PharMolix/UniProtQA huggingface dataset:
Protein: GCR_MOUSE
Sequence: MDSKESLAPPGRDEVPSSLLGRGRGSVMDLYKTLRGGATVKVSASSPSVAAASQADSKQQRILLDFSKGSASNAQQQQQQQQQQQQQQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPSSEQQNRKSQPGTNGGSVKLYTTDQSTFDILQDLEFSAGSPGKETNESPWRSDLLIDENLLSPLAGEDDPFLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSSTATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
What is the function of this protein?
Acts as a dominant negative inhibitor of isoform 1 (PubMed:20660300).  Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (By similarity).  Loses this transcription modulator function on its own (By similarity).  Has no hormone-binding activity (PubMed:20660300).  May play a role in controlling glucose metabolism by maintaining insulin sensitivity (PubMed:20660300).  Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (By similarity).  Directly regulates STAT1 expression in isoform Alpha-independent manner (By similarity).
What are the official names of this protein?
Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding (PubMed:11278753). The hormone-occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment (PubMed:10678832). In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (PubMed:27686098). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (PubMed:27686098). SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=After ligand activation, translocates from the cytoplasm to the nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Note=Expressed predominantly in the nucleus with some expression also detected in the cytoplasm.
Protein: PG130_VACCC
Sequence: MDFFNKFSQGLAESSTPKSSIYYSEEKDPDTKKDEAIEIGLKSQESYYQRQLREQLARDNMMAASRQPIQPLQPTIHITPQPVPTATPAPILLPSSTAPTPKPRQQTNTSSDMSNLFDWLSEDTDAPASSLLPALTPSNAVQDIISKFNKDQKTTTPPSTQPSQTLPTTTCTQQSDGNISCTTPTVTPPQPPIVATVCTPTPTGGTVCTTAQQNPNPGAASQQNLDDMALKDLMSSVEKDMHQLQAETNDLVTNVYDAREYTRRAIDQILQLVKGFERFQK
What is the function of this protein?
Component of the virion core.  Participates in virion assembly.
What are the official names of this protein?
39kDa core protein OPG130, p39, Protein A4.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG130 family.
Protein: UVRC_CALS4
Sequence: MDLQEKLKLLPEKPGVYLMKDEEGNIIYVGKASVLKNRVRQYFQNTDNHPPKVKVMLSHVEDFEYIVTDTELEALMLECNLIKKYKPKYNVLLKDDKNYPYIKITVAEDYPRIMFTRKIDMDGSKYFGPYGSAFAVRETIKLVRKMFPIRTCNVNIEKSLGKVRECLYYHIGLCSAPCTGRIEKEEYRKLVDQAVMFLEGKREWLVEKLKEEMQKAADELRFEEAARLRDQIFAIEKISEKQKVTSINEDEQDVISMARSDDIAHIEVFFVREGKLSGREHYYMKNTEGMGREEIISSFIKQFYESSPSVPKEIIIDVELEEKDLLEDWLSQKRGNRVSITVPLRGKKKELVDMVYQNAVEALKNEILAREKILKDPAVLELSNLLGIEYPKRIEAYDISNVRGEDNVGSMVVFVDGKPKKSEYRKFTIKYVEGQDDYQSMREMIERRFLHALEEKKQIEEGTLSKEKAKFIEMPDLILVDGGIGHVNAALEVIEKLGISVPVYGMVKDSRHRTRGLVGVSGEVQMPVTGRAFRLVAQIQEEAHRFAITFHRERQSKRFKTDLLNIKGIGEKRAKVLYEAFGSIEEIKKASLEELKKVKGMNERSAKAVYEYFHGEV
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRX1_HHV8P
Sequence: MKVQAENAARLGRQVLGLLPPPTHRVSLTRGPEFARGVRDLLSKYAASTRPTVGSLHEALRQAPFRQPTYGDFLVYSQTFSPQEPLGTFLFSFKQEDNGSSMDMLLTPTSLFMLSGMEAAKAPQTHKVAGVWYGSGSGLADFIPNLSELMDTGEFHTLLTPVGPMVQSVHSTFVTKVTSAMKGVGLARDEPRAHVGLTLPCDMLVDLDESCPMVQRREPAGLNVTIYASLVYLRVNQRPSMALTFFQSGKGFAEVVAMIKDHFTDVIRTKYIQLRHELYINRLVFGAVCTLGTVPFDSHPVHQSLNVKGTSLPVLVFANFEAACGPWTVFL
What is the function of this protein?
