PharMolix/UniProtQA huggingface dataset:
Protein: NADK_CAMLR
Sequence: MKKCINIEKIQKIGLFCRLNTNLNKQIDFLRAIFLQKNIELVLLEQEKINLKDLQELDFLISLGGDGTLLSLCRQAYQAKKPILGINAGNLGFLTALSFNEAESFFKDFFKNDFKIEKAKMLQITLYKKNKIIKKFAFNDAVFSRDNALMANVEVFFENKLFNAYYGDGLIIASSSGSTAYNISAGGPIVHPWSEIFVLTPVCSHSLTQRPIVLPYGFELELKVEHCLLYLDGQEVVDPKEYDKILIGLSKKELSFIHKKNRDYFQVLKEKLNWGK
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAII_ECO45
Sequence: MTIWVDADACPNVIKEILYRAAERMQMPLVLVANQSLRVPPSRFIRTLRVAAGFDVADNEIVRQCEAGDLVITADIPLAAEAIEKGAAALNPRGERYTPATIRERLTMRDFMDTLRASGIQTGGPDSLSQRDRQAFAAELEKWWLEVQRSRG
What are the official names of this protein?
UPF0178 protein YaiI.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: KCD15_XENLA
Sequence: MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHLDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKEINLLYEEAKYYQLLPMVKELERWKQDKEHRKHFQPCDCLVVRVTPDLGERIALSGEKALIEEIFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVLERLFQKGFHVAASCGGGVDSSQFSEYVLCREDRRMQPNTMRIKQEPLD
What is the function of this protein?
During embryonic development, interferes with neural crest formation.  Inhibits AP2 transcriptional activity by interaction with its activation domain.
What are the official names of this protein?
BTB/POZ domain-containing protein kctd15, Potassium channel tetramerization domain-containing protein 15.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS14_FRATT
Sequence: MAKKSMIQRELKREKLVAKYAQKRAEFKAIILDINSTEEQIWEAQIKLQKLPVNSSASRVQRRCKVTGRPHAVYRKFGLCRNKLREYAMAGDVPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: MCFY_DICDI
Sequence: MENNNKNINTTNNSTTINTNNNNNPINKNNNNNNINNNNNNNINNINNINNVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNNNNNINNNNINKKNINNINKNKINNNNNNEIGEEKAVEGGFLAGLSRNVTRIIGSFSSGMAEESAGYPLDLIKTRIQLSQSGVSGGGGTNTSIIKIFKDVIKTEGVIGLFKGLSSPLILSALVTAIQFGLFEDTLKYFRKHQYFKNHDTLSLLFSGSIAGFAQSFITCPVDLVKIQMQIQGIPSSQPNSNNNNNNNKAKGNSYFTKLIYREKGLLGFYQGLSPTLFRDVPGLAIFFTTYETLKKQFGQPELSTQSPTEFIKSFIPIVLSGGSAGVFYHGLTHPFDIAKTLIQSDRSATKYKGTFDCLKQVYQNQGPKSLFKGFSAVAIKSFQSNAVGFLVYEMVINL
What is the function of this protein?
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.
What are the official names of this protein?
Mitochondrial substrate carrier family protein Y.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPPH_PSEFS
Sequence: MIDPDGFRPNVGIILTNDAGQVLWARRINQDAWQFPQGGINPDETPEDALYRELNEEVGLEREDVQILACTRGWLRYRLPQRLVRTHSQPLCIGQKQKWFLLRLISNEQRVRMDLTGKPEFDGWRWVSYWYPLGQVVTFKREVYRRALKELAPRLLARD
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: RL5_ROSDO
Sequence: MLDSANYTPRLKAVYRDTIRAALKEEFGYKNDMQIPRLDKIVLNIGCGAEAVRDSKKAKSAQADLTLIAGQKAMTTTAKKSIAGFRVREEMPLGAKVTLRGDRMYEFLDRLITIAMPRIRDFRGISGKSFDGRGNYAMGLKEHLVFPEIDFDKIDENWGMDIVIATTAQTDAEAKSLLKAFNMPFNS
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: CH60_CHLTB
Sequence: MVAKNIKYNEEARKKIQKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEVELADKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYTEGLRNVTAGANPMDLKRGIDKAVKVVVDQVKKISKPVQHHKEIAQVATISANNDAEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFATNPETQECVLEDALVLIYDKKISGIKDFLPVLQQVAESGRPLLIIAEDIEGEALATLVVNRIRGGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLISEELGMKLENANLAMLGKAKKVIVSKEDTTIVEGMGEKEALEARCESIKKQIEDSSSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALIRCIPTLEAFLPMLTNEDEQIGARIVLKALSAPLKQIAANAGKEGAIIFQQVMSRSANEGYDALRDAYTDMLEAGILDPAKVTRSALESAASVAGLLLTTEALIAEIPEEKPAAAPAMPGAGMDY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCN1B_PANTR
Sequence: MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
What is the function of this protein?
Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle.  Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation.  Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
What are the official names of this protein?
Sodium channel subunit beta-1.
What is the protein family that this protein belongs to?
Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection. Cell projection, axon. Note=Detected at nodes of Ranvier on the sciatic nerve.
Protein: ATPD_ASHGO
Sequence: MFRLTSARALFRVANVAARRTYAEAAADALKLNFALPHETLFAGTAVKQVNLPVKTGQIGILANHVPIVEQLVPGVVEVLEGSESKKFFVSGGFATVQPDSTLSITSVEAFPLDSFSAENVRALLAEAQKNAGAADSRVAAEASIQIEVLEALQAALK
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element.  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
What are the official names of this protein?
ATP synthase subunit delta, mitochondrial, F-ATPase delta subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: MURG_SINMW
Sequence: MDKGIILLAAGGTGGHLFPAEALAHELKASGYSVHLVTDSRAERFAGRFPADEIHVVASATIGSKNPVKLARSAWKLWTGLRAARRLISRLKPMAVVGFGGYPTVPPLLAATGMGVPTIIHEQNAVMGRANKMLASRVAAIAGGFLPEGTGAFAAKTVATGNPVRPAVLEAARVPYAPAGGDAPFHLVVFGGSQGAQFFSKAVPQAVCRLDDALRRRLKVTQQARPEDREGVIASYEKLDIPAEVSPFFTDMAGRIASAQLVICRSGASTVSEVSVIGRPAILVPYPYALDHDQAANAAALAAKGGARVIAQVELSAERLANILTDAMSNPDTLAQMAAGARQTGKAGAARLLALLVEAIASGSTVAKFKETRS
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DER_ACIBY
Sequence: MKPVIALIGRPNVGKSTLFNQITKSRDALVADFAGLTRDRKYGDATYQNKSFIVVDTGGIGESEGGIDNYMAEQSKTAINEADIIIFVVDARAGLLASDEQIARELRTLGKKIYLVANKVDGVHAEAALVEFYKLGMGEPLQVAASHGRGVQQMLEDVLQDIPEDENPEEHDKDTGLRLAIIGRPNVGKSTLVNRLLGEDRVVAFDQPGTTRDSIYIPFEREGRKYTLIDTAGVRRKGKVDEMIEKFSIVKTLQAMKDAHVVVVVVDAREGIVEQDLHLIGYALEAGRAMVIAINKWDNMSEYDRKQCKLDVERRFDFIPWARIHLISALHGTGVGELYPSIHRAYESANLKVSPAKLTQILNDATDQHQPPTVQGRRIKMRYAHMGGQNPPTIVIHGNKVDKTPADYRRYLENVFRKVYKLEGTPVKIEFKTSENPFEGRKSQVDERTAARRRRYIQKFKKAEKKFKR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RPOZ_DICTD
Sequence: MKEVNIDTLISKIPNKYVLTVVISKRARQLFEELKFLKTIARDPLILAMEEIAQEKIAYGEGDDLED
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RL28_EXIS2
Sequence: MARKCYVTGKSPKSGNNRSHALNKTKRTWGINVQKVRILVDGKPKKVWVSARALKSGKVERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: Y0614_DICDI
Sequence: MPSVNEFFIFFLIVWHTCECVGIGFEHLHLVIYLNLNLQNVRFYLMKLINHLIIEKSSLHLLISTIHSFIDILLSDFKCNSSTRKCTTGMSVDISKIYTAEYGHLKAKLDTIGGLYCDSKDVTIMKVYVLVPLTIVLNIQVL
What are the official names of this protein?
Putative uncharacterized protein DDB_G0280709.
