PharMolix/UniProtQA huggingface dataset:
Protein: GLGC_DESRM
Sequence: MQRKECVAMLLAGGQGSRLGVLTKKLAKPAVPFGGRYRIIDFTLSNCNNSGFDTVGVLTQYQPLALNTYIGIGSHWDLDRKNGGVTVLPPFVKEMGGEWYKGTANAIYQNIEFVDQYKPKYILILSGDHIYKMDYSLMLDFHKEKQADATIAVIEVPWQEASGFGIMNTAKDARIVEFEEKPKVPRSNLASMGVYIFNWELLKAYLEEDERNPRSSNDFGKNIIPLMLEAGQRMFAYPFKGYWRDVGTIESLWQANMDLLLENPKLDLNDQKWRIYSVTPHQPPQYVAPSARVNCSLINEGCMVFGNVYHSILFPGVDIGKGSTIRESVILSNVKIGKNVIVERAIVGVETIIEDNCHIGCKENSCPEDCSRITVVEGNIIVPTGSFIKKDCQLVGKAG
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: MTNC_PSE14
Sequence: MPIKAILTDIEGTTSAVSFVFDVLFPFAKKHLPGFVRQNAGQPAVASQLQAVRTEAGEPDADVERVIAILLEWIAEDRKATPLKALQGMVWEQGYNAGQLKGHVYPDAVDALKHWHQQGYRLYVYSSGSIQAQQLIFGCSEAGDLSGLFSGYFDTTSGPKREAQSYRTIAQAIECPAENILFLSDIVEELDAAQAAGMITCGLARDGGVLVGHRYVSSFALIDPASF
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: CYC_GORGO
Sequence: MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIWGEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE
What is the function of this protein?
Plays a role in apoptosis.  Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol.  Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: STML2_RAT
Sequence: MLARAARGTGALLLRGSVQASGRIPRRASSGLPRNTVILFVPQQEAWVVERMGRFHRILEPGLNVLIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNANIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAGALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTVLLPSNPSDVTSMVAQAMGVYGALTKAPVPGAQNSSEARRDVQTTDTSIEELGRVKLS
What is the function of this protein?
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria.  Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes.  Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress.  May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria.  Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria.  May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity).
What are the official names of this protein?
Stomatin-like protein 2, mitochondrial, SLP-2.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Mitochondrion. Mitochondrion inner membrane; Lipid-anchor. Mitochondrion intermembrane space. Membrane raft. Cytoplasm, cytoskeleton. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells.
Protein: SPLF_STAA1
Sequence: MNKNIIIKSIAALTILTSVTGVGTTMVEGIQQTAKAENTVKQITNTNVAPYSGVTWMGAGTGFVVGNHTIITNKHVTYHMKVGDEIKAHPNGFYNNGGGLYKVTKIVDYPGKEDIAVVQVEEKSTQPKGRKFKDFTSKFNIASEAKENEPISVIGYPNPNGNKLQMYESTGKVLSVNGNIVSSDAIIQPGSSGSPILNSKHEAIGVIYAGNKPSGESTRGFAVYFSPEIKKFIADNLDK
What are the official names of this protein?
Serine protease SplF.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1B family.
What are the subcellular locations of this protein?
Secreted.
Protein: FTSP_AGGAN
Sequence: MKNCSRRQLLKTTLFSTALFSVPAPLLAATRPTLTIPPLFETRRGKPIFLNLQNTQASLLPGKRTEVWGFNGVYLGPTIKIKKDDFAKLNWKNNLPQFVAMNIQGLQASGELIGGIAKNLQKDETWAPIIPITQAPSTCWYHACTLANSAYQTYRGLLGLWMIEDKESTKLGLPQKYGVDDIPLILQDMQLNTEGTQLFQQHQGRFIGERLFVNGQEAPYLTVPRGLVRLRVLNASLSRTYELRFDDEREFTLIAQDLGFLPQGQKRNVVMLAPSERVEILVDLNDGENVSLITGTKRGILDNISHFFGSDGELIDNTILELRPEGLAGAFEKKEQTWQFNTDAPSLLSTKVQQERAFHIDVGNATINKNRLDPRRLDVSAKLGSVERWTLSASSPVGFAIRGAKFIVESVNGKALEASEIGWKDSVLINGKVSILVKFENTSSNNYPFTFGASDLMLADKGCIGLMLVQ
What is the function of this protein?
Cell division protein that is required for growth during stress conditions.  May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.
What are the official names of this protein?
Cell division protein FtsP.
What is the protein family that this protein belongs to?
Belongs to the FtsP family.
What are the subcellular locations of this protein?
