PharMolix/UniProtQA huggingface dataset:
Protein: CALM_STRIE
Sequence: MSQELTINADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTSK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: RS17_ACHLI
Sequence: MEQVKNKKLYTGKVVSDKMDKTITVQVETHRVHRIYGKAVKVSKKFHAHDENNVAKMGDTVTIAEHRPLSKTKKFILVSVDKTAEIV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RIMM_RHOJR
Sequence: MELVVGRVAKSHGIKGEIVVEVRTDEPEDRFAVGAVLRGHKPREQTVSTYTVEAARDHSGRLLLRLEGVSDRTAADALRGTLFVIDSAELEPSDDPDEFYDHELEGLSVRLADGTEVGTVIEVLHSAAGELLSIRRAGDQSGELLVPFVAAIVTSVSVADGVALIDPPEGLLDPDFGESADGK
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNA_FERNB
Sequence: MKLKTMTMEWTGDSLILIDQRRLPFEEVYVTCADYRAVALSIKEMVVRGAPAIGATAAFGYVLGAKEILKKSHNYEQVVMQMKNVKETLAKTRPTAVNLFWALERMEKRLIRHGKYEGLVKVLEDEALKIAKEDIEVNKAIGRNGAQLLQDGFTVLTHCNAGALATVDYGTALGVLRAAKEQGKKIKVYADETRPYLQGARLTAWELMKDGFDVTLISDNMAGWVMKQGKINAVIVGADRIAANGDVANKIGTYMVAVLANRHGIPFYVAAPLSTIDMSIKSGKEIPIEERSHEEVLTCGGKRVAPNNVNVYNPAFDVTDHELVTAIITEKGVVYPPYEENIKKLFEEGI
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: COAD_ANOFW
Sequence: MASIAVCPGSFDPVTYGHLDIIRRGAKVFDKVYVVVLNNSSKKPLFSAEERVQLLEEVTKDLHNVVVDSYQGLLVDYAKSKHASAILRGLRAVSDFEYEMQITSMNRILNEQIETFFMMTNNQYSFLSSSIVKEVAKYNGNISELVPKVVEEALRKKFAHAENHL
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3193_MYCTO
Sequence: MGMRSAARMPKLTRRSRILIMIALGVIVLLLAGPRLIDAYVDWLWFGELGYRSVFTTMLATRIVVCLVAGVVVGGIVFGGLALAYRTRPVFVPDADNDPVARYRAVVLARLRLVGIGIPAAIGLLAGIVAQSYWARIQLFLHGGDFGVRDPQFGRDLGFYAFELPFYRLMLSYMLVSVFLAFVANLVAHYIFGGIRLSGRTGALSRSARVQLVSLVGVLVLLKAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAAAVFSAIALRDLRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSITATRQAYGLTSDVVTYRNYSGDSPATAQQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFPDQLSIDRYLDRNGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGFIASPANTVRGIANDPNQNGGYPEFLVNVVGANGTVVSDGPAPLDQPRIYFGPVISNTSADYAIVGRNGDDREYDYETNIDTKRYTYTGSGGVPLGGWLARSVFAAKFAERNFLFSNVIGSNSKILFNRDPAQRVEAVAPWLTTDSAVYPAIVNKRLVWIVDGYTTLDNYPYSELTSLSSATADSNEVAFNRLVPDKKVSYIRNSVKATVDAYDGTVTLYQQDEKDPVLKAWMQVFPGTVKPKSDIAPELAEHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASSYQPPYYIVAKNIAKDDNSASYQLISAMNRFKRDYLAAYISASSDPATYGNLTVLTIPGQVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGNLLTLPVARGGLLYVEPVYASPGASDAASSYPRLIRVAMMYNDKVGYGPTVRDALTGLFGPGAGATATGIAPTEAAVPPSPAANPPPPASGPQPPPVTAAPPVPVGAVTLSPAKVAALQEIQAAIGAARDAQKKGDFAAYGSALQRLDEAITKFNDAG
What are the official names of this protein?
