PharMolix/UniProtQA huggingface dataset:
Protein: TJB14_HUMAN
Sequence: TNEKLFFGSGTQLSVL
What is the function of this protein?
J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta joining 1-4.
What are the subcellular locations of this protein?
Cell membrane.
Protein: DEF_THERP
Sequence: MAVRTIITEGDPRLRQKAIRIRVVDEEVRQLARDLWDTVRAARGLGLAAPQIGVLRRIIVVAIPPDYVEEGDPGVELTLINPEIVRASGRQVGLEGCLSIPGWYGEVPRSMHVTVKALDLDGREVRVKGSGLLARVLQHEIDHLEGILFVDRIEDRSTLRYIPDEEEETAEAATGT
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RUVC_DEIGD
Sequence: MIVLGVDPGLANLGLGLVEGDVRKARHLYHVCLTTESAWLMPRRLQYLHEEVARLLAEYRPDAVAIEDQILRRQADVAFKVGQAFGVVQLACAQAGVPIHAYGPMQVKRSLVGTGRADKEQIIYMVKATLGIRELFNNHAADALALALTHLAHQPMRAASTRLAQKSA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RHLB_ECO7I
Sequence: MSKTHLTEQKFSDFALHPKVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTSTFHYLLSHPAIADRKVNQPRALIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMYDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELAFEQMNNAEYIEVEPEQKTGHRIKEELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILDEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGHSIPVSKYNPDALMTDLPKPLRLTRPRTGNGPRRTGTPRNRRRSG
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_CHLAB
Sequence: MTKEVKQLFGTDGVRGKANYEPMTVELSVLLGKAVAGVLQESKSGKHRVVVGKDTRLSGYMFENALVAGLTSMGIETLVLGPIPTPGVAFITRAYRADAGIMISASHNPYWDNGIKIFSSEGFKISDVIERRIEQMVALKEFGNFPDDCAVGKNKRVVDAMGRYIEFAKATFPRGRTLKGLKIVLDCAHGAAYKVAPSVFEELDAEVICYGCEPTGSNINDNCGALFPSVIQKAVIEHKADVGIALDGDGDRVIMVDEKGHIVDGDMILSICANDLKKKDLLRGNRVIATVMTNFGVLKYLESVGIEALISPVGDRHVLQNMLEYEVNLGGEQSGHMIFLDYNTTGDGIVSALQVLRIMIESESTLSDLTSLIVKSPQALINVAVKEKIPLDTLPLVQEALRDVRSSLGDSGRVLLRYSGTENICRVMVEGLKKHQVDSLAKTIADIVDSELGVGMVE
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MIAB_CHLPM
Sequence: MKHEKGRSFYIHTFGCQMNQADSAIITAILMDGGFRVAGSQEDADIVILNTCAVRENAVERITHQLQFLRGAKRRKKSLLVGVAGCVPQHLKREMLEMFPVIDFLAGPDTYRNLPALIGDAEEGKRPAALEFRIEETYAGIDPLREVGVGAFVPVTRGCNNMCAFCVVPFTRGRERSQPFSAVMDEVRRVVEKGYGEITLLGQNVNSYADPEEGRDFASLLRAVSREAPGCRIRFTTSHPKDISPDLVDAIADSPNICNHVHLPVQSGSSRMLHRMNRGHGIDEYLETVALLRRRIPGVSLTTDLIAGFCGEEDEDHEATLALLREVRYDNAFMFYYSPRFGTAAWKTLADTVPLAVKKQRLQEIIDLQLSISAECLQEAVGSVVDVLAESESRRSTEQLMGRTGTNRAVVFDRGGARPGDRVSVLISKASSATLTGVNQGVLPAFYS
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHA7_MACMU
Sequence: MRCSQGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPSGEWDLVGIPGKRSEKFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGMHCAPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  The channel is blocked by alpha-bungarotoxin (By similarity).
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-7.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=TMEM35A/NACHO and RIC3 promote its trafficking to the cell membrane.
