PharMolix/UniProtQA huggingface dataset:
Protein: RAPA_ECOL5
Sequence: MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNDLINYLASPDETEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTNLIAFAMNLFDIIGINQDDRGDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQVMESLDQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: ARHG2_MOUSE
Sequence: MSRIESLTRARIDRSKEQATKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLRNNTALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGSRRGLSSLSLAKSVSTTNIAGHFNDESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSWSLAVDSSFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEVVQGLFPCVDELSDIHTRFLNQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPVLINRILQNSHGVEEEYQDLASALGLVKELLSNVDQDVHELEKEARLQEIYNRMDPRAQTPVPGKGPFGRDELLRRKLIHEGCLLWKTATGRFKDVLLLLMTDVLVFLQEKDQKYIFTSLDKPSVVSLQNLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRLCPSREDFPLIETEDKAYLRRIKTKLQQKNQALVELLQKNVELFAEMVHFQALKAGFVGMPPPALPRGLFRLESFESLRGERLLKDALREVEGLKDLLLGPCVDLPMTSREPALPLDSDSGSCPGVTANGEARTFNGSIELCRADSDSSQKDRNGNQLRSPQEEVLQPLINLYGLLHGLQAVVVQQERLMEALFPEGPERWEKLSRANSRDGEAGRAAVASVTPEKQATELALLQRQHTLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIRRQLAALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPVTVRSLHRPFDDREAQELGSPEDRLQDSSDPDTGSEEEVSSRLSPPHSPRDFTRMQDIPEETESRDGEPTASES
What is the function of this protein?
Activates Rho-GTPases by promoting the exchange of GDP for GTP.  May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer.  Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases.  May stimulate instead the cortical activity of Rac.  Inactive toward CDC42, TC10, or Ras-GTPases.  Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens.  Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase.  Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.  Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity).  Involved in neuronal progenitor cell division and differentiation (PubMed:28453519).  Involved in the migration of precerebellar neurons (PubMed:28453519).
What are the official names of this protein?
Rho guanine nucleotide exchange factor 2, Guanine nucleotide exchange factor H1, GEF-H1, LBC'S first cousin, Lymphoid blast crisis-like 1, Oncogene LFC, Rhobin.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (By similarity). Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (By similarity). Associated with apical intercellular junctions in the trophectoderm of the blastocyst (PubMed:12604587).
Protein: RS15_LEPIC
Sequence: MIATEQKKQIISNFARKAGDTGSTEVQIALIDARIKELNEHFKTHKKDFHSKTGLLRLVGKRKKLLDYLKRTELERYKKLIETLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RIMO_BDEBA
Sequence: MKQETAQNKKVHFISLGCPKNLVDSEIMAGTLMKDGYEVVGEADQADTVIVNTCGFIEDSKKESIQRILDMSDLKQEGKIKKVVVAGCLTQRYKDDLVEGLPEADLFVGSGEFQNIAKILKNSDEGEKQKTFFNLPTYLQEEATPRVNSQPGHRAYLKISEGCMKRCAFCAIPLIRGNLQSRSIDAIVAEAKLLVAGGVKELIIISHDFTDYGFDIRRKDPTRKESPVELLKALDQVEGLQWIRLMYLYPDGITQEMVQVIKNSTKIVKYFDMPLQHVNDQVLKSMNRKMTRDEIETALMNIREHLPEAVIRTQFIVGFPGETQEQFEELLNFVAEQQFDRVGCFKYSPEENTPGGRMENQIDEETKQYRHDALMEVQQNISREKHSDFVGKTLQVIVEGFSEETDLLLQGRFWGQAPDIDGVVLINDGQAQVGDMVKVHITDNMEYDLIGEIVVEN
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHST7_RAT
Sequence: MKGRRRRRREYCKFTLLLALYTLLLLLVPSVLDSGSEQDKGGRDCPGLQRSLGVWSLEAAAAGEREQGAEVRFQAEGNPDRSPRPQGNLSAIRESVTQEKQHIYVHATWRTGSSFLGELFNQHPDVFYLYEPMWHLWQALYPGNAESLQGALRDMLRSLFRCDFSVLRLYAQPGDPAERAPDSANLTTAMLFRWRTNKVICSPPLCPAAPRARADVGLVEDKACESTCPPVPLRALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQLFRDPRAVHNSRLKSRHGLLRESIQVLRTRQRGDRFQRVLLAHGVGARPGGQSRALPSAPRADFFLTSALEVICEAWLRDLLFTRGAPTWLRRRYLRLRYEDLVWQPQVQLRRLLRFSGLRTLAALDAFAFNMTRGSAYGADRPFHLSARDAREAVHAWRERLSQEQVRQVEAACDPAMRLLAYPRSGDERDVKTVRKGETPLETNANWAT
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues.  Preferentially acts on mannose-linked GlcNAc.  Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin.  Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency.  Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc.  Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc (By similarity).
What are the official names of this protein?
Carbohydrate sulfotransferase 7, Chondroitin 6-sulfotransferase 2, C6ST-2, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5, GST-5, N-acetylglucosamine 6-O-sulfotransferase 4, GlcNAc6ST-4, Gn6st-4.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: U88B1_STERE
Sequence: MESSKVILYPSPGIGHLVSMVELGKLIHTHHPSLSVIILVLPATYETGSTTTYINTVSTTTPFITFHHLPVIPLPPDSSSEFIDLAFDIPQLYNPVVYNTLVAISETSTIKAVILDFFVNAAFQISKSLDLPTYYFFTSGASGLCAFLHLPTIYKTYSGNFKDLDTFINIPGVPPIHSSDMPTVLFDKESNSYKNFVKTSNNMAKSSGVIANSFLQLEERAAQTLRDGKSITDGPSPPIYLIGPLIASGNQVDHNENECLKWLNTQPSKSVVFLCFGSQGVFKKEQLKEIAVGLERSGQRFLWVVRKPPSDGGKEFGLDDVLPEGFVARTKEKGLVVKNWAPQPAILGHESVGGFVSHCGWNSSLEAVVFGVPMVAWPLYAEQKMNRVYLVEEIKVALWLRMSADGFVSAEAVEETVRQLMDGRRVRERILEMSTKAKAAVEDGGSSRVDFFKLTESWTHK
What is the function of this protein?
May glycosylate diterpenes or flavonols in leaves.
What are the official names of this protein?
UDP-glycosyltransferase 88B1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: YCJF_ECO57
Sequence: MTEPLKPRIDFDGPLEVEQNPKFRAQQTFDENQAQNFAPATLDEAQEEEGQVEAVMDAALRPKRSLWRKMVMGGLALFGASVVGQGVQWTMNAWQTQDWVALGGCAAGALIIGAGVGSVVTEWRRLWRLRQRAHERDEARDLLHSHGTGKGRAFCEKLAQQAGIDQSHPALQRWYASIHETQNDREVVSLYAHLVQPVLDAQARREISRSAAESTLMIAVSPLALVDMAFIAWRNLRLINRIATLYGIELGYYSRLRLFKLVLLNIAFAGASELVREVGMDWMSQDLAARLSTRAAQGIGAGLLTARLGIKAMELCRPLPWIDDDKPRLGDFRRQLIGQVKETLQKGKTPSEK
What are the official names of this protein?
UPF0283 membrane protein YcjF.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KTHY_STRZJ
Sequence: MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGVLIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSSVAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDLEGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKAVLFDGMGLAK
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: DLYKI_THEX4
Sequence: MLTKELVKEAREKAIRMLEKACIAITDEEKEKIEVTDFGLGVLYTFGLEILVYVNNERYCAKELVMFPRQICPEHRHPPIGSYLGKQETFRCRWGEVYLYVPGTPTPNPRARIPEEKKRYFTVWHEIVLRPGEQYTIPPNTLHWFQAGDEGAIVSEFSSQSIDEKDIFTDPNVKRIPEIV
What is the function of this protein?
Sugar isomerase that catalyzes the reversible isomerization of D-lyxose to D-xylulose (PubMed:34422783).  Is highly specific for the substrate D-lyxose, showing less than 2% activity towards mannose and other substrates reported for lyxose isomerases (PubMed:34422783).
What are the official names of this protein?
D-lyxose ketol-isomerase, D-lyxose isomerase.
What is the protein family that this protein belongs to?
Belongs to the D-lyxose ketol-isomerase family.
Protein: VPC21_MYCTU
Sequence: MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEIQEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase (By similarity).  Upon expression in M. smegmatis inhibits colony formation.  Its toxic effect is neutralized by coexpression with cognate antitoxin VapB21.
What are the official names of this protein?
