PharMolix/UniProtQA huggingface dataset:
Protein: K1210_MOUSE
Sequence: MEGFEASGEEGKKKSKFKAFKNFFSKKKKKEPEEIPEVAVLKPRFSSSSVSGSSLQPALEKQVMESKPKSGMGVKSISHDSVFCLDPEPEKGAGKLHSSPAPHRSKSLKIKSQRSQRLSISPLIRSEKVCEELEKFFASDRTTTTFRRRSSQCSSTPRMSSELSLDPETSESSTQQFSGFSTPATSQGCLDSSAAKSKIALNPRKQKKRKSTSTPVKVKQEEQLQSVPAKEKTTTKTKEAEQGEQKVDSTELSSQEQSSKTETQDTAVDKTPSTDPALRLNPRRRRRRAKNEWEILERGLLKSTQRYSLNTKAESSANKEIAGKEHSFLKLLLEKKDIGQPTTTEAEVTTVQKMPSDKGDVERELADIDVEAQKEPAPQPTSTDVAESMISGPSPHCEDKKKKDKVGVLPWIKKSTSQKEVTVLRKEEVQVHVHPSRVCGEGEEASCPELQRVQPQMKVSLESTTYHKEKHPRSGLPVPSTSISSATAEDDVSPKMNLPLPLRRRPNTGETSSDSKSTSEYESSSEMQLSPAHSFKPTRKPKDDAGAGTADDEEDGDDEKEEKDNDDDDEENVFLKSENVDVEVSKMEKQQALRYSSKLLGKPKAREASAKLESSSEDERSCEEMTSAHSSQSLEEFEECSESRGFIRGSISEERPATRCHSQALQELEEKEVSTESSSYIEKYESSEDLSSSEQEQQVPPVSKSSLKQWSAPAKPVHPIQTAQQQPPAMVNISGGPKKSGEPLSPTQTVKSRLRSQSECQVLAEPEGVVAADWDILMQPPPRPRLEQEVSAGPELTVFEKSIAVQPSGYPPQPSVKPSIKKEISLGAESAPLESPPPQHHFQPLLKPFVKQQVSAFERVISMDPKLPTQFQPRMKPQGKQSFSSTPESTAFEGSTSVDHMTLTLSQPMLQPYQEVPLESETVAAKMISTGQLHSKYSAHPLSSHQSQPVPESTSAEGEELLPSQPSVTPKFQPLMTQGSIPSAWAIPIYSPAPRMDSKPLMGSAIALESKPSRYSLQPWQSTPFEQVSVTPDHDPAAAAASWSPPIDPPTSRIPSQPLMRLAVKQPTCTELASVSVSQSSSLERLSSRFPFQPRADPEHYGAEEGVATLRRSRRHHSQSPVRSEFKEEVSSGSRRAFGERSISVGKMPPKYALQPWLCPEFQQQAKEGDVLRKAWLSGHPSQTISKHKVEKTPLPPKCPSPFLTRSKVQEISSRLESVIAQESSKKPQRGRPPSKSFVNFMAQQVFSESAPSKVVLHPKPVARGRRRPSRSLLKPKLDDYAFLYNWDNEPKEDTTLQNLPMKQPFQLSRKPEEPQEVLPFSEGAPVKWNTSARGISQALGKLSVSVSLPNEWKSSEGQLPSTQPSQAFDVAKLQSPVLPVDSANVPVKWRISEGHQPPQSFFVDYQPQVSVDSASAAAKGASCWPMLKDSASTTNVKYSQGYKDFTKSTPTSVIKPATFTSAPAQKPMVSMGTYFKDEVPKCCDETGTSSLLPTSKADVENVFGVRLRSTSQKIGMKNPDPCKPFVLISAAARKEQANKGDLQGSVGGSKQSRPAFSFEKKQGNWPRYEGTLKKSEVFRPPVAFYDQKMLHPRTRERLTRRSLSLPPTLPQREEPEWFSVAKKKAQAWSQIANIMQ
What are the official names of this protein?
Acrosomal protein KIAA1210.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localizes to the sex body in spermatocyte, acrosome, and near the ectoplasmic specialization.
Protein: ACKA_SULDN
Sequence: MKIAVINSGSSSIKFKLYLMPQSIVLAHVHVEKIGETSSKITFRHTDKKEVFSNKIDTHHEGLRVINDILKEYQIIEHFSSLDAIAHRVVHGGDFFKSATLINEDVIYKIRELIPLSPLHNRANLEGILVSLKKAPSVPQIAVFDTSFHASLPKEAYLYALPYELYKEHKIRRFGFHGISHAYVLKKVAQEMQKNLHGLNMITLHLGNGSSACAIRNGKSVDTSMGFTPLEGLVMGSRSGDIDPQIVIYLQKELGYGLDEVEELLNRHSGLIGVCGEIDLREIIKRDDELSHVALDMMTRRVKKYIGAYMALLGRVDAIAFCAGIGENSSEVREKILKNLELFGIELDTKANEKNLTKISKQTSKIEVFVINTDEELEIALEAEALLRA
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S7A6O_HUMAN
Sequence: MEAARTAVLRVKRKRSAEPAEALVLACKRLRSDAVESAAQKTSEGLERAAENNVFHLVATVCSQEEPVQPLLREVLRPSRDSQQRVRRNLRASAREVRQEGRYRVLSSRRSLGTTSSGQESEYTPGNPEAAGNSGFQLLDLVHEEGEPEAASAGSCKTSDPDVILCNSVELIRERLTVSEDGPGVRRQEEQKHDDYVYDIYYLETATPGWIENILSVQPYSQEWELVNDDQEPEDIYDDEDDENSENNWRNEYPEEESSDGDEDSRGSADYNSLSEEERGSSRQRMWSKYPLDVQKEFGYDSPHDLDSD
What is the function of this protein?
Directs RNA polymerase II nuclear import.
What are the official names of this protein?
Probable RNA polymerase II nuclear localization protein SLC7A6OS, ADAMS proteinase-related protein, Solute carrier family 7 member 6 opposite strand transcript.
What is the protein family that this protein belongs to?
Belongs to the IWR1/SLC7A6OS family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PUR5_ECOHS
Sequence: MTDKTSLSYKDAGVDIDAGNALVGRIKGVVKKTRRPEVMGGLGGFGALCALPQKYREPVLVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASAVISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVLIALGSSGPHSNGYSLVRKILEVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKVDVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNCGVGMIIALPAPEVDKALALLNANGENAWKIGIIKASDSEQRVVIE
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRA1_STRSL
Sequence: MNMSTNYSTTNQSYKHLSEAERGEIEAYLSVGLKPAEIARRLGRNRSTITREINRGSITQVKKVNGAKGLLPTLLCRCCSITVIRHAREASYYLKLDSVSDDFMRAFTDAMREKPRVHSVDTFVHTYRLQHVDAVVPSTKTLYNYIHQGLLEIKVIDLPRRVRIRKKFTKRPSTKKHLGKSIEERPEEINNRSRFGDWEIDSVLGGKTIGEPSILTLVERQTRYAVTKKLVEKKAEYVNQAVLECMKLYPIKSITADNGNEFSSLSKIEGLDVYFAHAYSSYERGTNENFNGLLREFIPKGCSLKELNQNLLEDYTKAINERPRRIHGYQSAKKLFELTQTA
What is the function of this protein?
Required for the transposition of the insertion element.
What are the official names of this protein?
Probable transposase for insertion-like sequence element IS1161.
What is the protein family that this protein belongs to?
Belongs to the transposase IS30 family.
Protein: PYRB_CERS5
Sequence: MTFRARHLLGIEQLAPDEIRSVLDLADSYVDLNRRTMKQSDALAGMTQINMFFENSTRTQSSFELAGKRLGADVMNMAVAQSSVKKGETLLDTAMTLNAMHPDLLVVRHPASGAVNLLASKVNCAVLNAGDGRHEHPTQALLDALTIRRAKGRIQRLTVAICGDIAHSRVARSNLILLGKMENRVRLIAPPTLMPPGVGEFGCELYDDMKKGLEGADVVMMLRLQKERMDGAFIPSEREYYHRFGLDADKLAFAREDAIVMHPGPMNRGVEIDGTLADDINRSVIQDQVEMGVAVRMACMDLLARNLRAERGRAAVGVMV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TRYP_APIMS
Sequence: IVGGTAADISQFPHQLSLQTT
What are the official names of this protein?
Trypsin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: GLMS_BARQU
Sequence: MCGIIGILGKKCVASSLIAGLKRLEYRGYDSSGIATVHNGRLYRVRAEGKLVHLEEKLKKTPLKGSLGIGHTRWATHGVAVERNAHPHVTERLAIVHNGIIENFVELQKELIEEGYTFETETDTEVIAHLITRALKSGLSQQEAIRTSWKRLQGAFAIVVIFEGQDNLMIAARSGPPLAIGYGQDEFFVGSDAVALASFVDRISYMEDGDWAVLTREGVTIYGADNQPVKRPITTLFEGTLLVSKGNHRHFMHKEMFEQPEVISHNLAHYLDLGNYTVRSLKNLIDWKKINRILFASCGTAYYSTLVARYWFENFAALSVDNDIASEFRYREPPITSDVLSVFVSQSGETADTLACLRYCREHGVKTATIVNVEQSTMAREADFILPTRAGPEIGVASTKAFTCQLATLAAMALDAAKQRGSLSEKAEHQFVQQLAEVPRILNEVLKLDDKIEQICRDLVNVRGVLYLGRGTSYPIALEGALKLKELSYIHAEGYAAGELKHGPIALVDEAIPVIVVAPYDRWFEKTFSNMQEVAARNGRIILITDKRGAEVAGLDTLSTIVLPNIPEFIAPIIYALPIQLIAYHTAVLLGTDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCM1_HUMAN
Sequence: MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
What is the function of this protein?
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928, PubMed:20354224, PubMed:26956484).  CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).  Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores.  May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion.
What are the official names of this protein?
Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A.
What is the protein family that this protein belongs to?
Belongs to the Orai family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Isoform beta is more mobile in the plasma membrane (PubMed:23307288). Colocalizes with STIM1 at the cell membrane (PubMed:27185316).
Protein: IRAP_KLEP3
Sequence: MKNLIAELLVKLAQKEEEAKELTVQVEALEIVVTALLRHMEHDAQQALIQDIEQAIDQVTPCPPVNDQDAMLLQQYLKKLLRHPRS
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraP.
What is the protein family that this protein belongs to?
Belongs to the IraP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBJ_NANDO
Sequence: MADTTGRIPLWLIGTVAGILIIGLLGVFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SPED_BUCAP
Sequence: MQKLKLYGFNNLTKSLSFCIYDICYANTNDSRNSYISYIDEQYNAIRLTKILKKTCSIIGANVLNVFHQDYEPQGASVTILVCEEPINLEKVNIVNKSNKIISSSVLAHLDKSHICVHTYPESHPQSGICTFRADIEVSTCGIISPLNALNYLIHQLESDIVTIEYRVRGFTRDIHGIKHFIDHKINSIQNFMSHDIKSMYEMFDVNIYQENIFHTRMLLKEFNLKNYLFNINVKDLSKKEHSYIIDLLWKEMREIYHGKNISMIKKI
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: RL28_SHEHH
Sequence: MSRVCQVTGKRPMVGNNRSHAKNATRRRFLPNLQNHRFWLENEKRFVQLRISTKGMRIIDKKGIEVVIAELRARGEKV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: LPAS_STRMU
Sequence: MQEQILASCVNLLATLNQKCLFPCNNKGFFIEFNSLWTFFFV
What are the official names of this protein?
Aspartate-semialdehyde dehydrogenase leader peptide.