Structural component of the T=16 icosahedral capsid.  The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes.  These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2.  Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.
What are the official names of this protein?
Triplex capsid protein 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae TRX1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RN2A_ODOVE
Sequence: MFTLKKSFLLLFFLGTITLSLCEQERGADEDDGVEMTEEEVKRGLLDTIKNTAKNLAVGLLDKIKCKMTGC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Ranatuerin-2Va, ranat2Va, 2VEa.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Ranatuerin subfamily.
Protein: EXSC_PSEAE
Sequence: MDLTSKVNRLLAEFAGRIGLPSLSLDEEGMASLLFDEQVGVTLLLLAERERLLLEADVAGIDVLGEGIFRQLASFNRHWHRFDLHFGFDELTGKVQLYAQILAAQLTLECFEATLANLLDHAEFWQRLLPCDSDREAVAAVGMRV
What is the function of this protein?
Part of the regulatory cascade that plays a role in the transcriptional regulation of the type III secretion system (T3SS) (PubMed:16714561, PubMed:9045825).  Interacts with antiactivator ExsD to inhibit its activity leading to ExsA-mediated transcription (PubMed:15225323, PubMed:16980486).
What are the official names of this protein?
Transcriptional anti-antiactivator ExsC.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQZO_BACSU
Sequence: MGMKKKTNIKATGGLYIFGPSNRNEGKDLTPTIRLLEEKIKQMERMLSA
What are the official names of this protein?
Uncharacterized protein YqzO.
Protein: RF3_STAA9
Sequence: MNLKQEVESRKTFAIISHPDAGKTTLTEKLLYFSGAIREAGTVKGKKTGKFATSDWMKVEQERGISVTSSVMQFDYDDYKINILDTPGHEDFSEDTYRTLMAVDSAVMVIDCAKGIEPQTLKLFKVCKMRGIPIFTFINKLDRVGKEPFELLDEIEETLNIETYPMNWPIGMGQSFFGIIDRKSKTIEPFRDEENILHLNDDFELEEDHAITNDSAFEQAIEELMLVEEAGEAFDNDALLSGDLTPVFFGSALANFGVQNFLNAYVDFAPMPNARQTKEDVEVSPFDDSFSGFIFKIQANMDPKHRDRIAFMRVVSGAFERGMDVTLQRTNKKQKITRSTSFMADDKETVNHAVAGDIIGLYDTGNYQIGDTLVGGKQTYSFQDLPQFTPEIFMKVSAKNVMKQKHFHKGIEQLVQEGAIQYYKTLHTNQIILGAVGQLQFEVFEHRMKNEYNVDVVMEPVGRKIARWIENEDQITDKMNTSRSILVKDRYDDLVFLFENEFATRWFEEKFLEIKLYSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAJQ_SHIFL
Sequence: MPSFDIVSEVDLQEARNAVDNASREVESRFDFRNVEYSFELNDASKTIKVLSESDFQVNQLLDILRAKLLKRGIEGSSLDVPENIVHSGKTWFVEAKLKQGIESATQKKIVKMIKDSKLKVQAQIQGDEIRVTGKSRDDLQAVMAMVRGGDLGQPFQFKNFRD
What are the official names of this protein?
