PharMolix/UniProtQA huggingface dataset:
Protein: MANF_BOVIN
Sequence: MWATHGLAVALALSVLPASRALRQGDCEVCISYLGRFYQDLKDRDVTFSPASIEKELIKFCREARGKENRLCYYIGATEDAATKIINEVSKPLSHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASSRTDL
What is the function of this protein?
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain.  Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra.  Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons.  Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.  Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions.  Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia.  Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells.  Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions.
What are the official names of this protein?
Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET.
What is the protein family that this protein belongs to?
Belongs to the ARMET family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen. Note=Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia.
Protein: NQRE_VIBCH
Sequence: MEHYISLLVKSIFIENMALSFFLGMCTFLAVSKKVKTSFGLGIAVIVVLTISVPVNNLVYNLVLKPDALVEGVDLSFLNFITFIGVIAALVQILEMILDRFFPPLYNALGIFLPLITVNCAIFGGVSFMVQRDYSFAESVVYGFGSGVGWMLAIVALAGIREKMKYSDVPPGLRGLGITFITAGLMALGFMSFSGVQL
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit E, Na(+)-NQR subunit E, Na(+)-translocating NQR subunit E, NQR complex subunit E, NQR-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LOLA_ECOLC
Sequence: MKKIAITCALLSSLVASSVWADAASDLKSRLDKVSSFHASFTQKVTDGSGAAVQEGQGDLWVKRPNLFNWHMTQPDESILVSDGKTLWFYNPFVEQATATWLKDATGNTPFMLIARNQSSDWQQYNIKQNGDDFVLTPKASNGNLKQFTINVGRDGTIHQFSAVEQDDQRSSYQLKSQQNGAVDAAKFTFTPPQGVTVDDQRK
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YNEA_LISMO
Sequence: MTLKLIWDKFYVSIIFVLTCIVLGIILMCTVVGGGSDYSEVNVNEGDSLWALADQYAGKSDMAKADFVSWVEKENNLSDGHVEAGDSVVIPVHKTKLLKSDSTIQLANQ
What is the function of this protein?
Inhibits cell division during the SOS response.  Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and/or DivIC to the division machinery.
What are the official names of this protein?
Cell division suppressor protein YneA.
What is the protein family that this protein belongs to?
Belongs to the YneA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR4_CAEEL
Sequence: MSFITAFRERVFIASGDLIRTFRISEETELKNFISWSKINPERIQKPSFDIEKELKAVEKRVILCLAHSNVLTTHGRRLVAVGTNEKQIHVFEYFVNDKGDIVTAEHIVTSVVPKAPTAIVFDKEDAYVVVGDRAGDVHRFSVLNGSAIEMAGAISMILDVAFSPDGKRLLMADRDEKVRALRYPATSVIDSFFLGHTEYVKTLAVQDNDSLWSSGGDKNLYNWSIAKCSAPRRTLDLSQFDAPIRKISINLQHKKIAVIFEKIETVVIVDLNQESLQTTSVSIVGESQCLDIASTKDYFAVLGRSTVHLIDLNNMEQKFVPIDEELTITLTSTNDAIDNLFKNVTHNNQQEYEKRKADKFEQIEKKKRRLNEDINGDDGEGPGPSNS
What is the function of this protein?
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.  In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit, WD repeat-containing protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TXM1A_CORWE
Sequence: MRRFVFLAFVLVLFVIANLDSSSAQVNFSPDWGQGKRSGSSDTCAVCAQTMAQVYRLLQGLEAKLGQSRNYSR
What are the official names of this protein?
