PharMolix/UniProtQA huggingface dataset:
Protein: MRAY_DESRM
Sequence: MDYTVVWLAAGISFLVTLVLGPVTIPLLQRLKFGQTIRAEGPAAHMAKTGTPTMGGIMFLIGIAVAGAVLLVSNIPGRAEGLVVLAVTLGYGLIGFLDDFIKVVLKRNLGLKAREKILGQLVFATVLAVVAVFKLGRGTDYIIPFSSGISFDLGWWPFFFLTLFVLLGTSNGVNLTDGLDGLASGATVFTATAFAILALVTGKIGLAIVLAAVVGGCLGFLFYNRHPAKVFMGDTGSLALGGALGAGAVVTRNELLLVVIGGLYVLETLSVIIQVISFKTTGRRVFRMSPLHHHFELSGWSERKVVRNFWLLSFLFSLVGLLGAQDFWLWLSNR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PUR9_ECOL5
Sequence: MQQRRPVRRALLSVSDKAGIVEFAQALSARGVELLSTGGTARLLAEKGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDAIMEEHQIQPIDMVVVNLYPFAQTVAREGCSLEDAVENIDIGGPTMVRSAAKNHRDVAIVVKSSDYDAIIKEMDANEGSLTLATRFNLAIKAFEHTAAYDSMIANYFGSMVPAYHGESKEAAGRFPRTLNLNFIKKQDMRYGENSHQQAAFYIEENVKEASVATATQVQGKALSYNNIADTDAALECVKEFAEPACVIVKHANPCGVAVSNSILDAYDRAYKTDPTSAFGGIIAFNRELDAETAQAIISRQFVEVIIAPSASEEALKITAAKQNVRVLICGQWGERAPGLDFKRVNGGLLVQDRDLGMVGAEELRVVTKRQPTEQELRDALFCWKVAKFVKSNAIVYAKNNMTIGIGAGQMSRVYSAKIAGIKAADEGLEVKGSSMASDAFFPFRDGIDAAAAAGVTCVIQPGGSIRDDEVIAAADEHGIAMLFTDMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: MP2K1_RAT
Sequence: MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation.  RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2.  Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade.  Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).  Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements.  One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis.  MAP2K1/MEK1 has been shown to export PPARG from the nucleus.  The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Nucleus. Membrane; Peripheral membrane protein. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis. Membrane localization is probably regulated by its interaction with KSR1.
Protein: ATPA_STIHE
Sequence: MKMRPEEISSIIMKQIEQYNQEVQVVNFGTVFQVGDGIARIYGLEKVMAGELLEFEDGTIGIALNLEAKNVGAVLMGDGLKIKEGSKVRATGKVAQIAVGEGYLGRVVDSLARPIDGKGDIASDDTRLIESPAPGIISRRSVHEPLQTGLIAVDAMIPIGRGQRELIIGDRQTGKTAIAIDTILNQKGKNVICVYVAIGQKASSVAQVVNTLRERGALDYTVIVTANADSAATLQYLAPYTGATIAEYFMYTNRHTLVIYDDLSKQAQAYREMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDALGSGSMTALPIVETQEGDVSAYIPTNVISITDGQIFLSADIFNSGVRPAINVGISVSRVGSAAQPKAMKQVAGSLKLQLAQFEELRAFSQFASDLDQATQNQLARGARLVEILKQAQNSPLGLAEQVASIYAGNNGYFDNLQVLQVRPFLIGLRQLLATKYSKYGEIVASAQTLTPEAETILKQAITEYLDEFGAKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: SECA_DESVM
