PharMolix/UniProtQA huggingface dataset:
Protein: CPCS1_NOSS1
Sequence: MNIEEFFELSAGKWFSHRTSHHLAFKQSEDGKSDLVIESLAADHPEVIKLCELYEVPASAASCGARVSWNGTMEWDEEKHTGSTVLATVPDVDNPNEGRLLREMGYAEKAPVAGRYKMGDDGALTLTTEYETMWSEERLWFASPNLRMRVSVLKRFGGFSMASFTSEIRMGGSPAAAKAEEAANSASS
What is the function of this protein?
Catalyzes the site-selective attachment of phycocyanobilin (PCB) to 'Cys-82' in CpcB and 'Cys-83' in PecB.  Also able to add PCB to ApcA1, ApcA2, ApcB, ApcD and ApcF, but not PecA.  In vitro can be made to add phycoerythrobilin, a non-physiological substrate, to its target proteins (using genes from Fremyella diplosiphon PCC 7601).  Binds PCB extremely rapidly, followed by a much slower phase of PCB transfer to the apo-acceptor protein.  This suggests that the lyase has a chaperone-like function, and may serve to regulate the manner (possibly the conformation) in which the chromophore is attached to its target rather than to accelerate the rate.
What are the official names of this protein?
Phycocyanobilin lyase CpcS 1, Phycocyanobilin:Cys-beta84-phycobiliprotein lyase CpcS, Phycocyanobilin:Cys-beta84-phycobiliprotein lyase CpcS-III, Phycocyanobilin:Cys-beta84-phycobiliprotein lyase CpeS.
What is the protein family that this protein belongs to?
Belongs to the CpcS/CpeS biliprotein lyase family.
Protein: THII_STAAM
Sequence: MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTIEAMSAAAIKFAQQFEENSTFKIDVKRADKNFPMDTYELQRELGGTVLKQIENVSVNVKRPDHEIRVEVRLDAIYMYEEVVPGSGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGALAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFEKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBD_SHIBS
Sequence: MAQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADEQLPQGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNAASQPVSVSQQEQHTAQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQHPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFVMGAIAGLICSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVIGDVWGLRLWSALGVAFFGWAFITSLQAKRGWMRVVQIILLAAALVSVRPLQDWAFGATHTAQTQTHLNFTQIKTVDELNHALVEAKGKPVMLDLYADWCVACKEFEKYTFSDPQVQKALADTVLLQANITANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLRDRQP
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RRAAH_COREF
Sequence: MTDTHGTFIPTADLVDIIGDDVRSCDTQFRNLGGRTDFHGTITTVKCFQDNALLKSILGEDNPGGVLVIDGDASLHTALVGDIIAGLGRDHGWSGVVVNGAIRDSAVIGEMEFGCKALGTNPRKSSKTGAGERDVVVSFGGVDFTPGHYLYADSDGIVVTENPVKAPASN
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: RL20_PROMP
Sequence: MARVKRGNIARKRRNKILNLAKGFRGGNKNLFRTANQRVMKALCNAYRDRRRRKRDFRRLWISRINASARINGTNYSRLINGMKNSEIIINRKMLAQLALSDPQCFEKIVSTVNN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NDUS7_TRYBB
Sequence: MLRRTSFNFTGRAMISRGSPEWSHRLDLKKGKKTTMMHKLGTSKPNNALQYAQMTLHDLTEWCLAYSPWPLTFGLACCAVEMMHAYASRYDLDRFGIVPRPTPRQAEIIIVSGTVTNKMAPILRNIYVQMVNPKWVISMGSCANGGGYYHFSYAVLRGCERAIPVDFWIPGCPPSAESLVFCLHTLQKKIRWHEIQKYSVRD
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, Complex I-20kD, CI-20kD, NADH-ubiquinone oxidoreductase 20 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DAPD_MYCBO
Sequence: MSTVTGAAGIGLATLAADGSVLDTWFPAPELTESGTSATSRLAVSDVPVELAALIGRDDDRRTETIAVRTVIGSLDDVAADPYDAYLRLHLLSHRLVAPHGLNAGGLFGVLTNVVWTNHGPCAIDGFEAVRARLRRRGPVTVYGVDKFPRMVDYVVPTGVRIADADRVRLGAHLAPGTTVMHEGFVNYNAGTLGASMVEGRISAGVVVGDGSDVGGGASIMGTLSGGGTHVISIGKRCLLGANSGLGISLGDDCVVEAGLYVTAGTRVTMPDSNSVKARELSGSSNLLFRRNSVSGAVEVLARDGQGIALNEDLHAN
What is the function of this protein?
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_CLOK5
Sequence: MSIISMKQLLESGVHFGHQTRRWNPKMASYIFTERNGIYIIDLQKTVRKIEEAYEFVKKIASEGKDILFIGTKKQAQEAIKEEAKRSNMHYVNNRWLGGMLTNFLTIRNRIGKLEELEKMEEDGTFEVLSKKEVIKLRNEKQKLERNLGGIKAMNAENVGALFVVDPRKEKNAISEAKILGIPVVAIVDTNCDPDEVDYVIPGNDDAIRAVKLITSKVADAVIEGRQGEQLAEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PTX3_MOUSE
Sequence: MHLPAILLCALWSAVVAETSDDYELMYVNLDNEIDNGLHPTEDPTPCDCRQEHSEWDKLFIMLENSQMREGMLLQATDDVLRGELQRLRAELGRLAGGMARPCAAGGPADARLVRALEPLLQESRDASLRLARLEDAEARRPEATVPGLGAVLEELRRTRADLSAVQSWVARHWLPAGCETAIFFPMRSKKIFGSVHPVRPMKLESFSTCIWVKATDVLNKTILFSYGTKWNPYEIQLYLSSQSLVLVVGGKENKLAADTVVSLGRWSHLCGTWSSEQGSMSLWANGELVATTVEMAKSHSVPEGGLLQIGQEKNGCCVGGGFDESLAFSGRITGFNIWDRVLSEEEIRASGGVESCHIRGNVVGWGVTEIQAHGGAQYVS
What is the function of this protein?
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
What are the official names of this protein?
Pentraxin-related protein PTX3, Pentaxin-related protein PTX3, Tumor necrosis factor-inducible gene 14 protein, TSG-14.
What are the subcellular locations of this protein?
Secreted.
Protein: LACB_STAA9
Sequence: MKIALGCDHIVTDTKMRVSEFLKSKGHEVIDVGTYDFTRTHYPIFGKKVGEQVVSGNADLGVCICGTGVGINNAVNKVPGVRSALVRDMTSALYAKEELNANVIGFGGRIIGELLMCDIIDAFINAEYKATEENKKLIAKIKHLETSNADQADPHFFDEFLEKWDRGEYHD
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacB.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: RL21_SYNJB
Sequence: MTYAIVETGGKQLWVEPGRFYEVDRLAEVEENSPFDLSRVLLINHEGQITLGHPYVSEAVVRARVLQHRRGDKIIVYKMRPKKKTRKKRGHRQPLTRLLIESIELNGVPLATAPSRTEAAPESNPEAAPSAAATGIPADEE
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: QUEC1_RHILO
Sequence: MNALVICSGGLDSVSLAHKVATEQKLIGLLSFDYGQRHKKELGFAAICAKRLAVPHQIVDIRDVGRNLSGSALTDNVDVPDGHYAEDSMRITVVPNRNAIMLAIAFGVAAAKKADAVATAVHGGDHFIYPDCRPAFIDAFQTMQNHALAGYADIRLYAPYVNMSKADIVSEGAKYATPFEATWSCYKGGARHCGRCGTCVERREAFDLAGITDPTDYEDADFWLHAIQTRSA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase 1, 7-cyano-7-carbaguanine synthase 1, PreQ(0) synthase 1, Queuosine biosynthesis protein QueC 1.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: BANP_MOUSE
Sequence: MMSEQDLADVVQIAVEDLSPDHPVVLENHVVTDDDEPALKRQRLEINCQDPSIKSFLYSINQTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCVVPQTTVILNNDRQNAIVAKMEDPLSNRAPDSLENIISNAVPGRRQNTIVVKVPGQDDSHNEDGESGSEASDSVSNCGQPGSQNIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPSSSSYSASETMMGTPPPTSELQQSQPQALHYALANAQQVQIHQIGEDGQVQVIPQGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQSWGLCQNPIPVSGDSVAQANPSQLWPLGGDTLDLPAGNEMIQVLQGAQLIAVASSDPAATGVDGSPLQGSDIQVQYVQLAPVSDHTAAAQTAEALQPTLQPDMQLEHGAIQIQ
What is the function of this protein?
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function.  Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer.  Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels.  Promotes TP53 activation, which causes cell cycle arrest and inhibits tumor growth (PubMed:12494467).
What are the official names of this protein?
Protein BANP, Btg3-associated nuclear protein, Scaffold/matrix-associated region-1-binding protein.
What is the protein family that this protein belongs to?
