PharMolix/UniProtQA huggingface dataset:
Protein: HEMH_PSE14
Sequence: MTDHALLLVNLGSPASTQVADVRSYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSKRLQQAMKKEWSHGPVELAMRYGEPSIETVLTRLSEQGFKKVTLAPLYPQFADSTVTTVIEEAKRVVRAKSLKMQFSVLQPFYDQPEYLSALVESVRPHLEQPYDHLLLSFHGLPERHLHKLDPTGKHCLKDDCCMTAPAEVLATCYRAQCIQSAATFAKRMGIPDGKWSVSFQSRLGRAKWIEPYTEARLDELAAQGVKRLLVMCPAFVADCIETLEEIGDRGAEQFKEAGGEELVLVPCLNDDPNWAKELNRLCERAPLML
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T904_LACLA
Sequence: MHRRPSKQQVEREILSEKIKAVFHEHKGRYGAVRITKVLHNTGIMTNTKRVGKLMHLMGLYAKGSRYKYKHYNRKGASLSRPNLINQIFKATAPNKVWLGDMTYIPTKEGTLYLAVNIDVFSRKIVGWSMSSRMQDKLVRDCFLQACGKEHPQPGLIVHTDQGSQYTSSRYQSTLRQVGAQSSMSRKGNPYDNAMMESFYKTLKRELINDAHFETRAEATQEIFKYIETYYNTKRMHSGLDYKSPKDFEKYNS
What is the function of this protein?
Involved in the transposition of the insertion sequence.
What are the official names of this protein?
Transposase for insertion sequence element IS904.
What is the protein family that this protein belongs to?
Belongs to the transposase IS3/IS150/IS904 family.
Protein: UPK3B_BOVIN
Sequence: MGLPSRQPRLWLLLLVVLGWPQPCLTLDLIPYTPRITSWDLEGKVTATTFSLEQPRCVLDRHSSAADTVWLVVAFSNASRVFQNPQTLAEIPASPRLLTDGHYMTLPLTMDQLPCEDPADGSGRAPVLRVGNDAGCLADLHQPRYCNAPLPGPGPYRVKFLLTNSRGSPQAETRWSDLIALRQGKSPGSIDTWPGRRSGDMIIITSILSSLAGLLLLAFLAASSVRFSSLWWPEEAPEQLRIGSFMGKRYMTHHIPPSEAATLPVGCEPGLERFPSLSP
What is the function of this protein?
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells.  May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells.  It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
What are the official names of this protein?
Uroplakin-3b, UP3b, Uroplakin IIIb, UPIIIb, p35.
What is the protein family that this protein belongs to?
Belongs to the uroplakin-3 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
Protein: Y2522_CUPPJ
Sequence: MAGHSKWANIKHKKAAADAKRGKIWTRLIKEITVAAKLGGGDPDSNPRLRLSMDKAMDANMPKDNIQRAIQRGVGGLEGVNYEEIRYEGYGLSGAAIIVDCLTDNRTRTVAEVRHAFSKHGGNMGTEGSVAFMFTHCGQFLFAPGTPEDKLMDAALEAGADDVVTNEDGSIEVTCPPNDFSAVKAALEAAGFKAEVADVVMKPQNEVDFTGDDAVKMQKLLDALENLDDVQEVFTNAVIEE
What are the official names of this protein?
Probable transcriptional regulatory protein Reut_A2522.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK22_RHDSA
Sequence: MSTSVKQTEARAIAKYIRMSPFKVRRVLKQIRGRSYKEALMILEFMPYAACKPVLQLLQSAAANAQNNYGLQKDQMIVNYAYADPGPVLKRFRPRAQGRGFKIKKPTCHITVSLKEVL
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COX2_APOMY
Sequence: MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKNFENWSTSMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: INTG_SPV1C
Sequence: MKYIINNFNLFDLQAKLKNFLSKNYKNKYYKRIKQKIFSYINLCNDYYNGNFLLKDLIKKYFKNKFSTFYYWANKILIAYKSNDFAELLLKSTIPNNINYQYSNDVRQNICDLYFKYCNKHAGGVLSLFYNLKKGIHGEELKNKAPKNLKTFFRWLKKDERWLKIKNKIKEIKKQHSRYEVKEIGLLQMDAKYFVPSKFSVDKKYYVYDFIDEKTRLALGYVYDKLSTDNAIDAVKKAISDFKNIFGIIITRIRTDNGSEFINNYRNNQKISVKKTNFTQFLTDKNILHQTTPVRSPQSNGKIERFHQNYTKLFVFEEKILNAVSLQNKLNDYYYFYNFERVHKSLNFQTPFNFLNSLSLIK
What is the function of this protein?
This protein may encode an integrase, which is necessary for integration of the viral DNA into host genome.
What are the official names of this protein?
Putative integrase ORF3.
What is the protein family that this protein belongs to?
Belongs to the plectrovirus integrase ORF3 family.
Protein: ARGC_PELTS
Sequence: MAVKVSIIGATGYTGAELVRILSRHPQAELVALTTQSYAGKKFWEVYPHLYGYNQLTCEEMNLPEIMESSDIVFVALPHGHAMPAAREAARRGRKLIDLGADFRLKDFRTYEQWYRVEHTARELLAGAVYGLPEVNRREIREAWLVANPGCYPTSAILALAPLLKNRLIDTSSIIIDSKSGVSGAGRGLALGSHFSEVNENFKAYNVAVHRHTPEIEQELGRIAGEDVAVTFTPHLLPVTRGILSTVYAKLAAPAGEEEIREVYLDYYRGEPFVRVLPAGMLPQIKWVAGTNHCDIGLTVDRRTGRVVVLSAIDNLVKGASGQAVQNMNIICGLPEDTGLAGPGLYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SBMC_KLEP3
Sequence: MNYSITTLGKKTIAGFHLVGPWDQTVKQGVEQLMMWVENHQVPAREWLAVYYDNPEEVPAEKLRCATVVAVDEDYVIPANSEGVILAAVAGGDYACARARVVDYDFATPWMQFFDSLLQSTTYRVAPRPCFEIYLNDGNHDGYWDIDMYVPVERVAS
What is the function of this protein?
Inhibits the supercoiling activity of DNA gyrase.  Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase.  It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
What are the official names of this protein?
DNA gyrase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDFS_EUBBA
Sequence: MKDFEFFAPKTLEEAKGLLHQYKDVPPAIIAGGTDLVIEINDRWEKPDVVIDIKKLKELEYIRVEENTIHIGALSTFTQIENHPFIRSHVRALYKAASQVGSPQIRNLGTIGGNLSTSSVAGDGVSAMTTLDATVVLESVRGTRQMKLTDFFDGEGFKRRNALEADEIMTEVIIDRPDAHSASAFYKLAKRKSLAISVIGGGMAVKVDDAGVCTWASMRGGCIGRYPLHFKQAEEMLVGAPLTMETMEATLPILHDTVYDMARARPSVLYKKESVQGVFKKLFVDILDQLEGGCNE
What is the function of this protein?
Catalyzes the hydroxylation of nicotinate to 6-hydroxynicotinate.  Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs.
What are the official names of this protein?
Nicotinate dehydrogenase FAD-subunit, NDH, Nicotinic acid hydroxylase FAD-subunit, NAH.
Protein: PIRL3_ORYSJ
Sequence: MPGLRHPSVLRAMTRAVADVSAARSALQVLGPRPDHELVDSSRAIVAATDAEAGGSRRVPEGDLEACRAVVRLEETHDAYEALLQEAEGRLEAVYRSAMEGKDLEEPDGRDESAAAAAGDDAAVQEEVIAVLRQAEEGKPVESVRLVDRQLRHLPEAFGRIQGLRVLDVSRNQLEVIPDAIGGLDHLEELRLASNALISLPDSIGLLLNLRILNVGSNRLRSLPDSISKCRSLIELDASYNGLAYLPTNIGYELVNLRKLWVHMNKLRSLPSSICEMRSLYLLDAHFNELCGLPSAIGKLSSLEILNLSSNFSDLKDLPASFGDLLNLRELDLSNNQIHALPDNFGRLDKLEKLNLEQNPLSMPPMEIVNKGVDAVKEYMLQRWLDILLEEERKSIAAAESPQAPTTPSAWLARSVSWVSDVSGSLVGYLSGENKTEKDAYLDQQY
What is the function of this protein?
Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
What are the official names of this protein?
Plant intracellular Ras-group-related LRR protein 3, Intracellular Ras-group-related LRR protein 3, OsIRL3.
What is the protein family that this protein belongs to?
Belongs to the SHOC2 family.
Protein: PEPT_SHESH
Sequence: MRQALLERFLRYIKIDTQSDGKNLESPSTPSQFEFAKLLKLELEELGFHRVELSDKGYLSASVPKTIEGVPCIGFIAHLDTAPDFSGANVTPQLINDYDGSEIKLGEDEVLSPELFPHMLKYLGKTLITTDGTSLLGGDDKAGISEIITALHYLLEHPEIPHGEIRLCFTPDEEIGRGADHFDVPEFGAQWAYTIDGGQLGELEFENFNAATAVITAKGNNCHPGTAYGVMVNAQTMAARFHAKMPLHDTPEGSKDYDGFFHLINMQGQTEEAELTYIIRDFDLELFEKRKTWLTERVKSYNADLVLGSLEIEITDSYFNMKEQILPYPHIIDIAEKAITNQGVTPLIKPIRGGTDGSRLSYMGLPCPNIFTGGHNFHGKHEYICLESMEKAVDVIIDICKLTAEEQQA
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFI_SALAR
Sequence: MDLASLRAQQIELASSVCREDRLDKDPPAFIGGADVGFEQGGEVTRAAMVLLKYPSLELVEYKVARIATTMPYIPGFLSFREYPALLAAWEQLSQKPDLLFVDGHGISHPRRLGVASHFGLLVDVPTIGVAKKRLCGKFEPLSAEPGALSALMDKGEQLAWVWRSKARCNPLFIATGHRVSTDSALAWVQRCMKGYRLPEPTRWADAVASGRPAFVRWQEIQR
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT5E_CONTE
Sequence: NIQIICCKHTPKCCT
What are the official names of this protein?
Conotoxin tx5e, Tx5.5.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TTC36_RAT
Sequence: MGTPNDQAVLQAILNPNTPFGDVVGLDLEETEEGDEDGVFPQAQLEQSKALELQGVRAAEAGDLHTALERFGKAISLLPERASAYNNRAQARRLQGDVAGALEDLERAVTLSGGRGRAARQSFVQRGLLARFQGRDDDARRDFEQAARLGSSFARRQLVLLNPYAALCNRMLADMMGQLSAPSNGR
What are the official names of this protein?
Tetratricopeptide repeat protein 36, TPR repeat protein 36.
What is the protein family that this protein belongs to?
Belongs to the TTC36 family.
Protein: RPO10_PYRAE
Sequence: MIIPIRCFTCGKPLGHLYAVFKRRVLAGEHPGRVLDDLGVTRYCCRRTLMAHVEWIDDVLLYERRS
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit N.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1544_HAEIN
Sequence: MNHLIIFAHPNSVRSFGRAIANRIEQISQENGVNVFFRDLYEMNFNPILSHEELQNANNGIIPEDIQQEHDFILQADLITLVYPLWWMGFPAILKGYLDRVLSHGFAYKTENGESVGLLKNKQMQQFITIGSNVDKYKEFGVDKSLNHCLINGLFNYCGIENVEFELFGDIHLIDDKARKAMIELAAQKTQAKLTALLKEKE
What are the official names of this protein?
Uncharacterized NAD(P)H oxidoreductase HI_1544.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family.
Protein: GBB1_DROME
Sequence: MNELDSLRQEAESLKNAIRDARKAACDTSLLQAATSLEPIGRIQMRTRRTLRGHLAKIYAMHWGNDSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNMCSIYNLKTREGNVRVSRELPGHGGYLSCCRFLDDNQIVTSSGDMSCGLWDIETGLQVTSFLGHTGDVMALSLAPQCKTFVSGACDASAKLWDIREGVCKQTFPGHESDINAVTFFPNGQAFATGSDDATCRLFDIRADQELAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTMKAERSGILAGHDNRVSCLGVTENGMAVATGSWDSFLRVWN
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family.
Protein: RL34_BLOFL
Sequence: MKRTYQPSVLKRNRTHGFRLRMSTQNGRQILSRRRAKGRIRLIVSS
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: YSNA_STRPR
Sequence: MMQQVKRAFKYRFYPTDEQAAELSRTFGCVRLVYNKALEGRTRAWYGEQRRVSYVQSSAALTEWKKTEELAFLSEVSSVPLQQALRHLQTAFANFFAKRSKYPRYKSRKKSRASAEYTRSAFTWRNGQLTLAKTAEPLDIRWSRPLPEGAEPTTVTVSRDRAGRWFVSLLCEDTITPAPATTAAVGIDAGITSLVTLSTGEKITNPKHERRDRARLAKAQRDVSRKAKGSANRKKARRKVARVHARITDRRCDFLHKLSTRLVRENQTVVIEDLTVRNLLKNGKLARAISDAAWTELRSMLEYKCAWYGRELVVIDRWFPSSKLCGTCGTVRGKLPLNVREWTCDCGAVHDRDVNAARNILAAGLAASACGDGIRPQRESSRTGRSSVKQEPQRATAGIPRL
What is the function of this protein?
An RNA-guided dsDNA endonuclease.  When guided by an RNA derived from the right-end element of its insertion sequence element (IS), cleaves DNA downstream of the transposon-associated motif (TAM).  Cleaves supercoiled and linear DNA in a staggered manner 15-21 bases from the TAM yielding 5'-overhangs.  Binds reRNA, an approximately 150 nucleotide base sRNA derived from the 3' end of its own gene, the right end (RE) of the insertion sequence (IS) plus sequence downstream of the IS.
What are the official names of this protein?
Putative RNA-guided DNA endonuclease, ORF401.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transposase 35 family.
Protein: VE6_HPV6A
Sequence: MESANASTSATTIDQLCKTFNLSMHTLQINCVFCKNALTTAEIYSYAYKQLKVLFRGGYPYAACACCLEFHGKINQYRHFDYAGYATTVEEETKQDILDVLIRCYLCHKPLCEVEKVKHILTKARFIKLNCTWKGRCLHCWTTCMEDMLP
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: SPC25_DROEU
Sequence: MAITTAESSYEKRIKALFDKQVQMEAREASVIKKVFKFNSNLLDVKEAVVHHHRDVEKLQKVVIQRREEMEKRVSFMEELAQEVEATKQRNLVMREQIKQQKMLVRQRKNEIMESIHTLSKATGTYINREALPARVKGVTVLHGDNRDELIPFDLKATDVEGLDSLCQHLHSLNIDVSQWQQLVSLATEMSMKSHPATPPKDAAKCKSIIEIDLTSPTIQA
What is the function of this protein?
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis.  Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.  Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics.  The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
What are the official names of this protein?
Kinetochore protein Spc25.
What is the protein family that this protein belongs to?
Belongs to the SPC25 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore.
Protein: UGT60_CAEEL
Sequence: MYLPIFCIFLSVVDSLRILQIVPGFTNSHVLFNYRLAETLRFLGHDVKMWTQMEMAMLDTGNNKLPEGVSEYRIPIHFTDTLKTEGLKVFQSMMFESGDAHDLWWTGQEFKDMRVEACEQMLRHDESVYEDFRKDGFDVAIAHFHDLCPLAIAKKMNVKRVIWITHGTSIYEFSAVQLGLRTIPSTIPHPLSSAGFSQLFLDRVQNTLWHLSLLDFVNLPQNLLVDENLFYREFVGADQDDLWDLAKTTVPSLLINGDRMLDFPRPLPIHIAFSGELGVSKGKKLVMEKWLEDIIEKPSDGLIVFSLGTVSNTTNMPAQMINSFLGAFGKLKTYTILWRMEKSVAGAEKYENLHLVKWLPQKDIMRHPKMKLMIAHGGYNSFLEAAQAGIPAVLMPLFADQKINAKRAQRYGMATVLDKLDLTINNVYGAIKEALKPEYSTNAKKLSAMLSDQVARKPYSALRYSLKLATSPKPSLFTLKSQHLSFLEFHNLDIFSIVLLTAFIVCF
What are the official names of this protein?
Putative UDP-glucuronosyltransferase ugt-60, UDPGT 60.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RLMF_PECAS
Sequence: MTKPAVQKSGLHPRNRHRDRYDFPALKQSYPALIPFVKVNAYGDESVDFANPEAVKTLNQALLQHFYQIEHWTIPDGFLCPPIPGRADYVHHLADLLAEDNRSVVPRDASVLDVGCGANCVYPLIGHREYGWRFTGSEVNPLAMKAANETIEANSGLNRSIRLRRQKNSKAILAGIIHKNDSFDAVMCNPPFHASAEDAREGSQRKLHNLGLDKRSPLNFGGQQDELWCEGGELAFIGQMIKDSVSFGRQCLWFTSLVSRKEHLPEIYRALEAVDAEKVRTIDMAQGQKQSRFVAWSFLDTAARARWLQKR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_METM5
Sequence: MNILRRGRLGSNVKEDVMKFTTSLEFDKEIFESDILCDIAHTTMLVEQNVISEENGKKIIAELKKIAEKGMETLDLDPSLDDIHMVIESELIKELGEDVAGRMHTGRSRNDEVATDLRLSLRKKVLEIITHLITMEKNMLAVSNEHKETLTVGYTHLQQAQPVTFGHQILSHISAIERDISRFFDTYNRINLSPLGCGAMATTGFNLNRKRTQELLGFYGLIENSMDGVSSRDFIVETMANISMLGTNLSKICEELVVFSSAEFNTIEIANEYTSTSSIMPQKKNPDVAEITRAKLSTLNGELVTVLTIMKALPNTYNRDLQEISPHLWKSVYTLIDSIQMVDGMISTVKVNKERMKENAEKNYSTATELADTLVRECGIAFRMAHGIVGELVKRSIEEKVEIKEIISEVLEKNNLSLSQEKIDTALDPFENVKLRNVIGGPAPEEVERAISSFNEKISAYKENLDEKIAEIESVKENLLK
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_STAAR
Sequence: MKQSKVFIPTMRDVPSEAEAQSHRLLLKAGLIKQSTSGIYSYLPLATRVLNNITAIVRQEMERIDSVEILMPALQQAELWEESGRWGAYGPELMRLQDRHGRQFALGPTHEELVTSIVRNELKSYKQLPMTLFQIQSKFRDEKRPRFGLLRGREFIMKDAYSFHADEASLDQTYQDMYQAYSRIFERVGINARPVVADSGAIGGSHTHEFMALSAIGEDTIVYSKESDYAANIEKAEVVYEPNHKHTTVQPIEKIETPNVKTAQELADFLGRPVDEIVKTMIFKVDGEYIMVLVRGHHEINDIKLKSYFGTDNIELATQDEIVNLVGANPGSLGPVIDKEIKIYADNFVQDLNNLVVGANEDGYHLINVNVGRDFNVDEYGDFRFILEGEKLSDGSGVAHFAEGIEVGQVFKLGTKYSESMNATFLDNQGKAQPLIMGCYGIGISRTLSAIVEQNHDDNGIVWPKSVTPFDLHLISINPKKDDQRELADALYAEFNTKFDVLYDDRQERAGVKFNDADLIGLPLRIVVGKRASEGIVEVKERLTGDSEEVHIDDLMTVITNKYDNLK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GALD1_XENLA
Sequence: MKKQGAPVSGGGTERLTKPSCLMVGSAVAEGVSAQSFLHSFTLASSAFNLQVATPGGKALDFVGISETDSRWFQDFQLKPYSNPARLESIDGSRYHALLIPHCPGALTDLANSGYLARILQHFTAEKKPICAIGHGVTALCCATNQDKSWVFQNYSLTGPSVYELVRRPEYASLPLILEDYAKDSGATFSASEPDAIHVVLDRHLITGQNDNSTMPAVQNLILLCNGRK
What are the official names of this protein?
Glutamine amidotransferase-like class 1 domain-containing protein 1, Parkinson disease 7 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HCST_HUMAN
Sequence: MIHLGHILFLLLLPVAAAQTTPGERSSLPAFYPGTSGSCSGCGSLSLPLLAGLVAADAVASLLIVGAVFLCARPRRSPAQEDGKVYINMPGRG
What is the function of this protein?
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation.  Functions as docking site for PI3-kinase PIK3R1 and GRB2.  Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways.  Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells.  In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors.  In T-cells, it provides primarily costimulation for TCR-induced signals.  KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.
What are the official names of this protein?
Hematopoietic cell signal transducer, DNAX-activation protein 10, Membrane protein DAP10, Transmembrane adapter protein KAP10.
What is the protein family that this protein belongs to?
Belongs to the DAP10 family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: MGSA_YERPY
Sequence: MELTTRTIAARKHIALVSHDHCKKSLLAWVMENRDLLAQHELYATGTTGNLVQKATGIDVHCLLSGPMGGDQEVGALISEKKIDILIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNRSTADFLIGSTLFSSEVTIAIPDYDRYMQQRLDLK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: PLAS_LACSA
Sequence: AEVLLGSSDGGLVFEPSTFSVASGEKIVFKNNAGFPHNVVFDEDEIPAGVDASKISMSEEDLLNAPGETYAVTLTEKGTYSFYCAPHQGAGMVGKVTVN
What is the function of this protein?
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.
What are the official names of this protein?
Plastocyanin.
What is the protein family that this protein belongs to?
Belongs to the plastocyanin family.