PharMolix/UniProtQA huggingface dataset:
Protein: RL16_BORGP
Sequence: MLSPKKVKYRKKQRGRLSGEAQKGNKISFGEYGLVSLETSFITARQIEAARIAMTRKIKRGGRVWIRIFPDIPYTKKPAETRMGKGKGGVDHWNAPVKLGTVMFEMAGVIEELAQEAMSLASSKLPVKTMFVVRRDLR
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: H2A2_ASHGO
Sequence: MSGKGGKAGSAAKASQSRSAKAGLTFPVGRVHRLLRKGNYAQRIGSGAPVYLTAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDDELNKLLGNVTIAQGGVLPNIHANLLPKKSAKATKASQEL
What is the function of this protein?
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.2.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: COAD_TROWT
Sequence: MSNRIAVVPGTFDPVTRGHMDILTRTSRIFNTLYVLVANNPDKTPLLPMHDRVDLVGQALEEYGFPRSEPKCDSESDRNGPIVKIHRFEKGLLVDCCKQLGATVIVRGLISADAHREASMAYANRNMSGIETVFILPDPPLSVVSSSMVRQLIALGGDISPYVPACVTRFFGTHSG
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PESC_CRYNB
Sequence: MAKIKKRGESGAAKNYVTRNQALKKLQISLSDFRRLCILKGIYPREPLNKKRANKGSSAPASFYYHKDIQYLLHEPLLVKFREHKAFAKKLARAIGRQEWGLAKNLEDAKPVARLDHLVRERYPTFTLALQDLQDPLNLVHLFSTLPTNPIPGKTLVPSEVIAECSRLISEWKLWAIRTHSLRKMFLGIKGVYYECEVPGQGGEPVRVRWLEGFEFQQHVPHDVDFRILLTFLDLYRTMVGFVLFKLYTDENLVYPPPLDVELDEQGESVGAFKLVERKAAEGADGKTQVSKKAVRKAIKGIKAAGDDADVDMDEGAKETDEEEDEDFVERPSKAQEVDDVASAPLTTYNSLLATSSTPARQNLLFSPYTFYLSRETSSRTWEFVVRAMGGKVITSLTAPTPADAPNADSITHVIIDRPITVERMREMEAGRKWVWIQPQWVADCVNKQKIISSEGYGPGQLLPPHLSPWDGEGELYRPWLEEQGEKAAEGQEGEEEEEAAEQDEGESEDEEEDGKEEVAAEYPPALLAAAQNPSDASLLHAAELEAETNGVSHSAFRAQLKEATKVHAKKVPASQKEKKGEEDLRKIMMSNKKAKLYEKMQYSNREKAAEKEKLEKKRKAIEKRKAKEAKA
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Pescadillo homolog, Nucleolar protein 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the pescadillo family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: VRTN_DANRE
Sequence: MIQRAEAVLSVLGELQEATECVGLDALTKVAVEVEQVLAPFPLPTAPCSEISSWQGIDAVAHRLYPGDAPTGLLPLVCKGEGNLLFDAASMLLVGSTSLSLELQVRAVVEMLIWKRYYLCGMIDSKVMLQAARFSLCAEESQDMLNLPIQVLEAIFDADVKASCFHGSFANMWHVYALASVLQCNIYSVYPMYNLKIRPYFNRLIRPRIWSKDTEPLTLHIMWSGDLEAGSVFKPHKFVALIHASDLKIGSPNSEQRMPLVKSLELQNQDTQLSYSNLKNKFNITKSTFYRWKRQSIEYHKKSVARYEAKHFFLTSYKQGKLIPLSQFKELFPEIPRSTYYAWKQELVSCCSLSGGSTGELSPGDSTEQDYWSSPEVKKTPGQGSFANMLAFKYEKLEGERNQNVTLMQEAKKSLQDCIVANTSFPYRIFKRKFPGISRSTYYNWRREAMLFIPFKEHSGSSEEGSDADKSQSPRSQMSPSKFDRQKLSPRVRISRRKHRSLRLAYHHRKMLREEAKMHIRRSKMSFIKFKLKFPTVSSSFYWLWRVSLNRKPEKPAVMSNSEESKSLAISPDVFQKIKTQGMFSFDGNIDCLNGQTEFTMPEYSPPDQSTNDHMFVMDVVALANFKAKAKLFLQQRFEEKAFPTFKEFRSYFPLTPRSTYYMWKRALHHGVPLIHA
What are the official names of this protein?
