PharMolix/UniProtQA huggingface dataset:
Protein: RBM46_XENTR
Sequence: MEDNCTDMFNGCSKFDISIQTQVALLALIDNTGYTMVQVNGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDKLVPLFARAGKIYEFRLMMEFSGENRGYAFVMYTNKEEALLAIRMLNNYEICQGKFIGVCVSLDNCRLFIGSIPQEKRKEEILEEMKKVTEGVMDVIVYPSATDKTKNRGFAFVMYESHRAAAMARRKLIPGPFQLWGHTIKVAWASPEKEVDEETMQKVKVLYVRNLMMSTTEETIKAEFNRYKPGVVERVKKIRDYAFVHFFRRDYAIAAMSVMNGRLIDGARIEVTLAKPVNKEAAWRQNGNGHMNANSECLLNFANKEGSQKALDMCSNVPAYLNNPNSPTFLEPETCTYPCIPGTKLTPINLYSLKIHHFHSAVMHLEYFCYKNNWSFPEYYLYSTTGQDGKMLLAYKVILPAITGNTNSYFMPDKLCSFVEDAKELAAQFTLMHLDYSYHPTSGKNISLPSTAATSGTSGVLPYTPKPYSYSSYPSSPNVSLTNGGSVGKQLYVSNQASYFSG
What are the official names of this protein?
Probable RNA-binding protein 46, RNA-binding motif protein 46.
Protein: PURA_MYCBT
Sequence: MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGENFALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEIDGRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLRLEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABC3G_MACMU
Sequence: MVEPMDPRTFVSNFNNRPILSGLNTVWLCCEVKTKDPSGPPLDAKIFQGKVYSKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANSVATFLAKDPKVTLTIFVARLYYFWKPDYQQALRILCQKRGGPHATMKIMNYNEFQDCWNKFVDGRGKPFKPRNNLPKHYTLLQATLGELLRHLMDPGTFTSNFNNKPWVSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAPNIHGFPKGRHAELCFLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLCIFAARIYDDQGRYQEGLRALHRDGAKIAMMNYSEFEYCWDTFVDRQGRPFQPWDGLDEHSQALSGRLRAI
What is the function of this protein?
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms.  Exhibits antiviral activity against vif-deficient: HIV-1 and simian immunodeficiency viruses (SIVs).  After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA.  The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.  Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.  May inhibit the mobility of LTR retrotransposons.
What are the official names of this protein?
DNA dC->dU-editing enzyme APOBEC-3G, Deoxycytidine deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic, small amount are found in the nucleus.
Protein: CM3I_CONRE
Sequence: CCAIRLCNVYLCGSCCP
What are the official names of this protein?
Conotoxin reg3i.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NUON_RHOCS
Sequence: MVAIPDFLPALPEMFLACAAMALLMLGVFRGADSTRLVSWLAVGAALVAGVLVLAASGDRAVTFAGMFIADDFAVFAKVLILTATALTVVLSVNYLEREQMDRFEYPVLMLLATVGMMLMVSANDLISLYVGLELQSLSLYVIAAFRRDYAKSSEAGLKYFLLGSLSSCILLYGASLIYGFSGTTNFERLAVMFSSDVPAATGVVVGLVFVAAGLAFKISAVPFHMWTPDVYEGAPTSVTAFFAVAPKVAALALFVRVLVDPFGELLAQWQQVVWFSAVASMLLGSLAAIQQRNIKRMMAYSSIGHIGYALVGLAAGTEEGVRGVLIYLAIYLAMNVGTFAVILSMRVNGRMVENIDDLSGLSRSHPMMALAMAFFMFSLGGVPPMAGFFGKLYVFMAAIEAQLYVLAVIGVLTSVISLFYYLRIVKVMWFDDLMETIERPARASALVIGGTALFVFPVFYVFSEGILNGAAAAASTLFLR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MCP_EBVG
Sequence: MASNEGVENRPFPYLTVDADLLSNLRQSAAEGLFHSFDLLVGKDAREAGIKFEVLLGVYTNAIQYVRFLETALAVSCVNTEFKDLSRMTDGKIQFRISVPTIAHGDGRRPSKQRTFIVVKNCHKHHISTEMELSMLDLEILHSIPETPVEYAEYVGAVKTVASALQFGVDALERGLINTVLSVKLRHAPPMFILQTLADPTFTERGFSKTVKSDLIAMFKRHLLEHSFFLDRAENMGSGFSQYVRSRLSEMVAAVSGESVLKGVSTYTTAKGGEPVGGVFIVTDNVLRQLLTFLGEEADNQIMGPSSYASFVVRGENLVTAVSYGRVMRTFEHFMARIVDSPEKAGSTKSDLPAVAAGVEDQPRVPISAAVIKLGNHAVAVESLQKMYNDTQSPYPLNRRMQYSYYFPVGLFMPNPKYTTSAAIKMLDNPTQQLPVEAWIVNKNNLLLAFNLQNALKVLCHPRLHTPAHTLNSLNAAPAPRDRRETYSLQHRRPNHMNVLVIVDEFYDNKYAAPVTDIALKCGLPTEDFLHPSNYDLLRLELHPLYDIYIGRDAGERARHRAVHRLMVGNLPTPLAPAAFQEARGQQFETATSLAHVVDQAVIETVQDTAYDTAYPAFFYVVEAMIHGFEEKFVMNVPLVSLCINTYWERAGRLAFVNSFSMIKFICRHLGNNAISKEAYSMYRKIYGELIALEQALMRLAGSDVVGDESVGQYVCALLDPNLLPPVAYTDIFTHLLTVSDRAPQIIIGNEVYADTLAAPQFIERVGNMDEMAAQFVALYGYRVNGDHDHDFRLHLGPYVDEGHADVLEKIFYYVFLPTCTNAHMCGLGVDFQHVAQTLAYNGPAFSHHFTRDEDILDNLENGTLRDLLEISDLRPTVGMIRDLSASFMTCPTFTRTVRVSVDNDVTQQLAPNPADKRTEQTVLVNGLVAFAFSERTRAVTQCLFHAIPFHMFYGDPRVAATMHQDVATFVMRNPQQRAVEAFNRPEQLFAEYREWHRSPMGKYAAECLPSLVSISGMTAMHIKMSPMAYIAQAKLKIHPGVAMTVVRTDEILSENILFSSRASTSMFIGTPNVSRREARVDAVTFEVHHEMASIDTGLSYSSTMTPARVAAITTDMGIHTQDFFSVFPAEAFGNQQVNDYIKAKVGAQRNGTLLRDPRTYLAGMTNVNGAPGLCHGQQATCEIIVTPVTADVAYFQKSNSPRGRAACVVSCENYNQEVAEGLIYDHSRPDAAYEYRSTVNPWASQLGSLGDIMYNSSYRQTAVPGLYSPCRAFFNKEELLRNNRGLYNMVNEYSQRLGGHPATSNTEVQFVVIAGTDVFLEQPCSFLQEAFPALSASSRALIDEFMSVKQTHAPIHYGHYIIEEVAPVRRILKFGNKVVF
What is the function of this protein?
Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers).  Hexons form the edges and faces of the capsid and are each composed of six MCP molecules.  In contrast, one penton is found at each of the 12 vertices.  Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex.  The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.
What are the official names of this protein?
Major capsid protein, MCP.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae major capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: AP3M1_RAT
Sequence: MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPTVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHNISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLAWDVGKITPQKLPSLKGLVNLQSGAPKPEENPNLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYITKAGKFQVRT
What is the function of this protein?
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated.  The complex is associated with the Golgi region as well as more peripheral structures.  It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.  In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
What are the official names of this protein?
AP-3 complex subunit mu-1, AP-3 adaptor complex mu3A subunit, Adaptor-related protein complex 3 subunit mu-1, Clathrin assembly protein assembly protein complex 3 mu-1 medium chain, Clathrin coat assembly protein AP47 homolog 1, Clathrin coat-associated protein AP47 homolog 1, Golgi adaptor AP-1 47 kDa protein homolog 1, HA1 47 kDa subunit homolog 1, Mu-adaptin 3A, Mu3A-adaptin, P47A.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: PUR9_HUMAN
Sequence: MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
What is the function of this protein?
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554).  Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:9378707, PubMed:11948179, PubMed:10985775).  Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775).  Also catalyzes the cyclization of FAICAR to IMP (PubMed:11948179, PubMed:14756554).  Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775).  Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).
What are the official names of this protein?
Bifunctional purine biosynthesis protein ATIC, AICAR transformylase/inosine monophosphate cyclohydrolase, ATIC.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: SPVR_SALDU
Sequence: MDFLINKKLKIFITLMETGSFSIATSVLYITRTPLSRVISGLERELKQRLFIRKNGTLIPTEFAQTIYRKVKSHYIFLHALEQEIGPTGKTKQLEIIFDEIYPESLKNLIISALTISGQKTNIMGRAVNSQIIEELCQTNNCIVISARNYFHRESLVCRTSVEGGVMLFIPKKFFLCGKPDINRLAGTPVLFHEGAKNFNLDTIYHFFEQTLGITNPAFSFDNVDLFSSLYRLQQGLAMLLIPVRVCRALGLSTDHALHIKGVALCTSLYYPTKKRETPDYRKAIKLIQQELKQSTF
What is the function of this protein?
Positive regulator for the plasmid-encoded virulence factors SpvA, SpvB, and SpvC.
What are the official names of this protein?
Virulence genes transcriptional activator SpvR.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_CHLAA
Sequence: MAELYYDNQADLNRLKNKPIAIIGFGSQGHAHARNLADSGLDVRVGLYPGSKSWAKVEAAGLKVMTVAEAAREAQIVMILTPDIGQADLYREHIAPAMEPGKTLMFAHGFNIRFGQIIPPQGIDVSMVAPKAPGHRVREVFVQGGGVPALIAVEQDATGGAFEDALAYAKGLGCTRAGVLRTTFAEETETDLFGEQVVLCGGVSALVKAAFETLVEAGYQPEVAYFECMHELKLIVDLFYQGGLNYMRYSVSDTAEWGDYTAGPKIITDQTRAAMRQILADIQSGAFAEDWIDENHNGRPRFNAYRQADINHPIEQIGRELRRMMPFVNPREVKPGEGGA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: FTSZL_MAGGM
Sequence: MFGVEPISFCEDMTMIRPRIIVIGVGGAGGNAVNNMILSKIEGVEFIAANTDAQALGLSLADRRIPLGGYVTKGLGAGSRPELGRSAAQESIDDILTAIDDANMVFITAGMGGGTGSGAAPVIAQAARERGILTIGVVTKPFHFEGGHRMGTAEAAIEELQHVVDTLIIIPNQNLFRIASERTTFIDAFKMADNVLNSGVRSVTDLVVKPGLINLDFADIRIVMSEMGKAIMGTGEAEGEPRAVKAAEAAISNPLLGDTSIAGAKGVLINITGGMDMTLFEVDEAANRIRTEVAPDANIIFGSTFDEKLDGKMRVSVVATGIA
What is the function of this protein?
Required for synthesis of single-domain magnetite particles and magnetosomes, especially in the absence of nitrate.  Forms filaments, which form bundles in the presence of GTP.  Has both GTPase and ATPase activity; GTPase is 2. 5 time more efficient.  Has no activity on CTP or TTP (PubMed:20023033).  May be involved in redox control for magnetite crystallization (Probable).  Mild overexpression causes cell elongation (PubMed:24272781).  May recruit other proteins (MamX, MamY and MamZ and possibly Mms6) to a complex required for biomineralization (Probable).
What are the official names of this protein?
FtsZ-like protein.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Upon mild overexpression assembles into foci at midcell and at cell poles, foci colocalize with FtsZ but not with MamK filaments. Subcellular location is independent of other magnetosome locus encoded proteins, but may depend on FtsZ (PubMed:24272781). A similar construct shows a dispersed location at 6 hours post-induction and a dot-like distribution at 18 hours post- induction (PubMed:30367002).
Protein: YCX9_EUGLO
Sequence: MMNINSSFNNDGTQDPKKDLILSNSNENEYDYIIKLIYENLYNICFSINFVLKKIYLDKFVYKYLPYIEIFLKMNKEKCCCRLKKFFEKDKIKLYKIYHKFKNFLTLNFSNSFTYMIKINIY
What are the official names of this protein?
Uncharacterized 15.0 kDa protein in rpl12-rps7 intergenic region, ORF122.
What are the subcellular locations of this protein?
Plastid.
Protein: RL35_METPB
Sequence: MPKLKTKSGAKKRFKVTGTGKVVYAQAGKRHGMIKRTNKQIRNLRGTTTLFEGDAANVKKYFLPNQR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ACP_AZOPC
Sequence: MSQISERVIDLISEKLNVEKSEVTLEADFANNLGADSLDTVELIMDLEKEFNMNPIPNDESIAIKTVGDAIAYIESHANEAATKS
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VRAR_STAAW
Sequence: MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
What is the function of this protein?
Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis.  Upon cellular stress, the histidine kinase VraS transfers the phosphoryl group onto VraR.  Upon phosphorylation, VraR dimerizes at the N-terminal domain.  In turn, phosphorylation-induced dimerization expands and enhances the VraR binding to its own promoter leading to increased expression and subsequent modulation of as many as 40 genes, which ultimately constitute the S. aureus response to cell wall damage (By similarity).  In addition, inhibits the host autophagic flux and delays the early stage of autophagosome formation, thereby promoting bacterial survival.  Facilitates the ability of S. aureus to resist host polymorphonuclear leukocytes-mediated phagocytosis and killing thus contributing to immune evasion (By similarity).
What are the official names of this protein?
Response regulator protein VraR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIN3_ARATH
Sequence: MGITYLHISVATTALSFVGLQVWTELSLDRLRADGIITKNISLGNSENTLELLLSSHTTIALLASFVLNIYILLVLSLKTLFFGDLYAIETRKLVERLANYIIYKGTFLPFVVPRTVFQGVLWTIWLTVLCTLKMFQALARDRLDRLNASPSSTPWTYFRVYSALFMVLSTDLCWIKLSLMIYNTVGSSVYLLLLFEPCGIAFETLQALLIHGFQLLDMWINHLAVKNSDCQRSKFYDSMTAGSLLEWKGLLNRNLGFFLDMATLVMALGHYLHIWWLHGMAFHLVDAVLFLNIRALLSSILKRIKGYIKLRVALGALHAALLDATSEELRDYDDECAICREPMAKAKRLHCNHLFHLGCLRSWLDQGLNEVYSCPTCRKPLFVGRTESEANPSRGEVSSDEHLARQFERQNNSVHALTTGMFPTETPNFTESDPWRNSEVDPSWLQTWSDQGVDVVGSSAGSRSVGLGQVQLMMRHLASVGEGSAQTTLDDASWGLWPMNPSQASTSSTYVPPGAGGRTGGLHLRTVSRAANNMASILAMAETVREVLPHVPDEIIFQDLQRTNSVSVTVNNLLQM
What is the function of this protein?
E3 ubiquitin protein ligase that acts as positive regulator of RPM1- and RPS2-dependent hypersensitive response (HR), in association with RIN2.  Probably not required for RPM1 degradation during HR.
What are the official names of this protein?
E3 ubiquitin protein ligase RIN3, RING-type E3 ubiquitin transferase RIN3, RPM1-interacting protein 3.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: PARE_CAUVC
Sequence: MSSSDKIPSLFGDDDALAPVPAAPFKASVEPRVEPTPRPIPPPPPSKTASAPGEYSAADIEVLEGLEPVRKRPGMYIGGTDERALHHLFAEVLDNSMDEAVAGFAKTIEVKLDADGFLSVKDDGRGMPVDPHPKYPGKSALEVIMTVLHAGGKFTGKAYETSGGLHGVGASVVNALSERVEVTVWRDGFEHLQVFSRGKPLGPIQQVAPSKKKGTMVRFKPDDEIFGEGTNFKPARLYRMARSKAYLFRGVQIKWSCDPSRIHDQTPPEATFHFPNGLADFLAERTKGLTTITPESFAGRIERQGEAGAVEWAVTWTPQGFGEHDGFMQSYCNTVPTPEGGTHESGFRAALTRGLKAYAELKGEKRGTIITADDVVAQAGALISVFIKNPEFQGQTKEKLSTSEAQRFVEASLRDPFDLWLSSSPKNAQALLEFVIERAEERLKRRKDKEVSRASATRKLRLPGKLADCAGSAVDGAELFIVEGDSAGGSAKQARDRKYQAILPLRGKILNVASASGEKFTANKELSDLMLALGAQAGAKYREEDLRYERIIIMTDADVDGAHIASLLITFFYRTMPELIRGGHLFLALPPLYRLAHGGKSEYARDDAHKEELLATVFKGKKPEIGRFKGLGEMMASQLKETTMDPKKRTLARVTLPRHEESVEDLVETLMGRKPELRFRFIQENAEFASADLDL
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA.  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit B, Topoisomerase IV subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Protein: MAMB1_DENAN
Sequence: RPSFCNLPVKPGPCNGFFSAFYYSQKTNKCHSFTYGGCKGNANRFSTIEKCRRTCVG
What is the function of this protein?
Selectively interacts with vasopressin V2 receptor (V2R/AVPR2) and fully inhibits three major signaling pathways of this receptor that are GalphaS protein, the interaction with beta-arrestin and activation of MAP kinase (PubMed:28630289, PubMed:35122240).  Inhibits vasopressin binding human V2R in the nanomolar range (Ki=5. 02 nM), and also potently inhibits vasopressin-induced cAMP production (IC(50)=94 nM) (PubMed:35122240).  In vivo, this protein shows an aquaretic effect (PubMed:28630289, PubMed:35122240).  Urine output increases and urine osmolality decreases dramatically under treatment with this protein, without differences observed between healthy mice and the pcy mice model of the autosomal-dominant polycystic kidney disease (ADPKD) (PubMed:28630289).  This protein does not modify electrolyte, protein and urea excretions in the urine samples, but produces a 3-fold decrease of creatinine levels (PubMed:28630289).  Intraperitoneal injection of this protein into the pcy mice significantly reduces the number of renal cysts and the total area of cysts (PubMed:28630289).  This protein also shows high efficacy in preventing hyponatremia in rat models (induced by DAVP) (PubMed:33052234).  Is highly visible in mice liver and kidney after intravenous injection (PubMed:33052234).  Is rapidly eliminated in the liver, whereas it exhibits slow elimination in the kidney due to the high expression of V2R which acts as a reservoir (PubMed:33052234).  In addition, its elimination from blood is rapid (PubMed:33052234).  Fluorescent MQ1 probes could also be used for imaging V2R-overexpressing cancer cells; note that these probes label the three renal cancer cell lines CAKI-2, ACHN and A498 that highly express V2R (PubMed:33052234).  In vivo, does not show any toxicity on animals, even at highest doses tested, such as prostration, spidy coat, appetite or weight loss (PubMed:33052234).
What are the official names of this protein?
Mambaquaretin-1, MQ-1, MQ1, Upsilon-Da2a.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOD_RHOCA
Sequence: MDGDIRHNSYDDGSEDVLTGEQSIRNFNINFGPQHPAAHGVLRMVLELDGEIVERADPHIGLLHRGTEKLMESRTYLQNTPYFDRLDYVAPMNQEHAWCLAIEKLTGTAVPRRASIIRVLFSEIGRILNHLLNVTTQAMDVGALTPPLWGFEEREKLMIFYERACGARLHANYFRPGGVHQDLPPDLIDDIEIWAKAFPQVLDDIEGLLTENRIFKQRNADICIITEAEIEKWGYSGVMVRGSGLAWDLRRAQPYECYDEFDFKVAVGKNGDCYDRYLVRMAEMRESTKIILQACAKLRAPDGQGDILARGKLTPPKRAEMKTSMEALIHHFKLYTEGFKVPAGEVYAAVEAPKGEFGVYLVADGTNKPYRAKIRAPGYAHLQSIDAVAKGHQLADVSAIIGTMDVVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GLO2_PROM9
Sequence: MEFNKAQNIIGLRVLNDNVIWLWEKDKSVVVIDPAIHEPVIRYIDENNLYIKAILQTHHHSDHIGGTKYLIERWPNVQVIASSKDKKRIPFQNISVEDGETLNILGEEIKIIEVLGHTNSHIAFFVNGESPVLFIGDTLFSGGCGRIFEGTYQQMYSSLERIKSLPKNTLIYCAHEYTKANLLWALNLKPKDQDIKNKLLQVEKKLSINELTIPFLLDEEMKINLFLRAKNLKEFTFLRENKDLWV
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: Y564_BUCAP
Sequence: MSSNVTLVDKLNPIRHKELKVKIDEICHKSLKNLKNTSKILIEEKKHPISSTKVSINYIENENENKNNLINLENFYKKYLLKFNDFIMKKKLFLNPLLSPLLKVLPTIHSIY
What are the official names of this protein?
Uncharacterized protein BUsg_564, yba4.
What is the protein family that this protein belongs to?
To Buchnera BU585.
Protein: RSMH_BURMA
Sequence: MGNEFQHRTVLLDEAVDALVTRPDGVYVDGTFGRGGHSRAVLARLGDAGRLIAFDKDPRAIETAESIEDARFEIVHDSFAAMKGALDARGVGRVSGVLLDLGVSSPQVDDPARGFSFRANGPLDMRMDPTRGESAAEWLARASVQELTEVIRDYGEERFAFQIAKAIVARRAESDRLGPLDSTGELAQIVGHVVKTREKGKDPATRTFQAIRIHVNQELADLQVVLEAALSLLEQGGRLVVISFHSLEDRIVKRFLQAHASAPAVDRRLPIRAADLPRPPLKLLGRMFPNDAEVAANPRARSAVMRIAERVAP
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.