PharMolix/UniProtQA huggingface dataset:
Protein: CAHAD_HOFGE
Sequence: MKTSSLTIIFIAVIITIICLNIHDIEAREIEFNAGRVVRSEKDCIKHLQRCRENKDCCSKKCSRRGTNPEKRCR
What is the function of this protein?
This toxin activates ryanodine receptors RyR1 and RyR2 by inducing a long-lasting subconductance state (35% of the full conductance stateon RyR1) (PubMed:19389159, PubMed:27114612).  Furthermore, it triggers calcium release from sarcoplasmic vesicles (11. 8 nM are enough to induce a sharp release on RyR1, and 55% of the total calcium is released after toxin (100 nM) addition on RyR1) probably by acting as a cell-penetrating peptide (CPP) (PubMed:19389159).  In addition, it has been shown to dose-dependently stimulate ryanodine binding to RyR1 (EC(50)=14. 8 nM) (PubMed:27114612).  It also augments the bell-shaped calcium-[3H]ryanodine binding curve that is maximal at about 10 uM calcium concentration (PubMed:27114612).  It binds a different site as ryanodine (By similarity).  It acts synergistically with caffeine (PubMed:19389159).  In vivo, intracerebroventricular injection into mice induces neurotoxic symptoms, followed by death (By similarity).
What are the official names of this protein?
Hadrucalcin, HdCa.
What is the protein family that this protein belongs to?
Belongs to the scorpion calcin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGJ_YEAST
Sequence: MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKNGSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCANSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEKFGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSKDFEQVKLQVTEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVKTALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQLEIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial, Extracellular mutant protein 40.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: YL182_MIMIV
Sequence: MCNFVFCFGSHNKKLLSDRIKSSKKGWYLYLGKKYRIGIKIITLSGRKYISVNFNKSIEFMKFLVRKNIHCNIFDQSHKCKSHNHYKNYLRYIIDNKCMDHIKIFYGKFFPLIRSQGRINNIIDIAKPLVLFENYTVDMDLGIDQETIMCIFKYGKMIDMASLLIHVLCTISDVTIEFLDDMLSIYRHKIIKLLTKEKHELDNDFNIMPMDVFLIPSFRNDDVDMFYFVVEEMFKLHDYIDTGNLTERELNVFNIFVYKLNADTINATINTHLIGLNHIHDFLVFYCPKIFNQLVLKLNDETSLNESIIFDILQLDFIEYMITVCETIGNNNPKILNKFLRYAKSTEMAQLLIDYDADYEKLYKSSKFHECNDCVKHFIENLVEETIDT
What are the official names of this protein?
Uncharacterized protein L182.
What is the protein family that this protein belongs to?
Belongs to the mimivirus L17x/L18x family.
Protein: PFKB_MYCTU
Sequence: MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPRYDPGGGGINVARIVHVLGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIPIAASTRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAFVVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHISSGVFLLKASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVSLGSQGALLATRHASHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSLIKSVRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:33540748).  Can also catalyze the phosphorylation of tagatose-6-phosphate.  The catalytic efficiency with tagatose-6-phosphate is about 1. 8 times lower than that with fructose 6-phosphate (PubMed:33540748).  Can use phosphate donors other than ATP (GTP and ITP), with lower efficiency (PubMed:33540748).  In addition, can catalyze the reverse gluconeogenic reaction, albeit with low efficiency (PubMed:33540748).  May support and maintain basic glycolysis and metabolic fluxes during conditions inhibiting PfkA (PubMed:33540748).
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase isozyme 2, ATP-PFK 2, Phosphofructokinase 2, Phosphofructokinase B, Phosphohexokinase 2, Tagatose-6-phosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: PA24A_CHICK
Sequence: MSFIDPYQHIVVEHQYSHVFTVTVRKATNVTKGAIGDMLDTPDPYVELFIPSAPDCRKRTKHFNNDVNPVWNETFEFILDPNQDNVLEVTLMDANYVMDETLGMATFPISSLKLGEKKEVQLTFNNVTEMTLELSLEVCSSTDLRFSMALCDEEKKFRQQRKDNIMQSMKSFLGEENSKNLTTSRDVPVIAVLGSGGGFRAMVGFAGVMKALYESGVLDCATYIAGLSGSTWYMSTLYSHPDFPEKGPKEINQELMNSVSHNPLLLLTPQKVKRYIEALWNKKSSGQPVTFTDIFGMLIGETLIHNRMDTTLSDMKEKVSEAQCALPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMSPDLFGSKFFMGTVVKKYSENPLHFLMGVWGSAFSILFNRVLGVSNSQNKGPTMEEELENIRLKHLVSNDSSDSEDESQHPKGTENSEANEEYQNSSQESWVQRMLMALVGDSALFNTREGRAGKVHNFMLGLNLNSCYPLSPLADLLTQESVEEDELDAAVADPDEFERIYEPLDVKSKKIHIVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKEILLAEKWAKMNKLPFPKIDPNVFDREGLKECYVFKPKDTSSEKDCPTIIHFVLANINFRKYKAPGLPRESKEEKDFADFDIFDDPNTPFSTFNFQYPNEAFKRLHDLMEFNTLNNLDVIKQAMMESIEYRKENPSRCSVSLSSVEARRFFNKNNLNNHT
What is the function of this protein?
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid.  Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
What are the official names of this protein?
Cytosolic phospholipase A2, cPLA2, Phospholipase A2 group IVA.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium- dependent fashion.
Protein: DLTA_BACMK
Sequence: MKLLEQIEKWAVETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAESSGAKLLLSGAEVTVTDLPVRITSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTKWTVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTSTPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKAAIMNTYGPTEATVAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKVFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRACSYVEGAVVVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFMYHSSIPMTPNGKVDRKKLLSEVTA
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPIL1_ASPFU
Sequence: MATDVVFDTSMGSFTVELYNEHAPKTCRNFATLAQRGYYNNVIFHRIIPNFMVQTGDPTGTGRGGSSIYGEKFEDEIHPGLKHTGAGVLSMANSGPNTNGSQFFITLAPTPWLDGKHTIFGRVKSGMRVIQRMGLVKTNSEDRPVDEVKIIRAKVVEEGDE
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase-like 1, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
Protein: RS20_SALPA
Sequence: MANIKSAKKRAVQSEKARKHNASRRSMMRTFIKKVYAAIEAGDKAAALKAFNEMQPIVDRQAAKGLIHKNKAARHKANLTAQINKLA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: UTP6_YEAST
Sequence: MSKTRYYLEQCIPEMDDLVEKGLFTKNEVSLIMKKRTDFEHRLNSRGSSINDYIKYINYESNVNKLRAKRCKRILQVKKTNSLSDWSIQQRIGFIYQRGTNKFPQDLKFWAMYLNYMKARGNQTSYKKIHNIYNQLLKLHPTNVDIWISCAKYEYEVHANFKSCRNIFQNGLRFNPDVPKLWYEYVKFELNFITKLINRRKVMGLINEREQELDMQNEQKNNQAPDEEKSHLQVPSTGDSMKDKLNELPEADISVLGNAETNPALRGDIALTIFDVCMKTLGKHYINKHKGYYAISDSKMNIELNKETLNYLFSESLRYIKLFDEFLDLERDYLINHVLQFWKNDMYDLSLRKDLPELYLKTVMIDITLNIRYMPVEKLDIDQLQLSVKKYFAYISKLDSASVKSLKNEYRSYLQDNYLKKMNAEDDPRYKILDLIISKL
What is the function of this protein?
Component of the SSU processome, a pre-ribosomal particle required for the maturation of the 18S rRNA from the 35S pre-rRNA precursor.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 6, U3 snoRNA-associated protein 6, U three protein 6.
What is the protein family that this protein belongs to?
Belongs to the UTP6 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NAGB_STAA2
Sequence: MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDNVSTFNLDEYVGLTASHPQSYHYYMDDMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDVLEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTESTIKANSRYFKNEDDVPKQAISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACPKNVAKIHVDEMD
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: RS7_SYNC1
Sequence: MPRRREVAKRVILPDPKYNDRTVAKFINAIMLMGKKSTAEGIVYGAFDLIAERSGEEALDVFKKAVENIRPMLEVKSRRVGGSTYQVPVEVRADRRNALAIRWLILYARGRGEKTMVERLAGELLDAAANRGAAVKKREDTHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SGK1_CAEEL
Sequence: MGSMYYNESRMVRKDEVTCNVIIGDDKKTVVYALRIGNGPIMQKTFEEYERFFTTEKDMIPATIFTAPKKKFLQADSKFYEKRRVWILVISQHLVDNNLRSEDVRRFFHLESPDDDENNVDLGPSERKTATANDFDYLTTIGKGSFGRVYQVRHKETKKIYAMKILSKEHIRKKNEVKHVMAERNVLINNFKHPFLVSLHFSFQNKEKLYFVLDHLNGGELFSHLQREKHFSESRSRFYAAEIACALGYLHEKNIIYRDLKPENLLLDDKGYLVLTDFGLCKEDMQGSKTTSTFCGTPEYLAPEIILKKPYDKTVDWWCLGSVLYEMIFGLPPFYSKDHNEMYDKIINQPLRLKHNISVPCSELITGLLQKDRSKRLGHRNDFRDIRDHPFFLPVDWDKLLNRELKAPFIPKVKNAMDTSNISKEFVEIQIDPSSLAPQQLAVTHRDHDFENFTFVDTNRVLV
What is the function of this protein?
Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway (PubMed:15068796).  Essential role in regulating development, stress response, and longevity (PubMed:15068796, PubMed:18782349).  Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function (PubMed:18358814).  Promotes the cytoplasmic localization of the transcription factor pqm-1 (PubMed:27401555).  Plays a role in the intracellular trafficking of proteins such as mig-14 to the cell membrane, and this may be through positively regulating ceramide synthesis (PubMed:26115433).  Acts downstream of rict-1 to regulate fat storage, size, development and vitellogenesis (PubMed:19240135, PubMed:19260765, PubMed:27401555).  Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development (PubMed:25383666).  Plays a role in maintaining the gonadal basement membrane through antagonizing akt-1 activity (PubMed:22916022).  Does not appear to play a role in immune function (PubMed:18782349).
What are the official names of this protein?
Serine/threonine-protein kinase sgk-1, Serum- and glucocorticoid-inducible kinase homolog, Serum/glucocorticoid-regulated kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Apical cell membrane. Note=Localized both in the cytoplasm and in the nucleus in neurons, exclusively cytoplasmic in the intestine. Localizes to the apical cell membrane and diffusely throughout the cytoplasm in intestinal cells (PubMed:26115433).
Protein: RPPH_CAMJD
Sequence: MENEKNYRPNVAAIVLSSSYPFECKIFIAKRSDMDNIWQFPQGGIDKGESAKNALFRELKEEIGTDEVEIIAEYPEWLSYDFPGKIVKKMYPYDGQIQKYFLVRLKHGATININTKHPEFDDYQFVSVKQIFEMINHFKKNIYVKVIKYFEEKGYI
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: RL36_CANAL
Sequence: MAKSGIAAGVNKGRKTTAKEVAPKISYRKGASSQRTVFVRSIVKEVAGLAPYERRLIELIRNAGEKRAKKLAKKRLGTHKRALRKVEEMTQVIAESRRH
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL36 family.
Protein: RBS_CAPAN
Sequence: MASSVMSTATVATGANAAQASMIASFNGLKSAASFPVTRKQDLDITSIASNGGRVECMLVWPPINKKKYETLSYLPDLSDEQLLKEIEYLLQKGWVPCLEFETEHGFVYREHHRSPGYYDGRYWTMWKLPMFGCTDATQVLNEVQEAKKAYPQAWIRIIGFDNVRQVQCISFIAYKPEATKFSMFNV
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYGA_DESOH
Sequence: MNGTMNFQEIILNLQRFWAKKGCVLVQPYDMEVGAGTFHPETLLRALGPEPWQVAYVQPSRRPTDGRYGENPNRLQHYYQFQVMLKPSPGNVQQLYLKSLATLGIFASDHDIRFVEDDWESPTLGASGLGWEVWLDGMEITQFTYFQAAGSIDLSPVSVEITYGLERIAMYMQGINNVYDLVWRDHITYGHLHHRQEVEQSAYNFEHADVEMLFDCFGKYEHEAGRMIAESLVLPAYEYCLKCSHTFNLLDARGAISVTERTGYIKRIRDIARACATTYLQQREEMGFPLLNAGHRGTTE
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AARE1_ORYSJ
Sequence: MATTQASEAATEKGLPLGMDVSMVDEYASQSKLLQEFVKIPTIGNAWIFNSKTENTSRAIVSVGQTDLLANKKRSFLLNSHISKNSSNSVDFQWSPFPIEMSGVSAVIPSPSGRKLLLIRNSEDDSPTKLEVWGPCQLENEIHIAQSVHGSLYVDEWFEGISWNQEETLVAYVAEEPPQPKPEFNDSGYKKAGSSEKDCKSWKGKGDWEETWGETYSKKRIPALFVVNISSGEVRAVKGIPRTLSVGQVIWAPSSSHSLVFVAWSSDNGYQKTPRKLGIKYCFNRPCALYAVPDPFMEEADKPSLNVSKGETAPTTKLTSELSSAFFPRFSPDGKYLVFISAKSAIDSGTHNATNSMHKIDWPADGKLEGLSVADVVPIVMCPQDGCFPGLYCSGILRNPWLTDGQTMILSSIWGSKEVILSVNVVSREVSRVSPQDSDYSWNVLALDKDNILAVSSSLITVPQIYYGSEVCQTGKPNQWEWQEIATPFPSPSDKISAILADHKFSILKIPISNSSNKLADGAKLPFEAIFVSWKDSATRPTIVVLHGGPHTVYPSSYSKSLAFLYSQGYNLLVVNYRGSLGFGEEALQSLPGNIGSQDVNDVLTALDFVIKKGLIDASKVAVVGGSHGGFLTTHLIGQAPGTFVAAAARNPVCNLSLMVGTTDIPEWCFVEIYGKEGKNCFSEYPSFDDLCQFHQKSPISHISKVSTPTLFLLGAQDLRVPVSNGLQYARTLKEMGVETKIIVFPEDMHGLDKPQSDFESFLNIGVWFKKHMSK
What is the function of this protein?
Catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.
What are the official names of this protein?
Acylamino-acid-releasing enzyme 1, AARE1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y727_METJA
Sequence: MKIRGFESSMMGKDIDFIPPAMTRLCCLNEISHALAGVMAVEKAYNITVPNEGQYLREIARLGEIVEVDAIKLREFKNTDDLADIGNKIKSVLGKKAKYLAVGGVLENISDKRKEKLINLAKEGLNLVDKDFVKLVDERKAKIPLPDVELIDAYNFDANKVETNGLPKTALYDGKVVYSGSLARMYKEGLINSKNLWDVLSSRMIEIEFCLNKIIELLNKLKLTHPYMEPIIKDGKAIGEAVIEGGEGIVYHKVELLGREILDYTILTSENFNKAVLDSVDNDEAKRIIQLCERCYYL
What are the official names of this protein?
Uncharacterized protein MJ0727.
Protein: LEPA_CITK8
Sequence: MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVTLDYKAADGETYHLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSWFDNYLGVVSLVRIKNGTMRKGDKVKVMSTGQVYNADRLGIFTPKQIDRTKLKCGEVGWLVCAIKDIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLFPVSSDDYENFRDALGKLSLNDASLFYEPESSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTAKEIIYVDSPSKLPPLNNIYELREPIAECHMLLPQAYLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINNERVDALALITHRGNSQSRGRELVEKMKELIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDSK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS15_LACDA
Sequence: MAVSKERKNEIIKEYATHEGDTGSVEVQVAVLTEDINNLTQHMREHSHDHHSYVGLLKKIGHRRNLLRYLQENDLERYRALIARLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: DAPF_SALPA
Sequence: MQFSKMHGLGNDFMVVDAVTQNVFFSPELIRRLSDRHLGVGFDQLLVVEPPYDPELDFHYRIFNADGSEVSQCGNGARCFARFVRLKGLTNKRDIRVSTANGRMVLSVTEDELVRVNMGEPNFEPAQVPFRANKAEKTYIMRAAEQTILCGVVSMGNPHCVIQVDNVDTAAVETLGPVLESHERFPERANIGFMQVVRREHIRLRVYERGAGETRACGSGACAAVAVGIQQGLLAEEVRVELPGGRLDIAWKGPGHPLYMTGPAAHIYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_THEYD
Sequence: MNVGKVVQVIGTVVDCEFEGQLPEVLNALKIEEPGDPAKGIPELHLTLEVAMHLGENRVRTIAMGSTDGLVRGMKVVDTGAPITVPVGKPVLGRIINVIGEPVDEMGPIQAQDKYPIHISAPEFTEQSPTTQQFETGVKVFDLLVPFVRGGKMGMFGGAGVGKTVIIMEMIHNIAMKHGGVSVFAGVGERTREGNDLYLEMKHSGVLPQVALVYGQMNEPPGVRARIALTALTVAEYFRDQGQDVLIFIDNIFRYTLAGSEVSALLGRMPSAVGYQPTLSTEMGALQERITTTAKGSITSMQAIYVPADDLTDPAVAAVFAHLDGTVVLSRQIAELGIYPAVDPLDSTSRILDPRVVGDEHYQVARGVQSVLQRYKELQDIIAILGIEELSEDDKLTVARARKLQRFLSQPFHVAETFTGTPGKYVKLEDTIKGFKAILDGKYDDLPEQAFYMVGPIEEVEEKAKKMGYTRQV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYP_WIGBR
Sequence: MRTSQYYLATLKDSPSETEGISHRLMIRSGMIRKLSSGLYAWLPTGFRVLKKIENIIRHEMNKIGAIEILMPIIQPSLIWKNSGRYEEYGLELLKFYDRKKKQFVLAPTHEEVISKIILKEINFNKVFPINFYQIYSKFRDEARPRCGTMRSKEFVMKDSYSFHLNEKSLEKTYHIMQETYKKIFNRLNLDYFVIRAKTGKIGGFISHEFHAYYNKSDVLINSYKKIFDKNNIINKFKKKIEIKNLIEINAEDILLTSDLAKKFNIDIKQIIKILLVHSIEKNHPFIAIAIREDHEIDLQKVENLNQVKKPLKFANYYEINKYFKVKKSYLGPVNIKCLLIVDKEAHCIKNFVSGANINNKYFFNINWDRDVVSYLVYDLKLCRKKYNNKKNNNSIEIGHIFQLGDKYSKPLNYSLLKDYNKKKIFMGCYGIGISRLVSTYIEQNYDSNGIIWNEEIAPFKVAIIPININFSIKVKNFSEEIYYKLCNLKIDVLFYDNVERPGIMFSNIELIGIPHILIISDKNLKNSIIEYKNRITGDKLMINYKYIFDFLLQFNINFNF
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZFPL1_XENTR
Sequence: MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHAKCIVQSYLQWLQDSDYNPNCRLCNTLLSSKETARLVCYDLFHWSCLNDLATQLPPNTAPAGYRCPSCQGPVFPPSNLVSPVAATLREKLSTVNWARAGLGLPLIEVAEPVDDTMSHDETDYRDWSVVNSSSDNLSETPETTSQTGYAYNSVPTSVAQHSLNVNMSQDHAVTIRDTGSDSLTINAGSSPRKVYDTRETARGQDAVIDFDDDKYRRRPTLSWLARILRNRSGSKSRPASSMQRFLVILIIGVLGFLTLILLMSKLGRASADNDPNLDPLLNPHIHVGKE
What is the function of this protein?
Required for cis-Golgi integrity and efficient ER to Golgi transport.
What are the official names of this protein?
Zinc finger protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the ZFPL1 family.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein.