PharMolix/UniProtQA huggingface dataset:
Protein: LVK55_HUMAN
Sequence: MALTPLLLLLLSHCTGSLSRPVLTQPPSLSASPGATARLPCTLSSDLSVGGKNMFWYQQKLGSSPRLFLYHYSDSDKQLGPGVPSRVSGSKETSSNTAFLLISGLQPEDEADYYCQVYESSAN
What is the function of this protein?
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447).  Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Probable non-functional immunoglobulin lambda variable 11-55.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: COLD_DICDI
Sequence: MIKVFKDLKFLILITIILLNLKSINCKIIYGDSVSFERVLSPQLGKNITLPWGKDKVIHLCNPHGEESIPVLVSNNIPLGKLASNDENFLAIFGNQSFARLLAHFNCKKTEETCIRLRTDLPVFTSCLLIGSVDGFDHVTFNSSLSGVPTNMNSWNVDTVGKFSNNLTSAGRIIVKNDNNQISLGCFEEGDKNNLNYILMHPNNPIDTIDICYKSFNEESEYVLYGLVECGDTSKSSFSISGYVFFDKYYSSSRINNPPVAGQIVYIQQKNGVVYDLDGKRVNQTITDARGFYYFNNIPGGDYQVYITPSDPDTLYSPDVDSNLQDPYTNKATNGSIETYIYINGSGVVPVSKTNFDDIKLTSVYVIREMNIGILPKNISMEGLVFIDYNANGQMDTAVTNTSAQDKPYSGVRVQLLDENRVVRDVITGDDGIFSFPDVPYVSTGYIAVIYTPSGNVMTNYPFPPSPLAGEIINLEIVPNNILLVGLINNENYCQDSPLMAIICYANQGYNESHADDPVLITFPSNANKHLYNMPHGTVQHIATHKEIGSVYGVGVDRVNGDIYTSAFMKYYSGFGPSGTGAIYKSTTKNNDYQTSLYFDLNKAMNQEDYCGTDSHIYPMDNYDGGVEKVGKIAFGDLDIHNGSLYTIALATKELLRVSISDPRDFQLYNIYNPCIEEPDDWRPFALGLRHGNIIIGGVCSKESDSTNIPVGYIMEMSGNILLTVPMDFPRGCKSFGGSFCIPGEYSAWSSVYFESQPWISDLTMDGEDMIISIRDRGGDLDRDVGTYDMLRACFDGDQLILENSGICGGVPGAHLLPSGYFGTPDGINSGEYYNDNFYYPTDNDGHDNVASTSGVVIPGYHTLFGSSLDIDSVGQGTVKVWDNKNGLLLYGIGVYLQSNENPTNNFGKANGLGDMEPICYNYIK
What are the official names of this protein?
Colossin-D.
What is the protein family that this protein belongs to?
Belongs to the serine-aspartate repeat-containing protein (SDr) family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECB_RHOPS
Sequence: MTNGNGAPPEAVAAPQLNVLAQYTKDLSFENPNAPASLAQQQQQPAINIQINVGANNLAENEYEVTLSVEGKAESGSTVLFSFELAYAGVFRIVNVPQENLHPLIMIECPRLLFPFAREIIASAVRDGGFPPLMLDPVDFVGLYRQNMERQAQQGQPS
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_RALPJ
Sequence: MSLLHQARFFITVNHLRDLPATAVPEVAFAGRSNAGKSTAINILCNQKRLAFSSKTPGRTQHINYFSVMPAKAEDPLGFLVDLPGYGYAEAPGETKSHWVHLLGDYVKARQQLAGLVIMMDARRPFTDLDCQMVEWFLPTGKPIHVLLTKADKLTNNDASRALMAARKVLADYRAQIDGDVSLTVQLFSSLKRRGIEEAQRIVAGWLCLPEALEAEPQAEPAKKTPSPNAQRG
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: HSCA_XENNA
Sequence: MALLQISEPGLSAAPHQRRLAAGIDLGTTHSLVAVVRSGQTETLADSENRHLLPSVVQYRKEDIQVGWQARQQAASDPVNTVSSVKRMMGRSLADIQKRYPNLPYQFQASENGLPLINTAAGLVDPIQVSSDILKSLAQRAEKTLDGKLDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDVSILRLSRGVFEVLATGGDTALGGDDFDLLLANWIREQAGISDNDHRLQRQLLDIATQTKIVLSEADSAEICFADWQGRITRNEFNELITSLVKRTLLSCRRALKDAGVTADEVLQVVMVGGSTRVPLVRNMVGEFFDREPLTSIDPDRVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQEFTTFKDGQSAMSIHVVQGERELVNDCRSLARFTLRGIPPLAAGGAHIRVTFQVDADGLLSVSALEKSTGIESSIQVKPSYGLSDEEIARMLKDSMTNAQEDIQVRKLAEQKVEAARVLESLTGALEKDADLLSQEEQVAIDAAVQALIESVQGTSPDAIESAIKQLDKQTQEFAARRMDTSIRRALAGHSVDEI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: SH_PIV5
Sequence: MLPDPEDPESKKATRRAGNLIICFLFIFFLFVTFIVPTLRHLLS
What is the function of this protein?
