PharMolix/UniProtQA huggingface dataset:
Protein: PROA_STRPN
Sequence: MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKISDVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTALKKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKALSIINNAKTSRPSVCNAMEVLLVHENKAASFLPRLEQVLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYVLAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPMGLKELTSYKYVVAGDGQIRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_SHESA
Sequence: MAKKIDAYIKLQVKSGSANPSPPVGPALGQKGVNIMEFCKAFNARTEKMEKGMPIPVVITVYSDRSFTFETKTPPASYLLKTAAGLKSGSPRPNTQKVGTIARAKIQEIAELKAADMTGADVEAMTRSIEGTARSMGLVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ATPD_BACCQ
Sequence: MSNGIVAKRYAVALFKIAKEKHVLEMFEEELRLVQNVYVKNGELHSFLTQPNISKEQKKTFLANVFGSVSESILNTLYILIDNKRIDILPEIADEYVVLANEERNVADATVYSTRLLSEEEKLNIAEAFAKRTGKDAIRVKNVVDEDLLGGIKVRIGNRIYDGSLQGKLARIQRELMKNR
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HIS4_ECOUT
Sequence: MIIPALDLIDGTVVRLHQGDYGKQRDYGNNPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEKDVAALLEAGVARVVVGSTAVKSPEMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDINDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_LACDA
Sequence: MRVIFSGGGTGGHIYPIMALIERLKEEGICQDDEILFVGTKKGLESKIVPAAGVNFKTIDIQGFDRKHLLNNVKTIQLFLKATKRAKEILADFQPDVVLGTGGYVSGAIVYEASKMKIPTMIHESNSVVGVANKFLGHYVDKICYTFDDAAKEFPEKKKLVKTGNPRSQQVLSLNAKPVDLAGDLGLNPKIPTVLVFGGSRGALAINRVMLKSLMELKKKPYQVIWATGTYYYDAIEKKLADVDYDDSIKVVPYIDNMPGLLPEMTCVVSRSGATSLAEFTALGVPVILIPSPNVTHNHQMKNAMDLEKAGAALVIAEDDLNENTFVSSIDHLLLDQSYDEKMRQASKALGVPDASDQVIKVMKEIAKKN
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL7_FRASN
Sequence: MAKLSTDELLDAFKEMTLLELSEFVKQFEDTFGVTAAAPVAIAAGPVAGGAGGEAAAVEEQDEFDVILESVGDKKIQVIKEVRALTSLGLKEAKDLVDGAPKPVLEKVAKEAADKAKAALEGAGATVTVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: BDS6_ANEVI
Sequence: MNKALFLCLVVLCAAVVFAAEDLQKAKHAPFKRGAAGAAICICPDKVGRGDLWLFRGDCPGGYGYTSDCYVWPNICCYPH
What is the function of this protein?
Blocks Kv3 voltage-gated potassium channels.  Reduces blood pressure.
What are the official names of this protein?
Kappa-actitoxin-Avd4f, Kappa-AITX-Avd4f, Antihypertensive protein BDS-6, Blood depressing substance 6, BDS-6.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: PIDD1_MOUSE
Sequence: MAAVLEGQEPEETAAAAEDAATSTLEAVDAGPGAPFLPAGNQLNLDLRPGGCHRLQYLCSQQPPQLLQVEFLRLSTHEDPQLLDDTLAKVPWSLLRLRSLVLKGGQSRGALGACLHGTLTTLPAGLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRLDLSENLLDTIPSEIGNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPTGLVHLPLITRLDLRDNRLRDLPAELLDAPFVRLQGNPLGEASPAPPSPPDISQVPEMPRLLLTSDLDSFLVTPHGCSVTLACGVRLQFPAGATTTPVTIHYRLWLPEPGLVSLGPHDFLLSSVLELQPHGVAFQQDVSLWLLFVPPRVRRCREVVVRTRSNNTWNDLETQLEEEAPKRLWARCQVPHFSWFLVVLRPVSNTCLLPPEGALLCSSGHPGVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLSQSGPPSFLQPVTVQLPLPPGVTGFSLDRSHLHLLYRTPLTTTWDDITTQVALEFTHLYARFQVTHFSWYWLWYTTKTCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLSRLLVRYRGPEPSETVEMFEGEKFFAAFERGIDVDADRPDCVDGRICFVFYSHLKNVKEVYITTALDREAQDVRGQVSFYRGSLPVEVPAEAEAARQRKGTDALWMATLPIKLPRLRGAQGSGQGTDFSLMPLNLGDAETGFLTQSNLLSVASRLGPDWPAVALHLGMPYHKLQRIRHEFRDDLDGQVRHMLFSWAERQTGQPGAVGHLVQALEQSDRRDVAEEVRAILELGRHKYQDSIRRTGLAPEDSTLPGTSASQTPESAQA
What is the function of this protein?
Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264).  Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis.  Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (By similarity).
What are the official names of this protein?
p53-induced death domain-containing protein 1, Leucine-rich repeat and death domain-containing protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Enriched in the nucleus upon DNA damage.
Protein: Y1882_PSET1
Sequence: MLTTETASNLKVLKRLDVITAECVYGMNIFKDILASLSDTFGGRNKSIQNTLRDARRTALTELRKEAYSLGANAVIGIDLDYSEISGGGKAGMLFIVASGTAVIIEQ
What are the official names of this protein?
UPF0145 protein PSHAa1882.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: Y005_RICPR
Sequence: MKLGFNLDFNELDLTGLKKLDQIFLDYLFKADKSLHKDLMLFRATPLSIIPQDYSKFLLKISPHLDDFLAELFCISKEVTISRLKHKDFDIIYECKRKFVQRVAVKKYPLEKIKDIDFEDVYLKITNLIGTNFTSREFAKQIVIWQQDEESFSLELDIAARYAAYRVFSYYNSLSSWNKNLFLQNDILFNLQQKLDKKNLIDDKKILKYQKNERVDFDYKDSFFNLDEALNNSHYCIYCHKRDKDSCSKGFDVIPHFDRVISVDKIPRLSYRMTTGCPLKQKISEMNYIKAQVLI
What are the official names of this protein?
Uncharacterized protein RP005.
Protein: HDGF_RAT
Sequence: MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCAEEPEVEPEAHEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGMLKRRAGDMLEDSPKRPKESGDHEEEEKEIAALEGERPLPVEMEKNSTPSEPDSGQGPPPEEEEGEEEAAKEEAEAQGVRDHESL
What is the function of this protein?
Acts as a transcriptional repressor (By similarity).  Has mitogenic activity for fibroblasts (By similarity).  Heparin-binding protein (By similarity).
What are the official names of this protein?
Hepatoma-derived growth factor, HDGF.
What is the protein family that this protein belongs to?
Belongs to the HDGF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted, extracellular exosome. Note=Secreted by exosomes and is located inside the exosome (By similarity). May also be secreted as free protein via an as yet unknown pathway (By similarity).
Protein: ADD_PROMH
Sequence: MIDTQLPLTDLHRHLDGNIRPETILDLAQQHNIALPAYELETLRPHVQITKNEPSLVSFLQKLDWGVAVLADLDACRRVAYENVVDVANAGIDYAELRFSPYYMAMKHQLPIEGVVEAIIDGVQSALHTYDVEIRLIGILSRTFGENACQQELNGLLKHQDKITALDLAGDELGFPGHLFQPHFNRARDTGWKITVHAGEAAGAESIWHAIKELGASRIGHGVKAIEDPRLMDYLAEHQIGIESCLTSNIQTSTIASLAQHPLKKFLEHGIIASLNTDDPAVEGIELKHEYTVAAPAAGLTAAQIRQAQINGLTMAFISQAERDALIKKVSLG
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: PRMA_PSE14
Sequence: MPWLQVRLAISPEQAETYEDALLEVGAVSVTFMDAEDQPIFEPELNTTPLWTHTHLLALFEADTNAEMALAHLSLLTGEELPEHSAEVIEDQDWERSWMDNFQPMCFGKRLWIVPSWHAAPQPDAVNLLLDPGLAFGTGTHPTTALCLEWLDGQDLKGCNVLDFGCGSGILAIAALLLGAEQAVGTDIDVQALEASRDNAGRNKIAAERFPLYLPEDLPHQQADVLVANILAGPLVSLAPQLASLVRTGGRLALSGILAEQGEEVAAAYADSFDLDPIANRDGWVRITGRRR
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_BEII9
Sequence: MAVYTHISETDLKTFLASYDIGNALVLKGIAEGVENSNFFLQTERGFFILTLYEKRVEEKDLPFFLGLMEHLSRRGLNCPQPVHNRSGHALGRLAGRPAVIVTFLEGVGADVADARRCAAVGEALARLHQAGADFAGKRTNALGLAAWRPLFETVRDRADTVAPALAATIAEELDFLEAHWPRALPQGVIHADLFPDNVLFRGETLSGLIDFYFACVDAYAYDIAICLNAWCFEPDLTFNIGKGLAFFTGYEHVRKLTAEEAAALPVLARGGALRFALTRLVDWLNVPKGAMVNPKDPLEYMGKLAFHQTVGTVRELGLLR
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: AT1B3_RHIMB
Sequence: MAKEENKSGEQSSSEWKQFIYNPSSGEILGRTASSWALILLFYLVFYGFLAGLFTLTMWVMLQTLDDSVPKYRDRVSFPGLMISPKSAGLEISFSKSDKSHMKSILKFFTHFYHHTMTPYKLQMCSARKAITTEQEGVEEKKSCQFNRSSLGPCAGLEGNEYFGYNDGSPCVLVKMNRIIGLKPDGNPHINCTSKAENISLQYYPEYGKIDLMYYPYYGKKTHVNYVQPLVAVKITPSNSTGTSEIVLECKLYGSPNLKNNDDRDKFLGRVNFKLEIKD
What is the function of this protein?
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.  The exact function of this glycoprotein is not known.  Some specific sequence of the beta subunit can modulate the activation of the Na,K-pump by extracellular potassium ions.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit beta-3, Sodium/potassium-dependent ATPase beta-3 subunit.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: NRSN1_HUMAN
Sequence: MSSCSNVCGSRQAQAAAEGGYQRYGVRSYLHQFYEDCTASIWEYEDDFQIQRSPNRWSSVFWKVGLISGTVFVILGLTVLAVGFLVPPKIEAFGEADFVVVDTHAVQFNSALDMYKLAGAVLFCIGGTSMAGCLLMSVFVKSYSKEEKFLQQKFKERIADIKAHTQPVTKAPGPGETKIPVTLSRVQNVQPLLAT
What is the function of this protein?
May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth.  May play a role in neurite extension.  May play a role in memory consolidation (By similarity).
What are the official names of this protein?
Neurensin-1, Neuro-p24, Vesicular membrane protein of 24 kDa, Vesicular membrane protein p24.
What is the protein family that this protein belongs to?
Belongs to the VMP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, neuron projection.
Protein: FXDC2_HUMAN
Sequence: MKGEAGHMLHNEKSKQEGHIWGSMRRTAFILGSGLLSFVAFWNSVTWHLQRFWGASGYFWQAQWERLLTTFEGKEWILFFIGAIQVPCLFFWSFNGLLLVVDTTGKPNFISRYRIQVGKNEPVDPVKLRQSIRTVLFNQCMISFPMVVFLYPFLKWWRDPCRRELPTFHWFLLELAIFTLIEEVLFYYSHRLLHHPTFYKKIHKKHHEWTAPIGVISLYAHPIEHAVSNMLPVIVGPLVMGSHLSSITMWFSLALIITTISHCGYHLPFLPSPEFHDYHHLKFNQCYGVLGVLDHLHGTDTMFKQTKAYERHVLLLGFTPLSESIPDSPKRME
What is the function of this protein?
Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression.
What are the official names of this protein?
Fatty acid hydroxylase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Multi-pass membrane protein.
Protein: RL10_ONYPE
Sequence: MIKPQLSKKIDSVAVLQEKISTAKTVIVFEYASLPVSSFMQLRRELKKTSCEVKVYPKNIMQRAVTNAKQDDLVTFLKGAKALIISPQELLEPIKTIYNFAKKNKAVKIVSGIVEQKIVSLQEIKTLATLPSKEQMLALLAASMFAPLQHLAIGLNMLVQTKKQENPQQ
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RL14_BURCH
Sequence: MIQTESRLEVADNTGAREVLCIKVLGGSKRRYAGIGDIIKVSVKEATPRGRVKKGEIYNAVVVRTAKGVRRQDGSLIKFDGNAAVLLNNKLEPIGTRIFGPVTRELRSERFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: TRUA_STAA8
Sequence: MRILVEIAYQGNNFLGFQIQQNGRTVQQQFEKLLQRMHKRHVRIHPSSRTDRGVHAIQQYFHFDTELNIPMSQWQYAMNRTLPDDIYVNNVVTVDDDFHCRYDCVGKRYRYKVYQAQHRDPFQSGLKTFIPETLDLGKMNRAAQQFIGTHDFTGFCSQKTEVESKVRTLYQSEIVKTDDGFDYIVTGSGFLYNMVRVLVAFLIEVGKGRHEVSDVPKLLESKNRKNVPFTAPAEGLYLEKIYLDENELLKDFGNDIKIHRKKSLQND
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: ZSWM5_MOUSE
Sequence: MAEGGEREELLSPPPISPAKRLCSWPSPQAHHPRGTPGAAGGGAGGGGGGCLAPGARPHLQPESLLDCAAKTVAEKWAYERVEERFERIPEPVQRRIVYWSFPRNEREICMYSSFQYRGGPGAGAAAGAAGASPVEEGPPPPPGAAAPAGSAPGAAGAGSSPGLGAGTGTASGGCGGGEGLPFRRGIRLLDSGSVENVLQVGFHLSGTVTEPAMASEPAVTYKVAISFDRCKITSVSCGCGNKDIFYCAHVVALSLYRIRKPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAGASIDDENCWHLDEEQVKEQVKLFLSQGGYYGSGKQLNSMFAKVREMLRMRDSNGARMLTLITEQFMADPRLTLWRQQGTSMTDKCRQLWDELGALWVCIILNPHCKLEEKSCWLQQLQKWSDLDICPLEDGNYGHELPNITNALSQSASHSPDSLSRPRRTVFTRAIEGRELHWQDSHLQRIISSGIYTAPACQRENERLLFNSHGQPLWLEHVPTACARVDALRSHGYPKEALRLTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTITNLEGWVGHPLDPIGCLFLTLTEACRLNDDSYMEMSDMNESRLPVYQHVPVASGCPNSNESYLSLALEVALMGMGQQRVMPEGLYAQDKVCRNEEQLLSQLQELQLDDELVQTLRKQCILLLEGGPFSGLGEVIHRESVPMHTFAKYLFSALLPHDPDLSYKLALRAMRLPVLENSSSAGDTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTLLEAIQKHIHSPSLIFKLAQDAFKIATPTDSSTDGTLLNVALELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEATSIVAATAVSHTTILRLSLDYPQREELASCARTLALQCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELRGYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWACALSHSLGKNELAALIPLVVKSVHCATVLSDILRRCTVTAPGLAGIPGRRSSGKLMSTDKAPLRQLLDATINAYINTTHSRLTHISPRHYGEFIEFLSKARETFLLPQDGHLQFAQFIDNLKQIYKGKKKLMLLVRERFG
What are the official names of this protein?
Zinc finger SWIM domain-containing protein 5.
