PharMolix/UniProtQA huggingface dataset:
Protein: BLM_HUMAN
Sequence: MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTALKKLEFSSSPDSLSTINDWDDMDDFDTSETSKSFVTPPQSHFVRVSTAQKSKKGKRNFFKAQLYTTNTVKTDLPPPSSESEQIDLTEEQKDDSEWLSSDVICIDDGPIAEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHSTEKVPCIEFDDDDYDTDFVPPSPEEIISASSSSSKCLSTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIGSSSASHTSQATSGANSKLGIMAPPKPINRPFLKPSYAFS
What is the function of this protein?
ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030).  Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288).  Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134).  Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030).  Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030).  Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (PubMed:20639533, PubMed:24257077, PubMed:25901030).  Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity).
What are the official names of this protein?
RecQ-like DNA helicase BLM, Bloom syndrome protein, DNA helicase, RecQ-like type 2, RecQ2, RecQ protein-like 3.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner.
Protein: RL29_VIBPA
Sequence: MKAQDLREKSVEELNAELMNLLREQFNLRMQAATGQLQQTHTLKAVRRDIARVKTVLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: MDTJ_SALA4
Sequence: MFYWILLALAIATEITGTLSMKWASVGNGNAGFILMLVMITLSYIFLSFAVKKIALGVAYALWEGIGILFITIFSVLLFDEALSTMKIAGLLTLVAGIVLIKSGTRKPGKPVKEAARATI
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtJ.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PALY_PERAE
Sequence: MESMDKGTDSYGVTTGFGATSHRRTKQGGALHKELIRFLNAGIFGTNGESGHTLAPSATRAAMLVRINTLLQGYSGIRFEILEAITSLLNHSITPCLPLRGTITASGDLVPLSYIAGMLTGRPNSKGDWPDGKEIDAGEAFRLAGIPSGFFELQPKEGLALVNGTAVGSGLASMVLFEANVLSVLSEVISAIFCEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSSYMKVAKKLHELDPLQKPKQDPYAALRTSPQWLGPQIEVIRNATLSIEREINSVNDNPLIDVSRNKALHGRNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGAEIAMAAYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTAEAVEILKLMSSTFLVGLCQAIDLRHLEENLKSTVKNTVSQVAKRVLTIGVNGELHPSRFCEKDLIKVVDGEHLFAYIDDPCSCTYPLMQKLRQVLVEHALINGEKEKDSSTSIFQKIGAFEEELKTHLPKEVESARIELERGNSAIPNRIKECRSYPLYKFVREELKTSLLTGEKVRSPGEEFDKVFSAICQGKVIDPLLECLREWNGAPIPIC
What is the function of this protein?
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
What are the official names of this protein?
Phenylalanine ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CADD_LEPIC
Sequence: MALTFQEILDRIRIIDRDVTELNRLKSRLPADRPYSSSLQISFDKQINELLNERVGLMELEVLDPPSWILGVPTTGISQETPVPLKGLFPSGDLSKEKPDDQDVINFLRELPKTEIHLHLEACVNKDTMKRLMAKNGINVTDEEFEAKFNFKDLNSFIQVFFFIQSLVKEPSDFSFFIESLAEYMRANNILYTEVFFAPSKFIQNGLDFEEMIDFLVNRIREEKENDGIVIRLLVDVSRSFGPENAMKNLDRVLKLRHPEVIGIGLGGAELMGPARDYQGVFQKAREAGLRVVAHSGEDDGPWAIWEAVELLKAERIGHGTSAIQDPELVKYLRENHIPIEICVTSNVFTGKYVRKEQNHPVRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFSLDEIVDLIRQGVFASFHPNKESLWAEMEKNIHLVKTRYGLKR
What is the function of this protein?
Deaminates cAMP into cIMP, thereby repressing cAMP dependent metabolism or genes.
What are the official names of this protein?
Cyclic adenylate deaminase, CadD, cAMP deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Protein: P5CR_PASMU
Sequence: MQAKSICFIGGGNMAQAIIFGLLKQGYPANQITVSDPNAAKRQCLAEKGVNTVEASQTDTQDAVETSEVLLLAVKPQMIAAVCQGLSAVDFSQKLVISIAAGVSVTKLQSRLPTAKQIVRVMPNTPALVAEGMSGLFAQNSLKPEYKQFTQDLLNAVGKTCWVTQEADMHTITAGSGSSPAYFFLFMEAMQQALCQMNMDEDTARLLVQQSALGAAKMVIENPDLPIATLRENVTSKGGTTAAALQVLNQQQLQHIVQQAMQACVERSQQMEKLF
What is the function of this protein?