Inhibits TNF-alpha signaling and seems to block apoptosis in host infected cells.
What are the official names of this protein?
Small hydrophobic protein.
What is the protein family that this protein belongs to?
Belongs to the rubulavirus small hydrophobic protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein.
Protein: CRCB_PSEPW
Sequence: MLKSLLAIGLGAMVGAWLRWGLGMKLNALFPAVPPGTLLANLIGGYIIGLAIAFFSASPSLSPEWRLLLITGFCGGLTTFSTFSAEVVSLIQEGRILWALGSIALHVSGSLLMTAAGLATFYFISGR
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HXA3_HUMAN
Sequence: MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQPPQPAPQPPAPTPAAPPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPHAHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLGSGHHHGPGPGEPHPTYTDLTGHHPSQGRIQEAPKLTHL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A3, Homeobox protein Hox-1E.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFG_CHLPB
Sequence: MARQVGLANVRNIGIMAHIDAGKTTTTERILYYTGRLHRMGEVHDGGATMDWMEQEKERGITITSAATTCFWEPKGGNFVDVKHRINIIDTPGHVDFTVEVERSLRVLDGAVALFCAVGGVEPQSETVWRQANKYKVPRIAYVNKMDRVGADFYAAVKAVKERLGANPVPIQIPIGQGEIFAGVVDLIRMKGIIYDKEDGSTFEEVEIPHDLETEAKHWRINMLEAVSEVDETLLEKYLEGEDITEAEVRKVLREATLNGSIIPALCGSSFKNKGVQFMLDAVIEYLPSPVDVGSVTGHHPGDDSGISRKPSDDEPFAGLAFKIATDPFVGKLTFFRVYSGVLEAGSYVLNALTGKKERVGRLMQMHSNKREDRDAVFAGDIAAAVGLKDVKTGDTLCDAGKPIVLEKMVFPEPVIQIAIEPKTKADSDKLGVSLGKLAEEDPTFRVSSDEETGQTLIAGMGELHLEVLVDRLKREFKVEANVGQPQVAYRETIRGTVEHEGKFVRQSGGKGQFGLVNIKVEPLEEGKGYEFVDAIKGGVVPKEYIPAVSAGIQEAMKDGVVAGYPVQDVKVTLYDGKYHDVDSSEMSFKIAGSIGFKGAARKANPVLLEPIMKVEVITPEEYLGDVMGDLSSRRGHIDGMGERAGAQFVKASVPLAQMFGYSTVLRSMTQGRANYTMEFECYNEVPKSVAEALQEKSGVKGDG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_STRS7
Sequence: MTNEFHHVTVLLHEAVDMLDIKPDGIYVDATLGGSGHSAYLLSLLGDKGHLYCFDQDQKAIDHAQEQLKPYIDKGQVTFIKDNFRHLKVRLLEHGVTEIDGILYDLGVSSPQLDERERGFSYKQDAPLDMRMDSQAALTAYEVVNTYDFNDLVRIFFKYGEDKFSKQIARKIEQARAIKPISTTTELAALIKSAKPAKELKKKGHPAKQIFQAIRIEVNDELGAADASIQQAIELLALDGRISVITFHSLEDRLTKHLFKEASTADAPKGLPFIPDELKPKLELVSRKPILPSQKELMANNRAHSAKLRVARKVRK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y9381_DICDI
Sequence: MKLLSFKKKPSLTKSQSCPDKLKNLKEQQKDPKNGANYDTATIKSYTLQQHQQQQQQQREDNNMINNENEDFSFNYFDYDEDQESTYSREERLFFSIWRNNKIKRCIFHHLEIFNLMNNINDPITLDQLNLIDSGKLRDYCKIVKIEKNEKIELQCMPIPNHIEKLIFSNEFDKPIKAGTIPQSVVEIEFGEKFNQVLKQGQLPPSLEILKFGKRFNQMVTHSTGELPTSLTTLIFGNNFDQIILKNFIPPNVSTLIFGLNFDQPLSPGYIPSSVTKLEFQENFNQPLTIGTIPKNVKHLKIFSKFPLNQGAIPQSCTTLYYGGDCNQGTKNIPDSVKSLHFLQSIDCNNLTKERSLSKSSSSISLDISGGGSGSGSGVNSTTTSEKITFLQPESICKSVTNLTIELNQGPPNKKYLPMNSVTQLSLGINEFKKPLKSSYIPNCCTSLLLNIGPDYKFQQLLSKSIPSSVTALQFGPNFNLTIMPNSLPIHLRSIDFGDGFNQQLLQNSLPTLIDSIKFGNSYNQPISNNVLSNSNYLTSIEFGKSFDQPLIIGNGIGNLNNNNINNNVTNSNLPITLNKLKFSKDSNFKSLLKIESDSMIEEIEFGDQYNEEFNNQCSLGCTHLLSIKFGENFNQPINNLPISIKKLIFGNSFNQSIKNLPENLTSLSLGTSFSQNLINLPNSLIELKMFNKDFLNNLNFSNNNNENNNENNNENNNENNNENNNENNNNTNSFNDFIKNTTIKRIKVPCLITTLNFIVEKNKSKNCSLLKFYCFVVANNNYTNLVKYNLLLNKSYFEKWSKKKEGQSPRKQRKKKIPTDQRSTKLLLVRKFLYQVFFFFFFFFF
What are the official names of this protein?
FNIP repeat-containing protein DDB_G0289381.
Protein: AVH6_PHYSO
Sequence: MRLSSTTFVVLAAVLLASGTAVSKADETGVTNVNAVHSPNVLAGVDKRFLRSHHTEDGKAKLSNYDNEERNGLFAAGTLSDMANDMIFRFKMFTKWKANGHLPKAIKKDIPRSLYKAYKIHHRMN
What is the function of this protein?
Effector that suppresses plant defense responses during the early stages of pathogen infection.  Suppresses cell death induced by effectors and PAMPs in plant hosts (PubMed:21653195, PubMed:23550527).  Triggers a hypersensitive response (HR) in the presence of Rps1d (PubMed:23550527, PubMed:23594349).  Suppresses BAX-induced cell death and enhanced P. capsici infection in Nicotiana benthamiana.  Also suppresses effector-triggered immunity induction by associating with Avr1b and Rps1b, suggesting a role in suppressing plant immunity (PubMed:23594349).
What are the official names of this protein?
RxLR effector protein Avh6, Avirulence homolog protein 6, Avirulence protein 1d.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell.
Protein: DAPEL_BACAA
Sequence: MAVSKFVQIRRDLHKIPEIGFKEWKTQQYILDYIGTLSNEHVEVKVWRTGVIVKVKGKNPEKVIGYRADIDGLPITEETGYEFASVHEGMMHACGHDLHTTIGLGLLTAAVTERIDDDLVFLFQPAEEGPGGALPMLESEELKEWKPNIILGLHIAPEYPVGTIATKEGLLFANTSELYVDLKGKGGHAAYPHTANDMIVAASHLVTQLQSVISRNVNPLDSAVITIGKITGGTVQNIIAEKSRLEGTIRTLSVESMSRVKSRIEAIVAGIEASFQCEAVIDYGAMYHQVYNHEALTREFMQFVSEQTDMKVITCTEAMTGEDFGYMLQEIPGFMFWLGVNSEYGLHHAKLRPDEEAIEKAIVFLDQYVKWKGTRK
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: UXUA_SALAR
Sequence: MKQTWRWYGPNDPVTLSDVRQAGATGVVTALHHIPNGEIWSVDEIEKRKATVEEAGLEWSVVESVPIHEDIKTHTGQYDLWIKNYQQTLRNLAQCGIYTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFELHILKRPGAEADYTAEEIAQAGQRFATMSEEDKARLTRNIIAGLPGAEEGYTLDQFRQHLATYKDIDKAKLREHFAYFLKAIIPVADEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVETVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTLREENPKTFHEAAHLHGDVDMYEVVKAIVEEEHRRKAEGSDDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIKRAFFSK
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: AROK_SHESA
Sequence: MAEKRNIFLVGPMGAGKSTIGRHLAQMLHLEFHDSDQEIEQRTGADIAWVFDVEGEEGFRRREAQVIADLSEKQGIVLATGGGSVQSKDIRNHLSARGIVVYLETTIDKQVARTQRDKRRPLLQVDDPREVLENLAEIRNPLYEEIADVIVKTDDQSAKVVANQIIEQLGF
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1978_PYRNV
Sequence: MRRVVTLVSKEQAEVGHRFRVVEVPDECRTCRLYPVCMGRLTPGRAYKIVEVRPYMGQRCKITDGEMVPVVVEEAPMIGLVPLNKALEGVVVTFEGECAGCEGCPQQVQVGEKIKIVRVLGRAKCRGGDFAIVEFYALGPPSPSKSGGATASRDPSRAPPSRPLSK
What are the official names of this protein?
UPF0179 protein Tneu_1978.
What is the protein family that this protein belongs to?
Belongs to the UPF0179 family.
Protein: MURQ_CLOB8
Sequence: MESLNLKNLTTESRNETTINIDKVSTLEMVKIMNDEDKKVANAVEKELPKIAKAIDMIAERIHRGGRLIYIGAGTSGRLGVLDASECPPTYGVSEELVQGIIAGGKEAIFRAKEGAEDSEELAVEDLKSKNITENDTIIGLAASGRTPYVIGGLRYADQIGALTVSVTCNENSDVAKEAYISIAPVVGPEVVTGSTRLKSGTAQKLVLNMISTGVMIKLGKVYGNLMVDLRATNEKLIERAKGIVCKATGINMEEATEALNKTDYDVKLAIFMMLSKLNKDEARIKLDKNKGYIAKALQEIDNK
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: RPA2_MOUSE
Sequence: MDVDGRWRNLPSGPSLKHLTDPSYGIPPEQQKAALQDLTRAHVDSFNYAALEGLSHAVQAIPPFEFAFKDERISLTIVDAVISPPSVPKGTICKDLNVYPAECRGRKSTYRGRLTADISWAVNGVPKGIIKQFLGYVPIMVKSKLCNLYNLPPRVLIEHHEEAEEMGGYFIINGIEKVIRMLIVPRRNFPIAMVRPKWKSRGLGYTQFGVSMRCVREEHSAVNMNLHYVENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEEDSFFRNSVSQMLRIVIEEGCHSQKQVLNYLGECFRVKLSLPDWYPNVEAAEFLLNQCICIHLQSNTDKFYLLCLMTRKLFALARGECMDDNPDSLVNQEVLSPGQLFLMFLKEKMENWLVSIKIVLDKRAQKANVSINNENLMKIFSMGTELTRPFEYLLATGNLRSKTGLGFLQDSGLCVVADKLNFLRYLSHFRCVHRGAAFAKMRTTTVRRLLPESWGFLCPVHTPDGAPCGLLNHLTAVCEVVTKFVYTASIPALLCGLGVTPVDTAPCRPYSDCYPVLLDGVMVGWVDKDLAPEVADTLRRFKVLREKRIPPWMEVALIPMTGKPSLYPGLFLFTTPCRLVRPVQNLELGREELIGTMEQLFMNVAIFEDEVFGGISTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQNRSDNKLYRLQTPQSPLVRPCMYDFYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKFKQGEDNLVFGVKPGDPRVMQKLDDDGLPFIGAKLEYGDPYYSYLNLNTGEGFVVYYKSKENCVVDNIKVCSNDMGSGKFKCICITVRIPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMMPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGMELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPLGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHMCVECGSLLSPLLEKPPPSWSAMRNRKYNCTVCGRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors.  Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit.  Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
What are the official names of this protein?
DNA-directed RNA polymerase I subunit RPA2, RNA polymerase I subunit 2, DNA-directed RNA polymerase I 135 kDa polypeptide, RPA135.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome.
Protein: PRIO_RAT
Sequence: MANLGYWLLALFVTTCTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQSGGTWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWSQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMLHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSAVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: CHR41_ARATH
Sequence: MASTSTLLLPSLSSKNLHIAVPIRTNSFVRRTTKFSTKCSSNPESKDQFINLTPAPESINTTSAEKFPIEKRRRSEIIRDRTQRGIEKPEPPNFEIGWKRTKEINLEKPKGYVIMDFLEKFEALMAREFGSKELLAKAGEIVAERAREEAEVLRDEGKVEERMVTELFRVLKLMEMDLAMVKASVKDETLSQRIEQARARCRQAILVANSF
What is the function of this protein?
Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain (PubMed:22274627).  Functions in assembly or stabilization of the NDH complex; probably involved, together with NdhO and NdhH, in the formation of an NDH subcomplex A assembly intermediate (NAI500) (PubMed:22274627).
What are the official names of this protein?
Protein CHLORORESPIRATORY REDUCTION 41, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, chloroplast stroma.
Protein: SP5G_AGARV
Sequence: MQITDIRIRKVEKEGKMKAVVSITIDDEFVVHDIKVIEGEKGLFIAMPSRKANDGEYRDIAHPINSATRENIQNMILEKYKTEIENV
What is the function of this protein?
Could be involved in septation.
What are the official names of this protein?
Putative septation protein SpoVG.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: THIC_STRM5
Sequence: MNAQLSALQQQAQQLSESVTRPIPGSRKIHVPGSRPDLQVPMREIALTRTPTLFGGEENAPVTVYDTSGPYTDPEVRIDLSAGLPALRRGWVEERGDTERLEGLSSSFGRDREHDPKLDAVRFPARSLPRRARAGANVTQMHYARRGIITPEMEFVAIRENQRLEAIRDAGLLQQHPGEAFGASIQKIITPEFVRDEIARGRAVLPNNINHPESEPMIIGRNFLTKINANIGNSAVSSGIAEEVEKLVWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVAIGTVPIYQALEKVDGRAEALTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRVTGIVSRGGSIMAKWCLAHHKENFLYTHFEDICEIMKAYDVTFSLGDGLRPGCIADANDAAQFGELETLGELTKIAWKHDVQTMIEGPGHVPMQLIKENMDKQLRECGEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNRQDVRDGIMAYRIAAHAADLAKGHPGAQVRDNALSKARFEFRWEDQFHLGLDPEKAKEFHDETLPKDAHKLAHFCSMCGPHFCSMKITQDVREYAESGMKERSEAFRAAGAEVYHQG
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: SYA_LEPCP
Sequence: MKASEIRSTFLKFFESKGHQIVGSSPVVPGDDPTLLFTNAGMNQFKDVFLGFDKRPYSRATTSQKCIRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKHDAISYAWELLTEHFKLPKDKLWVTVYSEDDEAYEIWNKVVGVPAERIVRIGDNKGARYMSDNFWMMGDTGPCGPCTEIFFDHGEGIPGGPPGSPDEDGDRYIEIWNNVFMQFNRTEDGVMHKLPKPSVDTGMGLERITAVLQHVHSNYEIDLFVALLAAAKAAVESAGGKDVDPESPSLKVIADHIRACSFTIVDGVIPGNEGRGYVLRRIARRAIRHGYKLGARTPFFHKIVAELVAQMGEAYPELRAAQARVTEVLKQEEERFFQTIQHGMEILEHALAGGTKQVDGETAFKLHDTYGFPVDLTADVCRERGVTVDQAGFDAAMEHQRSQARAAGKFKMAAGLAYSGAPTAFHGYEHLVCETSKVVAIYVDGTPVDAAQAGDDAAIVLDHTPFYAESGGQAGDSGELRNGSTRVVVADTFKIQADVFGHHGRIVEGSVKVGDSFVAKVDAELRAKTVRNHSATHLMHKALREVLGAHVQQKGSLVNAERTRFDFAHNAPVSDAQIRQVEAIVNAEILANAAASAQVMALDDAQKSGAMMLFGEKYGETVRVLSIGSSKELCGGTHVKATGDIGLFKVVAESGVAAGIRRIEAITGDNALAYLQSLESTVNGVASALKSAVPEVPARISGLQDQVRALEKELAALKGKLASSQGDSLLAQTVDINGLKVLAVVLEGADAATLRTTMDQLKNKLKTAAIVLAAVDGGKVQLAAGVTADSTAKVKAGELVNFVAQQVGGKGGGKPDMAMAGGTDPSKLAAALASVPGWVGERV
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_PASMU
Sequence: MTKKKVKVGTNTIALNKRARHDYFIEDEMEAGLELQGWEVKSMRAGKANISDSYIIFKQGEAYLFGATIQPLNVASTHIVCDPTRTRKLLLKQKELASLFGKANRDGYTIVALSLYWKGAWAKLKIGLAKGKKQHDKREDIKEREWKVTKDRIMKNARLG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.