PharMolix/UniProtQA huggingface dataset:
Protein: MDH_SHESR
Sequence: MKVAVLGAAGGIGQALALLLKTQLPAGSQLSLYDIAPVTPGVAVDLSHIPTAVEIKGFAGEDPTPALVGADVVLISAGVARKPGMDRSDLFNINAGIVRNLIEKVAVTCPKALVGIITNPVNTTVAIAAEVLKKAGVYDKNRLFGVTTLDVIRSETFIAELKGLNVADVKVNVIGGHSGVTILPLLSQVEGVTFSDEEVASLTKRIQNAGTEVVEAKAGGGSATLSMGQAACRFGMSLVRGLQGEANIVECAYVDGGSEHAEFFAQPVLLGKNGIEKVLPYGEVSAFEANARDSMLDTLKGDIKLGVDFVK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: DRC2_CHLRE
Sequence: MVKAGKKVKGASKVRENETEEEKKIRLEMEALAADEAERKAQEAARVALRERQLREQRYAHLNGIKIHNQWRKIMRMAKVEELRREIEILSQNHEREVDRKDAIMQMLDRDLEEAEEQYSLAVRSHMLVVDNLLDLQYQRMRALEAEFAADLKALEDEFETERTEIVNAHTRQRKDMGDMIAAMEGEFADAEAELRQEYEAQREEIKNRNSEEYNVLKIQLEGIIEELEKSFELAHRAYLESTEHRTNTFRTLTKDDAKAALKIERQMRKLVRLQEALQHWRTKIATNGREWEERNRALRNEKEIMARHYAKLKSSMDAFRAGQAERLKQLSLASSGAMETLRGKLAVAENVLKLAELARKYETEQEKVLPFWNPAQAVPSGEQGDEEAAAQAEAEAAALEPSAAELGELGLRASMPEDSSKEAPGPSKSSAGPGKPKFSSYGLDPSSGSEVDEWDYLNCFFRRYNKALLDKTAIDKEKSRLERENADLRSILKQYLDGISVNDDVLNNPVNPLLVVNNRLQITLTERNKARAAAMAQRAAAATGAGLSVTGQGAGGGGQKQLVEVQVVSRVS
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (PubMed:23427265, PubMed:25411337).  Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes.  Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:29167384).
What are the official names of this protein?
Dynein regulatory complex subunit 2, Coiled-coil domain-containing protein 65 homolog, Flagellar-associated protein 250.
What is the protein family that this protein belongs to?
Belongs to the DRC2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: ECHA_RAT
Sequence: MVASRAIGSLSRFSAFRILRSRGCICHSFTTSSALLSRTHINYGVKGDVAVIRINSPNSKVNTLNKEVQSEFVEVMNEIWANDQIRSAVLISSKPGCFVAGADINMLASCTTPQEAARISQEGQKMFEKLEKSPKPVVAAISGSCLGGGLELAIACQYRIATKDRKTVLGVPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLVDQLVDPLGPGIKSPEERTIEYLEEVAVNFAKGLADRKVSAKQSKGLMEKLTSYAMTIPFVRQQVYKTVEEKVKKQTKGLYPAPLKIIDAVKTGLEQGNDAGYLAESEKFGELALTKESKALMGLYNGQVLCKKNKFGAPQKTVQQLAILGAGLMGAGIAQVSVDKGLKTLLKDTTVTGLGRGQQQVFKGLNDKVKKKALTSFERDSIFSNLIGQLDYKGFEKADMVIEAVFEDLAVKHKVLKEVESVTPEHCIFASNTSALPINQIAAVSQRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDTTASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDALTTGFGFPVGAATLADEVGIDVAQHVAEDLGKAFGERFGGGSVELLKLMVSKGFLGRKSGKGFYIYQSGSKNKNLNSEIDNILVNLRLPAKPEVSSDEDIQYRVITRFVNEAVLCLQEGILATPEEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKVVDRLRKYESAYGTQFTPCQLLRDLANNSSKKFYQ
What is the function of this protein?
Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway.  The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA.  Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids.  Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity.  Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity.  It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP.  Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity.
What are the official names of this protein?
Trifunctional enzyme subunit alpha, mitochondrial, Monolysocardiolipin acyltransferase, TP-alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Protein stability and association with mitochondrion inner membrane do not require HADHB.
