PharMolix/UniProtQA huggingface dataset:
Protein: SYL_CHLTE
Sequence: MKYDFSALEKKWQSRWADEQTFASSADQEKPKYYVLDMFPYPSGSGLHVGHLEGYTATDIMARYKRCQGHNVLHPMGWDAFGLPAEQFAIKTGTHPRLTTEKNVASFRETLKSMGFSYDWSREINTTDPNYFKWTQWIFLKLYEKGLAYISEVDVNWCEELKVVLANEEVDEKIADGYTVVRRPLRQWVLKITAYAERLLKDLDEVDWPENVKQMQRNWIGRSEGMEIDFELRCHRTNLRVYTTRPDTLFGATYLVISPEHPMAEKLAIAQQLVAVKKYIEQAKLKTELERTGLQKEKTGVFTGSYAINPANGEALPVWISDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIREVIKSPHDVQERVFDGKESVCVNSANDEISINGLDFKTAFDRMAAWLESKGKGKRKVNYKLRDWVFSRQRYWGEPIPIKHYEDGTMRPETNLPLTLPEVEAYQPTSTGESPLANIESWLYGEDEHGKFRRETNTMPQWAGSCWYYLRFIDPQNSDALVDPSLEQYWMNVDLYIGGAEHAVLHLLYSRFWHKVLYDLGVVSTKEPFQRLFNQGMILGEDNEKMSKSRGNVIPADHVLSTYGADALRLYEMFLGPLDQVKPWNTHGIEGISRFLNKVWRLVWDENTETQKTTEDKPSEAILKRMHKAIKKVTEDTEQLKFNTAISEMMVLVNELHKAGCYSRETTETLLVLLSPFAPHITEELWQALGHAESISGAVWPVFDAKLATDDVLTIAVQVNGKLRGTFEAPAGCTKEEMIESAKKVESVAKFLDGQQIVKEIAVPGKLVNFAVKPQQ
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y33A_METJA
Sequence: MMNGENMDKQTVIGFVVLFCVLELVFYLKKLYQSMALTLAVFGIFSLLFFLLYIPVLSKKAVPYVINYFKPPHQRVREIKVGSDETTDNSIIRLKEKAKTLHPDEGNRISGRSSNSFKDSASCIITIVDDSN
What are the official names of this protein?
Uncharacterized protein MJ0332.1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUSB_AZOSB
Sequence: MSSRMARRRARELALQGVYQWLLSGNSPQVVEAHVEAEAADFDKVDRELFVMLLRGTLDNVGALQDEFSPFIHRPIEELSPIERAILLLGTHELKHNIETPYRVVINEAIELAKAYGGTDGHRFVNGVLDKLAARLRSIEVEAARAKKDAGDGQA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PURT_ALBFT
Sequence: MTTLGTPLSHHATKVMLLGSGELGKEVIIALQRLGVETIAVDRYNHAPGQQVAHHTRTITMSDPALLKALIQAEKPDLVVPEIEAIATPMLEVLEATGVVRVIPTARAARLTMDREGIRRLAAETLGLPTSPYQFCDSFEELQAAIEGGIGYPCIVKPVMSSSGKGQSKISGPADVQKAWDYAMAGGRVSHGRVIVEGFIDFDYEITLLTVRAKGADGQIETHFCEPVGHLQVNGDYVESWQPHPMHPAALERARHIAKTVTDDLGIAVDGQASGLGIFGVELFVKGEQVWFSEVSPRPHDTGLVTLTTQWQSEFELHARAILGLPVNTALRNPGASAVIYGGVDAKGIVFDGVDEALRVPGTDLRLFGKPESFVKRRMGVALAAHADVEQARVNAKLAASKVKPRAA
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: PEBA_PARMW
Sequence: MFDPFLEELQTGIQARGGISVEVPAGLEHNQSQKGSSTIQSWLWQVPGFRRWRVTRLDAGDSLQVLNSVAYPDFDLDHPLMGVDLLWFGARQKLVAVLDFQPLVQDKDYLDRHFDGLKDLNARFPDLNGEETMRSFDPNQYFSSWLLFCRGGSEEADRSLPKAFSAFLKAYWGLHDEASKEPSSISPGDVERLQNAYDVYSAERDPAHGLFTSHFGKEWSDRFLHEFLFPASQPA
What is the function of this protein?
Catalyzes the two-electron reduction of biliverdin IX-alpha at the C15 methine bridge.
