PharMolix/UniProtQA huggingface dataset:
Protein: FUS_HUMAN
Sequence: MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY
What is the function of this protein?
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383).  Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092).  Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307).  Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410).  In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).
What are the official names of this protein?
RNA-binding protein FUS, 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS, POMp75, Translocated in liposarcoma protein.
What is the protein family that this protein belongs to?
Belongs to the RRM TET family.
What are the subcellular locations of this protein?
Nucleus. Note=Displays a punctate pattern inside the nucleus and is excluded from nucleoli.
Protein: GPPA_YERP3
Sequence: MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMERGWQCLKLFSERLQDIPLDQIRVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARLIYHGVAHTTGGPEQRLVVDIGGGSTELVTGNGAQANILVSLSMGCVTWLERYFGDRHLAKENFERAELAAHEMIKPVAQRFREHGWQVCVGASGTVQALQEIMVAQGMDELITLAKLQQLKQRAIQCGKLEELEIPGLTLERALVFPSGLSILIAIFQELSIESMTLAGGALREGLVYGMLHLPVEQDIRRRTLRNLQRRYLLDTEQAKRVSCLADNFFLQVEKEWHLDGRCREFLQNACLIHEIGLSVDFKHAPQHAAYLIRNLDLPGFTPAQKLLLSALLQNQSDTIDLSLLNQQNALPADMAQHLCRLLRLAIIFSSRRRDDTLPAVRLRADNNALYVLVPQGWLEQHPYRAEALEQESHWQSYVQWPLLLEELS
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: SYP_STAEQ
Sequence: MKQSKVFIPTMREVPAEAEALSHRLLLKAGLIKQSTSGIYSYLPLATRVLNNISKIIREEMESIDAVEILMPALQQAELWEESGRWSAYGPELMRLKDRNGREFALGPTHEEVVTSLVRDELKSYKQLPLTLFQIQSKYRDEKRPRFGLLRGREFLMKDAYSFHSDEASLDATYQDMYQAYSRIFKRVGINARPVVADSGAIGGSHTHEFMALSEIGEDTIVYSNESDYAANIEKAEVVYHPSHKHSALAELTKVETPNVKTAQEVAEYLKRPLDEIVKTMIFKIDGEFIMFLVRGHHELNEVKLKSYFGTEHVEMATPDEIVNLVDANPGSLGPIFDKDIKIYADNYLQDLNNFVVGANEDHYHYINVNIGRDFDVTEYGDFRFITQGEMLSDGSGVAQFAEGIEVGQVFKLGTKYSESMNATFLDNQGKAQPLIMGCYGIGVSRTLSAIVEQNNDENGIIWPKSVTPFDIHLITINPKKDDQRTLGDQLYQKLMDSYDVLYDDRKERAGVKFNDSDLIGLPVRVVVGKRAEEGIVEVKQRINGLSEEVQIDELEYYLQELFKNIK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_UREPA
Sequence: MKDYKSTLNMPTTGFEMRANLNVKEPKIQQFWVEHQIYEKLLTKNKDKKPFILHDGPPYANGNIHIGHALNKILKDFVVSYHNMNNYYSPYIPGWDTHGLPIEVALSKKIKLSNLSVNERREQCKKYALEQVNNQIQQFLRLGMISDFKQRYLTLDHNYEIDQLKLFTYMLKKGFIYQDFKPVFWSWSSQTALAESEIEYADRQSSAIYVKMKVVDHNDLFTDKPTSLVIWTTTPWTLPANLAIAIHPELVYSLIEYKNENYIIAKPLVETFVKKVGFEDYKWIKDFKANTLEKIKYISPISKKHAFVIMDEYVSANDGTGLVHNAPAFGLEDYYACKKYGIETVVMIDQFGKYNALVNDLELENMFYEDANQVILNRLMNEHLLIHHEVITHSVAHDWRTKKPVMYRATKQWFVSIEKILPNILQTLNNDVKSTSFRGIERMHEMIVNRKEWCISRQRVWGVPIPMIFDENHNAIMDHELVENIINVLNEKGVNAWFDLDVNAFLTPKYLSMKNKTFYKEKDIMDVWFDSGSSYNILGHYNLNYPADVYLEGYDQYRGWFNSSLITGTILNNRAPYKYLVAHGMVLDGEGYKMSKSKGNVVDPLDVCKIYGADVLRLWIANSDYQNDTRISEEILKQNAEIYRRIRNTLFKYSLSILNDFEPSVDFSFNVRQEEQFVLNEFNELHIKVIKAYENFDYQTVVKLFNKFILDLSSWYFENIKDDMYCLAINDPIRKQIQSAVYWILKNSLIDLTPIIPHTTEEAYSFLKDANKKESIRLEDFYDQSQFQFKKGIAHVKAFFSIKDQIFNELENARKNNILKKNNEAFVTIAKNLILDDYLINNPKLLAKWFGVAKIEFANNTNVANANFKKCLRCWNHFPDEEMYNDELSMNCYKVINKIK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPC_BACSU
Sequence: MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEGIAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANTPTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRFQPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAIDLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHSRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDEESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNHKDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLSIELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVEDGEFVVKTTAKTN
What is the function of this protein?
Competence gene repressor; required for cell growth at high temperature.  Negative regulator of comK expression.  May interact with MecA to negatively regulate comK.
What are the official names of this protein?
Negative regulator of genetic competence ClpC/MecB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpC subfamily.
Protein: MIAA1_GEODF
Sequence: MLFNLLVILGPTASGKTRLGVELARRFFGEVLSADSRQVYRGMDIGTGKDLSEYGEVPYHLIDIVDPGYEFNVFEFQRRFEQAYNHITERGKLPVMVGGTGMYLESVLKGYRLVEVPENAQLRRQLAGFSHEALMERLGNANPRLHNSTDLLDHHRLVRAIEIAEYEAPPQAPFLPGLSPLIFGIQWDRPILRQRITERLKLRLDQGMIQEVERLHDTGIPFETLEFYGLEYRFIARHLKGELSRNDMFQKLNSAIHDFAKRQCTWFSRMERHGTVIHWLDGAADPLAEALGILSHQKTQSTPFCRP
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase 1, Dimethylallyl diphosphate:tRNA dimethylallyltransferase 1, DMAPP:tRNA dimethylallyltransferase 1, DMATase 1, Isopentenyl-diphosphate:tRNA isopentenyltransferase 1, IPP transferase 1, IPPT 1, IPTase 1.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RL19_LYSSC
Sequence: MSNIITEITKSQLRTDLPAFRPGDTVKVHVKVVEGTRERIQLFEGVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIANLEVVRRGKVRRAKLYYLRNLRGKAARIKEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: YFBU_ECO55
Sequence: MEMTNAQRLILSNQYKMMTMLDPANAERYRRLQTIIERGYGLQMRELDREFGELKEETCRTIIDIMEMYHALHVSWSNLQDQQSIDERRVTFLGFDAATEARYLGYVRFMVNVEGRYTHFDAGTHGFNAQTPMWEKYQRMLNVWHACPRQYHLSANEINQIINA
What are the official names of this protein?
UPF0304 protein YfbU.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: BP06_BPT4
Sequence: MANTPVNYQLTRTANAIPEIFVGGTFAEIKQNLIEWLNGQNEFLDYDFEGSRLNVLCDLLAYNTLYIQQFGNAAVYESFMRTANLRSSVVQAAQDNGYLPTSKSAAQTEIMLTCTDALNRNYITIPRGTRFLAYAKDTSVNPYNFVSREDVIAIRDKNNQYFPRLKLAQGRIVRTEIIYDKLTPIIIYDKNIDRNQVKLYVDGAEWINWTRKSMVHAGSTSTIYYMRETIDGNTEFYFGEGEISVNASEGALTANYIGGLKPTQNSTIVIEYISTNGADANGAVGFSYADTLTNITVININENPNDDPDFVGADGGGDPEDIERIRELGTIKRETQQRCVTATDYDTFVSERFGSIIQAVQTFTDSTKPGYAFIAAKPKSGLYLTTVQREDIKNYLKDYNLAPITPSIISPNYLFIKTNLKVTYALNKLQESEQWLEGQIIDKIDRYYTEDVEIFNSSFAKSKMLTYVDDADHSVIGSSATIQMVREVQNFYKTPEAGIKYNNQIKDRSMESNTFSFNSGRKVVNPDTGLEEDVLYDVRIVSTDRDSKGIGKVIIGPFASGDVTENENIQPYTGNDFNKLANSDGRDKYYVIGEINYPADVIYWNIAKINLTSEKFEVQTIELYSDPTDDVIFTRDGSLIVFENDLRPQYLTIDLEPISQ
What is the function of this protein?
Baseplate protein that is located next to the tail tube (inner baseplate) (PubMed:27193680).  Involved in the tail assembly (PubMed:21129200).  The gp25-(gp6)2-gp7 module is involved in sheath contraction (PubMed:27193680).
What are the official names of this protein?
Baseplate wedge protein gp6, Gene product 6, gp6.
What is the protein family that this protein belongs to?
Belongs to the T4likevirus baseplate wedge protein gp6 family.
What are the subcellular locations of this protein?
Virion. Note=12 copies of gp6 form a continuous ring that makes up most of the inner baseplate.
Protein: SYP_SULTO
Sequence: MKVSKEKWEKNFSEWLDWVLREAEIYDYGRYPVKGMGVWMPYGFKIRQNVLQLIRKLLDETGHEEVLFPLLIPEDLLKKESEHIRGFEEEVYWVTKGGSQDLDVKLALRPTSETSITFMESFWVKSYKQLPKKYYQIVSVFRYETKATRPMMRLREITTFKEAHTLHETYEDAARQVDEAINIYKAFFDELGIPYMISKRPEWDKFAGAEYTIAFDTILPDSRVLQIGTVHHLGQHFTKAFDFKIQRKDGSLDYPHQTSYGISDRVIAVLIAINGDDHGPVLNPVIAPIKVVIVPIPAKDEETTAKIINYAKEVGENLKNRGITVVIDDDKEKTPGEKFYIWELKGVPLRIEIGPKELNNNTVYIKRRDTFEGKSVPKDKAVEEVNTLLEKIKNDLHEKALKFLKERIIYTEDLNEAKKILEERAGVVEVPWCGDNNCGLQLQDVTNARVLGIPLDEDKDVSNAKCVMCKKPAKSLLRLAKTY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_SHEHH
Sequence: MTERVRVAITGGSGRMGRTLIEAAKQNGIILLGAAIERAGSTLMGVDAGELAGVGSMNVAITDSLDKAVNDFDVLIDFTSPEASVFHTDWCAKNGKAIVIGTTGFNHAQKEQISAYADQIPIVMAPNMAVGVNLMWKLLEVTAEVMGHYCDIEIIEGHHRYKKDAPSGTALKMGEVIAETLGRDLEKCAVYGREGMTGERDRETIGFATVRAGDIVGEHTALFADIGERLEITHKASSRMTFANGAMRAATWLVEQDAGLYDMQQVLGLKA
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGAM_ECOLI
Sequence: MFNRPNRNDVDDGVQDIQNDVNQLADSLESVLKSWGSDAKGEAEAARSKAQALLKETRARMHGRTRVQQAARDAVGCADSFVRERPWCSVGTAAAVGIFIGALLSMRKS
What are the official names of this protein?
Uncharacterized protein YgaM.
What is the protein family that this protein belongs to?
Belongs to the ElaB/YgaM/YqjD family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DDI1_LEIMA
Sequence: MVQLTIDNARGVTLCRVSLPANATVQQLLLQLTVAKPELRQAQAIRNDVRHVTHRLTPASTTTTTTTSVVSSNAQTLLQAGLVGQGATAETLVVLMAADAPAAASSAAAAAPSPTKAVAAQILDLFGCASASPSAGVRSQASVVPSTMDERQLELQRRIYAQIQQQQIDENLANALEYTPEAFAKVTMLYVPCTINQVLVKAFVDSGAQNSIMNKRTAERCGLMRLVDVRMRDVAVGVGRQEICGRIHMTPVNLAGMYIPFAFYVIEDQAMDLIIGLDQLKRHQMMIDLKHNCLTIDNINVPFLPENDLPALAALGDDENAMHAPRHQDPATTATTASNPAAPVLSEGERQARIEGFMTVSGITDPTQAAELLEAADWNPNVAAALLFDT
What is the function of this protein?
Aspartic protease (PubMed:22933181, PubMed:21266539).
What are the official names of this protein?
Protein DDI1 homolog, DDI1-like protein.
What is the protein family that this protein belongs to?
Belongs to the DDI1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AB23B_ARATH
Sequence: MMRGSRFLLSRASLYHRLRSDHHHHSFSSFIKRSSIQRSPAINAFFTDPSPSPSPVNARVFFFSTSTSTPNQDQTKTASSKKILRTISSYLWMKDNPELRFRVIAALACLIGAKFLNVQVPFLFKLSIDLLSSYSSSTITDSNPYLLAAFATPSSVLIGYGIARSGSSAFNELRTAVFSKVSLRTIRSVSRKVLSHLHDLDLRYHLNRETGALNRIIDRGSRAINTILSAMVFNVVPTILEISMVTGILAYNFGPVFALITSLSVGSYIAFTLVVTQYRTKFRKAMNQADNDASTRAIDSLVNYETVKYFNNEDYEARKYDDLLGRYEDAALQTQKSLAFLDFGQSFIFSTALSTSMVLCSQGIMNGEMTVGDLVMVNGLLFQLSLPLYFLGGVYRETVQGLVDMKSLFQLLEERSDIGDKDTETKLPPLVLRGGSISFENVHFSYLPERKILDGISFEVPAGKSVAIVGSSGSGKSTILRMIFRFFDTDSGNVRIDGQDIKEVTLESLRSCIGVVPQDTVLFNDTIFHNIHYGNLSATEEEVYDAARRAVIHDTIMKFPDKYSTAVGERGLMLSGGEKQRVALARAFLKSPAILLCDEATNALDSKTEAEIMKTFRSLASNRTCIFIAHRLTTAMQCDEIIVMEKGKVVEKGTHQVLLEKSGRYAKLWTQQNSTLEV
What is the function of this protein?
Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins.  Not involved in the export of cyclic pyranopterin monophosphate (cPMP) from mitochondria into the cytosol.
What are the official names of this protein?
ABC transporter B family member 23, mitochondrial, ABC transporter ABCB.23, AtABCB23, ABC transporter of the mitochondrion 1, AtATM1, Iron-sulfur clusters transporter ATM1, Protein STARIK 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NADK1_PROMT
Sequence: MTTNLIWILYRSDSDTAYKETLNCKKIIEGYGKKVLFSEISNETNNINQLFLKSEVLPEITIVLGGDGTVLRAARYLSPKNIPILSFNVGGNLGFLTHDRQILKQETFWERVSNNRFNIQKRMMLEATVFREKNNNENTIKKSFFALNDFYLRSCTDEIAPTCSLALEIDGEAVDRYKGDGLIFSTPTGSTAYSMAAGGPIIHPSLDAIIVSAICPMSLASRPIVVPPESQLVIKPIRGMKQKIKLWLDGSSGCLIEAEDTCLIKKSNHSTSIIILDENHSYYKTITQKLHWASSLNNPNKQ
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase 1, ATP-dependent NAD kinase 1.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPB5_ASFB7
Sequence: MAMQKLFTYIYEFIEYRKMVLLEEKVPYDKFVQMVLNTGFFRINAETLNHGIVSVFIFGANGKYVHHGGDMRTLLTNTLNEKKHYEELILIVDKPVLSKKNILDIIVEQRAANPTIVINIYPYHLFCINIPKVSAIPKHKLITQEEAQEFLGREYLQPQDLMQISASDPPVVWLGGRPGDFVQIERPSETAMHAVVIRFITKSKI
What is the function of this protein?
Component of the DNA-directed RNA polymerase (RNAP) that catalyzes the transcription in the cytoplasm of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase RPB5 homolog, RPB5 homolog.
What is the protein family that this protein belongs to?
Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion. Note=Found in association with viral nucleoid.
Protein: DCD_PARXL
Sequence: MTIKSDKWIRRMAESHKMIEPFAPDQVRVSEDGRKIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEKSFVDFKGDVCIIPPNSFALARTVEYFRIPRSVLTVCLGKSTYARCGIIVNVTPFEPEWEGHVTLEFSNTTPLPAKIYANEGVAQVLFFESDEICETSYADRGGKYQGQHGVTLPRT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: PLCD4_PONAB
Sequence: MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVDTIRNGHDSELLRSLAEELPLEQGFTVVFHGRRSNLDLVANSVEEAQMWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLREEQKERDCTSELALELIDHYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRRILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQSKDKKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAERLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPERPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGETLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKVGISLRPASIFVYICIQEDLEGDES
What is the function of this protein?
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).  DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores.  Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction.  May play a role in cell growth.  Modulates the liver regeneration in cooperation with nuclear PKC.  Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity).
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4, Phosphoinositide phospholipase C-delta-4, Phospholipase C-delta-4, PLC-delta-4.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
Protein: JARD2_MOUSE
Sequence: MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNAQKRQHGEGLAGSLKAVNGLLGNAQAKALGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQDEEDVEEEDDETEDVKATTNNASSSCQSTPRKGKTHKHVHNGHVFNGSSRSAREKEPAHKHRSKEATPGKEKHSEPRADSRREQASGAQPTAASAAASSAKGLAANHQPPPSHRSAQDLRKQVSKVNGVTRMSSLGAGTNSAKKIREVRPSPSKTVKYTATVTKGTVTYTKAKRELVKETKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAASGLKASSRLNPKSCTKEVGGRQLREGLRNSKRRLEEAQQVDKPQSPPKKMKGVAGNAEAPGKKASAASGEKSLLNGHVKKEVPERSLERNRPKRAAAGKNMLGKQAHGKTEGTPCENRSTSQPESSHKPHDPQGKPEKGSGKSGWAAMDEIPVLRPSAKEFHDPLIYIESVRAQVEKYGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLRSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPKTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTESDHHKFHSLPRFEPKNGLVHGVTPRNGFRSKLKEVGRAPLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMNMCFSKEPAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKLEDVVHTLLQGNGTPGLQMLESNVMISPEVLCKKGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYNVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRLLFEAGLHSSARYGSHDGNSTVADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKHGGIENCLNKPTPKRGPRKRATVDVPPSRLPSS
What is the function of this protein?
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:10807864, PubMed:12852854, PubMed:12890668, PubMed:15542826, PubMed:15870077, PubMed:19010785, PubMed:20064375, PubMed:20064376, PubMed:20075857).  Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20064376, PubMed:20064375).  Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20064375, PubMed:20075857).  In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (PubMed:12852854, PubMed:12890668, PubMed:19010785).  Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (PubMed:15542826).  Participates in the negative regulation of cell proliferation signaling (PubMed:10913339).  Does not have histone demethylase activity (PubMed:20064376).
What are the official names of this protein?
Protein Jumonji, Jumonji/ARID domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the JARID2 family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with the PRC2 complex on chromatin.
Protein: MAO1_BACSU
Sequence: MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVGPNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPIRSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAGMPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFEIEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAICRMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPAFVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEINHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK
What is the function of this protein?
Catalyzes the decarboxylation of malate to pyruvate.  Is specific for NAD, cannot use NADP.  Can also catalyze the decarboxylation of oxaloacetate (PubMed:16788182).  Involved in keeping the ATP levels high (PubMed:23136871).
What are the official names of this protein?
NAD-dependent malic enzyme 1, NAD-ME 1, Malate dehydrogenase MleA.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: PCKA_SHEPW
Sequence: MADGSNREYLNLSTGQLVELALARGEGELTANGALVAKTGERSGRSPNDRFIVKEPSSEADIEWGPVNKPFEADAFTALWNRVEAYLADKDTFVSNLEVGASKEHYQPVTVTTEYAWHQLFARNLFIVPTEFNAADKPTWQIINAPGFVCNPERDGTHSDATVILNFAERKVLLAGLKYAGEMKKSMFSVQNFLLPAKGVLPMHCSANVGSDGDTTLFFGLSGTGKTTLSADPKRFLIGDDEHGWAPGGVFNIEGGCYAKCIDLSQKNEPVIWDAIRFGTVLENVVTDENRVPDYTNSTLTENTRAAYPLEHIAQRKEENCGAEPHAVVFLTCDVSGVLPPVSKLTKEQAAYHFLSGYTAKVGSTEMGSTAAIQSTFSTCFGAPFFPRPAGVYAELLMKRIESFGSQVYLVNTGWTGGPHGIGKRFDIPTTRAIVDAIVSGELKDVETEYLEKLNLHVPVAIPGVDSNLLNPINTWEDKQQYAEFAQHLAESFQKNFEKYQVPDSIKNAGPNA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.