PharMolix/UniProtQA huggingface dataset:
Protein: RPOA_DEHMC
Sequence: MSDLAIPTISCTESDGKYGRFVVEPLEKGFGTTMGNSLRRILLSYLDGVAITRVRIDGIQHEFCALPKAKEDTLDFLLNLKNIRVESLSGLEGILYLRASGSKVVTAADIEPSNDFEVVNPELYLLTLDSDDAVLNVELEVELGRGYRPPESAENTPIGTIPVDAIFTPIRKVNFTTEPMHVGRETSLERLVLEVWTDGTVEPATAVSRSADILVKQFASLVSHSKVVAEIEASEPVKYTIPEEKYNMPIEQLDLSVRAVNCLRHAGITTVGEVINRGTKELLTLRNFGLKSLTELEDRLKTIGLSLNPEDELFEEAENNKKKNKGIDED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: FMT_PSEPK
Sequence: MRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSAVKALAVAHDIPVFQPQTLRNADAQAELAALKPDLMVVVAYGLILPQVVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDTGGTLHDRLAEMGPPAVVQAIAGLADGSLQGEIQDDALATYAHKLNKDEARIDWTHPAVELERLIRAFNPWPVCHSTLDGESVKVLAANLSTGQGAPGEILSASKDGLVVACGDQALSLTRLQLPGGKALSFSDLFNSRREKFAAGKVLGQ
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: HSLO_DESRM
Sequence: MQDYLVRAVASDGNFRIFSARTTNTVEEARTRHNSWPVATAALGRTMTAALLMGANLKGEDTLSIRVLGDGPLGAIIVTSNAKGEVRGYVQEPQIHLPSTPEGKLAVGAAVGKGHLHITKDLGLKEPFTGSVELVSGEIAEDFAHYLTTSEQTPSAVSLGVLVDTDNSVVAAGGLILQLLPGAGEEVLEILEQNLRQLPHLSSLIKNGETPEDIIKRVTKGIEMKFLESNPVGFSCQCSRERLENLLVGIGKDEVTSMLQEQGAAEINCHFCAENYHFDKKDLQRILKRIEEKD
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP24_EBORE
Sequence: MAKATGRYNLVPPKKDMEKGVIFSDLCNFLITQTLQGWKVYWAGIEFDVSQKGMALLTRLKTNDFAPAWAMTRNLFPHLFQNPNSVIQSPIWALRVILAAGLQDQLLDHSLVEPLTGALGLISDWLLTTTSTHFNLRTRSVKDQLSLRMLSLIRSNILQFINKLDALHVVNYNGLLSSIEIGTSTHTIIITRTNMGFLVEVQEPDKSAMNSKRPGPVKFSLLHESAFKPFTRVPQSGMQSLIMEFNSLLAI
What is the function of this protein?
Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways.  Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter.  Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes.  Plays a role in assembly of viral nucleocapsid and virion budding.  May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
What are the official names of this protein?
Membrane-associated protein VP24, Reston VP24, rVP24.
What is the protein family that this protein belongs to?
Belongs to the filoviridae membrane-associated protein VP24 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein. Note=In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place (By similarity).
Protein: TOLC_VIBCH
Sequence: MKKLLPLFVSAALGTLSSAVWAENLAEIYNQAKENDPQLLSVAAQRDAAFEAVTSSRSALLPQINLTAGYNINRSDQAPRESDLLSAGINFSQELYQRSSWVSLDTAEKKARQADSQYAATQQGLILRVAKAYFEVLRAQDNLEFVRAEKAAVGRQLEQTKQRFEVGLSAITDVHDAQAQFDGVLADEVLAENSLTNSYEALREITGQEYSKLAVLDTKRFAASRTTESSEALIEKAQQQNLSLLAARISQDVARDNISLASSGHLPSLTLDGGYNYGNNSNDNAKNTSGEEYNDFKIGVNLKVPLYTGGNTTSLTKQAEFAYVAASQDLEAAYRSVVKDVRAYNNNINASIGALRAYEQAVISAKSALEATEAGFDVGTRTIVDVLDATRRLYDANKNLSNARYDYILSVLQLRQAIGTLSEQDVMDVNAGLKVAKK
What is the function of this protein?
Outer membrane channel, which is required for the function of several efflux systems (By similarity).  Required to export RtxA cytotoxin.
What are the official names of this protein?
Outer membrane protein TolC, Multidrug efflux pump subunit TolC.
What is the protein family that this protein belongs to?
Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: HD6N_ORYSJ
Sequence: MSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIV
What is the function of this protein?
The Nipponbare allele of HD6 contains a premature stop codon, resulting in a truncated non-functional product.
What are the official names of this protein?
Inactive casein kinase II subunit alpha-2, OsCKA2, Protein HEADING DATE 6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Protein: MASZ_MYCTU
Sequence: MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQALLNARDELQAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSGVDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKVRGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIEILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLAAAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVFEGIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPKMHGPAEVAFTCELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWTMTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDNNCQSILGYVVRWVDQGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVRASLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLAAQELILSGAQQPNGYTEPILHRRRREFKARAAEKPAPSDRAGDDAAR
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POTA_TREPA
Sequence: MRQTVKGCAVTIDQVSKAYGHCLAVDRATVHIRQGEFFSILGPSGCGKTTLLRIIAGFEQPDSGDLTFDHVSVLGVGANKRRSNTVFQSYALFPHLSVYENIAFPLRLKRLSKNLIRERVHEYLHLVQLDEHLHKKPHQLSGGQQQRVAIARALVCEPGVLLLDEPLSALDAKLRSNLLIELDTLHDQTGITFVFITHDQSEALSVSDRIAVMNKGKILQIGTPYEIYEQPATDFVAKFIGETNSFLSTVVSCTAIENEEFMLSLQVPELDRTLTVTADNPIDPGRRVCFTVRPEKIHISLEEPGTTSAPLNVFRGFVEEPVYAGFQSKFFVQLESGAIIQVFQQHQKYLDTGPEIAWKDTVYVSWSAHDGYVVEDIES
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NFI_THET8
Sequence: MRPPPFPKPAHPEEALALQRALAKKVRLAGSLEGVRRIAALDASHKRGRPLVAVALLYDLEKGPLHVATALLPEEALFPYVPGLLSFREAPAYLEALAALPEAPEALLVDGQGVAHPRGLGIASHLGVHLDLPSVGVAKRLLYGRPEAPLPEEKGAAVRLLAPDGRPLGYVYRSRTGVKPLYVSPGHRVGLEEALRFVRRLPTRFRLPEPLRLAHLEAGRALKALD
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_BARHE
Sequence: MLDIKWIREHPEKLDEALAKRGIEPQAERLIKLDLERRSHVAKVQSAQERRNTASKKIGQALAVCDQKMAERFRAEVEEIKVFLSSATAEEKRLTESLENALSALPNIPLDDVPEGKDESDNVVLRHFSVPTTFDFTPKEHFDLGQNLKQMDFERASRLSGTRFTVLSGALARLERALGQFMLDVHVYEHGYTEVSVPLLVRDESVYGAAQLPKFADDLFRTTDGRWLISTAEVPLTNLVNNEILEISDLPLRFSSLTPCFRSEAGSAGRDTRGMLRQHQFWKVEMVSITTAEQSLIELERMTECAEDVLKRLDLPFRTMVLSTGDMGFAARKTYDIEVWLPGQGCYREISSCSVCGDFQGRRMNARYRKEGEKTLHFVHSLNGSGTAVGRCLIAVLENYQQADGSIIIPDVLQPYMRGMRCITA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINP1_PONAB
Sequence: MLRASGCLLRTSVAPAAALAAALFSSLARCSLLEPRDLVASSLSPYFGTKTRYEDVNPLLLSGPEAPWRDPELLEGSCTPVQLVALIRHGTRYPTAKQIRKLRQLHGLLQARGSRDGGAGSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLLQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVLEYLNDLKQYWKRGYGYTINSRSSCTLFQDIFRHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKEQMHRKFRSGLIVPYASNLIFVLYHCENAKTPKEQFRVQMLLNEKVLPLAYSQETVSFYEDLRNHYKDILQSCQTSEECELARANSTSDEL
What is the function of this protein?
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6).  Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate.  May play a role in bone development (endochondral ossification).  May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity).  Through the regulation of intracellular inositol polyphosphates, may control intracellular cation homeostasis, including that of calcium and iron, hence affecting free cation availability required for neural cell signaling (By similarity).
What are the official names of this protein?
Multiple inositol polyphosphate phosphatase 1, 2,3-bisphosphoglycerate 3-phosphatase, 2,3-BPG phosphatase, Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, Ins(1,3,4,5)P(4) 3-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family. MINPP1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: PIMT_CHLP8
Sequence: MQHTDDMVQERRGMVELLRRYGIRNSRVLDAFLTVKRHLFVDGESRMFAYHDSALPIGFGQTISQPYTVAYMMELLVENCSSGKVLEIGTGSGFQAAILDALGYRVFTIECVAGLYELASARFEKLGIPVQSRLGDGTLGWPEEAPFDAIIVTAAAPHEPRELMSQLADGGVLILPLGSLASQQMTVIRRKGNRFEHEGFDHFAFVPLLGREGWPDSDE
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_BRASO
Sequence: MKLSDIADNAGARKKRMRVGRGIGSGKGKTSGRGGKGQTARSGVRIKGFEGGQMPMHRRLPKRGFNNIFALDFVEINLDRIQQAIDAKKLDAGSVINAESLVKSGALRRSKDGVRLLGRGELKAKINIEVYGASKSAIAAVEKAGGTVKILAPAKDEGEAA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ATPD_MARN8
Sequence: MAELTTLARPYAKAVFDAAQDQNAVDQWDQALAFAAQVAADQEVKNILANPGLSEQRKAELFAECFEEPLPEALRNFLLILAENKRLALLPEISALFRLYRADLEKSVHLTIDTAFDLSADEQQKLIDALSKKLERKVELETTVDQSLIGGVIVRTGDLVIDASVRGKLARMARALGS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PRMA_MARN8
Sequence: MPWIQLQIPADPDTADQLEDLLMEMGADAVSMEDAADQPLYEPDPGTTPLWSQTTVTGLFQSDRNIEQLLADIRDAWHQQTQQSLADIDVTLVEDKDWERAWMDDFHPLQFGERLWIVPSWHEAPDPDAANLLLDPGLAFGTGTHPTTALCLEWLDGQDVAGKQVTDYGCGSGILGLAALLLGADHVVGVDTDPQALEASRDNARRNGVEDSRLDLYLPGQDPDTRADIMLANILAQPLIGLAPRLAELTRPGGHLVLSGILFNQAREVMDAYEPWFVMDEPEQKEDWIRLTGRRKDG
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FORB_DICDI
Sequence: MFFKGKKKDKEKEKSHGNIGNVISVENKTGSQSNLHVEQNLSNEDLKIQFSQLLYELGVPEAKRVEMELWSNDKKWMLLVQNKDKIKENEEKMKQKGSLYETPQFYLSLLRENASIQKTISDLKVSLASNKLSWIDSFIGLSGFDEILKIFQTFQLKPEKNSIDFLILFDCVNIIKSILNSQSGVKSVMTTSHTFKVLVLCLDQSYPPELRNAVLQLTAALTLLPTVGHSYVLEAIENFKVSNREKVRFQTIIEGAKSVSNTQLHYEYLTSFMNLVNSIVNSPADLQVRIGLRSEFTALKLIELISNSKGVSEDLDTQINLFFECMEEDNDEVGAHYKEVNIRSPSEVSTKIDTLLQSHPALHHHFISIIKGLYTLASTQSDLGGSMWNILDESVGLILKDPSKESQLEKLQNENNNLKLQLSEIKLNNSNNNNNNNNSNNNNNDSNVSTPNINTGSPLLPPQQYQDLEQKLQLTQNEKNESQNKVKQLESEIKGLNSTLTGLQLKVTKLEADLLSVSVTTPPSDTNGTTSPPIEAPSSPSLGAPPPPPPPPPAPPVSGGGPPPPPPPPPPSSGGGPPPPPPPPSSGGPPPPPPPPGGMKKPGAPAVPNLPPKKSSVPSVKMVGLQWKKVNNNVIENSIWMNVKDYNLNDQFKQLEELFQVKKPTATTPTAPVGGASNVAVGGGSGSKSIVSTPTISILDPKRSQAIMIMLSRFKISFPDLSKAITNLDESKLNLEDAKSLLKFVPSSEEIELLKEEDPSCFGKPEQFLWELSKINRISEKLECFIFKQKLSTQIEELTPDINALLKGSMETKNNKSFHQILEIVLSLGNFINGGTPRGDIYGFKLDSLSGLLDCRSPSDSKVTLMTWLIQFLENKHPSLLEFHQEFTAIDEAKRVSIQNLRSEVASLKKGLTLLTNEVEKSEGASKTILSGFVGKSTDAVTLIEKQFNTALESFNSTVQFYGEDVKTSSPEEFFQHVSKFKNEFKRTIESIQKERENVQKLAARKKAAASGPSVPSASGSSINIAPKSGVSPITPTSKSSISISQKPPQSTQPSISVQQQQQQHHGDDDDDIPQNGTFMDQLMSKMKGGEAIRASRRASQYVFTQNGAGGVGAIDALNAALKNKK
What is the function of this protein?
Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
What are the official names of this protein?
Formin-B.
What is the protein family that this protein belongs to?
Belongs to the formin homology family. Diaphanous subfamily.
Protein: CLPX_DESHY
Sequence: MAKYNDEKNQLKCSFCGKTQDQVKKLVAGPGVYICDECIELCNEIIEEELNEDLGMEIGDIPKPKEIRAILDQYVIGQDEAKKALAVAVYNHYKRINLGMKIDDVELQKSNIVMLGPTGSGKTLLASTLAKVLNVPFAIADATSLTEAGYVGEDVENILLKLIQAADYDVEKAEKGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQLDTTNILFIVGGAFDGIDKIIQNRIGKKVMGFGAEIKKKSEQNIGETLRELLPADLLKFGLIPEFVGRLPVMVKLDALDEEALVRILTEPKNALVKQYEKLLELDGVALEFKEEALKAIAEEAIRRNTGARGLRAIVEEIMQNVMYDLPSRNDVTKCVVTKDVILKKEEPLLVTIDKSKKNKKEESA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SHSA5_MOUSE
Sequence: MAAPAPSLWTLLLLLLLLPPPPGAHGELCRPFGEDNSIPVFCPDFCCGSCSNQYCCSDVLRKIQWNEEMCPEPESRFSTPAEETPEHLGSALKFRSSFDSDPMSGFGATVAIGVTIFVVFIATIIICFTCSCCCLYKMCCPQRPVVTNTTTTTVVHAPYPQPQPQPVAPSYPGPTYQGYHPMPPQPGMPAAPYPTQYPPPYLAQPTGPPPYHESLAGASQPPYNPTYMDSLKTIP
What is the function of this protein?
Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
What are the official names of this protein?
Protein shisa-5, Scotin.
What is the protein family that this protein belongs to?
Belongs to the shisa family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane.
Protein: CREST_BOVIN
Sequence: MSVAFASARPRGKGEVTQQTIQKMLDENHHLIQCILDYQSKGKTAECTQYQQILHRNLVYLATIADSNQNMQSLLPAPPTQSMTLGPGGLSQSGSAQGLHSQGSLSDAIGAGLPPSSLMQAQIGNGPNHVSLQQTAQSTLPTTSMSMSGSGHGSGPGYSHSGPASQSVPLQSQGAISNYVSRANINMQSNPVSMMHQQAASSHYSAAQGGSQHYQGQSMAMMGQSGQGGGVMGQRPMAPYRPSQQGSSQQYLGQEEYYGGEQYGHGQAASEPMSQQYYPDGHGDYAYQPASYTDQSYDRSFEDSTQHYYEGGNSQYSQQQTGYQQGTAQQQTYSQQQYPNQQSYPGQQQGYGPAQGAPSQYSSYQQGQGQQYGSYRASQTGPSTQQQRPYGYEQGQYGNYQQ
What is the function of this protein?
Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons.  Recruits CREB-binding protein (CREBBP) to nuclear bodies.  Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex.  In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex.  Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex.  At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation.  The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
What are the official names of this protein?
Calcium-responsive transactivator, SS18-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the SS18 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity).
Protein: MNMG_THEP3
Sequence: MNFIAGEYDVAVVGLGHAGSEAALACARLGLKTVGFAVNLDSIALMACNPSIGGPAKAQLVREIDALGGEMAINTDKSLLQIRTLNTSKGPAVRSLRAQVDKKLYQMNMKYTLERQENLDIKQAEIVDILVEDNKVTGVVTKLGAIYKCKACIITTGTFLKGRVIIGDVSFDSGPSGLFPANQLSETLKRLGFKLMRFKTGTPARVDKRSIDFSKMEIQPGDEVITPFSYMHDKIEIEQLPCWLTYTNKRTHEIIMANIHRSPLFSGEITGVGVRYCPSIEDKVVKFPHKERHQIFIEPEGLNTYEMYVQGMSSSLPEDVQLEFLRTVPGLENVRVMRPAYAIEYDCIDPTQLKATLESKKIEGLYFAGQVNGTSGYEEAAAQGLMAGINAAMKLLNKPSVILDRSQAYIGVLIDDLVTKGTNEPYRMLTSRAEYRLLLRQDNADFRLTELGYKIGLVTEERYQKFLKKKIQLEKEMRRLLGVMIKPSEEVNNFLISKGSTPLVTGVDLYTLLKRPEIDYKSTKFLDKNRPDDILDSVAEQIDINIKYEGYIMKQLRQVEHFKALENKKIPEDIDYYQIHGLSNEAKEKLTKIRPTSIGQASRISGVSPADISVLLIYMQQLRRNKEDEEQIG
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQB_CUPTR
Sequence: MTTIRVLGSAAGGGFPQWNCNCRNCDGVRRGTVRATPRTQSSIAVCGDGPEAILVNASPDILQQLRQTPALQPARAARDTAIAAVLLMDAQIDHVTGLLMLREHRRALPLYATASVLEDLAGAFPLTRILSHYCGLQCHALPCDGMAFSVPPLDGVALTAVPLQSKAPPYSPRRHAPQPGDNIGLRIEDRHSGRSAFYAPGLGQVDDHVFAQLRRADVVLVDGTFWRDDEMQALGFSTRSAADMGHLALSGPGGMIEVLDRLPARRKILIHINNTNPVLAEDSPERAELARHGIELAYDGMEIAL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.
Protein: QUEA_ACIBY
Sequence: MQLSDFSFELPDELIARYPLETRSASRLLHLDAKGQYHDHMFTDIIDLFEEGDLLVLNDTKVMKARLKGKRATGGAIEILVERMLNHTTAYCHIKASNSPKAGAELFVGADNIPVIVRGRHENLFVVEFSQPILPVLEQYGQLPIPPYFNREAEEIDTERYQTVFHNPEKIASVAAPTASLHFDEELLAELDQKGVKKTFVTLHVGAGTFMPVRTDDITNHVMHSEWCDVPQETIDLILATKARGNKVIAVGTTATRALESAAQAHGGKIAAWTGDTQIFIYPGYEFCIVDRLITNFHLPESTLLMLVSALSNRENILAAYEHAVKDRYRFFSYGDAMLIDKLEV
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FDL32_ARATH
Sequence: MSTKRGVTSQDSISLLPDDLLCRILSNLPTKVAVRTSVLSKRWKRFSLSVPLLEFNVSEFHGYYEFARVVHGFLDTSRETCIHKLKLAFEKKQHDRSYLTQWIHNAVKRKVQHLDIGRWSYLGQELIPHSLYTCETLVSLRLHNVSLPDFDHVSLPRLKTMHLIDNIYPNDALLENLISSCPVLEDLNVSRDVENIVKVLRVRSLSLKSLILALDGDRYGDIEDDSWEVVIDAPRLSYLSLRDDQSKSFVLSSVTSPAKVDIDVTFDVVRSVLKNFLLTRSVVRNFFTRLSSVRDMTMSGTTLKVLSRYMRHEPLPQFPNMIQFYAVFCNSDLEKLPNFLESCPNLKSLVLELEVFKKNDLLILSSSIPKCLRSSLEHVEIHTPISGAEAEMKLVKYFLENSAVLKKFTLQLGCKRMDEESIIFKELLRFRRCSASCEVVVEV
What are the official names of this protein?
Putative F-box/FBD/LRR-repeat protein At5g22670.
Protein: TIG_STAAC
Sequence: MTATWEKKEGNEGLLTVTVPAEKVNKALDQAFKKVVKQINVPGFRKGKVPRPIFEQRFGVEALYQDAIDILLPDAYGEAIDETDIKPVAQPEVSVTQIEKGKDFIFEATVTVEPEVKLGDYKGLEIEKQETELSDDELQEAIDHSLGHLAEMVVKEDGVVENGDTVNIDFSGSVDGEEFEGGQAEGYDLEIGSGSFIPGFEEQLEGMKVDEEKDVVVTFPEEYHAEELAGKEATFKTKVNEIKFKEVPELTDEIANELDAEANTVDEYKENLRKRLAEQKATDAENVEKEEAITKATDNTTIDIPEAMVNTELDRMVSEFAQRIQQQGLDLQTYFQISGQDETQLREQMKDDAEQRVKTNLTLTAIAEAEKIEATDEDIDKELEKMSKQFNISVEDIKNTLGNTDIIKNDVRIQKVIDLLRDNAKFVEGTKED
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: AROQ_SALTO
Sequence: MRVYVLNGPNLGRLGTRQPEVYGTTTYADLVELCQQTGRELGLEVVIRQTDAEQELLGWLHEAADLGACVVLNPAAWSHYSIAVRDACALLRAPLVEVHLSNIHAREEFRHHSVVSAVATGVICGLGVDGYRLALHHLAARAR
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.