Protein: ATM_CRYNB
Sequence: MDSVSGLHAALSLCASDSAKDRARAHALLPPIFANAQNLRVFQAAAATHGGAPWLALFHCLFRAVALEKRAVLRGSSNAQAAARLAHAIRIVRLVAEQAVHLIARKPLIALVAHMRHQLVLPPRIFAPALLDYSKALSTLLVYPPHVESLDRHTWLALMSMCFAAILGDDHVSDDQMDDADMLGVAAELERLDAENVPPHRPPVTLNTSSLVQIIPALLCSTVSPIVPPTMKSGDTLTAGQKVGLGIVLKIRRFFTMYPHVTIYHLHLLTALNTVLSDMELNCRDLFLLGSVKIFPHLVTLWAAPERDRDRRIPEQIAIAIHRILPHLAHSAELQRAQDVTENVERLMEMLAKESTMSRGIEPLDLGTFPSTATPSRQSTPSKRRKLENPLASLISAVGMGRPESRLIALQTLVFVIDRHWSKLAKDIQSDIRRTLVSLLTDDNETLQSWAYIALSTIILSSYTAGANENNDDDQSHNGQSQDDWKQVWSFALRKCHLPGSSRSASHAAAVLLQFDKVDSPSTIRGIQTMLTTIAVQGPPTAHDSVCALYSIALEAARSDIQLYSLNLEEQVLSWLEKTFAREKFERDKMDQRLDQATPGDILRLFSAVSRIQYHVPLAEPVTKEFLPDSAVVSYALERAKTQPIRDFLLYHTCPTPPPPPPPLDDSHTTPLLAASENHSTFLGGRPRRLSELLLSILNATTAQWETKPVISSGERPRRCVDLVALGLAFQGLLQLDGYIPHAACINAAIRLLHLLKPSLTSSDLSIPSLDLVWRGLRCLADVPLVKEEEEEEEEEDWPILVKPDVQSGIRQDLLPPTMYDTPPQEEEAESSDPPKRFTQYPPTFPSTLLPTPTAITPSSLSTFQSQSNSASLVHAIWRLPDVSAALQGLFSVCLQVITRSSSSTSSGQPTQLSHDDDDDGEDDDDDFAVASGETTSAPLPEKAAELRASTSLLRSAVAFRLQGVMLVSAGAAGGAQSKAYKDTQLVNSFLQADGLRAVEIGWAICEAMQKGWLRLGIDAVDLVVASLGNMLNSYGYARDERLLQLCLEFLKCSAPVWMGNDHSNDDDLKDEAMRLVCYIATKITAGSITSWRVRLAMLRFIEAFLHYDSASKLWADCMVQEEAEEEEQDVSMEDENHLFHYIAQSLSDPDMRVRARAATTAASALYRPSIHPSEHPIIYDQVSNSQAGDPTFAEHYLSYVLWKLNCCIASAKQRQTVIFDLYEAAIGGTEYSDHLQAGLNAVARRLGLPSITALYLPYAPTTTISHDTSRSSAIAFVLNTTHRLFGLSNRSAFFTACLEHAGAYMLYCGKIGLFTSACDAAGVLPEDLALQLSVAAAAMAMVLPLSNDKATNVSMNKCKAEALALLSSFPGISGPDAAEKFLHSYANGVAAHLWELMDLESSVDEIVAWFDKTEKESAAGIAFAQMMAHDNAKTGRVKAINPAASFQSIHNVCRFLEKNYSSISLHAFTFAAILRLTSLINNAFLVSEQRRYLRALAMLLSVHQGTLQRPLIWEAFLTETITLLLQPDICRTVLSMVMWAFDWLESLSSTPSKLVNIFCQLGEIRIELGGSGTPGSQPNQMGDALEDWIVKMSPKWFKSQISQEAFERAVALWPDSLRSRLSVHASPLSLRDLDDLSQNDAVHNAGQLCKHFLHLADADHGQDVVSVFVDSTFWSLKDKISSVWDKEGINAFQDLLYLCNGEVRAPSLNFYGQDTFSKALNATTGEHKKTEAMNALYHAMCKTMVQLLHDRRPQIRSAAYRCLQRMKPILTGKDLKELPADVSDVVPILVPIPIGSVRQSQAMKLDGVINNATWNKKAEHFATWSLELSRLLCKTASQHDKFFLSFEPLLSTPLLPLHHFLGHFVHAALVCSRSMSSERSKAISEHFETVLQNPFASIEAVRSIVNIVLQLRRYEHPFTSGMLGYNAWLSVNFVDLSKAAVKCGLYVSALLFLELANDQGESLDLAEPRVRQIMYDIYSNVEDPDGFYGIHNKDIRDSLRRRLEHEGLSWQALGWAGAVYNVDGNDSRSAIPVLHHLHDIGLSRLASVVATETRTSGSVPLDDPFFADLSWRTGDWNLPIGRESSATSSGLLYSALSAVHRSKSYESASKIVDKAVRAEMTRLGGLQKEMLTSIQSTVTNLLCLRELNRWLDPQLQQGMQEAIDRGTLRDLQDINDKFEFASAERIIATRLSVFDSVKQRESQDMIGDALTPKMELVTKAESTCHIKLSRLALKSNNLQAAINSLTALQKLQTDVGVIDEAQDVFCEVLWKQGEHTLAIQLLEDLLLREKEKKSKGQRIPALEGRLAHWASEARLKAANEIFGMFSNVTKSIKRSTADVSEHAEIFYQFACFADKQYVSQSSSADVKQLKEYSKLRASQALRLSARQSRARESDQKDSAVREAERDEEKLKKFEMQQKQYLNAALQFYAEAVSMSDNFNDCITRLVTLWLENDENEESNVTFSRAAHKVPSYKFIFLGPQLAARLHRPESPTIFNSTLNGLMFRMSQDHPYHTLYHVIPLLWEHKQPQSTNSSMLGRKSAADDIMRRLASSASNRLAVGAAKSMKRFVAIAMEWTSFFEKDKRLEYKLPSDSPLRKAPRDIPVATSTPSIDVTCQYKDIATFDHFSEWYTRAGGLSRPKVMTCFDSNGQKYTQLFKKDDGFRQDAVMEQIFVLVNDLLNRNRQTRSRKLRYRTYGVLALPEATGVIEFVVGTKPLIKYLPPAHEKYHPKDITSHDFLKAMQEVQSVKNNDEKIIQVWTKLKKRFRPVMRHLFTEKYRDPMAWFSMRLTYARSLAVTSIVGWVLEIGDRHCSNILMDECTGELVHIDFGIAFGAGRILPIPELVPFRLTDDLVDALGVTGVNGTFRQCSQLVLQTLIDSSDVILTILEVFKQDPLHTWMVDDKMKKAQDGNHKMYPERGQEKADRIMRETRENLSKELSVQYRVNQLIQEARDVNNLATIFRGWHSWL
What is the function of this protein?
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor.  Recognizes the substrate consensus sequence [ST]-Q.  Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism.  Required for the control of telomere length and genome stability (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase TEL1, ATM homolog, DNA-damage checkpoint kinase TEL1, Telomere length regulation protein 1.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. ATM subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere. Note=Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks.