PharMolix/UniProtQA huggingface dataset:
Protein: RLMG_YERPE
Sequence: MSQLDLGTQSLELERFPPQENSNTLQAWEAADEYLLQNIDLSQIDGRPVLVFNDQFGTLACALHAYRPFSSSDSYMSQLATAHNLRLNHLDESAVTLLSSVDDLPEAPKLVVIKIPKALALLEHQLRALRRVVAPDTVIIAGAKSRDVHNSTLQLFEKILGPTKTTLAWKKARLIHCEVADIPLADAPETIDWPLPNTDYIIHNHANVFSRNNLDIGARFFMEILPYDVTGKIADLGCGNGVVGLIALEQNPLAEMLFVDESYMAVASSELNITVNRPQDLSRCEFMVSHGLAGVERESLQLVLCNPPFHQQHAVSDHVAWQMFCDAKRCLKAGGELMIVGNRHLDYFHKLKRLFGNCETLDSNQKFMVLKSVKQASSRSEGGGSGSLDMSYSDF
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BHMT1_PIG
Sequence: MAPVGDKKAKKGILERLNSGEVVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFRQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHGVTPGQCAVRLVKAGASIVGVNCHFDPTISLQTVKLMKEGLQAAGLKAHLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATR
What is the function of this protein?
Involved in the regulation of homocysteine metabolism.  Converts betaine and homocysteine to dimethylglycine and methionine, respectively.  This reaction is also required for the irreversible oxidation of choline.
What are the official names of this protein?
Betaine--homocysteine S-methyltransferase 1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress.
Protein: TRPE_CORGL
Sequence: MSTNPHVFSLDVRYHEDASALFAHLGGTTADDAALLESADITTKNGISSLAVLKSSVRITCTGNTVVTQPLTDSGRAVVARLTQQLGQYNTAENTFSFPASDAVDERERLTAPSTIEVLRKLQFESGYSDASLPLLMGGFAFDFLETFETLPAVEESVNTYPDYQFVLAEIVLDINHQDQTAKLAGVSNAPGELEAELNKLSLLIDAALPATEHAYQTTPHDGDTLRVVADIPDAQFRTQINELKENIYNGDIYQVVPARTFTAPCPDAFAAYLQLRATNPSPYMFYIRGLNEGRSYELFGASPESNLKFTAANRELQLYPIAGTRPRGLNPDGSINDELDIRNELDMRTDAKEIAEHTMLVDLARNDLARVSVPASRRVADLLQVDRYSRVMHLVSRVTATLDPELDALDAYRACMNMGTLTGAPKLRAMELLRGVEKRRRGSYGGAVGYLRGNGDMDNCIVIRSAFVQDGVAAVQAGAGVVRDSNPQSEADETLHKAYAVLNAIALAAGSTLEVIR
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 1, AS, ASI.
What is the protein family that this protein belongs to?
Belongs to the anthranilate synthase component I family.
Protein: LGT_PEDPA
Sequence: MNLTLGALNPIAFNLGGIQVHWYGIIIASAVVLATILAVQEAKRRRIDPDSIYDLILWALPVAIITARMYYVIFEWGYYQNHVDEIVRVWDGGIAIYGALIGAGIVVYLFCRANWIPVWLMLDIIAPVLIMAQGIGRWGNFMNQEAFGRITSLTFLQSLHLPHFIIQQMLIDGAYRQPTFLYESLWDILGFIVLMSLRHKKHLFKQGEVFLSYVIWYAFGRFFVEGMRTDSLMLLGIRVSQWLSVILFIGAIGILVFRRKSMRERLPDYLEGNQLSPK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ALBA_NANEQ
Sequence: MPEVFIGKKPLTNYVMAVVMQFMQGANEVVIKARGRNISRAVDVAERVRKRFLAGQVDVGDIKIDSEEVVDPATGQKRTVSTIEIKLVKK
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
What are the official names of this protein?
DNA/RNA-binding protein Alba.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: NDHJ_NANDO
Sequence: MQGRLSAWLVKHGLVHRSLGFDYQGIETLQIKPEDWHSIAVISYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIQYGVDQPEEVCIKVFAPRRNPRIPSVFWIWKSADFQERESYDMLGISYDNHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: ISCS_ACTSZ
Sequence: MKLPIYLDYAATCPVDERVAEKMMNYLTIDGVFGNPASRSHKFGWQAEEAVDIARNQIADLIGADSREIVFTSGATESDNLAIKGAAHFYQTKGKHIITCKTEHKAVLDTCRQLEREGFEVTYLSPKCDGLIDLDEFKAAIRPDTILASIMHVNNEIGVIQDIRAIGEICRAHKIIFHVDATQSVGKIAINLAELSVDLLSMSGHKLYGPKGVGALYVRRKPRIRLEAIIHGGGHERGMRSGTLPVHQIVGMGEAYRICKEEMATEMPRLKALRDRLYNGLKDIEETYVNGSMEHRVDSNLNISFNYVEGESLMMALRDIAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFTVGRYTTEEEIDYTIELVKSAVKKLRELSPLWDMFKEGVDMSKIEWSAH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUCS_MYCGI
Sequence: MRLVIAQCTVDYVGRLTAHLPSARRLLLFKADGSVSVHADDRAYKPLNWMSPPCRLVEQADGETPVWVVENKAGEQLRITVEAIEHDSSHELGVDPGLVKDGVEAHLQALLAEHVELLGAGYTLVRREYMTPIGPVDLLCRDEQGRSVAVEIKRRGEIDGVEQLTRYLELLNRDSLLAPVAGVFAAQQIKPQARTLATDRGIRCLTLDYDKMRGMDSDEFRLF
What is the function of this protein?
Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
What are the official names of this protein?
Endonuclease NucS.
What is the protein family that this protein belongs to?
Belongs to the NucS endonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEX8_ADE03
Sequence: RDAQAEVQMTNAGVQLAGGSALCRHRPQQSIKRLVIRGRGIQLNDESVSSSLGLRPDGVFQIAGCGRSSFTPRQAVLTLESSSSQPRSGGIGTLQFVEEFTPSVYFNPFSGSPGQYPDEFIPNFDAISESVDGYD
What are the official names of this protein?
Hexon-associated protein, Protein VIII, pVIII.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae pVIII family.
Protein: GCSP_FLAAN
Sequence: MERARRLAMLGRLVSQTKHNPSISSPALCSPSRYVSSLSPYVCGGTNVRSDRNLNGFGSQVRTISVEALKPSDTFPRRHNSATPEEQTKMAEFVGFSNLDSLIDATVPKSIRLDSMKYSKFDEGLTESQMIAHMQDLASKNKIFKSFIGMGYYNTSVPTVILRNIMENPGWYTQYTPYQAEIAQGRLESLLNFQTMITDLTGLPMSNASLLDEGTAAAEAMAMCNNIQKGKKKTFIIASNCHPQTIDICKTRADGFDLKVVTSDLKDFDYSSGDVCGVLVQYPGTEGELLDYSEFIKNAHANGVKVVMASDLLALTILKPPGELGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRMMPGRIIGVSVDSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYGVYHGPEGLKTIAKRVHGLAGTFAAGLKKLGTVQVQDLPFFDTVKVTCADSKAIAEEACKHKMNLRIVDKNTITVAFDETTTIEDVDTLFKVFALGKPVPFTAASIAPEVQDAIPSGLVRETPYLTHPIFNMYHTEHELLRYISKLQSKDLSLCHSMIPLGSCTMKLNATTEMMPVTWPAFADIHPFAPTEQAQGYQEMFKNLGDLLCTITGFDSFSLQPNAGAAGEYAGLMVIRAYHMARGDHHRNVCIIPVSAHGTNPASAAMCGMKIITVGTDSKGNINIEELRKAAEANKENLSALMVTYPSTHGVYEEGIDEICKIIHDNGGQVYMDGANMNAQVGLTSPGWIGADVCHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPYLPSHPVVPTGGIPAPEESQPLGTIAAAPWGSALILPISYTYIAMMGSQGITNASKIAILNANYMAKRLENHYPILFRGVNGTVAHEFIVDLRPLKTTAGIEPEDVAKRLIDYGFHGPTMSWPVPGTLMIEPTESESKAELDRFCDALISIRQEIAEIEKGNVDFNNNVIKGAPHPPQLLMADKWTKPYSREYAAYPAPWLRAAKFWPTTCRVDNVYGDRNLICTLQPPQEYEEKAEATA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), mitochondrial, Glycine cleavage system P protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NPIIC_ASPFU
Sequence: MKITALASAILAVAQGALALPARAPALDITLSQVNNTRIKAVVKNSGTEKITFVHLNFFNDPSPVKKVSLYRNATEVEFTGIKQRLRSDGLSNDALTTLAPGATYEDEFDIASTANLTQGGPVTVRTQGFVPIAMNNKIAGYIPYSSNELELEVDAEKAVAVPASIKPLDRRTKITSSCTGNRATVLNTALRNAASIASKAADAASSGSSALFTEYFKSTSGNIRSAVAARLKAVASEASMNGGGSTTYYCSDPYGYCDSNVLAYTLPSTNEVVNCELFYTLQEVTNDCHGQDQATTIIHEFTHAPGVYPPGTEDLGYGYSAATALSTSNALNNADSYALFANAVYLNCQGQTGGQTTWDGYSQPGQTEPGTQTMWDGYSQPGQTEPGTQTMWDGYSQPGQTEPGTQTTWDGYSQPGQIEPCTQTMWDGGSEPGQTEPDAQTMWDNFYQA
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Shows high activities on basic nuclear substrates such as histone and protamine.  May be involved in virulence (By similarity).
What are the official names of this protein?
Neutral protease 2 homolog AFUB_070680, Deuterolysin AFUB_070680.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YR804_MIMIV
Sequence: MYNNYTDDNLVTSSTNYLIIDSISDSISDSISDSTNNLIHNPENNFEKKYTNIITKGKNYTKSTDFIVKIVYFEVIDGVCDRNKSSKKIVGKFIHGGIINTEIPVRSKIRKIILETICEDIKESCKYRFDYYHYKSNPKKIIIKFKNGELYPIIKINSKNATYRTTKKIKHRQTKYVNKKNQCILF
What are the official names of this protein?
Uncharacterized protein R804.
Protein: RL19_TREPA
Sequence: MSCHLIQQIENQQRKEPAETFRVGDTVRVHFKIVEGKTERIQAYEGLVLCFKNSGVRRTFTVRKNSYGVGVERIFPLHSPRIERVDVVRAGKVRRAKLYYIREKIGKAARIKARIVKKPSPSA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RECF_RICPR
Sequence: MKNIFLHSLTLENYRNFKNLELKTDNTPIILTGENGSGKTNILEAISLFYPGRGLRSSKLTDICKTSEDYCKVKTLLQSKLGLAELSTHIKRSSNRRITEYNASKIANNELSKFTNMVWLTPQMEGIFTSSSTDRRKFLDRIVYNFDTKHAALLNKYEYYMHERNKILAEDIRDNNWLKIIEEKMADISNNIANNRLKTIRFIQQAIDDIENEFPKADLSIDGIIEQKILNVEGDIVNFIITELYKTRSKDKLLGRTSFGIHKSDFLVKHQKKNILAKFCSTGEQKAILIAIILAEINSTIKLTKITPILLLDEIFVHLDDKRRQYLMGFFNALNIQLWVTATDLDGIENFANKAQLIKL
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP (By similarity).
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TI441_ARATH
Sequence: MAIRKIIRDLLITKQPLLRQLFHQRVLRANARSEFLPAIGYTSHRRFSVFTEFSKNIRGEAHSNPEFERTVKELKERTEEFKGVTEDLKVRTKQTTEKLYKQADGVWTEAESAAKKVSSSVKDKLSAASEEVKESFKLGKEENAESASSSGTRASQGEKQQSGSTEELHTFFAKFKSSLSSPKVSEVFYRLKEAKPFDIVKQALDIVKDELRGNPSRKKFLEHTPPPPFTGERSMRTEMVVTQTKQSKLQQKWESFREKMQGSPVFKRLSGMSEPVVNKSQEIAEDVREIWETSDNPIVHKIQDMNEKFLKETDSASTYKEIRSRDPSFSLPDFAAEIEEVIKPVLNAYSEGDVETLKKYCSKEVIERCTAERTAYQTHGVLFDNKLLHISEVSVSVTKMMGDSPIIIAKFQTQEIYCVRDENGEIQEGGQDTIHTVYHEWAMQQVETTELGEDAIYPIWRLREMCRNGVQALI
What is the function of this protein?
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM44-1.
What is the protein family that this protein belongs to?
Belongs to the Tim44 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: Y1898_MYCTU
Sequence: MSVLVAFSVTPLGVGEGVGEIVTEAIRVVRDSGLPNQTDAMFTVIEGDTWAEVMAVVQRAVEAVAARAPRVSAVIKVDWRPGVTDAMTQKVATVERYLLRPE
What are the official names of this protein?
UPF0045 protein Rv1898.
What is the protein family that this protein belongs to?
Belongs to the UPF0045 family.
Protein: CREC_EMENI
Sequence: MFVLPPPPPRYTVPVAYAAGASNGMAVPIVETNNIITHPEKGCPLQVGEGTYQLQDDLHLATPPPHPSEAPIINPNPLATVPNPPTSGVKLSLISLGLRNKTAFPSKVQVTARPFGDGNSALAAAPVKDPSKKRKPKNNIIKSSSSFVSRVIIHEATTKRLNDRDPEGLFAFANINRAFQWLDLSSKHKDEPLSKILFTKAHMISHDVNEITKSSAHIDVIMGSSAGDIFWYEPISQKYARINKNGIINSSPVTHIKWIPGSENFFIAAHENGQLVVYDKEKEDALFIPELPEQSAESVKPSRWSLQVLKSVNSKNQKANPVAVWRLANQKITQFAFSPDHRHLAVVLEDGTLRLMDYLQEEVLDVFRSYYGGFTCVCWSPDGKYIVTGGQDDLVTIWSLPERKIIARCQGHDSWVSAVAFDPWRCDERTYRIGSVGDDCNLLLWDFSVGMLHRPKVHHQTSARHRTSLIAPSSQQPNRHRADSSGNRMRSDSQRTAADSESAPDQPVQHPVESRARTALLPPIMSKAVGEDPICWLGFQEDTIMTSSLEGHIRTWDRPRENISDNYGDQKSSETLGTGKEAGHPASSMGSL
What is the function of this protein?
Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression.  CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.
What are the official names of this protein?
Catabolite repression protein creC.
What is the protein family that this protein belongs to?
Belongs to the WD repeat creC family.
Protein: Y2216_TOLAT
Sequence: MFGKGGMGNLMKQAQMMQERMQKMQEEVAKMEVTGESGAGMVKITITGSHNVRRVTIDPSLLQDDDQEMLEDLIAAAFNDAVRRAEEQNKAKMAEITGGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Tola_2216.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: GLT12_DROME
Sequence: MEVFASVLNCCFKYIVLPVWIFIVLLLLHRDLSSWDGLMGPLSHPGLGENGSASYLSVPSWEIDEYTQGWRYYLYNSWLAERIPLRRSLPDLRDHRCQKLEYDEDSDEMKPASIIMIFRNEQLVVLLRTLHSLVERTPKYLYIELILVNDHSDTDFWNDKLSLIFFDNYVHRYIHPKARILHLPEQVGLIKARNLAASEAKAENLVFVDAQVEFTNGWLSPLLDTIAEQSYTLATPILDNLDEQTLAYQRSIERRGMYDWSLTRREVPLSRARRSHLPWPYEVAAVRTSVFAIPAVWFQDISNFDNNLRGFGAAELELSFKVWCTGGRIVQVPCSRVGHLQPKDEDYLKRYGDLHKMGEQKSRNLKRIIEVWTGDLKSAIYKYQPHLLNISEGDLNEPRKLYKQNECQSFKEFINDITPGLNHVAALNRTDYASGHVKTLEFPKKCLTINAKSQNLFLERCSTNNTLQNWTLTYVKDLRVAGNICAEVRPNLRLGYSFCHSLGGRQSWHYDSVSNQLMSNTKCLEFTDELNIFLAICDAANGKQRWILDNINLSVMQSANILV
What is the function of this protein?
