PharMolix/UniProtQA huggingface dataset:
Protein: RL10_MACFA
Sequence: MGRRPARRYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS
What is the function of this protein?
Component of the large ribosomal subunit.  Plays a role in the formation of actively translating ribosomes.  May play a role in the embryonic brain development.
What are the official names of this protein?
60S ribosomal protein L10, Ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: COQ7_PSEE4
Sequence: MATERHYSPLDRLLLQADTAMRTLLPFSGQPARPSPAIIQPDAELDEQQTRHIAGLMRINHTGEVCAQALYQGQALTAKLPQVRKAMEHAAEEEIDHLAWCEQRIRQLNSHPSVLNPLFYGMSFGIGALAGLVSDKVSLGFVAATEHQVCKHLDEHLEQIPENDGKSRAILEQMRVDEEHHAESALEAGGYRFPAPVRFGMSLLAKVMTKSTYRI
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRMN6_ECO5T
Sequence: MSQSTSVLRRNGFTFKQFFVAHDRCAMKAGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTSDSVIIDAVELESEAATQAQENVAQSPWLERINVHTADIQQWVTQQTARFDLIISNPPYYEQGVECATPQREQARYTTSLDHQTLLTCAAECITEEGFFCVVLPEQIGNSFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYSEAYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_PSEMY
Sequence: MTDSTLRHITVLLDEAVEGLAVRADGCYIDGTFGRGGHSRLILHKLGPGGRLLGFDKDPLAIATGEALAAEDGRFVVVQRSFAELGDEAVVRGISGQVSGVLLDLGVSSPQLDDPERGFSFLNDGPLDMRMNPDVGVSAADWIATAEEDEIARVLKDYGEERFAKRMARAVVQRREQQPFTRTADLAKVLTEANPAWEKGKNPATRAFQGIRIYVNNELGDLERGLDAALEALEVGGRLVVISFHSLEDRIVKQFMKRQAKGEADKLPRDLPIIPKAFEPRLKLIGKPVYAGDAELKANPRSRSAVMRIAEKLR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMPA_SHIFL
Sequence: MSTVYHRPADPSGDDSYVRPLFADRCQAGFPSPATDYAEQELDLNSYCISRPAATFFLRASGESMNQAGVQNGDLLVVDRAEKPQHGDIVIAEIDGEFTVKRLLLRPRPALEPVSDSPEFRTLYPENICIFGVVTHVIHRTRELR
What is the function of this protein?
Involved in UV protection and mutation.
What are the official names of this protein?
Protein ImpA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: SECA_CHLAA
Sequence: MMNFLRRLLGDSNEKELRRLQPIVEEINRLGPEFAALSDAELRAKTDEFRQRLADGETLDDILPEAFATVREAAHRTIGLRHYDVQLIGGIVLHQGKIAEMKTGEGKTLVATLPLYLNALEGKGVHLVTVNDYLAKVGAGWMGPIYHFLGLTVGFIAHDQSALYDPDFIDPDANPEDQRLVHWRPCTRREAYLADITYGTNNEFGFDYLRDNMAYEKSQLVQRELHYAIVDEVDNILIDEARTPLIISGPAQKSSDLYRQMAQLVRQLRRSSVTAKQVKEEGLEPDGDFFVDERTKSIYLSEKGIEKLERLLRIPPGESLFDPEHYEKTHYIENALKAQFIYQRDRDYMVTPNGEVVIIDEFTGRAMPGRRWSDGLHQAVEAKEGVAIKNENVTLATITFQNYFRMYKKLAGMTGTAYTEREEFAKIYNLEVVVIPTHKPMIREDLPDQIYATEEAKFNAVLREVQEMHEIGRPVLIGTTSVETSERISAMLKRAGIPHNVLNAKHHEREAAIIAQAGRKGAVTVATNMAGRGTDILLGGNPDGLLEEFLRKEGLTIETATPEQKRAAWEKARAQTEAEGEEVRRLGGLHVIGTERHEARRIDNQLRGRAGRQGDPGSSRFFLSLEDELLRRFGPVDRIKGLMERFVDSDVPLQAGLLDRTIEGAQTRVEGYNFDVRKHTVEFDDVMNKQRQIIYADRKAILDEADMRERVLDLMAEEIQRQIDEHLIDGFEEEDLTNLLRAYRRINSTLPASVTAETLKGKTKEEIEQYLLDHLETTYAERERAVTPELMRTIERRVMLGAIDRQWVDYLTAMDELRQNILLQAYAQRDPLVEFKRESFRMFDELKQNIARDIVYNIIPATFQYEAYLRQIAEEQARRLATAQTVSSDGNGEVVRKPQRRSTPQIGRNELCPCGSGKKFKHCHLGREHELASLLNAQPSAPPASKALKSTPATQTAVAEEAAKIQAAINSGKLPPTQTTPRGRQAPSVPRGKKR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: GCSH2_AQUAE
Sequence: MAEKVEEYRGCVIPKDLYYDIENQVWFKVNEDGTVTVGVTDIGQARAGKIINIRIKPPGKYVKKGKPVASLESGKWAGPVPADIEGEVVERNEKLFDKPDLINEDPYGEGWIAKLKPANLERDLQDLVTGEEAVQKLKEYIEREDVNCGEERAQISKKFYK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein 2.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: Y2106_PYRCJ
Sequence: MKRIVTLVSREQAEVGHRFRVFGIPDECRECRLYSVCLGRLTPGRSYIVVEVRPSMGQKCKITGGEMVPVVVEETPIVGLLPLNKALEGVVVTYEDECAGCDGCPSNMVSKGEKIKVVKVLGRAKCRGREFAIVEFYALGAPSLSGASSAGISQAPSRVPLSKPPSKSPSPQKSSPRGPTSRLP
What are the official names of this protein?
UPF0179 protein Pcal_2106.
What is the protein family that this protein belongs to?
Belongs to the UPF0179 family.
Protein: TSAD_BACCZ
Sequence: MGEYIMEKNTIILGIETSCDETAVAVVKNGTEIIANVVASQIESHKRFGGVVPEIASRHHVEEITVVLEEALKEANITFDDIDAIAVTEGPGLVGALLIGVNAAKAVAFAHDIPLVGVHHIAGHIYANRLVKEVQFPLLSLVVSGGHTELVYMKEHGSFEVIGETRDDAAGEAYDKVARTLSMPYPGGPHIDRLAHEGKPTIDLPRAWLEPDSYDFSFSGLKSAVINTVHNAKQRGIEIAPEDLAASFQESVIDVLVTKASRAADAYNVKQVLLAGGVAANKGLRARLETEFAQKENVELIIPPLSLCTDNAAMIAAAGTIAYEQGKRATLALNANPGLDIEA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNB_SODGM
Sequence: MFQDNPLLAQLKQQLHSQTPRVEGVVKGTEKGFGFLEVDAQKSYFISPPFMKKVMHGDKISAVVRTEKEREIAEPEELIEPFLTRFIGRVQVKDERLAVVPDHPLIKEVIPTRPQHGVDQMFQTGDWAVAEMRRHPLKGDRQFYAEITALVTRADDHFAPWWVTLARHNLERAAPTMPEGVSLQEDGPAREDLTALDFITIDSASTEDMDDAIHLAPAPNGAWVMTVAIADPTAWVPAGSPLDNIARERAFTNYLPGFNIPMLPRALSDDLCSLRAHERRPALACRVTVRPNGTLADDARFFTAWIESKGKLAYDNVSDWLENLGSWQPETEAIADQIRLLHDVCLARSAWRQRHALVFKDRPDYRFVLNEKGNVDDIVVEPRRIANRMIEEAMITANVCAARVLRDGLGYGLYNVHHGFDPLLVDQAVAILHSHQIEVDPADLLTLEGFCALRRRLDAQPTSYLDSRIRRFQTFAEVSTVPGPHFGLGLDAYATWTSPIRKYGDMINHRLLKALIGVGDAERPNEEVTLRLAERRRQNRMAERDVGDWLYARFLQPKAGSDSRFAAEIIDISRGGMRVRLLNNGAVAFIPAPFIHSVRDELVCSQDTGTVQVKGEERYRQGDTLDVTLAEVRMENRSVIARPV
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_RHORT
Sequence: MIAKLKGLVDSVAEDHAVIDVGGVGYLVFCPARVLTRLPSPGQAVALVVETQVREDHISLFGFLETAERDWFRLLSTVQGVGSKVALSVLSVLSAGQISQAIAAGDKAALGRAPGVGPKLAARIASELKDKAVALGGMPAPPPRGAGTDAAGEGPPGGPTGDVLGDAVSALVNLGYGRSEAVGAASRAAGLGATTVQGVIGLALRDLGRGGA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: TREF_SALAR
Sequence: MLHQKLNPTSSEDLTIDVDLLYETDPCELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSTKLFPDSKTFPDCAPKMDPLDILIRYRKVRRHRDFDLRRFVENHFWLPETLSSEYVSNPENSLKEHIDQLWPILTREPQDHIPWSSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVFALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLALNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVETAKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDAGRLASIRTTQFIPIDLNAFLYKLESAIANISALKGERDTEALFRQKASDRRAAVNHYLWDDENGCYRDYDWRREEMALFSAASIVPLYVGMANHEQADRLANVVRSRLLTPGGIMATEYETGEQWDKPNGWAPLQWMAIQGFKLYGDDMLGDEIAHNWLKTVNHFYQEHHKLIEKYHISGGTPREGGGGEYPLQDGFGWTNGVVRRLIGLYGEP
What is the function of this protein?
Hydrolyzes trehalose to glucose.  Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
What are the official names of this protein?
Cytoplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYEP_MOUSE
Sequence: MWLELILASVLGFVIYWFVSRDKEETLPLEDGWWGPGSKPSAKEDESIRPFKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSSYLKKVVSFWRNEFDWRKQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLLTDPKTHGLSDEHVFEVICPSIPGYGFSEASSKKGLNSVATARIFYKLMSRLGFQKFYIQGGDWGSLICTNIAQMVPNHVKGLHLNMSFISRNIYSLTPLLGQRFGRFLGYTEKDLELLYPFKEKVFYNIMRESGYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFSLEDLLTNIMIYWTTGTIVSSQRFYKENLGQGVMVHRHEGMKVFVPTGYSAFPSEILHAPEKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAELQ
What is the function of this protein?
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.  May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids.  Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity).
What are the official names of this protein?
Epoxide hydrolase 1, Epoxide hydratase, Microsomal epoxide hydrolase, mEH.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: MEL_VESMG
Sequence: MKFLVNVALVFMVVYISFIYAAPEPEPAPEAEAEADAEADPEAGIGAVLKVLTTGLPALISWIKRKRQQG
What is the function of this protein?
Main toxin of bee venom with strong hemolytic activity and antimicrobial activity.  It has enhancing effects on bee venom phospholipase A2 activity.  This amphipathic toxin binds to negatively charged membrane surface and forms pore by inserting into lipid bilayers inducing the leakage of ions and molecules and the enhancement of permeability that ultimately leads to cell lysis.  It acts as a voltage-gated pore with higher selectivity for anions over cations.  The ion conductance has been shown to be voltage-dependent.  Self-association of melittin in membranes is promoted by high ionic strength, but not by the presence of negatively charged lipids.  In vivo, intradermal injection into healthy human volunteers produce sharp pain sensation and an inflammatory response.  It produces pain by activating primary nociceptor cells directly and indirectly due to its ability to activate plasma membrane phospholipase A2 and its pore-forming activity.
What are the official names of this protein?
Melittin, MEL, MLT.
What is the protein family that this protein belongs to?
Belongs to the melittin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Alpha-helical peptides form toroidal pores in the prey.
Protein: HEM1_SYNSC
Sequence: MHISVVGLSHRTAPVEIRERLSIPEQTMETSLQSLRGNEQVLEASILSTCNRLEIYTLVRNPDLGVSAVSDFLSSHSGLETGELTPHLFSYHHEDAVDHLMRVAAGLDSLVLGEGQILSQVKKMMRLGQEHKSLGPILNRLLTQAVTTGKRVRSETNLGTGAVSISSAAVELAQLKLGQSRGLDHLVTLESEQIAVVGAGRMSRLLLQHLQAKGASGVVLLNRTVERAEQLSADFPDLPVQCRPLTDLDQYLSTCSLMFTSTAADDPIIDAARLAPLNRRSKLRLIDIGVPRNIAADAADVNGVESHDVDDLQEVVARNQEARQAMAREAEQLLQQEAQQFLEWWDSLEAVPTINQLRSSMESIRTEELQKALSRMGPDFSARERKVVEALSKGIINKILHTPVTQLRAPQTRQDRQQALRIVERLFDLEAS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: Y7162_DICDI
Sequence: MSTCEITSGNCRNFPLILAVDCAIIIPNTNFIHSFLIYSLRI
What are the official names of this protein?
Putative uncharacterized protein DDB_G0275485.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AES_ECO5E
Sequence: MKPENKLPVLDLISAEMKTVVNTLQPDLPPWPATGTIAEQRQYYTLERRFWNAGAPEMATKAYMVPTKYGQVETRLFCPQPDSPATLFYLHGGGFILGNLDTHDRIMRLLASYSQCTVIGIDYTLSPEARFPQVIEEIVAACCYFHQQAEDYQINMSRIGFAGDSAGAMLALASALWLRDKQIDCGKVAGVLLWYGLYGLRDSVTRRLLGGVWDGLTQQDLQMYEEAYLSNDADRESPYYCLFNNDLTREVPPCFIAGAEFDPLLDDSRLLYQTLAAHQQPCEFKLYPGTLHAFLHYSRMMKTADEALRDGAQFFTAQL
What is the function of this protein?
Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons).  Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate.  Negatively regulates MalT activity by antagonizing maltotriose binding.  Inhibits MelA galactosidase activity.
What are the official names of this protein?
Acetyl esterase.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHQA_EMENI
Sequence: MEPITIPTDRDGVAYLYGHPLRNSLSPPLHQTVYNALGLNWTQIPLSTATGTSFTRSPEISTFLSSVRSNPKFVGSSVTMPWKVAIMPHLDDLTEDARQAGACNTIYLRKEDDGKTQYVGTNTDCIGIREALLQGSPNGAEHFKGKPALIVGGGGTARTAIYVLRKWLGVSKIYIVNRDAKEVEAILAEDKQRNPSPQVALVPVSDPSAAATLEAPVAVVSGIPNYPPQTEEEIRARETLRVFLNRQTHEKDQGVILEMCYHPLPWTDIAQIAQDARWKVILGSEALIWQGLEQARLWTGKDVVSEPGLVEKVQAFVAQTIAERSKSNL
What are the official names of this protein?
Quinate dehydrogenase.
Protein: PUR2_VIBVY
Sequence: MNVLIIGSGGREHALGWKAAQNPNVETIFVAPGNAGTALEPKLENVNIAVEDIAGLVAFAKEKAIELTIVGPEVPLVLGVVDAFYEAGLPIFGPTQAAAQLEGSKAFTKDFLARHQIPTAAYANFTDIEPALAYVREQGAPIVVKADGLAAGKGVIVAMTLEEAEEAIKDMLAGNAFGEAGSRVVIEEFLDGEEASFIVMVDGENVLPMATSQDHKRVGDKDTGPNTGGMGAYSPAPVVTPEIHNRVMQEVIFPTVRGMAAEGNPYTGFLYAGLMIDKDGTPKVIEYNCRFGDPETQPIMMRMESDLVELCLAAIDKKLDQVESKWDPRASIGIVLAAGGYPAAYNKGDVISGLPQVEIEGEKVFHAGTENKGGDIVTNGGRVLCATALGNSVSEAQQRAYELAKQIRWDGMFHRNDIGYRAIAREQQK
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: NDHO_PROM0
Sequence: MTDSIPKKPLKKGSLVFVDKENYIKSIEALASDHDLPNYVFEGPGEILSVKDEYAQIRWRRPVPDVWFKLEQLKEYLQ
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit O, NAD(P)H dehydrogenase I subunit O, NDH-1 subunit O, NDH-O.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhO subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GYRA_STAAR
Sequence: MAELPQSRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKKSARIVGDVMGKYHPHGDLSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESETDKVAMESLQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELEAILADEEVLLQLVRDELTEIRDRFGDDRRTEIQLGGFEDLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRGVQGMNTLEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELENDEIISTMIAVKDLESEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAVRLTSGQEDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANSVDEVLVVTENGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGVIIRLDVADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDADEENEDEQSTVSEDGTEQQREAVVNDETPGNAIHTEVIDSEVNDEDGRIEVRQDFMDRVEEDIQQSSDDDEE
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AFPR2_CUCMA
Sequence: QGIGVGDNDGKRGKR
What is the function of this protein?
Has strong antifungal activity against B. cinerea, C. albicans, C. coccodes, F. oxysporum, F. solani, T. harzianum and T. viride with EC(50) values of 20 uM, 20 uM, 10 uM, 10 uM, 10 uM, 20 uM and 20 uM, respectively.  Has antifungal activity against A. fumigatus, A. parasiticus and D. byroniae with EC(50) values of 40 uM, 80 uM and 40 uM, respectively.  Lacks antifungal activity against P. verrucosum var.  verrucosum.  Lacks antibacterial activity against the Gram-negative bacterium E. coli and against the Gram-positive bacterium S. aureus.  Has very low hemolytic activity against human erythrocytes.  Increases fungal cell membrane permeability, probably by disrupting the membrane structure.
What are the official names of this protein?
Antifungal protein Pr-2.
Protein: YG35_YEAST
Sequence: MGRTIRRRRSNSSLSEAISVSLGINQDSSVNKMHRASVSAMSPPLCRSYMSGFFTGGNSPMINNLSDSKLPISNKQHPKVIHGSENLHRQTAQLSNEFCSSSVEENSPTIKDYMDIIGNGDRKDDQSMRTIEENIDEEYSDEYSRLLLSPASSNVDDDRNRGLQNSSLPELEDGYAGGYQSLRPSHNLRFRPRNLWHMCTSFPSKFAHYLPAAVLGLLLNILDALSYGMIIFPITEPVFSHLGPTGISMFYISTIISQAVYSGGWSSFPSGIGSEMIEITPFYHTMALAIKEALAGNDDEIITTTIFCYVISSMLTGVVFYALGKLRLGKIVGFFPRHILIGCIGGVGYFLIITGIEVTTRVAKFEYSWPFFSGLFTDYDTLAKWLLPVLLTVVLIGTQRYFKNSLVLPSFYILTLVLFHFIVAIIPTLSLDALRQAGWIFPIANSDSKWYDHYRLFNVHKVHWSLVLQQIPTMMALTFFGILHVPINVPALAMSLQMDKYDVDRELIAHGYSNFFSGLLGSVQNYLVYTNSVLFIRAGADSPFAGFLLIALTICIMIIGPVIISFIPICIVGSLIFLLGYELLVEALVDTWNKLNRFEYLTVVIIVFTMGIFDFVLGIIVGILIACFSFLVDSTKLQTINGEYNGNVARSTVYRDYVQTKFLDGIGEQIYVLKLQNLLFFGTIISIEEKIERLLQISNKDATKRRIKYLILDFKNINADNIDYSAAEGFNRIKRFTETKRIKLIISSIKERDRIYNAFNNVGLLNDVELFADLNSALEWCENEFLFQYKQLRKKAKERLEEGKQNNVVSAVIAATKNKKIDTIGNGLNRGSNGDTARNLMSLPTNTPRNYQILSVAQNVFVNDEQAVKNFKKEYKDDEPVLPILLFALKQYRPDIISEVQKVREKEIKFWAQLCPYFTRRRLASQSHLLHADNIFFLVETGMLKATYELPQGTLYEIFSNGTCFGKIIAPGNAMPREQKLTIETETDSVLWVIDSSSLNKLKEDNLALYVEVALMVMCIKDTRFKELLGYTLVSA
What are the official names of this protein?
Uncharacterized vacuolar membrane protein YGR125W.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: YJCO_ECOLI
Sequence: MKKIIALMLFLTFFAHANDSEPGSQYLKAAEAGDRRAQYFLADSWFSSGDLSKAEYWAQKAADSGDADACALLAQIKITNPVSLDYPQAKVLAEKAAQAGSKEGEVTLAHILVNTQAGKPDYPKAISLLENASEDLENDSAVDAQMLLGLIYANGVGIKADDDKATWYFKRSSAISRTGYSEYWAGMMFLNGEEGFIEKNKQKALHWLNLSCMEGFDTGCEEFEKLTNG
What are the official names of this protein?
Sel1-repeat-containing protein YjcO.
Protein: ARGP_YERP3
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENLFGQPLLVRTVPPRPTEQGQKLLALLHQVELLEEEWLGNDNGVDTPLLLSLAVNADSLATWLLPALKPVLADLPIRLNLQVEDETRTQERLRRGEVVGAVSIQPQPLPSCLVDQLGALDYLFVASKAFAERYFPNGVTRSALLKAPAVAFDHLDDMHQAFLQQNFDLSPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELASGELIDLTPGLLQRRMLFWHRFAPESRTMRKVTDALLSYGRQVLRQDSFIGQ
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: SDHE_PHOLL
Sequence: MDIDNKARIHWACRRGMRELDISIMPFFKYEYDSLSDDDKRLFIRLLACADPDLFNWLMNHGRPEDEELFRMIKLIQNRNKDRGPVEV
What is the function of this protein?
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins.  Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
What are the official names of this protein?
FAD assembly factor SdhE.
What is the protein family that this protein belongs to?
Belongs to the SdhE FAD assembly factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_CORDI
Sequence: MVSMPNPILDAAAGVTPHRRPVWFMRQAGRSLPEYREIREGVSMLDSCFRPDMLAEITLQPVRRHDVDAAILFSDIVVPLKAAGVRVEIVPGRGPVMDHPLLTRQDIENLPILDHDVHEVAEGIGIIREELNDAQTLIGFAGAPFTLASYLVEGGPSKNHEKTKSLMHQDPESWHLLMRRLVPTIVQFLRTQIDAGVQAMQLFDSWAGFLSERDYREFVLPYSMEILAQVGDVPRIHFGVGTGELLTAMSEAGSEVVGVDWRVPLDVAAQRMVSPKVLQGNLDPAILFAGEDVMRREIARICAEADRAIAAGHATGHIFNLGHGVLPNTDPDAITRAVEIIHTF
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.