PharMolix/UniProtQA huggingface dataset:
Protein: ASSY_PARP8
Sequence: MSTILESLPTGQKVGIAFSGGLDTSAALHWMRLKGAVPYAYTANLGQPDEDDYDSIPRRATEYGAEGARLIDCRAQLVAEGIAALQSGAFHISTAGVTYFNTTPIGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQTFIDELGGRAEMSEFMRQSGFAYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVQIAKEEVTVRFEEGQPVALNGKTFPNAVELLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLFAAYERLVTGIHNEDTIEQYRESGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAITGEVTLELRRGNDYSILSTKSPNLTYQPERLSMEKVASTFSPRDRIGQLTMRNLDITDTRDKLRVYSQVGLLAPGEASALPQIKGDKE
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOTC4_HUMAN
Sequence: MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAPPANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGSPQLDCGPPALQEMPINQGGEGKK
What is the function of this protein?
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.  Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.  Affects the implementation of differentiation, proliferation and apoptotic programs.  May regulate branching morphogenesis in the developing vascular system (By similarity).
What are the official names of this protein?
Neurogenic locus notch homolog protein 4, Notch 4, hNotch4.
What is the protein family that this protein belongs to?
Belongs to the NOTCH family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Notch 4 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
Protein: RS18_CLOB1
Sequence: MAGREGGRRQRRTKRKVCTFCAEKSEAIDYKDINKLRKFVTERGKILPRRISGNCAKHQRELTRAIKRARNIALLPFTTE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: SRP19_METKA
Sequence: MAETPTVKLKGKDRIVVWPAYFDADRSRSEGRKVPKRLAVRNPRLTELRHIAEKLGLNPKVQRDKRYPKRWWDDKGRLIVDKVESKRKTLLMIAEKLKERRES
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_SHESW
Sequence: MVKKKSSKAAPATIARNKRATFEYRFEEKMEAGLSLMGWEVKSIRMGKVNLSDCYVFLKNGEAFMHGCTIIPLNTASTHVVCDPLRLKKLLLSRKELDKLAGLVERQGYSIIPISMYWRKGAWVKVEIGLGKGKKDHDKREDTKAREWEVEKARVMKKEKTHG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PDCL3_RAT
Sequence: MQDPNADTEWNDILRKKGILPPKESLKELEEEEEGKEEQRLQQSVVKTYEDMTLEELQENEDEFSEEDERAIEMYRQQRLAEWKATQLRNKFGEVLEISGKDYVQEVTKAGEGLWVVLHLYKQGIPLCSLINHHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTVFVYREGDIKAQFIGPLVFGGMNLTIDELEWKLSESGAIKTELEENPKKAIKDVLLSSVRDPVPMRRDSDSEDD
What is the function of this protein?
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (By similarity).  Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity).  Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (PubMed:27496612).  Modulates the activation of caspases during apoptosis (By similarity).
What are the official names of this protein?
Phosducin-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the phosducin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Protein: NRAM6_ORYSJ
Sequence: MAPLPAAATATASSAATPADDEAHSLLPSTPSNEEDDDDLEERAYEATEKVIVSISDFPDADDDEEESGLATSTAASGIPPFSWRKLWLFTGPGFLMSIAFLDPGNLEGDLQAGAVAGDTLLWLLLWATSMGLLVQLLAARVGVATGRHLAELCRDEYPSWARRALWLMAEVAMVGADIQEVIGSAIAIKILSRGFLPLWAGVVITALDCFIFLSLENYGVRKLEAVFAILIATMAVSFAWMFTDTKPNMKNLFIGILVPKLSSRTIRQAVGVVGCVIMPHNVFLHSALVQSRKIDPNKEHQVREALRYYSIESTIALAVSFMINLFVTTVFAKGFYGTKEAGNIGLENAGQYLQEKFGGGFFPILYIWGIGLLAAGQSSTITGTYAGQFIMGGFLNLKLKKWIRSLITRSFAIVPTIIVALFFDKSDSLDVLNEWLNVLQSIQIPFALIPLITLVSKEKVMGVFKIGRNTQAVTWTVATLLITINGYLLLDFFSSEIRGLLSGSILCVAVLAYASFVLYLILRGTELPNQIITTIRKSFS
What is the function of this protein?
Probable metal transporter.
What are the official names of this protein?
Metal transporter Nramp6.
What is the protein family that this protein belongs to?
Belongs to the NRAMP (TC 2.A.55) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYT_SHESW
Sequence: MPVITLPDGSKREFAHAVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSIITAKDEEGVEILRHSCAHLLGHAIKQMWPETKMAIGPVIDNGFYYDIDLEHKLTQDDIEALEKRMLQLAKTNYDVVKRVVSWQEARDTFAARGEEYKIAILDENISKDATPALYHHEEYTDMCRGPHVPNMRFCQHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLTRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMDRVLWERSGHWDKYSEAMFTTSSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTDDQVQEEVSACIQMVYDTYSTFGFENIVVKLSTRPEKRIGDDAMWDRAEEALKQALRANNIEFTLLPGEGAFYGPKIEFTLHDCLDRAWQCGTVQLDYALPNRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPMQVVVMNITDKQADYVQEIVKFFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENKEVAVRTRDGIDLGKMRLEDFATKIHQQISLRSLKLLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETB_BURP6
Sequence: MSVYGLQRLYIAGAHADATSGKTFDTFDPATGELLARVQQASADDVDRAVASAREGQREWAAMTAMQRSRILRRAVELLRERNNALAELEMRDTGKPIAETRAVDIVTGADVIEYYAGLATAIEGLQVPLRPESFVYTRREPLGVCAGIGAWNYPIQIACWKSAPALAAGNAMIFKPSEVTPLSALKLAEIYTEAGVPAGVFNVVQGDGSVGALLSAHPGIAKVSFTGGVETGKKVMSLAGASSLKEVTMELGGKSPLIVFDDADLDRAADIAVTANFFSAGQVCTNGTRVFVQQAVKDAFVERVLARVARIRAGKPSDPDTNFGPLASAAQLDKVLGYIDSGKAEGAKLLAGGARLVNDHFASGQYVAPTVFGDCRDDMRIVREEIFGPVMSILSFETEDEAIARANATDYGLAAGVVTENLSRAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQVELGRYQPVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: GATA_STAEQ
Sequence: MSIRFESIEKLTELIKNKEIKPSDVVKDIYAAIEETDPTIKSFLALDKENAIKKAEELDELQAKDQMDGKLFGIPMGIKDNIITKDVETTCASKMLEGFVPIYESTVMNKLHDENAVLIGKLNMDEFAMGGSTETSYFKKTLNPFDHTAVPGGSSGGSAAAVAAGLVPFSLGSDTGGSIRQPASYCGVVGMKPTYGRVSRFGLVAFASSLDQIGPITRNVKDNALVLEAISGVDANDSTSAPVDDVDFTSDIGKDIKGLKIALPKEYLGEGVSEEVKTSVKEAVETLKSLGAEVDEVSLPNTKYGIPSYYVIASSEASVNLARFDGIRYGYHSKEAQSLEELYKMSRSEGFGEEVKRRIFLGTFALSSGYYDAYYKKSQKVRTLIKNDFDKVFESYDVVVGPTAPTTAFNIGEEIDDPLTMYANDLLTTPVNLAGLPGISVPCGQSNGRPIGLQLIGKPFDEKTLYRVAYQFETQYNLHDAYENL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: RUVB_BIFAA
Sequence: MKRTIMTNTDTFEQPNTGANEESLRMVSAAPVGNEPVSDEELRPHILEGFIGQPRLKAQLQLFLDAARKRDVPPDHILLAGPPGLGKTTLAMIVANELEVPIRVTSGPAIQHAGDLASILSSLDAGEVLFIDEIHRLPRAAEELLYIAMEDFRVDVMVGKGPGASSIPLTLPRFTVIGATTREGMLPSPLRARFGFTAHLDFYPHEELEKLIERSSAVLGIQLEDGAARQLAMRSRGTPRIANRLLRRVRDWAIVHDLESVRPDDVKEALALYQIDTEGLDRLDIAVLKAIVTNFNGGPVGLNNLAAMVGEESETVETVCEPYLVREGFLIRTPKGRVATRKAWEHLGITPDESAYDVNEMS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: TPIS_SCYPA
Sequence: MANQRKFFVGGNWKMNGDKAAIDGIISFMKGPLNADTEVVVGCPQCYLMYTREHMPANIGVAAQNCYKTAKGAFTGEISPAMIKDCGCEWVILGHSERRNVFGEPDQLISEKVGHALEAGLKVIPCIGEKLEERESNRTEEVVFAQMKALVPNISDWSRVVIAYEPVWAIGTGKTATPEQAQDVHAKLRQWLRDNVSPQVAESTRIIYGGSVSAGNCKELAKTGDIDGFLVGGASLKPDFVTIINARA
What is the function of this protein?
