PharMolix/UniProtQA huggingface dataset:
Protein: RNH1_RAT
Sequence: MRWLLPLFRTVTLAVVRVRRGVCGLGMFYAVRRGRRTGVFLSWSECKAQVDRFPAARFKKFATEDEAWAFVRSSSSPDGSKGQESAHVQKLQVKTSKRPREPLGEEEEPPEPGAKHTRQDTEPAALVSKDAFSYMGESVVVYTDGCCSSNGRKRARAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAITQAKAQNISKLVLYTDSMFTINGITNWVQGWKKNGWRTSTGKDVINKEDFMELDELTQGMDIQWMHIPGHSGFVGNEEADRLAREGAKQSEG
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.  Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II.
What are the official names of this protein?
Ribonuclease H1, RNase H1.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_DANRE
Sequence: MAKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVRKSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAIRRQLTKHEENLMTKKMQRKSRLYSIRKFAVKA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity).  Plays an essential role in early embryonic development (PubMed:12006978).  May act as a haploinsufficient tumor suppressor (PubMed:15138505).
What are the official names of this protein?
60S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMYB_MAIZE
Sequence: MAGNALANYVQVYVMLPLDVITVDNTFEKEDETRAQLKKLTEAGADGVMIDVWWGLVEGKEPGVYDWSAYRQVFKLVQEAGLKLQAIMSCHQCGGNVGDVVNIPIPQWVRDVGKSNPDIFYTNRSGLTNIEYLTLGVDDQPLFHGRTAIQLYADYMKSFRENMADFLDAGVVVDIEVGLGPAGEMRYPSYPQSQGWVFPGVGEFICYDKYLQADFKAAAEEAGHPEWDLLDDAGTYNDTPEKTQFFADNGTYQTDKGKFFLTWYSNKLIKHGDKILDEANKVFLGCKVQLAIKVSGIHWWYNVPNHAAELTAGYYNLDDRDGYRTIAHMLTRHRASMNFTCAEMRDSEQSSEAKSAPEELVQQVLSAGWREGLNLACENALNRYDATAYNTILRNARPQGINKNGPPEHKLHGFTYLRVSDELFQEQNYTTFKTFVRRMHANLDYNPNVDPVAPLERSKAEIPIEEILEVAQPKLEPFPFDKDTDLPV
What are the official names of this protein?
Beta-amylase, 1,4-alpha-D-glucan maltohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 14 family.
Protein: RL7_BIFLD
Sequence: MAKYTNDELLEAFGEMTLVELSEFVKAFEEKFDVEAAAPVAAVAAVAGAAAPAEEEKDEFDVILSAVGDKKIQVIKAVRAITNLGLAEAKALVDGAPKAVLEKAKKEDAEKAKAQLEEAGASVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: IL11_MACFA
Sequence: MNCVCRLVLVVLSLWPDTAVAPGPPPGSPRASPDPRAELDSTVLLTRSLLEDTRQLTIQLKDKFPADGDHNLDSLPTLAMSAGALGALQLPSVLTRLRADLLSYLRHVQWLRRAMGSSLKTLEPELGTLQTRLDRLLRRLQLLMSRLALPQLPPDPPAPPLAPPSSTWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL
What is the function of this protein?
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.  Also promotes the proliferation of hepatocytes in response to liver damage.  Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation.  Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.  The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.
What are the official names of this protein?
Interleukin-11, IL-11.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NDA8A_ARATH
Sequence: MEANAAVDGTGNPIPTSAVLTASAKHIGIRCMPENMAFLKCKKNDPNPEKCLEKGRDVTRCVLGLLKDLHQRCPKEMDAYVGCMYYYTNEFELCRKEQEAFEKVCPLK
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-A.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA8 subunit family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion intermembrane space.
