PharMolix/UniProtQA huggingface dataset:
Protein: SFH5_CRYNJ
Sequence: MSAVEAPSASQAIWPELTEDHPLSQLNSRLPTILSEAGHSQIWGVTLTYSTPPTFSSLIILQKFLRSVDNNVDEAATALGKTLKWRKDWGLDARADKKEKENFGPDFEGLGYVTKIKKNDGGDEIVTWNVYGAVKDLKSTFGDLDRFLRWRVNLMEEAIAHLHLATTSTPIPDFNAGIDPHRMAQVHLYEGVSFLRMDPHVKAASKATIELMAANYPELLSRKFFVGVPLIMSWMFQAVRMFVSAETAKKFVVISYKENLANELGELEGVPKEYGGKGLSLGELQNQLRGEDAVTSS
What is the function of this protein?
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity.  Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.  Heme-binding protein that may play a role in organic oxidant-induced stress responses.
What are the official names of this protein?
Phosphatidylinositol transfer protein SFH5, PITP SFH5.
What is the protein family that this protein belongs to?
Belongs to the SFH5 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: RL33_BORGP
Sequence: MGKKKGKGAVELISLICEETGIRNYTTTKNRRNKQEKLELMKYCPKLRKHTLHKEGKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: CC2H3_TRYBB
Sequence: MTMLGALTGRQLSSGLKDQFDRYNRMDILGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTALREVSILQEIHHPNIVNLLDVICADGKLYLIFEYVDHDLKKALEKRGGAFTGTTLKKIIYQLLEGLSFCHRHRIVHRDLKPANILVTTDNSVKIADFGLARAFQIPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSIGCIFAELARGKVLFRGDSEIGQLFEIFQVLGTPMDAEGSWLGVSSLPDYRDVFPKWSGKPLTQVLPTLDGDAVDLLSQMLRYNPAERISAKAALQHPWFSDAMF
What is the function of this protein?
Probably involved in the control of the cell cycle.
What are the official names of this protein?
Cell division control protein 2 homolog 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: LNKN1_CAEEL
Sequence: MKKILPIIWLINLVSGSLSLEKKAPDLLGKVCAFGDFNADRNTDILVFANGTLTINYQETKLLDVLEASKFTPGTSFAISKPSLNADFVECSVGDFNGDSRLDVLVSIRDKDTEIYNHTLWTSEIEDEKEIFRPFHVAMLQQHAMAIDVSDDGWTDVLGFYPNGSMFCTGFNKEGKYNLLVNGCKHEFVAFPEKLNIYPGMPHLFVDLNSDLIADIVFMTKESDGSLFMSVWQKTKISWQFRDWVPKLTPAQYPFVGAPVVMDVDSDGELDILVPICREDECSHITQMASWSKTKLWGLVACDMQDYTVIKEPFSRVIFRVGEFSLDSFPDMVVIAQATRANTRPVIKVMDNAECTKCEKNGTRRFEIRAQENIQPKNMSLGVIKMGTFFDLLEDGSLDLLVEYEYGGQTRFGFIYCPDKGDTTFLKVQVFTGVCSDRCNPKSNEIGSSISMTGACASFSMTDGWGGSTQSVACQVPASSNRALYLPFLLYGLGRSPNFVDELNIAIPKYADRKEDWKHSLKQIVPNSRIIVLPPSDQYPHWTSRLYVTPSALIVQSLAVIALVCCMLLMVVVFLHYREKKEDRYERQQQSHRFHFDAM
What is the function of this protein?
Probable cell adhesion protein involved in gonadal cell migration.
What are the official names of this protein?
Protein linkin.
What is the protein family that this protein belongs to?
Belongs to the TIP family.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein. Lateral cell membrane; Single-pass type I membrane protein.
