PharMolix/UniProtQA huggingface dataset:
Protein: COX1_GOMVA
Sequence: FFGHPEVYILILPGFGMISHIVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKWETPLLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIVA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS15_BRASO
Sequence: MSITAERKAEIIKANATKAGDTGSPEVQVAILSERINNLTGHFKTHGKDNHSRRGLLKLVSTRRSLLDYLKKNDEARYKALLEKHNIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: CH60_ECOLC
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVASKLADLRGQNEDQNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKNDAADLGAAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPH_EXIS2
Sequence: MRLDQRAQSDMRKIQLETDVNKHAEGSVLISVGDTRVLCTATVEEKVPPFLRGKRHGWINAEYAMLPRATAQRTGREAVRGKQTGRTMEIQRLISRALRSVVNLEKLGERTVWIDCDVLQADGGTRTAAITGGFLALVLAVDGLIQSGKLTDTPIKEGIAAVSVGKVGTELLLDLCYEEDAAADVDLNLVMTSSGKIVELQATGEEATFSRKEMLDMLELGEKGIEELLHAAEQSLGASWWYVGEEVEHK
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: ACE_HAEIX
Sequence: MKLLVVTILAGLAVCHGATKEEIVATEYLQNINKELAKHTNVETEVSWAYASNITDENERLRNEISAENAKFLKEVAKDIQKFNWRTYGSADVRRQFKSLSKTGYSALPAEDYAELLEVLSAMESNFAKVRVCDYKNSAKCDLSLDPEIEEIITKSRDPEELKYYWTQFYDKAGTPTRSNFEKYVELNTKSAKLNNFTDGAEVWLDEYEDATFEDQLEAIFEDIKPLYDQVHGYVRYRLNKFYGDEVVSKTGPLPMHLLGNMWAQQWSSIADIVSPFPEKPLVDVSDEMVAQGYTPLKMFQMGDDFFQSMGLKKLPQEFWDKSILEKPDDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQFFTVHHEMGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLERVGLLKNYVSDNEARINQLFLTALDKIVFLPFAFTMDKYRWALFRGQADKSEWNCAFWKLREEYSGIEPPVVRTEKDFDAPAKYHVSADVEYLRYLVSFIIQFQFYKSACITAGEYVPNQTEYPLDNCDIYGSKEAGKLFENMLSLGASKPWPDALEAFNGERTMTGKAIAEYFEPLRVWLEAVAVESLCHQRYKNVDL
What is the function of this protein?
Involved in the specific maturation or degradation of a number of bioactive peptides.
What are the official names of this protein?
Angiotensin-converting enzyme, Dipeptidyl carboxypeptidase I, Kininase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase M2 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: FOLD_HELAH
Sequence: MGMPNKGVVLLDGQALAYNIEEDLKYKIQAINTQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAQLLSLIKDYNNNQNISGVLVQLPLPRHIDSKMISEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDINFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDVDFTNAQKVASFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SYFA_SHESW
Sequence: MQQLTEIVEQALVIIDQASDLKALDDIRVDYLGKKGKITDMMKMMGSLSPEEKPAFGQAVNDAKQAIQQKLTERIDGLKSSELEAKLIAEKIDVTLPGRTQENGGLHPVTRTIERIETFFGELGFSVKQGPEIEDDFHNFDALNISEHHPARADHDTFYFNPKLMLRTQTSGVQIRTMETEKPPLRIISPGRVYRNDYDQTHTPMFHQVEGLLVDEHVNFAELKGILHDFLRNFFEEDLQVRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRSVGIDPEKYSGFAFGMGVERLTMLRYGVNDLRAFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FETUA_RABIT
Sequence: LVLLLSLAQLWSCHLVTAVPLLGYREHNCDDPEAEQVALLAVDHINNHLQQGYKHILNRIDKVKVWPRRPTGEVYELEIDTLETTCHALDPTPLANCSVRQVTQHAVEGDCDFHVLKQDGQFTVLSAKCDSTPDSAEDILKLCPDCPLLTPLNDTRVAQAAEAALTAFNEKNNGAYLQLVEIARAQLVPLPASTYVEFTVAATDCVAKEVTDPAKCNLLADKQYGFCKATVAEKVAREEVEVTCTIFPAQPVVPQPQPGVAGAAAVEPAPAVDPASPVSPPDGQSPSSLVVGPVLVAQAPAPPRAHYDLRQTFAGVPSMESGSGEAFHPGKVPVVVQPSVGAAPGPVITPCPGKVRYFKI
What is the function of this protein?
