PharMolix/UniProtQA huggingface dataset:
Protein: SPNE_CULQU
Sequence: MDEAAGPSTSRTSNLEDVDDEGASLAEEDEEHTKALKAKEMMAPLFQRYNFTMKKNDLPINWNKPEILDKIRSNAVVVLQGATGCGKTTQVPQYLLEEAFERKEYCNIIVTQPRKIAAISIARRVAQERKCDLGTLVGYKVGLKEQHNEDTRLLYVTTGVLLQSLINSKTMATYTHVILDEVHEREVDMDFLLIVVRRLLSTNSKKTKVILMSATIDAKGFSEYFKIPKKSGYLSAPVISVERPRLHVVQEFYFDDLEKLKVDFQIDYEAPGISEQMYNIAAKLVVVCDHLKGQEFGDSLEYKPSIIIFLPGINEIEKMEGALEKLIASIQNAAQRPNLLIMKLHSTLPADDQTAVFRKPGPNQRKVILSTNIAESSITVPDIKFVIDFCLQRILVTDTLTNFSTLRTEWASKSNCIQRAGRAGRLMSGRVYRLVDRRFFENNMDVSTSPEILRCPLETVVLKAKLLEMGTPPSILALAMAPPNLDDIRNTILLLKEVGAMLRTVKGNYDQLDGDLTYLGRIMSKLPLDIRISKLIMLGYIFSVMEEAVTIGAGMNVKNIFLNQNSVKTYSQKMYWADGSGSDAIAILNAYTAWKSRQEQAGDTADMYNWARRMSLDRKSLIDMAELIHEVKDRLNRSGLKPVSGPNRVVWNAREKTVILKVILAGAFYPNYFIPMSVGGKELMERQSFTELGGRDPCNTVFFTGFDHERYIGPLYTVQIKKILSEGDYSKHQAMKVMYDRTTNRIFVTFLGTTDERDQRGSFMPGKVHADVYRAIKLRKLGARNRITEIRTMRQRDAIDYATSAGLGHWEDANGWVPRRKIVRNAHLSVLPPIFREKVVCQVTHVVHPNKFFLRPEDNRNKDIFREIHTQLNARQLHPFPADANFAMGQMVAAPVQENQETYARAVLRSYRNVRTTGSVSWTVFFIDYGHTAAMEETAFRQLDDSLGQLKDIPPRAFEATLTEIQPSAIISPQGSWTTESIHRFKELVLGKIFVAKVYSVVGVVASVELSRDEIRMNSELIRLKYAQYAEESYISKLDHDHRERKQREIMMDENLRNEVYRSAELTQNTYEDDELEDVNPPEDKLRCKVVLSGPHSPLETSASATIRSSVMKPVSIESDSVNSILLDSNPQDTHEKLLVAGGVNEQGNRLVLRQTSVMPNIPGFGAIMSLIFCPTAQLKKDKDETRVVTVLSGLGYDPSTGEALYPEHDMALTLDVVLNDDDITNINALRYTMDSILHTGEGQTDPKFGDASIQKLKLQVKQYIIKILEHERRFLDLRHAPNDYNWRCDLNLTAGSSSSKKMKGDFNIYDKKAIFPLLEPLNLLPVSASQLTFLKKHCHELHKLAHTDVQLPRHGITCQLCNNVLETLPQLRIHLYSKLHRDRESQIKYRSPQMY
What is the function of this protein?
Probable ATP-binding RNA helicase which plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).
What are the official names of this protein?
Probable ATP-dependent RNA helicase spindle-E.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis.
Protein: CONT_DROME
Sequence: MLAKIGLLASILVLNLVGQITPQFSENLPDPDPQSGQQPQNYQPSYNKDYSPRYNPLYTGQQSADPNQFDNTLVDGQSPNTYKGYYDGRAGGGGLGGNVVGPGNNLGGLGPQYDPFNRNSIGSAGVSYRDAYTDEDNFCPEHWVSFRQTCYRFIRSPKRNWAEAKKICKAHNADLINVDNVEKHSFILKNLILQNQRQNRFFISARQTGPLNWVNDDNTQLVQIEDSFSMDEQVPLENEDLHDNRFLVQNDLNNQNINNPNQFYNSLPGTVNQRNQNNLRGFIGPNQPYGDNRYVRDRVVYAFSKKRDRWMFMPAYEIELNLFICESKVLYSSDNVNIKLDDKRPYHYGLDINDMERIPRGPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETSEMNWGKSIFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAPVAGDEIRLECMAFGYPIPSYNWTRQGLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMSSPTLHFQMGKTTRNGANTRHGHNINTALILSTLLLISTFLYTSQ
What is the function of this protein?
Required for organization of septate junctions and paracellular barrier functions.  Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion.
What are the official names of this protein?
Contactin.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. Contactin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, septate junction. Note=Component of epithelial septate junctions. Nrx is required for its cell surface localization.
Protein: FADJ_SHESM
Sequence: MEKTFNLTRREDGIAILTMDVPGETMNTLKAEFGPEISEILSEIKRDSSIRGLVLISGKKDSFVAGADISMLDACQTAGDAKALSQQGHVVFNELEALNIPVVAAIHGACLGGGLELALACHQRVCSDDGKTMLGVPEVQLGLLPGGGGTQRLPRLVGITTALDMMLTGKQIRPKQALKMGLVNDVVPQTILLQTAVEMALAGKRTAKPVKKSLVNQLLEGTGFGRNIIFDQAAKQVAKKTQGNYPAPAKIIDCVRQGMAKGMQKGLEVEASHFAELVVSKESEALRSIFFATTEMKKETGAEGATPRKVKKAVILGGGLMGGGIASVTTTKAKIPARVKDINEKGLSNALSYAYKLLDKGVKRRHMTPAVRDNLMALMTTTTEYKGVKDADIVVEAVFEDLALKHQMVKDIERECGEHTIFASNTSSLPIGQIAQAASRPENVIGLHYFSPVEKMPLVEVIAHAKTSPETIATTVAFARKQGKTPIVVQDGAGFYVNRILALYMNEAAQLLLEGQSIEHLDKALVKFGFPVGPITLLDEVGIDVGAKIAPILEKELGERFKAPAAFDKLLSDDRKGRKNGKGFYQYAAGNKAPSKKKAVDESVYGVLGIKPGIDKEMSAVAERCVVQMLNEAVRCLDDGIIASPRDGDIGAIFGIGFPPFLGGPFHYIDTLGADNLVKILERYQAQYGDRFEPCPRLKEMAAEKTRFF
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_VIBA3
Sequence: MPRVKRGVQARARHKKVLKQAKGYYGARSRVYRVAFQAVTKAGQYAYRDRRNKKRQFRQLWIARINAASRQNGLSYSRFINGLKKASIEIDRKILADIAVFDKAAFAVLVEKAKASL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: MSCL_ECO55
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLAEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSI_STRVL
Sequence: MRRTLKAVGAAAAAATCVLAATAGTAQAEAPKAESLYAPSALVLTVGQGENAESAAVERAVTLTCAPRPGGTHPSAAAACAELAKVNGQFARLVGASSDAICTKEWRPVTVSVVGAWNGKHVNWTSTFANQCTMKAGLGEGAALTF
What is the function of this protein?
Strong inhibitor of bacterial serine proteases such as subtilisin.
What are the official names of this protein?
Subtilisin inhibitor.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I16 (SSI) family.
What are the subcellular locations of this protein?
Secreted.
Protein: VPS27_YEAST
Sequence: MSVSTPSELDALIEQATSESIPNGDLDLPIALEISDVLRSRRVNPKDSMRCIKKRILNTADNPNTQLSSWKLTNICVKNGGTPFIKEICSREFMDTMEHVILREDSNEELSELVKTILYELYVAFKNDSQLNYVAKVYDKLISRGIKFPEKLTLSNSPTAMFDSKTPADWIDSDACMICSKKFSLLNRKHHCRSCGGVFCQEHSSNSIPLPDLGIYEPVRVCDSCFEDYDLKRHDDSKKSKKHRHKRKKDRDYSTPEDEEELIRKAIELSLKESRNSASSEPIVPVVESKNEVKRQEIEEEEDPDLKAAIQESLREAEEAKLRSERQKASRQMQPQQPSPQPQPIHSVDLSDEEKDSIYMFASLVEKMKSRPLNEILEDSKLQNLAQRVFASKARLNYALNDKAQKYNTLIEMNGKISEIMNIYDRLLEQQLQSINLSQQYTLPQVPSDPYNYLTENVQNPAESYQTPPLQQLSSHQYKPQQDVSRQQSVKANSSPTTNIDHLKTIDVTPHAQQKPQSHVELAPSDPPYPKEEAEDEGTQAVQDEESSTQESRERPYPVETENGETSINKRPQGITRYDFPTVPARKFVQPESTVPLPASSSEIPIKEERPPSPQEELLIEL
What is the function of this protein?
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane (PubMed:3062374, PubMed:1493335, PubMed:9265642, PubMed:11416128, PubMed:12055639, PubMed:11872141, PubMed:12900393, PubMed:14581452, PubMed:15166140, PubMed:15107463, PubMed:15086794, PubMed:17135292, PubMed:18508771).  Controls exit from the prevacuolar compartment (PVC) in both the forward direction to the vacuole and the return to the Golgi (PubMed:11208109, PubMed:8649377, PubMed:9015300).  Allows VPS10 to return to the (trans-Golgi network) TGN from the PVC (PubMed:8649377).  Might also function as an alternate adapter in the COPIb clathrin-like coat (PubMed:17101773).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 27, Golgi retention defective protein 11.
What is the protein family that this protein belongs to?
Belongs to the VPS27 family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ARC_MYCA9
Sequence: MSESERSEAFGTPDAAEVERLRREVAALREQLEGSAARGPGDSGRLRDLNQLEARIDSLNARNAKLMDTLKEARQQLLALREEVDRLGQPPSGYGVLLAVQTDETVDVFTSGRKMRVTCSPNIETSELRRGQTVRLNEALTVVEAGNFESVGEISTLREVLDDGHRALVVGHADEERIVWLADPLIAPDLSEVSEDADGADLKPRKLRPGDSLLVDTKAGYAFERIPKAEVEDLVLEEVPDVSYSDIGGLARQIEQIRDAVELPFLHKDLYQEYSLRPPKGVLLYGPPGCGKTLIAKAVANSLAKKMAELRGDDSREAKSYFLNIKGPELLNKFVGETERHIRLIFQRAREKASDGTPVIVFFDEMDSIFRTRGTGVSSDVETTVVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAESAQDIFSKYLTVDLPVHSEDLAEFGGDRGLTVKAMIEKVVDRMYAEIDDNRFLEVTYANGDKEVMYFKDFNSGAMIQNVVDRAKKNAIKSVLETGQKGLRIQHLLDSIVDEFAENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKSSSASRAIDTESSLGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Mycobacterial proteasome ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: RL5_RICRS
Sequence: MLRFKELYQQKIIENLQKKFSYKNKHEIPQIKKIVINMGVGEATANSKVINNAVNDLTLISGQKPVVTLARKSIATFKLRENMKIGCKVTLRKDRMYDFLERLVIVALPRVKEFRGFSYKSFDGKGNFTFGLKEQIVFPEINYDKIDTIRGMDITIVTSAKTDQESKFLLSGFNLPFYN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: R3HD4_HUMAN
Sequence: MVALENPECGPEAAEGTPGGRRLLPLPSCLPALASSQVKRLSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGGLPGLEDGDLAPPASPGIFAEACNNATYVEVWNDFMNRSGEEQERVLRYLEDEGRSKARRRGPGRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAVCQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQHS
What are the official names of this protein?
R3H domain-containing protein 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS14_CHLPB
Sequence: MAKKSVIARNEKRKALVEKYAAKRDQLKKAGDYEALSKLPRDSASCRVRTRCVLTGRGRGVYEKFGLCRQMFRKLALEGKLPGIKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RSMA_SACD2
Sequence: MKNKNTDPMQGHRARKRFGQNFLEDQGIINAIVRSIGPKASDNLVEIGPGKGAITAQLIESCPSMQVVELDRDLIPILLAQFAIYNDFRIHQTDALKFDFGQLATPERPLRVVGNLPYNISTPLIFHLLSFGELIADMHFMLQKEVVLRLAAGPGDKNYGRLSVMTQYVCQVENLFEVPPECFNPRPKVDSAIVRLTPYRTQPFVAAHPDKLAKLVKTAFAQRRKTLRNNLKNLDEELDLEALDIDLTRRAESLSLEEYVNLSNTLWP
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZO26_XENLA
Sequence: IVGKSYSCTDCGRSFYAKGHLLNHQKNHGGEKRFTCTECGKIFTRKSNLRKHQRIHTGDNLFTCTECGKRFTEKRNLLIHQRIHTGEKPFTCTECGKSFNLWSTLRNHHKIHTGEKPFTCPECGKKFSVKNSLRKHQRTHARKKLFTCTECGKTFTKKSTFHMHQSTHTGEKPFTCTECGKSFAKNGNLRIHQMTH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Oocyte zinc finger protein XlCOF26.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TX23_ANDCR
Sequence: ADVPGNYPLDTRGYSYYCTILGENEFCKKICKVHGVSYGYCYNSGCWCEYLEAKDVSVWNAAKNYCKNPVGK
What is the function of this protein?
Binds to sodium channels (Nav) and affects the channel activation process.
What are the official names of this protein?
Toxin Acra II-3.
What is the protein family that this protein belongs to?
Belongs to the long (3 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DXS_BACHK
Sequence: MDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFDSPKDKFLWDVGHQSYVHKILTGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFEELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPAWSAVVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFPDRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDRSGLVGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGNGLGVHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPILTIEEACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: VP4_ROTSS
Sequence: MASLIYRQLLTNSYTVDLSDEIQEIGSTKSQNVTINPGPFAQTGYAPVNWGPGEINDSTTVEPLLDGPYQPMTFNPPVDYWMLLAPTTPGVIVEGTNNTDRWLATILIEPNVQSENRTYTIFGIQEQLTVSNTSQDQWKFIDVVKTTANGSIGQYGSLLSSPKLYAVMKHNEKLYTYEGQTPNARTGHYSTTNYDSVNMTAFCDFYIIPRSEESKCTEYINNGLPPIQNTRNVVPLSLTARDVIHYRAQANEDIVISKTSFWKEMQYNRDITIRFKFANTIIKSGGLGYKWSEISFKPANYQYTYTRDGEEVTAHTTCSVNGVNDFSFNGGSLPTDFVVSKFEVIKENSYVYIDYWDDSQAFRNVMYVRSLAANLNSVMCTGGSYNFSLPVGQWPVLTGGAVSLHSAGVTLSTQFTDFVSLNSLRFRFRLAVEEPHFKLTRTRLDRLYGLPAADPNNGKEYYEIAGRFSLISLVPSNDDYQTPIANSVTVRQDLERQLGELREEFNALSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSMATNVMKKFKKSGLANSVSTLTDSLSDAASSISRGSSIRSIGSSASAWTDVSTQITDISSSVSSVSTQTSTISRRLRLKEMATQTEGMNFDDISAAVLKTKIDKSTQISPNTIPDIVTEASEKFIPNRAYRVINNDDVFEAGIDGKFFAYKVDTFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGITKQQAFNLLRSDPRVLREFINQDNPIIRNRIEQLIMQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: PPI3A_ARATH
Sequence: MDEQIIFCDGFEVVPSPEINDLILYECDQSLTNSEVTTDEEEDTIFSGGDSSSGLAAEEDSSGDKPLSFYIVKQPVYDNPEIKAKIDEANQEIFRCNELRINVLSAKKSELAEVSSLYTQMESLVPQSEGYRMVIEEKKKEFDTLLEALRNLRCTTSDQLCFTKEELDHLSYIAQYQIEYGSIGLEEEDWMLKETEKPDGIILSEKEASINRVKSMALELNEVKNELDAITWKINDLSDKLWKSQNNIRVLDLEKAHILEKRDRFYARIKMLRIQRDKGNAAFFQSLSVMCKAKELAASGNVRELEVFASSEVDRFMTLWNDDKAFREDYVRRISHSLCERELNEDGRIKDADLQIFWEKKVPVKTIKRSEKVHKMNREDSSSNSSEDGNVITDKRKKETKSDVIVYEKPKKKEEEIDEEALKERKREEQLEKARLVMERKRKLQEKAAAKAAIRAQKEAEKKLKAIILSCSHFFNECEKKAKKKAAANSTSPSESDQVINDEKVRTLAVSGKEKHQKERLLFPKQRSFRYKHRGSGTEALPKAILNRRKARRYWVWGLSSAALAVSLVLVVLLLR
What is the function of this protein?
May regulate plasma membrane ATPase activity.
What are the official names of this protein?
Proton pump-interactor 3A.
What is the protein family that this protein belongs to?
Belongs to the plant Proton pump-interactor protein family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: ACPS_VIBPA
Sequence: MAILGLGTDIAEIERIEKALGRSGEPFAQRILSEDEMAKFSQLKQQGRYLAKRFAAKEAASKALGTGIAQGVTFHDFTVSNDELGKPVLMLSGVAQKMAQTMGVNHVHLSISDERHYAVATVILES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_BORBZ
Sequence: MDRYFFLQDATTVAKLLLGNLLIRKIDKEEIVTRIVETEAYMGITDSACHSYGGKITNRTSAMYRIGGYSYVYIIYGMHYMFNVVTADKNNPQAVLIRSVEPISPLLGEKSILTNGPGKLTKFLNIDLTFNKVDLIGNNELFLQRGLNLDFNIVCSKRININYAQESDINKLWRFYIKDNKFVSRR
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: MPL3_DICDI
Sequence: MGNSHSSENGGNSGSGGGSGGGGSGYSGVSENMIIDLEGRYHIDYKNRNYKKLKPQMFSTFFEHYEIVQADSLINSDFIKNKTVKKNRDNSSNNNSNNNSNNNNNNNTLNNSTIITTTTTTTTTSTPTTTIMITPPQQQQQQRTSLDLTNRDISESSTPNEQQIRLAQEETENQEIVESSFLKSSPVPSPSSSVLKSFESDFQLNTDLTTETFDDNSAEKKRQQQQQQQQNEDSKQSSQQQTQKSKDKDESAKIVNNKSSSTTNIKPILAAAQTSRSTSIPAFNRNKTKEPTKQKIKKEHSTLRKNSLSSSNIITPNNTTNTNAKDGASYFNENSLMSVKSDIKIFSLDLSINRLENITNDILSIMARFEIQELTLSTNFFQIIPDLQLVKSLTTVNLTRNKLSKLQTSVFIELPSLTSLILDRNFISSIPDDIDQIKNLKYLSIKHNALEYLPNSLSNLSQLISLDLSQNKLKTLPPNFDDLINLRMVWLSYNQITSLPSMRKLVNLVTFDISSNKLLSLPKDFAYLVPSRIKQSYSDIDIDEYDENINTCNNINSNNNDSNNSNNNNNNNNDNNNNCNKNNILEMINSTELEGGGLGCLKELNIRDNRELISLPVEYKQVESLMTLVTSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDDARDAPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTNILNISSHNSNNKNNNSSNNRKSINNRKSNNIIITINNSSNSNNNNSTDNSNNSSTSTTPNLSSLSSDSSSSASLSKLSISK
What is the function of this protein?
Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins.
What are the official names of this protein?
MAP kinase phosphatase with leucine-rich repeats protein 3.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Protein: ACKA_STAAM
Sequence: MSKLILAINAGSSSLKFQLIRMPEEELVTKGLIERIGLKDSIFTIEVNGEKVKTVQDIKDHVEAVDIMLDAFKAHNIINDINDIVGTGHRVVHGGEKFPESVAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLLRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTFGGLK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPF_NOCSJ
Sequence: MSGAMRRIGEYLGLLEDTGRYDDEYGDYAGDYETQETAPVATRSSKRESRPAPVSDLSERRRPASGPTGVVAELSRITTLHPSTYNEARTVGENFRDGTPVIMNLSEMDDADAKRLVDFAAGLVFATRGTIERITNKVFLLSPPNVSVAAEDKQRIAEGGFFNQS
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: 454R_IIV6
Sequence: MFSKSYQITKEMYEARGWQIIKEDELTILAKVNSRENTNPEFAIAKFIKTTQEIKSPPLSQIIDFSSNEYVCVTIICDGSITTNVKKIEQTTKGKVEIFHNKDLQMNITKYHLQPLFNKLLDEEAKDFKKKYIKCKIENGKKIILQSFPSMSKSDPIARFFKYQSGDVIKITNKDGFVSYRIVK
What is the function of this protein?
Component of the DNA-dependent RNA polymerase that catalyzes the transcription in the cytoplasm of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
Putative DNA-directed RNA polymerase subunit 454R.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.