PharMolix/UniProtQA huggingface dataset:
Protein: IL12A_BOVIN
Sequence: MCPLRSLLLISTLVLLHHLPHLSLGRSLPTTTASPGRSCLDYSQNLLRAVSNTLQKARQTLEFYSCTSEEIDHEDITKDKTSTVEACLPLELATNESCLASRETSFITNGHCLASGKTSFMTTLCLRSIYEDLKMYHVEFQAMNAKLLMDPKRQIFLDQNMLAAIAELMQALNFDSETVPQKPSLKELDFYKTKVKLCILLHAFRIRAVTIDRMMSYLSSS
What is the function of this protein?
Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine.  IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity.  Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits.  Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2.  In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity).  As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity).  Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers.  Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
What are the official names of this protein?
Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CHED_RHILW
Sequence: MMTEGAARRVHIIQGEYKVLSDPNAVLSTILGSCVAACLRDPVAGIGGMNHFLLPGSATSPTSGGDATRYGVHLMELLINGLLKQGARRDRLEAKIFGGAKTISTFSNVGEQNAAFAMQFLRDEGIPVVGSSTGGDHGRKLEFWPVSGRARQYPLTGAETQRTVALEQRPAAPPKPVETSIEFF
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: LDB7_YEAST
Sequence: MSGSNMGYYDVLAGLSALEKSSQVVFSATELQQLTQQSHATDKGIEGSENSKAKVSKPKRVAVHGYLGGKVSLADAAQVEYEVGHSLLGSYVPRQQLEALSSVDFSHHFHRTLECKAALETHDVFLAGAGQLSLPFQSHIESPRNSEAKRKRKVIICKRCQSRFIGSHRRSQLREHACVD
What is the function of this protein?
Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning.  RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA.  The reaction requires ATP and involves an activated RSC-nucleosome intermediate.  Remodeling reaction also involves DNA translocation, DNA twist and conformational change.  As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.  Together with HTL1, NPL6, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity.  May be involved in the transfer of mannosylphosphate (MP) groups into N-linked oligosaccharides.
What are the official names of this protein?
Chromatin structure-remodeling complex protein RSC14, Low dye-binding protein 7, Remodel the structure of chromatin complex subunit 14.
What are the subcellular locations of this protein?
Nucleus.
Protein: ODO2B_ARATH
Sequence: MMMRAVIRRAASNGSSPSLFAKSLQSSRVAASSPSLLSGSETGAYLHRGNHAHSFHNLALPAGNSGISRSASLVSSTLQRWVRPFSAETGDTVEAVVPHMGESITDGTLATFLKKPGERVQADEAIAQIETDKVTIDIASPASGVIQEFLVNEGDTVEPGTKVAIISKSEDTASQVTPSQKIPETTDTKPSPPAEDKQKPRVESAPVAEKPKAPSSPPPPKQSAKEPQLPPKERERRVPMTRLRKRVATRLKDSQNTFALLTTFNEVDMTNLMKLRSQYKDAFYEKHGVKLGLMSGFIKAAVSALQHQPVVNAVIDGDDIIYRDYVDISIAVGTSKGLVVPVIRGADKMNFAEIEKTINSLAKKANEGTISIDEMAGGSFTVSNGGVYGSLISTPIINPPQSAILGMHSIVSRPMVVGGSVVPRPMMYVALTYDHRLIDGREAVYFLRRVKDVVEDPQRLLLDI
What is the function of this protein?
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial, 2-oxoglutarate dehydrogenase complex component E2-2, OGDC-E2-2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, E2K-2.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYI_BURO0
Sequence: MSNKKADSKPQAKYPVNLLDTPFPMRGDLPKREPQWVKEWEERGIYEKIRAASKGRPKFILHDGPPYANGDIHLGHAVNKILKDIVVKSRNMAGFDAPYVPGWDCHGMPIEIQIEKQFGKSLPAAEVMSKARAYATEQIEKQKVGFKRLGVLGDWANPYKTMNFVNEAEEIRALGKIIEKGYVYRGLKPVNWCFDCGSALAEAEVEYKDRTDPTIDVMFAFAEPEKTAHAFGLPALPRAEGGIVIWTTTPWTIPANQALNLHPEIIYALVDTERGLLIIAQERVEACMADFKLTGRVVATAPGVKLANLRFHHPLASAHPGYKRTAPVYLGDYVTTDTGTGVVHSSPAYGIEDFMSCKAHGMTDSDIINPVMGDGRYIESLPLFGGLSIWDANPKVVDALNAAGSLLRSEKYTHSYMHCWRHKTPIIYRATSQWFAGMDVTPQDGGKTLRETALEGIDATAFYPSWGKQRLFSMIANRPDWTLSRQRQWGVPMAFFVHKETGELHPRTLELLEEVAKRVEQSGIEAWQSLDPRELIGDDANLYEKNRDTLDVWFDSGTTHWHVLRGSHKDQLQFPADLYLEGSDQHRGWFHSSLLTASMIDGRAPYKGLLTHGFTVDGEGRKMSKSLGNGIDPHEVANRLGAEIIRLWIASTDYSGELAISEEILKRVTEGYRRIRNTLRFLLANLSDFDFAQHAVPVDEWLEIDRYAVAFSQQLQTELLGHYEKYEFHPVVAKLQTYCSEDLGGFYLDVLKDRLYTSAADSRARRSAQTALYHLTHGLLRVLAPFLSFTAEEAWKVFQPASDTIFTETYYAYPEVAGSAALIEKWALLRDVRGNVTKALEEARTANRIGSSLQAEVAVHASGARYDALTSLGDDLKFVLITSAATVVKVDDEAQESVDVAASKYQKCERCWHYREDVGAHADHPTLCGRCFSNLFENGEIRSAA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Protein: URE2_KLULA
Sequence: MQQDMQNGGPGNTISNLSSALRQVNLGNSNTTTDQSNISIDFNQQQLLEEANQGSINAYNAQQQQQEHLQQQAQQQQLHMQQLQQAQQQQAQQQAHQQQQQVHQVQHQHVQQDHMPIGQSQQQAMYQGPNPIDSSRITKFFQNQPMEGYTLFSHRSAPNGFKVAIVLSELNMHYNTIFLDFNLGEHRAPEFVAINPNARVPALIDHNMENLSIWESGAIILHVVNKHYKETGNPLLWSDSLADQAQINAWLFFQTSGHAPMIGQALHFRYFHSQKVKSAVDRYTDEVRRVYGVVEMALAERREALIMDLDSENAAAYSAGTTPLSQSRFFDYPVWLVGDKITVADLSFVPWNNVVDRIGINIKVEFPEVYKWTKHMMRRPAVIKALRGE
What is the function of this protein?
Plays an important role in the cellular response to the nitrogen source.  URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase.  URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
What are the official names of this protein?
Protein URE2.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: MSH4_CANAX
Sequence: MALASQLSVTDDSAYGFITTNAEIVSKKRKLAQNDDRFEVVMSVYSPKADSMDVGVSVLKLKTLELTLMSFCDSSTFVRTVNQIQVYEPTSIILPEAQSHSQIEKLKYIIHSNISDKVRERFMKAKVFNAFDGMNSLKLYTDINESTLGQVISNRKLSLAAANACIDYCVSTKMFRVTNKIRLKYCMCENTMLIDTCTVRDLELVDSLSETGTTLYSFLNCCLTKMGMRILRTSILQPSTHENSIILRSESLQELINDEDALISIRSSLKHTCDLEKVFSTFLEPRGLLSQEQEINNIILLKTVLQNTFVIRKSIQNVSSHLLVQVKQILEHENVQHLLAIINEYIRNDCQWANNSTELANQRANAVKSGVNGLLDVSRRIRETLLEEVSELVAKLSEELEIFMEYRFEISRGFFIKIKGNNTDINSLPEVLINRVKKRKTIECTTIELMKQSSRYNDIVSEITTLNSTIIHDMYTSINSYTPILLMVSEAIGTLDLLCSFAYFTSLQKDSYTCPEFAKEVTIMRSLHPILGGNNSNFVANNYSCNHELSRIHVITGANMSGKSVYLRQIAYLVIMAQMGCFVPAEYARMRIFNSLYSRISSDNVDINASSFSKEMSETAVILNDSDGDSLILIDELGRGSSLTDGFSICLAILEDLICKEATVITTTHFRDIAQVLANKSCVVTAHMQTVETNGQLEMKYNLVLGRNDIVGYGIRFAEVSNLLPQELIEDSKVVANILRSRKPVHGDKELKLLSRRRKLVLELYFALNYISKLNCDMNYKMQLLQTLQSKFVEEINITPNTE
What is the function of this protein?
Involved in meiotic recombination.  Facilitate crossovers between homologs during meiosis (By similarity).
What are the official names of this protein?
MutS protein homolog 4.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: SCMC2_HUMAN
Sequence: MLCLCLYVPVIGEAQTEFQYFESKGLPAELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
What is the function of this protein?
Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane.  Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it could have a broader specificity for adenyl nucleotides.  By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways.
What are the official names of this protein?
