PharMolix/UniProtQA huggingface dataset:
Protein: LPLT_SALTY
Sequence: MSESVRTNTSIWSKGMLSVIVAQFLSAFGDNALLFATLALLKAQFYPDWSQPVLQMVFVGAYILFAPFVGQIADSFAKGRVMMVANGLKLAGAAGICLGINPFVGYTLVGIGAAAYSPAKYGILGELTTGDKLVKANGLMEASTIAAILLGSVAGGVLADWHVIAALVACALAYAGAVAANLFIPKLVAARPGQSWRLSAMTRSFFSACVVLWRNGETRFSLVGTGLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAVGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVAIFSLQHALLPAYALLLLIGMLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGLYSLAVLVGVPAVAIGIGFGVLFALAIAALWIWQRRQASY
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPF_METM5
Sequence: MKFTKMHGLGNDYIYVDAISQKIENPNEISKFVSDRHFGIGSDGLVLILPSDVADFKMRMFNSDGSEAEMCGNAIRCVGKFVYDKKMTDKSTISIETLAGIKVLEMTVENGKVVLVKVDMGEPILKAETIPVLSEKHPVIDEEITAKDYCYNFTCVSMGNPHAITYIENVEEFPLEKIGPLFEVHEKFPKKTNVEFVELIDDSTVKMRVWERGAGETLACGTGACAVLTASVLKGYVGRKATVKLLGGDLIIEWNEKDNHIYMTGPATTVFEGEIDI
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEDD1_BOVIN
Sequence: MQENLRFASSGDDVKIWDASSMTLVDKFNPHTAPHAISSVCWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELGEGQKQTCVSLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDEVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSIRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSTHKAPASGICFSPVNELLFVTVGLDKRIILYDTSSKKLVKTLVADAPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPIKTISAHKTSVQCIAFQYSTVLSKSGLNKGCSNKPTAVNKRTANVSAGGGGAQNPGVVREAATTSIATVPPQPTAAAVGKGAVAPQDKAGLPRSINTDTLSKEAESGKNQDFSNFDDSGKSSLGDMFSPVRDDAVVSKGGDESIGKGDGLDFLPQLNSVFPPRKNPVVSSTSVLHSSPLNVFMGSPGKEENENHDLTAESKKMYLGKQESKDSFKQFAKLISGAETGNLNASPSSNQTRSPEKFEKPEKEIEAQLINEPPGNGSSTPNPKIASSVTAGVAGSLSEKIVDTIGNSRPNAPLSSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHMQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF
What is the function of this protein?
Required for mitosis progression.  Promotes the nucleation of microtubules from the spindle.
What are the official names of this protein?
Protein NEDD1, Neural precursor cell expressed developmentally down-regulated protein 1, NEDD-1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: ISPD_THENN
Sequence: MNVAILLAAGKGERLGEKVPKQFLEVEGRMLFEYPLKALLDSNVIDAVVIVVSRDWMDRVVEKVKHEKILGIVEGGKTRSQSVRNALKFLENIKPSYVLVHDAARPFLRKKHIEEVLKKAQETGAATLALKNSDTLIRLDDSRIEYVPREGIYRVQTPQAFSYDLLKRAHSEEKEWADDTEPVHRLGVKISVVEGDLFCFKVTFKSDLELARLIAKEWERIA
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: PRSA_GEOSW
Sequence: MRKWMIVAAVAAVFGLSACNNGDSEVIVKTKDGNITKEEFYNEMKARVGKEVIRDLVHEKVLSKKYKVTDKEIDKEIENLKEMYGTQYDLVVQQNGEKAIRDMVKLDLLRQKAAMEDIKVTDKELKDYYKNYKPKIRASHILVKDEKTAEEIKTKLDKGEDFAKLAKQYSQDPGSAPNGGDLGWFGPGKMVKEFEDAAYKLKVGQVSDPVKTDYGYHIIKVTDKEEKKPFNEMKEEIEFEVKQSKLDPAKVQSKVEKLIKDAKVEIEDKDLQDVLK
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: LAX13_ORYSJ
Sequence: MASGSSGGGYADEKGPGAATMQALGLQQQHGGGGEVEEESSEMGEKTAARTRLSGLLWHGGSAYDAWFSCASNQVAQVLLTLPYSFAQLGMASGLLFQLFYGLLGSWTAYLISILYLEYRTRKERDKVDFRNHVIQWFEVLDGLLGRHWRNVGLAFNCTFLLFGSVIQLIGCASNIYYINDHLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLLMTTYTAWYIAVASLIHGQVEGVAHSGPTSIVLYFTGATNILYTFGGHAVTVEIMHAMWRPQKFKAIYLLATVYVLTLTLPSASAAYWAFGDALLTHSNALALLPRTPWRDAAVVLMLIHQFITFGFACTPLYFVWEKLVGLHGCPSLCKRAAARLPVVLPIWFLAIIFPFFGPINSAVGSLLVSFTVYIIPSLAYMVTFRSPQSRQNAVERPPRFAGGWTGAYVINSFVVAWVLVVGFGFGGWASITNFVHQVDTFGLFAKCYQCPPHPAAAALSPPGAIAPAPASMLPPFNSTAAGIFAAPVPSPAPAPAPMHFVLGHHHHHRHHRHGL
What is the function of this protein?
Carrier protein involved in proton-driven auxin influx.  May mediate the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips (By similarity).
What are the official names of this protein?
Auxin transporter-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.1) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: METAS_PSET1
Sequence: MPITVKDELPAIARLRQENVFVMPQTRAKTQEIRPMRLAILNLMPNKVETEVQFIRLLANSPLQVNVELLRLDTHRSSSNSEQHLDTFYRYFSEVKNNNYDALIVTGAPLAHLEYQDVAYWDEFTAILDWAEQHVTSTLFSCWAAHAALYHHYKIKRDLKTDKLCGVFTHQCYFEHGALTRGFDDTFLVPHSRYGHVDVNKINACNELVVLAGSEKVGAYLVKNKSGSQVFITGHPEYDADSLKAEYQRDCEKSDNAPKPENYFPDDDATKQPSKTWQSHAFLLFSNWLNYYVYQTTPYDINLVSQDVRTNNYAE
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_RHILO
Sequence: MSRPEVVNSVAALRAQVSDWRRDGLRVAMVPTMGALHEGHLSLIRIAREKAERCVVSIFVNPTQFAPSEDLDKYPRQLARDLDLLARVKADLAFTPTVGAMYPAGFATRISVGGPSAGLESDFRPTFFEGVATVVAKLFLQATPDCAVFGEKDYQQLCVVRQLCRDLDLPVEIIGAPTIRDAHGLAMSSRNAYLDEAELAVARRLNVILHKAAAALAAGTHQDDATGEANRALIAAGFQKIDYVEARESLTLAPWRRDRAGRVLAAAWLGKTRLIDNVDVPVA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_NITHX
Sequence: MTARVCVARIGAAHGLRGEVRLWTFTEDPIAVTRYGSLSTKDGARQFEVTHAREVKDYLVATLTGVTTREEAERLNGTDLYVARDKLPATDEGEFYHADLIGLAAVDVAGKPLGTVAAIHNFGAGDIIEIAPAHGPTLMLPFTDAVVPTVDIAGGRVVIEMPGEIDGDTPDQA
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3S11_OXYSC
Sequence: MKTLLLTLVVVTIVCLDLGYTMTCYNQQSSEAKTTTTCSGGVSSCYKKTWSDGRGTIIERGCGCPSVKKGIERICCRTDKCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin 1, SNTX-1, Toxin 3.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HUTU_BACCZ
Sequence: MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGSLKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNAAEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGASWVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYCM_RICPR
Sequence: MTGKELNKIVAAILFASLIAMIVGFIANILYKPNLHVLHRGYSIAIQKSSSNESATVIAQESVNIQELMKTANANHGREIAKKCLMCHSLDKDGPNKLGPHLWNIVGRPKASITDYKYSFAISKLGGVWDDENLFAFLHKPSSYAPGTKMSFAGISKPQDIADVILFLKNYVHDQ
What is the function of this protein?
