PharMolix/UniProtQA huggingface dataset:
Protein: LUXS_BACC0
Sequence: MPSVESFELDHTIVKAPYVRHCGVHNVGSDGIVNKFDIRFCQPNKQAMKPDVIHTLEHLLAFNLRKYIDRYPHFDIIDISPMGCQTGYYLVVSGTPTVREIIDLLELTLKDAVQITEIPAANETQCGQAKLHDLEGAKRLMNFWLSQDKDELEKVFG
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: RS12_AROAE
Sequence: MPTINQLVRKPRQLAVIKSKVPALDACPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVISYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGSLDLQGVKDRKQSRSKYGAKRPKKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SSPN_HALH5
Sequence: MAKMKHGSAQFRPDHLGTQPRKSDANKGKKMNTKGNENPQYIPPKG
What are the official names of this protein?
Small, acid-soluble spore protein N, SASP N.
What is the protein family that this protein belongs to?
Belongs to the SspN family.
Protein: ARPIN_HUMAN
Sequence: MSRIYHDGALRNKAVQSVRLPGAWDPAAHQGGNGVLLEGELIDVSRHSILDTHGRKERYYVLYIRPSHIHRRKFDAKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDGAEDEEWDD
What is the function of this protein?
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors.  Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex.  Involved in steering cell migration by controlling its directional persistence.
What are the official names of this protein?
Arpin, Arp2/3 inhibition protein.
What is the protein family that this protein belongs to?
Belongs to the Arpin family.
What are the subcellular locations of this protein?
Cell projection, lamellipodium. Note=Colocalized with the WAVE complex at lamelliupodium tip.
Protein: SUB3_TRITO
Sequence: MGCIKVISVFLAAIAAVDARAFFHNRGGSDVIPNSYIVVMKDGVTTEDFDSHISTVAATHNLNKAKRGSEAVGHKDSFNINGWRAYNGHFDEATIESILNDDKVNYVEHDRVVKLAALVTQPNAPTWGLGRVSHRAPGNRDFVYDSSAGQGITIYGVDTGIDIRHPEFAGRIRWGTNTVDNDNTDGNGHGTHTAGTFAGTTYGVAKKANIVAVKVLSAGGSGSTAGVIKGIDWCVTDVRSRNALGKAALNLSLGGSFSQANNDAVTRAQEAGIFVAVAAGNDNRDARNYSPASAPAVCTAASSTIDDQKSSFSNWGSIVDIYAPGSSILSAAPGGGTRTLSGTSMASPHVCGVGAAMLAQGVSVAQVCNRLKQIGNAVIRNPGTSTTNRLLYNGSGQ
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CNTE_STAAM
Sequence: MKGAMAWPFLRLYILTLMFFSANAILNVFIPLRGHDLGATNTVIGIVMGAYMLTAMVFRPWAGQIIARVGPIKVLRIILIINAIALIIYGFTGLEGYFVARVMQGVCTAFFSMSLQLGIIDALPEEHRSEGVSLYSLFSTIPNLIGPLVAVGIWNANNISLFAIVIIFIALTTTFFGYRVTFAEQEPDTSDKIEKMPFNAVTVFAQFFKNKELLNSGIIMIVASIVFGAVSTFVPLYTVSLGFANAGIFLTIQAIAVVAARFYLRKYIPSDGMWHPKYMVSVLSLLVIASFVVAFGPQVGAIIFYGSAILIGMTQAMVYPTLTSYLSFVLPKVGRNMLLGLFIACADLGISLGGALMGPISDLVGFKWMYLICGMLVIVIMIMSFLKKPTPRPASSL
What is the function of this protein?
Involved in the export of the metallophore staphylopine.
What are the official names of this protein?
Staphylopine export protein.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACLY_HUMAN
Sequence: MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM
What is the function of this protein?
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
What are the official names of this protein?
ATP-citrate synthase, ATP-citrate (pro-S-)-lyase, ACL, Citrate cleavage enzyme.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RL4_AQUAE
Sequence: MKIGDVEVRDDVFNVKVKKHVLWEVVKWQLAKRRQGTHSTKTRGEVAYSGRKILPQKGTGNARHGERGVNIFVGGGVAHGPKPRDYEYPLPKRVRKLGLKMALSDKARNNAIIFVDNIDLGKKPKTKKAIEFLKNLGVEKEKVLVVIPEKADVLYKSFRNLPNVRVLLPEGLNVYDVLWANKLVIQKDCLDRIYKKVEA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: DCOR_DICDI
Sequence: MTGTKRNGEEVVNENNNNNVAEETNKKAKVDESSTETTESTSCSLLSRCEKLDIVRKELDVKPWDQGKVTIQELITSLLDKTDRDAFFVADVGVIIKQWQKWVKNLPNVKPYYAVKCNPTVGVLRVLDALGTNYDCASRTEIESVLNLGVDPSRIIYANPCKQISALKFARAHNVKLMTFDNLSELEKIEKFFPEAELVLRIAPDDSKSVMRFGSKFGVHIDDCNDLLEMAKEMNLKVVGVSFHVGSGCQSGDSYADALIMVKSVFDMAKKLNMELTLVDVGGGFTGSDDEKFNAFTKVIREKTAELFSPNVKIIAEPGRYFAAQSHTLAVTVISKRSIKQEDNRQHPRRTSNNMRQYNYYLADGVYGSFNNTKFDYAKVEPLLLKPSTKQPTPCTLFGPTCDSIDVVLKDTQIPELKIGDWLYFQDMGAYTIASSSSFNGFCPPPVYYYNSIPEEELKNL
What is the function of this protein?
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.  Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
What are the official names of this protein?
Probable ornithine decarboxylase, ODC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Protein: VPB12_MYCTO
Sequence: MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE
What is the function of this protein?
Putative antitoxin component of a possible type II toxin-antitoxin (TA) system.  The cognate toxin is VapC12 (By similarity).
What are the official names of this protein?
Putative antitoxin VapB12.
Protein: RPOA2_PSYIN
Sequence: MQGSVIEFLKPNLVGIEQINATRAKVTLGPLERGFGHTLGNALRRILLSSMPGTAVTEVEIDGVQHEYSTKEGVQEDILEILLNLKGLAVKLEGKDNVLVSLTKSGAGPVTAGDITHGSDVEIVNPEHVICHLTGNAEISMRIKIESGRGYVPASSRIHTEEDERPIGRLLVDATFSPVERIAYSVESARVEQRTDLDKLVIDMETDGTLDPEEAIRRAATILAEQLDAFVDLRKVSEPVAKEEKPEFDPILLRPVDDLELTVRSANCLKAETIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASLSED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha 2, RNAP subunit alpha 2, RNA polymerase subunit alpha 2, Transcriptase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RARC_BPP22
Sequence: MKGMSKMPQFNLRWPREVLDLVRKVAEENGRSVNSEIYQRVMESFKKEGRIGA
What is the function of this protein?
This protein acts as a transcriptional repressor of its own gene arc and of gene ant.
What are the official names of this protein?
Transcriptional repressor arc.
What is the protein family that this protein belongs to?
Belongs to the p22 arc/mnt family.
Protein: GLGA_PROMA
Sequence: MRVLFAAAECAPMVKVGGMGDVVASLPSALAKLGHDVRLIIPGYSKLWGLLDISKDPIYTAQTMGAEFSVYETKHPTSNLPIYLVGHPVFDPERIYGGEDEDWRFTFFASATAEFAWNVWKPQVLHCHDWHTGMIPVWMHQDPEISTVFTIHNLKYQGPWRWKLERMTWCPWYMSGDHTMAAAMLFADRVNAVSPTYSREIRTSEYGESLEGLLNYISGKLRGILNGIDLDEWDPATDKALPANFSSGKMSTRKKNKEALQRQMGLEVNNDKYLLGMVGRLVDQKGVDLLLQVSRRLLAYTDSQIVVLGTGDQILESALWELAIDHPGRFAVFLTYDDYLSRLIYAGSDAFLMPSRFEPCGISQLLAMRYGSIPIVRNVGGLVDTVIPHDPINKSGTGFCFDRFEPIDFYTALVRSWEAFRHRRSWKELQKRAMTQMYSWERSAMEYETMYKEVSGYKEPSPDAIEVEKFSVGQDADPSLKNEKLSVGQDEDSSLKNERFI
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: YIDD_STRPD
Sequence: MMKKLLIVSVKAYQKYISPLSPPSCRYKPTCSAYMLTAIEKHGTKGILMGIARILRCHPFVAGGVDPVPEDFSLMRNKNTSKNAEKA
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: U71C1_ARATH
Sequence: MGKQEDAELVIIPFPFSGHILATIELAKRLISQDNPRIHTITILYWGLPFIPQADTIAFLRSLVKNEPRIRLVTLPEVQDPPPMELFVEFAESYILEYVKKMVPIIREALSTLLSSRDESGSVRVAGLVLDFFCVPMIDVGNEFNLPSYIFLTCSAGFLGMMKYLPERHREIKSEFNRSFNEELNLIPGYVNSVPTKVLPSGLFMKETYEPWVELAERFPEAKGILVNSYTALEPNGFKYFDRCPDNYPTIYPIGPILCSNDRPNLDSSERDRIITWLDDQPESSVVFLCFGSLKNLSATQINEIAQALEIVDCKFIWSFRTNPKEYASPYEALPHGFMDRVMDQGIVCGWAPQVEILAHKAVGGFVSHCGWNSILESLGFGVPIATWPMYAEQQLNAFTMVKELGLALEMRLDYVSEDGDIVKADEIAGTVRSLMDGVDVPKSKVKEIAEAGKEAVDGGSSFLAVKRFIGDLIDGVSISK
What is the function of this protein?
Possesses quercetin 7-O-glucosyltransferase and 3'-O-glucosyltransferase activities in vitro.  Also active in vitro on benzoates and benzoate derivatives.  Glucosylates other secondary metabolites in vitro like trans-resveratrol, curcumin, vanillin and etoposide.
What are the official names of this protein?
Flavonol 3-O-glucosyltransferase UGT71C1, Flavonol 7-O-beta-glucosyltransferase UGT71C1, UDP-glycosyltransferase 71C1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: AROC_LEPIN
Sequence: MPSSWGKIFKVSTFGESHGTSVGVVVEGVPAGIPIRLEEIQKDLNRRRPGQSNLTTPRDETDTVRVVSGVFEGKTIGSPIALIVDNQNTISKDYENLRTTFRPSHADYTYQMKYGFRAHVGGGRSSVRETIGRVAAAAIARMILKDDLGIETIAWVDSIGTVQSNIGDKYPKSREEVDQNEVRCPDVGSADQMRSLILKMKEAGDSVGGTIQCVSYNLPPGLGDPVYDKLDGDLAKAILSIPACKGFEVGSGFSGTLLTGSSHNDEFYVEEGTGRVRTRTNHSGGLQGGISNGEELVIRAAFKPTSTIFKKQNTINLKGEETILEAKGRHDPCVLPRAVPIIEAVVNLVLIDAYLYQRAINPQWFQKWARIPDYYKDLEL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PSBA_AETGR
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAVVEAPSTNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TRMD_FRATH
Sequence: MKFGIISIFPEMFKAINDFGVTARAIKDSKVSISCFNPRDYTTDRHATVDDTSFGGGAGMVMKYQPLSAAIEDAKNTLGCGTKVVYLSPQGSIFNHRKAQELLQNDSLILLCGRYEGVDERLIQDYVDEEISVGDFVLSGGELPAMLVMDSLIRLLPEVLGNKESVVEDSFYDGLLDYPHYTKPAVLPNGNAVPDVLLSGNHKEIAKWRRKQKLIRTYERRKDLIECLCLSAKDKQILDDYKIDKVSTKGEE
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_MYOAU
Sequence: MTNIRKSXPXXKIIXXSFIDLPAPSNISSWWNFGSLLGICLALQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWILRYLHANGASMFFICLYLHMGRGLYYGSYMYTETWNVGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFLLPFIIAAMVMVHLLFLHETGSNNPTGIPSNADMIPFHPYYTIKDILGLLLMITTLLMLVLFAPDMLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILIIIPLLHTSKQRSMTFRPLSQCLFWLLAADLLTLTWIGGQPVEHPYVIIGQLASILYFSIIIILMPLTSLMENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: WAKLG_ARATH
Sequence: MGVDVKRFLVVMLLLRICEYAAASTFPLALRNCSDHCGNVSVPYPFGIGKGCYKNKWFEIVCKSSSDQQPILLLPRIRRAVTSFNLGDPFSISVYNKFYIQSPLKHSGCPNRDGYSSSSLNLKGSPFFISENNKFTAVGCNNKAFMNVTGLQIVGCETTCGNEIRSYKGANTSCVGYKCCQMTIPPLLQLQVFDATVEKLEPNKQGCQVAFLTQFTLSGSLFTPPELMEYSEYTTIELEWRLDLSYMTSKRVLCKGNTFFEDSYQCSCHNGYEGNPYIPGGCQDIDECRDPHLNKCGKRKCVNVLGSYRCEKTWPAILSGTLSSGLLLLIFGMWLLCKANRKRKVAKQKRKFFQRNGGLLLQQQTSFLHGSVNRTKVFSSNDLENATDRFNASRILGQGGQGTVYKGMLEDGMIVAVKKSKALKEENLEEFINEIILLSQINHRNVVKILGCCLETEVPILVYEFIPNRNLFDHLHNPSEDFPMSWEVRLCIACEVADALSYLHSAVSIPIYHRDVKSTNILLDEKHRAKVSDFGISRSVAIDDTHLTTIVQGTIGYVDPEYLQSNHFTGKSDVYSFGVLLIELLTGEKPVSLLRRQEVRMLGAYFLEAMRNDRLHEILDARIKEECDREEVLAVAKLARRCLSLNSEHRPTMRDVFIELDRMQSKRKGTQSQAQNGEEHAHIQIAMPESMSLSYSSPNIVVENSSFSLDTKPLMPHKTQ
What is the function of this protein?
Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component.
What are the official names of this protein?
Wall-associated receptor kinase-like 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MUTS2_STRSV
Sequence: MNTKILETLEFSKIKELFAPYLLTEQGQLELGLLLPTSKKETVVSAFLEMTDMQQIFVQHPHFSLAATQDITALTKRLELESDLNIEEFLALKRVLAVTQELKSFYEDLENVHLEKLDRLFDNLAVFPKLQGSLQAVNDGGFIESFASESLSRIRRKIQENENQVREILQEILKNKGEMLADQVVASRNGRNVLPVKNTYRNRISGVVHDISASGNTVYIEPRAVVNLNEEIASSRADERYEIQRILQELSDLFRPHAAEIANNAWIIGHLDLVRAKVRFMQETGAVVPDLSEEQDIQLLSVRHPLIENAVANDLHFGLDLTEIVITGPNTGGKTIMLKTLGLAQIMAQSGLPILADKGSRVGIFSQIFADIGDEQSIEQSLSTFSSHMTNIVSILEQVDSESLVLLDELGAGTDPQEGAALAIAILEDLRLRQIKTMATTHYPELKAYGIETDWVENASMEFDTDSLRPTYRFMQGVPGRSNAFEIAQRLGLSEVIVGHAQEQTDTDSDVNRIIERLEEQTLESRKRLDNIREVEQENLKFNRALKKLYNEFNREKETELNKARLEAQEIVDLALSESESILKNLHDKSSLKPHEIIEAKAQLKKLAPETVDLSKNKVLKQAKKNRAPKVGDDILVTSYGQRGTLVKQLKDGRWEAQVGLIKMTLEEQEFNLLKAEKEQQPKRKQVNVVKRANTAGPKARLDLRGKRYEEAMEELDAFIDQALLNNMAQVDIIHGIGTGVIREGVTKYLRRNKHVKSFGYAPQNAGGSGATIVIFK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: RLMH_STRM5
Sequence: MKARLIATGERAPSWVAQGFAEYQKRLSHWLPFELVEIEPGLRGKGRDPRRATEDEGKRVIAALPKNAYVVALDVPGRQLSSEQLAQRLEHWRGQGRDLAFLIGGPEGHSPEVSALADEKWSIGPLTLPHMLVRLVVAEQLYRAAAMLANHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POLG_CACV4
Sequence: MASAIALSSSTAQNKITLKSVASRLQQTDDPDIRVWSQSVGFHLQFSNWKCANAFCRFVTDAYNLTPYKECARSITRQLTSLSNYLSAQTGVSVSGTQFLLSPSDVEVPVAKTGESVSDIMVPSYSVNGTSMEFDSMAQLAQALTTGFTFSVNDAQIGNAPAQTGESVSGTGFIAEACPSCALYDKCPNCTSELINDDGSSQSPGDIPHWTHHKIASGIVNILSSDMSSMEDDDFANIAAHVKKALGTNSHPANNDMSKDQLNWLLNIAEASLIRKADRTALPMNAARIAARRGWREKLFNEPADKLYTLLRKSKDSFQKSAIWGILFEKASNAKHYTEIVFQDIVKLIKEECNPSNNFYFKVMAQSFLDHFRMLVIDNPDPVANLPKFILKLKPLNLKMIIENHENTAEGWIVTLTAVAELYGWLEFAVDLVPKIVSELYDLLTSATQKCFSMVRELLTNLNILKAESFDFTNPFWYALAALLSYFVTGFLPNNAKCSAIKQTLNGATTLVAGITAIQKLAAMFSAWSNESVVDDLSTKVIGLTEADNPTVTQDIDAVTNLQIMAEQLKDQIKLKTLDPTFQPYLPVLRNLMSTTDSVISHCAKRKALATQRTAPVCIILTGPAGCGKTTLAYAIANRLSAQKPSVLNLNIDHHDAYTGNEVCIIDEFDSNPDSKFVEFVVEMVNTNPMLLNCDLIENKGKTFSSKYVIMTSNNETPVKPNSTRAPPFYRRVRIIDVTNPGVMSFKYENPGQEVPSYLFSNDFNHLSMSMRGFGAFSKTRVIDPEGRKTCGLEGPPGQRVDVDDIVRYMQRMYRENQMNFKSEAGNNRLKTPRFAFVTQRKHVDTVYKILAAAKTTYNGYYSLTKDSFDVNEGHNIGSSVFVVGDDKEIPHNCKIFRCNHLAMFRHPELAHIEGDNFRAALGVTMSDQDVTLMFYHIRGKHIQDEVRLDELPANHHIVTVHSVYDMAWALNRHLSLTGKWQALKAVYDLYMTPDILPAALRHWMDNTKFSSDHVVTQFIVPGGTIILETCNGARMWATSRRLIRAGGISNNNGPEGGFRFGSIAPRDIPWSEILREFLNLISLIWSRVKGATIVLTALLLYMKRYKPRSEAKGKTKGGRGAIRHGGKGIVLSDDEYDEWREFNMEKRMDMSVDEFLMLKHRAALGSDDTGAIQFRSWWTARQMRESTGLDHDDVTVIGKGGVRHEVHRTEIMKAPKQKKKSFAWGEDMYAEGDGKIVNHVNAIVPVTGLCGEHIGYAVHIGHGKCISLKHVLKTGSYVFNQKPIDVTFDGELAHFQIQQPPSSAAPVTFSSKPTRDPWGRSVSTEWKHDTYNTTAGKMYGSICWTATRTQPGDCGLPYVDRAGQVVGLHAGSGGDSAPGRKIVIPVTKFKLPSNTVLSNRFWKEEAPTISYKGLTVQETGVNKAVLKGTNYHVSPAHVDDYQDCTHQPANLGAQDERYPVSLTSIVINNLEPYKQPTQGPPTEVLNKAYNMLVQHYEPLIPKATTHLEMGDAFAALNVKTSCGPYITGRKKDHIDPETGKWDETLRNHINARWSLATQGVPIPHEYQLGLKDELRPKDKIAVGKRRLIWGCDVGVAVVAASAFKEVSSAIMAMSEFDFIQVGINMDGTAVETLYKRLYTPGTHRYCVDYSKWDSTQPPNVTRMSLELLRHFTDKSPVVDSAVATLSSPSIAVFGGVSFKTNGGLPSGMPLTSILNSLNHCLLVGSAIIQVLESKGVDVNWNIYDTIDLFTYGDDGVYIVPNFVHSVMPEVFSCLSSYGLKPTRTDKSSAPITEIPLSEPIEFLKRQFVRNQFGVRALLDRSSLIRQFYYIKGKNTMEWTKPPEQIDLTSRTAQLQVVMLYASQHGREFYKKCLDYYQLAMEYEGIKLDAPTYDEALAKYNANFNGVEDCDLLPAGYDEHRLDKIVFEN
What is the function of this protein?
Protease-polymerase processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved.  Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis.  This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap.  May cleave host polyadenylate-binding protein thereby inhibiting cellular translation.  It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals.  Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA.  This sgRNA codes for structural proteins.  Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
What are the official names of this protein?
Genome polyprotein.
Protein: RFT2_SALSA
Sequence: MTLLTHVLACLFGMGSWVAINGIWVELPLIVPEIPEGWYLPSYLTVLIQMANVGPLFVTLMHRFRPGKLDERPVIYSIVGLGVVATFLLAFFWKHTVPLAGATHSVPLLVLCFLLSVVDCTSSVTFLPFMMRLGPQYLTTYFVGEGVSGLVPAVVALVQGVGVVHCRNATVASLANGTLGVNSTVGASGELQAQYQPANFSAQVFFLFLSAMMVVCLAAFLLLNHHPAVAREKKCEQYFNGGLAEEKSDQALSLSHRPQEEKPMISSPDSHRRARQSSFGTGFYSGPELAFIFVVLAWVNALTNAVLPSVQSYSCLPYGNQAYHLAATMAAVANPVACFIAMFLPLRSLVLIGLLTIVGTGFGTYIMAMATLSPCPLLVHSASGTTLIVIAWVLFVLTLSYVKVIIGVILRDEGHSALVWCGAVVQLGSMLGALSMFPLVSVYGLFKSGDPCNTKCTK
What is the function of this protein?
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
What are the official names of this protein?
Riboflavin transporter 2, RFT2.
What is the protein family that this protein belongs to?
Belongs to the riboflavin transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HXB1_MACMU
Sequence: MDYNRMNSFLEYPLCNRGPSAYSAHSAHSAPTSFPPSSTQAVDSYASEGRYGGGLSSPAFQQNSGYPAQQPPSALGVPFPSSAPSGYAPAACSPSYGPSQYYPLGQSEGDGGYFHPTSYGAQLGGLSDGYGAGGAGPGPYPPQHPPYGNEQTASFAPAYADLLSEDKEAPCPSEPNTPTARTFDWMKVKRNPPKTGKVSEPGLGSPSGLRTNFTTRQLTELEKEFHFNKYLSRARRVEIAATLELNETQVKIWFQNRRMKQKKREREGGRVPPAPPGCPKEAAGDASDQSTCTSPEASPSSVTS
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Acts on the anterior body structures (By similarity).
What are the official names of this protein?
Homeobox protein Hox-B1.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Labial subfamily.
What are the subcellular locations of this protein?
Nucleus.