Protein: NUOH_NITEC
Sequence: MDSFQPLFEQLFGSEWGVSLFLLAKNLLLILAIIIPLLLAVAYLTFAERKIIAFMQVRVGPNRVTFFGIPWLGGWGQPIADAVKAIMKEIIIPTGANKFLFLLAPILAITPALAAWAVVPFSPELVLADINAALLYILAMTSLGVYGVIIAGWASNSKYAFLGAMRSAAQVISYELAMGFALVCVLMMSSSLNLGDIVAGQQGGSFLNWYMIPLFPMFLVYFISGVAETNRLPFDVAEGESEIVAGFHVDYSGMAFTIFFLAEYANMILVATLASIMFLGGWLPPVDIIPFNLIPGVVWLLLKIAIMLFFFLWFRATFPRYRYDQIMRLGWKVFIPITLIWIVLLGAVMQLPEAALQSFPLNLWF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCA_ACIET
Sequence: MQIYMVGGAVRDRLLGRPVNDHDWVVVGATPDDMVARGYLPVGRDFPVFLHPETREEYALARTERKSGRGYRGFVVQTSPDVTLEEDLSRRDLTINAIAASADWTGAEDLFDPYGGARDLQARVLRHVTDSFREDPVRILRVARFAARFTDFTVAPETMQLMREMVHDGEADHLVPERVWQELARGLMEPQPSRMFDVLRDCGALAVVLPEVERLWGVPQRPEYHPEVDTGVHLMMVLDMAAHLQAPLTVRFACLTHDLGKGTTPHDVLPRHIGHEQRSARLLKAVCERLRVPVECRELADVVAREHGNIHRSGDLGAAALVRLLERCDAIRKPARLDEILLACECDARGRLGFADRPYPQRARINAALAAVQSVTTSSVAAHAAQLGLSGPKVGEMIHAARVQAVADWLHATAQPAPEPRGNAG
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: KHSE_BURVG
Sequence: MAVFTAVSDSDLAQWMRHYELGDVLAFRGIPSGIENSNFFLTTTRGEYVLTIFEKLTAEQLPFYLDLMRHLASHRVPVPDPVPRDDGALFGLLHGKPAAIVTKLDGAAELAPGVEHCIEVGQMLARMHLAGRDYARQQPNLRSLPWWQENVPAIVPFISDAQRALLESELAHQAAFFASDDYAALPSGPCHCDLFRDNVLFAHAAPGTGHDVRLGGFFDFYFAGCDKWLFDVAVTVNDWCVDLATGVLDTARADALLRAYQTVRPFTAEERRHWSDMLRAGAYRFWVSRLYDFYLPRAAEMLKPHDPGHFERILRERIAHTPALPETHTACN
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: CUT1_SCHPO
Sequence: MSTRSIVTSKVSWTPEKFISALSYPEHCSITLVKRLKASVKLKDLKQNISRDAPSWTFEHLFVAFKCAVSNLAKQWAELSTTDKEKTRRMFCTPSRLNTAHRPEVFYLLECCTYILEQMQVVTKNTSHLYDCIRSGVSICNRLLDMEIFEPAISLLMKTHKNLIILLTYRDHDAIPTATLLNPTLDVSEIQLESCLFVPMVPASYFLNIGTIVVTFQLNVLRCLSLSQINGLSLNTINNLQSEDGPFQWIERSFPSQVQLANSRREILARLLTRFSMIQNNALQSFKLLILSIALWLNILSSQRADDKEFDVNQLETRILQLFSKVVQLCKSEDIEGSILNKDMTQLHHLLENLSKESRLHILLQLSQLYYKYNDFQLSAAYVIRGYSLSFEDISFKLKFLLFSFRLSIHDNSICFPFNLIQELSSLQQLFVENALPYSEALHLLDSIERSFRLFNDSTVFDDTVFALNISEILSWILSSVVRDILVEDELLNLQLKIRKFLMFTFHIIRSFSELTKFQSSLEGCLNLAAYYEDAEFPQKLSNHLYNLCVKSSNVNYARECISLSIKIAVSHKLTNDETYLLKILKNFQLRYHDSLQLQEKCDVLHTTFNQLDLYVGTTSVGKSSVLDNILKRIFNSLTSINDSNIEKLLESISYSLLKLFFKCANEGSRYNASAALSFKLSLMLHEKEEVLLLKTNVSCVLANHGYNDIKFEEMVLCVIKGDQNLLEHNSNNNAKLALNESLLCSWENLLCYRRAEDDSRILTIIESWTIFISRFSSVISRCSFTDFEINSILNFFFCFLHTVEPSGKLTFELAFLEIFYELFNCLLHLQFSKYLVIIGTLLSDKYMTLGFSGKAHLFYTKCYSYLRQCKSSPFINFWNVSYGKYLILTGNTDKGILQLKKYSLSSEEDFNSNGLSRTVSLNLLLYERIQLSDALFQLGYTTVSLGFIMQNLKVIKGLFSKSSKEHFNGGKYITWRLFAVSAHSNVCAARIYEHMGQAREAEFFYRQACSISEKMPFSCFSATFQLRLCSLLTRAGKLEKGEKILFDLTEAMKSTDTYHKLLWNYGAAEVCATKSELDGAICHYSECVKLLEIIKSEYYLFFNRNREKSLTKGIKRLSLSSQPTFVTESNTTEFDDWSILQNTAANLLRLISMFELKRGNLEIAKALMTDSTKCSIASFFNIVSANILKSKLIVCEADSTLFGDPVLRTLPDSVISLPGISHKFQKNQSKTKALGENTGFRKGSKRLDYLRERLKINLQNVRLSCEIIFSNAYERSSVCVCREVNELISYSTIMQSALTTIGETTDVDSSSASFFLEIPKALGFHRRREAQKFRNQHKELHFSSLEQILNSRLSIPDVRTFQDNFIDSLPSIWNVVSITINNSGEDLFISKIRKGHSPLIFRLPLQRHNSRDADEEILVFTKAQTELFRIISKSNQMAQNGKHYTRREDKETWWKERRHLDQCLQQLLENIEISWLGGFKGIFNPHKIDTSLFAKFSSQFQNIIAKNFNMDKKTPVPTLSPEILELFITLGKPGYEGYEQLLEDLIYFILDIFQFRGLHFAYDEIDTDQLSMDLQDALNAYFNNYVSEENRSHTVLVLDKSVHQFPWESLPCLNRQSVSRVPSLSILRDILSQSFVVNGEYVEVRKEAGSYILNPSLDLKHTQEMFEHKLVEGGWKGLIASQPSNRDFIKMLSGNDFFLYFGHGGGEQYTTSYDLATLKRCAVTILMGCSSGALYECGSFEPWGTPLDYLSAGCPTLVANLWDVTDKDIDRFSLKMLESWGLFENKAPFVNSTSICTAVSESRSCCHLRYLNGAAPVIYGIPAYIIP
What is the function of this protein?
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the rad21 subunit of the cohesin complex at the onset of anaphase.  During most of the cell cycle, it is inactivated by securin/cut2 protein.  It is also required for pointed nuclear formation.
What are the official names of this protein?
Separin, Cell untimely torn protein 1, Separase.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: IL10_MERUN
Sequence: MPSSALLYCLILLAGVRPSRGEYPRNESNCTHFPVSQTHMLRELRAAFSQVKTFFQKKDQLDNILLTDSLQQDFKGYLGCQALSEMIQFYLVEVMPQAENHGPEIKENLNSLGEKLKTLRMQLRRCHRFLPCENKSKAVEQVKNDFNKLQEKGVYKAMNEFDIFINCIEAYMTIKMKS
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1076_ARCFU
Sequence: MEVIQISKDELEEIIERKFKEVLIKALMEITPYVSDEEQEEIDKIAGKPDEYEGEFEEWHGK
What are the official names of this protein?
Uncharacterized protein AF_1076.
Protein: ALN_ORYSJ
Sequence: MAMAAAKGRVLPLLAVAAALAAALLYRAPFSKSLGGEGCSLLPHDHFWIASERVVTLGRVGPAAVEVKGGLINAIAVGDYRSFLLRRPVVDYGDAVIMPGLIDVHAHLDEPGRAEWEGFSTGTRAAAAGGITTLVDMPLNSYPSTVSEETLKLKLDAAKDKLHVDVGFWGGLVPENALNPSALESLLNAGVLGLKSFMCPSGINDFPMTNSTHIEEGLVTLAKYKRPLLIHAERIPDVQNEDGIDGELDPKAYTTYLKSRPPAWEEAAIKDLQRAMKDTEIGGRSEGAHIHIVHLSDAKTSLGLLKDAKQNGARVSVETCPHYLAFSAEEVPDGDTRFKCAPPIRDSTNRDNLWEALLDGHIDMLSSDHSPSAPDLKLMEEGNFLRAWGGISSLQFVLPVTWSHGKKYGISLNQLASWWSERPAMLAGLKKKGAVLPGYRADIVVWKPEAQFHLDDSHPVYHKHRNISAYLGKQLSGKILSTFVGGNLVFAEDKHAKAACGAPILAK
What is the function of this protein?
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoate by hydrolytic cleavage of the five-member hydantoin ring.  Catalyzes the first step of the ureide allantoin degradation followed by the sequential activity of AAH, UGLYAH and UAH which allows a complete purine breakdown without the intermediate generation of urea (By similarity).
What are the official names of this protein?
Probable allantoinase, OsALN.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
Protein: YCNB_BACSU
Sequence: MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDFNVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNFPVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGWAVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYGFSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGTLVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGLAIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLIPHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIALVGFLLSFTLKKPQRPAEQQPAR
What are the official names of this protein?
Uncharacterized MFS-type transporter YcnB.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EmrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLYA2_RHIME
Sequence: MPGLFERQLKHDSVIAGAIAREMGRQRSEIELIASENIVSPAVLAAQGSVMTNKYAEGYPGHRYYGGCQYVDLVEAAAIERAGMLFDASFVNVQPHSGAQANGAVMLALLKPGDTFMGLSLAAGGHLTHGARPTMSGKWFNAVQYGVRESDCLIDYDELEVKAIATRPKLIITGGSAYPRLIDFKRIRAIADSVGAAMMVDMAHFAGLVAGGVHPNPVEIADIVTTTTHKTLRGPRGGMILTNNQDVAKKVNSAVFPGLQGGPLMHVIAAKAVALGEALEDNFRQYARQMVANARALASALTERGYDIVSGGTDTHLILVDLRSKGVSGKDAEEALGRAGLTCNKNGIPFDPAPPAVTSGIRLGTPAATSRGFREAEFNEVGALIANVLDALGTEQSGEQERRARMSVHDLCAAFPIYSARH
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 2, SHMT 2, Serine methylase 2.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOA_GEOTN
Sequence: MSNIYANSYLIVFVFLCLGVLLPIGALTIGRWLRPNVPDEAKATTYESGNIPFHDSRIQFQVRYYLFALLFVIFDVETVFLYPWAVVYDQLGLFALVEMIIFIVLLAIGLIYAWKKKVLRWM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARCH_SULIL
Sequence: MRSFEFFEHTADVGIRAYGKSLEEAFSNAALGVFEVITDTSKVKPIEYREIYLNGYDLENLLYKWIEELLYYYDSELMVFSKFDLMIDQDSMTLEGKAWGEKFNGKIHERRTVVKAMTYHQLSIEKTENCYVITFVVDI
What is the function of this protein?
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB.  Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation.  Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
What are the official names of this protein?
Protein archease.
What is the protein family that this protein belongs to?
Belongs to the archease family.
Protein: ICAR_STAAC
Sequence: MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYSIDALYQFLFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLLNIFLKK
What is the function of this protein?
Represses transcription of the icaADBC operon necessary for biofilm production.
What are the official names of this protein?
Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR, Intercellular adhesion protein R.