PharMolix/UniProtQA huggingface dataset:
Protein: CLCN3_MOUSE
Sequence: MESEQLFHRGYYRNSYNSITSASSDEELLDGAGAIMDFQTSEDDNLLDGDTAAGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKDILRHMAQTANQDPASIMFN
What is the function of this protein?
Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons.
What are the official names of this protein?
H(+)/Cl(-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 1]: Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Early endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane; Multi-pass membrane protein.
Protein: MINE_PROM2
Sequence: MMTLRDLINKLLGRETSSANTARERLQLVLAHDRVDMSSLTTDLLDKMRKEILDVVAKYVEIDFEEVAVSLETEDRMTALVANLPIKRTISGEIKFKKTDKANKDIKK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: PNP_STAA2
Sequence: MSQEKKVFKTEWAGRSLTIETGQLAKQANGAVLVRYGDTVVLSTATASKEPRDGDFFPLTVNYEEKMYAAGKIPGGFKKREGRPGDDATLTARLIDRPIRPLFPKGYKHDVQIMNMVLSADPDCSPQMAAMIGSSMALSVSDIPFQGPIAGVNVGYIDGKYIINPTVEEKEVSRLDLEVAGHKDAVNMVEAGASEITEQEMLEAIFFGHEEIQRLVDFQQQIVDHIQPVKQEFIPAERDEALVERVKSLTEEKGLKETVLTFDKQQRDENLDNLKEEIVNEFIDEEDPENELLIKEVYAILNELVKEEVRRLIADEKIRPDGRKPDEIRPLDSEVGILPRTHGSGLFTRGQTQALSVLTLGALGDYQLIDGLGPEEEKRFMHHYNFPNFSVGETGPVRAPGRREIGHGALGERALKYIIPDTADFPYTIRIVSEVLESNGSSSQASICGSTLALMDAGVPIKAPVAGIAMGLVTREDSYTILTDIQGMEDALGDMDFKVAGTKEGITAIQMDIKIDGLTREIIEEALEQARRGRLEIMNHMLQTIDQPRTELSAYAPKVVTMTIKPDKIRDVIGPGGKKINEIIDETGVKLDIEQDGTIFIGAVDQAMINRAREIIEEITREAEVGQTYQATVKRIEKYGAFVGLFPGKDALLHISQISKNRIEKVEDVLKIGDTIEVKITEIDKQGRVNASHRALEE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FYV1_YEAST
Sequence: MSLYQSIVFIARNVVNSITRILHDHPTNSSLITQTYFITPNHSGKNISFHLFHDFKYCSADTRHYSQLIIFPVKENSRPTQVSRPLGGRPHESVFLPKFTRTQNSYCLTRLDRMGFPPPRKASTIMHFFQDDRTVMCSPKDGIPVSSFHIMICFLERRKGN
What are the official names of this protein?
Putative uncharacterized protein FYV1.
Protein: RPA2_HUMAN
Sequence: MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQAIPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINWAVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQVLNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMYYKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors.  Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit.  Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
What are the official names of this protein?
DNA-directed RNA polymerase I subunit RPA2, RNA polymerase I subunit 2, DNA-directed RNA polymerase I 135 kDa polypeptide, RPA135.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome.
