PharMolix/UniProtQA huggingface dataset:
Protein: I5P2_MOUSE
Sequence: MDQSVAIQETLVEGEYCVIAVQGVLCKGDSRQSRLLGLVRYRLENDAQEHALFLYTHRRMAITGDDVSLDQIVPLSKDFMLEEVSPDGELYILGSDVTVQLNTAELKLVFQLPFGSHTRTFLQEVARACPGFDPETRDPEFEWLSRHTCAEPDAESPKPREWNSDPGTRSGFAPIGGSRHQSRNARRGLEDVLPRGPGYILLWGGAAEEPEFLLAEEMHEGGPVRGRRPLAGRRDEALEEADWEMSAGGGSRERDCAGVSNVDSSRPNGRGPDQPSGARCPEKPENSLTRQNKSKSDMSEKVRSATVTVSDKAHILSVQKFGLRDTIVRSHLVQKEENYTYIQNFRFFVGTYNVNGQSPKECLRPWLSHSALAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSESLHPDAKYAKVKFVRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQLHNTSICVVNSHLAAHTEEYERRNQDYRDICSRMQFPQVDPSQPPLTINKHDVILWLGDLNYRIEELDVGKVKKLVEEKAFQTLYAHDQLKIQVAARTIFDGFTEGEITFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNEELYRKTLEEIVRSLDKMENANIPSVTLSKREFCFENVKYMQLQTESFTIHNSQVPCQFEFINKPDEESYCKQWLTARPSKGFLLPDSHVEIELELFVNKSTATKLNSGKDTIEDILVLHLERGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLKTVSDLTLMSVQTADDRSQLENPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRPEFDHIRDCLDTGMIDQLCANNHSVAEALLLFLESLPEPVICYSAYHSCLECSGNYAASKQIILTLPSFHKNVFNYLMAFLQELLKNSANNHLDENILASIFGSLLLRNPARHQKLDMAEKKKAQEFIHQFLCGPL
What is the function of this protein?
Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
What are the official names of this protein?
Type II inositol 1,4,5-trisphosphate 5-phosphatase, Inositol polyphosphate-5-phosphatase B, Phosphoinositide 5-phosphatase, 5PTase.
What is the protein family that this protein belongs to?
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane.
Protein: AROQ_XYLFA
Sequence: MAHLLLLHGPNLNLLGTREPEIYGRITLPQIDAALAERATAAGHGLSSLQSNAEHVLIERIHATPEDGTAFILINPGAFTHTSVALRDALLAVALPFVEIHLSNPYTREPFRHHSYLADKALGVVCGFGVDSYRIALEGVIARLGSDV
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: ATPD_STAA2
Sequence: MVKVANKYAKALFDVSLDTNNLETINEELTVINEAVKDKIEQLKMVDSNPTQTAEQRRELINGVFTDINPYIKNMMYVLADNRHISLIADVFKAFQSLYNGHYNQDFATIESTYELSQEELDKIVKLVTQQTKLSKVIVDTKINPDLIGGFRVKVGTTVLDGSVRNDLVQLQRKFRRVN
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: G6PI_CALFI
Sequence: FTTQETITNANTAKQWFLKSAKDSKFVANHFVALSTNAKLVQEFGIDKANMFEFWDWVGGRYSLWSAIGMSIALNIGFENFEHLLSGAHWMDNHFKSTPIERNIPVILAVLGIWYGNFYGAETQALLPYDQYMHRFAAYFQQGDMESNGKYVVRAGDKVNYSTGPIVWGEPGTNGQHAFYQLIHQVPHHPCDFNSPVKSHNSELRDGLHHTILLSNFLAQTEALMKGKDRQTVEKELKAAGKSEDEIKSIGPHKEFTGNRPTNSIMVDTVTPFTLGAMIAMYEHKIFTQGIIWDINSYDQWGVE
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP110_ASHGO
Sequence: MFASLDTPAVHQRKKYEFTPIGHIKEKENMIAQELRQNKRPPLEDEEDAAIEGNYMKRTRVGDDTMNSQQLFNETSFDDTLPEQTLQGISAIKKNLAPELLSNDNKEKAELASNPLKEQQHALQKLNMENYSLRVKCNSLLKFLNNVTDDGKLKQGLEMLDELQEWKTKHHELIQRFKELQLRYDELEQREPEPLKVAEPADHSHCEKLRAELETSLKETRSQLDEVQATVSTLEKRLVEVKKDYSEKEHQYKMSLDIAKSENNRLTSSLSSREDALNEAQEKINRLMVQLEEFDHTSGSLLELEKKIDDKNQGIRNLETRLQELNFHRQDLERQLLTANETIEALKKEHEEYREQNELKLTSLHKNTSGEDRLRKQLRDLAEDKEGLQKLRQTLEERNKELDERVEALESQVAAIEEDRQKIIGEQQQVVRNLKLEHQKRAQNLKREIEELRELNQQLEETNRSYKKRFEHFSRNSPARKATQEELTAKDREIGALKRTIRDIEESVLRTTRELETAKIQHRREKSMLEARLDQAASEEPFERSRLEKEISMLKLEIRSIQDTKERELSLWESKYESLKNTYEKLLQQDKHSNLNEILEDRREELKSLMKKYNDLTTENLELTRELNKQKSHKEAYKEDLRKVQARLDFITKEFVKLKESAPEPKDSSDELNSKWMEKYQNMKIKLLNELKVLQDENIQLERRLLDRSQQQSHNLAETPTQSRDSSLQDKVDYYRLKYHDEVRKNNDLRVINEYLNRVLKASSQHLKLDILKLENEISPLNSSTTYINDYDYSYAPSYYSRRGRPLKFKTVAIFVLSCIRMYQATLRRRWDQQRINYLQRKIAYGEDRITW
What is the function of this protein?
Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.  Potential role in cross-linking filaments or anchoring other molecules.  It is essential for growth (By similarity).
What are the official names of this protein?
Spindle pole body component 110, Spindle pole body spacer protein SPC110.
What is the protein family that this protein belongs to?
Belongs to the SPC110 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Tightly associated with the nucleus. It is present in a granular pattern that excludes the nucleolus.
Protein: AP23_ORYSI
Sequence: MVLDLNVESPGGSAATSSSSTPPPPPDGGGGGYFRFDLLGGSPDEDGCSLPVMTRQLFPSPSAVVALAGDGSSTPPPTMPTPAAAGEGPWPRRAADLGVAQSQRSPAGGKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGLDADINFNLNDYEDDLKQMRNWTKEEFVHILRRQSTGFARGSSKYRGVTLHKCGRWEARMGQLLGKKYIYLGLFDSEIEAARAYDRAAIRFNGREAVTNFDPSSYDGDVLPETDNEVVDGDIIDLNLRISQPNVHELKSDGTLTGFQLNCDSPEASSSVVTQPISPQWPVLPQGTSMSQHPHLYASPCPGFFVNLREVPMEKRPELGPQSFPTSWSWQMQGSPLPLLPTAASSGFSTGTVADAARAPSSRPHPFPGHHQFYFPPTT
What is the function of this protein?
Probable transcription factor (By similarity).  Involved in spikelet transition.  Together with IDS1, controls synergistically inflorescence architecture and floral meristem establishment via the regulation of spatio-temporal expression of B- and E-function floral organ identity genes in the lodicules and of spikelet meristem genes.  Prevents lemma and palea elongation as well as grain growth.  Regulates the transition from spikelet meristem to floral meristem, spikelet meristem determinancy and the floral organ development (By similarity).
What are the official names of this protein?
APETALA2-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. AP2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARP6_DEBHA
Sequence: MSQQYFVIDNGSYNIKAGFSNQDAPIKHQNALSKARDGLIYVGNEYLVQTNNYSGMIFKRPYDHGHLISWETEKAVWDYTFNKASPNQELDASITHLTLTETPFQLPQLSMNTDQIVFEEYGFNEYYRCAPASLVPWSNLGSSESKNNDFTLVVDSGYSGTWIVPIIYQNVYWKGVKKLPIGGAALNGLLREIISFRHYDIADEPVLINTIKEKTCFMATDFEKSLANRKKYRCEFILPDFKTTTTGFVKTKDTPIDTTGDVQSLALIDERFTIPESFYHPEIIFDNTTSSTSTIQNASFKNITDLVVECIMSCPKVTQPLLSGNIITVGGNTNLPGFTDRLRHELVKELPIDWHVQVKETEHNPDEASWFGGAQLTNDEIINNISISKKDYFEHGSNWCQKQFGFKNL
What is the function of this protein?
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Involved in chromosome stability (By similarity).
What are the official names of this protein?
Actin-like protein ARP6.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Protein: DGTL1_SYNAS
Sequence: MTAREFLEATEKEKLAPYATRSADSAGRTLHGDEPDDYRTCFQRDRDRILYSKVFKDLQHKTQVFLINEGDFYRTRLTHTLEVAQHARTFARALRLNEDLCEAIAYAHDLGHPPFGHSGEETLNDLLKDDGGFEHNIQSLRVVDFLEKRYQRYDGLNLCFETREGIARHNTTHDHPDTPPEFQNYSQASLEAQVVNIADPLAYCAHDLEDALNAGYLRMKDLRNMENPLVRRVFERCSSRYPDFLKADTVLQSRILVRTLIEEANIAVIRQTSRNIELYGISSVEEARSLPEDVVAAPAGVWKNFDALKAYLFENVYRKPQVCIMNEKGKLIIRRIFHHLEKRPEMLPGIFKTRFDEAADSSGKRRVLADYISGMTDRYVMDLYMMMFEPYEKVMFEFRE
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: SYY_IDILO
Sequence: MKTEVAEAIAEITRGAEEVLLEQELAEKLASGKPLTVKAGFDPTAPDLHLGHTVLINKLRVFQDFGHKVVFLIGDFTGMIGDPTGKNVTRKPLTTEQVIANAETYKEQVFKILDPAKTEIRFNSEWMSKMGAADMIKLAARQTVARMLERDDFKKRYQNNQSIAIHEFLYPLVQGWDSVELKADVELGGTDQRFNLLMGRELQKEEGQRPQTVIMTPLLEGLDGVQKMSKSLNNYIGITEPANDMFGKIMSVSDELMWRYFQLLSFRSITEIDELKAAVADGKNPRDVKVLLAKEIIARFHSEDDAEKAEQDFIQRFQKNALPDDIPEKTVQVGAEGMAIGNVLKEAGLVESTSEALRMIKQNAVKVDGEKFSDSRYLCTEKDSGVYQVGKRRFAKINLTA
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAP1_ECOL6
Sequence: MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).  Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Protein: Y2158_STAAN
Sequence: MKRLVTGLLALSLFLAACGQDSDQQKDSNKEKDDKAKTEQQDKKTNDSSKDKKDNKDDSKDVNKDNKDNSANDNQQQSNSNATNNDQNQTNNNQSSNNQKSSYVAPYYGQNAAPVARQIYPFNGNKTQALQQLPNFQTALNAANNEANKFGSNNKVYNDYSIEEHNGNYKYVFSFKDPNANGKYSIVTVDYTGQAMVTDPNYQQ
What are the official names of this protein?
Uncharacterized lipoprotein SA2158.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GPSB_STRPI
Sequence: MSSIIFSAKDIFEQEFGREVRGYSKVEVDEFLDDVIKDYETYAALVKSLRQEIADLKEELARKPQVSSAPSPSHPDPIDVAASSSMTNFDILKRLNRLEKEVFGKQILDNPDL
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: YL243_MIMIV
Sequence: MAIASQSLSVNQMYEKLLQNGEVESNSPKNRLRLYHLLQSKKIPFETKIIGYTSGEKSLSRWSGRRMGWDLGRVVKWIESGRLTREELQRCCDLFNQSNCKPRAELSDIENVFNKELNREQKCQLIKNNWDKILDDKWTPFDYCMLKKTIVRITLVK
What are the official names of this protein?
Uncharacterized protein L243.
What is the protein family that this protein belongs to?
Belongs to the mimivirus L242/L243 family.
Protein: TRUD_ECO81
Sequence: MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKVLMITAVLPGSGEWGTQREALAFEQAAVAEETELQTLLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: SYFB_BORAP
Sequence: MPKVEIYKNLFLDKVGKNFTNSEISELLEPFKAEFDGFDENSGKIKIEFNDTNRPDLWSYTGLARQIKTYFFGKIPCYDFFSKKGDFKKCYGEILVDNKMSQIRPFIFGFLAKGLIINDRMLEALIQFQEKLCQSYGQKRKRVAMGMYNSNFIKFPISYVASSPNHKFVPLGMDCELSLLEINEKHPKGLEYSHIIKNFDKYPLLLDDNNNVVSYPPIINSNNIGSLKVGDTDIFVEVTGIDFEATLLALSVVACDFYDMGFEILPVKTVFKKPFGLDFEELVCPYYFQEEVEFNVKNVNRLLGSNLTLERICLSLKKMGVNSYSRDLKNYVIPPFYRNDFLHEVDVIEDVMIGEGLASFHPELPKAFAVGRLSALEEFSRDIRNLMVGMGFQEMIYNYMGSKKDFIDRMNISDQNFLKVSNPMTENYEYIRASIIPNLLKSESVSSNFPYPHKIFEVGKIALKNLNTTIEGTNTFTNLAFLMSGKEISFNEINSIVATLFYYLNIEINLKESQANFYINGRGADIFLKDFNIGSFGEISPYVLNNFGIFIPCSVFEVNINKLMSRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_MYCVP
Sequence: MSQISRDEVAHLARLARLALTDSELDSFAGQLDAILGHVGQIQTVDVTGVEATGNPLKDVNVFRPDVEAPSLTQEQALAAAPNTDEGRFAVPRILGEAE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: CYB_GALCU
Sequence: MAINIRKTHPLLKIINHTLIDLPAPSNISLWWNFGSLLGLCLIIQILTGLFLAMHYTADISMAFSSVVHICRDVNYGWLIRNIHANGASLFFICIYLHIARGLYYGSYLYKETWNIGVILLFLLMATAFVGYVLPWGQMSFWGATVITNLLSAFPYVGNTLVQWIWGGFSVDNATLTRFFAFHFLLPFLILALTIIHLLFLHETGSNNPLGINSDMDKISFHPYMSYKDILGFFAMIFFLAVLTLFIPNLLGDAENFIPANPLVTPPHIKPEWYLLFAYAIFRSIPNKLGGVLALLFSILILMLVPLLQTSKQRSTIFRPMTQILFWFLVANSIILTWIGGQPVEQPFIMVGQIASISYFSMFLIIIPFASWCENKILSLN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MPAG_PENBR
Sequence: MSAASPASIIQELASAAKQYENNESGAREALIAQSRALIASLEVPSEFIQHTFWSQPALSAIVRLATDVNLFQYLKDAQEEGLSAEALASKTGMDVSLFARLARHLVAMNVITSRNGVFYGTALSNGLAAENYQQSIRFCHDVSRPSFGAFPSFFKGNGYKTPALGTTDGPFQSAHKVDISFPQWLVGNPPYLQYFNSYMSAYRAGKPNWCDNGFYPVADRLLNGFDASVSDVLLVDVGGGRGHDIATFGSQFSPLPGRLVLQDREQVINSIPADESRQFEATTHDIFTTQPVKNARAYYMHSVPHGFGDEDAVKIMANLVPALAKGYSRVLLNEIVVDEESPVMSATNMDLIMLAHMGAKERTEADWRSILTRAGLKVVNIYSYPGVAESLIEAELA
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (PubMed:25630520).  MpaG methylates farnesyl-DHMP-3C (FDHMP-3C) to yield MFDHMP-3C (PubMed:25630520).  The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC.  5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE.  MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB).  MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP.  The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP).  The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate.  The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C.  After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight.  Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps.  The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process.  Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (PubMed:21398490, PubMed:22544261) (Probable).
What are the official names of this protein?
O-methyltransferase mpaG, Mycophenolic acid biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PTP1_NPVOP
Sequence: MLTSRRWAVIYTRTSERNCGGAWCTNGVRRRRQVHLPSVRARAMFPDRWHEYTACGAVIEGTRLLCFKVPLNAELFEYVTSDEDRWTAASVLARHSALGAVIDLTNTARYYDGAQMVKMGLLYKKIRVPGRAVPDDDIVAEFIETVDEFFRRCPTMLVAVHWTHGLNRSGYLVCRYMVERLGVSPTDAIARFETARGHKIERTNYLQDLLARKHVRGQPN
What is the function of this protein?
Could be inactive as the active site cysteine is modified to tryptophan.
What are the official names of this protein?
Putative tyrosine-protein phosphatase 1, Protein-tyrosine phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Protein: I2BPL_RAT
Sequence: MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRAHGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAQQQQQQQQQQQQQQQQQPQQLNHVDGSTKPAVLPAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSLGSSSHAARLPNGLGGPNGFPKPAPEEGPPELNRQSPNSSSAATSVASRRGTHSGLVTGLPNPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPHGLGGSRGPPTPAPPGAPGGPACLGGPPGVSATVSSAPSSTSSTVAEVGVGAAGKRPGSVSSTDQERELKEKQRNAEALAELSESLRNRAEEWANKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPTGRGAAASLRKRKASPEPPDSAESALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPPPPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSPVSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDP
What is the function of this protein?
Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins.  Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway.  Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity).  Also acts as a transcriptional regulator of genes controlling female reproductive function.  May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase IRF2BPL, Enhanced at puberty protein 1, Interferon regulatory factor 2-binding protein-like, Polyglutamine-containing protein.
What is the protein family that this protein belongs to?
Belongs to the IRF2BP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: 1A1D_BURPS
Sequence: MNLQKFSRYPLTFGPTPIQPLKRLSAHLGGKVELYAKRDDCNSGLAFGGNKTRKLEYLIPDALAQGCDTLVSIGGIQSNQTRQVAAVAAHLGMKCVLVQENWVNYHDAVYDRVGNIQMSRMMGADVRLVPDGFDIGFRKSWEDALADVRARGGKPYAIPAGCSDHPLGGLGFVGFAEEVRAQEAELGFQFDYVVVCSVTGSTQAGMVVGFAADGRADRVIGVDASAKPAQTREQILRIAKHTADRVELGRDITSADVVLDERFGGPEYGLPNEGTLEAIRLCAKLEGVLTDPVYEGKSMHGMIEKVRLGEFPAGSKVLYAHLGGVPALNAYSFLFRDG
What is the function of this protein?
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate.  Allows growth on ACC as a nitrogen source.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate deaminase, ACC deaminase, ACCD.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: UXUA_YERPP
Sequence: MEQTWRWYGPNDPVSLDDIRQAGATGVVTALHHIPNGVVWPVSEIKQRQAELAAKNLVWSVVESVPIHEDIKTHSGNYQQYIENYQQTLRNIAECGIDTVCYNFMPILDWTRTDLEYELPDGSKALRFDQIAFAAFELHILKRPGASNDYTAEEQVQAEAYFNAMTEADIAKLTGNIIAGLPGAEEGYTLDQFRARLAEYDGIDKAQLRENMAYFLRAIIPVAEQVGLRMAVHPDDPPRPILGLPRIVSTIEDMQWLKETVDSIHNGFTMCTGSYGVRADNDLVKMIETFGDRIHFTHLRSTCREGNPKTFHEGGHLQGDVDMYSVVKAILTEEQRRQSLGDMRPIPMRPDHGHQMLDDLHKKTNPGYSAIGRLKGLAEVRGVELALKRTFFPELKQ
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: YBHB_ECOLI
Sequence: MKLISNDLRDGDKLPHRHVFNGMGYDGDNISPHLAWDDVPAGTKSFVVTCYDPDAPTGSGWWHWVVVNLPADTRVLPQGFGSGLVAMPDGVLQTRTDFGKTGYDGAAPPKGETHRYIFTVHALDIERIDVDEGASGAMVGFNVHFHSLASASITAMFS
What are the official names of this protein?
UPF0098 protein YbhB.
What is the protein family that this protein belongs to?
Belongs to the UPF0098 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS27_PYRHO
Sequence: MSLPRNVIPMPRSRFLRVKCIDCGNEQIVFSHPATRVRCLVCGATLVEPTGGKGIVKAKILEVLE
What are the official names of this protein?
30S ribosomal protein S27e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS27 family.
Protein: RF298_ARATH
Sequence: MVEKQEEMNEFGAVNGGKVGTSSSVSPPQDKGRKNKRKLADPSPQNAASLTEFPRYELHSFKSQSPLCENDSNGQLKAEESDSVGWDDPFACHLEGLLSSNLLTLFRSAMNQIMDCGYSEDVVLKAISSSRFYCGGTDLVSNIVNDTLSFLKSGKKVAGSRDYVFEDLQQLVAYSLVEKISLVREVRPSLSTDEAMWRLLICDLNVLKAFEVDADGLEGSSVSNASKSSESPVAECNPPKSSDADNPKAPVSNTQSKQSEPVKFGNFANVNNSKNPHASGATPGKEVFSVSTASGEGTKSASLTSVSDEKLVSCRKGRTKKEMAMLRQKSCVEKIRTYSKGGGYKTAKFGGFLVEKRGKSASDLLSAQARNSSSKITTEVMKIPLAESSSTLSNSTKSDSPALDVKEHVTALPANNAPAPVASEKKSGSEPEEKPSVSTKPAPDYYAAIPYDATLGIYIPRNKRDELILKLVPRMKDLQKELQDWTDWANQKVKQATVRLLKDQPELKALRKEKEEAEEFRKEKQLLEENTIKRRSEMELALNNATNQLERTNNTIRRLELEQSLLKREREAANIRASESAESCREAKERVQRLLKNSQSWEGQKNLLQEELKSQRDKVAGLQQEVAKAKTRQNQIEATWKQEKSATGKLTAQAAALKKERGKLEELGKAEEERIKTKAENDVKYYIENIKRLDTEISKLKLKSDSLKIAALKKGIDGNNDGNKSGMNHTTNTKANSMASAKVWENNQGAESKIKRERECVMCLSEEMSVIFLPCAHQVLCSKCNQLHEKEAMEDCPSCRAKIQRRIQARFARG
What are the official names of this protein?
Putative E3 ubiquitin-protein ligase RF298, RING finger protein 298, RING-type E3 ubiquitin transferase RF298.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family.