PharMolix/UniProtQA huggingface dataset:
Protein: VPU_HV1W2
Sequence: ERAEDSGNESEGDHEELSALVDMGHDALWDVDDL
What is the function of this protein?
Enhances virion budding, by targeting human CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its receptor human CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to interfere with the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo (By similarity).
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: TKT_CERSP
Sequence: MKDIGAAQETRMANAIRALAMDAVEKAKSGHPGMPMGMADVATVLFNRFLTVDPSAPKWPDRDRFVLSAGHGSMLLYAIHHLLGYADMDMDQIRSFRQLGARTAGHPEYGHAEGIEVTTGPLGQGIATAVGMALAERMKNARYGDDLVDHFTYVIAGDGCLMEGISHEAIDMGGHLGLGRLIVLWDDNRITIDGDSGISTSTDQKAPFAASGWHVLACDGHAPEEIAAAIEAARRDPRPSMIACRTVIGYGAPNKQGGHDVHGAPLGAAEIAAARERLGWDHPPFEIPADLYEAWGRIAARGADARAAWETRLQASPLRAAFETAEAADTSALPPAIAAYKARLSAEAPKVATRKASEMALGVVNEALPFAVGGSADLTGSNLTRSKGMVSVAPGAFAGSYIHYGIREHGMAAAMNGIALHGGLRPYGGTFMAFADYCRPSIRLSALMGVPVTYVMTHDSIGLGEDGPTHQPVEHLASLRAIPNLAVIRPADAVETAEAWEIAMTATSTPTLLVLSRQNLPTVRTEHRDENLTARGAYLLRDPGERQVTLIATGSELELALAAADLLAAEGIAAAVVSAPCFELFAAQPADYRATVLGRAPRVGCEAALRQGWDLFLGPQDGFVGMTGFGASAPAPALYQHFNITAEAIVKSAKERI
What is the function of this protein?
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
What are the official names of this protein?
Transketolase, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: IF4E2_CAEEL
Sequence: MSEEPVAAPGTISHPVYKLKRNWTWWYLNDERNKSWEERLKNVKTFSSVGEFWALHDSIKPPSGLNPPSDYNVFRDGIEPMWEVPQNQNGGRWLITIEKGRTPEIMDTIWTEILMAMIGEQFSDDIESLCGIVCNVRGKGSKISVWTTNSADDGANLRIGGVLKQVLNNASMIHQRPLYDVLRYEDHESCQKKTSSGVKAKHAIYAVEPREEKAPVPVSTETPATPAT
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.  All 5 eIF4E proteins bind monomethyl cap structures.  Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing.  Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps (PubMed:10744754, PubMed:9553113).  Probably by regulating mRNA translation in somatic cells, negatively regulates lifespan independently of daf-2/insulin and let-363/TOR pathways (PubMed:17277769).  Negatively regulates resistance to oxidative stress (PubMed:17277769).  May play a role in embryonic development (PubMed:17277769).
What are the official names of this protein?
Eukaryotic translation initiation factor 4E-2, eIF-4E-2, eIF4E-2, eIF-4F 25 kDa subunit, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
Protein: SL9B1_MOUSE
Sequence: MSEHDVESNKKDDGFQSSVTVEMSKDPDSFHEETVEPKPELKEPEPKEPEPKEPERKEPERKEPERKEPERKEPERKVPGRRETQTKETQTTEIERKETKKKRGTNSYCPPQGTINKTITDGAALIALWTLLWALIGQEVLPGGNLFGLVVIFYSAFLGGKILEFIKIPVVPPLPPLIGMLLAGFTIRNVPIIYEFVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACSAALFSHFIMNFPWQWGFLLGFVLGAVSPAVVVPNMLMLQENGYGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSGSVISNILSSLRDVLIGVLVGIVMGVFVQYFPSGDQERLTQRRAFLVLSMCISAVLGCQHIGLHGSGGLVTLVLSFMAAKRWAEEKVGIQKIVANTWNVFQPLLFGLVGTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSFANFRFKEKVFIALSWIPKATVQAVLGPLALETARVMAPHLEGYAKAVMTVAFLAILITAPNGALLIGILGPKILEQSEVTFPLKVELSNFHH
What is the function of this protein?
Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa (PubMed:20036903).  Involved in sperm motility and fertility (PubMed:20036903, PubMed:27010853, PubMed:19409551).
What are the official names of this protein?