Probable inactive glycosyltransferase.
What are the official names of this protein?
Putative inactive polypeptide N-acetylgalactosaminyltransferase 12, pp-GaNTase 12, Inactive UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12, Inactive protein-UDP acetylgalactosaminyltransferase 12.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: HNMT_XENTR
Sequence: MDSGLRSLLSDHSRYVESFRLFLLNSTEHQCMQRFIDTQFPHIVSSIGKDKSVIDILGIGSGSGEIDLQMIGKIQSRHPGVAISNQIVEPSAEQIIGYKERVAKAPNLGAVSFSWHRQTSSEYERQVNEEKQMRSYDFIHMIQMLYYVKDVPATLRFFKSCLAPNGKLLIILVSGNSGWSMLWKKHGPQLPLNDLCLYVTAGDIAQMLSSMGARFQSYELPSDMDITECFIEGDRNGEMLLDFLTETCDFKRNAPADLREQILCDLKSPECSTTRDGKVIFNNNLSVIVVERD
What is the function of this protein?
Inactivates histamine by N-methylation.  Plays an important role in degrading histamine and in regulating the airway response to histamine.
What are the official names of this protein?
Histamine N-methyltransferase, HMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_ACISJ
Sequence: MTQTLSSQDPQAPAAPPMPGAAGSAPADVAHPKGIKSYVRRAGRTTTGQAKALEELGPRYVLDYAPALLDATAAFGRSAPLVLEIGFGMGEATAHIARVRPQDNFLCCEVHEPGVGALLKRIGEQDIHNIRILQHDAVEVLEHMLAPGALDGVHIFFPDPWHKKRHNKRRLIQPPLVAQLAARLKPGGYIHCATDWQPYAEQMLEVLSAEPLLSNTAEGYAPQPDYRPLTKFENRGMRLGHGVWDLVFTRR
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: KAD_MYCSK
Sequence: MRIVLLGPPGAGKGTQAAKLADKLGVPHISTGDLFRDNITNETELGVEAKRYLDAGDLVPSSLTNALVEDRIDQDDAKNGFILDGYPRSVEQAEALGDMLAARNLSLDAVIEFRVSEDELLSRLKGRGRADDTEEVILNRMKVYRDETAPLLDHYRAELKTVDAVGSLDEVFARALQALGR
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AK1_DICDI
Sequence: MQPVPSDPNYGLLRSLFQDPNNQCCAECNSANVPYVCIKLGVFICPTCAHFLSTLGFKVRPIMGSSFSEEDISRLQSIGNLVSKQFWLARWTPMDIVMPPPEDPNLESFLRLKYIEKRWTSSLSTSDGFSSPNNNNTSNVNNINNNSNHNNNINNNNNNINNNNNNNINNNNNIINNFSNINNISNGMNNISLNNINNNNNNNNHYNGNDIGIPIVHKTQSQPQPQPQPQPQPQSQGFSPFNSPRSSPKPGRHHLIDDLISFNPTPVNNSNNNNNNNNNNNNGNNGNPLKFSGGIPQNNNNNNNNNTTTTTTTTNNNNKVPFDPFSPIKTFSESGEYQNTNGNQQLSGSGNSLIDILSHPTQSKSPSPSGTPHSLSPQHHSSDFKVHLIDIPTTQQQLQQQQLQLQQQLQQQLQQQQQQQQQQQQQQQSPISNPFTSNNNSNSEPLVSILDKHEDLHNHHHHQQQQHHKQQQQQQQQQQNGNNSPLAQFNQIQQQQINNNNPFVEEKQPHQHPHHLQHHRHHSTSSINHGSNGDLASISLTLLTPSPSPSPSFNYSGGVSSAPNNSLNNSCNGNNNLNNGMLNFSNLNIGGSTSSACSTNSSSNITIANNINSSNNINIINNQNNQNNNNNNNTNNVMISPSPSPNPFLPTPTSTNQNNHIITPIPVNPFTDNLQLNSNNIRQHPQQMYIQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQMQQQQQQQMQQHYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHINLSSSAPLQSVNHSPIPLQPQHSSSQYMNQQGYQVYPNVGNQPQSPQQIQPQPLQQQIFQQVQQQQPQIPQQSPQPLQSSTDEDQSVLEVLNLKKLFDMNMMDKEEFEHRRRQIIDNLTKTTSPIHQQPPQPPQPVLPVSAPAQVPQPHPPQQQNGPTVPQQQQQQQQQQQQQQQQQQQQQQQQQPIPQPSSSSPTPDARLTGTERVIRHRFDAKLGKWVQTATIVITEPTPFAEGAMRKAFRMKDLSAEGPSSQMVAKLFKDSNEDRMVYFKDVEMQTYSKEIAERFNLKSPPKKIDFVPAFVMELVERQGKPFCAVEYFIEGKYEKHNNNFGYKNDYDRNTPQAFSHFSYEDSGCQLIVVDIQGVGDVYTDPQIHSADGQGFGKGNLGIEGIKRFFSTHQCNPICHYLGLSSVNPKPANDESGTMPRPPSIGQSYVRPSAFPPNLQQSFSFNFPPLKDHHVLEQLNQQQQHLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQNQQQNQQQQQQQQQQQQQQQNGHPPPQTPLPPTPQQKDKPKIEVFGDILRKLVS
What are the official names of this protein?
Alpha-protein kinase 1, AK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
Protein: RUVB_TROWT
Sequence: MPLDILQNRNNLLDVTSDEKQTEGALRPKLLAEFVGQNKVKNQLALLIQAAKIQGRVTDHALLAGPPGLGKTTLAMIVAAECGVSIRMSSGPAIQHAGDLAALLSSLLPGELLFIDEIHRMSRVAEEMLYLAMEDFRIDIMVGKGPGATSVPLELSPFTLVGATTRAGLLPGPLRDRFGFTARLDFYSPEELLQVLIRSARLMEIQYYDDALESIAVRSRGTPRVANRLLRRTRDYLLVSNSSEILSKEIALKAMDVYEVDSLGLDRLDRAVLHAIFDRFSGGPVGIKTLSAYLGEEAETIENSIEPFLVRQGLLVRTPRGRQITDLARKHMGFKEDLSGFELYL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: TNFA_PERLE
Sequence: MSTESMIRDVELAEEALPKKAWGPQNSSRCLCLSLFSFLLVAGATTLFCLLNFGVIGPQREEKFPNNLPIIGSMAQTLTLRSSSQNSSDKPVAHVVANHQVDEQLEWLSRGANALLANGMDLKDNQLVIPADGLYLVYSQVLFKGQGCSSYVLLTHTVSRFAVSYEDKVNLLSAIKSPCPKETPEGSELKPWYEPIYLGGVFQLEKGDRLSAEVNLPKYLDFAESGQVYFGVIAL
What is the function of this protein?
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
What are the official names of this protein?
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted. SUBCELLULAR LOCATION: [C-domain 1]: Secreted. SUBCELLULAR LOCATION: [C-domain 2]: Secreted.