PharMolix/UniProtQA huggingface dataset:
Protein: GP_TSWV1
Sequence: MRILKLLELVVKVSLFTIALSSVLLAFLIFRATDAKVEIIRGDHPEIYDDSAENEVPTAASIQREAILETLTNLMLESRTPGTRQIREEKSTIPISAEPTTQKTISVLDLPNNCLNASSLKCEIKGISTYNVYYQVENNGVIYSCVSDSAEGLEKCDNSLNLPKRFSKVPVIPITKLDKKRHFSVGGKFFISESLTQDNYPITYNSYPTNGTVSLQTVKLSGDCKITKSNFANPYTVSITSPEKIMGYLIKKPGENVEHKVISFSGSASITFTEEMLDGEHNLLCGDKSAKIPKTNKRVRDCIIKYSKSIYKQTACINFSWIRLILIALLIYFPIRWLVNKTTKPLFLWYDLMGLITYPVLLLINCLWKYFPLKCSNCGNLCIVTHECTKVCICNKSKASKEHSSECPILSKEADHDYNKHKWTSMEWFHLIVNTKLSLSLLKFVTEILIGLVILSQMPMSMAQTTQCLSGCFYVPGCPFLVTSKFEKCSEKDQCYCNVKEDKIIESIFGTNIVIEGPNDCIENQNCIARPSIDNLIKCRLGCEYLDLFRNKPLYNGFSDYTGSSLGLTSVGLYEAKRLRNGIIDSYNRQGKISGMVAGDSLNKNETSIPENILPRQSLIFDSVVDGKYRYMIEQSLLGGGGTIFMLNDKTSETAKKFVIYIKSVGIHYEVSEKYTTAPIQSTHTDFYSTCTGNCDTCRKNQALTGFQDFCVTPTSYWGCEEAWCFAINEGATCGFCRNIYDMDKSYRIYSVLKSTIVADVCISGILGGQCSRITEEVPYENTLFQADIQADLHNDGITIGELIAHGPDSHIYSGNIANLNDPVKMFGHPQLTHDGVPIFTKKTLEGDDMSWDCAAIGKKSVTIKTCGYDTYRFRSGLEQISDIPVSFKDFSSFFLAKSFSLGKLKMVVDLPSDLFKVAPKKPSITSTSLNCNGCLLCGQGLSCLLEFFSDLTFSTAISIDACSLSTYQLAVKKGSNKYNITMFCSANPDKKKMTLYPEGNPDISVEVLVNNVIVEEPENIIDQNDEYAHEEQQYNSDSSAWGFWDYIKSPFNFIASYFGSFFDTIRVVLLIAFIFLVTYFCSILTSICKGYVKNESYKSRSKIEDDDEPEIKAPMLMKDTMTRRRPPMDFSHLV
What is the function of this protein?
Forms the spikes present at the surface of the virion together with Glycoprotein N.  They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).  Probable class II fusion protein (PubMed:33672327).
What are the official names of this protein?
Envelopment polyprotein, M polyprotein.
What is the protein family that this protein belongs to?
Belongs to the tospovirus envelope glycoprotein family.
What are the subcellular locations of this protein?
[Glycoprotein N]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Glycoprotein C alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of Glycoprotein C and Glycoprotein N results in efficient transport of Glycoprotein C to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs. SUBCELLULAR LOCATION: [Glycoprotein C]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=Glycoprotein G2 is retained in the Golgi complex and probably contains a Golgi retention signal.
Protein: Y157_AFV1Y
Sequence: MSEMSVVEYEVVSKNLTSKMSHELLFSVKKRWFVKPFRHDRQLGKLHYKLLPGNYIKFGLYVLKNQDYARFEIAWVHVDKDGKIEERTVYSIETYWHIFIDIENDLNCPYVLAKFIEMRPEFHKTAWVEESNYSIAEDDIQMVESIKRYLERKIASD
What are the official names of this protein?
Uncharacterized protein ORF157.
