PharMolix/UniProtQA huggingface dataset:
Protein: RS18_HELMI
Sequence: MQDRGDKPERRSRKGRRPRRRICFFCVDKIETVDYKEVGKLRKYITERGKILPRRVSGCCAKHQRQLTNAIKRARHVALLPFTVNE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: SYS_RHOCS
Sequence: MHDLRAIRDNPEAFDTGLARRGLPPASAAILDLDQRRRAAQTSFQECQARRNEASRLIGAYKKDGKDAQPLLDEVAALKERIPALEEEDRRLGAELDALLAALPNLPAADVPEGKDEHDNVEIRRVGTPRDIPGAKQHFELGEALGLMDFEGAARMSGARFTVLKGQLARLERALGDFMLDLHTREFGYTEVSPPLLVRDEAVFGTGQLPKFADDLFRTTTGHWLIPTAEVTLTNLANDSIIDAEALPWRLTARTPCFRSEAGSAGKDTRGMIRQHQFMKVELVSITLPEQSEAEHERMTKAAETVLERLGLPFRTVVLCTGDMGFSARKTYDIEVWLPGQGAYREISSCSNCGDFQARRMKARSRPKGEKGTQVVHTLNGSGVAVGRALIAVMENYQQPDGSILVPEALRPYMGGQERITAHG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNPA_STRCO
Sequence: MRITLPLLSTAVGLGLTAAVLGTGPAATAAAPQEPVRAAQLGYQPSAGSGEDAAANRAFFEAVVKSVAEKRAANPSAAAAVTVYYSATNAPSFRSQISRSAQIWNSSVSNVRLAESSSGADFAYYEGNDSRGSYASTDGHGSGYIFLDYRQNQQYDSTRVTAHETGHVLGLPDHYSGPCSELMSGGGPGPSCTNPYPNSTERSRVNQLWAYGFQAALDKALEKASQR
What are the official names of this protein?
Extracellular small neutral protease, Extracellular metalloprotease, Snapalysin.
What is the protein family that this protein belongs to?
Belongs to the peptidase M7 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLR27_PLAVT
Sequence: MTNLFTRHTRRSLTALALLSGGVYAADEVNAKILSRSLRVFVTGGQVLWDYRIHFKGIERDHPDYHSKLQSLNQRIAHRLLYLCFENGGIYTKFGQQLATFNHGLPREYTMTLAQLQDQAKPVSFDKVKQTIEAEMGRPWNECYKEFDQTPIASASLAQVHHAVDALGREMAVKVQYPHLELQMKADIRVIKWAFQFTEYCFPDVQLQWLFPEFQKALLAEVHFDAQCTALLIIF
What is the function of this protein?
Effector that acts as a broad suppressor of cell death to interrupt plant immunity.  Inhibits cell death induced by cell death-inducing proteins, including the PAMP elicitor INF1 from P. infestans.
What are the official names of this protein?
Secreted RxLR effector protein 27.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus.
Protein: FABV2_VIBCH
Sequence: MHIKPIIQGVVARSAHPYGCEQAVLQQIQYVKQANPIKSGPKRVLILGASSGFGLAARIALTFGGAQADTIGVSFERAPSETQTGSAGYYNNLFFKQHAEQAGRIAVNLEGDVFSVDMREQVIEAIETYFEGEVDLIIYSIASGMRRKPRSEKADPEFWRSAIKPIGEAVSGATLLLENDTWIETTLQPASEEEIEGTLRVMGGDDWENWIDTLINAESLAEGCKTIAFSYMGPDVTHPIYLDGTLGRAKIDLHQTSHALNLKLANFDGGAYAVVCKALVTKASVFIPGLSPYLLALYQVMKNKGTHEGCIEQMQRLFSDKLYGHSRIPLDSERLIRMDDWEMNPDTQVQVRERLQQMNASNFQQLGDYAGFKREFMQLNGFEFDQIDYSQSVDMHNFINKK
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH] 2, ENR 2.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: APT_LEPIN
Sequence: MSIVKSKIRTIPDYPKPGILFRDITSLLLDPEGLALTIGTFVNRYQGKGITKVAGIEARGFLTGAPLAFQLGVGFIPIRKKGKLPSETVSEEYDLEYGKDVIEVHKDSIQPGDKILLMDDLIATGGTMIAAVKLLKKLGAEIYEAGVIIDLPDLGGRKKLQEELKVPVFSICEFEGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_MALP2
Sequence: MAIKKSIRLECGECKEINYLTFKNAKKHPEKLELNKYCKRCRSAKPHKETKKK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: TRMD_MICLC
Sequence: MRFDVVTIFPEYLSVLDVSLLGRARREGLVDVHVHDLRDFTVDRHRTVDDTPYGGGAGMVMKPEPWALALEHVAAQGPAAPAPADPASAEPGDRPVLLVPTPSGERFTQRFARELAGREHVAIACGRYEGIDERVFGWAEELFEVRLVSLGDYVLNGGEVAALAMIEAVGRLVPGVVGNPASLVEESHEDGLLEYPVYTKPADWRGRAVPPVLLSGDHGKVAAWRRTQQEERTRERRPDLWAAFDSED
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_XANC8
Sequence: MRYALGVEYDGSEFQGWQQLGEHGGPSVQATLQAALSSVADAPIQVVCAGRTDAGVHGECQVVHFDSDARREPRGWMLGTTARLPPSVAVRWCVPAAEDFHARFSARARRYRYRLLNRQIRPALYRQTLSWERRPLDAQAMHTAAQALLGENDFGAFRSVQCQALHARRNLQAITVQRLGEVVEVQVQANAFLHHMVRNIVGSLILVGTGEQPIDWIATLLAGRDRTVAGPTAPPQGLVFIGPLYPAEWHLPAEVTQ
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: MNMG_YERPG
Sequence: MFYPDQFDVIIIGGGHAGTEAAMAAARMGRQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEIDALGGLMAKATDLAGIQFRILNASKGPAVRATRAQADRVLYRLAVRTALENQPNLMIFQQPVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLENYSGGRAGDPPSISLSQRLRELPLRVNRLKTGTPPRIDARTIDFSQLTPQLGDTPIPVFSFLGNAEQHPEQMACHITYTNEKTHEVIRNNLDRSPMYAGIIEGIGPRYCPSIEDKVMRFADRNSHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMKGLENARIIRPGYAIEYDFFDPRDLKPTLESKYIQGLFFAGQINGTTGYEEAAAQGLLAGLNAGRFANEEDGWSPRRDEAYLGVLVDDLSTLGTKEPYRMFTSRAEYRLMLREDNADLRLTETGRKLGLVDDIRWAHFSQKVEQIEKERQRLRDIWVHPHSENVSEINALLKAPLSKEANGEELLRRPEIDYRLLTSLTSFGPALTDPQSADQVEIQVKYEGYITRQQEEIEKQLRNENTLLPVDLDYQQVSGLSNEVIAKLNDHKPSSIGQASRISGITPAAISILLVWLKKQGLLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y978_GLOVI
Sequence: MTPEQQDLMDRAEQSLQAARILADEALFDVSVSRSYYAMFYCARASLLALNLSSKSHSGTISLFGQHLAAAGRLPIEIHRQLIDAERLRILGDYGGANSHCSQQDAQVLIAQSARFMQIAMEFLAQ
What are the official names of this protein?
UPF0332 protein glr0978.
What is the protein family that this protein belongs to?
Belongs to the UPF0332 family.
Protein: RS10_SALG2
Sequence: MQNQRIRIRLKAFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHKRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: DICB_DICDI
Sequence: MNKKIIILIYLIFIKSIVGQNPVWIGGSGCNLFTDSSCWSPSTSPLTTDIVTMGVDSTQTVVDGDITITTLINNNLTLGGVEMSSTISLEIIDTSLIVSGAFSMATNSRLSLSLSDSYANSLVSGSATRNAVNVLMNLQSMQTLMVGSSFTMTGNSVLDVNRSISTINGVFTMNDDTSLFMYSKQNGDSKFTVGNSVLNDASSLNFQGQSFIFFNQTNLPSGLVLNDQSKIVAIDADNVKISGVVTLNDQSSIQLTSSRLYLDSLVTATTSSILVNNSTLSILQSIPTTFSPASAVFKGSVFTIKSNCTIQSPITMIDSVYSFNQSHTLASQFTGSNVYMIMDAAILNAGNYYDCSGCSLSMRNSIANFDSYENQGDLILSSSKLNSNAPITSNTGSIFGYYGELNQALTVESGSLGVYNEKTRLFVNGNVIVESGAKIQFYLSSPLDFSWLNTSGSLDVQSGTIIEIYVYIEILNNGSMEVIKTSNGFVTPLSTDNVKLYTYDPDNDVITDFSTTGGCEYSISITNTSVLVHTDYACQQAIITLGTDGISKGSLAGISVSMVALACFVSLGVWWKTSKKNDQRNDSQVLTNFSQNKSDDIDVERKL
What is the function of this protein?
Component of a complex that acts as a quorum sensing protein regulating discoidin gene expression during growth and development.  Its function in the complex is unclear as it has no ability to induce discoidin during growth and development by itself.
What are the official names of this protein?
Discoidin-inducing complex subunit B.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Secreted.
Protein: CWC21_CANGA
Sequence: MGRGVGLQSAKGSSTSGYVQRSLAHDNRDDKTGIVRLKNKNYELRKITKRSQKVDKPANESKDNGLKKVLVEHDKRREIEVQVSELRDSLEDKQDRNPDEWPDKRIDEECEKLRSTLLADLQEKEKYQKAYTPRSKRSSESSK
What is the function of this protein?
Involved in pre-mRNA splicing.  May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome.  May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CWC21.
What is the protein family that this protein belongs to?
Belongs to the CWC21 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL30_BURCH
Sequence: MSEKTVKVQLVKSLIGTRESHRATVRGLGLRRLNSVSELQDTPAVRGMINKVSYLVKVIA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: TRUB_BACAH
Sequence: MEGVVLLHKPKGMTSHDCVFKLRKILREKRIGHTGTLDPDVTGVLPICVGRATKIAQFLTSETKTYEGEVTLGFSTTTEDASGEVVETKHVDRVITRKEVEGALAALTGTIEQMPPMFSAVKVNGKKLYEYARAGQEVERPVRTITIHEFVLLDDREVFEGETISFRFRVTCSKGTYVRTLAVMIGEKLGFPSHMSHLVRTASGEFLLEDCISFEEIEENVQNGTVESIFISIDEALSKFPKMVVDEKQAEKIKNGMFLKNELQITAPFITVFDKNDRCLAIYEHHPKHPGMLKPMKVLVNNQELKL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: NFIC_MOUSE
Sequence: MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKAEVKQKWASRLLAKLRKDIRPECREDFVLAVTGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAACAHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSSSPRTGVGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASAGMRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPNSPTSSSRNWTEDIEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPTSALHFPATPILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPATQQPGPPALRPTRPLQTVPLWD
What is the function of this protein?
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2.  These proteins are individually capable of activating transcription and replication.
What are the official names of this protein?
Nuclear factor 1 C-type, NF1-C, Nuclear factor 1/C, CCAAT-box-binding transcription factor, CTF, Nuclear factor I/C, NF-I/C, NFI-C, TGGCA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the CTF/NF-I family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDAD_METKA
Sequence: MGVPKKYALVSGTGEADTSLAAFDAALIDAGIGDCNLVELSSILPPNAEEDDLPEFPPGSIVPAVVAKAVGRGLVSSCICVGRLESGLGIVSERAATDSVETVRRLAKRDVEEMARLRGEKLVEVRTVTASTEPEDAEWAAAVAAVVFWG
What are the official names of this protein?
Pyruvoyl-dependent arginine decarboxylase, PvlArgDC.
What is the protein family that this protein belongs to?
Belongs to the PdaD family.
Protein: AVT6D_ARATH
Sequence: MSPAIKAPLLPNQEPSSSSSENHGSFAGAVFNISTSIVGAGIMAIPAAFKVLGVIPSLSIIVIIAWLSNVSAGFLMKSSLAGESTTYAGVMKESFGKSGAVAVTVVTMVVTFGSMIIFSIIIGDVISGNEKDGIIHLGLLQEWFGSHWWNTRFFGLLFIFVFLFLPLVLCRRVERLAFSSAISFLLALLFVVISSVLAIIALVQGKTKPPRLFPELNDGGLSFFSLFTASPVIVTAFTFHFNVHPVAFELKDPLNVLSATRISVILCATIYSATGLFCYLLFGDSTMTDVLMNFDQSTSSSVGSLLNDIVRLSYAIHLMLVFPLLNFSLRANLDELLFPMKLSLVEDNKRFFALTFPLLISCFLGAIAIPDIWYFFQFLGSTSTVSIAFIFPAAIVLRNVNGFSTLREKIVASVMLVLAVATSIIAISTNIYTFTATEET
What are the official names of this protein?
Amino acid transporter AVT6D, AtAvt6D.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.6) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MUTL_HALOH
Sequence: MPEIKRLPESVANQISAGEVVERPASVVKELVENSLDAGSNKILIEIENGGKDLIRVKDNGHGIPSDEIEIAFDRYATSKITDINDLYSLKSLGFRGEALASIASVSILDIISRTKSQTKAIKMRLKGGKVISKEPCGASVGTDIIVKDLFFNTPARYKYLKTTRNEFKHISNIITREALAYPGVNFTLIHNGRIVLKTPGTGKTLDCIYAIYGKEMAQSLVKIDYEDRYIKVSGYISRPDYYRYNRSYEIFFVNKRAVHNSILNRGVEEAYQGLLPPGAYPVVFLNLKLNPILVDVNVHPTKKEVKFSRDKVIKEVIQNGINIELSKLDKSPRLKRNINPLNRDDKTKDKSEYQKIKLPEDKEQITNKSSDAGILKNQNPLDSQDSILLPSKKNGFYSKKNSQVSQNKFMDINNKLEKTEINDNYKKDKHYKTDSINIKDNSIKENKNKMDIPIKRVLGQIKNTYIIAEGRDGLYIIDQHNAHERILYQSFIEKYNNSEIVSQPLVVPVNIETTAPEAEVLKSYLPQLEKMGFKLEVFGINSFIVREVPSLIKKRSNKRVVREVIDKLLEHDKAMKPSELINEIISYMSCRGAIKAGEYLDKKEAEQIIEGLFKTDNPYRCPHGRPIIIHITEDDINKGMGRK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: COBT_CLOPE
Sequence: MLNEVLKGIEGLDNDMIVKAKNRVDSLAKPLGSLGKLEDIAIRLSGITGNMFNNIDKKCVIIMSSDNGVEEEGVASAPQCVTLLQTKNFIKGTTGVATLAKANGTDLMVFDVGINSDEVVEGVINRKISKGTKNIYKEPAMTYEEAKKSLEIGIEAVKIAKEKGYKILGVGEMGIGNTTTSAAVLKALIGCETSQVVGKGGGINNDSFEKKKRIVEEVVKKHNINFDDSIDIISKVGGYDIGAMTGVFLGAAFYRIPVVIDGFISVVTALLANRLNPLVKEFCFTSHKSQEIGYELAIKELGLDPMLDLNMRLGEGSGCPIAFSVIDFATAMMNNMATFEEGNIDNSYLEDVKDEECYIVL
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RL15_CLOBB
Sequence: MKLHELQPAAGSRKAPKRVGRGTGSGLGRNAGKGEKGQNARSGGGVRPGFEGGQMPLYRRLPKRGFTNIFAKRYVSINVDRLNIFENGTEITPEVLLERRVVSKVLDGVKILGNGNLEKSLIVKGCKFSKSAIEKIEAAGGKVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: COXX_CUTAK
Sequence: MPFSISKDTVSNQTTHVATAPASQRPDPVETKVEQEQGRPRLSSRDVVHAYVALTKPRIIELLLVTTLPVMFLASHGVPKLGLVIATMVGGLFAAASANVFNCVIDVDIDQKMRRTRRRPLPRHQVPRRSALIYGIILWIIATIILGFGANWLSAALALIANLFYVFVYSMLLKRRTWQNTIWGGIAGCFPPLIGWTAVTGSVGWEPLVLFFIVFWWTPPHTWALSFRYREDYEAAGVPMLPVVRDAPEVAIQILIYTVMTVAISLVLWPVAHMGWIYVVVAVVSGAVFIVEAAQLLRRANAGLRDALLKPMGLFHWSNTYLSLLFLAIAVDPLIHL
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECA_ECOLI
Sequence: MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSTPDFSVDDSEGVAETNEDF
What is the function of this protein?
Mutations in this gene were selected in directed evolution experiments for resistance to intense ionizing radiation (3000 Gy).
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2114_RICFE
Sequence: MLLCKIKGYTERQKLNQKLMRAAATGDIEAVQKLVLRGADIYCRDHQGDTALSLAAGSGYLDILDI
What are the official names of this protein?
Putative ankyrin repeat protein RF_pd14.
