PharMolix/UniProtQA huggingface dataset:
Protein: CNSN_PENEN
Sequence: MRPLPTGIYTPLPCFFHENEDIDIEALQSHVKFIASAGTIPVVSGSMGEAIHLNREEKKTIIRSARVALDEVNLHDVPIVAGAGGASTRESIELCKDAAEAGADYVMVIPPGYYAGALLADTSSIKKFFVDIAEASPLPVIIYNFPAVSGGIDMDSDLIVQIIQSSANICGVKLTCANVGKLTRIMAQVSRPEFQAAFPRSSATPFRAIDGFIDFLLPSISVGSAGAISGLPNIAPKSCVKLWNLCQDSGSSKQATELQNLIALADGVALKIGIAGMKKLLHRHFGRKVACDMPNGPPCLRCTNKYQECTFEEGPGPRKRARLCEQTETFGTCEQPDGWQDLLTETRPNIGQSEDLEAVSPQGSLLGANQELESTSPRTSHSSLSQDDTASLHSRSSLSSSPGRFPPSQKLVATSDSPSQINSLEFIPDAFSFYIGPTGVTDIHILSHQKYNDQNVSLPKVNGLKYRIMDNPGQKEMATVDFSPPTVFGITDHSLLEKAEPKLDPQLTENGWPRLWAMMDPTAAWHLIKLYSRYIDPYFPILSSHQIPSSSAELNKMPLALLTAICATALPFVMYDDSLYTMLLNPPSSEELYRLCWLCISQELHAPSLATLQACLLLQQRLPTNMYLSDTAFAWTLMATSLAVAQTIGLHRDTGSWTSIPAWEKRLRRRLWWGLYAMEKWVALARGMPSHLGDDDYDVSMLKADDIQDTLSDSPDTQSHIYHLSNLSTILSDIQRSFYSVKAIGKTSNDLQYSLDLARPMRVRLKDWRDNLPSNLRPVSNAVISGEDLDGNGSLYLSYIVTHVALLRALLRPLDRWPAIIKVNKEEPEATYEGAKAVVTGALLCVKEFVEFVERLTGAQWNAFWHSWSRPNFAIAGSFMVHLLQIVTPPNQTDSQSMPELLKYSFEKEHTELQDWIRRWRWATRISANGAAGVKGLTNLGFIKVETLIGNGT
What is the function of this protein?
Transcriptional regulator; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals.
What are the official names of this protein?
Communesin biosynthesis cluster-specific transcription factor cnsN, Communesin biosynthesis cluster protein N.
What are the subcellular locations of this protein?
Nucleus.
Protein: CMOA_HAEI8
Sequence: MVKDTLFSTPIAKLGDFIFDENVAEVFPDMIQRSVPGYSNIITAIGMLAERFVTADSNVYDLGCSRGAATLSARRNIHQPNVKIIGIDNSQPMVERCRQHIAAYHSEVPVEILCDDIRHVEIKNASMVILNFTLQFLPPEDRVALLTKIYEGLNPNGVLVLSEKFRFEDTKIDHLLIDLHHQFKRANGYSELEVSQKRTALENVMRTDSIETHKVRLKNVGFSQVELWFQCFNFGSMIAVK
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: NUOCD_ACIBY
Sequence: MAETDIAMPESTPVDSRPAFAIVEELKTKFGENFYVQATFEEFPTVWVERARVQEVLMFLRKVERPYVMLFDLSAMDERLRQHRDGLPASDFTVFYHLLSLERNSDIRIKVALNENDLNLPTATNIWPNANWYEREAYDMFGINFEGHPMLRRILLPTYWEGHPLRKEYSARATEYTPYMQDKAKQDFEQEHLRFVPEDWGLKRGNADEDFMFLNLGPNHPSAHGAFRIVLQLDGEEVKDCVPDIGYHHRGVEKMAERQTWHSFIPYTDRVDYLGGCAQNMPYVMAVEQLAGIKVPERAQVIRVMLNELFRINNHLLYCGTAIQDAGGMTPVFYMFADRQKVYDIVEAITGYRMHPAWFRIGGTAHDLPNNWQKLVKELLDWMPKRLNEYYTAAFKNSVFIGRTRNVAQYDAKSALAWGVTGTGLRATGIDFDVRKYRPYSGYENFDFEVPVEYEGDAYARVLVHFREIEQSLKIIKQCLDNMPSGPYKADHPLAVPPPKDKTLQDIETLITHFLSVSWGPVMPAGEASFMTEVVKGASTYYLTSDKATMSYRTRIRTPTFTHLQQIPSVINGSLVSDLIIYLATIDVVMADVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CCL3_CANLF
Sequence: MKVPGAALAVLLCTMSLCSQVFSPFGADTPIACCFSYVSKQIPRKFIVDCFETSSQCSKPGIIFETRKGRQACANPSEAWVQEYVADLKLKA
What is the function of this protein?
Monokine with inflammatory and chemokinetic properties.  Binds to CCR1, CCR4 and CCR5 (By similarity).
What are the official names of this protein?
C-C motif chemokine 3, Small-inducible cytokine A3.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: SUHB_SALTY
Sequence: MHPMLTIAVRAARKAGNVIAKNYETPDAVEASQKGSNDFVTNVDKAAEAVIIDTIRKSYPQHTIITEESGEHVGTDQDVQWVIDPLDGTTNFIKRLPHFAVSIAVRIKGRTEVAVVYDPMRNELFTATRGQGAQLNGYRLRGSTARDLDGTILATGFPFKAKQYATTYINIIGKLFTECADFRRTGSAALDLAYVAAGRVDGFFEIGLRPWDFAAGELLVREAGGIVSDFTGGHNYMMTGNIVAGNPRVVKAMLANMRDELSDALKR
What is the function of this protein?
Part of the processive rRNA transcription and antitermination complex (rrnTAC).  The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP).  It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis.  This subunit may play a central role in organizing the structure.
What are the official names of this protein?
Nus factor SuhB, Inositol-1-monophosphatase, I-1-Pase, IMPase, Inositol-1-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S12A1_MOUSE
Sequence: MSVSIPSNSVPSSASRFQVHVINEGHGSAAAVGDSADPPHYEETSFGDEAQNRLRISFRPGNQECYDNFLQTGETAKTDTTFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVTVAPGSADRVANGDGMPGDEQAENKEEDMTGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTIVSGMNCNGSAACGLGYDFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELEKLEQERLALEAAIKDNECEEGKGGIRGLFKKAGKLNITKPAPKKDGNISSIQSMHVGEFNQKLVEASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKITRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAEKLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS
What is the function of this protein?
Low affinity, low capacity cotransporter for sodium, potassium and chloride ions, with a coupling ratio 1Na(+):1K(+):2Cl(-).
What are the official names of this protein?
Solute carrier family 12 member 1, BSC1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: VKIL_BPP22
Sequence: MTIVPVNGTILVQQGNREFNKLYEASFPDTKEGNSAAYAWASSIAMGWEDCQDEDWNRNHAA
What is the function of this protein?
P22 kil is essential for lytic growth in the absence of abc.  Expression of P22 kil causes filamentation and cell death.
What are the official names of this protein?
Protein kil.
Protein: DCUP_FRATM
Sequence: MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRAKFDNFMDMCRNADACCEVALHPLQRYDLDAAIVFSDILTIPEAMGMDLKFIKGTGPVFSEPIQSQKDLDKLKSIEDSIGSLDYVYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFNKLRKMMYANPQLMHSLLQRLADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYKEYIAKNVKQKINIPIVFFTKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETVRANIEFIQSDKLNNYIVNLGHGIYPDIDPDSVRVMIDAIREFSA
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_MYCSS
Sequence: MNLAIIAGDGIGPEVIGEAVKVLDAVLPEVEKTTYDLGARRYHATGEILPDSVLEELKVHDAILLGAIGDPSVPSGVLERGLLLRIRFALDHHINLRPAKLYSGVTGPLAGNPEIDFVVVREGTEGPYTGTGGAIRVGTPHEVATEVSLNTAFGVRRVVEDAFRRAQQRRKHLTLVHKNNVLTFAGALWWRTVQEVGAEYPDVEIAYQHVDSAMIHIVTDPGRFDVIVTDNLFGDIVTDLAAAVCGGIGLAASGNIDATRTNPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLAHVGETDAAARVDKAVEAHLSSRGDQELGTAAVGDRIVGLL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTAA_METPB
