PharMolix/UniProtQA huggingface dataset:
Protein: APC1_HUMAN
Sequence: MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGSLQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVDSPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANVWPTKYGLLFERSASSHEVPPGSPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVVDHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFSEQGGTPQNVATSSSLTAHLRSLSKGDSPVTSPFQNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALGVHSFSGVQRFNISSHNQSPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNIREKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAAPVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSTPKPLSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELSNGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVGGHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLSKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAYLSGQPLEESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQLKMPVRALLRLAPLLLGNPQPMVM
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
What are the official names of this protein?
Anaphase-promoting complex subunit 1, APC1, Cyclosome subunit 1, Mitotic checkpoint regulator, Testis-specific gene 24 protein.
What is the protein family that this protein belongs to?
Belongs to the APC1 family.
Protein: MIAA_WIGBR
Sequence: MNENKCTDKINNLPKAIFIMGQTAVGKTKIAEILKKKLPVEIISVDSGCIYKGMNIGTDKPNVKKSSSDKYHLIDICEPNDYYSVENFRLDALKIMEKISKKGLIPLLVGGSMFYFKSLLHGLSNLPSYNIENKNLLKKKINEIGWYKSYIFLKKIDPIFASNIHPNDHYRLTRALEIYFSSGNIPTNLFKAKTKKLEYNIRQFSIMISDKKILYKKIKDRFFNMLKNGFKKEVEFLKNKKQINKNMPSMRCIGYKQMLAYLSGEINYKEMILFTISATNKLAKKQSTWLKKWKNINYIYNKDVYISSEEIFNILKKDNFID
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: PNCB_SINFN
Sequence: MPKTDIARRVYNHTWKLDPIIRSLLDTDFYKLLMLQMIWQLYPDVDATFSLINRTKTVRLAEEIDEQELRDQLDHARTLRFSKKEMIWLAGNTFYGRKQIFSPEFLSWLARFRLPEYELSRRDGQFELTFRGRWVETTMWEIPALAIINELRSRAAMKGLGPFTLDVLYARAKAKMWSKVEQLRQYPNLRISDFGTRRRHSFLWQRWCVEALKEGIGASFSGSSNVLLAMDNDLEALGTNAHELPMVAAALARNDKELAAAPYKVLQDWNQLYGGNLLIVLPDSFGTAAFLRNAPDWVADWTGFRPDSAPPVEGGEKILAWWKKKGRDPRDKLLIFSDGLDVDTIIKTYRHFEGRVRMSFGWGTNLTNDFAGCAPTEIGGLNPISIVCKVSEANGRPAVKLSDNPRKATGDPAEVERYLKFFGTEDFVEQTVRV
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: SLAF9_MOUSE
Sequence: MGALLWSLLLLLQEAKGFSGDDEDPEEVIGVLQESINLSLEIPSNEEIKHIDWLFQNNIAIVKPGKKGQPAVIMAVDPRYRGRVSISESSYSLHISNLTWEDSGLYNAQVNLKTSESHITKSYHLRVYRRLSKPHITVNSNISEEGVCNISLTCSIERAGMDVTYIWLSSQDSTNTSHEGSVLSTSWRPGDKAPSYTCRVSNPVSNISSRRISVGSFCADPGYPEKPSMLCLLVKSLFLLLLLAILTVGLCLFRAQKSYETPRVRKLKRNRIKLRKKGKSGPTPV
What is the function of this protein?
May play a role in the immune response.
What are the official names of this protein?
SLAM family member 9.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: Y010_MYCTO
Sequence: MQQTAWAPRTSGIAGCGAGGVVMAIASVTLVTDTPGRVLTGVAALGLILFASATWRARPRLAITPDGLAIRGWFRTQLLRHSNIKIIRIDEFRRYGRLVRLLEIETVSGGLLILSRWDLGTDPVEVLDALTAAGYAGRGQR
What are the official names of this protein?
Uncharacterized protein MT0013.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MED22_HUMAN
Sequence: MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLRDEISIDLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 22, Mediator complex subunit 22, Surfeit locus protein 5, Surf-5.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 22 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTPM1_MOUSE
Sequence: MAASAWLEAGLARVLFYPTLLYTVFRGRVRGPAHRDWYHRIDHTVLLGALPLKNMTRRLVLDENVRGVITMNEEYETRFLCNTSKEWKKAGVEQLRLSTVDMTGVPTLANLHKGVQFALKYQALGQCVYVHCKAGRSRSATMVAAYLIQVHNWSPEEAIEAIAKIRSHISIRPSQLEVLKEFHKEITARAAKN
What is the function of this protein?
