PharMolix/UniProtQA huggingface dataset:
Protein: YIDD_ECODH
Sequence: MAPPLSPGSRVLIALIRVYQRLISPLLGPHCRFTPTCSSYGIEALRRFGVIKGSWLTVKRVLKCHPLHPGGDDPVPPGPFDTREH
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GAP6_CANAL
Sequence: MPKEASSPECYTTSTSSNEISEKPGMWRNFKDSFKPPVPIDDIENGSISSTQLKGGQNVPLQQSLKKRQLQMIALGGCVGSGLLVASGAALRNGPASLLIAWFIVSTFLYCTMQCLAELSSTFPVSGSFAVYSIKFIDPSWGTAMGYNYALFWVVVMPLELVASSMTIKFWPSNINTSVWVAVFYVLIIGTNLFGGTRAFGETEFVASVIKLLGIVGFNILAIVLICGGGDQGYIGGKNWHPPFTTGVKGVISVLLTATYSLAGTELVGLTSAEAAGDARKVLPKAIKQVLWRILIFYLLTLTLVGFLVPASDPQLIGGGSGASASPFVIAIREGGIKGLPSVFNVVVLVALLAIANSAVYGFSRTILALAEQGVAPSIFKYVDRQGRPLAGIATSAIVGLLSFVSASKQQEQVFDWLVALSGLSTFFTWGSINAAHIRFRIAMKVQGRSLDELPYKANTGVLGAYYGLIMNVAVLALQFWLAVWPIGGKPDATYFFKQYLAAVLVLAVYVIHKVATRNWKFMVDYKDMDLDSGRSDIDIDILKQELEEEREAYKRQPWYYKFYQFWC
What is the function of this protein?
Amino-acid permease with rather broad substrate specificity (PubMed:21764911).  Transports many amino acids including proline, methionine, leucine, valine, isoleucine, phenylalanine, tryptophan, threonine and tyrosine, but not basic ones (arginine) and citrulline (PubMed:21764911, PubMed:28028545).  Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA (PubMed:21764911).
What are the official names of this protein?
Amino-acid permease GAP6.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: F16PA_CAMJE
Sequence: MQEVISYIQKAVLEISNALKFPDTSYSQNQNFTGDTQLKFDVLSDEIITKTLSQCSSIKAIISEEKDEILTLNERANFIVAYDPLDGSSLMDVNFAIGSIFAIYEEKASAKNLRAALYSMYGARLELVICKDQPKLYRLNANNEFIFIKDLRMNEKGKINATGGTQKFWEEKHAKFIKSLFDEGYRLRYSGAMVSDINQILLKGGGIFSYPATQDAPNGKLRAFFEVFPLAFIIEKAGGKTTNGKNRSLLELEFDKIHATTPCFFGSEYEISKLLKAYNE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_PROMP
Sequence: MGNKINPTGFRLGITQEHRSKWFATSKTYPTLLQEDDKIRTFIQKKYSSAGISDVLIARKADQLELELKTARPGVIVGRQGSGIEELRSGIQKTIGDRTRQVRINVVEVERVDADAYLLAEYIAQQLEKRVAFRRTIRMALQRAQRAGVLGLKVQVGGRLNGAEIARTEWTREGRVPLHTLRAEVDYALREANTTYGVLGIKVWVFKGEVLPKEEQTIPVGAIPRRKGSRKPQQFEDRSNENS
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: ADDA_MOUSE
Sequence: MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPDLRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTASVPNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTNLGVNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGDVAYHDYHGILVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGGPDNLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQIGEQEFEALMRMLDNLGYRTGYPYRYPALRERSKKYSDVEVPASVTGHSFASDGDSGTCSPLRHSFQKQQREKTRWLHSGRGDDASEEGQNGSSPKSKTKWTKEDGHRTSTSAVPNLFVPLNTNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVMMDRSLVQGELVTASKAIIEKEYQPHVIVSTTGPNPFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSDGSPGKSPSKKKKKFRTPSFLKKSKKKSDS
What is the function of this protein?
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network.  Binds to calmodulin.
What are the official names of this protein?
Alpha-adducin, Erythrocyte adducin subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. Adducin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PTVO1_RAT
Sequence: MVRPRRAPHRSGAGGPLGGRGRPPRPLVVRAVRSRSWPAGPRGPQPPRIRARSAPPMEGARVFGALGPIGPSSPGLTLGGLAVNEHRLSNKLLAWSGVLEWQEKRRPFSDSAAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNAIRQVITTRKQAVGPGGVHSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTDQWPRRLFMQLIPQQLLTTLVPLFRNSRLVQFHFTKDMETLKSLCRIMDNGFAGCVHFSYKASCEVRVLMLLYSSEKKIFIGLIPHDQSNFVNGIRRVIANQQQVLQRSLEQEQQQRGMGG
What is the function of this protein?
May activate transcription.  Required for nuclear translocation of FLOT1.  Promotes cell proliferation.
What are the official names of this protein?
Prostate tumor-overexpressed gene 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane. Cytoplasm, perinuclear region. Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts.
Protein: SELO_ALISL
Sequence: MSIWNSLSLSTRYSELPPLLFTHVPPQPLNNVHWIMWNEKLAKRFNLPLDPAADAELLSGFSGEVVPPQFSPLAMKYAGHQFGSYNPDLGDGRGLLLAEIKDKAGASFDIHLKGAGRTPYSRSGDGRAVLRSTIREYLCSEAMFGLGIPTTRALGMMGSDTPVYREGYETGALLLRVAETHVRFGHFEHLFYSNLLAEHKLLADKVIEWHFPDCLDNENPYAVMFNEIVDRTAKMIAHWQAVGFAHGVMNTDNMSIIGQTFDYGPFGFLDDYEPGYICNHSDYQGRYAFNQQPRIGLWNLSALAHALSPLIDKADLDQALEQYEVQLHGYFSQLMRQKLGLITKQDGDSRLFESMFELLSQNSVDYTRFLRELSNVDTHNEQAIIDLFIDRDAAKLWVSLYITRCEKEHETVASRCKKMREVNPKYILRNYLAQQAIDKAQEGDYSELEALSLLLRSPFDEHIEFEHYANLPPSWGKKMEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: LPXD_BURCH
Sequence: MALTLEELVKRFGGEIAGDAQCKVGGLAPLDQAGPQQLAFLANPKYLSQVESTRAGAVLIAPKDLEKLGAAAQGRTAGPRNFIVTPNPYAYFARVAQMFIDLATPPRAAGVHPSATIDPAAKVAATAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHFYPNASVYHGCKVGPRAIVHAGAVIGSDGFGFAPDFVGDGDARTGSWVKIPQVGGVTIGPDVEIGANTTIDRGAMADTVIEECVKIDNQVQIGHNCRIGAYTVIAGSAGIAGSTTIGRHCMIGGAAGIAGHVTLGDYVIITAKSGVSKSLPKAGIYTSAFPAVDHGEWNKSAALVRNLDKLRERIKALEAALAAQGGTDA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: YGFZ_SERP5
Sequence: MAYKIPFPPRQPSASSHLPLTLISLEDWALVTLNGPDRVKYLQGQVTADIEALPADSHVLCGHCDAKGKMWSNLRLFHRGEGFAYLERRSVLDSQLAEIKKYAVFSKLTIAADSEAVLLGVAGFQARAALAGVFNSLPDAEHQVVQDGETTLLHFSLPAERFLLVTTAAVAEQLVDKLHEQAELNDSQQWLTLDIEAGYPVIDAANSGQFIPQATNLQALDGISFSKGCYTGQEMVARAKFRGANKRALYWLEGKAGRVPQAAEDVELQLGENWRRTGTVLSAARLADGTLWVQVVLNNDLDADSKLRVRDDATSQLAIKPLPYSLAEEK
What is the function of this protein?
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs.  It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
What are the official names of this protein?
tRNA-modifying protein YgfZ.
What is the protein family that this protein belongs to?