A cell adhesion protein that binds immature cells of the granulocyte lineage.
What are the official names of this protein?
Alpha-2-HS-glycoprotein, Fetuin-A, Haemonectin.
What is the protein family that this protein belongs to?
Belongs to the fetuin family.
What are the subcellular locations of this protein?
Secreted.
Protein: IF2_TRIEI
Sequence: MNNGKVRIYELSKELNLENKDILAVCQRLNISVKSHSSTITESEAELIRTTAENLPHSPSLSAAPEKSNSQNQDSGIGYNEQKKQQILEVRKPKPLLEKSQQKNHSKINNNLVTTPPNTSVLNNQVERVGISRPNSSLKSETLKDNSEVGDNSLVQHPNRPLNKDNTVKENYVPQKTDSNEKSKVEVPKLVAPPARPAPPSLNRNLRNTGVNKPNQKNKKPKQEGKKRKDKEEKPFEKPAIVSKKENKDTSIEKPTIASKKENKDTFQNRESVKTSASDTSSQLKPKHREKPTVKLKQEQKPQLAPKPKLTTPLKEESTDVNLGLDLEGKEPEDNVAETVSYDLEKPRRKTIAPSKPTLTKDKKVSKWEEEEEDTSEVIQKNAKSSAKNKRLRLKPLLEDEDEELAELLNKPAPVTMSLSLARPAKPKSFTEKNKPQPGSNISNLKKKSSQSHESVQSESNEQTQSAELKPVEKLVISASMTVQELALALAIPETEIIRRLFMKGIAVNITESLDIPTIEMVVKEEGIPIEVPEEQSAAKKTTEILEETDLASLQRRPPVVTIMGHVDHGKTSLLDSIRATKVAAGEAGGITQHIGAYHVDVEHEGQMQQVVFLDTPGHEAFTAMRARGARVTDVAVLVVAADDGVQPQTIEAISHAKAAEVPLIVAINKIDKEEANPDRVKQELMEHGLVPEEWGGDAIMVPVSAIQKQNLDTLLEMILLVSEVEDLQANPERLAKGTVIEANLDKARGPVATLLVQNGTLKVGDIIVAGSVYGKVRAMIDDRGYRVDKASPSFAVEVLGLRDVPQAGDEFKVFKNEKEASAITTERADAKRESRIMRRTSLGAVSVRAQEGELKELNLILKGDVQGSIEAIVAALRQLPQKEVQLRLLLSGAGEVTETDIDLAAASEAVIIGFNTTMASGARQAADAAGVDVREYNVIYKLLDDIQGAMEGLLDPELIEEPLGQVEVRAVFTINRGAVAGCYVLSGKVVRNCKVRVRRNGEIVYQGILDSLRRMKDDVKEVNAGYECGVSFDNFNNWSEGDIIEAYQMVTKRRKLST
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRB_ECODH
Sequence: MANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKYDSGCGWPSFYEPVSEESIRYIKDLSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLRFTDGENGEEING
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: COAE_CUPPJ
Sequence: MLEIGLTGGIGSGKTRVADMFAARGAAIIDTDLLAHEITAPGGQAIPALVEAFGPQCLRPDGAMDRDAMRAVVFADPAAKARLEGITHPLIRELTTSRAAEIAHAGEHPYLIYVVPLLVESGAWLNRVGRVLVVDCSEDTQIARVMSRNGFSREQVLAIMAKQATRAQRLAVAHDVIDNDGPVEALTAQVDQLDRTYRALSAAGVTQA
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GBB_NICPL
Sequence: MSVTELKERHMAATQTVNDLREKLKQKRLQLLDTDVSGYARSQGKTPVTFGPTDLVCCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPSGHSVACGGLDSVCSIFNLNSPIDKDGNHPVSRMLSGHKGYVSSCQYVPDEDTHLITSSGDQTCVLWDITTGLRTSVFGGEFQFGHTADVQSVSISSSNPRLFVSGSCDTTARLWDTRVASRAQRTFYCHEGDVNTVKFFPDGNRFGTGSEDGTCRLFDIRTGHQLQVYYQPHGDGDIPHVTSMAFSISGRLLFVRYSNGDCYVWDTLLAKVVLNLGAVQNSHEGXISCLGLSADGXXLCTGSWDTNLKIWAFGGHRSVI
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta, NpGPB1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family.
