PharMolix/UniProtQA huggingface dataset:
Protein: RL22_RHOPB
Sequence: MSKPKRERSLPDNEAKAIARMLRVSPQKLNLVAQLIRGRKASAALADLQFSRKRIAVDVKKCLESAIANAENNHDLDVDALIVSEAHVGKGIVMKRFAPRGRGRSGRIFKPFAQLTIVVRQVEAEASA
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: MNME_CROS8
Sequence: MSHNDTIVAQATPPGRGGVGILRVSGQQARNVAQAVLGKLPKARYADYLPFKDADGTALDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTLPGVRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIFVEAAIDFPDEEIDFLSDGKIEAQLNEVIGDLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWQEIEQADRVLFMVDGTTTDATDPAQIWPDFIARLPAKLPITVVRNKADVTGEQPGISEVNGHSLIRLSARTNEGVDVLRNHLKQSMGFDTSMEGGFLARRRHLQALEDAANHLQQGKAQLLGAWAGELLAEELRLAQQALSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_BEII9
Sequence: MFADLIPRLRDAMPELRGELQTNVPLAPWTWFKTGGPAQCVYVAPDVEDLAYFLGNLDPDISIFVLGLGSNILVRDGGIEGVVISFGPSFHKIVIEGDTISAGAAVADVKLASAAAMAGLGGFAFLRGIPGTIGGALRMNAGAFGGTIADILVSCEGLDRRGALHHFTPEEMGFSYRHCAVEGIIFTQGLFAGWPENPEKIREDMGKIAQERAKTQPVNTRTGGSTFKNPNGAKAWELIDRAGCRGLTLGDAQVSELHCNFLVNRGKASAADIENLGEMVRQKVLAETGVELEWEILRVGRPPVAHKTSR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCDH_STRA3
Sequence: MMKIKPVKVESIENPKRFLNSRLLTKIEVEEAIEKALKQLYINIDYFGEEYPTPATFNNIYKVMDNTEWTNGFWTGCLWLAYEYNQDKKLKNIAHKNVLSFLNRINNRIALDHHDLGFLYTPSCTAEYRINGDVKALEATIKAADKLMERYQEKGGFIQAWGELGYKEHYRLIIDCLLNIQLLFFAYEQTGDEKYRQVAVNHFYASANNVVRDDSSAFHTFYFDPETGEPLKGVTRQGYSDESSWARGQAWGIYGIPLSYRKMKDYQQIILFKGMTNYFLNRLPEDKVSYWDLIFTDGSGQPRDTSATATAVCGIHEMLKYLPEVDPDKETYKYAMHTMLRSLIEQYSNNELIAGRPLLLHGVYSWHSGKGVDEGNIWGDYYYLEALIRFYKDWELYW
What is the function of this protein?
Catalyzes the hydrolysis of unsaturated hyaluronate and chondroitin disaccharides.  Also degrades unsaturated heparin disaccharides.  Releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds.  Prefers sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans.  Probably required for mammalian cells invasion through the degradation of extracellular sulfated glycosaminoglycans such as chondroitin and hyaluronan.
What are the official names of this protein?
Unsaturated chondroitin disaccharide hydrolase, Unsaturated glucuronyl hydrolase, SagUGL.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 88 family.
