PharMolix/UniProtQA huggingface dataset:
Protein: MNS1B_COCPS
Sequence: MKGSPVLAVCAAALTLIPSVVALPMIDKDLPSSISQSSDKTSQERAEAVKAAFRFAWEGYLEHAFPNDELHPVSNTPGNSRNGWGASAVDALSTAIIMDMPDVVEKILDHISNIDYSQTDTMCSLFETTIRYLGGMISAYDLLKGPGSHLVSDPAKVDVLLAQSLKLADVLKFAFDTKTGIPANELNITDKSTDGSTTNGLATTGTLVLEWTRLSDITGDPEYGRLAQKGESYLLNPQPSSSEPFPGLVGRTIDIETGLFRDDYVSWGGGSDSFYEYLIKMYVYDKGRFGKYKDRWVTAAESTIEHLKSSPSTRKDLTFVATYSGGRLGLNSGHLTCFDGGNFLLGGQILNRDDFTKFGLELVEGCYATYAATATKIGPEGFGWDATKVPEAQAEFYKEAGFYITTSYYNLRPEVIESIYYAYRMTKDPKYQEWAWDAFVAINATTRTSTGFTAIGDVNTPDGGRKYDNQESFLFAEVMKYSYLIHSPEADWQVAGPGGTNAYVFNTEAHPVKVFSRGC
What is the function of this protein?
Alpha-mannosidase involved in the maturation of Asn-linked oligosaccharides.  Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
What are the official names of this protein?
Mannosyl-oligosaccharide alpha-1,2-mannosidase, Class I alpha-mannosidase, Man(9)-alpha-mannosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNC_SERP5
Sequence: MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANALFQRFPRVDEGDMSRMRATLVRGNTLAEMGREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQTVERLILDWYRSRLDEISPGDKQKDPKTRLQEFLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALIKLELE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCAL1_MACMU
Sequence: MDKPRKENEEEPQSAPKTDEERPPVEHSPEKQSLEEQSSEEQSSEEEFFPEELLPELLPEMLLSEERPPQEGLSRKDLFEGRPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIQAADELEEMKRVRNKLMIMHWKAKRSRPYPI
What is the function of this protein?
May be involved in transcriptional regulation.  Modulates various viral and cellular promoters in a promoter context-dependent manner.  Does not bind DNA directly (By similarity).
What are the official names of this protein?
Transcription elongation factor A protein-like 1, TCEA-like protein 1, Transcription elongation factor S-II protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family. TFA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CEBPB_RAT
Sequence: MHRLLAWDAACLPPPPAAFRPMEVANFYYEPDCLAYGAKAARAAPRAPAAEPAIGEHERAIDFSPYLEPLAPAAADFAAPAPAHHDFLSDLFADDYGAKPSKKPSDYGYVSLGRAGAKAAPPACFPPPPPAALKAEPGFEPADCKRADDAPAMAAGFPFALRAYLGYQATPSGSSGSLSTSSSSSPPGTPSPADAKAAPAACFAGPPAAPAKAKAKKAVDKLSDEYKMRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASAGHC
What is the function of this protein?
Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:1934061).  Promotes osteoblast differentiation and osteoclastogenesis (By similarity).
What are the official names of this protein?
CCAAT/enhancer-binding protein beta, C/EBP beta, C/EBP-related protein 2, Interleukin-6-dependent-binding protein, IL-6DBP, Liver-enriched inhibitory protein, LIP, Liver-enriched transcriptional activator, LAP, Silencer factor B, SF-B.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. C/EBP subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity).