Sequence: MRLSKAPPADRFDAVPAASDRPGRGAVRAWLYLLAVLVVAMVAVGGATRLTGSGLSITEWRPVTGVVPPLNAADWAVEFDKYRDTPQYRILNQGIGLDGFKTLYWWEWGHRLLGRIVGLVFFLPFAWFWWRGWLGRRLLLGLLGLGLLGGLQGAIGWIMVASGLQPGMTAVAPLKLALHLTTASLILAGLVWLAAGTRALALAPAPEPVRRVAGLLPVLVLIQIWLGGLVAGSKAGLLYNTWPDMDGMLVPPARMLFDKVPFIENFVDNLALVQFNHRLFAYLVVLVALAHAVQAVRMAPGAAAGRAMGVAALTLAQMGLGIVTLLLQVPLWAGLAHQVFAMAVLIMATVHARLSVGVPAASAPTGAAVPIGLEALAGRGV
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OR1A1_HUMAN
Sequence: MRENNQSSTLEFILLGVTGQQEQEDFFYILFLFIYPITLIGNLLIVLAICSDVRLHNPMYFLLANLSLVDIFFSSVTIPKMLANHLLGSKSISFGGCLTQMYFMIALGNTDSYILAAMAYDRAVAISRPLHYTTIMSPRSCIWLIAGSWVIGNANALPHTLLTASLSFCGNQEVANFYCDITPLLKLSCSDIHFHVKMMYLGVGIFSVPLLCIIVSYIRVFSTVFQVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGTYFRPLTNYSLKDAVITVMYTAVTPMLNPFIYSLRNRDMKAALRKLFNKRISS
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1A1, Olfactory receptor 17-7, OR17-7, Olfactory receptor OR17-11.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: F16PA_METLZ
Sequence: MRGSVFGFVPSFRIRFFASSTHIIDTMKTLQEYLSASHAPEDLGKIIMMIADQAGPIRSAFISNQNYAGSTNSSGEDQAEMDTWADTRITSVLQESGLVRSIASEEQEDITEMSPSAKYSVVMDPLDGSSLIKVNLTVGTIVGIYEGDVLQAGNKLRAAFYMLYGPLTTLTISLGNGVSIFAMNEEGTYVLLKENVRIPEGTLCGSGGLRPEWTEKHIQYMNAIECEGGKNRYSGSFVADFHQILEYGGVYAYPATKKSASGKLRLVFEINPIGFLAVQAGGAVSNGESSTLEIVPTKVHQRTPVYVGSKGMIAKIEAIR
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSH_CHESB
Sequence: MAAKPKPLDAEIEALELDARYGHLAAEAIVELAVNRFRDEGGIATVSSFGADSAVLLHMVASVDKSLPVLFLDTGQHFGETIEYRDQLASDLGLSNLVVVHPKSEMLSARDPGNDLHKSDSDLCCEIRKVEPMARAVEPYSAWFTGRKRHQAESRAQMPVFEAVGPRIRINPLARWTTADQAAYMRANDLRENPLVAYGYLSIGCFPCTQPVKPGEDQRSGRWAGLAKTECGIHLPGLEALTNAA
What is the function of this protein?
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
What are the official names of this protein?
Adenosine 5'-phosphosulfate reductase, APS reductase, 5'-adenylylsulfate reductase, Thioredoxin-dependent 5'-adenylylsulfate reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_BACC4
Sequence: MNRLKEKFQKEITPALVSKFNYKSVMQVPKIEKIVINTGVGDAVSNSKALDNAVEELTQITGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGEQMYEFFDKLVSVSLPRVRDFRGVSKKSFDGRGNYTLGVKEQLIFPEIDYDKVSKVRGMDIVIVTTAKTDEEARELLTQFGMPFQK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RSMH_HELPS
Sequence: MQEIESLHQSVLLQEVLQAFAPLEEGVLIDCTLGLGGHSKAILSQKPHLKLIGIDKDKFAQEIAKERLKAFEGRYNLLSGGFAKRFKEALEMHDKEIKGVLVDLGVSSLQLDDDSRGFNFHSHALDMRMDLESDLNAQKVINSYPVVALEKIFKDYGEIKEYKKIAHKIAERRAKKPFKDAKDLSDFLSSLSKNKKIHPATLVFQAVRIEVNSELEELKEFLQCARNLKEAILCVISFHSLEDALVKNAFKDYAKNCICDPSSFKCTCSNNHALGEILTKKPITPSPEEIKNNRRSRSAKMRVFQFKP
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEX32_SCHPO
Sequence: MIRAHLFSEPDNSKLWAKSTGSDAFDLILKVLLWTAPWYYCLTTLFFTWLIILYPRPTLACSVAAWLFWFTSLDTLEPDDRKNTLKASEAVSTSAKTSEETAKPSETREDGEWNTLKNTLEADAQNLMSGFQMLQRRWSQPKTTTLKTEVKEQQASQSPSVEGENEPAGVKSNEATKPSVTEEKEKNAEQNKRRERLSISHIVTELAKKDEVSSESGSNEIVNAKLKNEQLDSNFTLLDAYLEPLVHLHEYSRRSNTLFFFYLPIVMSILIFCLPTQALFIVLSSVFLAWHSPPLQAVLFCIRRISFFNLLYEKFVIGKTKEPAKPVPQPSSNEPPAPSAENKQPSVSSPEKKESPATHLLKVIGSSPYVVHSNHTNNTLTDKESSDPTEKCLYLIEHQRYWVGVGWLNRTLPTDPPNFTNAGSTDPVAEPTAQLLPPDGLAWIDDKWSISPWTFTDTFWAQPAKTQFRTAFTRSREWRRRYRVAPPAENEKPHTSRTNTASSLSSTSEDQVSTHGSISSAKVTAIPDSNGAEAL
What are the official names of this protein?
