PharMolix/UniProtQA huggingface dataset:
Protein: ITPA_PUCGT
Sequence: MGALKLVFVTGNANKLREVKKILSTDVSSEDSLKIEVDSKALDLPEVQGSTQDVAREKSRAAAKLIGGPCITEDTALCFKAMGGLPGPYIKWFLEKLGLDGLNKMLQGFSSTEATALCTFAYCEPGKEPILFEGATEGNIVPARGPTNFGWDPIFEVSGTGMTYAEMPAEQKNSLSHRSKALDKLRQHFSRR
What is the function of this protein?
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RM38_BOVIN
Sequence: MAAPWWRVVLNGSRNWRGFSTSAALSRRAAPLGPMPNEDIDVSNLERLKKYRSFDRYRRRAEREARDPHWWRTYREHFGEESDPKDTVDIGLPPPKVCRTQQLLERKRVLRELRTSVEEERASRLRTASIPLEAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVAYAIGEDDLVPVYYGNEVTPTEAAQPPEVTYEADEGSMWTLLLTNLDGHLLEPDAEYVHWLVTNIPGSRVAEGEETCPYLPPFPARGSGFHRFAFLLFKQDKPVDFSGDTRPSPCYQLAQRTFHTFDFYKKHQDAMTPAGLAFFQCRWDDSVTHIFHQLLDMREPVFEFVRPPPYHPKQKCFPHRQPLRYLDRYRDSHEPTYGFY
What are the official names of this protein?
39S ribosomal protein L38, mitochondrial, L38mt, MRP-L38.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PKS1_METBS
Sequence: MNHVTIKQSDTRADPFRVFIFGDQSSCNLSNLQLLLFKKSNVYLASFIDQVNLTLRHEVARLTAAERQSFPAFSSVQNLVARALKKDTSVALESTLATIYHLCCFINYFGDGQEAYPTGPTTHVSGLCIGALAAAAVSSSKSLAELVQAGIDAVRVSLKVGLLVARTAALFSHQESNGTSSPPWSYAVPDSQLPLALAEEAIESYQAKTNIPPLSLPYISAKGQNSWTASGPPAIVQHFLETSQFEKTLRLTPLAVHAPYHAPHIFSAIDVQHIIRAVGPVSSFSSKLSFISSSSSRNLATGLKFQDLLYRAVEDILILPLDLREAAENIRLVLEATDNVQQCALFPISTGVGPSLKQSFSPAMASRVSIVDCIMERVAADAGPKSTSGPKPSESKIAIIGMSGRFPESADVEAFWDLLHQGLDVHRPVPPDRFNGELYYDVTGKRKNTCKVMHGCWINDPGLFDAKFFNISPKEAEQSDPGQRLALATAYEALEAAGVVADRTPSTQRDRVGVFYGMTSDDYREVSCGQNVDTYFIPGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWRNECDTAIAGGTNVMSNPDSFVGLDRGYFLSRTGNCHTFDDEADGYCRADAVGTVILKRLEDAIADHDPILGVISGALTNHSADAVSITRPHSGAQEEIFSKLLTESGVHPHQVSYIEMHGTGTQAGDATEMTSVLNCFAPSTSTRRLPHESLHLGSTKANVGHSESASGVSALIKVLLMMEKNIIPPHCGIKGKINHKFPTDLDERNVHIAKTATQWNRRNELNNIRRAFVNNFSAAGGNTALLVEDYPLLIADSSQPDGRTAHVVTVSAKSIKSLKGNLENLKKFVQKQASTEGFLPKLSYTTTARRMHHPFRVAIPAANSEQLLSALNEELTHDSYTCCSESPVAFVFSGQGSQYSAMGQHLLHFTIFRDEVHAYDILAQRHGFPSIMPLIDGSVDIEDLEPLVVQLGTVCVQMALASLWMALGMRPAYVVGHSLGHYAALKVAGVLTASDTIYLVATRARLLQNKCSRGSHAMLAIRSSAAEIQAHLDEGIHDIACINGPQDTVVSGCIDDIDRLSQKLMDKGIKATRVNVPFAFHSAQVDPILDELEAVASQVEFHAPRVAIGCPLLSKTFKAGETPSLEAKHIRRHCRETVNFLDVLRSAKDDGLVSEKTAWIEIGPHTVCSNLVKANINQDITAVPSLMRNKDGWQVLASSVATLYRQGSSVAWDEYHHDFEACKQVLRLPAYSWDNKLYWIDYVHDWLLTRGDPPVQAAASLPAPPSSFSTASVHRIVHESVEKGKLTLTAECEFTNEQLHEVVYGHLVNGNRVCSSSLYTDFGVTLGSYILEKYRPDLQGHAVDVQDMVVNKALVHKEGPTMLLRIDVVLDTTDSKAASMSIYSVNSKGNKTADHAQSSLHFEQPKVWLKSWDSTQYYVERSIEWLKEKADQGLNSRMSSGVIYKLFSSLVDYSTAYKGMQEAIVNTEDFEATALVRFQVDEGNFRCNPMWVDSCGQLAGFLMNGHAKTPKDQVFINHGWQYFRTVRKFSRDKTYRTYVRMRCVEGTTYAGDVYIFDDDGIVGVCGSITFQGIPRKVLNTAMPPPKSQNEAPVRSGPAKPAVKPPRSASSEHSGHFARHANIEPLKLDAALKSATTARNPMLPVFKIVAEEIGIPSAGVDNGLVFADYGVDSLLSLSISGRLREELDLDVESSAFETCATLADLAAHLGMDTFSADQSSGQSSSSGGLSPRSDSIGEMTSSATTPPSMSPRGSVSGSQCKDVCAILAEEIGVSMGEITNDTDLGALGMDSLMSLAVLSRLREELELDLEGDFFVSHPNFSSFKHMFQQGHGDEAEPETSAELKQYRATSTLLQGSPKSALYTLFLLPDGSGSSFSYAPINAVRKDVCVFGLNCPWLKSAEKLVQFGLKGLATLYVEEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGETVERLILLDSPNPIGLEKLPARLFDFVNGLGLFGDGKAPDWLLAHFLAFIDALDEWKPVPWDKALGGSSPPPMTYILWAEDGICKGTDARPEYRDDDPREMKWLLENRTNFGGNNWDVLLGQQSLSIERIQDANHFTMLRKGKNTERVAAFIRSIFG
What is the function of this protein?
Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:29958281).  The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity).  The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity).
What are the official names of this protein?
Polyketide synthase 1, Conidial pigment biosynthesis polyketide synthase.
Protein: CLPB_ECOL6
Sequence: MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVSPLLTSAGINAGQLRTDINQALNRLPQVEGTGGDVQPSQDLVRVLNLCDKLAQKRGDNFISSELFVLAALESRGTLADILKAAGATTANITQAIEQMRGGESVNDQGAEDQRQALKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLALDMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSKPEELDRLDRRIIQLKLEQQALMKESDEASKKRLDMLNEELSDKERQYSELEEEWKAEKASLSGTQTIKAELEQAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQLEGKTMRLLRNKVTDAEIAEVLARWTGIPVSRMMESEREKLLRMEQELHHRVIGQNEAVDAVSNAIRRSRAGLADPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDEAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNLGSDLIQERFGELDYAHMKELVLGVVSHNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLKRLYKRLEERGYEIHISDEALKLLSENGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKVIRLEVNEDRIVAVQ
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASP7_CHICK
Sequence: MSGDQHADRSSGEKSNGDQDDTVDAKPDRSSRLSLFAKKKKNGEEEQPKSSLSNQYRIVTPTFQYNMNYKKVGKCIIINNKNFEDKTGMGTRNGTDKDAGDLSKSFRSLGFDVYTYNDRSCEDMQTLLKQAAEENHSDAACFACILLSHGEEGLIYGTDGPMAIKHLTTLFRGDKCKTLIGKPKLFFIQACRGSEFDEGIQTDSGPANDTLETDANPRYKIPVEADFLFAYSTVPGYYSWRNPGRGSWFVQSLCSVLNEHGKQLEIMQILTRVNYVVATNFESQSDDPRFSEKKQIPCVVSMLTKELYF
What is the function of this protein?
Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:14583630).  Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (By similarity).  Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity).  Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8 and/or CASP9), mediates execution of apoptosis by catalyzing cleavage of proteins (PubMed:14583630).  Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (By similarity).  Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (By similarity).
What are the official names of this protein?
Caspase-7, CASP-7.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
Protein: CYAY_ECO57
Sequence: MNDSEFHRLADQLWLTIEERLDDWDGDSDIDCEINGGVLTITFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWICDRSGETFRDLLEQAATQQAGETVSFR
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: UNG_STACT
Sequence: MNWSEVFHDITNRHDFKEMHDFLDKEYSTKTVYPDKENIYQAFDLTPFDKVKVVIIGQDPYHGPKQAHGLAFSVQPEGKFPPSLRNMYKELEDDIGCKRTVSHLQDWAREGVLLLNTVLTVRKGEAASHRNIGWEVFTDEIIKAVSEYRDHVVFILWGKPAQQKERLIDTSKHDVIKSVHPSPLSAYRGFFGSKPYSRANTYLEAHGETPIDWCGEEAQRG
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_SALCH
Sequence: MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFDNGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLNGYQHYDTAAAVTCALLRGLSREPLRTGRILNVNVPDLPLAQVKGIRVTRCGSRHPADKVIPQEDPRGNTLYWIGPPGDKYDAGPDTDFAAVDEGYVSVTPLHVDLTAHSAHDVVSDWLDSVGVGTQW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPR_ECO7I
Sequence: MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKDH
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_RHIL3
Sequence: MTDSLTHTSPFLVAALYHFVSVPRFADLQAPLQTLCEENGVKGTLLLAHEGINGTIAGPDAGIHAVLAFLRAQPEFSGLEHKESRASKMPFLRMKVKLKKEIVTMGVEDIDPNKVVGTYVAAKDWNTLISDPDTIVIDTRNDYETAIGTFRGALDPKTKSFREFPEWVRQNPGLHNKPKVAMYCTGGIRCEKATAFMKAEGFDEVYHLKGGILKYLEEVPQEESLWDGACFVFDERVSVEHGLKEGEHRLCHACRNPITAEETTSPLYEEGVSCSHCYHTRTEEDRLRYRQRQHQIALAKKRGQRHIGS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: YIDC1_BACAN
Sequence: MLKSYRAVLVSLSLLLVFVLSGCSNATPIDAHSTGIWDHYFVYPISFMIQFVAHHIPGASFGIAIIIMTLVIRSAMIPLAVSQYRSQAKMKKMQPELQKLKQKYGDVSKDLEKQKQYQKEMSELMKSGGWNPLAGCWPLLIQMPIFSALYYAISRTEEIRTSTFLWVNLGHADPYHILPIIAALTTFIQMKVFQSNSTSGEQVQMLKMQQIMMPAMILFMGFAAPSGLVLYWITGNLFTMMQTIVLRKIMEREELQLQKA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC 1, Foldase YidC 1, Membrane integrase YidC 1, Membrane protein YidC 1.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTND_GRABC
Sequence: MSRLTIYADSTPDAPLLRTEDPERIAQELSSIGVRFERWSSAVTPSPDDDEATILAAYRPYLNALMGETGAGTADVIRLRPDTPNLPALRQKFLSEHTHTEDEVRFFVHGSGNFILHVDDRVYDAHCTQGDLISVPTGIKHWFDAGETPFVTALRVFTDTTGWVAHYTGDPIADHFPAA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: ADA12_MOUSE
