PharMolix/UniProtQA huggingface dataset:
Protein: PLXA2_HUMAN
Sequence: MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES
What is the function of this protein?
Coreceptor for SEMA3A and SEMA6A.  Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton.  Plays a role in axon guidance, invasive growth and cell migration.  Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin.  The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
What are the official names of this protein?
Plexin-A2, Semaphorin receptor OCT.
What is the protein family that this protein belongs to?
Belongs to the plexin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SYY_GEOKA
Sequence: MDLLAELQWRGLVNQTTDEDGLRKLLNEERVTLYCGFDPTADSLHIGNLAAILTLRRFQQAGHRPIALVGGATGLIGDPSGKKSERTLNAKETVEAWSARIKEQLGRFLDFEADGNPAKIKNNYDWIGPLDVITFLRDVGKHFSVNYMMAKESVQSRIETGISFTEFSYMMLQAYDFLRLYETEGCRLQIGGSDQWGNITAGLELIRKTKGEARAFGLTIPLVTKADGTKFGKTESGTIWLDKEKTSPYEFYQFWINTDDRDVIRYLKYFTFLSKEEIEALEQELREAPEKRAAQKALAEEVTKLVHGEEALRQAIRISEALFSGDIANLTAAEIEQGFKDVPSFVHEGGDVPLVELLVSAGISPSKRQAREDIQSGAIYVNGERLQDVGAILTAEHRLEGRFTVIRRGKKKYYLIRYA
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CKL_CONLY
Sequence: MQLYTYLYLLVPLVTFHLILGTGTLDHGGALTERRSTDAIALKPEPVLLQKSSARSTDDNGNDRLTQMKRILKKRGNKARGEEEVAKMAAELAREDAVNGK
What is the function of this protein?
Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors.  This toxin is far less potent as an anticonvulsant compound than conantokin-R.  It induces sleep-like symptoms in mice.
What are the official names of this protein?
Conantokin-L, Con-L.
What is the protein family that this protein belongs to?
Belongs to the conotoxin B superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YCF3_LOLPR
Sequence: MPRSRANGNFIDKTSSIVANILLRIIPTTSGEKKAFTYYRDGMLAQSEGNYAEALQNYYEATRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAILQGDSEIAEAWFDQAAEYWKQAIALTPGNYIEAQNWLKITKRFEFE
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: SYE_BORPD
Sequence: MTSTPATIRTRFAPSPTGFLHLGGARTALFSWAFARHHQGVFVLRIEDTDLERSTPEAVQAILDSMDWLGMQPDEGPFYQMQRMDRYREVIAQMLQAGTAYHCYSSPEEVEAMREAARARGLKPRYDGTWRPEPGKTLPPVPAGRKPVVRFKNPQDGATGWNDMVKGPISFDNTELDDLIIARPDGTPTYNFCVVVDDWDMGITHVLRGDDHVNNTPRQINILRALGATLPEYGHVPMILGPDGEKLSKRHGAVNVMEYDAQGYLPEAMVNYLARLGWSHGDDELFTREQLVQWFDTRHLSKSASQWDPKKLNWVNAHYIKQMDNAELAARVAPRIERRGGNPAAVDLAAAMGLLKDRAETLEQLAESALLFCKPYQPAPAELAEQHLTPAAREALADFAQRAQGADWTREAIAALIKAVLADRGLKMPQLAIPLRVAVVGQTQTPAVDAVLALVGKDAVLQRLAAL
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_YERPS
Sequence: MSSKEQKTPNEQVSEEMENTAEQQVEATQETGECVDPRVAELEVQLSDALQRERESLLRAKAEVENIRRRTELDVEKAHKFALERFSSELLPVIDNLERALDTADKTNTELTSMIEGVELTLKSLLDAVGKFGIEVVGETHVPFNPEVHQAMTMLESADHEPNHVMMVMQKGYTLNGRLLRPAMVAVSKAKS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_YERP3
Sequence: MTILNHTLGFPRVGLKRELKKAQESYWAGNSTQEELLNVGRELRARHWQQQQQAGVDLVPVGDFAWYDHVLTTSLLLGNVPERHQNADGSIDIDTLFRIGRGRAPTGKPAAAAEMTKWFNTNYHYMVPEFQQGQQFKLGWTQLLDEVDEALALGHKIKPVLLGPITYLWLGKVKGEQFDRLSLLNDILPVYQQVLAELAKRGIEWVQIDEPALVLELPQEWLDAYQPAYQALQGQVKLLLTTYFDSIGHNIDTIRALPVQGLHVDVVAGHDDLAVLHKNLPKEWLLSLGVINGRNVWRADLSSWFERLQPLVNSRPLWLGSSCSLLHSPIDLNEETRLDAEVKSWFAFALQKCAELALLTQALNAPNDAKLAELAAYSAPIRARRSSSRVHNAQVEQRLAAITSQDIERQLPYEARAETQRKRFNLPAWPTTTIGSFPQTTEIRGLRLDFKQGRLDGKNYRTGISEHIKQAIAEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVIIGDISRPEAITVEWAKYAQSLTEKPVKGMLTGPVTILCWSFPREDVSRETIAKQIALALRDEVEDLEKAGIGIIQIDEPALREGLPLRRADWQAYLQWAVDAFKLNAAVAQNDTQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEDFAYPNEIGPGVYDIHSPNVPSVEWIEALLRKAAQRIPAERLWVNPDCGLKTRGWPETRQALANMVLAAQRLREEQI
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: FMT_STRZP
Sequence: MTKLIFMGTPDFSATVLKGLLTDDRYEILAVVTQPDRAVGRKKVIQETPVKQAAKEAGLSIYQPEKLSGSPEMEELMKLGADGIVTAAFGQFLPSKLLDSMDFAVNVHASLLPRHRGGAPIHYALIQGDEEAGVTIMEMVKEMDAGDMISRRSIPITDEDNVGTLFEKLALVGRDLLLDTLPAYIAGDIKPEPQDTSQVTFSPNIKPEEEKLDWNKTNRQLFNQIRGMNPWPVAHTFLKGDRFKIYEALPVEGQGNPGEILSIGKKELIVATAEGALSLKQVQPAGKPKMDIASFLNGVGRTLTVGERFGD
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: PAR4_CAEBR
Sequence: MEGPSSSSVPTASDAPSKYLLPSDSDDGIATSSAANVGARNHVTNTEKMEKEKKPSPMVLNVDPDYDYDEEDGGSCEEDQRGPPAPISREIVDGAIARRSRDRQISPGVKMSIGNYDDMEDDDEEAETPEEQKQRFLASMKRIRNQPQEAFDPPEDTEAMREFINRQVNDAMMFNRDNHIDYSPVNKPKEAKIIEGYLWGGIIGTGSYGKVKEVIDIYTITRRAAKIMKYEKLRKIPNGWDNIRSEMSILRRLNHRNIVKLIEVFNLPEKGKVYMIFEYCIGSVQNLIDMEPAHRLSIGESHAIFLELCHGLNYLHSKRVSHKDIKPGNLLLSIDMTVKICDFGVAEQICLFQSDGRCTKVNGTPKFQPPECVYGNHEYFDGYKVDMWSAGVTLYNMVSGKYPFEQQVLLRLYESIGTNPVEMPTNVELSKDLQDIIKRLLDKDFNTRPNISDVMQHPWFQTGFPEDQGLGRIMERMRTGDRPFTMYPSLQAMYDGAGSEVILDEDGNELVLPPPDLVKRGLKFFLELKILENLPGTLSLSSFPGFQTLEKRPGDGPPPSSDSGVVAAPDSASGDPLRRPSSRSMPTSAPPRPPSGAVEVVEAVAAPEAVVEDPVVEEAPAQQQEAPDRRRRGKRSLFSCIFRSRTDSS
What is the function of this protein?
Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis.  Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization.  Phosphorylates and regulates aak-2 in response to oxidative stress.  May also play a role in motility, behavioral response, regulation of lifespan and dauer formation through this pathway (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase par-4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex.
Protein: DAE2_IXOSC
Sequence: MKLFLISAALVVLGLAAVADAIGCSDPSPFQGRWVIGVDKKECVALVKEKCGNLRDYTTGRWVRGQHVKSNCGSIPKFTAIATFLKPGNKYLGHAAIFESCASDGIWVYDQWNAKPVERRKIRYGNTGKPNYNGDNFYTIEL
What is the function of this protein?
Tick gut and saliva antibacterial peptide that directly antagonizes host skin commensals which enter the ticks during feeding (PubMed:33306955).  Acts as a cell wall hydrolase that cleaves the bond between gamma-D-glutamate-meso-diaminopimelate of a peptide stem and D-alanine of another peptide stem in peptidoglycans (PubMed:25470067).  In vitro, degrades peptidoglycans from both Gram-negative and Gram-positive bacteria (PubMed:33306955).  Is not able to traverse the protective outer membane of Gram-negative bacteria (PubMed:25470067).  Is not able to kill Borrelia burgdorferi, one of the Lyme disease-causing bacteria (PubMed:33306955).
What are the official names of this protein?
Domesticated amidase effector 2, Dae2, Peptidoglycan endopeptidase Dae2.
Protein: E75_GALME
Sequence: MTLVMSPDSSYGRYDAPAPADNRIMSPVHKEREPELHIEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQSSTTRAHEQAAAAELDDGPRLLARVVRAHLDTCEFTRDRVAAMRNGARDCPTYSQPTLACPLNPAPELQSEKEFSQRFAHVIRGVIDFAGLIPGFQLLTQDDKFTLLKSGLFDALFVRLICMFDAPLNSIICLNGQLMKRDSIQSGANARFLVDSTFKFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNVELVERMHSRLKSCLQTVIAQNRSDGPGFLRELMDTLPDLRTLSTLHTEKLVVFRTEHKELLRQQMWVEDEGALWADSGADDSARSPIGSVSSSESSETTGDCGTPLLAATLAGRRRLDSRGSVDEEALGVAHLAHNGLTVTPVRPPPRYRKLDSPTDSGIESGNEKHERIVGPESGCSSPRSSLEEHSDDRRPIAPADDMPVLKRVLQAPPLYDASSLMDEAYKPHKKFRAMRRDTWSEAEARPGRPTPSPQPPHHPHPASPAHPAHSPRPIRAPLSSTHSVLAKSLMEGPRMTPEQLKRTDIIQQYMRRGETGAPTEGCPLRAGGLLTCFRGASPAPQPVIALQVDVAETDAPQPLNLSKKSPSPSPPPPPPRSYMPPMLPA
What is the function of this protein?
Orphan receptor possibly involved in the regulation of genes in the ecdysteroid cascade.
What are the official names of this protein?
Ecdysone-inducible protein E75, Nuclear receptor subfamily 1 group D member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMP_ACIB5
Sequence: MKLSNKSQALYDMIAPAVEACGVDLWGIEFLPQGKRSLLRIYIDRPVDENAEPVINEDGEVEQGRGIGVEDCVRVTQQVGAMLDVHDPISGEYALEVSSPGWDRPFFQLEQLQGYIGQQVALRLIAAVENRRKFQAKLLAVDLENEEIQVEVEGKHVLDIDSNNIDKANLIYQD
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_THEAB
Sequence: MTIQKILKMKNKEKIVMVTAYDAPTAKILEKAGVDIILVGDSLGNNVLGYDSTIPVTLEEMIIHLQAVRRGAPNSFIVADLPFLSYGYSIEESVKNAGLLIKNGANAVKIEGGAQNCEIIQKCLNIGIPVMGHIGFTPQSLNMFGGYKVQGKEESAKKKLLDNALALENCGVFSIVLEMVTESIAKEITEKLSIPTIGIGAGRYCDGQVLVFHDIVGLNPEFKPKFSKMYANTFEIMLNAIEKFKMEVKDKTFPSKENVFEEGGK
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_ANAMM
Sequence: MSGVRIPLFPRFIPHGTVKLESAALKKLNSLELSGGYAVAVSGGVDSITLLNLVAALHKTQATSRPVVLTGNHGFRAEADHETRFVQKRAVALGLDCEILRWNRHRTSSKSQETAREIRYSLLHQWCTEHSVKFLLTAHNKSDQAETVLMHLERGSGIDGLSGMHERSVFGDITIYRPLLGFTRQEILEYATQKQLSWVEDPSNQDPKYRRTFFRNLIAESKNPGVVVDRLCRTTSHMHRALACILHYVRSSLDYCLEFSPLGFITVKSQELRSVPEEIASRLLLLSLMAMGGKDHKPRYSAFWPILTKILQGQDFTPRTLHGCKVRKEPDGNFSIVRELARIETKIGVKTIAETIQWDRRFAIKIMCTHNASAAETTSCSAKHAPNPSEETQNLYITPLGNGSLPEHLVHVNRDVACSLPVLAHGDKVLAYPWQNHNIGVSPTISVEEVLVRRGVINLICHQLYR
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLSA_PSEP1
Sequence: MQTLLNEILEEVRPLIGKGKVADYIPALADVPANQLGIAVYGNDGSYHCAGDARVPFSVQSISKVFSLVQAIGHSGEAIWERLGHEPSGQPFNSLVQLEFERGRPRNPFINAGALVICDINQSRFAAPTLSMRDFVRRLSGNPHISINTRVADSEYQFRARNAAMAYLMQSFGNFHNEVETVLRSYFSYCALQMNCLDLARAFCFLANDGFCKHSGEQILTRRQTQQVNSIMATSGLYDEAGNFAFRVGLPGKSGVGGGIVAIVPGQFTVCVWSPELNAAGNSLAGMAALELLSSRIGWSVF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: ST1E1_MOUSE
Sequence: METSMPEYYEVFGEFRGVLMDKRFTKYWEDVEMFLARPDDLVIATYPKSGTTWISEVVYMIYKEGDVEKCKEDAIFNRIPYLECRNEDLINGIKQLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLMITSYPNPKSFSEFVEKFMQGQVPYGSWYDHVKAWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERKPSAELVDRIIQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGIIGDWKNHFPEALRERFDEHYKQQMKDCTVKFRMEL
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (By similarity) (PubMed:9765259).  Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation.  Also sulfates dehydroepiandrosterone, pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency.  Does not sulfonate cortisol, testosterone and dopamine (By similarity).  May play a role in gut microbiota-host metabolic interaction.  O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria.  The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
What are the official names of this protein?