Peroxisomal membrane protein pex32, Peroxin-32.
What is the protein family that this protein belongs to?
Belongs to the PEX28-32 family. PEX32 subfamily.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: Y1321_STAA3
Sequence: MNAYDAYMKEIAQQMRGELTQNGFTSLETSEAVSEYMNQVNADDTTFVVINSTCGCAAGLARPAAVAVATQNEHRPTNTVTVFAGQDKEATATMREFIQQAPSSPSYALFKGQDLVYFMPREFIEGRDINDIAMDLKDAFDENCK
What are the official names of this protein?
UPF0403 protein SAUSA300_1321.
What is the protein family that this protein belongs to?
Belongs to the UPF0403 family.
Protein: RBFA_MYCTO
Sequence: MADAARARRLAKRIAAIVASAIEYEIKDPGLAGVTITDAKVTADLHDATVYYTVMGRTLHDEPNCAGAAAALERAKGVLRTKVGAGTGVRFTPTLTFTLDTISDSVHRMDELLARARAADADLARVRVGAKPAGEADPYRDNGSVAQSPAPGGLGIRTSDGPEAVEAPLTCGGDTGDDDRPKE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y028_HIS1I
Sequence: MKAKQEIKKIKEFDYDAWIESKELKDIFPPRIMLLWWIGILGMLNYNLVQIVPNSGVALLSVSTFIVGCGLCIGFMLGIEQKKNR
What are the official names of this protein?
Putative transmembrane protein ORF28.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: MET14_BOVIN
Sequence: MDSRLQEIRERQKLRRQLLAQQLGAESADSIGALLNSKDEQREIAETRETCRASYDTSAPNAKRKYQDEGETDEDKMEEYKDELEMQQEEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHRGGFPPR
What is the function of this protein?
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis.  In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core.  N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (By similarity).  M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity).  In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity).  M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity).  M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity).
What are the official names of this protein?
N6-adenosine-methyltransferase non-catalytic subunit, Methyltransferase-like protein 14.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YIDD_PARPJ
Sequence: MQTVLIALLRFYKVAVSPMLGNRCRFYPSCSDYAREAIQYHGAARGTYLAARRICRCHPFSAGGIDLVPPPTSEKR
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: P43_XENBO
Sequence: MQNVGPTEPSKSQVFRCPAAGCKAVYRKEGKLRDHMAGHSEQKLWKCGKKDCGKMFARKRQIQKHMKRHLTLKKHSCPTAGCKMTFSTKKSLSRHKLYKHGDAVPLKCSVPGCKRSFRKKRALRIHVSEHSNEPLSVCDVPGCGWKSTSAAKLAAHHRRHGGYRCSYEDCQTVSPTWTALQTHLKKHPLELQCAACKKPFKKASALRRHKATHAKNPLQLPCPRQDCDKIFSTVFNLTHHLRKVHLCLQTHRCPHSNCTRSFAMRESLVRHLVVHDPERKKLKLKFGRRPSKFLGRGTRCPTPVVEEDLSHLFSRKLLFHYKTRLETNLSGLFNERQLREPAEPEVNLSGLFQLPQGRPKAEKAA
What is the function of this protein?
p43 is a 5S RNA binding protein which is a major constituent of oocytes and comprises part of a 42S ribonucleoprotein storage particle.
What are the official names of this protein?
P43 5S RNA-binding protein, 42S P43, Thesaurin-B.