U-scoloptoxin(22)-Cw1a, U-SLPTX(22)-Cw1a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL18_SYNPW
Sequence: MSTLSRKQQTQKRHRRLRRHLSGTADRPRLAVFRSNSHIYAQVIDDAAQSTLCSASTLDKDLRTSLTATGSTCDASVAVGELVAKRALAKGIQQVVFDRGGNLYHGRVKALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: EASE_ARTBC
Sequence: MLTGVLQDWVWEAGETANESCPVGSLRTASAVNSCHQGRIPLFTVGVESTKQVQEAVRFARKHNLRLVIRNTGHDLAGRSSAPDSFQIHTHHLQEIQFHADMRLDGSNTSLGPAVTVGAGVMMGNLYAQAARHGYMVLGGDCPTVGVVGGFLQGGGISDFLSLNQGFGVDNVLEYEVVTADGELVVANALQNQDLFWALRGGGGGTFGVVTRATMRVFPDVPVVISEILLEAPQAISSSWTQGLSIVLTALQSLNRDNVGGQLVIAVLPKLAVQASIKFFFLDATEATVIDRRMKPFLTKLSRANVKYTYSSKNLPHFSSNYRQVPDIHSDNDYGVLGSTVAISQQLFDSPQGPEKVATALANLPVSAGDLIFTSNLGGRVISNGELAETSMHPAWRSASQLINYVHTVEPSIEGRAKARERLTNTQMPMLYALDPNLKLSYRNVGDPNEKDFQQIYWGPNYGRLSNIKKKWDTDDLFFSKLGVGSERWDSEEQLCLLHA
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of fungal ergot alkaloid (PubMed:22403186).  DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:22403186).  The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (PubMed:22403186).  The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by easD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:22403186).  Chanoclavine-I aldehyde is the precursor of ergoamides and ergopeptines in Clavicipitaceae, and clavine-type alcaloids such as fumiclavine in Trichocomaceae (PubMed:22403186).  However, the metabolites downstream of chanoclavine-I aldehyde in Arthrodermataceae have not been identified yet (PubMed:22403186).
What are the official names of this protein?
FAD-linked oxidoreductase easE, Chanoclavine I synthase, Ergot alkaloid synthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: PCKG_SACEN
Sequence: MTSLTIPGLDQAPTTHARLLSWVREVAELTTPDRVVWCDGSQDEWQRLTEQLVEAGTFKRLEKKPNSFYAASDPSDVARVEERTFICSREEKDAGVTNYWMQPDEMKAIMTELYRGCMRGRTMYVIPFCMGPLDADKPKLGVEITDTAYVVVSMHIMTRMGSKVLERLGEDEDFVEALHSVGAPLEPGQQDVPWPCNDTKYITHFPEERKIWSFGSGYGGNALLGKKCFSLRIASAMARDEGWLAEHMLILKLISPEDKVHYVAAAFPSACGKTNLAMLQPTIPGWRVESLGDDIAWMRFGEDGRLYAVNPEAGFFGVAPGTNWKTNPNAMRTIDQGNSLFTNVALTDDGDVWWEEMEGEPQHLTDWKGRDWTPQSDEKAAHPNSRYCTPMSQCPILAPEWDDPNGVPISAILFGGRRKTTIPLVNEAFDWQHGVFMGATLSSEKTAAAAGKVGEVRRDPMAMLPFIGYNVGDYFQHWVNVGKEADSSKLPRIFYVNWFRRDESGKKIVWPGFGENSRVLKWIVERLDGNAAAEDTPIGRVPSADQIDLSGLDTPREDVETALHVDVEEWKAELPLIEEWFASIGDSLPSSMRDEFEALKQRLGA
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_THEVO
Sequence: MARKKISVIGAGNVGATVAQFLATKELGDVYLFDVVDGIPEGKALDIQEGAPHWGYDLDVVGFSTSDSSNYKNMEGSDVIVVTAGMARKPGMSREDLFDKNVEIIADVSKNIKKYSPDSIIVVVSNPADIMAYALQKISGVDPQRIMGLGGSLDSSRFRTFLAKELDVSVEDVNAFVIGGHGDDMVPFIRYSSVAGIPIEKLLPKEKIDAIVKRTRFGGGEIVNYLKAGSAYYAPGISITAMVESVIKDKKRVIPCAAYITGKHAEHYGINNKFIGVPIKIGERGVEEIYDIDFLPEELELWKKSVASVEASSKNVDEWLKKHPQ
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily.
