PharMolix/UniProtQA huggingface dataset:
Protein: IOD3_MOUSE
Sequence: MPRQAASRLVVGEGEGPPGASGPAATMLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGFQSQRILDYAQGTRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPHRF
What is the function of this protein?
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine).  RT3 and T2 are inactive metabolites.  May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones.  Can regulate circulating fetal thyroid hormone concentrations throughout gestation.  Essential role for regulation of thyroid hormone inactivation during embryological development.
What are the official names of this protein?
Thyroxine 5-deiodinase, 5DIII, DIOIII, Type 3 DI, Type III iodothyronine deiodinase.
What is the protein family that this protein belongs to?
Belongs to the iodothyronine deiodinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Protein: NRDR_DINSH
Sequence: MRCPFCGNVDTQVKDSRPAEDHVAIRRRRFCPACGGRFTTYERVQLRDLVVIKSSGKREDFDRDKLERSIRIAMQKRPVEPDRLDQMISGIVRRLESMGETDIPSATIGEIVMEALARIDTVGYVRFASVYKNFQAADDFDKFVSELRPPTGKDS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: MUTS_BORPA
Sequence: MSSTPKQTTGDALAGHTPMMQQYLRLKAEAGPLLLFYRMGDFYEMFYEDAERAARLLNLTLTKRGNSNGTPIPMAGIPVHAMEQYLARLVALGESVAICEQIGDPAAAKGPVERRIVRIVTPGTLTDEALLPAKADRALAAVCVTGKREPRAGLAWLNLASGAFHVTECAPGQLESELHRIAPAELIQAESAELHMAFEGARTRVPDWHFEADGARAQLLAHFKTDSLGGFDVEDMPAAVCAAGALLRYAARTQSQALAHVQTIAAERPGQYVLLDPVTRRNLELTQTLSGEESPTLFSLLDGCRTPMGSRLLRRWLHHPLRENEPVLARQHAIATMLTVRQEGEQAFAAAGLLETLRDALNAFPDIERIAARVALRSVRPRELASLRDALVALPALHASLAPLSGSPRARELAAQLAMPPDIGELLARAVASEPAVAIRDGGVIAAGFDSELDELRALATDGGDFLVQLEARERERTGIGNLRVEFNRVHGFYIEVSKGQTDKVPEDYRRRQTLKNAERYITPELKTWEDRVLSAQDRSLAREKWLYEQLLDALAQYVRPLSQCASALAELDTLAALAEHARRHDWVAPELIDGAEIDIEAGRHPVVERAIERFTPNGCRLDQTRRMLLITGPNMGGKSTYMRQVALIALLARTGSFVPATRARVGRLDRIFTRIGAADDLAGGRSTFMMEMTEAAAILAASTPASLVLMDEIGRGTSTYDGLALAWAIAYRLLTHNRALTLFATHYFELTRLPAEQPTAANVHLAAAESAGGIVFLHEVREGPASRSYGIQVAQRAGVPAAVIRQASRELERLEAQGAPTPQLGLFAAALDADVQSQAMTEQAEDAAALAQLRDQLAAIDPDSLTPREALDALYRLKQHLT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: KDPC_BACFN
Sequence: MKTLLKSIKITLVFCVFFSVFYILVLWLFAQVAGPNRGNAEVVTLNGKVVGAANVGQTFTEEKYFWGRPSCAGDGYDATSSAGSNKGPTNPEYLAEVEARIDTFLIHHPYLARKDVPAEMVTASASGLDPDITPQSAYVQVKRVAQARGMNVEEVRRVVDKAVEKPLLGIFGTEKVNVLKLNIALEELKNR
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RRF_CHLPM
Sequence: MSVREVIQKNEAKLKKSIEAFQHEIASIRTGKATTALLDRVKVEAYGQLMPLKQVGNIGVADVHTLMVQVWDKGMVGPAEKAIRDANLGLNPVAEGQSIRVSIPPLTEERRKEFVKLTRKFGEDSKVSLRNLRRDMIQEIEKLEKEKTIGEDEKNRGKKDADELLHKYEKQINELISHKEKEIMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASP_PLAFS
Sequence: MYLFIYIFFFFFFFFFFVIVQKDIEQLDIKCAHEQMNIQKQYDEKKKPLFEKRDEIIQKIPGFWANTLRKHPALSDIVPEDIDILNHLVKLDLKDNMDNNGSYKITFIFGEKAKEFMEPLTLVKHVTFDNNQEKVVECTRIKWKEGKNPIAAVTHNRSDLDNEIPKWSIFEWFTTDELQDKPDVGELIRREIWHNPLSYYLGLEEFDEFDDDFDEEFDDDDDDDDDDDDDDDDDDKDDDLDGDDDGNNDDNDD
What are the official names of this protein?
Aspartic acid-rich protein.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
Protein: UREG_BLOPB
Sequence: MLLNQYRKPLRIGVGGPVGSGKTALLEVLCKRMKDSYQLAVVTNDIYTKEDQRILIDANALSADRIVGVETGGCPHTAIREDASMNLLAVEELISKFNNLDIIFIESGGDNLSATFSPELSDLNLYVIDVAAGDKIPRKGGPGITRSDFLIINKIDLAEYVGASLEIMNRDTNLMRKGLPWSFTNLKTGHGVQSVVDFILRQRLYLQ
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_BORBZ
Sequence: MAKDIYFNEDARKSLLSGVEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKDGVSVAREIELENPFENMGAQLLKEVAIKTNDVAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGIDHAVNLAAEKIRQSAKKITTKEEIAQVASISANNDSYIGEKIAEAMDKVGKDGVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVNFDDAFILIYEKKISSIKELLPVLEKVLGTNKPLLIIAEDIEGDALAALVLNSVRGALKVCAIKSPGFGDRRKAMLEDIAVLTGGVLISEELGLTLETVEIEQLGQAKTIKVDKDNTTIINTGNKEQIKERSELIKKQIEDSTSEYDKEKLQERLAKLVGGVAVINVGAVTEVELKEKKHRVEDALSATRAAVEEGVVPGGGSTLIEVAMYLDTIDTSKLSYEEKQGFEIVKRSLEEPMRQIISNAGFEGSIYIHQIKTEKKGLGFDASSFKWVNMIESGIIDPAKVTRSALQNAASIAGLLLTTECAITDIKEEKNTSGGGGYPMDPGMGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPTN_METAC
Sequence: MKKIGIAITDPEDWTARALITAAKEKGFFPFILDLRIAEVSISSKTSEPATLFKAGEILLSDLDALIVRDVGAGAFEGVSFRFDILRELEAGGVTVMNSPEAIQNAANKYHASYLLARAGLPVPETVAVQSVEAALRAASGFGDAVIKPVFGYKGKDIARVKDGEIRFSDRKTGPGTVEEILEKLLEERGMLYIQEFIENPGRDIRAFVVGGKAIGAIYRKAAAGSWVNNLSRGGSADRCVLAEEQKEIAEKAALAVGTTFAGIDIIEGAKAQTGNENKKTEDKSTGQGSRILEVNGTPSGKGIFDAWGINPAEYILEYLQNIL
What is the function of this protein?
Catalyzes the ATP or GTP-dependent addition of one L-glutamate molecule to tetrahydromethanopterin, producing tetrahydrosarcinapterin.
What are the official names of this protein?
Tetrahydromethanopterin:alpha-L-glutamate ligase, H(4)MPT:alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family. MptN subfamily.
Protein: DEF_ECO27
Sequence: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSPLKQQRIRQKVEKLDRLKARA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: FMT_PSEPF
Sequence: MTEPLRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSPVKQLALENNIQVLQPPTLRNADAQAELAALKPDLMVVVAYGLILPQAVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDTGGSLHDRLAEMGPPAVVQAIAGLAAGTLEGEVQNDELATYAHKLNKDEARIDWSRPAVELERLVRAFNPWPITHSTLNGEALKVLAATLAEGKGAPGTILGASKDGLIVACGEQALCLTRLQLPGGKALNFSDLFNSRREKFATGIVLGAAVDAQ
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: CLPX_YEAST
Sequence: MLKSASQNFFRAYSSRIGRYAATASGKLAQSRLSNIPTPKALKKFLDEYIVGQEIGKKVLSVAVYNHYLRINDKQKKGELQRQRELMEREKIADDRDEPIFSGNSESKAGWRNLQRQFNLAGREVDEDLELSKSNVLVVGPSGSGKTLLATTLAKILNVPIAITDCTQLTQAGYIGEDVEVCIERLLVNAEFDVARAEKGIIVLDEIDKLAKPAASIGTKDVSGEGVQQSLLKIIEGHKVEITVKRPVKHDIDGQKNQTTTKKDEVFVVDTSNILFMIMGAFVGLDKHIVKRIEDMKKIQKAGESVESSNSKEVEKERAKKFRFSNTLEQVELDNGKKVCALDLTTPTDLVSFGLIPELIGRVPIITALQPLQRDDLFHILKEPKNALLDQYEYIFKQFGVRLCVTQKALKKVAQFALKEGTGARGLRGIMERLLLNVNYDCPGSNIAYVLIDEATVDSLQETEHSLASQVDVKYYSGDEKDSLIRDVSEEDKKLGVMLEKELGHSANIHTPTIPKRSLT
What is the function of this protein?
ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase (HEM1), thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis.  Up-regulates heme biosynthesis.
What are the official names of this protein?
ATP-dependent clpX-like chaperone, mitochondrial, mtClpX, ATP-dependent unfoldase ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ILVD_CLAMS
Sequence: MPEIDMKPRSRDVTDGIEATSSRGMLRAVGMGDEDWEKPQIGVASSWNEVTPCNLSLDRLAQGAKEGVHAGGGYPLQFGTISVSDGIAMGHEGMHFSLVSREVIADSVETVMMAERLDGSVLLAGCDKSLPGMLMAAARLDLSSVFLYAGSIAPGWVKLSDGTEKEVTIIDAFEAVGACKAGTMSQEDLTRIEKAICPGEGACGGMYTANTMASVAEALGMSLPGSAAPPSADRRRDYFAHRSGEAVVNLIAKGITARDIMTKEAFENAISVVMAFGGSTNAVLHLLAIAREAEVDLQLSDFNRIADRVPHLGDLKPFGRFVMNDVDRVGGVPVVMKALLDAGLLHGDVMTVTGRTMRENLEAMDLADLDGTVIRKMDDPIHATGGISVLHGSLAPEGAVVKTAGFDLDVFEGPARVFERERAAMDALTEGRISKGDVIVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCIGHMAPEAVDAGPVAFVRDGDRIRVDIAARTLDLLVDEAELAARREGWAPLPPRYTRGVLAKYAKLVHSAAEGAITG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: UVRB_PHOPR
Sequence: MSKVFSLSSGFSPAGDQPTAINQLLEGLDSGLAHQTLLGVTGSGKTFTIANVIAESNRPTFIMAPNKTLAAQLYGEMKEFFPDNAVEYFVSYYDYYQPEAYVPTTDTFIEKDASVNAHIEQMRLSATKALLERRDVIIIASVSAIYGLGDPDSYLKMMLHVRRGDMLNQRDILRRLAELQYTRNDVSFERGHFRVRGEVIDVFPAESEHDAIRIELFDDEVECINVFDPLTGAVLQKDLPRCTIYPKTHYVTPREKILEAIEKIKDELVVRRKQLMDSNKLVEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSGREEGEPPPTLFDYLPADGLLIIDESHVTVSQIGAMYRGDRSRKENLVEYGFRLPSALDNRPMKFEEFASLAPQTIYVSATPGKYEIEQSGNDIAEQVVRPTGLLDPIIEVRPVATQVDDLLSEIRIREVKGERVLVTTLTKRMSEDLAEYLAEHNVKVRYLHSDIDTVERVEIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLEGRAILYGDKITGSMERAIFETNRRREKQALHNKKNGITPQGLNKKVGDILELGKPSSRSRTNKAAQLNRVAESKGTYVNLSPQQLELEIQRLETEMYDLAQNLEFEKAAEARDKIHTLRQQFIMNS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y187_BRUA4
Sequence: MTDLREKKRTAFFRGHSAERFASVLLLLKGFRIVARRYRTRLGEIDLIARRGNLILIVEVKARSSLEAAHLAVTPQAMRRIEAAADLWLQRQPDHARLSLRFDLIAVLPRRWPKHVPAFFTSGNY
What are the official names of this protein?
UPF0102 protein Oant_0187.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RNH2_ECOK1
Sequence: MIEFVYPHTQLVAGVDEVGRGPLVGAVVTAAVILDPARPIAGLNDSKKLSEKRRLVLCEEIKEKALSWSLGRAEPHEIDELNILHATMLAMQRAVAGLHIAPEYVLIDGNRCPKLPMPSMAVVKGDSRVPEISAASILAKVTRDAEMAALDIVFPQYGFAQHKGYPTAFHLEKLAEHGATEHHRRSFGPVKRALGLAS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_SYNR3
Sequence: MSLEPAMTTPDVLRVEVLSEALPYIQRFRGRRVVIKYGGAAMVREDLRDAVFRDVALLASVGVEPVVVHGGGPEINQWLNRLSIEPVFQEGLRVTCPDTMDVVEMVLVGRVNKQIVNGLNRVGGRAVGLSGADGGLVQARTHGDGSLGLVGDVAQVDPSVIIPLLDQGYIPVISSVAPNHEGQPYNINADTVAGELAAAMDAEKLILLTDTPGILRDRDDPESLIDQLSLSEARELIHAGVVAGGMVPKTECCIRALAQGVRAAHILDGRVPHSLLLEVFTNSGIGTMVLGSRQQG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_CAMJE
Sequence: MNITLLKSKIHRASVTEARLDYIGSISIDEKLLQASGILEYEKVQVVNVNNGARFETYTIATQEEGVVCLNGAAARLAEVGDKVIIMSYADFNEEEAKTFKPKVVFVDENNTATKITNYEKHGAIF
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_SYNR3
Sequence: MLPLPRRQQQVLQATVQHYVDTVEPVGSRTLVRRFGLDASPATVRSAMGALEQKGLLTQPHTSAGRVPSPKGYRQFVDALLPEPGAAVVQLQRELAELSLQWAALDDLLHHLARRLADLTGLMSIITRPQRQEPRLKALRLVRSGDRLLVFLVESSAASSSLNLRLPPDSSAQLQALEHWLNDQLSKSAINWSGLPSHLQSVGAPLKQALASHNRGRNRQAEGALTTGLAGLLCQPEFQLTTSLRPLLQLVEQQPHELLNPAAATASGGVWIGQEHPHPALSGCAVVQAPYATASGGEGSVALVGPMRMAYATALAAVEAVAGTLSRLLA
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: BHE40_BOVIN
Sequence: MERIPSAQPPPTCLPKAPGLEPGDLSGMDFAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGDLSGRNVEAGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKAMDFKEKPSSLAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKSELRVEQPYFKSDHGRRFTMGERISAIKQESEEPPMKKSRMQLSDDEGPFTSTDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYQGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPTHPAIDSSALLQALKQIPPLNLETKD
What is the function of this protein?
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes.  Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop).  Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2.  Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes.  Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2.  Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity.  May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (By similarity).  Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (By similarity).  Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (By similarity).
What are the official names of this protein?
Class E basic helix-loop-helix protein 40, bHLHe40, Class B basic helix-loop-helix protein 2, bHLHb2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus (By similarity).
Protein: USP16_LOTGI
Sequence: MWCFIVFLTIFLPTLEGQYGPAVTGPSLPEELCTKDPQVSRGRFYRLKVRPSFYRRAHPLQVELYQTIHAYGPIIADAYVHVPETAKNSSTAALGIKTLGYWLPKNPDNYKISRALSCYNSVWGNDAIVANSDRELKFNLTGIWYPPTSEFDLIKRPFVKIVAYVTPDPDVRRRRWYRAESQPIRNLDYIAFQHHMRRYKAQMKAFRTQLEMFN
What are the official names of this protein?
Uncharacterized shell protein 16, LUSP-16.
Protein: TATE_SALTY
Sequence: MGEISITKLLVVAALVVLLFGTKKLRTLGGDLGTAIKGFKKAMNDEDAGVKKDVDGSVQAEKLSHKE
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatE shares overlapping functions with TatA.
What are the official names of this protein?
Probable Sec-independent protein translocase protein TatE.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family. TatE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ENGB_BURP1
Sequence: MAFLLHQARFFTTVNHLRDLPPTVQPEVAFAGRSNAGKSTAINVLCNQKRLAFASKTPGRTQHINYFSVGPAAEPVAHLVDLPGYGYAEVPGAAKAHWEQLLSSYLQTRPQLCGMILMMDARRPLTELDRRMIEWFAPTGKPIHSLLTKCDKLTRQESINALRATQKSLDAYRDAGYAGKLTVQLFSALKRTGLDDAHALIESWVRPAAADEDRAAVAE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: KDPC_SHIDS
Sequence: MSGLRPAISTFIFLLLITGGVYPLLTTVLGQWWFPWQANGSLIREGDTVRGSALIGQNFTDNGYFQGRPSATAEMPYNPQASGGSNLAVSNPELDKQIAARVAALRAANPDTSTSVPAELVTASASGLDNNITPQAAAWQIPRVAKARNLSVEQLTQLIAKYSQQPLVKYIGQPVVNIVELNLALDKLDE
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CA1D_CONTE
Sequence: FDGRNAAGNDKMSALMALTTRGCCSHPVCSAMSPICG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  This toxin inhibits alpha-3-beta-4/CHRNA3-CHRNB4 (IC(50)=3. 6-18. 38 nM), alpha-6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB2-CHRNB4) (IC(50)=33. 9-94. 1 nM), and alpha-2-beta-4/CHRNA2-CHRNB4 (IC(50)=4550 nM) nAChRs (PubMed:24200193, PubMed:28603989, PubMed:29925760).  The toxin competes with agonists in the orthosteric binding site of alpha-3-beta-4/CHRNA3-CHRNB4 and alpha-6-beta-4/CHRNA6-CHRNB4 (PubMed:30252466).
What are the official names of this protein?
Alpha-conotoxin TxID, Alpha-conotoxin TxIC.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PSD_GEOMG
Sequence: MRNSNTPIAAEGYPFIAGAVLIAVVLAVLGSKIPAFFFLAVFFGALTLFIVFFFRNPERTTPADENAVIAPADGVVIYLGPSREEHLGEEMTKISIFMSVFNVHVNRVPITGKVLDTFYIKGKFLDVRDDRATFENEQAGLIIETAKGMKMIVVQVAGLIARRIVCYAAKGDQLVRGKRYGLIRFGSRLDVYLPSETAVRVRMGDKTVAGETILGLLP
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SYV_JANMA
Sequence: MELAKSFDPADIEAFWRTEWEKRGYYTATTDADKPAFSIQLPPPNVTGTLHLGHGFNQTIMDGLTRYHRMRGFNTAWIPGTDHAGIATQIVVERQLDAQKITRHDLGREKFVEKVWEWKEKSGSTITGQIRRLGASPDWSREYFTMDEPRSKTVTEVFVRLVEQGLIYRGKRLVNWDPVLGTAVSDLEVVSEEEDGQMWNIRYPLADGSSYKFPIAFDEAGNATEWEERNFIVVATTRPETMLGDVAVAVDPTDTRYQHLVGKLLTLPLCERTIPIIADDYVDKEFGTGCVKITPAHDFNDYAVGQRHNLDKISILTLDAKINENAPAAYQGLDRFAARKQIVADLDAQGLLELVKPHKLMVPRGDRTNTVIEPMLTDQWFVAMSKPAPEGTYFPGKSITEVALEKVANGEIKMLPENWTNTYNQWLNNIQDWCISRQLWWGHQIPAWYDSEGKVYVARNEDEAKAKATAAGYNGPLTRDEDVLDTWFSSALVPFSTLGWPEETPDFKTFLPSSVLVTGFDIIFFWVARMVMMTTHFTGKVPFKTVYVHGLIRDSSGQKMSKSKGNTLDPIDLIDGINVDELVAKRTVGLMNPKQAASIEKSTRKEFPAGISAYGTDALRFTMASYASLGRNINFDLSRCEGYRNFCNKLWNATRFVLMNCEGHDCGFRDAPCAAGDCDPGGYTDFSQADRWIVSKLQRTEADIAKGFADYRFDNIAASLYQFIWDEYCDWYLEVAKVQIQTGTEAQQRATRRTLLRVLETILRLAHPVIPFITEALWQTVAPLTGYKPNPAGDSIMLQPYPEAQAGKIDEQAENWMAELKAMTDACRNLRGEMQLSPALRVPLIMEASDPTQAARLQSFAPYLQALAKLSEVNVADKLPESPAPVSIVGTAKLMLKVEIDVAAERERLSKEIARLDGEITKANSKLGNESFVARAPAQVVAQEKERVANFSATLNKLREQFAKL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.