PharMolix/UniProtQA huggingface dataset:
Protein: RL10_ALBFT
Sequence: MSLNRSEKEAVISDVTGLAAKAQTLVMAEYRGITVADMTKLRSTARSNGVSLSVLKNTLARRAVTGSGFEIVSDLMTGPLIYGFSEDAVAAARVVADFAKTNVKLVIRGGAYGGKALDVNGVKQLASIPSKEVLLAQLLGLMQSPISRTARVLAAIAEKKGAGVADAPVEAAAEAVAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: YFBV_SALPK
Sequence: MSTPDNRSVNFFSLFRRGQHYAKTWPMEKRLAPVFVENRVIRMTRYAIRFMPPVAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPSILNWFYEVRGKLQEAGQALAPVEGKPDYQALADTLKRAFKQLDKTFLDDL
What are the official names of this protein?
UPF0208 membrane protein YfbV.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ILVC_VIBVU
Sequence: MANYFNTLNLREQLDQLGRCRFMDRSEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRQAAIDEQRQSYKNAKENGFEVGSYETLIPQADLVVNLTPDKQHTNVVETVMPLMKEGAALGYSHGFNVVEEGMQIRKDLTVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAATGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKMVAEGIDPGYAGKLLQYGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADWANDDANLLGWRAETGETAFENYPSTDVEISEQEYFDNGILMVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPSVGTDVIGKGLGETSNQVDNATLIAVNETIRNHPVEYIGEELRGYMTDMKRIAVGG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: UPP_YERPG
Sequence: MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYVATADLETETVTIEGWNGPVEIEQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGVYRDEETLKPVPYFQKLVSNINERMALVVDPMLATGGSMIATIDLLKKAGCQSIKVLVLVAAPEGIKALEEAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RL7_GEODF
Sequence: MAEITKADVISFIEKMSVLELAEMVKELEEKFGVSAAAPVAVAAVAGPAAAEAAEEKTEFDVILKAAGANKIGVIKVVRALTSLGLKEAKDLVDGAPQPLKTGVSKEEAEEAKKQLVEAGAEVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: TBA1_VOLCA
Sequence: MREVISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPSDKTIGGGDDAFNTFFSETGAGKHVPRCIFLDLEPTVVDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLALDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAIYDICRRSLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNAAFEPASMMVKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTAIGEIFSRLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDFEEVGAESAEGAGEGEGEEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-1/alpha-2 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: UT2_HUMAN
Sequence: MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSHIVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFIDWVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPWTGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGMFYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIFRLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFHIEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTSWIRSSMAASGKRVSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSGILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSDKGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFFPTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYLSQERNRRASIITKYQAYDVS
What is the function of this protein?
Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.
What are the official names of this protein?
Urea transporter 2, Solute carrier family 14 member 2, Urea transporter, kidney.
What is the protein family that this protein belongs to?
Belongs to the urea transporter family.
What are the subcellular locations of this protein?
[Isoform 1]: Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: FH20_ARATH
Sequence: MALFRRFFYKKPPDRLLEISERVYVFDCCFSSDVMGEDEYKVYLGGIVAQLQDHFPEASFMVFNFREGEQRSQISDVLSQYDMTVMDYPRQYESCPLLPLEMIHHFLRSSESWLSLEGQQNVLLMHCERGGWPVLAFMLSGLLLYRKQYHGEQKTLEMVHKQAPKELLHLLSPLNPQPSQLRYLQYISRRNLGSDWPPSDTPLLLDCLILRDLPHFEGKKGCRPILRVYGQDPKARTNRSSILLFSTLKTKKHTRLYQQEECILVKLDIQCRVQGDVVLECIHLHDDLVSEEMVFRIMFHTAFVRANILMLQRDEMDILWDVKDQFPKEFKAEVLFSGADAVVPPITTSTLSDDENDFDMTSPEEFFEVEEIFSDVIDGPDHKRDSDSFVVVDTASDDSEGKEVWKGDVEPNAFLDCASDDSNHKHDMHAETSTDPVKDITVDDVQYRSDGKADSNIDSVKDIGIDDGDEQRKRRTVEAKENDSSTVQTQSKGDEESNDLESMSQKTNTSLNKPISEKPQATLRKQVGANAKPAAAGDSLKPKSKQQETQGPNVRMAKPNAVSRWIPSNKGSYKDSMHVAYPPTRINSAPASITTSLKDGKRATSPDGVIPKDAKTKYLRASVSSPDMRSRAPICSSPDSSPKETPSSLPPASPHQAPPPLPSLTSEAKTVLHSSQAVASPPPPPPPPPLPTYSHYQTSQLPPPPPPPPPFSSERPNSGTVLPPPPPPPPPFSSERPNSGTVLPPPPPPPLPFSSERPNSGTVLPPPPSPPWKSVYASALAIPAICSTSQAPTSSPTPPPPPPAYYSVGQKSSDLQTSQLPSPPPPPPPPPFASVRRNSETLLPPPPPPPPPPFASVRRNSETLLPPPPPPPPWKSLYASTFETHEACSTSSSPPPPPPPPPFSPLNTTKANDYILPPPPLPYTSIAPSPSVKILPLHGISSAPSPPVKTAPPPPPPPPFSNAHSVLSPPPPSYGSPPPPPPPPPSYGSPPPPPPPPPSYGSPPPPPPPPPGYGSPPPPPPPPPSYGSPPPPPPPPFSHVSSIPPPPPPPPMHGGAPPPPPPPPMHGGAPPPPPPPPMHGGAPPPPPPPPMHGGAPPPPPPPMFGGAQPPPPPPMRGGAPPPPPPPMRGGAPPPPPPPMRGGAPPPPPPPMHGGAPPPPPPPMRGGAPPPPPPPGGRGPGAPPPPPPPGGRAPGPPPPPGPRPPGGGPPPPPMLGARGAAVDPRGAGRGRGLPRPGFGSAAQKKSSLKPLHWVKVTRALQGSLWDELQRHGESQTPSEFDVSEIETLFSATVQKPADKSGSRRKSVGAKPEKVQLIDLRRANNTEIMLTKVKMPLPDMMAAVLAMDESVLDVDQIENLIKFCPTKEEMELLKNYTGDKTTLGKCEQYFLELMKVPRVEAKLRVFSFKFQFGTQITEFKKSLNAVNSACEEVRSSQKLKEIMKKILYLGNTLNQGTARGAAVGFKLDSLSKLSDTRAANSKMTLMHYLCKVLASKASVLLDFPKDLESLESASKIQLKSLAEEMQAIIKGLEKLNQELTASESDGPVSDVFRKTLGDFISVAETEVATVSSLYSVVGRNADALAHYFGEDPNRCPFEQVTATLLNFIRLFKKAHEENVKQAELEKKKALKEAEMEKAKGVNLTKKPVDDS
What are the official names of this protein?
Formin-like protein 20, AtFH20.
What is the protein family that this protein belongs to?
Belongs to the formin-like family. Class-II subfamily.
Protein: YR562_MIMIV
Sequence: MENTESVKVDTIDNVQNNTRSEKLAPLKPITMGSFENPSSRKQNQNDDTYEDEPNNKFSRGPEFMYSPEAGADRLSKLSQSMLDEIRKLGYDTIFRKFVDELNSDLQSQNIQKESFEDFESKWHRIVNTICNQFYRKNFGTPYEQRGRSSTRFGQNSSPNMSSELTTFIQETPVLQIIQVFIDMLQQDGNYNGKQNVDEEQIRYSRFMYRSFVTLYHKCNGTWKPQNNSENRGGNSRSNKYQRNSNRYPRNMPNRSSKSYGRTASSGRKYSQVDDETVTDTKNTYRPKPRGSYRFNKSSNFTREPERFQNSRNSSGHGRMN
What are the official names of this protein?
Uncharacterized protein R562.
Protein: PSTB_CLOTE
Sequence: MNIVKIKDLSLFYGKTHALKNINMNIEKNKVTALIGPSGCGKSTFLRSINRMNDFIENVNIDGEVIFHGKDIYKEFDEIDLRKRVGMVFQKANPFPMSIYDNVAYGPRIHGIKNKNELDIIVEKSLKKAALWDEIKDRLNKNAQGLSGGQQQRLCIARTLAVEPELILMDEPTSALDPISTSKIEELMHTLKKDYPVIIVTHNMQQAGRISDDTAFFLSGEVIEFGKTSNIFYNPQDKRTEDYISGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DHH1_CANAL
Sequence: MTDTNWKQNLNLPPKDTRPQTEDVLNTKGKSFEDFNLKRELLMGIFEAGFEKPSPIQEESIPMALAGRDILARAKNGTGKTASFIIPCLQLVKPKLNKVQALILVPTRELALQTSQVVRTLGKHVGTQCMVTTGGTSLRDDIVRLHDPVHILVGTPGRVLDLAARKVVDLSECPLFVMDEADKMLSREFKGIIEQILEFFPPNRQALLFSATFPLAVKSFMDKHLTKPYEINLMDELTLKGISQFYAFVEEKQKLHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCYYSHAKMPQQARNKVFHEFRQGKVRNLVCSDLLTRGIDIQAVNVVINFDFPKTAETYLHRIGRSGRFGHLGLAINLMSWNDRYSLYKIEQELGTEIKPIPATIDKSLYVAENADAVPRPFRIDELPKGNETVHNKGYQYKGQPVKDENSGSSSQQQQQPPPQQQQQQSTSPPQQQPQQQQQQPNPQHQFAPHPNGQFPPYPQQFHQPGAIPPQQFNGYPPYPQYPPQFAGYPGQPPQLPQGQQQHAQAQNPAQQY
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping.  Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs.  May also have a role in translation and mRNA nuclear export (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DHH1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Protein: YNEA_LISMH
Sequence: MTMKLIWDKFYVSIIFVLTCIVLGIILMCTVVGGGNDYSEVNVSEGDSLWALADQYAGKSDMAKADFVSWVEKENNLADGHVEAGESVVIPVHKTKLIKSDSTIQLANQ
What is the function of this protein?
Inhibits cell division during the SOS response.  Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and/or DivIC to the division machinery.
What are the official names of this protein?
Cell division suppressor protein YneA.
What is the protein family that this protein belongs to?
Belongs to the YneA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_STRPB
Sequence: MTKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLIELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTSVRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQALVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFIERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGYTLAQVPYIKAILESFDSPCVDKLVNDIDSLPELEYLIRTAIDPDAPATISEGSIIRTGFDERLDHYRKVMREGTGWIADIEAKERQESGINNLKIDYNKKDGYYFHVTNSNLSLVPEHFFRKATLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKTLATVDVLQSLAVVAETNHYIRPQFNDNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDAIFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHELTDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIMSVPPQVESSSAVRQGQLSLFGDDEKAHEIRQALEAIDVMNMTPFQAMTTLYELKKLL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: PTPJ3_MDBVW
Sequence: MTTQPDSMSAIDFLIFMEHPVSLSSIADEYYTIVPRQEVKALSSSNQTMNEEQEHSCMRIIRFLHCRVKLSGNRNVLNANYVDGYEHKRKYIYTKSPCANNVDEYLQMMWDKNVEIIVVPSRSENDVNFHQYWSPNEGAVIEYDNFKIETLEVTTKPQYILTLLILTNRKGRIHRISHFEYTAWPVYSICHDLRAFLDFVSNINEQYTYLEKHKPSRQTRSYNCAFASMVTIAQQYFVYLIPVLQNSKRRE
What are the official names of this protein?
Tyrosine phosphatase-like protein J3, PTP-J3.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: PTFBC_VIBCH
Sequence: MKMKIAIVTACPSGVANSIIAAGLLQQASKTLGWEAYIECHSTVIAGHTLSEEEINKADLVILAANGKIDMQRFVGKKVYQSPITACTSDPVGYLKQAAEQATELSSEQATRCDSPATASVSAKKIVAITACPTGVAHTFMAAEALEAEATRQGHQIKVETRGSVGAKNQLTEQEIAAADLVIIAADIDVPLDRFNGKKLYKTSTGLTLKKTAQELSNAFAQAKTFSSSANSATNEKAEEKKGVYKHLMTGVSHMLPVVVAGGLIIALSFVFGIEAFKEEGTLAAALMQIGGGSAFALMIPVLAGYIAFSIADRPGLAPGLIGGMLASSTGAGFLGGIVAGFLAGYSAKFIADKVQLPQSMAALKPILIIPFIASLFTGLVMIYVVGGPMSSIMSGMTSFLNNMGSTNAILLGIVLGAMMCFDLGGPVNKAAYTFGVGLLASQTYAPMAAIMAAGMVPALGMGLATFIAKDKFEAGEREAGKASFVLGLCFISEGAIPFAAKDPMRVIPACMVGGAVTGALSMLFGAKLMAPHGGLFVLLIPNAISPVLLYLVAIAVGTAITGFGYAMLKKSAQAKAVAA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II FruAB PTS system is involved in fructose transport.
