PharMolix/UniProtQA huggingface dataset:
Protein: RECR_LARHH
Sequence: MKTPASLESLITALRVLPGVGPKTAQRMAYHLMQRDPGGADRLARAIDHARSHLKHCARCNTFSETELCVLCADDQRRQDVLCVVEMPADALMIEQTHSYDGLYFVLMGKVSPLDGLTARDIPLEQLARRALDGTVNEVILATNFTAEGEATAHVLATLFKDRGLSVSRIARGLPVGGELEHVDAGTLAQALYERRRLSTGDA
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RPIA_SALEP
Sequence: MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKLKGLGIHVFDLNEVDSLGIYVDGADEINGHMQMIKGGGAALTREKIIASVAEKFICIADASKQVDILGKFPLPVEVIPMARSAVARQLVKLGGRPEYRQNVVTDNGNVILDVYGMEILDPIALENAINAIPGVVTVGLFANRGADVALIGTPDGVKTIVK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: NORM_RHOPA
Sequence: MVRAMTAPGSNIAAGALAPAKSSAWRTELIETLWLAWPMALTQLGQIAMMTTDLALIGRLGDAAVAAAALAHFVLFSTFTMGLGLVSAVTPLAAQAFGARAPRQVRASLRVGLWAGVIAGVPLTLGQLYGEELLVALGQNPATSRLAGDYLDGLAWSLVPGWLFIALRGLMGAVNRPEPALWIMLTAIPINLGLAYVLIHGSFGLPRLEIFGAGLATSIVSWAMCIAAAVVCVTMRPFRKYQVFGELFRFDGELMRRLLQLGLPISGASVLEYGVFGAAALLMGKFGTTALAAHQIALQVAAIMFMVPMGISVAATVRVGHAVGRGDPPSARRAGFAAIGLGFVFMAAMTLLVALTRHQIPQLFLGDSDTSIETATLTAALLIVGASFFIADGLQVVANGALRGRNDTKVPLLFAVLGFWVIGFPFCWVLGFHTDLGPFGVWIGLAVGLVVYAALLVWRFHRLTRDAMAAAVAA
What is the function of this protein?
Multidrug efflux pump.
What are the official names of this protein?
Probable multidrug resistance protein NorM, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AAC2_MYCTO
Sequence: MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLPIDISLDTSAELMCDWRAGDVW
What is the function of this protein?
Catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides.  It confers resistance to aminoglycosides (By similarity).
What are the official names of this protein?
Aminoglycoside 2'-N-acetyltransferase, AAC(2')-Ic.
What is the protein family that this protein belongs to?
Belongs to the AAC(2')-I acetyltransferase family.
Protein: MMUM_ECOLI
Sequence: MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS
What is the function of this protein?
Catalyzes methyl transfer from S-methylmethionine or S-adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine.
What are the official names of this protein?
Homocysteine S-methyltransferase, S-methylmethionine:homocysteine methyltransferase.
Protein: SSPI_OCEIH
Sequence: MDLNLRKAIYSNISNNDEQQLEATIVDAIQNGEEKMLPGLGVLFELIWKHSDDQEKKEMIQSLESGVKQL
What are the official names of this protein?
Small, acid-soluble spore protein I, SASP I.
What is the protein family that this protein belongs to?
Belongs to the SspI family.
What are the subcellular locations of this protein?
Spore core.
Protein: THIB_BRUSU
Sequence: MRLLSLLTFSLFAVIGLAPAAQAKDTLTIYTYDSFVSEWGPGPKVKENFEKECDCEVNFVASADGVALLNRLKLEGSKTAADIVLGLDTNLTTEARASGFFAPSGIDQTNVKVPGNFKDDIFVPYDYGYFAVVYDSEKLPNPPKSLKELVEGDPAQKIVLQDPRTATPGLGMLLWMKSVYGDEAGAAWQKLQKRVLTVTPGWSEAYGLFTKGESPMVLSYTTSPAYHMVVEKTDRYKALAYPEGNYLQIELAAQTTTGAKNPLAKKFLAFMTGPGFQDVIPETNWMFPAGKTSKPLPAAFDALPKPEKTLLIPPYEVAKNRRLWVNEWLAATSR
What is the function of this protein?
Part of the ABC transporter complex ThiBPQ involved in thiamine import.
What are the official names of this protein?
