PharMolix/UniProtQA huggingface dataset:
Protein: RPAP1_BOVIN
Sequence: MLSRPKPGESEVDLLRFQSQFLAAGATPAVQLVKKGSRRAGDANLEQPPLQDHRDVVMLDSLPDLPPALVPAPPKRARPSPGHLLPEHEDPEERLHRHDQHITAVLTKIIERDTSSMPVNLPVSSGVAFPPVFHRSQGRQGKPVTAGKRSIFAQEIAARRASGAKVSPVREVESILDPPESAMTCEALTPREWGSQPPWNSYSFQGPHLVTGKGLKGQEAEQEAQTIHEENVARLQALAPEEILQEQQRLLAQLDPSLVAFLKSHSCTREQAEEKATREQRPGRPSAEVIGKEAIAPTSASVPRQENELEPETPALALPVTPQKEWLHMDTVELEKLHWTQDLPPLRRQQTQERMQARFSLQGELLAPDMDLPTHLGLHHHGEEAERAGYSLQELFHLTRSQVSQQRALALHVLAQVIGRAQAGEFGDRLVGSVLHLLLDAGFLFLLRFSLDDRVDGVIAAAVRALRALLVAPGDEELLDSTFSWYHGALMFALMPSQEDKEDEDEDEEPPAEKAKTKSPEEGNRPPSDLARHDIIKGLLATNLLPRLRYVLEVTCPGPSVVLDILTVLIRLARHSLESATRVLECPRLVETVVREFLPTSWSPMGSGPTSSLHRVPCAPAMKLLRVLASASRNIAARLLSGFDLRSRLSRFIAEDPQDLALPLEEAETLSTEAFRLWAVAASYGLGSDLYRELYPVLMQALQDVPKELSSPPPRPLAVQRIASLLTLLTQLTLAAGHIAPEHNSHSAEASLLAGSSSVTWTQVSGLQPLVEPCLRQTLKLLPRPEMWSALGPVPTACLLFLDAYYQAWSQQPGLCPEDWLQDMERLSEGLLLPLLKHPSLGSLWDSLGCCSPLCNPQSCAVAPETISSLASLGCAGGHPPLSLAGSASPFPFLTALLSLLNTLGRIHKGLCGQLATVLAAPGLQDYFLRCVAPVAALHLTPFSAWALRHEYHLQYLALTLAQRAATLQPPMSGTDAALCHGMALALLGRLLPGSEHLAHELMLSCVFRLEFLPERASGGPEAADFSDRLSLGSGGDLGCGRGALLAQACQDLPSIRSCYLTHCSLARASLLASQALYRGELQRVPALLLPVPKEPLLPTDWPFLPLIQLYHRASDTPSGLPPADTVGTALRALQWVLVLESWRPRALWAVSPAARLARLMCVFLVDSELFRETPIQRLVAALLARLCQPEVLSNLNLDCPLPGLTSFPDLYANFLEHFEAVSFGDHLFGALILLPLQRRFSVTLRLALFGEHVGALRALGLPLTQLPVSLECYTAPPEDNLALLQLYFRALVTGALRPRWCPVLYAVAVAHVNSFIFSQDPNNSDEIKAACRSMLQKTWLLTDEGLRQHLLHYKLPNSALPEGFELYPQLPPLRQQYLQKLRISGVLPNGVSDT
What is the function of this protein?
Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.  Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).
What are the official names of this protein?
RNA polymerase II-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the RPAP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YBED_ECOBW
Sequence: MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYTPTVKPSSKGNYHSVSITINATHIEQVETLYEELGKIDIVRMVL
What are the official names of this protein?
UPF0250 protein YbeD.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: NDHJ_CALFG
Sequence: MQGRLSAWLVKHGLVHRSLGFDYQGIETLQIKPEDWYSIAVISYVYGYNYLRFQCAYDVAPGGLLASVYYLTRIQYGVDQPEEVCIKVFAPRRNPKIPSVFWIWKSADFQERESYDMLGISYENHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RL6_LIGS1
Sequence: MSRIGYKVVNLPEGVEVKQDGNVVTVKGPKGELTREFSDKITIKVEGNEVSFERSAEDNKTKALHGTTRSNFHNMVVGVSEGFKKELELRGVGYRAQMKGKTLVLNVGYSHPVEFEEEEGITFETPSATSIIVSGINKEEVGDCAARIRATRAPEPYKGKGIRYVGEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: CGLR_DROEU
Sequence: MENFAEKKISKPLTFGEGIQYVLDRISIKPEDRQTFKEDAQQIQNEFVRAISKQDPYFASAFRGLALTGSSLDNVRINLPDEFDMLTKIKMPCKLEPVPIRSHPGYVFLRASGDNIPIHLVDRWEDEYCIDRLKVQAWFRDNITAVIPELSNIRCNDGRSYELVNKTIGDVAHTIQAKCLSDPDRSISFDFVPAFEFSASEWPRIFPQHRNEDRSWYAVPSEFKYPNVGDDPLSFLVCAPYWERMVLTKKQHLKDGYRLMKAMRDANDMPKIYSYTIKSVFLNASNVNKLINWNQSPGRILIRAIDLLAMFLRKGKLPSYLVPDRNMLDRLSVDMRQDYRRKLCHIFRRLIRCRDRDCMTSEDLQFIFGMRY
What is the function of this protein?
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:34261127).  Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG (By similarity).  Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:34261127).  Directly binds dsRNA longer than 15 bp, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:34261127).
What are the official names of this protein?
Cyclic GMP-AMP synthase-like receptor, cGLR.
What is the protein family that this protein belongs to?
Belongs to the mab-21 family.
Protein: SP3AA_BACSU
Sequence: MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRGQPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGGVKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLSSTGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSPEVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYLELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC
What are the official names of this protein?
Stage III sporulation protein AA.
Protein: RR13_PORPU
Sequence: MARIAGVDLPRNKRIEIALTYIYGIGLSRSKEILKKTNIDADIRCQNLNDQQIVSIREILESSYQIEGDLKRFESMSIKRLMEISTYRGRRHRLGLPLRGQRTRTNARTRRGGKKTVAGKKKAPRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.
What are the official names of this protein?
30S ribosomal protein S13, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL35_LACP3
Sequence: MPKFKTHRASAKRFKKTASGALKRGHAYTSHRFHGKTKKQRRQLRKSALVSHSDMKRIRQMLSQMK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RSMH_STRMU
Sequence: MTNDFHHITVLLHETIDMLDIKPDGIYVDATLGGAGHSECLLSKLGKEGHLYCFDQDQKAIDNAKIRLQQYVKTGQVSFIKDNFRHLKSRLADEGIYEIDGICYDLGVSSPQLDERERGFSYKKDAPLDMRMNQDAQLTAFDVVNTYDYRDLVRLFFKYGEDKFSKQIARKIESARKEKLIETTAELAEIIKSAKPAKELKKKGHPAKQIFQAIRIEVNDELGAAEESLTQALDLLALNGRIAVITFHSLEDRLTKQLFKEVTTLDVPKGLPFVPENLQPKFSLVNRKPILPNARELSENNRAHSAKLRVIQKIRN
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNR1_HUMAN
Sequence: MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
What is the function of this protein?
Only binds 2-arachidonoylglycerol (2-AG) with high affinity.  Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes.
What are the official names of this protein?
Cannabinoid receptor 1, CB-R, CB1, CANN6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft. Mitochondrion outer membrane. Cell projection, axon. Presynapse. Note=Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity). Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity).
Protein: CYB_METSE
Sequence: MVGYAMGHSRPTMQFRKENPVLSIVNGIIIDLPAPANLSYMWNFGSLLGVCLVVQMATGIFLAMHYCSDVSLAFASVDHIMRDVNYGFLLRYFHANGASMFFLCLYFHVGRGIYYGSYTKVEVWNVGVVLFILTMATAFLGYVLPWGQMSFWGATVITNLLSAIPYVGTDIVQWVWGGFSVSNATLNRFFSLHYLLPFVLAALGVVHLICLHVSGSNNPIGVRSDLDKVPFHTYYTSKDWYGIVAFVLFFCSLVYLAPNLLGDPENFIQANPLVTPVHIQPEWYFLFAYAILRSIPNKLGGVVAMFASLLILFLLPWVHTSRLRGLTFRPLARVAFWFMVTDFMLLTWIGCQPVEEPFIIVGQLASVFFFAYFLVLSPLLGYLENLLLFPKKG
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NU4LM_MACPG
Sequence: MTPTYMNIMLAFTISLLGMLTYRSHLMASLLCLEGMMMSLFIMTTLIALNTHSPLINIMPIILLVFAACEAAVGLALLVSISNTYGLDYIHNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SMS1_PIG
Sequence: MSASTMKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGRDLINLTQEDFTKPPLCRVSSDNGQRLLDMIETLKMEHHMEAHKNGHANGHLSIGTDVPAPDGSFSIKVKPNGMPNGYRKEMIKIPMPEPERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLGRQVKYSRLVNDT
What is the function of this protein?
Major sphingomyelin synthase at the Golgi apparatus.  Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER.  The direction of the reaction depends on the levels of CER and DAG in Golgi membranes.  Does not use free phosphorylcholine or CDP-choline as donor.  Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting.  Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1.
What are the official names of this protein?
Phosphatidylcholine:ceramide cholinephosphotransferase 1, Sphingomyelin synthase 1.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelin synthase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: SYT_STRP1
Sequence: MIKITFPDGAVREFESGVTTFDIAESISKSLAKKALAGKFNDQLIDTTRAIEEDGSIEIVTPDHKDAYEVLRHSAAHLFAQAAKRLFPNLHLGVGPAIAEGFYYDTDNAEGQISNEDLPRIEAEMQKIVTENYPCIREEVTKEEALELFKDDPYKVELINEHAGAGLTVYRQGEFVDLCRGPHVPSTGRIQVFHLLNVAGAYWRGNSDNNMMQRIYGTAWFDKKDLKAYLTRLEEAKERDHRKLGKELDLFMISQEVGQGLPFWLPDGATIRRTLERYITDKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPVMDMGDGEEFVLRPMNCPHHIQVYKNHVRSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHIFVTPEQIQEEFQRALQLIIDVYADFNLTDYRFRLSYRDPNDTHKYYDNDEMWENAQSMLKAALDEMGVDYFEAEGEAAFYGPKLDIQVKTALGNEETLSTIQLDFLLPERFDLKYIGADGEEHRPVMIHRGVISTMERFTAILIETYKGAFPTWLAPHQVTVIPISNEAHIDYAWEVAKTLRDRGVRADVDDRNEKMQYKIRASQTSKIPYQLIVGDKEMEDKSVNVRRYGSKTTHTESVEEFVENILADIARKSRPDAQA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4LM_RHIMO
Sequence: MALIYTNTLLAFTISLLGLLLYRSHLMSSLLCLEGMMLSMFVMVAVMILNTHLTTSSMMPIVLLVFAACEAALGLSLLVMVSNTYGIDHVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL23_THIDA
Sequence: MGAISQERLLKVILAPVISEKSTRVADKLNQVVFRVLPDATKQEIGAAVASLFKVEVAGVQVLNVKGKVKRSGRVMGRRDSWKKAYVTLKPGQDIDFASGQ
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PDXJ_RHOPS
Sequence: MPKTPPLRLGVNIDHIATVRNARGGRHPDPVRAALAAIEAGADGITAHLREDRRHIRDNDMERLKAEISKPLNFEMAATPDMVRIALGIKPHAVCLVPERREELTTEGGLDVVGQRESLAPSIARFNDAGIRVSLFIAADPAQIEMAARLKAPAIEIHTGAWCDAITDDEPAKAAEEWRRIVAGAALAQAAGLEVHAGHGLDYATAETIAALPQIVELNIGFYMIGEALFVGLGETVKAMRATMDRGRARVIAA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_YERPY
Sequence: MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFFDSDQEIERRTGADVGWVFDVEGEEGFRDREEKVINELTEKQGIVLATGGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQVDEPPREVLEALAKERNPLYEEIADVTIRTDDQSAKVVANQIINMLESN
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 1, SK 1.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFM_MOUSE
Sequence: MVCLALVRAAYEHIYLVRKVSHACRCHQHRAWSSKPAASQSAVQGAPGSVLEILGKSYPQDDHTNLTQKVLSKVGRNLHNQKFHPLWLIKERVKEHFYQQYMVRSRTPLFSVYDQLPPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRAHMLRAHTSAHQWDLLHAGLNAFLVVGDVYRRDQIDCQHYPVFHQLEGVRLFSKHELFAGVKDGESLQLFEEGSRSAHKQETHTMEAVKLVEFDLKQVLTRLVTHLFGDGLEVRWVDCYFPFTHPSFEMEINFRGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMVLYDIPDIRLFWSEDERFLKQFLLSDINQSVKFQPLSKYPAVFNDISFWLPSENYTENDFYDIVRTVGGDLVEKVDLIDKFEHPKTHRTSHCYRITYRHMERTLSQREVGNVHQAVQEAAVQLLGVEGRF
What is the function of this protein?
Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.  To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins (By similarity).
What are the official names of this protein?
Phenylalanine--tRNA ligase, mitochondrial, Phenylalanyl-tRNA synthetase, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Mitochondrion.
Protein: LSRA_YERPA
Sequence: MPHTVATPPPLLQVRGISKQFSGVVVLKSIDFTLQPGQVHALLGGNGAGKSTLMKIIAGILPPDTGVIEMNGQPCFNLTPAKAHQLGIYLVPQEPMLFANLSVQENILFRLPKHQADKKKMAQLLKNLGCHLDLSVSAGSLEVADQQLVEIMRGLIRDSHILILDEPTASLTPAETHRLFSQIRMLLQQGVGVVFISHKLPEIRQLADWVSVMRDGGIALSGATADFSTEDMIQAMTPEAQKGALTDSQKLWLELPGNRRAQSHAQSQQPVIHVHDLSGEGFAHISFHVQAGEILGLAGVVGAGRTELAETLYGLRPASTGNVILEEVNITAMKTANRLAAGLVYLPEDRQASGLYLDAPLSWNVCALAHDRQGLWTQPAQEAAVLERYRRALNIKFSHLEQPVRTLSGGNQQKLLIAKCLEANPLLLIIDEPTRGVDVSARSDIYQLIRSIAEQQVAIIFISSDLEEVVQMADRVLVMHQGEINGALSGAAMNVDTIMHMAFGEHRSASEPQGGTASSAENKGASC
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Autoinducer 2 import ATP-binding protein LsrA, AI-2 import ATP-binding protein LsrA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL3_FRACC
Sequence: MLIRNYRGLLGTKLGMTQVWDANNRVVPVTVIKAGPNVVTQVKTPDSDGYSAVQLGYGEVDPRKINKPARGHFATSGVTPRRHLVELRTADAGNYRPGQELTGEVFSAGTVVDVTGTSKGKGFAGVMKRHGFKGLGAGHGVERKHRSPGSVGGCATPGRVFKGLRMAGRMGHVRTTTSGLTIHAVDTERGYLLVRGAVPGPDGGLVLVRSAAKRPAPEAIAPAAELAGTGEEVSA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ERYG_SACEN
Sequence: MSVKQKSALQDLVDFAKWHVWTRVRPSSRARLAYELFADDHEATTEGAYINLGYWKPGCAGLEEANQELANQLAEAAGISEGDEVLDVGFGLGAQDFFWLETRKPARIVGVDLTPSHVRIASERAERENVQDRLQFKEGSATDLPFGAETFDRVTSLESALHYEPRTDFFKGAFEVLKPGGVLAIGDIIPLDLREPGSDGPPKLAPQRSGSLSGGIPVENWVPRETYAKQLREAGFVDVEVKSVRDNVMEPWLDYWLRKLQDESFKKSVSRLFYSQVKRSLTSDSGMKGELPALDFVIASARKPGA
What is the function of this protein?
S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes the last step in the erythromycin biosynthesis pathway.  Methylates the position 3 of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A.  Can also methylate the precursor erythromycin D, forming erythromycin B.
What are the official names of this protein?
Erythromycin 3''-O-methyltransferase, Erythromycin biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: KAD_PSEP1
Sequence: MRVILLGAPGAGKGTQAKFITEKFGIPQISTGDMLRAAVKAGTPLGLELKKVMDAGQLVSDELIISLVKERIAQPDCANGCLFDGFPRTIPQAEAMVAAGVDIDAVVEIAVDDEEIVGRMAGRRVHLASGRTYHIQYNPPKVEGKDDETGEDLIQRDDDKEETVRHRLSVYHSQTKPLVDFYQKLSAANGGKPKYSHIEGVGSVEAITAKVLAALS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_SALAR
Sequence: MAKGIREKIKLVSSAGTGHFYTTTKNKRTKPEKLELKKFDPVVRQHVIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: OAT_OCEIH
Sequence: MTITSTNIIEETNYYGAHNYHPLPIVVSEANGVWVKDPEGNSYMDMLSAYSAVNQGHRHPKIIEALKNQADKVTLTSRAFHNELLGPWTKRMAKLTKKDKVLPMNTGVEAVETAIKAARRWAYQVKGVTENQAEIIAADGNFHGRTLNAISLSNDPDATKNYGPFVPGINKVSYGDINAIEKAITENTAAIILEPIQGEAGIIIPPEGYLKKVRELCSEKNILFIADEVQTGFARTGKMFACEWENVEPDIYVMGKALGGGVFPVSAIAANNEIMDVFTPGSHGSTFGGNPLACAVSMAAIDVIEEENLVNKSLESGKYFADKLRAVNFEGIKEVRARGLFIGMEFHQPVREICEKLKDKGILCKETHVNTIRFAPPLVITKDEMDWAIQRIEEVLTN
What is the function of this protein?
Catalyzes the interconversion of ornithine to glutamate semialdehyde.
What are the official names of this protein?
Ornithine aminotransferase, OAT, Ornithine--oxo-acid aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PACN1_PONAB
Sequence: MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKSEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWSDDESGNPFGGSEANGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI
What is the function of this protein?
Binds to membranes via its F-BAR domain and mediates membrane tubulation.  Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization.  Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes.  Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex.  Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length.  Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission.  Required for normal excitatory and inhibitory synaptic transmission (By similarity).
What are the official names of this protein?
Protein kinase C and casein kinase substrate in neurons protein 1.
What is the protein family that this protein belongs to?
Belongs to the PACSIN family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection. Synapse, synaptosome. Cell projection, ruffle membrane. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites. Colocalizes with MAPT in axons (By similarity).