PharMolix/UniProtQA huggingface dataset:
Protein: ANGI_GORGO
Sequence: MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP
What is the function of this protein?
Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs).  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus.  Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA.  Angiogenin induces vascularization of normal and malignant tissues.  Angiogenic activity is regulated by interaction with RNH1 in vivo.
What are the official names of this protein?
Angiogenin, Ribonuclease 5, RNase 5.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: PB2_I54A2
Sequence: MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKINDAGSDRVMVSPLAVTWWNRNGPMTSTVHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLMVTKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKETRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMIGILPDMTPSTEMSMRGIRVSKMGVDEYSSAERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKLEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKTTKRLTVLGKDAGTLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: PQSA_PSEAE
Sequence: MSTLANLTEVLFRLDFDPDTAVYHYRGQTLSRLQCRTYILSQASQLARLLKPGDRVVLALNDSPSLACLFLACIAVGAIPAVINPKSREQALADIAADCQASLVVREADAPSLSGPLAPLTLRAAAGRPLLDDFSLDALVGPADLDWSAFHRQDPAAACFLQYTSGSTGAPKGVMHSLRNTLGFCRAFATELLALQAGDRLYSIPKMFFGYGMGNSLFFPWFSGASALLDDTWPSPERVLENLVAFRPRVLFGVPAIYASLRPQARELLSSVRLAFSAGSPLPRGEFEFWAAHGLEICDGIGATEVGHVFLANRPGQARADSTGLPLPGYECRLVDREGHTIEEAGRQGVLLVRGPGLSPGYWRASEEQQARFAGGWYRTGDLFERDESGAYRHCGREDDLFKVNGRWVVPTQVEQAICRHLPEVSEAVLVPTCRLHDGLRPTLFVTLATPLDDNQILLAQRIDQHLAEQIPSHMLPSQLHVLPALPRNDNGKLARAELRHLADTLYHDNLPEERAC
What is the function of this protein?
Catalyzes the formation of anthraniloyl-CoA, which is the priming step for entry into the Pseudomonas quinolone signal (PQS) biosynthetic pathway.  Also active on a variety of aromatic substrates, including benzoate and chloro and fluoro derivatives of anthranilate.
What are the official names of this protein?
Anthranilate--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: PPR3E_RAT
Sequence: MSHERPPRNDIPRNLSFIAALTERAYYRSQRPSLEEESEEEPGEGGTRPGARSRAHVPGRGRRARSAPAGGGGARTARSRSPDTRKRVRFPDALGLELAVVRRFRPGEPPRVPRHVQVQLQRDALRHFAPCPPRTRGLQDARIALEPALEPGFAARLQAQRICLERADAGPLGVAGSARVLDLAYEKRVSVRWSADGWRSLRESPASYAGPAPAPPRADRFAFRLPAPPVGGALLFALRYRVTGREFWDNNGGRDYALLGPEHPGGAGAAEPQGWIHFI
What is the function of this protein?
Acts as a glycogen-targeting subunit for PP1.  PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 3E.
Protein: CD59_PIG
Sequence: MGSKGGFILLWLLSILAVLCHLGHSLQCYNCINPAGSCTTAMNCSHNQDACIFVEAVPPKTYYQCWRFDECNFDFISRNLAEKKLKYNCCRKDLCNKSDATISSGKTALLVILLLVATWHFCL
What is the function of this protein?
Potent inhibitor of the complement membrane attack complex (MAC) action.  Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
What are the official names of this protein?
CD59 glycoprotein, MAC-inhibitory protein, MAC-IP, Membrane attack complex inhibition factor, MACIF, Protectin.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: RS6_DESVV
Sequence: MRKFETLLLLSPELAADAREALLTTLSGVVEREQGSMITADHWGMRDLAYPVRKQMRGYYVRLEYTAPGATVAELERIIRISDGIFKFVTVKLADAVEEVA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: FEMB_STAAR
Sequence: MKFTELTVTEFDNFVQNPSLESHYFQVKENIVTRENDGFEVVLLGIKDDNNKVIAASLFSKIPTMGSYVYYSNRGPVMDFSDLGLVDYYLKELDKYLQQHQCLYVKLDPYWLYHLYDKDIVPFEGREKNDALVNLFKSHGYEHHGFTTEYDTSSQVRWMGVLNLEGKTPETLKKTFDSQRKRNINKAINYGVKVRFLERDEFNLFLDLYRETEERAGFVSKTDDYFYNFIDTYGDKVLVPLAYIDLDEYVLKLQQELNDKENRRDQMMAKENKSDKQMKKIAELDKQIDHDQHELLNASELSKTDGPILNLASGVYFANAYEVNYFSGGSSEKYNQFMGPYMMHWFMINYCFDNGYDRYNFYGLSGDFTENSEDYGVYRFKRGFNVQIEELIGDFYKPIHKVKYWLFTTLDKLRKKLKK
What is the function of this protein?
Catalyzes the formation of the pentaglycine interpeptide bridge, which is characteristic of the S. aureus peptidoglycan.  Adds glycines 4 and 5 of the pentaglycine bridge, using glycyl-tRNA(Gly) as donor.  Involved in resistance to methicillin (By similarity).
What are the official names of this protein?
Aminoacyltransferase FemB, Factor essential for expression of methicillin resistance B, N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase.
What is the protein family that this protein belongs to?
Belongs to the FemABX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEP5_FUSLA
Sequence: MPHFRESSSSSENGAIDHDLQHTFQRILSDDQYTKFSPNEPPLSQQLEPIAVVGMGCRLPGDVSSPSDFWKLMMEKKSGQTPKVPSSRFNIDAHFHPDNDRPGSFGVLGGYFINETLKEFDPAFFGITPVEATWMDPQQRKLLEVVYEAFESAGLTLDQLSGSDTACFMATFTADFQQMSFKEPSFRHSLAATGVDPGLLSNRVSHVFNLRGPSIVVNTACSSSVYALHNACNALRTHECSAAVVGGSNLILTVDQHMNTAKLGVMSPTSTCHTFNSYANGYGRAEGVGAIYLKRLSDAVRDGDPIRGVIRSSATNNNGKAPGVGITYPGFDGQRTVMRHAYQRSGLDPMLTGYFECHGTGTAIGDPLEVHAVSDIMNAARKDADGPLNIGAVKTNIGHSEAASGLSAVIKSILMVERGIIPPTHGVTDLNPKIDWKGWKVHVPTDPIPMPKHLPVTRVSVNSFGYGGTNAHTIIESPKSLLSAPQNYKYSMSGPTIKAKQPRGATRRNRPHLLVFSAHDTGTLKRNAAALGKVAPNYNLLDLSFTLANHRTRFQSRGMVVTTPATLQKTFTDGMPDFMVASKNVTARNLGFVFTGQGAQWAGMGQQLMTYYPTFLKAIRRMDLVLEDLDDAPSWTLEESLLENPETSRVGEAEFSQPLCTAVQVALVQLLRTWGIRPSVTLGHSSGEIAAAYAAGYLSEADAILAAYYRGQVVKSIDTSGAMMAVGLGAEAVKSYLEPFQAEVVVACHNSPVGVTLSGNIDALKAIEETLKVDGVFARLVKTNSKAYHSHHMLPAVDKYETLLRDNSQKGISGVSLNKVKMVSTVTNSVLSEDAVLDGKYWSANLVSPVLFNQAIQSALTNKDMHIDTLIEIGPHSALSGPIRQIKAELGADKVQYLPTLIRGSPCAGQVLKLAGEFFLRDYPINLSQVSMLEETSPSGKILSRSGNLIVDLPPYQWDKTKKFWAESRESKEHRSPRFPRHDVLGQLTIGGSLTEPTWRNVLRLKDLPWLRDHSLGGEAVFPAAGYLAMAMEATTQLNEMSGSPREIKSYVFRDVRIQQALVTPDDDDGIEVLFNMCPSRLATDNTATQSWDFNASSVSPEGHLKNHMAGSIRINTSNKQRAVARPVPNLPQRASGKLWNQALKKVGFNYGPTFQDMDNITFDGTSYCAQSMTNLKSTVMDNESRYVLHPAILDSCLQLMIVAIWAGRAGAMKFGAVPVNAEEIVIWRPTATQLDNSSAAKAFSWIDPRGQRLFNAHNQLLAGDGEVLMEIKSMRCTAYEAAIPQTLETNVQPEPYSQMVSKPDVSFLNGDQRDLDLADFIALAHFKNPALRVLATDASTASLLLSRIPALGLTVATGSSGVSDMEAQFAGFDNASVLSLDLNDSLARQSHEKLTRSFNLVISPGASMATLRTVSELLLEGGQAVLQQDPTFSDQGLKDAGFSGLECFLGQSMFVTSSIQTRKPVLSTVQLLYHTNPTSHMSPLELQLRDAGIKTERLKLGDSCTPGANIIALADLERPLIASMSEFDFLQIQKTLSEASKILWVSCGGSLEGSPEYAMTRGLLRSLRSERAALKATLVDFVPDDLDTNEFSLRTTSLAATLFEGDQELETEYLARDGQLLITRLVPFDIVNQRHGHNGDETQPHPFDAETNLVGKVEAGKVVFEHSRSDPEPLQETEVEFRPLATGLTAEGRAIISGASFETDFSHEASGIVTRVGDAVNKVSIGDRVVAFSSNTFSNFQRVQECLVQRLQDDEDSATMASLPLYYGAALYGLETLARLRPGESVLILPGLGLLGAAAIKVAQALGGHPSVAVRDSAEAEEVEVAFGVPRSQILVAYSPDRLMRCHEIDVVFSGSTTEPLLAEESWRNLPALSRFVSCSNSSASAAPSFASTAISRGASYLSVNITGLFKKPHILGGLLERIIELFRSGLIPAPLLNVQNIAEINHIGSPSSQSLSSTETVLVHEKGTGTVDVVQSRPRLELRSDATYLLVGCLGGLGRSLTTWMMKRGACHFAFLSRSGTDSEQARICVQELEARGANVQVFRGDAAVKEDVEMAVASISAHCPLRGVVNAAMVLRDGLFQNMSYDNWTTSIRPKVLGSKNLHEAIASLDLDFFLMTSSVSGILGTPTQANYAAANSYMDALACLRRRQGKHACAVVLPMILGVGVVAQDLDLEVSLKRKGMYGIDEEALLSAFEAAIFEQQHSQDSQSNFDHLVVGLEATKLYNARQEAEGDVDAFWTTDPRFSVLLDDMKQHSGDNQGDGEKGSILSQVKAASDSPAQAISLVRDHFISKLARVLLLDQDEFDDDGSGRSIASYGIDSMIGAELRNWIFKELGLDVAFQQLLSPSLTISKFAELVCAAQGIVLDNE
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099, PubMed:28460114).  The reducing polyketide synthase DEP5 is the central enzyme in depudecin biosynthesis by yielding the backbone polyketide chain (PubMed:19737099).  The monooxygenases DEP2 and DEP4, as well as the uncharacterized protein DEP1, then act as tailoring enzymes to modify the intermediate polyketide chain into depudecin (PubMed:19737099).
What are the official names of this protein?
Reducing polyketide synthase DEP5, Depudecin biosynthesis cluster protein 1.
