PharMolix/UniProtQA huggingface dataset:
Protein: RLME_AFIC5
Sequence: MAKDTTGRLHVTVKSGGKRKLSSKLWLERQLNDPYVAQAKRDGFRSRAAYKLREMDDKYHFLKQGQAVVDLGAAPGGWSQIAAKRVGAEAGRGKVIAIDLLEMGEIPGVTFAQLDFLSDDAPEKLRAMLGGGADIVMSDMAANTTGHRKTDQLRIVGLVESAAAFAAEVLNPGGTFLAKVFQSGADATLQAELKRNFATVRHVKPAASRQDSSERYVLAMGFRGG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1221_MYCLE
Sequence: MVQDLPTPIGAGIYNIYTGVKHRDELAGASMPTVAQLGLEPPRFCAECGRRMVVQVRPDGWRAKCSRHGQVDSVDMEAKR
What are the official names of this protein?
Uncharacterized protein ML1221.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1590.
Protein: TRMD_ACIAC
Sequence: MRFDVITLFPELFTPFLASGVTRRAYATGLVDVRFWNPRDYAEGNYRRVDDRPFGGGPGMVMMAEPLERCLRAIRADRGEAPEAVAPLVMFSPIGRRLDHDGVAGWAAGNGAVLLCGRYEGVDQRFVDAHVDVQLSLGDFVLSGGEIPAMALLDAVARLQPGVLNDAGSHQEDSFNAALDGLLDCPHYTRPESWQGQAVPAALLSGHHAQIERWRRDQRLAVTARHRPDLVEAARVAGRLDRADEAVLAKLNGLL
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BLI1_YEAS7
Sequence: MGEQNKLYYDVEKLVNSLQESFDLDCAQSVSLFTSKSRSNEAWLEELENKFKLKDDVELDDVENLRAEIDMKLNMLEDKVSYYERLYKELEEFQNEIKIKTVVNNRRQSRTPK
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit BLI1, BLOC-1 subunit BLI1, BLOC-1 interactor 1.
What is the protein family that this protein belongs to?
Belongs to the BLI1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: HMGN5_HUMAN
Sequence: MPKRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSIV
What is the function of this protein?
Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.
What are the official names of this protein?
High mobility group nucleosome-binding domain-containing protein 5, Nucleosome-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the HMGN family.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.
Protein: ADIPB_XENLA
Sequence: MGDWRTISLPESDKILQYSSEIRMSPTSLLSSPSHSAANTLSGIVYNFCTEDNIEQCITYIDQELRTIGFPTVQAVSKNGDGRKLHLVSIVNCIHELLQRNSQNMRSKEEVETQLLKINGDLEHLQSIYQRQKDQMEATRRENCALQERDRQMQCKNRNLLQLLKNEKEEVQKLQNIIASRSTQFNHSVKRKEREYNKLKERLYQLVMDKRDKKISIDVLNYVGRADGKRTSWRTGKTDAKNEEEMYKVLLNDYEQRQKQLMVENAELKKVLQQMKKEMISILSQRKTKEKLDDSIGPVASDIEEDLADSSKENLSELSCEAVREQLVSSIRQQWRILKSHMEKLDNQATPDENGMIARGDHEQELGKLINEIQQCKETIKIQQQLLKQQFSVPRDDTSTLLQDCYLLEDKERLQEEWKLFNEQKKNFEKERRNFTEAAIRLGHEKKAFEEDRAAWLKHQFLNMTVFTDHKNSEEKRAHGVHFSPEQDHCRLHSRTHDRHLASSGDHYQRPRKTLPITPSSKHSLTQRESVAWRDSSISPNGTDF
What is the function of this protein?
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs).  Involved in cell movement.  Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles.  The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (By similarity).
What are the official names of this protein?
Afadin- and alpha-actinin-binding protein B, ADIP-B, Afadin DIL domain-interacting protein B, SSX2-interacting protein B.
What is the protein family that this protein belongs to?
