PharMolix/UniProtQA huggingface dataset:
Protein: BCCP_CYACA
Sequence: MLHSSIYWKNLINTFESGCFSIAEVKFIFSNIHIYKNICNPYKNYQLPELARNLQSSKKLDNAILKQDKKNIIDILSPISGIFYSSSKPGASPFVAVGSVVSKGQTLCIIEAMKTMNEIESDSIGKIHQICARNGDFVTKNQVLMKIILEQS
What is the function of this protein?
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
What are the official names of this protein?
Biotin carboxyl carrier protein of acetyl-CoA carboxylase, BCCP.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL27_THIDA
Sequence: MAHKKAGGSSRNGRDSESKRLGVKRFGGQVVLAGNILVRQRGTQFHPGDNVGIGKDHTLFAKTDGTVKFEIKGAARRKVVRIEPLAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RS7_DECAR
Sequence: MPRRREVPKRDILPDPKFGNVEVSKFVNAIMQSGKKSVAERIVYGAFDIITTKGGKDPLEVFSAAMSNVKPMVEVKSRRVGGANYQVPVEVRPARRAALAMRWLRESARKRSEKSMGQRLAAEMLEAAENRGGAVKKRDEVHRMAEANKAFAHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ATPA2_BURP0
Sequence: MTPTPDAPAAADADAATGAGWLARRRGALARVALAPVAQAIGRVERVADGIAFVSGLEDTMLNEVLRFEGGVTGFAHTLDEDLISVVLLDPDAGVRAQTAVARTGAVLEVPAGPQLLGRVVDPLGRPLDGGAPLDAAHTLPIERAAPAIIERDLVSEPLDTGVLIVDALFTIGRGQRELIIGDRATGKTSLAIDAIVNQRHSDVICVYVAIGQRASAVRRVIDAVRRYGAPERCVFVVAPAACAPGLQWIAPFAGFSIAEYFRDRGQHALVVVDDLTKHAATHRELALLTREPPGREAYPGDIFYVHARLLERAAKLSAALGGGSLSALPIAETDAGNLAAYIPTNLISITDGQIVLDSALFAANQRPAVDVGLSVSRVGGKAQHPALRAASGRLRLDYAQFLELEAFTRFGGLTDARLRAQITRGERIRALITQPRFRALRTLDEVVLLKALAAGALDAMSPDLVAPLRERLPAWLDARIAALTPALAPPRDWLADDAALDALAESVGELIERIAADAARRATAGMPAEDAAGDIGGAFGGEQARGDADRDADHGANREVSREVSPEASREVSREVSCEVSHEADRDAAADAARVAGRAPGRAEPDRAAPRAMPDGPPRAQADGDRASASRPRPDARGDAARTAPSPQGGADANVDAEAEARHKR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 2, ATP synthase F1 sector subunit alpha 2, F-ATPase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS3_SHESM
Sequence: MGQKVHPNGIRLGITKPWISTWYADKSDYANNLNSDWEVRKYLADKLQAASVSKIVIERPAKSIRVTIHTARPGVVIGKKGEDVEVLRAAVSKLAGTPAQINIAEIRKPELDAKLVADSIAQQLERRVMFRRAMKRAVQNAMRIGAQGIKVEVSGRLGGAEIARSEWYREGRVPLHTLRADIDYSTSESHTQYGVIGIKVWIFKGEVLDGMLPQIEEPKQQQPKRKPRGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: SYE1_EHRCJ
Sequence: MSHDVITRFAPSPTGHLHLGGARTALFNWLYAKHNNGKFLLRIEDTDKKRSSQELIDSIINAMSWLKIHYDGKAVLQSENISRHVEIANQLMLNNKAYYCYCSEEEINKEKEESAKKGLYYKHNCIWKNKSAPNSNITRVVRLKSPTDGVTSFDDEVYGNITVNNSQLDDMILLRSDNTPTYLLSVVVDDHDMNISHIIRGTDHLTNTARQLLIYNALEWDPPKFAHIPLIHDENGNKLSKRHQAIGIHEYKNSGILPEAIFNYLLRMGWSHENDEVITIDQAIRWFSIEGIGQSPSRLDSKKLEFLNNHYINITDNETILNMIIPIIEEKTGHIITDVKKGYLLKGLSELKKRTKNLVNLAKESLFYVEDIPISIDQESITVIKDYKHIFSILYDNLSKISEKDWNHNILMSIIKDISCNLEVKISIVYHCLRASITGRMNAPSIIEIMINLQHKECLQRIKYALDVI
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERPA_PARP8
Sequence: MDAVTDTPVTEMPAPFVFTDAAADKVKELIEEEGNPELKLRVFVQGGGCSGFQYGFTFDEAINEDDTVMNKSGVQLLIDSMSYQYLVGAEIDYKDDINGAQFVIKNPNATTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: RS21_CHLT2
Sequence: MPSVKVRVGEPIDRALRILKKKIDKEGILKTSKSHRFYDKPSVKKRAKSKAAAKYRGR
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: URM11_ARATH
Sequence: MQLTLEFGGGLELLCDSEKIHKVNVDLPNGADSDDFTMKHLLSWVRTNLIKERPEMFMKGDTVRPGVLVLVNDCDWELSGQLDTVIEDKDVVVFISTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_MUSPA
Sequence: MSESELKLVARRIRSFPDFPIPGVLFRDISPLLKDPDSFRASIRLLASHLKSTHSGKIDYIAGLDSRGFLFGPSLAQELGVGCVLIRKQGKLPGPTISASYALEYGKAELEIQKDALEPGQRVVIVDDLLATGGTMFAACDLLHQLRAEVVECVSLVELTSLKGRERLGPIPFFSLLQYD
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LST8_XENTR
Sequence: MNSNQGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQHIRMYDLNSNNPNPVINYDGVSKNITSVGFHEDGRWMYTGGEDCMARIWDLRSRNLQCQRIFQVNAPINCVFLHPNQAELIVGDQSGAIHIWDLKTDQNEQLIPETDVSINSVHIDPDASYMAAVNSSGNCFVWNLTGGLGEDLTQLIPKTKIPAHKRCALKCKFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSNNPGETSRGWMWDCAFSGDSQYIVTASSDNLARLWCVETGEIKREYSGHQKAVVCLAFNDSVLG
What are the official names of this protein?
Target of rapamycin complex subunit lst8, TORC subunit lst8, G protein beta subunit-like, Gable, Protein GbetaL, MTOR associated protein, LST8 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LST8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YX03_CAEEL
Sequence: MPPIIPLNLTLSHILGRIQRKYPNATIDAQRISAHMGEFRVLECYFNMTRVAIRAITYPQDENGKESCASGEVHYHWACFCGVSPNLQVYIIHYKPSGNNVQQKKKNNENLAVRK
What are the official names of this protein?
Uncharacterized protein C03B1.3.
Protein: SMTB_EMENI
Sequence: MSEEKKSVELSGDIDFIETPPAKASQFETGEDCGIEVTKAAAIPNPPLAVDGPGNESFSNYLLGGTLVGLPAFLTWFFGGGAKTFVFFFLLSVLPVLVAFWTYASTFSPRTNEKVKLPGRPVEHYITFKREEDKAKWHGKNKIPMQTFAEMYLDGLVDFNGDTLDVMEYRHDWANFSFTWDLFKFIVGTFFVDVLFHTKAQDEEQVRPNYDSGNDHYAWFLGPRMIYTSGIISDPEKEETLEEMQDNKMAIVCEKIGLKEGETMLDIGCGWGTLARFASLNYGAKVTGLTIAENQTAWGNDALRKAGIPEEQSKILCMDYRDAPRTKFDKITQLEMGEHVGIRRLTGFFRQCYDMLKDDGAMYVQLSGLRQAWQYEDFIWGLYLNKYIFRGADASTPLWYYVKCLEQAGFEVKGIDTVGVHYSGTLWRWYRNWVGNVEAIKAKYGPRWYRIWELFLAWSVIASRQGSATCYQMVVVKNLNSTHRINGVASQFGLAGALAASRAAGKSRLP
What is the function of this protein?
Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position (PubMed:27479571).  Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates (By similarity).  Glucosylceramides play important roles in growth, differentiation and pathogenicity (PubMed:27479571).  The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses (By similarity).
What are the official names of this protein?
Sphingolipid C9-methyltransferase B.
What is the protein family that this protein belongs to?
Belongs to the CFA/CMAS family.
Protein: SYL_CHLL2
Sequence: MRYEFSAIEKKWQAIWQENGTFKTGESTEKPKYYVLDMFPYPSGSGLHVGHLEGYTASDIIARFKRSRGFNVLHPMGWDAFGLPAEQYAIKTGTHPKITTENNIRSFRETLQAMGFSYDWSKEINTTDPAYFKWTQWIFLRLYEMGLAYMSDVDVNWCEELKTVLANEEVDEKIADGYTVVRKPLRQWVLKITAYAERLLADLDELEWPENVKQMQRNWIGRSEGVEIDFELRCHGKNLRVYTTRPDTLFGATYLVVSPEHPLAEKLATADNLKEVKAYISRAKLKTELERTGLQKDKTGVFTGSYAINPATGNPLPVWISDFVLISYGTGAIMSVPAHDSRDWEFAKKFDLPIIEVIKSPHDVNDAVFEGKESVPVNSSNSEITIDGLPFREAFDTMASWLEKKGAGKRTINYKLRDWIFSRQRYWGEPIPIKHYEDGTLRTETILPLTLPDVEAYQPSETGESPLATIHDWLYGSDEFGSFRRETNTMPQWAGSCWYYLRFIDPENSGRLIDPEREKYWMNVDLYIGGAEHAVLHLLYARFWHKVLFDLNVVSTVEPFRKLFNQGMILGEDNEKMSKSRGNVIPADHVLKTYGADAVRLYEMFLGPLEQVKPWNTNGIEGISRFLGKVWRLVYPEQEGNKAELTDETMPEELLRRLHKTIRKVTEDTEALKFNTAIAEMMVLVNELQRNGCRNRTAVESMILLLAPYAPHIAEELWQATGHTGSISNEPFPNYVAGLATDSVVQIAVQVNGKLRGTFSTPAGTPQNSLIETARNVESVMKFLEGKAIMREIVVPDKLVNFAVK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFR1_SCHPO
Sequence: MDDTNQFMVSVAKIDAGMAILLTPSFHIIEFPSVLLPNDATAGSIIDISVHHNKEEEIARETAFDDVQKEIFETYGQKLPSPPVLKLKNATQTSIVLEWDPLQLSTARLKSLCLYRNNVRVLNISNPMTTHNAKLSGLSLDTEYDFSLVLDTTAGTFPSKHITIKTLRMIDLTGIQVCVGNMVPNEMEALQKCIERIHARPIQTSVRIDTTHFICSSTGGPEYEKAKAANIPILGLDYLLKCESEGRLVNVSGFYIENRASYNANASINSVEAAQNAAPNLNATTEQPKNTAEVAQGAASAKAPQQTTQQGTQNSANAEPSSSASVPAEAPETEAEQSIDVSSDIGLRSDSSKPNEAPTSSENIKADQPENSTKQENPEEDMQIKDAEEHSNLESTPAAQQTSEVEANNHQEKPSSLPAVEQINVNEENNTPETEGLEDEKEENNTAAESLINQEETTSGEAVTKSTVESSANEEEAEPNEIIEENAVKSLLNQEGPATNEEVEKNNANSENANGLTDEKIIEAPLDTKENSDDDKPSPAAAEDIGTNGAIEEIPQVSEVLEPEKAHTTNLQLNALDKEEDLNITTVKQSSEPTADDNLIPNKEAEIIQSSDEFESVNID
What is the function of this protein?
Required for cell fusion, independently of fus1.  Appears to have a role in transporting proteins that are involved in mating.  May act as a scaffold to retain cell fusion proteins in the cisternae of the Golgi.  Degraded at the onset of mating and this leads to release of cell fusion proteins.
