PharMolix/UniProtQA huggingface dataset:
Protein: CY551_PSEFC
Sequence: EDGAALFKSKPCAACHTIDSKMVGPALKEVAAKNAGVKDADKTLAGHIKNGTQGNWGPIPMPPNQVTDAEALTLAQWVLSLK
What is the function of this protein?
This is a prokaryotic monoheme cytochrome, unreactive with mitochondrial cytochrome C oxidase or reductase.  It functions in nitrite and nitrate respiration in Pseudomonas, but it is also found in other bacteria.
What are the official names of this protein?
Cytochrome c-551, Cytochrome C8, Cytochrome c551.
Protein: METAA_RUEPO
Sequence: MPIKIPAHLPAYDILTREGVMVMSEDQAARQDIRPLRIGLLNLMPKKIQTETQFARLIGATPLQIELSLIRMTEHQTKTTASEHMEEFYRPFQEVRDEKFDGLIITGAPIEHLEFSDVTYWDELGEVFAWTQSNVHSTFGVCWGGMAMINHFHGIRKHMLDHKAFGCFRHRNLDPASPYLRGFSDDFVIPVSRWTEVKQAEVDAVPELVTLLGSDEVGPCLISDPGHRALYIFNHFEYDSDTLKQEYDRDVEGGTAINVPINYYPDDDPSRKPLNRWRSHAHLLYGNWISEIYETTPYDMARIGLESTDLRG
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_IDILO
Sequence: MIEADQIPTQRLIEPEVQGEDEAVDRAIRPKTLADYTGQKHVVEQMGIFIEAARKRQEALDHLLIFGPPGLGKTTLANIVANELDVSIKTTSGPVLEKAGDLAALLTNLEAHDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGALTSPLRDRFGIVQRLEFYDVNELTDIVGRSAHFMNVRMLDGGAREIARRSRGTPRIANRLLRRVRDYAEVRGNGDVDEVTANAALTMVDVDQAGFDYMDRKLLLAIMEKFMGGPVGLDNLAAAIGEEKDTIEDVLEPYLIQQGFLQRTPRGRIATPRAYQHFGLKPEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: UVRC_PROA2
Sequence: MPDQPLNRTTIPEKKLSNLPTCPGVYQFKNNQGTIIYVGKAKNIRSRVRSYFREGPHISGKTKVLVNHIADIDIILTSSEVEALILENNLIKDLKPRYNINLKDDKTYPYLVITNEAFPRILITRQVKRDGSTYFGPYTEARQLRSVLDLISTIFPVRKCKLKLTKENIESGRFSVCLNYHIHTCKGPCEGKQREEDYLRMIEEIKGLLKGKTGALIRTLSAEMHRYADELRFEEAAELKIQIEGLRKYTERQKVVSKDPVDRDVFGIAQHQDDACGVIFKIREGKLLGSQRMYFSNVDDEQHETLLRKCLEKYYLETPDLIPQEIFLPLPIDDDEVMALRELTGDINLRFIVPKIGEKAKLVAMCIDNARHHLEEYLIEKQKRGELSRIVPALQALQETLHLSRQPERIECFDNSHFQGTDYTSSMVCFVGGKPRKSDYRKFKLNSFEGSDDYAAMQEAVTRRYSGSLQDELPLPDLIVIDGGKGQVNTAWKVLQELGLEIPVIGLAKRLEEIFLPNTPDPYNLAKTSPALKLLQQIRDEAHRFAITYHRKLRTKRTIQTGLTDIAGIGEKSAMKLLEHFGSIEQIAKAEKEEILAVTGPKTAEAILSYFRKKQP
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_BURP1
Sequence: MAELATIARPYAEALFRVAEGGDISAWSTLVQELAQVAQLPEVLSVASSPKVSRTQVAELLLAALKSPLASGAQAKNFVQMLVDNHRIALLPEIAEQFEALKNAREGAADVQIVSAFPLEGAQLAELVTSLERKFKRKLKPAVEVDSSLIGGVRVTVGDEVLDTSVRARLAGMQAALTA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: U499_NEOFI
Sequence: MKSFNLLSLSLLLAIASAAAVPDVEGTITNDAATPVNNLDDKRDHCGQVCLNKTGCGGKCPKCDMRSLTCKKA
What are the official names of this protein?
UPF0499 protein NFIA_054990.
What is the protein family that this protein belongs to?
Belongs to the UPF0499 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACCD_DESAP
Sequence: MFKKSKYFTVRPETKREIPEGLWIKCQCGAILFAKDLERNLKVCQKCAHHFRLTARERIRITLDTEDFEELDAGLAPRDLLGFPGYAERLAANQKQTGLNEAAISAEGTIGGHRVVLVVMDSHFIMGSMGTVVGEKVARAAEHAVRNRLPLIVFSASGGARMQEGILSLMQMAKTAAAIGRLDSAGLLYVSVLTDPTMGGVSASFAFLGDIILAEPGALIGFAGPRVIEQTIRQKLPDGFQQAEFLQEHGFVDAVVPRSRLKDTLIKIIGMHQAG
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CO112_SCHPO
Sequence: MPILTCRYKILFLYNLRNCFTFQNQRCLIPYGTTTTIRWYNANFQAVQNNFSDYKNELISSHRPEASSLLDFLVKDQKKSGDISLHTKFNLYVDDLLKKSEKGQIKKFINDIKKDLATESQLPLSAPFKDESTRTMTDPQVLAYIHQSMPYQYASLYSVLTDLKIVNSDVSCKSQHILDCGKGPGIGALASYSVFPTPNSVSIVEENPFLKKIIYDIHHNIYPSTSPNPTSPVTLNRLPLGKKDSYTLVIASNKLLEMKSEKELFDYLRSLWSLVSNDGGLLVLCERGTKRGFSLIQRARTFLLQKSKNTSDKQFNAHIVAPCPHDGRCPIDIENGVRANICSFKQHFFLSPFSRLYVPRSHRRSSDRSHYSYVVIQKGITRPLNNTTQRFKNDEDLLENVNVTSPTLKNWPRIIRPPLKRDGHVIIDVCDSDARLRRNIVPKSQGKLAYRLARKSAWGDLFPLEGKVQSTSPSSKITKHLKDASSTYSINPPSYNKPKVERNTTADPIFVGKRFYSTNRHKAFSRFADFNSHRFPCIFTSFSCYNCISGTRNISRQYSRDKFHYNQRTTIYYLVAISIFALGLTYAAVPLYRLFCSKTGYGGTLNTDQSRMNAERMVPRKDNKRIRVTFNGDVAGNLSWKLWPQQREIYVLPGETALGFYTAENTSDHDIVGVATYNIVPGQAAVYFSKVACFCFEEQKLDAHEKVDLPVFFFIDPEFADDPNMKDIDDILLSYTFFEARYDTNGNLLTKLN
What is the function of this protein?
Cox11-2 exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
What are the official names of this protein?
Rsm22-cox11 tandem protein 2, mitochondrial.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the COX11/CtaG family.
What are the subcellular locations of this protein?
[37S ribosomal protein S22-2]: Mitochondrion matrix. SUBCELLULAR LOCATION: [Cytochrome c oxidase assembly protein cox11-2]: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Protein: SYP_PAEAT
Sequence: MVLRLSQLFLRTLREDPVDAEVDSHKLLVRAGYIRRAAPGIYTWLPLGLSVLRKVEDIIRQEMSAIGAQEVHFPALLPREPYEATNRWTEYGEGLFRLQDRKGADYLLAPTHEEMFTLLVKDLYSSYKDLPLSLYQIQNKYRDEARPRAGLLRGREFIMKDSYSFDIDDAGLDASYAAHRAAYLKIFERLGLEVIPVAATAGAMGGSKSEEFLFPTEIGEDTFVRSAGGYYANVEAVTTVVPDEIDFSNAPAAEVLDTPNTPTIDTLVDAANQLAPRSESDGGAWTAADTLKNVVLAVTLPTGERQIVVIGVPGDRGVDLKRVEANIGSHLPIAGEIGLEAANEEDLKKLPWLVKGYIGPGLSLDEPVLGLEGSSKVLFLVDPRVVSGTTWVTGANAEGKHVFGLVAGRDFVWDGVIESTEVRAGDPAPDGSGPLETARGIEMGHIFQLGRKYAEALDLKVLDQNGKQQVVTMGSYGVGVTRAVAALAEANNDDRGLVWPRSVAPADVHVVAVGRGDEIFEAAEKLSLELEAAGLDVIFDDRPKVSPGVKFGDAELVGVPTILAVGRGLVDGVVEIKDRRSGEAENISVDKAVDYVVNAVRTR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF205_ASFP4
Sequence: MVEPREQFFQDLLSAVDQQMDTVKNDIKDIMKEKTSFMVSFENFIERYDTMEKNIQDLQNKYEEMAANLMTVMTDTKIQLGAIIAQLEILMINGTPLPAKKTTIKEAMPLPLSNTNNEQTSPPASGKTSETPKKNPTNAMFFTRSEWASSNTFREKFLTPEIQAILDEQFANKTGIERLHAEGLYMWRTQFSDEQKKMVKEMMKK
What is the function of this protein?
Induces host endoplasmic reticulum stress and consequently activates autophagy and NF-kappa-B signaling pathway.  In turn, may induce autophagy-mediated STING1 degradation and innate immune evasion.
What are the official names of this protein?
Uncharacterized protein K205R, pK205R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus K205R family.
Protein: PLSX_HELP2
Sequence: MKIVIDLMGADHGVLPIIEGVSRALENKSFSAVLVGDKDKATPFISKELASKVEMIHTQDYIKMEEAATEAIKRKESSIYLGMDILKNGADALISAGHSGATMGLATLRLGRIKGVERPAICTLMPSVGKRPSVLLDAGANTDCKPEYLIDFALMGYEYAKSVLHYDIPKVGLLSNGEEDIKGNMLVKETHKMLKAYDFFYGNVEGSDIFKGVVDVVVCDGFMGNVVLKTTEGVASAIGSIFKDEIKSSFKSKMGALMLKNAFGILKQKTDYAEYGGAPLLGVNKSVIISHGKSNARAIECAIYQAISAVESQVCLRITQAFESLKPSVSVHQSDQQDA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: DSC2_BOVIN
Sequence: KFIGRVNLKECFKSATLIHSSDPDFQILEDGSVYTTHAILLSSEKSSFTILLSNTETQEEKEILVLLEHQTKVLKKRHSQEKVLRRAKRRWAPIPCSVPENSLGPFPLFLQQIQSDTAQNYTIYYSISGPGVDKEPRNLFYVERDTGNLFCTASIDRETYPLFELVAFATTPDGYTPEYPLTLVIRIEDENDNAPIFTETSYSFEVFENSKVGTTVGQVCATDQDEPDTLHTRLKYSIIEQFPALPTLFSMHPTTGVITTSSSKLDRELIDKYQLKIKVQDMDGQYFGLQTTAICIINIEDVNDNLPTFTRSSYVASVEENRIDVEILRVAVRDKDLINTANWRANYTILKGNEDGNFKIVTDSQTNEGVLCVVKPLNYEEKQQVTLEIGVVNEAPYTGTSRSTTNMATVTVNVQNQDEGPECDPRVQTVRIKENVPVGTKTIGYKAYDPETGSSSGIRYKKSSDPEGWVDVDKNSGVITILKRLDREARSGVYNISIIASDKDGRTCNGVLGIVLEDVNDNGPVIPQRTVVICKTVMSSAEIVAVDPDEPIHGPPFDFSLEGVSDSEVLRMWRLTKVNDTAARLSYLNDLRFGKYTVPVRVTDRLGQSLVTQLVVILCDCVTPNDCSFRPVSRTGNREVILGKWAILAILLGIALLFCILFTLVCGATTGADKKPKVFPDDLAQQNLIVSNTEAPGDDKVYSTNDFTTHAVGGSAHGIGGTLGSRVKNGGQETIEMVKGGHQTMESCQETGHDHTLERCKEGGQHTLDSCRGGPVATDNCKYTYSEWYTYTQPRLGEKVQQCDQDNTHMQAQDYVLTYNYEGRGSAAGSVGCCSERQEEDGLEFLDHLGPKFRTLAETCMKR
What is the function of this protein?
Component of intercellular desmosome junctions.  Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.  May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
What are the official names of this protein?
Desmocollin-2, Epithelial type 2 desmocollin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Protein: ATPD_CITK8
Sequence: MSEFVTVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENNRLNALPDVLEQFIHLRAASESTSEVEVTSATALSEEQLAKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MSRP_ANAD2
Sequence: MARWRPDMAEREATPEALYLRRRDFLALGAAGAVGLLLPRGARAGDPTGAALQVARKVDQAGGETPTPWDSVTGYNNFYELGTSKEDPSRNAGSLRARPWTVTIAGEVKRPQTLDVDALVRMFPPEERVYRMRCVEAWSMVIPWVGFPLADLVRRLEPTSRAKYVAFQTLLDRDQLPGQRRPVLPWPYVEALRIDEANHPLALLAVGLYGRVLPGQNGAPLRLVVPWKYGFKGAKSIVRITFLADRPHTTWNDAAPDEYGFYANVNPEVDHPRWSQARERRIGEFFRRKTLPFNGYAAEVAPLYAGLDLRKNY
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: RS7_SHIB3
Sequence: MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAESIVYSALETLAQRSGKSELEAFEVALENVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLANELSDAAENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: FZR1_HUMAN
Sequence: MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR
What is the function of this protein?
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex.  Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase.  The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely.  At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C.  Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.  Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.  Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).
What are the official names of this protein?
Fizzy-related protein homolog, Fzr, CDC20-like protein 1, Cdh1/Hct1 homolog, hCDH1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CDC20/Fizzy family.
What are the subcellular locations of this protein?
[Isoform 2]: Nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Protein: YB51_ENCCU
Sequence: MLLCLLYFTSSWCSGSDVPDVCTNSGMIAINFVDGPVRGVTDRILNTLDELGVKATFSFTVNQKAVGNVGQLYRRAVEEGHNVALRVDPSMDEGYQCLSQDALENNVDREIDTIDGLSGTEIRYAAVPICNGQVNSEMYNILTERGVLPVGYTFCPYDYDDPVGEFESMIEGSDPKHHSFIILMHDGQEADTSRLENMVKIGKDKGYRFVNMDECLQGYKGAPGDPELSLRGKGVESIGKGFLPFFLMMLVRLL
What are the official names of this protein?
Polysaccharide deacetylase domain-containing protein ECU11_0510.
Protein: UBA5_DROWI
Sequence: MSAIDELQALIVELKSELEAQKTETRQQQAQAQQARQRIDRMSAEVVDSNPYSRLMALQRMNIVKDYERIREKTVAVVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNRLFFTPDQAGLSKVEAAARTLTFINPDVKIETHNYNITTVDNFDNFLTTISQSGTEPGTPVDLILSCVDNFEARMAINAACNEHSLNWFESGVSENAVSGHIQFIRPGDTACFACAPPLVVAENIDERTLKREGVCAASLPTTMGITAGFLVQNALKYLLNFGEVSDYLGYNALNDFFPKMTLKPNPQCDDRHCLLRQKEFQTKPKPVKKEVEIVAEEPLHATNEWGIELVAEDAPATEDADEPKPIVSDIGEGLRLAYEAPSKSTETTSEATTTTTGDETSLDDLMAQMKSM
What is the function of this protein?
E1-like enzyme which activates UFM1.
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme 5, Ubiquitin-activating enzyme 5.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
Protein: ATPL_SHESA
Sequence: METILGMTAIAVALLIGMGALGTAIGFGLLGGKFLEGAARQPEMAPMLQVKMFIVAGLLDAVTMIGVGIALFMLFTNPLGAML
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COX2_COPC7
Sequence: MNIVNSLDLSNITTNHVAAAVCAGIAVYAIVAGRNRGKKYPPGPKGHPLIGSLFEMPIQNAHVVYKEWAKTYGDMIFFKVLGQPFLILSSEETITDLLDKRSTIYSSRPRMPMVVELMGWDYTLGLLPYGERWRFLRREFHRFMSPTAVSNYRQIQENSVYTFLNNLVESPEQFSKHLRLFYGSISMKVSYGINVKSAEDQYLLDAEGAMSGFMEAGIPGRFWVDLFPALKYVPSWMPGAEFKRKAARWARLNDISLERPFKHVLDQLKKGVASQSVSATLIEELPDQNSPDRKEKETIARNISATTFLAGIDTIHSTTQAFFYAMAQFPEVQKKAQAEIDAVVGDKRLPTFEDRDQLPYVNALVKELIRWSEVAPLGIYHSTTEDDEYKGYFIPKGTIVMTNAWSILTDPVTYPDPFAFKPERYLKNGVMNPDAPRPEDLAFGRGRRICPGRYLADETLFMTSVGVLAGFNISPPLDKSGKPIKLKNERVGTITLTPPKFECRIEPRSPAIRTMIHDTAESISAL
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of alpha-cuprenene and oxidized derivatives (PubMed:19400802).  The alpha-cuprenene synthase COP6 is the only sesquiterpene synthase identified in C. cinereus that appears to be part of a biosynthetic gene cluster and is highly specific since it catalyzes the cyclization of (2E,6E)-farnesyl diphosphate into only one product, alpha-cuprenene (PubMed:19400802, PubMed:20419721).  The cytochrome P450 monooxygenase COX2 then oxidizes the cyclohexadiene ring of alpha-cuprenene at positions 1 and 4, yielding first alpha-cuparene, followed by alpha-cuparophenol and a further yet unidentified compound resulting from one additional oxidation step (PubMed:19400802).  The cytochrome P450 monooxygenase COX1 then likely catalyzes the oxidation at position 9 of the pentane ring of alpha-cuprenene to give the corresponding hydroxy or ketone derivatives (PubMed:19400802).
What are the official names of this protein?
Cytochrome P450 monooxygenase COX2, Alpha-cuprenene oxidase 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LRC25_HUMAN
Sequence: MGGTLAWTLLLPLLLRESDSLEPSCTVSSADVDWNAEFSATCLNFSGLSLSLPHNQSLRASNVILLDLSGNGLRELPVTFFAHLQKLEVLNVLRNPLSRVDGALAARCDLDLQADCNCALESWHDIRRDNCSGQKPLLCWDTTSSQHNLSAFLEVSCAPGLASATIGAVVVSGCLLLGLAIAGPVLAWRLWRCRVARSRELNKPWAAQDGPKPGLGLQPRYGSRSAPKPQVAVPSCPSTPDYENMFVGQPAAEHQWDEQGAHPSEDNDFYINYKDIDLASQPVYCNLQSLGQAPMDEEEYVIPGH
What is the function of this protein?
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation.  Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164).  Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
What are the official names of this protein?
Leucine-rich repeat-containing protein 25, Monocyte and plasmacytoid-activated protein.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cytoplasm.
Protein: RL18_AROAE
Sequence: MNKKEVRLRRARKTRAKIAELKSVRLTVFRTNSHIYAQVIDGSGSRVLAAASTVEADVRSQLPNGGNKQAAQVVGKLIAERAKAAGVEAVAFDRAGFQYHGRVKALAEAAREGGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: GALSF_BACTN
Sequence: MKNVSRLLPLLPGIALLTGCNQKVQKDNGQNSQKPNIIYIFADDLGIGDLSCYGATKVSTPHIDRLAGQGVQFTNAYATSATSTPSRFGLLTGMYPWRQENTGIAPGNSELIIDTACVTMADMLKEAGYATGVVGKWHLGLGPKGGTDFNGHITPNAQSIGFDYEFVIPATVDRVPCVFVENGHVVGLDPNDPITVNYEHKVGDWPTGEENPELVKLKPSQGHNNTIINGIPRIGWMTGGKSALWKDEDIADIITNKAKSFIVSHKEEPFFLYMGTQDVHVPRVPHPRFAGKSGLGTRGDVILQLDWTIGEIMNTLDSLQLTDNTILIFTSDNGPVIDDGYQDQAFERLNGHTPMGIYRGGKYSAYEAGTRIPFIVRWPAKVKPNKQQALFSQIDIFASLAALLKQPLPEDAAPDSQEHLNTLLGKDYTSREYIVQQNLNNTLAIVKGQWKYIEPSDAPAIEYWTKMELGNDRHPQLYDLSADPSEKNNVAKQHPEVVRELSELLESVKTR
What is the function of this protein?
Exosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS).  Catalyzes the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units (PubMed:25002587).  GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B. thetaiotaomicron in the host gastrointestinal tract (PubMed:25002587).
What are the official names of this protein?
N-acetylgalactosamine-6-O-sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
Protein: BGL39_ARATH
Sequence: MKFRALGLVLLLAVETCKAEEITCEETKPFTCNQTDRFNRKHFDDDFIFEGGKGRGLNVWDGFTHRYPEKGGPDLGNGDSTCGSYEHWQKDIDVMTELGVDGYRFSLAWSRIAPRESNQAGVKYYNDLIDGLLAKNITPFVTLFHWDLPQVLQDEYEGFLNHEIIDDFKDYANLCFKIFGDRVKKWITINQLYTVPTRGYAMGTDAPEPYIVAHNQLLAHAKVVHLYRKKYKPKQRGQIGVVMITRWFVPYDSTQANIDATERNKEFFLGWFMEPLTKGKYPDIMRKLVGRRLPKFNKKEAKLVKGSYDFLGINYYQTQYVYAIPANPPNRLTVLNDSLSAFSYENKDGPIGPWFNADSYYHPRGILNVLEHFKTKYGNPLVYITENGELLILSGCNVKGYFAWCLGDNYELWPSRSFHVSPFYLLHRKDKGAFPSFEA
What are the official names of this protein?
Putative myrosinase 3, Beta-glucosidase 39, AtBGLU39, Sinigrinase 3, Thioglucosidase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.