PharMolix/UniProtQA huggingface dataset:
Protein: TRMD_BIFLD
Sequence: MKIDIVSVFPEYFEVMNLSLMGKAQAKGLLEIKAHNLRDWTHDVHHSVDDTPVGGGAGMVMKPEVWSECLDELLGFSQPSAATDAVDTSDPGDSAAPDSSAPSGAPVLIFPNPSAPLFTQRDATELSHADHLLFGCGRYEGYDARIPDYYRAQGVDVREYSIGDYVLNGGEVAVSVMLEAITRLMPGFMGNPDSIVEESYTGEGALLEHRQYTKPAVWRGIAVPDVLLSGDHGKVDRFRRDEALARTAEIRPDLIAALDCKALDKADRKTLMALGWEVSAAHPRRLAD
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RH5_ORYSJ
Sequence: MGRSMLPEQQEDVSRKSKKEKKSKKDKKRKLEAEAEVVVVEAAAATSTDEATKSSKKKRAKGDLGQGEEAENGGGKVVAVTGKGSADAKYAPLSSFAATALPPQVLDCCKGFERPSPIQAYAWPYLLDGRDFIGIAATGSGKTIAFGVPALMHVRRKMGEKSAKKGVPRVLVLSPTRELAQQIADVLCEAGAPCGISSVCLYGGTSKGPQISALKSGVDIVIGTPGRMKDLIEMGICRLNDVSFVVLDEADRMLDMGFEPEVRAILSQTASVRQTVMFSATWPPAVHQLAQEFMDPNPIKVVIGSEDLAANHDVMQIVEVLDDRSRDSRLVALLDKYHKAQRNRVLVFVLYKREATRVETMLQRRGWSAVSVHGDKAQHDRTKALSLFKEGSCPLMIATDVASRGLDIPDVEVVINYSYPLTTEDYVHRIGRTGRAGKKGVAHTFFTQENKGLAGELVNVLREAGQVVPPALTKFGTHVKKKESQIYGSHFKEIKADAPKSTKITFGDSDED
What is the function of this protein?
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis.  Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ACDH2_FRASN
Sequence: MQQVAIIGSGNIGTDLLIKIKRRSESLSVAAMVGIDPESDGLARARRLGVATTSDGVAGLLAMPEFEQAGIVLDATSANAHRANAAALAPYGRRLIDLTPAALGPFVVPAVNLDEHLSAPNVNMTTCGGQATVPIVAAISRVTPVAYAEIVATVASKSAGPGTRANIDEFTETTAHALESVGGARRGKAIIILNPAEPPLIMRDTVLCLVGDVDRDAVTESIHRMIADVAAYVPGYRLKQDVQFTPVDPAEMRILLPDDTVDVRWKVSVFLEVEGAAHYLPAYAGNLDIMTSAAVRVAERIAGAEVTA
What are the official names of this protein?