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (PubMed:21641550, PubMed:21730175).  PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (PubMed:21641550).  Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity).  Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity).  Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).  May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (By similarity).
What are the official names of this protein?
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, PTEN-like phosphatase, Phosphoinositide lipid phosphatase, Protein-tyrosine phosphatase mitochondrial 1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: AVRB_STRVR
Sequence: MARSRGERTPAARRITSRNARFQQWQALLGNRNKRTRAGEFLVMGVRPISLAVEHGWPVRTLLYDGQRELSKWARELLRTVRTEQIAMAPDLLMELGEKNEAPPEVVAVVEMPADDLDRIPVREDFLGVLFDRPTSPGNIGSIIRSADALGAHGLIVAGHAADVYDPKSVRSSTGSLFSLPAVRVPSPGEVMDWVEARRAAGTPIVLVGTDEHGDCDVFDFDFTQPTLLLIGNETAGLSNAWRTLCDYTVSIPMAGSASSLNAANAATAILYEAVRQRISGRTATTP
What is the function of this protein?
Specifically methylates the 2'-O-ribose position of uridine-2479 in 23S ribosomal RNA.  Confers resistance to antibiotic avilamycin, an orthosomycin antibiotic.
What are the official names of this protein?
23S rRNA (uridine(2479)-2'-O)-methyltransferase, Avilamycin resistance protein B.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TsnR/AvirB family.
Protein: Y1061_STRMU
Sequence: MEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIAEEFDVSRQAVYDNIKRTEKILEDYEMKLHMYSDYVVRSEIFDAIMKKYPNDPYLQNKISILTTIDNRD
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein SMU_1061.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: YSAB_SHIBS
Sequence: MMMNAFFPAMALMVLVGCSTPSPVQKAQRVKVDPLRSLNMEALCKDQAAKRYNTGEQKIDVTAFEQFQGSYEMRGYTFRKEQFVCSFDADGHFLHLSMR
What are the official names of this protein?
Uncharacterized lipoprotein YsaB.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: R1AB_CVPFS
Sequence: LDSEVVTCFDNSIAGSFERFTTTRDAVLISNNAVKGLSAIKLQYGLLNDLPVSTVGNKPVTWYIYVRKNGEYVEQIDSYYTQGRTFETFKPRSTMEEDFLSMDTTLFIQKYGLEDYGFEHVVFGDVSKTTIGGMHLLISQVRLAKMGLFSVQEFMNNSDSTLKSCCITYADDPSSKNVCTYMDILLDDFVTIIKSLDLNVVSKVVDVIVDCKAWKWMLWCENSHIKTFYPQLQSAEWNPGYSMPTLYKIQRMCLERCNLYNYGAQVKLPDGITTNVVKYTQLCQYLNTTTLCVPHKMRVLHLGAAGASGVAPGSTVLRRWLPDDAILVDNDLRDYVSDADFSVTGDCTSLYIEDKFDLLVSDLYDGSTKSIDGENTSKDGFFTYINGFIKEKLSLGGSVAIKITEFSWNKDLYELIQRFEYWTVFCTSVNTSSSEGFLIGINYLGPYCDKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVIGLLRKGKLLIRNNGKLLNFGNHFVNTP
What is the function of this protein?
NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
What are the official names of this protein?
Replicase polyprotein 1ab, pp1ab, ORF1ab polyprotein.
