PharMolix/UniProtQA huggingface dataset:
Protein: CWC22_XENLA
Sequence: MKSSVAQVRGSNYDKVDTRSSSERSSSPEDSNEERSPSPRDRGYSNRSRDYSDRDRYEDRSRSGRYDRSDESRRRERERSTSPRDRGYTDRRRGYSDRDGYGNDRSRNGRYDRSEDNREREKRQNYQDRDYEKRSPPARRRSPPARRSEEQTEEQNQTEPPVKKKKEELDPILTRTGGAYIPPARLRMMQEQITDKSSMAYQRMSWEALKKSINGLVNKVNVSNIGNIIQELLQENIVRGRGLLARSVLQAQSASPIFTHVYAALVSIINSKFPHIGELILKRLILNFRKGYRRNDKQLCLTSSKFVAHLINQNVAHEVLALEMLTLLLERPNDDSVEVAIGFLKESGLKLTQVTPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPVIPEGLDLVEEEDQFTHMLPLEDDYNQEDVLNVFKMDPDFLENEEKYKAIKKEILDEGDSDSEGDANEGSEDESEEEEEDGQEAGTEGEKMTIHDKTEVNLVAFRRTIYLAIQSSLDFEECAHKLIKMDFPESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCLLKKEYLEAFENIFKEQFETIHRLETNKLRNVAKMFAHLLYTDSLPWSVLECMNLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDVTLQPFFQGLLPMDNPKNTRFAINFFTSIGLGGLTDELREHLKNAPKMIMTQKQNVESSDSSSDSSSGSESSSDSDSSSSSSSESSSSSSDSDSSRRKKHSQKKKKSREAHKAASKKQAPDDRRKEAPKHKHQKEKYDDKQSRKSKRDSKN
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome.  Promotes exon-junction complex (EJC) assembly.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC22 homolog, Nucampholin homolog.
What is the protein family that this protein belongs to?
Belongs to the CWC22 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins.
Protein: EFTU_MYCPA
Sequence: MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKYPDLNESRAFDQIDNAPEERQRGITINISHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADMVDDEELLELVEMEVRELLAAQEFDEDAPVVRVSALKALEGDAKWVESVEQLMEAVDESIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVINVNEEVEIVGIRPSSTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGIKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTNISVKLIQPVAMDEGLRFAIREGGRTVGAGRVVKIIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCL9_HUMLU
Sequence: MANNITLTGLLKKAAAEFSDRRAILVSGEFHLTHARLQEIVDHAASLLLASGVGHGDVVALTFPNTIEYIVMFLAVIRCRAVAAPLNSAYTAEEFEFYLSDSESKLLITPPKGIEAARAAASKLNITHVTATLPGGDGLIALSPSPNNESSLDAVAELTNDPSDVSLFLHTSGTTSRPKGVPLTQLNLASSVQNIKSVYKLSESDSTVVVLPLFHVHGMIAGLLSSLIAGSAVTLPAAGRFSASTFWSDMIACNATWYTAVPTIHQIILDRHLNKPEPTYPKLRFIRSCSASLAPTIMGRLEESFGAPVLEAYAMTEAAHLMASNPLPEDGGHKPGSVGKPVGQEMAILDLNGSAQLPGFSGEVCIRGPNVTKGYKNNPEANKAAFQFGWFHTGDVGYFDEDGYLHLVGRIKELINRGGEKISPIEVDAVLLSHPDLAQAVAFGVPDDKYGEEINCAVIPREGSEVDEDGVLRFCKKNLAAFKVPKKVFITDSLPKTATGKIQRRIVAEHFLAQISTAKVPKFGA
What are the official names of this protein?
Probable CoA ligase CCL9, HlCCL9.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ANGP1_HUMAN
Sequence: MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTDQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRATTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF
What is the function of this protein?
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation.  Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence.  Required for normal angiogenesis and heart development during embryogenesis.  After birth, activates or inhibits angiogenesis, depending on the context.  Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts.  In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades.  In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis.  Mediates blood vessel maturation/stability.  Implicated in endothelial developmental processes later and distinct from that of VEGF.  Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
What are the official names of this protein?
Angiopoietin-1, ANG-1.
What are the subcellular locations of this protein?
Secreted.
Protein: CP1A1_SHEEP
Sequence: MWIMFSVFGLPIPISATELLLASAVFCLVFWVVRTWRPRVPQGLKSPPEPWGWPCLGHVLTLGKNPHVVLSQLSQRYGDVLQIRIGCTPVLVLSGLDTIRQALVRQGDDFKGRPDLYSFTLVSDGQSMTFNPDSGPVWAARRRLAQNALKSFSTASDPASLSSCYLEEHVSKEAEYLLGKFQELMSGPGRFDPYRYVVVSVANVICAICFGRRYDHDDQEFLSLINLSNEFGEITASGNPADFIPVLRYLPNTALDLFKDLNRRFYVFVQKIVKEHYKTFEKGHIRDITDSLIEHCQDKRLDENANIQLSDEKIINVVMDLFGAGFDTVTTAISWSLLYLVTSPRVQKKIQEELDTVIGRARWPQLSDRPQLPYLEAFILETFRHSSFVPFTIPHSTTRDTNLNGFYIPKGXCVFVNQWQINHDQKLWEDPSEFRPERFLTTDGTVNKVLSEKVIIFGLGKRQCIGEIIARLEVFLFLAILLHQVEFHVTPGVKVDMTPLYGLTMKHARCEHFQVRIRS
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions.  Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation.  Catalyzes the epoxidation of double bonds of certain PUFA.  Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system.  Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer.  May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues.  Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid.  May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).
What are the official names of this protein?
Cytochrome P450 1A1, CYPIA1, Cytochrome P450 form 6, Cytochrome P450-C, Cytochrome P450-P1, Cytochrome P4501A1, Hydroperoxy icosatetraenoate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Cytoplasm.
Protein: RF3_SALRD
Sequence: MDPVLKDEIEKRRTFAIISHPDAGKTTLTEKLLLKGGAIHEAGEIKARKADRFAMSDWMTMEKERGISVTSSVMKFPYRGYELNLLDTPGHRDFSEDTYRVLTAADSVIMVLDNASGVEQQTEKLMEVCRMQDTPIITFVNKMDRHGLPPLDILEDIEDTLDLDTVPLSWPIGMGNRFRGTYNLYRDELHLFSHADMDGEHERLPIDDLDDPQLDEVLGDQADDLRFDVELVREAGDELDLQAYLGGKQTPVFFGSALSNFGVGDMFDTFVEIAPPPQPRPTVTRDVSPYEDDFTGVAFKIQANMDPKHHDRMAFVRVCSGKFEKGMEVIHHRTGQTMRLNNATTFMAQDREGVDTAYPGDIIGIMSHGRVKIGDSFSTAEPLHFTGVPSFAPEHFRKVRLDDPFRSKHLSKGLQQLSEEGTIQAFRPLRGNDYILGAVGELQFDVTLDRLEDEYNVDAHLTGVRYACCRWIDGPAEDLEDFEAENMDSLFRDAGGDLAYLALSDFRLERTMENWPRISFNSTKQHTAEEERS
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_NEIMB
Sequence: MKKVFIRTFGCQMNEYDSDKMLAVLAEEHGGIEQVTQADEADIILFNTCSVREKAQEKVFSDLGRVRPLKEKNPGLIIGVAGCVASQEGENIIKRAPYVDVVFGPQTLHRLPKMIVDKETSGLSQVDISFPEIEKFDHLPPARVEGGAAFVSIMEGCSKYCSFCVVPYTRGEEFSRPLNDVLTEIANLAQQGVKEINLLGQNVNAYRGEMDDGEICDFATLLRIVHEIPGIERMRFTTSHPREFTDSIIECYRDLPKLVSHLHLPIQSGSDRVLSAMKRGYTALEYKSIIRKLRAIRPDLCLSSDFIVGFPGETEREFEQTLKLVKDIAFDLSFVFIYSPRPGTPAANLPDDTPHEEKVRRLEALNEVIEAETARINQTMVGTVQRCLVEGISKKDPDQLQARTANNRVVNFTGTPDMINQMIDLEITEAYTFSLRGKVVEA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED27_DICDI
Sequence: MQVQQPQQIQQQHLQQQQAQQHQQQQVQQHQQQQQQQQQQQQIYQQIVNQPVNNVHQLPSLQQQQLLEQYDELLKQVSLIRSNVSDFFNSFIEDAKQQQTIVNKEEMKQKLKKSMDLVLGSISSIDKVSKRISSYSFQIASSNFSTQEASWAYSTGIYDNRNIKVQLEIRNENYWRSQTSYKSSLASSNLENKLKDLFPIIFQEDEESSSLSKKRKQISSLTSNSLSTTTITTTTTPSPLFKLPSTPPTLLLSGTISPFYDYFAQIERVIHSIRQESALEIFEIQKQSSGAPKGLFVECPDVFKCLICFGIPNDRKDCFTIDRISFFGVKENFDSLWASSKYNIFKKISENSFEAISYYSANPNGGSILKCILSWIWSFRGLFLEECKGCQDILHLDSPQYMYLPPSFRTFDNYTPYHPSCYQNHLLSCNSFSSSTSSSIQQSPFSPLNK
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Putative mediator of RNA polymerase II transcription subunit 27, Putative mediator complex subunit 27, Putative mediator complex subunit 3, Putative mediator of RNA polymerase II transcription subunit 3.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 27 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SERC_BUCAT
Sequence: MNLIYNFSAGPAMIPRDVLNQAKKELHNWKNLGSSIMEISHRSEEFIQMALEAEKDLRDLLKIPDSFKVLFCQGGARGQFSAIPMNLLNNLQTADYINSGYWSNSAFMEAKKYCTPRSIFIRETNGVKESLLPMHKWNINENSAYIHYCPNETIDGLSIYEEPVFENKIIVGDFSSFILSRSINIKNYDLIYAGAQKNIGPAGITIIIIRKNIIGSSSKMTPSILDYKKISDHHSMFNTPPTFAWYLSGLVFKWLKKQGGLKAIEKLNKKKSDLLYKKIDNSDFYINKINSKHRSQMNVVFHLVNPKLNYIFLKEASKTGLNYLRGHSIVGGMRASLYNAMPLEGVESLVKFMSYFEKRYG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GALM_ECOLI
Sequence: MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRIANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRKVKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHPEWPQPDCFLRPGEEYSSLTEYQFIAE
What is the function of this protein?
Mutarotase converts alpha-aldose to the beta-anomer.  It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.
What are the official names of this protein?
Aldose 1-epimerase, Galactose mutarotase, Type-1 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the aldose epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_SYNAS
Sequence: MAYERRSRPSGPRKKFFHRRKYCKFCSDSTIKIDYKRPDILHDYITERGKIMPRRITGSCSKHQRELTQAIKRARSIALLPFVVTEGR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: USPE_ECOLI
Sequence: MAMYQNMLVVIDPNQDDQPALRRAVYLHQRIGGKIKAFLPIYDFSYEMTTLLSPDERTAMRQGVISQRTAWIHEQAKYYLNAGVPIEIKVVWHNRPFEAIIQEVISGGHDLVLKMAHQHDRLEAVIFTPTDWHLLRKCPSPVWMVKDQPWPEGGKALVAVNLASEEPYHNALNEKLVKETIELAEQVNHTEVHLVGAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGINENMTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGISAAFLGNTAEQVIDHLRCDLLVIKPDQYQTPVELDDEEDD
What is the function of this protein?
Required for resistance to DNA-damaging agents.
What are the official names of this protein?
Universal stress protein E.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIS_PYRAE
Sequence: MIVEVFFRNFYRNFAKFEIDAVDKREFAFQPFSGGMVRHKSFKSLEDLRKFVVEKTPRHIYHSAAYYERPGEEDMERKGWIGADLIFDIDGDHLDTEACRESKIVSLRCLEDAREEANKLIDVLIQELDLKPTRIVFSGNRGFHIHVSSEEVMKLGSRERRELVNYLKAVGFDPSRFIAKLGRRKVVLYEEEAVGNLLRIKQGVEDARAMKVEIDEVVTQDIHRLIRAPGSLNGKTGLVALPISLKELDKGVEYIVDKAIAFRKGHLKFKFEKPVEGPVLFEKVGGREGDVKVLPAYVAIYLELQEFGKIYD
What is the function of this protein?
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  The small subunit contains the primase catalytic core and has DNA synthesis activity on its own.  Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase small subunit PriS.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: RL19_CHLCV
Sequence: MGNLIKELQDEQLRKEALTDFRVGDTIRVATKIVDGGKERTQVFQGTVMARRGGGAGETVALHRVAYGEGMEKSFLLHSPKIVGIEVVKRGKVSRARLYYLKGKTGKAAKVKEYIGPRAPK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SHUT_ADE02
Sequence: MESVEKEDSLTAPFEFATTASTDAANAPTTFPVEAPPLEEEEVIIEQDPGFVSEDDEDRSVPTEDKKQDQDDAEANEEQVGRGDQRHGDYLDVGDDVLLKHLQRQCAIICDALQERSDVPLAIADVSLAYERHLFSPRVPPKRQENGTCEPNPRLNFYPVFAVPEVLATYHIFFQNCKIPLSCRANRSRADKQLALRQGAVIPDIASLDEVPKIFEGLGRDEKRAANALQQENSENESHCGVLVELEGDNARLAVLKRSIEVTHFAYPALNLPPKVMSTVMSELIVRRARPLERDANLQEQTEEGLPAVGDEQLARWLETREPADLEERRKLMMAAVLVTVELECMQRFFADPEMQRKLEETLHYTFRQGYVRQACKISNVELCNLVSYLGILHENRLGQNVLHSTLKGEARRDYVRDCVYLFLCYTWQTAMGVWQQCLEERNLKELQKLLKQNLKDLWTAFNERSVAAHLADIIFPERLLKTLQQGLPDFTSQSMLQNFRNFILERSGILPATCCALPSDFVPIKYRECPPPLWGHCYLLQLANYLAYHSDIMEDVSGDGLLECHCRCNLCTPHRSLVCNSQLLSESQIIGTFELQGPSPDEKSAAPGLKLTPGLWTSAYLRKFVPEDYHAHEIRFYEDQSRPPNAELTACVITQGHILGQLQAINKARQEFLLRKGRGVYLDPQSGEELNPIPPPPQPYQQPRALASQDGTQKEAAAAAAATHGRGGILGQSGRGGFGRGGGDDGRLGQPRRSFRGRRGVRRNTVTLGRIPLAGAPEIGNRSQHRYNLRSSGAAGTACSPTQP
What is the function of this protein?
Protein that inhibits host translation while promoting late viral translation by ribosome shunting.  Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation.  Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell.  During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers (Probable).
What are the official names of this protein?
Shutoff protein, 100 kDa protein, p100K, 100K-chaperone protein, L4-100K, Shutoff protein 100K.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae shutoff protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: HOG1_ALTBR
Sequence: MAEFVRAQIFGTTFEITSRYTDLQPVGMGAFGLVCSAKDQLTSQAVAIKKIMKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTICSENTLRFVQSLPKRERQPLSNKFKNAEPQAVDLLENMLVFDPKKRVRAEQALAHPYLAPYHDPTDEPIAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVDAAAQEQENNGS
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase HOG1, MAP kinase HOG1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL362_SALPA
Sequence: MQVLNSLRNAKQRHPDCQIVKRKGRLYVICKTNPRFKAVQGRKKRR
What are the official names of this protein?
50S ribosomal protein L36 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: UVRC_METTH
Sequence: MTRVKDPEKLPDATGVYIFRDRDDRVLYVGKSISIRKRVSSYFREQENPRLRIMMRHLESIEYILTQNEKEALILESNLIKRYRPPYNVRLKDDKRYPFIKITDEEYPRVLIVRTIGRDSARYYGPFTDTGAVRRTLKLIKSLFRIRSCRRMDGPCLNSQIDLCYAPCDGRISREDYREIIEKVDLFFQGRYQEVIEVLEEEMKEASERLEFERAARIRDQIESIREVMERQHASFTDSIDQDIVALERGGDTSAVVVLQIRDGKITGKDDFILRGSAPRTEILEAFLKQYYAIPRRVPSEILTQYPVEDGVIAEWLSELRGEEVKIHSPEGGAGRRLLNIAWKNASVILKQKGRVRDALLQLKDDLKLPEIPRRMEGLDISNIAGESATGSVAVFIDGKPSSGSYRRYRISAQGPDDYAMMRELVERRYSSPELRKPDLVLIDGGKGQLGVALEALKNCGVHVPVVGIAKKREEVYLPGLSEPVDVDDGALQILRHLRDEAHRFAVKYHRTIRDRDSLESELDGIRGVGPVRKRALLEHFGSLDGVRDASVEELASIPGMTREVAERIHRHFSGDLAG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_STRR6
Sequence: MSQSYINVIGAGLAGSEAAYQIAERGIPVKLYEMRGVKSTPQHKTDNFAELVCSNSLRGDALTNAVGLLKEEMRRLGSVILESAEATRVPAGGALAVDRDGFSQMVTEKVANHPLIEVVRDEITELPTDVITVIATGPLTSDALAEKIHALNDGDGFYFYDAAAPIIDVNTIDMSKVYLKSRYDKGEAAYLNAPMTKQEFMDFHEALVNAEEAPLNSFEKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQLRQDNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLEQTYRSKKQPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKEESEVIFPETTAIGSLAHYITHADSKHFQPMNVNFGIIKELEGERIRDKKARYEKIAERALADLEEFLTV
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_SOLUE
Sequence: MFKGFQKPKRLVANTETLTERYGMFTAQPFQRGFGTTIGNSLRRVLLSSIEGAAITAVRIEGVEHEFSPIPGVVEDATDIILNLKQIPFKISSDGIKTVRLSVDSHGDVRSGQIETDADVEVLDRDVHVATVSEGGKLNIEMRLKSGRGYVSADKNFDEDLALGYIPIDSVHSPVRKVNFAVEAARLGQMTDYDKLTLEVWTNGAVSPQDSIGYAAKLLKDHMTIFINFEEVPEQTEEISERGMDKMNEVLNRSVEELELSVRSYNCLKNANIQSIGELVQKTEAEMLRTKNFGRKSLNEIKEILANMGLSLGMRIDQHGRLVAPPPSAGGGPDFGPEDDGQDQIGE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: LOLA_CUPMC
Sequence: MRYRILAPLVSLGAALALLAAAPVAQAAATDQLQSFVTSVKTARGEFTQQQMKGKGADLKVASTSSGTFVFSRPGKFAWRYTKPYEQLLQADGQVLYIYDKDLNQVTERKLDGALGSSPAAILFGSNDLSKNFDVKNGATRDGVEWLELTPKEKDTQFERIGIGFKGGNLEAMELRDAFGNTTILTFSAIQKNPSLPADAFRFTVPKGADVMKQ
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TBG_EUPAE
Sequence: MPREIITCQVGQCGNQIGMEFWKQLCMEHGINPEGILEDFAVNGEDRKDVFFYQADDEHYVPRAVLIDLEPRVINCIQKSTYSSLYNPENIYIAKHGGGAGNNWGRGYTDAEKVQDEILEMIDREADGSDSLEGFVLTHSIAGGTGSGFGSYLLERINDHYPKKLIQTYSVFPIENDVVVQPYNCLLSIKRLTLNADCVVVLDNNALTSIAVDRLKILQPTFSQINSIVSTVMAASTTTLRYPGYMNNDMVGLIASLVPTPRCHFLMTGYTPLSLDQKYTSVRKTTFLDVMRRLLQTKNIMVTGAVKKGAYMSILNVIQGDVDPTQVHKSLQRIKERKLANFIPWGPASIQVALAKKSPYIDSGHKVSGLMLANHTGIRSIFKVLYDQYRTFRKRDAYMNIFKQTKIFEDNLDEFDSSDEVVKNLIDEYAAAEKMDYINWGNDDDDMQFDPREPPKFSNIQ
What is the function of this protein?
Tubulin is the major constituent of microtubules.  The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
What are the official names of this protein?
Tubulin gamma chain, Gamma-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.