Protein: RL24_PASMU
Sequence: MAAKIRQNDEVIVLAGKSKGKRGKVTQVLPNGKVIVEGVNIITKHEKPVPALGKEGGLVKKEAAIDVSNVAIFNPKTNKADRVGFRFEDGKKVRFFKSNNEII
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: YIDC_SHELP
Sequence: MESQRNILLIGLLFVSFLLWQQWQTDKNPQPVATESSVVASTVTDAHSADVPDADAALPEAVAASKELISVTTDQLTLKINPVGGDIVYSALVGHKLEQDKEEPFVLLQQTKDIYYISQSGLIGRNGIDSSTKGRAHFSSQSQAYTLADGQDTLEIPLTYVADNGVTYTKVFTLHRGKFDVGVEYRINNTSAEQLQVQMYGQIKHSIKKSESSMMMPTYRGAAFSTADTRYEKYSFEDMADKNLDKKTLGGWAAMLQHYFVSAWVPPANDQNTIFSSVSAGGLANIGFRGAVYDVAPGTQQTISAQFYVGPKDQEALSAISESLNLVVDYGFLWWLAIPIHWLLMFYQSFVGNWGVAIILITLTVRGMLYPLTKAQYTSMAKMRNLQPKLQDMKERFGDDRQKMGQAMMELYKKEKVNPMGGCLPILLQMPIFIALYWVLLESYELRHAPFMLWITDLSVQDPYYVLPLLMGVSMFLMQKMQPMAPTMDPMQQKMMQWMPVIFTVFFLWFPAGLVLYWLVGNLVAITQQKIIYAGLEKKGLK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRAE2_ECOLX
Sequence: MEHGARLSTSRVMAIAFIFMSVLIVLSLSVNVIQGVNNYRLQNEQRTAVTPMGFNVPFAVSQNSADASYLQQMALSFIALRLNVSSETVDASHQALLQYIRPGAQNQMKVILAEEAKRIKNDNVNSAFFQTSVRVWPQYGRVEIHGVLKTWIGDSKPFTDIKHYILILKRENGVTWLDNFGETDDEKK
What is the function of this protein?
Involved in F pilus assembly.
What are the official names of this protein?
Protein TraE.
What is the protein family that this protein belongs to?
Belongs to the TraE family.
Protein: PARE_RICBR
Sequence: MSDLFSFNKEKKTKIINNTYSAKDIEVLEGLEPVRKRPGMYIGGTDLNAMHHLVSEVLDNSMDEAVAGFASIITIKMHQDHSITISDNGRGIPIDNHPKFPNKSALEVILTTLHSGGKFSSNVYQTAGGLHGVGVSVVNALAEHLEIKVYKQGKLYKQSYAKGEKLTELICEEAPKRLKGTSINFIPDPEIFGDKIHFNPKKVYELARSKAYLYRGVTIEWECEIEASSDVPKKALINFPNGLKDYLSSKITPDDLITTEIFSGNVESEQDGIKLEWAICWQNNDSSAFIQSYCNTVPTPLGGTHEQGLKSALLRGLKAYGEMVGNKKTANLAIEDILETASVVLSIFIAEPTFQGQTKEKLVSQGVSKPAENIIKDHFDHFLSSNKTIANNLLEHFIAIAEFRLNKKNEKTISRKNATQKLRLPGKLADCTRTSPEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLEKIVNNQAIQDLEIALACGSMKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPKLVEDGHLYLAKPPLYRLTQSNKTYYANDEEEKAKLTDKLSKSSKAKIEVGRFKGLGEMMPMQLKETTMHPEKRSLLKVTLEDFQNVDKIVDDLMGKKPEKRFQFIYEQALVKMDKIINELDI
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA.  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit B, Topoisomerase IV subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Protein: MASP2_POLPI
Sequence: INWLKLGKMVIDAL
What is the function of this protein?