Vertnin.
What is the protein family that this protein belongs to?
Belongs to the vertnin family.
Protein: RL20_SHEB5
Sequence: MPRVKRGVTARARHKKVLKLAKGYYGARSRTYRVAVQAVTKAGQYAYRDRRQKKRQFRQLWIARINAAARQNGLSYSRFINGLKKASIEIDRKILADIAVFDKVVFATLVEKAKEALN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: METE_THEAC
Sequence: MTALITQEIGSFRKPDYLAKEFHKIERTPKFTELAERATRETLEVFERSGLDNIGIGGEMFRWEMYEHPAERIKGIIFYGMVRSFDNRYYRKGSAIDRLERREPFHVDEVKFVAGTTKKPLKVPITGPYTMMEWSFNDYYDSREDLAMEFARIINEELKDIASVWKQVSGGRRLEIQIDEPATTTHPDEMDIVVDSINRSVQGVDGEISMHVCYSSDYRLLYDRIPDLKIDGYNLEYSNRDTLERGLTDDKRVGFQDLKYFAQINESLQRKKFIGIGVTDVHIDYVEPVELIEDRINYALKIIGDPDLVRINPDCGLRTRSREIGEQKLRNMVMARNNILKQL
What is the function of this protein?
Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation.  The physiological methyl donor is unknown.
What are the official names of this protein?
Methionine synthase, Homocysteine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the archaeal MetE family.
Protein: OMTA_ASPFN
Sequence: MTLPNKAALVGLAHTLSEQVKRYLVTADETKSPEDHKLCIEGERTPSSTEHAQAWEIVRTCDRIGSLVHGPVPWLLSNALSHLDSACLAAATQLNLQDIIVDGPSPTSLDTIVTATGVSEDLLRRILRGCAQRFIFEEVAPDQYAHTDASKMLRVTGIHALVGFSCDEVMRSAAYFSNFLQQTKGKPPSWNVPSPFSLAFDPTKGLFDYYSTVDEVRGRRFDLGMGGTEATKPLVEEMFDFSSLPEGSTVVDVGGGRGHLSRRVSQKHPHLRFIVQDLPAVIHGVEDTDKVTMMEHDIRRRNPVRGADVYLLRSILHDYPDAACVEILSNIVTAMDPSKSRILLDEMIMPDLLAQDSQRFMNQIDMTVVLTLNGKERSTKEWNSLITMVDNRLETEKIWWRKGEEGSHWGVQQLRLRK
What is the function of this protein?
Involved in the conversion of sterigmatocystin to O-methylsterigmatocystin (OMST) and dihydrosterigmatocystin to dihydro-o-methylsterigmatocystin in the aflatoxin biosynthesis pathway.
What are the official names of this protein?
Sterigmatocystin 8-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: PABA_BACSU
Sequence: MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSPDFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHGKTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDLPIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA
What is the function of this protein?
Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate.  In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC.  PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB.  Also involved in the biosynthesis of anthranilate (By similarity).  Complements a glutamine amidotransferase-negative mutant (PubMed:2123867).
What are the official names of this protein?
Aminodeoxychorismate/anthranilate synthase component 2, ADC synthase, ADCS, 4-amino-4-deoxychorismate synthase component 2, Aminodeoxychorismate synthase, glutamine amidotransferase component.
