PharMolix/UniProtQA huggingface dataset:
Protein: PLSX_ALKCK
Sequence: MRIALDAMGGDNAPKAHVEAAIRAVQTFPELEVTLIGNEEQIRPHLTDTTRLTVIHTTEKIEDTDKPTTAVRRKKEASMVLCVKEVKEGNADACISSGNTGALMTAGLLYVGRIKGVERPGLAPTLPTIDGNGFLLLDAGANMDASPEHLLQYAIIGDAYRRNVYQQKNPRIGLLNVGAEAGKGTELTKQAYQLLENSSLHFIGNVEARDLFAGVCDIVVCDGFSGNVVLKSVEGTAKMVFSLLKEQLTSSLPAKLAAGMLKPQFRNLKEKMDYSEYGGAGLFGLKAPVIKAHGSSDANAVFHAIRQAKEMVDNEVTKTITQKLENGGE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: PH4H_DICDI
Sequence: MESNTNSQGQGIIPQSYHSSIFFSISKGSDKIGGLLEYLEIIKKHNINITRIESRPSKTEKKDYDFFLDLEYPTENNKEVEKVIKDLEEKGVKATTLQESSNQTYAPWFPRKISDLDLFANKVLEMGSDLTSDHPGASDPVYRERRREIAKIASTYKHGDEIPRIDYTEEEIKTWGVVYNRLKELFPTNACHQHAYIFPLLEQNCGYSPDNIPQLQDISNFLQECTGWRIRPVQGLLSARDFLNGLAFRVFHATQYIRHPSVPLYTPEPDCCHELLGHVPLLADPDFADFSQEIGLASIGASDEDIQLLSTCYWFTVEFGLCKEGDTIRAYGAGILSSTGEMEHFLTDKAKKLPFNPFDACNTEYPITTFQPLYYVAESFQKAKEQMRQFADSFKKPFSIRYNPYTQSIEILDNKDKLLNICNDIRNQSEILADAISKLKA
What is the function of this protein?
Catalyzes the hydroxylation of L-phenylalanine (PubMed:18835579).  Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA (PubMed:18835579).  It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.
What are the official names of this protein?
Phenylalanine-4-hydroxylase, PAH, Phe-4-monooxygenase, Tryptophan 5-hydroxylase, TRH, Tryptophan 5-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Protein: DBH_STRGN
Sequence: MANKQDLIAKVAAATELTKKDSAAAVDAVFAAVTEYLSKGEKVQLIGFGNFEVRERAARKGRNPQTGKETKIAASKVPAFKAGKALKDAVK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.  Seems also to act as a fortuitous virulence factor in delayed sequelae by binding to heparan sulfate-proteoglycans in the extracellular matrix of target organs and acting as a nidus for in situ immune complex formation.
What are the official names of this protein?
DNA-binding protein HU.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: S45A4_MOUSE
Sequence: MKMAPQNADSESMQVQELPVPLPDPQKPRDPEAETQEETTSEGSIDRIPTRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLIGVALFLNGSAIGLALGDVPSRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGDWFQTQNQVLFFFAAVIFSVSVALHLFSIEEEQYSPQQDRGPEDPTLPGTSVQPGAPAPASRLSSLGGGMQDGSPPFPDEVQSEHELSLDYLDVDIVRSKSDSVLHMADATLDMEPQLLFLHDIEPSIFQDASYPSTPQSTSQELLRAKLPRLSTFLRESTKEDDTLLDNHLNEAKVPNGRGSPPINSLSRSKVDLKPSVTSGSMRRRRHMFHRQASSTFSYYGKIGSHCYRYRRANAVVLIKPSRSMSDLYDLQQRQRSRHRNQSGATASSGDTESEEGETETTVRLLWLSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIFKGNPQAPSNSTKWHAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCPYALLGHYHDIKEYVHHSPGNSKRGFGIDCAILSCQVYISQILVASALGGVVDAVNSIVVIPIVASVGSFLGFLTATFLVIYPEVSEEPKEEQKGLSSGPAGEGEGGAGSEKPTVLKLSRKGGLRGLVETESMV
What is the function of this protein?
Proton-associated sucrose transporter.  May be able to transport also glucose and fructose.
What are the official names of this protein?
Solute carrier family 45 member 4.
What is the protein family that this protein belongs to?
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: VA0D1_MOUSE
Sequence: MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLANEASPLTVSVIDDKLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF
What is the function of this protein?
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:12963731).  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).  May play a role in coupling of proton transport and ATP hydrolysis (PubMed:12963731).  In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).  May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit d 1, V-ATPase subunit d 1, P39, Physophilin, V-ATPase 40 kDa accessory protein, V-ATPase AC39 subunit, Vacuolar proton pump subunit d 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Note=Localizes to centrosome and the base of the cilium.
Protein: PSBA_CRYJA
Sequence: MTAILERRESASLWNRFCDWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANAGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEANSIDG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MILR1_RAT
Sequence: MGDDDTPVCLSVASCKGVSCWLDKLLLWALTLSITLRNTAVDCRRVDRNGLLSPNLNSSMSVVRMGQNVSLSCSSKNTSIDITYSLFLGKRYLESKRRRGGAVDFHLRISNANESGPYKCKVNDSNSSKYSQNFNFTIIQDESCSSCLLSLLLPGVLLGLILPGLAFLIYLKYKKGCTGKTLKENESKGSGDAPTQGELYANICETQKGSEQLQEIHYTTPVFKEVAPTEQEGLEDRKDDYIYSELTY
What is the function of this protein?
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells.  Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).
What are the official names of this protein?
Allergin-1, Allergy inhibitory receptor 1, Mast cell antigen 32, MCA-32, Mast cell Ag-32, Mast cell immunoglobulin-like receptor 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NOS2_CHICK
Sequence: MLCPWQFAFKPHAVKNQSSEEKDINNNVEKDVKVHSFVKDDAKLHSLSKKQMKMSPIITSAEKHPQNGIKASNQISRCPRHVKVRNMENGSSLLDTLHLTAKEVINCRTRACQGALMTPKGLVRSTRDGPVPPAELLPQAVDFVKQYYSSFKELKIEEHLARLETVTKEIETTGTYHLTKDELIFAAKQAWRNAPRCIGRIQWSNLQVFDARDCKTAKEMFEYICRHIQYATNNGNIRSAITIFPQRTDGKHDFRVWNSQLIRYAGYQMPDGSVIGDPASVEFTKLCIELGWKPKYGRFDVVPLILQANGQDPEIFEYPPEIILEVPMEHPKYEWFKELDLKWYALPAVANMLLEVGGLEFTACPFNGWYMGTEIGVRDFCDVQRYNILKEVGRRMGLESNKLASLWKDRAVVEINVAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRVRGGCPADWVWIVPPMSGSITPVFHQEMLNYVLTPFFYYQVDAWKTHIWHDETRRPKKREIKLSILAKAVLLASLLLQKTMAARPKVTVIYATETGKSETLANSLCSLFSCAFNTKILCMDEYNISDLEKETLLLVVTSTFGNGDSPNNGKTLKNSLLTLKLLRKNIRYAVFGLGSTMYPEFCAFAHAIDQKLSQLGALQLTPVGEGDELNGQEEAFRTWAVTAFKTACDIFDIRGKNSIQLPEIYTSDDSWNPKKHRIVYDSQTMDLTKALSDIHGKNVIPMKLKFRQNLQSLKSSRVTILVKLSCETNQEVHYLPGEHIGISPGNQPELVHGLIARVKDAPPADQTIRLETCTEGGYWASEKKIPACTLSQALTYLLDITTPPTQQLLKKLSQLVTAEGDKQRLEVLCHSTEEYNKWKFYNRPNILEVLEEFPSAEVSTAFLLTQLPLLKPRYYSVSSSCDMTPREIHLTVAVVNYRTRDGQGPLHHGVCSTWLNKIALNETVPCFVRSADGFRLPKEPAKPCILIGPGTGIAPFRSFWQQRLYDLEKKGIKGGDMILLFGCRHPDMDHIYKEEVEEMKRKGVLKEVFTAYSRQPGQPKVYVQDILQNELETKVCNILHKEEGHLYVCGDVRMARDVAQTLKRMLVKKLNHTEQQAEEYFFQLKSQKRYHEDIFGAVFPHEVKRI
What is the function of this protein?
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.  NO may serve as both a paracrine and autocrine signal for modulating osteoclast bone resorption.  Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 (By similarity).
What are the official names of this protein?
Nitric oxide synthase, inducible, Inducible NO synthase, Inducible NOS, iNOS, Macrophage NOS, NOS type II, Peptidyl-cysteine S-nitrosylase NOS2.
What is the protein family that this protein belongs to?
Belongs to the NOS family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MURA_METPB
Sequence: MDRIHITGGTPLNGTIPISGAKNAALPLMIASLLTGETLELINVPRLADIAALTRILGNHGVDHMVVGKRPGQTAETGQTVRLTASNVIDTTAPYELVSTMRASFWVIAPLLARFGEAKVSLPGGCAIGTRPVDLLIMALEKLGAEIEIDGGYVVAKTKNGLRGAEITFPTVTVGGTHVALMAAALAYGTTVIDNAAREPEVVDLAECLSKMGARIEGAGTSRIVVEGVARLGGARHEVLPDRIETGTYAMAVAMTGGDVSLVNTRTELLASALDVLASTGTEITALPDGIRVRRNGGGISPADVTTDPFPGFPTDLQAQFMALMTLAKGQSRIRETIFENRFMHVQELARLGARIRLDGDLAVVEGVERLKGAPVMATDLRASVSLVIGALAAEGETQINRVYHLDRGFEALEAKLGRCGARIERVRA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_RHOBA
Sequence: MQRTLVLLKPDCVQRRLIGDVLSRFEAKGLHIVAMKLLQVTPELSKQHYAEHVEKPFYPSLEEFITSAPVVAIALEGLEVIRVVRDMLGATNGLQAAPGTLRGDYSSSRQMNLVHASDSEESAQRELDLYFNADEFCDYSLVLTPFMRADDE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_YEREN
Sequence: MGRPRRRGRDINGVLLLDKPLGLSSNDVLQKVKRLFSANRAGHTGALDPLATGMLPICLGEATKFSQFLLDSDKRYRVVARLGQRTNTSHAEGALISEREDICHTGTDDAALDSHRGSSQQVPSMYSALKHQGKPLYEYARQGIEVDREARSITVYELLFIRWEGNDLELEIHCSKGTYIRTIIDDLGELLGCGAHVSYLRRLQVATYPSDRMVTLEQLTAIVETAQAEERSPNAELDALLLPMDSAVLNFPEVNLLPTVAAYVKQGQPVHVAGAPGEGMVRITEGEERNFIGIGTIAEDGALHRNAWL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: LSRC_SHIFL
Sequence: MLKFIQNNREITALLAVVLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLTRNIDVSVGSITGMCAVLLGMLLNAGYSLPVACVATLLLGLLAGFFNGALVAWLKIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGISAIGWLTIILVAFMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFILNQTGTGLEMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAVLVFDGRLRCALERNLRRQKYARFMTPPPSVKPASSGKKREAA
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Autoinducer 2 import system permease protein LsrC, AI-2 import system permease protein LsrC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATG7_CANAL
Sequence: MSNHSDQIVKKYILNQSFVESSFFTKLSELKLEKYKLDSSYIAIHGFQTHPTKLNKFNDTPVLNLDQSSFDDTLNDSRINIPGELFNVNTIEEFKSLDKLKLLNTWGQNVYSEVTNATSFDYKLFNKFYILTYSDLKKYKFYYWVAYPTLSNTWTVESESQETDTTITQLVETELDNEYGQFFQYYGGKLHKSVQADKEHTFVFIDTCLSKDRKPSSQLKNYLYFIAYKGIKEIDLVTYRNNNLSFTQHLKLDAFTDSPKISGWERTNQGKLGPKLADLGSLINPLQLAEQAVELNLKLMKWRIAPDIDLEIIKKQKVLLLGAGTLGSYVARALLGWGVRSITFVDSGRISFSNPVRQPLFNFEDCFSDSGQGEYKALRAAENLKRVFPGVDAKGICLAVPMVGHPVTDEHKERENYETLVKLFEEHDVIFLLMDSRESRWLPTLIGAANEKIVINAALGFDSYLVMRHGVTNQKDRLGCYYCNDVVAPNDSLSDRTLDQMCTVTRPGGALMASSLAVELLVAILQHPERNLAPHDAETKFGNIPHQIRGFLHNFQQTKLFAPSYVHCSACSPRVITEFKQEGWEFVRKCLDDSQYLEDISGLTKVQQEAELAAKQLLEDLSLDDDVSNDIDEDSEWLS
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: SYC_NITHX
Sequence: MELRLYDTLTKEKRAFIPIDPSNVRMYVCGPTVYDFAHIGNARPVIVFDVLFRLLQHIYGTDHVTYVRNITDVDDKINDRAARDFPGLPLNEAIRKVTEKTAEQFQADVAALGCLPPTHQPRATEFVLPRDDGRADMVTLIKQLIARGHAYEAGGEVLFDVQSMPDYGALSGRRLEEQKAGARVAVDAHKRNPADFVLWKLSSENEPGWDSPWGRGRPGWHIECSAMSAAYLGDVFDIHGGGLDLIFPHHENEIAQSRCAHGTHTMANYWMHNGFLQVEGEKMSKSLGNFFTINELLTTEKFGGRKWPGEVLRLAMLKTHYRSPIDWTVDALEESKRILDSWYDIVGDDTEAIGEVDREVSAFLGDDLNTSAAVTRLHAIAASRIGKSGQLQIDAKRKLKVSAVMLGLLGRTKREYLETDPQVILVDSNLVAHLLSDRAAARARKDFKESDRIRDELAAMGVVLKDGKDADGKPETTWEIAR
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBE_SYNS9
Sequence: MAAGSTGERPFFEIITSIRYWVIHAVTLPSIFLAGFLFVNTGLAYDAFGTPRPDAYFQATDTKAPVVSQRYEGKAQLDVRLK
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PHT42_ORYSJ
Sequence: MASIRSCVSVNPAAAVTPVKYKSARVGAAGLDPKGLRISCSSSSSSLAAGGGDGCRDAGCASSSGRGSGVVGSVGDGWWGRRGGQRERAVAAMCSAGMEGVRHGAAAVASVPAASASALPERAKVVALVAAVMLLCNADRVVMSVAVVPFAAQYGWSSSFLGIVQSSFLWGYVFSSMVGGALADRYGGKKVMAGAAALWSLATFLTPWAASQSTIMLLAIRALFGLAEGVAFPTMSTFLPKWFPTHERATAVGISMGGFHLGNVISFLATPIIMSHIGLAGTFAFFASLGYLWLSVWLFNVESDPLDSRTISKSELQLILAGRSASKIQGSKFPSLREILSKIEMWAIIVANVVNNWGYFVLLSWMPVYFKTVYNVNLKQAAWFSAIPWAVMALSGYVAGASADFLIKSGFSVALVRKIMQSIGFIGPGVSLLCLRFAQTPSVAAVLMTIALSLSSFSQAGYFCNVQDIAPKYAGSLHGLTNGIGTVAAIVSTIGTGYFVQWLGSFQAFLTLTAVLYFSATVFYNTYATGDLIFD
What is the function of this protein?
Probable anion transporter.
What are the official names of this protein?
Probable anion transporter 2, chloroplastic, Phosphate transporter 4;2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sodium/anion cotransporter (TC 2.A.1.14) family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: ORC1_ORYSJ
Sequence: MDLSATPSRSKSGLRSSPRKPVAAPAVAQMDLSTPSKPTPRRKPKAPPVAAPMSPVTPSSVRRSSRLLETPTKVTSETPVKPTPTPKRKRAAPSPSPKTPTQSEPKRQRQRQRQRQQPKKPKKRAYYRKVVYDGGEFAAGDDVYVKRRDGAESDAEDPEAEECRVCFRAGAAVMVECDVCLGGFHLRCVRPPLRRVPEGDWACPYCEAERAGKAIERPKPPEGKRIVRTAKEKLLSSDLWAARIESLWREPDGIFWAKVRWYIIPEETAAGRQPHNLRRELYRTNDLADIEMETILRHCYVMSPKEFKDASDQGDDVFYCEYEYDIHWHNFKRLADIDDEPETKEDPGDEPYNAGNDYVSDSDEDSEYDEEEEPTKCSSARTHQSHALAANLRKGRTYGLQKIGIRKIPEHVRCHQKTNLEKAKATLLLATLPKSLPCRDKEMEEISAFVKDAICNDQCLGRCLYIHGVPGTGKTMSVLAVMRRLRSELDSGNLRPYSFIEINGLKLASPENIYKVIYEQLSGHRVGWKKALHYLTEHFSGGTKIGKQANQPIILLIDELDLLLTRNQSVLYNILDWPTRPNSNLVVIGIANTMDLPEKLLPRISSRMGIQRLCFGPYNYRQLQEIITSRLKGIDAFEDQAIEFASRKVAAMSGDARRALEICRRAAEFADYRVKQSGHTSVNRGKNVVCMGDIEAAIQEVFQAPHIQVMKNCPKFGKIILVAMVHELYRSGLGEVMFDKLAATVLSWCHVNRELLPGYDTLLKICCKLGEGKIILCEEGTKHKLQKLQLNYPSDDVTFALKESPDIPWLSKYL
What is the function of this protein?
Essential protein (By similarity).  Component of the origin recognition complex (ORC) that binds origins of replication.  It has a role in both chromosomal replication and mating type transcriptional silencing.  Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity).  H3K4me3 effector that regulates positively the transcription of a subset of genes (By similarity).  Required for cell proliferation (PubMed:10996242).
What are the official names of this protein?
Origin of replication complex subunit 1, OsORC1.
What is the protein family that this protein belongs to?
Belongs to the ORC1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MEF2_CAEEL
Sequence: MGRKKIQITRIQDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIVFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNNDIMEALNRKEGNQGGGNSDDESPGPSTSPVIQITMPAVVNGHSSNNSVASAASASAAAVAAAAAAVAAVEGTSSGAAAAAAALQASNAQRHHNLNLYQNLIFNPNYTRHLNQRNDPLSSTSVAPSSSSSKHLDFPPSTSFAYDTSRLHPIAAADADCDLVPSSRAAADQNIWSSALQQRPVSQPAPSISNSSTNGISNGTSSLLSPNVSSLNGHSVLDLGGPNLPYKLDPNTYVKMEPHSPPEKRPRITTEWRPQQLT
What is the function of this protein?
Transcription regulator (PubMed:17170704, PubMed:27487365).  Binds specifically to the MEF2 element, 5'-[TC]TA[AT][AT][AT][AT]TA[AG]-3' in the regulatory elements of target genes, such as chemoreceptors str-1 and srh-234 (PubMed:10882527, PubMed:17170704, PubMed:27487365).  Involved in transduction of sensory signals, together with egl-4, kin-29 and hda-4; binding to histone deacetylase hda-4 enables negative modulation of chemoreceptor gene expression in chemosensory neurons (PubMed:17170704, PubMed:18832350).  In response to starvation, negatively modulates expression of chemoreceptor srh-234 in ADL sensory neurons, acting in concert with basic helix-loop-helix (bHLH) transcription factors (PubMed:27487365).  Plays a role in regulating muscle sensitivity to acetylcholine (ACh) and the magnitude of presynaptic ACh release via a retrograde signal, perhaps by indirectly decreasing Ras-related protein Rab-3 activity (PubMed:18510933).
What are the official names of this protein?
MEF2 transcription factor homolog.
What is the protein family that this protein belongs to?
Belongs to the MEF2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RN121_MOUSE
Sequence: MAAVVEVEVGGGALAERELDEVDMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWIFFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGISYILGLE
What is the function of this protein?
E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity).  May regulate the unfolded protein response to reduce endoplasmic reticulum stress (By similarity).
What are the official names of this protein?
E3 ubiquitin ligase Rnf121, RING finger protein 121.
What is the protein family that this protein belongs to?
Belongs to the RNF121 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NUSA_METVS
Sequence: MRIKLNTEDIMRISLFEKMTGANVIDSTSDDEKIVFVVKEGDIGAAIGKGGENVKNATDKFGKKIDLIEYSEDLKQFIKNIFAPIELEDVWVKKFGNDLVVYVRVHPRLRRAIIGDKGKNIDRAVDIAGRLAGVKNIKVVAGLRKDADNRPKKDEIPEKAAESSENVQAEENQ
What is the function of this protein?
Participates in transcription termination.
What are the official names of this protein?
Probable transcription termination protein NusA.
What is the protein family that this protein belongs to?
Belongs to the NusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBADH_PSEUC
Sequence: MYEAIGHRVEDGVAEITIKLPRHRNALSVKAMQEVTDALNRAEEDDSVGAVMITGAEDAFCAGFYLREIPLDKGVAGVRDHFRIGALWWHQMIHKIIRVKRPVLAAINGVAAGGGLGISLASDMAICADSAKFVCAWHTIGIGNDTATSYSLARIVGMRRAMELMLTNRTLYPEEAKDWGLVSRVYPKDDFREVAWKVARELAAAPTHLQVMAKERFHAGWMQPVEECTEFEIQNVIASVTHPHFMPCLTEFLDGHRADRPQVELPAGV
What is the function of this protein?
Dehalogenates 4-chlorobenzoyl-CoA, 4-iodobenzoyl-CoA and 4-bromobenzoyl-CoA, but not 4-fluorobenzoyl-CoA.  Inactive towards crotonyl-CoA, alpha-methylcrotonyl-CoA and beta-methylcrotonyl-CoA.
What are the official names of this protein?
4-chlorobenzoyl coenzyme A dehalogenase, 4-CBA-CoA dehalogenase, 4-CBCoA dehalogenase, 4-chlorobenzoyl-CoA dehalogenase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.