Protein: PPSB_ASPOR
Sequence: MKVDERVAIIGTGCRFPGGSNSPHELWELLVNPRDVARKVPPDRFNIAAFHHPQMGHHGTTAAWESYFLDENIQRFDASFFNISPTEAAAMDPQQRLLLETVYESLDRAGLRLEELQGTQTGVFCGLMRHDYHRLLTADMETNPPYALAGTAGSVLANRVSYFFDWHGPSITIDTACSSSLVAVHLACESLRKGECSLAIVGGSNLLLSPDPYIWESKMQLLSPTNRCHMWDASADGFACGEGVASVVLKRLTDALADGDHIECVIRATGVNSDGRSPGLTMPNSNAQSALIMDTYARAGLHPKQNPHDRCQFFEAHGTGTKAGDPQEAAAIQDALFGCNMEENQPNNETVYVGSIKTIIGHTAGAAGLAGVIRASLALQNGVVPPNLHFNRVSDTVAPHTTHLEVPTRAVRWPELPSGVPRRVSVNSFGFGGTNAHAILESFDQASRHPSTQVERVHQSQQALLPIVFSAASQSSLADLLEGYVQWLFDNPNVDLLGLASSLLLRRSTLRYRKAFIAASPDELRIKIQHELKRNTTDAQWAIMSPPKREGGNCILGVFTGQGAQWPQMGLELIQNCPQARMRLRELQQSLDDLPIEYRPGFTLLDELSAPESQSRLGETALSLPLRTALQIIQIDLLRALGITFNAVVGHSSGEIAAVYAAGILNATDAIRVAYLRGFAVKHAASRGKMIAVNLTEHQANAICSQPMWKGQVAVAAYNSPSNVTLSGDPETMDELVWLLRSLERHTHPLNTDAAYHSHHMQPCAGPYLQALKSCNVGVSSPSSVQMFSSVYKGLVVNSTDCALDSTYWCDNMLRPVLFSQAISTCLDQIPDINLIIEVGPHTALQGSIKHILHDTLSEGSVVPYIGLAHRGEDSIQSMAAAIGRLWAYLGMRDLKLQQYIQLFGPFRESCCVQSLPTYPFDHRTSYWAEPRLSQARLHCPIPPHPLLGVLSSECGRDEWRWRNYLHLEEIPWLTGHRILSDISYPPMGYIAMAVEAAQAASRSKPLQLVEIHSLIIERTISIPVEGPGIETLFKMDIESADNDTMTGTFQCQISCGNEFQKCASGRVILALGEANPTVLPSKSKGMSISYPMNVDKFYNQLQIVGGNVSDIFRGITELTRQEGGMQGVANVPSHDQPTFHPVVMTTALQVLWGAMMSDEGRLSALPLPVRIDSVTINPSCSHSGHVCLEASITRTGSGRNGCGDVLVFNGQGDGIAQLEGIHLTLSKPKNSSDDQALAFGTTVWGPLNPDPSIGYPKNLPYNLSIQNLQARLAVLYLRDAQAGLTAQDRERLVSHRRHYVAWMDSTLSKIRDGVHPHYPRDWLLGTIGELDSQTTSHETLIHVTHIVGQNLLQFLSGGEETILLKLRDNNIDLLTRYYQDDEAMRIMSDSLGKVVSQIVFRNPQLHVLEVGAGTGSATRAILSSIGRNYHSYTYTDISPAFFEGASAAFHTHEDRFIYKVLDVECDVTDQGFSMHSYDVVIASNVLHATRSLRRTLMNIRKLIKPSGYLVLLEGTDPDRVPTPFIFGAFEGWWLGEDDGRSGGPLIRREEWDVLLQCTGFGRCTSYTPTNQANLYGMSVIVSQPTDMPAIPVIEMDLLLVGGSTETTRQIILDLKTILRDSFVQISSCLSVDDFTPGPGISQLAILCLAELDHHSEETRWQWQDMRLMMTAASCLLWVSPADDPHSGVSKGLLRSLALDSSSGLLQHLTVIDSTPIGAEMLATTLMNLVRTKQEGMGRPEIELGWGEGILNIPRIVRDPTITQRLLASRSPCVFNLVDVREQAVCRLVSTEGSQKEKVDVYLTDPKNATTSAAKLFSNESIVQYQVHYCTQAALTITEKCSLFLIVGQNVFNGARQLALSISHGSIISTPLSWAWDVPASVSTDNEPKLLAAVAATILAFAIADLAGPSSTLWVHEAQAMGPTFMDALVSAVSDRQDIKNLTLTTSQCGLSDTRVHFVHPHSSTKTLSSVLPRNVSSAVLFDDGRLSRRSRLVLPRCANFRSFSDFFRPSSIIEEIDIQSVATILNSACAFVTRKGYEKGSSPRIISPREQSSVDSLEVVNWRQPTWIEAQILPASSLVSLSPTMAYVVVNMNHKLRRLVLDFLVRQGARHIVWVGEWSDEDFAWIAQLSRDEVHVAVVQMWAFLSSISDLYDQLTSTRKAEIPISSLQTYMPIGGIIYDGLKDSPQQAAENTLLLDELCGNDATFFILVGSLLGHIGFTDSNSFIGSTTGVLSGVISRRRQRGYVGSVLYLGEQNAVEDITLSAGDIREAFSEAILLGPPESTSNGEILAGLRNSEKWELVPKLSAWNESKTLLESDDKSQSAGQGQAHDTDAVTQLKLATSVAEAREIILQLFKEKLRRKLGLSSDVPLRRETLLHELGIDSLVAVDIHIWFARELGAKIPVVQIMGAGSIGSMVDEVVKRRNGFT
What is the function of this protein?
Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of 2,4'-dihydroxy-3'-methoxypropiophenone (PubMed:32885554).  The first step of the pathway is the conversion of acetate into acetyl-CoA by the acyl-CoA ligase ppsA (PubMed:32885554).  Acetyl-CoA is then used as a starter unit by the polyketide synthase ppsB and condensed with 4 malonyl-CoA unit to produce the pentaketide backbone (PubMed:32885554).  During polyketide extension, the polykedite chain is probably reduced and dehydrated by the KR and PT domains, respectively (Probable).  O-methylation seems to be catalyzed by an unknown methyltransferase rather than by the CMeT domain of ppsB (Probable).  Two hydroxylations and one further decarboxylation step catalyzed by yet unknown enzymes are then required to yield 4'-hydroxy-3'-methoxypropiophenone (Probable).  PpsC functions as a carrier protein to transport 4'-hydroxy-3'-methoxypropiophenone to a specific cell compartment in which 4'-hydroxy-3'-methoxypropiophenone is hydroxylated to 2,4'-dihydroxy-3'-methoxypropiophenone by a still to be identified enzyme (PubMed:32885554).
What are the official names of this protein?
Reducing polyketide synthase ppsB, 2,4'-dihydroxy-3'-methoxypropiophenone biosynthesis cluster protein B.