Protein: RL23_STRR6
Sequence: MNLYDVIKKPVITESSMAQLEAGKYVFEVDTRAHKLLIKQAVEAAFEGVKVANVNTINVKPKAKRVGRYTGFTNKTKKAIITLTADSKAIELFAAEAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: CCME_BRASB
Sequence: MTRKQRRLTIIGGALFVLAVAAGLVLNALRDSIVFFSTPTMVAEKHIGPGKRFRLGGLVQPGSLKRGDDLAVTFEVADGGAKLPVAYKGILPDLFREGQGVVAEGALDAAGVFKADTVLAKHDETYMPKEVADTLKKQGHWKDDYGKPQAAKPGPVSMREGEKTAAGATQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: HISZ_LIMF3
Sequence: MQDYKLPAGLRDNFGPQATQKESVRHYLTGLFQRHHYTLIETSLLEYRDVFGPYELQAESLYRILEADGQDLVLRPDLTLPIARFLVTTNVSLPTSFAYVGEQFRRNRQLTGLYNQSTQAGIELVGFQSRRAELECLTVISELNRDLFNGRLLVELGQARLADLVLADLPANERQKEAIKAALFNKNVPDYEAAIAPFKRERHYPFLAEWTWLFGKADVVEKMVAPLWVNPAAREAMQEVLDLAKLVAQLGDQELLVDFSTAAPQAYYTGVTFKAYADQTSTYLVSGGRYDNLLANFQEKSEPAIGLGIDVTLIAQLLERSAPRDQAKPTLVFCQLADWPTFAKRYGGDPAYEACLADSLVAARTQAAATGQQLKVMNEEGDLIDA
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_TETTH
Sequence: MSQLVWEIVKNNNAFLVKNNGVAFTTDPFSVTGRNTQVGLGFTHRHGVALKGGAKQAIATSLRKNQSHKVKKTGTIEAETLTVKGGVQRVAKVIRGRFQSKGLKQFALKKLVNFHRANVRAQANLKAESKAKKN
What are the official names of this protein?
60S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL28 family.
Protein: YEGW_ECO57
Sequence: MEQAHTQLIAQLNERILAADNTPLYIKFAETVKNAVRSGVLEHGNILPGERDLSQLTGVSRITVRKAMQALEEEGVVTRSRGYGTQINNIFEYSLKEARGFSQQVVLRGKKPDTLWVNKRVVKCPEEVAQQLAVEAGSDVFLLKRIRYVDEEAVSIEESWVPAHLIHDVDAIGISLYDYFRSQHIYPQRTRSRVSARMPDAEFQSHIQLDSKIPVLVIKQVALDQQQRPIEYSISHCRSDLYVFVCEE
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YegW.
Protein: SYFA_DECAR
Sequence: MENLDQIVSEAQVAFAAISDPDALEQVKARFLGKSGQITELLKGLGKLPPEEKKTAGAAINVAKTAVETALNERREAIRKAALDARLAEEALDVTLPGRAEARGGLHPVTRTLERIESLFASIGFEVADGPEIEEDFYNFTAMNTPEDHPARSMHDTFYLQNSDGTLADKVLLRTHTSPIQARYMQAHVKRYGQLGKMPEIRIIAPGRVYRVDSDATHSPMFHQVEGLWVGEGVSFADLKGVIANFLKSFFETDDLTVRFRPSFFPFTEPSAEIDVAFMSGALKGRWLEIAGCGMVHPNVLRIAGIDPEKYTGFAFGFGQDRLTMLRYGINDLRLFFEGDLRFLRQFN
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NKAI1_MOUSE
Sequence: MGKCSGRCTLVAFCCLQLVAALQRQIFDFLGYQWAPILANFLHIMAVILGIFGTVQYRSRYLILYAAWLVLWVGWNAFIICFYLEVGQLSQDRDFIMTFNTSLHRSWWMENGPGCLVTPVLNSRLALEDHHVISVTGCLLDYPYIEALSSALQIFLALFGFVFACYVSKVFLEEEDSFDFIGGFDSYGYQAPQKTSHLQLQPLYTSG
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1, Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1, Protein FAM77C.
What is the protein family that this protein belongs to?
Belongs to the NKAIN family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YMF26_MARPO
Sequence: MDENRQVRFFQPFKKMFQTSQTSSVTGWIGSCVGGTSVSLLRLDGPKRPCVYPSIFIAVWKTK
What are the official names of this protein?
Uncharacterized mitochondrial protein ymf26, ORF63.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RRF_BORPE
Sequence: MSVADIRKSAETRMAKSLETLKASLAKIRTGRAHTGILDHVQVEYYGSPVPISQVANVNLVDARTISVQPYEKSMAGPIEKAIRESDLGLNPVSMGETIRVPMPALTEERRRDLTKVVKSEGEDAKVAVRNLRREANEALKKLVKDKEISEDDERRAQDDVQKLTDRAVGDIDKMIVQKEAEIMTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPS6_RICCO
Sequence: MAEKDKYRPLANFPSTAWGCSFASFSSSNSDFELYTREVETLKEKVRPMVTASTKDPLENVQIINLLYRLGVSYHFENEITDQLNHIFEIIPNHIISDDNDYDLYTVAILFQILRQYGHKVPCDVFNKFKNSDGKFKKSIANDLKGLLSLYEASFLSVHGENILDEAIAFTRPLLESFADQSSPHLAKYIRNSLLRPHHQGIQRVEARQYISFYEEDESRNETLLKFAKLDFNRLQLLHKQELASLSRYKKYIAQIIIWEDLNLAKELPYIRDRLVETYLWAIGAHFEPQYALSRAIIAKYTTIVSAVDDTYDAYGTLDELQRFTNAFQRCDIDAIDELPDYMKVLYRALLNFFDQIEDEVDEGRSYSTSVAKEAFKELVRSYYVEAQWFSDGYVPSFDEYMRNGLITSTYTVLPAASFIGMENTVGEKEYKWVQSNPKIVKAAKIICRLMDDITTHEDEQKRGHCASSIECYMKEYGVSEKKAIEEIQKICANAWKDMNEECMKKPPTVSRTLLKYYVNLARVIDFVYKNLDSYTYASSLKGDITTVFLELLPV
What is the function of this protein?
Probable sesquiterpene synthase.
What are the official names of this protein?
Probable terpene synthase 6, RcSeTPS6.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: SIX2_LEIQU
Sequence: MKLLLLLIVSASMLIESLVNADGYIRKRDGCKLSCLFGNEGCNKECKSYGGSYGYCWTWGLACWCEGLPDDKTWKSETNTCG
What is the function of this protein?
Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis.  They bind voltage-independently at site-4 of sodium channels and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  Aside from typical beta-toxin effects, this toxin also affects the inactivation process and ion selectivity of the insect voltage-gated sodium channel.  This toxin is active only on insects (PubMed:15733572).  Is active on the insect voltage-gated sodium channel para (PubMed:15733572).  In vivo, when injected intraperitoneally, it exhibits analgesic activity, increasing hot plate and tail flick withdrawal latencies in a dose-dependent fashion (PubMed:20619318).  This phenomenon might be partly due to an inhibitory mechanism activated by noxious stimuli (PubMed:20619318).
What are the official names of this protein?
Beta-insect depressant toxin LqqIT2, Insect toxin 2.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FTSB_SODGM
Sequence: MGKLTLLLLVLLGWLQYSLWLGKNGVHDLVRVESDVAAQQSNNAQLKARNDQLFAEIDDLNGGQGAIEERSRNELGMIKPGETFYRLVPEQSKRQPAAPATQDNQ
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: TAL1_BACCR
Sequence: MKFFIDTANINEIKEANELGVLAGVTTNPSLVAKEGVDFHERIREICNVVEGPVSAEVISLEADKMIEEGKELAKIAPNVVVKVPMTTEGLKAVKAFSDLGIRTNVTLVFSAVQALLAARAGATYVSPFLGRLDDIGHNGMDLIRQIAEIFAIHGIETEIIAASVRHSVHVTDAALNGAHIATIPANVIASLVKHPLTDQGIEKFLADWEKTQEK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase 1.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_PSEPK
Sequence: MSGKPPAIFLMGPTAAGKTDLAIELTTVLPCELISVDSALVYRGMDIGSAKPSKEVLAAHPHRLIDILDPAQSYSAAQFRADALEAMAEITARGKIPLLVGGTMLYYKALIDGLADMPAADATVRAELEAQAEALGLAELHRQLAEVDPESAARIHPNDPQRLIRALEVYRVSGESMTAHRRRQFAESRGADAGAGGHLPYTVASLAIAPTDRHILHQRIALRFSQMLEQGFVDEVRSLRARSDLHAGLPSIRAVGYRQVWDYLDGKLTENEMRERGIIATRQLAKRQFTWLRGWPEVHWLDSLACDNLSRTLKYLGAISILS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: MEPA_STAAB
Sequence: MKDEQLYYFEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFDVGAGTYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVSLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIIYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNKGRMKDVIKAVIMSIGVIFVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPVLFIMNALFGLTGVMWSLLIAESLCALAAMLIVYLLRDRLTVDTSELIEG
What is the function of this protein?
Multidrug resistance efflux protein.
What are the official names of this protein?
Multidrug export protein MepA.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LUXS_SHESM
Sequence: MPLLDSFTVDHTRMNAPAVRVAKHMSTPKGDAITVFDLRFCAPNKDILSERGIHTLEHLFAGFMRDHLNGSDVEIIDISPMGCRTGFYMSLIGEPSERQVADAWLASMEDVLKVVEQSEIPELNEYQCGTYQMHSLEQAQDIARNIIAAGVSVNRNDDLKLSDEILGKL
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: DNLI_ANADE
Sequence: MLLAELAEVSRAVAATPARLEKIARLADALGRLAPDERAVGASWLAGDLPGGRVGIGAATLRAALEAAPPERSGPGLTVAEVDAALRRIAAVAGPGSGAARRRELDALLARAGNPERRFLAALVLGELRQGALEGVLADAVAKAAGLPAAEVRRAAMLAGALPPVAEAALSEGAAGLARFRLRVGEPVSPMLAQTAADVDEALRALGGEAALEWKLDGARIQAHRDGEAVRVFSRSLRDVTAAVPEVVALLRAAPEPRLVLDGEAIALRADGTPEPFQVTMRRFGRKLDVERLAPELPLTAFFFDALVAGGAELLARPERERWAALARAIPAERRVPRLVTRDPAEARAFLEDALARGQEGVVAKALDAPYEAGRRGAAWLKVKRAHTLDLVVLAAEWGSGRRRGWLSNLHLGARDPASGGFVMLGKTFKGMTDAMLAWQTDRLKALATGPLDAWQVPVRPELVVEVAFDGIQSSPRYPGGLALRFARVKRYREDKRPEDADTIETVRGLYGG
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
Probable DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: CPI10_SOLTU
Sequence: TCHDDDNLVLPEVYDQDGNPLRIGERYIIKNPLLGAGAVYLDNIGNLQCPNAVLQHMSIPQFLGKGTPVVFIRKSESDYGDVVRLMTAVYIKFFVKTTKLCVDETVWKVNNEQLVVTGGNVGNENDIFKIKKTDLVIRGMKNVYKLLHCPSHLECKNIGSNFKNGYPRLVTVNDEKDFIPFVFIKA
What is the function of this protein?
Probable inhibitor of cysteine proteases.  May protect the plant by inhibiting proteases of invading organisms.
What are the official names of this protein?
Cysteine protease inhibitor 10, PCPI-10, Pcpi10.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.
What are the subcellular locations of this protein?
Vacuole.
Protein: RL35_STAAW
Sequence: MPKMKTHRGAAKRVKRTASGQLKRSRAFTSHLFANKSTKQKRQLRKARLVSKSDMKRVKQLLAYKK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: CLPX_CHLTE
Sequence: MIKDKEPRKGQNGGRKSYGSEPPVVCSFCGRTSQEVNSMVAGPRAFICDRCILSSVEILRKEISAIRHPDQSPEPAFQPRLKSPVNIKEALDQYVIGQEQAKKSLAVAVYNHYKRLDAHDWSSGDEVVIEKSNILLIGPTGTGKTLLAQTLANLLEVPFTIADATSLTEAGYVGDDVETILARLLHASDFNLERAERGIIYVDEIDKIARKSANVSITRDVSGEGVQQALLKILEGSVVGVPPKGGRKHPEQQLININTKNILFICGGAFEGLDKIIARRVSKSSMGFGSKVRGKQTGYDPEILKLVTQDDLHDYGLIPEFIGRLPVMSVLEPLDAVALRNILVEPKNALVKQYKRLFEMDGVELEFTDEALERVVAIAIERGTGARALRSVLENVMIDIMFELPTRKDVQKCVITAETIDKTGGPVYEKKDGKERKIA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.