PharMolix/UniProtQA huggingface dataset:
Protein: TDA3_YEAST
Sequence: MGEDFMHPPFQTYPSKNSEGKKHIVIVGGGIIGCCTAYYLTQHPSFSPSTHHITIIESRRIAGGASGKAGGLLASWAFPHQIVPLSFQLHQELSDEYDGENNWDYRRLTTVSLEADVREEVIENYERLSKKAYNLNVPPPKKRPGYISNKFNIGDSNSSLSSSGSSLKNDSASNEEEGSDIHVSSSVPSLHSLTNERMRSHTNSASDLDSVSPVEQLRETNIHNPLPADLDWIRRELVNDWSSLGGTDTTAQLHPYKFTHFILSKAMETGAVDLLLGKVVGLKCDEMDCVHSLKYLPSVVKNRRNSRGHAENPDIKLGTIFNDENAKPIEINDIQQIVLSMGPWTSKILKDCPISGLRAHSVTIKPSEKTVSPYAILAELKVNDREFFSPEMYARKDEVYVCGEGDTLVNIPESSDDVEVVSEKCDELYHYVSKLSPTLSKGHLLRKQACFLPVLNVPTSSGPLIGETNVKDLYIASGHSCWGINNAPATGKLMAEILLDGEATSAEISSLDPKLYFDATILS
What is the function of this protein?
Putative oxidoreductase that negatively regulates the retrieval of cargo from late endosomes to the Golgi.  Regulates YIF1 and KEX2 localization.  Required for fast DNA replication.
What are the official names of this protein?
Putative oxidoreductase TDA3, Batten disease protein 3, Topoisomerase I damage affected protein 3.
What is the protein family that this protein belongs to?
Belongs to the TDA3 family.
What are the subcellular locations of this protein?
Cytoplasm. Late endosome. Note=The recruitment from the cytoplasm to endosomal structures is facilitated by BTN2.
Protein: LEU1_CROS8
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTLPFEFSNIISGLYERVPNIDKAVISVHTHDDLGMAVGNALAAVQAGARQVEGTLNGIGERAGNCALEEVIMAIKLRQNLMNVHTRINHQEIWRTSQTVSQICNMPIPANKAVVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYHENDYNLDDLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLEYFSVQSGSNAMATASVKLACGEEIKAEAANGNGPVDAVYQAINRITDYDIELVKYQLGAKGHGKNALGQVDIVVSYNGRHFHGVGLTTDIVESSARAMINVLNNIWRAGEVEKELQRKAQNKEHNQETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: FMT_STAA8
Sequence: MTKIIFMGTPDFSTTVLEMLIAEHDVIAVVTQPDRPVGRKRVMTPPPVKKVAMKYDLPVYQPEKLSGSEELEQLLQLDVDLIVTAAFGQLLPESLLALPNLGAINVHASLLPKYRGGAPIHQAIIDGEQETGITIMYMVKKLDAGNIISQQAIKIEENDNVGTMHDKLSVLGADLLKETLPSIIEGTNESVPQDDTQATFASNIRREDERISWNKPGRQVFNQIRGLSPWPVAYTTMDDTNLKIYDAELVETNKINEPGTIIETTKKAIIVATNDNEAVAIKDMQLAGKKRMLAANYLSGAQNTLVGKKLI
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: DNAJ_HAEI8
Sequence: MAKKDYYEVLGLQKGASEDDIKRAYKRLASKHHPDKNQGSKEAEEKFKEINEAYEVLGDDQKRAAYDQYGHAAFEQGGGTGGFGGGFGGADFGDMFGDIFGDIFGGGRGRQRVVRGEDLRYDLEISLEEAVKGTTKDIQINTLAHCDSCGGSGAEKGSKVETCPHCHGSGRIRRQQGFFVSESICPTCHGSGKKIEKPCRSCHGEGRVHKKENLSVKIPAGVDTGNQLRLAGKGAAGENGAPAGDLYVVIHVREHNIFERDGSNLYCEVPISFATAALGGEIEVPTLDGRVKLKIPAETQTGKLFRMRGKGVASTRSGYAGDLICRIVVETPVNLTSEQKELLHKLEESLQGKDLSKHAPKSSGFLDGVKKFFDNLGKSDK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_BACHK
Sequence: MYLINQNGWIEVICGSMFSGKSEELIRRVRRTQFAKQHAIVFKPCIDNRYSEEDVVSHNGLKVKAVPVSASKDIFEHITEEMDVIAIDEVQFFDGDIVEVVQVLANRGYRVIVAGLDQDFRGLPFGQVPQLMAIAEHVTKLQAVCSACGSPASRTQRLIDGEPAAFDDPIILVGASESYEPRCRHCHAVPTNKDK
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y6KD_STRLI
Sequence: MTDFDGRLTEGTVNLVQDPNGGGWSAHCAEPGCDWADFAGPLGFQGLVAIARRHTH
What are the official names of this protein?
Uncharacterized 6.0 kDa protein, ORF 56.
Protein: ASPA_SYNSC
Sequence: MSSCGVLVVAGTHGNEVNAPWLLQQWQANPDLIDAAGLAVQKVIGNPEALRRRCRYVDRDLNRCFLPEQLEQGASGLEFQRAGELLRLHGPSGEQPCAVAIDLHSTTAAMGNSLVVYGRRPADLALAALVQGALGLPIYLHEADAQQTGFLVESWPCGLVIEVGPVPQGLLNAGVVEQTRLGLESCLRALYQVRQELARLPDALVVHRHLGSRDLPKAENGEPQALVHPELQGRDWQNIASTQAMFRAADGTDRCEAWVGGEIPVFVNEAAYAEKSIAFSLTRREVWPVEPNWLLALKQLLAAA
What are the official names of this protein?
Probable aspartoacylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Protein: VNN1_HUMAN
Sequence: MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
What is the function of this protein?
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
What are the official names of this protein?
Pantetheinase, Pantetheine hydrolase, Tiff66, Vascular non-inflammatory molecule 1, Vanin-1.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: AV241_PHYSP
Sequence: MRQYCLLLIVLALAAALSDNAVASTLAVARSEIGAPSAVYSERLLRSEPQDEDTFEDRAFGLNWLRLRWLRLGAAKAKTTDVISARESKWIEAWANKNLSPNYVYKQLGLAKQGDKAMQSQNYRIFEAYTERLFAKDQALYTKWLDAKMTPEDVYKALKLDKLLGAKAANSPDFRRYEVYMFKWHELN
What is the function of this protein?
Effector that triggers cell death in a variety of plant species (including tobacco, tomato and soybean), regardless of the Rps genes present (PubMed:22816601).  Avh241 interacts with the plant immune system via at least two different mechanisms, one recognized by plants dependent on subcellular localization and one promoting infection independent on membrane localization (PubMed:22816601).  The cell death triggered by Avh241 in N. benthamiana requires the two host mitogen-activated protein kinases, MEK2 and WIPK (PubMed:22816601).
What are the official names of this protein?
RxLR effector protein Avh241, Avirulence homolog protein 241.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane.
Protein: NU5M_BRALA
Sequence: MLELWGVLSLTSLGVMVIFLFSKIKSSFAESVKYAGYMNAVLLSILLMSDESEMLFLKWEWVKLGGYSLMISFRFDLYTCCFFVVGLYVTWNILMFSFYYMSTDPRIDLFCKYLGLFLIAMLLLVSAESLFQLLIGWEGVGIMSYLLISWWYARSDANTAALQAIFYNRVGDIGLLIMLMWSLVTLGDWSFTGLYALDFVNTFFLLGVVLAAAGKSAQLGLHPWLPAAMEGPTPVSSLLHSSTMVVAGVFLLIRFSPIILNHKEIQLMVFFLGTMTTLFSAICALAQNDMKKVVAFSTASQLGLMVTAVGAGAPQLAFLHICMHAFFKAMLFMCSGSFIHGLQNEQDVRKMGGLYSAAPITSVCFFIGSAALMGVPFLAGFFSKDPIIEIININNLNSWAVGLVLIATSFTAAYSVRLLYFSVGGVSRMLVLQPMNEEYGNLIGPLQRLAYSSVIAGVVFIYFLSPNQISCLSLPLSLKLAAVFVTLVGGLIAWDVVNLLHREESVTNIPELAFEAQVGFYPLIMHKLIPKVWLNMGEMYQMQVMDRGWTELALPQGLGGNYKIMADNVVNAQTSLIKMYIAVMVMMGGLILGIMICL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PSRP_ACIBS
Sequence: MSESKQFKRSVFFISDGTAITAETLGHSLLAQFPNVDFDIHIMPYITTEEAAMAVVVEINKCQTRDGCLPLVFDTLVDPHVREIINTAKAVNLDVFEGLISKLEQELGTPPTTLVGQTHAVTDSEYYKARIDAVHFALDNDDGARTRHYDKADLILIGVSRSGKTPTSIYLSLQFGIRVANYPLTEEDLDDNRLPAVLREHRSKLFGLMIDAERLVAIRSERKANSRYASFSQCQMELRAIEGIYISEGIKYLNVTEMSIEEISTRILQMTGLKRRIG
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: 3MGH_ANAD2
Sequence: MKLPQAFYARDTRTVARALLGKVLVHLDGGVRRAARIVETEAYHGPDDRASHARAGPTPRAAIMFGPPGRAYVYLIYGTSHCMNVVTGPEGFPSAVLLRAAEPIDGCLHSTRGPGNLCRALAIRREHDNGRDLAGDDLFVEDAPPPSEAVVTGPRVNVGYAGAWAARPWRFALRGSPWVSRPPPGAAAARAARAPAAPAPRPRRPRGSGP
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: DPH1_CRYNB
Sequence: MPVPVDDSTAVLEPTEGIERPTKPAVKSRKRFVGSSKAATSRPVVRRVANQVPDDILHDKELNAAIAALPGNYNFEIHKTIYHIRRDNVQSVALQMPEGLMMYGCAIADIIERFTGALPMMLADVTYGACCIDDYTAKEMGAEMIVHYGHSCLIPVSQTTLKTLYVFVEIGIDTPHLSLSVRRNFPSSRSAFQRLILGAGEAAPGGKVPIALESTDESAQATPDLSTNDLPTRLALVSTIQFVAATQALRADLETAMPPLEKGEIEQEEEGMVAKVKRGDIGVWRGKYEVTVPQAKPLSPGEVLGCTAPKLNDVDALIYVGDGRFHLESIMIANPTVPAFRYDPYSKKFTREVYDHTEMRGLRGEAVKAARKNLDDQGSGSWAVLLGTLGRQGSLAVLKSIQNSLPADSLPPLLLLLSELSPAKLALLPNSQISTFIQTSCPRLSIDWGYAFSRPLLSPYEASVAVGRVKGWGGLSLDNGKEGGKLEGEGDYPMDFYADNSLGDWTPRHNPPRPRPARVRPQAQGCAQD
What is the function of this protein?
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1, Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUMH_HUMAN
Sequence: MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK
What is the function of this protein?
Catalyzes the dehydration of L-malate to fumarate (By similarity).  Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity).  Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed:20231875, PubMed:26237645).  In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed:26237645).
What are the official names of this protein?
Fumarate hydratase, mitochondrial, Fumarase, HsFH.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
[Isoform Mitochondrial]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm, cytosol. Nucleus. Chromosome. Note=Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC.
Protein: VPC45_MYCTO
Sequence: MPLVYFDASAFVKLLTTETGSSLASALWDGCDAALSSRLAYPEVRAALAAAARNHDLTESELADAERDWEDFWAATRPVELTATVEQHAGHLARAHALRGADAVHLASALAVGDPGLVVAVWDRRLHTGAHAAGCRVAPAQLDP
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  Its cognate antitoxin is VapB45 (By similarity).
What are the official names of this protein?
Ribonuclease VapC45, RNase VapC45, Toxin VapC45.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: NRDI_ESCF3
Sequence: MSQLVYFSSSSENTQRFIERLGLPAVRIPLNERERIQVDEPYILIVPSYGGGGTAGAVPRQVIRFLNDEHNRALLRGVIASGNRNFGEAYGRAGDVIARKCGVPWLYRFELMGTQSDIENVRKGVTEFWQRQPQNA
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: TVA3_HUMAN
Sequence: MASAPISMLAMLFTLSGLRAQSVAQPEDQVNVAEGNPLTVKCTYSVSGNPYLFWYVQYPNRGLQFLLKYITGDNLVKGSYGFEAEFNKSQTSFHLKKPSALVSDSALYFCAVRD
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 3.
What are the subcellular locations of this protein?
Cell membrane.
Protein: MHPB_PHOLL
Sequence: MTVKLICTSHTPLMGFGSPPEATEKHVRQVFQQLAEQIKDYDPQLIVIFAPDHFNGFFYDLMPAFCVGVRANAVGDWDIGKGPLNVPENTAKDLISALYDSGIDVAHSWRMQVDHGFTQPLMLLCQNLQRYPTIPIFINCAAKPLPTCRRAVELGRAVGQFLFTTDQRVLLLGSGGLSHDPPIPQMGQVPPEVEEGLIAGRNPTKEARQKRQIRVIEVGKSLARGENIVAPLNPQWDDELLRIFCSGDIRRLASLTEGGIAIQGGKGGQEIRCWIAAFAALSVYGEYKAQRHYYQPIKEWLAGMAMVSAQPVTQIGA
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: PTMCB_STAHJ
Sequence: MAQTETQEKKGLGRKVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWYPNKELSQLAGPMITYLIPLLIAFSGGRLIHDLRGGIVAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKVDQFLQPRTPQGFEMLFNNFSAGILAFIMTILGFKLLAPIMQFIMHILSVAVEFLVHLHLLPIVSIIVEPAKILFLNNAINHGVFTPLGTDQAASAGQSILFAIESNPGPGIGILLAYMIFGKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPKGEFLHMVLGVFLAALVSFVVAALIMKFTKEPKQDLEAATAKMESTKGKKSSVSSKLTGATTGTGAAGVAANKANGEDQNEASSEDEEEDLLDNYNTEDVDAHDYSNVDHVIFACDAGMGSSAMGASMLRNKFKKAGISDVNVTNTAINQLPNNAQLVITQKTLTDRAIKQVPNAIHISVDNFLNSPRYEELLNNLKKDQDKA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II CmtAB PTS system is involved in D-mannitol transport.
What are the official names of this protein?
PTS system mannitol-specific EIICB component, EIICB-Mtl, EII-Mtl.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CTAA_WOLTR
Sequence: MEQKQSKSVAIWLFLCSIMIVLMVGIGGFTRLSKAGLSITEWNPITGAFPPLNERDWLQEKSKYETTPEYKTFNYGMSMEEFRTLYLIEYVHRLFARLTGLIFILPFIYFTLKKRISKKVVIRLSIALSFGVLQAFTGWYMVKSGLVAKPHVSHYMLTLHLLLALVIFALLSYQFFNYQVRQKQTKLKISGSTVHYVGIILILIVVQIIFGAFVAGLNAGLIYNTFPLMGGHIIPKDLFFLQPTWLNIFENRATVQFIHRTLALLILVLTTVLTIKNASVKSVYVMLLSVIIQIILGVVTLLLHIPITIAISHQMFSFILFGSGLCFLCYLRKQN
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEMH_CAMJR
Sequence: MKLVLFLNMGGATNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYKKMGGKSPLNELTQSLCDKLNLKQDEFKFDFVNLYVPPFATEILQKYTLNASDEIILFPLYPHHSCTTVTSSLEVLQNEISKQKIQAKVKTIDIFYKNELYNEMIVSHILDKKSKFDAKILIFSAHSLPQSIIDKGDLYEKHVNDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSDVLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNNSDEFMKFILKYLSDLN
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YM04_PARTE
Sequence: MFLLYSIMNTYFLFGTTDWATLNFLVSVCLDNDYLYNKNSLFFTFFIFFLAAVFKLGLPPFFFFKIEVYKGLPLFVTFFYSVFFFFNYLSGFFFLFFVFFTSFFVYFSYLLFFFVPVFVLFFFFYLTTYDNLNCFFSISSVINSTFLVYLLASSFF
What are the official names of this protein?
Uncharacterized mitochondrial protein ORF4.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SSPK_BACSU
Sequence: MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERMRASGKR
What are the official names of this protein?
Small, acid-soluble spore protein K, SASP K.
What is the protein family that this protein belongs to?
Belongs to the SspK family.
What are the subcellular locations of this protein?
Spore core.
Protein: DGUS2_AQUCR
Sequence: MSSAKLGSASEDVSRRDANYHPTVWGDFFLTHSSNFLENNDSILEKHEELKQEVRNLLVVETSDLPSKIQLTDEIIRLGVGYHFETEIKAQLEKLHDHQLHLNFDLLTTSVWFRLLRGHGFSIPSDVFKRFKNTKGEFETEDARTLWCLYEATHLRVDGEDILEEAIQFSRKRLEALLPKLSFPLSECVRDALHIPYHRNVQRLAARQYIPQYDAEQTKIESLSLFAKIDFNMLQALHQSELREASRWWKEFDFPSKLPYARDRIAEGYYWMMGAHFEPKFSLSRKFLNRIVGITSLIDDTYDVYGTLEEVTLFTEAVERWDIEAVKDIPKYMQVIYIGMLGIFEDFKDNLINARGKDYCIDYAIEVFKEIVRSYQREAEYFHTGYVPSYDEYMENSIISGGYKMFIILMLIGRGEFELKETLDWASTIPEMVKASSLIARYIDDLQTYKAEEERGETVSAVRCYMREFGVSEEQACKKMREMIEIEWKRLNKTTLEADEISSSVVIPSLNFTRVLEVMYDKGDGYSDSQGVTKDRIAALLRHAIEI
What is the function of this protein?
Sesquiterpene synthase involved in the biosynthesis of delta-guaiene (53. 7%) and alpha-guaiene (44. 6%), two structures composed of five- and seven-membered rings.  Produces also 1. 7% of alpha-humulene.
What are the official names of this protein?
Delta-guaiene synthase 2.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: PTH_MYCGE
Sequence: MPTYKLIVGLGNLGKKYEKTRHNAGFMVLDRLASLFHLNFDKTNKLGDYLFIKEKAAILAKPATFMNNSGLFVKWLQDHFQIPLANIMIVHDEIAFDLGVIRLKMQGSANNHNGIKSVIRHLDTEQFNRLRFGIKSQNTSNILHEQVMSEFQNSELTKLEVAITKSVELLKRYIEGEELQRLMEYYHHG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TR130_YEAST
Sequence: MDKEIYCGSVPVSYFDPFDLFESLRPEFQQILPLDNIHWKAFDGTVRTVNRLPIELIPEGRGEADKSNDEQPFIRFLIVNCISIDQYRAKVRPLVRQWLPNLESVSSSTGEKMIYKPIILLYANSEVVDSNLFKSVSLMEKFGKDFPHVQTLEVRSVYRSPKERQEFWNQFSQKIKASVLSIFQKRLTHLQHSLANLQKGNNFEEQLLTREKLYELYVVFNILEDASLELQKIKKEILRRNMNMPDGKLQVPFESSSKSDESLGSIIIEGTLDKFQLHKYFFIRRLRLLKLEDQTLTAFVGAFQLIKNFIESISIEYRKSVRLLEFKHYFITSMLSYFEFENVSNPLLCEIKAELLMLKRDNWVQGVMATSGYRLMDKNYPNSDVKYKFDLLKETFVDETVFQENFLTLTKEILSLFNKCEGKRQRIVDILSIEIGLLYYQGKKYEEAVSLFLSCYEYYTQTNWNSIGLKILQVFIDSLSHCPKLDVLQIDGESVSASAVLTNAFLNILKLCKDNDSKEIWWKKFMDLQMKNNIHLMYPLDGLFEVTLNSKVHLARANVSAIEVNLKSYGFPEDISTKTMRLSLKNMGGDVIVFGASDFLLKKGENKLILECRDIMYGEFSLLSFEIIVEGITFVKEFPENQDEFIVVPEIYCKESTKVLVKQAHNLNLGEYALELKSVQSDALESLQVEVEVQKNIGNMKNLPVSFSMDEIQARKRYNTPFENVRLEYYLLDQITAFDLIIKTSFTKKNDQGTFGETKKVRIQCYLQLSVSVEDIFKKDIFFFKFLLNSSVREEPVILYSSELSAPDTRNDYNIRGDYIATTPALITFDGNESFINCYEITANNNFDSKDIFNLKVRYNTLKEQLDCFITDAVLIEGDVEWFILFEKWKTFWELEILKKLKYDYDAFKENRIIRLLKTSIDLNKTKSKIRNLCIEKAVLDKILICLNKVSRGIAVCNTDMDEYVRNLVPKQLTVPVQLPGFEQFFHVQFEQMETSHDALHDTIATIGNSLSYTVIVENLSGQWGQDVIDDGGYIFEILSSNEWLIHGQKRCAIKEKRKEFEVHLIPLKKGYLNFPRVEITNINGKSCRVDHSNAFESILIF
What is the function of this protein?
Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchange factor (GEF) for the Golgi YPT1 GTPase.  TRS130 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS120.  Required for both the cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy through its role in ATG8 and ATG9 trafficking.
What are the official names of this protein?
Trafficking protein particle complex II-specific subunit 130, TRAPP II-specific subunit 130, Transport protein particle 130 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the TMEM1 family.
What are the subcellular locations of this protein?
Golgi apparatus.