PharMolix/UniProtQA huggingface dataset:
Protein: MECA_STRZJ
Sequence: MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKIDQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFAKLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLNLQKIG
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: MUTS_DECAR
Sequence: MVKDKAPDLSKHTPMMRQYLALKANHPNTLLFYRMGDFYELFHEDAEKAARLLDITLTTRGQSAGVPIKMCGIPFHSLEPYLARLVKLGESAVICEQIGDPATSKGPVERAVARIVTPGTLTDAALIDDKQDLWLLAVTTHRNTAGIARLNLASGEFILIEVPTEQIPATLERIRPAEILYPESWTPNFGVDVARTRQPDWYFEFDSARRLLCDQFEVASLAGFGAEGLKPAIAAAGALLQYAQATQSGKLPHLRGLTVEIEGAYLGLDLATRRNLELTETLRGQPSPTLFSLLDNCVTSMGSRLLRHTLHHPLRARDIPAARHGAVEALLEDYGRLGNEVRKALRGIADIERIAGRVALRNARPRDLASLRESVARLEGLRAPLSDSPAPLIAQLFTELETPYPALELLVRAIAAEPGAQVRDGGVIAPGYDPDLDELRSLNDNCGAFLVDMEARERERSGIASLKVEYNKVHGFYIEVTHANVDKIPDDYRRRQTLKNAERYITPELKAFEDKALSAQERSLAREKLLYEAILDALLPVVPTLQTIARAIAQLDLLAGFAESALKRNWCKPEFAAETQLSITGGRHPVVEGELTNQAETFIANDCLLAENRRLLLITGPNMGGKSTYMRQVALIALLAHIGCYVPADRCVLGPLDRIFTRIGASDDLASGRSTFMVEMTEAAAILHHATNQSLVLMDEIGRGTSTFDGMALAFAILRHLIEKNQSLTLFATHYFELTRLSHEYSELANVHLGAVEHNDRIVFMHAVEEGPANQSYGIQVAALAGIPTAVVRAARKQLREFEQRAAVDPLQPDLFAQGAPEPAEPEPHPVVEQLAAIDPDSLTPREALDALYALKGLLR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: AROK_SHEPC
Sequence: MAEKRNIFLVGPMGAGKSTIGRHLAQMLHLEFHDSDQEIEQRTGADIAWVFDVEGEEGFRRREAQVIADLSEKQGIVLATGGGSVQSKDIRNHLSARGIVVYLETTIDKQVARTQRDKRRPLLQVDDPREVLESLAEIRNPLYEEIADVIVKTDDQSAKIVANQIIEKLGF
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YF4B_SCHPO
Sequence: MAEFDDSCLPTNPTTENDYHGSFPYCSVHAQLYPYVSDCMVMHRKAPINEQEALRDVVWETRTINKKLHVTPIKPNITSILLVSKPGDEEVEEKLKEFVYWLISLDNITVFIQKSMEDLFEKTEKIQYWTTLLCTKHSQLFDLVLTLGGDGTVLYTSRLFQRTVPPIMPFAMGTLGFLTHFDVKKYKTSILEICNEMYVHLRTRFECRVMKKKNRTQWINIDEHLSQSLHATDTETHTFTDSLVVLNEVVIDRGPNTAMSDIMLYVDSKYLTTVKADGLCISTPTGSTAYSLAAGGSLCHPDISVMIVSPICAHSLSLRPIHVPDSMALHVVIPQDAQQSSWISFDGRNRTELLPGDYLTVRISRYPFPTVHSTEEDADWFESIKRTLMWNQN
What are the official names of this protein?
Uncharacterized kinase C3H5.11.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RPO6_THEGJ
Sequence: MFRYTRFEKARIIGARALQIALGAPVLVDVPEGSTPLQAAIIEFEKGIIPITVIRPS
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo6, DNA-directed RNA polymerase subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_PSEAB
Sequence: MLTHLDSQGRANMVDVTEKAVTSREATAEAVVRMRPETLQLIQDGGHPKGDVFAVARIAGIQAAKRTHELIPLCHPLLLTSVKLELQAEAPDAVRIRARCRLAGQTGVEMEALTAASVAALTIYDMCKAVDRGMVIEQVQLLEKLGGKSGHYRKEEEGQA
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: UPPH_NEOYE
Sequence: MQLQINIASHPLIQHWSGILKNDNNPGTILRTACSELGKWITYEIMREWLVTETIELKANTTISLISSHYKYIIVIIMPYGFILAEGARSLLPTANIVLVNYNDIINNVPDQLNSFTKILVLDLFLDEATITPLLNDFIKKGAVLSNIKIACLECGTSQLNQLGQIWSKLEIYTTKVNTNVDKEKCSREDDFKDKFFV
What are the official names of this protein?
