Protein: SRDA_NEUCR
Sequence: MAPHSTLDSDYSSGSSTPTSASAAGDGFVDGLNGLNNGRAVDPQEPIAIIGMGCRLPGGSHSSSKLWELLKAGRTAQSRFPPSRFNIDGFYHPNSDRPGSLNMEGGYFIEDDIRGFENSFFGINNLEATYMDPQQRKLLEVVFETFENAGFTLDQVSDANIGCYVGNFVTDFITMQLKDSEYTHRYSATGLGTTILANRISHVFNMKGPSFVIDTACSSSLYCLHAAVAALIAGECDSAIVAGANLIQSPEQQLATMKAGVLSKTSTCHTFDSSADGYGRADGIGAILVKRLSDAIRDGDPIRSVIRGTAINSNGKTNGITLPSADGQEAVIRKAYAQAGLGFNETDYIECHGTGTAVGDPIEVEAVSRVFKKPQGAPLLIGSVKSNLGHSEAASGLSSIIKVAMALEKGEIPPTYGVKNINPKIKTDEWNVQIVTETTPWPKNLPHNAGRLFRRAGVNSFGYGGANAHAILEAPQMHVPVGYNRGSLPASLTRSTLFLPFSGSNTAALERRVTDIAAAIDFENVNIADLAYTLGVKRTHLSTRGYILSGQDTLKDDLKPENLRVALQGKTYSKLPLAFVFTGQGAQWPEMGKELMKEFPSFRRTIQRLDAALQMLPHAPTWTLQGAILEPAKTSMINHASRSQPVCTAVQIALVQLLASWGIKPESVIGHSSGEIAAAYTAGYLTPEQSIIIAYYRGHCVTKSTMVGAMMAAGLGAEDANKKISELDLVGKIRVACVNSPESVTISGDTEGIETLRAQFDQAGTFARVLKTDGKAYHSHHMAVIGQEYEDLLTEALDGDDFPTTSNGVRFISSVTDAVVNHAVGPAYWRANLESPVLFANVVERLIKDTASHLVELGPHSALELPIKQTRTKLNISETKVHYGSALSRGKNSITTILNLVGDLFLHGHDISFKGVNYVDSAFNSPKARKNVKTQEKMLLDLPNYTWDYSGTVFNESRVSVEWRNRKYPRHDLLGSQVHGGNGISTNWRNVVKAKDIPWMEGHKLDTTTVFPAAGYLAMAVEAMCQVADVTKEQEPALSLRNVNITKALTLGSEETDAGVELFTTLYPAQLPGGATDAGWYQFNISSYTNGTATTHANGLVKIDSAPAPLEVNLPIVPSTMEPQAPRTWYGKFAKGGLNFQGQFQSLTEIQNPRKKENPHTLAKTELRQGGGSGPSTESEYLIHPITIDALFQAGIIASTSGVVRELRAKVPVHIEEMHLRAPVGGQKELKVNATSEAVGFGTIRVDGELFDDEGRVFLQINRCRQVSYQSGIQQEAGDERHPMLRVVWKPDVTRLGAGDAKEFSQYIEQYAAKSESKVDDATVRLGAALDLLIHKHPRLRILNLDVNLTEFLVDTLRLETDFKKCKTLVSGSYSEDGTLTFEDLTNEGKTSTAAQVFDVVILGSKAQELEAAKELVDENGSIIVNGSPADADKLQTLGFTTLQAPSDTILAQTPQEITAKQQKTLSKQVLIVERNADHVLNSAIAAQAKKITGLEAKRIPLESVTADIIAAHTRVISTIELENPVLSRVTEDEMKHIKTLTDNCTNLVWVTGGRLFQSASPEHAVVYGLSRALMLEQPSLRFFVVDVDHEGTPVERSAKHVVEVLQQALIEADPDYEFVQNAGLLHVSRFVPEETLNRVFREKQGAEKLALPLKDARPFRLGTDMVGQIDSIFFRREEAKDVQLADGHVEVSVKAVGLNTKDLQAINGDGDNTSGSFCTSQYTAVVANVGTGVENLAVGDRVVVMTPGYFATTESVPAWACQKLADNEDFTTLSSVPLQLSTAIYAVNNRAHVQAGESVLVITGSDIAADQAAIRVAQLAGAEVFAVGESTNLPSERVFTKGDKALVAKLLKATEGRGVDVVLNFANDAAPISSIGNVFADCGRLVHVGKSSLAEAIATDSTLFRKSVTVTTFDIANILSLKTVAGQKIRSQLLADSIALYRQGQLNLASSPKVFDVSEVRDAFRALAAKGHSGSVVVSLENEASLVPTLPLKYDTVLSPEKSYLLVGCLGGLGRSMSKWMLARGARKFVFMGRSGTDRAPARRLVEDLELAGAQVTVVRGDVINMEDVELAVNGIDGPIGGVIQAAMGLDEALFTTMPRDYWLTGLKPKIVGSWNLHNAIRGRDSELDFFLMTSSISGSVGTATESNYCSANYFLDVFARHRHSLGLPATSIGLGMISEVGYLHENPEIEAMLLRKGIQAINEDEMLQIIDASLATPTAVPGSYDELARAHVLTGLEPLGLKELRAKGFEGTSPVLGDPRASLLSAALDESTDAASSNAASGMPAEVAEAIATGASVEDAVLKMISKKFSNLVLIPEDKLNLTKPISEVGVDSMLAAEFRAWIFQAFKVDVPYLTLLSAAATLTLLSELITKKMMEAQDA
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040).  The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040).  SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040).  The polyketide chain is then reductively released as an aldehyde (PubMed:30908040).  The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040).  This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040).  The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040).  This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).
What are the official names of this protein?
Highly reducing polyketide synthase srdA, HRPKS sdrA, Polyketide synthase gene cluster 6 protein pks-6, Sordarial biosynthesis cluster protein srdA.