Protein: P2C15_ARATH
Sequence: MASREGKRRNHNHDDEKLVPLAALISRETKAAKMEKPIVRFGQAAQSRKGEDYVLIKTDSLRVPSNSSTAFSVFAVFDGHNGKAAAVYTRENLLNHVISALPSGLSRDEWLHALPRALVSGFVKTDKEFQSRGETSGTTATFVIVDGWTVTVACVGDSRCILDTKGGSVSNLTVDHRLEDNTEERERVTASGGEVGRLSIVGGVEIGPLRCWPGGLCLSRSIGDMDVGEFIVPVPFVKQVKLSNLGGRLIIASDGIWDALSSEVAAKTCRGLSAELAARQVVKEALRRRGLKDDTTCIVVDIIPPENFQEPPPSPPKKHNNFFKSLLFRKKSNSSNKLSKKLSTVGIVEELFEEGSAMLAERLGSGDCSKESTTGGGIFTCAICQLDLAPSEGISVHAGSIFSTSLKPWQGPFLCTDCRDKKDAMEGKRPSGVKVI
What are the official names of this protein?
Probable protein phosphatase 2C 15, AtPP2C15.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: XL3A_MOUSE
Sequence: MSSRERKATDTAGRHSRMDPNLSSDDSQNPGAVAAANREVLDAGREDIISSGTERQQARKEKQDLVQEFEEPPNKVLQENREKFSRIMTSSFSAMEVKIKDVLKTQCEQRQKLCQDYSLQFTNLSRKLTSDAYKLKKQAETLSNMFMEQQKFIHETLTLQKNRMEEFKSLCEKYLEKLEVLRDSRGNSIAEELRRLIATLEIKLLMLHNQQNTAAPPQSLLDVLFS
What are the official names of this protein?
X-linked lymphocyte-regulated protein 3A.
What is the protein family that this protein belongs to?
Belongs to the XLR/SYCP3 family.
Protein: GATA_SYNJA
Sequence: MSVIRALHRQLVTKERSAEEIAREYLERLAQLEPQLKSFITVTEELALQQAKAVDARIRAGEEIGPLAGIPLAVKDNLCTQGIRTTCASRMLEGFIPPYESTVTARLAAAGMVTVGKTNLDEFAMGSSTENSAFQRTANPWDLTRVPGGSSGGSAAAVAADQAVVALGSDTGGSIRQPAAFCGVVGLKPTYGLVSRYGLVAFASSLDQVGPFGRTVEDVALLLQGIAGHDPLDSTSLKVEIPDYSQALIPEIKGFKIGVIRDLLGEGCGEETRAAVQAAIQHLEELGAEILEIDCPSFRYGLATYYIIAPSEASSNLARYDGVKYGLREPADSLLAMYGKTRARGFGPEVKRRIMIGTYALSAGYYDAYYLKAQKVRTLIKQDFLRAFEKVDVLVSPTTPTPAFKAGEREDPLSMYLCDLMTIPVNLAGLPGLSLPCGFANGLPIGLQIIGNVLQESKVLRVAYAYEQSTDWHKRRPPLGQPPLEQAQGTAQQPKAKSKSTKGSKKSKS
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: IL1B_ONCMY
Sequence: MDFESNYSLIKNTSESAAWSSKLPQGLDLEVSHHPITMRHIANLIIAMERLKGGEGVTMGTEFKDKDLLNFLLESAVEEHIVLELESAPPASRRAAGFSSTSQYECSVTDSENKCWVLMNEAMELHAMMLQGGSSYHKVHLNLSSYVTPVPIETEARPVALGIKGSNLYLSCSKSGGRPTLHLEEVADKDQLKSISQQSDMVRFLFYRRNTGVDISTLESASFRNWFISTDMQQDYTKPVDMCQKAAPNRLTTFTIQRHN
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: RIHC_ECO57
Sequence: MRLPIFLDTDPGIDDAVAIAAAIFAPELDLQLMTTVAGNVSVEKTTRNALQLLHFWNAEIPLAQGAAVPLVRAPRDAASVHGESGMAGYDFVEHNRKPLGIPAFLAIRDALMRAPEPVTLVAIGPLTNIALLLSQCPECKPYIRRLVIMGGSAGRGNCTPNAEFNIAADPEAAACVFRSGIEIVMCGLDVTNQAILTPDYLSTLPQLNRTGKMLHALFSHYRSGSMQSGLRMHDLCAIAWLVRPDLFTLKPCFVAVETQGEFTSGTTVVDIDGCLGKPANVQVALDLNVKGFQQWVAEVLALVP
What is the function of this protein?
Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.
What are the official names of this protein?
Non-specific ribonucleoside hydrolase RihC, Purine/pyrimidine ribonucleoside hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihC subfamily.
Protein: ASNA_STRA3
Sequence: MKKSFIHQQQEISFVKNTFTQYLIDKLEIVEVQGPILSQVGDGMQDNLSGIEHPVSVKVLNIPEAEFEVVHSLAKWKRHTLARFGFNEGEGLFVHMKALRPDEDSLDPTHSVYVDQWDWEKVIPDGRRNLDYLKETVEKIYKAIRLTELAVEARFDIESILPKRITFIHTEELVEKYPDLSPKERENAIAKEYGAVFLIGIGGELADGKPHDGRAPDYDDWTTPSENGFKGLNGDILVWNEQLGTAFELSSMGIRVDEDALKRQVVLTGDEGRLEFEWHKTLLRGFFPLTIGGGIGQSRLAMFLLRKKHIGEVQSSVWPKEVRDTFENIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_DESVH
Sequence: MSRLLVDDPCRAAWRLPIALRDISGVFAAMQCATGLEGFEVELTIADDALIAMINEEQLGCIGPTNILSFPAYGAPPDYPADGMECGTGQDAHTSLPLLGSLVLSVDTLRREAFLYGQPVQEHCLRLLAHGLGHIAGYDHGAEMEAFEEAAREAALATRTAR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_CAMJJ
Sequence: MTKKEMLYEGKGKKLFKTDDENLLISEFKDDLTAFNAEKRGNESGKGALNCKISTEIFHLLEKNGIKTHLVETISDTEQVVKKCKIVPIEVIVRNVATGSLTKRLGIKDGTVLPFALVEFCLKDDALGDPFINDEHCLILNLVQNEAQISEIKNMARKINSILTPFFDNKNLRLIDFKIELGLTKDNELVLADEISPDSCRFWDKFSNEKLDKDRFRQDLGNVKMAYEEVLKRILN
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RECF_ACIC1
Sequence: MYLSRLELTDFRSYRRAALELDPGVNVFVGSNGQGKTNLVEAVCYLALLRSHRTATDAPLVRQGSERAVLHGEVLTSGRRIDLDVEIVPGRANRLRVNGHATRRARDLVGILRVVIFAPEDLALVKGDPAARRDYLDDVLVELRPRLFAVRAEYEKALRQRNAFLRAVAQDGQQVDRNSLDVWNLHFARAAAALLDARRRLVHELAPFVEKAYAAISGGSGAVRLEYRSTVPEEVLQDADEETRIAGILAALRKVQDAELARGLTLVGPHRDDLNLELDSRPARGYASHGESWSYALALRLGAYELLRSDGETPVMILDDVYAELDQQRRRRLTGCVSGAEQLLITSAVDEPDLPVGRRYVVHESQVHVAD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPDF_BRASO
Sequence: MTTSQRTAAILVAAGRGLRAGAGGPKQYRTIGGRTVIHRALAAFAEHPEVAVVQPVVNPDDIDVFNAAVAGLRHEAPARGGATRQASVLAGLEALVPHKPEIVLIHDAARPFVTPAVISRAIIAANKTGAAIPVAPVTDTIKEVGASGDITATPERAKLRIAQTPQTFRFDTILEAHRRAAREGLTEFTDDAAIAEWAGLTVATFEGDVANMKLTTPEDFVREEARLAASLGDIRTGTGYDVHAFGEGDHVWLCGLRVPHTKGFLAHSDGDVGLHALVDAILGALADGDIGSHFPPSDMKWKGASSDQFLKYAIERVAARGGRVANLEVTMICERPKIGPLRDQMRARIAEISGVDISRIAVKATTSERLGFTGREEGIAATASATIRLPWGA
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: F234A_MOUSE
Sequence: MMDNKDLEAEIHPLKNEDKKSQENPGNLPRNEDNLKSKPVPSRLSRCRTVAFFLSLFTCLFVVFVLSFIIPCPDRPSSQGTWKLDYNNAVMYDFLALGDINKDKVQDVLFLYKNTNSSNNLTRSCADEGFSTPCAFVVAVSGANGSVLWERPVAQDVALVKCAMPQTLDSDEVSSACIVVGRAGSFVAVSFFTGETLWSHPSSFSGNVSILSPLLQVPDIDGDGDGTPDLLILAQEGQEVSGALYSGSTGYQIGHRGSLGVDGDGVALLHVTRTGAQYILLPCASALCGFSVKSLYERITGRDGHFKEDPYWENMLNHSVHRRLLHRLGAVRYLMNIPGKAGQDLLLVTSEACVLLDGQDLEPRWTLGEVQVLRKPILGHYKPDTLAVVIENGTSIDRQILLLDLSTGSILWSQPLPSLPGGPPSTSLMTADHRSAFFFWGLHDLVSTNEMDPPDVQHSLYMFHPTLPGILLELANVSANIVAFDAVLLEPSRHAAYVLLTGPASSDVPGLVSVTKHKVQDLVPGSRVIHLGEGSSDSDQAIRDRFSRLRYRSEM
What are the official names of this protein?
Protein FAM234A, Protein ITFG3.
What is the protein family that this protein belongs to?
Belongs to the FAM234 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: NOXO1_HUMAN
Sequence: MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCVDSVPHPTTEQ
What is the function of this protein?
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.  Isoform 3 is more potent than isoform 1 in activating NOX3.  Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
What are the official names of this protein?
NADPH oxidase organizer 1, NADPH oxidase regulatory protein, Nox organizer 1, Nox-organizing protein 1, SH3 and PX domain-containing protein 5.
What are the subcellular locations of this protein?
[Isoform 3]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910).
Protein: DXR_CERSK
Sequence: MRSLSIFGATGSIGESTFDLVMRKGGPEAFRTVALTGGRNIRRLAEMARALKAELAVTAHEDCLPALREALAGTGTEVAGGAQAIAEAADRPADWTMSAIVGAAGLVPGMRALKHGRTLALANKESLVTAGQLLMRTAQENGATILPVDSEHSAVFQALAGEDTACVERVIITASGGPFRDWSLERIRACTVAEAQAHPNWSMGQRISIDSASMFNKALELIETREFFGFEPDRIEAVVHPQSIVHAMVGFCDGGLMAHLGPADMRHAIGFALNWPGRGEVPVARIDLAQIASLTFQKPDEERFPALRLARDVMAARGLSGAAFNAAKEIALDHFIAGRIGFLDMAAVVEETLAGVSTDPLFGKVPDALEEVLAMDHLARRAAEEAAGLRQQKR
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: GSXLY_ARATH
Sequence: MAPSLSPIRSHHVAVIGAGAAGLVAARELRREGHSVVVFERQKQVGGTWIYTDHIEPDPLSVDPTRSVVHSSVYGSLRTNLPRECMGYRDFPFVVRSGVSESRDPRRFPSHGEVLAYLQDFAKEFAIEEMIRFDTAVVKVAPAAEEGSGKWRIESTEKEKKKWAHRAV
What is the function of this protein?
