PharMolix/UniProtQA huggingface dataset:
Protein: SSRP_SALEP
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANIGDSYVILKDGEAWLFGANFTPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRINREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDLKEREWQLDKARIMKNAGR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ALEX_HUMAN
Sequence: MMARPVDPQRSPDPTFRSSTRHSGKLEPMEATAHLLRKQCPSRLNSPAWEASGLHWSSLDSPVGSMQALRPSAQHSWSPEPSVVPDQAWEDTALHQKKLCPLSLTSLPREAAVNFSYRSQTLLQEAQVLQGSPELLPRSPKPSGLQRLAPEEATALPLRRLCHLSLMEKDLGTTAHPRGFPELSHKSTAAASSRQSRPRVRSASLPPRTRLPSGSQAPSAAHPKRLSDLLLTSRAAAPGWRSPDPRSRLAAPPLGSTTLPSTWTAPQSRLTARPSRSPEPQIRESEQRDPQLRRKQQRWKEPLMPRREEKYPLRGTDPLPPGQPQRIPLPGQPLQPQPILTPGQPQKIPTPGQHQPILTPGHSQPIPTPGQPLPPQPIPTPGRPLTPQPIPTPGRPLTPQPIQMPGRPLRLPPPLRLLRPGQPMSPQLRQTQGLPLPQPLLPPGQPKSAGRPLQPLPPGPDARSISDPPAPRSRLPIRLLRGLLARLPGGASPRAAAAAACTTMKGWPAATMTPAETSPTMGPPDASAGFSIGEIAAAESPSATYSATFSCKPSGAASVDLRVPSPKPRALSRSRRYPWRRSADRCAKKPWRSGPRSAQRRNAVSSSTNNSRTKRWATCVRTACCF
What is the function of this protein?
May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.
What are the official names of this protein?
Protein ALEX, Alternative gene product encoded by XL-exon.
What is the protein family that this protein belongs to?
Belongs to the ALEX family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cell projection, ruffle. Note=Predominantly associated with cell membrane ruffles.
Protein: TVA39_HUMAN
Sequence: MKKLLAMILWLQLDRLSGELKVEQNPLFLSMQEGKNYTIYCNYSTTSDRLYWYRQDPGKSLESLFVLLSNGAVKQEGRLMASLDTKARLSTLHITAAVHDLSATYFCAVD
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 39.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RL32_ECO45
Sequence: MAVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRHHITADGYYRGRKVIAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: KITH_BACC0
Sequence: MYLINQNGWIEVICGSMFSGKSEELIRRVRRTQFAKQHAIVFKPCIDNRYSEEDVVSHNGLKVKAVPVSASKDIFEHITEEMDVIAIDEVQFFDGDIVEVVQVLANRGYRVIVAGLDQDFRGLPFGQVPQLMAIAEHVTKLQAVCSACGSPASRTQRLIDGEPAAFDDPIILVGASESYEPRCRHCHAVPTKQR
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORC2_BOVIN
Sequence: MTSTLELKADKMLKVQFVGDDDVLNHILDREGGPKIKKERAQLLVNTQKIIKKPENELEEDDQEVLKDHNYVEVLGQDVQESLKNGSATDGGNKVYPFQNRKHPEKMAKLASELAKTPRKSVLLNMKNDPKITIDIPQCSKGHSSSDKSQLKNNDKSEFLSTAPRGLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEYEEDTNEDILSQKIQAQNREVSAPVFRETPSKKMKREKTSHLVEKYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLHNLLSKVSPSFSAELKQLNQQHEQLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDCIHIVINGFFPGISVKSVLNSVTEVLDHVGTFRSVLDQLEWITNKFKEDSSLELFLLIHNLDSQMLRGDKSQQIIGQLSSLRNIYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSHYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLIKYQLDNQDNPSYIGLCFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGILTDFLENEEEEL
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent.  The specific DNA sequences that define origins of replication have not been identified yet.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.  Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3.  Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation.  Also stabilizes ORC3 (By similarity).
What are the official names of this protein?
Origin recognition complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the ORC2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RF3_COLP3
Sequence: MSVQQQQVDLRRTFAIISHPDAGKTTITEKVLLFGQALQRAGTVKGKKSGQHAKSDWMEMEKERGISITTSVMQFPYNDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDVAKGVEARTVKLMEVTRLRDTPIITFMNKMDRDVRDPMEVMDEVEEVLKIKCAAITWPIGMGKEFKGIYHILDDEITLYQSGLGHMIQEKRVIKGLNNPELDKIIGNYADDLREELELVSGASHDFNLEEFLKGELTPVFFGTALGNFGVDHMLDGLTKWAPKPLPRKTDLREVTAEEEKFSGFVFKIQANMDPKHRDRIAFMRICSGKYEKGMKMKQVRLAKDVKIADAVTFMAGDRSNVEEAFAGDIIGLHNHGSIQIGDTFTAGEMMKFSGIPNFAPEMFRRIRLRDPLKAKQLQKGLIQLSEEGAVQVFRPFINNDMIVGAVGVLQFEVVVQRLKTEYKVDAIYEAISVATARWCTCDDERTLEQFKKKSGDYLALDGGNNLTYIAPTMVNLSLAQERNPDIVFHSTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAX15_MESMA
Sequence: MKISFLLLALVICSIGWSEAQFTDVKCTGSKQCWPVCKQMFGKPNGKCMNGKCRCYS
What is the function of this protein?
Potent blocker of both large-conductance calcium-activated potassium channels (KCa1. 1/KCNMA1) and voltage-gated potassium channels (Kv1. 3/KCNA3) (PubMed:9354615, PubMed:29483648).  Has also been shown to moderately inhibit Kv1. 2/KCNA2 and weakly inhibit Kv1. 1/KCNA1 channels, as well as 5-hydroxytryptamine 3 receptors (HTR3A) (PubMed:29483648).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 1.5, BmTX1, Neurotoxin TX1.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MPH1_DEBHA
Sequence: MNSDDDSVFNDDLNDSEITNLIHNIPSSSSSCSSSKNKLQRNLYGEIIPEQYVEIDSSKGYTELPPTHHALNYENLSSYIYPTNFEVRDYQFNIVQRAFYDNLLVALPTGLGKTFIASTVMLNFTRWFPRGKIIFMAPTKPLVAQQIKACCGITGIPTSEVAILLDKSRRNRADIWDSKTVFFTTPQVVENDLTAGIIDPKEVVLLVIDEAHKSKGNYAYNNVVKFITRFNISFRILALTATPASDVEGVQEIIDNLSISKVEVRTEQSIDITKYMKQKKIERVTVSPSVEICELVDMLCTAIQPVLSMANERRIYDMSDPSKINAFQVIDASQRLLKNPTIPEGLKWQNYFILQILNVVGQALRRLNIYGIKSFYNYFDQKHKEFTIKFKNKKSNNQTAARFYFHDNIKLILDKCKELIADDNFLGHPKLEILINELDEFFKENEANDSRVIIFTEFRESALDIVSSIERIGSNLRPHIFIGQSKEKEKFDEEAYLSKGKKGRTKGKATKGKQNSETPERSTSRTSSEDAQIKGMNQKLQKDLIKKFKKGEYNILVATSIGEEGLDIGEVDLIVCYDSTSSPIKNIQRMGRTGRKRDGKVLLLFAGNEESKFDKAMAGYEFIQQHIMNGRLITLAQSNRIIPKSYKPIVEKKFIEIPEENTEIKAEEDEDEIIRIATSYMNNKGKKVTKSKSKSKSNSKSKKIEKRFFMPDNVTTGFQNVTSMVRKADSDKSVADKRREKDLLDKLLDSDTEDELLIQSKKSPVKENQSKRPNSEHICEEDSRQETENNSNESNGSFENENDQNKESGVSYPLSYRQTPPKLGIRRLSPQVSMNINLDAPVATEEAAPLVTGKSTSPPENVAEKRNSPILNSSNRECAPKQKTLGLKRRKANSITDQLKRHYSRVIKPNTAYRTITVSDDEKSVEDSINNQQLHKNKNLGSTSDDDDAFDEGDVFDDGMDDELALIANDKLSSFERSLSPNLPAQNNASDEVYKHEFSPGEGVLNQEQMLELYTSYFSLLDPADRVDFYDPLNFNQKPNTSINHRGRIGHSQVSRRLLQSSKFIGSVSTTTAKNIVKRYAQTYNTTNHQHNMHIVQEITNSSSK
What is the function of this protein?
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance.  Capable of unwinding D-loops.  Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair.  Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
What are the official names of this protein?
ATP-dependent DNA helicase MPH1, FANCM-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: UXUA_ECOSM
Sequence: MEQTWRWYGPNDPVSLADVRQAGATGVVTALHHIPNGEVWSVEEILKRKAIVEDAGLVWSVVESVPIHEDIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRPGAEADYTEEEIAQAAERFATMSDEDKARLTRNIIAGLPGAEEGYTLDQFRKHLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVDTVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTMREDNPKTFHEAAHLNGDVDMYEVVKAIVEEEHRRKAEGKEDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIQRAFFSR
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: RHL_MACFA
Sequence: MSSKYPRSVRCCLPLWALTLEAALILLFFFFTYYDASLEDQKGLVASYQVCQDLTVMAVLGLGFFTSNLRRNSWSSVAFNLFLLALGVQWAILLDGFLSQFSPGKVVIKLFSIRLATRSTTSMLISMNAVLGKVNLAQLVVMELVELTVFGTMRIVIYNIFKIDYGMNMMHIHVFAAYFGLTVAWCLPKPLPKGTEDKYQTTTSPSLFAMLGTLFLWMFWPTFNSALLLNPIERKNAVFSTYYALAVSAVTAISVSSLAHPQRKINMTYMPNAGLAGGVAVGASCHVIHSPWIAMVLGLVAGLISFGGAKCLPVCFNRVLGIHESHSMHYTFGLPALLGEITYIVLMALRVFWASSNMIGFQVLLSTGTLSLAMAMSITSGLLTGLLLNLKIWKGPHVAKYFDDQAFWEFPHLAVGF
What is the function of this protein?
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
What are the official names of this protein?
RH-like protein, Rhesus-like protein.
What is the protein family that this protein belongs to?
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PURA_BAUCH
Sequence: MSNNVVVLGTQWGDEGKGKVVDILTERAKYVIRYQGGHNAGHTLVINGEKTILHLIPSGILRENVKSIIAHGVVLSPEALIKEIHELEARGIPVRQRMLISEACPLLLSYHVAMDIAREKARGTNALGTTGRGIGPAYEDKVARRALRVSDLFNKESFAIKLKDIVDYYNFQLVHYYKVEAVSYQKILNDIMVVTDMLTSMVADISVLLYNAYQQGDIMMFEGAQGTLLDIDHGTYPYVTSSNTTAGCVTTGSGLGPHYIGYVLGIVKAYSTRVGAGPFPTELFDDTGNFLCLKGHEFGATTGRRRRTGWLDAVALRRAVHINSISGLCLTKLDVLDGLKEIKICSAYRMQDGCIIYTTPIALEKWEGIEPIYETLPGWNETTVGIQALADLPRAAHQYIKLIEELTRVPVDIISTGPDRRDTIILHDPFSD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPD1A_XENLA
Sequence: MRHMQSVTRATSICGSGVKQVIGKGHPHARVVGARKARIPEREELSVKPKMVRNTHLNLQPQERQAFYRLLENEQIQEFLSMDSCLRISDKYLIAMVLAYFKRAGLYTSEYTTMNFFVALYLANDMEEDEEDYKYEIFPWALGDSWRELFPQFLRLRDDFWAKMNYRAVVSRRCCDEVMSKDPTHWAWLRDRPIHHSGAMRGYLRNEDDFSPRGPGLTPASCTLCHKAGVCDSGGVSHNNSSSPEQEIFHYTNREWSQELLMLSPELLLDPECTHDLHILQEPLVGLEPDGTALEWHHL
What is the function of this protein?
Stimulates oocyte maturation by promoting meiotic G2/M progression in resting oocytes, via activation of the MAPK cascade and cdc2-cyclin B.  Also activates the kinase activity of cdk2; this activation does not appear necessary for oocyte maturation.  Necessary for polyadenylation in oocytes.
What are the official names of this protein?
Speedy protein 1-A, Spy1-A, Protein Ls26, Rapid inducer of G2/M progression in oocytes A, RINGO-A, XSpy1-A, p33 ringo-A, xRINGO-A.
What is the protein family that this protein belongs to?
