PharMolix/UniProtQA huggingface dataset:
Protein: 1433Z_DROME
Sequence: MSTVDKEELVQKAKLAEQSERYDDMAQAMKSVTETGVELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEASARKQQLAREYRERVEKELREICYEVLGLLDKYLIPKASNPESKVFYLKMKGDYYRYLAEVATGDARNTVVDDSQTAYQDAFDISKGKMQPTHPIRLGLALNFSVFYYEILNSPDKACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDTQGDEAEPQEGGDN
What is the function of this protein?
Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development (PubMed:9159395).  Acts upstream of Raf and downstream of Ras, and is essential for viability (PubMed:9159395).  Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob (PubMed:10230800).  Inhibits yki activity by restricting its nuclear localization (PubMed:19900439).  Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes (PubMed:27015288).
What are the official names of this protein?
14-3-3 protein zeta, 14-3-3-like protein, Protein Leonardo.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome.
Protein: TPX_STRMU
Sequence: MTTFNGNTVTLAGKKLQVGDTAPDFSLTDTDLSKKTLADFAGQKKVISVVPSIDTGVCDAQTRRFNQELSDADNTVVITVSVDLPFAQARWCGAAGLNDAITLSDYYDYSFGKAYGLLINELHLLGRAVFVLDEDNKITYLEYLDEMTNHPNYDAALAAVK
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: IF2_PROVU
Sequence: MTDETVKSLAEEIQTPVERLVQQFADAGIEKTVSDSVSQKEKETLLAWLNRDKDISTGQPSKLTLQRKVRSTLSVPGTGGKSKSVAIEVRKKRTYVNRDVIEKSQAEEQALREAEEKAHREVEEKAQREAQEKAQRAAEEKAKREAQEAKKQAEEKAKREAEEAKREAAELAKREAAEKNKVKQNDKPKADVADQDKARRNAELAELKRKTEEAQRLKVEEETRAAAEKARRLAEENAEKWTAEPKAPETESADYHVTTSRYARDAEDESDAEVEGDRRRGRTAKAPRAKKNNRHSEKADREEARAAGRSNKKGKRKSSTLQQGFHKPAVAVNRDVIIGETISVAELANKMAVKGSEVIKTMMKMGAMATINQVLDQETAQLVAEEMGHKVILRRENELEEQVMNDRDTGEESEVSRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVKTDKGEITFLDTPGHAAFTSMRARGAQVTDIVVLVVAADDGVMPQTIEAIQHAKAANVPVVVAVNKIDKHEADPDRVKTELSQYGILSEDWGGETQFMHVSAKQGLGIDELLDAILLQAEVLELKAVKEGMASGVVIESYLDKGRGPVATILVREGTLNKGDIVLCGFEYGRIRAMRNELGQEVQSAGPSMPVEILGLSNVPSAGDEATVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMEEGKVSELNIVLKTDVQGTCEAITDALVKLSTDEVKLRIIGSGVGGITETDATLAAASEAIILGFNVRADASARRIIEQESVDLRYYSVIYSLIDEIKLAMSGMLAPEYKQEIMGLAEVRDVFKSPKFGAVAGCMVVEGNIKRNNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRVGDMIEVFQVIEIKRSIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3S13_OXYMI
Sequence: MKTLLLTLVVVTIVCLDLGYTMTCYNQQSSQAKTTTTCSGGVSSCYRKTWSDIRGTIIERGCGCPSVKKGIERICCGTDKCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin 3FTx-Oxy3.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: BAG6_XENTR
