PharMolix/UniProtQA huggingface dataset:
Protein: PDX13_ARATH
Sequence: MEGTGVVAVYGNGAITEAKKSPFSVKVGLAQMLRGGVIMDVVNAEQARIAEEAGACAVMALERVPADIRAQGGVARMSDPQMIKEIKQAVTIPVMAKARIGHFVEAQILEAIGIDYIDESEVLTLADEDHHINKHNFRIPFVCGCRNLGEALRRIREGAAMIRTKGEAGTGNIIEAVRHVRSVNGDIRVLRNMDDDEVFTFAKKLAAPYDLVMQTKQLGRLPVVQFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDPARRARAIVQAVTHYSDPEMLVEVSCGLGEAMVGINLNDEKVERFANRSE
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by PDX2.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.  Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PDX1.3, AtPDX1.3, AtPDX1;1, PLP synthase subunit PDX1.3.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Membrane.
Protein: Y1413_STAEQ
Sequence: MAKKVAIILADEFEDIELTSPKEALENAGFETEVIGDTANHEVVGKHGEKVTVDVSIADAKPENYDALLIPGGFSPDHLRGDEEGRYGTFAKYFTKNDVPTFAICHGPLVLVDTDDLKGRTITGVINVRKDLSNAGANVVDESVVVDNNIVTSRVPDDLDDFNREIVKKLEA
What are the official names of this protein?
Uncharacterized protein SERP1413.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family.
Protein: HAS1_EMENI
Sequence: MPAAVDTAKTISKKRKRKHGGSAREATDNGVATSPAENGVEGKATETTTELTKDKDVELAKKVVKEEAQKKRKVSHSPSDEEESESEDEEKKEEDEKDNVKEDSGKANVPDLPSVDAVSLPQPDGGPKKFTELGLSEKTLQGIKEMGFETMTEIQQRTIPPLLAGRDVLGAAKTGSGKTLAFLIPAIEMLSALRFKPRNGTGVIVVSPTRELALQIFGVARELLTAHSQTYGIVIGGANRRAEAEKLTKGVNLLIATPGRLLDHLQNTPGFVFKNLKTLVIDEADRILEVGFEDEMRQIIKILPNEDRQTMLFSATQTTKVEDLARISLRPGPLYINVDHRKEHSTVEGLEQGYVICEADKRFLLLFSFLKRNLKKKIIVFFSSCNCVKYHAELLNYIDLPVLDLHGKQKQQKRTNTFFEFCNAKQGVLICTDVAARGLDIPAVDWIIQFDPPDDTRDYIHRVGRTARGANGRGRSLMFLQPSEVGFLKYLKEARVPVVEFDFPAKKIVNVQSQLEKLISQNYYLNKSAKDGYRSYLQAYASHSLRSVFDVHKLDLVKVAKSFGFSTPPRIDIQLGSSLSRDKKQQQQGRRSYGSQPKGLKFKRKHEDD
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase has1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MTAB_BACSU
Sequence: MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVINTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDREKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFCIIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSELDTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYTMEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSKRTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEEENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLSS
What is the function of this protein?
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
What are the official names of this protein?
Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB, tRNA-t(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MtaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_ECOLI
Sequence: MSNRKYFGTDGIRGRVGDAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSALFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDAVEEAIEAEMEKEISCVDSAELGKASRIVDAAGRYIEFCKATFPNELSLSELKIVVDCANGATYHIAPNVLRELGANVIAIGCEPNGVNINAEVGATDVRALQARVLAEKADLGIAFDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMARNHMSLHDLCSGMKMFPQILVNVRYTAGSGDPLEHESVKAVTAEVEAALGNRGRVLLRKSGTEPLIRVMVEGEDEAQVTEFAHRIADAVKAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.  Can also catalyze the formation of glucose-6-P from glucose-1-P, although at a 1400-fold lower rate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: METN1_ALKCK
Sequence: MIEFKQVTKTFHSGNQTVTALDNVNLHVARGEIYGVIGFSGAGKSTLIRSANLLERPTSGEVLINGVNLATLKSRELQKAKRNIGMIFQHFNLLQSKTVFDNVATPLKLTRTPKADIRKRVTELLSFVGLSDKADNYPEQLSGGQKQRIGIARALATNPEVLLCDEATSALDPDTTSSILHLLKKINIEYNITILMITHEMSVIREICDKVAVMEKGRIIEEGSVLSIFSNPQHPTTEKFVRSIIPTGLPARVKEALQQKEPNRRIYEVTVTGDSSHSDLLRSLIQTFGIEVDILHATMNDIQGTSFGRIYFDLRAEPEILAEASNYLKSHPLQPKEVTGDARVAA
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MNME_SHEB5
Sequence: MTTDTIVAQATAPGRGGVGIIRISGDKASNVAMAVLGHLPKTRYADYCDFKSASGQVIDQGIALFFKGPNSFTGEDVLELQGHGGQIVLDMLIKRVMEVGGIRIAKPGEFSEQAFMNDKLDLTQAEAIADLIDATCEQAAKSALQSLQGEFSKEVHELVDQVTNLRLYVEAAIDFPDEEVDFLSDGKIANALYKIIDKLDLVQASAKQGSIIREGMKVVIAGRPNAGKSSLLNALAGKESAIVTEIAGTTRDVLREHIHLDGMPLHIIDTAGLRDTTDTVEQIGIERAWNEINSADRVLFMVDGTTTAAVDPHAIWPDFVDRLPSNLGVTVIRNKADLTGEDLMMTEEQGYSVYRISAKTGLGVEELKQHLKSLMGYQSNLEGGFIARRRHLEALELAAGHLQLGKEQLEVYLAGELLAEELRMCQLALSEITGRFTSDDLLGKIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_CAMPM
Sequence: MSRGALIVFEGLDKSGKTTQCMNIMESILANTIKYLNFPQRSTVTGKMIDDYLTRKKTYNDHIVNLLFCANRWEFASFIQEQLEQGITLIVDRYAFSGVAYAAAKGASMTLSKSYEFGLPKPDLVIFLESGSKEINKNVGEEIYEDVAFQQKVLQEYKKMIEEGDIHWQIISSEFEEDVKKELIKNIVIEAIHTVTGPVGQLWM
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RECR_MYCUA
Sequence: MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPPDIDRLTAVLAKVRDGVRFCAVCGNVSDDERCRICADPRRDGALVCVVEEPKDIQAVERTREYRGRYHVLGGAFDPLSGIGPEQLRIRELLTRIGDRVDGVDITEVIIATDPNTEGEATATYLVRMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALTGRRAMV
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: ENDO1_ARATH
Sequence: MASAFRSSTRLILVLGILILCSVSSVRSWSKEGHILTCRIAQNLLEAGPAHVVENLLPDYVKGDLSALCVWPDQIRHWYKYRWTSHLHYIDTPDQACSYEYSRDCHDQHGLKDMCVDGAIQNFTSQLQHYGEGTSDRRYNMTEALLFLSHFMGDIHQPMHVGFTSDEGGNTIDLRWYKHKSNLHHVWDREIILTALKENYDKNLDLLQEDLEKNITNGLWHDDLSSWTECNDLIACPHKYASESIKLACKWGYKGVKSGETLSEEYFNTRLPIVMKRIVQGGVRLAMILNRVFSDDHAIAGVAAT
What is the function of this protein?
Endonuclease that can use RNA, single-stranded and double-stranded DNA as substrates (PubMed:23620482).  Hydrolyzes single-stranded DNA and RNA without apparent specificity for bases during senescence.  Endonuclease that recognizes and cleaves all types of mismatches with high efficiency, including heteroduplex double-stranded DNA.  Maybe involved in programmed cell death (PCD) and senescence.
What are the official names of this protein?
Endonuclease 1, AtENDO1, Bifunctional nuclease I, AtBFN1, Deoxyribonuclease ENDO1, Single-stranded-nucleate endonuclease ENDO1.
What is the protein family that this protein belongs to?
Belongs to the nuclease type I family.
Protein: UBIB_MARN8
Sequence: MTRLQRLFRIAWVFCRYRLDTFLPLSELPTPLKIFFLLAPWHLFPQPKLSRGDRLRLALEELGPVFVKFGQILSTRRDLLPDDMAESLKQLQDRVPPFPSEQARGIIEKSLGAPVSELFAEFSPDPMASASVAQVHAATLPNGQKVVVKVLRPGIEKVIRQDLGLMYLMAGLLEKYWSEGKRLHPVEVVADYDSTIHDELDLQREAANASQLRRNFENSPLIYIPFIDWDYTRKSVLVMERIHGIPIADVPALEKAGVNMRVLAEKGVEIFFTQVFRDSFFHADMHPGNIFVDVSNPADPKYIAIDFGIVGTLAPDDQSYLARNLLAFFRRDYRQVAQLHIQSGWVPPETRVNEFEAAIRTVCEPIFERPLKDISFGHFLLRLFQTARRFNMEVQPQLVLLQKTLLNVEGLGRQLYPDLDLWSTAQPFLEDWMRKRIGPSGLIKSLQNHLPSWLEQSPEMPQLVHDALLQIRSSGPTEAQNRATLALMKEQQLRSERRWRRGFIALVLAGAALVGSQPHAGQWLADLPVWSWALLAGAAGVMLRGSR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL17_LEUMM
Sequence: MAYRKLGRTSSQRKAMLRDLTTDLLINGRITTTEARAKEVRKTTDKMITLGKRGDLNARRQAATFVRNEVADVIEDGDDVKVQSALQKLFDDVAPRFAERNGGYTRILKTVQRRGDAAQLVILELVD
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RPE_YEAST
Sequence: MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD
What is the function of this protein?
