PharMolix/UniProtQA huggingface dataset:
Protein: APX_PSEMZ
Sequence: EGLLQLPSDK
What is the function of this protein?
Plays a key role in hydrogen peroxide removal.
What are the official names of this protein?
L-ascorbate peroxidase, cytosolic.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ascorbate peroxidase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_RICPU
Sequence: MVDLKTKAFDISQNFTISLDGPAASGKGTIGLILAKKFSLKYFQSSIVYRQLAFDCISQKIDVTDIDAVIALSKELKLDNNFDLENENIGNIASQIAVISEIRNNLNKYLINLVKTTPRMIMEGRDIGTVVAPDADLKIFITANPQIRAERRYKQLQAKGKTCILDEILRQIILRDKRDKERKAAPLLPASDALIIDTSKLSAMEVVEEVTNYIKNKIT
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPE68_MYCTO
Sequence: MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW
What is the function of this protein?
Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M. tuberculosis infection.  Together with PE35, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2).
What are the official names of this protein?
PPE family immunomodulator PPE68.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell membrane. Cell surface.
Protein: EEDA_XENLA
Sequence: MSEASGRAAGNEMPAKKQKLSSDENSNPELSGDENDDSVSIESGTNTERPDTPTNAANAPGRKAWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHPQGDIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSLRMKTAIKESYEYNPSKTNRPFVSQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEAEDPHKAKCTTLTYPKCASAVRQTSFSRDSSILVAVCDDATIWRWDRLR
What is the function of this protein?
Polycomb group (PcG) protein.  Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity).
What are the official names of this protein?
Polycomb protein eed-A, Xeed-A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ESC family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NDUS2_PROWI
Sequence: MALEKIITAPKYKNFTINFGPQHPAAHGVLRLVLEMNGEVVQRSDPHIGLLHRGTEKLIEYKNYLQALPYFDRLDYVSMMCQEHAYSLAVEKLLNISKDIPLRAQYIRVLFSEITRILNHLLAVTCHAMDVGALTPFLWGFEEREKLMEFYERVSGARMHAAYIRPGGVALDLPLGLCEDIYKFSKQFASRIDEIEEMLTSNRIWKQRLVDVGVVSAEQALDWSFSGVLLRGSGIAWDLRKTQPYEVYDRMKFNIPVGTRGDCYDRYLIRVQEMRESLRIVMQTINEMSKGIIRLDDRKITPPTRDQMKQSMESLIHHFKFYTGGFVVPAGETYTAVEAPKGEFGVYLVSNGTSKPYRCKIRAPGFAHLQGLDFMARNHMLADVVTIIGTQDIVFGEVDR
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).  Component of the iron-sulfur (IP) fragment of the enzyme.  Component of the iron-sulfur (IP) fragment of the enzyme.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 49 kDa subunit, NADH dehydrogenase subunit 7.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: AAEA_SALG2
Sequence: MKTLTRKLSRTAITLVLVILAFIAIFRAWVYYTESPWTRDARFSADVVAIAPDVAGLITHVNVHDNQLVKKDQVLFTIDQPRYQKALAEAEADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDPERTVIRAPADGWVTNLNVYAGEFITRGSTAVALVKKNSFYVQAYMEETKLEGVRPGYRAEITPLGSNRVLKGTVDSVAAGVTNASSTSDAKGMATIDSNLEWVRLAQRVPVRIRLDEQQGNLWPAGTTATVVITGKQDRDASQDSFFRKLAHRLREFG
What is the function of this protein?
Forms an efflux pump with AaeB.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeA, pHBA efflux pump protein A.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ADRB1_MELGA
Sequence: MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQHQA
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  This receptor binds epinephrine and norepinephrine with approximately equal affinity (PubMed:18594507).  In dorsal pons neurons, involved in the regulation of sleep/wake behaviors (By similarity).
What are the official names of this protein?
Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor, Beta-T.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity).
