PharMolix/UniProtQA huggingface dataset:
Protein: ST7L_RAT
Sequence: MADGDYFAEAARAVGCPHAPVPGLGLGPPLGWKERLKAGLANSGSTLWFLAGLGLLYALRVPLRLCDNVTAVTGFLSSLTPKFYVALTGTSSLISGLIFIFEWWYFHKHGTSFIEQVSISHLRPLMGGTESSISEPGSPANSRESETLRHHHLSECKVWRNPLNLFRGAEYRRYTWVTGKEPLTYYDMNLSAQDHQTFFTCETDFLRPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALRAGEIIYRRSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYADVQAVLAKYDDISLPKSAAICYTAALLKTRTVSDKFSPETAFRKGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPFFIHFTAGLCSSTAMIALLTHQFPEVMGVFAKAVSMISRTCVEYL
What are the official names of this protein?
Suppressor of tumorigenicity 7 protein-like.
What is the protein family that this protein belongs to?
Belongs to the ST7 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL5_STRP4
Sequence: MANRLKEKYLNEVVPALTEQFNYSSVMAVPKVDKIVLNMGVGEAVSNAKSLEKAAEELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDDVDKTRGLDIVIVTTANTDEESRALLTGLGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: CYB_ASPTN
Sequence: MRILKSHPLLKILNSYLIDSPQPSNISYLWNFGSLLGLCLGIQIVTGVTLAMHYTPSVLEAFNSVEHIMRDVNNGWLVRYLHSNTASAFFFLVYLHIGRGLYYGSYKSPRTLTWAIGTVILIVMMATAFLGYVLPYGQMSLWGATVITNLMSAIPWIGQDIVEFIWGGFSVNNATLNRFFALHFLLPFVLAALVIMHLIAMHDTVGSGNPLGISGNYDRLPFAPYFVFKDLVTIFIFFIVLSIFVFFMPNALGDSENYVMANPMQTPPAIVPEWYLLPFYAILRSIPNKLLGVIAMFAAILALMVMPITDLSKLRGVQFRPLSKVAFYVFVANFLILMQIGAKHVETPFIEFGQISTVLYFAHFFVIVPVVSLIENSLVELTTKK
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MIAB_FERNB
Sequence: MKVHIFTYGCQMNENDSEIVKQLLKDEGIELTDDENDADVVILNTCAVRKKSEEKVYSHIGKLRKKGKKIGIMGCVAEKEKENLFKRGVSFVIGTRALTKVPDAVLNAKNGNKQIYLEDTLDEIEYHKVETRSSNHHAWVTIIHGCDRFCTYCIVPYTRGREKSRPIDEVLKEVESLSQRGYKEFTFLGQNVDAYGKDLRDGTSLAKLLKLASQIDNVKRLWFLTSYPTDFSLEIPKVMLESEKVARSIHLPVQHGSDKILKAMNRRYTRQEYIDLINEIRKIVPDASISSDIIVGFPGENDEDFEATVELVKLLKFERLNLAVYSPREGTVAWKYLKDDVPYQVKVRRMSYLLNLQKTINKELNKSYLGKEVEVIVEAQAKNGLFYGRDIRNKIISFEANPESIGKNVIVKVNKISAGPLYGEIKKILD
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMP1_MOUSE
Sequence: MKTVILLVFLWGLSCALPVARYHNTESESSEERTGDLAGSPPPPTNSESSEESQASPEGQANSDHTDSSESGEELGYDRGQYRPAGGLSKSTGTGADKEDDEDDSGDDTFGDEDNDLGPEEGQWGGPSKLDSDEDSTDTTQSSEDSTSQENSAQDTPSDSKDHDSEDEADSRPEAGDSTQDSESEEQRVGGGSEGESSHGDGSEFDDEGMQSDDPESTRSDRGHARMSSAGIRSEESKGDHEPTSTQDSDDSQSVEFSSRKSFRRSHVSEEDYRGELTDSNSRETQSDSTEDTASKEESRSESQEDTAESQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVTSESRGDNPDNTSQAGDQEDSESSEEDSLNTFSSSESQSTEEQADSESNESLSLSEESQESAQDGDSSSQEGLQSQSASTESRSQESQSEQDSRSEEDSDSQDSSRSKEESNSTGSASSSEEDIRPKNMEADSRKLIVDAYHNKPIGDQDDNDCQDGY
What is the function of this protein?
