PharMolix/UniProtQA huggingface dataset:
Protein: HEM1_NEIMB
Sequence: MQLTAVGLNHQTAPLSIREKLAFAAAALPKAVRNLARSNAATEAVILSTCNRTELYCVGDSEEIIRWLADYHSLPIEEIRPYLYALDMQETVRHAFRVACGLDSMVLGEPQILGQIKDAVRVAQEQESMGKKLNALFQKTFSVAKEVRTDTAVGENSVSMASASVKLAEQIFPDIGDLNVLFIGAGEMIELVATYFAAKSPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHDYDVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDMVNIVQSGKEARQKAAAAAETLVSEKVAEFVRQQQGRQSVPLIKALRDEGEKARKQVLENAMKQLAKGATAEEVLERLSVQLTNKLLHSPTQTLNKAGEEDKDLVHAVAQIYHLDK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: DXS_LAWIP
Sequence: MTHPPDTIVKSILSHISNPCDIQKLSLQDKLTLAEELRSIIIKTVSNNGGHLAPSLGVIELTLALLATFNPAEDKLLWDVGHQTYAWKLLTGRAHNFSTLRKLNGLSGFPKITESQYDHFGAGHAATSISAALGMAMARDLQGLKHHVIAIIGDGSLTAGMAFEGLNQAGAMGRRLIVVLNDNEMSISKNVGALSLFLSRNMERGWVRRVRHEIKDWLKSIPSIGDEVAEYASRTHRSLKTVFTPGILFEAFRFNYIGPVNGHDIESIEKHLAMAASIDDQPVLLHVLTKKGKGYEPAEKNPASYHGLGAFDIQTGIPKSNSQNSPPTYTEVFGKTLCELAEKDKRIVTITAAMASGTGTSLFKAKFPTHFTDVGICEQHAVTFAAGLASQGYKPFVAIYSTFAQRAYDQIIHDVCIQKLPVTFCLDRAGIVGEDGATHHGAFDISFLRCIPNISILAPRDEAELQSAIYTALSFNSPLAIRYPKGNGVGVTLPNESTPLPFEGELLKEGHDAIIIAIGSMVMPAYSAAQQLQEEKNLSIAVFDSRWISPLPQHQLIELANTFNNILLIEENALAGGFSSAVVELFADNQCLHGQRIQRIGIPNYFIDHGSQKELKQCLLLTVDGIKKMLLQMLQPE
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: CYB_LEMCA
Sequence: MTNIRKNHPLMKIMNSSFIDLPTPSNISSWWNFGSLLGACLALQIITGLFLAMHYTADTTTAFSSVTHICRDVNYGWVIRYLHANGASMFFLCLFIHIGRGLYYGSFTLSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIATLVMVHLLFLHETGSNNPLGTSSDSDKIPFHPYYTIKDLLGLMLLILLTMTLVLFSPDLLGDPDNYSPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILAIIPMLHTAKQRSMVFRPLSQYLFWILTADLFILTWIGGQPVEHPFITIGQMASILYFSLILIMMPVVSLIENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: IRC6_YEAST
Sequence: MVLQYPQNKILVLSDHPHNFLKTQFLQDLFHCSSTGISIVKDQTWENRYYKVHFDLYIDSCKEIPVWVEEFITPECEPLRNVMAGIILITDIRQTKPQELLHQFMIAAHRNTFVVLANVNEEVEQDEIDELNEIWSNAFTNVIEFVNWKRSKPTVNHNDYGEKLGLDRIQEIIDTHDWLNCEVQPATKIREEIPNEMPLEQIIRNLQSARLKYKSIENSSEADAFANEMADELSRYL
What is the function of this protein?
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
What are the official names of this protein?
Increased recombination centers protein 6.
What is the protein family that this protein belongs to?
Belongs to the IRC6 family.
Protein: BMAE_ECOLX
Sequence: MNLKKIAIASSVFAGITMALTCHAVTVTATHTVESDAEFTIDWVDAGPTTTDAKDGEVWGHLDMTQTRGTPTFGKLRNPQGETSPGPLKAPFSFTGPDGHTARAYLDSYGAPIHNYAGDNLANGVKVGSGSGNTPFVVGTASRLTARIFGDQTLVPGVYRTTFELTTWTD
What is the function of this protein?
This protein is a non-fimbrial hemagglutinin that is specific for blood group M.
What are the official names of this protein?
M-agglutinin.
Protein: MFAP1_DROME
Sequence: MSAATAAAAASGIQSTAGAIPMRNEKGELSMQKVKVQRYISGKRPDYARADSSSEESDDDDFIDTRKRLERHKAERHKLELSRQGGSAEGEERAAGEGQEEDDAEVDDPRLRRLRQRPVDMEDMERERRERHRHIHEPEIMESDSEDEEEDEGAQGAIQRGTNKITLASESDTDAELSDTELENRRTKLRSRMLQQQREEEVLQKEDEKQSESSESESSEYEEETESEEDNEPRLKPLFVRKRDRATIQEKEREAQKQKQLEAEAKRAAKERRRATLRMVEESVKKDLEKTKPETNEACIEDVCTDDENDEVEYEAWKLRELKRMKRDREERDNVEREKLDIDRMRNMTEEERRQELRQNPKVVTNKATKGKYKFLQKYYHRGAFYLDEENDVLKRDFAQATLEDHFDKTILPKVMQVKNFGRCGRTKYTHLVDQDTTKFDSPWYAESSSNIKFHNEHAGGMRQQFDKPTGSKRKKME
What is the function of this protein?
Required for pre-mRNA splicing.
What are the official names of this protein?
Microfibrillar-associated protein 1, Spliceosome B complex protein MFAP1.
What is the protein family that this protein belongs to?
Belongs to the MFAP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL30_BACP2
Sequence: MANKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIRGMINKVSHLVSVKEQ
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: ECHR_DICCH
Sequence: MSISFSNFDFINSTIQNYLNRKLKSYGDLKYAYLIMNKKKPTDVVIISNYPSEWVEIYRSNNYQHIDPVILTAINKISPFSWDDDLVISSKLKFSRIFNLSKEYDIVNGYTFVLHDPGNNLATLSFMFEENRSGELEEIVQNNKEKLQMLLISAHEKLTSLYREMSKNKNNSKSQEPNIFSQRENEILYWASMGKTYQEIALILGITTSTVKFHIGNVVKKLGVLNAKHAIRLGVEMNLIKPVEPVKARS
What is the function of this protein?
Functions as a potential ohlL-responsive transcriptional regulator.
What are the official names of this protein?
Transcriptional activator protein EchR.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-regulated transcriptional regulatory protein family.
Protein: DCUP_SHELP
Sequence: MAELKNDRYLRALLKQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCRNAELACEVTLQPLRRYDLDAAILFSDILTVPDAMGLGLYFETGEGPRFERPTDTLDAIKKLAVPDPEDELGYVMKAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKTFEKIKKMAYAEPAALHMLLDKLADAVTLYLNAQVANGAQSLMIFDSWGGALSHTAYREFSLRYMQKIVDGLTRHADGRQVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYASPERIHEEVRQILAGYGEGSGHVFNLGHGIHQHVDPEHAGAFIKSVHELSAQYHK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_LEUMM
Sequence: MNFIEDLKWRGALNQVTDEAGLIEAMASGEIGAYVGTDPTADSLHLGHLIPFMVLKRFQNAGGKAVIIIGGATGAIGDPRPTTERQLLSPEQLRQNEKGITEQVTKLFGDEKTAIVNNNDWLGKLTLTDFLRDYGKLFSINVMLKKDVVASRLETGISFTEFTYQILQGIDYHELWRRHNVQLQIGGSDQWGNITSGIDLIHSIEGNNATAFGLTIPLMTDSSGKKFGKSEGNAIWLNPEKTSPYTFYQFWYNQSDEDVVKYLKYFTFLGVDEINNLEQEAKNNPGGRIAQKRLAQEVTKFVHGEQAVADAEKLSAALFSGDVANLSAADIADAFGGVPSFDITSEKKNVVDFLVDGEVEKSKRQAREDVTNGAITISGEKVTDVNFEIDPTKHYDGEFVLVRRGKKKYFLGKVK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_ECO45
Sequence: MSGTLLAFDFGTKSIGVAVGQRITGTARPLPAIKAQDGTPDWNIIERLLKEWQPDEIIVGLPLNMDGTEQPLTARARKFANRIHGRFGVEVKLHDERLSTVEARSGLFEQGGYRALNKGKVDSASAVIILESYFEQGY
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1187_THEMA
Sequence: MKNLKNKHFALLYLVLFLVLAKLSPFIITALIMGLYLSIIIDYVARFLEVFIKKPRVLPRVISNVLVFLTIAYSAVNFFPVIVREAQKVFSEIDRIRSGLENIDIPGWLSSILSSISASFSEGALSLVNKIVGYVPSFITAAILIVITAFIVSSLKRLIKENVHYLFPTNPSDGKEFLKTTYTEFERFVGGQVLVAIFVGLFVGFGAFIFKIPSAFFLGMLAFVTDFVPYLGVVISAIPLLMLAFSVHGLSGLLIGTIILVAANQLEMWVLAPKIQSNTLNVHWFIILIMILILGDLFSFGGVLIALPFLIFLKNFWKQYVMGG
What are the official names of this protein?
Putative transport protein TM_1187.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RCNB_ECOL6
Sequence: MTIKNKMLLGALLLVTSAAWAAPATAGSTNTSGISKYELSSFIADFKHFKPGDTVPEMYRTDEYNIKQWQLRNLPAPDAGTHWTYMGGAYVLISDTDGKIIKAYDGEIFYHR
What is the function of this protein?
Influences nickel and cobalt homeostasis.  May act by modulating RcnA-mediated export of these ions to avoid excess efflux (By similarity).
What are the official names of this protein?
Nickel/cobalt homeostasis protein RcnB.
What is the protein family that this protein belongs to?
Belongs to the RcnB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: NUCS_THEKO
Sequence: MSKDKVTVITSPSTEELVSLVNSALLEEAMLTIFARCKVHYDGRAKSELGSGDRVIIVKPDGSFLIHQSKKREPVNWQPPGSRVRLELRENPVLVSIRRKPRETLEVELEEVYMVSVFRAEDYEELALTGSEAEMAELIFENPEVIEPGFKPLFREKAIGTGIVDVLGRDSDGNIVVLELKRRRAELHAVRQLKSYVEILREEYGDKVRGILVAPSLTSGAKRLLEKEGLEFRKLEPPKRDSKKKGRQKTLF
What is the function of this protein?
Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
What are the official names of this protein?
Endonuclease NucS.
What is the protein family that this protein belongs to?
Belongs to the NucS endonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IM30_ORYSJ
Sequence: MEIRAPPTSLRLAPPPPASASFRRTALRTSFLNGSVSLRLIQVRQSNVNRFKCNGIRSNLLDRFSRVVKSYANAVLSSFEDPEKILDQAVLEMNDDLTKMRQATAQVLASQKRLENKYKAAEQASDDWYRRAQLALQKGDEDLAREALKRRKSYADNASSLKAQLDQQKGVVENLVSNTRVLESKIAEAKQKKDTLKARAQSAKTSTKVSEMLGNVNTSGALSAFEKMEEKVMAMESQAEALGQLATDDLEGKFALLETSSVDDDLAQMKKEISGSSSKGELPPGRTAVSNSGAARPFRDIEIENELNELRKKANEY
What are the official names of this protein?
Probable membrane-associated 30 kDa protein, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the PspA/IM30 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Peripheral membrane protein. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RL6_CAUVN
Sequence: MSRIGKKAVAIPSGVQVTLAGQTVTVKGPKGQLSWTIADEVEVKQEGAELLLAPRVDTKRAKGMWGLSRTLVANMVHGVTVGFEESLELVGVGYRAAMKGTALSLQLGFSHDVDVAAPAGVTFAVPKQTEIKIAGIDKQAVGEIAAKIRRIRPPEPYKGKGVRYAGEKVRRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: VP7_ROTBN
Sequence: MYGIEYTTILIFLTSITLLNYILKSITRMMDYIIYRFLLIVVILATIINAQNYGVNLPITGSMDTAYADSTQSEPFLTSTLCLYYPVEASNEIADTEWKDTLSQLFLTKGWPTGSVYLKEYADIAAFSVEPQLYCDYNLVLMKYDSTQELDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISTGSSCTVKVCPLNTQTLGIGCLITNPDTFETVATMEKLVITDVVDGVNHKLNVTTATCTIRNCKKLGPRENVAVIQVGGANVLDITADPTTTPQTERMMRINWKKWWQVFYTVVDYVNQIIQTMSKRSRSLNSSAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: ENGB_ECO27
Sequence: MTNLNYQQTHFVMSAPDIRHLPSDTGIEVAFAGRSNAGKSSALNTLTNQKSLARTSKTPGRTQLINLFEVADGKRLVDLPGYGYAEVPEEMKRKWQRALGEYLEKRQSLQGLVVLMDIRHPLKDLDQQMIEWAVDSNIAVLVLLTKADKLASGARKAQLNMVREAVLAFNGDVQVETFSSLKKQGVDKLRQKLDTWFSEMQPVEETQDGE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: RS3_ALKOO
Sequence: MGQKVNPHGLRVGIIKDWDTKWYANKRDFGDLLVEDNEIRKFVKKKLFLSGVSRIEIERAANNKVKVNVHTAKPGMVIGKGGQGVEDLRKDIEKISKKNVAVNVIEVKRPETDAQLVAENVAFQLERRVSFRRAMKQVMQRAMKSGAKGIKVATSGRLGGAEMARTEGYSQGNVPLQTLRADINYGFAEADTTYGKLGIKVWIYKGEVLPTKGRVASNNEEVVGNVEKNTRGKKREAK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: FLHD_SALNS
Sequence: MHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMANTLGALTLPQMVKLAETNQLVCHFRFDDHQTITRLTQDSRVDDLQQIHTGIMLSTRLLNEVDDTARKKRA
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPM1_MOUSE
Sequence: MASTGASRSLAASPRPPQGRSSRQDKYSVLLPTYNERENLPLIVWLLVKSFSESAINYEIIIIDDGSPDGTREVAEQLAEIYGPDRILLRPREKKLGLGTAYIHGIKHATGNYVIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFITQILLRPGASDLTGSFRLYRKEVLQKLIEKCVSKGYVFQMEMIVRARQMNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT
What is the function of this protein?
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.
What are the official names of this protein?
Dolichol-phosphate mannosyltransferase subunit 1, Dolichol-phosphate mannose synthase subunit 1, DPM synthase subunit 1, Dolichyl-phosphate beta-D-mannosyltransferase subunit 1, Mannose-P-dolichol synthase subunit 1, MPD synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: CCS1_GUITH
Sequence: MNYIIKFLNKLNNLTVAIIILLAIALASALGTVIEQNKNTDFYLKNYPLTKPLFNFVTSDLILKFGLDHVYTSWWFIFLIILLLLSLTLCTITRQLPALKLARLWQFYTNFNTKAKFQIRFKTNSSSLTKLTYYLEEKNYKIKHFNHFVYAYKGIFGRVSPIIVHFSLVIVLIGSMLSTTQGRTQEAFIVVNQEKPVLDTYEAYVNDFKIAYNSQGLIDQFYSDLILETRQASKIQKTIYVNEPLNYSNITIYQTDWNIDNLVICIDNQNYYSIPLQFIELPNGSESKYWINRLDLFGQSVFCVVNDLTGIVYLYNQNKDLICISSLGEFITLNGHTITFNKLVASTGLQFKLDSFIPLVYLGFLLLMISTLLSYISYSQVWLVKNGSTTYIFGSTNRAKFAFIKQLTEIANQC
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein Ccs1.
What is the protein family that this protein belongs to?
Belongs to the Ccs1/CcsB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ISU1_TRAHO
Sequence: MLTPFNNFFQQRQNYHSSVIDHFENPRNVGSYDKSANDVGTGLVGAPACGDVMKLQIKVENDIIKDAKFRTFGCGSAIASSSLATEWIKGKSISDSLKITNKDIAKKLSLPPVKLHCSMLAEDAIKAAISDYQKKNGL
What is the function of this protein?
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitosomes, which is required for maturation of both [2Fe-2S] and [4Fe-4S] proteins (PubMed:18311129).  First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISU1.  In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins.  Cluster assembly on ISU1 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).
What are the official names of this protein?
Iron sulfur cluster assembly protein 1, Iron sulfur cluster scaffold protein 1.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Cytoplasm. Note=It is unknown how the different localizations of several ISC components to mitosomes and cytoplasm can be reconciled with the usually tightly coordinated function of these components.
Protein: RPOZ_RHOE4
Sequence: MSSTSAASAAGQGALPAYDTPLGITNPPIDELLERTSSKYALVIYSAKRARQINDYYNQLGDGILEYVGPLVEPGLQEKPLSIALREIHADLLEHTEGE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: YP199_YEAST
Sequence: MKGTGGVVVGTQNPVRDYNHSTDEEYQRLRRLADEAYKKRDQLSHESQTAYQQGDKKLAHELSEKSKAQLKTAEDFNMQAAEYVFVENNADSSSNEIDLHGLYVKEALFILQKRIKFAIDHNEPQLNVIVGKGLHSQNGIAKLKPSIEEFCAKHGIRNHLEKGNSGVLVLELQGVQMQMDGPAVNAPTNQYNAQPHPQYNNNGGQPQGQAQNYNNSGNDNKDSTLTSIFKIFCNCIQSLA
What are the official names of this protein?
Smr domain-containing protein YPL199C.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMCE_ORYSJ
Sequence: MQPASPVSGDAGPVAEAVPPRGAPQVLVRRRSVPFSPDSPLAPGSRGGGERRSTFREDVSHAAAETYLVTRLAFILLRYLGVGYRWISQLAALIIYAILLMPGFIRVGYYYFFSRQVLRSVIYGDQPRNRLDLYIPRDPKKPSPVVAFVTGGAWIIGYKAWGALLGRRLAERGIIVACIDYRNFPQGTISDMVSDASDGISFVCETVGAYGGDPNQIYLMGQSAGAHIAACALLEQAAKESRGEQISWSVTQIKAYFGLSGGYNIENLVDHFHERGLYRSIFLSIMEGKKSLPHFSPETVAKKLCPETIALLPQIVLLHGTDDYSIPFSASETFAGVLKQAGAKAKLLLYEGKTHTDVFLQDPLRGGRDKLVEDVISVIHADDADAREKDALAPIPGRLVSEWQIKLAHRISPF
What is the function of this protein?
Catalyzes the demethylation of isoprenylcysteine methylesters.
What are the official names of this protein?
Probable isoprenylcysteine alpha-carbonyl methylesterase ICME.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Isoprenylcysteine methylesterase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: PAX6_MOUSE
Sequence: MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
What is the function of this protein?
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas.  Required for the differentiation of pancreatic islet alpha cells (PubMed:9163426).  Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters.  Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).  Acts as a transcriptional repressor of NFATC1-mediated gene expression (PubMed:23990468).
What are the official names of this protein?
Paired box protein Pax-6, Oculorhombin.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. SUBCELLULAR LOCATION: [Isoform 5a]: Nucleus.
Protein: RIMO_BORPE
Sequence: MSSPKVGFVSLGCPKALVDSERILTQLRTEGYEVTPEYNDADVVVVNTCGFIDSAKAESLEAIGEAIAENGKVIVTGCMGVEESVIRQVHPSVLAVTGPQQYEEVVRAVHGVAPPRQDHNPYLDLVPPQGVKLTPRHYAYLKISEGCNHRCSFCIIPSMRGDLVSRPVGDVLSEAERLVRAGVKELLVISQDTSAYGVDIKYRSGFWNGRPVKTRMTELCAALSELGVWTRLHYVYPYPHVDEVIGLMADGKVLPYLDIPFQHASPRILRAMKRPAFEDKTLARIKRWREECPDLTLRSTFIVGFPGETEEDFQYLLDWMSEAQLDRVGCFQYSPVEGAPANTLDNPVPDEVKQERWERFMEHQQAISTARLSTRVGREIDVLIDSVDEEGAVGRSSADAPEIDGCVYVDSEQPLKAGDMVRVRVTDSDEYDLWGERIA
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_YERPB
Sequence: MAKNIQAIRGMNDYLPADTAIWQRIESILKQVLSGYGYSEIRMPIVEQTPLFKRAIGEVTDVVEKEMYTFDDRNGESLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRYERPQKGRYRQFHQLGAEVFGLPGPDIDAELILLTARWWRALGIFEHVKLELNSIGSLAARADYREALVAFLEQHVEVLDEDCKRRMYSNPLRVLDSKNPDVQQLLDDAPKLSDYLDEESKQHFAGLCELLDKASIPYTVNERLVRGLDYYNRTVFEWVTHSLGAQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNADFQVPATVDAYVISSGEGAQSAAMLLAESLRDALPTLKIMTNYGGGNVKKQFTRADKWGARVALMLGESEVAAQQVVVKDLRNGEQETLAQADVAARLALMLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.