Periplasm. Note=Localizes to the division septum.
Protein: YCAD_ECO27
Sequence: MSTYTRPVMLLLSGLLLLTLAIAVLNTLVPLWLAQEHMSTWQVGVVSSSYFTGNLVGTLLTGYVIKRIGFNRSYYLASFIFAAGCAGLGLMIGFWSWLAWRFVAGVGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYVGTFLGQLLVSKVSTELMSVLPWVTGLTLAGILPLLFTRVLNQQAENHDSTSITSMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLNHKGVSNASIGFWMAVLVSAGILGQWPIGRLADKFGRLLVLRVQVFVVILGSIAMLSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFTAMLMQNFSDNLLFIMIASVSFIYLLMLLRNAGHTPKPVAHV
What are the official names of this protein?
Uncharacterized MFS-type transporter YcaD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MCA1B_ASPNC
Sequence: MYYHHSHQGWSGDYPRQQSWGQPPPSSYPYPYSSNAQYQPPPGPPPTSHYAPPPGPPPSHYYPPPGSYPSPAPSPYYGQHHTPTPPPQSSSPHQRSYHNHSPSWGQNLPPRPPQESQHFGRGAPSNYRFQYSNCTGRRKALLIGINYIGQPNQLRGCINDVTNMSTFLNEKYGYRREDMVILTDDQKNPMSIPNKANILRAMQWLVKDAQPNDSLFIHFSGHGGRTPDLDGDEEDGYDDVIYPLDYRTAGHIVDDDMHAIMVRPLRPGVRLTAIFDSCHSGTALDLPYVYSTQGILKEPNLAKEAAMDLFSAINSYGKGDLSSVAQTAIGFFKKAANGDTARQRTVMTKTSPADVVMFSGSKDTQTSADTFQDGEARGALSWAFIKTLQQRPNQSYLQLLNSIRNELEGKYTQKPQLSCSHPLGMCNASLVPPRTEID
What is the function of this protein?
Involved in cell death (apoptosis).
What are the official names of this protein?
Metacaspase-1B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
Protein: PU91_BRACO
Sequence: MKQFIVLTVVLLAIQELQGGAVLTVDEKCTCKDTLNTLSKDDLILRLITCTQRNENLEGIITAIKKDNDFLNKENDALRAQNCELTAQLAKEKKAREAAENALCECQKNSELLKQTIEQLKKELAQTKQELANCKEALANCKAENAKLLKKIEELNCTITQLQEELEQCRARERDLQCQLDECNKKLTICNNELIACRKQQEELRCEIERLNAEIKRLEAQNAACENALNTLRCETSEFLAIATQRQSKLTTIIQSAEAESTAIGASYIGFRNTHDLTCAPCGGPA
What are the official names of this protein?
Puff II/9-1 protein.
Protein: UPE28_UPEMJ
Sequence: GILDVAKTLVGKLRNVLGI
What is the function of this protein?
Shows antibacterial activity against B. cereus, L. lactis, S. epidermidis and S. uberis.
What are the official names of this protein?
Uperin-2.8.
What are the subcellular locations of this protein?
Secreted.
Protein: FB133_ARATH
Sequence: MDLLSSLPDEVRCLILSFLTTKESASTSVLSKKWRNLFALVPNLDFDDSEFLHPEEGKRERDGILQSFMDFVDRVLSLQGNSSIRKFSLKCETGVPPARVNRWLCEVLQRDVSDIDLTIDLGYGYYLPEELFVSETLVNLKLKSAFNIDWWPGAEGTSLPMLKSLCVYGVRVFCDDELQELLPCFPVLEELQMSNMQWLDSDETVSSATLTTLHITGIRSENPKSISFDTPNLLSFVYTDFVAEDYPLVNMKNLSLARLALRANDDQIKRVRGPSNDLLEYDVVRHFGNVVKLMNGIQNVQELHLCPDTLELLSVCCESMPVFNNVKKLLIYSDEDRGWQAVPVLLRNCPRLETLIFEGIVHHVTDKCGDACDCIFRKDKGRSLKSCPVKVVEINGFGVTMKEKYLIEHFLDYFSCLKEMKIYINCEEDGVTQQVMKNREVSKLVLDEMEEYNEFYSCNVKLFLCKKKSIPQ
What are the official names of this protein?
F-box protein At3g03040.
