PharMolix/UniProtQA huggingface dataset:
Protein: SYI_BORPD
Sequence: MDYKKTLNLPDTPFPMRGDLAKREPAWVAQWEENHVYQAIRAASRGRPRFVLHDGPPYANGDIHIGHAVNKVLKDIIVKSRNMAGYDAHYVPGWDCHGMPIEIQIEKKFGKHLPVTEVQAKARAYALEQIDRQRKDFKRLGVLGEWDRPYLTMNFSNEANEIRALGGILQKGYVFRGLKPVNWCFDCGSALAEAEVEYADRVDPAVDVAFPFADKPGLAAAFGLDSVDDGAVVIWTTTPWTIPANQALNMHPELEYALVRATPAPAHGPLLLLARERVEACLKAWGLQGEVIATAPGAALSGLRFHHPLASADAGYARTSPVYLGDYVTLDAGTGVVHSAPAYGIEDFVSCKAHGLSDDDILNPVLGDGKYADSLPLFGGLSIWDANPRIIEALKAAGSLMDVQKLSHSYMHCWRHKTPIIYRATSQWFAGMDVKPADGGPTLRESALAGIDATAFYPSWGRARLHAMIANRPDWTLSRQRQWGVPMAFFVHKETGALHPRTAELLEQVAQRVEQHGIEAWQSLDPRELLGDEADQYEKNRDTLDVWFDSGTTHATVLGGKDQALGGSHGAELAWPADLYLEGSDQHRGWFHSSLLTGCMLYGQPPYKALLTHGFVVDGQGRKMSKSVGNVIAPQKVSDSLGAEILRLWVASTDYSGELSISDEILKRVVEGYRRIRNTLRFLLANVADFDAVSQAVPYGELFEIDRYALTMTAQMQAEVLAHYERYDFHPAVSRLQTFCSEDLGAFYLDILKDRLYTTAAGSLARRSAQTALLDITQALLKLMAPILSFTAEEAWQVLAQSALQHQADVSRTTIFTEVYHALPPFADADALAAKWARLRAIRAEVQRKLEDVRTAGGIGSSLQAEVDLYAGGDDRALLASLGDDLRFVLIVSRATVHEAQGELRVEITPSAHKKCERCWHWRLDVGSDADHPEICGRCVTNLFGAGEPRDKA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_EHV4
Sequence: MAACVPPGEAPRSASGTPTRRQVTIVRIYLDGVYGIGKSTTGRVMASAASGGSPTLYFPEPMAYWRTLFETDVISGIYDTQNRKQQGNLAVDDAALITAHYQSRFTTPYLILHDHTCTLFGGNSLQRGTQPDLTLVFDRHPVASTVCFPAARYLLGDMSMCALMAMVATLPREPQGGNIVVTTLNVEEHIRRLRTRARIGEQIDITLIATLRNVYFMLVNTCHFLRSGRVWRDGWGELPTSCGAYKHRATQMDAFQERVSPELGDTLFALFKTQELLDDRGVILEVHAWALDALMLKLRNLNVFSADLSGTPRQCAAVVESLLPLMSSTLSDFDSASALERAARTFNAEMGV
What is the function of this protein?
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis.  The dTMP serves as a substrate for DNA polymerase during viral DNA replication.  Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae thymidine kinase family.
Protein: THIE_OCEIH
Sequence: MKFDKHMLRKYFIMGSQNCHRDPREILKEAASAGITAFQYREKGKNSLTGTAKVELAKDLKAICHDFQIPFIINDDVDLAKQLDADGIHIGQDDQPVEVVRKQFPNKIIGLSISTNNELNQSPLDLVDYIGVGPIFDTNTKEDAKTAVGLEWIQSLKKQHPSLPLVAIGGINTTNAQEIIQAGADGVSFISAITETDHILQAVQRL
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: COSA_EUTHA
Sequence: MNVEEEIQKLEEEIHRLGSLQSDGSYKVTFGVLFNDDRCANIFEALVGTLRAAKKRKIVAFPGELLLQGVHDKVEITLRPPPPPPQAVAATS
What are the official names of this protein?
