PharMolix/UniProtQA huggingface dataset:
Protein: ATG4_YEAS7
Sequence: MQRWLQLWKMDLVQKVSHGVFEGSSEEPAALMNHDYIVLGEVYPERDEESGAEQCEQDCRYRGEAVSDGFLSSLFGREISSYTKEFLLDVQSRVNFTYRTRFVPIARAPDGPSPLSLNLLVRTNPISTIEDYIANPDCFNTDIGWGCMIRTGQSLLGNALQILHLGRDFRVNGNESLERESKFVNWFNDTPEAPFSLHNFVSAGTELSDKRPGEWFGPAATARSIQSLIYGFPECGIDDCIVSVSSGDIYENEVEKVFAENPNSRILFLLGVKLGINAVNESYRESICGILSSTQSVGIAGGRPSSSLYFFGYQGNEFLHFDPHIPQPAVEDSFVESCHTSKFGKLQLSEMDPSMLIGILIKGEKDWQQWKLEVAESAIINVLAKRMDDFDVSCSMDDVESVSSNSMKKDASNNENLGVLEGDYVDIGAIFPHTTNTEDVDEYDCFQDIHCKKQKIVVMGNTHTVNANLTDYEVEGVLVEKETVGIHSPIDEKC
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: SFI1_HUMAN
Sequence: MKNLLTEKCISSHNFHQKVIKQRMEKKVDSRYFKDGAVKKPYSAKTLSNKKSSASFGIRRELPSTSHLVQYRGTHTCTRQGRLRELRIRCVARKFLYLWIRMTFGRVFPSKARFYYEQRLLRKVFEEWKEEWWVFQHEWKLCVRADCHYRYYLYNLMFQTWKTYVRQQQEMRNKYIRAEVHDAKQKMRQAWKSWLIYVVVRRTKLQMQTTALEFRQRIILRVWWSTWRQRLGQVRVSRALHASALKHRALSLQVQAWSQWREQLLYVQKEKQKVVSAVKHHQHWQKRRFLKAWLEYLQVRRVKRQQNEMAERFHHVTVLQIYFCDWQQAWERRESLYAHHAQVEKLARKMALRRAFTHWKHYMLLCAEEAAQFEMAEEHHRHSQLYFCFRALKDNVTHAHLQQIRRNLAHQQHGVTLLHRFWNLWRSQIEQKKERELLPLLHAAWDHYRIALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQKMFQHRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVACAHHRHGRLKKAFCLWRESAQGLRTERTGRVRAAEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALRRWKENTMARVDEAKKTFQASTHYRRTICSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWAFSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRAGPGLSTAGSLDLEAELEEIQQQLLHYQTTKQNLWSCRRQASSLRRWLELNREEPGPEDQEVEQQVQKELEQVEMQIQLLAEELQAQRQPIGACVARIQALRQALC
What is the function of this protein?
Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.
What are the official names of this protein?
Protein SFI1 homolog, hSFI1.
What is the protein family that this protein belongs to?
Belongs to the SFI1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized close to the centriole.
Protein: SYD_YERPN
Sequence: MRTEYCGQLNLSHVGQSVTLCGWVNRRRDLGGLIFIDMRDREGIVQVFFDPDHKAAFEQASELRNEFCIQITGTVRARPDSQINKDMSTGEVEIFANTLNIINRSEPLPLDSNQINSEEQRLKYRYLDLRRPEMADRLKSRAKITSFVRRFMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMSADQVREVMEKLVRELWQETKGVDLGDFPVMTFAEAMRRYGSDKPDLRNPLELVDVASLVKDVEFKVFSGPANDAKGRVAALRVPGGAQLSRKQIDEYGQFVGIYGAKGLAWLKVNDRAAGLEGVQSPIAKFLSAEVLDAILVATQAESGDILFFGADSYKIVTDAMGALRLKVGRDLELTRLGTWAPLWVVDFPMFEDDSEGGLTAMHHPFTAPKDMSPEQLAAAPTTAIANAYDMVINGYEVGGGSVRIHRTEMQQTVFGILGITEDEQREKFGFLLDALKFGTPPHAGLAFGLDRLVMLLTGTDNIRDVIAFPKTTAAACLMTDAPSFANPASLQELSISVVAKKGTTDAGAEENQ
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRA_BASAL
Sequence: GADFQECMKEHSQKQHQHQG
What is the function of this protein?
