PharMolix/UniProtQA huggingface dataset:
Protein: SYT_EHRCR
Sequence: MINIHFSNNLCKQFHRGIKGHDIVNDLFPKLKNETIAAKVNGELYDLSREIIENCTFEVITINSEEGLEIIRHDTAHIMAQAVKEMFPDVQITIGPTIKDGFYYDFATNHNFSSDDLEIIEKKMIEIINKNESFIREVWSREEAIKFFSSIGEDYKVKIISNIPSNENITVYKQGSFTDLCRGPHAPSTKTSRAFKLTKVSGSYWQGNSNNERLQRIYGTAWRNEEELKLYLNNLIEAEKRDHRKIGRELELFHIQNEACGQIFWHTKGWTIYRIIENYIRKKLENNGYIEVKTPILLNKELWEKSGHWDKFRENMFLSEAEDKTLAIKPMNCPCHIQIFNSKIRSYRDLPIRMAEFGTCHRYEASGALHGLMRVRGFTQDDAHIFCTESQITSEALKFCNLLIEIYKDFGFTDILVKFSDRPKNRAGSDEIWDKAEAALKKSVEVANLSYVLNPGDGAFYGPKLEFTLKDAIGREWQCGTLQMDFVLPERLGAYYIGSDGKKHHPVMLHRAILGTFERFIGILIEHHSGKFPMWLAPIQLSILTISEDSINYANSLKIKAEEHNIRVELDTTNEKINYKIRNHIHKKVPVFWIVGKKEVEENSVSIRYLESNKQHVMPIDKALKTLLTCASI
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSD_YERPN
Sequence: MDEKRLTHLRQLEAESIHIIREVAAEFGNPVMLYSIGKDSSVMLHLARKAFFPGHLPFPLLHVDTGWKFREMYEFRDHTVKEFGCELLVHRNPEGVAMGINPFVHGSAKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINKGESIRVFPLSNWTELDIWQYIFLEKIEIVPLYLAKPRPVVERDGMLLMVDDDRIDLQPGEVIVQKKVRFRTLGCWPLTGAVESEAETLPAIIEEMLISTTSERQGRMIDRDQSGSMELKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: LHB1_HALHR
Sequence: ANDIRPLRDFEDEEAQEFHQAAVQAFFLYVAVAFVAHLPV
What is the function of this protein?
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
What are the official names of this protein?
Light-harvesting protein B800/830/1020 beta-1 chain, Antenna pigment protein beta-1 chain, EHS-beta-1.
What is the protein family that this protein belongs to?
Belongs to the antenna complex beta subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: MCP_PONAB
Sequence: MAPPGRRECAFPSRRFPGLLLAALVLLLSSFSDACEEPPTFEAMELIGKPKPYYDIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIGDPLNGQAILANGTYEFGYQIHFICNEGYYLIGNEILYCELKGSVAIWGGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSHAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLNGSNTIVCDSNSTWDPPVPKCLKGYPKPEEGILDSLDDWVIALIVIAIVVGVAVICAVLYGYLQRRKKKGNADGGAEYATYQTKSTTPAEQRG
What is the function of this protein?
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue.  May be involved in the fusion of the spermatozoa with the oocyte during fertilization.  Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.  T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).
What are the official names of this protein?
Membrane cofactor protein.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa.
Protein: PSBI_NOSP7
Sequence: MLTLKIAVYIVVAFFVTIFIFGFLSNDPARNPGRRDLE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.4 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RS2_STAHJ
Sequence: MAVISMKQLLEAGVHFGHQTRRWNPKMKKYIFTERNGIYIIDLQKTVKKVEEAYNFIKQVSEDGGRVLFVGTKKQAQESVKAEAERAGQFYVNQRWLGGILTNYKTISKRIKRISEIEKMEEDGLFDVLPKKEVVELKKEYDRLIKFLGGIRDMKSMPQALFVVDPRKERNAIAEARKLNIPIVGIVDTNCDPDEIDYVIPANDDAIRAVKLLTGKMADAVLEGQQGVSNDEVAAEQNINLDEKEESQEAESTEENTTVESN
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: EFPL_CITK8
Sequence: MPRANEIKKGMVLNYNGKLLIVKDIDIQSPTARGAATLYKMRFSDVRTGLKVEERFKGDDIVDTVTLSRRGVDFSYIDGNEYVFMDKEDYTPYTFTKDQIEEELLFIPEGGMPDMQVLTWDGQLLALELPQTVDLEIVETAPGIKGASASARNKPATLSTGLVIQVPEYLSAGEKIRIHIEERRYMGRAD
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: NUSA_ECOLI
Sequence: MNKEILAVVEAVSNEKALPREKIFEALESALATATKKKYEQEIDVRVQIDRKSGDFDTFRRWLVVDEVTQPTKEITLEAARYEDESLNLGDYVEDQIESVTFDRITTQTAKQVIVQKVREAERAMVVDQFREHEGEIITGVVKKVNRDNISLDLGNNAEAVILREDMLPRENFRPGDRVRGVLYSVRPEARGAQLFVTRSKPEMLIELFRIEVPEIGEEVIEIKAAARDPGSRAKIAVKTNDKRIDPVGACVGMRGARVQAVSTELGGERIDIVLWDDNPAQFVINAMAPADVASIVVDEDKHTMDIAVEAGNLAQAIGRNGQNVRLASQLSGWELNVMTVDDLQAKHQAEAHAAIDTFTKYLDIDEDFATVLVEEGFSTLEELAYVPMKELLEIEGLDEPTVEALRERAKNALATIAQAQEESLGDNKPADDLLNLEGVDRDLAFKLAARGVCTLEDLAEQGIDDLADIEGLTDEKAGALIMAARNICWFGDEA
What is the function of this protein?
Part of the processive rRNA transcription and antitermination complex (rrnTAC).  The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP).  It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis (PubMed:32871103).  Participates in both transcription termination and antitermination.  Involved in a variety of cellular termination and antitermination processes, such as Rho-dependent transcriptional termination and intrinsic termination (PubMed:31020314).  Domain AR2 interacts with a large number of other proteins and may serve as a platform to recruit these factors for transcriptional regulation (PubMed:31127279).  Involved in phage lambda N-mediated transcriptional antitermination.  Also important for coordinating the cellular responses to DNA damage by coupling the processes of nucleotide excision repair and translesion synthesis to transcription.
What are the official names of this protein?
Transcription termination/antitermination protein NusA, N utilization substance protein A, Transcription termination/antitermination L factor.
What is the protein family that this protein belongs to?
Belongs to the NusA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Colocalizes with nucleoids.
Protein: MATK_LABPU
Sequence: MEQYQAYLELRRSRYQDILYPLFFRESIYGLAYGHESFFTENVDYNNKFSLLIXQRXSTRMYQQTHFSLCANDSNKNTFVGYNYNFDSQIILEGFGVVVEILFSLQLFISSLRGLEIVKSYQNLQSIHSIFPFFEDKLIYLNHKSDIRIPYPIHLEIXXXXXXXXXXXXXFFHLIRLFFYYYYNWNSLFPPKKRISTFFSKRNLRIFLFLYNLYVWEYESIFLFLRNKCSQLQLKHFLVFFERIFFYEKRKHLVEVSTKTCSYTLFFFKDTFIHYVRYKGKSILVLKNTPLLINKWKYYFIYLWQCHFDIWAGPGTIYINQLSQXSFHFLGYFLSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXANFSDFDILDRFLRICRNFSHYYNGSAKKKSFYQIKYILRFSCIKTLARKHKSTVRTFLKKLSSEKLLEEFFTEEDLFSLIFPRTSFTLRGVYRGRIWYLDIFFRNDFVNHF
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y030_SULIM
Sequence: MIKEYYGAETFILNKDFAYILVIGTTDVSLIPGLTIAGATPELTHFTPAADAEYVLLGKCKSINTIPVSPTGIPTPALLTRASLSFINPLKIVVNAGSRILPKIPYIDLQGEPGKDIRKQALSMEKVNNIIENSIKLGEELSNEYELIMIGESIPAGTTTAMATLLALGYDAMDKVSSASPDNPKELKRKVVEEALRNLPTDPLQRLAKVSDPVLLGVAGTSLGFKGKILLAGGTQMTAAAAIINEFDKNKLKDITIGTTKWIVEDKFADMLSLAKQVGVKVLASMLDLSISAYEGIRAYEKGYVKEGVGAGGSAIMALVKGVSNNTLVRKIDELYGELVGSSNLHI
What are the official names of this protein?
UPF0284 protein M1425_0030.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: Y2175_MYCTU
Sequence: MPGRAPGSTLARVGSIPAGDDVLDPDEPTYDLPRVAELLGVPVSKVAQQLREGHLVAVRRAGGVVIPQVFFTNSGQVVKSLPGLLTILHDGGYRDTEIMRWLFTPDPSLTITRDGSRDAVSNARPVDALHAHQAREVVRRAQAMAY
What is the function of this protein?
Binds DNA at low salt concentrations.
What are the official names of this protein?
DNA-binding protein Rv2175c.
Protein: CAV2_FELCA
Sequence: MGLETEKADVQLFMDDDSYSRHSGVDYADPDKFADSGSDRDPHRLNSNLKVGFEDVIAEPVSTHSFDKVWICSHALFEISKYVIYKFLTLFLAIPLAFAAGILFATLSCLHIWIIMPFVKTCLMVLPSVQTIWKSITDVVIAPLCTSVGRSFSSVSLQLSHD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Protein: BETA_STAAB
Sequence: MSNKNKSYDYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDYFWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVAHARGKVLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGAAPYDKFRGHDGPIKLKRGPATNPLFQSFFDAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTYKKNGKLHTIDANEVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLDIKRMPFIGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRYDGQKAAVAHGYQVHVGPMYSNSRGSLKIKSKDPFEKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEILDWVRRDGETALHPSCSAKMGPASDPMAVVDPLTMKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPLEPQYIDYYKHGVHDENEGAIEVKPYAK
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: LPXK_PSYIN
Sequence: MPFWYRPVTWAWLLLPLALLFKMISFCRRLAYQKGFFKRYKSKLPVIIVGNISVGGNGKTPFVIWLCEMLITVGYKPAVISRGYGGKSNHYPLLVGDHIKGHEAGDEPVLIHKRLGIPVVVDPNRKNAVKYIEQHFLADIIISDDGLQHYALQRDIEIVIVDGKRRFGNQHLMPIGPLRENLSRLNSVDFVVNNGGQQVNEITMLLKAQNCQRVDGETAQLSSGVQVNACAAIGYPQRFFDTLNQQQFEILKAVGFNDHHAFSKDDFTQFEASIPLLMTEKDAVKCTDFAQPNWWYLPVSAEFSAGFEQQLLNRIKEIKC
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: ARNE_SALPK
Sequence: MIGIVLVLASLLSVGGQLCQKQATRPLTTGGRRRHLMLWLGLALICMGAAMVLWLLVLQTLPVGIAYPMLSLNFVWVTLAAWKIWHEQVLPRHWLGVALIISGIIILGSAA
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE, L-Ara4N-phosphoundecaprenol flippase subunit ArnE, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE.
What is the protein family that this protein belongs to?
Belongs to the ArnE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y436_STAAM
Sequence: MRYLKRLSWYISILILIVVIAGCGKGNETKEGSKEEQIKKSFAKTLDMYPIKNLEDLYDKEGYRDSEFKKSDKGTWTIYTDFAKSNKPGELDDEGMVLNLDRNTRTAKGHYFVTTFYRNGKLPDEKNYKIEMKNNKIILLDEVKDDKLKQKIENFKFFGQYANLKELRKYNNGDVSINENVPSYDVEYKMSNKDEIVKELRSRYNISTEKSPILKMHIDGDLKGSSVGYRKLEIDFSKRENSKLSVIEFLSYKPAKK
What are the official names of this protein?
Uncharacterized lipoprotein SAV0436.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: UPPP_TROW8
Sequence: MVLEAVLLGIVQGITEFLPISSTAHMYILAKLLNLHVPGRFFLSSVQLGTSFALILYFFKDVKGIISETSRSIYSFIQFGIRQKQEKRNEYTRLGLLLVTGTIPVVLLGFLLVRFVPDGFFSAARNLFTMGVALIVFGLLLGFADALFRRKKGNIFQITFIESVLIGAAQIFAIIPGVSRSGITITTARFLNFDRQLAVRFSFLLSLPVTFIGGMYGLVAGPDTDYYSLGYSLIGAIVSFVVGLLVVSALLRIISKTTFVLFVYYRVLFGLFLVIVSFF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSBD_PROMM
Sequence: MTIAVGRAPQRGWFDVLDDWLKRDRFVFVGWSGLLLFPTAYLALGGWFTGTTFVTSWYTHGIASSYLEGCNFLSAAVSTPADAMGHSLLLLWGPEAQGDFVRWCQLGGLWTFVALHGSFSLIGFMLRQFEIARLVGIRPYNALAFSGPVVVFLACFLIYPLGQHSWFFAPSFGVAAIFRFILFLQGFHNWTLNPFHMMGVAGILGGALLCGIHGATVQNTLFEDGAMSNTFKGFDPTQEEETYSMVTANRFWSQIFGIAFSNKRWLHFFMLFVPVMGMWTPSVGIVGLAVNLRAYDFVSQEVRAAEDPEFETFYTKNVLLNEGIRAWMSVADQPHENFVFPEEVMPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: RBFA_BLOFL
Sequence: MYTKRINRLQRISQEIQRKVAIIIHHKVHDPRVGLPTISGVQVSRDLKNAKIFITFLDKNNIEEINFSILILQKASGFIRFLLANSMNLRTVPVLLFKYDYSLKEGIKICKLISQLK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXC_ECO81
Sequence: MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: MOB3B_MOUSE
Sequence: MSIALKQVFNKDKTFRPKRKFEPGTQRFELHKRAQASLNSGVDLRAAVQLPNGEDQNDWVAVHVVDFFNRINLIYGTICEFCTERTCPVMSGGPKYEYRWQDDLKYKKPTALPAPQYMNLLMDWIEVQINNEDIFPTCVGVPFPKNFLQICKKILCRLFRVFVHVYIHHFDRVIVMGAEAHVNTCYKHFYYFVTEMNLIDRKELEPLKEMTTRMCH
What is the function of this protein?
Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
What are the official names of this protein?
MOB kinase activator 3B, Mob1 homolog 2b, Mps one binder kinase activator-like 2B.
Protein: FTSB_SHEON
Sequence: MKFFVITLIVLLGLLQYRLWSGDNSLPEYFVLQKQIAAQQDGNAKLNERNQVLKEEIIDLKSGTEAIEERARNELGMVKEGETFYRVVGGDRAVSSPSQ
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: G137A_MOUSE
Sequence: MESNLSGLVPAAGLVPALPPTVTLGLTAAYTALYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCPVCLQFFTLTLMNLYFVQVVFKAKAKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSRQRQAQPWVLLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAIGGAMVLLYASRACYNLAALALAPRSRLDAFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSRILNGQVFGSRSYFFDRAGHCEDEGCSWEHSRSESTSMSGSLGSGSWYGAIGREPGWGGASQTRTTPLLFSQVPGPGSHHHSLYSTPQT
What is the function of this protein?
May activate Wnt/beta-catenin signaling to modulate epithelial cell function.
What are the official names of this protein?
Integral membrane protein GPR137, Transmembrane 7 superfamily member 1-like 1 protein.
What is the protein family that this protein belongs to?
Belongs to the GPR137 family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: IFNG_PERMA
Sequence: MNATCCILALLLCLTQAISGCYCQGTLIEEIENLKKHFNSSSSDVGDGGELVLDIWRNWQKDGDIKIIESQIISFYFKLFDALKDNQAIQESIGTIEQDLLVHFFNSSEEKRDDFMKVMKIPVDDPQVQRKAVNELLGVMYRLSPKNSLRKRKRSRCCFGGGARPNKNNAASKTI
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: GCSPA_SACS2
Sequence: MYKHPWLPNLDLTDEMLKEIGVNSLDDLFNDIPAEIKINRLLKVAKDKPLSEYEIEKEIYEKVKKNVELEAPPFIGAGICPHYIPNAVKFIIGRSEFYTSYTPYQPEISQGILQALFEYQSLMAELLEMDVVNASMYDWGSALAEAVLMANRINGKKTVLVPENANPFHKEVMRTWIQGKGIKIEEVKYDKNSGEVDIEDLEKKSSSNDVSAIYVQQPNFFGIFESNIEHIIDVAKHKKALSIIGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGIFAVRWDMGLVRQMPGRIVGITRDVNNNMGFTLILQTREQFIKREKATSNITTNEALLALANAVYLSLLGKEGIRELAEEIYFRSHYAAKRLTEIDNVIMPFTSDFFEEFVIKFPIEYNIINDKLKERKLQGGLKLSIHTSLFCVTEVHDKKSIDLLVSTIQEAIKSVETS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: BIOB_MARN8
Sequence: MTATATRHDWTLQEARELFNLPFNDLLFRAQSIHREHFDPNEVQVSTLLSIKTGACPEDCKYCPQSGHYNTGLEKEKLLEIEKVVAEARVAREKGASRFCMGAAWRSPSKKDMPYVLDMVRQVKSLGLETCMTLGMLKEEEAKELADAGLDYYNHNLDTSEKYYNHIITTRTYQDRLDTLDNVRKAGMKVCCGGIMGMGEDEDDRVGLLVQLANLPQHPESVPVNMLVKVKGTPLEDVEDLDPFDFIRIIAVARIMMPASHVRLSAGREQMNEQMQALCFMAGANSIFYGEKLLTTSNPEADADMQLFRKLGIRPEQREQCATEEQEEEAIAEAVEYEATRHMFYDATRESA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RNFH_ECO7I
Sequence: MPGKIAVEVAYALPEKQYLQRVTLQEGATVEEAIRASGLLELRTDIDLTKNKVGIYSRPAKLSDTVHDGDRVEIYRPLIADPKELRRQRAEKSANK
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.