Sequence: MAERPARRAPPARALLLALAGALLAPRAARGMSLWDQRGTYEVARASLLSKDPGIPGQSIPAKDHPDVLTVQLQLESRDLILSLERNEGLIANGFTETHYLQDGTDVSLTRNHTDHCYYHGHVQGDAASVVSLSTCSGLRGLIMFENKTYSLEPMKNTTDSYKLVPAESMTNIQGLCGSQHNKSNLTMEDVSPGTSQMRARRHKRETLKMTKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDIDKCSISQDPFTSLHEFLDWRKIKLLPRKSHDNAQLISGVYFQGTTIGMAPIMSMCTAEQSGGVVMDHSDSPLGAAVTLAHELGHNFGMNHDTLERGCSCRMAAEKGGCIMNPSTGFPFPMVFSSCSRKDLEASLEKGMGMCLFNLPEVKQAFGGRKCGNGYVEEGEECDCGEPEECTNRCCNATTCTLKPDAVCAHGQCCEDCQLKPPGTACRGSSNSCDLPEFCTGTAPHCPANVYLHDGHPCQGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKSAFAKCELRDAKCGKIQCQGGASRPVIGTNAVSIETNIPQQEGGRILCRGTHVYLGDDMPDPGLVLAGTKCAEGKICLNRRCQNISVFGVHKCAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTVGILVSILCLLAAGFVVYLKRKTLMRLLFTHKKTTMEKLRCVHPSRTPSGPHLGQAHHTPGKGLLMNRAPHFNTPKDRHSLKCQNMDISRPLDARAVPQLQSPQRVLLPLHQTPRAPSGPARPLPASPAVRQAQGIRKPSPPQKPLPADPLSRTSRLTSALVRTPGQQEPGHRPAPIRPAPKHQVPRPSHNAYIK
What is the function of this protein?
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion.  Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, Meltrin-alpha.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SCMK_BACSU
Sequence: MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELAKTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYSEPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIVKGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQAGSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPIIADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKSRFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIMPPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK
What is the function of this protein?
Probably catalyzes the oxygenation of the 2-position of the succinyl moiety of N-acetyl-S-(2-succino)cysteine, causing a spontaneous elimination reaction of the resulting hemithioketal that generates oxaloacetate and N-acetylcysteine (NAC).  Is involved in a S-(2-succino)cysteine (2SC) degradation pathway that allows B. subtilis to grow on 2SC as a sole sulfur source, via its metabolization to cysteine.
What are the official names of this protein?
N-acetyl-S-(2-succino)cysteine monooxygenase, S-(2-succino)cysteine metabolism operon protein K.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family.
Protein: LIPA_STAAW
Sequence: MATKNEEILRKPDWLKIKLNTNENYTGLKKMMREKNLNTVCEEAKCPNIHECWGARRTATFMILGAVCTRACRFCAVKTGLPNELDLNEPERVAESVELMNLKHVVITAVARDDLRDAGSNVYAETVRKVRERNPFTTIEILPSDMGGDYDALETLMASRPDILNHNIETVRRLTPRVRARATYDRTLEFLRRSKELQPDIPTKSSIMVGLGETIEEIYETMDDLRANDVDILTIGQYLQPSRKHLKVQKYYTPLEFGKLRKVAMDKGFKHCQAGPLVRSSYHADEQVNEAAKEKQRQGEAQLNS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_LIGS1
Sequence: MYDEERIVSGDSFEGEDLNEQSLRPQTFDQYIGQKLLKDEISVYIQAAKQREESLDHVLLYGPPGLGKTTLAIVIANEMGVKIKTTTGPAIEKPGDLVALLNELEPGDVLFIDEIHRLPKNVEEILYSAMEDYFIDIIVGQGPTAHPVHFPLPPFTLVGATTRAGLLSAPLRARFGIVGHMEYYNEVDLSQIIKRSAQILSTGIDDEGAHEIARRSRGTPRVANRLLKRVRDFAEVKHKDKIDTEIVQFALDLLRVDKVGLDRTDRKLLKAMIELYDGGPVGLNTIAANIGEESDTIADMIEPYLMQIGFIKRTPRGRMVTLAAYEHLGIKYNKEG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SNX24_MOUSE
Sequence: MEVYIPSFRHEDSDLERGYTVFKIEVLMNGRKHFVEKRYSEFHALHKKLKKCIKTPEIPSKHVRNWVPKVLEQRRQGLETYLQAVILENEELPKLFLDFLNVRHLPSLPKAESCGSFDETESEESSKLSHQPVLLFLGDPYVLPAASDFPNVVIEGVLHGIFFSHLQPR
What is the function of this protein?
