PharMolix/UniProtQA huggingface dataset:
Protein: HEM3_DICDI
Sequence: MSSITKRDKVIIGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTKELEDMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSELPQGAMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERMELTDHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRDLEGGCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQDLINKGSKDILSEFIKK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, Heme biosynthesis protein C, Hydroxymethylbilane synthase, HMBS.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: TOP1M_HUMAN
Sequence: MRVVRLLRLRAALTLLGEVPRRPASRGVPGSRRTQKGSGARWEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFEF
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
What are the official names of this protein?
DNA topoisomerase I, mitochondrial, TOP1mt.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MTNB_AEDAE
Sequence: MNLQVRLQDAALDGVGNHRHRMEHPRKLIPELCKQFYNLGWVTGTGGGISIKLDDEIYIAPSGVQKERILPDDLFIQNIDGDDLQLPPDYKKLTKSQCTPLFMLAYREKNAGAVIHTHSQSAVIATLVWPGREFRCTHLEMIKGIYDHELGRYLRFDEELIVPIIENTPFEKDLEQRMEHAMKEYPGSSAVLVRRHGIYVWGHTWQKAKAMAECYDYLFSLTVEMKKLGLDPNDIPKYYRSNK
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Probable methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_TREPA
Sequence: MSEVFPKIGRRRARILAFQALFAWDAAGITPETLTQFTWLRRNPPPSTQDLGFSRLLFLGTLEHLREIDGCVSSRLEHWDFVRLNKVDKAILRLSAYSLLFQKDIPPVVVIHEAVSIARDFGTDDSFRFVNGVLDNIAKSA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RL19_STAES
Sequence: MSNHKLIEAVTKSQLRTDLPTFRSGDTLRVHVRIVEGSRERIQVFEGVVIKRRGGGISETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYLRSLRGKAARIQEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: THIC_JANMA
Sequence: MNANPKFLSATATVDEASIQPLPNSRKIYIEGSRPDIRVPMREITQSDTAASFGFEKNPPIYVYDTSGPYTDPAAKIDIRSGLDTPRLPWILERNDTEELPGPTSEYGIERLNDPKLAELRFNLHRKPRRALAGKNVSQMHYARQGIITPEMEFVAIRENMNRRAYLEELKKSGPKGEKLAELMGRQHPGQSFGAAIPQEITAEFVRSEIARGRAIIPANINHPEIEPMIIGRNFLVKINANIGNSAVTSSIGEEVEKMTWAIRWGGDNVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEDICEIMKAYDVSFSLGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQVMIEGPGHVPMHLIKENMDLQLEQCHEAPFYTLGPLTTDIAPGYDHITSGIGAAQIGWYGTAMLCYVTPKEHLGLPNKVDVKDGIITYKIAAHAADLAKGHIGAQIRDNALSKARFEFRWEDQFNIGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQEVRDYAAKQGITEIQALKAGMEVKAIEFVKSGSEIYQKQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: XERC_RICRO
Sequence: MLDTSIQALINKWQKYLVLQRNYSNHTVISYNNDLKHFLEFMNYYNSELVTINHIKTADIRLIRSWLAKRNCDNFAASSISRGLSAVKNFYRFLEKTTQLNSHIIFSIKSPKKTKLLPKALSEDDVVISLEHIEEYGNIKWVELRNKALLVLIYASGLRISEALSITKLHLQNLEFIRIIGKGSKERIIPWLPIAKNLITQYLEILPYKLGDNEPIFRGKQGKKLQPPVFNRELIKLKHFYGLPQHLTAHSFRHSFASHLLEHGADLRSLQALLGHKSLSTTQNYTKTSIKHLEAVYTTAYPIKK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S35D3_HUMAN
Sequence: MRQLCRGRVLGISVAIAHGVFSGSLNILLKFLISRYQFSFLTLVQCLTSSTAALSLELLRRLGLIAVPPFGLSLARSFAGVAVLSTLQSSLTLWSLRGLSLPMYVVFKRCLPLVTMLIGVLVLKNGAPSPGVLAAVLITTCGAALAGAGDLTGDPIGYVTGVLAVLVHAAYLVLIQKASADTEHGPLTAQYVIAVSATPLLVICSFASTDSIHAWTFPGWKDPAMVCIFVACILIGCAMNFTTLHCTYINSAVTTSFVGVVKSIATITVGMVAFSDVEPTSLFIAGVVVNTLGSIIYCVAKFMETRKQSNYEDLEAQPRGEEAQLSGDQLPFVMEELPGEGGNGRSEGGEAAGGPAQESRQEVRGSPRGVPLVAGSSEEGSRRSLKDAYLEVWRLVRGTRYMKKDYLIENEELPSP
What is the function of this protein?
