PharMolix/UniProtQA huggingface dataset:
Protein: RUBY_DESVH
Sequence: MKSLKGSRTEKNILTAFAGESQARNRYNYFGGQAKKDGFVQISDIFAETADQEREHAKRLFKFLEGGDLEIVAAFPAGIIADTHANLIASAAGEHHEYTEMYPSFARIAREEGYEEIARVFASIAVAEEFHEKRFLDFARNIKEGRVFLREQATKWRCRNCGYVHEGTGAPELCPACAHPKAHFELLGINW
What is the function of this protein?
May provide oxidative stress protection via catalytic reduction of intracellular hydrogen peroxide.
What are the official names of this protein?
Rubrerythrin, Rr.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHLB_ECOLI
Sequence: MSKTHLTEQKFSDFALHPKVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTSTFHYLLSHPAIADRKVNQPRALIMAPTRELAVQIHADAEPLAEATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMYDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELAFEQMNNAEYIEVEPEQKTGHRIKEELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILDEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGHSIPVSKYNPDALMTDLPKPLRLTRPRTGNGPRRTGAPRNRRRSG
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Forms a cytoskeletal-like coiled structure that extends along the length of the cell. Formation of this structure does not require the presence of RNase E, MinD and/or MreB.
Protein: FOLD_ECOK1
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDALNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQGE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: NUOH_XANCB
Sequence: MNELLLNVVDPLHQWFLGLGDGGVLLWTVLKILLIAVPVIVTVAFYVVWERKLIGWMHVRHGPMYVGMGIFQAFADVFKLLFKEILQPSSSHKAMFIIAPLLTLAPAFAAWSVVPFDAKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGVMIASGSVNLSQIVFAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIVAGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVTADVSPWVNWLWTGGWPWLLMKVFFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQKGV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: 2A5D_ARATH
Sequence: MFKQILGKLPKKTSAKFWDNGESQTLDNNNNQGGGDEVLSQRTSSNGDTSLDCVSSFDVLPRLRDVSISEKQELFLKKLRLCCLVFDFVAEPQQNFKEKEIKRQTLLEVVDYVISSGNGKFPESVIQEATKMISANLFSNPHRQWKNKTPEALDLEEEEGSLNPSWPHLQIVYEFLLRIVASPNTDPKISKKYIDHTFVLKLLDLFDSEDPREREYLKTILHRIYGRFMVHRPFIRKTMNNILYDFIFETGKHSGIAEFLEVLGSIINGFALPLKEEHKLFLTRVLIPLHKLKCLPNYHQQLSYCVIQFVEKDCKLADTVIRGMLKYWPVTNSAKEIMFLNELEEILEATQLTEFERCMVPLSRQIAQCLSSSHFQVAERALYLWNNDHVTNLVRQNSRIILPIVFPALEKNGSSHWNQAVKNLTENVLKVLSDTNPDLFEECLHKFQEDQQKAEDTKKKNGETWRQLEEIVASMAK
What is the function of this protein?
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
What are the official names of this protein?
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform, AtB' delta, PP2A, B' subunit, delta isoform.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B56 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_BLOPB
Sequence: MRYYEIVFMVHPDLSEQISSIINRYTTIVTNAQGKVHRIENWGRRQLAYPVNKLCKAYYVLLNIEVSQDTVKELNDDFHFNKNIIRSMIVRTKYAIVEPSPMMKKIEENQEHHATNI
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: LSRG_YERPN
Sequence: MHVTLVEINVKEDKVDQFIEVFRANHLGSIREAGNLRFDVLRDEHIPTRFYIYEAYTDEAAVAIHKTTPHYLQCVEQLAPLMTGPRKKTVFIGLMP
What is the function of this protein?
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.  Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD).
What are the official names of this protein?
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase, Autoinducer 2-degrading protein LsrG, AI-2-degrading protein LsrG, Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase, Phospho-AI-2 isomerase.
What is the protein family that this protein belongs to?