Protein: TGT_LACE2
Sequence: MYKILKTDGRAKRAEFTTVHGTVQTPVFMNVGTVAAIKGAVATTDLQQIGTQIELSNTYHLHVRPGDKIIKQLGGLHKFMNWDKPILTDSGGFQVFSLAGLRKIKEEGVTFQSHIDGHKIFMGPEESMQIQSNLGSTIAMAFDECAPAKADRKYIQNSVDRTYRWLERCKKEMARLNSLPDTVNPDQMLFGIDQGGVFNDIRIDHAKRISELDLDGYAVGGLAVGETHEEMYDVLDNVVPYLPQDKPTYLMGVGTPANILESVDRGIDFFDCVYPSRNGRHGHVYTKFGKINLFNAKYETDTAPIEEGCGCPCCQNYSRAYVRHLLKAKEMLGMRLCVLHNLYYYNHLMTDIRAAIEEGRYAGFKEEALYQMKTYDKQ
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: INVA4_ARATH
Sequence: MASSDALLPISAREEEPLCPYTRLPMADPNQETHGPRRRRPFKGLLAVSFGLLFIAFYVALIATHDGSRSNDEGIDETETITSRARLAGVSEKRNDGLWKLSGDRNTPAFEWNNSMLSWQRTAFHFQPEQNWMNDPNGPLFYKGWYHFFYQYNPNAAVWGDIVWGHAVSRDLIHWVHLPIAMVADQWYDSNGVWTGSATFLPDGSIVMLYTGSTDKAVQVQNLAYPEDPNDPLLLKWVKFPGNPVLVPPPGILPKDFRDPTTAWKTSEGKWRITIGSKLNKTGISLVYDTIDFKTYEKLDTLLHRVPNTGMWECVDFYPVSKTAGNGLDTSVNGPDVKHIVKASMDDTRFDHYAVGTYFDSNGTWIPDDPTIDVGMTASLRYDYGKFYASKSFYDQNKGRRVLWSWIGESDSEASDVQKGWSSLQGIPRTVVLDTKTGKNLVQWPVEEIKSLRLSSKQFDLEVGPGSVVPVDVGSAAQLDIEAEFEINKESLDKIIGNASVVAEAEEFSCEKSGGSTVRGALGPFGFSVLATESLSEQTPVYFYVAKGKDSELKTFFCTDTSRSSVANDVVKPIYGSVVPVLKGEKLTMRILVDHSIVEAFGQGGRTCITSRVYPTTAIYGAAKLFLFNNALDATVTASFTVWQMNSAFIHPYSDEAVRALSRT
What is the function of this protein?
Possible role in the continued mobilization of sucrose to sink organs (PubMed:20207708).  Regulates root elongation (PubMed:16481625).
What are the official names of this protein?
Acid beta-fructofuranosidase 4, vacuolar, At beta fruct4, AtBETAFRUCT4, Acid invertase 4, AI 4, Acid sucrose hydrolase 4, Vacuolar invertase 4, Inv-V4, VAC-INV 4, VI 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 32 family.
What are the subcellular locations of this protein?
Vacuole. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single- pass type II membrane protein. Vacuole membrane; Single-pass type II membrane protein. Vacuole lumen. Note=Located in the lytic vacuole but not in the protein storage vacuole. Remains inserted into membranes on its way to the lytic vacuole, following the classical sorting pathway from the endoplasmic reticulum. Released into the lumen of the vacuole from the tonoplast through a proteolytic processing.
Protein: AT10D_MOUSE
Sequence: MTELLQWARHHWRRLSHGRAQGEDERPYNYASLLACGGKSSRTPRPAGKHRVVIPHLQCFKDEYERFSGTYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDCCWKNVTVGDFIRLSCNEIIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYTEQDSEVDPEKFSSRIECESPNNDLSRFRGFLEHANKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWCVLLLIVMCLTGALGHGIWLSRYENMLFFNIPEPDGRVISPVLTGFYVFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSTIQCRALNITEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENAKRLESYQEAVSEEEECTDTLGGSLSNMARPRAQGCRTVPSGPLGKPSAQLSGSTSAVGNGEGSGEVPHSRQAAFSSPMETDVVPDTRLLDKFSQLTPQLLTGLDGTAQSSPLETLYIMDFFIALAICNTVVVSAPNQPRQKIGLSSLGGMPIKSLEEIKNIFQKLSVRRSSSPSLASGKDSSSGTPCAFVSRISFFSRPKLSPPMEDESSQMDEIPQASNSACCTETEAQNRAVGLSVSSAEALSGPPPSASNLCYEAESPDEAALVYAARAYRCTLQSRTPEQVMVDFAALGSLTFQLLHILPFDSVRKRMSVVVRHPLSKQVVVYTKGADSVIMELLSVAASDGTNPEQQMIIRERTQRHLDEYAKRGLRTLCVAKKVMSDTEYAEWLRNHFLAETSIDNREELLVESAMRLENKLTLLGATGIEDRLQEGVPESIEALHQAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSQDACGMLMSAILEELQKRAQVSPELASSRKNFPQPSDAQGQGRAGLVITGKTLEFALQESLQRQFLELTAWCQAVICCRATPLQKSEVVKLVRNHHHVLTLPIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAISQFRHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSVPPIIYGVLEKDVSAETLLQLPELYRSGQRSEEYLPLTFWITLLDAFYQSLVCFFVPYFTYQGSDIDIFTFGNPLNTAALFIILLHLVIESKSLTWIHMLVTVGSILSYFFFALAFGALCVTCNPPSNPYGIMRKHMLDPVFYLVCVLTTFVALLPRFLYRVLQGSVFPSPVLRAKYFDRLPPEERAEALKRWRGTAKVNHVASKHASQSAAMSGRPTPGSSAVLAMKSATVSTVEQSTRETALDRGCSEPGASKMTGSSAS
What is the function of this protein?
Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane.
What are the official names of this protein?
Phospholipid-transporting ATPase VD, ATPase class V type 10D, P4-ATPase flippase complex alpha subunit ATP10D.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
Protein: GRPE_SERP5
Sequence: MSSKEQKTPNEQVSEEMEQQEVLPEAAEGVDLRDERIAELEAQLAEAQQHERDSLLRAKAEMENVRRRTELDIEKAHKFALEKFSGDLLPVLDNLERALELADKNNPELTAMIEGIELTLKSLQDVVRKYGIEIVGDTNVPFNPEVHQAMSLMESADHQPNHVMMVMQKGYTLNGRLLRPAMVAVSKAKA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL117_MIMIV
Sequence: MYWEFFDCVIFYYHKMEYSEKKEKIFETAEKFGMDFIDLQEKCNFWNQITLTGRRECKEVKKDFMKDFLSMAKNSVDFIEQQAHQQQINQHRQSHNRQTIVRDGNTIDCIMM
What are the official names of this protein?
Uncharacterized protein L117.
Protein: BIOD_XANCP
Sequence: MQFPAFYVTGTDTGIGKTVASTALLHAVRARGHTAVGMKPVASGCVATPQGWHNEDALALQAASQPQPDYATLNPYALPAALAPELAAADVGVSLSLVPLQLAFAQLRAQAEVVVVEGVGGWAAPLSAQLDQADLVRALQLPVVLVVGVRLGCINHARLTAAAIAADGLRCIGWIANEIDPQMERIEDNIRMLGQRLAMPCWGRIPWRPNAQAEALAQHIRLPQ
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASNA_HAEI8
Sequence: MKKTFILQQQEISFVKNTFTQNLIEQLGIIEVQGPILSQVGNGMQDNLSGIEKAVQVNVKCIPNAIFEVVHSLAKWKRHTLARFNFKEDEGLFVHMKALRPDEDSLDPTHSVYVDQWDWEKVIPEGRRNFAYLKETVNSIYRAIRLTELAVEARFDIPSILPKQITFVHSEDLVKRYPDLSSKERENAICKEYGAVFLIGIGGKLSDGKPHDGRAPDYDDWTTESENGYKGLNGDILVWNDQLGKAFELSSMGIRVDESALRLQVGLTGDEDRLKMDWHQDLLNGKLPLTIGGGIGQSRLAMLLLRKKHIGEVQSSVWPKEMLEEFSNIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLTF_PSEMY
Sequence: MFARPAIRMRCATGLLAIGTLLMLAGCGEEPKPSVLEQVKAEGELRVVTRNSPATYFQDRNGATGFEYELAKRFATDLGLELKIETADNLDSLFASLGHVDGPVLAAAGLVETPQRQRQARFSVPYLEVTPQIIYRQGETRPTKAEDLLGKRILVLAGSSHAEQLEALKLELPELTFEVSDAVEVVDLLRMVDEGQIDLTLVDSNELAMNQVYFPNVRVAFDLGDTNTMRWAVAPGEDDSLLLEIDAFLERSQANGTLQRLKERYYGHVDVLGYVGAYTFAQHLQQRLPRYEKMFRQAGHANQIDWRLLAAMGYQESLWQPNATSKTGVRGLMMLTQRTAQSVGVSNRLDPKQSIDGGARYFVQIHQQLPESIQEPDRTWFALAAYNVGGGHLEDARKLTEAEGLDPNKWMDVQKILPRLAQKQWYSKTRYGYARGGEPVHFVRNVRRYYDILTWVTQPQLEGTQVAENGIHLPGIDKRTLDEQTPPL
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: AGAI_ECOLI
Sequence: MERGTASGGASLLKEFHPVQTLQQVENYTALSERASEYLLAVIRSKPNAVICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFRSEEINETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLDARTQQHEMLKTAGRPVTRGITLGLKDILNAREVLLLVTGEGKQDATDRFLTAKVSTAIPASFLWLHSNFICLINT
What are the official names of this protein?
Putative deaminase AgaI.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
Protein: KDSA_HAEDU
Sequence: MANKSVTVGQLEIANDRPFTLFGGMNVLESRDMAMRVCEKYVAVTNKLNVPYIFKASFDKANRSSIHSYRGPGMEEGLKIFQELKQTFGVNIITDVHEIYQCQPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIVECGNQQIILCDRGTNFGYDNLVVDMLSFNIMKKVSDGCPVIFDVTHALQCRDPFGSASGGRRDQVTELARAGLATGLAGLFLEAHPDPNTAKCDGPSALPLDKLEAFVAQMKAIDNLVKSFAELDTACRD
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_PELTS
Sequence: MAKAIMVQGTASHVGKSILVTALCRIFRQDGYRVVPFKAQNMALNSFVTADGGEMGRAQVLQAQAAGLEPAVEMNPVLLKPTGNAASQVIVLGKPVGNMSARDYHLGKNQDLLGIIEETLRRLHREYEIIVIEGAGSPAEVNLKERDLANMRVSRLAGAPVLLVADIDRGGALAAVVGTLALLEPEEAEQVRGIVINKFRGDRSLLDPALEFLEARTGKPVLGVLPYLQGLRLPAEDSVCLEEADTAAEGELEIAVLYLPRISNFTDFDSLALEPGVRLRYVKDGEPLGSPDLVIIPGTKNTTEDLLYLYETGYAAAVRRAAAQGIPVCGICGGYQMLGRELRDVEHSESFRDELPGLGLLDVVTTFVGEKILARARGEVCGGGPLFQEIAGLPVAGYEIHMGRTVLGEGTRPLLRVVEREGGGGGDFDGAVAPSGLVWGTYFHGIFDNDLLRAHLLGWLRRRRGLSQGTLEEKAGGGRGSTCLERELDRLAGAYRAHLNLEKIYALLGLPGPRLPRPGAGGGPK
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: GCST_PARD8
Sequence: MKTTPFTDVHIALGAKMHEFAGFNMPIEYSGIIDEHMTVVNGVGVFDVSHMGEFWVKGPNALAFIQSVTSNDASVLPLGKAQYTCFPNDKGGIVDDLLVYHYEPEKYLLVVNAGNIDKDWEWCVSHNTVGAELENSSDRTAQLAIQGPKAQEVLQRLTPVDLSSIPYYSFVTGEFAGCKNVIISNTGYTGAGGFELYFYPSDGMTIWNAIFEAGKPEGIKPIGLGARDTLRLEMGFCLYGNDLDDTTSPIEAGLGWITKFAEGKNFTNRAELERQKKEGVTRKLCAFELQEKGIPRHGYEIADAEGNVIGVVTSGTMSPVLKKGIGMGYVKPEFAKAGTDIFIKVRNKNLKAQVVKAPFRK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: EUTC_LISMC
Sequence: MNEQELKQMIEGILTEMSGGKTTDTVAAAPTKSVVETVITEGSIPDITEVDIKKQLLVPEPADREGYLKMKQMTPARLGLWRAGPRYKTETILRFRADHAVAQDSVFSYVSEDLVKEMNFIPVNTKCQDKDEYLTRPDLGREFDNEMVEVIRANTTKNAKLQIVVGDGLSSAAIEANIKDILPSIKQGLKMYNLDFDNIIFVKHCRVPSMDQIGEITGADVVCLLVGERPGLVTAESMSAYIAYKPTIGMPEARRTVISNIHSGGTPPVEAGAYIAELIHNMLEKKCSGIDLK
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: RL35_EHRCR
Sequence: MPKLKTKSSVKKRFSVTATGKIKSTQSAKRHGMTKRSKRSIRVQRGTAIMNSSDSRIVKLFMPYSR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.