Antimicrobial peptide (PubMed:19463874, PubMed:30974767).  Is active against both Gram-negative and -positive bacteria (Staphylococcus aureus (MIC=2 uM), Mycobacterium abscessus subsp.  massiliense, S. aureus (EC(50)=1. 83 uM), Escherichia coli (MIC=5 uM), Pseudomonas aeruginosa (MIC=38 uM), Bacillus cereus (MIC=5 uM), and the multidrug-resistant bacterium A. baumannii), and fungi (Candida albicans (EC(50)=12. 9 uM, EC(90)=15. 3 uM) and Cryptococcus neoformans (EC(50)=11 uM, EC(90)=22. 7 uM)) (By similarity) (PubMed:19463874, PubMed:30974767).  Inhibits biofilm formation of A. baumannii and Staphylococcus spp.  bacteria (PubMed:30974767).  Mycobacteria cell shape and cell wall integrity are not altered after exposure to the peptide (6. 25 uM) (By similarity).  Has low hemolytic activity (MIC=50 uM) (PubMed:15150833, PubMed:19463874) (By similarity).  Is also cytotoxic to mouse peritoneal macrophages (EC(50)=13. 19 uM) (By similarity).  Also causes moderate mast cell degranulation (ED(50)=80 uM) and exhibits chemotactic activity for polymorphonucleated leukocytes (PMNL) (PubMed:15150833, PubMed:19463874).  Shows antibacterial activity against multidrug-resistant A. baumannii adherence and biofilm formation on vascular stents, preventing its formation and treating mature biofilm (PubMed:30974767).  In vivo, shows antistaphylococcal activity (S. aureus) with a decline bacterial load after 6 days of topical treatment (By similarity).
What are the official names of this protein?
Venom protein 13a, VP13a, Polybia-MP-II, Polybia-MPII.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Mastoparan subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: CDT1_ECHCC
Sequence: MYNAPPPQDMSYYDHCQRRHEEKGCLYACIFTALCCFCCYETCECCLDCLCCCCN
What is the function of this protein?
Confers resistance to heavy metal ions (e. g.  cadmium (CdCl(2)) and copper (CuCl(2))) by chelating them at the plasma membrane of root cells, thus stopping their entry and reducing their accumulation.
What are the official names of this protein?
Protein CADMIUM TOLERANCE 1, Cd tolerant 1, EcCDT1.
What is the protein family that this protein belongs to?
Belongs to the CYSTM1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Secreted, cell wall.
Protein: NHAB_HAEI8
Sequence: MTNIQAFMKNFLGASPEWYKLAIVVFLIINPIVFFFISPFIAGWLLVAEFIFTLAMALKCYPLQPGGLLAIEAIIIGMTNAKHVKAEIMANFEVILLLIFMVAGIFFMKQLLLYVFTKLLVKIRSKIALSIAFCFSAAFLSAFLDALTVVAVIISVAMGFYGVYHKVASGNNLIDAVDISDDRKIIEQQHEILEKFRAFLRSLMMHAGVGTALGGVMTVVGEPQNLIIAEQAKWNFMEFFLRMAPVTIPVFICGLLTCFLVEKFKLFGYGEKLPDEVWKVLSDLDRTNSEKMSKQDKIKLGMQALIAIWLILGLAFHLAAVGLIGLSIIIFATSFTGVTDEHTIGKAFQESLPFTALLVVFFSVVAVIIDQKLFSPIIHFVLSAEENTQLALFYLFNGLLSSISDNVFVATVYINEAKAALTNGVIAPHQFELLSVAINTGTNLPSVATPNGQAAFLFLLTSSISPLIRLSYGRMVYMALPYTIVLSIIGLLAIEFILPAATIWLASLGLILPI
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NEP_I02A3
Sequence: MDSNTVSSFQDILMRMSKMQLGSSSEDLNGMITQFESLKLYRDSLGEAVMRVGDLHSLQSRNGKWREQLSQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: NAGS_YEAS7
Sequence: MWRRIFAHGLKYDQPNASSKNLILSVLNTTATKREAKDYLSKYTNDSGQHNHCLFFIRDLHKVAPAILSQFSSVIKRLGMLGLRPMFVIPPSPTHVNIQAELLDSIVTEADLKPLHFKEGLTKSRTGLYHSVFSQESRFFDIGNSNFIPIVKPYVYNEETASEFMTKDVVKFMDCLCQGNIPHIDKFFILNNAGGIPSGERNDNAHVFINLSQELEHLSSSLSHNISTLTKREPRSQNLLHRMEVYVKKDEISSLECEYHDHLENLLLMDKVLSNLAATATGLITTVKAAALSSDRKNPLVYNLLTDRSLISSSLPRFKKKDGEIDSPANMFDDHAWYELPSQQVNAAPSNSDAVLVTTVLKKGVHIKTYDYKTLTQFNSIGLPKEFHVSEKGAKPSNNSPKLDINKFKSIIDQSFKRSLDLHDYIKRINGKIATIIVIGDYEGIAILTYEGSEENSFVYLDKFAVLPHLKGSLGISDIIFNLMFKKFPNEILWRSRKDNVVNKWYFQRSVAVLDLSIDLDPEHCDEKQSQFKLFYYGNPQYAKRALRDKKRLREFMRSVRDIKPSWENEKNIS
What is the function of this protein?
N-acetylglutamate synthase involved in arginine biosynthesis.
What are the official names of this protein?
Amino-acid acetyltransferase, mitochondrial, Arginine-requiring protein 2, Glutamate N-acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FOLD_SERP5
Sequence: MSAKIIDGKTIAQQVRNEVAEQVKQRLAAGKRAPGLAVVLVGENPASQIYVASKRRACDEVGFLSRSYDLPATTSEAELLALIDRLNADGEIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRSPKLRPCTPRGIVTLLERYNIDTYGLNAVVVGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKPGAIVVDVGINRLESGKVVGDVEFDAASERAAYITPVPGGVGPMTVATLIQNTLQACEVYHDVQPK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: LEU11_LEPIN
Sequence: MDLKDYVRIFDTTLRDGEQCPGAAMTENEKLEIASQLATMKVDIIEAGFPVSSPVQFQAVERIARETEGPMIAALARAMKADIEAASKALQPAKKRRIHTFIASSPIHMKYKLGKEPKEVLKMAVEAVTLCRQFVDDVEFSPEDATRSEPEFLRELCEAVIAAGATTINIPDTVGYTTPAEYGGLFKFLLSNVRGAEKIIFSAHCHNDLGLATANSLAAVQNGARQIECTINGIGERAGNTAMEEVVMAMRTRKDTFGIQTQIKTEEIARASYLVKTITGMLVQPNKAIVGANAFAHESGIHQDGVIKHRETYEIMKPETVGLSSNRMVLGRHSGRAGFKDRIVKLGFSPQVEELEAAYQRFLEIADRKKEIYDEDIRALFSEEARKSTGDRFQLEGFTVSTGTKSTPTAGVRILIDGHVREESATGDGPVDAIYKAIQKTTGMDPEVSRLVISPVTEGQDAMAEASVTLEYKGDRVVGKGSSTDIIEACSRAYISALNRL
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (PubMed:15292141).  Has very low alpha-isopropylmalate synthase activity, does not have citramalate synthase activity (PubMed:15292141).
What are the official names of this protein?
2-isopropylmalate synthase 1, Alpha-IPM synthase 1, Alpha-isopropylmalate synthase 1.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: ISPD_XANOR
Sequence: MTGSIWAGSIWAIVPAAGRGTRFGGPLPKQYLQAGGQPLMAYTLMALAAHPALAGIVVAIAPDDADWPGWTAVQSKPVLTCLGGATRAASVLAGVLALPESVRADDFVLVHDAARPNLALADLDRLLEIGRGDPVGAILAAPVRDTLKRAGDDGGIDGTEPRERLWRALTPQLFRRHQLIRGLTEASAAGVDVTDEAMAMERMGLRPLLVEGAEDNFKVTTPADLARFEFELARRGIAVDADALEAPAVNAQSNARNVATQLATVSYGNDAT
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: RECF_TRIL1
Sequence: MFLKQVWLEQYRNIQKACIQPARHLTVLYGRNGQGKTNFLESLYLLGNARPFRAAKVPDLISHGSRSAAVRGLVLAAGVESTIVLHVENSTRRVTIDDKAVHRAADLHGKLAVVVFSPDDTAMVKLGPETRRRYLDRSLYASDAAFLSDYHTYYRILKQRNALLKTNQQAGLDLWTEQLATAGIRLMQHRQHYTSRLNQLLQQKYQQIAGEQEKVSVVYQPDVICTAEENGTELLLNVFRNQHEQDLRYKSTGRGPHRDDLLFSIGDRPLKSFGSQGQQRSFVLALKMAELDHLQETFGEMPLLLLDDIASELDRERMTNLLSYVRQREVQVLITTTDVTPFLPVLQQDSKLFRVEEGRLTYEGNGTP
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_BACC3
Sequence: MADVLERVTKIIVDRLGVEETEVVPAASFKEDLGADSLDVVELVMQLEDEFEMEISDEDAEKIATVGDAVTYIESHL
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA2_METCA
Sequence: MNAGSENSTPRISEPASPLAQAVHIGDYRPRLRIGEYGTVASVGDGIAWVTGLPSAAMDDVLMFEDGSWAVVFALTKKRIGAVLLHQSENLTAGTPARLAGRTLDVPVGETLLGRVIDPIGNPLDGGRPLETRNRRPLDSPSPPIIARDFVQQPLYTGTRLVDTLVPIGKGQRQLIIGDEGTGRSSLAIDAVLNQKGREVRCVYVLIGQKRSTVVGTIELLRNYGALAYTTVVVGEAGSLPGLKYLAPFAGCAIAEDWMARGHDTLVVYDDLSTHAQTYRELSLLLRRPPGREAYPGDIFYLHARLLERATALNPANGGGSMTALPIVETRLGEIEAYIPTNLISITDGQIYLDSDLFAAGFKPAIDVTRSVSRIGGKAQHPRIKEEAGRMKLDYLQFLELEIFTRFGARLESGMEARIRRGRLLREILRQERLQPLPPEFQLAWMTAYNEGLLDAMPPGSVQHALNELNSALRNGSPPLEASRTDWLTWLRQNLPEPARGEA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 2, ATP synthase F1 sector subunit alpha 2, F-ATPase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TUSA_HAMD5
Sequence: MKDPLNHYDHFLDTLGLRCPEPLMMLRKTARDLTIGQTLLMISDDPSTLSDIPAFCRFMGHHLSAKKADRIPYQYLIVIGCLE
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YN59_YEAST
Sequence: MVIYYGKKNCTLLLLLFILCNIYSGSNILLISCSFFFLVSGTSIQLNIINANRQAANMYPSLKSILDTIIGVKSDIKKLNIQLINVQIAIDMALVLRGNNSDTSTNVTGPNVIANQKIKQQVTIIKTIFEKSVSLPNVPTVAYVII
What are the official names of this protein?
Putative uncharacterized protein YNL319W.
Protein: RS5_STRA1
Sequence: MAFKDNAVELEERVVAINRVTKVVKGGRRLRFAALVVVGDRNGRVGFGTGKAQEVPEAIRKAVEAAKKNMVEVPMVGTTIPHEVRSEFGGAKVLLKPAVEGAGVAAGGAVRAVIELAGVADITSKSLGSNTPINIVRATVEGLKQLKRAEEVAALRGISVSDLA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: FPG_BURCH
Sequence: MPELPEVEVTRRGIEPFVAGRRVERVDVRTAMLRWPVPAGLAEQLRAREVLAVERRGKYLLFEVDAGWFIVHLGMTGTLRVLPAAGVPVAAKHDHIDWIFDEFVLRFRDPRRFGAVLWHPREAGDVHAHPLLASLGVEPFSPAFTGALLHARTRGRTVSVKQALLAGDMVVGVGNIYASESLFRAGIRPTTAAGKVSLPRYERLADAVRATLADAIERGGSTLRDFVGSNGESGYFQLDCFVYDRAGQPCRVCGTPVRQIVQGQRSTYFCPTCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.