Protein: TPMT_BORPA
Sequence: MDADFWLDRWREGRTHFHQTRVTPLLQKYWPALDVPAGGQVLVPLAGKSLDMVWLAGQGLRVLGVELSQLAVEQFFDENGLRPEIHQSAQGRHYVAGNLELICGDVFALEDATLAACAGVYDRAALVALPEPMRKRYAREVYGRLGRGCRGILITLDYPQDQMEGPPFSVDDAEVQALYAGHTEARLIDRRDILDKEPKFNQRGVARLDTLVYRLERLG
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_METAC
Sequence: MTDREQFFRDVNKIVIKIGTSSITRKGCDHTKENCNIDPAFMESIAAQVYELRKHGKEVILVSSGAIGVGLNELGIAPKPREIPIRQAAAAVGQSILMQDWSRAFSKYGMKVAQILLTYEFYSDRVTYLNLRNSISTLLEYEVVPIINENDCTCTNEIEAIFGDNDKLSAMVASKIDADLLIILSDIDGLFDRNPKTHSDAKLLTLIKKITPEIESYGGDPTNFKGVGGMRTKIKAAKICSMAGCYVVIANSEIEDVVTKILSGEEIGTLFLAERHIQKNRARWIILARASGTVRVDAGAKAAVLGKNSLLPAGIVDIEGTFDRGDVVKLECEGKVFAKGITNYTSKELIKIKGAQTNQIDNILGYNNYDNVIKKENIGILEGIN
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y636_METJA
Sequence: MLFGESMTLKIAVVGAGPAGRTSAMFLAKNGFDVDLFEKDRVGGTCLNYGCTYITGLREMADIINNLSILKGEKVHLEEIISFKELQEKINKIQDRIRNKLEKETKELGVNIKYKEFKNKHKNDYDYIIYATGRNYPSNYNGYEVLTHKDIPNLRELPENILIIGGGVVATEYASIFSDFGCNVVLYTRSKILKEIKDEEIRDYLMKKVINFKIINDKEELENLLKDESYTKILAIGGNGRFKTDDYLRVLNEEKVYACGDCLINGGGNTPISRMEGRVVAQNIYNEINNKPLIKPNYELIPKTIRLSLTISYVGKQTNNYKTIRSCVGKGNFFKVLSGVGINKIYYEDGKIVGAITMMPCAEILPYFTQLIRGIDVYNNFMEVHPSTDIFYKEFRS
What are the official names of this protein?
Uncharacterized protein MJ0636.
Protein: CHK1_XENLA
Sequence: MAVPFVEDWDLVQTLGEGAYGEVQLAVNRKTEEAVAVKIVDMTRAADCPENIKKEICINRMLSHTNIVRFYGHRREGNIQYLFLEYCRGGELFDRIEPDVGMPEQDAQKFFQQLIAGVEYLHSIGITHRDIKPENLLLDERDQLKISDFGLATVFRHNGKERLLNKMCGTLPYVAPELIKSRAFHADPVDVWSCGIVLTAMLAGELPWDQPNEVCQEYCDWKEKNHYLTPWKKISATPLALLCKMLTENPQSRITIPDIKKDRWFTEIIKKGLKRSRVISGGSSDSSVLCKQIRSDIDISHFSHSEEKTALSSTQPEPRTALATWDSNSSYIDNLVQGKGISFSQPACPDNMLLNSQLIGTPGSSQNVWQRLVKRMTRFFTKVNAESSYSNLMDTCEKMGYVLKKSCANEVTLSTTDRRNNKLIFKVNLVEMEDRILLDFRLSKGDGLEFKRHFLKIKKKMDAVVAVQKVLPDT
What is the function of this protein?
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA.  May also negatively regulate cell cycle progression during unperturbed cell cycles.  This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome.  Recognizes the substrate consensus sequence [R-X-X-S/T].  Phosphorylates wee1 at 'Ser-549' and cdc25c at 'Ser-287', which creates binding sites for 14-3-3 proteins which activate wee1 and inhibit cdc25c.  Phosphorylates cdc25a at 'Ser-504' which prevents the interaction of cdc25a with CDK2-cyclin E1, CDC2-cyclin A1 and CDC2-cyclin B1.  This inhibitory effect does not require 14-3-3 protein binding.  Activation of wee1 and inhibition of CDC25 results in increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and consequent inhibition of cell cycle progression.  May promote DNA repair, regulate chromatin assembly and the transcription of genes that regulate cell-cycle progression.  May also play a role in replication fork maintenance.
What are the official names of this protein?
Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Checkpoint kinase-1, xChk1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: NTNM_NECSZ
Sequence: MFGDFVEKLPQKLPQKLDIPLIINVILSIAAIALIRALAISILRQYRLRKLPLVNGVGVFESSQKAKQNFLFNAEGLLENGFTKSTKAFRMATDDSEVLILSPDYIDEIRNDKRLSLTHALAEDFLGHIPAFVNFSPQKGLNDMAGDILQKKLTQSLDLSTEAALALQEQWTDNKEWHALNAKTTMVEIVARISSRVFLGLELCRNPAWLRITADYTVNVFFGVMALKKWPKYLHPFVWRFVPEVRTVRDQIQEAVNLIQPVVEKRTAEGKSPSSRKTYSDTIQWANELANGRPYDPALLQLGFSLAAIHTTSDLLSQILYNICAYPEYIDPLREEIVTVLKEHGMTKAGLFKMKLMDSIMKESQRLKPGAMLMMRRMVLEDITLSNGVFLPRGVQIGIPTRSHFDPSFYTDPERFDGYRYVKMDDDPQREKSRHFVSTSPEHLAFGHGKHACPGRFFASQEIKIALCHILMKYEFKLADGSKPTVMKMGWVLSSDPMVQLMVRKREGVDENLLYK
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the meroterpenoids nectripenoids A and B, as well as cochliquninone D and isocochliquninone E (PubMed:29797385).  The pathway probably begins with the HR-PKS ntnH that catalyzes two chain-extension steps to form a reduced triketide, which then primes the SAT domain in the NR-PKS ntnG to initiate three more cycles of extension to give a linear hexaketide corresponding to the polyketide part of nectripenoids (Probable).  The FAD-dependent monooxygenase ntnJ then performs an oxidative decarboxylation at C11 of the ntnH/ntnG product, via an electrophilic aromatic hydroxylation with concomitant ipso-decarboxylation (Probable).  The membrane-bound polyprenyl transferase ntnF then introduces a farnesyl group before the FAD-dependent monooxygenase ntnK functions as the first epoxidase on terminal C12'-C13' olefin, followed by a second epoxidation on C7'-C8' catalyzed by ntnA (Probable).  The terpene cyclase/mutase ntnI then initiates the sequential tricyclic ring formation through protonation of the terminal epoxide and catalyzes the regioselective and stereoselective 6/6/6-tricyclic ring formation (Probable).  The cytochrome P450 monooxygenase ntnM may then hydroxylate C1' (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase ntnM, Nectripenoid biosynthesis cluster protein M.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YHBY_ECOLI
Sequence: MNLSTKQKQHLKGLAHPLKPVVLLGSNGLTEGVLAEIEQALEHHELIKVKIATEDRETKTLIVEAIVRETGACNVQVIGKTLVLYRPTKERKISLPR
What are the official names of this protein?
RNA-binding protein YhbY.
What are the subcellular locations of this protein?
Cytoplasm. Note=Has been seen to comigrate with the 50S ribosomal subunit in sucrose gradients.
Protein: MUTL_HAEI8
Sequence: MPIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNGCGIPKEELSLALARHATSKIADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEAWQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFAHIDEVIRRIALTKFNTAFTLTHNGKIIRQYRPAEAINQQLKRVAAICGDDFVKNALRIDWKHDDLHLSGWVATPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDVNVHPTKHEVRFHQQRLIHDFIYEGISYALNNQEQLNWHTDQSAVENHEENTVREPQPNYSIRPNRAAAGQNSFAPKYYEKPQQNQPHFSNTPVLPNHVSTGYRDYRSDAPSKTEQRLYAELLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRTLSLIENRALLLQQNQDFFLLSLEKLQRLQWQLALQQIQIEQQPLLIPIVFRLTEAQFQAWQQYSDNFKKIGFEFIENQAQLRLTLNKVPNVLRTQNLQKCLMAMLTRDENSSPFLTALCAQLECKTFDALADALNLLSDTERLLTQTNRTAFTQLLKPVNWQPLLDEI
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: ATPD_PSET1
Sequence: MSELTTIARPYAKAAFELAVEKGTIESWNEMLFFAGHVASNEKASALLAGMPTATTQAELFIQICAEQLNEQGQNLVKVMAENGRLIALPAVAQLFAKFKAEYDKEIDVDVISATPLVAAQQESLVAALEKRFARKVKLNCSEDAAVVGGLIIKAGDTVIDGSIRGKLNRLATTLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YOR2_SCHPO
Sequence: MNDEESHISVLPVMNKQTSLVLQNLKEETENQLKELEKKRSQLHKEEQINLQLVYAINDLRSKTKELKAENEKEDTFLNSFNASGDLTANKKIQLREQSRKLEESLLSYHKKVKEMEKQHRSASSKLELAKLSAQQLQTNVNVLRSQNNPEILQDMISETKDCRSLIAEQLLQSASLLNDFQNDSDRIAKNHSSLIDTSRAHRVSLTNATKNYTHIFDSLLTFTRHDSEDVSTSVEKLTSKKISELEKLFADYCSIEDAFD
What are the official names of this protein?
Uncharacterized protein P8B7.02.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the barrier septum.
Protein: TIG_CLOB6
Sequence: MNVKVENIEKNVVKLEITVDSEKFNEAVKKSFKKNAKRFNVPGFRKGKAPLNIIKKYYGEGVLFEDAINFCCEDTYPKAIEENNIKPVDYPQIDVVQIGEGKDFIYTAEVTTVPEVKLGEYKGVEVKKVSYEVEDEAVENELKSMQEKNARVSLKEEGEIEKGNIAIIDFKGYVDGKAFEGGEAKDYEIEIGSGTFIGDFEDQLVGLKKDESKEVNVSFPEEYGREDLNGKPATFEVTIKDIKVKELPALDDEFAKEVSEFDTLEELKSDIKDRMKKELSEKAKAEYEEAVVEAVAANAEIEIPKVMIEKEIENMVRDLEMRLKYQGLDLKSYYEFTNSSEEKVKEYMRETAEKRVKTDLIMQEIAKVEDIKATEEELKEKAMEVAKQYGQKDIEKTAELIVNAQKAYLEIDIVNGKVLDLLVENSKEIA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: TRUB_PELTS
Sequence: MNGIVNVLKPPGMSSHDVVDRIRRIFGVKKAGHTGTLDPGAAGVLVVCLGVATRLARFLLGEDKEYRVEITFGMSTSTGDSYGEITDQRDASFLKEHDIIRVLPEFTGEVRQVPPMTSAIKWRGKKLYELAREGLVVERQERAVYIKSLEFIRGSGWGTPSPRALMHLSCSKGTYVRSLCHDMGSRLGCGAHMSFLVRTRAGPFKIADSVTLEELQAAASKGVLERKIIEMDRAVSEYPEVIVKSSAVKAVAAGSKLYIPGVARMPLDLDCGKLVRLTGPDGLLAIAEAGREPFDKEKLFFKPVCVLARQAGRSSN
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: OCLN_POTTR
Sequence: MMYEKRSYTGYGHPSSHYDYPPPSGPPGSFYLADVPPQHFYQWRSPPGIVRILQGSVVILCLVIFACVASTLAWEYYGSGGLLGYGGGLGSYYNGYYGGYNGYYYGGLTNPRAANGFMIAMAVLCFLVTLGLVIAGLSKASGARSRRFYLLVAVLSGLLAFVMLIASIVYVVGVNPRAGLGASSGSLYYNQMLMLCNQMMSPVAGGIMNQYLYHYCMVDPQEAVAIVCGFLTVILLCVICYFAQKTRHKIWKYGKPNIFWDKPLATAEGPNVEEWVKNVSGDVGTQDETATLAYSEKPISPLTSAFLPAQENGYGHSTPSSPSVPPPEGPSPPEEKDKGSVSRPPARRGHRQRPRPTGLEESQYETDYTTAAESSGEQNRDDWASLYPPIISDAIRQTYKAEFNNDLQRYKALCAEMDDIGTQLRQLSHELDCLPEGSLRYQGVAEEYNRLKDLKRSPEYQSKKLETQSLRDKLCHIKRMVGGYDQSRS
What is the function of this protein?
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
What are the official names of this protein?
Occludin.
What is the protein family that this protein belongs to?
Belongs to the ELL/occludin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, tight junction.
Protein: REV_HV2NZ
Sequence: MTERADEEGLQRKLRLIRLLHQTNPYPQGPGTASQRRNRRRRWKQRWRQILALADSIYTFPDPPADSPLDRAIQHLQGLTIQDLPDPPTNLPESPESTNSNQRLAEA
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: VIF_VILVK
Sequence: MLSSYRHQKKYKKNKAREIGPQLPLWAWKETAFSINQEPYWYSTIRLQGLMWNKRGHKLMFVKENQGYEYWETSGKQWKMEIRRDLDLIAQINFRNAWQYKSQGEWKTIGVWYESPGDYKGKENQFWFHWRIALCSCNKTRWDIREFMIGKHRWDLCKSCIQGEIVKNTNPRSLQRLALLHLAKDHVFQVMPLWRARRVTVQKFPWCRSPMGYTIPWSLQECWEMESIFE
What are the official names of this protein?
Virion infectivity factor, Q protein.
What is the protein family that this protein belongs to?
Belongs to the ovine/caprine lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion.
Protein: METK_CLAM3
Sequence: MTDLRLFTSESVTEGHPDKICDQISDSILDALLTQDPTSRAAVETLVTTGLVHVAGEVTTSGYVDIPQIVRDRIRDIGYDSSEVGFDGSNCGVTVSIGAQSPDIAQGVDRSYESRSGSASTDAHDLQGAGDQGLMFGYASRDTPVFMPLPIYLAHRLAERLAAVRHSGELAYLRPDGKTQVTIGYEGLVPRTVDTVVLSTQHGPQVSQEDLRREVEEHVIRPVLAAAAEIGIELDSRDATLLINPTGKFEIGGPKGDAGLTGRKIIVDTYGGFSRHGGGAFSGKDPSKVDRSAAYAMRWVAKNAVAAGLADRLEVQVAYAIGKAAPVGLYVETFGTAHVPEERIVRAIRETFDLRPAAIVERLDLLRPIYAQTAAYGHFGRELPDFTWEALDRVADLQSAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_MYCS2
Sequence: MSQDPVIIHTDGGCRPNPGPGGWGAVLRHREHVREMFGGEAAVTSNNRMELTAPIMALEALTRPVTVHLYTDSTYVRNGITKWVLGWERNGWMTAAKQPVKNVDLWQRLQAACARHQVEWFWVKGHSGIGDNELADELATRGLQEAVGLTTSSAGTSLR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBC9_SCHPO
Sequence: MDQAIAGLAAGTASTLIMHPLDLAKIQMQASMNQDSKSLFQVFKSNIGSNGSIRSLYHGLSINVLGSAASWGAYFCIYDFSKRVVMSMTPFNNGEISVLQTLCSSGFAGCIVAALTNPIWVVKSRILSKRVNYTNPFFGFYDLIKNEGLRGCYAGFAPSLLGVSQGALQFMAYEKLKLWKQRRPTSLDYIFMSAASKVFAAVNMYPLLVIRTRLQVMRSPHRSIMNLVLQTWRLQGILGFYKGFLPHLLRVVPQTCITFLVYEQVGMHFKTQSSKSQ
What are the official names of this protein?
Uncharacterized mitochondrial carrier C27B12.09c.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: NBEA_CHICK
Sequence: PKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMATKVSDDVLGSAERPGGGVHVEVHDLLVDIKAERVEATEVKLDDMDLSPETLVTGENGALVEVESLLDNVYSAAVEKLQNSVHGSVGIIKKNEEKDGGPLITLADEKDEPSTNSTSFLFDKIPSQEEKLLPDLSISHISIPNVQDTQMHLGVNDDLGLLAHMTGGVDITSTSSIIEDKEFKIHTNSVGMSSIFERELASLFKGLEYAEMTATTPETEFFCSKTVPNVDAGSIISVTERFVDGKEAGKEIRKIQTTTTTQAVQGRSVTQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTNMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRERVNKTSLISSKAQDALQGVTASAATKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETARSGSQAGRNIRQEINSPTSTETPAVFPENIKDKETPTPVEDIQLESSIPHTDSGIGEEQMPNILNGTDLETSTGPDAMSELLSTLSSEVKKSQESLTESPSEILK
What is the function of this protein?
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane.  May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).
What are the official names of this protein?
Neurobeachin.
What is the protein family that this protein belongs to?
Belongs to the WD repeat neurobeachin family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: GLND_PSEA7
Sequence: MPQVDPELFDRGQFQAELALKSSPIAAFKKAIRQFREVLDNRFNSGRDIRRLIEDRAWCVDQVLQQAWQRFDWGDDADIALIAVGGYGRGELHPYSDVDLLILLDSEDQESFREPIEGFLTLLWDIGLEVGQSVRSVRQCAEEARADLTVITTLMECRTICGPDSLRQRMLEVTGSTRMWPSKEFFLAKRHEQQRRHAKYNDTEYNLEPNVKGSPGGLRDIQTILWMARRQFGSLNLHALVREGFLVESECSMLASSQEFLWRVRYALHMLAGRAEDRLLFDHQRSIARLFGYEDNDVKLAVERFMQKYYRVVMAISELNDLIVQHFEEVILPCEQPVQIQPLNSRFQLRDGYIEVTHPNVFKRTPFALLEIFVLMAQHPEIKGVRADTIRLLRDSRHLIDDEFRHDIRNTSLFIELFKSSQGIHRNLRRMNRYGILGRYLPEFGHIIGQMQHDLFHIYTVDAHTLNLIKHLRKLNRPEMAEKYPLASKIIDRLPKPELIYIAGLYHDIAKGRGGDHSELGAVDAEAFCQSHQLPLWDTQLVSWLVQNHLVMSTTAQRKDLSDPQVIFDFAQLVGDQTHLDYLYVLTVADINATNPTLWNSWRASLLRQLYTETKRALRRGLENPVDREEQIRQTQTAALDQLVRNGIDQDDAEQLWSQLGDDYFLRHTAGDVAWHTEAILQHPDDGTPLVLIKETTQREFESGSQIFIYAADQHDFFAVTVAAMDQLNLSIQDARIITSTSQFTLDTYIVLDADGDSIGNNPERIAEIREGLIDALKNPDDYPTIIQRRVPRQLKHFAFAPQVTISTDALRQVSVLEVIAPDRPGLLARIGGIFLDFDLSVQNAKIATLGERVEDVFYITDARNQPLADPDLCKRLQAALVEQLSQDNGRDTLPTRINF
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: IPYR_SALTY
Sequence: MSLLNVPAGKELPEDIYVVIEIPANADPIKYEVDKESGALFVDRFMSTAMFYPCNYGYINHTLSLDGDPVDVLVPTPYPLQPGAVIRCRPVGVLKMTDESGEDAKLVAVPHTKLSKEYDHIKDVNDLPELLKAQITHFFEHYKDLEKGKWVKVDGWDNAEAAKAEIVASFERAAKK
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YESV_BACSU
Sequence: MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTAAMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSASTNWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCMLIGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG
What are the official names of this protein?
Uncharacterized protein YesV.
Protein: NUOK_PSYA2
Sequence: MVLAASVAQEVANVPFAHEVAGLVQPVAEAQNVLGLIPMSHGLILAGILFAIGLCGVMVRRNFLFMLMSLEIMMNAAALAFVVAGSRWVDPDGQIMFIFILTLAAAEAAIGLAILLRFYHQRGHLDVDSANEMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.