PharMolix/UniProtQA huggingface dataset:
Protein: PHEX_HUMAN
Sequence: MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW
What is the function of this protein?
Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (PubMed:9593714, PubMed:15664000, PubMed:18162525, PubMed:18597632).  Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632).  Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632).  Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18597632, PubMed:18162525).  Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505).
What are the official names of this protein?
Phosphate-regulating neutral endopeptidase PHEX, Metalloendopeptidase homolog PEX, Vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein, HYP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M13 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: RL9_PARUW
Sequence: MAQLLLIKDVEALGRSGEIVNVKPGFARNFLLPQSLAVIADKNTLRMQERLKAEREKRAIADKKESEAVAMQIEGMTLVQVVKVDQEGHMYGSVTVAEIVHLIQDHAKIELEKKDIQLKHPIKTTGVHSLVVKLKEGVTANFNLKVMSEEGYRTSLEEQKA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: IF122_DANRE
Sequence: MRAVPTWIDKVHDRDKVEQCIYDLAFRPDGSQLIVAAGNRVLVYDTADGTLIQPLKGHKDTVYCVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSGDFGLWSPEQKSVSKHKVSSKITCCGWTNDGQYLALGMMNGVVSIRNKNGEEKVKIERPGGSSSPVWSIAWNPSKDEHNDILAVADWGQKLSFYQLSGKQIGKDRSLTFDPCCVSFFSKGEYMVLCGSDRQAALYTRDGVRLGSIAEQNAWVWTCRVKPDSNYVVVGCQDGTIAFFQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCRELVKKIAIYRSRLAIQLPEKILIYELLSDDSADMHYRVKEKICRRFECNLLVVCSQHIILCQEKRLQCLSFTALRQREWLMESLIRYIKVIGGPAGREGLLVGLKNGAILKIFVDNPFPITLLKQNTSVRCLDMSSNRSRLAVVDEHNTCLVYDIHTRELLFQEPNANSVAWNTQCEDMLCFSGGGFLNIKACSFPVHQQKLQGFVVGYNGSRIFCLHVYSMAAVEVPQSAPMYQYLERRMFQQAYNIACLGVTDSDWRDLATEALEGLDFHTAKKAFIRIRDLRYLELISSIEERKKRGETDNQLFLADVFAYQGKFHEAAKLYRRSGQDGRALSMYTDLRMFDYAKDFLGSADPKDTKLLMKKQADWAKNSREPRAAAEMYLSAGEHLKAIQIIGEHGWVDMLIDVGRRLDKAERAALSRCAVFLQQLQQHGYAAELYSKMGDLRALLQLHVHATHWDEAFSLVEKHPQFRDDVYVPYAQWLAEHDRFEEAQRAFHKAGRQAEAVRVLEQLTHNAVVESRFSDASYYYWMLSMQCLDIAREDSEQKQEMLKKFHSFQHLAELYHVYHSVHRYMSEPFSSNMPEILFNISRFLFHNLSTHTPMGISKVDTLYALAKQSKLLGAYKVSRHAFEKLQSLKIPARYQDSVELSSLTVRSKPYRDNEDLIPMCYRCSTNNPLLNNQGNSCINCRQPFIFSASSYEVLPLVEFYLDQGISDEEAVSLIDLEVPRVEKNKSWQEMSSGESQCLKLEDGPDDPEDDPFTAKLSFEQGGSVFVPVRVSRAVLRSMSRRDVLIKRWPAPLSWQYYRSLLPDVSITMCPSCFQMFHSEDYELLVLQHSCCPFCRRPIDESC
What is the function of this protein?
Required for cilia formation during embryonal development.  Acts as a negative regulator of Shh signaling.
What are the official names of this protein?
Intraflagellar transport protein 122 homolog.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.
Protein: MGSA_GEOSW
Sequence: MKIALIAHDKKKADMIEFVTAYQPILEQHELYATGTTGLRIQEATGLKVHRFQSGPYGGDQEIGAMIARNEMDMVIFFRDPLTAQPHEPDVSALIRLCDVYSVPLATNMGTAEILIKGLERGDFAWRNIVRGRKGEINGL
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: RL10_BUCAI
Sequence: MALSIHDKKIIVSKINKISNTALSAVTADLQGVCVNKINELRKSGREVGVKMSIVQNTLLSLAIKNTVFECLKKKLKGSTFIAYSMIHPGSGARLFKEFSKKNTQFKITGAAFEGKLLSILEINQLADMPTYKEAIIKLLLTWKMLIAGKLIYTLSAIKQKKETS
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: YOHJ_ECODH
Sequence: MSKTLNIIWQYLRAFVLIYACLYAGIFIASLLPVTIPGSIIGMLILFVLLALQILPAKWVNPGCYVLIRYMALLFVPIGVGVMQYFDLLRAQFGPVVVSCAVSTLVVFLVVSWSSQLVHGERKVVGQKGSEE
What are the official names of this protein?
