PharMolix/UniProtQA huggingface dataset:
Protein: PRIO_CAPHI
Sequence: MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSPPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: MNMA_BRUC2
Sequence: MSLNSLDLPGKSEDTRVVVAMSGGVDSSVVAGILKREGYDVVGVTLQLYDHGAAVHRAGSCCAGQDIEDARRVSESLGIPHYVLDYEARFREAVIDPFANSYVSGETPIPCVSCNQTVKFADLLQTARDLGADALATGHYIRSRANGAHRALYRPVDTDRDQSYFLFATTQEQIDYLRFPLGHLPKAQVREIAEELGLTVAKKQDSQDICFVPQGKYSDIISRLKPEAANPGDIVHIDGRTLGRHDGIVHYTVGQRRGIGVATGEALYVVHLDAANARVIVGPREALETHKVFLRDVNWLGDTPIADLPKSGMEVFAKVRSTRPPRPAVLRHADGQTWVELVDGESGIAPGQACVLYSDDSNAARVFGGGFIGRSEREPQAEEMLRRLMANADKASAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_MYCVP
Sequence: MYVRHLALTDFRSWARVELELEPGRTVFVGSNGFGKTNLIEALWYSATLGSHRVASDAPLIRAGAERAVVSTIVVNDGRELAVDLDITSGRANKARLNRSPVRSAREILGVLRAVLFAPEDLALVRGDPGERRRYLDELATTRRPRIAAVRADYDKVVRQRTALLKTASGARYRGDRGALETLDVWNGHLASHGAQLISARVQLVNELAPEVEKAYQLLAPGSRPAAIRYRSGVDVVEAEAAAGNSDEEMFEAALLDALSRRRDAELERGVCLVGPHRDDLELRLGDQVAKGFASHGESWSMALALRLAAYELLRVEGSDPVLLLDDVFAELDSARRQALAQVAATAEQVLVTAAVEEDIPAEWDARRIGITMQDSDGGRISVVRT
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLB_ALIF1
Sequence: MLKRWILTLFVVCLGFSQVAKAELELVITEGIDSARPIGIVPFKWHGEGKLPQDISAIISSDLQRSGKFSPVATNKMPQTPYKDSDINYEAWTKMGVDAIVTGEVKLNAQGKYEVTYKLIDVVRGQLTKGQSKALDESGKLVLTRDHILVNKVASLSTKQLRKYAHRISDVVYEKLTGERGAFLTRIAYVVVNDKAQYPYQLRIADYDGYNERLVLKSKQPIMSPAWSPDGKKLAYVSFENRKSQIFIMNIYTGKRELIASYPRHNGAPRFSHDGDKLAIVLSKSGSLQIYVVDLKTKKMSQITRGRANNTEPFWAPDNKSLIFTSDRGGKPQIYRVNLGDGSTKRLTWQGSQNLGGQITPDGKYIVMVNRSETGFNLAKQDLETGAVQVLTKTLLDESPSIAPNGGMVIYSSIYRKQNVLSMVSIDGRFKARLPATNGRVRAPAWSPFL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GAT27_ARATH
Sequence: MGKQGPCYHCGVTSTPLWRNGPPEKPVLCNACGSRWRTKGSLVNYTPLHARAEGDETEIEDHRTQTVMIKGMSLNKKIPKRKPYQENFTVKRANLEFHTGFKRKALDEEASNRSSSGSVVSNSESCAQSNAWDSTFPCKRRTCVGRPKAASSVEKLTKDLYTILQEQQSSCLSGTSEEDLLFENETPMLLGHGSVLMRDPHSGAREEESEASSLLVESSKSSSVHSVKFGGKAMKQEQVKRSKSQVLGRHSSLLCSIDLKDVFNFDEFIENFTEEEQQKLMKLLPQVDSVDRPDSLRSMFESSQFKENLSLFQQLVADGVFETNSSYAKLEDIKTLAKLALSDPNKSHLLESYYMLKRREIEDCVTTTSRVSSLSPSNNNSLVTIERPCESLNQNFSETRGVMRSPKEVMKIRSKHTEENLENSVSSFKPVSCGGPLVFSYEDNDISDQDLLLDVPSNGSFPQAELLNMI
What is the function of this protein?