Protein: TIG_NATTJ
Sequence: MSSTWEKIDKNKIKLSVEVDENRVEDALEQAYKKVVKQVEIPGFRKGKVPRKILENRFGPEVLYEDAIEILVPEAYQEALEEHEIEPVDQPEIDIDQMEKGQPLKFNATVEVKPEVELGTYKGLEVEKEKVEVTEEDVENELKQMQEQHAEYEDVEDGEAENGDRLVIDFEGYVDGEPIEGGQAENHNIELGSNQFIPGFEEQLVGSKPGEEKEVKVTFPEDYQNEELKGKEATFNVKVKEIKKKNLLPIDDEFAKDVSDFDTLEEFKNDIRNRLEEEAERAAEQQVEEQVVTKALENAEVEIPQPMIDQEVDNMLKEFEQNLSYQGLNLDTYYKLANTDEDAMKEQFKGSAETRVKRNLVLEAIKDEEGITATEEEIDEEINKIAEQAQQEADKIKEFLEMQGRMSQLKNEIAIRKSVDLLKDEAKVTVVEKSNDSEEETQGNTE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: MIAA_LEGPL
Sequence: MNKLVFCLMGPTASGKTGLACELLTHFPFEIISVDSAMIYRDMNIGTAKPSIHELQSAPHYLIDIKDPVESYSAAQFCTDALSLCAAIIKRGNIPLLVGGTMMYFNALQKGLATLPEADEAVRKRLEEEALSQGWDFLYQKLSQLDPVTAARIHAHDTQRIQRALEVYYLTGSTLSTYLTGPHEQPDYCFVNLALFPEQRSWLHERIAQRFDAMLSEGFIEEVQQLQAKWPIQINLPSMRCVGYRQILEYLAGHYDYETMREKGIAATRQLAKRQLTWLRHWEGALFYDSQNVGFNTDIIAKIREILDNTVSN
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: TIM8_NEUCR
Sequence: MDIPQADLDLLNEKDKNELRGFISNETQRQRVQGQTHALTDSCWKKCVTSPIKTNQLDKTEAVCMADCVERFLDVNLTIMAHVQKITRGGSK
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.  The tim8-tim13 complex is non essential and only mediates the import of few proteins, while the predominant tim9-tim10 70 kDa complex is crucial and mediates the import of much more proteins.
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim8.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: TAZP_ASPTN
Sequence: MSILKLVKGVLYGEGEHHEKPKKTHIVIIGAGLTGLLLAQGLRKLNARLEAEGQSAPFTFSIHERDESSFYRGGGFSLTIHWALQQLYDILPEELSARIFECVGNPDAIKNGQMGSFTFLNLRTGEPALKTTIPPGWKGARMSRVRFLQLLMTDLDIHYSHRLSQITFPTDNTVRAHFENGDQETGNLLIGADGANSVVRRFVYGAENSKNTQLPIRMLNCRSEYPLEELEACLRVDPHLFHAGDPVQDGYFMFAFLDMPPAGSKNGKAGVQLTISWPYESGYLGQEAPSDPPTELPEQLAWLKHMAKHWANPVHDLIYGMPDDSIVRVIRVQEWMPNDANRRPTDGRITTVGDAAHLMTSFRGENANHGVVDVAKLLALLAPSGNKPTDLREVPVPVSTDDA
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of azaterrilone A and other azaphilones, a class of fungal metabolites characterized by a highly oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of bioactivities (PubMed:35398258).  The first step of the pathway begins with the non-reducing polyketide synthase tazA that assembles one acetyl-CoA starter unit, five malonyl-CoA units, and catalyzes a series of Claisen condensations, methylation, PT-mediated cyclization, and finally releases the first hexaketide precursor through the R-domain.  The tazA product then undergoes reduction on its terminal ketone and the following pyran-ring formation by yet undetermined enzyme(s).  Dehydration and enoyl reduction, possibly involving the trans-enoyl reductase tazE leads to the next intermediate.  TazD is predicted as an acetyltransferase and might catalyze the acetylation steps leading to the synthesis of azaterrilone A.  