Uracil phosphoribosyltransferase homolog.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LIS1_PARBP
Sequence: MSQLLTARQAEELHKAMIAYLLSANLPKSAAALREELADSVQLDDSTAKKYEGLLEKKWTSVVRLQKKIMDLESRNNALQSELDSATPTSLARRNQDPVSWLPHAPARHILQSHREPVTCVGFHPVFSSLASGSDDTTIKIWDWELGELERTIKGHTKAVLDVDYGGPRGGTLLASCSSDLTIKLWDPSDGYKNIRTLPGHDHSVSAVRFIPSGAAGSPLSGNLLVSASRDKTLRIWDVTTGYCVKTLRGHVDWVRDVVASPDGRFLFSAGNDQVARLWDVSSGETKSTFLGHEHAVECVAFAPPTSYPHLAALAGLKKAPPSSSSAEYVATGSRDKSIRIWDARGTLIKTLIGHDNWVRALAFHPGGKYLLSVSDDKTLRCWDLTQECKCVRTVKDAHGHFISCIRWAPNIIKDAGVVNGDDTSTAASANGGALGASAINGVVPTGKKEDPGGGPMMGIRCVIATGSVDLKVRVFAS
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein PAC1, Lissencephaly-1 homolog, LIS-1, nudF homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Protein: P2C47_ORYSJ
Sequence: MVAEAEVMHQPVPVLEVPYHRCVAKGVEEVAAAAAVAPPPVVEVEVAVQVPHMGLESAAGAPSISVDALQFVPSIRSGSFADIGPRRYMEDEHIRIDDLSAHLGSLLVCPLPSAFYGVFDGHGGLDAAAYMKRHAMRFLFEDSEFPQASQVDETYVQSVENSVRRAFLQADLALADDLDISRSSGTTALTALVFGRQLLVANAGDCRAVLCRRGVAMEMSRDHRANYAEECERVAASGGYIEDGYLNGVLSVTRALGDWDMKMPDGSISPLIAEPEFRQTMLTEDDEFLIMGCDGIWDVMTSQHAVSIVRRGLRQHDDPERCARELVMEAKRLETADNLTVIVVCFVSELGSPRQEQVGGQAGVARPRSCKSLSAEALCNLRSWLETDR
What are the official names of this protein?
Probable protein phosphatase 2C 47, OsPP2C47.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: RL22_STRZJ
Sequence: MAEITSAKAMARTVRVSPRKSRLVLDNIRGKSVADAIAILTFTPNKAAEIILKVLNSAVANAENNFGLDKANLVVSEAFANEGPTMKRFRPRAKGSASPINKRTAHITVAVAEK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: NADK_STRZP
Sequence: MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIVISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGARVSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVSTPTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRNDYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_ECOLC
Sequence: MTILNHTLGFPRVGLRRELKKAQESYWAGNSTREELLTVGRELRARHWDQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNVPPRHQNKDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYMVPEFVKGQQFKLTWTQLLEEVDEALALGHNVKPVLLGPVTYLWLGKVKGEQFDRLSLLNDILPVYQQVLAELAKRGIEWVQIDEPALVLELPQAWLDAYKPAYDALQGQVKLLLTTYFEGVTPNLDTITALPVQGLHVDLVHGKDDVVELHKRLPSDWLLSAGLINGRNVWRADLTEKYAQIKDIVGKRDLWVASSCSLLHSPIDLSVETRLDAEVKSWFAFALQKCHELALLRDALNSGDTAALAEWSAPIQARRNSTRVHNPAVEKRLAAITAQDSQRANVYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRTLRLDFKKGNLDANNYRTGIAEHIRQAIVEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPIVIGDVSRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVSRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLQWGVEAFRINAAVAKDDTQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEEFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAKRIPAERLWVNPDCGLKTRGWPETRAALANMVQAAQNLRRG
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: RS3A_CRYNB
Sequence: MAVGKNKRLSKGKKGIKKKVVDPFTRKEWYDIKAPSFFENRNAGKTLVNRTQGLKNANDSLKGRVLELSLADLNNDQEQSFRKIKLRVEDVAGKSCLTSFYGMDFTTDKLRSIVRKWQSLVEAHVDVKTTDGYVLRLFAIGFTKRQSNQVKKTTYAQSSQLKEIRAKMVEIMRREAEGSDLKELVQKFVPESIGREIEKAAKGIYPLHNVYVRKAKIVKTPKIDMSKLLESHGEAMDANTGSKVVKSGEFVEPEILESV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDH3B_BOVIN
Sequence: MAALSRVRWLTRALVAAPNPGAWRSLCTSTVAQASSRTQGEDVRVEGAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFEKMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEHHSNMIAEAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLHPYGG
What is the function of this protein?
Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate.  The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
What are the official names of this protein?
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial, Isocitric dehydrogenase subunit beta, NAD(+)-isocitrate dehydrogenase subunit 1, IDH1, NAD(+)-specific ICDH subunit beta.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MURD_HELPG
Sequence: MKISLLGHGKTTLALARFFKKNHNEVKFFDDQFTAFHKDEEGFLCYPSKDFNPNDSQLEVVSPGISFMHPLVIKAKHLVSEYDYINSLFDLVFTPTIISISGTNGKTTTTEMLTALLEDFKAVSGGNIGTPLIELFEKQSPLWVLETSSFSLHYTNKAYPLIYLLINVEADHLTWHCNFENYLNAKLKVLTLMPKTSLAILPLKFKEHPIIQNSQAQKIFFDHSEEVLERLKIPSNALFFKGAFLLDAALALLVYEQFLKIKNLKWQDYRENALKRLNAFKIGSHKMEEFRDKEGRLWVDDSKATNIDATLQALKTFKNQKIHLILGGDIKGVNLTPLFEEFKNYKISLYAIGSSASIIQALALEFNISCQVCLKLEKAVQEIKSVLLQNEIALLSPSAASLDQFSSYKERGEKFKAFVLKD
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_FLAPJ
Sequence: MNIHEYQGKEILASYGVRIQRGIVANNPVEAVAAAKQLTTETGTSWYVVKAQVHAGGRGKGGGVKLAKNLQQVEEISEQIIGMQLITPQTSAEGKKVHKVLIAEDVYYPGESETSEFYISVLLNRSTGRNMIVYSTEGGMDIEEVAAHTPHLIHNEEIDPSVGLQAFQARRIAFNLGLSGNAFKEMVKFIDSLYNAYIGSDASMFEINPVLKTSDDKIMAVDAKVNIDDNALYRQPKYADMRDIREENPIEVEAKEVGLNYVDLDGTVGCMVNGAGLAMATMDLIKYAGFEPANFLDVGGTADAKRVETAFRIILKDENVKAILINIFGGIVRCDRVAQGVVDAYKNMGDAIKVPIIVRLQGTNAEIAKELIDNSGMPILSAVQFQEAADQVKAALSK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RF2_RICBR
Sequence: MRAEIENYVKKIEQSLELLRRSLDVETSAARLAELEELAASPDLWNDQANAQKLLREKSNLEEQLGAYNKIRSNLKDALELEEMAEAENDLEIMQQVEKDLQSLSTIAAKFETECLFSGEADSNNCFLEINAGAGGTESHDWASIMMRMYLRFAERLGFKTEIINMINGEEAGIKSCTIRIIGRRAYGWLKTEAGVHRLVRISPFNAAGKRMTSFASSWVYPEIDDNIAITIEDKDLRIDTFRASGAGGQHVNTTDSAVRITHIPTGTVTQCQSDRSQHKNKAQAMKMLQAKLYELEMQKRTDSVNEQNAAKTDNSWGHQIRSYVLQPYQMVKDLRTDYETSDTKGVLDGDLEEFVSASLAMNAGSKK
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYL1_RABIT
Sequence: MAPKKDVKKPAAAAAPAPAPAPAPAPAPAKPKEEKIDLSAIKIEFSKEQQDEFKEAFLLYDRTGDSKITLSQVGDVLRALGTNPTNAEVKKVLGNPSNEEMNAKKIEFEQFLPMLQAISNNKDQGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALMAGQEDSNGCINYEAFVKHIMSI
What is the function of this protein?
Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function.
What are the official names of this protein?
Myosin light chain 1/3, skeletal muscle isoform, MLC1/MLC3, MLC1F/MLC3F, Myosin light chain alkali 1/2, Myosin light chain A1/A2.
Protein: NS2_HRSVB
Sequence: MSTTNDNTTMQRLMITDMRPLSMDSIITSLTKEIITHKFIYLINNECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHGGFLECIGIKPTKHTPIIYKYDLNP
What is the function of this protein?