Belongs to the Speedy/Ringo family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTS1_SALIN
Sequence: MIMNDIITVTEAAQLLELTPQRVRTMCKQGSIDAYQSGRTWLIKSSSVEKLMLVNSLSDAQNSYSMLASEPKNKPKALSFFSGAMGLDLGIEQAGFETLLASEIDKAARDTILSNRPNMALIGDIRDYTTEDILKLAGVSSGNEIDLIMGGPPCQAFSTAGKRLGLEDERGNVFIKYLDVALDIRPKYIVIENVRGLLSAPMKHRPHNERGEGLPPLKSEEQPGGVLHYIIRIIKSAGYSVSFNLYNSANFGVPQIRERVIIICSRDGSRVPFLQPTHSEKGEYGLPKWITLRETITNLKNITHEHVLFPEKRLKYYRLLKEGQYWKHLPEDLQKEALGKSFFLGGGKTGFLRRVAWDRPSPTLVTHPAMPATDLAHPDELRPLSVQEYKVIQQFPEEWVIKGKLLDKYRQLGNAVPIGLGLAVGKNILDHMNGRKIESFPNFRYSRYKNTSDLDIFGELV
What is the function of this protein?
A methylase that recognizes the double-stranded sequence 5'-GGWCC-3', methylates C-4 on both strands, and protects the DNA from cleavage by the SinI endonuclease.
What are the official names of this protein?
Type II methyltransferase M.SinI, M.SinI, Cytosine-specific methyltransferase SinI, Modification methylase SinI.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Protein: YR802_MIMIV
Sequence: MEIPYITPAKLLSTNVLPLNGVKTAFVCFCPMPSVFSKYRLNVEVNTRLFLHVHNMHIMFGQYGATKFIVITEVYGGPVGVTIVEELKHYGIDKIIGIGFVGSFDPAIKTGSIVDAEKSLIEHGTTPHYLSADTKYTFPTLKIELPQLNVNKVCIWTTNALYREFKSDIIEAKNKQCSVVNMDTSHLYAACELLNVSCRYFAVVSDMLDLDGAENWSNDLTDAINHNDSDISVSMSSLIDHIIRQLN
What are the official names of this protein?
Uncharacterized protein R802.
Protein: Y120_HAEIN
Sequence: MADPHIKSPMDFLDYLTVIIYRTGFVIAALAVLTVSWYPDLSLTFILIAATCCASSLHIYLKSFRLLFQFATWIGLLFYINHYPALALGGALLTLGGLCFKEYFCFRVPLLNLQPIFVACLWFSWVLNNLIALRIFSIISGVLLLVLAIQKWRMPLHFDIGDKTKYQI
What are the official names of this protein?
Uncharacterized protein HI_0120.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FMT_LACLS
Sequence: MTKTKIIFMGTPQFAATVLKGLIDSNQYEILAVVTQPDRKVGRKQELRMTPVKELALTVNLPVLQPEKLSGSVEMTQIMTLLESGEVGIVTAAFGQFLPGKLLDVARFAVNTHASLLPKYRGGAPIHYAIMNGEKEAGVTIMEMIRKMDAGDMIAQNSTPILEEDNVGTMFEKLAFVGRDLLLETLPKYLEGQLKAQAQNEDEVTFSPNISPEEEKIDWNKSAREIFNKVRGMNPFPVAHTLWNGERFKIYESKVADEIVNNSDNPLQAGQIVEKTKKSLKVATGNGILELLTVQPAGKPKMDIVSFLNGLGQKMQVGDKLGD
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: UCP2_PIG
Sequence: MVGFKATEVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGERRGPVQAAASAQYRGVLGTILTMVRNEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKHFYTKGSEHAGIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYRSTVDAYKTIAREEGLRGLWKGTSPNVARNAIVNCAELVTYDLIKDTLLKADLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAPGQYSSAGHCALTMLQKEGPRAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALMAARASREAPF
What is the function of this protein?
Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance.  Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity).  Proton transporter activity is debated, but if it occurs it may mediate inducible proton re-entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress.  Proton re-entry may be coupled to metabolite transport to allow for proton flux switching and optimal ATP turnover (By similarity).  Regulates the use of glucose as a source of energy.  Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH).  This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis.  Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation.  Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity).  Can unidirectionally transport anions including L-malate, L-aspartate and phosphate (By similarity).  Does not mediate adaptive thermogenesis (By similarity).
What are the official names of this protein?
Dicarboxylate carrier SLC25A8, Mitochondrial uncoupling protein 2, UCP 2, Solute carrier family 25 member 8.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NADK_TREDE
Sequence: MKKVLIVLSIEKPNAKKICKEIEAFLSAKGIDSFVYKYDGISHSPELNEDYDLAISLGGDGTVLFTARYSAPRHIPVFPINLGRFGFIANIEPKEWEGELLHLLNGKQALHKRMLLSASINRKNKEIVKYEALNDAVVSGSGIAKLINLDISFNGISFGVFRADGVIVSTPTGSTAYSAASGGPILDPDVSAFVLTPISPFSLSNRPLVLPSSGQMKIKILPARAKDIIVSIDGQEMVSLQEDDEIIISESPNKVKMAGCSPDNFYKALRSKLGWSGSSSPKLN
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CINA_BACLD
Sequence: MKLERKAEIIAVGSELLLGQIVNTNAQFISRHLAEIGINVFYHTAVGDNPERLKQVIQTAQQRSDFIIFSGGLGPTKDDLTKETIAEVVGRPLKLDDEAFESIQDYFKKTNREMSPNNRKQALILEGSDVLPNRFGMAPGMLLEHESRFYMLLPGPPKELEPMFENEAKPLILEKLGSREKIVSRVLRFFGIGESQLETDLEDLIDAQTNPTIAPLAADGEVTLRLTAKHADPEETNRLLKETEDRILERVGEFFYGYDDTSLAEELAKACRSKGMTLAAAESFTGGLFSSWLTEMSGASEYFKGGAVCYTNELKVSAAGVSEDTLQRYGAVSAQCAKELAAGIRVKTGSDIGISFTGVAGPNTQEGHPAGKVFIGISVKDQAEEAFEFQFAGSRSAVRKRSAKYGCHLLLKMMEK
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: CHMP5_XENLA
Sequence: MNRIFGKSKPKVPPPTLTDCITNVDGRAESIEKKISRLDAELIKYKDQMKKMREGPSKNMVKQKALRVLKQKRMYEQQRDNLNQQSFNMEQANYTIQTLKDTKTTVDAMKVGAKEMKKAYKQVKIDQIEDLQDQLEDMMENANEIQEALSRSYGTPEIDEDDLEAELDALGDELLLDDDTSYLDEAASAPAIPEGVPNDSKNKDGVLVDEFGLPQIPAT
What is the function of this protein?
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 5, Chromatin-modifying protein 5.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein.
Protein: BFRB_NEIMB
Sequence: MKGDRLVIRELNKNLGLLLVTINQYFLHARILKNWGFEELGEHFFKQSIVEMKAADDLIERILFLEGLPNLQELGKLLIGESTEEIIACDLTKEQEKHEALLAAIATAEAQQDYVSRDLLEKQKDTNEEHIDWLETQQELIGKIGLPNYLQTAAQED
What is the function of this protein?
Iron-storage protein.
What are the official names of this protein?
Putative bacterioferritin B, BFR B.
What is the protein family that this protein belongs to?
Belongs to the bacterioferritin family.
Protein: SIRC_SALTS
Sequence: MVLPSMNKSVEAISNNHLQQPNKFPLINGLADVRDYYVANCLLFKLNKGSLRIENEFGEFIERSAPCLFLLEKDQTITLSMSEIEGHIDFSSLEVSYDLMQKFYKVFYSTRNYNDRELSLKTKPKYFFHADLLPGMSDTFDSILHGVACPRVCSNVSIDDHDYSYFSLMYLISAFVRKPGGFDFLERAIKITTKEKVYNIIISDLTRKWSQAEVAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYFIAIFKRHFKITPLSFMRTMNH
What is the function of this protein?
Positive regulator of the expression of the invasion-associated type III secretion system encoded within SPI-1 (pathogenicity island 1).
What are the official names of this protein?
Transcriptional regulator SirC.
Protein: CODY_BACC0
Sequence: MELLAKTRKLNALLQSAAGKPVNFREMSDTMCEVIEANVFVVSRRGKLLGYAIHQQIENERMKQMLAERQFPEEYTQSLFNITETSSNLDVNSAYTAFPVENKELFGQGLTTIVPIVGGGERLGTLVLARLGQEFLDDDLILAEYSSTVVGMEILREKAEEIEEEARSKAVVQMAISSLSYSELEAIEHIFEELNGTEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKGTYIKVLNDKFLHELAKLKTN
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.