PharMolix/UniProtQA huggingface dataset:
Protein: AROC_BUCCC
Sequence: MPGNSIGKIFKVTTCGESHGPMLAGIIDGVPPGLSLNNKDIQYELNRRRPGFSKFTSQRREKDKVEIFSGIFKGITTGTSIGIRIKNIDIRSQDYSEIKNLYRPNHADYTYEKKYGIRDYRGGGRSSARETAIRVAAGAIAKKYLKLQHNIKIRGYLSQIGSIYCPFQSWEEVEKNPFFCSNSEKIKKIIHFIKKLKKSGNSVGAKITIIAKNVPIGLGEPVFDRLNAEIAHSIMSINAAKSIEIGDGIHVAKQTGVEHRDEILPNGFSSNHSGGILGGISNGEEIIVHAAFKPTSSIKIPGKTIDTFGKKRFIITKGRHDPCVGIRAVPIAEAMLAITLMDHVLRFKAQCGK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: FIG4_YEAST
Sequence: MNNDAMEHTLGGGILTTSGSKQRKTSKFVMGKYTLYETKDRMYIVGSNKRETMFRILEIDLTVPRGELTVLEDNVFFTRNEIMNVLASLEEATEDGLHKKITGYGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILREKLKAVDRCDITIPCGITDYNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDRYTSFVQHRGSIPLYWTQDASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGGGTIQILNLIKTKEKTPRETKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTVTTTGIFHNGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFPSLWEMNTDFYLHNAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGNDVTREKIIKNVRGYPGAFDNYWNEYYLPRSVTWIRDLFAYNMNSTRRYHNALSKQDKAMSPFTSRKQSWLNNKLKMITSSKSLEKAEGRVVETTDLDRDTSPKQELELYEHYLHIISDRSQKLEEKMNSFSYSKYPIFISHESSEIPPMRKVIGEPLVDIAEDFTDVYDDDDDGDDENDEMTTEALLIAPDHVSVDEKFYEKVLNVDDYKPALDDYSAVIHIKPDNLQLYRDLCFSKDIQLDFQ
What is the function of this protein?
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Major enzyme required for hyperosmotic shock-induced turnover of PtdIns(3,5)P2 and requires VAC14 for this function.  In vivo, mediates turnover of PtdIns(3,5)P2 at the vacuole membrane necessary for vacuolar size control.  In vitro, catalyzes the removal of phosphate from the fifth hydroxyl of the myo-inositol ring of phosphatidylinositol 3,5-bisphosphate.
What are the official names of this protein?
Polyphosphoinositide phosphatase, Factor-induced gene 4 protein, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein. Note=Localized to the limiting membrane of the vacuole. Localization requires VAC14 and FAB1.
Protein: CLD14_HUMAN
Sequence: MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGYRLNDYV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
What are the official names of this protein?
Claudin-14.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: OBG_BACAN
Sequence: MFIDQVKIYVKGGDGGNGMVAYRREKYVPKGGPAGGDGGKGADVVFIVEEGLRTLMDFRYQRHFKADRGQHGMSKGQHGRKSEDLLVKVPPGTVVKDEKTGQILADLVTHGQTAVIAKGGRGGRGNSRFATATNPAPEIAENGEPGQERDVILELKVLADVGLVGFPSVGKSTLLSVVSSARPKIAEYHFTTIVPNLGVVETGDNRSFVMADLPGLIEGAHAGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYEDYVTINNELKEYNLRLTERPQVVVANKMDMPDAEENLQAFKEKVGDEVKIFPISAVTKQGVRDLLFEVANLIETTPEFPIHEVVDESDTSVMYKFETEGVKFDITRESDGTFVISGYDIEKTFKMTDFSRDESVRRFARQMRGMGIDEALRARGAKDGDIVKILEYEFEFID
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2691_EDWI9
Sequence: MEMTNAQRLLLSNQYKMMSMLDPENAERYRRLQTIIERGFGLQLRELDRDFGELPEETCRSIIDIMEMHHALQVSYNNLKDRQDIDARRLEFLGFDAATEARYLSYVRFLVNTEGRYTHFDCGSHGFNAQTKMWDKYLRMLAVWHACPRQYHLSAVEIMQILNA
What are the official names of this protein?
UPF0304 protein NT01EI_2691.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: CCMD_PSEFL
Sequence: MSFASFSDFLAMAHHGLYVWTAYAICLAVLVLNVAAPILARKRYLQQEARRLRRETEK
What is the function of this protein?
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
What are the official names of this protein?
Heme exporter protein D, Cytochrome c-type biogenesis protein CcmD.
What is the protein family that this protein belongs to?