Protein: PCKA_ALIFM
Sequence: MTVMEHKKAALLDLTQYGLTGVTDVLRNPSYEQLFEEETRPDLEGYERGVMTELGSVAVDTGIFTGRSPKDKYIVKDNTTKDTLWWSDQGKNDNKAITPAVWDDLRSLVTTQLSGKRLFVIDGFCGANPDTRLNVRIITEVAWQAHFVKNMFIRPTEAELENFEPDFVVMNGAKATNPNYEKHGLNSENFVAFNLTERVQIIGGTWYGGEMKKGMFAMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLSGTGKTTLSTDPKRQLIGDDEHGWDDDGIFNFEGGCYAKTIRLSKEAEPDIYNAIRRDALLENVTVRSDSSIDFNDGSKTENTRVSYPIYHIDNIVKPVSKAGHAKKVIFLTADAFGVLPPVAKLTPEQTKYHFLSGFTAKLAGTERGITEPTPTFSAAFGAAFLTLHPTQYAEVLVKRMEAAGAEAYIVNTGWNGTGKRISIQDTRGIIDAILDGSIDQAKTKNIPVFNLEVPTSLPGVDASILDPRDTYTDPLQWDSKAEDLAQRFIKNFAQYTDNEEGKALVKAGPQL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_HAES1
Sequence: MTLEQTLAIIKPDAVERNLIGNIISRLEDKGFQIIAMKMLHLNQEQAEGFYTEHSDKAFFAELIRYMTSAPIVVLVLQKENAVKDYRTFMGTTNPEIAENGTLRYEFAINQTQNSVHGSDSLENAQREIAYFFAEAEIYAR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AFSY1_CUCME
Sequence: MSSNISAIPNSLEVIRRSAQFQASVWGDYFLSYHSLSPEKGNKVMEKQTEELKEEIKRELNSTTKDEEPEKLRLIDSIQRLGVCYHFEYEINKILEQLHHITITSKNNGDDHPYNMTLRFRLLRQQGYNISSKSFERFRGKWESSYDKNVEELLSLYEASQLRMRGEEALDEAFRFATAQLEAIVQDPTTDPTVVGEVCQALKWPMYKNLPRLQASHYIGLYSEKPWRNESLPNFAKMDFSKLQKLHQKEIAYISKWWDDYGFAEKLSFARNRIVEGYFFALGIFFEPQLSTARLIMTKIIAIGSVLDDIYDVYGTFEELKLLTLALERWDKSETKKLPKYMKMYYEALLDVFEEIEQEMSQKETTPYCIHQMKEATKELGRVFLVEAKWCKEGYTPTVEEYLDIALISFGHKLLMVTALLGMGSTIATQQIVQWITSMPNILKASAIICRLMNDIVSHKFEQERGHVASAIECYMEQNYMSEHDVLIILGKQIDEFWKDMVENYCVVITEEEVPRGVLMRVLNLTRLFNVIYKDGDGYTQSHGSTKTHIKSLLVDSLPL
What is the function of this protein?
Sesquiterpene synthase producing exclusively alpha-farnesene.  Associated with the production of sesquiterpenes responsible for the aroma of the fruit.
What are the official names of this protein?
Alpha-farnesene synthase, CmTpsDul.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGPLF_DROME
Sequence: MPKTVVVTHPGKPINNEKRFRFELLYFCVILLMVVGLAAGYFMWMMSFSTHSPNKGLHILDRSEWLGEPPSGKYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTIQAFHMKSFGWVDIGYNFLVGGDGQIYVGRGWHIQGQHVNGYGAISVSIAFIGTFVNMEPPARQIEAAKRLMDEGVRLHRLQPDYHIYAHRQLSPTESPGQKLFELMQNWPRFTQDPTSLRLLSNETVKIVTRPYWLAQPPIVPLTPLKLPIESVRFVATNTPSCFTQAECTFRVRLLQNWHIESNGYKDINYNFVAAGDENIYEARGWDHSCEPPKDADELVVAFIGPSSSNKKIALELIKQGIKLGHISKNYSLIDDLEKS
What is the function of this protein?
Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response.
What are the official names of this protein?
Peptidoglycan-recognition protein LF, PGRP-like protein.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NRT27_ARATH
Sequence: MEPSQRNTKPPSFSDSTIPVDSDGRATVFRPFSLSSPHSRAFHLAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSFILVRFFVGFSLANFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTIAEFLPRAVAWRVSFVFPAIFQVTTAVLVLLYGQDTPHGNRKNSNQNKLTIPEEEEVLVVEEDERSSFVEILIGGLGNYRAWILALLYGYSYGVELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRFGMRGRLWGLWIVQSVAGLLCVLLGRVNSLWGSILVMWVFSVFVQAASGLVFGVVPFVSTRSLGVVAGITGSGGTVGAVVTQFLLFSGDDVRKQRSISLMGLMTFVFALSVTSIYFPQWGGMCCGPSSSSEEEDISRGLLVEDEDEEGKVVSGSLRPVC
What is the function of this protein?
Involved in high-affinity nitrate transport.  Controls nitrate content in seeds.
What are the official names of this protein?
High affinity nitrate transporter 2.7, AtNRT2:7.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: CTTB2_EULMM
Sequence: MATDGASCEPDASRAPEEAAGATAEAARKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCRKMQERMSTQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEEVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMKKMIEQLKRGSDSKPSLSLPRKTKDRRSVSISVGTEGPLTRSVACQTDLAVESTEHVKKSPLTVPVKPSPGSAKGSVGANAALVRPGIDRQASHGDLIGASLPTVPPASANRIEENGPSTGSPPDLTSSAAQSPAAAPHGLPPAHGSQSGSQSPCASAPPHSAPPHPGLNPRVQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPPVGAAPRPGASPTGDVGAHPPVGRTSLKTPGVARVDRGNPPPIPPKKPGLSQTPSPPHPQLKVIMDSSRASNAGAKVDNKTVASSPPSSLPQGNRVISEENLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAETPGLNQPACSGSSLVIPTTTAFRSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLNAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDAHINHAADGGQTPLYLACKNGNKECIKLLLEAGTDRSVKTRDGWTPVHAAVDTGNVDSLKLLMYHGAPAHGNSLNEEEPESDASDLDEGEESSEGKSKPVVPADLINHADREGWTAAHIAASKGFKNCLEILCRHRGLEPERRDKCNRTVHDVATDDCKHLLENLNALKIPLRISVGEIQPGNYGSNDFECENTICALHIRKQTSWDDFSKAVSQALTNHFQAISSDGWWSLEDTAFNNTADSDIGLSTSSVRAIMLGSVPWSAGQSLAQSPWDFMRKTKAEQVTVLLSGPQEGCLSSVTYTSMIPLQMLQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVSAEVDAGFSKEQLVDLFISSACLIPVKQSPVKKKIIIILENLEKSSLSELLGDFLAPLEIRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGPDLLVQQHFRWVQLRWDGEPMQGLLQRFLRRKLVNKFRGQMPSPCDPVCKTIAWALSVWRQLNSCLARLGTPEALLGPKYFLPCPVVPGHAQATVKWMSKLWNAVIAPRVQEAILSRASVKRQPGFGQTTTKKHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSLVSNYNSCSKKKESGAWRKVNTSPRRKSGRFSSPTWNKPDLSNEGIKNKTISQLNCNKNASLSKQKSLENDLSLMLNLDQSLSLGSDDEADLVRELQSMCSSKSESDISKIADSRDDLRTFDSSGNNPAFSATANNPRMPVSQKEVSPLSSHQTTECSNNKSKTEPGVSRVKSFLPVPRSKVTQCSQNTKRSSSSSNTRQIEINNNSKEENWNLHKNEHIEKLNK
What is the function of this protein?
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
What are the official names of this protein?
Cortactin-binding protein 2, CortBP2.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation.
Protein: FYB1_RAT
Sequence: MDGKTDVKSLMAKFNTGSNPTEEVSTSSRPFKVAGQNSPSGIQSKKNLFDNQGNASPPAGPSNMSKFGTTKPPLAAKPTYEEKSEKEPKPPFLKPTGVSPRFGTQPNSVSRDPEVKVGFLKPVSPKPTSLTKEDSKPVILRPPGNKLHNLNQESDLKTLGPKPGSTPPVPENDLKPGFSKIAGAKSKFMPAPQDADSKPRFPRHTYGQKPSLSTEDAQEEESIPKNTPVQKGSPVQLGAKSRGSPFKPAKEDPEDKDHGTPSSPFAGVVLKPAASRGSPGLSKNSEEKKEERKTDIPKNIFLNKLNQEEPARFPKAPSKLTAGTPWGQSQEKEGDKDSATPKQKPLPPLSVLGPPPSKPSRPPNVDLTRFRKADSANSSNKSQTPYSTTSLPPPPPTQPASQPPLPASHPAHLPAPSLPPRNIKPPLDLKHPINEENQDGVMHSDGTGNLEEEQESDGEMYEDIESSKERDKKREKEEKKRLELERKEQKEREKKEQELRKKFKLTGPIQVIHHAKACCDVKGGKNELSFKQGEDIEIIRITDNPEGKWLGRTARGSYGYIKTTAVKIDYDSLKRKKNTINAVPPRPVEEDQDVYDDVAEQDAPNSHSQSGSGGMFPPPPADDDIYDGIEEEDADDGSVPQVDEKTNAWSWGILKMLKGKDERKKSIREKPKVSESDSNEGSSFPSPHKQLDVGEEVYDDVDASDFPPPPAEMSQGMSVGKTKAEEKDPKKLKKQEKEEKDLRKKFKYDGEIRVLYSTKVASSLTSKKWGTRDLQIKPGESLEVIQSTDDTKVLCRNEEGKYGYVLRSYLVDNDGEIYDDIADGCIYDND
What is the function of this protein?
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity).  May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity).  Modulates the expression of IL2 (By similarity).  Involved in platelet activation (By similarity).  Prevents the degradation of SKAP1 and SKAP2 (By similarity).  May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493).
What are the official names of this protein?
FYN-binding protein 1, Adhesion and degranulation promoting adaptor protein, ADAP, FYB-120/130, p120/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell junction. Note=Colocalizes with TMEM47 at cell- cell contacts in podocytes.
Protein: SPCA_ARTOC
Sequence: MHLATGLAVALPFIGAASAQYFPPPVEGVTVVESKFDKNVKITYKENDICETTEGVRSFTGHVHLPPNNNDFGVNQNYSINTFFWFFEAREDPKNAPLSIWLNGGPGSSSMIGLFQENGPCMVNNDSNSTTNNPYSWNNKVNMLYIDQPNQVGFSYDVPTNVTVNPINDEVTVADFSNGVPEQNNTLLVGTLGSQNPYATANNTQNAARSIWHFAQVWFQEFPEYKPNNDKVSIWTESYGGRYGPAFTSYFQEQNEKIKNHTITEEGEMHILHLDTVGIINGCVDLMEQATSYPDFAYNNTYGIKAYNQSQYDSMINEFYRTGGCRDQLIHCRDVAAESDPHFYSHNETVNKICNDAGDFCGQKLEDAFESANLGFYDIAHPLNDPFPPQFYKGYLSQAHVLADMGMPVNFSQASDAVWKAFHTVGDYGRGDVRGYIDDLAYLLENGIKVALVYGDRDYICNWFGGEKVSLALNYTGTENFHKAGYTDVKVNSQVGGQVRQYGNFSFTRVYEAGHEVPAYQPEVSLEIFHRIMFNKDIATGEIDIAQKPDYSTTGTADTFHIKNDIPPEPEPTCYVLSMGRTCSEEQVKAVKDGTAVVENYIVKSPAGKKQGPPPTSTSPPSPTSSSEGSVKEFSVSVLGVSVLAAITFFL
What is the function of this protein?
Extracellular serine carboxypeptidase that contributes to pathogenicity.
What are the official names of this protein?
Carboxypeptidase S1 homolog A, Serine carboxypeptidase A, SPCA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: PDE3B_MOUSE
Sequence: MRKDERERDAPAMRSPPPPPASAASPPESLRNGYVKSCVSPLRQDPPRSFFFHLCRFCNVEPPAASLRAGARLSLGVLAAFVLAALLGARPERWAAAAAGLRTLLSACSLSLSPLFSIACAFFFLTCFLTRAQRGPGRGAGSWWLLALPACCYLGDFAAWQWWSWLRGEPAAAGRLCLVLSCVGLLTLAPRVRLRHGVLVLLFAGLVWWVSFSGLGALPPALRPLLSCLVGGAGCLLALGLDHFFHVRGASPPPRSASTAEEKVPVIRPRRRSSCVSLGESAAGYYGSGKMFRRPSLPCISREQMILWDWDLKQWCKPHYQNSGGGNGVDLSVLNEARNMVSDLLIDPSLPPQVISSLRSISSLMGAFSGSCRPKINSFTPFPGFYPCSEVEDPVEKGDRKLHKGLSGRTSFPTPQLRRSSGASSLLTNEHCSRWDRSSGKRSYQELSVSSHGCHLNGPFSSNLFTIPKQRSSSVSLTHHAGLRRAGALPSHSLLNSSSHVPVSAGSLTNRSPIGFPDTTDFLTKPNIILHRSLGSVSSAADFHQYLRNSDSNLCSSCGHQILKYVSTCEPDGTDHPSEKSGEEDSSVFSKEPLNIVETQEEETMKKACRELFLEGDSHLMEEAQQPNIDQEVSLDPMLVEDYDSLIEKMNNWNFQIFELVEKMGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENGYRDIPYHNRVHATDVLHAVWYLTTRPIPGLPQIHNNHETETKADSDGRLGSGQIAYISSKSCCIPDMSYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSSENDRLLVCQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEAALGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIETEEGDDTESDDDDDDDDGDGGEELDSDDEETEDNLNPKPQRRKGRRRIFCQLMHHLTENHKIWKEIIEEEEEKCKAEGNKLQVDNASLPQADEIQVIEEADEEEEQMFE
What is the function of this protein?
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:10454575).  Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (By similarity).  Controls cardiac contractility by reducing cAMP concentration in cardiocytes (PubMed:15294162).
What are the official names of this protein?
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B, CGIPDE1, Cyclic GMP-inhibited phosphodiesterase B, CGI-PDE B.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: ARPC3_DICDI
Sequence: MVYHSQFNDESAGFRLVGNVPILPLKTTHKGPAPKGDANSVDIIDEALDLFKANILFRNFEVQGNGDRVLIYLTLYITKCLLKIAPMNKADAEKALFLIAQEQFSIPGESAFPLGGLVTVPNTRDAADTLRQYFTQLRLELGVRLCQRVYAVDPSKANKWWICFSKRKFLNKAL
What is the function of this protein?
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the pointed end of the daughter actin filament.  The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis.  In concert with a group of other proteins, the Arp2/3 complex plays a general role in the rapid activation and adaptation of the actin system to its multiple functions.
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 3, Arp2/3 complex 21 kDa subunit, p21-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, cell cortex. Cell projection, pseudopodium.
Protein: RS7_STUS1
Sequence: MPRRRVAAKREILDDPKYGSLILAKFMNHVMESGKKAVAERIVYGALDKVKERKNGDPLEVFEKALDAIAPLVEVKSRRVGGATYQVPVEVRPSRRNALAMRWLVDAARKRGEKSMALRLAGELLDAFEGKGAAVKKREDVHRMAEANKAFSHYRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: LON_DICNV
Sequence: MTDKIYPILPLRDVVVFPHVIVPLFIGREKSIAALDAAMNGSQELLLVPQRDPAVVEPTLADLHEIGSLGRIVQMAKLSDGTVKALVEGLYRVHLEALNDDEKMFSAKKRNMLEKNSTKSEEHDSIVEILIEEFAKYLRNQERSADELLETLRGINDIGRISDTIAAHMDFRIEERVHLLAMEDAYERSQRLMILLAQESEKNELNKKIKNRVKQQMERNQREYYLNEKIKAIQKELGEMDEAQNDIELLEAQIKKAKMPVDVEKKALSELNKLKQMSAMSSEANVIRNYLEWLIDYPWAIEKPARYDLEEAARILDRDHYGLEDVKERILEYLAVQKRINEHNQKEAGTIGKGPIICLIGPPGVGKTSLGKSIAEATGRDFDRIALGGLHDEAEIRGHRRTYIGALPGKIVQKLCKLGSNNPVILLDEIDKIGHDHHGDPAAALLEVLDPAQNHTFNDHYLETDIDLSNVLFIATANTLNISEPLLDRMEVIRLPGYTTQEKIQIAKRYIVPRQRKENVLKASEFKIKNGVLNDVIEDYTREAGVRNLEREIGKLARKSVRRLQEGKQKSILITPNNLKDFLGVAKYHRNDEDLQAKIGSVTGLAWTSVGGELLQIEGVAFSGKGRLTHTGQLGDVMQESIRTALSVVRSYLDDLDDNFRFDEYDIHLHLPEGATPKDGPSAGIAMATALLSALSKQAVRGDLAMTGEITLHGKVLAIGGLKEKLLAAQRGRLKMVLIPEDNLKDLDEIPEEVKAALEIVPVSHIHEVFDHAFVADHAPFKARIEQKSLPTVSAVMHETPAGRC
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_CLOK5
Sequence: MDFGVQDIKNIIPHRYPFLLIDRVSYIEPGKKVVAYKNVTSNEYFFQGHFPEMPVMPGVLIIEALAQAGAVAILSQEEFKGKIAFFGAINKAKFRRNVVPGDTLKLEVEIIKIKGSAGIGKGTAYIGEKKAAEGELMFMIGDKN
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_THEVO
Sequence: MAKDYYKILGVDRNASEEDIKKAFRELAKKWHPDLHPDNKAEAEEKFKEISEAYEVLSDPEKRRIYDQTGSVDFGGGGSNFNWDNFTHFSDINDIFNEIFGGNFGSDFFSGFGNRQSTRNIDLDMYTNLDISLEEAYYGTEKRIKFRRNAICPDCKGTGAKNGKLITCPTCHGTGQQRVVRGQGFFRMVTVTTCNTCGGKGRIPEEKCPRCNGTGTIVVDEDITVKIPRGATDNLRLRVSGKGQSYDGRTGDLYVILRIKQDKNLQRINDDLLLDQKINFGQAALGADIPIQIFNEKYNLKIPEGTQPGDVIKIKGAGMPHLNGHGSGDLLVRINVEVPKRLTAKQRELIRELFDIKENHKSWFH
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNE_IDILO
Sequence: MLTPDNKLMSETETAWERYKEVVESITLTAEQEQILRALFAVSPFIGRVAESYPEHLVTDFFDGSGSSVRLIDADSYGDRIAESLSQVTNEDEAKKCLRRLRHCWMAKLAAADILQQVSLKESLHHYSTFADAAINKSLEWLFERFVQRHGKPLDANDQLMPMLVIGMGKLGGKELNFSSDIDLIFAFPEQGETQGPGRNLEHGVFYKRLAQSLIGLLDETTADGQVFRVDMRLRPFGQSGPLVTSLNALEHYYQEQGRDWERYAMVKARMIGADEQYEQAFQQLIRPFVYRRYIDFGAIEALRKMKLLITQETRRQGVKNNIKLGAGGIREVEFIVQAHQLIRGGQEKSLQTRSVYIAMNGLVELDLIDPEHARQLLKDYEYLRVIEHRLQQIDDQQTQQLPTDETGRMRLCAMLNEPEWETLQRKIDECMERIHAEFQQVVGAESEDDEDEQGLQVLWQDMLDDDAALEIIESEGVDEPQALWTLIKNFRQESRRRSSGPRGRSALARLMPIMLRHAIQHQHPERLLERLLSIIKAVMSRTAYIELLAENPGAREQLCKLCMASPWISEQLALHPILLDELIDPQQLYSLPESKDYAAVLREYLMRIPEQDLETQMDALRQAKQALQLKIAAADISGVLELMNVSDHLSALAEAIISEVVGLAWQHLTQKHGKPAGTCLDNTGFAVLGYGKLGGQELGYGSDLDLVFVTDANYQGQTDGQRPIEVQQFYLRLAQRILHLFTTRTVAGILYDVDLRLRPSGQAGLLVTQVNSFARYLRDDAWTWELQALVRARPVYGVPALRDTVMDIRRSVLSQKRDEQELRQSIVKMREKMREHLTQRNSRKFDLKQDPGGIADIEFITQYLVLRYAHKYPELCKYSDNVRLLTEAQQLHLLTEVDAQNLINAFQIFRCESHSLALQGEQLLEEHNLDNERQAVLNCWNHLLEDD
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: YIHY_SALPB
Sequence: MLKTVHQKAGRHTRPVRAWLKLLWQRIDEDNMTTLAGNLAYVSLLSLVPLIAVVFALFAAFPMFSDVSIQLRHFIFANFMPATGDVIQRYIEQFVANSNKMTAVGACGLIVTALLLMYAIDSALNTIWRSKRTRPKVYSFAVYWMILTLGPLLAGASLAISSYLLSLRWASDLNTVIDNVLRILPLLLSWISFWLLYSIVPTTRVPNRDALVGAFVAALLFESGKKGFALYITMFPSYQLIYGVLAVIPILFVWVYWTWCIVLLGAEITVTLGEYRKLKQAAEQEEADQP
What are the official names of this protein?
UPF0761 membrane protein YihY.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y2923_MYCTU
Sequence: MTQLWVERTGTRRYIGRSTRGAQVLVGSEDVDGVFTPGELLKIALAACSGMASDQPLARRLGDDYQAVVKVSGAADRDQERYPLIEETMELDLSGLTEDEKERLLVVINRAVELACTVGRTLKSGTTVNLEVVDVGA
What are the official names of this protein?
Uncharacterized protein Rv2923c.
Protein: RS4_STRPG
Sequence: MSRYTGPSWKQSRRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFSYGLGEKQFRNLFVQATKIKEGTLGFNFMVLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVDPGQVISVREKSMKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.