Sequence: MEVTVKTLDSQTRTFTVDAEITVKEFKTHISSDVGISPEKQRLIYQGRVLQEDKKLKEYNVDGKVIHLVERAPPQTQPSTGGPSTSSSTSPSSSNAANVPGAGAPERNGNSYVMVGTFNLPHVMSGLGEASRGPRVSTVSGNDGSTLDVHINLDQQLPVQSEPRVRLVLAQQILQDIQRILDRLEGQPVNEQTAEPMDTAVSEGEASSRETLPQTTQNTDGQSNTAPTSHPSPSEYVEVLQSLSRVEERLAPFMQRYREILSSATSDAYENQEEREQSQRIINLVGESLRLLGNALVAVSDLRCNLSSASPRHLHVVRPMSHYTGPMLLQQAAIPIQINVGTTVTMTGNGTHAGQMPSDGNAAHTPTNTSEPQRSNSDNQPPSSGERPASEIPPTSVPHPHPRVVRITHQTVEPVMMMHMNIQDSGPGGPTNIPPPTAGHGGSAHIHMPGLPPEFMQAISHQITQQAVAAASGQQIPGFQAPPRFVFTRPAAPSFPPQPGVATTPPGPGGATTAVPGATVGPAGNASLAQMISGLVGQLLMHPVIVAQGGSNTPSSTSTPTSTSSSSSSSSSTVTTSTTTTSSTSFPTVSSGPSPQPPPGTDQHLSQLLGSLLGTAGSGMSNFAMGSPSITVTVPGMPAFLQGVTDILQATQTVPVSTSPPQSASQAPPPSSPSPPPAHSSPPPAAAPESLPPEFFTSVVQGVLSSMLGSLSAADQSGTESIAAFIQRLSGSHNIFQPDAEGPGGFFGDLLTLICHNFSLVDMVMLLHGHSQPLQNLQPQLRSFFLQEYLHQADPTPNNIQMASRNLTNGLEEYIRESFASVTVRDDVDITRTNLEFLQDQFNRITTHILHCADSTFGQRLLEMCNQSLFEWLALNLYCLRGDQSALTSVINERIRRLSLDVSPVLVSWVTSVLSLRLQVLLGQMPVTEGEIQRHIRRVGDVPQAPEASSQDQPMETTPVDCQNGAASPVPATTVEEVLFLPPQSSVPTICTDSEHPTQEDTGSEQWAASVPPEWVPVIRQDMQNQRKMKQQPPLSDAYLSGMPAKRRKTMQGEGPHLSLSEAVSRAMKATGAKPESSTDCVRRELDNSEAQGRYREQLCQDIQNILQDNESYSAQRFPNTQRAFRGDP
What is the function of this protein?
When nuclear, may also act as a component of some chromatin regulator complex.
What are the official names of this protein?
Large proline-rich protein bag6, BCL2-associated athanogene 6, HLA-B-associated transcript 3.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Secreted, extracellular exosome.
Protein: RECR_GLOC7
Sequence: MFTPPLARLIEQLQRLPGVGPKTAQRLALHILKRPEEEVNTLAKAIVEAKKQVGLCQVCFHLSAESTCEICRNPNRDNQTLCVVADSRDVIALEKTREYQGKYHVLGGVISPMDGIGPEQLNISPLVRRVSQHQIKEVILAISPSVEGETTTLYVGQLLKPFTKVTRIAFGLPMGGDLEYADEVTLARALEGRRELDYN
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: IF1_RHOPA
Sequence: MAKEELIQFEGLVTEILPDARYRVQLDTGHEIVAYTAGKMKKNRIKTLAGDRVTVEMSPYDLEKGRLIFRHKDERPGGPPRSGPPRGQFRRR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRK25_ARATH
Sequence: MSSCFKSSVSLFSVFLFMILKTVTSDPTYLYHICPNTTTYSRNSSYLTNLRTVLSSLSSPNAAYASLFDNAAAGEENDSNRVYGVFLCRGDVSAEICRDCVAFAANETLQRCPREKVAVIWYDECMVRYSNQSIVGQMRIRPGVFLTNKQNITENQVSRFNESLPALLIDVAVKAALSSRKFATEKANFTVFQTIYSLVQCTPDLTNQDCESCLRQVINYLPRCCDRSVGGRVIAPSCSFRYELYPFYNETIAAAPMAPPPSSTVTAPPLNIPSEKGKGKNLTVIVTAIAVPVSVCVLLLGAMCWLLARRRNNKLSAETEDLDEDGITSTETLQFQFSAIEAATNKFSESNKLGHGGFGEVYKGQLITGETVAIKRLSQGSTQGAEEFKNEVDVVAKLQHRNLAKLLGYCLDGEEKILVYEFVPNKSLDYFLFDNEKRRVLDWQRRYKIIEGIARGILYLHRDSRLTIIHRDLKASNILLDADMHPKISDFGMARIFGVDQTQANTKRIVGTYGYMSPEYAIHGKYSVKSDVYSFGVLVLELITGKKNSSFYEEDGLGDLVTYVWKLWVENSPLELVDEAMRGNFQTNEVIRCIHIALLCVQEDSSERPSMDDILVMMNSFTVTLPIPKRSGFLLRTMKDSRDPRSGGSASDHSATSKSLPLSVDDSSITIVYPR
What are the official names of this protein?
Cysteine-rich receptor-like protein kinase 25, Cysteine-rich RLK25.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GLO2_ECOUT
Sequence: MNLNSIPAFDDNYIWVLNDEAGRCLIVDPGDAEPVLNAISANNWQPEAIFLTHHHHDHVGGVKELVEKFPQIVVYGPQETQDKGTTQVVKDGETAFVLGHEFSVIATPGHTLGHICYFSKPYLFCGDTLFSGGCGRLFEGTPSQMYQSIKKLSALPDDTLVCCAHEYTLSNMKFALSILPHDLSINDYYRKVKELRAKNQITLPVILKNERQINVFLRTEDIDLINVINEETLLKQPEERFAWLRSKKDRF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: KITH_STRA3
Sequence: MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDEFGVVSSRIGMRREAVPISDDMDIFSYIQNLPQKPYCVLIDECQFLSKKNVYDLARVVDDLDVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRTENGKPVYEGDQIQIGGNETYIPVCRKHYFNPDI
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSEK3_SALTS
Sequence: MFSRVRGFLSCQNYSHTATPAITLPSSGSANFAGVEYPLLPLDQHTPLLFQWFERNPSRFGENQIPIINTQQNPYLNNIINAAIIEKERTIGVLVDGNFSAGQKKALAKLEKQYENIKVIYNSDLDYSMYDKKLSDIYLENIAKIEAQPANVRDEYLLGEIKKSLNEVLKNNPEESLVSSHDKRLGHVRFDFYRNLFLLKGSNAFLEAGKHGCHHLQPGGGCIYLDADMLLTGKLGTLYLPDGIAVHVSRKGNSMSLENGIIAVNRSEHPALKKGLEIMHSKPYGDPYIDGVCGGLRHYFNCSIRHNYEEFCNFIEFKHEHIFMDTSSLTISSWR
What is the function of this protein?
Protein-arginine N-acetylglucosaminyltransferase effector that disrupts TNF signaling in infected cells, including NF-kappa-B signaling and apoptosis (PubMed:26394407, PubMed:28069818, PubMed:28522607, PubMed:32766249, PubMed:29449376).  Acts by catalyzing the transfer of a single N-acetylglucosamine (GlcNAc) to a conserved arginine residue in the death domain of host proteins such as TRADD, TNFRSF1A/TNFR1 and TNFRSF10B/TRAILR2: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNF-alpha receptor complex, thereby disrupting TNF signaling (PubMed:28069818, PubMed:32766249, PubMed:29449376, PubMed:30902834).  Also acts on host proteins without a death domain: catalyzes arginine GlcNAcylation of host small Rab GTPase (Rab1, Rab5 and Rab11), thereby preventing GTPase activity and leading to impaired host vesicular protein transport (PubMed:32504010, PubMed:32974215).  Also mediates auto-GlcNAcylation, which is required for activity toward death domain-containing host target proteins (PubMed:32432056).
What are the official names of this protein?
Protein-arginine N-acetylglucosaminyltransferase SseK3, Arginine GlcNAcyltransferase SseK3, Salmonella secreted effector K3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase NleB family.
What are the subcellular locations of this protein?
Secreted. Host Golgi apparatus. Note=Secreted via type III secretion system 2 (SPI-2 TTSS) (PubMed:21445262). Localizes to host Golgi apparatus via lipid-binding (PubMed:32504010).