Protein: PANC_SYNC1
Sequence: MDIINDIATVQSRCLQARQAGQRIAFVPTMGYLHEGHLSLMREGRKRGDLLVASIFVNPTQFGPKEDLASYPRDLERDAELVREVGVDILFHPTPATMYPNGYKTYVHVEGLTKTLCGESRPGHFRGVTTVVCKLFNIVQPDIALFGRKDFQQLAVLRRMAADLNLPVEVVGLPTVREKDGLAMSSRNVFLSAEERKQALALVDALRQARVAAHHGEHHARRLVGLVRERIGREPDAQIDYIKICDGDTLEGVDRIDANSVLLMAVRIGQTRLIDNNYILEEV
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_METVS
Sequence: MLTKRIIPCLDIKEGRVVKGTNFLELRDAGDPVELSKIYNEQGADELVFLDITASFEKRDIIIDVVKRTAEQVFIPLTVGGGIKTVEDFRRILRAGADKISINTSAVKNPELIKEASEIFGTQCVVVAIDVKRNYINDSNDKNLSGKYIFESKNGKFWFEVYIYGGREGTGIDAINWAKKVENLGAGEILLTSMDADGTKDGYDITLTKAISESVKLPVIASGGCGSSAHVVEVFKNGNADAALMASILHYRETDVQKIKKEVQKNNIPVRI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_SYNFM
Sequence: MTEKLWQGRFDQPTNRQVEDYTASIHFDNRLYRYDIEGSIAHCRMLAQCKIISHDDASLIVQGLGEIRRELERGKLHLGSSNEDIHMAIEQELMRKIGEVGGKLHTARSRNDQVALDVRLYMRDTLLQCRGLILQTQKVLVSCAEENLGVVMPGFTHLQHAQPILLSHHLMAYYEMLKRDDERFEQCFHRTNVLPLGSAALAGTTFPIDMEWTAKYLNFPRVTSNSIDAVSDRDYLIEFGAASAMLMMHVSRLAEELILWSSTEFDFIEISDAFCTGSSIMPQKKNPDVPELMRGKTGRVYGNLMALLTLTKALPLAYNRDLQEDKEPVFDTADTIISTLRLLSRLIPEIRFHRERMGEMAIQGFTLATDLADYLVKKGVPFRKAHHIVGQIVQYCLKNRKQLHDCTVEELKTFHKTIDQDVFPFLEVAGAIDQRVSIGGTATTRVVEAIEKARAELDALEQSLSS
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y826_RICPR
Sequence: MKLIKEDIDKIVRRIFAKQHPLLPKIMINWHKIVGFNFSTKALPLKIKTYTYKKQKINILLIQAEDNATAAELPYYQDIILERIKIYLGFEAIHQMNVTFYKAKSKVR
What are the official names of this protein?
Uncharacterized protein RP826.
Protein: TPS2_DICPU
Sequence: MNLTLKDFHVPNEWNVKSINDNSFIQECYQKAIEMNIYDKSDEKGKAVMYHALTVCPAFWPTVTYDQLVLSGYLMLWLILFDDDLDTVFIPDDEATEIINRTELIFLEGILPTNPTKKEEFTLFFRNQVLKMSGNRLDMFNLFLNYTIQWIHSIIPLNKTIEPHMDLFLFIRKLNVGVYPLIGLSCIFFSNDKIDQSLFLNPRWLKLCEATSIVTALYNDCVSYAKEVKGNAGVNNCLWFLQKKNNTSIQDTFKYICEKSNMYIKEFQNHEEKLLNQYNNIQPLATLLNSLKYIMNGKYYWSMNTARYASPSSPFIEIQNAVSPDNKLINNEL
What is the function of this protein?
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene (E)-beta-farnesene as major product (PubMed:30254228).  Is also able to convert FPP into delta-elemene, beta-elemene, (E)-beta-caryophyllene, 9-epi-(E)-caryophyllene, and a yet unidentified sesquiterpene (PubMed:30254228).
What are the official names of this protein?
Terpene synthase 2.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: TRMD_SYNS3
Sequence: MAPYRLDVISLAPQAFAPLPEVGVIGRAFGAKIAELHLHNPRDHAIDRHRKVDDVPYGGGAGMVLKPEPVFAAFESVPVCSRRRVLLMSPQGQPLRQVDLQRWSQDYDQLVFLCGHYEGFDERIRSLADEEVSMGDFVLTGGELPAMTIINGVVRLLPGTVGTPESLVEESHSDLLLEHSHYTRPADFRGMTVPDVLRSGDHGAVALWRQQQREQRTQERRPDLWNRWQQIQNPTPPAP
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y205_VIBCM
Sequence: MSLKQLPTESMPREKLLQRGPQSLSDAELLAIFLRTGTQGMNVLALADLLLRDFGSLRALFCASKEQFCRHKGLGEAKFVQLQAVLEMTQRYLAETLKRGDALTSPQQTKLYLSSVLRDRQREAFYILFLDNQHRVIRDEILFEGTIDAASVYPREVVKRALHHNAAAVILAHNHPSGVAEPSQADRRITDRLRDALGLVEIRVLDHFVVGDGEVVSFAERGWI
What are the official names of this protein?
UPF0758 protein VCM66_0205.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: MRAY_LACGA
Sequence: MQFSLIPFISSFALTVIFLPLFIGFMRMKHEGQVIRDEGPKWHEKKSGTPTMGGVVFMLASVISTLWVLIWQKNLNKTTWILIIAFLGYGIIGFLDDGIKLYFKRNLGLKAWQKLLGQIIIAALIIALAFSDHFAFELYIPFAGMVRNSFLFSLFVLFWLVGFSNAVNLSDGLDGLATGLSIIAYATYAWIAYQEKNWVIVAFTLSVIGGLVGFFIFNHKPAKIFMGDAGSLALGGGLATVSIFLHRPWSLLLIGIVFVLETLSVILQVISFQTTGKRIFKMTPIHHHFEMLGWSEWKVDIVFWIVGLIGSIIYLIIWG
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPB_CUSEX
Sequence: MRINPTTYGSEISLIEKKNRGRIVQIIGPVLDVAFPPGKMPNIYNALVVKGRDTEQMNVTCEVQQLLGNNRVRAVAMNDTDGLMRGMEVIDMGTPITVPVGGSTLGRIFNVLGEPVDNFGPVDTNTTSTIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEKNITESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSMMLQPRIVGEEHYETAQKVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFNLILSGELDSLPEQAFYLVGNIDEATKKAMDLKT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, plastid, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid membrane; Peripheral membrane protein.
Protein: PLS1_PHYBU
Sequence: FLISIPYSASIGGTATLTGTA
What are the official names of this protein?
Phylloseptin Bu-1, PLS-Bu1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y024_RICPR
Sequence: MNTEKLKDIKARIKDFKSYKTSNSKIQQKINPFSIALDLVSGTMVGLLIGILTDKFFNSKPLFLIIFTIIGMIAGFNIIRRK
What are the official names of this protein?
Uncharacterized protein RP024.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PANX2_HUMAN
Sequence: MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF
What is the function of this protein?
Structural component of the gap junctions and the hemichannels.
What are the official names of this protein?
Pannexin-2.
What is the protein family that this protein belongs to?
Belongs to the pannexin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: ILVC2_BIFLO
Sequence: MAATIWYEKDADLSVFDGKKVAILGYGSQGHAHALNLRDSGVDVVVGLRPTSKSVEFAKEQGLEVKPVGEAVAEADVVMILLPDQYQAAVYKKDVEPNLKPGAALAFAHGFNIHYGYIKPSEDHPVFMVAPKGPGHIVRREYAAGRGVPVVVAVEQDPDGKTWPLCLAYAKALGALRAGAIKTTFTEETETDLFGEQDVLMGGINHLCDLGFDVLTEAGYQPEIAYFEVFHELKMLVDLANEGGLNKARWSCSDTAQYGDYTSTVITEETKKRMQYQLKRIQDGSFAKEFMDDQAAGAPKFKKLQEEYSHPHLETVGPKLRAMFSWNNAEAKDKDETESFNGKIARTQVQ
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)) 2, KARI 2, Acetohydroxy-acid isomeroreductase 2, AHIR 2, Alpha-keto-beta-hydroxylacyl reductoisomerase 2, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: CID14_SCHPO
Sequence: MGKKSVSFNRNNYKKRKNERTEPLPRRIFKNDKPSKFKSKRKEKDKNSDAYDEMLLNNNFTLLDQEEPMVEIGSKKSRNDNDSEGIRDKGGVEISNKNDPYIQFGKADPLEPLEKPDLPEEAIKRGEPTILLGIPKREGRKTNPVHDKAVENNSDFIKFDWNSDEDEDSVSNDKSKNNESLKKSSKNEIPGFMRQRGRFFHEANEKSDSNRKRKRQAYELDSQSCPWHRQYKVEREVSRIFHQDILHFIDYITPTPEEHAVRKTLVSRINQAVLQKWPDVSLYVFGSFETKLYLPTSDLDLVIISPEHHYRGTKKDMFVLAHHLKKLKLASEVQVITTANVPIIKFVDPLTKVHVDISFNQPGGLKTCLVVNGFMKKYPALRPLVIIIKHFLNMRALNEVFLGGLSSYAIVCLVVSFLQLHPRLSTGSMREEDNFGVLLLEFLELYGKQFYYDAVGIAVHNGGFYFSKKKMGWLKPNQPYLLSIQDPVDFQNDVSKSSRGLLRVKATFANGFDLLTSKLYALASRIEREGVNRVKDFPSILSTILSVDEGVRQHREHMLKCYKNNPVPLEPLVEVDALASIDVDKLPLQDVGLQYVEDESDSDETDAAKDDLFKVNESIETNGHENFQKQALTSTGEQSSSNSRANPSKLFNISSDDSEDEVPIIEDTTASDEESRAKKIRKRF
What is the function of this protein?
Required for 3' polyadenylation of the 5. 8S and 25S rRNAs as a prelude to their degradation in the exosome.  Involved in the nucleolar organization to ensure faithful chromosome segregation during mitosis.
What are the official names of this protein?
Poly(A) RNA polymerase cid14, PAP, Caffeine-induced death protein 14, Polynucleotide adenylyltransferase cid14.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RIMK_PECCP
Sequence: MKIAILSRDGALYSCKRLREAAEARKHSVEIIDPLSCYMNINSAAPSVHYRGRRLDKYDAVIPRIGSQITFYGTAVLRQFEMLGSYPLNNSVAVIRARDKLHSLQLLAREGIDLPITGFAHSPDDTGDLIAMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYVREAQGKDIRCLVIGNRVVAAIERQAKAGEFRSNLHRGGSANNVKITAQERAIAIKATKTLGLNVAGVDILRADRGPLVMEVNASPGLEGIETTTGFDIAGMMIEFIEQNTQRRFATSASISKS
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: TERL_BPT4
Sequence: MEQPINVLNDFHPLNEAGKILIKHPSLAERKDEDGIHWIKSQWDGKWYPEKFSDYLRLHKIVKIPNNSDKPELFQTYKDKNNKRSRYMGLPNLKRANIKTQWTREMVEEWKKCRDDIVYFAETYCAITHIDYGVIKVQLRDYQRDMLKIMSSKRMTVCNLSRQLGKTTVVAIFLAHFVCFNKDKAVGILAHKGSMSAEVLDRTKQAIELLPDFLQPGIVEWNKGSIELDNGSSIGAYASSPDAVRGNSFAMIYIDECAFIPNFHDSWLAIQPVISSGRRSKIIITTTPNGLNHFYDIWTAAVEGKSGFEPYTAIWNSVKERLYNDEDIFDDGWQWSIQTINGSSLAQFRQEHTAAFEGTSGTLISGMKLAVMDFIEVTPDDHGFHQFKKPEPDRKYIATLDCSEGRGQDYHALHIIDVTDDVWEQVGVLHSNTISHLILPDIVMRYLVEYNECPVYIELNSTGVSVAKSLYMDLEYEGVICDSYTDLGMKQTKRTKAVGCSTLKDLIEKDKLIIHHRATIQEFRTFSEKGVSWAAEEGYHDDLVMSLVIFGWLSTQSKFIDYADKDDMRLASEVFSKELQDMSDDYAPVIFVDSVHSAEYVPVSHGMSMV
What is the function of this protein?
The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction (PubMed:11846554, PubMed:10967092, PubMed:12466275).  The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities (PubMed:12466275).  Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine.  The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging) (PubMed:8063105, PubMed:10967092, PubMed:12466275).  Once the capsid is packaged with the DNA, the terminase complex is substituted by the tail.
What are the official names of this protein?
Terminase, large subunit, DNA-packaging protein, Gene product 17, gp17.
What is the protein family that this protein belongs to?
Belongs to the Tequatrovirus large terminase family.
Protein: NHAB_ECOK1
Sequence: MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMTSAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRLQRTRQDKIRLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLSSISDNVFVGTIYINEAKAAMKSGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPB_NEIGO
Sequence: MKNYHAPDEKGFFGEHGGLYVSETLIPALKELEQAYNEAKNDPEFWAEFRRDLKHYVGRPSPVYHAARLSEHLGGAQIWLKREDLNHTGAHKVNNTIGQALLARRMGKKRVIAETGAGQHGVASATVAARFGMTSDVYMGADDIQRQMPNVFRMKLLGANVIGVDSGSRTLKDAMNEAMREWVARVDDTFYIIGTAAGPAPYPEMVRDFQCVIGNEAKAQMQEATGRQPDVAVACVGGGSNAIGLFYPYIEEENVRLVGVEAGGLDVDTPDHAAPITSGAPIGVLHGFRSYLMQDENGQVLGTHSVSAGLDYPGIGPEHSHLHDIKRVEYTVAKDDEALEAFDLLCRFEGIIPALESSHVVGSGDKTRRKMGKDQVILVNLSGRGDKDINTVAKLKGIEL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: NADK_SHELP
Sequence: MSKAFHSIGLIGKPHHSGTHKTLKRLHHWLTMQSYDVYVEERVAAEIGPQVKSVDLLQIGEYCDLAIVVGGDGNMLGAARVLARFDIGVIGVNRGNLGFLTDLPPDTFEEALGKVLQGEYETEHRFLLESEVHRHGEMKSSNTAVNEAVLHPGKIAHMIEFEVYIDDKFMYSQRADGMIVSTPTGSTAYSLSAGGAILTPNLEALILVPMFPHTLSCRPIVVDACSIIKLVVSPDNGDALEVSCDGHVTLPVLPGDEIIVRRSKERLRLIHPKGYNYFHVLRNKLGWGSKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_RHILW
Sequence: MTNVVVVGSQWGDEGKGKIVDWLSERADIVVRYQGGHNAGHTLVIDGTSYKLSLLPSGVVRPGKMAVIGNGVVVDPHALIAEIGRLEAQGVTVTPDNLRIADNATLILSLHRELDAMREDAASNSGTKIGTTRRGIGPAYEDKVGRRAIRVMDLADLDSLAGKVDRILTHHNALRRGLGVAEVSHQTIMDELTSIADRVLPFRDTVWLFLDKERRKGSRILFEGAQGSLLDIDHGTYPFVTSSNTVAGQAAAGSGMGPGSLGYILGITKAYTTRVGEGPFPTELKDAIGEFLGEKGHEFGVVTGRKRRCGWFDAALVRQSIATNGITGIALTKLDVLDGLEELKICVGYMLDGEQIDHLPASQGAQARVEPVYITLEGWKESTVGARSWADLPAQAIKYVRQVEELIGAPVALLSTSPERDDTILVTDPFED
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLK4_AEDAE
Sequence: MSFGDRIEDYEVYEILGKGGFASVYRARCLGSGTFVAIKMIDKKLMQSSGMANRVRQEVSIHSQLKHPSILELYTFFEDASHVYLVLELAENGELQRYLRETKKTFNEYEAASVLKQVVDGLLYLHSHHILHRDMSLANLLLTKQMTVKISDFGLATQLTRPDEKHMTLCGTPNYISPEVASRASHGLPADVWGLGCMLYTFLVGKPPFDTEGVKSTLTKVVMSNYTIPPYISSEARDLIDQLLKKNPAERIKLDQVLQHPFMRKATSYDSYRGGGTLASSDSGLVTMSSNGGSNRSNIPSSYGQDQRLQAPIIHQMPLRYQPISEHEYDFQESILPQQRPQSASHNKPTSDFFSGISNDPRTMAPSSPTKSPKKRLDIPPLNTARLLPNRHKTKNAILSIRSSGEVVLEFIKFKTRYKENRVVDVCRISSDGLRFVLYHPDGGKGVPIEEEPPDLPPGGADSIFSYENLPEKHWKKYQYAARFVQMVKAKTPKITYYSEKAKCQLMETLEDYEASFYSGTKIIKSPQDGVKFVDSSGIAIKTIASLSSSQNAEYQHFQQTLEHCLNIERALSAIQTGKTFPLIIGRRPANAPLTSSSSSSSSSTKENQLYSNISSPNTPQTPHQMPSFAMSTASHTSAGNPLTQRPVLSSKPVPANFSNVAMKKCTIAGVGTAVQLSQGVVQVQFLDGATLSLIPIEQGGGVTFSPAVGSPLQHYSTQDNDALLPASLREKIGQMPAILRELNAAPVPSIPFNFLEGSPRTPLTRFLR
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the mother centriole cylinder, leading to the recruitment of centriole biogenesis proteins.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase SAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: RNFB_PSEA7
Sequence: MNGVLLAIGVLLPICLASGALLGYAAVRLRVQGDPVAERVNALLPQTQCGQCGYPGCKPYAEAIAAGDRINKCPPGGEATIQALADLLDLEPEPLDAAEETPPRVAYIREAECIGCTKCIQACPVDAIVGAARLMHTVIADECTGCDLCLEPCPVDCIEMREIAPDVRHWKWPPPSPRLIASDRERAA
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: AROA_ACHSL
Sequence: MSHSASPKPATARRSEALTGEIRIPGDKSISHRSFMFGGLASGETRITGLLEGEDVINTGRAMQAMGAKIRKEGDVWIINGVGNGCLLQPEAALDFGNAGTGARLTMGLVGTYDMKTSFIGDASLSKRPMGRVLNPLREMGVQVEAADGDRMPLTLIGPKTANPITYRVPMASAQVKSAVLLAGLNTPGVTTVIEPVMTRDHTEKMLQGFGADLTVETDKDGVRHIRITGQGKLVGQTIDVPGDPSSTAFPLVAALLVEGSDVTIRNVLMNPTRTGLILTLQEMGADIEVLNARLAGGEDVADLRVRASKLKGVVVPPERAPSMIDEYPVLAIAASFAEGETVMDGLDELRVKESDRLAAVARGLEANGVDCTEGEMSLTVRGRPDGKGLGGGTVATHLDHRIAMSFLVMGLAAEKPVTVDDSNMIATSFPEFMDMMPGLGAKIELSIL
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.