What are the official names of this protein?
PTS system fructose-specific EIIB'BC component.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RRAAH_YEAST
Sequence: MSDLQKLQRFSTCDISDGLLNVYNIPTGGYFPNLTAISPPQNSSIVGTAYTVLFAPIDDPRPAVNYIDSVPPNSILVLALEPHLQSQFHPFIKITQAMYGGLMSTRAQYLKSNGTVVFGRIRDVDEHRTLNHPVFAYGVGSCAPKAVVKAVGTNVQLKILTSDGVTQTICPGDYIAGDNNGIVRIPVQETDISKLVTYIEKSIEVDLLVSEDIKNGIPAKQAQNDRRSVLKKYI
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
What are the official names of this protein?
4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: VE7_BPV4
Sequence: MKGQNVTLQDIAIELEDTISPINLHCEEEIETEEVDTPNPFAITATCYACEQVLRLAVVTSTEGIHQLQQLLFDNLFLLCAACSKQVFCNRRPERNGP
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: RL5_BORT9
Sequence: MSYVPALKKHYKDNIIKELVSEFQYKSIMQAPKIEKIIVSMGVGDAVKNKKLLDSAVYELSQITGQRAVKTKAKKAIAGFKIRQGQEIGAKVTLRGNIMYEFLYKLINLALPRVKDFRGVNGNAFDGNGNYSFGIAEQIIFSEIDYDKIERISGLNVTIVTTALNDREGKALLSKFGMPFSN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RS8_HELPY
Sequence: MVNDIIADSLTRLRNASMRRLEFTQLYYAKIVVSILEIFKEKGFIKDFNVKDKDKKQSVYVQLAYDEKGHSKISEVKRLSKPGRRVYKQKNELKRFKNGYGVIVVSTSKGVITNEEAYRQNVGGEVLCSIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RS7_PEDPA
Sequence: MPRKGPAPKREVLPDPIYNSKLVTRLINRLMLDGKRGKASKILYNAFDIIEKETGSEPTGVFEEAMNNIMPVLEVKARRVGGSNYQVPIEVRPDRRTTLGLRWLVNYARLRGEHTMPERLAREIMDAANNTGASVKKREDTHKMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Y412_SYNY3
Sequence: MPLPLMMINYSLLLSLALPPIAGGIIGYFTNDLAIKMLFRPYKPLFLGPYQLPFTPGLIPRNQERLAKRVSDTIMGSLLTPEELQRLARKLLQRERVEGALGWLLQLALKQIREDKQQKTAQILANILRDLFSESLPRLLKALARQDNFLSDQINRIFDQILLEFRLSELQSRQFADWLLGTVLPPDTIRLALVDFLSDRNIQVIDEGFREKTSGTYWVVANLFGVRNSLTRLRAFCLEEKETANLRLKELLLSLEIRNRLKDWLQQLSLENLPVSTVRQLRRTTGEVVRTYIRERGEPLLKDFGSSVDWDNVAVLIVNRLQSSTAVTGSLGLVSEELASILERYLEDDLEKIVKQIIPILAIDQVIINRINETPAAELETAVQAIVRSELQAIVNLGGVLGLIIGGLQTGFFLVSRGF
What are the official names of this protein?
UPF0754 thylakoid membrane protein sll0412.
What is the protein family that this protein belongs to?
Belongs to the UPF0754 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: KRA54_MOUSE
Sequence: MTCCGCSGGCGSSCGGCGSSCCKPVCCCVPVCSCSSCGGCKGGCGSCGGCKGGCGSCGGCKGGCGSCGGCKGGCCQSSCCKPCCCQSSCCKPCCSSGCGSSCCQSSCCKPCCCQSSCCKPCCSSGCGSSCCQSSCCKPCCCQSSCCKPCCCQSSCCKPCCSSGCGSSCCQSSCCKPCCCQSSCCKPCCCQSSCCKPCCCQSSCCKPCCCQSSCCAPVCCQCKI
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 5-4, Ultra high sulfur serine protein 2, UHS-Ser-2.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 5 family.
Protein: FCGR2_RAT
Sequence: MDSNRTVVHVLSRTLYHMLLWTAVLNLVAESHAGLPKAVVKLEPPWIQVLKEDTVTLMCEGTHNTKNCSTQWFHNGSSIWHQAQANYTFKATVNDSGEYRCRMEETGISEPIHLGVISDWLLLQTSQLVFEEGETITLRCHSWKNKQLTKVLLFQNGKPVRYYHQSSNFSIPKANHSHSGNYYCKAYLGRTMHVSKPVTITVQEPKSSSSLPVLTIVAAVAGIAVAAIVIILVSLVYLKKKQVPDTPSGLEEAEKNEVENTITYSLLKHPEAPDEESDHDYQNHI
What is the function of this protein?
Binds to the Fc region of immunoglobulins gamma.  Low affinity receptor.  By binding to IgG it initiates cellular responses against pathogens and soluble antigens.
What are the official names of this protein?
Low affinity immunoglobulin gamma Fc region receptor II, Fc-gamma RII, FcRII, IgG Fc receptor II beta.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ECOT_ECO81
Sequence: MKTILPAVLFAAFATTSAWAAESVQPLEKIAPYPQAEKGMKRQVIQLTPQEDESTLKVELLIGQTLEVDCNLHRLGGKLESKTLEGWGYDYYVFDKVSSPVSTMMACPDGKKEKKFVTAYLGDAGMLRYNSKLPIVVYTPDNVDVKYRVWKAEEKIDNAVVR
What is the function of this protein?
General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
What are the official names of this protein?
Ecotin.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PSTA_DICDI
Sequence: MNKIYLILILFTFVGIILANVEKAEVSCTCDENCNDGNKCTLDKCNNGCCSNTPININDNDECTVDTCNPKTGISHTPVNCDDGNSCTADSCLCGKGCQHVPIACDDNNACTVDSCSNSTGCCHTPLSCDDNNPCTVDSCSNSTGCCHTPINVDDHNACTEDKCTQSGGVTHTPIACDDKNACTVDSCSNSTGCCHTPLSCDDNNACTVDSCSNSTGCVHTPINVDDHNACTEDKCTQSGGVTHTPIACDDKNACTADSCSNSTGCCHTPITCDDNNACTVDSCSNSTGCCHTPINVDDNNACTEDKCTQSGGVTHTPIACDDKNACTVDSCSNSTGCVHTPLACDDKNPCTVDSCSNSTGCCHTPINVDDNNACTEDKCTQSGGVTHTPINCDDNNKCTVDSCSNSTGCCHTPMSCDDNNPCTVDSCSNSTGCVHTPINVDDNNACTEDKCTQNGGVTHTPIACDDKNACTVDSCSNSTGCCHTPLKCDDNNACTVDSCSNSTGCVHTPINVDDNNACTEDKCTQSGGVTHTPISCDDKNPCTIDSCSNSTGCVHTPMSCDDRNPCTSDFCSWEKGCQHVALSCNDFNACTMDSCSNSTGCTHTPIACDDKNACTVDSCSNSTGCVHTPLTCDDNNPCTVDSCSNSTGCCHTPINVDDHNACTEDKCTQSGGVTHTPIACDDKNACTVDSCSNSTGCCHTPLSCDDNNACTVDSCSNSTGCVHTPINVDDNNACTEDKCTQNGGVTHTPIACDDKNACTVDSCSNSTGCCHTPLKCDDNNPCTVDSCSNSTGCVHTPMNVDDNNACTEDKCTQNGGVTHTPIRCDDLNSCTADSCSNSTGCVHTPINCDDNNKCTADSCSNSTGCCHTPISCDDNNPCTVDSCSNSTGCCHTPINVDDNNPCTEDKCTQSGGVTHTPIGCNDNNACTVDSCSNSTGCTHTPMKCDDNNPCTIDSCSNSTGCVHTPMNCDDGNFCTLDSCCSTGCTHTPIIIDDNNPCTVDSCCNSTGVVHTPVDCNDNNVLTCDYCSIKQGGKCIHVPMTQCKTFGKCGDDL
What is the function of this protein?
Component of the stalk tube, the matrix that encases stalk cells.
What are the official names of this protein?
Prestalk protein, Extracellular matrix protein ST310.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PQQD_RHIME
Sequence: MTADAPVISGSSVVKLARGVRLHEDPVRGQTVLLAPERAMAVDDIAVAIVQALDGERNLDRIAADFAEKFDAPVEEIAEDVRTFVQELSVRRMLEIVQ
What is the function of this protein?
Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
What are the official names of this protein?
PqqA binding protein, Coenzyme PQQ synthesis protein D, Pyrroloquinoline quinone biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the PqqD family.