PharMolix/UniProtQA huggingface dataset:
Protein: AHR_MUSMC
Sequence: MSSGANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRNGGQDQCRAQIRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPDSAQGVDEAHGPPQAAVYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCTRGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSNARLIYRNGRPDYIIVTQRPLTDEEGREHLQKRSTSLPFMFATGEAVLYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPSSLMSALIQQDESIYLCPPSSPAPLDSHFLMGSVSKCGSWQDSFAAAGSEAALKHEQIGHAQDVNLALSGGPSELFPDNKNNDLYNIMRNLGIDFEDIRSMQNEEFFRTDSTAAGEVDFKDIDITDEILTYMQDSLNNSTLMNSACQQQPVTQHLSCMLQERLQLEQQQQLQQPPPQALEPQQQLCQMVCPQQDLGPKHTQINGTFASWNPTPPVSFNCPQQELKHYQLFSSLQGTAQEFPYKPEVDSVPYTQNFAPCNQPLLPEHSKSVQLDFPGRDFEPSLHPTTSNLDFVSCLQVPENQSHGINSQSAMVSPQAYYAGAMSMYQCQPGPQRTPVDQTQYSSEIPGSQAFLSKVQSRGIFNETYSSDLSSIGHAAQTTGHLHHLAEARPLPDITPGGFL
What is the function of this protein?
Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer.  Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE).  Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation.  Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene).  Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons.  Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists.  Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands.  Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity.  Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1.  Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1.  The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription.
What are the official names of this protein?
Aryl hydrocarbon receptor, Ah receptor, AhR.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
Protein: SUFS_PHOLL
Sequence: MTFSVKKVRQDFPVLTQQVNGHPLVYLDSAASAQKPVSVIERESEFCLHQYAAVHRGIHTLSSAATRMVENVRYQIAQFIHAQSHEEIVFVKGTTEGINLIANSYGRKFINNGDNIVITEMEHHANIVPWYMLAEQIGFEIRVWPLNENGELDQAILASLIDSRTKLLSFTHLSNVLGTVNPVRQIIKQARKLADEQEGRLHILVDGAQAIMHKQIDVQDLDCDFYVFSSHKLYGPTGIGVLYGRKSLLDAMPPWEGGGAMIKQVSLQKGITYAEPPWRFEAGTPNITGIIGLGAAVDYVTSLGLDEIQQHEQALMDYAMARLKEVKTLKLYGPEQRQGVIAFNLGRHHAYDVGSFLDQYGIAIRTGHHCALPVMEHYHVSSMCRASLAIYTTQEDIDALVVALQRIEQLLG
What is the function of this protein?
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation.  Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine.  Selenocysteine lyase activity is however unsure in vivo.
What are the official names of this protein?
Cysteine desulfurase, Selenocysteine beta-lyase, SCL, Selenocysteine lyase, Selenocysteine reductase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIRO2_ARATH
Sequence: MMLGGKSSAGGRTSLRVAVAGDKGTGKSSLISAVASETFPDNVPRVLPPITLPADAFPDYIPITIVDTPSSIDNRIKLIEEFRKADVVLLTYACDQPSTLDRLSSYWLPELRRLEIKAPVIVVGCKLDLRDERSPARLEDIMSPIMKEYREIETCIECSALTLIQVPDVFYFASKAVLHPTFPLFDQEKQCLKPRLRRAVQRIFNLCDHDLDGALNDAELNDFQVNCFGAPLDPVELMGVKKVVQERQPDGVTDLGLTLPGFLFLFSLFIERGRPETAWAILRKCGYNDSLELHAELLPVPAKQSPDQSIELTNEAMDFLSGIFQLYDLDNDGALQPAELDDLFQTAPDSPWLEDPYKEAAEKTPGGSLTINGFLSEWALMTLLDPRKSLANLTYIGYGHDPASTFSVTRKRSVDRKKQRTERNVFQCFVFGPKKSGKSALLDSFLGRKFSNSYKATMGERYAANVIDQPGGSKKTLILREIPEDRVKKFLTNKESLAACDVAVVVYDSSDVYSWRKAREILMEVARRGEERGYGTPCLLVAAKDDLDPYPMSVQESDRVCMELGIDIPVSLSMKLGEPNSLFSRIVSTAENPHMSIPETESGRRSRNIRQLVNSSLLFVSVGTAVGFAGLAAYRAYSARKNA
What is the function of this protein?
Calcium-binding mitochondrial GTPase involved in calcium signaling during salt stress response (PubMed:16832621).  May play a role in the progression of embryonic cell division, development of haploid male and female gametes, and pollen tube growth (PubMed:21494602).
What are the official names of this protein?
Mitochondrial Rho GTPase 2, AtMIRO2, Calcium-binding GTPase, AtCBG, Miro-related GTPase 2.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial Rho GTPase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Protein: VE7_HPV1
Sequence: MVGEMPALKDLVLQLEPSVLDLDLYCYEEVPPDDIEEELVSPQQPYAVVASCAYCEKLVRLTVLADHSAIRQLEELLLRSLNIVCPLCTLQRQ
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: RS14_BURCM
Sequence: MAKLALIEREKKRARLVAKFAAKREALKAIVEDQSKSEEERYEARLELQQLPRNANPTRQRNRCAITGRPRGTFRKFGLARNKIREIAFRGEIPGLTKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: KTHY_RICPU
Sequence: MNNLKQGKFITFEGGEGIGKSTQSQMLYEYLQSQNTPVILTREVGGTIVAEKMREILVHEELLPMSELLQAMAARYDHMARKIIPALQEGHIVICDRFIDSTVCYQGLELENGIDLVYNLHKTLMPSLMPDITFFIDVEPDTAIKRVNSRNMNNKFDIRGIDFYKTIYYCFKELSNRFPERIKTIKASDLSPLEVHELIKKHL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RQL3_ARATH
Sequence: MKKSPLPVQNVQSSDKNVAGKEALVKLLRWHFGHADFRGKQLEAIQAVVSGRDCFCLMPTGGGKSICYQIPALAKPGIVLVVSPLIALMENQVMALKEKGIAAEYLSSTQATHVKNKIHEDLDSGKPSVRLLYVTPELIATKGFMLKLRKLHSRGLLNLIAIDEAHCISSWGHDFRPSYRQLSTLRDSLADVPVLALTATAAPKVQKDVIDSLNLRNPLVLKSSFNRPNIFYEVRYKDLLDNAYTDLGNLLKSCGNICAIIYCLERTTCDDLSVHLSSIGISSAAYHAGLNSKMRSTVLDDWLSSKKQIIVATVAFGMGIDKKDVRMVCHFNIPKSMESFYQESGRAGRDQLPSRSVLYYGVDDRKKMEYLLRNSENKKSSSSKKPTSDFEQIVTYCEGSGCRRKKILESFGEEFPVQQCKKTCDACKHPNQVAHCLEELMTTASRRHNSSRIFITSSNNKTNEGQYSEFWNRNEDGSNSNEEISDSDDATEAANSVTGPKLSKKLGLDEKLVLLEQAEEKYYERNKQVKKSEKNAISEALRDSSKQRLLDALTRVLQLLACVEEIDSQKGSEFLENECYRKYSKAGKSFYYSQIASTVRWLGTASRDELMTRLSSVVSLAREQEPLEEPLLATEPVENIEEEDDGKTNTVESRVDEPTQELVVSPILSPIRLPQVPSFSEFVNRRKIKQNTLIDKSSEGFDDKKPAKIMKLQ
What is the function of this protein?
3'-5' DNA helicase that may play a role in the repair of DNA.  Exhibits an ATP or dATP-dependent DNA-helicase activity.  Cannot use GTP/dGTP, CTP/dCTP or UTP/dUTP as nucleotide cofactors.  Catalyzes DNA strand annealing.  On nicked Holliday junctions, unwinds the lagging strand.  Cannot act on intact Holliday junctions.
What are the official names of this protein?
ATP-dependent DNA helicase Q-like 3, RecQ-like protein 3, AtRecQ3, AtRecQl3.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ULA1_DANRE
Sequence: MTDPKTSKEQKYDRQLRLWGDHGQEALENAHVCLINATASGTEILKNLVLPGIGAFTIVDGHKVSGEDVGNNFFLSSSAIGKNRAQAATELLQELNSDVSGNFVEESPDKLLDNDCEFFHRFSLVIAVQLPESTCLRLGAVLWEAGVPFLVCRTYGLIGYMRLIVKEHTVVESHPDNALEDLRLDQPFTELKRHVESYDLDNMEKKDHSHTPWIIVVARYLEKWYNENNSQLPKNYKEKEAFRQLLREGILKNENGGLEDEENFEEAIKNVNTALNPTKISSGTQDIFNAEQCENITSQSSSFWVMAHGVRDFVQNEGNGNLPVRGSIPDMIADSDKFIKLQNVYRDKAMRDAAVVSKHVEMLLQSVGKTPESISEQEIKLFCKNAAFLRVVRCRSLADEYSVDTFNKDEITSCMDSPDSEMVLYLMLRSVDRFYQQHSRYPGVYNYQVEEDINKLKLCVNSLLQEYSLNVNVKDDYIHEFCRYGAAEPHTVAAFLGGSAAQEAIKIITHQFVPFNNTFLYNAMSQTSATFQL
What is the function of this protein?
Regulatory subunit of the dimeric uba3-nae1 E1 enzyme.  E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP.  E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity).
What are the official names of this protein?
NEDD8-activating enzyme E1 regulatory subunit, APP-BP1, Amyloid protein-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
Protein: UBID_BLOFL
Sequence: MTYKDLRNFIKTLEYQGELKKIDFPVDPNLEITEIAHRTLKSQGPALLFTNPIGHSIPILCNLFGTISRIELGIGIKNILSLRDIGKLLAFLKEPQIPTGFRDFLSKIPNFRQILNMPIKHVSNAVCQENIWNNAQDIDITQMPIMKSWPGDISIAITWGITITQGFTNKRQNLGIYRHQVLSKNKIIIRWLAHRGGALDFQEWYTHSSEKKFPIAIALGADPATLIGAAIPIPNTLSEYAFSGLLRGSKTAVTKCISSNLYVPAYSEIILEGYINRDDIAVEGPFGDHTGYYNSTEKFPVCTITHITHRNNPIYHSTYTGRPPDEPSILGMAMNELFIPIIQKQFPEIIDFYLPPEGCSYRLAIVTIKKQFLGHAKKIIFGVWSCLNQFMYTKFILVCDDDINARDWKDVIWAISTRMDPARDIIIAENTPIDYLDFSSPISGLGSKMGIDATNKWPGETQRTWGKPIQMNNSIQSRINDIWDQLHIPCNEKPFKHKN
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PRMC_VIBCH
Sequence: MSVTIEAALKAATEQLQQSGSDSPALDAAVLLCHVLAKPRSYLLTWPDKILEKPTLASLELLLARRRAGEPMAYILGEREFWSLPLKVSPSTLIPRPDTERLVELALDKAALIDGELLDLGTGTGAIALALASELPTRQVTGIDLRPEAAELARENATRLAIHNAQFFQGSWFSPLADGTKFALIVSNPPYIEENDPHLSLGDVRFEPKSALVAAENGLADIRHISTHAPHFLLDGGWLLFEHGYDQGVAVRTILRDLGYQNIITEQDYAGHDRVTLGQYKTEREA
What is the function of this protein?
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
What are the official names of this protein?
Release factor glutamine methyltransferase, RF MTase, M.VchAHemK2P, N5-glutamine methyltransferase PrmC, Protein-(glutamine-N5) MTase PrmC, Protein-glutamine N-methyltransferase PrmC.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein: LEU3_CORDI
Sequence: MKLAVIGGDGIGPEVTAEALKVLNAVRDDIEVTDYDLGARRYLRNGELLADADLVSLREHDAILLGAIGAPGEVPPGVLERGLLLKMRFALDHHVNLRPSKLYPTATSPLANPGDIDFVVVREGTEGLYCGNGGTLREGTPHEIASEVSQNTRYGVERVVRDAFERAQNRKKHLTLVHKTNVLVNAGGLWQRTVNEIATEYPEVTVDYNHIDAATIYMVTDPSRYDVIVTDNLFGDILTDLAGAVTGGIGLAASGNIDATGVNPSMFEPVHGSAPDIAGQGIADPTAAILSAAMLLRHVGDESNAQRIEAAVTYDVAERPAGPVKTVEVGDRIVAALQR
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF2B_DICDI
Sequence: MLSAAPKPTPQNKKQSFYNKLWCMVCRIQDPDIIEDYAKGDLICRGCGVVVGDRIVDEHSEWRTFSNSESTGADPNRVGGPINPLLRDSALSTTVGKGSKDSGTLTRLQNKSALGTGDRNLLAAFKEIGRMADHMNLPQTVQDRANELFRFMDDKKSTKGRSVDGMVAAALYIACRQEHLSRTFKEIAALTNVPKKEISRCYKIMKETFASVLNLQTISSEDFTSRFCSTLKLPNDVKKGAEHVSKMAMDMGIVAGKSPISVTAASIYMVSQLSPEKRTQKQIADVSGVSEVTIRNAYKDLYAKRDQLIPSDSPYFSQVQYLPTN
What is the function of this protein?
General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II).  Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA.
What are the official names of this protein?
Transcription initiation factor IIB, General transcription factor TFIIB.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CRGD_BOVIN
Sequence: MGKITFYEDRGFQGRHYECSSDHSNLQPYLGRCNSVRVDSGCWMIYEQPNYLGPQYFLRRGDYPDYQQWMGLNDSVRSCRLIPHAGSHRLRLYEREDYRGQMIEITEDCSSLQDRFHFNEIHSLNVLEGSWVLYELPNYRGRQYLLRPGEYRRYHDWGAMNAKVGSLRRVIDIY
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin D, Gamma-D-crystallin, Gamma-crystallin IIIB.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: CBHC_ASPTN
Sequence: MGRVSSLALALLLPAVQAQQTLWGQCGGIGWTGPTNCVAGAACSTQNPYYAQCLPGTATTSTTLTTTTRVTTTTTSTTSKSSSTGSTTTTKSTGTTTTSGSSTTITSAPSGNPFSGYQLYANPYYSSEVHTLAMPSLASSLLPAASAAAKVPSFTWLDTAAKVPTMGTYLADIKAKNAAGANPPIAAQFVVYDLPDRDCAALASNGEYSIANGGVANYKKYIDAIRAQLLNYPDVHTILVIEPDSLANLVTNLNVAKCANAQSAYLECVNYALIQLNLPNVAMYIDAGHAGWLGWPANIGPAAQLFAGVYKDAGAPAALRGLATNVANYNAFSISTCPSYTSGDANCDENRYINAIAPLLKDQGWDAHFIVDTGRNGVQPTKQNAWGDWCNVIGTGFGVRPTTNTGNSLVDAFVWVKPGGESDGTSDSSSARYDAHCGYSDALQPAPEAGTWFQAYFEQLLKNANPAF
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Probable 1,4-beta-D-glucan cellobiohydrolase C, Beta-glucancellobiohydrolase C, Exocellobiohydrolase C, Exoglucanase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 6 (cellulase B) family.
What are the subcellular locations of this protein?
Secreted.
Protein: DHPS_STAEQ
Sequence: MIKTKIMGILNVTPDSFSDGGQYHSVDQAVKRAKEMIDEGVDIIDVGGVSTRPGHKEVSHKEVSLKEEMNRVLPVVESIVKYDVQISVDTFRSEVAEACLKLGVSMINDQWAGLFDSNMFNVVSQYGAEIVLMHNGDGHRDKPVVEEMLVSLLAQANKAELAGIPHNKIWLDPGIGFAKTREEENEVMARLDELVATEYPVLLATSRKRYIKEMMNQDSSPSDRDEATAATTAYGIMKGVRGVRVHNVLLNTRLAQSMDFLKENEYERHHLS
What is the function of this protein?
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
What are the official names of this protein?
Dihydropteroate synthase, DHPS, Dihydropteroate pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the DHPS family.
Protein: GYRB_MYCTO
Sequence: MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_ENT38
Sequence: MSNRKYFGTDGIRGRVGDAPITPEFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLSAAGLSASFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDEVEEAIEAEMEKELTCVDSSELGKASRIVDAAGRYIEFCKGTFPNELSLSHLKIVVDCANGATYHIAPNVFRELGAKVIAIGCEPDGLNINEEVGATDVRALQARVLAEKADLGIAFDGDGDRVIMVDHEGNKVDGDQILYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKLQEKGWRIGAENSGHVILLDKTTTGDGIVASLQVVAAMVRNHMNLHDLCSGMKMFPQILVNVRFTAGKGDPLENENVKAVMAEVEAALGNRGRVLLRKSGTEPLIRVMVEGEEEAQVTEFAHRIADAVKAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: IGFR1_HUMAN
Sequence: MGPGRCLLTALLLLALAPPPEASQYCGRLEYWNPDNKCCSSCLQRFGPPPCPDYEFRENCGLNDHGDFVTPPFRKCSSGQCNPDGAELCSPCGGGAVTPTPAAGGGRTPWRCRERPVPAKGHCPLTPGNPGAPSSQERSSPASSIAWRTPEPVPQQAWPNFLPLVVLVLLLTLAVIAILLFILLWHLCWPKEKADPYPYPGLVCGVPNTHTPSSSHLSSPGALETGDTWKEASLLPLLSRELSSLASQPLSRLLDELEVLEELIVLLDPEPGPGGGMAHGTTRHLAARYGLPAAWSTFAYSLRPSRSPLRALIEMVVAREPSASLGQLGTHLAQLGRADALRVLSKLGSSGVCWA
What is the function of this protein?
Probable cell membrane receptor for the IGF-like family proteins.  Binds IGFL1 and IGFL3 with a higher affinity.  May also bind IGFL2.
What are the official names of this protein?
IGF-like family receptor 1, Transmembrane protein 149, U2 small nuclear RNA auxiliary factor 1-like 4.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: MNMA_YERPY
Sequence: MSDNSQKKVIVGMSGGVDSSVSAYLLQQQGYQVAGLFMKNWEEDDDEEYCSAATDLADAQAVCDKLGMELHTVNFAAEYWDNVFELFLAEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRQDVDGKSRLLRGLDGNKDQSYFLYTLSHEQIAQSLFPVGELEKPEVRRIAEQLDLVTAKKKDSTGICFIGERKFRDFLGRYLPAQPGPIMTVDGQLVGKHQGLMYHTLGQRKGLGIGGTKEGGDDPWYVVDKDLDSNTLLVAQGHEHPRLMSVGLVAQQLHWVDRQPVTAPFRCVVKTRYRQQDIPCTVTPLDDERVDVRFDDPVAAVTPGQSAVFYQGEICLGGGIIEQRYPLTNPA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_BORDL
Sequence: MKNIIILIINTGSSSLKFTLYEYQYQSEQILASGIIEKIKTTQAIIKIKFKNKFLELTNLNIKSHKKALKHLIKTLTNKKTKIINYLDQIQGIGHRIVHGGAKFKNSVIINQNVLNELKKISHLAPLHNPIAIKVIEEMFILFPNAKQVACFDTSWHQTMNQKAFLYATPYSWYKDYHIRKYGFHGLSYAYITKRTAIILNKNIEDLNLIILHLGNGASINAVQKGRSYDTSMGLTPLEGLVMGTRSGDIDPTIIPLMSKILKKTTKQIENILNKESGMLGISCKSNDLRDIWIESNNNEYNSKLAVEIMTYRIKKYIGSYLAALDFNIDAIIFTAGIGTSDYEIRKLSLQGFEKIGIKIDFQKNNLAIDKNTEYDISSNQSNIKILVIPTNEELTILEDTYDLIKDN
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNP2_METMP
Sequence: MLKTLPPTLREKKRYVALEIIYEMELSQKDVISVVRNALLNYSGVLGCSRTNPWLIDYGHPYGILRISREEVDTLRSSLSLMGEHKKKPINIRIIGISNSVKHIREKFLHVPHEPYYKVIQKLKRKGPKK
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 2, RNase P component 2, Pop5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_MAMHA
Sequence: MEEFKRYIELDRSWQHNFFYPLIFQEYIYGFAYDHGLNKSILLENAGDKKYSLLIVKRLINRMYQQTHLILSANHSNQNDFFGHKHKKNLYYQIISEGFAVIVEIPFSLLLISSPEAEENQIVKSHNLRSIHSIFPFFEDKFLHLNYVLEILIPYPIHLEILVQTLRYWVKDASSLHLLRFFLYEYRNWNSLITPQKSNSIFSKRNQRLFLFLYNFHVCEYESIFFFLCNQSSHLRSTSFGALLERNYFYGKLEYLVKVKTFTKDFCLILWLFKDPFLHYVRYRGKSILASKGTSLLMHKWKYYLLNFWQCHFSLWSQPRRIYINRLSKHSLDFMGFFSSVRLNSSVIRSQMVANSFLIDNRIKKFDTIVRIIPLVGSLAKAKFCNVLGHPISKSVWTDLLDSDIIDRFGRICRNLSHYYGGSSRKKSLYRIKYILLLSCARTLARKHKSTVRAFLKRLGSAFLEEFFTTEEEKVLSLILPRDSSISGGLYRGPFWYLDIICIHDLANDE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CP4B1_HUMAN
Sequence: MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 4B1, CYPIVB1, Cytochrome P450-HP.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.