May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.
What are the official names of this protein?
Solute carrier family 35 member D3, Fringe connection-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PFD5_CAEBR
Sequence: MTEEQRGVPLSELSLQQLGELQKNCEQELTFFQDSFNALKALLSRNEKSISALEDVKVGTAGHTALIPLSESLYIRAELSDPNKHMVEIGTGYFVELDREKAKGIFDRKKEHIAKQVETVEGILKEKRRTRAYISDAFQTKVQAQLANMNTQQS
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
What are the official names of this protein?
Probable prefoldin subunit 5.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit alpha family.
Protein: RF1_STAAW
Sequence: MFDQLDIVEERYEQLNELLSDPDVVNDSDKLRKYSKEQADLQKTVDVYRNYKAKKEELADIEEMLSETDDKEEVEMLKEESNGIKAELPNLEEELKILLIPKDPNDDKDVIVEIRAAAGGDEAAIFAGDLMRMYSKYAESQGFKTEIVEASESDHGGYKEISFSVSGNGAYSKLKFENGAHRVQRVPETESGGRIHTSTATVAVLPEVEDVEIEIRNEDLKIDTYRSSGAGGQHVNTTDSAVRITHLPTGVIATSSEKSQIQNREKAMKVLKARLYDMKVQEEQQKYASQRKSAVGTGDRSERIRTYNYPQSRVTDHRIGLTLQKLGQIMEGHLEEIIDALTLSEQTDKLKELNNGEL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTRA1_ARATH
Sequence: MSSQIALSPAIAAAIRRPSSHDCLSASATTATATPMALKSCIVAPLSLFTSQSQIKHSSSRKTSRTTIRCDVAIKSADSINADANPSSSPSSEEEIEAEAKAKIGSRVRVTAPLKVYHVNRVPEVDLEGMEGKLKDYVAVWKGKRISANLPYKIEFFKEIEGRGLVKFVSHLKEDEFEFIDQ
What is the function of this protein?
Variable subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
What are the official names of this protein?
Ferredoxin-thioredoxin reductase subunit A1, chloroplastic, FTR-A1, Ferredoxin-thioredoxin reductase, variable chain FTRA1, FTR-V 1.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin thioredoxin reductase alpha subunit family.