Protein: ATPG_CUPTR
Sequence: MAGTKEIRTKIKSVQNTRKITKAMEMVAASKMRKAQERMRNARPYAEKVRNIAAHLATANPEFKHPFMQEREVKRVGMIVVTTDKGLCGGLNTNVLRSVTNELKSLQGRGVDVQATAIGTKGMQFLGRIGAKVVSHVVHLGDTPHLEKLIGAIKVQLDAFTNGEVDAVYLAYTKFINTMKQEPMVEQLLPLAADKLSQTEEEKRAYSWDYIYEPDAQTVVEELLVRYVEALVYQAVAENMASEQSARMVAMKAASDNAKNVIGELQLVYNKTRQAAITKELSEIVSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LGT_RALPJ
Sequence: MLIHPQFDPVALHLGPLAIRWYGLMYLAAFIMFLWFGRLRTRQPHIAAEGWTGRDLDDMLFYGVLGVILGGRLGYVLFYKPDWYFAHPLDIFKVWEGGMAFHGGFLGVVVAMMLYARMRGRSWMQVTDFIAPMVPCGLAAGRLGNFINGELWGRVSSPNLPWSMMFPQAQGEDREWLLSHAQEAVTSGLQAVFDQYHMLPRHPSQIYQFLGEGVLFFILLWLYARKPRPMGAVSGAFLLGYGVFRFAAEFAREPDNFLGLLAANLSMGQWLSLPMILIGIAMLVWSYRRAGNGEKNQAHA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YGI2_YEAST
Sequence: MDVTFLTKNVQINGTQFKILLQNGQGECALIALANVLLISPAHARYAQEISRLVRGKETVTLNELVQTLADMGVQNPNGTDVDKQQLLQILPQLYSGLNINPEFNGSFEDGVEMSIFRLYNVGIVHGWIIDGDNDPNSYEHVSKYSYMGAQKVLVQSYEIQKNNAQFENSEQIQSDAPYLKSFLARSATQLTEYGLTHLREILVERSYAVLFRNDHFCTLYKNNGELFTLVTDPTYRNRKDINWQSLKSVNGSQDSYYTGNFIPTSLERTETTATGQNESYISNPFSDQNTGHVTSNQVNSGASGVQQIEDDEELARRLQEQEDMRAANNMQNGYANNGRNHQRERFERPEKNSKKNKFLPFNGSNKEKKRDKLKKNCVIM
What are the official names of this protein?
Uncharacterized protein YGL082W.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RSGI_BACSU
Sequence: MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSETRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEMALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILISTVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIKSNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQKEEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYHRDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE
What is the function of this protein?
Anti-sigma factor for SigI.  Negatively regulates SigI activity through direct interaction.
What are the official names of this protein?
Anti-sigma-I factor RsgI, Regulation of sigma I protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MCSB_CLOP1
Sequence: MVQWISPLDNSIVIASKVKILRNIKGIKFTKLLNEEEFNDLLSMVLGRLKEIDILDKCYVVKLKDGEEKIIDYYKENFGLIKYFENKDNLIFIMNKNGEFNILLNEEEHIGIECTNSGLSLREVYSKVDNLDDLIEEKIHYSFDSELGYLTSNIKNLGTALRAKVFIHLPLLSSNNLIRIIKNALKEEGITLKSIYNSGNKDVGNIYEVSNIKTLGMSEKDILDSLISITNKLILREKNQRDNLSKDEYIELKDDILRSLGVLRNTYSIDRDEALKYLSYVRLGVELGIIEDLSLKSVNSAMIEIQPDMINNSSIKKRDIQSLKIERAKIIRNALNT
What is the function of this protein?
Catalyzes the specific phosphorylation of arginine residues in proteins.
What are the official names of this protein?
Protein-arginine kinase.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: DNLJ_STRTD
Sequence: MEKRMKELVDKLNQYAKEYYTEDNPSVSDAEYDKLYRELVTLEAEHPELVQADSPTHRVGGLVLDGFEKYQHEYPLYSLQDAFSREELDAFDKRIKSEFPNADYMAELKIDGLSISLTYVDGILQVGATRGDGSVGENITENVKRISDIPLKLDQPLNITVRGECYLPRAEFERINTQRQENGEAEFANPRNAAAGTLRQLDTKVVAERRLATFFYQEAGPTERLTQNDVLNEVAELGFSVNPRRIVTSSMDEIWDFIQAVGQDRDHLAYDIDGVVIKVNSLAMQEELGFTVKAPRWAIAYKFPAEEKEAKLLSVDWQVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYITEKDIRIGDTVIVYKAGDIIPAVLRVVESKRTTQEAMPVPSQCPSCGSGLLHFEDEVALRCINPSCPAQIKEGLIHFASRDAMNISGMGPSVVEKLFKAELVKEVADIYGLNSQDFLQLEGFKEKSAEKLYAAIQASKENSAEKLLYGLGIRHVGAKVSKQLLESFGTIKELASADVQAIAAVDGLGEVIAKSIQRYFAKEEAQVLLKELESYGVNLSYLGQKVTDDAILSGKTVVLTGKLEHLKRSEAKAKLEALGAKVTGSVSKKTDLVVAGSDAGSKLEKAQSLGIEVKDEAWLLDL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DER_ENTFA
Sequence: MANPTIAIVGRPNVGKSTIFNRIAGVRISIVEDTPGVTRDRIYTTGEWLGREFSIIDTGGIDLGDEPFMDQIKHQAEIAIDEADVIIFVASGREGITDADELVAKILYRSNKPVILAVNKVDNPEMRNDIYEFYALGLGDPFPVSGSHGLGIGDVLDEAVKHFPNTSEEEDEDTIKFSLIGRPNVGKSSLINAILGEDRVIVSDIEGTTRDAIDTYFESEEGQKFLMIDTAGMRKRGKVYESTEKYSVMRAMRAIERSDIVLMVLNAEEGIREQDKRVAGYAHEAGRGIIIVVNKWDTVKKDTNTMRDFEAEIRDEFQYLDYAPIIFVSALTKQRLNKLPELIETVSMNQNLRIPSALLNDVVMDAVAINPTPTDKGKRLKIFYATQVAVKPPTFVIFVNEEELMHFSYARFLENQIRKAFTFEGTPIKIIPRRRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: CYAC_BORBR
Sequence: MLPSAQAPSLLNPTDDFAALGNIAWLWMNSPMHRDWPVHLLARNTLAPIQLGQYILLRCNDVPVAYCSWALMDADTELSYVMAPSSLGGNAWNCGDRLWIIDWIAPFSRDDNRALRRALAERHPDSVGRSLRVRRGGDTARVKEYRGRALDAAAARAQLDRYHAELIAGLRASNGGYAPRGRGTA
What is the function of this protein?
Protein-lysine palmitoyltransferase that catalyzes palmitoylation of the protoxin (CyaA) at two internal lysine residues, thereby converting it to the active toxin.
What are the official names of this protein?
Protein-lysine palmitoyltransferase CyaC, Cyclolysin-activating lysine-acyltransferase CyaC.
What is the protein family that this protein belongs to?
Belongs to the RTX toxin acyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACD1_STRMU
Sequence: MTLTQEKRSYMEKLSDENGIISALAFDQRGALKRLMAQYQTQEPTIAQMEELKVLVAEELTPYASSMLLDPEYGLPAAKHLDKNAGLLLAYEKTGYDTTSTKRLPDCLVEWSAKRLKKQGADAVKFLLYYDVDGDEEVNQQKQAYIERIGSECKAEDIPFFLEILAYDETITDAASVEYAKVKPHKVLDAMKVFSDERFGIDVLKVEVPVNMKYVEGFGDGPIVHTQDQAANFFKQQDQATPLPYIYLSAGVSAKLFQDTLVFAKESGANFNGVLCGRATWAGSVKDYIEKGEAAARQWLRTEGFKNIDELNKVLKATATSWKER
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase 1, D-tagatose-1,6-bisphosphate aldolase 1, Tagatose-bisphosphate aldolase 1.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: SUN2_MOUSE
Sequence: MSRRSQRLTRYSQDDNDGGSSSSGASSVAGSQGTVFKDSPLRTLKRKSSNMKHLSPAPQLGPSSDSHTSYYSESVVRESYIGSPRAVSLARSALLDDHLHSEPYWSGDLRGRRRRGTGGSESSKANGLTAESKASEDFFGSSSGYSSEDDLAGYTDSDQHSSGSRLRSAASRAGSFVWTLVTFPGRLFGLLYWWIGTTWYRLTTAASLLDVFVLTRSRHFSLNLKSFLWFLLLLLLLTGLTYGAWHFYPLGLQTLQPAVVSWWAAKESRKQPEVWESRDASQHFQAEQRVLSRVHSLERRLEALAADFSSNWQKEAIRLERLELRQGAAGHGGGSSLSHEDALSLLEGLVSRREATLKEDLRRDTVAHIQEELATLRAEHHQDSEDLFKKIVQASQESEARVQQLKTEWKSMTQEAFQESSVKELGRLEAQLASLRQELAALTLKQNSVADEVGLLPQKIQAARADVESQFPDWIRQFLLGDRGARSGLLQRDEMHAQLQELENKILTKMAEMQGKSAREAAASLGQILQKEGIVGVTEEQVHRIVKQALQRYSEDRIGMVDYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGTFAYDQDGEPIQTFYFQASKMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH
What is the function of this protein?
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton.  The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.  Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement.  Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration.  Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly.  The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly.  Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis.  Required for telomere attachment to nuclear envelope and gametogenesis.  May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5.
What are the official names of this protein?
SUN domain-containing protein 2, Protein unc-84 homolog B, Sad1/unc-84 protein-like 2.
What are the subcellular locations of this protein?
Nucleus inner membrane; Single-pass type II membrane protein. Nucleus envelope. Endosome membrane; Single-pass type II membrane protein. Note=Colocalizes with KASH5 at sites of telomere attachment in meiocytes.
Protein: ACBP5_ARATH
Sequence: MAHMVRASSGLSYPERFYAAASYVGLDGSQSSVKQLSSKFSNDTSLLLYTLHQQATLGPCSIPKPSAWNPVEQSKWKSWQGLGTMPSIEAMRLFVKILEEADPGWYPRTSNSVLDPAVHVQINSTKAEPSFESGASFGETKTITSEDGRLTETQDKDVVLEDPDTVSVYNQWTAPRTSGQPPKARYQHGAAVIQDKMYMYGGNHNGRYLGDLHVLDLKNWTWSRVETKVVTGSQETSSPAKLTHCAGHSLIPWDNQLLSIGGHTKDPSESMPVMVFDLHCCSWSILKTYGKPPISRGGQSVTLVGKSLVIFGGQDAKRSLLNDLHILDLDTMTWEEIDAVGSPPTPRSDHAAAVHAERYLLIFGGGSHATCFDDLHVLDLQTMEWSRHTQQGDAPTPRAGHAGVTIGENWYIVGGGDNKSGASKTVVLNMSTLAWSVVTSVQEHVPLASEGLSLVVSSYNGEDIVVAFGGYNGHYNNEVNVLKPSHKSSLKSKIMGASAVPDSFSAVNNATTRDIESEIKVEGKADRIITTLKSEKEEVEASLNKEKIQTLQLKEELAEIDTRNTELYKELQSVRNQLAAEQSRCFKLEVEVAELRQKLQTMETLQKELELLQRQRAVASEQAATMNAKRQSSGGVWGWLAGTPPPKT
What is the function of this protein?
Binds medium- and long-chain acyl-CoA esters with very high affinity.  Can interact in vitro with oleoyl-CoA, barely with palmitoyl-CoA, but not with arachidonyl-CoA.  May function as an intracellular carrier of acyl-CoA esters (By similarity).
What are the official names of this protein?
Acyl-CoA-binding domain-containing protein 5, Acyl-CoA binding protein 5.
