PharMolix/UniProtQA huggingface dataset:
Protein: SPB10_CHICK
Sequence: MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPVE
What is the function of this protein?
DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells.  Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization.  Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases.
What are the official names of this protein?
Heterochromatin-associated protein MENT, Myeloid and erythroid nuclear termination stage-specific protein, Serpin B10.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Ov-serpin subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin.
Protein: GLYA_MICAN
Sequence: MTDTNLDILSLTDPAIAGILQKELQRQRDHLELIASENFTSAAVMAAQGSVLTNKYAEGLPKKRYYGGCEYIDEAEQLAIDRVKRLFGANHANVQPHSGAQANFAVFLTLLQPGDTIMGMDLSHGGHLTHGSPVNVSGKWFRVVQYGVSPESERLDYDLILDIARKEKPKLIICGYSAYSRQIDFEKFRAIADEVGAYLMADIAHIAGLVATGHHPNPLPHCDVVTTTTHKTLRGPRGGLIMTKDEELGKKFDKSVFPGTQGGPLEHVVAAKAVAFGEALKPEFKIYSGQVIANAQALAGQLKARGIKIVTDGTDNHLMLLDLRSVGMTGKEADRLVSTINITANKNTVPFDPESPFVTSGLRLGSPAMTTRGLGETEFIEIGNIIADILLNPGDEALRTACRQRVAKLCESFPLYPHLHISVPALA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCL4_CHICK
Sequence: MKVSVAALAVLLIAICYQTSAAPVGSDPPTSCCFTYISRQLPFSFVADYYETNSQCPHAGVVFITRKGREVCANPENDWVQDYMNKLELN
What is the function of this protein?
Monokine with inflammatory and chemokinetic properties.
What are the official names of this protein?
C-C motif chemokine 4 homolog, Macrophage inflammatory protein 1-beta homolog, MIP-1-beta, Small-inducible cytokine A4 homolog.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS9_PSE14
Sequence: MSATQNYGTGRRKTATARVFLRPGTGNISINNRSLDNFFGRETARMVVRQPLELTETVEKFDIYVTVIGGGVSGQAGAIRHGITRALMQYDETLRGALRKAGFVTRDAREVERKKVGLRKARKRPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: YCJV_ECOLI
Sequence: MAQLSLQHIQKIYDNQVHVVKDFNLEIADKEFIVFVGPSGCGKSTTLRMIAGLEEISGGDLLIDGKRMNDVPAKARNIAMVFQNYALYPHMTVYDNMAFGLKMQKIAKEVIDERVNWAAQILGLREYLKRKPGALSGGQRQRVALGRAIVREAGVFLMDEPLSNLDAKLRVQMRAEISKLHQKLNTTMIYVTHDQTEAMTMATRIVIMKDGIVQQVGAPKTVYNQPANMFVSGFIGSPAMNFIRGTIDGDKFVTETLKLTIPEEKLAVLKTQESLHKPIVMGIRPEDIHPDAQEENNISAKISVAELTGAEFMLYTTVGGHELVVRAGALNDYHAGENITIHFDMTKCHFFDAETEIAIR
What are the official names of this protein?
Putative uncharacterized ABC transporter ATP-binding protein YcjV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: KR194_HUMAN
Sequence: MSYYGSYYRGLGYGCGGFGGLGYGYGCGCGSFRRLGYGCGFGGNGYGYCRPSCYGGYGFSILLKSYPEDTISEVIRRSFNLTKY
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 19-4.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 19 family.
Protein: NGLY1_DANRE
Sequence: MPGSQGVLALCENTTEVFLDVSKLLITYADNILRNPNEEKYRSIRIGNPTFSTKLLPVKGAVECLFEMGFEEAETHLVFPRSASVEKLRQVRETIAAERDQRLGASNTASSPQNASVPPVPAPPPSLSSTASAGPAAAAVPTPAPASIPFTSSSATFQRTVQSNFQHVLVYEDPELQQKALECIPHELLRSRAKERLKQANDADAACSLGEEDMLVLDLLQWFKSDFFSWVDNLPCIQCGGKTQPSGSLSPSSDDLHWDAGRVENHFCHTCQLSTRFPRYNNPEKLLETRKGRCGEWANCFTLLCRALGLEARYIWDSTDHVWTEVYSQSQRRWIHCDPCENACDKPLLYEVGWGKKLSYILAFSKDQVADVTWRYSCKHPEVLSRRTQVQETWLLHMLNKLNAERQQFLGAERKQQLLQRLLVELVEFISPKSPQPGELGGRMSGSLAWRAARGETGASNAKEDTQENVFTPSESEKESKRFHICYNVTKDCYYRVSNGQETIQGWQKGAWRTENMFRKEEHDWQMVYLARTEGASFGRMSWKFNCAPAGMKMKSASVRVFSQTFHSGTVRWSLSTNETTTEFPGDGELHSFSNVSGGTELIVEAELTGGDGSTSWQHAQLFRQSLKDTEKVLFEVMVEMEKS
What is the function of this protein?
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation.  Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp.  Prefers proteins containing high-mannose over those bearing complex type oligosaccharides.  Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins.  Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity).
What are the official names of this protein?
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, PNGase, N-glycanase 1, Peptide:N-glycanase.
What is the protein family that this protein belongs to?
Belongs to the transglutaminase-like superfamily. PNGase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGR2_METKA
Sequence: MEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIGVPKQCAEGISAHGLEHAGIEPQDEWIATEISRALIYAPNGKEFEVPGDGYVLERRVFDKWLVVRAVEAGAEVELLAHARRALLDEGRVVGVEYEGEDGVHEVRARIVIAADGIESRIGRTAGLVPSLKPVEMCTCAQYEMVGVDVEEDATHFFVDAEFFPGGYFWIFPKGEGRANVGLGIRGSESEPGDALKVLNRALEDHELISEAVADAVPVEVNVGGVPVCGPVERTYGDGILLVGDAARQVNPLTGGGLHTSLVCGRIAGEVAAEAIEEDDTSASFLKRYQDRWEEEFGKTFKYALKASKIFSEMSNEELNALAEALDREDILRLVKGEEVVKVAKKVISRKPSLLKYAKHLMK
What is the function of this protein?
Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids.  Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
What are the official names of this protein?
Digeranylgeranylglycerophospholipid reductase 2, DGGGPL reductase 2, 2,3-bis-O-geranylgeranylglyceryl phosphate reductase 2, Geranylgeranyl reductase 2, GGR 2.
What is the protein family that this protein belongs to?
Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
Protein: PUR5_HAEI8
Sequence: MSNTQLSYKDAGVDIHTGNELVERIKGDVKRTRRSEVMGGLGGFGALCALPTKYKEPILVSGTDGVGTKLRLAIDLKKHDTIGQDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAASVIKGIADGCEMSGCALVGGETTEMPGMYHEGDYDLAGFCVGVVEKSEIIDGTAVKTGDTLIALGSSGAHSNGYSLIRKVLEVSGANPADLLEGKPLSEHFLAPTKIYVKSILQLIKQTEVHAIAHLTGGGFWENIPRVLPANTKAVIDESSWQWPAIFNWLQEKGNISRYEMYRTFNCGVGMVISLPEKEVETALALLEQAGEKAWVIGKIEHLGEGEAQVEIQ
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP5D_CHLTH
Sequence: MHTLVFCSFKGGTGKTTLSLNVGCNLAQFLGKKVLLADLDPQSNLSSGLGASVRSNQKGLHDIVYTSNDLKSIICETKKDSVDLIPASFLSEQFRELDIHRGPSNNLKLFLNEYCAPFYDICIIDTPPSLGGLTKEAFVAGDKLIACLTPEPFSILGLQKIREFLSSVGKPEEEHILGIALSFWDDRNSTNQMYIDIIESIYKNKLFSTKIRRDISLSRSLLKEDSVANVYPNSRAAEDILKLTHEIANILHIEYERDYSQRTT
What is the function of this protein?
