PharMolix/UniProtQA huggingface dataset:
Protein: CAPP_STUS1
Sequence: MAKIIDARLRDNVHLLGELLGNTIRAQHGDQFFDKIERIRKGAKAARKGSAEGAQLLAETLDSLDESELLPMTRAFNQFLNLANIAEQYHQVRRRAAGEPAPFEIGVFADLIERLKAAGHDNEFIARQVSRLEIELVLTAHPTEVSRRTLIQKYDAIAQQLAARDHTDLSDAERASIELSLQRLIAEVWHTEEIRRNRPTPVEEAKWGFAAIENSLWKAVPNVLRQTDATLHRLTGLHLPLEAAPIRFASWMGGDRDGNPNVTAMVSREVLLTARWVAADLYLREIEGLITALSMREASDELLRQSGDSAEPYRVLLKPLRQRLRATREWARAAIEHGQPAPAEVLQDCAELRRPLELCYRSLHACGMGVIADGALLDCLRRLAVFGLFLVRLDIRQDAARHAAALAEITDYLGLGDYQQWDEQKRLDWLQHELANRRPLLPAHYHPSADTAEVLATCAVIAEAPAASLGSYVISMAHAASDVLAVQLLLKEAGLQRPMRVVPLFETLDDLNNAAPTIDRLLSLPGYRQRLHGPQEVMIGYSDSAKDAGTTAAAWAQYRAQEQLVEVCREHGVELLLFHGRGGTVGRGGGPAHAAILSQPPGSVAGRFRTTEQGEMIRFKFGLPDIAEQNLNLYLAAVLEATLLPPPPPEPGWRETMDRLAAEGVAAYRGVVREHPLFVDYFRQATPELELGRLPLGSRPAKRREGGVESLRAIPWIFAWTQTRLMLPAWLGWEQALHGALQRGEGERLAEMRARWPFFSTRIDMLEMVLAKADADIARRYDERLVQPELLSLGSDLRDRLSQVIEAVLSLTGQSDLLDHSPKTQEAFSLRNTYLDPLHLMQIELLARSRQRQGPAESPLEQALLVSVAGIAAGLRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: GCST_NEIMA
Sequence: MITLKTTPFHQAHQDAGAKLVDFAGWELPIHYGSQIAEHEAVRTDAGMFDVSHMLVTDVAGANAKAFFRKLIANDVAKLAFVGKALYSALLNDNGGVIDDLIVYRTNEAETQYRIVSNGATREKDTAQFHKVGQEFGVSFNPRYDLGMLAVQGPKAIEKLLTVKPEWADVVHNLKPFQGADLGNDWFVARTGYTGEDGVEVILPGTEAVAFFKALQAAGVQPCGLGARDTLRMEAGMNLYGNDMDDDTSPLEAGMGWTVDLKDESRDFVGKAALLALKEKGVAVKQVGLLLGKGGILRAHMEVLTDKGKGETTSGVFSPSLKQSIAIARVPKDFDGDTAKVLIRGKEADVRVLKLPFVRNGQKQFD
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: Y3453_PSEAE
Sequence: MSTEPNSPFVDDPLSAVDARILGSLVEKQATTPETYPLTLNALVLACNQKTSRDPVMNLTPGQVGQSLRQLEGRGLVRLVMGSRADRWEHTLGKGLELVAPQVALLGLLFLRGPQTLNELLTRSNRLHDFDDVEQIRHHLERLAGRGLAVHLERRAGQREERYMHLLGSQADLEAAVEAMGSDPERAAPAALSADAEARIAELETRLAALEERLARLEGGA
What are the official names of this protein?
