PharMolix/UniProtQA huggingface dataset:
Protein: LEUC_CAMJE
Sequence: MTMAKTLYEKVFDAHVVYEGKNELPILYIDRHLIHEVTSPQAFSGLKMAKRRMARADLTLATIDHDVSTKSMDLNACSDMAKEQITTLMQNTKEFGVRLLGLGDKNQGIVHIVGPELGFTLPGVTLVCGDSHTATHGAFGALAFGIGTSEVEHVMATQTLKQAKLKTMKIECKGQFQKGVYTKDLILYLIAQYGTAKGTGYAIEFCGELIRNLSMEARMTLCNMAIEFGAKVGMIAPDEITFEYIKGKEFAPKGEEFQKYCEYWKSLRSDEGAKYDASITLDVSKIKPQISYGTNPSQVIGIDEKIPKISDFKNQSEQKSLLDALYYVNLEQDQVIEGVKIDIVFIGSCTNGRLEDLKIAADILKGRKIHKNVKALIVPGSMQVRKEAENLGLDKIFIEAGCEWRYAGCSMCLGMNDDKANSGQRVASTSNRNFVGRQGKGSITHLMSPASAAACAIEGVICDNRKYLGV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: PALH_YEAST
Sequence: MNLWRHSPEELAAYNSCHPMKLGSGVLIQLPLYDNSAVYAEDITFRSFCCERVPVYVSTVLRNSSPYRYLDEVINDWQKFIQVSDYVGGSAEYAIYAVILSITSNFVITVFLTVICCINISGRAYKRILQLLRIASLLASLNLTIFITKVLRRLEKEHNVYGVVRAHSIMHIFSDDMTFVVLDFLATLMFQFCQVGIVIRLFQRAQEKRIIFFIGVILTITANILWVIPPFANHTTKHRNDWQILRPFVYLFRIAIATSYASIVIYHIWQKKKLWFKFNQMGLLTLLTILVVLLLPGFFLADVSNLWISELGEVFNTTCYVTSTVITWEWLDRLNVLERKEEAQSILGRPIFEEEQQDYRFAKYALRVQNALTRRESQDASTDRHDTSSNSEVCDLQTISRYDPEDQISVGRSIDRMHFNDRGTYKDVALKKLGYARDKILYFTDQIVQKSVGHNNSSSSKNEKTKQRKAMVRKRLGLDKPGIYIYSTKDVVFNSDEDDDENAEDEDDDEYEVGSEGNNNSSATFTSDHIGHI
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).  Required for growth at alkaline pH.
What are the official names of this protein?
pH-response regulator protein palH/RIM21, Regulator of IME2 protein 21.
What is the protein family that this protein belongs to?
Belongs to the palH/RIM21 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VRTB_PENAE
Sequence: MAPYLQHFIAWFGKDSILSKLIQIFNPPSHSDSAKIIISDDDGRSPEPPGGEEILWRHSAPKSTQMWAFLQKVNKKYGYSLRTYQDLHHWSITHRGQFWGEAWDYCGIRHSRQYDEVVDEAAAMWPRPAWFRGARLNFAENLLFPKVPQAVSDEAIAVISVDEGGKRDFITWQDLRERVRRCQSGMRALKIQPSDRVAGYVANHSNALVAMLATASLGAIWTAVSPDTGVIGAVDRLVQIEPRLLFTDNAVIYNGRIHPVLTKTQEIITALPSLEAVVVMRTVAGVQEDLPSSPRSPAKRLTYNSFLAQGPETQKLEFVHMPAEHPLYILYSSGTTGPPKCIVHGAIGTLMQHKKEHMLQSDIQPGDRLCFVTTCMWMMWHWLVSGLASGATVVLYNGSPFYYAPSSHGTSAKDDLAMPKLVDELGITQFGASATYFSMLERRKHLPRSLTQGRLSLETLKAVYSTGSPLAPSTFRYIYQAFGSQVNLGSISGGTDIIADFGVPSPLQAVVAGEIQVIALGMAVQAWGPTGMDLSVTGEPGELVQFWGPSGASKYESSYFAKYPGVWAHGDHIQINPRTGGLIMLGRSDGTLNPKGVRFGSAEIYHVLQYHFAAQVEDALCVGRRRRQDTDEMVVLFVKMRQDQLWSLALAEAIRRTVREELSPRHVPELIIECPEIPVTANGKKVEVLVKRIVSGVEVPAAGGSGTVNADCLQWFQEWATQN
What is the function of this protein?
Malonamoyl-CoA synthetase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system (PubMed:20534346).  The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA (PubMed:20534346).  The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB (PubMed:20534346).  The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone (PubMed:20534346).  The cyclization of the last ring could be mediated by the lactamase-like protein vrtG (PubMed:20534346).  The proposed post-PKS tailoring steps are an hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF (PubMed:20534346, PubMed:24161266).  VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin (PubMed:20534346).  Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin (PubMed:24161266).
What are the official names of this protein?
Malonamoyl-CoA synthetase vrtB, Viridicatumtoxin synthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: GSTZ1_ARATH
Sequence: MANSGEEKLKLYSYWRSSCAHRVRIALALKGLDYEYIPVNLLKGDQFDSDFKKINPMGTVPALVDGDVVINDSFAIIMYLDEKYPEPPLLPRDLHKRAVNYQAMSIVLSGIQPHQNLAVIRYIEEKINVEEKTAWVNNAITKGFTALEKLLVNCAGKHATGDEIYLADLFLAPQIHGAINRFQINMEPYPTLAKCYESYNELPAFQNALPEKQPDAPSSTI
What is the function of this protein?
Acts a maleylacetone isomerase.  Also catalyzes the glutathione-dependent dehalogenation of dichloroacetic acid to glyoxylic acid.  In vitro, possesses glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide.
What are the official names of this protein?
Glutathione S-transferase Z1, AtGSTZ1, GST class-zeta member 1, Glutathione S-transferase 18, Maleylacetone isomerase, MAI.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Zeta family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: GE_PSHV1
Sequence: MMPATLAGLALAVTVATMFAQRVDSTTIHHVSGLKGKPLLFGPSLRRTLPAGGTFKWVLVLSDPCAPKPTEICVSVGHCFYDLVSSDNDSECANKDRRVLTLALLTKSKTGELRVIGPMAASSALVGDAGELEQLRRRVSAGMGLTDDGDISFAAADKVNEGLYGVRVMGSGDSYTFFNVTVATETAGDDRDLATVRHVDIAHNIVPSEDRDHVFVSMPRMHVAWPHGTTVLHPKMIIAAASWRPEYNFTYEWYAVPYDGYCATMRLFEACLYHPSAPACLDPAGHRGCVVGTMTHDDLVGRVLMARCRGSDLRTCEPHVIHIKQKPMVSLGRAVPELRVESAAHIPSLYILVVKIDDSVAGWAYTELMAEGSSPRVVIDIHMPRPTSAQGGIAALREIENDDSAPSLGSNEGGGPGNSKRRAAVLGAAVWIALTLLILGGLGAYVAVNKKCLRDKRQWLRGSRKPTLETHAHTYTSLPVGGDLSLEQDAEDEDEDEEELLYERERRRSSSGSKKSSRSPSRRSSRRNSFGPTLSANALSRFDKTVKLAMAEVAGRLLANKTFPSQRY
What is the function of this protein?
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions.  Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions.  Implicated in basolateral spread in polarized cells.  In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system.  Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips (By similarity).
What are the official names of this protein?
Envelope glycoprotein E, gE.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein E family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass membrane protein. Host endosome membrane; Single-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein. The heterodimer gE/gI then redistributes to cell junctions to promote cell-cell spread later in the infection (By similarity).
Protein: AIM46_YEAS8
Sequence: MRLISKVLVKTNCLEVGMRRAPQWYSHYSTTAGNARVNKKGSKVVPVLTGLALASIFAKKWYDDSQIKKADATSVAVDASISAFPKKMGPPQWPFSTQYELIGKGVRCVSSITFKAYGLGIYVAAEDKHLVSEVLDSKFLSQAFIDTAAPPSPENSHQDNLRAALNDPAKAPILINNLLDSGIRLMSKNTPIKAGSFKLLMDGTKKSVLKNPDSQSQDKDRLEAGFQELHDCFRSVKGLVARDDDFFIELNKDCSMNLSYYARKKDEFVILGTVKEPLIGKLLFAHYLAAVDPPSPEARKEVIDALVSLS
What are the official names of this protein?
Altered inheritance of mitochondria protein 46, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM18/AIM46 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: KTHY_COXBU
Sequence: MEKNMGIERGRFISFEGIEGVGKTTALNWVREQLDAARIPYVVTREPGGTPIAEAIRDVLLSHSDEMMCPDTELLLMFAGRAQNIAHVVLPALRRGQWVLSDRFTDASFAYQGGGRGIPVKHIEELAGWVLGNLKPDLTLLLDAPVSVGLCRVKSRGAKDRIEAEGLEFFKRVRECYLALANQEPARFRVIHTDQDLSNVKNQIMKAIKPLLTASPLPGEKTEIEGL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SP5G_ACET2
Sequence: MEITDVRIRKIDSEGKMKAVVSVTFDNEFVVHDIKVIESQNGLFIAMPSRKAPDGEFRDIAHPINAETRSKIQTAILDKYESICAGSTETEGNN
What is the function of this protein?
Could be involved in septation.
What are the official names of this protein?
Putative septation protein SpoVG.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: PYRG_SERP5
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERYIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERILEGGEGHDVVLVEVGGTVGDIESLPFLEAIRQMAVEVGREHTLYMHLTLVPYLAAAGEVKTKPTQHSVKELLSIGIQPDVLICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLLKSQGLDDYICKRFSLNAPEANLAEWEQVIYEEANPGGEVTIGMVGKYVELPDAYKSVIEALKHGGLKNRLTVNIKLIDSQDVETRGVEVLKGLDAILIPGGFGYRGVEGKVMTARYARENNIPYLGICLGMQVALMEFARNVVGMENANSTEFVPDCKYPVVALITEWRDEDGNVEVRTEESDLGGTMRVGGQQCHLTDNSLVRQMYGEPTIVERHRHRYEVNNMLLKQIEAAGLLVAGRSADNKLVEIIELPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAAGEYQKRQVK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CUTC_ECOBW
Sequence: MALLEICCYSMECALTAQQNGADRVELCAAPKEGGLTPSLGVLKSVRQRVTIPVHPIIRPRGGDFCYSDGEFAAILEDVRTVRELGFPGLVTGVLDVDGNVDMPRMEKIMAAAGPLAVTFHRAFDMCANPLYTLNNLAELGIARVLTSGQKSDALQGLSKIMELIAHRDAPIIMAGAGVRAENLHHFLDAGVLEVHSSAGAWQASPMRYRNQGLSMSSDEHADEYSRYIVDGAAVAEMKGIIERHQAK
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_COXB2
Sequence: MAHKKAGGSTRNGRDSNPKMLGVKRFGGERVLAGNIIVRQRGTHYRPGENMGMGRDHTLYALIEGKVKFTRKGPKKRNFVSIEPLEESQP
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RPOC_VIBCH
Sequence: MKDLLNFLKAQHKTEEFDAIKIGLASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRDRMGHIELASPVAHIWFLKSLPSRIGLLMDMPLRDIERVLYFEMYVVTEPGMTDLERGQMLTEEEYLDRLEEWGDEFTAKMGAEAIKDLLASMDLPAEAEQMREELDTTNSETKRKKLTKRLKLVEAFVASGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELAAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYSKLETRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARTLMMSTNNILSPASGDPIIVPSQDVVLGLYYMTREKINAKGEGMYLTGPAEAEKAYRTKTAELHARVKVRITETIKHENGKLTTETKMIDTTVGRAMLWQIVPKGLPYSLVNQKLGKKQISNLLNEAYRKLGLKDTVIFADQIMYTGFAYAALSGVSVGIDDMVVPAAKYTEIAEAEEEVREIQEQFQSGLVTAGERYNKVIDIWASTNDRVAKAMMENLSSEQVINRQGEQEKQESFNSIYMMADSGARGSAAQIRQLAGMRGLMARPDGSIIETPITANFKEGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDVVVTEHDCGTLEGVVMTPHIEGGDVKVALTELALGRVVSEDILKPGTDEVLIPRNTLLDEKWCKVINDNSVDQIKVRSVVTCDSDFGCCAQCYGRDLARGHLVNQGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASTAAAENSIQAKNNGSVKLHNAKFVTNKDGKLVITSRASELTIIDEFGRTKEKHKLPYGSMLSKADGDAVAAGETVANWEAHTMPIITEVAGRVQFVDMIDGVTVSRQTDDLTGLSSSEVTEAAARPAAGKDMRPAIKLVDANGKDVLIPGTDMPAQYFLPGKAIVNLDDGAEVNVGDTLARIPQKSGGNKDITGGLPRVADLFEARKPKEPAILAEHSGTVSFGKETKGKRRLIITRDSGDTYEEMIPKHRQLNVFEGERIERGDVIADGPESPHDILRLRGIHAVTTYIANEVQEVYRLQGVKINDKHIETIVRQMLRKCTITFAGDSEFLPGETVEYSQVKIANRKLVEEGKEPARFERELLGITKASLATESFISAASFQETTRVLTEAAVSGKRDDLRGLKENVIVGRLIPAGTGFAYHQDRQAKRAQEQQGPSAEQATDNLAALLNAGFSSDDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: YHBQ_ECO24
Sequence: MTPWFLYLIRTADNKLYTGITTDVERRYQQHQSGKGAKALRGKGELTLAFSAPVGDRSLALRAEYRVKQLTKRQKERLVAESAGFAELLSSLQTPEIKSD
What are the official names of this protein?
