PharMolix/UniProtQA huggingface dataset:
Protein: VP7_BTV2A
Sequence: MDTIAARALTVMRACATLQEARIVLEANVMEILGIAINRYNGLTLRGVTMRPTSLAQRNEMFFMCLDMMLSAAGINVGPISPDYTQHMATIGVLATPEIPFTTEAANEIARVTGETSTWGPARQPYGFFLETEETFQPGRWFMRAAQAVAAVVCGPDMIQVSLNAGARGDVQQIFQGRNDPMMIYLVWRRIENFAMAQGNSQQTQAGVTVSVGGVDMRAGRIIAWDGQAALHVHNPTQQNAMVQIQVVFYISMDKTLNQYPALTAEIFNVYSFRDHTWHGLRTAILNRTTLPNMLPPIFPPNDRDSILTLLLLSTLADVYTVLRPEFAIHGVNPMPGPLTRAIARAAYV
What is the function of this protein?
The VP7 protein is one of the five proteins (with VP1, VP3, VP4, and VP6) which form the inner capsid of the virus.
What are the official names of this protein?
Core protein VP7.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP7 family.
What are the subcellular locations of this protein?
Virion.
Protein: HIS6_CERS4
Sequence: MLKTRIIPCLDVADGRVVKGVNFVDLRDAGDPVEAARAYDAAGADELCFLDIHATHENRGTMYDLVTRTAEQCFMPLTVGGGVRTHQDVRALLLAGADKVSFNSAAVADPGVVAEAADRFGSQCIVVAIDAKTVAPGRWEIFTHGGRRATGIDAVAFACEMASRGAGEILLTSMDRDGTRAGFNLPLTRAISDAVPIPVIASGGVGTLDHLVEGVTEGGASAVLAASIFHFGEFTIGEAKAHMAAAGIPVRLA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M3K15_MOUSE
Sequence: MEGGGGSGGGGGPVPAEAPEEAGEPPQGRLPPGPEGAAGLAEPESTGDAAGGEAEGGRGPRRALRAVYVRSESSQGAAAGGGPEAGALKCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAIVDMSDISRQPSLFYHLGVRESFDMANNVILYYDTDADTALSLKDMVTQKNTASSGNYYFIPYTVTPCADYFCCESDAQRRASEYMQPNWDTILGPLCMPLVDRFTSLLKDIRVTSCAYYKETLLNDIRKAREKYQGDELAKELTRIKFRMDNIEVLTSDIIINLLLSYRDIQDYDAMVKLVETLKMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQVMLQVLQSCDHPAPDMFCLCGRIYKDIFLDSGCEEDASRDSAIEWYRKGFELQSSLYSGINLAVLLIVSGQQFETSMELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFTVSMLASDIGKAVQAAERLFKLKPPVWYLRSLVQNLLLIQRFKKPITEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQIHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEDQCNRFCSLVKEMLNNGVGSTVELEGEADGDTLEYEYDHDANGERVVLGKGSYGIVYAGRDLSNQVRIAIKEIPERDIRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQEGFLRQVNKGKKNRIAFKPSEGVRSGTGTLALPSSGELVGSSSSEHGSISPDSDAQPDAFFEKVQVPKHQLSHLLSVPDESPALDDRSTALPPEERDPGLFLLRKDSERRAILYRILWEEQNQVASNLQECVVQSSEELLLSVSHIKQIIGILRDFIRSPEHRVMAATISKLKVDLDFDSSSINQIHLILFGFQDAVNRILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELQAHFEPASETEGVDKDTEVEGDYPLVDLLSQEVHVTPRGTRPGSVAIQEGQPHQQDPSLQLSKLRQETNRLWEHLVQKEREYQNLLRLILDQKTQELYHLQLQYKSNGGTENPPPPDGLGTDRELIDWLQLQGVDANTIEKIVEEDYTLSDILNDITKEDLRCLRLRGGVLCRLWHAVSQHRRQMQESSQ
What is the function of this protein?
May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 15, MAPK/ERK kinase kinase 15, MEK kinase 15, MEKK 15.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Protein: TPIS_PROMA
Sequence: MRKTVIAGNWKMHMTCSSAKEYIDKFIPFSKEFPSDRHVVIAPPFTAISTLASLLQGTNIQLSSQNVHWEDTGAFTAEISPSMLLEHDVRYAIVGHSEPRKYFSESDEQINLRARSAQSNGLIPIVCVGESIEQRERGEAERVIRRQVEQGLEQTDLTKLVIAYEPIWAIGTGKTCESNEANRICGLIREWAGFSDLIIQYGGSVKPANIDEIMSMSDIDGVLVGGASLDPENFARIANYQSI
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_BUCAP
Sequence: MSMQDPVADMLTRIRNGQSANKYSVKMPCSKLKYSIIELLKKEGYIKNFNIQGNNKLKIEVILKYFKGKSVIETIQRVSRPSLRIYKKKNNLPTVMAGLGIAIISTSQGIMTDRKARRLGLGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SHE9_ASPOR
Sequence: MDNLQSNIFVAGQRLNDLTGYSSIEALKKDIHTQEERLRAARLRVREAKDAYAAAINNRSTSQREVNELLQRKHAWSASDLERFTHLYRNDHTNEVAENEAQEALSAAERESEEAAAQLNKSILSRYHEEQVWSDKIRRMSTWGTWGLMGVNVLLFLIFQIAVEPWRRKRLVKGFEEKVIEAIEKEKAMHHVEILAPVNAAQEIPAAPSADSSAPVVAAVPSPAAEETASNAISTEVLDVPDSATPAPDTTTTPNSQNSLNDLLESAKLQLSRFPPPTSVESWRQYISDLFSDRNLVITQRDLSSLALQSAAAGAAIMGLVIALIRPR
What is the function of this protein?
Required for the maintenance of the structure of the mitochondrial inner membrane.  Involved in mitochondrial morphology.  Causes growth arrest when highly overexpressed (By similarity).
What are the official names of this protein?
Sensitive to high expression protein 9 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the SHE9 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PCKA_SHESW
Sequence: MADGLHRVHYNPSTAQLVEFALLRGEGELTANGALVAKTGARSGRSPGDRFIVKEPSSEADIEWGPVNQAFEPGAFEGLWARVEAYLADKELFVSDLEVGADTEHYQPVRVTTQYAWHQLFARNLFIIPEEFNRKDKPVWQIINAPDFVCDPARDGTNSDAAVILNFAERKVLLAGLKYAGEMKKSMFSVQNFLLPAQGVLPMHCSANVGKDGDTTLFFGLSGTGKTTLSADPKRFLIGDDEHGWAPGGVFNIEGGCYAKCIDLSQKNEPVIWDAIRFGTVLENVVMDEHRVPNYKDSSLTENTRAAYPLEHIAQRKEDNCGAEPHAVVFLTCDVSGVLPPVSILTKEQAAYHFLSGYTAKVGSTEIGSTSAIQSTFSTCFGAPFFPRPAGVYAELLMKRIESFGSQVYLVNTGWTGGPHGLGKRFDIPTTRAIVDAIVSGELKDVETIHLDTLNLAVPVAVTGVDSNLLNPINTWGDKALYAEYAQKLAEAFTKNFAKYQVSDAIRHAGPKA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNFB_ECO7I
Sequence: MKITLSKRIGLLAFLLPCALALSTTVHAETNKLVIESGDSAQSRQHAAMEKEQWNDTRNLRQKVNKRTEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVITP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: Y170_ATV
Sequence: MVDYKKVYLLNISIRRFTKRRSMTKYEEDKKIRIIEEYFDGNEDIPPRLSFLISGISVSTRLFRLLYPHKMSQVPSVLEEVKKYLNGRNGIEVVLDYFPLYLPKPILLGLLNEALLKKKARYNQIRNDPFKSEYDKQRALAMLEESLKDIQIFIEYLKKEDGLQSIQKLA
What are the official names of this protein?
