PharMolix/UniProtQA huggingface dataset:
Protein: RUVC_YERE8
Sequence: MAIVLGIDPGSRVTGYGVIRQQGRQLTYLGSGCIRTVVDDMPTRLKLIYAGVTEIITQFQPDFFAIEQVFMAKNPDSALKLGQARGAAIVAAVNLNLPVSEYAARQVKQTVVGTGAAEKSQVQHMVRSLLQLPANPQADAADALAIAITHCHLSQNTLRLGNDQMVLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: HUTI_PSESM
Sequence: MKTLWKHCHIASMAHGKYSIIEDAAIVTSGALIEWIGPQAELAEPEHDNCIDLGGAWVTPGLIDCHTHTVFGGNRSGEFEQRLQGVSYAEIAAAGGGIASTVRATRAASEDELYASAERRLRHLLKDGVTTVEMKSGYGLDLENERKILRVIRRLGNTQPVTVRATCLAAHALPPEYADRADDFINHICNEMLPALAAEGLVDAVDAFCEYLAFSPEQVERVFITAGQLALPVKLHAEQLSSLGGSSLAARYNALSADHLEFMTEDDAIAMAAAGTVAVLLPGAFYFLRETQLPPMDALRKHGVPIAISTDLNPGTSPGLSLRLMLNMACTLFRMTPEEALAGVTFNAAKALGMSATHGSLEVGKVADFVAWNIERPADLGYWLGGDLDKRIVRHGVESSI
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_CLOB1
Sequence: MSKLDEKKQLKCSFCGKTQDQVRRLIAGPGVYICDECIELCSEIINDEFEDDIQVDLTSLPKPTEIKTYLDQYVIGQEDAKKSLSVAVYNHYKRINSNTNNDDVELQKSNILLLGPTGSGKTLLAQTLAKFLNVPFAIADATTLTEAGYVGEDVENILLKLIQNADYDIEKAEKGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVAAVPPQGGRKHPHQEFIQINTTNILFICGGAFDGVDKIIERRTRTSSLGFGAEIQSKKEKDLGKLLKDIMPGDLLKFGLIPEFIGRLPIVVTLDKLDREALIKILTEPKNALVKQYKKLFELDDVELEFNQEALKEIADEAINRNTGARGLRAIIEDMMREIMFDIPSQENIGKVIVNEDCIKTKKPELIEAEGGKRLPIKPKKGKKRKDSETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: YORA_BPP1
Sequence: MEPVPRELIEHMEDGLVVTEQTMATNEALQPFFNSDELFRRIGGIDALVAWLRRKEGQCQAADRSWCDNHIVHAERDNSAVLLCWHHDNHYRMRGFNELKETLHNNRVNWILDVARQEMGLSNSHDLSIQELCWWAFMRNMMHLMPEEVCRISINKMKATPQDSGPLKEADIRPYDDRATAYVQMMEERSAPMRAKVCPVDVDSDPGMAHFKIPKLQSLKLPEYMDFVASRPCCGCGAAGRGAHITPYIVRHSRLCAHDIYAIPLCQSCQRDIERDRYNWEKTHGRLAMHQRLFFDYALGVGVITSHSSSVR
What are the official names of this protein?
Uncharacterized 36.0 kDa protein in doc-Gp10 intergenic region, ORFA.
Protein: MFR1L_PONAB
Sequence: MSEMEASVTIPIWQNKPHGAARSVVRRIGTNLPLKPCARASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPSVPLLCSASPECCKPEHKAACSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLNRSLLKEEDPAVLISEVLRRKFALKEEDISRKGN
What are the official names of this protein?
Mitochondrial fission regulator 1-like.
What is the protein family that this protein belongs to?
Belongs to the MTFR1 family.
