PharMolix/UniProtQA huggingface dataset:
Protein: SYA_WIGBR
Sequence: MKKTTEIRNIFLNFFYEKKHKIMDSSTLIPDNDKTLLFTNSGMNQFKDIFLGFKKPKYIRVATAQRCIRVGGKHNDLNMIGKTNRHHTFFEMLGNFSFGSYFKSDTIQFAWELLTSKKWFDLSKEKLIVTIYYKDIESYNLWVEKTNINPKNIIFIKDKNNILYNSDNFWTMGDTGPCGPCSEIFYFFGKSINYKNIKIYDEEYIEIWNLVFMQFNLHLNGKLSRLPITSIDTGMGLERISCVLQKVNSNYSIDLFKKLIYEISKIIEIKNIKNYSLRIIADHIRSAIFLIYDGVIPSKEGRGYVLRRIIRRAIFHGNYILNKSCFFYKLVSPAINIMSYIDSKIIKKKKEIENIIKEEEKIFFFSIKKGMIFLNKNLKKIKNNILKGEIAFKLHDTFGFPIDLTNDICIKNKINVDEKGFFHAMNEQKNKSYKNSCFNKFNLKLLNNYCTKFCGYSYLKCESQILNIYNLKEEIKEIKENQEGIIILDKTPFYGESGGQVGDSGEIKSKDGVFSVIDTKKLGNYFYHYGKVIQGILKINNKITAYVNKIKRNKISLNHSSTHLLHYAINCLLDKNIIQKGSLICEKYLSFDFSYGKKINIEKINEIENIINEKIRDNVIIHSNNMDLKNALKIGAKALFKNKYKDLVRVLNIGDFSIELCGGTHANRTGDIGCFVITNFSKISSDTYRIKAITGETAIAFIQKKFNDINTISSLIKSNSNEIVNKIEKITENLKILEKKNKNLKNKIIKNYIKLIFNKIKKINNFEIIMDYFNEEIDKIILREILNKVKTNLKNGIVILASIKKDNLYIVTGVTNNLVNIITAKEIISYFKEIKSIKGGGNSYFAEAVGVVNLIDLKSMFKKIFMILSKNLK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBM3_CAPHI
Sequence: MSSEEGKLFVGGLNFNTDERALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHASNAMRAMNGESLDGRQIRVDHAGKSARGSRGGAFGSYERGRGYPRGGGDQGYGSGRYDNRPGAYGFGYGYGYGRSRDYGGRSQGGYDRYSGGNYRDNYDN
What is the function of this protein?
Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures.  Reduces the relative abundance of microRNAs, when overexpressed.  Enhances phosphorylation of translation initiation factors and active polysome formation.
What are the official names of this protein?
RNA-binding protein 3, RNA-binding motif protein 3.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, dendrite. Note=Localizes in mRNA granules in dentrites.
Protein: ISPF_CHLPB
Sequence: MRIGTGIDVHQFAEGRKLIVGGVEIPHSKGLKGHSDADVLLHAISDALLGAAALGDIGKHFPDTSPQFKDIDSMILLQHVGKLIAEEGYAIGNIDSVLVMEKPKVAPHIMAMRGNIAACLDIDVSKVAVKATTTEKLGYVGREEGVAAHAICLIEERKQ
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: ZIP10_ARATH
Sequence: MTKSHVIFSASIALFLLLSISHFPGALSQSNKDCQSKSNYSCIDKNKALDLKLLSIFSILITSLIGVCLPFFARSIPAFQPEKSHFLIVKSFASGIILSTGFMHVLPDSFEMLSSPCLNDNPWHKFPFAGFVAMMSAVFTLMVDSITTSVFTKSGRKDLRADVASVETPDQEIGHVQVHGHVHSHTLPHNLHGENDKELGSYLQLLRYRILAIVLELGIVVQSIVIGLSVGDTNNTCTIKGLVAALCFHQMFEGMGLGGCILQAEYGWVKKAVMAFFFAVTTPFGVVLGMALSKTYKENSPESLITVGLLNASSAGLLIYMALVDLLAADFMGQKMQRSIKLQLKSYAAVLLGAGGMSVMAKWA
What is the function of this protein?
Probably mediates zinc uptake from the rhizosphere.
What are the official names of this protein?
Probable zinc transporter 10, ZRT/IRT-like protein 10.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VHC1_YEAST
Sequence: MVSRFYQIPGTHRPSSAISSSNESSSLLSARRISQTYFNYQATPECQKVSSKYDPDNPNKDKLGTYDGVFVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLSYTINLLTTLSISAISTNGTVRGGGAYYMISRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPLLYNLGYSAQGEPPAALGELLPRGHWHEFTYATVILFLCFSVAFVGSQTVSRAGNILFLVLAASIFSIPLSALIRSPFTEGGISYTGPSWQTFHDNLLPHLTKGAAGSLLKGKETFNDLFGVFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLFTFICYAVVVFSMGCSIPRRSLYDEVQIIQTISSVQWVIFMGEMATSLFSIIVGMLGAAYVLEAIAKDNIIPGLEIFAHSPLYSLIFTWILTQLCLFSDVNKIATFITMTFLMTFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALLSVVAMLIVDGISASVLFLAMILLFLFIHYFSPPKSWGDVSQSLIYHQVRKYLLRLRQDNIKYWRPQILLFVDNPRTSWNLIRFCNHLKKGGLYILGHVAVTADFPKQLNELKTQQKAWMKIRDMAAIKAFVQVGTGPSLIWGIRNVFIGSGLGGMKPNITVVGFFDLESYRKHIPQSRSQNNLQKQVEIKATVPRSTCSDVKINVPLPTDECKNETKVNVQQWVQIVEDLSLMQSNIAIAHGFKNLEIPNKRDSCFPKKTIDLYPIQMCGKVEAKGDQPAAITTNFDTYTLILQLAAILVTVPEWKRTHSLRVILFVEQEYHRTNETQRMKKLLQVLRIDAEVLVVSLDQFRVYNTIVKGDPIVFDYVNSKLADNEWWKDLVEARDTLKPKRRFSTIEPQTIAKQFTQSRKYTSGVQKLGVSFTMNTRMPTNRIDTPCESEDSDLDTDLTSIRDAFSASTNISVGKDLTTKSKTGSDRTNLLVKNLQSDVSTQSLRPVFSSNTLPRTRVVEDGTGEQPTLIPIAEPDLSNGNGTGSGIGNGNKLKKPVLPELSPCCSKDSLVTAMQNLGFNDLPSTAQHLVLNDVMTQMSKSSDLIFSTLPVPALGTHEDHDASLQYVEDLDIWLEGLPPCMLINSQTMTVTTAL
What is the function of this protein?
Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane.  Involved in vacuolar osmoregulation.
What are the official names of this protein?
Vacuolar cation-chloride cotransporter 1, Vacuolar homolog of CCC family protein 1.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: PAN3_DEBHA
Sequence: MNINLDSAKDTFCKNVLIYGYCKYENKGCAFSHTVKPTSSVPGSQGSNATTNSSGNTNADMKKKFNFNTPSFQPSTVPNLTNKFSNLSPNLKEIPVFVPSGGMSNADSGGMNEPEMNDSVTPNKKFNASTPSFMPSNPYISNNDQISAPSPVMAQSVSTPGAKANGNIQHNPYLPGNAGTPQPTSAVAAPNSADVFFQQPTSSYPLQHHLYAPAPPPRLTIPLPPHEINVNSMFIPNDLRETLLKRNEATLQTLPRSNLPDHVNIYHSLVPIDTSFENISKVYELPSFVYKVFSNVDGNPYALRKIDIQSVLRITNELPFKYIKKWKSVKCANIVQLQEAFTSMAFGGSYSSLIVTYDYFPNSNTLQEQHISRRLGGKLEPITEELLWNYVIEITNALINIHENNLAARSALHLSKILVTNKNRVRLGGVGISDILNYEDDEEQIQQKGLDAFRHELQQADIKKFGKLILDLAALCLPNNARNHEPKDLISLLKTSTTVNFSGEFINLLTELNMNTSDLQEFNRNHLSRRILNFCSNAQDSQDFMESQLSTELENARVFRLITKLNFIIDRPEYDNDPNWQENGNKYIIKLFRDYIFFQYDEFGKPVCDLSRVLTNLNKLDAGIDEKFLLVNKDEKNCIIVSYKEIRDIIDSAFRTLTRG
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.  PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit PAN3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_SHESH
Sequence: MSTRRETRAQAQQFIDNLKPLQHPNSEKVYLVGSRDDIRVGMRQIHQSETMIGGTESHPVLESNPPLKVYDCAGPYSDPNAKINVREGLDKFRANWILERNDTEQLIAASSGFTQQRLADYGLDHLRFDSLLSPRKAKQGQCVTQLHYARQGIVTPEMEYIAIRENMALSEVTDEALTQKAEGESFGAAISQPITPEFVRQEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVNGVAEDLTWEIFRDTLLEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHLENFLYEHFRDICELCAAYDVSLSLGDGMRPGSIADANDEAQFSELETLGELVKIAWEYDVQTIIEGPGHIPMNLIKENMDKQLEVCDEAPFYTLGPQTTDIAPGYDHFTSGIGAAMIAWYGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAGDVAKGHPTAQIRDNALSKARFEFRWEDQYNLGLDPDTARAYHDESLPQESAKVAHFCSMCGPKFCSMKISQEVREYAAAQEVKLHTDTEFKAKSVKESGMAQMSAEFKAKGAALYHESGALVEDVELVETEG
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: FOLR1_BOVIN
Sequence: MAWQMTQLLLLALVAAAWGAQAPRTPRARTDLLNVCMDAKHHKAEPGPEDSLHEQCSPWRKNACCSVNTSIEAHKDISYLYRFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIREVNQRWRKERVLGVPLCKEDCQSWWEDCRTSYTCKSNWHKGWNWTSGYNQCPVKAACHRFDFYFPTPAALCNEIWSHSYKVSNYSRGSGRCIQMWFDPFQGNPNEEVARFYAENPTSGSTPQGI
What is the function of this protein?
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells.  Has high affinity for folate and folic acid analogs at neutral pH.  Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity).  Required for normal embryonic development and normal cell proliferation (By similarity).
What are the official names of this protein?
Folate receptor alpha, FR-alpha, Folate receptor 1, Folate-binding protein 1, FBP, Milk folate-binding protein.
What is the protein family that this protein belongs to?
Belongs to the folate receptor family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-like-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Protein: DDL_JANSC
Sequence: MAGLSSLPSRVVVLMGGPSAEREVSLSTGRGCAEALRGEGFDVIEVDPGVTHAGAELCARLQEIQPDVVFNALHGRWGEDGCVQGLLEWMRLPYTHSGVLSSALAMDKTRAKTALKAHGLPVVDSIIAPKEAVVAAHVMATPYVVKPNNEGSSVGVYLVNEAANGPPHLSDDMPDEVMVETYAPGRELTVSVLGDAPGDPGALTVTDILTDGWYDYDAKYKPGGSRHVVPAQIPQEIWDACMDMAVRAHTILGCKGVSRTDYRWDEARGLDGLIILEVNTQPGMTPTSLTPEQGEAVGMSFGKLCRWLVEDATCDR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_HALOH
Sequence: MGKLFGTDGVRGVANKELTGELAYKLGRAGGYYLTRDYKGGKKPVVLIGKDTRISGDMLEAGLVAGLTSAGIDVIKLGIIPTPGVSFLTSSLDVQGGVMISASHNPIADNGIKFFNQKGYKLTDEMEDEIENLIFNKLETIPYPTHEKIGVVDSAPEYYHKYVDYLKETVDSDFSGLKIVVDCANGAAYKVAPEVLKKLRADVMVINGSSDGHKINVNCGSTNPEILRQKVIDEKADLGIAHDGDADRVIMVDERGQVVDGDKIMAICALDMMERGVLNKNTLVTTPYSNLALKEIMEEKGGQVVITKNGDRYVLKEMLENGYNLGGEKSGHIIFLDYNNTGDGVLTALQVVNIVKRTGHKLSELAAVLKPWPQRLANIKVKYKQKLKTSELIKQEISKAEQLLGTEGRVFVRASGTEPVIRLMLEGKDEKRLLELEKKLGSIIEEELN
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RL19_CHLTR
Sequence: MGNLIKELQDEQCRTDLADFCVGDTIRVATNISEGGKERVQVFQGTVMARKGGGAGETVSLHRVAYGEGMEKSFLLNSPKIVSIEVVKRGKVSRARLFYLRGKTGKAAKVKELIGSRAAKK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ARGE_VIBC1
Sequence: MQLPSFLEVYEGLISTSSISSTDPSWDQGNAKVIEKLASWFKDLGFSVEVIEVEPGKHNMIARMGEGEGGLLLAGHSDTVPFDEGRWSFDPHKLTEKDNRFYGLGTADMKGFFAFIYEAVKKIDWSKQTKPLYVLATCDEETTMLGARHFTENAPFKPDYCIIGEPTSLVPIRGHKGHVANAIRVTGKSGHSSDPALGVNAIEIMHEVMFAMMQLRDKLVKEYHHPGFAIPSPTLNLGHIHGGDSANRICGCCELHYDVRPLPGISLDGLENMLRGALKEVEAKWPGRLEIIPLHDPIPGYECQHDHPFIGGVEEICQTSSETVNYCTEAPFLQQLCPTLVLGPGSIDQAHQPDEFLSFDFIDPTIDVLSRAMVKYCC
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCNC_XENTR
Sequence: MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLISAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILNKMPKPKPPPNSEGEQGTNGSQSSGYSQS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
What are the official names of this protein?
Cyclin-C.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEPA_AYWBP
Sequence: MNIEQLKERQKCIRNFSIIAHIDHGKSTLADRILEFTGTIDKRIMKEQILDSMDLERERGITIKLNAVEINYQSKDGKNYIMHLIDTPGHVDFSYEVSRSLAACEGALLIIDASQGIQAQTLANVYLAVENNLTLIPVLNKVDLPSADVPKVKEEIKETLGLDPEKALIASGKTGLGVIDILEQIVTRISPPQGDIQKPLQALIFDSYFDSYKGVVPSIRIVNGTVKKGDQIRFMASNSVYEVVEVGVYNPKQIVKDFLAPGDVGYITAAIKSINHVRVGDTITSQTNQALLPLLGYKQMNSVVFCGLYPVETNKYDILKEALEKLKLNDSSLIFEPESSNALGLGFRTGFLGLLHMEIIQERISREFGVEVIATAPSVIYHVYSTKGEKFLVDNPSKLPSTQMIDRIEEPFIKATIMCPEIYIGKVMKLSQNKRGALQNIEYIDSQRVMINYLLPFSEIIYSYFDKLKSLTKGYASFDYEIDKYRVSKLQKMDILLNGEIVDALSLIVHHDFAYERGKAICETLKEFIPKQMFEIPIQAALGKKIIARQTIKAMRKDVTAKLYGGDVTRKKKLLEKQKKGKKKMKTLGKVQLPQKAFLAILATK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PPE41_MYCTU
Sequence: MHFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIAHSTVLVAPVSPSTASSRTDT
What is the function of this protein?
The PE25/PPE41 dimer induces both a strong humoral and cellular immune response (PubMed:18974870).  The dimer induces necrosis, but not apoptosis, in mouse macrophage cells (PubMed:25379378).  It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses (PubMed:26318856).
What are the official names of this protein?
PPE family protein PPE41.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
What are the subcellular locations of this protein?
Secreted. Cell surface. Note=Secreted via the ESX-5 / type VII secretion system (T7SS).
Protein: GLRX3_ECO57
Sequence: MANVEIYTKETCPYCHRAKALLSSKGVSFQELPIDGNAAKREEMIKRSGRTTVPQIFIDAQHIGGCDDLYALDARGGLDPLLK
What is the function of this protein?
The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase.  In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase (By similarity).
What are the official names of this protein?
Glutaredoxin 3, Grx3.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
Protein: MDTJ_ECOK1
Sequence: MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGAV
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtJ.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYSZ_ECOLU
Sequence: MVSSFTSAPRSGFYYFAQGWKLVSQPGIRRFVILPLLVNILLMGGAFWWLFTQLDVWIPTLMSYVPDWLQWLSYLLWPLAVISVLLVFGYFFSTIANWIAAPFNGLLAEQLEARLTGATPPDTGIFGIMKDVPRIMKREWQKFAWYLPRAIVLLILYFIPGIGQTVAPVLWFLFSAWMLAIQYCDYPFDNHKVPFKEMRTALRTRKITNMQFGALTSLFTMIPLLNLFIMPVAVCGATAMWVDCYRDKHAMWR
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YD018_YEAST
Sequence: MKHSQKYRRYGIYEKTGNPFIKGLQRLLIACLFISGSLSIVVFQICLQVLLPWSKIRFQNGINQSKKAFIVLLCMILNMVAPSSLNVTFETSRPLKNSSNAKPCFRFKDRAIIIANHQMYADWIYLWWLSFVSNLGGNVYIILKKALQYIPLLGFGMRNFKFIFLSRNWQKDEKALTNSLVSMDLNARCKGPLTNYKSCYSKTNESIAAYNLIMFPEGTNLSLKTREKSEAFCQRAHLDHVQLRHLLLPHSKGLKFAVEKLAPSLDAIYDVTIGYSPALRTEYVGTKFTLKKIFLMGVYPEKVDFYIREFRVNEIPLQDDEVFFNWLLGVWKEKDQLLEDYYNTGQFKSNAKNDNQSIVVTTQTTGFQHETLTPRILSYYGFFAFLILVFVMKKNH
What are the official names of this protein?
Uncharacterized acyltransferase YDR018C.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y1544_SYNS3
Sequence: MNHLRLQILDQATCERLLERLANEAEWLDGSLTAGAHAKGGKRNFQINYDSALRKEIHELVERAMWNHPVVKGFCLPRKLHRFLISKTEKEGGYDTHVDNAYMSSGRSDLSFTLSLTDDTMYEGGDLEIDSISESYPIKLKQGEILIYPSTSLHRVCNVTSGIRTVCVGWIESYVQAENDRICLFQLESGARAVLAKHGRSDELDLIFLAYTNLLRRLGG
What are the official names of this protein?
PKHD-type hydroxylase sync_1544.
Protein: GUAA_PROMM
Sequence: MSNSQSEGKRQPAIVILDFGSQYSELIARRVRETEVYSLVMSYCTSADELRQLAPKGIILSGGPSSVYAERAPLCDPNIWDLGIPVLGVCYGMQLMVQQLGGRVEAAIGKAEYGKAPLQVEDPRDLLTNVESGSTMWMSHGDVVRDLPEGFVRLAHTANTPDAAVADHNRQFYGVQFHPEVVHSSHGIALIRNFVYHICGCEPNWTTTAFIEEAIAQVQAQVGQKRVLLALSGGVDSSTLAFLLKKAIGDQLTCMFIDQGFMRKGEPEFLMDFFDQKFHINVEYINARQRFISKLKGIIDPEEKRKIIGTEFIRVFEEESNRLGPFDYLAQGTLYPDVIESSGTNIDPKTGERVAVKIKSHHNVGGLPKDLQFKLVEPLRRLFKDEVRKVGRALGLPEEIVRRHPFPGPGLAIRILDEVNDEKLNCLRDADLIVREEIREAGLYHEIWQAFAVLLPVRSVGVMGDKRTYAWPIVLRCVSSEDGMTADWSRLPHELLERISNRIVNEVRGVNRVVLDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: ARCD2_LACLM
Sequence: MENKKTKGISLFALLAIIISGAIGGGVFNLANDLARGSTPGGVVISWLFIGFGILMLVLSFNRLITIKPDLSGVSDYARAGFGDFVGFLSGWGYWISAWTGTIGFAVLMMTSADYFFPSKFANSNGSLTILSVIIVSIISWILMLLVDRGVETAAAVNAIVMIAKLIPLVVFSITGIILFKANVFTQHFWQTFTTNFAADGSVKDFVWHAMTVSGLLSQIKGSLMVMVWVFVGIEGATMMGNRAKKKSDTAKATVIGLAVLLVIYVLLSLLPYGYMDQASLANVKAPGLVYILNEMVGGWGGSLMAVGLMISLLGAWLSWTMLPVEATQQLAEQKLLPSWFGKLNKYHAPSNSLLITQLMIQIFIIITYFVANAYNVFIYMATAVIMICYALVGAYLFKIGLKEASVKNILIGFFTFAFQALALYLSGWQYVWLAMILYTIGFLLFIGAKKESHQSISVKEWLGMLVVTVLGVLAIVVLICGAKAGTAFDLRGLLGF
What is the function of this protein?
Catalyzes electroneutral exchange between L-arginine and L-ornithine (PubMed:23144255).  Can also efficiently translocate L-alanine (PubMed:26324452).  May function in vivo as a L-arginine/L-alanine exchanger in a pathway together with the arcT gene, which is found adjacent to the arcD2 gene in the ADI gene cluster (PubMed:26324452).
What are the official names of this protein?
Arginine/ornithine antiporter ArcD2, Arginine/ornithine exchanger.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CSD_XYLFT
Sequence: MDRINTSAAPPTSPDWERLRADFPLLQRHVHGKPLIYFDNANTAQKPQAVITATDTFYRRHNANISRAVHTLGTEATEAYEATRAALATLLNVPMHELVLCSGTTFAINLIAYSWALPRLRTGDVILVSRMEHHANIVPWQLIAERTGARIQVADILPNGTLDLDALHTLMTPQVKLLAITHVSNVLGTVNPIHDICRQARQRGITTVVDGSQAAPHRHINIPAIGCDFYAITGHKLYGPTGTGALWARREHLHIMPPFLGGGEMIKEVSFDGTLFNTPPHKFEAGTPNIAGFIGLSAAVDYVRRIGIDQIETRETELLAHLTEELQKIDGMRLFGTAPNKAAVVSFMIEGTHAHDLATLLDLEGVAVRSGQHCAHPLLQYYGVTATCRASLAFYNTHEEIERFITALLKVRKLLG
What is the function of this protein?
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
What are the official names of this protein?
Probable cysteine desulfurase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
Protein: RL6_BRASO
Sequence: MSRIGKKPVTVPSGVTATVDGQTVKMKGPKGQLQFLVHDDVEVKFENGQVKVAPRAETKRARSLYGTARAQIANLVEGVTKGFEKKLEITGVGYRAAMQGKNLQLALGYSHDVVYQIPEGITIAVPKPTEITITGIDPQRVGQVAAEIRAYRPPEPYKGKGVKYAGEFIFRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: LEUD_KINRD
Sequence: MEKFSVHRGVGVPMRRTDVDTDQIIPAVYLKRVTKTGFEDALFAGWRKDPGFVLNQEPYRPGSVLVAGQDFGTGSSREHAVWALRDYGFRAVLAPRFGDIFRGNAGKQGLLAAVVAQSDIDLIWKALEAHPGTEVTVDLIERIVQVDDFTAPFEVDDYVRWRLVEGLDDIGLTLRHADAITDFEARRPSFKPTTTPLAPSA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.