Protein: FEN_METTP
Sequence: MGVDLGDILSKKKISLENLSGCWIAVDGFNTLYQFLSIIRQPDGTPLMDASGRVTSHLSGLLYRMTNLIEVGIRVAFVFDGTPPELKAGTLAARAQMKEAAEIQLQEAIATGVDSFRYAQATARINSEILHDSIRLLDAMGIPYVQAPSEGEAQAAFMAIRGDVDYVASQDYDSLLFGAPRVVRNLAITGRRKMPRKNIYIDVPPEVIILEEELTRLGISREQLIDIGIMCGTDYNRGLPKVGPKRALKLIREHGCLEAVLDALGESIENFREIRELFLHPAVTESYELRMRKPMVDEIVGFLCNERNFSEDRVRKAAERLNASYRSGQSTLERWL
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: TRPD_ANAD2
Sequence: MIQQAIAKLLEGEDLTRAEAALVMTEIADGGATPAQSGAFLAALRMKGETVDEIAGAADVMRQRADRVRVDRDVFIDTCGTGGDGRHTFNISTTAAFVAAGAGVCVAKHGNRAVSSRSGSADVLAALGVNVDADKETVERCIEEVGIGFLFAVRLHPAFKAIAGVRRELGVRTIFNLLGPLANPAGARHQVLGVYEARWVPVLGGVLAALGAAHAFVVHGEGLDEIAVTGMTHVCEVRDGQVERYTIRPEDLGLPRRDAAELVGGDAVANARIVTDVLEGQAGGPRDAVLANAAAALVCAGAAKDLRDGVARAARSIDSGAAREKLRQLVAATTVPA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: ELO3_CAEEL
Sequence: MAKYDYNPKYGLENYSIFLPFETSFDAFRSTTWMQNHWYQSITASVVYVAVIFTGKKIMEKYKPFQLDTPLFVWNSFLAIFSILGFLRMTPEFVWSWSAEGNSFKYSICHSSYAQGVTGFWTEQFAMSKLFELIDTIFIVLRKRPLIFLHWYHHVTVMIYTWHAYKDHTASGRWFIWMNYGVHALMYSYYALRSLKFRLPKQMAMVVTTLQLAQMVMGVIIGVTVYRIKSSGEYCQQTWDNLGLCFGVYFTYFLLFANFFYHAYVKKNNRYTEVKKDKKEKEEPVDFEILEPKEDINANIAEPSITTRSAAARRKVQKAD
What is the function of this protein?
Could be implicated in synthesis of very long chain fatty acids (By similarity).  May be required for normally rapid growth.
What are the official names of this protein?
Putative fatty acid elongation protein 3, 3-keto acyl-CoA synthase elo-3, Very-long-chain 3-oxoacyl-CoA synthase 3.
What is the protein family that this protein belongs to?
Belongs to the ELO family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MO2_MOROL
Sequence: MAKLSFLSLFLLCLVATATAQNCGRQAGNRACANGLCCSQYGFCGSTSEYCSRANGCQSNCRGGGGAGGAGGGAGGGSP
What is the function of this protein?
Chitin-binding protein which functions in defense against chitin-containing fungal pathogens.
What are the official names of this protein?
Morintide mO2, 8C-hevein-like protein.
Protein: OXYE_STRRM
Sequence: MTGHPRPPADGAHTDVCVVGGGPAGLTLALLMLRSGARVTLVERSRSLDRAYRGEILQPGGQALLDALGVLEGARRRGCHEHDGFRLEERGRTLINGDYRRLPGPYNCLLSLPQQHLLTDLLERCRAHPRFTCLTGTKVNGLVEEGGVVRGVVCGGGADGLVVRADCVVGADGRYSTVRKLAGIPYDRIELFDQDVLWCKLTAPATRTVRIFRAGGNPVLAYTSFPDCVQLGWTLPHKGYQALAERGFAHVKERIRAAVPEYADTVDQQLNSFKDVSLLDVFAGSARRWARDGLLLIGDSAHTHSPIGAQGINLAIQDAVAAHPVLCEGLRRRDLSERFLDAVAARRRPETERATRVQVMQSRMMLSTGRVSAAVRPKAAMLVSRTPAYRSVLRRIAYGDQTLRVRSDLFEEGEPATV
What is the function of this protein?
Involved in the biosynthesis of the tetracycline antibiotic, oxytetracycline.  Catalyzes the C-4 hydroxylation of 6-methylpretetramide to yield the intermediate 4-hydroxyl-6-methylpretetramid, which is subsequently hydroxylated by OxyL to yield 4-keto-anhydrotetracycline.  OxyE serves as the ancillary enzyme to assist OxyL in the hydroxylation of C-4.
What are the official names of this protein?
6-methylpretetramide 4-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: MURI_HERA2
Sequence: MKDQPIGMFDSGVGGLSTLRDLRALLPHEDIIYYADTGNCPYGGRSHEEIVALSERITYILLERGVKLIVVACNTATLHAVDYLREHFSISFVGMEPGIKPAIAQTKTGVVGVMATQATVAGERFQRLIARYAGDVQVVPQACPGLVELIEAGELQSETTRDAVARYVAPLLKAGADTIVLGCTHYPFLRSLIADVAGPNVALLDTGAAVARQTQRLLAAADLLNPQTSQGSIEWLTSGDPAHFAKIRQCLEIE
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: CBPM_SHISS
Sequence: MANVTVTFTITEFCLHTGISEEELNEIVGLGVVEPREIQETTWVFDDHAAIVVQRAVRLRHELALDWPGIAVALTLMDDIAHLKQENRLLRQRLSRFVAHP
What is the function of this protein?
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA.  Together with CbpA, modulates the activity of the DnaK chaperone system.  Does not inhibit the co-chaperone activity of DnaJ.
What are the official names of this protein?
Chaperone modulatory protein CbpM.
What is the protein family that this protein belongs to?
Belongs to the CbpM family.
Protein: SUEX1_CAEEL
Sequence: MQSLLVFCLATIILSNFTEASADLETASQSLKHPRNLGWKAPEGHREKRYGGWGGGYPYGGYGGYGGGYGGGYGGGYGGGYGGRYGGNYGSSSWGSYSSYSSGGYSSYNSGFW
What are the official names of this protein?
Protein suex-1.
Protein: RNY1_YARLI
Sequence: MQFSLATIATVAAAVSALVCPYTKRDAVAAFTSPPLSSADHKSCPADTPVSCSSGAGSADLCCTESPGGVLVLTQFWDWTPAIGPDDLFTLHGLWPDNCDGSYAQFCDKSMEVQSVAAVLQQLGETELLDKMNKIWIPNRGSTDSFWTHEWNKHATCMSTLKDKCYSSDAPQYQSLADWAHTVVNVFETVNTYKFLEAAGITPDSSKTYAKTDFLNALNSNFDGKQVHISCKSGYISEVWYYFHLKGSVVSGQYLPIDDIGSSSCPDQIKFPPKDGSGGTPPPTDPSDPPTGGSKGFINISGQSGCLISNGNWYTSGTCATYTLGESQYGGVTLTSSKGPCDVVNGKFSCASGNNAGQFTQDGSNIVYGGKSDWSAPSVPSGSQQVGVSPGSAGGSVSFNLVFAAK
What is the function of this protein?
Rnase which modulates cell survival under stress conditions.  Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death.  Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration (By similarity).
What are the official names of this protein?
Ribonuclease T2-like, RNase T2-like.
What is the protein family that this protein belongs to?
Belongs to the RNase T2 family.
What are the subcellular locations of this protein?
Vacuole lumen. Cytoplasm. Note=Is released from the vacuole to the cytoplasm during stress conditions like oxidative stress or stationary phase stress.
Protein: RL29_ROSCS
Sequence: MKADELRKLDNEQLRAKLKDCYEELFNLRFQQVMGKLTATGRPRMVRRDIARIKTILRERELGIES
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: THIG_ANOFW
Sequence: MLQIGPYTFQSRLLLGTGKYPNIDIQKEAVEASGAEILTFAVRRMNIFAPDQPNFLEKIDVTKYKLLPNTAGAKTAEEAVRIARLAKASGLCDMVKVEVIGCDQTLLPDPVETLKATEMLLEEGFIVLPYTSDDVVLAKRLQQLGCHAIMPGASPIGSGQGIINPLNIQFIIEQATVPVIIDAGIGGPADAALAMELGADGVLLNTAVASAKDPVKMAKAMKLAIEAGRLGYEAGRIPKKKYATASSPSEGMSIV
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.