PharMolix/UniProtQA huggingface dataset:
Protein: RHAR_SALPB
Sequence: MANQLILLKKDFFTDEQQAVTVADRYPQDVFAEHTHEFCELVMVWRGNGLHVLNERPYRITRGDLFYIRAEDKHSYTSVNDLVLQNIIYCPERLKLNVNWQAMIPGFQGAQWHPHWRLGSMGMNQARQVINQLEHESNGRDPLANEMAELLFGQLVMTLKRHRYATDDLPATSRETLLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWRHLSNQSD
What is the function of this protein?
Activates expression of the rhaSR operon in response to L-rhamnose.
What are the official names of this protein?
HTH-type transcriptional activator RhaR, L-rhamnose operon transcriptional activator RhaR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IGA1A_STRPN
Sequence: MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAAMGILIFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSESEVSNQKSSVATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETMETKIDFQEEIQENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPSPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAIQPELPEAVVSDKGEPEVQPTLPEAVVTDKGETEVQPESPDTVVSDKGEPEQVAPLPEYKGNIEQVKPETPVEKTKEQGPEKTEEVPVKPTEETPVNPNEGTTEGTSIQEAENPVQPAEESTTNSEKVSPDTSSKNTGEVSSNPSDSTTSVGESNKPEHNDSKNENSEKTVEEVPVNPNEGTVEGTSNQETEKPVQPAEETQTNSGKIANENTGEVSNKPSDSKPPVEESNQPEKNGTATKPENSGNTTSENGQTEPEPSNGNSTEDVSTESNTSNSNGNEEIKQENELDPDKKVEEPEKTLELRNVSDLELYSLSNGTYKQHISLEQVPSNPNSYFVKVKSSSFKDVYLPVASISEERKNDKILYKITAKVEKLQQEIESRYKDNFTFYLAKKGTEETTNFTSFSNLVKAINQNPSGTYHLAASLNANEVELGPDERSYIKDTFTGRLIGEKDGKNYAIYNLKKPLFENLSGATVEKLSLKNVAISGKDDIGSLANEAQNNTKIKQVHVDGVLAGERGIGGLLAKAEQSSITESSFKGRIINTYETTAAYNIGGMVGHLTGDKALLTKSKATVAISSNTNTSDQTVGGLAGLVDRDAQIQDSYAEGDINNVKHFGRVAGVAGNLWDRTSGDVRHAGSLTNVLSDVNVTNGNAITGYHYNEMKVKDTFSSKANRVYNVTLVKDEVVSKESFEERGTMLDASQIASKKAEINPLILPTVEPLSTSGKKDSDFSKVAYYQAKRNLTYKNIEKLLPFYNKATIVKYGNLVNENSLLYQKELLSAVMMKDNQVITDIVSNKQTANKLLLHYKDDLSEKLDLKYQNDFAKLAEYSLGNTGLLYTPNQFLYDQTSIIKQVLPDLQKVDYHSEAIRKTLGISPNVKQTELYLEDQFAKTKQQLEDSLKKLLSADAGLASANPVTEGYLVDKIKRNKEALLLGLTYLERWYNFSYGQVNVKDLVLYHLDFFGKGNASPLDTLIELGKSGFNNLLAKNNVDTYGISLASQHGTTDLFSTLEHYRKVFLPNTSNNDWFKSETKAYIVEEKSTIEEVKTKQGLAGTKYSIGVYDRITSATWKYRNMVLPLLTLPERSVFVISTMSSLGFGAYDRYRSSDHKAGKALNDFVEENARETAKRQRDHYDYWYRILDDNAREKLYRNILLYDAYKFGDDNTVGKATEVADFDNPNPAMQHFFGPVGNKVGHNQHGAYATGDAVYYMGYRMLDKDGAITYTHEMTHDSDQDIYLGGYGRRSGLGPEFFAKGLLQAPDHPDDATITINSILKHSKSDSTESRRLQVLDPTTRFNNADDLKQYVHNMFDVVYMLEYLEGNSILKLDTNQKQQLLRKVTNEYHPDPDGNKVYATNVVRNLTVEEVERLRSFNDLIDNNILSSREYASGKYERNGYFTIKLFAPIYAALSNDIGTPGDLMGRRIAYELLAAKGFKDGMVPYISNQYEEEAKQKGKTINLYGKTRGLVTDDLVLEKVFNNQYHTWSEFKKAMYQERQDQFDRLNKVTFNDTTQPWQTFAKKTTSSVDELQKLMDVAVRKDAEHNYYHWNNYNPDIDSEVHKLKRAIFKAYLDQTNDFRSSIFENKK
What is the function of this protein?
Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region, rendering it less efficient in coating the surface of colonizing or invading pneumococci.  Strongly contributes to virulence in mice.  May be responsible for pneumococcal infection and is potentially involved in distinct stages of pneumococcal disease.
What are the official names of this protein?
Immunoglobulin A1 protease, IgA1 protease, IgA-specific zinc metalloproteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M26 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Multi-pass membrane protein. Secreted, cell wall; Peptidoglycan-anchor.
Protein: DEOC_SYNP6
Sequence: MAELSSDFDLAPYIEHSLLDPAATLEQIDQLCQEADRYHFAAVCLFPWVVRQAREWLNGRSPRLCTVIDFPNGASTAASKVYAAQEAVENGAQELNVVVNLGWLRSDRADLVHQELAEIVEATGVPIKAILEATRLNPSELEQLTDLCLDAGVTMLQTSTGWFGGATPALVQQLRQLTRNRVGIHAAGGIRTWDQAAALVEAGAIRLGTSYGPMILQQRLAASTPAPA
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALLA_BRUAB
Sequence: MQIETLTVEPLTKEAFAPFGDVIEVEGAQLRLINNGTTERYHDLARMEAAGTQTRVLINIFRGQSFAAPIDIMMMERHPFGSQAFIPLNGRPFLVVVAEDAGAGPARPRAFLARGDQGVNYLRNIWHHPLLALEQKSDFLVVDRAGREDNLEEYFFSDYAYRIETTQTA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: C71A8_MENPI
Sequence: MYSIAFMLVLRKMDEIISHTLAFQALVSLILLISITKWLSNSPKNKNSSPPSPRKLPILGNLLQLGSLPHHNLRSMARKHGPIMLLHLGSVRPVSSRRRPRGNHENSRSRLRRPRGSRSAALQLQGRVGGYGEYWRQLKTICVVQLLSNKRVQSFRSVREEETELLMKKIGDSSGNVNLSHMFTQLTNDVVCRSAIGRKYGAGDENGEKFLEILREFLELLGAISIGDFVPSLWWINRINGFDRRVDRIAKEMDEFLEKVIHERLENPAAKAEENFVDILLEIYRNNSAGVSIDRDSIKAIILDVFAAGTDTTAVVLEWAMTELLRHPEIMKKLQSEVRQVVKDKHNITDDDIEKMHYLKAVMKETMRFHTPIPLLVPRVARNDVEVMGYDVPVGTMVMINAWAIGRDPTSWDEPEKFRPERFLNSSVDFKGLDFELIPFGAGRRGCPGTTFPMATLEFTLANLMQKFDWELPHECRELDMSERPGVAIRRVIPLLAIGTKM
What are the official names of this protein?
Cytochrome P450 71A8.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MRAZ_RHILW
Sequence: MSRFLSNATNRIDAKGRVSVPSAFRSVLVQRNVQELYCFQDFVFPAISVGGPDLLERFERQIAAEDPFSPDANEMSLLIHGGGVFMKLDAEGRLMVTDFIRGFTGISDEVTFVGRADHFQLWQPQAFVAAQAQARGERKLAGKRS
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ZC4H2_DANRE
Sequence: MADEQEIMCKLENIKEIRNKTIQMEKIKSRLRTEFEALESEEKHLREYKQEMDLLLQEKMAHVEELRLIHADINVMENTIKQSESDLNKLLESTRRLHDEYKPLKEHVDALRMTLGLQRLPDLSQEEEKLSLDYFEKQKAEWQTEPQEPPIPESLAAAAAAAQQLQAARKQDARQTATFRQQPPPMKACLSCHQQIHRNAPICPLCKAKSRSRNPKKPKRKPDE
What is the function of this protein?