What are the subcellular locations of this protein?
Cell membrane. Endoplasmic reticulum membrane.
Protein: LIPB_RHORT
Sequence: MEWRFADTPVSYPEALAFMDDRIAKIREDRAGECVWLLEHPPLYTAGTSADPADLLSPDRFPVYAAGRGGQYTYHGPGQRVGYVMLDLRRRGKDVRCFVHNLEELMIRALAEFNIRGERREGRVGIWVARGGGREDKIGAIGVRVRHWITFHGFALNVEPDLSHFSGIVPCGISDHGVTSLWDLGQTATLQEVDSALMRSFDAVFGPCPTESLTST
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YUTK_BACSU
Sequence: MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGYIVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFSALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAGLTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETEKTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGGAFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGSHIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLANLLSAAIAGMFI
What are the official names of this protein?
Uncharacterized transporter YutK.
What is the protein family that this protein belongs to?
Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YKE44_YEAST
Sequence: MGYVIMTFSSARMSERRARIIYIWMHLSAYKINFPFVQFPTFFSLFRLQKKAAILIKNPSPFFLFFLFPYRKNSTARTIHQINQAVALVLLCVSHHLTYLPSVPSL
What are the official names of this protein?
Uncharacterized protein YKL044W.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: EIF3J_DROPE
Sequence: MADDWESAADSEIILQNAASTVNKWEGEDDDDDVKESWEDEEEKKDEENEKPTITDVPVKTKPSKALKAKLEEQARLEEEKEAKRLASLTPEEKLAEKLRLQKIQEDSDLNHALDTFGVTRAETNGNGLDSFNPETKEQFKEFGSALSWKVGQYRESAEFPQFVEDLVRGLCIHLSAADIKKVKMSVEILHSEKLKMEKAIAKKAAGKNKGKATLRTESDDIDDYKKYGNDFSEDYDDFM
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit J, eIF3j.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit J family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SKH1_SCHPO
Sequence: MSKKPVLNLDTSNGFSEEYISHPERNDNQGIVEITDLVFSSESKLTQRKESRDSKTFVPSFLEELDDDHLHELVTNGGILYMNSLGEGVSGSVRKCRIRGTQMIFAMKTVLAAPNTALQKQLLRELKINRSCTSPYIVKYYGACYNNAECQLNIAMEYCGAGSLDAIYKRVRSQGGRTGERPLGKIAFGVLSGLSYLHDRKIIHRDIKPSNILLTSKGQVKLCDFGVSGELVNSLAGTFTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNRFPFPPEGSPPPMPIELLSYIINMPPPLLPQEPGIKWSKSFQHFLCVCLDKDKTRRPGPQKMLTHPWVKAFERIHVDMEEFLRQVWSD
What is the function of this protein?
Involved in the mkh1 signal transduction pathway that plays a role in cell wall integrity.  Activates spm1/pmk1 via phosphorylation.
What are the official names of this protein?
MAP kinase kinase skh1/pek1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Protein: FSAB_ECOL6
Sequence: MELYLDTANVAEVERLARIFPIAGVTTNPSIIAASKESIWEVLPRLQKAIGDEGILFAQTMSRDAQGMVKEAKHLRDAIPGIVVKIPVTSEGLAAIKMLKKEGITTLGTAVYSAAQGLLAALAGAKYVAPYVNRVDAQGGDGIRTVQELQALLEMHAPESMVLAASFKTPRQALDCLLAGCESITLPLDVAQQMLNTPAVESAIEKFEHDWNAAFGTTHL
What is the function of this protein?
Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction.
What are the official names of this protein?
Fructose-6-phosphate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_SHEPA
Sequence: MINLFLFCRAGYEKDCAAEIQVRAAELDIGGFVKTNTNDAYVIFQCFQAGDAEVLAKNISLDSLIFARQMFAAKELLKGLPEQDRISPIVEALTQVNKAGELRVETPDTNEAKERSNFCRKFTVPLRQALKKSGALLEKENPKRPIIHVCFVASGQAYVGYSLSNNSSPYFMGIPRLKIAADAPSRSTLKLDEAFIHFIPKEEQETRLSSGMKAVDLGACPGGWTYQLVRRGMFVAAVDNGPMDQGLMDTGQVKHYQADGFRFEPPRKNITWLVCDMIEKPSRVAELIEAWAINGWFKESIFNLKLPMKARYKEVSTILATMEEILKENGVDDFSIAAKHLYHDRDEVTVHLCLRPSQPW
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y301_CHLTE
Sequence: MNITTDSLQQAWHRLDAPGSYEWWYFDAEDESEGISVVFIWFVGFAFSPYYLSHYEEWKAHRRDDQPYPLDYGGFSFQLYQDGRETINFIKEGGRELFASEDGGIGVRFEGNRFVYDPLRDEYRLSIDFSFPARDRSVQASFSFRPLHRFDYHFDTDLHAGVDFRHQWVLSVPKAEVHGLLDITSLSSDKRQVLQFRGRGYHDHNLGTVPMYESIDRWYWGRTFSRRCDLIYYVVFLRGCSAEPQAVLMLLDHKTGRQSTFDAVRVSESRFTRGLFAPVHGKTLRLEAEGVSVEVQHQKALDTGPFYLRYTSLLSMMIGEEAQEEVRGISEFLNPAPLKSRLMQFFTASRVWRAGKQSAMYVLYNFFKHRFERVHRINRKKF
What are the official names of this protein?
Hydroxyneurosporene dehydrogenase, Hydroxyneurosporene synthase.
What is the protein family that this protein belongs to?
Belongs to the CrtC hydratase family.
Protein: SYS_ECOSE
Sequence: MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEVPLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGLR_PENJA
Sequence: MPSYLRNLVWATLAAGLVSAAPTPSRVSDLTKKSSSTCTFSSAASASASKSSCSTIVLSNIEVPAGKTLDLTDLKDGTKVIFEGTTTFGYKEWSGPLIKISGSDITVEAADGAVINADGSRWWDGEGTNGGKTKPKFFYAHSLDDSTISGLNIKNTPVQAFSIQSDNLIIDGVTIDNSDGDENGGHNTDGFDISESTGVTIRNAVVKNQDDCIAINSGQNIYFTGGTCSGGHGLSIGSVGGRDDNTVKNVTITDSTVTDSANGVRIKTVYDATGSVSDVTFSDITVSGITDYGIVIEQDYENGSPTGTPTSGVPITDLTVKGITGSVESDAVEVYILCGDDACSDWTWSGVDITSGQTSSKCENVPSGASC
What are the official names of this protein?
Polygalacturonase, PG, Pectinase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KHSE_ECOSM
Sequence: MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPETAQRVADWLGKNYLQNQEGFVHICQLDTAGARVLEN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRE2_MAIZE
Sequence: MSAALAVTDEVALPIRAVGDLAAAAEVSREEVAVITQCAALGGKLPFEDASVGAVLAVIKNVESLREQLVAEIRRVLKAGGRVLVQSPAPSSSQKPNTDIERKLLMGGFAEVQSSAASSQDSVQSVTVKAKKASWSMGSSFPLKKTTKALPKIQIDDDSDLIDEDSLLTEEDLKKPQLPVVGDCEVGAAKKACKNCTCGRAEAEEKVGKLELTAEQINNPQSACGSCGLGDAFRCGTCPYRGLPPFKPGEKVSLSGNFLAADI
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.  Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase.  Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
What are the official names of this protein?
Anamorsin homolog, Fe-S cluster assembly protein DRE2 homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: SUMO1_DANRE
Sequence: MSDTETKPSSDGGEKKDGEYIKLKVIGQDNSEIHFKVKMTTHLKKLKESYSQRQGVPVNSLRFLFEGQRITDNLTPKELGMEDEDVIEVYQEQTGGCRND
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
What are the official names of this protein?
Small ubiquitin-related modifier 1, SUMO-1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane. Nucleus.
Protein: SRY_BALBN
Sequence: MFRIVNGEDYSPAVQQRNSLDFGKAPSLLWTDNGGSNDRCETGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKRPQKLLPADSSVLCSRMHIEETLYPFTYKDGCAKATRSRMESRLSYSQPTNTTSSLLPQEHRSSWTSLSHNRVT
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: SC61G_MOUSE
Sequence: MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG
What is the function of this protein?
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER).  Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity).  The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity).  The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).
What are the official names of this protein?
Protein transport protein Sec61 subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.