Sulfotransferase 1E1, ST1E1, Estrogen sulfotransferase, testis isoform, Sulfotransferase, estrogen-preferring.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RS5_BURP0
Sequence: MAKMQAKVQADERDDGLREKMISVNRVTKVVKGGRILGFAALTVVGDGDGRVGMGKGKAKEVPVAVQKAMEQARRNMFKVPLKNGTLQHEVHGKHGASTVLLAPAKDGTGVIAGGPMRAVFDVMGVQNVVAKSHGSTNPYNLVRATLDGLRKQSTPADIAAKRGKSVEEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: CH10_BORGP
Sequence: MKNIKPLADRVLIKIKEAESKTISGLYIPENAKEKTNIGTVIAIGSNKEEITVKVGDTVLYEKYAGAAVKIENKEHLILKAKEIVAIIEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I68A3
Sequence: MSLLTEVETPTRNGWECKCSDSSDPLVVAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: PDXT_BACP2
Sequence: MLTIGVLGLQGAVREHIQSIEACGAEGKIIKRAEELVSVDGLIIPGGESTTMRRLMDTYQFIEPIKAFAAKGKPIFGTCAGLIMLAKHIEDRDNAHLGLLNVSVARNSFGRQVDSFEADLEVKGLDAPFTGVFIRAPHIISADESVEVMAEYDGRIVMAKENNILGCSFHPELTDDHRLTQLFVEMVKTYKTKLAV
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: RN166_CHICK
Sequence: MFRSLLVAAAQRPQAPGPGPPRPPPPAGPAAEALEAQFSCPICLEVFHRAVGIAGCGHTFCGECLQPCLQVPSPLCPLCRMPFDPKKVEKASSVEKQLSSYKAPCRGCSKKVTLAKMRSHVSSCAKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFVCPYCGARNLDQQELVKHCMENHRNDPNKVVCPVCSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYNIDEEAALQAALALSLSEN
What is the function of this protein?
E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF166, RING finger protein 166, RING-type E3 ubiquitin transferase RNF166.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPT11_BOVIN
Sequence: MAEEEDYMSDSFINVQEDIRPGLPMLRQIREARRKEEKRQEANLKNRQKSIKEEEQERRDMGLKNALGCENKGFALLQKMGYKSGQALGKSGDGIVEPIPLNVKTGKSGIGHETLLKRKAEEKLESYRRKIHMKSQAEERAAEQFRIRLKNKQDEMKLEGDLRRSQRACQQLDTQKNIQVPREAWYWLRPEEETEEETEEEKEQDEDEYKSEDLSVLEKLQILTSYLREEHLYCIWCGTAYEDKEDLSSNCPGPTSADHD
What are the official names of this protein?
G patch domain-containing protein 11, Coiled-coil domain-containing protein 75.
What is the protein family that this protein belongs to?
Belongs to the GPATCH11 family.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore.
Protein: PETD_GOSHI
Sequence: MGVTKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMVSVPAGLLTVPFLENVNKFQNPFRRPVATTVFLIGTAVALWLGIGATLPIDKSLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CUTI3_FUSVN
Sequence: MKFFALTTLLAATDSALPTSHPVQELEARQLGGGTTRNDLTNGNSASCADVIFIYARGSTETGNLGTLGPSIASKLESAFGRDGVWIQGVGGAYRATLGDNSLPRGTSSAAIREMLGLFQQPNTKCPDATLIAGGYSQGAALAAASVEDLDSAIRDKIAGTVLFGYTKNLQNHGRIPNFPADRTKVFCNTGDLVCTGSLIIAAPHLTYGPDARGPAPEFLIEKVRAVRGSA
What is the function of this protein?
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (By similarity).  Degrades cutin, a macromolecule that forms the structure of the plant cuticle (By similarity).  Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of fungal infection (By similarity).
What are the official names of this protein?
Cutinase 3, Cutin hydrolase 3.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Secreted.