PharMolix/UniProtQA huggingface dataset:
Protein: PKS1_METAS
Sequence: MEHVIIKQPDTGGDSVRIFVFGDQTSCNLSNLQPLLLKRSNIYLVSFVDQVNCALRHEIARLTTAERRSFPAFSSIQNLVTRGLQKERSVALESTLATIYQLCCFFNYFGDGQKSYPTGPNTHVSGLCIGALSAAAVSSSRSLDELVQAGIEAVLVSLKVGLLVSRTAALFSHQASANSSCSSSASWSYTVPDSQLPLALAEEAIASYTDKTNIPPLSSPYISARGQNSWTVSGPPAVLQGFLRSSQVVEAPRLTPLAVHAPYHAPHIFSVSDVENVIQAVGPVSSLSSKLPFISTSSCGSLSSGTRFQDLLFRAVEGILILPLDLRAAAENMRQVFEAVEDVSRCALIPISTGVCTSLKMSFSPVLADCVSIVDSIMEGTAADGGSKSAPATNPGDSKIAIIGMSGRFPEAADVEAFWAVLYKGLDVHRPVPKDRYDGELYYDPTGKKKNTCKVMHGCWINEPGLFDAKFFNISPKEAEQSDPGQRLALTTAYEALESAGVVAGRTPSTQRDRVGVFYGMTSDDYREVRASVCKPQCKPFPYTKANLTTGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWRNECDTAVAGGTNVMSNPDSFVGLDRGHFLSRKGNCNNFDDEADGYCRADAVATVVLKRLEDAMADHDPILGVISGAHTNHSAESVSITRPHSGAQEEIFSKLLCESGVHPHQVSYVEMHGTGTQAGDATEMTSVLNCFAPSTGPRRLPHESLHLGSAKANVGHSESASGVTSLIKVLLMMEKNMIPPHCGIKSKINHRFPTDLEQRNVHIAKTATRWGRRREFDNIRRVFVNNFSAAGGNTALLVEDYPPLAAASSQRDSRTAHVVTTSAKCIQSLRGNLEKLKAFVQKTSSSESFMSKLSYTTTARRMHHPFRVAIPAAKPEELLSALDTELRRDSCRCSSESAVAFVFSGQGSQYGAMGKHLLHYTIFRGEIDSYDILAQRHGFPSIMPLVDGSVAIEHLEPLVVQLGTVCVQMALASLWIAFGMQPSYVVGHSLGHFAALKVSGALTASDTIYLVGMRARLLQNKCSIGSHAMLAVRSSAEDVQAYLDADVHDIACINSPQDTVVSGRVDDIDRLSERLLDKGIKATRVNVPFAFHSSQVEPILDELGAIASQVKFHSPCVPIGCPLQGKSLLPGETLTSEASHVKRHCRQTVNFRGILQSAKSDGLVSEKTAWIEIGPHTVCSMLVKANINHDVTAVPSLMRSHDGWQVLASSLATLYSKGLSVAWDEYHHDFECCKEVLRLPAYSWDNKRYWIEYVHDWLLTRGDPPVPAAAPSPAPVSSFSTASVHRIVRESVDRETVALTAECEFTSEQLREVVYGHVVNGNRVCTSSLYADFGVTLGTYILDKYRADLKDHSVDVQEMVVNKPLVHKEGLPMLLRIDVVHDMTASKSATMSIYSINAKGNKTVDHAKSSLCFGESRAWLRSWDSTQYYVERSIEWLKEKADQGLNSRLSSGVIYKLFSSLVEYSSAYKGMKEAIVNTEDFEATALVQFQVDEGNFRCNPMWVDSCGQLAGFLMNGHSKTPLDQVFINHGWQSFRTVRKFCKDKTYRTYVRMRCIEGTTYAGDVYIFDDEGIVGVCGSITFQGVPRRVLDAAMPAPKSPNKTRDHASPNATISRAKPPQGSSPASSAQLAQHSSIEPLKLDAALKSATTAIDPMHAVLRILSEEIGIPLTSLQYDLVFADYGVDSLLSLTISGRLREELDLDIESSVFETCATVGDFAVHLGLDTLASYQSSGESNVSGGVSPRSDSVAAMSSDVTTPPAQSPLGSMSSSPCEDLCAIIAEEIGVSMSVIKSDANLGELGMDSLMSLTVLSRLREELDLDLEGDFFVAHPTYSSFKHVFEQEIEPEIGLGESADLKKYHATSTLLQGSPKSALYTLFLLPDGSGSATSYATISAVGRDICVYGLNCPWLKSAEKLVQFGLKGLASLYVGEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGEAVERLILLDSPNPIGLEKLPPRLFDFVNGLGLFGEGKAPDWLLAHFLAFIDALDQWKPVPWDKALDSTTPPPMTYILWAEDGLCKGIDARPEYRDDDPREMRWLLENRTNFGGNSWDILLGEGRLLTERIQDANHFTMLRRGKNAERVAAFIRSAFK
What is the function of this protein?
Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:29958281).  The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity).  The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity).
What are the official names of this protein?
Polyketide synthase 1, Conidial pigment biosynthesis polyketide synthase.
Protein: ADHS_META3
Sequence: MKMFNNIKNTGKLIRLERIFDKKSEKTVIIPMDHGVSSGPVAGLKDMRTAINSVAEGGANSVLVHKGIVRHGHRGYGKDIGLIIHLSAGTGVSPDPNEKVIVTSVEEAIRMGADAVSVHVNMGAPTDCQMYQDLGKIAETCEYWGMPLIAMMYPRGEKITDEKDPEFVAHAARLGAELGADIIKTNYTGDIDSFKDVVKGCPAPIIIAGGAKSTDAEYLQMVKDSIEAGGAGVASGRNVFQHKDVIGITKATAMVVHENADVEEALKVIKK
What is the function of this protein?
Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH).  Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
What are the official names of this protein?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase, ADH synthase, ADHS, ADTH synthase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
Protein: SYFA_CLOB6
Sequence: MRQKLEEIKNSAINELKASLSKDQLEVIRVKYLGKKGELTQILRGMGALSQEERPIVGKVANEVRSYIEETIKEAFSDIKNKEKSIRLENETIDITMPGKKQEVGKRHPLDLTLESMKDIFISMGFTIEEGPEVELDKYNFEALNIPKNHPARGEQDTFYINDNLVLRTQTSPIQIRTMENQKPPIKMIAPGKVYRSDSVDATHSPIFYQMEGLVVDKGITFSDLKGTLELFAKRMFGDKVKTKFRPHHFPFTEPSAEMDATCFVCNGEGCKVCKGSGWIELLGCGMVHPQVLRNCNIDPEVYSGFAFGFGVDRMVMMKYGIDDIRLLYESDMRFLNQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_YERE8
Sequence: MSVIKMTDLDLAGKRVLIRADLNVPVKDGKVTSDARIRASLPTIETALKQGAKVMVTSHLGRPTEGEYNEEFSLLPVVNYLKDKLSAPVRLAKDYLDGVEIAAGELVVLENVRFNKGEKKDDETLSKKYAALCDVYVMDAFGTAHRAQASTHGVGKFAPIACAGPLLSAELEALGKALGNPARPMVAIVGGSKVSTKLTVLGALSKIADQLIVGGGIANTFVAAQGNNVGKSLYEADLIPEAKRLLETCDIPVPTDVRVATEFSETATATLKPANQIKDDEQILDLGDESAERLAEILKNAKTILWNGPVGVFEFPNFRKGTEIVARAIAESEAFSIAGGGDTLAAIDLFGIADQISYISTGGGAFLEFVEGKKLPAVVMLEERAKQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAJ_CHLAT
Sequence: MQDFTKYLSTAPVLSALWFAILAGLLIEINRFFPDALLFPFG
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CAN3_BOVIN
Sequence: MPTVISASVAPRTGAEPMSPGPIAQAAQDKGTEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLFVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIVGGANRTDICQGDLGDCWFLAAIACLTLNKRLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDDCLPTYNNQLVFTKSNHRNEFWNALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIKDAPRDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLKMGELIERMVRNMDNSRLRDSDLIPEGCSDDRPTRMIVPVQFETRMACGLVKGHAYSVTGLEEALYKGEKVKLVRLRNPWGQVEWNGSWSDSWKDWSYVDKDEKARLQHQVTEDGEFWMSYDDFIYHFTKLEICNLTADALESDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSRTYINMREVSERFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKNKPIIFVSDRANSNKELGVDQETEEGKDNTSPDKQAKSPQLEPGNTDQESEEQRQFRNIFRQIAGDDMEICADELKNVLNRVVNKHKDLKTQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKTWQKIFKHYDTDQSGTINSYEMRNAVKDAGFHLNNQLYDIITMRYADKYMNIDFDSFICCFVRLEGMFRAFNAFDKDGDGIIKLNVLEWLQLTMYA
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease.  Proteolytically cleaves CTBP1.  Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.
What are the official names of this protein?
Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: PP390_ARATH
Sequence: MIRRLLIPNAAAKSHQYIKVSLFSTSAPEITPPFIHKCKTISQVKLIHQKLLSFGILTLNLTSHLISTYISVGCLSHAVSLLRRFPPSDAGVYHWNSLIRSYGDNGCANKCLYLFGLMHSLSWTPDNYTFPFVFKACGEISSVRCGESAHALSLVTGFISNVFVGNALVAMYSRCRSLSDARKVFDEMSVWDVVSWNSIIESYAKLGKPKVALEMFSRMTNEFGCRPDNITLVNVLPPCASLGTHSLGKQLHCFAVTSEMIQNMFVGNCLVDMYAKCGMMDEANTVFSNMSVKDVVSWNAMVAGYSQIGRFEDAVRLFEKMQEEKIKMDVVTWSAAISGYAQRGLGYEALGVCRQMLSSGIKPNEVTLISVLSGCASVGALMHGKEIHCYAIKYPIDLRKNGHGDENMVINQLIDMYAKCKKVDTARAMFDSLSPKERDVVTWTVMIGGYSQHGDANKALELLSEMFEEDCQTRPNAFTISCALVACASLAALRIGKQIHAYALRNQQNAVPLFVSNCLIDMYAKCGSISDARLVFDNMMAKNEVTWTSLMTGYGMHGYGEEALGIFDEMRRIGFKLDGVTLLVVLYACSHSGMIDQGMEYFNRMKTVFGVSPGPEHYACLVDLLGRAGRLNAALRLIEEMPMEPPPVVWVAFLSCCRIHGKVELGEYAAEKITELASNHDGSYTLLSNLYANAGRWKDVTRIRSLMRHKGVKKRPGCSWVEGIKGTTTFFVGDKTHPHAKEIYQVLLDHMQRIKDIGYVPETGFALHDVDDEEKDDLLFEHSEKLALAYGILTTPQGAAIRITKNLRVCGDCHTAFTYMSRIIDHDIILRDSSRFHHFKNGSCSCKGYW
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At5g16860.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
Protein: BETA_BRUO2
Sequence: MEADFVIIGSGSAGSAMAYRLSEDGRYSVIVIEYGVPDVGPLIQMPAALSFPMNMETYDWGFSSEPEPHIGGRSLVTPRGKVLGGSSSINGMVYVRGHACDFDHWSQSGARGWAYADVLPYFKRMENSQGGQEGWRGTNGPLYVQRGKRDNPLFHAFVEAGHQAGFEVTDDYNGEKQEGFGPMEQTIHNGRRWSAANAYLKPALKRPNVKLVKGFARKIVLEGKRAVGVEIEAGRTFSTIRARREVIIAASSINSPKLLMLSGIGPAAHLKEHGIDLVADRPGVGQNLQDHLEVYIQQECTQPITLYSKLNLFSKARIGVEWLLFKTGDGATNHFESAAFVRSKAGVEYPDIQYHFLPVAIRYDGKAAAQSHGFQAHVGPMRSKSRGSVTLRSANPREKPVIKFNYMSHEDDWADFRHCVRLTREIFGQAAFDPYRGAEIQPGAHVQTDDEIDNFIREHVESAFHPCGTCKMGAVDDPMAVVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMVGEKASDHILGRTPLARSNQEPWINPRWQVSDR
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: PTH1R_MOUSE
Sequence: MGTARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKAPGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLLPATTNGHSQLPGHAKPGAPAIENETIPVTMTVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
What is the function of this protein?
Receptor for parathyroid hormone and for parathyroid hormone-related peptide (PubMed:8197183).  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Parathyroid hormone/parathyroid hormone-related peptide receptor, PTH/PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
Protein: HDDA_CAMJE
Sequence: MKTIRTQTPLRLGLAGGGTDINLYCDKYTGYVLNATISLYIHCTLIKREDGKIIFDSPDTNSYCEYESKEFLGNDGKLDIFKSIYNRIVKDFTKKPLSFSLHTYSDVPSGSGLGGSSTLVVGVIKAFAEWLNLPLGEYEIAKLAYEIEREDLGIVGGAQDQYAATFGGFNFMEFYNNKRVIVNPLRIKNWIASELEARTVLYFTNITREAKDIEEHKKGKLGDEKSLEAMHAIKQDAIKMKEALFRADFGTLAQILGKSWRSKKIISEIVSNDELERIYKLAIDNGAYSGKTSGAGAGGFMFFFVDPTKKYNLIKALRKEQGYVQDFSFTKEGVKSWRI
What is the function of this protein?
Catalyzes the phosphorylation of D-glycero-alpha-D-manno-heptose 7-phosphate at the C-1 position to form D-glycero-alpha-D-manno-heptose 1,7-bisphosphate.
What are the official names of this protein?
D-glycero-alpha-D-manno-heptose 7-phosphate kinase, D-alpha-D-heptose 7-phosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family.
Protein: Y1048_SHEB5
Sequence: MLILVSPAKTLDFEQPPLTQVYSQPDFLTHSQELIQVCRQLAPSDIATLMKVSDKIAGLNAARFGEWQPDFSLDNAKQAIFAFRGDVYTGFDADSLSEDEIAQTQSQLRILSGLYGLLRPLDLIMPYRLEMGTALSNPKGKNLYEFWGDTLTQAVNEALAESGSDIIVNLASNEYFKAIKPKKLQGQLISPVFKDCKNGQYKVISFFAKRARGMMARYIITNKVNTLAELKAFNLAGYYYSEEQSSPTNPTFLRAE
What are the official names of this protein?
UPF0246 protein Sbal_1048.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: CYSA_MYCTU
Sequence: MTYAIVVADATKRYGDFVALDHVDFVVPTGSLTALLGPSGSGKSTLLRTIAGLDQPDTGTITINGRDVTRVPPQRRGIGFVFQHYAAFKHLTVRDNVAFGLKIRKRPKAEIKAKVDNLLQVVGLSGFQSRYPNQLSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREELRAWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVLHKGRIEQVGSPTDVYDAPANAFVMSFLGAVSTLNGSLVRPHDIRVGRTPNMAVAAADGTAGSTGVLRAVVDRVVVLGFEVRVELTSAATGGAFTAQITRGDAEALALREGDTVYVRATRVPPIAGGVSGVDDAGVERVKVTST
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FA8_CANLF
Sequence: MQVELYTCCFLCLLPFSLSATRKYYLGAVELSWDYMQSDLLSALHADTSFSSRVPGSLPLTTSVTYRKTVFVEFTDDLFNIAKPRPPWMGLLGPTIQAEVYDTVVIVLKNMASHPVSLHAVGVSYWKASEGAEYEDQTSQKEKEDDNVIPGESHTYVWQVLKENGPMASDPPCLTYSYFSHVDLVKDLNSGLIGALLVCKEGSLAKERTQTLQEFVLLFAVFDEGKSWHSETNASLTQAEAQHELHTINGYVNRSLPGLTVCHKRSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTFLMDLGQFLLFCHIPSHQHDGMEAYVKVDSCPEEPQLRMKNNEDKDYDDGLYDSDMDVVSFDDDSSSPFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPSGPTPNDRSHKNLYLNNGPQRIGKKYKKVRFVAYTDETFKTREAIQYESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGINYVTPLHTGRLPKGVKHLKDMPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFINLERDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSVFDENRSWYLTENMQRFLPNADVVQPHDPEFQLSNIMHSINGYVFDNLQLSVCLHEVAYWYILSVGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWVLGCHNSDFRNRGMTALLKVSSCNRNIDDYYEDTYEDIPTPLLNENNVIKPRSFSQNSRHPSTKEKQLKATTTPENDIEKIDLQSGERTQLIKAQSVSSSDLLMLLGQNPTPRGLFLSDLREATDRADDHSRGAIERNKGPPEVASLRPELRHSEDREFTPEPELQLRLNENLGTNTTVELKKLDLKISSSSDSLMTSPTIPSDKLAAATEKTGSLGPPNMSVHFNSHLGTIVFGNNSSHLIQSGVPLELSEEDNDSKLLEAPLMNIQESSLRENVLSMESNRLFKEERIRGPASLIKDNALFKVNISSVKTNRAPVNLTTNRKTRVAIPTLLIENSTSVWQDIMLERNTEFKEVTSLIHNETFMDRNTTALGLNHVSNKTTLSKNVEMAHQKKEDPVPLRAENPDLSSSKIPFLPDWIKTHGKNSLSSEQRPSPKQLTSLGSEKSVKDQNFLSEEKVVVGEDEFTKDTELQEIFPNNKSIFFANLANVQENDTYNQEKKSPEEIERKEKLTQENVALPQAHTMIGTKNFLKNLFLLSTKQNVAGLEEQPYTPILQDTRSLNDSPHSEGIHMANFSKIREEANLEGLGNQTNQMVERFPSTTRMSSNASQHVITQRGKRSLKQPRLSQGEIKFERKVIANDTSTQWSKNMNYLAQGTLTQIEYNEKEKRAITQSPLSDCSMRNHVTIQMNDSALPVAKESASPSVRHTDLTKIPSQHNSSHLPASACNYTFRERTSGVQEGSHFLQEAKRNNLSLAFVTLGITEGQGKFSSLGKSATNQPMYKKLENTVLLQPGLSETSDKVELLSQVHVDQEDSFPTKTSNDSPGHLDLMGKIFLQKTQGPVKMNKTNSPGKVPFLKWATESSEKIPSKLLGVLAWDNHYDTQIPSEEWKSQKKSQTNTAFKRKDTILPLGPCENNDSTAAINEGQDKPQREAMWAKQGEPGRLCSQNPPVSKHHQREITVTTLQPEEDKFEYDDTFSIEMKREDFDIYGDYENQGLRSFQKKTRHYFIAAVERLWDYGMSRSPHILRNRAQSGDVQQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIVVTFKNQASRPYSFYSSLISYDEDEGQGAEPRRKFVNPNETKIYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLICRSNTLNPAHGRQVTVQEFALVFTIFDETKSWYFTENLERNCRAPCNVQKEDPTLKENFRFHAINGYVKDTLPGLVMAQDQKVRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETVEMLPSQVGIWRIECLIGEHLQAGMSTLFLVYSKKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKDPFSWIKVDLLAPMIIHGIMTQGARQKFSSLYVSQFIIMYSLDGNKWHSYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIAQYIRLHPTHYSIRSTLRMELLGCDFNSCSMPLGMESKAISDAQITASSYLSSMLATWSPSQARLHLQGRTNAWRPQANNPKEWLQVDFRKTMKVTGITTQGVKSLLISMYVKEFLISSSQDGHNWTLFLQNGKVKVFQGNRDSSTPVRNRLEPPLVARYVRLHPQSWAHHIALRLEVLGCDTQQPA
What is the function of this protein?
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
What are the official names of this protein?
