PharMolix/UniProtQA huggingface dataset:
Protein: VE6_HPV68
Sequence: MALFHNPEERPYKLPDLCRTLDTTLHDVTIDCVYCRRQLQRTEVYEFAFSDLCVVYRDGVPFAACQSCIKFYAKIRELRYYSESVYATTLETITNTKLYNLLIRCMSCLKPLCPAEKLRHLTTKRRLHKIAGNFTGQCRHCWTSKREDRRRIRQETQV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: RF1_TRIL1
Sequence: MFDKIQDLEIRFQELESLLSDPTVIANQPEFRKLSREHADLAPLIEAFRRYKKVLDELEENQELLADPEMKEMAEEEISRLSQEKERLDAEIKILLLPKDPNDSRDVILEIRAGTGGDESALFSGDLFRMYSRFAEKNRWKVEMLSCSESERGGYKEVIASIEGQDVYAKLKYESGTHRVQRVPETEAQGRIHTSACTVAIMAEAEDVDIDINPADLKIDVYRSSGAGGQHVNTTDSAVRITHIPTGTVVACQEERSQIKNRAKAMKVLKTRILDTIQQEQNAKLAADRKQQVGSGDRSERIRTYNFPQGRMTDHRIGLTLYRLDSIMAGDIEEITDALRAHYQMEALKAQSEGA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_PSEAB
Sequence: MAGKTLYDKLWDMHLVKQRDDGSALIYIDRHILHEVTSPQAFEGLRLAGRKPWRIDANIATPDHNVPTTRTERKGGIAAIADEVSRLQVQTLDENCDDFGITEFKMNDVRQGIVHVVGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMKNMLVKVEGRLPAGVTAKDIVLAVIGRIGTAGGNGHAIEFAGSAIRDLSIEGRMTICNMSIEAGARVGLVAVDQKTIDYVKGRPFAPSAEQWDQAVACWQGLVSDADARFDTVVELDAAQIKPQVSWGTSPEMVLAVDQNVPDPARESDPIKRGSIERALKYMGLRPNQAITDIQLDRVFIGSCTNSRIEDLRAAAEVARGRKVAATIKQALVVPGSGLVKEQAEKEGLDRIFIEAGFEWREPGCSMCLAMNPDRLESGEHCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAVNGRFIDVRELLA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: PYRF_AURPU
Sequence: MSRHATITQSYQERASLPKTSPVASYLLRLIAAKKTNLCVSADVSTTRELLQLAEEVGDSICMLKTHADIINDFGPRTIEGLKEIAAKKHFLVFEDRKFGDIGSTVQKQFTAGPLQIVRWANIINAHIFPGPAIITALSQARPRCRQLLILAEMSSAGNLMTGSYTEQCVVEARKNPEFVMGFIAQRTLNEQPGDNFITMTPGVQIGATGDGLGQQYNTPEKVIGEAGTDIIIVGRGVYGAQDKRAKAEEYRVRAWKAYEGNWRCYCNKR
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase, Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family.
Protein: PHS_BURP1
Sequence: MIHKLTSEERKTQLESLHHWTAVPGRDAIQRSLRFADFNEAFGFMTRVAIKAQEMNHHPEWFNVYNRVDVTLSTHDANGLTERDIKLAHFIDEVGKHAKAA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: RNY_HELAH
Sequence: MGNGLIYISLEVIVACLISALAMYYVMKKIYYARGQAVLKSASAKAKLMEFQAKSFVEAEEMRMKSQECKLQQQYENKNLQLKAHFDKKEAYLKHLEAQHKEFVRDEKRYLEKEKQELEKERQILEQEKENFKKQYATCKENQSKALDVMLNYMAYTKEEIKSMILKQLEEELEAQKSALIRRYEKEAKEESKKKSYAILAEATARFAGNYAIENFTNRIALPCSEYIGRVIGKDGKNIEAFKKISGVDIEFSEGDKELCLSSFNIFRREVASETLKILIEDGRIQPNRIEEVYHRVVRNMEKELLSEGQSVVLELELGAMEDELKILLGKMRYRSSFGQNALQHSKEVALLAGLIAEQLGGDKKLARRAGILHDIGKALTQELGRDHVSLGVEVCKRNKEDPVVINAIYAHHGHEEIMSIECASVCAADALSAGRPGARRKSDEEYAKRMQALEEIALGFEGVEKAYAMESGRELRVIVKSNQVRDNQVPIIARKIAKKIEESAQYVGEVGVQVVRESRFKTTATLKQ
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: AMPA_ENT38
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNTYWKVRQAVETAKESLYSFDQLKTTKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAGYLASQARQLADSYSKNIVTRVIGEQQMKELGMHSYLAVGNGSQNESLMSVIEYKGNPSEDARPIVLVGKGLTFDSGGISIKPAEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMSNHNPLAHELIGASEQAGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLARFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLSQFLLNRAGFNGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_RENSM
Sequence: MTTPKNVQVSEKTLEITQIKSTIGGKQNQRDTLRSLGLKRIGHTVVRKADAVTVGMINTIPHLVKVEEAK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: VAMP5_BOVIN
Sequence: MAGKELERCQRQADEVTEIMLNNFDKVLERDGKLAELEQRSDQLLDMSSAFSKTTKTLAQKKRWENARCRIYMGLAVGIALLILLIVLLVIFLPQSSKGSSAPQVQDAGPASGPGE
What is the function of this protein?
