PharMolix/UniProtQA huggingface dataset:
Protein: PNP_SYNC1
Sequence: MAYQKVECQFNGQTLTLETGKMARQADGAVVVSFGGTKVLCTAVSAKQMREGQSFFPLTVNYQEKFYAGGKIPGSFFRRERGATERETLVCRLIDRPLRPLFPKGYMFETQIMPTVISVDEQNDPDTLAMVGASAAIAVSDIPFDGPVAAVRVGRVEGNLIANPTIEQRAESDMDIIVSGSRDAIIMVEGETRFISEQEMLDALFFAHEAIQPLIDVQLELVKIAGKEKREFSVPEIDPAVVEKVAELAETRLSEAVKIRTKQDRYAAVAEIKTEILETLAADFEDQEDDISEAFGNLQKRLVRQMVARDKVRIDGRDKNTIRPITCEIGLLPRAHGSALFTRGETQALVAAALGTSKDEQRMDNVQSMEFKKFMLHYNFPPFCVGETSMRLFPGRREIGHGMLAERSIAQVLPNHDDFPYTLRVVSDILESNGSSSMASVCGASLALMDAGVPVSEAVAGIAMGLIKEGDDIVVLSDILGDEDHLGDMDFKVTGTREGITALQMDIKIKGVSKEIMQQALEQAREGRLHILDKMAEAITAPRSDLSPYAPRITTIQVKPDQVRTVIGPGGKNVRGIIEATGCAIDIEDDGRINIASADGDACKAAIKMIRNLTQEAVVGKLYMATVKKIMEFGAFVEIFPGTEGLVHISELAKERVKKVTDILQEGDQVLVKCLDIDRQGKIKLSRKEALGQSLPEEG
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_PORPU
Sequence: MVSTTKSTGSVTQIIGPVLDIAFPNGQLPKVFNALKVQSTDGTITCEVQQLLGDNKVRAVSMSSTEGLKRGVEVVDTGAPISVPVGTNTLGRIFNVLGEPVDNLGPVSSESTLPIHRPAPAFTKLETKPSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESKVINEDNLKESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDINKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLATEMGALQERITSTTEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRNLAAKGIYPAVDPLDSTSTMLQPGIVGTDHYSTAQEVKSTLQRYKELQDIIAILGLDELSEEDRQTVSRARKIERFLSQPFFVAEVFTGSPGKYVSLEDAIKGFQMILKGELDDLPEQAFYLVGDIDEAIQKADSMKD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: DCUP_BRUMB
Sequence: MNLKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHALGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGFPKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGITPQAPIENVQRMIDRVRGGKS
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_NEIG1
Sequence: MTQYTLKQAGSLLQSKQISAVELASAYLAAIAEKNPALNGYITIDQDKTLAEARAADERIAQGNASALTGVPVAYKDIFCQTGWRSACASKMLDNFIFPYTATVVQNLLDEGMVTLGRTNMDEFAMGSTNENSFYGAAKNPWNPEHVPGGSSGGSAAVVAARLAPAALGSDTGGSIRQPASHCGITGIKPTYGTVSRFGMVAYASSFDQAGPMAQTAEDCAILLNAMAGFDPKDSTSFEREKEDYTRDLDKPLKGVKIGLPKEYFSEGNSTDVQTALQNTIDLLKAQGAELVEVSLPQTKLSIPAYYVLASAEAGTNLSRYDGVRYGHRAAQFGDLEEMYGKTRAEGFGSEVKRRIMIGTYVLSHGYYDAYYLKAQKLRRLVADDFQTAFARCDLILAPTAPSAAPKIGADTSPVETYLSDIYTIAVNLAGLPALTLPAGFSGGGLPVGVQLVGNYFAEAKILGAAHQIQLNSDWHGKRPE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: GSDMA_MOUSE
Sequence: MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVHTDYTLLDVLEPGSSPSDPTDSGNFSFKNMLDARVEGDVDVPKTVKVKGTAGLSRSSTLEVQTLSVAPTALENLHKERKLSADHPFLKEMRERGENLYVVMEVVETLQEVTLERAGKAEGCFSLPFFAPLGLQGSVNHKEAVTIPKGCVLAYRVRQLMVNGKDEWGIPHICNDSMQTFPPGEKPGEGKFILIQASDVGEMHEDFKTLKEEVQRETQEVEKLSPVGRSSLLTSLSHLLGKKKELQDLEQTLEGALDKGHEVTLEALPKDVLLSKDAMDAILYFLGALTVLSEAQQKLLVKSLEKKILPVQLKLVESTMEKNFLQDKEGVFPLQPDLLSSLGEEELILTEALVGLSGLEVQRSGPQYTWDPDTLPHLCALYAGLSLLQLLSKNS
What is the function of this protein?
Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:35110732).  Released upon cleavage by bacterial effector protein SpeB, and binds to membrane inner leaflet lipids (PubMed:35110732).  Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity).  Pyroptosis triggers the elimination of the infected skin cell, depriving the pathogen of its protective niche, while inducing an inflammatory response (PubMed:35110732, PubMed:35545676).  This ultimately prevents bacterial penetration of the epithelial barrier and a subsequent systemic dissemination of the pathogen (PubMed:35110732, PubMed:35545676).  Binds to cardiolipin and other acidic phospholipids, such as phosphatidylserine, which mediate its targeting to the inner leaflet membrane (By similarity).
What are the official names of this protein?
Gasdermin-A, Gasdermin-1, Gasdermin-A1.
What is the protein family that this protein belongs to?
Belongs to the gasdermin family.
What are the subcellular locations of this protein?
[Gasdermin-A]: Cytoplasm, perinuclear region. Cytoplasm, cytosol. SUBCELLULAR LOCATION: [Gasdermin-A, N-terminal]: Cell membrane; Multi-pass membrane protein.
Protein: ACPS_AGRRK
Sequence: MIIGIGSDLIDIRRVEKSIERFGTRFTERCFTDIERAKSEGRKNKAASYAKRFAAKEACSKALGTGLAQGVFWRDMGVVNLPSGKPTMQLTGGAARRLAAMLPENHRAAIHLTITDDFPLAQAFVIIEALPIAG
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCNA_HALS3
Sequence: MFKAIVSADTLQETLDSVSVLVDECKIHLDDDTLSIRAVDPASVGMVDLDLAATAFESYEADGGLIGVNLSRLEDIAGMADAGQLIQLELDEETRKLHIQIDGLEYTLALIDPDSIRQEPDIPDLDLPAHVAIEGRDIDRAVTAADMVSDHIALGVDTGDDLFYVNAEGDTDDVHLELAPDQLIDLDAGDAHSLFSLDYLKDMNKAIPTTAEVELELGDEFPIKLHFDIADAQGHVTYMLAPRIQSN
What is the function of this protein?
Sliding clamp subunit that acts as a moving platform for DNA processing.  Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
What are the official names of this protein?
DNA polymerase sliding clamp, Proliferating cell nuclear antigen homolog, PCNA.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: ACPH_PIG
Sequence: MERQVLLSEPEEAAALYRGLSRQPALSAACLGPEVTTQYGGRYRTVHTEWTQRDLERMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTMKAVLRKAGGTGTAEEKQFLEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSETHLLYVADKKRPKAESFFQTKALDVTGSDDEMARTKKPDQAIKGDQFLFYEDWGENMVSKSTPVLCVLDIESGNISVLEGVPESVSPGQAFWAPGDTGVVFVGWWHEPFRLGIRFCTNRRSALYYVDLTGGKCELLSDESVAVTSPRLSPDQCRIVYLRFPSLVPHQQCGQLCLYDWYTRVTSVVVDIVPRQLGEDFSGIYCSLLPLGCWSADSQRVVFDSPQRSRQDLFAVDTQMGSVTSLTAGGSGGSWKLLTIDRDLMVVQFSTPSVPPSLKVGFLPPAGKEQAVSWVSLEEAEPFPDISWSIRVLQPPPQQEHVQYAGLDFEAILLQPSNSPEKTQVPMVVMPHGGPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILSLPGNVGHQDVKDVQFAVEQVLQEEHFDAGRVALMGGSHGGFLSCHLIGQYPETYSACVVRNPVINIASMMGSTDIPDWCMVEAGFSYSSDCLPDLSVWAAMLDKSPIKYAPQVKTPLLLMLGQEDRRVPFKQGMEYYRVLKARNVPVRLLLYPKSTHALSEVEVESDSFMNAVLWLCTHLGS
What is the function of this protein?
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (By similarity).  It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity).  Also, involved in the degradation of oxidized and glycated proteins (By similarity).
What are the official names of this protein?
Acylamino-acid-releasing enzyme, AARE, Acyl-peptide hydrolase, APH, Acylaminoacyl-peptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_ANAD2
Sequence: MIQQQTMLDVADNSGAKRVMCIKVLGGTRRKYASIGDVIVVSIKEAIPQAKVKKGEVARAVIVRTAREVKRPDGSYIRFDGNSAVLINKDLEPIGTRIFGPVARELRARKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ARLY1_AGRFC
Sequence: MADGTDQKSSNQMWGGRFASGPSAIMEEINASIGFDKKLYAQDIRGSIAHATMLAEKGIISQEDKEKIVHGLNTILSEIEAGTFEFSRKLEDIHMNIEARLATLIGTAAGRLHTARSRNDQVALDFRLWVKEELQKTEGMLTALIAAFLDRAEENADTVMPGFTHLQTAQPVTFGHHCMAYVEMFGRDRARVRHAIEHLDESPIGAAALAGTGYPIDRHMTAKALGFREPTRNSIDTVSDRDFALEFLSIASICATHLSRLAEEIVIWSTPQFGFIRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRINGSLVALLTVMKGLPLAYSKDMQEDKEQVFDSAESLELAIAAMTGMIRDLEVRKDRMRAAAGSGYSTATDLADWLVREAGLPFRDAHHVTGNAVALAEKKGCDLADLSLEELQAIHPDITNGIFDVLSVEASVASRTSFGGTAPSEVRKQIAWWRGRN
What are the official names of this protein?
Argininosuccinate lyase 1, ASAL 1, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAGA8_HUMAN
Sequence: MLLGQKSQRYKAEEGLQAQGEAPGLMDVQIPTAEEQKAASSSSTLIMGTLEEVTDSGSPSPPQSPEGASSSLTVTDSTLWSQSDEGSSSNEEEGPSTSPDPAHLESLFREALDEKVAELVRFLLRKYQIKEPVTKAEMLESVIKNYKNHFPDIFSKASECMQVIFGIDVKEVDPAGHSYILVTCLGLSYDGLLGDDQSTPKTGLLIIVLGMILMEGSRAPEEAIWEALSVMGLYDGREHSVYWKLRKLLTQEWVQENYLEYRQAPGSDPVRYEFLWGPRALAETSYVKVLEHVVRVNARVRISYPSLHEEALGEEKGV
What is the function of this protein?
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
What are the official names of this protein?
Melanoma-associated antigen 8, Cancer/testis antigen 1.8, CT1.8, MAGE-8 antigen.
Protein: RPO11_METM5
Sequence: MNYVNIVEKSKNFIELELVNDDHSLSNLIKEVLLSKKGVILASYGVEHPVLDPDTGRYISNPTIMLKTDEKTDAEKVLKEALKDIVDLCNKTLKEL
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit L.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMPL1_MYCTO
Sequence: MRSQRLAGHLSAAARTIHALSLPIILFWVALTIVVNVVAPQLQSVARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYDVLVTKLSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQEARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPAIIAVASRFGLFDPKRATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKYQTNYNERYYIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLRNPTDMLILDRIAKTVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIENLQNLKDRVADLSTLTDQLQRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFWRPLRSFTYWERHCFDIPICWSMRSLLNSMDNVDKLTEDLANLTDDTERMDTTQRQLLAQLDPTIATMQTVKDLAQTLTSAFSGLVTQMEDMTRNATVMGRTFDAANNDDSFYLPPEAFQNPDFQRGLKLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTPLQAASIYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIWQHILHMPLHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMTPALATLLGRWFWWPRRVDRLARQPQVLGPRRTTALSAERAALLQ
What are the official names of this protein?
Probable transport protein MmpL1.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLNE_MYCA1
Sequence: MVVTKPATQRPRLPSVGRLGLVDPQAAERMAQLGWYDHDDQAHVDLLWALSRAPDPDAALLALVRLAETPDAGWDELGAALLTERPLRGRLFAVLGSSLALGDHLVAQPRSWKLLRGNVSLPTHDELCAMFTGCVDEALADPGSAMVRLRTLYRDRLLVLAALDLAATVEDEPVLPFTVVAAHLSDLADAALAAALRVAEHNVCGDRTPPRLAVIAMGKCGARELNYVSDVDVIFVGERADTVTTRVASEMMRLASEAFFQVDAGLRPEGRSGELVRTVESHIAYYQRWAKTWEFQALLKARAAVGDAELGRRYLDALMPMVWVACEREDFVVEVQAMRRRVEQLVPADVRGREIKLGSGGLRDVEFAVQLLQLVHGRSDESLHVASTVDALAALGQGGYIGREDAANLTASYEFLRLLEHRLQLQRLKRTHLLPEADDEEAVRWLARAAHIRPDGRHDAAGVLREELRHQNLRVSQLHAKLFYQPLLESIGPAGLEIRHGMTSEAAERQLAALGYEGPQSALKHMSALVNQSGRRGRVQSVLLPRLLNWMSYAPDPDGGLLAYRRLSEALAGESWYLSTLRDKPAVARRLMHVLGTSAYVPDLLMRAPRVIQDYGDGPSGPRLLETDPAAVARALVASASRYSDPVRAIAGARTLRRRELARVASADLLGMLEVTDVCKALTSVWVAVLQAALDAMIRANLPDDGPQRGKAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPAPGVDDSAAVRWAASVAEQVRTLLGTPSVDPPLDVDANLRPEGRNGPLVRTLASYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLLMADKTRYPADGVSPEAVREIRRIKARVDAERLPRGADPNTHTKLGRGGLADIEWTVQLLQLLHAHEVPALHNTSTLECLDAIAEAGLVPADEVDLLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWPTDEGGEFLDNYLRVTRRAKAVVRKVFGS
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: HAT4_ARATH
Sequence: MMFEKDDLGLSLGLNFPKKQINLKSNPSVSVTPSSSSFGLFRRSSWNESFTSSVPNSDSSQKETRTFIRGIDVNRPPSTAEYGDEDAGVSSPNSTVSSSTGKRSEREEDTDPQGSRGISDDEDGDNSRKKLRLSKDQSAILEETFKDHSTLNPKQKQALAKQLGLRARQVEVWFQNRRARTKLKQTEVDCEFLRRCCENLTEENRRLQKEVTELRALKLSPQFYMHMSPPTTLTMCPSCEHVSVPPPQPQAATSAHHRSLPVNAWAPATRISHGLTFDALRPRS
What is the function of this protein?
Probable transcription factor involved in the negative regulation of cell elongation and specific cell proliferation processes such as lateral root formation and secondary growth of the vascular system.  Acts as mediator of the red/far-red light effects on leaf cell expansion in the shading response.  Binds to the DNA sequence 5'-CAAT[GC]ATTG-3'.  Negatively regulates its own expression.
What are the official names of this protein?
Homeobox-leucine zipper protein HAT4, HD-ZIP protein ATHB-2, Homeodomain transcription factor ATHB-2, Homeodomain-leucine zipper protein HAT4, HD-ZIP protein 4.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class II subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECA_BURCH
Sequence: MTTGFLQKIFGSRNQRLVKQYQKTVATINALETQIEKLTDDQLRGKTDEFRQRVAAGESLDKLLPEAFAVCREASRRVLKMRHFDVQMIGGMVLHYGKIAEMRTGEGKTLVATLPVYLNALAGRGVHVVTVNDYLAQRDAEWMARLYNFLGLSVGINLSGMEHDQKQQAYAADITYGTNNEFGFDYLRDNMVYETDARVQRALNFAVVDEVDSILIDEARTPLIISGQAEDHTELYVRMNALPPLLERQIGEEKADGTGVEKPGDYTLDEKARQVFLTESGHEKAERLLAEWGLIGEGESLYAPQNITLMHHVYAALRAHTLFHKDQHYVVQNGEVVIVDEFTGRLMAGRRWSDGLHQAVEAKEHVKIQSENQTLASITFQNYFRMYAKLAGMTGTADTEAYEFNEIYGLETVVIPTNRPPKRIDKQDQIYKTAKERYDAVIRDIRDCYERGQPVLVGTTSIENSELLSHLLKQAGLPHEVLNAKQHEREAAIVAEAGRPKRITIATNMAGRGTDIVLGGNAEKQAAFIEADDAIPADEKARRIQKLHDEWETLHEEVKAAGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLDDPLLRIFAGDRVRSIMDRLKMPEGEAIEAGIVTRSIESAQRKVEARNFDIRKQLLEYDDVSNDQRKVIYQQRNELLEAHDITETITAMRHGVITEVVRQFVPEGSIEEQWDVPELEEALRNDWQLDLAIQEMVNESSSITAEEILDAVMTAADEQYEAKVAMVGRESFSAFERSVMLQTVDRLWREHLAALDHLRQGIHLRGYAQKNPKQEYKREAFELFAAMLDAIKQEVTRIVMNVQIQSPEQLEEAAEQIEERGGHLENVEYQHADYADAGAPVANVTAAAAATATADMVGSAMTHSGPGGEMPKVGRNDPCPCGSGKKYKQCHGKLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: BR2J_PELRI
