PharMolix/UniProtQA huggingface dataset:
Protein: PA2_AUSSU
Sequence: NLIQFANMIGCANHGSR
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits collagen-, ADP-, thrombin-, ionophore-, adrenaline-, ristocetin-, and arachidonic acid-induced platelet aggregation.  Inhibits serotonin release.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AV2_TYCSV
Sequence: MWDPLLNEFPDSVHGLRCMLAIKYLQLVEETYEPNTLGHDLIRDLISVIRARDYAEANRRYTNFNARLEGSSKTELRQPVYQPCCCPHCPRHQASIMDLQAHVSKAADVQNVQKP
What is the function of this protein?
Through its interaction with host SGS3, acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.
What are the official names of this protein?
Protein V2.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae protein AV2/V2 family.
What are the subcellular locations of this protein?
Host cytoplasm, host perinuclear region. Note=Accumulates in inclusion bodies in the cell periphery. May interact with the ER network from the perinuclear region out to the cell periphery (By similarity).
Protein: CR3L4_HUMAN
Sequence: MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHCPPPEVPVTRLQEQGLQGWKSGGDRGCGLQESEPEDFLKLFIDPNEVYCSEASPGSDSGISEDPCHPDSPPAPRATSSPMLYEVVYEAGALERMQGETGPNVGLISIQLDQWSPAFMVPDSCMVSELPFDAHAHILPRAGTVAPVPCTTLLPCQTLFLTDEEKRLLGQEGVSLPSHLPLTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLILLFSLALIILPSFSPFQSRPEAGSEDYQPHGVTSRNILTHKDVTENLETQVVESRLREPPGAKDANGSTRTLLEKMGGKPRPSGRIRSVLHADEM
What is the function of this protein?
Transcriptional activator that may play a role in the unfolded protein response.  Binds to the UPR element (UPRE) but not to CRE element.  Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE.  Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3-like protein 4, cAMP-responsive element-binding protein 3-like protein 4, Androgen-induced basic leucine zipper protein, AIbZIP, Attaching to CRE-like 1, ATCE1, Cyclic AMP-responsive element-binding protein 4, CREB-4, cAMP-responsive element-binding protein 4, Transcript induced in spermiogenesis protein 40, Tisp40, hJAL.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single- pass type II membrane protein. Note=May also be located in Golgi apparatus. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 4]: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus.
Protein: RLMN_BACC3
Sequence: METTVRKQKKNLETKKPSIYSLQLHEMQDWLKEQGEPKFRAGQIFDWLYKKRVKNYEDMSNLSKGLREKLSNSFDITTLNTLVKQTSSDGTIKFLFQLYDGYSIETVLMRHEYGNSICVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVEVQRALDESEERVSSLVVMGIGEPFDNYDNLMGFLRIINHEKGLHIGARHMTVSTSGIIPKIYKFAEEDLQINFAISLHAPNSELRSKLMPINRAYKLPDLMEAIKYYVNRTGRRITFEYGLFGGENDQVEHAEELAALLKGVKCHVNLIPVNYVPERDYVRTPREQIFLFEKTLKDRGVNVTIRREQGHDIDAACGQLRAKERKEETR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_THEVO
Sequence: MYSPSSSNYIKDPISTEIIKSKTRNLKKRAEEAILYRSIAEQSSRKLAEISEAYKHKLADMENYLKIKDRETEIIRKNANESLIKDFLPVIDSMDAAIQAEKDNNLIRIRDQMLSILSKYGLQPIKAEGEKFDPYLHEAIGMTQDGEDGKIKYEVQRGYTLNNSVLRTSKVIVVKR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFH5_YEAS7
Sequence: MKFDNDSEKQVFDKLKKAIPGIIKEKCAGYDELYGYKLNPEGLTQEEVDKYYDEKIADRLTYKLCKAYQFEYSTIVQNLIDILNWRREFNPLSCAYKEVHNTELQNVGILTFDANGDANKKAVTWNLYGQLVKKKELFQNVDKFVRYRIGLMEKGLSLLDFTSSDNNYMTQVHDYKGVSVWRMDSDIKNCSKTVIGIFQKYYPELLYAKYFVNVPTVFGWVYDLIKKFVDETTRKKFVVLTDGSKLGQYLKDCPYEGYGGKDKKNNLTKQNVTNVHPTEYGLYILQKQIIEDVE
What is the function of this protein?
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity.  Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane (By similarity).  Heme-binding protein that may play a role in organic oxidant-induced stress responses (PubMed:32780017).
What are the official names of this protein?
Phosphatidylinositol transfer protein SFH5, PITP SFH5, SEC14 homolog 5.
What is the protein family that this protein belongs to?
Belongs to the SFH5 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: MAP6_XENTR
Sequence: MAWPCVTRACCIARFGNLQDKGDIAVPLMYSKYSEVTDGAQPPPPRPGSAAIETQPSLSDPYSGSLGRFSKKPESARGSVMRQDYQAWKANPEPSCKPRIEYQPSEAPLERETQYKKDFRSWPIPRQGDHPWIPKLSPSPTMPVIASDDKRKKDFVAPKAPPAEIKLINAEQPESAKGRGPTAFIAAPEILISVVQETNEIQKRESFMPKLPAKEPRATRDTGSPHPAQARGERGAGTSYRNEFRPWTDVKPVKPIKAKSQYQPPEEKVVHETSYKATFKGESNQPAAGDNKLMERRRIRSLYSEPSKESSKVEKPSVQTSKPKKTSTSHKPVKKAKEKIMASGRASKKKGAESSSTTKPEEKEKSKEINNKLAEAKE
What is the function of this protein?
Involved in microtubule stabilization in many cell types, including neuronal cells.  Specifically has microtubule cold stabilizing activity.  Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (By similarity).
What are the official names of this protein?
Microtubule-associated protein 6 homolog, MAP-6 homolog, Stable tubule-only polypeptide homolog, STOP.
What is the protein family that this protein belongs to?
Belongs to the STOP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MURC_SHEPC
Sequence: MTKTERYIQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNTVTDRLCLLGAKIQIGHAADNVQQVDVVVVSTAINAENPEIIAAKELRIPIVRRAEMLAELMRYRHGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSAGTNARLGTSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDPVVREIMPRIGRHLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKEDLDLLLNLPGQHNVLNALAAIAVATEDEIDDSALIQALAEFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIKAARAGWPEKRLVMAYQPHRYTRTRDLYEDFIEVLSQVDCLLLLDVYSAGEAPITGADGRALCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRQLAVTELGFAKVEIAQVPA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_METPP
Sequence: MPRRREVPKREILPDPKFGNVDLSKFMNVIMESGKKAVAERIIYGALETVEKKANRDPLEVFITALNNVKPMVEVKSRRVGGANYQVPVEVRPVRRMALAMRWLKESARKRSEKSMAQRLANELLEASEGRGGAMKKRDEVHRMAEANKAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RL17_STRCO
Sequence: MPKPSKGARLGGSAAHEKLLLANLAKSLFEHGRITTTEAKARKLRPYAERLVTKAKKGDLHNRRQVLQVITDKSIVHTLFTEIGPRYENRPGGYTRITKIGNRRGDNAPMAVIELVEALTVAQQATGEAEAATKRAAKDAEGSAEVSEAKVDTTKADDEAAAEESKDA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RF3_PHOLL
Sequence: MSNSPFQQEVAKRRTFAIISHPDAGKTTITEKVLLFGQAIQKAGTVKGRGSNQHAKSDWMEMEKQRGISITTSVMQFPYQDCLVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEERTRKLMEVTRLRDTPILTFMNKLDRDIRDPMELMDEVENELNIACCPITWPIGCGKSFKGVYHLYLDETYLYQTGKGHTIQEVRAIKGLNNPELDAAIGEDLAEQLRQELELVQGASHEFDHQAFLQGELTPVFFGTALGNFGVNHMLDGLVKWAPAPMPRQTDVREVSAQEDKFTGFIFKIQANMDPKHRDRVAFLRVVSGQYEKGMKLHQVRIKKDVVIADALTFMAGDRSHVDHAYPGDIIGLHNHGTIQIGDTFTQGEDLKFTGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLANNDLIVGAVGILQFDVVVARLKSEYNVEALYEPVNVSTARWVECHDAKKLEEFKRKSEQNLALDGGDNLTYIAPTMVNLNLTRERYPDINFRKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATNL_ARTSZ
Sequence: MSKIALITGSTRTPRVGTDVAAWVLDVIKSRPEDKLQVEPLSIADFNLPIYDEPVMPAMVPAMKQFTKEHSKKWSEAIQSFQGYVFVIPEYNGSMSGATKNAVDYLYNEWPGKPVAIVSYGTQGGERANKHLSESLELVMKMKVAPTKVTLAFAPGTDVFAAINEGVLGEDTRKAWTEAGHKEKILKAFGEVKEILEQ
What is the function of this protein?
NAD(P)H-dependent FMN reductase; part of the gene cluster that mediates the biosynthesis of the meroterpenoids arthripenoids (PubMed:29797385).  The pathway begins with the HR-PKS atnH that catalyzes two chain-extension steps to form a reduced triketide, which then primes the SAT domain in the NR-PKS atnG to initiate three more cycles of extension to give a linear hexaketide corresponding to the polyketide part of arthripenoids (PubMed:29797385).  The FAD-dependent monooxygenase atnJ then performs an oxidative decarboxylation at C11 of the atnH/atnG product, via an electrophilic aromatic hydroxylation with concomitant ipso-decarboxylation (PubMed:29797385).  The membrane-bound polyprenyl transferase atnF then introduces a farnesyl group before the FAD-dependent monooxygenase atnK functions as the first epoxidase on terminal C12'-C13' olefin, followed by a second epoxidation on C7'-C8' catalyzed by atnA (PubMed:29797385).  The terpene cyclase/mutase atnI then initiates the sequential tricyclic ring formation through protonation of the terminal epoxide and catalyzes the regioselective and stereoselective 6/6/6-tricyclic ring formation (PubMed:29797385).  The cytochrome P450 monooxygenase atnM is responsible for hydroxylating both C1' and C10' (Probable).  The next steps may involve ketoreduction and acetyl transfer by the ketoreductase atnB and the acetyltransferase atnC, and lead to the production of arthripenoid B, the final biosynthetic product of the atn cluster (PubMed:29797385).  The hydroquinone moiety in arthripenoid B is prone to undergo spontaneous oxidation to afford a benzoquinone compound, a key intermediate for generating structure diversity (Probable).  For instance, addition of a cysteine followed by ring contraction gives arthripenoid A, tautomerization gives the main product arthripenoid C, addition of a molecular of water or amine affords arthripenoid D or E, respectively, and loss of one water forms arthripenoid F (Probable).
What are the official names of this protein?
NAD(P)H-dependent FMN reductase atnL, FMN reductase atnL, Arthripenoid biosynthesis cluster protein L.
Protein: SYK_PHYAS
Sequence: MNKKMTEQEGIRHQKIEELKKLKTEPFGKNFTCSHTIENIILNYQNIDQEWFEENKVNVKIAGRIILKRGQGKAGFLHLQDFNFKIQVYLRSDLLGDAFLLYQNCDLGDIVGIKGFLFKTKTKELTIKALDFIHLTKSLKPLPDKFHGLQNREEMRKKRYLDLMVNEKSRQVFLTRSLIIKSIRNFFDNEGFLEVETPILQPSLGGASAKPFITSHNALNSDFYLRIATELPLKKLIVGGMPKVYEIGRIFRNEGMDATHNPEFSTIEAYQAYSDIQGMMELTQKCLQYICQTVLKSLEINYQNKKISFQTFQKISMTDAIKKETGIDFQKKLSQETCLQLAKQHDINVMSHFSQGHIIEVFFEKYVEHKLIQPTFIYGHPLEISPLAKKNLNNPRFTDRFELFIAGKEFVNAFSELNDPIEQEKRFLNQLKQKELGDDEACEMDYDFLDALSYGMPPTGGLGMGIDRIVMLLTDTPNIRDVILFPHFKNKNIIKKK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA2_NOSS1
Sequence: MALFGFGKKLALPTPEKALPGRAQIMPVPANHYVNKNPLKPPFPDGFEKALFGLGCFWGAERKFWQQQGVYSTAVGYAAGFTPNPTYDEVCTGLTGHNEVVLVVFDPKVISYTQLLKVFWESHNPTQGMRQGNDVGTQYRSGIYVYSEAQKQLAEASRDAYQQALSSAGYEKITTEILDAPEFYYAEAYHQQYLAKNPNGYCGLGGTNVACPVGVFESSANG
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA 2, Protein-methionine-S-oxide reductase 2, Peptide-methionine (S)-S-oxide reductase 2, Peptide Met(O) reductase 2.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: CAIA_ECOBW
Sequence: MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDSLLIPEEHGGLDAGFVTLAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFRGTGKQMWNSAITEPGAGSDVGSLKTTYTRRNGKIYLNGSKCFITSSAYTPYIVVMARDGASPDKPVYTEWFVDMSKPGIKVTKLEKLGLRMDSCCEITFDDVELDEKDMFGREGNGFNRVKEEFDHERFLVALTNYGTAMCAFEDAARYANQRVQFGEAIGRFQLIQEKFAHMAIKLNSMKNMLYEAAWKADNGTITSGDAAMCKYFCANAAFEVVDSAMQVLGGVGIAGNHRISRFWRDLRVDRVSGGSDEMQILTLGRAVLKQYR
What is the function of this protein?
Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
What are the official names of this protein?
Crotonobetainyl-CoA reductase, Crotonobetainyl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMO_RABIT
Sequence: MVKASGIPIALGVWGLCWSLATVNSVPLTSAHGNVTEGESGTKPEADVIEQCSDGWSFDATTLDDNGTMLFFKDEFVWKSHRGIRELISERWKNFIGPVDAAFRHGHTSVYLIKGDKVWVYTSEKNEKVYPKSLQDEFPGIPFPLDAAVECHRGECQDEGILFFQGNRKWFWDLTTGTKKERSWPAVGNCTSALRWLGRYYCFQGNQFLRFNPVSGEVPPGYPLDVRDYFLSCPGRGHRSSHRNSTQHGHESTRCDPDLVLSAMVSDNHGATYVFSGSHYWRLDTNRDGWHSWPIAHQWPQGPSTVDAAFSWEDKLYLIQDTKVYVFLTKGGYTLVNGYPKRLEKELGSPPVISLEAVDAAFVCPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKPLGPNSCSTSGPNLYLIHGPNLYCYRHVDKLNAAKNLPQPQRVSRLLGCTH
What is the function of this protein?
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
What are the official names of this protein?
Hemopexin.
What is the protein family that this protein belongs to?
Belongs to the hemopexin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GA45G_RAT
Sequence: MTLEEVRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVYESAKVLNVDPDNVTFCVLAADEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGADDEGGAPGDLHCILISNPNEDTWKDPALEKLSLFCEESRSFNDWVPSITLPE
What is the function of this protein?
Involved in the regulation of growth and apoptosis.  Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
What are the official names of this protein?
Growth arrest and DNA damage-inducible protein GADD45 gamma.
What is the protein family that this protein belongs to?
Belongs to the GADD45 family.
Protein: XGPT_RHILO
Sequence: MSLPEKAFPVSWDQFHRDARALSWRLSGANKGQWKAIVCITRGGLVPAAIIARELGIRVIETVCVASYHDYTSQGQLQVLKEITPALLADDGAGVLIIDDLTDTGKTAGIVRAMMPKAHFATVYAKPKGRPLVDTFVTEVSQDTWIYFPWDMGFTYQKPIADDHAG
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYT_GEOSM
Sequence: MNEINVTLPDGSQRPLPAGASIFDLAASIGAGLAKAAIAGKIDGNLVDLNTPLADGARVEIVTEKSPEALEIIRHSTSHLMAQAVKALFPQAKVTIGPAIETGFYYDFDVDHPFTPEDLEKIEEKMRELAKADLKIERRELTSADAIALFKGMGEDYKVELIEDLGADKVSLYSQGDFVDLCRGPHLPKTSYIKAFKLTSIAGAYWRGDEKRAMLQRVYGTAFGDKKELEAYLARIEEAKKRDHRKLGRELDLFSFNDEVGAGLVIWHPKGAMLRTILEDFERKEHLKRGYDIVLGPQILKTELWQRSGHYENYRENMYFTTVDEQSYGVKPMNCLAHMMIYRSQLRSYRDLPLRYFELGTVHRHERAGVLHGLLRVRGFTQDDAHILCTPDQLDAEIKGVIQFVTEVMGIFGFEFEMELSTRPEKSIGSDDAWELATSALLNALKDSGRPYEINEGDGAFYGPKIDIKLRDALDRRWQCATIQCDFTLPERFDLTYVDADGEKKRPVMVHRVILGAIERFIGVLIEHFAGNFPTWLAPVQATIVTVTDNQIPYAQAAFDKLRAAGIRVQKDFRNEKLGFKIREAQLQKIPYMLVVGDKEVESGMLAPRFRDGKNLESMTPEQFITFIENEVKSYK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN1_AJECH
