PharMolix/UniProtQA huggingface dataset:
Protein: ANGI_RHIRO
Sequence: MVMGLGLFLLVFMLGLGLTPPTLAQDNSRYRDFLTKHYDATPQGRNDRYCESMMRRRGLTSPCKDINTFIHGNSRHIKAICGDENGNPYGENLRISKSPFQVTTCNLRGGSSRPPCRYRATAGFRNIVVACENDLPVHLDQSIFRP
What is the function of this protein?
Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs).  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus.  Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA.  Angiogenin induces vascularization of normal and malignant tissues.  Angiogenic activity is regulated by interaction with RNH1 in vivo.
What are the official names of this protein?
Angiogenin, Ribonuclease 5, RNase 5.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: HIS7_BACC7
Sequence: MRESSQIRETTETKIKLSLQLDDGKNVSVRTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKEALHSKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTHHKIEALFKAFGRALREAVERNANITGVNSTKGML
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XXLT1_MOUSE
Sequence: MGLLRGGAACARAMARLGALRSHYCALLLAAALAVCAFYYLGSGRETFSSATKRLKEARAGAAAPTPPAPELARGSAAPASGAKAKSLEGGVVVPVDYHLLMMFTKAEHNAPLQAKARVALSSLLRLAKFEAHEVLNLHFVSEEASREVAKALLRELLPPAAGFKCKVIFHDVAVLTDKLFPVVEAMQKYFSAGSGTYYSDSIFFLSVAMHQIMPKEIPRIIQLDLDLKYKTNIRELFEEFDNFLPGAVIGIAREMQPVYRHTFWQFRHENPKTRVGDPPPEGLPGFNSGVMLLNLEAMRQSPLYSHLLEPSWVQQLADKYHFRGHLGDQDFFTMIGMEHPELFHVLDCTWNRQLCTWWRDHGYSDVFQAYFRCEGHVKIYHGNCNTPIPED
What is the function of this protein?
Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose.  Known targets include Notch proteins and coagulation factors, such as F9.
What are the official names of this protein?
Xyloside xylosyltransferase 1, UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: COX3_POLOR
Sequence: MAHQAHAYHMVDPSPWPLTGAVAALLLTSGLAVWFHFKSLTLLAMGLLLMILTMIQWWRDIIREGTFQGHHTPPVQKGLRYGMILFITSEVFFFLGFFWAFYHSSLAPTPELGGIWPPTGITPLDPFEVPLLNTAVLLASGVTVTWTHHSLMEGKRTEATQALTLTILLGLYFTALQAMEYYEAPFTIADGVYGTTFFVATGFHGLHVIIGSTFLAGCLLRQILYHFTSSHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DSS1_YEAST
Sequence: MVVRRKVHVLLIARSFHSYTPCFRVTTRGKRQRSKSKQQAKVELDHTRELDNDQATETVVDRSVGPEKDIESINKDFLQRTKGLEPDIELKQLPQIKQEFNQRYKDRYVKPSEDWYVNSWRSLTKPKIPLYKLINSDFQLITKLKAPNPMEFQPVQLMESPLNVGDFVLLKMRPNELAMCVSLPSSTMDPRYTFVTIDGTMCFATKNRVLLRIPHKLPAGIHSLIQPESHHKHLPIGTVKNFSNQTNILPIVARQLITSRYPAQISKLAWKDLPITTKKLQLLHRSLQNYMGPWQIPFFTLVGLVQKLDLNKALDDKNGINYLTSLVNNYHTVNDIPINSPTFVSTYWAIMQQQESNLWGEIHLNTALLSPISVTIIPLKSQHLYYAQVIEKLEANSYREVNKFVKLVNERKYRDISALYPSVIQLLKDFAAGNFHNNGIIVALISKIFRKIERYKDCDITRDICQDLINEITPNSIPNPLLLNMDLALPASSKLVKWQQKLYDLTNIEELQWKKSGTDDDRYDFGDLRVFCIDSETAHEIDDGVSVKNYGRDGLYTLYIHIADPTSMFPESTNVDIEGISTDILNVALKRSFTTYLPDTVVPMLPQSICHLSDLGKQGQRTKTISFSVDVKITSKCSGKSIEIMYDSFKIRKGIVSNFPKATYEDVDRILGTPNSEASPVKKDLESLSMISKLLREQRIKNSNAVIFGEGFNKGLVMLNADSEGELTEVTFSDQEETLSTILVSEMMILANTLTGRYFAENKIGGVFRCYKQLPLGEVAQQQYDSMITSTKKGIFPKLKDIVKLSSLLNSSFYTGRPFRHEMIGAKQYLTVTSPLRRFPDLINHLQIHRHLQKKPLCFNQTQIDSLIWPIQSRADILKRASRNSSTYWTLNYLKKLTKLEPERTFDVMVTSVPQNGFTGCVFPDLSFARGTLKLHPSSMHYPMIGDIVKNCKISKIDCLEGMLELEKL
What is the function of this protein?