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase, P5C reductase, P5CR, PCA reductase.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_GRABC
Sequence: MSAKHVLISGVVQGVGYRAWLRSRAEALGLSGWVRNRLDGRVEALIAGDIAAVEELIRACRTGPSAARVDRIEEHLDTDPITPGFEQYPTV
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: TBP_PYRHO
Sequence: MVDTSNVKLRIENIVASVDLFAQLDLEKVLDICPNSKYNPEEFPGIICRFDDPKVALLIFSSGKLVVTGAKSIQDIERAVAKLIQKLKGIGVKFKRAPLIDVQNMVFSGDIGREFNLDNVALTLPNCEYEPEQFPGVIYRVKEPRAVILLFSSGKIVCSGAKSEADAWEAVRKLLRELEKYGLIEEEEEEL
What is the function of this protein?
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
What are the official names of this protein?
TATA-box-binding protein, Box A-binding protein, BAP, TATA sequence-binding protein, TBP, TATA-box factor.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
Protein: ACTC_BIOGL
Sequence: MCDEDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMQTASTSSSLEKSYELPDGQVITIGNERFRCPEATFQPSFLGMEAAGIHETTYNSIMKCDVDIRKDLYANTVLSGGSTMFPGIADRMQKEITALAPPTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SYS_ALKCK
Sequence: MLDVKKLRSDFEGVKAQLERRNGTIEGLERFSQLDASRRTMIQEVEELKSKRNDVSEQIAALKRDKKDANSLIAEMKQVSERIKEQDEQLRSIETELEALLLTIPNIPQEDVPYGESEEDNREERKWGDVPDFSFEPRPHWELGTALDILDFERAAKVTGSRFTVYKGLGARLERALINFMMDMHATEHDYTEVLPPYIVNRASMIGTGQLPKFEEDVFKISEEDYFLIPTAEVPVTNLHRGEVLQGEQLPIAYNAYSTNFRSEAGSAGRDTRGLIRQHQFNKVELVRFSLPEDSNNQLEIMTTHAENVLKRLGLPYRVVTLCTGDLTFASTKTYDLEVWMPSANTYREISSCSNIGDFQARRANIKFRRDPKSKPEYVHTLNGSGVAVGRTVAAILENYQQEDGSIVIPEALRPYMGNVNILS
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OMP2B_BRUSI
Sequence: MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKGARFALMFNTNSETELGTLKTFTELRFNYAANNSGVDGKYGNETSSGTVMEFAYIQLGGLRVGIDESEFHTFTGYLGDVINDDVISAGSYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTGTTNYHIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWAAKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTVTPEVSYTKFGGEWKNTVAEDNAWGGIVRFQRSF
What is the function of this protein?
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
What are the official names of this protein?
Porin Omp2b.
What is the protein family that this protein belongs to?
Belongs to the alphaproteobacteria porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: BFRA_THEMA
Sequence: MFKPNYHFFPITGWMNDPNGLIFWKGKYHMFYQYNPRKPEWGNICWGHAVSDDLVHWRHLPVALYPDDETHGVFSGSAVEKDGKMFLVYTYYRDPTHNKGEKETQCVAMSENGLDFVKYDGNPVISKPPEEGTHAFRDPKVNRSNGEWRMVLGSGKDEKIGRVLLYTSDDLFHWKYEGVIFEDETTKEIECPDLVRIGEKDILIYSITSTNSVLFSMGELKEGKLNVEKRGLLDHGTDFYAAQTFFGTDRVVVIGWLQSWLRTGLYPTKREGWNGVMSLPRELYVENNELKVKPVDELLALRKRKVFETAKSGTFLLDVKENSYEIVCEFSGEIELRMGNESEEVVITKSRDELIVDTTRSGVSGGEVRKSTVEDEATNRIRAFLDSCSVEFFFNDSIAFSFRIHPENVYNILSVKSNQVKLEVFELENIWL
What is the function of this protein?
