PharMolix/UniProtQA huggingface dataset:
Protein: MRE11_ORYSJ
Sequence: MGDESNTLRVLVATDCHLGYMEKDEIRRFDSFEAFEEICSLAEQNKVDFVLLGGDLFHENKPSRSTLVKTIEILRRYCLNDQPVKFQVVSDQTINFPNRFGQVNYEDPNFNVGLPVFTIHGNHDDPAGVDNLSAIDILSACNLVNYFGKMDLGGSGVGEIAVYPVLVKKGTTFVALYGLGNIRDERLNRMFQTPHAVQWMRPETQDGMSVSDWFNILVLHQNRIKTNPKSAINEHFLPRFLDFIVWGHEHECLIDPQEVPGMGFHITQPGSSVATSLIDGEAKPKHVLLLEIKGNQYRPTKIPLRSVRPFHYAEVVLKDEVDVDPNDQASVLEHLDKIVRNLIKKSSQPTASRPETKLPLIRIKVDYSGFSTINPQRFGQKYVGKVANPQDILIFSKSAKKRQTTGVGNIDDSEKLRPEELNQQTIEALVAENNLKMEILPVDDLDIALHDFVSKDDKMAFYACLQRNLEETRTKLNSEADKFKIEEEDIIVKVGECMQERVKERSLRSKEDSRFTSSSQNLDTGGRSVTAQSNLNSFSDDEDTREMLLGARTTNAGRKASGFTRPSKDATDVAKTGTSRRGRGRGTASMKQTTLNFSQSRSSAAIRSEEVQSSSDEENETNEANEVVESSEPEESPQQTGRKRAAPRGGRGRGRGATAKRGRKADISSIQSMLMSKDDDDDDEDDRPKKPPPRVTRNYGAVRRR
What is the function of this protein?
Involved in DNA double-strand break repair (DSBR).  Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity.  Also involved in meiotic DSB processing.
What are the official names of this protein?
Double-strand break repair protein MRE11, OsMre11.
What is the protein family that this protein belongs to?
Belongs to the MRE11/RAD32 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARGC_PSEPW
Sequence: MIKVGIVGGTGYTGVELLRLLAQHPQAEVAVITSRSEAGVAVADMYPNLRGHYDGLAFSVPDSKALSACDVVFFATPHGVAHALAGELLAAGTKVIDLSADFRLQDAAEWAKWYGQPHGAPELLKDAVYGLPEVNREKIRLARLIAVPGCYPTATQLGFLPLLEAGLADPSRLIADCKSGVSGAGRGAAVGSLFCEAGESMKAYAVKGHRHLPEISQGLRLAAGTDIGLTFVPHLTPMIRGIHSTLYATVADKSVDLQALFEKRYADEPFVDVMPAGSHPETRSVRGANVCRIAVHRPQGGDLVVVLSVIDNLVKGASGQAVQNLNILFGLDERMGLSHAGLLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB1_RHOPT
Sequence: MQPTPSQHPVGAQPLIARPATGIIDPNTGRPVGADDPFFLNVNRELSDKGFFVAATDDLITWARTGSLMWMTFGLACCAVEMMQLSMPRYDAERFGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPIDIYVPGCPPTAEALLYGVMLLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 1, NADH dehydrogenase I subunit B 1, NDH-1 subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COLI_MOUSE
Sequence: MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACKLDLSLETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGSAAQRRAEEEAVWGDGSPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGERPLGLEQVLESDAEKDDGPYRVEHFRWSNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ
What is the function of this protein?
Endogenous opiate.
What are the official names of this protein?
Pro-opiomelanocortin, POMC, Corticotropin-lipotropin.
What is the protein family that this protein belongs to?
Belongs to the POMC family.
What are the subcellular locations of this protein?
Secreted. Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.
Protein: DHPR_DICDI
Sequence: MSKNILVLGGSGALGAEVVKFFKSKSWNTISIDFRENPNADHSFTIKDSGEEEIKSVIEKINSKSIKVDTFVCAAGGWSGGNASSDEFLKSVKGMIDMNLYSAFASAHIGAKLLNQGGLFVLTGASAALNRTSGMIAYGATKAATHHIIKDLASENGGLPAGSTSLGILPVTLDTPTNRKYMSDANFDDWTPLSEVAEKLFEWSTNSDSRPTNGSLVKFETKSKVTTWTNL
What is the function of this protein?