Required for intron-independent turnover and processing of mitochondrial RNA.  Participates in 3' mtRNA processing where it hydrolyzes single-stranded RNA or partially double-stranded RNA with 3' single-stranded tails.
What are the official names of this protein?
Exoribonuclease II, mitochondrial, RNase II, Ribonuclease II, Deletion of SUV3 suppressor 1, Mitochondrial biogenesis protein MSU1.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CRGA_MYCBT
Sequence: MPKSKVRKKNDFTVSAVSRTPMKVKVGPSSVWFVSLFIGLMLIGLIWLMVFQLAAIGSQAPTALNWMAQLGPWNYAIAFAFMITGLLLTMRWH
What is the function of this protein?
Involved in cell division.
What are the official names of this protein?
Cell division protein CrgA.
What is the protein family that this protein belongs to?
Belongs to the CrgA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NANP8_HUMAN
Sequence: MSVDPACPQSLPCFEESDCKESSPMPVICGPEENYPSLQMSSAEMPHTETVSPLPSSMDLLIQDSPDSSTSPKGKQPTSAENSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSSYHQGCLVNPTGNLPMWSNQTWNNSTWSNQTQNIQSWSNHSWNTQTWCTQSWNNQAWNSPFYNCGEESLQSCMHFQPNSPASDLEAALEAAGEGLNVIQQTTRYFSTPQTMDLFLNYSMNMQPEDV
What is the function of this protein?
May act as a transcription regulator (By similarity).  When overexpressed, promotes entry of cells into S phase and cell proliferation.
What are the official names of this protein?
Homeobox protein NANOGP8.
What is the protein family that this protein belongs to?
Belongs to the Nanog homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PHKG1_HUMAN
Sequence: MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFSPRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEDY
What is the function of this protein?
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase.  In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity).
What are the official names of this protein?
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform, PHK-gamma-M, Phosphorylase kinase subunit gamma-1, Serine/threonine-protein kinase PHKG1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Protein: SYDP_ECOHS
Sequence: MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: YP205_YEAST
Sequence: MYPFYKYIFSFWFFFLVEYVVTFRLFLSLKSGNIFLSTQQRFKDATKMCFHHQMLSSSVEPFFSLYFNHVPYMWSCFNFFSSSPFPRCTKNSPEKKKFKRGLPISSKYTDGKKR
What are the official names of this protein?
Putative uncharacterized protein YPL205C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AMPA_PROM2
Sequence: MQFSTFQKNLDDWQGSSLIFGVLEEEIASQLENIKFVIDPKLLLKKVTQKKFKGEKGEILSFEFLDQNLETLFIVGLGKLKDLNKSDIENSIGNLVRKTVDKNEKMSILLPWEFINSQLEINQLAESVRLSAYKDNRFNKKKDEKKVLKEIEFLNLKKFENISFEETAQICEGVELARRLVAAPPNSLTPQEMSIQASQIAKDHGLGVKILEAKDCEDLGMGAYLAVAKGSDLDPKFIHLTLKSEGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVASCENMINGSAVHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLKPDSIIDLATLTGAIVVALGNDVAGFWSNNDNLANDLKAASAQSGEELWQMPLQKSYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDKEIKWAHIDIAGTCWTDKNKGINPSGATGFGVKTLVQWIKNK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_MACCJ
Sequence: MPIITDVYAREVLDSRGNPTIEVEVFTESGALGRALVPSGASTGEHEAVELRDGDKDRYMGKGVLKAVENVNEIIAPEIIEGDFSVLDQVSIDKMMIALDGTDNKGKLGANAILGVSIAVARAAADYLGVPLYKYLGGFNGTELPVPMMNIVNGGSHSDAPIAFQEFMVLPVGAPNFKEALRWGAEIFHNLAKILKGRNLSTAVGDEGGFAPTFEGTEDAVETILEAIKAAGLEPGKDVFLGFDCAASEFFENGVYDYAKFEGENGKKRTSSEQVDYLEELVDKYPIITIEDGMDENDWEGWKALTDRLGNKVQLVGDDLFVTNTKILERGINEGVGNSILIKVNQIGTLTETFEAIEMAQKAGYTAVVSHRSGETEDTTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDELFETAKFKGLNAFYNLNK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RDRP_CARMS
Sequence: MGLPSLLVEGVIGCTLVGGLVAVGSAALAVRATIGVVEFNRECVRGARRIVSSGGRCLIVQSPYGNPNQGLIRGEDEEIDNVEESTPEELTQLIEVKAEVDGKEVVVSKKRVVNRHLRQRFVRSIAIEAKNHFGGDISPSKANYLSVSKFLTGKCKERHVVPAHTRDCVSAAMVLVFTPDVHEIRMMAGLASDAAYARKIAMASILNRKGWCWRLMVNPLDRARWWEMWCVVNGFDSNKPVTFPKXGGLFYLNGVETKIRRGGHPSVIEVDGQCPPRERKLYVQNAITTGYEYRVHNHSYANLRRGLLERVFYVERNKELVSCPQPEPGSFKEMGYLRRRFHRVCGNHTRISANDLVDCYQGRKRTIYENAAASLLDRAIERKDGDLKTFIKAEKFNVNLKSDPAPRVIQPRSPRYNVELGRYLKKYEHHAYKALDKIWGGPTVMKGYTTEEVAQHIWSAWNQFQTPVAIGFDMSRFDQHVSVAALEFEHSCYLACFEGDAHLANLLKMQLVNHGVGFASNGMLRYTKEGCRMIGDMNTALGNCLLACLITKHLMKIRSRLINNGDDCVLICERTDIDYVVSNLTTGWSRFGFNCIAEEPVYEMEKIRFCQMAPVFDGAGWLMVRDPLVSMSKDSHSLVHWNNETNAKQWLKSVGMCGLRIAGGVPIVQEFYQKYVETAGNVKENKNITEKSSSGFFMMADRAKRGYSAVSEMCRFSFYQAFGITPDQQIALEGEIRSLTIDTNVGPQCEAADSLWILNRKYQ
What is the function of this protein?
RNA-dependent RNA polymerase that plays an essential role in the virus replication.
What are the official names of this protein?
Probable RNA-directed RNA polymerase, Protein p88.
Protein: SPL10_ARATH
Sequence: MDCNMVSSFPWDWENLIMSNQSKTENEKKQQSTEWEFEKGEGIESIVPDFLGFEKVSSGSATSFWHTAVSKSSQSTSINSSSPEDKRCNLASQSSPGDSSSNIDFLQVKPSTALEVPIASAESDLCLKLGKRTYSEEFWGRNNNDLSAVSMNLLTPSVVARKKTKSCGQSMQVPRCQIDGCELDLSSSKDYHRKHRVCETHSKCPKVVVSGLERRFCQQCSRFHAVSEFDEKKRSCRKRLSHHNARRRKPQGVFPLNSERVFDRRQHTSMLWNGLSLNTRSEEKYTWGTTYETKPTQMESGFTLSFQRGNGSEDQLFTGSTLSFSAFQTSGGFSAGKSNIQLPDKGVGECSGGLHESHDFYSALSLLSTTSDSQGIKHTPVAEPPPIFGTFPSHFI
What is the function of this protein?
Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
What are the official names of this protein?
Squamosa promoter-binding-like protein 10.
What are the subcellular locations of this protein?
Nucleus.
Protein: SDHD_ECO5E
Sequence: MENAKMNSLIAQYPLVKDLVALKETTWFNPGTTSLAEGLPYVGLTEQDVQDAHARLSRFAPYLAKAFPETAATGGIIESELVAIPAMQKRLEKEYQQPISGQLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALEAGLLTLEDDYSKLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEQDYGVAVEEGRKAAQSDPNCFFIDDENSRTLFLGYSVAGQRLKAQFAEQGRIVDADNPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCFFAEPTHSPCMLLGVHTGLHDQISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGFYTLSDQTMYDMLGWLAQEEGIRLEPSALAGMAGPQRVCASVSYQQMHGFSAEQLRNATHLVWATGGGMVPEEEMEQYLAKGR
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: XDH_EMENI
Sequence: MAPGVLLQPSQSELEAASPPKAAASLLQLTEEWDDTIRFYLNGTKVILDSVDPEITLLEYLRGIGLTGTKLGCAEGGCGACTVVVSQINPTTKKLYHASINACIAPLVAVDGKHVITVEGIGNVKNPHAIQQRLAIGNGSQCGFCTPGIVMSLYALLRNDPKPSEHAVEEAFDGNLCRCTGYRPILDAAQSFTSPIGCGKARANGGSGCCMEEQKGTNGCCKGSSEETTEDVKHKFASPDFIEYKPDTELIFPPSLWKHELRPLAFGNKRKKWYRPVTVQQLLEIKSIHPDAKLIGGSTETQIEIKFKQMRYGASVYLGDLAELRQFAFHDNYLEIGANISLTDLESVCDQAIERYGSARGQPFAAIKKQLRYFAGRQIRNVASPAGNLATASPISDLNPVFVATNTTLVARSLDKETEIPMTQFFRGYRSTALPPDAIISSLRIPTASEKGEYLRAYKQSKRKDDDIAIVNAALRVSLSSSNDVTSVSLVFGGMAPLTVSARNAEAFLTGKKFTDPATLEGTMGALEQDFNLKFGVPGGMATYRKSLALGFFYRFYHDVLSQIEARSSDLDNSVVAEIERAISTGEKDNEASAAYQQRVLGRAGPHLSALKQATGEAQYTDDIPAQKNELYGCMVLSTKAHAKLLSVNTEAALEIPGVIDYVDHKDLPSPRANWWGAPNCDEVFFAVDKVTTAGQPIGMILANTAKAAEEGARAVKVEYEELPVILSIEEAIEAQSFFERFRYIKNGDPESAFRDADHVFEGVSRMGGQEHFYLETQACVAIPKAEDGEMEIWSSTQNPTETQSYVAQVTGVAANKIVSRVKRLGGGFGGKETRSVQLAGICATAAAKVRRPVRCMLNRDEDIATSGQRHPFYCKWKVGVTREGKLLALDADVYANGGHTQDLSGAVVERSLSHIDNVYRFPNIYVRGRICKTNTVSNTAFRGFGGPQGLFFAESIISEVADHLDLQVEQLRILNMYEPGDMTHFNQELKDWHVPLMYDQVLQESEYFERRKAVEEYNRTHKWSKRGMAIIPTKFGISFTALFLNQAGALVHIYHDGSVLVAHGGVEMGQGLHTKMTMIAAEALGVPLSDVFISETATNTVANTSSTAASASSDLNGYAIYNACTQLNERLKPYREKMPNATLKDLAHAAYFDRVNLSAQGYYRTPDIGYTWGENKGQMFFYFTQGVTAAEVEIDTLTGDWTPLRADIKMDVGRTINPSIDYGQIEGAYIQGQGLFTTEESLWHRTTGQIFTKGPGNYKIPGFRDIPQIFNVSLLKDVEWENLRTIQRSRGVGEPPLFMGSAAFFAIRDALKAARKEWGVTDVLSLVSPATPERIRVSCADPIIERARVKAEEGEKSFFVAI
What is the function of this protein?
Key enzyme in purine degradation.  Catalyzes the oxidation of hypoxanthine to xanthine.  Catalyzes the oxidation of xanthine to uric acid (By similarity).
What are the official names of this protein?
Xanthine dehydrogenase, Purine hydroxylase I.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: MIC60_PARBP
Sequence: MLRTSIATSRQLLSSPVCPKASAQWLRSSNAGRANTTTRRYYAIQQEPNGALRSSLSPSAAAVSDVSQRASNSTNTKRPNTSDLNVRSPASPSTGSTLKPETVLVAPVSPLRQGQSSPGSAAPAPEPAAAPPPSPPPPPPAPKTGRLRKFLLYLFLTTGLAYAGGVWYSLRSDNFYDFFTEYAPYGENAVIYLEERDFRNRFPNATKKNNRRAVAPRDEGAQVTIPGGSGLSWKVAEEQQEGSDISKKGPHMSAVDNNKATKDTKTVEKTKGGVTSKSPAQKEEAVMTKPAPEGVKTQPAKVAETPREPAIPAITTIDHLVLNTEDEPVVQDLVKVFNDIITVISADAPSSFSGPVAKAKEELEKIGKRILALKSDAQASAQKEINDAHASFDKSAANLIRHIDEMRAEDATKFREEFEAERERIAQSYQEKINTELQRAHEVAEQRLRNELVEQAIELNRKFLSDVKNLVEHERESRLSKLAELVSSVAELERLTAGWSDVIDINLKTQQLQVAVDAVRTTLENSNVPRPFIRELAAVKELASNDEVVSAAIDSISPVAYQRGIPSSAHLVDRFRRVATEVRKASLLPENAGITSHAASFVLNKVMLKKHGSPAGNDVESTLTRAENFLEEGNLDEAAREMNSLKGWAKLLSKDWLADVRRVLEVKQALEVIETEARLRCLQVE
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Plays a role in keeping cristae membranes connected to the inner boundary membrane.  Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
What are the official names of this protein?
MICOS complex subunit MIC60, Mitofilin.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic60 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: ILVD_BACCN
Sequence: MRSDMIKKGFDKAPHRSLLKATGLKDEDFHKPFVAICNSFIEIIPGHKHLNEFGRLVKEAVRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAAMRINIPTVFVSGGPMAAGKTSKGEVVDLSSVFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILATDSRREQLIQRAAESLKILMERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLAIAQEAGLDYDMNRIDAVSRKVPHLCKVSPASNWHMEDIDRAGGMSAILKELSRKEGVLHFDRITVTGKTLRENIADAEIQDKEVIHSLENPHSQEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHISPEAAAGGEIALLQQGDIVCIDVEERLLEVKVSDEELAKRRKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKMQNFD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: VAMP4_BOVIN
Sequence: MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAVILLLVIIILIVVKYRT
What is the function of this protein?
Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules.  May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity).
What are the official names of this protein?
Vesicle-associated membrane protein 4, VAMP-4.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles (By similarity).