Possesses antifungal activity against B. cinerea, M. arachidicola and F. oxysporum but not C. comatus and R. solani.  Inhibits HIV-1 reverse transcriptase and cell-free translation.
What are the official names of this protein?
Alpha-basrubrin.
Protein: SYR_STAAE
Sequence: MNIIDQVKQTLVEEIAASINKAGLADEIPDIKIEVPKDTKNGDYATNIAMVLTKIAKRNPREIAQAIVDNLDTEKAHVKQIDIAGPGFINFYLDNQYLTAIIPEAIEKGDQFGHVNESKGQNVLLEYVSANPTGDLHIGHARNAAVGDALANILTAAGYNVTREYYINDAGNQITNLARSIETRFFEALGDNSYSMPEDGYNGKDIIEIGKDLAEKHPEIKDYSEEARLKEFRKLGVEYEMAKLKNDLAEFNTHFDNWFSETSLYEKGEILEVLAKMKELGYTYEADGATWLRTTDFKDDKDRVLIKNDGTYTYFLPDIAYHFDKVKRGNDILIDLFGADHHGYINRLKASLETFGVDSNRLEIQIMQMVRLMENGKEVKMSKRTGNAITLREIMDEVGVDAARYFLTMRSPDSHFDFDMELAKEQSQDNPVYYAQYAHARICSILKQAKEQGIEVTAANDFTTITNEKAIELLKKVADFEPTIESAAEHRSAHRITNYIQDLASHFHKFYNAEKVLTDDIEKTKAHVAMIEAVRITLKNALAMVGVSAPESM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_SALCH
Sequence: MTTLTLNTSLLSSRRILAAFSGGLDSTVLLHQLVLWRERHPDVTLRAIHIHHGLSPHADSWVRHCETVCERWQVPLVVERVTLADNGLGIEAHAREARYRAFAQTLLPGEVLATAQHLDDQCETFLLALKRGSGPAGLSAMGERSPFAGTLLLRPLLRETRKTLEQWAVRHGLCWIEDESNQDDAYDRNFLRLRALPLLQQRWPHFPAAVARSATLCAAQERLLDELLASDLTDCITTEGTLRLSPLMSMSDVRRAAILRRWLAMRNAPMPSRDALERIWQEVALARDDASPCLRFGDHEIRRYQSQLWWIKSVAGQHETTVAWPAWQTPLALPAGLGTVQLVPGGELRRPREEESVSIRFKAPGVLHIVGRNGGRKLKKIWQEQGIPPWRRDTTPLLFYGETLIAAAGVFVTREGAAEDKEGVSLVWHA
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_APOUR
Sequence: MTNIRKTHPLLKIINHSFIDLPTPSNISSWWNFGSLLGMCLTIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYTFMETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALVIVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDILGVLMMISFLMTLVLFFPDLLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILALLPFLHTSKQRSLMFRPITQTLYWILVANLLILTWIGGQPVEHPFIIIGQLASISYFSIILVLMPISGIIEDKMLKWNL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y1711_MYCTO
Sequence: MMAEPEESREPRGIRLQKVLSQAGIASRRAAEKMIVDGRVEVDGHVVTELGTRVDPQVAVVRVDGARVVLDDSLVYLALNKPRGMHSTMSDDRGRPCIGDLIERKVRGTKKLFHVGRLDADTEGLMLLTNDGELAHRLMHPSHEVPKTYLATVTGSVPRGLGRTLRAGIELDDGPAFVDDFAVVDAIPGKTLVRVTLHEGRNRIVRRLLAAAGFPVEALVRTDIGAVSLGKQRPGSVRALRSNEIGQLYQAVGL
What are the official names of this protein?
Uncharacterized RNA pseudouridine synthase MT1751.1, RNA pseudouridylate synthase, RNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.