Protein: RS8_PYRAR
Sequence: MVMLDILSNALIQIKNAEVMGKRQVTIWPVNKLTYYTLRVLQRYGYVGEIEYVDDGRGGKYIVQLLGKINDIGPIRPRYPVKYREIVQWEQKFLPARQIGILVISTSQGVVSHIEAKEKKIGGVLLAYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: DAA11_BOVIN
Sequence: MGRITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEGLTKLDLTVNFIGELSSVKTLQGNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEIERSERIQALQNLPVVEQRIREQEKAYCLKRAKDKEEAQRKLEEEESKGEMGRSHTGSGGHWHADLSATLPSFEESKDYIQAPEIEEGQCKGKEFDDREDDLEFWNKPSLYTPESRLETLRHMEKQRRDQERLSEKKKKVKPPRMLVTEDGRALNVNEPKLDFTLKDDEKRNQIVLDLAVYRYMDTSLIDVDVQPTYVRVMVKGKPFQLILPAEVKPDSSFAKRSQTTGHLVVCMPKVGEVIIGCQRTSKPVKSTPDSSKEQTSKSQQMERLEVDPSKRSIPDVANIVQEKKHMPRRVCAEPKIIPSEEDPDFEDNPEVPPLI
What is the function of this protein?
Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia.  Acts as a crucial component in the formation and motility of spermatozoal flagella.
What are the official names of this protein?
Dynein axonemal assembly factor 11, DNAAF11, Leucine-rich repeat-containing protein 6, Leucine-rich testis-specific protein, Protein tilB homolog, Testis-specific leucine-rich repeat protein.
What is the protein family that this protein belongs to?
Belongs to the tilB family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium. Dynein axonemal particle. Cell projection, cilium, flagellum.
Protein: LENEP_MOUSE
Sequence: MRPPTQPLTQALPFSLRDALRGTGLQVPVIKMGTGWEGMYRTLKEVAYILLCCWCIKELLD
What are the official names of this protein?
Lens epithelial cell protein LEP503.
Protein: Y063_CHLMU
Sequence: MQVLASLFGRSPFSPLQAHVELVSASIEVLFPLFSAIKEGDYQRVEALAQLVSSKERQADGVKNDIRSHLASGVFIPVSRLAMLEIISTQDSVADCAEDIAILLTVKELRFYPEFEEIFFQFLQKTVQSFEVVAKAIREMDLLLESSFGGCRAEKTRVLVNEVSNLEHECDLLQRELMKILFSENFSIETKDFVLWTQIIKRLSGISNNSEKLAYRVGMTLEEK
What are the official names of this protein?
UPF0111 protein TC_0063.
What is the protein family that this protein belongs to?
Belongs to the UPF0111 family.
Protein: EF1A1_EUPCR
Sequence: MGKEKEHLNLVVIGHVDSGKSTTTGHLIYKLGGIDARTIEKFEKESAEMGKASFKYAWVLDKLKAERERGITIDIALWKFETENRHYTIIDAPGHRDFIKNMITGTSQADAAILIIASGTGEFEAGISKEGQTREHALLAYTMGVKQMVVAMNKMDSTEPPYSEDRYEEIKKEVSTFLAKVGYKPAKMNFVPISGFQGDNIQENSTNMPWYKGPTLCAALDSFKIPKRPIAKPLRLPLQDVYKIGGIGTVPVGRVETGVLKAGMVITFAPKGCSAECKSVEMHHEEVPEAAPGNNVGFNVKGLSVKDIKRGFVASDSKNDPATDTESFVSHTIVMNHPGEIKAGYTPVIDCHTAHIACKFEELLTKADKRSGKMTEENPKFLKAGDAGLIRLSPSKPLCVETFATYAPLGRFAVRDMRQTVAVGVIQEIKKKATEDKKGKKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha 1, EF-1-alpha-1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_BARBK
Sequence: MQKHTPSVSCSPFPSSHKFYQQSLLFPNVRVPLRKILLTDGSGESPFNVYDTSGPYTDENVIIDITKGLPAIRIPWLSERADTESYPARLVKPEDNGFTHGKDLTPVFEKKRPILRSKNGKSITQMTYARAGIITAEMEYVAIRENEGLIEKNKQHTTSSKAFDASIPEVYTAEFVRNEIACGRAIIPQNINHPECEPMIIGRNFRVKINANIGNSAVTSSMAEEVEKMVWAIRWGADTVMDLSTGRNIHNIREWIIRNSPVPIGTVPIYQALEKVHGIAENLTWDIFRDTLIEQAEQGVDYFTIHAGLKLAFIPLTIDRTTGIVSRGGSIIAKWCLHHHKENFLYEHFDEICDIAHTYDVSLSLGDGLRPGSIADANDEAQFAELKTLGELTQIAWEKNVQTMIEGPGHVPMHKIKENMDQQLALCNEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPDKNDVKTGVITYKIAAHAADLAKGLPRAQLRDNTLSRARFDFRWHDQFNLSLDPDTARAFHDETMPKEAHKLAHFCSMCGPKFCSMRISHDIRDAVAIKKTRDEGMAAMAEKYQQNGDLYMKVMPSIKETVDD
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.