Required for growth within mammalian cells.
What are the official names of this protein?
Virulence plasmid ParA family protein pGP5-D, Protein P-9.
What is the protein family that this protein belongs to?
Belongs to the ParA family.
Protein: ACHB3_HUMAN
Sequence: MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPALKMWLHSYH
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit beta-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: CLPX_SHEHH
Sequence: MGEDKGNGDGGKLLYCSFCGKSQHEVRKLIAGPSVYVCDECVELCNDIIREEIKEISPKQDQDKLPTPHELRAHLDDYVIGQDKAKKVLAVAVYNHYKRLRNATPKDGVELGKSNILLIGPTGSGKTLLAETLARVLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTIAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLEKVIEQRAHVGTGIGFGAEVKGEADKKSISDTLLQVEPEDLVKFGLIPEFIGRLPVLATLSELDDEALIQILSEPKNAITKQFAALFEMENVELEFRDDALKAIALKAQTRKTGARGLRSIVEGILLDIMYDLPSTDDVAKVVIDESVVKGESSPILIYANSEAQTASAE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RLR17_PLAVT
Sequence: MRLFYFSAMSVIGLLARNNMVVVASDKPITAVETLGNPVHLHHEVVESGLVRSLRTREKDIQDSTVAKDDAIKVEEDRSSLIQTINTPRYAYWFSQQMTPLDVRRELHLPAHKLQAKPSKVYSGYVEYYNIHCSFFKYRDEPFCCVKEY
What is the function of this protein?
Effector that acts as a broad suppressor of cell death to interrupt plant immunity.  Inhibits cell death induced by cell death-inducing proteins, including the PAMP elicitor INF1 from P. infestans.
What are the official names of this protein?
Secreted RxLR effector protein 17.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus.
Protein: DCTN2_CHICK
Sequence: MADPKYADLPGIARNEPDVYETSDLPEDDQAEFEAELEELTSTSVEHLIINPNAAFEKFKDKRLGTDGVDFSDRISKSRTTGYESGEYEILGEGLGAKETPQQRYQRLQHEVQELIRDVEQIQSAVKESAAEEELTPMALARQLEGLKQQLVSCHLQKLLGPTAAIDFADPEGALAKRLQQQLEVPSVKKAAPAKSPPKAPGPTTDALTFELFWRRPEQDQFSQTAKIAELEKRLAQLEAMVRCEPDSQNPLLVGAEGTSLVETVQILQAKVNILDAAVLDQVEARLQRRPGSKVNEIAKHKAIVQDADTQSKIHQVVYEMMQRWDHMASSLPDVVQRLLTLRDLHEQASRFVQVLVHLDTTQQEVDVVQRLLAEVQKTMKENLAVVEDNFAEVEARIKRLQ
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.  In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity).  Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.  Involved in anchoring microtubules to centrosomes (By similarity).
What are the official names of this protein?
Dynactin subunit 2, p50 dynamitin.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunit 2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
Protein: SMD_TRIRC
Sequence: MISLLRLCSFLAAGSILVQGSPIIAPSAPTWDTPNNFTSPSNFTSKPGNEASPFWLIGHRVLTKGGVRAALGHGANALEVDITGWWNGWYGDHDGLPSSAGDKVADLFDEIAYRRRQGAQVSFVWLDLKNPDFNKNGVNIVSLMTLCREKLEPAGVRVLFGFYSSQTSGHAFRFVKQVLNENEAIGIDGSFEPVEKDFEKNGIRVEKRVFSSGLFNPDFNFGTCQDRASGVCTQLREGKESHKFGKVFGWTVSSYTRKDHVYKMMEVGVDGLIYGFVASHYYNHKDIRQTIRTIRGWLDEHRDTHRLATNDDNPWSMSSRKSS
What is the function of this protein?
Catalyzes the hydrolysis of sphingomyelin.  Sphingomyelinases D are produced by some spider in their venoms, but also by arthropods such as ticks, or pathogenic bacteria and fungi.  They might play a role in pathogenicity through different mechanisms, such as membrane destabilization and host cell penetration, but also pulmonary inflammation and cutaneous lesions.
What are the official names of this protein?
Sphingomyelinase D, SMase D.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelinase D/phospholipase D family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS8_SHESM
Sequence: MSMQDPIADMLTRIRNGQAANKVSVKMPSAKLKVAIAKLLKEEGYIADYAVADEAKPELEITLKYFQGQPVVETIQRVSRPGLRIYKGKNELPKVMGGLGVAIVSTSKGLMTDRAARLAGMGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PAPS1_HUMAN
Sequence: MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALMYEGRRVAILRNPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRVYWNDGLDQYRLTPTELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPSHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFISGTRMRKLAREGQKPPEGFMAPKAWTVLTEYYKSLEKA
What is the function of this protein?
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway.  The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase).  In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722).  Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487).
What are the official names of this protein?
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, PAPS synthase 1, PAPSS 1, Sulfurylase kinase 1, SK 1, SK1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the sulfate adenylyltransferase family.
Protein: ENO_ECO27
Sequence: MSKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQALIGKDAKDQAGIDKIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SYP_ALTMD
Sequence: MRTSQYLLATQKETPADAEVISHQLMLRAGMIRKLASGLYTWLPSGLRVLNKVANIVREEMNKAGAIEVLMPVVQPADLWEESGRWEEYGPELLRVKDRHQRDFVLGPTHEEVITALVRNEISSYKQLPLNLYQVQTKFRDEVRPRFGIMRGREFTMKDAYSFHLEDSCLEETYQKMYDAYCAIFSRMGLDFRAVIADSGSIGGNHSHEFHVLAESGEDAIAFSSDSDYAANVEMAAAVAPEKAVPSGADVETKDAKGKDFNAILKSVDANATNAVKVVLVKGANELNDKGEDVVCDKWVALVLRADHELNDIKAEKIDGVAIPLVEASFEQAKDVLGVSPFFADATNLPVPAYVDASAAALADFTTGAGAGGKVNVNVNWPDGINTVDIRNVVAGDASPDGQGTLDIKRGIEVGHIFQLGRKYSEAMNCGVLSETGKHQTLTMGCYGIGVSRIVAAAIEQNHDKFGIKWPDPIAPFKIALIPMNMHKSHRIKEAAEALYEELVALGIEVLFDDRKERPGVMFNDMELIGIPHSIVIGERNLDNQQVEYKNRRTGEKQLLDLSAAKEFVAAL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBS_YEAST
Sequence: MTKSEQQADSRHNVIDLVGNTPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIAKSMVEEAEASGRIHPSRSTLIEPTSGNTGIGLALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQNDKIQIVGADPFGSILAQPENLNKTDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQLISNEGVLVGGSSGSAFTAVVKYCEDHPELTEDDVIVAIFPDSIRSYLTKFVDDEWLKKNNLWDDDVLARFDSSKLEASTTKYADVFGNATVKDLHLKPVVSVKETAKVTDVIKILKDNGFDQLPVLTEDGKLSGLVTLSELLRKLSINNSNNDNTIKGKYLDFKKLNNFNDVSSYNENKSGKKKFIKFDENSKLSDLNRFFEKNSSAVITDGLKPIHIVTKMDLLSYLA
What are the official names of this protein?
Cystathionine beta-synthase, Beta-thionase, Serine sulfhydrase, Sulfur transfer protein 4.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: RL10_PSET1
Sequence: MALNLQGKQAIVAEVNEAANGALSAVVADSRGVTVGAITALRKEARANGVWMKVVRNTLAKRALEGTQFECLSDSFVGPSLIAFSSEHPGAAARIFSAFAKKNEKFELKTAAFEGNVVDAAMLATLPTYDEAVARLMSAMKEASAGKLCKTIEAVRVQKEEQAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: NARF_CAEBR
Sequence: MEDSGFSGVVRLSNVSDFIAPNLDCIIPLETRTVEKKNEEPQVNIRAKKTKNEENKPKEDKKSVKISLADCLACNGCITSAETVLVEEQSFGRLLEGIRNSKMAVITISPQTITSLAVKLEKTPEDLAKLIASFFRRHGVKYVLDSSFARQFAHSLAYEELLLTPSTSRPLLSSACPGFVCYAEKSHGELLIPKISKIRSPQAISGAIVKGYLAKKEGLSPCDVFHAAVMPCFDKKLEHRGNSLGTAELLEELVKEEGVAEDVEEEEENNWTTSLSRGIIIGEDGGASGGYADRIVRDFVAQNGGIVKTSKLNKNMFSTTVESTTTGEIVLRVAKVYGFRNVQNLVRKMKTKKEKTDYVEVMACPGGCANGGGQVRYETMDEREKRLAQVEELYEALPRGNSWEESVREEWKRLDTNYKNLLFTDYKPVETNVAQTLKW
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for maturation of extramitochondrial Fe/S proteins (By similarity).
What are the official names of this protein?
Probable cytosolic Fe-S cluster assembly factor oxy-4.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
Protein: CYO4_VIOOD
Sequence: GIPCGESCVWIPCISSAIGCSCKNKVCYRN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cycloviolacin-O4.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: LIPA_ANADF
Sequence: MTARKPGWLRVNVPGGARYQQVRDTVKGLALHTVCEEAHCPNVAECWGGGTATVMLMGDVCTRGCRFCNVKTDAHPPPLDPDEPRHLAEAIAELGLDYIVVTSVDRDDLPDGGAGHFADAIRRLKDIPQLLVEVLTPDFRGDAEAVRTVGRARPDVFANNLETVRRLTPVVRDLKAGYDQTLAVLARMKREFPRIVTKSSIMVGLGETEDELLEAMGDLRAAGVEILTLGQYLRPSAWHLPVVEYVKPEKFAAWREAGLGLGFRYVASGPLVRSSYRAAELFLRGELASRPPGP
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_TRIV2
Sequence: MIRSNKPPENSCLLYNKGLMPYLEAHAWQRSLLHQRIDYPNLEDVLILLEHPPVYTLGQGSSLEFLKFDPNQSEFEIHRIERGGEVTYHCPGQLVGYPILNLRRHRQDLHWYLRQLEEVIIRVLAVYGLKGDRLPSLTGVWLEGRKVAAIGIKVSRWITMHGFALNVCPDMTGFGRIVPCGITDKPVGSLAQWIPGITCEEVRVHVVQAFAEVFGLVLVES
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_PELUB
Sequence: MKKAVILFNLGGPDKIENVEPFLFNLFNDPAILNLPTILRYPLAKLISNRRAPVAKKIYKELGGSSPILKLTMAQSKALETKLNQTEIDSEYKCFIVMRCWNPRANDVIKDVQSFNPEEIILMPLYPQYSAATSGSSIKEWRDVCKKNNYHVKTNTICCYPTDQNFINAHTKEIIKKIKDLKNFKLIFSAHGLPEKNIKKGDPYQWQVEQSVKKIVENLNIENLDWILSYQSRVGPLKWIGPSTEDIIVENSKLAKHIVLVPIAFVSEHSETLVELDIEYKEIADANGCKNYTRVPALGTNEDFIKAMSELIIKKNEYKFSENLYPPKIQCPSNFKKCPCLNYE
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEDF_ECOL6
Sequence: MKNIVPDYRLDMVGEPCPYPAVATLEAMPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQQDGPTIRYLIQK
What are the official names of this protein?
Putative sulfur carrier protein YedF.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.