PharMolix/UniProtQA huggingface dataset:
Protein: SHQ1_DROME
Sequence: MLNGQIAHSYLENSCTLIIPRPPVLNQSSKSAQPAAAAAASSSAGEEFGQEAGSGLAEAEALHVDRIRNCDIFVDAHDLYFYADVKLYKFHSRRTFDLRELKTLLIKFNTTENHYQICLRCLPLTAGAQEGPGGERGGGGGTGDAAKQWNSRKEYIAAFLHLPTLSANLPDKQPLVQEWKLKRITDQCQLQLDDHERTYKLTNNFGYGYASEYSGPLDLSELDRATCRVSEPHRMSPIQRRQERVVDEMKRFSREQYKINFVELQVPSGHQNPLRYKPKIYETSMTQEQAHLLHNISRMQTREQQPCDVFRQNEIDCGLISILLAICYDVRTTNNEPTCESGWTRSILCPLYCYFEQFDNYRDVLVAFLRRMITYPLYRNFELGRQCVRDAIEVLKGGRNWLINQLLLTHQQFASSDPSRDSFNNYYLEDYIRYVTSPSACSDEHMRLLARNLKNVLMDVNKQHLGLGVTEIETELIKELMQEMRIDAGSQGSSPQQQHGDDDLDLDNDTSGQEDETTTDDESVITDSFYSVDMDMRLIENEIVYEDDEEDEDDDEDGDDDEDGDGDEDEDEDEDEDDSSSSTTTSSEAEGNSVIEQCSNSETAASTT
What is the function of this protein?
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs).
What are the official names of this protein?
Protein SHQ1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SHQ1 family.
Protein: Y21B_METJA
Sequence: MFNKVAFMNIPMMDLIMIVIAIIITIGSFLFIAYLIFKYSKIKKQVKIIREVKINLPKMLKSNMIKNSFLIISLLCFYFGMLYIAGELVISHILFIAICWIVVFLYIIIKGETRGYICEEGLLVSGVLYSWKEFKDVKIEDNYIILTTPIHKIVIKKEKGVENILKNYLKRN
What are the official names of this protein?
Uncharacterized protein MJ0210.1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYR1_ARATH
Sequence: MPSELTPEERSELKNSIAEFHTYQLDPGSCSSLHAQRIHAPPELVWSIVRRFDKPQTYKHFIKSCSVEQNFEMRVGCTRDVIVISGLPANTSTERLDILDDERRVTGFSIIGGEHRLTNYKSVTTVHRFEKENRIWTVVLESYVVDMPEGNSEDDTRMFADTVVKLNLQKLATVAEAMARNSGDGSGSQVT
What is the function of this protein?
Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition.  Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (PubMed:19407142, PubMed:19624469, PubMed:19769575, PubMed:23844015, PubMed:21658606).  Can be activated by both (-)-ABA and (+)-ABA (PubMed:23844015).  Promotes drought tolerance (PubMed:29970817).
What are the official names of this protein?
Abscisic acid receptor PYR1, ABI1-binding protein 6, Protein PYRABACTIN RESISTANCE 1, Regulatory components of ABA receptor 11.
What is the protein family that this protein belongs to?
Belongs to the PYR/PYL/RCAR abscisic acid intracellular receptor family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Nucleus. Cell membrane. Vacuole. Note=Localizes at the plasma membrane in the presence of a CAR protein (By similarity). Localized transiently in the vacuole when in complex with RSL1 (PubMed:27495812).
Protein: TGT_SHIFL
Sequence: MKFELDTTDGRARRGRLVFDRGVVETPCFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGNKNALFGIIQGSIYEDLRDISVKGLVDIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKYKSDTGPLDPECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RR4_FESPR
Sequence: MSRYRGPRLKKIRRLGALPGLTRKTPKSGSNLKNKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKRSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVNIPSFRCKPRDIITTKDNQRSKGLVQTLMASSDPGKLPKHLTIDTLEYKGLVNKILDRKWVGLKINELLVVEY
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CHSP1_RAT
Sequence: MSSEPPPPPQPPTHQTSIGLLDTPRARDRSPSPLRGNVVPSPLPTRRTRTFSATVRASQGPVYKGVCKCFCRSKGHGFITPADGGPDIFLHISDVEGEYVPVEGDEVTYKMCSIPPKNEKLQAVEVVITHLAPGTKHETWSGHVISS
What is the function of this protein?
Binds mRNA and regulates the stability of target mRNA.
What are the official names of this protein?
Calcium-regulated heat stable protein 1, Calcium-regulated heat-stable protein of 24 kDa, CRHSP-24.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded (By similarity).
Protein: YESS_BACSU
Sequence: MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFLSIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFTFSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDHSIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQNREVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSAAPLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTWQASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLRFRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQLSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPSLFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAKELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISELREPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADALGMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNRIFKKQVGMPPGVFRQMYQETP
What is the function of this protein?
Probable transcription factor regulating the pathway responsible for rhamnogalacturonan depolymerization.
What are the official names of this protein?
HTH-type transcriptional regulator YesS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PAXP_PENPX
Sequence: MDLSDFHISTPLRYFHEEASLLWKLGVFAVLVYFLLPKPTYKTNVKVPTVKYMGPWMPEILSRIFFNSHAPTVIYKGYEKFKTSAFKVVKPDGDLVVLSTRYAEELRQMPSTTLNALEATFTDHVGGYTTILTDSHLHTETIQKKLTPAIGRLIPRMISELDHAFEVEFPTCDDQFASINPYTVFLRLVARVGARIFIGDELCREEKWLQASIDYTKNIFLTIALMRPMPGFLHPIVGRILPSSRSLKDQLSYIQQDLLGPVIKERRRLEASSDSEYKKPDDFLQWMMDLAQNENESHPDNLSHRLLGITSMAVVHTSAMSMTHILYDLLTMPDLIEPLRDEIRNEIKDWNKATQADLSRLIIMDSFLKESQRLNPPGDLSFHRVVKKDLTLSDGLFLPKGTHICMAAGPISKDPDVVSDPDTFDAFRFVKQRTATSGFVSTGPNNMHFGLGRYACPGRFFAAFVIKLILSRFLMDYDFKFETEHKERPKNLLIGDKIVPNVATPILIKRRATKA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the ATM2 gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels (PubMed:11169115, PubMed:23949005).  PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis (PubMed:23949005).  Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline (PubMed:23949005).  Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ (PubMed:23949005, PubMed:17428785).  Finally paxilline can be mono- and di-prenylated by paxD (PubMed:23949005).  PaxP can also utilized beta-paxitriol and alpha-PC-M6 as substrates converting them to paxilline (PubMed:17428785).
What are the official names of this protein?
Cytochrome P450 monooxygenase paxP, Paxilline synthesis protein P.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NDUBB_MOUSE
Sequence: MAARLLSLYGRCLSAAGAMRGLPAARVRWESSRAVIAPSGVEKKRQREPTMQWQEDPEPEDENVYAKNPDFHGYDSDPVVDVWNMRAVFFFGFSIVLVFGTTFVAYVPDYRMQEWARREAERLVKYREVNGLPIMESNYFDPSKIQLPEDD
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial, Complex I-ESSS, CI-ESSS, NADH-ubiquinone oxidoreductase ESSS subunit, Neuronal protein 15.6, Np15.6, p15.6.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFB11 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Note=The interaction with BCAP31 mediates mitochondria localization.
Protein: NTM1A_BOVIN
Sequence: MTSEVIEDEKQFYSKAKTYWKEVPATVDGMLGGYGHISSIDINSSRKFLQRFLREGQNKTGTSYALDCGAGIGRITKRLLLPLFGVVDMVDVTEDFLVKAKTYLGEEGKRVRNFFCCGLQDFSPEPQSYDVIWIQWVIGHLTDQHLAEFLRRCKRGLRPNGIIVIKDNMAQEGVILDDVDSSVCRALDVVHRIVRSAGLSLLAQERQENLPDEIYHVYSLALR
What is the function of this protein?
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved.  Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif.  Some of the substrates may be primed by NTMT2-mediated monomethylation.  Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1).  Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET.  Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
What are the official names of this protein?
N-terminal Xaa-Pro-Lys N-methyltransferase 1, Alpha N-terminal protein methyltransferase 1A, Methyltransferase-like protein 11A, X-Pro-Lys N-terminal protein methyltransferase 1A, NTM1A.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. NTM1 family.
What are the subcellular locations of this protein?
Nucleus. Note=Predominantly nuclear.
Protein: LY6D_HUMAN
Sequence: MRTALLLLAALAVATGPALTLRCHVCTSSSNCKHSVVCPASSRFCKTTNTVEPLRGNLVKKDCAESCTPSYTLQGQVSSGTSSTQCCQEDLCNEKLHNAAPTRTALAHSALSLGLALSLLAVILAPSL
What is the function of this protein?
May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development.  Marks the earliest stage of B-cell specification.
What are the official names of this protein?
Lymphocyte antigen 6D, Ly-6D, E48 antigen.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: COX3_RHISA
Sequence: MMFHPFHLVEKSPWPITSSISALSLTLGFVSYFQNLSMYLILLAVLMITISSFQWWRDISREGSFQGFHTHWVLNGLKMGMILFILSEVFFFVSFFWAFFHSSLSPNIEIGSQWPPKGIYPFNPFEIPLLNSTILISSGITVTWSHHAIMNKNYISALNSLLITILLGVAFTMFQGFEYFQAQFKISDGIFGSTFFMTTGFHGLHVLIGSIFLLVSYFRIKNQLISSDHFFGFEASAWYWHFVDVVWLFLFTFMYWW
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NUOI_MYCSK
Sequence: MPKLWDAVAGFAVTFGTLFKKPITEEYPEKPGPVAPRYHGRHQLNRYPDGLEKCIGCELCAWACPADAIYVEGDDNTADERYSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTNDYEMADDNRADLIWGKDKLLAPLQDGMLAPPHPMAPGATDDDYYLGRIGPATEDVR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NUOI_RICAE
Sequence: MIHYLKSFFLYEIVRGMALTLKYFFKPKVTINYPYEKSPISPRFKGEHALRRYENGEERCIACKLCEAICPAQAIVIEADEREDGSRRTTRYDIDMTKCIYCGLCQEACPVDAIVEGPNFEFASLTHTALIYDKERLLQNGDRWEQALASKLRKDYEYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS3_HALMA
Sequence: MADEQQFIEDGLQRTQIDEFFAEELGRAGYGGMDVAKTPMGTQIVLKAEKPGMVIGKGGKNIRKITTELEDRFNLDDPQVDVQEVDEPDLNARIVADRLANALERGWYFRKAGHTTIDRIMESGALGAEIVLSGKVTGARSRVEKFNRGYVKHNGEPAEEIVDSGVGVAVMKLGTIGVRVKIIPPNAELPDDFEIYEDVDVEDYVADTDGESVEELLEGEPEDSETAEELDEDVAAGADDDSEADEEFVDEEIVEEDVEVPTDDDVEDVDVDELEEAVDEELDEDVEAEAEELMDEMDEEGDDE
What is the function of this protein?
Binds the lower part of the 30S subunit head.
What are the official names of this protein?
30S ribosomal protein S3, HS1, HmaS3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: VPB32_MYCTO
Sequence: MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Antitoxin VapB32.
Protein: PKHF2_MOUSE
Sequence: MVDRLANSEANTRRISIVESCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGELRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSTGDMAACQPTRSDSYSQSLKSPLNDASDDDDDDDSSD
What is the function of this protein?
May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport (By similarity).  Enhances cellular sensitivity to TNF-induced apoptosis.
What are the official names of this protein?
Pleckstrin homology domain-containing family F member 2, PH domain-containing family F member 2.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots. May translocate to the endoplasmic reticulum in the early phase of apoptosis.
Protein: MUTL_BACCQ
Sequence: MGKIRKLDDQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAEEDCIVAFERHATSKIKDENDLFRIRTLGFRGEALPSIASVSELELITSTGDAPGTHLIIKGGDIIKQEKTASRKGTDITVQNLFFNTPARLKYMKTIHTELGNITDIVYRIAMSHPEVSLKLFHNEKKLLHTSGNGDVRQVLASIYSIQVAKKLVPIEAESLDFTIKGYVTLPEVTRASRNYMSTIVNGRYVRNFVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEVRFSKEQELLKLIEETLQAAFKKIQLIPDAGVTTKKKEKDESVQEQFKFEHAKPKEPSMPEIVLPTGMDEKQEEPQAVKQPAQLWQPPKQEWQPPQSLVREEQSWQPSTKSIIEEPIREEKSWNSNDEDFELEELEEEVQEIEEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGLYMIDQHAAQERINYEYFRDKVGRVAQEVQELLVPYRIDLSLTEFLRVEEQLEELKKVGLFLEQFGHQSFIVRSHPTWFPKGQETEIIDEMMEQVVKLKKVDIKKLREEAAIMMSCKASIKANQYLTNDQIFALLEELRTTTNPYTCPHGRPILVHHSTYELEKMFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: SSRP_STRE4
Sequence: MAKGEGNVLAQHKKARHDYHIVETVEAGIVLTGTEIKSVRAARIQLKDGFAQIKNGEAWLVNVHIAPFEQGNIWNADPERTRKLLLKKREIQHLADELKGTGMTLIPLKVYLKDGFAKVLIGLAKGKHDYDKRESIKRREQDRDIRRVMKSVNRR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: COX2_PONAB
Sequence: MAHAAQVGLQDATSPIMEELVIFHDHALMIIFLICFLVLYALFLTLTTKLTNTSISDAQEMETIWTILPAIILILIALPSLRILYLTDEINDPSFTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPVEAPVRMMITSQDVLHSWTVPSLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PEPE_ECO27
Sequence: MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLAPLGVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEAGHRF
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFUA_STUS1
Sequence: MSAITITEAAHDYLADLLAKQNTTGIGIRIFITQPGTPYAETCIAYCKPGEEKPDDIALALKSFTAWIDGTSEPFLEDALVDYATDRMGGQLTIKAPNAKVPMVNEDSPMNERINYYLQTEINPGLASHGGQVTLIDVVEEGIAVLQFGGGCQGCGQADVTLKEGIEKTLLARIPELKGVRDVTDHTNRENAYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: STP_MYCTU
Sequence: MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVASYSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTTARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPTLGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQLLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNPMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGLMILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRSSALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRAIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVFLAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMPGATWCRLWPA
What is the function of this protein?
Contributes to spectinomycin and tetracycline resistance.
What are the official names of this protein?
Multidrug resistance protein Stp, Spectinomycin tetracycline efflux pump.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EmrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YZ27_AQUAE
Sequence: MIKEFEKNEKVKNVVLNYYYTKVINSPIFNEAQKSLVRKKAVEESAEMFQKLAEKKKEILISPQKIQEILKNKREDKDEKVNVAVCDGEIFYNGKSVVEISIPEESVKKTVIAIKDYIELSTETSEEHRFLTGEAIIFSFYSVFLKEVREKATELMKDINKFPVFSLLIGTPKAGKTTLLNFIAKLLGTEKIYYGKLKETRNSKANTFEAILYIDNRMPVLIDEVPPEHLRDKRALGSKLKAKGIEWRLGSKKRSYVNQ
What are the official names of this protein?
Uncharacterized protein aq_aa27.