Costars family protein ST45-2.
What is the protein family that this protein belongs to?
Belongs to the costars family.
Protein: CLP1_ASPFC
Sequence: MSLPGLELSQTSSEREFVPAPPTQITLSKGSEWRFEVAFGTAIRVKLLAGTAELFGTELAASQTYTFSGTKAAIYTWHGCTLEVSAGDTISTIDGLGSGGLNGEGARGYGAGGCQSEYTAEETPMVEYANVHFALEAMRQEAKATGKDGPRVLILGPENAGKTSVAKILTAYATKVGRQPIVVNLDPAEGMLSVPGTLTATAFRTMMNVEEGWGSSPMSGPSAVPVKLPLVYFYPLQNPLEAEGAVYRPIVSRLALSVTGRMAEDEDTRETGIIVDTPGILSAGKPGSLEIINHIVTEFASSERLYSTMMKNYDNKPTSSASAAASDERITVVKLSKSGGCVDRDAAFMKSVRESQIRTYFFGNPIPSTASAALSMSASSTTNITLSPHAQQLDFDSLAVYNYTIASSDEDEDEYDPSQFGASDTFLPGGRNDAEGPETKHAEETSFTSSVPGLGGPSGDDAASGSSAVPLKKVLPPAPNTLANSLLAVTHTAPNASPAEIRDASIMGFLYVADVDSEKGKIRVLAPIGGRVPPRAIVWGKKWPGEVVGLVG
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
mRNA cleavage and polyadenylation factor clp1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MRH4_ASHGO
Sequence: MSSVGIASASLWLRGPVKSALKGRWLSCEQMRRYGTKSAPAVRKGGHSKKARQAPSLPFVFGRHKQLTGPEFTRRTRIGNLSDKITKFEQLKLLPEVREVMMKVIASESVLNKSLDDEDCGLDDKRVAAFLGQVQPTPIQTAVIKKMAKTLMEPQLQVHMVAAETGSGKTMSYLMPLVDYLKQEEQAAGTEEGRARLGALRSLILVPTHELVEQVYMTLEKLQEPLQLKTFKLDRDTPYKDIVEAFKGRVDIMVTTPGKLRGLFKIRMLHRPDRILSQVRFAVVDEADTLMDQSWVQETYSCIKSLRDANHLVFCSASVPMEFEKAMNKLFPNLQVVASEKLHRINKHSNIKIINVALRPYNGSKMKALAQALYAIMKDGTSEGYEKRCVVFVNEADSVNSIVDTLRDKFGHDVHGLTGEHSLDDRLATIAPFMRSPPRIQDQVRPSELKKPQERRLPNSNIKVADSKDNGQRSVSSPLKVLVTTDVLSRGINFKGVKHVILYDVPAKSIDLVHRVGRTSRMNERGHVYIFVGKKGSAQAKGLNPVVKKNRPIQ
What is the function of this protein?
ATP-binding RNA helicase involved in mitochondrial RNA metabolism.  Required for maintenance of mitochondrial DNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase MRH4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. MRH4 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL332_LACJO
Sequence: MAEHIILECTECGDRSYLSEKNKRKHPERLALKKYCPVERKVTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: MURB_CHLPN
Sequence: MKEAAPMHFPFPVRRSVWLNRYSTFRIGGPANYFKAIHTIEEAREVIRFLHSINYPFLIIGKGSNCLFDDRGFDGFVLYNAIYGKQFLEDARIKAYSGLSFAALGKATAYNGYSGLEFAAGIPGSVGGAIFMNAGTNESDISSVVRNVETINSEGELCSYSVEELELSYRSSRFHRQQEFILSATLQLSKKQVSADHSKSILQHRLMTQPYTQPSAGCIFRNPEGTSAGKLIDAAGLKGLAIGGAQISPLHANFIINTGKATSDEVKQLIAIIQSTLKTQGIDLEHEIRIIPYQPKIHSPVSEK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TP4A1_PONAB
Sequence: MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTALVEKEGIHVLDWPFDDGAPPSNQIVDGWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ
What is the function of this protein?
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis.  May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
What are the official names of this protein?
Protein tyrosine phosphatase type IVA 1, Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=And mitotic spindle.
Protein: PR38A_MACFA
Sequence: MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELRFVGGVYGGNIKPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQKRYVLEEAEQLEPRVSALEEDMDDVESSEEEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPTLRYRRSRSRSPRRRSRSPKRRSPSPRRERHRSKSPRRHRSRSRDRRHRSRSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGNE
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the spliceosome.
What are the official names of this protein?
Pre-mRNA-splicing factor 38A.
What is the protein family that this protein belongs to?
Belongs to the PRP38 family.
Protein: Y3367_CHESB
Sequence: MVDEITNETAQTVAAGQLRAFIERIERLEEEKQTISDDIKDVYAEMKGNGFDVKAVRAIVRLRKKDQAERQEEEAILDLYKAALGMV
What are the official names of this protein?
UPF0335 protein Meso_3367.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: Y1401_SACS2
Sequence: MVFKINLPPEGLFARSLVISELLGLNNVGISIDNDVVNIERKEEFKDNLKNELSQFKLVFNKLKTYKKNYANEVNLAEKVFNGDVEEFFKEDKEEYFLPLIFPEIMEAEKWFGGWSGSGKGSKRTIGVNRQSFILSLLSLGKYQLVSYRAAKEQVTVLALVDTTVMSDMCKPSKKKELRVQSNLIAQLSHISRLLIFSTILDEQGCQEVLLLKEGTHRAEIYERNSHTSLRPLIRFWTLVDDDSVERRITSLANQSPDSLNKVSNYIFEGIRGTLSPVEVAYMIARETYLKEEQSPLTSWDVKKIREALERMRVEMEEVYSST
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
What are the official names of this protein?
Putative CRISPR-associated protein SSO1401.
Protein: FLGB_BUCAI
Sequence: MFNKINQIFNFHQQALNLCSQRQEILSANIANADTPGYKSIDFNFKNELNKTLYKNKKTIFLKKTSPNHLNEKHKNLFLLKTIPVLTNQIKQDGNTVNMDRERIEFLNNSIKYQSSLVFIKNEIKNMMYVLKG
What is the function of this protein?
Structural component of flagellum, the bacterial motility apparatus.  Part of the rod structure of flagellar basal body (By similarity).
What are the official names of this protein?
Flagellar basal body rod protein FlgB.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: RLME_SALAR
Sequence: MTGKKRSASSSRWLQEHFSDKYVQQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYVVTQIGGRGRIIACDLLPMDPIVGVDFLQGDFRDELVMKALLERVGDSKVQVVMSDMAPNMSGTPAVDIPRAMYLVELALEMCRDVLAPGGSFVVKVFQGEGFDEYLREIRSLFTKVKVRKPDSSRARSREVYIVATGRK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_HISS2
Sequence: MKIQLIAVGTKMPDWVTKGFEEYQRRFPKDMPFELIEIPAGKRGKNADIKRILEQEGKAMLSACQKSRIITLDIPGKPWTTEQLAQQLEAWKHDGRNVALLIGGPEGLSPECKAATEQSWSLSPLTLPHPLVRIVVAESLYRAWSLSTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSH_ALKEH
Sequence: MANRPQALKIHPQPVLAPGELDSVRRQLAAASAQERVRWGLARFPGRIVLASSFGAQAAVSLHLVTREQPDIPVVLVDTGYLFPETYRFVDELTERLGLNLQVARPAHSAAWQEARFGRLWEQGVEGIERYNRMNKVEPMQQALETLGADAWFAGLRRQQAHSRQQRQVVEIQNDRVKVHPIIDWTDRDVHRYLTRHDLPYHPLWHEGYVSIGDVHTTRRLADGMSEEETRFFGLRRECGLHDLV
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBS_CHLP8
Sequence: MLSGLVTALRTLTVLPVPGRDAERFSSSLYWFPVVGLVIGGIVVLFARAGMGAGWPELAAVLALLGGFILTRGLHADGLADLADGFFGGRNREAALRIMKDPNVGSFGSLALIGVMLFKWICLLELARAGAYGMIAAGVVLSRTAQVLLAARMPYARSEGGTATAFVEDAGWPHLLVASVSGVVLLFVLLDWQVVPSSILLFGSVVALFFVGWLSHRKIGGITGDVLGACSELVEIAVWFVAALWLKGLFSAIA
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PRTZ1_SCYCA
Sequence: MGSCKPKKKQAPCFLRRRHLRRLNVCKRDTSKTYRRRRHVRRLPKKRRRRC
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine-Z1, Scylliorhinine-Z1.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TMEDA_CANAL
Sequence: MQSLITYIALVFSLFVSSAIGLHLEVPALPNPQPVCIRDFVQENQMVVVNIKTDGSKGDGQRLDLKVTDSLGNEYRNKKDVVGHANVAFTSQHNAAIDICLTNYLDNKWSKHQQTVRSVELDIESGAAARDWNALQASEKLKPVEVELKRIESITEEIVEELRYLKAREERMRDTNESTNSRVKWFSIVVIASLVGFGVWQIQYLRHYFKVKHII
What is the function of this protein?
Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles.  Required for efficient transport of a subset of secretory proteins to the Golgi.  Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
What are the official names of this protein?
Endoplasmic reticulum vesicle protein 25.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Recycles between endoplasmic reticulum and Golgi.
Protein: VP7_ROTPK
Sequence: MYGIEYTTVLFYLISFILVSYILKTITKIMDYLIYRITFIIVVLSMLSNAQNYGINLPITGSMDIAYANSTQNDNFLSSTLCLYYPTEASTQISDNEWKDTLSQLFLTKGWPTGSVYFNEYSNVLEFSIDPKLYCDYNIVLIRFTSGEELDISELADLILNEWLCNPMDITLYYYQQTGEANKWISMGSSCTVKVCPLNTQTLGIGCQTTNATTFETVADREKLAIVDVVDGVNHKLDVTSTTCTIRNCNKLGPRENVAIIQVGGSNILDITADPTTSPQTERMMRVNWKKWWQVFYTVVDYINQIVQVMSKRSRSLDSSSFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: TRUA_PELPD
Sequence: MRTIKLTIEYDGTNYAGWQVQPNGLAVQQVLEEALLRLLGERVRLRSSGRTDAGVHARAMVASFTTSRSLPLQAFVGGANRFLPDDIAILSAAEAAPEFRPIQDARSKWYRYTIYNAPVRSPLRRLFSWHVREPLDTDAMQLAAHHFPGRHDFAAFRASNCAAKTTLRRIDSVTIASEGELIVIDVIGEGFLKNMVRVMAGTLVDVGRGRFEPERVAWLLENPDRKKAGVTAPACGLCLMDVSY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: APAH_SHEB2
Sequence: MAHYFVGDIQGCFAELQKLLAKVDFNPSRDELWAVGDLVARGPDSLATLRFFRSLGDSAKTVLGNHDLHLMALHGKLKRTKPSDNLTEILESPDISASIDWLRQQPLMRELPEHQLIMSHAGVPPLWSLEVLREEAALVSCALKQDDYLEALISQMYSDSAEQWDPSAIGIERLRYCINALTRMRYLYVDGRLDFDCKQPPENCTNPQLKPWFEFASPLRQSHTLVFGHWAALMGNVGDSKLKALDTGCCWGEHLTLWHLEKDQKITQKKLKKS
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: CDII9_BURPE
Sequence: MAGSIVISKEVRVPVSTSQFDYLVSRIGDQFHSSDMWIKDEVYLPMEEGGMSFISTESLNSSGLSIFLATVMRARAASQAEESFPLYENVWNQLVEKLRQDARLGVSGN
What is the function of this protein?
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system.  CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion.  Neutralizes the toxic activity of cognate toxin CdiA (C-terminal 160 residue CT fragment) upon expression in E. coli.  Does not inhibit toxic activity of CdiA from other strains of B. pseudomallei.
What are the official names of this protein?
Immunity protein CdiI, CdiI-E479.
Protein: MTNB_BLAGS
Sequence: MSAIKDERNNDHLVQSHDPEHPANLIPALCRNFYGHGWVTGTGGGASIKRDNHIFIAPSGVQKELIQPHNIFVLQYPTPKYPPSARQYIRKPLELKPSACTPLFLAAFDRGAGCCIHTHSQWAVLVTLLVEREKGLEGCFEISNIEQIKGIPKGKGKGMMGFFDTLKIPIIENTAFEEDLTSSLEEAMEKYPDTYAVLVRRHGIYVWGDDVAKAKTQCESLDYLFQLAVEMHKLGLPWVKP
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SV2A_RAT
Sequence: MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEEDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKDREELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
What is the function of this protein?
(Microbial infection) Receptor for C. botulinum neurotoxin type F (BoNT/F) (PubMed:19476346, PubMed:19650874).  Binding requires glycosylation of Asn-573 (PubMed:19476346).
What are the official names of this protein?
Synaptic vesicle glycoprotein 2A, Synaptic vesicle protein 2, Synaptic vesicle protein 2A.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Presynapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. Colocalizes with ATP2B1 at photoreceptor synaptic terminals.
Protein: RNZ_PSEPG
Sequence: MDLLFLGTSAGVPTKARNVSATAVIETNGSHWYLVDCGEGTQHRLLHTPLSIRDLRAIFITHVHGDHCFGLPGLLASAGMSGRTQPLELILPVALHDWVRQGLVASDTFLPFELRLLAVEELAEWRNEALQVTTVQLSHRVPSVGFVFTELNPEPRLDTQRLQAEGIPRGPLWGELAKGLTVQHDGQLLDGHDYLRPSRPPRRVIVCGDNDNPELLADVAKGADVLVHEATFTQAVVERTGVTFGHSTAAAVARFAEGAGVRNLVLTHFSARYQSDPRRSPNIDNVRDEALAHYSGQLTLAQDLQRYHLGRDGCLEPVG
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RUVB_DEIRA
Sequence: MTAPENLDAALRPKTLTEYVGQEKLKDKLGVYLQAARGRREALDHTLLFGPPGLGKTTLAHIIAYELGVNIRVTSGPAIEKPGDLAAILTNSLEEGDVLFIDEIHRLGRVAEEHLYPAMEDFKLDIVLGQGPAARTIELPLPRFTLVGATTRPGLITAPMRSRFGIIEHLEYYTAEEIATNLLRDARLLGFGLDEEAGLEIGARSRGTMRIAKRLLRRVRDYADVAGETTIGLERAQSALDKLGLDSAGLDDRDKKYLETLIHRFAGGPVGVDTLATAISEDALTLEDVYEPYLIQLGFIKRTPRGRVATAHAYDHLGLPPGGIDDGNGIFLN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MTNA_SYNE7
Sequence: MSPFQSLLWTGSQLRLLDQRSLPQETQYRYYDTAAGVAQAIQDMVVRGAPAIGVAAAFGLVLTSQQSAMTDSADLRAQLAIAAETLKAARPTAVNLAWAVDRMLAAIANPDLEAAAIHATLLAAAQQLYDEDVAVNRQIGLNAQALIPQQANVIHHCNTGALATVDYGTALGIIRIAHEQGKQIHAYLDETRPRLQGANLSAFELQAYGVPHTVIVDGASGFLMRQQQIDCCLVGCDRVTANGDVANKIGTYNLALAAKAHGVPFYVACPISTIDRSLATGAEIEIEERDGREITEIRGQAIAPAGTKTWNPAFDITPAELVTAIITERGILYPPYGQALEQVLINPG
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.