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
What are the official names of this protein?
GATA transcription factor 27.
What is the protein family that this protein belongs to?
Belongs to the type IV zinc-finger family. Class D subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPA_KINRD
Sequence: MPTATAAQPLRPFGTVLSAVVTPFTASGAVDLDAAAALAVHLVEHGHDGLVVSGTTGESPTTSDEEKDRLLRAVLDAVGDRVHVLAGVGTNDTAHTLELARAAEKAGAHGLLVVTPYYNKPPQAALAHHFTTVADGTGLPVMLYDIPGRSGVPIETETLVRVAEHERIVAVKDAKGDSWGTSWVLARTELAYYSGDDAVNLPLLAQGASGIVSVVSHVAGREYAAMVAAVDAGDLVTARAIHTRLLPAVRGIMTRTQGVVAVKAALELTGVLSGRAVRPPLLPATPEEVAALAADLALAGLAPAPLDA
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGT2_RAT
Sequence: MSLAWRTLQKAFYLETSLRILQMRPSLSCASRIYVPKLTLHTKHNMPPCDFSPEKYQSLAYNHVLEIHKQHLSPVNTAYFQKPLLLHQGHMEWLFDSEGNRYLDFFSGIVTVGVGHCHPKVTAVAKKQMDRLWHTSSVFFHSPMHEYAERLSALLPEPLKVIFLVNSGSEANDLAMVMARAYSNHTDIISFRGAYHGCSPYTLGLTNVGIYKMKVPSTIACQSTMCPDVFRGPWGGSHCRDSPVQTVRKCSCAPDGCQAKERYIEQFKDTLNTSVATSIAGFFAEPIQGVNGVVQYPKEFLKEAFALVRERGGVCIADEVQTGFGRLGSHFWGFQTHDTMPDIVTMAKGIGNGFPMAAVVTTPEIASSLAKHLHHFSTFGGSPLACAIGSAVLEVIEEENLQRNSQEVGTYMLLKFAKLRDEFDIVGDVRGKGLMVGIEMVQDKISRQPLPKTEVNQIHEDCKDMGLLVGRGGNFSQTFRIAPPMRVTKLEVDFAFEVFRSALTQHMERRAK
What is the function of this protein?
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV).  ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity).
What are the official names of this protein?
Alanine--glyoxylate aminotransferase 2, mitochondrial, AGT 2, (R)-3-amino-2-methylpropionate--pyruvate transaminase, Beta-ALAAT II, Beta-alanine-pyruvate aminotransferase, D-AIBAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HAD1_PSEUC
Sequence: MDPIRACVFDAYGTLLDVNTAVMKHAHDIGGCAEELSSLWRQRQLEYSWTRTLMGRYADFWQLTTEALDFALESFGLLERTDLKNRLLDAYHELSAYPDAVGTLGALKAAGFTTAILSNGNNEMLRGALRAGNLTEALDQCISVDEIKIYKPDPRVYQFACDRLDVRPSEVCFVSSNAWDIGGAGAFGFNTVRINRINKPQEYSFAPQRHQLSSLSELPQLLLRLTQ
What is the function of this protein?
Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.  Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-2.  Active with 2-halogenated carboxylic acids and converts only the S-isomer (or L-isomer) of 2-chloropropionic acid with inversion of configuration to produce R-lactate (or D-isomer).
What are the official names of this protein?
(S)-2-haloacid dehalogenase 1, 2-haloalkanoic acid dehalogenase I, DEHCI, Halocarboxylic acid halidohydrolase I, L-2-haloacid dehalogenase I.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
Protein: TGT_DESAP
Sequence: MGILFEVLKQDSRTRARLGRLTTPHGVVETPVFMPVGTQATVKTMTPEEVRDLGARIILSNTYHLYLRPGHELVREAGGLHRFMHWNGPILTDSGGFQVFSLAPLRKLSDEGVEFRSHIDGSRHFFTPEKVVAVQEALGSDIAMVLDECAPYPCSYKDARTATERTTRWAARARAAWNSDGATALFGIIQGSVYRDLREESTRALVDLDFPGYGIGGLSVGEPKPLMYEALEWVIPLIPEDRPRYLMGVGSPDCLFEGIARGVDMFDCVLPTRMARHGAVFTHTGRLVVRNAPNARDFGPLDPGCTCYTCRHFSRAYVHHLLRAGEVLGIRLTTIHNLHFLLDLARRIREAIAEDRFHSLKEQFLAACLTPA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RL27_EHRRG
Sequence: MATKKSGGSSSNGRDSRGRRLGVKKFGSEKVIPGNIIIRQRGTKYHPGRNVGIGKDHTIFSKVSGVVYFRKGALNKTFVDVLEVNSAS
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PP1B_RABIT
Sequence: MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR
What is the function of this protein?
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets.  Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.  Involved in regulation of ionic conductances and long-term synaptic plasticity.  Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.  In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation.  May dephosphorylate CSNK1D and CSNK1E (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-beta catalytic subunit, PP-1B.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Protein: DEOC_ACTP7
Sequence: MSLKDSAKIALSLMDLTTLNDNDTDEKVITLCQQGKTEFGTPAAVCVYPRFVPIARKALKAQGTEQVKIATVTNFPHGNDDIDIAVAETKAAVAYGADEVDVVFPYKALMAGNEQIGFELVQQCKAVCQASNVLLKVIIETGELKTAELIRKASEISIKAGADFIKTSTGKVPVNATLESARIMLETIRDLNVADRVGFKAAGGVKTAEEAAQYLALAQEILGHDWVNSDHFRFGASSLLTNLLAALNGQANQKVSGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPZ_VIBAL
Sequence: MVAALARPGRELARQLLMIQSGAVIFVAAGMAVAINPDWGFSALIGGGIFVVANAVFALCAFMFSGARAAKRIAASFYTGEVLKILITVALFYVAYMYMQVELVPLKLTYLLVLGINICAPVLFINNKK
What is the function of this protein?
A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.
What are the official names of this protein?
ATP synthase protein I.
What is the protein family that this protein belongs to?
Belongs to the bacterial AtpI family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PHS_MICAN
Sequence: MTELAQQKCQPYQSGSSPITAEEITALQAKIPDWNLLEYEGIPRLQKLYKFANFQGAIAFTNAVGEAAEKEGHHPALLTEWGKVTVSWWTHDVGGLHQNDFIMAARTDDIYRQQNA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: SERB_ALBFT
Sequence: MHPTAIAPGLIIQGFAPPLRLSDFKLIAFDMDSTLINIECVDEIADAVGRKREVAAITEAAMRGEITDYKESLRQRVALLQGVTEVQMNQIYQERMQFNPGAAELVAACKAAGLKVLLVSGGFTHFTDRVAQRLGIDYTRSNVLQIENGVLTGRMVDQPWGDICDGAEKRKMLLETCALLGIAPKQAIAVGDGANDLPMMREAGLSVAFHAKSAVRELANVSIESGGLDRLLELFQP
What is the function of this protein?
Catalyzes the dephosphorylation of phosphoserine (P-Ser) in vitro.  Also catalyzes the dephosphorylation of phosphothreonine (P-Thr) in vitro.
What are the official names of this protein?
Phosphoserine phosphatase, PSP, PSPase, O-phosphoserine phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. SerB family.