Azaterrilone A is not the final product of the taz pathway and both the highly reducing polyketide synthase tazB and the dual enzyme tazHJ catalyze late steps of the pathway, leading to the production of the 2 final stereoisomers that contain additional polyketide modification whose structures have still to be determined (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase tazP, Azaphilone biosynthesis cluster protein P.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: COBQ_CLOB6
Sequence: MAKIMIQGTASSVGKSLIVAALCRIFKQDGYSVCPFKSQNMSLNSYITLDGKEMGRAQVLQAYAAGLEPEVYMNPILLKPTSDKKSQIIVNGKVYGNSTAMEYHNLKIKFKGMLKEQFKKLEEDFDIVVMEGAGSPAEINLRDRDIVNMGMAEIVDAPVLLVGDIDKGGVFASLAGTMLLLNEGEKERVKGTIINKFRGDVEILNPGLDMLEDIIHIPCLGVVPYTRLQLEDEDGAVEFNKKAYAPIDIAVIKMPHISNFTDLDALKSEEDVSIRFITSKEEFKEPDLLVIPGSKNTIEDLLYLRKCGLEESIKEYSKDGKIIGICGGYQVLGSKIKDPYKVETDLGEIEGLNLLDMETTFEKEKITTRVSAKLINEEIENIVYGYEIHMGISEYSENVKPLFKIYDKNGEKVDYFDGAINEKGNVMGTYIHGVFDGIVFREKIINELRVKKGLKKKKSQVYEHMREKELDKLADIVRQSLDMEKIYSIIGMK
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: CLCE_DICDI
Sequence: MTRKENEESESLSSSSSPIDNSNNNNNNNNHSIFNPIGHIQNAFNNIDLNPLNVDFKGHTDKVVNFFQHGTGDLNDRMQGVVSKLRSNEYRKKMHSVLTKIKDTKEYKSTSNTDYDVIFESVDMYSNLQQDPTMDKDEIDVVTDLSSYKKKFTHWLGKERISTLLFIPTLGILIALMGILCDFLLMELGTLRDFVTSRHNSHVIPTDGTTPTPNSSIADKYDLVEGIVFVGYSVFFALISVCCISFISPYAVGSGIPEMKSIMSGINLSRVLGFKTLVSKIVGMVCASAAGLTIGRTGPFMHASAIISQMLMNLKVFGAIKKNQIVRYQMLICALTSGVVANFGAPIGGLLFAIEVTATTAVMGNLWKGFLCATTTAIIFFLSRSTFSKGNFHSVYEFEFVPKEYGVADLITFVGIGIITGLIGAFFVFIYEKLVRFRLRYPILKQSRIILVLVVSLFSAIITYSAGPLCRVSLPTAMKQFLGQNEPKPFLFEQDQTPYYKYLNLLVFIVVKLILTAFNIVLPIPGGAITPFIVTGAALGRLFGEILKDHFDSQAIEPAGFAAIASAGLVSGTIRNISPSIFVLELTGQLSLLVPILICSITSTAVGNFFNRPLFDTALKIQGLPFLSNYRSSKVYTMTAKQVMKKNINYLSMTSTVIEMKNFLDTFKYTFIPIVDSKENMLLVGIVERSSMIYMLDIHIENIEQKIDEFKSKYFVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNSENLEIENTGAILNTNSNNNNSDEEDYDRKDNDKISLIKPNQDESSSNSNGGSSSDFEEILNTQNTNINKNDNEDLIKEIEDENSSLGEKPIIEHDDEDDDEEEGDGIPLVSMKDQQPVLRNRHTTTTTTTTTTTPITENIYVNDAFEISINDLKNGGQSVWGKHILGDIIHSGETALLMDLAPSQVPDLTPLNKVFHLFTMLGLGFTYVTSLGKLVGVITKNSLMEQDL
What is the function of this protein?
Voltage-gated chloride channel.  Chloride channels may have several functions including the regulation of cell volume, membrane potential stabilization and signal transduction (By similarity).
What are the official names of this protein?
Chloride channel protein E.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: JAZ7_SOLLC
Sequence: MDSRMEIDFMDLNSKPKLSEMEKQHKKVSGMKWPFSLADLATHHEHTFFQNYKSTPIVSINSKNSSLNNYKSTIDPQYFRGTFPLLAKTSTYDSRKNYDNLSPNESTLTIFYMGEVHIFPGISPEKAELIIDLVSKSTTLHMDEILEKVMNKEKYEENKSDPSNASTNYAKGALAMARRATLARFLEKRKHRLIKARPYLYGENLSKFPFDIQQQEEETASSSVHWEN
What is the function of this protein?
Repressor of jasmonate responses.
What are the official names of this protein?
Protein JAZ7, Jasmonate ZIM domain-containing protein 7, Pto-responsive gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the TIFY/JAZ family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTGA_SALA4
Sequence: MSKRRIAPLTFLRRLLLRILAALAVFWGGGIALFSVVPVPFSAVMAERQISAWLGGEFGYVAHSDWVSMADISPWMGLAVIAAEDQKFPEHWGFDVPAIEKALAHNERNESRIRGASTLSQQTAKNLFLWDGRSWLRKGLEAGLTLGIETVWSKKRILTVYLNIAEFGDGIFGVEAAAQRYFHKPASRLNMSEAALLAAVLPNPLRYKANAPSGYVRSRQAWIMRQMRQLGGESFMTRNQLN
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL27_SULSY
Sequence: MASKASGGSTRNGRDSISKRLGVKRYDGQVVRAGNILVRQRGTKIYPGKNVGMGKDYTLFALIDGKVKFETSKGKKVVSVYPVET
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: NADK_STRPF
Sequence: MMTQMNYTGKVKRVAIIANGKYQSKRVASKLFSVFKDDPDFYLSKKNPDIVISIGGDGMLLSAFHMYEKELDKVRFVGIHTGHLGFYTDYRDFEVDKLIDNLRKDKGEQISYPILKVAITLDDGRVVKARALNEATVKRIEKTMVADVIINHVKFESFRGDGISVSTPTGSTAYNKSLGGAVLHPTIEALQLTEISSLNNRVFRTLGSSIIIPKKDKIELVPKRLGIYTISIDNKTYQLKNVTKVEYFIDDEKIHFVSSPSHTSFWERVKDAFIGEIDS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_RUTMC
Sequence: MAHTVQTLSKLLKKTPDEVITILANAGVDGKNSDSAISAEERKILMSSLSKRSSSKSSMFSFSKTGIKSSANSASGAKVQVKKKRLTKSATATDEQPEIAVNEVAQAVQVALDAGRDADKKLLAQDAKRLEMVRLQKTQAEVLKAQKKTVKQAQAQEIEKKAEKPKMIDKFKEDKKPKRLRNTLNGNNTRRQLHVARHNPNRKLKKKDRTRLSQKVQEEQAQHAFQKPIEKVVHEIAIAENIKVTELAQKMATKAGEVLKVLMGMGVMATLNDVIDQDTAMLVVEEMGHKSIASVEETVEDVLIEQLKSSGNEKARPPVVTIMGHVDHGKTSLLDYIRQAKVTHGEAGGITQHIGAYQVQSNGNTITFIDTPGHAAFSKMRSRSANATDIVILVVAADDGVMPQTIESIKHVQTAGVPMIVAINKIDKEGIDIDKIKQVLSTHNVISEDWGGDVMMIPVSAYTGEGVDALLDAISLTAEVLEFSAVIKALARGTVLEARLEKGRGKVTTILVQSGTLNKGDIMIAGFEYGKVKQIVDDKGKVLKSATPSMPVEVLGLSGVPNSGDEVLVVDSERKAREVADFRKAKNREAQLQKQQASKMENFLMKMEESNVSTVNVLLKADVRGSAQALIEALEGLSTDEAKVKVVSSGVGGINNTDITLAATSNALVLGFNVRADAVARKTADNEGVRIEYYSIIYNLIDDVKTIMSGLLSPELSENIIGIASVKSVFRSQKMGDIAGCMVEEGVVRRDSLIRVLRDSVVIFEGWLESLRRFKDNVNEVKSGTECGIGVLNYTDIQPGDQIEVFERIERIRTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_ANAD2
Sequence: MNPLTRVALAVAAFAALVLALSACGPAHVAGHVPKRRDYAVPDAAGQEAQVASAGSTWREGRAASMLYTDARALRENDLVVVRIEEIADAKRSADTDLTRRSELNASIEAFLTSLDTPYALKGGATTGFKGLGSTARTERLTATVPAVVRKVLPNGNLFIEGHRVVLVNAEEQHFYISGVVRPIDIDQENGVKSSMVADAEIEFTGRGVLSDNQRQGWLSRLLGWFWPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: Y149A_MYCGE
Sequence: MTVYTYTVFLFNWENIGLMEQQNPDRLKKDRELIYAIVTAKGIISRFFWSILSFLITNLIFFFAAFVALLIYLLASVDNQFAFVFIAAIIFIIFYNIFFLSYLLFIYFKGQKAIENNCKYLLTILDIKSDELLPFSLLGSLRKGYMLDEMLLEQ
What are the official names of this protein?