UPF0502 protein PA3453.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: LOLD_SACD2
Sequence: MSTPVIKCLNVVKGYSEGPQKVEVLRGVNLQIEQGQHIAIVGASGSGKSTLLNVLGGLDKPDAGEVWVNEKAFSSLNDNKRGLVRNQELGFVYQFHHLLPEFTALENVMMPCLIAGVKKAQAKQKAEALLDKVGLSHRLDHKPAELSGGERQRVAIARALVNEPACVLMDEPTGNLDTENAESIQSLMKELSAQLQTSFIVVTHDLVLANTMNQVYRLEAGVLNKQGQ
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PDXJ_AQUAE
Sequence: MRLGVNVDHVATVRQARRTFEPSPVFAALIAQQAGADQITLHLREDRRHIQDRDLELIKELITIPVNLEMAPTEEMREIALRVKPDRITLVPERREEITTEGGLDVVSLKEKLKEYLKPIKEAGIEVSLFIEAQKEQIDASVEVGADAIEIHTGRYANLWNEHRFEEAKEELNRIKEAAIYAKEKGLKVYAGHGLTYHNVKDFVRELKGYVEELNIGHSIVANAVIFGFERAVKEMLNLIKT
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOC_CUPNH
Sequence: MAKLDILKAALEKALGKRVQNLIEATGELTLIVKADDYLEVARILRDDPSLRFEQLIDLCGVDYSEYGDGAWDGLRFAAVSQLLSITHNWRLRVRVFAPDDDFPVLPSLIDVWNGVNWFEREAFDFYGIVFDGHPDLRRILTDYGFVGHPFRKDFPVSGFVEMRYDPEQKRVIYQPVTIEPREITPRVIREDNYGGLH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FLOA_ACET2
Sequence: MDGIAFILIVGAILVFISLFFAIVPVGLWISAFAANVRVSIFTLIGMRLRRVVPSRVINPLIKATKAGINVSINKLEAHYLAGGNVDRVVNALIAAQRANIPLEFERAAAIDLAGRNVLEAVQMSVNPKVIETPVVAAIAKDGIELRAKARVTVRANIDRLVGGAGEQTIIARVGEGVVTTVGSATDHKQVLENPDAISKTVLSKGLDAGTAFEILSIDIADIDVGRNVGAQLQTDQAEADKRIAQAKAEERRAMAVAREQEMKAMVQEMRAKVVEAEAEVPKALAAALREGKIGVLDYYHLQNLIADTQMRDSISKMSKHDDSSSDKK
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: RL22_HELPS
Sequence: MSKALLKFVRLSPTKARLIARQIQGMNAELAIASLEFTPNKAARVLSKVVASAVANGSLDAKSALIVSCRVDAGPVLRRSIPRAKGRATAIRKPTSHVFVEVAEGKEMKSSKSHKKNQAEGK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: HEM3_PELPD
Sequence: MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKGLFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSRAARFSHLPPGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLTQRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQGGCQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGRAILEEVYQREI
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PA1_SALTY
Sequence: MRAILRGLLPATLLPLAAYAQEATIKEVHDAPAVRGSIIANMLQEHDNPFTLYPYDTNYLIYTNTSDLNKEAISTYNWSENARKDEVKFQLSLAFPLWRGILGPNSVLGASYTQKSWWQLSNSKESSPFRETNYEPQLFLGFATDYRFAGWTLRDVEMGYNHDSNGRSDPTSRSWNRLYTRLMAENGNWLVEVKPWYVIGSTDDNPDITKYMGYYQLKIGYHLGEAVLSAKGQYNWNTGYGGAEVGLSYPVTKHVRLYTQVYSGYGESLIDYNFNQTRVGVGVMLNDIF
What is the function of this protein?
Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3. 1. 1. 4) and phospholipase A1 (EC 3. 1. 1. 32) activities.
What are the official names of this protein?
Phospholipase A1, Detergent-resistant phospholipase A, DR-phospholipase A, Outer membrane phospholipase A, OM PLA, Phosphatidylcholine 1-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A1 family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein. Note=One of the very few enzymes located there.
Protein: SDE2_RAT
Sequence: MAEAAVLAWVRGPGTAWKALPCASVGCSVRDVIYRHCEEQEIPVECFFVKCNGVLVAAGDKVCHGAVYSLEPRLRGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWVKQQAEREAEKEQRRLERLQRKLAEPAHCFASPDYQRQCHEMAERLEDSVLKGMQAASSKVVSAEVTETRKRPNRSKTDQGAGAKKKRCFWLGMEGLEAAEGSSTGSSDDSEDDDHEDAPGTSGPSCCARENGSDGGEVAADSPGSVQSSGSGTRSESPKELQNPMTEPGQGILENTGTEPGETSTREHNERKTVTVTETEETPARKETESPEPTEKGQETGVIGEDRAAMALSGEDRKSIPAATPEGSNSGDTALGVEALDLSAFSCAAELELLGLERLKCALMALGLKCGGTLQERAARLFSVRGLSKELIDPTLFAKPSKGKKK
What is the function of this protein?
Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity).  Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity).
What are the official names of this protein?
UBL fusion protein SDE2, Replication stress response regulator SDE2.
What is the protein family that this protein belongs to?
Belongs to the SDE2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DEOC_ERWT9
Sequence: MSEVKDRALRALQLMDLTTLNDDDTDAKVIALCHQAKSPAGNTAAICIYPRFIPLARKTLREQGTPEIRIATVTNFPHGNDDSEIALAETRAAIAYGADEVDVVFPYRALMAGNEAIGFELVKACKQACREANVLLKVIIESGELKEASLIRKASEIAIDAGADFIKTSTGKVAVNATPEVAEIMLRTIAAKGVQKQVGFKPAGGVRSADDAALYLKLADNILGPDWADARHFRFGASSLLASLLNAAGFNGATSDSNY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAL_SHEWM
Sequence: MANTLEQFKSITTIVADTGDIEAIKRYQPEDATTNPSLILKAAQIPDYAHLIENAIEWAKTQSSQIDQQVEDAGDKLAVNIGVEILKIVPGRISTEVDARLSFDKAGSIAKAHKLIKLYQEAGIDKSRILIKLASTWEGICAAKELEQEGINCNLTLLFSFAQARACAEAGVYLISPFVGRILDWYKKDTGLEYSATEDPGVVSVTEIYNYYKRHGFNTVVMGASFRNTGEIIELAGCDRLTIGPALLEEMANSQTEVVRKLIPAETTVEAGEPLTEAQFRWEFNENPMAVEKLAEGIRNFAIDQGKLEVMLKEKLTS
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_KLULA
Sequence: MTYPERKAFVSRITNETKIQIAISLNGGPISIENSILQREESDAAKQVTGSQIIDIQTGVGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGHVRGVKRFGSGYAPLDEALSRAVVDLSNRPYAVIELGLKREKIGDLSCEMIPHFLESFAEAARITLHVDCLRGFNDHHRSESAFKALAIAIKEAISSNGTNDVPSTKGVLM
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
Protein: PAP1_VAR67
Sequence: MNRNPDHNTFPNITLKIIETYLGRLPSVNEYHMLKLQTRNIQKITVFNKDIFVSLVKKNKKRFFSDVDTSASEIKDRILSYFSKQTQTYNIGKLFTIIELQSVLVTTYTNILGVLTIKAPNVISSKISYNVTSMEELARDMLNSMNVAVIDKAKVMGRHNVSSLVKNVNKLMEEYLRRHNKSCICYGSYSLYLINPNIRYGDIDILQTNSRTFLIDLAFLIKFITGNNIILSKIPYLRNYMVIKDENDNHIIDSFNIRQDTMNVVPKIFIDNIYIVDPTFQLLNMIKMFSQIDRLEDLSKDPEKFNARMATMLEYVRYTHGIVFDGKRNNMPMKCIIDENNRVVTVTTKDYFSFKKCLVYLDENVLSSDILDLNADTSCDFESVTNSVYLIHDNIMYTYFSNTILLSDKGKVHEISARGLCAHILLYQMLTSGAYKQCLSDLLNSMMNRDKIPIYSHTERDKKHGRHGFINIEKDIIVF
What is the function of this protein?
Polymerase that creates the 3'-poly(A) tail of mRNA's.
What are the official names of this protein?
Poly(A) polymerase catalytic subunit, Poly(A) polymerase large subunit, PAP-L, VP55.
What is the protein family that this protein belongs to?
Belongs to the poxviridae poly(A) polymerase catalytic subunit family.
Protein: CYB_BALBO
Sequence: MTNIRKTHPLMKIVNDTFVDLPTPSNISSWWNFGSLLGLCLITQILTGLFLAMHYTPDTTTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLYAHMGRGLYYGSYAFRETWNIGVILLFTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIILALAMVHLIFLHETGSNNPTGIPSDMDKIPFHPYYTVKDILGALLLILTLLMLTLFAPDLLGDPDNYTPANPLSTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILILALIPMLHTSKQRSMMFRPFSQFLFWVLVADLLTLTWIGGQPVEHPYVIVGQFASILYFLLILVLMPATSLIENKLMKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DCD_CAMJR
Sequence: MGLKADNWIRKMALEHKMIEPFCEANIGKGVVSYGLSSYGYDIRVGREFKIFTNVNSTVVDPKNFVEENVVDFEGDVCIVPANSFTLARTIEYFKMPDDVLAICLGKSTYARCGIIVNVTPFEPGFEGHITIEISNTTPLPAKIYANEGIAQVLFLQGDEKCDTTYKDKKGKYQAQTGITLPRILK
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: HIS2_GRABC
Sequence: MMVKAVKKKTVTKINKKTSAPAAVKIKSRRLSPLADIDPDNAVQVLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIEAVSGDKEALIGESADVLYHLLVLWVAVGVEPAEVWRELTKREGISGIAEKASRAKILPRAAGLKTTKIP
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI75_MOUSE
Sequence: MAHVEVLARLQKETKCPICLDDLTDPVTVECGHNFCRSCIKDFWAGQQATSSCPVCRHQCQHRNLRSNAQLGNMIETAQLLQGMENKRHESSTSCERHNQALTLFCEDDLQLLCDQCVEPESHGRHQVLSITEAASLHRKHLQDYSKLLKWEVKEIQGLMSALNKRTVTLREQAEAQRSQLTSECEKLMRFLDQEERAAFSRLEDEEMRLEKRLLDNIAALEHHGSSLRDLLRHLMLTGELSEAKMLSTVKDFYLNCRRQLISPSIFPVQLRRVEYSFPLQYSALQKVIQHFTDNVTLDLKTAHPNLLISKDRTCVTFTKKRQRIPGSSSFTKSPVVLGIPHFNSGRHFWEVQVGKKPKWAIGICKADSSIGERQSPNPWGYWRIVWQGDSFNVSGADPDSRLKAARATSIGVFLDYELGEVSFYGMPEKCHLYTFRDTFSGPVCPYFYIGPQSEPLRLCSATDSEC
What is the function of this protein?
May play a role in female meiosis.
What are the official names of this protein?
Tripartite motif-containing protein 75.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle.
Protein: BSPRY_MOUSE
Sequence: MSADVSGTESGSESGPEPEPGPEPGPESRPESRPKPGPGPEPRPESGPEPGPRSGLRRGPKQGSERSQLCPEHFEPLSWFCLSERRPVCATCAGFGGRCHRHRIRRAEEHAEELRNKIVDQCERLQLQSAGISKYMAEVLQGKNQKAVVMASAARDLIIQRLSLVRSLCESEEQRLLEQVHGEEERAHQSILTQRAHWVDAVQKLDTLRTNMVDMITHLDDLQLIQREQEIFERAEEAEGILDPQDSEKLSFNEKCAWSPLLTQLWAASVLGSLSGVEEVLIDERTVSPLLHLSEDRRTLTFIAKKSKVCSDEPERFDHWPNALAATAFQTGLHAWIVNVKHSCAYKVGVASDQLPRKGSGNDCRLGHNAFSWVFSRYDQEFCFSHNGYHEPLPLLRCPAQLGMLLDLQAGELVFYEPASGTVLHIHRASFPQVLFPVFAVADQLISIVRGPLATVRLDSPPHHPCRSGHASR
What is the function of this protein?
May regulate epithelial calcium transport by inhibiting TRPV5 activity.
What are the official names of this protein?
B box and SPRY domain-containing protein.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Apical domain of kidney distal tubular cells.
Protein: MOD1_CAEEL
Sequence: MKFIPEITLLLLLFVHSTQAKGKRRKCPEGAWSEGKIMNTIMSNYTKMLPDAEDSVQVNIEIHVQDMGSLNEISSDFEIDILFTQLWHDSALSFAHLPACKRNITMETRLLPKIWSPNTCMINSKRTTVHASPSENVMVILYENGTVWINHRLSVKSPCNLDLRQFPFDTQTCILIFESYSHNSEEVELHWMEEAVTLMKPIQLPDFDMVHYSTKKETLLYPNGYWDQLQVTFTFKRRYGFYIIQAYVPTYLTIIVSWVSFCMEPKALPARTTVGISSLLALTFQFGNILKNLPRVSYVKAMDVWMLGCISFVFGTMVELAFVCYISRCQNSVRNAERRRERMRNSQVWANGSCRTRSNGYANGGSVISHYHPTSNGNGNNNRHDTPQVTGRGSLHRNGPPSPLNLQMTTFDSEIPLTFDQLPVSMESDRPLIEEMRSTSPPPPSGCLARFHPEAVDKFSIVAFPLAFTMFNLVYWWHYLSQTFDQNYQ
What is the function of this protein?
Functions as a 5-hydroxytryptamine (serotonin) receptor (PubMed:11100728, PubMed:12783521, PubMed:23023001).  This receptor is a ligand-gated anion-specific ion channel, selective for chloride ions (PubMed:11100728, PubMed:15878844).  Relays a long-range endocrine signal from the body cavity neurons to modulate distal adipose triglyceride lipase atgl-1 function, via the nuclear receptor nhr-76 (PubMed:24120942).  Together with the G-protein coupled serotonin receptor ser-1 involved in male mating behavior (PubMed:16291940).  May mediate an inhibitory effect of serotonin on egg laying (PubMed:16291940).  Involved in regulating locomotory behavior, perhaps by modulating interneuronal signaling, acting in concert with G-protein coupled serotonin receptor ser-4 (PubMed:19193891, PubMed:23023001).  In the presence of food, plays a role in initiating and extending dwelling behavior, perhaps acting in AIY, RIF and ASI neurons, in opposition to neuropeptide PDF-mediated signaling (PubMed:23972393).  Plays a role in aversive learning upon exposure to pathogens such as Gram-negative bacterium P. aeruginosa strain PA14; perhaps acting in interneurons in response to serotonin released by the serotonergic ADF neurons (PubMed:16281027).
What are the official names of this protein?
Serotonin-gated chloride channel mod-1, Modulation Of locomotion defective protein 1.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane.
Protein: FEN1_CANAW
Sequence: MGVKGLNQLIKEHSPSAYKEFQLKNLFGRKVAIDASMCLYQFLIAVRQSDGQQLTNEDGETTSHLSGMFYRTIKMVENNIKPVYVFDGKPPVLKGGELEKRLLRREEAQKQKTALGDEGTVEEVLKFEKRLVRVTREQNEEAKKLLQLMGIPCVDAPCEAEAQCAELARGGKVYAAASEDMDTLCYEPPFLLRHLTFSEARKMPIDQIEYKDAIAGLDMTKEQFIDLCILLGCDYCESIKGIGQATAFKLIKEHGSLDNIVEWIKNNKTKYTLPENWPFDEARQLFMNPEVTNASEISLKWKEPDVDGLIEFMVKQKGFSEDRIRSGAEKLKKGLKGGVQGRLDGFFKVVKTDDKKRKADPKESKASKKKKK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: GPMI_BACVZ
Sequence: MSKKPAALIILDGFGLRNETVGNAVAQAKKPNFDRYWNQYPHQTLTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIKNAKDNDKALHLFGLLSDGGVHSHINHLFALLKLAKSEGLTKVYIHGFLDGRDVGPQTAKTYIQQLNEQVEEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSAMDVVDDSYANGIHDEFVIPSVITKENGEPVAKIHDGDSVIFYNFRPDRAIQISNTFTNKDFRDFDRGENHPKNLYFVCLTHFSESVDGYVAFKPVNLDNTVGEVLAQHGLKQLRIAETEKYPHVTFFMSGGREEEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIAADKHDAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAIIAKGGHAIITADHGNADILITETGEPHTAHTTNPVPVIVTKEGVTLREGGILGDLAPTLLDLLGVEKPKEMTGTSLIQK
What is the function of this protein?
Essential for rapid growth and for sporulation.  Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: OX2R_CANLF
Sequence: MSGTKLEDSPPCRNWSSAPELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALVGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTMLPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPASQPRGPGQQTKSRISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNVSKLSEQVVLTSISTLPAANGAGPLQNW
What is the function of this protein?
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.  Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
What are the official names of this protein?
Orexin receptor type 2, Ox-2-R, Ox2-R, Ox2R, Hypocretin receptor type 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 1104L_ASFP4
Sequence: MLVIFLGILGLLANQVLGLPTQAGGHLRSTDNPPQEELGYWCTYMESCKFCWECAHGICKNKVNTSMPLIIENSYLTSCEVSRWYNQCTYSEGNGHYHVMDCSDPVPHNRPHQLLRKIYEKEDL
What is the function of this protein?
Causes the redistribution of lumenal ER protein to an enlarged ERGIC compartment.
What are the official names of this protein?
Protein MGF 110-4L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 110 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment.
Protein: Y825_PASMU
Sequence: MIIYLHGFDSSSPGNHEKVMQLKFIDEDVRFVNYSTLHPRHDMQFLLNEVHKLVSESKDPAPLICGVGLGGYWSERIGFLCGIKQAIFNPNLFPYENMTGKIDRPEEYKDIETKCVENFREKNKGKCLVFLSKEDGILDSQRSAALLSPFYEIVWDDVETHKFKKISHHLQRIKAFKQR
What are the official names of this protein?
UPF0227 protein PM0825.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: ERC2_HUMAN
Sequence: MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDEEGIWA
What is the function of this protein?
Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release.  Seems to act together with BSN.  May recruit liprin-alpha proteins to the CAZ.
What are the official names of this protein?
ERC protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Synapse. Presynaptic active zone. Cytoplasm, cytoskeleton. Note=In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity).