PharMolix/UniProtQA huggingface dataset:
Protein: FENS_LAVST
Sequence: MSSLVMHVGIVNKPAITYLPTLSRRASNLHNVSSTRLQTSCSLQLDYKPVDETRRSGNYQPSAWDFEYIQSLKNKYKEEKYLTRHTKLTVQVKMLLDEDMEAVQQLDFIEDLNNLGISYLFKDKITQILNHIYNEHRCFHNNEAEESDLYFTALGFRLLRQHGFKVSQEVFDCFKNEKYTNFKASLAGDTKGLLQLYEASFLLREGEDTLELARKFSTKLLQQKIDEGEPDNNLLSCIRHSLELPLHWRLQRLEARWFLDAYATRHDMNPIIFELAKLEFNITQATQQEELKDLSRWWNSTGLAEKLPFARDRIVESYFWAMGTFEPHQYGYQRELVSKIIALTTVVDDIYDVYGTLEELELFTDVIRRWETESIDELPYYIQLCYLAVNKFVFDLAHDVLKDKGFNSLPYLKRSWKDLIERYLIEAKWYHNRYTPSLEEYLNNARVTITCPTILSQIYFALASPIEKPVIEVMYKYHDILYLSGMLLRLPDDLGTAPFELKRGDVPKAVQCYMKERNVPEKEAREHVRFLIREASKQMNTAMAIDCPFTEDFAVAAANLGRVANLAYVEGDGFGVQHSNIYEHIGSLMFKPYA
What is the function of this protein?
Monoterpene synthase involved in the biosynthesis of volatile compounds widely used in aromatherapy and folk medicine, and present in culinary herbs (PubMed:24943828).  Mediates the conversion of (2E)-geranyl diphosphate (GPP) into alpha fenchol, limonene and alpha-pinene and, as minor compounds, into beta-myrcene, alpha-terpinolene and alpha-phellandrene (PubMed:24943828).
What are the official names of this protein?
(-)-endo-fenchol synthase, chloroplastic, Alpha fenchol synthase, LsFENS, Alpha pinene synthase, Limonene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TSAD_HELAH
Sequence: MILSIESSCDDSSLALTRIEDAKLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNKDFSKLKAIAITNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKKTCMPLSVLLVSGGHSLILEARNYEDIKIMATSLDDSFGESFDKVSKMLNLGYPGGPVIEKLALDYAHKNEPLMFPIPLKNSLNLAFSFSGLKNAVRLEIEKNAPNLNEITKQKIGYHFQSVAIEHLIQQTKRYFKTKRPKIFGIVGGASQNLVLRKAFENLCDEFDCKLVLAPLEFCSDNAAMIGRSSLEAYQKKHFVPLEKASISPRTLLKKALSE
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THA10_PONAB
Sequence: MPARCVAAHCGNTTKSGKSLFRFPKDRAVRLLWDRFVRGCRADWYGGNDRSVICSDHFAPACFDVSSVIQKNLRFSQRLRLVAGAVPTLHRVPAPAPKGGEEGDQAGRPDTRGELQAARHSEAAPGPVSCTRPRAGKQAAASQYSVGTEEITCENEVVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSEIDTDWDIKSEQSDLSYIAVQVKEETC
What are the official names of this protein?
THAP domain-containing protein 10.
Protein: ISPF_DESAL
Sequence: MRVGYGYDVHRLVDGRPLVLGGVTIPFDKGLKGHSDADVLLHAVCDALLGAAGLGDIGMHFPDKDPKYKNIASTRLLEETGRKIAQEGYKIVNLDATLVAEAPKIGPYRQEMVSVIAKCLGLENRQVNVKATTTEGLGITGRGEGMAATCVACLE
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: THIG_BRASO
Sequence: MLKFYDKTVTSRLLIGTALYPSPAIMQDAIRASGAEIVTVSLRREAAGGKTGDAFWKLINELNVTVLPNTAGCRSVREAVTTAKLARELFGTSWIKLEVIGDNDTLQPDVIGLVEAATILIKDGFEVFPYCTEDLTVATRLVDAGCRVVMPWAAPIGSAKGIINRDALKLLRDRLPDITLVVDAGLGAPSHAAGALELGYDAVLLNTAIAKAADPVAMARAFRLGVEAGRTAYEAGLMDARDFASPSTPVVGTPFWHAVS
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UFM1_CAEEL
Sequence: MSGGTAATTAGSKVTFKITLTSDPKLPFKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGVGVNPAQPAGNIFLKHGSELRLIPRDRVGH
What is the function of this protein?