Thiamine-binding periplasmic protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MNME_CERS1
Sequence: MDTIYALASARGKAGVAVLRLSGPRSHEAVQAFGVLLPPLRHAALRRLTWNDEVLDEALVLLFGAGASFTGETSAELHLHGSPAAVSSVLRVLSGLPGLRAAEAGEFTRRALENGRLDLAQVEGLADLIDAETEAQRRQAMRVFSGAIGERAERWRADLIRAAALLEATIDFADEDVPVDVTPEVLTLIDGLLADLRREVDGSRIAERIRDGFEVAIVGAPNAGKSTLLNALARREAAITSEIAGTTRDVIEVRMDLDGLPVTFLDTAGLRDTSDLVESLGIERAVTRAKAADLRVFLLDDSGPLPGITVQADDLVVQGKADLRPGHGLRLSGRTGEGVPELVAAIGERLLGRTAGAGSLTRERHRLAIERAIGAMESVRAELLRGQQHTELAADDLRRAIRSLDSLVGRVDVESLLGEIFASFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_SODGL
Sequence: MLSNTILSRSFYKRDTLCVAKDLLGKVLKFADYYGVINEVEAYIGQDDPACHAARGYTPRTAAMFGAAGFSYVYLIYGMYHCLNIVTEREGFPAAVLIRGIDLYKPTVLSLNGPGKLCKKLNITKNNNKIDLTQSHGFCVYNTTARPEYMATPRIGIKVGTDKLWRFKSM
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: RS2_SULTO
Sequence: MSEKEKEGQLSEEEKAELQKSEKGAVIELLVPLDTYLSAGVHIGTHTCTKYMEKFVYRVRPEGLYVLDVRKIDERLRIAARFLSRFTPENILAVTSRPYAFTPVTKFAEVIRGRAIVGRFPPGILTNPQLPNHIEPEVIVATDPRTDLQAIKEASKVGIPVVAFADTDAKVDFVDFIIPANNKGRKSLALLYWVLARQILRERREIPPEGEIPQRVEDFETRLVE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: LEPA_SYNY3
Sequence: MTDVPVSRIRNFSIIAHIDHGKSTLADRLLQVTDTVQQREMKEQFLDNMDLERERGITIKLQAARMNYKAKDGQDYVLNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGVEAQTLANVYLALDNNLEIIPVLNKIDLPSAEPDRVAAEIEEVVGLDCSDIIQASAKAGIGVDDILEAIVQQVPPPADTVDQPLRALIFDSYYDAYRGVVVYFRVMDGQVKKGDKVRLMASDKEYVIDELGVLSPTQVQVEALHAGEVGYFAAAIKAVADARVGDTITMANSPAAEPLPGYTEANPMVFCGLFPIDADQYPDLKDALEKLKLNDAALSYEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYNLDLITTAPSVIYRVTTTDEEVIEVDNPSLLPPIQKRLKVEEPFIKVEMITPETYVGTLMELCQSRRGVFKDMKFFTQTRTALIYELPLAEVVTDFFDQLKSRTKGYASMEYQLIGYRENPLVKLDILVNGDGVDALAMIVHRDKAYYVGRAMVSKLKELIPRHQFKVPIQAAIGAKVIASEHIPALRKDVLAKCYGGDISRKKKLLQKQAKGKKRMKAIGTVDVPQEAFMAVLKLDPQ
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BIOF_BACC7
Sequence: MNQTWRTHLQSKLQQLHEREQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLAGDERLKEAAIACTRKYGTGATASRLVVGNYSLYEEVERSICDWKGTEKALVVNSGYTANIGVISSLVSRHDIVFSDKLNHASIVDGIILSGAEHKRYGHNDLDHLEKLLKTASPEKRKLIVTDTVFSMDGDTAYLRELVELKEKYGAILIVDEAHASGIYGIGGAGLSHIEDLAQKIDIHMGTFSKALGCYGAYLTGDAIYIEYLHNMMRSFIFTTALPPGTLGAVQKAIEIVQEDHKRRENLIANGEYFRSKLRDAGFNIGNSSTHIVPIVVGSNENALRFSKRLQEAGIAAIAIRPPTVPINSSRIRFAVTSQHTIADLKWAIDRIIHIAKEEELFV
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: SYC_SALPC
Sequence: MLKIFNTLTRQKEEFKPIHAGEVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLRFLGYKLKYVRNITDIDDKIIKRANENGESFVALVDRMIAEMHQDFDALNILRPDSEPRATHHIQEIIELTRTLIEKGHAYVADNGDVMFDVPTDPTYGQLSRQDLEQLQAGARVDVVDVKRNPMDFVLWKMSKEGEPSWPSPWGEGRPGWHIECSAMNCKQLGNHFDIHGGGSDLMFPHHENEIAQSTCAHDGEYVNYWMHSGMVMVDREKMSKSLGNFFTVRDVLKYYDAETVRYFLMSGHYRSQLNYSEENLKQARASLERLYTALRGTDKSAAPAGGEAFEARFVEAMNDDFNTPEAYSVLFDMAREVNRLKGEDMTAANAMASHLRKISGVLGLLEQEPDVFLQSGAQADDGEVAEIEALIQQRLDARKAKDWAAADAARDRLAEMGIILEDGPQGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUTC_BACC7
Sequence: MTGLIQNRESFLENIAKELGRARKTDGVKRPVWKNNVNKETLKNYSQEELLEVFKNQCTNIHTTVVETTNDRLREDIQKVIVENGGGPIMLSADERFDSYGLTSLFKEELPKQNVEVNVWDPEKKEENMRIAERANIGIAFSDYTLAESGTIVVQSHKGQGRSLHFLPTVYLAIIPRETLVPRITQAVEDMNKRVENGETVASCINFITGPSNSADIEMNLVVGVHGPLKAVYFIV
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
What are the official names of this protein?
Lactate utilization protein C.
What is the protein family that this protein belongs to?
Belongs to the LutC/YkgG family.
Protein: SURA_PSE14
Sequence: MLGALLLSGAVHAAVQPLESVVAIVDNDVIMKSQMDQRVREVQQTIAKRGSGVPPAEALQPQVLDRLILENLQLQMGERSGIRVSDNELNQAIGTIAQRNNMSVEQFRAALAHDGLSYNDAREQVRREMIISRVRQRRVAERIQVSQQEVKNFLASDQGKAQLSEEFHLANILIATPDSASSDAIQAAAVKAKGIYDQLKKGADFTRLAATTSSSENALEGGDMGWRKAAQLPPPFGDMLSAMPVGDVTPPARTPGGFIILKLLEKRGGQGQAQMRDEVHVRHILIKPSEIRNEEETKRLAEKIYDRIQNGEDFAELAKSFSEDPGSALNGGDLNWVDPNSLVPEFRQVMNETPQGELSKPFKTAYGWHVLEVLGRRSTDATDQAREQQALNVLRNRKYDEELQTWLRQIRDEAYVEIKLPGATQAAQ
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: ESR21_CARAU
Sequence: MTALNSYAFAMSEYAEGDSSLLQLQEVDSSRMGGHVLSPTFNSSSPSLPVESHPICIPSPYTDLGHDFTTLPFYSPSLLGYGTSPLSDCPSVRQSLSPTLFWPPHSHVSSLALHQQQTRLQPNHPTGGTWAELTPHDHGEEENCKPLSKRVAVAEETSTSLRGKADMHYCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGLRRDRSSYQQRGAQQNRLTRFSGRMRTSGPRSQEIKTVQRPLSGNKVVTMALSPEELIARIMDAEPPEIYLMKDVKKPFTEANVMMSLTNLADKELVHMISWAKKIPGFVEIGLFDQVHLLECCWLEVLMLGLMWRSVNHPGKLVFSPDLSLSRDEGSCVQGFAEIFDMLLAATSRFRELKLQREEYACLKAMILLNSNMCLSSAEGGEELQSRSKLLCLLDSVTDALVWAISKTGLSFQQRSTRLAHLLMLLSHIRHVSNKGMDHLHSMKMKKMVPLYDLLLEMLDAHIMHGSRLSHSGPQADPVPKESNCVQETFTCTSQHGGTLRP
What is the function of this protein?
Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
What are the official names of this protein?
Estrogen receptor beta-1, ER-beta-1, Nuclear receptor subfamily 3 group A member 2-A.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CY551_HALHA
Sequence: DGESIYINGTAPTCSSCHDRGVAGAPELNAPEDWADRPSSVDELVESTLAGKGAMPAYDGRADREDLVKAIEYMLSTL
What are the official names of this protein?
Cytochrome c-551, Cytochrome c551.