Belongs to the ADIP family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Protein: Y404_STAAN
Sequence: MKSIKRIGLCISLLILIIFATSCGSNKITGDSKEEQIKKSFAKSLDKYPTENLEEFYDKEGYRDGEFEKDDKGTWLIRSEMKIQLKGENLESRGAVIEINRNTRTAKGNYIVREVVEDSDGMTHNHTKRYPVKMENNKMIPLKSIDDEKVKKEIEEFKFFVQYGNFKELENYKEDEVSYNPEVPIYSAQYQLKNSDYNVEQLRKRYNIPTQKAPKLLLKGSGNLKGSSVGYKNIEFTFVENKEENIYFTDSVYFNPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SA0404.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: CFM3_MAIZE
Sequence: MAMASSPACHFRHPPRLRLLLPLSTSAPHPWLYSWSHPRQRGRLRAPPAALDLRPEPSPSSDSDDEDAVGASRSSGRSTMSLILSRLRRAGYSGEDPRAAAPPHPPRGSVEDVFRADDGVLPNARGGFDADDEERALGDARFPWERPMPPPEAAPRSARSPTWMAELTLPAAELRRLRHAAIRIKSRTKVGGAGVTREIVEKIKEKWKTEEVVRVKVSGTPALNMRLFHEILERKTGGLVIWRSGTSVSLYRGVDYDEPEPTKKSKKNSQSLAMDFPIKGSSNPSLLPTETANSVRDSNVALVSNAAKEELVVQAPEIKYEDEIDKLLDELGPRYTDWPGSDPLPVDADLLPANMPGYKPPFRVLPYGVRPSLSRRDTTNLRRLARGLPPHFALGRSRQLQGLANAMVKLWEKSSIAKIALKRGVQLTTSERMAEDIKKLTGGVMLSRNNEFIVFYRGKDFLSSELAEVLLERERLAKSLQDEEEARRKAASYFSSAETYAQPTVAGTLGETLEANSKYGTKHDENHADKMARTIEAARHADLVRKLEWKLSLAQKKMEKAERVLGKVETALRPTEDSRPPETITDEERFMFRKLGLRMKAFLLLGRRGVFDGTIENMHLHWKYRELVKILVKAKSFADVKRIALSLEAESGGILVSVDKVSKGYAIVVFRGKNYRRPSSLRPRNLLSKRKALARSIELQRHQALSRHFAKLNRKVERLKAELVQMEDVKEQGDEELYAKLDAAYSSDDEDMEDEDDEAYLKRFDNEVAGATADDDGSDDYTSAADEADYPDSDDEAGDCSEDEGEDDEDEAAAGVSDAGFHGEVVGFSSDTDRRNHDVNEY
What is the function of this protein?
Binds specific group II introns in chloroplasts and facilitates their splicing.  Acts on subgroup IIB introns.  The substrates of the subgroup IIB also require the CRM domain proteins CAF1 or CAF2, with a simultaneous binding of CFM3 and CAF1 or CAF2 (PubMed:18799595).  May influence the biogenesis of the mitochondrial small ribosomal subunit (By similarity).
What are the official names of this protein?
CRM-domain containing factor CFM3, chloroplastic/mitochondrial, Protein CRM FAMILY MEMBER 3, ZmCFM3.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Mitochondrion.
Protein: RPOA_BARQU
Sequence: MIQKNWQELIKPNKVEFCTHDNPNISSVIVEPLERGFGLTLGNALRRVLLSSLRGAAITAVQIDGVLHEFSSIPGVREDVTDIILNIKEIALRMQEEGPKRVVVCKEGPGVVRAGDINTVGDMEILNPEHVICTLDEGAEIRMEFIVNTGKGYIPSDRNCVDDGRIGLIPVDSLYSPIRKVSYKVENTREGQVLDYDKLTLTIETNGAVNGEDAVAFAARILQDQLSLFVNFEEPQKEIVDESDSELTFNPALLKKVDELELSVRSANCLKNDNIVYIGDLIQKTESEMLRTPNFGRKSLNEIKEVLACMGLHLGMEIPTWPPENIDDLAKRYEDQY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: Y3968_RHILO
Sequence: MADDITETSQTVAAGQLRALIERIERLEEEKKTIADDIKEVFAEAKGTGFDTKAIRTIIRLRKKDQAERQEEDAILDLYMAALGMV
What are the official names of this protein?
UPF0335 protein mll3968.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: GRA1_TOXGO
Sequence: MVRVSAIVGAAASVFVCLSAGAYAAEGGDNQSSAVSDRASLFGLLSGGTGQGLGIGESVDLEMMGNTYRVERPTGNPDLLKIAIKASDGSYSEVGNVNVEEVIDTMKSMQRDEDIFLRALNKGETVEEAIEDVAQAEGLNSEQTLQLEDAVSAVASVVQDEMKVIDDVQQLEKDKQQLKDDIGFLTGERE
What are the official names of this protein?
Dense granule protein 1, Protein GRA 1, Major antigen p24.
What are the subcellular locations of this protein?
Secreted. Note=Located in dense granules of tachyzoites.
Protein: KTHY_STRP4
Sequence: MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGVLIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSSVAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDLEGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKAVLFDGMGLAK
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: MSRA_LISIN
Sequence: MTKESLEKATFAGGCFWCMVKPFDTQPGIEKVVSGYTGGHTVNPTYKEVCSGTTGHTEAVEITFDPAVFPYEKLVEVYWQQTDPTDAAGQFVDRGDSYRPVIFYHNEEQRQIAEKSKAALDASGRFKKPVVTEIAKAETFYPAEEYHQDFYKKEKAHYEGYQVASGRAAFIDANWKG
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: NCAP_I60A2
Sequence: MASQGTKRSYEQMETGGDRQNATEIRASVGRMVSGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWMRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMESARSEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: TSAD_TREDE
Sequence: MKILGIESSCDETAAAVVEDGNKILSNIVATQIPFHKMYNGVVPEIASRKHTEWILPVVKQALAEAGLSLKEIDGIAATGRPGLMGSLLVGLTFAKTLAWSSNKPFIAVNHMLGHLYASHLENDIPYPYLGLLVSGGHSIICKVNNFDDIEVLGTTIDDAPGEAFDKVAKFYNLGYPGGAVIDKLAKSGNPKAANFPMPIIHKEGHKYDVSYSGLKTAVINQIDQFWNKDFEKTPENIAAAFQTRAVKILLRPLLDASIDTGLKTIVAGGGVAANSLLREKLAEHKELKCIFPSLKFCTDNAAMIAGLGYHYLKRGDRTPFTVEASARVEGFSKKGRQ
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDHC_PIG
Sequence: MSTVKEQLIENLIEEDEVSQSKITIVGTGAVGMACAICILLKDLADELALVDVAVDKLKGETMDLQHGSLFFNTSKIVSGKDYSVSANSKIVIVTAGARQQEGESRLALVQRNVNIMKSIIPTIVQHSPDCKMLIVSNPVDILTYVAWKLSGLPATRVIGSGCNLDSARFRYLIGKKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKDQWKNIHKQVIGSAYEIIKLKGYTSWAIGLSVTDLVGSILKNLRRVHPVSTMVKGLYGIKEEIFLSIPCVLGRNGVSDIVKVNLNAEEEALFKKSANTLWNVQKDLTF
What is the function of this protein?
Possible role in sperm motility.
What are the official names of this protein?