Protein: SELU_CUPTR
Sequence: MRPDTSDFRELFLSGVAMLDVRAPLEFARGAFPGAVNLPLMDDAERHEVGLCYAQKGQQAAIELGHELVSGQRKAARIAAWAEFARAHPDGYLYCFRGGLRSQLVQQWLRDAGVDYPRVSGGYKAMRGFLIETIDTAAATQPWFVVGGLTGSGKTDVLADVPASIDLEGHARHRGSAFGRRALPQPPQIDFENALAIDVLHHLDAGWRALVVEDEGRFIGSRDVPQALSQRMQASPLVWLEAPFNARVERVLRDYVQGLAAEFIDTKGSAEGFAAYATRLREAMAAIAPRLGGARYGKLAALLDQALARQAESGEVALHRGWIEVLLRDYYDPMYDYQRAQREARIVFRGDRDAVTDWLLAHTARQGE
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: SAHH_PELPB
Sequence: MTTLTEVLDYKVADLSLAEWGRKEIDVAEKEMPGLMATRRKYAGQYPLKGARIAGSLHMTIQTAVLIETLVELGAEVRWASCNIFSTQDHAAAAIAKSGVPVFAWKGETLEEYWWCTRQILEFEGGKGPNLIVDDGGDATLMIILGYKIENNPELLEKAPANLEEKALYQQFREVFAEDSQRWHKVAAEMKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESLADGIKRATDVMVAGKVVVVLGYGDVGKGSARSMRAYGARVIVTEIDPICALQAAMEGYEVSTMDEAVKEGNIFVTTTGNKDVITLEHMKQMKDEAIVCNIGHFDNEIQVEQLYAYAGATRLNIKPQVDKYTFENGNCIYLLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELWTKDYAVGVYRLPKELDEEVARLHLEQLGVKLTRLSDEQAAYIGVPLDGPYKPEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_THEP1
Sequence: MIQQETYLNVADNSGAKKLRVIRVIGGFHKKYGTVGDIVVCSVREAIPNSDVKKGDVVRAVIVRTKKEIRRSDGTYIRFDDNAAVLIDKFNAPRGTRIFGPVARELREKGFMKIVSLAPEVW
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RLR19_PLAHL
Sequence: MRSCQYLLLLFLASDTSNDAISEPTRKSQLQKIESKRGSVTQWEIHGSRLLRSSGGKIKANEERMETEMSKLGALFSRGIKAMKLVHSTSFKTLLHLKNNVFANIMETEGALHALMLGFHPLEVKSRLEHDHDIAVQLKLSLTHWERNPETKNLLSLLEKQNEWMKSIQPPASLSAGIKFWEEGLQKLDSLSCLNAEKILEETISQLSQEGLSGEALVEKNLSPFVYGTALYYMGKEQAKVLSGEEFSAWYNNQLKRFANFVNAYRDKLNLPPRYAKLHLFADFEVHDGVAT
What is the function of this protein?
Secreted effector that suppresses pattern-triggered immunity (PTI) in plant host.
What are the official names of this protein?
Secreted RxLR effector protein RXLR-C19.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus.
Protein: TP1_ODOVE
Sequence: MFTLKKSLLLLFFLGTINLSLCEEERDADEEERRDDPDEMNVEVEKRFLPLVGKILSGLIGK
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Temporin-1V, temp1v, 1VE.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2346_XYLFA
Sequence: MLIAWPDRVHCCEIMLQEGARVVDAVEMAALNGIEQAVGYAVFGVLVTSDHVLNEGDRVELLRPLLIDPKEARRRRAVSA
What are the official names of this protein?
UPF0125 protein XF_2346.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: MURB_LACAC
Sequence: MELLNLKKQGIDIKEQIPLSRYTFTKTGGEAEYLAFPKTTDEVEKLVKVTQENKIPLTIIGNASNLIIRDGGIDGLVIILTELKNIEVNGNEVTADAGATIVDTAFTAANHGLSGMEFAAGIPGSIGGGVFMNAGAYGGEMQEAVKSVNVLTRAGEYKTYSNQEMDFSYRHSIIQENGDIVLSATFSLKPGNKLQILDHMDYLNALRRYKQPLEYPSCGSVFKRPKGHFVGPMIIKAGLQGKQIGGAQDSTKHAGFIVNKGGATATDYLDLIHLIQKVIKEKYDIDLHTEVRIIGKEN
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPE_CERS4
Sequence: MPIDPVALTADLVRCPSVTPEEGGALDLIERILSGAGFDCTRVDRNGVPNLFARWGRKGANRTFGFNGHTDVVPVGDAAAWTRDPFGGEIADGWLWGRGATDMKSGVAAFVAAAVDFVQETPPDGAVVLTITGDEEGDSTDGTVALLDWMAAEGEAMSVCLVGEPTCPERLGEMMKIGRRGSMTAFFTARGVQGHSAYPHRAKNPVAALARLIDRLSSHDLDYGTEHFDASTLAVTTFDTGNPATNVIPALCRATVNIRFNDAHSGASLTRWLEEEAARVAADTGVEIALSAKISGESFLTPPGELSELVARAVEAETGLRPEPSTSGGTSDARFVRAHCPVVEFGLVGKTMHQVDERVEVAQIEPLKAIYLRILKDYFA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: RPOB_GEOSM
