PharMolix/UniProtQA huggingface dataset:
Protein: RALA_RAT
Sequence: MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRADQWNVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL
What is the function of this protein?
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking.  Accomplishes its multiple functions by interacting with distinct downstream effectors.  Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles.  Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor.  Required for anchorage-independent proliferation of transformed cells (By similarity).  The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (By similarity).  During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells.  Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (By similarity).  During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity).
What are the official names of this protein?
Ras-related protein Ral-A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody, Midbody ring. Mitochondrion. Note=Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles. May colocalize with CNTRL/centriolin at the midbody ring. However, localization at the midbody at late cytokinesis was not confirmed. Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission.
Protein: MNME_SHEON
Sequence: MTTDTIVAQATAPGRGGVGIIRISGDKATNVAMAVLGHLPKPRYADYCYFKSASGQVIDQGIALFFKGPNSFTGEDVLELQGHGGQIVLDMLIKRVLEVEGIRIAKPGEFSEQAFMNDKLDLTQAEAIADLIDATSEQAAKSALQSLQGEFSKEVHELVDQVTHLRLYVEAAIDFPDEEVDFLSDGKIANALYKIIDKLIAVQASAKQGSIIREGMKVVIAGRPNAGKSSLLNALAGKESAIVTEIAGTTRDVLREHIHLDGMPLHIIDTAGLRDTTDTVEQIGIERAWNEINSADRVLFMVDGTTTTAVDPHDIWPDFINRLPTNLGVTVIRNKADLTGENLEMTEEKGYSVYRISAKTGLGVDELKQHLKSLMGYQSNLEGGFIARRRHLEALEIAASHLQLGKEQLEVYLAGELLAEELRMAQLALSEITGRFTSDDLLGKIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP73_BPT7
Sequence: MGKKVKKAVKKVTKSVKKVVKEGARPVKQVAGGLAGLAGGTGEAQMVEVPQAAAQIVDVPEKEVSTEDEAQTESGRKKARAGGKKSLSVARSSGGGINI
What is the function of this protein?
Plays an essential role most probably in virion tail assembly.  May form a scaffold around which gp11 and gp12 polymerize.  Gets ejected from the infecting particle into the bacterial cell.
What are the official names of this protein?
Protein 7.3, Gene product 7.3, Gp7.3.
What is the protein family that this protein belongs to?
Belongs to the T7likevirus protein 7.3 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the tail.
Protein: TRPC_NITWN
Sequence: MADILTRIETYKREEIASAKRARPLGEVTAAAKAAPPPRGFTDTIRAKLARGDYALIAEIKKASPSKGLIRADFDPPSLARAYEAGGAACLSVLTDAPSFQGHLDFMVAARAATSLPVLRKDFIFDTYQVVEARAHGADCILIIMAALDDDAAKDIEATALDLGMDVLLEIHNREELDRALKLRSPMIGVNNRNLRTFETTLETSEGLAPYIPKERLMVGESGIFTPADLARLERVGISTFLVGESLMRQADVTAATRTLLKHA
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: ISPG_ECOL5
Sequence: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNNDMIDQLEARIRAKASQLDEARRIDVQQVEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: DB3S_DIOPO
Sequence: MSSSTLLHLLLLSSLLFSCLANVEDEFSYIEGNPNGPENWGNLKPEWETCGKGMEQSPIQLRDNRVIFDQTLGRLRRNYRAVDARLRNSGHDVLVEFKGNAGSLSINRVAYQLKRIHFHSPSEHEMNGERFDLEAQLVHESQDQKRAVVSILFIFGRADPFLSDLEDFIKQFSSSQKNEINAGVVDPNQLQIDDSAYYRYMGSFTAPPCTEGISWTVMRKVATVSPRQVLLLKQAVNENAINNARPLQPTNFRSVFYFEQLKSKVCAI
What is the function of this protein?
