PharMolix/UniProtQA huggingface dataset:
Protein: APOA1_PERMB
Sequence: MKAVVLAVAVLFLTGSQARHFWQQDDPQTSWDRVKDFATVYVDAIKDSGRDYVSQFESSALGQQLNLKLVDNWDTVGTTVGRLQEQLGPVTQEFWSNLEKDTDWLREEMNKDLEEVKKQVQPYLDQFQTKWQEEMEHYRQKVGPLGAELREGARQKLQDLQERLVPVGEDIRDRMRTHVDALRSNLSPYSDKMRERLAQHLAKLKDSTTLAEYRTKASNHLQTLSEKAKPALEDLRQGLTPMLESFRATIMGWIDETSKRLSTQ
What is the function of this protein?
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).  As part of the SPAP complex, activates spermatozoa motility.
What are the official names of this protein?
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: GGA2_YEAST
Sequence: MSHPHSHSIYLSELPVRKPQALGNPLLRKIQRACRMSLAEPDLALNLDIADYINEKQGAAPRDAAIALAKLINNRESHVAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPGHPPLRYSKIQRLILTAIEEWYQTICKHSSYKNDMGYIRDMHRLLKYKGYAFPKISESDLAVLKPSNQLKTASEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMKIMAGFKEDNAVQAKQAISSELNKLKRKADLLNEMLESPDSQNWDNETTQELHSALKVAQPKFQKIIEEEQEDDALVQDLLKFNDTVNQLLEKFNLLKNGDSNAASQIHPSHVSAPLQQSSGALTNEINLIDFNDLDEAPSQGNNNTNGTGTPAAAETSVNDLLGDLTDLSISNPSTANQASFGLGGDIVLGSSQPAPPVTTTNNSNNTLDLLGLSTPQSPTNSQAVNSSGFDLLMGFNPTTGTTTAPARTLVNQSPNLKIEFEISRESNSVIRIKSFFTNLSSSPISNLVFLLAVPKSMSLKLQPQSSNFMIGNAKDGISQEGTIENAPANPSKALKVKWKVNYSVNSTQAEETAVFTLPNV
What is the function of this protein?
May play a role in the regulation of membrane traffic through the trans-Golgi network.
What are the official names of this protein?
ADP-ribosylation factor-binding protein GGA2, Golgi-localized, gamma ear-containing, ARF-binding protein 2.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network.
Protein: TFDC2_DELAC
Sequence: MKNPRVHEIATAMIDAVRKVLVDHQ
What are the official names of this protein?
Chlorocatechol 1,2-dioxygenase 2, TfdCII.
What is the protein family that this protein belongs to?
Belongs to the intradiol ring-cleavage dioxygenase family.
Protein: RS12_CENSY
Sequence: MAKSPLGLFAGRVLKAKKKRQRWSISRYKRRELGLDRKANPMGGSPQARGIVLEKVGVEAKQPNSAVRKCVRVQLIKNGKSITAFLPRDGAMNFIDEHDEVHVEGMGATQGGAMGDIPGVRFKVFKVNGTSLHELVIGKKEKPRR
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ARL8D_ARATH
Sequence: MTLQPNLQAKEMELSLVGLQNSGKTSLVNVVATGEYSEDMIPTVGFNMRKVTKENVAIRLWDLGGQPRFRCMWERYCRAVSMIVYVVDAADTENLSVSRSELHDLLSNASLIGIPLLVLGNKIDIHGALSKEALTEEMGLSSVTSREVCCLMISCKNPTTIDQLTDWLVNHSKSKN
What is the function of this protein?
May play a role in lysosome motility.  May play a role in chromosome segregation.
What are the official names of this protein?
ADP-ribosylation factor-like protein 8d, AtARL8d, ADP-ribosylation factor-like A1B, AtARLA1B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Note=Localizes with microtubules at the spindle mid-zone during mitosis.
Protein: DPO4_PSE14
Sequence: MTQRKIIHIDCDCFYAAIEMRDEPELAGKPLAVGGSAERRGVIATCNYEARAYGVRSAMSSRHALKLCPDLTIVKPRMEAYKEASREIHTIFRDYTDLIEPLSLDEAFLDVSDAGHFSGSATRIAQDIRRRVSNQLHITVSAGVAPNKFLAKIASDWKKPNGLFVITPDQVEDFVASLPVTKLHGVGKVTADKLGRLGIVDCADLRGRSKLALVREFGSFGERLWSLAHGIDDRPVQNDSRRQSVSVENTYDTDLPDLAACLEKLPALLETLGNRMARMEGQYRPGKPFVKVKFHDFTQTTLEQSGAGRDLGSYEQLLAQAFARGAKPVRLLGIGVRLHDLRAAHEQLELFSQ
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5HT1A_CANLF
Sequence: MEGLSPRQGNNTTSSEGPFGTLGNATGISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKAERKGADARSGVSPAPQPRKSVNGEPGGREWRQGPGSQAGGPLCTNGAVRRGDDGAALEVIEVHRVGSSKEHLPLPCEAGAIPCAPASFEKKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIVRCKFCRRR
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores.  Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism.  Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior.  Plays a role in the response to anxiogenic stimuli (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, Serotonin receptor 1A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
Protein: NPC3_ARATH
Sequence: MVEETSSGGGSSASPIKTIVVLVQENRSFDHMLGWFKELNPEIDGVSESEPRSNPLSTSDPNSAQIFFGKESQNIDPDPGHSFQAIYEQVFGKPFSDESPYPDPKMNGFVQNAEAITKGMSEKVVMQGFPPEKLPVFKELVQEFAVCDRWFSSLPSSTQPNRLYVHAATSNGAFSNDTNTLVRGFPQRTVFESLEESGFTFGIYYQSFPNCLFYRNMRKLKYVDNFHQYHLSFKRHCKEGKLPNYVVIEPRYFKILSAPANDDHPKNDVVEGQNLVKEIYEALRASPQWNEILFVVVYDEHGGYYDHVPTPVIGVPNPDGLVGPEPYNFKFDRLGVRVPALLISPWIEPGTVLHEPNGPEPTSQFEHSSIPATLKKIFNLKSFLTKRDEWAGTLDAVINRTSPRTDCPVTLPELPRARDIDIGTQEEDEDLTDFQIELIQAAAVLKGDHIKDIYPFKLADKMKVLDAARYVEEAFTRFHGESKKAKEEGRDEHEIVDLSKGSTRHSTPKSFVQKLFSCLICDN
What is the function of this protein?
Possesses specific phosphatase activity toward lysophosphatidic acid (LPA) in vitro.  Does not show phospholipase C activity.  May play a role in signal transduction and storage lipid synthesis.  May be involved in brassinolide-mediated signaling in root development.
What are the official names of this protein?
Non-specific phospholipase C3.
What is the protein family that this protein belongs to?
Belongs to the bacterial phospholipase C family.
Protein: CREB_HYDVD
Sequence: MELARHSFQQPLNVAPSLSNVVNKTSVVLQQQSVIQPNQHQLQHQLQTMHDGGIDGKRREILARRPSYRRILDDLAGDGPVKMENYDDTGSSGESSPNGNNEEDINGINQSVSHQEKQYQSIHLNGIVSSVQGGENSLNQLHDSQPGDNQYIITTQGPDNKIQAYTIKGTLPIGLDNTSLASPHQLAEEATRKRELRLYKNREAARECRRKKKEYVKCLENRVAVLENQNKALIEELKSLKDLYCSKGD
What is the function of this protein?
This protein binds the cAMP response element (CRE), sequence present in many viral and cellular promoters.  Could regulate the transcriptional activity of genes involved in regeneration processes.
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein, cAMP-responsive element-binding protein, cAMP response element-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFTU_MYCBO
Sequence: MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLNETKAFDQIDNAPEERQRGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADAVDDEELLELVEMEVRELLAAQEFDEDAPVVRVSALKALEGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVINVNEEVEIVGIRPSTTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGVKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTNISVKLIQPVAMDEGLRFAIREGGRTVGAGRVTKIIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASPD_BURP6
Sequence: MRNAHAPVDVAMIGFGAIGAAVYRAVEHDAALRVAHVIVPEHQCDAVRGALGERVDVVSSVDALACRPQFALECAGHGALVDHVVPLLKAGTDCAVASIGALSDLALLDALSNAADAGGATLTLLSGAIGGIDALAAARQGGLDEVRYIGRKPPLGWLGTPAEAICDLRAMAAEQTIFEGSARDAAQLYPRNANVAATVALAGVGLDATRVCLIADPAVTRNVHRIVARGAFGEMSIEMSGKPLPDNPKTSALTAFSAIRALRNRASHCVI
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
What are the official names of this protein?
L-aspartate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: TSH3_RAT
Sequence: MAAYVSDELKAAALVEDDIEPEEQVADGEPSAKYMCPEKELSKACPSYQNSPAAEFSSHEMDSESHISETSDRMADFESSSIKNEEETKEVQVPLEDTTVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSENNGGGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQNRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPAARKKPSLELELPSSPDSTGGTPKATLSDASDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIMETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASVSPKLTVEIKKEVDKEKAVLDEKPKEKEKASEEEEKYDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTKTQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEPDSKLSPPKRATPSPCSSEQSEPIKMEASSGSGFKSQENSPSPPRDVCKEASPSAEPVENGKELVKPLSGGSLSGSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPPLQAKKAEHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSGLLSPTSTSPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINNQIAQTKSPSEKMVTSSPEEDLGTTYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLFVSELEKQ
What is the function of this protein?
Transcriptional regulator involved in developmental processes.  Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4.  TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2.  Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).  Regulates the development of neurons involved in both respiratory rhythm and airflow control.  Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth.  Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes.  Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity).  Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).
What are the official names of this protein?
Teashirt homolog 3, Zinc finger protein 537.
What is the protein family that this protein belongs to?
Belongs to the teashirt C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cell projection, growth cone. Note=Colocalizes with APBB1 in the nucleus (By similarity). Colocalizes with APBB1 in axonal growth cone.
Protein: PARVA_MOUSE
Sequence: MATSPQKSPLVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSEFQEEGMNAINLPLSPISFELDPEDTLLEENEVRTMVDPNSRNDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKNLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE
What is the function of this protein?
Plays a role in sarcomere organization and in smooth muscle cell contraction.  Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract.  Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development.  Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis.  Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.
What are the official names of this protein?
Alpha-parvin, Actopaxin.
What is the protein family that this protein belongs to?
Belongs to the parvin family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions.
Protein: EHD1_HUMAN
Sequence: MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE
What is the function of this protein?
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis.  In vitro causes vesiculation of endocytic membranes (PubMed:24019528).  Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876).  Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity).  Plays a role in myoblast fusion (By similarity).  Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity).  Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis.  Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29.  Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension.  Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250).
What are the official names of this protein?
EH domain-containing protein 1, PAST homolog 1, hPAST1, Testilin.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
What are the subcellular locations of this protein?
Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Preferentially associates with tubular recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:19864458, PubMed:23596323). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity).
Protein: LKTA8_MANHA
Sequence: MGTRLTTLSNGLKNTLTATKSGLHKAGQSLTQAGSSLKTGAKKIILYIPQNYQYDTEQGNGLQDLVKAAEELGIEVQREERNNIATAQTSLGTIQTAIGLTERGIVLSAPQIDKLLQKTKAGQALGSAESIVQNANKAKTVLSGIQSILGSVLAGMDLDEALQNNSNQHALAKAGLELTNSLIENIANSVKTLDEFGEQISQFGSKLQNIKGLGTLGDKLKNIGGLDKAGLGLDVISGLLSGATAALVLADKNASTAKKVGAGFELANQVVGNITKAVSSYILAQRVAAGLSSTGPVAALIASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASVTAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKNNHGKNYFENGYDARYLANLQDNMKFLLNLNKELQAERVIAITQQQWDNNIGDLAGISRLGEKVLSGKAYVDAFEEGKHIKADKLVQLDSANGIIDVSNSGKAKTQHILFRTPLLTPGTEHRERVQTGKYEYITKLNINRVDSWKITDGAASSTFDLTNVVQRIGIELDNAGNVTKTKETKIIAKLGEGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKEIEQGSYTVNRFVETGKALHEVTSTHTALVGNREEKIEYRHSNNQHHAGYYTKDTLKAVEEIIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRKGDGNDIITDSDGNDKLSFSDSNLKDLTFEKVKHNLVITNSKKEKVTIQDWFREADFAKEVPNYKATKDEKIEEIIGQNGERITSKQVDDLIAKGNGKITQDELSKVVDNYELLKHSKNVTNSLDKLISSVSAFTSSNDSRNVLVAPTSMLDQSLSSLQFARAA
What is the function of this protein?
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture.  The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity).  This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis.  It has also weak hemolytic activity.
What are the official names of this protein?
Leukotoxin, Lkt.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein: RECO_PHOPR
Sequence: MEGLQRCFVLHYRPYSETSLILDVFSEDYGRLTILSKGARRKRSNLKGTLQPFTPLFMKWTGRGSMKTLTHAEPISISLPMRGYILYSAFYLNEVLVRVLENDTPYPVLFMDYLNALRELAQADNPEPALRRFELALLHHLGYGIDFLHCAGSGLPIDDLMTYHYREQKGFIASMMTGHFTFTGNQLLAIAARRFETPDQLKAAKRFTRIALKPYLGGKPLKSRELFIPRTRNIGK
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: HLDE_HELPY
Sequence: MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGEHFISALKARGIDASGILIDKTRCTTLKTRIIAQNQQIARVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQAMIALANQHHKLILCDPKGKDYSKYSHASLITPNRTELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKGELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILSLEKLLETLDQQKIIFTNGCFDLLHKGHASYLQKAKALGDILIVGLNSDASIKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVFEEDTPIKLIQALKPDILVKGADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTCND
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: FNBA_STAA3
Sequence: MKNNLRYGIRKHKLGAASVFLGTMIVVGMGQDKEAAASEQKTTTVEENGNSATDNKTSETQTTATNVNHIEETQSYNATVTEQPSNATQVTTEEAPKAVQAPQTAQPANIETVKEEVVKEEAKPQVKETTQSQDNSGDQRQVDLTPKKATQNQVAETQVEVAQPRTASESKPRVTRSADVAEAKEASNAKVETGTDVTSKVTVEIGSIEGHNNTNKVEPHAGQRAVLKYKLKFENGLHQGDYFDFTLSNNVNTHGVSTARKVPEIKNGSVVMATGEVLEGGKIRYTFTNDIEDKVDVTAELEINLFIDPKTVQTNGNQTITSTLNEEQTSKELDVKYKDGIGNYYANLNGSIETFNKANNRFSHVAFIKPNNGKTTSVTVTGTLMKGSNQNGNQPKVRIFEYLGNNEDIAKSVYANTTDTSKFKEVTSNMSGNLNLQNNGSYSLNIENLDKTYVVHYDGEYLNGTDEVDFRTQMVGHPEQLYKYYYDRGYTLTWDNGLVLYSNKANGNGKNGPIIQNNKFEYKEDTIKETLTGQYDKNLVTTVEEEYDSSTLDIDYHTAIDGGGGYVDGYIETIEETDSSAIDIDYHTAVDSEAGHVGGYTESSEESNPIDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEESTKGIVTGAVSDHTTVEDTKEYTTESNLIELVDELPEEHGQAQGPVEEITENNHHISHSGLGTENGHGNYDVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFDSVPQIHGQNKGNQSFEEDTEKDKPKYEHGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKDKPSYQFGGHNSVDFEEDTLPKVSGQNEGQQTIEEDTTPPIVPPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPAEPGKPVPPAKEEPKKPSKPVEQGKVVTPVIEINEKVKAVAPTKKPQSKKSELPETGGEESTNKGMLFGGLFSILGLALLRRNKKNHKA
What is the function of this protein?
Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides and tropoelastin.  This confers to S. aureus the ability to invade endothelial cells.  Promotes adherence to and aggregation of activated platelets (By similarity).
What are the official names of this protein?
Fibronectin-binding protein A.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A (By similarity).
Protein: MTFA_YERPS
Sequence: MIKWLWKANKPQAEMLAQWHEALNIPLLAPLNEPEQQRLVSVASQLLQQKRFIPLQGLILTPLMQARLALLFALPVMELGAKWLDGFHEVLIYPSPFIVAEDWQDDLGLVHSGQSVQSGQSWEQGPIVLNWQDIQDSFDLSGFNLVIHEAAHKLDMRNGGHSNGVPPIAMRDVAVWEHDLHHAMDNIQDEIDMVGVEGASMDAYAASNPAECFAVLSEYFFSAPELLEGRFPAVYQHFCRFYRQDPLARLKRWENSLADNPPPENTHSHR
What is the function of this protein?
Involved in the regulation of ptsG expression by binding and inactivating Mlc.
What are the official names of this protein?
Protein MtfA, Mlc titration factor A.
What is the protein family that this protein belongs to?
Belongs to the MtfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_NITSB
Sequence: MANHKSALKRVRQTKKRTERNRFYRTRMKNIIKDVKEAVASGNKAAAIEALKVANKRIHEYVSKGIIKKNNAARKVSKLHKLVNSMNEAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RS17_STAES
Sequence: MSERNDRKVYVGRVVSDKMDKTVTVLVETYKTHKLYGKRVKYSKKYKTHDENNSAKLGDIVKIQETRPLSATKRFRLVEIVEESVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.