PharMolix/UniProtQA huggingface dataset:
Protein: PTTG1_MOUSE
Sequence: MATLIFVDKDNEEPGRRLASKDGLKLGTGVKALDGKLQVSTPRVGKVFNAPAVPKASRKALGTVNRVAEKPMKTGKPLQPKQPTLTGKKITEKSTKTQSSVPAPDDAYPEIEKFFPFNPLDFESFDLPEEHQISLLPLNGVPLMTLNEERGLEKLLHLGPPSPLKTPFLSWESDPLYSPPSALSTLDVELPPVCYDADI
What is the function of this protein?
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair.  Probably acts by blocking the action of key proteins.  During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes.  At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1.  Its function is however not limited to a blocking activity, since it is required to activate ESPL1.  Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53.  The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed.  May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity).
What are the official names of this protein?
Securin, Pituitary tumor-transforming gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the securin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RRF2M_EMENI
Sequence: MVSALLLRARQNGRAARCLDYPKVKCWALASLPKSSLEKPGFSQVRRFSVFHPQSQVNLDLTRNIGIIAHIDAGKTTTTERMLYYSGLTRRIGDVDEGSTVTDFLPAERARGITIQSAAITFHWPPAECGNATRQDPRSPRSASSHMVNLIDTPGHADFTFEVLRSLRILDGAVCILDGVAGVEAQTEQVWHQASTYNIPRIVYVNKMDRDGAAFGRTVREVASRLGGWPAVCQIPWFEGGDGRFVGVADAINLQGLLWSGGDGKSVKRFSLSELDEAESQLAQELRRARVALVELLSEHDEIIVEKFFENEEDHLSVSPADILDSLRRCLLEGNGRKIIPIFAGASFRNIGVQPLLDSVVDLLPSPQETPDPEVAIGGVKGSLRRLLSGDLLVEQKEKAAPKGKQKKKAAVVADSRNAIKQLHGCGLAFKVVNDAKRGVLVYVRVYSGSLDRGSLLYNTNLNVSERAPRLLKMYANDAVEVDSISEGQIGVVVGLKHARTGDTLVACTTNKATPPEPLDTLQLRPIDVPPPVFFASVEPHSLAEEKRMHESLALLLREDPSLHVSIDEDSGQTLLSGMGELHLEIARDRLINDLKAKATMGPIEIGYRECPLGASGPVTKIFDREIAGRKGKAGCTAEIEPFDPETSPAPDPAALSVEIANGNQIVILAPELQIETNKKGLEESPILPPGLDVDAVRSALSNGCLAALARGPQFTFPMHSTRVTLTLSPTAHIFGNETTSASLSAATRLATSTALSNLISNPASASATPGTCLMEPLMNVIISVDEASLGAVVHDISSSRGGHIVSLDEDVPIASTDLSIPNTETPDPELDLPPIDPAKVYAPPDPFQSSTVVGGSMASDARNRPRTITAKVPLKEMVGYLKHLRSLSAGRGTFVMSVDRFEKMSPPRQKAVLTELRGVY
What is the function of this protein?
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.  Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
What are the official names of this protein?
Ribosome-releasing factor 2, mitochondrial, RRF2mt, Elongation factor G 2, mitochondrial, EF-G2mt, mEF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NORR_ECOLU
Sequence: MSFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDSRQFIPLAIDGLAKDVLGRRFALEGHPRLEAIARAGDVVRFPADSELPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNALLIEQLESQNMLPGDAAPFEAVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLVYLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVDVRVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRERGDDVILLAGYFCEQCRLRLGLSRVVLSAGARNLLQHYNFPGNVRELEHAIHRAVVLARATRSGDEVILEAQHFAFPDVTLPPPEAAAVPVVKQNLREATEAFQRETIRQALAQNHHNWAACARMLETDVANLHRLAKRLGLKD
What is the function of this protein?
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon.  Activation also requires sigma-54.
What are the official names of this protein?
Anaerobic nitric oxide reductase transcription regulator NorR.