Uncharacterized protein MG149.1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYGA_ECOLI
Sequence: MQKFDTRTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTCLRELGPEPMAAAYVQPSRRPTDGRYGENPNRLQHYYQFQVVIKPSPDNIQELYLGSLKELGMDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLVWSDGPLGKTTYGDVFHQNEVEQSTYNFEYADVDFLFTCFEQYEKEAQQLLALENPLPLPAYERILKAAHSFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCNKDK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPPA_SODGM
Sequence: MIRATSLYAAIDLGSNSFHMLVVREVAGTLQTLARIKRKVRLAAGLYGDNRLSSDAMQRGWQCLRLFAEHLQDIPPTQVRVVATATLRLATNAAEFLGPASAILGCPVQVISGEEEARLIYQGVAHTTGGSDERLVVDIGGGSTELVVGRGAQALELFSLEMGCVTWLERYFNDRSLTRENFERAEQAAREKIRPVAFRLLAQGWQVCVGASGTVQALQEIMVAQGMDEHITLSKLLQLKQRAIHCGKLEELEIEGLTLERALVFPSGLAILLAVFAELGITTMTLAGGALREGMMYGMMALPVGGDIRQRTLENLQRRYQLDTEQAQRVTWLADGFARQVAEAWQLDERCFTLLRCASMIHEIGLSIDIKRAPQHAAYLVRHTDLPGFTPAQQKLIATLLQNQSNHINLTQLNEQNCLAPRIAQRLCRLMRLAIIFASRRRDDALPAVELRAAEETLYVILPQGWLSQHPLRAEYLEQESQWQSYVHWPLLLEETSQV
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: RIPL2_MOUSE
Sequence: MEDHPVREEEDGEEDEGALAKSPLQLTTDDVYDISYVVGRELMALGSDPRVTRLQFKIVRVMEMLETLVNEGSLAVEELRMERDNLKQEVEGLRKAGVSGAQVNLGPDKMVVDLTDPNRPRFTLQELREVLQERNKLKSQLLLVQEELQCYRSGLLPPRETPGGRREKDAVVAMGNGEKEERTIMKKLFSFRSGKHT
What is the function of this protein?
Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity).  Plays a role in cellular protein transport, including protein transport away from primary cilia (PubMed:23264467).  May function via activation of RAC1 and PAK1 (By similarity).
What are the official names of this protein?
RILP-like protein 2, Rab-interacting lysosomal-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the RILPL family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.
Protein: PAFA_CORK4
Sequence: MSADKAVFTRRIMGIETEFGITCTHDGAQAVAPDDIARQLFRPIVDRFRSSNIYTLNGGRLYLDVGSHPEYATPECDSLNQLLIYDRAGEVTLNRLADQAEHALADQHIEGTVHLMKNNTDSLGNSYGCHENYLVGRAILLKKLGQEFIPFLITRQLICGAGHIARPHSRFSDGDTTPVYQLSQRADHVWEGVSSATTRSRPIINTRDEPHADSEMYRRLHVIVGDSSMSETTAALKIGSALLVLEMLEAGCSFDEWEIANPSKTIRDISRDLTGRAEVPLRSGRISCALEIQQAFAEKAQQWLDERPEEQHGTPNADMQRVVDLWKKVLAAIDSGDTSSIEADIDWVIKKNIIDRYQDKFGWDLTHPKLQQIDYAYHDIRPGKGIFRTLEERGRVSRWLDGADSSITDAADTPPQTTRAKMRGDFLRVAQENDADVSVDWTRLKINRPEPHDIALLDPFAAHDSRADDMISSILDR
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.