Protein: CARA_THET2
Sequence: MAGVKERAVLVLEDGTVYHGYAFGARGKTVGEVVFNTAQTGYQEIMTDPSYHGQIVVMTYPHQGNYGVNVYDMQSNRPWVRGFVAKEFSRVASNPRAQQTIGEFMEFYGVVGIEGIDTRALVRKIREGGVLKGTIAHASLFGAPDHAFTQEELEALRREAQAWTDIDGRDMTPEVSTPLPYAWPTLKSGRRIVVMDFGIKHAIVENLAALGFEVIVVPGKTPAHQIMALEPHGLLISNGPGDPTMPRYAHETIWKLMGLLPTFGICLGHQLLALAAGGRTFKMKFGHRGANHPVKNLQTGKIEITSQNHGYAVDIDSLKDFRPTHVNLNDGTLEGMAHARYPVFSVQYHPEAAPGPHDALYLFRRFLEEVEAFHGATGLPVEKQRADQHGI
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: TR49D_HUMAN
Sequence: MNSGISQVFQRELTCPICLNYFIDPVTIDCGHSFCRPCFYLNWQDIPILTQCFECLKTTQQRNLKTNIRLKKMASRARKASLWLFLSSEEQMCGTHRETKKIFCEVDRSLLCLLCSSSLEHRYHRHCPAEWAAEEHREKLLKKMQSLWEKVCENQRNLNVETTRISHWKDYVNVRLEAIRAEYQKMPAFHHEEEKHNLEMLKKKGKDIFHRLHLSKAKMAHRREILRGTYAELMKMCHKPDVELLQAFGDILHRSESVLLHMPQPLNLELRAGPITGLRDRLNQFRVDITLPHNEANSHIFRRGDLRSICIGCDRQNAPHITATPTSFLAWGAQTFTSGKYYWEVHVGDSWNWAFGVCNKYWKGTNQNGNIHGEEGLFSLGCVKNDIQCSLFTTSPLTLQYVPRPTNHVGLFLDCEARTVSFVDVNQSSPIHTIPNCSFSPPLRPIFCCVHL
What are the official names of this protein?
Tripartite motif-containing protein 49D, Tripartite motif-containing protein 49-like protein, Tripartite motif-containing protein 49D1, Tripartite motif-containing protein 49D2.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
Protein: RCF1_DEBHA
Sequence: MSRELPSSFDGKSEFDEDEMDILEKMAFKCKQQPLVPLGVIATTGAIFLATKSIRKGDRVNTQKYFRYRVGFQLATLIALVAGGYMFQVESDEQKATREEILRAKAKVRERLWIEELERKDEAMKSRKKRLEDSRAELIQAAKEGFEEEKKWTDAIENAKEEESAEGNDNKDVSN
What is the function of this protein?
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
What are the official names of this protein?
Respiratory supercomplex factor 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RCF1 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: RL16_PSELT
Sequence: MLMPKRVKYRKQQRGRMRGEAKGGTTVDFGEWGLKALAPAWITAQQIEAGRIAIMRVMKRSGKLWIRVFPDKPYTKKPAESRQGKGKGNVEGWVSVVKPGKIIFEIAGVDENTAKEALKYAASKFPIPTKIVSRSNIGGEAV
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RS18_SALNS
Sequence: MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: SBPN1_PINBN
Sequence: MDLISVLPSASKSCVCLHKPLSSSTHKLKPFCRTIRILGMPRPRKSVLMVSSMSISVNTLVSDDAVQRRTGGYHSNLWNDDVIQFLSTPYGELAYRERAERLIDEVRNIFNSMSLEDGEFSDLIIQRLWMVDNVERLGIDRHFKNEIKSALDYVYSYWSQKGIGCGTKSIITDLNSTALGFRTLRLHGYPVSADVLKHFRNQIGQFVSCPSETEEDIRSMVNLYRASLIAFPGEEVMEEAESFSEKYLKETLQKIPDCSLSREIGDVLEHGWHTNLPRFEARNYIDVFGQDTKNMESNRKTEKLLELAKLEFNIFQSIQKTELESLLRWWNDSGSPQITFTRHRHVEYYTLASCIAFEPQHSGFRLGFAKACHIITVLDDMYDLFGTVEELKLFTAAIKRWDPSATDCLPQYMKGIYMMVYNTVNEMSAEAQKAQGRDTLNYARQAWEVYLDSYVQEAKWIATGYLPTFEEYLENGKVSSGHRVSALQPMLTMDIPFPPHILKEVDFPSNLNDLACAILRLRGDTRCYQEDRARGEETSCISCYMKDNPGATEEDALNHLNVMISGVIKELNWELLKPDSSVPISSKKINFDITRAFHYGYKYRDGYSVSSVETKSLVMRTLLEPVPL
What is the function of this protein?
Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens (PubMed:23679205).  Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (-)-beta-pinene and, to a lower extent, to (-)-alpha-pinene (PubMed:23679205).
What are the official names of this protein?
(-)-beta-pinene synthase 1, chloroplastic, (-)-alpha-pinene synthase (-)betapin1, chloroplastic, Terpene synthase (-)betapin1, PbTPS-(-)betapin1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y673_SHEPC
Sequence: MEKIFERLMYASRWIMAPIYLGLSLVLLGLGIKFFQEIFHVLPIIFEMREVDLVLVTLSLIDITLVGGLIVMVMFSGYENFVSQLDVGEDSEKLSWLGKLDSGSLKNKVAASIVAISSIHLLKIFMNVENISNDKIMWYLLIHITFVLSAFAMGYLDKITRK
What are the official names of this protein?
UPF0114 protein Sputcn32_0673.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL36A_MOUSE
Sequence: MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
60S ribosomal protein L36a, 60S ribosomal protein L44.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL42 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_BURVG
Sequence: MKPVIALVGRPNVGKSTLFNRLTRSRDALVADLPGLTRDRHYGEGRVGERPYLVVDTGGFEPVAKDGILHEMARQTRQAVEEADVVVFIVDGRNGLAPQDKSIADYLRKTGRPIFLVVNKAEGMKYTAVATDFYELGLGDPRAISAAHGDGVTDMINEALEVAYAGQPEEADDNDPSRGIKIAIVGRPNVGKSTLVNALIGEDRVIAFDMPGTTRDSIYVDFERNGKKYTLIDTAGLRRRGKVFEAIEKFSVVKTLQSISDANVVILLLDAQQDISDQDAHIAGFVVEQGRALVIGVNKWDGLDDHARDRAKADLTRKLKFLDFAKSHYISAAKKTGIGALMRSVDDAYAAAMAKLPTPKLTRALIEAVEFQQPRRRGPVRPKLRYAHQGGQNPPLIVIHGNALDAVTETYKRYLENRFRETFSLTGTPLRIEFRSSNNPYADKG
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: MIAA_LEPBJ
Sequence: MILAAPTGAGKTSLVTELDPTRFEILSFDSRQIYKNMSIGTAAPTKKEQSKIAHHLVEVLSPSEAVDAGLYNRLAEEALQKVLNLDKIPVFTAGTGFYLKAFLFGMFPVPEIDVSVRDRVLSMSKEEKKNLLKELDPNALDKIFPEDDYRLGRALEVNLMGEKWSRLKIDPNTSAICRYDLDIRLGVFLDLDRKELYERINLRAKQMIEKGMADEAWKIQERFGETCPGLKSLGYNFALENKKGNSNLETFLADLSRSHRNYAKRQVTWFRKEPYVQPMGRSEALERIKHMK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: GSA_MYCLE
Sequence: MGSTDQATAPAGPAVSISAKLFEDACAVIPGGVNSPVRAFSAVGGTPLFITEARGCWLTDADGRRYVDLVCSWGPMILGHAHPAVVDAVATVAASGLSFGAPTPAETQLAAEIIGRMAPVERIRLVNSGTEATMSAVRLARGFTGRTKIIKFSGCYHGHVDALLADAGSGVATLSLPSSPGVTGAAAADTIVLPYNDIEAVRQTFARLGDQIAAVITEASPGNMGVVPPAPGYNAALRAITAEHGALLIIDEVMTGFRVSRSGWYGLDPVAADLFIFGKVMSGGMPAAAFGGRAEVMERLAPLGPVYQAGTLSGNPVAMAAGLATLRAAADAVYATLDRNADRLVAMLSEALTDAGVPHQIPRAGNMFSVFFSEAPVTDFASACNSQVWRYPAFFHALLDAGVYPPCSTFEAWFVSAALDDAAFGRIVDALPGAAAAAVAARHRES
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHC_CORGB
Sequence: MQSWPTPEVPALAGTPVPLELFDTADQEVRLVETPPAGSDTPVGMYVCGITPYDSTHLGHAATYLAFDLIYRILLDNDHDVHYVQNITDVDDPLFERAARDGVDWRDLGTSQINLFRSDMEALSIIPPKDYIGAIESIDEVIEMVKTLLDEGAAYIVEDAEYPDVYASINATDKFGYESNYDAATMAEFFAERGGDPDRPGKKNPMDALLWRAAREGEPSWESPFGAGRPGWHIECSAIATNRLGHSFDIQGGGSDLIFPHHEFSAAHAEAAHGVERMAKHYVHAGMISQDGVKMSKSLGNLEFVSRLTAAGHEPGAIRLGVFANHYRGNRDWNAESLATAEQRLATWREAARAATNREDAIAVVEQLRAHLSADLDTPGALAAVDNWAAGIDTTAGSKEFTEVGNIVVAAIDALLGVQL
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: RK22_ANEMR
Sequence: MDTTTSNPRIEASAKYIRMSPHKARRVVDQIRGRAYEQAPMILEFMPYRVCDSISQLLSSAAANANHNFGLSKTDLFIDAIQVDGGSFLKRIRSGARGRTYPIHKPTCHITIVMRMDSGWRNKISLRRFGK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, plastid.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid.
