PharMolix/UniProtQA huggingface dataset:
Protein: IAGB_SALTY
Sequence: MHYFFIIVIWLLSINTAWADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHMKRLKKMGISEKQLLQDPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKRSDIRKRYAKKIWENYRKLKGMSAEEKNKRLSIAANK
What are the official names of this protein?
Invasion protein IagB.
What is the protein family that this protein belongs to?
Belongs to the IagB/IpgF/P19 family.
Protein: HIS3_LEIXX
Sequence: MTGLDEALTRIRFTDTGLVPAIVQQWYTRDVLMMGWMDAEAFRRTMTEGRVTFWSRSRQEYWRKGDSSGNIQFVRGVALDCDGDTLLVTVDQVGAACHTGTYTCFDADPLAPVLGERPESAADGW
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1758_MYCBO
Sequence: MARTDDDNWDLTSSVGVTATIVAVGRALATKDPRGLINDPFAEPLVRAVGLDLFTKMMDGELDMSTIADVSPAVAQAMVYGNAVRTKYFDDYLLNATAGGIRQVAILASGLDSRAYRLPWPTRTVVYEIDQPKVMEFKTTTLADLGAEPSAIRRAVPIDLRADWPTALQAAGFDSAAPTAWLAEGLLIYLKPQTQDRLFDNITALSAPGSMVATEFVTGIADFSAERARTISNPFRCHGVDVDLASLVYTGPRNHVLDYLAAKGWQPEGVSLAELFRRSGLDVRAADDDTIFISGCLTDHSSISPPTAAGWR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mb1758c.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: HUTH_CAUSK
Sequence: MIEVVLNPGEVSLSDWKAVYRGAPARLNESAGPVIAQSAAAVERILAKGAPVYGINTGFGKLASVRIGDADLETLQRNIVLSHAAGTGAPSPVAVIRLMMALKLASLAQGASGVRPATTDLLEAMIVKGLTPVVPCQGSVGASGDLAPLAHMAATMIGVGEIFVEGQRLPAVQALMEAGLKPLTLGPKEGLALLNGTQFSTANALAALFDAERLFQSALVTGALATEAAKGSDTPFDPRIHTLRRQPGQIETAAALRALMAGSAIRDSHREGDTRVQDPYCLRCQPQVMGAALDILRQAAVTLSTEANGVSDNPLIFPDTDEALSGGNFHAEPVAFAADIIALAVCEIGSIAERRIAMLVDPACSGLPAFLTPKPGLNSGFMIPQVTAAALVSENKQKAYPASVDSIPTSANQEDHVSMAAHGARRLLAMVEAAEAVIGIELLAAVQGCDFHAPLASSPALESVRGLLRAQVPHLSDDRHFHPDMEAANALVRSGAVVAAASSVELPGVEG
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y5469_VIBVU
Sequence: MELKIDTHSHTYASGHAYSTLIENARSAKENGLAMFCTTDHAESMPGAPHYWFFANQRVLPRFLEGVAILRGVEANILNTEGEIDLPLSVDPNLDWAIASFHEPVFAPSNKEAHTQALLNVIQGGRIDALGHLGNPHFDFDFHAVLHCAKDHNVAIEINNSTLKGHSRVGSVERCYEIARVGKALGVYFTTGSDAHFCQDVGKLDLASELLDSVGIDSHRVITHSPSQFLDFLELRGRGPIDELASLRQ
What are the official names of this protein?
Probable phosphatase VV2_1469.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: FAS_MOUSE
Sequence: MEEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGLYGLPKRSGKLKDLSKFDASFFGVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRGTNTGVWVGVSGSEASEALSRDPETLLGYSMVGCQRAMMANRLSFFFDFKGPSIALDTACSSSLLALQNAYQAIRSGECPAALVGGINLLLKPNTSVQFMKLGMLSPDGTCRSFDDSGSGYCRSEAVVAVLLTKKSLARRVYATILNAGTNTDGSKEQGVTFPSGEVQEQLICSLYQPAGLAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQAPLLIGSTKSNMGHPEPASGLAALTKVLLSLEHGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGNVGINSFGFGGSNVHVILQPNTRQAPAPTAHAALPHLLHASGRTLEAVQDLLEQGRQHSQDLAFVSMLNDIAATPTAAMPFRGYTVLGVEGRVQEVQQVSTNKRPLWFICSGMGTQWRGMGLSLMRLDSFRESILRSDEAVKPLGVKVSDLLLSTDERTFDDIVHAFVSLTAIQIALIDLLTSVGLKPDGIIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDAHLPPGSMAAVGLSWEECKQRCPAGVVPACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAFHSYFMEGIAPTLLQALKKVIREPRPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLVSPVLFQEALWHIPEHAVVLEIAPHALLQAVLKRGVKSSCTIIPLMKRDHKDNLEFFLTNLGKVHLTGINVNPNALFPPVEFPAPRGTPLISPHIKWDHSQTWDVPVAEDFPNGSSSSSATVYSIDASPESPDHYLVDHCIDGRVIFPGTGYLCLVWKTLARSLGLSLEETPVVFENVSFHQATILPKTGTVALEVRLLEASHAFEVSDTGNLIVSGKVYLWEDPNSKLFDHPEVPTPPESASVSRLTQGEVYKELRLRGYDYGPQFQGICEATLEGEQGKLLWKDNWVTFMDTMLQVSILGSSQQSLQLPTRVTAIYIDPATHRQKVYRLKEDTQVADVTTSRCLGITVSGGIHISRLQTTATSRRQQEQLVPTLEKFVFTPHMEAECLSESTALQKELQLCKGLARALQTKATQQGLKAAMLGQEDPPQHGLPRLLAAACQLQLNGNLQLELGEALAQERLLLPEDPLISGLLNSQALKACVDTALENLSTLKMKVAEVLAGEGHLYSRIPALLNTQPMLQLEYTATDRHPQALKDVQTKLQQHDVAQGQWNPSDPAPSSLGALDLLVCNCALATLGDPALALDNMVAALKEGGFLLVHTVLKGHALGETLACLPSEVQPAPSLLSQEEWESLFSRKALHLVGLKRSFYGTALFLCRRAIPQEKPIFLSVEDTSFQWVDSLKSTLATSSSQPVWLTAMDCPTSGVVGLVNCLRKEPGGHRIRCILLSNLSNTSHAPKLDPGSPELQQVLKHDLVMNVYRDGAWGAFRHFQLEQDKPKEQTAHAFVNVLTRGDLASIRWVSSPLKHTQPSSSGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLGMEFSGRDRCGRRVMGLVPAEGLATSVLLSSDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRIQRGETVLIHSGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQHVLLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVTFHGILLDALFEEANDSWREVAALLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHIGKVLVQVREEEPEAVLPGAQPTLISAISKTFCPAHKSYIITGGLGGFGLELARWLVLRGAQRLVLTSRSGIRTGYQAKHIREWRRQGIQVLVSTSNVSSLEGARALIAEATKLGPVGGVFNLAMVLRDAMLENQTPELFQDVNKPKYNGTLNLDRATREACPELDYFVAFSSVSCGRGNAGQTNYGFANSTMERICEQRRHDGLPGLAVQWGAIGDVGIVLEAMGTNDTVIGGTLPQRISSCMEVLDLFLNQPHAVLSSFVLAEKKAVAHGDGDTQRDLVKAVAHILGIRDLAGINLDSTLADLGLDSLMGVEVRQILEREHDLVLPMREVRQLTLRKLQEMSSKTDSATDTTAPKSRSDTSLKQNQLNLSTLLVNPEGPTLTQLNSVQSSERPLFLVHPIEGSTTVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQVQPEGPYRIAGYSFGACVAFEMCSQLQAQQGPAPTHNNLFLFDGSHTYVLAYTQSYRAKMTPGCEAEAEAEALCFFIKQFLDVEHSKVLEALLPLKSLEDRVAASVDLITKSHHSLDRRELSFAAVSFYHKLRAADQYKPKAKYHGNVTLLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDHRTLLEGSGLESIINIIHSSLAEPRVSVREG
What is the function of this protein?
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH.  This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
What are the official names of this protein?
Fatty acid synthase, Type I Fatty Acid Synthase.
What are the subcellular locations of this protein?
Cytoplasm. Melanosome.
Protein: CDD_SHEFN
Sequence: MQNRFLESITQLDKPLANALVPLLHDQFCGHIDASQFAGLVKASGKTEQQVLMDLLPIAAALANPPISEFYVGAIAKGSSGDLYMGANLELPGEALFHSVHAEQSAISHAWLSGETEIVDIIVNFSPCGHCRQFMNELVNGSKINIHLPNQETQTLAHYLPYAFGPSDLDVTVPLLCKREQEFNCDSDDPMIIEAIDQMGLSYAPYTNNNAAVVLETNDGATFCGRYAESAAFNPSMQPMQMALSNLIRNNRQYSEIKRAVLVESSVGKITLVGAAMDALHAIAPIELQHMVVEPLLG
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: RL19_SHESW
Sequence: MNNIIKMLNDEQMKQDVPAFGAGDTVVVQVRVKEGDKERLQAFEGVVIAKRNRGLHSAFTVRKISNGEGVERAFQTHSPLIASIEVKRRGRVRRAKLYYLRDRSGKSARIREKLATK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: GCS21_RUBXD
Sequence: MPVEFKLGNSGYTLGVEEELCIVDASTGELVPKIEEIMSRLPEDLAEAVSYELFQSVLEIKTPVCRTVGEAERVLRELRGRVGSWTAACGASLASAGTHPFSRYRDQKVTEHERYRQVIEELRWVATREVIFGQHVHVAVPGPEEAIQAHNRLAEQAPLLLALSANSPYWQGMDTGFESSRVQIFETFPRAGMPPAFPEYAAFEAYVDLMVECGAMDDYTFCWWDVRPHPKLGTIELRVLDSQTHLRHAVALTALTQCIVASSLEDEDAPKGPYHRDIALENKWRASRRGLDAAFFDVDERRNVPARDLARAAVERLRPHAQQLGCEEELLGVLEIVEGGSGSRRQREIYEKSGDFLDVVAFLIEGTRPALAGEPS
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2-1, Gamma-glutamylcysteine synthetase 2-1, GCS 2-1, Gamma-GCS 2-1.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: DNAJ_ECO5E
Sequence: MAKQDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAETKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQGGMGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKPGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVERSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNEKQKQLLQELQESFGGPTGEHNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_AZOVD
Sequence: MAKLTKRQKAIAAKVEAGKQYGFEEAAALLAELSTIKFKESVDIAINLGVDPRKSDQVVRGATVLPNGTGKDVRVAVFTQGPAAEAALAAGADRVGMDELAAEMKGGDLNYDVVIASPDAMRVVGQLGQILGPRGLMPNPKVGTVTPDVASAVKNAKAGQVRFRTDKNGIIHASVGKIDFEPIKLKQNVEALLSDLKRLKPSTSKGIYVKRVTLSSTMGPGLVIDQASLEA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: MKAR_YEAST
Sequence: MTFMQQLQEAGERFRCINGLLWVVFGLGVLKCTTLSLRFLALIFDLFLLPAVNFDKYGAKTGKYCAITGASDGIGKEFARQMAKRGFNLVLISRTQSKLEALQKELEDQHHVVVKILAIDIAEDKESNYESIKELCAQLPITVLVNNVGQSHSIPVPFLETEEKELRNIITINNTATLLITQIIAPKIVETVKAENKKSGTRGLILTMGSFGGLIPTPLLATYSGSKSFLQGWSNSLAGELSKDAIDVELIISYLVTSSMSKIRRSSLMIPNPQQFVKSTLRSVGRRCGSQERYATMTPYWAHAVYQFVITETFGVYSKIVNSINYSFHKSIRIRALKKAARQVKKE
What is the function of this protein?
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate.  Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation.  VLCFAs serve as precursors for ceramide and sphingolipids.
What are the official names of this protein?
Very-long-chain 3-oxoacyl-CoA reductase, 3-ketoacyl-CoA reductase, 3-ketoreductase, KAR, Microsomal beta-keto-reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single- pass membrane protein.
Protein: YIO2_SCHPO
Sequence: MRMQWIWKSRRSLQNVFIRRSSQYHKPFWRRPLPATLLGCAVLGVAAVYFAKPSPIDENYPRSVAKYLHEALYRQKGENNHDFQDAWKAYQSAIKQAESEKMDMESPPVQGIRLQMANLLASAGALHKAWSMYWDILERTSKLPDFLEQRVLIASKLIELSEPLGLQKDATKAADLIVKALLSKQFNGDDEQKSRLFEQSATLYFQAGTPSYAVPLYHEALNLTMANPSCHGLILMNNLATSLLAQTETVDKKHHETLMKQSQSWSQKAVDSYYFAYPKDRNQECHAGCAAAFYTLGQIAERQGNIDLALKHYKNSEALRKDDPYNDGSMLSHIAIDRLDKDAFIKKLDKSSSPTD
What are the official names of this protein?
TPR repeat-containing protein P27G11.02.
Protein: CRTP2_DICDI
Sequence: MSEEKLPLLSPLNENDIENDYKDENLKSDLDKLSNVKKQSIIQRFKDYLKNSISKQTATVLVYVVLYILSGVINSLLLKKVMNVFTNYGFFLNQLTNYGYVPIFGAIVLYKILFTNDIPKDTRSFPQWKFVIMGALDAVTGYFVVIGGIKTTGPLQQLLNQSVIPFTMLLSFIFLKERYSLIQLGGALIIIGGVVVSLIPSLTGGNTSGNMLFYNFFYLISMIPYAFSNVYKAIGFSTVEDMDVWYLQYFDALYQSLVGTVLFPINNWLPPPSDMKFNQVIPQLKAGGKCLGGINTLIEQYNSTTGELLPTSCNYGDNLGCDNCHGAWVVVLIYMAVNVLYNVFILLVLKHAGATVFSIANTLRLPLTNIAFSFKFIMGSDSNPFSGLSVAGLCIILLGLGGYRVGSMIKQKKEAAASADSSSNTENKVIPKVFPTQFGEVSIIIKKKVPPKSQTHLRNQFFGKLGITVPESKLRNQNSIYGDQ
What is the function of this protein?
May regulate endogenous transporter.
What are the official names of this protein?
Crt homolog 2, Chloroquine resistance transporter paralog 2, DdCRTp2.
What is the protein family that this protein belongs to?
Belongs to the CRT-like transporter family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: RL24_SHEPW
Sequence: MAAKIRRQDEVIVLAGKDQGKRGKVSQVLTTGKLIVEGINLVKKHQKPNPQLGVAGGIVEQEAPIQASNVAIFNSATGKADRVGFRFEDGKKVRFFKSNSELVK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: SYE_LEIXX
Sequence: MDVRVRFCPSPTGTPHVGMIRTALFNWAYARHTGGKFLFRIEDTDAARDSEESYGQIIDALRWLRLDWDEGVEVGGPHAPYRQSQRSSIYRELIEKLTASGHIYESFATGEEVEAHNIALGRDPKLGYDNFERDLTDAQKAAHRAEGREPALRLRVPDEDLSFDDLVRGEITFSAGSFSDFVVVRPNRQPLYTFVNPVDDALMGVTHVLRGEDLLSSTPRQIALYHALIETGVTTFVPRFGHLPYVMGEGNKKLSKRDPESNLFHHRDRGFIPEGLVNYLTLLGWSLSHDRDVFSIDEMVAAFDVGDVNPNPARFDQKKAESINGDHIRLLEVGDFAERTIPYLVAAGVLTEPITETQRAVLAEAAPLVQERVQLLGETPGMLGFLFAEAASVTIEDDARASLPANAGEALAASIGALELVPEAEWAHEAIEATLRDALVETLGFKPRIAFGPLRVALSGRRVSPPLFESMAILGKAETLARLVRLSAALG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_STRP1
Sequence: MSKQTFTTTFAGKPLVVEVGQVAKQANGATVVRYGDSTVLTAAVMSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFNGPIAGVQVGYIDGEFIINPDKEQMEASLLELTVAGSKEAINMVESGAKELSEDIMLEALLKGHQAIQELIAFQEQIVAVVGKEKAEVELLQVDVDLQADIVAKYNAQLQKAVQVEEKKAREAATEAVKEMVKAEYEERYAEDENLATIMRDVAEILEQMEHAEVRRLITEDKIRPDGRKIDEIRPLDAVVDFLPKVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLAPEYKKRFLHHYNFPQYSVGETGRYGAAGRREIGHGALGERALEQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGTNYTVLTDIQGLEDHFGDMDFKVAGTREGITALQMDIKIAGITPQILEEALAQAKKARFEILDVIEATIAEPRPELAPTAPKIDTIKIDVDKIKVVIGKGGETIDKIIAETGVKIDIDDEGNVSIYSSDQAAIDRTKEIIAGLVREAKVGEVYHAKVVRIEKFGAFVNLFDKTDALVHISEIAWTRTTNVSDVLEVGEDVDVKVIKIDEKGRVDASMKALIPRPPKPEKKEEKHD
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FER_CLOPA
Sequence: MAYKIADSCVSCGACASECPVNAISQGDSIFVIDADTCIDCGNCANVCPVGAPVQE
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
Protein: DNSL3_HUMAN
Sequence: MSRELAPLLLLLLSIHSALAMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVMEIKDSNNRICPILMEKLNRNSRRGITYNYVISSRLGRNTYKEQYAFLYKEKLVSVKRSYHYHDYQDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVKHRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKKSTNCAYDRIVLRGQEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTLRKKTKSKRS
What is the function of this protein?
Has DNA hydrolytic activity.  Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity).  Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:9070308, PubMed:9714828, PubMed:14646506, PubMed:10807908, PubMed:27293190).  Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis (PubMed:23229555, PubMed:24312463).  The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity).  Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:27293190).  Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity).  NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity).  Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
What are the official names of this protein?
Deoxyribonuclease gamma, DNase gamma, DNase I homolog protein DHP2, Deoxyribonuclease I-like 3, DNase I-like 3, Liver and spleen DNase, LS-DNase, LSD.
What is the protein family that this protein belongs to?
Belongs to the DNase I family.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum. Secreted. Note=Translocates from the endoplasmic reticulum to the nucleus during apoptosis (PubMed:23229555). Contradictory reports exist about the subcellular localization under normal physiological conditions. Under conditions of cell death, may diffuse and/or be actively transported to the nucleus.
Protein: RSMA_RHOPB
Sequence: MSGIDDLPPLRDVIKRHDLSARKSLGQNFLLDLNLLTRIARAAGPLDGATVIEIGPGPGGLTRALLALGAAKVIAIERDERALGALQEIAAHYPGRLEIVCADATIYDPRPLLGGARAKIVANLPYNIATPLLIGWLSIEPWPPWYDTMVLMFQREVAERIVAREDDEAYGRLAVLANWRAETKLLFDISPAAFVPQPKVTSSVVRLVPRETPEPCDRRMLEQVAAAAFGQRRKMLRQSLKPLGVDPARLAAAAGVDPTRRAETIAVSGFVAMARELTDIRAIKSV
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT2_TOBAC
Sequence: AGFAGDDAPRAVFPSIVGRPRYTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPLLLTEAPLNPKANREKMTEIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTAAEREIVRDLKEKLAYVSLVFEQELETSKNSKDVEKSYELPDGQIITIGAERFRCPEVLFQPSFIGMEAVGIHETTYNSIMKCDVDIRKDLYGNVVLSGGSTMFPGITDRMSKEISALAPNSMKIKVVAPPERKYSVWIGGSILASLSTFQQ
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.
What are the official names of this protein?
Actin-53.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: NCBP2_SCHPO
Sequence: MASITRLDAVSPYLIRRFKNDLRALDAVKQSNCVYVGNLSFYTTEEQIYALFSKCGEIRRIIMGVDRFTKTPCGFCFVEYFENQDALDSLKYISRTSLDERIIRADLDHGYEEGRQYGRGASGGQVRDEMREEFDPGRGGYAKNRQPTSSRQLANYSGISSAPLGSSLELQSNPRYNRWKKN
What is the function of this protein?
Component of the CBC complex, which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs.
What are the official names of this protein?
Nuclear cap-binding protein subunit 2, 20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, CBP20.
What is the protein family that this protein belongs to?
Belongs to the RRM NCBP2 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus.
Protein: RNPH_ERWT9
Sequence: MRPSGRSAQQVRPVTLTRHYTKHAEGSVLVEFGDTKVLCTATIEEGVPRFLKGKGQGWVTAEYGMLPRATHSRNAREAAKGKQGGRTLEIQRLIARSLRAAIDLKVLGEFTITLDCDVLQADGGTRTASITGACVALADALNHLVSTGKLKANPMKGMVAAISVGIVNGEALCDLEYVEDAAAETDMNVVMTEDGRMIEVQGTAEGEPFSHEELLKLLELARGGIDTLVAAQKAALTD
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: NUOD1_STRAW
Sequence: MSTSHASAASARETTEGTVYTVTGGDWDEVVQSAAKSDDERIVVNMGPQHPSTHGVLRLILEIDGETVTEARCGIGYLHTGIEKNLEYRTWTQGTTFVTRMDYLTPFFNETAYCLAVEKLLGIENEIPDRASIIRVLLMELNRMSSHLVCIATGGMELGATTIMIYGFRDRELILDIYELITGLRMNHAYIRPGGLAQDLPPGAVDQIREFVKKMKKNLPEYDKLATGNPIFKARMQDVGYLDLAGCMALGATGPILRSAGLPHDLRKSQPYCGYETYDFDVPTADTCDSYGRFLIRLEEMRQSLRIVEQCLDRLAPGPVMVADKKIAWPAQLALGPDGLGNSLDHIKKIMGTSMEALIHHFKLVTEGFRVPPGQTYSAVESPKGELGVHAVSDGGTRPYRVHFRDPSFTNLQAMAAMCEGGQVADVIVAVASIDPVMGGVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D 1, NADH dehydrogenase I subunit D 1, NDH-1 subunit D 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SP5G_ANAD2
Sequence: MEITEVRVFPVNEEKLKAYVTITLDHCFVIRDLKVIHGNTGLFIAMPAKRRKDGTFKDIAHPLNSDTREKMERTILAEYDRELKKGGAAPARATGTDPHED
What is the function of this protein?
Could be involved in septation.
What are the official names of this protein?
Putative septation protein SpoVG.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: SYDP_SHISS
Sequence: MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.