PharMolix/UniProtQA huggingface dataset:
Protein: SYL_MYCCT
Sequence: MDFSHKAIEKKWQKYWKENNVYKTTDSNHKKAYVLDMFPYPSGAGLHVGHIKGYTATDVYSRFKRMQGYDVLHPIGWDAFGLPAEQYALKTGNDPRDFTLKNIENFKAQLVKMGFSYDYDKEINTADPNYYKVTQWIFKELYKKGLAENRNIDVNWCQELGTVLANDEIIEKDGLMVSERGEYPVVKKKMRQWVLKITDYADKLLKGLDNLDWPNSVKELQRNWIGKSEGCEINFKSNDINIPVFTTRADTVFGATYIVLAPENELVLKLTTPNKLDEVKKYIELTANKSEIERKDESKTKTGVFIGSYAINPLTKEQIQIWISDYVLNDYGSGAIMAVPAHDKRDWDFATKFNLPIRFVISTKDESKAFVGEGKHINSEFLNDLDRIQSLQVIHDYIEKNNLGKKKTNYKLRDWLFSRQRFYGEPFPVLYDKDNNIILVEDDDLPITLPKTDYIKPTNTGESPLANVKNWVNVKIGDREYKRETNTMPQSAGSSWYFIAYILANSKNNLIDLTSDEAKKRLEKWLPVDLYIGGQEHAVGHLLYSRFWTHFLYDLGLLPTSEPFQRLFNQGMILGPDNRKMSKSWGNVINPDDVIDTHGADALRLYEMFMGPLDASLPWSFDGLDASLKWLNRCYRMINKIEFSNTNNHKLDYVYNDVVKKVTQMITELKFNTAISQLMVLVNAIYKEELSTVYKPYIEGFVKMLSLFSPHLAEELWEKLGNNSSVTLQAWPEFDETKIVKNTVVIALQVNGKLRSTIEVEKGTDKETLIKLAQENENIIRFIKGHKNLKYIAVVDRIVNIVIE
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_META1
Sequence: MAVVPKRKTSKQRKALRRSHHALEALTLVECKNCKQSIVPHQACKYCGFYKDKKVIKVALNDQVK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RL14_TERTT
Sequence: MIQTETYLDVADNSGARRVMCIKVLGGSHRRYAGVGDVIKVTVKEAIPRGKVKKGQVMKAVVVRTKKGVRRPDGSLIRFDDNAAVLLNNQEAPVGTRIFGPVTRELRGEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: DNAK_BACFR
Sequence: MGKIIGIDLGTTNSCVSVFEGNEPVVIANSEGKRTTPSIVAFVDGGERKVGDPAKRQAITNPTRTIFSIKRFMGENWDQVQKEIARVPYKVVKGDNNTPRVDIDGRLYTPQEISAMILQKMKKTAEDYLGQEVTEAVITVPAYFSDSQRQATKEAGQIAGLEVKRIVNEPTAAALAYGLDKAHKDMKIAVFDLGGGTFDISILEFGGGVFEVLSTNGDTHLGGDDFDQVIIDWLVQEFKNDEGADLTQDPMAMQRLKEAAEKAKIELSSSTSTEINLPYIMPVGGVPKHLVKTLTRAKFESLAHNLIQACLEPCKKAMQDAGLSNSDIDEVILVGGSSRIPAVQKLVEDFFGKTPSKGVNPDEVVAVGAAVQGAVLTDEIKGVVLLDVTPLSMGIETLGGVMTKLIDANTTIPARKSETFSTAADNQTEVTIHVLQGERPMAAQNKSIGQFNLTGIAPARRGVPQIEVTFDIDANGILKVSAKDKATGKEQAIRIEASSGLSKEEIEKMKAEAEANAEADKKEREKIDKLNQADSLIFQTETQLKELGDKLPADKKAPIEAALQKLKDAHKAQDMTTIDSAMAELNTAFQAASAEMYAQSGAQGGAQAGPDMNAGQSNAGQNNGKQDDNVQDADFEEVK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: DNAJ_LEPBJ
Sequence: MSERSYYDILGVSKSANDEEIKSAYRKLAIKYHPDKNKGNKESEEKFKEATEAYEILRDPKKRQAYDQFGKAGVGAGAGGFGQGAYTDFSDIFGDFGDIFGDFFGGGRGGFGGGRRSGSQRGSDLRYNLEVSLEDAALGREYKIEIPRLESCGDCNGSGAAKGSSPTTCPDCGGSGQIRRTQGFFSVATTCPTCRGKGTTISNPCKTCGGQGLQEKRRTINIKIPPGVETGSRLKVSGEGEAGPNGGSHGDLYVVTHIKRHELFERQGNDLILVRKITLAQAILGAEIEVPTIDGKKAKMKIPEGTESGQVFRLKGHGMPYLGAYGKGDQHVVVKIEIPKKITRRQRELIEAFARESGENIPGSKGKIFTK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_BACFR
Sequence: MTLIDGKAISEQVKQEIAAEVAEIVAHGGKRPHLAAILVGHDGGSETYVAAKVKACEVCGFKSSLIRYESDVTEDELLAKVRELNEDDDVDGFIVQLPLPKHISEQKVIETIDYRKDVDGFHPINVGRMSIGLPCYVSATPNGILELLKRYRIETSGKKCVVLGRSNIVGKPMAALMMQKAYPGDATVTVCHSRSKDLVKECREADIIIAALGQPNFVKAEMVKEGAVVIDVGTTRVPDASKKSGFKLTGDVKFDEVSPKCSFITPVPGGVGPMTIVSLMKNTLLAGKKAIYQ
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SEY1_ASPFC
Sequence: MATNGHFASIGVDNDKTAYEHGVQVIDENKEFNPNISKYLSLENVTHAGFNYHLISVFGSQSTGKSTLLNHLFGTHFSVMSDSERRQTTKGIWMSKNKREGEATVDPTLRMADNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLQLFLKDKNTTHRSLLFFVIRDFVGTTPLKNLQKTLMEDMARLWESISKPPGLESSSVHDYFDFQFYGLPHKSYQPEQFVAETKKLSLRFREGQRDPSMDARRGEFSEGGVFLPEYHRRIPADGFSRYAEGIWDQIVNNKDLDLPTQQELLAQFRCDEILREVMIAFDEAIVPFEEKQSQSARLGEPEVLGGLGAAMRSSRAKAVKNFETEASRYHKGVYQRKRAELESKVDTRLKALLQGQLNAAHKSGINEFSEAVSSSVKSGQKQGAGYDFAEIVNEEVKKAIAKFEDVARSTVVEGTTWSDYKQELALYEKELADVSGRLRREEMRRLANRVERWVQSRLGESVGLEFNALGSGRAGGGAPETGEKPLEKAFWDRVWNVFVETVLDAERRFTDRASSFDASLEEVDVGLWRLRRKSWGVLRAKIDEEMTEGNLLLKLRENFEDKFRYDDAGVPRIWRPTDDIEGIYTRARESTLTLIPLLSRFRLAETSAPPPLDRWIGHTPSSATPADEEDLPPIGGVDEEEGKSLDEEMMILSEAKRQELTVRFKKAADGVYVEAKRSAIGGMTQVPLYFYGLLLALGWNEIIAVLRNPAYFFLLFICAVGAYVTYQLNLWGPIIKMTEAASSQALVEGKKRLREFLESSDTGRQAIAMSAGSGRSGEQYELSDLSKKGKARTSADEDMDDL
What is the function of this protein?
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein sey1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: DOT6_YEAST
Sequence: MSISTSLNSASIHLSSMDTHPQLHSLTRQPHSSSTAMSKNEAQESSPSLPASSSSSTSASASASSKNSSKNPSSWDPQDDLLLRHLKEVKKMGWKDISQYFPNRTPNACQFRWRRLKSGNLKSNKTALIDINTYTGPLKITHGDETANAQQKPSKKVEENVLTEDTAEFTTTSSIPIPSRKTSLPSFHASMSFSQSPSNVTPTTIVSNAASSMPFAPPTLPAALPHHPHQHLHHHPHHKTLKPRSNSHSFTNSLNQDPIVRSNDEEKYGFIPKVFVRSRRSSFAYPQQVAITTTPSSPNSSHVLLSSKSRRGSLANWSRRSSFNVSSNNTSRRSSMILAPNSVSNIFNVNNSGSNTASTSNTNSRRESVIKKEFQQRLNNLSNSGGPTSNNGPIFPNSYTFMDLPHSSSVSSSSTLHKSKRGSFSGHSMKSSCNPTNLWSKDEDALLMENKKRNLSVMELSILLPQRTEVEIQWRLNALSSDADMLSPTHSPQKTLSKKTCPRMFKSGSTTDDDKGSDKEDVMGDGSNDDDEDNVDPLHRAKQSSNKTVFSSSSSNISSKDVSPDPIFSPDPADDSSNTSDAGSRCTITSDTSSSAATMNRTPNSKNPQDIALLNNFRSEAITPRPKPSSTTTSITTETTNNMINHSSSTTTTTNNSPLPSINTIFKDML
What is the function of this protein?
Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  DOT6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif.
What are the official names of this protein?
Transcriptional regulatory protein DOT6, Disrupter of telomere silencing protein 6, PAC-binding factor 2.
What is the protein family that this protein belongs to?
Belongs to the DOT6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDAD_THEAC
Sequence: MSGFVPTHIFFTRGVGRGETQLVSFEAALRDAGIAPYNLSSISSIFPPHAEMITREEGLKKLSPGQILFTVLARNTSNELNRMVSAAIGYAIPRDRSKWGYLSEHHSFGETEKVAGSFAEKLAAEMLASTIGSSAQLAYDKQKEEYVLEDKILTTGSISSTAVVLESGEWTTVVAAAVLIVE
What are the official names of this protein?
Pyruvoyl-dependent arginine decarboxylase, PvlArgDC.
What is the protein family that this protein belongs to?
Belongs to the PdaD family.
Protein: ZB16A_DANRE
Sequence: MDLTKMGMIQLQNPNHPNALLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKVEDLDDLLYAAEILEIEYLEEQCLKILETIQSSDENDTEVNMNDGGTEDDEERKGRHGRNLVGSKKHSTEESGYVSAAQQALALPGMVDQSPSVSTSFGLSTMSPTKAAVDSLMSIGQSLLQSTMHPGVGAEQPLHGNSHPMMGEIKTEMMQVDESGEHESPKAMESIASSNGERSGEPDKNRDGPGTPTRSSVITSARELHYVRDEGLGDQQAEVSQMGLEAMAGMTEKHLASLYGIPSNHKNEAMLSMPASMASSLHMSPALAMSMDFSAYGGLLPQSFIQREFFSKLGELAAGIKPDGRSLNERCNVCGAELPDNEAIEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLSHSAGEKAIVCDQCGAQFQKEDALEAHRQIHTGSDMAIFCLLCGKRFQTQTALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTAGDHPFECEFCGSCFRDESTLKGHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICLEYCPSLSAMQKHMKGHKPEDIPPDWRIEKTYLYLCYV
What is the function of this protein?
Probable transcription factor.  Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  Inhibits neurogenesis.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 16-A, Promyelocytic leukemia zinc finger protein-A, Zinc finger protein PLZF-A.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear export to the cytoplasm is promoted by btbd6a.
Protein: BIOB_STAHJ
Sequence: MRFNLAERILNQDVLSKDEALALFEDETIDTFELLNEAYIIRKHFFGKKVKLNMILNAKSGICSEDCGYCGQSVKMKEKQRYALVEPDKIKAGAQVATENHIGTYCIVMSGRGPTNREVDHICETVHDIKVLHPQLKICACLGLTNEEQAEKLKEAGVDRYNHNLNTSERYHNEVVTTHTYEDRVRTVEIMKANHISPCSGVICGMGETNEDIIDMAFALREIDADSIPINFLHPIKGTKFGGLDLLSPMKCLRIIAMFRLINPSKEIRIAGGREVNLRSLQAIALKAANSIFVGDYLITGGQPNELDYQMIEDLGFEIDG
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RUTF_VARPS
Sequence: MLPNAMASNHVMPSGAPPVLPKADYRNAMARLGAAVNIITTDGPAGRAGFTASAVCSVTDEPPMLLVCLNRSASVYPAFTANGVLCVNVLAAGHQALSGLFGGKTPMDERFAAGRWSRKATGSPVLEDAAASFDCRVVQATSAGTHDVLFCEALAIAIGGAAQSLIYFDRRYHEIAAPPH
What is the function of this protein?
Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.
What are the official names of this protein?
FMN reductase (NADH) RutF, FMN reductase, NADH-flavin reductase RutF, NADH:flavin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
Protein: XGPT_DESPS
Sequence: MSDQYKRTYPISWDQLHRDSKALAWRLLDKDFFKGIIAITRGGMVPAAIIARELDIHLIDTICISSYDWKEKKGEADILKGFDGDGEGWLLIDDLVDTGRTAEVVKNLIPKAHFATVYAKPSGRPLVDTFVTEVSQDTWILFPWDTESQFAAPLIGREQR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NEP_I80AD
Sequence: MDSNTTSSFQDILVRMSKMQLESSSGDLNGMITQFESLKLYRDLLGEAVMRMGDLHLLQSRNGKWREQLSQKFEEIRWLIEEVRHRLKNTESSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: OBG_RHIWR
Sequence: MHFLDQAKIFIRSGAGGPGAVSFRREKFIEYGGPDGGHGGKGGDIIFEAVPGLNTLIDFRYTQHFKAQRGHGGAGSNRTGAGGEDLLIKVPVGTQILSEDREQVLADFTVPGQRQVFLRGGDGGRGNASYKTSTNRAPRQHGTGWPAEEMWVWLRLKLLADCGLVGLPNAGKSTFINAVSNAKAKVGAYPFTTIRPQLGVATHKGREFVVADIPGLIEGAAEGAGIGDRFLGHIERCRVLLHLVDASGDDPVGAYEIVRGELDAYGAGLADKPQVLALNKIDAVDAKTLDKLAKKLAKLGGGEVMRLSGASGEGLPAVLDKIIEILGPAPETTAANENDEPWSPI
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN750_XENLA
Sequence: MSLMKERKPKKPHYIPRPPGKPFKYKCFQCPFTCNEKSHLFNHMKYGLCKNSITVVTDQDRIIKNPKVNSMDQNQTSNEPFAKSSVPAINSSLESKMLHSVAREEAKENLDLKNEPKSHAEKTTVSKEFTLSPPVAISQINKPPSLDGVMRPSAFIPVGEHRVKKGAENRTIPELTSISAEPAKGVHSIKSAFHSLPTPWKSGLVSPDFSQKSSIPRYIRPMISEYPPQFYSEAGLPAVFSPYLFPQTECENPMLSIYSTPDQRPYLPHPLQPSGLPLPKPINAPFEHYRLLQQFQQNPQLHYGFYRPTEHPYFSYGLKVPPAPGLSKEHTSQSMDSPTFIYPSSHPSRLYPLEGFQKLFEIQKETPPVLAKNLDSKSDSESVKMSPRAGSAATGSPERPSPTNFTQSSQGHEGIFDLSTKSISTSDKIGKDFTSGKAMRKSTDSQTIISRENSPSFGNDGVQSHSEGITVTDDAVHDDTIAPLNLSKKSEVESRDIVDTVNNSDFTNERVGFMEMQDLPLNLSVKDSGSNHNTLCADERVLLPRQSTSPPVYQAIQTTDNRAPTTTGIHSLGIIENCDEQKQSAAVALCQLATSSPGVPPRGTEDEFPEKETVVPEQVQPRSPAAQETETDVGARGQKRTNSKELGKSQSSTKKQKAVDSGRMFTLRKRPRVS
What is the function of this protein?
Transcription factor involved in epidermis differentiation.
What are the official names of this protein?
Zinc finger protein 750.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRC_SHESM
Sequence: MTTLTITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALAYYDRIKAQVPAGSQFEPLMVLYLTDKTSPEEIRKAKASGKIVAAKLYPAGATTNSDSGVTDLKNIYPALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIENILSKIVADFPKLKIVLEHITTKDAVDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLGAAASGNKKFFLGTDSAPHAKDRKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNGPDFYNLPRNSDTITLVKKSWDVPVSYPLGDNNVVPIRAGEQIDWQVE
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: RS16_PROM2
Sequence: MIKLRLKRFGKKKEASFRIVACNSTSRRDGRPLQELGFYNPRTKETRLDTEALRTRLTQGAQPTDVVRTLLEKGGLLEKIERPSIAIGKAKLEKEKKAKAKTKEEENEGSKTESGSNEAES
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: CHEB1_SHESM
Sequence: MAIKVLVVDDSSFFRRRVSEIVNQDPELEVIATASNGAEAVKMAAELNPQVITMDIEMPVMDGITAVREIMAKCPTPILMFSSLTHDGAKATLDALDAGALDFLPKRFEDIATNKDDAILLLQQRVKALGRRRIFRPVVRPTTPTPPPRSSASSVLGGVSTHTQPAPVRSSHAASIRPSGKQYKLLLIGTSTGGPVALQKILTQFPANYPHPILLIQHMPAAFTPAFANRLNGLCKIEVKEAANGDVLRPGCAYLAPGGMQMMVERTGVTGRVKVLAGSAEMNYKPCVDITFASASKAFGGDVLAVVLTGMGADGREGARMLKSAGATIWAQDEASCVVYGMPQAVASAGIATQSISLDNMAESILKESARG
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 1.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_STRSV
Sequence: MITKPDKNKIRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQVIDDVAGVTLASASTLDKEVSKGTKTEQAVVVGKLVAERAVAKGISEVVFDRGGYLYHGRVKALADAARENGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: UXAC_ECOBW
Sequence: MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHYKWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDPIDSLEHHAEIAKDGSFTIKVLPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHALDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGALRNNNLRQFKLLGPDVGFDSINDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: NUF2_CAEEL
Sequence: MSNVVLIVYDPRMISKYLGQKLHMGLVADDIIKPTAEIAQQIFANFVRLVLNVSESSLTTLPLSANCDYDPELHKKSIPIIILFQCMKAFIKDNSGNKLDLTMCDLVTPAKHEHRFRKLTSFLVDFLKLHELATPAFNEISEEFSDRKFEMEKIREELLEAEKKKNDLLAKQSIRKRHEHELINEQSNAKAELKNVVNEYTETRQINEELDKQKEEAILHIQALEKEMLTGKKTIEHLNEEVLTSPEQLKQEMEERKRHIEELRDCLESSKKGLQAKLEAREICINSEKNVPVIIEKIHQWTEVREVIIDLIDVESENLRKLKEMEEQLDFMMKEMETAQKRLVEQSETHEQLRIEHTQKSEERQRRIEEITEQIANLKTSQPDVSQEIAKKKQELLALKNAHSETISQITNSCQDAVAKFAKLNAMFKETQKVAFEKNTAAAREMERLKSSLTGRLLSDYTFGSSTIDAGENTENCDPQPNDSSFSVFK
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity (PubMed:11402066, PubMed:14522947, PubMed:15371539).  The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).
What are the official names of this protein?
Kinetochore protein Nuf2 homolog, CeNuf2, Kinetochore protein him-10, Protein high incidence of males 10.
What is the protein family that this protein belongs to?
Belongs to the NUF2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores.
Protein: PASD1_HUMAN
Sequence: MKMRGEKRRDKVNPKSSQRKLNWIPSFPTYDYFNQVTLQLLDGFMITLSTDGVIICVAENISSLLGHLPAEIVGKKLLSLLPDEEKDEVYQKIILKFPLLNSETHIEFCCHLKRGNVEHGDSSAYENVKFIVNVRDICNEFPVVFSGLFSSHLCADFAACVPQEDRLYLVGNVCILRTQLLQQLYTSKAVSDEAVLTQDSDEEPFVGELSSSQGQRGHTSMKAVYVEPAAAAAAAAISDDQIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTMPESPALSLQDFRGEPEVNPLYRADPVDLEFSVDQVDSVDQEGPMDQQDPENPVAPLDQAGLMDPVDPEDSVDLGAAGASAQPLQPSSPVAYDIISQELELMKKLKEQLEERTWLLHDAIQNQQNALELMMDHLQKQPNTLRHVVIPDLQSSEAVPKKQQKQHAGQVKRPLPHPKDVKCFCGLSLSNSLKNTGELQEPCVAFNQQQLVQQEQHLKEQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQGQMLQKEPEEEQQKQQLQEQPLKHNVIVGNERVQICLQNPRDVSVPLCNHPVRFLQAQPIVPVQRAAEQQPSGFYQDENCGQQEDESQSFYPEAYQGPPVNQLPLIDTSNSEAISSSSIPQFPITSDSTISTLETPQDYIRLWQELSDSLGPVVQVNTWSCDEQGTLHGQPTYHQVQVSEVGVEGPPDPQAFQGPAAYQPDQMRSAEQTRLMPAEQRDSNKPC
What is the function of this protein?
Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801).  Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801).  Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).
What are the official names of this protein?
Circadian clock protein PASD1, Cancer/testis antigen 63, CT63, OX-TES-1, PAS domain-containing protein 1.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
Protein: BIC2_ARATH
Sequence: MKNTNLPEETKEPISPGSSHRKQNKTGTKTCFPETTVLSGRDRLKRHREEVAGKVPIPDSWGKEGLLMGWMDFSTFDAAFTSSQIVSARAALMADSGDDAGARGSRPQRLRVESSC
What is the function of this protein?
Regulates the blue-light dependent dimerization of CRY2 and formation of photobodies.  Inhibits CRY phosphorylation.
What are the official names of this protein?
Protein BIC2, BLUE-LIGHT INHIBITOR OF CRYPTOCHROMES 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: FEN1_YEAS1
Sequence: MGIKGLNAIISEHVPSAIRKSDIKSFFGRKVAIDASMSLYQFLIAVRQQDGGQLTNEAGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPDLKSHELTKRSSRRVETEKKLAEATTELEKMKQERRLVKVSKEHNEEAQKLLGLMGIPYIIAPTEAEAQCAELAKKGKVYAAASEDMDTLCYRTPFLLRHLTFSETKKEPIHEIDTELVLRGLDLTIEQFVDLCIMLGCDYCESIRGVGPVTALKLIKTHGSIEKIVEFIESGESNNTKWKIPEDWPYKQARMLFLDPEVIDGNEINLKWSPPKEKELIEYLCDDKKFSEERVKSGISRLKKGLKSGIQGRLDGFFQVVPKTKEQLAAAAKRAQENKKLNKNKNKVTKGRR
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: RS16_NITWN
Sequence: MPVVIRLARAGTKKRPVYHVVAADSRYPRDGRFIERLGHFNPLMPKDNADRLKLDLDKVKAWLAKGAQPSDRVARFLDAAGVKKRTPRNNPVKAVPRKERKAQAEAAAKS
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.