PharMolix/UniProtQA huggingface dataset:
Protein: STR8_STRTC
Sequence: MSRLLCPSSSTSVVRRARPTFVLGNLSIKQAQGTGASSALARRRRSTFAATADGLHVIPLEQKYPFPWLRDACRCPDCVHPSTRQKLFCTSDIPVDIQPATNGVEEVGEGVKIRWSNGHESLYDWDFLKEHSSSVSRSEANKDLPRVGWTRASIAKERDLYLEYEELKTKEGLRKAIDHTCRFGLLFIRNVPNVETSTASCSLRTLAHYFGDIRTTFYGELWDVKNVSNSRNIAYTNLGLGLHMDLLYFQHPPQFQFLHCLRNRVQGGSSIFSDALHAAETLRIQDAASYSVLTDVQVPFFYVNDGHHLYHTHPTIEVSASGDVNQINYSPPFQAPLLLDTPPAFFTALHQFSNLVNSDENTYEYTLEEGDAVLFDNRRVLHARRAFEEIPGQGVRVGEANRWLKGCYIEGDTMWDRGRMLR
What is the function of this protein?
Dioxygenase; part of the gene cluster that mediates the biosynthesis of strobilurin A, an antifungal polyketide that contains a key beta-methoxyacrylate toxophore that targets the complex III of the mitochondrial electron transport chain (PubMed:30258052).  Strobilurin biosynthesis begins with construction of benzoyl CoA by step-wise elimination of ammonia from phenylalanine by the phenylalanine ammonia-lyase str11, oxygenation by str8 and retro-Claisen reaction to form benzoic acid, which is activated to its CoA thiolester benzoyl CoA by the dedicated CoA ligase str10 (PubMed:30258052).  Benzoyl CoA forms the starter unit for the highly reducing polyketide synthase stpks1 that produces the polyketide prestrobilutin A (PubMed:30258052).  The FAD-dependent oxygenase str9 then catalyzes the key oxidative rearrangement responsible for the creation of the beta-methoxyacrylate toxophore (PubMed:30258052).  Str9 performs epoxidation of the 2,3 olefin of prestrobilutin A, followed by Meinwald rearrangement to furnish the aldehyde intermediate (Probable).  Rapid enolization of the aldehyde intermediate would give the beta-methoxyacrylate skeleton and methylations catalyzed by str2 and str3 complete the synthesis and lead to the production of strobilurin A (Probable).  The short-chain dehydrogenase stl2 and the dehydrogenase str4 play a role in the shunt pathway leading to the production of bolineol (PubMed:30258052).  The cluster encodes no obvious halogenase gene that could be involved in production of strobilurin B, nor any obvious dimethylallyl-transferase that could be involved in the production of strobilurin G (Probable).  It is possible that unknown proteins encoded in, or near, the cluster (such as str1 or stl1) may form new classes of halogenases or dimethylally-transferases, or that the responsible genes are located elsewhere on the genome (Probable).  Similarly, proteins encoded by str5/str6 hydrolases appear to have no chemical role in the biosynthesis of strobilurin A (Probable).  Finally, no obvious self-resistance gene is found within the cluster (Probable).
What are the official names of this protein?
Dioxygenase str8, Strobilurin A biosynthesis cluster protein r8.
What is the protein family that this protein belongs to?
Belongs to the gamma-BBH/TMLD family.
Protein: SYS_THEMA
Sequence: MIDIKLIRQNPDFVKEALRKRGEDPAIIDEILKIDADWRATITKTNELRSRRNEISKNVARLKKEGKNAEAEALIEEGKRLGEEIKALEEKEKELQKKLNDLLLMIPNIPHESVPVGEDESQNVEVRRWGEPREFDFTPLAHWDLGPAWGLMDFSRASKLSGSRFTVMYGKLARLERALINFMLDVHTKEHGYTEVWVPHLVKRETITITGQLPKFEEELYLAERDDLFLIPTAEVPLAALHSGEILEEKELPKKYVSYTPCYRREAGSYGKDVRGMIRQHQFDKVELVWVTTPERSFEDLEELVKDAETILRKLELPYRVVSLCTGDLGFTSAKTYDIEVWLPSYNAYKEISSCSNVTDFQARRGNMRYRRRSDGKLEYVHTLNGSGIAVGRALVAILENYQQPDGSVRVPEVLVPYTGFEVIP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHX29_XENLA
Sequence: MGGKNKKNRHGSSTAVQGATAAANRPRAAAEPRPGGEDAAKKQTPRNSNVAPGSKESNKQGPKTYSFASSSDSGVSVNHDKSVLKVVIEAKLEKRIISLINEHKKLNSNKGTVSGRLTSKKLQDLYMALQKLSFKAEHIEEAMTNTVLYGGDLHAALDWLCLNLPDDALPEGFSQQFVEEEQRARAKFQAPPQRPSAANESATEKGEEGASLKGNPELTMKEWILRYAEQGSDDDDDDDDVKEEEKETTLEKFDPNERYLELTAKLLDARAQATATKQDKDKQGQKEAQERIRGYQQEMKSLEDHPLFNPAVKIPEVKSESKQPKPALPPSEDEPLNFNLFEKKENAPEEKAKKKPPLDIRNFDYTSRSWTGKSPKQFLIDWCRKHYSKSPNPSFEKVPVGKYWKSRVKIIKSHDDVMCVCPTIVTEDSMQAQHLAATLALYELTKGQSVHQLLPPTYRNVWLEWSDAEKQVQEQNKTESNKPRDQFITKLLNKLKVQQNQLKSCSQTQMMEDPEDSWENLACDEEQHETCPSPLLPDDLEPIRNIFRKSRDSMKYKRLLNDREQLPVFARGNFILETLKRHRVIVVAGETGSGKSTQVPQFLLEDLLFNGGSPGKCNIVCTQPRRISAMSLATRVCEELGCDSGPGGKNSLCGYQIRMESRTGEATRLLYCTTGILLRKLQEDSMLKNISHIIVDEVHERTVQSDFLLIILREILHKRSDLHLVLMSATVDCEKFSSYFTHCPIIRISGRTFPVEVFHLEDVVEATGFVLEQDSEYCQKFLEDEEEITLSVTGKGGSSKKYQEFIPAQSGTGLDLGARYQRYSSQTRHAVLYMNPNKINLDLILELLVFLDISPEYRNVEGAVLIFLPGLADIQQLYDILSSDKRFHDRRRYKLIALHSILSSQDQAEAFILPPAGTRKIVLATNIAETGITIPDVVFVIDAGRTKENRYHESSQMSSLVETFISKASALQRQGRAGRVRNGYCFRLYTRERFESFMEYSVPEILRVPLEELCLHIMKCDLGSPEDFLSKALDPPQLQVISNAMSLLRKIGACELSQPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDAVATLAATMTEKSPFVTPIGEKDRADLAKSSMAVANSDHVTIFRAYLGWKAIRPEGYAAEMSYCRKNFLNRKALLTIEDVKQELIRLVRAAGFECPRSVEANGLSSAMKALSAEETSLLKAILTAGLYDNVGKILFTKSVDITEKLACIVETAQGKAQVHPSSVNRDLQIYGWLLYQEKVKYSKVFLRETTLISPFPVLLFGGDIAVQHRERLLTVDDWIHFQAPVKIAVIFKELRILIESVLKQKLENPKMSLKDDMILNIIKELIKTER
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation.  Specifically binds to the 40S ribosome near the mRNA entrance.  Does not possess a processive helicase activity.
What are the official names of this protein?
ATP-dependent RNA helicase dhx29, DEAH box protein 29.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGD_MYCA9
Sequence: MARELKLGYKASAEQFAPRELVELAVATESHGFDSATVSDHFQPWRYNGGHAPFSLAWMTAVGERTQRLQLGTSVLTPTFRYNPAVTAQAFATMGCLYPGRIFLGVGTGEALNEIATGYIGEWPEFKERFARLRESVRLMRELWTGERVDFEGEYYRTQGAAIYDVPEGGIPVYIAAGGAVVAKYAGRAGDGFICTSGKGEELYSGKLIPAVREGAALAERSFDDIDRMIEIKISYDPDPDKALENTRFWAPLSLTPEQKHSIHDPIEMERAADELPIEQVAKRWIVASDPDEAVEKVADYVGWGLNHLVFHAPGHDQKRFLELFKTDLEPRLRKLG
What is the function of this protein?
Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.  Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.
What are the official names of this protein?
F420-dependent glucose-6-phosphate dehydrogenase, FGD, G6PD.
What is the protein family that this protein belongs to?
Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.
Protein: P3H1_RAT
Sequence: MVAVAAAAASRATAESEPEWNVAAPDLLYAEGTAAYARGDWPGVVLNMERALRSRAALRALRLRCRTRCATELPWAPDLDLGPASSLNHDPGAAALHDLRFFGALLRRAACLRRCLGPPSAHLLSEELDLEFNKRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMRQNLDYYQTMSGVKEEDFKDLEAKPHMHEFRLGVRLYSEEKPLEAVPHLEAALQEYFVADEECRALCEGPYDYDGYNYLDYSADLFQAITDHYVQVLSCKQNCVTELASHPSREKPFEDFLPSHYNYLQFAYYNIGNYTQAIECAKTYLLFFPNDEVMSQNLAYYTAVLGEEEASSISPRENAQEYRHRSLLEKELLFFAYDIFGIPFVDPDSWTPEEVIPKRLQEKQKSERETAVRISQEIGNLMKEIETLVEEKTKESLDVSRLTREGGPLLYEGINLTMNSKVLNGSQRVVMDGVISDDECQELQRLTNAAATSGDGYRGQTSPHTPNEKFYGVTVLKALKLGQEGKVPLQSAHMYYNVTEKVRRVMESYFRLDTPLYFSYSHLVCRTAIEESQAERKDSSHPVHVDNCILNAESLVCIKEPPAYTFRDYSAILYLNGDFDGGNFYFTELDAKTVTAEVQPQCGRAVGFSSGTENPHGVKAVTRGQRCAIALWFTLDPRHSERDRVQADDLVKMLFSPEEVDLPQEQPLPDQQGSPKPGEESLSDRESQPKDEL
What is the function of this protein?
Basement membrane-associated chondroitin sulfate proteoglycan (CSPG).  Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V.  May be involved in the secretory pathway of cells.  Has growth suppressive activity in fibroblasts (By similarity).
What are the official names of this protein?
Prolyl 3-hydroxylase 1, Leucine- and proline-enriched proteoglycan 1, Leprecan-1.
What is the protein family that this protein belongs to?
Belongs to the leprecan family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Secreted, extracellular space, extracellular matrix. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG).
Protein: RNPA_PSEA7
Sequence: MVSRDFDRDKRLLTARQFSAVFDSPTGKVPGKHVLLLARENGLDHPRLGLVIGKKNVKLAVQRNRLKRLIRESFRHNQEALAGWDIVMIARKGLGELENPELHQQFGKLWKRLLRNRPRTESPADAPGVADGTHA
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: TRPC_BUCSC
Sequence: MVLENILEKIVKSKINWIKHRKKIQPLSSFQHNITLSDRNFIQALKNIHPALILEFKKHSPSLGILNDFNPEFVAKIYKKYASAISVLTDEKYFHGKFEFIPIIRNIAVQQPILCKDFFIDPYQIYLARYYQADSILLMLSILKDNQYRALEKLAYSLNMAVLTEINNKMELDRAINLNAKIIGINNRNLKNFSISTSNTYKLASKISKNTIVISESGINSYNQLRKFKNLVQGFLIGSALMSKKDLEHAVHKIITGNNKICGLTRVEDARMSKDFGAIYGGFIFCKSSKRYVNLKKAMNITKNVHMKYIGVFCNENISTISYIIDKIPLYAIQLHGNENQFYIDCLKKKIPKCVRVWKAISLNGEKKHANNLFDNVNKHVFDNIHGGSGTPFNWYLLKNYNLKNVILAGGLNIKNCISASDLGCFGLDFNSGIEISPGLKDKKKTFLIFRSLREHKTIIH
What is the function of this protein?
Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway.  The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
What are the official names of this protein?
Tryptophan biosynthesis protein TrpCF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the TrpF family.
