PharMolix/UniProtQA huggingface dataset:
Protein: OBG_THEMA
Sequence: MNIERADFVDRVKIFVKAGDGGNGCVSFRREKYVPKGGPDGGDGGNGGFVFLRANPSVSTLIEFVNKRKFMAENGKHGMGKKMKGRNGKDLFIDVPVGTVVKDAVTGEVIADLNEPGKIVCVARGGRGGRGNAHFATSIKQAPLIAERGEKGESRWLELELKILADVGLVGYPNVGKSSLISRISNARPKIANYPFTTLIPNLGVVKYDDFSFVVADIPGLIEGASEGVGLGNVFLRHVERCYLIAHVIDVSGYEREDPVRDYFVIREEMKKYSPFLLEKPEIVVANKIDLIGKEELEKILKRLRDATNREVIPVSAVTGEGIDLLVSKLASIVREMKVEKPERKEEKFVKPSPVWRRLPEKFHLEVVKEDEGYWVVEGENLRVWIERFDLNQRDARLMLLQVLEKNGLNNKLKEAGVKEGDVVRIGDFEFEYRE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_BURP6
Sequence: MSLGLVGRKVGMTRIFTAEGDSIPVTVLDVSDNRVTQIKTVETDGYTAVQVAFGSRRASRVTKPLAGHLAKAGVEAGEILKEFRIEADKAAELSNGAVIGPDLFEVGQKVDVQGVSIGKGYAGTIKRYNFGSGRASHGNSRSHNVPGSIGMAQDPGRVFPGKRMTGHMGDETVTVQNLEIARIDADRKLLLVKGAVPGAKGGKVFVTPAVKTRAVKGAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RS17_POLAQ
Sequence: MTELSKPLRRTLVGRVVSDKMQKTVTVLVERQVKHPVIGKYVGQSKKYHAHDEAGTYKMGDTVEIAESKPISRTKSWVVTRLVEASKGI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PROB_HAEIN
Sequence: MNKKTIVVKFGTSTLTQGSPKLNSPHMMEIVRQIAQLHNDGFRIVIVTSGAIAAGRHYLNHPQLPPTIASKQLLAAVGQSQLIQAWEKLFAIYDIHIGQLLLTRADIEDRERFLNARDTLYALLDNHIIPVINENDAVATAEIKVGDNDNLSALVAILVQAEQLYLLTDQQGLFDSDPRKNPEAKLIPVVEQITDHIRSIAGGSGTNLGTGGMMTKIIAADVATRSGIETIIAPGNRPNVIADLAYEQNIGTKFIAHQSDRLESRKQWLFAAPSAGIITIDNGAQNAILEQNKSLLPAGIINVEGRFSRGEVVKIRTQSGKDIALGMPRYNSDALQLIKGRKSADIENVLGYEYGAVAMHRDDMIILS
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_GRAFK
Sequence: MSKVTGKVAQIIGPVVDVVFDSENAELPKIYDSLEITRKDGSILVLEVQSHIGEQTVRTVSMDSTDGLSRGVDVLATGNPIQMPVGKDVYGRLFNVIGDAIDGLGNLPKAGEDGLPIHRQAPKFEDLSVSTEVLFTGIKVIDLIEPYSKGGKIGLFGGAGVGKTVLIQELINNIAKGHGGLSVFAGVGERTREGNDLLREMLESGIIKYGDDFMHSMEEGGWDLQKVDKEVMKESKATFVFGQMNEPPGARARVALSGLTIAEYFRDGAGEGQGKDVLFFVDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGAMQERITSTKNGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRKIAELGIYPAVDPLDSTSRILTADILGDEHYDCAQRVKELLQRYKELQDIIAILGMEELSEEDKLAVSRARRVQRFLSQPFHVAEQFTGLKGVLVDIKDTIKGFNMIMDGELDKYPEAAFNLKGTIEEAIEAGEKMLAEN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HSLO_PSESM
Sequence: MHDFPDIDFTQRFIFDESDVRGELVALERSYAEVLAKHPYPEPVAQLLGELMAAAALLVGTLKFDGLLILQARSSGAVPLLMVECSSERELRGIARYDEALITPGAGLQDLMPDGSLALTVDPRQGKRYQGIVALDGVDLSESLSNYFVMSEQLGTRFWLKADGHRARGLLLQQLPAAQITDPEERDASWEHVVTLASTLTAEEMLSLDNQTVLHRLYHEDPVRLFDVQPICFRCSCSRERSANALASLGLEDAQQLVIEHNGSIEIDCQFCNERYLFDATDVAQLFAGGGVDSPSDTRH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGT_STAAN
Sequence: MKRSDRYSNSNEHFEHMKHEPHYNTYYQPVGKPPKKKKSKRILLKILLTILIIIALFIGIMYFLSTRDNVDELRKIENKSSFVSADNMPEYVKGAFISMEDERFYNHHGFDLKGTTRALFSTISDRDVQGGSTITQQVVKNYFYDNDRSFTRKVKELFVAHRVEKQYNKNEILSFYLNNIYFGDNQYTLEGAANHYFGTTVNKNSTTMSHITVLQSAILASKVNAPSVYNINNMSENFTQRVSTNLEKMKQQNYINETQYQQAMSQLNR
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation using lipid-linked disaccharide-pentapeptide as the substrate.
