PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_XANOM
Sequence: MEQGVIERARELRRRIENADHRYYDLADPEITDAQYDQLFRELQELEQKYPELVTADSPSMRVGGAVRKSFVKVRHSIPMLSLANAFDEVEVKNFVDRIFRRMGSSNPLEFSVEPKFDGLAISLRYELGKFVQGVTRGDGDVGEDVSENIRTIRSVPLKLKGNNVPAILEVRGEVYMPRDGFSEFNKRAMARGEKLLANPRNGAAGSLRQLDSRISAQRPLSFFAYGVGLIQVEQDLFEEIPQSIASTHSAMLAQLRAWGFPVSSLVEVVQGSDGLLAYYQRIGEARDGLPFDIDGVVYKLDDLAGQREMGFVSRAPRWALAHKFPAQEQSTTVEAIEIQIGRTGAATPVARLKPVHVAGVIVTNATLHNADQIARLDVRVGDTVIVRRAGDVIPEVAAVVADQRPPATQSWQMPTQCPVCGSEIVREEGQAVWRCSGELTCPAQRKEAFRHFVSRRAMDVDGLGEKFIEVLVDSGVVQGVADLYLLTVDQLLQLRMISTAESPHAFLREAREHLASGAYAQLEATLVGIGVDLAGEREVPQTWQADLLRAGLPTFDWNRKKIATKWAENLIEAIETSRDTTLERFLFALGIEHVGESTAKALSAWFGDLDLIRHLPWPLFKRVPDIGGEVARSLGHFFDQPGNQKAIDHLLARKVRIGDTHPPSPKLRGELRLANLLEDLEIPKVTPIRAAQIATAFGSIDALRNGGPEPLVEAGVPQSVAESLATWLLVPANDTLAVNAQKKLSALLAMMPEAGEEKTGPLDGQTVVITGTLAALTRDAAKQRLEALGAKVAGSVSKKTAFLVAGEEAGSKLDKAQSLGVEIWDEARLLAFLGEHGQQR
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ILME_SEPOF
Sequence: ILME
What is the function of this protein?
Has myotropic activity targeting the genital tract.
What are the official names of this protein?
Pheromone peptide ILME.
What are the subcellular locations of this protein?
Secreted.
Protein: RL28_BRUAB
Sequence: MSRACELTGKSVQYGNNVSHANNRTRRRFLPNLCNVTLISETLGQSYRLRISANALRSVEHRGGLDAFLVKSDDKELSQRARLLKRQIAKKQAEAAA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: MUTS_THECA
Sequence: MPAVKMGVMLKGEGPGPLPPLLQQYVELRDRYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPIRAFDAYAERLLRMGFGLAVADQVEPAEEAEGLVRREVTQLLTPGTLTQEALLPREANYLAAIATGDGWGLAFLDVSTGEFKATLLKSKSALYDELFRHRPAEVLLAPELRENEAFVAQFRKRFPVMLSEAPFDPEGEAPLALSRARGALLAYARATQGGALSVRPFRLYDPGAIVRLPEASLKALEVFEPLRGQDTLFGVLDETRTAPGRRLLQAWLRHPLLERGPLEARLDRVERFVREGALREGVRRLLFRLADLERLATRLELSRASPRDLAALRRRSLEILPELEGLLGEEVGLPDLSGLLEELRAALVEDPPLKVSEGGVIREGYDPDLDALRRAHADPVAYFLDLEVREKESTGIPTLKVGYNAVFGYYLEVTRPYYEKVPQEYRPVQTLKDRQRYTLPEMKERERELYRLEALIKRREEEVFIALRERARKEGEALREAARILAELDVYAALAEVAVRHGYTRPRFGERLRIRAGRHPVVRRRTAFVPNDLEMAHELVRVTGPNMAGKSTFLRQTALIALLAQIGSFVPAEEAELPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALVLKEATERSLVLLDEVGRGTSSLDGVAIATALAEALHERRCYTLFATHYFELTALALPRLKNLHVAAKEEEGGLVFYHQVLPGPASKSYGVEVAEMAGLPKEVVERARALLSAMAARREGALEEVLERLLALDPDRLTPLEALRFLHELKALALGLPLGSMKG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: NAR1_PICST
Sequence: MSAILSADDLNDFISPGVACIKPPAQNSDQKFNSLNENGEVEIQIDSEGNPLEISKIDGKQTNLSPAQISLADCLACSGCITSAEEVLVAQHSHEELIKALNEKVDNNSTKVFVASISHQSRASLATAYNLSIEEIDKLLINLFINQMGFKYIVGTSIGRKLSLINEAQNLIEKKESEFDGPVLSSICPGWVLYAEKTHPYVLPRMSTVKSPQQITGCLLKTLAAHELGVTRNDIYHLSIMPCFDKKLESARPEKYGEQNTSNDVDCVLTAKELVTLLEQHSDKFQLIPPQAHTITNSAIPVVDLYSKCAPRTWPLVQYSWSNDSGSASGGYGYNYLKMYQNHLIMKHPTKYQQEGFSIDYVKGRNTDLTEMRLMYGSEKLASSAIVNGFRNIQNLVRKLKPTVKPGSTTGKGNALVARRRARVAGGITKASSPAGSDESADASKCDYVEIMACPNGCINGGGQINPPEDVSEKDWLSASLEKYNSIPLLDLAAMENVDTVAEIMQWSCLFREEFGVSENRLLKTWFNEVEKPTDSASILLGARW
What is the function of this protein?
Component of the cytosolic Fe/S protein assembly machinery.  Required for maturation of extramitochondrial Fe/S proteins.  May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NAR1, Nuclear architecture-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
Protein: TOM6_YEAST
Sequence: MDGMFAMPGAAAGAASPQQPKSRFQAFKESPLYTIALNGAFFVAGVAFIQSPLMDMLAPQL
What is the function of this protein?
Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.  TOM6 is involved in assembly and stability of the TOM complex.
What are the official names of this protein?
Mitochondrial import receptor subunit TOM6, Mitochondrial import site protein ISP6, Translocase of outer membrane 6 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the Tom6 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: PBGP9_SOLSB
Sequence: MKTFVLHIFIFALVAFASASRDSAKKIGSQYDNYATCLAEHSLTEDDIFSIGEVSSGQHKTNHEDTELHKNGCVMQCLLEKDGLMSGADYDEEKIREDYIKETGAQPGDQRIEALNACMQETKDMEDKCDKSLLLVACVLAAEAVLADSNEGA
What is the function of this protein?
Colony queen number, a major feature of social organization, is associated with worker genotype for Gp-9.  Colonies are headed by either a single reproductive queen (monogyne form) or multiple queens (polygyne form).  Differences in worker Gp-9 genotypes between social forms may cause differences in workers' abilities to recognize queens and regulate their numbers (By similarity).
What are the official names of this protein?
Pheromone-binding protein Gp-9, PBP, Putative odorant-binding protein Gp-9.
What is the protein family that this protein belongs to?
Belongs to the PBP/GOBP family.
What are the subcellular locations of this protein?
Secreted.
Protein: NRAM_I57A2
Sequence: MNPNQKIITIGSVSLTIATVCSLMQIAILATTVTLHFKQHECDSPASNQVMPCEPIIIERNITEIVYLNNTTIEKEICPEVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNGTIHDRIPHRTLLMNELGVPFHLGTKQVCVAWSSSSCHDGKAWLHVCVTGDDRNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIKEGKIVHISPLSGSAQHIEECSCYPRYPDVRCICRDNWKGSNRPVIDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRDPNNERGNPGVKGWAFDNGDDVWMGRTISKDSRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: NUOK_PSEFS
Sequence: MPAIPLEHGLAVAGILFCLGLVGLMVRRNILFVLMSLEIMMNAAALAFIVAGARWGQPDGQVMFILVISLAAAEASIGLAILLQLYRRFHTLDIDAASEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL27_XANC8
Sequence: MAHKKGVGSSRNGRDSNPKYLGVKIFGGQAIDAGNIIVRQRGTQFHPGAGVGLGRDHTLFALVNGKVEFTTKGPKKRRTVSVVAEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: HYPA_NITSB
Sequence: MHEYSIVQSMLDLIEENAKKHNAMKVEKVVVKIGVMSGVEAHLLKIAFDTFKEGTLCSDAELEMIIQPIIAKCRACKKESRFEKNEIFYECKHCGDVDLEIVDGEDMILMQLDMN
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: O10A4_HUMAN
Sequence: MMWENWTIVSEFVLVSFSALSTELQALLFLLFLTIYLVTLMGNVLIILVTIADSALQSPMYFFLRNLSFLEIGFNLVIVPKMLGTLIIQDTTISFLGCATQMYFFFFFGAAECCLLATMAYDRYVAICDPLHYPVIMGHISCAQLAAASWFSGFSVATVQTTWIFSFPFCGPNRVNHFFCDSPPVIALVCADTSVFELEALTATVLFILFPFLLILGSYVRILSTIFRMPSAEGKHQAFSTCSAHLLVVSLFYSTAILTYFRPQSSASSESKKLLSLSSTVVTPMLNPIIYSSRNKEVKAALKRLIHRTLGSQKL
What is the function of this protein?
Odorant receptor (Potential).  May be involved in taste perception.
What are the official names of this protein?
Olfactory receptor 10A4, HP2, Olfactory receptor-like protein JCG5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PUL3_KLULA
Sequence: MKLTDSQKHLYSQYLAVTLIAVQFSFDTCVYLSSVVQYVKECGSDDPENYLFILQAVSAAVQVFFSFIIGDIASYVGSIKWVIIFLYFLSFVGNFLYSCAGAVSLNTLLGGRIICGAASSSGAVVYSYITAISKDRTTIFKLFSIYRTSAGICMALAQLVAILFALCDFTVRGYRITSYNAPTFASSFIILLICVLLMFVLENPPVKSARNPKNYLDAWKKFFSAGSNRLIASLILLWNMFLSTFFMCEVLYFMPIFLTLNVGWKTEYEGVAFMVSAVLGVAGSFFAPDLVKLFAKLNTPSTQDETDTSDNDKIEKEESEQKSDINTLHRNQVSLTIFALFVALIGQAFMIGASEALSNDKLPKTNSGIFFTAGLSITMLGYNFMGSSVPALFSMYIDPQVKVQLMPFIGAIAGVGKLVAPIVLAALYKTPLGLPIGVGFGMILVGISIPSLVYLRRNKM
What is the function of this protein?
MFS-type transporer required for the uptake of iron via the uptake of the siderophore pulcherrimin-iron complex.
What are the official names of this protein?
MFS-type transporter PUL3, Pulcherrimin biosynthesis cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL16_METCA
Sequence: MLQPKRTKYRKQHKGRNTGVAIAGSKVSFGEYGLKATTRGRITARQIEAARRTISRHVKRGGKIWIRVFPDKPVSKKPLEVRMGSGKGSVEFWVAEIKPGTMLYELEGVSEELAREAFRLAAAKLPVQTTFSLRTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: MMP14_MOUSE
Sequence: MSPAPRPSRSLLLPLLTLGTALASLGWAQGSNFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADLATMMAMRRPRCGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGSKSGSPTKMPPQPRTTSRPSVPDKPKNPAYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEEFRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGSGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPKRLLYCQRSLLDKV
What is the function of this protein?
Endopeptidase that degrades various components of the extracellular matrix such as collagen.  Activates progelatinase A.  Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (PubMed:10520996).  May be involved in actin cytoskeleton reorganization by cleaving PTK7 (By similarity).  Acts as a positive regulator of cell growth and migration via activation of MMP15.  Involved in the formation of the fibrovascular tissues (By similarity).  Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (By similarity).
What are the official names of this protein?
Matrix metalloproteinase-14, MMP-14, MMP-X1, MT-MMP, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein; Extracellular side. Melanosome. Cytoplasm. Note=Forms a complex with BST2 and localizes to the cytoplasm.
Protein: LYS3_CAEEL
Sequence: MKLFALLVSITLCYSFPAPLQTNVSEPFGLLQKVSEQVIDPDYNIPEVKDAPAIPYDERNSPTHAYSVDISFHTTPSDMDCLRDQGYKSVFVRALNPIGNTYFDRNALNTINNAFEAGLGSEVYITPNINSTRSGADQISLVYQNLLANGINVRSIWIQVTSPTNWVAPMAVRIEFIQDMIRSAKNLGLSVGIYTSFYDWLEITGGWNTFSSDVFLWYWHVLSMGTDGETTPTLEDFRPFGPWRQATVKQFGQVEKLCGMIVNRNVYSTGNQHLSQIVHFSTHQENSSSEKKLIRVGGIGF
What is the function of this protein?
Plays a role in the stress response to heavy metals such as copper, probably in a kgb-1-dependent manner.
What are the official names of this protein?
Lysozyme-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 25 family.
Protein: FLP3_ORYSJ
Sequence: MAGVWVFKDGIVRRVENPGSEESSSAGDGGGGGRRKVLVHVPSGEVVASYEVLERRLRELGWERYLTDPCLLQFHQRSTVHLISVPRDFSKFKLVHMYDIVVKTRNVFEVRDAAAPAVSPAT
What are the official names of this protein?
Flowering-promoting factor 1-like protein 3, FPF1-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the FPF1 family.
Protein: MPL_HAEIN
Sequence: MKHIHILGICGTFMGGVAMIAKQMGYHVTGSDTNVYPPMSTFLEEQGIEIIPNYDVAQLQPAPDMVIVGNAMKRGNPCVEYVLENNLKYTSGPQWLHDHLLRDRWVLAVSGTHGKTTTTGMLTWVLEQNGLKSGFLIGGIAGNFGISARLGDSPYFIIEADEYDTAFFDKRSKFVHYNPRTLIVNNISFDHADIFDDLKAIQRQFHHMIRTIPASGLVLSSASEQSAKETLALGCWSQQQFLGKDNEWFAERITNDASHFAVFHHGEKVAEVKWNVVGQHNMHNALMAIAAAHHTGVAIEDACKALGSFVNAKRRLEVKGEVNSITVYDDFAHHPEAILATLTALRDKVGGGVRILAVLEPRSNTMKMGVHKDDIAPALGRADAVFMLQPEQLSWEVADIANQCVQPAYWNANLDRLVDMIVAKAQPTDHILVMSNGSFGGIHQKILDKLKLK
What is the function of this protein?
Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase, Murein peptide ligase, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. Mpl subfamily.
Protein: NU5M_PANTR
Sequence: MTMYATMTTLALTSLIPPILGALINPNKKNSYPHYVKSIIASTFIISLFPTTMFMCLDQETIISNWHWATTQTTQLSLSFKLDYFSMTFIPVALFVTWSIMEFSLWYMDSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARTDANTAAIQAILYNRIGDIGFVLALAWFLLHSNSWDPQQMILLSTNTDLTPLLGFLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFYPLAENNPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDLIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLTIGSLFAGFLITNNILPMSTPQVTIPLYLKLTALGVTSLGLLTALDLNYLTSKLKMKSPLYTFHFSNMLGFYPNIMHRSIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQYQISASITTSTQKGMIKLYFLSFFFPLILTLLLIT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YCF70_ORYNI
Sequence: MVYGYGKSNMPHPNRKRKGTDTQYDYWEELLVMVSGLYALFCVFLVLFIFFDSFKQESNKLELSGKEEKKKLNGENRLSRDIQNLLYIK
What are the official names of this protein?
Uncharacterized protein ycf70, ORF89.
What is the protein family that this protein belongs to?
Belongs to the ycf70 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL27_STRAW
Sequence: MAHKKGASSTRNGRDSNAQRLGVKRFGGQVVNAGEILVRQRGTHFHPGSGVGRGKDDTLFALDAGAVEFGTHRGRKVVNIVPVA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RIMP_CROS5
Sequence: MTHPLIPQIIDLATPIVEEMGLDVVEVVFQTNKRPPVLRVDIRNPASDTSLNDCEQVSRALEAVLDETAIMPGAYVLEISSPGISRYLNSERDFIAFKGFEVNIATNPPYKDKKEWRGRLQGRDEKAVYLNRKGRAIAIPCAVITKVQLAD
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPB_BORBR
Sequence: MRFDKLTTKFQQALADAQSLAARNDHPYIEPVHVLAALLGDPDSGAASLLARAGVAVNRVQPAIDSALKGLPQVQGEDNVQVGRELQSVLVRTDKEAARRGDTYIASELFLLALADDKGDAGRILREAGLQKKALEAAIDAVRGGENVSGAEGESNREALSKYTLDLTERARQGKLDPVIGRDDEIRRTIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNDEVPETLRGKRVLSLDLAALLAGAKFRGEFEERLKAVLKELAQDDGQNIVFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYRKYIEKDAALERRFQKVLVGEPDVESTIAILRGLQERYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAGARIRMEIDSKPEVMDRLDRRIIQLKIEREAVKKETDDASMRRLAVIEEELEKLQREYNDYEEIWKAEKAAVQGTQAIKEEIDRVRAEMAELQRKGQFDKLAELQYGKLPELEARLKAADSAEREAGESDSGKPRLLRTQVGAEEIAEVVSRATGIPVAKMMQGERDKLLRMEDFLHKRVVGQDEAVRLVSDAIRRSRAGLADPSRPYGSFLFLGPTGVGKTELTRALADFLFDSEEHMIRIDMSEFMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTVIVMTSNLGSQHIQSMAGKPYEVIKEVVWDELKHTFRPEFLNRIDEVVVFHGLEAQHIESIARIQLKRLGERLEKQEMRLDVSDAALAEIARSGFDPVFGARPLKRAIQQQIENPVAKLILEGVFGPRDVVPVDWQDGKFVFTRTLQ
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJEN3_MOUSE
Sequence: MSSSVHNNTGPVQLPEERRFLSASEAAALERELLEEYRFGRQQLVELCGHASAVAVTKAFPLPSLSRKQRTVLVVCGPEQNGAVGLACARHLRVFEYQPSIFCPARSADALHRDLTTQCEKMDIPFLSFLPAEVRLIDDAYGLVVDAVLGPGVRLAEAGGHCARALATLKRLSIPLVSLDVPSGWDAEAGGDAKDAVQPDVLVSLAAPKSCAGRFSGRLHFVAGRFVPDDVRRKFGLHLPKYTGTDCVASL
What is the function of this protein?
May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.  May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential.  YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (By similarity).  May play a role in spermiogenesis and oogenesis (By similarity).
What are the official names of this protein?
YjeF N-terminal domain-containing protein 3, YjeF_N3, hYjeF_N3, ApoA-I-binding protein 2.
Protein: DKC1_CAEBR
Sequence: MGKKDKRSKLEGDELAEAQQKGSFQLPSSNETAKLDASQWPLLLKNYDKLNVRTNHYTPHVEGVSPLKRDIKNYISSGFFNLDKPSNPSSHEVVSWIKRILRCEKTGHSGTLDPKVSGCLIVCIDRTTRLAKSQQGAGKEYICIFKLHEEVEDERKVKQALEKLTGALFQRPPLISAVKRQLRIRTVYENKFIEYDPAQQMGIFNCICESGTYVRTICVHLGLILGCGGQMQELRRNRSGICDENENMVTMHDVLDAQYMLDTQKDESYMRHIVRPLEALLTQHKRVVVKDSCVNAICYGAKILIPGILRYDDDIEVGKEIVIMTTKGEAICIAIAQMSTSTIASVDHGIVAKSKRVIMERDVYGRKWGLGPVASKKKQMVKDGLLDKFGKPNITTPKSWAKEYVQTDKVKKEQEDKEDEEEEEAPKKKSKKAAKKEVSSSSDSE
What is the function of this protein?
Plays a central role in ribosomal RNA processing.  Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
What are the official names of this protein?
Putative H/ACA ribonucleoprotein complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: APAH_ECO55
Sequence: MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLQTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGIYALDTGCCWGGTLTCLRWEDKQYFVQPSNRHKDLGEAAAS
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: RL5_BORPD
Sequence: MSRLQDFYKSKVAPDLQAKFGYKSTMEVPRITKVTLNMGVSEAVADKKVIEHAVSDLTKIAGQKPVVTKTRKAIAGFKIRENYPIGCMVTLRGQRMYEFLDRLVAVALPRVRDFRGISGRAFDGRGNYNIGVKEQIIFPEIEYDKIDALRGLNISITTTAKTDDEAKALLTAFSFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.