PharMolix/UniProtQA huggingface dataset:
Protein: GATB_STRPF
Sequence: MNFETIIGLEVHVELNTNSKIFSPSSAHFGEDPNANTNVIDWSFPGVLPVMNKGVIDAGIQAALALNMDIHKEMHFDRKNYFYPDNPKAYQISQFDEPIGYNGWIDIKLEDGSTKKIRIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMRSPEEAYAYLTALKEIIQYTGISDVKMEEGSMRVDANISLRPYGQEQFGTKTELKNLNSFSNVRKGLEFEVERQAKLLRSGGVIRQETRRYDEANKGTILMRVKEGAADYRYFPEPDLPLYEIDDAWIDEMRAQLPQFPAQRRAKYEEELGLSAYDASQLTATKALSDFFETAVSLGGDAKQVSNWLQGEVAQFLNAEGKTIEEIRLTPDNLVEMIAIIADGTISSKMAKKVFVHLAKNGGSARAYVEKAGLVQISDPAVLVPIIHQVFADNEAAVADFKSGKRNADKAFTGFLMKATKGQANPQVAQQLLAQELQKLRD
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: YEBC_SALTY
Sequence: MAGHSKWANTRHRKAAQDAKRGKIFTKIIRELVTAAKLGGGDPDANPRLRAAVDKALANNMTRDTLNRAIARGVGGDEDSNMETIIYEGYGPGGTAIMIECLSDNRNRTVAEVRHAFSKCGGNLGTDGSVAYLFSKKGVISFEKGDEDTIMEAALEAGAEDVVTYDDGAIDVYTAWEEMGKVRDALEAAGLKADSAEVSMIPSTKADMDAETAPKLLRLIDMLEDCDDVQEVYHNGEISDEVAATL
What are the official names of this protein?
Probable transcriptional regulatory protein YebC.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_METKA
Sequence: MDPRELAERLTERDLRILIHLAESGEATPEELAESLDVDLGPVMRSLYWLEERGLIESEEETHEVYELGDEGKEYAEEGLPELRIVEVLRKIGGEGRLEEVLDRAGVPRKLAGPVLGWLRRKGLAEIKREDGETSLVLLEEEPEDVDQSVLEALAAEGSASVEELARKLEMDEEEVEKALKRLSERGDVLRAREETVKKVRLTERGEEVAEHAPEVLERDWITELKPEHLREGTWKEKEFKPYDVKAPTSPTFPGKRHPLKEVINEIRRIFLEMGFVEVSGPLVESSFWNFDALFQPQDHAAREMQDTFYLKEPAEAELPDEEVVEKVRAVHEDGGDTGSRGWGYEWDEGVARKTVLRTHTTAVSVRKLYEVEGPPLKAFSIGRVYRRETVDYKHLPEFHQCEGIVLAKDVSFRDLLGILEEFYRRMGFEEVRFRPAYFPYTVLSVEPEVYFEEKGDWVELGGAGIFRPEVLQPLGFDPDVVCLAWGLGVERLAMLKLGIDDIRDLYMSDLKTLLELPTARARR
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYCO_RABVP
Sequence: MVPQALLFVPLLVFPLCFGKFPIYTIPDKLGPWSPIDIHHLSCPNNLVVEDEGCTNLSGFSYMELKVGYISAIKMNGFTCTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWKMAGDPRYEESLHNPYPDYHWLRTVKTTKESLVIISPSVADLDPYDRSLHSRVFPGGNCSGVAVSSTYCSTNHDYTIWMPENPRLGMSCDIFTNSRGKRASKGSETCGFVDERGLYKSLKGACKLKLCGVLGLRLMDGTWVAMQTSNETKWCPPGQLVNLHDFRSDEIEHLVVEELVKKREECLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEIIPSKGCLRVGGRCHPHVNGVFFNGIILGPDGNVLIPEMQSSLLQQHMELLVSSVIPLMHPLADPSTVFKNGDEAEDFVEVHLPDVHERISGVDLGLPNWGKYVLLSAGALTALMLIIFLMTCWRRVNRSEPTQHNLRGTGREVSVTPQSGKIISSWESYKSGGETGL
What is the function of this protein?
Attaches the virus to host cellular receptor, inducing endocytosis of the virion.  In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane.  There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
What are the official names of this protein?
Glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: KCTD6_DANRE
Sequence: MDNGDWGHRLTHPVTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRKEADFYQIEPLIQCLNDPKPLYPLDTFEQVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNNFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMDYITKQGFTIRNTRVHHMSERANENTVEHHWTFCRLAYKVED
What is the function of this protein?