Sequence: MFDTLFKSIFGSSNDRYIKRCRTRVEAINALEPQMQALADEDFPARIAEYREQAQNGRSLDDLLPEVFALTREAGKRALNMRHFDVQLVGGMVLHEGRIAEMKTGEGKTLVATLPVVLNAISGLGVHVVTVNDYLAKRDAAWMGRLYNFLGLSVGVIVHGLSDEERKEAYGADITYGTNNEFGFDYLRDNMKFYPHQLVQREHNFAIVDEVDSILIDEARTPLIISGPSEDSTGLYRRVDDIIPKLSPEAHFSVDEKARTATLTDEGVAKCEELLGIDNLFDPGNITFQHHVLQALKAHHVFRRDVDYIVTPEDQVVIVDEFTGRLMPGRRFSDGLHQALEAKEKVKVEAENQTLASITFQNYFRMYKKLAGMTGTADTEAVEFQQIYGLQVITIPTNKPMVRKDYPDSIYRTRREKFEAIVAAIGELHKSGQPVLVGTISIETSELLSAMLKKTGVPHNVLNAKHHEQEAEIVAQAGQRGKVTIATNMAGRGTDIVLGEGVRESGGLHILGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSLEDDLMRLFGSDRISGLMQKLGMEEGEPIENRMVSRAIENAQKRVEGHNFEIRKTLLDYDNVMNQQREVIYTLRRETMMEADLEETAVEFMDDLFDEIYGDAEQGKGSEGDDAKAYAMARLRDVFNITRVLPLTDGQLPDRETARGAVLSILDELKRDTGEVYRDILRFFLLEEVDRCWKEHLLNMDHLRDGIGLRGYGQRDPKQEYKREGFSLFQEMLFRVRENLFRALTRLRIQREEQAPPEELKQEFKHKEEPKSLNYSGAQKETPSAAPERRGEPKVGRNDPCPCGSGQKYKKCCGA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: RNPH_DINSH
Sequence: MRPSGRQTHEMRGVSIETGFTRHAEGSCLISMGETRVLCTASVEERVPPFLRNTGLGWVTAEYGMLPRATHTRGRREAAAGKQSGRTQEIQRLIGRSLRAGVDRVALGERQITIDCDVIQADGGTRCASITGAWVALRLAVNKLMKAGDIITDPLTDHVAAVSCGLYAGQPVLDLDYAEDSEAGTDANFVMTGSGGLIEVQGSAEGAPFSRNALNTLMDLAEVGVAELVAAQKAATS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: SAM12_MOUSE
Sequence: MAVEALHCGLNPRGIDHSAHADGIKLQIEGEGVESQSIKNRTFQKVPDQKGTPKRLQGEAETAKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQLYSESFKQHDITGRALLRLTDKKLERMGIAQENQRQHILQQVLQLKVREEVRNLQLLTQASVECSP
What are the official names of this protein?
Sterile alpha motif domain-containing protein 12, SAM domain-containing protein 12.
Protein: LNSA_STRCL
Sequence: MQEFEFAVPAPSRVSPDLARARARHLDWVHAMDLVRGEEARRRYEFSCVADIGAYGYPHATGADLDLCVDVLGWTFLFDDQFDAGDGRERDALAVCAELTDLLWKGTAATAASPPIVVAFSDCWERMRAGMSDAWRRRTVHEWVDYLAGWPTKLADRAHGAVLDPAAHLRARHRTICCRPLFALAERVGGYEVPRRAWHSSRLDGMRFTTSDAVIGMNELHSFEKDRAQGHANLVLSLVHHGGLTGPEAVTRVCDLVQGSIESFLRLRSGLPELGRALGVEGAVLDRYADALSAFCRGYHDWGRGASRYTTRDHPGDLGLENLVARSSG
What is the function of this protein?
In vitro, catalyzes the formation of R-linalool from geranyl diphosphate (GPP).  Can also accept farnesyl diphosphate (FPP) as substrate to produce trans-nerolidol.
What are the official names of this protein?