Protein: CCA_ACTP7
Sequence: MQIYLVGGAVRDQLLNLPVKDRDYLVVGATPEQLLAQGYQQVGNDFPVFLHPKTKEEYALARQERKNGVGYNGFLCDFSPDVTLEQDLIRRDLTINAIAQDASGQIFDPYGGKQDLANRLLRHISPAFSEDPLRVLRVARFAARFHSLGFKIAPETVKLMQEMTACGELAHLTAERVWLETQKAFATDNPQIYFEVLREIGALAVLFPEFDRLFGVPQPEQHHPEIDSGVHTLLVIEQAKRLAKNAENPTALLWAALCHDLGKGLTEKDILPHHYGHEVKGVKPARELSNRLKVSTDVKDFAILVTEYHTHCHKMAELRPETVLKVFNALDIWRKPQRFCDFLLACEADARGRLGFENREYPQAELAKWYFKVAAQVDVQAVIQDGFEKKAIREELNKRRITAIKIIKPNV
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: DEXH7_ARATH
Sequence: MAPKKKPQKQSNKAASSSSSSKSNYQKPSSGPKLQISAENEDRLRRLLLNSGRSGPSIPAPISNSLSKAQKTKKLNNVYEKLSCEGFVDDQIELALSSLRDGATFEAALDWLCLNLPSHELPVKFSTGASRFPSTGGSVGVISTSRDDWNDSTDSSVRVEEEEPAVFVRVKGKQDEEDTLSSDKSSQADWIRQYMMRQEEEELECWEDEVDGIDPRNKVSGPRPFDVIAKEYYSARSDAIKAKEKRDKRGQEQAGLAIRKLKQEISDLGLSEAMLESEFQREHAFESATEQESTCPISDNLHESVDADDVSVQMLDNLTLNTNPAESYESEEIQTKALPSSSSGQDFVASDEDSEDVELGDTFFEEIPPSEISPHELLELQKEEKMRELRSEKNLGKLDGIWKKGEAQKIPKAFLHQLCQRSGWEAPKFNKETGEGRNFSYTVSILRKASGRGKNRQAGGLVTLQLPPKDENFESIEDAQNKVAAFALHKLFSDLPVHFAITEPYASLVLIWKQEELLCTTIQSTEEDRRANFVDKLLEEDSFSLTTSSSSFENSLPLVDSYVKDKDDLGVVKSNNRAKRDSYIEAECLSLQRKQENKKRTQKYKDMLKTRTALPISEVKNGILQHLKEKDVLVVCGETGSGKTTQVPQFILDDMIDSGHGGYCNIICTQPRRIAAISVAQRVADERCESSPGLDDSLVGYQVRLESARSDKTRLLFCTTGILLRKLAGDRTLNDVTHIIVDEVHERSLLGDFLLIILKSLIEKQSCDNTSRKLKVILMSATVDADLFSRYFGHCPVITAQGRTHPVTTHFLEEIYESINYLLAPDSPAALRSDTSIKDKLGSVNDRRGKKNLVLAGWGDDYLLSEDCLNPFYVSSNYNSYSDQTQQNLKRLNEDRIDYELLEELICHIDDTCEEGAILIFLPGVAEIYMLLDMLAASYRFRGPAADWLLPLHSSIASSEQRKVFLRPPKGLRKVIAATNIAETSITIDDVVYVIDSGKHKENRYNPQKKLSSMVEDWISQANARQRTGRAGRVKPGICFSLYTRYRFEKLMRPYQVPEMLRMPLVELCLQIKLLGLGHIKPFLSRALEPPSEGAMTSAISLLHEVGAVEGDEELTPLGHHLAKLPVDVLIGKMLLYGGIFGCLSPILSIAAFLSYKSPFIYPKDEKQNVDRVKLALLSDNGVSSSDLNNNDRQSDHLLMMVAYDKWVKILQERGMKAAQRFCESKFLSSSVMRMIRDMRVQFGTLLADIGLINLPKTGEFSGRKKENLDVWFSDPTQPFNMYSQQPEVVKAILCAGLYPNIAANDKGITETTFNSLTKQGNQTKSYSAWYDGRREVHIHPSSINSNFKAFQNPFLVFLEKVETNKVYLRDTTIVSPFSILLFGGSINVHHQSGSVTIDGWLKVAAPAQTAVLFKELRLTLHSILKDLIRKPEKSGIVHNEVVKSMVHLLIEEGKPQHK
What are the official names of this protein?
DExH-box ATP-dependent RNA helicase DExH7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the DExH box helicase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KCNT2_RAT
Sequence: MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLEKPSQGNDWSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRVPFILEIINAVPFIISIFWPTLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDNAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQCVCLCCREGQQSPEQWQKTYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLVGVRREDNKNILLNPGPRYIMNASDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAIDLQDTSCRAASGPTLALPSEGGKELRRPSIAPVLEVADTSSIQTCDLLSDQSEDETTPDEETSSNLEYAKGYPPYSPYIGSSPTFCHLLQEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISITRLLLGLDTIPGSGFLCSMKITEDDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESQISISVEEWEDTKDVKDPGHHRSIHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRLELNDVVYLIRPDPLSYLPNSEPSRKNSICNAAVQDSREETQL
What is the function of this protein?
