Protein: TOLL8_DROME
Sequence: MLATTHMLYVLIATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDITLVCHLRTINSELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQSCHVPINHASYHHHHHVHQQAMPLPHSVHHHQQQFMLPPPPQQPGSFRRQPSLHQQQQQQQQIRGNNNTTQQQQQQQAALLMGGGSVGGPAPQMIPLAGGIQQQSLPLPPNQQPTPASRNLHM
What is the function of this protein?
Toll-related receptor (PubMed:10973475).  Probably specific to larval innate immunity (PubMed:22022271).  Involved in the tracheal immune response of larvae to Gram-negative and perhaps Gram-positive bacteria; upon infection it negatively regulates the immune deficiency (Imd) signaling cascade specifically in the respiratory epithelium to prevent the overexpression of antimicrobial peptides (AMP) (PubMed:22022271).  Involved in the NF-kappa-B-dependent apoptosis of unfit cells during cell competition (PubMed:25477468).  Involved in neuron-specific glycosylation (PubMed:12588858, PubMed:17264077).  Positively controls the neuromuscular junction (NMJ) growth in presynaptic motorneurons, probably via the JNK pathway (PubMed:24662564).  During development of the peripheral nervous system, may function in the NF-kappa-B (rel) regulatory cascade to repress expression of the neuron-specific genes sc and ase in non-neuronal cells (PubMed:18000549).  Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762).  May have a minor role in leg development (PubMed:21158756).  May be involved in determining the proximal cell fate in the wing, possibly by negatively regulating the Dpp signaling pathway. (PubMed:17078066).  May also be involved in the Dpp signaling pathway in the eye (PubMed:17078066).  Possibly functions with 18w and Toll-6 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762).
What are the official names of this protein?
Toll-like receptor Tollo, Toll-like receptor 8.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Note=In larvae, localizes to the apical cell membrane in trachea epithelial cells.