Protein: AZOR_FRAP2
Sequence: MRKILHIRSSIKEENSVSRKIGDDLISHFKSTDKVKVSERDLVDNSVEHINPDFINAMANNNQDRLATSNKLIEELFENDIIAIESPMYNFSIPSTLKSWIDNIMIARKTFLYTANGPEGLVKNKKAILVLSKGNIYSEGAAKPLDFQENYLKTILNFIGINDITVICAEGVDLNAEIREKSLKQVEQQIKNLSI
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: PHO85_CANAX
Sequence: MTGSSSQFQQLEKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIREISLMKELDHENIVTLYDVIHTENKLTLVFEYMDKDLKKYMEVHGQQSALDLKVVKSFMFQLLKGIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEVVTLWYRAPDVLLGSRAYTTSIDIWSAGCIFAEMCTGKPLFPGTANEDQLIKIFRLMGTPNERTWPGISQYTNYKNNWQIFVPQDLRLIVPNLDSMGLNLLQSLLQMRPESRITARQALQHPWFHEITMPNAVPQHLSDPYQQQQQQQQHPHQPIIDQQY
What is the function of this protein?
When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.
What are the official names of this protein?
Negative regulator of the PHO system, CaPHO85, Serine/threonine-protein kinase PHO85.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: OR5M1_HUMAN
Sequence: MFSPNHTIVTEFILLGLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSHLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVITEFYILASMALDRYVAICSPLHYSSRMSKNICVCLVTIPYMYGFLSGFSQSLLTFHLSFCGSLEINHFYCADPPLIMLACSDTRVKKMAMFVVAGFNLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKSVEESKITAVFYTFLSPMLNPLIYSLRNTDVILAMQQMIRGKSFHKIAV
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 5M1, OST050, Olfactory receptor OR11-208.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SAT2_STACB
Sequence: MPSLQVIRAAVAELPQGSSIVAAVAGGTTGIGSYLAKALATTFASHGSKLRVYIVGRNAGRAKTVISECQKISPGSDWRFIHATDLALISEVDKSSAEIIKQETEAPFHGELARLDLLYMTHAIPILGHKRTTEEGLDALESTIYYSRIRFILQLLPLLTASPRVAHVISVYAGGMENGVKPDEEPIGFVPAEIYHFNTVRKYTTFMKTFVFEELAEKYAERLSLIHIYPGLVDGPGFTQMPRWFRVLFTLMKPLTSLYMTRSEDCGMVMAYLATSRFSAKGSGQDAPTSTDTLAPKSSLGVVGGGAYSLGQRADSQTPQIMFEKSRKPDTSKKAWDHTIRTLDDIAKKNATIA
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the satratoxin SC1 cluster involved in the biosynthesis of satratoxins, trichothecene mycotoxins that are associated with human food poisonings (PubMed:25015739).  Satratoxins are suggested to be made by products of multiple gene clusters (SC1, SC2 and SC3) that encode 21 proteins in all, including polyketide synthases, acetyltransferases, and other enzymes expected to modify the trichothecene skeleton (PubMed:25015739).  SC1 encodes 10 proteins, SAT1 to SAT10 (PubMed:25015739).  The largest are SAT8, which encodes a putative polyketide synthase (PKS) with a conventional non-reducing architecture, and SAT10, a putative protein containing four ankyrin repeats and thus may be involved in protein scaffolding (PubMed:25015739).  The putative short-chain reductase SAT3 may assist the PKS in some capacity (PubMed:25015739).  SAT6 contains a secretory lipase domain and acts probably as a trichothecene esterase (PubMed:25015739).  SAT5 encodes a putative acetyltransferase, and so, with SAT6, may affect endogenous protection from toxicity (PubMed:25015739).  The probable transcription factor SAT9 may regulate the expression of the SC1 cluster (PubMed:25015739).  SC2 encodes proteins SAT11 to SAT16, the largest of which encodes the putative reducing PKS SAT13 (PubMed:25015739).  SAT11 is a cytochrome P450 monooxygenase, while SAT14 and SAT16 are probable acetyltransferases (PubMed:25015739).  The SC2 cluster may be regulated by the transcription factor SAT15 (PubMed:25015739).  SC3 is a small cluster that encodes 5 proteins, SAT17 to SAT21 (PubMed:25015739).  SAT21 is a putative MFS-type transporter which may have a role in exporting secondary metabolites (PubMed:25015739).  The four other proteins putatively encoded in SC3 include the taurine hydroxylase-like protein SAT17, the O-methyltransferase SAT18, the acetyltransferase SAT19, and the Cys6-type zinc finger SAT20, the latter being probably involved in regulation of SC3 expression (PubMed:25015739).
