PharMolix/UniProtQA huggingface dataset:
Protein: TP8L3_XENLA
Sequence: MDTDSGDLSEGELSPGPEQFSSKSFAVQAQKKILSKMATKTMANMLIDDTSSEIFDELFKVTKEYVKNKKEAHKVLKDLVKVAVKVGILYRNKQFSLEELEIVENFRKKLNQTCMTAVSFFEVEYTFDKNVLSGLLHECKTLLHELVQRHLTPKSHSRIDRVFNHFADVEFLTALYSLEGNYRPYLKRICEGVNKLLDERVL
What is the function of this protein?
May act as a lipid transfer protein.
What are the official names of this protein?
Tumor necrosis factor alpha-induced protein 8-like protein 3, TNF alpha-induced protein 8-like protein 3, TNFAIP8-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the TNFAIP8 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.
Protein: THIE_STAA2
Sequence: MFNQSYLNVYFICGTSDVPSHRTIHEVLEAALKAGITLFQFREKGESALKGNDKLVLAKELQHLCHQYDVPFIVNDDVSLAKEINADGIHVGQDDAKVKEIAQYFTDKIIGLSISDLDEYAKSDLTHVDYIGVGPIYPTPSKHDAHIPVGPEMIATFKEMNPQLPIVAIGGINTNNVAPIVEAGANGISVISAISKSENIEKTVNRFKDFFNN
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RS16_MYCSK
Sequence: MAVKIKLTRLGKIRNPQYRIVVADARTRRDGRSIEVIGRYHPKEEPSLIELNSERAQYWLGVGAQPTEPVLQLLKITGDWQKFKGLPGAEGTLKVKEPKPSKLDLFNAALAEAEGGPSNEATQPKKKKAPAKKAASDIEATADPAGNADKSEPAAEGEDATVAGATEG
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: NADA_PSESM
Sequence: MTQISERFLVQAHLDAKQPKALSPEEQAHYRAAIAAELKKQDAVMVAHYYCDPVIQALAEETGGCVADSLEMARFSNNHPASTVLVAGVRFMGETAKILNPEKRVFMPTLEATCSLDVGCPVDEFSAFCDQHPERTVVVYANTSAAVKARADWVVTSGCALEIVESLMDNGEKIIWAPDKHLGRYIQRETGADMLLWDGACIVHEEFKSKQLEDMKALYPEAAILVHPESPEAVIELADVVGSTSQMIAAAQRLPNKMFIVATDRGIFYKMQQLCPDKIFIEAPTAGNGAACRSCAHCPWMAMNTLERTLQCLREGGNEIFVEPALIPNAVRPLQRMLDFTQAARLRQAGNA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRR22_HUMAN
Sequence: MQHPKPFCAPAAPQEGFSPQSLEGAEVLGNQPAPTCAEPPPAMGSLNLYHPPDPEKEVFPAPPAGFQMAPCGCFFDPRIYRIEWTTPDLGQSALYKLAASSGGPAGVPSAPGSYLLEPQPYLKAPGLPPYPHYQQAPGGPQFLLPYFPPEGPGPEALGFVGDAGPAAFVELPLPPLEEGPAPLPPPPPKENKPPPVLITLPAEPTLPPDAYSHLQGHLGHFPGPEPLAFPVKELQGSGARPGVPLYPPGLSELKVAEVKEGALLGAGKAKAPKTARALALPDKVLLEDAMKLFDCLPGASEPEGTLCEVPGPALPDSSGGNSADDIRSLCLPEELLSFDYSVPEILDTVSNVDYFFNFKALDEEQPPHPGPPATNTPAPILSGKRKASTAKKGKPGRKARQPAGPASATPPGPREDLGATPH
What are the official names of this protein?
Proline-rich protein 22.
Protein: RM45_CAEBR
Sequence: MLGRALIRTFLSPTVPVAACTTQIAGVHHHKEAGDMKRFTGVTRSNKAKANRNTHVNEKLFRKMRGRKTLLVELPEDSARERESEMPPGEMRTELLKRGLNPYKEAQPRVWNEAQVTFQSIYGIADPYVPPETPASFTDVNNKFDEVKQRLQHKFYNWRMGTNRIRKKQGFEKFDVKTFCAKAEDIYERAHKAMEARDKKEMYRCITEYAFAKMWPDVENGSVRFELVSIVEPSRVVAVRCFDNPPKSGNDIAQITVRMHTRQKLALYDRFGGLILGSEDEEKDVVEYVVFENHIAVVDGEWRLHGKIYPKWIEPKQGTHITHQLTQKEAGVQVAKANALPLRTTEKLEEAKKEKEAANSS
What are the official names of this protein?
Probable 39S ribosomal protein L45, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL45 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RSMJ_YERPY
Sequence: MSHVSICLLSEAGADPGALSILADRWGLVSDDQAVMALVLTAERLELRKRDEPKLGGIYVDFVSGTQAHRRKFGGGRGEAVAKAVGIKKGYLPRVVDATAGLGRDAFVLAALGCQVQMLERNPVVAALLDDGLRRGYLDAEIGPWLRERLTLLHASSLTALVAIEPCPEVVYLDPMYPHRQKSALVKKEMRVFQSLVGADNDADGLLAPARALATKRVVVKRPDYAEPLAGVAAQAAVVTKSHRFDIYPSSVTPPR
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_MYCGE
Sequence: MKRCYITTPIYYASGKPHIGHAFTTILADVIKRFKIQNGYEAFLLVGSDEHGNKIESKAKSLNLDPKTFVDINAQAFKLMWKTLNISFDHFIRTTDEIHKQQVQKTFQDLYDKKLIYQSEWKGAYCVECEQNYFTFNKQTMLCEIGHNLSLVQEPCWFISFSSTKNWIETTIGKNQLNIIPKSRASELKNNFINNGLNDLALTRKNVTWGIKVPFDPNQTIYVWFDALFSYITNLGFRNGDPNFIKWWNNDNKEREVIHLISREITRFHCIYWPIFLHLLDIKLPTQFLSHGWIVDGEGRKMSKSLNNVISPEQLIDQFGVDGTRYCLLKEMRLDKDNRCSVSILKEIYNADLANSFGNHVSRTFGMIKKYLNGKLEYQIITDNALQKIMILIDESIVQFDHYFNSYEFYRAINLLLKIVFELSKLIDDFKPWELFKNQEFSLLKQLLFTCVRCVQVCYVLLTPILVNTASKVFHLFNFADDACRKDQLRDATLLKKIIISNSMEVLFKRVD
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_THENN
Sequence: MPGQRIRIKLKAYDHELLDESAKKIVEVAKSTNSKVSGPIPLPTERTLYCVLRSPMKHKDSREHFEKRVHKRLIDIIDPSPKTIDALMRINLPAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: SIXP_MESMA
Sequence: MKFFLIFLVIFPIMGVLGKKNGYAVDSSGKVAECLFNNYCNNECTKVYYADKGYCCLLKCYCFGLADDKPVLDIWDSTKNYCDVQIIDLS
What is the function of this protein?
Excitatory insect beta-toxins induce a spastic paralysis (PubMed:10400300).  They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  In vivo, induces paralysis on insects (PubMed:11042276).  When tested on mice, it does not show toxicity but has an analgesic effect (PubMed:10400300).
What are the official names of this protein?
Beta-insect excitatory toxin BmK IT-AP, Bm33-I, Insect toxin-analgesic peptide, BmKITAP.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ACTN3_HUMAN
Sequence: MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKQNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL
What is the function of this protein?
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures.  This is a bundling protein.
What are the official names of this protein?
Alpha-actinin-3, Alpha-actinin skeletal muscle isoform 3, F-actin cross-linking protein.
What is the protein family that this protein belongs to?
Belongs to the alpha-actinin family.
Protein: FLAB_LEPIN
Sequence: MIINHNLSAVNAHRSLKFNELAVDKTMKALSSGMRINSAADDASGLAVSEKLRTQINGLRQAERNTEDGMSFIQTAEGFLEQTSNIIQRIRVLAIQTSNGIYSNEDRQLVQVEVSALVDEVDRIASQAEFNKFKLFEGQFARGSRVASMWFHMGPNQNQRERFYIGTMTSKALKLVKADGRPIAISSPGEANDVIGLADAALTKIMKQRADMGAYYNRLEYTAKGLMGAYENMQASESRIRDADMAEEVVSLTTKQILVQSGTAMLAQANMKPNSVLKLLQQI
What is the function of this protein?
Component of the core of the flagella.
What are the official names of this protein?
Flagellar filament 35 kDa core protein, 35 kDa antigen, Flagellin class B.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Periplasmic flagellum. Periplasm.
Protein: WRK31_ARATH
Sequence: MFRFPVSLGGSRDEDRHDQITPLDDHRVVVDEVDFFSEKRDRVSRENINDDDDEGNKVLIKMEGSRVEENDRSRDVNIGLNLLTANTGSDESTVDDGLSMDMEDKRAKIENAQLQEELKKMKIENQRLRDMLSQATTNFNALQMQLVAVMRQQEQRNSSQDHLLAQESKAEGRKRQELQIMVPRQFMDLGPSSGAAEHGAEVSSEERTTVRSGSPPSLLESSNPRENGKRLLGREESSEESESNAWGNPNKVPKHNPSSSNSNGNRNGNVIDQSAAEATMRKARVSVRARSEAAMISDGCQWRKYGQKMAKGNPCPRAYYRCTMAGGCPVRKQVQRCAEDRSILITTYEGNHNHPLPPAATAMASTTTAAASMLLSGSMSSQDGLMNPTNLLARAILPCSSSMATISASAPFPTITLDLTNSPNGNNPNMTTNNPLMQFAQRPGFNPAVLPQVVGQAMYNNQQQSKFSGLQLPAQPLQIAATSSVAESVSAASAAIASDPNFAAALAAAITSIMNGSSHQNNNTNNNNVATSNNDSRQ
What is the function of this protein?
Transcription factor.  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
What are the official names of this protein?
Probable WRKY transcription factor 31, WRKY DNA-binding protein 31.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACT_GIAIN
Sequence: MTDDNPAIVIDNGSGMCKAGFAGDDAPRAVFPTVVGRPKRETVLVGSTHKEEYIGDEALAKRGVLKLSYPIEHGQIKDWDMMEKVWHHCYFNELRAQPSDHAVLLTEAPKNPKANREKICQIMFETFAVPAFYVQVQAVLALYSSGRTTGIVIDTGDGVTHTVPVYEGYSLPHAVLRSEIAGKELTDFCQINLQENGASFTTSAEFEIVRDIKEKLCFVALDYESVLAASMESANYTKTYELPDGVVITVNQARFKTPELLFRPELNNSDMDGIHQLCYKTIQKCDIDIRSELYSNVVLSGGSSMFAGLPERLEKELLDLIPAGKRVRISSPEDRKYSAWVGGSVLGSLATFESMWVSSQEYQENGASIANRKCM
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: H2A2B_MOUSE
Sequence: MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTESHKPGKNK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A type 2-B, H2A-clustered histone 21, H2a-613A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: YKT6_KLULA
Sequence: MKIYYIGVLRNSDDKTLELSSVKDLSQFGFFERNSVAQFMSFFSETVAGRTSAGQRQSVEEGNYVGHVYARPEGICGVLITDKEYPVRPAYTLLNKVLDEYLVAHPPIQWKDVTESDDSLKLKELDIYIAKYQDPSQADAIMRVQQELDETKITLHKTIENVLQRGEKLDNLVDKSESLSAASRMFYKQAKKTNSCCIVM
What are the official names of this protein?
Synaptobrevin homolog YKT6.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: RL14E_METM5
Sequence: MAAIEVGRVCIKTLGREAGNTCVIVEVLDKNFVVIDGSVKRRRCNLKHFEPTDKKVDLEKAASTEEVKLALDAAGLL
What are the official names of this protein?
50S ribosomal protein L14e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.
Protein: ISPH_FRATT
Sequence: MKILLANPRGFCAGVSRAVETVEKVLEVEKSPVYVRHEVVHNKVVVDSLKKKGVVFVKEVDEVPDDAVCIFSAHGVSLKVEEAAAKKNLVLYDATCPLVTKVHRGVRLASNNDAECILIGHKGHPEVQGTMGQYRSKKGAIYLIESEEDLNKLTIKDPDNLYYATQTTLSVDETQGIIQALKDKYPNIKGPKKEDICYATQNRQTAIKAMLKHIDVLVVVGSQNSSNSNRLKELATLEGIDAYLVDNPKDVDKLWFDNKKVCGVSAGASAPEYLVQQIISQISKVCSTEVEEFEGIKEEVYFPLPRLLKQKIGTGKVE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: PCKA_RUBXD
Sequence: MDLAVRKMTLEGLGVSQLGAVHENLPPARLVEASVRRREGMLAENGALVCLTGKRTGRSPKDRFIVENGLTRGPVDWGPVNKPFPGERFERLLAKASAYLENLEEVYVVDAYAGADPRYRLNVQVVCEYAWQALFTRQLFRRPSREELDAFEPDWTVISVPGLLTDPEEDGTESETFVGIDFGRRVVLICGTRYAGEIKKSIFSVLNFVLPTEHGVFPMHCSANVGPGGDVALFFGLSGTGKTTLSSDPERYLIGDDEHGWSDEGIFNFEGGCYAKCIDLSREKEPQIYDAIRFGAVLENVVVDRITRRVDYSDASLTENTRAAYPLEYIEGAVDSGRAGHPAAVLFLTADAFGVLPPISVLSPEQAAYYFLSGYTAKLAGTEADMEADVEATFSACFGAPFLPLPATTYAAMLSEKLREHGSRCYLINTGWSGGPYGVGERVDIAATRQMVRAVIAGNIDESKTYTDPFFGLQVPLEVPGVPSGILNPRETWADRAAYDDQAAKLADLFRENFKKFEDGVPEGVRKAGPNV
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_SALAI
Sequence: MSHIGVAFDKARAEGRAVLVGCMPAGFPTVEGSIAAMTAMVEAGVDVIEVEIPYSDPVMDGPVIQRASDIALAGGVRVADTLRIIEAVAATGVPVVTMTYWNPVEQYGVDAFARDLAAAGGTGLITPDLIPDEAQEWLAASDAHGLDRTFLVAPSSTDTRLEMTVEHCRGFVYATALMGVTGARTQASAAAPVLVSRVRGVTDLPVGVGLGTGTGAQASTVAGFADGVIVGSALIRCLLDAPSLPAGLTALRALSAELAAGVRTPAH
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: AGP18_ARATH
Sequence: MDRNFLLTVTLICIVVAGVGGQSPISSPTKSPTTPSAPTTSPTKSPAVTSPTTAPAKTPTASASSPVESPKSPAPVSESSPPPTPVPESSPPVPAPMVSSPVSSPPVPAPVADSPPAPVAAPVADVPAPAPSKHKKTTKKSKKHQAAPAPAPELLGPPAPPTESPGPNSDAFSPGPSADDQSGAASTRVLRNVAVGAVATAWAVLVMAF
What is the function of this protein?
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
What are the official names of this protein?
Lysine-rich arabinogalactan protein 18, Lys-rich AGP 18.
What is the protein family that this protein belongs to?
Belongs to the lysine-rich AGP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: TF3C1_MOUSE
Sequence: MDALESLLDEVALEGLDGLCLPALWSRLESRSPAFPLPLEPYTQEFLWRALATHPGISFYEEPRERPDLQLQDRYEEIDLETGILESRRDPVTLEDVYPIHMILENKDGIQGSCRYFKERKDITSSIRSKCLQPRCTMVEAFSRWGKKLIIVASQDMRYRALIGLEGDPDLKLPDFSYCILERLGRSRWQGELQRDLHTTAFKVDAGKLHYHRKILNKNGLITMQSHVIRLPTGAQQHSILLLLNRFHVDRRSKYDILMEKLSMMLSTRSNQIETLGKLREELGLCERTFKRLYQYMLNAGLAKVVSLPLQEIHPECGPCKTKKGTDVMVRCLKLLKEFKRKMEDDHDDDDDEEVISKGVPPVDIVFERDMLTQTYELIERRGTKGISQAEIRVAMNVGKLEARMLCRLLQRFKVVKGFMEDEGRQRTTKYISCVFAEESDLSRQYAREKARGELLTTVSLASVQDESLMPEGEEAFLSDSESEEESSCSGGKRRGRGSRGHARASGDAGSGSRPHHSTPAKGGWKVLNLHPLKKPKAAAEERSRRSSACRDGLDTSSSSELNAPFDPHSMDSHSGDIAVIEEVRLDNPKEGGGSQKGGRHGSSQDKPHKTYRLLKRRNLIIEAVTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIIRLVRNLSEEGLLRLYRTTVIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSSTANRVKVPPAPAPQEEAEEENQEPEVPSRSANSDPNTSSKPESTRVKKTDEKMGITPLKNYKPVIVPGLGRSIGFLPKMPRLKAMHLFLWYLVYGHPAGHTGEQPALHSERKTGKQESSRPGAQPSSGDDWDTSEAKNNTESSSWESEMELSTEIVYVDEISWMRYVPPIPIHRDFGFGWALVSDILLCLPLSIFVQLVQVSYKVDNLEDFLNDPLKKHTLIRFLPRHIRQQLLYKRRYIFSVVENLQRLCYMGLLQFGPTEKFQDKDQVFVFLKKNAVIVDTTICDPHYNLAHSSRPFERRLYVLDSMQDVECYWFDLQCICLNTPLGVVRCPCAQKICPDPGSDPEGSLRKEQESAMDKHNLERKCAMLEYTTGSREVVDEGLVPGDGLGAAGLDSSFYAHLKRNWVWTSYIINKARKNNTSENGLTGRLQTFLSKRPMPLGSGGSGRLPLWSEGRADAELCADKEEQFELDREPTPGRNRKVRGGKSQKRKRLKKEPIRKTKRRRRGEHPEAKSKKLRYQDEADQNALRMMTRLRVSWSMQEDGLLMLCRIASNVLNTKVKGPFVTWQVVRDILHATFEESLDKTSHSVGRRARYIVKNPQAFMNYKVCLAEVYQDKALVGDFMSRKGNYEDPKVCAKEFKEFVEKLKEKFSSGLRNPNLEIPNTLQELFAKYRVLAIGDEKDRVRKEDELNSVEDIHFLVLQNLIQSTLSLSNSQSNSCQSFQIFRLYREFREPVLVRAFMECQKRSLVNRRRVSHSQGPKKNRAVPFVPMSYQLSQSYYKLFTWRFPTTICTESFQFYDRLRTNGMLDQPDHFSFKDLDSSDPSNDLVAFSLDSPGGHCVTALALFSLGLLSVDVRIPEQIVVVDSSMVESEVMKSLGKDGGLDDDEEEEDLDEGSGTKRQGVEVKAHQASHTKYLLMRGYYTVPGMVSTRNLNPNDSIVVNSCQVKFRLRNTPASTQLGPTGFTATPLEELQAGLSCLPASFTSLVDPQLRTHCPEEFAHQMAQSGYSPEDVAASLEILQAVAAADCFGIDKEKLSRQFSALEKIADRRTRTFLDYIQDLLEQEQVMEVGGNTVRLVTMASAQPWLLHSMRLRDMEVDTKASGDDSQSRLPEGPSIEDHTSEGAAVPPVSSHSTKKRPHCPETDAEEATRLPAKKPTLQDVRVAASPRPGAEEQAEAQAPAQLAAPEDADAGGPRQENQENVGVSGLEQLGCEFQLPEGSEDPRGLTESNMAQAAWESGCERVCFVGRPWRGVDGHLNMPVCKGMLEAVLYHIMSRPGVPESCLLQYYQGVLQPVAVLELLRGLESLGCIQKRTLRKPASVSLFSRPVVEGLGQASEAEALSCHESTVTFYEPTLDCTIRLGRVFPHDINWNKWIHL
What is the function of this protein?
Required for RNA polymerase III-mediated transcription.  Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs.  Binds to the box B promoter element (By similarity).
What are the official names of this protein?
General transcription factor 3C polypeptide 1, TF3C-alpha, TFIIIC box B-binding subunit, Transcription factor IIIC 220 kDa subunit, TFIIIC 220 kDa subunit, TFIIIC220, Transcription factor IIIC subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the TFIIIC subunit 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NEP_I80AC
Sequence: MDSNTVSSFQDILVRMSKMQLESSSGDLNGMITQFESLKLYRDLLGEAVMRMGDLHLLQSRNGKWREQLSQKFEEIRWLIEEVRHKLKTTESSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: END4_STAAB
Sequence: MLLGSHVSMSGKKMLEGSAIEAHEYGETTFMIYTGAPQNTRRKSIEDLNITKGHEVMEKYGLSNIVVHAPYIINIANTTKPETFNLGVDFLQQEIERTQAIGAKDIVLHPGAHVGAGVDAGINKIIEGLNEVLTNDNNVRIALETMAGKGTEIGRSFEELARIIDGVHNNERLSVCFDTCHTHDAGYNVKEDFDGVLNEFDKIIGVDRIKVVHVNDSKNDRGAQKDRHENIGFGYIGFDALNYIVHHDSFKDIPKILETPYVGEDKKNKKPPYKLEIEMLKQQQFDPELKNKVMQQ
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: RNAS1_AXIPR
Sequence: KESAAAKFERQHMDPSTSSASSSDYCNQMMQSRKMTQDRCKPVNTFVHESLADVQAVCFQKNVACKNGQSNCYQSNSAMHITDCRESGNSNYPNCVYKATQAEKHIIVACEGNPYVPVHFDGSV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1634_LACPL
Sequence: MEIEKNYRINSLFEFYEPLLTNKQKAYIQLYYADDYSLGEIAAEFSVSRQAVYDNIKRTEKILEGYEAKLHLYHDFVERNHEVDAISDYIKQNYHGDTQLIKMIQQLVNLEADSE
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein lp_1634.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: VP2_ROTAD
Sequence: MAYRKRGAKRENLPQQNERLQEKEIEKDVDVTMENKNNNRKQQLSDKVLSQKEEIITDAQDDIKIAGEIKKSSKEESKQLLEILKTKEDHQKEIQYEILQKTIPTFESKESILKKLEDIRPEQAKKQMKLFRIFEPKQLPIYRANGEKELRNRWYWKLKKDTLPDGDYDVREYFLNLYDQILIEMPDYLLLKDMAVENKNSRDAGKVVDSETANICDAIFQDEETEGVVRRFIADMRQQVQADRNIVNYPSILHPIDHAFNEYFLNHQLVEPLNNEIIFNYIPERIRNDVNYILNMDMNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKEKELVSTEAQIQKMSQDLQLEALTIQSETQFLAGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVIPNDMFLRESLVACELAIINTIVYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFTNNNRFRQVVIDGVLNQTLNDNIRNGQVINQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLVSYNYETLMACVTMNMQHVQTLTTEKLQLTSVTSLCMLIGNTTVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDVPRVPDDQMYRLRDRLRLLPVERRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIARNLDGYQQINLEELMRTGDYGQITNMLLNNQPVALVGALPFVTDSSVISLIAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWIPTSTTKVYKQVPQPFDFRASMHMLTSNLTFTVYSDLLSFVSADTVEPINAVAFDNMRIMNEL
What is the function of this protein?
Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices.  This capsid constitutes the innermost concentric layer of the viral mature particle.  It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini.  VP2 is required for the replicase activity of VP1 polymerase.  Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles.  May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication.
What are the official names of this protein?
Inner capsid protein VP2.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP2 family.
What are the subcellular locations of this protein?
Virion. Note=Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.