PharMolix/UniProtQA huggingface dataset:
Protein: DNAA_PELPD
Sequence: MHDVWRQATENLEKVMSESDFTTWIQPISYSHADDTTVFLTVPTLFFKEWIDEHYRQVLVGALSVTAGKKYFIELVVQEEDQNAEVPQAEDLIIKGHQEIEQPVTSQPETSSSSLNPKYTFELFVSGTGNQFAHAAAMAVANNPADTYNPLFIYGGVGLGKSHLLNAIGHTIRSSSPNLSVCYCSAEKFMYEMVNALRQKRMDQFRSRFRNLDVLLVDDIQFISGKVGTQEEFFHTFNALYDMQKQIVITSDKFPREISDLEERLRSRFEWGLIADIQPPDLETKIAILKKKSEITRIQLPEDVIYFLASSDTRNIRELEGMLIRLGAYSSLQGIPITLDMARENLKEIIGDRRKDITVELIQKVVAEQFGLKMADLKSSKRLKNFVQARQIAIWLCRDMTSFSYPDIGAKFGGKDHSTVIYAAKKIDLALKDDPKLSRIIEDIKLILLK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_RHOP2
Sequence: MIRAFDAFSLPLLRLLDAEDAHRLAIQGLRLLPQVKPRPDDSKLAVRAFGLNFPNPVGIAAGFDKNAEAPDALLRLGFGFVEIGTVTPKPQAGNPRPRLFRLERDEAIINRMGFNNDGAEAVLRRLAARAQQGGIVGVNVGANKDSTDRVADYVSLIETFAPVASYFTVNVSSPNTPGLRNLQQAAALDDLLARVIEARERVRASAGDTPVLLKIAPDLTLSELDDVVHIARSRRVDGMIVANTTLSRSPMLRERTRLNEQGGLSGRPLFRLSTRMVAETYVRAEGAFPLIGVGGIDSGGAALTKIRAGASLVQLYSALIYKGLGLVDSIKADLASTLLRTGRDSLSEIVGADAPTITAEEWPV
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DYR_NEIMA
Sequence: MLKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRRNIVISRQADYCAAGAETAASLEAALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSVEGDAFFPAIDRTHWKEAERTERRVSSKGTSYAFVHYLRY
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: RS8_BURP0
Sequence: MSMSDPIADMLTRIRNAQMVEKVSVSMPSSKVKVAIAQVLKDEGYIDDFAVKADGAKAELNIALKYYAGRPVIERLERVSKPGLRVYRGRNEIPQVMNGLGVAIVSTPKGVMTDRKARATGVGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ISPG_NITEU
Sequence: MSSNNVPASRRKCVGVKVGSVMIGGGAPIVVQSMTNTDTADEVSTTQQVAQLALAGSELVRITVNSMEAARAVAGIRARLDDMGCHVPLVGDFHFNGHKLLTAYPECARALAKYRINPGNVGHGRKRDEQFSLLIETACKYDKPVRIGVNWGSLDPEMLARIMDENARSPDPLGASQVMHKALITSALESAARAEELGLARDHIVLSCKVSGVARQQDMIAVYGALAEQCDYALHLGLTEAGMGSKGIVASTAALAVLLFKGIGDTIRVSLTPEPGGDRAREVIVAQEILQTMGLRAFVPLVAACPGCGRTTSTYFQELAESIQIYVREQMVIWREQYEGVENMSLAVMGCVVNGPGESKHADIGISLPGSGETPVAPVFVDGQKTVTLKGDNIAGEFRMIVDEYVRTKYRKKAANA
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: ACPS_STRPN
Sequence: MIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLKGRRQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLSISHTDQFVTASVILEENHES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_TREDE
Sequence: MRTGLGYDLHRLVRGKKLMMGGVHIPFKKGEKAHSDGDVLLHAITDALLGACGMGDIGEFFPPSDKKWKDANSSELLSTVWERISEAGWKIQNIDCVIIIEEPKILPFREEIRKSIAGILKIEKEQIFIKAKTGEGIGIIGRGKAVAALASCLIFCRHTQE
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: PLSX_GEOSW
Sequence: MKIAIDAMGGDHAPKEIVLGAMKAVQHFSDVHITLFGDEGKIRPYLTSDERITVIHTNEVIEATDEPVRAVRRKKQSSMVLMAEEVKEGRADACISAGNTGALMAAGLFVVGRIAGIDRPALAPTLPTIGGEGFLFLDVGANVDARPEHLLQYALMGAVYAEKVRGIPRPRIGLLNVGTEDQKGNDVAKKAFQLLRETDLNFIGNVEARDLLHGVADVVVTDGFTGNVALKTIEGTAISVFSMLKEALTSSFLSKLAAAILKPKLIDLKKTMDYSEYGGAALFGLNAPVVKAHGSSDANAIFHAVRQAREMVANDIITTIKEAIEQNHS
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: HMGCL_HUMAN
Sequence: MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
What is the function of this protein?
Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis.  Terminal step in leucine catabolism.  Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
What are the official names of this protein?
Hydroxymethylglutaryl-CoA lyase, mitochondrial, HL, HMG-CoA lyase, 3-hydroxy-3-methylglutarate-CoA lyase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA lyase family.
Protein: PROF8_MAIZE
Sequence: MSWQAYVDEHLMCEIEGHHLTSAAIVGHDGAAWAQSTAFPEFKTEDMANIMKDFDEPGHLAPTGLFLGPTKYMVIQGEPGAVIRGKKGSGGITVKKTGQALVVGIYDEPMTPGQCNMVVERLGDYLLKQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-8, Pollen allergen Zea m 12, Pollen profilin variant 3.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MAOM_HUMAN
Sequence: MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE
What is the function of this protein?
NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.
What are the official names of this protein?
NAD-dependent malic enzyme, mitochondrial, NAD-ME, Malic enzyme 2.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: Y1115_HALSA
Sequence: MYATPIGYADTRFETAADAPRQGVETPYAANVQVYESFRGGLVGLEPDDRVVVVWWADDADRDVLAVRDGDRGVFTTRSPARPNPVCITPCELLAVDAADGTLAIRGVDMAHGSPVLDLKPALD
What are the official names of this protein?
Probable S-adenosyl-L-methionine-binding protein VNG_1115H.
What is the protein family that this protein belongs to?
Belongs to the tRNA methyltransferase O family.
Protein: NORB_STAA3
Sequence: MEKPSREAFEGNNKLLIGIVLSVITFWLFAQSLVNVVPILEDSFNTDIGTVNIAVSITALFSGMFVVGAGGLADKYGRIKLTNIGIILNILGSLLIIISNIPLLLIIGRLIQGLSAACIMPATLSIIKSYYIGKDRQRALSYWSIGSWGGSGVCSFFGGAVATLLGWRWIFILSIIISLIALFLIKGTPETKSKSISLNKFDIKGLVLLVIMLLSLNILITKGSELGVTSLLFITLLAIAIGSFSLFIVLEKRATNPLIDFKLFKNKAYTGATASNFLLNGVAGTLIVANTFVQRGLGYSSLQAGSLSITYLVMVLIMIRVGEKLLQTLGCKKPMLIGTGVLIVGECLISLTFLPEIFYVICCIIGYLFFGLGLGIYATPSTDTAIANAPLEKVGVAAGIYKMASALGGAFGVALSGAVYAIVSNMTNIYTGAMIALWLNAGMGILSFVIILLLVPKQNDTQL
What is the function of this protein?
Multidrug efflux pump that acts independently of NorA and is one of the factors that confers resistance against diverse quinolones and chemical compounds.
What are the official names of this protein?
Quinolone resistance protein NorB.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CML27_ARATH
Sequence: MASANPETAKPTPATVDMANPEELKKVFDQFDSNGDGKISVLELGGVFKAMGTSYTETELNRVLEEVDTDRDGYINLDEFSTLCRSSSSAAEIRDAFDLYDQDKNGLISASELHQVLNRLGMSCSVEDCTRMIGPVDADGDGNVNFEEFQKMMTSSSLLNSNGSAAPPST
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML27, Calmodulin-like protein 27.
Protein: Y528_ACIET
Sequence: MLISIDQVLSKTEVRDLRAQLDAAAWEDGAATAGTLAKSVKRNQQINDGSELCQRLGQHILRRLSSTPLFISAALPRTIYPPKFNRYADGGTYGAHVDSALMFLPGSHQQMRTDLSATLFLAEPEEYDGGELEVEGPFGVQAVKLAAGDMVLYPSSSLHRVTPVTRGARVASFFWIESLVQDEGERTLLFDLDQSIQQLTPLVAPDDPRLVQLTGVYHNLLRRWARP
What are the official names of this protein?
PKHD-type hydroxylase Dtpsy_0528.
Protein: DAPB_ALIF1
Sequence: MVRVAIAGAAGRMGRNLIKAVNGSQFAVLAAASERPESSLIGVDVGEMAGLGKSGILIVDDLAKVTDDFDVIIDFTLPISTLKNIELCQEHNKAIVIGTTGFSEPGKEIIDQASKEIPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRYKVDAPSGTAIGMGEAIAGAMGNKLEDVAVYAREGITGERSKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVRASHWLHKKEPGFYTMHDVLNLDQI
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_LEGPH
Sequence: MVVAPYLAVAIGGSLGAMSRYLVTIMAQNAWGIKFPYGTLLVNTLGSFLAGFFLIVLVGRFSAEESFRLFLFTGFLGAFTTFSSFAAESLFMFEQGYWFKLMTNILVNNVGSLSMVFIGTLVAKYVLLGHQGSN
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1937_STRP7
Sequence: MDLLLAIVLIVLAFLGGALGGMYLVRKQIEKEFADNPRLNAEAVRTLLSANGQKPSEAKVQQVYHQIIRQQKAALANNKKKK
What are the official names of this protein?
UPF0154 protein SP70585_1937.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL29_SALPB
Sequence: MKAKELREKSVEELNTELLNLLREQFNLRMQAASGQLQQSHLLKQVRRDVARVKTLLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: UGPE_YERPA
Sequence: MIENRRGLDIFCHIMLIIGVLLILFPLYVAFVAASLDDSQVFQAPMTLIPGPHLWQNISHIWHAGVGNNSTPFGLMLLNSFVMAFAITVGKITVSILSAYAIVYFRFPLRNLFFWLIFLTLMLPVEVRIFPTIEVIANLNLLDSYTGLTLPLMASATATFLFRQFFMTLPDELLEAARIDGAGAMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPILITSDASMGTAVAGIRSMISTSGAPTQWNQVMAAMILTLIPPVVVVLLMQRWFVRGLVDSEK
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpE.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPE_BARHE
Sequence: MENNRVNHFLFELVSPEKPVFSEQVVSVVLPSASGALTVMANHAPLVASIVLGSMYVLTSSGEKLFAVCGGVANITSSGCSVLVERVVVVQHLSFHDLEQRILRVRATLEGDSNDGISHKIEDFFHQLKVGDAGLTEA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YBEY_CORA7
Sequence: MSIEFINESGYDGVNEEMLIDVCSYALGCLDVNPDAECTITAVDLDTIADLHVRWMDLEGPTDVMSFPMDELTPGASAGRPDAVEAGPAMLGDIVLCPEFAQRQATAAGHSLGHELALLTVHGCLHLLGYDHTTAAEEKEMFGLQNELLADWYEDLAARGVSYQPKPSGPKAFPDAAERAELDKEVPGGGI
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_MAGSA
Sequence: MADLAKLVDDLSALTVLEAAELSKLLEEKWGVSAAAPVAVAAVAAGAAAPAAEEQTEFDVILTDAGEKKINVIKEVRAITGLGLKEAKDLVEAAPKSVKDGVSKDEAEKIKKVLEEAGAKVQVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: METE_BACHK
Sequence: MAIQTSNLGYPRIGLQREWKKTLEAFWSNKINEEQFLTTMKEIRLQHVKVQQEKGIELIPIGDFTYYDHVLDTAYMLGFIPSRFSEFTSYLDVYFAMARGSKDHVASEMTKWFNTNYHYIVPEYEEGLQISLKDNRPLRLYEEAKQELGVDGKPVILGPYTFLKLAKGYTQEQFATILKQLVAPYVQLLSELHAAGAQIIQVDEPIFASLTKEEVQQAKEIYEAIRKEVPNATLLLQTYFDSVEENYEEFITFPVSSIGLDFVHGKEGNLNAISKYGFPADKTLAVGCIDGRNIWRADLDEVLTLFTTLQKQVQTKDLIVQPSCSLLHTPIDKTEETHLSTELFDALAFANQKLEELVLIHSALTQGTESISNELETYRNVHHTIRSSAARNREDVKAARTALKEEDFSRPLPFEKRYELQQVALKLPLLPTTTIGSFPQTTEVRQTRKEWRNGIISNEQYEQFIEKETEKWIRYQEEIGLDVLVHGEFERTDMVEYFSERLAGFSFTKNGWVQSYGSRCVKPPVIYGDVAFINGMTIKETVYAQSLTEKVVKGMLTGPVTILNWSFVRNDIPRKEVSYQIALALRHEIELLESSGIRVIQVDEPALREGMPLKEKDWDAYITWAVQSFLLATSSVANETQIHTHMCYSNFEDIVDAIRALDADVISIETSRSHGEFIDTLKHTTYEKGIGLGVYDIHSPRVPSKDEMYKIVEQSLQVCDPKYFWINPDCGLKTRRTEEVIPALEHMVQAAKDARSLLKTNA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: FLOA_LISMO
Sequence: MTMIGPIIIAVLIIIFLIVFFTLVPVGLWISALSARVPVGLGTLIGMRLRRVVPSRVVKPLIKAVKAGLDLEVNQLESHYLAGGDVDNTVDALIAAHRANIELDFSRAAAIDLAGRDVLEAVQTSVTPKVIRTPEFTGVAQNGVEVKVITQITVQSNIERIVGGAGEDTVIARVGEAVVSTVGETREHTDVLENPNSISKKVQEQGLGDGTAYTILSIDIAEMRIGDNIKAKLDIEKANADMEVAQAAASKRKAEAIALEQENRAAVVAAEAEVPRALSRALEEGNLGVMDYYKMENVQSDTAMRESIAHEDEK
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Membrane raft; Single-pass membrane protein.
Protein: AZOR_BACP2
Sequence: MAKVLYITAHPHDETVSYSMATAKAFIESYKEANPSDEVVHIDLYKENIPHIDADVFAGWGKLQSGAGFDTLSAEEQAKVARLNELSDQFVSADKYVFVSPLWNFSFPPVLKAYIDSVAVAGKTFKYTEQGPVGLLTDKKALHIQARGGYYTEGPAAELEAGHRYLGTIASFFGIPSFEGLIVEGHNAEPAKAEQIKADAIERAKALGKTF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: MNMG_XANCB
Sequence: MSDSFYRYDVIVIGGGHAGTEAALAAARAGARTLLLTHNIETVGAMSCNPAIGGIGKGHLVKEIDALGGAMAKAADLAGIQWRTLNASKGPAVRATRCQADRNLYRSAIRRIVEAQPNLTVFQAAVDDLIIHNGAAEGDSVRGVITQTGLRFEATAVVLTAGTFLAGKIHVGETQYAAGRMGDPPATTLAARLRERPFAIDRLKTGTPPRIDGRTLDYTMMDEQPGDDPLPVMSFMGQVSDHPTQVSCWITHTTEQTHDIIRGALHRSPLYSGQIEGIGPRYCPSIEDKVVRFADKTSHQIFVEPEGLDVTEIYPNGISTSLPFDVQLALVRSIRGFAQAHITRPGYAIEYDFFDPRGLKASLETKAVGGLFFAGQINGTTGYEEAAAQGLLAGLNAARHVQALPAWSPRRDEAYLGVLVDDLITHGTTEPYRMFTSRAEYRLQLREDNADLRLTGVGRAMGLVDDARWARFSSKQEAVQRETARLSALWATPGNALGREVVDTLGVPMSRETNVLDLIKRPELSYAALMRVPTLGPGVDDAQVAEQVEIGVKYAGYLDRQRDEIARQQRHETTPIPEGFDYAGVRGLSMEVQQKLERVRPQSIGQAQRIPGMTPAAISLLLVHLERARRSQVA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMCR8_HUMAN
