PharMolix/UniProtQA huggingface dataset:
Protein: SYFA_BACAA
Sequence: MEARLKELKQKALELIEEAKELKGLNDVRVAYLGKKGPITEVLRGMGKLSAEERPRMGALVNEVREAIQTRLDDKISNLEKAVIEAKLATETIDVTLPGRPVETGCHHPLTAVVEQIEDVFIGMGYEVAEGTEVEKDYYNFEALNLPKDHPARDMQDTFYITEETLLRTHTSSVQARTMENNKEKGPIKIICPGKVYRRDDDDATHSHQFMQIEGLVIDKNIRMSDLKGTLQVFVKKMFGEDREIRLRPSFFPFTEPSVEMDISCMMCHGKGCGTCKGTGWIEILGAGMVHPNVLEMAGYDSKEYQGFAFGMGAERIAMLKYGVDDIRHFYTNDVRFLQQFKRA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSXE_ECOSE
Sequence: MSEIKDVIVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTISTLRHWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPALSALDGFSIGMGATCAMFVLGSLREIIGNGTLFDGADALLGSWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAGKYLIDERMKKRRAEATAERALPNGETGNV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AR6P1_HUMAN
Sequence: MAEGDNRSTNLLAAETASLEEQLQGWGEVMLMADKVLRWERAWFPPAIMGVVSLVFLIIYYLDPSVLSGVSCFVMFLCLADYLVPILAPRIFGSNKWTTEQQQRFHEICSNLVKTRRRAVGWWKRLFTLKEEKPKMYFMTMIVSLAAVAWVGQQVHNLLLTYLIVTSLLLLPGLNQHGIILKYIGMAKREINKLLKQKEKKNE
What is the function of this protein?
Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner.  Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity).  Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037).  Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9).  Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298).  May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579).
What are the official names of this protein?
ADP-ribosylation factor-like protein 6-interacting protein 1, ARL-6-interacting protein 1, Aip-1, Apoptotic regulator in the membrane of the endoplasmic reticulum.
What is the protein family that this protein belongs to?
Belongs to the ARL6ip family.
Protein: PYRF_HAEIN
Sequence: MTSKIIVALDFEKEAEALALVDQIDPSLCRLKVGKEMFTTLGINFVKQLHQRNFDVFLDLKYHDIPNTVARAVRSAADLGVWMVDLHASGGLRMMEDAKKILEPYGKDAPLLIAVTVLTSMEDLDLLQIGINASPMEQVLRLAHLTQRAGLDGVVCSPQEVEILRNACGEDFKLVTPGIRPIGTDFGDQRRVMTPTAAIRAGSDYLVIGRPITQADNPAEVLRSINVSIG
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: YJ23_SCHPO
Sequence: MSLLRIRKASLYGFSTVFILLQSYAVAYPLRAFRQNDGIGIAMNPSQDGGFVSAEKDSDFEYWMKLIISAVLILLGGVFAGLTIGLMGCDDLHLQVLEQSGDASERVHARKVLKLLRRGKHWVLVTLLLGNVIVNETLPIVFDSIIGGGWPAVLISTAMIVIFGEVIPQATCVRYGLSIGAKLEPIVLFMMYLLWPIAYPTALILDACLGESQSTMYKKSGLKTLVTLHRDLGIDKLNQDEVTIITAVLDLREKHAESIMTPIEDVFTLPMDRILDEDLIGEIICAGYSRIPVHKPGFPHDFIGMLLTKTLIGYDPDDKWPVGKFALATLPQTWPNTSCLDLLNYCQEGKSHMILISNSPGEPHGAIGVITLEDIIEELIGEEIIDETDVYIDVHKGLPRVGENNDFWNRMLHRSHLSTMAALHKSQRSHDLAANEHAPILNPKNSALNPRLVTNDRVKVKSPSLIQSSTGYGSMSQSPSRSDLPSKISRVNAELQAHGSQRSSIDVSKENKSSVADGPSSQAHNGPSTQPPEALPNGTDPSSSKTTENNGNQQSERTESADGKKDNSGSISSNSSKTFTGKRVRLGNVIESNVVSPDGTNRIVIEPFERSVDPNNADIVEMVERNGIVVPKVTVTSHEDDVDSVHNTPMSVSSTLSVKTSSSKVPRNKRKRRKGKSKK
What are the official names of this protein?
Uncharacterized protein C4B3.03c.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FRMD6_MOUSE
Sequence: MNKLTFHNNKAMQDRRRVCIFLPNDKSVSIIINVKILCHQLLVQVCDLLRLKDSHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGKLISDRIARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRKLHHGDYFEPEAYFPAWVVSKRGKDYILKHIPNMHKDQFALTASEAYLKYIKEAVRLDDVAIHYYRLYKDKREAEGSLTLGLTMRGIQIFQNLEEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLVYYTGCPTRSRHLLQLLSNSHRLYMNLQPVLRHLRKQEENEEKKQYRESYISDNLDLDMDPLEKRSRASGSSAGSVKHKRLSRHSTASHSSSHTSGIEADTKPRDPGPEDSCSGSAMHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDSQDEEIEMLVDDPRDLEPMPEESLEVSPEMCIYITEDMLLSRKLNGHSGLIVKEIGSSTSSSSETVVRLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDESGLYCNSCLAQQCVNIQDAFPVKRASKYFSLDLTHDEVPEFVV
What are the official names of this protein?
FERM domain-containing protein 6.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Can colocalize with actin.
Protein: CTHR1_MOUSE
Sequence: MHPQGRAAPPQLLLGLFLVLLLLLQLSAPISASENPKVKQKALIRQREVVDLYNGMCLQGPAGVPGRDGSPGANGIPGTPGIPGRDGFKGEKGECLRESFEESWTPNYKQCSWSSLNYGIDLGKIAECTFTKMRSNSALRVLFSGSLRLKCRNACCQRWYFTFNGAECSGPLPIEAIIYLDQGSPELNSTINIHRTSSVEGLCEGIGAGLVDVAIWVGTCSDYPKGDASTGWNSVSRIIIEELPK
What is the function of this protein?
May act as a negative regulator of collagen matrix deposition.
What are the official names of this protein?
Collagen triple helix repeat-containing protein 1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: COAE_STRA5
Sequence: MTKIIGLTGGIASGKSTVTKIIRESGFKVIDADQVVHKLQAKGGKLYQALLEWLGPEILDADGELDRPKLSQMIFANPDNMKTSARLQNSIIRQELACQRDQLKQTEEIFFMDIPLLIEEKYIKWFDEIWLVFVDKEKQLQRLMARNNYSREEAELRLSHQMPLTDKKSFASLIIDNNGDLITLKEQILDALQRL
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2594_NITOC
Sequence: MKGGLGNLMKQAQQLQSNMEKAQEELANMEVTGQAGGGMVSIVMTGRYDCRRISIHSELWQEDKEMVEDLVAAAINDAVRQVETQSKEKMSSMTSGMLPPGFKLPL
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Noc_2594.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DELE1_HUMAN
Sequence: MWRLPGLLGRALPRTLGPSLWRVTPKSTSPDGPQTTSSTLLVPVPNLDRSGPHGPGTSGGPRSHGWKDAFQWMSSRVSPNTLWDAISWGTLAVLALQLARQIHFQASLPAGPQRVEHCSWHSPLDRFFSSPLWHPCSSLRQHILPSPDGPAPRHTGLREPRLGQEEASAQPRNFSHNSLRGARPQDPSEEGPGDFGFLHASSSIESEAKPAQPQPTGEKEQDKSKTLSLEEAVTSIQQLFQLSVSIAFNFLGTENMKSGDHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGHSLAQYRYARCLLRDPASSWNPERQRAVSLLKQAADSGLREAQAFLGVLFTKEPYLDEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALRCYQQSAALGNEAAQERLRALFSMGAAAPGPSDLTVTGLKSFSSPSLCSLNTLLAGTSRLPHASSTGNLGLLCRSGHLGASLEASSRAIPPHPYPLERSVVRLGFG
What is the function of this protein?
Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707).  It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707).
What are the official names of this protein?
DAP3-binding cell death enhancer 1, DAP3-binding cell death enhancer 1, long form, DELE1(L), Death ligand signal enhancer.
What is the protein family that this protein belongs to?
Belongs to the DELE1 family.
What are the subcellular locations of this protein?
[DAP3-binding cell death enhancer 1]: Mitochondrion. Mitochondrion inner membrane. Note=Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1). SUBCELLULAR LOCATION: [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol. Note=This short form is generated by proteolytic processing by OMA1 in response to mitochondrial stress, leading to translocation to the cytosol.
Protein: MUTS_STAAU
Sequence: MSNVTPMMQQYLKIKSEYQDCLLFFRLGDFYEMFYEDAKEASRVLEITLTKRDAKKENPIPMCGVPYHSADSYIDTLVNNGYKVAICEQMEDPKQTKGMVRREVVRIVTPGTVMEQGGVDDKQNNYILSFVMNQPEIALSYCDVSTGELKVTHFNDEATLLNEITTINPNEVVINDNISDNLKRQINMVTETITVRETLSSEIYSVNQTEHKLMYQATQLLLDYIHHTQKRDLSHIEDVVQYAAIDYMKMDFYAKRNLELTESIRLKSKKGTLLWLMDETKTPMGARRLKQWIDRPLISKEQIEARLDIVDEFSAHFIERDTLRTYLNQVYDIERLVGRVSYGNVNARDLIQLKHSISEIPNIKALLNSMNQNTLVQVNQLEPLDDLLDILEQSLVEEPPISVKDGGLFKVGFNTQLDEYLEASKNGKTWLAELQAKERQRTGIKSLKISFNKVFGYFIEITRANLQNFEPSEFGYMRKQTLSNAERFITDELKEKEDIILGAEDKAIELEYQLFVQLREEVKKYTERLQQQAKIISELDCLQSFAEIAQKYNYTRPSFSENKTLELVESRHPVVERVMDYNDYVPNNCRLDNETFIYLITGPNMSGKSTYMRQVAIISIMAQMGAYVPCKEAVLPIFDQIFTRIGAADDLVSGKSTFMVEMLEAQKALTYATEDSLIIFDEIGRGTSTYDGLALAQAMIEYVAETSHAKTLFSTHYHELTTLDQALPSLKNVHVAANEYKGELIFLHKVKDGAVDDSYGIQVAKLADLPEKVISRAQVILSEFEASAGKKSSISNLKMVENEPEINQENLNLSVEETTDTLSQKDFEQASFDLFENDQESEIELQIKNLNLSNMTPIEALVKLSELQNQLK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: TMM94_MOUSE
Sequence: MDLREKHLGEPPLALGLSTRKALSVLKEQLEAVLEKHLKERKKSLTWKEAWRSSFLHLSNRCSCFHWPGASLMLLAVLLLLCCCGGQPAGSQGVELVNASALFLLLLLNLVLIGRQDRLKRREVERRLRGIIDQIQDALRDGKEIKWPNSMYPDLHMPFAPSWSLHWAYRDGHLVNLPVSLLVEGDIIALRPGQESFASLRGIKDDEHIVLEPGDLFPPFSPPPSPRGEVKRGPQNPQQHRLFRVLETPVIDNIRWCLDTALSRPVTALDNERFTVQSVMLHYAVPVVLAGFLITNALRFMFKAPGVTSWQYTLLQLQVNGMLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAKFSEDTLSSYTEAVSSQEMLRCIWGHFLRVIQGTSPTLSHSASLLHSLGSVTVLCCVDKQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDDLSTRSFCHPEVEEEPHEHDALLAGSLNNTLHLSNEQERSDWLADGPKPSEPYPHHKGHGRSKHPSGSNVSFSRDTEGGEEEPSKAQPGTEGDPYEAEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQSHLTSLKPLGLNVLLNLCNASVTERLCRFSDHLCNIALQESHSAVLPVHVPWGLCELARLIGFTPGAKELFKQENHLALYRLPSAETLKETSLGRPSCVTKRRPPLSHMISLFIKDTATSTEQMLSHGSADVVVEACTDFWDGADIYPLSGSDRKKVLDFYQRACLSGYCSAFAYKPMNCTLSSQLNGKCIELVQVPGQNSIFTMCELPSTIPIKPNNRRSSWSSDEGIGEVLEKEDCMQALSGQIFMGMVSSQYQARLDIVRLIDGLVNACIRFVYFSLEDELRSKVFAEKMGLETGWNCHISLTPNGDMPGSEIPPSSPSHAGSLHDDLNQVSRDDAEGLLLLEEEGHSDLISFQPTDSDIPSFLEDCNRAKLPRGIHQVRPHLQNIDNVPLLVPLFTDCTPDTMCEMIKIMQEYGEVTCCLGSSANLRNSCLFLQSDVSIALDPLYPSRCSWETFGYATSTTMAQASDGLSPLQLSGQLNSLPCSLTFRQEESISIIRLIEQARHATYGIRKCFLFLLQCQLTLVVIQFLSCLVQLPPLLSTTDILWLSCFCYPLLSISLLGKPPHSSIMSMATGKNLQSIPKKTQHYFLLCFLLKFSLTISSCLVCFGFTLQSFCDSARARNLTNCSSVMLCSNDDRAPAWFEDFANGLLSAQKLTAALIVLHTVFISITHVHRTKPLWRKSPLTNLWWAVTVPVVLLGQVVQTVVDLQLWTHRDSRVHFGLEDVPLLTWLLGCLSLVLVVVTNEIVKLHEIRVRVRYQKRQKLQFETKLGMNSPF
What are the official names of this protein?
Transmembrane protein 94.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PEPE_SALA4
Sequence: MELLLLSNSTLPGKAWLEHALPLIANQLNGRRSAVFIPFAGVTQTWDEYTDKTAEVLAPLGINVTGIHRVADPLAAIEKAEIIIVGGGNTFQLLKESRERGLLAPMADRVKRGALYIGWSAGANLACPTIRTTNDMPIVDPNGFDALDLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTVIGLPEGNWIQVSNGQAVLGGPNTTWVFKAGEEAVALEAGHRF
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_BUCAI
Sequence: MKIRPLHDRVLVKRQEVESKSAGGIVLTGSAAGKSTRGTVTAVGKGRVLDNGDIKPLDVKVGDVVIFNEGYGAKTEKIDNEELLILTESDILAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANK_YERPG
Sequence: MGKGLALDIGGTKIAAAVVTESGMLIGRQQIATPRGGAGQLAAALETLIAPYRHQVDFIAVASTGIISGGRLTALNPANLGGLADFPLYDCIRSISDLPCVLLNDGQAAAWAEYQALGDKNDNMMFVTVSTGVGGGIILNKKLLVGQRGLAGHIGHTLSDPHGVLCGCGRRGCVESVASGTAIGAETLGWKQPVSAATVFDMAQQGDAQAGKVINRSAAAIAQMLADMKMALDLEVVILGGSVGLAVGYLERVVAAQKTLPGIYRVPVQEAHHRQDSGLLGAALWARTSL
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.
Protein: FUR_BRUME
Sequence: MNKPYTKPDYEQELRRAGVRITRPRRIILNILNETEDHPDALEIFRRAVEEDDSISLSTVYHTMKLLEERGAIHRHAFAGGPSRFEQASGAHHDHIIDMDSGDVVEFHSDKIEKLQEEIARSLGFEIVHHRLELYCKKLKS
What is the function of this protein?
Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
What are the official names of this protein?
Ferric uptake regulation protein, Ferric uptake regulator.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_ANAD2
Sequence: MMPTQRLAEADPQIAKLIREETRRQAEGLELIASENFVSPAVLEALGSTLTNKYAEGYPGKRYYGGCEVVDQVEQLAIDRAKQLFGADHANVQPHAGSQANMAAYFALAKPGDTVLAMSLNFGGHLTHGSPVNFSGKLFKIVPYGLRQSDETIDMDEVARLAREHKPRILMVGASAYSRTLHFDRFAEIANEVGAAMVVDMAHIAGLVAAGLHPSPVPHSEIVTTTTHKTLRGPRGGMILCREAHAKTLNSQIFPGIQGGPLEHVIAAKAVAFGEALRPEFKAYQRRIVENAQVLAEGLKSAGLRLVSGGTDNHLMLVDLRPKKLTGKIAEEALGKAGITVNKNMIPWDPEKPMTTSGIRVGTPALTTRGMGSREMTLVAALIGRVLDAPADEQVLARVRGEVKDLCAHFPMYADRV
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_COXBU
Sequence: MPKLKTNRGAVKRFKVTGSGKIKRAASNHNHILTKKSQKRKRRLRKIHEVAPSDMRAVSEMLRD
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: LDHA_LINNU
Sequence: MSTKEKLISHVMKEEPVGSRSKVTVVGVGMVGMASAISILLKDLCDELAMVDVMEDKLKGEVMDLQHGSLFLKTKIVGDKDYSVTANSKVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCILMVVSNPVDILTYVAWKLSGFPRHRVIGSGTNLDSARFRHLIGEKLHLHPSSCHAWIVGEHGDSSVPVWSGVNVAGVSLQGLNPQMGTEDDGENWKAIHKEVVDGAYEVIKLKGYTSWAIGMSVADLVESIIKNMHKVHPVSTLVQGMHGVKDEVFLSVPCVLGNSGLTDVIHMTLKAEEEKQLQKSAETLWGVQKELTL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP8B1_RABIT
Sequence: MVLWGLLGALLMVMVGWLCLPGLLRQRRPQEPPLDKGSIPWLGHAMTFRKNMLEFLKHMRSKHGDVFTVQLGGQYFTFVMDPVSFGPILKDGQRKLDFVEYAKGLVLKVFGYQSIEGDHRMIHLASTKHLMGHGLEELNKAMLDSLSLVMLGPEGRSPDASRWHEDGLFHFCYGVMFKAGYLSLFGHTSDKRQDLLQAEEIFIKFRRFDLLFPRFVYSLLGPREWREVGRLQQLFHELLSVKHNPEKDGMSNWIGHMLQYLSEQGVAPAMQDKFNFMMLWASQGNTGPASFWALIYLLKHPEAMRAVKEEATRVLGEPRLEAKQSFTVQLSALQHIPVLDSVMEETLRLGAAPTLYRVVQKDILLKMASGQECLLRQGDIVTLFPYLSVHMDPDIHPEPTTFKYDRFLNPNGSRKVDFYKAGQKIHHYTMPWGSGVSICPGRFFALSEMKLFVLLMVQYFDLELVDPNTPVPPIDPRRWGFGTMQPTHDVRIRYRLKPLE
What is the function of this protein?
A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis.  Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:1400444, PubMed:8943286).  Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (PubMed:1400444, PubMed:8943286).
What are the official names of this protein?
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase, CYPVIIIB1, Cytochrome P450 8B1, Sterol 12-alpha-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single- pass membrane protein.
Protein: MTOX_YERPB
Sequence: MDYDLIVIGSGSVGSAAGYYASQAGLNVLMIDSAMPPHQAGSHHGETRIMRHAYGEGEKYVPLVLRAQALWDQLAAQTGEKLFQACGVINLGPDNSTFLQNVQRSAQQYDLPVETLNSTQIREKWPVFTVPDNYIAVFEPQSGYLRSELAVKTLIKAVTEAGCGILFNCPVTAIESHQAGVDVVTIDGTYSATKVVVTAGTWVKELLPTLPVTPVRKVFSWHQADGRYSEANHFPAFTVEMPDNILYYGFPAQNDALKLGKHHGGQLIESAAQRKPFGRYAEDGTEVFSFLRHFLPGVGVCLRGEACSYDMSPDEDFIIDTLPEDERVMVVSGLSGHGFKFATALGEVAALFAQDKPSPIDISAFSLARFR
What is the function of this protein?
Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.
What are the official names of this protein?
N-methyl-L-tryptophan oxidase, MTOX.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family. MTOX subfamily.
Protein: RIFK_PICGU
Sequence: MTSRPETKIPDEITSPYPIIGAGTIESGFGRGSAELGIPTANIPVTSELNKLETGIYYGWCRLVPRNQECAAKQRSDGKKVYFNNGTKLADDELETFPMAMSIGWNPFYNNETKTAEVHIIHKFRENFYGADLRYAVMGHIRPELNYTTKEALIADINKDIEITKDALSKPSYEKYRTKI
What is the function of this protein?
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
What are the official names of this protein?
Riboflavin kinase, Flavin mononucleotide kinase 1.
What is the protein family that this protein belongs to?
Belongs to the flavokinase family.
Protein: DNAJ_ACEP3
Sequence: MATQLDYYAILEVSRTATADELKKSYRKLAMKYHPDRNPGDDAAEAKFKEINQAYDILKDEQKRAAYDQYGHAAFEGGGPGPGGFDFGGGFGGGGLGDIFEQMFGDMMGGRRGGRARTGNDIQTHVEITLEEAFSGVKKDVRVITRVACEACHGTGSDDGASGVEVCPSCHGAGKVRAQQGFFVVERPCPTCHGAGKVVKNPCKVCHGEGTVEKERTVEVQIPAGVEDGTRIRLSGEGEAGGNGVPPGDLYIHVSVTEHGIFQRDGANIYCRVPLRMAQAALGTEIEVPVIDGSRTKVKIPAGTQTGAHFRLRGKGFSVLRSTARGDMYIQVTVETPQNLSKRQRELLEEFEKEAGEDVKQSPEHTGFFRRVRDFFEGKE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_ACTPJ
Sequence: MTPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGHANIAGYNFIVIDTGGIDGTEEGVEEKMAEQSLLAIEEADVVLFLVDARAGLVPADIGIAQYLRQREKTTVVVANKTDGIDADSHCAEFYQLGLGEVEQIAAAQGRGVTQLIDQVLAPLGEQLNADQAVENEENSANEEADEWDTDFDFENEDDTALLDEALEEETEESIEDKNIKIAIVGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERDGQQYTIIDTAGVRKRGKVNLAVEKFSVIKTLQAIQDANVVLLTIDAREGISDQDLSLLGFILNAGRSLVIVVNKWDGLSQDIKDQVKSELDRRLDFIDFARVHFISALHGSGVGNLFDSVKEAYACATQKTSTSMLTRILRMAADEHQPPLVNGRRVKLKYAHPGGYNPPIIVIHGNQVEKLADSYKRYLSNYFRKSLKIIGSPIRIQFQEGNNPFAGKKNKLTPSQLRKRKRLMKFIKKSKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: SPAST_DROMO
Sequence: MVRTKNQSSSSSASSSTKSPVKISGGGSSGANRSRSCSEALIDDGKTSSKLSSNRQRATITTTTTSTTPGSSPDDDTTDADLTPTSGYGPRGGTSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYCASTKVIYRSPHRRDCNIEIVVQNSKEQQSIICPLERNTSDGIEKAQQLLPQRQRALLPLEMATNRGGSGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHEKMQTNLSMARDRLHFLALREEDLQMQRLSLMDPPKNKQQVTSKFKQPMLVGQTNSKAAAVEPSKITMRSSGYGPKPVSGTGSSAGTSKALQAASGRKLTIGNKRPGNLAVANKSQTLPRNLGSKTTSTSVGAALQRQPGKTAATPPAVRRQFSSGRNTPPQRSRTPINNNAASGSGSGSGASTPMISVKGVEQKLVQLIMDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHLQPSIIFIDEVDSLLSERSSNEHEASRRLKTEFLVEFDGLPGNPEGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPEVQTRELLLSRLLQKQGSPLDTEALARLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRPITEKDFHNSLKRIRRSVAPQSLNSYEKWSQDYGDITI
What is the function of this protein?
ATP-dependent microtubule severing protein.  Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle.  Regulates microtubule stability in the neuromuscular junction synapse.  Involved in lipid metabolism by regulating the size and distribution of lipid droplets.  Involved in axon regeneration by regulating microtubule severing.
What are the official names of this protein?
Spastin.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Spastin subfamily.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Chromosome. Lipid droplet. Note=Forms an intramembrane hairpin-like structure in the membrane. Colocalizes with cellular microtubule arrays. Localizes to chromosomes from prometaphase/metaphase to anaphase, and this requires microtubules. Localizes to discrete punctate cytoplasmic foci which may correspond to secretory vesicles.