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
What are the official names of this protein?
Dihydropteridine reductase, Quinoid dihydropteridine reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RL9_EXISA
Sequence: MKVILKVDVKGQGKAGEVKNVADAYAKNVLFKKNLAVEATPGNLKAFAAKERRAEEAAEEELNEAKRLKEKLEKETIAVTTKAGEGGRVFGSVTSKQIADALKSMGYKIDKRKIELEHPIKALGFTKVPVKLHHDVVATLNVHVQEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: Y2042_ORYSJ
Sequence: MSAMLNENVPVEFQEAHGYAAREKVVLRMRGRSWTVRLKHTKGRRPRRERAVLRYGWHRFCADNGLAVGDTCFFRALRSAGSGAGDVDDGDGDHVLSVTVHKADGGDPLE
What are the official names of this protein?
B3 domain-containing protein LOC_Os02g10420.
What are the subcellular locations of this protein?
Nucleus.
Protein: UVRC_HELPG
Sequence: MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSICNNEITPNHRASLRIQMMVKQIAFLETILVENEQDALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKKNCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKIAPFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLNACSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEVRSLFNLECVPYRVEIFDTSHHANSQCVGGMVVYENNEFQKDSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGSFVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGIGEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPR_SHIBS
Sequence: MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APR1_ARATH
Sequence: MAMSVNVSSSSSSGIINSRFGVSLEPKVSQIGSLRLLDRVHVAPVSLNLSGKRSSSVKPLNAEPKTKDSMIPLAATMVAEIAEEVEVVEIEDFEELAKKLENASPLEIMDKALEKYGNDIAIAFSGAEDVALIEYAHLTGRPFRVFSLDTGRLNPETYRFFDAVEKHYGIRIEYMFPDSVEVQGLVRSKGLFSFYEDGHQECCRVRKVRPLRRALKGLKAWITGQRKDQSPGTRSEIPVVQVDPVFEGLDGGVGSLVKWNPVANVEGNDVWNFLRTMDVPVNTLHAAGYISIGCEPCTKAVLPGQHEREGRWWWEDAKAKECGLHKGNVKENSDDAKVNGESKSAVADIFKSENLVTLSRQGIENLMKLENRKEPWIVVLYAPWCPFCQAMEASYDELADKLAGSGIKVAKFRADGDQKEFAKQELQLGSFPTILVFPKNSSRPIKYPSEKRDVESLTSFLNLVR
What is the function of this protein?
Reduces sulfate for Cys biosynthesis.  Substrate preference is adenosine-5'-phosphosulfate (APS) >> 3'-phosphoadenosine-5'-phosphosulfate (PAPS).  Uses glutathione or DTT as source of protons.
What are the official names of this protein?
5'-adenylylsulfate reductase 1, chloroplastic, 3'-phosphoadenosine-5'-phosphosulfate reductase homolog 19, PAPS reductase homolog 19, Prh-19, Adenosine 5'-phosphosulfate 5'-adenylylsulfate sulfotransferase 1, APS sulfotransferase 1, Thioredoxin-independent APS reductase 1.
What is the protein family that this protein belongs to?
Belongs to the APS reductase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLO2_HYPNA
Sequence: MSVLIEIHQFPCLNDNYGYLVHEPGSGRTIAIDTPDAAVYLAEAEKMSWTISEIWNTHWHPDHAGGNLKIKEATGCKIIGPAGEADKIPGIDRRVKGGDTVELGGATATVIDVPGHTLGHIAFHFPDQEAAFVGDAVFALGCGRVFEGTMEMMWESLKRIKKLPKKTQLYCAHEYTASNAKFAVTIEPENKALKEYVAWIEKRRAEDKPTVPALLERELETNPFLRADLPEMQLAMGHAGNAAATFGEIRGRKDRF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: FOXN4_XENLA
Sequence: MIDSDISAIMSGIIRTSEQNHHPQSQEYRHMNPSQMGAEELPNDLQSLSWLTSVDVPRLQQMTNTRMDYSHTSQNPLMQQSGHLSNNVHSPGSMIHVPTSMQQGILGLSTLTSHGSNMSQYSMAGHVSPSLQAQQPVYQTHSQQIYGLSQGSQCSSANLYNSSYRAQAQFTQPHLAAHPTQELQPKSYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKDHFLYFKTAPDGWKNSVRHNLSLNKCFEKVENRLSGSSRKGCLWALNPAKIDKMEEEMQKWKRKDLPAIRRSMANPDELDKLIMDRPENCKAPSKLVESEVQAMTTIGNLPGRIPQHQPHRVMTLSLQSIPLHHQIQTQARIASGSPAPAQSPPIHSVPDMTHSPLQQHIMSRAASDFLSLTSDMNTEVDALDPSIMDFALQGNIWEAMKDESFSLDTLGAFSSSPLQLSDCDLGTIGLTPVSSSGDHSFSDFQVTSLYTTYPTLENVAPSQCVPGSGTKPIALL
What is the function of this protein?
Transcription factor that may play a role in neural and some non-neural tissues development, such as retina and lung respectively.  Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3' (By similarity).
What are the official names of this protein?
Forkhead box protein N4.
What are the subcellular locations of this protein?
Nucleus.
Protein: CF130_YEAST
Sequence: MTKKKAATNYAERQNLASEDSSGDSVHFKDFIPLQELLKDKNYVPSVENLEKILYNETMFNDQKICSNLLLEALIITLFTTISGKSALRLIQTSSLKERKSWAQSFENNSSSYASIVLSWKDNDILLLKFLRFLLANKTAPLQINRYNLPEYKLPLSFLIVSKITIPSILLNETYNLLKDYLYSITGRIESLISCSSTFDKPALVVRKILKDYNRMIECRNFYFWYSFNAENRVNLTFSDNISLLMENDEGNAGSGLDDSRFDHQKQPREAIMGRTINDQEQIYSFELNQDGTLEIPNVMEHSLLRHELLFKILNLTTVLTPLLELQFSTLCGLVDPLMQPTPNDKHIISIDFLFQLFLGLMSQSIKTSQEHNDHYDWKFYMCFNMQKIIDATMLRLNCFDFDILNSVNNTDNAVHWKTQLHRWLPHGLNTQDLELLYMIDILAVYTIYKLYEKIPIQLNPFLFSLISLWKNLSCVILLALEIDRIEEENGTYETPLMVRATIRGAAALRSVIATVLNGLVKNNDHDFKHESLNTFMSPYGRKLCHGALYADLRSHTASLLALGASIEDVTDLFADLQSGDRFDEDIRYMFDYECEDYDESFSESDHGGLDESVVNPTEKIASGSNNVFFRRRCNCIFNDDKLVAEDGANEAFGSTNSENVEGAMHNNRNAVHNATTATSDHVVTSPNPLSVRSRSTFEFDYSGEDWRDVPRDFNMYYSPSYSFIHEPKLDVIFSLTLRGATEKLNKEESILLVRSVASCVRNEQDQMILADLESNFSASINGDVEGEGNTKMSKIDNEDLRRTTPDDIYEIWSEESAFERMLNVNHDVAWRLMDEMLMCTGYRRILIWFLTHLELKHSLIYYVFELIMGLRGKPFSGEASDQDKKDDMIYEILKKKQKNEDASGLPFSRQGPIVLSDIETKMLLQEFFMNAAIFLSSKNNEEENEDGEKISLYSLGLVRLICYMVQTLIANDKFFFTKSECTFELQTLLMTWIGILPEAKDLFFKIKTRLAMEEEDSADTMQHEGRKNSDIEKKLNAKPASELNLKLLNLFPSKPANKDDSSPINTLRSFIADYSFDTQVNPPGRRVVFYDGKILPLPKADKPIPLHEYITLAELDVGDSE
What is the function of this protein?
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
What are the official names of this protein?
