PharMolix/UniProtQA huggingface dataset:
Protein: VP40_EBOZ5
Sequence: MRRVILPTAPPEYMEAIYPVRSNSTIARGGNSNTGFLTPESVNGDTPSNPLRPIADDTIDHASHTPGSVSSAFILEAMVNVISGPKVLMKQIPIWLPLGVADQKTYSFDSTTAAIMLASYTITHFGKATNPLVRVNRLGPGIPDHPLRLLRIGNQAFLQEFVLPPVQLPQYFTFDLTALKLITQPLPAATWTDDTPTGSNGALRPGISFHPKLRPILLPNKSGKKGNSADLTSPEKIQAIMTSLQDFKIVPIDPTKNIMGIEVPETLVHKLTGKKVTSKNGQPIIPVLLPKYIGLDPVAPGDLTMVITQDCDTCHSPASLPAVIEK
What is the function of this protein?
Plays an essential role virus particle assembly and budding.  Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101.  The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding.  May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis).
What are the official names of this protein?
Matrix protein VP40, Ebola VP40, eVP40, Membrane-associated protein VP40.
What is the protein family that this protein belongs to?
Belongs to the filoviridae matrix protein VP40 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane. Virion membrane; Peripheral membrane protein. Host late endosome membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein. Secreted, extracellular exosome. Note=In virion, localizes on the inner side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and probably also in multivesicular bodies. These VP40-enriched membrane clusters are then redistributed to the plasma membrane where budding takes place.
Protein: DBP4_LODEL
Sequence: MVKSQRNGKKGAKVLSRKEKRQSEKEEMDSLRQRIEEYNPEVDEASIKHFSDLPITQNTLRGLKECSFVSLTDIQKKSIPVALKGEDLMGTARTGSGKTLAFLIPVIEILLRNDITEYDGLAALIVSPTRELAVQIFEVLAKIGKYNSFSAGLVTGGKDVQYEKERISRMNILVGTPGRISQHLNESVGMETSNLQVLVLDEADRCLDMGFRKQIDNILNHLPRTRQTLLFSATHTDSVQDLARLSLTNPKRIGTSSDQDISAIPESLDQYYVKVPLNEKLDVLWSFIKSHLKSKILVFFSSSKQVQYAYETFRTLQPGIPLMKLYGRHKQTSRLETTVKFSQAQHACLFATDIVARGLDFPAIDWVIQVDCPEDVATYVHRVGRSARFGRQGKSLLMLLPTEEDGMLKRMKVHKIEPKMMNIKEKSKKSIRPQLQSLCFKDPVIKNLGQRAFIAYFRSVYIQKDKDIFKVDELPVEEYAASLGLPGAPKIKIKGGEINKEKKNQSRKLLQLSKADENGELKEDDDKPAKVRTKYDRIFDRKNQTILSEHYLNMTKSAHGGKDDDEDEDFMTVKRQDHELVDDELPDLLLPVSKRQAKKALSRKATLASKGNPTKLKFDDDGVPHAIYELEGEEDFEKAGDAKQQKMEFVQKEQEAMKITDLADREVERQKRQEKKRKRKEIERRIREEEWDDGSGMDGEDLPDLERDMEPTEAKPKRTSNWFDDDDDDNDGGDEKHGNGKPPVKKAKSDSKYVEFEEPETLEDLESLAATLIGN
What is the function of this protein?
ATP-dependent RNA helicase required for ribosome biogenesis.  Involved in the release of U14 snoRNA in pre-ribosomal complexes.  Required for pre-rRNA cleavage at site A2 (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DIF1_CAEEL
Sequence: MSDVLLNFIAGGVGGSCTVIVGHPFDTVKVRIQTMPMPKPGEKPQFTGALDCVKRTVSKEGFFALYKGMAAPLVGVSPLFAVFFGGCAVGKWLQQTDPSQEMTFIQNANAGALAGVFTTIVMVPGERIKCLLQVQQAGSAGSGVHYDGPLDVVKKLYKQGGISSIYRGTGATLLRDIPASAAYLSVYEYLKKKFSGEGAQRTLSPGATLMAGGLAGIANWGVCIPADVLKSRLQTAPEGKYPDGIRGVLREVLREEGPRALFKGFWPVMLRAFPANAACFFGLELTLAAFRYFGIGGHPTPSTEVVPLPHDE
What is the function of this protein?
Seems to play a role in the maintenance of tissue differentiation in the developing embryo, but not for its initiation.
What are the official names of this protein?
Protein dif-1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EIF3H_CHAGB
Sequence: MCRASRRRSSHLYVPSQISDKDQVPRHHCSSSFPTTATGSIVGMDNNGVIEITNAFPFPTVDVSGTDSHQSDATSLAAAAPRAKANIAYQNEMIRHLKEVNVDANNVGWYTSATMGNFINLSFIENQHHYQRDNDKTVALVHDVSRSSQGALSLRAFRLSPEFMAAFKEGKFTTESLQKSKLTFRDILVEVPVVVHNSHLLTSFLHQIPAPPKSAEIPLPASLEDIRRDPAQLPAHPSFDTLDLSIDPFLEKTCDLLLDSIESHYSDLNNHQYYQRQLTREQFKITQWQTKRKAENAARLAAKQQPLPEDEWQRLFKLPQEPSRLEGMLNARQVEQYSKQVDGFTASITTKMFAVRGNLLPE
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit H, eIF3h.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBD_PSEAE
Sequence: MSALLGILGVVLDARFGEPQGWHPLVAFGRLADRLERRFNRSRLAGEADPGVGWRSHGVTAWVLAVLPLTLLAWALAELPYLGWLVQALALYAALGLRSLGEHAEPVALALRAGDLDEARRRVGYLVSRDTRELDQAGVARAATESVLENGSDAVYAALFWFAVAGAPGVVLYRLSNTLDAMWGYRNARFERFGWAAAKIDDILNYLPARLVALTYALLGDTRQALRCWREQAPQWDSPNAGPVMAAGAGALGVFLGGAAIYHGELHQRPLLGSGPQPQGRDIYRALALVRQGVLLWLLVLAGLWAMGWLHA
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RK21_CYACA
Sequence: MTNYAIVKASGRQLWFEPGKYYNINYVHANPGDKIIFYKVLLLKNTNSLLIGKPFVEKVEVHATILQHLKDKKITVFKMQAKKGTKKKKGYKTVLTKIKINCIHNHKK
What is the function of this protein?
This protein binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L21, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EZRA_STAAM
Sequence: MVLYIILAIIVIILIAVGVLFYLRSNKRQIIEKAIERKNEIETLPFDQNLAQLSKLNLKGETKTKYDAMKKDNVESTNKYLAPVEEKIHNAEALLDKFSFNASQSEIDDANELMDSYEQSYQQQLEDVNEIIALYKDNDELYDKCKVDYREMKRDVLANRHQFGEAASLLETEIEKFEPRLEQYEVLKADGNYVQAHNHIAALNEQMKQLRSYMEEIPELIRETQKELPGQFQDLKYGCRDLKVEGYDLDHVKVDSTLQSLKTELSFVEPLISRLELEEANDKLANINDKLDDMYDLIEHEVKAKNDVEETKDIITDNLFKAKDMNYTLQTEIEYVRENYYINESDAQSVRQFENEIQSLISVYDDILKEMSKSAVRYSEVQDNLQYLEDHVTVINDKQEKLQNHLIQLREDEAEAEDNLLRVQSKKEEVYRRLLASNLTSVPERFIIMKNEIDHEVRDVNEQFSERPIHVKQLKDKVSKIVIQMNTFEDEANDVLVNAVYAEKLIQYGNRYRKDYSNVDKSLNEAERLFKNNRYKRAIEIAEQVLESVEPGVTKHIEEEVIKQ
What is the function of this protein?
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation.  Inhibits FtsZ ring formation at polar sites.  Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
What are the official names of this protein?
Septation ring formation regulator EzrA.
What is the protein family that this protein belongs to?
Belongs to the EzrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Colocalized with FtsZ to the nascent septal site.