UPF0182 protein MT3285.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GUF1_FUSV7
Sequence: MSLAWSAGRAWSRQSYAAPPAAAKTPPSELEARIAAIPIERYRNFCIVAHIDHGKSTLSDRLLEYTGTISASDANKQILDKLDVERERGITVKAQTCTMIHNHEGEDYLLHLVDTPGHVDFRAEVTRSYASCGGALLLVDATQGIQAQTVSNFHLAFAQDLALVPVVNKIDMPAADIPRVLEQMQNSFELDPKDAIMLSAKTGKGVPNVLPAVIERIPHPVGDEKKPLKMLLVDSWYDNFRGVVLLVRLFDGTIKTGDNVISLGTGMKYTVGQVGIQYPHATPTKVLRAGQVGYVYFNPGMKKIQDAKLGDTFTFVGAEDNVEPCPGFEEPKPMVFVAAFPTDQSDYSRLADSINQLVLNDRSVTLQKDFSEALGSGWRLGFLGSLHCSVFQDRLRQEHGKSVILTEPTVPSKIIWPDGSEEVVQNPALFPDVSHPRIRGAQLFEPFVTATITMPEEYLGRVIELCEANRGEQKSLEFFHTTQVILQYEIPAAQLVDDLFGKLKSATKGYATLDYEDSGWRQSHLVKLQLLVNRQPVDAICRVVHSSQVDRLGRQWVTKFKEHVDRQHFEVVIQATAGNRIVARETIKPFRKDVLAKLHAADVSRRRKLLEKQKEGRKRLRASFMSR
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: GUAAA_METM7
Sequence: MIVILNNGGQYVHRIQRSLKYLGVPAKIVPNSTTLEEITVNPEIKGIILSGGPDITKATNCENIALNSEIPVLGICLGHQLISKAYGGHVSRADSEEYASIKIYVKEENDLFKGVPSEFTAWASHMDEVKVTPECFEILAYSDICGVESIKHKEKSLYGVQFHPEVSHTEYGDVLLKNFCKKCGFEFEE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit A, Glutamine amidotransferase.
Protein: SELU_SHEON
Sequence: MTTTLIPAQQYRDIFVAGKPLIDLRAPIEFNRGAFPSSVNLPLMVDKEREKVGTCYKQQGQQAAIALGHSLVHGAVKQQRIDAWLGFLAAQPEAYLYCFRGGLRSQLTQQWLKEAGATVPYVQGGYKGMRQYLIGVIETTPSQQPLLSLSGMTGSGKTDFLIQRKEAVDLEGIANHRGSSFGKNIDPQPTQINFENQLAIALLRHQQDNHSCLLLEDESFLIGRSALPQSFYNAMQAADILVLEEADDIRLNRLLDEYVHKMHQGFVERLGIEAGFNAFSQYLLQSLTSIRKRLGGKQYQELQDTMQQALSQQLNQNQTSQHLAWINLLLQKYYDPMYEYQLEKKAHRVLFRGNHQAMHEWLDNLSQDSLSQENLG
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: GE_EHV4
Sequence: GSTWPSRCHSTLLGDRPHFIQPAPNRVDLLFKDIPESATGLYVFVLLYNGHPEAWTYTLLSTANHFMNVLTDRTRPRLGEHFYTDHGHQLFTPHPSEATTQELGAWTRHYLAFLLIIICTCAALLIALVVWGCILYIRSNRKPYEVLNPFETVYTSVPSNDPTDEVLVFERLASDSDDSFDSSSDEELELPQPPPAAQLQPYSSLESADASRGRSGFKVWFRDTPEASPEPLHRPTPPVGPDYSKVASKLRSILK
What is the function of this protein?
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions.  Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions.  Implicated in basolateral spread in polarized cells.  In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system.  Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips (By similarity).
What are the official names of this protein?
Envelope glycoprotein E, gE.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein E family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass membrane protein. Host endosome membrane; Single-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein. The heterodimer gE/gI then redistributes to cell junctions to promote cell-cell spread later in the infection (By similarity).