Protein: METN1_ENTFA
Sequence: MIELKNISVTFQQKKQEIQAVQDVSLTIDKGDIYGIVGYSGAGKSTLVRVINLLQRPTAGTVIINKENILTFSKKELRQQRKKIGMIFQHFNLMKERTIFSNIDFSLKYSGLSKSERRQKISHLLELVGLSEKRDAYPSQLSGGQKQRVAIARALANDPEILLCDEATSALDPKTTGQILALLKKLNQELNLTIVLITHEMQVVKEICNKVAVMENGCVVESNDIVSIFSQPQQPLTKDFIRTATHIDQALTTILEHPKLADLDKNQELIEFSYVGDQTNEPLIAQLYSQYQVYTNILYGNVEIVQNVPIGHLIVVLSGDEAQRQQALTYLAKQGVRTNVLKTYQQTKQKQNLQVI
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PTH_KINRD
Sequence: MSDAWLVVGLGNPGAEYERTRHNVGQMVLDELASRTRGSFKRHRTGARTAEVRLGVAPGGAPGPRVVLAAPTSYMNVSGGPVAGLAKYFDVDVEHLVVVHDELDVPFGSVRLKRGGGEGGHNGLRSISKSLGDKDYARVRVGIGRPPGRQDPADFVLKEFSSTEKKDMPFLVMDAADAVEELVIKGFEAAQQKFHAPA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_METM6
Sequence: MYGESLVKLMLALDVMDEKKAVLIAKETSEYVDSIKIGYPLVLATGLNIIDKIKEATNKEVICDFKVADIPSTNEKIAELTLNHADGIICQGFVGSDSVSAILNVGKAKNKKVIMVTEMSHPGATEYLQNVAEDMAKMADRLKVDGIVAPSTRPERLEEIKSIAKDAFVISPGVGAQGGNLSDVLNVLSENDYVIIGRAIYENENPKEMAKKYRMQM
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: TRMA_ECOBD
Sequence: MTPEHLPTEQYEAQLAEKVVRLQSMMAPFSDLVPEVFRSPVSHYRMRAEFRIWHDGDDLYHIIFDQQTKSRIRVDSFPAASELINQLMTAMIAGVRNNPVLRHKLFQIDYLTTLSNQAVVSLLYHKKLDDEWRQEAEALRDALRAQNLNVHLIGRATKTKIELDQDYIDERLPVAGKEMIYRQVENSFTQPNAAMNIQMLEWALDVTKGSKGDLLELYCGNGNFSLALARNFDRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKSYQCETIFVDPPRSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHKVERLALFDQFPYTHHMECGVLLTAK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: GPI11_DEBHA
Sequence: MPPKLKATRKSVSFQHLSDEDISKSQYILKTEFPRIETSTLTIPFHSALLIFGLYKFGLTNDIYGVMLKGIFSLIPLQLLYGYLITTRSEKEKKTKSHNNSENVPLLLAGGIVISLVLSVPLFVALILLGAPLASHLKETYLLSIHLSLLIFYPSLVLYKYDYKSLVKFLDADGVYNAIAKNQILLSAVLAVIGTWFGVIPIPLDWDRDWQQWPITLLTGAYIGSFVGGIACFLFQ
What is the function of this protein?
Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.
What are the official names of this protein?
Glycosylphosphatidylinositol anchor biosynthesis protein 11.
What is the protein family that this protein belongs to?
Belongs to the PIGF family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YCAR_ECO45
Sequence: MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS
What are the official names of this protein?
UPF0434 protein YcaR.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: NDB4N_TITSE
Sequence: MQIKHLITIFFLVLIVADHCHAFLGMIPGLIGGLISAFKGRRKREITSQIEQYRNLQKREAELENLLANLPVY
What is the function of this protein?
Antimicrobial peptide (PubMed:23770440, PubMed:27917162, PubMed:27567704).  Has a high antibacterial activity against the Gram-positive bacterium S. aureus (MIC=5-17. 30 uM), the methicillin-resistant S. aureus (MRSA) (MIC=17. 30 uM), and E. faecalis (MIC=69. 23 uM) (PubMed:23770440, PubMed:27567704).  Has antifungal activity against Candida spp.  and one Cryptococcus neoformans strains with MICs values ranging from 6. 25 to 100 uM (PubMed:23770440, PubMed:27917162, PubMed:27567704).  Shows also an inhibitory activity on C. albicans biofilms at high concentrations (PubMed:27917162). Has a moderate hemolytic potency (18% at 20 uM) (PubMed:23770440, PubMed:27567704).  Also inhibits the growth of the five human cancer cell lines tested (the squamous carcinoma cell line H157 (IC(50)=4. 1 uM), the lung adenocarcinoma cell line H838 (11. 0 uM), the breast carcinoma cell line MCF-7 (6. 4 uM), the androgen-independent prostate adenocarcinoma cell line PC3 (13. 3 uM) and the glioblastoma cell line U251-MG (15. 4 uM)) (PubMed:23770440).  In the model of polymicrobial sepsis, it exhibits an antibiotic effect, reducing the levels of microorganisms in the infectious focus and the inflammatory responses in the lung and cecum of septic animals (PubMed:27567704).
What are the official names of this protein?
Antimicrobial peptide TsAP-2, Non-disulfide-bridged peptide 4.23, NDBP-4.23.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GBG7_RAT
Sequence: MSGTNNVAQARKLVEQLRIEAGIERIKVSKASSELMSYCEQHARNDPLLVGVPASENPFKDKKPCIIL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.  Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain.  Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7.
What is the protein family that this protein belongs to?
Belongs to the G protein gamma family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: REP_SPV4
Sequence: MACLRPLQVHNLKKGEKVNFKHYSNGDVARYDMNKNYIVNDSVPCRKCVGCRLDNSAEWGVRASLEIKSNPKHNWFVTLTYSDEHLVYNALGRPNCVPEHITKFIKSLRKYFERRGHIGIKYLASNEYGTKRMRPHYHICFFNLPLDDLEKTIDSQKGYQQWTSKTISRFWDKGFHTIGELTYHSANYTARYTTKKLGVKDYKALQLVPEKLRMSKGIGLKYFMENKERIYKEDSVLISTDKGIKRFKVPKYFDRRMEREWQDEFYLDYIKEKREKVAKRTLFQRQIVSSRSYTDYLGDEQKKLNNIVKRLTRPLKTGKK
What is the function of this protein?
Plays an essential role in viral DNA replication.  Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond, generating the dsDNA replicative form II (RFII).  In turn, viral DNA replication initiates at the 3'-OH of the cleavage site.  After one round of rolling circle synthesis, protein ORF2 is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single-stranded molecule ready to be packed into a virion.
What are the official names of this protein?
Replication-associated protein ORF2, Rep.
What is the protein family that this protein belongs to?
Belongs to the microviridae Rep protein family.
Protein: GPDA_LEGPA
Sequence: MNKKTIAMLGAGSWGTAVAIHLAKIGHKTLLWSHNPQHVALMAEQHSNPAYLPGIPFPENLIPSDDLIECVQLADYVIIAVPSHAFAEIINKIPKPTQGLAWLTKGVDPASHQLLSQLVASRFGVDFPIAVISGPSFAKEVARFLPTALTLASNNTNYQKKMHQLFHHDNIRVYLSDDLIGVQLCGAVKNILAIACGISDGLGYGANAKAALITRGLAEMTRLGLSMGARQDTFLGLAGVGDLVLTCTDDQSRNRRFGLLLGREVPIPEAEHQIGQVVEGKHNAAQICAIANKNKVEMPICEQINALLHGIVHAQQAVNNLMSRPAKEE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_XANC8
Sequence: MSEDRQGRSGDSNKILYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREELEEKAQSARSSLPKPREILEVLDQYVIGQLRAKRTLAVAVYNHYKRIESRSKNDEVELAKSNILLVGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQQGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTKNILFICGGAFAGLDKVIQARSNDAGGIGFGAKVKSSERKQEVGKILAEVEPEDLIKFGLIPEFVGRLPVVATLEELDEPALIKILTEPKNAITKQFKKLFEMESVELEFRPDALSAIAKKALKRKTGARGLRTIVESVLLDTMYELPSQENVSKVVVDESVIEHKSEPYLIYQAQPAPAKAASGD
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: PURA_LEGPH
Sequence: MGKNVVVLGTQWGDEGKGKIVDLLTQDAQVVVRYQGGHNAGHTLKINGVKTVLRLIPSGMLRPNVTCYIANGVVLSPQALLSEIKELEGNGINVRERLRISLACPLILPYHIALDKARETHMGKSAIGTTGRGIGPAYEDKVARRALRVGDLFHRDRFANKLTELLDYHNFVLTQYFKQPAVDLESLLGESLQWAEELRPMVCDVSACLHEHRKQGENILFEGAQGVYLDIDHGTYPYVTSSNTCVGSVINGAGFGPRYIDYVLGITKAYTTRVGGGPFPTELLDDVGKRIAERGQEFGAVTGRPRRCGWFDAVLLKRSIELNSISGLCVTKLDVLDGLEVLRIAVAYKDRDGNILSRPPLAADDFNDLLPVYEELPGWQESTADVTVMSDLPANARAYLKRIEEILGIPIDMLSTGPERDSTITLRGPFL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP4AT_MOUSE
Sequence: MAAVPPLRDRLSFLHRLPILLKGTSDDSIPCPGYLFEEIAKISHESLGSSQCLLEYLLNRLDSSSGHVKLKVLKILLYLCGHGSSSFLLILRRNSALIQEATAFSGPPDPLHGNSLYQKVRAAAQDLGSTLFSDAVPQPPSQPPQIPPPAGMGAQARPLSALQGFGYTKESSRTGSAGETFLSTIQRAAEVVANAVRPGPDNPCTKGPLPYGDSYQPAVTPSASHTHPNPGNLLPGAILGARAVRHQPGQAGGGWDELDSSPSSQNSSCTSNLSRASDSGSRSGSDSHSGTSREPGDLAERAEATPPNDCQQELNLVRTVTQGPRVFLSREETQHFIKECGLLNCEAVLELLLRQLVGTSECEQMRALCAIASFGSADLLPQEHVLLLCRQQLQELGAGSPGPVTNKATKILRHFEASCGQQLPTLRLCAQPNSAAAPVGPADLLTSPVPAPGSQVFLQPLSSATVVPRSPVLFPSPNTLPPSALEEPSEVRTQLVCSSEQGTESEQRLENTDTPEDSSSPLPWSPNSLFAGMELVACPRLPCHSSQDLQTDLQKVTTEAPVSEPSAFAFLNM
What is the function of this protein?
Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.
What are the official names of this protein?
AP-4 complex accessory subunit Tepsin, ENTH domain-containing protein 2.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Extensively colocalizes with AP-4 which mediates the recruitment of TEPSIN to the trans-Golgi network.
Protein: SRP19_METMA
Sequence: MKDKGKLVIWPAYIDQTKSRSSGRIISRKNSIKEPHLNEIKEAARQLGLNPEVEPEKAYPKSWWEVSGRVLVDDNGPKSVIAKQIALAIKKMRGQEVPAKT
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_RICTY
Sequence: MSRKCELTGVSVLYGNNVSHSQRKTRRRFEPNLRSVKFRSDITDEVYRLSVNARCIRSVEKAGGFDEYILKANNDVLSSTARAIKQKIIDIKAVESL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: ACKA_FRUSA
Sequence: MSKIIAVNAGSSTLKFKLYEMPEENVLAEGVIERIALPASHVEIKYGDGKKYEKTTDVKNHEQAIQILLDQLLDLDIIKEYSEINGVGHRVVAGGEYFDKSVVITPDVLKKIESLTELAPLHEPANVLGIKAFKKVLPDIISVAVFDTAFHATLPEKNFLYSLPYEYYEKYSARKYGFHGIGNRYVSQRAAELLGKPAEDLKMIITHLGAGASICPVKNGKSFDTSMGFTPVTGITMATRSGDVDPSLLAYVMEKEGMTDINEMIKVLNTKSGLLGISGVSADMREVEAAQATNPRAKVAREIYVNRIIRYVGAYLAEMGGADAIVFTAGVGENSITIRKEVAEGLNYFGIGVDNEKNDVRGVVRDISAKDSKIKTLLVPTDEELMIVRDVQTLANK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_MORAB
Sequence: MLKTILVGATGYTGAELAHYITKHPELELAGLYVSEHSLDAGKPFSSLYGHLLGVVDQTIQPLALSNIKHICDDVDIVVLATAHEVSHDIAAEFLAQGTVVFDLSGAFRVNDPAFYEKYYGFKHNFDKELKSAVYGLAEWASADIAEANLIAVPGCYPTASLSALKPLAQHGLIAAEQKPIINAVSGVSGAGRKASLASAFCEVSHAPYGVFNHRHQPEISTHLGHEVIFTPHLGSFKRGILATINVKLVAGVTPEQVTAAYQEAYQDQPMVRLLPRRTPSIKAVEKTAYYDLAWQQQGQDLIVVSAIDNLLKGAAAQAMQCINIRFGFAMTTSLV
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMC1_YEAST
Sequence: MDRPRTLRTYRGLIRAILKYERPSKIVNWGNLRKAMITKLEYAKKQNQRDSHENINRQLEKWKKLDPVSDRSLNLFIADSKSLRSILQNDIKWEKKVAQGQNVDEIFEHALDIIKFLDNQREYEELVDRYNPGNKLTQDEKVKRTANVVGLDVPT
What is the function of this protein?
Needed for the assembly of the mitochondrial F1-F0 complex at high temperature.
What are the official names of this protein?
ATP synthase assembly factor FMC1, mitochondrial, Formation of mitochondrial complexes protein 1.
What is the protein family that this protein belongs to?
Belongs to the FMC1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TPAV_RANAR
Sequence: LLPLVGNLLNDLL
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Temporin-AV.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.