PharMolix/UniProtQA huggingface dataset:
Protein: U2AF4_HUMAN
Sequence: MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQTIVLLNLYRNPQNTAQTADGSHCHVSDVEVQEHYDSFFEEVFTELQEKYGEIEEMNVCDNLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGELSPVTDFRESCCRQYEMGECTRGGFCNFMHLRPISQNLQRQLYGRGPRRRSPPRFHTGHHPRERNHRCSPDHWHGRF
What is the function of this protein?
RNA-binding protein that function as a pre-mRNA splicing factor.  Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection.  Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts.  Also participates in the regulation of alternative pre-mRNA splicing.  Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1.  Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity).  Shows a preference for AGC or AGA (By similarity).
What are the official names of this protein?
Splicing factor U2AF 26 kDa subunit, U2 auxiliary factor 26, U2 small nuclear RNA auxiliary factor 1-like protein 4, U2AF1-like 4, U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3, U2 small nuclear RNA auxiliary factor 1-like protein 3, U2AF1-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling.
Protein: SEPF_CLOPS
Sequence: MSKVVSKMKSFLGFDEFEDEDEVMEEEEVMEEEESFAPVLSSKKNGKVVNIHTANTAKLMITKPLVYDDATEICTALKNRKIVVINTTSLELRTAQRLIDFVGGACYALCGELQEVEKGVFIVSPSNVEVSNELKSELSNKGMFNWASK
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RS2_LISIN
Sequence: MPVISMKQLLEAGVHFGHQTRRWNPKMKKYIFTERNGIYIIDLQKTVKKVDEAFNFMREVASDNGTILFVGTKKQAQESVRDEAIRSGQYFVNHRWLGGTLTNFETIQKRIQHLKKIEKMEADGTFEVLPKKEVVLLKKEQEKLERFLGGIKDMKGLPDALFIVDPRKERIAVAEARKLHIPIIGIVDTNCDPDEIDYVIPANDDAIRAVKLLTAKMADAIIEVNQGEELTEAEVAPVEEKAAEETTEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PLIGB_GLOBS
Sequence: MKSFLFCCLLGTFLAIGMCLECEVCMQPGKRCNGSMMTCKDNEDTCVMFQTEVIRAPLSFTFTSKMCSTSDTCHLDYVETNLPYELAVRSRRACCVGDECKTMPPVVLEHHDNRYNGLHCPGCIGFGSHECNEKLVSCRDTENQCLSLIGKNFDFVADDITIKGCATESLCSLLQKKIFSAIGEFDLDVKCTPVFPQSSQ
What is the function of this protein?
Inhibits the enzymatic activity of phospholipase A2 (PA2).
What are the official names of this protein?
Phospholipase A2 inhibitor gamma subunit B, gamma-PLI B, PLI-gamma, Phospholipase A2 inhibitor gamma 20 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the CNF-like-inhibitor family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in blood plasma.
Protein: CHI_PINMA
Sequence: MYLTIWLVSILALGTWGQKFNRFCHYNSWALSRNPQHGLVPEDIDPFLCTHLILGFAEIDESGLRLKDPNHYQQEYLYQRIVRLRRINPRLNMILSVGGWDKSQEGYSKLVSSRENILFFTKWIITYLRRHDFDGLDLDWEYPTFKGSPMGDKKKFVDLVENLAYEFDIEEIPDIKWKLTLTWTADPLESVRTSAYDIKGIASKVHNVNLKMYDFHGHWDDPLQVNHHSPLTSPNSPRNVNELAKSWVKAGVRIEKLILGIPFFGRSFTLKTANMSVPGSPAVGPGSDFGDGIPIHNLCHIIRGGTKELYLPEKKVPYIVSGSEWIGYDNPRSVMEKAQLVFNNALAGVMIYSLDMDDHHGTCGRKWPMMMAVIHGLNAYMEYIDSKHKSLELTFNKKILRARVSLRNYRRRNQQEKVAEMEQRIRHLEQELQQSMGNMAYERQQAQAMLNRGVSLPPIEQQSWSW
What are the official names of this protein?
Putative chitinase, Chitinase-like protein 3, Clp3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SOSCB_DROWI
Sequence: MAFPNTSAQQAETNRKILEEIQTKKQLLAGGIINLGLSNTNQMPAPQLLGQPTTTTATPDLVSTNSTPPRAAFNPTSSTTLGFFIPQDSYFGNSLIPVLPRLELPATPSTTTPPITPIANANNPK
What are the official names of this protein?
SOSS complex subunit C homolog B.
What is the protein family that this protein belongs to?
Belongs to the SOSS-C family.
Protein: GPDA_YERP3
Sequence: MNTNPASMAVIGAGSYGTALAITLARNGHQVVLWGHDPKHIQQLQQDRCNRAFLPDAAFPDTLRLETDLACALAASRDVLVVVPSHVFGAVLHQLKPHLRKDARIVWATKGLEAETGRLLQDVAREVLGEAIPLAVISGPTFAKELAAGLPTAIALASTDVQFSEDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMTRLGTALGADPSTFMGMAGLGDLVLTCTDNQSRNRRFGIMLGQGLGVKEAQDNIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKNAREAALTLLGRTKKDEKIGI
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_SHEFN
Sequence: MNPIVKSFEYGQHTVTLETGVIARQADAAVLASMGDTTVLVTVVGKKVADLSRDFFPLTVNYQEKTYAAGKIPGGFFKREGRPSEDETLIARLIDRPIRPLFPNGFKNEVQVIITVVSVDPQIEPDIVSMIGTSAALAISGIPFSGPLGAARVGYINDEYVLNPTVDQLATSSLNLVVAGTKAAVLMVESEAKALAEEIMLGAVTYGHDQQQVVVDAIAEFKAEAGKPTWDWTAPVQDQALVAKIKELAEAGMTEAYQIEVKQDRYVQVGIVKAAAKAALVAENPDVDTREVDNLLGSLEKSVVRGRIISGKPRIDGREPDMIRALSVLAGVLPRTHGSSLFTRGETQALVTCTLGTERDAQKIDSIMGERTNRFMLHYNFPPYSVGETGMVGSPKRREIGHGKLAWRGMNAVMPSAEEFPYSIRVVSEITESNGSSSMASVCGTSLALMDAGVPIKTSVAGIAMGLVKEGDDFVVLSDILGDEDHLGDMDFKVAGTRDGITALQMDIKIEGITKEIMDIALQQAYGARVHILNVMDQAIGTHRGDISAHAPRITTIKINPEKIRDVIGKGGAVIRALTEETGTTIELDDNGTVKIASSNGEATKEAIRRIEEITAEVEVGRIYNGKVIRIVDFGAFVNILPGKDGLVHISQISDERVANVSDHLEMNQEVAVKVMEVDRQGRVRLSIKEAQAKETAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSF2R_MOUSE
Sequence: MTSSHAMNITPLAQLALLFSTLLLPGTQALLAPTTPDAGSALNLTFDPWTRTLTWACDTAAGNVTVTSCTVTSREAGIHRRVSPFGCRCWFRRMMALHHGVTLDVNGTVGGAAAHWRLSFVNEGAAGSGAENLTCEIRAARFLSCAWREGPAAPADVRYSLRVLNSTGHDVARCMADPGDDVITQCIANDLSLLGSEAYLVVTGRSGAGPVRFLDDVVATKALERLGPPRDVTASCNSSHCTVSWAPPSTWASLTARDFQFEVQWQSAEPGSTPRKVLVVEETRLAFPSPAPHGGHKVKVRAGDTRMKHWGEWSPAHPLEAEDTRVPGALLYAVTACAVLLCALALGVTCRRFEVTRRLFPPIPGIRDKVSDDVRVNPETLRKDLLQP
What is the function of this protein?
Low affinity receptor for granulocyte-macrophage colony-stimulating factor.  Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
What are the official names of this protein?
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, GMCSFR-alpha, GMR-alpha.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 5 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: BIOF_ECO55
Sequence: MSWQEKINAALDARRAADALRRRYPVAQGAGRWLVADDRQYLNFSSNDYLGLSHHPQIIRAWQQGAEQFGVGSGGSGHVSGYSVAHQALEEELAEWLGYSRALLFISGFAANQAVIAAMMAKEDRIVADRLSHASLLEAASLSPSQLRRFVHNDVTHLARLLASPCPGQQLVVTEGVFSMDGDIAPLAEIQQVTQQHNGWLMVDDAHGTGVIGEQGRGSCWLQKVKPELLVVTFGKGFGVSGAAVLCSSTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRRDEGDARREKLVSLIARFRAGVQDLPFTLADSCSAIQPLIVGDNSRALQLAEKLRQQGCWVTAIRPPTVPAGTARLRLTLTAAHEMQDIDRLLEVLHGNG
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: KV502_HUMAN
Sequence: MGSQVHLLSFLLLWISDTRAETTLTQSPAFMSATPGDKVNISCKASQDIDDDMNWYQQKPGEAAIFIIQEATTLVPGIPPRFSGSGYGTDFTLTINNIESEDAAYYFCLQHDNFP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 5-2, Ig kappa chain V region EV15.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: PAT_STRCO
Sequence: MPGTAEVQVRPGVEEDLKPLTDLYNHYVRETPITFDTEPFTPEERRPWLLSHPEDGPYRLRVATDAESQEILGYATSSPYRAKPAYATSVETTVYVAPGAGGRGIGSLLYASLFDALAAEDLHRAYAGIAQPNEASARLHARFGFRHVGTYREVGRKFGRYWDVAWYERPL
What is the function of this protein?
Inactivates phosphinothricin (PPT) by transfer of an acetyl group from acetyl CoA.  The physiological substrate could be a structurally related compound.
What are the official names of this protein?
Phosphinothricin N-acetyltransferase, PPT N-acetyltransferase, Phosphinothricin-resistance protein.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. PAT/BAR subfamily.
Protein: FADI_SALPB
Sequence: MRQALPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVGELLARSEIPADAIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKALARVLVDGNKARTTRQRLTLFSRLRLRDLLPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAHRSHQRAAQAWAEGKLAEEVMTTYVPPYKNPFAEDNNIRGASTLADYAKLRPAFDRKHGSVTAANSTPLTDGAAAVIMMTESRAKELGLRPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMADLTLFDMHEAFAAQTLANLQLLGSERFAREVLGRAQATGEVDDAKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVTACAAGGLGAAMVLEAE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCAL1_LAGLA
Sequence: MDKPRQENEEEPQSAPKTNEERPSVEHSPEKQSPEEQSSEEQSSEEEFFPEELLPELLPEMLLSEERPPQERLSRKDLFEGRPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLTNEEMIQAADELEEMKRVRNKLMIMHWKAKRSRPYPI
What is the function of this protein?
May be involved in transcriptional regulation.  Modulates various viral and cellular promoters in a promoter context-dependent manner.  Does not bind DNA directly (By similarity).
What are the official names of this protein?
Transcription elongation factor A protein-like 1, TCEA-like protein 1, Transcription elongation factor S-II protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family. TFA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECA2_CHLCH
Sequence: MIPSQEYRKSVVHQPENVPSGFRGATHWLAGKVHRRQSKQQALLEQAHTIHTAAEAHRTLSLVDLQAQLLSFRDHFRRRARGYEQHISAAMALIVEASHRQLGLRPFPVQIMGALALLEGSLIEMQTGEGKTLVAALAAVFLGWSGRSCHVITVNDYLASRDYARLEPLYTFCGVTASCVIGELKRPERQRSYQAAVVYVTSKELVADFLKDRLLLHGVSDPSRHFLHSSNTLREGDEVPVLNGLWAAIVDEADSVLVDDAATPLIISRPVKNEPLMEACREAVRLAAKLQPTLHYTVEERYKQIALTSEGNATIEQMLPTLPPFWHSATRRNELLLLVLNAREFFRKGKDYVVSDGKVVIIDEFTGRLMPDRKWQKGTQQIVELLEGVEPTDPVEVAARISFQRFFRFYKLLCGMSGTVKGVTAELWHIYSLPYVAIPTNKPSRRTTQAPEYFLEKGAKYAALIATLEALHRQGVPILVGTRSVRESEFLADLLRQKMLNFQLLNAIYHKEEAAIIARAGERGNITIATNMAGRGTDILLEQGVAALGGLHVLLAEPNEAERIDRQFYGRCARQGDPGTSYSYIALDDRLLQRFFPERFLNSVMAEVLLRRLPGSHALMQLLVYLAQQMAQRMAYQQRLSLLRRDEQLDQLMSFAGSGPKF
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 2.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: TPPC9_MOUSE
Sequence: MSVPDYMQCAEDHQTLLVVVQAVGIVSEENFFRIYKRICSVSQLSVRDTQRALFIRYRHHYPPENNEWGDFQTHRKVVGLITITDCFSPKDWPQTFEKFHVQKEIYGSTLYDSRLFVFGLQGDVAEQPRPDVAFYPNYDDCDSVEKRIEDFIESLFIVLESKRLDRATDKSGDKIPLLCVPFEKKDFVGLDTDSRHYKKRCQGRMRKHVGDLCLQAGMLQDALVHYHMSVELLRSVNDFLWLGAALEGLCSASVIYHYPGGTGGKTGARRLQGSSLPSEAANRHRPGAQEVLIDPGALTTNGINPDTSTEIGRAKNCLSPEDIIDKYKEAISYYSKYKNAGVIELEACVKAVRVLAIQKRGMEASEFLQNAVYINLRQLSEEEKIQRYSILSELYELIGFHRKSAFFKRVAAMQCVAPSIAEPGWRACYKLLLETLPGYSLSLDPKDFSKGTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFLSDQEKKDVTQSLENYTAKCPGTMEPITLPDGLTLPPVPFTKLPIVRCVKLLSLPTSLRPHKVKSLLGQSMSTKSPFIYSPIIAHNRGEERNKKIDFQWVQGDVCEVQLMVYNPMPFELRVENMGLLTSGVEFESLPAALSLPAESGLYPVTLVGVPQTTGMITVNGYHTTVFGVFSDCLLDNLPGLKTGGSTVEVIPALPRLQISTSLPRSARSLQPSAGDEIATNVSVQLYNGETQQLAVTLENIGLEPLEQLEVTSKLLTTKEKLYGDFLSWKLEETLAQFPLQPGKVATFTINIKAKLDFSCQENLLQDLSDDGISVSGFPLSSPFRQVVRPRVESRPTNPSEGSKTGDLGHVKTLEAVLNFKYSGGPGHVEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVCARNNSELVLHASECQRMAIQVDKFNFESVPESPGEKGHFANLKQLEEERQEARGLEISSKLDIRWRIPSLKRSGEASVEGLLNQLILEHLQLAPLQWDVLVDGQPCDCEVAAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDVISFVGSSTFYLDTVQPSGQSTCLGALLFLYTGDFFLNIRFHEDCKSKELPPSWVCLPSVHVRALGAQA
What is the function of this protein?
Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex.  May function in neuronal cells differentiation.  May play a role in vesicular transport from endoplasmic reticulum to Golgi.
What are the official names of this protein?
Trafficking protein particle complex subunit 9, NIK- and IKBKB-binding protein.
What is the protein family that this protein belongs to?
Belongs to the NIBP family.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cytoplasm. Note=Processes and cell bodies of neurons.
Protein: SEC16_ASPOR
Sequence: MAHNEVSAAWHPALRSEDGVPSNAPVSDDLTQVSKDSMTESAAELKPSEAVIQENDLHSSSTSPDTDASVNVQSTAVPAVLDSDTPVYAEQVLNQENAQKNTAENSAQEDAPDHGQELSQTISDEPHVIETSEESAPTLGAAFGSDANGSHDTAAPDYMMDEPSPAEHDTTERREDNDAASWFNEQVDSGDRQTTNEFVNDDNQDFWGSPTNGDAGDDFFNQLKTQTKPIYIPPETESRYEEGVPLLDNTVESPVQPSMKEESQIDKIFEDDGDDEGGAFFNEVQGSVPNEGVPSPPITRKSTTQVIGSLDASPDSPVSPASSTAQEFNNILAAAASENQVKEDLSDDDLAAKWQAELSDDQPEKSTEDDLAARWQAALDDDDDLLLEDEIGKGPNNGQESLPQNPNGSVHETTQATLSSPFGTPQSSARPQAQPTSYTPHQPSTSDLLQGIPGIAPQSSAAPMQDYFAPPAQPRPTTKRAESFAERSKEGYKSPYDLPDDLTRPRKPVVTHKPVVAQPGSMPPPPRSSSIPVPPTNAPGVPTPPPAPSTVPAVTTPKNFYEELPLPPPRPRSRPASSGRYTPTANIVTSPPSHSQPPPPPPANPYASLSPPPQDSGSVGSQTQLQQPERLDPYANLLGPGAPGAPAAPSAASRYSPKPPTLQPGTKPPSAPRYSPAPPQSAAPAPPRTRYASQPSSVSSQGAVLPFQPRTSSPLAHHEKVSYQPPEGLAIRSAPESASSYAPNGMQPRPNQQDVSNSITAPVGAAGSAAVTAVPENVSAAIQPTSPPRNPYAPPAYINEFSKRVAPMASPPPAVVPPTGDAQFVPPRRSQTQSPSQQASAPGLSVPSDSLQRPASVHAPASPTKSANPYAPSQISIHNRVPSQPLEFIPPNDGQELDPLERWKGAPIVKFGFGGSITSCFPKHVPRYAAGQAAPKIKSTPGEVKIFSANDWVPITEGIVQHPGPLKNKSKKKDLVAWLSSKIAAFENEGISEAAQLHPESSKRHDEKILLWKIVRALVEHDGVLEGSAEVEKSLRYIIFPHLQNSEPESTSGVNLPAFNALPPLNAPSQSDATDSQSLESIRNSLLVGNREKAVWDAVDNRLWGHAMVIASTLDRSVWKQVVQEFVRREVKSTTGNSESLAALYEIFAGNVDESVDELVPPSARAGFQMVSKVGGQGPSKNALEGLDSWRDTLGLVLSNRSPEDHKALLALGRLLLSYGRTEAAHICFMFSRAAVFGGADDPQTSIVLLGADHQHLPLNVLQDDDAILLTEAYEYAVSVLAGSPTSTLPHLLAFKLIHACSLAEHGRKSEALQYVDAITAALNATTKPSGYHNQHLLFGVDELSARLRQTTSDSGSSWISRPSMEKVSGSMWAKFNSFVAGEDSDAASTGSGKAGDGDIGPFAKFSGTPTVSRSPSVSDFGPYSLPAAQSVPGSGPSRYQPGNQYVPNSSPEQYRGRSSLDSQRSSSFGFPFGQRRGSQEPSTPVESSMYQGGPLYGSPSAAGYQSTPPQASYMPLAPVVEDSAPQPYPVEPAPMQGSPVNISPYQPPANESFGEPLDQSSATVPASSMAGYVPPGAGGGYEPPSVEISAAPALDTTEEPTHQDVLKKKKSFMDDDDDDDLAARAAAIQKAEKARKDREADEAFRKAAEADAKRPPAAKKSWFGGWFGGAKKENDNNNNSGGPIRAKLGEENSFYYDKELKKWVNKKDPNSASVSRGTPPPPKASAPSRSASGSTAPPAASMGLGLDSRPPSSAGAPPSLSSSPAPPSLAAPPPMLGTARSASTSAAMPTPPIGSSLPPPPRPATSLSNASSIDDLLGAPQARKGTSAKGRKKGRYVDVMAK
What is the function of this protein?
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules.  Also involved in autophagy (By similarity).
What are the official names of this protein?
COPII coat assembly protein sec16, Protein transport protein sec16.
What is the protein family that this protein belongs to?
Belongs to the SEC16 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BTB7_MYCS2
Sequence: MAEDVRAEIVASVLEVVVHEGDQIGEGDTLVLLESMKMEIPVLAEVAGTVTKVNVAEGDVIQAGHLIAVID
What are the official names of this protein?
Biotinylated protein TB7.3 homolog.
Protein: HRG1_CAEEL
Sequence: MHQIYSSDVSSITSKSSIAKAEIITMEEEQQRQSCCTWFHSLKVQIWIAWLGVSAGVMAGTVFAIQYQNWIAVTMCFISSGFATLVLHLHLAYKKTQMAGWSETRLRCLAAVGATVSFLSFIAMVFCLVVAGIEHQTLDKQGLMGANLWIAAVWFFMTSKWSALTWRFARKYRAFCEESQPLLAAAPPEYSVTI
What is the function of this protein?
Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
What are the official names of this protein?
Heme transporter hrg-1, Heme-responsive gene 1 protein, CeHRG-1.
What is the protein family that this protein belongs to?
Belongs to the HRG family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein: TRM3_EHV1B
Sequence: MFGRVLGRETVQYFEALRREVQARRGAKNRAAEAQNGGEDDAKTAFLNFAIPTPQRHQTVVPGVGTLHDCCETAQIFASVARRLLFRSLSKWQSGEARERLDPASVEAYVDPKVRQALKTISFVEYSDDEARSCRNAYYSIMNTFDALRSSDAFHQVASFVARFSRLVDTSFNGADLDGDGQQASKRARVDVPTYGKQRGTLELFQKMILMHATYFIAAVILGDHADRIGAFLKMVFNTPEFSDATIRHFRQRATVFLVPRRHGKTWFLVPLIALALATFKGIKIGYTAHIRKATEPVFDEIGARLRQWFGNSPVDHVKGENISFSFPDGSKSTIVFASSHNTNGIRGQDFNLLFVDEANFIRPEAVQTIIGFLNQTNCKIIFVSSTNTGKASTSFLYNLKGAADDLLNVVTYICDEHMERVKAHTNATACSCYILNKPVFITMDGAMRNTAELFLPDSFMQEIIGGGNVSGAHRDEPVFTKTAQDRFLLYRPSTVANQDIMSSDLYVYVDPAFTTNAMASGTGVAVVGRYRSNWVVFGMEHFFLSALTGSSAELIARCVAQCLAQVFAIHKRPFDSVRVAVEGNSSQDAAVAIATNIQLELNTLRRADVVPMPGAVLFYHCTPHGSSVAYPFFLLQKQKTGAFDHFIKAFNSGSVLASQELVSNTVRLQTDPVEYLLTQMKNLTEVVTGTSETRVFTGKRNGASDDMLVALVMAVYLSSLPPTSDAFSSLPAQ
What is the function of this protein?
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging.  Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm.  Once the complex reaches the host nucleus, it interacts with the capsid portal vertex.  This portal forms a ring in which genomic DNA is translocated into the capsid.  TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
What are the official names of this protein?
Tripartite terminase subunit 3, Terminase large subunit.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae TRM3 protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2.
Protein: CBID_PSEPW
Sequence: MREETREQPAPLRSGLTTGSCATATSLAAARLLLTGVSTDAVSITLPKGKVVQMRLEFCRREDERAEAGTLKDAGDDPDVTHGALLYSQVRLQDEPGIRFVAGVGVGTVTRPGLVLAVGEPAINPVPRRMISEHLQQLADDCAYRGGFEVTVNVKGGEQLALKTMNPRLGILGGLSILGTSGIVRPFSCAAYIASIHQGIDVAHTNGYTHIAACTGNASEDTMRRVYGLPEIALIEMGDFVGAVLKHLRKVPVPRLSLCGGFGKISKLAAGHMDLHSRHSSIDLPQLAGWAADIGADADLQAAIMAANTSQQALALAHAAGIALGDAVCAHALAFARSVVPAQVQVEVFAIDRQGGIVGKAGMQ
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: GPDA_CLOPE
Sequence: MSKVAFLGAGSFGTSLGILLGNKGVTVSLWDRDENVINDINVNRKNDKYIKDLTIPTNVTAYKDLDEALNGAEYVVLAVPSHVIRTACKNLKGKINDDVIIINIAKGIEEGTNLRLSQVINQELPNNKVVVLSGPSHAEEVSKGIPTTLVASSECMECAEKVQDLFMDKNFRIYTNDDIIGVEIGGAVKNIIALAAGVCDGIGYGDNSKAALMTRGMAEIARIGIKMGGKAETFFGLTGMGDLIVTCTSMHSRNRRAGILIGQGKTAEEAIEEVGMVVEGIKACKAFYELKEKEGVTMPITDIAYKVLFEGAKAENAVSLLMERDKKKEEI
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CL16A_MOUSE
Sequence: MFGRSRSWVGGGHSKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENPDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYTKPAQDVPRSSAKPSIRCFIKPTETLERSLEMNKHKGKKRMQKRPNYKNVGEEEDEERGSAEDAQEDAEKTKEIEMVIMKLGKLSEVAAAGTSVQEQNTTDEEKSAATNSENAQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLKRIQLPVPSEAEKTTYNHLLAERLIRIMNNAAQPDGRIRLATLELSCLLLKQQVLTSSGCVIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTIKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFVFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLCSSSSSSQHLPFRFYEQCRRGSSDPTVQRSVFASVDKVPGFAVAQCINQHSSPSLSSPSPPFASGSPGGSGSTSHCDSGGSSSAPSATQSPADAPTTPEQPQPHLDQSVIGNEMDVNSKPSKNSSARSSEGETMHLSPSLLPAQQPTISLLYEDTADTLSVESLTIVPPVDPHSLRALSGISQLPTLPAADTETPAEGAVNPEPAEPTEH
What is the function of this protein?
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway.  Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.  The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy.  May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN.  Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
What are the official names of this protein?
Protein CLEC16A.
What is the protein family that this protein belongs to?
Belongs to the CLEC16A/gop-1 family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Note=Associates with the endolysosome membrane.