Storage protein of tuber.  Involved in protection against oxidative stress (Probable).  Has carbonate dehydratase and weak trypsin inhibitor activity detected by measuring the dehydration of sodium bicarbonate and the inhibition of trypsin-catalyzed hydrolysis of N-benzoyl-L-arginine-4-nitro anilide, respectively (PubMed:10552514).  Contrarily, no carbonate dehydratase or trypsin inhibitor activity detected by measuring the hydrolysis of 4-nitrophenyl acetate or the inhibition of bovine trypsin-catalyzed hydrolysis of N-benzoyl-L-arginine ethyl ester, respectively (PubMed:15047697).  Has dehydroascorbate (DHA) reductase and monodehydroascorbate (MDA) reductase activities (Ref. 5).  Catalyzes the reactions of carbonate dehydratase and DHA reductase independently of zinc and glutathione (GSH).  The coupled reaction is capable of recycling a plant antioxidant ascorbate using ubiquitous compounds H(2)O and CO(2) (By similarity).  Exhibits antioxidant activity.  Able to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and hydroxyl radicals (PubMed:11600050).  Exhibits immunomodulatory activity.  Activates Toll-like receptor 4 signaling pathways by up-regulating the gene expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1 beta and interleukin-6, and chemokines RANTES and MCP-1, in mouse RAW 264. 7 macrophages.  Stimulates the phagocytosis of E. coli by the LPS-treated mouse macrophages (By similarity).
What are the official names of this protein?
Dioscorin DB3S, Tuber storage protein DB3S.
What is the protein family that this protein belongs to?
Belongs to the alpha-class carbonic anhydrase family.
Protein: RAD16_YEAST
Sequence: MQEGGFIRRRRTRSTKKSVNYNELSDDDTAVKNSKTLQLKGNSENVNDSQDEEYRDDATLVKSPDDDDKDFIIDLTGSDKERTATDENTHAIKNDNDEIIEIKEERDVSDDDEPLTKKRKTTARKKKKKTSTKKKSPKVTPYERNTLRLYEHHPELRNVFTDLKNAPPYVPQRSKQPDGMTIKLLPFQLEGLHWLISQEESIYAGGVLADEMGMGKTIQTIALLMNDLTKSPSLVVAPTVALMQWKNEIEQHTKGQLKIYIYHGASRTTDIKDLQGYDVVLTTYAVLESVFRKQNYGFRRKNGLFKQPSVLHNIDFYRVILDEAHNIKDRQSNTARAVNNLKTQKRWCLSGTPLQNRIGEMYSLIRFLNINPFTKYFCTKCDCASKDWKFTDRMHCDHCSHVIMQHTNFFNHFMLKNIQKFGVEGPGLESFNNIQTLLKNIMLRRTKVERADDLGLPPRIVTVRRDFFNEEEKDLYRSLYTDSKRKYNSFVEEGVVLNNYANIFTLITRMRQLADHPDLVLKRLNNFPGDDIGVVICQLCNDEAEEPIESKCHHKFCRLCIKEYVESFMENNNKLTCPVCHIGLSIDLSQPALEVDLDSFKKQSIVSRLNMSGKWQSSTKIEALVEELYKLRSNKRTIKSIVFSQFTSMLDLVEWRLKRAGFQTVKLQGSMSPTQRDETIKYFMNNIQCEVFLVSLKAGGVALNLCEASQVFILDPWWNPSVEWQSGDRVHRIGQYRPVKITRFCIEDSIEARIIELQEKKANMIHATINQDEAAISRLTPADLQFLFNN
What is the function of this protein?
Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA.  Involved in differential repair of DNA after UV damage.  Will repair preferentially the MAT-alpha locus compared with the HML-alpha locus.
What are the official names of this protein?
DNA repair protein RAD16, ATP-dependent helicase RAD16.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDRP_PELPD
Sequence: MKRIYVISDATGETAERVIRAALSQFYYDEVRVVRLCQIHNENDVQQAMSVAIAEPGMIAYTLVDPSLSQKVAQLAEDHGMYAVDLLGGLIYSLSCFLGATSQAKPGLLHRIDTDYFKRMEAVNFTVTHDDGQDTQYLHKADLVLVGASRSSKTPLSMYLAHKGYKVANVPLIIGIDPPVELFQIEQEKVVGLVIDPKRLVEIRTSRLINMRQSPRGNYADYQRVEDEITSCRRLYRQHPQWMVIDMTNKSVEEAASEILRKMAVREKRITEARVKGDIS
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: LEPA_PROMS
Sequence: MTDISVSKIRNFCIIAHIDHGKSTLADRLLQDTGTVQQRDMQEQFLDSMDLERERGITIKLQAARMKYKADDSQEYVLNLIDTPGHVDFSYEVSRSLQACEGALLVVDASQGVEAQTLANVYLALENNLEIIPVLNKVDLPGADAEKIKQEIEEIIGLDTSNAINCSAKTGVGIKDILEAIVRRVPPPQDEIKLPTKALIFDSYYDPYRGVIVYFRVISGSLNKREKILLMASKKNYELDEIGIMAPDQQQVDELHAGEVGYLAASIKSVADARVGDTITLLNSPANDPLPGYKTANPMVFCGLFPTDADQFPDLRVSLEKLQLSDAALKYEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYDLDLIVTAPSVIYKVNLNQQEHIFIDNPSTIPDPQLRESIEEPYVKMEIYAPNEFNGTLMGLCQERRGVFIDMKYITTDRVTLIYEIPLAEVVTDFFDQMKSRTQGYASMEYHLIGYRKNDLVRLDVLINSERADPLTSIVHKDKAYGIGRSLVEKLKELIPKQQFKIPIQASIGSRIIASESISALRKDVLSKCYGGDISRKKKLLKKQAKGKKRMKAMGKVEVPQEAFMAVLKLNQ
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MED23_DROME
Sequence: METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLLRAAGASGYHIKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVDYKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPYHWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVNLIVQAMEMTEANDATAGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQLMWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKARVENMNITRPLPIALKNHYDFLQHLVTANTMMNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLDALNGTSKSPNGGQIPAVTFSVTVLDSLTVHSKMSLIHSFVTQMLKQAQSKGQVPAAALLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLLHSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELNRVLILTLARSMHVHGGGDEMQGWCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQLKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDYLVAEVASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFLIIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIPLPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYERILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPYKVYLQSQDSLWTPELSYYMSLIRRLADTISGKNVFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWTYRFNAFELFNFKTVREAMLEKTYAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGIAVLLYEILEIVDKHHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLRFITHLNLEDIHTEKINDNTSNNAITSQTQSPMQTQHQQQPQQPHQQQQQQQQQQQQQQQQQQQQQQMQQQQINAVQTTSVPLGSGGNLQQQQQINQQQQMYMQHMQQHQHMQNMRHN
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).  Required for transcriptional activation in response to heat shock.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 23, Mediator complex subunit 23, dSUR2, dTRAP150.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 23 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TBP2_HALVD
Sequence: MSGPADSIEIQNVVASTGIGQELDLEALADDLPGADFNPDNFPGLVYRTQDPKAAALIFRSGKIVCTGAKSIDDVHDALGIIFDKLRELKIPVDDEPEITVQNIVSSADLGHNLNLNALAIGLGLEDVEYEPEQFPGLVYRMDEPKVVILLFGSGKIVITGGKRTDDAETAVEEIVERIDALGLLG
What is the function of this protein?
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
What are the official names of this protein?
TATA-box-binding protein 2, Box A-binding protein 2, BAP 2, TATA sequence-binding protein 2, TBP 2, TATA-box factor 2.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
Protein: EFG_ESCF3
Sequence: MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGANPVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELANEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDEAPSNVAQAVIEARGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN114_PANTR
Sequence: MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESTETSCHGCRKKFFLSKIRSHVATCSKYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
What is the function of this protein?
E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates.  In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity.  Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3.  May promote the ubiquitination of TRAF6 as well.  Acts also as a negative regulator of T-cell activation.  Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation.  Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C.  This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence.  May play a role in spermatogenesis.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF114, RING finger protein 114, RING-type E3 ubiquitin transferase RNF114, Zinc finger protein 313.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CK040_HUMAN
Sequence: MALVQALVPREREPKLSILQMDRGDPQHSSHWCPEREKVKLLTLKPRETSKNILINFYRAFNLDKDVFIHQANHPLTVPSSVVMGDNGHTLAEDDKRPCFRVLPCYLERVSSGISISWISAPLPVGAMKHQLLCDLMDLITLSFWLAGQCMSLKATNMQHCKCSIATSDWAIELDRTDYKTLPSEYSILALLQVFAGKNCMDRVLLHVDVNYLKSLP
What are the official names of this protein?
Putative uncharacterized protein C11orf40, Ro/SSA1-related protein.
