PharMolix/UniProtQA huggingface dataset:
Protein: COAD_STRS2
Sequence: MSDKIGLFTGSFDPITNGHLDLIERASGLFDKLYVGVFTNPKKAGLLTGLERKAILEKLFVGMENIEVVLSENELVVDVAKRYGVTHLVRGLRNATDLEYESSFDFYNRQLAPGLETIYLIAKPELKFVSSSQVRELLYFKQDIGPYVPEIVSEEIRKNEEK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLMA_SALCH
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKNTSTRLRLIVLLILGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYTTDENLLASQLLAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: LCPA_CORGL
Sequence: MTEKYRPVRDIKPAPAAMQSTKQAGHPVFRSVVAFVSVLVLLVSGLGYLAVGKVDGVASGNLNLGGGRGIQDGNAADGATDILLVGSDSRSDAQGNTLTEEELAMLRAGDEENDNTDTIMVIRVPNDGSSATAVSIPRDTYIHDDDYGNMKINGVYGAYKDARRAELMEQGFTNESELETRAKDAGREGLIDAVSDLTGITVDHYAEVGLLGFVLLTDAVGGVEVCLNNAVDEPLSGANFPAGRQTLGGSDALSYVRQRHDLPRGDLDRIVRQQSYMASLVNQVLSSGTLTNPAKLSALADAVTRSVVIDEGWEIMSFATQLQNLAGGNVTFATIPVTSIDGTGDYGESVVTIDVNQVHAFFQEALGEAEPAPEDGSDDQSADQAPDLSEVEVHVLNASYVEGLANGIAAQLQELGYSIAETGNAAEGLYYESQILAAEEDSAKALAISEALGGLPIVANSSLDDNTVIVVSAGDYAGPTAEANAVTSSTVGQPGADVGEPIESPEFDAGGDGPRCVN
What is the function of this protein?
Involved in cell wall biosynthesis.  May be responsible for the transfer of arabinogalactan onto peptidoglycan.  In vitro, has pyrophosphatase activity.
What are the official names of this protein?
Cell wall biosynthesis protein LcpA.
What is the protein family that this protein belongs to?
Belongs to the LytR/CpsA/Psr (LCP) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Note=Localizes at regions of strong cell wall biosynthesis, such as the poles and the division plane.
Protein: MYT3_MYTCA
Sequence: MLKGIILIVTIQLVNANFFGVFGKPLYNPFNKDKYMIDFITTFNKLMNMKQPQFPHPKSYPGFPPLFPGIKGKKSVFKTIDFTDMAPGSKKTFRVDNGQGIAFRSKSGNAGGMSFSSGTGGGKGFAFGGTLGGGSNGEFVMSQSGPGLKGGKVTYSKGVPKFAKGLFGMLPFFK
What are the official names of this protein?
Mytilin-3, Mytilus uncharacterized protein 3, MUSP-3.
What are the subcellular locations of this protein?
Secreted.
Protein: COWN_DENA2
Sequence: MCNCKKNIKVDESYVSFKDIDCFENACLVIDNLLRILKEPKNTNAYWEKFIEKIPEAYYTRDSKKDPSEALLYLVCSCTSNIMELFEEIDDEEAIDAMSKCEQECC
What is the function of this protein?
Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO).  Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.
What are the official names of this protein?
N(2)-fixation sustaining protein CowN, CO weal-nitrogenase.
What is the protein family that this protein belongs to?
Belongs to the CowN family.
Protein: PSAA_PROMT
Sequence: MTISPPEKEQKKEPVLDKPIETDAIPVDFSKLDKPGFWSKSLAKGPKTTTWIWNLHADAHDFDTHVGDLQETSRKVFSAHFGHLAVIFIWMSAAFFHGARFSNYSGWLSDPTHVKPGAQVVWPIVGQEMLNADLGGNYHGIQITSGIFQMWRGWGITNETELMALAIGALLMAAIMLHGGIYHYHKAAPKLDWFRNLESMLNHHIAGLVGLGSIAWAGHCIHIGAPTAALMDAIDAGKPLIIDGIPIASIADMPLPHELCNPAIASQIFPGLAGRTVENFFTTNWWAFSDFLTFKGGLNPVTGSLWMTDISHHHLAFGVLAVLGGHLYRTMFGIGHSLKEILDNHAGDPILFPAPNGHKGIYEFLANSWHAQLGLNLAMIGSLSIIISHHMYAMPPYPYLSIDYPTVLGLFTHHMWIGGLFIVGAAAHAGIAMIRDYDPAVHIDNVLDRILKARDALISHLNWACMFLGFHSFGLYIHNDVMRALGRPADMFSDTGIQLQPVFAQWIQNIHNSAAGSTTLAGANVSLQPGLVSEVFNGSVSQVGGKIGIAPIPLGTADFMIHHIHAFTIHVTLLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSSWDHVFLGLFWMYNGLSVVIFHFSWKMQSDVWGLTGGNFAQSSITINGWLRDFLWAQSSQVLTSYGQPISMYGLMFLGAHFVWAFSLMFLFSGRGYWQELFESIIWAHNKLNLAPTIQPRALSITQGRAVGAAHFLLGGIATTWAFFHARLIGLG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: H4_MYTED
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CYB_CHANE
Sequence: MTIMRKSHPLMKMVNHAFIDLPAPSNISSWWNFGSLLGLCLIIQIASGLFLAMHYSSDTTLAFSSVAHICRDVNYGWLIRYIHANGASLFFICLYLHIGRGIYYGSYMYKETWNIGIALLFLTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGTSLVEWIWGGFSVDKATLTRFFAFHFILPFIIAATAMVHLLFLHETGSNNPLGIPSNSDKIPFHPYYTFKDLLGMIIILAMFLTFVLFFPDLLGDPDNYSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVIALVLSILVLALFPFLHTANQRSMMFRPISQLLFWTLVSDLMILTWIGGQPVEPPFIIIGQIASILYFSIILIFLPIAGLIENKILKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SIGA_KITAU
Sequence: MPPPRTRGAESGGAGPSADLFRQYLREIGRIPLLTAAEEVDLARRVEAGLFAEEKLGGAADLDSQLAVDLDRLVVMGRMAKRRLIESNLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTAEEVAVHLELTPERVLEVLRLAQEPVSLHAPVGEEDDVALGDLIEDGDAASPVESAAFFLRCEHLEAVLSTLGERERKVVQLRYGLADGRPRTLEEIGRIFGVTRERIRQIESKTLNKLRDHAFADQLRGYLD
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth (By similarity).
What are the official names of this protein?
RNA polymerase sigma factor SigA.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYOU1_XENLA
Sequence: MRPLVCVLWMFLFALLSSHTESVAVMSVDLGSEWVKVAIVKPGVPMEIVLNKESRRKTPAAIALKENERLFGENALGMAVKNPKVTFRYFQDLLGKRLDNPQVQAFEARFPEYHLVKDERRETVLFKLSEDLTYSPEELLGMVLNYSRSLAEDFAEQPVKDVVITVPAFFNQAERRAVLQAAQLSGLKVLQLINDNTAVALNYGVFRRKDINATAQNVMFYDMGTRSTICTIVTYQTIKTKDSGTQPQLQIRGVGFDRTLGGLEIDLRLRDHLAKLFNEQKKSKKDVRENQRAMNKLLKEANRVKTILSANNDHMAQIEGLMDDIDFKAKVTRQELEDLCADLFNRVSAPVQQALASAEMKMEEIDQVILVGGATRVPKVQEFLLKVVGKEELSKNINADEAAAMGAVYQAAALSKAFKVKPFIVRDAAIFPIQVEFTREVEEENHSKSLKHNKRILFQRLAPYPQRKVITFNRYTDDFAFSINYGDLSYLGPEDLKVFGSLNLTTVKLNGVGESFQKRSDYESKGIKAHFNMDESGLLTLDRVEAVFETVADEKPELESTLTKLGNTISSLFGGGSSVSETKENVTDSVQEEDEVPTEPTKEEEQESADPADKQQDKENNKEKGTSATNEKEEGKKEEEKAEPQE
What is the function of this protein?
