PharMolix/UniProtQA huggingface dataset:
Protein: CAPP1_CHLRE
Sequence: MQLSATSGRTSFRVSQDLRTGPANFLSGLRDDDSLLRQVFFSILRHHHPNLAAKVDVIYALSQAWCTSQSDNDFELMVKYVSDLKPEERILVASSFSHMLNLHNLTEEVNSSQIGRAVRLGEMDSPTRDTNHSLLKLTTTNGFTPQQVYDTLCSQTVELVLTAHPTQALRASLLKKYAIVRRELDTLHSKRMSEYEKIETLEAIRAAVQAAWRTDEIRRSKPTPQDEMRSGLSYFSTVIFDVVPVFHRRVDTALEKLGLPRLPLDRALFKFGSWMGGDRDGNPNVTAETTRDVVVLARLEAVNVYFRQVEGLMFDLSIWRCSPEMKELAERLAAAESRDAARVAEERKRRNYVDFWAPIPPTEPFRVVLAHMRDRLYNTRQVLHQCLIHTHMSVRGALEEAGAYVDIEDMARPLKLMYDSLMSTGDESVANARLLDLLRQIRTFGLCMMGLDVRQESTRHTEVMDAVTTYLGLGSYASWDEPKRLAFLLGELQGKRPLMPPGMDMSPEVKEVVRTLRILSELPGDSLGAYIISMAKTASDVLAVVLLQRETGVRPALRVVPLFETLDDLHNAPGTMTTLLGNDWYRGHINGVQECMIGYSDSGKDAGRLAAAWALYETQEKLVEVAAGCGVRLVLFHGRGGTVGRGGGPTHMAIRSQPSGTINGHLRVTVQGEIIEQQFGEKEVCFRTLDLYTSAVLEAALDPPPAPAQEWRDLMSLLATESCDMYRSVVYRTPEFYDYFMQSTAASELGRLNIGSRPSSRKSGGIETLRAIPWIFAWTQQRLHLPVWLGIGEALEAAIDKGYGPVLQDMYANWPFFTSTLDLVEMVLAKADSRLSAFYERTLVDSSLAPLGQRLRELLAKTQQNILIVVRKSVLLEGNTPSQMSTPNLDEKIRLRSPYVAPLNVLQALSLQGLRKFRDGGDTEYNPSDPEIIDLLSRDPHKKGEGAQHPFVSAMDDCLMITIKGIAAGMQNTG
What is the function of this protein?
Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase 1, PEP carboxylase 1, PEPC 1, PEPCase 1.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_GRAFK
Sequence: MMILMEYHNPVLLKESVDGLDVKPDGIYVDVTFGGGGHSKEILKRLGPDGKLYAFDQDKDALENKIEDGRFTLINENFRYLKRFLRFYGIKKVDGVLGDFGVSSHQFNEAERGFSTRFDAKLDMRMNQGDKLSAYEVINEYEEEQLKKLFWAYADLKNAPKLARTIVSERKNNPIETSEQLNDLLKPLLFKGKENKILAQIYQAIRIEVNQEIEVLKEFLLQTEEILKPGGRLSLISYHSLEDRLVKRYIRSGLFEGEPEKDMYGNISVPFKKVNGLIIPSKEEIQQNNRARSAKLRVARKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_ECO27
Sequence: MKPNIHPEYRTVVFHDTSVDEYFKIGSTIKTDREIELDGVTYPYVTIDVSSKSHPFYTGKLRTVASEGNVARFTQRFGRFVSTKKGA
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: ASSY_SALNS
Sequence: MTTILKHLPAGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHSHGRQLGKLLYQGRWFDSQALMLRDGLQRWVASQITGEVTLELRRGNDYSILNTVSDNLTYKPERLTMEKGESVFSPDDRIGQLTMRNLDITDTREKLFGYAKAGLLTASSATGLPQVENLENKGK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_EPOWA
Sequence: MTNIRKSHPLLKIINDSLIDLPAPSNISSWWNFGSLLGICLGIQILTGLFLAMHYTSDTATAFQSVTHICRDVNYGWILRYLHANGASMFFICLFLHVGRGLYYGSYIFMETWNVGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTSLVEWIWGGFSVDKATLTRFFAFHFLLPFIIAALVMVHLLFLHETGSNNPTGIPSDMDMIPFHPYYTIKDMLGALAMILALLALVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILILMPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFIIIGQLASILYFSLILILMPFVSIMENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PESC_NEUCR