Protein: NEK3_DICDI
Sequence: MDKYEEIKTIGKGSFGRAILVKRKSDGLLLVLKEINVMEMQPKERSDAMNEVNLLSMLDHENIIGYYDSFILNGCLYIIMEYANAGDINLEIKKRTLQNKTFSEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGDYFIKLGDFGIAKILNSETSLASTVLGTPYYLSPELIQNEKGYDHKSDIWSLGCVLYELTTLKHAFNAANLPALVLKILKGTYPPIPSHYSNDLRNLISSMLQIDPKNRPSVNDILELPFINQYLGIPLKPFDSNLNENNNDSLNISNNSSGSNNSASNNISSSTEVKDQKFQNIPLAMARNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKSNVDDVNSSSTTTTSSSIVKSKVNTTVSPPLSPKKPITTTTTKTTSLKTTPSIKPTLVKTPTIKSSLVKTPLSKTPISGTKNPTTSKITPSIKTPLPKAPISSKTPTRLVSKPTTPKITTPKSTSTMITPKRTTTTTTTPTPTTATTTPKKSSLSSSSSSSVKPPPPTTTTTTPSKDRSSVNTINKPMASNLSSQISSSSSSSSSSNSQFRPTTPSKERMSPTSTSTKSPTNPSPTLSSSSSLPKSSLKSDSLCTSPPRFSNTTGSSGGIGVSGNGNSNVNSTVLNRSVSSLSIQHKPTNSGSSSISSSSSGNNSNSNTTTNNNTTSTTPIRPGLKSTKSMLELSTPTSISTSNKSTTTTPTSSRSNTPSTGRLSLTTSIPRPPSSNGSNTGSSSSTTTTPTKISTTSSSSSLNKLTTPIKSSTTTSTTASTNSQTIKKSITPIKVTSQQVDSTISNIKNNIVIGNSVSTKTNISVISHLSPSIKPLPTQSIITQLPTSASTASTASTTNTTLTSGTNTMTTKKRTDFKLDDLGHRSKLNSVKLSSKSSSPIKTSSSSSSSSSSSSSITDKKSINRVKLNNLKEKNKEIINNIKISSTIPKPSNINSSSSSAFSDLNSSGSSSLNNSLTSSSSSIITNQNNQNNQNNQNNQNNQNNLKIINELILQNNLNNSISKENLDDKRLHSRANALRHFCSSIFGEDKFKETYNLLKSQSPSTSNNEIVDIASIENQLSQLIGDKIYYLKYLQQLIYCESQI
What are the official names of this protein?
Probable serine/threonine-protein kinase nek3, Never in mitosis protein A-related protein kinase 3, NimA-related protein kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Protein: CHED_SOLUE
Sequence: MEQIIVGVADCRVGHAPEQVLATYALGSCIGLSIYDPKAAIGGMLHYMLPDSTIDPARGRENPYMFADTGIPKLVEQVCGRGANRRRLIAHAAGGASMMDPQAVFDIGKRNYLALRKILWKAGILLAGEAVGGTNSRTVRLEIGSGRLWLQENGKQKELVPSFPQKGGN
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: PURQ_BACVZ
Sequence: MKFAVIVLPGSNCDIDMFHAVKDELGEEVEYVWHEETSLDGFDGVLIPGGFSYGDYLRCGAIARFANIMPAVKKAAAEGKPVLGVCNGFQILQELGLLPGAMRRNKDLKFICRPVELIVQNGGTLFTSSYEKGQSITIPVAHGEGNFYCDDETLERLKENNQIAFTYGGDINGSVSGIAGVVNEKGNVLGMMPHPERAVDELLGSADGLTLFRSIVKNWRETHVATA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCFL_ECOLI
Sequence: MRKGCFGLVSLVLLLLVGCRSHPEIPVNDEQSLVMESSLLAAGISAEKPFLSTSDIQPSASSTLYNERQEPVTVHYRFYWYDARGLEMHPLERPRSVTIPAHSAVTLYGSANFLGAHKVRLYLYL
What are the official names of this protein?
Uncharacterized protein YcfL.
Protein: CBR3_HUMAN
Sequence: MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841).  Has low NADPH-dependent oxidoreductase activity.  Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:18493841, PubMed:15537833, PubMed:19841672).  Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672).  Exerts activity toward ortho-quinones but not paraquinones.  No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672).
What are the official names of this protein?
Carbonyl reductase [NADPH] 3, NADPH-dependent carbonyl reductase 3, Quinone reductase CBR3, Short chain dehydrogenase/reductase family 21C member 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_ECO27
Sequence: MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARAAVRGGKGGKRKGSSLQQGFQKPAQAVNRDVVIGETITVGELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAGVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFVHVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITETDATLAAASNAILVGFNVRADASARKVIEAESLDLRYYSVIYNLIDEVKAAMSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVVKRHNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIQRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.