Plays a role in GABAergic and V2 interneurons differentiation (PubMed:26056227).  Involved in motoneuron development and in neuromuscular junction formation (PubMed:23623388).
What are the official names of this protein?
Zinc finger C4H2 domain-containing protein, Hepatocellular carcinoma-associated antigen 127 homolog, Hepatocellular carcinoma-associated antigen 127-like.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Postsynaptic cell membrane.
Protein: Y3630_MAGSA
Sequence: MPSFDVVSKTDLAEVDNALAGITREVAQRFDFKGSKCSVERKDQMITVLADDDSKLKTMHELLSVHFTRRKVDPKALDYKTVEKASGNTVRQEVRIKDGVETVLAKRLVKEIKDAKLKVQVAIQGDELRVTGKKRDDLQEAIALLRKLDVDQPLQYINFRD
What are the official names of this protein?
UPF0234 protein amb3630.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: ORAI2_HUMAN
Sequence: MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL
What is the function of this protein?
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
What are the official names of this protein?
Protein orai-2, CAP-binding protein complex-interacting protein 2, Transmembrane protein 142B.
What is the protein family that this protein belongs to?
Belongs to the Orai family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MTC6_YEAS1
Sequence: MWILIYLFIIWSSLRTWVTAVDSTTTVGDDLNETVSTSVWPTMSPQMTVAFRSQRDVMGNLTIDQLPYVGLNLRRVLLNNETSMVNEGNNTRLLTLFKSMLSSEANAFVLDLEQYNNDLRVVDTTLLFSDVLIALQSFIFSTQNNLYANIIVLLLNISAPELDSTEYRHQNQTLNTTYILDKNLGNSFIYKPTDLQSDRAKNNTWNIYGKSSIDGWPTLGSVLYEQKKRLVIGELTDFFNETTAPYIFPHDVFHYEQGNSTLDCPSTVEGLTDLSSIHWRFLDSLFNSVDIKEYISCGLSPIISNSAYVNNVTQLADIIHEGSVWSWDSDQPSVTQSTSKSGSSSGTLEAYNCVLLYYFANNETVTWRVGNCYNSNIGLCRYENMAFRWLVRSNKATYFDFDSYQGSKCPDQYSFNIPRSPLEQRSFIAYMRNSSFSDTQIWIDLNSISVSNCWVSGGPYASCPYEKVISRRNFVTMMVPASVCSFALLCIVVYLSVLRVPIYDNRKNWRRVINKISKSELEGVPS
What is the function of this protein?
May be involved in telomere capping.
What are the official names of this protein?
Maintenance of telomere capping protein 6.
What is the protein family that this protein belongs to?
Belongs to the MTC6 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MAIA_NOCFA
Sequence: MGIRRIGLVVPSSNVTVETEMPALLSRHPGAEFSFHSTRMRMHTVSPEGLAAMNAQRERCVLEIADAAPEVILYACLVAVMVGGPGEHHRVESAVAEQLATGGSQALVRSSAGALVEGLRALDAQRVALVTPYMRPLAEKVVAYLEAEGFTISDWRALEVADNTEVGCIPGEQVMAAARSLDLSEVDALVISCCVQMPSLPLVETAEREFGIPVLSAATAGAYSILRSLDLPVAVPGAGRLLRQDSAVTAS
What is the function of this protein?
Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.  Shows a strict specificity for maleate, with no activity detected toward structurally related substrates including citraconate, mesaconate, dimethylmaleate, and maleamide.
What are the official names of this protein?
Maleate isomerase, MI, Maleate cis-trans isomerase.
What is the protein family that this protein belongs to?
Belongs to the maleate isomerase family.
Protein: YR7J_ECOLX
Sequence: MVTVGYVAITRAGISTFPTGIIKIRISLKKKFANLQKKPSEQRLSAPALMKRWRCCRWGMWCIAIRLMTVRFPAITLTASLKMTSITWHLFLNIDHQKVIQSLFLTVTHP
What are the official names of this protein?
Protein ORFj in retron Ec67.
Protein: MRD1_EMENI
Sequence: MESTRVFVSGLPPTLTNDQLKKHFETRFHVTDAHVLPKRRIGFVGFKSSEAAQQAVSYFNKTYMRMSKISVDIAKPIDAEPAHRKDSRTAQPDDALGNNLKRKRDGDTIKDSKTQEYLSLLQQPSKTRTWANDDQLPDPDETDSHAQEQEQPFDVDDQEELTYAQRKKAKLGQDANESSHVPVVAGYQPTTDESDGQPSPEKHEEELEDPQKDQAPVSDSDWLRSKTSRLLGLLDEDEQETFASPAAATNPTPIINSNVEKPEAESPEKPAESDLTKAPTAAEVDTNIENIRISARLFVRNLSYETKESELEPVFSPFGKIEEIHVAFDTRFTTSKGFAYVQYADPDAAVEAYRNLDGKIFQGRLLHILPASQKKTYKLDEHELSKLPLKKQKQIKRKQEAASSTFSWNSLYMNADAVMSSVAERIGVSKADLLDPTSSDAAVKQAHAETHVIQETKAYFKANGVNLDAFKQRERGNLAILVKNFSYGTKTEDLRKLFEPFGQITRLLMPPSGTIAIVAFARPDEAQKAFKSLAYRKLGDSILFLEKAPKDLFEADVPPQNPLPETKAVSQGFSTADTFAADEGDEEVMATATLFIKNLNFSTTNQSLIEAFRPLDGFVSARIKTKPDPKNPGQTLSMGFGFADFKTKAQAQAALAVMNGYTLDRHTLVVRASHKGMDAAEERRKEDTAKKIAARRTKIIIKNLPFQATKKDVRSLFGAYGQLRSVRVPKKFDRSARGFGFADFVSAREAENAMDALKNTHLLGRRLVLEFANEEAIDAEEEIQRIEKKVGEQLDRVKLQKLTGAGRKKFTVGAQDDES
What is the function of this protein?
Involved in pre-rRNA processing.
What are the official names of this protein?
Multiple RNA-binding domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the RRM MRD1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: 2A5K_ORYSJ
Sequence: MWKGFLSKLPRKTSASGRGADLDSGQCSNGAGNGNPIQRTSSCGSIPSGRSTSTIKRMSSAIFPSSVVAGIEPLVSFKDVPNSEKQNLFVSKLNLCCAVFDFSDPNKSSAEKDIKRQTLLDLIDYVDSSSSRFSEAVIAASSRMFAVNLFRVFPPNYRSSSSGGGEGEEEEPMFEPAWCHLQLVYELLLKFIGSSSLDAKVGKKYFDHSFIVKLLNLLDSEDPRERDCLKTILHRIYGKFMVHRPFIRKAVSNIFYHFVFETDRHNGIAELLEVFGSVISGFALPLKEEHKIFLWRVLVPLHKPKSVGVYLQQLTYCVTQFIEKDPKLASSVIIGLLRYWPITNSQKEVMFLSEIEEILETISTAEFQKCMVPLFRRIAQCIKSSHFQVAERALFIWNNDNVISLIAQNRQMIMPIIVPALEHNSQNHWNQAVLNLTDNVKKMFSEMDDVLFSACLVKYKEDEERQASLESKRRLTWEKLESAASFQPVTGHTAVLVGRQPSANLIATLI
What is the function of this protein?
B regulatory subunit of phosphatase 2A (PP2A) involved in salt stress response (PubMed:31221736).  Under salt stress conditions, required for the catalytic activity of PP2A and the dephosphorylation of SIT1, a negative regulator of salt tolerance (PubMed:31221736).  Dephosphorylation of SIT1 turns off salt-induced SIT1 activity directly, which has a positive effect on salt tolerance (PubMed:31221736).
What are the official names of this protein?
Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform, OsB'kappa, PP2A, B' subunit, kappa isoform.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B56 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=The partial localization to the plasma membrane may be due to its association with SIT1.
Protein: ATPE_SYNFM
Sequence: MAEKIKLEIVTPEKKVLSEMVDIVVAPGQEGEFGVLPHHIPFLSKLKVGELRYRIGQTLRCVAIMGGYAEVLPDQVTILAPAAEEAGEIDVIRAKAARERAERRLAETKDRLEFTRAQAALQRAVARLKVAEKT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: O13J1_HUMAN
Sequence: MEPLNRTEVSEFFLKGFSGYPALEHLLFPLCSAMYLVTLLGNTAIMAVSVLDIHLHTPVYFFLGNLSTLDICYTPTFVPLMLVHLLSSRKTISFAVCAIQMCLSLSTGSTECLLLAITAYDRYLAICQPLRYHVLMSHRLCVLLMGAAWVLCLLKSVTEMVISMRLPFCGHHVVSHFTCKILAVLKLACGNTSVSEDFLLAGSILLLPVPLAFICLSYLLILATILRVPSAARCCKAFSTCLAHLAVVLLFYGTIIFMYLKPKSKEAHISDEVFTVLYAMVTTMLNPTIYSLRNKEVKEAARKVWGRSRASR
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 13J1, Olfactory receptor OR9-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APT_BRUA2
Sequence: MESGFKVTLKDAIRTIPDYPKPGVQFRDVTTLMGNAQAFRRAVDELVYPYAGNRIDKVAGIEARGFILGGAIAHQLSAGFVPIRKKGKLPRDTVRIAYSLEYGVDEMEMHRDAIEKGERVVLVDDLIATGGTAEAAAKLLLQMGAEIVAACFIIDLPDLGGRKKLEALGLPVRTLVAFEGD
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPH_ECOLC
Sequence: MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMAQASRKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: CNSH_PENEN
Sequence: MWVNTLRCPEGIEKVFPGPFACYNRLFDPGSQLDSYALIEETLHTYGPFDGAFGFSQGAALIVSYLLERRAAYPDESLPFRFLILCSPVVPLAGNAEYCHRILGCLSRDNESRIRSCQDTQISDLPERARIAMTMLTDILDASTTITQEPRRFYLDRELPDVPCALHPDLCLTRLPVATLHVRGTTDAKALWNCGFLIQSFFDSPKLRVFEHKSGHDIPRSGPEVRQMLCAMEWIIAQSELP
What is the function of this protein?
Serine hydrolase; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals (PubMed:25571861).  Communesins are biosynthesized by the coupling of tryptamine and aurantioclavine, two building blocks derived from L-tryptophan (PubMed:25571861).  The L-tryptophan decarboxylase cnsB converts L-tryptophan to tryptamine, whereas the tryptophan dimethylallyltransferase cnsF converts L-tryptophan to 4-dimethylallyl tryptophan which is further transformed to aurantioclavine by the aurantioclavine synthase cnsA, probably aided by the catalase cnsD (PubMed:25571861).  The cytochrome P450 monooxygenase cnsC catalyzes the heterodimeric coupling between the two different indole moieties, tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacyclic communesin scaffold (PubMed:26963294).  The O-methyltransferase cnsE then methylates the communesin scaffold to produce communesin K, the simplest characterized communesin that contains the heptacyclic core (PubMed:25571861).  The dioxygenase cnsJ converts communesin K into communesin I (PubMed:25571861).  Acylation to introduce the hexadienyl group at position N16 of communesin I by the acyltransferase cnsK leads to the production of communesin B.  The hexadienyl group is produced by the highly reducing polyketide synthase cnsI, before being hydrolytically removed from cnsI by the serine hydrolase cnsH, converted into hexadienyl-CoA by the CoA ligase cnsG, and then transferred to communesin I by cnsK (PubMed:25571861).  Surprisingly, cnsK may also be a promiscuous acyltransferase that can tolerate a range of acyl groups, including acetyl-, propionyl-, and butyryl-CoA, which lead to communesins A, G and H respectively (PubMed:25571861).  The roles of the alpha-ketoglutarate-dependent dioxygenases cnsM and cnsP have still to be determined (PubMed:25571861).
What are the official names of this protein?
Serine hydrolase cnsH, Communesin biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase 3 family.
Protein: YL018_MIMIV
Sequence: MNKNCDYCGLTIYSETYHKCVESSVKINDETKIVNYKIITIDELGILAGKNDREAQDEIVYRYLNQDAINLSQKNIKPINWENIIERAIDDQYFTYFLLFFAFDHDEYHVIFDVLFDVLFENVKLAAKTGDSMAQYNLGQMYYRGISTKKNIQKAIKWITKSADQNNKYGLINLARFYEYGDGVLLDIDKATQLLEQASCQNFSKAQFYLGRIYMYKDPPDYKLAFKYYQQAANQNHSSAQYFIAVFYKTGKCVAQDYKKAVHWLTLAASQGLNSAKIKLAEMYMKGIDVEQNYHKAFELLNSSIYDDGTNNYYDEVAMTELACMYKRGLGIEKNISKAIYLHIKSRNTKNIFKIFEINTITFINPINVDCENNNLSDIDQLESKIIYKLQFLMIKLKYEWSNIYHDDISNSLQEIENSFTRLIKLRIQLNNSSAMINCLSFKKNTSYKFDVFNTKNAYVNYYVYDDISYINIGLNNIKLVNNFQKNLDKFMFCNIFLDLELALENKHKEKIDDLINAVKNDDRSHQLNIVKDLDNIKFVLSQTKKISSKLIGYVNILMNDLKSNTHIRNQQFQLEYANIFGYD
What are the official names of this protein?
Putative sel1-like repeat-containing protein L18.
Protein: DIAA_ECOLU
Sequence: MQERIKACFTESIQTQIAAAEALPDAISRAAMTLVQSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDV
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: CRK30_ARATH
Sequence: MRQNNLFSLIFWLVPVSLIIVVSAQLCSEKFGTFTPGGTFDKNRRIILSSLPSEVTAQDGFYNASIGTDPDQLYAMGMCIPGAKQKLCRDCIMDVTRQLIQTCPNQTAAIHWSGGGKTVCMARYYNQPSSRPLDLESVSIGYNVGNLSTNLTDFDRLWERLIAHMVTKASSASIKYLSFDNSRFYAADETNLTNSQMVYALMQCTPDVSPSNCNTCLKQSVDDYVGCCHGKQGGYVYRPSCIFRWDLYPFNGAFDLLTLAPPPSSQLQSPPPVTNKDEKTIHTGTIIGIVIVVAMVIIMALLALGVSVCRSRKKYQAFASETADDITTVGYLQFDIKDIEAATSNFLASNKIGQGGFGEVYKGTLSNGTEVAVKRLSRTSDQGELEFKNEVLLVAKLQHRNLVRLLGFALQGEEKILVFEFVPNKSLDYFLFGSTNPTKKGQLDWTRRYNIIGGITRGLLYLHQDSRLTIIHRDIKASNILLDADMNPKIADFGMARNFRDHQTEDSTGRVVGTFGYMPPEYVAHGQFSTKSDVYSFGVLILEIVSGRKNSSFYQMDGSVCNLVTYVWRLWNTDSSLELVDPAISGSYEKDEVTRCIHIGLLCVQENPVNRPALSTIFQMLTNSSITLNVPQPPGFFFRNRPESDTLRRGLEPDQYNNESVTCSIDNATITTLLGKTLASALCCITSTLFSKSMYRNTED
What are the official names of this protein?
Putative cysteine-rich receptor-like protein kinase 30, Cysteine-rich RLK30.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SRG7_CAEEL
Sequence: MASSPPIYNLEQYGTNCSEEYSNFYENSKYWIQCLWLIPTLFLLVWIIITTRVRYPSQYSNLPYWILTADCVVSIILILLDLFVVRLFLYFPQLCSKFSTIFINYPIISDIYFPIYNYARVFKTGSQCGMILSRLFCVLIPFGHDEKLRRHIPLFLTIICILPILVVWNTVISEKEVVFWYGGFFVIYHRRVGWVSLSKLHLTFIFVSISFILISSLLLMRHLPIESAVNAERRVITNSIFIIVAFFFQAAFQSFYAFFRYTDWYPRFLVDFQFIIYDVMTVGYPLIFLNFAKEFRNHVFLKSNRKGRTLMELRSMSKPFNNTMPRQESPSPNYDSILA
What are the official names of this protein?
Serpentine receptor class gamma-7, Protein srg-7.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein srg family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL15_STAAN
Sequence: MKLHELKPAEGSRKERNRVGRGVATGNGKTSGRGHKGQKARSGGGVRPGFEGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESGVVKNEKSGIKILGNGSLDKKLTVKAHKFSASAAEAIDAKGGAHEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: SYL_YERPG
Sequence: MQEQYRPEDIETQVQLHWQEKQTFKVTEDASKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVISRYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIEYMKNQLKLLGFGYDWDREIATCKPDYYRWEQWFFTKLYEKGMVYKKTSAVNWCPHDLTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITDYAEQLLNDLDTLESWPEQVKTMQRNWIGRSEGVDIVFDVVDSEEKLSVYTTRPDTFMGVTYVAVAAGHPLSLQAAATNPALADFVAECRNTKVAEAEMATMEKKGMATGLYAIHPLTGEKLPIWAANFVLMDYGTGAVMAVPGHDARDWEFATKYNLPIKPVILAADGSEPDLSQEAMTEKGTLFNSGEFDGLNHEDGFNAIADKLVALGVGQRKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVVPTPEDQLPVILPEDVVMDGISSPIKADPEWAKTTVNGIPGLRETDTFDTFMESSWYYARYTCPQYDDGMLDPAAANYWLPVDQYVGGIEHAIMHLMYFRFFHKLLRDAGLVDSDEPAKRLLCQGMVLADAFYYTGNNGERIWVSPVDAIVERDDKGRIVKAVDAEGHELVYAGMSKMSKSKNNGIDPQVMVEKYGADTVRLFMMFASPAEMTLEWQESGVEGANRFLKRVWRLAFDHTAKGAVKPLDIASLTEEQKSLRRDLHKTIAKVTDDVGRRQTFNTAIAAVMELMNKLGRAPQETEQDRALMQEALLAVVRMLYPFTPHVCFSLWQALGGEGDIDTAPWPIADEQAMVEDSKLVVVQVNGKVRGRITVPADATEQQVRERAGQEHLVAKYLDGITVRKVIYVPGKLLNLVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLB2_MORMR
Sequence: MPIVDSGSVSPLSDAEKNKIRAAWDIVYKNYEKNGVDILVKFFTGTPAAQAFFPKFKGLTTADALKKSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLQELSVKHAQSFYVDRQYFKVLAGIIADTTAPGDAGFEKLMSMICILLSSAY
What are the official names of this protein?
Globin-2, Hemoglobin II.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: HEMA_INBSJ
Sequence: IVLLMVVTSNADRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTQTRGKLCPNCLNCTDLDVALGRPKCMGTIPSAKASILHEVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSARNVINAETAPGGPYIVGTSGSCPNVTNGKGFFATMAWAVPKNKNKTARNPLTVEVPYICTKGEDQITVWGFHSDNEIQMVTLYGDSKPQKFTSSANGVTTHYVSQIGGFPNQTEDEGLQQSGRIVVDYMVQKPGKTGTIVYQRGVLLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKERGFFGAIAG
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.