Acetaldehyde dehydrogenase 2, Acetaldehyde dehydrogenase [acetylating] 2.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: DCD_FRATN
Sequence: MTIKSDKWIKKMSQEHNMIEPFEAGQVKVINNQKIVSYGTSSYGYDVRCADEFKIFTNINSSIVDPKNFNDKNFVDFKGDVCIIPPNSFALARTVEKFKIPRDTLVVCLGKSTYARCGIIVNVTPLEPEWEGYVTLEFSNTTPLPAKIYANEGVAQMLFFQSDEECETSYADKGGKYQGQVGVTLPKC
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: AGUA_ASPFC
Sequence: MWSGIPIFALLSSIGIAAAETGLDGWLRYASVPCNGNCQRALPSHIVTLNSTRSSPVYVAGQELQDGLHQILGKHASVKSTGCSTDSSIIVGTVEAYRQVCNAGRQVPQLDVDGFWLSIREKSVLIVGQSERGALYGAYEYLSMLAQGNFSQVSYATSPHAPIRWVNQWDNMDGSIERGYGGPSIFFKDGVIRQDLSRVQQYARLLASVRINGIIVNNVNANASLLMPSNMDGLARIADIFRPYGIRVGISLNFASPSTLGNLSTYDPFDSSVIAWWGNVTDQLYARIPDMAGYLVKANSEGQPGPTTYNRTLADGANMFARALKPYGGVVMFRAFVYDHHISEDNWYNDRANAAVDFFKPLDGKFDDNVVVQIKYGPIDFQVREPASPLFANLYKTNTAIELQVTQEYLGQQSHLVYLPPLWQTILGFDLRVDQKPSLVRDIISGQRFDRPLGGWAAVVNVGTNSTWLGSHLAMSNLYAYGRLAWEPTLDSEDIVQDWIRLTFGLDRRIVDTLTQMSMESWPAYENYSGNLGIQTLTDILYTHYGPNPASQDGNGWGQWTRADHLSIGMDRTVKNGTKFSGQYPAEVAAMYENIETTPDNLLLWFHHVNYTQRLHSGKTVIQHFYDAHYTGAETAQTFVSQWESLRERIDAERYQHVLTRLIYQAGHSIVWRDAINNFYHNLSGIADEKQRVGHHPWRVEAEDMQLDGYVPYAVSPFETASNYTAIVTASNGTTGTASATLDFKTGTYDLGINYYDMYGGKSHWTVYLNDRVVGQWQGNSEDVLSHTPSIYLDGHSATRITFRDVKIHKGDRLKIVGKPDGVEPAPLDYVVVLPPGIVD
What is the function of this protein?
Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.  Releases 4-O-methylglucuronic acid from xylan (By similarity).
What are the official names of this protein?
Probable alpha-glucuronidase A, Alpha-glucosiduronase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 67 family.
What are the subcellular locations of this protein?
Secreted.
Protein: EMRB_ACIBT
Sequence: MNKHVEAEWRFPAKTAWAIFAAMIFGNFMAILDIQIVASSLNEVQAGMSASRYEVTWVQTVYLIAEIIAIPMSSIVSRVLSTRVYYTMCAIGFTVSSLLCALSWNLESLLVFRGIQGFMGGGMIPTSMTALYLLFPEPKRSLPLVMFGMISTLGPAIGPTIGGWLTNNFSWHWMFLINIIPGIIIATVIYSGPNIDRANYSLIKSMDWFSLVGMAMFLGGLEYFLDEGARHDWLADTGVRIAFMVCVVGGMIFFSRSFTQPKPLLDLSVFKNKNFTLSAITTFVIGMALYGLGYMIPVFLGQVREMNSSQIGHVMMVTGIVMFCFAPFLAWLIPNFDTRKTVFVGMILAGFGVWLNSHLSIHSDYDFMFWPQIYRGIGLMICLIVVSHLAMSTLPLSKVADASGIYNLMRNIGGAVGLALINSSLDWLTAMHVTQINQSMTPQNWIFTERLDQLTAQYQEVGTNAQQIALSVIYRDIHFQALTSSFNDLLRMLAIIMFVTAFLTIFMDRGKK
What is the function of this protein?
Probably part of an efflux pump system that contributes to adaptation to osmotic stress and resistance to colistin.
What are the official names of this protein?