Sequence: MISAPDVVAFTKEEEYEEEPYNEPALPEEYSVPLFPFASQGANPWSKLSGAKFSRDFILISEFSEQVGPQPLLTIPNDTKVFGTFDLNYFSLRIMSVDYQASFVGHPPGSAYPKLNFVEDSKVVLGDSKEGAFAYVHHLTLYDLEARGFVRPFCMAYISADQHKIMQQFQELSAEFSRASECLKTGNRKAFAGELEKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELASVEKSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRPAYTPKLIKAKSTKCFDKKLKTLEELCDTEYFTQTLAQLSHIEHMFRGDLCYLLTSQIDRALLKQQHITNFLFEDFVEVDDRMVEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKSSVESVLIKMEQELGDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSAINEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPSTPAHTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSHLLASRDISKTSLDNYSDTTSYVSSVASTSSDRIPSAYPAGLSSDRHKKRAGQNALKFIRQYPFAHPAIYSLLSGRTLVVLGEDEAIVRKLVTALAIFVPSYGCYAKPVKHWASSPLHIMDFQKWKLIGLQRVASPAGAGTLHALSRYSRYTSILDLDNKTLRCPLYRGTLVPRLADHRTQIKRGSTYYLHVQSMLTQLCSKAFLYTFCHHLHLPTHDKETEELVASRQMSFLKLTLGLVNEDVRVVQYLAELLKLHYMQESPGTSHPMLRFDYVPSFLYKI
What is the function of this protein?
Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654).  In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531).  The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531).  As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654).  Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531).  In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531).
What are the official names of this protein?
Guanine nucleotide exchange protein SMCR8, Smith-Magenis syndrome chromosomal region candidate gene 8 protein.
What is the protein family that this protein belongs to?
Belongs to the SMCR8 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Presynapse. Postsynapse. Note=Localizes mainly in the cytoplasm.
Protein: PSR2_YEAST
Sequence: MGFIANILCCSSDTSKTHRQRQPPETNHNRNRNRKHSSNKAQTQGRKQKATPNGDKMQYSTPEILLSSSDSGSNAGSKTMQENGNSGNGKLAPLSRDHSNNSYDEEKEYEDYNEGDVEMTEVNNAGEEEEEDDEAKEKQDHVVHEYNVDADRNSSINDEAPPQQGLYQVGQEDMNPQYVASSPDNDLNLIPTTEEDFSDLTHLQPDQYHAPGYDTLLPPKLQEFQQKKCLILDLDETLVHSSFKYMHSADFVLPVEIDDQVHNVYVIKRPGVDEFLNRVSQLYEVVVFTASVSRYANPLLDTLDPNGTIHHRLFREACYNYEGNYIKNLSQIGRPLSETIILDNSPASYIFHPQHAVPISSWFSDTHDNELLDIIPLLEDLSSGNVLDVGSVLDVTI
What is the function of this protein?
Probable phosphatase.  Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2.  Acts through a calcineurin-independent pathway and is functionally redundant with PSR1.  Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.
What are the official names of this protein?
Probable phosphatase PSR2, Plasma membrane sodium response protein 2.
What are the subcellular locations of this protein?
Cell membrane.
Protein: PDXH_BORBR
Sequence: MSVSDLRQSYEKGVLVEEQAAASPFQQFARWFDEAVAARVPEPNAMTLATVNAEGQPSARIVLIKGYDDAGFVFFTNYESRKGLDLDANPRASLLFFWQPLERQVRIEGVIEKVSAAESDEYFHSRPLGSRLGAWASRQSQPITRDELEAREREFRDRYGEHPPRPPHWGGYRLKPNRFEFWQGRPSRLHDRLRYEPDGKQGWTIDRLSP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.