Protein: RL22_METVS
Sequence: MAKLGYKVEADPSKTAKAMGRTLRISKKHALEICREINGMKLETAVSFLNRVLALETPVPFKVHNKDVPHRKGKIGTHAGRFPQKATEEILKVLDNAKKNAEYKGLNTEKLRIKHISSNKGFIIKRFMPRAFGRASPKYQETIHIQVILEEFY
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: LEUC_PYRCJ
Sequence: MPTWTEYIFYKKLGKAPSPGDVVEVVPDLVGFHDLTGYHVLEVLEQMGKVEVFDRGRVVVAFDHLAPPPTQRAAELQVYIRRHVKALGLPHFYDVGGGILHQIILEKYAMPEQVIFAADSHTNTAGAVGAFAQGLGATDIAAALKLGKTWLVVPTPFAVRVVGEFPKGVMGKDVALHLLGAFGAEGFNGYSVEVTVEKPKAFPMDDRATVANMSTEMGADALVFIPDEVTVAYLHEARGVSYKPPALGGGKYADEYTVELGRLEPLVAAPHSVDNVKAVAEVEGIEVDQVFIGSCTNGRLSDIEVAAKILRHGRVKARCIAIPASYDVFRRAMELGYVDVLTKAGCVVTYGTCGPCLGGHFGVAGPGEVVLTTSNRNFKGRVGHPDSKVYLANPAVAAATALTGRITDPRQYL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: PRDX_CAEEL
Sequence: MSLAPKMSKAFIGKPAPQFKTQAVVDGEFVDVSLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSDRAEEFKAINTVVLAASTDSVFSHLAWINQPRKHGGLGEMNIPVLADTNHQISRDYGVLKEDEGIAFRGLFIIDPSQNLRQITINDLPVGRSVDETLRLVQAFQFVEKHGEVCPAGWTPGSDTIKPGVKESQEYFKKH
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:15099742).  In I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide (PubMed:25640076).  In the intestine, plays a role in protecting cells against oxidative stress by detoxifying peroxides such as hydrogen peroxide (PubMed:15099742, PubMed:19064914, PubMed:20649472).  In addition, plays a role in the recovery from oxidative stress induced by hydrogen peroxide (PubMed:20649472).  In its hyperoxidized form (induced by hydrogen peroxide), confers protection against heat stress (PubMed:19064914).  However, has a low tendency for overoxidation during the normal lifespan (PubMed:20964547).  Increases sensitivity to cytotoxity caused by metalloids and heavy metals such as arsenic and cadmium by playing a role in inhibiting the expression of phase II detoxification genes such as gcs-1 in intestinal cells (PubMed:19064914, PubMed:25204677).  In addition, in response to arsenite, promotes the secretion of the insulin ligand daf-28 into the pseudocoelom, which negatively regulates the activities of daf-16 and skn-1 (PubMed:25808059).  Plays a role in promoting longevity (PubMed:19064914, PubMed:24889636).  Plays a role in the mitohormetic pathway by promoting the activation of pmk-1 in response to the drug metformin (PubMed:24889636).
What are the official names of this protein?
Peroxiredoxin prdx-2, 2-Cys peroxiredoxin 2.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWP7_NOSB1
Sequence: MIKGLIYLFLFRCLEGRLADYEEESSDLGDYSLNGQTDEEYGKFPSHVLTEKETGPMDEIRCTNDDYTYNIKLNVHLQNYAIQAIADAAKPKLGMNLKERDAILSYFGTIANELNADLARLGAQIVIGLKHYKAEDFIDTNSFDTSCEIRDPVMDRLDSTFKQLKDVYQDSMGLRLFVWTCPQLTSSFETMKIMSNLNCGRIMGVLWQGADATRTSIKSTILEAISGVSELYLDGALPVDRVFSNVCRFCSKCVGVEPGVIGWKHPDVVKLIHAIPEEDTHEHGYDH
What is the function of this protein?
Involved in adherence of spores to the host cell surface and in infection efficiency.
What are the official names of this protein?
Spore wall protein 7.
What is the protein family that this protein belongs to?
Belongs to the SWP7 family.
What are the subcellular locations of this protein?
Cytoplasm. Spore wall. Spore polar tube. Note=Localized to the cytoplasm of sporonts and sporoblasts and to the spore wall and polar tube of mature spores.
Protein: RL22_LYSSC
Sequence: MTQAKAIARTVRIAPRKVRLVVDLIRGKQVGEAVAILRHTPKAASPVVEKVLKSAVANAEHNYDLDINSLVVSEVFVDEGPTLKRFRPRAQGRASAINKRTSHITLVVSEKKEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: ARGR_CROS8
Sequence: MRSSAKQEELVKAFKALLKEEKFSSQGEIVQALQDQGFENINQSKVSRMLTKFGAVRTRNAKMEMVYCLPVELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPARGFTVKDLYEAILVLFEQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C42S1_DANRE
Sequence: MSAFWHKIGCCVVAKPPPKKKRRRIDRSMIGEPTNFVHLTHIGSGEMADGMQPSGPIKEQMRSKVPHANGRNSLL
What is the function of this protein?