May have a dual function during osteoblast differentiation.  In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin.  During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).
What are the official names of this protein?
Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, AG1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity).
Protein: ACDH1_METPP
Sequence: MKKIKCALIGPGNIGTDLLAKLQRSPVLEPVWMVGIDPGSDGLKRARDAGLKTTAEGVDGLLPHVKADGVQIAFDATSAYVHAENSRKLNALGVMMIDLTPAAIGPFCVPPVNLKQHLGRREMNVNMVTCGGQATIPMVAAVSQVQAVAYGEIVATVSSRSVGPGTRKNIDEFTRTTAGAVEKVGGAKKGKAIIIINPAEPPLIMRDTVHCLTVDEPDRDRITASIHQMIREVQKYVPGYKLVNGPVFDGKRVSVFMEVEGLGDYLPKYAGNLDIMTAAAARTAEMFAEELIAGTLKLEAVPA
What are the official names of this protein?
Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase [acetylating] 1.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: MSHD_CATAD
Sequence: MTGISIGVVRRPNEADVATIRSLAEAAERADGVAPLPEQVLLHLKRSGDADADADTDAWHFVARRLSPQGSELTGYAFLDKSNAEEGPTAEVVVLPDARRQGVGGALLDALRMKVRRGDKPIRVWSHGALPAAAALAAKRGLEPVRELWVMSRPLADVPPAPTPPDGIRIATFRPGVDDEAWVEVNARAFAHHPEQGSMTVQDLRDRMAEPWFDPEGFFLAWRGAKLAGFHWTKVHDHSAYGDGPVGEVYVVGLDPAEQGHGLGRTLTEVGLRHLHDRGLGEVILYVEADNTPAVAVYTKLGFTRRSADVMYQL
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: ILVC_SYNJA
Sequence: MARLYYDTDANLDLLDGKTVAIIGYGSQGHAHALNLRDSGVNVLVGLYPGSPSWPKAERDGLTVKTVADAAAAADWVMILLPDEVQKTVFQSEIRPHLKPGKVLLFAHGFNIHFGQIQPPPDIDVIMVAPKGPGHLVRRTYLEGQGVPCLFAVYQDASGMARERAMAYAKAIGGTRAGILETSFREETETDLFGEQVVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLIVEGGLEKMRHSISNTAEYGDYTRGPRIITEQTRAEMKRILSEIQSGQFAREFVLENQAGKPVLTAMRRREAEHPIEKVGKELRAMFSWLKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: IF1C_TETOB
Sequence: MNQLKKSFSPTEGKKDQNNLINDPQKNKQKKQKKLVDMEGLVTHNLSNGKFRLKLENGVEVIGHLSGKIRQNRIKIVVGDKVTVELSPYDLTKGRITYRHR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HRCA_RHOP2
Sequence: MAHHEPIGLIAPNTGLAQLNERSRDIFRQIVESYLATGEPVGSRNISRLISMPLSPASVRNVMADLEQLGLIYAPHTSAGRLPTELGLRFFVDALMQVGDLTEPERQSIQAQLSSVGRAQTVEAALGEALTRLSGLTRAAAVVLTAKSNVRLKHLEFVRLEPERALVILVAEDGQVENRVLALPPGVPSSALTEASNFLNARIRGRTLAEARLELETMLSQDRTELDQLTQKVISAGIASWSGGDGEDRQLIVRGHANLLEDLHAMEDLERVRRLFDDLETKRGVVDLLGRAESAEGVRIFIGSENKLFSLSGSSTIIAPYSDGAGHIVGVLGVIGPTRLNYARVIPMVDYTARIVSQMLGG
