PharMolix/UniProtQA huggingface dataset:
Protein: HIS3_ALBFT
Sequence: MNWLDELKWDSQGLMPAIAQEQGSNDVLMLAWMNREALQKTAELGRAVYFSRSRNKLWFKGEESGHVQIVHEIRIDCDQDVILLKVTQTGHTPGIACHTGRHSCFYRVYENGEWKVTDPVLKDPQTIYK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRO_ADECT
Sequence: MAEGGSSEEELRAIVHNLGVSPFFLGTFDKRFPGFISSQRMACAIVNTAGRETGGVHWLAMAWNPRSKTFYMFDPFGFSDSKLKQVYSFEYEGLLRRSAIASSPDRCVTLAKSNETIQGPNSAACGLFCCMFLHAFVNWPDDPFDHNPTMGPLKSVPNYKLNDPTVQYVLWGNQEKLYKFLEKHSAYFRAHAAAIKARTAFNKLKQ
What is the function of this protein?
Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions.  Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors.  Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating.  Without maturation, the particle lacks infectivity and is unable to uncoat.  Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction.  Cleaves host cell cytoskeletal keratins K7 and K18.
What are the official names of this protein?
Protease, Adenain, Adenovirus protease, AVP, Adenovirus proteinase, Endoprotease.
What is the protein family that this protein belongs to?
Belongs to the peptidase C5 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Present in about 10 copies per virion.
Protein: KA126_LYCMC
Sequence: MKMKIFIITIVIALFITSIVEAQNKLDVKCVRLETCREPCKKQLCLLPMKCMNGKCVCSPSRKIC
What is the function of this protein?
Inhibits voltage-gated potassium channels.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 12.6.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 12 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: INS_AMICA
Sequence: AASQHLCGSHLVEALFLVCGESGFFYNPNKSGIVEQCCLKPCTIYEMEKYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PONJ_DICDI
Sequence: MRLLNNLILMVVLFVAVSNATTKFTFNTFSVRNTEDQTCFTKTAKTTDDSTKVDINKCTVGCGGSMKIRKGTKSQQYQFELFSSTDCTGETTSKVLFVCPNPSIDAISIKSTSNTIKCGTLPPDSEIKEDDTATAVVNDENNNETKNEPKTKTKSTPKSPSTPKTNNSNEDSDLTTSSSDSSSSTKSSPKSKSSTEVNENKPKSDNETAEGNNASSNIATFSLVIISLLVASLF
What is the function of this protein?
Binds F-actin and nucleates actin assembly.
What are the official names of this protein?
Ponticulin-like protein J.
What is the protein family that this protein belongs to?
Belongs to the ponticulin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: YSR2_CAEEL
Sequence: MRPSTASTPLSSSALNYLESFERNAKALRGNNNGSSTSGGNKKDESSTSKSIVSSPAPVKRRVSISDIISQARRQVSLSRTDSEDFDFLNESLKSSVFDESVSSDTDSEESHEEKRILPLGTPGQQVGRKSLKDIRELRNSIDQSLIKPPELKMLRSKAAGEESKRHAHFESIQEEEKISEDLPTAQLPSKSPFKKAIQSGSESSDSDSIIFDEVFEEVLPSPPRKPAPARTAPIVVEKKIEKPAVKEQKARKKKEKTPTPTESSFESSSDSSSTSESSTSSESSSSASESESESKSESQVSSSKTSTSKASSSKAYGSDFESEKSSSSSASTISKVTPKKLDKPQKTKKPDKKRAKPDDIRQNKKPEPIPYEDFIPKLSSRSSNSEKSTVRETNRTLEESLKKTLKINKSSEKMEKPRKDIRRAPRSSSSSSSTLRDAEREQDIERRREKRARRFRSRRRRSEEPHTCQENIHNMIESVIDTHVQMLDDFNRMEYAAVCEWTQVLRKFDGHDGPSSQKLREIIERRLNRKY
What are the official names of this protein?
Uncharacterized protein F59B10.2.