Sequence: MGIKHLYQIIQENAPDAVKAGEIKNHFGRKVAIDASMSIYSFLIAVRSDGQQLTSETGETTSHLMGMFYRTLRIVDNGIKPVYVFDGAPPKLKSGELAKRFMRKSEAAEAHEEAKEVGTAEEVEKFSRRTVRVTREHNEECKKLLKLMGVPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFDSPILLRHLTFSEQRKEPILEIHLDRVLEGLDMDRKQFVDLCILLGCDYLDPIPKVGPNTALKLIRDHGSLEQVVEAIKSDPKKKYTIPEDWPYKEARELFFDPDVRNADHPDCDFKWEAPDVEGLVKFLVEEKAFSEDRVRNAAARLQKNLKTAQQSRLEGFFKPIAKTEQEKAVLKRKHEEKLELQKKKKKEDSKAKKEAKSKPRGTT
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: MUTS_PROMH
Sequence: MTDSQNFESHTPMMQQYLKLKAEHPEILLFYRMGDFYELFFDDAKKASRLLDISLTKRGQSAGQPIPMAGVPHHAVENYLAKLVQLGESVAICEQIGDPATSKGPVERKVIRIVTPGTVTDEALLEERQDNLLAAIWQDKNGAFGYATLDITSGRFRVTEMPDSESMAAELQRTHPAELLYPETFESMALIERQQGLRRRPIWEFECETAKQQLNLQFGTRDLTGFGVENARLALCAAGCLLQYVKDTQRTGLPHIRSITMERPQDTIILDAATRRNLELTQNLAGGCDNTLASVLDLCVTPMGSRMLKRWIHTPLRQREQLIKRQDAISALQPLYFELQPFLRQVGDLERVLARLALRSARPRDLSRMRHAFQQYQDIHQVLDQADMPYIKELQQRISQFDELRELLENAIVETPPVLVRDGGVIASGYNAELDEWRALADGASDYLEKLEVREREKWGIDTLKVGFNGVHGYYIQVSRGQSNLVPMHYVRRQTLKNAERYIIPELKEYEDKVLTSKGKALAIEKMLYEELFEKLLPHLTALQTSAEALAETDVLANLAERAESLNYTRPELTEKTGIQITGGRHPVVEQVLSEPFISNPLQLAPQRRLLIITGPNMGGKSTYMRQAALITLLAYIGSFVPAEKAVIGPIDRIFTRVGASDDLASGRSTFMVEMTETANILHNATENSLVLMDEIGRGTSTYDGLSLAWACAENLANRIKAMTLFATHYFELTTLPEKLEGTANIHLDAVEHGETIAFMHSVQEGAASKSYGLAVAALAGVPKEVIRRAKQKLKELETLSGHSGASHVETSQLMLLADIEPSEVELALNKIDPDSLTPKQALELLYHLKELNK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: ZN781_HUMAN
Sequence: MQRNAMYLKNVAETACNFQLTQYQISHANQKPYECQICGKPFRKRAHLTQHNRIHTGGKPYECKECGKVFICCSTLIQHKRTHTSEKPYECLECRKTFRRSAHLIRHQRIHTGEKPYKCKQCWKAFASVSDLIDIGKFTLMRDFTNVQNVGRHLTIAQLLFSIREFTLVRSPLNVRNVAKHSIIAQHLLNTRELILMRNLMNVRNVKRLLGKVHILLNIKEFILVRNHMSVSNVGRLSLVFLILIDIREFTLVKNPMNVKNVVELLTIVQLLFNTREFTLVRRLMNISSVGRFLSPVQHLFNIREHILMKNLMNVSNARRPSSIMHILFDIKEFILVRNLINVSNVGRPLLLFLI
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 781.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DPS_YERPG
Sequence: MSTAKLVKTKPSELLYTRNDVEEHVKVATIKRLNQMVIQFIDLSLITKQAHWNMRGANFVAVHEMLDGFRTALTDHLDTFAERAVQLGGVALGTAQVINDKTPLKSYPTNIHSVQEHLKALAERYAIVANDIRKAITEVEDENSADMFTAASRDLDKFLWFIESNIE
What is the function of this protein?
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages.  It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
What are the official names of this protein?
DNA protection during starvation protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm.