PharMolix/UniProtQA huggingface dataset:
Protein: CARB_CLOBB
Sequence: MPLNKDIKKVLVVGSGPIVIGQAAEFDYSGTQACEALKSEGIEVVLINSNPATIMTDKEVADKVYLEPLTLEFIEKVIVKERPDSLLAGMGGQTGLNLAVELHDSGILEKYDVKVIGTSIESIKEGEDRELFRDMMNRIGEPVIKSEIVTDLQSGIDFANKIGYPVIVRPAYTLGGSGGGIADDEEELRIILESGLQLSTIGQVLLEKSVKGWKEIEYEVMRDSYGNCITVCNMENIDPVGIHTGDSIVVAPSQTLSDKEYQMLRTASINIINSVGIEGGCNVQFSLNPNTFEYAVIEINPRVSRSSALASKATGYPIAKLAAKIALGYGLDEIKNAVTQKTYACFEPTLDYVVVKIPKWPFDKFFGADRQLGTKMMATGEIMAIGANFEQAFLKGIRSLEIGKYSLDHKKFKEHSMSELKDLVMKPDDERIFALAEMLRRDYMIERINKITGIDKFFLEKIKWIVEEEQRLKLSKIEDLDKEWLQNLKKKGFSDKAIADMLKVSPEDIYRLRDIWSIKPSYKMVDTCGGEFEALSPYYYSTYEQYDEVEVSNRRKVIVIGSGPIRIGQGIEFDYASVHCVKALKKLDIETIIVNNNPETVSTDFDISDKLYFEPLTEEDVLNIIEKENPYGVILQFGGQTAIKLANFLKEKNIKTLGTTADQIDMAEDREKFDELLERLDISRPKGKGIWSVEEGLEEAERLGFPVLVRPSYVIGGQGMEITHDEEELIFYLTNAFVKDKKNPILIDKYLMGREIEVDAISDGENILIPGIMEHLERAGVHSGDSVTMYPSQNVCDEIKGKILEYTKKLALAIGIKGMINIQFIEFEGNLYVIEVNPRASRTVPYISKVSKVPIVDIATQVMMGAKLNDLGYGVDIYKEPELVSVKVPVFSTQKLPNVEVCLGPEMRSTGEVLGVGRNLKEALYKGFVGANMYPSKEKGKILATINKHNKAEFLPIAKDLAKVGYKFIATTGTCKLLREEGIDAEEVRKIDEEKPNILDIVKNREVDLVVNTPTKGNDSKRDGFLIRRAAVERNLGVITALDTLRAIADVELEEFDKNKDLEVFDITK
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: TGT_CLOK1
Sequence: MYKLLKKDGSSRRGEFSTPHGVVQTPVFMNVGTLAAIKGAVSTEDLKEIGCQIELSNTYHLSLRPGDEVIRKLGGLHKFMNWDRPILTDSGGFQVFSLSGMRKIKEEGVYFNSHIDGRKIFMGPEESMRIQSNLASTVAMAFDECVENPAPKEYVEDSVKRTTRWLKRCKIEIDRLNSMPHTINNKQMLFGINQGGVHDDIRMEHAKIISDMDLDGYAIGGLAVGETHEEMYRVLEKVVPNLPENKPIYLMGVGTPANILEAVERGVDFFDCVMPSRNGRHSHVFTSYGVIHLLNAKYELDDNPIDSECSCPTCKNYTRAYIRHLFKAKEMLAMRLCVIHNLYFYNNLMKEIRESIDKGNFLQYKKEKLEKWNETV
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: CLCA_YERPY
Sequence: MTHSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWVQQQRLLALANVADYALLVWPLAFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGRMIVDIFRLRSPEARHSLLATGAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIEVGKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGGMCGLLALLHGNAVGGGFALIPIAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAASVRAPLTGIVLVLEMTDNYQLILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQIGK
What is the function of this protein?
Proton-coupled chloride transporter.  Functions as antiport system and exchanges two chloride ions for 1 proton.  Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
H(+)/Cl(-) exchange transporter ClcA.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YDAK_BACSU
Sequence: MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITFGVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLLFSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERYGNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIVLTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELENEMMMNEL
What are the official names of this protein?
Uncharacterized membrane protein YdaK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LUTC_ALKCK
Sequence: MIKNRDSFLDHVANQLGRPRQTEGVLRPNYRVSPQFEVLKDASKDELVTVLKEQCVAIHTDFKQVESGQLETALDETIDMYGAKSVIAWDDRRFHEFGLGSFLTRPSVSLWDNRDSKRSIEQAEIADVGITFSDITLAESGTVTLFSSNGKGRSVSLLPRYYIAIIPKSTLVARMTQAARHIRQLTGEGRLPSCINFISGPSNSADIEMSLVVGVHGPLKACYIVVDDK
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
What are the official names of this protein?
Lactate utilization protein C.
What is the protein family that this protein belongs to?
Belongs to the LutC/YkgG family.
Protein: EXG1_ARTBC
Sequence: MKFGSLLGLSLVGLSVASPVTNVWKSPRAADDFIRGVNLGGWLVLEPWITPGIFEEGGDSAVDEWTLSAALGHRAHERLKLHWNTFMEQKDFDRIKGAGLTHVRIPIGYWAVAPIQGEPFVQGQVDMLDAAIDWARHSGLKVNVDLHGAPGSQNGFDNSGRLGPANWQKGDTVAQTYKALDVLIQRYAKKDGVVDEINLINEPFPQAGIQVEPLKDYYRQGAAKVKSANPNVAVVISDAFMGPSKWNGFDVGAKTIIDTHHYQVFSPQLVAMDINQHVKAACDFGNDELAKSSIPAIVGEWCGALTDCTQYLNGRHEGARYDGTHKDSDPKTAVPNGCVRKTGGSASQLTDEEKTNTRRYIEAQLDSFSKGHGWFWWTWKTERGSPGWDLNDLLSNGLFPQPLDSRMFLGQCN
What is the function of this protein?
Major glucan 1,3-beta-glucosidase required for cell wall integrity (By similarity).  Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall (By similarity).  Can also function biosynthetically as a transglycosylase (By similarity).  Functions to deliver glucan from the cell to the extracellular matrix (By similarity).  Involved in cell-substrate and cell-cell adhesion (By similarity).
What are the official names of this protein?
Probable glucan 1,3-beta-glucosidase ARB_04467, Exo-1,3-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall. Note=Is non-covalently attached to the cell wall.
Protein: RL28_SALG2
Sequence: MSRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRVSAKGMRIIDKKGIETVLSELRARGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: NNRE_DROSE
Sequence: MDLKYLNQKEAIAVDQELFNEYKFSVDQLMELAGLSCAHAVAKCFPAEKHPRILVCCGPGNNGGDGLVAARHLALMGYTPTIYYPKPTAKPLFENLSHQCQQMDICDVKECPSVESAARDYDLILDALFGFSFKPPVRADFVAVVELMQQTKLPIASVDIPSGWDVEKGKLTECDVEPALLISLTAPKLCARQFRGEHHYLGGRFVPPALQRKYELNLPVYPGNELCVKL
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
Protein: CRIM1_DANRE
Sequence: MASSRMYLLVKCMLILQLMVLIAKNSRALICLPCDKSKCEEPKPCTGSVVLGICGCCSVCAKQKNESCGGVYGLYGTCDRGLRCVIRPPLNGGSITQYEVGNCEDENWDDDQLLGFEPCNENLVTGCNIIDGKCECDSVRTCNNPFEFASQEACQTALQKIEEERPDCSKARCEVQFSPRCPEDSILIEGYAPPGECCPLPSRCVCSPAGCLRKVCQPGHLNILVSKSSGKPGECCDLYECKPVFSVDCSTVECPPVKPVQCPADSYETQVRLTADGCCTLPTRCECLPGLCTFPQCSAGMSPQVMSRGDGTPGRCCDVFECVNETKPACTLNGVEYHDGDMFRMDACRFCRCQGGVSVCFTAQCGVLHCERYYVPDGECCPVCEDPIYPVLSLAGCYVNGQILAHGDHWREDDCTFCQCVSGDARCVAAACGHSCLNPVTVPGECCPVCEEPTYITMAPPACGSLDNCTLLEQSCAFGFRLDPSGCRTCACKSREELCGGLMASCTLKCPFGFQTDIHGCDVCQCRPRHKKCKAVACAKDCPFGYIKNKHGCDTCRCKKCPELPCDKACPMGFQHDELGCLICQCRDQSSSSVTPAVKLGSCLSMDGRRHENGQSWHDGCRDCYCHAGREMCALISCPVPPCDNPTIRPGHCCPTCPEESSSHKPELSEASVCLAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCHSPIRTQDSCCPHCPDDPVTPQTPSNDSMPSYCRNEDGDIFLAAESWKPNVCSSCVCLDGAISCFSESCPPVNCARPVLRKGQCCPYCLDATPRAVCHFNGKTYMDEERWDIDSCTHCYCLQGQTLCSTVSCPALPCHQPLTVEGSCCPMCPESYAPTNVPIEKTDQRGDKSRHQPAWPTHSENDVMPQFRGEFGSLQMPYLDGKTPLPSEDAGLHWAWVALPVLMMMLTLAALLLVNQRKQWIPVPCYRTPNKSTCLNNQLVYVDCQKGTKVQVDSSQRMLRIADPDSRYSGYYSMQKHNNLQADNFYQTA
What is the function of this protein?
May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.
What are the official names of this protein?
Cysteine-rich motor neuron 1 protein, CRIM-1.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PYRE_MYCA1
Sequence: MAEPELEELAELVRRLSVVHGRVTLSSGKEADYYVDLRRATLHHRASALIGRLMRELTSDWDYAVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKTHGLQRLIEGSEVAGKRVLVVEDTSTTGNSALTAVRAVQQAGGQVLGVATVVDRATGAAEAIEAEGLPYRSVLGLADLGLG
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: Y1620_SHEPW
Sequence: MKFLVDTHAHTIASTHAYSTLHDYLNVAKEKGIKLFAITDHGPDMADAPHFWHFVNMRVLPRIIDGVGVLRGIEANIKNQQGDIDFFGDYLKQLDIVLAGFHEPVFPPSTAENHTQALINCIESGKVDIISHPGNPAYPIDIERVAQAAAKHNVALEINNSSFLTSRKGSEKSCRAIALAVKEAGGLLVMGSDSHVAFSLGDFDKAVEVIEAVQFPIERLLNRSPEALLCFLSARGHDSLDEYADLV
What are the official names of this protein?
Probable phosphatase swp_1620.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: MINY3_HUMAN
Sequence: MSELTKELMELVWGTKSSPGLSDTIFCRWTQGFVFSESEGSALEQFEGGPCAVIAPVQAFLLKKLLFSSEKSSWRDCSEEEQKELLCHTLCDILESACCDHSGSYCLVSWLRGKTTEETASISGSPAESSCQVEHSSALAVEELGFERFHALIQKRSFRSLPELKDAVLDQYSMWGNKFGVLLFLYSVLLTKGIENIKNEIEDASEPLIDPVYGHGSQSLINLLLTGHAVSNVWDGDRECSGMKLLGIHEQAAVGFLTLMEALRYCKVGSYLKSPKFPIWIVGSETHLTVFFAKDMALVAPEAPSEQARRVFQTYDPEDNGFIPDSLLEDVMKALDLVSDPEYINLMKNKLDPEGLGIILLGPFLQEFFPDQGSSGPESFTVYHYNGLKQSNYNEKVMYVEGTAVVMGFEDPMLQTDDTPIKRCLQTKWPYIELLWTTDRSPSLN
What is the function of this protein?
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase MINDY-3, Dermal papilla-derived protein 5, Deubiquitinating enzyme MINDY-3, Protein CARP.
What is the protein family that this protein belongs to?
Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: VN1R3_HUMAN
Sequence: MASKDFAIGMILLSQIMVGFLGNFFLLYHYSFLCFTRGMLQSTDLILKHLTIANSLVILSKGIPQTMAAFGLKDSLSDIGCKFVFYVHRVGRAVCVGNACLLSVFQVITISPSEFRWAELKLHAHKYIRSFILVLCWILNTLVNITVLLHVTGKWNSINSTKTNDYGYCSGGSRSRIPHSLHIVLLSSLDVLCLGLMTLASGSMVFILHRHKQQVQHIHGTNLSARSSPESRVTQSILVLVSTLCYFTRSPPSLHMSLFPNPSWWLLNTSALITACFPMVSPFVLMSRHPRIPRLGSACCGRNPQFPKLVR
What is the function of this protein?
Putative pheromone receptor.
What are the official names of this protein?
Vomeronasal type-1 receptor 3, V1r-like receptor 3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MET3_MUCCL
Sequence: MANTPHGGVLKDLYLRDAGKQESLAAEAATLPSVVLTDRQLCDLELLLNGGFSPLEGFLNQKDYEGVVENMRLANGLLWTIPITLDVSKEQIEESKIEPSKRIALLDPRDYEPLAILTVEDVYRPDKSKEAALVYGADDSAHPAVHYLHNIAKEFNVGGSLEAVQSPSHYDYVANRYTPTELRAHFKKLQWTRVVAFQTRNPMHRAHRELTVRAARQRKAHLLIHPVVGLTKPGDIDHYTRVRVYKALMPKYPNGMAELSLLPLAMRMGGPREAVWHALIRKNHGVTHFIVGRDHAGPGKNSQGVDFYGPYEAQELVEKYKSEIGIEIVPFQMVTYSPDTDEYIPADEVPEGVKTLNISGTELRRRLKTGLPIPEWFSYPEVVSVLRQSHPPRNQQGFTIFFTGLHASGKNAIARALQVSLNQESTRSVSLLASENTRAELSSELGFSKRDRDINIARQAFVAGELTRAGAAAIVAPIAPYAEARNAAKKTIEQFGGFYLVHVATPLEECIKRDRDGIYERAKRGEIKEFTGLDAPYEVPTNADLTIDITQQSVSQAVHEIILLLEKDGYIGSA
What is the function of this protein?
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP.  Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the APS kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNK_SERP5
Sequence: MSHYRTFTAADAVEYARQYGQLADPQALVSADEIGDGNLNLVFKIRDRDGVSRVIVKQALPYVRCVGESWPLTLDRARIEAETLLIHGGFCPRHTVKVLHHDAELAVMVQEDLSDHHIWRSELVKGHYYPLAAGQLAEYLAQTLFHTSDFYQTAQEKKAEVSRFSNPELCQITEDLFFTDPYIDHERNQFDPALLPQVLELRNDAALRLAVAGLKHRFLSKAEALLHGDIHSGSVFVAEGKLKAIDAEFGFYGPIGFDVGTALGNLLLNYCGLPGLFGPRDAAAGREQRLQDVRELWLIFADRFLALCHQQTREAALAVPGYAEQFLQQVWTDAVGYCGSELIRRTIGLAHVADLDSISDAEMRAECQRNALGLGRALIVNAPQIEHIDALLARIRQNG
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
What are the official names of this protein?
Methylthioribose kinase, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: SYS_EHRRW
Sequence: MHDIDFIKNNPELFDEAMQNRNFGKIAHKIIELSANKKHTLTQLYSLQKERNNITQEIEKLKKDNIQCDTQIELSKEITKKINHINNMIKTDSELIDLLNILPNIPDKKVPIGKDENDNIEIRRYGKKVDFKFPPKTHYELGENLNLMDFKQAAKLSGSRFVILKSQLAQLDRALANFMLDVHTQEFGYSEISHPVLVHESAMYGVGQLPKFADDSFKTTDNFRLIPTSEVALTNLVSNTNTNANELPIRLTACSQCFRSEAGSAGKDVRGMMRQHQFNKVELVSIVTEEQSELELERMTQVAEEILKKLELPYRVMMLCTGDLGFSASITYDIEVWIPSQNQYREISSCSNCKAFQARRMNAKYHTISNGNKVNKFVHTLNGSALAIGRTIIAILENYQNQDGSITIPHVLRKYMNNQDIIKNNNY
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_ASHGO
Sequence: MSTKSYAERAKAHNSPVARKLLALMHEKKTNLCASLDVRTSRKLLELADTLGPHICLLKTHVDILTDFDIETTVKPLQQLAAKHNFMIFEDRKFADIGNTVKLQYSSGVYRIAEWADITNAHGVTGPGVIAGLKEAAKLASQEPRGLLMLAELSSQGSLARGDYTAGVVEMAKLDKDFVIGFIAQRDMGGRADGFDWLIMTPGVGLDDKGDGLGQQYRTVDEVVSDGTDVIIVGRGLFDKGRDPNVEGARYRKAGWEAYLRRIGETS
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase, Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family.
Protein: TGT_PSEPK
Sequence: MSFELLATDGKARRGRITFPRGTVETPAFMPVGTYGTVKGMLPRDIEAIGAEMILGNTFHLWLRPGTEVIKKHNGLHDFMQWKGPILTDSGGFQVFSLGAMRKIKEEGVTFASPVDGSKVFMGPEESMQVQRDLGSDVVMIFDECTPYPAEHDVARTSMELSLRWAQRSKNAHADNTAALFGIVQGGMYQDLRMRSLEGLENIGFDGLAIGGLSVGEPKHEMIKVLDYLPDQMPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFVDTGVIKIRNAFHRHDESPLDPTCDCYTCTNFSRAYLHHLDKCGEMLSSMLNTIHNLRHYQRLMAGLREAIQQGKLAAFVDAFYAKRGLPVPPLD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: JZTX3_CHIGU
Sequence: MKNTSILFILGLALLLVLAFEAQVGESDGECGGFWWKCGRGKPPCCKGYACSKTWGWCAVEAP
What is the function of this protein?
Selectively inhibits activation of voltage-gated sodium channels (VGSC) (Nav1. 5/SCN5A) in rat cardiac myocytes, followed by shifting activated voltage in a depolarizing direction.  The binding site on VGSC is suggested to be site 4 located at the extracellular S3-S4 loop of the channel.  Also binds to voltage-gated potassium channels (Kv2. 1/KCNB1).
What are the official names of this protein?
Beta/kappa-theraphotoxin-Cg1a, Beta/kappa-TRTX-Cg1a, Jingzhaotoxin-3, Jingzhaotoxin-III, JZTX-III, Peptide F5-20.38.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 44 (Jztx-4) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ALBU_HORSE
Sequence: MKWVTFVSLLFLFSSAYSRGVLRRDTHKSEIAHRFNDLGEKHFKGLVLVAFSQYLQQCPFEDHVKLVNEVTEFAKKCAADESAENCDKSLHTLFGDKLCTVATLRATYGELADCCEKQEPERNECFLTHKDDHPNLPKLKPEPDAQCAAFQEDPDKFLGKYLYEVARRHPYFYGPELLFHAEEYKADFTECCPADDKLACLIPKLDALKERILLSSAKERLKCSSFQNFGERAVKAWSVARLSQKFPKADFAEVSKIVTDLTKVHKECCHGDLLECADDRADLAKYICEHQDSISGKLKACCDKPLLQKSHCIAEVKEDDLPSDLPALAADFAEDKEICKHYKDAKDVFLGTFLYEYSRRHPDYSVSLLLRIAKTYEATLEKCCAEADPPACYRTVFDQFTPLVEEPKSLVKKNCDLFEEVGEYDFQNALIVRYTKKAPQVSTPTLVEIGRTLGKVGSRCCKLPESERLPCSENHLALALNRLCVLHEKTPVSEKITKCCTDSLAERRPCFSALELDEGYVPKEFKAETFTFHADICTLPEDEKQIKKQSALAELVKHKPKATKEQLKTVLGNFSAFVAKCCGREDKEACFAEEGPKLVASSQLALA
What is the function of this protein?
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs.  Its main function is the regulation of the colloidal osmotic pressure of blood.  Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity).  Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).  Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity).  The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (By similarity).  The rank order of affinity is zinc > calcium > magnesium (By similarity).  Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E. coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E. coli (By similarity).  Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
What are the official names of this protein?
Albumin.
What is the protein family that this protein belongs to?
Belongs to the ALB/AFP/VDB family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS4_BURL3
Sequence: MARYIGPKAKLSRREGTDLFLKSARRSLADKCKLDSKPGQHGRTSGARTSDYGTQLREKQKVKRIYGVLERQFRRYFAEADRRKGNTGENLLQLLESRLDNVVYRMGFGSTRAEARQLVSHKSITVNGVVANVPSQQVKSGDVVAIREKAKKQARIVEALSLAEQGGMPSWVAVDAKKFEGTFKQMPERAEIAGDINESLIVELYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: CCKN_PAROL
Sequence: MTAGLCVCVLLAVLCTSCLGHPISSQHLDEGQRSISTPSEALLEADTHSLGEPHLRQSRSAPQLKSLPVAEEDGDSRANLSELLARLISSRKGSVRRNSTAYSKGLSPNHRIADRDYLGWMDFGRRSAEEYEYSS
What is the function of this protein?
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut.  Its function in the brain is not clear (By similarity).
What are the official names of this protein?
Cholecystokinin, CCK.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: BAG2_HUMAN
Sequence: MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEILLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRNPQQQESLKHATRIIDEVVNKFLDDLGNAKSHLMSLYSACSSEVPHGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIENSDKAIKLLEHSKGAGSKTLQQNAESRFN
What is the function of this protein?
Co-chaperone for HSP70 and HSC70 chaperone proteins.  Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).
What are the official names of this protein?
BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2.
Protein: SPEB_ECO5E
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHNRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLAAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPNHSVQIGIRTEFDKDNGFTVLDACQVNDRSVDDVIAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: RPIA_PSEE4
Sequence: MTQDQLKQAVAQAAVDLILPKLDEKSVVGVGTGSTANFFIDALAQHKTAFDGAVASSEATAQRLKGHGIPVYELNSVSELEFYVDGADESDAHLNLIKGGGAALTREKIVAAVAKTFICIADASKLVPVLGAFPLPVEVIPMARSHVARQLVKLGGDPVYREGVVTDNGNVILDVHNLQITNPVELESQINAIVGVVTNGLFAARPADVLLLGTAEGVKTLKAE
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: XRN2_NEUCR
Sequence: MGIPAAFRWLSTKYPKIISPVIEDQPITMPDGTVIPVDATKPNPNGEEFDNLYLDMNGIVHPCSHPEDRPAPKDEEEMMVEVFKYTDRVVNMVRPRKLLMIAVDGVAPRAKMNQQRSRRFRAAREAMEKEEDKQKFVELLKKQNGKPQEEEPVEVVVKKAFDSNSITPGTPFMDILAASLRYWCSYKLNTDPAWANIKVIISDATVPGEGEHKIMEFVRSQRGSPNHDPNTRHVIYGLDADLIMLGLATHEPHFRVLREDVFAQDSRPRLCKICGQKGHDAMNCKGEAKEKNGEFDEKDAVVPLKPFIWLHVSILREYLAIELDVPGLPFQFNLERAIDDWVFMCFFVGNDFLPHLPALEIRENGIDTLTAIWKDNLPVMGGYLTKDGHADLERVQYIMAGLAKQEDAIFRRRKETEDRREAGFKRRKLADEARQRRAQGSRQIRQAAENSGPPAGFSFHKINEFPGKAPQPSITHDMVVNRQAVDQANVANKSAASVLKDQIKSMMAQGTSTPENGAESTETPAETAAAAPATEEQAAPPAALGKRKAELIEDAVAGPEASSTEVTEISESDAEPTDSVRLWEEGYADRYYEQKFKVDRKDIDFRHKVGRAYAEGLAWVLEYYFQGCPSWEWFYPYHYAPFAADFVDLGKMEIKFEKGRISRPFEQLMSVLPAASRHAIPEVFHSLMLEETSEIRHFYPDDFEIDLNGKKMAWQGVALLPFIDMPRLLAAMETKSHLLSPEDHLRNAPGKDYLLLSDSHPTLYDHITSQFYSKKQGTTKFELDPTKSAGLSGLVEKIDGYVPHGSLVYPLSRNSMPDVDYDRSLMVHYFFPDCSHTHKSMLLRGVQMPTPALTRSDIDILKGKASRSGRSYGGVPLSNKNYSGRNEPINYGPGGGQQGGRGRGGYQGGGGRGGGRGGYGGNGGGYQANGGGYYNGGNNGGGGGGYGGQPRDSYGPPPGWQPPPPPGLAGFGVGPPPPPPGAAYGGAPGGAGYGGYGSSRGGYQDNRYALPPPPPQAYQAQGQQYGQGGSRGGYQGQGNQYRGPPRQDRGYDNRGGYRGGGYRGGGDNRGYR
What is the function of this protein?
Possesses 5'->3' exoribonuclease activity.  Required for the processing of nuclear mRNA and rRNA precursors.  May promote termination of transcription by RNA polymerase II (By similarity).
What are the official names of this protein?
5'-3' exoribonuclease 2, Exoribonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PNXAA_SCOSU
Sequence: MTVSCSKVLLSLCLFLMLLKATHESNQQRTNFREFFEIQLAQETREINEKNNQPLNQQLPQLNRRKRLWRDEDRRTFCTTLCPCEDRRKRAAVTPPTRKVPCCCP
What are the official names of this protein?
Putative neurotoxin 10.
What is the protein family that this protein belongs to?
Belongs to the scolopendra neurotoxin 10 family.
What are the subcellular locations of this protein?
Secreted.