Uncharacterized protein ORF170.
Protein: MCE_MYXVU
Sequence: MEPVSMDKPFMYFDEIDDELEYEPESVNETPKKLPHQGQLKLLLGELFFLSKLQRHGILDGSTIVYIGSAPGTHIKYLRDHFMSMGLVIKWMLIDGRTHDPILEGLRDVILITKFVDEAYIRQLKKQLYPSRVILISDVRSKRGQKEPTTQDLLSNYSLQNIMVSVLKPAASSLKWRCPFPDQWIKDFYVPHGNEMLQPFAPSYSAEMRLLSIYSGTPIRLKCITQQDSSKYEKKMYYLNKIIRNRIIINFDYSNQEYDFFHMYHMLKTVYSNKSFTSNKSKVLHFHQSIFRFLKIPITNTEKIHHEPTQRKVPSKNTMLKSRNTKKSVRGNKQGRRT
What is the function of this protein?
Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities.  Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation.  At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap.  At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail.  In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.
What are the official names of this protein?
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, Poly(A) polymerase regulatory subunit, Poly(A) polymerase small subunit, PAP-S, VP39.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Poxvirus/kinetoplastid 2'-O-MTase family.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: RSMG_STRT1
Sequence: MTPEDFYMALKELGFDLSQKQKDQFQRYFELLVEWNEKINLTAITDKDEVFLKHFYDSLAPVLQGHIKNQSIQLLDIGAGAGFPSLPIKILCPNLDVTIIDSLNKRITFLNFLSDELGLSGVHFYHGRAEDFGQDKAFRAQFDIVTARAVARMQVLSELTIPFLKVGGQLIALKAAAADQELVDARNALNVLFAKPILNENYKLPNGDGRNITIIDKKKETPNKYPRRAGIPNKKPL
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALS2_CANAX
Sequence: MLLQFLLLSLCVSVATAKVITGVFNSFDSLTWTRAGNYAYKGPNRPTWNAVLGWSLDGTSANPGDTFTLNMPCVFKFITDQTSVDLTAEGVKYATCQFYSGEEFTTFSSLKCTVSNTLTSSIKALGTVTLPISFNVGGTGSSVDLESSQCFKAGTNTVTFNDGDKKISIDVDFEKTNEDASGYFIASRLIPSINKVSITYVAPQCANGYTSGAMGFIVLTGDTTIDCSNVHVGITKGLNDWNFPVSSDSLSYNKTCSSTGISITYENVPAGYRPFFDVYTSVSGQNRQLRYTNDYACVGSSLQSKPFNLRLRGYNNSEANSNGFVIVATTRTVTDSTTAVTTLPFNPSVDKTKTIEILQPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDVPYHTTTTVTSEWTGTITTTTTRTNPTDSIDTVVVQVPSPNPTVTTTEYWSQSYATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTLTITAPPGGTNSVIIRVHSSTNDESSESTFSTLSVPSFSGSISVVSIISRPHYVNSTVTHLPSSSSKPVDIPSSDAVTSTNDNSLTSLTGSENGKTSVAISTTFCDDENGCQTSIPQGSVVRTTATTTATTTTIIGDNNGSGKSKSGELSPTGSVTTNTATPNVPSTKVPSNPGAPGTGVPPPLAPSTETQTTNNVPGSPNIPATGTTDIIRESTTVSHTVTGNGNTGVPMNPNPALTTGTSLTGATNSATNPSHETGVNTGSGGSTNIVTPPSSATATVVIPGTDNGATTKGQDTAGGNSNGSTATTNTQGGNNEPGNQPGTNTTGEPVGTTGTQSVELISQQTTLSQQTTSSLISTPLASTFDGSGSIVQHSGWLYVLLTAISIFF
What is the function of this protein?
Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation.  Plays an important role in the pathogenesis of C. albicans infections.
What are the official names of this protein?
Agglutinin-like protein 2, Adhesin 2.
What is the protein family that this protein belongs to?
Belongs to the ALS family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer.
Protein: RL13_PSECP
Sequence: MRTYTPKPGDINRQWHVIDATDVVLGRLASQTAILLRGKHKATFASHMDMGDFVIIINAEKVALTGAKLEQKRAYRHSGYPGGLTSVNYAELLESNPVRAVEKAIKGMLPKNSLAAQQLGKLKVYRGAEHPHAAQQPKTFEITQVAQ
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RS11_THEAB
Sequence: MAKKTRRVVKRKKKLTVDRGVVHIKSTYNNTIITLTDPDGKVITWGSGGTAGFQGTRKGTPYAAQLAADQVAKEAVKLGMKKVDILVKGPGSGREAAIRTFQAAGLEIGVIKDVTPIPFNGCRPKKKRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: LEXA_SHIF8
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVDLRQQSFTIEGLAVGVIRNGDWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: GLUQ_YERPS
Sequence: MVQQAVIQRSANQQLSNQRSANQRATNQPTEYVGRFAPSPSGDLHFGSLIAALGSYLQARAQGGKWLVRIEDIDPPREVPGAASRILAALEHYGLHWDGPVIYQSQRHEAYRATLNWLEQQGLSYYCTCTRSRIHQLGGFYDGYCRDRHLPASGAAIRLRQTQPVYAFYDKLLGELHAHPALAQEDFIIRRRDGLFAYNLAVVVDDAFQGVTEIVRGADLIEPTVRQIALYQQLQHPVPSYIHLPLALNNQGNKLSKQNHAPPLPNGDPRPILIDALKFLRQPLPEYWQDLDLYLLLRYAVEHWTLVSIPLQGAITPQKTQRHSQSKHGEL
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: MCM3_ARATH
Sequence: MDVPEETRLRHKRDFIQFLDSMYMEEIKALVHQKRHRLIINISDIHHHFREVASRILKNPNEYMQSFCDAATEATRAIDPKYLKEGELVLVGFEGYFVSRVVTPRELLSDFIGSMVCVEGIVTKCSLVRPKVVKSVHFCPSTGEFTNRDYRDITSHAGLPTGSVYPTRDDKGNLLVTEYGLCKYKDHQTLSIQEVPENAAPGQLPRSVDVIAEDDLVDSCKPGDRVSVFGIYKALPGKSKGSVNGVFRTILIANNIALLNKEANAPIYTKQDLDNIKNIARRDDAFDLLARSLAPSIYGHAWIKKAVVLLMLGGVEKNLKNGTHLRGDINMMMVGDPSVAKSQLLRAIMNIAPLAISTTGRGSSGVGLTAAVTSDQETGERRLEAGAMVLADKGIVCIDEFDKMNDQDRVAIHEVMEQQTVTIAKAGIHASLNARCSVVAAANPIYGTYDRSLTPTKNIGLPDSLLSRFDLLFIVLDQMDAGIDSMISEHVLRMHRYKNDRGEAGPDGSLPYAREDNAESEMFVKYNQTLHGKKKRGQTHDKTLTIKFLKKYIHYAKHRITPKLTDEASERIAEAYADLRNAGSDTKTGGTLPITARTLETIIRLATAHAKMKLSSEVTKADAEAALKLMNFAIYHQELTEMDDREQEERQREQAEQERTPSGRRGNQRRNNEDGAENDTANVDSETADPMEVDEPSVEQFSGTVSAARIETFERVFGQHMRTHRLDDISIADIETVVNNNGVGASRYSADEIMALLEKLQDDNKVMISDGKVHII
What is the function of this protein?
Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.
What are the official names of this protein?
DNA replication licensing factor MCM3, Minichromosome maintenance protein 3, AtMCM3.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CX6A2_MOUSE
Sequence: MALPLKVLSRSMASAAKGDHGGAGANTWRLLTFVLALPGVALCSLNCWMHAGHHERPEFIPYHHLRIRTKPFAWGDGNHTLFHNPHVNPLPTGYEHP
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.  Plays a role in the assembly and stabilization of complex IV (PubMed:31155743).
What are the official names of this protein?
Cytochrome c oxidase subunit 6A2, mitochondrial, Cytochrome c oxidase polypeptide VIa-heart, COXVIAH.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 6A family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: GLMM_DESAP
Sequence: MGALFGTDGVRGLANEELSPELAFKLGRAGAFVLQEETGARALVIGRDTRLSGDMLEAALVAGICSVGVDVIRVGVLPTPAIAYLSRAPEAGGGVVISASHNPYEDNGIKFFGANGYKLPDRLEDRIEHLVLTAGGALPTPSGIGVGRVREMPDAMERYVRFACGTGPSDLAGLKIVVDCANGAAYQVAPQVLGRLGASVVPLFDTPDGTNINAGCGSTHPHVLQQAVPAEGADLGLAFDGDADRLIAVDEHGRLVDGDHLLVICGRHMRRHGRLAGNTMVVTVMSNLGLHLALREAGIRVLQTKVGDRYVLEEMLRSGCCLGGEQSGHIIFTEYNTTGDGIITALQLLKVMRETGRPLSQLAAQMERLPQLLENVRVRDRNAVMSSPALWEAIARYEHGLNGEGRILVRPSGTEPLVRVMAEARNETLLTKVVEELVRVVTEIDRQQAG
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: LEUC_SERP5
Sequence: MSKTLYQKLYDAHVVYSAPEETPLLYIDRHLVHEVTSPQAFDGLRAMGRKVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCEEFGVLLYDLNHPYQGIVHVIGPEQGMTLPGMTIVCGDSHTATHGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGDAAEGITAKDIVLAVIGKTGSAGGTGHVVEFCGKAIQALSMEGRMTLCNMAIEMGAKAGLVAPDDTTFDYLKGRQFAPTGSNWEQAVAYWRTLKSDDDAKFDTVVTLRAEDIAPQVTWGTNPGQVIAVNQTIPAPESFSDPGERASAEKALAYMDLKPGIKLTEVPIDKVFIGSCTNSRIEDLRAAAAIAKGRKVASGVQAIVVPGSGPVKAQAEAEGLDKIFIDAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAIAGHFADIRDIH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: BTUC_PHOLL
Sequence: MQSTHSIAELVTRQKRHDYRFLAILTCLFLLVFFLSLCAGENWIWPNKWFSETGQLFVWQLRFPRVLAVVAVGASLTVAGAVMQALFENPLAEPGLLGVSNGAGVVVVFLVLMFHGIAPFWLLSIGAVLGALTVTMILLTFSRNRYLNNARLLLVGVAFGVASGALMTWMVYFSTSLDLRQLMYWMMGSFSGIDWRHQWLVVALFPLIIWLSRQGKVLNFLSLGETQAQQLGISLYYWRNLFVFAVGLLVGLSVALAGTISFIGLVIPHILRLCGLTDYKTLLPACVLSGGYGLLLADLLSRLSLNNAEVPIGVVTATLGAPVFIWLLLRVRDWS
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Involved in the translocation of the substrate across the membrane.
What are the official names of this protein?
Vitamin B12 import system permease protein BtuC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYV_METMP
Sequence: MEIKEEYSIELEKKVQEKWEDEKTFKFLDDEKRPPYIIDTPPPYPTGRMHLGHGLNWTYMDIIARFKRMNGYDVLFPQGWDCHGLPTEVKVEELNNITKSDIDRHEFRRLCVELTDENVEKMRGQVRSLGISIDWDREYITMNPDYVRKSQTAFLKMYEKGLIYRGKHPVNWCPRCETAIAFAEVEYQGRTSKLNYIKFPYAENSGKYLEIATSRPELMAACVGIVVHPEDERYSDVVGKTVKVPLFDQEVNVYPDSDVEKEFGTGVVMVCTFGDKTDVTWVNRHKLEVKKAINEKGQLTEICGKYAGKKSDDARKEIISDLISENYMIKQEPLEQNVGSCWRCKTPIEIIVGDQWFVNVTKLLTEVENAANEISWVPEHMKARLMKWIEDMGWDWCISRQRLFATPIPVWYCKDCGEIIVAKPEDLPIDPTKESPYTCKCGNSNLVAETDVLDTWMDSSITPLVIAGWLEDEEFFKKHYPVQLRPQGHDIIRTWAFYTMVRSLAITGEKPWDEIVINGMVFGEDGFKMSKSRGNVVEPGEITKTYGADALRLWASNSTIGKDVPFAWKEVEYGGRFLRKIWNACKFAKMNISDETISELKSLNSISIENPVDLWILSKLNNLISKVSDDLGNYKINTVVEIQKFLWHEFCDNYIEMVKHRLYNKEESESAQQEKLMAQYTLYKVITESVKLLTPFTPHFAEIVGEIYEIDDLHTSWPVSDERLISLENEFVGEVVKNTVASIRRYKSNKGMPLNAELNKVEMYVSDEKDFNAVSKASEDVKKSLKIKELEINLGKPSLEQKISEVTPNKSKIGPEFKKDAGKVMAFIKEADADTIEKMLSEGIETEFGILNKEHIKEVKRAIYNKGEIVETADIDSLIDTIAIIQ
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNJC3_BOVIN
Sequence: MVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIELKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLVKSDEMQRLRSQALDAFESSDFTAAITFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKASSKLKNDNTEAFYKISTLYYELGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIKEGRYTDAISKYESVMKTEPGVHEYTIRSKERICHCFSKDEKPVEAIRVCSEVLQVEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQRRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFSPFSSGGPFRFKFHFN
What is the function of this protein?
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress.  Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions.  Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity.  May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A (PubMed:7511204).  May inhibit EIF2AK3/PERK activity (By similarity).
What are the official names of this protein?
DnaJ homolog subfamily C member 3, Interferon-induced, double-stranded RNA-activated protein kinase inhibitor, Protein kinase inhibitor of 58 kDa, Protein kinase inhibitor p58.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: GUAA_RUMCH
Sequence: MNNEMILVLDFGGQYNQLIARRVREANVYCEVIPYNASLERIKSYNAKGIIFTGGPNSVLDEGAPKCDPGVFELGIPVLGICYGMQLMSVMLGGSVTAANQREYGKVEICVDKSQPLFRDVDENTICWMSHTYYVDTPPKGFEVIAKSANCPTGAMQHVEKNLYAVQFHPEVMHTPKGKEMLKNFLYNICGCKGDWKMSSFVENSINAIREKVGDKKVLCALSGGVDSSVAAVLIHKAIGKQLTCIFVDHGLLRKYEGDQVEQIFRKQYDINLIRVNCEDRFLQRLKGVSDPETKRKIIGEEFIRVFEDEAKKIGKVDFLVQGTIYPDVIESGIGDAAVIKSHHNVGGLPEHVDFKEIIEPLRSLFKDEVRRAGEELGIPEDLVWRQPFPGPGLAIRVIGDLTKEKLDTLRDTDYIFREEIKAAGLDKEINQYFTVLTNMRSVGVMGDERTYDYALALRAVTTTDFMTADWARIPYDILEKVSTRIVNEVKQINRIVYDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: TRMD_BORGP
Sequence: MKFTVISLFPAIIKPFFENSIMKKAINKGIVSFELIDVRDFSKDKHKRCDDLSYGGGAGMVLKAEPMSFALEHVEATKKTTIFLSPSGIKYTQELAYSLSKKEEIVIICGRYEGIDQRIIDLYVDFEISIGDYVLSSGEIAALVLIDSVYRLLDGVINPNSLLEESFGMKNGLLEYPHYTRPYNFMGIKVPEVLVSGHHENIKNWRLFKAREKTKKNRYDLYLKYLEIIGEDNGFDKKN
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.