What are the official names of this protein?
Cell fusion protein cfr1, CHS5-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the CHS5 family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: ATPF_YARLI
Sequence: MPFARVGALSARHYSNQVDPKVKATSILDSIPGNNVLSKTGVLATGVLGSIYAISNELYIVNDESIVLGVFAAFVVVVAKLGGPGYTSWADGYIENMRNILNTTRDKHTDAVKERIGDVSKLKDVVKTTQDLFAVSKDTVKLEAEVFETKQQVVLAAEAKSVLDSWVRYENSVRQREQKLLTETVISKIEKDLKDPKFQQKILQQSVEDIEKLFAKA
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:25759169).  F-type ATP synthases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:27373333).  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (PubMed:27373333).  Part of the complex F(0) domain and the peripheral stalk, which acts as a stator to hold the catalytic alpha/ATP1(3)beta/ATP2(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (PubMed:27373333).
What are the official names of this protein?
ATP synthase subunit 4, mitochondrial, ATP synthase subunit b.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ATPase B chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Note=The F-type ATP synthase complex is anchored in the mitochondrial inner membrane via the F(0) domain with the F(1) domain and the peripheral stalk extending into the mitochondrial matrix.
Protein: IBB_VIGRR
Sequence: SHDEPSESSEPCCDSCDCTKSIPPECHCANIRLNSCHSACKSCICTRSMPGKCRCLDTDDFCYKPCESMDKD
What are the official names of this protein?
Bowman-Birk type trypsin inhibitor.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: BCN5_CLOPF
Sequence: MANNIIPNVSSGDLVGSTPTFPPNAVVRGDFLYLRDVDGNQIPGRTVSDGDEITVLFISNEKNIVLVQYPTSSGYRQGYVTNATSIIKYKDDYSWVNGSTPEPVYDFDKTTQIGTLDPRERAVVLYKVDGMTYVAYDTGKGKLTKSGLVHYEGSGSSTGGGSFNGVAPGEVVPGGFTYENNAEVVGDELYLRDANGNLIPGRSVSVGDKITVLDVGYTKQLALVQYPAGDVVRQGYVTNATNLIRYFNQYSWHNGSTSEEVLDENGGHLGSLNPYEAATLLYEKNGMKHVVYDTNKGPNTKSGYVKYEGAAATRVDIPYPSITNAQKIVYGISGRGRELAAYKVGNGSNSLVFVCAIHGWEDNWAADGIELTRIGNGLIEHFQNAGTNNWSLYIIPVANPDGLSEGFTNNGPGRCTIVGAVDCNRDFPLGFSPGGVPRYHSGSEPLSVSESKSLHDFIQGVKNRTSGEMCVIDLHGWEGAAIGNPEIGEYFRNQFGFGQRSGYGDNRGFMIGWAKSIGAKAALIELPGSTKSHSDVVNGRYLQKIINAVTNLIGGSGGSSSGGSSFSDVSYEATGEVINVQSFLNVREGAGLYTNSIGQLRQGNKVNIVAKNGDWYKIKYGSEYGYVNSGYIIILKNNTSVKLEDWQEDCIKFGWGPITKEKYLEYMDSTRLYKSIENDISQAIKNKSLINVINPLNFSVSEMIACTQIVFNNETTSFFRDEWYSKSNPNFIVKYKKLSNGQIIVLDRINIKKPEKLKTKIPKAAKGAFKDTIKFEFFKGIDGWFTAISGAISIGSDLSVFQSNGELKSNEDIAKALAAAVIVNGVETMFCAFLGGFIAQCIAPEFPIVAAVAGAIVSAIAAFAIGYFVDNHEKEKYLMNSFKGLIDYLF
What is the function of this protein?
May function as an ionophore.
What are the official names of this protein?
Bacteriocin BCN5.
