PharMolix/UniProtQA huggingface dataset:
Protein: GLIT_ASPFU
Sequence: MSIGKLLSNGALLVDVLIIGAGPAGLSTATGLARQLHTAVVFDSGVYRNAKTQHMHNVLGWDHRNPAELRAAGRADLTTRYSTIQFQNSTIEAIRQVETNQLFEARDNEGHSWYGRKVVLATGVRDIPLDIEGYSECWANGIYHCLFCDGYEERGQETVGVLALGPIANPARALHLARMALRLSESVTIYTNGNEQLAKEIQQAAEESPVGASGLKFEARPIRRFEKGDVAKTVIVHLGESESKTEGFLVYNPQTEVNGPFAKQLALNMTEGGDILTTPPFYETSVPGVFAVGDCATPLKAVTPAVSMGSLAAGGLVAQLQAQALPEFRLDQEL
What is the function of this protein?
Thioredoxin reductase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide (PubMed:15979823, PubMed:21612254).  The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP (PubMed:17154540, PubMed:21612254).  GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp (PubMed:23434416).  The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain (PubMed:24039048, PubMed:23434416).  The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin (PubMed:21513890, PubMed:21749092).  This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties (PubMed:22903976, PubMed:24039048).  Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure (PubMed:20548963, PubMed:22936680, PubMed:24039048, PubMed:25062268).  GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides (PubMed:25062268).  Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA (PubMed:26150413).  GliT is required for self-protection against gliotoxin (PubMed:20548963, PubMed:26150413).  GliT plays a role in preventing dysregulation of the methyl/methionine cycle to control intracellular S-adenosylmethionine (SAM) depletion and S-adenosylhomocysteine (SAH) homeostasis during gliotoxin biosynthesis and exposure (PubMed:26150413).
What are the official names of this protein?
Thioredoxin reductase gliT, Gliotoxin biosynthesis protein T.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
Protein: PFA3_NEUCR
Sequence: MDATPYTTSSTSTALDSPSSLSATMARRWARKLERYCCTCVTYFPLAFVYSMTSWAAYVDVSLSTTPSRVTWLGHSYGFIAVVLYLLANWCYTYAVFTSPGSTTNEYGYSTLPTQAPPTATSFTVKSNGEFRFCKKCQARKPDRAHHCSTCRRCVLKMDHHCPWLATCVGLRNHKAFLLFLIYTSVFCWVSFAGSASWVWEEIMSNTTYVETLMPVNYIMLSVISGIIGIVLSAFCGWHIYLASRGQTTIECLEKTRYLSPLRESMQRTYVNQHTPGQGIALPKYGQQLLDIHQNTIPGVTRPEEGEEMRRMTTPSGSSQRNDLASQHNPELQAGSRRFTYDEMEHIRARKRYEDYLDEQDSTKLPHAFDLGTPRNLLHLFGTNAWLWPFPVCTTIGDGWSWEPNPKWIEARDRIAREREEQRQRERQAGWGPADDDDITPVYTPTWTPPNQQHPQGGAGRHYLQPSSQPQTQRNSNSSSPSFTPSRRTPSKADRILGRDPNMYADDEPVIYGKHDVAMSRLSPAGRTLVVEDDVLNDDDDDDEDYFQDAGRKQEDAEQSALNVVTNGRWGRPAGASGVGLLAHGRPGGARSPISPISPPARGFGGSAKNGEEGRSNDDGVD
What is the function of this protein?
Palmitoyltransferase specific for vac8.  Palmitoylates vac8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).
What are the official names of this protein?
Palmitoyltransferase pfa3, Palmitoyltransferase 3, Protein fatty acyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: YD87C_YEAST
Sequence: MKRCACLSNSPTRHTTVVVPSPVISSCAAAALAISTAVGDWICISVSNTLPSLVSLMLPAPSTSIFSVPLGPKLVSRTDCKPSADVTLTFKAASLLNDSAFGFNNCNDMLLLYLYYNLLLLTASTPLTFTFSTHCTHTLLYIILSVFRSFLTRITTTNTSPSENFATKAKLP
What are the official names of this protein?
Putative uncharacterized membrane protein YDR187C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS16_FINM2
Sequence: MSVKIRLKRMGAKKKPFYRIVVADSRCPRDGKFIEEIGYYNPLVEEKTVKVDSEKVQQWIKNGAKPTDTVDRLFKNNGVYEAK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RISB_MYCUA
Sequence: MSGGAGIPDVPAFDASGVRLAIVASTWHTKICDALLAGARNTAADSGIDNPTVVRVLGAIEIPVVAQELTRNHDAVVALGVVIRGETPHFDYVCDVVTQGLTRVSLDSSTPVANGVLTTNSEEQALNRAGLPTSDEDKGAQATAAALTTALTLRELRAES
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: PUR9_CORDI
Sequence: MSDDRKQIKRALISVYDKTGLEDLARALNDAGVEIVSTGSTAAKIADLGVPVTPVEQLTGFPECLEGRVKTLHPMVHAGILADTRKEDHLKQLDELNVAPFQLVVVNLYPFTQTVASGADFDACVEQIDIGGPSMVRAAAKNHPSVAVVVSPSRYSEIIAAVGNGGFTRAERTALAVDAFRHTASYDVAVATWMGEQIADADKPFAEWIGASYERANILRYGENPHQAAALYTDPAAPAGLAQATQLHGKEMSYNNYTDSDAAWRAAWDHERPCVAIIKHANPCGIAVSDVSIAEAHRTAHACDPVSAFGGVIASNREVSVDMAKQVSEIFTEVIIAPSYEDGAVDILSQKKNIRILVAPQPQRDELEQRQISGGVLVQRRDLVDAEGDTPANWTLAAGEGASEELLAELEFAWRAVRAVKSNAILLAQGGATVGVGMGQVNRVDAAKLAVERANSLAGDEQRAKGSVAASDAFFPFADGFEVLAQAGVRAVVQPGGSIRDAEVIEAANKAGVTMYLTGARHFAH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: RLME_FRATT
Sequence: MSKGSSTKKWLHEHTSDYYVIQANKLGYRSRASFKILEIQDKYQLFKPNMFVVDLGAAPGGWSEQVIKYIGKNGKLIALDLLEMAPIAGVEFIQGDFSSDETYQKLNTLVNNQKIDCVISDMAPNLSGNKTSDQAKSIYLLELALDFANTNLNKNGSFVAKVFQGQGSDEYLKLVRESFNKVIQFKPKSSRAKSREFYVIATEFKG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_OENOB
Sequence: MKLDRRLVIKILEEKIKSEGIVLGSDILKVNSFLNHQIDPFLMSQIGQAFAEKFSHENISKVLTIESSGIAPALMTSLQLQVPMIFARKHQSRTLNEEFFSASVYSYTKQTENQIAVSKRFINPGDRVLIIDDFLANGQAVQGLLDIINQAGASAVGVGIVIEKRFQAGHQLILSKNLPLVSLASIDRFEDGQVVFSKQGETSHVN
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_HASV6
Sequence: MASKSDKQVTVEVNNTGRGRSKSRARSQSRGRGRSVKITVNSQNKGRRQNGRNKRQSNQRVRNIVNKQLRKQGVTGPKPAICQKATATLGTIGSNTSGTTEIEACILLNPVLVEDATGSTQFGPVQALGAQYSMWKLKYLNVRLTSMVGASAVNGTVVRVSLNPTSTPSSTSWSGLGARKHLDVTVGKNAIFKLKPSDLGGPRDGWWLTNTNDNASDTLGPSVEIHTLGRTMSSYQNQQFTGGLFLVELASEWCFTGYAANPNLVNLVKSTDKQVNVTFEGSAGTPLVMNVPAASHFARTVAQRSTLPTSMARAGENTASDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRVRNGNRSFYVYASYQDALSNKPALCTGSTSGSMRTRPAVMTTLQFTQMNQPSLGHGETPATLGRSIPTSGETLKVLLTVGNPISPNETNKQTWVNKTIEPPGAVVRIGRDTQHYCTLNGFTLITKVDWFTEEFQPSEEPAPVQGLMVLGDNHKKADVYAAQQYKNPITNDKQEVTSVFLVRVNEGFQVTNHLSYFYRNSVNTDAVENIKIRSATRHTTVRFYQGSWYLLTSTVLHTGPPVSGWLWMNQELQNDQAYIIDQGIMHLITPPPVSSQIYFEMATLVPQTRSGGGETGLELVMGLSDDEYPISHVNDEEETEYETESDEDETDEVDRFDLCCTSDSEDDIENNRVTLLSTLINQGVTVDRATMITNRAFPTPNYKPRREPSNDLLAPSDCLATARSHACNETCQLSGSRGHAE
What is the function of this protein?
