PharMolix/UniProtQA huggingface dataset:
Protein: RL9_STRE4
Sequence: MKVIFLVDVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEASSQAIGQLRGQQKAEEKAQAEILAEAKAVKKILDDEKTRVQFKEKVGPDGRTFGSITAKKISEELQKQFKVKVDKRHIVLDHPIRAIGLIEVPVKLHKEVTAEIKLNIAEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: NNMT_HUMAN
Sequence: MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL
What is the function of this protein?
Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:8182091, PubMed:21823666, PubMed:23455543).  Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases.  Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (PubMed:26571212, PubMed:23455543, PubMed:31043742).  In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (PubMed:26571212).  Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis.  In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity).  Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity).  Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (PubMed:30044909).
What are the official names of this protein?
Nicotinamide N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_CUPTR
Sequence: MSDDKRAKSDKNEKNKYPVNLLDTPFPMRGDLPKREPQWVKQWQDKQLYKKIRAARKGAKKFVLHDGPPYANGDIHIGHAVNKVLKDMIIKARGLTGLDAVYVPGWDCHGMPIEIQIEKKFGKGLPVQEVQAKARAYATEQIKRQMVDFERLGVLGDWDHPYLTMNYRNEADELRALGKIMEKGYVFRGLKPVNWCFDCGSALAEAEVEYKDKVDLSIDVGFPFAEADKLAHAFKVPVEQIDARPGWIVIWTTTPWTIPSNQALNVHPEVEYALVDTPRGHLILATERVEEQLKVYALEGKVIATATGAALSEIRFHHPLAKMDGGYDRLSPIYLGDYVTTDTGSGIVHSAPAYGVEDFQSCKAHGMPDSDIISPVMGNGVYAGTLPLFGGLSIWDANPRIVEALQESGNLFNSHKYTHSYMHCWRHKTPIIYRATSQWFAGMDVDPAEENGKPVPTLRETALAGIDATEFYPAWGKQRLHNMIANRPDWTLSRQRQWGVPMAFFVHKETGALHPRTPELLEAIAKRVEQQGIEAWQTLDPAELLGDEASQYEKNRDTLDVWFDSGTTHWTVIRGSHRDDLYDPSADEADGRLADLYLEGSDQHRGWFHSSLLTASMLYGKPPYKALLTHGFTVDGEGRKMSKSIGNTVSPQDIANKMGAEIIRLWVASTDYSGELSISDEILKRVVESYRRIRNTLRFLLSNLSDYDHGKHALPAAEWLEIDRYAVALTAQLQKEVLSHYEAYEFHPVVAKLQTFCSEDLGGFYLDVLKDRLYTTAPDSKARRAAQNALYHITQAMLHWMAPFLSFTAEEAWQVFAHGTAHTDTIFTSTYYAVPEVDDADDLLQKWHTLREVRAEVTRQLEAVRVEGEIGSSLQAELTIQAGGPVLEALQSLGDDLRFVLLTSAAKVTAAPEAGDLLVTVTPSAHAKCERCWHYRADVGHNPDHPTLCGRCDSNLFGAGEHRSHA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDUB_DICDI
Sequence: MKFIKYLLILFLILKINYFVESGVDCQKNTEYFVENSCGKNPSKLNINTDIYYFESIGITPYSPPVYNESTTNYFWYLKDGIEYTFSYRYKGCQNIKSHSIVSQGMYYQLLSQPLCPNTYFNYTIYNSGEFGGNTNYYSTPQNIISSNYNGSCTINILITPLSNSKGAFQSSAAKYTYPTCGFNNGTISVDLTKGYSNCHLFSQFDTSFLYEIEPSSPCFYSGLESNYYYLFVDSKECATERLSIQLFNVFTPLEITFENVPDYNQNSIVSLSLSSGDNGILNKTNSFATVGGTGPDPLSTWSHKETKITSTTQFGYFYNKDFSTDPLKVICSFNDGFEPQKFNPNFNFTVTKSDTCLENVTITFYPLPSQTFVVHDYILGNILPLTNNVLSVQYNKFLHISEISSNSERYYSTAFYAPIYRVVETSNGIGCWKTYNITIGEYQIYSNLTMKVYDGDEYEYIFYPIEGVFVNVPANYFYIHYKVKDCEVESIIMIDKYEEITPMDDVKMDISIYELGNCTHETSILVNIDTVFGNFSKVYSSFSNGYFSFYLPNCSCNIGFYYSIPPLIDSETFSYGFISDLDCNSTGTVIQLLGSNGNTIQEVYSNGIKLIVNNDVDTDFAYNIGPGENNVTIKYSNTKGTCYKSQMINIQSPYEVPLVEVTPVIDCDSSDGKISISNYMNFYSLDIIIDSSTIPINSGLVSNLPTGTYTIVYGNSGSCANSIDVYVPSSEQYVEITTSVISHPTCGEQSLNGDGKVNVTLKVLGIKKNTFYIQNQNQISSLTFSDGGVYIAAAPGLNTLSISYGGCIWNRDVNTTISKPTFSFEKIYNDTCLSSVYYKLINNNTNIAINSITSPYTLYSYQNEYYTQMATNLIYPYTVTWNTYCTETFYQEFTFDTPFNYYSNYIQYEIVKADNCNSFKIDIIIKNMNTFQKVTLSSKYPTPINSTHAIFKNLPPSISYDISFTLFDGCSGTEMVGYQQLSNGNTKETIDIIKVNDICNSGKGSIQLSNMDTSNHYYYVKTFSDYYVYTSYPIQPTTNDNGTIISLLSNLPVGSYNITRNCKSITNCYIETKVVIENKDPIIESISVTDSYDKLNNGTAEIKLNYNSTYPINFKIIGTQLSNQNGIFSNLPPKTYEVQVTLTDRMCPITISQSFTINFKTSPTPPPLPQDPSDELSTSSFIQLNILSLLLISIFTIFIL
What are the official names of this protein?
Protein dduB, Down-regulated in dupA mutant protein B.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: BETA_ECO24
Sequence: MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEGDSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGTECQTDEQLDEFVRNHAETAFHPCGTCKMGYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRSTAGYFVANGMPVRAKK
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: PANC_BACC2
Sequence: MKIVTTVQEMQQITNELHASGKSIGFVPTMGYLHEGHATLLRKAREENEIVVLSVFVNPLQFGPNEDLDRYPRDIDRDENVAKENGVDYLFYPSVEEMYPSEQTTTVEVVKRTDVLCGKQRPGHFAGVATVLMKLFNITLPTRAYFGMKDAQQVAVIEGFVTDFNIPVTIVPVDIVREEDGLAKSSRNVYLSQDEREEALHLYRSLCIAKERIEAGERNPEIITNLVKEYIETHTKGTVDYADLYAYPSLTMVEKVEGRIILAIAVKFENVRLIDNITLTVK
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNY2_LEVBA
Sequence: MLITGLIIGCLLIGLVIGYVVRQHQHRQELLAVQKQARDIIASATAETQQKIAKLTADSRRETLTYQQSVKDELAEQTSDIAVREQRRQQREQLLGQMGVRLADQTAILDERSQANRDQRQKIRDLKAQALQLRTDRDEMLAQQAGIDEQAAKDHVLADTELDLKRDRDVEIKALNDNAVANAERWAKDVVLSATESGPQDLPKEHLEHTVTVPNGEIRSKIIGRDGQHIRLLETLTGTDLIFVPDDNTTLFISTHDPIRREVARVALTNLVASRRISSNQIETQVENAQRDVNHSLWETGEQTVSGLHVGWMHPDLMKLIGRLKYRTSYGQNVLLHSIEVAQLTGAMAARLGYNTRLARRAGLLHDLGKAIDHEVEGTHVEIGTEFAQKYGEDDVVINAIAAHHGDVEKTSPLAELVAAADAISGARPGARSESVEDYINRLRALEKIANDQSGVAESYAIQAGRELRIIVKPQELDDTAAANLTQEVAQQIESTLTYPGKIKVTTIRKSTAVEYVGDEKKKKSKKKKKKAANA
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y 2, RNase Y 2.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SFP47_SCHPO
Sequence: MNSFSSNEYSTEISTEALNNWQQLVEQRISLELEYAAKLAKLTKSIKAIKQCAPLNDLTKQVCVELMQCNKKHLEASRYFQTHVKEFMKEYVDRENKFSNETISKSSAAALMTSMENFILFTNPVYHNKLQVPSKSDMEIANSLKITQPAEKNSGTANPISAYSLEHAELDERNNQLSEALSMLRLSPFVNNYYPSYQNRKDGKSLMENRGVVLSVDTVTSPISQSPKKLTPTTSPINSTSLSFVDAKKPGSKWPSQYDFPKKTKSTEIPFKTLPSLNINNERELTKHKLPIVKPKLAVFPSNQATASTLQLAPPPVQAIPTLRNPVNLDDKKESLLKYYATHPTITPDGFPIFAYVRALYAYKATLPSEIDLNVDDTLVVLNRQKDGWWKGLVVSPTVGRIGLFPSNYIEELEY
What is the function of this protein?
Required for the regulation of activity and recruitment of ubp4 to endosomes.
What are the official names of this protein?
Ubp4-interactor sfp47.
What are the subcellular locations of this protein?
Cytoplasm. Endosome.
Protein: SCPDL_RAT
Sequence: MATEQRPFQLVVFGASGFTGQFVTEEVAREQMASEQSSRLPWAVAGRSKEKLQQVLEKAAQKLGRATLSSEVGIIICDISNPASLDEMAKKATLVLNCVGPYRFYGEPVVKACIENGTSCIDICGEPQFLELMHVKYHEKAAEKGVYIIGSSGFDSIPADLGVLYTRNQMNGTLTAVESFLTINSGPEGLCIHDGTWKSAIYGFGDKGSLRKLRSVSNLKPVPVIGSKLKRRWPVSYCRELNSYAIPFLGSDMSVVKRTQRYLHENLEDSPVQYAAYITVGGITSVIKLMFAGLFFLFFVKFSIGRQLLVKFPWLFSFGYFSKRGPTQKQMDESSFTMTFFGQGYSHGVSAEKNKPNIRICTQVKGPEAGYVATPIAMVQAAVTFLNDASDLPKGGGVFTPGAAFSRTKLIDRLNQHGIQFSVISSSEV
What are the official names of this protein?
Saccharopine dehydrogenase-like oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the saccharopine dehydrogenase family.
Protein: IL1A_CANLF
Sequence: MAKVPDLFEDLKNCYSENEEYSSEIDHLSLNQKSFYDMSCDPLHEDCMSLSTSEISKTSQLTFKENVVVVAANGKILKKRRLSLSQFITDDDLEGIANDTEEVIMKPRSVAYNFHNNEKYNYIRIIKSQFILNDNLNQSIVRQTGGNYLMTAALQNLDDAVKFDMGAYTSEDSKLPVTLRISKTRLFVSAQNEDEPVLLKEMPETPKTIRDETNLLFFWERHGSKHYFKSVAQPKLFIATQERKLVHMARGQPSITDFRLLETQP
What is the function of this protein?
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems.  After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex.  Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.  In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways.  Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.  In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
What are the official names of this protein?
Interleukin-1 alpha, IL-1 alpha.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Recruited to DNA damage sites and secreted after genotoxic stress.
Protein: GEMI4_HUMAN
Sequence: MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHMEVCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQIRQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGPNSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.
What are the official names of this protein?
Gem-associated protein 4, Gemin-4, Component of gems 4, p97.
