PharMolix/UniProtQA huggingface dataset:
Protein: COBQ_HALSA
Sequence: MTAGEDCRTILVAGTASHVGKSTVAAGLCRLLADRGLSVAPFKAQNMSNNARAVPVADGAPPAADPWGEIGVSQYVQARAARTAASTDHNPVLLKPRGDAESQLVVDGRAVGHYSAGSYYESHWADARDAAAAAHARLAADNDVVVAEGAGSIAELNLHDRDLANLETARFADATILLVVDIERGGAFASLHGTLALLPDDIRDRVAGAVITKFRGDRSLLDPGITEIEARTGVPVLGVIPHDDPGLPAEDSVSLPDPSERVVDGGQDGVPDAASVTVAVPHLPHISNFTDLAPLARTPGVRVAYQPLDAPLAAADAVVLPGTKNTVDDLRAAREAGLGRALRAFDGPIVGLCGGYQMLGDRITDAATESTADDLGAVDGVGVLPVETAFQPDKRVEAVTRELADCGALGGATGAVTGYEIHMGRTTVPDGVPQPVGPASAARGRVLGTYLHGLFGNDAARRGFRDAVFAAAGVEQPAPADTPDQSPSDAAAALVDAHVDLDPLGVPPAPDA
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Probable cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: RISB_STRA5
Sequence: MTIIEGQLVANEMKIGIVVSRFNELITSKLLSGAVDGLLRHGVSEEDIDIVWVPGAFEIPYMARKMALYKDYDAIICLGVVIKGSTDHYDYVCNEVTKGIGHLNSQSDIPHIFGVLTTDNIEQAIERAGTKAGNKGYDCALSAIEMVNLDKKLRER
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: SPT4_NEUCR
Sequence: MSENYVAPGQQRYLRACMVCSIVMTYARFRDEGCPNCEDFLHLQGSPDQIDSCTSQVFEGIITIANPQKSWVAKWQRLDGYVKGVYATKVSGQLPDDVRTTLEDDGIQYIPRDGSATEAD
What is the function of this protein?
The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing.  This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
What are the official names of this protein?
Transcription elongation factor spt4, Chromatin elongation factor spt4, Transcription elongation factor 2.
What is the protein family that this protein belongs to?
Belongs to the SPT4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Centromere and heterochromatin.
Protein: GPDA_MYCTO
Sequence: MAGIASTVAVMGAGAWGTALAKVLADAGGEVTLWARRAEVADQINTTRYNPDYLPGALLPPSIHATADAEEALGGASTVLLGVPAQTMRANLERWAPLLPEGATLVSLAKGIELGTLMRMSQVIISVTGAEPAQVAVISGPNLASEIAECQPAATVVACSDSGRAVALQRALNSGYFRPYTNADVVGTEIGGACKNIIALACGMAVGIGLGENTAAAIITRGLAEIIRLGTALGANGATLAGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAGKACHVVEGVTSCESVLALASSYDVEMPLTDAVHRVCHKGLSVDEAITLLLGRRTKPE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CR2AA_BACTK
Sequence: MNNVLNSGRTTICDAYNVVAHDPFSFEHKSLDTIQKEWMEWKRTDHSLYVAPVVGTVSSFLLKKVGSLIGKRILSELWGIIFPSGSTNLMQDILRETEQFLNQRLNTDTLARVNAELIGLQANIREFNQQVDNFLNPTQNPVPLSITSSVNTMQQLFLNRLPQFQIQGYQLLLLPLFAQAANMHLSFIRDVILNADEWGISAATLRTYRDYLRNYTRDYSNYCINTYQTAFRGLNTRLHDMLEFRTYMFLNVFEYVSIWSLFKYQSLMVSSGANLYASGSGPQQTQSFTAQNWPFLYSLFQVNSNYILSGISGTRLSITFPNIGGLPGSTTTHSLNSARVNYSGGVSSGLIGATNLNHNFNCSTVLPPLSTPFVRSWLDSGTDREGVATSTNWQTESFQTTLSLRCGAFSARGNSNYFPDYFIRNISGVPLVIRNEDLTRPLHYNQIRNIESPSGTPGGARAYLVSVHNRKNNIYAANENGTMIHLAPEDYTGFTISPIHATQVNNQTRTFISEKFGNQGDSLRFEQSNTTARYTLRGNGNSYNLYLRVSSIGNSTIRVTINGRVYTVSNVNTTTNNDGVNDNGARFSDINIGNIVASDNTNVTLDINVTLNSGTPFDLMNIMFVPTNLPPLY
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of both dipteran (Aedes aegypti) and lepidopteran (Manduca sexta) larvae.
What are the official names of this protein?
Pesticidal crystal protein Cry2Aa, 71 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryIIA(a), Mosquito factor, P2 crystal protein.
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: CHS7_MEDSA
Sequence: ITHLIVCTTSVDMPGADYQLTKLLGLRPYVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEVTAVTFRGPSDTHLDSLVGQALFGDGAAALIVGSDPVPEIEKPIFEMVWTAQTIAPDSEGAIDGHLREAGLTFHLLKDVPGIVSKNINKALVEAFEPLGISDYNSIFWIAHPGGPAILDQVEQKLALKPEKMKATREVLSEYGNMSSACVLFILDEMRKKSAQDGLKTTGEGLEWGVLFGFGPGLTIETVVLRSVTI
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase, Naringenin-chalcone synthase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: PUR9_LEIXX
Sequence: MNGPRHDTSLFRERDVVPIRRALISVSDKTGLLDLAASLADAGVEIVSTGSTAQTIREAGHTVTDVASVTGFPESLDGRVKTLHPAIHSGLLADLRLASHEEQLKDLGIEPFELVVVNLYPFVETVASGAVDDDVVEQIDIGGPAMVRASAKNHANVAIVVSPADYAGLAAAVAAGGTTWGQRRELAARAFAHTAAYDGAVAAWFAGEAPDLSAVAERFEVRAEWGQPLRYGENAHQAAALYADPAGCGIAQASQHGGKEMSYNNYVDADAALRSAYDFAEPAVAIVKHANPCGIAVAGDIAEAHRKAHECDPVSAYGGVIAANRTVTLAMAETVRGIFTEVLIAPGYEPGALELLKTKKNLRILELPVGYARSLTEFRQISGGVLVQDTDRFDEFDSSGWTLVAGAEADAVTRADLEFTWKACRAVKSNAILLAKDGASVGVGMGQVNRVDSCTLAVSRAAERAVGAVAASDAFFPFADGPEILIAAGVAAIVQPGGSIRDEEVIASATAAGVTMYFTGERHFFH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: 5NTC_BOVIN
Sequence: MTTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTVCDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEE
What is the function of this protein?
Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:9371705, PubMed:8031149).  In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:9371705, PubMed:8031149).  Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:9371705, PubMed:8031149).  Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:9371705, PubMed:8031149).  Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:9371705, PubMed:8031149).
What are the official names of this protein?
Cytosolic purine 5'-nucleotidase, Cytosolic IMP/GMP-specific 5'-nucleotidase, Cytosolic nucleoside phosphotransferase 5'N.
What is the protein family that this protein belongs to?
Belongs to the 5'(3')-deoxyribonucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HSXH2_RHILO
Sequence: MSDVSFHDLSSLDATQRSSLLKRAEADLSVFVEKVRPIIQAVKDEGDAALIRFARELDKANVAEGGLQVSEAEFDAAFDKVEKDVVESIGFGIDNIRRFHEEQKPETMWLKEVRPGAYAGDRYTPIASVALYVPRGKGAFPSVTMMTSVPAVIAGVPQIAIVTPPTSDGSVDAATLVAARLAGVHTVYKCGGAQAVAAVAYGTETVKPALKIVGPGSPWVVAAKSELSSIINTGLPAGPSEAIIFADDSVDGGLAALDLLIEAEHGPDSSAYLVTHSRKVAEAALAALPQHWSRMTEQRVEFSRAVLTGKRGGIVLTASLEDSYRFINDYAPEHLEILSKEPFAHLGHITEAAEILMGPHTPVTLANFVLGPNAVLPTSRWARTYGPLSVTDFVKRSSVGYVTSAAYPELAKHARRLARYEGFSSHENAVSEIRDRYLAG
What are the official names of this protein?
Histidinol dehydrogenase homolog 2.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: MYCD_MOUSE
Sequence: MTLLGSEHSLLIRRKFRSVLQLRLQQRRTQEQLANQGLIPPLKGPTEFHDPRKQLDSAKTEDSLRRKGRNRSDRASLVTMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPMDSSVKEAIKGTEVSLSKAADAFAFEDDSSRDGLSPDQARSEDPQGSTGSTPDIKSTEAPLDTIQDLTPGSESDKNDAASQPGNQSDPGKQVLGPLSTPIPVHTAVKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFLQLQILSQQQQQQQQQQQQQQQQQQQQQRFSYPGMHQTHLKEPNEQMARNPNPSSTPLSNTPLSPVKNSISGQTGVSSLKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALVDRLRPFQDCAGNPVPNFGDITTVTFPVTPNTLPSYQSSPTGFYHFGSTSSSPPISPASSDLSAAGSLPDTFTDASPGFGLHASPVPACTDESLLSSLNGGSGPSEPDGLDSEKDKMLVEKQKVINQLTWKLRQEQRQVEELRMQLQKQKSSCSDQKPLPFLATTIKQEDVSSCPFAPQQASGKGQGHSSDSPPPACETAQLLPHCVESSGQTHVLSSTFLSPQCSPQHSPLGGLKSPQHISLPPSPNNHYFLASSSGAQRENHGVSSPSSSQGCAQMTGLQSSDKVGPTFSIPSPTFSKSSSAVSDITQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKIPKIPGSSCSPTAIPPKPSASFEQASSGGQMAFDHYANDSDEHLEVLLNSHSPIGKVSDVTLLKIGSEEPPFDSIMDGFPGKAAEDLFSAHELLPGPLSPMHAQLSPPSVDSSGLQLSFTESPWETMEWLDLTPPSSTPGFSNLTSSGPSIFNIDFLDVTDLNLNSPMDLHLQQW
What is the function of this protein?
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence.  Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes.  Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis).  Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription.  Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.
What are the official names of this protein?
Myocardin, Basic SAP coiled-coil transcription activator 2, SRF cofactor protein.
What are the subcellular locations of this protein?
Nucleus speckle. Note=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei.
Protein: SWNN_METRA
Sequence: MVVVAVAGGTGGVGRTVLDAIAKSGQHQAIVLSRTTSVPTAVDEPKRFAVDYNSVEQMKKILQENNVQVVVSALLLVDEAVAQSQINLIRAAAQSGTVTKFIPSEYYIDFHAPIPYVSLQSILSRQRFSLFSTSGADLFTNFQLEAEAELSRHAQLTWTLIRVGIFLDHLTMPHNPKTTYITPFWVFVDIDHEQCVFPGDGSQPLVLTHSQDLAAYIERLVGLPAENWPRESVVASNKLLVKDLESLVNKVTGKKFKVAYDSVECIHKGRITQLPSNTAVFQDPAKGEMFRDVEHQVMLSMLSRAHDLPGKNLAELFPEVETTDIEDFFRSGWTLKQSRAP
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of swainsonine (SW), a cytotoxic fungal alkaloid and a potential cancer therapy drug (PubMed:28381497, PubMed:32786262).  Swainsonine production occurs via a multibranched pathway and is dispensable for fungal colonization of plants and infection of insect hosts (PubMed:32786262).  The first step of swainsonine biosynthesis is the production of the precursor pipecolic acid (PA) via conversion of L-lysine (Lys) to 1-piperideine-6-carboxylate (P6C) by the aminotransferase swnA, the latter being further reduced to PA by the reductase swnR (PubMed:32786262).  PA can be converted from lysine by both the SW biosynthetic cluster and the unclustered genes such as lysine cyclodeaminase (PubMed:32786262).  The PKS-NRPS hybrid synthetase swnK uptakes and condensates PA and malonyl-CoA with and without skipping of the ketoreductase (KR) domain in order to produce 3 intermediates, 1-oxoindolizidine, (1S)-1-hydroxyindolizin, and (1R)-1-hydroxyindolizine; with the transisomer (1S)-1-hydroxyindolizin being predominant (PubMed:32786262).  The terminal thioester reductase (TE) domain of swnK is involved in reduction of the thioester bond to release the intermediate aldehydes (PubMed:32786262).  The oxidoreductase swnN could contribute to the reduction of 1-oxoindolizidine to (1S)-1-hydroxyindolizin and (1R)-1-hydroxyindolizine, contributing to the major route of SW production (Probable).  The dioxygenase swnH2 would be responsible for the oxidization of (1R)-1-hydroxyindolizine into (1R,2S)-1,2-dihydroxyindolizine and of (1S)-1-hydroxyindolizin to yield both (1R,2S)-1,2-dihydroxyindolizine and (1S,2S)-1,2-dihydroxyindolizine (PubMed:32786262).  The dioxygenase swnH1 then performs the conversion of the 1,2-dihydroxyindolizine epimers to SW (PubMed:32786262).
What are the official names of this protein?
Oxidoreductase swnN, Swainsonine biosynthesis gene cluster protein N.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: BIOF_PASMU
Sequence: MIRYYQQQLADLKAQNQFRQLPQLIHRGRFIQREDNTMLNMSSNDYLGLANNEALRQAFFTQYQDQLPALTSSSSRLLTGSFPIYDELESLMAQAFGRETALLFNSGYHANIGILPALADKKTLIVADKLVHASMIDGIRLAQCEFVRFRHHDYAHLEQILQKNDRTFERIIVVTESVFSMDGDCADLTQLVALKQRYPQVMLYVDEAHAIGVLGEKGLGLAEQQGCINQIDILVGTFGKALGSMGAYVICDQVIRDYLVNKMRPLIFSTALPPFNVAWTHFVFQQLPHLQAERAHLAQLSQHLRQAIVDIFQVPMPSESCIVPYILGDNELTVRTAQRLQQQGYYCLPIRPPTVPKGTSRIRFSLTADMQVAEVEQFIACLQELAE
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: Y3404_BRUSU
Sequence: MTETPLLSVRGLAKHYQTRSATLKILDNVSFDIARGEVVGLVGESGSGKTTIGRSVLRLIEPTAGQIMFDGADVATLSAREMRRQRRRMQYIFQDPFASLSPRMTIGEILMEGLNIQGIGTKAERLERARKALEQVELPPDTINRYAHEFSGGQRQRIGIARALTLEPDFIVADEPVSALDVSIQAQVVNLLRDLQQRLGLTMLFISHDLAVVEYICDRVIVLYLGRIMEIASSEDLYARPQHPYTRALLSAIPSPDPDARTERQILRGDIPSPANPPSGCVFRTRCPMAIDACATTVPQLREVRPGHFKACIRDNI
What is the function of this protein?
Probably part of an ABC transporter complex that could be involved in peptide import.  Probably responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative peptide import ATP-binding protein BRA0404/BS1330_II0401.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KLH12_RAT
Sequence: MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPDLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGDNEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGIIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVASMGTQRCDAGVCVLREK
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.  The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B).  The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export.  As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3.  The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins.
What are the official names of this protein?
Kelch-like protein 12, CUL3-interacting protein 1.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle.
Protein: RL15_STRPB
Sequence: MKLHELKAAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGGGVRLGFEGGQTPLFRRIPKRGFTNINTKEYALVNLDQLNVFDDGTEVTPAILKDAGIVRAEKSGVKVLGNGELTKKLTVKAAKFSKSAEAAIIAKGGSIEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: CYSD_BAUCH
Sequence: MEQKHLTHLQQLEAESIHILREVVAEFRNPVMMYSIGKDSSVMLHLARKAFYPGKLPFPLLHVDTGWKFREMYHFRDHTAKAYGFELLVHKNLEGQAMGINPFVHGSAKHTNIMKTESLKQAMNKYNFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINQGESIRVFPLSNWTEIEIWQYIFLENIDIVPLYFAKERPILERNGMLIMIDDDRIDLQFGETVGQRMVRFRTLGCWPLTGAVESTAQTLPDIIKEMLISATSERQGRVIDTDQSSSMEMKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: YCEI_SALA4
Sequence: MKKNLLGFTFASLLFTTGSAVAAEYKIDKEGQHAFVNFRIQHLGYSWLYGTFKDFDGTFTFDEKNPSADKVNVTINTNSVDTNHAERDKHLRSAEFLNVAKFPQATFTSTSVKKEGDELDITGNLTLNGVTKPVTLEAKLMGQGDDPWGGKRAGFEAEGKIKLKDFNITTDLGPASQEVELIISVEGVQQK
What are the official names of this protein?
Protein YceI.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: RDRP_RCNMV
Sequence: MGFINLSLFDVDKLMVWVSKFNPGKILSAICNLGIDCWNRFRKWFFGLNFDAHMWAVDAFIPLMPHYTEQMERVVDDFCSETPESKLEDCLELDTSVNEFFDEEVYKKDEEGVMKLQRSAARKHIKRVRPGMMQAAIKAVETRIRNRHTIFGDDMGKVDEAAVRATASDICGEFKINEHHTNALVYAAAYLAMTPDQRSIDSVKLAYNPKSQARRTLVSAIRENKAVAGFKSLEDFLGGPLSFPVEDAPYPILGIPEIRVAEKRASRVMKSKRVVGLPAVSAGLKVCVHQTSLHNMIVSLERRVFRVKNSAGELVVPPKPIQNAFDSISYFREEWLRKLSHKGQILKSSLADVVACYSSEKRKLYQKAADSLEKKPVQWRDSKVQAFIKVEKLECDTKDPVPRTIQPRSKRYNLAIGQYLRLNEKKMLDSIDDVFKEKTVLSGLDNRAQGRAIAHKWRKYQNPIGIGLDASRFDQHCSVDALKFEQTFYKACFPGDQQLETLLKWQLSNTGSALLPTGELVRYRTKGCRMSGDINTGLGNKILMCSMVHAFLKETGVRASLANNGDDCVLFCEKGDYEQINRNLEQWFLCRGFEMTVEKPVDVLEKVAFCRSQPVCIATQWAMVRQLGSLSRDCFSTQDWLNPKTFKDAMNALGQCNGIINDGVPIHMAQAKLMHRIGGNRKFNLDALHKQMEYSWRDRLGKRTNLLWSEVEDATRLSYFRAFGIEPYIQRIVEEYFSQVEITCEGRSTNVLPTHYSRIHKDLIKAR
What is the function of this protein?
RNA-dependent RNA polymerase, made of isoforms p88 and p27, plays an essential role in the replication of the bipartite viral genome composed of RNA-1 and RNA-2.  Replicase proteins p88 and p27 interact together and selectively recruit viral replication templates as well as other essential components into intracellular membranes for the assembly of the 480 kDa viral replicase complex.  Mechanistically, isoform protein p27 binds to the Y-shaped RNA element (YRE) located in the 3' UTR of RNA2 via a direct RNA-protein interaction and to RNA1 in a translation-coupled manner.  This RNA-binding activity allows RNA2 recruitment to host membranes.  The viral replicase complex synthesizes the dsRNA genome from the genomic ssRNA(+).  It recognizes internal subgenomic promoters on the negative-sense RNA to transcribe the 3' co-terminal subgenomic RNAs that will generate the capsid and movement proteins.  In addition, the viral replication process requires the trigger of an intracellular ROS burst mediated by p27 recruitment of the host ROS-generating machinery.  The viral replicase complex also acts as a suppressor of RNA-mediated gene silencing, known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.
What are the official names of this protein?
RNA-directed RNA polymerase, Protein p88.
What is the protein family that this protein belongs to?
Belongs to the tombusviridae RNA polymerase family.
What are the subcellular locations of this protein?
[Isoform RNA-directed RNA polymerase p88]: Host endoplasmic reticulum membrane. SUBCELLULAR LOCATION: [Isoform protein p27]: Host endoplasmic reticulum membrane. Note=Associates with intracellular membranes via membrane-association domain in the N-terminal region. Membrane association is essential for RNA replication complex formation.
Protein: YCCT_ECO27
Sequence: MKTGIVTTLIALCLPVSVFATTLRLSTDVDLLVLDGKKVSSSLLRGADSIELDNGPHQLVFRVEKTIHLSNSEERLYISPPLVVSFNTQLINQVNFRLPRLENEREANHFDAAPRLELLDGDATPIPVKLDILAITSTAKTIDYEVEVERYNKSAKRASLPQFATMMADDSTLLSGVSELDAIPPQSQVLTEQRLKYWFKLADPQTRNTFLQWAEKQPSS
What are the official names of this protein?
UPF0319 protein YccT.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: KDPA_HALSA
Sequence: MASPPPIVEYAVFFTILAVLVFVAGEYLAWVYREQANSDHRPPGYLSWFERLDEIFTPIENGLYRLSGINPRREMTWKGYLKAVLVFNVCIWVLLFVVLMFQDALPMNFVGVGGESWDLAFHTASSFTSNTNQQHYSGETLSVFTHTFGIGIAMFLTPATGLALMPAFARAFTNKEDPRLGNFYENVVRGLVRFLLPISLLIAIILMAEGSVQTILGGQLTANTFTMGIQNIRIGPHAGIEAIKMFGTNGGGINAANAATAFENPTPLSNLVLTLAMPIGTFSAIYAWGAWVGNRSHGVAIVAAFFVIYMALTGVAVVGETGTNAGMVVTGNGLHVDQTVGNMEGKETRFGPTASAIWGLSTTGTTNGGVNSMHNSWTALGAFSLLFAFATNNISNGVGTGLLNILMFVILTAFIGALMIGRRPQYLGKKLEWQEMRYVFVVILVLPILVLIPQAAAVVYQGAIDSMNNPGFRGFSEVLYEFFSASANNGSGFEGLGDGTLFFNLVNGVQVLLARYVPITAQLAIAGYLANKKVSPESKGSLDTDTPAFVGLLIGVIIIVSALVFLPALVFGPIGELLSGGI
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUB1_DESAN
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGTMIKVKTLTGKEIEIDIEPTDTIDRVKERVEEKEGIPPVQQRLIYAGKQLADDKTAKDYNIEGGSVLHLVLALRGGY
What is the function of this protein?
Probably function as a stable post-translational protein modifier.  May be involved during cold acclimation.
What are the official names of this protein?
Ubiquitin-NEDD8-like protein RUB1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus.