PharMolix/UniProtQA huggingface dataset:
Protein: HIS6_VIBC3
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVARVAEVIDIPFCVAGGIKSAQDAARILEFGADKVSINSPALANPQLITDLADRFGVQCIVVGIDSYFDKETGQYQVYQFTGDESRTRATQWQTCDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLNLVRSVCRVPLIASGGAGAMEHFAQAFTQANVDGALAASVFHKQIINIGELKQYLKQQGIEVRR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_ACIET
Sequence: MQALYDVPAPAKLNLFLHVTGRRPDGYHLLQSVFMLIDWCDVLHFEVRGNGTVTREDLTSALPADDLVVRAARALQKATGCPQGVHIGVSKHIPAQAGLGGGSSDAASTLLALNRLWKLKLSRQQLHSIALTLGADVPFFLCGASAWVEGIGDIIRRLELEHQLPPAAFAVVKPEAGLDTRMIFSHPSLKRDSSCATISGFAATHYQFGSNDLQPVAQALCPEITQAINWLESKGLQGRMTGSGSAVFAQITHAVDLHDAPAAWHVKVCENLKSHPLADWVFG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: METK_CLOBM
Sequence: MRKLFTSESVTEGHPDKICDQISDAVLDAILDKDPNGRVACETAVTTGMVMVMGEISTKCYVDIPKLVRETIRGIGYDRAKYGFDCETCSVITSIDEQSVDIAMGVDEALESKKGEMDKLDAVGAGDQGMMFGFATNETKEYMPMPIEMAHKLSRRLSEVRKNGTLPYLRPDGKTQVTVEYENGKPVRIDAIVISTQHGPEVYLEQIEKDIKEHVIKVIVPSELLDENTKYFINPTGRFVVGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGVADKLEIQLAYAIGVAKPVSISVDTFGTGKITDEEIVSIVNKVFDLRPGAIIRDLDLRRPIYKQVAAYGHFGRTDIDVPWERLDKVEEIKKHI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_METTH
Sequence: MITTVVGSYPTEPRGPETLGERLLNFFGSYDRYRPAIEAAVRDQFRAGVDIISDGQVRGDMVGHFAAAIGGMKIEDGTSIIYSRITPPAGSIGAADLRYAYRILRGLTDDESRGVKGIITGPSTMIYASRIEGFYDPQKRDRAVMDMAGVLKIEAKHLQDAGAAMIQIDEPFLSTGIVDMKTAGRAIDHIAAGLDIEVSLHVCGDIRNVLSDLLRFKVDVLDLEFAGRPSNLEVLEEKWRGDKGVGFGCVDTTTERVESMEEIRNLIKRGADIVGEENLYIDPDCGMRKLPRKAAFSKLRNMVMAAGN
What is the function of this protein?
Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation.  Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate.
What are the official names of this protein?
Methionine synthase, Homocysteine methyltransferase, Methylcobalamin:homocysteine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the archaeal MetE family.
Protein: XYLA_ACTPJ
Sequence: MSNYFDKIEKVKYEGADSTNPFAFKHYNPNEVILGKTMAEHLRLAVCYWHTFCWTGNDMFGVGSLDRSWQKTGDLLEGAKQKAEIAFEFFQKLGIPYYCFHDVDIAPEGNSYKEYVHNFHTMVDILEKKQAETGVKLLWGTANCFTNPRYMSGASTNPNPEVFSWAASQVFNAMNATKRLGGENYVLWGGREGYETLLNTDLKREREQIGRFMQMVVEHKHKIGFNGTLLIEPKPQEPTKHQYDYDVATVYGFLKQFGLEKEIKVNIEANHATLAGHTFQHEIATAAALDIFGSIDANRGDPQLGWDTDQFPNSVEENTLVMYEILKAGGFTTGGFNFDAKIRRQSTDPYDLFHGHIGAIDVLALSLKRAAKMIEDKTLQGIVDQRYAGWNGDLGQQILAGKASLEDLAKIVESKALDPKPVSGQQEYLENLVNNYIYR
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREF_GLOC7
Sequence: MNHSLLAPKLALMQLSDSFFPSGSFTLSHGLEALAQGEQIHSIKDLEIFLQILLHNKLGTTDLVALIHAYRGSKREDLDAVREADHQLFAQTLIEKNREMGRKSGRALLMVARETWQDTQLETLEKETAKGTINGLHPIIFAVVGRVAGLSETDTGLAFLHSFITGLLGAAIRLNIIGHLQAQKILLKLAPDLETTYQKATEINLNEMFSCTPLIDIAQMNHQNLDYRLFAN
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_RENSM
Sequence: MSVAIRVIPCLDVDAGRVVKGVNFADLRDAGDPVELARRYDGAGADELTFLDVTATSGNRETTFEMVARAAEEVFIPLTVGGGVREVADVDRLLRAGADKASINSAAVARPEVIDEITRHFGSQVLVLSLDARRVADGSTPSGFEVTTHGGRRGTGIDAVLWAREAADRGVGEILLNSIDADGTKAGFDLEMIRAVRAAVRVPLIASGGAGKPEDFPPAVQAGADAVLAASIFHFGPVDAIAQVKAAIRAAGFPVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_SALEP
Sequence: MKTLGEFIVEKQHEFSQATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDSSTSRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPQGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPESLHQRRSFFVGNRHMVDDVERFIREYPDA
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_KOSOT
Sequence: MPIDFRMTKKGLILLIESYSSIESLKQEIMAKFNEARDFFSEGDEISLMLTQETSKPDDIVNIVSLLGNLGVRVKDILVGSLEKKNVKIGQKYDLVREKVTEVRGAQVIKRNLRSGQIVVHNYDIIVFGNVHPGAEIIAGGSIVIFGTARGILRAGYSVGDEAVIAALDLKPSLIQISGLISQDYNVYETPAVAHIRTGRIVVEKIESAKFEVKGGKI
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: Y7SR_METFE
Sequence: MRIGFIGFGEVSSTLSQFFKDKVEVQTCVKGRSEKTKKIAKKLGVKIYKDYKDLVKNSDIVISAVTPFSALDVAKKYGKYVKGIYVDVNNVSPLTKHKILKYIDEEKFVDCAIIGRIKRKFKMICSGKNANKLKILEKFGVPIEVIGSKVGEASTLKMLRSLYTKSLAAILLEVFSVANKLGLIDELLEILEETEGKKFVDLCKSRVVGSFIHSRRRYEEICEIEKFILSHNLKPIMIKCTKNMFKHIEEC
What are the official names of this protein?
Uncharacterized 28.5 kDa protein in 7S RNA 5'region, ORF260.
Protein: PRO1_ARMGA
Sequence: MSQRIFLPDTLANWQWPRHLNPHYAEVKKASAAWAKSFRAFQTKAQEAFDRCDFNLLASFAYPLADEARLRSGCDLMNLFFVIDEYSDVATEEEVRAQKDIVMDAIRNTEKPRPAGEWIGGEVSRQFWDLAKKTASTQAQKRFIDTFDEYLESVVQQAADRNNSHVRGIESYLEVRRNTIGAKPSFALLEFDMQLPDEVINHPVIKELENSCIDMLCLGNDVVSYNLEQARDDDGHNIVTIAMNELRTDVAGAMIWVDEYHKQLESRFMENFKKVPRWGGPIDLQVARYCDGLGNWVRANDQWSFESERYFGKKGPEIIQRRWITLMPKMVSEELGPQIVDGSHL
What is the function of this protein?
Delta(6)-protoilludene synthase, part of the gene cluster that mediates the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols (PubMed:21148562).  The first step in melleolides biosynthesis is performed by the delta(6)-protoilludene synthase PRO1 which catalyzes the cyclization of farnesyl diphosphate to protoilludene (PubMed:21148562).  The orsellinic acid synthase armB produces OA by condensing acetyl-CoA with 3 malonyl-CoA units in a three-round chain elongation reaction folowed by a C2-C7 ring closure (By similarity).  ArmB further catalyzes the trans-esterification of OA to the various sesquiterpene alcohols resulting from the hydroxylation of protoilludene (By similarity).  The melleolides cluster also includes 5 cytochrome P450 monooxygenases, 4 NAD(+)-dependent oxidoreductases, one flavin-dependent oxidoreductase, and one O-methyltransferase (By similarity).  The cytochrome P450 monooxygenases may be involved in protoilludene hydroxylation to elaborate melleolides with multiple alcohol groups, such as melleolide D, which carries alcohol functionalities at C-4, C-5, C-10, and C-13 (By similarity).  The role of the NAD(+)-dependent enzymes remains unknown (By similarity).  Numerous melleolides, including arnamial, show 5'-O-methylation of the aromatic moiety which may be catalyzed by the methyltransferase encoded in the cluster (By similarity).  The flavin-dependent oxidoreductase might represent the dehydrogenase yielding the aldehyde in position 1 of arnamial and other melleolides (By similarity).  Finally, several halogenases, localized outside of the cluster, are able to catalyze the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product (By similarity).
What are the official names of this protein?
Delta(6)-protoilludene synthase, Melleolides biosynthesis cluster protein PRO1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: MNME_GLUDA
Sequence: MPTEQMPIFALATGAGRAAIAVMRLTGAGCGDMLQRLCGPLPPPRQASLRGLWRRDAAAAPVLLDRALVLWFPGPRSYTGEDSAELHLHAGPAVIAGVADALVALGARPAEPGEFTRRAFAHGRLDLIEAEGIADLIDAETEAQRRQALDQADGTLSRIYDGWAARLRTLLAHQEALIDFPDEDLPPGVEQALLDDLTALRSEMQAHLDDGGRGEKLRRGLVFTIVGAPNVGKSSLLNALAGRDAAIVSAIAGTTRDAIEIRVVLGDVPVTLIDTAGLRETQDEIEAEGVRRALFHVKHADCVIAMFDGETVPDDIPADAIRVRNKVDLAPVPAGADAIGISVRQGTGMDALRTALAERARALTASAAGPPLTRARHRAAIEETAGHLAAALDMHWPEMRGEEMRLAMRALGRLTGAVGVEDLLDTVFGQFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERC_PARD8
Sequence: MKKHNFYAGPSILSEYTIKNTAAAVENFAGMGLSLLEISHRSKEFVAVNDEARALIKELLDVPAGYEVVFMGGGASMQFCMVPYNLLNKKASYLDTGTWASNAIKEAKLFGEVDVVASSKDKNYTYIPKGYAIADDSDYFHFTSNNTIYGTEMRKDPDVKQRLVCDMSSDIFSRPIDISKYDIIYAGAQKNLAPAGVTLAIVRVDALGHVDRPIPTMLNYATHIKKDSMFNTPPVLPIYAALQTLKWYKEQGGIAAMEKKDLENAAILYDEIDRNKLFRGTVAEEDRSIMNVCFVMNDEYKELEDEFSKYATAAGMVGIKGHRSVGGFRASLYNAMPKSSVEALVACMKEFEKQH
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUO5_SOLTU
Sequence: ATEAQAAINEXPDRVKKDYFYGR
What is the function of this protein?
Transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 29 kDa subunit, Complex I-29kD, CI-29kD.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: CSPLQ_ORYSJ
Sequence: MKDVVGSPGTWSGMSLRVSQCVFAGASVVAMASAYGFSNYTAFCYLIASMGLQLLWSFGLACLDIYSLQTKRDLHNPVLVSLFVVGDWVTAILSFAAASASAGVTILFERDVHFCRMYPQLSCGRYELSVILAFITWSFIATSAVSMFWLLASL
What are the official names of this protein?
CASP-like protein 5B3, OsCASPL5B3.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YBHG_ESCF3
Sequence: MMKKPVVIGLAVVVLAAVVAGGYWWYQSRQDNGLTLYGNVDIRTVNLSFRVGGRVESLAVDEGDAIKAGQVLGELDHKPYEIALMQAKAGVSVAQAQYDLMLAGYRDEEIAQAAAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLRQYRSGNREQDIAQAKASLEQAQAQLAQAELNLQDSTLIAPSDGTLLTRAVEPGTVLNEGGTVFTVSLTRPVWVRAYVDERNLDQAQPGRKVLLYTDGRPDKPYHGQIGFVSPTAEFTPKTVETPDLRTDLVYRLRIVVTDADDALRQGMPVTVQFGDEAGHE
What are the official names of this protein?
UPF0194 membrane protein YbhG.
What is the protein family that this protein belongs to?
Belongs to the UPF0194 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: APT_FUSNN
Sequence: MDLKNYVASIENYPKEGIIFRDITPLMNDGEAYKYATEKIVEFAKDHHIDIVVGPEARGFIFGCPVSYALGVGFVPVRKPGKLPREVIEYAYDLEYGSNKLCLHKDSIKPGQKVLVVDDLLATGGTVEATIKLVEELGGVVAGLAFLIELVDLKGRERLDKYPMITLMQY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCR5_MANSP
Sequence: MDYQVSSPTYDIDYYTSEPCQKINVKQIAAHLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNIMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPYSQYQFWKNFRTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
What is the function of this protein?
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.  May play a role in the control of granulocytic lineage proliferation or differentiation.  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
What are the official names of this protein?
C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFG1P_ASPOR
Sequence: MPREDSRSQSPVSRPSGDRHYRDRSDPPKRKHNSDGASHQPYRKKVQLPKKEHQYPSVNELKKRIRDVKRLLNRVDLPADARIVQERALAGYENDLEEEEKRRERSKMIKKYHFVRFLDRKTASKDVKRLERREKEVSGSDLDSAAKEQKLAALAQKLRVARVNLNYTIYYPLAERYIALYADAKKKKEMVKDGNNDEDGDAGYTLVHANAADKPAMWHTVEKCMKDGTLELLRDGKLKNGESGAVTKEKSNVDKKKTSIRDSVQQKDTTKTSVKPQRREDKNAKDSRGFSSKNDSRHSRARQSSPDDNGDESDGGFFEM
What is the function of this protein?
Involved in rRNA processing.
What are the official names of this protein?
rRNA-processing protein efg1.
What is the protein family that this protein belongs to?
Belongs to the EFG1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CGR1_CANAL
Sequence: MSSSSNLQYEEIPKKYIDPLAPKDKGEGSRVNGKDWKIKKDAFRVKTLGVVSKTKKDSFKQRELKRLEEEQYKARLKELKDEKESAKNQRIADLKRRREIKAEKERYERMATKMHAKKVERMRKREKRNKLLKER
What is the function of this protein?
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
What are the official names of this protein?
rRNA-processing protein CGR1.
What is the protein family that this protein belongs to?
Belongs to the CGR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: T2BA_BACAM
Sequence: MEVEKEFITDEAKELLSKDKLIQQAYNEVKTSICSPIWPATSKTFTINNTEKNCNGVVPIKELCYTLLEDTYNWYREKPLDILKLEKKKGGPIDVYKEFIENSELKRVGMEFETGNISSAHRSMNKLLLGLKHGEIDLAIILMPIKQLAYYLTDRVTNFEELEPYFELTEGQPFIFIGFNAEAYNSNVPLIPKGSDGMSKRSIKKWKDKVENK
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GGATCC-3' and cleaves after G-1.
What are the official names of this protein?
Type II restriction enzyme BamHI, R.BamHI, Endonuclease BamHI, Type-2 restriction enzyme BamHI.
Protein: FUS_SENDA
Sequence: MATYIQRVQCISALLSVVLTTLVSCQIPRDRLSNIGVIVDEGKSLKIAGSHESRYIVLSLVPGVDLENGCGTAQVIQYKSLLNRLLIPLRDALDLQEALITVTNDTMTSADVPQSRFFGAVIGTIALGVATSAQITAGIALAEAREAKRDIALIKESMTKTHKSIELLQNAVGEQILALKTLQDFVNDEIKPAISELGCETAALRLGIKLTQHYSELLTAFGSNFGTIGEKSLTLQALSSLYSANITEIMTTIRTGQSNIYDVIYTEQIKGTVIDVDLERYMVTLSVKIPILSEVPGVLIHKASSISYNIDGEEWYVTVPSHILSRASFLGGANIADCVESRLTYICPRDPAQLIPDSQQKCILGDTTRCPVTKVVDNLIPKFAFVNGGVVANCIASTCTCGTGRRPISQDRSKGVVFLTHDNCGLIGVNGIELYANRKGHDATWGVQNLTVGPAIAIRPVDISLNLAAATDFLQDSRAELEKARKILSEVGRWYNSGATLITIIVVMIVVLVVIIVIVIVLYRLRRSMLMSNPAGRISRDTYTLEPKIRHMYTNGGFDAMTEKR
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) interacts with HN tetramer at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
What are the official names of this protein?
Fusion glycoprotein F0, Protein F.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: Y1424_HAEIN
Sequence: MHRLRQCNMKWGAEEEKKIELQAQGLQPDTLFSDVIKRYLNKITPTKRGEKHEFNRLNRFLRHPVTDKYISDVSRRDIEDWIAERLESVKSESVRRELSTIGHIFKIALERWGYIQKSPMVGIQLPEKGKPRTQRVTEENINAIVAISEYVDTLKTAKARTAAAILFAVETAMRAGKICSLSWGNVNFEKRTAFLPMTKNGTSRTVPLTKNAIAILERLKVEIGDAGLCFDIKSSVLDATFRKLKKLAEREYLHFHDTRREALTRLSKKVDVMTLAKISGHKDISILQNVYYAPDMAEVAELLD
What are the official names of this protein?
Putative integrase/recombinase HI_1414.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: RL22_RHOOB
Sequence: MSNTETANPTAKAVARHVRVTPMKARRVVDLVRGRSVEDALNILKFAPQAASEPVAKVIASAAANAENNLDLDPSTLVVATAFVDEGATLKRFQPRAQGRAFRIRKRTSHITVIVESLPKTGTSTRNRRKGSAQ
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: MRAY_BUCBP
Sequence: MIIRFILSFFTSLLLMLIFGPHLINWLNKYKIQQIIRNFGPKSHFNKKNTPTMGGILIIFSIIISTIIWTKLSNPYVWLTLTILIGYGIIGFIDDNMKIYYKNSKGLSSLHKFSLLSILACIIIFLIYYIINDHSTIKLIVPFSKNIIFNTKMICILISYFAIIGTSNAVNLTDGLDGLAIVPIIFVTTNLSIISFISGNVNLSYYFNTIYIPYSNELTIICAAIIGSSLGFLWFNTYPAQIFMGDVGSLSLGGTIGIISVLLRQEILLIIVGGLFVIETLSVIIQVLYYKITKKKLFKMTPIHHHYELNGCPETRLIIRFWIISFILMLLGLLMLKVHQ
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UL24_FHV1
Sequence: MMKREQRRSVGLRLRAGIRCHNRFYAVLKRDISSTSASGVYTDRLECLLGGSVSAESLKKAKGVYLACEVNLGRRRPDCVCTIQ
What are the official names of this protein?
Protein UL24 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL24 family.
Protein: Y1119_STAA3
Sequence: MISKINGKLFADMIIQGAQNLSNNADLVDSLNVYPVPDGDTGTNMNLTMTSGREEVENNLSKNIGELGKTFSKGLLMGARGNSGVILSQLFRGFCKNIESESEINSKLLAESFQAGVETAYKAVMKPVEGTILTVAKDAAQAAIEKANNTEDCIELMEYIIVKANESLENTPNLLAVLKEVGVVDSGGKGLLCVYEGFLKALKGEKVEAKVAKIDKDEFVHDEHDFHGVINTEDIIYGYCTEMMVRFGKNKKAFDEQEFRQDMSQFGDSLLVINDEEIVKVHVHTEYPGKVFNYGQQYGELIKLKVENMREQHREVIRKEQHTAKPKMETVETAIITISMGEGISEIFKSMGATHIISGGQTMNPSTEDIVKVIEQSKCKRAIILPNNKNILMASEQAASIVDAEAVVIPTKSIPQGISALFQYDVDATLEENKAQMADSVNNVKSGSLTYAVRDTKIDGVEIKKDAFMGLIEDKIVSSQSDQLTTVTELLNEMLAEDSEILTVIIGQDAEQAVTDNMINWIEEQYPDVEVEVHEGGQPIYQYFFSVE
What are the official names of this protein?
Uncharacterized protein SAUSA300_1119.
Protein: KAD_LISMC
Sequence: MKLVLMGLPGAGKGTQAEQIVEKYNIPHISTGDMFRAAMKNNTELGKKAKSFMDNGDLVPDEVTNGIVRERLAEDDAKNGFLLDGFPRTVEQAEELENILNDLGTELDAVINIEVDKDVLMKRLTGRWICRTCGKTYHEIYNPPKVPGKCDLDGGELYQRDDDKKETVEKRLNVNMKQTKPLLDFYSEKGKLHNINGEQDIKDVFVDVEKILASF
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZFX_MOUSE
Sequence: MDEDGLELQQQAPNSFFDATGAGATHMDGNQIVVEVQETVYVSDVVDSDITVHNYVPDDPDSVVIQDVIEDVVIEDVQCTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHCTVPDDVLASDITSASISMPEHVLTSESIHVSDVGHVEHVVHDSVVEAEIVTDPLAADVVSEEVLVADCASEAVIDANGIPVNQQDEEKNNCEDYLMISLDDAGKIEHDGSSGLTMDNETEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENEHGVELLDPNNSIRVPREKMVYMAVNDSQQEEEELNVAEIADEVYMEVIVGEEDAAAAAAAAVHEQQVEDNEMKTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYECQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALVHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQSELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP
What is the function of this protein?
Probable transcriptional activator.
What are the official names of this protein?
Zinc finger X-chromosomal protein.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
What are the subcellular locations of this protein?
Nucleus.