PharMolix/UniProtQA huggingface dataset:
Protein: LGG2_CAEEL
Sequence: MSGNRGGSYISGIVPSFKERRPFHERQKDVEEIRSQQPNKVPVIIERFDGERSLPLMDRCKFLVPEHITVAELMSIVRRRLQLHPQQAFFLLVNERSMVSNSMSMSNLYSQERDPDGFVYMVYTSQPAFG
What is the function of this protein?
Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes) (PubMed:26687600).  When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion (PubMed:26687600).  Less effective at promoting membrane fusion than lgg-1 (PubMed:26687600).  Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation (PubMed:26687600).  In particular binds to components of an atg-5-lgg-3-atg-16 complex to regulate autophagosome formation and cargo sequestration (PubMed:26687600).  Required for the degradation of specific sqst-1-containing aggregates during embryogenesis and the early stages of larval development (PubMed:26687600).  Involved in allophagy, which is an autophagic process in which paternal mitochondria and organelles are degraded during fertilization, and moreover is required for the degradation of lgg-1-positive allophagic autophagosomes in embryos (PubMed:25126728, PubMed:24374177).  Involved in xenophagy, the autophagy-mediated degradation of pathogens and pathogen products, such as toxins (PubMed:27875098).  Also plays a role in membrane-pore repair (PubMed:27875098).  Through HOPS complex subunit vps-39, tethers lysosomes with autophagosomes to form autolysosomes (PubMed:24374177).  Plays a role in the distribution and clearance of germ cell specific P-granules from somatic cells to ensure exclusive localization of the P-granules in germ cells (PubMed:19167332).  Essential for dauer development and life-span extension (PubMed:20523114).
What are the official names of this protein?
Protein lgg-2.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome. Cytoplasm. Cell membrane; Lipid-anchor. Note=In embryos, diffuse cytoplasmic localization with some areas displaying a more punctate distribution (PubMed:24374177). Specifically, upon fertilization localizes to autophagosomes around the male pronucleus. During the first embryonic divisions and after the 25-cell stage, localizes to a small population of autophagosomes and to another small population of autophagosomes containing both lgg-1 and lgg-2. Localization to autophagosomes is dependent on atg-7.
Protein: COX2_NEUCR
Sequence: MGLLFNNLIMNFDAPSPWGIYFQDSATPQMEGLVELHDNIMYYLVVILFGVGWILLSIIRNYISTKSPISHKYLNHGTLIELIWTITPAVILILIAFPSFKLLYLMDEVSDPSMSVLAEGHQWYWSYQYPDFLDSNDEFIEFDSYIVPESDLEEGALRMLEVDNRVILPELTHVRFIITAGDVIHSFAVPSLGVKCDAYPGRLNQVSVFINREGVFYGQCSEICGILHSSMPIVIESVSLEKFLTWLEEQ
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II, Cytochrome c oxidase subunit Cox2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y1706_STRP2
Sequence: MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAIIGVNDHTLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGTSYYCNMASPYYLDEEALKYIDYDLDVKIFTDGEKRLLDVEEYERHKRKMNYSDDLDYILKEHVKILVDWINNGRGPFSEAYVNIWYKRYVELKNR
What are the official names of this protein?
UPF0374 protein SPD_1706.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: RECQ1_CAEEL
Sequence: MATFIFSRGNIFFYVNKITIPDLMSDVLLSKLSTELADLDGEIGQIDQQISQLRRKKSELTQKRQAIERKIELKTNEDSDVVTDRWDRDGFPWSDEATKILKEQFHLEKFRPLQRAAINAVMSKEDAVVILSTGGGKSLCYQLPALLANGLALVVSPLISLVEDQILQLRSLGIDSSSLNANTSKEEAKRVEDAITNKDSKFRLLYVTPEKLAKSKKMMNKLEKSLSVGFLKLIAIDEVHCCSQWGHDFRTDYSFLNVLKRQFKGVPILGLTATATSNVLDDVKDMLGIQAALTFRAGFNRSNLKYKVVQKPGSEDECTEEIAKTIKRDFAGQTGIIYCLSRNDCEKVAKALKSHGIKAKHYHAYMEPVDRSGAHQGWISGKIQVIVATVAFGMGIDKPNVRFVIHHSLPKSIENYYQESGRAGRDGQPATCILYYRLADIFKQSSMVQQERTGIQNLYNMVRYAADSSTCRRVKLAEHFEEAWEPSWCQKQCDTCENGNGFVGTSSKESTDVSEAAKTTVRIIEEHLNSAKDGSGRITGNKLVELLTKKLKGSRNREFCEKLIVNLLLEGYLQEDFHYTVYSVISYVVIGSKWRVYNGKDAIKMRHVEESKSRKRKASSSVEEEDVMVLD
What is the function of this protein?
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens.  Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity).
What are the official names of this protein?
Putative ATP-dependent DNA helicase Q1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLMU_AZOC5
Sequence: MSERSLLVVVLAAGEGTRMASRLPKVLHRIAGRSMLHHVLETTRQAGATRVAVVIGPDREDVAAEAHRVRPDAQVFVQTERLGTAHAVLAARAALEEPADDVLVLYADTPLLRPETLENLRAPLADGAAVAVLGFRPADPTGYGRLLTQGDALVAIREEKDATPDERRVDFCNAGVMALRAREALSILTRIGNANAKGEYYLTDAVEIARADGLSAVATEAEVDEVAGVNSRLQLAEAEAILQGRLRRAAMAGGATLVAPETVFLSVDTRLGRDVLVEPNVVFGPGVTVEDDVVIHAFSHLEGAHLERGVSIGPYARLRPGTRLGEGVRIGNFVETKAALIDAGAKVNHLSYVGDAHVGSNANVGAGTITCNYDGFSKHRTEIGAGAFIGTNSSLVAPVSVGAGAYIGSGSVITDDVPADALALGRGRQAVKEGWAAALRAARGKPKV
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPCC_ECOLX
Sequence: MKKVNHWINGKNVAGNDYFLTTNPATGEVLADVASGGEAEINQAVATAKEAFPKWANLPMKERARLMRRLGDLIDQNVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGITAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKKYSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKFAERANRVRVGDPTDPNTQVGALISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEALRLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQFVRDLRHAFGGVKPRTGREGGGYSSKCSRK
What is the function of this protein?
Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM).
What are the official names of this protein?
5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase, CHMS dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: HHT1_ARATH
Sequence: MVAENNKNKDVTLSASMDNNNNNIKGTNIHLEVHQKEPALVKPESETRKGLYFLSNLDQNIAVIVRTIYCFKSEERGNEEAVQVIKKALSQVLVHYYPLAGRLTISPEGKLTVDCTEEGVVFVEAEANCKMDEIGDITKPDPETLGKLVYDVVDAKNILEIPPVTAQVTKFKCGGFVLGLCMNHCMFDGIGAMEFVNSWGQVARGLPLTTPPFSDRTILNARNPPKIENLHQEFEEIEDKSNINSLYTKEPTLYRSFCFDPEKIKKLKLQATENSESLLGNSCTSFEALSAFVWRARTKSLKMLSDQKTKLLFAVDGRAKFEPQLPKGYFGNGIVLTNSICEAGELIEKPLSFAVGLVREAIKMVTDGYMRSAIDYFEVTRARPSLSSTLLITTWSRLGFHTTDFGWGEPILSGPVALPEKEVTLFLSHGEQRRSINVLLGLPATAMDVFQEQFLQI
What is the function of this protein?
Involved in the synthesis of aromatics of the suberin polymer.  Specifically affects the accumulation of the ferulate constituent of suberin in roots and seeds, but has no effect on the content of p-coumarate or sinapate.
What are the official names of this protein?
Omega-hydroxypalmitate O-feruloyl transferase, Omega-hydroxyacid hydroxycinnamoyltransferase, Protein ALIPHATIC SUBERIN FERULOYL TRANSFERASE.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: HIS4_CAMJD
Sequence: MTQIIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQLVLIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKFGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFYSNKGLKHILCTDISKDGTMQGVNVRLYKLIHEIFPKICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRCLQNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_RALPJ
Sequence: MHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLKDIQDFATPEGHGMLKVWMSHGDKVTELPPGFKLLASTPSCPVAGMADEARGYYAVQFHPEVTHTVQGRALLERFVLEIAGAKPDWVMRDHIDEAVKAIREQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHVDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPHEMVYRHPFPGPGLGVRILGEVKREYADLLRRADAIFIEELRGTKATAQDAAAGLCGEGDVGKSWYDLTSQAFAVFLPIKSVGVMGDGRTYDYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGLSRVVYDVSGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: CYC1_CLITE
Sequence: GIPCGESCVFIPCITGAIGCSCKSKVCYRNHVIAAEAKTMDDHHLLCQSHEDCITKGTGNFCAPFPDQDIKYGWCFRAESEGFMLKDHLKMSITN
What is the function of this protein?
Probably participates in a plant defense mechanism (Probable).  Active against Gram-negative bacteria E. coli ATCC 700926 (MIC=1. 1 uM), K. pneumoniae ATTC 13883 (MIC=2. 7 uM) and P. aeruginosa ATCC 39018 (MIC=4. 7 uM) (PubMed:21596752).  Has hemolytic and cytotoxic activity (PubMed:21596752).
What are the official names of this protein?
Cliotide T1.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: HEM6_PARMW
Sequence: MVRSLVRRLLGRSQNNGTAAPALELPPEDSRARARAMVMGLQDEICAGLESLDGEGTFVEESWERPEGGGGRSRVMREGLVFEQGGVNFSEVQGQELPPSILKQRPEAKGHPWFATGTSMVLHPHNPYIPTVHLNYRYFEAGPVWWFGGGADLTPYYPFLEDARHFHRTHQAACDSVHPDLHKVFKPWCDEYFFLKHRGETRGVGGIFYDYQDSSGVLYKGQDPSGPAAGVSAQLGARPLGWEQLFALGQANGRAFLPSYAPIVEKRHPMAYGDRERQFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLVRWEYGYKAEAGSREALLTELFTKPQDWLGDASLEDRCRPHGAIN
What is the function of this protein?
Involved in the heme and chlorophyll biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_PICTO
Sequence: MSRVPDNLYYTKSHEWFLIENGVATVGITDYAQHQLTDIVYVDFPKNGEHKNKGETLLTIESVKSAEDVYSPVTGEIIEINRDLESKPELINEDPYKNWLVKIRLSNDNFDGMSGEEYKKYIGE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Probable glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: PSAK_SPIOL
Sequence: GDFIGSSTNLIMVTSTTLMLFAGRFGLXP
What are the official names of this protein?
Photosystem I reaction center subunit psaK, chloroplastic, Light-harvesting 5 kDa protein, PSI-K, Photosystem I subunit X.
What is the protein family that this protein belongs to?
Belongs to the PsaG/PsaK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: HYEP2_CTEFE
Sequence: MSNCCRILWIAIVIGLGVLYYEITKEFPKPNIPLDTWWGTGKSQKIDTSMRPFKIAINDEVLNTLKVKLSDVSFTPPLEGIDFQYGFNTNTLKKLVDFWRTQYNWREREALLNKYPHFKTNIQGLDIHYVHIKPQVSKNIHVLPMIMVHGWPGSFVEFYKIIPMLTTPRTDYNFVFELILPSIPGYGFSQAAAKPGLGATQIAVIMHNLMDRIGFKKYYVQGGDWGSRIVSAMSTLFPENVLGHHSNLCFLNTLSSNIKSFVGSLFPEWFAGKQNVHKIYPLSEHFFTLLEESGYFHIQATKPDTVGVALRDSPAGLAAYILEKFSTGTNKAWRSAKDGNLQSKFTFTELLDNVMIYYVTGSITTSMRIYAESYSWDHLSLNMDRVPTIVPTACAKFPHEIAYKTDFQLAEKYKTLLQSTIMPRGGHFAALEEPLLLAEDIFSAVKKFIDHHSKKDSKNQENRDL
What is the function of this protein?
Catalyzes juvenile hormone hydrolysis.
What are the official names of this protein?
Juvenile hormone epoxide hydrolase 2, CfEH2, Juvenile hormone epoxide hydrolase II, JHEH II, Juvenile hormone-specific epoxide hydrolase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: HTPG_CUPMC
Sequence: MTAPHETMSFQAEVKQLLHLMIHSLYSNKEIFLRELVSNASDATDKLRFEAIANPALLENDADLAIRIEADPAARTLKITDNGIGMSRDEAIRNLGTIARSGTKEFFQQLSGDQQKDAALIGQFGVGFYSAFIVADKVTVETRRAGLAADEAVRWESAGDGEFSIDAINRAERGSTITLHLREGEDDFLSSYRLQNIIRKYSDHISLPIRMPKEEWDAEAQQQKVTGEWESVNQASALWTRSKSDITDEQYQAFYQHIAHDHEAPLAWTHNRVEGRSEYTQLLYIPARAPFDLWDRNHKAGLKLYVKRVFIMDDADQLLPAYLRWVKGVVDSADLPLNVSRELLQESRDVKAIREGCAKRVLSMLEAMADSEDEAERAKYKTFWEQFGQVLKEGVGEDHGNGERIAKLLRFATTHGDTAEQSVSLVDYVGRMKEGQDKIYYVTADTWVAAKSSPHLEVFRKKGIEVVLLTDRVDEWLLSYLHEFDGKQLVSVARGDLDLGALADEAEKAEQEKASADWKEVVDRAKSVLEGKAKDVRVTLRLTDSASCLVSDDGDMSGYLQRLLKQAGQKAPDAQPILELNPEHALVKKLRDLPDGEAFGDRVRVLFDQALLAEGGMLDDPAAYVQRVNRLLA
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAS9A_STRTD
Sequence: MSDLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTNRQGRRLARRKKHRRVRLNRLFEESGLITDFTKISINLNPYQLRVKGLTDELSNEELFIALKNMVKHRGISYLDDASDDGNSSVGDYAQIVKENSKQLETKTPGQIQLERYQTYGQLRGDFTVEKDGKKHRLINVFPTSAYRSEALRILQTQQEFNPQITDEFINRYLEILTGKRKYYHGPGNEKSRTDYGRYRTSGETLDNIFGILIGKCTFYPDEFRAAKASYTAQEFNLLNDLNNLTVPTETKKLSKEQKNQIINYVKNEKAMGPAKLFKYIAKLLSCDVADIKGYRIDKSGKAEIHTFEAYRKMKTLETLDIEQMDRETLDKLAYVLTLNTEREGIQEALEHEFADGSFSQKQVDELVQFRKANSSIFGKGWHNFSVKLMMELIPELYETSEEQMTILTRLGKQKTTSSSNKTKYIDEKLLTEEIYNPVVAKSVRQAIKIVNAAIKEYGDFDNIVIEMARETNEDDEKKAIQKIQKANKDEKDAAMLKAANQYNGKAELPHSVFHGHKQLATKIRLWHQQGERCLYTGKTISIHDLINNSNQFEVDHILPLSITFDDSLANKVLVYATANQEKGQRTPYQALDSMDDAWSFRELKAFVRESKTLSNKKKEYLLTEEDISKFDVRKKFIERNLVDTRYASRVVLNALQEHFRAHKIDTKVSVVRGQFTSQLRRHWGIEKTRDTYHHHAVDALIIAASSQLNLWKKQKNTLVSYSEDQLLDIETGELISDDEYKESVFKAPYQHFVDTLKSKEFEDSILFSYQVDSKFNRKISDATIYATRQAKVGKDKADETYVLGKIKDIYTQDGYDAFMKIYKKDKSKFLMYRHDPQTFEKVIEPILENYPNKQINEKGKEVPCNPFLKYKEEHGYIRKYSKKGNGPEIKSLKYYDSKLGNHIDITPKDSNNKVVLQSVSPWRADVYFNKTTGKYEILGLKYADLQFEKGTGTYKISQEKYNDIKKKEGVDSDSEFKFTLYKNDLLLVKDTETKEQQLFRFLSRTMPKQKHYVELKPYDKQKFEGGEALIKVLGNVANSGQCKKGLGKSNISIYKVRTDVLGNQHIIKNEGDKPKLDF
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein.  The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA.  Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA).  Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs.  PAM recognition is also required for catalytic activity (By similarity).  Cuts target DNA when Cas9 and gRNAs are mixed.
What are the official names of this protein?
CRISPR-associated endonuclease Cas9 1, Cas9**.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas9 family. Subtype II-A subfamily.
Protein: DACB_ECOLI
Sequence: MRFSRFIIGLTSCIAFSVQAANVDEYITQLPAGANLALMVQKVGASAPAIDYHSQQMALPASTQKVITALAALIQLGPDFRFTTTLETKGNVENGVLKGDLVARFGADPTLKRQDIRNMVATLKKSGVNQIDGNVLIDTSIFASHDKAPGWPWNDMTQCFSAPPAAAIVDRNCFSVSLYSAPKPGDMAFIRVASYYPVTMFSQVRTLPRGSAEAQYCELDVVPGDLNRFTLTGCLPQRSEPLPLAFAVQDGASYAGAILKDELKQAGITWSGTLLRQTQVNEPGTVVASKQSAPLHDLLKIMLKKSDNMIADTVFRMIGHARFNVPGTWRAGSDAVRQILRQQAGVDIGNTIIADGSGLSRHNLIAPATMMQVLQYIAQHDNELNFISMLPLAGYDGSLQYRAGLHQAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQYLSGYAVEPADQRNRRIPLVRFESRLYKDIYQNN
What is the function of this protein?
Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.
What are the official names of this protein?
D-alanyl-D-alanine carboxypeptidase DacB, DD-carboxypeptidase, DD-peptidase, D-alanyl-D-alanine endopeptidase, DD-endopeptidase, Penicillin-binding protein 4, PBP-4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S13 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: INH3_ARATH
Sequence: MSTATRPSSSATTSVILENPVSQSQPTERLVLRLNRKKKKVSWKDGTVDNEFMQKKSSKKCCIFHKQKPFDEDDSEEEDDNNHHCDHNHEHSESGEASSSNDSKAVD
What is the function of this protein?
Inhibitor of protein-phosphatase 1 (PP1).  Binds to and inhibits PP1 activity.  Required for early embryogenesis progression.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit INH3, Protein INHIBITOR-3, AtINH3.
Protein: RBFA_CHLTR
Sequence: MAENRRMKKVNAMLREAIAKVILKDVKHPKISNRWITITRVSLSRDLQSACVYVSIMPHENSQEETLAALKASAGFIAFQASKDLVLKYFPDLNFYVEDIFSPQDHIESLLLKIAEQDKKTNP
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSK22_HUMAN
Sequence: MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
What is the function of this protein?
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.  Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection.  May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response.  During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage.  Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation.  Can also negatively regulate apoptosis.  Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3.  Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8.  Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV.  Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB.  Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function.  Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1.  Acts as an ectokinase that phosphorylates several extracellular proteins.  During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
What are the official names of this protein?
Casein kinase II subunit alpha', CK II alpha'.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Interaction with SIRT6 prevents translocation into the nucleus.
Protein: HMGX7_CHICK
Sequence: MAPAADMTTAPTGVRSDEPPASAFSKPGGGLPVAAAMGGEEESDKPKVSPSPLPFSVEALMADRRKPPGGRDGPEGSGPPLGSARANLGALTTEAPTSPLPLGGHFPSVGALGKLPEDALLKAESPEKPERSPWMQSPRFSPPPPRRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGISFPLGGPAVAGASLYGASSPFQRAGLPVAPVGLYTAHVGYSMYHLT
What is the function of this protein?
Probably plays a role in patterning events during embryonic limb development.  May also be involved in programmed cell death.
What are the official names of this protein?
Homeobox protein GHOX-7, CHOX-7, Hox-7.
What is the protein family that this protein belongs to?
Belongs to the Msh homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTH_CITK8
Sequence: MTIKLIVGLANPGAEYAATRHNAGAWYVDLLAERLRAPLREEPKFFGYTSRVTLEGEDVRLLVPTTFMNLSGKAVGAMASFYRIMPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIINKLGNNPNFHRLRVGIGHPGDKNKVVGFVLGKPPVSEQKLIDDAIDEAARCTEVWFKEGLTKATNRLHAFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.