UPF0299 membrane protein YohJ.
What is the protein family that this protein belongs to?
Belongs to the UPF0299 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SRR_HUMAN
Sequence: MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
What is the function of this protein?
Catalyzes the synthesis of D-serine from L-serine.  D-serine is a key coagonist with glutamate at NMDA receptors.  Has dehydratase activity towards both L-serine and D-serine.
What are the official names of this protein?
Serine racemase, D-serine ammonia-lyase, D-serine dehydratase, L-serine ammonia-lyase, L-serine dehydratase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: NEUAH_CAMJE
Sequence: MAEILCTICARGGSKGVKNKNIRKINKLEMIAYSIIQAQNSKLFKHIVISTDSDEIASVAQKYGAEVFFKREAHLANDRTAKLPVMRDALLRSEEHFKTCFETLIDLDASAPLRSSLDIKKAYESFVENDNSNLITAVPARRNPYFNLVEIQNNKVVKSKEGNFTTRQSAPKCYDMNASIYIFKRDYLLENDSVFGKNTGLFVMDESTAFDIDSELDFKIVEFLISLKNLSPKDF
What is the function of this protein?
Involved in biosynthesis of legionaminic acid (5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr.  Catalyzes the conversion of N,N'-diacetyllegionaminic acid (Leg5Ac7Ac) and CTP into CMP-N,N'-diacetyllegionaminic acid (CMP-Leg5Ac7Ac).
What are the official names of this protein?
CMP-N,N'-diacetyllegionaminic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CMP-NeuNAc synthase family.
Protein: ATP23_DANRE
Sequence: MAQSGAKAADLSREPPGEQKPSPSSRQNEEDLGYNLYPERGSRLKKSTVEESLFTFKHKCQLMLQFAMDTSPYAKLLLGAMKSSGCTVFKDRHFSCEDCDGTVSGGFDAATSQIVLCQNNIHQQAHMNRVVTHELIHAFDHCRAQVDWFSNYRHLACSEIRAANLSGDCSFINEFSRFNFGLRKHHQECVRGRALRSILAVRRVSREEAERVVDEVFDSCFNDHAPFGRIPHSKKDAKFAHRDFENRDRYYANL
What are the official names of this protein?
Mitochondrial inner membrane protease ATP23 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M76 family.
Protein: GUF1_ORYSJ
Sequence: MAGAAALRRSARRVVLPGAYALSRALQHPERLLSSQASPDRGGVLGSELGLYPPERVRNFSIIAHVDHGKSTLADRLLELTGTIKKGHGQPQYLDKLQVERERGITVKAQTATMFYRHANNQLPASDQPDAPSYLLNLIDTPGHVDFSYEVSRSLAACQGALLVVDAAQGVQAQTIANFYLAFESNLSIIPVINKIDQPTADPDNVKAQLKRLFDIDPSEALLTSAKTGQGLSQVLPAVIERIPSPPGKCDSPVRMLLLDSYYDEYKGVICHVAVVDGALHKGDKIASAATGRTYEVLDVGIMHPELTPTGVLYTGQVGYVISGMRSTKEARIGDTLHQAKSIVEPLPGFKPARHMVFSGLYPADGSDFDALSHAIEKLTCNDASVSVTKETSTALGMGFRCGFLGLLHMDVFHQRLEQEHGAQVISTIPTVPYIFEYGDGSKVQVENPAALASNPGKRIAACWEPTVIATIIIPSEYVGPVIMLCSERRGEQQEYTFIDAQRALLKYRLPLREIIVDFYNELKSITSGYATFDYEDSEYQQSDLVKMDILLNGQPVDAMATIVHNQKAQRVGRELVDKLKKFIERQMFEITIQAAVGSKVIARETLSAMRKNVLAKCYGGDITRKKKLLEKQKEGKKRMKRVGSVDIPQEAFHELLKVSNSK
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1 homolog, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1 homolog, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RL5_SHEAM
Sequence: MAKLHDKYKETVIAELSKKFGYTSVMQVPRIEKITLNMGVGEAVADKKIMENAVRDMTAIAGQKPVVTVARKSVAGFKIREGYPIGCKVTLRGERMWEFFERLLDIAIPRIRDFRGLSAKSFDGRGNYAMGVREQIIFPEIDYDKIDRVRGMDIVITTTAKNDEEGRALLDAFNFPFKK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: DER_MYCLE
Sequence: MSQDGTWSDESDWELDDSDLAEFGPVVAVVGRPNVGKSTLVNRILGRREAVVQDVPGVTRDRVSYDAMWTGRRFVVQDTGGWEPDAKGLKRLVAEQASVAMRTADAVILVVDVGVGATDADEAAARILLRSGKLVFLAANKVDGEKGESDASALWSLGLGEPHAISAMHGRGVADLLDKVLAALPNVAESTSLDGGLRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDSLIEMGGRVWRFVDTAGLRRKVGQASGHEFYASVRTHGAIDSAEVVIMLIDASEPLTGQDQRVLSMVIDAGRALVLAFNKWDLVDEDRCDLLEREIDRELVQVRWAQRVNISAKTGRAVQKLVPAMENSLASWDTRIATGPLNIWIKAVVAATPPPVRGGKQPRILFATQATARPPTFVLFTTGFLEACYRRFLERRLRETFGFEGSPIRINVRVREKRGLKRR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: NEUR2_RAT
Sequence: METCPVLQKETLFHTEVYAYRIPALLYLKKQKTLLAFAEKRASRTDEHAELIVLRRGSYNGATNHVKWQPEEVVTQAQLEGHRSMNPCPLYDKQTKTLFLFFIAVPGRVSEQHQLQTRVNVTRLCRVTSTDYGMNWSPVQDLTETTIGSTHQDWATFAVGPGHCLQLRNRAGSLLVPAYAYRKLHPVHKPTPFAFCFISLDHGHTWELGNFVSENSLECQVAEVGTGAHRVVYLNARSFIGARVQAQSPNDGLDFQDNQVVSKLVEPPHGCHGSVVAFHSPTSKPDCLRHVAAYTHPTDSRNRTNLGVYLNQTPLDPTAWSEPTLLATGTCAYSDLQIWGLGPDGSPQFGCLYESGNYDEIIFLMFTLKQAFPTVHGAQ
What is the function of this protein?
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides.  Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate.  Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles.  Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form.  Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages.  Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer.  Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues.
What are the official names of this protein?
Sialidase-2, Cytosolic sialidase, N-acetyl-alpha-neuraminidase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 33 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MURC_MYCUA
Sequence: MTAEQLPPELQRVHMVGIGGAGMAGIARILLDRGGLVSGSDAKESRGVHALRARGALIRIGHDASALDLLPGGVTSVITTHAAIPKTNPELVEARRRGVPVMLRPVVLAKLMDGRITVMVTGTHGKTTTTSMAIVALQHCGRDPSFAVGGELGEAGTNAHHGSGDYFVAEADESDGSLLEYTPHVAVVTNIEADHLDFYGSTEAYVGVFDAFVERLAPGGALVVCADDPGSAALAERSAELGIRVLRYGSAGHAGAALAATLVSWEQRGTGAVAQIQLAGEADPRSMRLSVPGRHMALNVLGALLAAIEVGAPVGEVLDGLAGFEGVRRRFELVGTAESVRVFDDYAHHPTEVRATLEAVRSVVRQSGSGRLLVVFQPHLYSRTKAFAAEFGSALDAADEVFVLDVYAAREQPLTGISGASVAEHVTVPVRYLRDFSAVAEVVAAAAGPGDVVVTMGAGDVTLLGPEIVAALRMRADRSEPGRPGVLQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NARK_ECOLI
Sequence: MSHSSAPERATGAVITDWRPEDPAFWQQRGQRIASRNLWISVPCLLLAFCVWMLFSAVAVNLPKVGFNFTTDQLFMLTALPSVSGALLRVPYSFMVPIFGGRRWTAFSTGILIIPCVWLGFAVQDTSTPYSVFIIISLLCGFAGANFASSMANISFFFPKQKQGGALGLNGGLGNMGVSVMQLVAPLVVSLSIFAVFGSQGVKQPDGTELYLANASWIWVPFLAIFTIAAWFGMNDLATSKASIKEQLPVLKRGHLWIMSLLYLATFGSFIGFSAGFAMLSKTQFPDVQILQYAFFGPFIGALARSAGGALSDRLGGTRVTLVNFILMAIFSGLLFLTLPTDGQGGSFMAFFAVFLALFLTAGLGSGSTFQMISVIFRKLTMDRVKAEGGSDERAMREAATDTAAALGFISAIGAIGGFFIPKAFGSSLALTGSPVGAMKVFLIFYIACVVITWAVYGRHSKK
What is the function of this protein?
Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane (PubMed:2668029, PubMed:11967075, PubMed:15667293, PubMed:16804183, PubMed:23665960, PubMed:25959928).  Functions as a nitrate/nitrite exchanger, and protons are unlikely to be co-transported (PubMed:2668029, PubMed:15667293, PubMed:23665960, PubMed:25959928).
What are the official names of this protein?
Nitrate/nitrite antiporter NarK, Nitrate/nitrite exchanger, Nitrite extrusion protein 1, Nitrite facilitator 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GGGPS_SULAC
Sequence: MKFRGKVARYISEILEEGKTLHFSLFDPDKIFDLDSLHDIASKLIEAGTDVFLIGGTLGISQDKLDNILSILEEFSIPLIIFPSNVNLISNKADAILFLSLLNSDDLYYIVGAQIVAAPIIKRIGLEVLPTAYLIIGHGGTAGHIGRARVIPYDNIELIVSYSLAANYMGMKYIYLEAGSGASETVKPEAIKVVKNTVKDGVVIVGGGVTSEERARNLVLAGADIIVTGNVIERDHQKALKIIKEIKSIRRTSNAIK
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).  This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Geranylgeranylglyceryl phosphate synthase, GGGP synthase, GGGPS, (S)-3-O-geranylgeranylglyceryl phosphate synthase, Phosphoglycerol geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTYBC_PASMU
Sequence: MATIDNAMIHSLIQHLGGKSNIQSVTNCMTRLRVTLHDSSVVDKDELKKIQGVLGVVEADEQLQLILGPGKATKAAEMMKASLGDNMSSPSLQEIARTQKQQIKSAQTSSIHQFFAKFATIFTPLIPGFIGAGLLLGLATVLQQAFVAGVENPNAFLVDLIAYMKVFSKGLFSFLSILIGYNAAKAFGGSGVNGAILASLFILGYNPEATKGIYSGLSNFFGLTIDPRGNIIGVLIAAIVGAKVERWVRKFIPDSLDMALTSTVTLLIMGCFTFLFIMPIGVYLFNGMSWLFSNLNGNPLGTAVLAGLFLISVMLGIHQGFVPVYFALVETQGFNALFPVLAMAGAGQVGAALALYFKANKGAVLRDQIKGAIIPGFLGIGEPLIYGVTLPRVKPFITACIGGAAGGFTIGLIAYLGFPMGLNTVFGPSGLLAIPLMTSPNGVLPAIATYLLGTVVAYATGFITTYFFATKDVDLS
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P.  Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring.
What are the official names of this protein?
PTS system N-acetylmuramic acid-specific EIIBC component, EIIBC-MurNAc.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LYAM3_SHEEP
Sequence: MASCPKAIWSWRFQRVVFRSVQLLCFSILIFELMTQKEVSAWTYHYSDKPYSWNYSRAFCQKYYTDLVAIQNKNEIAYLNETIPYYNSYYWIGIRKIDNKWTWVGTKKTLTEEAENWADNEPNNKKNNQDCVEIYIKSPSAPGKWNDEPCGKRKRALCYRASCQDMSCSKQGECIETIGNYTCSCYPGFYGPECEYVRECGEFDLPQNVHMNCSHPLGNFSFKSQCSFHCAEGYALNGPRELECLASGIWTNSPPQCVAVQCPALKSPEQGSMSCFHSAKAFQHQSSCSFSCEEGFTLVGPEVVHCTALGVWTAPTPVCKAIACESLESPVHGSMDCSPSPRAFQYNTSCSFRCAEGFTLRGADTVRCADSGEWTAPAPVCQALQCQDLPTSNKARVNCSHPFGDFRYQSTCSFTCDEGSFLVGASVLQCLDTGNWDAPFPECQAVTCAPLPNPQNGEKTCVQPLGGSSYKSTCWFTCHEGFSLSGPERLDCTPSGHWTGSPPTCEASKCPELSAPEQGSLDCPDTHGEFIVGSICHFSCNEGLKLEGSNHVECTASGRWTAPPPSCKVDTVSAPAPGLRCPSLIAPNQGTMSCQHHLRNFGLNTTCHFGCKAGFTLMGESALQCRPSRQWTAVAPTCRAVKCSKLPVTEPIVMNCSNPWGNFSYGSTCSFHCPEGQLLNGSERTACQENGQWSTTMPTCQAGPLTIQEALTYIGGAAAGTTGLVTSSILLALLRRRRRQKDDGKSPLNPQSHLGTYGVFTNAAFDPSP
What is the function of this protein?
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes.  Mediates the interaction of activated endothelial cells or platelets with leukocytes.  The ligand recognized is sialyl-Lewis X.  Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
What are the official names of this protein?
P-selectin, CD62 antigen-like family member P, CD62P antigen, Granule membrane protein 140, GMP-140, Leukocyte-endothelial cell adhesion molecule 3, LECAM3, Platelet activation dependent granule-external membrane protein, PADGEM.
What is the protein family that this protein belongs to?
Belongs to the selectin/LECAM family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: H2AB1_MOUSE
Sequence: MARKRQRRRRRKVTRSQRAELQFPVSRVDRFLREGNYSRRLSSSAPVFLAGVLEYLTSNILELAGEVAHTTGRKRIAPEHVCRVVQNNEQLHQLFKQGGTSVFEPPEPDDN
What is the function of this protein?
Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells (PubMed:28366643).  Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:19506029).  Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes (PubMed:19506029).  In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643).  Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643).  Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643).
What are the official names of this protein?
Histone H2A-Bbd type 1, H2A Barr body-deficient, H2A.Bbd, Histone H2A-like 2, H2A.L.2, H2AL2, Histone H2Alike 2, Testis-specific expressed gene 1 protein, TSEG-1.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847).
Protein: REP10_ECOLX
Sequence: MDKSSGELVTLTPNNNNTVQPVALMRLGVFVPTLKSLKNSKKNTLSRTDATEELTRLSLARAEGFDKVEITGPRLDMDNDFKTWVGIIHSFARHNVIGDKVELPFVEFAKLCGIPSSQSSRRLRERISPSLKRIAGTVISFSRTDEKHTREYITHLVQSAYYDTERDIVQLQADPRLFELYQFDRKVLLQLKAINALKRRESAQALYTFIESLPRDPAPISLARLRARLNLKSPVFSQNQTVRRAMEQLREIGYLDYTEIQRGRTKLFCIHYRRPRLKAPNDESKENPLPPSPAEKVSPEMAEKLALLEKLGITLDDLEKLFKSR
What is the function of this protein?
This protein is essential for plasmid replication; it is involved in copy control functions.  In vitro, binds to the DNA repeat units, BCDD'D'', EFG and HIJ (By similarity).
What are the official names of this protein?
RepFIB replication protein A.
What is the protein family that this protein belongs to?
Belongs to the initiator RepB protein family.
Protein: H16B2_CYRHA
Sequence: MNTVRVAFLLVFVLAVSLGQADKDENRMEMQEKTEQGKSYLDFAENLLLQKLEELEAKLLEEDSEESRNSRQKRCIGEGVPCDENDPRCCSGLVCLKPTLHGIWYKSYYCYKKRSA
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
U11-theraphotoxin-Hhn1b, U11-TRTX-Hhn1b, Hainantoxin-XVI-2.2, HNTX-XVI-2.2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 14 (magi-1) family. 01 (HNTX-16) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AUGNB_DANRE
Sequence: MSLHSLCVPTILLISVLSICLSSGGSSDSKLHRILIKRDAKEIESRPKAYISVQQSKAKEFLSGLHRTKRNVWDRSRPDVQQWIQQFMYMGYDEARLETDLSYWMDQARSNDQGRQHHHDENAPMSQQDPRYNRHGANVNYDYY
What is the function of this protein?
Probable hormone (By similarity).  Required for the proper formation of the central nervous system by attenuating cell proliferation during development (By similarity).
What are the official names of this protein?
Augurin-B, Esophageal cancer-related gene 4-B protein homolog.
What is the protein family that this protein belongs to?
Belongs to the augurin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Apical cell membrane.
Protein: COFI_CRYNB
Sequence: MSSGVQPTQECLEKFQELKTGKKLTYVIYGLSEDKRSIVVLKASEDKDFDSFVAELPEKDCRWAVYDFEFTLPGGEGVRNKLCFIVWSPDDASVKNKMIFASSKEAIRRRLDGIHTEIQATDFSEITKDALFEKATRK
What is the function of this protein?
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner.  It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin.  Binding to F-actin is regulated by tropomyosin.  It is the major component of intranuclear and cytoplasmic actin rods.  Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends.  In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments.  Involved in the maintenance of the contractile ring once formed.  In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity).
What are the official names of this protein?
Cofilin, Actin-depolymerizing factor 1.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Note=Throughout the cytoplasm (but not on the cytoplasmic cables) and major component of the cortical actin cytoskeleton.