Protein: UBIA_YERPP
Sequence: MKGSTVHTKWQAYCRLMRIDKPIGSLLLLWPTLWALWLAGRGIPEAKILVVFVLGVFFMRAAGCVVNDYADRHIDGFVKRTASRPLPSGTISEKESKILFVVLILLSFGLVLTLNSMTIWLSLAALALAWIYPFMKRVTHLPQVVLGAAFGWSIPMGFAAVSESLPLVCWLLLLANICWTVAYDTQYAMVDRDDDLRIGVKSTAILFGQHDKLIIGLLQLATLLLMVAIGWLMNLGGAFYWSILLAGALFTHQQKMIAQREREPCFRAFLNNNYVGLVLFLGILISYW
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPEE_ECOL6
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAVHTAAFALPQYLQDALASQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH4_METFK
Sequence: MNQPSIPPIEDVQNTPDTRQLAIDKVGIKSIRHPVKVKDKTGGVQHTVATFNMYVYLPHNFKGTHMSRFVEILNNNEREISVESFESILRAMVERLDAESGHVEMTFPYFVNKTAPVSGVQSLSDYEVTFIGEINKGKYDITVKVVVPVTSLCPCSKKISDYGAHNQRSHVTVTALINDFIWVEDIIRMVEDQASCEVYGLLKRPDEKYVTERAYDNPKFVEDIVRDVAAQLNIETRIVSYTVESENFESIHNHSAYALIEKDKRK
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RL332_MYCTO
Sequence: MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLELKKFCPNCGKHQAHRETR
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RS7_MYCAP
Sequence: MSRKHSAPIRKVLADPVFNSVLVTKLINAIMLDGKKSLAQDILYSAFNLVKEKTQKDPMEVFQAAIDNVTPQLEVRTRRIGGTNYQVPTEVSARRKQTLALRWLVQYARLRNEKTMDVRLANEIIDASNKTGGAIKKREDTHKMAEANRAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: LUXS_CAMHC
Sequence: MPLLDSFKVDHTKMKAPGVRLAKVMQTPKGDNISVFDLRFCRPNHEIMSEKGTHTLEHLFAGFMREHLNSKDVEIIDISPMGCRTGFYMSLIGRPSETEVIKAFENSMKDVLKVTSQDDIPELNKFQCGSYKMHSLSEAKEIAQNVLNKGICIIKNDEIKLENF
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: GGT2_SCHPO
Sequence: MSPTDTTPLLYSWDDQSRHQDPDWHKLRNYHGAWYRRISRRRFSQFIFAFGLMTLFVLVYSISSNLHTPTQFTGHKVRGRRGAVASEVPVCSDIGVSMLADGGNAVDAAIASTFCIGVVNFFSSGIGGGGFMLIKHPNETAQSLTFREIAPGNVSKHMFDKNPMLAQVGPLSIAIPGELAGLYEAWKSHGLLDWSKLLEPNVKLAREGFPVTRAMERVLKLPEMAHLLKDPIWQPILMPNGKVLRAGDKMFRPAYAKTLEIIANKGIEPFYRGELTNSMVKFIQDNGGIVTVEDFGNYSTVFADALHTSYRGHDVYTCTLPTSGPALIEGLNILDGYPLNTPSLAFPKRLHLEVEAMKWLSAGRTQFGDPDFLPLDHLDVVSKLLSKEFASQIRNNISLSKTYPWEHYNPSYDLPISHGTTHVSTVDSNNLAVSITSTVNLLFGSQLMDPVTGVVFNDQMDDFSIPGASNAFNLSPSPWNFIEPFKRPQSSSAPTILTDINGDFEMALGASGGSRIVTAVLDSIIKRIDMDYDIESMVASARPHHQLLPDILILESGFSKSVATRMKKYGHKVWRLKQHDTPLSQIQAVTRHHSEYYGMSDPRKYGQAAAY
What is the function of this protein?
Catalyzes the transfer of the gamma-glutamyl moiety of glutathione (GSH) and other gamma-glutamyl compounds to amino acids and peptides.  Major GSH-degrading enzyme, catalyzing the hydrolytic release of L-glutamate from GSH.  Plays a role in the turnover of the vacuolar GSH, serving as an alternative nitrogen source during nitrogen starvation (By similarity).
What are the official names of this protein?
Glutathione hydrolase proenzyme 2, Gamma-glutamyltransferase 2, Gamma-glutamyltranspeptidase 2.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyltransferase family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein.
Protein: CIDB_STAAC
Sequence: MNDYVQALLMILLTVVLYYFAKRLQQKYPNPFLNPALIASLGIIFVLLIFGISYNGYMKGGSWINHILNATVVCLAYPLYKNREKIKDNVSIIFASVLTGVMLNFMLVFLTLKAFGYSKDVIVTLLPRSITAAVGIEVSHELGGTDTMTVLFIITTGLIGSILGSMLLRFGRFESSIAKGLTYGNASHAFGTAKALEMDIESGAFSSIGMILTAVISSVLIPVLILLFY
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).
