PharMolix/UniProtQA huggingface dataset:
Protein: LPXB_NEIMA
Sequence: MADKKSPLIAVSVGEASGDLLGAHLIRAIRKRCPQARFVGIGGELMKAEGFESLYDQERLAVRGFVEVVRRLPEILRIRRGLVRDLLSLKPDVFVGIDAPDFNLGVAERLKRSGIPTVHYVSPSVWAWRRERVGKIVHQVNRVLCLFPMEPQLYLDAGGRAEFVGHPMAQLMPLEDDRETARKTLGVDAGIPVFALLPGSRVSEIDYMAPVFFQTALLLLKRYPAARFLLPAATEATKRRLAEILQRSEFAGLPLTVTDRQSETVCRAADAVLVTSGTATLEVALCKRPMVISYKISPLTYAYVKRKIKVPHVGLPNILLGKEAVPELLQHDAVPEKLAAALADWYEHPDKVAALQQDFRVLHLLLKKDTADLAARAVLEEAGC
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: YA0C_SCHPO
Sequence: MSRISLSNFLSLPRYKFLLFSVVLIIVMTTLVFNGHDYKQTLNDRLTSLKNNFVEENDNAVLKEEPGKYTYMSLFTMPSTEEDYYFNATRVLIHRLKYHPTTKSKYPIHILALRGVDEWKIERFRKDGASVIVIDPIASSDIVYDTSSFSQEISARYEQMFSKLRIFEQIQFDKICVIDSDILIMKNIDDIFDTPYMYQQINTLNYTRLPSYTKPDDDTVYHFNEDFKEYGASRSEFYPYLLAAVSDRGEHHSIPPEDTPYFNAGLMLIRPSELHFNRILKIGRFPYMYENAKMMEQSLLNLAFSLDGWFPWTRLDPYYNGVWPSIDERPLLKTAHGKFWNIGSSEFAPVYLADWYAAYGEMLSFHKYETH
What are the official names of this protein?
Uncharacterized protein C5H10.12c.
What is the protein family that this protein belongs to?
To S.pombe SpBC4C3.08 and SpBC4C3.09.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ACPS_LEPBL
Sequence: MKISVGNDIVENARIRDLLEKHGDRFLKRIFSESEREYCSNRKDPVPHLSGRFCVKEAFIKAIEPKVVLDMREIELFGKEFGKKELVLHGKSKELFLTKGYNGCSVSISHAENYSTAVVVLYKE
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1079_STRA5
Sequence: MPFVKIDLFEGRSQEQKNELAREVTEVVSRIAKAPKENIHVFINDMPEGTYYPQGELKKK
What are the official names of this protein?
Probable tautomerase SAG1079.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family.
Protein: GXM1_ARATH
Sequence: MRPKANQNHKLKVLLVFLLATLILIFIVRSTLTSSQEHQTPQETRSTRCSGACNKLPRSLAQALIHYSTSVITPQQTLKEIAVSSRVLGKKSPCNFLVFGLGHDSLMWSSLNYGGRTVFLEEDEAWIKQIKRRFPMLESYHVTYDSKVNQADNLIEVGKGPECTAIGDPRYSMCQLALKGLPAEIYETGWDLIMVDAPTGYYDEAPGRMTAIYTAGMMARNRKQGGETDVFVHDVNREIEDKFSKAFLCEGYMKKQEGRLRHFIIPSYRDGSESESNRPFCP
What is the function of this protein?
Methyltransferase catalyzing 4-O-methylation of glucuronic acid side chains on xylan.
What are the official names of this protein?
Glucuronoxylan 4-O-methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass membrane protein.
Protein: RS2_SINMW
Sequence: MALPDFTMRQLLEAGVHFGHQTHRWNPKMKPYIFGDRNNVHIIDLAQTVPMLSRALQVVSDTVASGGRVLFVGTKRQASEIIADAAKRSAQYYVNARWLGGMMTNWKTISNSIQRLRKLDEILASEASGFTKKERLNLEREREKLNRALGGIRDMGGTPDLMFIIDTNKESIAIEEAKRLGIPVVAVIDSNCDPDQIDYPIPGNDDASRAVALYCDLIARAAIDGIARQQGASGRDLGASEEVPVEPALEEASEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SEPT2_PONAB
Sequence: MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERVIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKRGGRKVENEDMNKDQILLEKEAELRRMQEMIARMQAQMQMQMQGGDGDGGSLGHHV
What is the function of this protein?
Filament-forming cytoskeletal GTPase.  Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity).  Required for normal organization of the actin cytoskeleton.  Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin.  Required for the progression through mitosis.  Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression.  During anaphase, may be required for chromosome segregation and spindle elongation.  Plays a role in ciliogenesis and collective cell movements.  In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein (By similarity).
