PharMolix/UniProtQA huggingface dataset:
Protein: DTD_PSEFS
Sequence: MKGLLQRVRGARVEVAGEIVGAVDQGLLVLVAVEPSDTPESADKLLHKLLNYRVFSDDEGKMNLSLKDIDGGLLLVSQFTLAADTKSGLRPSFSTAAPPALGAALFDHLLLQAQQLHGKVASGRFGADMQVHLVNDGPVTFLLQT
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_ACIBT
Sequence: MPRRRVVAAREILPDPKFSSQTIAKFMNHVMQDGKKSIAESIVYGALERVQEKNKVDPVEFFETTLEKVRPMVEVKARRVGGATYQVPMEVRPSRRTALAMRWLVDAAAKRSEKTMALRLAGELLDAAEGKGAAIKKREDVHRMAEANKAFSHYRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: LEUD_RHIEC
Sequence: MDKFVKLTGVAAPLPVVNIDTDMIIPKDYLKTIKRTGLGKGLFAEARYNEDGSENPDFVLNKPAYRDAKILVAGDNFGCGSSREHAPWALLDFGIRCVISTSFADIFYNNCFKNGILPIKVSQENLDKLMDDASRGSNAILTVDLENLEITGPDGGSIKFDLDEFKRHCLLNGLDDIGLTLEKGKAIDEFEKKNAASHPWAA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RUVB2_CRYNJ
Sequence: MAANISLQPTSMRDVTKMERIGVHSHIHGLGLDSNLEPRASSQGMIGQGKARKAAGVILKMVQEGRIAGRAILMAGPPSTGKTALAMAMTQTLGSDVPFVMLTASEVFSLEISKTESLTQAFRRAIGVRIKEETELIEGEVVEIQVDRSVTGATKTGRLTLKTTDMETVYDLGSKMIDQLQKEKVLAGDVVSIDKASGRISKLGRSFGRAKDYDAMGADTRFVACPDGELQTRKEVVHTVSLHEIDVINSRTQGFLALFAGDTGEIKPELRAQINGKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRAMENELAPLVVMASNRGITRIRGTKYKSPHGIPADLLDRMLIISTNRYEEDEMREIVKIRAEEEDVRLSPAALDLLATMGIQTSLRYSLNLIAPSSLLAQRRKSPQTDVEDVRMAYKYFCDVERSAQYAKETSGMMFGETEEINGGMEVDA
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair.  Also involved in pre-rRNA processing (By similarity).
What are the official names of this protein?
RuvB-like helicase 2.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARGC_DEIRA
Sequence: MNKPKIFIDGEAGTTGLQIRERLAGRSDLELLSIDPVRRKDSAARAELLNAADVSILCLHDDAAREAVSLTTNPASRLLDASTAHRIHPDWVFGFPELSAEQPEKIRQARYVANPGCYSTGAIALLAPLTGRGLLPADFPVHIQGYSGYTGGGRALVDAHEQGSAHPSKGAFISYGLTLEHKHLPETMVYGGLTRKPVFTPNVGGWAQGMTVTVPLHLAELGVSAEALHAALKEHYAGQQYVKVFELADNPEILDPQTLNGTNNLELFVYPAADGERALLAARLDNLGKGASGAAVQNLELMLGLS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTLR_STRMU
Sequence: MLLTKREKHLLAAFQNYGKLSLKQMIDLLKVSQRTVYRTISDLTDSLNTINISIIKENQNYFLVGELANLASIISLDTYEQYERLNLITYKLLMSFSSITNEQLQEEFNVSNVTIIQDIAEIEKRLADFDLRLDRKKGYRLVGNKNTLRRLLAILLTNNLSISDFGAGAYGHFEVLDKAKLELAKQIFQSSQEDLPDLDAKMSEFFIILLALSGWRDNEAVGHSISKAALDFSQKVYTEFSQKTNQFYSIQEILYYASILDELVIKRQETPLFHEKFDSAFFYNISNLIDKVSLYTKINFAKDKTLFHFLFNHIRLNLAVPQIFEDKSNNTIAHEVVQGNEYLHRVVSLLVQDIFPKYLQKEPEYELITLHFASSLRRSPDIYPIKILLLTDERPLARELLITRIKTIAPFVDKVVVKELAQYETKDKDYYNCVLATKPLVDKAVKMVSTYPDAKEMLQLQDYLQNVQAHQKIIIRDEQTNKQGYNLQNYFLATQQLLQEFSYQEIDNPADFETSVPKIMETIAAVSDKTYLSSKLLKCFAVSPLAIPETHLALLHTQSSKVITSCFKIYDLKRPVTALSMNYEKETVTRILVMLTRLDETKEMRDLMTAISQSIIENHLYTEIYKTGNKDIIYQLLNQIFTEKIKKLET
What is the function of this protein?
Not necessary for mannitol utilization.  May be involved in regulation of the mannitol phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).
What are the official names of this protein?
Putative transcriptional regulator MtlR.
Protein: Y1822_AQUAE
Sequence: MELDLISYELDEKTKEGIEKVVEKFFTKAEPDLVLIFDKAGRILACKGMDISDTYSEFISSILSALFFASEELTSMLDKNDEMKDVFYETKNRVFLMARLEKDFLIGVISRKNLSLGSIRLFFNHLVSDLNAVLKNLKEVEKKSLKISKEELKKKLDQILGS
What are the official names of this protein?
Uncharacterized protein aq_1822.
Protein: Y840_NEIMB
Sequence: MFEQEDEWISKTQMKKQMNDLQDLGMALTKLSNDTLKKIGLDADLYEAVTAYKKITSNGALKRQAQFIGRLMRDTDPAPIEAFLAKLRGDDAAHNAFLQRVEQARVRLLADDGALTQFMSDFPHADAGKLRTLIRNTKKEQEQNKPPKNFRALFQELKTVMENGDAEI
What are the official names of this protein?
UPF0307 protein NMB0840.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: ANR54_MOUSE
Sequence: MAATGGGADDESRSGRSSSDGECAVAPEPLAEAGGLVSFADFGVSLGSGAGLPGRSVGRAQSSLRYLQVLWQQDVEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQQDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHSQCLEAVRLEVKQIIHMLREYLERLGRHEQRERLDDLCTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEKR
What is the function of this protein?
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
What are the official names of this protein?
Ankyrin repeat domain-containing protein 54, Lyn-interacting ankyrin repeat protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Midbody. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation.
Protein: RIX1_KLULA
Sequence: MATVTVPLSSLAKLIEESEGSQFRSILQTLRSPTYVNQSLLKSDIGVFVAKLLKLLRSSEPYQIWKGCHAVAVLCSNNPVVLCSQANQFLTVLYTRLESFINFYVETSQSAARLTTLKTLTRTVDILMDLIRGKPTLTREALTPKLNAVIPLLMTLCQYEPELCLPILKKLLLQNTTTFKPFANKYRVILNRLITKDFQLYDRTTQRLICDNFAYLHLIKQNAQKLEENQEHHKTLMDENWRSSILSVLYQFKPLILLCGDILDFSVDSEMLNFIDSLPTPKKDTGEIKDELFAPLSVDMNESFSLWEISYRVEVLSQLLISFISLPTSFPLRIPLHGIIDICQALLMLSTNYLPLKRGLRRETELTAVIITVLRSLQYQGIVVLKSISRCYGKDILYYYSSILSSLELFIPIKARGNAIDYEKVESMKEQVFDLLSLINTLAGHLGHKIDELDLFTKLTDITLRLVEEKSNLGKFYTTVNDAKSIKQTTKQKKDYNKMAGAMSDIYSHPKQFVNKTELRWYDEANKFLSLVVQNWKLPSTQQVNIIKYATVMSITLNEQIGNIPESFEELLTTIVLYPGSERLSILPIAVGLLKNMDNKVFDVLCNPRLPFSCLLNPGSSSIRKDIRNALKMPNGDSDETEETIVTGQQDVLDQSDANGIVTANDIERDRDGPENSIEKPLSALTSIVSDESQIFRKRAVEESESEEEETKRQRPDSAEETENNGETVVIPNVPTQVLQTVETTETAQQPDSDSDSEIEIPTINVSDNDDDDDEE
What is the function of this protein?
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits.  Regulates pre-60S association of the critical remodeling factor MDN1.
What are the official names of this protein?
Pre-rRNA-processing protein RIX1.
What is the protein family that this protein belongs to?
Belongs to the RIX1/PELP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURD_MYCBT
Sequence: MSGLPRSVPDVLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCX3_CENEX
Sequence: AKDGYLVNKSTGCKYECFWLGKNEFCDKECKAKNQGGSYGYCYSFACWCEGLPESTSTYPLPNKSCGRK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Neurotoxin Cex3.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MURG_STAA3
Sequence: MTKIAFTGGGTVGHVSVNLSLIPTALSQGYEALYIGSKNGIEREMIESQLPEIKYYPISSGKLRRYISLENAKDVFKVLKGILDARKVLKKEKPDLLFSKGGFVSVPVVIAAKSLNIPTLIHESDLTPGLANKIALKFAKKIYTTFEETLNYLPKEKADFIGATIREDLKNGNAHNGYQLTGFNENKKVLLVMGGSLGSKKLNSIIRENLDALLQQYQVIHLTGKGLKDAQVKKSGYIQYEFVKEDLTDLLAITDTVISRAGSNAIYEFLTLRIPMLLVPLGLDQSRGDQIDNANHFADKGYAKAIDEEQLTAQILLQELNEMEQERTRIINNMKSYEQSYTKEALFDKMIKDALN
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: XYLC_CAUVC
Sequence: MTAQVTCVWDLKATLGEGPIWHGDTLWFVDIKQRKIHNYHPATGERFSFDAPDQVTFLAPIVGATGFVVGLKTGIHRFHPATGFSLLLEVEDAALNNRPNDATVDAQGRLWFGTMHDGEENNSGSLYRMDLTGVARMDRDICITNGPCVSPDGKTFYHTDTLEKTIYAFDLAEDGLLSNKRVFVQFALGDDVYPDGSVVDSEGYLWTALWGGFGAVRFSPQGDAVTRIELPAPNVTKPCFGGPDLKTLYFTTARKGLSDETLAQYPLAGGVFAVPVDVAGQPQHEVRLV
What is the function of this protein?
Involved in the degradation of D-xylose (PubMed:22709678, PubMed:25073011).  Catalyzes the hydrolysis of D-xylonolactone to D-xylonate (PubMed:25073011, PubMed:34633186).
What are the official names of this protein?
D-xylonolactone lactonase, Xylono-1,5-lactonase.
What is the protein family that this protein belongs to?
Belongs to the SMP-30/CGR1 family.
Protein: RUVB_YERPN
Sequence: MIEADRLISAAVINDEESIDRAIRPKLLTEYVGQPHVREQMEIFIQAAKQRGDALDHVLIFGPPGLGKTTLANIIANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVADLEHIVSRSAKCLGLELTPEGAHQLARRSRGTPRITNRLLRRVRDFAEVRADGAINGEVAMKALDMLNVDAEGFDFMDRKLLLAVIDKFMGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFIQRTPRGRIATNHAYKHFGITREE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: F124B_HUMAN
Sequence: MDETQGPLAMTVHLLANSGHGSLLQRTLDQLLDCICPEVRLFQVSERASPVKYCEKSHSKRSRFPGMSVLLFLHESPGEDRLFRVLDSLQHSPWQCYPTQDTRGRLCPYFFANQEFYSLDSQLPIWGVRQVHCGSEILRVTLYCSFDNYEDAIRLYEMILQREATLQKSNFCFFVLYASKSFALQLSLKQLPPGMSVDPKESSVLQFKVQEIGQLVPLLPNPCMPISSTRWQTQDYDGNKILLQVQLNPELGVKNGILGAGMLPLGSRLTSVSAKRTSEPRSQRNQGKRSQGHSLELPEPSGSPTSDRCAGTSWKSPGRSFQVSSPAMGAHLHLSSHHLESGARMKVLNRENSFQKLEAETNVDTGLTIINSEPRQTYFGGFPRDLQTSQPPFCLPASSLGVATSKNNSVLKERVSPLPLAGQRDLGTRKTISECLLHLQVQGEEKEEDEEEFFI
What are the official names of this protein?
Protein FAM124B.
What is the protein family that this protein belongs to?
Belongs to the FAM124 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GRP4_MOUSE
Sequence: MNRKDIKRKSHQECSGKAGGRGRSRQARRHKTCPTPREISKVMASMNLGVLSESSCSEDELLEECIRCFDSAGSLRRGDHILKMVLTMHSWVLPSSELAARLLTSYQKAAKDAQELRQLQICYLVRYWLTHHHEAVHQEPQLEAVISRFWTTVAQEGNMAQRSLGDASSLLSPGGPGPPPPMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAHYRRTWAGCTGFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELMALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFKAPVVVEWAQGVTPKPDSVTLGQHVEQLVESVFKNYDPEGRGSISLEDFERLSGNFPFACHGLHPPPRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCSGFLWGVTKQGYRCRDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPVPATSLPPANCGSEESLSYTLSPDPESGCHLRHAWTQTESSHSSWEPEVVPCPARVLPSRASSKPSV
What is the function of this protein?
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP.  May function in mast cells differentiation.
What are the official names of this protein?
RAS guanyl-releasing protein 4.
What is the protein family that this protein belongs to?
Belongs to the RASGRP family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG.
Protein: AMPA_CHLTE
Sequence: MKCTVTAKESGLVNADILVQFFSKKEMKRDAGKVLAGLGVVASPDGDFKASAGEIAMLYRQASGKEASRVILAGVGEGKTAEDYRKAADSVARKTVDLHLGVLALDCSPIDDWAKQSKQKPEELAAILVEGVLSGAYRFDRLKSGKLDKEETKEDKPKNIEELVLAGCGSRLEAIEKGAGKGMIIGACQNRARDLVNLPGNHLSAEDLAEAAIEAGKRGGFEVTVFDKKKIVELGMGGLLAVNKGSEQPPTFVILDYKPKGKAKKTIALVGKGVTFDSGGISLKPAQGMDEMKSDMSGAAVVIAAIEAAASLGLPLRVVGLVPATDNMPGGSAQKPGDVITTMSGITVEVGNTDAEGRLILADALFYAKKEYNPDVIIDLATLTGACIVALGNSVAGLFSNDEKLAESIFEAGQSSGEKVWRLPLWDEYDELIKSDVADVHNTGGRGAGTITAAKFLEKFIDGHKHWAHIDIAGPAFWAKGGSKTPGATGFGVRLLLDLLKGWS
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_PARPJ
Sequence: MAVFTAVTEPQLAEWMSHYDLGDVVEFRGISSGIENSNFFLTTTRGEYVLTIFEKLTAEQLPFYLDLMRHLAAHRVPVPDPMPREDGALFGTLHGKPAAIVTKLEGAPELAPGVEHCIEVGQMLARMHLAGRDYTGYQPNLRSLPWWRETVPTILPFLQGEQRELLSSELAHQEAFFASADYAALPEGPCHADLFRDNAMFAHAAPDTGHEVRLGGFFDFYFAGCDKWLFDVAVTVNDWCVDLATGKLDNARTEAMLRAYQTVRPFTAEENRHWGDMLRAGAYRFWVSRLYDFYLPRAAELLKPHDPGHFERILRERLTGVALPGIHTSCN
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: HIS6_HALOH
Sequence: MLTKRIIPCLDVKGGRVVKGVNFKDLRDEGDPVELARYYDREGADELVFLDITASAENRGIVIDMVEKTAASVFIPFTIGGGIRTISDMKAILNAGADKVSINSAAVKNPGLIAEGARVFGSQCIVVAIDCCRKNGNWEVYINGGRTVTGLDAIKWAQKVEELGAGEILLTSMDADGTKDGYDTELLAAVSTAVEIPVIASGGAGMPEHLREAIVEGQADAVLAASIFHEKTYSVSEVKEYLAGHGIPVRIE
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAST_ANTFM
Sequence: INLLKIAKGIIKSL
What is the function of this protein?
Mast cell degranulating peptide.  Also permeates anionic liposomes.  Has little hemolytic activity.  Has an amphiphilic alpha-helix conformation.  Shows broad-spectrum antimicrobial activity against the Gram-positive bacteria S. aureus ATCC 6538 (MIC=5 ug/ml), S. saprophyticus CS (MIC=5 ug/ml), S. epidermidis CS (MIC=5 ug/ml), B. subtilis CCT 2471 (MIC=40 ug/ml), and the Gram-negative bacteria E. coli CCT 1371 (MIC=20 ug/ml), E. coli ATCC 25922 (MIC=50 ug/ml), and P. aeruginosa ATCC 15442 (MIC=20 ug/ml).  Blocks the lobster neuromuscular transmission.  Induces the depolarization of the muscle membrane.
What are the official names of this protein?
Eumenine mastoparan-AF, EMP-AF, Af-113.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Mastoparan subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Assumes an amphipathic alpha-helical conformation in a lipid environment. Forms a membrane channel in the prey (By similarity).
Protein: BR1A_RANTE
Sequence: FITLLLRKFICSITKKC
What is the function of this protein?
Antibacterial activity against representative Gram-negative and Gram-positive bacteria and exhibits a very high hemolytic activity.
What are the official names of this protein?
Brevinin-1Ta.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: RL35_CHLMU
Sequence: MPKMKSNKSVAARFKLTGSGQLKRTRPGKRHKLSKRSSQQKRNLSKQPLVDQGQVGMYKRMMLV
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: TAL_CLOD6
Sequence: MRFFIDTANIEEIKEANDLGVICGVTTNPSLIAKEGRDFIEVVKEISEIVDGPISAEVISLEHKGMIEEAEKLSKIHKNIVIKIPMTAEGLKAVKVLSSKGIKTNVTLIFSAGQALLAARAGATYVSPFVGRLDDISQNGLDLIEEIVDIFSVNSIEAQIIVASVRNPIHVLQAARMGADIATVPLKVINQMIKHPLTDKGIDSFMKDWEGASLKL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRP54_SULIK
Sequence: MLENIRDAVRKFLTGSTPYEKAVDEFVKELQKSLISSDVNVKLVFSLTAKIKERLNKEKPPSVLERKEWFISIVYDELSKLFGGDKEPNVNPTKLPFIIMLVGVQGSGKTTTSGKLAYFYKRRGYKVGLVAADVYRPAAYDQLLQLGNQIGVPVYGEPNNQNAIEIAKKGVDTFVKNKMDIIIVDTAGRHGYGEETKLLEEMKEIYEALKPDDVILVIDASIGQKAYDLASRFHQASPIGSIIITKMDGTAKGGGALSAVAATGATIKFIGTGEKIDELEIFNAKRYVSRILGMGDIESILEKVKGLEEYEKIQKKMEDVMEGKGKLTLRDVYAQIMALRKMGPLSKVLQHIPGLGVMLPTPSEDQLKLGEEKIRRWLAALNSMTYKELENPSIIDKSRMRRIAEGSGLEVEDVRELLEWYNNMNKLLKMVKRRRGSIDKLFGGKIG
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle 54 kDa protein, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: LAP2B_MOUSE
Sequence: MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLAAGANSKGPPDFSSDEEREPTPVLGSGASVGRGRGAVGRKATKKTDKPRLEDKDDLDVTELSNEELLDQLVRYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTVSSSAENTRQNGSNDSDRYSDNDEDSKIELKLEKREPLKGRAKTPVTLKQRRTEHNQSYSQAGVTETEWTSGSSTGGPLQALTRESTRGSRRTPRKRVETSQHFRIDGAVISESTPIAETIKASSNESLVANRLTGNFKHASSILPITEFSDITRRTPKKPLTRAEVGEKTEERRVDRDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYAPLADVKSEKTKKRRSVPMWIKMLLFALVAVFLFLVYQAMETNQGNPFTNFLQDTKISN
What is the function of this protein?
May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope.  Possible receptor for attachment of lamin filaments to the inner nuclear membrane.  May be involved in the control of initiation of DNA replication through its interaction with NAKAP95 (By similarity).
What are the official names of this protein?
Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma, Thymopoietin isoforms beta/delta/epsilon/gamma, TP beta/delta/epsilon/gamma.
What is the protein family that this protein belongs to?
Belongs to the LEM family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Single-pass type II membrane protein. Chromosome. Note=Tightly associated with the nuclear lamina.
Protein: RS21_HELHP
Sequence: MPGIKVKESESFEEAYRKFKKQTDRNLVVTEVRARRFFESKTEKRKKQKINAKKKMLKRLYMLRRYESKL
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: YEDF_ECO57
Sequence: MKNIVPDYRLDMVGEPCPYPAVATLEAMPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQQDGPTIRYLIQK
What are the official names of this protein?
Putative sulfur carrier protein YedF.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
Protein: RPPH_ACTP2
Sequence: MIDFDGYRPNVGIVICNKAGQVLWAKRFGQNSWQFPQGGINEGENIETAMYRELYEEVGLTKKDVRLLWASKYWLKYKLPKRLVRSDGSQLVCIGQKQRWFLLQLLSDENLIDLKTTKSPEFDGWRWVSFWYPVRQVVSFKRDVYRKVMKEFAGVLLNESKKPETVEKPRVERTEKRDFQKRDNQKREFRKSARMWNNSHQKGKAQ
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.