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: YTFE_SHIDS
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVEVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMDHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMC_PSEAB
Sequence: MDPRSEVLLRQRHLFATPLLLAGLPADDLLAELPQAQGWSWHAGEQAQLDARFPDRSRFDTRAPTGAWTSAVLFLPKSRELTDYLLASLAARLPGGELFLVGEKRGGIERASKQLAAYGKPRKLDSARHCQLWQVRIEQAPAEPDLHALAQRYSLPLADGELQVVSLPGVFSHGRLDRGSALLLGQLQALPGGHLLDFGCGAGVLGAVLKRRYPASRLTLLDVDAFAVESSRLTLAANGLDGEVIAADGIDGAPRELAAIVSNPPFHQGVHTDYQASERLLQRAAEHLAPGGELRLVANSFLKYPPLIERHLGPCRTLAEGDGFRIYSARRS
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_SYMTH
Sequence: MQKGILGKKLGMTQIFAPDGKIIPVTVVEAGPCVVVQKKTTATDGYNAVQLGFGEIRETLVNKPLKGHFEKHQVKATRYLREFRLDDVESLNVGDVIKADIFAEGELVDVTGISRGKGFAGGVKRWNFNRGPSSHGSKYHRRPGSLGQRRWARVPKGRKLPGRLGGERVTVLGLRVVKVDPEKNLILIKGAVPGAKGSLITIRDSVKAARAKAKAQ
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: FOX5_ARATH
Sequence: MKEALSILCLALLVSVSEAEVTKPNSENFIECLRYRTSSENPITDSISIADNTTTFLSSYLSYTKNKRYSSPNFKKLLAIVAAKHVSHVQATVVCAKTNGIQLRIRSGGHDLEGLSYRSSVPFVILDMFNLRSITVNVLSKKAWVQAGATLGELYVKINEASQTLAFPAGVCPTVGVGGHISGGGYGNLMRKFGITVDHVSDAQLIDVNGKLLNRASMGEDLFWAIRGGGGASFGVILSWKINLVKVPKILTVFKVNKTLEQGGTDVLYKWQLVATKFPEDLFMRAWPQIINGAERGDRTIAVVFYAQFLGPADKLLAIMNQRLPELGLRREDCHEMSWFNTTLFWADYPAGTPKSVLLDRPTNPGFFKSKSDYVKKPIPKEGLEKLWKTMFKFNNIVWMQFNPYGGVMDQIPSTATAFPHRKGNMFKVQYSTTWLAANATEISLSMMKELYKVAEPYVSSNPREAFFNYRDIDIGSNPSDETNVDEAKIYGYKYFLGNLKRLMQVKAKYDPENFFKNEQSIPPVRVIE
What is the function of this protein?
Probable flavin-dependent oxidoreductase.
What are the official names of this protein?
Berberine bridge enzyme-like 7, AtBBE-like 7, Flavin-dependent oxidoreductase FOX5.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: LFTR_PSEMY
Sequence: MLTWLQRDSFQFPPLAKAMREPNGLLAAGGDLSAERLISAYRHGCFPWFQDGQPILWWSPDPRTVLFPQELHISRSLAKLLRQQRYRVTFDQDFAAVIAACAAPRAYADGTWITRGMQEAYRQLHQRGIAHSVEVWQGEQLVGGLYGLAIGQLFFGESMFSRADNASKVGFATLVGKLQEWGFVLIDCQMPTQHLHSFGARAIPRATFADYLQRHLNLPSRADWLA
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JZ11D_CHIGU
Sequence: MKASVLITLAVLGVMFVWASAAELEERGSDQRDSPAWLKSMERIFQSEERECRKMFGGCSVDSDCCAHLGCKPTLKYCAWDGTFGK
What is the function of this protein?