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
What are the official names of this protein?
Triosephosphate isomerase, TIM, Allergen Scy p 8, Methylglyoxal synthase, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSF5_MOUSE
Sequence: MEEALLSTPINPNNFPAKLWRLVNSPRYRSIRWDGRGEGLLIDQPLFEAELLSPPGPGAGGAGGAGSSGGGGGSGVGAAGAEPELFKTTNFTSFIRQLNLYGFRKVVLGGPGAAGPGPGPGAGGPAGDGPLHHFHSPHFRRDQPQLLVHLKRLTSANKAKLAAGLEVPCRPPNRFQRLLITSASASASASTSPLQHQDPPPQPAGPRPEQHGPVAVGQFHRSFRRDNLSPYSYVSTSSHNHSAFPLKGLDRTPIPPRTWQNSLGMHPGQVETSPTFSDKGVPFPVLQRFPTEVTYTLQPSATSVHVQQGPQTMVSSSQKYSNYTPSAQYSQAYYPTAVLQCCSPPTHMDALSSCVTPTASSYAHCNYFQNPPMQSSYPVEFLPSNWPCSATDENKKTEVNLEAVFQIVDELHSSPKLEMVKVEPVETQCPSSQANRGQHILPNANSSNPSSTSQASQLEPLTPVGSDITSFVVGTEQAITCSLPQSPEYIYTIHTAQPLENSTMQESATIQQTHVKLKEQLNHNPSPSSVVFVQEGLPFSTPQVDSSIKCQTNPSENILPSEQMGFLISEMGPANKSTKDTGLSTPARYRERRSNSQGKSPDLHLLVDVACKQEHFPKEEELKE
What is the function of this protein?
May act as a transcriptional factor.
What are the official names of this protein?
Heat shock factor protein 5, HSF 5, Heat shock transcription factor 5, HSTF 5, Protein expressed in male leptotene and zygotene spermatocytes 220, MLZ-220.
What is the protein family that this protein belongs to?
Belongs to the HSF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MOAE_YERPE
Sequence: MMENTRIRVGAEAFSVGDEYTWLSQCDEDGAVVTFTGKVRNHNLGASVSALTLEHYPGMTEKALTEIIADARSRWSLQRVSVIHRVGPLFPGDEIVFVGVTSAHRSMAFEAAEFIMDYLKTRAPFWKREATVEGERWVESRDSDHIAAKRW
What is the function of this protein?
Converts molybdopterin precursor Z into molybdopterin.  This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group.  The sulfur is provided by MoaD (By similarity).
What are the official names of this protein?
Molybdopterin synthase catalytic subunit, MPT synthase subunit 2, Molybdenum cofactor biosynthesis protein E, Molybdopterin-converting factor large subunit, Molybdopterin-converting factor subunit 2.
What is the protein family that this protein belongs to?
Belongs to the MoaE family.
Protein: SLPI_SHEEP
Sequence: MKFSGLFPFLLLALGTLALWAVEGAENEALKAGACPPRKSAQCFGNEKPRCSSDWQCPHKKKCCLDTCGTECLDPVNITNPVKKKPGTCPVIHGQCLMLKPLNHCETDDQCIGALKCCKAMCGKVCLSPVKA
What is the function of this protein?
Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G.  Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L. major.  Down-regulates responses to bacterial lipopolysaccharide (LPS).  Plays a role in regulating the activation of NF-kappa-B and inflammatory responses.  Has antimicrobial activity against mycobacteria, but not against salmonella.  Contributes to normal resistance against infection by M. tuberculosis.  Required for normal resistance to infection by L. major.  Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity).  Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity).
What are the official names of this protein?
Antileukoproteinase, ALP, Secretory leukocyte protease inhibitor.
Protein: IEC3_SCHPO
Sequence: MASVKSFKRKYLKLRKSFDSVVLETEEIEQKIAEISEVYRRILLENAHLNDLLIDMNSTVLPTPPASPPGSPYWEAKPVSHTVFLESPSDVFTLEKPIASTHRWLSKLTALSKSTNSTLSTPKSFHSPLQSRGISPSSAQSSAAVSSSRKQKRKRTSEGPSERRARKK
What is the function of this protein?
Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
What are the official names of this protein?
INO80 complex subunit 3.
Protein: RS12_LACH4
Sequence: MPTINQLVRKGRHSKVTKSKSPALNYSYNSMKKESVFNPAPQMRGVATRVGTMTPKKPNSALRKYARVRLSNLIEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGALDTAGVDGRKQSRSKYGTKKD
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: VP7_ROT18
Sequence: MYGIEYTTILNSLILVVLLNYILKSVTRVMDYIIYRFLFVIVIVSLCAKAQNYGINLPITGSMDGAYTNTTDDKPFLTSTLCIYYPTIASNDLADPDWKNTVSQLFLTKGWPMGSVYFNEYVNIAEFSINPQLFCDYNIVLMKYESDLEMDMSELADLLLNEWLCNPMDVTLYYYQQTDEANKWISMGTSCTIKVCPLNTQTLGIGCLTTDTSSFETVAVNEKLVITDVVDGVSHKLDVTNVTCTIRNCKKLGPRENVAVVQIGGANILDITADPTTAPQTERMMRVNWKKWWQVFYTIVDYINQIVKVMSKRSRSLNSAAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: ISOA1_ARATH
Sequence: MDAIKCSSSFLHHTKLNTLFSNHTFPKISAPNFKPLFRPISISAKDRRSNEAENIAVVEKPLKSDRFFISDGLPSPFGPTVRDDGVNFSVYSTNSVSATICLISLSDLRQNKVTEEIQLDPSRNRTGHVWHVFLRGDFKDMLYGYRFDGKFSPEEGHYYDSSNILLDPYAKAIISRDEFGVLGPDDNCWPQMACMVPTREEEFDWEGDMHLKLPQKDLVIYEMHVRGFTRHESSKIEFPGTYQGVAEKLDHLKELGINCIELMPCHEFNELEYYSYNTILGDHRVNFWGYSTIGFFSPMIRYASASSNNFAGRAINEFKILVKEAHKRGIEVIMDVVLNHTAEGNEKGPIFSFRGVDNSVYYMLAPKGEFYNYSGCGNTFNCNHPVVRQFILDCLRYWVTEMHVDGFRFDLGSIMSRSSSLWDAANVYGADVEGDLLTTGTPISCPPVIDMISNDPILRGVKLIAEAWDAGGLYQVGMFPHWGIWSEWNGKFRDVVRQFIKGTDGFSGAFAECLCGSPNLYQGGRKPWHSINFICAHDGFTLADLVTYNNKNNLANGEENNDGENHNYSWNCGEEGDFASISVKRLRKRQMRNFFVSLMVSQGVPMIYMGDEYGHTKGGNNNTYCHDNYMNYFRWDKKEEAHSDFFRFCRILIKFRDECESLGLNDFPTAKRLQWHGLAPEIPNWSETSRFVAFSLVDSVKKEIYVAFNTSHLATLVSLPNRPGYRWEPFVDTSKPSPYDCITPDLPERETAMKQYRHFLDANVYPMLSYSSIILLLSPIKDP
What is the function of this protein?
Involved in the trimming of pre-amylopectin chains.  Accelerates the crystallization of nascent amylopectin molecules during starch synthesis.  ISA1 and ISA2 work exclusively together as a multimeric holoenzyme.  ISA1-ISA2 removes preferentially branches that are very close to other branches.  Promotes negative gravitropic responses in shoots by facilitating starch granules (statoliths) formation in hypocotyls (PubMed:34367195).
What are the official names of this protein?
Isoamylase 1, chloroplastic, AtISA1, Protein REDUCED GRAVITROPIC 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: AROE_GEOMG
Sequence: MDITGKTRVLGIIGWPVAHSLSPLMQNAALEAMGLDWIYVPFAVRPEDLASAVAGLRTLGVSGFNVTIPHKTAIIPLLDRITPEARLMGAVNTVKREGDDLVGYNTDGEGFIRSLAEDLGFVPAGRRILVLGAGGAARAAVASLARGGAATVMIANRSVARGEELVEAFQGVFGGTQFAAMPLDIPLINAEVQNFDLLVNTTSVGMGETAFEGLDISRMNPAASVYDMVYAPWETPLLAEASRGGRRCANGIGMLVAQGECALAIWTGMEPPPGIMRRRVLAALKR
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: TAL_CAMJR
Sequence: MKNFSLWCDFIENSFLDNEFLNLLSHGINGATSNPAIFKNAILNSPIYKDKILKLKEKKTKDIYEELAISDIQKAADKLAPLFYQKNDGFISIEIDPRLHDNTTLSLGEAKRLYSAIGKENIMIKIPATKASYEVMYELMKNGISVNATLIFSLEQSQKCFEALNAGLVEFRKNNIALKEQNTRTPQAVISIFVSRFDRLLNPKAKEQNRIGILNANLAYNNIYSKNEPNIRALFASTGVKGDDLPKDYYIKELLFENSVNTAPLDAIEAFKGKMHFKKPLMNFEIYTELNQIISQSEREKACNDLLSDGLEQFCIAFEDILKAL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGR_VIBVU
Sequence: MRPSEKQDNLVRAFKALLKEERFGSQGEIVEALKQEGFENINQSKVSRMLTKFGAVRTRNAKMEMVYCLPTELGVPTVSSSLRELVLDVDHNQALVVIHTGPGAAQLIARMLDSLGKSEGILGVVAGDDTIFITPTLTITTEQLFKSVCELFEYAG
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPSS2_METBU
Sequence: MTLDDAALKSFGFIERPTKNMINIDPLQTGGILTEDARRALVEWGDGYSICDNCGGVLDLIKKPPVQKFIHEALPEFLGVDEVRITHGARESKFAVMHAIAQEGDTVILDGLAHYSSVVAAQRARLEIRKVPHSEKPDYHIDPEAYGTAIEETISETGKAPALALLTYPDGNYGNLADAKKIASVCHEYDVPLLLNCAYSVGRMPVDAKELGVDFIAGSGHKSMASCGPIGVLGVNNDNGDYSDIIFRKSPTNKNKEIELLGCTARSATLMTMIASFPEVVKRTRNWGNEVADARWFSEKLETMGLIQMGQKPHNHDLMFFEAPNLYEISTRVKKGRYFLYKELKSRNIHGIKAGLTKFFKLSTFEVGRENLSYIVDSFDEIIKKYE
What is the function of this protein?
Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
What are the official names of this protein?
O-phospho-L-seryl-tRNA:Cys-tRNA synthase 2, Sep-tRNA:Cys-tRNA synthase 2, SepCysS 2.
What is the protein family that this protein belongs to?
Belongs to the SepCysS family.