Hydrolysis of sucrose, raffinose, inulin and levan.  Specific for the fructose moiety and the beta-anomeric configuration of the glycosidic linkages of its substrates.  The enzyme released fructose from sucrose and raffinose, and the fructose polymer inulin is hydrolyzed quantitatively in an exo-type fashion.
What are the official names of this protein?
Beta-fructosidase, Invertase, Sucrase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 32 family.
Protein: ABC8A_MOUSE
Sequence: MVKREINVCQQTWALLCKNLLRKKRLKRDTFLEFLYTALILLSLILFLQLHEVYDFSSLPDVDLGRIDSFNDSTFMIVYTPITPTTQRIMDRVSLVSYMTGRKILASPNEENMTELISMRFSDVVGVIFTNAYSYNLKFIKGARIPTIKEHQDHTAHCHSYGEIIYCGLSEFWRDGFVALQAAINAAIIEVTTNHSVMEEMMSLTGKYIKIDSFVGQEGTTTDCFLFFCIIRFSPLTYYISAGVTRERKKMKGLMAVMGLRDSAFWLSWGLLYGVIVFVVTLLSTTIVKLVQFVFLTGFMVIFSLFFFYGLSLISLSFLMSVLLKKSFLTDLVVFLLTVSCGSLGFTALYRYLPVSLEWLLSLLSPFAFMLGMVQLLRLDYDVNSNADPMGNPNEVIGTIFMLFFDGVFYLLLTFYFEKVLPSKSFHDKTYWHACKSHFFLIDYSFYIRTALDNETDYEFSDDSFEPVSMEFHGKEAIRIRNLTKDYIQKSKRTEALKDLTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHNNKLSEMTDLENISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQAHEVDNEVQRVLLELDMKNTQNILVQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNFLKERRADRVVLFSTQFMDEADILADRKVFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAESEGKLSYILPLERTNKFPDLYRDLERSPDLGIENYGVSITTLTEVFLKLEGKSSIDQSDIGMTEDVQAGGARSPERFAEVEQLVSLLNGRCKMKGGMALWWQQLCAVTRLRFLKLKHERKSIVILILVLGIGLLHILSANIYRMVRQSDYCWELAPHMYFLTPGQQPQPPLTNLLIVNKTGAKIDDFIHSLEQQNIALEVDAFGTRNGTEDSQYNGAIILSGDEKNYNFTLACNTKRLNCFPVLVDIVSNGLLGLFAPSAHIQTDRSTFPEENDHRKFDYLAYFFLWVLLMACVPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFGQALFEVPVYCALILSIFIAFYASAPPESKFTVGDLFIQILYVGGYAMSVIFMTYVISFIYRKGRKNSGLWSLCFYIVSFFSMCFMLIDYFRDISLFVLIALVPPATLGGCTLLHFENREFSEIIFEPEREYSYLFFLAPLLHFAIFVVILRCMERKFGMKTMRTDPVFRISPRSDRVFNNPEDPDGEDEDVSQERVWTANALTSADFQEKPAIIASCLRKEYKGKKKCFVLKSKKKIATRNISFCVRKGEVVGLLGHNGAGKSTSIKMITGETKPSAGQVLLKGSSTGDTPGFLGYCPQENALWLNLTVREHLEIFAAIKGMRKSDANVAIERLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIQATFSNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKEYLLEMKVKTPSQVEPLNTEIMRLFPQAARQERYSSLMVYKLPREDVQPLSQAFFKLETVKQSFDLEEYSLSQSTLEQVFLELSKEQELDGFEEELDPSVKWKLLPQEEA
What is the function of this protein?
Mediates cholesterol and taurocholate efflux.  Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels.
What are the official names of this protein?
ABC-type organic anion transporter ABCA8A, ATP-binding cassette sub-family A member 8A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=Predominantly expressed on the sinusoidal plasma membrane.
Protein: NTPP_RHOPS
Sequence: MTLWLGPQPLVLASQSRARQALLTNAGIPFEAIPAKLDERGIARVSGLSAPGDIAALLAQEKAAFVSNHHPGRLVLGADQTLALGAREFNKPADRNEAAKQLRELAGRRHELHSAIAVVRNGITLFAEVVIARMTMRPLSDEEIAVYLDEVGDTATCSVGGYQVEGLGVHLFDGIHGDHSTILGLPLLPLLGFLRSQKLLTL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_RUTMC
Sequence: MAYSFTEKKRIRNNFGSRESILTEPDLLAIQIDSFNSFIQKDSKTKQDIGLHAVFQSVFPITAVNGYAQIEYVDYELQEPKFNVEECKLRGVTFASTLRVKLSLVLFDKNGSTLKKKRKIKQIIEEDIYLGQLPLMTETGTFVINGTERVVVSQLHRSPGVIFEHDKGKTHSSGKILFSSRIIPYRGSWLDFEYDHHEHLYVRIDRRRKLPVTTLLRAMGLSSEGILETFFEKTTIKLKAKSCDLNMVPIRLQRTIAEFDIVANQDVIVEKGRRITAKHVKLLKKVGIKSINVPLEYLLDKVISADIFDKDTGEILISANTIILEEVLELLNINKIKKIEILYINASETGAYISDTLRLDETQTEIEARMSIYHVMRPGEPATEDAVNLLFNNLFFKNDRYDLSKVGRMKLNRRLGIGSETGEHVLTNDDIISVIKLLINIKDGNDSVDDVDTLANRRVRAIGEMIENQFRVGLVRVEKVVREGLNLAETDELTPQDLINSKPVSAAVREFFGSSQLSQFMDQVNPLSGVTHKRRISALGPGGLTRERAGFEVRDVHPSHYGRLCPIETPEGPNIGLINTLAVYAKTNSYGFLETPYQVVKNGKVTKEVVYVSAIDEITHTIAQVNAIVNDKGKLMSDLISCRHKNEFVLVNSSKVTLIDIDSKQIASVAASLIPFLEHDDANRALMGSNMQRQAVPVLKAEKPLVGTGIERVVATDSRVCVTAKHSGVVEAVDASRIVIRVDSKKTKASELGVDIYNLTKYSRSNQNTCINQKPLVKTGDKISAADVLADGPSTDMGELALGQNMKIAFMPWNGYNFEDSILISEKVIQEDRYTTIHIEELTAYSRDTKLGPEEITADIPNVSELALAKLDEVGVVYVGARVKGGDILVGKVTPKSETVLSPEEKLLRAIFGEKANNVKDSSLRVGASKSGVVIDVQIFTRDRVEKDDRALSIDAERLERIKKDIDDEFGIIDGDIFRRVRLKLSGNMLSKVAGDIKAGEKLSAKLMKKLDNKDISKLKVEDAAVNKEVAALIKQAKAKQIEFKKFFEEEKAKINEGAELPPGVMKMVKVYVATSKTLQVGDKMAGRHGNKGVISRVSPVEDMPYLVDGSTIDVVLNPLGVPSRMNVGQVLEVHLGYAAKGLGYKITAMLDEKRTDMVKQIRDFLDEVYNSYGKQENLASFSDEEIIELASNLREGVPMATPVFDGIKEKDIKSLLKLADLPESGQEQLYDGRTGEPFDRHVTVGYMHMLKLNHLVNDKMHARSTGPYSLVTQQPLSGKAQFGGQRFGEMEVWALEAYGAAHTLREMLTVKSDDVGGRAKMYKSIVDGKNLTESIMPESFNVLVKEIRSLGIDVELEQH
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: GLPE_SALA4
Sequence: MEQFECITVEEAYQKLRQGAAVLVDIRDPQSYAMGHAPQAFHLTNDTLGAFMRKHGFDTAVMVMCYHGNSSKGAAQYLLQQGYDAVYSIDGGFEAWHRRFPANVANGA
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PV21_POMMA
Sequence: MSQLRWWVVSQVLLLIAICSLDHSEGARVCPKIVPGLDKLRVGVDITKLDLLPLFDLGDNGFRSAVADYTCDRGQTAVVDGESFDVPDQVDSVVIESSGQQTSSVTTIKSESQISQALSISAGISVETAKAGFSSSASYAEMQEAITKYGRTVSQMSAVYTTCSANLSPNLLLGQNPLQTLSRLPSDFTADTQGYYDFIKTYGTHYFNKGKLGGMFLFTSETDMSYFQNKNSQQIEATVKATFASILSTETGGSSDESKEVIEFKESSLITSKFFGGQTNLAADGLTKWQPTIAKLPYFMSGTLSTISSLIADTTKRASMELAVKNYLLKAKVANLDRLTYIRLNSWSVGHNELRDLSAQLQNLKTKTIFSDADEKLLQSIEDQVSVPAWFSDRTTFCFRSTAVGSADQCNGQSTNTLCAEPNRYTQQYMDKTYLGDTGCRLVWKISTTESTDWFKSVKVNFRWYPTWSPCACGPVGTPFTISAPANSWTQDYLDVTNPKFGECMLQWMIEVPPTATLWAKNLEFCIDFTCGKKKQCVDANQWTEPYLDISAHEACGMSWALIAK
What is the function of this protein?
The egg defensive protein perivitellin-2 is a pore-forming two-subunit glycoprotein that affects both the nervous and digestive systems of mammals (PubMed:32231667, PubMed:32446810).  In addition, it is a source of both structural and energetic molecules during embryonic development (By similarity).  The tachylectin subunit (31 kDa) binds target membranes while the MACPF subunit (67 kDa) disrupts lipid bilayers forming large pores (inner diameter of about 5. 6 nm) altering the plasma membrance conductance (PubMed:32446810).  Both in vivo and in vitro, the protein shows wide pH range stability and is resistant to enzymatic proteolysis from gastrointestinal environments (PubMed:32231667).  It is cytotoxic to both epithelial and immune cells from the digestive system of mammals (PubMed:32231667).  It induces enterocyte death by a lytic mechanism and disrupts enterocyte monolayers in a dose-dependent manner (PubMed:32231667).  After oral administration to mice, it binds enterocytes and induces large dose-dependent morphological changes on their small intestine mucosa, reducing the absorptive surface (PubMed:32231667).  Additionally, it is detected in the Peyer's patches where it activates lymphoid follicles and triggers apoptosis (PubMed:32231667).  The toxin can also traverse the intestinal barrier and induce oral adaptive immunity with evidence of circulating antibody response (PubMed:32231667).  The toxin also shows hemagglutination properties thanks to the tachylectin subunit, but has no hemolytic activity (PubMed:32446810).  In addition to enterotoxin activity, the toxin also acts as a neurotoxin, since an intraperitoneal injection can induce paralysis of the mice rear limbs, followed by death (PubMed:32446810).
What are the official names of this protein?
Perivitellin-2 67 kDa subunit, PmPV2 67 kDa subunit, PmPV2-67, PV2 MACPF 'A' toxic subunit, Pma_3499_0.31, Pore forming toxin, PFT.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: MURD_LEUMM
Sequence: MQATDFKNKKVMVFGWARSGKAAAQLLTKLGSKVTVVNGGEFDAQDATYRSLLAADVTLIGTDNAETLDSTYDYLIKNPGINYDHPLVQKAEKLNIPILTEVEIALSTFNGRLIAVTGSNGKTTTTSLIRDMLKADGQNVITAGNIGVPVSEVVFDLTREDTLLLELSSFQLLGLPDIQPDIALVTNIFSNHLDYHKTRANYVAAKFRITRHQNANQYLVLNADGQDTEKFKNETEAQVLEFSRTKQHFPVAFSNGNLTLTDEIVMPTKDIKLVGPHNQENILAAVTVANLAGVSKPAIREVLKTFSGVAHRLQYLFTAGDVKYYNDSKATDIEATQTALDSFDCPTIWIGGGLERGDDLERLLPNLKNVKAVIAVGETQQKIVTLAREAGKPVIAVTDVEHAAPVAVQLASPGDVVLLSPAQASWDQYSSFEERGDNFVASLKETLNS
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_PECCP
Sequence: MSNIIKQIEDEQMKQDVPAFRPGDTVEVKVWVVEGSKKRLQAFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVVDSIAVKRRGAVRKAKLYYLRERTGKSARIKERLN
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: KL41A_DANRE
Sequence: MEPMSVKEDLRLFQSTLLQDGLKELLKENKFVDCILKVGDRSLPCHRLIMAACSPYFRELYFTEDGTEKKDANKEVVLENVDPNIMDMIVNYLYSADIDITDDNVQDVFAVANKFQIPSVFTVCVNYLQNKLSLGNCLAIFRMGLVLNCPRLAVSARDFIAEHFETLSKDEEFLEFNAPEFFAIIGCDALNVEKEELVFELLMKWVRKNKENRAKALGDAFEHIRFRLLPEKYLKEKVEKDDIIKADPELIKKLKVIKDAFAGKLPQIKEGEKEGEGENELPGFLNDSQRLGMFNRDLILMINDTAAVAYDANENECFLAAMAEQIPRNHVSITSKKNLLYVAGGLFVDEENKDSPLQCYFYQMDPHSPNWIALPPMPSPRCLFAMGEFENLLFAVAGKDLQSNESLDSVLCYDVDKMKWLETKKLPLRIHGHSVISQNGLVYCIGGKTDENKTINKMFAYNHKKSEWKELAAMKTPRSMFGATVHKGKIVVVGGVNEDGLLSSCEAYDFGTNKWEVFAEFAQERSSVNVLSVDGVLYAVAGFTIKENEDKQCVPSEITDIWQYEEDKKQWSGMIGEMRYASGASCVSMRLNVAKMPKL
What is the function of this protein?
Involved in skeletal muscle development and differentiation.
What are the official names of this protein?
Kelch-like protein 41a, Kelch repeat and BTB domain-containing protein 10b.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Sarcoplasmic reticulum membrane. Endoplasmic reticulum membrane.
Protein: CRCB2_STAHJ
Sequence: MQYLFVFIGGLFGALLRYVLSTLNVDSGLPLGTLIANIVGAFLMGYLSSLSIHFFKNNPLIKKGVTTGLLGALTTFSTFQFELVTMSQNNSIALLFIYGLTSYIGGILFCWFGVKLGGQPT
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SPI8_SOLTU
Sequence: LPSDATPVLDVTGKELDPRLSYRIISIGRXALGGXVYLGKSP
What is the function of this protein?
Potent inhibitor of animal pancreatic trypsin (serine protease).
What are the official names of this protein?
Serine protease inhibitor 8, PKI-1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.
Protein: HEXA_CAEBR
Sequence: MRLIVLSLLFTSTLAWFYGRDEPDRWSVGGVWPLPQKIIYGSKNRTLTYDKIGIDLGDKKDCDVLLAMADNYMNKWLFPYPVEMKTGGTEDFIITVTVKEECPGGPPVHGASEEYLLRVSVSEAVINAQTVWGALRAMETLSHLVFYDQKSQEYQIRTAEIFDKPRFPVRGIMIDSSRHFLSLNVIKRQLEIMSMNKLNVLHWHLVDSESFPYTSQKFPELHGVGAYSPRHVYSREDISEVIAFARLRGIRVIPEFDLPGHTSSWKGRKGFLTECFDEKGEETFLPNLVDPMNDANFDFLAEFLEEVTETFPDQFLHLGGDEVSDYIVECWVRNKKIRKFMDEKGFGNNTVLLENYFFEKLFSIVEKLKLKRKPIFWQEVFDNNIPDPNSIIHIWKGNTHEEIYEQVKNITSKNFPVIVSACWYLNYIKYGADWRDEIRGTAPSNSRYYYCDPTSFNGTDTQKNLVLGGIAAIWGELVDNTNIEARLWPRASAAAERLWSPAEKTQKAENAWPRMHELRCRLVSRGYRIQPNNNPDYCPFEFDEPPATKSEL
What is the function of this protein?
Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines.  Degrades chitotriose (By similarity).
What are the official names of this protein?
Beta-hexosaminidase A, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 20 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: TRPC_STRGC
Sequence: MSKEFLPTILEQKEQEVEAMSYEELQPLRSTYSLYEYLKSQSQELQLIAEVKKASPSLGDINLAVDIVEQARTYERCGAAMISVLTDEIFFKGHLDYLREISSQVSIPTLNKDFIIDEKQIVRARNAGATIILLIVAALSEKRLQELYDFATGLGLEVLVETHNLAELETAHRIGARIIGVNNRNLVTFETDINTSLQLSAHFKDDRVYVSESAIFSKEDAEQVAPYFHAILVGTALMQAEDVAEKIKELKIDKG
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.