Sequence: MPKIKKKGQAGAAKNYITRTQAVKKLQLSLPDFRKLCIWKGIYPREPRNKKKVSKSATASTTFYYTKDIQYLLHEPLLQKFRDQKVLEKKISRALGRGDVSDAARFERHAARPEATGKPRYTLNHVIRERYPTFNDALRDLDDCLSMLFLFANLPSTSAVPAKMIARCERLCLEFQHYLIVSHSLRKSFLSIKGIYYQANIQGEDILWLVPYKFNQRIVGDVDFRIMGTFVEFYMTLLGFVNYRLYSSIGLKYPPKFDQLKDENGAELGAFSLEGVNMATQGETKAVTNGEEQQQGPDPKVQAEVDKIIKQLKEDESKSDETAEEDAEADDEEKPTDSIDKFEPVAPGGDVLPQPAYSSSDPSQLFANFTFYLSRETPRQPLEFILRAFGCKRIGWDSVLGEGAFTNDESDPSITHHIIDRPVVQAATNEDGDGEDNQTAQKVGPNQRYPGRIYVQPQWVWDCVNDEELKSPELYAPGAALPPHLSPFVKAAPGQYDPTLPLEAQQTEAEAIEADLEDAEKGNAEDGSDVENDMDVDEAEDDEEEEEGDEEDAEEAEEEDAEEDEEESKTLQRQLELEAELQGKKVQNTKVDSKTKAKLEQRKALEKKAREEAEDLERAKGMLSKKKRKLFEQMQYTNNKKSAQDEKLRAKRRKLEKEKAQKA
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Pescadillo homolog, Nucleolar protein 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the pescadillo family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: RPOC1_CAPBU
Sequence: MIDRYKHQQLRIGLVSPQQISAWATKIIPNGEIVGEVTKPYTFHYKTNKPEKDGLFCERIFGPIKSGICACGNYRVIGDEKEDPKFCEQCGVEFVDSRIRRYQMGYIKLTCPVTHVWYLKRLPSYIANLLDKPLKELEGLVYCDFSFARPITKKPTFLRLRGSFEYEIQSWKYSIPLFFTTQGFDIFRNREISTGAGAIREQLADLDLRIIIENSLVEWKQLGEEGPTGNEWEDRKIVRRKDFLVRRMELAKHFIRTNIEPEWMVLCLLPVLPPELRPIIQIEGGKLMSSDINELYRRVIYRNNTLTDLLTTSRSTPGELVMCQEKLVQEAVDTLLDNGIRGQPMRDGHNKVYKSFSDVIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHRCGLPREIAIELFQTFVIRGLIRQHLASNIGVAKSQIREKKPIVWEILQEVMQGHPVLLNRAPTLHRLGIQSFQPILVEGRTICLHPLVCKGFNADFDGDQMAVHVPLSLEAQAEARLLMFSHMNLLSPAIGDPISVPTQDMLIGLYVLTSGTRRGICANRYNPCNRKNYQNERIYETNYKYTKEPFFCNSYDAIGAYRQKRIDLDSPLWLRWQLDQRVIASREVPIEVHYESFGNYHEIYAHYLIVRSVKKETFCIYIRTTVGHISFYREIEEAIQGFSQACSYDT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AGAL_CYATE
Sequence: MATHYSIIGGMIIVVLLMIIGSEGGRLLEKKNRTSAEAEHYNVRRYLAENGLGQTPPMGWNSWNHFGCDINENVVRETADAMVSTGLAALGYQYINLDDCWAELNRDSEGNMVPNAAAFPSGIKALADYVHSKGLKLGVYSDAGNQTCSKRMPGSLGHEEQDAKTFASWGVDYLKYDNCENLGISVKERYPPMGKALLSSGRPIFFSMCEWGWEDPQIWAKSIGNSWRTTGDIEDNWNSMTSIADSNDKWASYAGPGGWNDPDMLEVGNGGMTTEEYRSHFSIWALAKAPLLVGCDIRAMDDTTHELISNAEVIAVNQDKLGVQGKKVKSTNDLEVWAGPLSDNKVAVILWNRSSSRATVTASWSDIGLQQGTTVDARDLWEHSTQSLVSGEISAEIDSHACKMYVLTPRS
What is the function of this protein?
Involved in the hydrolysis of the galactomannan, it splits alpha-linked galactose moieties.  It is particularly suitable for the hydrolysis of guar gum to a gum with improved gelling properties.  Preferentially cleaves alpha-1,6 glycoside linkages.
What are the official names of this protein?
Alpha-galactosidase, Alpha-D-galactoside galactohydrolase, Melibiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
Protein: SYE_PSEE4
Sequence: MTTVRTRIAPSPTGDPHVGTAYIALFNYCFAKQHGGEFILRIEDTDQLRSTRESEQQIFDALRWLGIEWNEGPDVGGSHGPYRQSERGEIYAKYAKELVDAGHAFYCFCTAEELEQMRAEQMARGETPRYDGRALLLSDEEVQRRLAAGEPHVIRMKVPSEGICVVPDMLRGDVEIPWDRMDMQVLMKNDGLPTYFLANVVDDHLMGITHVLRGEEWLPSAPKLIKLYEYFGWEQPKLCYMPLLRNPDKSKLSKRKNPTSVTFYERMGFMPEAMLNYLGRMGWSMPDEREKFSLAEMVEHFDLSRISLGGPIFDIEKLSWLNGQWLRELPVEEFAARVQKWAFNSDYMMKIAPHVQGRVETFSQVAPLGGFFFEGALKLDAKLFESKKLSADQVRQVMQLILWKLESLRQWEKDRITGCIQAVVESLELKLRDAMPLMFAAITGQASSVSVLDAMEILGPDLTRYRLRQAIDLLGGVSKKENKEWEKLLASIA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_ECO45
Sequence: MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine (PubMed:31950558).  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation (By similarity).  Part of a bifunctional DHAP-shunt salvage pathway for SAM by-products (PubMed:31950558).
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: ATPG_SPHAL
Sequence: MASLKELKGRIVSVKSTQKITKAKKMVAAAKLRKAQAAAEAARPYAERLEGVVASLASKVGASDSAPKLLSGTGKSDTHLLVVLNSDRGLAGAFNSNIVKAARDKALELQSQGKKVLFYLVGRKGRPVIARLFPGQIIEQYDTTGIRDIGFDQASEISARVMELYEAGAFDVAHLFYSKFRSALLQIATGQQMIPVPPPAEAPASSGAAVEYEPGEEEILADLLPRNVTIQIFKGLLENAASEQGASMTAMDNATRNAGELINKLTIIYNRTRQAAITTELIEIIAGAEAL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LEP2_SYNY3
Sequence: MTENIVRETSKKKESPPENTWLELGKTMVTAVILAIGIRTFVAEARYIPSSSMEPTLQINDRLIIEKISYRLRDPERGEIVVFNPTDALKAKNFHDAFIKRIIGLPGDEVRVSQGNVYVNGKMLDENYIAAPPAYEYGPVKVPDDQYLVLGDNRNNSYDSHYWGFVPREKLLGRAFVRFWPVPRVGLLTDDAEREAVEISPQAWESPAISPQTVPESR
What are the official names of this protein?
Probable signal peptidase I-2, SPase I-2, Leader peptidase I-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: RS25_ENCCU
Sequence: MVKKIQESKEKKALKAASGTRKDKKKWGDGRKKEEVRRAVTVSEELLAKVRKDVGRASVVTRYMIGSRYNLNLGVAENVLRHLSNEGVVQQVLGNRRMTIYAGCRAQEQ
What are the official names of this protein?
40S ribosomal protein S25.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS25 family.
Protein: RL9_CITK8
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNVEFFEARRAELEAKLADVLAAANARAEKINALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTTGEHEVNFQVHSEVFAKLTVNVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: CH10_MACCJ
Sequence: MLKPYGNRVVIQKTERETTTASGIVLTDSAKEKTNEGTVVAVGTGRILNNGERVEIGVSVGDRVVYEPFGGTEVKTGDESYIVLKEEDIIAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATE_SULIK
Sequence: MSELNYEELGLKVGLEIHQQLNTSHKLFCNCSTNLKEDYKLTLERYLRPALSELGEVDVAALFEWKKGKKYVYRIPITTSCLVEADEEPPHAINEEALKIALAIAIALNSNIVDEIYVMRKIVIDGSNTTGFQRTAIVALGGMLKDEGVTIQTIAVEEDAARKIDERTDQVTYSLDRLGIPLIEISTGPDIRSPEQAERVALKIGQLLRMTGKVKRGIGTIRQDLNISIKGGTKIEIKGVQKLELIPDIVRYEAMRQFNLLKIKEELNKRGVSKNLILSNFVVKDLTELFKNTNSKIIKSGIEKGGLVYGIRAYKLKGILGWELIPKKRRFGTEIADYVRALAELGGLFHSDELPNYGITEEEINKVREALNATTEDGFILIVGERERLDKAVEVIRDRILLAFDGIPKETRGALDDGTTKFLRPQPSSARMYPETDIPPRRIDEKLLEDAKKFVPESPESKMKRYITLGLSEELAKEIIRDPRLDLFEELVNKYSPKVSPVVIASTITNTLKYVKSKGGDISKINEEDIEELIKSVYENKISKDSISEILLEYTTNKNVELKDVIRKYEALPTEELEKIIDDVISSNLDEIRKRKDKAVNLIMSKVMSKVKGRAEGKVILELIKSRLKNVME
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit E, Glu-ADT subunit E.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatE subfamily.
Protein: CH10_COLMA
Sequence: MSIRPLHDRVIVKRKDAESKSEGGIVLMGSATEKSTRAEVIAVGNGRILENGEVRPLDVKVGDQVIFSEGYGVKTEKIDGEEVLILSESDILAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRYP_PENMO
Sequence: IVGGTAVTPGEFPYQLSFQDSIEGVESHFCGG
What is the function of this protein?
High efficiency toward native protein substrates including collagens.
What are the official names of this protein?
Trypsin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: NUOA_COXBU
Sequence: MLVLANYFPILVFLGISLFIAVLALTMGWFFGPRRPDKAKLSPYECGFEAFQDARLPFDVRFYLVAILFIIFDLETAFLFPWAVVLRHIGWFGFWAMMVFLAILVVGFIYEWKRGALEWE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LON_FERNB
Sequence: MPNKNDNKGKYSRLEKEAKKAREEKISIPNVLPAIAMRSNMVIFPNTVVPFYVGREISLMALEEAMEKTNQIVFVVNQKDPAVETPTEKDLYKVGTIVRIIQVGKLPDETFKVLVEGIARAKWIKNVGEKFFKFEIEILRTRYGKSKRLIALMRMVKEELHKYVQYSRKIPPETLMLLEDVDNPDVFADIAASLCPGNIEEKQQLLEIVHPANRLERILDILARETELLEIEQQLDQKVKERIEKSQREYYLREKLRVIRDELGGEEDIEIKELKEKIENNNYPEFVKEKARAEINRLEKMSPYAPEATVVRTYLDWILNLPWHEKTDDTDDINFAEKVLNEDHYGLDEPKRRILEYLATRKVSQKAKAPIICFVGPPGVGKTSLAKSIARAMNRKFGRMSLGGLRDEAEIRGHRRTYVGAMPGRIMQLIRKLGVKNPVILLDEIDKMGISFQGDPASALLEVLDPEQNKEFVDHYIELPYDLSEVLFVTTANVLYTIPPALRDRMEVIEISSYTDVEKFYIAKNYIIPKIESEFVEKADEIFSFKDTAIKKIINEYTLEPGVRELEREIRSVVRKATLDAIKTGKKIVISPEKVTEYLGPSKIKDEDKLEKPMIGVTTGLAWTPNGGTTLYIESTLIPGNGGLIITGQLGDVMKESVRIALSLARKIVGDEYAEKFTKNDIHVHVPEGAVPKDGPSAGVTITTALVSVVKNIPVRNDIAMTGEITLRGRVLPVGGIKEKVMAAYRKGIYHVILPKKNEVDIEKVPEVVRTKMKFTFVETIEEVLEVALNEDNSKESRKGRTRKGNSNTK
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_ECOL6
Sequence: MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQVMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSQELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ARHG2_RAT
Sequence: MSRIESLTRARIDRSKEQATKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLRNNTALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGSRRGLSSLSLAKSVSTTNIAGHFNDESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSWSLAVDSSFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPVLINRILQNSHGIEEEYQDLAAALGLVKELLSNVDQDVHELEKEARLQEIYNRMDPRAQTPVPGKGPFGRDELLRRKLIHDGCLLWKTATGRFKDVLLLLMTDVLVFLQEKDQKYIFTSLDKPSVVSLQNLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRLCPSREDFPLIETEDKAYLRRIKTKLQQKNQALVELLQMNVELFAEMVHFQALKAGFIGMPPPTLPRGLFRLESFESLRGERLLKDALREVEGLKDLLLGPCVDLPLTAREPALPVEADSGSCPGVTANGEARTFNGSIELCRADSDSSQKDRNGNQLRSPQEEALQPLVNLYGLLQGLQAVVVQQERLMEALFPEGPERWEKLSRANSRDGEAGRAAVASVTPEKQATELALLQRQHSLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIRRQLAALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPVTVRSLHRPFDDREAQELGSPEDRLQDSSDPDTCSEEEVSSRLSPPHSPRDFTRMQDIPEETESRDGEPTASES
What is the function of this protein?
Activates Rho-GTPases by promoting the exchange of GDP for GTP.  May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer.  Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases.  May stimulate instead the cortical activity of Rac.  Inactive toward CDC42, TC10, or Ras-GTPases.  Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens.  Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase.  Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.  Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability.  Involved in neuronal progenitor cell division and differentiation.  Involved in the migration of precerebellar neurons.
What are the official names of this protein?
Rho guanine nucleotide exchange factor 2, Guanine nucleotide exchange factor H1, GEF-H1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton.