PharMolix/UniProtQA huggingface dataset:
Protein: C71B6_ARATH
Sequence: MSLFSFPISTELLPWLLLLLIPPLLIFFLLRSPKNLPPGPPRLPILGNIHQLGSLPHRSLRDLSLKYGPVITVYLGSVRTVVVHSPETAEEVLKLHDSECCTRPKLSITKSFFYDGLGLGFTKWGDYYRDVRKLCVLELFSVKRANSFRNIREEELSRLVNSFSDSASSGSSVDLTANLAKFVASFTCRMAFGLSFQGSGMDNETFLELFTEANRVIGKFAAADIFPGFGWILDRISGLDSSRRKSFQDLDTFYQKAIVDHREKKKTEDREDLIDVLLKLQSQETKLGSSRITDTHIRAIIMDLFVAGVDTSVITLDWTMAELSRHPRVMKKVQAEIREHVGDKGIVTYDDLEALVYMKMVIKETWRLHAPSPILIPREAMTNFKIKGYDIYPGTRIHVNAWAIGRNPDVWKDPDEFIPERFVDSNVETKGTSFELLPFGSGRRGCPAMYVGLSTVEYTLANLLYHFDWKATEEVSVEEAPGLTSHRKHPLHLVPVNVINRKL
What are the official names of this protein?
Cytochrome P450 71B6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GTFA_STRGN
Sequence: MTVYNINLGIGWASSGVEYAQAYRAQILRRIQQPAKFIFMDMILADNIQHLTENIGFLDEEIIWLYNYFTDIKIAPTTVTLDQVLAQVAGQPERSEKEGKIVRYFYPQDDQFITCYLRQEDQDSVEHVEYVSRGRLIRKDYFSYVRYASEYFAPHNDAATLYQRRFYHEDGSVAYDMLIEDGQEKLYRFPDRIFYSKAELVRYFLQCLQLQADDVVILDRETGIGQVVFEESQKAKLGVVVHAEHFSENASSDDYILWNNFYDYQFTNADKVDFFIVATEAQKRILEQQFQHYSDKQPQIATIPVGSLDQLTYPKEPRKPYSMITASRLATEKHIDWLVAATVQAHAQLPELTLDIYGKGSEEDKLRRRIEEAGAQDYIRLKGHADLSQIYAGYELYLTASTSEGFGLTLMEAVGSGLPLIGFDVRYGNQTFIDDGKNGYLLPVSSNHVEDQIIAAFVEKIIALFSQGRQQEMSQHSYQVAENYLTSRVEAAWTQLLKEVRDDSAL
What is the function of this protein?
Required for polymorphic O-glycosylation of GspB, a serine-rich repeat cell wall protein encoded upstream in the same operon.  Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in GspB.  Part of the accessory SecA2/SecY2 system specifically required to export GspB.  Upon coexpression in E. coli with GtfB glycosylates GspB constructs.  Glycosylation probably occurs intracellularly (PubMed:15489421).  Requires GtfB for glycosylation activity, it has no activity alone.  Does not use UDP-glucose as substrate.  Has a fast, probably processive glycosylation phase followed by a slower, non-processive phase.  The enzyme probably modifies its tertiary conformation by opening and closing its intersubunit interfaces to accomodate the increasingly glycosylated substrate; protein substrate recognition is provided by GtfB (PubMed:26884191).
What are the official names of this protein?
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase GtfA subunit, Glycosyltransferase GtfA, O-glycosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Cell membrane association requires GtfB.
Protein: PARB_CAMJE
Sequence: MGLNKDRGLSSLISDMDTVYSKELGFDKNQSTMIEIDQISPNPFQPRKNFDQEALDELANSIKEFGLIQPIIVFKKNNKFILIAGERRLRAVKALGKKEILAFIADIDENKLRELALIENIQRENLNPIELANSYKDLMQVHKITQENLAELIHKSRTQITNTLRLLNLDIRTQELIASGKISQGHAKVLVGLDQKDEKMLVDSIIGQKLNVRDTEKIVKKIKNNESLPNQEFEDEIKKLKQILNRFGFDCKNKNNDFVIHLENIDKIKKLIKMLEKL
What is the function of this protein?