Colistin resistance protein EmrB.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EmrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: METK_FINM2
Sequence: MKNIFLTSESVTEGHPDKVCDQISDAILDAIIKEDKDARVACETCSTTGLVMVMGEITTTSYVDIRSIVRKTLAEIGYDNADYGIDARTCAIITSLEEQSKDIAQGVDESEEYKDNKSDEYDRYGAGDQGMVFGYATNETESGLPLPLELSHKLARRLATVRKEKILNYLRPDGKTQVTVEYENDAPKRIEAIVVSTQHDPDVDYEQLKEDIKREVILKIVDESMIDENTKFFINPTGKFVIGGPMGDAGLTGRKIIVDTYGGFCNHGGGAFSGKDPTKTDRSAAYFARYIAKNVVAAGLCDKCEVGFSYAIGVAKPISMFINTFGTNKIEEEKIIQAINENFDARPKAIIDKLDLQRPIYREVASYGHFGRNDLDLSWEKCDKAEALKKYL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_ECO5E
Sequence: MSNRKYFGTDGIRGRVGDAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSALFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDAVEEAIEAEMEKEISCVDSAELGKASRIVDAAGRYIEFCKATFPNELSLSELKIVVDCANGATYHIAPNVLRELGANVIAIGCEPNGVNINAEVGATDVRALQARVLAEKADLGIAFDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMARNHMSLHDLCSGMKMFPQILVNVRYTAGSGDPLEHESVKAVTAEVETALGSRGRVLLRKSGTEPLIRVMVEGEDEAQVTEFAHRIADAVKAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: BDEF_RUDPH
Sequence: AVPDVAFNAYG
What is the function of this protein?
Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro.  Has antibacterial activity against S. aureus (MIC=9. 6 mg/L), B. subtilis (MIC=76. 8 mg/L), M. tetragenus (MIC=38. 4 mg/L), E. coli (MIC=76. 8 mg/L), V. parahaemolyticus (MIC=19. 2 mg/L), and V. anguillarum (MIC=2. 1 mg/L).
What are the official names of this protein?
Big defensin, RPD-1.
What is the protein family that this protein belongs to?
Belongs to the big defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PTSN_ECOLI
Sequence: MTNNDTTLQLSSVLNRECTRSRVHCQSKKRALEIISELAAKQLSLPPQVVFEAILTREKMGSTGIGNGIAIPHGKLEEDTLRAVGVFVQLETPIAFDAIDNQPVDLLFALLVPADQTKTHLHTLSLVAKRLADKTICRRLRAAQSDEELYQIITDTEGTPDEA
What is the function of this protein?
Seems to have a role in regulating nitrogen assimilation.
What are the official names of this protein?
Nitrogen regulatory protein, Enzyme IIA-NTR, PTS system EIIA component, Phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_THESQ
Sequence: MKIHFVGIGGIGMSAVALHEFLNGNDVYGSNIEETERTAYLRKLGIPIFVPHSADNWYDPDLVIKTPAVRDDNPEIVRARMERVPIENRLHYFRDILKREKKEEFAVTGTDGKTTTTAMVAHVLKHLKKSPTVFLGGIMDSLEHGNYEKGNGPVVYELDESEEFFSEFSPNYLIITNARGDHLENYGNSLSRYRSAFEKISRNTDLVVTFAEDELTSHLGDVTFGVKKGTYTLEMRSASRAEQKAVVEKNGKRYLELKLKVPGFHNVLNALAVIALFDSLGYDLAPVLEALEEFRGVHRRFSIAFHDPETNIYVIDDYAHTPDEIRNLLQTAKEVFENEKIVVIFQPHRYSRLEREDGNFAKALQLADEVVVTEVYDAFEEKKNGVSGKMIWDSLKSLGKEAYFVEKLPELEKVIPVSENTVFLFVGAGDIIYSSRRFVERYQSSKSSPSRVLGSNK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GANB_BACSU
Sequence: MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVKKVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHPYDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLSFEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRAVRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSVLKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVMEAVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKWYGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR
What is the function of this protein?
Involved in galactan degradation (PubMed:17056685, PubMed:27501980).  Degrades arabinose-free galactan to galactooligosaccharides, producing galactotetraose as the main product along with galactotriose, galactobiose, and galactose (PubMed:27501980).  Is also able to degrade galactotetraose, galactotriose and galactobiose, suggesting an additional exo-mode of activity (PubMed:27501980).  May hydrolyze the beta-1,4-galactan linkages of the galactan portion of arabinogalactan type I, a pectic plant polysaccharide from which most of the arabinose has been removed (Probable).
What are the official names of this protein?
Endo-beta-1,4-galactanase, Galactanase, Arabinogalactan endo-beta-1,4-galactanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 53 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYW_CHLMU
Sequence: MNKKRVLTGDRPTGKLHLGHWIGSIMNRLQLQNDPRYDCFFIIADLHTLTTKTRKEEVLHIDSHIYDVLADWLSVGIDPEKSAIYLQSAIPEIYELNLLFSMLTPLNHIMGIPSIKEMARNASINEESLSHGLIGYPVLQSADILLAKAHLVPVGKDNEAHVELTRDIAKTFNRLYGSVFPEPDILQGELTSLVGTNGQGKMSKSANNAIYLSDDEKTVQEKIRKMYTDPNRVHATTPGRVEGNPLFIYHDLFNPHKEEVEEFKTRYRQGCIKDVEVKARLAEEINLFLNPFREKRSEFVAQPKILEEALQKGTEKMRSVARETMEEVHNNLGLSRKWRSILASSK
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACRB_ASPFC
Sequence: MPRSSATARKSHSNRHENGSANTGKKVAKQKSNGHLNGNLNGGSASSSLSSSQVDLPSSRSSSDPVVPTTTAASTKLNGTPDSSKGDCNAPDHLNGYAKGNADMSYVQNDGVASQTGGDVAGPASRRTEKSATGSKRSPSNASVNPLQLASTILKSCPMYDTIAILIFLLQLPPMVLTLVQFLFASLTFLPPSGASAGSLTSNFDIFQGPAGTPSLGTMIAMDGFCLLIWGLFMWTWAQNFALDLAHVQVAITLGGGGFGKNGGVNTLCVGIVLIMHLVRSKGIQDFVIGHLLSSNIISPDMLSQYSHLLPTEFRRTEPQTSPSWLRSLLAVHILAQAGTAMARRSMAKNRTPNPPRTGKRIDTEASAGSQTQIDSAFESGASVSSYIGADGQIVTSAAHKDGRDRLLSAKKRRRQANQVRSRQPFWAALASTKITVMREYEHSRALSKTARSLPMTEDDLQGLSLDDGLVWITEIDSSTIKFAAGDFSSADDSSGSGACEAGCLGSEDMEPFYVCVNGALWATATICKVHDAPKGSSMVHWRGEISGLAPNCAYTCSFVRSDTDEEICVISVKTPANNDAEQVSSVSTPPHPSYRPSSPTTTLKNSIVNAEAKLNEKRSRLRKAKNDHKLIISKIRKELDNYNHRLHSGTDENRQKQRSLQLERNIRQTEEATALLEDQLDNLENVPEEELRKWSDQKAKYEHELGLLNSAKEELASARSAIAREVSSLETELSSAIQRRERLQSRRTRINEQYERIVSANAQGLNERERRAAEQFAREQDQAKLEATFNEQFATIGQSVQEYQLRAQQIWQQCDAIEQAIQQQHQQMLLDPGPLTPEGNLPGTNPFSESALPLGALTSTAPSSRSLLGLSFPPLKSSPLQTASSPVGASSSHPTSPVQQPSYLNFPTSPLVNASSHLDSDFVYRHRSFSNRSARSSLYGSDFMDSSRRQPFQLDLSELLADKRSPGSDSNTALNSGLRPVSSPFQRAGSRGSGSGSNGSGGSGSGSGSPSSVYGKTN
What is the function of this protein?
Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  Involved in resistance to acriflavine, and required for normal growth on a range of sole carbon sources, including fructose, cellobiose, raffinose, and starch, and reduced utilization of amino acids, including GABA and beta-alanine, as sole carbon and nitrogen sources (By similarity).
What are the official names of this protein?
Probable ubiquitination network signaling protein acrB, Acriflavine resistance protein B.
What is the protein family that this protein belongs to?
Belongs to the acrB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GYP7_YARLI
Sequence: MNSLWPVSVSHTQLTSINHQVYVHPTPSSKDNIPGFLALAKPRGATTDKEILVAWIPESKLQESAADFESYVKVDIKESGTPASSSLNLAETLVSPPPSSSFSSYAFSIPISDIFSLQVKQPSLGWWWGSITIHTRSKEDQLPPLYFHDAESQSTIMEQKRRNKKFETFDSESGSSMFWGGDHFIQVLSKYANLERAESDHSFLLVNPREGDAERFGTNLTGGSEEPSQLVAGIPGRGAGGDPVDRGAQVQKAFSDIRWGLLSNLAKVTQLTRKVSQGVWDSSPQPVKQLLMKPEVKKIGDDFDSARIYLAKWALSVAEESQRAKLKVLFDDELRELVSDEGFELIDAENNPQRRNEVSLAEWNAFFDYNGRLIVTVNEVKERIFHGGLAPAVRPEGWLFLLGVYPWDSTAAERKELVSKLRVDYNRLKKEWWVQEDKERDDFWRDQLSRIEKDVHRTDRNITFFAECDAKKDGDDDNYDKDEFGFSSQINSNIHLIQLRDMLITYNQHNKNLGYVQGMSDLLSPLYVVLQDDTLAFWAFSAFMERMERNYLRDQSGMRNQLLCLDHLVQFMLPSLYKHLEKTESTNLFFFFRMLLVWFKRELLWDDVLRLWEVLWTDYLSSQFVLFVCLAILDKHKDVMIDHLAGFDEILKYMNELSMTIDLDELLVRAELLFYRFRRTVELIDRKNEDRRNSADGSEPVSITEDLRELLSRKVIVVREGERPEGVMGG
What is the function of this protein?
Most effectively accelerate the intrinsic GTPase activity of YPT7.  It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1.  YPT6 and SEC4 (By similarity).
What are the official names of this protein?
GTPase-activating protein GYP7, GAP for YPT7.
Protein: DEP6_FUSLA
Sequence: MIRQFSAGSSFTARHACEICRQRKVRCDRALPRCRRCERLNQACVYSPISQRRTRDEQLQELQERLAKTEAQLALDAPRGPASSMSSQSRSDSAAPAASRVPSVSASVPNSAATNPMDMVGTRSSNTSMDLPVNTSPMLDIDLFTAGADSNMALDWNPYLTALEPLDNLLPNRLSPRSLPQNGREEDISLAELNALHNYYFESVYFSFPFLNRDRFAGESTGNGPAINALIYSVALAGCTHSSPQHTKVSIYYTLARNYAEKCERDGQLNDLNFLQALLFIGRFEAMEGKVESSWMTLGRAAMLARLLRLPQMDRLEESTESQDGSGLSLLETTDPALLEERRRTFWALYILQSYIKTRTGWQCMLGDIKTFQINLPSPGLLRSDLTPLKMPFISEIGTEPCPEVSSYAGCVLMVDLALRCLDHAQGHGATNFWDGYCALVKNTDELFGMLKQHLNATSIRKDPVAFSLYLNLRATEIFSHESAIARSKEQGLPPLMTAESQRRATAAAFQISTAVRLNLPSPWKVDSDIIMLQAIFIAWPLAMALKAFYRELEHGGSRDSVNGVVTSSRLLFAALGHIEESGGHWHQSVAHVEAKLQELDEKNGFNSLAL
What is the function of this protein?
Transcription factor that positively regulates the expression of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099, PubMed:28460114).
What are the official names of this protein?
Depudecin biosynthesis cluster-specific transcription activator DEP6, Depudecin biosynthesis cluster protein 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: B2L10_MOUSE
Sequence: MADSQDPLHERTRRLLSDYIFFCAREPDTPEPPPTSVEAALLRSVTRQIQQEHQEFFSSFCESRGNRLELVKQMADKLLSKDQDFSWSQLVMLLAFAGTLMNQGPYMAVKQKRDLGNRVIVTRDCCLIVNFLYNLLMGRRHRARLEALGGWDGFCRFFKNPLPLGFWRRLLIQAFLSGFFATAIFFIWKRL
What is the function of this protein?
Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (By similarity).  Increases binding of AHCYL1/IRBIT to ITPR1 (By similarity).  Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (By similarity).  Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity).  Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (PubMed:27753540).
What are the official names of this protein?
Bcl-2-like protein 10, Bcl2-L-10, Anti-apoptotic protein Boo, Apoptosis regulator Bcl-B, Bcl-2 homolog Diva.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus membrane. Endoplasmic reticulum. Cytoplasm, cytoskeleton, spindle. Note=Localizes to mitochondria- associated endoplasmic reticulum membranes (MAMs) (By similarity). Localization to MAMs is greatly reduced under apoptotic stress conditions (By similarity).
Protein: RLMH_TERTT
Sequence: MKISILAVGGKMPAWVQEGYAEYAKRLPREIEPRMVELALANRSKSYSVDAVKQAEGEQILGAYDNAPGHKRLICLDVLGKSLRTEMLAEKMAAWQMDGVNPCLVIGGPDGLSQSCLQRADEKWSLSGLTMPHPLVRVLLIEQLYRAWTILQNHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_AGRFC
Sequence: MRKLDTRTIVVASHNKGKIAEIADLIGPFGFSAKSAAELNFSEPEETGTTFEENAAIKALASAKASGLPALSDDSGLVIDALDGAPGVYTANWAETADGTRDFAMAMQKVEDALAERGASKPEDRTARFVSVLCLAWPDGHVEYFRGEVEGTVVWPPRGTSGFGYDPIFKPDGYDTTFGEMSADEKHGWKHGDAFALSHRARAFKKFVETCLEA
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: ROK1_VANPO
Sequence: MDIFRLLTRGASVKKDPKNKNIGDAVENAKASNIEKNDKIAAENQITKELDFFHNKRIINKVNYNKAKETHAEDKEDKDNDNEEDEIKEEESLQYQKPLITNDEEAKLLRKSNKSNVSGEDIPLPIGSFEDLITRFSFDKRLLNNLILNHFTEPTPIQCEAIPLALNNRDMLACAPTGSGKTLAFLIPLIQQVINDKDTQGLKGLIISPTKELANQIFLECIKLSNRIFLDKKRPLQVALLSKSLSAKLRNKVISDKKYDIIVSTPLRLIDVVKNEALDLSQVKHLIFDEADKLFDKTFVEQSDDILSSCSHSSLRKSMFSATIPSNVEEIAKSIMMDPVRVIIGHKEAANTSIEQKLVFCGNEEGKLIAIKQLVQEGEFKPPVIIFLESITRAKALYHEMMYDSLNVDVIHAERTQVQRNKIIERFKSGDLWCLITTDVLARGVDFKGVNLVINYDVPRTAQAYVHRIGRTGRGGRSGKAVTFYTKEDSIAIKPIINVMKQSGSEISEWMEKVSKMTKKEKELVKKGRAHSERKQISTVPKIDKIKRKRKLEMIQASKKRKAIETKETE
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase ROK1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RECJ_THET8
Sequence: MRDRVRWRVLSLPPLAQWREVMAALEVGPEAALAYWHRGFRRKEDLDPPLALLPLKGLREAAALLEEALRQGKRIRVHGDYDADGLTGTAILVRGLAALGADVHPFIPHRLEEGYGVLMERVPEHLEASDLFLTVDCGITNHAELRELLENGVEVIVTDHHTPGKTPPPGLVVHPALTPDLKEKPTGAGVAFLLLWALHERLGLPPPLEYADLAAVGTIADVAPLWGWNRALVKEGLARIPASSWVGLRLLAEAVGYTGKAVEVAFRIAPRINAASRLGEAEKALRLLLTDDAAEAQALVGELHRLNARRQTLEEAMLRKLLPQADPEAKAIVLLDPEGHPGVMGIVASRILEATLRPVFLVAQGKGTVRSLAPISAVEALRSAEDLLLRYGGHKEAAGFAMDEALFPAFKARVEAYAARFPDPVREVALLDLLPEPGLLPQVFRELALLEPYGEGNPEPLFLLFGAPEEARRLGEGRHLAFRLKGVRVLAWKQGDLALPPEVEVAGLLSENAWNGHLAYEVQAVDLRKPEALEGGIAPFAYPLPLLEALARARLGEGVYVPEDNPEGLDYAWKAGFRLLPPEEAGLWLGLPPRPVLGRRVEVALGREARARLSAPPVLHTPEARLKALVHRRLLFAYERRHPGLFSEALLAYWEVNRVQEPAGSP
What is the function of this protein?
Single-stranded-DNA-specific exonuclease acting in a 5' to 3' direction; has no detectable activity on ssRNA.
What are the official names of this protein?
Single-stranded-DNA-specific exonuclease RecJ.
What is the protein family that this protein belongs to?
Belongs to the RecJ family.
Protein: RL5_MYCTU
Sequence: MTTAQKVQPRLKERYRSEIRDALRKQFGYGNVMQIPTVTKVVVNMGVGEAARDAKLINGAVNDLALITGQKPEVRRARKSIAQFKLREGMPVGVRVTLRGDRMWEFLDRLTSIALPRIRDFRGLSPKQFDGVGNYTFGLAEQAVFHEVDVDKIDRVRGMDINVVTSAATDDEGRALLRALGFPFKEN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: SLY1_ORYSJ
Sequence: MALTLRKKQLDSIVRMLHLNQQLQGSPDGVGGGVGSAEEEEAYKILVMDSPCVALLAPVLRVGELRRHGVTLHLNIDKARQQVPDAPAVYLLRPTAANVDRVAADAAAGLYASFHLNFSTCVPRALLERLASATAASRSAHRVARVADQYLDFVCLEEGLFSLAQPRAYVALNDPAAAEADITALVDAIALGLFCVVATLGAVPVIRCAGGGPAEMVAAALDARLRDHLIAKPNLFTEAASTAVASFQRPLLCLFDRNFELSVGIQHDWSYRPLVHDVLGLKSNKLKLPEKYDLDDTDPFWVANSWLQFPKVAEEIEAQLAKYKQDVDEVNQRTGGGRDGVEFDGTDLIGNTRHLMNAVNSLPELTERKKMIDKHTNIATALLGHIKGRSLDGYFECENSMLVDGTLDRTKLMNLLRGNGTKEDKLRLAVTYLLSFETPVPSDLEQVEAALRESEVDMSAFQYVKRIKSLNSQFAGASNTASKVNIVDWAEKLYGHSISAMTGVRNLLSDGKQLAATRAVEALMEGKPNPEVDNYLLFDPRAPKSGTAGQFRGPFREAIVFMIGGGNYIEYRSLTELTQRSQTTKQVIYGATEILNGVEFIQQLSELGQKAGLGGVSSSLPPQ
What is the function of this protein?
May be involved in the early secretory pathway.
What are the official names of this protein?
SEC1 family transport protein SLY1.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
Protein: YIDD_STRA1
Sequence: MLKSFLIFLVRFYQKNISPAFPASCRYRPTCSTYMIEAIQKHGLKGVLMGIARILRCHPLAHGGNDPVPDHFSLRRNKTDISD
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SSAA_STAAE
Sequence: MKKIVTATIATAGLATIAFAGHDAQAAEQNNNGYNSNDAQSYSYTYTIDAQGNYHYTWTGNWNPSQLTQNNTYYYNNYNTYSYNNASYNNYYNHSYQYNNYTNNSQTATNNYYTGGSGASYSTTSNNVHVTTTAAPSSNGRSISNGYASGSNLYTSGQCTYYVFDRVGGKIGSTWGNASNWANAAASSGYTVNNTPKVGAIMQTTQGYYGHVAYVEGVNSNGSVRVSEMNYGHGAGVVTSRTISANQAGSYNFIH
What is the function of this protein?
Not known; immunogenic protein.
What are the official names of this protein?
Staphylococcal secretory antigen SsaA.
What are the subcellular locations of this protein?
Secreted.