Protein: PTH_ACTSZ
Sequence: MSEIKLIVGLGNPGDKYADTRHNAGEWLIDRLSRRFNFTLKDEAKFFGKTARTVIDGHEIRFLVPATFMNLSGKAIGALASFYRIRPEEILLAHDELDLPPGTVKIKQGGGHGGHNGLKDTIAQLGNNKNFYRLRIGIGHPGDRNLVTSYVLGKPSPADWALIDKALDEAVVCVEILLKDGITKATNRLNGFKA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_CALS8
Sequence: MKKLYLIGKSLKHSISPLIHNKILSNFGIDAVYSNVELPDFEKLKEFVEMVKKDGDVVGFNITIPYKEDILEFCDEVSEDVRIIQAANTVKKEGEKLVAYNTDWLGFKRSLEEVGISVKDKRILILGAGGAAKACIYGLYRMGVKEVFVANRTYEKAESLKEVFQDILKILPVEWLRRYEFKYDIIINTTSVGMFPNIESSPFDFENYVAGIPVFVYDMIYNPPKTTFLEEAEKKGSKTENGLKMLVYQAVEAEKIWFDIVNLSQSFLLEILKECEKKI
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: CDPKI_ARATH
Sequence: MGLCFSSPKATRRGTGSRNPNPDSPTQGKASEKVSNKNKKNTKKIQLRHQGGIPYGKRIDFGYAKDFDNRYTIGKLLGHGQFGFTYVATDNNNGNRVAVKRIDKAKMTQPIEVEDVKREVKILQALGGHENVVGFHNAFEDKTYIYIVMELCDGGELLDRILAKKDSRYTEKDAAVVVRQMLKVAAECHLRGLVHRDMKPENFLFKSTEEGSSLKATDFGLSDFIKPGVKFQDIVGSAYYVAPEVLKRRSGPESDVWSIGVITYILLCGRRPFWDKTQDGIFNEVMRKKPDFREVPWPTISNGAKDFVKKLLVKEPRARLTAAQALSHSWVKEGGEASEVPIDISVLNNMRQFVKFSRLKQIALRALAKTINEDELDDLRDQFDAIDIDKNGSISLEEMRQALAKDVPWKLKDARVAEILQANDSNTDGLVDFTEFVVAALHVNQLEEHDSEKWQQRSRAAFDKFDIDGDGFITPEELRLQTGLKGSIEPLLEEADVDEDGRISINEFRRLLRSASLKSKNVKSPPGYQLSQKM
What is the function of this protein?
May play a role in signal transduction pathways that involve calcium as a second messenger.
What are the official names of this protein?
Calcium-dependent protein kinase 18.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor.
Protein: RNFE_SHESR
Sequence: MTNYREIAWQGLWKNNPGLVQLLGLCPLLAVTATLTNALGLGVATMLVLIGSNILVSLVRDYVPKEIRIPVFVMIIAALVTAVQLLINAYAYGLYLSLGIFLPLIVTNCIIIGRAEAFASRNNAFSAAFDGLMMGLGFTLVLAVLGATREILGQGTLFDGADQLLGPWAKALTIQVWQVDTPFLLAMLPPGAFIVMGLLIALKNVIDKKLKERQPEAAVQPSVTRARITKVS
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ADPRH_STRP1
Sequence: MPSSFDLLGEMIGLLQTEQLTSSWACPLPNALTKRQDLWRALINQRPALPLSKDYLNLEDAYLDDWRASFVPVSVKDCQKTNYTSLFLYHGDIRYLAVDAIVNAANSELLGCFSPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQAKLTSAYHLPASYIIHTVGPRITKGHHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSISTGEFGFPKKEAAQIAIKTVLKWQAEHPESKTLTTIFNTFTSEDKALYDTYLQKENNCE
What is the function of this protein?
ADP-ribose glycohydrolase that hydrolyzes ADP-ribosyl-cysteine bonds (By similarity).  Specifically reverses the SirTM-mediated mono-ADP-ribosylation of GcvH-L, by releasing ADP-ribose from the target protein.  May be involved in the modulation of the response to host-derived oxidative stress.
What are the official names of this protein?
Protein-ADP-ribose hydrolase, SpyMacroD.
Protein: DEF_MYCLE
Sequence: MAIAPIRIVGDPVLHTPTAPVQVAADGSLPANLNGLISTMYDTMDAAHGVGLAANQIGYGLRVFVYDCAEDCRQTARRRGVVINPILETSEIPETMPDPDTDNEGCLSVPGESFPIGRAQWARVTGLDADGNPVTTEGTGLFARMLQHETGHLDGFLYLDYLIGRHARSAKRAIKSRHWGVPGLSWMPGEVPDPFGP
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: ISPD_XYLF2
Sequence: MSVGVWAVIPAAGRGVRFGSPVPKQYLPVVGRPLIVYTLEALAAHPAVCGLMVVVAEGDLAWSGWTELAGKPLLTCSGGVTRAASVLSGLLALPQVVHADDFVLVHDAARPNVALSDLERLLEAGCAHPVGAILAVPVRDTLKRAGSDGSIDGTEPRERLWRAFTPQLFRRSQLVRGLQVAAADGIEMTDEAMVMERQGLRPLLVECAESNFKITTPDDLVRFEFELARRV
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: TRIQK_HUMAN
Sequence: MGRKDAATIKLPVDQYRKQIGKQDYKKTKPILRATKLKAEAKKTAIGIKEVGLVLAAILALLLAFYAFFYLRLTTDVDPDLDQDED
What is the function of this protein?
May play a role in cell growth and maintenance of cell morphology.
What are the official names of this protein?
Triple QxxK/R motif-containing protein, Triple repetitive-sequence of QXXK/R protein homolog.
What is the protein family that this protein belongs to?
Belongs to the TRIQK family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: FABZ_GEOSL
Sequence: METVFDINEIMKILPHRYPFLLVDRIVEYVAGERIVGIKNVSINEPFFQGHFPGHPVMPGVLIVEAMAQVGGIYAYVTLGDEVRDKVCYFASIDNVKFRKPVVPGDQLRIEVTISGCKRGIWCFSARATVNGKLVTEAELKATFADKEKL
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_SALA4
Sequence: MQKRAIYPGTFDPITNGHLDIVTRATQMFDHVILAIAASPGKKPMFTLEERVALAQKATAHLGNVEVVGFSDLMANFARDRQANILIRGLRAVADFEYEMQLAHMNRHLMPQLESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPDNVHQALMDKLK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_SHIDS
Sequence: MNVVILDTGCANLNSVKSAIARHGYEPKVSRDPDVVLLADKLFLPGVGTAQAAMDQVRERELFDLIKACTQPVLGICLGMQLLGRRSEESNGVDLLGIIDEDVPKMTDFGLPLPHMGWNRVYPQAGNRLFQGIEDGAYFYFVHSYAMPVNPWTIAQCNYGEPFTAAVQKDNFYGVQFHPERSGAAGAKLLKNFLEM
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_EHRCJ
Sequence: MSIISIAVDAMGGDFAPEAVIGGLDFALTNLLDNKDVSFNIYGQESQVLPMLDKYKNVKEHSLFIDTPDIVLANDKPSFALRKRKSSSMWCAIESIKNGVTSGVVSSGNTGALMAISCFVLGTLPNIKRPAICCALPSKCERYFVILDLGANVDCSANSLFQFAIMGNAFAKAVLNVPNPKVALLNVGEEEVKGTDVIREAFLLLRQAESSINFCGYIEPINMLGGEVDVVVADGFCGNVVLKVAESIAYIFKSVFEKSVSSSIITKIAGLLLKSSMKRNFMKFNPKIYNGAMLVGLNGVVVKSHGNADKIAFAHAVKVAVNAARNNINAKIIHELG
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RL36_CLOBM
Sequence: MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: SCG3_XENTR
Sequence: MGPKYVFITAIIGVFWHVQGFPNPGIKQDKAVHNRELSEERPLEEQIAEADTVSRGTSKENQEMLKNDSFADELGLLMSVAEKEGDVKRSGSVRSSVGGHRGTLDDADSTKNLKPAEYFDSTKSMLDYKYEDDPDGLHQLDGTPLTAEDIVRKIATRIYEENDRGVFDKIVSKLLNLGLITESQAYTLEDEVAEVLQQLIANEAKNREKEAGDLDYAAVRSDVYDDDKQEGKMETRNKNEDRESSETKNEDSFSSKERRNELSPEEDFDDLQYFPNFNRLIKSLNSENDAKEKKTLITIMKTLIDFVKMMVKYGTITPEEGVNYLENLDAMIAVQAKNKLGKSFGSHKSILSEDKNVDESDSTKQEAAKMEKEYEALKDSTKPEPKDAEDKDKPKGKAETYLEAIRKNIEWLKEHNKEGNKGVSDNDLSKLKDFINQQADSYVEKGILDKEEANVIKRIYSSL
What is the function of this protein?
Member of the granin protein family that regulates the biogenesis of secretory granules (By similarity).  Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity).  May also play a role in angiogenesis.  Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity).
What are the official names of this protein?
Secretogranin-3, Secretogranin III, SgIII.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol- enriched lipid rafts.
Protein: ORTB_ACESD
Sequence: MSKDMSYSGVMSRRNEIMKNAIGIDYTTFESGSLSFDYEKMMRETGYTLEEMQKIQYSTGVGRTPVLELRNITALARKYAAPGKGARIFIKDEAGNPSGSFKARRAANAVYHAKKLGYKGVIAATSGNYGAAVASQAAMAGLKCIIVQECYDSKGVGQPEIIEKARKCEALGAEVVQLSVGPELFYKFLSLLEETGYFNASLYTPFGIAGVETLGYELAVEFREAYGKDPDVVVCSNAGGGNLTGTARGLIKAGAQSEVVAASVNLQGLHMASDTQFNKKSFTTSHTGFGMPFATWPDRSDVPRSAARPLRYMDRYVTVNQGEVFYITETLASLEGLEKGPAGNTALAAAFSLAQEMDKDQIIVVQETEYTGAGKHIQPQLAFARDNGIDIKFGNPKEEVAGINIILPENPGMIKAVDHEMNKLRKSLIKNALANYPDAKLDDSDIDFLVKETKSDTEFVKATIKEIKG
What is the function of this protein?
Involved in the ornithine fermentation pathway.  Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine.  It is strictly specific for AKP.
What are the official names of this protein?
2-amino-4-ketopentanoate thiolase beta subunit, AKP thiolase, AKPT.
What is the protein family that this protein belongs to?
Belongs to the threonine synthase family.
Protein: ASNA_LEIBR
Sequence: MDPTLTELLHSNLQWIFVGGKGGVGKTTTSCALATLFATTPISDAAAPDGTRPRRVLLISTDPAHNLSDAFNQRFGPQPTPVKGLEDTLAAMEVDPKNFTHGALMSSLTGANSGGSASSLSREAEADAVEQTASFARIGAVLKEAARTMPGIDEISVFAEILHYVRTLSYDLLIFDTAPTGHTLRLLALPQTLNSTFDRLMSLEGLAPMLEAASHLIGSSLGAVGGDSVSGCEVATAMPSSSSTAPGAGSAATGSSQGSWSITADEVRAKALHWRQVMEEVQDRFNDPSRTSFVCVCIAEFLSVYETERLVQELMKYNIGCDSIVVNQLVLKPSSEPPCRMCAARQKIQTKYLEQIDLLYDDFHVVKMPLLSDEVRGIPALKMFARFLQEPYNPDTHGYIDVQESC
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase ASNA1 homolog, Arsenical pump-driving ATPase homolog, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: Y2913_MYCTO
Sequence: MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAAGALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTTVLLGNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQTWSTPAEYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMAKLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLISVLRHRGRILQSAPDVDNPVSALLFFLASSRIFNRRKGVRMSMLVSADAKSMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDGIDLPVFEEFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFHDAVIVECPDKSLIGKSFGAIADERGLHPLDAFLDVLVDNGERNVRWTTIVANHRPNQLNKLAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRARDADRAGQPFLSIERAVYRLTGELAEWFGIGAGTLRQGDRADFAVIDPTHLDESVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQFRDGYGQNVKSGRYLRAGELGAALSRSA
What are the official names of this protein?
Uncharacterized protein MT2981.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. N-acyl-D-amino-acid deacylase family.
Protein: PIH1_YEAST
Sequence: MADFLLRPIKQRHRNEDKYVSVDAADGSVSKIEPIADFVIKTKLLSANGPEKLQDGRKVFINVCHSPLVPKPEVDFNARIVFPLIIQNEWEIPIITSCYRMDHDKKGQECYVWDCCINSDCSRWICDDIQLREILVEWCLESCEIRDSVVLCRDRIAFPKMKKKGAELPALEVLNDELHQDYKAKMHKIIEEEAGDPMSILRGRNDDGDDNNDPDDGTLPPLFPIENKISGAKIEEIDKNEIAHRNLKQAPAPAPAPHEQQEDVPEYEVKMKRFKGAAYKLRILIENKAPNSKPDRFSPSYNFAENILYINGKLSIPLPRDIVVNAADIKIFHIRKERTLYIYI
What is the function of this protein?
Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.
What are the official names of this protein?
Protein interacting with Hsp90 1, Nucleolar protein 17.
What is the protein family that this protein belongs to?
Belongs to the PIH1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL6_CHLTB
Sequence: MSRKARDPIVLPQGVEVSIQNDEISVKGPKGSLTQVLAKEVEIAVKGNEVFVAPAAHVVDRPGRMQGLYWALIANMVKGVHTGFEKRLEMIGVGFRAAVQGSLLDLSIGVSHPTKMPIPTGLEVSVEKNTLISIKGINKQLVGEFAACVRAKRPPEPYKGKGIRYENEYVRRKAGKAAKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ADAA_ASPNC
Sequence: MSGPTKLVFFGNEFPNDDLKALFRGLHRHGKDRRFRQLATFLEESTRVLQNEVAQLPEPLKKLVPHFENLMPLTEVDFRQGPLGAAMESALLTILELGMFIGHYEAEERVWDLSADRTTLAGLSIGLLAAAGVALSTHLAEVVQNGAECVRVSFRLGVYVHDISRKLEAPQADGSLLSWAHVVTGETASDLQEELSRYNTETGTPELLKVFISAADKTSVSVSGPPSRIRAAFRASQRLRYSKSLALPVYDGLCHAAHLYDEETIHRVLHPDGSVIPTSRPVQLALLSSRSGQPFEATTAAELFRAISTELLTGTIFLDNITAGILDRTERCADAPQCQIETYRTSLVFKGLLKALEACFPDRTISTTDLIPWVFQDYGARQPKSYADSKLAIVGMACRMPGGANDLDLFWELLAQGRDTHTTVPADRFDLETHYDPTGETENATRTPFGNFIDQPGLFDAGFFNMSPREAEQTDPMHRLALVTAYEALEMAGIVSGRTPSSNPKRIATFYGQASDDWRELNASQNIGTYAVPGGERAFANGRINYFFKFGGPSFNLDTACSSGLAAVQAACSALWAGEADTVLAGGLNIITDPDNYAGLGNGHFLSRTGQCKVWDQSADGYCRADGVGSVVIKRLEDAEADNDNILAVVLSAATNHSAEAISITHPHAGAQKENYTQVLHQAAVNPLDISYVELHGTGTQAGDAQEAESVLDIFAPRAHRRRADQPLHLGAVKSNIGHGEAAAGIASLLKVLLMYQKNEIPAHIGIPTVINPAIPTDLEQRQVYLPRTKTAWPRAAGQIRRAIVNSFGAHGGNTTLVLEDAPEKQVTVAREERSTHPVVISAKSKKSLAANVETLLAYLDENPETDLGDLSYTTCARRMHHSWRLATAVSDIPALQKFLRNAVSNDAVSQTRPIPTEAPHVVFTFTGQGAYYAGLAQGLFQALPFFRAEVRQLDHLSQRLGFPSIVPVILGEVEEGTATALVTQLSIVIVEIALARLWLLLLGIPAPHAVIGHSLGEYAALAVAGVLSTADALYLVGHRAQLIEEHCTPGSHAMLSVRATIADIERLVGTGADAPTYELSCQNTHQDTVIGGSIQDLNAIREKLEPEGIKCVNVDVPFAFHTAQMDAVRERLAKAVAAVPFKTPSVPVLSPLLGSVVFDGKSINPEYIVRATREPVRFATAIDAAQELGIVNSQTLWVDIGPHPICASFVRSLVPGARIVSSCRRNEDNFATMAKSLCTLHLAGRTPSWAEYFRPDEQAYSLLRLPKYRWNEVNYWIQYLGTWTLDKAHLKNGGSQKRTITDVPSVSSLRTSLIHQVTEETVDKTTATLKAISDIQHPDFLEAVHGHTMNNCGVATSSIWTDMAMTVGEHLYRRLVPGTDHVLMDLCDFEVQHAQVANTNSNTPQPLALEAHLDLPTRHMSLAWYDVNATTNQRADAPFATGSIKYPADPTGAAWSIEWSRITHLIQGRIEALQHLAAENKASTLSKPLAYALFKNVVDYAPRYRGMDRVVIHDHEAFSDITLTTDRHGTWHTPPHWIDSVSHLAGLVMNGSDASNTRDFFYVTPGCGSCRMTEPLIAGGKYRNYVRMFPMPDEAHMYAGDLYILREDKIIGVVEQLKFRRVPRLLMDRFFSPNKNAAAHAAPAPAPAAVPAVKKQPPTETIQPQAPKTEQKQDQLQLPNLASAAPSTANSSSSPSSSGVATPTTEQEAPVADASAVTGVAGKCLELIANETGLGVAELTADATFVQLGVDSLMSLVLSEKLRSEMGLEIKSSLFLECPTVGDLTGWLEQYC
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist (PubMed:21866960).  The decaketide backbone of TAN-1612 is synthesized by the non-reducing polyketide synthase adaA via condensation of one acetyl-CoA starter unit with 9 malonyl-CoA units.  The FAD-dependent monooxygenase adaC then performs hydroxylation at C2 while the polaketide chain is still attached to the NRPKS adaA (PubMed:21866960).  The alpha-hydroxylation step at C2 appears to be crucial for the following C18-C1 Claisen cyclization and release of the C9-hydroxyl version of TAN-1612 from the NRPKS adaA, two steps performed by the lactamase-like protein adaB (PubMed:21866960).  Finally, the O-methyltransferase adaD performs the C9 O-methylation to complete the biosynthesis of TAN-1612 (PubMed:21866960).
What are the official names of this protein?
Non-reducing polyketide synthase adaA, NRPKS adaA, 2-acetyl-2-decarboxamidoanthrotainin biosynthesis cluster protein A.
Protein: RLMN_COXBN
Sequence: MTEKINLLNLSEPELQGFIASQGQPLYRATQLLQWIHQRGVTDFSLMTDLSKPFRQQLSEASFVRVPELALERVSADGTHKWLFRLADNNKIETVFIPDRKRGTLCVSSQVGCALNCSFCATGKEGFNRNLTLAEIIGQVWLAARLLKSPYKITNVVMMGMGEPLLNYEAVVAAMHLMMHDHAYGLSKYRVTLSTSGVIPAMRRLREESPVSLAVSLHAPNDALRNVLIPLNKKYSLDQLIPLCRDYYSRGSKRCVTFEYVMIEGMNDRLIDAKQLIRLLADVPCKINLIPFNSFQGTAYRCSTESAISVFQKCLMDAGFNTRVRRTRGDDIAGACGQLAGQFHDRTGRHQRWVQKQGHDFNRPIPAIDH
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_ECO45
Sequence: MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGRRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVASILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.