Belongs to the CcmD/CycX/HelD family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NU2C_PARMW
Sequence: MPEMGVFLLAAQAMAAPGELLNLSLNATAVLPEGAVLLAMIATLLVDLAGEKVAARWVPPICYGGLGTALVLLALQWNAPVESSFLGAFLADNLAVAFRAVIALSTLLSLLISWRYAEQSGTPVGEFAAILLAATLGAMLLCGATDLVSVFISLETLSVASYLLSGYMKRDARSSEAALKYLLVGSAAAAVFLYGSSLLYGLSGSTSLEAIGVALQTSTTPVAALSLVFVLATVAFKIAAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAGFALALRILVGCFGAFDGQWKLLFTVLAVLSMTLGNVVALAQTSMKRMLAYSSIGQAGFVMIGMVCGTEDGFAAMVLYMAAYLFMNLGAFACIILFSIRTGSDRISDYAGLYQKDPLITLGLSLCLLSLGGIPPMLGFFGKIYLFFAGWADHQYLLVVVGLITSVVSIYYYISVIKMMVVKEPQEASDIVKAYPDVSWSVMGMQPLRVALIGCVAVTAVGGILSNPLFQWANTAVTSSPLLQEAIAQSTQRGLG
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2, NAD(P)H dehydrogenase subunit 2, NADH-plastoquinone oxidoreductase subunit 2, NDH-1, subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: CMOB_ERWT9
Sequence: MDFTNFYQLIAKSPLSHWLETLPAQLAGWQRESLHGHFKNWDRAVEYLPALEPETLDLLHGVTADSSQLTLRQRDGIEKLLRNLMPWRKGPFSLYGVNIDTEWRSDWKWDRVLPHISSLAGRTVLDVGCGSGYHMWRMLGAGARLVVGIDPMQLFLCQFEALRKLLGNDQRAHLLPLGIEQLPELKAFDTVFSMGVLYHRRSPLDHLHQLKNQLVSGGELVLETLVIDADDQQVLVPGERYAQMRNIYFIPSAGALKNWLEKCGFVNVRIVDHSFTSTDEQRRTSWMTSESLAEFLDPDDPTKTIEGYPAPLRAVLVATKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: WETA_ASPOR
Sequence: MFAQPFDHSFNNDDLFSQYVNIDGSSTDGNKDVSFPSDFDQFFSLDSLSSNCGEQSPIISTSKQQTHPSPQWAKDFWSLPPDAPSSLGQAPLAFQDTVHPSAVSDLNVNLEASSTTCPAETRSSPTTPPGTPRRKPKSALVTPKSIQRHREPNGRRGLQHKQSFSPSLTRPSQFQKGRMAYQEAWAHRLQNLNFLRSADDRFPLSPPPSDILPQQENIAADNSAVHIHHSGDSTEMHHHFDTSIFTPSPAISMPSPCTGVLSRQQARYLNHSNNSTVTSSPPSADDIFPSPHSSDPQSMSSWHSDALGTPGLFTPDLQSHDAQAWWPPMNARVPQRQPSYQQVVASPPPQQPIQNTTHQHDLANSQHDILQGGLMIQMDPSAYDMTATANSSFSSTTMAPTASSCQENHTYSHVPTAHAKYVDASSFATPQLHPQSRSPSLSPRADRSPKNGLAMHHSITMKAQRRQPGRKISSNSMNVPKPVKGLNGSGSPKGAKSVTVSFVNFTLNDSQKILTGVAPSGSSKTKARREQEARDRRRRISEAALNAVRKAGGDVEALEAVMF
What is the function of this protein?
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (PubMed:19850144).  They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity).
What are the official names of this protein?
Developmental regulatory protein wetA.
What is the protein family that this protein belongs to?
Belongs to the wetA family.
Protein: CAP_YEAST
Sequence: MPDSKYTMQGYNLVKLLKRLEEATARLEDVTIYQEGYIQNKLEASKNNKPSDSGADANTTNEPSAENAPEVEQDPKCITAFQSYIGENIDPLVELSGKIDTVVLDALQLLKGGFQSQLTFLRAAVRSRKPDYSSQTFADSLRPINENIIKLGQLKESNRQSKYFAYLSALSEGAPLFSWVAVDTPVSMVTDFKDAAQFWTNRILKEYRESDPNAVEWVKKFLASFDNLKAYIKEYHTTGVSWKKDGMDFADAMAQSTKNTGATSSPSPASATAAPAPPPPPPAPPASVFEISNDTPATSSDANKGGIGAVFAELNQGENITKGLKKVDKSQQTHKNPELRQSSTVSSTGSKSGPPPRPKKPSTLKTKRPPRKELVGNKWFIENYENETESLVIDANKDESIFIGKCSQVLVQIKGKVNAISLSETESCSVVLDSSISGMDVIKSNKFGIQVNHSLPQISIDKSDGGNIYLSKESLNTEIYTSCSTAINVNLPIGEDDDYVEFPIPEQMKHSFADGKFKSAVFEHAG
What is the function of this protein?
The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras.  The C-terminal domain is required for normal cellular morphology and growth control.
What are the official names of this protein?
Adenylyl cyclase-associated protein, CAP.
What is the protein family that this protein belongs to?
Belongs to the CAP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch. Note=Cortical actin patches.
Protein: SBMC_EDWI9
Sequence: MQVRIVSLAAQPLFVLRVQGPFAQSLGPGFERLMAWSARHGLRGQWMALYYDNPREVAPDALRADVALTTASVTLPSDGEAYGIRRGALAGGLYALAQVRVTDNDFATPWIALFDQALPACGYRPDGGPCFERYLSDGRGSGEWLLELGVPVRKN
What is the function of this protein?
Inhibits the supercoiling activity of DNA gyrase.  Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase.  It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
What are the official names of this protein?
DNA gyrase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_STRPI
Sequence: MSAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEAYDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHRIKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: EFP_STAAM
Sequence: MISVNDFKTGLTISVDNAIWKVIDFQHVKPGKGSAFVRSKLRNLRTGAIQEKTFRAGEKVEPAMIENRRMQYLYADGDNHVFMDNESFEQTELSSDYLKEELNYLKEGMEVQIQTYEGETIGVELPKTVELTVTETEPGIKGDTATGATKSATVETGYTLNVPLFVNEGDVLIINTGDGSYISRG
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMX_BACSU
Sequence: MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYYLADPITRQWGD
What is the function of this protein?
Part of a major quorum-sensing system that regulates the development of genetic competence (PubMed:8168130, PubMed:11751817, PubMed:16091051, PubMed:12067344).  Acts through the activation of the two-component regulatory system ComP/ComA composed of a sensor histidine kinase, ComP, and a response regulator, ComA (PubMed:8168130, PubMed:16091051).  Activation of ComA leads to the direct regulation of over 20 genes and expression of over 150 additional genes, including those involved in competence development, appears to be controlled indirectly (PubMed:16091051).  Under certain conditions plays a role in sporulation (PubMed:8168130).
What are the official names of this protein?
ComX pheromone, Competence pheromone.
What are the subcellular locations of this protein?
Secreted.
Protein: CYB_MYOEM
Sequence: MTNIRKSHPLLKIINSSFIDLPAPSNISSWWNFGSLLGICLALQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWILRYLHANGASMFFICLYLHVGRGLYYGSYMYTETWNVGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFLLPFIISAMVMVHLLFLHETGSNNPTGIPSNMDMIPLHPYYTIKDILGLLLMITMLLMLVLFSPDMLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVMALVLSILILIIIPLLHTSKQRSMIFRPLSQCLFWLLVADLLTLTWIGGQPVEHPYVIIGQLASILYFSIIIILMPLTSLVENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MSRA_ECOL6
Sequence: MSLFDKKHLVSPADALPGRNTPMPVATLHAVNGHSMTNVPDGMEIAIFAMGCFWGVERLFWQLPGVYSTAAVYTGGYTPNPTYREVCSGDTGHAEAVRIVYDPSVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAAMLAADDDRRITTEIANATPFYYAEDDHQQYLHKNPYGYCGIGGIGVCLPPEA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: Y096_STAAM
Sequence: MKRLNKLVLGIIFLFLVISITAGCGIGKEAEVKKSFEKTLSMYPIKNLEDLYDKEGYRDDQFDKNDKGTWIINSEMVIQPNNEDMVAKGMVLYMNRNTKTTNGYYYVDVTKDEDEGKPHDNEKRYPVKMVDNKIIPTKEIKDKNIKKEIENFKFFVQYGNFKDLSKYKDGDISYNPEVPSYSAKYQVTNDDYNVKQLRKRYDIPTNKAPKLLLKGTGNLKGSSVGYKDIEFTFVEKKGENIYFSDSLHLEPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SAV0096.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: COX2_MICTV
Sequence: MAHPAQLGFQDAASPIMEELMYFHDHTLMIVFLISSLVLYIISLMLTTELTHTSTMDAQEVETVWTILPAVILILIALPSLRILYMMDEITTPSLTLKTMGHQWYWSYEYTDYESLCFDSYMTPPLELDPGELRLLEVDNRVVLPTEMSIRMLISSEDVLHSWTVPSLGVKTDAIPGRLNQATLMTSRPGIYYGQCSEICGANHSFMPIVLELVPLKHFEEWLLSTL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CMR5_THEMA
Sequence: MGTCLEVMKMKTLSLELAKLAMNLVEEVEKDKRDDYLRDVKGLGSMIVQNGLMGTILFLKKKGKNKVVDHLGKMIEHLTLEDGIVERLMENEFLDARTYLKAQIAALECAKWLKRCGEVLLGGEENETT
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Part of the Cmr ribonucleoprotein complex (By similarity).