Belongs to the tRNA-modifying YgfZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHPN2_CANLF
Sequence: MTDALLPAAPQPLEKESDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNHKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQSTEEAFTVPLIPLGLKETKDIDFSVVLKDFILEHYSEDSYLYEDEIADLMDLRQACRTPSRDEAGVELLMSYFIQLGFVESRFFPPTRQMGILFTWYDSLTGVPVSQQNLLLEKASILFNIGALYTQIGTRCNRRTQAGLDGAVDAFQRAAGVLHHLKETFTHTPSYDMSPAMLSVLVKMMLAQAQENVFEKICLPGIRNEFFVLVKVAQEAAKVGEVYRQLHTAMSQAPVKENIPYSWASLVCVKAHHYAALAHYFAATLLIDHQLKPGADEDHQEKCLSQLYDHMPEGLTPLATLKSGHQRRQLGKSHLRRAVAHHEESVREASLCKKLRNIEVLQDVLSVAHERSRLKYAQHQDDDDLLNLIDAPDIISKTEQEVEIILPQFSKVTATDFFQKLGPLSVFSANKRWTPPRSIHFTAEEGDLGFTLRGNSPVQVHFLDPHCSAALAGAKEGDYIVSIQDVDCKWLTVSEVMKLLKACGRDGVEMKVVSLLDFTSSMHNKCATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTDKNRVKSASTLCLPSVGVARPQVKKKLPSPFSLLNSDSSLY
What is the function of this protein?
Binds specifically to GTP-Rho.  May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity).
What are the official names of this protein?
Rhophilin-2, 76 kDa RhoB effector protein, GTP-Rho-binding protein 2, p76RBE.
What is the protein family that this protein belongs to?
Belongs to the RHPN family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.
Protein: TM213_HUMAN
Sequence: MQRLPAATRATLILSLAFASLHSACSAEASSSNSSSLTAHHPDPGTLEQCLNVDFCPQAARCCRTGVDEYGWIAAAVGWSLWFLTLILLCVDKLMKLTPDEPKDLQA
What are the official names of this protein?
Transmembrane protein 213.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RM20_MOUSE
Sequence: MVFLTTRLWLRNRLTDRYWRVQEVLKHAQHFRGRKNRCYRLAVRAVTRAFVKCTKARRLKKRNLRTLWINRITAASQEHGLKYPAFIVNLIKCQVELNRKVLVDLAIYEPKTFKSLAALAKRRQQEGFAAALGDGKEPEGIFSRVVQYH
What are the official names of this protein?
39S ribosomal protein L20, mitochondrial, L20mt, MRP-L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RS18_MYCLE
Sequence: MAKSTKRRPAPEKPAKARKCVFCAKKNQQIDYKDTTLLRTYISERGKIRARRVTGNCVQHQRDIAIAVKNAREVALLPFTSSAR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: NADE_SHEB9
Sequence: MKAQILREMKVLTAIEPEFEVQRRVAFIKTKLKEARSKALVLGISGGVDSSTAGRLCQLAVDSLNHENSQGGYQFIAVRLPYQIQKDEHEAQLACQFIQPSKLVTVNVHQGVDGVHSATVAALAEAGLPLPDVAKVDFVKGNVKARMRMIAQYELAGLVGGLVVGTDHSAENITGFYTKWGDGACDLAPLFGLNKRQVRQLAAYLGAPESLVHKAPTADLEDNKPLLEDEVALGLTYAQIDDFLEGKDVGKAVEDKLIGIYKATQHKRQPIPTIYD
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: DAPB_SCLS1
Sequence: MAGHTEENAQLLSTEQESVSRHSSDSAASTASTTSLVFDRIGERVAANRSEKSMMVTPKFPPRGEMAYADDEHTQIHLDEEEEKDYDLEDSAFLTNGATNKSVDKKLRKLIWIVGGVFIGAWVLALFIFLGKQAYKHSSEIPHDPQATSSRGNGKKVTMDQVMGGQWRATKHSISWIAGANGEDGLLLEQGSAGKDYLIVEDVRTQNPETVGTLDRMTLMKDGSFTVAGRSLYPSKVYPSKDLKKVLVATDVQSNWRHSFYAKYWIFDVESQTAEPLDPVDLDGRVQLASWSPKSDAIVFTRDNNMYLRKLSSPTVIQITTDGGPEFFYGVPDWVYEEEVFAGASATWWDDSGKYIAFLRTNESEVPEYPIQYFVSRPSGKEPLPGEENYPEVREIKYPKAGAPNPTVDLLFYDIFKAEVFEVTIAGGFEPKNLLITEVVWAGSTGKALIRETNRESDILRVVLVDVVAREGKTVRYTDINKLDGGWFEVSEDTRYIPADPANGRPHDGYIDTIIHENYDHLGYFTPMDNPEPILLTSGNWEVVQAPSAVDLKNNLVYFVSTKESPITRQVYSVKLDGTDMKAITDTSNEGYYGASFSKGAGYVLLNYNGPGIPWQKVISTPSNGNQYTHTIEENKGLAEMAKKHDLPILIYQTVTIDGFELQVVERRPPHFNPKKKYPVLFYLYGGPGSQTVSKSFNVDFESYIASNLGYIVVTVDGRGTGFIGRKARTIIRGNIGHYEARDQIETAKIWASKKYVDASRMAIWGWSYGGFMTLKTLEEDAGETFSYGMAVAPVTDWRFYDSIYTERYMHTPQHNPGGYDNTSISNVEALSKNVRFLVMHGVADDNVHMQNTLTLLDKLDLAGVENYDVHVFPDSDHSIYFHNANRIVYDKLNNWLINAFNGEWLRTANAVPLQIDAAKV
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: FEN1_ASPNC
Sequence: MGIKQLYQVISENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSDTGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFARKSEATEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFETPILLRHLTFSEQRKEPIQEIHLNRALEGLGMDRKQFIDLCILLGCDYLEPIPKVGPNTALKLIRDHGSLEKVLEFMENDPKKKFVVPEDWPYEDARELFLNPDVRDANDPECDFKWEAPDVPGLVDFLVKDKGFNEDRVKNGAARLQKNLKSAQQSRLEGFFKPVARTDEEKASLKRKHDEKIQEQKKKKKEEAKAKKEAKSRPRGAG
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: LLDD_ESCF3
Sequence: MIISAASDYRAAAQRILPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNEKLSMPVALAPVGLCGMYARRGEVQAAGAADAHGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKAGVANLLNLIEKEMKVAMTLTGAKSISEISQDSLVQELDKALPAALAPLAKGNAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BIBH_CAEEL
Sequence: MKVFSLILIAFVANAYCDEGASTEKEEKMGTIIGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFSGDQGERLIGDAAKNQLTINPENTIFDAKRLIGRFYNEKTVQQDIKHWPFKIVDKSNKPNVEVKVGSETKQFTPEEVSAMVLTKMKQIAESYLGHEVKNAVVTVPAYFNDAQKQATKDAGSIAGLNVVRIINEPTAAAIAYGLDKKDGERNILVFDLGGGTFDVSLLTIDSGVFEVLATNGDTHLGGEDFDQRVMEYFIKLYKKKSGKDLRKDNRAVQKLRREVEKAKRALSTQHQTKIEIESLFDGEDFSETLTRAKFEELNMDLFRATLKPVQKVLEDADMKKTDVHEIVLVGGSTRIPKVQQLIKDYFNGKEPSRGINPDEAVAYGAAVQAGVIGGVENTGDVVLLDVNPLTLGIETVGGVMTKLIGRNTVIPTKKSQVFSTAADSQSAVSIVIYEGERPMVMDNHKLGNFDVTGIPPAPRGVPQIEVTFEIDVNGILHVSAEDKGTGNKNKLTITNDHNRLSPEDIERMINDADKFAADDQAQKEKVESRNELEAYAYQMKTQIADKEKLGGKLTDEDKVSIESAVERAIEWLGSNQDASTEENKEQKKELESVVQPIVSKLYSAGGQGEQASEEPSEDHDEL
What is the function of this protein?
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity).  Required for ER dynamics during the first embryonic cell divisions (PubMed:15716356).  Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion (PubMed:15716356).
What are the official names of this protein?
Endoplasmic reticulum chaperone BiP homolog, Heat shock 70 kDa protein D.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RS2_MESM1
Sequence: MNINDMNDAPEVSSSESQKNEIVSKQKLLEAGTYFGHKASLWNPKMKPFIHSKKMGTHIIDIAQTRKALEYAYKLIEKYAQKGASFIFVGTKKQAKDVVKAQALRTNSIYVSERWLGGTLTNSRTIMNQVRTLSDLEKLEESGYEGYTKKEGVEFSKKLAKLQRNLTGIRNMKHLPQVMIVADVNTDKIAIKEAQRKNIKIIGILDTNSDPSLVNFGIPANDDSVKSLNLIITILADAIVAAKNGKQLFAYQGDEAIVFPATSENVGKDGEERKPRKPYVKRRPDGDFQPRHNNNESETK
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: FB43_ARATH
Sequence: MEQQKQKKRKVVSKSKRTQSKSASSLPLDLTSEILLRLPEKSIARFRCVSKLWLSITTDPYFINLFETRSPRPSLLVCFIENDKLFVSSIPQHLHSLQNSKRSYSSSQLFIVIIWNYQKDVGLICFKTSKMPIVWNPSKRQLITLPIPRLSWNNIIVFLGYDPVEGKHKVMCLPFRRSSDVCQVLTLGPAQEFSWITVKTYHKHCSDYQSSGRCIKGVVYYIAQVYHTHAWVLMCFDVRSEKFDMIKLHADIYREILITYEGRIACVEKRTTKDDYIALCILEDAKKDKWSSKDILAPFGHFDERLRTFFQLKGCTHDGEFIFVSSTFRKMDYILFFDPVKKTFRRFELKEIADDQARVNNGDPYGPIFAFCAFLDHVESQMSLQ
What are the official names of this protein?
Putative F-box protein At1g47765.
Protein: RPOC1_GLOC7
Sequence: MKQPTEQRFDYVKIGLASPDRIRQWGERTLPNGILVGEVTKPETINYRTLKPEMDGLFCERIFGPSKDWECWCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGFIKLAAPVTHVWYLKGIPSYLSILLDMPLRDVEQIVYFNAYVVLDPGNSGNLQYKQLLTEDQWLEIEEQIYAEDSELYGIEVGIGAEAIERLLQELNLDEEAEKLREEIIESKGQKRAKLIKRLRVIDNFIATGSQPDWMVLTVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLSRLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKIFQCGLPREMAIELFQPFVIHRLIKLGLVNNIKAAKKMIQRGDPQVWNVLEEVITGHPVLLNRAPTLHRLGIQAFEPILVEGRAIQLHPLVCPAFNADFDGDQMAVHVPLSLESQSEARLLMLACHNILSPATGRPIVAPSQDMVLGCYYLTSENPKAQKGAESYYSDLEDALMAYEQGLVDLHAYVWVRCDLEVVTEQPDDKPIKTETSEDGTVTKYYRHRKVRETADGKLICQFIHTTVGRIIYNKTVQDTLVA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: HIS2_NITEC
Sequence: MTSSSTILQRLTQTIEARKSADPAHSYIAKLLSSNEDKVLKKIAEEAAETIMACKDNDREQIIYETADLWFHCLIMLARHDISPEAILSELERREGVSGIEEKLSRSQNQPEPTKAE
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_ACIF2
Sequence: MKISYLDFEQSVAELDAKVEELHALNQPGIADDISRLEVKARKELQRIYSKLGAWQTVQVARHPQRPYTMDYVQALFTEVQVLAGDRAFADDQAIIGGLARFNGQPIVWMGHQKGRDTKEKIQRNFGMPRPEGYRKALRLLRLAERFALPVFTFIDTPGAYPGIGAEERGQSEAIARNLAVMSDLAVPIICTVIGEGGSGGALAIGVGDRMLMLEYGVYSVISPEGCASILWKNAAMAAEAAETLGITARRLQGMGLVDEVLAEPLGGAHRDPEAVFALARERFAHHLQELQAMDTSKLLTTRYERLMHYGVVGAA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_SALPK
Sequence: MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVGAVNGPIAQAILGKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKGKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SPO24_YEAST
Sequence: MVAFLELTSDVSQPFVIPSLSPVSQPSSRKNSDANVDDLNLAIANAALLDASASSRSHSRKNSLSLL
What is the function of this protein?
Required for efficient sporulation.
What are the official names of this protein?
Sporulation protein 24.
What are the subcellular locations of this protein?
Prospore membrane; Peripheral membrane protein.
Protein: IGHG1_HUMAN
Sequence: ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
What is the function of this protein?
Constant region of immunoglobulin heavy chains.  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).  Mediates IgG effector functions on monocytes triggering ADCC of virus-infected cells.
What are the official names of this protein?
Immunoglobulin heavy constant gamma 1, Ig gamma-1 chain C region, Ig gamma-1 chain C region EU, Ig gamma-1 chain C region KOL, Ig gamma-1 chain C region NIE.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: SSB_SHIFL
Sequence: MASRGVNKVILVGNLGQDPEVRYMPNGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVASEYLRKGSQVYIEGQLRTRKWTDQSGQDRYTTEVVVNVGGTMQMLGGRQGGGAPAGGNIGGGQPQGGWGQPQQPQGGNQFSGGAQSRPQQSAPAAPSNEPPMDFDDDIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.