Protein CAF130, 130 kDa CCR4-associated factor.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PURA_MESFL
Sequence: MREINSLVVVGSQWGDEGKGKMTDYFAQKADVVVRFAGGDNAGHVINFNGQKHKVTIIPSGIFNSEVTSVIGNGCAVNLINLVKELETIKNSGVKLGKLLISDRAQLILPYHILIDGAQEESRGARKIGTTKRGIGPTYQDKAARLGIRVADIEEEDFKETFKEIFEYQMMFLDRMFNVESIDFEETYANLINAYNVIKDCVTDTGIFVEQAIKNGKKVLFEGAQGALLDIDHGTYPYVTSSNTSANNASTGTGISHKLINNTLGVVKAYSTRVGAGAFPTELLNEVGDGIRERGHEYGSNTKRPRRVGWLDLVALKHAIRTSGIDYLFITLLDVLSGVEELLICDKYILNGEEINYIPATSSKHEKCKANYISMPGWKEDITKVKHFEELPLNAKNYLNKIAEICEVEISGFSVGPDRLQTVITKEIM
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRG1_YEAS1
Sequence: MAQNFGKIPSHKSYVLSLYRTVLRNIPKCCHSYAFQYEIKKTLSKQLFKHKHDKSSWSVYTLLNEFSLLNNCLLEGKLQEIKNLMKPLKKMKKQLETTKILNSLTSLGDVKTNDPEEVRRFHVLSAYIKRKQDLGLLPAYIPKTYQHKLLLPLALNEHACLKLFHIQQKLKNGPPSAGLSYTKEGRNQIWFVRSPINKGRQQSKKLGILIRKERKDSQKNIDNLNFCEINAAWALHEAIWEEYLESKKIIKVNLPKYLEYAANIPKSTKCNPSSQYQKIKEWVDPVREIMFELHSKSFQRVEYFNKYKEKLLKNGGQLAYFDKKSKEMYAKRLTLFRKMSKETLPYVTLFIEGRDLPSVLAKYGF
What is the function of this protein?
Essential for respiratory growth and required for mitochondrial protein synthesis.  Required for vacuolar acidification (By similarity).
What are the official names of this protein?
Required for respiratory growth protein 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HSLV_THEMA
Sequence: MKFHGTTILVVRRNGQTVMGGDGQVTFGSTVLKGNARKVRKLGEGKVLAGFAGSVADAMTLFDRFEAKLREWGGNLTKAAVELAKDWRTDRVLRRLEALLLVADKENIFIISGNGEVIQPDDDAAAIGSGGPYALAAAKALLRNTDLSAREIVEKAMTIAGEICIYTNQNIVIEEV
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_BURMA
Sequence: MSDVENQPFFNIQRIYLKDLSLEQPNSPAIFLEQEMPAVEVEVDVKAERLAENVYEIVVAGTVTAKVREKVAFLVEAKQAGIFDIRNIPAEQIDPLCGIACPTILFPYLRSNIADSITRAGFPPIHLAEINFQALYEQRLAEISQQQQQGGAPNGTTLN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZER1_MOUSE
Sequence: MASDTPESLMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDQLVNEYVELVSAACTFEPHETFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRKQDLVELYLTNCEKLSAKSLQTLRSFRHSLVSLSLSGCANIFYEEDNPGGCEDECLVNPTCQVLVKDFTFEGFSRLRFLNLGRMIDGIPVESLLRPLNSLAALDLSGIQTSDATFLTQWKDSLMSLVLYNMDLSDDHIRVIVQLHKLRSKILTCGPHLISSHLDISRDRLSSYYKFKLTRKVLSLLVQKLGNLMSLDISGHMILENCSISKTDEEAGQTSTEPSKSSIMPFRALKRPLQFLGLFETSLCRLTHIPAYKVSGDKNEEQVLNAIEAYTEHRPEITSRAINLLFDIARIERCNQLLRALKLVITALKCHKYDKNIQVTGSAALFYLTNSEYRSEQSVKLRRQVIQVVLNGMESYQEVTVQRNCCLTLCNFSIPEELEFQYRRVNELLLGILSPTRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFLNFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESKADGIEVSYNACGVLSHIMFDGPEAWGVCEPQRAEVEDRMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPLLIKEGGMPLLRDLIKMATARQETKEMARKVIEHCSNFREENMDTSR
What is the function of this protein?
Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.  Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation.  Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites.  Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation.
What are the official names of this protein?
Protein zer-1 homolog, Zyg-11 homolog B-like protein.
What is the protein family that this protein belongs to?
Belongs to the zyg-11 family.
Protein: PRGR_PANTR
Sequence: MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSNEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQGVLSPLMSRSGCKAGDSSGTAAAHKVLPRGLSPSRQLLLPASGSPHWSGAPVKPSPQPAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPXRSPLATTMMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAXSAFAPPRSSPSASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRAPPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGIPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
What is the function of this protein?
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Transcriptional activator of several progesteron-dependent promoters in a variety of cell types.  Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
What are the official names of this protein?
Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity).
Protein: TPA_PULPI
Sequence: FFGSVLKLIPKIL
What is the function of this protein?
Has antibacterial activity against the Gram-positive bacterium S. aureus ATCC 25923 and the Gram-negative bacterium E. coli ATCC 25726.
What are the official names of this protein?
Temporin-PTa.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MEGL_TREDE
Sequence: MNRKELEKLGFASKQIHAGSIKNKYGALATPIYQTSTFAFDSAEQGGRRFALEEEGYIYTRLGNPTTTVVEEKLACLENGEACMSASSGIGAVTSCIWSIVNAGDHIVAGKTLYGCTFAFLNHGLSRFGVDVTFVDTRDPENVKKALKPNTKIVYLETPANPNMYLCDIAAVSKIAHAHNPECKVIVDNTYMTPYLQRPLDLGADVVLHSATKYLNGHGDVIAGFVVGKKEFIDQVRFVGVKDMTGSTLGPFEAYLIGRGMKTLDIRMEKHCANAQKVAEFLEKHPAVESIAFPGLKSFPQYELAKKQMKLCGAMIAFTVKGGLEAGKTLINSVKFATIAVSLGDAETLIQHPASMTHSPYTPEERAASDIAEGLVRLSVGLEDAEDIIADLKQALDKLVK
What is the function of this protein?
Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia; methanethiol (methyl mercaptan) is considered to be one of the main causes of the oral malodor associated with periodontitis and may also play a role in the pathogenicity of T. denticola.  Also displays homocysteine desulfhydrase activity, degrading homocysteine to produce hydrogen sulfide, 2-oxobutanoate and ammonia.
What are the official names of this protein?
L-methionine gamma-lyase, MGL, Homocysteine desulfhydrase, L-methionine-alpha-deamino-gamma-mercaptomethane-lyase, METase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family. L-methionine gamma-lyase subfamily.
Protein: LAT4_HUMAN
Sequence: MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTEPENVTNGTVGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVDLEVKCQPDAAVAPSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQKTVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV
What is the function of this protein?
Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:30379325, PubMed:15659399).  The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:15659399).
What are the official names of this protein?
Large neutral amino acids transporter small subunit 4, L-type amino acid transporter 4, Solute carrier family 43 member 2.
What is the protein family that this protein belongs to?
Belongs to the SLC43A transporter (TC 2.A.1.44) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL2_SPIKU
Sequence: MPIKSFKPVTPSRRNMTSLDYSVLTTDRPEKSLIKTRKKHAGRNNQGVITTRHKGGGHKVKYRIIDFKRNKDNIIGKIATIEYDPNRNAFICLVNYVDGEKRYILAPKTIKVGMQIVSAEKTDIKVGNCMKLKNIPEGTVLHNLELRPGKGGQLARSAGSSVQFLGKDEDGKYVTIRLTSGEVRKVLGECRATVGEVGNEDYALVNWGKAGRNRWRGIRPTVRGSAMNPNDHPHGGGEGKAPVGRKAPMTPWGKKALGVKTRNKKKASTKLIVRRRTK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SYP_MESM1
Sequence: MNIKLLDKITPLEQDFAKWYTDVITKGNLATYGVLKGNIVFMPNSYGIWENVQSNFNKIIKELNVKNLYLPTLIPESLINSEKDHVQGFAPELITVEKVGDKVLNEKLFLRPTSEVLFAEYFKTQLNSYNDLPLLLNQWANVFRWEKTTSPFLRNSEFLWQEGHTSHYSEEEAHQFSKKMIQIYANFFEEFLAIPVIIGQKTESEKFAGAHTTYTIEAMMKDGRALQSGTSHYLGQNFAKAFDISFKDKDNSKSFVYQTSWGISTRLIGAIIMVHGDNRGIIMPPKIATNQVDIITVFANKNPEVLQKANDLFKTLKNDFRVRINDSNKSVGFKAAQSEIEGTPIRIEIGPEDLKQNKVILIRRDTQEKIDVKIDELKSEIFSQIEKIHENLLMQAKRLLNEKIVDVEDYESLKKEIAKGNFVRVPFDGDKKEEEIIKKETFATPRCIPLNFIGETKKCIMTNKETKRYVIFAKSY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
Protein: IF1_RICCK
Sequence: MSKDDLIQFTGTVLELLPNANFRVKLENDHLIIAHTSGRMRKNRIRILLGDKVTVEMTPYDLTKGRVIHRH
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.