May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
What are the official names of this protein?
Vesicle-associated membrane protein 5, VAMP-5.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity).
Protein: COAE_PSE14
Sequence: MTHPDQKPWILGLTGGIGSGKSAAAQCFTNLGIDTVDADHASRWVVEPGRPALEQIAAHFGKGLLQASGELDRGALRKLIFENPEQRRWLEALLHPLINQEIVSHLAKAKSPYAILVSPLLIESGQYRMVQRLLVIDTPAHLQIERTMLRDSSSQEQVEAILKVQIQREDRLRHADDVLVNDRDHAWLNSEVERLHHFYLTLRGGQS
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROF_PLAFX
Sequence: MAEEYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEESDPNFDKWSLFYKEDYDIEVEDENGTKTTKTINEGQTILVVFNEGYAPDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGLHLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAESSQ
What is the function of this protein?
Essential for the invasive blood stages of the parasite.  Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids.  Binds to actin and affects the structure of the cytoskeleton.  Weakly sequesters actin monomers.
What are the official names of this protein?
Profilin, PfPfn.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: COQ9_YEAST
Sequence: MLCRNTARTGCKFFRLYHSNPIEHVKPIHIKPLTYGKESPQYKVLSLALQKFVPEHGFSERSIVESLNELGYPSSMISSIGAPNSPSFFHSSTAVMELIKFQLVDKRYRLTEGINPDVTPQYKLPSLEHLLLKRLEMDKPIGGHLSELMSQLAIPSAFLFETAIPELHRLSDDMIYFSNEKDHHDSAWYAKRLAVSSTYIGSKLFMAQDKSHNYKETFTFAKDKLHRVMRLGEYYNNTEEFAWYTLMSTVNLIKSQLVRG
What is the function of this protein?
Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ9, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COQ9 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: MATK_EHRAN
Sequence: MEEIQRYLQLDRSQQHDCLYPLIFQEYIYALAHDHGLNRSILLENPGYDNKSSLLIVKRLITRMYQQNHFFISVNDSNQDQFFGRNKNLYSQMISEGFAFIVEMTFSLRLISSLEGKEIFKSHNLRSIHSIFPFLEDNFSHLNCVLDILIPHPVHPEILVQTLRFWVKDASSLHLLRFFLHEYWNNLITLKKPSSSFSKRNQRLFFFLYNSHVCEYESIFVFLRNQSSHLRSTSFGALLERIYFYGKIERLVEVFAKDFQATLWLFKDPFIHYVRYQGKLILASKGTPLLMNKWKYYLVNFWQCYFYLWSRPGRIYINQLSNHSLDFMGYLSSVRLNPSMVRSQMLENAFLVNNVIKKFDTLLPIIPLIGSLAKAKFCNILGNPISKPVRADLSDSDIIDRFGRICRNLSHYHSGSSKKKSLYRIKYILRLSCAKTLARKHKSSVRAFLKRFGSGLLEEFLTSEEQVLSLTFPRASSTLWGVYRSRIWYLDIICINDLANHQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LGT_CHLT3
Sequence: MDTSSYIFWDMSPDMFSLGPITIRWYGVFFALSFLCGLYLMTKVFEHEKKPEDDINYLFYYMIAGTVIGARLGHCFFYEPDYYLAHPAEIIKVWHGGLASHGGVLGILTAVYFYSRSRPEQSLAWVLDRITLPAMLGAGLIRLGNLFNSEIIGIPTDVSWAFIFARVDLLPRHPVQLYESIVYFLIFGFLMLAYWKWDWGKQRGLLLGTILTSVFSARFLLEFFKTRQADYGHDLPLSVGQWLSIPAVIIGVLLIFQSVKQAQLEKTS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DTD_DEIRA
Sequence: MRAVVQRVTRAKCTVDGAVTGETGPGLLVLLGVAPQDSADTARTLAAKLAKLRIFNDDAGKMNRSVQDIGGGVLSISQFTLFADTSRGNRPSFTGAASPKQGRELYAEFNAALRALGLPVGEGVFGAHMDIELVNDGPVTVTLDI
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_EDWI9
Sequence: MTTTDNLDAHTPMMQQYLRLKAQHPDILLFYRMGDFYELFYDDARRASQLLDISLTKRGASAGEPIPMAGVPYHAVENYLAKLVQLGESVAICEQIGDPAASKGPVERKVVRIVTPGTVSDEALLSERQDNLLAAIWQSPNGFGYATLDISSGRFRAAEPQDADSMAAELQRTNPAELLYPEEFTSMALIEQRRGLRRRPMWEFELETARQQLNLQFGTRDLSGFGVEQAPQALRAAGCLLQYAKDTQRTMLPHIRAITMERQQDGIIMDAATRRNLELTQNLAGGQENTLAAVLDASVTAMGSRMLKRWLHMPIRDRQALQRRQDAIEALLPLIDDLQPLLRQVGDLERILARLALRSARPRDLARMRVAFQQLPTLQTLLGERGSEALAPLARQAGRFDALCELLERALVETPPVLVRDGGVIASGYHAELDEWRALADGASDYLDRLEVREREKLGLDTLKVGFNAVHGYYIQVSRGQSHLVPIHYVRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYDELFDLLLPHLAALQQSATALAELDVLSGLAERADRYGYVRPQLSERTGINIDEGRHPVVEQVLREPFIANPLTLSGARRMLVITGPNMGGKSTYMRQAALIVLMAHIGSFVPAQRAVIGPVDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEHSLVLMDEIGRGTSTYDGLSLAWACAESLASRIKAMTLFATHYFELTTLPEKLEGVYNVHLDALEHGETIAFMHSVQDGAASKSYGLAVAALAGVPREVIKRARQKLRELETLSQHGNQSQADGAQLPLLVEAEPSAALEALTAIDPDVLTPRQALDWLYRLKGML
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: HEMT1_PHAGO
Sequence: PFDIPEPYVWDESFRVFYDNLDDEHKGLFKGVFNCAADMSSAGNLKHLIDVTTTHFRNEEAMMDAAKYENVVPHKQMHKDFLAKLGGLKAPLDQGTIDYAKDWLVQHIKTTDFKYKGKL
What is the function of this protein?
Myohemerythrin is an oxygen-binding protein found in the retractor muscles of certain worms.  The oxygen-binding site contains two iron atoms.
What are the official names of this protein?
Myohemerythrin-1, MHr-1.
What is the protein family that this protein belongs to?
Belongs to the hemerythrin family.
Protein: ERMC3_STAAU
Sequence: MNEKNIKHSQNFITSKHNIDKIMTNIRLNEHDNIFEIGSGKGHFTLELVQRCNFVTAIEIDHKLCKTTENKLVDHDNFQVLNKDILQFKFPKNQSYKIFGNIPYNISTDIIRKIVFDSIADEIYLIVEYGFAKRLLNTKRSLALLLMAEVDISILSMVPREYFHPKPKVNSSLIRLNRKKSRISHKDKQKYNYFVMKWVNKEYKKIFTKNQFNNSLKHAGIDDLNNISFEQFLSLFNSYKLFNK
What is the function of this protein?
This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.
What are the official names of this protein?
rRNA adenine N-6-methyltransferase, Erythromycin resistance protein, Macrolide-lincosamide-streptogramin B resistance protein.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Protein: RR14_OLTVI
Sequence: MAKKALIQRELKRQKCVAQFAEKRKALKQAIKEASSLQEKLNLHRKLQQLPRNSSAVRLHNRCRVTGRPKGYFRDFGLSRHVLREMAHDCVLPGVTKSSF
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KCAB1_CHICK
Sequence: MQVSIACTEHNLKSRNGEERLISKQNAAAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAEQLMTIAYESGVNLFDTAEVYAAGKAEVILGNILKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLRASLQRLQLEYVDVVFANRPDNNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRAALKCYQWLKEKIISEEGRKQQTKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSNPEQLIENLGAIQVLPKMTSHIVNEIDNILGNKPYSKKDYRS
What is the function of this protein?
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity).  Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity).  Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity).  Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (By similarity).  Binds NADPH; this is required for efficient down-regulation of potassium channel activity (By similarity).  Has NADPH-dependent aldoketoreductase activity (By similarity).  Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).
What are the official names of this protein?
Voltage-gated potassium channel subunit beta-1, K(+) channel subunit beta-1, Kv-beta-1.
What is the protein family that this protein belongs to?
Belongs to the shaker potassium channel beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits.
Protein: Y510_SIRV1
Sequence: MLILLILYFLFLQLHIFDSFIKSIMYDIYIHYAICKFIFLLEIYKLIAMGKRKGQRNIASMKYHLYNKILNRKSFPAFSVMFDAGVESVLPTPLENIQIPLGINTNYGIAYASIISSLLSALNNLAISVFNPNFNSQTFLNLGQSANFGISNGISLLNNYTSLYDNYVQLCNILYQPAVFDETYFDLSVYQPALATEYQNQSCKKIEQYFSSLTTTNVSVNVTTLGTGITNIPNVDNYMYNNIADTGIIDLLNALNINFNQLPDFAKFIIAFIPDLNSIINNGFALDVGWLDRCVLAPETQNGIQLQNGMILQYFADVFGMILDYTPLDFAVLMPEFNPENVTQDDLIAILSADKTVISIFGNLFKMHLYDPSPGGINIAYSSEIENYAVSYQQFLQIQKIVNKKYSNIWYAKMVASATIEIARYPYQQNYSYTSGKRTLSYQDFLNYWKTKWKFYGLTDQDLQYAQQLGEQLQGQAKIENQIKLAQKSAKTKQYKPIFYYKNFQNIAVR
What are the official names of this protein?
Uncharacterized protein 510.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RL35_HELHP
Sequence: MPKMKTNRGAAKRFKLKKNAIKRGSAFKNHILTKKSHQRKANLNAPKYVHSTNVDSVKSLLCMA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: SPEE_ECO45
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTNQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAVHTAAFALPQYLQDALASQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIGW_MOUSE
Sequence: MSQKQLKEAFVRNLSGTSVLEVTQGLCFPAFCILCRGLWIIFSQHVCSFSNTWSTRFLMDFVVLIVPLVITLTVLSSFILLENLTVIVWGAWLLYQIYHRRTCYAKVPVQKVFANFLKISLESEYNPAITCYRVINSVFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFIFGAAMVCPEVRRKSIEESRFNYLRKSLYSVWPLVFLGMGRLVIIKSIGYQEHSTEYGIHWNFFFTIIVVRLVTSLLLIIFPLNKSWIVAVSITVVYQLALDYTPLKRILLYGTDGSGTRVGFLNANREGIISTLGYVTIHMAGVQTGLYVLKGRAQVRDWIKATCWVFSVAVGFFISLHIVQVNIEAVSRRMANLAFCLWVVASSLMLLSCLLLSGIILSFAQFLIKGSLVPCSWKLIQSPTTHKNHSESLILEAEKNQPSLCLITALNRNQLFFFLLSNITTGLINLTMDTLHTGALWTLVVLSIYMFTNCLVIYVLDLQGKTIKFW
What is the function of this protein?
Required for the transport of GPI-anchored proteins to the plasma membrane.  Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.  Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins.
What are the official names of this protein?
Phosphatidylinositol-glycan biosynthesis class W protein, PIG-W.
What is the protein family that this protein belongs to?
Belongs to the PIGW family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LIPB_JANSC
Sequence: MVEWITSDAPVPYPLAVAEMEARANAIAKGEAGEAVWLLEHPPLYTAGTSARESDLRDPDRFPVFETRRGGQYTYHGPGQRVAYVMLDLNTRGKDVRAFVQRLEAWVIAALDDFNVTGAVREGRVGVWVDRPEKAPLPDGTPREDKIAAIGVRLRKWVSFHGLSINVEPDLSHFDGIVPCGIEGHGVTSLVDLGLPVTMADLDVALKRQFFEVFGA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPA2_DICDI
Sequence: MSEELKSLIQPHIDSFDFFTDHGIDLVLKDSEPLYFEHNSTQYKIRFTDLKLSRPTRNIVEKEIKLYPNESRETGTTYNAPFKGAIGLYEVNEMDEMDDGTEVDYNKQEPTHTFEVDLGRLPIMVKSRYCHLNGMSPEKLIESREEELEQGGYFIVNGNEKVVRMLVMTKANHPVALHRKAWTNRGPGYTKNGITIRCVRPDRSSITNNLHYINDGQTTLRFLYRRQEFFLPATLLLKALKDTTEKEIYENIVQGDNENTFLTDRVELSLREQKINNINTQEEVLDYIGSRFRARTQFPPSFSNIKIGRWFINQFVFVHLPNYNDKYNLLILMIQKLYAMVGGKCGTDNIDSPAFQEVLLAGHIYGMILKEKLTEYLESTKSFVLKSFEDKKKSGDKLPDALKKVLDKNFKIADRFSYFLATGNLRSSSGIDLQQTSGFCVIADKLNFLRFISHFRSIHRGAFFATMKTTAIRKLMPESWGFFCPVHTPDGAPCGLLNHLSSNCLVTVDAAQDPTVQKAQTLLPSFLAAHGMLPIDMVSVYQHQYLTITLDGRVLGKIEPKAGEEMVKMLRYLRSMGNEPSIPKTMEISYAPPTNVENGQYSGISLFTTGARFMRPVVNLTSGQNELIGPQEQLYMEIAVVPHEVIKGVTTHIETSPTAMFSLLANLTPFSDYNQSPRNMYQCQMAKQTMGTPLHSYPFRTDNKLYKVQNVQKPIVHTKNQFKFRCNDYPHGCNAVIAVISNTGYDMEDAMIINKSAYERGFGHGSVYKNEYIDLDQGLSRFEQKKTFFGRPNTVVDELDKFIDTDGLPFVGRLIKPGEPYYTYIRPSDGRQVTKDYKGKEEAYIEDVRIIFGPNGATRDPSKINNICVKLRFNRNPVIGDKFSSRHGQKGVLSQLWPEINMPFTESGMKPDVIINPNAFPSRMTIGMLVEILAGKAGAIHGKFQDATAFQFDENNTAIDFFGEQLAKAGFNRFGNEQMYSGTTGKEFECEIFFGVCYYQRLRHMVKDKYQVRALGKVNALTRQPIKGRKVGGGIRFGEMERDSLLAHGASFCLNDRLMKSSDFAKIKVCKLCGSTLTIYSKKDYSNQTVSECKSCKSSDSIATISIPYVFTYLVAELAAVNITMKLQVS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors.  Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit.  Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase I subunit rpa2, DNA-directed RNA polymerase I polypeptide 2, RNA polymerase I subunit 2.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL4_SULIK
Sequence: MYLELVKKNSVILDKDGNKVKEVELPFIFSFPVRKDIIRRVFLAEFTHSLQPKGRDPMAGKRTSAESFGINLGMARVPRVKNSGEAALAPNTVGGRLTFPPSVDKKLVEEVNDKEKQLAVISALSATADTVFVKARGHVFKDSVSFPIVVTDDIVSLKTASEVEEFLEKIGVYDDVKRVKERIRIRAGKGKMRGRKYKEPIGPLIIVHDSNSPIVKAARNIAGVDVVNAKDVSVIHLAPGAHPGRLTIYTETSIKILDERLSKRLVS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.