Probable substrate-specific adapter of a cullin-containing E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
BTB/POZ domain-containing protein KCTD6.
Protein: C_SENDA
Sequence: MASATLPAWIKMPSFLKKILKLRGRRQEDESRSRMLSDSSTQSYQVNQLTSEETEAGSTIPSTPSKGQALPTEPKVRAREKSRHRRPKIIDQVRRVESLGEQASQRQKHMLETLINKIYTGPLGEELVQTLYLRIWAMEETPESLKILQMREDIRDQVLKMKTERWLRTLIRGEKTKLKDFQKRYEEVHPYLMKEKVEQIIMEEAWSLAAHIVQE
What is the function of this protein?
The different products prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways.  They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2.  Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cytoplasm.  They inhibit IFN-gamma induced serine phosphorylation of STAT1.  Block the IFN-gamma pathway by binding to and stabilizing the parallel form of the STAT1 dimer, further inducing high-molecular-weight complex formation and inhibition of transcription by IFN-gamma.  May also have a role in preventing the cell to enter apoptosis.  Modulate regulation of viral transcription and replication.  Overexpression inhibits the viral RNA polymerase.  The absence of all C', C and Y1 proteins leads to viral delayed growth.  Plays an important role in virion particles release.  Modulates virion shape.
What are the official names of this protein?
Protein C'.
What is the protein family that this protein belongs to?
Belongs to the respirovirus protein C family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Protein C' seems to localize around the Golgi.
Protein: EBP2_HUMAN
Sequence: MDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKDQKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKVQTEVLQKRQQEKAHMMNAIKKYQKGFSDKLDFLEGDQKPLAQRKKAGAKGQQMRKGPSAKRRYKNQKFGFGGKKKGSKWNTRESYDDVSSFRAKTAHGRGLKRPGKKGSNKRPGKRTREKMKNRTH
What is the function of this protein?
Required for the processing of the 27S pre-rRNA.
What are the official names of this protein?
Probable rRNA-processing protein EBP2, EBNA1-binding protein 2, Nucleolar protein p40.
What is the protein family that this protein belongs to?
Belongs to the EBP2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner.
Protein: GDIR2_MOUSE
Sequence: MTEKDAQPQLEEADDDLDSKLNYKPPPQKSLKELQEMDKDDESLTKYKKTLLGDVPVVADPTVPNVTVTRLSLVCDSAPGPITMDLTGDLEALKKDTFVLKEGIEYRVKINFKVNKDIVSGLKYVQHTYRTGMRVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDDDKQDHLTWEWNLAIKKDWTE
What is the function of this protein?
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.  Regulates reorganization of the actin cytoskeleton mediated by Rho family members.
What are the official names of this protein?
Rho GDP-dissociation inhibitor 2, Rho GDI 2, D4, Rho-GDI beta.
What is the protein family that this protein belongs to?
Belongs to the Rho GDI family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HEM1_NITSB
Sequence: MQYLVVSFSHKNTDIVTREKLALSDDNKREDVATTLLQNPVINEAIILSTCNRIEIILSVKDPFSATEAVLKKLSEVSGINYEELEGRADIYEDNGAIHHVFSVASGLDSLVVGETQITGQIKDAYKEAYEKGWCGQKLGRVMHYAFKCSKEVRSSTDITRSPVSVASAAVSMAKEKLGNLGGMSALVVGAGEMGRLAAKHLISHGCNVILVGRDLEKTKTVAQEIDPDIRVEHVSNLQKLINSYRLLFSATSSKNPVITKDMVKEQSFDRYWFDMAVPRDIEEIYVARIHYFAVDDLKEIVNKNMAFREEQARNAYKIVGHHVNEFFKWLQTLEIDPIIKEIRKRAKDSALAELQKAIKKGYIPKEYEKSIEKLLHNAFNRFLHDPTKQLKAIADEPRADTIVEAIKFFFEIEEEVGLNRYKCEYYMNLRS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: THIC_NEIMA
Sequence: MTTPKKTAKTSGNEARELADLSEDIGIRFKYPNSERVYLQGSRDDIRVPLREIRQDDTYTAQGAEANPPIPVYDTSGVYGDPAAHIDLKQGLPHIRTVWLDERGDTEILPKLSSEYGIERAHDPKTAHLRFNQITRPRRAKAGRNVTQLHYARQGIITPEMEFVAIRERLKLDELSQKPEYAKLLKQHAGQSFGANIPTHPDQITPEFVRREIAAGRAIIPANINHPELEPMIIGRNFRVKINGNLGNSAVTSSLTEEVEKMVWSLRWGADTIMDLSTGAHIHETREWIIRNAPVPIGTVPIYQALEKTGGIAEDLTWDLFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTANRLTGIVSRGGSIMAKWCLAHHRENFLYTHFDEICEIMKAYDVSFSLGDGLRPGCIADANDESQFAELHTLGELTDKAWKHDVQVMIEGPGHVPLQRVKENMTEELQHCFEAPFYTLGPLVTDIAPGYDHITSGIGAANIGWYGTAMLCYVTPKEHLGLPDKEDVRTGIITYKLAAHAADLAKGWPGAQLRDNALSKARFEFRWRDQFRLSLDPERAESFHDETLPAEGAKIAHFCSMCGPKFCSMKITQEVRDYADKQKAQRQGMEEKAVEFVKKGAKIYS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: GRPE_DICNV
Sequence: MHDPKESLETNIQETESQEKLPETPIIEEEPILTLPDDQINQLQQEVAELKDQLIWQKAENENLRKRQARELENAYKFASERLLKDLLPVIDSLNLGLQAALDTENEAVKQFITGSEMTLTMFQETLARHGIEEINPVGEKFNPELHEAVTMTPSEAHEPNTVIQVTQKGYLLNGRTVRAAQVIVSK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T3HPD_COLP3
Sequence: MTKNIAQAAVKFEQWQPKIEQESYLTINSLECHTGGEPLRIITSGFPVLKGNTILAKANDCKQNYDQLRRALMFEPRGHADMYGAIITDAERDDSHFGAVFIHNEGYSSMCGHAVIALTKTAVESGVVARTGDVTQVVIDVPCGQIYAMAYSHNNVVKHVSFQCVPSFVYAKDQQVEVDGIGMVQFDIAYGGAFYAYVQASSLGLSLVPEQQEKLIAYGRKIKQAIIPQFEINHPTTAELSFLYGVIFIDDSPNQDVHSRNVCIFADGELDRSPTGSGVSGRIALHHAKQQIVLNETITIESILASSFSVRAIETVCFAGFDAVIPEVTGDAYVCGKGQWFINAEDPLKYGFLLR
What is the function of this protein?
Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C).  Together with LhpI, is involved in a metabolic pathway that converts t3LHyp to L-proline.
What are the official names of this protein?
Trans-3-hydroxy-L-proline dehydratase, T3LHyp dehydratase, t3HypD, Trans-L-3-hydroxyproline dehydratase.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: SYS_STRCO
Sequence: MIDLRLLREDPDRVRASQRARGEDVALVDSLLSADERRRSSGVRFDELRAEQKGLGKLIGKAAGDEKAELLKRAEQLKTDVKAADAERDAADAETQELLQRLGNLVHPDVPVGGEEDFVTLETHGTHRDFAAEGFEPRDHLELGQLLGAIDVERGAKVSGSRFYFLTGVGALLELALVNAAIAQATAAGFTPMLTPALVRPQSMAGTGFLGQAAQDVYHLDKDDLYLVGTSEVPLAAYHMDEILDGDRLPLRYAGFSPCFRREAGSHGKDTRGIFRVHQFDKVEMFSYVLPEDSQAEHQRLLEWEKQWLTSLELPFRVIDVASADLGSSAARKYDCEAWIPTQGKYRELTSTSDCTEFQSRRLSIRVREGKKVRPLATLNGTLCAVPRTIVAILENHQQADGSVRVPEVLRPYLGGREVLEPVAK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_SHEB9
Sequence: MYNETPIKRRPSTRIYVGNVPIGDGAPIAVQSMTNTKTTDVEATIAQIRALEKVGADIVRVSVPTMDAAEAFKLIKQAVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRSVVECARDHNIPIRIGVNGGSLEKDLMDKYKEPTPQALLESAMRHVDILDRLNFDQFKVSVKASDVFLAVESYRLLAKQIRQPLHLGITEAGGARAGSVKSAVGLGMLLAEGIGDTLRISLAADPVEEIKVGFDILKSLRIRSRGINFIACPSCSRQEFDVISTVNELERRLEDVTTAMDVSIIGCVVNGPGEALVSHIGLTGGHNKSGYYDEGERQKERFDNDNIVDSLEAKIRAKASQMANRIQIKDTTE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: AEX5_CAEEL
Sequence: MKLIFLLLLFGVSPIVCQDFEDGVFLAKITSIDEHDARKIGRRFGFEAQWKLQSYTDVYVGRRLRRRKRGIEDEIVAEMMLSQQVQFIEKLQGFRRYKRAPMTNKGYPVHVWNLTPSLYIREAWEDGFNASRVTVAVVDDGVDIKHVDLKSAFSPRVSFDFVRFGDLPTPKNSKEFEHGTQCAGLVAMEGQQCGLGVGHGATLGAIKLLGQDFLNDALEGDALAFQKDLIDIYSVSWGPKDDGKSAEKPAKFTEEAIKNGALHGRNGKGNIFVWASGNGGVNGDNCAYDGYVSNEYTLSFGVIDASGAPAAYGEGCSSVLAAVSGGDAMIQTTGLESTCSSISGSSASAAIASGIISLVLDANPTLSQRDIQHLIARTSNASAIRDVELYENSAGLNFHPKVGFGLLNAQKLVVMAATWENVAPQVTCEKMNLANGIIDNSDCDVTKVERVIVSGSIIHPHRGQVQIRLESPRGTISELLPLRPKDTSRDLLDWNFVSVNFFGENSRGIWKLHVTSEEDDVDFRVEMKMFKVVGTMS
What is the function of this protein?
Probable serine endoprotease which cleaves preproteins at paired basic amino acids (PubMed:16945111).  May process FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides (PubMed:16945111).  In muscles, involved in neuronal retrograde signaling by regulating presynaptic activity and localization of synaptic vesicle fusion protein unc-13 at the neuromuscular junction (NMJ) (PubMed:11804572).  Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP) (PubMed:2323555, PubMed:11804572, PubMed:18852466, PubMed:25849533).  Probably by regulating DMP, required for fatty acid uptake by intestinal cells and therefore regulates the levels of triglycerides in the intestine (PubMed:25849533).  Plays a role in locomotion (PubMed:11804572).
What are the official names of this protein?
Endoprotease aex-5, Subtilisin-like protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family. Furin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HR96_DROME
Sequence: MSPPKNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLDIGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEAISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVDSPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAVKPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFDLKTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCNSAANNSQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKPDDTRHNPKLLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDRAAWKVPHTKENMGNIRTDLLKFAEGNIYEEHQKFITTFDEKWRMDENIILIMCAIVLFTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDVERLNKFIINVYLNVNPSQVEPLLREIFDLKNH
What is the function of this protein?
Binds selectively to the HSP27 20E response element.
What are the official names of this protein?
Nuclear hormone receptor HR96, dHR96, Nuclear receptor subfamily 1 group J member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH10_POLAQ
Sequence: MNLRPLHDRVIIKRLDQESKTASGIIIPDAAAEKPDQGEILAVGPGKRDEAGKLNPLDVKVGDRVLFGKYAGQTVKVDGDELIVMREDDIMAVVQK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI46_RAT
Sequence: MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREVLGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGALHPQTILFPCPACQGDVELGERGLSGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPLEATKGCSECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLAYILGNQDTVQTQICELEETIRHTEVSGQQAKEEVSQLVRGLGAVLEEKRSSLLQAIEECQQERLSRLSAQIHEHQSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDGRWGASRERLAISKDQRAVRSIPGLPLLLAAERLLTGCHLSVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDAAVEALPPFAFLTIGMGKILLGSGASSNAGLTGRDGPAASCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
What is the function of this protein?
Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon.  Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons.  Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.
What are the official names of this protein?
Tripartite motif-containing protein 46.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cell projection, axon. Cytoplasm, cytoskeleton. Note=Microtubule-associated. Localizes to the proximal part of the axon.
Protein: ORC2_XENLA
Sequence: MSHEAHNGTKLFKVQFTPDEEVLEHITDKQGVTPQSNTAAQRIVAVKNIIKNDDLHVDEATPESWREQNYVDVLGVDTEDTLQNGPGTGGGDVYSFYTIKRSNKMAQLATEMARTPAKTVSFSVSDNPEEAVSPPANKQTENKTPSKGRKNEFISTTPHRLRKRLSAPSQPSDSESDYSASNSDEELEEKSSAAKTPSKVSQTPGKTPSKKGKKNTASNLVEEYFEAHSSSKVLTSDRTLQRLQTPKLDQETLRKLLDQTPSAFADELHRISKKHEALFYKWMLQLHLGFNIILFGLGSKQSLIEKFRTSLLQDSLHIVINEFFPSITAKSILNSITEEALGHPGAFRSPLDQMDFILQRFKDDPSLELYLLIHNLDSQMLRGEKCQQVLGQLASIPNLHLLASVDHINAPLMWDQSKQSLYNWLWYETTTFGSYIEETSYENSLLVKRSGALALSSLTHVLRSLTPNARGIFRLLAEYQMANKDNPSYTGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGMDGVEYLLIPLDLGTLTDFLEMEDKDT
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
What are the official names of this protein?
Origin recognition complex subunit 2, xORC2.
What is the protein family that this protein belongs to?
Belongs to the ORC2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VF205_ASFWA
Sequence: MVEPREQFFQDLLSAVDQQMDTVKNDIKDIMKEKTSFMVSFENFIERYDTMEKNIQDLQNKYEEMAANLMTVMTDTKIQLGAIIAQLEILMINGTPLPAKKTTIKEAMPLPSSNTNNEQTSPPTSGKTSETPKKNPTNAMFFTRSEWASSDTFREKFLTPEIQAILDEQFANKTGIERLHAEGLYMWRSQFSDEQKKMVKEMMKK
What is the function of this protein?
Induces host endoplasmic reticulum stress and consequently activates autophagy and NF-kappa-B signaling pathway.  In turn, may induce autophagy-mediated STING1 degradation and innate immune evasion.
What are the official names of this protein?
Uncharacterized protein K205R, pK205R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus K205R family.
Protein: YQ02_CAEEL
Sequence: MEDVDLGKDRTQLIDFVYANGNGSASNLNNRNNIPLSEKAAKEPLQTQPQEAPPAPKPKVQKQKPPVKPKKRIACSPGSAICLFLLAVAAIIFAAFLGHYLTKQNYEMMQFKSANESMTTCKNFTRSHKKHQDIVNEEDADENASIKQPTKEELALPKNVQPVWYDVSLSPKVGGNGTMGLAHVKLNIEEPTNKIVLNAKDIEFTRNLEKIQLSKEVTKRAKKSVDSGTNSTSEMPEGSGEEAMATTATTTTTESTTPVSSFVDTGIKVTNIEFDENLEKVTLTLDQELKKGSTVVLKIPFTSKVSNNNGLKEYKYKNSEGKEQSMFTTQPSYSYLRHVFPSFDQEAFKAPAAITLMHSKGSIVVANTGVKTKDDGDAQTSTLNKVLDPDFVIGDLVASEVNTTSGITIRIWTRPEVKHSTEQSLDYANQAIDAMEHILQSRLESKSLDIVAVPGFQTGNRVSPSFIVLPEEDILYNEQSNDINQKTRIARMISNRIAAQWFGGITNPEEFGTFWLNEALPRFLEVEALEKILDINSDDLWTYEMEKILERDATATSQPLRVKNVFSSADIAEIDHEFIGKKGAAVLRMIQKSVGVNVFNKAIRSFVSSYRSAYPYDDGLWKSFEKALGGKLKGWNNEPLDVAKFVNTWVDQIGFPLVSVEKLDDETVELSQERFKNDHKTKEQFKFRNAKYWFNWEVPLFLKSSGPVGNVSWLHEAFRLPLNTSDSIYLNTDSNGVYRVNYEEKRWNDIAKQLEKSHGKLSERTRARLISDVFALANSGALPFETALNVTSYLPMETATVPWLIATRIFKKLTERLEGAPIQDKLNSFIYQKIHKKFEEISSSPGEASSNYLKNRLYANLLDLMAIVKPEKSNEKLNELFVEGFLAPCQFSGNFSSDCSEVPGDLREKVYCNGVEFGNDTVFETVRELAEKEVDGAEKDLLQNSLACFRDPRALRRLILDNLNSTSTVTLLLRKMNSRPVGKEIATNWIIDNWSTVLKKKFKNDPETLNAIADAGIILDNEREKSMIETFMEHHHKSTHGIESLDKKIEEATTDIYWRKQKINELNDYLDGKMKGPAKDDEMESSEEQE
What are the official names of this protein?
Aminopeptidase-like protein AC3.5.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: HFQ_NITEU
Sequence: MGVKGQLLQDPFLNILRKERIPVSIYLVNGIKLQGQIDSFDQYVVLLKNSVTQMVYKHAISTIVPAKAISIPIPADTQTEQDEP
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.