What are the official names of this protein?
CRISPR system Cmr subunit Cmr5, CRISPR type III-B/RAMP module-associated protein Cmr5.
What is the protein family that this protein belongs to?
Belongs to the CRISPR system Cmr5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCXN9_MESEU
Sequence: ARDGYIANDRNCVYTCALNPYCDSECKKNGADSGYCQWFGRFGNACWCKNLPDKVPIRIPGECRG
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Sodium channel neurotoxin MeuNaTxalpha-9.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AL7A1_DICDI
Sequence: MTTFNEYPFLAELGIKAENNDGVFNGKWGGAGEIIKCLNPTNNKVIATVRGAAPEEYETCIQAMLAAKVKWALTPAPRRGEIVRLIGQAMREKIEPLSKLISLEMGKIYIEAKGEVQEFIDVCDYATGLSRSINGQVMPSERPNHILMETWNPLGLVGIITAFNFPCAVLGWNAAISMICGNVQLWKGASTTSLITLAVSKIIEKVLVENDVDPAVCCVLIGPGRTVGEQMIQDKRFGLISFTGSTEVGRRISSTVHGYFGKTILELGGNNAIVVAEDADIELVLRAVLFASVGTTGQRCTTCRRLFVHESLYDTILERLTKAYKTIKIGNPLEEGVLVGPLHTQSAVKEFTEGLEEIKKQGGKVVIGGNKLDISGGNFVEPTVVAIEHDAPIVKTELFVPILYIMKFKNLDDAFAWNNEVPQGLSSSLFTNNQKNIFKWLGPTGSDCGIVNVNVATNGAEIGGAFGGEKETGGGRESGSDSWKQYCRRSTNTINYGNTMPLSQGINFN
What are the official names of this protein?
Putative aldehyde dehydrogenase family 7 member A1 homolog, Antiquitin-1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: HISZ_OCEIH
Sequence: MINYNFRNRTSFPEDFLKKANVIKQIQNRFYTYGYDQIETPLFEDYDMYSNVQGTVQQDDMVKVIHSSGRVLVLRPDVTIPITRQYVETDMTSHYQRFSYCLDIFRFNETQQAYRTQAGVEFFGDESPEADAEVIALAIDSLKDLKIAPFKIEIGHSGIYKELLEQANLTDQEQQTLHALIQSKNISETSSFLDHLSIDQDLKQKIELIPMLYGDPSTVIKRAQAIVTNETMQQVVDTLFNVYSLLKDDQIEEYISFNLGLINNMNYYSGIIFQGFTEQIGQPILMGGRYDHLSSQFENEIPAVGFAFEIDKLLTLITPGDQPLITQADFLIEYQPNCRQDALLLARRLRQANKKVIIQPTESSSKIKASNIILVDSNSYQLKSSDIQTTFSSIDQTLQHVLKKR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_THESQ
Sequence: MRMKDLYAPTLKETPSDVETVSHEYLLRGGFIRKTAAGIYTYLPLGRRVLLKIENIVREEMNRIGAQEILMPILQPAELWKQSGRWDDYGPEMMKLKDRHERDFTLGPTHEEIVTDLVKNELRSYRQLPLVVYQVANKYRDEIRPRFGLLRAREFIMKDAYSFHSSWESLDETYELFKEAYSRIMERLGVKYMVIEAETGAIGGNASHEFVVPAKIGETNVLFCEKCGYQASDEKAEYKGEYTQEQEEEKPFKKVPTPGVKTIEEVSEFLGVPPSKIVKSLLYKGREGYVMVLIRGDLELNEAKLKAHLKDQSLRMATPEEILKDFGVPVGFIGPIGVDVKKVADHSVRGLKNFVVGGMEEDTHYVNANHPRDFKVDEWYDLRTMVEGDPCPVCGEPLKATKGIELGHIFKLGTKYSEAMKAYFMDENGEMKPFIMGCYGWGVSRTMAAVVEHFHDENGMIWPLSIAPYTVVVDILNMNDAEQKQVGEKIYQVLSEKGEEVVLDDREVSPGFKFKDADLIGFPIRINVGRSLKEGVVELKKRYSKELVKVNIKNGFGTLLETLEKMKREYDPKEAAR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB1B_MACFA
Sequence: MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDRESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLKIDSTPVKPAGGGCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity).  Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity).  Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.  Required to modulate the compacted morphology of the Golgi.  Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).
What are the official names of this protein?
Ras-related protein Rab-1B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Lipid-anchor; Cytoplasmic side. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). Co-localizes with MTMR6 to the endoplasmic reticulum- Golgi intermediate compartment and to the peri-Golgi region (By similarity).