PharMolix/UniProtQA huggingface dataset:
Protein: NUOB2_RHOPS
Sequence: MQQQASAMRPEGAQPLIARAPSGIIDPNTGKPVGADDPFFLGVNRELSDKGFFVAATDDLITWARTGSLMWMTFGLACCAVEMMQLSMPRYDAERFGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPIDIYVPGCPPTAEALLYGVMLLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 2, NADH dehydrogenase I subunit B 2, NDH-1 subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GHRB_SALEP
Sequence: MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVARHAQAFASAQGLLGASETVNRALLEKMPALRAASTISVGYDNVEVDALTARKIVLMHTPAVLTETVADTVMALMLATARRVVDVAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMALAQRAHFGFTMPVLYHARRRHQEAEDRFNARYCDLDTLLQEADFVCVILPLTAETRHLFGATQFARMKSSAIFINAGRGPVVDENALIAALQNGEIYAAGLDVFEQEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMACAVDNLIDALQGKIEKNCVNPQAAG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSSA_PARBD
Sequence: MAPSNLPPVFNATSQDIEMLLAAQCHLGSKNLQVHMEPYLWKTRPDGINVINIGKTWEKIVLAARIIAAIDNPADICVISARPYGQRAVLKFAAHTGAVAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDSQAIKEASYVNIPVIALCDTDSPTEFVDVAIPTNNKGRHAIGLIWWMLAREVLRLRGTLANRETEWDVVVDLYFYRDPEAEENKEIEETKVPGAEEVGAAAIESGLVGDSWQAQATPGFSAGVAVPGTAVPGWEADVSTDWAASSAPAAETLADPAADPSVKW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD_MARMM
Sequence: MADDMTQATEAPRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLLEHKTYLQGIGYFDRLDYVAPMNQEHAFCMAAEKLAGITVPKRGEYVRVLYCEIGRVLNHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGSRMHAHYFRPGGVHQDLPMKLVEDIRAWCDQFPAKLDDIDSLLTENRIFKQRNVDIGVVTKEDVLAWGFSGVMVRGSGLAWDLRRSQPYSVYDELKFDIPVGKNGDCYDRYLCRMEEMRESVKIMIQCCDWLMKDENAGEVLATDSKFSPPRRAEMKRSMEALIQHFKLYTEGVHVEEGETYVAVEAPKGEFGVYLVSDGSNKPYRLKIRAPGFAHLAAMDYMSKGHMLADVSAIIGSLDVVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AROC_THEPX
Sequence: MRYITAGESHGEALIAVIEGLPANLLIDEDFINKELKRRQGGHGRGKRMAIEEDKVHVLSGVSNGKTIGSPLAIQIINKDYENWKGKIVPAMTRPRPGHADLSGAIKYNQRDIRNVLERSSARETAARVAVGSVAKLLLKELNIFVKSKVLEIGGISVEEEWPKIIEEAKSKGDTLGGVIEIIIEGVPIGLGSHVQWDRKLDALLAYHVMSVQAIKGVEFGLGFEAARRPGSLVHDEIYYDKERGFYRKSNNAGGIEGGISNGSPIIIKAAMKPIPTLLKPLNSIDINSKKQVKAAYERSDVTAVEAAACVLEAVCAWVIADECLKKFGGDSIEELKKNYDAYLEYVKNF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RNZ_RIPO1
Sequence: MEITFLGTSSGVPTRSRNVSSVALRLPQRAEVWLFDCGEGTQHQLLRSDVKISQITRIFITHMHGDHIYGLMGLLASCGLAGNAQDIEIYGPPDLIDYLKACAKYSQVKLSHRVRVYGVRPGILYEDEEFTVSCGLLKHRIPAFGYRIAEKNRPGRFDVEKATALGIPPGPIYGQLKRGEVVTLPDGRRINGKDLCGETETGRKVIYCTDTVFCDGAVELAQDGDVLIHEATFAHQDAQLAFDRLHSTSTMAAQVALIAGVKQLIMTHFSPRYAPGNVLQLDDLLAEAKAIFANTILARDFMTYEVPRLRRKTE
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: PYRB_NEIMF
Sequence: MPNPLYRQHIISISDLSREQLECLLQTALKLKAHPRGDLLEGKLIGSCFFEPSTRTRLSFETAVQRLGGKVIGFSDGANTSAKKGETLADTARIISGYTDAIIQRHPKDGAARVAAEFSRVPVINAGDGTNQHPSQTLLDLVTIYETQGRLDKLKIAMAGDLKYGRTVHSLCQALKRWGCEFAFVSPPSLAMPDYITEELDEAGCRYRILGSLEEAAEWADILYMTRVQRERFDEQEFAKIQGKFNLDASMLARAKPNLRVLHPLPRVDEIHPDVDATPHAYYFEQATNGVYARMAILSLVLNEEV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: YG1J_SCHPO
Sequence: MVIDIVTNQFSNLQNIKIFTWKANFESIRINLQHMHLYHYEHIHLFTSSQSYMYHPNARFSYSPFCCFTDTLAYLRCEPYRGYRKCIYRKVKMPNLILRNPLVRYDVSPARYPTIGIRS
What are the official names of this protein?
Uncharacterized protein C83.19c.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus.
Protein: MT36_OCEIH
Sequence: MHQIYSATSTDKKLPEVVDLFSGCGGLALGFQLAGFNIRKGIELDRDASDVASFNLHWRQGKHDRHLNNDITLLSANEFYNDLDRKNDLIVIGGPPCQAYSKIGRAKLKSLGEERRQENDARGKLYENFLDYALHVDANVIVMENVPEAVNYGGVNIPDTVCDILINKGYDAIWTVLNAADFGVPQTRVRLFVMAIKKDIGKIKFIPEPTHKPHINVKRQSVNVRWMQSEIRNSKYYKQPNIPDETLSDWVTVGDAIGDLPNLFPVYNQKYKNYKPMMMKEYKSPPQNTFQKLMRINNKVDKVTGNMFRNTKRDFSIFDKMEEGDNYLDAHNIAMSLLRKEMRKSGITKENEFEYRLLKDRIVPPYSTEKFVEKWRKLSSDKPSHTLVAHLSTDTYSHLHPREPRGISVREAARLQSFPDDFLFDCSMGAAFKQIGNAVPPLLAKAIAEAMKKNIQGGCI
What is the function of this protein?
A methylase, recognizes the double-stranded sequence 5'-ACCGGT-3', methylates C-? on both strands.  No endonuclease has been identified for this methylase.
What are the official names of this protein?
Putative type II methyltransferase M.OihORF3336P, M.OihORF3336P, Cytosine-specific methyltransferase, Putative modification methylase OB3336.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Protein: VLDLR_RAT
Sequence: MGTSARWALWLLLALCWAPRDSGATASGKKAKCDSSQFQCTNGRCITLLWKCDGDEDCTDGSDEKNCVKKTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQCHMRTCRINEISCGARSTQCIPESWRCDGENDCDNGEDEENCGNITCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDCAPPTCGAHEFQCRTSSCIPLSWVCDDDADCSDQSDESLEQCGRQPVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDITKVCDQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIIYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQSTSTPVTYSETKDVNTTDILRTSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
What is the function of this protein?
Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism.  Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU.  In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8.  Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (By similarity).  This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons.  Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
What are the official names of this protein?
Very low-density lipoprotein receptor, VLDL receptor, VLDL-R.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.
Protein: QUEF_STAAR
Sequence: MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPITGQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEVWGKFTPRGGISIDPYTNYGRPNSKYEQMAEHRLMNHDLYPEKIDNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB14_HUMAN
Sequence: MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
What is the function of this protein?
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development.  Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.  May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity).  Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.
What are the official names of this protein?
Ras-related protein Rab-14.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Note=Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
Protein: RPPH_FRATH
Sequence: MIDKSGYRANVAIVLLNKQNRVFWGQRRNRTSWQFPQGGVATGETPLQAMYRELHEEIGLRPQDVEVIASTRDWYKYDIPDSLVRTKEPICIGQKQKWFLLKLKSPESYIDLDANDSPEFDNWRWVSYWYPINHVVYFKQEVYRKALTYFKEYIA
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: YTET_BACSU
Sequence: MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAVCKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEKPMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWYIDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPDSEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPDACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEPSRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILAGAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV
What is the function of this protein?
May play a role in the degradation of type I rhamnogalacturonan derived from plant cell walls.
What are the official names of this protein?
Putative oxidoreductase YteT.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: PDXA2_HALH5
Sequence: MNKKPIIAIPMGDPAGIGPEITVGALNKKELYDVANPVVIGHGDMLEKMLPVMKADLTINRITTVDEAMFEYGTIDVIHLDNLNVAEVKMGTVQAQCGKAAFEYIRHAVQLANDKKVDALATTPINKESLKAAEVPYIGHTEMLADLTKTEDPLTMFEVHSMRIFFLTRHLSLKDAIDQMTKERVHDYLLRCDKALEKLGVKERRFAVAGLNPHSGENGLFGREEMDEITPGIELAKKDGINAVGPVPADSVFHHALNGRYDAVLSLYHDQGHIAAKMTDFERTISITNGLPFLRTSVDHGTAFDIAGKGIASTVSMEECIKLAAKYAPHFVTA
What is the function of this protein?
Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).
What are the official names of this protein?
Putative D-threonate 4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family. PdxA2 subfamily.
Protein: H42_BLEJA
Sequence: KGLGKVGAKKRHRRVIRENNQGITKPAIRRLARRGGVKRTLSGLVYDETRNVLKVFLESVVRDAVTYTEHAKRETVTALDVVYALKRQG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PA2HD_PSETE
Sequence: MHPAHLLVLLGVCVSLLGAASIPRPSLNIMLFGNMIQCTIPCEQSWLGYLDYGCYCGSGSSGIPVDDVDKCCKTHDECYYKAGQIPGCSVQPNEVFNVDYSYECNEGQLTCNESNNECEMAVCNCDRAAAICFARFPYNKNYWSINTEIHCR
What is the function of this protein?
Snake venom oligomeric phospholipase A2 that has potent presynaptic neurotoxicity.  Chain D is not itself neurotoxic, but it is essential for the neurotoxicity of textilotoxin.  Chain D possesses a very low phospholipase activity.
What are the official names of this protein?
Acidic phospholipase A2 homolog textilotoxin D chain, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL9_FRAAA
Sequence: MKLILTQEVPGLGSPGDIVEVANGYGRNYLVPRKYAILATKGAERQVEQIKRARSARAVRDLGHAQEIAGQLGGLKVELISRAGKEGRLFGSVTAADVVEAVTAAGGPELDRRRVELTTPIKSLGAYTVAVHLHPEVTASVKLQVKKA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: FLIA_SALTI
Sequence: MNSLYTAEGVMDKHSLWQRYVPLVRHEALRLQVRLPASVELDDLLQAGGIGLLNAVDRYDALQGTAFTTYAVQRIRGAMLDELRSRDWVPRSVRRNAREVAQAMGQLEQELGRNATETEVAERLGIPVAEYRQMLLDTNNSQLFSYDEWREEHGDSIELVTEEHQQENPLHQLLEGDLRQRVMDAIESLPEREQLVLTLYYQEELNLKEIGAVLEVGESRVSQLHSQAIKRLRTKLGKL
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor controls the expression of flagella-related genes.
What are the official names of this protein?
RNA polymerase sigma factor FliA, RNA polymerase sigma factor for flagellar operon, Sigma F, Sigma-28.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. FliA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCK_MACFA
Sequence: MGCMKSKFLQAGGNTFSKTETSANPHCPVYVPDPTSTIKPGPNSNNRNTPGIGEGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGSDGLCQKLSVPCVSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSSTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
What is the function of this protein?
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration.  Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2.  During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst.  Plays a role in the release of inflammatory molecules.  Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions.  Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis.  Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors.  Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase HCK, Hematopoietic cell kinase, Hemopoietic cell kinase, p56-HCK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol. Cell membrane; Lipid- anchor. Membrane, caveola; Lipid-anchor. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasmic vesicle. Lysosome. Nucleus. Note=A small fraction is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions (By similarity).
Protein: K2C74_MOUSE
Sequence: MASCHTAGHRTGLSSRSLYSLGGNQHTSYNVAGGSARGTRHSFGYGYGGGRGSGFANSMFGSMALGANCPSVCLSGGIYQVTVNKSLLAPLNVELDPEIQKVRAQEREQIKALNDKFASFIDKVRFLEQQNQVLQTKWELLQQLDLSNCRRNLEPVYEAHISNLRKQLEMLSGERVRLDPDLRKMRDVVEDYKKRYEVEITQRTAAENEFVLLKKDADAAYTVKVELQDKVDSLDKDIKFLKCLYDEEISQLQTHASETSVILSMDNNRDLDLAGIIAEVRAHYEDIALKSKAEAEMLYQTKIQELQLAAGCYGDSLKHIRSEMLELDRLIQRIRCDIANVKKQCSNLEMAIADAEQRGDSALKDAWAKLDELEGALQQAKEELARMLCEYQELMGLKLSLDVEIATYRKLLEGEENRMSGENPSSVSVSVISSSCGSCGYHPSSMISDSEAGNAVGSPSTPRNSQSKTRGSSVDPRDAQDESAAAAGTLARKTT
What is the function of this protein?
Has a role in hair formation.  Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).
What are the official names of this protein?
Keratin, type II cytoskeletal 74, Keratin-74, K74, Type-II keratin Kb37.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: PLSX_BACC7
Sequence: MKIAIDAMGGDHAPKAVVLGAMKAIKEYSDLHITLVGKEEEIRQYLTSEERITILHTDEKIESTDEPVRAVRRKKQASMVLAAQQVKDGVADACISAGSTGALMAAGLFVVGRMEGIERPALSPTMPTVDGEGFVMLDVGANVDAKPIHLYQYAVMGSVYAEKVRGIKNPRVGLLNVGTEDGKGNELSKQVFAMLKDAPINFVGNVESRDLLQGVADVVVCDGFTGNVALKSLEGTALALFSMLKEQLMSSFTSKLAAAVLKPKLMVLKDKMDYSEYGGAALFGLKAPVIKAHGSSNDQSIFSAIRQTREMVAKEVIPTISSVMEKEPLQ
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RLME_PICTO
Sequence: MNRKDKYYIRAKRENYRSRASYKIIEINNKYNIVSRGDNVLEFGSSPGGWTQVIENITQSVIIAVDINRMDPVKNTVFIKMNIFDDDIFKSIDHAMAENNIKNFDSILSDAMSRTSGIEDRDHYNSYKICERVMDISIPRLKNGGNIILKQFQGDMTNEFIKKWSGYFNYYKITKPKASRQHSREIYIIFLNRI
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTA_ECODH
Sequence: MMVIRPVERSDVSALMQLASKTGGGLTSLPANEATLSARIERAIKTWQGELPKSEQGYVFVLEDSETGTVAGICAIEVAVGLNDPWYNYRVGTLVHASKELNVYNALPTLFLSNDHTGSSELCTLFLDPDWRKEGNGYLLSKSRFMFMAAFRDKFNDKVVAEMRGVIDEHGYSPFWQSLGKRFFSMDFSRADFLCGTGQKAFIAELMPKHPIYTHFLSQEAQDVIGQVHPQTAPARAVLEKEGFRYRNYIDIFDGGPTLECDIDRVRAIRKSRLVEVAEGQPAQGDFPACLVANENYHHFRVVLVRTDPATERLILTAAQLDALKCHAGDRVRLVRLCAEEKTA
What is the function of this protein?
Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.
What are the official names of this protein?
Arginine N-succinyltransferase, AST, AOST.
What is the protein family that this protein belongs to?
Belongs to the arginine N-succinyltransferase family.