PharMolix/UniProtQA huggingface dataset:
Protein: SKA1_BOVIN
Sequence: MASDLEQLCAHINEKIGNIKRTLSLRNCGQEPTLKTILNKIGDEIIVVNELLNKLELEIQYQEQTNSSLKELFESLEEDYKDVEHLKENIPPHLPQVTVTQNFVNGSDLDPEEPVKVEEPAPTKKPPKEQRSIKEMPFITSDEFNGIPAYMKSRLTYCHINDVIKEINKAVVSKYKILHQPKKSMSSVARNLYHRFIDEETKETKGHYFVVEADIKEFTTLKVDKRFHGILNILRHCRRLSEVRGKGLTRYVIT
What is the function of this protein?
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint.  The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies.  The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner.  Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.  In the complex, it mediates the interaction with microtubules.
What are the official names of this protein?
Spindle and kinetochore-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the SKA1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore- associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase and then vanishes in telophase.
Protein: CK021_HUMAN
Sequence: MGRTWCGMWRRRRPGRRSAVPRWPHLSSQSGVEPPDRWTGTPGWPSRDQEAPGSMMPPAAAQPSAHGALVPPATAHEPVDHPALHWLACCCCLSLPGQLPLAIRLGWDLDLEAGPSSGKLCPRARRWQPLPS
What are the official names of this protein?
Uncharacterized protein C11orf21.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_STAA8
Sequence: MFHHISVMLNETIDYLNVKENGVYIDCTLGGAGHALYLLNQLNDDGRLIAIDQDQTAIDNAKEVLKDHLHKVTFVHSNFRELTQILKDLNIEKVDGIYYDLGVSSPQLDIPERGFSYHHDATLDMRMDQTQELTAYEIVNNWSYEALVKIFYRYGEEKFSKQIARRIEAHREQQPITTTLELVDIIKEGIPAKARRKGGHPAKRVFQALRIAVNDELSAFEDSIEQAIELVKVDGRISVITFHSLEDRLCKQVFQEYEKGPEVPRGLPVIPEAYTPKLKRVNRKPITATEEDLDDNNRARSAKLRVAEILK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESF2_YARLI
Sequence: MARAKAVDFFSTKNNSSDSEEEEDKPAVDPRFVLADSDSEGEEEQEDGDEDEEEKGRTSKKKTKDFFELAGKTDDGDDEEEDEEDEEEEEEEKEKKPVKTSSTKAKTKPMTKEEIEKHNKKIAKTGVVYFSRIPPLMDPGKLRMLLQRFGIVDRIYLVPEDPKAQAVRIRHGGNRALAYTEGWAEFTKKRYAKTCASTLNGNTIGGKKGSQHYDDIMNAKYLPKFKWSDLSEQLAQETHNRQARLRTEISQATRENQTYIQSLEKSKAAERRRQRQEEEGGETEEKPAKKVHRDFYQGKTHSARAKEGKKELDGSVGSILGSVM
What is the function of this protein?
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis.  Required for the early cleavages at sites A0, A1 and A2 (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein ESF2, 18S rRNA factor 2.
What is the protein family that this protein belongs to?
Belongs to the ESF2/ABP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GLO18_ORYSI
Sequence: MMAAAGLESAWEYLITHFSEFQLASIGTFLLHESVFFLSGLPSLLFERLGLFSKYKIQKKSNTPDYQNRCVVRLVLYHVCVNLPLTILSYRTFKFMGLRSTLPLPHWTVVVSQVLFFFVLEDFIFYWGHRALHTKWLYQHVHSVHHEYATPFGLTSEYAHPAEILFLGFATVAGPALTGPHLFTLWVWMVLRVLETVEAHSGYHFPWSPSNFLPLYGGAEFHDYHHRVLYTKSGNYSSTFIYMDWLFGTDKDYRKTKALEEKERTKHL
What is the function of this protein?
Aldehyde decarbonylase involved in the conversion of aldehydes to alkanes.  Core component of a very-long-chain alkane synthesis complex.
What are the official names of this protein?
Very-long-chain aldehyde decarbonylase GL1-8, Protein GLOSSY 1-8.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YJ66_YEAST
Sequence: MVPKFYKLSNGFKIPSIALGTYDIPRSQTAEIVYEGVKCGYRHFDTAVLYGNEKEVGDGIIKWLNEDPGNHKREEIFYTTKLWNSQNGYKRAKAAIRQCLNEVSGLQYIDLLLIHSPLEGSKLRLETWRAMQEAVDEGLVKSIGVSNYGKKHIDELLNWPELKHKPVVNQIEISPWIMRQELADYCKSKGLVVEAFAPLCHGYKMTNPDLLKVCKEVDRNPGQVLIRWSLQHGYLPLPKTKTVKRLEGNLAAYNFELSDEQMKFLDHPDAYEPTDWECTDAP
What are the official names of this protein?
Uncharacterized oxidoreductase YJR096W.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: MNME_CHRVO
Sequence: MNLSYTPATICAVATAPGRGGVGVIRVSGKDLLPFAQAISGGKTPKPRYATYTDFFDAHGQALDNGLLLFFPGPNSFTGEDVIELQGHGGPVVLKMLLARCVELGARLAEPGEFTKRAFLNDKLDLAQAESVADLIDASSETAARSALKSLKGAFSREVHGLVDELINLRMLVEATLDFPEEEIDFLKQADAIGRLRRLRAQLVGVQATAKQGAILREGMHVVLVGQPNVGKSSLMNALAGDDIAIVTDIAGTTRDTVREEIVIDGVPVHIIDTAGLRDTDDVVEKIGIERTWQAVERADLALLLVDSREGLTAEVQSILERLPPALPRVQVFNKVDLSGEAAGLAEQDGHPLVRLSARTHDGVDILKAKLLEMIGYSGADEGVFLARQRHLDAIARAADHLELAEADWEQVEIFAEELRMAQNALSEITGEFSADDLLGVIFSRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_MUSDO
Sequence: KKLGKKGLTPSKIGIILRDSHGVAQVRFVNGNKILRIMKSVGLKPDIPEDLYHMIKKAVAIRKHLERNRKDKDGKFRLILVESRIHRLARYYKTKSVLPPNWKYESSTASALVA
What are the official names of this protein?
40S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RSMA_LATSS
Sequence: MEDIANPERTKKILKRYGFKFKKSLGQNFLTNITILKQIVEAGEITKDDDVIEIGPGIGSLTEQIARKAHQVLSFEIDDRLIPVLKDTLNHYHNVTVLNQDILEADLPTLIAKHFDGQHNLKIVANLPYYITTPIMLHLLEAGLPIDRMVLMMQKEVAERIDAAPGSKAYGSLSIAVQLHSEVKLAFIVPKTAFVPQPNVDSAIVEFVGRQEPLVTVQNQQLFDQLVRGAFAQRRKTLWNNLQNQFGKQEEVKAGLVAALDQADIAPSTRAEQLSIQQFAQLSDCLNEQPVFAKKRG
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSL_ARATH
Sequence: MSDDMVLHFSSNSSNQSDHSLPDKIAKLEARLTGKTPSSAKPPQQQQQQQQQVSLWSSASAAVKVVTSTPPGLSETSISDSDDENTGDFLIRANTKKRQKVQESNNFSVVDHVEPQEAAYDGRKNDAESKTGLDVSKKKQGRGRASSTGRGRGSKTNNDVTKSQFVVAPVSAASQLDASDQKDFRPDGQLRNGECSLQDEDLKSLRAKIAMLEEELRKSRQDSSEYHHLVRNLENEVKDLKDQEQQGKQKTTKVISDLLISVSKTERQEARTKVRNESLRLGSVGVLRTGTIIAETWEDGQMLKDLNAQLRQLLETKEAIERQRKLLKKRQNGDKNDGTDTESGAQEEDIIPDEVYKSRLTSIKREEEAVLRERERYTLEKGLLMREMKRIRDEDGSRFNHFPVLNSRYALLNLLGKGGFSEVYKAYDLVDHRYVACKLHGLNAQWSEEKKQSYIRHANRECEIHKSLVHHHIVRLWDKFHIDMHTFCTVLEYCSGKDLDAVLKATSNLPEKEARIIIVQIVQGLVYLNKKSQKIIHYDLKPGNVLFDEFGVAKVTDFGLSKIVEDNVGSQGMELTSQGAGTYWYLPPECFELNKTPMISSKVDVWSVGVLFYQMLFGKRPFGHDQSQERILREDTIIKAKKVEFPVTRPAISNEAKDLIRRCLTYNQEDRPDVLTMAQDPYLAYSKK
What is the function of this protein?
Required for correct initiation of floral organ primordia and for proper development of organ primordia.  Phosphorylates in vitro ASF1B/SGA1, the C-terminal part of TKI1 and histone H3.
What are the official names of this protein?
Serine/threonine-protein kinase TOUSLED.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: FURIN_BOVIN
Sequence: MELRPWLFWVVAAAGALVLLVADARGEKVFTNTWAVHIPGGPAVADRVARKHGFLNLGQIFGDYYHFWHRAVTKRSLSPHRLGHNRLQREPQVKWLEQQVAKRRAKRDIYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGYTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPAHLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSAFAPLAAGIIALTLEANKNLTWRDMQHLVVRTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCTIDILTEPKDIGKRLEVRKTVTACLGEPSHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPTPPESIGCKTLTSSQACVVCEEGFSLHQKNCVQHCPPGFAPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSSRESHQQQPPPPPRPPPAEVATEPRLRADLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
What is the function of this protein?
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:7806563).  Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity).  By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity).
What are the official names of this protein?
Furin, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE, Trans Golgi network protease furin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family. Furin subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
Protein: RBL2_RHOCB
Sequence: MDQSNRYARLDLKEADLIAGGRHVLCAYVMKPKAGYGYLETAAHFAAESSTGTNVEVSTTDDFTRGVDALVYEIDPEKEIMKIAYPVELFDRNIIDGRAMLCSFLTLTIGNNQGMGDVEYAKMHEFYVPPCYLRLFDGPSMNIADMWRVLGRPVVDGGMVVGTIIKPKLGLRPKPFADACYEFWLGGDFIKNDEPQGNQTFAPLKETIRLVADAMKRAQDETGEAKLFSANITADDHYEMVARGEYILETFGENADHVAFLVDGYVTGPAAITTARRQFPRQFLHYHRAGHGAVTSPQSMRGYTAFVLSKMSRLQGASGIHTGTMGYGKMEGDASDKIMAYMLTDEAAQGPFYHQDWLGMKATTPIISGGMNALRLPGFFDNLGHSNVIQTSGGGAFGHLDGGTAGAKSLRQSCDAWKAGVDLVTYAKSHRELARAFESFPNDADKLYPGWRVALGVN
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase, RuBisCO.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type II subfamily.
Protein: ERI2_DANRE
Sequence: MTTKRLAKELGLLRQRSASSSAQRSSVCKQRFSFLIIIDFESTCWREKSSSGQEIIEFPAVLLSVCSGAVESEFHSYVQPQERPVLSAFCTELTGITQDQVDSAPPLHVVLSRFSRWLRSLQEERGVVFLTDSSGAAPSAQLCAFVTWSDWDLGVCLLYECKRKQLSVPEALKNWIDLRATYKLFYNRKPKGLRGALLDLGIEFTGREHSGLVDARNTALLAQRMMTDGCQLSITSPERRAQVKPRPHTRPSGLRERHTHLTNVKNSRDTHTNTNTHLTNVKNSRDTHTNTHTHLTSVKNTRDTHTHTNTHLTNVKSSRDAHTRLPALMNGSIRARHTHTQQTCANSSDTHIASASVCEVLVSPYTLLSVAHTHTHLQARSAALAGLSDTTYDPESPAPCWQDGELLVEEEEPSSYDDVILGAEPEEATPSEPRRCVSSSVFKTPPPLLRSGPLSPLTHSLGRIAAPLSVHAHTHALKQKVKVTSPLCVCGRRARRLTVGNGGPNHGRVFYCCPRRRSNTHTHTCDFFQWESGVLQNTLSMLTTHTPAAAHTHLR
What are the official names of this protein?
ERI1 exoribonuclease 2, Exonuclease domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the ERI2 family.
Protein: RN2X3_LITCT
Sequence: GFLDIINKLGKTFAGHMLDKIKCTIGTCPPSP
What is the function of this protein?
Antibacterial activity against Gram-positive bacterium S. aureus (MIC=60 uM).  Shows no detectable hemolytic activity towards human erythrocytes.
What are the official names of this protein?
Ranatuerin-3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Ranatuerin subfamily.
Protein: PURT_BORPE
Sequence: MSTFPAPVLGTPLSPTATRVMLLGAGELGKEVVIALQRLGVEVIAVDRYADAPGHQVAHRAHVVSMTDPQALRQVIEQERPHVVVPEIEAIATDLLVALEDEGAVHVTPTARAAHLTMNREGIRRLAAETLGLPTSPYRFVDTEQALREAIDGGIGYPCVIKPVMSSSGKGQSIIRSADDIAAAWRYAQEGGRVGAGRVIVEGFIEFDYEITLLTVRARGADGQIVTQFCEPIGHRQVDGDYVESWQPHPMSPVALQRSREIALAVTGDLGGLGIFGVELFVAGDQVWFSEVSPRPHDTGMVTLISQVQNEFELHARALLGLPVDTRLRQPGASSVIYGGVDARGVAFEGVAQALAEPGTDIRLFGKPESYAKRRMGVGLAVADDVDQARAKAARVSQAVRVRA
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: MUTS_STAES
Sequence: MANITPMMQQYLKIKSEYDDCLLFFRLGDFYEMFFDDAKEASRVLEITLTKRDAKKENPIPMCGVPYHSADNYIETLINKGYKVAICEQMEDPKQTKGMVRREVVRIITPGTVMDQNGMDEKKNNYILSFIENEEFGLCYCDVSTGELKVTHFKDTATLLNEITTINPNEIVIKQALSEELKRQINMITETITVREDISDEDYDMNQLTHQLMHDTTQLLLDYIHHTQKRDLSHIEEVIEYAAVDYMKMDYYAKRNLELTESIRLKSKKGTLLWLMDETKTPMGARRLKQWIDRPLINKQQINDRLNIVEEFMDRFIERDTLRNHLNQVYDIERLVGRVSYGNVNARDLIQLKHSISEIPHIKALLNELGAQTTTQFKELEPLDDLLQILEESLVEEPPISIKDGGLFKNGFNAQLDEYLEASKNGKTWLAELQAKERERTGIKSLKISFNKVFGYFIEITRANLNNFQPEAFGYNRKQTLSNAERFITDELKEKEDIILGAEDKAVELEYELFVKLREHIKTYTERLQKQAKIISELDCLQSFAEIAQKYNYVKPTFSDDKVLHLENSRHPVVERVMDYNDYVPNDCHLDDETFIYLITGPNMSGKSTYMRQVAIISIMAQMGAYVPCDSATLPIFDQIFTRIGAADDLVSGKSTFMVEMLEAQKALTYATENSLIIFDEIGRGTSTYDGLALAQAMIEYVAQTSHAKTLFSTHYHELTSLDQMLKCLKNVHVAANEYQGELIFLHKVKDGAVDDSYGIQVAKLADLPNEVIDRAQVILNAFEQKPSYQLSHENTDNQQTVPSYNDFGRTEEEQSVIETHTSNHNYEQATFDLFDGYNQQSEVECQIRELNLSNMTPLEALIKLNELQSQLK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RRF_CLOBH
Sequence: MIKEILKKADEKMGKTIVALKKELASMKAGRANPAMLDRIEAEYYGSMTPLNQLGNISVPEARVLLIQPWDKGALSAIEKAILKSDLGLNPSNDGTVIRLVIPELTEETRKNIVKTVKKTGEEAKVAIRSIRRDCNDDVKNLKKDDVSEDDIKKAEDDIQKKTDKYIKEIDSIISAKEKEILSI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HGD_RHILO
Sequence: MVNTGRLGFVKLGAGIKEDRMAFSYMPGFGNDFETETLPGSLPQGRNSPQRPAYGLYAEQLSGSPFTAPRGTNERSWLYRIRPSVKHTGRFKAASYPLWKTAPNVGDHELALGQYRWNPVPMPKEPTDFIQGMRSITTAGDVLGQTGMAAHVYVANRSMVDDHFFNADGELLVVPQVGALRFVTEMGVIELRPGEIAVLPRGLVFKAELVDKDVRGYVCENYGAKLTLPDRGPIGANCLANPRDFKTPCAWFEEKETPCRLIVKWCGNFHVTEIGHSPLDVVAWHGNYAPYKYDLATFSPVGAILFDHPDPSIFTVLTAPSGEEGTANIDFVIFPPRWLVAEDTFRPPWYHRNIMSEFMGLIHGQYDAKEEGFVPGGISLHNLMLAHGPDAPGFEKASRADLKPVKLDNTMAFMFETRFPQMLTRYGAELETRQDNYIDCWADLKKRFNGTPEGDWS
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: AERA_AEREN
Sequence: MKALKITGLSLIISATLAAQTNAAEPIYPDQLRLFSLGEDVCGTDYRPINREEAQSVRNNIVAMMGQWQISGLANNWVILGPGYNGEIKPGKASTTWCYPTRPATAEIPVLPAFNIPDGDAVDVQWRMVHDSANFIKPVSYLAHYLGYAWVGGDHSQFVGDDMDVIQEGDDWVLRGNDGGKCDGYRCNEKSSIRVSNFAYTLDPGSFSHGDVTQSERTLVHTVVGWATNISDTPQSGYDVTLNYTTMSNWSKTNTYGLSEKVSTKNKFKWPLVGETEVSIEIAANQSWASQNGGAVTTALSQSVRPVVPARSRVPVKIELYKANISYPYEFKADMSYDLTFNGFLRWGGNAWHTHPEDRPTLSHTFAIGPFKDKASSIRYQWDKRYLPGEMKWWDWNWAIQQNGLATMQDSLARVLRPVRASITGDFRAESQFAGNIEIGTPVPLGSDSKVRRTRSVDGANTGLKLDIPLDAQELAELGFENVTLSVTPARN
What is the function of this protein?
Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death.  The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter (By similarity).
What are the official names of this protein?
Aerolysin.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane. Note=Secreted as a soluble precursor.
Protein: ASTD_SHIDS
Sequence: MTLWINGDWVTGQGALRVKRNPVSGEVLWQGNDADAAQVEQACRAARAAYPRWARLSFGDRQVRVERFAGLLESNKAELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHVRTGEQRSEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGEAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHRQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLLLKSGAQGDAFLARLVAVSQRLTPGNWDDEPQPFIGGLISEQAAQQVVTAWQQLEAMGGRTLLAPRLFQAETSLLTPGIIEMTGVAGVPDEEVFGPLLRVWRCDTFDEAIRMANNTRFGLSCGLVSSEREKFDQLLLEARAGIVNWKKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLLAMLNPGLDFSDEV
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: ISPDF_RUEPO
Sequence: MTTAAIIVAAGRGTRAGGGVPKQWRPLAGRRVADWTLDRFALRQITHVVLVLHPEDHDAWDEFATTPLILAPGGSDRAGSVRNGLAALDGLGITKVLIHDVARPCVSAATIGAVLDALDAHPGAAPGLAVTDALWTGAEGLVTGTRERDGLFAAQTPQGFRYDAIVAAHAAHPGGAADDVEVARAAELTVAIVPGDPDNLKITRAEDFARAERILRQDMDVRLGNGYDVHRFGPGDHVILCGIKVPHDRGLQGHSDADVGMHAVTDALYGALVEGDIGRHFPPSDPQWKGAASEIFLRHAVDLVRARGFAVSNIDCTLVCEYPKIGPHALEMQAEMARIMGLEASRVSVKATTSERLGFTGRSEGIAALATACLVKP
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: Y3675_BACHK
Sequence: MFGQRQSMIVYLHSLKHAKILRKYGNIHYISKRLKYAVVYCDMEQIEHMMQKLNKLPFVKKIEQSYRPYLKTEFENSRPDRAKEYDYS
What are the official names of this protein?
UPF0298 protein BT9727_3675.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TVA17_HUMAN
Sequence: METLLGVSLVILWLQLARVNSQQGEEDPQALSIQEGENATMNCSYKTSINNLQWYRQNSGRGLVHLILIRSNEREKHSGRLRVTLDTSKKSSSLLITASRAADTASYFCATD
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 17.
What are the subcellular locations of this protein?
Cell membrane.
Protein: EBDG_STRAW
Sequence: MFHRPASVRRFVTTAVALGLLSTLSTGARAGARTHEPPPRPTTVSSTAGSTTALTGYAIQSTAKVTDPAAAVSSPGYPASGWYPAGARSTVLAALLAGGKYADPFYSTNQQKIPKADFQVPWWYRSDFTVADTSARTYLDFSGVISAADVFVNGRQIARSADVAGAYTRHELDVTSLVREGANTVAFRIQPNNPNKNLTMGWIDWLEPPPDQNMGIVRDVLVRRGGPVALRDAHVITRLDVPSLATADLTVKARARNDSDAAITATVSGSVGATSFRRSVALAAHETKTVTFTPADTPGLHLTSPRVWWPAGMGGQPLYALDLSASVSETVSDTVHESFGIRDVKAPLNSDGARQYSVNGRRLLIKGGGWSPDEFLRWDSTYVEDRLRYALDLGLNTIRLEGHIEPDEFFDLADRYGILTLPGWECCNKWEGNVNGSGSGDEWTAADYPVAKASMAAEAARLRDHPSVVSFLIGSDFAPDAKIEKTYLDALKAADWPTPVVAAASDKSSPVSGSSGMKMTGPYDWIPPNYWYAKREGGATGFNSETSAGPDIPTLDTLRRMMTPAELDTLWKNPGAKQYHRSPSSVFGTLKIYDAALAGRYGAPTGLTDYVRKAQLAQYENVRAQFEAYGRGATDASKPATGVIYWMFNSGWTSLHWQLLDRYLDQGGAYFGAKKANEPLHVQYSYDDRSVVVVNNRPAAVSGLTARVTLFNTDGTQKYDKSATGLSVAGDGAHSTALTLPSSVSGLSTTYLARLVLTDSAGKEVSRNVYWLSTRPDTLDWAHTDWYYTPTTSYADLKGLGSMARVPVSATASTTAGTDGASTTTVTVRNTGSGRTPSLFTDVHLVDSKGKPVLPVQWSDNEVSLWPGESATLTVTYRTADLHGSAPRVRVSGWNTAEQTVPAA
What is the function of this protein?
Hydrolyzes chitosan and chitooligosaccharides with retention of anomeric configuration.  Has no beta-mannosidase activity.
What are the official names of this protein?
Exo-beta-D-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YLI2_SCHPO
Sequence: MSSHKPVRPNEALHKEALEELDAKINEAKKRFNEHKEKLGAIRGGGSLQEKNAELRAELDNIRNAQAAIRSSKQTLINKVKAQDELLKKKVKELTAMKKTVPFKSEVELDKHVKQLQAAVDSGTLKIVDEKKYLREISQCNRTRKSFVELNALQTSIDTIRNELNELRDQLNDSESKKLSDKFVEIRSELDEVRKQQDGYYKDQRKLIAERDDEKTALDDLYNQRRALQREYDTQLRAFRTYEREQRAKRQEQFRLERENREKEKRRIAAQRKLEEASIPAFTEEILACENLLKVFHVPVESSTTNAVSTGNTSSKILKPRTLTPRTVDPIPEGTIIKKESSDDAMFSGLKKSKPKKSNKSNNNQADSDRLNLSFGTIKEFDFVGVPAPFTKSQVDSAVEQLKSRIAHFKEQQDSVTKQRIEKAKQEIEKLEAKYNSKEEKTLTEADMVISSEETVTVTNDLEVEATA
What are the official names of this protein?
Uncharacterized protein C458.02c.
What are the subcellular locations of this protein?
Cytoplasm.