Belongs to the LsrG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_RHOP5
Sequence: MRTDLFDFDLPQGAIALRPASPRDAARMLVVEASGALHDRVVSELPEWLRPGDALVVNDTKVIAAQLTGRRIGRDTEPKIDATLIKRLDGSRWQALVKPAKKLLPGDIVRFGHDGRVCLLGQLDATVEAKGEAGEIILAFTLHGPVLDQAIAELGAPPLPPYIASKRAPDDRDAADYQTMFAANEGAVAAPTAGLHFTKALEQALAARGVTLHRVTLHVGAGTFLPVKTEDTAEHKMHAEWGCLSRETADALNAARAADGRIVAVGTTSLRLLESAAGDDGRLAPFADDTAIFITPGYRFKAVDVLMTNFHLPRSTLFMLVSAFAGLDTMQRAYAHAIKSGYRFYSYGDACLLFRNPS
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_STRPJ
Sequence: MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAADAADAGAAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPALVKEGVATAEAEEIKAKLEEAGASVTLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: ACSL6_RAT
Sequence: MQTQEILRILRLPELSDLGQFFRSLSATTLVSMGALAAILAYWLTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGDCTQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPEQPYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQFIGVFAQNRPEWIIAELACYTYSMVVVPLYDTLGPGSIRYIINTADICTVIVDKPHKAILLLEHVERKETPGLKLVILMEPFDDALRERGKKCGVDIKSMQAIEDSGQENHRVPVPPRPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHFSYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALRPTIFPVVPRLLNRMYDKIFHQADTSLKRWLLEFAAKRKQAEVRSGIIRNNSIWDELFFNKIQASLGGHVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDAEELNYWTSKGEGEICVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSEPVAQIYVHGDSLKAFLVGIVVPDPEVMPCWAQKKGIEGNYQELCKSKELKKAILDDMVMLGKESGLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM
What is the function of this protein?
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804).  Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase 6, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 6, LACS 6, Long-chain-fatty-acid--CoA ligase, brain isozyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: HELI_HHV6U
Sequence: MSISSLFGGRYDNKFLLNMSSAPKIELIVDKVASLSERRLEGRLPEDWFRHIMDPETEFNSEFADALCIGIDEFAQPLPFLPFKALLVTGTAGAGKTNSIQTLAANLDCIVTATTSIAAQNLSVVLNRSKSAQVKTIFKTFGFNSSHVSMSERQSYIANDERSIQIQQKQDLSIYWNVISDIADRALGAVACKTKELPDLCESSVIVIDEAGVILRHILHTVVFFYWFYNALYKTPLYEDGIVPCIVCVGSPTQSNALVTSFNPLTQNKDVKRGIDVLSALICDDVLSKYCEVDNNWIIFVNNKRCADHAFGDFLKHIEFGLPLKPELIEYVDQFVKPASYIRNPMNEIETTRLFLSHNEVKNYFRSLHEQVEVTNRNNLFVFPVYFLIKNKTFEDYKSEIGNFSLEIEPWFKSNIHRLNTYSQFADQDLSKTVQLEEIVLEDGSVEETLITCHLKHIRNSSIGVTSKIKASTVGFSGTYEKFVELLQSDLFIEKTSCDQTIHAYSFLSGLMFGGMYSFCCSKFTTPEVLMEIKNIKMPSIEFLESEMSRMSPDVQTVETDERYDFGLVNDGLSDVDLLEIDPCGDPFFTRYSKLPLTNSLSFEEISLLYTTFKDIFISRFAILQKHTKGKFGKTLLVTYNRNNVSRKQCGEIYSHLKSFYGMLTYAIPANNYTLEGYTNDNVVHLGTDKQLPQILYKKGLPRLVIKDEMGFISVLDNNVSKFIDVVNGQSFHLCTTVDYATVSKVSMTITKSQGLSIQKVAIDFGSDPKNLKLSSIYVGMSRVTDPNNLIMNVNPLRLNYENDNFIAPHIVKALKNENTMLIF
What is the function of this protein?
Component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs.  Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
What are the official names of this protein?
DNA replication helicase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae helicase family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: YPT2_CAEEL
Sequence: MPRDDPITEEERRANSATDLIRMRLARLQQNIDKPAPIPIKKETLRAPKEPLEFVRNVVGSSAAAGSAEFHIYRNNRRKEQNRLDYIDAVAKKEELDDAYRHKVEKLEKEEESKTAKKRAKRLRQKAAAKKRKLTKKNNESDESSSDDSDSDSGSGSDNESEGKQNTEVEDKDKVEKEETDDEKTEVST
What are the official names of this protein?