Belongs to the BANP/SMAR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ORN_FRATT
Sequence: MQSADNLIWIDLEMTGLDVDSCKITEIAAIITDKDLNIIAEAEPIAIYQPDEVLANMNEWCIKTHTETGLTQRVKDSKISTEAAEQQILEFIRKFVPYQSSPLCGNSIWQDRRFLAKYMPNIDEYCHYRMLDVTTLKLLNQYWGDGKSFEKKNTHKALDDIRESIAELKFYRQKLLSI
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_DESPS
Sequence: MKHEILLLGKIKDSFIAEGVEEYLKRLQHYTKVELRYLKGKGKKGALLSTEQEGELLLANVPANAFVVALDVQGKNLSSEGLAEQVINWENTGTRSVCYLIGGPLGLSPSLLARADLRLSFSKMTFTHDMVRLLLVEQLYRAYTIKAGEKYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_CUTAK
Sequence: MAIPSFVDRATLTAVAGKGGHGCASVKREKFKPLGGPDGGNGGHGGSVILRVDPQVTTLVDYHWQSTRKATNGESGRGDNQAGANGSDMILAVPEGTVVSDADTGELLGDLVGVGAELVVAAGGRGGLGNAALANSARKAPGFALLGEAGEERKILLELKVVADIGLVGFPSAGKSSLIAAISRAKPKIADYPFTTLVPNLGVVVAGETTYTVADVPGLIPGASVGKGLGFDFLRHIERCRAIVHVIDCATYEPGRDPVSDLDVIEGELIAHGGLEDRPRLVVLNKVDVPDAADLADIIFDDVAERGWPVSRVSTKSGEGLNSLKFAMAELVEKARDNEPEPEPERIVIRPEPKNERQAFSIKRQGDGEGGFLWRVTGDKPTRWVAQTDFNNPEAVGYLSDRLNRLGVEEELLAMGAIAGDAVAVGGEDAVIFDFAPQIESGAELLSRRGEDQRLKSERPSATRRREMDREYHRAREEYGQVGRDLRGESWRARVAEEEWFEGRD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_AZOVD
Sequence: MRLRLIAVGSRMPRWVEEGWHEYARRLPPELALELLEIPLHTRSKNADVARLIRQEGEAMLGKVQPGERIVTLEVAGKSWSTEQLAAELERWRLDARTVNLMVGGPEGLAPEVCARSEQRWSLSPLTLPHPLVRILIGEQLYRAWTLLSGHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_LIGS1
Sequence: MTTKGILGKKVGMTQVFTENGELVPVTVVKVDSNVVLQVKTMENDGYEAIQLGFDDLREVLTNKPAKGHAAKANTTPKRFVREIRDVELGEYKVGDEVKADIFEAGDFVDVTGTSKGHGFQGSIKRNGQHRGPMAHGSRYHRRPGSMGVIINRVMKGKLLPGRMGGNRVTIQNLEIVKADTENGVLLIKGNVPGANKSLVTIKSTVK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: CADH1_CANLF
Sequence: MGPRYGGAPALLLPLLLLLQVSSGLCQEPEPCRPGFGADSYTFTVPRRHLERGRVLGRVSFEGCTGLPRTAYVSDDTRFKVGTDGVITVKRPLQLHKPEISFLVHAWDSSRRKLSTRVRLKAATHHHHHHHDAPSKTQTEVLTFPSSQHGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNRDKEIKVFYSITGQGADAPPVGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSSNGNAVEDPMEIVITVTDQNDNKPEFTQAVFQGSVTEGALPGTSVMQVTATDADDDVNTYNAAIAYSILTQDPLLPSSMMFTINKDTGVISVLTTGLDREGVPMYTLVVQAADLQGEGLTTTATAVITVTDINDNPPIFNPTTYQGRVPENKANVEIAVLKVTDADVPDTPAWRAVYTILNNNNDQFVVTTDPVTNDGILKTTKGLDFEDKQQYVLYVTVVNVTPFEVILSTSTATVTVDVEDVNEAPIFIPCPKVVSIPEDFGVGQEITSYTAEDPDTYMEQRITYRIWRDAAGWLEVNPESGAIFTRAELDREDFEHVKNSTYEALIIAIDNGSPVATGTGTLLLVLSDVNDNGPIPEPRNMDFCQKNPQPHVINIIDPDLPPNTSPFTAELTHGASVNWTIEYNDPARESLILKPKKTLELGDYKINLKLTDNQNKDQVTTLDVFVCDCEGVVNSCKRTAPYAEAGLQVPAILGILGGILALLILILLLLLFVRRRRVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLLSVPQYRPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD
What is the function of this protein?
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors.  Has a strong inhibitory effect on APP C99 and C83 production.
What are the official names of this protein?
Cadherin-1, Epithelial cadherin, E-cadherin, Uvomorulin.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell membrane; Single- pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane (By similarity).
Protein: FCG3A_MACMU
Sequence: MWQLLLPTALLLLVSAGMRAEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTRWFHNESLISSQTSSYFIAAARVNNSGEYRCQTSLSTLSDPVQLEVHIGWLLLQAPRWVFKEEESIHLRCHSWKNTLLHKVTYLQNGKGRKYFHQNSDFYIPKATLKDSGSYFCRGLIGSKNVSSETVNITITQDLAVSSISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKKSVPSSTRDWEDHKFKWSKDPQDK
What is the function of this protein?
Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG).  Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC).  Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (PubMed:33208458).  Mediates IgG effector functions on natural killer (NK) cells.  Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation.  Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC.  Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity).  Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes.  Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation.  The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (By similarity).  Costimulates NK cells and trigger lysis of target cells independently of IgG binding (By similarity).  Mediates the antitumor activities of therapeutic antibodies.  Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity).  Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821).
What are the official names of this protein?
Low affinity immunoglobulin gamma Fc region receptor III-A, IgG Fc receptor III-A, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcgammaRIIIa.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Secreted. Note=Exists also as a soluble receptor.
Protein: RK121_ARATH
Sequence: MASTTLSIATTIRSSSYPTLASINHFPSRTTTIEFPSRFGGGSSSTLTHRATHLRPIAAVEAPEKIEKIGSEISSLTLEEARILVDYLQDKFGVSPLSLAPAAAAVAAPADGGAAAVVEEQTEFDVVINEVPSSSRIAVIKAVRALTSLALKEAKELIEGLPKKFKEGITKDEAEEAKKTLEEAGAKVSIA
What are the official names of this protein?
50S ribosomal protein L12-1, chloroplastic, CL12-A.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL10_DESPS
Sequence: MNRDDKAALVSQLNDSFGRAKLSVVADYCGLKVSELQQIRIELKGCDSEIRVAKNTLLKRAADGTGTAVLADDFTGTTAVITSYSDPVGPAKVLTQFAGGHEKFVIRSAALEGEKIGVDRLEALAKLPSREVLLGQLLSTWNNVPTGLVRVLSGVPRTFVYGLQALKDQKEQEGK
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: HMPT_LACLM
Sequence: MKLMDNKNIKKLTLLAIWTALTFVLGRLFTFPIPGSAGNILTLLDVGIYTAVFLFGKREAAIIGGFAAFLLDLTAGFSNYMFFSLIIHGGQGYLAGLTRYKWLNFLLSLLVMVGGYFIVGGLMYGWGSAIAGLWVNIVQVIVGFVLAKVLSPLIERTGILNGFRKA
What is the function of this protein?
Probably a thiamine precursor-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.  The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
What are the official names of this protein?
Thiamine precursor transporter HmpT, Thiamine precursor ECF transporter S component HmpT.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LIPB_ACIAC
Sequence: MQVRMLGRVDLRETVEAMQAFTAQRTGDTPDVLWVCEHAPHFTQGLAGHADHLLAPGDIPVVATNRGGQVTFHGPGQVVAYPLVDLRRAGYYVKEYVHRVEEAAIRTLAHFGVTGHRVAGAPGIYVRLDDPRSHALLPQRPRKADPLEPAAAVPDFTGLGKIAALGIKVSRHCTYHGVALNVDMDLEPFSRINPCGYAGLPTVDLSTIGVHTTWDEAASVLASQLAIRLAP
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_RHOE4
Sequence: MPPKSRSTGPKKTQKTRRRDKKNIPHGAAHIKSTFNNTIVSITDPAGNVISWASSGHVGFKGSRKSTPFAAQLAAESAARKAQEHGVKKVDVFVKGPGSGRETAIRSLQAAGLEVGTISDVTPQPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: Y6598_BACAN
Sequence: MLFMLDEIMTPREACDRWGITQEALRMKLKRGKDSELVDKLIREGKLKYYRPIEKKRGEWILTVEAMKILFPKSNRSFIIK
What are the official names of this protein?
Uncharacterized protein pXO2-72/BXB0098/GBAA_pXO2_0098.
Protein: ACPS_STRS7
Sequence: MIVGHGIDLQDISAIEKVYLRNARFARKVLTDKELALFEQFSHHRKMTYLAGRWAGKEAFSKAMGTGIGQLTFQDIEIINDSKGRPVITKSPFQGKAFISISHSGGYVQASVILEDLA
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.