Catalyzes the conversion of methylthioalkyl glucosinolates of any chain length into methylsulfinylalkyl glucosinolates.
What are the official names of this protein?
Putative flavin-containing monooxygenase FMO GS-OX-like 11, Putative flavin-monooxygenase glucosinolate S-oxygenase-like 11.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
Protein: CYSI_OCEIH
Sequence: MTKSNISKDNGPLDEVEGIKERSNFLRGTIAEGLEDRITGAISDEDNKLLKFHGSYQQDDRDLRDERRRKKLEPAYQFMIRVRTPGGVTTPEQWLVMDDLAHKYANGSMRLTTRQTFQLHGIVKWDLKKTMQGMNQALMTTIAACGDINRNVMCNVNPEQSDVHAEVYEWSKKVSDHLLPETNAYHEIWLEDKKIVDSREESEPIYGSTYLPRKFKIGIAVPPSNDIDIYSQDLGFIAIVEEGKLLGFNVAVGGGMGMTHGDTNTYPQISRVIGFCVPEKVTEVAEKVVTIQRDFGNRSNRKNARFKYTIDSRGIDWFIDELNERLGWELEGKRHYEFDSNGDSYGWIEGKDYWHLTLFIQNGRIKDVEDYPLMTGLREIAKVHTGDFRLTPNQNLIIANVSSDNKKQINDLVEKFNLTEGKTYSGLRRNSMACVAFPTCGLAMAESERYLPELLDKIEVILDESGLREEEIVIRMSGCPNGCSRPALAEIAFIGKAPGKYNMYLGGSFNGSRLNKLYKENIGEEEILNTLRPIFIDFAKDKQKDEHFGDFVIRAGYVEEVKSGLDFHSSKEDVRS
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: RS4_METM7
Sequence: MGDPRRLGKKYDTPNHPWIGERIQSEREISQKYGLVNKKELWKMETQLRNYRRQARKLISDTTTQGGKEAVQLFNVLKRYAILVEQEPTLDHVLSLNIESILERRLQTMVYKKGLAKTAKQARQFIVHGHIAVNGKRVTSPSYLVSVAENDAIEYVPNSPMASENHPERTAAVSEENQ
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: URE1_CORU7
Sequence: MAYEISRQQYGELYGPTTGDGIRLADTDLVLRIEKDLTAKGDEVGFGGGKVIREGMGMNARMTRDEGVVDTVITNAIIVDHTGIYKADIGIRDGLIEGIGRAGNPDVQDDIDIPVGVNTEAYAGEHTIVTAGAIDTHIHFISPDQFDTALSNGTTTFIGGGTGPADGTKATTITPGEWHIHRMIEATSDAPVNIGLLGKGHAAVPGPLKAQIRAGAIGLKIHEDWGATRSAIDTSLRVADELDVQIAIHTDTLNEYGYLEDTIKAIDHRTIHTFHTEGAGGGHAPDIIAIAGEKNVIPASTNPTLPFTKNTVDEHLDMLMVCHHLNKDIPEDVAFADSRIRGETIGVEDVLHDLGVFSITSSDSQAMGRVGEVVLRTWQVAHINKQQRGPLEGDSEGNDNNRIKRYVSKYTINPAIAHGISHLVGSVEVGKMADLVLWEPRFFGIKPKVVLKSGQAAYSEMGDSNGSIPTPQPVTYRRNWGATGAASETAAVTFVPSVALQSGVEDKLRGGRALLEARDMREITKKDLKHNAATPKIEVDPQTYQVRLDGELVEGSKPTETLPMGQKYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.