Ribonuclease VapC21, RNase VapC21, Toxin VapC21.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: UCK2B_DANRE
Sequence: MAGDSETHLKDRAENGHAVRQPFLIGVSGGTASGKSSVCEKIMELLGQNKIDRHQRQVVILSQDSFYRELTPEQKAKAVKGQFNFDHPDAFDSELIMKTLRDIIQGKTVHIPVYDFVTHSRKDEFLTLYPADVVLFEGILMFYSQEIRDLFKMKLFVDTDPDTRLSRRVLRDISERGRELEQVLNQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGFTKRQNGFQNGHGTPRQRRTSESSRPH
What is the function of this protein?
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate.  Does not phosphorylate deoxyribonucleosides or purine ribonucleosides.  Can use ATP or GTP as a phosphate donor.
What are the official names of this protein?
Uridine-cytidine kinase 2-B, UCK 2-B, Cytidine monophosphokinase 2-B, Uridine monophosphokinase 2-B.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
Protein: Y545_NAUPA
Sequence: MAEKIAKKLNINEKTVVECKEFEVIEGNLDNSLWIMHINNEFKIVLDVEEYMKLMETMKNVMKENFELKLEKAILSEFPVDYDDVKAVVLEEMKRDENASISEILNKVKLEHPNLFYNLDLEKIF
What are the official names of this protein?
UPF0763 protein NAMH_0545.
What is the protein family that this protein belongs to?
Belongs to the UPF0763 family.
Protein: THA_SPAAU
Sequence: IEENRQRRKREEMVRTLQTRPEPNTAEWELIRMVTEAHRHTNAQGSSWKQKRKFLSDDIGQGPVVPTSEGDKVDLEAFSEFTKIMTPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVR
What is the function of this protein?
Nuclear hormone receptor that can act as a repressor or activator of transcription.  High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
What are the official names of this protein?
Thyroid hormone receptor alpha, Nuclear receptor subfamily 1 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: COBQ_THEGJ
Sequence: MGKALMVLGTSSGAGKSLLVTALCRIFSNLGYDVVPFKSQNMSLNSAPSIEGGEISRAQYLQAIACRKKPSVRFNPILLKPEGNMRSQVIFMGKPIGSVSAKDYMLSRKEELFRKAMKVLDELKERHDLVIIEGAGSPVEINLKDYDIANTRVMLHAKAKGILVTDIDRGGSFASIVGTMELLKPEERDTIIGFVFNKFRGDKSLLEPGFEYLEKRYGKPTLGVIPYVEHRLPEEDSLAEFPKVKGELHIQIIKLPHISNFTDFEPLHWANGVDYVTRPEELKGDVIIIPGSKNTVEDLLWLRENGFEDAIIEAHREGSFVVGICGGFQMLGEKIIDTVESKRGEVKGIGLLPAKTVFEKTKRTNHLNAEVLWEPARGMAVEGYEIRFGRSVSERPFSVIKAINGAKTFEPEGAIGERAFGTYLHGIFHNFAFTERFLNFLRVEKGLEPVSIERWSIEEEIERFAKLVEENIDVERILGELGL
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Probable cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: NDHI_VENCA
Sequence: MFPMVTEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTIFNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: VGFR3_MOUSE
Sequence: MQPGAALNLRLWLCLGLLQGLANGYSMTPPTLNITEDSYVIDTGDSLSISCRGQHPLEWTWPGAQEVLTTGGKDSEDTRVVHDCEGTEARPYCKVLLLAQTHANNTGSYHCYYKYIKARIEGTTAASTYVFVRDFKHPFINKPDTLLVNRKDSMWVPCLVSIPGLNITLRSQSSALHPDGQEVLWDDRRGMRVPTQLLRDALYLQCETTWGDQNFLSNLFVVHITGNELYDIQLYPKKSMELLVGEKLVLNCTVWAEFDSGVTFDWDYPGKQAERAKWVPERRSQQTHTELSSILTIHNVSQNDLGPYVCEANNGIQRFRESTEVIVHEKPFISVEWLKGPVLEATAGDELVKLPVKLAAYPPPEFQWYKDRKAVTGRHNPHALVLKEVTEASAGVYTLALWNSAAGLRQNISLELVVNVPPHIHEKEASSPSIYSRHSRQTLTCTAYGVPQPLSVQWHWRPWTPCKTFAQRSLRRRQQRDGMPQCRDWKEVTTQDAVNPIESLDSWTEFVEGKNKTVSKLVIQDANVSAMYKCVVVNKVGQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRSQDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMRCPVAGAHVPSIVWYKDERLLEKESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILIGTGVIAVFFWVLLLLIFCNMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEERMALHSSQSSEEDGFMQASTTALHITEADADDSPPSMHCHSLAARYYNCVSFPGRLARGTKTPGSSRMKTFEELPMTPTTYKASMDNQTDSGMVLASEEFEELESRHRPEGSFSCKGPGQHMDIPRGHPDPQGRRRRPTQGAQGGKVFYNNEYGEVSQPCTEGDCCPSAGSTFFADSSY
What is the function of this protein?
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development.  Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting.  Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling.  Modulates KDR signaling by forming heterodimers.  Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway.  Phosphorylates SHC1.  Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase.  Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
What are the official names of this protein?
Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, FLT-4, Tyrosine-protein kinase receptor FLT4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=Ligand-mediated autophosphorylation leads to rapid internalization.
Protein: NUOC_METS4
Sequence: MTNGITILPHTETEHGTGALQALSDRLAETLGGAVVERAIAFDELTLVVEPSEIVRVLTHLRDDPACGFRSFIDICGADYPGREKRFDVVYHLLSLRHNRRIRVKVQTDEATPVPSVITVFPAANWYERETYDLYGILFSGHPDLRRLLTDYGFEGHPLRKDFPLTGFVEVRYDQDEGRVVYEPVKLSQEFRQFDFLSPWEGTDYVLPGDEKAKP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: IRC22_YEAS8
Sequence: MRFSMLIGFNLLTALSSFCAAISANNSDNVEHEQEVAEAVAPPSINIEVKYDVVGKESENHDSFLEFYAEDTATLAYNVTNWEDTNITIFGVNGTIVTYPHGYPVADITGASIGPYEMEVNGTSKFGQDVTLNLPEGQYFLIPFLLASRFDEIVRIAAPPTLFEIVSPPISFFNPQFLSVQVIFLAIIGGVSYYYMKSKTNQRPSKKSATVKKVDESWLPETYKK
What is the function of this protein?
Is probably involved in a pathway contributing to genomic integrity.
What are the official names of this protein?
Increased recombination centers protein 22.
What is the protein family that this protein belongs to?
Belongs to the IRC22 family.
Protein: M2_I02A1
Sequence: ETPTRTGWECKCSDSSDPLVVAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTGGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion) (By similarity).
Protein: Y838_METJA
Sequence: MKVAILTDGVYGDRAYNTIKSKFPCDFITVKYYGDFDEITISENTIEKLKDYDLFITYTLNPDLTYELVRKIKELNNKAFVLVGAWKGEGFKKQIESFGNAFCPYLMCDIDEDELKDYKDYLDNYPHLKEFLKYFGKPKVKLYIKNNKIEKIDVLREAPCGSTSETLKEFVGREFNDKTLIDIGLRVQHFCRAGKIRLFVEKEGKKTKAGKILVSGIQVIQIP
What are the official names of this protein?
Uncharacterized protein MJ0838.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0575.
Protein: RUVC_NOVAD
Sequence: MIILGIDPGLTVTGWGVVAKSGSRLSHVANGQIRTDNKATMAERLVELDSALAAVIDIYKPDTGAVEEVFVNVNPQSTLKLGQARGVAMVAVARSGIPVAEYPTKVIKKALVGTGGAEKQQIQHMLKILLPGVQLAGEDASDALAVAITHANMLGSHR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: YL897_MIMIV
Sequence: MKIPRINHNDLFAIVIKLRQYIQDNKIDNEINIVDLIDLIDSMIENKTSEIKFDTVTFEIFTDISLIYYTNKISDINIFLDHNFYSRDNEYYTYFALSIGAMDVFKWLISHGFSYDMSKILNYLHKNCGMSIFRKIFDDDFLNMDNSIINNAVKSAYSNEIEEYVDYFIRSNHVVKITRENIIDVIEYAVQINNCDIIKILVKKFIFWANDYRKIFIQAVRNNNFTITKTLLHSIMYRTNKETLIKFNKNEALKYAIMMKNYDMIELLINYNIQTDHVVKYHIEGALDIKNDDHLDKILKYIDEIVCKKCSKKNREVVIIGF
What are the official names of this protein?
Putative ankyrin repeat protein L897.
Protein: CLPP_COXBR
Sequence: MSVLVPMVVEQTSRGERAYDIYSRLLKDRVIFLVGQVEDHMANLAIAQMLFLESENPNKDINLYINSPGGAVTSAMAIYDTMQFVKPDVRTLCIGQAASAGALLLAGGAKGKRHCLPHSSVMIHQVLGGYQGQGTDIQIHAKQTQRVSDQLNQILAKHTGKDIERVEKDTNRDYFLTPEEAVEYGLIDSIFKERP
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.