PharMolix/UniProtQA huggingface dataset:
Protein: NUOB_ECO57
Sequence: MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLNDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIGKERRPLSWVVGDQGVYRANMQSERERKRGERIAVTNLRTPDEI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B, NUO2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATP6_BRUA2
Sequence: MANDPIHQFQVSRWIPIDVGGVDLSFTNVSAFMVATVVLASGFLYLTSSGRGLIPTRLQSVSEMAYEFVATSLRDSAGSKGMKFFPFVFSLFMFVLVANFIGLFPYFYTVTSQIIVTFALSLLVIGTVIFYGFFKHGFGFLKLFVPSGVPGIIVPLVVLIEIISFLSRPISLSVRLFANMLAGHITLKVFAGFVVSLSSLGALGIGGAVLPLLMTVAITALEFLVAFLQAYVFTVLTCMYINDAVHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSPC_ELECI
Sequence: FCGSKPRCRPRCKPRCRSRSKKRCRRCRRRCSRIVKKCCRRRSKCCRRRRRCPCPCPRKKLRCCKRRPKRRCPKRKKKRCRRKC
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.  This protamine condenses spermiogenic chromatin in a pattern which comprises fibers with a progressively larger diameter and lamellae that finally undergo definitive coalescence.
What are the official names of this protein?
Cysteine-rich protamine.
Protein: Y029_BORRA
Sequence: MSGHSKWSTIKRKKGTLDAKRNKIFTKLIREISIAARMGGGDIDSNPRLRLAVNKARVANMPKDNIEKAIKKGIGDNMGSEYFKLTYEAYALYGVALIIKCLTDNKNRTASEVRSVLSKSGGSLGAPGSVSYMFHKKGLISYNLDKYHEDEIIELALEAGAEDIYSEGSQVEVITSADNFESVSSILRTKFEEDIAEVALVPESKVALDKEQMDKVLAIIEKLEDCDDVQEVYHNLEIVDDIC
What are the official names of this protein?
Probable transcriptional regulatory protein BRE_29.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EI2BE_RABIT
Sequence: MATTVVAPPGAVSDRANKRGGGPGGGGGGGGARGAEEESPPPLQAVLVADSFNRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLQKSKWCRPTSLNVVRIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVVSNINVTRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDNVVVAVDSATNRILHFQKTQGLRRFSFPLSLFQGSGAGVEIRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTTREYGARVSNLHMYSAVCADVIRRWVYPLTPEANFTDSTAQSCTHSRHNIYRGPEVSLGHGSILEENVLLGSGTVIGSNCSITNSVIGPGCCIGDNVVLDRAYLWKGVQVASGAQIHQSLLCDHAEVKEQVTLKPHCVLTSQVVVGPNITLPEGSVISLHPPDAEEDEDDGQFSDDSGVNQAKEKAKLKGYNPAEVGVAGKGYLWKAADMNTEKEEELRQSLWGLTINEEEESETESERSMDSEELDSRAGSPQLDDIKVFQNEVLGTLQRGKEESISCDNLILEINSLKYAYNISLKEVMQVLSHVVLEFPLQQMDSPLEANRYCALLLPLLKAWSPVFRNYIKRAADHLEALAAIEEFFLEHEALGTCIAKVLMGFYQLEILAEETILSWFGQRDVTDKGRQLRKNQQLQRFIQWLKEAEEESSEDD
What is the function of this protein?
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
What are the official names of this protein?
Translation initiation factor eIF-2B subunit epsilon, eIF-2B GDP-GTP exchange factor subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B gamma/epsilon subunits family.