UPF0234 protein YajQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: RL15_VIBCH
Sequence: MLLNTLSPAAGSKHAPKRLGRGVGSGLGKTGGRGHKGQKSRSGGKVRPGFEGGQMPLKQRLPKFGFTSRKSFVSAEVRLSELAKVTGDVVDLNALKAANLVTKNIEFAKIVLSGEINKAVTVKGLRVTKGAKAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: MEND_ECO45
Sequence: MSVSAFNRRWAAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPTHSISLPRPTQDIPARWLVSTIDHALGTLHAGGVHINCPFAEPLYGEMDDTGISWQQRLGDWWQDDKPWLREAPRRESEKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLLQWQASCEPEEYWIVDDIEGRLDPAHHRGRRLIANIADWLELHPAEKRQPWCVEIPRLAEQAMQAVIARRDAFGEAQLAHRISDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASGKPTLAIVGDLSALYDLNALALLRQVSAPLVLIVVNNNGGQIFSLLPTPKSERERFYLMPQNVHFEHAAAMFELKYHRPQNWQELETTLVDAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: ISPD_DICT6
Sequence: MEKIVGIVVAAGKSKRFGEDKLLINIKGMPIVYYSIRKLHDIKDIEKIILVVRNEMLEYYKEKIKDWKLEKVYKLVLGGEERQDSVYNALKSVDFHCDYVLIHDAARPFVSIKKIEELIKFCTENSLSAILGIPVKDTIKVVDNTTKRIMETLDRSKLWIIQTPQMFPFEIIKEAHKKAREENFVGTDDASLVERLGIPVYVIEGEPFNIKITTKDDLLWMEGILSKSELV
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: MIAB_FRATN
Sequence: MKEQKKVFIKTLGCQMNEYDSARMHEVLNEHFDTVKTDDYKDADIILINTCSIREKAQEKVFHELGRWKGLKKTNEDLIIGVGGCVASQEGENIIKRAPFVDLVFGPQTIHRLPEMIKQKQKTQQSQVDISFPEVEKFDYLPEPKAEGAKAYVSIMEGCDKYCSYCVVPYTRGPEVNRPFEDVLAECAILAEQGVKEITLLGQNVNHYLGPMENGQTADLALLIHFIAEIDGIERIRFTTSHPVEFSQNLIDAYATVPELANHLHLPVQHGSDRILINMKRNHTILEFKQKIRKLRAIRPDITISSDFIVGFPGETEEDFQKLLDLVKEINFDQSFSFIYSKRPGTPAADLPDDTPMEVKKDRLKRLQDLLNSNAQIISRQMVGTNQRILVDGTSKKDDNILSGRTENNRVVNFKGDKSLIGQFAMVKITESLPNSLRGELI
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIGA_PSEAE
Sequence: MDTLAPESTRQNLRSQRLNLLTNEPHQRLESLVKSKEPFASRDNFARFVAAQYLFQHDLEPLYRNEALARLFPGLASRARDDAARADLADLGHPVPEGDQSVREADLSLAEALGWLFVSEGSKLGAAFLFKKAAALELDENFGARHLAEPEGGRAQGWKSFVAILDGIELNEEEERLAAKGASDAFNRFGDLLERTFA
What is the function of this protein?
Involved in heme degradation.  Catalyzes the degradation of heme to biliverdin, with the release of iron.  Forms biliverdin delta (70%) and beta (30%).
What are the official names of this protein?
Heme oxygenase PigA.
What is the protein family that this protein belongs to?
Belongs to the heme oxygenase family.
Protein: RSMG_PSEP1
Sequence: MSSLVTPQHAEELSTGARQLGVELTAEQHEKLLGYLALLIKWNKAYNLTAVRDPDEMVSRHLLDSLSVMSFIHNDRDNWLDVGSGGGMPGIPLAILHPHKRVTVLDANGKKTRFLTQVKMELKLDNLTVIHSRVEAFQPAQPFDGIISRAFSSMENFTNWTRHLGDTGTQWLAMKGLHPADELVALPADFTVESEQALTVPGCQGQRHLLILRRKA
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_BACAC
Sequence: MTVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRNISILPFDKSNVKEGQVIIAGNAFPDTHEEIVAAKELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLAHVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLSYNPDYAIMTNIDFDHPDYFTDINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDGTIFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFNEKPMGEQVIIDDYAHHPTEINATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLSKADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTTTDVLKKHKNGVLIFMGAGDIQKFEAAYVKEVQVAEK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_PROMP
Sequence: MSQIESLSQIEGKLNNLSLLANENIKNAKSDSELDQLRVSLLGKKGELSIILKTMGKLSSVDRPIIGQKANLIKINLQDLITERKNQLISEAIDKQIEDEKIDVTIPSTGTLPGNKHPLISTQDEIIDIFCGLGYSVENGPEIESDFYNFESLNIPKNHPARDMQDTFYLDENRLLRTHTSPVQIRYLENNPPPVRIIAPGRVYRRDAVDATHSPVFNQVEVLCIDQDINFSHLRGTVLTFLKTFFGDIPVRFRASYFPFTEPSAEVDVQWKGKWLEVMGCGMVDPKVLEKLGIDSEKWTGFAAGLGVERFCMVRHQIDDIRRFYTNDLRFLKQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNM_BACSU
Sequence: MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRITVFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIAEAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSILGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY
What is the function of this protein?
Part of the ABC transporter complex GlnHMPQ involved in glutamine transport.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Probable glutamine ABC transporter permease protein GlnM.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1331_THEVO
Sequence: MFDGSDLKNLFSLDGFLKTIQFEPEYIREGEISIIVPLRNNLLRIGEIMNGGAVMAISDAIGGLSAMTYPGIVNQVTVSFNTEFMRPIAKGPVRFISRVDRIGKSIAYVEVLVYDGENLLSSKSTGVYFLYRS
What are the official names of this protein?
Putative esterase TV1331.
What is the protein family that this protein belongs to?
Belongs to the thioesterase PaaI family.
Protein: PRMA_BRADU
Sequence: MQPSPTHRASFSIGSEAAARRVVDVLTEVFFEGDAAVAAFERPDGQWDVTLHFADAPDQAWLRELVVNSAGNEIADTLAFDTVEAKDWVKASLEDLVPVPAGRFVVHGSHDRDRVAPNKLKIEIEAALAFGTGHHGTTRGCLLLLDHVLKSSRPSNVLDLGTGTGVLAIAAAKALHRAVLASDIDPPSVRVAAENGRLNEVGHHVRVIRATGFAAPDFARAGPFDLVLANILANPLRHLASPMARHLAPGARVILSGLLTHQAPAVIAAYRARGLVPLRHLRIEGWSSLLLRKVG
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGO_CERS5
Sequence: MAPVQAADEMYDSNPHPDRRQLVSNGFEVNLPDQVEVIVRDLPDPSKVKEERTRLMGYWFVHWFDGKLFHLRIKAGGPNVDGEHRAIRTAEHPWLLRARLDDALEEALPKYAAVKKRPFTFLAQKDELIDAAATAAGLSHRLLNSFKVIPRFALSPKIYEPVDGTTRVGVFVTIGMRYDIEASLRDLLEAGIDLRGMYVVRRKRQPGERGLLGRVRAISDDMVQLFEETDLASVNVNDAKLEGSKENFTRCLSALLGHNYKKLLNALDDQEAGYRTGPRFDDAVRRMGEFLAKKPIRLADNINAQVGDRIVFSNEGQARNVRLAPKVEYVFDRTGAKSAEYAWRGLSQFGPFDRPSFANRSPRILVVYPSSTQGKVENFLSAFRDGMGSNYSGFSKGFVDLMGLTKVEFVMCPVEVSSADRNGAHTKYNSAIEDKLAGAGEVHAGIVVLFEDHARLPDDRNPYIHTKSLLLTLGVPTQQVRMPTVLLEPKSLQYTLQNFSIATYAKLNGTPWTVNHDKAINDELVVGMGLAELSGSRTEKRQRFVGITTVFAGDGSYLLGNVSKECEYEGYSDAIRESMTGILRELKKRNNWRPGDTVRVVFHAHRPLKRVDVASIVFECTREIGSDQNIQMAFVTVSHDHPFVLIDRSERGLEAYKGSTARKGVFAPPRGAISRVGRLTRLLAVNSPQLIKRANTPLPTPLLVSLHPDSTFKDVDYLAEQALKFTSLSWRSTLPAATPVTIFYSERIAELLGRLKSIPNWSSANLNIKLKWSRWFL
What is the function of this protein?
A catalytically inactive argonaute protein.  Binds 5'-phosphorylated RNA as the guide (gRNA) and short DNA as target DNA (tDNA); does not bind other nucleic acid combinations, does not bind tDNA alone (PubMed:27325485, PubMed:29996105, PubMed:33333714).  Has highest affinity for gRNA that begins with 5'-phospho-U and poor affinity for gRNA with 5'-OH (PubMed:27325485, PubMed:29996105).  Upon expression in E. coli, plasmid sequences are found in RsAgo, its induction leads to plasmid degradation and suppression of genes encoded on foreign plasmids, suggesting it may also interfere with transcription (PubMed:24034694, PubMed:27325485).  Does not interact with preformed gRNA:tDNA duplexes.  Mismatches and nt bulges are tolerated in the ternary complex, however, they significantly reduce the affinity of RsAgo:gRNA for tDNA.  Mismatched tDNA can cause dissociation of gRNA from RsAgo (PubMed:29996105).  In situ binds 2 populations of RNA (15-19 and 45 nucleotides, nt) and a population of ssDNA 22-24 nt in length.  The small sense RNA is probably derived from mRNA degradation and strongly enriched for U in the first and U/C in the second positions.  The small DNA is enriched for sequences complementary to the RNA, with 3 nt overhangs on both ends; another nuclease may trim the ends.  The sequences are largely derived from exogenous plasmids or genome-encoded foreign elements such as prophages and transposons (PubMed:24034694).  Forms a ternary complex with gRNA and double-stranded tDNA only when the tDNA is open (PubMed:33333714).
What are the official names of this protein?
Protein argonaute, RsAgo.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Long pAgo subfamily.
Protein: MNHE1_STAA8
Sequence: MAVQLVLNFIIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVITLYRIIKLVIIFLIELIKANFDVLKIIIKPSIKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREVGEI
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit E1, Mnh complex subunit E1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: E13E_TOBAC
Sequence: MSTSHKHNTPQMAAITLLGLLLVASSIDIAGAQSIGVCYGMLGNNLPNHWEVIQLYKSRNIGRLRLYDPNHGALQALKGSNIEVMLGLPNSDVKHIASGMEHARWWVQKNVKDFWPDVKIKYIAVGNEISPVTGTSYLTSFLTPAMVNIYKAIGEAGLGNNIKVSTSVDMTLIGNSYPPSQGSFRNDARWFVDAIVGFLRDTRAPLLVNIYPYFSYSGNPGQISLPYSLFTAPNVVVQDGSRQYRNLFDAMLDSVYAALERSGGASVGIVVSESGWPSAGAFGATYDNAATYLRNLIQHAKEGSPRKPGPIETYIFAMFDENNKNPELEKHFGLFSPNKQPKYNINFGVSGGVWDSSVETNATASLVSEM
What is the function of this protein?
Implicated in the defense of plants against pathogens.
What are the official names of this protein?
Glucan endo-1,3-beta-glucosidase, basic vacuolar isoform GGIB50, (1->3)-beta-glucan endohydrolase, (1->3)-beta-glucanase, Beta-1,3-endoglucanase, basic, Glucanase GLA.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: UFOG_VITVI
Sequence: MSQTTTNPHVAVLAFPFSTHAAPLLAVVRRLAAAAPHAVFSFFSTSQSNASIFHDSMHTMQCNIKSYDISDGVPEGYVFAGRPQEDIELFTRAAPESFRQGMVMAVAETGRPVSCLVADAFIWFAADMAAEMGLAWLPFWTAGPNSLSTHVYIDEIREKIGVSGIQGREDELLNFIPGMSKVRFRDLQEGIVFGNLNSLFSRMLHRMGQVLPKATAVFINSFEELDDSLTNDLKSKLKTYLNIGPFNLITPPPVVPNTTGCLQWLKERKPTSVVYISFGTVTTPPPAEVVALSEALEASRVPFIWSLRDKARVHLPEGFLEKTRGYGMVVPWAPQAEVLAHEAVGAFVTHCGWNSLWESVAGGVPLICRPFFGDQRLNGRMVEDVLEIGVRIEGGVFTKSGLMSCFDQILSQEKGKKLRENLRALRETADRAVGPKGSSTENFITLVDLVSKPKDV
What is the function of this protein?
In the presence of other necessary color factors, this glycosylation reaction allows the accumulation of anthocyanin pigments (Probable).  Involved in the formation of red wine pigments (Probable).  UDP-glucose (UDP-Glc) is the physiological sugar donor, and cyanidin is the natural acceptor in vivo (PubMed:9535914).  Can glucosylate the anthocyanidins delphinidin, peonidin, pelargonidin and malvidin (PubMed:9535914).  The flavonols quercitin and kaempferol can also be glucosylated in vitro, but with glucosylation rates 50-100 times lower than cyanidin (PubMed:9535914).  In vitro, can use UDP-Glc, UDP-5SGlc, UDP-Xyl, UDP-Man, UDP-Gal, UDP-GlcNAc, GDP-Glc, dTDP-Glc and dTDP-Xyl as sugar donors, but not UDP-6OMeGal, UDP-Ara, UDP-6FGal, UDP-GlcN, UDP-2FGal, UDP-5SAra, GDP-Man, GDP-Fuc, UDP-Fuc or UDP-Rha (PubMed:16482224).
What are the official names of this protein?
Anthocyanidin 3-O-glucosyltransferase UFGT, Flavonol 3-O-glucosyltransferase, UDP-glucose flavonoid 3-O-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: RS21_XANAC
Sequence: MPSVKVRENEPFEFALRRFKRTCEKAGVLAETRKREFYEKPTQERKRKAAAAVKRQLRRSSRDVTKRQRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: SAPC_ECOL6
Sequence: MPYDSVYSEKRPPGTLRTAWRKFYSDASAMVGLYGCAGLAVLCIFGGWFAPYGIDQQFLGYQLLPPSWSRYGEVSFFLGTDDLGRDVLSRLLSGAAPTVGGAFVVTLAATICGLVLGTFAGATHGLRSAVLNHILDTLLAIPSLLLAIIVVAFAGPSLSHAMFAVWLALLPRMVRSIYSMVHDELEKEYVIAARLDGASTLNILWFAVMPNITAGLVTEITRALSMAILDIAALGFLDLGAQLPSPEWGAMLGDALELIYVAPWTVMLPGAAIMISVLLVNLLGDGVRRAIIAGVE
What is the function of this protein?
Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.
What are the official names of this protein?
Peptide transport system permease protein SapC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YFBV_ECO27
Sequence: MSTPDNRSVNFFSLFRRGQHYSKTWPLEKRLAPVFVENRVIKMTRYAIRFMPPIAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPAILNWFYEVRGKLQESGQVLAPVEGKPDYQALADTLKRAFKQLDKTFLDDL
What are the official names of this protein?
UPF0208 membrane protein YfbV.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.