Sequence: GIFLDKLKNFGKDVAGILLKKASCALSGQC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Brevinin-2Rj.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: NAA35_CHICK
Sequence: MVMKASVEDDDSGWELGMPDKMEKSNTDWVDITQDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMIGNQVNRKVLNFEQAIKDGTIKIKDLTSPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEEDFQSMTYGFKMANSVTDLRVTGMLKDVEDDMQRRVKSTRSRQGEERDPEVELEHQQCLAVFSRVKFTRVLLTVLIAFTKKETSAVAEAQELMTQAADLLSAIHNSCIHGIQAQNDTTKGDHPIMMGFEPLVNQRLLPPTFPRYAKIIKREEMVNYFSKLIDRIKTVCEVVNLTNLHCILDFFCEFSEQSPCVLSRSLLQTTFLVDNKKVFGTHLMQDMVKDALRSFVSPPVLSPKCCLYNNHQAKDYIDSFVTHCVRPFCSLIQIHGHNRARQRDKLGHILEEFATLQDEAEKVDAALHSMLLKQEPQRQHLACLGTWVLYHNLRIMIQYLLSGFELELYSMHEYYYIYWYLSEFLYAWLMSTLSRADSSQMAEERIMEEQQKGRSSKKTKKKKKVRPLSREITMSQAYQNMCAGMYKTMIAFDMDGKVRKPKFELDSEQVRYEHRFAPFNSVITPPPVHYLQFKEMSDLNKYSPPPQSADLYMAASKHFQQAKMILENIPNPDHEVNRILKVAKPNIVVMKLLAGGHKKDSKVPPEFDFSPHKYFPVVKLV
What is the function of this protein?
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.  Involved in regulation of apoptosis and proliferation of smooth muscle cells.
What are the official names of this protein?
N-alpha-acetyltransferase 35, NatC auxiliary subunit, Protein MAK10 homolog.
What is the protein family that this protein belongs to?
Belongs to the MAK10 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACLM_ASPOR
Sequence: MDAPLTDAERTALQTSLEALNRQVEATRNILRSNSQKALLQTLHTDQELPDPALEALAGKTINLLHETQQLLEPGHLVLADHFLGYVSTKCLCAAVELKLVDILADADEAGMTVDELADASGAHPDRLQQVLRVLRNDNIFDYDAVSHRYRNNRVSALLHSEHWTQWHNWVDLYGNEFYDIARGIPRSIRREEARWAAQINFDTNDDMFTYFQAQGWLPRLHRTLGGGAIAQAPGIVADYPWHEIGSRTVLDVGGGGGGFLASLLREYPQMRGGILDLPRTIEHACTLFHEPQGPYFDLRERVPRENLIAGDFLKAVPAFEIYTMKWVLHDWKDPDVLTILRCIRASLIPGPDSRLVILESNLSDGQMGRLSRYGDINMMMTANGQERSEEQWRALAAASGWEVSRIYPMRRAWVCAIDLRPSASESGDRKHS
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells (PubMed:25302411).  The non-ribosomal peptide synthetase (NRPS) aclP is responsible the formation of the diketopiperazine (DKP) core from the condensation of 2 phenylalanine residues (PubMed:25302411).  One Phe residue is tailored into chlorotyrosine by hydroxylation and chlorination, whereas the second Phe undergoes an unprecedented C-C bond cleavage to be converted into glycine (PubMed:25302411).  After formation of the DKP, sulfur is incorporated into the DKP by conjugation with glutathione by aclG, followed by its stepwise degradation to the thiol by aclI, aclJ and aclK, and the dithiol oxidation by aclT (PubMed:25302411).  In addition, oxygenases (aclB, aclC, aclL and aclO) and O-methyltransferases (aclM and aclU) act as tailoring enzymes to produce the intermediate dechloroaspirochlorine (PubMed:25302411).  Ultimately, chlorination of dechloroaspirochlorine by the halogenase aclH is the last step in the aspirochlorine pathway (PubMed:25302411).
What are the official names of this protein?
O-methyltransferase aclM, Aspitochlorine biosynthesis protein M.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: MHPA_MYCS2
Sequence: MNSPGAVDVVIVGAGPVGLTLANILGGQGVRTLIIEERETLIDYPRGVGLDDESLRTFQSIGLVDAILPHTVPNQILRFYDANRRLLAEMAPPDARFGWPKRNGFVQPMVDAELLAGLDRFDHVEVMWGRRMQTIAEDADGVTVEVSGPDGPASVHAQYVVGCDGGRSATRHLMGVSFDGTTSSTRWVVIDLANDPLGHPNSEVGADPQRPYASISIAHGIRRFEFMIHADETDEQAEDPEFVAELLRPFVPHPDRVDVIRRRVYTHHSRIAGSFRKGRMLLAGDAAHLMPVWQGQGYNSGIRDAFNLGWKLAAVVRGQAGDALLDTYDAERRKHARAMIDLSTMVGRVISPTNRKVAALRDKLIRGASIVPTLKRYVLEMRFKPMPRYHEGAVYHAKPPTPASPVGTLFIQPRVDTREQDNVLLDDVLGTGFAVLCWNNNPRTLLGEAAFTRWKALGATFIAARPSTQLHWTKDDDPDVVIVGDRTGALKAFFDAHTESVLVLRPDRCIAGADIAQRAPELSTALFGILHLRQGGENGATGPVLYVPQPTAESSGTVGRAS
What is the function of this protein?
Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).
What are the official names of this protein?
3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase, 3-HCI hydroxylase, 3-HPP hydroxylase, Flavin-type monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: ATPL_BACC1
Sequence: MSLGVIAAAIAIGLSALGAGIGNGLIVSRTIEGVARQPELKGALQTIMFIGVALVEALPIIGVVIAFIVMNK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FISL_PSEAE
Sequence: MTTETLVSGTTPVSDNANLKQHLTTPTQEGQTLRDSVEKALHNYFAHLEGQPVTDVYNMVLCEVEAPLLETVMNHVKGNQTKASELLGLNRGTLRKKLKQYDLL
What are the official names of this protein?
Putative Fis-like DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: IF2_STAA2
Sequence: MSKQRIYEYAKELNLKSKEIIDELKSMNIEVSNHMQALEDDQIKALDKKFKKEQKNDNKQSTQNNHQKSNNQNQNKGQQKDNKKNQQQNNKGNKGNKKNNRNNKKNNKNNKPQNQPAAPKEIPSKVTYQEGITVGEFADKLNVESSEIIKKLFLLGIVANINQSLNQETIELIADDYGVEVEEEVVINEEDLSIYFEDEKDDPEAIERPAVVTIMGHVDHGKTTLLDSIRHTKVTAGEAGGITQHIGAYQIENDGKKITFLDTPGHAAFTTMRARGAQVTDITILVVAADDGVMPQTIEAINHAKEAEVPIIVAVNKIDKPTSNPDRVMQELTEYGLIPEDWGGETIFVPLSALSGDGIDDLLEMIGLVAEVQELKANPKNRAVGTVIEAELDKSRGPSASLLVQNGTLNVGDAIVVGNTYGRIRAMVNDLGQRIKTAGPSTPVEITGINDVPQAGDRFVVFSDEKQARRIGESRHEASIVQQRQESKNVSLDNLFEQMKQGEMKDLNVIIKGDVQGSVEALAASLMKIDVEGVNVRIIHTAVGAINESDVTLANASNGIIIGFNVRPDSGAKRAAEAENVDMRLHRVIYNVIEEIESAMKGLLDPEFEEQVIGQAEVRQTFKVSKVGTIAGCYVTEGKITRNAGVRIIRDGIVQYEGELDTLKRFKDDAKEVAKGYECGITIENYNDLKEGDVIEAFEMVEIKR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.