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate (By similarity).  Involved in the protective response to oxidative stress.
What are the official names of this protein?
Ribulose-phosphate 3-epimerase, Pentose-5-phosphate 3-epimerase, PPE, RPE.
What is the protein family that this protein belongs to?
Belongs to the ribulose-phosphate 3-epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCA2_ARATH
Sequence: MGTLGRAIYTVGNWIRGTGQALDRVGSLLQGSHRIEEHLSRHRTLMNVFDKSPLVDKDVFVAPSASVIGDVQIGKGSSIWYGCVLRGDVNNISVGSGTNIQDNTLVHVAKTNISGKVLPTLIGDNVTVGHSAVIHGCTVEDDAFVGMGATLLDGVVVEKHAMVAAGSLVKQNTRIPSGEVWGGNPAKFMRKLTDEEIVYISQSAKNYINLAQIHASENSKSFEQIEVERALRKKYARKDEDYDSMLGITRETPPELILPDNVLPGGKPVAKVPSTQYF
What is the function of this protein?
Enzyme involved in the catabolism of H(2)CO(3) but that does not mediates the reversible hydration of carbon dioxide (PubMed:19808034).  Mediates complex I assembly in mitochondria and respiration.  Binds HCO(3)-.  Required for male fertility during anther development and dehiscence to regulate the secondary thickenings of the endothecial cell wall, probably by modulating H(2)O(2)-dependent lignin polymerization.
What are the official names of this protein?
Gamma carbonic anhydrase 2, mitochondrial, AtCA2, GAMMA CA2, Transcription factor APFI.
What is the protein family that this protein belongs to?
Belongs to the gamma-class carbonic anhydrase family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Peripheral membrane protein; Matrix side. Note=Probably integral to the membrane.
Protein: YG4I_YEAST
Sequence: MPRDPLIGIVGKPSSGKSTTLNSLTDAGAAVGAFPFTTIEPNQATGYLQVECACSRFGKEDLCKPNYGWCSKGKRHIPIKLLDVAGLVPGAHSGRGLGNKFLDDLRHADALIHVVDVSGTTDAEGKNTRGYDPLNDIEWLQDEIRLWVEGNLKKRWGSIVRKHTATKSSIVDTLQAQFGGYGSHAPMIQKALDRLKGLPPLEKWDDEWITRVVKSFMMEKFPTVLALNKIDHPDADKNVSKIMLKYPDTKAVLTSAVTEVFLRKLKKQGFILYEEGTEFVDTFEDEPDKLKPLDDKILNRIENIRDLVLYRFGSTGVVQVLQAATDILGLIPVYTVKNIQTFTGGNGTNVFRDCFLVKRGTPVGKVARYIMGGEVTIASIETVGGVRVSEESLVEPGKNDILGFKIAPRSA
What are the official names of this protein?
Uncharacterized GTP-binding protein YGR210C.
Protein: ROP1L_BOVIN
Sequence: MPLPDTMFCAQQIHIPPELTDILKQFTKAAIRTQPADVLQWSAGYFSALSRGDPLPVKDRIEMPMATQKTDTGLTQGLLKVLHKQCSHKEYVDLADLEQKWKNLCLPVEKFRALLQLDPCEDKIEWIKFLALGCSMLGGSLNTAMKHLCEILTTDPEGGPARIPFGTFSYVYRYLSGLDSDIPESDTEAYLSSLKENAAARKNGMIGLSDFFVLKRKI
What is the function of this protein?
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.  Important for male fertility.  With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
What are the official names of this protein?
Ropporin-1-like protein.
What is the protein family that this protein belongs to?
Belongs to the ropporin family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Cell projection, cilium.
Protein: DDH_HALMT
Sequence: MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV
What is the function of this protein?
Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids.  Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH.  Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.
What are the official names of this protein?
D-2-hydroxyacid dehydrogenase, D2-HDH, D-specific 2-hydroxyacid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: SELO_RHIME
Sequence: MTAFRFDNSYARLPANFYARVQPTPVAEPWLIKLNRPLAGELGLDAEALERDGAAIFSGNLVPEGAEPLAMAYAGHQFGTFVPQLGDGRAILLGEVTDAGGRRRDIQLKGAGQTPYSRRGDGRAALGPVLREYIVSEAMHALGVPTTRALAATATGQPVYREQILPGAVFTRVAASHIRVGTFQFFAARGDMESIRTLADYVIGRHYPELKTDEKPYLALLKAVAARQAALIARWLHVGFIHGVMNTDNMTISGETIDFGPCAFMDDYDPKTVFSSIDQFGRYAYANQPAIGQWNLARLAETLVTLFDPVADTAVNLANDALGEYGTIFQKHWLDGMRRKIGLLTDEDEDLDLVQSLLTLMQNGKADFTLTFRRLAASAENATADTELASLFEEPQALSPWLEHWRRRLEREPQPATERAAAMRSVNPAFIPRNHRVEQAIAAATEDADFSLFEALLDVTSRPYEDQPGHAAYAAPPEPGEEVLQTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: SPEE_RUEST
Sequence: MTKEVWNTERLHDHFAQSLRVSEMYYDSKTEHQRLKVFQNGTFGRVLTLDDVVQTTEGDNFIYHEMLTHVPILAHGAAKRVLIIGGGDGGIAREVLKHASVEHVTMVEIDAGVVDFSKEYLPMLSQGAFDDARLNLVINDGAVFMKETEDKFDVIIVDSTDPIGPGEVLFTDTFYGHAARALTEDGIIVTQNGVPFMQGDELTNTMRAFQALFQDATCYLATIPTYVGGPMALGWGSHSTKARSVDLTTLEARFAAAGLSPDYYTPEVHKAAFALPGYVKKLFP
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTAA_BACCN
Sequence: MQRFIKWLAVITSLDLLGVLLGGALVTKTDSGQGCGKSWPLCNGELVPSNLSMETIIELSHRLTSGSAGILVTLLCILSWKYYKHVRETKPLAILSFVFLVAQALMGAAAVVWGQVPAVLAIHFGISLISFASVILLACLIFEIDKKFDARSLIMDKKMKFHIYGVTIYSYLVVYTGALVRHERASLACPEFPLCSKNRPWPTQLHEWVQMGHRVAAILLFAWIVYAMILAIRHYKQERVVYLGWITSFILVTLQAIVGILVVYTNASLTMALLHSLFISCLFAVLCYLVMLGTRSKVNAKQTTSTENKRFFS
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL32_VIBA3
Sequence: MAVQKSKKSRSMRGMRRSHDALTTAALSVDATSGETHLRHNVTAEGFYRGKKVINK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: GRPE_STRP8
Sequence: MAVFNKLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEETPEKSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDEHPADSIAEVFQKGYKLHERLLRPAMVVVYN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTU_BACC2
Sequence: MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYNAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFDGSLKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDKYTESLEEALAIANEYKEKKEPISIGLLGNAAEILPELVNRNIIPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGASWVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGIVRHVDAGYDLAVETAKEKGVNIPMMK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDPA_ECO57
Sequence: MSLDINQIALHQLIKRDEQNLELVLRDSLLEPTETVVEMVAELHRVYSAKNKAYGLFSEESELAQTLRLQRQGEEDFLAFSRAATGRLRDELAKYPFADGGFVLFCHYRYLAVEYLLVAVLSNLSSMRVNENLDINPTHYLDINHADIVARIDLTEWETNPESTRYLTFLKGRVGRKVADFFMDFLGASEGLNAKAQNRGLLQAVDDFTAEAQLDKAERQNVRQQVYSYCNEQLQAGEEIELESLSKELAGVSEVSFTEFAAEKGYELEESFPADRSTLRQLTKFAGSGGGLTINFDAMLLGERIFWDPATDTLTIKGTPPNLRDQLQRRTSGGN
What are the official names of this protein?
Nucleoid-associated protein YejK.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: VGF_VAR67
Sequence: MSMKYLMLLFAAMIIRSFANSGNAIETTLSEITNTTTDIPAIRLCGPEGDRYCFHGICIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSYIPSPGIVLVLLVSIIVCCLLFVYRFTRRTNKLPLQDMVVP
What is the function of this protein?
Stimulates cellular proliferation (hyperplasia)and mobility around infected cells to promote rapid and efficient spread of infection.  This effect is beneficial for virus replication in vivo, because poxviruses replicate possibly better in proliferating cells than in quiescent cells.  Acts by binding host EGFR, inducing its dimerization, autophosphorylation and leading to activation of several cellular pathways regulating cell proliferation or cell survival.  The activation by host EGFR of mitogen activated protein kinases (MAPK) and extracellular-signal regulated kinases (ERK) are essential for the positive effect of vaccinia growth factor on poxvirus virulence in vivo.
What are the official names of this protein?
Pro-variola growth factor, Pro-VGF.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG019 family.
What are the subcellular locations of this protein?
[Pro-variola growth factor]: Host membrane. SUBCELLULAR LOCATION: [Variola growth factor]: Secreted.
Protein: TACY_STRR6
Sequence: MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWDELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Pneumolysin, PLY, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Host cell membrane; Multi-pass membrane protein. Note=Probably secreted as soluble protein by the accessory Sec system (By similarity). It then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands (By similarity).