Sodium/hydrogen exchanger 9B1, Na(+)/H(+) exchanger-like domain-containing protein 1, NHE domain-containing protein 1, Sodium/hydrogen exchanger-like domain-containing protein 1, Solute carrier family 9 subfamily B member 1, Testis specific sodium-hydrogen exchanger, MtsNHE.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Protein: SEC11_LACBS
Sequence: MFTEEIKAFRRLGFRHVLLQALNFATVIASGLMIWKGLGIITNSESPIVVVLSGSMEPAFYRGDLLFLTNPVSEQYKTGDITVYKIPGADIPIVHRVLETHDVPPKGRKAKEAGEPASQLMLTKGDNNYVDDLELYQGLQWLERKHIVGKVRGFLPYVGYVTIAMNDFPQLKYALLGVLGLLALLQRE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: SAE2_DANRE
Sequence: MAELVGPLRKQLADSLSSCRVLVVGAGGIGCELLKNLVLTGFKNIEVIDLDTIDVSNLNRQFLFQKKHVGKSKAQVAKESVLRFCPSANITAYHDSIMNPDYNVEFFRNFQLVMNALDNRAARNHVNRMCLAADIPLIESGTAGYLGQVTVIKKGQTECYECQPKPTQKTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDTADPEAAWNPADAAARATASDQDGDIKRVSTKEWARSTGYDPIKLFNKVSALSQTSPYLFKDDIMYLLTMDKLWKKRKAPLPLEWEEINQLGSQEQVIGSGLKDQQVLGVQGYAQLFQHSVETLRSQLKEKGDGAELVWDKDDPPAMDFVTAASNLRMNVFSMNMKSRFDVKSMAGNIIPAIATTNAVIAGLIVLEALKILNSDFEQCRTIFLNKQPNPRKKLLVPCALDPPNASCYVCASKPEVTVKLNVHKTMVQALQDKILKEKFGMVAPDVQIEDGKGTILISSEEGETEANNNKFLSDFGIRNGSRLQADDFLQDYTLLVNVIHSEELEKDVEFEVVGDAPDKAPAPSAPEEGKNIANGNKDSAQPSTSSKAAVEDDDVLLVDSDEEPSSSTMDTESSNRKRKHHDAETDDASSKRKRLDQQPADDDDEDIIALD
What is the function of this protein?
The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3.  It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).
What are the official names of this protein?
SUMO-activating enzyme subunit 2, Ubiquitin-like 1-activating enzyme E1B, Ubiquitin-like modifier-activating enzyme 2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
Protein: PLNKY_LACPN
Sequence: GRADYNFGYGLGRGTRKFFNGIGRWVRKTF
What is the function of this protein?
Bacteriocin with activity against species of Lactobacillus, Lactococcus, Pediococcus, Leuconostoc and against B. subtilis and, to a lesser extent, against B. coagulans, B. cereus and species of Enterococcus, Listeria, Kocuria, Staphylococcus, Corynebacterium, Salmonella, Pseudomonas and Escherichia.
What are the official names of this protein?
Bacteriocin plantaricin KL-1Y.
What are the subcellular locations of this protein?
Secreted.
Protein: RL9_BRUME
Sequence: MEVILLERIGRLGQMGDTVKVKDGYARNFLLPQGKALRANEANKKKFEGQRAQLEAQNLERKNEAQAVADKLNGESFIVVRSAGETGQLYGSVSTRDIAEIITANGFTLHRNQVELNHPIKTIGLHEVSVSLHPEVQVKVMVNIARSTEEAECQAKGEDLTSIEAIYGIEEQPLSEEVFDDEDEAEDQA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: IMDH_METJA
Sequence: MFLKKLIEAKKAYTFDDVLLVPNASWVEPKDTDVSTDLAGLKLNIPIVSAAMDTVTEKEMAIALARLGGLGVIHRNMSIEEQVHQVQAVKKADEVVIKDVITVSPDDTVGEAINVMETYSISGLPVVDNEDKLVGIITHRDVKAIEDKTKKVKDVMTKDVVCAKEDVEEEEALELMYANRVERLPIVDDENRLIGIITLRDILKRRKYPQAARDKKGRLLVAAACGPHDFERAKALIEAEVDAIAIDCAHAHNMRVVENVKKFKEMLEGTDIKLIVGNIATKEAAEDLIKAGADVLKVGIGPGSICTTRVVAGVGVPQLTAVAEVADVAKEHNVPIIADGGIRYSGDIAKAIAAGADAVMLGSLLAGTDEAPGQLMVINGRKYKQYRGMGSLGAMTGGVGAGADRYFQAPAKSHMKHVKLVPEGVEGAVPYKGPVSEVVFQLIGGLRASMGYCGAKNLKEMQEKARFVIITPSGQVESHPHDIIITNEAPNYPLGK
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: RS2_SYNS3
Sequence: MAVVTLAEMMEAGAHFGHQTRRWNPKMSRYIYCARNGVHIIDLVQTAVCMNNAYKWVRSAARSGKRFLFVGTKKQASEVVAQEALRCGSSYVNQRWLGGMLTNWTTMKARIDRLKDLERMESSGAIAMRPKKEGAVLRRELERLQKYLGGLKNMRRIPDVVVLVDQRRETNAVLEARKLDISLVSMLDTNCDPDLCEVPIPCNDDAVRSIQLVLSRLADAINEGRHGGQDGRGDDGQG
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PDXS_METM6
Sequence: MKKLGTDLLKRGFAKMVKHGVVMDVTNVEQAQIAEDAGAAAVMALERVPADIRVQGGVARMSDPEMILEIKDAVSIPVMAKARIGHFVEAQLLESIGVDMVDESEVLTPADEVNHIDKRAFTAPFVCGARNLGEALRRIDEGAAMIRTKGEAGTGNVVEAVKHMRAVNEGIARVVGYKEMGLEAELIQMARNELKVPMELISEVAELKRLPVVNFAAGGIATPADAALMMQMGCDGVFVGSGIFKSGNPATRAKAIVEATYNFDKPAVIGEVSKNLGEAMVGINIDEIPEEKLLAKRGI
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: RR3_HORVU
Sequence: MGQKINPLGFRLGTTQKHHSFWFAQPKNYSEGLQEDKKIRDCIKNYIQKNRKKGSNRKIESDSSSEVITHNRKMDSGSSSEVITHIEIQKEIDTIHVIIHIGFPNLLKKKGAIEELEKDLQKEINSVNQRFNISIEKVKEPYRQPNILAEYIAFQLKNRVSFRKAMKKAIELTKKADIRGVKVKIAGRLGGKEIARAESIKRGRLPLQTIRAKIDYCCYPIRTIYGVLGVKIWIFVDEE
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YDAG_ECOLI
Sequence: MVHYEVVQYLMDCCGITYNQAVQALRSNDWDLWQAEVAIRSNKM
What are the official names of this protein?
Uncharacterized protein YdaG.
Protein: VATD_METB6
Sequence: MALRDIKPTRSELINLKRKIQLSQRGYKILKMKRDGLIMEFFKILSEAKDSRGELLRRYKHAVEMMAVANTVEGALGVKAAAFSVKETPEITLKSKNIMGVVVPEIESSKVKKTLADRGYGVLGTSPVIDETASSFEDLVEAIIESAEIETTMKRLLDEIEKTKRRVNALEFKVIPELTEARDFIKMRLDEMEREELFRMKKIKARGSS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: PANC_BORPE
Sequence: MKVVHTIQDLRDHLRGQNRVAFVPTMGNLHEGHLALMKLARQHGDPVVTSIFVNRLQFGPNEDFDRYPRTLPDDVAKMERDRDVYLVFAPDEREMYPEPQNYRVLPPDDLGDILEGEFRPGFFTGVCTVVMKLLACVQPRVAVFGKKDYQQLMVVRNMCRQLQLPVEILAHETVRADDGLALSSRNRYLSEAERAEAPVLYETLRGIAQRRAGGEQDPAALERVAAQALADRGWKVDYVAVRRQRDLKAPDVAEMSAGEPLVALAAAKLGATRLIDNLEF
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YD433_YEAST
Sequence: MTILHQSEDQIEVASEVAAASEAASEVASEAVSPEAASVAPEVDLVVQEVVTVAIPEVATVATPEADMVAPEVVTIVLEVVTIVQEVVIPEVAMVVQEMITVLQEVATVVQEVVMMVQEAIMVLQEMHTEPEMLHVKDHQPGKPFI
What are the official names of this protein?
Putative uncharacterized protein YDR433W.
Protein: RL22_MYCSS
Sequence: MTTATTNPSTYPNAMAVARYVGISASKARRVIDLVRGKSVEEALDILRWAPQQASEPVAKVIASAAANAQNNEGLDPSTLVVATIHADEGPTAKRIRPRAQGRAFRIRKRTSHITVIVESRPSREGRRGGAGESAGGARARRAQGSKAAAAKKAPASSSKKAATTTEASEEAKGGSQ
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: MINE_FRATT
Sequence: MLAKLFGLSKKQQSASVAKERLQIIVAHQRSELHPRSSKISSHLLAELKDEIIEVVKKYVALSEENIRDIDLKVEDSSKNSTIEVNIPFN
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: OAT2_STAAC
Sequence: MTKSEKIIELTNHYGAHNYLPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKDQADKVTLVSRAFHSDNLGEWYEKICKLAGKDKALPMNTGAEAVETALKAARRWAYDVKGIEPNKAEIIAFNGNFHGRTMAPVSLSSEAEYQRGYGPLLDGFRKVDFGDVDALKAAINENTAAVLVEPIQGEAGINIPPEGYLKAIRELCDEHNVLFIADEIQAGLGRSGKLFATDWDNVKPDVYILGKALGGGVFPISVVLADKEVLDVFTPGSHGSTFGGNPLACAASIAALDVIVDEDLPGRSLELGDYFKEQLKQIDHPSIKEVRGRGLFIGVELNESARPYCEALKEEGLLCKETHDTVIRFAPPLIITKEELDLALEKIRHVFQ
What is the function of this protein?
Catalyzes the interconversion of ornithine to glutamate semialdehyde.
What are the official names of this protein?
Ornithine aminotransferase 2, OAT 2, Ornithine--oxo-acid aminotransferase 2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPRE1_MYCTO
Sequence: MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKLGRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
What is the function of this protein?
DprE1 is a highly vulnerable and fully validated tuberculosis drug target.
What are the official names of this protein?
Decaprenylphosphoryl-beta-D-ribose oxidase, Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase, Decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase subunit DprE1, Decaprenyl-phosphoribose 2'-epimerase subunit 1, Decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase, Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit, FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase.
What is the protein family that this protein belongs to?
Belongs to the DprE1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: OTC_BIFLS
Sequence: MTPELRHMLRDDDLNHEEQKQVLELAIKFHHDRFYKQPFAGPQAVAVLFDKPSTRTRSSFSIGVAELGGYPLVIDKSGSQLGRGEPVADTARVLDRMAYGVVWRTFGQDRVEEMAKYSTHPVVNALTDDFHPCQILADFQTIAEHRGGVDNLKNQTIAYLGDAANNMANSYLLGGAVAGMDVRVAGPHGYLPRPDIVADAKRVAAETGGSILVTTDAKEAVKDADCVFTDTWVSMGEEAEYAIRSKPFWDYQVNTELMALAKPDALFQHCLPAYRGKEVTAEVIDGPQSVVWDEAENRLHAQKALLTWLTGKARGDESLLA
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1433C_TOBAC
Sequence: MAVAPTAREENVYMAKLAEQAERYEEMVEFMEKVSNSLGSEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEEHVNSIREYRSKIENELSKICDGILKLLDAKLIPSAASGDSKVFYLKMKGDYHRYLAEFKTGAERKEAAESTLTAYKAAQDIATTELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQDDGADEIKEDPKPDEAKN
What are the official names of this protein?
14-3-3-like protein C, 14-3-3-like protein B.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: DPOD2_MOUSE
Sequence: MFSEQAAQRAHTLLAPPSASNATFARVPVATYTNSSQPFRLGERSFNRQYAHIYATRLIQMRPFLVSRAQQHWGSRVEVKKLCELQPGEQCCVVGTLFKAMSLQPSILREISEEHNLVPQPPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVLAVLGSAKDDGRFQVEDHCFADLAPQKPVPPLDTDRFVLLVSGLGLGGGGGESLLGTQLLVDVVTGQLGDEGEQCSAAHVSRVILAGNLLSHNTQSRDSINKAKYLTKKTQAASVEAVKMLDEILLQLSASVPVDVMPGEFDPTNYTLPQQPLHPCMFPLATAYSTLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMEDHLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFPECPHVYFCGNTPSFGSKIIRGPEDQVVLLVAVPDFSSTQTACLVNLRSLACQPISFAGFGAEQEDLEGLGLGP
What is the function of this protein?
Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex.  As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair.  Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4.  They exhibit differences in catalytic activity.  Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4.  Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides.  Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated.  Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation.  Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR).  Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH).  Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion.  Also involved in TLS as a component of the DNA polymerase zeta complex.  Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7.
What are the official names of this protein?
DNA polymerase delta subunit 2, DNA polymerase delta subunit p50.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase delta/II small subunit family.
What are the subcellular locations of this protein?
Nucleus. Note=Recruited to DNA damage sites within 2 hours following UV irradiation.
Protein: PEPX_STRP4
Sequence: MRFNQYSYINFPKENVLSELKKCGFDLQNTANHKDSLETFLRRFFFTYQDTNYPLSILAADKKTDLLTFFQSEDELTADIFYTVAFQLLGFSYLVDFEDSDVFRKETGFPIIYGDLIENLYQLLNTRTKKGNTLIDQLVSDGLIPEDNDYHYFNGKSLATFSNQDVIREVVYVESRVDTDQKGLSDLVKVSIIRPRFDGKIPAIMTASPYHQGTNDKASDKALYKMEGELEVKLPHKIELEKPQLNLVQPQGKAELIAEAEEKLTHINSSYTLNDYFLPRGFANLYVSGVGTKDSTGFMTNGDYQQIEAYKNVIDWLNGRCRAFTDHTRQRQVKADWSNGKVATTGLSYLGTMSNGLATTGVDGLEVIIAEAGISSWYNYYRENGLVTSPGGYPGEDFDSLAELTYSRNLLAGDYIRGNEAHQADLEKVKAQLDRKTGDYNQFWHDRNYLLNAHKVKAEVVFTHGSQDWNVKPLHVYQMFHALPTHIHKHLFFHNGAHVYMNNWQSIDFRESINALLTKKLLGQETDFQLPTVIWQDNTAPQTWLSLDNFGGQENCETFSLGQEEQAIQNQYPDKDFERYGKTYQTFNTELYQGKANQITINLPVTKDLHLNGRAQLNLRIKSSTNKGLLSAQLLEFGQKKYLQPYPAILSARTIDNGRYHMLENLCELPFRPEAQRVVTKGYLNLQNRNDLLLVEDITADEWMDVQFELQPTIYKLKEGDTLRLVLYTTDFEITIRDNTDYHLTVDLAQSMLTLPC
What is the function of this protein?
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Xaa-Pro dipeptidyl-peptidase, X-Pro dipeptidyl-peptidase, X-prolyl-dipeptidyl aminopeptidase, X-PDAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUTA2_BACAA
Sequence: MKVSLFITCLSDVFFPQVGKSVVEIMNQCGVELDFPEGQTCCGQPAYNSGYQEDAKLAAKQMIKAFEHSEYIVTPSGSCASMVHHYYKEMFKGDSEWYEKAVHLADRTYELTDFVVNILGKNDWKSKLVEKAVFHQSCHMSRALGIKEEPLKLLSQVEGLDIKELPYCQDCCGFGGTFAVKMSSISETMVDEKIKHIEATEANLLIGADMGCLMNIGGRLRRENKNIQVLHVAEVLAKGLNK
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
What are the official names of this protein?
Lactate utilization protein A 2.
What is the protein family that this protein belongs to?
Belongs to the LutA/YkgE family.
Protein: GLGB_VIBPA
Sequence: MSSQRWLWRNQHSVQTNIGSREKDLKITKTKKIKKKHERAYELLAEAAYSDPFAALGPFIDDGEGSLRVWMPGANKVELLVNGEPRVALERDGDSGFILKEQRDLHLTHYRLAVDWNGVEQIIDDPYQYHNIYQEYEHLHTPKDMYHYMGAHFVTLERGGENISGVRFLVYAPHASAVSLVGCFNQWDGRRHPMQRLDYGIWGLFIPGLEEGVQYKFELKGPNGEGLPHKQDPWGFYSEQYPSFASITYDHKRYQWQDAKWQNRAVTQKRDEALSFYELHAGSWKRDGKGDFLNYRELAEQLVPYLVDMGYTHVELMPVSEHPFYGSWGYQPVGLFAPTSRYGSPDDFKFFVDACHQAGIGVVLDWVPAHFPSDDHGLANFDGTPLFHDPDPRRGWHQDWNSYIYDLGREHVRRFLVSNALYWFEQFHIDGIRVDAVASMLYLDYSRSHDQWVPNVDGGNENYDAIATLKWMNEEVYKHFPNAMTIAEESTAFPGVSAPTFMGGLGFGFKWNMGWMHDSLSYVKEDPVHRKYHHNTITFPLVYAHSENYVLSLSHDEVVYGKGSIHNKMPGDEWQQTANLRAYYGYMYGQPGKKLNFMGAEIGQTAEWNHDDQLQWFLLEYERHQGVQKLMRDLNHLYRNEAAMHDQDCVPAGFEWRLQDEADASILAHERISKEGERILIITNFTPVPHERFRLGVPNVGQYELLLNTDDSKYGGSDFKVLTSVKTEKVESESLPQSLELRLPPLSTVFYKLHK
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.