PharMolix/UniProtQA huggingface dataset:
Protein: ADDA_CLOP1
Sequence: MGTKWTEEQELAINTRKCNLLVAAAAGSGKTAVLVERIIKMITEGENPVDIDKLLVVTFTNAAASEMRERIGDAISKALEKDPSSEALQRQLALLNRASITTMHSFCLEVIKNNFHLIDLDPGFRIGDQTECELIKQDILADLFEDMYAKDDECFKDLVEAYGGSKSDDNLNSIILKFYNFIMSGPWPETWLKDKVEEFNINSIEELEGKKWIEVLKESIILDLNNAYSMLTQARDIAEMGGGLEPYLVNIYPEIIQVEELRIALSEGIVKFYNKLMGASFGRLKSVRKASVDDERALEKAKSLRDESKKIIENLRDNVFETSLEEAVLGMKKMYPLMKCLSGLVIEFSNRYRDKKREKDILDFNDLEHLCLEILIDKDEEGNIKPSQVALEFKDKFEEVLVDEYQDSNTIQETIVGMVSRRDVENPNVFMVGDVKQSIYKFRQANPELFLEKYINYREFEDSNRKIMLYKNFRSREEIINGVNYIFKTLMSNTVGELEYDEKEALNLGASYGELNEENVEKEYIDEIENLKVAGDIELNILNKAGNKEYRDDDELGEEEEDLDSIQLEARIIGKKIKELMNPEDGSHYMVFDKDLGKYRRIKYKDIVILLRATKNWAETFVDELGTYGIPVYADTGTGYFQTIEIRTILALLHIIDNPMQDIYILSALRSPIFSFTSEEFADLRLLNKDKYFFEIIKEVVDGIYDESISKELKGKCKYFLDYLNKWREKAAYMPIDEFIWFLYSDTSYYGYVGTMPNGVQRQANLRILFQRAKQYESTSFKGLFNFINFINKLKKSSGDMGSAKILGENENVVRIMSIHKSKGLEFPVVILGGTGKQFNKMDLREDILLHETLGIGTNCIDVKKRIKYDTLQKHAIKKKCELEVLSEEMRILYVAFTRAKEKLIITGAVSDLEKSCENWCKASASSGDNRINPGNVLKGKSYLDWICMALTKHKDGDAIRNIGNGDITLNLDDKSNWSFKSWDRSELLETNNNKKEKNNIDIFESNNWIESKKDIKEVIEIRDRLGFKYKYIESCNTPSNISVTELKRAHQEEEFMQESYNIIDNESNEENKKEKIKRKPRFMEERQEEFSAAKKGTITHFVMQHIDLDKVTYIDEIREEVLKMVKKELLTEEEGKVVNVFKIQKFFKSDLGQRMLNSYKSGKKVYRELPFITEIPSSIIEKNLDPKIYGEEKVRLQGIIDAFFEEEDGYVLLDYKTDYVKEGEEEDFINKYKIQINLYKDTLNKILGEEVKEAYLYSFYLEKELKISKE
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: RL27_ALIB4
Sequence: MAHKKGQGSTQNNRDSAGRRLGVKKYGGEVVRAGNIIIRQRGTRVHLGQNVGMGKDHTIYSLIDGVVKFEQKDKNRKKVSVYAAS
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: LIS1_RAT
Sequence: MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
What is the function of this protein?
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation.  Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity).  Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors.  Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome.  Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate.  Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates.  During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules.  May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.  Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity).  May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).
What are the official names of this protein?
Platelet-activating factor acetylhydrolase IB subunit alpha, Lissencephaly-1 protein, LIS-1, PAF acetylhydrolase 45 kDa subunit, PAF-AH 45 kDa subunit, PAF-AH alpha, PAFAH alpha.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus membrane. Note=Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Redistributes to axons during neuronal development.
Protein: METAS_SHEON
Sequence: MPVKIPDHLPAAGILESENIFVMSETRAANQDIRPMKVLILNLMPNKIETETQLLRLLGNTPLQVDVDLLRIHDKESKHTSIDHMNTFYRDFEDVRHKNYDGLIITGAPLGQIDFEDVTYWDHIREIIDWSQQHVTSVLFLCWAAHAGLYHLYGLNRKILEQKRSGVFVHRRTCQHFPLLRGFDDEFFAPHSRFAEMDVEEIRQHPQLQLLAESDEAGAYLVLSRNNRNLFVMGHPEYQKSTLNDEYHRDLAQSLNPNVPQNYYRNDDPKADAIARWHSHGSLLVSNWLNYYVYQLTPYDLSDMTAMTPWESQ
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROM1_HUMAN
Sequence: MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH
What is the function of this protein?
May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617).  Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells.  During early retinal development acts as a key regulator of disk morphogenesis.  Involved in regulation of MAPK and Akt signaling pathways.  In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).
What are the official names of this protein?
Prominin-1, Antigen AC133, Prominin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the prominin family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.
Protein: RRP36_ASHGO
Sequence: MSYYFKNLQPGVDESSSEDELEQMLHGKQRADDASSEDDELSSLTFGSLKKAEDALQREEAHEAVHNRARAEARPRGSARSRQEASDSEDSSDSEAGFFEEDDRRRASGARRHKHAPSEQSAKRPVSKVRQIPGLESARREEPQPDIRFDKSLGRAEDLAKVRSNYRFLDDYRQQEISELSALLADKKFLRKASEREVQQLQQRLTSMRSRLQTVQNRDTERQVLRDYERSINQGNKTKFHLKKSEQKKVVQKWKFDHMKARQRDKVMERKRKKLRGKEFRSFEFHRK
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
What are the official names of this protein?
rRNA biogenesis protein RRP36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NHAP2_SHESM
Sequence: MDADSINSFFLIGALLAAVSVLLSPVSSRLGIPILLIFLAVGILAGEDGPGGILFDDYSTAYLVSNLALAIILLDGGMRTRVASFRVALWPALSLATFGVAITTSITGVMAAWLFDLHWLQGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGSNDPMAVFLTVTLIAILGNVDAELSASFMLISFIKQFGLGIFLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLMIYAASNKLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLLDIWLPGLALAFGMILFARPLAVWLSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPGAQLYFNLAFFVVLVSLLVQGASLTTAARLAKVELPPKPLPISRSGVEIYPSSEWEVFVYRLSENKWCIGEPLKRLSMPDGTRIAAVFRHNTLLHPSGSTCLEAGDILCVLGQEKSLEALSNLFSQAPETKEVPRFFGDFFIDTEVKLLDLAPIYGLELDEATGDMTVADLVAAELGSHPVLGDQFLWQSLHWVVAGLYEGKVTNVGIRLPAEA
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDRP_BRUA2
Sequence: MTRPLSYFHLHLISDATGETLLAAGRAAAAQYANARAIEHIYPLIRTEKQLRKVLEGIDAEPGIVLYTVVDQKLAAIIDESCADMGVPSVSVLEPVLNTFQSYLGAPAHRRASAQHVLNADYFRRIDALNFMMEHDDGQLPLDIEEADVIIVGISRTSKTPTSIYLANRGIKAANVPLVLGIPVPEILFAAKRPLIVGLVATAERISQIRQNRPLGNIPSLDTGLYTDRVSISEELAYARNLCNRHGWPIIDVSRRSIEETAAAILALLRNGKKEGSSS
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: OAZ1_XENLA
Sequence: MVKSSLQRILNSHCFAREKEGNKRNDAMPLLSIPSSSESSRASFNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHNLSANLFYSDNRLNITEELTSNNRTRILNVQSSLTDGKQVSWRAVLNNNNLYIEIPSGTLPDGSKDSFAILLEYAEEQLQVDHVFICFHKNRDDRAMLLRTFRFLGFEIVIPGHPLVPKRPDACFMAYTFERDSSDED
What is the function of this protein?