May be involved in several stages of intracellular trafficking.
What are the official names of this protein?
Sorting nexin-24.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y4615_BACAN
Sequence: MDGFDKTMKFSIQDEKQSVHVNDVLLTVYDALQEKGYNPINQIVGYLLSGDPAYIPRHKDARSIIRKLERDELIEELVKSYLKHHREE
What are the official names of this protein?
UPF0297 protein BA_4615/GBAA_4615/BAS4283.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: RL36_ACIBY
Sequence: MKVQASVKKICGSCKVIRRNGVIRVICSAEPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: KAE1_ASPFU
Sequence: MIAIGLEGSANKLGVGIMLHPEDGSTPRVLANIRHTYVSPPGEGFLPKDTARHHRSWVVKLVKRALREARISVRDVDCICFTKGPGMGAPLQSVAVAARMLSLLWGKELVGVNHCVGHIEMGRLITGSTNPVVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLHISNDPAPGYNIEQLAKKGKQLVDLPYTVKGMDCSFSGILAAIDGLAASYGLNGEEKEEEGAGDDSKPTRADLCFSLQETVFSMLVEITERAMAHVGSKEVLIVGGVGCNERLQEMMGIMARDRGGSVHATDERFCIDNGIMIAQAGLLAYKTGFRTPLKESTCTQRFRTDDVFVKWRD
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein kae1, tRNA threonylcarbamoyladenosine biosynthesis protein kae1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EST_GEOSE
Sequence: MKIVPPKPFFFEAGERAVLLLHGFTGNSADVRMLGRFLESKGYTCHAPIYKGHGVPPEELVHTGPDDWWQDVMNGYEFLKNKGYEKIAVAGLSLGGVFSLKLGYTVPIEGIVTMCAPMYIKSEETMYEGVLEYAREYKKREGKSEEQIEQEMEKFKQTPMKTLKALQELIADVRDHLDLIYAPTFVVQARHDEMINPDSANIIYNEIESPVKQIKWYEQSGHVITLDQEKDQLHEDIYAFLESLDW
What is the function of this protein?
Involved in the detoxification of xenobiotics.  Shows maximal activity with C6 substrates, with gradually decreasing activity from C8 to C12 substrates.  No activity for higher chain length substrates acids rather than long-chain ones.
What are the official names of this protein?
Carboxylesterase.
What is the protein family that this protein belongs to?
Belongs to the lipase/esterase LIP3/BchO family.
Protein: MNMG_GEOSL
Sequence: MNLIDYEKQYDVIVAGAGHAGCEAALAAARMGCETLLLTINLDAIALMSCNPAIGGLAKGHLVKEIDALGGEMGKNIDATGIQYRILNTRKGPAVRASRAQADKQLYRLRMKHVMEEQEHLSLKQGEVTGLVVEDGRVRGVVTKVGVRFLGKTVILTTGTFMRGLIHVGLTNYPGGRAGDLPSVGLSDQLRDLGFTVGRLKTGTPARLDGNTIDFSRLEPQYGDDPPVPFSFSTERIDRPQLPCYIAYTNERTHEIIRSGLDRSPLYSGVIEGVGPRYCPSIEDKVMRFPDKDRHQSFLEPEGRDTVEYYPSGLSTSLPIDIQYRLYRSIEGLENVEIMRPAYAIEYDYVDPIQLHTSLETKLIRNLYHAGQINGTSGYEEAAGQGLMAGINAALRVQGEEPLVLGRDEAYIGVMIDDLVTLGTREPYRMFTSRAEYRLLLREDNADLRLRERGHAVGLVRDEEYRLFLEKRERIGAELERLRTAKLLPSEADPSFLETYGMTDLRNALTFEQLLRRPDITYEELSQIDPVAGMVPPSVKEQVEIQIKYQGYIERQLDQVARARKLEGTRIPDDLDYTVIPGLSAEVREKLLRFLPDTLGQASRIQGVTPAAVGILSVAIKSRSASS
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.