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (By similarity).  The so-called ufmylation requires the ufm-1-activating E1 enzyme uba-5, the ufm-1-conjugating E2 enzyme ufc-1, and probably the ufm-1-ligase E3 enzyme ufl-1 (PubMed:23449979).
What are the official names of this protein?
Ubiquitin-fold modifier 1, cUfm1.
What is the protein family that this protein belongs to?
Belongs to the UFM1 family.
Protein: IDI2_THET2
Sequence: MNIRERKRKHLEACLEGEVAYQKTTTGLEGFRLRYQALAGLALGEVDLTTPFLGKTLKAPFLIGAMTGGEENGERINLALAEAAEALGVGMMLGSGRILLERPEALRSFRVRKVAPKALLIANLGLAQLRRYGRDDLLRLVEALEADALAFHVNPLQEAVQRGDTDFRGLVERLAELLPLPFPVMVKEVGHGLSREAALALRDLPLAAVDVAGAGGTSWARVEEWVRFGEVRHPELCEIGIPTARAILEVREVLPHLPLVASGGVYTGTDGAKALALGADLLAVARPLLRPALEGAERVAAWIGDYLEELRTALFAIGAKNPKEARGRVERV
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPB41_BOVIN
Sequence: MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVSGRLPCSFATLALLGSYTIQSELGDYDPELHGADYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKEKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVEPADRTPRPTSAPAIAPSPAAEGGVPGAPVKKAQKETVQVEVKQEEAPPEDAEPEPSEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTETKTITYEAAQTDDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE
What is the function of this protein?
Protein 4. 1 is a major structural element of the erythrocyte membrane skeleton.  It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction.  Recruits DLG1 to membranes.  Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
What are the official names of this protein?
Protein 4.1, P4.1, 4.1R, Band 4.1, Erythrocyte membrane protein band 4.1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Protein: PUR3_STAEQ
Sequence: MTNIAIFASGSGSNFENIVKHIQTGQLSGINVTALYTDNEGVPCIDRAKNLNIPIHINKPKDFSSKSLYEQHLLKLLSSEEVQWIVLAGYMRLVGQDLLQAYEGRILNIHPSLLPKFKGLDAIGQALESGDTVTGSTVHYVDSGMDTGEIIEQQQCDIKPDDTKEQLEDRVKHLEYELYPRVIAKIIK
What is the function of this protein?
Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
What are the official names of this protein?
Phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase, GAR transformylase, GART.
What is the protein family that this protein belongs to?
Belongs to the GART family.
Protein: RT15_RAT
Sequence: MLRAAWRALSSVRVQAVTQAPVPALRARSSASLPSARCGLQTPSLLNAARAYAVQKPVQAKQDDEPASSTFIKEYKNIIPNMEKVDDVVKRILSLEMASRKEKLKIKREQLMNKIAENPEDYRTLEARIVALTVKIRNYEEHMQKHRKDKVHKRHLLMSIDQRKKFLRLLRQTNYDVFEKTCKELGVEYALPPLHFQRVHRRFLAKKALCIQVFQEVQKLKKQRMALKAAAAAAKKEKRERVPENPSNALPEKTKEN
What are the official names of this protein?
28S ribosomal protein S15, mitochondrial, MRP-S15, S15mt.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MLO1_ARATH
Sequence: MGHGGEGMSLEFTPTWVVAGVCTVIVAISLAVERLLHYFGTVLKKKKQKPLYEALQKVKEELMLLGFISLLLTVFQGLISKFCVKENVLMHMLPCSLDSRREAGASEHKNVTAKEHFQTFLPIVGTTRRLLAEHAAVQVGYCSEKGKVPLLSLEALHHLHIFIFVLAISHVTFCVLTVIFGSTRIHQWKKWEDSIADEKFDPETALRKRRVTHVHNHAFIKEHFLGIGKDSVILGWTQSFLKQFYDSVTKSDYVTLRLGFIMTHCKGNPKLNFHKYMMRALEDDFKQVVGISWYLWIFVVIFLLLNVNGWHTYFWIAFIPFALLLAVGTKLEHVIAQLAHEVAEKHVAIEGDLVVKPSDEHFWFSKPQIVLYLIHFILFQNAFEIAFFFWIWVTYGFDSCIMGQVRYIVPRLVIGVFIQVLCSYSTLPLYAIVSQMGSSFKKAIFEENVQVGLVGWAQKVKQKRDLKAAASNGDEGSSQAGPGPDSGSGSAPAAGPGAGFAGIQLSRVTRNNAGDTNNEITPDHNN
What is the function of this protein?