Plays a major role in antagonizing the type I IFN-mediated antiviral response.  Acts cooperatively with NS1 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3.  Interacts with the host cytoplasmic sensor of viral nucleic acids RIGI and prevents the interaction with its downstream partner MAVS.  Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C.  The degradasome requires an intact mitochondrial MAVS.  Induces host SOCS1 expression.  Induces activation of NF-kappa-B.  Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism promoting continued viral replication.
What are the official names of this protein?
Non-structural protein 2, NS2, Non-structural protein 1B.
What is the protein family that this protein belongs to?
Belongs to the pneumovirus non-structural protein 2 family.
What are the subcellular locations of this protein?
Host mitochondrion. Note=Most NS2 resides in the mitochondria as a heteromer with NS1.
Protein: LDH_STRE4
Sequence: MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYADCHDADLVVLTAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDILTYSTWKFSGFPKERVIGSGTSLDSARFRQALAAKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDVDEQGLVDLFISVRDAAYSIINKKGATFYGIAVALARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKTIIDEAFSKEEFASAAKN
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRX1_DICDI
Sequence: MVKPSKILEKIKKRTEPVAEPVVEEESDEEIIEQEGSEEEEEIVEEESEEEEEEVEEENKNIEENKKDQSIYTKKRVLFTSTRGIGSKYRHLMADLISLIPHSKKEDKIDDRKTLSLINETCEMKSCNYAILFDVRKGTDCFLWMAKTPLGPTVKFHITNVHTLDELQMTGNCLKGSRPFLHFDKSFDSEVHLQLIKELITQIYSTPKGHVKSKPFFDHVFSFFYQDGRIWFRNYQISDQEFKKDSLLTEIGPRMIMHIDKIFSDGFGGSVLYSNPNYVSPNNTRSDHKLSKANKYIKRKYQKGKAEERQKISFIEPSEVDTVFDN
What is the function of this protein?
Required for biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein BRX1 homolog, Brix domain-containing protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the BRX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HFQ_HAMD5
Sequence: MAKGQSLQDPFLNALRKERIPVSIYLINGIKLQGQIESFDQFVILLKSTSPSLKNTICQVIYKHAVSTVVPSRAVSSSPHHAPPLQKPEDDGS
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: NTF2_RAT
Sequence: MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNFG
What is the function of this protein?
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport.  Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport.  Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
What are the official names of this protein?
Nuclear transport factor 2, NTF-2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.
Protein: FTSW_ALCBS
Sequence: MTERMILKVDHTGIDKPLLWTAILLALAGLVMVSSASLQIAETRLGDPFYYAMRHGIYLALGLGVGAFVYYAVPLALLERLRFVMLPVALVALVMVFIPGLGRTVNGSTRWIALPGLTIQASEIVKLCFVLYLAGYVAQRKAALETEWKAFLLPLGLLGVLMLLLLLEPDFGAVVVLGITAMGMLFLSGVPTLRFLLIGLIAVALGGLVAFAEPYRVARLMTFTDPWADQFGSGYQLTQSLIAFGRGHWFGVGLGNSVQKLFYLPEAHTDFVYAVMSEELGLLGNVALIGGFILLGWRVFRIGHRLEARGLLYHAYLVYGCAFVFCSQAFINLGVNMGLLPTKGLTLPFISYGGSSLLISAVMVGLILRAGAEADHLKARGRAAR
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: RAN_CANLF
Sequence: MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL
What is the function of this protein?
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs.  Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis.  Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way.  Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport.  Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins.  RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation.  Required for normal progress through mitosis.  The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.  Acts as a negative regulator of the kinase activity of VRK1 and VRK2.  Enhances AR-mediated transactivation.
What are the official names of this protein?
GTP-binding nuclear protein Ran, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
Protein: OPHN1_PONPY
Sequence: MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPISDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRTRFFETASRKTGSSQGRLPGDES
What is the function of this protein?
Stimulates GTP hydrolysis of members of the Rho family.  Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function.  Critical for the stabilization of AMPA receptors at postsynaptic sites.  Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals.  Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity).
What are the official names of this protein?
Oligophrenin-1.
What are the subcellular locations of this protein?
Postsynapse. Presynapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm.
Protein: Y1486_STAAB
Sequence: MTEHNHDSQLEINNEEELLTLFDEEGNEVLYRKVLEFYHPEFKKEYVILAEEGAQSDEDDMIELVPMINEPDESGDGGKLVPIETDEEWDMIEEVVNTEMEE
What are the official names of this protein?
UPF0473 protein SAB1486c.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.