PharMolix/UniProtQA huggingface dataset:
Protein: SRRT_ARATH
Sequence: MADVNLPPSDSVDNRLPEKSTSSSPPPPPPSSSLPQQEQEQDQQQLPLRRERDSRERRDERDIERPPPNRRERDRSPLPPPRRDYKRRPSLSPPPPYRDRRHSPPQRRSPPQKRYRRDDNGYDGRRGSPRGGYGPPDRRFGYDHGGGYDREMGGRPGYGDERPHGRFMGRYQDWEGGRGGYGDASNSGNPQRDGLMSYKQFIQELEDDILPSEAERRYQEYKSEYITTQKRAFFNTHKEEDWLKNKYHPTNLLSVIERRNDLAQKVAKDFLLDLQSGTLDLGPAVTALNKSGRTSEPNSEDEAAGVGKRKRHGMGGAKENELLSAAPKAPSFTSDPKRILTDVEQTQALVRKLDSEKKIEENVLQGSETEKSGREKLHSGSTGPVVIIRGLTSVKGLEGVELLDTLVTYLWRVHGLDYYGKVETNEAKGLRHVRAEGKVSDAKGDENESKFDSHWQERLKGQDPLEVMAAKEKIDAAATEALDPHVRKIRDEKYGWKYGCGAKGCTKLFHAAEFVYKHLKLKHTELVTELTTKVREELYFQNYMNDPNAPGGQPATQQSGPRDRPIRRKPSMENRLRDDRGGRRERDGRANGNDRNDRSEDQQRGDNDGGNPGEVGYDAFGGQGGVHVPPFLSDINPPPMLMPVPGAGPLGPFVPAPPEVAMQMFRDPSGPNPPFEGSGRGGPAPFLLSPAFRQDPRRLRSYQDLDAPEEEVTVIDYRSL
What is the function of this protein?
Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery.  Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs.  Does not participate in sense post-transcriptional gene silencing.  Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression.  Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing.  Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA).  Required for pre-mRNA splicing.
What are the official names of this protein?
Serrate RNA effector molecule.
What is the protein family that this protein belongs to?
Belongs to the ARS2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Localizes to nuclear dicing body (also named D body), a nuclear body distributed throughout the nucleoplasm involved in miRNA processing.
Protein: GLMM_BACHK
Sequence: MGKYFGTDGVRGVANKELTPELAFKIGRFGGYVLTKDTDRPKVIIGRDTRISGHMLEGALVAGLLSTGAEVMRLGVISTPGVAYLTKALDAQAGVMISASHNPVQDNGIKFFGSDGFKLTDEQEAEIEALLDKEVDELPRPTGTNLGQVSDYFEGGQKYLQYIKQTVEEDFSGLHIALDCAHGATSSLAPYLFADLEADISTMGTSPNGMNINDGVGSTHPEVLAELVKEKGADIGLAFDGDGDRLIAVDEKGNIVDGDQIMFICAKYMKETGQLKHNTVVSTVMSNLGFYKALEANGITSDKTAVGDRYVMEEMKRGGYNLGGEQSGHIILLDYITTGDGMLSALQLVNIMKMTKKPLSELAGEMTKFPQLLVNVRVTDKKLALENEKIKEIIRVVEEEMNGDGRILVRPSGTEPLIRVMAEAPTQEVCDAYVHRIVEVVKAEVGAE
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ARF1_SCHPO
Sequence: MGLSISKLFQSLFGKREMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYRNISFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRERISEAHEELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLHSLRHRQWYIQATCATSGDGLYEGLEWLSTNLKNQ
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: FMT_ACIBY
Sequence: MKIIFAGTPEFAATALAALLKTSHEIIAVYTQPDRKAGRGQKLTPSPVKQLALEHNIPVYQPLHFKASTEEGLAAQQELAALGADVMVVAAYGLILPQAVLDTPKYGCLNIHGSLLPRWRGAAPIQRAIATGDDETGITIMQMAAGLDTGDMMYKTYCPITSEDTSATLHDKLAAQGATAICAVLESEETLQKYLAEREVQDESLTVYAHKLVKSEARIDWSMNAVQVDRNIRAFNPWPVAFIQLDENNALRVWNSTISSQSKVNAQAGEIIAIDKQGVHVACGENTFICLTSVQWPGGKALNAQQIAQTQKLHVGQILP
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RT106_YARLI
Sequence: MYQPPRPFELPSDLAAGITSLYRENADAKVIIDSLVKLAYDSGKEQSELVHKKAKVDGPPATLSESIVSKLKIFLGINQVSVVLPIRKKLNVFIGADPRGKTWVWVSSKEDGSVDDMYPATDTADFRCVACLPVPDRSGTPLFNIVFVPGGAAQEVTTPPQPLVFSVPEEPAKKAFDGSLFLQGKDKNQFMYKDLILLGCQGISLPISVPDTEIFGEKFHVLAHKGAREGYLFFMQNEVIFGFKKPLLCMNTEDIESISFSTITRLTFNINIVLKSAPDVAMEFSLIDQSHYGEIAGFMERIAVKNESFDDKLKAKTFMKNQQPDNILAVAQNEAENEVPVAYDDEDEEDDENYTGESSASDGDADESDEEEAEEMEEQEREYDEELGDDEVEHDEDLG
What is the function of this protein?
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing.  Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA.  Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
What are the official names of this protein?
Histone chaperone RTT106.
What is the protein family that this protein belongs to?
Belongs to the RTT106 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: UVRB_PHOLL
Sequence: MSKVFKLHSDFQPGGDQPEAIRQLQEGLEDGLAHQTLLGVTGSGKTFTVANVIANLNRPTMVLAPNKTLAAQLYSEMKDFFPENSVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVIVVASVSAIYGLGDPDSYLKMMLHLTNGMMIDQRSILRRLAELQYTRNDQAFQRGTFRVRGEVIDIFPAESDEHALRVELFDDEVERLSLFDPLTGQVQYHVPRYTVYPKTHYVTPRERIIQAMEAIKIELEQRRKVLLANGKLLEEQRITQRTQFDLEMMNELGYCSGIENYSRYLSGRTEGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRSRKETLVEYGFRMPSALDNRPLRFEEFEALAPQTIYISATPGKYELEKSSGDVVEQVVRPTGLLDPEVEVRPVATQVDDLLSEIRIRAVKNERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLHGKAILYGDKITDSMAKAIGETERRRAKQQIFNEKHGIVPKGLNKKINDILQIGQPAGGKRKGRGKAVATAETFSNLSAKELESKIRELEAKMYQHAQDLEFEQAASVRDQVQALREQFIANF
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN177_HUMAN
Sequence: MAAGWLTTWSQNSVTFQEVAVDFSQEEWALLDPAQKNLYKDVMLENFRNLASVGYQLCRHSLISKVDQEQLKTDERGILQGDCADWETQLKPKDTIAMQNIPGGKTSNGINTAENQPGEHSLECNHCGKFRKNTRFICTRYCKGEKCYKYIKYSKVFNHPSTLRSHVSIHIGEKTLEFTDCRKAFNQESSLRKHLRTPTGQKFQEYEQCDMSFSLHSSCSVREQIPTGEKGDECSDYGKISPLSVHTKTGSVEEGLECNEHEKTFTDPLSLQNCVRTHSGEMPYECSDCGKAFIFQSSLKKHMRSHTGEKPYECDHCGKSFSQSSHLNVHKRTHTGEKPYDCKECGKAFTVPSSLQKHVRTHTGEKPYECSDCGKAFIDQSSLKKHTRSHTGEKPYECNQCGKSFSTGSYLIVHKRTHTGEKTYECKECGKAFRNSSCLRVHVRTHTGEKPYKCIQCEKAFSTSTNLIMHKRIHNGQKLHE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 177.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYB_NYCHU
Sequence: MTNIRKTHPLAKIINNSLIDLPAPSNISSWWNFGSLLGICLGLQILTGLFLAMHYTADTATAFNSVTHICRDVNYGWVLRYLHANGASMFFICLYLHVGRGIYYGSYLYKETWNMGVVLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGNDLVEWIWGGFSVDKATLT
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RIG_HUMAN
Sequence: MPFFSSCLCPSHYSGPSLPSSTSSSLPTGPENQLGFVLLQAMVHHANSSCVRNAFWLQITEKLTPALSIIISVVYLRCPEMVENRIGFLLNVKDSKTLSVVGPHPKPCIL
What is the function of this protein?