Protein: CP21A_PIG
Sequence: MVLVWLLLLLTLLAGARLLWGQWKLRNLHLPPLVPGFLHLLQPNLPIYLLGLTQRLGPIYRLRLGLQDVVVLNSKRTIEEALVRKWVDFAGRPQIPSYKLASQHCPDISLGDYSLFWKAHKKLTRSALLLGVRSSMEPRVEQLTQEFCERMRAQAGTPVTIQKEFSVLTCSIICCLTFGDKEDTLVHALHDCVQDLMKTWEHWSIQILDMVPFLRFFPSPGLRRLKQAIENRDHLVEKQLRRHKESMVAGQWRDMLDYMLQEAGRQRVEEGQGQLLEGHVHMSVVDLFIGGTETTANTLSWAVVYLLHHPEIQWRLQEELDRELGPGAAGSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRATRPSSIFGYDIPEGTVVIPNLQGAHLDETVWEQPHEFRPDRFLAPGANPSALAFGCGARVCLGEPLARLELFVVLVQLLQAFTLLPPEGALPSLQPHPHSGINLKVQPFQVRLQPRGGRGEGPGPR
What is the function of this protein?
A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis.  Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Steroid 21-hydroxylase, 21-OHase, Cytochrome P-450c21, Cytochrome P450 21, Cytochrome P450 XXI, Cytochrome P450-C21.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: COX2_RHEAM
Sequence: AICSLVLYLLSLMLMEKLSSNTVDAQEVELIWTILPAIVLILLALPSLQILYMMDEIDEPDLTLKAIGHQWYWSYEYTDFKDLAFDSYMIPTTELPSGHFRLLEVDHRVVVPMESPIRVIVTAGDVLHSWAVPTLGVKTDAIPGRLNQTSFITTRPGIFYGQCSEICGANHSYMPIVVESTPLAHFESWSSLLSSSSSL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RAB8A_DICDI
Sequence: MTSPATNKSAAYDYLIKLLLIGDSGVGKSCLLLRFSEDSFTPSFITTIGIDFKIRTIELEGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDEKSFGNIRNWIRNIEQHATDSVNKMLIGNKCDMAEKKVVDSSRGKSLADEYGIKFLETSAKNSINVEEAFISLAKDIKKRMIDTPNEQPQVVQPGTNLGANNNKKKACC
What is the function of this protein?
Protein transport.  Probably involved in vesicular traffic (By similarity).
What are the official names of this protein?
Ras-related protein Rab-8A, GTP-binding protein SAS1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: CBX5_HUMAN
Sequence: MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPEDAENKEKETAKS
What is the function of this protein?
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression.  In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph).  Can interact with lamin-B receptor (LBR).  This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane.  Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
What are the official names of this protein?
Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha.
Protein: SLN12_HUMAN
Sequence: MNISVDLETNYAELVLDVGRVTLGENSRKKMKDCKLRKKQNESVSRAMCALLNSGGGVIKAEIENEDYSYTKDGIGLDLENSFSNILLFVPEYLDFMQNGNYFLIFVKSWSLNTSGLRITTLSSNLYKRDITSAKVMNATAALEFLKDMKKTRGRLYLRPELLAKRPCVDIQEENNMKALAGVFFDRTELDRKEKLTFTESTHVEIKNFSTEKLLQRIKEILPQYVSAFANTDGGYLFIGLNEDKEIIGFKAEMSDLDDLEREIEKSIRKMPVHHFCMEKKKINYSCKFLGVYDKGSLCGYVCALRVERFCCAVFAKEPDSWHVKDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINTSLPAPHSWPLLEWQRQRHHCPGLSGRITYTPENLCRKLFLQHEGLKQLICEEMDSVRKGSLIFSRSWSVDLGLQENHKVLCDALLISQDSPPVLYTFHMVQDEEFKGYSTQTALTLKQKLAKIGGYTKKVCVMTKIFYLSPEGMTSCQYDLRSQVIYPESYYFTRRKYLLKALFKALKRLKSLRDQFSFAENLYQIIGIDCFQKNDKKMFKSCRRLT
What is the function of this protein?
Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway.  E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity.  This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:35104454, PubMed:34272366, PubMed:34707099).  May play a role in cell differentiation (PubMed:30045019).
What are the official names of this protein?
Ribonuclease SLFN12, Schlafen family member 12.
What is the protein family that this protein belongs to?
Belongs to the Schlafen family. Subgroup II subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.