PharMolix/UniProtQA huggingface dataset:
Protein: MUTS_ANASK
Sequence: MPEIAQAHTPMMRQYLETKARYPDAILFFRLGDFYEMFFEDALTASEALQITLTARSKGDDKVPMCGVPYHAARGYVARLLEKGFKVAICDQVEEPGKSQLVKREVTRVVTPGMVLDDQVLDPREASWLGAVALDDGRAGLALLDASTGQLQCGEVDGDERLVDELRRAGVRELVFSSAADGARAEAIARAVGAPAARRDAAEFERAEDRLRKHLGVPSLDGFGVSGLPLGLAAAAAALAYLADTQRAAPRHVDRISRLSTDDVLLLDEATRTNLELERTLSGGRKKGTLLALLDRTVTAPGGRRLAEWLRYPLTDLARIGARLDAVEELTGAAVAREELALALRPVADLERLLSRLVLGQGNARDLRALAGALLALPALAAVLEARGAARLREAGARLRGLEALAAHLDAAVAEEPPATLREGGIIRRGHSAELDEIVAIAEDGKGWIAALEAKERERTGIGSLKVRFNKVFGYYLEVTRPNLHLVPKDWERRQTTVGGERFVTPELKTLEEKVLTAEERRAALEERLFEALRQAVAAEAPRVRTAADAVATADALLSLSRVAAERGYVRPEVDASEALEIVDGRHPVVEAVLPDGPAAYVPNDVLVASRDAPECAEHGALLVITGPNMAGKSTVMREAALVVLLAQMGAFVPARRARIGLVDRIFTRVGASDDLARGRSTFMVEMTETAAILHNATRRSLVVLDEIGRGTSTFDGVSIAWAVAEHLHDVTGCRTLFATHYHELQDLARERPAVRNLTVAVREVGDRVVFLRKLVQGGASRSYGIEVAKLAGLPAEVLARAREILKNLEAMEVDEGGHPALARGRRRRAGPSAAQLGLFGGGAAADPAAEEVAKAIRAIDLDALRPLDALNLLAGWKKSLE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: SAP2_ARBPU
Sequence: CVTGAPGCVGGGRL
What is the function of this protein?
Causes stimulation of sperm respiration and motility through intracellular alkalinization, transient elevations of cAMP, cGMP and calcium levels in sperm cells, and transient activation and subsequent inactivation of the membrane form of guanylate cyclase.
What are the official names of this protein?
Resact, SAP-IIA, Sperm-activating peptide.
Protein: TRUD_METBU
Sequence: MNNVPNVEKQIGIDLYTTKTPGIGGKLRQQTEDFGVIEITNREEGTEGKYLILELTKRNWETHHLIRDLTRILRISQKRVGFAGTKDKRAVTTQKISIYDMEEEALQNVHLKDTELKILGRSNKSLELGDLTGNEFIITVRDIDLDEKELESRLSQTTASIKEQGGVPNFFGIQRFGALRPITHVVGESIVRNDIEKAAMAYIAASYPDEPEDTQEVRNRVFETKDYIEGLKGYPLQLRYERAMMHHLVSKPEDYAGSFETLPANIRKMFVHAYQSYIYNTIICSRIKKGLPLNRAVVGDIVCFKNKAGLPDKSRNERVTEDNIDGMNNLVKRNRAFVTAPLVGYSSELASGVPGEIEREVIEELNVPIEGFKVPSMEELSSKGLRREILLSTDPKYFIEEDELNEGKYRVTLDFSLPKGSYATTILREYMKVEPLKMS
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: VPS51_YEAST
Sequence: MAEQISHKKSLRVSSLNKDRRLLLREFYNLENEPNKGRQEARIGEKASEAHSGEEQVTDVNIDTEANTEKPVKDDELSATEEDLKEGSEDAEEEIKNLPFKRLVQIHNKLLGKETETNNSIKNTIYENYYDLIKVNDLLKEITNANEDQINKLKQTVESLIKEL
What is the function of this protein?
Involved in retrograde transport from early and late endosomes to late Golgi.  Links the Golgi-associated retrograde protein (GARP) complex to the t-SNARE TLG1, leading to the fusion between the endosomal vesicles with the late Golgi.  May also be indirectly involved in apical bud growth.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 51, Apical bud growth protein 3.
What is the protein family that this protein belongs to?
Belongs to the VPS51 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Protein: TPS1_DICPU
Sequence: MSLSLSDIKFPESWELIPNERNYIDYVYKESVELGVWRPDNKRDLIAHNNVVSLSKFFWPNMDFERLVMGGELMVWFFTFDDALDAGIYNDEQQAQVVKRMSDVFMNGTVEDDASGPEKMALHLRNKCEVMCGERKDTFNRFISSCIQWVDSIIPFNKIKIDGASPDIELYSYLRKINIGAFPCVTLTEVMLDHEIDHYVWYDPRWIKMNEDIAIITTLINDLVSYEKEVNDNAGDLNPLFFIQKQRKVPLTESFKEVVGLINHWVKDFTNLEESFMKSHKFKNSKQKRDFECMLEHLHYLASGSKLWSMQTPRYCSPTSPFIEMRKQSSSPNLTNSISIPTNNTNNSNNITSSPNKKQKIDITSSSAIFTTREIIN
What is the function of this protein?
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene protoillud-7-ene.
What are the official names of this protein?
Terpene synthase 1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: NFUA_PECCP
Sequence: MIRITDAAQEHFLKLLAKQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEASDTVLKFEKISAYVDELSAPYLEDAEIDFVTDQLGSQLTLKAPNAKMRKVDDSAPLMERVEYVLQSQINPQLAGHGGRVTLMEITDDGMAILQFGGGCNGCSMVDYTLKEGIEKELLEKFPELKGVRDLTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: G6PI_BURM7
Sequence: MTLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTDATLALLVRLAREAGVEARRDAMFAGETVNPTEGRAALHTALRANAPDAPFQAQVAAERAKMARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALHHVATPDIATHFVSNVDGADLARVLERIDPEETLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSANPAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFRTAPLERNLPVLQGLVGIWYRNFFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDGAFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIAVLTPEHPLASHHPKLLANCFAQSEALMLGRTLDEARKIAGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEHKVLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COPZ_STAHJ
Sequence: MINKVINVEGMSCDHCRNAVESALAKLNGVTSAEVDLDKNQVRVDYDENRVSVEQMKEAIEDQGYDVK
What is the function of this protein?
Chaperone that serves for the intracellular sequestration and transport of Cu(+).  Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA) (By similarity).
What are the official names of this protein?
Copper chaperone CopZ.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_SALSV
Sequence: MFTINAEVRKEQGKGASRRLRAANKFPAIIYGGSEAPIAIELDHDQVMNMQAKAEFYSEVLTLVVDGKEVKVKAQAVQRHAYKPKLTHIDFVRA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: GLNR_BACCR
Sequence: MKEDRRSAPLFPIGIVMDLTQLSARQIRYYEEHNLVSPTRTKGNRRLFSFNDVDKLLEIKDLLDQGLNMAGIKQVLLMKENQTEAVKVKEETKEISKTELRKILRDELQHTGRFNRTSLRQGDISRFFH
What is the function of this protein?
Transcription repressor during nitrogen excess.  On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site.
What are the official names of this protein?
HTH-type transcriptional regulator GlnR.
Protein: MUTS2_LACP3
Sequence: MNEKILKTLEYDKIQQALLGQVVTANGRQLVQAMQPLTDPVAVQQALDETADGASALRLKGGIPVPQLENIDPALKRVDIGAVLNGQELASISRVLQTVSAIDKFLTDLQDQIDFRQLYTLQESLTVLPQLSRRLKTAVDPDGTLTDEASPQLHGVREQIKSIEGEIRGKMTNYTRGAQSKYLSDPIVTIRDDRYVIPVKAEYRAKFGGVVHDQSATGQTLFIEPQAIVALNNRLREAQLAEVAEINRILAELSNELAPYTGQIKANAAVLGHFDFINAKARLAKAEKATEPLVSADNDVLLRDARHPLIDPHKVVGNDIPLGDKYQAMVITGPNTGGKTITLKTLGLLQLMGQSGLFIPADDESRIGIFDEVFADIGDEQSIEQNLSTFSAHMDNIVHILKQLSQNSLVLFDELGAGTDPQEGAALAIAILDAVGEVGAYVVATTHYPELKLYGYNTAKTINASMEFDSKTLQPTYRLLVGVPGRSNAFDISARLGLPGVIVERAKSMISSDSHELNNMISDLEKQRKAAETAYEAARRQLADAQSVHDELAAAYKKFTTERDAQLQQAKDKANTLVDKAQTKADKIIKQLRQMQLTNPGTVKENQLIAAKTALKQLHQDEPLQKNRILRREREKQALHVGDEVKVASYDQTGTLLEQFDKKHWQVQLGILKMKVPTDELKKIKSSKQSAAQRPVVKVSGGGMSGPSTTLDLRGERYDQAMADLDQYIDAALLAGYPSVTIIHGLGTGAIRNGVTQYLKRNRQVKTYGFAPQNAGGSGATIVNFK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: ISPH_ECO81
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDATDIQEEWVKEAKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRVDIREVD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: EASF_ASPFU
Sequence: MTISAPPIIDIRQAGLESSIPDQVVEGLTKEVKTLPALLFYSTKGIQHWNRHSHAADFYPRHEELCILKAEASKMAASIAQDSLVIDMGSASMDKVILLLEALEEQKKSITYYALDLSYSELASNFQAIPVDRFHYVRFAALHGTFDDGLHWLQNAPDIRNRPRCILLFGLTIGNFSRDNAASFLRNIAQSALSTSPTQSSIIVSLDSCKLPTKILRAYTADGVVPFALASLSYANSLFHPKGDRKIFNEEDWYFHSEWNHALGRHEASLITQSKDIQLGAPLETVIVRRDEKIRFGCSYKYDKAERDQLFHSAGLEDAAVWTAPDCDVAFYQLRLRLN
What is the function of this protein?
4-dimethylallyltryptophan N-methyltransferase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid (PubMed:15933009, PubMed:23435153, PubMed:26972831).  DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:15870460).  The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity).  The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by EasD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:20039019, PubMed:20526482, PubMed:21409592).  EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:20526482).  EasG then catalyzes the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:20526482).  Hydrolysis of festuclavine by easM then leads to the formation of fumigaclavine B which is in turn acetylated by easN to fumigaclavine A (PubMed:26972831).  Finally, easL catalyzes the conversion of fumigaclavine A into fumigaclavine C by attaching a dimethylallyl moiety to C-2 of the indole nucleus (PubMed:19672909).
What are the official names of this protein?
4-dimethylallyltryptophan N-methyltransferase easF, 4-dimethylallyltryptophan methyltransferase, Ergot alkaloid synthesis protein F.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: PDS5A_RAT
Sequence: MDFTQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDCNEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHKNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDPHLLLSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVNDQLLGFVRERTLDKRWRVRKEAMMGLAQLYKKYCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANPKQPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDSAIRSGLELLKVLSFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAVHCIHAIFSNKEVQLAQIFEPLSRSLNADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIKLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDEAKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFSNDKSYISEETRVLLLTGKPKPTGVLGTVNKPLSATGRKPYVRSAGTETGSNINASSELSPSAGNRSREQSSEASETGVSENEENPVRIISVTPVKSIDTVKNKEINSDQSTQGNISSDRGKKRIVTAAGAENIQQKPDEKADESGPPAPSKPRRGRRPKSESQGNATKNDDLSKPVSKGRKRAAGSQESLEAGNAKAPKLQDGAKKAVPAERQIDLQR
What is the function of this protein?
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin.  May couple sister chromatid cohesion during mitosis to DNA replication.  Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).
What are the official names of this protein?
Sister chromatid cohesion protein PDS5 homolog A.
What is the protein family that this protein belongs to?
Belongs to the PDS5 family.
What are the subcellular locations of this protein?
Nucleus. Note=Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase (By similarity).
Protein: CMPDT_BUCAI
Sequence: MPANNSLLIFRDEINNIDKKIVKLLAERKNLVFKIAQSKIENNQAIRDIEREKKMLQKLIFLGKKYNLKSEYITQLFQLIIEESVATQKKLLKKFCNHNKLIPANFSFLGPKGSYSHIAAYKYADLNFQKCITNECSTFEEVVLSVENNQSDYAVLPIENTCSGSINEVFDILKKTNLFIIGEINIFINHNLLTLKKIELNKIKTIYSHPQPFQQCSDFIKKFPEWKIKYTKSTADAMKKIKKYNDVTNAALGSEIGSKIYGLEILMKNLANKENNITRFILLNRNPKKISKNIPTTTTLIFTTGQEAGSLSKVLSILQEKKLIMKKLTSQKIYKNPWEEMFYIDIQVNLSSTLMQDALEKIKKITRFIKILGCYPSEKITPIAP
What is the function of this protein?
Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
What are the official names of this protein?
Bifunctional chorismate mutase/prephenate dehydratase, Chorismate mutase-prephenate dehydratase, P-protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_AGRVS
Sequence: MTAITDIIAREILDSRGNPTVEVDVYLEDGSMGRAAVPSGASTGAHEAVELRDGGKRYLGKGVEKAVEAVNSEIYDAIGGHDAENQIQIDTIMRELDGTPNKSRLGANAILGVSLAVAKAAAEASGLPLYRYVGGPNARILPVPMMNIINGGAHADNPIDFQEFMIMPVGADNIRDAVRMGSEVFHTLKKELSAQGFNTNVGDEGGFAPGLKSAPEALDFIMKSIEKAGYRPGEDMYLALDCASTEFFKDGKYVLEGEGRTLEPEAMAEYLAELAAKYPIISIEDGMGEDDWDGWKYLTDKIGATTQLVGDDLFVTNSARLRDGIRMGVANSILVKVNQIGSLSETLDAVETAHKAAYTAVMSHRSGETEDSIIADLSVATNCGQIKTGSLSRSDRLAKYNQLIRIEELLGPQAAYAGTSILKA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: FRD_BPT5
Sequence: MITAMYAVGPNGEFGLRGKLPWGSFKEELDAFYSQLDVLNPDNIIIGAGTYLALPYAVRERMIGASDLFIRADRPLPDDITHDIYTPISMIGDTLPTFLKDQQTVVLGGANLLLEMYQHGHIESAFVSTIFSEQKLEADTHLDSMILDYNYESTRLVYAVGANSDNSLRFVQELVTY
What is the function of this protein?
Provides the tetrahydrofolates necessary for the synthesis of nucleotides and amino acids.  Bacteriophage T5 induces high levels of dihydrofolate reductase in the host cell, probably for the viral replication.
What are the official names of this protein?
Dihydrofolate reductase.
Protein: H2A2_PSAMI
Sequence: MSGRGKGAKAKSKAKSRSSRAGLQFPVGRVHRFLKKGNYGNRVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKSRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQTVLLPKKTGKSA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Late histone H2A.2.1.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SIAL_PIG
Sequence: FSMKNFHRRAKLEDPEENGVFKYRPRYYLYKHAYFYPPLKRFPVQSSSDSSEENGNGDSSEEEEEEEENSNEEENNEENEDSDGNEDEDSEAENITLSTTTLGYGGDVTPGTASIGLAALQLPKKAGDIGKKSAKEEESDEDEEEEEENEENEAEVDDNEQGTNGTSTNSTEVDSGNGHSGGDNGEEGDQESVTEAQGTTVAGEQDNGGAKTTTSPNGGLEPTPPPQDISGTTLPPSGKTTTPEYEGEYEQTGAHEYDNGYEIYESENGEPRGDSYRAYEDEYSYYKGRSYNSYGGHDYY
What is the function of this protein?
Binds tightly to hydroxyapatite.  Appears to form an integral part of the mineralized matrix.  Probably important to cell-matrix interaction.  Promotes Arg-Gly-Asp-dependent cell attachment.
What are the official names of this protein?
Bone sialoprotein 2, Bone sialoprotein II, BSP II, Cell-binding sialoprotein, Integrin-binding sialoprotein.
What are the subcellular locations of this protein?
Secreted.
Protein: RRG8_YEAS2
Sequence: MGLPKSAYKKLLIDCPTRVINKNCAQRVKDVSPLITNFEKWSDKRKKLYFKDEEEMVGHFHLENFNLKNNLYGRLLASPMRAEKISKLKSCRELLIPLKVVPSTGKDQHADKDKLKLVPTLDYSKSYKSSYVLNSASIVQDNLAAATSWFPISVLQTSTPKSLEVDSSTFITEYNANLHAFIKARLSVIPNVGPSSINRVLLICDKRKTPPIEIQVVSHGKGLPITQSVFNLGYLHEPTLEAIVSKDAVTKGIYLDADNDKDLIKHLYSTLLFQSVN
What is the function of this protein?
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
What are the official names of this protein?
Required for respiratory growth protein 8, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG8 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HSOP_PLAFA
Sequence: MVNKEEAQRLKELGNKCFQEGKYEEAVKYFSDAITNDPLDHVLYSNLSGAFASLGRFYEALESANKCISIKKDWPKGYIRKGCAEHGLRQLSNAEKTYLEGLKIDPNNKSLQDALSKVRNENMLENAQLIAHLNNIIENDPQLKSYKEENSNYPHELLNTIKSINSNPMNIRIILSTCHPKISEGVEKFFGFKFTGEGNDAEERQRQQREEEERRKKKEEEERKKKEEEEMKKQNRTPEQIQGDEHKLKVMN
What is the function of this protein?
Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90.  Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity.
What are the official names of this protein?
Hsp70-Hsp90 organising protein, PfHOP, Stress-inducible protein 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANGI_RABIT
Sequence: QDDSRYKHFLTQHYDAKPFGRNDRYCETMMKRRDLTSPCKDTNTFVHGNKGSIKDVCEDKNGKPYGKNFRISKSSFQVTTCKHVGGSPWPPCRYRATSGSRNIVIACENGLPVHFDESVFQQKVH
What is the function of this protein?
Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity).  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus (By similarity).  3Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA (By similarity).  Angiogenin induces vascularization of normal and malignant tissues (PubMed:8448182).  Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity).
What are the official names of this protein?
Angiogenin, Ribonuclease 5, RNase 5.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: VN1R4_HUMAN
Sequence: MASRYVAVGMILSQTVVGVLGSFSVLLHYLSFYCTGCRLRSTDLIVKHLIVANFLALRCKGVPQTMAAFGVRYFLNALGCKLVFYLHRVGRGVSIGTTCLLSVFQVITVSSRKSRWAKLKEKAPKHVGFSVLLCWIVCMLVNIIFPMYVTGKWNYTNITVNEDLGYCSGGGNNKIAQTLRAMLLSFPDVLCLGLMLWVSSSMVCILHRHKQRVQHIDRSDLSPRASPENRATQSILILVSTFVSSYTLSCLFQVCMALLDNPNSLLVNTSALMSVCFPTLSPFVLMSCDPSVYRFCFAWKR
What is the function of this protein?
Putative pheromone receptor.
What are the official names of this protein?
Vomeronasal type-1 receptor 4, G-protein coupled receptor GPCR27, hGPCR27, V1r-like receptor 4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLYCO_IHNVW
Sequence: MDTMITTPLILILITCGANSQTVKPDTASESDQPTWSNPLFTYPEGCTLDKLSKVNASQLRCPRIFDDENRGLIAYPTSIRSLSVGNDLGDIHTQGNHIHKVLYRTICSTGFFGGQTIEKALVKMKLSTKEAGAYDTTTAAALYFPAPRCQWYTDNVQNDLIFYYTTQKSVLRDPYTRDFLDSDFIGGKCTKSPCQTHWSNVVWMGDAGIPACDSSQEIKAHLFVDKISNRVVKATSYGHHPWGLHQACMIEFCGQQWIRTDLGDLISVVYNSGSEILSFPKCEDKTVGMRGNLDDFAYLDDLVKASESREECLEAHAEIISTNSVTPYLLSKFRSPHPGINDVYAMHKGSIYHGMCMTVAVDEVSKDRTTYRAHRATSFTKWERPFGDEWEGFHGLHGNNTTIIPDLEKYVAQYKMSMMEPMSIKSVPHPSILALYNETDVSGISIRKLDSFDLQSLHWSFWPTISALGGIPFVLLLAVAACCCWSGRPPTPSVPQSIPMYHLANRS
What is the function of this protein?
Binds to specific receptor at cellular surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the viral nucleocapsid into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in G, releasing a fusion hydrophobic peptide (By similarity).
What are the official names of this protein?
Glycoprotein, Spike glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the novirhabdovirus glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: THIE_LYSSC
Sequence: MKREDLQLYFIMGTSNVSHQEPLVVLEKALRAGITMFQLREKGPYALTGLAYEQFARQCQQLCQHYHVPFIVNDDVDLAVRLGADGVHIGQDDEQIAIARKKMANRILGVSVHSQEELQIAIDHHADYVGIGPIFATTSKSDAQPPCGTNFLQQASKLQPNLPIVAIGGINGINADIVFQAGADGVAVISALCESEDIEQTVSIFKSLNRIKR
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.