Protein: Y4JA_SINFN
Sequence: MPGRHVTDHQMRLFMKYRQTHSVEVAAAKASISRATAFRMEKEQRLPSQNKPPRGRRRPDPLEHIFDAEVVPLLKAAPGIRAVAVYDEMLRRHPELPEGIRRTLERRIRSWRAVHGEAQEVIFRQTHEPGRLGLSDFTDMGSLSVTIAGQPLDHLLYHFRLVWSGFEHAHVILGGESFVALAEGLQNALWSVGGSPLYHRSDSLSAAFRNLDADAKVDLTNRYEELCAHYRMTPTRNNKGVAHENGSIESSHGHLKNAVRDALLMRGTRDFDDLRSYRAFIDEIVSRRNAAHGKRIDAERPHLQVLPERRTTDFEEVVVTVSRTGGFALRKVFYTVPSRLIGHRLRVRLFDDRLDVFIGGTHLLTLPRGRAHASGKHDQVVNYHHVIHSLRKKPMALLNLVYRDKLFPRPEYRRAFDALIEQLPDRQACKITVELLALAHDRGCERELAEELARTLDARKLPDLMALRAIFGPDPDQLPTVHVQLASLNSYEALMGSAYAGEAA
What are the official names of this protein?
Uncharacterized protein y4jA/y4nE/y4sE.
Protein: NU2C1_DAUCA
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFDGSLIVPECILIFGLILLLMIDSTSDQKDIPWLYFISSTSLVMSITALLFRWREEPVISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATMKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLETLAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVLIGLLTSVVSIYYYLKIIKLLMTGRTQEITPHVRNYRRSPFRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 A, chloroplastic, NAD(P)H dehydrogenase, subunit 2 A, NADH-plastoquinone oxidoreductase subunit 2 A.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CCA_HAEIN
Sequence: MKVYLVGGAVRDQLLGLPVKDRDWIVVGADPATLLSLGYQQVGKDFPVFLNPKTKEEYALARTERKSSAGYTGFICDFSPTITLEQDLIRRDLTINAMAQSEDGEIIDPYGGKQDLENRILRHISPAFSEDPLRVLRVARFAARYHSLGFKIASETLALMAELAQSGELQHLTAERIWLETEKALNEKNPEIYFETLHKTGALSVLFSEIDALYGVPNPVKHHPEVDSFIHTMLVLKQAVNLTENNPILNKSAVRFAAICHDLGKALTPQNILPHHYGHEQAGIKPTRSLCKRLKVPSYFQELAELTCEFHTHIHKAFELRAETVITLFNRFDVWRKPQRFQEFLQVCLADTRGRTGFETKDYPQIDYINQLLHAANEVDVQQVIADGFEKQAIKNELTKRRILAVKQTKTNYPTN
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: HARS1_MESAU
Sequence: MASPALEELVLNSRHRLVRGLKQQKASADQIEEEVAKLLKLKAQLGHDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIICCFKRHGAEVIDTPVFELKETLMGKYGQDCKLIYDLKDQGGELLSLRYDLTVPFGRYLAMNNLTNIKRYHIAKVYRRDNPAMTRGRYLNSITVDFDIAGQFDPMIPDAECLKIMCEILSSLQIGKFLVKVNDRRILDGMFAVCGVPDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGEVCLVEQLLQDPKLSQNKQAVEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYVAVLLQMPTGAGEEPWCGQCGCWRRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKVRTTETQVLVASAQKKLAGGETKACLQLWDAGIKAELLYKKNPKLLNQLQYCEETGIPLVAIIGEQELKDGVIKLRSVASREEVDVRREDLVEEIRRRTNQPLYVC
What is the function of this protein?
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP).  Plays a role in axon guidance.
What are the official names of this protein?
Histidine--tRNA ligase, cytoplasmic, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_XANC5
Sequence: MNASNPCRRFPRSARVRTRAQYTIVFDTARRTSDPLLSLHWRTGDTPPRLGMAVSRKVDTRAVGRNRIKRVLRDAMRHLLPELAGGDYVIVARSAAAKATNPQIRDAFVRLLRRAGALPLPAAPGTMPPARTVRPSSPSPTEPEL
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: PEA15_CRIGR
Sequence: MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA
What is the function of this protein?
Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis.  Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity).  Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade.  Inhibits RPS6KA3 activities by retaining it in the cytoplasm.
What are the official names of this protein?
Astrocytic phosphoprotein PEA-15, 15 kDa phosphoprotein enriched in astrocytes.
Protein: M3H2_BOMMX
Sequence: MNFKYIVAVSFLIASAYARSVQNDEQSLSQRDVLEEESLREIRGIGGKILSGLKTALKGAAKELASTYLHRRRTAEEHEVMKRLEAVMRDLDSLDYPEEASERETRGFNQDEIANLFTKKEKRILGPVLSMVGSALGGLIKKIG
What is the function of this protein?
Maximin-H2 shows antibacterial activity against both Gram-positive and Gram-negative bacteria.  It shows also antimicrobial activity against the fungus C. albicans.  Shows strong hemolytic activity.
What are the official names of this protein?
Maximins 3/H2.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CBPYA_ASPFU
Sequence: MRVLPATLLVGAATAAAPPFQQILGLPKKSADTLAKPLHDLQEQLKTLSGEARHLWDEVASHFPNNMDHNPVFSLPKKHTRRPDSHWDHIVRGADVQSVWVAGASGEKEREIDGKLEAYDLRVKKTDPSALGIDPGVKQYTGYLDDNENDKHLFYWFFESRNDPKNDPVVLWLNGGPGCSSLTGLFLELGPSSINEKIKPIYNDFAWNSNASVIFLDQPVNVGYSYSGAAVSDTVAAGKDVYALLTLFFKQFPEYAKQDFHIAGESYAGHYIPVFASEILSHKKRNINLKSVLIGNGLTDGLTQYDYYRPMACGEGGYPAVLDESSCQSMDNALPRCKSMIESCYNTESSWICVPASIYCNNALLGPYQRTGQNVYDIRGKCEDSSNLCYKGMGYVSEYLNKREVREAVGAEVDGYESCNFDINRNFLFHGDWMKPYHRLVPGLLEQIPVLIYAGDADFICNWLGNKAWTEALEWPGQKEYAPLPLKDLVIEENEHKGKKIGQIKSHGNFTFMRLYGAGHMVPMDQPEASLEFFNRWLGGEWF
What is the function of this protein?
Vacuolar carboxypeptidase involved in degradation of small peptides.  Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).
What are the official names of this protein?
Carboxypeptidase Y homolog A, Carboxypeptidase 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: BETI_PECAS
Sequence: MPKVGMQPIRRQQLIEATLAAINDVGMHDASIVQIARRAGVSNGIISHYFRDKNGLLEATMRYLISHLGLAVKSRLLNLTENTPRARLRAIVQGNFDDSQTNSAAMKTWLAFWASSLHSPMLHRLQQVNDRRLYSNLSVEFSRCLPKDKARIAAKGVAGLIDGLWLRGALSHNVFNCEEALSITYDYIDQQLTHA
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: ODR4_MOUSE
Sequence: MGRTYIVEETVGQYLSSINLQGKPFVSGLLIGQCSSQKDYVILATRTPPKEEQNDKVKQPRAKLDNLDEEWATEHASQVSRMLPGGLVVLGIFIITTLELADDFQNALRRLIFSMEKSMSRKRLWDVTEDEVSERVTLHICSSTKKISCRTYDVQDPKSSARPADWKYQSRVSASWLSLDCTVHVNIHIPLSATSVSYTLEKNTKSGLTRWAKQIENGVYLINGQVKGNDCDLLEGQKKSRGNTQATAHSFDVRVLTQLLLNSDHRSTATVQICSGSVNLRGNVKCRAYIHSNRPKVKDAVQAVKRDILNTVADRCEILFEDLLLNEIPEKKNYELPQRVFVPLPGSTVMLCDYKFGDESAEEIRDHFSEMLDHEIQIEDLEIAEEVNTACMTSSVNSEASLTNTSEEQPEQPKKTIGVKIQQNIGVIAALAVAVLAAGISFHYFSD
What is the function of this protein?
May play a role in the trafficking of a subset of G-protein coupled receptors.
What are the official names of this protein?
Protein odr-4 homolog, mODR-4.
What is the protein family that this protein belongs to?
Belongs to the ODR-4 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MT2C_ORYSI
Sequence: MSCCGGNCGCGSGCQCGGGCGGCKMFPDVEATATTKTFVLAAPSNKASSGGMEMAVESGENGGCGCNTCKCGTSCSGCSCCSCN
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.  Acts as reactive oxygen species (ROS) scavenger in the cytosol.  Possesses superoxide anion and hydroxyl radical scavenging activities in vitro.  Plays a role during root development, lateral root initiation and seed embryo germination, possibly by regulating levels of cytokinin.
What are the official names of this protein?
Metallothionein-like protein 2C, Class I metallothionein-like protein 2C, OsMT-I-2c, OsMT2b.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ZAPD_COXBU
Sequence: MVATTITYEQPLNEPMRICLRLEHLFRQLHEHIREPAPAASHLAMLALLKALNVIDRPDLKTKLTQTLTQQTSTLLQLKHSPEVDNHKLQGLLDTLDRYVTHLHQTTRKIGEPLRENAFLTQIRSHLYNPAGPCNFTTPAYALWLQQPSENRINDLQNWAKEFEPLINIVNAILQIIRESTSPQNIVARQGFYQQMLNATSPCQLIQLILPIEKNIYPEICAGKHRLVIRFLPLDVNNNENTKQIAEEISFKLNCCRI
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: ABHD8_XENLA
Sequence: MLTSIAERIMYCLTGKTPNSVGPVETSETSDGYDFLEVKPGRVLRVRHILPSCPGDREEEELFEEKNGGQGLVHCKRRITVYRNGQLVIENLGATLRSEILHCRNGNLEPAGTLEVELSDFTSTGNEGGGKESDVPPGKRRKRKPKKVIMVDCQRQVKCCKGTHSDVVLFFIHGVGGSLDIWKEQLDFFSKLGYEVVAPDLVGHGASTAPQIGAAYTFYALAEDMRCIFKRYAKKRNILVGHSYGVSFCTFLAHEYPDLVHKVVMINGGGPTALEPSLCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLREGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPILLVHGMHDKFVPLDEDQRMAEILLITFLKIIEEGSHMVMLECPETVNTLLHEFFLWQPETQNTTAEDTGNE
What are the official names of this protein?
Protein ABHD8, Alpha/beta hydrolase domain-containing protein 8, Abhydrolase domain-containing protein 8.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: TBA3_HORVU
Sequence: MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPGDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVNEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPSVVPGGDLAKVQRAVCMISNSTSVVEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEFDEGEDGDEGDEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-3 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: GCSP_NEIMA
Sequence: MKLSELFNPNEFAARHLSFGDEAALLAAVDEKSMDEFVGNTVPQSIRMPSELDLPEALTEADALAKLKGIASKNMINKSYIGLGYYPTRVPNVILRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGFPVAGASLLDEATAAAEAMAMAHRVGKVKSERFFVDERVYPQTLDVMKTRAKYFGFELVVGDFAQADEGEYFGALFQYVGKDGDVQDLQDVIGRLKAKGTIVAVAADIMSLVLLKSPAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDEFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRREKATSNICTAQALLANLAGMYAVYHGPKGVKRIADRIHALASAFADALVSDGLNVVHKVFFDTVTVDFGNKEKADQVFAAALESGYNLRRVNDTQVAAAFHETSACEDLVDLYRAFTGKDTFAFADDVKGRLNAELLRQDDILQHPVFNSYHTEHEMLRYLKKLEDRDLAMNRSMISLGSCTMKLNATAEMLPITWAEFSDIHPYAPEAQTAGYRELLADMENSLKAITGFDAISLQPNSGAQGEYTGMLSIRRYQEAQGEAHRNICLIPKSAHGTNPATAAMLGLKVVVVDTDEHGNVNIDDLKAKAEQHRDALSAIMITYPSTHGVYEEGIRDICRIIHENGGQVYMDGANLNAQIGIMQPAEVGADVLHMNLHKTFCIPHGGGGPGMGPIGLKAHLAPFAPGHTLTDTHSASAGQTAVAAAAYGSASILPITWMYLTMMGKQGMEQATRWALLNANYVAKRLSEDYPILYTGKNGRVAHECIVDLRPLKAESGITETDIAKRLMDYGFHAPTVSFPVAGTLMIEPTESESKAELDRFIATLKSIRREVQKVIDGEWPKDDNPLVNAPHTAADITGNWAHPYSREEAVFPLPFVREHKFWPFVNRVDDVYGDRNLVCSCPPMENYED
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: PTH_STAEQ
Sequence: MKCIVGLGNIGKRFELTRHNIGFEVVDDILERHQFTLDKQKFKGAYTIERLNGEKVLFIEPMTMMNLSGQAVAPLMDYYNVDVEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMSVPDYVLQKFSKEEMIIMEKVIEHSARAVESFIESSRFDHVMNEFNGEVK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_LEPIN
Sequence: MSTEALLEQIGKLTLVEAADLVKKMEDKFGISAAAPVAVAAVGAAPAGAGAAEEASTFNVILKGFDSAKKIEVIKLVREITGLGLADAKGLVEAGGKAVKEGVAKAEADDLKKKFEGAGAQIELKAS
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: FRDA_ECOLI
Sequence: MQTFQADLAIVGAGGAGLRAAIAAAQANPNAKIALISKVYPMRSHTVAAEGGSAAVAQDHDSFEYHFHDTVAGGDWLCEQDVVDYFVHHCPTEMTQLELWGCPWSRRPDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLQFPQIQRFDEHFVLDILVDDGHVRGLVAMNMMEGTLVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGLPGSGILMTEGCRGEGGILVNKNGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRKGNTISTPRGDVVYLDLRHLGEKKLHERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEQATERAATAGNGNEAAIEAQAAGVEQRLKDLVNQDGGENWAKIRDEMGLAMEEGCGIYRTPELMQKTIDKLAELQERFKRVRITDTSSVFNTDLLYTIELGHGLNVAECMAHSAMARKESRGAHQRLDEGCTERDDVNFLKHTLAFRDADGTTRLEYSDVKITTLPPAKRVYGGEADAADKAEAANKKEKANG
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used during anaerobic growth, and succinate dehydrogenase is used during aerobic growth.  The QFR enzyme complex binds 2 quinones in or near the membrane; 1 near the [3Fe-4S] cluster (QP is proximal to the [3Fe-4S] cluster, on the cytoplasmic side of the membrane) while QD (the distal cluster) is on the other side of the membrane.  It is not clear if both of the quinol-binding sites are functionally relevant (PubMed:10373108, PubMed:11850430).
What are the official names of this protein?
Fumarate reductase flavoprotein subunit, Quinol-fumarate reductase flavoprotein subunit, QFR flavoprotein subunit.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PUR2_METMP
Sequence: MKVLLIGGGAREHAIAMALKKNELVELYTLMKNKNPGIYALSEEVSFNSETDVPAIKEFAEKIKPEIAVIGPESPLGVGASDLLEEMGIPTVGPKKLPAQIETSKEFMRNLFKKYEIDGSLKYAAFNDYGTELEGFIDEMTSLGKDVVVKPAGLTGGKGVKVVGEQLKDNEEAKIYAKEVFDKSIGGGKIIIEEKLVGVEFTLHGFVDGENIVFMPAVQDHPHAYNNDEGPITGGMGSYSCPNHGLPFLSEEMLDKAEKIMEKTVNSINLEVGPYKGFLYGQFMLTADGPKIIEYNARFGDPEAMNLLPILKTDFLDVCFAIAEGKLDKINIEFENKATVCKYVVPNGYPIDPVRNKELAVDEKAIEDANAILFYASINEENGKLYITGSRSAAVVGISENIEEAEKIAQKAIENFKGEVYYRSDIGTLDLIKKRVERVKKLAK
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: PUR7_STRP3
Sequence: MTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVATHYIEQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGRVLETPIVEFYYKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINELLKCWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.