Protein: RL3_COXBR
Sequence: MSIGLIGRKCGMTRIFTETGSSIPVTVVEVILNRITQVKTVETDGYRAFQVAYGKKSSARVNKPLAGHYSKAAVEAGNALREFRLGNEELTEAKAGDELKVDIFKEGQVVDVRGLTRGKGFAGTVKRHNFRTQDATHGNSLSHRAPGSIGQCQTPGRVWKGKKMAGQLGNVYCTVQSQEIIKVDVERNLLLIKGALPGAPGGEVIITQSSKKRKEDK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: CYAY_SALDC
Sequence: MNDSEFHRLADALWLTIEERLDNWDGDSDIDCEINGGVLTLSFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWVCDRSGETFWDLLEQAATQQAGEKVSFR
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: ATPK_YARLI
Sequence: MIFRRQLSTLIPPKVASPATLHGAPNAKRMADVVSFYKALPQGAAPALPKTANPFKLYYRKYFHPKSGKASGAPLLHLILGIFLFGYISDYQFHLKHHKNGAH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:25759169).  F-type ATP synthases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:27373333).  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (PubMed:27373333).  Part of the complex F(0) domain (PubMed:27373333).  Minor subunit located with subunit a/ATP6 in the membrane (PubMed:27373333).
What are the official names of this protein?
ATP synthase subunit f, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase F chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Note=The F-type ATP synthase complex is anchored in the mitochondrial inner membrane via the F(0) domain with the F(1) domain and the peripheral stalk extending into the mitochondrial matrix.
Protein: KATG_PSEU2
Sequence: MSTESKCPFNHAAGGGTTNRDWWPKQLNLKILHQHSTLSDPMGENFDYAKEFKSLDIEAVKQDLRNVMTQSQDWWPADFGHYGPLFIRMAWHSAGTYRTGDGRGGAGAGQQRFAPLNSWPDNVSLDKARRLIWPVKQKYGRKISWADLIVLTGNVALESMGFKTFGFSGGRADVWEPEEDVYWGSETTWLGGEERYGAQKKMQQPGDGTLVAEPENHANEESRTASGERNLENPLAAVQMGLIYVNPEGPEGVPDPVASARDIRETFGRMAMNDEETVALIAGGHAFGKTHGAGPADNVGPEPEAAGLEEQGLGWRNKFGSGKGGDTITSGLEVTWTSTPTKWSNEYLENLFGFEWELTKSPAGAHQWTPKNGAGAGKIPDAHDPSKRHAPSMLTSDLALRFDPAYEQISRRFLNNPEQLADAFARAWFKLTHRDMGPLARYLGPETPAEELLWQDPIPSVDHALVDDQDVATLKAKILASGLSVSQLVSTAWAAASTFRGSDKRGGANGGRLRLAPQKDWAVNQPEQLAGVLKTLEGIQSEFNAAQSGGKKVSIADLIVLAGNAGVEQAAKNAGQHVTVPFAPGRADASQEQTDVESFSFLEPIADGFRNYQKGHYKVSAESLLVDKAQLLTLTAPEMTVLLGGLRVLNINVGQSKHGVFTDQPGTLTNDFFKNLLDMGVEWKATAGGTDTFEARDRKTGAVKWTGTRVDLVFGSHAQLRAISEVYGSSDAHEKFVKDFVAVWTKVMNLDRFDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: ECNR_CITFR
Sequence: MLKILVIDRCHFTRTGIEALLNHSGRFSSSFLVSGINNLLLAKEHILQWKPHLVIADLNSFISETHSSPPINPFFMSCGVIPLILLQSADRQHAPIAPSQSVAHSVLTKHTTLNTLSHTIQEALQVRPALEIPKNATPLLTPQEEKVLSMWMDGVSNNAIAAALSIHGKTVYTYKRNIRMKLHLGNRFSPFLSLPGKGD
What is the function of this protein?
May serve to repress the entericidin locus in C. freundii.
What are the official names of this protein?
Transcriptional regulatory protein EntR, Entericidin R.
Protein: VKTC9_DABSI
Sequence: HDRPKFCYLPADPGECMA
What is the function of this protein?
Serine protease inhibitor that inhibits chymotrypsin.
What are the official names of this protein?
Kunitz-type serine protease inhibitor C9, BPTI-9, Chymotrypsin inhibitor 9, Chymotrypsin inhibitor C9.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRHO_BUCAP
Sequence: MMSNLCNRISKKELKKKILMNEESRIVVSFYKYFLIKNTKEYRDRIYQNFYKYNVLGRVYVSDEGINAQISIPVKFYFFVKNFLYNSDLELNNLFINKSLSNHKKAFWVLSVKIKKKIVNDGITNPLFNFKKVGIYIKSRQVNMMLSDRNVIFIDMRNSYEYEIGHFPNAIEIKSQTFREQLKKVIQIMHYAKNKKIVMYCTGGIRCEKASAWMHFNGFKYVYHLKNGILGYVHDANKNGLPILFQGSNFVFDNRMSEKISDKIISFCKQCDKPSDRYVNCNFNLCHLLFIQCKDCTIKFKKCCSKYCMQHL
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: GRN2_CYPCA
Sequence: VVYCNARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLCLR
What is the function of this protein?
Granulins have possible cytokine-like activity.  They may play a role in inflammation, wound repair, and tissue remodeling.
What are the official names of this protein?
Granulin-2.
What is the protein family that this protein belongs to?
Belongs to the granulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ST7L_MOUSE
Sequence: MADGDYFAEAARAVGCPHAPVPGLGLGPPLGWKERLKAGLANSGSTLWFLAGLGLLYALRVPLRLCDNVTAVTGFLSSLTPKFYVALTGTSSLISGLIFIFEWWYFHKHGTSFIEQVSISHLRPLMGGTESSISEPGSPANSRESETLRHHHLSECKVWRNPLNLFRGAEYRRYTWVTGKEPLTYYDMNLSAQDHQTFFTCETDFLRPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALRAGEIIYRRSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYADVQAVLAKYDDISLPKSAAICYTAALLKTRTVSDKFSPETAFRKGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPFFIHFTAGLCSSTAMLAFLTHQFPEVMGVFAKAVSMISRTCVEYL
What are the official names of this protein?
Suppressor of tumorigenicity 7 protein-like, ST7-related protein.
What is the protein family that this protein belongs to?
Belongs to the ST7 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YCF2_VITVI
Sequence: MKGHQFKSWIFELREILREIKNSHYFLDSWTQFTSVGSFIHIFFHQERFIKLFDPRIWSILLSRNSQGSTSNRYFTIKGVVLFVVAVLIYRINNRNMVERKNLYLTGLLPIPMNSIGPRNDTLEESFGSSNINRLIVSLLYLPKGKKISESCFLDPKESTWVLPITKKCIMPESNWGSRWWRNWIGKKRDSSCKISNETVAGIEISFKEKDIKYLEFLFVYYMDDPIHKDHDWELFDRLSPRKRRNIINLNSGQLFEILVKHWICYLMSAFREKIPIEVEGFFKQQGAGSTIQSNDIEHVSHLFSRNKWAISLQNCAQFHMWQFRQDLFVSWGKNPHESDFLRNVSRENWIWLDNVWLVNKDRFFSKVRNVSSNIQYDSTRSSFVQVTDSSQLKGSSDQSRDHFDSISNEDSKYHTLINQREIQQLKERSILWDPSFLQTERTEIESDRFPKCLSGYSSMSMSRLFTEREKQMIIHLLPEEIEEFLGNPTRSIRSFFSDRWSELHLGSNPIERSTRDQKLLKKQQDVSFVPSRRSENKEMVNIFKIITYLQNTVSIHPISSDPGCDMVPKDEPDMDSSNKISFLNKNPFFDLFHLFHDRNRGGYTLHHDFESEERFQEMADRFTLSITEPDLVYHKGFAFSIDSYGLDQKQFLNEVFNSRDESNKKSLLVLPPSFYEENESFYRRIRKKWVRISCGNDLEDPKPKIVVFASNNIMEAVNQYILIRNLIQIQYSTYGYIRNVLNRFFLMNRSDRNFEYGIQRDQIGNDTLNHRTIMKYTINQHLSNLKKSQKKWFDPLIFISRTERSMNRDPHAYRYKWSNGSKNFQEHLEHFVSEQKSRFQVVFDRLRINQYSIDWSEVIDKKDLSKSLRFFLSKSLLFLSKLLLFLSNSLPFFFVSFGNIPIHRSEIHIYELKGPNDQLCNQLLESIGLQIIHLKKWKLFLLDDHDTSQKSKFLINGGTISPFLFNKIPKWMIDSFHSRNNRRKSFDNTDSYFSMISHDQDNWLNPVKPFHRSSLISSFYKANRLRFLNNPHRFCFYCNKRFPFYVEKARINNSDFTYGQFLNILFIRKKIFSLCGGKKKHAFLERDTISPIESQVSNIFIPNDFPQSGDETYNLYKSFHFPIRSNPFVRRAIYSIADISGTPLTEGQIVNFERTYCQPLSDMNLSDSEGKNLHQYLNFNSNMGLIHTPCSEKYLPSEKRKKRSLCIKKCVEKGQMYRTFQRDSAFSTLSKWNLFQTYMPWFLTSTGYKYLNLIFLDTFSDLLPILSSSPKFVSIFHDIMYGSDISWRILQKKLCLPQRNLISEISSKCLHNLLLSEEMIHRNNESPLISTHLRSPNVREFLYSILFLLLVAGYLVRTHLLFVSRASSELQTEFEKVKSLMIPSYMIELRKLLDRYPTSELNSFWLKNLFLVALEQLGDSLEEIRGSASGGNMLLGGGPAYGVKSIRSKKKYLNINLIDIIDLISIIPNPINRITFSRNTRCLSHTSKEIYSLIRKRKNVNGDWIDDKIESWVANSDSIDDEEREFLVQFSTLTTEKRIDQILLSLTHSDHLSKNDSGYQMIEQPGAIYLRYLVDIHKKYLMNYEFNTSCLAERRIFLAHYQTITYSQTSCGANSFHFPSHGKPFSLRLALSPSRGILVIGSIGTGRSYLVKYLATNSYVPFITVFLNKFLDNKPKGFLFDDIDIDDSDDIDASDDIDASDDIDASDDIDRDLDTELELLTMMNALTMDMMPEIDRFYITLQFELAKAMSPCIIWIPNIHDLDVNESNYLSLGLLVNYLSRDCERCSTRNILVIASTHIPQKVDPALIAPNKLNTCIKIRRLLIPQQRKHFFTLSYTRGFHLEKKMFHTNGFGSITMGSNARDLVALTNEALSISITQKKSIIDTNAIRSALHRQTWDLRSQVRSVQDHGILFYQIGRAVAQNVLLSNCPIDPISIYMKKKSCNEGDSYLYKWYFELGTSMKKLTILLYLLSCSAGSVAQDLWSLPGPDEKNGITSYGLVENDSDLVHGLLEVEGALVGSSRTEKDCSQFDNDRVTLLLRPEPRNPLDMMQNGSCSIVDQRFLYEKYESEFEEGAGEGALDPQQIEEDLFNHIVWAPRIWRPWGFLFDCIERTNELGFPYWARSFRGKRIIYDEEDELQENDSEFLQSGTMQYQTRDRSSKEQGFFRISQFIWDPADPLFFLFKDQPFVSVFSHREFFADEEMSKGLLTSQTDPPTSIYKRWFIKNTQEKHFELLIHRQRWLRTNSSLSNGSFRSNTPSESYQYLSNLFLSNARLLDQMTKTLLRKRWLFPDEMKIGFM
What is the function of this protein?
Probable ATPase of unknown function.  Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis.
What are the official names of this protein?
Protein Ycf2.
What is the protein family that this protein belongs to?
Belongs to the Ycf2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RS3A_CATRO
Sequence: MAVGKNKRISKGKKGGKKKAADPFAKKDWYDIKAPSVFSVRNVGKTLVTRTQGTKIASEGLEHRVFEISLADLQGDEDHSFRKIRLRAEDIQGKNVLTNFWGMDFTTDKLRSLVRKWQSLIEAHVDVKTTDSYTLRMFCIGFTKKRANQQKRTCYAQSSQIRQIRRKMREIMVNQAQSCDLKDLVQKFIPESIGREIEKATSSIYPLQNVFIRKVKILKAPKFDLGKLMEVHGDYNEDDIGTKLDRPAEEAVAEPTEVIGA
What are the official names of this protein?
40S ribosomal protein S3a, CYC07 protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDC6_MOUSE
Sequence: MPQTRSQTQATIGFPKKKLSNTLKKPNSRDCEVKLRNVQPVPTTPCVDVKLLPLSPRKRLGDDNLCNTPRLSPCSPPKLGKKENGPPRSHTWKGCRLVFDDEPTFKASPPKEQDRVRQHQIRSSSAQRSPESKADPEQKCPPEKESVCIRLFKQEGTCYQQAKLVLNTAVPDRLPAREQEMGVIRNFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQDFKKEVKGFKSILLNCMSLRSAQAVFPAIAQEIGREELCRPAGKDLMRKLEKHLTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEARENCKPQLLNFPPYTRNQIAAILQDRLSQVSKDQVLDSAAIQFCARKVSAVSGDIRKALDVCRRAIEIVESDVRSQTVLKPLSECKSPSESPVPKRVGLAHISQVISEVDGNRVTLSQENTQDSLPLQQKILVCSLLLLTRRLKIKEVTLGKLYEAYSSICRKQQVTAVDQSECLSLSGLLESRGLVGLKKNKESRLTKVSLKIEEKEIEHVLNGKAFTGNILAAGLP
What is the function of this protein?
Involved in the initiation of DNA replication.  Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
What are the official names of this protein?
Cell division control protein 6 homolog, CDC6-related protein, p62(cdc6).
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells.
Protein: ANO4_BOVIN
Sequence: METSSSGITNGRTRVFHPVAKDVNILFDELEAVNSPCKDDDSLLHPGNLTSTSDDASRLEAGGETVPEKNKLNGLYFRDGKCRIDYILVYRKSNPQMEKREVFERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAVNHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVITLDHCQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFADKCSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKNGKAHHNEWP
What is the function of this protein?
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity).  Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity).
What are the official names of this protein?
Anoctamin-4, Transmembrane protein 16D.
What is the protein family that this protein belongs to?
Belongs to the anoctamin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization.
Protein: PDC2_SCHPO
Sequence: MTKDAESTMTVGTYLAQRLVEIGIKNHFVVPGDYNLRLLDFLEYYPGLSEIGCCNELNCAFAAEGYARSNGIACAVVTYSVGALTAFDGIGGAYAENLPVILVSGSPNTNDLSSGHLLHHTLGTHDFEYQMEIAKKLTCAAVAIKRAEDAPVMIDHAIRQAILQHKPVYIEIPTNMANQPCPVPGPISAVISPEISDKESLEKATDIAAELISKKEKPILLAGPKLRAAGAESAFVKLAEALNCAAFIMPAAKGFYSEEHKNYAGVYWGEVSSSETTKAVYESSDLVIGAGVLFNDYSTVGWRAAPNPNILLNSDYTSVSIPGYVFSRVYMAEFLELLAKKVSKKPATLEAYNKARPQTVVPKAAEPKAALNRVEVMRQIQGLVDSNTTLYAETGDSWFNGLQMKLPAGAKFEVEMQWGHIGWSVPSAMGYAVAAPERRTIVMVGDGSFQLTGQEISQMIRHKLPVLIFLLNNRGYTIEIQIHDGPYNRIQNWDFAAFCESLNGETGKAKGLHAKTGEELTSAIKVALQNKEGPTLIECAIDTDDCTQELVDWGKAVRSANARPPTADN
What are the official names of this protein?
Probable pyruvate decarboxylase C1F8.07c.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: MMPL8_MYCTO
Sequence: MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVIAFWVALAGLLAPTVPSLDAISQRHPVAILPSDAPVLVSTRQMTAAFREAGLQSVAVVVLSDAKGLGAADERSYKELVDALRRDTRDVVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARVADIVEHQVAGSTLTANLTGPAATVADLNLTGQRDRSRIEFAITILLLVILLIIYGNPITMVLPLITIGMSVVVAQRLVAIAGLAGLGIANQSIIFMSGMMVGAGTDYAVFLISRYHDYLRQGADSDQAVKKALTSIGKVIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAAVTLLPALMVLTGRRGWIAPRRDLTRRFWRSSGVHIVRRPKTHLLASALVLVILAGCAGLARYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRTPKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKLDEGSKQIAVHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGGLIDALAYLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTEWASPVLGALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQLQATRAVQTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGSRQLAEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGFYIPPELLSYATGESVKAETMPSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQTDLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGLPVVLKDTRDYSDHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIGVIVFQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIRTVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVRTVTVPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEEEEQSPPDDDDLIGLWLHDGLRL
What is the function of this protein?
Required for the biosynthesis and the transport across the inner membrane of sulfolipid-1 (SL-1), which is a major cell wall lipid of pathogenic mycobacteria.  Could also transport SL1278 (2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate), which is the precursor of SL-1.
What are the official names of this protein?
Sulfolipid-1 exporter MmpL8.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.