Protein: H8A16_CYRHA
Sequence: MVNMKASMFLTFAGLVLLFVVCYASESEEKEFPKEMLSSIFAVDNDFKQGERDCAGYMRECKEKLCCSGYVCSSRWKWCVLPAPWRR
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U3-theraphotoxin-Hhn1a 16, U3-TRTX-Hhn1a, Hainantoxin-VIII.16, HNTX-VIII.16, Peptide F4-27.90.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8) subfamily. Hntx-8 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FTHS_STAA8
Sequence: MTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGEGKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRIEWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKVEGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEKFMDIKAREAGFDPAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNVRIALTEVWEKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDNYPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDGHAIGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: ACP_GEOMG
Sequence: MSAIDKRVKEIVAEQLGVDEAQVTNEASFMDDLGADSLDTVELVMALEEEFDIEISDEDAEKIQSVQDAIDYITEHT
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF2_CERS5
Sequence: METEVHEAAGAAGHAGQAVGMPQLNFDYWPNQIFWLLVTLVAIYFLLTRVALPRIGAVLAERRGTITNDLAAAEELKQKAVLAEKAYNEALAKARAEAQAIIAETRAAIQAELAVATAKADAEIAAKSAESESRISEIRAGALQSVTEVAKDTAEALVAALGGKSDAASVDAAVAARMKG
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria (By similarity).
What are the official names of this protein?
ATP synthase subunit b 2, ATP synthase F(0) sector subunit b 2, ATPase subunit I 2, F-type ATPase subunit b 2, F-ATPase subunit b 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TYSY_STRP8
Sequence: MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O14K1_HUMAN
Sequence: MTNQTQMMEFLLVRFTENWVLLRLHALLFSLIYLTAVLMNLVIILLMILDHRLHMAMYFFLRHLSFLDLCLISATVPKSILNSVASTDSISFLGCVLQLFLVVLLAGSEIGILTAMSYDRYAAICCPLHCEAVMSRGLCVQLMALSWLNRGALGLLYTAGTFSLNFYGSDELHQFFCDVPALLKLTCSKEHAIISVSVAIGVCYAFSCLVCIVVSYVYIFSAVLRISQRQRQSKAFSNCVPHLIVVTVFLVTGAVAYLKPGSDAPSILDLLVSVFYSVAPPTLNPVIYCLKNKDIKSALSKVLWNVRSSGVMKR
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 14K1, Olfactory receptor 5AY1, Olfactory receptor OR1-39.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ERCC2_ARATH
Sequence: MIFKIEDVTVYFPYDNIYPEQYEYMVELKRALDAKGHCLLEMPTGTGKTIALLSLITSYRLSRPDSPIKLVYCTRTVHEMEKTLGELKLLHDYQVRHLGTQAKILALGLSSRKNLCVNTKVLAAENRDSVDAACRKRTASWVRALSTENPNVELCDFFENYEKAAENALLPPGVYTLEDLRAFGKNRGWCPYFLARHMIQFANVIVYSYQYLLDPKVAGFISKELQKESVVVFDEAHNIDNVCIEALSVSVRRVTLEGANRNLNKIRQEIDRFKATDAGRLRAEYNRLVEGLALRGDLSGGDQWLANPALPHDILKEAVPGNIRRAEHFVHVLRRLLQYLGVRLDTENVEKESPVSFVSSLNSQAGIEQKTLKFCYDRLQSLMLTLEITDTDEFLPIQTVCDFATLVGTYARGFSIIIEPYDERMPHIPDPILQLSCHDASLAIKPVFDRFQSVVITSGTLSPIDLYPRLLNFTPVVSRSFKMSMTRDCICPMVLTRGSDQLPVSTKFDMRSDPGVVRNYGKLLVEMVSIVPDGVVCFFVSYSYMDGIIATWNETGILKEIMQQKLVFIETQDVVETTLALDNYRRACDCGRGAVFFSVARGKVAEGIDFDRHYGRLVVMYGVPFQYTLSKILRARLEYLHDTFQIKEGDFLTFDALRQAAQCVGRVIRSKADYGMMIFADKRYSRHDKRSKLPGWILSHLRDAHLNLSTDMAIHIAREFLRKMAQPYDKAGTMGRKTLLTQEDLEKMAETGVQDMAY
What is the function of this protein?
ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  The ATP-dependent helicase activity of XPD is required for DNA opening.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.  XPD acts by forming a bridge between CAK and the core-TFIIH complex (By similarity).  Essential during plant growth (PubMed:12857822).  May negatively regulate a common response program mediated by UV damage and heat stress, that leads to tissue death and reduced chloroplast function (PubMed:9414549).
What are the official names of this protein?
General transcription and DNA repair factor IIH helicase subunit XPD, TFIIH subunit XPD, ERCC2 homolog, RAD3 homolog, UV hypersensitive protein 6, AtUVH6, XPD homolog, AtXPD.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD3/XPD subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PAFA_MYCSK
Sequence: MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDNLIQLVTHDRAGERVLEDLLIDAEQRLADEGIGGDIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATFCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMCESTTMLKVGTASLVLEMIEAGVPFRDFSLDNPIRAIREVSHDLTGRRPVRLAGGRQASALDIQREYYSRAVDYLQTREPNSQIEQVVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLFQRYQDRYNMELSDPKISQLDLAYHDIKRGRGVFDLLQRKGLAARITTDEEIDAAVDTPPQTTRAKLRGEFISAAQEAGRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDERVKRLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: MDCG_XANC5
Sequence: MAGRHALVWLREDAQWQAVTPGAQPRLRQWFAAGLPAVVARGDGSQAPGSVRLGVPLPPSEGKQRLALQAHVADIARCTAPLTLDAVTPQAPVAVQPLLQALLAQARAHALRPHVFGSFAWQALTGLTYVHAQSDLDLLWPIETPEQARALVTLLQRWEQQHGLRADGELLLPEDNAVNWREYAGTAQQVLVKSNQDCRLLPRAALFPVRSAA
What is the function of this protein?
Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-[acyl-carrier-protein] of the malonate decarboxylase to yield holo-[acyl-carrier-protein].
What are the official names of this protein?
Phosphoribosyl-dephospho-CoA transferase, Malonate decarboxylase holo-[acyl-carrier-protein] synthase, Holo-ACP synthase.
What is the protein family that this protein belongs to?
Belongs to the MdcG family.
Protein: SECA_LIGS1
Sequence: MANLLKRWVESDKRELKRLGKIADKVESYADEFGALSDDELKAKTEEFKKRYQDGESLDDLLPEAFAVCREGAKRVLGLYPYHVQIIGGIVLHEGNIAEMKTGEGKTLTATMPVYLNAISGKGVHVVTVNEYLSERDATEMGELYTWLGLTVGLNLADKSPEEKRNAYNCDITYSTNSELGFDYLRDNMVVYKEDMVQRPLNFVIVDEVDSILIDEARTPLIISGQATGTTTLYTRTDRFAKTLTEDEDFKIDLESKTVSLTEDGIRKGEKYFGLKNLYDPDNMALNHHLDNALRANYIMLRDKDYVVRDGEVLIVDQFTGRIMDGRRYSDGLHQAIEAKEHVEIEEETKTMANITYQNFFRMYNKLSGMTGTAKTEREEFREIYNMEVVSIPTNKPIARVDKPDLLYPTLKSKFNAVVRDVKARHEKGQPVLVGTVAVETSELLSKMLDDEGIPHSVLNAKNHAREAEIVMNAGQRGAVTIATNMAGRGTDIKLGPGVRELGGLAVIGTERHESRRIDNQLRGRSGRQGDPGVTQFYLSLEDDLMLRFGSERIKNFLERMKVSDDDAVIQSKMISRQVESAQKRVEGNNYDTRKQVLQYDDVMRAQREVIYAQRQQVIMEEKSLKPIIMPMIERTVKHTVLMHTQGDKSEWNLQGILDFAVSAMVNEDTISLGDLVNKTPDEIVDYLMKRAEDIYAEKEKQLYDESQMLEFEKVVILRVVDSLWTDHIDEMDQLRQSIGLRGYGQLNPLVEYQQDGFRMFEQMVGAIEYDVTRLFLKAEIRQDIKR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: NPC2_PIG
Sequence: MHFLAAAFLLLTLSASALAEPVHFRDCGSGVGVIKEVNVNPCPTQPCQLHKGQSYSVNVTFTSNTQSKGSKAVVHGIVMGVPIPFPIPDPDGCKSGINCPIQKDQTYSYLNKLPVKAEYPSIKLVVEWKLQDDNDQCLFCWQIPVQIES
What is the function of this protein?
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment.  Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1.  May bind and mobilize cholesterol that is associated with membranes (By similarity).  NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:10366780).  Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity).  The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
What are the official names of this protein?
NPC intracellular cholesterol transporter 2, 16 kDa secretory protein, Epididymal secretory protein E1, Niemann Pick type C2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Lysosome. Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes.