PharMolix/UniProtQA huggingface dataset:
Protein: PYRB_STRPQ
Sequence: MSVVNNRVALTNLVSMEALTTEEVLGLINRGSEYKAGKVVISDHQKDLVANLFFENSTRTHKSFEVAEKKLGLTVLDFNADASAVNKGESLYDTVLTMSALGTDICVIRHPEDDYYKELVESPTITASIVNGGDGSGQHPSQCLLDLLTIYEEFGRFEGLKIAIAGDLTHSRVAKSNMQILKRLGAELYFYGPEEWYSEAFNAYGTYIAIDQIIKELDVLMLLRVQHERHDGHQSFSKEGYHQAFGLTQERYQQLKDSAIIMHPAPVNRDVEIADSLVEAPKARIVSQMANGVFVRMAIIEAILNGRNKNS
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: CLPX_SHESA
Sequence: MGDNKNNGDSGKLLYCSFCGKSQHEVRKLIAGPSVYVCDECVELCNDIIREEIKEISPKRDNDKLPTPHELRAHLDDYVIGQDRAKKVLSVAVYNHYKRLRNSSPKDGVELGKSNILLIGPTGSGKTLLAETLARSLNVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLEKVIEQRAHVGSGIGFGAQVKGEKDKATISQTLSQVEPEDLVKYGLIPEFIGRLPVVATLTELDEEALVQILSEPKNALTKQYNALFEMEGVELEFREDALKAIAHKAMSRKTGARGLRSIVEGILLDTMYDIPSIEGVVKAVVDESVVNGESAPILIYERNEAQAASGEQ
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: PPK5_ELLSS
Sequence: FGETSGETKGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, EllSp-Capa-PK, FXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ECM33_SCHPO
Sequence: MLFKSFALTLLFAAARVQAASNCSSGPYNISAQGTLDELNSCTVLNGDLYISDAGNSGITTLTVNGIESVQGDVVVSDGQYLTSLSFPSLKNVSGAFNVNNMIRMNNLATPELTSVGSLNLAVLPNLQELQFNAGLSDSDSVVIDDTQLQAIDGISLDSVTTFQVTNNRYIQEITMEGLESAQNIQISANSKGVSVNFSKLSNVTTATFDGISNVFIGNLKSAAGNLYFSNTTLDNISVPYLTEIGQSFAVLYSPELTSLNFPNLTTVGGGFVINDTGLTSIDGFPVISEIGGGLVLLGNFSSIDMPDLSDVKGALTVETKATNFTCPWSNDDSVIKGDDFTCQGSVATISATSSYDLSSTVSATSGSATSATGSATTTSYSSDSSASSSSSSSHESSAASNGFTAGALVLGSLLVAALAM
What is the function of this protein?
Involved in the negative feedback regulation of pmk1 cell integrity signaling and is linked to cellular calcium signaling.
What are the official names of this protein?
Cell wall protein ecm33.
What is the protein family that this protein belongs to?
Belongs to the SPS2 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Secreted, cell wall.
Protein: MNMC_SHEHH
Sequence: MTVSKILKQVINRKTTRQIVIAQLGLGSLASLKQLIIEQLQLISDHRVTLKIFSQIEPNLHTFISDTELAELFSSKPNTSLSLAAIEGCQRIIVNDGKLKIDFHLGSYAQQLQQLPIVSSGFIDGWNMADNLAQEQLDSALFWQMAKLAHNDCLFCLEPTLTPEAQQQSLLLAEQVGLYSELPLKNDDTLFQERAALRAQSHQQQAPFPICPAALTPVENDIGIAIIGGGVASACLALSLAERDQRVTLFCEDDALAQAASGNKQGAIYPLLTPDNNTLSQYFQQAYLFSLQRLKTLAARGHKIDFDLCGVVHTGHDERSRKRVAKITHGHNWEPNIALAIAAEQASNIAGVKLDDGGLFYPQGGWVSPQDFTRAAFNQAQAISDASLKLNTQITGIHSKDNVWYLSSKTERFGPFKALIVANGKSITQYPQTQYLQATGFRGQVSHVPSRAKLSKLSAVLCAHGYMTPSNNDLHCLGASYVKNAADTRYSPSEQVENLHKIQHSYIGQDWIEDIDVSGHSARVDVRMVTRDHAPMMGPVPNLDAILALYQQHQLTPESRQFWQTHAAPTHKNLYVLGGLGSRGLCSGPLAAEALAAQICGEPMPISLDFVSLLNPNRMWMRKLLKGKALEMSGKS
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIM15_CHICK
Sequence: MFDVKAWAVYIVEWAAKDPYGFLTTVILVLTPLFIISAALSWKLAKMIETREREQKKKRKRQENIVKAKRAKKD
What are the official names of this protein?
Small integral membrane protein 15.
What is the protein family that this protein belongs to?
Belongs to the SMIM15 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: UBP8_YEAST
Sequence: MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMCLQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDDVCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN
What is the function of this protein?
Functions as histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK.  SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes.  At the promoters, SAGA is required for recruitment of the basal transcription machinery.  It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8).  SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac).  SAGA interacts with DNA via upstream activating sequences (UASs).  SLIK is proposed to have partly overlapping functions with SAGA.  It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.  Together with SGF11, is required for histone H2B deubiquitination.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 8, Deubiquitinating enzyme 8, Ubiquitin thioesterase 8, Ubiquitin-specific-processing protease 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. UBP8 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PNP_CHLAB
Sequence: MTFETISVTLEEGKTLVFETGKIARQANGAVLARMQETWVFSSVCAANLEEAVDFLPLRVDYQEKFSSIGKTLGGFIKREGRPTEREILTSRLIDRSMRPSLPNRLMQDIQILSYVWSYDGVTLPDPIAICGVSAALAISDIPQTSIVAGVRVGFVNNRWVVNPTKAEMDVSRMELVLAGTENAILMIEGHCDFFTEEQVIEAIEFGHKHIVTICKALKDWQKHIGKEKNTSGIVSLPEEVQSAVNTFVEGKFVDLLKIKEKKAFEAASKQLENEVIEQLQEENEVFTAFNIKIAFKQAKSNFIRGLIREQGLRSDGRSVTTIRPISIDTSFLPRTHGSCLFTRGETQTMAVCTLGSEAMAQRYEDLNGEGLAKFYLQYFFPPFSVGEVGRIGSPGRREIGHGKLAEKALSHTLPDPMKFPYTIRIESNITESNGSSSMASVCGGCLALMDAGVPIKTPIAGIAMGLILEDDHVTILSDISGLEDHLGDMDFKVAGNTEGITAFQMDIKVEGITPDIMRAALAQAKEGRQDILETMKQALAAPKTDLSQYAPRIETMQIKPNKIATVIGPGGKQIRQIIEEAGVQIDINDSGLVSISASSPQAIEKAKSIIEGLVGEVEVGKIYEGRVTSVVPFGAFVEILPGKEGLCHISEFSKQRIDNVGDFVKQGDTLTVKLLSINEKGQYKLSHKATLSE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPBM_ARATH
Sequence: MASRRVLSSLLRSSSGRSAAKLGNRNPRLPSPSPARHAAPCSYLLGRVAEYATSSPASSAAPSSAPAKDEGKKTYDYGGKGAIGRVCQVIGAIVDVRFEDQEGLPPIMTSLEVQDHPTRLVLEVSHHLGQNVVRTIAMDGTEGLVRGRKVLNTGAPITVPVGRATLGRIMNVLGEPIDERGEIKTEHYLPIHRDAPALVDLATGQEILATGIKVVDLLAPYQRGGKIGLFGGAGVGKTVLIMELINNVAKAHGGFSVFAGVGERTREGNDLYREMIESGVIKLGEKQSESKCALVYGQMNEPPGARARVGLTGLTVAEYFRDAEGQDVLLFIDNIFRFTQANSEVSALLGRIPSAVGYQPTLASDLGALQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRQISELGIYPAVDPLDSTSRMLSPHILGEEHYNTARGVQKVLQNYKNLQDIIAILGMDELSEDDKLTVARARKIQRFLSQPFHVAEIFTGAPGKYVDLKENINSFQGLLDGKYDDLSEQSFYMVGGIDEVVAKAEKIAKESAA
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta-1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Protein: BLA5_KLEPN
Sequence: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
What is the function of this protein?
SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime.  SHV-5 causes particularly high levels of resistance to aztreonam and ceftazidime.
What are the official names of this protein?
Beta-lactamase SHV-5.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: LEPA_CUPPJ
Sequence: MDHIRNFSIIAHIDHGKSTLADRIIQLCGGLSDREMEAQVLDSMDIEKERGITIKAQTAALTYKARDGKVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIELGVEVVPVLNKIDLPQADPANAIQEIEDVIGIDAHDATPCSAKTGQGVEDVIEALIAKVPPPKGDASAPLQALIIDSWFDNYVGVVMLVRVVNGTLRPKDKALLMATGAQHLVEQVGVFSPKSVQRDSLTAGQVGFVIAGIKELKAAKVGDTITTLPRKAEAPLPGFKEVKPQVFAGLYPVEANQYEALRESLEKLRLNDASLMFEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDMDLITTAPTVVYQVQMRDGTMVTVENPAKMPDPSRIEAILEPIVTVNLYMPQEYVGSVITLCTQKRGSQINMSYHGKQVQLTYEIPMAEIVMDFFDRLKSVSRGYASMDYEFKEYRPSDVVKVDILINSDKVDALSVIVHRSNSQYRGREVAAKMREIIPRQMYDVAIQAAIGSNIIARENVKALRKNVLAKCYGGDISRKKKLLEKQKAGKKRMKQVGTVEIPQEAFLAILQVDDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: THIO_GEOCY
Sequence: MVNFLKTKADFDQALKDAGDKLVVIDFTASWCGPCQRIAPKYVEMAKEFPDVIFYKVDVDENDETAEAEKIQAMPTFKFYKSGKALSDYVQGANEAGLREKIKKNK
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PARVA_RAT
Sequence: MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSEFQEEGMNAINLPLSPISFELDPEDTMLEENEVRTMVDPNSRNDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINEALKLPPRSIKWNVDSVHAKNLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE
What is the function of this protein?
Plays a role in sarcomere organization and in smooth muscle cell contraction.  Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract.  Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity).  Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis.  Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.
What are the official names of this protein?
Alpha-parvin, Actopaxin.
What is the protein family that this protein belongs to?
Belongs to the parvin family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions.
Protein: PURT_CUPMC
Sequence: MTTLGTPLSPSATKVMLLGSGELGKEVLIALQRLGVETIAVDRYENAPGQQVAHHARTITMSDGEQLKALIEAERPDLVVPEIEAIATPMLEALEAAGVVRVIPTARAARLTMDREGIRRLAAETLGLPTSPYKFCDSLEELQAAIDGGIGYPCVVKPVMSSSGKGQSKIDGPADVKAAWDYAMAGGRVSHGRVIVEGFIDFDYEITLLTVRAVGANGEVETHFCEPIGHVQVAGDYVESWQPHPMHPKALETSQHIARAVTADLGGQGLFGVELFVKGEQVWFSEVSPRPHDTGMVTMITQWQNEFELHARAILGLPVSTALRAPGASAVIYGGVEAEGIVFDGVDEALRVPQTELRLFGKPESFTKRRMGVALAYAEDVDTARERAKEAAGKVKPRKA
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: TRMB_CHLPN
Sequence: MKPQDLSPPFLWKERRPCIQDGVLYVPRHYFEHQNFSTSYHQEFFQNHTSIACELCSGNGDWVVAQAQKDPQVLWIAVEQRFDRVRKIWSKMINHQIQNLRIVCGTAETFFQYYVPDQFLQRLVVNFPDPWPKMRHRKHRLLQPSFVQEISRSLQDSAVFALATDDKTYLLESIEALQTHLAPRMETPYYIKMTDTYGNSWFENLWRTKGQEIFYTEFIKKAGI
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: COX3_CYPCA
Sequence: MAHQAHAYHMVDPSPWPLTGAIAALLMTSGLAIWFHFHSTTLMTLGLILLLLTMYQWWRDIIREGTFQGHHTPPVQKGLRYGMILFITSEVFFFLGFFWAFYHSSLAPTPELGGCWPPTGITPLDPFEVPLLNTAVLLASGVTVTWAHHSIMEGERKQAIQSLALTILLGLYFTALQAMEYYEAPFTIADGVYGSTFFVATGFHGLHVIIGSTFLAVCLLRQIQYHFTSEHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ERG20_CANAL
Sequence: MSDKLAARERFLDVFEDLVEELKQILVSYNMPQEAIEWFVRSLNYNTPGGKLNRGLSVVDTFAILNNTTSDKLNDTEYKKVALLGWAIELLQAYFLVADDMMDQSKTRRGQPCWYLVEGVNNIAINDSFMLEGAIYILLKKHFRQDPYYVDLLDLFHEVTFQTELGQLLDLITADEEIVDLDKFSLEKHSFIVIFKTAYYSFYLPVALAMYMSGINDEKDLKQVRDILIPLGEYFQIQDDYLDCFGTPEQIGKIGTDIKDNKCSWVINQALLIATPEQRQLLDNNYGKKDDESEQKCKDLFKQLGIEKIYHDYEESIVAKLRKQIDQIDESRGLKKDVLTAFLGKVYKRSK
What is the function of this protein?
Farnesyl pyrophosphate synthase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:14653518).  ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:14653518).  The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.  Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate.  5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8.  The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate.  The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).  Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).
What are the official names of this protein?
Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: RL16_THISH
Sequence: MLQPKRTKFRKQFTGKNRGLAFSGGKVSFGEYALRAQDRGRLTARQIEAARRAMTRHIKRGGKIWIRVFPDVPVTKKPLEVRMGKGKGNVEYWVCKVQPGRILYEMEGVSEEIAREAFKLAAAKLPIKTQFVTRTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: HIS6_TRIV2
Sequence: MLSKRILPCLDVKAGRVVKGVNFVDLKDAGDPVELAKVYNDAGADELVFLDITATHEDRDTIIDVVYRTAEQVFIPLTVGGGIQSLENVKALLRAGADKVSINSAAVRDPELIDRASDRFGNQCIVVAIDARRRVDPSNPGWDVYVRGGRENTGLDALSWAKEVEKRGAGELLVTSMDADGTQAGYDLELTRAIAESVEIPVIASGGAGNCEHIYTALTEGKAEAALLASLLHYGQLSVAEIKNYLRDCQVPVRLYA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_AROAE
Sequence: MSGNSLGKLFCVTSFGESHGPAIGCVVDGCPPGMPISTQEIQVELDRRKPGTSRHVTQRREPDEVEILSGVFEGVTTGTPIALLIRNQDQRSRDYGNIAETFRPGHADYAYWQKYGIRDHRGGGRSSARETAVRVAAGAIARKWLNQQYGVVIRGFMSQLGPIEIPFVDWDEVGRNPFFAPNASIVPALEDYMDELRKSGDSVGARIDVVASGVPVGWGEPVYDRLDADIAYAMMGINAVKGVEIGAGFSSVAQRGTEHSDEMTPEGFLSNNAGGVLGGISTGQDILVSMAVKPTSSIRLDRRSIDKQGDAVVINTHGRHDPCVGIRATPIAEAMLAIVLMDHALRHRAQCGDVSCATPKLARLAPSGVQRVPAPPR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: VRAA_STAHJ
Sequence: MLEIIKRLEYYAKVQPQSIALQIDDEIVNYENLYQKICDCTLNSPKFKLGCRVALLNDSPIVNITNYFVVLMMDGVPCFLDNKWSRDTIDKLIEHFHIEYVMTAIGKFKRTTSFGTYEKYISEQLKVDDLLHIGFTSGTTGLPKAYYRNEPSWIASYVENEKLIYNYEKALAAPGPLAHSLSLYTCIYALYSGRTFIGQRQFDAKRFISILNEQHSNIALFLVPTMLHQLLNVDTTITHIKSIFCSGAKLSESLFKTVSQQFKNANIIEFFGTSEASFITYNFNQTSPTNSVGQVFPNVSIKLEAQDNRKIGLLKVQSNMIYSGYVDVGVVQPHSWIETGDYAYIQNNQLYLVSRKSDRLIIGGKNIYPNVIEQQVKSLDGIEEAVVVGEPHRRFGEIAVLIYVGNQELDYTTLRRYLRQTLSRYEIPSKLVRVKDLPFTNSGKVARNTVQTLYLEGAFKV
What are the official names of this protein?
Putative long chain fatty acid-CoA ligase VraA, Acyl-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: STK4_SQUAC
Sequence: MEEVQRRQHPHPRRSLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDLIRIRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNNEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGISAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWTDEFTDFVKQCLVKNPEQRAAATQLLQHPFIKNAKPVSILRDLITDMMEIKLKRQEEQQRDLDQDDEENSEEDDMDSGTMVRASAEDTGTMRAASTLSDGARTMIEHDSSTLDSQMGTMVINSGEDEEDGTMKRKEETIQQSKPSFLEYFEQKEKENQANSHSNRNAQALQNSSDNWKVPQDGDFESLKSWSVEELQRRLASLDPTMEQEIEEIRQRYQAKRQPILDAIDAKKRWQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz.  Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.
What are the official names of this protein?
Serine/threonine-protein kinase 3/4, STE20-like kinase MST1/2, sMST1/2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between nucleus and cytoplasm.