Sequence: MAYSIANNPLLRKNFAKIHKIIDIPNLIDIQKNSYKRFLQLDTPVDARKNSGLEAVFRSVFPIRDFSDTASLEYVSYSLGAPKYDVEECHQRGMTFAAPMKVKVRLVVWDVAKDPGTRSIRDIKEQEVYFGEIPLMTDNGTFIINGTERVIVSQLHRSPGVFYDHDKGKTHSSGKVLYSARVIPYRGSWLDFEFDHKDILYVRIDRRRKMPATVLLKALGYSNDALINYFYKSEDVKVGDNGSMTKIADAELLSNQKATADIVDPATGEVILKANRKFTKAAIRKMSEHGIKEIPISEEEVVGKVASHDIYDPATGEIIVECNEELTQAKLEEIIQKGITTFQVLFIDNLHVTSSFRDTILIDKIGSTDEALIEIYRRLRPGDPPTLKSALVLFENLFFNAERYDLSAVGRLKLNYKLGVDVPLDCMTLTREDILEVVRYLIELKNGKGNIDDIDHLGNRRVRAVGELLENQYRIGLVRMERAIKERMSLQEVENLMPHDLINSKPVSAVVKEFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLIASLSTYARINEHGFVETPYRVVKEGRVTDEVRFFSALEEEGHAIAQANAEIDETGRFAADYISARKSGEFVLVGRDELELMDVAPMQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLRADSPLVGTGMERVVARDSGVSLVARHNGVVESVDASRIVVKIDEDQYDATGTGVDIYNLIKFARSNQNTCINQRPLVKVGDHVTAGDIIADGPSTDMGELALGQNVLIAFMPWGGYNYEDSILISERLVKDDRYTSIHIEEFEAVARDTKLGKEEITSDIPNLGEETLKDLDESGIIRIGAEVRPGDILVGKITPKGETQLSPEEKLLRAIFGEKAGDVRDTSLRVPPGVEGTVIGAKIFSRKGADKDARTEIIEKAEEMRLRKDEQDEIRIIRDSAIGKLKKLLVGKTAAVKIEGTDGKVLIPKGAAITEEMLKSFSMDRWDEISIADDDTVDEKVAQTLSTLNQQIDIIKYVFDDKVQKLRRGDDLPPGVIKMVKVYIAIKRKLQVGDKMAGRHGNKGVVSRILPEEDMPYMEDGRPVEIVLNPLGVPSRMNVGQILEMHLGWAAKGLGWKIEEFLDKNAPHDEIKRFLKGAYNNPDMDRFLDKLEGEELLNVAKRLKRGVPMSSPVFEGASEESIQSMLSHAGFSTTGQVTLFDGKSGDKFMHQVTVGIMYFLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRLGEMEVWAMEAYGAAYALQEFLTVKSDDVAGRTRMYEAIVKGKHTLEPGLPESFNVLIKELQSLGLDVELLEGDED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: DEF_SALPA
Sequence: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGNPFELEADGLLAICIQHEMDHLVGKLFIDYLSPLKQQRIRQKVEKLDRLNARA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: COX1_DROSE
Sequence: PRQWLFSTNHKDIGTLYFIFGAWAGMVGTSLSILIRAELGHPGALIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALSLLLVSSMVENGAGTGWTVYPPLSAGIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGISLDRMPLFVWSVVITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESGKKETFGSLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQLSYSPAILWALGFVFLFTVGGLTGVVLANSSVDIILHDTYYVVAHFHYVLSMGAVFAIMAGFIHWYPLFTGLTLNNKWLKSQFITMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTTWNIVSTIGSTISLLGILFFFFIIWESLVSQRQVIYPIQLNSSIEWYQNTPPAEHSYSELPLLTN
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MOT4_CHICK
Sequence: MGAVVVDDGPSGVKAPDGGWGWAVLFGCFIITGFSYAFPKAVSVFFKELIREFGVGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASMGMVIASFCTSIVQIYLTAGVITGLGLALNFQPSLIMLNRYFDKRRPLANGLSAAGSPVFLCALSPLGQILQHEYGWRGGFLILGGMLLNCCVCGALMRPLEPPKKSEATKEPAEKKAKKKLLDFSVFKDGGFVIYTLAASIMVLGLFVPPVFVVSYAKDLGYQDTKAAFLLTILGFIDIFARPICGMVAGLKWVRPRCVYLFSFAMIFNGFTDLMGSMSVDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLAEAMAVLIGPPSAGKLLDLTRRYMFVFIIAGIEVTTSALVLALGNFFCIKKKPAEPHTKEAAAEREELNKSEDKTPEDAKVDSIEVEQFLKDEPEKNGEVVTNPETCV
What is the function of this protein?
Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (By similarity).  Plays a predominant role in the L-lactate efflux from highly glycolytic cells (By similarity).
What are the official names of this protein?
Monocarboxylate transporter 4, MCT 4, Solute carrier family 16 member 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Plasma membrane localization is dependent upon the BSG/MCT4 interaction. Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression in polarised epithelial cells.
Protein: ACT2_TETPY
Sequence: MTDSDSPAIVIDNGSGMCKAGIAGDDAPRAAFPSIIGRPKMPGIMVGMDQKECYVGEEAQAKRGVLNLKYPIEHGIVTDYDDMEKIWHHCFYNELRVTPEEHPCLLTEAPQNPKLNREKMTKTMFETFNVPSFYVAIQAVLSLYASGRTTGIVVDSGDGVTHTVSIYEGYALPHAILRIDLAGRDLTEYCMKLLYEIGLNFSSTAEREIIRDIKEKLCYVALDYESELKAYKESSTNDKSYELPDGNTITVQDQRFRCPELLFKPAFIGKEFPGIHELTFNSIMKCDVDVRKDLYNNIVLSGGTTMFPGIAERLSKEVSALAPSSMKIKVVAPPERRYSVWIGGSILSSLSTFQTMWITKAEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, cytoplasmic, Actin, micronuclear.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TRMD_LACPL
Sequence: MQIDILSLFPEMFAGPLHESMIGNAIENDVINVDVTNFRDFTTDKHNHVDDYPYGGGAGMLLQPQPIFDALASVQEKHPAPGRVILLDPAGVQFNQHVAEDFAQEEHLTFICGHYEGYDERIRSLVTDEVSLGDYVLTGGELGAMVMIDATVRLLPGVLGNSESAPGDSFSSGLLEYPQYTRPADFRGMKVPDILLSGDHGKIDDWRLEQALKRTYERRPDMLTGLSLSGKAKQMLADIKADESEV
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_SHISS
Sequence: MKPTTIASLQKCKQDKKRFATITAYDYSFAKLFADEGLNVMLVGDSLGMTVQGHDSTLPVTVADIAYHTASVRRGAPNCLLLADLPFMAYATPEQAFENAATVMRAGANMVKIEGGEWLVETVKMLTERAVPVCGHLGLTPQSVNIFGGYKVQGRGDEAGDQLLSDALALEAAGAQLLVLECVPIELAKRITEALAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYMAEVESGVYPGEEHSFH
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBXH_BACSU
Sequence: MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEYPDHDLIEELVNHYCFEHEI
What are the official names of this protein?
Uncharacterized protein YbxH, ORF3.
Protein: RL31_PYRHO
Sequence: MRMIKPGEEVIFTVPIRKVKKIVPRWKRAPRAVKFVREFIARHAKAQEVIISTKVNEKIWERGIEKPPSKLRVKVRVEEEEREGGKVRIAYVDLA
What are the official names of this protein?
50S ribosomal protein L31e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
Protein: MNHC1_STAA8
Sequence: MEIIMIFVSGILTAISVYLVLSKSLIRIVMGTTLLTHAANLFLITMGGLKHGTVPIYEANVKSYVDPIPQALILTAIVIAFATTAFFLVLAFRTYKELGTDNVESMKGVPEDD
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit C1, Mnh complex subunit C1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.