PharMolix/UniProtQA huggingface dataset:
Protein: FPG_CERSK
Sequence: MPELPEVETVRRGLEPAMAGRLIAEARVNRADLRWPFPPRMAERLTGQRVLRLRRRSKYILADLSGGQSLLIHLGMSGRMLVSGAQLGEFFHDHPAPSRHDHVVLEMEGGARITFNDARRFGAMDLVATEAAEAHPLLAVLGPEPLGNAFDGAYLAARLEGRRTPIKAALLDQRIVAGLGNIYVCEVLFRAGLAPGRLAGSLSRAESEGLVPLIREVLLEAIEAGGSSLRDYRQADGELGYFQHTFRVYGREGLPCVTPGCSGTVGRIVQSGRSSFHCPLCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: CAPC_BACAN
Sequence: MFGSDLYIALVLGVTLSLIFTERTGILPAGLVVPGYLALVFNQPVFMLVVLFISILTYVIVTYGVSRFMILYGRRKFAATLITGICLKLLFDYCYPVMPFEIFEFRGIGVIVPGLIANTIQRQGLPLTIGTTILLSGATFAIMNIYYLF
What is the function of this protein?
Essential for the synthesis of the polyglutamate capsule of B. anthracis which is one of the principal virulence factors during anthrax infection.  May form a polyglutamyl synthetase complex together with proteins CapA and CapB.  CapC may be the endogenous acceptor of glutamyl residues.
What are the official names of this protein?
Capsule biosynthesis protein CapC.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLIF_PSEAE
Sequence: MADALIDSQVPAKSGGAGMLKKSFPGLSFLDNLSEMTMLRQIGLLVGLAASVAIGFAVVLWSQQPDYKPLYGSLNGVDANRVVEALTAADIPYKVEPNSGALLVKADDLGRARMKVASAGVAPTDNNVGFEILDKEQALGTSQFMEATNYRRGLEGELARTVSSLNNVKAARVHLAIPKSSVFVRDDRKPSASVLVELYPGRSLEPSQVMAIVNLVATSVPELDKSQVTVVDQKGNLLSDQQELSELTMAGKQFDFTRRMEGLLTQRVHNILQPVLGNGRYKAEVSADVDFSAVESTSEMYNPDQPALRSEQRNNEERQNSSGPQGVPGALSNQPPGPASAPQQATASAPADYVAPGQPLKDANGQTIIDPKTGKPELAPYPTDKRDQTTRNYELDRSISYTKQQQGRLRRLSVAVVLDDQMKVDAKTGEVSHQPWSADELARFTRLVQDSVGYDASRGDSVSVINAPFAPAQAEEIDSIPFYSQPWFWDIVKQVLGVLFILVLVFGVLRPVLSNITGGGKGKSLAGGGGRDGDLALGESGLEGSLADDRVSIGGPSSILLPSPTEGYDAQLNAIKNLVAQDPGRVAQVVKEWINADE
What is the function of this protein?
The M ring may be actively involved in energy transduction.
What are the official names of this protein?
Flagellar M-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FliF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Protein: ATP6_RICTY
Sequence: MTNSPLIQFNIKKLIDIKMFGLDVSFTNSSIYMLLASTLALTYFYLAFYNRKLIPSRLQVSAEIVYNFVVDMLNQNIGIKGRKFIPLVFSLFIFILFCNLLGMTPYSFTATSHIIVTFTLALLIFLTVTIVGFIKHGMSFLTLFLPQGTPVWLAPLMIVIELFTYLAKPVSLSLRLAANMMAGHVLLKVIAGFTVSLMIYLKFLPIPLIVILIGFEIFVAILQAYIFTILSCMYLNDAINLH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GCSP_PSYA2
Sequence: MTISQNPTLDTFKGLFNEAEFVYRHLGSNDAKQADLLSAIGYKDMATFINDTVPEPVRLHKELDLPVAMSEHAALAKLRTMADDITVNKSYIGQGYSPVRMPAVIQRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGLELAGASLLDEATAAAEAMAMSKRVSKSKSMQFFVDDRVYSQTLDVINTRAKYFGWEVVVGDFELAKSGDYFGALFQYVGVEGDVKDLTDVIAAVKKNKTYVNVVSDIMSLVLLKSPADMGADVALGSTQRFGIPMGFGGPHAAYFAFSDKAKRSAPGRIIGVSKDSQGNTALRMALQTREQHIRREKANSNICTSQVLLANLAGMYAVYHGPGGVKRIATRIHAFATAFADVIKNANDSNLNVVHDQFFDSVVIDCGSEKLATQIFENADNVGYNLWRLGDSKLSVAFSETSDQEDFKILTQLFVTKAHDLPEDARISLDSTHLRTDDILTHPVFNSHHTEHEMLRYLKSLEDKDLAMNRSMISLGSCTMKLNATSEMLPITWPEFANVHPFAPRDQVTGYVAMIDSLQEQLKAITGFDDVSMQPNSGASGEYAGLLAIRRYHESLGETDRDVCLIPMSAHGTNPATAMMMGMKVVVVKTDDNGNVDIDDLTAKSEEHSARLGALMITYPSTHGVFEEGIRKICDLIHKHGGQVYMDGANMNAQVGMMQPADVGADVLHMNLHKTFCIPHGGGGPGMGPIGMKSHLAPFMANHTLSPVHNAQKDCSAVSAAPYGSASILPISWMYIAMMGRDGLLKATELALLNANYVAAELKDYYPVLYTGKNGRVAHECIIDIRPLKEETGISESDIAKRLMDYGFHSPTMSFPVAGTLMIEPTESESKEELDRFISALKSIKAEAMKAKAGEDNWTLENNPLVNAPHTAAMVIDGEWTYPYSRETAAFPLPYIRTNKFWPSVARVDDAYGDKNLMCSCPSIENYM
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: SCPA_LACLS
Sequence: MIKEINIKIKNFEGPLDLLLHLVSQYEMDIFEVPLVPVIEQYLIYIQTMKELELELAGEYMLMASQLMLIKSRRLLPTVTETFIEDTEQLEYDLLAQIDEYRKYKMLSEDLDELHQERSHYYSKSKTEIITDETVLLQDKTALDLFLAFSKILELQRQQIEDDNTTIAAEKFTIADKIFELNQRFTEQKICKFTDLFSDKTKKDELVTTFMALLELIKNQQVSFSQGELFGEIILERKEISE
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: ARLY_LACPL
Sequence: MSTQKLWGGRFTETGAKYVDDFGASISFDQLLAAEDIAGSLAHVKMLKKTGILPAADVDQIVAGLETLAERQKQGELEFSTVNEDIHMNIESLLTEEIGPVAGKLHTARSRNDQVATDFHLYLKHQLPLILDRLHELETVLVDKASENVETVMPGYTHLQHAQPISYAHYLLAYYQMFKRDMERFEFNLKHTDISPLGAAALAGTTFPIDREYSAKLLGFSEVYHNSLDAVSDRDFVLEFLSNASILMMHLSRFCEEIVSWSSYEFKYISLSDQFSTGSSIMPQKKNPDMAELIRGKSGRVYGNLMGLLTVMKGIPLAYNKDLQEDKEGAFDTVTTVLTSLHVFTGMLATLTVNEDRMADATTNDFSNATELADYLANKGIPFREAHAIVGKLVLDGLKKQRPLQDIPLKEYQSISPLIQEDVYHDLNAKVAVERRHSLGGTGFDQIRQELQRAQTQLSAYQSETTD
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURQ_LACGA
Sequence: MEIKNLTTEQRNPATMHIDSMSTIDMVKTINKEDQKVAVAVGTQDDKIAQAIDEAAKRYSKGGRLIYIGAGTSGRLGVLDAAELVPTYGIKPERAIGLIAGGKGAMYVAVEGAEDSQDLAKRDLKDLKLNKNDIVLGLAASGRTPYVIGGLDYAKAIGALTISIACVKDSKIGHHADIAIEAVVGPEAITGSTRMKAGTAQKMILNMISTGVMIKQGKVFENVMIDVKPTNSKLIDRACRIIQTTTGVSTPEARNTLEKANNDVGLAIVMLKTNSDLNQAKNLLKAENGNVAEVLNK
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: RIMKB_DANRE
Sequence: MCSRVWFITDRRISQEYPQIQILRALKERCVEDDVEFRYLLMDEIVLTITDGQLGLRVGQEIVTSYPQVAVVRVPTPWVQSDSDITVLRHLEKMGCRLVNRPQAILNCVNKFWTFQELAGHGVPLPDTYSYGGHDNFRKMIDEAEPLGYPVVVKNARGHRGKAVFLARDKHHLSDLCHLIRHEAPYLFQEYVKESHGRDVRVVLVGGRVIGSMLRCSTDGRMQSNCSLGGVGMMCPLSEQGKQLAVQVCNILGMDVCGIDLLQKNDGSFVVCEANANVGFIAFDQACGMDVAGIVADFVLSLLPSRLSRKMSLLSVVSSTSETSSEPEVCIPTEVIIPSEVCIPNEICPLGTTCPIPDAMSTMSTSSTSSESEADLTETGPTPVGANPAYNINSLLASEMKLLTE
What is the function of this protein?
Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate.  Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate.
What are the official names of this protein?
Beta-citrylglutamate synthase B, N-acetyl-aspartylglutamate synthetase B, NAAG synthetase B, NAAGS, Ribosomal protein S6 modification-like protein B.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANRA2_HUMAN
Sequence: MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE
What is the function of this protein?
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541).  May also regulate LRP2/megalin (By similarity).
What are the official names of this protein?
Ankyrin repeat family A protein 2, RFXANK-like protein 2.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.
Protein: CYAA_GLUNI
Sequence: MSTEHTNTPRADSPQSAAEAVRGARQHAPAATPAESDPILELAEAMEGPLRIPAHTPEAVRDTVASLEKRLIGGQREFRRREVASEAGVSLHSARKLWRAIGFPELSDDEVFFTEADKKALGTMVGMVREGALTEETAISLMRSVGQMTDRMVVWQIEALVEDMIANQNLSDRQARRQLFSLLPEIIPAIEDLLLYSWRRQLNSAVHRMALRVETGVAAYNQDRGEDDGGTPLPLARAVGFADLVSYTSLSRRMNERTLAQLVQRFEAKCAEIISVGGGRLVKTIGDEVLYVAETPQAGAQIALSLSRELAKDELFPQTRGAVVWGRLLSRLGDIYGPTVNMAARLTSLAEPGTVLTDAITANTLRNDARFVLTAQEITAVRGFGDIQPYELSAGEGAGLVID
What is the function of this protein?
Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
What are the official names of this protein?
Adenylate cyclase, ATP pyrophosphate-lyase, Adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_CAUVN
Sequence: MIGLPHYLVVAAILFTIGVFGIFVNRKNVIVILMSIELILLAVNINLVAFSAYLHDVAGQIFAMFVLTVAAAEAAVGLAILVTFFRNRGDIAVDDASMMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YCDX_SHIFL
Sequence: MYPVDLHMHTVASTHAYSTLSDYIAQAKQKGIKLFAITDHGPDMEDAPHHWHFINMRIWPRVVDGVGILRGIEANIKNVDGEIDCSGKMFDSLDLIIAGFHEPVFAPHDKATNTQAMISTIASGNVHIISHPGNPKYEIDVKAVAEAAAKHQVALEINNSSFLHSRKGSEDNCRAVAAAVRDAGGWVALGSDSHTAFTMGEFEECLKILDAVDFPLERILNVSPRRLLNFLESRGMAPIAEFADL
What are the official names of this protein?
Probable phosphatase YcdX.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: MIAB_NITEC
Sequence: MSSKLYIKTFGCQMNEYDSAKMADILLSEKNMELTEVPEEADLILFNTCSVREKAQEKVFHDLGRVRHLKNSKPDLLIGVGGCVASQEGSEIVRRAPFVDLVFGPQTLHRLPELIDARRRTGQSQVDITFPEIEKFDRLPPARTTGATAFVSIMEGCSKYCSFCVVPYTRGEEVSRPLDDVLTEVAGLVIQGVKEVTLLGQNVNAYYDKTSGEGDIDFATLLDYIHEIPGLVRIRYTTSHPREFTARLIETYQRLPKLVGHVHLPIQSGSDRILAAMKRGYTIIEYKSIIRKLRTIRPNISISSDFIVGFPGETDTDFEETMKLIDDVKFDESFSFIYSPRPGTPASDLPDDTPYRIKLARLHQLQEKIQRNAQMISQSMVDTIQRVLVEGPSKKDPNEFCGRTDNNRVVNFAGHAGLVGSFVDIKITAVSSHTLRGEISDMQ
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_ECOBW
Sequence: MKFELDTTDGRARRGRLVFDRGVVETPCFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGNKNALFGIIQGSVYEDLRDISVKGLVDIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKYKSDTGPLDPECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PDXS_META3
Sequence: MKKIGTELLKRGFAKMVKHGVVMDVTNPEQARIAEDAGAAAVMALERVPADIRAEGGVSRMSDPEMILEIKDEVSIPVMAKARIGHFVEAQALESLGIDMVDESEVLTPADEIHHIDKNAFDIPFVCGARNLGEALRRIDEGAAMIRTKGEAGTGDVIEAVKHMRAVNEGIAKVVGYYEMGCDRELVQMARNELKVPMDLVYEVAELKRLPVVNFAAGGIATPADAALMMQLGCDGVFVGSGIFKSGNPEERARAIVEATYNYDKPDVIAEVSKNLGEAMVGINVDAIPEKELLAKRGI
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: CLAVA_STYCL
Sequence: MKTTILILLILGLGINAKSLEERKSEEEKVFQFLGKIIHHVGNFVHGFSHVFGDDQQDNGKFYGHYAEDNGKHWYDTGDQ
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Clavanin-A.
What are the subcellular locations of this protein?
Secreted.
Protein: IF3_STRU0
Sequence: MKIIAKKDLFINDEIRVREVRLVGLEGEQLGIKPLSEAQAIADAANVDLVLIQPQAVPPVAKIMDYGKFKFEFQKKQKEQRKKQSVVTVKEVRLSPVIDKGDFETKLRNGRKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKMDGRQMFMQLAPISDKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRTFA_XENLA
Sequence: MTLLDTEQALLAIHTVLQLKLQQRRTREELENQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERAELVRMHILEETSAEPSLQAKQIKLKRARLADDLNEKISQRPGPMELVVKNILPVETSLKEVIIDVDYPEVVDNSSFDEDSSDALSPEQPASQESQGSIPSPIENRPSETTQIPALSPSHAFSCVQFGTDAFNQDSLQSTAITISNGLTASICKSLPALVKQSQPKPSFEKSQRIKKPKEPKPKVKKLKYHQYIPPDQKQKGTPAMDSSYAKLLQQQQLFLQLQIINQQQHQHYNYQTILPAPPKPLPDQQNTNSSSTTTVRSMSTVAPSTLATPTITRQNSNVAVGGRTGPLPHNLDEMKVAELKLELKHRGLPVSGTKIDLIERLKASQDPSTATAASAKPTPVQQAKPPEVVPIVSSSCLTTREPIKLCSTSSTPPGSPCPSEVSVVSMDEVSMISDALGETVACPVTQQVQQNPAAEKSPPDARDKDLMLREKDRQIEELTQRLKQKQELVERLRQQLEQEKRTPQHSTDDQQALILAVKQEPLPLTVDSINKKASSIVKQELNTAIICQQEPQLLIGPVSSGIEGKVDNSAGTKLVFTLTNPSSQLPEENRQIVLQKVPTPPSSLHPNNSLPKQEVLLSCCALQNQKPALQLVPGTVLSLSSSNLQPMLNMNGFQKWHGEALDSLQKQLVHNESPATPPQQPEPEPPPHSIFLTHSSPQWSKNPPGYDEAMKQQPNSCEDGRPGCLQAVDFFDVLIKNLDIPSEFKDYLVPCLKQTSPSHQAAQMVPQVEMAPPPSPIHSALGRLEDFLESSTGTPLLRGHQDGPSSMPLIDDLHSQMLSSLAILDHPPSPMDTSDLHFSPIGNSLGLDISEPPLDGMDWLELSEPPAMNLTPLSTFTPSVFSTDFLDSHDLHLHWDSCL
What is the function of this protein?
Transcription coactivator that associates with the serum response factor (srf) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration.  The srf-mrtfa complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics.  Mrtfa binds G-actin via its RPEL repeats, regulating activity of the mrtfa-srf complex.  Activity is also regulated by filamentous actin (F-actin) in the nucleus.
What are the official names of this protein?
Myocardin-related transcription factor A, MRTF-A, MKL/myocardin-like protein 1, Megakaryoblastic leukemia 1 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Subcellular location is tightly regulated by actin both in cytoplasm and nucleus: high levels of G- actin in the nucleus observed during serum deprivation lead to low levels of nuclear mrtfa, while reduced levels of nuclear G-actin result in accumulation of mrtfa in the nucleus.
Protein: RL27A_PANTR
Sequence: MPSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGLHHHRINFDKYHPGYFGKVGMKHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPIIDVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKSVGGACVLVG
What are the official names of this protein?
60S ribosomal protein L27a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PPNP_ECO57
Sequence: MLQSNEYFSGKVKSIGFSSSSTGRASVGVMVEGEYTFSTAEPEEMTVISGALNVLLPDATDWQVYEAGSVFNVPGHSEFHLQVAEPTSYLCRYL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: CNMD_RABIT
Sequence: MTENSDKVPIALVGPDDVEFCGPPAYATVTVKPSGPARLLKVGAVVLISGAVLLLFGAIGAFYLWKGSDNHIYNVHYTMSINGKLQDGSMEIDARNNLETFKMGSGAEEAIEVNDFQNGITGIRFAGGEKCYIKAQVKARVPEVGTVTQQSISSELEGKIMPVKHEEEALVWVAVGQPVQDNSFLSARVLELCGDLPIFWLKPTYPKEIQRERREVVRKTVPTTTKRPHSGPRGNPGPARMRNDSRPSVQEDSEPFNPDNPYHQEGESMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYNPWPYNYQGCRSACRVVMPCSWWVARILGMV
What is the function of this protein?
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells.  May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.  Inhibits in vitro tube formation and mobilization of endothelial cells.  Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity).
What are the official names of this protein?
Leukocyte cell-derived chemotaxin 1, Chondromodulin.
What is the protein family that this protein belongs to?
Belongs to the chondromodulin-1 family.
What are the subcellular locations of this protein?
[Chondromodulin-1]: Secreted, extracellular space, extracellular matrix. Note=Accumulated in the inter-territorial matrix of cartilage. SUBCELLULAR LOCATION: [Chondrosurfactant protein]: Endomembrane system; Single-pass membrane protein.
Protein: RECA_LISIN
Sequence: MNDRQAALDQALKQIEKQFGKGSIMKLGEHSDQNISTISSGSLALDIALGVGGYPRGRIIEVYGPESSGKTTVALHAIAEVQAQGGTAAFIDAEHALDPAYAKNLGVNIDELLLSQPDTGEQALEIAEALVRSGAVDMLVIDSVAALVPRAEIEGEMGDAHVGLQARLMSQALRKLSGVINKSKTIAIFINQIREKVGVMFGNPEITPGGRALKFYSTVRLEVRRAEQLKQGTDVMGNKTKIKVVKNKVAPPFRIAEVDIMYGEGISREGELVDMAAEVDVINKSGSWYSYKEERIGQGRENAKQYLKEHTDIRDEISKRVREEYEIDGTNKEPLDENEETLSLLDDE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_LEIXX
Sequence: MTDTTAQHVVDTVANAAATPEREQPFAALGLKPDEYASIREILGRRPTNGELAMYSVMWSEHCSYKSSKIYLRQFGQKVTPAMKKNLMVGMGENAGVVDIGEGWAVTFKVESHNHPSYIEPFQGAATGVGGIVRDIISMGARPVAVMDQLRFGAIDEPDTAHVVHGVVSGISFYGNCLGLPNIGGETYFDPVYQGNPLVNALSVGVLRHEDLHLANASGVGNKVVLFGARTGGDGIGGASILASDTFSEGGPTKRPAVQVGDPFAEKVLIECCLELYRDKLVEGIQDLGAAGISCATSELASNGDGGMFIELDSVLLRDPSLTAEEILMSESQERMMAVVKPELLDQFLAVTAKWDVETSVLGEVTGTGRLVINWHGEEIANVDPRTVAIDGPVYERPVAYPSWIDALRADSASALALPVSGDALREQALALLGSANLADKSWITDQYDYFVGGNTALAFPDDAGMIRVDEESGLGFAIATDANGRYCQLDPKEGAKLALAEAYRNVAASGAVPAAVTDCLNFGSPENPEVMWQFSQAVEGLSDACLELGIPVTGGNVSFYNQTGDVPIFPTPVVGVLGVIDDVARRIPAGWQDEGENIYLLGITREELDGSAWAATVHGHLGGRPPAVDLAAERRLAETLHAASQQGLISSAHDLADGGLAQALTESVLRFGVGARVWLGDIAERDGVDAASALFSESTARAIVSVPREDDVKFRGLCDGRGVPALRIGVTDAGAGTEPVLEIQDLFAIEVAELRSVHRSTLAERFGPVVG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.