Coagulation factor VIII, Procoagulant component.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: DB132_HUMAN
Sequence: MKFLLLVLAALGFLTQVIPASAGGSKCVSNTPGYCRTCCHWGETALFMCNASRKCCISYSFLPKPDLPQLIGNHWQSRRRNTQRKDKKQQTTVTS
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 132, Beta-defensin 32, BD-32, DEFB-32, Defensin HEL-75, Defensin, beta 132.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECO_BEII9
Sequence: MEWHDEGLIIGLRRYGETGAILEVFTPAHGRHFGLVRGGFGRRLRALLQPGNQADFTWRARLDQQLGLLAVEPTKLMTTRLFASGLALQGMNLIAALLRLLPERDPHPELYAVVRVLLEHLDEPAVAPILLARFELAMLTETGFGLDLSACAATGATQELIYVSPKSGRAVSARAGAPYHDKLLGLPPFFLDGSLLKNPTLEEVEAGFALTGHFLMRDLFGPRGQTLPDARHAFLAETAKTYPRVAPQCF
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: ENY2_DROSE
Sequence: MSISSAVDQYTVLTGDRSKIKDLLCSRLTECGWRDEVRLMCRNILIEKGTNNSFTVEQLIAEVTPKARTLVPDAVKKELLMKIRTILTEIEEEADEPEDES
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes.  The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Involved in transcription elongation by recruiting the THO complex onto nascent mRNA.  The AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
What are the official names of this protein?
Enhancer of yellow 2 transcription factor.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm.
Protein: ATOSB_MACFA
Sequence: MRHVQAEPSPSSEPEAGPSQPPVRQGALQGGLLMGYSPAGGATSPGVYQVSIFSPPAGTSEPHRALKRQAPPTEGPRELKRGPGLGAREGLPPEEPSTVGLLGPEGLGLGLGVASQHFSHRGLCVVEQRSSVTSSWTSGTWSPPCPPSNASCNTLHTRDWASPDPGGHGSLGESPGPAPPGQLHTLDTDLHSLAQIGGKSPVAGVGNGGSLWPRESPGTANGHSPEHTPPGPGPPGPCPTKRRLLPAGEAPDVSSEEEGPAPRRRRGSLGHPTAANSSDAKATSFWSHLLPGPKEPVLDPTDCSPMGRRLKGARRLKLSPLRSLRKGPGLLSPPSASPVPTPAVSRTLLGNFEESLLRGRFAPSGHIEGFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGIVDLNPLGRKGYSVPKVGTVQVTLFNPNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVGEEGNANPTHRLLCYLLHLRFRSSRSGRLSLHGDIRLLFSRRSLELDTGLPYELQAVTEAPHNPRYSPLP
What is the function of this protein?
Transcription regulator that may syncronize transcriptional and translational programs.
What are the official names of this protein?
Atos homolog protein B.
What is the protein family that this protein belongs to?
Belongs to the ATOS family.
Protein: HSCA_RUTMC
Sequence: MALLQISEPGQVSAIHQHKLAIGIDLGTTNSLVASVMSGQSKVLIHENNETILPSVVHCGKDNKLTVGCNAYHYAKTDPTNTIISVKRFMGMSYKEVSTFKNCPYQLLENGNNVLFHTATGDLSAVEISASILASLKQCAEKSLGGALFGAVITVPAYFNDAQRQATKDAATLAGLKTLRLLNEPTAAAVAYGLESGEEGVHAIYDLGGGTFDISILSFSKGVFKVLAISGDSTLGGDDFDALIVDDCIKQLGINKLTPTQMQKIKQFSRTAKETLSNHEFAKFNCIEKSYRITKKKFEILAKVLIKRTLLLTKRAIRDAQVDVEDIKDIIMVGGSTRMPLVRFMVSDLFNKPVLCSINPDEVVAKGAAIQANILAGNKSQGDVLLLDVLPLSLGLETMGGLVEKVIHRNTTIPIIRAQEFTTFKDGQTAMSVHVLQGERELVKDCRSLAKFDLQGIPPMVAGSARIQIEFQVDTDGLLSVSAVEQISGVKTNITIKPSYGLTDVQMEKMLKDSILFAKTDIQTRQLHETQVEANRTIQAIDLALKKDKHMLDVKMLNNILTARTILFNMAHSDDEKAIKTALENLENTCSKFVEMRMNNTVMKAMQGHNVDEF
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CLPX_RHIEC
Sequence: MSKVSGSNGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSMVKSRDGVPTPQDIIKVLDEYVIGQRQAKKILSVAVHNHYKRLAHASKNGEVELAKSNIMLVGPTGCGKTYLAQTLARIIDVPFTMADATTLTEAGYVGEDVENIILKLLQAADYNVERAQRGIVYIDEVDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLDKIISARGEKTSIGFGATVKAQDDRRVGEVLRELEPEDLVKFGLIPEFIGRLPVLATLEDLDEDALIQILSEPKNALIKQYQRLFEMEDVELTFHEDALREIARKAIVRKTGARGLRSIMEKILLDTMFELPTLEGVREVVISEEVVRGSARPLYIYADRQEEKANASA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: GPER1_DANRE
Sequence: MEEQTTNVIQIYVNGTEQFNASFDFNITDVKESTDTYEFYIIGLFLSCLYTIFLFPIGFIGNILILVVNLNHRERMTIPDLYFVNLAVADLILVADSLIEVFNLNEKYYDYAVLCTFMSLFLQVNMYSSIFFLTWMSFDRYVALTSSMSSSPLRTMQHAKLSCSLIWMASILATLLPFTIVQTQHTGEVHFCFANVFEIQWLEVTIGFLIPFSIIGLCYSLIVRTLMRAQKHKGLWPRRQKALRMIVVVVLVFFICWLPENVFISIQLLQGTADPSKRTDTTLWHDYPLTGHIVNLAAFSNSCLNPIIYSFLGETFRDKLRLFIKRKASWSVVYRFCNHTLDLQIPVRSESEV
What is the function of this protein?
Membrane G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways.  Plays a role in the embryonic development of sensory and motor neurons.  Specifically induces apoptosis and reduces proliferation of brain cells.  Involved in maintenance of meiotic arrest in oocytes.
What are the official names of this protein?
G-protein coupled estrogen receptor 1, G protein-coupled estrogen receptor 1, G-protein coupled receptor 30.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell projection, axon. Postsynaptic density. Mitochondrion membrane; Multi-pass membrane protein. Note=Colocalized with cadherin at the plasma membrane.
Protein: EFP_SALNS
Sequence: MATYYSNDFRSGLKIMLDGEPYAVESSEFVKPGKGQAFARVKLRRLLTGTRVEKTFKSTDSAEGADVVDMNLTYLYNDGEFWHFMNNETFEQLSADAKAIGDNAKWLLDQAECIVTLWNGQPISVTPPNFVELEIVDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQIGEVIKVDTRSGEYVSRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_ACIBT
Sequence: MQDTPLIIGSRSFQSRLLVGTGKYKDLNETDLAIQASGAEIVTVAIRRVNIGQNPDQPNLLSVIPPEKYTILPNTAGCFDADSAVRTCMLARELLDGHNLVKLEVLGDEKTLYPNVTETLKAARTLIDDGFEIMVYTSDDPIIAQELESMGCVAIMPLGSLIGSGLGILNPHTISIIKENAKVPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAAAQNPILMASAMKKAVEAGREAFLAGRMPRKRMANASSPETGYFFK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_TRIEI
Sequence: MANNEVIENTWLERPSPEVAPELIGCTLVRRISEEKIIRSTIVETEAYAPGDPACHAYRKRTPRNTVMFGPPGISYVFLIYGMYHCLNVVTDIDGIPSVVLIRALQLESVPNWLWEHIPKQKSKPKVSRLAAGPGKLCRLLNIDLNLNGSRLRAGQPMWLEQRSPSFEKNLQIVQTTRIGITKGTNLLWRWYLANCDAVSK
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.