Protein: PHNC_LACLA
Sequence: MIKFENVSKIYPNGTKGLTDVNLQINQGEFVAIIGTSGAGKSTLIRCVNGLNDITSGSLIVNDTEVSKLKGKELRKFRRHVGMIFQSYNLVPRVTVLKNVMFARVPDMSLFKVIFGLFSKEDKLVALDSLNKVGILDKAYIRADQLSGGQQQRVSLARALSQESEILLADEPVSALDPVTAKEVMDDFKRINEEFNKTILLNIHHVELALEYASRIIAVKKGKIVYDGPSQEVTKEILDEVYRKEA
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: AROD_STRP6
Sequence: MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAVAPAIFEKFAGKEIIFTLRTVQEGGNITLSSQEYVDIIKEINAIYNPDYIDFEYFTHKSVFQEMLDFPNLILSYHNFEETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNYTRGFKTLNPEQEFATISMGKLGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRIIEVLEMDISN
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: RBFA_GLUDA
Sequence: MNTAGPAGKLAGHAASGPTQRQLRVGEEVRRMLADLFARTEFRDPELVDVRITVTEVRISPDLKHATAFVARLGRSDVETLLPALKRVAPFLRSRLSTGLRLRGVPEIHFQPDTALDYAMEVDALLRQPDVARDLD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STUA_GIBM7
Sequence: MNQGHPQPDMYYSPHYSTPQYGYGYSTNGAPTTAVSTPMPAPQNVLPVPSALSNQGAMQQPGYSNSSNNGAFDTTGQHNPPGMKPRVTATLWEDEGSLCFQVEARGICVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKVRHVVKIGPMHLKGVWIPYDRALDFANKEKITELLFPLFVHNIGALLYHPSNSNRTSQVMAAAERRKHEGLGGQRPPAPNALPSIGQHHPMMPGLPTGGYVPQSLANGPQSLASTPQPLANGSQPPMPNGGGMLKRGREEEEDLHRPVSNGHDPMSNMHAMSNGYPQQPPLANVHQPPMQNGGDMLKRGREEDDEVHRSAHNAHDTMNNMPGSMPGMSNAYAQPLPNVHHQPLANGDGGMLKRGRDEDDDHRSSPNGHDSAGNFEAKRRKTITSNDSMVSPGGFYTLHNGYGQPGVMNGMSPYKRRDDEAETPRPGPNVHDHLNNFDLKRHKTMETSVPAPQYDAMNRPHSSIGTSPSYAPAPVYDNLARPASTVAASPSYPSAPVYDTAARPPSAISAPRRQQSFG
What is the function of this protein?
Transcription factor that regulates asexual reproduction (PubMed:24161731).  Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (By similarity).
What are the official names of this protein?
Cell pattern formation-associated protein StuA, Stunted protein A.
What is the protein family that this protein belongs to?
Belongs to the EFG1/PHD1/stuA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SCX2_TITOB
Sequence: MIRFVLFISCFFLIGTVVECNKDGYLMEGDGCKMGCLTRKASYCVDQCKEVGGKDGYCYAWLSCYCYNMPDSVEIWDSKNNKCGKGK
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.  Affects the tetrodotoxin-sensitive sodium current permeability of F-11 rat neuroblastoma cells.  Produces a dose dependent increase in amplitude and duration of the current.
What are the official names of this protein?
Alpha-toxin To2, Alpha-toxin Tc48a, Alpha-toxin To48a, PT-alpha' NaTx11.1.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: KAD_STAAR
Sequence: MNIILMGLPGAGKGTQASEIVKKFPIPHISTGDMFRKAIKEETELGKEAKSYMDRGELVPDEVTVGIVKERISEDDAKKGFLLDGFPRTIEQAEALNNIMSELDRNIDAVINIEVPEEELMNRLTGRRICESCGTTYHLVFNPPKVEGICDIDGGKLYQREDDNPETVANRLSVNIKQSKPILDFYDQKGVLKNIDGSKDISDVTKDVIDILDHL
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAC_ORYSI
Sequence: MSHSVKIYDTCIGCTQCVRACPTDVLEMIPWDGCKAKQIASAPRTEDCVGCKRCESACPTDFLSVRVYLGPETTRSMALSY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: PYRF_RHIE6
Sequence: MDARERLIVGLDVPTIGEAEKLVSTLGDDILFYKIGYQLVFAGGLEFARDLAASGKKIFLDMKLLDIDNTVASGVENIARMGMSMLTLHAYPKAMRAAVEAAAGSGLCLLGVTVLTSMDAEDLAEAGYNQDPHSLVLRRAEQARAAGMGGIVCSAAEAAEVREVLGPDMAIVTPGIRPTGSDHGDQKRVMTPFDALKAGATHLVVARPIVKAPDPRHAARAVLNEMVAARWPANR
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: RL12_PRUAR
Sequence: MPPKFDPSQVVDVYVRVTGGEVGAASSLAPKIGPLGLSPKKIGEDIAKETANDWKGLRVTVKLTVQNRQAKVSVVPSAAALVIKALKEPERDRKKTKNIKHSGHISLDDVIEIAKIMKHRSMAKELAGTVKEILRTCVSVGCTVDGKDPKDLQQEIADGDVEIPLD
What is the function of this protein?
This protein binds directly to 26S ribosomal RNA.
What are the official names of this protein?
60S ribosomal protein L12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: T3MO_BPP1
Sequence: MKKETIFSEVETANSKQLAVLKANFPQCFDKNGAFIQEKLLEIIRASEVELSKESYSLNWLGKSYARLLANLPPKTLLAEDKTHNQQEENKNSQNLLIKGDNLEVLKHMVNAYAEKVNMIYIDPPYNTGKDGFVYNDDRKFTPEQLSELAGIELDEANRILEFTTKGSSSHSAWLTFIYPRLYIARELLKEDGVIFISIDDNEDKQLGLLCDEVFGQGNFVAKLPTIMNLKGNHDNFGFSDTHEYIYVYAKNKDVCSLGQFDIDESEVEKEWDEDEYGLFKRADTLKRTGQDASRKSRPKGWFPVFINSENKVYVTDDDKPLNEDDYVLYPVSPTGEELSWSWGKKKINDEFYNLIVIDIKDGKNIYKKQRPALGELPTKKPKSIWYKPEYSTSTATTELKNLLGAKLFEGPKPVPLITDLVKIGTKKDSLVLDFFAGSGTTAEAVAYLNEKDSGCRNFICIQKDEVINKTKNAYSLGYRSIFEITKKRIQEVFKKSTTTSDNAAKIGFKVIHTIDDFRAKVESELTLTNHTFFDDAVLTPEQYDALLTTWCVYDGSLLTTPIEDVDLSGYTAHFCNGRLYLIAPNFTSEALKALLQKLDSDEDFAPNKVVFYGCNFESAKQRELNEALKSYANKKSIELDLVVRN
What is the function of this protein?
A beta subtype methylase that binds the system-specific DNA recognition site 5'-AGACC-3' and methylates A-3 (of only 1 strand as the other does not have an A residue).  DNA restriction requires both the Res and Mod subunits.
What are the official names of this protein?
Type III restriction-modification enzyme EcoPI Mod subunit, M.EcoPI, EcoPI methyltransferase, Type III methyltransferase M.EcoPI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: RL10_BRUSI
Sequence: MDRAEKREFVAWLNGAFKESGSVVVAHYTGLTVAQMSDLRSKMRDAGGAVKVAKNRLAKIALQGTESEGIADLFTGQTVVAYANDPITAPKVAVEFAKANDKLVILGGAMGATTLNADGVKSLASLPSLDELRAKLVGMIQTPAQRLAVLTSAPAGQIARVIGAHARKNEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.