Protein: BIOD_LEPBL
Sequence: MAVFIGATGTDIGKTLFSSLILGKYGKSLGLKYFKPVQTGNDSDRVTLMNLTGLHESYFLKNYYSLSFAGSPHYASELEGVEIDSDELSRHLYSIRDEKIIVEGAGGLLVPLTRKILTLELVRQSEIPLILVAPVSLGAINQTLLAIEAVQNRKIDLKGIYFIGIPDKTTEDNIRTITEWSGVTLLGNFFLNSKEKMSRERFQIECLSRFDQCEVIKKMFV
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPD_ECOL6
Sequence: MQQLQNIIETAFERRAEITPANADTVTREAVNQVIALLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIEGAESRYFDKVPMKFANYDEALFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIGQSTRIYDRETGEIHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_CAMFF
Sequence: MELIFLSIALAMDSVAISMANGARCMNIKALQIFKMSFLFGIFQAFMPVIGYFLGLAFVGFISYIDHYVAFAILLFLGIKMIKESRQISVHCSLNLSLRMLMLGAFATSLDALAVGITFSFEEINIAIAAFVIGLVCFVLCVIASYMGRVLGEMLESKALVLGGVILILIGCKIIITHLIN
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PH2_PERAM
Sequence: LDLTPGSHVDSYVEA
What are the official names of this protein?
Peptide hormone 2, Pea-VEAacid 2.
Protein: RL20_MYCLE
Sequence: MARVKRAVNAHKKRRTVLKASKGYRGQRSRLYRKAKEQQLHSLGYAYRDRRARKGEFRKLWISRINAAARANDITYNRLIQGLKAADVDVDRKNLADIAISDPAAFTALVEVARSGLPEDVNVPSGEAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: SYFB_VIBCH
Sequence: MKFSESWLREWVNPAITTDELTHQITMAGLEVDDVLAVAGVFDGVKVGHVVECAQHPDADKLRVTKVDVGEEELLDIVCGAANCRQGLKVAVATVGATLPGDFKIKKAKLRGQPSHGMLCSFSELGIDVESNGIMELAENAPIGMDFRDFLSLNDVTIDVDLTSNRADCFSIRGLAREVGVLNRADVTAPAVNAIVATINDTISIDVKAPAACPRYLGRIVKNVNVQAQTPLWMQEKLRRCGIRSIDPVVDITNFVMLEQGQPMHAFDLAKIEGGIVVRLAEQDEKLTLLDGSEAKLNADTLVIADQQKALAIAGVFGGEHSGVSTDTKDVLLECAFFAPDHIRGRARSYGLHTDSSMRFERGVDYALQHAAMERATQLLVEICGGDVAPVVAAESAADLPKPNQVALRRSKLDKLLGHAIPDADVVEILERLGMQVETTAEGWQATAPTWRFDIAIEQDLVEEVGRIYGYNNIPNQAPVAALNMNLHNEAKLPLKRVRDLLVDRGYQEAITYSFVEPEQQKLVVPGVDALILPNPISAEMSAMRLSLIQGLLNTVVHNQKRQQPRVRLFEYGLRFIPDAAAENGMRQEPMLAGVISGARGEEHWNMETATVDFFDMKGDLEAVLELTAKGKAYSFAATKHPALHPGQAAAIMVDGKAIGVIGTVHPELERKFGLNGRTIVFEIEWNAINTRVIPEAAAISKFPANRRDIALVVDGNIASGDIVEACRVAGGELLKDAKLFDVYVGKGVEEGKKSLAIALTLQSVERTLEEADIAAAVEAIVQAVSAQFGAALRD
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_XYLFM
Sequence: MDRIIDTAATREDEAIEVSIRPKRLADYLGQQPVREQMDIYIQATKARAEALDHVLIFGPPGLGKTTLSHVIAYELGVKLRVTSGPVIEKAGDLAALLTNLQPYDVLFIDEIHRLSPVVEEVLYPAMEDFQIDIMIGEGPAARSIKIDLPPFTLIGATTRTGLLTAPLRDRFGIVQRLEFYSPEDLARIVRRSAGILNIDCTTEGAAEIAQRARGTPRIANRLLRRVRDYAEVKAGGQITIEVAQAAMQMLKVDQGGFDELDRRLLHTIVEYFDGGPVGIESLAASLSEERGTLEDVVEPYLIQQGFLVRTARGRMATDKAYQHLALQPRERVSAFTDPEDLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: HIS1_DESOH
Sequence: MTQVLKFGIPKGSLQDATIALFKRCGWKINVNGRSYFPDINDPDISCALLRAQEMARNVEHGTLDAGLTGKDWIAENNSDVHVVADLVYSKASARPARWVIAVAKDSPIQKLEDLEGKTVSTELVNYTKRFFQEKKISVNVEFSWGATEAKVVSGLADAIVEITETESTIRAHSLRIIHEMMQTHTQLIANHDAWKDPFKKAKLEQIALLLKGALLGEKLVGLKMNVPHAGLDAIVNLLPSLNAPTVAPLYQSDWFAVETVVDSETVRDLIPELMAKGAQGIIEYPLNKVI
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_LACJO
Sequence: MSLPVVALVGRPNVGKSTIFNRIINSRVAIVEDKAGVTRDRIYARAEWMGHEFILIDTGGITLDSGEIEEQIKAQAEIAIDEADVIVMLGDVTQHMTNMDETIAKMLYRTKKPVILAINKADNPEQRTDIYDFYSLGLGDPIPVSGSHGTGMGDLLDAIVGEFGDKANQHEDGSIRFSVIGRPNVGKSSLVNAILGEQRVIVSNIEGTTRDAIDTTFTNDGQKYTIVDTAGIRRRGKVYEKTEKYSVLRAISAIEESDITLLVLDASTGIREQDKHVAGYAHDAGRGVIIVVNKWDLPKKDSRSMKDFEDTIRREFQYLDYAPIIFVSAKTGQRVPDILKLVKEVHENQTRRIQSSVLNDLLLEATRITPTPLVNGKRLRIYYMTQVAVTPPTFVVFVNDPELLHFSYQRFLINQLRQNFDFVGTPIKILARKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: AP2E_MOUSE
Sequence: MLVHTYSAMERPDGLGAAAGGTRLSSLPQAAYGPAPPLCHTPAASATADYHPPYFPPPYPQAPLPYGQGPDATAAFPHLAADPYGGLAPLAQPQPPQAAWAAPRAAARAHDEPPGLLAPPARALGLDPRRDYAAAVPRLLHSLADGAHGLADAPLGLPGLAEPPGLEELQAIDDPGMSLLDQSVIKKVPIPSKAGSLSTLALSKDSLVGGISNPSEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHADPGELHSRKSMLLAAKQICKEFADLMAQDRSPLGNSRPALILEPGVQSCLTHFSLITHGFGGPAICAALTAFQNYLLESLKGLEKMFLSGAGGGHGESKASEKDTKHRK
What is the function of this protein?
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes.  AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development.  They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.  AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation.
What are the official names of this protein?
Transcription factor AP-2-epsilon, AP2-epsilon, Activating enhancer-binding protein 2-epsilon.
What is the protein family that this protein belongs to?
Belongs to the AP-2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: K1C25_MOUSE
Sequence: MSLRLSSGSRRSYARPSTGSLRGASFGAGNACGVAGIGSGFSCAFGGSSTGGNTGVANSCAGFTVNEGGLLSGNEKVTMQNLNDRLASYLDNVQALQEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDDLKNQIITSTTSNANAVLQIDNARLTADDFRLKYENELALHQSVEADVNGLRRVLDEITLCRTDLEIQYETLSEELTYLKKNHKEEMQALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSASLQQQITEDVGATTSARNELTEMKRTLQTLEIELQSLLATKHSLECSLTETEGNYCTQLAQIQAQISALEEQLHQVRTETEGQKLEYEQLLNVKAHLEKEIETYCLLIGGDEGACKSSSYKSKDYGSGNAGNQIKDPVKAIVVKKVLEEVDQRSKILTTRLHSLEEKSQSN
What is the function of this protein?
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (PubMed:14996088, PubMed:17920809).  Plays a role in the cytoskeleton organization (By similarity).
What are the official names of this protein?
Keratin, type I cytoskeletal 25, Cytokeratin-25, CK-25, Keratin-25, K25, Type I inner root sheath-specific keratin-K25irs1, mIRSa1.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF12_METAC
Sequence: MAEYCTYEKYVFKKQLETLKSKNGRSTELISLYIPPDKQISDVTKHLREEHEQASNIISKLIRNNVQEALHSLLAKLRSLHKIPENGIVYFTGTVDTGANRTGMVNEVLFPPEPVADYIYRCDSVFYLEPLEEMLRECTTYGLLLLDLREATIGMLVGRQTEVIKHLHSTVPGKQRKGGQSAHRFEQLRRIAIHDFYKRIGDATSEAFLELDPAELKGILIGGHSPTKEEFNEGGFLHYELQKKVLGLFDTGYTDESGFSELINAAEETLQSIDLLKQKKDMEIFFKEIATESGKISYGEDNVRANLEIKAVDVLLLSEELRAERVTLKCRVCGYENKRTRKWKTGEAVPAIGHCPECDSELEVTDVIDTVGELSELADKGDARIAFISTDFDEGSQLMIAFGGIAAILRYNTGV
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
What are the official names of this protein?
Peptide chain release factor subunit 1-2, Translation termination factor aRF1 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBB_BABBO
Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDQSGTYHGDSDLQLERIDVFYNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQITHSLGGGTGSGMGTLLISKIREEYPDRIMETFSVFPSPKVSDTVVEPYNATLSVHQLVENADEVQVIDNEALYDICFRTLKLTTPTYGDLNHLVSAAMSGVTCSLRFPGQLNSDLRKLAVNLIPFPRLHFFMIGFAPLTSRGSQQHRALSVAELTQQMFDAKNMMCASDPRRGRYLTACAMFRGRMSTKEVDEQMSMVQNKNSSYFVEWIPHNTKSSVCDIPPKGLKMAVTFVGNSTAIQDMFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATIDDDADDMVNDY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: CF300_BOVIN
Sequence: MAAGEPGDLGVYSFRFLPQKTFQSLSTPQTTSRLRQWSMLGRIEAQAFGFDQTFQAYRKDDFVTAFFKDPNVIPNLKLLSESSGEWLTLGTEVKKIEAINVPCTQLSMSFFNRLYDEAIVRDNGYIVKCLDSFCDPFLISDELRKVLLVEDSEKYEVFSQPEREEFLFCLFKHLCLGGALCQYEDVINPYLETTKLIYKDLVSVRKNPQTKKIQITSSIFKVTAYDSVGVCYPSTKSHEQTFSYFIVDPIKRHVHVLYHCYGMGEVS
What is the function of this protein?
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility.  May play a role in outer and inner dynein arm assembly.
What are the official names of this protein?
Cilia- and flagella-associated protein 300.
What is the protein family that this protein belongs to?
Belongs to the CFAP300 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme.
Protein: PPARD_XENLA
Sequence: MKEEIPPRSPILDEQPSTPLEHQETSQSVDCKICGDRASGFHYGVHACEGCKGFFRRTIRMRLQYEHCDRNCKIQKKNRNKCQYCRFNKCLSLGMSHNAIRFGRMPESEKRKLVQAPVSDSAAPDSPVSDLDVLSQLIHSSYMNTFTMTKKRARDILTGRNSISPFVIHDMDTLWQAEQGTVWEQLPTQNLTGTEIGVHVFYRCQCTSVETVRALTDFAKRIPGFGTLYLNDQVTLLKYGVHEAIFCMLASLMNKDGLLVAGGRGFVTREFLRSLRQPFCHIMEPKFHFASKFNALELNDSDLALFVASIILCGDRPGLINPSQVEDIQEGILGALRRHLKASHTDAPFLFPKLLHKMADLRQLVTEHAELVQSIKRTESSAALHPLLQEIYRDMY
What is the function of this protein?
Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues.  Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids.  Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid.  Once activated by a ligand, the receptor binds to promoter elements of target genes.  Regulates the peroxisomal beta-oxidation pathway of fatty acids.  Functions as transcription activator for the acyl-CoA oxidase gene.  Decreases expression of NPC1L1 once activated by a ligand.
What are the official names of this protein?
Peroxisome proliferator-activated receptor delta, PPAR-delta, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSPA_MYCS2
Sequence: MPQGTVKWFNAEKGFGFIAPEDGSADVFVHYTEIQGSGFRTLEENQKVEFEVGQSPKGPQATGVRTI
What are the official names of this protein?
Probable cold shock protein A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM52_XENLA
Sequence: MPLLYCCPGFYLSSSVTRLLCVRLRNSVDLSRTGNRSVHSSTLRCAGQDWRVRRGFARSGSEYGPLTDLPDWSFADGRPAPPWKGQIRRKEEREALARRVVLLSTEMDQGMTNWHKKQQEMKAEQLQKEISKLKSKASPNKTTNT
What are the official names of this protein?
39S ribosomal protein L52, mitochondrial, L52mt, MRP-L52.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL52 family.
What are the subcellular locations of this protein?
Mitochondrion.