Uncharacterized protein F37A4.2.
Protein: SYFA_BARHE
Sequence: MSDIERLEQEICLALEMAGDEQALEAVRIAALGKKGSISEKLKALGKMSASERQKVGPVLNGLKNRVLELWTQKRDFLRRQAMDACLTRETVDITLPVRSSPIERGRIHPISQVIEEIIAIYMKMGFSLAEGPDIETDYYNFTALNFPEGHPAREMHDTFFFDVNKTGERKLLRTHTSPVQIRTMEKQKAPIRIIIPGKTYRMDSDATHSPMFHQVEGLVIDKTSTIAHMMWLHETFCKAFFEVSSVKMRFRPSFFPFTEPSMEVDIQCDRSGSEVKFGEGQDWLEILGCGMVHPHVLKNVGLDPDEYQGFAWGMGIDRIAMLKYGMPDLRAFFDADLRWLDHYGFRCFDMHAFFPGLRNV
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSLA4_ORYSJ
Sequence: MEGQWGRWRLAAAAAASSSGDQIAAAWAVVRARAVAPVLQFAVWACMAMSVMLVLEVAYMSLVSLVAVKLLRRVPERRYKWEPITTGSGGVGGGDGEDEEAATGGREAAAFPMVLVQIPMYNEKEVYKLSIGAACALTWPPDRIIIQVLDDSTDPAIKDLVELECKDWARKEINIKYEIRDNRKGYKAGALKKGMEHIYTQQCDFVAIFDADFQPESDFLLKTIPFLVHNPKIGLVQTRWEFVNYDVCLMTRIQKMSLDYHFKVEQESGSSMHSFFGFNGTAGVWRVSAINEAGGWKDRTTVEDMDLAVRASLKGWQFLYVGDIRVKSELPSTFKAYRHQQHRWTCGAANLFRKMATEIAKNKGVSVWKKLHLLYSFFFVRRVVAPILTFLFYCVVIPLSVMVPEVSIPVWGMVYIPTAITIMNAIRNPGSIHLMPFWILFENVMAMHRMRAALTGLLETMNVNQWVVTEKVGDHVKDKLEVPLLEPLKPTDCVERIYIPELMVAFYLLVCASYDLVLGAKHYYLYIYLQAFAFIALGFGFAGTSTPCS
What is the function of this protein?
Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose.  The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase.  Galactomannan is a noncellulosic polysaccharides of plant cell wall.
What are the official names of this protein?
Probable glucomannan 4-beta-mannosyltransferase 4, Cellulose synthase-like protein A4, OsCslA4, Glucomannan synthase, Mannan synthase 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: RPOB_CHLAB
Sequence: MFKCPERVSVKKKEDILDLPNLIEIQIKSYKQFLQIGKLAEERDNIGLEEVFREIFPIKSYNEATILEYLSYNLGVPKYSPDECIRRGITYSVTLKVRFRLTDETGIKEEEVYMGTIPIMTDKGTFIINGAERVVVSQVHRSPGINFEQEKHSKGNILFSFRIIPYRGSWLEAIFDINDLIYIHIDRKKRRRKILAITFIRALGYSSDADIIEEFFQIEEHSLKSEKDFSFLVGKILADNVLDEASSLVYGKAGEKLSTAMLKRMLDANISTLKIAVEADENHPIIKMLAKDPTDSYEAALKDFYRRLRPGEPATLANARSTIMRLFFDPKRYNLGRVGRYKLNRKLGFPMDEESLAQVTLRKEDVIGALKYLIRLKMGDEKASIDDIDHLANRRVRSVGELIQNQCRSGLARMEKIIRERMNLFDFSSDTLIPGKIISAKGLASVLKDFFGRSQLSQFMDQTNPVAELTHKRRLSALGPGGLNRERAGFEVRDVHASHYGRICPIETPEGPNIGLITSLSSFAKINEFGFIETPYRIVRDGVVTDEIEYMTADVEEECVIAQASANLDEYNMFVDPVCWARYRGEAFEADTSTVTHMDVSPKQLVSIVTGLIPFLEHDDANRALMGSNMQRQAVPLLKTEAPIVGTGLEARAAKDSGAIVVAEEDGVVEYVDGYKVVIAAKHHPTLKRTYDLKKFLRSNSGTCINQRPLCSVGDVVVKGDVIADGPATDKGELALGKNILVAFMPWYGYNFEDAIIISEKLIKQDAYTSIYIEEFELTARDTKLGKEEITRDIPNVSEEVLANLGEDGIIRIGAEVKPGDILVGKITPKSETELAPEERLLRAIFGEKAADVKDASLTVPPGTEGVVMDVKVFSRKDRLSKSDDELVEEAVHLKDLQKGYKNQISVLKIEYREKLGALLLNEKAPASIIHRRTADILVQEGTVFDQETIELLEQESLVDLLMPPCDMYDVLKSLLSDYETSLQRLEVNYKTEVEHIREGDADLDHGVIRQVKVYVASKRKLQVGDKMAGRHGNKGVVSKIVPEADMPYLANGETVQMILNPLGVPSRMNLGQVLETHLGYAAKTAGIHVKTPVFEGFPESRIWDMMIEQGLPADGKSYLYDGKTGERFDNTVVIGYIYMLKLSHLIADKIHARSIGPYSLVTQQPLGGKAQMGGQRFGEMEVWALEAYGVAHMLQEILTVKSDDVTGRTRIYESIVKGENLLKSGTPESFNVLIKEMQGLGLDVRPMVVDA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PPDB_ECOLI
Sequence: MPVKEQGFSLLEVLIAMAISSVLLLGAARFLPALQRESLTSTRKLALEDEIWLRVFTVAKHLQRAGYCHGICTGEGLEIVGQGDCVIVQWDANSNGIWDREPVKESDQIGFRLKEHVLETLRGATSCEGKGWDKVTNPDAIIIDTFQVVRQDVSGFSPVLTVNMRAASKSEPQTVVNASYSVTGFNL
What is the function of this protein?
Not yet known.
What are the official names of this protein?
Prepilin peptidase-dependent protein B.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FBL56_ARATH
Sequence: MVDLVSSLPDDLLGHILSLLTTKEAALTSILSKRWRYLIAFVPYLEFDDSAFLNPEEGKQTREGTRQSFIDFVDRVLALHGDSPIRKFSLKCKTGVDLDLLNQWICNVLQRGVLLIDLSMDLGHRCMFIEIFMSRTLVELKLGSGCRIAFGPEHISALPMLKTLTLDSVSWSDSGQLERLLSACPALEALNLANVHGSYPNATVSIASLKTLTIKSVSLSGPAHVFSFDTPNLLCLNYTALFEDDYPLVNLEYLVEAQIKFVLTDRLIKLVSVRKNGLLMLSEVQKLIRGISSVRKLYLSPGTLQVLGQCSQAMPVFNNLTFLVIESSMDIRWQAMPVLLKNCPRLETLVIKGGLVHCVAADCGDACTCISREEKGRSLASCPVKRLEIREFQGTLREMEMIKHFYYCFLCLKEMEIYVKDGRPQFLAPLASDSNPFKHLLGRNVIIKVHGSLT
What are the official names of this protein?
Putative F-box/LRR-repeat protein At3g58880.
Protein: MA6D1_MOUSE
Sequence: MAWPCISRLCCLARRWNQLDRSDVAVPLTLHGYSDPGSEESGADCSVSRGNPSVAGARESSRAVPLTQYQRDFGVRTARAGSRDAAQERPSGPGGRRGQSSAPPTRTVYVLPVGDADAAVVATTSYRQEFQAWTGVKPSRSTKARTARVVTTHSSGWDPSPGASFQVPEVRKFTPNPSAIFQTSAPQTLNV
What is the function of this protein?
May have microtubule-stabilizing activity.
What are the official names of this protein?
MAP6 domain-containing protein 1, 21 kDa STOP-like protein, SL21.
What is the protein family that this protein belongs to?
Belongs to the STOP family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasm, cytoskeleton. Note=According to PubMed:16837464, it colocalizes with microtubules.
Protein: APAG_PSEAB
Sequence: MSDTQHQVNVRVDTRYLPEQSAPEQNRFAFAYTVTIENQGEVPAQLLSRHWIITDGDGRTQEVRGAGVVGEQPLIAPGAQHTYTSGTVLATRVGSMRGSYQMLGSDGIAFDAAIPVFRLAVPGALH
What are the official names of this protein?
Protein ApaG.
Protein: SYH_STAAN
Sequence: MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVVQKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGRYRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNEALVKHFEPVIHEFCSDCQSRLHTNPMRILDCKVDRDKEAIKTAPRITDFLNEESKAYYEQVKAYLDDLGIPYIEDPNLVRGLDYYTHTAFELMMDNPNYDGAITTLCGGGRYNGLLELLDGPSETGIGFALSIERLLLALEEEGIELDIEENLDLFIVTMGDQADRYAVKLLNHLRHNGIKADKDYLQRKIKGQMKQADRLGAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIRE_HUMAN
Sequence: MATDAALRRLLRLHRTEIAVAVDSAFPLLHALADHDVVPEDKFQETLHLKEKEGCPQAFHALLSWLLTQDSTAILDFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPPPRLPTKRKASEEARAAAPAALTPRGTASPGSQLKAKPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQVFESGGSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLGQQGSVPAPLALPSDPQLHQKNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPARLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS
What is the function of this protein?
Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028).  Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box.  Binds to nucleosomes (By similarity).  Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'.  Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression.  Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028).  Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program.  Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression.  Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes.  In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection.  In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells.  Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity).
What are the official names of this protein?
Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, APECED protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly nuclear but also cytoplasmic (PubMed:11274163, PubMed:14974083). Found in nuclear body- like structures (dots) and in a filamentous vimentin-like pattern (PubMed:11274163, PubMed:14974083, PubMed:26084028). Associated with tubular structures (PubMed:11274163, PubMed:14974083).
Protein: ISPG_SALTI
Sequence: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQQVSVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRARGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNDDMIAQLESRIRAKVSQLDEARRIDVLQVEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: THA_MOUSE
Sequence: MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCPLKSSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHVATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLRGPVLQHQSPKSPQQRLLELLHRSGILHSRAVCGEDDSSEASSLSSSSDTEDTEVCEDQAGKAASP
What is the function of this protein?
Nuclear hormone receptor that can act as a repressor or activator of transcription.  High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.  Isoform Alpha-deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation.
What are the official names of this protein?
Thyroid hormone receptor alpha, Nuclear receptor subfamily 1 group A member 1, c-erbA-1, c-erbA-alpha.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [Isoform Alpha-deltaE6]: Cytoplasm. Note=Sequesters isoform Alpha-1 into this compartment. SUBCELLULAR LOCATION: [Isoform Alpha-2]: Cytoplasm. Nucleus. Note=When overexpressed found in the cytoplasm where it colocalizes with TACC1.
Protein: OPI8_YEAST
Sequence: MFFQPLNALSLCASLSSFSSSTLTSFAFISGTLSSFALCFNSMPFSSATLLISSSTLSLSTSMASEFTPISSYTLTLVSKSSNCCSNLSIIMVICWRFIFCNALSMPLQTCPIDADTCLIVTAVCTLDATESTRDANFNSCNLSFFFLIALDAYIRDISSFSLRARLSLLVSCFSSFEALLACFCNCFDVNFSWKRVFSKPAAELRDISQCDV
What are the official names of this protein?
Putative uncharacterized protein OPI8.
Protein: RPIA_AERPE
Sequence: MGGCDPMDEAARGALDLLGRIGGELGVLGVGTGRTVMRFLREASARGVEPGVAVPSSFETAVELAGLGWSVGDPRVYRGVNVYVDGADEAEPGRGYMVKGGGGALLGEKILSSRSKLNIFIVGEDRLVGRLGEKTPVPVEVEPGFVSMVLASLEELGLNPRVRTSPGKRGPVVSDWGGVIVDLLTGPLEDPRGLESMLRNVPGVRETGLFLGLADYIVVGLSSCGYRVLGPYRGRAV
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: 3S11_DEMVE
Sequence: MKTLLLILVVVTIVCLDLVCCSRTCCNQQSSQPKTTTVCPDGEKSCYKKSWRDHRGTRSERGCGCPTVKPGVNRECCDTDECNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin SNTX-1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.