The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions.  This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry.  The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34.  This forms contains only 30 spikes located on the icosahedral 2-fold axes.  Plays a role in the attachment to target host cell.  This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).
What are the official names of this protein?
Capsid polyprotein VP90.
What is the protein family that this protein belongs to?
Belongs to the astroviridae capsid polyprotein family.
What are the subcellular locations of this protein?
Virion.
Protein: VM2CO_AGKCO
Sequence: MIQVLLVTLCLAAFPYQGSSIILESGNVNDYEVLYPQKVTALPKGAVQPKYEDTMQYEFKVNGEPVVLHLEKNKGLFSKDYSETHYSSDGRKITTNPPVEDHCYYHGRIQNDADSTASISACNGLKGHFKLQGETYLIEPLKLSDSEAHAVYKYENVEKEDEAPKMCGVTQTNWESDEPIKKASQLNLTPEQQGFPQRYIELVVVADHRMFTKYNGNLNTIRIWVHELVNTMNVFYRPLNIRVSLTDLEVWSDQDLINVQPAAADTLEAFGDWRETVLLNRISHDNAQLLTAIELDGETIGLANRGTMCDPKLSTGIVQDHSAINLWVAVTMAHEMGHNLGISHDGNQCHCDANSCIMSEELREQLSFEFSDCSQNQYQTYLTDHNPQCMLNEPLRTDIVSTPVSGNELLETGEESDFDAPANPCCDAATCKLTTGSQCADGLCCDQCKFMKEGTVCRRARGDDLDDYCNGISAGCPRNPFHA
What is the function of this protein?
Inhibits ADP-induced platelet aggregation.  Binds and inhibits integrins GPIIb/GPIIIa (ITGA2B/ITGB3), alpha-5/beta-1 (ITGA5/ITGB1), alpha-V/beta-3 (ITGAV/ITGB3), and alpha-V/beta-5 (ITGAV/ITGB5).  It blocks cancer cell adhesion (tested on human breast cancer cell line MDA-MB-435) to fibronectin and vitronectin and thus prevents invasion of cancer cells.
What are the official names of this protein?
Zinc metalloproteinase/disintegrin.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IId sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMH_RHILW
Sequence: MVANPGGGSTDAGGGPVRHIPVLLDEVLSALAPAPGKLILDGTFGAGGYSSAILAAGAEVIALDRDPTAIASGQAMVAAHGGRLKLVHSQFSHLADHAPQGGLDGVVLDIGVSSMQIDEAERGFSFQKNGPLDMRMSAAGVSAADVVNRAKVADLIRIFHFLGEESQAPRIAHAIEKRREEKPFETTRDLAGLIELVTPRKMKDKIHPATRVFQALRIFVNDELGELAQALFAAEAALKPGGRLVVVTFHSLEDRIVKKFFSDRAGKASGSRHLPVAHERAATFAAIGKPMVSASEAEAEINPRARSAKLRAGLRTEAAAEAADMSLFGFPNLASLGKLGG
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIV_MORLA
Sequence: MSKTYIGIDIAKNTFDACFITHNTWQNCTFTNNQQGFIELTLWIQAHHYNTSTLHLIIEATGAYWEKLAHWAISHHHKVSIVNPLYIHAYAKSLGIRTKTDKQDAILLARYGAKENPPLWQPKSDNEIKLTALLKQREHHKRQLIKERTRQEALSIYVKSYTDDNIRHWSDSITQLDHQIWQLINCTPELNYRASLLATIPGIGKKTLPHLLVVIGDGSSFQSAKHLASYAGLAPRHHQSGISIHKQSSIGFSGQKELRSALFMPAVIVSFGRYPAFQKFVKRMEQKGKTKKQIIIAIMRKLLTISYAVIRQNRPFDKRIHE
What is the function of this protein?
May be the site-specific invertase required for pilin gene inversion.  Moraxella can express either a Q or I pilin; the inversion of 2 kb of DNA determines which pilin is expressed.
What are the official names of this protein?
Pilin gene-inverting protein, PIVML.
Protein: RIMP_GEODF
Sequence: MAKVDVVSRVTELAEQVLSSLGMELVELEYKHEGRELVLRLFIDKEGGVTLDDCESVSRDLSQILEVEDIITGHYRFEVSSPGLDRPLKKGSDYEKYAGRLVKIRTFEALADDAGNKRKTFLGELKGLKEGQVHIALKEGQSAVIPLDKIAKANLEFEF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_MOUSE
Sequence: MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNPNARLRSEENE
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
60S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_CELJU
Sequence: MPWLQLKVIAPRRYVESIENALLAAGAASVTLQDNADQPIFEPGLGETPLWDNVKITGLFDAEIDTAKAIALAERRFGNPLPQHQWEQLEDKDWEREWMSNYHAIRCGERLWICPSWQEPPEPDKINLMLDPGLAFGTGTHPTTFLCMQWIDQQDFTDLEVIDYGCGSGILGIAALLLGARKVVGVDIDPQALLATTENAKRNQLPADAMPVYLPPHCPATQVDVMLANILAGPLAELAPTLSNMTKPGGKLCLSGILSVQAQSVMDAYAPWFDFDPVATHEEWVRLTAIKARA
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DB126_HUMAN
Sequence: MKSLLFTLAVFMLLAQLVSGNWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPADRRANYPVFCVQTKTTRISTVTATTATTTLMMTTASMSSMAPTPVSPTG
What is the function of this protein?
Highly glycosylated atypical beta-defensin involved in several aspects of sperm function.  Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx.  Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation.  Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity).  In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (PubMed:19373462, PubMed:23229569).
What are the official names of this protein?
Beta-defensin 126, Beta-defensin 26, DEFB-26, Defensin, beta 126, Epididymal secretory protein 13.2, ESP13.2, HBD26.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted by epididymal cells and is absorbed to the surface of sperm during transit through the epididymis (By similarity). Mainly located on the sperm acrosome.
Protein: PYRR_PSEPG
Sequence: MSLPNPAELIRQMAVDLRAHLARRHISEPRYIGIRTGGVWVAQALQEAMGDTSPMGTLDVSFYRDDFSQNGLHPQVRPSELPFEVEGQHLVLVDDVLMSGRTIRAALNELFDYGRPASVTLVCLLDLDAGELPIRPNVLGATLSLAAHERVKLTGPAPLALERQDLASASAL
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: YN8Z_YEAST
Sequence: MLKLTTTSVTFHVLRYFQLGLSVTNLLLASFAIITNYKVDRILRLSLAVSIISSVYFGIVRFLPVLLIFVMEIVQTVLWFTAFVTLASKFGSMSCSSMPRGINFDYSGSCKIAKIDILPEAVLFILFLATTYASYITVLSQAKENGSSTRSVLKACVKALRDTVDRLETSLEESEPLLDLEVQEDARTETESIEDSTDSEDNANIEQEKVIDGSIEHSS
What are the official names of this protein?
Uncharacterized vacuolar membrane protein YNR061C.
Protein: HEM6_SODGM
Sequence: MDQPDIEHINAYLLALQETICAALTAADGGAVFHEDLWQRDEGGGGRTRVLRQGRVFEQAGVNFSRVYGGALPASATAHRPELAGRSYQAMGVSLVVHPENPYIPTSHANVRFFIAEKPGAEPIWWFGGGFDLTPFYGFHEDAVHWHRTAQALCQPFGDTVYPRYKRWCDDYFFLKHRNEARGIGGLFFDDLSAPNFNEAFAFCRAVSQGYLDAYLPIVERRKSHPWGERERQFQLYRRGRYVEFNLVWDRGTLFGLQSGGRTESVLMSMPPLARWQYHYDPAHDSPEAALYRDFLPARDWLKE
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSD_STAA9
Sequence: MKKSAVLNEHISKAIATIGHFDLLTINDAGMPIPNDHRRIDLAVTKNLPRFIDVLATVLEEMEIQKIYLAEEIKEHNPTQLQQIKQLISSEIEIIFIPHEEMKSNLAHPLNKGNIRTGETTPYSNIALESNVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS2_CHLAD
Sequence: MSVYNPNDADFAFTIGIEEEYQIVDPETRELRSYITQILEPGRTILREQIKPEMHQSIVEVGTRPCRTISEARAEIVRLRGAIAGLAARHNLRIVAAGTHPFSSWMQQEITPDERYRMVVGEMQEAALQLLIFGMHCHIGMPNNEVAIELMNVARYICPHLLALSTSSPFWMGRNTGFKSYRSVIFSTFPRTGIPPTFHSASEFERYVQLLINTGCIDNGKKIWWDLRPHPFFGTLEFRVCDIATKVEECLALAATMQALIVKFYTMFEENTTFRVYRRALINENKWRAQRWGLDGKLIDFGKRKEVEAKALVHEIVELVDDVVDMLGSRKEVEYLLTIVDQGTSADRQLRVFAETNDLKAVVDSLMNETIEGVPVMTFDTESSVQTAHS
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: LY66D_RAT
Sequence: MNSQLIGILFSALLGAALGQRMRCYDCGGGPSNSCKQTVITCGEGERCGFLDRKPQPSSEQAKQPSATLSHHYPACVATHHCNQVAIESVGDVTFTTQKNCCFGDLCNGAVASSSTPLCILAAVTTLAWLLSGQ
What are the official names of this protein?
Lymphocyte antigen 6 complex locus protein G6d.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: T96_TERAN
Sequence: MMSKTGALLLTFMILVLFSMAAADALGERFEDHEQKIREQDAGVGLLSLMGRAVIECSKCDTDCKTQKGCIPVAKTTNNPTYCIC
What are the official names of this protein?
Teretoxin Tan9.6.
What are the subcellular locations of this protein?
Secreted.
Protein: TRHO_SALCH
Sequence: MPVLHNRISNDELKAKMLAESEPRTTISFYKYFTIASPQQTRDALYQVFTALDVFGRVYLAHEGINAQISVPQSKLETFRQQLYTFDPALDGLRLNIALEDDGKSFWVLRMKVRDRIVADGIDDPSFDASNVGDYLKAADVNVMLDDPDAVFIDMRNHYEYEVGHFENALEIPADTFREQLPKAVEMLREHADKKIVMYCTGGIRCEKASAWMKHNGFNKVWHIEGGIIEYARRAREQGLPVRFIGKNFVFDERMGERISDEVIAHCHQCGASCDSHTNCKNDGCHLLFIQCPQCASKFNGCCSEQCCEELALPEEEQRRRRAGRENGNKIFNKSRGRLNSKLSIPDPAE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: CYB_LEITA
Sequence: MFFRVRFLLFFLLFRNLCCLLTSGCLLRVYGVGFSLGFFICMQIICGVCLAWLFFSCFICTNWYFVLFLWDFDLGFVIRSTHICFTSLLFFLLYVHIFKCIVLIILFDTHILVWAVGFIIYIFIVVIGFIGYVLPCTMMSYWGLTVFSNILATVPVIGTWLCYWIWGSEYINDFTLLKLHVLHVLLPFVLILVIFMHLFCLHYFMSSDGFCDRFAFYCERLCFCMWFYLRDMFLAFLILFYVVYFIFINWYFVFHEESWVIVDTLKTSDKILPEWFFLFLFGFLKAVPDKFTGLLLMVILLFSLFLFILNCILWFVYCRSSLLWFTYSLILFYSIFMSGFLALYVILAYPIWMELQFWVLLLFMLVVCRLD
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UNG_STRPB
Sequence: MAHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNPKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDPR_HUMAN
Sequence: MMFYRLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQVVICGGGITGTSVAYHLSKMGWKDIVLLEQGRLAAGSTRFCAGILSTARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYELGLSNEEPVSIPLHACEHFYLLTRPLETPLQSSTPTIVDADGRIYIRNWQGGILSGGFEKNPKPIFTEGKNQLEIQNLQEDWDHFEPLLSSLLRRMPELETLEIMKLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVPPDKDLLALEQSKTFYKPDWFDIVESEVKCCKEAVCVIDMSSFTKFEITSTGDQALEVLQYLFSNDLDVPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNLLLEDVTWKYTALNLIGPRAVDVLSELSYAPMTPDHFPSLFCKEMSVGYANGIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGMDFIGRDALLQQKQNGVYKRLTMFILDDHDSDLDLWPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEEQVVTADFINRGEYEIDIAGYRFQAKAKLYPVASLFTQKRRKDDMELSDLHGK
What is the function of this protein?
Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.
What are the official names of this protein?
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial, PDPr.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
What are the subcellular locations of this protein?
Mitochondrion matrix.