L-lactate dehydrogenase C chain, LDH-C, LDH testis subunit, LDH-X.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSA_CAMJE
Sequence: MKKMILIAGPCVIESKDLIFKVAEQLKNFNENPNIEFYFKSSFDKANRTSINSFRGPGLEEGLKILQSVKDEFGMKILTDIHESNQANPVSEVADVLQIPAFLCRQTDLLVAAAKTKAKINIKKGQFLNPSDIKYSVKKVLQTRGIEDEGYEAAQRNGVFVAERGASFGYGNLVVDMRSLVIMREFAPVIFDATHSVQMPGAAGGSSGGKSEFVEPLARAAAAVGIDGFFFETHINPCEALCDGPNMLNLTRLKNCVNTLLEIQNIIKENK
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_HYDCU
Sequence: MAGSENKARTMQGVVVSNGMDKSVVVMTNRYIKHPKYKKFVRKSTKVMAHDADNACGVGDRVTISECTPFSKRKTWSLVSIDEKAAL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: FABZ_XANC8
Sequence: MSHPIYELPIDVNQIQTLIPHRYPFLLIDRVIELDLEAKRIVGQKNVTINEPFFQGHFPTRPVMPGVLIIEALAQAGGVMTQLGLGRDALSKLFYMVKVDNARFNKQVVPGDVLILEVQMKRLIRNMGCYYGEAKVNGEIVASAEVMCAGARE
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T132A_RAT
Sequence: MTERAAAAPRGPYGAWLCLLVALALEVVRVGSNQNTLDPIYLPVALELLDAPEHFRVQQVGHYPPANSSLGSRSETFLLMQPWPRAQPLLRASYPPFATQQVVPPRVTEPHRRPVPWDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLPCARLHATHPAGTAHQACRFQPSLGACVVELQFPSQWFSQSATTRAELAYTLEPAGEGPGGCGPGTEEEPKEQALPVGSVELHPEDPPQHQEVPLDEVVTLRAPDVPVRPGQLFTATLLLRHNFTASLLTLRIKVKKGLQVTAARPAQPTFWTAKLDRFKGSKHHTSLITCHRTGPAGPDSRPLELPEFLWVDFAVENSTGGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILFSERDIRALIPLAKAEELVNTAPLTGVPQRIPVRLVTVDSGGALEEVTEHIGCESANTQVLQVSEACDAVFVAGQESRGAKGVRVDFWWRRLRASLKLTVWAPLLPLRIELTDTTLEQIRGWRVPGPAEGQLEPEAAAEEVERRSRGCRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAAHAHVQDPRIATLEGGRILVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLDLRVQPVMGISLSLSRGVSHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDRNDLGLSVSAEEPSAVVPAEEQRAQLGVVVSGVGAKGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPLPTPAPALPSSPARTPPFTEASVEGKRQVAGDMGSHVGPGIRGKFERAEEEAGKEENEAKEEEEDEEEMVPAPQRVTDLELGMYALLGIFCLAFLIFLVNGVVFVLRYQRKEPPDSVTDPASPQPHNWVWLGTNQEELSRQLDRCSSSSPPKGEGGCPCESGAGGDTSTVAPSASESPAGSTSTLARKEAGGRRKRVEFVTFAPAPPAQEAPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIRGSS
What is the function of this protein?
May play a role in embryonic and postnatal development of the brain.  Increased resistance to cell death induced by serum starvation in cultured cells.  Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation.
What are the official names of this protein?
Transmembrane protein 132A, GRP78-binding protein, HSPA5-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the TMEM132 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: VATE_DEIDV
Sequence: MALDKLLEQEAQSEIERIRAEARDRSQMIVAQAQERAQALIESRQRALETQRQAGIVRARSAADLDLNAARLTASESGMSQVYELVNQQITEITRVPEYRDILGRLIYQAREVITDAEAVEVNPAEAALARELVHDIAVRENPAIQGGVRVVARGGKSGITNTLAGRLERVRGELAPQVSRLLAE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type proton ATPase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: CAPP_MYCUA
Sequence: MVEVSDTALEPIGDVHRTRIGREATEPMRADIRLLGAILGDTVREQNGDEVFELVERARVEAFRVRHSEIDRAEMARMFEGIDIHHAIPIIRAFSHFALLANVAEDIHRERRRSIHVAAGEPPRDSSLTATYMKLYAAQLDSATIAEALKGALVSPVITAHPTETRRRTIFETQHRITQLMRLHAEGHTETDDGRGIEVELRRQVLRLWQTALIRLFRLQISDEIEVGLRYYPAALFEVISQVNAEVRDALRARWPDADLLSEPILRPGSWIGGDRDGNPNVTAEVVRLATGSAAFTALAHYLAELTALAQELSMSARLITVTPELATLADACPAGARPDEPYRRALQVVRGRLSATAAEILDQQPQHTLELGLPPYATAAELRADLDTIDASLHNHGAGLLADDRLARLREAVRVFGFHLSGLDMRQNSDVHEQVVGELLAWAGVHPDYTSLAEAERVELLAAELSTRRPLIRDGAQLSDLARSELGVLAAAAHAVWTFGPAAVPNYIISMCWSVSDMLEAAVLLKEVGLLDASESEPYCPVGISPLFETIEDLHNGAAILQAMLDLPLYRALVTARGGCQEVMLGYSDSNKDGGYLAANWAVYRAELALVETARKTGIRLRLFHGRGGTVGRGGGPSYQAILAQPPGAVSGSLRLTEQGEVIAAKYAEPQMARRNLESLLAATLESTLLAVEGLGDTAAPAYAVLDEVAALAQRAYAELVHETPGFVEYFKASTPVSEFGALNIGSRPTSRKPTASIADLRAIPWVLAWSQSRVMLPGWYGTGSAFEQWLAAGPESEADRLQVLHDLYQRWPFFRSVLSNMAQVMAKSDLELAARYSELVADETLRRRVFDKIADEHHRTIAMYKRITGQDDLLADNPALARSVFNRFPYLEPLNHLQVELLRRYRSGEDDESVQRGILLTMNGLASALRNSG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: SKP1_BOVIN
Sequence: MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK
What is the function of this protein?
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription.  In the SCF complex, serves as an adapter that links the F-box protein to CUL1.  The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.  SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling.  SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA.  SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2.  SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition.  SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1.  SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.  SCF(FBXW2) directs ubiquitination of GCM1.  SCF(FBXO32) directs ubiquitination of MYOD1.  SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5.  SCF(FBXO33) directs ubiquitination of YBX1.  SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53.  SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription.  SCF(CCNF) directs ubiquitination of CCP110.  SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2.  SCF(FBXO9) directs ubiquitination of TTI1 and TELO2.  SCF(FBXO10) directs ubiquitination of BCL2.
What are the official names of this protein?
S-phase kinase-associated protein 1, Cyclin-A/CDK2-associated protein p19, S-phase kinase-associated protein 1A, p19A, p19skp1.
What is the protein family that this protein belongs to?
Belongs to the SKP1 family.
Protein: CD112_CAEEL
Sequence: MSNYSTNGSRKIRISNSDDDSRETRFSIQPRNSHKTKEERYRDKEKERDHERHHDRERRDDRYRKVDSRDHRDRNRRSPAGSRTYCRDEPDRRRNNHSDRNRRDRSSERDRDNRSSKSKTKSPDSLRSKSSRKSQTPNHLPDDGKLFDRILDPNYKKKEKTVMEVEDVEMSPVEMLDEEEVSTFTFDDACGPVRPSNEPEEKDYKSEGDPESRPATPKTPLTPDYLENTIVSLNETLSDDEDKGPDDKYGKTPDKEQWESMTENEQKLHRDAMKKRREQRHREAVSKLPVYYPGLRGCQHISEYVILNVIAEGTYGEVFRGKNTRTDEVVALKRFKMEKEKEGFPITALREINMLLKAGAHENIVNVKEILVGSTKTEVYMAMEYVEHDVKSLIDKMRSRNQRFKTGQQKTLMSQLLSGIEHMHKLWILHRDLKTSNLLISHSGILKIADFGLAREYGEARDIEKRMKLTPIVVTLWYRSPELLLEPKTYSTPVDMWSIGCIMAEFIMMKPMFQGDSEPNQVHQIFQMMGTPTEQIWPDIKELKVWNMVEFPPVKPGQLRRIFKGEKLVNETGFDLLNGMLCLNPANRLTASEALQHDWFSEHPKAVPPEDLPVYPAKSELNAAPPENRRKNRLEALLADEEPERAALLRQFNVKAEQLKPSGFQLRG
What is the function of this protein?
Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L (PubMed:29886128).  Acts partially redundantly with cdk-11. 1 to ensure embryonic viability (PubMed:29886128).  In contrast to cdk-11. 1, not essential for male and female fertility (PubMed:29886128).
What are the official names of this protein?
Cyclin-dependent kinase 11.2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Evenly distributed between the cytoplasm and nucleus in embryos, but becomes more enriched in the nucleus from the 4- and 6-cell stage as embryos develop (PubMed:29886128). In the germline, localizes to the nucleus and cytoplasm in the mitotic region, but is enriched in the cytoplasm (PubMed:29886128). Nuclear localization increases as cells enter late pachytene, and then the distribution between the cytoplasm and nucleus becomes more even as oocytes mature (PubMed:29886128).