PharMolix/UniProtQA huggingface dataset:
Protein: PURA_CANAL
Sequence: MCDVVLGSQWGDEGKGKLVDLLCDDIDVCARCQGGNNAGHTIVVGKVKYDFHMLPSGLVNPKCQNLVGSGVVIHVPSFFAELENLEAKGLDCRDRLFVSSRAHLVFDFHQRTDKLKEAELSTNKKSIGTTGKGIGPTYSTKASRSGIRVHHLVNPDPEAWEEFKTRYLRLVESRQKRYGEFEYDPKEELARFEKYRETLRPFVVDSVNFMHEAIAANKKILVEGANALMLDIDFGTYPYVTSSSTGIGGVLTGLGIPPRTIRNVYGVVKAYTTRVGEGPFPTEQLNKVGETLQDVGAEYGVTTGRKRRCGWLDLVVLKYSNSINGYTSLNITKLDVLDKFKEIEVGVAYKLNGKELPSFPEDLIDLAKVEVVYKKFPGWEQDITGIKKYEDLPENAKNYLKFIEDYLQVPIQWVGTGPARDSMLEKKI
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBA4_KLULA
Sequence: MTETERSNESLLEEIENLRVENAKLKNDLCLERSLNNASDLPMSLDEFKRYGRQMIVDETEGLMGQLKLKNASVLVIGAGGLGCPSLPYLAGAGIGKIGIVDNDTVDTSNLHRQVLHDTIKVGMLKSESAKQVLNKLNPHVSVTSYPVRLSNENAFDIFKDYDVILDCTDTPMARYLISDVAVNLGKPVVSASALRTEGQLSIFNFDNVGPCYRCFYPTPPAPTSVSSCQEGGVLGPCVGLVGVAMVVEALKLLLGVYTRENFKPFLLQYSGFPDQTLRKFKMRGRRVDCPACGTGRTVTRESIESGKINYQSFCGSRNYSVLTEDERIDVHKFERDYWNSSKTKPYVLLDVRPSLHYSISHLPNSHNITVNELRDLPADLNNLQSKIPHLSADSEVLVLCRYGNDSQLATRLLKDKFNLKDVKDVKGGFFKYIDEINPSLPKY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1.  Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase UBA4, Ubiquitin-like protein activator 4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K6_VACCW
Sequence: MSANCMFNLDNDYIYWKPITYPKALVFISHGAGKHSGRYDELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGTARGNY
What are the official names of this protein?
Protein K6.
What is the protein family that this protein belongs to?
Belongs to the poxviridae K6 protein family.
Protein: RL28_PROA2
Sequence: MSKVCVLTGKRPKYGNTVSHANNHRRKRFEPNLHTKRVWLEEEKRWVKVKVSAKALKIMSRQGTAELAKLFK
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: COAD_BURMS
Sequence: MVVAVYPGTFDPLTRGHEDLVRRASSIFDTLVVGVADSRAKKPFFSLEERLKIANEVLGHYPNVKVMGFTGLLKDFVRANDARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVEKWLTEKVAAMAQGPSA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCHS_PSEE4
Sequence: MTLSSADQARLDQFWEHCLKNQYFNIGYPENADFNYAQLHRFLRFSINNCGDWAEPGNYLLNSFDFEKDVMAYFAELFSIPLEESWGYVTNGGTEGNMFGCYLARELFPTGTLYYSKDTHYSVAKIVKLLRIDCRAVESLPNGEIDYDDLMAKIAADQEQHPIIFVNVGTTMRGAIDNIATIQQRLEEVGIPREDYYLHADAALSGMILPFVDNPQPFNFADGVDSICVSGHKMIGSPIPCGIVVAKRENVERISVDVDYIRANDKTISGSRNGHTPMMMWAALRSHSPAQWRRRVRHSLNSAQYAVDRLQAAGIDAWRHDNSITVVFPCPSSRIARKYCLATSGDTAHLITTPHHQDKSMIDALIDEVIAEHQPNEWRAGLGLAGLDGVPPERVAASHFDVI
What are the official names of this protein?
Histidine decarboxylase, HDC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: ARFA_MYCTU
Sequence: MASKAGLGQTPATTDARRTQKFYRGSPGRPWLIGAVVIPLLIAAIGYGAFERPQSVTGPTGVLPTLTPTSTRGASALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN
What is the function of this protein?
Probably plays a role in ammonia secretion that neutralizes the medium at pH 5. 5, although it does not play a direct role in ammonia transport.  The OmpA-like domain (196-326) binds M. tuberculosis peptidoglycan.  Overexpression in M. bovis or M. smegmatis gives channels with average conductance value of 1,600 +/- 100 pS, but this may not be physiologically relevant.
What are the official names of this protein?
Peptidoglycan-binding protein ArfA, Outer membrane porin A, Outer membrane protein A, OmpATb, Outer membrane protein ArfA.
What is the protein family that this protein belongs to?
Belongs to the outer membrane OOP (TC 1.B.6) superfamily. ArfA family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell outer membrane. Note=Does not have a cleavable signal sequence.
Protein: RSMC_ALTMD
Sequence: MILSPQSQLLERNIALFDEGQWAFINPSDAYFLDGLKSQEVTVIHQYFDIFAECVRVIPSASFDSRDITSKGFEVSQKVGNHTHIFTPFVALEKSHTDVMISLPKAKTHFQMLLRMAASMVGQNGRIHVVGENKGGIKSAAKLMQQYGATQKVDSARHCSLITVIVEAPHLAFEAEAWIDTNTYAVEGTSWKVASMPGVFSYKELDAGTELLLEKLSTSLSGDVLDFACGAGVIASYIMLKYPHLKLHLTDVSALAIYCSALTLAENQLAATLYAADGLHGMTNKVQHIVTNPPFHTGIKTDYTVTKRFISDAKARLTRGGTMQMVANRFLPYPGLLSEHFQTVYTTAQTSQFSVYQATL
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYNS_SORBI
Sequence: MEASGERAAVVRRLMEVKEESGKTFSEIAAETGLTNVYVAQLLRRQAHLKADTVPALRAALPTLTDELVQLMMQPPFRSYNPDIVQEPAIYRLNEAVMHFGESIKEIINEEFGDGIMSAIDFYCSVDKVQGADGKDRVVVTFDGKYLPYTEQKSEHMMSRPTRKTS
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: ERT1_COPC7
Sequence: MFAVAPRPAPLAPAQAGPSTSPQQTLKKSSSQSSITSAPTKRRRTVTPEDSPQDSAPSQPQKKAREGPKKKKANRACFHCQKAHLTCDDSRPCQRCIKRGIANNCREGHRKKAKYLLDDDELEALKRSKEGAKGKAPEPQPQPQLHQPVVATMPISEPVPQSEQLLTTAFDPTTFAFGSEAANLEYSILSAILGNPSPPDSASSPPPPPSQSHYSWPSDPLDFTASPRLGTSFTSSYTDAQQLSISSDSVLSTSPSAQFLNYSYSQQQRSDEGSDLPYSQYSAQAPLHPLQPRYPLDQRPRSPPTSTVGEKVSTDVASRGLLTPPLSNASPSSIASVPPGVAEIPQPKSAVSHLQSINDRVTKPYDYTEGYHFLMKHLPTRFEKNDILRVVRALAIFRPSLIALQMPLSLDDEIFVEKCFQRSLLELGKLISYSGTPTVVWRRTGEICLVAPEFCMLTEWPMEELVGRRKYIYELFENQSVVEYWENFASHAFENTTRSVYSHCVLLKPDGTPVPATFCFSIRRDLFDLPSMVIGQWLPLL
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes (By similarity).
What are the official names of this protein?
Transcription activator of gluconeogenesis ERT1.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IGMT3_ARATH
Sequence: MGYLFEETLSSNPKTPIVVDDDNELGLMAVRLANAAAFPMVLKASLELGVFDTLYAEASRTDSFLSPSEIASKLPTTPRNPGAPVLLDRMLRLLASYSMVKCEKVSVGKEQRVYRAEPICRFFLKNNIQDIGSLASQVIVNFDSVFLNTWAQLKDVVLEGGDAFGRAHGGMKLFDYMGTDERFSKLFNQTGFTIAVVKKALEVYQGFKGVNVLVDVGGGVGNTLGVVTSKYPNIKGINFDLTCALAQAPTYPGVEHVAGDMFVDVPTGNAMILKRILHDWTDEDCVKILKNCWKSLPQNGKVVVIELVTPDEAENGDINANIAFDMDMLMFTQCSGGKERSRAEFEALAAASGFSHCQFVCQAYHCWIIEFCK
What is the function of this protein?
Involved in indole glucosinolate biosynthesis.  Catalyzes methoxylation reactions of the glucosinolate indole ring.  Converts the hydroxy intermediates 4-hydroxy-indol-3-yl-methylglucosinolate (4OH-I3M) and 1-hydroxy-indol-3-yl-methylglucosinolate (1OH-I3M) to 4-methoxy-indol-3-yl-methylglucosinolate (4MO-I3M) and 1-methoxy-indol-3-yl-methylglucosinolate(1MO-I3M), respectively.
What are the official names of this protein?
Indole glucosinolate O-methyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: DHPH_CALTT
Sequence: MSTVTFDQISEHEQVMFCNDPHTGLKAIIAIHNTTLGPALGGCRMLPYKSEEEALTDVLRLSKGMTYKCVAADVDFGGGKAVIIGDPRKDKTPELFRAFGQFVQSLNGRFYTGTDMGTTPEDFVQAYKETSFIVGLPEEYGGNGDSSVTTAFGVMQGLRAVSQFLWGTDVLTERVFAVQGLGKVGFKVAEGLLKEGANVYVTDVDPETIAKLEEKAYQYPGHVQAVTADDIYGVGADVFVPCAIGGIINDETIERLKVKAVCGAANNQLLEDRHGKVLQAKNILYAPDYIVNAGGLIQVSDELYGPNKARVLKKTRALYDTLFEIFQSAEKKAVSTVEAANQFVEERLQKRARLNSFFSPDNPPKWRVRR
What is the function of this protein?
Catalyzes the reversible NAD(+)-dependent oxidative deamination of L-phenylalanine to phenylpyruvate.
What are the official names of this protein?
Phenylalanine dehydrogenase, PheDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: SEC8_YEAST
Sequence: MDYLKPAQKGRRRGLSINSLSETQQSAMNSSLDHLQNDLNRINLQWNRILSDNTNPLELALAFLDDTSVGLGHRYEEFNQLKSQIGSHLQDVVNEHSQVFNTNVASYGKAVSSIMQAQEQTLNLKNCLKEANEKITTDKGSLQELNDNNLKYTKMIDVLVNIEELLQIPEKIEENIRKENFHQVQILLERGFILMNNKSLKTVEILKPINQQLELQEHLLFNNLIEEIHDIMYSKSNKTNFTRVTNNDIFKIISISHNGFTSLENYLYNIVNIDIMEHSKTINKNLEQFIHDQSLNKGNIMLQENAATQAPLAPSRNQENEGFNRIGFLLKTINNINKLPVAFNIITERAKEEIHNIIVKSTESIRSKHPSLLKMATSLKNDNHFGLPVQDILSIILRECFWEIFLKLLYAIQCHRAIFEMSNILQPTSSAKPAFKFNKIWGKLLDEIELLLVRYINDPELISSNNGSIKPINGATNNAPTLPKRKNPKIFSLEYNIEDNSSVKDQAFELKALLKDIFPGFSVSSNMDLDSIYVKDESFEQDEPLVPPSVFNMKVILDPFLLFTQSTSTIVPSVLTQNTISSLTFFDDYMNKSFLPKIQMTMDYLFTVEVESNNPYALELSDENHNIFKTALDFQRLFYNLLNVFNTANTFREKISYCILDLLNHFYNYYLGLFNSLIGTSDRHLTRKIITAWLQNGILMDQEQKILNGDETLFHEESIELFKEIPHFYQAGKGLSKSDLFNNLTLDTILQFSASVLWILNWLPGLKKAINIDEVSQEPMLDADRLRSSWTFSESMDLNYSNPSSSPNSLGNLKILLDDKASKKFDETIDGFKTLKFKLITILRFNIRALCIYDIGSFFQNTKIWNMDVGSIELDQNIASLISELRRTESKLKQQLPEKEKNSIFIGLDIVNNYALIKGAKSIKVLNHNGIKKMLRNVNVLQHAYRNLSSEPSKINMNVTMNFYSLCGSSEAELFEYIKDNELPHCSVEDLKTILRLQFSEEMHRQLKRQSTSSTKGSIKPSNKRYTEALEKLSNLEKEQSKEGARTKIGKLKSKLNAVHTANEK
What is the function of this protein?
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
What are the official names of this protein?
Exocyst complex component SEC8.
What is the protein family that this protein belongs to?
Belongs to the SEC8 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=75% cytoplasmic. 25% associated with the cell membrane.
Protein: YFH7_YEAS1
Sequence: MVDTHKLADDVLQLLDNRIEDNYRVCVILVGSPGSGKSTIAEELCQIINEKYHTFLSEHPNVIEVNDRLKPMVNLVDSLKTLQPNEVAEMIENQGLFKDHVEDVNFQPIKYSALTSNNEECTAVVARGGTANAIRIATVDNPVNVNKLAQDSINIAQIVPMDGFHLSRRCLDLFKDPQTAHKRRGSPSTFDSNNFLQLCKILAKTSLCKVSSHHKFYSTSSVFEKLSKTFSQTIPDIFVPGFNHALKDPTPDQYCISKFTRIVILEGLYLLYDQENWKKIYKTLADTGALLVYKIDIDYEATEERVAKRHLQSGLVTTIAEGREKFRSNDLLNGRDIDNHLIKVDNIVHIRND
What is the function of this protein?
ATP-dependent kinase that could be involved in endoplasmic reticulum membrane assembly.
What are the official names of this protein?
ATP-dependent kinase YFH7, Altered inheritance of mitochondria protein 12.
What is the protein family that this protein belongs to?
Belongs to the YFH7 family.
Protein: TACO1_RAT
Sequence: MMSWAAARLTETAARCFRARCLGFRVGPWCVSQHENSSYGAAPHRTLRVSAVAFAGHNKWSKVRHIKGPKDMERSRIFSKLTLSIRLAVKEGGPNPENNSSLANILEVCRSKNMPKSTIESALKSEKNKGIYLLYEGRGPGGSSLLIEALSNSGPKCHLEIKYILNKNGGMMTEGARHFFDKKGVVVVGVEDREKKAVNLERALELAIEAGAEDVREAEDEEEEKNLFKFICDASSLHQVRKKLDSLGLCSVSCSLEFIPHSKVQLSEPELEQAVHLIQALSNHEDVIHVYDNIE
What is the function of this protein?
Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.
What are the official names of this protein?
Translational activator of cytochrome c oxidase 1, Coiled-coil domain-containing protein 44, Translational activator of mitochondrially-encoded cytochrome c oxidase I.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PI51N_PLAF7
Sequence: MKCTSVNIRNVLDISLKKKIKENTNLSDDEIIIIYKRFNYISSNGKLNYDNFEKSLGILGSIQNAYLYKSIFKAFDLNNDNYLDFYEFCVAINIMLKGNKKDKLKLSYRIVNAGFNSNEDACVHKSSCMVNKFNTKEDNNMNGDNINGDNNNNHNNINGDNNNNHNNINGDNNNNNHNNINGDNNNNHNNINGDNNNNNHNNINGDNNNNHNNINGDNNNNHNNSHNNNSHNNNNKAENSLGQPLNEKNINDPINKHRNSQSIIYNINDEYNEKIKKNKKQDYSNYITYENFEKIVLSINDIKRQLLGTGDEIITSQIKYTFRSLSILCDDGIYRMNFECYKKALKCNEFLKLLGIHTKVADVFLQHELLKRKDKNKTKNGTMRNRKKYKNDSNRIANHLIIKSFSESTNTRGSIINDSTSFLFLRKQKKKKKKKKKKKKKKEKKAILYERKSTFSSSMENKSQNKSQNKSHNKNIKSVSRILSRVNKLSSTELIPNECDHKPNEEVKSTSDVLTPIFFNNGDEKMNHDTDGNMVYHKNNVDDNLVDGDVVSQGKRCSFFSSCENKKNEENKSITFNDINSGNINTNSCIMNNMIVTKESNEEIINEEAQSSYIYNKNIFCSKYNTKKDKNEPLKCDLFECSFINNDKNIVRDEDSNHKNVRKTDDYFIIDDNNIFDNGPIIISKNKTNDRERKLLKTFSSSSLKKKSLLKNYNYHIKKKNKDPNVEDTNMLYHDDIKKEYDHKVTKNNKNTCNNNYYNNVSFNSSAYYEYHSDIDLIHFSNNLKKKKKKNVTSPRPSSKEYERKVTYHKECCSNERMKNIKVNESDLGMFCVNNDKTNIEDVKEKKACDVLNRGCIKEQVQCKISEFENDKGNEIYMQEFKKCIEKYKEYVNQGEGHLKDEEEEKNDDEEEGEDGEDDEEENDDDDDDEDGDDDEDGDDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDEKSNIKIENKKDVPNIHNNNDDDGINCCTNLFKDDDTLSALEKNVTNNNLIKIMSAKYLYHKFLEYKDFMKNNTTLFSHFNKIYQHEDDKINTDNKDVLNYRPKHNNDINYYNIPCEDQIKSDEKKSLLNVEFGDDIIKKKFFISSVNSHYVMINNNLTKEQMLYLIRNILMSIEDYLKKEKNRDYNKIFFLFFSIFIYNTQNGGDQKEMHEDEKWDHTNINEDKNVEKNDDYKNLSNNENSVYYNTMLRESLWNKKKYIKLNIFKNIILVISIVRYFLHTITISQKYTSSYDSLDDSNMIKSMNSLKLNEINILLNRASEILEKYSLGSVENKKVYINKSNYYNSSKKGKLSVSLRQNKQKKTFHRILAVYFGHERWDLVMNMMIGIRISSIKKFSINDISNYFHHKDVIQLPTSNAQHKVIFKNYAPIIFKNIRNFYGIKSKEYLTSVGPEQVISNMVLGNLSTLSELLSEGKSGSLFYFTSNGKYIIKTVCRNIHNLSKKLLPKYYEHIKKNPDSLLTRLYGIHSIKYQNNLGRKKKKIYFIVMNNFFSSIVEIHRRYDIKGSLVGRTVPETKREDHTIALKDVDIDELGDIINIGPENKERLLKVLKADADFLKENMLLDYSLLFGIHYRELSKDVVNWEETKTNQINHIYDYKGNCIASRPFHQCDYGGIISVDKKKIFFFGIIDIFTKWSIKKKFEHTFRTIQKFDGKNISCIHPNAYAKRFVTFIENHMK
What is the function of this protein?
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes.
What are the official names of this protein?
Phosphatidylinositol 4-phosphate 5-kinase.
Protein: IKBI1_MDBVW
Sequence: MVPPEEIASASNPDIEGENILHFLCREGDITDLMAFKNVISDANRHLVLQFNRHGKQCVHIVSNPGIADPQEKLKLLMEWGADINGQERVFGNTPLHIAAYTQNHKLATWLCNQPGINMGISNYLFKTPYYVACERHDIKIMNILRAKGGQCRIYRCNEAWLFTRNY
What is the function of this protein?
Suppresses the host immune response through NF-kappa-B inactivation.  Possesses ankyrin repeat domains required for NF-kappa-B binding but lacks the regulatory regions required for dissociation from NF-kappa-B and degradation.  Therefore, prevents host NF-kappa-B release and subsequent activation (By similarity).
What are the official names of this protein?
I-Kappa-B like protein I1.
What is the protein family that this protein belongs to?
Belongs to the polydnaviridae I-Kappa-B-like protein family.
Protein: PURA_ARTS2
Sequence: MPAIVIVGAQWGDEGKGKATDLLGGRVDYVVKPNGGNNAGHTVVVGGEKYELKLLPAGILSPNAVPIIGNGCVVNLEALFQEIDGLEARGADTSKLRVSANAHLVAPYHQVLDKVTERFLGSRAIGTTGRGIGPAYMDKVARLGIRVQDVFDASILRQKVEGSLRQKNELLVKVYNRRDIEVDEIVDYFLSFAERLRPLVIDSTYVLNTALDEGKVVLMEGGQATFLDVDHGTYPFVTSSNPTAGGASVGSGIGPTRISRSIGIIKAYTTRVGAGPFPTELFDEMGMYLQKTGGEFGVNTGRPRRCGWYDAVLARHASRVNGFTDYFVTKLDVLTGIEQIPVCVAYDVDGVRHDEMPMTQTEFHHAKPIFEYFEGWTEDITGARTLEDLPENAKNYVLALEKLSGTRFSAIGVGPDRDQTIVVNDLIND
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_ANAMM
Sequence: MLFRAMGYVIAAFYRFVHLHNYYDMKPVILEFCLSRGIKGTVILAEQGINATIAGSRQSIGEFFSFLDSDDRLRGMKYHESHSDREPFAKMKVRLKREVVRLGIDGFDCSLRGEYIDPRDWDEFVSSPDVHVIDTRNDYEVRLGRFKGAIDPGTSSFREFPEWARNWALDKERDTCVAMYCTGGIRCEKSTAFMRSLGFRNVYHLRGGILNYLETMRGDDSLWEGECFVFDDRIAVDRNVSPSEDIKCIKCAGEVDASDLRSVSKGNIMCWDCRLQA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: HTPX_RHIL3
Sequence: MNLVRTAMLLAFMTALFMFVGFLIGGRAGMMIAFVIAAGMNFFSYWNSDRMVLSAYRAQQVDERNAPEFFRIVRDLARNAGLPMPKVYLYDSPQPNAFATGRNPENAAVAASTGLLSALSAEEVAGVMAHELAHIQNRDTLTMTITATLAGAISMLGNFAFFFGGNRENNSNPLGFVGVIVAMIVAPLAAMLVQMAISRTREYSADRRGAEICGNPLWLASALGKIARGAAHVPNEDAERNPATAHMFIINPLSGERMDNLFSTHPNTENRIAALHDMAQSGMNVSTSPARAANPSRKSRSVPDTGLGRGGSQPPKGPWS
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURE_PROM1
Sequence: MSRYLHTLLKAIDLQVRSGLANPEIKNLSTDSREIEKGDLFLGLDGEKVDGGTFWAKAIERGACAAIISKKASLLNPPTNEDPVVILPEPVSLFMGKLAADFWGKPSSEICLIGITGTNGKTTTSFLIEFLTTSLGHPSALFGTLINRWPNYEETSKYTTTFAVPLQAKLRKAVQAGVEYGAMEVSSHALSQNRVAGCDFNGAIFTNLSRDHLDYHDSMESYFEAKASLFRSHLIDDDGPRSVINIDDKWGSILAKELNKKCWTCSLKENSQIREKPDLYISNLQIMQDGYMGKLHTPFGVGNFISPLIGEFNLMNMLQAIGILVQRGLPLNDLLEALNKFPGVPGRMQLINMDGFKVKDGYPLVIVDYAHTPDGLQNALIASRSLTKKRLICVFGCGGDRDKGKRSKMGEVAAKFADYIVVTSDNPRQEDPIEIIKDIQKGITIDSEISVEPERSIAIQFAIAKAKKNDVVLIAGKGHEDYQILKDQTIYFDDREQARKALSLRTDVI
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1A1D_AGRRK
Sequence: MLEKFERYPLTFGPTHIEKLERLSEHLGGKVQLYAKREDCNSGLAFGGNKLRKLEYIIPDAIASNADTLVSIGGVQSNHTRMIAAVAAKIGFKCRLVQESWVPHEDAVYDRVGNILLSRIMGADVQMVDEGFDIGIRQSWEEAIEDVKAKGGKPYPIPAGASVHKYGGLGYVGFAEEVRVQEEELGFKFDYIVVCTVTGSTHAGMTVGFAKDGRERQVIGIDASFTPAQTKAQVLEIARRTAELVELGRELSSDDIVLIEDYAYPVYGVPSDETKEAIRLCARLEGMITDPVYEGKSMQGMIDLVKKGYFPEGSKVLYAHLGGAPAINGYAYTFRNG
What is the function of this protein?
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate.  Allows growth on ACC as a nitrogen source.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate deaminase, ACC deaminase, ACCD.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: CASP1_FELCA
Sequence: MADKVLKGKRKQFINSVGMGTVNGLLDELFEKNVLNQEEMERVKCENATVMDKARALIDSVLRKGPRACQIFICHICEEDTHLAETLGLSSSPQSGNSQNTTDSEVAFPPLPASVNNMPGPAEPEESVDALKLCPHENFVKLCKQRAEEIYPIKERKDRTRLALIICNTTFDHLSLRKGADLDVAGMRRLLTDLGYSVHIKEELTAKDMESELRAFAARPEHKSSDSTFLVFMSHGILSGICGTKYSAEGDPDVLAYDTIFQIFNNRNCLSLKDKPKVIIVQACRGENLGELLISDSPAAPMDSTSQMGSSLSQVGDNLEDDAIYKVHVEKDFIAFCSSTPHHVSWRDVNKGSLFITQLITCFQKYSWCFHLEEVFRKVQQSFEKPNVRAQMPTIERLSMTRYFYLFPGH
What is the function of this protein?
Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides.  Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes.  Cleaves a tetrapeptide after an Asp residue at position P1.  Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD.  In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part.  Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.  Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive.  In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.
What are the official names of this protein?
Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.
Protein: YJLA_BACSU
Sequence: MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVPFLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSGRMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWWSDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALLGEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA
What are the official names of this protein?
Uncharacterized protein YjlA.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNH2_SALPB
Sequence: MIEFVYPHTHLVAGVDEVGRGPLVGAVVTAAVILDPARPIVGLNDSKKLSEKRRLSLYDEIKEKALSWSLGRAEAHEIDELNILHATMLAMQRAVAGLHIAPEYVLIDGNRCPALPVPSMAVVKGDSRVAEISAASILAKVTRDAEMAALDIVFPQYGFAQHKGYPTAFHLEKLAQYGATAHHRRSFAPVKRALGLVS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_CAMLR
Sequence: MTKSQKIELVSKLEEGFKASEAVVVCNYKGLNTKKLEELRNNAREMDVKVQIIKNTLASIALKNAGKDGMELKDTNIYLWGEDQLNVSKVADKFSEANQTFEIKTAFIDGEVASVDKVKALAKMPSRNELLAMLLQVWNAPITNFTIGLNALKEKKEAE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.