What are the official names of this protein?
Septin-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane. Cell projection, cilium, flagellum. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. Found in the sperm annulus (By similarity).
Protein: RS6_GRAFK
Sequence: MNNYETVFILNPVLSDEQIKETVKKYEDFLVSKGAEMVAKEDWGLRKLAYAIQHKKSGFYHLFEYKAPGDAIEPLELEFRREERMMRYLTVKLDKHAIAWAEKRRKRNKEKA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: SKOR_ARATH
Sequence: MGGSSGGGVSYRSGGESDVELEDYEVDDFRDGIVESRGNRFNPLTNFLGLDFAGGSGGKFTVINGIRDISRGSIVHPDNRWYKAWTMFILIWALYSSFFTPLEFGFFRGLPENLFILDIAGQIAFLVDIVLTFFVAYRDSRTYRMIYKRSSIALRYLKSTFIIDLLACMPWDIIYKAAGEKEEVRYLLLIRLYRVHRVILFFHKMEKDIRINYLFTRIVKLIFVELYCTHTAACIFYYLATTLPASQEGYTWIGSLKLGDYSYSKFREIDLWTRYTTSMYFAVVTMATVGYGDIHAVNMREMIFAMVYISFDMILGAYLIGNMTALIVKGSKTERFRDKMADIMRYMNRNKLGRNIRGQITGHLRLQYESSYTEAAVLQDIPVSIRAKIAQTLYLPYIEKVPLFRGCSSEFINQIVIRLHEEFFLPGEVIMEQGSVVDQLYFVCHGVLEEIGITKDGSEEIVAVLQPDHSFGEISILCNIPQPYTVRVAELCRILRLDKQSFMNILEIFFHDGRRILNNLLEGKESNVRIKQLESDITFHISKQEAELALKLNSAAFYGDLYQLKSLIRAGGDPNKTDYDGRSPLHLAASRGYEDITLYLIQESVDVNIKDKLGSTPLLEAIKNGNDRVAALLVKEGATLNIENAGTFLCTVVAKGDSDFLKRLLSNGIDPNSKDYDHRTPLHVAASEGFYVLAIQLVEASANVLAKDRWGNTPLDEALGCGNKMLIKLLEDAKNSQISSFPSGSKEPKDKVYKKKCTVYFSHPGDSKEKRRRGIVLWVPRSIEELIRTAKEQLNVPEASCVLSEDEAKIIDVDLISDGQKLYLAVET
What is the function of this protein?
Highly selective outward-rectifying potassium channel.  Involved in potassium release into the xylem sap toward the shoots.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by depolarization.  The voltage-dependence of the channel is abolished by internal or external acidification.  May interact with the cytoskeleton or with regulatory proteins.
What are the official names of this protein?
Potassium channel SKOR, Stelar K(+) outward rectifying channel.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: QACR_STAHA
Sequence: MNLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQEQWKKEQIKCKTNREKFYLYNELSLTTEYYYPLQNAIIEFYTEYYKTNSINEKMNKLENKYIDAYHVIFKEGNLNGEWCINDVNAVSKIAANAVNGIVTFTHEQNINERIKLMNKFSQIFLNGLSK
What is the function of this protein?
Transcriptional repressor of qacA.  Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site.  QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator QacR.
Protein: GATB_SYNP2
Sequence: MAVAAPRKTEYEAIIGLETHCQLNTASKIFCHCSTKFDSDPNSNVCPVCLGYPGVLPVLNEKVLESAVKMGLALKAKISPYSKFDRKQYFYPDLPKNYQISQFDLPIVEHGHLEIEIADKPSDPPVKKTIGVTRLHMEEDAGKLVHAGSDRLAGSTYSKVDFNRTGIPLLEIVSEPDIRSGKEAAEYAQELRRLVRYLGIGDGNMQEGSLRCDVNISIRPVGQEEFGTKVEIKNMNSFSAIQKAIDYEIERQIKAVETGEPIYQETRLWDESSQRTFSMRKKEGSSDYRYFPEPDLPPIEVTPAQLEKWAAELPETPAQKRERYETEYGLSSYDTRVLTDDRDVAEYFEAAVAAGADPKQVTNWVTQDIAAHLNKNVGLTIVELPLKATQLAELVNLIHDGTISGKIAKEILPELLEQGGSPKAIVESRGLTQISDTGALEAMVDEVLAANPEKVEQFRAGKTKLQGFFVGQLMKKTSGRADPKLLNQILAQKLRG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: GLYA_BACC1
Sequence: MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRVKEIFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDAESHRINYDDVLAKAKEHKPKLIVAGASAYPRVIDFKRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEEQFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIINNANRLAEGLQKEGLTLVSGGTDNHLILIDVRNLEITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGTAAVTSRGFGLEEMDEIASLIAYTLKNHENEAALEEARKRVEALTSKFPMYTDL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_COREF
Sequence: MNDSPVLVVGLGNPGPKYVGTRHNIGFEVVEELVGRNYANFSVHKRSNTEIAQLPGLIVAKPRSFMNLSGTPIRALCDFFKISPANVLVVHDELDLDFGQVKLRQGGGDHGHNGLKSTSRSLGTKDYWKLSVGIGRPPGRMDPATFVLKPFSKQEQDSVPIMAADAADLIEEHIRTL
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEE_METKA
Sequence: MGTGGRGRPTPGLNVYEVFLSLQGEGKFVGEPQAFVRFSGCNLRCAYCDEPASRSSRRRALIRRVSGEVELELPVPCGPEDVVEVLVELEDLEDTFGTVSLTGGEPLVQPWGALKELIERLRERGFRVLLETNASLPDRAPLIDELADVVSADVKLPSHGPNMDDFPDRCLRFLERISAEVYAKVVLVDEECYQHAESALKGLHRLGVEPIYLQPATGSEHDLEDLWELAGLVNADVRVLPQVHKLVDFIPR
What is the function of this protein?
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
What are the official names of this protein?
7-carboxy-7-deazaguanine synthase, CDG synthase, Archaeosine biosynthesis protein QueE.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
Protein: DNAJ_RUTMC
Sequence: MSQKDYYEILGVAKNADAKQIKKAYKRLAMKHHPDRVKNDKASAEKKFKEIQKAYAILSDVQKRQAYDQFGHVGGNANVGSAGGNPFGGGFGDIFGDIFGGGSQQSNNRGSDLRYDLEIDLKKAAQGSTVKIRIPKNETCDTCSGIGAKSGTNVKTCSICSGVGQVQTQQGFFTVQRPCGTCSGTGQKIEFPCGTCRGQGLVRKQKTLSVKIPAGVDTGNRIRLSGEGEAGTIGSSSGDLYVQVHVKKHAIFEREDNDLYCEVPIDFATAALGGSIEVPTLENKLKIKVPSGTQTGKLFRLRDKGISHLQRDGSGDLICQVKIETPVNLNKKQQDLLQKFSSSCGKKHHPESDSFFDKMKSFFG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMF_CROS8
Sequence: MAQFGSVCLPEAFLDVMREAMPAGLAMDDFIAACQRPLRRSIRVNTLKISVDAFLAQVAPYGWQLTPVPWCPEGFWIERDDEDALPLGSTAEHLSGQFYIQEASSMLPVAALFADGNTPARVMDVAAAPGSKTTQIAALMQNQGFILANEYSASRVKVLHANISRCGIHNVGLTHFDGRVFGAALPEQFDAILLDAPCSGEGVVRKDPDALRNWSPQSDQEIAATQRELIDSAFHALAPGGTLVYSTCTLNREENQETVRWLLARYPQAVEVLSLEALFPGADAALTEEGFLHVFPQIYDCEGFFVARLRKTASVEPLPAPTYKVGAFPFTPLKTREAQAVIAAARKVGLEWDETLELWQRDKEIWLFPQAFTPFIGKVRFSRTGIRLAEIHNKGYRWQHEAVVALAGSDNPLGFELSAEEAQEWYRGRDVWPQTVPDADDVIVTFQHQPLGLAKKVGSRLKNSYPRELVRDGVLFSAPV
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGC_NOCFA
Sequence: MRSQPHVLGIVLAGGEGKRLFPLTADRAKPAVPFGGAYRLIDFVLSNLVNAGYLRLCVLTQYKSHSLDRHISQTWRLSGFAGEYITPVPAQQRLGPRWYTGSADAIMQSLNLIYDEDPDYIVVFGADHVYRMDPEQMVSHHIDSGAGVTVAGIRVPRSEASAFGCIDSDESGRITQFLEKPAHPPGTPDDPNMTFASMGNYVFTTKVLVDSIRADAENSDSDHDMGGDIIPALVEAGEAGVYDFADNQVPGATDRDHGYWRDVGTIDAFYDAHMDLVSVHPVFNLYNKHWPIRGAAENLPPAKFAQGGLAQECIVGSGSILSAATVRNSVLSSNVVVDDGATVEGSVLMPGVRIGRGAVVRRAILDKNVVVGEGEIIGVDLDRDRERFAVSNGGVVTVGKGVWV
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: RL24_GILMI
Sequence: MKVELCSFSGYKIYPGHGRRYARIDGKVFQFLNAKCESAFLAKRNPRQINWTVLYRRKHKKGQSEEVTKKRTRRAVKFQRAITGASLAEIMAKRNQKPEVRKAQREQAIRAAKESKKAKQATKKPAAASAKTSAKTAQKPKIAKPMKISAPRVGGKR
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_RICB8
Sequence: MKNKIKIRLKSFDHRSLDQATKEIVSAVKRTFANISGPIPLPRKIQRFTVNRSPHVHIKSREQYEIRTQKRLLVIDDPNPVVVDALSKVDLAAGVDVVIELESGE
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RECX_ECOLI
Sequence: MTESTSRRPAYARLLDRAVRILAVRDHSEQELRRKLAAPIMGKNGPEEIDATAEDYERVIAWCHEHGYLDDSRFVARFIASRSRKGYGPARIRQELNQKGISREATEKAMRECDIDWCALARDQATRKYGEPLPTVFSEKVKIQRFLLYRGYLMEDIQEIWRNFAD
What is the function of this protein?
