PharMolix/UniProtQA huggingface dataset:
Protein: TRKH_HALED
Sequence: MSLRMILRILGLLLMMFSLTMVPPILISLLFADGMWQAFVVALGITVGTGALMYLPNRHARKELRTRDGFLIAALFWSVLGLFGSLPLMLTGAAALSPTDAVFESFSGLTTTGATVITGIDLLPEAILYYRQQLQWLGGMGIVVLAVAILPTLGVGGMALYRTEIPGPLKDSKLTPRITETAKALWYIYATLTVTCALAYMAAGMNWFDALGHSFSTVAIGGFSTHDASIGYFDSAAIELICSAFLLISAFSFSLHFVAWRERRLTHYFQDPEARFLMLFLAGLIIITSVSLWLTSDYETLQGLRHAVFEVVSIATTAGFSVADFSTWPGALPFLLFVAAFVGGCSGSTGGGMKVIRIILILKQGMREVMRLIHPSAVIAVKIGKVSVPDGIAQAVWGFFSAYVLLFFLMLVGVMATGVDQVTAWSTVGATLNNLGPALGEASAHYGDLPSLAKWILVVAMLLGRLEIFTVVVLFTPAFWRK
What is the function of this protein?
Low-affinity potassium transport system.  Probably interacts with Trk system potassium uptake protein TrkA.
What are the official names of this protein?
Trk system potassium uptake protein TrkH.
What is the protein family that this protein belongs to?
Belongs to the TrkH potassium transport family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSIM_PSICY
Sequence: MHIRNPYRDGVDYQALAEAFPALKPHVTVNSDNTTSIDFAVPEAQRLYTAALLHRDFGLTITLPEDRLCPTVPNRLNYVLWVEDILKVTSDALGLPDNRQVKGIDIGTGASAIYPMLACSRFKTWSMVATEVDQKCIDTARLNVIANNLQERLAIIATSVDGPILVPLLQANSDFEYDFTMCNPPFYDGASDMQTSDAAKGFGFGVNAPHTGTVLEMATEGGESAFVAQMVRESLNLQTRCRWFTSNLGKLKSLYEIVGLLREHQISNYAINEYVQGATRRYAIAWSFIDVRLPDHLSRPSNPDLSSLF
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product (PubMed:28763571, PubMed:30283667).  The first step in the pathway is the decarboxylation of L-tryptophan to tryptamine by the decarboxylase psiD.  PsiD does not decarboxylate phenylalanine, tyrosine, or 5-hydroxy- L -tryptophan (5-HTP) (PubMed:30283667).  4-hydroxy-L-tryptophan is accepted as substrate by psiD as well.  The cytochrome P450 monooxygenase psiH then converts tryptamine to 4-hydroxytryptamine.  The kinase psiK catalyzes the 4-O-phosphorylation step by converting 4-hydroxytryptamine into norbaeocystin.  The methyltransferase psiM then catalyzes iterative methyl transfer to the amino group of norbaeocystin to yield psilocybin via a monomethylated intermediate, baeocystin.  4-hydroxy-6-methyl-l-tryptophancan also be converted the decarboxylase PsiD, kinase PsiK, and methyltransferase PsiM into respectively 6-methyl-norbaeocystin, 6-methylbaeocystin, and 6-methylpsilocybin (By similarity).
What are the official names of this protein?
