PharMolix/UniProtQA huggingface dataset:
Protein: THIG2_SYNC1
Sequence: MDELVIAGRSFSSRLMVGTGKFASNSLMADALAASGSQIVTVALRRVDIDRPEDDLLAHIDRDKYLLLPNTSGARDAEEAVRLARLARAAGCEPWVKLEVTPDPYYLLPDPIETLKAAEILVKEGFVVLPYINADPVLAKHLQEAGTATVMPLGAPIGTNKGVRTRDNIAIIIEQAIVPVVVDAGLGAPSHVAEAMEMGADAVLVNTALAVTPDPAGMAHAFRLGVEAGRRAFLAGLPAQQQKAEASSPLTGFLRDEQ
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase 2.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_SHEB5
Sequence: MSLSTEVKAKILADFGRCENDTGSTEVQVALLTAQINHLQAHFKEHIHDHHSRRGLLRMVSSRRKLTAYLKRTDVARYTALIQKLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: Y2161_VIBCM
Sequence: MKKRYWMAPLLIAAAGLAAFWSIFTIPTQPELVTIGRNQQGEPLLCYQHPQSEVLDLDGELNLLVWNIYKQNRANWSTQLTELSRDQQLLLLQEANMTPAFKEWIHQLGWDGTQARAFEAFGETAGVINLAKVMPTMACAYTQLEPWLRLPKSAIYARYRLSDGQELVVVNLHAVNFTYGTQEYQQQLIALLDELRDFTGPVIVAGDFNSWSEARMALLSTQLASVGLQEVRFSPDNRTTFINGLPLDHVFYRGLQLEKAEAPISDASDHNPLLVRFRLLN
What are the official names of this protein?
UPF0294 protein VCM66_2161.
What is the protein family that this protein belongs to?
Belongs to the UPF0294 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_TRIL1
Sequence: MILGIGIDTVEISRFQRFLDEDNQALLNRLFAPAEQEYCRPRKQAASCLAARFAAKEAFVKALGTGLRDGICWTEIAVGNDQLGKPFLKLSGRALQLFSEQGAASAHLSLSHDGGHAVAQVILEAP
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENDOA_BACSU
Sequence: MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Specific for 5'-UACAU-3' sequences, cleaving after the first U (PubMed:21763692).  Yields cleavage products with 3' phosphate and 5' hydroxyl groups (PubMed:15882409).  Cannot digest substrate with a UUdUACAUAA cleavage site (PubMed:24120662).  Overexpression is toxic for cell growth (shown in E. coli), probably by inhibiting protein synthesis through the cleavage of single-stranded RNA.  The toxicity is reversed by the antitoxin EndoAI.  Toxin activity cannot be inhibited by MazE from E. coli.  The EndoA-EndoAI complex does not seem to bind its own promoter (PubMed:24120662).
What are the official names of this protein?
Endoribonuclease EndoA, Toxin EndoA, mRNA interferase EndoA, mRNA interferase MazF-bs, MazF-bs.
What is the protein family that this protein belongs to?
Belongs to the PemK/MazF family.
Protein: LUXS_VIBCM
Sequence: MPLLDSFTVDHTRMNAPAVRVAKTMQTPKGDTITVFDLRFTMPNKDILSERGIHTLEHLYAGFMRNHLNGSQVEIIDISPMGCRTGFYMSLIGAPTEQQVAQAWLAAMQDVLKVESQEQIPELNEYQCGTAAMHSLEEAKAIAKNVIAAGISVNRNDELALPESMLNELKVH
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: PACC1_PONAB
Sequence: MIRQERSTSYQELSEELDQVVENSELADEQDKETVKVQGPGVLPGLDSESASSSIRFSKACLKNVFPVLLIFIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEVDRYDAPGIALYPGQAQLLSCKHHYEVIPPLTSPGQPGDMNCTTQRINYTDPFSNQTVKSALIVQGPREVKKRELVFLQFRLNKSSEDFSAIDYLLFSSFQEFLQSPNRVGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAEKSAQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSIKWMIKIRKRYLKRRGQATSHIS
What is the function of this protein?
Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH.  Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling.
What are the official names of this protein?
Proton-activated chloride channel, PAC, Transmembrane protein 206.
What is the protein family that this protein belongs to?
Belongs to the proton-activated chloride channel family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HRPA_PECCC
Sequence: MALGLSQVASQAASQTLDTAMAGSLTRAAGAQAQKIALDTENSILDGQMDSASKSLNSGQKAAKAIQF
What is the function of this protein?
Major structure protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity.  The hrp pilus functions as a conduit for protein delivery into the host cell (By similarity).
What are the official names of this protein?
Hrp pili protein HrpA, TTSS pilin HrpA.
What is the protein family that this protein belongs to?
Belongs to the HrpA type 2 family.
What are the subcellular locations of this protein?
Secreted. Fimbrium. Note=Extracellular and secreted via type III secretion system.
Protein: RL7_DESAL
Sequence: MADITKEDVLEFIANMTVLELSELIKDIEEKFGVSAAAPVAAVAMAGPAAADAEEEKTEFDVILLSAGDKKIQVIKEVRAITGLGLKEAKALVEEAPKAVKEGIAKEDAEKVKEQLEGAGAQVDIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: FPG_WOLPM
Sequence: MPELPEVEVISNFLLDKIKNKQISNVIVNNWNLRAPITKNIDDMLKGKVIRNIKRRGKYTIWNTDGSVAVIIHLGMSGKLIYADHDQMRNKHDHVVFLFSDNTSIIFNDPRRFGLVIVLNKEQETDFFSDFGIEPLTDEFSGDYLQELLKNKKVNIKSALMDNKSIVGVGNIYASESLFRARISPLRSAKNLTYRECEKLAAEIKNTLSDAIAAGGSTLKDYAQPSGSAGYFQNNFYVYGKVQKPCKICNNIITLIRQNGRSTYFCNACQN
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: NADK_CAMJR
Sequence: MQNKIDYKNIKKIGLVTRPNVSLDKEILKLQSILSIYKVELVLLKESSEILDLPKYGLDDLFKISDFVISLGGDGTLISLCRKACEYDKAVLGIHAGHLGFLTDFKVDEAENFFQAFFQGEFRIEKPYLLSVFLEDKQGKILEKLAFNDVVISKNNQASMAHIEVFRKEKKFNEYFGDGLIVATPAGSTAYNLSANGPIVYTLAQAFILTPVCSHSLTQRPIVLPKGFEIEIMAKDCILCIDGQENYKMNDFKSIKVGLSDKNVALIHPKNRDYFQILKEKLHWGN
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG147_VAR67
Sequence: MITLFLILCYFILIFNIIVPAISEKMRRERAAYVNYKRLNKNFICVDDRLFSYNFTTSGIKAKVAVDNKNVPIPCSEINEVNNNKDVDTLYCDKDRDDIPGFTRSCYRAYSDLFFTT
What is the function of this protein?
Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry.  Also plays a role in cell-cell fusion (syncytium formation).
What are the official names of this protein?
Virion membrane protein OPG147.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG147 family.
Protein: MRAY_THISH
Sequence: MLLSLFEFLSEYYRGFNVFQYLTLRAILGVLTALIIAFLVGPAMIRRLSLYKIGQQVRTDGPQTHLTKAGTPTMGGALILVAVAVSTLLWSDLSNRFVWVVLMVTLLFGLIGGIDDYRKLRYGNSKGLSARTKFFWQSVVGFATAILLYYTAQAPVETTFFVPLFKDVAIQLGPWFILLTWFVIVGASNAVNLTDGLDGLAIMPTVLVAGAFGVFAYLSGHAVFANYLGIPYVPGVGDLVVFTGALVGAGLGFLWFNAYPAQVFMGDVGALALGAALGVLAVVTRQEIVLVIMGGVFVVETLSVIMQVVSYKLTGRRIFRMAPLHHHFELKGWPEPRVIVRFWIITVILVLVGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BDNF_MACMU
Sequence: RHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTL
What is the function of this protein?
Important signaling molecule that activates signaling cascades downstream of NTRK2.  Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2.  Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD).  Binding to NGFR and SORCS2 promotes neuronal apoptosis.  Promotes neuronal growth cone collapse.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted. SUBCELLULAR LOCATION: [BDNF precursor form]: Secreted. Note=A proportion of BDNF is secreted as immature precursor (proBDNF).
Protein: PUFQ_CERSP
Sequence: MSDHAVNTPVHAARAHGHRAPRAEFYVYFAVILLGGFPVAFVSWIVSTIRHRRLPKRGPFASAWFDAKAITPLIFRA
What is the function of this protein?
Required for bacteriochlorophyll biosynthesis.  Directly involved in the assembly of both the B875 and B800-850 pigment-protein complexes.
What are the official names of this protein?
Protein PufQ.
What is the protein family that this protein belongs to?
Belongs to the PufQ family.
Protein: HSPQ_ERWT9
Sequence: MIASKFGLGQQVRHQLYGFLGVIVDVDPEYSLADTEIDDAATSETLRGAPWYHVVMEDDDGQTVQTYLAEAQLSWEIPGEHPEQPSLDELAASIRQQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_BARBK
Sequence: MLQPKRTKFRKQFKGRIHGASKGGTDLNFGAYGLKVVEPERITARQIEAARRAITRYMKRSGRVWIRVFPDLPVTSKPTEVRMGKGKGSVDYWAARVAPGRIMFELDGVPEDVAREALRLGAAKLPIKTRFIQRIVE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RL21_AERPE
Sequence: MVKAPRGYRNRTRRLLRKPVREKGSIPRLSTYLREYRVGDKVAIIINPSFPDWGMPHRRFHGLTGTVVGKRGEAYEVEVYLGRKRKTLFVPPVHLKPLSTAAERRGS
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: ADDA_LACAC
Sequence: MPQFTKEQQQAIDDRGHDILVSASAGSGKTTVLVERVLKEIISGTQVSELLVVTFTKAAAEEMKTRIKTALTKELAKPGVNRKYLREQLNQVDTANISTIDAFCLEVIRRFYYSVNLNPSFKILTDETQAALIKERALREIEAESLTDENSGIRYFYDNFAGDRDANSPRDLLLDLYNFAMAKPEYRSWLKNLAKIYEVNNNIVKSKLWQNQIKSYLLNTFVSLQKKIEEYLNNPTIETKELAKVKEDFSLFTQNLDKFIDAIKNDEDYDQQRNLLRLCKFEVKYRKSAKWDEDIQEFYAETQKLKSEAKSQIFDIFTAFYATDEKEQTRIMQESQKIVSAISKAELALIDRFNELKRNENFLDYSDMEQLAYQILSADTSNSQMAREFYQNKFKEILIDEYQDINALQERIIQQVKNTDKNTLFMVGDVKQSIYGFRQAEPSLFLKKYHGFASEENKHEKRILLSDNFRSTEPVTKTVNQLFKSILSSDFGGIDYSKEGQLIFGAKYYPDALPKASEIIVHKKQKDIDNDNNGIDFSEVEMVLARIKQLKKEHFQVLDSTTGEVRALKYSDIAILTRSHGDNLEIMQEFAKRDIPLFITDAENYFQTFELTVIMNYLKIIDNPDQDIPLVTVLRSPLFNFSEKDLAKIRINSKNSGFYSAVASYVGIGDELSDRCKNFLNKLDELRKFATTHRISELIWSIYAQTNLLEIMTGLPNGEQRRINLEALYERASSYESAGFKGLYQFINFINRMRRSQKDLAQPLLSKEAGNAVRLMTIHGSKGLEFPVVFYLGMQHQYQLRDLKGNYVINPDSLGITLRQEHYRVDSLVKAIGNVTKKRQLLEEEARVLYVALTRAKQKLILVGDIANLDKKVQDWSIELDQSGQLSLADKLSVTNPLGFMGPALAFDKHIVINMNDISNALDQSQSVLYVEYKDSDNFEFKKDEDKVVGDSKNNNYTMDKLISTTKKLYQFDYPFKDASETTAYQAVSEIKKAFNDPIETELENSRLLSSTNRYLQPIDTKPNFLYQTKFTGAEIGTATHLILQYYDYTGDGSEKQLDYEIEELIKQKKLNPDIVPSLHKDQIQWFVHSSFAKSFWKNPENLQREVDFSSLISAKNLFKDFSDANAKILVHGTIDGYFVSNDGIILFDYKTDHVNKSYLDKSINLIKEKYTGQLRLYEQAINEFGEEKVIGKYLILLDAKQVVEVK
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: DLGD_SHIFL
Sequence: MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTTAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL
What is the function of this protein?
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
What are the official names of this protein?
2,3-diketo-L-gulonate reductase, 2,3-DKG reductase, 3-dehydro-L-gulonate 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANXD4_ARATH
Sequence: MALPLELESLTEAISAGMGMGVDENALISTLGKSQKEHRKLFRKASKSFFVEDEERAFEKCHDHFVRHLKLEFSRFNTAVVMWAMHPWERDARLVKKALKKGEEAYNLIVEVSCTRSAEDLLGARKAYHSLFDQSMEEDIASHVHGPQRKLLVGLVSAYRYEGNKVKDDSAKSDAKILAEAVASSGEEAVEKDEVVRILTTRSKLHLQHLYKHFNEIKGSDLLGGVSKSSLLNEALICLLKPALYFSKILDASLNKDADKTTKKWLTRVFVTRADHSDEMNEIKEEYNNLYGETLAQRIQEKIKGNYRDFLLTLLSKSD
What is the function of this protein?
May be involved in osmotic stress and abscisic acid signaling in a calcium-dependent manner.
What are the official names of this protein?
Annexin D4, AnnAt4.
What is the protein family that this protein belongs to?
Belongs to the annexin (TC 1.A.31.1) family.
Protein: ATPF_GEOMG
Sequence: MANACKKKRLLKSVMMPAAVCAAVIGLSALGFAAEGGEGAHHVDTGKQMKDFMWRVIDFAALLGVIIWALKKANAKGALADRTANIEKALREAEEARAAAEKKFAEYSGKLEKANLEIDDIYAAIRKEAELEKERIIAEAKLTADKIREQAAATASQEVLKAKAELRGEAARLAVQMAEQSLRENIKKDDQDRLVNDYLTKVENLH
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: IHFA_SHEFN
Sequence: MALTKAEMAEHLFETLGINKRVAKEMVESFFEEIREALESGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPISARRVVTFRPGQKLKSRVEAANSGKK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: Y4DX_SINFN
Sequence: MAAHLCRGRGAVGRREMLRGSGKKPIQRLAKAPAATASSKTSEWRATTAYGFLPAGGDVRPHSPRYESQGVLSDPADLGERFAARDELAEEGKEERFAEPPDRRLGLDVKGAANDIGVEFIEDDPEAQVCIEAGPPLLDGRNFSRAASLLGLLGGDREKQNQVVIRSGKPHADGDWPILPPLYLSFSGLPRA
What are the official names of this protein?
Uncharacterized protein y4dX.
Protein: RL21_THEPX
Sequence: MYAIIETGGKQYMVREGDVLVVEKLNYPEGEVISFDKILAVSKEDGNVEFGKPYLENVKVNAKIIEHGKGPKIRVFKYKPKKNYRRRQGHRQPYTKVQIEKIVQ
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: ATPA_MYCSS
Sequence: MAELTISAADIQGAIEDYVANFATDTEREEIGTVIDAGDGIAHVEGLPSVMTQELLEFPGGVLGVALNLDEHSIGAVILGDFEKIEEGQQVKRTGEVLSVPVGDGYLGRVVNPLGQPIDGRGEIETTDRRALELQAPSVVQRQGVSEPLQTGIKAIDSQTPIGRGQRQLIIGDRKTGKTAVCVDTILNQRQNWETGDPNQQVRCVYVAIGQKGTTIASVRRTLEEGGAMDYTTIVAAPASDSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLTKHAEAYRAISLLLRRPPGREAFPGDVFYLHSRLLERCAKLSDELGGGSMTGLPLIETKANDISAYIPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELESFAAFASDLDATSKAQLDRGARLVELLKQPQNSPMPVEEQVVAIFLGTRGHLDTVPVEDVQRFEQELLEHVRSSKEEIFTEIRESKKLSDELEKTLTDVVNEFKKGFETTSGESVVPDENVEAMSEDDVEKESVKVRKPAPKKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PDXB_ECOSM
Sequence: MKILVDENMPYARDLFSRLGEVTAVPGRPIPVAQLADADALMVRSVTKVNESLLAGKPIKFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSSLLMLAERDGFSLHERTVGIVGVGNVGRRLQARLEALGIKTLLCDPPRADRGDEGDFRSLDELVQHADILTFHTPLFKDGPYKTLHLADEKLIRSLKPGAILINACRGAVVDNTALLTCLNEGQKLSVVLDVWEGEPELNVELLKKVDIGTPHIAGYTLEGKARGTTQVFEAYSKFIGHEQHVALDTLLPAPEFGRITLHGPLDQPTLKRLVHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVICDDASAASLLCKLGFNAVHHPAR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_LISMF
Sequence: MASLIDIKQRITSTRKTSQITKAMQMVSAAKLGRAESNARSYEPYVSKIKDVVTHVASTGNSSDHPMLVSRPVHRTGYIVLTSDTGLAGSYNSSVIKEVFQEINKKHTSSDEYAIITVGRSARDFFKARQMNVVLEVQGITDHPIFAEIKDIASNTVQMFEDGVYDEVFIYYNHHINSISSELRKEQLLPLTEFHEKGKETDVDLTTYEFEPSEQEILEVLLPQYVESLIFGALLDAKAAEHAARMTAMRSATDNASDLISDLSLQYNRARQAAITQEITEIVGGAAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TYSY1_BACAM
Sequence: FDNSEVPILTTKKLAWKTAIKELLWIWQLKSNDVNDLNKMSVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVPV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase 1, TS 1, TSase 1, Thymidylate synthase A, TS A, TSase A.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JPH2_RAT
Sequence: MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPAADGPTLPLPPVPRGGFALSLLATAEAARPPGLFTRGALLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLVKGTKRRVLPLKSNKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLEPRERGPGTGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPGSSKDGLLSPGAWNGEPGGEGSRPATPSDGAGRRSPARPASEHMAIEALQPPPAPSREPEVALYRGYHSYAVRTGPPEPPPLEDEPEPEPEVPRSDSEPPSPVSATVQEEESPAPRSRVPAKPATLEPKPIVPKAEPKAKARKTEARGLSKAGAKKKGRKEVAQEAEAEVEVEEVPNTVLICMVILLNIGLAILFVHLLT
What is the function of this protein?
Transcription repressor required to safeguard against the deleterious effects of cardiac stress.  Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes.  Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis.  Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress.  Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.
What are the official names of this protein?
Junctophilin-2, JP-2, Junctophilin type 2.
What is the protein family that this protein belongs to?
Belongs to the junctophilin family.
What are the subcellular locations of this protein?
[Junctophilin-2]: Cell membrane; Peripheral membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. SUBCELLULAR LOCATION: [Junctophilin-2 N-terminal fragment]: Nucleus. Note=Accumulates in the nucleus of stressed hearts.