PharMolix/UniProtQA huggingface dataset:
Protein: OPAC_NEIGO
Sequence: ASEDGGRGPYVQADLAYAYEHITHDYPKPTDPSKGKISTVSDYFRNIRTHSIHPRVSVGYDFGGWRIAADYARYRKWSDNKYSVSIKNMRVHKHNSNRKNLKTENQENGSFHAVSSLGLSAIYDFQINDKFKPYIGARVAYGHVRHSIDSTKKITGLLTTSTPGIMSGVYKVLRTPGAHRESDSIRRVGLGVIAGVGFDITPKLTLDAGYRYHNWGRLENTRFKTHEASLGVRYRF
What is the function of this protein?
Implicated in a number of adherence functions.  OPA proteins are implicated in pathogenesis and are subject to phase variation.
What are the official names of this protein?
Opacity protein opA50, V0, opA30.
What is the protein family that this protein belongs to?
Belongs to the opacity porin family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: RN175_HUMAN
Sequence: MAAGTAARKAAPVLEAPPQQEQLSHTKLSAEDTWNLQQERMYKMHRGHDSMHVEMILIFLCVLVIAQIVLVQWRQRHGRSYNLVTLLQMWVVPLYFTIKLYWWRFLSMWGMFSVITSYILFRATRKPLSGRTPRLVYKWFLLIYKLSYAFGVVGYLAIMFTMCGFNLFFKIKARDSMDFGIVSLFYGLYYGVMGRDFAEICSDYMASTIGFYSVSRLPTRSLSDNICAVCGQKIIVELDEEGLIENTYQLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMISNPWERTHFLYGQILDWLRYLVAWQPVVIGIVQGIIYSLGLE
What are the official names of this protein?
RING finger protein 175.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYR_MYCMS
Sequence: MSTTIIEMFYNDLKNICQKLNITKEPIIEINKNNTPGLLSSSICLISSKQVNKKPLELAEIFKQELLLTNSYLNIDIAAPGFLNVLVKPEILSNVISNVLSLKSKYGNLEKQNKTINIEYVSANPTGYLHVGHARNAVIGSVLVNLFKKAGYNVQTEYYVNDAGNQINVLAVTVFVHYLQALNIDAKKPENCYAGDMYDDLAKIIINKYNYQFKDIKYTDNKILDYNVHSLFKQISIDYFLKVIKQQLADFNVKIKHWSSEQEVYDTHQIEKVLKLYESKDALYYKDDALFLKTTQFGDDKDRVLVKSDKTYTYILPDLATHNLRIKRTKADKLINVWGGDHHGYIKRMQAGLALLGNDPDILEIQMVQMVRLIKDGSEYKMSKRKGTAVWLVDILELVGVDALRYMLASKSSNSHMDLDLDLITLKNSSNPVYYAQYATARCHSILNQARTKKITPLVKETNLLNNPKEIELLLVLDNFKEVIKNSANNRSTQQICDYIQNICKIFHSYYAEIKIIDENNLQLTKLRLGFIKAVLQVLENAFFIIGIQPVLEM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MD27B_XENLA
Sequence: MVDALNVGVNLEAFSQAIHCIQALRSSVTRVFDCLKDGMKNKESQEARERTFVSEFQDNLHSVNGDLNELERLSNLVGKPSENLPLHNSGLLSLDPVHDKTPLYSQLLQAYKWSNKLQFHAGLASGLLNQQSLKRSAIQMGVSTKRRPKVQPTTLALPPQYIDDVISRIDRMFPEMTIQLSRPNGSSAILLVILGKVLKVIVVMRSLFIDRTIVKGYTENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLESFHDSCRQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 27-B, Cofactor required for Sp1 transcriptional activation subunit 8-B, CRSP complex subunit 8-B, Mediator complex subunit 27-B.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 27 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACDH_MYCTO
Sequence: MPSKAKVAIVGSGNISTDLLYKLLRSEWLEPRWMVGIDPESDGLARAAKLGLETTHEGVDWLLAQPDKPDLVFEATSAYVHRDAAPKYAEAGIRAIDLTPAAVGPAVIPPANLREHLDAPNVNMITCGGQATIPIVYAVSRIVEVPYAEIVASVASVSAGPGTRANIDEFTKTTARGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPTDADREAIAASIHDVVKEVQTYVPGYRLLNEPQFDEPSINSGGQALVTTFVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKETLVVGGAR
What is the function of this protein?
Involved in cholesterol degradation.  Catalyzes the conversion of propanal to propanoyl-CoA, using NAD(+) and coenzyme A.
What are the official names of this protein?
Propanal dehydrogenase (CoA-propanoylating), Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: GCH4_NEIG1
Sequence: MNAIADVQSSRDLRNLPINQVGIKDLRFPITLKTAEGTQSTVARLTMTVYLPAEQKGTHMSRFVALMEQHTEVLDFAQLHRLTAEMVALLDSRAGKISVSFPFFRKKTAPVSGIRSLLDYDVSLTGEMKDGAYGHSMKVMIPVTSLCPCSKEISQYGAHNQRSHVTVSLTSDAEVGIEEVIDYVETQASCQLYGLLKRPDEKYVTEKAYENPKFVEDMVRDVATSLIADKRIKSFVVESENFESIHNHSAYAYIAYP
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2, GTP cyclohydrolase 1B.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: IRF8_MOUSE
Sequence: MCDRNGGRRLRQWLIEQIDSSMYPGLIWENDEKTMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGVAPAGCMSEVPEMECGRSEIEELIKEPSVDEYMGMTKRSPSPPEACRSQILPDWWVQQPSAGLPLVTGYAAYDTHHSAFSQMVISFYYGGKLVGQATTTCLEGCRLSLSQPGLPKLYGPDGLEPVCFPTADTIPSERQRQVTRKLFGHLERGVLLHSNRKGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTNQFIRELQQFYATQSRLPDSRVVLCFGEEFPDTVPLRSKLILVQVEQLYARQLVEEAGKSCGAGSLMPALEEPQPDQAFRMFPDICTSHQRPFFRENQQITV
What is the function of this protein?
Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:2111015, PubMed:12393690).  Can both act as a transcriptional activator or repressor (PubMed:2111015).  Plays a negative regulatory role in cells of the immune system (PubMed:2111015).  Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (PubMed:12393690, PubMed:22992524).  Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (PubMed:12461077, PubMed:12393690, PubMed:12538667, PubMed:23382217).  Positively regulates macroautophagy in dendritic cells (By similarity).
What are the official names of this protein?
Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, ICSBP.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction.
Protein: RECF_TRIV2
Sequence: MYLKTLHLRHFRNYYDQKVEFTAAKTILVGNNAQGKSNLLEAVELLATLRSHRMARDRDLVQEEEPLAQINATLERDTGVSDLSLILRRNGRRTVALNGESLRRQMDFLGVLNAVQFSSLDLELVRGSPEVRRNWLDTLLIQLEPVYAHILQQYNQVLRQRNAYLKKLQDSALTTQDSALAIWDAQLVTTGTKVIRRRDRALARLAPLATAWHTSISGSTEVLQISYTPNVQLMQNQPEQVQQAFLSQLQQRAVPEMYRGTTLVGPHRDEVELTINQTPARQYGSQGQQRTLVLALKLAELQLIEEVVKEPPLLLLDDVLAELDPSRQNQLLDTIQDRFQTLITTTHLSSFDAQWLNSSQILFVEQGKISTSNSIR
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_STRP8
Sequence: MDIREIQAALPHRYPMLLVDRVLEVSDDHIVAIKNVTINEPFFNGHFPHYPVMPGVLIMEALAQTAGVLELSKEENKGKLVFYAGMDKVKFKKQVVPGDQLVMTATFIKRRGTIAVVEARAEVDGKLAASGTLTFACGQ
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJJP_KLEAK
Sequence: MQADKSEQRAVTRLCIQCALYLLQHGAESALVEELSTRLGRALGMDSVESAISSNAIVLTTIKDGECLTSTRKNSDRGINMHVVTEVQHIVIMAEHKLLDYKDVEKRFSQIKPLRYPRWLLVLMVGLSCACFCKLNNGGWDGAVVTFFASTVAMYIRQLLTHRSMHPQINFCITAFVATTISGLMLRLPAFSETPTIAMAASVLLLVPGFPLINAVADMFKGHINTGLARWAIASLLTLATCIGVVMAMTMWGLRGWA
What is the function of this protein?
Involved in succinate export with YjjB.  Both proteins are required for export (PubMed:29395959).  Participates in succinate export, but also in the export of other dicarboxylates, such as fumarate and malate (PubMed:29395959).  Contributes to succinate production under both aerobic and anaerobic conditions, and increases fumarate and malate production during anaerobic succinate production (PubMed:29395959).
What are the official names of this protein?
Probable succinate transporter subunit YjjP.
What is the protein family that this protein belongs to?
Belongs to the ThrE exporter (TC 2.A.79) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENCB_ASPFU
Sequence: MDQYSNLFAFEDYLGAQARSIPDLPEVDVLSPRVVRVLGGNPGQMQLQGTNTYILGTGAERLLIDSGQGRARWEQLMASLAAEHKFRISTVLLTHWHLDHTGGVPHLFRIFPELRGANAIYKYHPDPSQQAIVDGQVFSVEGATVRAVFTPGHSTDHMCFLLQEEEAIFTGDTVLGHGTTGVEDLEEYMQSLRKIQSLGCRIGYPGHGAVIENMQQKVQQEIDRKQRRERQVLLALQNIQREKRTVGDANGAATQAELIEAIFGRLPADVADRFFAPYMKDILMKMARDKQVGFRFKGGQKHWFANVSQENPVCR
What is the function of this protein?
Atrochrysone carboxyl ACP thioesterase; part of the gene cluster that mediates the biosynthesis of endocrocin, a simple anthraquinone interesting for many biotechnological applications (PubMed:22492455, PubMed:23592999).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) encA (PubMed:22492455).  The atrochrysone carboxyl ACP thioesterase encB then breaks the thioester bond and releases the atrochrysone carboxylic acid from encA (PubMed:22492455).  The atrochrysone carboxylic acid is then converted to endocrocin anthrone which is further oxidized into endocrocin by the anthrone oxygenase encC (PubMed:22492455).  The exact function of encD has not been identified yet, but it negatively regulates endocrocin production, likely through the modification of endocrocin itself (PubMed:22492455).
What are the official names of this protein?
Atrochrysone carboxyl ACP thioesterase, ACTE, Endocrocin synthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: FOLD_PSYA2
Sequence: MSIASIASTAQGSATILDGKALAKQIEQQLSTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACQRVGMDSIRVEMPSATTTAELMAKIDELNNNPDVHGILLQHPVPAHIDERACFEQIDLAKDVDGVTCLGFGRMAMQQSAYGSCTPQGIMHLLEHHNIELAGLEAVVVGRSAILGKPMAMMLLNANCTVTICHSRTQDLESHIKRADIVVGAVGVPELIKANWIKAGAVVIDAGFHPTDNGGVGDIELQGVENIASAYTPVPGGVGPMTINTLIRQTVDAAEKSAGL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CHSB_SOLTU
Sequence: MVTVEEYRKAQRAEGPATILAIGTSTPSNCVDQSTYPDYYFRITNSEHKTELKEKFKRMCDKSMIKKRYMHLTEEILKENPNMCAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGCDYQLAKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAIIMGSDPIIGVERPLFELVSAAQTLVPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLLEAFQPLGISDWNSLFWIAHPGGPAILDQVELKLGLKQEKLRATREVLSNYGNMSSACVLFILDEMRKASTKEGLGTTGEGLEWGVLFGFGPGLTVETVVLHSVAT
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 1B, Naringenin-chalcone synthase 1B.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: YL225_YEAST
Sequence: MAVAIKKEKTKFAPVKEVLSEKDHANYTKFQDTSKLEWFCRTSNHKKFKSHSLLKAVRNPTETRIETQTLYFTDLTNGKCGLIQLLYSSVMGGIYKGFQLNFKIFKASSEENSEEDIDIWESFKIDNIKDFDTLKVESDNVTFHFVPLENSSSSGFAQLLIKIDIPKGSTSCLLKDLKVDITVNLQEGFIINPDGSNYYLDKSISLEELAKRDSSSTSRKMIRHVFVPRGFCNGTISYKKNDKPVKLDLKDTPMLYLDAVQGLIPNKAASKWNFLCFNGEKRSMMCIEFTTTKEYGSTTVTIWAVSDKDKILEVGSSVNDHAVKFPSTKEDKQNGWKYPTSISFPRGFEESNLRLVNRYDIMSELPAFIRSIAENLANMKPFIYQFCQKSKFDDDEGVSIIESTFIN
What are the official names of this protein?
Uncharacterized SVF1-like protein YLR225C.
What is the protein family that this protein belongs to?
Belongs to the SVF1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P69_MESHY
Sequence: MIKENLFFEWVDKNNKKLKLKWKILILLLSLLLFIFSFYSLFQPINYGSTRIFTKNLKELFTFSNYSKKYPSWTLWQLSWYYMFLTIRYCALGTTLGFIFAFFTSFVSSNFQKYKFIRYIINIIIIFFKAFPISLFVYFFSIGFDKELAATLILFWFSWLWMHKYFLDFLNNLDKTNYKIMHMKTNENFASFRKTLFPYIVNKYFMFFVYSLESNIRWTTIINAAGVIGIGLLLNDARDFSLGWSVVGIPLLVILVTIIFFEFLTLFLNKVILNIKNINYQNTSFLWIKLNFRRIFKWFFVLFFVGLNIYSIIKISSFTLYPNYIKNFWNHFFSFQNEVFSHNKENNPFYWILILIYQCIVSITIIAIISLVFSILGNEKLNNVTQWIPLRFLNTLFRIIPTIIFIYLFSIFWIGTNIFLLVAVITALRKSTSLVKQLNESINSINWEIYKTLEIQGKSKFQRIIKFVFPSIKKDYLSFLLFYFENQVQTLILLGSVGGSLLGSKISIVGQAGERTENILELMTYSWISWVFIAIIQLLQFYFNLIVQNKKISQLYLIKNLNTYFTKIKVIFKNKFSSDQ
What is the function of this protein?
Probably part of a high-affinity transport system.
What are the official names of this protein?
ABC transport system permease protein p69.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PROA_STRU0
Sequence: MTIIEELGKKAKQASYDLLGLSTIEKNQMLTQLAKDLIEKSDFIIDENQKDLQKAEENGISEVMVDRLKLTAERIKGISEGVLQVAELEDPIGQVIKGYTNLDGLKIVQKRVPLGVIAMIFESRPNVSVDAFSLAFKTNNAIILRGGRDALHSNMALVQVIRETLIRLGHNPDAVQLLEDPSHDLAEALMSATEYVDVLIPRGGAKLIQTVKEKAKVPVIETGVGNVHIYVDATADLEMAKSIVINAKTQRPSVCNAAESLIIHEEVAENFIPLLEDAIEAVHKVEFRVDDKGYSLFKHAVKATENDYATEFLDYILSVKIVSSLDEAISWINRYTSHHSEAIVTRDIQAAERFQEEIDAAAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMGLEALTSSKYYINGNGQIRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNB_ECOLI
Sequence: MAEGKAMSEFLPFSRPAMGVEELAAVKEVLESGWITTGPKNQALEQAFCQLTGNQHAIAVSSATAGMHITLMALKIGKGDEVITPSLTWVSTLNMISLLGATPVMVDVDRDTLMVTPEAIESAITPRTKAIIPVHYAGAPADIDAIRAIGERYGIAVIEDAAHAVGTYYKGRHIGAKGTAIFSFHAIKNITCAEGGLIVTDNENLARQLRMLKFHGLGVDAYDRQTWGRAPQAEVLTPGYKYNLTDINAAIALTQLVKLEHLNTRRREIAQQYQQALAALPFQPLSLPAWPHVHAWHLFIIRVDEQRCGISRDALMEALKERGIGTGLHFRAAHTQKYYRERFPTLSLPNTEWNSERICSLPLFPDMTTADADHVITALQQLAGQ
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, Polymyxin resistance protein PmrH, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: CLPX_CAUSK
Sequence: MTKAASGDTKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREEHKIAFVKSKDGVPTPREICEVLDDYVIGQNHAKKVLAVAVHNHYKRLNHASKNNDVELAKSNILLVGPTGTGKTLLAQTLARIIDVPFTMADATTLTEAGYVGEDVENIVLKLLQAADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLERIISARGQGKSIGFGAKVADPEERRTGEILRGVEPDDLQRFGLIPEFIGRLPVIATLEDLDEAALVKILTEPKNAFVKQYQRLFEMENIGLTFTEDALHGVAKKAILRKTGARGLRSIMEGILLETMFELPNYEGVEEVVVNAEVVEGRAQPLLIYAEKKGGAASA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: PROB_ECOL5
Sequence: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHVGQMLLTRADMEDRERFLNARDTLRALLDNNIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQKGLYTADPRSNPQAELIKDVYGIDDALRAIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIAAGSKPGVIGDVMEGISVGTLFHAQATPLENRKRWIFGAPPAGEITVDEGATAAILERGSSLLPKGIKSVTGNFSRGEVIRICNLEGRDIAHGVSRYNSDALRRIAGHHSQEIDAILGYEYGPVAVHRDDMITR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EST3_DEBHA
Sequence: MNVNIKYPLVLHDNWLLESITGQINKNVKYTNSLIKKDFISPSSISKTPILRILRFLKTTKSSDLTAILSDSTHTVIAIFPFDPAIINFEIRYKHRITYHTPNSLILIKQANLRFVNNVELTTEWGITIEDEIDVAVLEVLDLEIFQRDQIMLGVNIENNLQLIYYDKSYLNLCGKSRQRDSLGEKEIKEVISQSYDDVVSI
What is the function of this protein?
Component of the telomerase complex involved in telomere replication.  Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).
What are the official names of this protein?
Telomere replication protein EST3.
What is the protein family that this protein belongs to?
Belongs to the EST3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: VPU_SIVTN
Sequence: MIKIVVGSVSTNVIGILCILLILIGGGLLIGIGIRRELERERQHQRVLERLARRLSIDSGVEEDEEFNWNNFDPHNYNPRDWI
What is the function of this protein?
Enhances virion budding, by targeting human CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its receptor human CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to interfere with the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo (By similarity).
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: NPY_MOUSE
Sequence: MLGNKRMGLCGLTLALSLLVCLGILAEGYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMKESTENAPRTRLEDPSMW
What is the function of this protein?
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
What are the official names of this protein?
Pro-neuropeptide Y.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
Protein: RUVA_ECO24
Sequence: MIGRLRGIIIEKQPPLVLIEVGGVGYEVHMPMTCFYELPEAGQEAIVFTHFVVREDAQLLYGFNNKQERTLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGALVKLPGIGKKTAERLIVEMKDRFKGLHGDLFTPAADLVLTSPASPATDDAEQEAVAALVALGYKPQEASRMVSKIARPDASSETLIREALRAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: HSLO_SYNE7
Sequence: MADQLIRATAAGGGIRAVGVITTDLTAEAQRKHGLSFVATTALGRSMAAGLLLASSMKKEGSRVNLRIRSAGPLGGLMVDAGLDGTVRGYVEHPAIEIEPNTQGLPDVGRAIGPGYLHVMRDVGYGQPYTSTVELVNGEIGDDVAYYLASSEQTPSAILLGVYLDRQGVEAAGGLLIQVLPQAARDPELVSLLESRISHLKGFTQLLRSGKDLPEILEDLLGDLDLTILAEPRSLRFFCPCTHQRMLGALKIFGAPELRDMIAKDQGAEATCEFCSEVYQASIEELEELISDLETAA
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMN6_SALPA
Sequence: MSQSGSALRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVADVKRILDIGTGSGLLALMLAQRTDDNVPIDAVELDAGAAMQAQENVAHSPWPHRITVHTDDIQRWAPRQTVRFDLIISNPPYYEPGVECATPQREQARYTATLDHQTLLAIAADCITEDGFFCVVLPEQIGNAFTQQALNMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGSDQHYSESYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMUV_HAHCH
Sequence: MIHAFAVSVIRHERTLLEQINFRLNPGELVVTLGPNGAGKSTLLKTLAGDLPPSHGHVLLDDEPISQFSLSQLSRRRAVLSQSVHLDFPFSAMEVVLMGAQRTLSGGDPFRLSQQALEEVDAGHLAQRNYQDLSGGERQRVQIARALTQLWTGVGAGPQYLMLDEPTSALDLKHQSALLKLARKLAGKGVGVFCVLHDLHLAAQYADRILLMNHGRIVAEGAPETLITTANVREVYQVDSRILPHPVTQRPMVMID
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.