PharMolix/UniProtQA huggingface dataset:
Protein: ACCA_HELPY
Sequence: MAVYLDFENHIKEIQNEIELALIRGDEDAKEILEKRLDKEVKSIYSNLTDFQKLQLARHPDRPYAMDYIDLILKDKYEVFGDRHYNDDKAIVCFVGKIDNVPVVVIGEEKGRGTKNKLLRNFGMPNPCGYRKALKMAKFAEKFNLPILMLVDTAGAYPGIGAEERGQSEAIAKNLQEFASLKVPTISVIIGEGGSGGALAIAVADKLAMMEYSIFSVISPEGCAAILWDDPSKTEVAIKAMKITPRDLKEAGLIDDIILEPSKGAHRDKFSAANTIKEYFLDALRTIQQDPHFLDNRYQKLMSLGSFVESMN
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG089_VACCC
Sequence: MGIKNLKSLLLENKSLTILDDNLYKVYNGIFVDTMSIYIAVANCVRNLEELTTVFIKYVNGWVKKGGHVTLFIDRGSIKIKQDVRDKRRKYSKLTKDRKMLELEKCTSEIQNVTGFMEEEIKAEMQLKIDKLTFQIYLSDSDNIKISLNEILTHFNNNENVTLFYCDERDAEFVMCLEAKTHFSTTGEWPLIISTDQDTMLFASTDNHPKMIKNLTQLFKFVPSAEDNYLAKLTALVNGCDFFPGLYGASITPNNLNKIQLFSDFTIDNIVTSLAIKNYYRKTNSTVDVRNIVTFINDYANLDDVYSYVPPCQCTVQEFIFSALDEKWNNFKSSYLETVPLPCQLMYALEPRKEIDVSEVKTLSSYIDFENTKSDIDVIKSISSIFGYSNENCNTIVFGIYKDNLLLSINNSFYFNDSLLITNTKSDNIINIGY
What is the function of this protein?
Putative nuclease that seems to be required for double-strand break repair, homologous recombination, and production of full-length viral genomic DNA.
What are the official names of this protein?
Putative nuclease OPG089, Putative nuclease G5.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: QUEC_NEIMB
Sequence: MSNQQALVIFSGGQDSTTCLIQAIQTYGRENVQAITFQYGQRHAVELERARWIAQDLGVKQTVLDLSLMRQITHNALMDDTAAIETAENGVPNTFVDGRNALFLLYAAIYAKGQGIRHIIAGVCETDFSGYPDCRDVFVKSMNVTLNLAMDYDFQIHTPLMYLTKAQTWALADEMGVLDYIREQTHTCYNGIVGGCRECPSCILRERGLAEYLESKKAV
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: TLCB_RICFE
Sequence: MDAVDSNFTIWNKARNSKFRHIVWPIRSYELTKFIPMVLLMFFILLNQNLVRSIKDSFVVTLISSEVLSFIKLWGEMPMGILFVILYSKLCNIMTTEQVFRIITGTFLFFFAIFGFILFPYREFFHPDPELIKHYITVLPHLKWFLIIWGQWSLVLFYIMGELWPVIVFTLLYWQLANKITKVEEAPRFYSFFTLFGQTNLLISGTVIIYFAKSEHFLLPLFSHLNDTNEILLKSFITVILISGLICLALHKLIDKSVVEADKNIKFKNQRTDILKLSLVESAKVILTSRYLGFICLLVMSYSMSISLIEGLWMSKVKQLYPATKDFISYHGEVFFWTGVLTLVSAFLGSSLIRICGWFWGAIITPIMMFGAGVMFFSFTVFENHLENIVNTLGYSLPLVVIVFIGGLWHVLSKSVKYSLFDATKEMVYIPLDSEMKTKGKAAVDVMGTKIGKSIGAIIQFISFSIFPNAVHNDIAGLLMFSFVIVCLLWLYGVKVLSEQYNKMIKR
What is the function of this protein?
Provides the rickettsial cell with host ATP in exchange for rickettsial ADP.  This is an obligate exchange system.  This energy acquiring activity is an important component of rickettsial parasitism (By similarity).
