTLTISNLSGRPLKSYELFKPQTKVEADNNTSRTLKNSLLADTCCRQSILIHSRHFNRTDNTEGVSKPDGFQEHVTATHKTYRCNDLVELAVGLSHGDHSSMKLVEEAVQLQYQNACVQQGNCTKPFMFDISRIFTCCLPGLPETSSCVCPGYITVVSVSNNPVIKELQNQPVRIVLIEGDLTENYRHLGFNKSANIKTVLDSMQLQEDSSEELWANHVLQVLIQFKVNLVLVQGNVSERLIEKCINSKRLVIGSVNGSVMQAFAEAAGAVQVAYITQVNEDCVGDGVCVTFWRSSPLDVVDRNSRIAILLKTEGINLVTAVLTNPVTAQMQIKEDRFWTCAYRLYYALKEEKVFLGGGAVEFLCLSCLHILAEQSLKKENHACSGWLHNTSSWLASSLAIYRPTVLKFLANGWQKYLSTLLYNTANYSSEFEASTYIQHHLQNATDSGSPSSYILNEYSKLNSRIFNSDISNKLEQIPRVYDVVTPKIEAWRRALDLVLLALQTDSEIITGHGHTQRNSQELTGFLFL
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.  As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.  Involved in adipogenic differentiation.
What are the official names of this protein?
Bardet-Biedl syndrome 12 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family. BBS12 subfamily.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Located within the basal body of the primary cilium of differentiating preadipocytes.
Protein: CSSS_BACSU
Sequence: MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTTIENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSSFIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLAYTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKDEIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDLENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARKELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKNDGPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVPK
What is the function of this protein?
Member of the two-component regulatory system CssS/CssR required to control the cellular response to secretion stress.  Required for the transcription of htrA.  Could detect misfolded proteins at the membrane-cell wall interface and then activate CssR by phosphorylation.
What are the official names of this protein?
Sensor histidine kinase CssS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SERC_XENNA
Sequence: MNQVYNFSAGPAMLPAEVLRRAEQELCNWHGLGTSVMEISHRSKEFIAVAAEAEKDLRDLLAIPENYNVLFCHGGARGQFSALPQNLLGDKSTADYIVSGYWSECAAKEAEKYCTPNIIDIRSNTDGITSVKPMNEWALSSDAAYVHYCPNETIEGTAIFEEPDFGDDKIVIADYSSTILSAPIDVSRYGVIYAGAQKNIGPAGITVVIIREDLLGKAHKHIPSILDYTVQVKADSMYNTPPTFAWYLSGMVFKWLKEQGGLQEISKRNLAKAELLYRAIDNSNLYINRVALQNRSIMNVPFQLVNPALDGKFLEEAYAHGLHALKGHKVAGGARASIYNAMSYEGVKALVEFMADFERRNG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXL6_ARATH
Sequence: MFRGKIFVLSLFSIYVLSSAAEKNTSFSALFAFGDSVLDTGNNNFLLTLLKGNYWPYGLSFDYKFPTGRFGNGRVFTDIVAEGLQIKRLVPAYSKIRRISSEDLKTGVCFASGGSGIDDLTSRTLRVLSAGDQVKDFKDYLKKLRRVVKRKKKVKEIVSNAVFLISEGNNDLGYFVAPALLRLQSTTTYTSKMVVWTRKFLKDLYDLGARKFAVMGVMPVGCLPIHRASFGGVFGWCNFLLNRITEDFNMKLQKGLTSYAVEYDFKDAKFVYVDIYGTLMDLVKNPMAYGFTEAKKACCCMPNAIIPCFHPDKYVFYDFAHPSQKAYEVISKPIVYQIAKGLA
What is the function of this protein?
Required for the formation of pollen coats and male fertility.
What are the official names of this protein?
GDSL esterase/lipase EXL6, Family II extracellular lipase 6, Family II lipase EXL6.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, pollen coat. Note=Localized in small granules in the tapetal cells.
Protein: LSPA_SHEON
Sequence: MPLTWKDSGLRWYWVVVLVFLADQLSKQWVLANFDLFESVQLLPFFNFTYVRNYGAAFSFLSEAGGWQRWLFTIVAVGFSSLLTVWLRKQSASLLKLNLAYTLVIGGALGNLVDRLMHGFVVDFIDFYWGKSHYPAFNIADSAIFIGAVLIIWDSFFNSQSEQDKTEEVK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MMS6_MAGSA
Sequence: MGEMEREGAAAKAGAAKTGAAKTGTVAKTGIAAKTGVATAVAAPAAPANVAAAQGAGTKVALGAGKAAAGAKVVGGTIWTGKGLGLGLGLGLGAWGPIILGVVGAGAVYAYMKSRDIESAQSDEEVELRDALA
What is the function of this protein?
Promotes the formation of magnetite in Fe(2+)-rich conditions, when magnetite is not readily formed (PubMed:27112228).  Binds Fe(3+) and Fe(2+) (PubMed:12496282, PubMed:23857056, PubMed:27112228) (Probable).  May play a role in nucleation of magnetite crystal formation (Probable) (PubMed:22716969).  May help control production of crystals with a specific morphology (Probable) (PubMed:22716969, PubMed:27759096).  Greatly improves the formation of magnetosome-like magnetite crystals in vitro (PubMed:12496282).  Isolated short protein, probably residues 75-133, binds up to 18 Fe(3+) per monomer and self-assembles into micelles about 21-26 nm in diameter; the C-terminal 21 residues also self-assemble (PubMed:23857056).
What are the official names of this protein?
Magnetite biomineralization protein Mms6, Magnetosome protein Mms6.
What is the protein family that this protein belongs to?
Belongs to the magnetosome Mms6 family.
What are the subcellular locations of this protein?
Magnetosome membrane; Single-pass membrane protein. Note=Tightly associated with magnetite crystals (PubMed:12496282). Tagged protein forms straight lines with a punctate pattern extending along most of the cell associated with its inner curvature, in the correct position to be associated with magnetosomes. Under aerobic conditions, when magnetites cannot form, or in the absence of iron, the protein is dispersed in the cell, probably in the inner membrane; as magnetosomes form tagged Mms6 localizes in a line that corresponds to the position of magnetite crystals (PubMed:27481925). Short protein seems to localize specifically to magnetosomes which have magnetite crystals (Probable).
Protein: TAL_SHESH
Sequence: MPNTLEQFKSITTIVADTGDIEAIKRYQPEDATTNPSLILKAAQIPDYAHLIENAIEWAKSQSDSIEQQVEDAGDKLAVNIGVEILKIVPGRISTEVDARLSFDKAGSITKAHKLIKLYKEAGIDKSRILIKLASTWEGICAAKELEQEGINCNLTLLFSFAQARACAEAGVYLISPFVGRILDWYKKDTGLEYSSVEDPGVVSVTEIYNYYKRHGFNTVVMGASFRNTGEIIELAGCDRLTIGPALLEELANSQTEVVRKLIPTETVVDAADPLTEAQFRWEFNEDPMAVEKLAEGIRNFAIDQGKLEVMLKEKLAC
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTC_ARCFU
Sequence: MKHLLSMADLEKDELFEILKLAEKLKEERYKGVVTDYLKNKSLAMIFELPSTRTRVSFEVAMTDLGGHALYLGWDELQLGRGEPIKDTARVLSRYVHAVMMRVREHSTIEEFARYSTVPVINGLSNLEHPCQVIADLLTIYEYRGDFKDVTLAWVGDGNNVCNSMILAAALTGMKMVISTPENYDPNPEIVKKAEEMGAKLRFVRDPKEAVKEADVIYTDVWTSMGQEAEKEARLKAFQPYQVSDELLKFSKDDVVVMHCLPAHRGEEITDEVMEGKHSIVFDQAENRLHAQKAILLKLLGKESEVY
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THAP2_MOUSE
Sequence: MPTNCAAAGCAATYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSLKLKSRNLLKTNNSFPPTGPCNLKLNGSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRKKMKTCLQRERRATRRWIKATCFVKSLEASNMLPKGISEQILPTALSNLPLEDLKSLEQDQQDKTVPIL
What are the official names of this protein?
THAP domain-containing protein 2.
Protein: ERM1_ENTFL
Sequence: MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLIHQDILQFQFPNKQRYKIVGSIPYHLSTQIIKKVVFESHASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTVTYEQVLSIFNSYLLFNGRK
What is the function of this protein?
This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.
What are the official names of this protein?
rRNA adenine N-6-methyltransferase, Macrolide-lincosamide-streptogramin B resistance protein.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Protein: RK33_NICSY
Sequence: MAKGKDVRVTVILECTSCVRNSVDKVSRGISRYITQKNRHNTPNRLELKKFCPYCYKHTIHGEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NUON_MYCTU
Sequence: MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDALAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTNVKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAGSEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMFFTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROE_PROMS
Sequence: MISSKTSFIALIGNPVSHSLSPIMQNAALQYLGLDLIYIAVPCKDEDLELVLNSFKKINCKGLNITIPHKEKVLTLCSEISPIANKLKAINTLKLNSEKKWSATNTDVEGFIYPLKNLNLAKKKSIVLGSGGAARSVIQGLINLNLSTISVISRNKSSLDELIKNFGNEIQLQGLLNSDDQAQVLIREADLIVNTTPAGMKTTKYKNNVMPYGETFWRSLNSQTIVYDLIYNPAPTTLLKFSARKGCKTIDGLEMLVAQGIKSLSFWTDGLEVPFHVMNDALKKYL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: Y1388_BRUA2
Sequence: MKPLLSLDRVSVSRDGRNVLDKLSLSLAAGERLALIGDNGVGKTTLLRTIVGLEPASGEITAFGINCRNESDFRKIRAKAAYLFQDPDDQLFCPTVIDDVAFGPLNLGLSRQEAMELSNGLLHDLGLGHLAGRITHHLSGGEKRLVSLAAVLAMQPQVLLLDEPTNALDEKHLERMLAILSAQKIAMIIVSHDWEILERLTDRAVVLRNGKLLPAMLHRHSQWSEQVHLHYVEAEGSAL
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein BAB1_1388.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PFKA_SPICI
Sequence: MLKKIGILTSGGDSQGMNAAIAGVIKTAHAKGLETYIIRDGYLGLINNWIEVVDNNFADSIMLLGGTVIGSARLPEFKDPEVQKKAVDILKKQEIAALVVIGGDGSYQGAQRLTELGINCIALPGTIDNDITSSDYTIGFDTAINIVVEAIDRLRDTMQSHNRCSIVEVMGHACGDIALYAGIAGGADIISINEAALSETEIADRVAMLHQAQKRSVIVVVSEMIYPDVHKLAKLVESKSGYITRATVLGHTQRGGNPTAMDRYRAFQMAQFAVEQIIAGVGGLAIGNQGDQIIARPIMEALSIPRSSRKEIWAKFDQLNQNIYQKS
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END4_ALKOO
Sequence: MLNIGCHLSSSKGYKAMGKDAISINANTFQFFTRNPRGSKAKAMDLKDVEGLLQLMEENKFAKILAHAPYTLNPCSADERTREFAMEVLVDDLARMEYLPNNFYNFHPGNHLKQGVEVGIEYIVNSLNDVLKPDQTTTVLLETMSGKGTEIGKNFEELKQIIDGIKLSNKVGVCLDTCHVYDAGYDIVQDLDGVIQEFDRIIGLDKLYAIHLNDSKNPFASHKDRHAKIGEGYIGEEGIVRIINHPKLRHLPFFLETPNDLEGHGEEIKMLREAYRDESIL
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: HGD_XANOP
Sequence: MHNPQHYMTGFGNEFATEAVAGSLPVGQNSPQRVAHGLYAEQLSGTAFTAPRGENRRSWLYRIRPAAVHGRFSLIEQSRLHNDFGGGPVPPDQMRWSPLPLPATPTDFVDGLYTMAGNGSPEAMTGVAVHLYAANASMHGRFFYNADGELLLVPQLGRLRVCTELGVLELEPQQIGVIPRGVRFRVELLDSAARGYVCENFGGLLRLPDLGPIGANGLANPRDFETPRAAFEQRDGAFELVAKFQGHLWRADIDHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLTSPSDTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMGLVHGVYDAKAEGFAPGGASLHNCMSGHGPDAATFDKASQADLTRPDVIAETMAFMFETRAVLRPTQQALSAAHRQADYQQCWSGLRAAFQHPPAKNTTSVLR
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: COX2_AMICA
Sequence: MAHPMQLGFQDAASPVMEELLHFHDHALMIVFLISTAVLYIIVVTVTTKLTDKYVLDAQEIEMVWTIMPAVVLI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MURC_LEUMM
Sequence: MSKKYYFIGIKGTGMGPLAQILHDQGNEVLGSDIDTYTYTQAPLEAAGIKILTFDARNIDANQDAIFVRGNAFNNDQIEVARALEIGVTMVSYPEAVQEQISQTTSIAVAGAHGKTSTTGLLAHVLKNIAPTSYLIGDGTGRGVPNSQFFVVEADEYRRHFKDYAPDYAILTNIDFDHPDYYTGIEDVTSAFADFANNVKKAIFAWGDDEHLRSLKPSADVYYYGVNPERDDFVATNIHKSTQGSHFDVVFRGKDLGEFAVPLFGQHGILNALAVIAVSYMEEVDLDLIRQYLLTYQGVKRRFSEKQIADITVIDDYAHHPTEITATLDAARQKYPNKKIIAIFQPHTFSRVIAYKDEFASSLEAADQVYLANIFGSAREQAGTITSKDLGSEISKFGGIIEENDMSLLMPYENAVMVFMGAGDIEKYEFAYEKLLGQLRTDLT
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.