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
What are the official names of this protein?
CDC42 small effector protein 1.
What is the protein family that this protein belongs to?
Belongs to the CDC42SE/SPEC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor.
Protein: MIAA_MARMS
Sequence: MTKPYVVCLMGPTASGKTGLAVELAEHHNFEIISVDSALVYKGMDIGTAKPSAELLARAPHRLIDIIDPLEFYSAADFVLDAVEQSQEILAKGKTPLLVGGTMMYFNALQKGLAEMPQADAELRVIIEAEAAEKGWAALHEELQRFDPEAASRIHPNDPQRLQRAIEVYRLTGKTMTHFWRQQEAVSLPFEMINMAVMPKERSVLHERIEQRFYDMMDQGFLAEVEGFYRRGDLTIDMPSMRCVGYRQLWQYLDGVDLLEDAIFKGVVASRQLAKRQLTWLRGWEDLMIFDSLSKDLVPEALNYIESRII
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: PYRF_YERPB
Sequence: MTSATKTNNSGSISSPIVVALDYANKDAALAFADQVSPQDCRLKVGKEMFTLYGPELIRDLHQRGFDVFLDLKFHDIPNTTARAVAAAAELGVWMVNVHASGGARMMSAAKEALLPYGAQAPLLIAVTVLTSMDSEDLRDIGITISPAEQAERLAKLTWDCGLDGVVCSAHEAVRLKQVCGEDFSLVTPGIRPQGSEAGDQRRIMTPEQAVAVGVDYMVIGRPITQSPDPEKTLREILASLTKVA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: HEM1_CORA7
Sequence: MSVLVVGMSHQSAPVALLEKLSMDETVQNDTCRAMVSAGSLSEAMIISTCNRLEVYTVTNSFHSGVQDVVHNLAEVSGVEEEKLRSYLYVRYADAAAEHLMMVTSGLDSMVVGEQQIIGQVRTAYQFASEQGTVGPRIHALAQSALRTGKRVHSETEIDEAGSSMVSFAFDQALSRMGREDLAGKRVLILGAGAMASLAATHAGRLGAHLIIANRTIARAERVAQHAHEAGVYADVIDFSERAQALRDVDVAISATGAQGFTITAADVERYHVADRELMLVDLSLPRDIDDAVAEAEGVDLINIERLNNSLQAADTDLAAGTSPHAQARRIVSEELESYASEQRVRDVVPAVSALRKRAANLVQCEVARMEQKHPELDERQMGDINRALKRVADKLLHEPTVRAKQLAANSGTVSHETALQELFGLQLEGSGVAVDMAELPDAAQMEAAENTKEEKDA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PYRG_LACLA
Sequence: MSTKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVTNMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALRQMKAEVGADNVMYIHTVPILHLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQSLDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMTEWSAMVDHVMNLKKKVKIALVGKYVELPDAYISVTEALKHAGYSSDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGHRGTEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLEGAHSFELDPETKYPVIDIMRDQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKFREDFEKAGFVFSGVSPDNRLVEIVELSDKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ATP8_ALBTU
Sequence: MPQLSPINGFVILCSISLMLLTLLINGHFMLKPISSLTTPKLKMAYIKKLYF
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: CLIC3_HUMAN
Sequence: MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
What is the function of this protein?
Can insert into membranes and form chloride ion channels.  May participate in cellular growth control.
What are the official names of this protein?
Chloride intracellular channel protein 3.
What is the protein family that this protein belongs to?
Belongs to the chloride channel CLIC family.
What are the subcellular locations of this protein?
Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).
Protein: SL9A8_MACFA
Sequence: MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKARRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFMWLDAKYLNPFFTRRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL
What is the function of this protein?
Na(+)/H(+) antiporter.  Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry.  Acts as an Na(+)/H(+) exchanger in the trans-Golgi.  Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (By similarity).  In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity).  Can also be active at the cell surface of specialized cells.  In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells (By similarity).  Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins.  Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity).
What are the official names of this protein?
Sodium/hydrogen exchanger 8, Na(+)/H(+) exchanger 8, NHE-8, Solute carrier family 9 member 8.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.