Modulates RecA activity through direct physical interaction.  Can inhibit both RecA recombinase and coprotease activities.  May have a regulatory role during the SOS response.  Inhibits DNA strand exchange in vitro.
What are the official names of this protein?
Regulatory protein RecX, Protein OraA.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HNRPL_HUMAN
Sequence: MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS
What is the function of this protein?
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion.  Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023).  Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284).  Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).  As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein L, hnRNP L.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules.
Protein: RIPLY_SILCH
Sequence: RPSWTVDSDSAKYSSFLDSLREEFGRGTPKVCNIPVTKKANNDKFVLVNLVLPFNRNTITLAFRASDAYLVGFQDRDSKTNKLRANFFSDEYRALSGKYKSIFTDAEVLAPALPCASTYTDLQNKAGVSREKLSLGVSSLQTAFTAVYGKVFTGKNVAKFALISIQMVAEAARFKYIEDQVINRGMYSSFEAGARITLLENNWSKISEQYHKSCKLGGGQFTEEEMKLGLLLYN
What is the function of this protein?
Ribosome-inactivating protein of type 1, inhibits protein synthesis in animal cells.  Inhibits cell-free translation in rabbit reticulocyte lysate system with an IC(50) of 0. 17 nM.
What are the official names of this protein?
Ribosome-inactivating protein lychnin.
What is the protein family that this protein belongs to?
Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.
Protein: EGR1_MOUSE
Sequence: MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGGNSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKAMVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSSSASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPATKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQDLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASPAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGFPSPSVATTFASVPPAFPTQVSSFPSAGVSSSFSTSTGLSDMTATFSPRTIEIC
What is the function of this protein?
Transcriptional regulator (PubMed:8336701, PubMed:8703054, PubMed:15958557).  Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:8703054, PubMed:15958557, PubMed:2028256, PubMed:8939742).  Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity).  Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia (PubMed:11100120, PubMed:15958557).  Plays a role in the regulation of cell survival, proliferation and cell death (PubMed:15265859, PubMed:15958557).  Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation (PubMed:15958557).  Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy (PubMed:15265859).  Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia (PubMed:11100120).  Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (PubMed:8703054).  Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription (PubMed:26471974).  Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (PubMed:29138967).
What are the official names of this protein?
Early growth response protein 1, EGR-1, Nerve growth factor-induced protein A, NGFI-A, Transcription factor Zif268, Zinc finger protein Krox-24.
What is the protein family that this protein belongs to?
Belongs to the EGR C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: EFTU_PROMS
Sequence: MAREKFERNKPHVNIGTIGHVDHGKTTLTAAITNVLAKKGQAQAQDYGDIDGAPEERERGITINTAHVEYETEGRHYAHVDCPGHADYVKNMITGAAQMDGAILVCAATDGPMAQTKEHILLAKQVGVPALVVALNKCDMVDDEEIIELVEMEIRELLDSYDFPGDDIPIVQVSGLKALEGDTTWESKIEELMKAVDASIPEPEREVDKPFLMAVEDVFSITGRGTVATGRIERGKVKVGEEVEIVGIRDTRVTTVTGVEMFRKLLDEGMAGDNVGLLLRGVQKEDIERGMVLVKKGSITPHTQFEGEVYVLKKEEGGRHTPFFAGYRPQFYIRTTDVTGQITAFTSDDGSNVEMVMPGDRIKMTGELICPVAIEQGMRFAIREGGRTIGAGVVSKILK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.