Protein: FPG_RHIL3
Sequence: MPELPEVETVKRGLTPAMEGTRVTRLELRRGDLRFPFPDAFADRVSGRTIVGLGRRAKYLLVDLDDGNTLISHLGMSGSFRIEEGAASGVPGEFHHARSKDEKHDHVVFHLQAASGLRRVVYNDPRRFGFMDMVGRADLATHPFFRDLGPEPTGNELSAAYLAERFRDKAQPLKSALLDQKNIAGLGNIYVCEALWRSHLSPIRAAGTLVTAGGRPKAQLDLLVASIRDVIADAIAAGGSSLRDHIQTDGSLGYFQHSFSVYDRESQACRTPGCGGTVARIVQAGRSTFYCATCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: MTGA_ECOSM
Sequence: MSKSRLTVFSFVRRFLLRLMVVLAVFWGGGIALFSVAPVPFSAVMVERQVSAWLHGNFRYVAHSDWVSMDQISPWMGLAVIAAEDQKFPEHWGFDVASIEQALAHNERNENRIRGASTISQQTAKNLFLWDGRSWVRKGLEAGLTLGIETVWSKKRILTVYLNIAEFGDGVFGVEAAAQRYFHKPASKLTRSEAALLAAVLPNPLRFKVSAPSGYVRSRQAWILRQMYQLGGEPFMQQHQLD
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MCRD_METVO
Sequence: MIEIEVFPHRFLKATTTEKFLNSAYSLETVQRVIMHGESLPQKVNYGPAKGTPVNHSERKLINVQGVEVQLTLQVGRFWILLDDETELSKIDEICKELFQYGYKVSEGRFIKDSPTVTDYMKYGESFVNNIDKRMLGVTDPRSRFENSVSLIPKSEKGE
What are the official names of this protein?
Methyl-coenzyme M reductase operon protein D.
Protein: HA70C_CBCP
Sequence: MSLSIKELYYTKDKSINNVNLADGNYVVNRGDGWILSRQNQNLGGNISNNGCTAIVGDLRIRETATPYYYPTASFNEEYIKNNVQNVFANFTEASEIPIGFEFSKTAPSNKSLYMYLQYTYIRYEIIKVLQNTVTERAVLYVPSLGYVKSIEFNSEEQIDKNFYFTSQDKCILNEKFIYKKIDDTITVKESKNSNNNINFNTSQTILPYPNGLYVINKGDGYMRTNDKDLIGTLLIESSTSGSIIQPRLRNTTRPLFNTSNPTIFSQEYTEARLNDAFNIQLFNTSTTLFKFVEEAPTNKNISMKVYNTYEKYELINYQNGNIDDKAEYYLPSLGKCEVSDAPSPQAPVVETPVDQDGFIQTGPNENIIVGVINPSENIEEISTPIPDDYTYNIPTSIQNNACYVLFKVNTTGVYKITTKNNLPPLIIYEAIGSSNRNMNSNNLSNDNIKAIKYITGLNRSDAKSYLIVSLFKDKNYYIRIPQISSSTTSQLIFKRELGNISDLADSTVNILDNLNTSGTHYYTRQSPDVGNYISYQLTIPGDFNNIASSIFSFRTRNNQGIGTLYRLTESINGYNLITINNYSDLLNNVEPISLLNGATYIFRVKVTELNNYNIIFDAYRNS
What is the function of this protein?
The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of botulinum neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host (PubMed:9421908).  The HA component is involved in binding to the upper small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (Probable).  Whole protein and the HA-53 chain (but not the HA-22-23 chain) bind to bovine mucin; if the mucin is pretreated with neuraminidase (removes the terminal sialic acid of glycoconjugates) mucin binding is decreased (PubMed:19071137).  Has higher affinity for alpha-2,3-sialylated oligosaccharides than alpha-2-6 sialylated oligosaccharides (PubMed:22684008).
What are the official names of this protein?
Hemagglutinin components HA-70 type C, HA3, Hemagglutinin components HA-22/23/53 type C, Hemagglutinin components HA-22/23/53 type C1.
What are the subcellular locations of this protein?
Secreted.
Protein: PTPA_MYCTO
Sequence: MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
What is the function of this protein?
Supports mycobacteria survival during infection by modulation of the phagosome maturation and modulation of the normal host signaling pathways, including host innate immune responses and cell apoptosis.
What are the official names of this protein?
Low molecular weight protein-tyrosine phosphatase A, LMW-PTP, PTPase, Low molecular weight tyrosine phosphatase PtpA.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Protein: HA11_MOUSE
Sequence: MGAMAPRTLLLLLAAALAPTQTRAGPHSMRYFETAVSRPGLEEPRYISVGYVDNKEFVRFDSDAENPRYEPRAPWMEQEGPEYWERETQKAKGQEQWFRVSLRNLLGYYNQSAGGSHTLQQMSGCDLGSDWRLLRGYLQFAYEGRDYIALNEDLKTWTAADMAAQITRRKWEQSGAAEHYKAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHPRSKGEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVYHEGLPEPLTLRWEPPPSTDSYMVIVAVLGVLGAMAIIGAVVAFVMKRRRNTGGKGGDYALAPGSQSSEMSLRDCKA
What is the function of this protein?
Involved in the presentation of foreign antigens to the immune system.
What are the official names of this protein?
H-2 class I histocompatibility antigen, D-B alpha chain, H-2D(B).
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RPB11_YEAST
Sequence: MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAAYKVEHPFFARFKLRIQTTEGYDPKDALKNACNSIINKLGALKTNFETEWNLQTLAADDAF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB11 is part of the core element with the central large cleft.  Seems to be involved transcript termination.
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB11, RNA polymerase II subunit B11, B13.6, DNA-directed RNA polymerase II 13.6 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HTPX_BURL3
Sequence: MFNWVKTAMLMAAITALFIVIGGMIGGSRGMTIALLFALGMNFFSYWFSDKMVLRMYNAQEVDENTAPQFYRMVRELATRANLPMPRVYLINEDAPNAFATGRNPEHAAVAATTGILRVLSEREMRGVMAHELAHVKHRDILISTITATMAGAISAIANFAMFFGGRDENGRPANPIAGIAVALLAPIAGALIQMAISRAREFEADRGGAQISGDPQSLATALDKIHRYAAGIPFQAAEQHPATAQMMIMNPLHGGGLQNLFSTHPATEERIARLMEMARTGRFD
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPH_ANASK
Sequence: MDVKIAKTAGFCWGVRRTVDKVMEVADQHRAPVVTLGPIIHNPQAVARFSEKGVGTVNGIGEVTDGTTVVVRTHGAVREELERAEARGLEVVDGTCPYVKYPQAMAQRLSREGYHIVIVGDANHAEIKGVISYSEQPCTVVKPGGPVPEIKAKKVAVIAQTTCIGAEFERVVGVLALRHKEVRAVNTICNDTEERQADARALASEVDAVVVVGGKNSANTRHLAEICRAIQPRTWHVETEAELGAAWFEGCRVVGLSAGASTPDWVVEGVAAWLRALR
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: VE6_HPV39
Sequence: MARFHNPAERPYKLPDLCTTLDTTLQDITIACVYCRRPLQQTEVYEFAFSDLYVVYRDGEPLAACQSCIKFYAKIRELRYYSDSVYATTLENITNTKLYNLLIRCMCCLKPLCPAEKLRHLNSKRRFHKIAGSYTGQCRRCWTTKREDRRLTRRETQV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: SERB_SHIFL
Sequence: MPNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLGAAMVIVAAWCVEDYQVIRLAGSLTARATRLAHEAQLDVAPLGKIPHLRTPGLLVMDMDSTAIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRSRVATLKGADANILQQVRENLPLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVIGDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKAEVTIRHADLMGVFCILSGSLNQK
What is the function of this protein?
Catalyzes the dephosphorylation of phosphoserine (P-Ser).
What are the official names of this protein?
Phosphoserine phosphatase, PSP, PSPase, O-phosphoserine phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. SerB family.
Protein: LIGB_AZOVD
Sequence: MQRRIAFSLLLLLPFASPALADSACPDWTAQRAAAELAALAERLRQWDVAYHRDGRSPVADELYDQARARLADWNRCFPGQADASPEPLAGSAGPLLHPVPHTGLAKLDEAAVRDWMATREDLWTQPKVDGVAVTLEYADGRLRRAISRGDGRHGQDWTARVRRLPALPRQLAERRRLILQGELYWRLPGHVQAEAGGRSARARVAGLLARDTLDDGDAAGIGLFVWDWPNGPADMRARLDGLERLGFAEARRYSRPVADFATARQWRERWYREPLPFASDGVVLRQGRRPPGERWRAEPPHWAVAWKYPLAQALAEVRAVRFRIGRSGRITPQLELQPVRLDDRQIRRVALGSLRRWRELDVRPGDQVAIRLAGQSIPQVDAVVWRAAERPALPSPDPAAHHALSCWRPLPGCEEQFLARLDWLGGRRGLDLRGVGRGTWEALLENGRLDDLLGWLELDEARLAELPGFGERSASLLAERFRAARRRPFPMWLRALGLPPAGEATLPPSWDELAGRGPEQWQREPGIGPGRARQLQAFFAHPEVQALRQRLRAAGVEGF
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Protein: RT12_CHOCR
Sequence: MPTFKQLLKKPRKIVLTKSKSIALIQCPQKKGICMKVYTTSPKKPNSAERKVAKVNLTNGKSIIGYISGEGHTLQEHSLVLVRGGRVKDLPGVQYHFVRGVYDLHAVGTRKKSRSKYGKKLFKAPIV
What is the function of this protein?
Protein S12 is involved in the translation initiation step.
What are the official names of this protein?
Ribosomal protein S12, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL27_CUPTR
Sequence: MAQKKGGGSTRNGRDSESKRLGVKVFGGQAINAGGIIVRQRGTRVHAGDNVGVGKDHTLFALIDGHVQFAVKGPAKKQQVSVVPAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RS14Z_FRACC
Sequence: MAKKALIEKSNRKPKYAVRGYTRCQRCGRSRSVYRGFGLCRVCLRQMAHRGELPGVTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.