Protein: IF2_CERS1
Sequence: MSDTDGKKPLGLGGGSRSGQVKQSFSHGRTKSVLVETKRKRVVVPKPGASGSSTTTSSPSHLGDPAKRPAGISDAEMERRLAALRAAKLREVEDAKRRADEERQREEERQRRREELEAKEREERERAEALRQKAEDEERARREAEEATRRAEEAKRAPAPAAPQPAPAESRASAPPSAKPGLPPSRKEREREADRDRTTKKDDSRRSGKLTLNEALSGEGGRTRSLAAMKRKQEKARQKAMGFGHKAEKQVRDVQLPETILVQELANRMAERAADVVKALMKMGMMVTMNQSIDADTAELVIEEFGHRAVRVSDADVEHVIDTVEDKAEDLQPRPPIITIMGHVDHGKTSLLDAIRKTSVVSGEAGGITQHIGAYQVKTESGAVLTFLDTPGHAAFTSMRARGAQVTDIVVLVVAADDAVMPQTVEAIKHAKAAKVPMIVAINKIDKPDADPNKVRTDLLQHEVIVEKMSGDVLDVEVSAKTGLGLDELLENIALQAEILDLRANPSRQAQGAVIEAKLDVGRGPVATVLVQYGTLKRGDIFVVGQQWGKVRALINDKGERVDEAGPSVPVEVLGLNGTPEAGDVLNVVETEAQAREIADYREKAARDKRAAAGAATTLEQLMAKAKADADVAELPVVIKADVQGSAEAIVQALEKVGNDEVRVRVLHYGVGAITETDITLAEASQAAVIGFNVRANASARQAANQKSVEIRYYSVIYDLVDDVKKAASGLLKAEVREHFIGYAQIKEVFRITGVGNVAGCIVTEGVARRSAGVRLLRDNVVIHEGTLKTLKRFKDEVKEVQSGQECGMAFERYEDIRPGDVIEIFEREEVQRKLA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRACD_MOUSE
Sequence: MGARAFSHDSIFIPDGGAESEQTVQAMSQDNILGKVKTLQRQLGKNIKFGQRPSNAIPMKKAGSTDASSEEDFVLTSPMEIVTQQDIVPSDTENKSSDTPSSSSPLNLPEAGSDMEEKVAPVKPSRPKRHLSSAGTIESVNLDAIPLAIARLDNSAARHKLAVKPKNQRVSRKHRWLAQDRQNEPGSFESQSSLDQNGQLGEDKHIWHGEEPEPLESHEEKRLHEEYWRELEAKCKRQKAEAAEKRRQEEQRRQALERRLWEESLRQELLEEEEEGEEEEEVKEEGEEGEEVGLQPRAGKVPPEEGHQSGPEEQRCTEQELGGADDPARLEAEERRREQEEAERQAEKLRQREAERQEEEQKQREAERQEEEARQCEAERQAEKLRQREAERQEEEARQREAERQAEKLRQREAERQEEELRQREEAERQEKLRQRDAESQEEELRQREAERQRAQEEDAKGMLQEEEEEAKRIEELKGKETPEPLVEEGPQSPEGESQPWLTDDADQRSPLQRDLEKPGEREREDLESAGQREIAEEPRGEGEPAEQSGDLDAHCGGVDGEGKETAQTDSPQPQERQMEGTPAPEENEATAADIDRKVEELRWQEVDERQTMPRPYTFQVSSGSRQILFPKVNLSPVTPAKDASLAPAAQEPPAPRGAASHALPSALSIPHTAILVTGAQLCGPAVNLSQIKDTACKSLLGLSEEKRPMDVPTVESRAGSGKSRPAPESPSNAAALAEWASIRSRILKNSEGDQRGDREPARAGDEPVPRARCDSRGNVRRTPPVNAKFSIMPAWQKFSDSGAETFRQSLDGESGRKKPGLAPSEETAPQPHAAAQQEVSQEPPDTTDGCKFAKDLPSFLVPGLPSPQKAASRTESTTTLDSETTSDVGNPDPAMPGGEEKASPFGIKLRRTNYSLRFHCDQQAEQKKKKRHSSTGDSVGGATPATGSVSGESEPEATFLKHGPSLPQERKPALSPRKDSAESHSSGHYVAVAQSGLPPASGQTPAPEQDRAVSKMPSMQKPALAPKPASQTPPSSPLSKLSRPHLVELLARRAGKLDSEPSETAKESSDNQPPSPSLPEELKGQKRDEKDVPEKKPASPPLPAGQQERPSLIPETGRKEKPVLQSRHSLDGSKVTEKVETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKETVSVSLQPGSSRASKTAPVHKPAAPSEEKKPETAVSRLQRREQLKKSNTLPTSVTVEISDSAPSAALVKDVTKRFSTPDAAPVSTEPAWLALAKRKAKAWSDCPQIIK
What is the function of this protein?
