PharMolix/UniProtQA huggingface dataset:
Protein: LEU1_METJA
Sequence: MIIYREENEIIKKALENLNIPDRVYIFDTTLRDGEQTPGVSLTPEEKIDIAIKLDDLGVDVIEAGFPVSSLGEQEAIKKICSLNLDAEICGLARAVKKDIDVAIDCGVDRIHTFIATSPLHRKYKLKKSKEEIIDIAVDAIEYIKEHGIRVEFSAEDATRTEIDYLIEVYKKAVDAGADIINVPDTVGVMIPRAMYYLINELKKEIKVPISVHCHNDFGLAVANSLAAVEAGAEQVHCTINGLGERGGNAALEEVVMSLMSIYGVKTNIKTQKLYEISQLVSKYTEIKVQPNKAIVGENAFAHESGIHAHGVLAHALTYEPIPPELVGQKRKIILGKHTGTHAIEAKLKELGIEVGKDINKDQFDEIVKRIKALGDKGKRVTDRDVEAIVEDVVGKLAKKDRVVELEQIAVMTGNRVIPTASVALKIEEEIKKSSAIGVGPVDAAVKAIQKAIGEKIKLKEYHINAITGGTDALAEVIVTLEGYGREITTKAASEDIVRASVEAVIDGINKILAKREK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Protein: Y1230_OCEIH
Sequence: MKYGIAIFPSKTIQDQANALRKRYDPRYSLIPPHLTLKESFEADEETLSETVEELRKIAKETEPFHIQINKVSTFEPVTNTIYFKVEPIQQLNDLHTKLHEGKFDDNQTHPFVPHITIAQDLEHDEFSDILGRLQMEGFNLEDYVDRFQLLYQLDNESWTVYQTFVLGRD
What are the official names of this protein?
Putative phosphoesterase OB1230.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. YjcG family.
Protein: HO2_SYNY3
Sequence: MTNLAQKLRYGTQQSHTLAENTAYMKCFLKGIVEREPFRQLLANLYYLYSALEAALRQHRDNEIISAIYFPELNRTDKLAEDLTYYYGPNWQQIIQPTPCAKIYVDRLKTIAASEPELLIAHCYTRYLGDLSGGQSLKNIIRSALQLPEGEGTAMYEFDSLPTPGDRRQFKEIYRDVLNSLPLDEATINRIVEEANYAFSLNREVMHDLEDLIKAAIGEHTFDLLTRQDRPGSTEARSTAGHPITLMVGE
What is the function of this protein?
Catalyzes the opening of the heme ring with the release of iron.  Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae.
What are the official names of this protein?
Heme oxygenase 2.
What is the protein family that this protein belongs to?
Belongs to the heme oxygenase family.
Protein: RSGA_GEOSW
Sequence: MAEGKIIKALSGFYYVLSEGKVFQCRGRGVFRKQKITPLVGDHVEFQATSETEGYIMNIRERKNWLVRPPIANVEQAILVFSAVEPDFSTRLLDRFLVLVESKHIRPIIVVNKMDLVDDQTKPTMEQYIRDYRQIGYDVIETSTITKLGVEQLLSYLEGHISVFAGQSGVGKSSLLNALRPDLQLKTNDISTHLGRGKHTTRHVELLEIGGGLVADTPGFSALELDDIELEELPLYFPEFCERSEECKFRGCLHIAEPKCAVREAVESGKIPSYRYENYISFVEEIKERKPRY
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAP47_DROME
Sequence: MFSGLTNQFTSLVGAVKGGAGDEDVPAPTGDAPAAAPAASTSVEATASSAVDPEAAAAAGGEGLEGEEAGKRLPKSASLVDSLVSEATGWLGSAKGWLGNASIPSMPAMPSMPSMPAMPAMPSIPSIPGLRKGAGADGAEGAEGAVAGEGGAAASGAVSGGEDDDKSRYISATEGADSHPASGGGTPTGDEGQIGQGKGDEVKITTKVTQQAKHFGSFLSSAISKAGSKIKETVKDNTILDSFNKEQEAFIKGQGGVGNGAAPWIGHANEAKIKEEILGLSQDRRNFVRAPPAGVDFEFSYDTAYPTAIAIMAEDKALETMRFELVPKIITEENFWRNYFYRVSLIIQAAELGTLGADGVGQASSGEDANEVATKEKKSKTAEPAKGDSSVKAIAEQPKAVIEPEAQECDVQAAKSKAKAKAQAGKELGQKISESEFVSDDFQASSESDLAEIQDGMRKLGIDSMTQQALAATDEEQWEKDLEAELKDYEVVDEGGTGGDGGGGRRKGRKAGEDDTEADEDEPTISNLRTRSTNNDWEEYADLIEDTDDLK
What are the official names of this protein?
Synapse-associated protein of 47 kDa.
Protein: DDL_SYNC1
Sequence: MQRQELQQKKIAVLMGGLSAEREVSLRTGKAISQALTRCGYEVTDIDAGRDLAQQLEKTGVEVAFIALHGRFGEDGTVQGLLELADIPYTGSGVLASSLAMDKVATKKMLCYHGIATPGFAVMRRGQKICGTLPDYPLVVKPAREGSTIGISIVHDEQELAAGLEEAFRHDDLVLVEQFIAGAEVTVGVLDGQPLPIIQVVPKGGFYDYQSKYTPGQTEYLLPAPLPETLYGALQDSAVRVFEAIGCCGAARVDFMVTDTGFYCLEVNTIPGMTETSLLPKAANAVGMSFDELVERILAGASLRK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_STRR6
Sequence: MKQLSSAQVRQMWLDFWATKGHSVEPSVSLVPVNDPTLLWINSGVATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEIGAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPHKNIDTGAGLERLVAVIQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKLGINEPFLYKLVPTVGKIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQDVFKLYDTYGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNETLQNITVESVFNYNTSQLSSKLVAIVADNAEVGAVSEGTASLIFAETSFYAEMGGQVADYGQILDESGKIVATVTNVQKAPNGQALHTVEVLAPLALNQEYTLAIDSNRRHRVMKNHTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIWEALEVKTVETDIDTAKEMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVDNTSEIGLFKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAIAATLKAPQVKEVPHKVEGLQEQLRQLQKENAELKEKAAAAAAGDIFKDVKEVNGHRYIASQVSVSDAGALRTFADNWKQKDYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGSNQPKIQELLDAVAGKL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNT1B_KLULA
Sequence: MLKRKVRYLLLIVVVFTGIILSVEAIMRFQLNKNVDYYLKFFDKHKDNIENMYDPLNIKQIPYSTIDQLYTKRQSEAEPIDWDKFAYVNYITDFEYLCNTLIQFRKLNDSGSKAKLLALVTDTLVNKSKENKEVEALLNKIKSVSDRVAVTEVGSVIQPNDHTPWSKSLTKLAIFNLTDYERIIYMDNDAIIHDKMDELFFLPSYVKFAAPISYWFVTADDLRTVSTDTKKLFKTNKLDPIEKKLASRVKNSLEIYNHLPNLPQHFYSKSMNFIIDIDGFQKSDNKVNFATHLMVIKPDVTMANDIRDNILPRYLKAKEEYDTDLINEELYNFKELIYYQFKIFRKIQYLFKPSVLILPYTKYGLLTKSIDDKRQKDLLKNAILGYERKEKDDLIQDAKFIHFSDYPLSKPWFYSNADDIQCSKKYSISDENCQLWKSLYKEYLESRAICQVN
What is the function of this protein?
N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.
What are the official names of this protein?
Glucose N-acetyltransferase 1-B, N-acetylglucosaminyltransferase B.
What is the protein family that this protein belongs to?
Belongs to the GNT1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein. Vacuole membrane; Single-pass type II membrane protein.
Protein: RL37A_DROME
Sequence: MAKRTKKVGIVGKYGTRYGASLRKMVKKMEITQHSKYTCSFCGKDSMKRAVVGIWSCKRCKRTVAGGAWVYSTTAAASVRSAVRRLRETKEQ
What are the official names of this protein?
60S ribosomal protein L37a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
Protein: CYB_PSENI
Sequence: MINLRKTHPLMKIINHSFIDLPTPSNISAWWNFGSLLGMCLMIQILTGLFLAMHYTSDTMTAFSSVAHICRDVNYGWLLRNLHANGASMFFMCLFLHVGRGIYYGSYLYKETWNIGVILLLAVMATAFVGYLLPWGQMSFWGATVITNLLSAIPYIGQTLVEWVWGGFAVDKATLTRFFAFHFILPFIITALATVHLLFLHETGSNNPLGINPDSDKIPFHPYYTIKDALGLMLLLLMLLLLALFSPDLLGDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLIIPLLHTANQRSMMFRPMSQTLFWILTANLITLTWIGGQPVEQPFIIIGQLASMLYFLLILVLMPLAGMFENYMLKPKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BTG3_HUMAN
Sequence: MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTLILQEKYKNHWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVCCRYGEKNNAFIVASFENKDENKDEISRKVTRALDKVTSDYHSGSSSSDEETSKEMEVKPSSVTAAASPVYQISELIFPPLPMWHPLPRKKPGMYRGNGHQNHYPPPVPFGYPNQGRKNKPYRPIPVTWVPPPGMHCDRNHWINPHMLAPH
What is the function of this protein?
Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.
What are the official names of this protein?
Protein BTG3, Abundant in neuroepithelium area protein, BTG family member 3, Protein Tob5.
What is the protein family that this protein belongs to?
Belongs to the BTG family.
Protein: HMGN1_MOUSE
Sequence: MPKRKVSADGAAKAEPKRRSARLSAKPAPAKVDAKPKKAAGKDKASDKKVQIKGKRGAKGKQADVADQQTTELPAENGETENQSPASEEEKEAKSD
What is the function of this protein?
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer.  May be involved in the process which maintains transcribable genes in a unique chromatin conformation.  Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.
What are the official names of this protein?
Non-histone chromosomal protein HMG-14, High mobility group nucleosome-binding domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the HMGN family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.
Protein: RSMC_YERPN
Sequence: MSALTPASEVILRHSDEFIARHVLFAGDLQDALPAQFDAAGVRVHTNQYHHWQLLSNTLEENVQFGLLATAETLAACDTLIYYWPKSKQEAQFQLANLLSILPVGTDIFVVGENRSGVRSAEEMLADFAQLAKIDSARRCGLYHGRLDKQPEFDADAWWESYQVGGVTVKTLPGVFSRDSLDSGSHLLLSTFNEPFKGSVLDVGCGAGVLASVLAQQSPKIKWTLSDVSAAAIEASRATLAVNNIEAQVIASNVYSDIKGRFEMIISNPPFHDGIQTSLTAAEMLIRGATAHLHVGGKLRIVANSFLPYPALLDAAFGSHEVLAQNGRFKVYQATVGRPPRDPKKKR
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_STRU0
Sequence: MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKDYTPQEISAMILQYLKGYAEDYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGMDKTDKDEKILVFDLGGGTFDVSILELGDGVFDVLATAGDNKLGGDDFDQKIIDYLVEEFKKENGIDLSQDKMALQRLKDAAEKAKKDLSGVTQTQISLPFITAGAAGPLHLEVSLTRAKFDDLTRDLVERTKVPVRRALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIERNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQHIVIKSNDGLSEEEIERMMKDAEANAEADAKRKEEVDLKNEVDQAIFTTEKTIKETEGKGFDTERDAAQAALDELKAAQESGNADDMKAKLEALNEKAQALAVKIYEQAAAAQQAAQGAEGAQSSDSANNDDVVDGEFTEK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: NPRE_BREBE
Sequence: MKKSYLATSLTLSIAVGVSGFTSVPAFAKTKIDYHKQWDTPQYIGEVWEPEGAKGDDVVWSYLEKYKDEFRIQGNVEDHFEIVNEARNKETDTKHYRLQEVYNGIPIYGFQQTVHIDADGNVTSFLGQFIPDLDSNKQLKKKPKLNEQKAVKQAIKDVEGEVGEKPDFIQDPEAKLYIYVHEDESYLAYAVELNFLDPEPGRWMYFIDAHSGDVINKYNMLDHVTATGKGVLGDTKQFETTKQGSTYMLKDTTRGKGIETYTANNRTSLPGTLMTDSDNYWTDGAAVDAHAHAQKTYDYFRNVHNRNSYDGNGAVIRSTVHYSTRYNNAFWNGSQMVYGDGDGTTFLPLSGGLDVVAHELTHAVTERTAGLVYQNESGALNESMSDIFGAMVDNDDWLMGEDIYTPGRSGDALRSLQDPAAYGDPDHYSKRYTGSQDNGGVHTNSGINNKAAYLLAEGGTHYGVRVNGIGRTDTAKIYYHALTHYLTPYSNFSAMRRAAVLSATDLFGANSRQVQAVNAAYDAVGVK
What is the function of this protein?
Extracellular zinc metalloprotease.
What are the official names of this protein?
Bacillolysin, Neutral protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase M4 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HSLU1_TRYB2
Sequence: MMRRVTSSLPSALKLGRSLGPNVRFSGGAAAVEASPAIPPNSSSGKTLVRNMKPRELMQELDNYIIGQTEAKKAVAVALRNRWRRHQVDAAIREEISPKNILMIGPTGVGKTEIARRLAKLVDAPFIKVEATKFTEVGFHGRDVESIIEDLYKASLTQTKQNIMRRHEETARQKAENRILKALAGVSDGFREHLRSGALDDIEVIVELQEKKEKPKNSGTNEGVFISLEIPSSIGGQRPQTVKKVMKIKDAIPAVLQEELDKIVDTEDVSAEALRACEEDGIVVIDEIDKIVTASGGYKGHQASAEGVQQDLLPLVEGTTVSTKGNVQIKTDKILFICSGAFHSVKPSDMLAELQGRLPIRVELKPLTKEDFHRIITEPRYNLIKQHVMMMKTEGVDLVFTDDALWEIASIAAHINSTVQNIGARRLITITEKVVEEVSFDGPDRKGETFVIDAAYVRNSVESMMKKVDIKKFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity).  The HslVU protease complex functions in mitochondrial DNA replication by regulating DNA helicase PIF2 protein levels.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU1, Mitochondrial proteasome-like protease HslVU ATPase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix, kinetoplast. Note=Associated with kinetoplast DNA (kDNA).
Protein: ALBU1_TRASC
Sequence: DAEHKSEIVHRFNDLKEEKFKGAALITFAQFLHKKPEEEA
What is the function of this protein?
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs.  Its main function is the regulation of the colloidal osmotic pressure of blood.
What are the official names of this protein?
67 kDa serum albumin, Alb-1.
What is the protein family that this protein belongs to?
Belongs to the ALB/AFP/VDB family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSA1_MACFA
Sequence: MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHRKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPAQPADEPAEKADEPMEH
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit alpha type-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: ESSA_STAAE
Sequence: MLMNSVIALTFLTASSNNGGLNIDVQQEEEKRINNDLNQYDTTLFNKDSKEVNDAIAKQKKERQQQIKNDMFQNQASHSTRLNETKKVLFSKSNLEKTSESDKSPYIQNKQEKKIFPYILMSVGAFLTLGFVIFSIHKGRRTKNESARKSNI
What is the function of this protein?
Component of the ESAT-6 secretion system (Ess) (Probable).  Required for the secretion of EsxA and EsxB (PubMed:15657139).
What are the official names of this protein?
ESAT-6 secretion machinery protein EssA.
What is the protein family that this protein belongs to?
Belongs to the EssA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ATPB_SHEDO
Sequence: MSTGTVVQVIGAVVDVEFPQDAVPQIYDALKITGEGACKGLVLEVQQQLGGGVVRTIAMGSSDGLRRGLEVVNTGSPISVPVGVATLGRIMNVLGEPIDECGEIGEEERYVIHRSAPSYEDQSSSTELLETGIKVIDLVCPFAKGGKVGLFGGAGVGKTVNMMELINNIAKAHSGLSVFAGVGERTREGNDFYYEMKDSGVLDKVAMVYGQMNEPPGNRLRVALSGLTMAEKFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKSGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIASLGIYPAVDPLDSTSRQLDPQVVGQEHYDVANGVQTVLQRYKELKDIIAILGMDELSDEDKTAVARARKIERFLSQPFHVAEVFTGSPGKYVSLKDTIRGFKGLLEGEFDHIPEQAFYMVGTIDEAVEKANKKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SIR4_HUMAN
Sequence: MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC
What is the function of this protein?
Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase (PubMed:16959573, PubMed:17715127, PubMed:24052263, PubMed:25525879).  Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications (PubMed:24052263, PubMed:25525879).  Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879).  Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity (PubMed:16959573, PubMed:17715127).  Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127).  In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation (PubMed:23663782).  Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782).  Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity).  Does not seem to deacetylate PC (PubMed:23438705).  Controls fatty acid oxidation by inhibiting PPARA transcriptional activation (PubMed:24043310).  Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310).  Down-regulates insulin secretion (PubMed:17715127).
What are the official names of this protein?
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial, NAD-dependent ADP-ribosyltransferase sirtuin-4, NAD-dependent protein biotinylase sirtuin-4, NAD-dependent protein deacetylase sirtuin-4, Regulatory protein SIR2 homolog 4, SIR2-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class II subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RNC_LISIN
Sequence: MNQWEELQESVGFDFQNVELLQQAFTHSSYVNEHRRENVKDNERLEFLGDAVLELTVSDYLFNKYPDMAEGHMTKMRAAIVCEPSLVEFAEAVHFSKYVRLGKGEEKAGGRTRPALLADVFESFIGALYLDNGIDKVVKFLERVIFPKIDAGAYLQTVDYKTQLQEIVQRDRDVLIEYDILGETGPAHNKAFDAQVIVNGQVLGKGSGRTKKQAEQSAAQFAINQLTHR
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDXH_NANEQ
Sequence: MVVLGQKFPEVEVQTTHGRMRLPDHYRGKWFVLFSHPADFTPVCTTEFVEFARNYDKFKAMNTELIGLSIDQVFSHIKWIEWIKEKFNVEIPFPVIADDQGELARMLGMISPYKGTNTVRAVFIVDPEGYIRAMLYYPQETGRNIPEILRLVEALQTADKYGVATPANWHVDRYEFKPSSIVGNDVIIPPASSLEEKKDREERAKKGEIECFDWWFCHKKLE
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Peroxiredoxin, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SESQ2_MOUSE
Sequence: MKLNKRSVAHYALSDSPADHTGFLRSWGGPGSPPTPSGTGRRYWFVLKGNLLFSFETRESRVPLSLVVLEGCTVELAEAPVPEEFAFAIRFDAPGVRPHLLAADGQAAQEAWVKALSRASFGYMRLVVRELESQLQDARQSLALHRCASQRAVASCSKSQAPDHRAPDPENGHFLPRDRSSIGTVEERGIRPIGRDLTEWELQGPASLLLSMGQSPVSPESSCFSTLHDWYGKEIMELRRGWQQRAKGSQTENKSQNRP
What is the function of this protein?
Plays a role in endocytic trafficking.  Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
What are the official names of this protein?
Sesquipedalian-2, Ses2, 27 kDa inositol polyphosphate phosphatase interacting protein B, IPIP27B, PH domain-containing endocytic trafficking adaptor 2.
What is the protein family that this protein belongs to?
Belongs to the sesquipedalian family.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.
Protein: Y260_CORDI
Sequence: MTQPDMSQILAQAQQMQAKLQEAQREILATTVTGTAGNGLVSIDMQGNGMVSSVTIDPKVVDADDVETLQDLLVGAFAEAHEKLGTLAEQKMGPLSQGFDGLGGMF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein DIP0260.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ATP6_EHRRW
Sequence: MSANPLDQFRISTIFKLPDIGEYNIDFTNASLFMVLSTFLISLSCYVGLRKESVIPNPLQSIIEIIYDFIVSTIESNVGKEGLQYVPLVFTIFTFILVCNLLGILPLGFTVTSHIAVTFAISMIVFISVTFIGFKHQGTHFLHILLPQGTPMWLAPMMVLIELFAYCARPVSLSIRLAANMIAGHTIIKVIAGFVINMNIFLTPLPIAFIIILIGFEIFVAILQAYIFTVLTCVYLSDAVNKH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.