Mitochondrial adenyl nucleotide antiporter SLC25A25, Mitochondrial ATP-Mg/Pi carrier protein 3, Mitochondrial Ca(2+)-dependent solute carrier protein 3, Short calcium-binding mitochondrial carrier protein 2, SCaMC-2, Solute carrier family 25 member 25.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: SWT21_ASHGO
Sequence: MNILAHTGDIFHGRGKLHASLKEQQVWDDLRRPGHDVPQLPRPQGYTASQPIYKRLPVVCRGLTWSFDGSSLVAVHEDCGIRQYAVCEEQGPVMAPVQRFFKPQAIISHAVHPQNSLFQADSSLNVVVVSCKDMPYQLYPLHSNPDQPARALQTYNSASESTEEFRAAYAMDFLDDAHFLAGSTRNTVSLFDASRRESIWVSSATRRGCGRGQHKAIVSCFDEANERRDCVRYAGTYRSELLRIDPRTSSISSWKAIQDKSRGIYQVLQSNNGHYFYIMKRYSNSITVLDSRKSMAIVNQFKLPFQTHAQKLRGTYSTRHGLLIGDEAGRILQWAPEVVEFGGIDRSGSVPSYGIGETGITHVCAEGSRINIIEKNPADSDIFAISYSPDKYGEDVSCNAGILLMRL
What is the function of this protein?
Involved in mRNA splicing.  Helps to stabilize the U1 snRNP-5' splice site interaction (By similarity).
What are the official names of this protein?
Protein SWT21.
What is the protein family that this protein belongs to?
Belongs to the SWT21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNME_BRASB
Sequence: MHPHDQTIFALSSGRPPSAIAIVRLSGVGAGPALQTLTGKLPPPRLATRALLRDDRGDPIDDAVVLWFPGPASATGEDVAELHVHGSRAVITTLVSLLSAMPQMRAADRGEFTRRAFENGKIDLTEAEGLDDLIHADTDRQRRQALRQLKGLLGDKARSWRDQIIQAAALIEAGIDFADEGDVPAELIAPALAWIRQLLAEIEEVLAAQGRAERLRDGLTVVIAGPPNAGKSTLMNQLARREVAIVSPHAGTTRDLIEVALDLDGYPVTVIDTAGIRQTDDPVEQEGVRRARDRAAQADLVLWLTEDDQAELERQTDGPIWFVRNKIDLMITEQSGAISVSPESPVFAISARSGAGMSDLLEALVGFARDYFGATEHGLITRERQRTWLSETAAALRRSIAAVDLGEELAAEELRIAALALGRLLGRVDVEDLLDVIFREFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSPK_BACC1
Sequence: MGKQAEFWSESKNNSKIDGQPKAKSRFASKRPNGTINTHPQERMRAANQQEE
What are the official names of this protein?
Small, acid-soluble spore protein K, SASP K.
What is the protein family that this protein belongs to?
Belongs to the SspK family.
What are the subcellular locations of this protein?
Spore core.
Protein: SOCS5_HUMAN
Sequence: MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLRENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
What is the function of this protein?
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.  May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR.  Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype.  Can also partially inhibit IL6 and LIF signaling.
What are the official names of this protein?
Suppressor of cytokine signaling 5, SOCS-5, Cytokine-inducible SH2 protein 6, CIS-6, Cytokine-inducible SH2-containing protein 5.
Protein: RAB32_HUMAN
Sequence: MAGGGAGDPGLGAAAAPAPETREHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVLNWDSRTLVRLQLWDIAGQERFGNMTRVYYKEAVGAFVVFDISRSSTFEAVLKWKSDLDSKVHLPNGSPIPAVLLANKCDQNKDSSQSPSQVDQFCKEHGFAGWFETSAKDNINIEEAARFLVEKILVNHQSFPNEENDVDKIKLDQETLRAENKSQCC
What is the function of this protein?
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion.  Also involved in synchronization of mitochondrial fission (PubMed:12186851).  Plays a role in the maturation of phagosomes that engulf pathogens, such as S. aureus and M. tuberculosis (PubMed:21255211).  Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991).  In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).
What are the official names of this protein?
Ras-related protein Rab-32.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion outer membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Melanosome membrane. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).
Protein: RL35_WIGBR
Sequence: MLKIKNIRSVCKRFKKTASCNKFKYKKSNLRHILTKKSTKRKRKLRIKSFATKGDKKLILRCLPYK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: PEPQ_SALHS
Sequence: MESLAALYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEVEVVALPKADGIGSQLPAARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHYYRAYKTDYELACMREAQKMAVSGHRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPSKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREGPFSKHFNWQKIEALKPFGGIRIEDNVVIHENGVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: RS12_YERPP
Sequence: MATINQLVRKPRSMKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQSRSKYGVKKQKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SYH_STAAB
Sequence: MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVVQKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGRYRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNEALVKHFEPVIHEFCSDCQSRLHTNPMRILDCKVDRDKEAIKTAPRITDFLNEESKAYYEQVKAYLDDLGIPYIEDPNLVRGLDYYTHTAFELMMDNPNYDGAITTLCGGGRYNGLLELLDGPSETGIGFALSIERLLLALEEEGIELDIEENLDLFIVTMGDQADRYAVKLLNHLRHNGIKADKDYLQRKIKGQMKQADRLGAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFIT2_CRIGR
Sequence: MSTTTKKSLESKLQQLKCHFTWNLMAGDESLDEFEDKVFNKDEFQKRECKATMCNILAFVKHRRGQNASALKELEKAEQFIQQQHPDHVEIRNIVTWGNYAWVYYHMGQLEKAQAYLDKVRQVCEKFSSPYRIESPELDCEEGWARLKCTRNQNERVKVCFEKALEKDPKNPEFTSGWAISNYRLDFWPAQQNAVDSLKQAIRMSPNSPYVKVLLALKLEMNQENQGKELVEEALREAPGETDVLRSAARFYYKTHDKDRAIQLLSQALELLPNNAYVYYYIGCFYRSKVLQIDSRRETSQNENREQLLKQAIYYLKKAEETKEMIKDSCSYLAHLYVLAEQYKEADYYFQKGFKKELTPGLKQLLHLRYGNFQFFQMKCEDKAIHQYLEGVKIRQKTKPKEKMTNKLRFIAERRRSQNGFDSKALHILAFLQELNKESQQAAKVSERGQDSERPVFSPSLHEGGNEQ
What is the function of this protein?
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap.  The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection.  Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism).  Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity.  Can promote apoptosis (By similarity).
What are the official names of this protein?
Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, CL-54 K, Interferon-induced 54 kDa protein, IFI-54K.
What is the protein family that this protein belongs to?
Belongs to the IFIT family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: DLTC_STAA3
Sequence: MEFREQVLNLLAEVAENDIVKENPDVEIFEEGIIDSFQTVGLLLEIQNKLDIEVSIMDFDRDEWATPNKIVEALEELR
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_ESCF3
Sequence: MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGITVYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIAIPPSLLNMYKELENTIPGFTRPGHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRHHVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQRGEKPIDWMPVLPAESE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y6476_DICDI
Sequence: MYRNILRKLKRQINTILKIYIFIKKHEHHLRKLFVIFQVIISIVLLSLSVTTNDHDHLFDSWYYFASHLILSLFGIFVFFKKSTNSKLLYLYVILLSGLLITASFSFFWYSGELNIIENTCISDQCNHDRAYYRKKTYKIIALIVVEGVALHPNLSWLIQVLKKERKLKQLNTINNTNDTAIRSPSLNNISGNNNNNINNNNINNSNNNINNTSYNNDYFNNHNIINNNKNNIYNNNNKINSELQPPSILNKNSKPIE
What are the official names of this protein?
Uncharacterized transmembrane protein DDB_G0276999.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FMT_TREPA
Sequence: MVRVFFAGTPECAVPSLRRVACAHRVVGVLTNPPAAVGRSGKLVHSAVAREFFRLKASGVLPESASLFVPGRLDRAFYDAVEALRPDVLVCFAYGKIFGPRFLALFPRGAINVHPSLLPRWRGSTPVPAAILAGDCETGVTLQYIGEEMDAGDILAQSRVQLDGTETTGALLSRLSLVAADLVDDVLVGVERHTLAPAAQDHSQATFCGKLCREMGLADWSNPAVVLERKIRAFTPWPGLFTYKDGERIAILQARSCESSFVPLAPVGTVLAADKNGVFVQTGDGVLSLLQLQRSGKKPLFWRDFLNGSPLLLTGRLGV
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: OL490_MOUSE
Sequence: MAFLENGNHTAVSEFILLGLTDDPVLRIVLFTIILCIYLVTVSGNLSTILLIRVSSQLHHPMYFFLSHLASADIGLSSSVTPNMLVNFLVERSTISYLGCGIQLSSAALFGATECFLLAAMAYDRFMAICNPLLYSTKMSTKVCVQLIVGSYIAGFLNASSFLLSFFSLLFCGQNIINDFFCDFAPLAELSCSDVSVFVVVISFSAGTVTMLTVFVIAISYSYILITILKMRSTEGRQKAFSTCTSHLTAVTLFYGTVTFIYVMPKSSYSMDQNKIISVFYMVVVPMLNPLIYSLRNNEIKGALKRHFDRKTFS
What is the function of this protein?
Potential odorant receptor.
What are the official names of this protein?
Olfactory receptor 490, Olfactory receptor 204-17.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.