May be involved in electron transfer from bc1 complex to aa3.
What are the official names of this protein?
Cytochrome c homolog.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: UNG_STAA9
Sequence: MEWSQIFHDITTKHDFKAMHDFLEKEYSTAIVYPDRENIYQAFDLTPFENIKVVILGQDPYHGPNQAHGLAFSVQPNAKFPPSLRNMYKELADDIGCVRQTPHLQDWAREGVLLLNTVLTVRQGEANSHRDIGWETFTDEIIKAVSDYKEHVVFILWGKPAQQKIKLIDTSKHCIIKSVHPSPLSAYRGFFGSKPYSKANAYLESVGKSPINWCESEA
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_BUCAP
Sequence: MNFDITRYPILSFAHSVRRLRLLSIEQLPQLCTELRKYLLDVVSITQGHFASGLGVIEITVALHYVYDTPFDNLLWDVGHQSYPHKILTGRAEKIGSIRKKNGLHPFPFREESKYDILSVGHSSTSISAGLGLSIAAGKEGKNRKTICVVGDGSMTAGMAFEAMNHAGIIQSDLLVVLNDNQMSISKNIGALNKHLKFLRDIKKSSKIFNFSIFESLNFKYLGPFDGHNIFKLIEIFKKTKDYRKTCLLHLITKKGKGYLPAELDPIKWHTISQSFSSSSKILTYSDVFGSWLCEIAEFDKKIMAITPAMCEGSGMLKFSRLFPNQYFDVAIAEQHAVTFAAGLAIAGYKPVVSIYSTFLQRAYDQIIHDVALQKLPVLFAIDRGGIVGHDGPTHQGIFDLSYLRCIPGIVIMTPSNENECRQMLYTGYMYKEGPSVVRYPKGKGIGMSLSPMKLIPLGKSLIKRVGEKIAILNFGALLQNAYLAAEKLNATLIDMRFVKPLDTNMILKLSLKYNFLVTIEEGVIAGGAGSAVNEFIMMRKILLPVLNIGLPDMFIAHGSQEEIKHDYQLDPEGIQNKILAWLSY
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: ANM6_BOVIN
Sequence: MSQPKRRKLESGGGGEGGEGTEEEDGGELEVAVPRPRRTRRERDQLYYQCYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASDIWQQAREVVRLNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGCGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLELRLSFWSQMKQLYGVDMSCLESFATRCLMGHSEIVVQGLSGEDVLARPQCFARLELARAGLEQELEAGVGGRFRFSCYGSAPMHGFAIWFQVTFPGGDSEKPVVLSTSPFHPVTHWKQALLYLNEPVQVEQDTDVSGEITLLPSQDHHRHLRVLLRYKVGDQEEKTKDFAMED
What is the function of this protein?
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA.  Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates.  Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a.  H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3).  Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (By similarity).  Repression of TP53 blocks cellular senescence (By similarity).  Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively).  Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity.  Methylates HMGA1.  Regulates alternative splicing events.  Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1.  Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator.  Methylates GPS2, protecting GPS2 from ubiquitination and degradation.  Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity).
What are the official names of this protein?
Protein arginine N-methyltransferase 6, Histone-arginine N-methyltransferase PRMT6.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR8_EPIVI
Sequence: MGRDTILEIINSIRNADRGRKRVVRITSTNITENFVKILFIEGFIENARKHREKNKYYFTLTLRHRRNSKRPYINILNLKRISRPGLRIYSNSQQIPLILGGIGIVILYTSRGIMTDREARLKGIGGELLCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, plastid.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid.
Protein: SYT_HAEIE
Sequence: MPIITLPDGSQRQFDHPVSVLEVAQDIGAGLAKATIAGRVNGERRDACDVIEQDATLEIITAKDEDGLEIIRHSCAHLLGHAIKQLFPDVKMAIGPTIENGFYYDVDLDRSLTQEDIDAIEKRMLELAKTNYDVVKKRVTWQEARDTFEKRGEPYKMAILDENIERTATPALYHHLEYIDMCRGPHVPNMRFCQHFKLQKVAGAYWRGDSKNKMLQRIYGTAWADKKQLAEYLTRLEEAAKRDHRKIGKALDLYHMQEEAPGMVFWHNDGWTIFRELETFVRTKLKQYDYQEVKGPFMMDRVLWEKTGHWQNYADLMFTTQSENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQIESEVTSCIKMVYDIYSTFGFTNIAVKLSTRPENRIGSDEMWDRAEAGLAAALAHNGLEYEIQEGEGAFYGPKIEFALRDCLGREWQCGTVQLDFALPGRLDATYVAEDNSRKTPVMIHRAILGSIERFIGIITEEYAGFFPAWLAPTQAVVMNITDSQSDYVQQVVKTLSDAGLRVKADLRNEKVGFKIREHTLRRVPYMLVCGDKEIAEGKVAVRTRKGADLGTFTVEEFAEILKNQVRSRELKLLNEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1197_ARATH
Sequence: MAQELDLELGLAPYDPWVLKKNLTESDLNNGFIILPKQDFEKIIRQMERGLVKNLGNGVEVKVHIIEEGPESDDYTLTLVKCRGNCMFRGGWYNMVKAKCYKPDDEIGLMWDKWSRRFLFHHIN
What are the official names of this protein?
Putative B3 domain-containing protein At1g51970.
What are the subcellular locations of this protein?
Nucleus.
Protein: GMHA_BUCAI
Sequence: MYKKIIFSEFNSASKILKNFLEDKKQIENIQKAAILIAQSFKNEKKVISCGNGGSHCDAVHFSEELTSVYRKKRSGYPAISISDSSYISAVGNDFGYDQIFSRFIQSVGHLGDILLAISTSGNSLNIVRAIEEAKKKKMKVIVLTGNNAGKIKNLSDIEICIPHCGYSDRIQEMHIKIIHILILIIEKEMQKN
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCNJ1_HUMAN
Sequence: MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
What is the function of this protein?
In the kidney, probably plays a major role in potassium homeostasis.  Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.  This channel is activated by internal ATP and can be blocked by external barium.
What are the official names of this protein?
ATP-sensitive inward rectifier potassium channel 1, ATP-regulated potassium channel ROM-K, Inward rectifier K(+) channel Kir1.1, Potassium channel, inwardly rectifying subfamily J member 1.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily.
Protein: RUVA_BRUAB
Sequence: MIGKLKGVIDEIAEDHAVIDVHGVGYVAFCSARTLGNLGGAGEAAILFIETYVREDMIRLYGFATQLEREWFRLLQNVQGVGAKVALAVLGTLSPSELANAIALRDIAMVSRAPGVGKKVAERIVTELKNKAPAFAGEASGTIGLKQELGAGAAPAPVADAVSALSNLGYSRDQAANAVAAALKETGEGADSAKLIRLGLKELSQ
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: LPLA_ECOBW
Sequence: MSTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTSIVLNALNALGVSAEASGRNDLVVKTVEGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITSVRSRVTNLTELLPGITHEQVCEAITEAFFAHYGERVEAEIISPNKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGHITRAQVFTDSLNPAPLEALAGRLQGCLYRADMLQQECEALLVDFPEQEKELRELSAWMAGAVR
What is the function of this protein?
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
What are the official names of this protein?
Lipoate-protein ligase A, Lipoate--protein ligase.
What is the protein family that this protein belongs to?
Belongs to the LplA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRR_STAAC
Sequence: MDKETNDNEYRRQSEHRTSAPKRKKKKKIRKLPIILLIVVILLIALVVYIVHSYNSGVEYAKKHAKDVKVHQFNGPVKNDGKISILVLGADKAQGGQSRTDSIMVVQYDFINKKMKMMSVMRDIYADIPGYGKHKINSAYALGGPELLRKTLDKNLGINPEYYAVVDFTGFEKMIDELMPEGVPINVEKDMSKNIGVSLKKGNHRLNGKELLGYARFRHDPEGDFGRVRRQQQVMQTLKKEMVNFRTVVKLPKVAGILRGYVNTNIPDSGIFQTGLSFGIRGEKDVKSLTVPIKNSYEDVNTNTDGSALQINKNTNKQAIKDFLDED
What is the function of this protein?
Involved in SarA attenuation.  Affects resistance to oxacillin and teicoplanin, as well as the synthesis of virulence factors (By similarity).
What are the official names of this protein?
Regulatory protein MsrR.
What is the protein family that this protein belongs to?
Belongs to the LytR/CpsA/Psr (LCP) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: RNZ_STAEQ
Sequence: MEVTFFGTSAGLPTKERNTQSIALNLEPYSNSIWLFDVGEGTQHQILRHSIKLGKIDHIFITHMHGDHIFGLPGLLTSRSFQGGENKPLTIIGPKGIQNYIETSLQLSESHLNYPITYIEINQQLAYHHNGFTVQAEMLNHGIPSFGYRIEAPITPGTINVEALRGIGLEPGPKYQEVKLQETFEYKGLIYNSDDFKGKAKPGPIISIFGDTKPCENEYELAKNSDLMIHEATYIEGDKKLANNYHHSHIDDVFNLIKQANVNKSLITHISNRYNIDEVTSIYNELSLDQTSPHFYFVKDFDTFKI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: LIGO2_HUMAN
Sequence: MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI
What are the official names of this protein?
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2, Leucine-rich repeat neuronal protein 3, Leucine-rich repeat neuronal protein 6C.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RS21_SHIBS
Sequence: MPVIKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTTERKRAKASAVKRHAKKLARENARRTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: DNLJ_MYCMM
Sequence: MTPEVLRQWQELAEQVREHQFRYYVRDAPVITDAEFDELLRRLEALEEQYPELRTPDSPTQLVGGAGFATEFEPVEHLERMLSLDNAFNTEELTAWAGRIHADVGDSAAYLCELKIDGVALSLVYEGGRLTRASTRGDGRTGEDVTLNARTIEDVPERLSHSEDHRMPEVLEVRGEVFFRVADFQALNASLVEEGKAPFANPRNSAAGSLRQKDPAVTARRRLRMICHGLGHTEGFRPATLHQAYLALQAWGLPVSQHTTLVADLAGVQERIDYWGEHRHEVDHEIDGVVVKVDDVALQRRLGSTSRAPRWAIAYKYPPEEAQTKLLDIRVNVGRTGRVTPFAFMTPVKVAGSTVAQATLHNASEVKRKGVLIGDTVVIRKAGDVIPEVLGPVVDLRDGSEREFVMPTTCPECGTPLAPEKEGDADIRCPNTRSCPGQLRERVFHVSSRNALDIEMLGYEAGAALLSARVIGDEGDLFGLTEEELLRTDLFRTKAGDLSANGRRLLANLDKAKAAPLWRVLVALSIRHVGPTAARALATEFGSIDAIVSATTEQLAAVEGVGPTIASAVSEWFTVDWHREIVEKWRAAGVRMADERDDSVPRTLAGVTVVVTGSLPGFSRDEAKEAIVTRGGKAAGSVSKKTSYVVAGDAPGSKYDKAVELGVPILDEDGFRKLLEQGPPAEVGEPT
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.