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation.  May play a role as a molecular chaperone and participate in protein folding.
What are the official names of this protein?
Hypoxia up-regulated protein 1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: OGT_ARCFU
Sequence: MFSVKWGELYFNVVMEGGKAVKSYFSTYPSFSSSDSEYARQLERYFSGERVEVRIPYRLKASSFTRRVLEEVSRIPYGMVRMYSDIAKALNTSPRAVGQAVKRNPLPVIIPCHRVVGKKEIGGYTVSCSDIDGKSLKKRLLRLEGVF
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CWP36_TOBAC
Sequence: VNDGYLDNGLQEGDFE
What are the official names of this protein?
36 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RSMH_HYPNA
Sequence: MSLRTTPRSPAEPGHLPVMLAEVLTALAPADGEVIVDGTFGGGGYTTAILKAANCTVLGIDRDLDAIVRAEKMAQANPRLVPLLGCFGDLDTLAEQAGHASVDGVVLDIGVSSFQIDQADRGFSFMKDGPLDMRMGGSGPSAADVVNTMSEKGLADVIFRLGEEKNSRRIARVLVQRRVQAPFETTADLAAVVEEAVGGRRGARSHPATLTFQAIRMYVNDELGELARGLRAAERILKPGGRLVVVTFHSLEDRLVKQWLRERAGAVPGGSRHMPLMSKGPAPAFELQENKAVQPSEKEVETNPRARSAKLRAAIRTNADAALDEASDGMNLPPLAELEKSR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACG_LEGPA
Sequence: MNNQQKIKCPICGKQNTWSPDNQFRPFCSERCKLIDLGEWASESRKIPGSSIDPESIVTSNNKQDNEDEQ
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: NRFA_VIBVU
Sequence: MSIKHWMASSVSVTALVMTALLNITAVSAEEKGLVDPRNDAFEQNHPDQYQSWKKTSESVEIEDALAEDPNMVILWAGYGFAKDYNKARGHFYALDDVRQTLRTGGPQDAKSGPMPMACWSCKSPDVARVIDERGEDGYFEGKWARLGAEIANPIGCADCHDTRSEKFKNGEPELALTRPYVERAFQAINKPFEQQSRLDKQASVCAQCHVEYYFTGPTKAVKFPWDMGTGVQQMEEYYDALGFADWTHAVSKAPMLKAQHPGFETWREGIHGKNKVVCVDCHMPKVKKEDGTVYTDHKVGNPFDRFEDTCAQCHTQSKDQLREIVSTRKAQVLNMKLTAEKQIVAAHFEAGAAWKAGATEEEMKPILQDIRHAQWRWDYAIASHGVHMHAPEVALEVLGTAVDRAADARTKLVRLLATKGITEPVQIPDISTKAAAQKALGMDMEKMNAEKQHFLKTVVPDWDKAAAERESKY
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GAG_HV2KR
Sequence: MGARSSVLRGKKVDELEKIRLRPGGKKKYRLKHIVWAANELGKFGLAESLLESKEGCQKIITVLDPLVPTGSENLKSLFNTVCVIWCLHAEEKVKDTEGAKQIVQRHLVAETGTADKMPSTSRPAAPPSGRGGNYPVQQIAGNYSHVPLSPRTLNAWVKLVEEKKFGAEVVPGFQALSEGCTPYDINQMLNCVGDHQAAMQIIREIINEEAADWDVQHPIPGPLPAGQLREPRGSDIAGTTSTVEEQIQWMFRAQNPIPVGNIYRRWIQIGLQKCVRMYNPTNILDVKQGPKEPFQSYVDRFYKSLRAEQTDPAVKNWMTQTLLVQNANPDCKLVLKGLGMNPTLEEMLTACQGIGGPGQKARLMAEALKEALAPAPIPFAAAQQRRTIKCWNCGKDGHSARQCRAPRRQGCWKCGKSGHVMANCPERQAGFLGIGPWGKKPRNFPVTRVPQGLTPTAPPADPAADLLEKYLQQGRKQKEQKMRPYKEVTEDLLHLEQGETPHKEATEDLLHLNSLFGKDQ
What is the function of this protein?
Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
What are the official names of this protein?
Gag polyprotein, Pr55Gag.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane; Lipid-anchor. Host nucleus. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion.
Protein: AAT1_ARATH
Sequence: MALAMMIRNAASKRGMTPISGHFGGLRSMSSWWKSVEPAPKDPILGVTEAFLADPSPEKVNVGVGAYRDDNGKPVVLECVREAEKRLAGSTFMEYLPMGGSAKMVDLTLKLAYGDNSEFIKDKRIAAVQTLSGTGACRLFADFQKRFSPGSQIYIPVPTWSNHHNIWKDAQVPQKTYHYYHPETKGLDFSALMDDVKNAPEGSFFLLHACAHNPTGVDPTEEQWREISQLFKAKKHFAFFDMAYQGFASGDPARDAKSIRIFLEDGHHIGISQSYAKNMGLYGQRVGCLSVLCEDPKQAVAVKSQLQQLARPMYSNPPLHGAQLVSTILEDPELKSLWLKEVKVMADRIIGMRTTLRESLEKLGSPLSWEHVTKQIGMFCYSGLTPEQVDRLTSEYHIYMTRNGRISMAGVTTGNVGYLANAIHEVTKSS
What is the function of this protein?
Amino acid aminotransferase important for the metabolism of amino acids and Krebs-cycle related organic acids.  No activity with D-Asp or D-Ala as amino donors.  In plants, it is involved in nitrogen metabolism and in aspects of carbon and energy metabolism.
What are the official names of this protein?
Aspartate aminotransferase, mitochondrial, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SYL_STRPZ
Sequence: MTFYDHTAIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTELYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTDKDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVADYKRQASLKSDLARTDLAKEKTGVWTGSYAINPVNGNEMPVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVEEAAFTEDGLHINSDFLDGLDKASAIAKMVEWLEAEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANVTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDKLFSDYAKGFVQLIAPFAPHLGEELWQALTASGESISYVPWPSYDKSKLVENDVEIVVQIKGKVKAKLVVAKDLSREELQEVALANEKVQAEIAGKDIIKVIAVPNKLVNIVIK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RXL7_STAA1
Sequence: MSKEKVARFNKQHFVVGLKETLKALKKDQVTSLIIAEDVEVYLMTRVLSQINQKNIPVSFFKSKHALGKHVGINVNATIVALIK
What are the official names of this protein?
Putative ribosomal protein L7Ae-like.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
Protein: RNJ2_STAAB
Sequence: MSLIKKKNKDIRIIPLGGVGEIAKNMYIVEVDDEMFMLDAGLMFPEDEMLGIDIVIPDISYVLENKDKLKGIFLTHGHEHAIGAVSYVLEQLDAPVYGSKLTIALIKENMKARNIDKKVRYYTVNNDSIMRFKNVNISFFNTTHSIPDSLGVCIHTSYGAIVYTGEFKFDQSLHGHYAPDIKRMAEIGEEGVFVLISDSTEAEKPGYNTPENVIEHHMYDAFAKVRGRLIVSCYASNFIRIQQVLNIASKLNRKVSFLGRSLESSFNIARKMGYFDIPKDLLIPITEVDNYPKNEVIIIATGMQGEPVEALSQMAQHKHKIMNIEEGDSVFLAITASANMEVIIANTLNELVRAGAHIIPNNKKIHASSHGCMEELKMMINIMKPEYFIPVQGEFKMQIAHAKLAAEAGVAPEKIFLVEKGDVINYNGKDMILNEKVNSGNILIDGIGIGDVGNIVLRDRHLLAEDGIFIAVVTLDPKNRRIAAGPEIQSRGFVYVRESEDLLREAEEKVREIVEAGLQEKRIEWSEIKQNMRDQISKLLFESTKRRPMIIPVISEI
What is the function of this protein?
An RNase that has 5'-3' exonuclease and possibly endoonuclease activity.  Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity).
What are the official names of this protein?
Ribonuclease J 2, RNase J2.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHFR_HUMAN
Sequence: MERPEEGKQSPPPQPWGRLLRLGAEEGEPHVLLRKREWTIGRRRGCDLSFPSNKLVSGDHCRIVVDEKSGQVTLEDTSTSGTVINKLKVVKKQTCPLQTGDVIYLVYRKNEPEHNVAYLYESLSEKQGMTQESFEANKENVFHGTKDTSGAGAGRGADPRVPPSSPATQVCFEEPQPSTSTSDLFPTASASSTEPSPAGRERSSSCGSGGGGISPKGSGPSVASDEVSSFASALPDRKTASFSSLEPQDQEDLEPVKKKMRGDGDLDLNGQLLVAQPRRNAQTVHEDVRAAAGKPDKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMERSSLCPTCRCPVERICKNHILNNLVEAYLIQHPDKSRSEEDVQSMDARNKITQDMLQPKVRRSFSDEEGSSEDLLELSDVDSESSDISQPYVVCRQCPEYRRQAAQPPHCPAPEGEPGAPQALGDAPSTSVSLTTAVQDYVCPLQGSHALCTCCFQPMPDRRAEREQDPRVAPQQCAVCLQPFCHLYWGCTRTGCYGCLAPFCELNLGDKCLDGVLNNNSYESDILKNYLATRGLTWKNMLTESLVALQRGVFLLSDYRVTGDTVLCYCCGLRSFRELTYQYRQNIPASELPVAVTSRPDCYWGRNCRTQVKAHHAMKFNHICEQTRFKN
What is the function of this protein?
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons.  Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus.  Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome.  Promotes the ubiquitination and subsequent degradation of AURKA and PLK1.  Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation.  May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer.  Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
What are the official names of this protein?
E3 ubiquitin-protein ligase CHFR, Checkpoint with forkhead and RING finger domains protein, RING finger protein 196, RING-type E3 ubiquitin transferase CHFR.
What is the protein family that this protein belongs to?
Belongs to the CHFR family.
Protein: SEPF_PROMT
Sequence: MSLISRLRAVVAGDDFLDSDFDELDYETSDDFENFNRGKKEGSTEMATISQANPFDGRSGFPPSNVIGMPGISTNDSEVSLMEPRSFDEMPRVIQALRERKTVILNLTMMEPDQAQRAVDFVAGGTFAIDGHQERVGESIFLFAPSCVTVTNSFQEEASPSNMSNKGNDLISKETSPAPEPAWGETVATAL
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RL31_RHOPB
Sequence: MKAEIHPNYHSITVVMTDGTEYVTRSTWGNEGDKLNLDIDSKSHPAWTGGQQQMLDRGGRVSRFQKKFSGFLKKD
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: DCR1C_PONAB
Sequence: MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRIKDIQSVYLDTTFCDPRFYQIPSREECLSGILELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSMEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYQETLHPEVFSMTVVSEKQPEKLRQTPGCCRAESMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWKVFFKRNDEITDERLENFPSSTEAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKVDYRPTIKENIPASLMEQNVICPKHTYSDLKSRDQDVTVVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLSDI
What is the function of this protein?
Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments.  V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs).  These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends.  These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively.  This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC.  The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint.  May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity).
What are the official names of this protein?
Protein artemis, DNA cross-link repair 1C protein.
What is the protein family that this protein belongs to?
Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECO_SYNP6
Sequence: MSRTYTTTAIVLKATPLGEADRLLTLLSPDQGLLRVVATGARKPRSKLGGRTALFVVGDCLIACGKSLDRLQQVETLTSHTALSGDLARLAAAQYLTELVLAQALERHPQPELFALLCRDLARIETQSGLEVLPYLLQSTWQLLAWAGWAPQTHYCCLTQQAVQPRLEQSRWRVRYSPSLGGVLADTAAYQRRPNQRELLLTATELAALQQIPTSQTVLPLASLPREAWQMLERALRHSAEYHLERPLQSALLLETLLTGSHVASV
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.