Protein: ZO3_MOUSE
Sequence: MEELTIWEQHTATLYKDPRRGFGIAVSGGHDRASGSVVVSDVVPGSPAEGRLRTGDHIVMVNGVSVENVTSAFAIQILKTCTKTANVTVKRPRRVQLPATKASPASGHQLSDQEEADHGRGYEGDSSSGSGRSWGERSRRSRAGRRGRVGSHGRRSSGGGSEANGLDLVSGYKRLPKQDVLMRPLKSVLVKRRNSEEFGVKLGSQIFIKHITESGLAARNHGLQEGDLILQINGVSSANLSLSDTRRLIEKSEGELTLLVLRDSGQFLVNIPPAVSDSDSSLMEDISDLTSELSQAPPSHVPPPPLKGQRSPEDSQTDSPVETPQPRRRERSVNSRAIAEPESPGESRYDIYRVPSRQSLEDRGYSPDTRVVSFPKGASIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDEILQVNGMPFRNLTREEAVQFLLGLPPGEDMELVTQSKTGHSLRRWSQSRVGDSFYIRTHFELEPSPPYGLGFTRGDVFHVVDTLYPGSGPGHGHSSHGGLWLAARMGRDLREQERGVIPNQSRAEQLASLEAAQRAAGVGPGASVGSNPRAEFWRLRSLRRGTKKASTQRSREDLSALTRQGHYPPYERVVLREASFKRPVVILGPVADIAMKKLTTEMPEEFEIAESMSRTDSPSKIIKLDTVRVIAERDKHALLDVTPSAIERLNYVQYYPIVIFCAPESRPALKALREWLAPASRRSSRRLYAQAQKLQKHSGHLFTATIPLHGTSDSWYQEVKAVIQQQQARPIWTAEDQLNSSSEDLDLTGHGLAASSGDLSCDSRTNSDYEDTDGEGAYTDREGGPQDVDEEVAPTALARSSEPVWVDDHQGLMGHGTTITDKWETQADSHYTQDQRRQDSMRTYKHEALRKKFTRARDVESSDDEGYDWGPATDL
What is the function of this protein?
Tjp1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:17000770).  The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells.  Binds and recruits PatJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (By similarity).  Promotes cell-cycle progression through the sequestration of cyclin D1 (Ccnd1) at tight junctions during mitosis which prevents Ccnd1 degradation during M-phase and enables S-phase transition (PubMed:21411630).  With Tjp1 and Tjp2, participates in the junctional retention and stability of the transcription factor DbpA, but is not involved in its shuttling to the nucleus (By similarity).  Contrary to Tjp2, Tjp3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (PubMed:17000770, PubMed:18172007).
What are the official names of this protein?
Tight junction protein ZO-3, Tight junction protein 3, Zona occludens protein 3, Zonula occludens protein 3.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Nucleus. Note=Exhibits predominant nuclear expression in proliferating cells but is exclusively junctionally expressed after confluence is reached (By similarity). Shows an epithelial-specific tight junction localization in a Tjp1/Tjp2- dependent fashion (PubMed:21411630).
Protein: KCNK5_HUMAN
Sequence: MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT
What is the function of this protein?
pH-dependent, outwardly rectifying potassium channel (PubMed:9812978).  Outward rectification is lost at high external K(+) concentrations (PubMed:9812978).
What are the official names of this protein?
Potassium channel subfamily K member 5, Acid-sensitive potassium channel protein TASK-2, TWIK-related acid-sensitive K(+) channel 2.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PSBD_ORYNI
Sequence: MTIALGRVTKEENDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFALIGFMLRQFELARSVQLRPYNAISFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSAIGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y4010_CHESB
Sequence: MGAEARLSRQRAYRKGHRGEWLAAFALRLKGYRILAHRFKTPLGEIDLIARRGDLVAIVEVKARPTLGEAMEAVSFTAQRRIDAAADLWLSRQPDYARLSLRYDLVAVLPRRWPVHVENIYAAR
What are the official names of this protein?
UPF0102 protein Meso_4010.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: Y2806_VIBCH
Sequence: MGRSFEVRKASMAKTQGAKIKVYSKYGKEIYVCAKNGGTDPDMNLSLRHLITKAKKDQVPAHVIEKALDKASGGAGEDYQPARYEGFGPGGASVIVDCLTDNGNRTYQDVRQCFVKTGAKIGTPGVVAHMFDHQAVFQFQGDDEEAILEALMMADAEVTDIEHEDGVITVFAPNTEFFKVKTALNEAFPDLTLDVEEITFVPQNRTVVSGEDAEKFQKFLDMLDDCDDVQQVYHNADIE
What are the official names of this protein?
Probable transcriptional regulatory protein VC_A0006.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC24C_HUMAN
Sequence: MNVNQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGTEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVTSMDVTETNVFFYPRLLPLTKSPVESTTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRAQRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317).  Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296).  May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317).  May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).
What are the official names of this protein?
Protein transport protein Sec24C, SEC24-related protein C.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
Protein: RSGA1_VIBVY
Sequence: MAKKKKLTQGQVRRVRDNQQKRLKKQADTIQWDEAMLGDSRRGLVITRFGQHADIEDAETGLIERCNLRRGIESLVSGDKVIWRKGLESMAGISGVVEAVEPRTSVLTRPDYYDGLKPVAANIDQMVIVSSVLPELSLNIIDRYLIAAETLGIEPLLVLNKIDLLQEAELATYREWLADYEKIGYKILYVSKRSGAGIAELEAQLQDRINIFVGQSGVGKSSLVNALIPELDIEEGEISELSGLGQHTTTAARLYHIPSGGNLIDSPGVREFGLWHLEPEEITKAYLEFRPYLGGCKFRDCKHADDPGCIIREAVENGEISEVRYDNYHRIIESMAENKANRQYSRNKKADL
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPRT_SHIFL
Sequence: MKTSRLPIAIQQAVMRRLREKLAQANLKLGRNYPEPKLSYTQRGTSAGTAWLESYEIRLNPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMESVLGVPARRTHQFELQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAIYRCVHCGEQLVAK
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_SHIBS
Sequence: MTEKKYIVALDQGTTSSRAVVMDHDANIISVSQREFEQIYPKPGWVEHDPMEIWATQSSTLVEVLAKADISSDQIAAIGITNQRETTIVWEKETGKPIYNAIVWQCRRTAEICEHLKRDGLEDYIRSNTGLVIDPYFSGTKVKWILDHVEGSRERARRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHTLDWDDKMLEVLDIPREMLPEVRRSSEVYGQTNIGGKGGTRIPISGIAGDQQAALFGQLCVKEGMAKNTYGTGCFMLMNTGEKAVKSENGLLTTIACGPTGEVNYALEGAVFMAGASIQWLRDEMKLINDAYDSEYFATKVQNTNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNANHIIRATLESIAYQTRDVLEAMQADSGIRLHALRVDGGAVANNFLMQFQSDILGTRVERPEVREVTALGAAYLAGLAVGFWQNLDELQEKAVIEREFRPGIETTERNYRYAGWKKAVKRAMAWEEHDE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: YIDC_COXB2
Sequence: MDIKRIILYVIVALLAIALFNAWQRDYPPTPKPTPTVEQPTANGDHPTAYTPPAFTPGAAEKTKKAGTIALTSKVSEARLITVRTDVLDVEIDTQGGNIVSAKLPKYPVSLEEKQTPVQILSGEPNELYVAQSGLTNGNGQPTTVQFESEKKQYVLENGQNQLIVQLTGRAPDGLLVTKTYTFHRDDYAIHLAYQVKNNTSKPWQGSLYTQITRRQPPTEHHHFYVRSYNGASMGSPQTPYEKLSYESLDKQNIDRTSQSGWIAMQQHYFLSAWVPGNPELTYHYYSHVIPASDEPNVYVVGFVSPQMNVAAGSEAATHATLYVGPEIAKRLKGLAPGLERTIDYGWLWPISMLLFWILSAVHAVFKNWGWSIIITTILIKIVFYWFSAKSFRSMARMREMQPRIQALKERHGDDRQALSRATMELYRKEKINPLGGCLPMLIQVPVFIAFYYVIIESVQLRQAPFIFWIHDLSVKDPYYILPIIMGLSMLAQQWLSPTSPDPTQQKMMWILPVIFTVFFINFPAGLVLYWITNNVVQTLQQWYVNKTYESHKAKLKARRARKRKR