May be involved in modulation of pathogen defense and leaf cell death.  Activity seems to be regulated by Ca(2+)-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity).
What are the official names of this protein?
MLO-like protein 1, AtMlo1, MLO protein homolog 1, AtMlo-H1.
What is the protein family that this protein belongs to?
Belongs to the MLO family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TSAD_XANOR
Sequence: MKVLGIESSCDETGVAVYDTALSGVPALRAHAVYSQIALHAEYGGVVPELASRDHVRKLLPLIRQTLGEAGVGIDELDGVAYTAGPGLVGALLVGAGVARSLAWALDVPAIGVHHMEGHLLAPLMEDDPPEPPFVALLVSGGHTQLVSVKALGSYEVLGETLDDAAGEAFDKTAKMMGLPYPGGPQLAALAETGTPGRYRFARPMTDRPGLDFSFSGLKTQVLLAWRSSDQSDTTRADIARGFEDAVVDTLVIKCLRALDAAECNTLVVAGGVGVNKRLRARLQEAAQRRGGRVCFPRPALCTDNGAMIAFAGALRLQAGERADAAVHVTPRWDMAALPPLAAGRDSGVEIREW
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HNDLA_XENLA
Sequence: MAGFGAAPDFNEGSKINASKNQQDEGKMFIGGLSWDTSKKDLTEYLSRFGEVLDCTIKTDPVTGRSRGFGFVLFKDAVSVDKVLETNEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPETTEEQIKQYFGGFGEIENIELPIDTKTNERRGFCFVTYTGEEPVKKLLESRFHQIGTGKCEIKAAQPKEVYRQQQQKQQRGGRGAVTGRGGTRGRGRGQGWNQGYNNYYDQNYGGYGNNGSYGDQDYNSYSGYDYSGYSYGYNPGYTEYSGQQSTYGKARGGGNHQNNYQPY
What is the function of this protein?
Acts as a transcriptional regulator.  Binds DNA and RNA (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein D-like-A, hnRNP D-like A, hnRNP DL-A.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MTND_XANOR
Sequence: MSRLRIFADTNPATPEFDSRDGDAIASELKKIGVTFERWHASAPVEPGATPEQVMDAYRADIDRISAERGFKTVDVVSIAPDNPKREEMRAKFLDEHFHKEDEVRFFVAGSGLFTLHVDAKVYEIECVKDDLIAVPDSTLHWFDMGPEPHFVAIRFFTEPDGWVGHFTGTEIAKQFPRYAPEKPHKAS
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: HIPL2_HUMAN
Sequence: MLRTSTPNLCGGLHCRAPWLSSGILCLCLIFLLGQVGLLQGHPQCLDYGPPFQPPLHLEFCSDYESFGCCDQHKDRRIAARYWDIMEYFDLKRHELCGDYIKDILCQECSPYAAHLYDAENTQTPLRNLPGLCSDYCSAFHSNCHSAISLLTNDRGLQESHGRDGTRFCHLLDLPDKDYCFPNVLRNDYLNRHLGMVAQDPQGCLQLCLSEVANGLRNPVSMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQPFLDLKNIVLTTPWIGDERGFLGLAFHPKFRHNRKFYIYYSCLDKKKVEKIRISEMKVSRADPNKADLKSERVILEIEEPASNHNGGQLLFGLDGYMYIFTGDGGQAGDPFGLFGNAQNKSSLLGKVLRIDVNRAGSHGKRYRVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDPITRQGRGRIFCGDVGQNRFEEVDLILKGGNYGWRAKEGFACYDKKLCHNASLDDVLPIYAYGHAVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKNKKWKKQDLCLGSTTSCAFPGLISTHSKFIISFAEDEAGELYFLATSYPSAYAPRGSIYKFVDPSRRAPPGKCKYKPVPVRTKSKRIPFRPLAKTVLDLLKEQSEKAARKSSSATLASGPAQGLSEKGSSKKLASPTSSKNTLRGPGTKKKARVGPHVRQGKRRKSLKSHSGRMRPSAEQKRAGRSLP
What are the official names of this protein?
HHIP-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the HHIP family.
What are the subcellular locations of this protein?
Secreted.
Protein: YBEY_MYCUA
Sequence: MSIEVSNESGIDVSETELVSVARFVIGKMDVNPGAELSMVLLDTAAMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPAMLGDIVLCPEFAAEQAAAAGHSLGHELALLTIHGVLHLLGYDHGEPDEEKEMFALQDRLLEEWVAEQVQAYQQDRQDERDRRLLDKSRYFDEP
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRD3_CANGA
Sequence: MLLSTYLNWASVLLTIAGAESNIDPWDEVSSFLQGKLRKLDVTNPNAYDMNDNEQDATFYVSMDYHEEEERSEYESVWQYYNENSDQDWHKSVYDKLQVSADQFNNTEAMYKLSQINLWGQYGYPHNKSVAFQYLQKFNDMTSYENSSALFDLAVAYSTGLFGTLPVDVARGLLYFQRSARLGDLKAKQVLAYRYFSGYSVARDVDKALLLYKEIAEEIKKKYSEEQWNMVFPYIESYIVRIPDFDEGLLGKGLSTVPQSVRRKKTTRPPFAGSSNLKPIGDVGYGEVVMQFKFNAGNGNPGSFVISDSEHEDRLVELFYTAWDLYKGTYTRGRDCDKAKRLLLQVYKTYDAEVKYMDNLQKFFYVKSLDLLAHMYFTGEGFERPNVQAALDLFDRSEKILEGAEISRTASEVDKGLISQYYFNNTLGALKHYKKAKESGNAHGILFYQLGKLSEKNPELKIGDPYLYMQEASSQQYLPAQYEFAKMVESNELRKYSVEDITRLYKAFVEENENIMAPHLRLGFSELLGGSSEVSLYAYAQAAEQGYEAAQISAAYLLYQLPYKFDDPPETTIERKTMAISYYTRAFKQGNTDAAVVAGDIYFQMKNYTKALSLYQSAALKFSAQALWNIGYMYEHGLGVEKDFHLAKRFYDQILEHNQKLYFAVKASVMKLQLKSWFMWLNGKELDNISIDQEQESTVVRPFFDRLVQLLKNLSRETRGDNKKKNQHRILKEKKTPSQGIMERFGLQTEDLLTMVCVLIIFAISMFFRTVAPRGQWNVRINGVNIAGGNALGEEGNPENENEEDDENDDEGRARARNNFGFGNNFDVQVFAI
What is the function of this protein?
Component of the endoplasmic reticulum quality control (ERQC) system involved in ubiquitin-dependent degradation of missfolded endoplasmic reticulum proteins.  Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).  ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1.  Ubiquitinated substrates are then removed to the cytosol via the action of the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex and targeted to the proteasome.  ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M.  Stabilizes the HRD1 ubiquitin-protein ligase.  Has also a function in recruiting misfolded protein substrates (By similarity).
What are the official names of this protein?
ERAD-associated E3 ubiquitin-protein ligase component HRD3.
What is the protein family that this protein belongs to?
Belongs to the sel-1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: PDIA2_MOUSE
Sequence: MDKQLLPVLLLLLGVSGSWGQGEEPGGPSEVLPEEPTGEEVPKEDGILVLNHRTLSLALQEHSALMVEFYAPWCGHCKELAPEYSKAAALLAAESAVVTLAKVDGPAEPELTKEFEVVGYPTLKFFQNGNRTNPEEYAGPKTAEGIAEWLRRRVGPSATHLEDEEGVQALMAKWDMVVIGFFQDLQGKDMATFLALAKDALDMTFGFTDQPQLFEKFGLTKDTVVLFKKFDEGRADFPVDKETGLDLGDLSRFLVIHSMHLVTEFNSQTSPKIFAAKILNHLLLFVNQTLAQHRELLTDFREAAPPFRGQVLFVMVDVAADNSHVLNYFGLKAEEAPTLRLINVETTKKYAPTGVIAITAASVAAFCQAVLHGEIKHYLLSQEIPPDWDQGPVKTLVSKNFEQVAFDETKNVFVKFYAPWCSHCKEMAPAWEALAEKYKDREDIVIAELDATANELEAFSVLGYPTLKFFPAGPDRKVIDYKSTRDLETFSKFLDSGGHLPKEEPKEPAASAPEAQANSTLGPKEEL
What is the function of this protein?
Acts as an intracellular estrogen-binding protein.  May be involved in modulating cellular levels and biological functions of estrogens in the pancreas.  May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity).
What are the official names of this protein?
Protein disulfide-isomerase A2, PDIp.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: SSRP_XANP2
Sequence: MSSKKTEAPRKIAADNRRARFDFEIGETFEAGVMLTGTEVKSLRTGKATIGESYAAQKAGEMWLYNAYIPEYLEANRFNHETRRPRKLLLHKRQIAKLGHAVEREGMTVVALKIYFNDQGRAKVELALAKGKKAHDKREASKERDWARDKARLMRDRG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: EFTS_PSECP
Sequence: MANYTAADIKALRERTGAGMMDVKKALDEANGDAEKAIEIIRIKGLKGATKREGRSTAEGLVAAKVSNGVGVMIEVNCETDFVAKADKFIQLADKVLAVAVESGAADLETLLATDVDGKPLSEVVIEEGAVLGEKVVVRRISRIEGATVDAYLHKTSKDLPAQVGVLFAVDGESEAAATAAHDVAVHIAAMAPNYLTREDVPSDLVESERRIAEETAKAEGKPEAALTKIVEGRVTGFYKGEVLVDQAFAKDAKKSVAQILEEAGVKGTAFARFRVGS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG1_NEOFI
Sequence: MSIGRYTRLDEIGRGSFATVYQGVHTKTRTYVAIKSVNLSKLNKKLKDNLSSEIHILKGLYHPHIVALIDCHETTSHIHLVMEYCALGDLSLFIKRRDTLGDHRYTRDMIAKYPNPPGGALNEVVVRHFLKQLASALKFLRDRNLIHRDIKPQNLLLCPSPSSYRSGVTQVVPFKGSEDSFNPATGLESLPLLKIADFGFARSLPATSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVVGKPPFRATNHVELLRKIEKGEDRIKFPEENPASDEIKALIRALLKRNPVERLNFPDFFENGVITSPIPGLVADDQPSIPRDPPADPETAESTPRPDSRSGAIVPGGTEREREVSYLPKGDTGLTQRPPSQNQRFGTPPTTTHMRRIGSGDRPPSTPKELTPPMTYPQRPSAVSHATAPGRQELVDRNAAFTAMERQRGRNTFSEGSPQTDRQADKLREERERAAQDVAFERDYVVVEKRAVEVNAFADELAHSPRIQGGISRGAQTGALSRRSTVHGPTPLNPSPPQATVGKAMQVLSGRSRADSMHNRQSSYERRYGQSPTSATSAISKALNMASGRLFGMGFSPPLAITKGGRSPPLAYNPFPAYPAHGSLMIGDGAKNNVALDEDTKTVQILEECATRSDVVYGFAEVKYKQLVPLAPSVQTDPSSKGNLAGERENPDSADGGLTVDAIVTLSEEALVLYVKALSLLAKSMDIAGAWWARKNRGDGFGDSAMSRADGASTLAGTRINNVVQWVRNRFNEVLEKGEFVRLKLIEAQKRLPPDHPSHPDNHSVGSSLGSGASVDVVVSPGVSAEKLMYDRALEMSRTAAINELTGEDLSGCEIAYVTAIRMLEAVLENGEVPRFGQGKDDTSKDSDKIVLDAVQAEERQVVIKLVSSIRSRLAALRKKLAILAKRAPTPSANVPSKMAPLNPVSVGATPPK
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
What are the official names of this protein?
Serine/threonine-protein kinase atg1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: RBFA_LACLA
Sequence: MGNSFRSDRVAVEIQREINDILRNKVRDPRVQDVNITDVQLTGDLSQATVYYSLLSNLASDNEKAATALKKATGLFKSELAKRMTIFKIPDLTFAKDESVEYGSKIDELLRGLNNKSEY
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCMA_PARXL
Sequence: MLSIERLGVGRGGQMVASGIDLCIEAGWALQIHGANGSGKTTLLRVLAGLMPPAGGQVSWYGANVRAHPEKFRRDLAFVGHANGVNDDLTVLENLRFATLLGAGSGAPDGTSSVPASGRSGVAAPPSRRDMLARAGMLPLQHTRAGCLSQGQRRRVALARLMLDRKPLWLLDEPGDALDDSASGWLHECLALHMQDGGIVVATTHRSLQTPAARTRHLHLERSGAWLD
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.