What are the official names of this protein?
Short-chain dehydrogenase/reductase SAT2, Satratoxin biosynthesis SC1 cluster protein 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: DNCH_PROMS
Sequence: MKPADWLILQKKVRFGDCDSAGVIHFHNLLKWSHEAWEESIEIYGIPSQDIFPDFSIRKSQIIFPIVNCEANFLAPIKIGDLLKVKIVPHKINTHLFQVNSFFIKNGNKVAEGKIIHCSLDIDSRDKIELPDQLERWIEASNVSTNLKEC
What is the function of this protein?
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA hydrolase, DHNA-CoA hydrolase, DHNA-CoA thioesterase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
Protein: GCSP_BACFN
Sequence: MKTDLLACRHIGVNKADAEVMLRKIGVASLDELIDKTIPANIRLKAPLALPAPMTEYEFARHIAELAGKNKLFTTYIGMGWYNTITPAVIQRNVFENPVWYTSYTPYQTEVSQGRLEALMNFQTAVCDLTAMPLANCSLLDEATAAAEAVTMMYGLRSRNQQKAGANVVFIDENIFPQTLAVITTRAIPQGIEIRTGKFRDLEFTDDLFACVLQYPNANGNAEDYREFTEKAHTANCKVAVAADILSLALLTPPGEWGADIVFGTTQRLGTPMFYGGPSAGYFATRDEYKRNMPGRIIGWSKDKYGKLCYRMALQTREQHIKREKATSNICTAQALLATMAGFYTVYHGQEGIRNIASRIHSITVFLEKSIGKLGFKQVNKQYFDTLRFILPDSVSAQQIRTIALSKEVNLRYFDNGDVGLSIDETTDVAAANILLSIFAIAAGKDFQKVDDIPEATIISEELKRQTPYLTHEVFSKYHTETEMMRYIKRLDRKDISLAQSMISLGSCTMKLNAAAEMLPLSCAEFMCMHPLVPEDQAAGYRELIHNLSEELKVITGFAGVSLQPNSGAAGEYAGLRTIRAYLESIGQGHRNKVLIPASAHGTNPASAIQAGFTTVTCACDEHGNVDMDDLRAKAEENKDDLAALMITYPSTHGIFETEIVEICQIIHACGAQVYMDGANMNAQVGLTNPGFIGADVCHLNLHKTFASPHGGGGPGVGPICVAEHLVPFLPGHGLFGNSQNEVSAAPFGSAGILPITYGYIRMMGAEGLTMATKTAILNANYLAACLKDTYGIVYRGANGFVGHEMILECRKVYEETGISENDIAKRLMDYGYHAPTLSFPVHGTLMIEPTESESLSELDNFVLTMLTIWNEIQEVKNGEADKEDNVLINAPHPEYEVVSDQWEHCYTREKAAYPIESVRENKFWVNVARVDNTLGDRKLLPTCYGCFD
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: CYSG_SALDC
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLEAGARLTVNALTFIPQFTVWANEGMLTLVKGPFDETLLDSCWLAIAATDDDTVNQRVSDAAESRRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPQHLGQVARYAGQLRARVKKQFATMGERRRFWEKFFVNDRLAQSLANADEKAVNATTERLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADMPVALVENGTSVKQRVVHGVLTQLGELAQQVESPALIIVGRVVGLRDKLNWFSNY
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: PLSY_STAES
Sequence: MMIIVMLILSYLIGAFPSGLIIGKLFFKKDIRQYGSGNTGATNSFRVLGRPAGFIVTFLDIFKGFITVFFPLWFSVHADGVISTFFTNGLIVGLFAILGHVYPIYLKFNGGKAVATSAGVVLGVNPILLLILAIIFFSVLKIFKYVSLSSIIAAISCVIGSIIIHDYILLAVSGIVSIILIIRHKSNIVRIFKGEEPKIKWM
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VPU_HV1A2
Sequence: MQSLQILAIVSLVVVAIIAIVVWTIVLIEYRKILRQRKIDRLFDRIREKAEDSGNESERDQEELSALVEMGHLAPWDVDDL
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: PRMB_GORST
Sequence: MADTHKISFEPVDIEMEVGEDETILDAAFRQGIHLMHGCREGRCSCKSYMLEGDVQMDDYSTFACNDAEEAEGYVLLCRTYAYSDCEIELLNFDEDELLGGAPIQDVTTKVAAIEPMTPDIVSLKLDVVEPESVEFKSGQYFDLFIPGTEDKRSFSIATTPATPDRLEFLIKKYPGGLFAGMLTDGLSVGQEIKLNGPYGSCTLRNGHVLPIVAIGGGAGMAPLLSLLRHISETGLNRPVRFYYGARTAADLFLLDEIATLGEKIDDFSFTACLSESTDNAPEGVTVIGGNVTDIVNDNEADLARTEVYFCAPPPMVDAALALAEQHSVPHDQIFYDKFTSPAFDS
What is the function of this protein?
Reductase component of the propane 2-monooxygenase multicomponent enzyme system which is involved in the degradation of propane via the O2-dependent hydroxylation of propane (PubMed:14645271).  Reductase catalyzes the transfer of electrons from NADH or NADPH to monooxygenase (Probable).
What are the official names of this protein?
Propane 2-monooxygenase, reductase component, Prm.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family.
Protein: SYA_PASMU
Sequence: MKTTAEIRQSFLDFFHTKGHQIVASSALVPENDPTLLFTNAGMNQFKDVFLGMDKRPYSRATTAQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKKDAIHFGWEYLTSPRWLGLPAEKLWVTVYETDDEAYDIWNKEVGVPAERIIRIGDNKGAPYASDNFWAMGDTGPCGPCTEIFYDHGEHIWGGPPGSPEEDGDRYIEIWNIVFMQFNRHADGTMEPLPKPSVDTGMGLERISAVLQHVNSNYEIDIFQKLIAKVAELTGEKDLSNKSLRVIADHIRSCAYLIADGVIPSNEGRGYVLRRIIRRAVRHGNLLGAKEAFFYKLVPTLIDVMAEAGIGVKEKQATVEKLLRLEEEQFARTLERGLALLDEALANVKKGELSGEVAFKLYDTYGFPLDLTADVCRERNITIDEVGFDREMEAQRLRAQSASQFGMDYNNVIRVEGCTTFEGYTASESLAKVTALFADGKPVERIEAGQSAVVILENTPFYAESGGQIGDSGYLNGQGFSFEVKDTQKYGQVFGHIGELVSGSLTVGKSVNAVVDVKRRHNTSLNHSATHLLHAALRQVLGEHVVQKGSLVSDVALRFDFAHHEAITKAQLVEIECLVNQQIRANHLIQTELMELEAAKAKGAMALFGEKYADQVRVLTMGDFSIELCGGIHAKRTGDIGLCKITTETAIAAGIRRIEAITGENAMSWLHQQQALLAQSADLLKSDVNSIVEKIQQLQDKAKKAEKELQVLKEKSAMQAGSDLARSAVKINDVSVIVQKLDGVDTKSLRVVVDDLKNQLSSAVIVFASVVEEKVNLIVGVTSDLTSKVKAGELVNLLAQQVGGKGGGRPDMAMAGGTQIENVDHALSFATTWLKENL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.