What are the official names of this protein?
15,16-dihydrobiliverdin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: FB150_ARATH
Sequence: MTKISDLPRDLAEEVLSRVPVTYLRAIRFTCKKWNTLTKRRSFTKKLIGQEKAEAKVKEFHAIMTLNSRLHLMSVNLDGIHKDENVESSIKQKGKLISLTVADPDRIVISQVYHCDGLLLCITNEINSRLVVWNPYSGQTRWIEPRTSYREWDIYALGYESKNNAKRSYKILRYLDAYEDMGDMSVEPRTRVCEFEIYSLDTNSWKVIEVTTDWDLCFLHRGVTLKGNTYWFAREKIPPPPRERVIEDIPLGEAEINVEIPSFLLCFDFTIEKFGSRLPLPFRPCVDDTITLSSVREEKLAVLYQRWDITWTGIWISNKIEPNAVSWSKLFFPMGRIRPLEAASGTFFVDEENKLVVLFDKGESILNPTRNTAYIVGEDGYIKPVDLGESVHKYCFPLACSYVPSSVQI
What are the official names of this protein?
F-box protein At3g17320.
Protein: ZCIS_ARATH
Sequence: MAVYHLLLSSPPSLLLLPPSPRRPNLTLIRRIPAHPRLGNSTSLLSSSSPVIRKILVRSTLREDQPIASDSESSPTLLIGEDSAAFELGKQKLVSWVYFGVVLGVVLFILNVVWIDNSTGFGKSFIDAVSNISGSPEVAMLMLILIFAIVHSGLASLRDIGEKLIGERAFRVLFAGISLPLAMSTIVYFINHRYDGSQLWQLQGVPGVHEAIWVANFVSFFFLYPSTFNLLEVAAVDKPKMHLWETGIMRITRHPQMVGQIVWCLAHTLWIGNTVAASASLGLIAHHLFGAWNGDRRLAKRYGEDFESIKKRTSVIPFAAIFEGRQVLPEDYYKEFVRLPYLAITALTVGAYFAHPLMQGASFRLHW
What is the function of this protein?
Isomerase involved in the biosynthesis of carotenoids.  Catalyzes the cis- to trans-conversion of the 15-cis-bond in 9,15,9'-tri-cis-zeta-carotene.
What are the official names of this protein?
15-cis-zeta-carotene isomerase, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: TBX5_XENLA
Sequence: MADTEEAYGMPDTPVEAEPKELQCEPKQDNQLGASSKTPTSPPAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFSETDFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVSSNHSPFSQETRNITGSSTLNSQYQCENGVSSTSQDLLPSSSAYTSLPHESGTIYHCTKRKVSEEPAEHSYKKPYMDTSPSEEDPFYRSGYPQPSSSSSSTTSFRTESAQRQACMYASSAPATEPVPSIEDISCNSWSSVPSYSSCTVGGGMQPMERLPYQHFSAHFTSSSLMPRLSNHAGTQPSDSHSMFQHQSSHQAIVRQCNPQSGLQQSSALQPTEFLYPHSVPRTISPHQYHSVHGVGMVPDWNENS
What is the function of this protein?
DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:10079235).  May bind to the core DNA motif of promoters (By similarity).
What are the official names of this protein?
T-box transcription factor TBX5, T-box protein 5.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus.
Protein: DCTA_XANC8
Sequence: MHISKPAGPLPAPVPFYRQLYFQVVVAIVLGALLGHFEPAFAESLKPLGDAFIKLVKMIIAPVIFLTIVTGIAGMTHLKTVGRVFAKSMTYFLFFSTLALIVGMVVAHVVQPGAGMNINPAELDQSAVNTYVQKSHELSLVGFLMDIIPATLISAFVDGNILQVLFVAVLFGIALALVGERGRPVLSFLEALTAPVFRLVHMLMKAAPIGAFGAIAFTIGKYGVESLVNLAWLVGSFYLTSLFFVLVILGIVCRLCGFSVLKLIRYLKAELLLVLGTSSSESALPSLMEKMEKAGCEKSVVGLVVPTGYSFNLDGTNIYMTLAALFIAQATNVDLTLGQQITLLAVAMLSSKGAAGVTGAGFITLAATLSVVPDVPVAGMALILGVDRFMSECRSLTNFIGNAVATVVVSRWENALDRDQLSLALDGRAPPLQAPVPPPDAVAPVSAR
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y0430_BRAHW
Sequence: MRKTVKIITSLVLIACLFLLASCANKGSSSSGDATTLKVAVMPFLNSVPIEYMINNKLDEKYGFKIETVYFPSGGPMNEALGAGLWEVGTLSAASVYSLANYNAHVVADIGHSEGGIEVLVNPDSDILTVKGVNKDFPEVYGDAATLKGKTIAVPTGTISHLNVIHWLRAINVDPNTVNIVHMEFPQAYQALKAKKIDAAALNPPTSFSAEADGMKIVSSLTTLNIPQYDSIIVSDEAFNNKKDTIVLYIKAFLEACDALQADPNMAAQELLNWYTKNGSTSTLEACQSEVQTRPFVTTEEIKNIKTGDSVRITADFFASQSLITEDKLTVVDQNVDTELLGKALN
What is the function of this protein?
Probably part of an ABC transporter complex.
What are the official names of this protein?
Putative ABC transporter periplasmic binding protein BHWA1_00430, P-H7.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein SsuA/TauA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RSMA_THEKO
Sequence: MRDRLFSIIYKYNLHPNRDLGQNFLIVPDIIERNIERAEVGEKDTVLEIGPGLGVLTDPLSKRAGKVYAIEKDCRIVEILRREYNWPNVEIIEGDALKVEWPEFNKMVSNLPYQISSPVTFKLLSREFERAVLIFQLEFAERMVAKPGDKNYSRLSLMVRAKARAELVERIGKGAFWPRPKVDSAVVVLEPKPPEERIDLNENLVKALFQHRRSTVSAALKKSAHMLGLSKDKARELRQVFSRVPHSERRVFQLSPEDVLEIEEFLKKEGVIESYPASP
What is the function of this protein?
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Probable ribosomal RNA small subunit methyltransferase A, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_HELP2
Sequence: MSMQTAPIKKTTLNHLQAKKNQEKIIAITAYDALFAQIFDPLVDVILVGDSLNMSFFNQNDTLSASVEMMLYHTKAVCAGAKTPFIITDMPFGSYKDEKTALKNAIRVYKETQASAIKLEGGKEKAKLVKTLTDEGVIVVGHIGLMPQFVRLDGGYKIKGKNEEQQKKLLEDALSLEEAGVGLLVLEGITTPIAQKITQKIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYLKGKELVQNAIKQYADDVKKGNFPNELESYH
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYRM4_BOVIN
Sequence: MAASSRAQVLDLYRAMLRESKRFGAYNYRTYAIRRIRDAFRENKNVKDPVEIQALVNKAKRDLGIIRRQVHIGQMYSTDKLVIENQEKPRA
What is the function of this protein?
Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity).  The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis.  This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner.  Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly.  Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).  May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (By similarity).
What are the official names of this protein?
LYR motif-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus.
Protein: HS105_BOVIN
Sequence: MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKSQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEEHLFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDAKLVEYFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRAQFEELCADLLQKIEVPLYLLMEQTQLKVEDVSAVEIVGGTTRIPAVKEKIAKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWSHDSEDAEGVHEVFSRNHAAPFSKVLTFLRSGPFELEAFYSDPQGVPYPEAKIGRFIVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKIPAEENEVSSLEADMDCQNQRPPENPDAEKNIQQDNNEAGTQPQVQTDGHQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQDHQKFLRLLTETENWLYEEGEDQAKQAYVDKLEELMKIGTPIKVRFQEAEERPKIFEELGQRLQHYAKIAADFRNNDEKYNHIDESEMKKVEKSVNEMMEWMNNVMSAQAKKSLDQDPVVCAQEIRAKIKELNNNCEPVVTQPKPKIESPKLERTPNGPSTDKKEEDLDGKNNFSAEPPHQNGECYPNEKSSINMDLD
What is the function of this protein?
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release.  Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly.  Inhibits HSPA8/HSC70 ATPase and chaperone activities.
What are the official names of this protein?
Heat shock protein 105 kDa, Heat shock 110 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQFH_ECOLI
Sequence: MINQVSVYRQPPVLSGCRQVKTI
What are the official names of this protein?
Protein YqfH.
Protein: KDPA_YERPE
Sequence: MVASGFLLIASFMLVLFVLSRPLGGFLARLIEGEPFSALQKVEAGLWRCSGVKNAEMNGWQYALAILCFNLLGIVLLFVLLMTQGSLPLNPEHLPGMSWHLALNTAVSFVTNTNWQAYSGENTLSYLSQMAGLTVQNFLSAATGIAVAFALIRAFARHSATTLGNAWVDLVRITLYVLLPIALIIALIFVSQGVLQNLDDYLHITTLEGVQQTLPMGPVASQEAIKVLGTNGGGFFGANSAHPFENPTAFSNFVQMLAIFLIPCALCFAFGQVVGDNRQGHALIWAMSLIFIVAVVVVMYAELAGNPHLSPLGADSNSNMEGKESRFGILATSLYAVVTTAASCGAVNAMHDSFTALGGMIPLWLMQIGEVVFGGVGSGLYGMLLFVLLTVFIAGLMIGRTPEYLGKKIDVFDMKMTALAILVTPTIVLLGTALALCTEAGRAGILNPGAHGFSEVLYALSSAANNNGSAFAGLSVNTPFYNLLLAAAMFIGRFGVILPVLAIASSLVAKKRQPAGNGTLPTGGLLFIGLLIGTVLLVGALTFIPALALGPVAEHLQVWLAH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1028_XANOM
Sequence: MDLPDVTAVQNESRQLALASSAAELHGGLCGWLSGGGADSADWLARILADTGQVAPKQGGALDQLRQATVAQMEDRDFAFELLLVEDGAPLAARTDALFDWCRAFLGGFGLAAQQRPALSEEGEEALQDLARLAQASSDDFDAADEDDTALAEIEEFVRVAVLLLHGDCVMGPRFRQRLN
What are the official names of this protein?
UPF0149 protein XOO1028.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: PSA_SALAI
Sequence: MAMQFYASPEQIMRDRSELARKGIARGRSAVVLSYAGGVLFVAENLSSALHKVGEIYDRIGFAAVGRYNEFENLRRAGVRMADLNGLSYDRRDVTGRALANAFAQTLGAIFTEQSKPFEVEICVAQVGATTADDELYRLTYDGSVNDEPGRMAMGGQAEAITGVLKSNHRPDMSLGDAVKVAVQALGSVGGEGGAARTIAADQLEVAVLDRGRVGRTFRRVTGAALTVLLDDGAAGQPPSSSDTDTSAAEARKPTASAGSADLEGPEPERPDS
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PrcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_YPOMA
Sequence: MATWNNLNLQNGASPLMEQIIFFHDHTLIILIMITILVGYLMINLFFNKYINRFLLEGQMIELIWTILPAITLIFIALPSLRLLYLLDELNNPLITLKSIGHQWYWSYEYSDFNNIQFDSYMIPSKEMKFNEFRLLDVDNRIILPMNNQIRIMVTATDVIHSWTVPSLGVKIDANPGRLNQTNFFINRPGLFYGQCSEICGANHSFMPIVIESISINNFIKWINNYSS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RDRP_CMVFN
Sequence: MAFPAPAFSLANLLNGSYGVDTPEDVERLRSEQREEAAAACRNYRPLPAVDVSESVTEDAHSLRTPDGAPAEAVSDEFVTYGAEDYLEKSDDELLVAFETMVKPMRIGQLWCPAFNKCSFISSIAMARALLLAPRTSHRTMKCFEDLVAAIYTKSDFYYSEECEADDAQIDISSRDVPGYSFEPWSRTSGFEPPPICEACDMIMYQCPCFDFNALKKSCAERTFADDYVIEGLDGVVDNATLLSNLGPFLVPVKCQYEKCPTPTIAIPPDLNRATDRVDINLVQSICDSTLPTHSNYDDSFHQVFVESADYSIDLDHVRLRQSDLIAKIPDSGHMIPVLNTGSGHKRVGTTKEVLTAIKKRNADVPELGDSVNLSRLSKAVAERFFISYINGNSLASSNFVNVVSNFHDYMEKWKSSGLSYDDLPDLHAENLQFYDHMIKSDVKPVVSDTLNIDRPVPATITYHKKSITSQFSPLFTALFERFQRCLRERIILPVGKISSLEMAGFDVKNKHCLEIDLSKFDKSQGEFHLLIQEHILNGLGCPAPITKWWCDFHRFSYIRDRRAGVGMPISFQRRTGDALTYFGNTIVTMAEFAWCYDTDQFEKLLFSGDDSLGFSLLPPVGDPSKFTTLFNMEAKVMEPAVPYICSKFLLSDEFGNTFSVPDPLREVQRLGTKKIPYSDNDEFLFAHFMSFVDRLKFLDRMSQSCIDQLSIFFELKYKKSGEEAALMLGAFKKYTANFQSYKELYYSDRRQCELINSFCSTEFRVERVNSNKQRKNYGIERRCNDKRRTPTGSYGGGEEAETKVSQTESTGTRSQKSQRESAFKSQTIPLPTVLSSGWFGTDRVMPPCERGGVTRV
What is the function of this protein?
RNA-dependent RNA polymerase which replicates the viral genome composed of 3 RNA segments, RNA1, RNA2 and RNA3.
What are the official names of this protein?
RNA-directed RNA polymerase 2a, protein 2a.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: BIOD_MYCLB
Sequence: MTVVVVTGTDTGVGKTVACAALACHARQAGIEVAVCKPVQTGTQIGDDDLAEVARLSGVTELTGLVRYPQPLAPAAAAEHAGMALPTREQLLELIAGLDRPGRLILVEGAGGLLVELADASATLRDLAVELGALALVTVSVELGTLNHTALTLEALTTRGVACAGLVIGSWTGRPGAVQISNRSALARLAPMRATLPAGAGSMDATDFAAMSAAAFDRDWVTTLVH
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_STRA5
Sequence: MLDLKRIRTDFDVVAKKLATRGVDQETLTTLKELDIKRRELLIKAEEAKAQRNVASAAIAQAKRNKENADEQIAAMQTLSADIKAIDAELADVDANLQSMVTVLPNTPADDVPLGADEDENVEVRRWGTPREFDFETKAHWDLGESLGILDWERGAKVTGSRFLFYKGLGARLERAIYSFMLDEHAKEGYTEVIPPYMVNHDSMFGTGQYPKFKEDTFELADSPFVLIPTAEVPLTNYYRDEIIDGKELPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYQELEKMTANAENILQKLNLPYRVITLCTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNTEDFQARRAQIRYRDEVDGKVRLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEVLRPYMGNIDIIKPN
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_STRP7
Sequence: MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIQINEEQGQFGFDRVKELVDTYKVERFVVGLPKNMNNTSGPRVEASQAYGAKLEEFFGLPVDYQDERLTTVAAERMLIEQADISRNKRKKVIDKLAAQLILQNYLDRKF
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIX2_MOUSE
Sequence: MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENSNSSSHNPLASSLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHSLQDSILNPMSANLVDLGS
What is the function of this protein?
Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach.  During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation.  Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4.  Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1.  During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation (PubMed:20515681).  During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1 (PubMed:19660448).  During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway (PubMed:18321982).  May also be involved in limb tendon and ligament development (PubMed:7720577).  Plays a role in cell proliferation and migration (By similarity).
What are the official names of this protein?
Homeobox protein SIX2, Sine oculis homeobox homolog 2.
What is the protein family that this protein belongs to?
Belongs to the SIX/Sine oculis homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURA_LIGS1
Sequence: MSSVVVVGSQWGDEGKGKITDFLSQNAEVIARYQGGDNAGHTIAFDGKTYKLRLIPSGIFYSDKISVIGNGVVLNPKSLVTELKYLHDNGVSTDNLRISNRAHVILPYHIVLDGLQEAAKKDNKIGTTNKGIGPAYMDKAARVGIRVADLLEKDTFEEKLRTNLEEKNRLFEKMYGHEPLKFEDIFEEYYEYGQELKDYVTDTSVILNDALDSGKRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPAKIDKVVGACKAYTSRVGDGPFPTELHDEIGDHIREVGHEYGTVTKRPRRIGWFDSVVMRHSKRVSGLTNLCLNCVDVLTGLDEIKICTAYELNGEKIYHYPASLKELSACKPVYETLPGWKEDITNCKTLEDLPENARNYIHRIQDLVGVKVSTFSVGPDREQTNVLDNVWAHI
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNT_PSEAB
Sequence: MSEDNFDDEFDGSLPSGPRHPMARRFRGYLPVVVDVETGGFNSATDALLEIAATTVGMDEKGFLFPEHTYFFRIEPFEGANIEPAALEFTGIKLDHPLRMAVQEEAALTEIFRGIRKALKANGCKRAILVGHNSSFDLGFLNAAVARTGIKRNPFHPFSSFDTATLAGLAYGQTVLAKACQAAGMEFDNREAHSARYDTEKTAELFCGIVNRWKEMGGWMDDDD
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.