PharMolix/UniProtQA huggingface dataset:
Protein: IL1B_BUBCA
Sequence: MATVPEPINEMMAYYSDENELLFEADGPKQMKSCIQHLDLGSMGDGNIQLQISHQLYNKSFRQVVSVIVAMEKLRNSAYAHVFHDDDLRSILSFIFEEEPVIFETSSDEFLCDAPVQSVKCKLQDREQKSLVLASPCVLKALHLLSQEMSREVVFCMSFVQGEERDNKIPVALGIKDKNLYLSCVKKGDTPTLQLEEVDPKVYPKRNMEKRFVFYKTEIKNTVEFESVLYPNWYISTSQIEERPVFLGHFRGGQDITDFRMETLSP
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: RS6_CHLT3
Sequence: MKKLYETTIVVDGGLDESVIAATVEKVTGLITSLGCEVKTVLDVGRKNLAYPIGKATIGYYVHIEFESDGTALKELERQYRLNESIIRFLTIILDKRLLEMRERVLKYGAPPQTSEDNSSEGEEFVEEKKSSE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: ATPL_STAES
Sequence: MNLIAAAIAIGLSALGAGIGNGLIVSRTVEGVARQPEARGQLMGIMFIGVGLVEALPIIGVVIAFMTFAG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DXR_PSYWF
Sequence: MTQRIAVLGATGSIGDSTLSILAAHPEHYQVYALSGHGRLDKLFELCQQFRPSRVAVPENKVDDFATRLAAAQIACEVVGGQAGLDDIALDPQVDTVVAAIVGAAGLASTLSAAKAGKRVLLANKEALVMAGSLMMQAVRDNGATLLPLDSEHNAIFQCLPPQIQQNNTAIHDASHGVKKLWLTASGGPFLNKTWEQMQAASVSEAVKHPNWSMGQKISVDSATMMNKGLELIEACHLFDLAESQINVVIHPQSIIHSLVEYCDGSFLAQMGSPDMRTPIAHALAYPNRISAGVESLDLYQLSSLEFIKPDLKKFACLKLAREAMQSGQAASITLNAANEVAVEAFIKQQVSLTDIALINAQVLDKMLGKDKSVAGHAAISVRQITELNDILMIDKIAREQAQLEVMACRN
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: DUT_STRGG
Sequence: MTRGPVDVLIRLLDPDVPIPSYGHPGDAGADLVTTEAAELAPGERAVLPTGVSIALPDGYAAFVHPRSGLAARCGVALVNAPGTVDAGYRGEIKVIVVNLDPRESVRFERFDRIAQLVVQQVEKVRFHEVAELPGSARAEGGFGSTGGHASVDGAEGGITHGGNSYASVVSDREGQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ANM1A_XENLA
Sequence: MAEATTCNMENFVAKLANGMSLRTPIEDVNSAPPEGGVKTNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGAKKVIGIECSSISDYAIKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIYARDKWLTPDGLIFPDRATLYITAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVSNACLIKEVDIYTVKVDDLSFTSPFCLQVKRNDYIHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMKPNAKNNRDLDFTFDIDFKGQLCELSCSTDYRMR
What is the function of this protein?
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins.  Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity).  Methylates cirbp to regulate its subcellular location (PubMed:12466543).  Acts transiently during metamorphosis as a transcription coactivator, enhancing thyroid hormone (T3) receptor (TR)-mediated transcription by enhancing TR binding to the T3 response element (TRE), and histone modification through recruitment of other coactivators (PubMed:19047371).
What are the official names of this protein?
Protein arginine N-methyltransferase 1-A, xPRMT1, Histone-arginine N-methyltransferase PRMT1-A.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Cytoplasm.