Protein: SPS2L_HUMAN
Sequence: MAELNTHVNVKEKIYAVRSVVPNKSNNEIVLVLQQFDFNVDKAVQAFVDGSAIQVLKEWNMTGKKKNNKRKRSKSKQHQGNKDAKDKVERPEAGPLQPQPPQIQNGPMNGCEKDSSSTDSANEKPALIPREKKISILEEPSKALRGVTEGNRLLQQKLSLDGNPKPIHGTTERSDGLQWSAEQPCNPSKPKAKTSPVKSNTPAAHLEIKPDELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAAFAELHNCIIDKEVSLMAEMDKVKEEAMEILTARQKKAEELKRLTDLASQMAEMQLAELRAEIKHFVSERKYDEELGKAARFSCDIEQLKAQIMLCGEITHPKNNYSSRTPCSSLLPLLNAHAATSGKQSNFSRKSSTHNKPSEGKAANPKMVSSLPSTADPSHQTMPANKQNGSSNQRRRFNPQYHNNRLNGPAKSQGSGNEAEPLGKGNSRHEHRRQPHNGFRPKNKGGAKNQEASLGMKTPEAPAHSEKPRRRQHAADTSEARPFRGSVGRVSQCNLCPTRIEVSTDAAVLSVPAVTLVA
What are the official names of this protein?
SPATS2-like protein, DNA polymerase-transactivated protein 6, Stress granule and nucleolar protein, SGNP.
What is the protein family that this protein belongs to?
Belongs to the SPATS2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=During oxidative stress as well as UV irradiation, energy deprivation or heat shock, relocalizes to cytoplasmic stress granules. In the nucleus, found in structures lacking NPM1.
Protein: SFSA_PYRAR
Sequence: MYFPLEEPDAYGDFVRRLNRFAGIAVIGGREVKIHIHDPGRLQELLFPGVKIWARRRVGGKTEYYLTAVELEEELVLVDSSLHNKVAAWLVESGVIFQGYRVAKKEPAFGKGRFDLLLESPTGGRALVEVKGVTLEAGRRALFPDAPTARGARHMEELARATAEGYEAYVLFLVFRKRAASFSPNWDMDRKFAESLLRAHNAGVGVRAVKLEMFKWGLRYVGELPVDLTPPF
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: YDIS_BACSU
Sequence: MEISKQTSDLLLSLEKKKGTLPKFSVLRSIPRNRIIYGAPGTGKSNYLEREVGKIFGDNPYVFTRVTFFPGYTYGQFIGAYKPVPIYKKLSGEEEIFSSNFRDKMENFEPMIDYQFVPGPFIDVLIKALKNRYTNFILIIEEINRANAASVFGDIFQLLDRNKNGESDYPVTFGPDIMNYLARNGIKDEMIKLPSNFFIWATMNNADQGVLPLDTAFKRRWSFEYLELEKYRKAVDSWKLSLRYKGHNKVIMWNDFRDIINKRLKGKVPEDKLLGPFFLKESELWNQNVFKNKLLYYLKEDVFKHNPTIDFLNASTFSELIEKYDGSDNIFTFDIDDSSFVSD
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-CTCGAG-3'; the cleavage site is unknown.
What are the official names of this protein?
Type II restriction enzyme BsuMI component YdiS, R.BsuM, R.BsuMI, Endonuclease BsuMI component YdiS, Type-2 restriction enzyme BsuMI component YdiS.
Protein: MUTA_PORGI
Sequence: MAKEKEKLFSEFPPVSREAWIDKITADLKGVPFEKKLVWRTNEGFNVNPFYRREDIEDLKTTTSLPDEYPYVRSTRMHNEWLVRQDIVVGDNVAEANEKALDLLNKGVDSLGFYLKKVHINVDTLAALLKDIELTAVELNFNCCITRAADLLSAFSAYVKKVGADPNKCHGSVSYDPFKKQLVRGVSNPDWVKMTLPVMDAARELPAFRVLNVNAVNLSDAGAFITQELGYALAWGAELLDKLTDAGYKPEEIASRIKFNFGIGSNYFMEIAKFRAARWLWAQIVGSYGDQYKNETAKIHQHATTSMWNKTVFDAHVNLLRTQTETMSAAIAGVDSITVLPFDVTYQQSDDFSERIARNQQLLLKEECHFDKVIDPSAGSYYIETLTNSIGEEAWKLFLSVEDAGGFTQAAETASIQKAVNASNIKRHQSVATRREIFLGTNQFPNFTEVAGDKITLAQGEHDCNCVKSIEPLNFSRGASEFEALRLATEKSGKTPVVFMLTIGNLAMRLARSQFSSNFFGCAGYKLIDNLGFKSVEEGVDAALAAKADIVVLCSSDDEYAEYAPAAFDYLAGRAEFVVAGAPACMADLEAKGIRNYVHVKSNVLETLRAFNDKFGIR
What is the function of this protein?
Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.
What are the official names of this protein?
Methylmalonyl-CoA mutase small subunit, MCM-beta.
What is the protein family that this protein belongs to?
Belongs to the methylmalonyl-CoA mutase family.
Protein: TIG_PARXL
Sequence: MANVVENLGKLERRVTISLPKDAVQKEVDSRIRQLAKNVRMPGFRPGKVPLKMVTQQYSGQVEAEVLSDKVGKEFFDISRAENLRVAGQPSFAPKTDATEGDYAFDATFEVYPEVKLGDVATAEIERTTTTISEAEIDRTLDILRKQRVHFHARGEAGEHGDGGGDTAAKEGDRVTVDFVGKIEGEVFQGGSADDFAFVLGEGRMLPEFEKAATGLKVGESKEFDLAFPEDYHGKEVAGKTAQFTITMKKIEWPHLPEIDAEFAKSLGIEDGDLTKMRAEIKDNLEREAKRRTQAIVKNQVMDALLKISELDVPNALIEQDQERLVAMARQDLEQRGVPNAKDAPIPAAMFKEQAERRVKLGLVLAELVKANELQAKPEQIRAEVDEFAKSYEDPKEVVRWYYSNQQRLAEMEAYVVEANVVEFVLSKAKVTDKEVSFEELASATAQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RL14E_SULIA
Sequence: MPAIEVGRICVKVKGREAGSKCVIVDIIDDNFVLVTGPKDISGVKRRRVNILHLEPTDKKIDIQKGASDEEVRKKIEEAGLTEYMKERIKIKIPTL
What are the official names of this protein?
50S ribosomal protein L14e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.
Protein: Y1034_CHLPM
Sequence: MEMPNLGDMMKQIQQAGAKMQDVQKQLEKTVTHGEAGGGMVKVSVNGRQRLLSLAIDPDIMDDREMVQDLVLAAVNSAIEESGRVSQEEIAKVAGGMINPADILKNMGK
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Cvib_1034.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SP0J_THET2
Sequence: MSRKPSGLGRGLEALLPKTGAGVVRLPLASIRPNPRQPRKRFAEESLKELADSIREKGLLQPLLVRPQGDGYELVAGERRYRAALMAGLQEVPAVVKDLTDREALELALVENLQREDLSPVEEARGYQALLEMGLTQEEVARRVGKARSTVANALRLLQLPPEALEALERGEITAGHARALLMLEPEDRLWGLKEILEKGLSVRQAEALRERLAMAPKRSAEPSPLSLELSRHLGLPVRVVGGKKGKVVIQYRSLEELEALLRRLGYQA
What is the function of this protein?
Probably involved in chromosome partitioning.  Binds to a plasmid centromere-like site parS.  Stimulates the ATPase activity 10-fold of Soj; the first 20 residues may be responsible.
What are the official names of this protein?
Chromosome-partitioning protein Spo0J.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
Protein: MFNA_HALSA
Sequence: MTRGEARRPPQEFDRVLSSMCTTPHPAAREAAQAFLATNPGDPETYPAVAERERDAVALLGEIVGLSSPHGYIAAGGTEANLQAVRAARNRADADAVNVVAPASAHFSFQKAADVLGVELRLAPTDGDHRADVAAVADLVDGDTAVVVGVAGTTEYGRVDPIPALADIAAGVDANLHVDAAWGGFVLPFTDHDWSFADAPVNTMAIDPHKMGQAPVPAGGFLARDPETLDALAIETPYLESDTQPTLGGTRSGAGVAGALASLRALWPDGYREQYERTQGNAEYLAAELAARGYDVVDPELPLVAADMPDAEFQALREEGWRISRTASDALRVVCMPHVTREMLAAFLDDVDALA
What is the function of this protein?
Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.
What are the official names of this protein?
Probable L-aspartate decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. MfnA subfamily.
Protein: RSGA_HAEIG
Sequence: MAKRKLTQNQTRRIQSNNAKTLHRHKKKDIEWSDEMLGESQEGVVVTRYSIHADVENEQGEIYRCNLRRTLSSLVVGDKVVWRKGNEQLQGVSGVIEAIHPRENEISRPDYYDGLKPIAANIDRIIIVSAVLPTLSLNIIDRYLVVCEIAEIKPLIVLNKVDLLAQEQRQEIEDQLKIYQDIGYEILMISAKSGENMEKLTALLAQGTAIFVGQSGVGKSSLINHILPSVNAQVGDVSETSGLGQHTTTSSRLYHLPQGGNLIDSPGIREFGLWHLDAEQITKGYREFQYVLGTCKFRDCKHLSDPGCALREAVEQGKISPVRYDNYHRLIESLSETKSQRHFSLV
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_MYCLE
Sequence: MKVLAAMSGGVDSSVAAARMVDAGHDVVGVHLALSTVSGTLRTGSRGCCSKEDVSDARRVADVLGIPFYVWDFAEKFQEDVIDNFVSAYARGETPNPCVQCNQRIKFSALSVRALMLGFDTVATGHYARLSGGRLRRAVDRGKDQSYVLAVLTAQQLRHAAFPIGDTLKRQVRAEAARRGLLVADKPDSHGICFIPSGNTRAFLSECIGIRRGSVVDADGTVLAEHDGVHGFTVGQRKGLGIVGPGPNGRPRYVTAIDADTATVYVGDAADLGVHTLIGRAPVFTAGAAPLGPVQCVVQIRAHGETAVAVVELIGDELFVRLCEPLRGVARGQTLVLYRLDPDGDEVLGSATIASMSA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX3L1_DANRE
Sequence: MSDGDKNGRDNHEEALVPVEVWQELERAECLARGAALKWASGVFCRPEHLEKLGQYKKRESQRTASIQSRLKSVVQSYLEGVDWGLGQLREARAELRGVSHDLYKANLESRKNSEEVTTLETLREISVSHCQLLAAVSNLPRLYKVRSMVLETERLVESRRLLEAHARLMELERWQDEVLLQLQGPRGSSGTELNSEDEELVRNYFSGVGRLVDALAKELWAVVGSGLSLAHQNPTPFVSAVRIVEREEALDQFFLEERRSTSGHNIPMPAGRPRNWRDRFFKVMEEAVSARFRSVSYLHTRGPGLASHLSALQHCIMGDLSTVRHCLEQCVPAHYHLTRAYLHFCHQFLQTHLGLVSGWELEGGEIFAVLNWVLHIYNSSEMMGEPALLAELEIENLGPLISQEGLEQLQNKYVQKVRKSVSEWMQKALEVELTDWQRDQEPDIDHEGYYHTSLPTIITQMLEENARVALMISEALRDQTIQMGLYEMEKLLSRFRDAVIEFGKEHRKDPTVNKFYLHYLLACINNCIILKTSTESLQQQICSFVSNRYSRIPLGPLAALDRAVRKACRLVMDHLLFELQPHLQELLSSTWLDQGDVTLNMCGVLERHCELYNRVRQPCRQRLKEECQWLTVVEYVRAVMQKRLVCRSSDEQKQLAQRMTQDAQQLRDHLQSMEIDGTIGEVNPTALIAALADIINLKDPGMLLLEISGLLSKYPDISEEHVSVLLDIRGDVPKEVRKSVLDFLDQSAPPLPPGYRPIFTEILVPSSSIPFCLPTAKCT
What is the function of this protein?
As part of the exocyst, may play a role in regulated exocytosis.
What are the official names of this protein?
Exocyst complex component 3-like protein.
What is the protein family that this protein belongs to?
Belongs to the SEC6 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle.
Protein: RS13_JANMA
Sequence: MARIAGVNVPNHQHTVIGLTAIYGIGRPRSQKICDTAGVPTTKKVKDLDDNELEKLRDEIAKFIVEGDLRRELSMNIKRLMDLGCYRGMRHRKGLPCRGQRTRTNARTRKGPRKAAQSLKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.