Protein: CRCB1_CARHZ
Sequence: MVDLLLIGLGGSIGAILRYTLTKKIGERYQGDWPLATFLINIIGSFGLGLLYGFKLNQVIWLLLGTGFFGGFTTFSTYIYEAIFLMEEGLFWKNVNYLLTSIFTGVVFFAAGMWLANFFKGGV
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CYSH_ECOL6
Sequence: MSKLDLNALNELPKVDRILALAETNAQLEKLDAEGRVAWALDNLPGEYVLSSSFGIQAAVSLHLVNQIRPDIPVILTDTGYLFPETYRFIDELTDKLKLNLKVYRATESAAWQEARYGKLWEQGVEGIEKYNDINKVEPMNRALKELNAQTWFAGLRREQSGSRANLPVLAIQRGVFKVLPIIDWDNRTIYQYLQKHGLKYHPLWDEGYLSVGDTHTTRKWEPGMAEEETRFFGLKRECGLHEG
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_MYCSS
Sequence: MSVLLFGVSHRSAPVSVLEQLSTDESDQAKIVDQVLQSSLVTEAMVLSTCNRVEVYAVVDAFHGGLSVIGQVLAEHCGMSLNDLTKYAYVRYAEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYTSAEANHTVGRTLHELSQRALSVGKRVHSETGIDAAGASVVSVALDIAEAKLGSLAGRTAVVIGAGSMGALSAKHLVRAGIERVHVVNRSLPRARRLAQSLLDQGVTADAHTLDDIAHALADADVVITSTGAVRPVVSLADAHRGLTGRPEHRRLVICDLGMPRDVEPAIAGLPGVNVIDMERIQREPSARAAASDADAARSIVAAEVANYLAGQRMAEVTPTVTALRQRAADVVEAELLRLDNRLPELDAAHRAEVAKTVRRVVDKLLHAPTVRVKQLASAPGGDSYAEALRELFELDQQAVDAVAAGELPLLPIELDKSE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PB1F2_I78AC
Sequence: MEREQDTPWTRSTEHTNIQKRENGQPTQKLGRPNLIQLMDHYLRIMNQVDMHKQTAFWKQWLSLKNPTQESLKTRVLKRWRLFNRQGWTS
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: PAN1_ASPFU
Sequence: MYSSSNSFLGGVNNARPGQPPFMQQPPYSQLPQGQQQIPQQTGFQPQPTGYGSQSASHLQPQPTGFPTGQLQPQFTGFPGAAPPQQQQQFGGYQAPAQQPQLTGYPPQSQPPSLQVPSTTGLPTRLAPRTSSEIANSFSDGAGVAPPPPPKSSGSKIPNIRLSFITAQDQAKFEQLFKSAVGDSQTMDGEKAKELLLRSRLPGSELSKIWVLSDTTKSGQLFFPEFALAMYLCNLRITGRELPSTLPDKIKNEVSGMVDIISFGVPDTEPQGAARTNVPSFDAPLLENKSAPPAPQHPKPQQPSNAQFLSQLAAQPTGFGPQATGLQPNQPSLLGANATLAPQTTGFPGQSQQQYLHSQPTGLMTNPQATGYNGPRPPLPPMPTGFGSNLSSMQTGGLAAQPTGIPGQWGFVNAPSSGLPNIEALKQQLMPQPGREGGFTTAGLSGNASIPWAITKEEKKIYDDLFRAWDGLHKGFIGGDTAIEIMGQSGLDRKDLERIWTLADPSNRGRLNMDEFAVAMHLIYRKLNGYPVPNRLPPELIPPSTRNLNDSIGAVKSLLSQDAESRKASGAFLQPQKTGVSYLKEHSFRGGARSPGFGRKDATLFKNNDEAAAGYRSSARRRVGNDARPSSPPTSQASEEELSVEQLKKKIRETQIMLDAVDFKDENRAEEDEVLDRRDRLEAESLMDRTRRVQDDIDTHPNAVFRKLDNGAERRSLRRQLQAFEDQVPQIASEVRRIEREIADAKLELFRLKDAKAHPNSAANIVGTGPGGTVTEADRIKARARARMQARAAELAGRPVPASVDDDGAAVRRLEAESASIRADREKNEAMTRDVEESVREFTRSLEDSLKEEGETSTREHERRRWEDALGVEDVIRDFIYDLQRGSRTAHIRKEEESRASAQEQRLRHEEPSPGVSRLSPAPSAGSAGSLPGSTHEDRVAAARERAQRRIAERMAAAGLKPHTDTSETLLQRQEREKREREERLRRAEEEDAKREQERQRRLAEEQRSTSDTPAKPVGKKPPPAPPSRRGRTDSAGQAEVKKAAEETITAEQAAREQAIREEQQAQEEETNRLEMEAQKREEELLKEKEAQEARLRALEEQVRQGKIRKQEEKRRKEEAERLAKEKEAALAAQRAEIERAKERERQLQLELERLDEESSSDDEGPVNITPEDSTPTQSQLLPTVTPAAPVSAPESEQAGSPEDTSSQAPPVDFKLETESKNPYFKITHQATDTQVVSSPPVPQPSFTSPKADVHSTNPFHRLAKQETSKPAFTGSAPLERKSRARPEADDDWSAAGSEFDSSDDDDDERPGGGSAKQLASILFGTMAPPRPLSAMDDKSPSKSSTPVQDSPVASLPVPESNGSLSAPAAPPPPPPPPPAAVPSYDPSVAPPPPPAPPMAPPAPPPGPPPPPGPLPPPAPPAASGPPTPAGAPDRSALLASIQKGKGLRKVQTNDRSTSSIAGRVLD
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein pan1.
What is the protein family that this protein belongs to?
Belongs to the PAN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: EFTS_BORT9
Sequence: MSISPQEVKKLRDVTGAGFGDCKKALDAVGGDFELAKKKLREMGIASADKRSGRDAKEGRVFSYVNKERVGLLLISCETDFVAMNSDFVTFGNSLIKQLVESGKDSLDKQQELEIKNLAATIKENIHVSKIYISNIASNELVKNYLHGEQSKIGVFIKLKVDDVLKMEDESLNNLAMDLALHVAAFAPLYLSVGDICSNYIKEQEEMFTKQMEASGKSEAVIKGIVSGKLKKHLGEIALLEQGFVKDDKLTVKEKIEEISKSILTKIEIVDFKYLSVG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_THISH
Sequence: MDKKSARLRRAARTRHQIRHNGVHRLCVHRTPRHIYAQVIAPNGSEVVAAASTVEVELAKDLKGTGNVDAAVAIGKVIAERAKAKGVSEVAFDRSGFKYHGRVKALADAAREGGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TBWKD_DROME
Sequence: MATAPRSLDTISLCSTVSSCPDRNGFYGGFQRTDKPKEPLSKAQIIAREKKWLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVYLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRLNLRVEDFQIEHTRQKARRAKQKAQQEAESSGSGNGHRRNMPTL
What is the function of this protein?
Essential for ensuring the polarized growth of tracheal seamless tubes.  During seamless tube morphogenesis, likely to act as a GTPase-activating protein (GAP) for Rab35 to regulate vesicle trafficking from the recycling endosomes to the lumenal apical membrane to ensure the polarized dynein motor complex-dependent growth of seamless tubes along the proximodistal axis in tracheal terminal cells.  When the terminal branch lumen is growing, Rab35-GTP is active and likely directs the transport of apical membrane vesicles from the soma to the distal tip of elongating terminal cell branches thus providing a continuous supply of apical membrane components as the lumen grows.  Whereas when Rab35-GDP is inactivated, presumably by this GAP, apical membrane vesicles are transported to a central location adjacent to the terminal cell nucleus.
What are the official names of this protein?
TBC1 domain family member whacked.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Cell projection, filopodium. Note=Restricted to the lumenal membrane of tracheal terminal cells with increased accumulation at the growing tips of seamless tubes. Colocalizes with Rab35 at the apical membrane, cytoplasmic puncta (likely to be vesicles) and filopodia.
Protein: UBIG_BURCJ
Sequence: MTNADPHELQKFSDLAHRWWDPNAEFKPLHDLNPVRLGWIDAHAHLAGKRALDIGCGGGILSESMAGLGAQVKGIDLSTEALGVADLHSLESGISVDYEAIAAEAIAAREPGTYDVVTCMEMLEHVPSPGDVVAACATLVKPGGWVFFSTLNRNLKSYLFAVIGAEYIAQMLPKGTHDYARFIRPSELAGFVRATDLHIVEIKGITYHPIGKRFALSNDTDINYLVACRRGA
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: AIG1_MOUSE
Sequence: MALVPCQVLRVAILLSYCSILCNYKAIEMPSHQTYGGSWKFLTFIDLVIQAVFFGICVLTDLSSLLTRGSGNQEQERQLRKLISLRDWTLAVLAFPVGVFVVAVFWTIYAYDREMIYPRLLDNFIPGWLNHGMHTTVLPFILIEMRTSHHQYPSRSSGLAAICTFSVGYILWVCWIHHVTGMWVYPFLEHIGSGARIIFFGSTTILMNFLYLLGEVLNSYIWDTQRSIEEEKEKPKLE
What is the function of this protein?
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (By similarity).  Shows a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (By similarity).
What are the official names of this protein?
Androgen-induced gene 1 protein, AIG-1, Fatty acid esters of hydroxy fatty acids hydrolase AIG1, FAHFA hydrolase AIG1.
What is the protein family that this protein belongs to?