Protein: UPPP_THERP
Sequence: MNVWQAAVLGIVQGTTEFLPISSSAHLIVLPWLFDWPEPGLAFNVALHLGTLSAVLAYFWRDLIQIGRAWFAGLIRLRPLEDSASRLGWAVIIGSLPAGLAGFFLNDVIDHFFHSGGGGDTAIVFTSLLLIVLGFVLWLAERYGTRWRSLGELGLRDGLVVGLAQALALLPGVSRSGSTITASLFLGFARPAAARFSFILGIPAIAGAGLLETLKLVETGLPAEQRVLFVTGVASAAITGFLAIAFLLRFLQRYSTSIFIVYRIALGLVLLLVVSFAR
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SY125_ARATH
Sequence: MNDLFSNSFKKNQAQLGDVEAGQETMNLDKFFEDVENVKDDMKGVEALYKKLQDSNEECKTVHNAKKVKELRAKMDGDVAMVLKRVKIIKQKLEALEKANANSRNVPGCGPGSSTDRTRSSVVSGLGKKLKDLMDSFQGLRARMNNEYKETVERRYFTITGEKADEQTIDNLIASGESENFLQKAIQEQGRGQILDTISEIQERHDAVKEIEKNLLELHQVFLDMAALVEAQGQQLNNIESHVAKASSFVRRGTDQLQDAREYQKSSRKWTCYAIILFIVIFILLLIPLLPHIMLMLK
What is the function of this protein?
Vesicle trafficking protein that functions in the secretory pathway.
What are the official names of this protein?
Syntaxin-125, AtSYP125.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein.
Protein: AZUP_PARDE
Sequence: ATHEVHMLNKGESGAMVFEPAFIRAEPGDVINFIPTDKSHNVEAIKEILPEGVETFKSKINEAYALTVTEPGLYGVKCTPHFGMGMVGLVQVGDAPENLDAAQTAKMPKKARERMDAELAQVN
What is the function of this protein?
This soluble electron transfer copper protein is required for the inactivation of copper-containing nitrite reductase in the presence of oxygen.
What are the official names of this protein?
Pseudoazurin.
What are the subcellular locations of this protein?
Periplasm.
Protein: PSUG_BREBN
Sequence: MKQYLTFTEEVRHALENNLPVVALETTIISHGMPYPQNIEMAKEVEQIIRDNGAVPATIGIMDGKIKIGLTDSELEEFATNKNVAKVSRRDFAYILASGKIGATTVAATMIAAEMAGIHMFATGGIGGVHREGEITWDVSADLTELAQTDVAVVCAGAKSILDIGRTLEYLETQGVPVVGYRTDEFPSFFARKSGFGVDMRIDTPEEVGKMMNTKWDLGLKGGMIIANPVPESDALNHEEIEAVIQKALAEAKENNIAGKQVTPFMLDKVKKLTEGKSLATNIALVKHNAEVAAKIAVAYQKEANQGK
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: OGT_HAEIN
Sequence: MTALYYTYYPSPVGRLLILSDGESITHIDFEKEQYAPNPKWHKQDELPVFQKVRLAFERYFNGEVECFSNIPLKPEGTAFQQAIWQALREIDYGELSTYGELALRINNPKAVRAVGGAVGSNPISIIIPCHRILGKDRTLTGFGGGLEAKRFLLQLEKIPYIDKGTENTKPRFFKKYHE
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOF_EXIS2
Sequence: MGFEHLRTELEEMKQAGTFRELVALESAQHNRVTVDGKELIQLSSNNYLGLAAHPRLAKRAADAALEFGAGTGSVRTIAGTLEMHQAFERELATFKHTEAALVFQSGFATNLGVLSALLGPEDVVISDALNHASIIDGIRLTKAKRRIYNHVDLADLEAALQETQDARTRLVVTDGVFSMDGNIAPLPEIVELAEKYDALVMVDDAHASGVLGKSGRGTVNHFGLDGRVALQVGTLSKAIGVLGGYVACEQHVKDYLIHKGRPFLFSTSHPPAVVEANREALRVMEEETELFDRLWENTEFFKHGLRELGFNIGTSTTPITPVIVGDEALCHQLSDRLRQHGVFAQGIAFPTVAKGKARVRTIVTAEHTREDLEQALEAFKQVGQELELI
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase, Alpha-oxoamine synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.