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYR_BRUA1
Sequence: MNIFADFDARIKKTFQDIDLKPKDGGELDLSRIGVEPPRDASHGDIATNAAMVLSKAVGQNPRELAARIAEALKADEDVESVDVAGPGFINLRLKASYWQRELLVMLNEGTDFGRSRLGAGKKVNVEYVSANPTGPMHVGHCRGAVVGDVLANLLKFAGYDVVKEYYINDAGAQIDVLARSVMLRYREALGESIGEIPAGLYPGDYLVRVGQELAGEFGTKLLEMPEAEALAIVKDRTIDAMMAMIRADLDALNVHHDVFYSERKLHVDHARAIRNAINDLTLKGHVYKGKLPPPKGRLPEDWEDREQTLFRSTEVGDDIDRPLMKSDGSFTYFAGDVTYFKDKYDRGFNEMIYVLGADHGGYVKRLEAVARAVSDGKAKLTVLLCQLVKLFRNGEPVRMSKRAGEFITLRDVVDEVGRDPVRFMMLYRKNDAPLDFDFAKVTEQSKDNPVFYVQYASARCHSVFRQAADQLGLVDLDRVAMGSHFEKLTDESEIALVRKLAEYPRLIESAAIHQEPHRLAFYLYDLASSFHSQWNRGAENPDLRFIKVNDPDLSLARLGLVQVVSDVLTSGLTIIGADAPTEMR
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_LEPBL
Sequence: MAHKKGGGSSKNGRDSNSQRLGVKRFGGESVLAGNILVRQRGTKFRPGNNVGLGKDHTLFALVTGKVKFEMVTKLKMQVSVYPE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: LUFX_LUTLO
Sequence: MNSINFLSIVGLISFGFIVAVKCDGDEYFIGKYKEKDETLFFASYGLKRDPCQIVLGYKCSNNQTHFVLNFKTNKKSCISAIKLTSYPKINQNSDLTKNLYCQTGGIGTDNCKLVFKKRKRQIAANIEIYGIPAKKCSFKDRYIGADPLHVDSYGLPYQFDQEHGWNVERYNIFKDTRFSTEVFYHKNGLFNTQITYLAEEDSFSEAREITAKDIKKKFSIILPNEEYKRISFLDVYWFQETMRKKPKYPYIHYNGECSNENKTCELVFDTDELMTYALVKVFTNPESDGSRLKEEDLGRG
What is the function of this protein?
Sand fly salivary protein with antithrombotic, and anti-complement (alternative pathway) activities (PubMed:22796577, PubMed:28912782).  Is a slow, tight, non-competitive, and reversible inhibitor of factor Xa (FXa, F10) (PubMed:22796577).  Is specific for FXa (Kd=3. 86 nM) and does not interact with non-activated FX, or all other enzymes tested (PubMed:22796577).  In addition, it blocks prothrombinase and increases both prothrombin time and activated partial thromboplastin time (PubMed:22796577).  It also prevents protease-activated receptor 2 (F2RL1, PAR2) activation by FXa (PubMed:22796577).  In vivo, it abrogates edema formation triggered by injection of FXa in the paw of mice (PubMed:22796577).  Moreover, it prevents FeCl3-induced carotid artery thrombus formation and prolongs activated partial thromboplastin time ex vivo, implying that it works as an anticoagulant in vivo (PubMed:22796577).  It also inhibits the early steps of the alternative pathway of complement by direct binding to the proconvertase C3b-B complex, by inhibiting activation of factor B and consequently the formation of the C3 convertase (PubMed:28912782).
What are the official names of this protein?
Lufaxin, 32.4 kDa salivary protein, Lutzomyia longipalpis FXa inhibitor.
What are the subcellular locations of this protein?
Secreted.
Protein: UREG_PSEAE
Sequence: MTSQPLRVGIGGPVGSGKTALTLALCRELRERYNLAVVTNDIYTQEDAEFLVRNEALAPERIIGVETGGCPHTAIREDASINLEAVDQLNRRFPGLELILVESGGDNLSATFSPELSDLTLYVIDVSAGDKIPRKGGPGICKSDLLVINKIDLAPLVGASLDVMDRDARRMRGDKPFVFSNQKTGQGLDEIIAFIERQGLLTAA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_LACCB
Sequence: MQYPEPISKLIDSYMRLPGIGAKTATRLAFYTIDMNKDDVTAFAKSLVAAKEDLHYCSICGNITDEDPCAICRDKSRDQSTILVVEQPKDVMSIDRAQDYHGLYHVLHGVLSPIEGRGPEDLNIESLLKRLKANKAVKEVIIATNATPEGEATAQYLARLIKPAGIKVTRLAHGLSVGSDIEYADEMTLMKAVEGRTEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: HYCCI_MOUSE
Sequence: MFTSEIGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVTSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLRFTLQFLPELMWCYLAVSASRDVHSSGCIEALLLGVYNLEIVDKHGHSKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYRGVSSRIPISSGFMVQMLTGVYFAIYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGAMKSSKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGDTELTGQEELMDITEVDEGFYSRAASSTSQSGLSNSSHNCSNKTSVGKNQRRSGGSKAGAKERETAGESCRDHFARKQTQRAQSENLELLSLKRLTLTSSQSLPKPSSQGLAKTAATVFSKSFEQVSGAPVPRSPSPAIGCVAGADANRFSACSLQEEKLIYVSERTELAVKCQAGQQGPPSISVTLSAE
What is the function of this protein?
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.  The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis.  HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P.  Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system.  May also have a role in the beta-catenin/Lef signaling pathway.
What are the official names of this protein?
Hyccin, Down-regulated by CTNNB1 protein A.
What is the protein family that this protein belongs to?
Belongs to the Hyccin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex.
Protein: ATPF_MARPO
Sequence: MENGTYFIISSNFWTIAGSFGLNTNLLETNLINLGVVLGLLVYFGKGVLSNLLNNRKLTILNTIQDAEERYKEATDKLNQARTRLQQAKQKADDIRINGLSQMEKEKQDLINAADEDSKRLEDSKNATIRFEKQRAIEQVRQQVSRLALERALETLKSRLNSELHLRMIDYHIGLLRAMESTIE
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y8638_RHILO
Sequence: MSAYWIAVASAQHVRRGRNDGFMQVNHGKAAPLRRVKPGDGIVYYSPTTILGEKDGLQAFTAIGTVRYGKESPIKAKWAAASRRSGAMSNGRWLKKRRSSHCSTGWTSPLASRTGGITCASACSKSPITIFV
What are the official names of this protein?
UPF0310 protein msl8638.
What is the protein family that this protein belongs to?
Belongs to the UPF0310 family.
Protein: KBX11_LYCMC
Sequence: MQAKRTILLLLLLGMVALSSCGLREKHVQGLVNKFVPAGIVKNLLQAGIHKVAKMQYGCPIIKDYCSFHCNDLEKHEGYCHGTKCKCNIPNQYELF
What is the function of this protein?
Inhibits voltage-gated potassium channel.
What are the official names of this protein?
Neurotoxin beta-KTx 31.1.
What is the protein family that this protein belongs to?
Belongs to the long chain scorpion toxin family. Class 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CBRB_ECOHS
Sequence: MSVSRRVIHHGLYFAVLGPLIGVLFLVLYIFFAKEPLVLLVIIQVLPLFLLLSITTGAIPALLTGVMVACLPEKIGSQKNYRCLAGGIGGVVITEIYCAVIVHIKGMASSELFENILSGDSLVVRIIPALLAGVVMSRIITRLPGLDISCPETDSLS
What are the official names of this protein?
Inner membrane protein CbrB.
What is the protein family that this protein belongs to?
Belongs to the CbrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.