Outward rectifying potassium channel.  Produces rapidly activating outward rectifier K(+) currents.  Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:29069600).  Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:17699666).  Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (By similarity).
What are the official names of this protein?
Potassium channel subfamily T member 2, Sequence like an intermediate conductance potassium channel subunit, Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TY3H_MOUSE
Sequence: MPTPSASSPQPKGFRRAVSEQDTKQAEAVTSPRFIGRRQSLIEDARKEREAAAAAAAAAVASAEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRALKVFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQGEPIPHVEYTKEEIATWKEVYATLKGLYATHACREHLEAFQLLERYCGYREDSIPQLEDVSHFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIRRSLEGVQDELHTLTQALSAIS
What is the function of this protein?
Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline.  Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity).  In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity).  Positively regulates the regression of retinal hyaloid vessels during postnatal development(PubMed:30936473).
What are the official names of this protein?
Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Cell projection, axon. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=When phosphorylated at Ser-19 shows a nuclear distribution and when phsphorylated at Ser-31 as well at Ser-40 shows a cytosolic distribution (By similarity). Expressed in dopaminergic axons and axon terminals (PubMed:17296554).
Protein: Y965_HALH5
Sequence: MEALLKWSAAVLAAAVSFLYGEWTILLSILLTLVVIDYGTGLVAAGVTGNINSRVGLIGITRKVFIFVMVAIAHMIDTVLLEVGIETEALIFMAAVVFYIVNELISIFENAGRMGLPVPKQLKQAISILKGDESK
What are the official names of this protein?
Uncharacterized protein BH0965.
What is the protein family that this protein belongs to?
Belongs to the bacteriophage holin family. Cp-1 holin subfamily.
Protein: TT39B_MACFA
Sequence: MLVSSHLERLLVFVFEFIFIEIGFPPCTPRPVSTSSKGVTIESSHSDMATSSLHFASCDTQQAPRQRGASTVNSSSSTKVDLKSGLEECAVALNLFLSNKFTDALELLRPWAKESMYHALGYSTIVVLQAVLTFEQQDIQNGISAMKDALQTCQKYRKKYTVVESFSSLLSRGSLEQLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHEIQKNKLQQEFFYEFEGGVKLGTGAFNLMLSLLPARIIRLLEFIGFSGNRELGLLQLREGASGKSMRSALCCLTILAFHTYISLILGTGEVNVAEAERLLAPFLQQFPNGSLVLFYHARIELLKGNLEEAQEVFRKCVSVQEEWKQFHHLCYWELMWINVFQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEDVVATNENVVTLFRQVDSLKQRIAGKSLPTEKFAVRKARRYSASLPAPVKLILPALEMMYVWNGFSIVSKRKDLSENLLVTVEKAEAALQSQNFNSFSVDDECLVKLLKGCCLKNLQRPLQAELCYNHVVESEKLLKYDHYLVPFTLFELASLYKSQGEIDKAIKFLETARNNYKDYSLESRLHFRIQAALHLWRKPSSD
What is the function of this protein?
Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).
What are the official names of this protein?
Tetratricopeptide repeat protein 39B, TPR repeat protein 39B.
What is the protein family that this protein belongs to?
Belongs to the TTC39 family.
Protein: UTP25_PARBA
Sequence: MAAGRGRGGSRPFSVRGGRGRGQKGGRGSRRPTFEASRVAEAHHEDSSEDGSVHLGSDLDAEDQLEAPDESSSSSSDDEEDENRTEKPYNTLLQLLNTGQGVGGPARKRRKMDHNSKKVDVEVKGSDESDAEGLLLESEGEESSEGEEMEDMPMDEVRTENSGDENDASDPFEIHFSNVDSTLLSQKIKAISSKGWQSHKSELPGKLRLMASQPNTEGHIIQVLPATQGVDNLKLKQKLAKHAGDHISKLDSLASSLVPYIFGYQDLLFGARTLSNSATFRDLYCLHVLNHILKTRDRVLKNNSRLQKEPESDLELRDQGFTRPKVLIILPTRQACVRVMESITKLYQAEQQENKARFYETFSAADDKSWEHKPDDFRELFGGNDDDMFRLGLKFTRKTIKYFSQFYNSDIILASPLGLRMVMDKEDGEKQDFDFLSSIEIAIVDQADALLMQNWEHTEYVFSHLNLQPKESHGCDFSRVRNWYLDDQAKYVRQTLTFSSFITPEINALFSSRMQNTAGKIKATPTYEGAILDIPLPVPVKQTFSRFNSSSPVKDPENRFKYFTSTVLSSLIRSFTGRGGTPRASGTLIFIPSYLDFVRIRNYLATSSQTEHLSFGAISEYTSVRDVARARTHFFSGRHSVLLYTERTHHFRRYQIRGVKRIIMYGVPENPVFWGEVVGFLGLDPAGAAEAAEGGVRALFSKWDALKMERIVGTKRLGNMLMEKGGDTFSFV
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NTNH_PARBF
Sequence: MDIIDNVDITLPENGEDIVIVGGRRYDYNGDLAKFKAFKVAKHIWVVPGRYYGEKLDIQDGEKINGGIYDKDFLSQNQEKQEFMDGVILLLKRINNTLEGKRLLSLITSAVPFPNEDDGIYKQNNFILSDKTFKAYTSNIIIFGPGANLVENKVIAFNSGDAENGLGTISEICFQPLLTYKFGDYFQDPALDLLKCLIKSLYYLYGIKVPEDFTLPYRLTNNPDKTEYSQVNMEDLLISGGDDLNAAGQRPYWLWNNYFIDAKDKFDKYKEIYENQMKLDPNLEINLSNHLEQKFNINISELWSLNISNFARTFNLKSPRSFYKALKYYYRKKYYKIHYNEIFGTNYNIYGFIDGQVNASLKETDLNIINKPQQIINLIDNNNILLIKSYIYDDELNKIDYNFYNNYEIPYNYGNSFKIPNITGILLPSVNYELIDKIPKIAEIKPYIKDSTPLPDSEKTPIPKELNVGIPLPIHYLDSQIYKGDEDKDFILSPDFLKVVSTKDKSLVYSFLPNIVSYFDGYDKTKISTDKKYYLWIREVLNNYSIDITRTENIIGIFGVDEIVPWMGRALNILNTENTFETELRKNGLKALLSKDLNVIFPKTKVDPIPTDNPPLTIEKIDEKLSDIYIKNKFFLIKNYYITIQQWWICCYSQFLNLSYMCREAIINQQNLIEKIILNQLSYLARETSINIETLYILSVTTEKTIEDLREISQKSMNNICNFFERASVSIFHTDIYNKFIDHMKYIVDDANTKIINYINSNSNITQEEKNYLINKYMLTEEDFNFFNFDKLINLFNSKIQLTIKNEKPEYNLLLSINQNESNENITDISGNNVKISYSNNINILDGRNEQAIYLDNDSQYVDFKSKNFENGVTNNFTISFWMRTLEKVDTNSTLLTSKLNENSAGWQLDLRRNGLVWSMKDHNKNEINIYLNDFLDISWHYIVVSVNRLTNILTVYIDGELSVNRNIEEIYNLYSDVGTIKLQASGSKVRIESFSILNRDIQRDEVSNRYINYIDNVNLRNIYGERLEYNKEYEVSNYVYPRNLLYKVNDIYLAIERGSNSSNRFKLILININEDKKFVQQKDIVIIKDVTQNKYLGISEDSNKIKLVDRNNALELILDNHLLNPNYTTFSTKQEEYLRLSNIDGIYNWVIKDVSRLNDIYSWTLI
What is the function of this protein?
Expression of the ptox operon (ntnh-orfX1-orfX2-orfX3-pmp1) in B. thuringiensis kills Anopheles but not Aedes mosquito 3rd instar larvae.  The ntnh-pmp1 construct is about half as toxic.
What are the official names of this protein?
Non-toxic nonhemagglutinin, NTNH.
What is the protein family that this protein belongs to?
Belongs to the botulism non-toxic nonhemagglutinin family.
Protein: TBC21_MOUSE
Sequence: MTTLSPENSLSARRSATFILEKRNPPIDKAEWDSFFDENGHLAKSRDFICINILERGLHPFVRTEAWKFLTGYYSWQSSRDERLMVDSNRRRNYNSLCQMYEKIQPLLENLHGNFTETRNNIAYDIQRLYDKDPLGNVLIDKKKLEKTLLLSYVCNTKAEYQRGFHEMVMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNSLITLLDPEFAEHLKGKGSGAVQSLFPWFCLCFQRAFKTFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQALLECMSGDAILMACNNLIDLDADELISAACVVYSELMQKEVPQPLKEFLL
What is the function of this protein?
Acts as a GTPase-activating protein for Rab family protein (s) (PubMed:30360518).  Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (PubMed:32976492).  Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (PubMed:32976492).  Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (PubMed:33536340).  May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978).
What are the official names of this protein?
TBC1 domain family member 21, Male germ cell Rab GTPase-activating protein.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Note=Located at the edge of the acrosomal region, neck and annulus during spermiogenesis. Colocalizes with RAB3A at the acrosome-acroplaxome and neck regions of spermatids. Colocalizes with ACTB at the neck region in elongated spermatids.
Protein: KR134_HYLAG
Sequence: MSYNCCSRNFSSRSFGGYLYYPGSCPSSLVYSTALCSPSTCQLGSSLYRDCQKTCWEPASCQKSCYHPRTSMLCCPCQTTCSGSLGFGSSSCRSQGYGSRSCYSLGNGSSGFRFLKYGGCGFPSLSYGSRFCYPNYLASGAWQSSCYRPICGSRFYQFTC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 13-4.
What is the protein family that this protein belongs to?
Belongs to the PMG family.
Protein: Y5052_PARP8
Sequence: MRTLLLYVVTAVAEIVGCYLPWRWLKEGGSVWLLLPGALSLALFAWLLTFHGTAAGRVYAAYGGVYVAVAILWLWCVDHVRPSAWDLAGVALTLAGMSIIAFQPRL
What are the official names of this protein?
UPF0060 membrane protein Bphy_5052.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF2_CLOD6
Sequence: MSKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELELALEMLGEDLSQENGNVIEIDGKLTVQVLATKLDKSPSEIIMKLMKMGTMATINQEISFEIAALAAKDYGFELTVAESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHGKTSLLDAIRKTDVISGEAGGITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQVTDIAILVVAADDGIMPQTVEAINHAKAAGVPLIVAINKIDKPGANPDKVKQELADQGLLVEDWGGEVIAVPVSAKKKEGIDTLLEMVLLVAEMEELRANPNKRAVGTVIEAELDKGRGPVATVLVQGGTLTVGDPIVAGVACGKVRAMINAKGKRVKTAGPSTAVEILGLSEVPQGGDQFVEVPTDKIARSVAARRQQIVRDEMLKSTQRLSLDALFSQMSEGSIKDLNIVIKADVQGSVQAVKQSLEKLSNEEVQVKVIHGGVGAVTESDILLAAASNAIIIGFNVRPVPGAESLGEKENVDIRTYTIIYKAIEDIQAAMTGMLDPEYVDEETGKAEIREIYKISGVGTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELAALKRFKDDVKEVNSGYECGMSFVNYNDIKEGDIVEAYITKEVERKL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IBP2A_DANRE
Sequence: MLSYVSCGLLLALVTFHGTARSEMVFRCPSCTAERQAACPMLTETCGEIVREPGCGCCPVCARQEGEQCGVYTPRCSSGLRCYPKPDSELPLELLVQGLGRCGRKVDTEPTGSAEPREVSGEVQDPLDIGLTEVPPIRKPTKDSPWKESAVLQHRQQLKSKMKYHKVEDPKAPHAKQSQCQQELDQVLERISKITFKDNRTPLEDLYSLHIPNCDKRGQYNLKQCKMSVNGYRGECWCVNPHTGRPMPTSPLIRGDPNCNQYLDGQEMDPSVDPPN
What is the function of this protein?
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.
What are the official names of this protein?
Insulin-like growth factor-binding protein 2-A, IGF-binding protein 2-A, IGFBP-2-A, IGFBP-2a.
What are the subcellular locations of this protein?
Secreted.
Protein: KCNT2_HUMAN
Sequence: MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLENPSQGNEWSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRIPFILEIINAVPFIISIFWPSLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLIGVRREDNKNILLNPGPRYIMNSTDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAIDLQDTSCRSASGPTLSLPTEGSKEIRRPSIAPVLEVADTSSIQTCDLLSDQSEDETTPDEEMSSNLEYAKGYPPYSPYIGSSPTFCHLLHEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISITRLLLGLDTTPGSGFLCSMKITADDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESQISISVEEWEDTKDSKEQGHHRSNHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRIELNDVVYLIRPDPLAYLPNSEPSRRNSICNVTGQDSREETQL
What is the function of this protein?
Outward rectifying potassium channel.  Produces rapidly activating outward rectifier K(+) currents.  Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600).  Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity).  Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497).
What are the official names of this protein?
Potassium channel subfamily T member 2, Sequence like an intermediate conductance potassium channel subunit, Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSBD_ATRBE
Sequence: MTIALDKFTKDENDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFAVGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.