UPF0213 protein YhbQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: NAPA_ECOHS
Sequence: MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQEAIKWDKAPCRFCGTGCGVLVGTQQGRVVACQGDPDAPVNRGLNCIKGYFLPKIMYGKDRLTQPLLRMKNGKYDKEGEFTPITWDQAFDVMEEKFKTALKEKGPESIGMFGSGQWTIWEGYAASKLFKAGFRSNNIDPNARHCMASAVVGFMRTFGMDEPMGCYDDIEQADAFVLWGANMAEMHPILWSRITNRRLSNQNVTVAVLSTYQHRSFELADNGIIFTPQSDLVILNYIANYIIQNNAINQDFFSKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFEDYKAFVAEYTLEKTAEMTGVPKDQLEQLAQLYADPNKKVISYWTMGFNQHTRGVWANNLVYNLHLLTGKISQPGCGPFSLTGQPSACGTAREVGTFAHRLPADMVVTNEKHRDICEKKWNIPSGTIPAKIGLHAVAQDRALKDGKLNVYWTMCTNNMQAGPNINEERMPGWRDPRNFIIVSDPYPTVSALAADLILPTAMWVEKEGAYGNAERRTQFWRQQVQAPGEAKSDLWQLVQFSRRFKTEEVWPEELLAKKPELRGKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHDLAPFDDYHKARGLRWPVVNGKETQWRYSEGNDPYVKAGEGYKFYGKPDGKAVIFALPFEPAAEAPDEEYDLWLSTGRVLEHWHTGSMTRRVPELHRAFPEAVLFIHPLDAKARDLRRGDKVKVVSRRGEVISIVETRGRNRPPQGLVYMPFFDAAQLVNKLTLDATDPLSKETDFKKCAVKLEKV
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: PURNU_STRCO
Sequence: MIGQRDTVNGAHFGFTDRWGGVSAVPYEELNLGGAVGDDPGAVTANRELAAKSLGVDPARVVWMNQVHGADVAVVDAPWGDRPVPRVDAVVTAERGLALAVLTADCVPVLLADPVSGVAAAAHAGRPGLVAGVVPAAVRAMAELGADPARIVARTGPAVCGRCYEVPEEMRAEVAAVEPAAYAETGWGTPALDVSAGVHAQLERLGVHDRAQSPVCTRESADHFSYRRDRTTGRLAGYVWLD
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine.  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate.  Also has adenosine deaminase activity.
What are the official names of this protein?
Purine nucleoside phosphorylase SCO2081, Adenosine deaminase SCO2081, S-methyl-5'-thioadenosine phosphorylase SCO2081.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
Protein: KRA46_HUMAN
Sequence: MVSSCCGSVCSDQGCGLETCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPSCCVSRCCRSQCCQSVCCQPTCCRPSCCISSCCRPSCCESSCCRPCCCRPCCCLRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 4-6, Keratin-associated protein 4-15, Keratin-associated protein 4.15, Keratin-associated protein 4.6, Ultrahigh sulfur keratin-associated protein 4.15.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 4 family.
Protein: CHB1_LYMDI
Sequence: MSAKIILVFCAQALFVQSALSQCTSRATVAADRGIIGGYGLGAPYGLAYGLEAPLGLGYGLGAPCGLAGPAIDITPTIGGGLPVSSASAIAPVGLVVASENVYEGILAAAGELPFVGTVGVEGVLPTAGAGAVHHSCGDGINAMASRDAAFAPGYAGAHGIGLGAYGLGVPALEVPALGYRAGWRGCGCGL
What is the function of this protein?
This protein is one of many from the eggshell of the gypsy moth.
What are the official names of this protein?
Chorion class B protein Ld10.
What is the protein family that this protein belongs to?
Belongs to the chorion protein family.
Protein: COBQ_VIBVU
Sequence: MEAKVTTLMVQGTTSDAGKSVLVAGLCRVLARKGVNVAPFKPQNMALNSAVTKEGGEIGRAQAVQAQACRIEPSVHMNPVLIKPNSDTGAQIILQGKALTNMDAYGFHNYKKVAMDTVMDSFARLKDEYQAIMIEGAGSPAEINLRQNDIANMGFAEEADVPVIIVADIDRGGVFAHLYGTLALLSPSEQARVKGFVINRFRGDIKLLESGLDWLEEKTGKPVIGVLPFLHGLNLEAEDAITSQQELSGEVKLKVVVPVLTRISNHTDFDVLRLHPQIDLRYVGKGERLEHADLIILPGSKSVRDDLRYLREQGWDKDILRHLRFGGKVLGICGGYQMLGESISDPFGVEGEPGESVGLGLLKTRTELTQDKCLINTKGQLSLNGKHVNVTGYEIHVGRSQVNEYQPITNDDGQLEGALSECGQIMGSYLHGFLDSEAVLELICEWVNGVRIKAQNHQQLKEQAIDRIADAIEEHLDLSQLGI
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: APT_LEUCK
Sequence: MTVDLYNYVATVENFPEPGVNFRDISPLMGDGVAYKQAVDAIADFAKDLNVDLIAGPESRGFIVGSPLAYALNIGFVPARKGGKLPRAAVSAAYSLEYGGENVLEIHQDAIKPGQRVLIVDDLLATGGTINATREIIEKLGGIVAGVAFIIELTDLHGREKIMQNGREVPFLTLMTY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POXJ_PENO1
Sequence: MVDNQGPLAKDVSLANPPSDSISELSWSPVANHLAMSSWDQTVRIYDVSQSGNGEGQALFNFPAPVLSCTFSPDGAKVLGGATDGSARLMDLVAGKEAQQVAAHDAPVRCVRFFGNPGVRDPIAVTGSWDQTVKYWDLRQDRPLATLQCQERVYAMDLCQNLLVVATAGRLVHVVQLSNADQIYKTVTSPLKHQTRTVTCIPDASGFAIGSTEGRTGFHYVDESKSSLNFTFRCHREMAASKNTQNVYAVNDVSFHPKYYTFSTAGADGTFAFWDKDAHHRLKSFPSVGAPITSTGFNHDGTIFAYAVSYDWSKGFRYNTPEHPTRVVCHPVDDVDCRPKNPVKR
What is the function of this protein?
WD40 repeat protein; part of the gene cluster that mediates the biosynthesis of oxaleimides, cytotoxic compounds containing an unusual disubstituted succinimide moiety (PubMed:28365998).  The first step of the pathway is provided by the HR-PKS poxF that serves in a new mode of collaborative biosynthesis with the PKS-NRPS poxE, by providing the olefin containing amino acid substrate via the synthesis of an ACP-bound dec-4-enoate (PubMed:28365998).  The cytochrome P450 monooxygenase poxM-catalyzed oxidation at the alpha-position creates the enzyme-bound 2-hydroxydec-4-enoyl-ACP thioester, which may be prone to spontaneous hydrolysis to yield 2-hydroxydec-4-enoic acid due to increased electrophilicity of the carbonyl (PubMed:28365998).  2-hydroxydec-4-enoic acid can then be further oxidized by poxM to yield the alpha-ketoacid 2-oxodec-4-enoicacid, which is reductively aminated by the aminotransferase poxL to yield (S,E)-2-aminodec-4-enoic acid (PubMed:28365998).  The Hybrid PKS-NRPS synthetase poxE then performs condensation between the octaketide product of its PKS modules and the amino group of (S,E)-2-aminodec-4-enoic acid which is activated and incorporated by the adenylation domain (PubMed:28365998).  The resulting aminoacyl product can be cyclized by the Diels-Alderase PoxQ and reductively released by the reductive (R) domain of poxE to yield an aldehyde intermediate (PubMed:28365998) (Probable).  The released aldehyde is then substrate for a Knoevenagel condensation by the hydrolyase poxO followed by an oxidation at the 5-position of the pyrrolidone ring (PubMed:28365998).  The presence of the olefin from the amino acid building block allows for migration of the substituted allyl group to occur (PubMed:28365998).  This allylic transposition reaction takes place in a conjugate addition, semipinacol-like fashion to yield a succinimide intermediate (PubMed:28365998).  Iterative two-electron oxidations of the C7 methyl of the succinimide intermediate to the carboxylic acid can be catalyzed by one of two remaining cytochrome P450 monooxygenasess poxC or poxD to yield oxaleimide A (PubMed:28365998).  Subsequent oxidation yields the maleimide scaffold oxaleimide I (PubMed:28365998).  Both oxaleimide A and oxaleimide I can undergo oxidative modifications in the decalin ring to yield the series of products oxaleimides B to H (PubMed:28365998).
What are the official names of this protein?
WD40 repeat protein poxJ, Oxaleimides biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the WD repeat rae1 family.
Protein: BTS5_THECC
Sequence: MEAVKDVLCMNNGVGENSYVKAEALTIKVMAITKPIVPKAVQSLFTETDHSIPLQVVNVADLGCAVGPQPLEFMSTVIESILKKCGEMGREMPEIQFFLNDLVGNDFNTLFKGLSVVQEKYKKVSWFAMGAPGSFHGRLFPRNSMHLVYSCYSVHWLSEAPKITNEAGLPLNKGKIYMSKTSPPAVTKAYLSQFQEDFSSLLKFRSQELAPNGRVVLIFNGRQTADPTNKDTCYTWDLLAEALSYLVSQGLVDEGKLDSFNVPYYNPSQEEIKYLVDKEGSLTIEFIDTIELEIGGPNGYWSSPESRIRGHRCFTEPLLSHQFGERLMDKLYDKATQILVEDYKHGKEATKNIGIAVVLKKKKL
What is the function of this protein?
Involved in the biosynthesis of theobromine.
What are the official names of this protein?
Probable 7-methylxanthine methyltransferase 5, Theobromine synthase TCM_042587/TCM_042590.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
Protein: KINUA_ARATH
Sequence: MSTTSGTGGVSYRNGTQRSSLRTQSSASTSSGGQKASVKSKSVLRKSSPAALGGGSSKSGGGGDAGVPGRVRVAVRLRPRNGEELIADADFADCVELQPELKRLKLRKNNWDTDTFEFDEVLTEYASQKRVYEVVAKPVVEGVLDGYNGTIMAYGQTGTGKTYTLGQLGEEDVADRGIMVRAMEDILAEVSLETDSISVSYLQLYMETVQDLLDPSNDNIAIVEDPKNGDVSLPGATLVEIRDQQSFLELLQLGEAHRFAANTKLNTESSRSHAILMVNVRRSMKTRDGLSSESNGNSHMTKSLKPPVVRKGKLVVVDLAGSERINKSGSEGHTLEEAKSINLSLSALGKCINALAENSSHVPFRDSKLTRLLRDSFGGTARTSLVITIGPSPRHRGETTSTIMFGQRAMKVENMVKIKEEFDYKSLSRRLEVQLDNLIEENERQQKAFVDEIERITVEAHNQISEAEKRYANALEDEKLRYQNDYMESIKKLEENWSKNQKKLAAERLALGEKNGLDITSNGNRSIAPALEEVSELKKLLQKEAQSKMAAEEEVNRLKHQLNEFKKVEASGNSEIMRLHKMLENETQQKEKLEGEIATLHSQLLQLSLTADETRRNLEQHGSEKTSGARDSLMSQLRLPQIQDPGNAEKPPVARLFEQVGLQKILSLLEAEDADVRIHAVKVVANLAAEEANQQQIVEAGGLTSLLMLLKNTEDETIHRVAAGAIANLAMNETNQELIMDQGGIGLLSSTAANAEDPQTLRMVAGAIANLCGNDKLQTKLRSEGGIAALLGMVRCGHPDVLAQVARGIANFAKCESRASTQGTKRGKSLLIEDGALSWIVQNAKTETAAIRRHIELALCHLAQHEGNAKEMVKEGAMWELVRISRDCSREDIRSLAHRTLTSSPTFLTELRRLRVDIR
What are the official names of this protein?
Kinesin-like protein KIN-UA, AtKINUa, Protein ARMADILLO REPEAT KINESIN3, Protein ARMADILLO REPEAT-CONTAINING KINESIN 3, kinesin-like protein PAK.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Ungrouped subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules during interphase. Accumulated at the preprophase band in a cell cycle- dependent manner with a high expression during prophase that decreases after nuclear envelope breakdown.