Involved in epithelial cell integrity by acting on the dynamics of the actin cytoskeleton (PubMed:30361697).  Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin (By similarity).
What are the official names of this protein?
Capping protein-inhibiting regulator of actin dynamics, Cancer-related regulator of actin dynamics.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ATPG_CYAP4
Sequence: MANLKSIRDRIQSVKNTQKITEAMRLVAAAKVRRAQEQVIATRPFADRLAQVLYGLQARLRFEEANLPLLRRREVKKVALLVVSGDRGLCGAYNTNVIKRAAERSKELKAEGIDYTFVLVGRKAIQYFQRREQPIDATYTGLEQVPTAAEASQIADELLSLFLSESVDRVELVYTKFVSLISSRPVVQTLLPLDPQGLEAQDDEIFRLTTRGGRFEVQREKVSSATQSMPQDMIFEQDPLQILDALLPLYLNNQLLRALQESAASELAARMTAMNNASDNAKELIKGLSMTYNKARQAAITQEILEVVGGAEALK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: CHMP3_RAT
Sequence: MGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKEVCVVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEAAEMEIDRILFEITAGALGKAPSKVTDALPEPEPAGAMAASEGDEEDDEEDLEAMQSRLATLRS
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.  ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.  The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis.  ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.  Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested.  Involved in late stages of cytokinesis.  Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 3, Chromatin-modifying protein 3, Vacuolar protein sorting-associated protein 24, rVps24p.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane. Note=Localizes to the midbody of dividing cells.
Protein: RUVB_FRATH
Sequence: MIETDRIISANTAQTNDENVIDRAIRPKTLAEYEGQPAVREQMEIFIQAAKARKDALDHTLIFGPPGLGKTTLSNIIANEMGVELKQTSGPVLEKAGDLAALLTNLEENDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLVGATTRAGLLTSPLRDRFGIIQRLEFYSIDDLSKIVYRSAKLLNLDITTDGAMEIAKRSRGTPRIANRLLRRVRDYAQVKGSGVICFEIADKALSMLKVDPVGFDHMDHRYLLTLMEKFAGGPVGLDTMSAALSEEKGTIEDVIEPYLIQQGYIMRTARGRIATLLAYNHFKLKIPDNLSADQQQTLSI
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RUTD_METEP
Sequence: MAAPVHHEVHGPAGGRTVLLSPGLGGSAHYFAPQVPVLAERFRVVTYDHRGTGRSPGPLEPGHDIAAMARDVLDLLDLLDIGTADIVGHALGGLIALQLALTHPERVGRIVVINGWAVMDLATRRCFAARKALLRHAGPEAFVRAQAIFLYPAPWLSENAARVADDEAQALAHFPGEETVLARIAALETFDATGALPRIPHETLLMAARDDVLVPYTASDILAAGLPNARLDLAPEGGHAHSVTRPEAFNRTLLDFLASP
What is the function of this protein?
Involved in pyrimidine catabolism.  May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously.
What are the official names of this protein?
Putative carbamate hydrolase RutD, Aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Hydrolase RutD family.
Protein: RPOZ_RHOPS
Sequence: MARVTVEDCIDKVDNRFDLVLLAAHRARMISSGSQLTIDRDNDKNPVVSLREIAEQTVSPEDLREELVHSLQKFVEVDEPEQDTVPLIGSVGASVDADDTEVALERMTEEELLKGLEGLAPPEEQPEEDE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.