May serve as a molecular marker for or play a role in the malignant progression of glioblastomas.
What are the official names of this protein?
Putative protein RIG, Protein regulated in glioma.
Protein: XKDC_BACSU
Sequence: MTKRTIEQILDELRRGRRPLLADKPAESDASRYDCLRCKDQGGYLVRQNGLEVWTMCSCMAERKVKRLLGASEITHAFRQLGFKEFRTEGKPQAIKDAFECTKEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELMRTCYVPVIYFPFVEGFTDLKNDFALLEAKLNRMKQADVLFIDDLFKPVNGKPRATDWQLEQMYSVLNYRYLNHKPILLSSELTIEGLVRVDEALGTRIYEMCSDYLVIIKGAAYELNHRLEGVR
What is the function of this protein?
May function as a transcriptional antiterminator.
What are the official names of this protein?
Phage-like element PBSX protein XkdC.
What is the protein family that this protein belongs to?
To B.subtilis YqaM.
Protein: RPIA_PROM4
Sequence: MEDLQTQMKEAVAKAAIEQIHDGMVLGLGSGSTAALMIKALGAKISSGHLKDIVGVTTSFQGEVLATELGIPLQGLSAVSQIDLAIDGADEVDSNFQLIKGGGACHVQEKLVASLAERFVVVVDSSKIVKTLNLTFKLPVEVLPSAWQLVKNKIHEIGGVSQLRMAQKKAGPIVTDQGNLVLDVTFAGGINDPQTLEKQINNIPGVLENGLFVNLADEVLVGEIVSGTPGVKSLQKI
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: NTPPA_BARQU
Sequence: MGNIRETFFKKTCSEEIQLVLASASPRRLALLAQIGLDPHQVYATNIDETPKLREHPANLAKRLAKEKALKAQETFLWCNQNGKSNASAQKIVILAADTVVAVGRVILPKPESEDQAYECLRFLSGRSHKVYGAVCALNECGKITVKLVESRVRFRRLTSSLMEAYLNSGEWEGKAGGYAIQGKASAFVVHIAGSYSNVVGLPLAETMDLLTAYQYPLLSNWVAKTL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_LEIXX
Sequence: MADDKSTNEAAAKPVAEKATATALAKKAPAKAAAADKAAPAAKGETVAAKPAKASAKKDVAAPREQVLKVHHLRPAAGAKKEKTRVGRGEGSKGKTAGRGTKGTKARYQVRPGFQGGQLPFHMRTPKLRGFKNPFRVEYQVVNLEKLAELYPAGGDVTVAALVAKGAVRKNEKVKVLGNGDIAVKLNVAVDKVSGSAEQKIVAAGGSVNR
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PYRB_DEHMB
Sequence: MTHIPKTPADTETLLSEVQGWKHRHVLDLDNFSREELDMVMQTAGVMLDILSRPVKKVPALKGKTIATLFYEPSTRTRSSFELAAKSLSADVLNLNVSQSSISKGESLLDTLDTLESLGADMVVMRHPLSGAPYLAANNCHANIINAGDGWHAHPSQALLDIFTILRHKSSLEGLKITLIGDIKHSRVAHSNIWGLSKMGAKITLCAPYTLLPEGLNTNSKIFPEVTLETDIKQAVSGADVVMGLRLQRERQQSGLLPGIREYARYFQLNEEILKLAKSNALVMHPGPVNEDIELSQSVVHGEQSVIKEQVKNGVAVRMALFYLCSGSKEI
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: YL269_MIMIV
Sequence: MENIEKKCQPETINEDNNDEKQYEPEIIEFTVNGFNYVVKFSKTCVPSIHITCTHVEEFYSWSFTTDKNIDNQIPTNTIENVAKQDIKIHPKMLFDMFCSFKNNSLEKMFELVFPKDFKTHETNLNIYIFTTIAYSKYVDHKYISLAQVEISEYDRFLLKSSKANKLFMEQTKKELNDMREINETLKNEINNTKNIFNESIKNLVENFECEYAKDKTIESIKTEEENFEDFEKLMKKFLANPKCMKYIIDAISNSNVFATKDEL
What are the official names of this protein?
Uncharacterized protein L269.
What is the protein family that this protein belongs to?
Belongs to the mimivirus R73/L269/L862 family.
Protein: RS14Z_STRP3
Sequence: MAKKSMIAKNKRPAKHSTQAYTRCEKCGRPHSVYRKFKLCRVCFRELAYKGQIPGVVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: RL30_PSEAB
Sequence: MATVKVTLVKSLNGRLANHKACVKGLGLRRINHTVEVQDTPENRGMINKAYYLLRVEG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: DAT12_ORYSJ
Sequence: MAPPPSLAPDRGGGEPDDALRLRARAAAAAGDAPAPQQQQEQRHQEQQQQLLWYRASAPAHRRVRESPLSSDAIFRQSHAGLLNLCIVVLVAVNSRLIIENLMKYGLLIRAGFWFSGTSLADWPLLMCCLTLPTFPLAALMVEKLAQRKLISKHVVILLHIVITTSVLVYPVVVILKCDSAVLSGFVLMFLASIIWLKLVSFAHTNYDIRMLSKSIEKGVTHDISIDPENIKWPTFKRLSYFMLAPTLCYQPSYPRTTYIRKGWVVRQLIKCLVFTGLMGFIIEQYINPIVKNSKHPLKGNFLNAIERVLKLSVPTLYVWLCMFYCFFHLWLNILAELLCFGDREFYKDWWNAKTVEEYWRMWNMPVHKWVIRHIYFPCIRNGFSKGVAILISFLVSAAFHELCVAVPCHIFKFWAFIGIMFQIPLVFLTKYLQDKFNNTMVGNMIFWFFFSILGQPMCVLLYYHDVMNRQQAQTNR
What is the function of this protein?
Involved in triacylglycerol (TAG) synthesis.  Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA.
What are the official names of this protein?
Diacylglycerol O-acyltransferase 1-2, OsDGAT1-2.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TBA_LEPDS
Sequence: MRECISVHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGTGDDSFNTFFSETGSGKHVPRAVYVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAVYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISSEKAYHEQLTVSEITNTCFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGLDSTEADDTAGEEF
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: METAS_SALPC
Sequence: MPIRVLDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDARESRNTPAEHLNNFYCNFDDICDQNFDGLIVTGAPLGLVEFNDVAYWPQIRQVLEWAKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAHTLAGEYFRDVEAGLNPEVPYNYFPKNDPQNIPRATWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO4_FRATF
Sequence: MTKLRKIIHIDMDYFFAQVEEKANPSLKDKPFAVGGTNPKRGVISTCNYIAREYGVRSAMPTAIAMQKCPNLILLNTDFAKYKAASAVIRDIFYSFTDKVEPLSLDEAYLDVTDVKEYKNSATLIAQAIKQEIFNKTGLTGSAGVAPNKLLAKIASDINKPNGLYVVTPKQVDSFVKDLPVKKLFGVGKVSQEKLKSMGVETCLDLQQLSLATLVDKFGKFGSSLYNYARGIDNREVNPVRIRKSVSVENTYLEDLKTLGACLEKLPSLYDKLTSRMTEEHYKSIIGIVVKFTDTKFNKTSLTRVAKILDKEMLKNLIIELHQKRNHPIRLIGIGVKLGEIDDKQMDLF
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y550_METJA
Sequence: MNQIINDNYREFLKKLRERHLKKRKVKDKNKPIAVWMQDDIYRDFSIGKSLTIILRTEGCYYAKEGGCLMCSYLMDSSPEKITAENIINQFNYAIEKYKEKIKDLKDFSVKIFTSGSFLDDREVPKEARNYIFKKLSEFDNLKEVAIESRPEFIDEDKLNEIRKYLDVNVEIGVGIESFNEEIREKAINKGITNEQIIRAIELAKNYNIGIKAYLLIKPLFITEKEAIYDSISSANKCIELGCSRISFCPATVHKGSVMEFFFNKNQYRPPFLWSIIEILKEVKKSNPKALIMCDTSGVGSERGAHNLYNCKCNKLIKERLERFTLTQDINVLNVECECKNIWNAYIEVENKNIVPLGDERKLLL
What are the official names of this protein?
Uncharacterized protein MJ0550.
Protein: GRPE_FRAP2
Sequence: MGKEEKNNIEDKALDNEQEMDQESTSKAVEELSIEEQLERARDTIKELEETCDSFKDEALRARAEMENVRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALKHEVKLEEAIAMKEGIELTSKMLVDTLKKNGLEELDPKGEKFDPNLHEAMAMIPNSEFEDNTIFDVFQKGYMLNGRVVRAAKVVIVKN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECK_DANRE
Sequence: MSGCLQILTVLLCCRFWALVFSQDQSCCVHHAADIPRCRDACEQLASIRSESRLRHLLHRLPSYCPETLSELWICINNSLPGASRKSDGWVGLGCCELAISAECRRDCKQASSKNDISKVCKKDTENPLYSCITKNEMGSVCCSYAGRHTTCREYCQAIFRTDSSPTVSQISAVKEYCQSVSPPLILCVENYTRLHPTHRPIDSLHCCDRAEEAHCQLACKRILRTLSTEQEIMDGLISECGSQPLPQDPLWQCFLGSAHPPANTDPESPPIAKMDSAKLHCCFKANTSICRNMCVEISTSWGTQSWQEFDQHCEYNPVEMDLITCLADVREPCQLGCKELSYCTNFNNRPTELFRSCNVQSDQGALNDFKLWSNGSIRMPLMNIPVLDIRRCRPEMWKTVACALQIKPCYSRSRGSVICRSDCVEILRQCGDRRRFAEAQTPERICDLLSPTDDPERCIPLNRYLTASELESSVEEVIHPCNPNPCPSSHLCHVNRKGCHVGHDCLPYYCVPGCKLGEASEFLVPADARLQVPVHSAQPGCYEVCVCGQSGRLENCAEMPCFDTSKSCQIAGQRRSHGSSFRVDCNPCSCFAGDAVCSSRQCVRSDSSEEDRRLFTGLPCGCADHFVPVCAGNGRTYPSACVARCVGFTDSQFVFGSCRSFDPCSPNPCQRNQRCVPRRQVCLTDLSEFPCPQYECVSRPSSCDQKLLDPVCDTDNMEHANLCVLNLRGKTLAYSGHCQDACRRPREVCAHNGESYSTVCEAFSERVAVDYQGRCHAVGLESEFGSDSGCNAVPCPPLASDACQPVTPPGACCPVCAGMLRILWNKAQMNIFAKLNRDQPVSLHDILKILRLHVSVPQCDIFGYLSINSEIIILIAPVDQQPTPLQIEACSKEAEKIDSLINSGSPTLVSHVPLSAFLSSELQLSSVRSSSCVSISVCVLLLLCSLILTLTSDL
What is the function of this protein?
Functions together with adgra2 to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b) (PubMed:26051822, PubMed:26657775).  Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:26051822, PubMed:26657775).  Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7.  Adgra2 is then required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex.  Also acts as a serine protease inhibitor (By similarity).
What are the official names of this protein?
Reversion-inducing cysteine-rich protein with Kazal motifs.
What is the protein family that this protein belongs to?
Belongs to the RECK family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Note=Colocalizes with adgra2 at the plasma membrane.
Protein: DXS_HAEDU
Sequence: MQNKYPLLSQIDSPEDLRLLGKEDLSALANELRTYLLDSVSQTSGHLASGLGVVELTVALHYVYQTPFDQLIWDVGHQAYPHKILTGRRDQMHTIRQKNGIHPFPWREESPYDVLSVGHSSTSISAGLGIAVAAQKENAGRKTVCVIGDGAITAGMAFEAMNHAGALHTDMLVILNDNEMSISENVGALNNHLARIFSGSLYTSMRDGSKKVLDKVPTIKNFMKKSEEHMKGVIFSPDSTLFEELGFNYIGPIDGHNIEELVKTLTNMRELKGPQFLHVRTKKGKGYEPAENDPISYHGVPRFDPASGKLPQSKIVPTYSDIFGNWLCEMAENDEKIIGITPAMREGSGMVEFSKRFPTQYFDVAIAEQHAVTFAAGLAIAGYKPVVAIYSTFLQRAYDQLIHDIAIQNLPVIFAIDRAGVVGADGQTHQGAFDLSFMRCIPNMTIMCPADENEMHQMLYTAYKMQTPTAIRYPRGNARGIALQPMAELAVGKARIIHQGKKVAILNFGALLSEAQEVAISHNYTLVDMRFVKPLDKTLISELADSHSLLVTLEENAIQGGAGSAVNEYLQQIGKIKPLVLIGLPDMFIPQSTQQESYADFGLDAKGIDQKIKLALS
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: PREP_YEAST
Sequence: MLRFQRFASSYAQAQAVRKYPVGGIFHGYEVRRILPVPELRLTAVDLVHSQTGAEHLHIDRDDKNNVFSIAFKTNPPDSTGVPHILEHTTLCGSVKYPVRDPFFKMLNKSLANFMNAMTGPDYTFFPFSTTNPQDFANLRGVYLDSTLNPLLKQEDFDQEGWRLEHKNITDPESNIVFKGVVYNEMKGQISNANYYFWSKFQQSIYPSLNNSGGDPMKITDLRYGDLLDFHHKNYHPSNAKTFTYGNLPLVDTLKQLNEQFSGYGKRARKDKLLMPIDLKKDIDVKLLGQIDTMLPPEKQTKASMTWICGAPQDTYDTFLLKVLGNLLMDGHSSVMYQKLIESGIGLEFSVNSGVEPTTAVNLLTVGIQGVSDIEIFKDTVNNIFQNLLETEHPFDRKRIDAIIEQLELSKKDQKADFGLQLLYSILPGWTNKIDPFESLLFEDVLQRFRGDLETKGDTLFQDLIRKYIVHKPCFTFSIQGSEEFSKSLDDEEQTRLREKITALDEQDKKNIFKRGILLQEKQNEKEDLSCLPTLQIKDIPRAGDKYSIEQKNNTMSRITDTNGITYVRGKRLLNDIIPFELFPYLPLFAESLTNLGTTTESFSEIEDQIKLHTGGISTHVEVTSDPNTTEPRLIFGFDGWSLNSKTDHIFEFWSKILLETDFHKNSDKLKVLIRLLASSNTSSVADAGHAFARGYSAAHYRSSGAINETLNGIEQLQFINRLHSLLDNEETFQREVVDKLTELQKYIVDTNNMNFFITSDSDVQAKTVESQISKFMERLPHGSCLPNGPKTSDYPLIGSKCKHTLIKFPFQVHYTSQALLGVPYTHKDGSALQVMSNMLTFKHLHREVREKGGAYGGGASYSALAGIFSFYSYRDPQPLKSLETFKNSGRYILNDAKWGVTDLDEAKLTIFQQVDAPKSPKGEGVTYFMSGVTDDMKQARREQLLDVSLLDVHRVAEKYLLNKEGVSTVIGPGIEGKTVSPNWEVKEL
What is the function of this protein?
Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (PubMed:15772085, PubMed:25176146).  Preferentially cleaves the N-terminal side of paired basic amino acid residues (PubMed:35997162).  Also degrades other unstructured peptides (PubMed:25176146).  May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (PubMed:35997162).
What are the official names of this protein?
Presequence protease, mitochondrial, PreP, Metalloprotease of 112 kDa, Pitrilysin metalloproteinase, Protease M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family. PreP subfamily.