What are the official names of this protein?
Monofunctional glycosyltransferase, MGT, Peptidoglycan TGase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: COQ2_BOVIN
Sequence: MLGSCGAGLVRGLRAETQAWLWGTRGRSLALVHAARGLHAANWQPSPGQGPRGRPLSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCLPDWYMLSLFGTGAVLMRGAGCTINDMWDRDYDKKVTRTASRPIAAGDISTFRSFVFLGGQLTLALGVLLCLNYYSIALGAASLLLVTTYPLMKRITYWPQLALGLTFNWGALLGWSAVKGSCDPSVCLPLYFSGIMWTLIYDTIYAHQDKKDDALIGLKSTALLFREDTKKWLSGFSVAMLGALSLVGVNSGQTMPYYTALAAVGAHLAHQIYTLDINRPEDCWEKFTSNRTIGLIIFLGIVLGNLCKAKETDKTRKNIENRMEN
What is the function of this protein?
Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis.  Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate).  The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls (decaprenyl) producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9.  However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10.  Plays a central role in the biosynthesis of CoQ10.  CoQ10 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes.  CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway (By similarity).  Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (By similarity).
What are the official names of this protein?
4-hydroxybenzoate polyprenyltransferase, mitochondrial, 4-HB polyprenyltransferase, Para-hydroxybenzoate--polyprenyltransferase, PHB:PPT, PHB:polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Protein: ASSY_PELTS
Sequence: MAKVVLAYSGGLDTSVAIPWLKENYGYEVIAMSADLGQGEELAPLREKAIKSGASKIYIEDVRREFVEDYIFPTLKAGAVYEGKYLLGTSMARPLIAKKLVEIARKEGAEAVAHGATGKGNDQVRFELAVKALAPDLKIIAPWREWDIRSREDAVDYASARGIPVPVTRERPYSLDRNLWHLSHEGADLEDPGNEPPSDVLLLITPPEKAPDKPAYVKIEFERGVPVKLDGEALDPVTLIERLNKIAGENGVGIADMVENRLVGMKSRGVYETPGGTVLFLAHRELELLTLDRATLHFKEIVASRYAELVYDGMWFVPLREALDAFVDVTQRTVTGTVVMKLYKGNCTPAGVKSPYSLYDQELSTFGRDEIYNQRDAEGFINLFGLPLKVRALMEKKAGLR
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_SHISS
Sequence: MESIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQRVGAAPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKNNEKVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGENIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLEQQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGSDVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFGTLEVLEAASIEELQKVPDVGIVVASHVHNFFAEESNRNVISELLAEGVHWPAPIVINAEEIDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGIEVIDEAEMLRLLGS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: BCSC4_KOMXY
Sequence: MTRPRGPAPRDGAAWRRDPARRVLLRDAVRGREGGLRLACAVMAGLIVSGGVACAQDSHMAVAGAPATAVAPPGQPAPMPPATVADAAHLAHAAAVLELLLDQGYYWLGQHNLGKAHETIQRALSIEPDNNEALFLQGRLQMAEGGTTQATRTLERLERQGAPAGLVAQLKAQIQAGPVDPRALAEARALAASGRMMPAMFKYKALFRNGDPPPDLALEYYRVLGATILGYQEARTRLAAWVARNPRDIDARLCLDRILTYRVTSRAEGLDGLRALARSNVSAQIRSDAVAAWRDALLWEPITGQSIPLYDEWLAQHPDDTEFTIRLKKAQETQAGVDAANDRQQGYALLSRHMLDAAAREFHRAVDIDPHDPDALGGLGLVAQARQQPALARQYFLQAMQAGPDAAGHWRAALKALETGGGGVDPLVARIVQAINAGRYDAARADLATLGRRPGYGLTVLSLQAALARRQGDTADAVRLYREVVRRAPRDAGALFSLGALDVQVGDATEAADILTRLQRLAPAMARRLEAMMLSAQADRAGDDDGRIALLRRAQALDPDDPWVRLKLAHALDDAGDHAAAQAMMDALTAPRNASAQALQAGIIYAMGRHDTATAGALLERMPRTGRTPDMDRLASLVVLDQRIAALNHAPVAGNAAVLALADQPDPTGERGMRIAAALLARHAPQDARQALARGESLTQPPTPARMLAYAGTYLRLRSAFDTTRCLDAFDAMAKARPADVTADQARARQQVAIGLAIMTADGFDRYGRTAQAAQVLAPVLRAHPDSVEAHLAMGRVYQTRNMATRALEEDETALRLKPANIYALAAAARDAGGAHHLAQAKGYATRLAHEDPDGPMSWEVRSDIERIEGNSRGQLADVEHARHAQCTLDGEGECGGHESFVSDYRWPLIDSEYMDLHGATLPASYHYIPEDDGAQAMDRQIVYLRDSVSPQFDANTFVRSRTGVAGLGQLTEFAVPITATLPFESWDHRLSFSVTPTLLFTGDPLTNAVSAHQFGTVAVNGARPWGYHHYYTQGVGLSLNYVNRWFAADVGSSPLGFPITNVVGGLEFAPRLTRNLGLRISGGRRMVTDSELSYAGERDPGTGKLWGGVTRLFGHGALEWSARGWNAYAGGGFAYLGGTNVIGNTETEAGAGGSATVWQDHDRQWLRVGLDLMYFGYKRNAYFFTWGQGGYFSPRQYFGAMVPVEWSGHNRRWTWFLRGEAGYQYYHSNAAPYFPTSAQLQGQADGSPPSYYGDSGASGLAGNMRGRLVYQLDHRLRIGLEGGYSRAGSWSETSGMWMAHYTLDGQ
What is the function of this protein?
Required for maximal bacterial cellulose synthesis.
What are the official names of this protein?
Cellulose synthase 2 operon protein C.
What is the protein family that this protein belongs to?
Belongs to the AcsC/BcsC family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein.
Protein: RL20_CITBB
Sequence: MPRVKRGFKARQRRNKVLKLAKGYRGARSKLFRSATEAVDRALNYAFRDRRVKKRDFRALWITRINAAARINGLSYSKLIHGLKLANVEIDRKVMADLAVSDPNGFAAIAAAAKAKF
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: SUCC_XYLF2
Sequence: MNFHEYQAKQLFAEYGIPVPAGRIASSADEAVTAAKSLGNGPWMVKAQIHAGGRGKAGGVKFCKTTDEVKQAAATMLGTKMATYQSAGVALPVNLVLVTEAGEITKELYLSVLVDRGTRSITYIASSEGGVDIEHVAAETPEKIQTLNVDFVEGLQPYQGRDIGFHLGLEAKQVNQLSKIMISLYQLFNDKDLSLIELNPLAILSNGDLYALDGKINSDDNATFRHKELAAMRDKTQEDETEVLASENDLNYVTMDGNIGCMVNGAGLAMATMDVIKLNGGEPANFLDVGGGATKERVTTAFKLILSSNKVKAIFVNIFGGIVRCDMIAEGIIAAVKEVGVKVPVIVRLEGTNVDAGKQLLATSGLAIIPADDINDGAKKAVAAVTV
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: PHNW_VIBC3
Sequence: MKNAYLLLTPGPLSTSESVREAMLKDWCTWDDDYNLEIVEVIRRKLVTLATTQSGYTSVLMQGSGTASVEATIGSVMLPTDKLLVIDNGAYGARIAQIAQYLNIACRVIAPGETAQPNLDEIADVLTHDPAITHVAIVHCETTTGMLNPIAEVAKIAKQHGKRVILDAMSSFGGIPMDIGALGIDFMISSANKCIQGVPGFGFVIAKRSELEQCQGRARSLTLDLFDQWQCMEKNHGKWRFTSPTHTVRAFYQALLELESEGGIAARYQRYQTNQTQLVKGMRELGFAPLLPEKLHSPIITSFYSPEHSDYQFAEFYQRLKQQGFVIYPGKVSHADCFRIGNIGEVYPQDIERLLSAMQHAIYWQQA
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase, 2-aminoethylphosphonate aminotransferase, AEP transaminase, AEPT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: ROT1_CANGA
Sequence: MVRSLLFALLSVAGLVAGDAADLVGTWSSKSNQVFTGPGFYDPIDELLIEPALPGISYSFTEDGWFEEASYQVSGNPKNPACPKASLIYQHGKFELLDNGTLILHPIEVDGRQLFSDPCSDNGISTYTRYNQTEVFKSFETFIDPYHGVYTLQLYQFNGAPLPPLYLAYRPPMMLPTETLNPTDGSTGSHPTGSSESESQESDDTSKRSLLKKRSLREHVKRSLENRYKTNAVKKSDSIFNAAFVWYTSFFLVGAGSLIFISS
What is the function of this protein?
Required for normal levels of the cell wall 1,6-beta-glucan.  Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity).
What are the official names of this protein?
Protein ROT1.
What is the protein family that this protein belongs to?
Belongs to the ROT1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: Y2440_MYCBO
Sequence: MTVVVVTDTSCRLPADLREQWSIRQVPLHILLDGLDLRDGVDEIPDDIHKRHATTAGATPVELSAAYQRALADSGGDGVVAVHISSALSGTFRAAELTAAELGPAVRVIDSRSAAMGVGFAALAAGRAAAAGDELDTVARAAAAAVSRIHAFVAVARLDNLRRSGRISGAKAWLGTALALKPLLSVDDGKLVLVQRVRTVSNATAVMIDRVCQLVGDRPAALAVHHVADPAAANDVAAALAERLPACEPAMVTAMGPVLALHVGAGAVGVCVDVGASPPA
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein Mb2440c.
Protein: MSRB_METBF
Sequence: MAQKAVEKSEEEWKKVLTPEQYHVLRQKGTERPFSGNLYYNKEKGVYTCAACGQELFSSDTKFESGTGWPSFYDVISSDRVRLKEDTSYFMNRIEVVCSRCGSHLGHVFEDGPAPTGKRYCINSVSLNFKTEEEGKQGEERM
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: LSPA_LEPBP
Sequence: MKLPKTPFFSVFKPGYLAFVAFGLFLDLSSKYVIITKMYAHESIPVLGDFFRLSLTFNTGFVFGLFQDNALPSLFATGFAIVFLIFYRWENSDLGNAWGWNFVMAGAFGNFLDKFFVKIPGSGFRFGFTPEKPGIEFIGVVDFLDFEWPDFLLFDRWPAFNVADSCVSIGIVILLFTMDWKEMDKK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL9_STACT
Sequence: MKVIFTQDVKGKGKKGEVKDVPVGYANNFLFKKNVAVEATPGNLKQLQQQNKHAEQEREQEIEDAKALKKKLEDIEVEVTAKSGEGGKLFGSVSAKQIAQALQKQHDIKIDKRKMDLPNGIHALGYTNVPVKLDKEVDGTIRVHTVEQ
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ENV_JSRV
Sequence: MPKRRAGFRKGWYARQRNSLTHQMQRMTLSEPTSELPTQRQIEALMPYAWNEAHVQPPVTPTNILIMLLLLLQRVQNGAAAAFWAYIPDPPMIQSLGWDREIVPVYVNDTSLLGGKSDIHISPQQANISFYGLTTQYPMCFSYQSQHPHCIQVSADISYPRVTISGIDEKTGKKSYGNGTGPLDIPFCDKHLSIGIGIDTPWTLCRARVASVYNINNANATFLWDWAPGGTPDFPEYRGQHPPIFSVNTAPIYQTELWKLLAAFGHGNSLYLQPNISGTKYGDVGVTGFLYPRACVPYPFMLIQGHMEITLSLNIYHLNCSNCILTNCIRGVAKGEQVIIVKQPAFVMLPVEIAEAWYDETALELLQRINTALSRPKRGLSLIILGIVSLITLIATAVTACVSLAQSIQAAHTVDSLSYNVTKVMGTQEDIDKKIEDRLSALYDVVRVLGEQVQSINFRMKIQCHANYKWICVTKKPYNTSDFPWDKVKKHLQGIWFNTNLSLDLLQLHNEILDIENSPKATLNIADTVDNFLQNLFSNFPSLHSLWKTLIGLGIFVIIIAIVIFVFPCVVRGLVRDFLKMRVEMLHMKYRTMLQHRHLMELLKNKERGAAGDDP
What is the function of this protein?
The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat.  They bind to the HYAL2 receptor for cell entry.  Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated.  One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2.
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Surface protein]: Virion membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. SUBCELLULAR LOCATION: [Transmembrane protein]: Virion membrane; Single-pass type I membrane protein.
Protein: CYT1_ACTDE
Sequence: MVPKPLSLLLFLLLALSAAVVGGRKLVAAGGWRPIESLNSAEVQDVAQFAVSEHNKQANDELQYQSVVRGYTQVVAGTNYRLVIAAKDGAVVGNYEAVVWDKPWMHFRNLTSFRKV
What is the function of this protein?
Specific inhibitor of papain family cysteine proteinases.  Inhibits papain, chymopapain, bromelain, ficin, human cathepsins B, H and L, actinidain and house dustmite endopeptidase 1, but does not inhibit human bleomycin hydrolase.  Inhibits papain with an IC(50) of 2. 47 nM.  Does not inhibit cysteine proteinases belonging to other families including clostripain, streptopain and calpain.
What are the official names of this protein?
Cysteine proteinase inhibitor 1, KCPI1, Phytocystatin.
What is the protein family that this protein belongs to?
Belongs to the cystatin family. Phytocystatin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AMA1_PLAFF
Sequence: MRKLYCVLLLSAFEFTYMINFGRGQNYWEHPYQKSDVYHPINEHREHPKEYQYPLHQEHTYQQEDSGEDENTLQHAYPIDHEGAEPAPQEQNLFSSIEIVERSNYMGNPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGTQYRLPSGKCPVFGKGIIIENSNTTFLTPVATGNQYLKDGGFAFPPTEPLMSPMTLDEMRHFYKDNKYVKNLDELTLCSRHAGNMIPDNDKNSNYKYPAVYDDKDKKCHILYIAAQENNGPRYCNKDESKRNSMFCFRPAKDISFQNYTYLSKNVVDNWEKVCPRKNLQNAKFGLWVDGNCEDIPHVNEFSAIDLFECNKLVFELSASDQPKQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNTETQKCEIFNVKPTCLINNSSYIATTALSHPIEVEHNFPCSLYKNEIMKEIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKCPCDPEIVSNSTCNFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKPTYDKMKIIIASSAAVAVLATILMVYLYKRKGNAEKYDKMDEPQHYGKSNSRNDEMLDPEASFWGEEKRASHTTPVLMEKPYY
What is the function of this protein?
Involved in parasite invasion of erythrocytes.
What are the official names of this protein?
Apical membrane antigen 1, Merozoite surface antigen.
What is the protein family that this protein belongs to?
Belongs to the apicomplexan parasites AMA1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: 6PGL_HUMAN
Sequence: MAAPAPGLISVFSSSQELGAALAQLVAQRAACCLAGARARFALGLSGGSLVSMLARELPAAVAPAGPASLARWTLGFCDERLVPFDHAESTYGLYRTHLLSRLPIPESQVITINPELPVEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTGKLCWFLDEAAARLLTVPFEKHSTL
What is the function of this protein?
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6PGL.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SDC3_OPHHA
Sequence: MKTLLLTLVVVTIVCLDLGYTRKCLNTPLPLIYKTCPIGQDKCIKMTIKKLPSKYDVIRGCTDICPKSSADVVVVCCDTNKCNK
What is the function of this protein?
Acts as a beta-blocker by binding to beta-1 and beta-2 adrenergic receptors (ADRB1 and ADRB2).  It dose-dependently decreases the heart rate (bradycardia), whereas conventional cardiotoxins increases it.  At 100 mg/kg, intraperitoneal injection into mice provokes labored breathing, impaired locomotion, lack of response to external stimuli, and death (after 30 min).
What are the official names of this protein?
Beta-cardiotoxin CTX23.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Aminergic toxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ACT1_CAEEL
Sequence: MCDDEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGVVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITVGNERFRCPEAMFQPSFLGMESAGIHETSYNSIMKCDIDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin-1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HUTU_SALPB
Sequence: MPESKYRQQTIRAPRGTVLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARNWECYDAIVDALTRLEADETLLIQSGKPVGVFKTHDNAPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYNGTLAGRWVLTAGLGGMGGAQPLAATLAGACSLTIECQQSRIDFRLRTRYVDEQAATLDDALARITRYTREGKAVSVALCANAADILPELVNRGVRPDLVTDQTSAHDPLHGYLPSGWRWEEYQKNAQSDPHGTMQAAKRSMAAHVRAMLAFSQMGVPTFDYGNNIRQMAKEMGVENAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPQDIYKTDAKVKEIVAEDKHLHHWLDMARERIHFQGLPARICWVGLEWRQKLGLAFNEMVRCGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHAGMVIVCDGTDEAAARIRRVLHNDPATGVMRHADAGYDLAVECAVEQGLNLPMVAATQGKG
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.