PharMolix/UniProtQA huggingface dataset:
Protein: TSAD_CELJU
Sequence: MRVLGLETSCDETGVAVYDSAQGLLAHRLYSQVKLHAEYGGVVPELASRDHVRKLLPLIDEVMAASGSTAADIDAIAYTAGPGLIGALMVGAAFGRSLAYAWGIPAVGVHHMEGHLLAPMLEAVPPEFPFVALLVSGGHTQLVKVMAIGDYELLGESIDDAAGEAFDKAAKMLDLDYPGGPQIARLAEQGVHGRFKFPRPMVDRPGLAFSFSGLKTATLTAVNAHKQANGLPDDQTCADIACAFQEAVVDTLVIKCRRALEQTGMKTLVIAGGVSANKKLRADLEVELARIGARVFYARHEFCTDNGAMIAYAGCQRLLAGQQEGLAIHVKARWPLNSLSSL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_BRUC2
Sequence: MYNYLDFEKPVADLEGQILELKKLAQEQGSVEMGDEISRLEKRSADALKDIYRKLTPWQKAQIARHPDRPHCLEYIDRLFTEFTPLAGDRKFANDEALQAGFGRFNGTPVAIIGQEKGSDTKTRLKHNFGSARPEGYRKAVRIMEMADRFQLPLITFVDTAGAYPGVSAEERGQAEAIARSTAECLKLRVPVISIIIGEGGSGGAIAIAVANRVYMLEHSIYSVISPEGAASILWHDSTRAKDAASDMRITAQDLFDLKIIDGIIPEPLGGAHRGKESVIDATGDIIAASLRSMKDIDGETLKQERRQKFLEIGRNI
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_RAT
Sequence: MAPVKKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEEPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL22 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDPA_PSE14
Sequence: MPIRHCIVHLIDKKPDGTPAVLHARDSELAESAAIENLLADLNDSYNAKQGKAWGFFHAESGAYPFSGWLKEYFDGSQDFTSFSRVAIKHLQTLMEASNLSTGGHVLFAHYQQGMTEYLAIALLHHSEGVAVNAELDVTPSRHLDLGQLHLAARINLSEWKNNQNSKQYISFIKGKNGKKVSEYFRDFIGCQEGVDGPGETRTLLKAFSDYVEKEDLPEESAREKTQTLVDYATAQTKLGEPVTLEELSSLIDEDRPKAFYDHIRNSDYGLSPEIPADKRTLNQFRRFTGRAEGLSISFEAHLLGEKIEYDEAAGTLIIKGLPTQLIDQLKRR
What are the official names of this protein?
Nucleoid-associated protein PSPPH_1145.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: Y555_AQUAE
Sequence: MSSFASFLDMWRDLDKYLSSLTIFNIQSSFMRIFLLFLFFVLFTFGVEGYVIEEINGSTGLRIHKEIKRKVYITEDALITETEKEFMVQKIENGLPRIYRVIKSSKSYMDFSKMTPLFLVSLPFLDCKQRVCVVNRGAFRPTNEYKKIRGFKARKVVVESHALGKKTTLIQWYTKEWKELVEANRLEDKFYVNFIRAIMKEKNLSEANIPLKEIQNFLKEINEKFGGVVRTQQQMPLFNTYSEVISVKKTEIPDYIYKLPEGYTKIK
What are the official names of this protein?
Uncharacterized protein aq_555.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ERA_CAMFF
Sequence: MKSGFISLIGRTNAGKSSLLNYLLNEKISMVSHKQNATRRKINGIVMHKDSQAIFIDTPGLHESNKTMNKLMVEAAIKSIGDCDLLLFVASVFDNIENYKKFLNLKKDAPHLIAITKIDEASDKEIFAKLNEYQIYSDEFKAIIPLSVKKQAYKNILLDEIYKYLPEHEYFYDPQYLTTANEREIFRDFILEAVYECVSDEVPYSTDVNVDKVVEKQNITEIYATIITDNEHHKAILIGKNGQTIKRIGINARKIINTLLNNKIFLKINVKIDKNWNSNESIIKKNFLY
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: HDOX_LISW6
Sequence: MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVVVTSKWESEEAQRNWVKSDSFKKAHGRTKDTREQREDRKGIVGNEIARFEVVHVQNPVTIEK
What is the function of this protein?
Allows bacterial pathogens to use the host heme as an iron source.  Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
What are the official names of this protein?
Heme-degrading monooxygenase, Heme oxygenase, Iron-regulated surface determinant, Iron-responsive surface determinant.
What is the protein family that this protein belongs to?
Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_BURM7
Sequence: MTTGFLQKIFGSRNQRLVKQYQKTVAAINALETQIETLTDDQLRGKTGEFRQRIAAGESLDKLLPEAFAVCREASRRVLKMRHFDVQMIGGMVLHYGKIAEMRTGEGKTLVATLAAYLNALAGRGVHVVTVNDYLAQRDAEWMGRLYNFLGLSVGINLSGMEHDQKQAAYAADITYGTNNEFGFDYLRDNMVYETDSRVQRPLNFAVVDEVDSILIDEARTPLIISGQAEDHTELYVRMNALPPLLERQIGEEKADGTGVEKPGDYTLDEKGRQVFLTESGHEKAERMLAEWGLIGDGESLYAPQNITLMHHVYAALRAHTLFHRDQHYVVQNDEVIIVDEFTGRLMPGRRWSDGLHQAVEAKEHVKIQSENQTLASITFQNYFRMYAKLSGMTGTADTEAYEFNEIYGLETVVIPTNRPPKRIDKQDQIYKTAKERYDAVIRDIRECHERGQPVLVGTTSIENSELLSHLLKQAGLPHEVLNAKQHAREAAIVAEAGRPKRITIATNMAGRGTDIVLGGNVEKQAAFIEADESIPADEKARRIQQLHDEWETLHEQVKTAGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDPLLRIFAGDRVRAIMDRLKMPEGEAIEAGIVTRSIESAQRKVEARNFDIRKQLLEYDDVSNDQRKVIYQQRNELLEAHDIAETIGAMRHGVISEVVRQFVPAGSIEEQWDLPELEETLRNDWQLDLAIQEMVNESSSINADEILDAVTTAADEHYEAKVALVGRESFSAFERSIMLQTLDRLWREHLAALDHLRQGIHLRGYAQKNPKQEYKREAFELFAAMLDAVKQEVTRIVMNVQIQSPEQLEEAAEQIEEQGGQLGNVEFQHADFAAAAAAATAGGAVVADATAEMVGHAMSHSGPAGEVPRVGRNDPCPCGSGKKYKHCHGKLN
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PRIB_ECOLI
Sequence: MTNRLVLSGTVCRAPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSRITVQGFISCHKAKNGLSKMVLHAEQIELIDSGD
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).  During primosome assembly it facilitates the complex formation between PriA and DnaT.
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: ASNA_DROAN
Sequence: MGDNLEPLEPSLQNLVEQDSLKWIFVGGKGGVGKTTCSSSLAVQLAKVRESVLIISTDPAHNISDAFDQKFTKVPTKVNGFDNLFAMEIDPNAGLNELPEEYFEGENEALRVSKGVMQEMINALPGIDEAMSYAEVMKLVKGMNFSVVVFDTAPTGHTLRLIAFPQVVEKGLGKLLRLKMKVAPMLTQFVSMLGMADVNADTLSQKLDDMLRIITQVNEQFKNPDQTTFVCVCIAEFFSLYETERLVQELTKCGIDVHNIIVNQLLFLQNSHDSCSMCASRYKIQEKYLDQIADLYEDFHVTKLPLLEKEVRGPESIRSFSENLMTPYEPKAKPKE
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase ASNA1 homolog, Arsenical pump-driving ATPase homolog, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: NKAP_RAT
Sequence: MAPVSGSRSPVREASGGKRRSSSRSPKSIKSSRSPRCRRSRSRSCSRFGDRNGLSHSLSGFSQSSRNQSYRSRSRSRSRERPSAQRSAPFASSSSSAYYGGYSRPYGGDKPWPSLLDKEREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTSASSSEDDKKKKRKSSRSKERAKKKRKKKSSKRKHKKYSEDSDSDSESDTDSSDEDSKRRAKKAKKKEKKKKRRGKKYKKKKSKKNRKESSDSSSKESQEEFLENPWKDRSKTEEPSDLIGPEAPKTLASQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKDDK
What is the function of this protein?
Acts as a transcriptional repressor.  Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development.  Also involved in the TNF and IL-1 induced NF-kappa-B activation.  Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity).
What are the official names of this protein?
NF-kappa-B-activating protein.
What is the protein family that this protein belongs to?
Belongs to the NKAP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS10_LACAC
Sequence: MASQTIRIRLKSYEHGILDESAAKIVATAKRTGAEISGPVPLPTERTLFTVLRSPHKNKDSREQFEMRTHKRLIDILNPTPKTVDSLMKLDLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: HPRT_SALTY
Sequence: MKHTVEVMIPEAEIKARIAELGRQITERYKDSGSEMVLVGLLRGSFMFMADLCREVQVPHEVDFMTASSYGSGMSTTRDVKILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILGLREPKSLAICTLLDKPSRREVDVPVEFVGFSIPDEFVVGYGIDYAQRYRHLPYVGKVVLLDE
What is the function of this protein?
Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate).  To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.
What are the official names of this protein?
Hypoxanthine phosphoribosyltransferase, HPRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORC1_YEAST
Sequence: MAKTLKDLQGWEIITTDEQGNIIDGGQKRLRRRGAKTEHYLKRSSDGIKLGRGDSVVMHNEAAGTYSVYMIQELRLNTLNNVVELWALTYLRWFEVNPLAHYRQFNPDANILNRPLNYYNKLFSETANKNELYLTAELAELQLFNFIRVANVMDGSKWEVLKGNVDPERDFTVRYICEPTGEKFVDINIEDVKAYIKKVEPREAQEYLKDLTLPSKKKEIKRGPQKKDKATQTAQISDAETRATDITDNEDGNEDESSDYESPSDIDVSEDMDSGEISADELEEEEDEEEDEDEEEKEARHTNSPRKRGRKIKLGKDDIDASVQPPPKKRGRKPKDPSKPRQMLLISSCRANNTPVIRKFTKKNVARAKKKYTPFSKRFKSIAAIPDLTSLPEFYGNSSELMASRFENKLKTTQKHQIVETIFSKVKKQLNSSYVKEEILKSANFQDYLPARENEFASIYLSAYSAIESDSATTIYVAGTPGVGKTLTVREVVKELLSSSAQREIPDFLYVEINGLKMVKPTDCYETLWNKVSGERLTWAASMESLEFYFKRVPKNKKKTIVVLLDELDAMVTKSQDIMYNFFNWTTYENAKLIVIAVANTMDLPERQLGNKITSRIGFTRIMFTGYTHEELKNIIDLRLKGLNDSFFYVDTKTGNAILIDAAGNDTTVKQTLPEDVRKVRLRMSADAIEIASRKVASVSGDARRALKVCKRAAEIAEKHYMAKHGYGYDGKTVIEDENEEQIYDDEDKDLIESNKAKDDNDDDDDNDGVQTVHITHVMKALNETLNSHVITFMTRLSFTAKLFIYALLNLMKKNGSQEQELGDIVDEIKLLIEVNGSNKFVMEIAKTLFQQGSDNISEQLRIISWDFVLNQLLDAGILFKQTMKNDRICCVKLNISVEEAKRAMNEDETLRNL
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  It has a role in both chromosomal replication and mating type transcriptional silencing.  Binds to the ARS consensus sequence (ACS) of origins of replication.
What are the official names of this protein?
Origin recognition complex subunit 1, Origin recognition complex 120 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the ORC1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIGB_PECAS
Sequence: MWLRNSVFLIIIVVGGIGGFPAVAAVCPDWDNTRASKEIDALRQQLEQWDDVYYTEGKSPIEDDVYDQLREQLNQWSQCFQPQNVIPARLPDNGKQPHPVAHTGLKKLSDRVQLVQWIVQREDLWVQPKVDGVAVTLVYQHGKLVSAVSRGNGLQGEDWTEKARLIPDIPHLLSGAPSSFVLQGELFLKMTDHRQYAQGGVNARSIVAGEMRRHQPSPVLSQIGLFVWEWPDGPKAMPERLDKLKEMGFAMTADYTHAIESFADVEKWRDHWYHSPLPFVTDGVVIRQTKEPQGRYWRNTSADWAIAWKYPPVHQVAEVVDVAFSVGRTGKVAVVLKISPLKLDDKSVSRVNVGSLSRWKQWDVLPGDRVSVSLAGQGIPRLDNVVWRGTERPVIVSPDEHNFHAFSCFRYSVVCQQQFLARLVWLSGEHGLNLAGMRDGMWLRLMQHDLLGDVLSWLYLTEAQLNAVNGMGDKRARDIYMSLQSARQKSLSHWLLALGIPVPRSAISALNNVNWLALQQRTAQQWRQFSGIGERRAEEIMAFLNHPIVMELIARLDLEGIHR
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Protein: URE2_CUPMC
Sequence: MIPGELMPLDGEIELNAGRPTVTVTVANTGDRPVQVGSHFHFYETNAALSFDREAARGYRLDIAAGTAVRFEPGQSRTVQLVALDGDRIVYGFNGRIMGAL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_GEOKA
Sequence: MGEAEMNEDVYVLGIETSCDETAAAVVKNGREVLSNVVASQMESHRRFGGVVPEIASRHHVEQITLVIEEAMQQAGVSFASLDAVAVTAGPGLVGALLVGVNAAKALAFAHGLPLIGVHHIAGHIYANQLVAEMKFPLLALVVSGGHTELVFMKEHGNFAVIGETRDDAAGEAYDKVARALGLPYPGGPHIDRLAHEGEPVIDLPRAWLEEGSYDFSFSGLKSAVLNALHNAKQRGEEIDPRQMAASFQASVVDVLVTKTVQAAKEYRVRQVLLAGGVAANRGLRAALQDKMKELPDVELVIPPLSLCTDNAAMIAVAGTVLYQQGKRADLALNANPSLPLV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN181_RAT
Sequence: MASYFDEHDCEPLNPEREARNNMLLELARRVRGAWSWAPGSRSLFNRMDFEDLGLVDWEHHLPPPAAKAVVESLPRTVIRSSKAELKCPVCLLEFEEEETVIEMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDSYEEHKKDKARRQQQQHRLENLHGAMYT
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF181, RING finger protein 181.
What is the protein family that this protein belongs to?
Belongs to the RNF181 family.
Protein: SYP_CLOP1
Sequence: MKMSNMLVGTLREVPAEAEIESHKLMLRAGLMRKMAAGIYNYMPLGLKVIENVKNIVREEMNNAGAQEFLASALIPAELWQESGRWDAYGAEMFRLKDRHNRDFCLGPTHEEVFTDIVRNEIKSYKQLPLNLYQIQTKYRDERRPRFGVMRSREFIMKDGYSFDKDQEGLDLAYEKMRKAYVNIFNRCGLDAKAVAADSGAIGGSGSAEFMVKSEVGEDDVVFCTACDYAANIEKAPSTPEHAEKEELMEVEKVETPAVKSIEDLAKFFECSPKKIAKTLIFQADDKVVAVVLRGDREANEVKIANAIGEVIELEMASEEAVKEATGAAVGFAGPMGIKVDMLLVDQEVANMYNFIIGANETDMHLKNVNYGRDFEGIVGDFRNVTIGEKCPECGKEITISRGTEVGHIFKLGTKYSESMGATFIDEDGKAKPFIMGCYGIGVTRTVASIIEQHNDENGIIWPLEVAPYHVSVIPANVKNEEQATKAEEIYNELRKMGVEALLDDRKERAGVKFKDSELMGIPMRITVGKMIGEGQVEFKLRNGGEVETLSIEEVYNRVREEFERANLSL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_VIBC3
Sequence: MFEKPVVKTFQYGNHTVTLETGVMARQATAAVMATMDDTAVFVSVVGKKEAVVGQDFFPLTVNYQERTYAAGKIPGGFFKREGRPSEGETLIARLIDRPIRPLFPDGFTNEVQVIATVVSVNPDVQPDIISMIGTSAALAISGLPFNGPIGAARVGHIDGQLVLNPSEKELKQSRLDLVVAGTDNAVLMVESEAQILTEEEMLAAVVFGHDQQQAVIKAINEFAAEVATPAWEWVAPAENTELKAKVAALAETRLVEAYQITEKMARYDRIHAISSEVTAALLAENEALDTKEIHTIFHDLEKTVVRRSIIAGNPRIDGREKDMVRALDVRTGVLPRTHGSALFTRGETQALVTATLGTQRDAQIIDELTGEKKDHFLLHYNFPPYCVGETGFVGSPKRREIGHGRLAKRGIAAVMPSPEEFPYTVRVVSEITESNGSSSMASVCGSSLALMDAGVPIKASVAGIAMGLVKEENDFVVLSDILGDEDHLGDMDFKVAGTATGVTALQMDIKIEGITKEIMQIALNQAKGARLHILSVMDQAISAARSDISEFAPRIHTMKISVEKIKDVIGKGGAVIRQLTEETGTTIEIEDDGTIKIAATDGDQAKEAIRRIQEITAEVEVGVIYTGKVARLADFGAFVTILPGKDGLVHISQIADKRVEKVSDYLTEGQEVQVKVLEIDRQGRVRLSMKEAVETSDAAAEVAPQAAPQAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSPO_BACCN
Sequence: MGKRKANHIVPGMNAASAQGQGTGYNEEFANEPLTAAQRQNNKKRKKNQ
What are the official names of this protein?
Small, acid-soluble spore protein O, SASP O.
What is the protein family that this protein belongs to?
Belongs to the SspO family.
What are the subcellular locations of this protein?
Spore core.
Protein: RUVB_ALIFM
Sequence: MIEADRLIAADNPTFREEDVIDRAIRPKKLDDYQGQDHVRGQMEIFIKAAQMREEALDHLLIFGPPGLGKTTLANIVANEMGVNIRTTSGPVLEKAGDLAALLTNLEENDILFIDEIHRLSPMVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEYYKVEDLQHIVQRSADCLNLSMESEGALEVARRARGTPRIANRLLRRVRDYAEVMSDGNISSDIADKALNMLDVDVRGFDYMDRKLLLAIMEKFDGGPVGLDNIAAAIGEERDTIEDVIEPYLIQQGYLQRTPRGRIVSDRAYLHFGIDKPDK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: TAF8_DANRE
Sequence: MADSVMMGSGSLNSGSRSGSSKTCTSPTENYQLARRRTLQVVVSALLTECGFDSAEKAVVETLTEMMQSYITEVGRCAKANCEHTARSTPTLSDVVITLVEMGFNVDTLPVYAKRSQRMVITAPPITNAPVVPKSLTAGQKRTHPAHIPSHFPDFPDPHTYIRTPTFREPVSDYQVVREKAASQRRDVERALTRFMAKTGETQSLFKDDISAFPLIAAKPSPIPYLSALLPSELELQSLEETDSSEQDDQMDNDNNTSHIMQDDSGADKENEVLPPGGVVPSGKANEENMIDNPYLRPVKKPKVRRKK
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.  TFIID recognizes and binds promoters with or without a TATA box via its subunit tbp, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC).  The TFIID complex consists of tbp and TBP-associated factors (TAFs).  Mediates both basal and activator-dependent transcription.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 8, Protein taube nuss-like, TBP-associated factor 8.
What is the protein family that this protein belongs to?
Belongs to the TAF8 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: PSF1_BOVIN
Sequence: MFCEKAMELVRELHRAAEGRLPAFNEDGLRQVLEEMKALYEQNQSDVNEAKSSGRGDLIPTIKFRHCSLLRNQRCTVAYLYDRLLRIRALRWEYGSVLPSALRFHMSAEEMDWFNRYKKSLATYMRSLGGDEGLDITQDMKPPKSLYIEVRCLKDYGEFEVEDGTSVLLKKNSQHFLPRWKCEQLIRQGILEHVLS
What is the function of this protein?
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks.  GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
What are the official names of this protein?
DNA replication complex GINS protein PSF1, GINS complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GINS1/PSF1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with chromatin.
Protein: ERD2B_ARATH
Sequence: MNIFRLAGDMTHLASVLVLLLKIHTIKSCAGVSLKTQELYAIVFATRYLDIFTSFVSLYNTSMKLVFLGSSFSIVWYMKYHKAVHRTYDREQDTFRHWFLVLPCFLLALLIHEKFTFLEVLWTSSLYLEAVAILPQLVLLQRTRNIDNLTGQYIFLLGGYRGLYILNWIYRYFTEPHFVHWITWIAGFVQTLLYADFFYYYFLSWKNNKKLQLPA
What is the function of this protein?
Determines the specificity of the luminal endoplasmic reticulum protein retention system.  Required for the retro-transport of calreticulin-3 (CRT3) from the Golgi to the ER.  Specifically required for elongation factor Tu receptor (EFR) function in response to the pathogen-associated molecular pattern (PAMP) elf18.
What are the official names of this protein?
ER lumen protein-retaining receptor B.
What is the protein family that this protein belongs to?
Belongs to the ERD2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.