PharMolix/UniProtQA huggingface dataset:
Protein: PROA_NOSS1
Sequence: MTTLQVASSLNDIAQQTRQAASLLAMLSTEAKNQAIAAVAQALESAKEEILQANIDDCEAATAEGIAKPLYKRLQLDEHKLRDAIAGVRDVGKLADPIGQVQIQRELDTGLVLKRITCPLGVLGIIFEARPEAAIQIISLAIKSGNGVILKCGKEAVRSCEAIVKAVKQGLSTTDVNPEVVQLLTTREETLELLRLDKYVDLIIPRGSNSFVRFVQENTRIPVLGHADGICHVYIDKSADIEKAIAVSVDAKVQYPAACNAIETLLVHQSIAAEFLPKVAQALAEREVELKGDERTLQILPEIAAATAIDWETEYSDFILSIKIVDSLTEAIAHINQYGSRHTDAIITEDVAAVKTFFGLVNSAGVFHNCSTRFADGFRYGFGAEVGISTQQMPPRGPVGLEGLVTYKYQMTGAGHIVATYTGENAKPFTHKDF
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ELP6_MOUSE
Sequence: MFPELNNLLSTTPDKTEQGTLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALVQSFSHYNIVGQKLGVSLTAARDRGQLVFLEGLKSSVEVLFHSQDEPHPLQFLREAGTGNLQSLYTFIQDTLKPADSEESPWKYPVLLVDNLSVLLSLGVGAVAVLDFMQYCRATVCCELKGNVVALVHDTEGATDEGNDTLLNGLSHQSHLILRAEGLATGFCKDVHGQLSILWRRPSRSTAQRAQSLTYQYKIQDKNVSFFAKGMSPAVL
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity).  The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).  Involved in cell migration (PubMed:22854966).
What are the official names of this protein?
Elongator complex protein 6, Protein TMEM103.
What is the protein family that this protein belongs to?
Belongs to the ELP6 family.
Protein: IER2_MOUSE
Sequence: MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSAREVYLSAKVEAHQPEFPPSRRALDPRLHPPREAEVAVEVASPEAVQPPEPMDTQEEVLRVQETPALCDPPPARVSRKRRSSSDLSDGSDAGLVPSKKARLEEVEGEATSEVPDRLQLPPAQSEGAFPNLARVLQRRFSSLLNCGPAVPPPTPPTCEAKPACRPADNMLNVLVRAVVAF
What is the function of this protein?
DNA-binding protein that seems to act as a transcription factor (By similarity).  Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity).  May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity).  Promotes cell motility, seems to stimulate tumor metastasis (By similarity).
What are the official names of this protein?
Immediate early response gene 2 protein, CHX1, Cycloheximide-induced gene protein, Growth factor-inducible immediate early protein, Proline-rich-induced protein 92, Pip92, T-lymphocyte-activated protein.
What is the protein family that this protein belongs to?
Belongs to the IER family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation.
Protein: Y288_VIBC3
Sequence: MIVTTTPNIEGKRIVRYCGVIAGEAILGANIFKDLFAGIRDIVGGRSGTYERELEKARAIALEELQQHAVALGANAVVGIDLDYETFGKANGMLMVSVSGTAVVVE
What are the official names of this protein?
UPF0145 protein VC0395_0288/VC395_A0976.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: IPO4_MOUSE
Sequence: MEPAGLEQILKELLLPDTERIRRATEQLQTILRDPAALPALFDLLATATDSQIRQFAAVLTRRRLNNRWRRLAPEQRESLKSLVLTALQKETVHSVSVSLAQLSATIFRKEGLQGWPQFMNLLQHSTHSSHSPEKEVGLLLLSVVVSSQPEAFHAHQHELLQLLNETLSDVSFPGVLFYSLRTLTAIARYVRPDDVSLARMLVPKVVTALRTLIPLDEVKACEALEALDEMLETELPIINPHLSEVLTFCLEVAKNVALGEPLRVRVLCCLTFLVKVKSKALLKNRLVPPLLHALFPLMAAEPPMGQLDPEDQDSDDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLCPHVMPMLEEALRSEDPYQRKAGFLVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQIVRNAALFALGQFSENLQPHISSYSEEVMPLLLSYLKSVPMGNTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKNPSKARTKELAVSAIGAIATAAQDSLLPYFPTIMDLLREFLLTGHEDFHLVQIQSLETLGVLARALGESMKPLAEECCQLGLGLCIHIDDPDVRRCTYSLFAALSGLMGEGLGPYLPQITTLMLLSLRSTEGIVPQYDGISSFLLFDDDSEAEEEEELMDEDMEEEGDDSEISGYSVENAFFDEKEDTCTALGEISMNTCVAFLPFMDATFDEVYKLLECPHMNVRKSAYEALGQFCCALHKASQRSSSDPSSSPVLQTSLARVMPAYMQAVKVERERPVVMAVLESLTGVLRTCGSLALQPPGRLSELCNVLKAVLQKKTACQDAEEDDDEDDDQAEYDAMLLEHAGEAIPVLAATAGGHAFAPFFATFLPLLLCKTKQSCTVAEKSFAVGTLAESIQGLGTASAQFVSRLFPVLLNNAREADPEVRSNAIFGLGVLAEHGGCPAQDHFPKLLGLLLPLLARERHDRVRDNICGALARVLMASPVGKTEPQVLATLLRALPLKEDMEEWLTIGHLFSFLHQNNPEQVVDVASELLRICSLILPDNRIPPDTKAALLLLLTFLAKQHTDSFHTALGSLPNDKAQELQAMMGLT
What is the function of this protein?
Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR.  Serves as receptor for nuclear localization signals (NLS) in cargo substrates.  Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.  Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B).  Mediates the ligand-independent nuclear import of vitamin D receptor (VDR).
What are the official names of this protein?
Importin-4, Imp4, Importin-4a, Imp4a, Ran-binding protein 4, RanBP4.
What is the protein family that this protein belongs to?
Belongs to the importin beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: QUEC_LEPBL
Sequence: MNSRKDKNSKGKNSDTKRKKSSQENDKAVVLLSGGLDSTTCLYQALADGKKIQALSFDYGQKHKIELSYAKKITRQLGISHTIQKLKPELFLGSSLTQKSLRVPKNSLGKEEIPNTYVPGRNILFLSFAVCLAEGTGSNSIYIGVNAMDYSGYPDCRPEFIKTYETAIQLGTKKGNQGSPIKIVTPLQNLSKKEIVLLGNRLQVPFHLTFSCYDPKNRKACGKCDACLLRKKGFQETGVSEK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: MATP_SALHS
Sequence: MKYQQLENLESGWKWKYLVKKHREGELITRYVEASAAQEAVNLLLALENEPVRVNVWIDRHMNPALLNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFMVWQRLAGLAQRRGKTLSETIVQLIEDAEHKEKYATQMTTLKQDLQALLGKK
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GBRB3_HUMAN
Sequence: MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).  The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750).  The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).  Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286).  Plays an important role in somatosensation and in the production of antinociception (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit beta-3, GABA(A) receptor subunit beta-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
Protein: CLPS_MYCTA
Sequence: MAVVSAPAKPGTTWQRESAPVDVTDRAWVTIVWDDPVNLMSYVTYVFQKLFGYSEPHATKLMLQVHNEGKAVVSAGSRESMEVDVSKLHAAGLWATMQQDR
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: AAKB1_HUMAN
Sequence: MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
What is the function of this protein?
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.  In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.  AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.  Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.  Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
What are the official names of this protein?
5'-AMP-activated protein kinase subunit beta-1, AMPK subunit beta-1, AMPKb.
What is the protein family that this protein belongs to?
Belongs to the 5'-AMP-activated protein kinase beta subunit family.
Protein: PSBA_NICDE
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAIEAPSTNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, 32 kDa thylakoid membrane protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: COXX_AROAE
Sequence: MSVLNTRTLTLDRHAAARRLHAFYVLTKPRVNTLIVFCAVIGMFLAVPDGLPDPKSVVAATLGIAFVAGAAAAMNCLIEAHIDARMARTRHRPLPRGELAPAETLLFAGVLGGTGLTVLYHWVNPLTMWLTLATFVGYAVVYTVLLKPRTPQNIVIGGASGAMPPVLGWAAVTGEVSADALLLFLIIFAWTPPHFWALALYRSADYARAGLPMLPVTHGPEFTRLSVLLYTCILFGVTLLPFATRMSGPLYLVCAVALGIGFLRHAWRLYADYSDAFARRTFRFSILYLFLLFAALLMDHYLPL
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL17_CHLL3
Sequence: MRKVKPARKLGRTAAHRRATLSSLSTQLILHKRIETTEAKAKETRKVVEKIITKALKGTVHAQREIFKDIRDKEAIKTLFGEVVAKVGDRPGGYTRIIKLCPRFGDAAKMAVIELVDFAEAPVAAPKAAKQDRAKRVKGSKKVTGDVAPAVAPVPSAPAETQEEAKAPESAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: KIT_CHICK
Sequence: MEGAHLAWELAHAVLLLSLIPAGGSVPHEESSLVVNKGEELRLKCNEEGPVTWNFQNSDPSAKTRISNEKEWHTKNATIRDIGRYECKSKGSIVNSFYVFVKDPNVLFLVDSLIYGKEDSDILLVCPLTDPDVLNFTLRKCDGKPLPKNMTFIPNPQKGIIIKNVQRSFKGCYQCLAKHNGVEKISEHIFLNVRPVHKALPVITLSKSYELLKEGEEFEVTCIITDVDSSVKASWISYKSAIVTSKSRNLGDYGYERKLTLNIRSVGVNDSGEFTCQAENPFGKTNATVTLKALAKGFVRLFATMNTTIDINAGQNGNLTVEYEAYPKPKEEVWMYMNETLQNSSDHYVKFKTVGNNSYTSELHLTRLKGTEGGIYTFFVSNSDASSSVTFNVYVKTKPEILTLDMLGNDILQCVATGFPAPTIYWYFCPGTEQRCLDSPTISPMDVKVSYTNSSVPSFERILVESTVNASMFKSTGTICCEASSNGDKSSVFFNFAIKEQIRTHTLFTPLLIAFGVAAGLMCIIVMILVYIYLQKPKYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLFKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHINIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICPKHEEHAEAAVYENLLHQAEPTADAVNEYMDMKPGVSYAVPPKADKKRPVKSGSYTDQDVTLSMLEDDELALDVEDLLSFSYQVAKGMSFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGILLWELFSLGSSPYPGMPVDSKFYKMIKEGYRMFSPECSPPEMYDIMKSCWDADPLQRPTFKQIVQLIEQQLSDNAPRVYANFSTPPSTQGNATDHSVRINSVGSSASSTQPLLVREDV
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.  In response to KITLG/SCF binding, KIT can activate several signaling pathways.  Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1.  Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1.  Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B.  KIT promotes activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor (By similarity).
What are the official names of this protein?
Mast/stem cell growth factor receptor Kit, SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: HHO6_ARATH
Sequence: MGSLGDELSLGSIFGRGVSMNVVAVEKVDEHVKKLEEEKRKLESCQLELPLSLQILNDAILYLKDKRCSEMETQPLLKDFISVNKPIQGERGIELLKREELMREKKFQQWKANDDHTSKIKSKLEIKRNEEKSPMLLIPKVETGLGLGLSSSSIRRKGIVASCGFTSNSMPQPPTPAVPQQPAFLKQQALRKQRRCWNPELHRRFVDALQQLGGPGVATPKQIREHMQEEGLTNDEVKSHLQKYRLHIRKPNSNAEKQSAVVLGFNLWNSSAQDEEETCEGGESLKRSNAQSDSPQGPLQLPSTTTTTGGDSSMEDVEDAKSESFQLERLRSP
What is the function of this protein?
Probable transcription factor involved in phosphate signaling in roots.
What are the official names of this protein?
Transcription factor HHO6, MYB-domain transcription factor HHO6, Protein HRS1 HOMOLOG 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATAY_ASPTN
Sequence: MYGPGTKFEKAMFYTRGPKEKQLLVNLASTTDKAVHARKRRIISHALSEASIRSYEVTILDKIQLFCKQLSDASTFGGPYKNMSRWFSYLTYDIMGQLTFSQSYDMLTKDDHHFIQPLIDSYQHSQLGTEPKLDQWGLAPLLLLRIMAENKKFRRYVDDQVNHRIALEKAGQGPPDIFKLLLEHKDKETGESMGFKELSDEAVVLIIAGRRFFSPCVNGSKRFTLNSQ
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of acetylaranotin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide-bridged cyclic dipeptide (PubMed:23586797).  The first step of acetylaranotin biosynthesis is performed by the NRPS ataP which produces diketopiperazine cyclo-L-Phe-L-Phe via the condensation of 2 phenylalanines (L-Phe) (PubMed:23586797).  The ataC domain of ataTC then catalyzes the formation of bishydroxylation of cyclo-L-Phe-L-Phe (PubMed:23586797).  The glutathione S-transferase domain ataG in ataIMG further catalyzes the conjugation of two glutathiones to the bishydroxylated intermediate (PubMed:23586797).  Next, the dipeptidase ataJ removes the Glu residues (PubMed:23586797).  The following step is performed by the carbon sulfur lyase domain ataI of ataIMG which may convert the bis-cysteinyl adduct to yield an epidithiol intermediate (PubMed:23586797).  The ataT domain from ataTC then catalyzes the oxidation of the free dithiols, followed by a cyclization step catalyzed by the cytochrome P450 ataF (PubMed:23586797).  AtaF probably acts as an epoxidase to promote a dual epoxidation formation at C8 and C9 along with C8' and C9', followed by the spontaneous nucleophilic attack of the amide nitrogens N10 and N10' to yield an intermediate with the pyrrolidine partial structure (PubMed:23586797).  The final steps of acetylaranotin biosynthesis involve the acetylation and ring rearrangement of an epitetrathiodiketopiperazine intermediate to produce acetylaranotin (PubMed:23586797).  AtaH probably catalyzes the acetylation of epitetrathiodiketopiperazine to produce a diacetate and ataY is responsible for the formation of the dihydrooxepin moiety that converts the diacetate intermediate to acetylaranotin via acetylapoaranotin (PubMed:23586797).  Both enzymes could function independently in the absence of the other (PubMed:23586797).  The acetylaranotin bis-thiomethyltransferase ataS located outside of acetylaranotin gene cluster is the main thiomethyltransferase responsible for converting acetylaranotin and its related intermediates to their methylated forms (PubMed:30096370).
What are the official names of this protein?
Cytochrome P450 monooxygenase ataY, Acetylaranotin biosynthesis cluster protein Y.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: RS4_HELPJ
Sequence: MARYRGAVERLERRFGVSLALKGERRLSGKSALDKRAYGPGQHGQRRTKTSDYGLQLKEKQKAKMMYGISEKQFRSIFVEANRLDGNTGENLIRLIERRLDNVVYRMGFATTRSSARQLVTHGHVLVDGKRLDIPSYFVRSGQKIEIKEKTKSNPQVVRAMELTAQTGIVPWIDVEKDKKYGIFTRYPEREEVVVPIEERLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: NUSB_CLOB8
Sequence: MNRKLSREKAMELLFGMTLSKDTMEDAVEAFVENYEGDIKEIDLTYVKQVLIGVNNNKEAIDKVIQENLHNWKIERISKVNLSILRIATYELLYDKEVPRGVAINEALEITRRYSDEKSVSFINGVLDKIKQD
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: AAEA_ECOL5
Sequence: MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQPRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRDDKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG
What is the function of this protein?
Forms an efflux pump with AaeB.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeA, pHBA efflux pump protein A.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: AROA_SALTY
Sequence: MESLTLQPIARVDGAINLPGSKSVSNRALLLAALACGKTALTNLLDSDDVRHMLNALSALGINYTLSADRTRCDITGNGGALRAPGALELFLGNAGTAMRPLAAALCLGQNEIVLTGEPRMKERPIGHLVDSLRQGGANIDYLEQENYPPLRLRGGFTGGDIEVDGSVSSQFLTALLMTAPLAPKDTIIRVKGELVSKPYIDITLNLMKTFGVEIANHHYQQFVVKGGQQYHSPGRYLVEGDASSASYFLAAGAIKGGTVKVTGIGRKSMQGDIRFADVLEKMGATITWGDDFIACTRGELHAIDMDMNHIPDAAMTIATTALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPAKLQHADIGTYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARMSTPA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXG_BLUGR
Sequence: MLYPRALLPAAVALASLVLAVPLEERQLAFDFNNQKVRGVNLGGWFVLEPWITPSIFQQWANGGDVIDEYSYTAALGKDEAFTRLNNHWATWITEEDFAEIASMGLNHVRIPIGYWALVAIPNDPYVQGQLSYVDRAIDWARKNGLKVMLDLHGAPGSQNGFDNSGRTGTIAWQSGDNVPNTLRAIQALAERYAPQTDVVTAIELLNEPANWGNDLSQIKKFYYDGWGNVRTQGQTAVTIHDAFLDPRSWNGFMNSEAGVNNVILDTHIYQVFSQNEVAMKPCAHVQTACSSIDKIKPTDKWTIVGEWTGAQTDCAKWLNGLGKGARYDGTLPGHSEGYYGSCDKKYEGTVDSMLPVDKTNLQYFVEAQLDAYESHTGWFFWTWKTESAPEWHFQNLTRAGLIPQPLDSRKVPSQCGTSQCLVPGN
What is the function of this protein?
Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall.  It could also function biosynthetically as a transglycosylase (By similarity).
What are the official names of this protein?
Glucan 1,3-beta-glucosidase, Exo-1,3-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.