PharMolix/UniProtQA huggingface dataset:
Protein: NLRP3_MOUSE
Sequence: MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQMEKADHLDLATLMIDFNGEEKAWAMAVWIFAAINRRDLWEKAKKDQPEWNDTCTSHSSMVCQEDSLEEEWMGLLGYLSRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGESVDLNSRYTQLQLVKEHPSKQEREHELLTIGRTKMRDSPMSSLKLELLFEPEDGHSEPVHTVVFQGAAGIGKTILARKIMLDWALGKLFKDKFDYLFFIHCREVSLRTPRSLADLIVSCWPDPNPPVCKILRKPSRILFLMDGFDELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEVLFTMCFIPLVCWIVCTGLKQQMETGKSLAQTSKTTTAVYVFFLSSLLQSRGGIEEHLFSDYLQGLCSLAADGIWNQKILFEECDLRKHGLQKTDVSAFLRMNVFQKEVDCERFYSFSHMTFQEFFAAMYYLLEEEAEGETVRKGPGGCSDLLNRDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQVRLELLKWIEVKAKAKKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFPKIEINLSTRMDHVVSSFCIKNCHRVKTLSLGFFHNSPKEEEEERRGGRPLDQVQCVFPDTHVACSSRLVNCCLTSSFCRGLFSSLSTNRSLTELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLSHQCCFDISSVLSSSQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSACCQDLALVLSSNHSLTRLYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSALTSVLKTNQNFTHLYLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLSTILTHNHSLRKLNLGNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQEEKPELTIVFEISW
What is the function of this protein?
Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (PubMed:26098997).  During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (PubMed:26098997).  Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (PubMed:26098997).  May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (PubMed:26098997).
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 3, Cold autoinflammatory syndrome 1 protein homolog, Cryopyrin, Mast cell maturation-associated-inducible protein 1, PYRIN-containing APAF1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Inflammasome. Endoplasmic reticulum. Secreted. Nucleus. Note=In macrophages, under resting conditions, mainly located in the cytosol, on the endoplasmic reticulum. After stimulation with inducers of the NLRP3 inflammasome, mitochondria redistribute in the vicinity of the endoplasmic reticulum in the perinuclear region, which results in colocalization of NLRP3 on the endoplasmic reticulum and PYCARD on mitochondria, allowing the activation of inflammasome assembly (PubMed:23502856). After the induction of pyroptosis, inflammasome specks are released into the extracellular space where they can further promote IL1B processing and where they can be engulfed by macrophages. Phagocytosis induces lysosomal damage and inflammasome activation in the recipient cells (PubMed:24952505)(PubMed:24952504). In the Th2 subset of CD4(+) helper T-cells, mainly located in the nucleus. Nuclear localization depends upon KPNA2 (PubMed:26098997). In the Th1 subset of CD4(+) helper T- cells, mainly cytoplasmic (PubMed:26098997).
Protein: SYGB_LACLM
Sequence: MTNYLLEIGLEEIPAHLVTPSINQLAERMEAFLNENRLKFDKIIKFSTPRRLALIVEELSDSSEAIDEEVKGPSAKIAKDAEGNWSKAIQGFSRGQGATPDDLILKGDYYYAKKHVDGVKSEEILSKVGDEVIAKMTFSTYMKWGNNDFLFVRPIQWIVSLLEDEIVAFDLLDVTANRFSRGHRFLANVEIELKNANDYASKMPENFVLVDAEHRKAEISAQILALASENNWQVTLHKDLLEEVNNIVEYPTAFVGSFDPKYLSVPAEVLVTSMRDNQRYFEVYNQEGQLAPNFISVRNGNAEHIENVVLGNEKVLFARLEDAEFFWKEDQKLKIEDLVAKLAKVTFHAKIGSITEHMARTKLIAAKLADIAGLTDEEKVDVARSAEIYKFDLLTGMVGEFDELQGVMGEKYALLAGENANVAAAIREHYMPTSADGQLPETKVGSVLAAADKIDSVLSFFNVGLIPSGSNDPYALRRAVQGLIRIIEKMNWHFDLSLFIDQFEGQNHAEILEFVKARVQKLLLEKLDRYDIVEAAINSSNFDITNMMESAFVIDGHKLHEPFKPAIENVSRSINLVKKAADIAEINPALFEEDTEQALYDAVISLQNQWTYKPCEEKFRAIVHMLAPAIEAFFDNVMVMAEDLAVRDNRIALLSEVVALTSVMADFSLINTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPK4_AUSRA
Sequence: SGGGEGSGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
CAPA-Pyrokinin, CAPA-PK, FXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP6_MYCTU
Sequence: MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAFYLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIGMRIAPFVLPLAVTIFVFILISNWLAVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKLLKGHVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLFVGAIQAFIFALLTILYFSQAMELEEEHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CRP1_ORYSJ
Sequence: MPASSLLPPTLLPHRHRLRLPPAGCSTSSSPSATRYDFDPLLSYLSTTSSSPSPPPTSVLPVTESRLAASYAAVPAREWHALLRELAATDASLPLAFALLPFLHRHRLCFPLDLLLSSLLHSLSVSGRLLPHSLLLSFPPSLSDPPSPLLLNSLLAASAAASRPAVALRLLGLLREHSFLPDLASYSHLLASLLNTRDPPDAALLDRLLGDLRESRLEPDAPLFSDLISAFARARLPDAALELLASAQAIGLTPRSNAVTALISSLGSARRVAEAEALFLEFFLAGEIKPRTRAYNALLKGYVKIGSLKNAEQVLDEMSQCGVAPDEATYSLLVDAYTRAGRWESARILLKEMEADGVKPSSYVFSRILAGFRDRGEWQKAFAVLREMHASGVRPDRHFYNVMIDTFGKYNCLGHAMDAFDRMREEGIEPDVVTWNTLIDAHCKGGRHDRAIELFDEMRESNCPLGTTTYNIMINLLGEEQRWEGVEAMLAEMKEQGLVPNIITYTTLVDVYGRSGRFKEAVDCIEAMKADGLKPSPTMYHALVNAYAQRGLADHALNVVKAMRADGLEASTVVLNSLINAFGEDRRIAEAFSVLQFMKENGLRPDVITYTTLMKALIRVEQFEKVPVIYEEMITSGCAPDRKARAMLRSALRYMKHMRVA
What is the function of this protein?
Required for the processing and translation of chloroplast mRNAs.
What are the official names of this protein?
Pentatricopeptide repeat-containing protein CRP1 homolog, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IOLC_MESH7
Sequence: MKKEFDFILIGRITIDFNPTDYYNNLENSSLFKKYIGGSAANIAIGLSRLKNKVGFFGSVSDDQFGNFVLNVFENEKIDISHIKKTKDHKLGLTFTEMLSEEKSTILMYRDNVADLQIDVSDIDLDYILRTKILVISGTSLAKSPSREAVLKALFLAKNNGIKVVFDIDYRPYSWKNLDEVSLYYQIVAQNSDLIIGSYEEIQLTSRFCLENPENLIDDDYAKYWLKFVDLIIIKNGKKGSKLYQKDKKLVAKIVPVKMLKGYGGGDAYASLFLDHYLKNESDLENGLALATSAASIMVQSHSSFDLPDYQKILEFKDNALKSDPDLVQKKEWNAFKK
What is the function of this protein?
Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).
What are the official names of this protein?
5-dehydro-2-deoxygluconokinase, 2-deoxy-5-keto-D-gluconate kinase, DKG kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: MERP_SHIFL
Sequence: MKKLFASLALAAAVAPVWAATQTVTLAVPGMTCAACPITVKKALSKVEGVSKVDVGFEKREAVVTFDDTKASVQKLTKATADAGYPSSVKQ
What is the function of this protein?
Involved in mercury resistance (PubMed:1328156).  Acts as a mercury scavenger that specifically binds to a mercuric ion in the periplasm and probably passes it to the cytoplasmic mercuric reductase MerA via the mercuric transport protein MerT (PubMed:9368013, PubMed:9649312).
What are the official names of this protein?
Mercuric transport protein periplasmic component, Mercury scavenger protein, Periplasmic mercury ion-binding protein.
What is the protein family that this protein belongs to?
Belongs to the MerP family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MNMA_MESH7
Sequence: MAKIVVGLSGGVDSAVSAYLLKKAGHNVIAVFMRNWDSSLNNDFLGKKNEKNFTICPQEQDWLDAKVVAKQLNIPIFRIDFIKEYWDEVFSDLILKYQSGLTPNPDILCNKNIKFKHFLDYAQKVHNADFIAMGHYAKTDNGNLYAGADSLKDQSYFLGQLSKSQLQKTIFPLGNLLKSEVRKIANELGLINAKKKDSTGICFIGERKFTDFLQNYIPAQPGNIIDISTKKVLGKHIGIMYFTIGQRKGFGLSGMKEPYFVVGHNLKEKILYVSPQSEKKWLESDSLMAKNANFLSENFRNLDNLSAKFRYRQEAIPIRIEKIQDNSFWISYQKYQAITPGQQVVIYHQNQVILAGEIALLFRNGKKLDYLD
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_SALG2
Sequence: MSNIIKQLEQEQMKQNVPSFRPGDTVEVKVWVVEGTKKRLQAFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVVDSIAVKRRGAVRKAKLYYLRERTGKAARIKERLN
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: UPPP_BURMS
Sequence: MDWILICKALALGIVEGLTEFLPVSSTGHLIVAGSFLRFHPEQAKTFDVVIQFGAILAVCWEYRRRIIDVVTGLPAQREARRFTMNVVIATVPAVALALLFEKTIKSVLFAPVPVAVALVVGGAAILWVEGRQRERSEPARVQSIDALTPFDALKVGLAQCCALIPGMSRSGSTIIGGMLFGLERRVATEFSFFLAIPVIFGATLYETAKDWRAFNVDSVGLFAIGLVAAFVSAFACVRWLLRYVASHDFTAFAWYRIAFGLFVLLVGYSGWIEWT
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: JANA_DROYA
Sequence: MNRLQLFSKGLRLIHKMSEEALAGVPLVHISPEGIFKYVLINVIDGGDASKAVVRGFDDCTWHADIFDREEEVFKKLGLRAECPGGGRIEHNPEKKYLKVYGYSQGFGKADHAQTKRILATKYPDYTIETSDEGY
What is the function of this protein?
JanA and janB regulate somatic sex differentiation.
What are the official names of this protein?
Sex-regulated protein janus-A.
What is the protein family that this protein belongs to?
Belongs to the janus family.
Protein: ABHD8_BOVIN
Sequence: MLTGVTDGIFCCLLGAPPNAVGPLESVESSDGYTFVEVKPGRVLRVKHAGPAPAPTPPPPLSDAAQGDQSGLVRCQRRITVYRNGRLLVENLGRAPRADLLHGQNGSGEPPAALEVELADPAGSDGRSVPGSAGSGSGGRRRRARRPKRTIHIDCEKRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSLCSVFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMVMLECPETVNTLLHEFLLWEPEPSPKALPEPLPAPPEEKK
What are the official names of this protein?
Protein ABHD8, Alpha/beta hydrolase domain-containing protein 8, Abhydrolase domain-containing protein 8.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: LTND_PECAS
Sequence: MKKTSDYAVAVIGLGSMGFGAAASCINAGLTTYGVDINPQALEKLRQAGAAQADTRIDAFADKLDAVVLLVVNATQVNGILFGEPQVAAKLKPGTVVMVSSTISAQDAKNIEQRLAEHQLVMLDAPVSGGAAKAAAGDMTVMASGSDLAFEKLKPVLDAVAGKVYRIGEEIGLGATVKIIHQLLAGVHIAAGAEAMALAARADIPLDIMYDVVTNAAGNSWMFENRMRHVVDGDYTPKSAVDIFVKDLGLVTDTAKSLHFPLPLASTAFNMFTAASNAGFGKEDDSAVIKIFNGITLPEKKEAP
What is the function of this protein?
Catalyzes oxidation of L-threonate to 2-oxo-tetronate.  Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+).
What are the official names of this protein?
L-threonate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the HIBADH-related family. L-threonate dehydrogenase subfamily.
Protein: XERC_ECO81
Sequence: MTDLHTDVERYLRYLSVERQLSPITLLNYQRQLEAIINFASENGLQSWQQCDVTMVRNFAVRSRRKGLGAASLALRLSALRSFFDWLVSQNELKANPAKGVSAPKAPRHLPKNIDVDDMNRLLDIDINDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLESGEVWVMGKGSKERRLPIGRNAVAWIEHWLDLRDLFGSEDDALFLSKLGKRISARNVQKRFAEWGIKQGLNNHVHPHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates.  The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.  In the complex XerC specifically exchanges the top DNA strands.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_HBVC8
Sequence: MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTAAALYREALESPEHCSPHHTALRQAILCWVELMTLATWVGNNLEDPASRDLVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIGTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
What is the function of this protein?
Self assembles to form an icosahedral capsid.  Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins.  Entering capsids are transported along microtubules to the nucleus.  Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta.  Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153.  Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm.  Immature capsids get stuck in the basket.  Capsids encapsulate the pre-genomic RNA and the P protein.  Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm.  The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.
What are the official names of this protein?
Capsid protein, Core antigen, Core protein, HBcAg, p21.5.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus core antigen family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: RS19_CORGB
Sequence: MPRSLKKGPFVDEHLLNKVDAQNEKGTKQVIKTWSRRSTILPDFIGHTFAVHDGRKHVPVFVDDAMVGHKLGEFAPTKTFKGHVKDDKKGRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: PTNB_XENLA
Sequence: MHHQHGLFMLALLAFLLVMTVLGTDTGKKDKQEKKVKKSDCGDWQWSVCVPTSGDCGLGTREGTRSGKECKQTIKTQKCKIPCNWKKQFGAECKYQFQEWGDCDPETGLKTRNGNLKRALHNAECQKTVTLSKPCGKVTKPKLQESKKKKKEGKNKEKLLD
What is the function of this protein?
Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity).  Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity).  Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity).  Has antibacterial activity against both Gram-positive and Gram-negative bacteria (PubMed:20308059).
What are the official names of this protein?
Pleiotrophin-B, PTN-B, Pleiotrophic factor-beta-2, PTF-beta-2, X-PTF-beta2.
What is the protein family that this protein belongs to?
Belongs to the pleiotrophin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS7_MESM1
Sequence: MSRRKKAPIRQVLSDPIFNSKTITKLINTIMLDGKKSIAERILYQAFEIIKTKTNKDPMEVFQLALDNITPQLEVKTRRVGGTNYQVPMEVTKRRKETLSLRWLIHYSRLRSEKTMQECLANEIIDASNKTGSSIKKREDTHKMAEANKAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: 1A_BMV
Sequence: MSSSIDLLKLIAEKGADSQSAQDIVDNQVAQQLSAQIEYAKRSKKINVRNKLSIEEADAFRDRYGGAFDLNLTQQYHAPHSLAGALRVAEHYDCLDSFPPEDPVIDFGGSWWHHFSRRDKRVHSCCPVLGVRDAARHEERMCRMRKILQESDDFDEVPNFCLNRAQDCDVQADWAICIHGGYDMGFQGLCDAMHSHGVRVLRGTVMFDGAMLFDREGFLPLLKCHWQRDGSGADEVIKFDFENESTLSYIHGWQDLGSFFTESVHCIDGTTYLLEREMLKCNIMTYKIIATNLRCPRETLRHCVWFEDISKYVGVSIPEDWSLNRWKCVRVAKTTVREVEEIAFRCFKESKEWTENMKAVASILSAKSSTVIINGQAIMAGERLDIEDYHLVAFALTLNLYQKYEKLTALRDGMEWKGWCHHFKTRFWWGGDSSRAKVGWLRTLASRFPLLRLDSYADSFKFLTRLSNVEEFEQDSVPISRLRTFWTEEDLFDRLEHEVQTAKTKRSKKKAKVPPAAEIPQEEFHDAPESSSPESVSDDVKPVTDVVPDAEVSVEVPTDPRGISRHGAMKEFVRYCKRLHNNSESNLRHLWDISGGRGSEIANKSIFETYHRIDDMVNVHLANGNWLYPKKYDYTVGYNEHGLGPKHADETYIVDKTCACSNLRDIAEASAKVSVPTCDISMVDGVAGCGKTTAIKDAFRMGEDLIVTANRKSAEDVRMALFPDTYNSKVALDVVRTADSAIMHGVPSCHRLLVDEAGLLHYGQLLVVAALSKCSQVLAFGDTEQISFKSRDAGFKLLHGNLQYDRRDVVHKTYRCPQDVIAAVNLLKRKCGNRDTKYQSWTSESKVSRSLTKRRITSGLQVTIDPNRTYLTMTQADKAALQTRAKDFPVSKDWIDGHIKTVHEAQGISVDNVTLVRLKSTKCDLFKHEEYCLVALTRHKKSFEYCFNGELAGDLIFNCVK
What is the function of this protein?
Involved in the virus replication.  Contains a helicase domain and a methyltransferase domain.  The methyltransferase domain is probably involved in viral RNA capping.  Involved in the formation of ER membrane spherular invaginations in which RNA replication complexes form.
What are the official names of this protein?
Replication protein 1a.
What is the protein family that this protein belongs to?
Belongs to the bromoviridae replication protein 1a family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: TCIM_HUMAN
Sequence: MKAKRSHQAVIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAIDQDVEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH
What is the function of this protein?
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type.  May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711).  Enhances the proliferation of follicular dendritic cells (PubMed:16730711).  Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821).  In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084).  Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013).  Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity).  In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347).  However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).
What are the official names of this protein?
Transcriptional and immune response regulator, Thyroid cancer protein 1, TC-1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus speckle. Nucleus. Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013).
Protein: UVRC_BEUC1
Sequence: MADPTTYRPRPGEIPDAPGVYRFRDPHGRVVYVGKAKSLRSRLSSYFQDLSALHPRTQQMVTTASSVEWTVVGTEVEALQLEYSWIKEFDPRFNVKYRDDKSYPYLAVTMGEEVPRVQVMRGAKRKGTRYFGPYGHAWAIRETVDLLLRVFPVRTCSSGVYKRAAASGRPCLLGYIDKCSAPCVGRISVEDHRDLAEDFCSFMAGESGVFLRRLESEMAAASAELDFERAARVRDDINALRRVVEKNAVVLADGTDADVFALAADELEVSVQVFHVRGGRVRGQRGWVTERVEDLDDGALVERLLQQVYGPYATEKGPDGGATGVPREVLVPALPDDAVELAEWLSTLRGSRVSLRIPQRGEKRALAETVRTNAQQALALHKTRRAGDLTSRSRALSELQEELGLAESPLRIECYDISTLQGTHQVGSMVVFEDGLARKSEYRQFVVRGADGQGARDDTEAMHEVITRRFRRYLAQRDVGVAGGGSGEVPAEDDDGVAIAGPVDPETGRPARFAYPPNLVVVDGGPPQVAAAQRALDELGVSDVALVGLAKRLEEVWLPGEEYPLVLPRASEGLYLLQRVRDEAHRFAITHHRKRRGKSMTRSTLDDVPGLGPSRQAALLQAFGSVRRIRAATPEEIAAVPGFGRRTAEQVLAALAPSPDDATTEPGAVGEPGTADGAAADPDGRDAVVVPEG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HNRPK_CHICK
Sequence: METEQQEETFTNTETNGKRPAEDMEEEQAFKRSRNTDEMVELRILLQSKNAGAVIGKGGKNIKALRTDYNASVSVPDSSGPERILSISADTETIGEILKKIIPTLEEYQHYKGSDFDCELRLLIHQSLAGGIIGVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPDRVVECIKIILDLISESPIKGRAQPYDPNFYDETYDYGGFTMMFDDRRGRPVGFPMRGRGGFDRMPPNRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRGGSRARNLPLPPPPPPRGGDLMSYDRRGRPGDRYDGMMMQCHVDACDDMQPPELFEGGSGYDYSYAGGRGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVKQYSGKFF
What is the function of this protein?
One of the major pre-mRNA-binding proteins.  Binds tenaciously to poly(C) sequences.  Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences.  Can also bind poly(C) single-stranded DNA.  May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression (By similarity).  As part of a ribonucleoprotein complex, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein K, hnRNP K.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm.
Protein: CYPC_STRCO
Sequence: MAGHTDNEITIAAPMELVWNMTNDIEKWPGLFSEYASVEVLGRDDDKVTFRLTMHPDADGKVWSWVSERVADPVTRTVRAQRVETGPFQYMNIVWEYAETAEGTVMRWTQDFAMKPDAPVDDAWMTDNINRNSRTQMALIRDRIEQAAGERRTASVLAD
What is the function of this protein?
Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptomyces coelicolor.
What are the official names of this protein?
Putative polyketide cyclase, WhiE ORF VI.
What is the protein family that this protein belongs to?
To polyketide cyclases.
Protein: APPY_ECOLI
Sequence: MDYVCSVVFICQSFDLIINRRVISFKKNSLFIVSDKIRRELPVCPSKLRIVDIDKKTCLSFFIDVNNELPGKFTLDKNGYIAEEEPPLSLVFSLFEGIKIADSHSLWLKERLCISLLAMFKKRESVNSFILTNINTFTCKITGIISFNIERQWHLKDIAELIYTSESLIKKRLRDEGTSFTEILRDTRMRYAKKLITSNSYSINVVAQKCGYNSTSYFICAFKDYYGVTPSHYFEKIIGVTDGINKTID
What is the function of this protein?
Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth.  It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase.  Also involved in the stabilization of the sigma stress factor RpoS during stress conditions.
What are the official names of this protein?
HTH-type transcriptional regulator AppY, M5 polypeptide.