Protein: GLMM_WIGBR
Sequence: MENNKYFGTDGIRGKVGKNPITPEFFFKLGFVIGNLLYKENSFNKVLIGNDTRQSGFILESTLAYGLSCSGLSSLLIGSIPTPAISYLTSYLKADAGISVSASHNLCSDNGIKIFSVNGKKLSDKLENDIEIKLSKLTILKKNIYCKNKYQKVNLINQYIKFCRSTVSNNINLKGLNIVVDCANGSTYQIAPVLLKNLGANVFKLGCNPNGKNINYKCGTTNISLLRKKVLQNKAHLGIAYDGDGDRIIMIDHLGNIVNGDQILYIIACDKLKNKKLNGGVVGTLMSNMGLEIALKKLEVPFIRSRIGDRYVLNELEKQGWKIGAENSGHVILLDHTSTGDGIIAGLQILSIIAKNNTTLKNLCNGINLFPQILINVQIDKENNPLESNIVKKIIEISKKNLDGNGRILLRKSGTEPLIRIMVEGKEENKIIKLAYNIANAVKSVI
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RNFG_PSEAB
Sequence: MDAATRRSMLRNALLLGLFALVGVGLVALVQQFTEARIAEAQREARGRALLELLPPGSYDNHPLDSQVPTFAPKLLGLDAPRPAYVARLHGQASAVILQASAPDGYSGAIQLLVGVTAQGRLLGVRVVAHKETPGLGDRIELAKSPWVHGFDGKSLGDPADAGWAVKKDGGTFDQFAGATVTPRAVVRAVHKALRYFDANRERLLAPEEAAGHE
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit G, Rnf electron transport complex subunit G.
What is the protein family that this protein belongs to?
Belongs to the RnfG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MURA_TRIV2
Sequence: MPEADSSVLQIWGGHPLRGHVKISGAKNSALVIMAGALLCSGDCRIRNVPLLADVERMGEVISALGVRLTRQADIIDINASEIKTSKAPYELVTQLRASFFAIGAILARLGVAQMPLPGGCAIGARPVDLHVRGLQAMGAEVQIEHGICNAYVPGSGGRLKGAKIYLDTPSVGATETLMMAATLADGETILENAAREPEVVDLANFCKAMGANIQGAGTSTITIVGVPKLHSVDYSIIPDRIEAGTFLVAGAITRSEITLSSVVPDHLIPLIAKLRDIGVTIIEESPDCLRILPAEILKATDIDTLPHPGFPTDMQAPFMALLTLAEGDSIINESVFENRLRHASELNRLGADIRVKGNTAFVRGVPILSGAPVIGTDLRASAALVIAGLAAEGKTTIQGLHHLDRGYDQIDVKLQQLGAKILRVREEPANAEVAANNNASPAPIST
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBJL_ECOL6
Sequence: MNINVAELLNGNYILLLFVVLALGLCLGKLRLGSIQLGNSIGVLVVSLLLGQQHFSINTDALNLGFMLFIFCVGVEAGPNFFSIFFRDGKNYLMLALVMVGSALVIALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHSGMESRQLSLALDNLSLGYALTYLIGLVSLIVGARYLPKLQHQDLQTSAQQIARERGLDTDANRKVYLPVIRAYRVGPELVAWTDGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQMGDEIALVGYPDAHARLDPSFRNGKEVFDRDLLDMRIVTEEVVVKNHNAVGKRLAQLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKTIADRIGFISIHSQVTDLLAFCAFFVIGLMIGMITFQFSTFSFGMGNAAGLLFAGIMLGFMRANHPTFGYIPQGALSMVKEFGLMVFMAGVGLSAGSGINNGLGAIGGQMLIAGLIVSLVPVVICFLFGAYVLRMNRALLFGAMMGARTCAPAMEIISDTARSNIPALGYAGTYAIANVLLTLAGTIIVMVWPGLG
What are the official names of this protein?
Putative transport protein YbjL.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SPX1_OCEIH
Sequence: MVTLYTSPSCTSCRKARAWLEEHNIPFTERNIFSEPLSLDEIKEILRMTEDGTDEIISTRSKVFQKLDVNIDQLPMKNLFNLIQKNPGLLRRPIILDEKRLQVGYNEDEIRRFLPRTVRTFQLREAQRMVN
What is the function of this protein?
Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes.  Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP).  This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
What are the official names of this protein?
Global transcriptional regulator Spx 1.
What is the protein family that this protein belongs to?
Belongs to the ArsC family. Spx subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: V1AR_MOUSE
Sequence: MSFPRGSHDLPAGNSSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWGLSFVLSIPQYFIFSVIEFEVNNGTKAQDCWATFIPPWGTRAYVTWMTSGVFVVPVIILGTCYGFICYHIWRNVRGKTASRQSKGGKGSGEAAGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWTPFFIVQMWSVWDTNFVWTDSENPSTTITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCQSIAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGTWKDSPKSSKSIRFIPVST
What is the function of this protein?
Receptor for arginine vasopressin.  The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.  Involved in social memory formation.
What are the official names of this protein?
Vasopressin V1a receptor, V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SECA_MYXXD
Sequence: MIEWTLKKLIGTKNERELKKAHAKVARVNELETRMRALKDEDFVSETNRMRQEIQNGRSLDDLLFEAFAITREAARRVIGQRHYDVQLIGGMFLHEGCIAEMRTGEGKTLTATLPTYLNALSGRGVHVVTVNDYLARRDAEWMGRVYRFLGMTTGCVLHELNDKQRQEAYRSDITYGQNNEFGFDYLRDNMKFRLQDYVQRELNFAIVDEVDSILIDEARTPLIISGPTEDSTDKYYRVDQVIPGLVPDQDYTLDEKHRSVSLTDDGIEKLQKRLGVGNLYDPGEIEMLHHVDQALRAHTLYKRDKDYVVKDGEVVIVDEFTGRQMPGRRWSDGLHQAIEAKEGVKIENENQTLATVSFQNYFRMYSKLAGMTGTADTEAEEFAKIYNLDVRVIPTNRPPIRKDLQDVVYKTEREKFEAVAAEIEELHKNGQPVLVGTVSIAKSEVVASFLKKRGIPHNVLNAKQHQREADIVAQAGRKGAVTISTNMAGRGTDILLGGNAEVLAKASMGPPPEPPTSAPDGQPLDLTAYEAEVAAWEQKFADTKAKLEEQTKKEREEVHTAGGLFIIGTERHESRRVDNQLRGRAGRQGDPGGSRFFLSLEDDLMRIFGSERIQGLMERLGMEEGEVIEHVWLSRAIEGAQKRVEGHNFDIRKNLLEYDDVMNQQRRTIYKLRRQVLAAGAGVPLVEYDEDPKTRIKTRSERTVSWADFRELILDSMEDVIVSLTDTYAPTRGVEGWDIAALQQGVKETFNLEMNFEGVGNREELQEHIYKAAEKVFQARDEEFGENFMRFLQYNYLATIDRLWKDHLLAMDHLRQGIGLRGYGQKDPKQEYKKEGYQGFIQMLSAIKAQFVTQLMHVQPRSASSAAEEAARIQRQLAQQQKKAVEGRATADGKLDEGSVAAAARPAAASRPAVGRNDPCPCGSGRKYKKCHGASEASV
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: FLGI_ECOL5
Sequence: MIKFLSALILLLVITAAQAERIRDLTSVQGVRQNSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASLPPFGRQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAVIERELPSQFGVGNTLNLQLNDEDFSMAQQIADTINRVRGYGSATALDARTIQVRVPSGNSSQVRFLADIQNMQVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQANVSQPDTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSASLNNVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: MTOX_YERPA
Sequence: MDYDLIVIGSGSVGSAAGYYASQAGLNVLMIDSAMPPHQAGSHHGETRIMRHAYGEGEKYVPLVLRAQALWDQLAAQTGEKLFQACGVINLGPDNSTFLQNVQRSAQQYDLPVETLNSTQIREKWPVFTVPDNYIAVFEPQSGYLRSELAVKTLIKAVTEAGCGILFNCPVTAIESHQAGVDVVTIDGTYSATKVVVTAGTWVKELLPTLPVTPVRKVFSWHQADGRYSEANHFPAFTVEMPDNILYYGFPAQNDALKLGKHHGGQLIESAAQRKPFGRYAEDGTEVFSFLRHFLPGVGVCLRGEACSYDMSPDEDFIIDTLPEDERVMVVSGLSGHGFKFATALGEVAALFAQDKPSPIDISAFSLARFR
What is the function of this protein?
Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.
What are the official names of this protein?
N-methyl-L-tryptophan oxidase, MTOX.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family. MTOX subfamily.
Protein: FENR_LEVBA
Sequence: MTETYDITIIGGGPAGMFAAFYAGMHNAKTQLLESLSELGGQVNALYPEKTILDVAGLPAINGRDLIKAQREQLTQFPLTIKTGQEVTNVTANEVGFTVTTDAGTTQTTAIIVAIGNGAFAPRPLTVPGAEAATGKQLVYSVPRLADFQDQTVMVAGGGDAAIDQALMLEPVAKSVTLLHRRAQFRGLAHMVDLLHASTVAVKTPYLIREVAPTATGQLKVTLKEVGSQTATAEQIVDKLVVSYGYTSDHHTLAGWDIDLAETRNLINVSQTMETSVPGIYAIGDGVTYPGKQPLIATGYGEAPVAVQSIMTQFFPDRRGPMHSTSLTPQS
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: PFKA_ECO55
Sequence: MIKKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAIENMKRPFKGDWLDCAKKLY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase isozyme 1, ATP-PFK 1, Phosphofructokinase 1, 6-phosphofructokinase isozyme I, Phosphohexokinase 1.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_ECO81
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SYP_CORGL
Sequence: MITRLSTLFLRTLREDPADAEVPSHKLLVRAGYIRRVAPGIYSWLPLGLRAVRNIEAVVREEMDAIGGQELLFPALLPREPYETTQRWTEYGDSLFRLKDRKGADYLLGPTHEEMFAATVKDLYNSYKDFPVTLYQIQTKYRDEERPRAGVLRGREFVMKDSYSFDISDAGLDESYAKHRAAYQRIFDRLGLEYAICQATSGAMGGSASEEFLAVSENGEDTFVRSTSGNYAANVEAVVTQPGVERDIEGLPEAVTYETPVSETIDALVDWANSIDVQIEGREVTAADTLKCIVVKVREPGAEEAELTGILLPGDREVDMKRLEASLEPAEVELAVESDFADNPFLVKGYVGPVGLAKNGVKVLADPRVVTGTSWITGADEKERHVVGLVAGRDFTPDGFIEAAEIKEGDPAPAGEGTLTLARGIEIGHIFQLGRKYTEAFDVQILDENGKRAIPTMGSYGLGVTRLLAVLAEQRHDDAGLNWSVEVAPYQVHVVAANKDAAAIEAAERFAAELSAAGLDVLFDDRPKVSPGVKFKDAELLGMPFALILGRGYAEGKVELRVRGGEKSELDADQAVAQIVEMVAQARN
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_PERMH
Sequence: MAVCQICGKKTAHGNRVAHSATTTKRTWKPNLQKVKAVLPDGTTKKIYVCAKCLKAGKVRKAVR
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: COXX_COREF
Sequence: MSGTHQQHADQCKSDFLIATLWRNKPLETIKAYIALTKPRVIELLLVATIPAMLQAERGEHNIILILLTVIGGWMGAAAANTFNMVADSDIDQRMGRTRARPLVKHTVSNRDASIFAWVLTVASFLWLWLLCNSLTAAVFVMITIAFYIFVYTKWLKRRTHMNIVWGGAAGCMPVAVGWAVIVDQFPEGQPQQWWQAIVLFLIIFFWTPPHTWALAMKYREDYKAAGVPMLPVVRTPVQVTRQIVWYSVATVLVTFLLIPAAGWIYAAAAVLAGVAFLWMAIRLHLGIKNGAEVKPLKLFILSNNYLAVLFLALSVDAVLGIQTIGEMMGWNTTFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VF329_IIV3
Sequence: MISYSALTTHGKSTLPSIEGWNGNHNIVKNPPSAVHTRRIIKVGTDNCLLEATHESGGRSDQVIRQFARGVNPMVSVQYSNHGTGGNGSLTTPNDYSIFTTGGHGKLPNRIMKGGAFRPPIIKKEDLLPLSRLPREQTSVFSTKCSIDQTKKITPDVVEYFKHIHQNPIHSSASSQFTFSRDSPHHVPKNIHLMVNPNGGTVGSAQSTKVWNQKGSLGQPKITESTVATDVLTVSTNAPHSYHKQQTHPIPSNIDLLVQKDLLTTSANAPHSYHKQQTHSIPFNIDLMVNSDPIRTSADAPHSYRKQQTHPVPKNIHLMVNENHPPVLNVHTNARASKDDTGEARVWPRMESPLTVAGMDYLYPLKISQQKWHHGDNPIQLVNKVPHCEVNSGGGAAMGGRPRYSQMHQMEDQKMVLSKPRPERNHSKSQIENVGTVVKLNQERIFSGAKVLNRKIQVNSNH
What are the official names of this protein?
Uncharacterized protein 099R.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 329R family.
Protein: RLMF_SHESH
Sequence: MTKHSQKQNRQKQTTQKQTRRKKPAGKLKAKSEAKLDTRGKPETTEKKGLHERNLHRDGYDFEQLIEASPALKPYVRPNPYGNLSIDFADPLAVKALNLALLQLHYRIEYWDIPAGFLCPPIPGRVDYLHYIADLLAGIDSDTVGDKAEEQVEEIGTRQNVPYASKPESSAPKQRYKSQKRMKINALDIGTGANGIYPILGIQAYGWRFVASDVDPLSIENVNRIVGQNKALQGKLKTRLQTDHQKVFHGIIQADDRFDITLCNPPFHASLSEASEGSLRKVKNLAANRAAKGHKPEPAASKAKPDANELNFGGQKAELWCEGGEKQFLANMIRESKDFATQCLWFTSLVSKKENLQPCYAALEKVGAVTVKTIDMAQGNKLTRVLAWSYLTPKQQALWAKYRS
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VLS_DROME
Sequence: MFPQRSSELYRTPVTHQPPPALELAGNLEYPNLNIADLNARLENLSPRLHDCWDSIAINDHNHLALATNRREGRQWWGMLFGYGRDQMHHMSVDSANFKLQAEHTVNIVRYAEDDFLLVALGDTRLQAWSTYSKVRDSQSPYCLFLVGESSAHPTPISQLSVFKADPRTAVSGSADSTLNVWDLSGADMVSTYRSRSSHTDKLTGLATPAASVDKFVTCDRGGCARLWDVRAAAPSSTCLYADASHVLSFTSAAWAAASELQGDNHIYLGDYDGKVHTLDIRVPRKLAETREYFDKGHVAQLLINGPHLAAMSNLPASVKVANVQAGHEFIYTHQDTHSRLTDAVWTDDSTLITIGHGRKMVTHAIK
What is the function of this protein?
Involved in specific localization of cytoplasmic proteins during the formation of pole plasm.  Required for synthesis and/or stability of oskar protein (osk) and localization of tudor (tud) in both the nuage and posterior pole of the oocyte.  Required for normal posterior localization of osk in later stages of oogenesis and for posterior localization of the vasa (vas) protein during the entire process of pole plasm assembly.  May act by regulating the complex that contains the arginine N-methyltransferase csul.
What are the official names of this protein?
Protein valois, MEP50 homolog.
Protein: RL36_CORK4
Sequence: MKVRKSLRSLKNKPGAQVVRRHGKVFVINKKDPRFKARQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: MRAY_PSYCK
Sequence: MLVWLFSWLGHYYAPFYAVSSLTLRALLAVVTALAFSMVFGNRVIRRLRALKYGQAIRNDGPQSHLVKTGTPTMGGVLILSAIGVSTLLWARLNNPYVWILLIVMIIFGAVGWADDWLKIKYKNPKGLIARKKYFWLSMGALFVGISLYYIATLQPDIATTREMQDLLIPIFKDWMIPFSAVPFGIGFIIFTYFVINGASNAVNLTDGLDGLAILPVVLVAAGLGAMAYVSGDVRFADYLHVPYIAYNSEVIIVCGAMIGAGLGFLWFNAHPAQVFMGDVGALSLGAMLGTIAVMTRQEIAFAIMGGLFVAEALSVMLQVGSYKLRKKRVFRMAPLHHHFEEIGWKETQVVARFWIIAIILVILGLMTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS9_LISMH
Sequence: MAQVQYYGTGRRKSSVARVRLVPGDGKIVINNRDWEDYIPFAALREVIKQPLVATETLGNYDVLVNVHGGGYTGQAGAIRHGVARALLQVAPEYRPALKSAGLLTRDPRMKERKKYGLKGARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.