What are the official names of this protein?
Holin-like protein CidB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. CidB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CSOS2_PARMW
Sequence: MARLSSRELALERRKALTTSGKKSSVAAGDGANRVRTASDVRPTRTDAAAAVEPTAPAVSAPVKPTVSFTPASPSSSSHVKPQRHPSRDLVLARRDALSRRGKTADTSRDRNRADVARQTQAAAPVAASAEEQKTCGCGGKRAAGKVQLSAPTTSLKPRSDRRSAAPKRRAIENPSRALVLARREAMAKHGKTAGKQPTSAAAVARQANPDLTSRELAQQVRELRTKAGARNKQSAGATRPTGPNRHGAKQAAAADAHWKVGESTTSTGQTVTGTQANRSVKTTGNEASTCRSITGTEYLGAEVFQTFCQQAPEPTTPAKVRVTATSHGNRVTGNEVGRSEKVTGDEPGTCKSVTGTEYISANQSAAYCGSSQVSQRKVGHSLTQQGRPVSGVMVGRSSSVTGDEAGAGRSLTGDQYLGSDPLPDGRPAAKVGQSGTLSGTGVTGTLVGRSSQVTGNEFGSCHRVTGDQYISAEQVNAFCGSKPEPEAAKVGFSITNRNQVVSGTRTGRSERVTGDEPGTCKAVTGTPYAGLENAGQHCGTSAVQAIRERTPVRLGTPSAAMTGIQPGVGGVMTGDEKGACEAVTGTPYVGADQLATACGNEAPAGTDSHGQAPEGAAWTRFSVMSPARAAQQQRDDQGAVTGTSYEQGNRITGPFDLAGGKVTGTEQFRFDNREFQRRQFQPTVAVVSEPAEQPASRVTGEGSSTKITGDDWDRGEHVTGTEGVSARRRNPTRPGPMSATVPHERKRNEENEWPVSRVTGSSGNTEKGSLITVSGGARG
What is the function of this protein?
Required for alpha-carboxysome (Cb) assembly, mediates interaction between RuBisCO and the carboxysome shell.  The protein is probably intrinsically disordered.  The C-terminal repeats act as the encapsulation signal to target proteins to the Cb; they are necessary and sufficient to target both CsoS2 and foreign proteins to the Cb.  The N-terminal repeats of this protein bind simultaneously to both subunits of RuBisCO.  Probably also interacts with the major shell proteins (CsoS1); that interaction would increase the local concentration of CsoS2 so that it can condense RuBisCO and full carboxysomes can be formed.
What are the official names of this protein?
Carboxysome assembly protein CsoS2, Carboxysome shell protein CsoS2.
What is the protein family that this protein belongs to?
Belongs to the CsoS2 family.
Protein: LH2_ADES1
Sequence: MKVQRMAYEMGRYISEEDLAKLIAETSGYPWRWWQQPTLLTPRLWKTLEMLNQIKVHTTKYHNELNRLLKTGKFISDLQLACQAVPRPLTIALFCTLLLWAAEYSFCGEKEETWARCKSAAKVLYSLLQDRV
What are the official names of this protein?
Protein LH2.
Protein: LIPA_YEAS7
Sequence: MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAKKLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: METN2_ALKCK
Sequence: MIEASELTKVYKTKKKRVIGVDNVSFKVGKGEIFGIVGYSGAGKSSLLRCINLLERPTSGTIRVDGLDLTKLGTRELRQARLKIGMIFQHFYLINQKTVFGNIAFALKAAGVRADLIPARVEELLELVGLSNKRNAYPAQLSGGQKQRVGIARALANKPSVLLCDEATSALDPTTTKSILALLKKLNEELGLTIVLITHEMAVVKEICHKMAIMQDGKMIEQGDVYDVFAAPKAPLTQEFIGDVVSFHIPEHTLSQFSGTIAKVIFKGSVAQQGIISDTLQQFSVKGNFLHGAIEYIGGRPLGIFIMELKGEPTAIQEAIAYIKQRSAEVEVIRDGLRAFS
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL27_CAUVN
Sequence: MAHKKSGGSSSNGRDSESKRLGVKKFGGEKVLAGNILVRQRGTKFYPGSGVGIGKDHTLFALVQGAVGFVTKKHNRTYVTVTPAAQPAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: DEF4_RAPSA
Sequence: MAKFVSIITLLFVALVLFAAFEAPTMVEAQKLCERSSGTWSGVCGNNNACKNQCINLEGARHGSCNYIFPYHRCICYFPC
What is the function of this protein?
Possesses antifungal activity sensitive to inorganic cations.
What are the official names of this protein?
Defensin-like protein 4, Cysteine-rich antifungal protein 4, AFP4.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS10_CHESB
Sequence: MNGQNIRIRLKAFDHRVLDASTREIVSTAKRTGANVRGPIPLPTRIEKFTVNRSTHIDKKSREQFEMRTHKRLLDIVDPTPQTVDALMKLDLAAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: EIF3L_ANOGA
Sequence: MYSNEEPWEGGYDEYGYEMGMPEDGMYDRGYFPMHEDVKKFLMYFCTVIKDGVVYEIQNLYENTFPKLSEQHFEKKAWPSEEEVAHLVDNDNLFLILYKELYYRHLHARIQGGPSLEQRLNSFYNYCNFFNYILPSKEPVQLELPDIWLWELIDEFVYQFQNFAQYRARLTDKTDEEMDMLLNNNSKVWNILCILNVLHSLVSMSKIKDQLEAAAAGKDPEAVAGEFGRHSFYKMLGYFSLVGLLRVHSLLGDYHQAIKVLEPIEIHKKSQYSHIPSCQISTSYYVGFAYMMMRRYSDAIRTFSSILLYIQRTKQLYSARSYQNDQINKQTDQMYHLLAICLVLHPQCIDESIQQVLREKNYHDNMYKMQCGDLDVFRNFFVFACPKFVSPVPPPPDAPIEDYVKDALEHQINVFMDEVKQQQELPTIRSYLKLYTTLPIMKLASFMDRKPQDEVDEQKLENLLTRLLCFKHKMKNVVWTKGSSGLEGKFQSGSELDFYIDKDMIHIADTKVSHRYGDFFIRKVMKFEDLNRRLHAIKG
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHK1_STRVN
Sequence: MTTATATATATPGTAAKPVALVTGATSGIGLAIARRLAALGARTFLCARDEERLAQTVKELRGEGFDVDGTVCDVADPAQIRAYVAAAVQRYGTVDILVNNAGRSGGGATAEIADELWLDVITTNLTSVFLMTKEVLNAGGMLAKKRGRIINIASTGGKQGVVHAVPYSASKHGVVGLTKALGLELARTGITVNAVCPGFVETPMAERVREHYAGIWQVSEEETFDRITNRVPLGRYVETREVAAMVEYLVADDAAAVTAQALNVCGGLGNY
What are the official names of this protein?
Granaticin polyketide synthase putative ketoacyl reductase 1, ORF5.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RF1_SOLUE
Sequence: MQFAQKLDQLEKRFDELTQQMADPAVISDADQYRKVAKAQSELSDIAAKYREWKKVEDGLAQARPMLQEQDAELKEMAELEIAQLEPEKLRIEEELRVLLLPKDPNDDKNVVLEIRAGTGGDEATLFAAEIFRMYSRYAETQNWKMEVTSSSESSVGGLKEVIALVSGNKVYAKLKYESGVHRVQRVPVTEQQGRVHTSAITVAVLPEADEVEVKLEAKDIRIDTFCSSGPGGQSVNTTYSAVRITHLPTGLVVSCQDEKSQIKNRAKAERVLRSRLYELELEKQQAALGAERRTMVGSGDRSEKIRTYNFPQNRVSDHRIGLTLHQLDFVMEGKMDAIVDALTEFYQAQKLKQQAEKGPVS
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEPA_EHV1V
Sequence: MLCRRGSDYTAEFCHVPVSGELLKRGARDASLVTPARVASAAQTAAVPGCWPLAPLGNAMLWKSVYGGITAALKRAVGSFAFYQPLVLGINTQTGLLVTLRPAASAGEGGGDHVSPRAAIVNVSVEVDLDPAGIEASAASSTGSSLARARLCTLRDGYFLSKRDIALEVEIATKEVSFYRKYDSVQQPANKRRGDMADLFVVHERTLLLGGCKRMGVKVLLPRTFDCLVASSQSVSGLAAMALYKQWHATLFSVELPDTVVQIFAYLGPELNPCGEEVDYCCFVGFPGLPTLKASSSTTEAVRDAMAAYRLSDGLWPALGMSAFHFLAPWDPEDRWPGESEAKRVEGAVHRLQLGTEDDWGAGRVSCILESDAVMQGPWFAKFDFSAFFPTLYLLLFPANERLAEVVRLRARGQHPTLKLALVSFFGGLQHINPVAYRSIIALSNGISKRLEHEVNQRGFAICTYVKDGFWGAAGNLPSDSVSYADALVYAEELRSAAQKAALGHVSEMGFSLPEGVHLNLRLEGLFTDAISWSTHCYWLYNRFTKMEDFVGFPAKSGAGRAAKASLSALLPLVAAVCDSSDMSTLHQSVRGACEQLVAGAFAERNNPQFWSTRTGIESSTLLPPAVYRNGSLLDRDCGQREIVLTRKHDCESPSPVPWTLFPPPLVLGRIDCMVYLTSIFKTYLSMLNRAISASCDADESMNVDFPISDYAFLFT
What is the function of this protein?
Component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs.  The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
What are the official names of this protein?
DNA helicase/primase complex-associated protein, HEPA, Primase-associated factor.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HEPA family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: VPS36_HUMAN
Sequence: MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDAGTLLLSTHRLIWRDQKNHECCMAILLSQIVFIEEQAAGIGKSAKIVVHLHPAPPNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVSQSLQTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMIKAKEMVELSKSIANKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQVPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLPLRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQS
What is the function of this protein?
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.  The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation.  The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.  Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes.  The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL.  Binds phosphoinosides such as PtdIns(3,4,5)P3.
What are the official names of this protein?
Vacuolar protein-sorting-associated protein 36, ELL-associated protein of 45 kDa, ESCRT-II complex subunit VPS36.
What is the protein family that this protein belongs to?
Belongs to the VPS36 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
Protein: YOP1_DEBHA
Sequence: MSYQNQAKSFLSTIDEKTKDLQILRQFELKTGLPRSYAILGGFGLYFVLIFLNIGGVGQLLSNIAGLVIPGYFSLLALESTTTSDDTQLLTYWVVFATFNVVEFWSKAILYWIPFYYLFKTVFLVYIGIPSTGGAVTVYNAAIKPFSRRYIVNNKKFAQDINNAAQGVSSSVELLAS
What is the function of this protein?
Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole.  Induces high curvature in membranes and causes membrane tubule formation.  Involved in membrane/vesicle trafficking.
What are the official names of this protein?
Protein YOP1.
What is the protein family that this protein belongs to?
Belongs to the DP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: PYRH_PROMM
Sequence: MAYARVLLKLSGEALMGDQSYGIDPAIVQSIAEDVAKVVAKGTQLAIVVGGGNIFRGLKGSAAGMDRATADYVGMLATVMNAITLQDGLERAGVPTRVQTAIEMQEVAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTASLRAAEINADVVFKATKVDGVYDRDPKRFPDATRYDSLTFQQVLSGELAVMDSTAIALCKDNNIPIVVFDLFEPGNIGKAVAGEAIGSRISNAT
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_ENT38
Sequence: MSRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRVSAKGMRVIDKKGIDTVLSELRARGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RNY_SYNAS
Sequence: MLNYTVIAFIMLGLIAIGLAIGYFLKFRLSQKRLESSENLALRIIDEAKKEAETIKKEAVLQTKENLLKLKAEFEKETRERKLDLDNLERRIRSKEENLDKRIDSMSQKENAIEVREKNLLSKEMQLNEKHDKLSRMIGEQKEKLEQIADITSEEAKDFLIRSMEAAAKRDAAMLIRKIEEDAKREADKKSREIIAYAVQRYAGDYVAENTVSVVNLPNDEMKGRIIGREGRNIRAIEAATGIDLIVDDTPEAVVLSSFDPIRREVAKISLERLITDGRIHPGRIEDIVKKVRLEVDSIIKETGERVSFDVGVHDIHPELINLLGSLKYRTSYSQNVLQHSIDVAHLTGMMAAELKMNIKEAKRAGLLHDIGKAVDHKIEGTHAAIGADYAKRFGESQRIVQAIAAHHDDGRTNTLLGVLVQAADTLSAARPGARREMLETYVKRLEELENIANSFNGVDKCFAIQAGREIRILVGSEKLSDNDAMMLCKDIVKKIESELTYPGQIKVTVIRETRVSDFAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL9_NEIG1
Sequence: MQIILLEKIGGLGNLGDIVTVKNGYARNFLIPAGKAKRATEANMKEFEARRAELEAKQAEILADARARQEKLDGQTVTVAQKAGVDGRLFGSVTNADIAAAIVAAGIEAVKANVRLPNGPLKAVGEYEVEVALHTDAVAKITVAVIAAAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.