R-linalool synthase, bLinS, Monoterpene synthase, Sesquiterpene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: YR760_MIMIV
Sequence: MDCFSQNEVFFMVTNTDEDIIIESSQKFFFTRIDNVFDFLKYGIYLREITLPTNNTNFKLYTENGKLSANIINFDVKHKLSDPETFDYLVEKGANIKPHLVNILFWASNHGFLNIIKYVHKYGIDLRTNNDYALRLACKGGHNNVVKFFIRNGLDPKASNDFAICWAAEFGHYETVKILIKYNLDITTCSNYALRYACKNGYITLANYLIENGADISAGDNYCIKIASEKGHYYMVNYLISKGADVTAGNNYALNFAIKKDYIFIAKLLMKYGADIKEYLNDNLIDACRRNSIVTVRFLAENGANINNSVVITTIVQHNYLDMLKCLVDTGLNLNSKKHDILSIARDKGRTTIIEYMMSQNIDVLRWGITNGYLDFVKMIPVIDNGFGIELALILGHLDIAKYLISQNSNYQVDYDYVFRWSCRNGLTVIVKFLLSMKMEPQSISYAVEWATENGHLDILKIILNKYMNVKIGKSIQTAREKNYPEILDFLIGYLVKQEVD
What are the official names of this protein?
Putative ankyrin repeat protein R760.
Protein: CD22_GORGO
Sequence: MHLLGPWLLLLVLEYLAFCDSSKWAFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKKKNCTLSIHPVHVNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPMYTTVSWLKDGTSLKKQNTLTLNLSEVTKDQSGKYYCQVSNDVGPERSAEVFLQVQYAPEPSTVQILHSPAVEGSEVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPTPIREGDTVTLSCNYNSSNPSVTRYEWKAHGTWEEPSLGVLKIQNIGWDNTTIACAACNNWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLNVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPETNIPRTGDAETSEMQSPPPDCDDTVTYSVLHKRQMGDYENVIPDFSEDEGIHYSELIQFGVGERPQAQENVDYVILKH
What is the function of this protein?
Mediates B-cell B-cell interactions.  May be involved in the localization of B-cells in lymphoid tissues.  Binds sialylated glycoproteins; one of which is CD45.  Preferentially binds to alpha-2,6-linked sialic acid (By similarity).  Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling.  Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules.
What are the official names of this protein?
B-cell receptor CD22, Sialic acid-binding Ig-like lectin 2, Siglec-2.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NUP1_PENCI
Sequence: WGALGHATVAYVAQHYVSPEAASWAQGILGSSSSSYLASIASWADEYRLTSAGKWSASLHFIDAEDNPPTNCNVDYERDCGSSGCSISAIANYTQRVSDSSLSSENHAEALRFLVHFIGDMTQPLHDEAYAVGGNKINVTFDGYHDNLHSDWDTYMPQKLIGGHALSDAESWAKTLVQNIESGNYTAQAIGWIKGDNISEPITTATRWASDANALVCTVVMPHGAAALQTGDLYPTYYDSVIDTIELQIAKGGYRLANWINEIHGSEIAK
What is the function of this protein?
Hydrolyzes only single-stranded DNA and RNA without apparent specificity for bases.
What are the official names of this protein?
Nuclease P1, Deoxyribonuclease P1, Endonuclease P1.
What is the protein family that this protein belongs to?
Belongs to the nuclease type I family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEPA_RUMCH
Sequence: MPSERQKYIRNFCIIAHIDHGKSTLADRLLEKTGVLTSREMQEQVLDNMELERERGITIKAQAVRMVYKASDGHEYIYNLIDTPGHVDFNYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALEHNLEIMPVINKIDLPSAQPEVVKKEIEDVIGLDASQAPMISAKNGLNIEEVLEKIVDMIPCPEADEKAPLRALIFDSFYDSYKGVIVYIRVKEGTLKTGDTIRLMYTKKEFLVTELGYLKPGGLSPADELKAGDVGYIAASIKNVRDTRVGDTITLVENPAKEPLPGYKKVNSMVFCGIYPADGSKYGDLRDALDRLQLNDAALTFEPESSVALGFGFRCGFLGLLHMEIIQERLEREYNFDLVTTAPSVIYRVTTTDGDVIEIDNPTNLPPVTEIDSMEEPMVKATIMVPTEYVGNIMDLSQERRGIYKDMSYIDEGRAMLTYEMPLNEIIYDFFDALKSRTKGYASFDYELVGYKESDLVKLDIMLNGEIVDALSFIVHREKSVARGRRMAEKLKESIPRQMFEIPIQACIGGKIIARETVKAFRKDVLSKCYGGDISRKRKLLEKQKEGKKRMRQVGSVEVPQEAFMSVLKLD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BRCC3_MOUSE
Sequence: MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDIRSDSKFTYTGTEMRTVQEKMDTIRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHITIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEKEELMEELSSLE
What is the function of this protein?
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:23246432, PubMed:34180153).  Does not have activity toward 'Lys-48'-linked polyubiquitin chains (By similarity).  Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) (By similarity).  In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (By similarity).  Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (By similarity).  Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (By similarity).  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (By similarity).  Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (By similarity).  Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (PubMed:23246432, PubMed:28943315).  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (By similarity).  Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (PubMed:34180153).
What are the official names of this protein?
Lys-63-specific deubiquitinase BRCC36, BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRISC complex subunit BRCC36.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. BRCC36 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm.
Protein: UBP19_RAT
Sequence: MSAGTSATGPRRGPPGLEEATSKKKQKDRANQESKDGDPRRVSMPRKEPTKDELLLDWRQSSDKVVVKLRVGTGPICLEEVDAAFTDTDCVVRLPDGRQWGGVFFAKIQSSCTKVQTRKGGLLQLALPKKVPLLTWPSLLKKPLGTQELVPGLRCQENGQELSPIALEPGSEPRRAKQEARNQKRAQGRGEVGSGASPGAQAGPSAKRAVHLCRGPEGEGSMDGPGPQGDAPSFLSDSATQVEAEEQLHVPPVNPQTSLLGSEKNLALLTVEKTVSPRSDSVSPVMIRNRDPEKDDHFKEEMAVGADPAALADEPESMVNLAFVKNDSYEKGPDSVVVHVYVKESRRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTIFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPATRVGGAKVAVPTGPTPLDSTPPGGGPLPLTGQEEARAVEKEKPKARSEDSGLDGVVARTPLEHVTPKPEPHLASPKPTCMVPPMPHSPVSGDSVEEDEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPIYYFAREPHSKPIKFLVSVSKENSSASEVLESLSQSVHVKPESLRLAEVIKNRFHRVFLPSHSLDAVSPTDVLLCFELLSPELAKERVVVLEVQQRPQVPSIPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQFCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTSSLEAGDSEREPIQPSELQLVTPVAEGDTGAHRMWPPADRGPVPSTSGISSEMLASGPMEGCSLLAGERVSRPEAAVPGYQHSRESVSAHTPQFFIYKIDASSREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPSDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAAHAEHHPDLGPAAEAAASQASRIWQELEAEEEMVPEGPGPLGPWGPQDWVGPPPRGPTTSDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR
What is the function of this protein?
Deubiquitinating enzyme that regulates the degradation of various proteins.  Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation.  Involved in decreased protein synthesis in atrophying skeletal muscle.  Modulates transcription of major myofibrillar proteins.  Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates.  Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination.  Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner.  Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis.  Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.  Exhibits a preference towards 'Lys-63'-linked ubiquitin chains (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 19, Deubiquitinating enzyme 19, Ubiquitin thioesterase 19, Ubiquitin-specific-processing protease 19.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RECF_MARMS
Sequence: MPLVRLDISHVRNLSSVRFEPSPQVNVIVGKNGSGKTSVLEAIHLLSFGRSFRSHKHKTYIQHENDACIVFAQLHQKQGSPIRVGLQRHRDGQIDVRIQGQRAQSVIELAERLPVQLINPDAFRLLEGSPSIRRQFIDWGAFHFDKDFIQAWRGWQKALKQRNTLLRRGKISLSLLAAFDQELIRLGEQVNQSRKAYVEKLTPHFVKVLSLLTTELSVSLQFFQGWDAQKNLAMAVEAGRERDIELGYTHTGPQRADLRVKTATGDALDTLSRGQQKLVVSALKIAQGQLLIDMGRPLVFLVDDLPAELDANHRQKLCQLLESLNSQIFITSVEPDTTDFTWADTTDVRQFSMTNGELSLLSKGLQES
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_SHEHH
Sequence: MSITKDQILEALAAMSVMEVVELIEAMEEKFGVSAAAAVVSGGGEAAAAEEKTEFDVILTSHGANKVAVIKALRGATGLGLKEAKTMAESSPIAVKEAISKEEADALKADLEAAGAEVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: Y1272_IGNH4
Sequence: MKKVLPVPKEFKPGDRFVAVGTLPLCEGCMLKERCEEYKRGWIYEVKGKVGLVEHDCKVHGKVVMGEVEEVGIPLILPKRLAIEGATVEYTPSKCTNKKCPHWRDCTAPWGERVKVKVREVLEEVQCPLGLPLVRVIGVPVEVKRRTRRNIKKGKGGHGKRGLAP
What are the official names of this protein?
UPF0179 protein Igni_1272.
What is the protein family that this protein belongs to?
Belongs to the UPF0179 family.
Protein: RBR_CAMSI
Sequence: MEDHPPKPSIPTADASLSNHGRGGPSLDARFAYFCKTGLSLNENTYTEAMKLFSESKHLLSTTISAIGTGTPEEAERYWFAFVLYSVKRLSEANADDSSQGTGGDGFTLCQILRVAKLNIVDFFKELPQFIVKAGPILSNQYGTDWEKRLEAKELQANFVHLSLLSKYYKRAFREFFLTSDAKVGEQSTAAIASGYVSDYHRFGWLLFLALRTHAFSRFKDLVTCTNGLVAILAILIIHIPVRVRNFNLHDSPRFVMKGSKGVDLLASLCNIYETSEDELRKTMEKANDLIEDILKKNRRSASECRSENLENIATDGLIYFEDLLDDTSLPSSLNILGKDYADATRNKGELDERVFVNEEDSLLGPGSLSGGAMNISGAKRKIDSIASPARTITSPLAPYCSPSASHAKAIPCGSNSKMAATPVTTAMTTAKWLRTIISPLPPKPSPELERFLSSCDSDVTTDVIRRANIILEAIFPSSGLGEECITGGLQCTSLMDSIWAEQRRLEALKLYYRVLQAMCTAEAQILHANNLTSLLTNERFHRCMLACSAELVLATHKTATMLFPAVLERTGITAFDLSKMIGVSFRLKESLPRELKRHLNSLEERLLESMVWEKGSSMYNSLTVARPALSAETNRLCLLAEPMPSLDAIAMHMNITCGSLPCLPSLQKNEILLGQNGDIQSPKRLCTEYRSVLVERNSFTSPVKDRLLTFNTPKSKLPPPALQSAFASPTRPNPGAGGETCAETAINVFFSKIVKLGAFRINGMVERLQLSQEIREIIFRLFQQILSQRTTLFFNRHIDQIILCCFYGVAKISQLSLTFKEIISTIESNPQCKPQVFRSVFVDWSSARRHGKTGQEHVDIITFYNEIFIPAVKPLLVELAPVGTAQKNRNSETINGTDGQCPGSPKISPFPSLPDMSPKKVSAIHNVYVSPLRSSKMDALISNGSKSYYACVGESTHAYQSLSKDLTAINNRLNGNRKLRGTLNFDEVDVGLVSDTLVANSLWLQNGSCASSSGAPVKSERLDS
What is the function of this protein?
Regulator of biological processes that recruits a histone deacetylase to control gene transcription.  May play a role in the entry into mitosis, negatively regulating the cell proliferation.  Formation of stable complexes with geminiviridae replication-associated proteins may create a cellular environment which favors viral DNA replication (By similarity).
What are the official names of this protein?
Retinoblastoma-related protein.
What is the protein family that this protein belongs to?
Belongs to the retinoblastoma protein (RB) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CRCB_BACFR
Sequence: MKEIIYIFIGGGMGSVTRYLTQIAVNERLSPALFPFPWGTFAVNIIGSLLIGFFYSFSERFNLSFELRLFLTVGFCGGFTTFSTLANDSLSLLKGGFYGIFTFYVFISILLGLLAVLAGGYLGEQFK
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.