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels.  Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.
What are the official names of this protein?
Ornithine decarboxylase antizyme 1, ODC-Az.
What is the protein family that this protein belongs to?
Belongs to the ODC antizyme family.
Protein: THAP5_MACFA
Sequence: MMPRYCAAICCKNRRGRNNKDRKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIFSLPEDNQGKDPSKKKSQKKNLEDEKEVCPKAKSEESFVLNETKKNIVNTNVPPQHPELLHSSSLVKPPAPKTGSIQNNMLTVNLVKQHTGKPESTLETSVYQDTGIGDFHTCFEDLNSTTITLTTSNSESIHQSLETQDVLEVTTNHLANPDFTSNSMEIKSAQENPFLFSTINQTVEELNTSKESVIAIFVPAENSKPSVNSFISTQKETMEMEDIDIEDSLYKDVDYGTEVLQIEHSYCRQDINKEHLWQKVFKLHSKITLLELKEQQTLGRLKSLEALVRQLKQENWLSEENVKIIENHFTTYEVTMI
What is the function of this protein?
Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro).  May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase.
What are the official names of this protein?
THAP domain-containing protein 5.
What are the subcellular locations of this protein?
Nucleus.
Protein: CALM_BLAEM
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELLVMINEVDADGNGTIDFPEFLTMMARKMKDSDSEEEIKEAFKVFDKDGNGYISAAELRHVMTNLGEKLSEDEVEEMIREADVDGDGQINYEEFVKMMMSK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity).
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: FITM2_DROME
Sequence: MATKRRPLRPNLGGTAGSPSSSGSNMNFRPGGPDITRSEARGTRPTAAPTSIREILVMGVIHLCKKTIFFNTDLKVALYLGSLFVISVIGDFVPFPKTYFARSDNLFNQYFVKIGWGWTLLFVVPFLVLSAYTITCGDHKRMLRHHFPRIVIATFFWFFWTKLFNVVENSYGRCTTKGYATKSSCLKAGHLWKGFDISGHAFILIHSSLVLIEEARPIIRWETIKEHIRNERHNRSTAENSGTNPLRTLNEEQMRSLQFLYKRLTPIIRTLFIGMAALQLLWDIMLVGTMLYYHRMIEKVISGIIAILTWYFTYRFWYPTPGLLPEAPGNGSFSYQREIPTFPFKRPSHLSTGAATTSSGSNSSRTNLNGKAATTGVPRDQQIPTFMGMPLFTSPKAASAAANLLMSDQQKRERDREQQTLES
What is the function of this protein?
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity).  Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity).  This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (PubMed:28067622) (By similarity).  May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity).  May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity).  Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:28067622) (By similarity).  Required for correct morphology of nociceptive multi-dendritic sensory neurons (PubMed:28067622).  Required for normal mechanical amplification in hearing (PubMed:28067622).
What are the official names of this protein?
Acyl-coenzyme A diphosphatase FITM2, Fat storage-inducing transmembrane protein, Fat storage-inducing transmembrane protein 2, Fat-inducing protein 2.
What is the protein family that this protein belongs to?
Belongs to the FIT family. FIT2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NUSB_CHESB
Sequence: MTTPSKSPAENFRPANKRGAARLAAVQALYQMDVAGTGLLETTAEYEAFRLGKEIDGDLYREADAQWFRAILSGVIENQTFIDPVIRQSLTEDWPLSRLDSTLRAILRAGVYELSKRSDVPVPVVVSEYIDIAKAFYGEEEEPKLVNAVLDRVARRMRGEGKGKDPS
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: TNAA_HALS3
Sequence: MRSHTATMVDRIEDTSRADREAALADAGHNVFELASDDVAVDLLTDSGTGTMSNDQWAAMLQGDEAYAGSASFEDLAVAAEDVMGFQHIIPAHQGRGAENVLYGAVLSAGDTVLNNAHFDTTRAHVAANDATPVDCPVDGARDPDTDAPFKGNFSVERARRVVDDVGADAVPVVVLTITNNSMAGQPVSIENTREVAAFADDIDATFVIDACRFAENAHFVQQREPGYEHDSVAAIAREQLSYADACVMSGKKDGLVNVGGFVGLHDDGRLHEQCRQRGILYEGFSTYGGMSGRDMAAFAVGLREAVEPPYVAERVAQVQRLADALTDRDVPIYQPAGGHAVYIDANAALPHLPREQFPGQAFVCELYREGGVRAVELGRFAFPDTDRRDLVRLALPRRTYGPDHLDHVADTAAAVCERGTDVTGLEIVSEPELTELRHFSAALQPVA
What are the official names of this protein?
Probable tryptophanase, L-tryptophan indole-lyase, TNase.
What is the protein family that this protein belongs to?
Belongs to the beta-eliminating lyase family.
Protein: HIS6_BRUA1
Sequence: MTLKARVIPCLDVKDGRVVKGVNFVDLIDAGDPVEAARAYDAAGADELCFLDITASSDNRETIFDVVARTAEQCFMPLTVGGGVRQVADIRKLLLAGADKVSINTAAVKNPEFVAEAADKFGNQCIVVAIDAKKVSGAGENDRWEIFTHGGRQPTGIDAVEFAQKVVDLGAGEILLTSMDRDGTKAGYDVALTRAVADSVRAPVIASGGVGTLDHLVAGIRDGHATAVLAASIFHFGTYTIGEAKRYMAEAGIPMRLDPVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OMM64_ONCMY
Sequence: MLSRLLIVPLIFALAGLAISAPVNDGTEADNDERAASLLVHLKGDKDGGGLTGSPDGVSAGTTDGTDSSKELAGGAVDSSPDTTDTPDASSSDIFPDTNNRDTSVETTGNPDDSDAPDAAESAGSQDTTDAADASEAVAETVDTYDIPDTDGADDREKVSTEVSTEDLDSAGVDKSPESDSTESPGSDSAESPGSDSAESPGSDSTESPGSDSTESPRSDSTDEVLTDVQADSADVTSDDMDEATETDKDDDKSDDKSDADAATDKDDSDEDKDTELDGKAHAEDTQTEEAADSDSKQGAADSDSDTDDDRPEKDVKNDSDDSKDTTEDDKPDKDDKKNRDSADNSNDDSDEMIQVPREELEQQEINLKEGGVIGSQEETVASDMEEGSDVGDQKPGPEDSIEEGSPVGRQDFKHPQDSEEEELEKEAKKEKELEEAEEERTLKTIESDSQEDSVDESEAEPDSNSKKDIGTSDAPEPQEDDSEEDTDDSMMKEPKDSDDAESDKDDKDKNDMDKEDMDKDDMDKDDMDKDDMDKDDVDKDASDSVDDQSESDAEPGADSHTVVDEIDGEETMTPDSEEIMKSGEMDSVVEATEVPADILDQPDQQDDMTQGASQAADAAATALAAQS
What is the function of this protein?
Calcium-binding component of otoliths, a calcium carbonate structure of the inner ear involved in hearing and balance sensing (PubMed:18410381).  Binds calcium (PubMed:18410381, PubMed:28866388).
What are the official names of this protein?
Otolith matrix protein OMM-64, Otolith matrix macromolecule-64, OMM-64.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Note=Accumulates in the ring-like structures of otoliths.
Protein: HELC_ASPFU
Sequence: MNTAIITGAAQGVGLCIAEALAQRNYRIVLSDIDTEKGPAAASKLNLTHGEGTAAFFHCDLSNLREIDALLSFTIETMGGFSVLINNAGYLRAPFLALSAQDIQDMITVNLTAPIYATQQAIKYWDGLHQGQAGCVVSVTSSSSFKTYASIAPYGAAKAGAAMFTFAAGAFHPRVRVNAVAPTAIATGFDKNRMRVETDRTGPGYTPEEEMRAMGLKRLQPQEVAEAVVRCVEDKGLYGKVLYLDAVEGIKIHDGYT
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol)(PubMed:19415934, PubMed:19216560, PubMed:29158519).  The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid (PubMed:19216560).  Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton (PubMed:29158519).  This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order (PubMed:29158519).  The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21 (PubMed:29158519).  C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation (PubMed:19415934, PubMed:29158519).  The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC (PubMed:19415934, PubMed:29158519).
What are the official names of this protein?
Short chain dehydrogenase helC, Helvolic acid biosynthesis cluster protein helC.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RL19_CYTH3
Sequence: MSNLLKIVEQDYLAVQKALPEFKAGDTINVHVKIKEGAKERIQQYQGLVIQKRNSGNGASFTVRKISAGIAVERIFPTMSPFIDKIEVLRAGAVRRARLFYLRDKTGKNARIKEKKKPVVEAAK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ILVB1_ORYSJ
Sequence: MATTAAAAAAALSAAATAKTGRKNHQRHHVLPARGRVGAAAVRCSAVSPVTPPSPAPPATPLRPWGPAEPRKGADILVEALERCGVSDVFAYPGGASMEIHQALTRSPVITNHLFRHEQGEAFAASGYARASGRVGVCVATSGPGATNLVSALADALLDSVPMVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVLDVEDIPRVIQEAFFLASSGRPGPVLVDIPKDIQQQMAVPVWDTSMNLPGYIARLPKPPATELLEQVLRLVGESRRPILYVGGGCSASGDELRWFVELTGIPVTTTLMGLGNFPSDDPLSLRMLGMHGTVYANYAVDKADLLLAFGVRFDDRVTGKIEAFASRAKIVHIDIDPAEIGKNKQPHVSICADVKLALQGLNALLQQSTTKTSSDFSAWHNELDQQKREFPLGYKTFGEEIPPQYAIQVLDELTKGEAIIATGVGQHQMWAAQYYTYKRPRQWLSSAGLGAMGFGLPAAAGASVANPGVTVVDIDGDGSFLMNIQELALIRIENLPVKVMVLNNQHLGMVVQWEDRFYKANRAHTYLGNPECESEIYPDFVTIAKGFNIPAVRVTKKSEVRAAIKKMLETPGPYLLDIIVPHQEHVLPMIPSGGAFKDMILDGDGRTVY
What are the official names of this protein?
Acetolactate synthase 1, chloroplastic, Acetohydroxy-acid synthase 1.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SHSA5_CHICK
Sequence: MGFGTLVAIGVIVFAVVVITIILCLTCSCCCLYKACRRPQPVVTTTTATTVVHAPYPQQQGVPPSYPAAPYQGYQPVAIQPQPGMPVAPYPAQYPPPYPMQPPDPPAYHETVAAGAGAPYPISQPPYNPAYMDPQKPTY
What is the function of this protein?
Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
What are the official names of this protein?
Protein shisa-5, Scotin.
What is the protein family that this protein belongs to?
Belongs to the shisa family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane.
Protein: DPCKG_HALWD
Sequence: MDRLPLELPSSLRQEFKSPFGPVYTDVTQFLTDAGRPIIAVGDIVTYHLQTVDYTPAVAVIDGQTKRESVDETVKAALSKHNKRIDVENQPGTISIALLEALQTAVETPESVMIVVDGEEDLATLPAVLVARPGGTVVYGQPDQGMVRIAVTPETKITMSRLLKRMDGDAAAAFDRLGVDRSGDKK
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
What are the official names of this protein?
GTP-dependent dephospho-CoA kinase, Dephospho-coenzyme A kinase, DPCK.
What is the protein family that this protein belongs to?
Belongs to the GTP-dependent DPCK family.