Protein: SDHD_ECOHS
Sequence: MENAKMNSLIAQYPLVKDLVALKETTWFNPGTTSLAEGLPYVGLTEQDVQDAHARLSRFAPYLAKAFPETAATGGIIESELVAIPAMQKRLEKEYQQPISGQLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALEAGLLTLDDDYSKLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEQDYGVAVEEGRKAAQSDPNCFFIDDENSRTLFLGYSVAGQRLKAQFAQQGRIVDADNPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCFFAEPTHSPCMLLGVHTGLHDQISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGFYTLSDQTMYDMLGWLAQEEGIRLEPSALAGMAGPQRVCASVSYQQMHGFSAEQLRNATHLVWATGGGMVPEEEMNQYLAKGR
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: DPO4_STAA9
Sequence: MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGLTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTNKNMTIYDFI
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_SHESA
Sequence: MADTTVEKLATEVGKSVERLIEQFSQAGIKKGQTDNVSEAEKQQLLDYLKKQHGGESAPTKMTLQRKTVSTLSVAGNGGQSKDVKVEVRKTRTFVKRDVSEAVLKAEEEAKAKAEAEAQAKAEAEAKARAEAEAKAKADAEAKAEAKAKADAEAKAKAKAATDAKTTKDTSPEAEAARVEAERLKAAQAEATKRKQDEEAAKAAEKARLLAEENSKRWDEEERQRKEAERYSDHHITTSKVARAAEDSSDMDEEKRGRRARNKNTAKTKRGGKDARDGREKHMRNRSTAPESMAHGFNKPVAAVTRDVRIGETVTVAELAHLMAVKATEIIKQMMKMGSMVTINQVLDQETAQLVAEEMGHKVVLIRENELEQQVLSERDEEGGVKLEPRAPVVTIMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTAMRARGAKATDIVVLVVAADDGVMPQTIEAIQHAKAGNVPLIVAVNKMDKPEADIDRVKSELAQHGVMSEDWGGDNMFAFVSAKTGAGVDDLLEGILLQAEVLELKAVRDGMAAGVVIESQLDKGRGPVATILVQEGTLRQGDIVLCGLEYGKIRAMKDENGRSITEAGPSIPVEILGLSGVPSAGDEATVVRDERKAREVALYRQGKFRDVKLARQQKSKLENMFANMTEGEVKELNIVLKADVQGSLEAITDSLMGLSTDEVKVNIIARGVGALTETDATLAAASNAIMVGFNVRADAQARKTIESESVDLRYYSVIYNLIDEVKAAMTGMLSPEFKQQIIGLAEVRDVFKSPKLGAIAGCMVTEGTIKRSAPIRVLRDNVVIFEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRVGDQIEVFETVEVARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_ANADE
Sequence: MVRDRVIELFRKALAQGADDGRWPAADAGFSVEAPRDPKHGDFAVNAAMVLAKQAGKPPRELAQAIVEAVRAADTAGDLAGLEIAGPGFINVRLSPDLWLRTLARAVAEGPAYGRTAVGQGKKVIVEYVSANPTGPMHVGHGRNAVVGDGVQGLLRWAGFDVSREYYVNDYGAQVQTLARSVHLRYQELHGRAVTMPPKSYPGEYVKDIAAGLKAEYGARFLDAPEAEWLTLFRDHAVQHVLGMIREDLAAVNISFDRWSSEKALYESGTVDRFLRFLEEKDLVYVGKLPPPKSKKGQPPPQAQPDEEGVTAAEDLTLFRSSAYGDEVDRPVKKADGTPTYFCADIAYHWDKRQRADALVDVLGADHGGYVPRLEAAMEALGASRKDLHVVLIQMVSLMRGGESVKMSKRAGTLVSLREVVDEVGRDATRFIFLTRRSDAPLDFDVELAKKQTLDNPVFYVQYGHARLAAIFQKAREAGHAVPEFDLDAARTLGSPEEQDLIRRIAAFPDLLAAAALAYEPHRVAFYLQETIAAFHSWYTQGKKSGEKVIGPDPVKTAARLFLCRALKQVLANGLAVLGVSAPDRMESPETRDIADDV
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX90D_PHONI
Sequence: MKYRIFKMKYTLLFLSVIALVHIFAVEAKDEPESDALVPQERGCLDIGKTCKDDCECCGCGNVCYCPFDWFGGKWQPFGCSCAYGLKYVCAHKQKKCPNV
What is the function of this protein?
Probable neurotoxin.
What are the official names of this protein?
U12-ctenitoxin-Pn1a, U12-CNTX-Pn1a, Neurotoxin Pn3-6B.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 09 (Tx3-6) family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOH_THERP
Sequence: MDWQRLIVSYLVGFVLLNVLLGLMAYMTWFERRVLARMQHRVGPNRTGPFGLLQPIADGIKLLAKEDIVPANADRLVFLVAPLLSFALAPLGAAVIPFGDTLQLFGIEIPLLVADINVAVLYVLALGSVGVYGIILGGYASGNRYSLLGALRSTAQVISYELVLGLSLVGVFILSGSLSLQDILREQQRMLVLGPLTLPNWYILSQPLAFALFLIAAVAETNRAPFDLPEAETELVAGYFTEYSGFRFSFYFLAEYINMIVVSLLAATLFLGGIDGPFADGVWWLALKALFFLFFYVWLRATLPRFRYDQLMGLAWKVLLPLALLNIGLTGLVRLWGIGAL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNPH_SHIBS
Sequence: MRPAGRSNNQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFLKGQGQGWITAEYGMLPRSTHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVLQADGGTRTASITGACVALADALQKLVENGKLKTNPMKGMVAAVSVGIVNGEAVCDLEYVEDSAAETDMNVVMTEDGRIIEVQGTAEGEPFTHEELLTLLALARGGIESIVATQKAALAN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: MURD_CLOBB
Sequence: MREDFKKFKDFIYKKRVGVVGIGVSNIPLINFLIKLGAEVTAFDKKTEEELGEVSSDFKNKGVNLELGDNYLDKLTGFDVVFKTPSMRIDSECLVKVKKEGAYVTSEMEEFVRYCKAKIYGITGSDGKTTTTTIISKMLQEEGYKTWVGGNIGTPLFAQIEEIKSEDRVVLELSSFQLMTMNLPMDIAVCTNLAPNHLDMHKDMQEYIDAKKNIFLYQDATNTLIVNRENEITYGFKAEAKGVVREFSSKRELKEGAYYKDGILYLSGKEVCKKDNIVIKGMHNVENYLAAFIATKNDVSIENMKKVAESFNGVEHRCELVREINGVKYYNDSIASSPTRTLAGLKAFDKRVILIAGGYDKHLLFEPLANEGYPYIKELILLGQTKEKIKDVFKELEASKGIKINISEVSTLEEAVKKAQNLARQGDIITLSPACASFDMFPNFMIRGNKFKEIVNEL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICMT_ORYSI
Sequence: MAARAQAWLFAAALVIFHGSEYVLAAAFHGRRNVTATSLLISKQYVLAMSFAMLEHLTEALLFPELKEYWFVSYVGLVMVIIGEVIRKLAVVTAGRSFTHVIRIHYEDQHKLITHGVYRLMRHPGYSGFLIWAVGTQVMLCNPLSTVAFTLVLWRFFSKRIPYEEFFLRQFFGREYEEYAQKVHSGLPFIE
What is the function of this protein?
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.  Carboxyl methylation is a reversible and potentially regulated step in the post-translational modification of prenylated proteins (By similarity).
What are the official names of this protein?
Probable protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine carboxylmethyltransferase, Prenylated protein carboxyl methyltransferase, Prenylcysteine carboxyl methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: KAD_VIBPA
Sequence: MRIILLGAPGAGKGTQANFIMDKYGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEMGVEVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVVRDDDKEETVRARLGVYHEQTAPLIDYYGKEAAAGKTKYLKFDGTKQVAEVSADIEKALA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_TRIEI
Sequence: MSAKKLTGNEIRKKFLSFYAQREHTILPSASLVPEDPTVLLTIAGMLPFKPIFLGQQPRQYPRATTSQKCIRTNDIENVGRTARHHTFFEMLGNFSFGDYFKPEAIALAWELSTKIFALPPERLVVSVFREDDEAFAIWRDQIGIPAHRIQRMDEADNFWASGPTGPCGPCSEIYYDFHPELGDDHIDLEDDTRFIEFYNLVFMQYNRDANGNLTPLENRNIDTGMGLERMAQILQKVPNNYETDLIFPIIKTASDIADIDYRKSDDKTKVSLKVIGDHVRAVANLIADGVTASNVGRGYILRRLIRRVVRHGRLIGISGEFTSKVAETAITLAEDIYPNLRERETVIKAELQREESRFLETLERGEKLLAEIMAKPETKKTQHISGEDAFKLYDTYGFPLELTQEIAEENGLTVDVSMFDQEMKLAQIRSQSAHETIDLTAQDGVKLDIDKTQFLGYTDLSSPAQVMALVGDGEQLETVQAGAQVQIVLDKTPFYAESGGQIADRGYLSGDSLVVRIEDVQKQNNIFVHFGRIERGRLQLGMTVNAQIDGTCRRRAQANHTATHLLQAALRSLVDSSISQAGSLVSFDRLRFDFNCPRGLKPEEVEQVEAQVNSWIAEAHSATVAEMPLEVAKAKGAVAMFGEKYADVVRVVDYPGVSMELCGGTHVNNTAEIGVFKIISEAGISSGVRRIEAVAGLAVLDYLKVRDAVVKELSDRFKAKPEELSERVSNLQQELKDSQKQLEALKGELAVAKSDQLLGNAETVGEFQILVAEMPGVDAEALKTAAERLQQKLDESAVVLGSAAEGKVSLVAAFSKSVNGKGLQAGKFIGGIAKICGGGGGGRPNLAQAGGRDPSKLKEALESAKEQLVDGLK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DESPA_DANRE
Sequence: MSLSGSQTRLHQISRRSSSRPDLTAVGYSLPRNDGAQFFTSGNGYQSDYNDGYMQTYTQTFSKNSQGGGAGGAQSMSSMAVQKRAQMLYSDCMGFLQRAQGLLETMGPASEVDKNMMAAQDAMDQLRKCAVDMRNAGLPNDMILRSLEDCHSFYADIRNSITGTTIRRTGGTVSGTIGGTISGTIGGTVGGWDDPSKSFQDALSWINQKKRLIETSGFGENSEAISQQILNHNKFHSSIQRSQEVDRARDDLMQSREKAGLHALDQEWDSLQKMSHARMDHLRDLQSIIEEISRAIMWVNDREEEELVFDWGDKNIDNYIPQKQESYSKLMSDLEEKEKELNKLKAKVDMLLKNQHPASDKIEAYMDTLQTQWSWLLQITKCIHVHLKENAAYSQFFKEANETYSRLQKDHENIRKKFGCDKTTPLENLNDMLKNLEKEKEKVIENKRQVQTLVSKSKNIVCLKPRNPEEKSSSPVIVQALCDFKQDQKGIMKGNEGILKDNSQRSKWHVTGPGGLEMLIPSVCLIIPPPNPLSISLANKNEQYYEAIMSIWSQLYINIKSLISWQYCLRDIQHINSLTLSMLTQMRPEEYRQTIKNLEIHYQEFLRNSLGSEMFGDDDKRKMELQYAGAQSHYDQLVIQLPNYRENGVIREVVMVETDSKLKSEVSSGKTATGVSSGKTATGVSSGKTSSSVSVSGLNVSLLSDLSALRRRLETAESGLTKHLHVPLKENSVQECSQRLAQLQAVHRDLDSIRDEYLHLREKIMRELEGSSDPEQSRYLRAELDLINQKLGSLQGFSSAYIQRLGALQALLQHLLQAEDIIKVHEARLTEKETSSLDLNEVEKYCMTLKTMKAELEQKKGVLKAMETELSKAVHWNSQIDQSFHQCDVDLSRYTELVGQMTDRWRRIVTQIDSRTWDLEKQEKQLNHYQQTSSTINRWIQDTRQRQDTLQITKFNSVDNLMDHLNQQKALYSEIKGKKEKVDAVVKDSDTCAASIKDYELQLASYSAGLETLLNIPIKKTMLQSPATVLREEATDLQSRYIELLTRSSDYYKFLGEMLKNMEELKMRNTKIELLEEELRRLKDNLKDQNQKNKSLEDSLTRFRLELTQSKEQLISMEEVKRTQARQCNTAQESLDSTQNQLKSLQDEMSRLTFLIEEEKRKRRLAEERYTNQQEEYELAMRKRQKELEELTLSKSQFERAIKEKEREIERLKLQLQDEASRRSAAELETSKTSMMIQRSDSNYKDIVQERDSLLIKLKLLQQDKDKQQRYEEELRRIKLTLESETKQKQRLQDEIDKITKDFKYWKSQYELKEGQIRQSEMDRDRVERDRASLQSEIQRLTAELRSVEERYRGRLQSSDKEISELMRKKESLEIELRRLQQRPAATWKQTQTDEISKPVVEQKLTVQGLRGEVSLTELVESDLLDQTDLDKINRGQLTSKDIEHKLKSYLGGSDCIAGIYDEAKDRVMPFYQAMKDGLLRRGTTLELLEAQAASGFIIDPVNNVCMTVEEAWKRGLVGKEFKDKLLSAEKAVTGYKDPATGKIISLFQAIEKEIIEKGHGIRLLEAQIASGGIIDPKGSHRIDVEVAYRKGYFDREMNEILSYEGDDTKGFFDPNTHENLTYLELKKRCIKDPKTGLMLLPLNDKQKPKQTTTQKNTLRKRRVVIVDPDTGKEMTVREAYHRELIDYDTFLELSEQECEWEEITIETSDGNKRLLIVDRKTGIQYDIQESLQRGIINKQTLEKYRAGTMTLTEFAALITSKSNSSELAIFSSSPEDVATCSSPTQPSSPTVRKRFASVSITLSPPSDIFDDQSPVGAIFDTETLEKITIPEAQRRGIVDNITAQRLLEAQVCSGGIINPATGQRLSLKDAVQQSLIDEDMSVKLKPAQKAYDGFEDVKTKRKLSAAEAMKEKWLPYEAGQRFLEFQYLTGGLIEPGTGRRVSIEEAIRKGWLDGKGAQKLQDTRNYIKNLTCPKTKLKISYKEAMDNCMVEENNGMKMLQATSMSTKGISSPYNVSSGPSSRSGSRAGSRTGSRSGSRRGSVDYSSSSVSYTFFSSAS
What is the function of this protein?
Involved in the organization of desmosome cell-cell junctions (PubMed:29522173).  Of particular importance in cell adhesion in the skin and during cardiac development (PubMed:29522173).  May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways (PubMed:29522173).
What are the official names of this protein?
Desmoplakin-A, Desmoplakin isoform X2.
What is the protein family that this protein belongs to?
Belongs to the plakin or cytolinker family.
Protein: AROE_STRU0
Sequence: MSERLSGHTLLISLIATPIRHSLSPKMHNEAFAKLGLDYAYLAFEVGNEELADAVQGIRALGIRGSNVSMPNKQAIIPYLDEISPAAELVGAVNTVVNKDGKGHLVGHVTDGTGAVRALAEEGVDIKDQIITLSGAGGAGTAIAVQLGLDGAKEVRIFNQKDAAFANAEKTVEKINSRTQTKASLTDLADQEAFKKSIAESSIYIDATGVGMKPLEDMSLITDPEVIRPDLVVFDVVYSPAETKLLKFAKEHGAKKAINGLGMMLYQGAEAFKLFTGEDMPVDYIKDLLFNDQDK
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: RUVB_FRACC
Sequence: MSDDGLVSAAASPEERAFEAGLRPRTLAEFVGQRKVREQLTIMLEGARARGRPPDHVLLSGPPGLGKTSLAMIMAQELEVPLRMTSGPAIERAGDLVAILTALSPGEVLFLDEIHRIARPAEELLYAAMEDFRVDVILGKGPGATAIPLDVSPFTLVGATTRSGLLTGPLRDRFGFTAHLDFYDADELARVLTRSAGLLGVTLTAEGAAEVAGRSRGTPRIANRLLRRVRDYAEVRADGVVTREIAQAALRIYDVDGLGLDRLDRAVLEALVTRFGGGPVGLTTLAVSVGEEPETVEDVAEPFLLRAGLLIRTARGRMATPAAFEHLGLDPVTDPLGRTQVSLFTEGE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.