PharMolix/UniProtQA huggingface dataset:
Protein: RLME_STUS1
Sequence: MKRSKSSRRWLDEHVNDPFVKRAQKDGLRSRSSYKLIELNEKDKLIRPGMLVMDLGSAPGGWSQVAGGIVGEKGRVLATDILPMGGLDNVDFVQGDFTEDAVFQQILDMLDGRQPDLIVSDIAPNISGVAAADQAASMYLVELTLDMVRQVLKPGGNYVVKVFQGEGSDEFLKDVRSSFEKVVIRKPEASRPRSREVYLVAKGFKG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
Protein: MURC_ALKMQ
Sequence: MIAFNMDEHQLKHIHLIGIGGISMSAIAEILLENGYHISGSDMKESNLTHKLRDHGAEIFIGHASENIQNPDLVVYTAAVKADNPERIRAEELGIPLADRAEMLGQIMKKYEKAIAVAGSHGKTTTTSLISLLMEYSNLDPTILVGGELDEIGGNIKIGQSQHFITEACEYVESFLKFYPFIGIILNIDEDHLDYFKDIEHIKSAFKKFAQRIPKEGFLIASYDDAHVREISRDLDCHVITYGIKTKSQFMAHNIEFSFEGLPSFDVSFEGKTIGSFSLNIPGLHNVYNSLAAIATTYVLGVDPVAISKHITRFKGIHRRFDLLGEVKGAKVIDDYAHHPVEIRATLEAAKKYPHKKIWCVFQPHTYSRTQALLKDFAKSFYLADHVIITDIYAAREKDEGIVNSQGLVNLIVQEHPAQYIGGFEEISRYLYDHIEAGDIVLTMGAGDVYLIAQMLLAEK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S38AB_DANRE
Sequence: MESERSCLLSSHDAGKGGSSSVSSASFNFINSIIGSGIIGLPYSMSQAGLPMGLLLLILVAFITDYSIILLVRGGNLSGTHSYQSLVRSTFGQIGYIIVSVLQFLYPFIAMISYNIIAGDTLTKVFMRIPGVGPGNILTERHFVIAMSTVLFTLPLSLYRDIAKLGKVSLLSMILTFGILMTVVVRAATLGPQIPASDDAWVFARWNAIQAVAVMSFALICHHNSFMIYGSLQEPTLSRWSLVTHISVGSSVLVSAVFAAAGYATFTVYTQGDIFENYCRSDNLATFGRFCYGVSIITTFPLECFVTREVISNALFKGGELSKSSHVIITLVIISATTAISLSYDCLGIVLELNGILSAVPLMFIFPSACFLKLSNERWCRGENLIASMILVAGVFVMIIGLIMMALFPQDCSHGAEMFYCSASNTSSTASPSNILQFINTTQNTSIV
What is the function of this protein?
Putative sodium-dependent amino acid/proton antiporter.
What are the official names of this protein?
Putative sodium-coupled neutral amino acid transporter 11, Solute carrier family 38 member 11.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DHKD_DICDI
Sequence: MQDISTTTASTNYLKADGDTGAVFSITSQQQQIHYMRKQKPDHEKTREELIEEINHLRAVSNSNKNARIMLDEMYQFVALLDVNGNLLDVNEPALQGGGMIRSSIQGIPFWDCRWWATSQENIDNVREAVHKASKGEFIRYETEIFGKSAGTEKITIDFSLMPLFNDKGEVSLILPEGRNITEKRLGELEIERKNNELRSLYEKIKELDELKTQFFANVSHELRTPLALIVGPTDKLLKDENVDINVRKDLEIVARNARGLLKIVNNLLDISRLEAGKMNLNYSMVNLGQTVHLIASCFEILAREKSLDFSIITPSEPMMAAIDADKMQRVITNLISNAFKFTPSGGAVKCILEKFDLSPNKPGFQIVVSDTGPGIPDNLHEIIFERFRQVDGSSTRKHGGTGLGLSIVKEFVTLHGGTVTIHNISTGGAQFTLRLPLTPNMDEHLYKKTISDQNISEIQQQLYQQQQQEQQQQQQQQQNLQQPKLILNNIDNKYKINDDDNDDDDDDDDEDGLNFNILKKTNTSSDIASNALKDNMGSIMGVHAIAQQAVEELTEKQFYQSQENIHNKPIVLVVEDNPEMNRFIAELLSKYYFVVTAFDGVEGIEKTRAITPDLIVTDCMMPRMSGDEMVEQLRSDEQFDNIPILLLTAKADENLRIKLLQNGVSDYVNKPFSSEELVARVVNLMTMKKAKQFLQEELSSANTDLQELINQLTNKKRDLQTLVGELEKERNLLNNTNKSKDEFFMNLSHELRTPLNGILGWCQLLLYDIDSGGSSGGGSGSISGDDSTVRTGLETIERCASSQNQLINDLLDMSLIIGDKFSLILGDVDLPILIENAISSILVTAQSKKISVHSNIQGEGEEESSILRNIVGDKARLQQVIWNLLSNSIKFTKEKGRIHLNLKVVNQIPSREVLGFCSNPMFNTINRHGDRWILFTITDNGKGIPKQFLPSVFDRFKQADCSSTRSYGGLGIGLSITQNIIHLHKGAVYANSEGENKGSQFTVVLPIIKGSSSSNSSPSNQLSCSSSPPLIKKPFFSQPTNYINNNNNNNNNNNNNNNNNNNNNNNNNNNNNYNNYNNNNSNNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNLNINNLINNNHNNNNNNYHHNNNNNNNSNNNEKLGKRQREEINNNENNNVDLRLRTPPPPPTSSISENFLVNSSNLIPSPALNPINNNNNSNNNNNNIGDIKKINLEISQIPSTNLNPKLSLVINNNNNNNNNNNSLLKTIITNAINNNINNSNNDDNSNNTTIPTPPSSAINMINSLPLPSPSPSFILPTLSPFSSPLSELKSSSNNNNNNNNNSNNNNNNSMSPNLRSPKANSNKNLLGGIQIMLVDDLEETTHLFSSMLYKLGAKRIDTFQRVSDAYAFLCDSSKPQPDIILSDLTMPFEDGYSMVRKLRDREKINTQNKKTPIIALTASVSSSDKEKVLKSGFDLHCSKPVNFLELSNSILTLIEKYNTTVNIDLIKEQEQNNNNNNNNNNNNNNNNNNNNNNINNGNDDDSLLLTDSRPCKKANSQ
What is the function of this protein?
Acts as a receptor histidine kinase for a signal transduction pathway.  This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity).
What are the official names of this protein?
Hybrid signal transduction histidine kinase D.
Protein: RK12_PORPU
Sequence: MSTKVENILEELKSLNLLEAAELVKQIEETFDVDASAASGGVMMAAPSSAPAASDVEEKTEFDVVLEEVPAPKKIAVLKVVRSLTGLGLKEAKDLVESAPKTLKEGASKDDAEAMKKQLEDAGATVGVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FMAC_ASPFU
Sequence: MNREDVEFPTCDGLILRGWLYPGTIRGPAIVMNQGFNTPKEILLPDVAVWFQQQGVTVLLYDNRCIGASDGEPRNDVKPAKLVEDFHDALTFMARHPMVDEDKIILYGYSFSAMTALVAAGLDHRVGAAISVTPIANYDFREKEKNNVMALAMQDRVSTLAGNDPVYIPFVGDDGYNPAGWGNQYNMEQFRAFLGTSFFTNRTTVQSYYHVLAWQPYGAMRLIKGTPVMMVTPAEDTISSPADQRAVFDMIPEPNKEFDLVAGRGHMDVINGEGAEEVLQRQLAFMRKHLDF
What is the function of this protein?
Polyketide transferase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:23488861, PubMed:24568283).  Within the pathway, the polyketide transferase af380 catalyzes the transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene to produce prefumagillin (PubMed:23488861).  The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520.  The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps.  5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene.  The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin.  Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (PubMed:24568283) (Probable).
What are the official names of this protein?
Polyketide transferase af380, Fumagillin biosynthesis acyltransferase, Fma-AT.
What is the protein family that this protein belongs to?
Belongs to the polyketide transferase af380 family.
Protein: DCD_WIGBR
Sequence: MRLCDRDIEIWLKKNKLIITPRPSKDRINGATVDLKLWNKFRIFESYNAAYIDFDLISSLKNNNSNSWNYNMTNEIKISEKEKFFLHPGELVLALTLESITIPDNLIGWLDGRSSLARFGLMVHATSHRIDPGWSGNIVLEFYNSGKLPILLRPNMIIGSISFELLTNSAIRPYNKKKNAKYLNQIDTVIKINNLT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: LIPA2_HUMAN
Sequence: MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPSGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTTSGQSRKMTTDVASSRLQRLDNSTVRTYSC
What is the function of this protein?
Alters PTPRF cellular localization and induces PTPRF clustering.  May regulate the disassembly of focal adhesions.  May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.  In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165).
What are the official names of this protein?
Liprin-alpha-2, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2, PTPRF-interacting protein alpha-2.
What is the protein family that this protein belongs to?
Belongs to the liprin family. Liprin-alpha subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell surface. Cell projection, dendritic spine. Note=Colocalizes with PTPRF at the cell surface.
Protein: TXM4E_DINQU
Sequence: MKLSAFTLAFALILMMAIMYNMAEAAALADADADAEAIAGLKDWWNKHKDKIVKVVKEMGKAGINAAGK
What is the function of this protein?
May have antimicrobial properties, like most ant linear peptides (Probable).  In addition, when tested in vitro on the parasite Trypanosoma cruzi (responsible of the Chagas disease), is able to moderately reduce the number of the three forms (epimastigote, trypomastigote and amastigote) by inducing cell death through necrosis (PubMed:28976889).
What are the official names of this protein?
M-poneratoxin-Dq4e, M-PONTX-Dq4e, Peptide sDq-3348, U-poneritoxin(01)-Dq7a, PONTX(01)-Dq7 (contig 1), U-PONTX(01)-Dq7a, contig 9.
What are the subcellular locations of this protein?
Secreted.
Protein: SECB_BURP1
Sequence: MSDVENQPFFNIQRIYLKDLSLEQPNSPAIFLEQEMPAVEVEVDVKAERLAENVYEIVVAGTVTAKVREKVAFLVEAKQAGIFDIRNIPAEQIDPLCGIACPTILFPYLRSNIADSITRAGFPPIHLAEINFQALYEQRLAEISQQQQQGGAPNGTTLN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTGA_RHIME
Sequence: MPAGRWTATRRTWRSRRRRLVFIVLSVLILPYALIGLYLLEFIHPVSTLMLRDLVLLRGYDRQWVEFDDIAPVLVQSVMMSEDGQFCAHAGIDWAQMRGVVEDALDGEQTRGASTIPMQTVKNLFLWNGRSFVRKAMELPLAIAADFAWSKRRLMEIYLNVAEWGEGIYGIEAAARHHFGVSAAKLSRRQAALLAVSLPNPIDRTAGKPGRGLRRLAAVIERRAGRSGGYITCLYD
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: GAL1_THEP1
Sequence: MKVKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSDRFIFHSENVNETVEMEKIEKLNKWTDYISGVIASFEKRGYRVSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKDHAIFLDTMTLEYEYVPLRLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKSFREVTKEDLERLSGTLRKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKEGILGARMVGGGFGGGVIVLSKKGAFGKIKEELVESYKKHFGIDLTFHEIESSDGVQKI
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_HYPNA
Sequence: MKAPYFWSADLDPKSREAAPLTRLLLTPFAMLYLWALRRKLAKARPEAAPVPVVCIGNLTAGGAGKTPVTEAIRNRIRSAGLRAASLSRGHGGAEPGPLKVDPARHTSRDVGDEPLLLAGSGEAWIGRKRPEAARAMAADGAEIILMDDGHQNPSLKKDLTLIVIDAGAPFGNGHVLPKGPLREKVPEGLARADAVILMGAGPVPPEVTASSLPVLRARLAPLAAPPPGPLVAFAGIGRPQKFFDSLAQAGGNVSDAVPFGDHHPYTKGDVQFLRSLAHDHGARLITTTKDHVRLPLDAQSEILAWPVTAVFEDTAALDAVLAPIFKRAGKP
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: DCBD2_MOUSE
Sequence: MASRAPLRAARSPQGPGGPAAPAATGRAALPSAGCCPLPPGRNSSSRPRLLLLLLLLLQDAGGQQGDGCGHTVLGPESGTLTSINYPHTYPNSTVCEWEIRVRTGERIRIKFGDFDIEDSDYCHLNYLKIFNGIGVSRTEIGKYCGLGLQMNQSIESKGSEVTVLFMSGTHAAGRGFLASYSVIDKEDLITCLDTVSNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSPLCMAGIHAGVVSNVLGGQISIVISKGTPYYESSLANNVTSTVGYLSASLFTFKTSGCYGTLGMESGVIADPQITASSALEWTDHMGQENSWTAEKARLRKPGPPWAAFATDEHQWLQIDLNKEKKITGIVTTGSTMIEHSYYVSAYRVLYSDDGQRWTVYREPGVDQDKIFQGNKDYHKDVRNNFLPPIIARFIRVNPVQWQQKIAMKVELLGCQFTLKGRLPKLTPPPRNGNNLRNTTARPKLGKGRAPKFTQVLQPRSRNELPVQPAETTTTPDIKNTTVTPSVTKDVALAAVLVPVLVMALTTLILILVCAWHWRNRKKKTEGAYDLPHWDRAGWWKGMKQLLPAKSVDHEETPVRYSTSEVSHLSAREVTTVLQADSAEYAQPLVGGIVGTLHQRSTFKPEEGKEAGYADLDPYNSPMQEVYHAYAEPLPVTGPEYATPIVMDMSGHPTASVGLPSTSTFKTAGTQPHALVGTYNTLLSRTDSCSSGQAQYDTPKGGKSAATPEELVYQVPQSTQELSGAGRDEKFDAFKEIL
What are the official names of this protein?
Discoidin, CUB and LCCL domain-containing protein 2, Endothelial and smooth muscle cell-derived neuropilin-like protein.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: XRCC1_ARATH
Sequence: MSQKRNLPSWMSSRDPEITPSKSHCKKPKDEGPTEEHNSRNAPSNKSEHAEPSSNTTEFSKLMEGVVFVLSGFVNPERSTLRSQALTMGATYQPDWNAGSTLLICAFPNTPKFRQVETNGGTIISKEWITECYAQKKLVDIEQYLMHAGKPWRKSSSPQDANREKREHLSKKPEKQVEKKTETRGTPSTSSKNRSACNLVKEPFFVTEVKKWARDDLSQTISWLESQEEKPEPGEIKRIAAEGVLTCLQDAIDSLEQKQDIGSVTELWSFVPRVVKELGKMESSSKKENSTASKEEVCKQAKSWKKIYEAELAKPGEDESTSRVACGYDSDMTVEMTEEEIELAYRNVSLECL
What is the function of this protein?
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents (By similarity).  Involved in DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation.
What are the official names of this protein?
DNA-repair protein XRCC1, AtXRCC1, Homolog of X-ray repair cross complementing 1.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates at sites of DNA damage.
Protein: CHDC_STAAE
Sequence: MSQAAETLDGWYSLHLFYAVDWASLRIVPKDERDALVTEFQSFLENTATVRSSKSGDQAIYNITGQKADLLLWFLRPEMKSLNHIENEFNKLRIADFLIPTYSYVSVIELSNYLAGKSDEDPYENPHIKARLYPELPHSDYICFYPMNKRRNETYNWYMLTMEERQKLMYDHGMIGRKYAGKIKQFITGSVGFDDFEWGVTLFSDDVLQFKKIVYEMRFDETTARYGEFGSFFVGHIINTNEFDQFFAIS
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis (PubMed:26083961).  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway (PubMed:26083961, PubMed:27936663, PubMed:27982566).  The reaction occurs in a stepwise manner with a three-propionate harderoheme intermediate (PubMed:26083961, PubMed:27936663, PubMed:27982566).  The first decarboxylation step is fast and yields the three-propionate harderoheme isomer III intermediate, while the slower second decarboxylation appears to control the overall rate.  H(2)O(2) is the assumed biological oxidant, but either H(2)O(2) or peracetic acid yields the same intermediates and products (PubMed:26083961).  Has weak peroxidase and catalase activities in vitro (PubMed:23737523).
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: DABA_STAAB
Sequence: MTTQLNINLVIENAKRVITPLSPISIFAARNPWEGLEADTFEDVAKWLRDVRDVDIFPNKALIESAVARGELDESVFNQLVTDMLLEHHYNIPQHYINLYIDNIKTLKDVPASYMNHSNVDVVADLLLEKSKRDMAESYHHYDVRPMSDAIIDEQGEPLSEQVNRQMIKWTKLYIDQFLSSWTMPKREQSFYHAWLHLAQHDHSFTKAQRQVIKDLPNDPKMTIESVLNHFSIAQEDYQAYVEGHLLALPGWAGMLYYRSQQHHFEQHLLTDYLAIRLVVEQLLVGDEFKSVTKDCESRSENWFKQTVASWCYYSDMPSDVLLQHDVNEIQTFIHFAATMNKNVFKNLWLIAWEMTYESQVKQKIKAGHESLAGALDVNQVNVTENDNANQSHSVSLNDTQAVDENNSELNQVDTSTKAQIAFCIDVRSEPFRRHIEAAGPFETIGIAGFFGLPIQKDAVDEQFKHDSLPVMVPPAYRIKEFADRYDMNVYRQQQQTMSSMFYTFKLMKNNVMPSLLLPELSGPFLSLSTIVNTIMPRKSRASLQKIKQKWLKKPETKLTIDREFDRTSDLPVGFTEQEQIDFALQALKLMDLTEAFAPFVVLAGHASHSHNNPHHASLECGACGGASSGFNAKLLAMICNRPNVRQGLKQAGVYIPETTVFAAAEHHTSTDTLAWVYVPDTLSALALDAYESLNDVMPMISEHANRERLDKLPTIGRVNHPVEEAQRFASDWSEVRPEWGLAKNASFIIGRRQLTKGIDLEGRTFLHNYDWRKDKDGTLLNTIISGPVLVAQWINLQYYASTVAPHFYGSGNKATQTVTSGVGVMQGNASDLMYGLSWQSVMAADRTMYHSPIRLLVVIQAPDYVVARLLANNEHFARKASNHWLRLMSVNEEGRFKSWI
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MQNB_STRCO
Sequence: MHLLVATAVSVERDAVARAFPAPGTEVSRPGITLHRLPDGWDLLAAGVGPARAAASTAAALTAAALDGRPYDLVVSAGIGGGFAPEAPVGSLVVADAITAADLGAETADGFLPVTDLGFGTVTHLPPAPLVRAAAEATGARPGTVLTGSTVTGTAARAALLRERHPGALAEAMEGFGVAEAAAAHGVPVLELRAVSNPVGPRDRAAWRIGEALAALTDAVGKLAPVLESWKPHER
What is the function of this protein?
Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).  Does not accept aminodeoxyfutalosine (AFL) as a substrate.
What are the official names of this protein?
Futalosine hydrolase, FL hydrolase, Futalosine nucleosidase, Menaquinone biosynthetic enzyme MqnB.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
Protein: ZUP1_MOUSE
Sequence: MLSCNICGETVNSEPDMKAHLIVHMENEIICPFCKLSGINYNEICFHIETVHFEQNAPEKNSEKLAAVQYGHSDRKNTNLQSTAEVTSGIHSACASSFPKESSESLPKDRTVKHEAFYTENITESRKYQKSREKKPGLSEAQGSIYETTYSPPECPFCGKIEGCSQDMEIHVKTKHASLLESPLKDCHQPLYDCPMCGLVCTNYHILQEHVDLHLEESSFQQGMDRVQCSSDRELAHRLQQEEDRKRKSEESRQEREEFQKLQRQYGLDNSGGYKQQQLRHMELEVNRGRMHPSEFHSRKADMLESIAIGIDDGKTKTSGIIEALHRYYQNTATDVRCVWLSTVVDHFHSSFGDKGWGCGYRNFQMLLSSLLQSDVYGDCLKGMAVPCIPKIQSMIEDAWNEGFDPQGASQLNNKLQGTKAWIGACEIYTLLTSLRVKCRIIDFHKSTGPLGTHPRLFEWILNYYSSETEGTPKIVCTSKPPIYLQHQGHSRTVVGIEEKKNRTLCLLVFDPGCPSREMQKLLKQDMEASSLRQLRKSVGNLKHKQYQIVAVEGVLSPEEKVARKQASQVFTAEKIP
What is the function of this protein?
Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains.  Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains.  Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage.  Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.
What are the official names of this protein?
Zinc finger-containing ubiquitin peptidase 1, Lys-63-specific deubiquitinase ZUFSP, DUB, Zinc finger with UFM1-specific peptidase domain protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase C78 family. ZUFSP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mostly present in the nuclear fraction. Localizes to DNA lesions.
Protein: RL16_ECOL5
Sequence: MLQPKRTKFRKMHKGRNRGLAQGTDVSFGSFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLAVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RS4_DROME
Sequence: MARGPKKHLKRLAAPKAWMLDKLGGVFAPRPSTGPHKLRESLPLLIFLRNRLKYALNGAEVTKIVMQRLVKVDGKVRTDPTYPAGYMDVITLEKTGEFFRLVYDVKGRFVIHRISAEEAKYKLCKVKKTQLGAKGVPFLVTHDGRTIRYPDPLIHANDSVQVDIASGKITDYIKFDSGNLCMITGGRNLGRVGTVVNRERHPGSFDIVHIKDSQGHVFATRLTNVFIIGKGNKPYISLPKGKGVKLSIAEERDKRLAAKTH
What are the official names of this protein?
40S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: TRPD_SHEB5
Sequence: MSTNPIQPLLDVLYQGKSLSREQTAELFGALIRGEMSEAAMAGMLVALKMRGETIDEISGAADAMRAAAKPFPCPERNNNPLHNGIVDIVGTGGDGFNTINISTTAAFVAAAAGAKVAKHGNRSVSSKSGSSDLLAQFGIDLTMSPETASRCLDALNLCFLFAPHYHGGVKHAVPVRQALKTRTLFNVLGPLINPARPEFMLLGVYSPELVLPIAKVLKALGTKRAMVVHGSGLDEVALHGNTQVAELKDGDIIEYQLTPADLGVPLAQISDLEGGEPAQNALITEAILKGRGTEAHANAVAINAGCALYVCGITDSVKAGTLLALATIQSGKAFELLSQLAKVSGEALVNGQERGR
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: KPYK_CANAL
Sequence: MSHSSLSWLSNFNVETVPSKYLRRSSIIGTIGPKTNNVDVLVKLRKAGLNVVRMNFSHGSYEYHQSVIDNARKSEEVYKGRPLAIALDTKGPEIRTGTTIGDKDYPIPPNHEMIFTTDDAYKTKCDDKVMYIDYKNITKVIAPGKIIYVDDGVLSFEVISVDDEQTLKVRSLNAGKISSHKGVNLPGTDVDLPALSEKDIADIKFGVKNKVHMIFASFIRTANDVLEIRKVLGEEGKDIQIISKIENQQGVNNFDEILEVTDGVMVARGDLGIEIPAPQVFVVQKQLIAKCNLAAKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPVEAVSMMHNTCLTAEKAIAYPQLFNELRSLAKKPTATTETCAVAAVSAAYEQDAKAIVVLSTSGLSARLVSKYKPDVPILMVTRNERAAKFSHLYRGVYPFIYDKPSIENWQEDVENRLRWAVSEAVELGIISKGDSIVTVQGWTRGSGHSNTVRIVQA
What are the official names of this protein?
Pyruvate kinase, PK.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_PELPD
Sequence: MREQLEQLRCEAFQAIADASTGEALQNIRIKYLGRKGAMTALMKGLGALSAEERPVVGQMVNSIRDEIESGIEAGLFAARERARDEKLRSERIDVTLPGRRPGCGSKHPITLVIEEVCDIFAGLGFSVAEGPEIEHDWYNFEALNFPPEHPARDMQDTFFVDNNLLLRTHTSPVQIRTMLKRKPPLRIIAPGTVYRCDSDATHSPMFHQIEGLMVDQGVSFGDLKGILTIFTNQLFGQKTGVRLRPSFFPFTEPSAEVDIACVICGGKGCRVCKNSGWLEILGAGMVDPEVYRHVGYDAEAVSGFAFGMGIERIAMLKYGISDMRLLFENDVRFLRQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.