PharMolix/UniProtQA huggingface dataset:
Protein: CPFC_CORGL
Sequence: MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTHGRGIPPERLDEVAVHYHHFGGISPINALNREIIANVEKELASRDHKLPVYFGNRNWKPFDNEAAEQMADDGVKNALVLATSAWGGYSGCRQYQEDIQGMIKHLESQGQSITFTKLRQFYDHPRFVSTMAQLVQDSYAKLPDELRDEARLVFTAHSIPLTADNAAGTPEDGSLYSTQVKEASALIAEAVGVSDFDVVWQSRSGSPHTPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVATVGPTDEFAALVVDLIEEAELKRVIERLGKLPARGSSVNGAPCGDGCCGTAKHKTARVNPNARSAAPAAN
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
What are the official names of this protein?
Coproporphyrin III ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPN3_KLULA
Sequence: MSRVGVLVLGPAGAGKSTFCNAIISHMQSIGRRAHIVNLDPAAEATKYEFTIDIRDLISLEDVMEEFGLGPNGSLIYCFEYLLNNLDWLDEEIGDYNDEYLIFDCPGQIELYTHIPVLPTIVRHLQNQLNFNLCATYLLEAPFVIDTSKFFSGALSAMSAMILLELPHINILSKLDLVKDSHNKKALKKFLNPDPLLLTDKVNEETNPKFHKLNEAIANLVDDFGMVQFLPLEAKNPESVSTILSYIDDVTQWAEAQEPKEPNDQIEIDDM
What is the function of this protein?
Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII).  May act at an RNAP assembly step prior to nuclear import.
What are the official names of this protein?
GPN-loop GTPase 3.
What is the protein family that this protein belongs to?
Belongs to the GPN-loop GTPase family.
Protein: CH60_PSEE4
Sequence: MAAKDVKFGDSARKKMLVGVNVLADAVKATLGPKGRNVVLAKSFGAPTITKDGVSVAKEIELKDAFENMGAQLVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKATAAIVAELKNLSKPCADSKAIAQVGTISANSDNSIGEIIAEAMEKVGKEGVITVEEGSGLENELSVVEGMQFDRGYLSPYFVNKPDTMVAELEGPLLLLVDKKISNIRELLPVLEAVAKAGRPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGQVISEEIGLSLETATLEHLGNAKRVILSKENTTIIDGAGADGDIEARVKQIRAQIEETSSDYDREKLQERLAKLAGGVAVIKVGAGTEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALVRALAAIADLKGDNEEQNVGIALLRRAVEAPLRQITANAGDEPSVVADKVKQGSGNFGYNAATGEYGDMIEMGILDPAKVTRSALQAAASIGGLMITTEAMVADLPEDKPAAGMPDMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_RHILO
Sequence: MPIRQLSETMINQIAAGEVIERPASVVKELVENALDAGASRVEVVTAGGGLNLIRVTDDGSGIPEPELALAIARHCTSKLAEDINDIRSLGFRGEALPSIGSVSRLSIRSRTALGDSAAEIGIEGGRVLPVRPAAANRGTTVEVRDLFFATPARLKFMKGERAESSATSDVVKRIAIAFPAVRFTLAGSDRSTLELPATDDSPEGSLRRVAQVMGAEFPDNSIAIDAMREGVHLTGHVSIPSFSRANALQQYAYVNGRPVRDKLIAGAIRGAFADVLPRDRHAVTVLFLTLDPAIVDVNVHPAKADVRFRDPGLVRGLIVGAIRQALADAGIRSATTGAAGMMAAFRPGAASYNHGGPANGHRSYEAAYRASGSAGFDPARSPQRPLDMQFGDFERAGARHGGFSEPGQAAFDTGPLVSADARVGQNETTETLLGTVLGAARAQVHENYIVAQTRDSLVIVDQHAAHERLVYEALKNALHSRPVPSQMLLLPEIIDLPEEDAERLAMHSETLARFGLGIERFGPGAVAVRETPSMLGETNVQQLVRDLADEIADNDTVETLKERLDKIAATMACHGSVRSGRLLKAEEMNALLRQMEATPGSGTCNHGRPTYIELKLADIERLFGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: DOHH2_ORYSJ
Sequence: MEGFLCDRLLDAAQPIAERFRALFSLRNLRGDAPRRALLQAARDSSNLLAHEAAFALGQMQDAEAIPALEAVLKDLSLHPIVRHEAAEALGAIGLEKSISLLEESLAVDPAVEVQETCELAIRRIEEQKNTSGVESATVSPFLSVDPALPAKQGLPVEQLRELLLNEQESMYERYAALFALRNDSGDAAVSAIVAALGVKSALLRHEVAYVLGQLQNKAASDALSTVLKNVDEHPMVRHEAAEALGSIADQESIALLEEFAKDPEPIVSQSCEVALSMLEYERSGKAFEFLFPQTPQVQQES
What is the function of this protein?
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
What are the official names of this protein?
Deoxyhypusine hydroxylase-B, DOHH-B, Deoxyhypusine dioxygenase-B, Deoxyhypusine monooxygenase-B.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine hydroxylase family.
Protein: MURG_XYLFT
Sequence: MVQSAVTHFRPVMILAGGTGGHIFPGLAVAGVLRARGVPVVWLGAAGKMETHLVPKHGIEIQTIAVSGVRGHGMLALLGAPVRVLPAIFAAMRVLRRYRPRVVVSFGGFAAGPGGIAARLMGLPLIVHEQNRAPGMTNRVLARVARRVLSGFPGSFVAEEVVGNPVRKDIAALPAPGVRFAGRSGPVRLLVLGGSQGARVMNNALPVVLRVLSDSDVAVEVRHQCGEALRAETEGAYAYAGVAARVEPFISDMAAAYSWADLVVCRAGASTLAELCAAGVGSVLIPFPAAVDDHQRRNAEYLVAAGAALLLQQQDRAFYVYLESVLRDLLSNPMRRLAMAEAARGLAKSDAAECIAEIILKESI
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TROL_ORYSI
Sequence: MAATTTILSSAAPTPLTAPPRARARAPAARRRRLRARDILGAALGLANGGASAALAAPLSYEETLRLSTDSGGGGGGGGEFALPDLGLGGVLDFVAQNPLVAAAGVAAVALPLVLAQVLGGASKPYGVVSAAAAYRALVEEPGAQLVDIRPPGDARQSGAPDLREAKKKAAAVPYDGEDKNGFLKKLSLRFKDPENTTLVILDKFDGNSELVAELVTANGYKAAFAVKDGAEGRRGWLSSSLPWTAPKKGFSLSDLIGDGTDGLPVTLGLAAATGLGILAYTEIETVLQFLGSAAIVQLVASKLIYAEDRKRTLKQIDDFFNKKVAPKELVDEIKEISQALLPSTGTKSQPAITEAAPATAEAAPAAATATAAPPAAPVEETSTEAAPAEPTPLSPYTNYPDLKPPSSPSPLAPAEATKNESESESAATESAPAVNSAPVAEAAPEAAPPAAPRPLSPYPNYPDLKPPSSPSPSAP
What is the function of this protein?
Rhodanese domain-containing protein required for anchoring ferredoxin--NADP reductase to the thylakoid membranes and sustaining efficient linear electron flow (LEF).
What are the official names of this protein?
Protein THYLAKOID RHODANESE-LIKE, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Mainly localized to the non-appressed regions of the thylakoid membrane.
Protein: SYQ_BORA1
Sequence: MTQTTAPHAASNYLRNIIEDDLAANRFQGKRWAGKPGPASMQASGLPDPARIRTRFPPEPNGYLHIGHAKSICVNFGIAKEFGGVCHLRFDDTNPEKEDQEYVDAIIEAVRWLGFDWNTDGNNNLYFASDYFEFMYEFAEALIEAGHAFVDEQSADDIRAQRGTLTEPGRNSPFRDRPAAESLTRLREMRDGKHPDGSLVLRARIDMASPNINLRDPVMYRVRHAAHHRTGDKWCIYPMYSWAHPVEDALEGITHSICTLEFEDQRPFYDWILARLADLGKLARPLPRQYEFSRLNMSYIVTSKRKLLQLVREGYVDGWDDPRMPTLFGLRRRGYTASAIRLFCDRTAVSKSDSRIDYSLLEQAVRDDLDPGTTRSVAVLDPLKLVITNYPKDQTEVCKAPRNPHDPEAGQREFPFSRELWIERDDFREEAPKKYFRLFPGNLVRLKYGYVVRCTGFTKDEAGNITEVQAEYLPDTKSGTPGADSVKVKGNITWVSAAHAVPAEVRLYDRLFADPHPDGGDKDFLACLNPNSIQTVQAWLEPGTRAEPGATWQFERLGYFTVDSKDSSPEAPVLNRIVTLKDSWAA
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNAI3_MOUSE
Sequence: MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGESARADDARQLFVLAGSAEEGVMTSELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQTNYIPTQQDVLRTRVKTTGIVETHFTFKELYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEVYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
What is the function of this protein?
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades.  The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state.  Signaling by an activated GPCR promotes GDP release and GTP binding.  The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal.  Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins.  Signaling is mediated via effector proteins, such as adenylate cyclase.  Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels.  Stimulates the activity of receptor-regulated K(+) channels.  The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane.  May play a role in cell division.
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-3, G(i) alpha-3.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
Protein: GLPK_SALPC
Sequence: MTEKKYIVALDQGTTSSRAVVMDHDANIVSVSQREFEQIYPKPGWVEHDPMEIWASQSSTLVEVLAKADISSDQIAAIGITNQRETAIVWERETGKPIYNAIVWQCRRTADICEQLKRDGLEDYIRDNTGLVVDPYFSGTKVKWILDHVEGSRERAKRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHDLDWDDKMLDVLDIPRAMLPQVRKSSEVYGQTNIGGKGGTRIPIAGIAGDQQAALFGQLCVKEGMAKNTYGTGCFMLMNTGEKAVKSENGLLTTIACGPSGEVNYALEGAVFMAGASIQWLRDEMKLISDAFDSEYFATKVKDTNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNSNHIIRATLESIAYQTRDVLEAMQADSGIRLHALRVDGGAVANNFLMQFQSDILGTRVERPEVREVTALGAAYLAGLAVGYWQNLDELQEKAVIEREFRPGIETTERNYRYSGWKKAVKRAMAWEEHDK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: LEPA_MYCTO
Sequence: MRTPCSQHRRDRPSAIGSQLPDADTLDTRQPPLQEIPISSFADKTFTAPAQIRNFCIIAHIDHGKSTLADRMLQLTGVVDERSMRAQYLDRMDIERERGITIKAQNVRLPWRVDKTDYVLHLIDTPGHVDFTYEVSRALEACEGAVLLVDAAQGIEAQTLANLYLALDRDLHIIPVLNKIDLPAADPDRYAAEMAHIIGCEPAEVLRVSGKTGEGVSDLLDEVVRQVPPPQGDAEAPTRAMIFDSVYDIYRGVVTYVRVVDGKISPRERIMMMSTGATHELLEVGIVSPEPKPCEGLGVGEVGYLITGVKDVRQSKVGDTVTSLSRARGAAAEALTGYREPKPMVYSGLYPVDGSDYPNLRDALDKLQLNDAALTYEPETSVALGFGFRCGFLGLLHMEITRERLEREFGLDLISTSPNVVYRVHKDDGTEIRVTNPSDWPEGKIRTVYEPVVKTTIIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYTMPLGEIIFDFFDALKSRTRGYASLDYEEAGEQEAALVKVDILLQGEAVDAFSAIVHKDTAYAYGNKMTTKLKELIPRQQFEVPVQAAIGSKIIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSTDAAGDKGKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LEPA_CLOAB
Sequence: MQSERQKHIRNFCIVAHIDHGKSTLADRLLEHTGTLTHREMEEQVLDNMEIERERGITIKSQAARLIYKRPEDGQEYILNLIDTPGHVDFNYEVSRSLAACEGAVLVVDATQGIQAQTLANCYMAVDHGLEVVPVINKIDLPSARPDEIKNEIEDVIGIESSDAPLISAKTGLNIEDVLEAVVQKVPAPSGDEKGPLKALIFDSYYDSYKGVVCHIRIKDGTVKAGTRIKLMAANKEYEVIEVGVFVPNYLKVEELKAGDVGYITASIKNVRDARVGDTITEVNNPAKEPLLGYRPAISMVYSGIYPIDSSKYEELKEALEKLQVNDAALNFEPETSIALGFGFRCGFLGLLHMEIMQERIEKEFNLDVIMTAPSVIYKVKKTDGTLIEITNPTNLPEPTEIDYMEEPVVKAQIITPSDFVGAVMELCQNKRGTFIDMEYIETTRVMLNYRVPLNEIIYDFFDSLKSRTKGYASFDYELDGYMRTELVKLDIILNSEVVDALSMIVPKDRAYAKGRTMAEKLKEIIPRQLFEIPIQAAVGSKIIARETVKALRKDVLAKCYGGDISRKRKLLEKQKEGKKRMRQVGSVEVPQEAFMSILKND
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y561_CUPTR
Sequence: MDNRLLEILVCPLCKGKLEYDRAAQELICHADKLAYPIRDGIPVMLADEARQSVPGRVIEPDAPAGN
What are the official names of this protein?
UPF0434 protein RALTA_A0561.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: BGALB_EMENI
Sequence: MATAFWLLLFLLGSLHVLTAAQNSSQSEWPIHDNGLSKVVQWDHYSFYINGQRIFLFSGEFHYWRIPVPALWRDILEKIKAIGFTGFAFYSSWAYHAPNNQTVDFSTGARDITPIYDLAKELGMYIIVRPGPYVNAEASAGGFPLWLTTGAYGSTRNDDPRYTAAWEPYFAEVSEITSKYQVTDGHYTLCYQIENEYGQQWIGDPRDRNPNQTAIAYMELLQASARENGITVPLTGNDPNMNTKSWGSDWSDAGGNLDTVGLDSYPSCWSCDVSVCTGTNGEYVPYKVLDYYDYFQEVQPTMPFFMPEFQGGSYNPWDGPEGGCTEDTGADFANLFYRWNIGQRVSAMSLYMMFGGTNWGGIAAPVTASSYDYSAPISEDRSIGSKYYETKLLALFTRCAKDLTMTDRLGNGTQYTDNEAVIASELRNPDTNAAFYVTTHLDTTVGTDESFKLHVNTSKGALTIPRHGGTIRLNGHHSKIIVTDFNFGSETLLYSTAEVLTYAVFDRKPTLVLWVPTGESGEFAIKGAKSGSVAKCSGCSNIKFHRDSGSLTVAFTQGEGISVLQLDNGVRVVLLDRQKAYTFWAPALTDNPLVPEGESVLVSGPYLVRTARLARSTLTLRGDSKGETLEIFAPRKIKKVTWNGKAVEATRTSYGSLKAILAKPPSVELPTLNGWKYSDSLPERFPTYDDSGAAWVEIDANHMTTPNPNKPATLPVLYADEYGFHNGVRLWRGYFNSSASGVYLNIQGGAAFGWSAWLNGHFLGSHLGSASIQQANGTLDFPANTLNTEGTPNVLLVVHDDTGHDQTTGVLNPRGILEARLLSEASDNNDDDSPGFTHWRVAGTAGGESDLDPVRGVYNEDGLYAERVGWHLPGFDDSKWATVNGTSLSFTGATVRFFRTVIPPLSIPENTDVSISFVFSTPNVNNTSAGNTSAFRAQLFVNGYQYGRYNPYVGNQVVYPVPPGILDYNGENTIGVAVWAQTEAGARLNLDWRVNYVLGSSLDAGRLDLSFVAIAYVYIFECLQL
What is the function of this protein?
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
What are the official names of this protein?
Probable beta-galactosidase B, Lactase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL6_SALG2
Sequence: MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNALTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVVNLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: Y754_PSYIN
Sequence: MTIWIDADACPVPVREMVLRAGQRTATALVFVANSPLPVPRRALVKTVQVAQGFDVADNYISQHAVINDLVITQDIPLAAEIVEKGITALNPRGELYTEANIRQRLAMRNLSEELRSMGQISGGPNKFGDKEKQNFANALDRWLQKAKKTT
What are the official names of this protein?
UPF0178 protein Ping_0754.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: RL2_SHEHH
Sequence: MAVIKCKPTSPGRRHLVKVVNSDLHKGKPFAGLLAKKSKSGGRNNTGRITVRHIGGGHKQHYRLIDFKRNKDGIPAKVERLEYDPNRTANIALVLYADGERRYILAAKGMQAGDKIQSGIDAEIKSGNAMPLRNIPVGSVVHAVEMKPGKGAQIARSAGAYVQVIARDGAYATLRLRSGEMRKVPVDCRATLGEVGNAEHMLRQLGKAGAKRWRGVRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGQPTKGYKTRSNKRTDKYIVRRRNKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: UBTD1_RAT
Sequence: MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPTPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHSQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD
What is the function of this protein?
May be involved in the regulation of cellular senescence through a positive feedback loop with TP53.  Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.
What are the official names of this protein?
Ubiquitin domain-containing protein 1.
Protein: VIF_HV1MA
Sequence: MENRWQVMIVWQVDRMRIRTWHSLVKHHMYVSKKAKNWFYRHHYESRHPKVSSEVHIPLGDARLVVRTYWGLQTGEKDWHLGHGVSIEWRQKRYSTQLDPDLADQLIHLYYFDCFSESAIRQAILGHIVSPRCDYQAGHNKVGSLQYLALTALIAPKKTRPPLPSVRKLTEDRWNKPQQTKGHRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: QUEF_ECO24
Sequence: MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKVSVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATSGEKVVEETLVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y253_LEGPL
Sequence: MTIMITTGNSFEGKVIKQYLGIVRGIVVRSPTISQGLMGGLKSIVGGKIGAYSQMCEHAREEAFQLMIEHAQALNANGIIAMRYDTGEIGQAGTEVLCYGTAVII
What are the official names of this protein?
UPF0145 protein lpl0253.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: PDXY_PHOLL
Sequence: MKNILSIQSHVVFGHAGNSAAEFPMRRMGVNVWPLNTVQFSNHTQYAQWKGCVMPANHLTEIVQGIEEIEQLKSCHAVLSGYIGSAEQGGHIIDIVKRVKAVNPDAWYFCDPVMGHPEKGCIVVPGVAEFLCKDALPVSDIIAPNLLELETLSMQKVTNVEQAVMAARTLCDKGPDIVLVKHLSRAGYRTDRFEMLLVTKEHSWHVSRPLVDFGERQPVGVGDLTSGLLLVNLLKGESLQTALEHVAAAVYEVMVTTKEMGEYELQIVAAQDRMVAPNHKFWAIQLD
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.
Protein: RECA_CLOPE
Sequence: MANIDKDKLKAIEMAMGQIEKQFGKGSVMKLGEQGAPQMDAVSTGCLDLDIALGIGGVPKGRIIEIYGPESSGKTTVALHVVAEAQKLGGAAAYIDAEHALDPVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTGTINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEFDIMYNEGISKEGNIVDVGVKENIVQKSGAWFSYGDIRLGQGRENAKQYLKENPAVALDIENQIREKYSLPLAKAVESTSVEENTEESVES
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_RUEPO
Sequence: MEWKITDGLTDYDAAVAFMEARAAAIAAGEAEECIWLLEHPPLYTAGTSARPADLTDPDRFPVYESKRGGQYTYHGPGQRVVYVMLDVGKRGHDVRRFVEQLEEWVIAALAEFNIRGEIRPGRVGVWVRREDKPLTLGGQPAEDKIAAIGIRLRKWVSFHGISINVEPDLSHFSGIVPCGITEYGVTSLVDLGLPVTMGDVDVALRQSFERVFGAD
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_MYCA1
Sequence: MTRHLLAAGDLSRDDATAILDDADRFAQALVGREIKKLPTLRGRTVVTMFYENSTRTRVSFEVAGKWMSADVINVSAAGSSVGKGESLRDTALTLRAAGADALIIRHPASGAAHLLAEWTCGNGDSSDAGPSVINAGDGTHEHPTQALLDALTIRQRLGGIEGRRVVIVGDVLHSRVARSNVMLLSTLGAEVVLVAPPTLLPVGVEGWPVTVSNDFDAELPAADAVLMLRVQAERMNGGFFPSVREYSSLYGLSDRRQAMLPGHAVVLHPGPMLRGMEIASSVADSSQSAVLQQVSNGVHVRMAVLFHVLVGAEEIAA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.