Protein: METN_LATSS
Sequence: MLELKQVGKVYQREQQTFTALSDISLKIEAGEIYGIIGYSGAGKSTLIRLLNGLEKPTSGDVLVNGQSIVGLSEQAMRPIRQKIGMIFQHFNLLWSKTILENIALPLKLAGVGKKERLAKAKEMLALVELTDLGAAYPSELSGGQKQRVAIARALISEPAILLCDEATSALDPKTTNSILSLLAKINQEMGITIVLVTHEMDAVRRICQRIAVMAAGRVIEEGTTQAIFETPQAEVTKAFVSESLVITPSETAASIEQLLTRVPEGTIIKLRFNEEQSSQPVIGQLMRRYPSVEVSVISGSLQQTINGALGYLYIQIQASPDDLKQALSDLSQQTIEVEVLRHG
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PYRE_PROM1
Sequence: MNPLNPSSDGIKENLLTLLAQKAYRFGDFSLASGKKSSHYVNCKPVSLSGPGLLSISSLFLKQINESDSGVAGLTLGADPLVSGVVILAAQSGIDLNGLIVRKEAKGHGTGAWLEGPLPPKGSVITVLEDVVTTGGSSLKAVEQLRNQGYLVKQVLAIVDREEGGLDAISKADLELNSLFFLKEIVERANSLQ
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: SECA_THET2
Sequence: MLGLLRRLFDNNEREIARYYKQVVEPVNRLEAEVEKLPDLAAAYRELKEKHEKGASLDELLPMAFALTRESAKRYLGMRHFDVQLIGGAVLHEGKIAEMKTGEGKTLVATLAVALNALTGKGVHVVTVNDYLARRDAEWMGPVYRGLGLSVGVIQHASTPAERRKAYLADVTYVTNSELGFDYLRDNMAISPDQLVLRHDHPLHYAIIDEVDSILIDEARTPLIISGPAEKATDLYYKMAEIAKKLERGLPAEPGVRKEPTGDYTVEEKNRSVHLTLQGIAKAEKLLGIEGLFSPENMELAHMLIQAIRAKELYHRDRDYIVQDGQVIIVDEFTGRLMPGRRYGEGLHQAIEAKEGVRIERENQTLATITYQNFFRLYEKRAGMTGTAKTEEKEFQEIYGMDVVVVPTNRPVVRKDFPDVVYRTEKGKFYAVVEEIAEKYERGQPVLVGTISIEKSERLSQMLKEPRLYLPRLEMRLELFKKASQKQQGPEWERLRKLLERPAQLKDEDLAPFEGLIPPKGNLRTAWEGLKRAVHTLAVLRQGIPHQVLNAKHHAREAEIVAQAGRSKTVTIATNMAGRGTDIKLGGNPEYLAAALLEKEGFDRYEWKVELFIKKMVAGKEEEARALAQELGIREELLERIREIREECKQDEERVRALGGLFIIGTERHESRRIDNQLRGRAGRQGDPGGSRFYVSFDDDLMRLFASDRVIAMLDRMGFDDSEPIEHPMVTRSIERAQKRVEDRNFAIRKQLLQFDDVLSRQREVIYAQRRLILLGKDEEVKEAAIGMVEETVASLAENFLNPEVHPEDWDLEGLKATLLDTAPQLQDFPFAELRALKAEEAVERLVEAALKAYEAREAELSPPLMRAVERFVILNVVDNAWKEHLHNLDVLRQGIFLRGYGQKDPFQEYKIEATRLFNEMVAFIKSEVAKFLFRLKVEAEPVRPVREAPYVPVPEAKPEPSEVFGVERKRATPPPQPGLSRAERRRLMRQEKKRKK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CWC23_ASHGO
Sequence: MSADALKDVIGGGKDLYALLEVSISSPEELEAVDAAQLRAQFRRLALRYHPDKRRDDTQQNDKFVSVQKAYDILSNSSLRATYNRWLSCRLFGDPERRRLVRELHQREQLQVRQKEPMDKDIQNIQSYGQLLRKMRHLRIPYGDWRPNTSISRDSTLVETCTLRLLLRQNSTTNSKSSMLQLFQRAKLHIVDLYFSSRNVDTENDLVLYAVMPDVDTMLDLLNNWAVKPPLSEHILQVQPRVHTDYFHFKTDISLDKTITEAIDADNQYMSSF
What is the function of this protein?
Involved in pre-mRNA splicing.  May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CWC23.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EFP_LISMF
Sequence: MISVNDFKTGLTIEVDNGIWRVLDFQHVKPGKGAAFVRSKLRNLRTGAIQEKTFRGGEKVAKAQIDNRKMAYLYADGTNHVFMDNESYEQIELPEDQIAHELKFLKENMEINIIMYQGETIGIDLPNTVELVVTATDPGIKGDTSSGGSKPATLETGLVVQVPFFVNEGDKLVINTTEAAYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDD_VIBPA
Sequence: MKSRIEQALASAPEALSKQLAPIVLADDFDATLSAQQFEQLLSATSLSDKELRVALLPFAAAYSYAPISEFYVGAIVRGLSGRLYFGANMEFFGVQLGQTVHAEQSAISHAWMKGEHGVKDITINFSPCGHCRQFMNELSTAKELKVQLPERDEKSLHEYLPEAFGPADLGIESGLMAEVKHQFVCDDKDALIQQAVEAMNMSHAPYTNNLSGLALELANGRVFKGAYAENAAFNPSLPPLQVALIQVLLAGETFDSIKAAALVENSEGKISHLADTQSTLEALNPDIPVSFVNV
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: TRPF_PYRIL
Sequence: MLVKICGVARPEDVALLDGLVDYIGFIVEPSSPRSVEPRRLGELVRLVRESRPVLVTASLPPAEAVDLAASLGIPVVQHHGSLGDGHFSYAEERGVALAPVAVYRRGADLRAAVSQLLSKPHEYVLVDAEKGSRERYEGGLKIPLQALAEVAHMGKVALAGGITPENAHLVAALRPYMVDVASGVESSPGVKDPGKVKALLRALGRLSG
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: QUEC_STRT1
Sequence: MKRQSALVVFSGGQDSTTCLFWALKHYETVELVTFAYGQRHSLEIEVAKEIAQEQGLKHHVLDMSLLGQITENALTSDIEIEAEKGEVPNTFVDGRNHLFLSFAAVLAKQRGIIDIVTGVCETDFSGYPDCRDVFVKSLNVTLNLAMAYDFVIQTPLMWLDKAETWALADQLGAFDYVREKTLTCYNGIIGTGCGDCPACHLRQKGLEKYLAEKGDA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: CMR7A_SACS2
Sequence: MTSGAGWEEQVFLPITNSISSEDNNQIKIGSSVSIEYNQNGQHVSQIDDKGLHNILVLTGYAIDESTGELVPTFDPCDYVKGILISGKILKGNHFKIIGIPSNKLYIIRKKDVHGNITFSLPIKNFNTGTYQVDLRDKVTSFVSLDRDVAKTIVDNVLAKIYAKIYNSLNKEQKDKLYRDVEEIFNYYSIKSLKSNP
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).  The CMR complex degrades RNA complementary to the crRNA (target RNA) within UA dinucleotides, generating 3'-OH and 5'-phosphate ends.  Activity is dependent on the 8 nt long 5' tag in the crRNA, an unpaired 3' flag on the target RNA, and is stimulated by ATP.  Some cleavage of the guide crRNA can also be observed.
What are the official names of this protein?
CRISPR system CMR subunit Cmr7 1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR system Cmr7 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLME_AZOSB
Sequence: MKRNKTSKAWMHEHLNDTYVQRANAEGYRARAAYKLMEIDERDRLLRPGRVVVDLGAAPGSWCQVARQRVGSDGRVLALDILPMDPVPGVDFLQGDFTEDAVLAELESRLAGAAVDLVLSDMAPNLSGVATVDQARSIYLCELALDFARRHLKPGGQFLVKVFQGEGFMGFRKAMDEVFLSVQVRKPKASRDRSAEVYLLGVDLR
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_OLEA2
Sequence: MVMTPEKKMSIIEEYGQHEGDTGSPEVQVALLTARIEYLTEHFKSHKQDYHSRTGLLKLVGQRRNMLKYLAKKDVQRYRALIQKLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: 4FTAS_STRCT
Sequence: MPSSVNRTSRTEPAGHHREFPLSLAAIDELVAEEEAEDARVLHLTANETVLSPRARAVLASPLTSRYLLEHLDMRGPSPARLGNLLLRGLDRIGTIEESATEVCRRLFGARYAEFRCLSGLHAMQTTFAALSRPGDTVMRVATKDGGHFLTELICRSFGRRSCTYVFDDTMTIDLERTREVVEKERPSLLFVDAMNYLFPFPIAELKAIAGDVPLVFDASHTLGLIAGGRFQDPLREGADLLQANTHKTFFGPQKGIILGNDRSLMEELGYTLSTGMVSSQHTASTVALLIALHEMWYDGREYAAQVIDNARRLAGALRDRGVPVVAEERGFTANHMFFVDTRPLGSGPAVIQRLVRAGVSANRAVAFNHLDTIRFGVQEITRRGYDHDDLDEAADLVAAVLLERQEPERIRPRVAELVGRRRTVRYTGDPASAAGPPARERYAPPTAPAGHPARPRWIGVRLTPLPEPVTEAECAGAQRLGRLAGAFPHQIDSSGNVSFTSTDGRLFVTGSGTYIKDLAPGDFVELTGAEGWTLHCRGDGPPSAEAYLHHLLRERVGARYVVHNHCIPGRALETSGALVIPPKEYGSVALAEAVADACQDSQVMYVRRHGLVFWAHSYDECLALIEDVRRITG
What is the function of this protein?
Transaldolase that catalyzes the final step in 4-fluorothreonine biosynthesis.  Mediates a L-threonine/fluoroaceldehyde to 4-fluoro-L-threonine/acetaldehyde crossover reaction.  Can also convert chloroacetaldehyde into 4-chloro-L-threonine.  Does not use glycine as a substrate.
What are the official names of this protein?
Fluorothreonine transaldolase, 4-fluorothreonine transaldolase, 4-FTase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
Protein: APGM_THEP1
Sequence: MFDKQEFVSKLVTEEKAKIVLLVMDGLGDIPVNGKTPLQAANTPNLDSLAKESDLGQTIPVLPGITPGSGPGHLSLFGYDPIRYQIGRGILEALGIGVEVGEKDVVARANFATWDGKVVLDRRAGRPATEESAKVVQLLSEKIKKIEDVEITFYPGKEHRFVVKFTGEGLGDNVTDADPQKEGHPMVWAEGLDEPSKKTARITNELIKKIAEVLKDNPKINFALIRGFSKYPDLPKFPQVYKMKAGAIATYPMYRGLAKLVGMEIIETGQTVADEIKTLKERWNDYDFFYVHVKKTDSYGEDGKFEEKVKVIEEVDALIPEIVSLNPDVLVITGDHSTPVPLKAHSWHPVPLLIWSKYTRRGLSQAFNEFECARGTLGTIHASDVMTLALAYAGKLEKFGA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, aPGAM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Protein: MRAZ_SHESA
Sequence: MFRGASAINLDTKGRIAIPVRYREPLQLEHQGRIVITVDIQSACLLLYPIHEWELIEAKLLKLSDTDKTQRSLKRMLLGYAHEVELDGNGRILLPPPLRQYANLDKRIMLVGQLNKFELWDEQAWLQQIDECQETIRSEELANNERLADFSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PTH_SHEB5
Sequence: MSEIKLIVGLANPGAEYAHTRHNAGAWYVLELARICGVTLVADSKYFGLTARAVLHGKDVRLLIPTTYMNLSGKAVGALANFFRITPEEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRLGIGHPGDKNQVSGYVLGKAPAKEQELIDAAIDEAVRSTEILFKQDMVKAMNRLHSFKAE
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_CAMHC
Sequence: MFENQLEIQRIQKADELRNLGVNPYPHFLKKDMNIKEFREKFAYIAENETKKADEEIVISGRIKLKRVAGRSTFANIEDESGNVQIYYSKDSIGEENYLKFKKNIEVGDIILVKGYAFLTGTGEFSIHVSDLILASKAISILPEKFHGLADKELRYRQRYLDMIMDPSVRVDFEKRSLIVRTIRRFFEDRGFLEVETPMMHQIAGGANAKPFITHHNALDIDRYLKIAPELYLKRLVVGGMNSVFEMNRCFRNEGMDLTHNPEFTSIEFYWAWHNYFEAMDLTEELFNELLKTLNLGEILDYGNLKIDFSKKFQRIKYLDALVLIGEISPEIIKDKDEILKKLKSDGFEANEKLDLGHLQAELFDNYVESKLINPTFITDFPVSISPLSRRSDKDPEIAERFELYIAGKELANAFNELNDPLDQYERFKAQIEAKKAGDDEAHEMDEDYVRALSYAMPPTVGWGLGVDRLVMILLNKASIRDVILFPAMKPIKNLDDKE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_HYDS0
Sequence: MKEYALEIATKAKAVLPKLSSLNPAVKNSILIRVSQLLKENKELIQKENEKDIEFAKSINLSKAMIDRLKVGEKQINGMIKILEDVAKLKDPVGEITSMWTVDNGLKIGRMRVPLGVIFIIYESRPNVTIEAASLCFKSSNAVILRGGKEAIHTNKILSDLFRQAIREHVEGLEDAVCFVDKREREIVTELLQLEGLVDVAIPRGGESLIKAVSETAKISVIKHYKGVCSIYVDNEADLKKAYNIVYNAKVQRPSVCNAIENLVIHKDLLQDFWPKMAMVLLESDVELRCDEDSYEILQNKDFDSFKSKIKKATEKDYYEEFLDLILAVKTVNSLEEAMQFIEKYGSKHSDAIITENHTKAMRFLQEVDSAAVYVNASTRFTDGNEFGLGAEMGISTDKIHARGPMALRELTIEKFIIFGNGQLRENVGIPKELKEKLQID
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_PSEP1
Sequence: MSKQPSLSYKDAGVDIDAGEALVERIKGVAKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDSIGQDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSKVATGDALIALPSSGPHSNGYSLIRKILEVSATDIENTQLDGKPLTDLLMAPTRIYVKPLLQLIKNTGAVKAMAHITGGGLLDNIPRVLPKNAQAVVDVASWQRPAVFDFLQEKGNVDEHEMHRVLNCGVGMVICVAQDQVEAALNELRAAGEQPWVIGHIAEAAEGAAQVELQNLKAH
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHEU_SHIDS
Sequence: MLITWQDLSPETLENLIESFVLREGTDYGEHERTLEQKVADVKRQLQCGEAVLVWSELHETVNIMPRSQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: ERD2_PLAF7
Sequence: MNIFRLIGDILHLVSMYILIMKLKKSKNCIGISCRMQELYLIVFLCRYIDLFFVFVSFYNTVMKITFILTIAYTIYLIRLKLPISQTYNRKVDNFKSEKYLIPPCLVLSLLTCKTYNLYNILWSFSIWLESVAILPQLVLLEKQREVENITSHYVITMGLYRAFYILNWIYRYFFDDKPYINVVGWIGGLIQTLLYIDFFYYFALAKWYGKKLVLPFNGEV
What is the function of this protein?
Required for the retention of luminal endoplasmic reticulum proteins.  Determines the specificity of the luminal ER protein retention system.  Also required for normal vesicular traffic through the Golgi (By similarity).
What are the official names of this protein?
ER lumen protein-retaining receptor.
What is the protein family that this protein belongs to?
Belongs to the ERD2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RM04_ASPNC
Sequence: MNRQSVLRLARQTGAFPLAELPPPYLAPSLHFSMNRSTVQCSNFSSTAAVAAGRGDLNKVRGVSAIHRTGPKYKLGVSKYPLPKPVSPDALPKRNATPDHGLWGFFPTDRTALSTPTYDIECGRSWSIQELREKSWDDLHSLWWVCVKERNRIATSDMERKRLKAGYGEWESSERDRVIRVTQNGIKHVLRERWYAWEEAQRLYRKGYRPQEDSQEAIWEMRADSVSNSQGAGQLLVVSKAEDMIDPLRHDRWEKGQEENSGGETEDGNAPSN
What are the official names of this protein?
54S ribosomal protein L4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CLC4E_HUMAN
Sequence: MNSSKSSETQCTERGCFSSQMFLWTVAGIPILFLSACFITRCVVTFRIFQTCDEKKFQLPENFTELSCYNYGSGSVKNCCPLNWEYFQSSCYFFSTDTISWALSLKNCSAMGAHLVVINSQEEQEFLSYKKPKMREFFIGLSDQVVEGQWQWVDGTPLTKSLSFWDVGEPNNIATLEDCATMRDSSNPRQNWNDVTCFLNYFRICEMVGINPLNKGKSL
What is the function of this protein?
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766).  The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491).  Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity).  Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity).  Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (By similarity).  Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (By similarity).
What are the official names of this protein?
C-type lectin domain family 4 member E, C-type lectin superfamily member 9, Macrophage-inducible C-type lectin, MINCLE.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cell projection, phagocytic cup.
Protein: SC31_TITOB
Sequence: CSTCLDKP
What are the official names of this protein?
Toxin To31, Toxin Tc31.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP8_SALSA
Sequence: MPQLNPAPWFAILVFSWLVFLTVIPPKVLGHTFTNEPTSQSTEKAKPEPWNWPWH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.