This toxin acts as a voltage-dependent gating-modifier (PubMed:25240294).  It inhibits the sodium conductance (IC(50)=124 nM) and slows the fast inactivation (EC(50)=1180 nM) of Nav1. 5/SCN5A (PubMed:17176080, PubMed:25240294).  It significantly shifts the activation to more depolarized voltages and decreases the deactivation of Nav1. 5 currents upon extreme depolarization, but only slightly affects voltage-dependence of steady-state inactivation (PubMed:17176080, PubMed:25240294).  In addition, this toxin causes an approximately five-fold decrease in the rate of recovery from inactivation and an approximately 1. 9-fold reduction in the closed-state inactivation rate (PubMed:25240294).  This toxin integrates the functions of site 3 toxins (alpha-scorpion toxins) with site 4 toxins (beta-scorpion and spider toxins) by targeting multiple sites on Nav1. 5 (PubMed:25240294).  Also shows inhibition of voltage-gated potassium channels (5 uM completely inhibits Kv2. 1/KCNB1, whereas 5 uM moderately inhibits Kv4. 2/KCND2 Kv4. 1/KCND1 channels) (PubMed:17176080).
What are the official names of this protein?
Kappa-theraphotoxin-Cg1a 4, Kappa-TRTX-Cg1a, Jingzhaotoxin-11.4, JZTX-11.4, Jingzhaotoxin-XI.4, JZTX-XI.4, Peptide F4-13.64.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 28 (Jztx-11) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MED30_DROME
Sequence: MWKYGQNQGNQGPSSGGGGGGGPNMMPMGGFGMQHGNMQQMHMSPQHQQQQQQMGMMGGPGSMQMNPQGPGGPGGLMPGMSPQHQMQQQQQQQMMQQQMMVPQQGVGVGVGMGGGVGMGGGGVVPQQQQQQPQQNMPQQNIPQQQQQLNPVAGIPPGGAGGSNNMLAISQQNPHKEINIVQLSRLGQETVQDIASRFQEVFASLKGIQPTSHRENSSEKKVQEYFRTIRLLFKRVRIIYEKCNDAGMDYMSAESLIPYRDEPEPRIEPSLCDEYRKVLQENHELIETVKLKNRQLREIIDRTRIIIWEINTMLAMRRS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 30, Mediator complex subunit 30, dMED20, dTRAP25.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 30 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ADA15_MOUSE
Sequence: MRLALLWALGLLGAGSPRPSPPLPNIGGTEEEQQASPERTLSGSMESRVVQDSPPMSLADVLQTGLPEALRISLELDSESHVLELLQNRDLIPGRPTLVWYQPDGTRMVSEGYSLENCCYRGRVQGHPSSWVSLCACSGIRGLIVLSPERGYTLELGPGDLQRPVISRIQDHLLLGHTCAPSWHASVPTRAGPDLLLEQHHAHRLKRDVVTETKIVELVIVADNSEVRKYPDFQQLLNRTLEAALLLDTFFQPLNVRVALVGLEAWTQHNLIEMSSNPAVLLDNFLRWRRTDLLPRLPHDSAQLVTVTSFSGPMVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDSPGHSCPCPGPAPAKSCIMEASTDFLPGLNFSNCSRQALEKALLEGMGSCLFERQPSLAPMSSLCGNMFVDPGEQCDCGFPDECTDPCCDHFTCQLRPGAQCASDGPCCQNCKLHPAGWLCRPPTDDCDLPEFCPGDSSQCPSDIRLGDGEPCASGEAVCMHGRCASYARQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRSPGGSYMPCAPRDVMCGQLQCQWGRSQPLLGSVQDRLSEVLEANGTQLNCSWVDLDLGNDVAQPLLALPGTACGPGLVCIGHRCQPVDLLGAQECRRKCHGHGVCDSSGHCRCEEGWAPPDCMTQLKATSSLTTGLLLSLLLLLVLVLLGASYWHRARLHQRLCQLKGSSCQYRAPQSCPPERPGPPQRAQQMTGTKQASVVSFPVPPSRPLPPNPVPKKLQAALADRSNPPTRPLPADPVVRRPKSQGPTKPPPPRKPLPANPQGQHPPGDLPGPGDGSLPLVVPSRPAPPPPAASSLYL
What is the function of this protein?
Active metalloproteinase with gelatinolytic and collagenolytic activity.  Plays a role in the wound healing process.  Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation.  Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells.  Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation.  Cleaves E-cadherin in response to growth factor deprivation.  Plays a role in glomerular cell migration (By similarity).  Plays a role in pathological neovascularization.  May play a role in cartilage remodeling.  May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction.  May play a role in sperm-egg binding through its disintegrin domain.  Interactions with egg membrane could be mediated via binding between the disintegrin-like domain to one or more integrin receptors on the egg.
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 15, ADAM 15, AD56, Metalloprotease RGD disintegrin protein, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, MDC-15, Metargidin.
What are the subcellular locations of this protein?
Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed.
Protein: RL20_LISIN
Sequence: MPRVKGGTVTRKRRKKIVKLAKGYYGSKHLLFKVANQAVMKSYQYAYRDRRQKKRDFRRLWIARINAAARMQDLSYSKLMHGLKLAGIDINRKMLADLAVNDIASFNTLADSAKKALAK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: FTSA_RHIRD
Sequence: MSFFGSSHFGLPRLKPLSSKRSHIVSVLDIGSTKVVCMIGRLTPRQESEILPGRTHKVEIIGIGHQRSRGVKSGVIADLDALEGVIRLSVDAAERMAGLTVDSLIVNVSAGRLASDIYTASIDLGGQEVEASDLRKVLVAASQQSMRQDRAILHSLPTGYSLDGERGIRDPLSMYGDLLGVDMHVVTVERTALKNLELCVNRAHLSVEGMVATPYASGLAALVDDEVELGCAAIDMGGGTTTISVFAEGRLIHTDAIGLGGHHVTTDLARGLSTRIEDAERLKVVHGSALLNGADERDMISIPPIGEDDRDQPSQVSRALVTRIVRARIEETLELIRDRIQKSGFSPIVGKRVVLTGGASQLTGLPETARRILARNVRIGRPMGVAGLPVAAKGPAFSTACGLMIYPQVADIEIHAAQGGMFSPFGNGSGRIARVGQWLKESF
What is the function of this protein?
Cell division protein that is involved in the assembly of the Z ring.  May serve as a membrane anchor for the Z ring.
What are the official names of this protein?
Cell division protein FtsA.
What is the protein family that this protein belongs to?
Belongs to the FtsA/MreB family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Protein: SEPT4_MOUSE
Sequence: MDHSLGWQGNSVPEDGTEAGIKHFLEDSSDDAELSKFVKDFPGSEPYHSAESKTRVARPQILEPRPQSPDLCDDDVEFRGSLWPQPSDSQQYFSAPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH
What is the function of this protein?
Filament-forming cytoskeletal GTPase (Probable).  Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (PubMed:30389919).  May also play a role in the regulation of cell fate in the intestine (PubMed:30389919).  Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (PubMed:20952537).  Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (PubMed:23788729).  Plays an important role in male fertility and sperm motility (PubMed:15737930, PubMed:15737931).  During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (PubMed:15737930, PubMed:15737931).  Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (PubMed:20181826).  Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (PubMed:17296554).
What are the official names of this protein?
Septin-4, Bradeion beta, Brain protein H5, CE5B3 beta, Cell division control-related protein 2, hCDCREL-2, Peanut-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle. Cell projection, axon. Cell projection, dendrite. Perikaryon. Synapse. Note=Found in the sperm annulus, a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum (PubMed:15737930, PubMed:15737931, PubMed:27811987). In platelets, found in areas surrounding alpha-granules (By similarity). Expressed and colocalized with SLC6A3 and SNCA in axon terminals, especially at the varicosities (PubMed:17296554). SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion. Cytoplasm, cytosol. Note=In retinoic acid-treated P19 cells, found first in the mitochondria and at later times, as neuronal differentiation proceeds, in the cytosol.