What are the official names of this protein?
ADP,ATP carrier protein 2, ADP/ATP translocase 2.
What is the protein family that this protein belongs to?
Belongs to the ADP/ATP translocase tlc family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS8_RHIEC
Sequence: MTMTDPLGDMLTRIRNGASRRKSSVSTPASKLRARVLDVLQSEGYIRGYSVVDFGNGKSELNIELKYYEGASVIREIGRVSKPGRRVYVSVKSIPQVANGLGITILSTPKGVMADHQAREQNVGGEVLCSVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: HSLV_PARXL
Sequence: MEQFHGTTIVSVRRGDKVALGGDGQVTLGNIVMKGGAKKVRRIYNGKVMVGFAGGTADAFSLLDRFEAKLEKHQGNLTRAAVELAKDWRTDRMLRRLEAMLIAADATTTLVITGNGDVLDPEGGICAIGSGGAYAQAAAKALADNTELSPREIVEKSLEIAGDMCIYTNHNRVIETIE
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_MYCSJ
Sequence: MTAATEQKEKTGTDNVGRVVRVTGPVVDVEFPRGSVPELFNALHAEISYKDLAKTLTLEVAQHLGDSLVRCISMQPTDGLVRGVDVTDTGASISVPVGEGVKGHVFNALGACLDDPGYGKDFEKWSIHRKPPAFDELEPRTEMLETGLKVVDLLTPYVRGGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELADANVLKDTALVFGQMDEPPGTRMRVALSALTMAEYFRDEKQQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDATTELSRSVFSKGIFPAVDPLASSSTILDPSVVGDEHYRVAQEVIRILQRYKDLQDIIAILGIDELAEEDKQLVQRARRIERFLSQNMMAAEQFTGQPGSTVPLKETIEAFDKLSKGDFDHLPEQAFFLIGGLEDLQRKAESMGAKMDDGGSDGAPPPSDSKDKGKGDSKADDKGDDADKDA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: AROK_BUCBP
Sequence: MTEKRNIFLIGPMGAGKSTIGRHLAQQLSMEFYDSDQEIEKRTGVDVSWIFDIEGELGFRKREQKIISEIIDKRGIVLSTGGGSILSREIRNKLSSRGVVIYLETSVEKQLVRTKKNKQRPLLQVDNTSIQTVLEELAFHRNPLYQSIADITIRMNDRSIKAIVFYIIRLLNNF
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATE_THEGJ
Sequence: MTEKFDYKELGLKVGLEIHRQLDTKKLFSPVPSELTEKVDFTFERRLRPTMSELGEIDPAALEEFKKGRKYIYEGNYELSDLVYMDEEPPRGPDREALEVTLQIAYLLNAKPVDEVHFMRKIVIDGSNVSGFQRTAIIALDGKVDTPWGSVGIPTICLEEDACRIVERKEKEVIYRLDRLGIPLVEISTTPDIHHPEQAKVVAKYIGDALRATRKVKRGLGTIRQDLNVSIKGGARVEIKGVQELDMIPLIIEREVERQLNLLKIRDELRERGVRPEDIKEEFYDVTDVFENTESKIIARTIKKGGNVLAVKLPKFRGLIGREIQPGRRLGTEMADRAKKYVKGIFHIDELPNYGITEKEVNAVIEKLGLGELDAFVLVAADEETAKKALREVIKRAREAIEGVPEETRRALPDGNTQYMRPLPGKARMYPETDIPSIFIPPEEKERIKANLPELPQERVERYVKEYRIDKSLAETLVNDERDELFEELVKKGVKPSLAASILVVVLKGLKKEVPIENITDDHIREAFQLYTEGKIAKEAFEEIFKELALHPEKSAAQVAEEKGLTLLSEEEVERIIDEVVQQNIEVIKAKGMGAMGMIMGRAMAKLRGRADGKLVSTLVRRKIQELS
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit E, Glu-ADT subunit E.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatE subfamily.
Protein: YVDH_VACCW
Sequence: MTFINNDAYSTLGINSFDISKKFISKILIIVINKNTILRYLWSVSEYSVHPRIFYQSLFHQ
What are the official names of this protein?
Uncharacterized 7.2 kDa protein.
Protein: LFTR_CUPPJ
Sequence: MIAWLDPHDPFPPVERALGPATEAPGLLAASRDLSPQRLLLAYRQGIFPWYSVGQPVLWWSTDPRMVLAPQALKISATFRKTLRRVLRDPDWEIRVDDDFLAVMRACAMTPREGQDGTWITREIIAAYGALHSNGMAHSVETWYRGTRVGGLYGVALGRMFYGESMFAHRTDASKIALAALCAFLGSHGVPMIDCQQETDHLASLGARPIARAEFLAHVRNASAQPAITPWWFDKSVLERWTATPATPAV
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACC_STRPN
Sequence: MILTVTMNPSIDISYPLDELKIDTVNRVVDVTKTAGGKGLNVTRVLSEFGDSVLATGLVGGKLGEFLVEHIDNQVKKDFFSIKGETRNCIAILHGDNQTEVLEKGPEVLEQEGQEFLEHFKKLLESVEVVAISGSLPAGLPVDYYASLVELANQAGKHVVLDCSGAALQAVLESPHKPTVIKPNNEELSQLLGREVSEDLDELKEVLQEPLFAGIEWIIVSLGANGTFAKHGDTFYKVDIPRIQVVNPVGSGDSTVAGISSGLLHKESDAELLIKANVLGMLNAQEKMTGHVNMANYQALYDQLIVKEV
What are the official names of this protein?
Tagatose-6-phosphate kinase, Phosphotagatokinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
Protein: Y217_HELPJ
Sequence: MKKPYRKISDYAIVGGLSALVMVSIVGCKSNADDKPKEQSSLSQSVQKGAFVILEEQKDKSYKVVEEYPSSRTHIVVRDLQGNERVLSNEEIQKLIKEEEAKIDNGTSKLVQPNNGGSNEGSGFGLGSAILGSAAGAILGSYIGNKLFNNPNYQQNAQRTYKSPQAYQRSQNSFSKSAPSASSMGTASKGQSGFFGSSRPTSSPAISSGTRGFNA
What are the official names of this protein?
UPF0323 lipoprotein jhp_0217.
What is the protein family that this protein belongs to?
Belongs to the UPF0323 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: MURG_NITWN
Sequence: MTTAPLILLAAGGTGGHLFPAEALGVELMKRGLRVRLVTDSRALRYSGLFSKDLTDVVPSETVRGRSPWALARTGLMLAAGTAVALNLMRVLKPAAVVGFGGYPTLPPLIAARLRGIPTVIHDSNAVMGRANSFLSKRVNAIATSLPGVLDKKPSLAGKITTTGTPMRPAILAAAAVPFATPGLGDPLRVLVVGGSQGARVMSDIVPGAIERLEPALRQRLILTQQVRDEDMARVRGFYDRLEIKAELAPFFADLPARLASNHIIISRSGAGTVAELGAIGRPSILVPLPGAIDQDQFANAGVLADVGGAIRIVQPDFTPDRLAAELSALAAGPARLAAMATAARTVGRLDAAGRLADLVMRVARTGA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL13_RICRO
Sequence: MKTYSAKPSEIEKKWWVIDAKNIVLGRLASRVANMLRGKHKPSFTPHLDCGDNIIIINAEHVNLTGKKANPKDGKIYYRYTGFPGGIKDTTAGKILSGKHPERVIKMAVKRMITRNALGAKQMSNLYVYANGDHPHMAQQPTVYDFASQNPKNKK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: SYK_HISS2
Sequence: MTEIIQELDLNGEMLVRREKLAALRAKGNAFPNTFRRNALAQDLHTQYDEIESESLKTQGIEVKVAGRIMTRRVMGKATFITLQDMSGKIQLYVARDNLAEGVYTDDVGNWDLGDIVGVKGTLFKTKTNELTIRATEVHLLTKALRPLPNKFHGLSDQETRYRQRYLDLIANEDSRRTFIIRSKVIAGIREYFISKGFMEVETPMLQIIPGGASARPFITHHNALDVDMYLRIAPELYLKRLVVGGFERVFELNRNFRNEGVSIRHNPEFTMLEYYQAYADYHDLMDNTEELLRKLALDILGTTIVPYGDLKFDFGKPFERITMHEAILKYGAEQGIVKEDLYDFDRAVAVAQKLGIEVQKSWGLGSLVNAIFEEVAEHHLIQPTFLMAHPAEISPLARRNDENPDVTDRFELFIGGREIGNGFSELNDAEDQNERFDAQVAAKEAGDDEAMFKDEDFVTALEHGLPPTAGEGLGIDRLAMLFANANSIRDVILFPAMKTKS
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN1_COPC7
Sequence: MGIKGLTGLLNEHAPNSIKEHDIKTLFGRKVAIDASMSIYQFLIAVRQRDGEMLTNDAGETTSHLMGFFYRTIRIVENGIKPAYVFDGKPPELKKGVLSKRFEKREEAKEEGEEAKEIGTAEDVDRFSRRTVKVTKQHNEECQKLLRLMGVPCVIAPSEAEAQCAELARGGKVYAAGSEDMDTLTFNAPILFRHLTFSEAKKQPISEINLEAALKGLDMDMSQFVDLCILLGCDYLEPIKGVGPKSALKLIREFGGLKEVVEHLREKAAARKAEAEEEDEEEAEEPAPTSDVEMPDDEDGEKDSDDEEEAERRKKAEAAKKKKAQEKAKSAKKGKGKGKGGIQIPDEWPWEEAKQIFLKPDVIPADQVELEWKNPDVEGLVQFLVTEKGFSEERVRKGAEKLTKFLNAKQQGRLDGFFTVKPKQAPPPAAKGKGAASKGTKRKGEDKAEGSGKKAKKK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: NADD_XYLFA
Sequence: MPSLHVFYGGTFDPVHVGHLAIARAAHAALQAPIALIPSADPPHRPTPGSSSMDRLRMLQLAVSKEPGLSADPRELQRAARQNRSSYTVDTLTEVRSELGPKTSIIWLLGADAFVNLSNWKDWQMLPALTHLVIANRPGITLQTQLPPKMATVFNHRWVQDPATLRNTPHGHLWLLNQPPNPSSASKVRAAISAAAHWEADLTPEVAQYIRTHRLYGIHDIN
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: CASA2_EQUAS
Sequence: MKFFIFTCLLAVALAKHNMEHRSSSEDSVNISQEKFKQEKYVVIPTSKESICSTSCEEATRNINEMESAKFPTEVYSSSSSSEESAKFPTEREEKEVEEKHHLKQLNKINQFYEKLNFLQYLQALRQPRIVLTPWDQTKTGASPFIPIVNTEQLFTSEEIPKKTVDMESTEVVTEKTELTEEEKNYLKLLNKINQYYEKFTLPQYFKIVHQHQTTMDPQSHSKTNSYQIIPVLRYF
What is the function of this protein?
Important role in the capacity of milk to transport calcium phosphate.
What are the official names of this protein?
Alpha-S2-casein.
What is the protein family that this protein belongs to?
Belongs to the alpha-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: DPASB_ARTSH
Sequence: MDVHDLTRAPPEYLEVVWVTDVCKLVMAVGWLSNYIGMIAKSIKEQTYSMALMPLCCNFAWEFTYFFIYPYKVPMERNIHTLAFLLNCGVMYTAVRYGAREWGHAPLVQRNLPVIFVVCIACWVSAHVAFAEQYGPSLAQAVSGFACQILLSAGGTCQLLCRGHSRGASYKLWLARFMGSFALILPNMLRYKYWRDDHQYIGSPLYIWFLGMFLFLDGSYGFVLWYVRRHEREQVLVAKPKVQ
What is the function of this protein?
Terpene cyclase; part of the gene cluster that mediates the biosynthesis of the diterpenoid pyrones subglutinols A and B (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpasA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (PubMed:32286350).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpasD through the action of the prenyltransferase dpasC to yield a linear alpha-pyrone diterpenoid (PubMed:32286350).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpasE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpasB (PubMed:32286350).  The FAD-linked oxidoreductase dpasF is then involved in tetrahydrofuran (THF) ring formation at the C5 unit to complete the formation of subglutinols A and B (PubMed:32286350).  DpasF possesses also an additional catalytic ability of multi-step oxidations to generate a new DDP analog with an enone system at the C5 named FDDP A (PubMed:32286350).
What are the official names of this protein?
Terpene cyclase dpasB, Diterpenoid pyrone biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the paxB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y4090_STRMK
Sequence: MPSFDVVSEVDTHELTNAIDQANRELATRFDFKGVDAKFERDGDVINQFAPTEFQLKQMNDILRARLAARGIDVLSLEFGDIETNLAQARQKITVKQGIEQKIAKKIAAALKDAKLKVESQINGDKLRVQGKKRDDLQDAIAVLKAGKFELPLQFNNFRD
What are the official names of this protein?
UPF0234 protein Smlt4090.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: RPIA_ERWT9
Sequence: MTQDELKKAVGWAALDYVTPGTIVGVGTGSTAAHFIDALASIKHQIEGTVSSSEMSTARLKAYGIPVFDLNEIDALSLYVDGADEINGQMQMIKGGGAALTREKIIAAVADRFICIADESKQVDVLGHFPLPVEVIPMARSYVARELVKLGGLPEYRQDVITDNGNIILDVYNLSIIDPIRLETAINALTGVVTVGLFAARGADVALIGTADGVKTIKK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: RCD12_NEUCS
Sequence: MDNEEWFPLKQTHYPPPTIPSMKTGHPTGPISIGHIIPDLRHLDNVINCKGFEPFPPNMDVFTAHYEQCHFGDHLNSEFVVQAKAAAPIKNIVPGVDVTGSAGLHHTNITSDRWEYDSVVEYAVYPTRQYIDRLLESKEVKQYIQKSKKLLGGWCVYMVTGIMVARGGGRNVVSEEKGAGVFGNVGFQVPGIGEXAPEVGWDTKTKTKVNAHHTTDFVCAIRLVKIAKSGLRSSWTMKKVTREF
What is the function of this protein?
Gasdermin-like protein involved in heterokaryon incompatibility, a process that ensures that during spontaneous vegetative cell fusion, only compatible cells from the same colony survive (non-self-recognition) (PubMed:31636083, PubMed:32703806).  In N. crassa, the rcd-1 locus exists as 2 incompatible alleles, rcd-1-1 (AC Q7SBA0) and rcd-1-2 (this entry) (PubMed:31636083).  During the allorecognition process, forms a heterooligomer with rcd-1-1, thereby forming a functional gasdermin-like complex that binds to membranes and forms pores, triggering cell death (PubMed:32703806).  Binds negatively charged phospholipids, such as cardiolipin and phosphatidylserine (PubMed:32703806).  Also binds to phosphoinositides, preferentially to phosphatidylinositol-3-phosphate (PtdIns-3-P), PtdIns-5-P and PtdIns-3,5-P2 (PubMed:32703806).
What are the official names of this protein?
Gasdermin-like protein rcd-1-2, Regulator of cell death 1-2.
What is the protein family that this protein belongs to?
Belongs to the gasdermin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Multi-pass membrane protein. Note=Cytoplasmic in the absence of rcd- 1-1 (PubMed:32703806). Forms a gasdermin-like pore that associates with the cell membrane in the presence of rcd-1-1 (PubMed:32703806).
Protein: TRMB_BACMK
Sequence: MRLRHKPYAMDRINEYSHIVIGNPEESAGNWKEIFGNEQPIHIEVGTGRGRFMYDMAKANPHINYIGIEKFTSVVVDALDKLIEEEVPNLKLINKDAEDLTVFFAKGEIDRVYLNFSDPWPKNRHTKRRLTYKTFLRNYEEVLVDGGEIHFKTDNQGLFEYSIMSMAEYGMLLTYLSLDLHNSDYEGNIMTEYEEKFSSKGHRIYRVEAKYRTEPMQ
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: ATG9_EMENI
Sequence: MMASNVLSRLLPQTGQSVYETIRQHDNDSDASDVEERAGLVYDDDVNLGNRFSDRELEEAMADATREGSSSPSDTFLTPQIAQRGERSASSGPRMRKPNNPRFMRSVTPRPEFVEDDLDDDHDDDVPASLLMEGQHDDEYLRTRLPPPPSHHFSDPQPSRSARSPRREHIRTFAFVVGFTTFLTNCIDYRLVRTSKSLDQILISKCTSRMSASSTFLLWLLCLFWIGKIFQLILDIRRLKNMHDFYHYLLGVSDAEIQTISWQEVVSRLMTLRDANPATAGAVSAFNRRLLGSQSKQRMDAHDIANRLMRKENYLIALINKDILDLTLPIPFLRNRQLFSRILEWNINLCIMDYVFNEQGQLSSRQYTPLAEWKFREFNELWHLFEKRINLSYPYATRYVDQFPKDKTVQVAGFVAFISGALASVLALASILDPELFLGFELTHDRTTLFYLGVFGSVWAFARGMVPEETLVFDPEYALLEVIQFTHYFPSHWKGKLHSDDVRREFAVLYQMKIIIFMEEILSMIFTPFILWFSLPKCSERVIDFFREFTVHVDGMGYLCSFAVFDFKKGTNVIPQGHINQRDARQDPRVDYFSTKDGKMLASYYGFLDNYGGNPRATNANKRAFHPPPTFPSLGSPPFVGASNIGNRQDPIQARVNTASAALGQQSMLGATRLGALGVGDTQSPAPSLLLDPQHQPSASGFRATNHIAPHHRQRLGRPPPAPVSESIIDDNEPSIAAARRPAPRRKSGQLHTNSGSSEALGAGDSNVEDSWGMKSGGEVNDEDAEENVDDVVGGAGVLGLIQQFQKVNKDNRPRAAVGL
What is the function of this protein?
Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation.  Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome.  Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through atg2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.  Required for mitophagy.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.
What are the official names of this protein?
Autophagy-related protein 9.
What is the protein family that this protein belongs to?
Belongs to the ATG9 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GPA4_CAEEL
Sequence: MGCFHSTGSEAKKRSKLIDEQLRHDHERCVGEIKLLLLGAGESGKSTIVRQMRILHETGFNKQEQMAYRPVVFSNMVQSMLAILKAMQPLNISFTDAAREEDARMFISHFLHVNNAELSEAFSLELSDLMKQLWMDEGVKKCVKRAHEYQLNDSAEYYFNALDRISSSSYLPTQDDILRARVKSTGIVETTFMYKDLCFKMFDVGGQRSERKKWIHCFDSVTAVIFCVALSEYDLRLAEDQTMNRMHESMQLFDSIVNNCWFTETSIILFLNKMDIFEERIRYTPLTVCFPEYQGGMTITETSTFIQSRFEILNKRQTPAQKEIYSHFTCATDTNNIRFVFDAVTDIIIRNNLYLCGLY
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-4 subunit.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Protein: EPO_DANRE
Sequence: MFHGSGLFALLLMVLEWTRPGLSSPLRPICDLRVLDHFIKEAWDAEAAMRTCKDDCSIATNVTVPLTRVDFEVWEAMNIEEQAQEVQSGLHMLNEAIGSLQISNQTEVLQSHIDASIRNIASIRQVLRSLSIPEYVPPTSSGEDKETQKISSISELFQVHVNFLRGKARLLLANAPVCRQGVS
What is the function of this protein?
Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
What are the official names of this protein?
Erythropoietin, Erythropoietin-L2.
What is the protein family that this protein belongs to?
Belongs to the EPO/TPO family.
What are the subcellular locations of this protein?
Secreted.