Belongs to the AIG1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEUD_BUCRP
Sequence: MFKFTEHNGVVAPLNISNIDTDAIIPKQFLQKVNKIGFGKYLFHDWRFIDKNQLKINPNFILNNYVYKNASILLTRENFGCGSSREHAVWSLLDYGFKVIISSSFSDIFFNNSFNNKLLLVVLEKKHIDYLFNLVDTKIGISFNVSLINKKITAGDLDIPFQIDDFQRLCLLNNWDNIDLTMKINHKIKSYEDNISSFLLERQEFTS
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: SYRC_ARATH
Sequence: MATIVASKEFTGNPRRQLAKLFDVSLKLTVPDEPNVEPLIEPGKFGDYQCNNAMGLWSLIKGKGTQFRGPPAVGQALIQSLPTSEMVESCSIAGPGFVNVVLSSKWMAKSIENMLVDGIDTWAPTLSVKRAVVDFSSPNIAKEMHVGHLRSTIIGDTLARMLEYSKVEVLRRNHVGDWGTQFGMLIEFLFEKFPDTESVTETAIGDLQVFYRESKLKFDLNPEFKEKAQQAVVRLQGGDPVYRQAWAKICEISRNEFAKVYKRLRIELEEKGESFYNPYIANVIEELSSKGLVEESKGARVIFIEGFKIPLIVVKSDGGFNYASTDLTALWYRLNEEKAEWIIYVTDVGQQQHFDMFFKAARKAGWLPDDDKTYPRVSHVGFGLVLGDDNKRFRTRAAEVVRLADLLDEAKDRSKAALIERGKDKEWSPEELDQIAEAVGYGALKYADLKTNRITGYTFSFDQMLNDKGDTAVYLLYAHARICSIIRKSGKDIDELKKTGKIALDHAAERALGLHLLQFAETVEEACTTLLPNVLCKYLYYLSEEFTKFYSNCQVNGSAEETSRLLLCEATAIVMRKCFHLLGITPVYKL
What is the function of this protein?
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.
What are the official names of this protein?
Arginine--tRNA ligase, cytoplasmic, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: COBT_LEPIC
Sequence: MNPDQLSTKLQNKIDLKTKPPGSLGTLESIALQIGLIQNTDSPELKNPHILVFAGDHGLAESGVSAFPKEVTHQMVFNFLNGGAAINAFCKQNSIRLKVVDSGVDFKFPHDTVSLHPDFIDAKVGFGTKNILIEPAMTKEQCNQALENGARISQKSVSENCNVIGFGEMGIGNTSSASLITASILKKSLKEVTGKGTGLNDQGFQKKIEILEKCFEKHKTNLKTAFDVLQTFGGFEIAMMVGAMIDSVKKGRIILIDGFIATSAFLIAHKMEPSILKNAVFCHKSVEPGHSYLLEEWNIKPLLDLGLRLGEGTGCAIAFPILISAVTFLKEMASFESAKVDQKL
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: NANO3_DANRE
Sequence: MAFSLLQFILSAHGSMETRNQDFQPWKDYMGLADMIRGMKRQEMQSDADSDEQAAALLESPSGPIRSRDSPEQNTSPGGGKPKSSPAERKFCSFCKHNGETEAVYTSHYLKNRDGDVMCPYLRQYKCPLCGATGAKAHTKRFCPMVDKNYCSVYAKSTW
What is the function of this protein?
RNA-binding protein which binds to RNA with no sequence specificity (PubMed:20948543).  Probably represses translation of specific mRNAs (By similarity).  Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival but is not required for PGC specification (PubMed:11691838, PubMed:17418113).  Also required to maintain oocyte production in the adult ovary (PubMed:17418113, PubMed:23228893).  Negatively regulates phosphorylation of myosin mylpfa/mylz2 (PubMed:20673786).
What are the official names of this protein?
Nanos homolog 3.
What is the protein family that this protein belongs to?
Belongs to the nanos family.
Protein: CASP1_DROME
Sequence: MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGATAASPLPANKFVARMPVERYASEYNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDCKLRDILKHVGKAAELDHTDNDCLAVAILSHGEHGYLYAKDTQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQGDRLDGGITLEKGVTETDGESSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVALDFESNVPATPMMDRQKQIPCLTSMLTRILRFGDKPNGNKAG
What is the function of this protein?
Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity).  Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).  Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors.
What are the official names of this protein?
Caspase-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
Protein: IF2_STRAG
Sequence: MSKKRLHEIAKEIGKTSKEVVEQAQSLGLPVKSHASSVEENDATRIVESFSSSKTKAPTNSVQTNQGVKTESKTVETKQGLSDDKPSTQPVAKPKPQSRNFKAEREARAKAEAEKRQHNGDHRKNNRHNDTRSDDRRHQGQKRSNGNRNDNRQGQQNNRNKNDGRYADHKQKPQTRPQQPAGNRIDFKARAAALKAEQNAEYSRHSEQRFREEQEAKRQAAKEQELAKAAALKAQEEAQKAKEKLASKPVAKVKEIVNKVAATPSQTADSRRKKQTRSDKSRQFSNENEDGQKQTKNKKNWNNQNQVRNQRNSNWNHNKKNKKGKTNGAPKPVTERKFHELPKEFEYTEGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGDTIELLMVDYGIEAHAKVEVDEADIERFFADEDYLNPDNLTERPPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIEEAGKKITFLDTPGHAAFTSMRARGASVTDITILIVAADDGVMPQTVEAINHSKAAGVPIIVAINKIDKPGANPERVISELAEHGVISTAWGGESEFVEISAKFGKNIQELLETVLLVAEMEELKADADVRAIGTVIEARLDKGKGAVATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGDHFAVYADEKAARAAGEERAKRALLKQRQNTQRVSLENLFDTLKAGEVKSVNVIIKADVQGSVEALAASLLKIDVEGVKVNVVHSAVGAINESDVTLAEASNAVIIGFNVRPTPQARQQADADDVEIRQHSIIYKVIEEVEEAMKGKLDPEYQEKILGEAIIRETFKVSKVGTIGGFMVINGKVTRDSSVRVIRDGVVIFDGKLASLKHYKDDVKEVGNAQEGGLMIENYNDLKEDDTIEAYIMEEIKRK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_STAAN
Sequence: MSKIIGIDLGTTNSCVTVLEGDEPKVIQNPEGSRTTPSVVAFKNGETQVGEVAKRQAITNPNTVQSIKRHMGTDYKVDIEGKSYTPQEISAMILQNLKNTAESYLGEKVDKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDKDEKVLVFDLGGGTFDVSILELGDGVFEVLSTAGDNKLGGDDFDQVIIDYLVAEFKKENGVDLSQDKMALQRLKDAAEKAKKDLSGVSQTQISLPFISAGENGPLHLEVNLTRSKFEELSDSLIRRTMEPTRQAMKDAGLTNSDIDEVILVGGSTRIPAVQEAVKKEIGKEPNKGVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIEILGGRMNTLIERNTTIPTSKSQIYSTAVDNQPSVDVHVLQGERPMAADNKTLGRFQLTDIPPAERGKPQIEVTFDIDKNGIVNVTAKDLGTNKEQRITIQSSSSLSDEEIDRMVKDAEVNAEADKKRREEVDLRNEADSLVFQVEKTLTDLGENIGEEDKKSAEEKKDALKTALEGQDIEDIKSKKEELEKVIQELSAKVYEQAAQQQQQAQGANAGQNNDSTVEDAEFKEVKDDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PETG_CROS5
Sequence: MIEPLLLGIVLGLIPITLAGLFVAAYLQYKRGNQLNLE
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: HOA2_METPP
Sequence: MSATRSMEPDLRGRKVLLHDMCLRDGMHAKREQIPVEQMVKVAMALDAAGVPLIQVTHGAGLGGNSLQHGFALASNEAYLSAVAPKMKQAKVSVLLIPGLGTMRELQSAYNCGARSVTVATHCTEADTAPQHIAYARKLGMDTVGFLMMAHLNDPEGLAKQGKLMEDYGAQTVYVTDSAGYMLPADVRARVAALRAVLKPETEIGFHGHHNLGMGIANSIAAIEEGASRIDGSVAGLGAGAGNTPLEVFLAVCDRMGIETGVDLFKLMDVAEDVIVPMMDHLVRVDRESLTLGFAGVYSTFLLHAKRAAARFGVPAREILVELGRRKMIGGQEDMIEDTAMSMAKERGLLKDVSRKAA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 2, HOA 2, 4-hydroxy-2-keto-pentanoic acid aldolase 2, 4-hydroxy-2-oxopentanoate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: SYDE1_HUMAN
Sequence: MAEPLLRKTFSRLRGREKLPRKKSDAKERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSSPEASRSPARGAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDPRPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRLSLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPAGPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGEARARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQSWPDPRLPRQSPDVAPYLRPKRQPPLHLPLADPEVVTRPRGRGGPESPPSNRYAGDWSVCGRDFLPCGRDFLSGPDYDHVTGSDSEDEDEEVGEPRVTGDFEDDFDAPFNPHLNLKDFDALILDLERELSKQINVCL
What is the function of this protein?
GTPase activator for the Rho-type GTPases.  As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration.  It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469).
What are the official names of this protein?
Rho GTPase-activating protein SYDE1, Synapse defective protein 1 homolog 1, Protein syd-1 homolog 1.