What is the protein family that this protein belongs to?
Belongs to the ACBP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP26A_ARATH
Sequence: MANPKVFFDLTVDGKPAGRIVIELFADLTPRTAENFRGLCTGERGIGKCGKPIHYKGSTFDHIVPDLMWCGGDIIFENEPIHSEELDDEYFILNHEDGPGIISMADSNGSQFQIHMKDYGLQVDGDHVVIGKVVEGLDLMRNIEKEVITTTTRTPSKPVVIADCGELSDYRSERCYLMKNIEKEVIIKTAKDNKPVVIADCGGLSDDRSERYYLINIVVACMVLMCFWSWFV
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase CYP26-1, PPIase CYP26-1, Cyclophilin of 26 kDa 1, Cyclophilin-26-1.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MTP_BOVIN
Sequence: FLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGIQVVIEAQGLEALIAATPDEGEENLDSYAGLSALLFDVQLRPVTFFNGYSDLMSKMLSASSDPMSVVKGLLLLIDHSQELQLQSGLKANMDVQGGLAIDITGAMEFSLWYRESKTRVKNRVSVLITGGITVDSSFVKAGLEIGAETEAGLEFISTVQFSQYPFLVCLQMDKEDVPYRQFETKYERLSTGRGYISRKRKESLIGGCEFPLHQENSDMCKVVFAPQPESSSSGWF
What is the function of this protein?
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:8876250).  Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity).  May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
What are the official names of this protein?
Microsomal triglyceride transfer protein large subunit.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum.
Protein: KGX4A_CENSC
Sequence: DRDSCVDKSRCGKYGYYGQCDECCKKAGDRAGTCVYYKCKCNP
What is the function of this protein?
Reversibly blocks Kv11/ERG potassium channels.
What are the official names of this protein?
Potassium channel toxin gamma-KTx 4.10, CsErgTx4, CsErg4, ErgTx4, Ergtoxin-like protein.
What is the protein family that this protein belongs to?
Belongs to the ergtoxin family. Gamma-KTx 4 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DFP2_ANTMY
Sequence: LSWSALALTSAYPTGAPTSACFDMIPGHFASPQSEPAPYIITTPVSAVKAGDSIEVTISGKTAKDTMRGILLEARQGDKIVGTWTVKPNDNFSQLLNCGEPGNAVTHKHHANSEDKQTVSYLWTASGHLEGDVVFKVTIVKDYHTFWVAVPSAPVKILSHH
What is the function of this protein?
May have antimicrobial activity.
What are the official names of this protein?
Putative defense protein 2, DFP-2.
What is the protein family that this protein belongs to?
Belongs to the insect defense protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RF2_STRGG
Sequence: MAVVDISEELKSLSSTMGSIEAVLDLDALRADIAALEEQAAAPSLWDDPEAAQKITSKLSHLQAEVRKAETLRGRIDDLEVLFELAADEGDADAQAEAEAELESVRKALDEMEVRTLLSGEYDAREALVTIRAEAGGVDAADFAEKLQRMYLRWAEQHNYKTEVYETAYAEEAGIKSTTFAVQVPYAYGTLSVEQGTHRLVRISPFDNQGRRQTSFAGVEVLPVVEQTDHIEIDESELRVDVYRSSGPGGQGVNTTDSAVRLTHLPTGIVVSCQNERSQIQNKASAMNVLQAKLLERRRQEEQAKMNALKGDGGNSWGNQMRSYVLHPYQMVKDLRTEFEMGNPEAVFNGEIDGFVEAGIRWRKQSEK
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_BACMK
Sequence: MPKGTGKVIAQNKKAFHDYFIEETYEVGLVLQGTEIKSIRAGRVNLKDAFARIHNGEVWVHNMHINTYEQGNRFNHDPLRTRKLLLHKKEIDKLAGYAKETGYALVPVRIYLKNGFAKMALGLAKGKKQYDKRHDLKEKEAKREIARVFRDRQKM
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.