PharMolix/UniProtQA huggingface dataset:
Protein: DNAK3_NOSS1
Sequence: MGKVIGIDLGTTNSCVAVLEGGQPIVIANSEGGRTTPSIVGFGKSGDRLVGQLAKRQAVTNAENTIFSIKRFIGRRWEDTETERDRVPYGCVKGRDDTVDVQIRGRNYTPQEISAMILQKLKQDAENFLGEAVTQAVITVPAYFTDAQRQATKDAGTIAGLEVLRIINEPTAAALAFGLEKQDQEQLILVFDLGGGTFDVSILQLGDGVFEVKATSGNNQLGGDDFDGCVVCWMIERFQQQEKIDLAQDKMALQRLREAAEKAKIELSSMASTSINLPFITADETGPKHLEMELSRSKFEELVGQLIEATIQPMIQALKDADLKPQDIDKIILVGGSTRIPAVQNALIKFFNGKAPDRSVNPDEAVALGAAIQAGVLGGEVDNLLLLDVTPLSLGIETLGEVFTKIIERNTTIPTSKSQIFSTAVDGQTSVEIHILQGERTMARDNKSLGKFLLAGIPPASRGVPQIEVSFEIDVNGILKVAAQDKGTGREQSIRITNTGGLSTNEVERMRQEAEVFAEEDRRRKELVELKNQADNLLIIYESTLKDNGDLIGEQIKVLANEKVAQIQSVMTNPAISLKEFQQCLDDFQQTLFSIGANVYQRANTQTDDELEVMSDGSSPSDIEHPISGTLIPQFNFDFDDESTAQADYEAID
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein dnaK3, HSP70-3, Heat shock 70 kDa protein 3, Heat shock protein 70-3.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FETP_PSEU2
Sequence: MTRTVMCRKYKEELPGLERAPYPGAKGEDIFNHVSQKAWADWQKHQTLLINERRLNMMNAEDRKFLQTEMDKFLSGEEYAQAEGYVPPEK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: H31_TETTH
Sequence: MARTKQTARKSTGAKAPRKQLASKAARKSAPATGGIKKPHRFRPGTVALREIRKYQKSTDLLIRKLPFQRLVRDIAHEFKAELRFQSSAVLALQEAAEAYLVGLFEDTNLCAIHARRVTIMTKDMQLARRIRGERF
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  H3 is deposited into chromatin exclusively through a DNA replication-coupled pathway that can be associated with either DNA duplication or DNA repair synthesis during meiotic homologous recombination.
What are the official names of this protein?
Histone H3, H3S, Histone H3-I/H3-II, Major histone H3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to both the large, transcriptionally active, somatic macronucleus (MAC) and the small, transcriptionally inert, germ line micronucleus (MIC).
Protein: LFTR_YERPS
Sequence: MRVTQLSSQSFIFPSPELALREPNGLLALGGDLTAPRLLAAYQRGIFPWFNPGEMILWWSPDPRAVLFPEDLHISRSMRRFIRHCPYRFTLNHAFADVISACATERDEGTWIGRDVQQAYCQLHALGHAHSLEVWLENELVGGLYGVAVGAVFCGESMFSRADNASKSALMVFCHHFTQHGGELIDCQVLNAHTASLGAVEIPRNFFLQQLSQLQFSPLPAECWLPQSLNFSSAMQ
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_BURO1
Sequence: MKTAQELRVGNVVQIGSEAWVIAKAEYNKSGRNSAVVKMKMKNLLSNAGQESVYKADDKFEVVVLDRKEVTYSYFADPMYVFMDADYNQYEVEAEMMGEALNYLEDGMACEVVFYNEKAISVELPTVLVREITYTEPAVKGDTSSGKVLKNAKLATGFELQVPLFCNTGDKIEIDTRTNEYRSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: YR880_MIMIV
Sequence: MNILPYEIHLLVIDYLYNDDLSIYFVNKYFFSMLKHSKIQNTIIKKIIKKGELGVIRYINKLFRVNDELVIGNKLFESSGINNYLLTACKYGHCKLVKYFVECGADIHYKTDYALQLACKYGYLEIVKYLVKKGANINTDDCYAVQLASREGHLKIVKYLVELGTNVRKDRDLAFRWSVENNHLSVTKYLVELGSDVRSEKNYAIKKSCEYGYFEMTQYLMNQGANFRVDNDYAVRFASKKWTFKYCRIFDIMWR
What are the official names of this protein?
Putative ankyrin repeat protein R880.
Protein: HTPX2_SULTO
Sequence: MIWEVTKLRISMILSAIAILVLGFALIYGILGYFFGFSNAPLLITGALAFVTIFTILQWLFGPALIKSIYHLTEVDPTDPQYGWVYNLVQEVAMYNRMNTPKVYIANVPFPNAFAFESPIYGKNMAITLPLLRMLTPEEVKAVIGHEIGHLRHKDTELLLAVGLIPTLLYWIGYGLWWGGLLGGGGGGRNDNSGILFLIGIALIAFSFLFNLFVLFLNRMREAYADVNSAITVPNGAKNLQTALAKIVLSTDPDIIERYKKKYGQIGSMLLFSGFQINEDIPAYKVQELVEYWRNIKVSPFADIFSDHPHPAKRIQLLEKLTHTQ
What are the official names of this protein?
Protease HtpX homolog 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNMA_FRATO
Sequence: MENKKVIVGISGGVDSSVSALLLKQQGYDVTGVFMKNWEEDDTDEFCSAEQDIADAQAVCDSIGIPFKKINFTAEYWDNVFEHFLIEYKAGRTPNPDILCNKEIKFKAFLSYVHLLGGDYIATGHYAQTRLAADGSVQLVKGLDDNKDQTYFLYTLGQEQLRQTIFPIGNIEKSKVREIAKENNLVTFDKKDSTGICFIGERKFKEFLSKYLPAQKGEIHDENGIKIGMHDGLMYYTIGQRQGLGIGGVKDRPEVPWFAAKKDLENNVLIAVQGHDHPLLFKQSLQAIELSWVAGMAPADKFRCAAKVRYRQKDQSCEVEVNQDGSVNVTFDQPQRAITPGQSVVFYIDDVCLGGGVII
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_SYNP6
Sequence: MSLVTALNGLDLFLVGLMGSGKTTIGKLLAESLGYTYVDTDSLIENVTGRSIPEIFASDGEAGFRQIETQVLEEVASYRRLVVATGGGIVIRPENWSYLQQGLVIWLDVPIPELLRRLEGDQNRPLLQTEAPATTLQALWEQRRDRYAQADLRIAIEASEDPEVTMQRILEVIPSVLKNSADSSPAEIET
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPT4H_DANRE
Sequence: MSLETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCESYLQMKGNREMVYECTSSSFDGVIAMMSPEDSWVAKWQRIGNFKPGVYAVTVTGRLPPGVVRELKSRGVIYRSRDTAVKT
What is the function of this protein?
May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.  Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex.  Also acts to stimulate transcriptional elongation at low nucleotide concentrations.  Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity).
What are the official names of this protein?
Transcription elongation factor SPT4, DRB sensitivity-inducing factor small subunit, DSIF small subunit.
What is the protein family that this protein belongs to?
Belongs to the SPT4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZFN2A_RAT
Sequence: MEFPDLGKHCSEPTCKQLDFLPITCDACKQDFCKDHFSYSGHKCPFAFKKDVQVPVCPLCNAPIPVRRGDIPDVVVGEHMDRDCTFHPGRNRNKVFTHRCSKEGCRKKEMLQLACAQCHGNFCIQHRHPLDHNCQAGSSSVSRGRSSASRAAEQKPSGVSWLAQRLRRTVK
What are the official names of this protein?
AN1-type zinc finger protein 2A.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GLYA_CARHZ
Sequence: MTHLNLRLKDVDPEIFEAMEKELSRQREKIELIASENFVSRAVMEAMGSHLTNKYAEGLPGKRYYGGCEYVDVVENLARERAKKLFGAEHVNVQPHSGAQANMAAYMAFLEPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNFVSYGVEPDTEKINYEKVFELAYKHKPKMIVAGASAYPRVIDFKHLKEIADEVGAYLMVDMAHIAGLVAAGLHPSPIPYADVVTTTTHKTLRGPRGGVIFCKAEHAAKIDKTVFPGVQGGPLMHVIAAKAVAFKEALSPEFREYQQQVVNNAKALAEELKKQGLRLVSGGTDNHLMLVDVRPVGLTGKRAEQLLDEIGVTVNKNAIPYDPESPNVTSGIRIGTPAVTTRGMKEGEMAEIAEIIALVLKNPENEDKHREAARKVRDLLNRFPLYDKLPYND
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSC3_KLULA
Sequence: MVFGMNLGNRRKATRVPDLSRYDYHYNGSGGNSVNQGDNYLKSHELSADAAFAASARAGSLVNYPERGYTNISRANSLRMGHPGQQQQQSSYIPRSYSFTARGAYAPRTGNVGNRRSVSAIPRTGTASSRGVGSRTGSMTGSVARVGSRTGSFAGGGNGSIIIKTQEVKDMMGRTQSITTQTIRRINGMEYVETTTQTAGLVEDPQFHFQQFAENDEFPISDELSATPPAAPLSESQPRTNQRLANFNSNAINNSAANNIRSDSEEEGEEHFTDASDVVEESGAFAEDDQDHFLAKVNKVDVDNNSKSYTSRKPLVQKQGVQQQQEVQHQGISQVQNTEAKSVGRKSTMSKRMTLRDTPNAQLEPEKDTTDQATPDNNATKRKSIFKSKKRNEAVAVPTVPTSDQKTLSQEEMYAIALEIAQQKYGHPTKTVSHSTDNGSRNEMTPILEDADVEQPHVLPTTLHLPTREEQIQHEQLQQPTAAIPTNEKSRHPKKKVKSILDRVVQFSQENSGNQPPKQHRGKQYSQQPPDVAPSNGTTDNFDTNASGHNINHNNNNHNNNNNTSSSSSLRHESGANPVVVTEDTTVLAASTAATPVDVNEPGNPDHVIPASSPSIDNTPRINEKTKSKKKNEKGSFFKRLFKSNKTHINTK
What is the function of this protein?
May be involved in the control of meiotic sister-chromatid recombination.
What are the official names of this protein?
Meiotic sister-chromatid recombination protein 3.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Note=Cell periphery.
Protein: CC169_HUMAN
Sequence: MKEERNYNFDGVSTNRLKQQLLEEVRKKDAVQLSIFELRHKITELEAKLNTDNEGSEWKTRYETQLELNDELEKQIVYLKEKVEKIHGNSSDRLSSIRVYERMPVESLNTLLKQLEEEKKTLESQVKYYALKLEQESKAYQKINNERRTYLAEMSQGSGLHQVSKRQQVDQLPRMQENLVKTGRYNPAKQKTVSAKRGPVKKITRPNHLPELHP
What are the official names of this protein?
Coiled-coil domain-containing protein 169.
What is the protein family that this protein belongs to?
Belongs to the CCDC169 family.
Protein: DJC18_MACFA
Sequence: MAATLGSGERWTEAYIDAVRRNKYPEDTPPESHDPCGCCNCVKAQKEKKSENEWTQTRQGEGSSMYSEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPYNYYRDFEADITPEELSNVFFGGHFPTGNIHMFSNVTDDAHYYRRRHRHERTQTQKEEEEEKPQTTYSAFIQLLPVLVIVIISVITQLLATNPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLHDLEKTIEKDYIDYIRTSCWKEKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLIGLRRGG
What are the official names of this protein?
DnaJ homolog subfamily C member 18.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ACDH_ECOLU
Sequence: MSKRKVAIIGSGNIGTDLMIKILRHGQHLEMAVMVGIDPQSDGLARARRMGVATTHEGVIGLMNMPEFADIDIVFDATSAGAHVKNDAALREAKPDIRLIDLTPAAIGPYCVPVVNLEENVDQLNVNMVTCGGQATIPMVAAVSRVARVHYAEIIASIASKSAGPGTRANIDEFTETTSRAIEVVGGAAKGKAIIVLNPAEPPLMMRDTVYVLSDEASQDDIEASINEMAEAVQAYVPGYRLKQRVQFEVIPQDKPVNLPGVGQFSGLKTAVWLEVEGAAHYLPAYAGNLDIMTSSALATAEKMAQSLARKAGEAA
What is the function of this protein?
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A.  Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: QUEC_ECOUT
Sequence: MKRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYGQRHRAEIDVARELALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPEADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVSLGMAKDIRFETPLMWIDKAETWALADYYGKLDLVRNETLTCYNGIKGDGCGHCAACNLRANGLNHYLADKPTVMAAMKQKTGLK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RNH2_STRPS
Sequence: MATIKEIKELLVTVKELESPIFLELEKDNRSGVQKEISKRKRAIQAELDENLRLESMLSYEKELYKQGLTLIAGIDEVGRGPLAGPVVAAAVILPKNCKIKGLNDSKKIPKKKHLEIFQAVQDQALSIGIGIIDNQVIDQVNIYEATKLAMQEAISQLSPQPEHLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELMKEYDQQFPGYDFATNAGYGTAKHLEGLTKLGVTPIHRTSFEPVKSLVLGKKES
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWET1_CAEEL
Sequence: MLEVVLQVLSISAITTTIALFFCGIPICMQIRRQGAVGDISGVPFLMGVLGGSFWLRYGLLKMDYVMIIVNVVGVACMAFYCVFFLIYSLPKKTFTCQLILVTSTIGGMVLWIALKPNLDYLGVICMTFNIMNFGAPLAGLGVVLKNREVSTLPLPMCVANFLVSSQWCLYGNLVSDIYIIIPNGIGMFLAIVQLALFVVLPIRENEKSPLEKLASWFTGRDSKVKDLERGDCIVSSPPSSPQKVPNETRSDVEDKFDKLMAETSSTIPSDSRRGSMGSPPSYKSRSSSDPDLSSIQSP
What is the function of this protein?
Mediates both low-affinity uptake and efflux of sugar across the membrane.
What are the official names of this protein?
Sugar transporter SWEET1, CeSWEET1.
What is the protein family that this protein belongs to?
Belongs to the SWEET sugar transporter family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: AROE_STRMK
Sequence: MTDRYAVFGHPVAHSKSPQIHATFGRQEGIAVDYRAIDLAPEAFLAGLEAFAADGGVGANVTSPHKEAAFSVCTTLTARARRAGSVNTLLRKGDRWHGDTTDGIGLVRDLTDRHGLDLRGRRMLLIGAGGSARSVAPALLDAGITELVVVNRTPERADELIDAMGEPGRAISRYWEDLRDLGDFELIVNATSAGRDRDIEFKLPLSLVNSMTTAVDLNYGEAAIAFLAWARAAECRNTVDGLGMLVEQAAESFLQWHGVRPQTDEVYQSLRQGSAVLAGED
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: MATK_CUPAN
Sequence: MEKFQIYLELDGSQQHNFLYPLLFREYIYALAQDHGLNRSTISLENGGYDNKSSSLSGKRLITLLYQQIHLSISANDSNPNQFIGHNNNLYSQMILEGFAVIVEIPFSLQLVSFLEGKEMAKSQNFQSIHSIFPFFEDNFSHLNYVLDVLIPHPIRPEILVQTFRYWVKDASSLHLLRFFLHEYFNWNSLITPKKSISGFSTSNPRFFLFLYNSHVYEYEFLFFFLRNQSSHLRLTSSGVLLERIHFYGKVDYFVEVFANGFQDILWLYKDLFMHYVRYQGKAILASKDTPLLMNKWKYYFVNLWQWHFHVWSQPVRAHINHLHKDSINFLGYLSSRRRNPLVVRSQMLENAYLIDNAMKKFETAVPIIPMVESLTKARFCNPLGNPISKPIWADSSDSHIIDRFVRICRNLSHYHSGSSKKKSLYRIKYILRVSCVKSLVRKHKSTVRVFLKRLGSEFFQDFLTEEEHVLSLIFSRASFTWRRLYRGRVWYLDIICINDLVNHDKF
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NS1_HRSVA
Sequence: MGSNSLSMIKVRLQNLFDNDEVALLKITCYTDKLIHLTNALAKAVIHTIKLNGIVFVHVITSSDICPNNNIVVKSNFTTMPVLQNGGYIWEMMELTHCSQPNGLLDDNCEIKFSKKLSDSTMTNYMNQLSELLGFDLNP
What is the function of this protein?
Plays a major role in antagonizing the type I IFN-mediated antiviral response by degrading or inhibiting multiple cellular factors required for either IFN induction or response pathways (PubMed:15047850).  Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3 (PubMed:15827150).  Also disrupts the association of IRF3 with CREBBP (PubMed:21632562).  Interacts with host mitochondrial-associated membrane (MAM) MAVS and prevents the interaction with RIGI (PubMed:22383950) (Probable).  Interacts with TRIM25 to suppress TRIM25-mediated RIGI ubiquitination and thereby RIGI-MAVS interaction (PubMed:30558248).  Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C (PubMed:17251292, PubMed:23877405).  The degradasome requires an intact mitochondrial MAVS (PubMed:23877405).  Decreases the levels of host TRAF3 and IKBKE/IKK-epsilon (PubMed:19625398).  As functions other than disruptions of the type I IFN-mediated antiviral signaling pathways, induces host SOCS1 and SOCS3 expression (PubMed:24480984, PubMed:26557722).  Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth (PubMed:17151097).  Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication (PubMed:9445048).  Suppresses proliferation and activation of host CD103+ CD8+ cytotoxic T-lymphocytes and Th17 helper T-lymphocytes (PubMed:21533073).
What are the official names of this protein?
Non-structural protein 1, NS1, Non-structural protein 1C.
What is the protein family that this protein belongs to?
Belongs to the pneumovirus non-structural protein 1 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host mitochondrion. Host nucleus. Note=Most NS1 resides in the mitochondria as a heteromer with NS2.
Protein: 3SO3_BUNMU
Sequence: MKTLLLTLVVVTIICLDLGYTRKCLIKYSQANESSKTCPSGQLLCLKKWEIGNPSGKEVKRGCVATCPKPKKNEIIQCCAKDKCNK
What are the official names of this protein?
Short neurotoxin homolog NTL4.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group III sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA1_PEDPA
Sequence: MANILKKWVESDARELKRLGKKADKIEALKEEMEQLNDEKLKAKTTEFKERLQNGETLDDILVEAFAVAREAAKRVLGLFPFRVQLIGGMVLHGGNIAEMKTGEGKTLTATLPVYLNALGGKGVHVVTVNEYLAERDSSEMGELYKWLGLTVGVNSSEMTPDQKREAYNCDITYSTNSEIGFDYLRDNMVVYKEDMVQRPLNFALIDEVDSILIDEARTPLIISGQTEPTVTLYERADRYVKTLADGDYTIDWESKSISLTENGIRRAENFFKTDNLYDVENSALNHHIDQALRANYIMTKDKDYVVSDGEVLIVDSFTGRVMEGRRFSDGLHQAIEAKEHVEIQDGAKTMANITYQNLFRMYRKLSGMTGTARTEAEEFREIYNMEVTTIPTNRPVARDDRPDLLYPTLESKFKAVVKEIRDLHIKGQPVLVGTVAVETSEYLSRLLDREGIPHVVLNAKNHAREAEIVTNAGQKGAVTIATNMAGRGTDIKLGPGVVELGGLAVIGTERHESRRIDNQLRGRSGRQGDVGMSQFYLSLEDDLMIRFGSERIKDLLSRMKIADEDAVIRSGLISRQVESAQKRVEGNNYDARKNVLQYDDVMRAQREVIYAERQQVIMEETSLKDVLMPMVDRTIDRVVDAHTQKTQKNFDLETIVEFARTALVSDKDIHQADVEGMSAKEIKDYLKQLADQMYIEKEKALYDPAQILEFEKVVILRVVDQHWTDHIDAMDQLRQSVGLRGYGQLNPLVEYQQEGYRMFNEMITDIEYETTRLFMKSEIRQNLQR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 1.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: NUOB_RHOCS
Sequence: MGVIATPPPSVQGPSSQVPSSAPIPPGPVQDAYLQAVQQEMQDKGYLVARFDALMDWARTGSLWPMTFGLACCAVEMIHAYMARYDLDRFGVIPRPSPRQSDVMIVAGTVCNKMAPALRKVYDQMAEPRWVISMGSCANGGGYYHYSYSVVRGVDRIVPVDIYVPGCPPTAEALVYGVLQLQKKIKNGNRLIRT
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CSRA_XANAC
Sequence: MLILTRRVGETLMIGDSVTVTVLGVKGNQVRIGITAPKDVAVHREEIYQRIQRGDEPVASGAHHGDDSSN
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMKL_FRATW
Sequence: MQKFTFFVSCAKGIELLLKDELERLGISSQEKLAGVEFEGSIKDAYKVCIYSYLASQVMLKVATDKVINQQDLYEFISSINWMDYFAVDKTFKIIISGKHYDFNNTMFVSQKTKDAIVDQFRNVTNQRPNIDTENPDNVIKLHLHKQFVNVFLCLNIDSLHKRSYRQFQGQAPLKESLAAAILIKAGWLEELKKHQPILIDPMCGSGTILIEAALMAKNIAPVLLNKEFKIFNSKFHNQELWDNLLEIAKNSQKVTNAIICGFDIDNNVLDKAQRNIYQAGVEDVVTVKRQDIRDLENEFESEGLIVTNPPYGERLYGDQLDELLDIFNGFGDRLSQDFYGWKVAVLTSFADSIKEMQLRTTERNKFYNGAIETILYQFEINEHAKFKHETQLEKNIRIAEASAQKSDEHIDFANKLKKNLKSLKPWLKQTGLECYRLYDADIPTFAVAVDVYSEHIFLQEYRADATIDQNIAKQRFYQAIYQIHKTLDIKYENIHTRVRQRQKGKEQYQKENDKNKFHIINEFDAKFYVNFDDYLDTGIFLDHRKIRQLVAKAAKNKTLLNLFSYTCTASVHAALKGAKTTSVDMSNTYLEWGKNNFTLNNIDAKKHSFIQADCISWLKTNKDKFDVIFLDPPTFSNSKRMDDILDIQRDHELLINLAMDSLKKDGILYFSNNYRRFKMSPQILEKFNCENIDKICLSRDFLSNKNIHNCWEIKYK
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACD_STRPN
Sequence: MALTEQKRVRLEKLSDENGIISALAFDQRGALKRLMVKHQTEEPTVAQMEELKVLVADELTKYASSMLLDPEYGLPATKALDEKAGLLLAYEKTGYDTTSTKRLPDCLDVWSAKRIKEEGADAVKFLLYYDVDSSDELNQEKQAYIERIGSECVAEDIPFFLEILAYDEKIADAGSVEYAKVKPHKVIGAMKVFSDPRFNIDVLKVEVPVNIKYVEGFAEGEVVYTREEAAAFFKAQDEATNLPYIYLSAGVSAKLFQDTLVFAHESGANFNGVLCGRATWAGSVEAYIKDGEAAARECVRTTGFENIDELNKVLQRTATSWKERV
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase, D-tagatose-1,6-bisphosphate aldolase, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: LPXA_ANAD2
Sequence: MAIHPTAIVEAGAQVDPSCDIGPYAVIGPLVRMGPGNSVGAHAVVTGRTTLGASNRIFPHAVIGGIPQDLKYRGEDTALVIGDRNTFREFATVNLGTAGGGGVTRIGSGGLFMASSHIGHDCQVGDGAIIANSVAIAGHVLIEDHVHFGGLSASHQFCRVGRLAFVGGMTGVAMDVAPYCTVAGARGELAGLNTIGMQRAGMTEEQVGRVKQAYKIVFRSSLGLAEAIAQLEAELAGHPETDHFIAFLKGSQRGITR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.