Psilocybin synthase, Psilocybin biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
Protein: MUTS_CLOK5
Sequence: MGLTPMMRQYMEIKENYKDCILFFRLGDFYEMFFDDAKIAAAELELVLTARECGLKEKAPMCGIPYHAAKSYIGRMVNKGYKIAICEQLEDPAQSKGIVKRGIIKVITPGTYMDSYFLDENENNYIMCLYINNNEGSNCALCFADISTGEFNCTDTPFNLSVILDEICKFNPREIIIQEDIDSNILQGIVEVFNETFSRVDECYFQKGEEVLREQFKDLNLREYTPEIIKCGGALVKYIKHTQKTNLSHINKFQYYNIVDYLTIDINSKRNLEIVESLRESKKKGSLLGVIDKTNTSMGGRQLRKWIEQPLIDRNKIMERLDSVEEILNNICYHEDLKEALKNIYDIERLAGKISSKSVNAKELNSLKSSIEKIPDIKVILSNFETSLLKNMYKNLDELKDIYMLLDKAILDNPSVSLKEGNLIKEGYDSEIDRLKEAKVKGKDWIASLESSERELTKIKSLKIGYNKVFGYYIEVTKSNLNLVPEHRYIRKQTLSNAERYITPELKEMEDKILGAEEKLIYLEYNAFVEVRDKVEKEVTRIQNSARIISEVDCLTSLARAALENNYCKPEITLSDRVYIEEGRHPVVENMLSTGEFVSNDTDIDTGENQLLLITGPNMAGKSTYMRQVALVTIMAQIGSFVPAKSASISICDKIFTRIGASDDLASGKSTFMVEMWEVSNILKNATNKSLILLDEVGRGTSTYDGLSIAWSVIEYICRESKLRCKTLFATHYHELTKLEGKIKGVKNYCVSVKEVENNIVFLRKIIRGGADQSYGIEVAKLAGLPEEVLKRAREILNSLETEKTEESMEGTNLPKKKKEEKTSSQGEQLKFLDIEKENLINEIRDIDILNMTPMEGFNKLYDIIKKVKSI
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: DAPF_CHRSD
Sequence: MLLHFTKMHGLGNDFVVIDLITQRARLDTERIRQLADRHVGIGFDQLLLVEPPRDPEMDFRYRIFNADGNEVENCGNGARCFARFVRDNRLTHKREIRVETQAGPLTLRVEDDERIRVDMGVPRFAPEVVPFDAPADAPAHCLEVDGETWDIGAVSMGNPHAVLRVDDVAQAPVARLGPLIERHPRFPRGVNVGFLQVVSRHEARLRVFERGSGETLACGTGACAAVAHGIRRGWLESPVDVHLPGGTLTLAWPAPDASLMMTGPATSVFEGRIALP
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP176_GIBF5
Sequence: MLQTIPMPSRELTIALAVLSLLMVLVQRAGSRRRETKQLLSLPPSPPCANIIAGHLPTVLKAAKEHRQHLLFQKWAEEYGEVFFVQLGTIQEYFINSDQAVRAIFDKAAAQTSERPRWIVSNEQICNRLNLLLLSSSEKAWKSQRKATTFGLTNLNLADAGLPFLHFETLKFLNDIGQNPSKGADPQSLWSSIGRYTYSTFSSQIFGLDVPEDNSPVIDYIFETGLAQILGMLPGYYLVDTFNILDKLPLFLKPWERDAKSRHKRDYEWCCDKLKKVKSQIDAGEAPPHMTFIRRVIEDPNHLGLDSLEDASYLGMMLIIGASDTSRISTWSFLEAMLTFPDVCNKARKVIDSAVGDRVPVFEDLERVPYIRQVMKESWRWRPPVALGHPHTTTRDIMYKNYRIPKGARIHLNAWAIHRDPTRYPDPENFIPERFEGDTRSSQESAASPDVSKRDHFVFGAGRRICPGYHVADRSFAVSVMRILWAFDISLKPGTKLPLDPQSFPGDMPGNPGLELPVVLTVRSPERLETIQKEFEAAVQSRERMEPLVG
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the DMATS1 gene cluster that mediates the biosynthesis of a reversely N-prenylated monomeric L-tryptophan (r-N-DMAT) (PubMed:28295904).  Seems not to contribute to the final DMATS1 product (PubMed:28295904).
What are the official names of this protein?
Cytochrome P450 monooxygenase FFUJ_09176, DMATS1 biosynthesis cluster protein FFUJ_09176.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: BLT3B_MOUSE
Sequence: MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAISKVFCNKASIRIPWTKLKTQPICLSLDKVIMEMSTCEEPRAPNGPSPIATASGQSEYGFAEKVVEGITVSVNSIVIRIGAKAFNASFELSQLRIYSVNAQWEHGDLRFTRIQDPQRGEVLTFKEINWQMIRIEADATQSSHLEIMCAPVRLITNQSKIRVTLKRRLKDCNVIATKLVLILDDLLWVLTDSQLKAMVQYAKSLSEAIEKSTEQRKSMAPEPTQSSTVTSSAQHVKTPQAANAPDLSDAIVKLFNDFDVKETSHHLVISHLDLHICDDIHAKEKESNRRVSGGAMQLSFTQLTIDYYPYHKAGDSCSHWMYFSDATKTKNGWANELLHEFECNVEMLKQAMKDRNLGSPPKSPTHASPQHTQTEKDSTLKGTPKTPSVLPQPSKAKLMSSSVVVRLADFNIYQVSTAEQCRSSPKSMISCNKKSLYLPQEMSAIYIEFTEYYYPDGKDFPIPSPNLYSQLNALQFTVDERSILWLNQFLLDLKQSLNQFMAVYKLNDSSKSDEHVDIRVDGLMLKFVIPSEVKAGCHQDQPHTVSIQSSEMIATNTRHCPNCRHSDLEALCQDFKECDFFSKTYTRFPKSCDSFNLLHPIFQRHAHEQDTKMHEVYKGNIIPKLNKNTLKTSAATDVWAVYFSQFWIDYEGMKSGKGRPVSFVDAFPLSIWICQPTRYAELQKEFQTCDQVTLNTSQSESSDLAGRMKRKKLLKEYYSTESEPLTNGGQRPSSDTFLRFSSSSSDADVHVLVRVHKHVSMQINHYQYLLLLFIHESLVLLSDTLRRDVEAVIGSPASQTSVCVGILLRSAELALLLHPVNPTSALRSPASESGSPLLPDFLPAENGGFLSSKRKQGGSGIHRIRNATLNHMSDNRSMSVDLSHAPLKDPLLFKSASDTNLQKGTSFLDYLSDKHLGKISEDESSGLSHKSGSGEMTSEGSHTKDVASTDSDSVLNYRDGSTRLSLDDDGNHNPPSNPVTGKGIDAIHSIFRAEDFLPEAASLSENPESSKEEAPPARAPKSQTSLSAKSKERCPPSPAPLSVSYKNMKRSASQVSLDTLSLDSMVLEEQAESDGSDSHVLLGKAMKRNSNTSCQSPAESVNTSANTQTCGEASPEAVSTNSEGTQENRDDLMSVVVFRITGVNGEIDIRGEDTEVCLQVNQVTPSQLGNVSLRHYLGNRPVGSDQKAIIHPKSSPEISLRFESGPGAVVHSLLAEKNGFLQCHIENFTTEFLTSSLLNIQHFLEDETVATVMPMKIQVSNTKINLKDDSPRGSTVSLQPSPVTVHIDRLVVERSDDGSFHIRDSHLFNTGTDFKDGASSDSVVRTRGMCDVRMHSSVTQATQTSPEVPLPSQSANFLDITREQLMEENECLRQRLAQAKMELAEAHSARDELLHQMKRMGL
What is the function of this protein?
Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites.  Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex.
What are the official names of this protein?
Bridge-like lipid transfer protein family member 3B, Syntaxin-6 Habc-interacting protein of 164 kDa, UHRF1-binding protein 1-like.
Protein: RL15_MYCMS
Sequence: MKLNELKYTPGSKTKATIVGRGMASGKGKTATRGHKGQNSRSGGGVRPGFEGGQTPLFRRLPKVGFTSLNQKQYTILNLSDLETLGLEKIDHESLINSKIIKNNASLIKILANGTLTKKVDVKVNKISKAAKDAIEKLGGKVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: TM41B_DANRE
Sequence: MAKKRAGNRETESSPLVEQEPRPSKETPVPKGAQSPGGASARMSILLLVVIFACSACVMYLVFRNFPQLSEDEREKIKIPKDMEDAKALGTVLSKYKDTYYTQVLLAYFATYIFLQTFAIPGSIFLSILSGYLYPFPLALFLVCLCSGLGASFCYMLSYLVGRPMVYKYLTERAQKWSQQVDKHREHLINYIIFLRITPFLPNWFINITSPVINVPLGVFFLGTFLGVAPPSFVAINAGTTLYKLTTAGEAVSWNSLLVLGVLAVVSILPVCFQKKLQQKLE
What is the function of this protein?
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes.  Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine.  Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by atg2 (atg2a or atg2b) to mediate autophagosome assembly.  In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity).  Required for normal motor neuron development (PubMed:23063131).
What are the official names of this protein?
Transmembrane protein 41B, Protein stasimon.
What is the protein family that this protein belongs to?
Belongs to the TMEM41 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endomembrane system. Note=Localized to specific membrane structures termed mitochondria- associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria.
Protein: RS3_CHLT2
Sequence: MGQKGCPVGFRTAVTKKWRSLWYGNNQEFGKFLIEDVKIREFLKKKPSCQGAAGFVVKRMSGKIEVTIHTARPGLVIGKKGAEVESLKAELKKLTGKDVWVEIAEVKRPELNAQLVADGIAKQIERRVSFRRAMKKALQSVMDAGALGVKVQVSGRLAGAEIARSEWYKNGRVPLHTLRADIDYATASAETTYGIIGIKVWINLGEKKAVPAANHAGAASTAAA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: NARU_ECOLI
Sequence: MALQNEKNSRYLLRDWKPENPAFWENKGKHIARRNLWISVSCLLLAFCVWMLFSAVTVNLNKIGFNFTTDQLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILIIPCVWLGIAVQNPNTPFGIFIVIALLCGFAGANFASSMGNISFFFPKAKQGSALGINGGLGNLGVSVMQLVAPLVIFVPVFAFLGVNGVPQADGSVMSLANAAWIWVPLLAIATIAAWSGMNDIASSRASIADQLPVLQRLHLWLLSLLYLATFGSFIGFSAGFAMLAKTQFPDVNILRLAFFGPFIGAIARSVGGAISDKFGGVRVTLINFIFMAIFSALLFLTLPGTGSGNFIAFYAVFMGLFLTAGLGSGSTFQMIAVIFRQITIYRVKMKGGSDEQAHKEAVTETAAALGFISAIGAVGGFFIPQAFGMSLNMTGSPVGAMKVFLIFYIVCVLLTWLVYGRRKFSQK
What is the function of this protein?
Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane.  May function as a nitrate/H(+) and nitrite/H(+) channel.  Could confer a selective advantage during severe nutrient starvation or slow growth.
What are the official names of this protein?
Nitrate/nitrite transporter NarU, Nitrite extrusion protein 2, Nitrite facilitator 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLYA_RHOP5
Sequence: MSTSAKTQSAPDQFFSASLAEADPEIAAAIAGELGRQRHEIELIASENIVSRAVLEAQGSVMTNKYAEGYPGHRYYGGCEFVDVAENLAIDRAKKLFGAGFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLAAGGHLTHGATVNMSGKWFKPVHYTVRREDGIIDMDEVAKIAEANKPKLIIAGGSAYSRAWDFKRFREIADSVGAYFMVDMAHFAGLVAGGVHASPVPHAHVCTTTTHKSLRGPRGGLILCNDEALAKKFNSAIFPGLQGGPLMHVIAAKAVAFKEALQPDFKVYAKNVVENAKALAETLRGHGFDIVSGGTDNHLMLVDLRPKALKGNVSEKALVRAGITCNKNGIPFDPEKPFVTSGIRLGTPAATTRGFGVAEFQQVGGMIAEVLNAIAQSSDGQAPLVEAAIRQRVKELTDRFPIYS
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALF1_PYRFU
Sequence: MEAPQNVGIKRRLKRFFRRDGRALIFAMDHGFEHGPTDFEPVWEHVNPRVIIRKVVRAGIDGVMMLPGLARIAGDEVKPEVGLMIKLTSKTNLRPKPEQLLQSQLGFVDDAIKLGADAIAATVYWGSPQEDVMMRQFAEIVSYAHDLGYPVVQFAYPRGPYIDEKYGKKEDYRVVMYGARAAAESGADMIKTYWTGSKETFAKVVEAAAGVPVLLSGGAKTENPVDFLKVVWEVIEAGGAGAVVGRNIFQRENPEPMIKALIRVIHRNEDPEEAAKAEGLI
What are the official names of this protein?
Fructose-bisphosphate aldolase class 1, Fructose-bisphosphate aldolase class I, FBP aldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_MYXGL
Sequence: MYLSRWFFSTNHKDIGTLYLIFGAWAGMIGTALSVIIRTELSQPGSLINNDQLYNTIITAHAFVMIFFMVMPIMIGGFGNWLVPMMIGAPDMAFPRMNNMSFWLLPPSLMLLLSSSLVSSGAGTGWTVYPPLSNHISHMGPSVDLAIFSLHLAGVSSILGAINFITTIINMKTRSMEMYHIPLFVWSILITAILLLLSLPVLAAAITMLLTDRNLNTTFFDPSGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTFYSGKKEPFGYMGMAWAMMAIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATIHGGDIKWEPPMLWALGFIFLFTVGGLTGIVLSNSSLDVVLHDTYYVVAHFHYVLSMGAVFAIMAGLMHWFPLFSGYSINKTWAKIHFWIMFTGVNLTFFPQHFLGLAGMPRRYSDYPDAYSTWNVLSSIGSMVSFVGTIILMFIIWEAFSSKREPNPLSLPLYNPEWIYGTPPTFHTFENPSYLKIIKKE
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BLO3_PSEAI
Sequence: MAIRIFAILFSTFVFGTFAHAQEGMRERSDWRKFFSEFQAKGTIVVADERQTDRVILVFDQVRSEKRYSPASTFKIPHTLFALDAGAARDEFQVFRWDGIKRSFAAHNQDQDLRSAMRNSTVWIYELFAKEIGEDKARRYLKQIDYGNADPSTSNGDYWIDGNLAIAAQEQIAFLRKLYHNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRIGWWVGWVEWPTGPVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR
What is the function of this protein?
This is an oxacillin-hydrolyzing beta-lactamase.
What are the official names of this protein?
Beta-lactamase OXA-3, Penicillinase.
What is the protein family that this protein belongs to?
Belongs to the class-D beta-lactamase family.
Protein: SOS_CAEEL
Sequence: MSIMSISLHSASSDTVSLTSRRTISTSKHWAAIFDERIYQICNIVHPGLPIDNAAVEHIRYFLQSIVFELIEARATSVVEVDKTAKKLFAFGLQTVCKEAWDNMHQQLQKHKYQKALKTVLESQHRLAAVIKETLGPREKEKKDREKKEIERIACYIYYACESVTEDVLRLTGNYVKNIRNSEQKITMANLDVAMNGDKALMELRTKLRNEEEAESPGGFGFLSEFEEFVAEETEEKTLSNSQTYESVAVDFLRDERRFIRELNRINVFRRRIESVAATDVDKQIVCNLFGNLTEIHDLALKIERTLEDAIELSDTQCIGMGIWEHGEAYEFDTYTFYIRRDGGEMNETRHATYVINDNIKALLESERFASLFQSGEHYLGSSLDGQSFRLAVQYVLPQLLHIPIFHIYQYHEYITRLHQLSSSEEDRRDLNDCRSAFERVVGCVSDMSPELKTKITQFLDQQAKSEKIYNVKRLNEIQSSIDGFTGSPIGKTCNELEKDGDLGMIRPSLQFSSEITKNKKWKTERFVYIFDQMIVLCKRHRNTLKFKDRLAVHSIDVFDIPDSEVTNCFKIESHDKSSLPKIYHFVCKNPEEKRQWMAVLVKVTTKSVLDRILDNHEKEEAKRIPLVVPGPDQYRFSEPDTEDNISFEDYTSSSGIPVIKCGTVLKLIERLTYHSYTDSKYILTFLISYRSFCTPNDLFSLLLERFNIPTPKKLQQPKQGGGPLAGRYDTVQSHGLSAISSSSCINPLCEQKFRKEFQQPIQLRVLSVINQWVKLHWYDFQCDPVLLDALELFLNRCCDPREGLSKQHKKFCKTILALIEKRVKNPPGIMQQPNENGDKGAADEGHVNSAFVFGDDQQHPPQHQVYTNESPKETNQVLWHTAQKGDVDHYDLLTLHPIEIGRQLTLLHSDLYRAIQPIELVEAAWTKAEKWRKSPQLLRLTDHSTLLTYWVSRSIVETESLEERMAMFNRVLEVMSVFEELHNFTGLVAFYSALNSSCIFRLKWCWDGLDNEKKKCFDRFNTLCERRWQEMQKRLSSINPPCIPFFGHYLSNIYFLEQGNSTFVNKSPPHGAAGAQKQQKDDLKASDPENSNKQFKQLVSFLKLRKISNVIREIQIFQDQRYSLTLEPTIRQFFESINPKNDFKSNEDLEEYLYNKSLEIQPKGLDTPTAELKPKHNASTLRSPGVKPPKAAGNHYSANHPIGLHLHSQNSHSAPHAMSSQSSTVPNTPLSAHETKRSLSHNQDDAPLQQFVDIRFERKGTHPKIPVLQPPPLLPRSSRANQSNSVSLPPTTQAPMPPAPKSSGMMSTATSPTTLTTTTTPSSAGGPPPKLHPRRMTQQPMSPLAKSPLTPSRDNSSPSAFQFPVVYEASTAPPLPPRPSTSSDVSSSPSTSGSTSSATKENQEQLRVIFDREESHSPTVRLSVPLPPALPPPRGSSVFRAPPPLPPKSNRHNSNSPTLSSEQPFEDPMSPSIFVNTPPPPLPPKTYRSSNK
What is the function of this protein?
Promotes the exchange of Ras-bound GDP by GTP (By similarity).  May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23 (PubMed:10880441).  Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation (PubMed:10880441, PubMed:17339331).  Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development (PubMed:25371363).  Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870).  Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord (PubMed:15990870).
What are the official names of this protein?
Son of sevenless homolog, Guanine nucleotide exchange factor for RAS.
Protein: SYE_GLOVI
Sequence: MNFEQYESAYPPRALPPGAWVTRIGPSPTGKAHIGTALQAVINRSLADGSGGAFLLRIEDTDRERFVEGAIEDLLAALDWLGIRPDESVAHGGAYGPYVQSERLPIYQAAARQLVEVGHAYYCFCTPERLESVRMAQQAAGKPTMYDRHCRNLGREEVEKRLATGEKAVVRLKVPDGTEIAFDDLARGRIAFESQTIDDSVLLKSDGFPTYHLAVVVDDHLMRVNQIIRGEEWIPSTPKHVLLYQYFGWPMPRIAHTPILRDMSRRKLSKRSGDTSITGYRVQGYLPEGLRNFLTRIIWPHPEGKDVYDHEEFVRLFKAEDLPNTGPIVDPQLLDFINGQYLRRLSSAELYTATVEYLKFLLGLHQDIIFETYHPSAPIKQTLTRAELGSFYSAFTANPTYTERVLTLEPERYKRLSDIVVSTGFFFPALFTPADPKLLAKPLGSPEKAGALLGEYLRLYRPDAAQAEWEQSVRELAHEAGVKDGKLFMTLRVAVTGREQTPPLFEVLTILGGDEVQRRLELAAAMPVSL
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAT2_SCHPO
Sequence: MSFTTLYSAIQGDASARALVAPSLNAELSFSELRIAIMDLQRQIASLGIKVGDPVNIAIPNGLEFVVAFYAVSWQRAICGPLNSNYKQSEFEFYIDDLKSKLVIVPEGSVAANTPAVRAAKKLSVAVAELAWCPKSRLVRIVHFEGAKINAPQPLGLPQPDDVMLVLHTSGTTGRPKVVPLTHKNLCRSIHNITTSYRLDPRDTSYVVMPLFHVHGLLCGLLSTLASGGCAVVPPKFSAHSFWKEFIQYGATWYTAVPTIHQILLRTPPPKPLPRIRFIRSCSSPLAPPVLSKLEATFRAPVLEAYAMTEASHQMTTNPLPPLVHKPHSVGKPFGVELKILDQKGNEMPQGKEGEICVRGINVTKGYLNNPAANKSSFTKDRFFRTGDEGKLDKDGYVFITGRIKELVNRGGEKISPAEIDAVLMQHPDVSEAVCFAVPDEKYGQDIQAAINPVAGKTVTPKQLHDYLEQKVAAFKIPKKFYFTDRIPKTATGKVQRRLVCDAFFNHSKAKL
What is the function of this protein?
Catalyzes the first step in a degradation pathway of oxalate to CO(2) to protect the cell against the harmful effects of oxalate derived from endogenous processes or an environmental sources.
What are the official names of this protein?
Oxalate--CoA ligase, Oxalyl-CoA synthetase, Peroxisomal-coenzyme A synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome matrix. Peroxisome membrane; Peripheral membrane protein.
Protein: COBT_SALAR
Sequence: MQTLHALLRDIPAPDTDAMARAQQHIDGLLKPPGSLGRLEALAVQLAGMPGLNGTPQVGEKAMLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAEPIPGVVNMRVARGCGNIAVGPAMSRSQAEVLLLEVIRYTCDLAQRGVTLFGVGELGMANTTPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPDPHDGIDVLSKVGGFDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRSYLIPSHFSAEKGARIALAHLAMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLPGEKQT
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: S22A6_RABIT
Sequence: MAFNDLLKQVGGVGRFQRIQVTLVVLPLLLMASHNTLQNFTAAIPPHHCRPPAHANLSKDGGLQAWLPQDTQGRPKSCLRFTSPQERPPFLNGTEANGTGTTEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLGQSLYMAGVLIGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFSPNFTVYCTFRLLSGMSLAGIALNCMTLNVEWMPIHTRAYVGTLAGYVYSTGQFLLAGVAYAVPHWRYLQLLVSVPFFAFFVYSWFFIESARWYSTPGRLDLTLKALQKVARINGKQEEGAKLSMEVLRTNLQKELTMSKGQASAMELLRCPALRHLFLCLSLLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVCFLVINSLGRRPAQMASLLLAGICILVNGVIPRDQSIVRTSLAVLGKGCLASSFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLVSMTSELYPSLPLFIYGAVPVAASAATALLPETLGQPLPDTVQDLESRRRGKPRRQQQEQQKQMVPLQASVQEKNGL
What is the function of this protein?
Involved in the renal elimination of endogenous and exogenous organic anions.  Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc).  Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (By similarity).  May contribute to the transport of organic compounds in testes across the blood-testis-barrier (By similarity).  Also mediates the sodium-independent uptake of cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS), 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate (By similarity).  Mediates the sodium-independent uptake of p-aminohippurate (PAH) and 2,3-dimercapto-1-propanesulfonic acid (DMPS).  PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red and glutarate (By similarity).  PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), urate, alpha-ketoglutarate and probenecid.
What are the official names of this protein?
Solute carrier family 22 member 6, Organic anion transporter 1, Renal organic anion transporter 1, rbROAT1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.