Protein: MLFA_ASPNB
Sequence: MSRFSCIFPTLTDGYVSNPDHTRAAGRRTYTIDLSGWKAPGSETEAHILAAWGLVLSSYVGTDEVAFYVVPTTGPDTTALADLKVEGDMSRQSLTYAAEQLLHPGLVGAGQVSGETANTIITFAKDIESLFVTQTEAANVGTAMAQALAEVGTCDNDRLIKDLNLMSPAHLEHIWRFNANVPGIWEESFHDVIERHATNRPHSPAVDAWDTKLTYADLVREARLLAAYLQQRGVGPGSVVPISFERSGAALVAMLAVSKAGGAFVSVPPNLPAGRLDAILDVIEAPFVVTWTRYESFWAERLPTLPIDNYPKPAADTTVEALGKPEDLFYVIFTSGSTGRPKGCMLSHSNWLNGALRNAPSWKYGPESRVLQMLSHTFDMSLLEICTSLGSGACVNHVIMTPSLARALRPDDVPELKTMCLGGEAFPKEIVTMWSERINLWQFYGPSECSINSSSRPITRPDADPLNIGPPNSAACWVADVHNYNKLVPVGAIGELLVSGPIVGMGYMKNPVKTAEAFLEEVGFVAKDDPQFGGFRFYRTGDLVRWNSDGTITFCGRADTQVKLNGQRLELAEVEYQLGLESGVQYAIAMAPQAGLCKNNLIAILTVKGTSTGNQDTAADEIPLLDRRDPIVQETVKKLRSQLQHALPRYMVPTIWAFVGRMPMSASGKIDRVQLRDWVQKMNQETFDAITGRSLEAEDHVLGLSRLEQEVQLAWAEALSLSAAEVGLQQPFVALGGDSIKALDAVARCRARQIKISMVHTLSCEGVREAASLAEVQETPAQQVAEMAVDYSNLWTRLSDDYDLDKLGVTQLEEVEDVFPCTTMQEGMFLGQIRRPGAYHMRFFHRVQLKGGCLPTVERIQQAWASLVERHPSLRTVFVDDLSPEAIYHSIVLRSVPMELRMREVPRDLRAEAALAMFTEELVPFRANAPLHRMLLLTCRGRVPYFMLEISHVIMDGYALSVFRREFIRACSSSAPLPRGPDYRMFANYHRTRQTDDSARYWTNYLADCVPCHIPTHAVSAPSDAPPEWPRTLQRRDFGFENSAAFLQRCKERQVTLACAIRAAWALVLRAYTQSEDVCFGYVSSGRNVPVPEVETIFGLCLSMQVCRARLSEASTIASLARKIQEDYAASLPFQHYPLAEAQRGLKQTHGQGLFNTAISMEWVPPSVEDEDALLDLEEICEQDDPTEYDIAISVDVHEGHIKLGFLYWPNLTDFEITHLAEALRGAMNRFAFQPDEALNTLSLLQASDVCSALADGPTLLPLEAVRGNVVSMIDRWVTRQPEGAAIDGWDGSLSYKELHEQSSWVARNLLHQGVQLGDRVLVSCEPDACWCSRTRRTQRSASNGWQKKCNAALIVADPTYEERFATAGARVLSTTTVCAPAAWDYEFPSLDEHDLVSILFTSGSTGTPKGILMEHGALATSVLLGHGRTLRFSRYTRMLHFASLTFDAALAEMFTTLAHGGCICVPCEDDRLSDVSGCISRFAVNTAMLTPSVGRLLDPGALLTLKTLIMVGEPMSRLDVERFAPVLDLYNGAGPTETSIMVTIAGPMEPTDEPVNLGYAVAGVRLWVTEAENPNRLAPLGAVGELIVEGRLVTRGYLDGPARTQEAFLPSLPWLPSQHALYRTGDLVRYADDGSLRYMGRKDTQVKLRGQRIELQEVEYHLRKSLQQAQIVVEMVVPAGKMRAQASLVAFVSGLTAEDVESSSACNLEGTILISQIVLPKSAFQALEEVLPRHMIPSVYNALDTIPLSVNGKADRRRLLPPIRTPLKESKSVKWTPASELERTLLELWAATLGLEAETIHGDDSFFELGGDFVSAMKLVATARDKFKLSLSVPQMFRYPTICHLAAEVGEPAGQSASSASSTTEEGFTFSTPDDSSTNDGVDDDFLELVTAQLAQLAQEKGKKVDIAALLKQLQGGSSSNKTPSVSSSSSSSSSSKRKKNAAKAESLAEAAAPIPVQFSLLDGGADALDKVRAQAVEHCKITHEDIEDIYPATALQEGMMALTARTPGVYTTSLTGNLSELVDLAWLQYAWGKAAEAHPILRTRIILTDNNTAVQVVQRAKGLPWDTYSLREDDVLPDLTSNMTSGSPLLRLALVHRQNQPRMLLVAIHHALYDGWSMPLLKQAVEDAYHGRDLRSQPFTPFIKHLIAGKPAAQDFWTTHLDSFVGGIFPKLPSIYHQIQPTKRRTRPMTLPTAAPKAQYTMATKIQAAWAVTVPRYAEVNDIVFGTVSTGRSAPVPAIDRMVGPTITTVPVRISLGDQADRVLSLLQRVQEDSWNKLDHEHLGLQHIRHLGESAAAACSFQTLLVILPREQPDTKYRSTLLSGLQDVAELEGVDTYPLMLVCEPDSARLHLTAVFDRAVLDGATLDRMLAHWELVLTQMWNEPDMAVIEIDAVSCSDKETLMRWNTGETIPDGCAHDAVCEWSRRTPHAPAVCAWDGDWTYEELERCSSLVASQIFAHGLSSGDFVALYHEKSRWTAAGILALFKAGAILITLDPAHPTDRIKDILDQARPRLILTSQSLLDVARNLETPVLSVQLAASQPLPEGWSSLPTISPTLAAYAPFTSGSTGRPKGIPLDHRGLAASTASIARSCLLRPASRVLHFASFAFDASMMEQLIAWHAGGCLCIPDETARQTDLAKCIRDFNVTWAFLAPSCLRLITPDDVPSLQALGLGGESMTSEDITIWSPRLRQIIQLYGPAECCIVAALTEVTKPSENRLIGRPNACRCWVVDPQNPDRLAPIGAVGELLIEGITVGRGYINDPDRTTPAFIRPPKWLQTLYPDDQEPKRLYRTGDLVRYAGVDGKLAFIGRRDGQLKLHGQRTELADVEAHLRSLIPGMQKMVVEMVHSADNQSPFLAAFLEEISTSQKPKEREIGLLHLSQSQCALDVKAIDSALSRTVPQYMIPSMYLHISRLPLSASGKLDRRHLREMVAELPHQRINEYAAGSGLSVPDRPVTSQEREMQAIWARVLSLDPNTIGVNDDFFRIGGDSISGMQVSTKCNAAGIHITSADLFRHRTIEQLICHINTIRTTDCASVSLPTEPVDEWVALAPIQQLFFEVAPEGPNHFNQSLLLRTSRRVGVEELAGGLDILIGRYSMLRARFCRKDSGQWFQQVKSLDSEPVSAFYRLAAHNQITRESLPTLFTAAQMALSIEDGPLLTVDLVELKDGSQLVYLAAHHLIIDLVSWRILHGDLEEYLQTGSLSSATGSVPFLTWTQLQAEYSAEHLTPARALPGFQEANDDFDVMRYWGISSESNTFGQTSTSRFTLDRTVTDILFGSANKVMDTRPVEILQAALWYSCNQALTDHPGPRIYVEGHGREPWTDSIDVSGTVGWFTIMSPLVSTPWHHLSRKSMRDFVDVLSYIKDQRRRIPANGWAYFTSHYLNDEGRVAYGRTKPVMEVLFNYMGQYQEMKREDAMLQLAGDDVQSGTGASDIADNVPRFSLIDVTAFTANGCLTFEFTFPQLIQQDARLEHCIKESFDGPTCPRRLEYLPLLSRATGHVVGAAARSAGISATIQVSGYVSRANRPTFIGKVSDHSHFDQVVMVPGSLQHLVRGDAMDANPTEGLPHTINITSDSTGAIICEWNVSHALVDAMSIAVIQREVNQALEGSLGQHQNLPQYVEYIEWLTLQDNTEAQAYWQKYLDGVEPCLFPKLTSSPDKVNPEATIAAIRATWSRDARMDELCHKHAITLTNLFHIVWAIVLGAYVGTDEVCFGYTALGRDVPVHRVETMVGPLVNVLATTVRHEENETILNALLTHQAHLTNSLQHQHYALADVYAALGLVGSQLFNAIVSLQDTSHFDAPDEQRTRLEMLPANDVSEYDVALNIGVDKSSIQLVRSYQTVSLSAEQADALLRTAFHVLDEILRDPTQRFCELEVISPKCKEQLVKWNAGMLAPTDEYIHEKIQGQCRIHNSRQAVCAWDGIFTYAEVDDLSSRLAARLIRMGVTSEDIIPIYSPKSRWTVIAILGVLKAGAAFTLLETSHPMARLHVICNQIKAPMIIAPASHAIPAANLAPILVVLDKIMSLAQERPVPLPAVGIPPAREALAYLIFTSGSTGNPKVVMVTHQNLCSNASIITTSVNMTSDSRVLQFASHAFDACILGLLGALIAGACLIIPSESENKEDLAGCMERMDVTWALLTPSVARILKPETLPRLLNLVLGGEPIAASDLDMWRGHVQVVCAYGPTETTIVASTTSPSTFPMDGKNIGVPSGSSLWVVSRQNYQKLAPLGATGELLIEGPNVSLGYLGDPGKANKAFPDSPIWLSQLRKSPTRVYRTGDLVRFDTTTGTIRFVGRKDNQIKFHGQRIELGEIEHHAQLAFSSASMVIVDLITPEQPQQPYIVAFVHQSDAANETTDTNDTLLLPPSEAFRADALAAQNKMYERLPHYMVPAVFLPLHRLPLSVTGKADRKRLRQCALALSSPELSAYRATASRKRMPSTAAERKMQGLVATVLGRDPTEIGMDDSFFYLGGDSVQAMRLVAEGRQQGLTLSLRAIFDSPCLGDLSDQAKSLIEDNQRASTASRGNLRYDCDQIDKIVATKSLNKTDVVDVLPTTSFQHHWLDAQLKSYIVADISGPIDPARLLRAMHRVVEAHPILRVSFVPYENTTMQVILNKAVAIKSADPSNTTVEEICRQDADTPTVPGMPYLRVILATQVEADHTLILRLSHAQYDAVSLSLLMNDLGHAYANETHPLPSSHFPRFNDYTTYQQAQRADPTAITFWRHLLQDVSLTYLNLQPAESSASNGTPITLSRDIDIAIFPSLPSDITIATTVKAAWSLVLAQKTNSPAVIFGQVVHGRAIALPGVEGIIGPCANITPVVARLGLQTTGLELMQTLQDQHRSAMPYETVDLDDALAYAKDSQAGRKGLQTIVQHQNNVMVDDMELSLGEVKCGVDVRAVDHLPKEVWVYSSVDEKRPGMLEVKIMSSTLVLGEEVAEELMGLLVEKIVGLLRHPESVCF
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of malformins, cyclic pentapeptides with a disulfide bond between 2 consecutive cysteins, that show potential anti-tumor as well as antimalarial and antitrypanosomal properties (PubMed:30560908).  The nonribosomal peptide synthetase mlfA is responsible of the formation of the cyclic pentapeptide (Probable).  The malformin biosynthesis clusters in malformin-producing fungi also contain enzymes involved in the formation of the disulfide bond between the two consecutive cysteins within malformins, in addition to additionnal tailoring enzymes such as methyltransferases or oxidoreductases.  They are also composed of up to 4 major facilitator superfamily transporters, and transcription factors probably involved in the regulation of the expression of those clusters (Probable).
What are the official names of this protein?
Malformin synthetase mlfA, Malformin biosynthesis cluster protein A, Nonribosomal peptide synthetase mlfA.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.