Protein: NPD_HELHP
Sequence: MPKLVVFSGAGLSAESGLETFRDNGGLWAQYDPMEVCNYENWLDNFELVHRFYNLRREELGKVQPNAMHKFLASLPMILNKPRIALSAKKKHKDPIEVIHITQNVDDLLERAGVSNVIHLHGELCKIICPQCEHIFDIGYTHFEPHNCPNCDYGKLKPFIVFFYERAPKYVIMHDIFSQLSSKDCVLVIGTSGNVVDISTILAFAESRARIGYKILNNLQYCPSIAESVFDKIFYKPTTQAIAEIEQELEQFFIS
What is the function of this protein?
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins.  Modulates the activities of several proteins which are inactive in their acylated form.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TLR4_BOVIN
Sequence: MMARARLAAALIPATAILSCLRTESWDPCVQVVPNISYQCMELNLYKIPDNIPISTKMLDLSFNYLRHLGSHNFSSFPELQVLDLSRCEIKIIEDDTFQGLNHLSTLILTGNPIQSLAWGAFSGLSSLQKLVAVETNLVSLNDFPIGHLKNLKELNVAHNFIHSFKLPEYFSNLPNLEHLDLSNNKIQNIYYEDVKVLHQMPLLNLSLDLSLNPLDFIEPGTFKEIKLNGLTLRSNFNSSHVMKTCIQGLAGLKTNRLVLGEFKNERKLQRFDRSFLEGLCNLTIEQFRIAYLDKFSGDDTDLFNCLANVSVISLLSISLGSLQALLKDFRWQHLEIINCDFDKFPALKLSSLKKFVFTDNKDISTFTEFQLPSLQYLDLKRNHLSFKGCCSHTDFGTTNLKHLDLSFNDVITLGSNFMGLEQLEHLDFQHSTLKQINAFSAFLSLRNLRYLDISYTNIRIVFHGIFTGLVSLQTLKMAGNSFQNNLLPDIFTELTNLTVLDLSKCQLEQVAQTAFHSLSSLQVLNMSHNKLLSLDTFLYEPLHSLRILDCSFNRIMASKEQELQNLPRSLTWLNLTQNAFACVCEHQSFLQWVKDQRQLLVGAEQMMCAEPLDMEDMPVLSFRNATCQLSKTIISVSVVTVLLVSVVGVLVYKFYFHLMLLAGCKKYGRGESIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKLEKSLLRQQVELYRLLSRNTYLEWEDSVLGRHVFWRRLRKALLAGKPQSPEGTADAETNPQEATTST
What is the function of this protein?
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:17559944).  Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate.  In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42.  In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36.  This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.  Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).  Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (By similarity).
What are the official names of this protein?
Toll-like receptor 4.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Early endosome. Cell projection, ruffle. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation.
Protein: SUV3_SCHPO
Sequence: MFLETLIHGVTFCVPFFSKSARIHTLSKDVFQQRKFPGNTLWAAALNRFTAYLFASKELSSKQAYLAQDFVNVCKDASVFQNVYYYELKKNILTDLGFSDLKNSDKSLALSKSSSTFDLQKIKKIHDCLLSEYRKYVRYQERIEETRPDLQKQLTDLKNPIEWYPGARKLRRHIIMHVGPTNSGKTHRALERLKTCKKGIFAGPLRLLAHEIYNRLQANGIACNLYTGEEIRNDYPFPQVVSCTVEMCNLSTTFDVAVIDEIQMMADPSRGYAWTQCLLGLQAKEIHLCGEESVVKLVRSIAKMTQDDFTVYRYERLNPLHVAEKSLNGKLSELKDGDCVVAFSRKNIFTLKSKIDQALGKKSAVIYGSLPPEVRNQQASLFNSKSSDENILLASDAIGMGLNLGVKRIVFSDLKKFSGVSTIDIPVPQIKQIAGRAGRHNPNGSKQSAGIVTTLYQKDFAKLNRAMNLPTKNLFNACIGAKDDLFFRYLSLFSDDIPQKLIFDRYFKLAKTTTPFVVSEGALSTFIIEYLDHIKGLTIKDKIKLLGCPVLKHSKYAPLFIREIGCVIAQGKRLQIYDLKSVPLEILERGIPTTETELQQLEQLHKLIVAYMWASIRYPAILQNGAAEKTKAIAEAFLIKGISKLQK
What is the function of this protein?
Required for intron-independent turnover and processing of mitochondrial RNA.  It is a key control element in nuclear-mitochondrial interactions (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase suv3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: HS105_RAT
Sequence: MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEDHLFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNADEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPLHLLMEQTHLKTEEVSAIEIVGGATRIPAVKERIARFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQAVPYPEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSVEADMECPNQKPAESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPRVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLHQDPVVRTHEISAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNMDKKEDLEGKSNLGADAPHQNGECHPNEKGSVSMDLD
What is the function of this protein?
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release.  Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly.  Inhibits HSPA8/HSC70 ATPase and chaperone activities.
What are the official names of this protein?
Heat shock protein 105 kDa, Heat shock 110 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUB2_ARTBC
Sequence: MQLLNFGLLLLPFVAGDLAPQPEPLLAGPSDVVPGQYIVTLKEGLTSAQIRDHKKWVSSVHRANLDSFAAGASGVETEGIMKHFHIHDLNMYSGGFDEKTVEDLSRNPYVKSVHPDQHVYLAKTVTQRQARWGLGYMSSKGKPVPLHSTLVDYSYDDKAGEGVWAYVLDTGINVNHVEFEGRGILGHNAIPNKPHTDEFGHGTYVAGIIAGKTYGVAKKANVVSAKAFDTGSSTYNYILETYDWIVRNITDSNRKNKAVINLSISGAKYQPFDDAVEKAFKAGITTVVAAGNDGKDAKNNTPASSPNAITVGAVRWENTRPSFSNYGKLVDIWAPGELIKSCWKGGNNATSTQSGTSAASPHVAGLVAYLMSIENLPSPSAVTARVLNLTIPNLVKDAKDSPNRVAYNGIQERKFTLPKYY
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MUTH_SALCH
Sequence: MSALCPLLTPPASEALLLAQARQLSGYTLGELAAMAGITTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEELMDMIVLGQVERITARHGEVLQLRPKAANSRALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_THEP3
Sequence: MKLYNTLSRTKEEFEPLNDKIVNMYVCGPTVYNYIHIGNARAFIVFDTVRRYLEYKGYKVNYVQNFTDIDDKIIKRAQEENVTTKEVAEKYIEEYFIDADNLGIKRATVHPKATEHIEDIIEFIKILIDKGYAYVVNGNVYFETAKFKDYGKLSHKNIEELQAGARIEINEEKKNPLDFVLWKAQKPGEPAWDSPWGKGRPGWHIECSVMSTKYLGKTLDIHAGGPDLVFPHHENEIAQSEAAYGQPFSKYWMHIGYLNINNEKMSKSKGNFFTVREITEKYNPEVLRLFMLMAHYRSPINFSLDLMEQAKSAYERLLNAVANLKHLLTVCKDRELNEEEKRIKEKFEEYKKEFEDAMDDDFNTADAISVLFEMSKTANTNISGNSSKKLVEYILDIFLKLSEILGLSYRGVETELNDEEILALIEERQKARKEKNWKLADEIRDRLREKGIILEDTPEGVRWKRV
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_ECOL5
Sequence: MIKKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAIENMKRPFKGDWLDCAKKLY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase isozyme 1, ATP-PFK 1, Phosphofructokinase 1, 6-phosphofructokinase isozyme I, Phosphohexokinase 1.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.