PharMolix/UniProtQA huggingface dataset:
Protein: FHR1_HUMAN
Sequence: MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
What is the function of this protein?
Involved in complement regulation.  The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.  Can associate with lipoproteins and may play a role in lipid metabolism.
What are the official names of this protein?
Complement factor H-related protein 1, FHR-1, H factor-like protein 1, FHL-1, H-factor-like 1, H36.
What are the subcellular locations of this protein?
Secreted.
Protein: FGM9_GIBZE
Sequence: MSGISFKSFVQSQYTPIPLPNHDFTGQTILITGASRGLGLEAASHFYRLNASKIILAVRDARKGPECIAFVRQYNPSSNTTVECWELDLTNVETIRQFVAKAKNLARLDAVILNAGMATMSFQAIDGMEKTLATNVTGTFLLAIGLLPALRLSGLRNNIRPRMVLVSSQGHEAAAFAERDADDIFAALNDADKTDMTDRYDTSKLIQLLAFYALKDTVDKSWPDSITFTAVDPGLCDTDLTRDIPLLIRIIHRIMKMLLARTAEVGGRCLVLGAADDEHSHGAYFKDGVIGSPPVAVTDPEGVELKNRVFSQLKSLLYSVDPQIMDACPVMESDEEAIRLN
What is the function of this protein?
Short chain dehydrogenase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501).  The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892).  During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892).  The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892).  Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892).  The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).
What are the official names of this protein?
Short chain dehydrogenase FGM9, C64 cluster protein NRPS5, Fg3_54 cluster protein FGM9, Fusaoctaxin A biosynthesis cluster protein FGM9.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: FHCA_METEA
Sequence: MLTRIHGGRVVDPTAGRDAVGDVWIEDGRVVAPSERAPDQTIDATGCVVMAGGVEVHSHIAGGNVVMSRLLLPDLYVSESAPNGHPFAHAGGSGSWIGANYARMGYTTAVEPALPPSNALATHLELADIPLLDRGGLAVLGNDDHLLQLLRDGEGKQAVRDLVQQTLAHSRGLGVKCINAGGASAFKDGVLKLSLDDEIPCYGLSTRKIMSALLDAVEEIGVPHPLHVHCNNLGLPGADDSLVATLEAAEGRRIHFAHAQFYAYGVVDPENPMTGGFRSAAERINAAMEAHPNATYDVGQVVFGQTVTISLDILRQFGGRKGAKPKKWVISAGDAEGGGVVPFLYRPRGPVSSLQWAIGLELMLLSSNPERTILTTDHPNGGVFTEYPRIIHLLMDAEERAKEIATLPAIVGERSGLPKIEREYSFSEIAQLTRSGPAKLLGLTDRGHLREGAKADVAIYRDDKDRTAMFSRAKLVLKDGQPIVEDGEVVAWFSGKTLSLDVEADAGMEKRAESYLQDRFGAGLDTFAVPDAAFPENTGTFEDVACRA
What is the function of this protein?
Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR).  May be catalyze the hydrolysis of formylmethanofuran (formyl-MFR) to yield formate and MFR.
What are the official names of this protein?
Formyltransferase/hydrolase complex Fhc subunit A, Ftr complex.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDA_SALG2
Sequence: MSSWVEVSLNTPAQLSLPLYLPDDETFASFWPGDNASLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECVAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDHASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: CDIA8_BURPE
Sequence: SLDTTGNVDLTSANVKAGSLDLNAGNKLILDTATQTTHQVSRDGATSDKTTLGPAANLNVAGDASIKTGGDFQQNAGNLNVGGNLNANIGGNWNLGVQQTGEHKVVQRANGVSDTDLNSATGSTVNVGGKSAIGVGGDLTAQGARLDFGQGGTVAAKGNVTFGAASTTSTINANSSGDQGNRSYAETRHGADQALTGTTVKGGDTLNVVSGKDINVIGSTIDLKKGDANLLAAGDVNVGAATETHVYNSRETHSRSGVVSGTKIASSQDATSTVANGSLISADGVSIGSGKDINVQGSTVVGTHDVALNAAHDVNITTSQDTSQSSTTYQEQHSGLMSGGGLSFSVGNSKLAQQNQSSSVTNNASTVGSVDGNLTVNAGNTLHVKGSDLVAGKDVTGTATNIVVDSATDTTHQAQQQQTSKSGLTVGLSGSVGDAINNAISETQAARESAKDSNGRASALHSIAAAGDVAFGGLGAKALLDGAKGPQAPSIGVQVSVGSSHSSMQSSEDQTIQRGSSINAGGNAKLIATGNGTPKDGNITIAGSNVNAANVALVANNQVNLVNTTDTDKTQSSNSSSGSSVGVSIGTNGIGVSASMQRAHGDGNSDAAIQNNTHINASQTATIVSGGDTNVIGANVNANKVVADVGGNLNVASVQDTTVSAAHQSSAGGGFTISQTGGGASFSAQNGHADGNYAGVKEQAGIQAGSGGFDVTVKGNTDLKGAYIGSTADASKNSLTTGTLTTSDIENHSHYSANSAGFSAGASVGVSTKAVGPSSVSGSGGVTPMVFQNDSGDQSATTKSAVSAGTINITKPGEQTQDVANLNRDTTNLNGTVSKTPDVQKMLSQQADTMNAAQAAGQTVSQAIGLYADYKRDAALDAADKAYKAGDLAGAQAALNEAKGWMEGGASRAELQMGGGALIGGLGGGSALTAIGGAAGAGTSSLLANQAEKISKSVGDTTGSSLVGNIAANVAATVGGALVGGSAGAAMASNVQLYNAGNDSNNQTSNDVFASLSKKVAQAIAMTADGKAGVWNGMVNVAGVIVNLPNGGPFASPGDPGYVSLDGLKKPYKSGTSIGPDAEFWTPVLATLGLGGKAAAGTGATTTSADAATVGNGALKTASGDLSAAGNAARTQPYGNGASASPSPGTATAGSSGANAQLPTANGGVAAAGTSSATNVGKVVIDGKIGGQLEARGWTQQEVQAVVNEGPVGTTMDNRSAGKTPDGLPRNDSASVYGSKSGYVVVNDRTGEVVQVSGKNDPVWIPDSRIKWK
What is the function of this protein?
The CdiA protein is thought to be exported from the cell through the central lumen of CdiB, the other half of its two-partner system (TPS).  The TPS domain probably remains associated with CdiB while the FHA-1 domain forms an extended filament with the receptor-binding domain (RBD) at its extremity; in the secretion arrested state the C-terminus of the RBD domain form a hairpin-like structure as the FHA-2, PT and CT domains are periplasmic.  Upon binding to a target cell outer membrane receptor a signal is transmitted to activate secretion.  The filament elongates slightly, the rest of CdiA is secreted and the FHA-2 domain becomes stably associated with the target cell's outer membrane where it facilitates entry of the toxic CT domain into the target cell periplasm.  From there the toxic CT domain is cleaved and gains access to the target cell cytoplasm via an inner membrane protein.
What are the official names of this protein?
tRNA nuclease CdiA, Toxin CdiA.
What is the protein family that this protein belongs to?
Belongs to the CdiA toxin family.
What are the subcellular locations of this protein?
Target cell, target cell cytoplasm. Note=Secreted to the cell surface by CdiB, its two partner secretion pathway (TPS) partner.
Protein: KAD_BURO1
Sequence: MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVPDALIIGLVKERLKESDCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGHDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGTVDEIRERAFDALK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
Protein: VL1_HPV35
Sequence: MSLWRSNEATVYLPPVSVSKVVSTDEYVTRTNIYYHAGSSRLLAVGHPYYAIKKQDSNKIAVPKVSGLQYRVFRVKLPDPNKFGFPDTSFYDPASQRLVWACTGVEVGRGQPLGVGISGHPLLNKLDDTENSNKYVGNSGTDNRECISMDYKQTQLCLIGCRPPIGEHWGKGTPCNANQVKAGECPPLELLNTVLQDGDMVDTGFGAMDFTTLQANKSDVPLDICSSICKYPDYLKMVSEPYGDMLFFYLRREQMFVRHLFNRAGTVGETVPADLYIKGTTGTLPSTSYFPTPSGSMVTSDAQIFNKPYWLQRAQGHNNGICWSNQLFVTVVDTTRSTNMSVCSAVSSSDSTYKNDNFKEYLRHGEEYDLQFIFQLCKITLTADVMTYIHSMNPSILEDWNFGLTPPPSGTLEDTYRYVTSQAVTCQKPSAPKPKDDPLKNYTFWEVDLKEKFSADLDQFPLGRKFLLQAGLKARPNFRLGKRAAPASTSKKSSTKRRKVKS
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: Y1015_ARATH
Sequence: MISKDHLHHLDPLGTTKSYHMNTSTVSPPSPASSISLSQSAWLEVRLFYVRIAPCVVENVPDFLTLRHPRRETGASLEVNGVRVPSSQTASLKLRRDRVDRESSEVTYVSTETVRVTGCVDFEVYDNEDMVLCGNLDRIEGAWNNGTVSDPKTGWGMDCYIAMGNGHVSGPSASVFFQPKFGVSSPSVEVYIAGCCGGVPVILTKTIQASPRRKVARHVTLDAIPEDEEVGKEQDIGTIGDELARQSKVQMMESEVDEYDDSDMKMAQRYYPEGMYVDEDGQLSWFNAGVRVGVGIGLGMCLGVGIGVGLLMRSYQATTSNLRRRFL
What are the official names of this protein?
Uncharacterized protein At1g01500.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IMDH_ECOLI
Sequence: MLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKESPNYRLGS
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: HAL1_YEAST
Sequence: MHFKDLGLHDYTLKNLMYENNCCKFYDAVDENNISYVLKFVPSDVTSEGDTFPFVDRFQVKEGVFLVYSSNDFGKEGTDYFTYTGSGGNEVHISGTSSEAGIKPQFIETCHPKHLKRGTKEQEDINSSTSKKSAVINNFSGEKTPNPRPQSSNISERETYVGILNVKCKNKNSSKIRSEKLVSSVIETKHTPGLASILSKEGTTYPNNADGKHISIVNPSSKIYHSSHKQIVKTPIPKSGLSPIERCPFNGQNIKCYSPRPLDHESPQRDFNNNFQLRILKSSVLQRRQSTQNS
What is the function of this protein?
Involved in salt tolerance.
What are the official names of this protein?
Halotolerance protein HAL1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXF2_MOUSE
Sequence: MSTEGGPPPPPPRPPPAPLRRACSPAPGALQAALMSPPPAATLESTSSSSSSSSASCASSSSNSVSASAGACKSAASSGGAGAGSGGTKKATSGLRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHGQGGYGGLDMMPAGYDTGAGAPGHAHPHHLHHHHVPHMSPNPGSTYMASCPVPAGPAGVGAAAGGGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHPSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM
What is the function of this protein?
Probable transcription activator for a number of lung-specific genes (PubMed:9676429).  Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (By similarity).
What are the official names of this protein?
Forkhead box protein F2, Protein LUN.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS13_NOCSJ
Sequence: MARLVGVDLPRDKRIEIALTYIYGIGRTRAQQVLEATGVNPDLRVHQLGDEELVKLRDEIEANFKIEGDLRREVQADIRRKIEIGSYQGRRHRQGLPVRGQRTKTNARTRKGPKRTVAGKKKAK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MIAB_COLP3
Sequence: MSKKLYIKTWGCQMNEYDSQKMAELLDSTHGFSLVEEAEQADVILLNTCSIREKAQEKVFHQLGRWKNLKDKKPDLLIGVGGCVASQEGDSIRKRAPFVDMIFGPQTLHRLPEMLNQLQHSKSPIIDVSFPEIEKFDRLPEPKADGASAFVSIMEGCSKYCTFCVVPYTRGEEVSRPLDDVLYEIAQLAEQGVREVNLLGQNVNAYRGETHDGSICRFADLVRLVATIDGIDRIRYTTSHPVEFTDDIIEAYTDVPELVNHLHLPVQSGCDRILTQMKRGHTALEYKSQIRKLKKVRPELSMSSDFIIGFPGETDEDFTATMDLIKAVDFDLSFSFIYSARPGTPAADLPDDISDQTKKDRLKLLQEQITHQALRIARQMLNTEQRVLVEGPSRKNPMELRGKTENNRTVNFVAPHSVIGQFVDIKITDVVANSLRGELVREEKEMGLRIAHSPADILANNHHMATPSNLDELGVGTFTP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPMA_YERPY
Sequence: MSDTASWQPSAPIANLLKRAAIMAEIRRFFADRGVLEVETPTMSQATVTDIHLVPFETRFVGPGAADGLTLYMMTSPEYHMKRLLAAGSGPIYQLGRSFRNEEAGRYHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQILDCNSAETLSYQQAFLRHLNIDPLSAEKAQLREVAAKLDLSNIADTEEDRDTLLQLLFTVGVEPYIGRDKPAFIYHFPASQASLAEISTEDHRVAERFEVYFKGIELANGFRELTDGDEQLQRFEQDNRNRAKRGLPQNPIDMNLIAALKQGLPDCSGVALGVDRLVMLALNAERLSDVIAFPVNIA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P).  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: COAD_BURM1
Sequence: MVVAVYPGTFDPLTRGHEDLVRRASSIFDTLVVGVADSRAKKPFFSLEERLKIANEVLGHYPNVKVMGFKGLLKDFVRTNNARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVEKWLTEKVAAMGGPAA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXGA_NEOFI
Sequence: MIFKFSQKALVALCLVVGLAEAVPSKSRVVSRASTFDYNGIVRGVNIGGWLVLEPWITPSIFDNAGDAAVDEWTLTATLGQDQAKAVLSQHWSTFITQGDFHRIAQAGMNHVRIPIGYWAVSSLPDEPYVDGQLEYLDNAISWARDAGLKVVIDLHGAPGSQNGFDNSGRKGPIAWQQGNTVSQTVDAFRALAERYLPQSDVVAAIEALNEPNIPGGVSEAGLRDYYDQIADVVRQINPDTSVFLSDGFLSTASWNGFKTGEDVVMDTHHYEMFDNYLISLDIHGHVKSACDFGKQIKGSDKPVVVGEWSGAVTDCTKYLNGKGVPTRYQGEYANNPKYGDCGDKTQGSVADLSDQERADTRRFIEAQLDAYEGKNGWLFWTWKTEGAPGWDMQDLLANGVFPSPLTDRQFPNQCA
What is the function of this protein?
Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall.  It could also function biosynthetically as a transglycosylase (By similarity).
What are the official names of this protein?
Probable glucan 1,3-beta-glucosidase A, Exo-1,3-beta-glucanase 1, Exo-1,3-beta-glucanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNC_CAEEL
Sequence: MSDEKISMTLNFPKHKRARRKKYQKEYQERHKEEMMQQLGRRFQNQPSTSSAPPDTVEKIPLPTESTSALPFGDSPRLTEKDYETNYMIDPPVVSTHSAELIKSNRVVIKAEEAEKYMMIKAKSTTSKILQDFQTKILETVKTKRRLQADVPYIIHPCHSMKGRKTPKQKGGDESFTASDVSDDSNDSQDEASTSEPTNRQAPEADKTGEVKDEKQTCNRRNQQRKAKRLRNFEEKERQITLLKKGIDRKKTHPNGIHPDISFNEKGLGNEGPECRCPEPIKTCGLKHGYYAGEDKAIDCKKSNGENLHYYTLRVTPLPSENQLYRTHMAINGEEFEFEGFSLITHAPLPDCMTRAPICKYSMDYEFQLVEEFMPDECFDPEDCDMLFEYIFHEIFEMLDFELRPKHIPSDVESCPMIHIMPRFVQTKDDLVQLWSSKTVLAYFTSKGSSEIMSPEDVNRLCDAQIDQFTRNTSKHKQSIVLNTKFKPSAIRADWFERDEEKKEVYVVHNAIRAQTYTAISLPRIAFLEKTLNKMIQEKQSSGVYNKDFEKTKNELEHLKRENRSARNLKLREPVAGFIETGLKPDVAAHVVMTILACHHIRYNFSLDVFEEVIEYKFNDRRVIELALMHSSFKSHYGTPIDHVKNMITNCGYRRKYGAEDKREKKRVAGIMSLFNIMKGTSGGEPILHNERLEYLGDAVVELIVSHHLYFMLTHHFEGGLATYRTALVQNRNLATLAKNCRIDEMLQYSHGADLINVAEFKHALANAFEAVMAAIYLDGGLAPCDVIFSKAMYGHQPVLKEKWDHINEHELKREDPQGDRDLSFITPTLSTFHALEERLGIQFNNIRLLAKAFTRRNIPNNDLTKGHNQRLEWLGDSVLQLIVSDFLYRRFPYHHEGHMSLLRTSLVSNQTQAVVCDDLGFTEFVIKAPYKTPELKLKDKADLVEAFIGALYVDRGIEHCRAFIRIVFCPRLKHFIESEKWNDAKSHLQQWCLAMRDPSSSEPDMPEYRVLGIEGPTNNRIFKIAVYYKGKRLASAAESNVHKAELRVAELALANLESMSFSKMKAKNNSWFQNMRRRLEQDTSD
What is the function of this protein?
Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA.  Involved in pre-rRNA processing.  Cleaves double-strand RNA and does not cleave single-strand RNA.  Involved in fertility.  Required for the function or synthesis of the let-7 miRNA.
What are the official names of this protein?
Ribonuclease 3, Protein drosha, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SCN3A_RAT
Sequence: MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDIDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYVSKKTFVVLNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCSQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNHRADGDRFPKSESEDSVKRRSFLLSLDGNPLTGDKKLCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRPGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRSMSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTQQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKNKIRECFRKAFFRKPKVIEIQEGNKIDSCMSNNTGIEISKELNYLKDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVAPPREGEQAEIEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGNMFEIKEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPIYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCYLLKQRLKNISSKYDKETIKGRIDLPIKGDMVIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEKFEKDKPEKEIKGKEVRENQK
What is the function of this protein?
Mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (By similarity).  May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity).  In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity).
What are the official names of this protein?
Sodium channel protein type 3 subunit alpha, Sodium channel protein brain III subunit alpha, Sodium channel protein type III subunit alpha, Voltage-gated sodium channel subtype III, Voltage-gated sodium channel subunit alpha Nav1.3.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CRGM2_CHIID
Sequence: MGKVIFYEDRNFQGRHYECSSDCADLSPYFSRCNSIRVEGGCWVLYEKPNYMGYQYFLTRGEYPDYQRWMGFNDTIRSCRIIPQYRGSYRMRIYERPDFGGQMMEFMDDCPSVYDTFRYRDIHSCHVMDGYWIFYEHPSYRGRQYFMRPGEYKKFSDWGATCPTIGSFRRIMDSWY
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin M2, Gamma-M2.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: Y1241_AQUAE
Sequence: MKWIFLLLSLLIYSCQELPKKYQTPEGKKILEKYKKQYVKGVVILDDKLKEKIPKGERYLIIAVMKEGSSRPVAVLRVKNPDFPYRFKITGKHKIVPEDFIEGKLMLTARISKEPTAGFKRGDLYGFAQAQAGDEDVKILINQVFEEKEK
What are the official names of this protein?
Uncharacterized protein aq_1241.
Protein: CAE12_RANCI
Sequence: QQDYTGWFDF
What is the function of this protein?
Hypotensive neuropeptide.
What are the official names of this protein?
Caerulein-1.2/1.2Y4.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNMA_EDWI9
Sequence: MSDNSQKKVIVGMSGGVDSSVSAYLLQQQGYQVAGLFMKNWEEDDSDEYCSAATDLADAQAVCDRLGIELHTVNFAAEYWDNVFELFLQEYRAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRRDINGTTQLLRGVDANKDQSYFLYTLSHQQVAQSLFPVGELEKPEVRRIAAQLDLATAKKKDSTGICFIGERKFREFLGRYLPAQPGKIVTVDGETIGEHQGLMYHTLGQRKGLGIGGTKEGSEEPWYVVDKDLDNNVLVVAQGHDHPRLFSNGLIAQQLHWVDRLPLGAPLRCTVKTRYRQADIPCLVTPLADERIEVRFDQPVAAVTPGQSAVFYQDEVCLGGGIIETRLVD
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.