Involved in chromosome partition.  Localize to both poles of the predivisional cell following completion of DNA replication.  Binds to the DNA origin of replication (By similarity).
What are the official names of this protein?
Probable chromosome-partitioning protein ParB.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
Protein: GRPE_BLOFL
Sequence: MIDNNKHNQDINASSANTIKKDELSESACKIDSIIDPKDDQIIQLQIQLAQIKEHERNTILRLKAEIENIQRRNIQEIEKAHKFALDRFVSELLPVIDNLERTLGIIDRSNTTLSAIIEGIDLTLKSFLDTVYKFGVKSIHEIHIPFNPEIHQAISTMESEKYESNQVLTIVQKGYSLNGRLVRPAMVIVAKSKS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHEU_SALSV
Sequence: MIIPWQGLAPDTLDNLIESFVLREGTDYGEHERSLEQKVADVKRQLQSGEAVLVWSELHETVNIMPKKQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: TIG_XYLFA
Sequence: MPVLIESIGNLERRLTFSVPEDRLESHVDERLREIARTARINGFRAGKVPAKVIEQRFGEKVRAEVLDSLLRETLDSAIRAHSLRLAGAARIDHANEGRLNFVATFEVVPDFGEIDVSKFSVVRRTARVTDVDIDQMIENLRLQRRTWRVAEHGAQVGHLVALETWSQAGDERLPIEGVEAGSTILGSGVMFEQIERGLEGLSKGDEKVLDVTFPDDWRVTQLAGKAVQVHVKVIEVSEPVLLEVNEEFIKSFGVKSGKLEDFRADIRANLERELKGALVSHLRREVGEQLIAAYAHVEMPPRLVEKEARLMLAKQIEQIRLSGRDPTGIPDDAHIGFMDAACKRVLVGLLVGEIAGRNRLRLDPMRVTETLHLIASTYEEPEEVFEMYRNDPKLMEGVQSLVMEEQVIEWIADRAKKTEQVLSFQEAIQQ
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: IHFA_PSEPW
Sequence: MGALTKAEMAERLYEELGLNKREAKELVELFFEEIRHALEENEQVKLSGFGNFDLRDKRQRPGRNPKTGEEIPITARRVVTFRPGQKLKARVEAYAGTKP
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: MDTL_KLEP3
Sequence: MTRFLLCSFALVLLYPSGIDMYLVGLPRIAQDLGASEAQLHIAFSVYLAGMASAMLFAGRIADRSGRKPVAIVGAVIFVVASLLCAQAHASSHFLVGRFIQGIGAGSCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKYPWQSLFYTMTGMGVMVGLLSVFILRETRPTAHPQTATPQHGGSESLLNRFFLSRILITTLSVTAILTYVNVSPVLMMEEMGFDRGTYSMAMALMAMISMAVSFSTPFALSLFTPRTLMLTSQVLFLAAGLALSLATRQTLTLIGLGMICAGFSVGFGVAMSQALGPFTLRAGVASSVLGIAQVCGSSLWIWLAAIIGLSAMNMLIGILIACSIVSLVLLLVVTPPRVAQYDEEAAVES
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y330_STRP3
Sequence: MRKSFYSWLMTQRNPKSNEPVAILADLVFDDTTFPKHTNDFELISRYLEDQASFSFNLGQFDEIWEDYLAH
What are the official names of this protein?
UPF0346 protein SpyM3_0330.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: SPED_ECO57
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPKLIDKTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDINGMKHFIDHEINSIQNFMSDDMKALYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTDSERQEITAALWKEMREIYYGRNMPAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: CAF17_PICST
Sequence: MSLPIAGLAQLSKGIIQVVGKDATKFLNGLITSRMLPNVVKKKQHTISENENRHANLSEIIDINNNWGLMHGDIYDPEENIFIGRDGLNSMFLNSKGRVTADCFLYSFPFHNSKGSFEEVLKKPNFLIEVDSRIIPEMESLLRIHKLSAKVKINTVSDIYSYYYYSDTMEFDELLEQVQDTYFRSVDPNEALVKANEFIESNLIFNSRVSSNIVGFSIDNRIPNLGIKILTNKPLNNDDQNIGVAVDDFFSESFQQSFRTNIISEDVINMRRNVNGLFEGQDADIDQTLLPFECNLDYTNGLSLDKGCYVGQELTIRTYNNGVIRKRIMPVQFFENNEETVDEISNQGYVNIDSSDKVVETLKMLNQTTLGKLDMLPLYDLPVENEESKSASPFASSPFGGESKKSRRRKASSGKIISQHDNVGFALVTLSEIERNDLFKIEVPSLEGGMRSVGIKVFTPDWWPEQEDY
What are the official names of this protein?
Putative transferase CAF17, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the GcvT family. CAF17 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MSCL_XANAC
Sequence: MGMVSEFKQFAMRGNVIDLAVGVVIGAAFGKIVTALVEKIIMPPIGWAIGNVDFSRLAWVLKPAGVDATGKEIPAVAIGYGDFINTVVQFLIIAFAIFLVVKLINRVTHRKPDAPKGPSEEVLLLREIRDALKNDTLKPPGAL
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NRDR_COXBN
Sequence: MYCPFCNAEDTKVIDSRLVEEGTQVRRRRECLKCQERFTTFETAELNLPRIIKRDGRRSAFDEEKLRAGLLKALEKRPISTEQIETAVQRIIHKLRARGECEVSSQWLGELVMDELRALDEVAYVRFASVYRSFQDINAFRDEIRRLQKQQKKSHDK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PSUG_THEAB
Sequence: MFISEKVQKALEENKPIVALESTVIAHGLPYPENLKVAQEFEDIVYENGCVPATIGILKGKVIVGLSKEQLIELVDDNPIKVGTREISYAIAMKKSAATTVSSTAKIASLAGIKVFATGGIGGVHRGEWDVSQDIIELSKTNIIVVSAGCKSILDIKKTLEFLETFQVLTVGYKTEYFPIFYNRLSKEKIYKVENADEIANIFNEKNKLKLESAILVANPIPEDYVLDNNEIEGYIKTIEKEIAEKDIHGKEVTPYMLKRLVELSNGKTLESNIVLLKNNVELACKIAQSLKK
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: PTH_MARMM
Sequence: MKILAGLGNYEPKYLRNRHNVGFMALDIIAQAWNAGPWRKRFQGLASEVTIGSNKLLLLKPQTFYNNAGNSVGAAAAFYRVKPEDIIVFHDELDLAPGKFRMKMGGGAAGNNGIKSITSQLGPDFRRARIGIGHPGDRNRVTGYVLSDFAKAEEAWLIDLLDAIAGSLDLLAAGDYDAFQTKVTHKAPAPEVVKRGPDAD
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNEE_SALTI
Sequence: MIVRPQQHWIRLIFVWHGSVLSKIFSRLLLNFLLSIAVIIMLPWYTMLGIKFTLAPFSILGVAIAIFLGFRNNACYARYVEARHLWGQLMIASRSILREVKTTLPDERGIEDFVRLQIAFAHCLRMTLRRQPQTQVLGNYLDQEALQKVVASHSPANRILLLMGEWLAIRRRSGKLSDILFHSLNNRLNDMSSVLAGCERIANTPVPFAYTLILHRTVYLFCIMLPFALVVDLHYMTPFISVLISYTFIALDALAEELEDPFGTENNDLPLDAICNAIEIDLLQMNDERDIPAKRIPDKRYQLT
What are the official names of this protein?
Voltage-dependent anion channel-forming protein YneE.
What is the protein family that this protein belongs to?
Belongs to the anion channel-forming bestrophin (TC 1.A.46) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PP4R3_TETNG
Sequence: MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERFKGTSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDVVDESEDERFDDMSSPGLELPPCELNRLEDLAELVASSLPSPLRREKLALAVENEGYIRKLLDLFHVCEDLENREGLHHIYEIIKGIFLLNRTALFEVMFSDECIMDVIGCLEFDPALPQPRRHREFLTKTAHFKEVIPISDPELRQKIHQTYRVQYIQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQDDEKFLTDLFAQLTDEATDDDKRHELVNFLKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILGMDDVQVRAAATDIFSYLVEYNPSMVREFVMQESQQNDDDILLINLIIEHMICDTDPELGGAVQLISLLRTLVDPENMLATANKTEKTEFLSFFYKHCMHVLSAPLLANTTEDKPSKDDFQTSQLLALILELLTFCVEHHTYHIKNYIINKDILRRVLVLTASKHAFLALCALRFMRRIIGLKDEFYNRYIMRNFLFEPVIKAFLNNGSRYNLMNSAIIEMFEYVRVEDVKSLTAHIVENYWKALEDVDYVQTFKGLKLRYEQQRERQDNPKLDSMRSILRNHRFRRDARTLEDEEEMWFNTDEDDLEDGETVVRTSDKIKTEEDLMEPISKFMERKKLKEPEDKEILAKSSFSGRQNPSFKLAFSGSTKTSLSSPPPSASLSPGSPGSPGSPGSGARSSPSNTSVTTKGGLVGLVDYPDDDEEEEDDDDEESKEEPLPPSKKSRLSS
What is the function of this protein?
Regulatory subunit of serine/threonine-protein phosphatase 4.
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 regulatory subunit 3, SMEK homolog 1.
What is the protein family that this protein belongs to?
Belongs to the SMEK family.
Protein: TRMFO_BACC1
Sequence: MTTQVVNVIGAGLAGSEAAYQIAKRGVQVRLYEMRPVRQTPAHHTDKFAELVCSNSLRANTLTNAVGVIKEEMRLMDSVIIRAADECSVPAGGALAVDRHEFAAKVTEYVKNHPNVTVVNEEITEIPEGPTVIATGPLTSPDLSAQLKELTGEDYFYFYDAAAPIVEKDSIDMNKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALIAAETVPLKEFEKEIFFEGCMPVEVMASRGRQTLVFGPMKPVGLEDPKTGKTPYAVVQLRQDDAAGTLYNIVGFQTHLKWGPQKEVLQLIPGLENAEIVRYGVMHRNTFINSPNLLRPTYQYKQRDDLFFAGQMTGVEGYVESAASGLLAGINAARLVKGEEPVVLPPVTAMGSMANYITATNAKNFQPMNANFGLFAPLEKKIKKKAERNEAYATRALETIRNFVNI
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2018_ROSDO
Sequence: MAGHSKWANIQHRKGRQDAVRAKLFSKLSKEITVAAKMGDPDPDKNPRLRLAVKEAKSQSMPKDNIDRAIKKSQAGDGDEYEEIRYEGYGPNGVAVIVEAMTDNRNRTASTVRSTFTKNGGNLGETGSVGFMFDRKGTVTYPADVGDADTVLMAAIEAGAEDVESSEDGHVIWCADTDLNEVATALEAELGESEQTKLVWRPTTTTELDLEGMQKLMRLIEALEDDDDVQRVTANFEASDEVMEQL
What are the official names of this protein?
Probable transcriptional regulatory protein RD1_2018.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISOA2_ARATH
Sequence: MAAWSPSVGIGSCCLNNGITRTWKFPSARLFTGRKNKIKLGSETLMFTRKRFMGDLVTSALQSYQFSKICASKTSIELREALSSRRAEADDLKKVTSYSFRTKAGALVKVKVEKKREKYSILVYVSSLELSGDDKSRLVMVWGVYRSDSSCFLPLDFENSSQDSQTHTTETTFVKSSLSELMLGLEFDGKESPFYLSFHLKLVSGRDPDGQEMLTHRDTDFCIPVGFTAGHPLPLGLSSGPDDDSWNFSFFSRSSTNVVLCLYDDSTTDKPALELDLDPYVNRTGDVWHASVDNTWDFVRYGYRCKETAHSKEDVDVEGEPIVLDPYATVVGKSVSQKYLGSLSKSPSFDWGEDVSPNIPLEKLLVYRLNVKGFTQHRSSKLPSNVAGTFSGVAEKVSHLKTLGTNAVLLEPIFSFSEQKGPYFPFHFFSPMDIYGPSNSLESAVNSMKVMVKKLHSEGIEVLLEVVFTHTADSGALRGIDDSSYYYKGRANDLDSKSYLNCNYPVVQQLVLESLRYWVTEFHVDGFCFINASSLLRGVHGEQLSRPPLVEAIAFDPLLAETKLIADCWDPLEMMPKEVRFPHWKRWAELNTRYCRNVRNFLRGRGVLSDLATRICGSGDVFTDGRGPAFSFNYISRNSGLSLVDIVSFSGPELASELSWNCGEEGATNKSAVLQRRLKQIRNFLFIQYISLGVPVLNMGDECGISTRGSPLLESRKPFDWNLLASAFGTQITQFISFMTSVRARRSDVFQRRDFLKPENIVWYANDQTTPKWEDPASKFLALEIKSESEEEETASLAEPNEPKSNDLFIGFNASDHPESVVLPSLPDGSKWRRLVDTALPFPGFFSVEGETVVAEEPLQQLVVYEMKPYSCTLFETINTTA
What is the function of this protein?
Involved in the trimming of pre-amylopectin chains.  Accelerates the crystallization of nascent amylopectin molecules during starch synthesis.  ISA1 and ISA2 work exclusively together as a multimeric holoenzyme.  ISA1-ISA2 removes preferentially branches that are very close to other branches.
What are the official names of this protein?
Isoamylase 2, chloroplastic, AtISA2, Protein DEBRANCHING ENZYME 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: PI3R4_MOUSE
Sequence: MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRARGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDRSIRDLVTQMINREPEKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGESRASGLVVLVSVITSCLQTLKSCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVQEVPRNDVNIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKTLNMENEPDNEEVDEATRPNGDYDTELQALHEMVQQKVVTLLSDPENIVKQTLMESGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALNALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVAHQISTADVYCKLMPYLDPYITQPVIQIERKLVLLSVLKEPVSRSIFDYALRSKDIASLFRHLHMRQKKRNGSLLDCPPPEDPTIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNRAKANAVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDEKRARKHVKQDSNVNEEWKSMFGSLEPPNIPQALPKTSDHEVVQPGKPPRSESSAGICVPLSTSPQVSEAAHIPSKKPVIPVVSSTVLPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHLLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGAMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRLTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLVSPERSYVVAGSTGSPSVSYYKKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDIATFQTTQGFIVTASRDGIVKVWK
What is the function of this protein?
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis.  Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).
What are the official names of this protein?
Phosphoinositide 3-kinase regulatory subunit 4, PI3-kinase regulatory subunit 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (PubMed:24089209).
Protein: YL038_MIMIV
Sequence: MVTYISFIGESQFNFYFASKKFFRLTKYFRDPINSKKFENLIKQAIIRKLPHIVNYISMIIKNNKPEFNNKLFDNLGINEYFRQCVKHNIYNAIDYFVSKDINTVNEYGKTPLITAIKSGNCIMVKKLIDYGADFNKNKIYKLAFDHRHNDIFIFLIDKKIESDKTYNKIRNNFGSICNTNINELVESK
What are the official names of this protein?
Putative ankyrin repeat protein L38.
Protein: RL2_BURCM
Sequence: MAIVKVKPTSPGRRAMVKVVNKNLHQGKPFAALLDSQSSTAGRNNNGRITTRHKGGGHKQHYRIVDFRRTKDGIPAKVERLEYDPNRSANIALVLYADGERRYIIAPKGLTVGQQLMSGSEAPIRAGNTLPIRNIPVGTTIHCIEMLPGKGAQMARSAGTSAMLLAREGVYAQVRLRSGEIRRVHIECRATIGEVGNEEHSLRQIGKAGANRWRGIRPTVRGVAMNPVDHPHGGGEGKTAAGRDPVSPWGTPAKGYRTRSNKRTTTMIVQRRHKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ASAH2_DANRE
Sequence: MASKSRRLSGLEISLIVLFLLMTAVSVALITVLALKQESDKKEEVTPEEPSPSVTPPEKPYLIGVGRADCTGPVADLPMMGYANTDQTARGLHTRLFSRAFIVDDGNKRVVFVTSDIGMVSQRLRLEVFQALKEKYGDLYRQDNVVLSGTHTHSGVGGYFQYTLFMITSKGYIKPSIQAIVSGIVKSIDIAHRNLRPGRIFINKGQVADSNFNRSPHSYMNNPEEERNRYEFNTDKQIVVLKFTDLDGDGIGLLSWFAVHPVSMNYTNRMVSSDNLGYASYIFEQEKNIGFLPGEKGPFVAGFSSSNLGDSSPNIRGPVCVNTGLKCDYINSSCPVGGKKACIAFGPGEDMFESTRIIGENMFKIAKELYGSAKQELHGPVYGAHQWVNMTDETVQFNSTHTGRTCKPALGHSFAAGTTDGGGEFNFLQGDTEGDPFWDGIRDAVLGPPSNETKACHQPKPILFSTGEMDSPLPWHPAIVDVQIITIGSLAVVAVPGEFTTMSGRRIREAVKRELEVKEPFTNAEVVVAGLCNIYTHYITTYEEYQIQRYEGASTIFGPHTLSAYIQRYRGLAKAIAHGTIGELPKGPEPPFFDEDKLFNQVRDPVADVAPVGTTFGDVLQEVNPVYKVGEIASVTFVSGNPRHSGDIRDTTLVTVERFHNDTGSWEIIHNDASWETRFHWIKGLAGRSQAKVEWHIPQTAQAGTYQIQYFGHYKQTTENTTVITPYVGTSAAFKVARSFYYF
What is the function of this protein?
Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:15271994).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation.  Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine.  Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (By similarity).  Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity).
What are the official names of this protein?
Neutral ceramidase, N-CDase, NCDase, Acylsphingosine deacylase 2, N-acylsphingosine amidohydrolase 2, znCD.
What is the protein family that this protein belongs to?
Belongs to the neutral ceramidase family.
What are the subcellular locations of this protein?
[Neutral ceramidase]: Cell membrane; Single-pass type II membrane protein. Membrane raft; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Mitochondrion. Secreted, extracellular exosome.
Protein: RL35_LISW6
Sequence: MPKMKTHRGSAKRFKRTGSGKLKRRHGFTSHMFANKSQKQKRKLRKSAMVSAGDFKRIRQMVAKMK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RBSA1_RUBXD
Sequence: MRPLLEMRGITKRFPGVVALDGVDFELLPGEVHVLLGENGAGKSTLIKILSGAYRPDGGEILMDGRPVEIRSAAEARRLGISTIYQEFNLVPQLTVAENIHLGRQPRRFGVVDRGAMERAARELLERLGIRVDPRARVADLGVARRQMVEIAKALGLRARVLIMDEPTAALSEREVRQLFRIVRRLKEEGVGVVFISHHLEEVAEIGERVTVLRDGRLVGRVSADAGRDELVRMMVGRSIEEQFPRRRTEPGEVLLEVRGLGRRGVLRDVSLRVRAGEIVGVAGLVGAGRTELARAIFGLDPADSGEVLVEGRPLEAPGPQEARRRGVGFVTEDRQGQGIVPPLSVAENLALASLERYLRGRVLVDRGRLLRRAREIVQSLRIRTPSLEQEIRYLSGGNQQKAVIGRWMLAGSRVLIMDEPTRGVDVGAKVEIYELMNRLTEEGAGILMISSEMPEVLGMSDRVLVMSGGRITGELPAEEATQERVMGLATAGSEAAVG
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.