PharMolix/UniProtQA huggingface dataset:
Protein: CAND1_PONAB
Sequence: MASASYHISNLLEKMTSSGKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLQEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVGLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDGDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDESSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDVFTCTIKRLKAADIDQDVKERAISCMGQIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS
What is the function of this protein?
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.  Acts as a F-box protein exchange factor.  The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein.  Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity).
What are the official names of this protein?
Cullin-associated NEDD8-dissociated protein 1, Cullin-associated and neddylation-dissociated protein 1, p120 CAND1.
What is the protein family that this protein belongs to?
Belongs to the CAND family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Protein: IGHG4_HUMAN
Sequence: ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA
What is the function of this protein?
Constant region of immunoglobulin heavy chains.  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
What are the official names of this protein?
Immunoglobulin heavy constant gamma 4, Ig gamma-4 chain C region.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: RL7_BURCH
Sequence: MAIAKEDILAAVEGMTVLELNELVKAFEEKFGVSAAAVAVAGPAGGGAAAAAEEKTEFTVVLAEAGANKVSVIKAVRELTGLGLKEAKDLVDGAPKPVKEGVDKAAAEEAKKKLEEAGAKVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: AROD_ECO7I
Sequence: MKTVTVKDLVIGTGAPKIIVSLMAKDIASVKSEALAYREADFDILEWRVDHYADLSNVESVLAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLAGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: Y056_LEPBA
Sequence: MSGHSKWATIRRKKGAIDAKRGAIFTRIAKEISVAAKEGGGDQEGNPRLRLAVTKAKAANMPKDNIERAIKKGTGGLEGMVYEECLYECYAPGGVAIMVDVLTDKKSRTTPEIKSILTKLGGSLANAGAVSRLFERKGQLTLKADQISEEALFDLALGAGAEDIQVNDGMYVVLTSPSEYEAVQSALSSKGLNMEESEIKYIPMTTVEVNEKETAEKVMKLIENLEANDDVQGVSSNFELGEGVELD
What are the official names of this protein?
Probable transcriptional regulatory protein LBF_0056.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GFPT1_MOUSE
Sequence: MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSTWWGSQAERGKDKKGSCGLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
What is the function of this protein?
Controls the flux of glucose into the hexosamine pathway.  Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.  Regulates the circadian expression of clock genes BMAL1 and CRY1 (PubMed:23395176).  Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (By similarity).
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, D-fructose-6-phosphate amidotransferase 1, Glutamine:fructose-6-phosphate amidotransferase 1, GFAT 1, GFAT1, Hexosephosphate aminotransferase 1.
Protein: IHFB_ECOLI
Sequence: MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell.  It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations.  Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site.  Relaxosome formation requires binding of IHF and TraY to the oriT region, which then facilitates binding of TraI.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VNFG_AZOVI
Sequence: MSQSHLDDLFAYVEERCLWQFFSRTWDREENIEGVLNQVGRLLTGQEPLRGTPQERLFYADALAMANDVRERFPWASQVNKEEIEFLLDGLKSRLVDVTITRSTNRELNHHLY
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein (component 2) and a component 1 which is either a molybdenum-iron protein, a vanadium-iron, or an iron-iron protein.
What are the official names of this protein?
Nitrogenase vanadium-iron protein delta chain, Dinitrogenase 2 subunit delta, Nitrogenase component I.
Protein: NADE_SHEB5
Sequence: MKAQILREMKVLTAIEPEFEVQRRVAFIKTKLKEARSKALVLGISGGVDSSTAGRLCQLAVDSLNHENSQGGYQFIAVRLPYQIQKDEHEAQLACQFIQPSKLVTVNVHQGVDGVHSATVAALAEAGLPLPDVAKVDFVKGNVKARMRMIAQYELAGLVGGLVVGTDHSAENITGFYTKWGDGACDLAPLFGLNKRQVRQLAAYLGAPESLVHKAPTADLEDNKPLLEDEVALGLTYAQIDDFLEGKDVGKAVEDKLIGIYKATQHKRQPIPTIYD
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: FLGH_SHESA
Sequence: MARYLLLASTLLLAACSSTPKKPIADDPFYAPVYPEAPPTKIAATGSIYQDSQAASLYSDIRAHKVGDIITIVLKEATQAKKSAGNQIKKGSDMTLDPIYAGGSNVSLGGIPLDLRYKDSMNTKRESDADQSNSLDGSISANIMQVLNNGNLVVRGEKWISINNGDEFIRVTGIVRSQDIKPDNTIDSTRMANARIQYSGTGTFAEAQKVGWLSQFFMSDWWPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: Y137_NITSB
Sequence: MTLFIDGDALPNILKPILLRSVERLKIPTKVIANKKIHIGDSPCIEMIIVSQGADRADDMIIELLSPEDLVITADIPLADRVITAGGHAIDHRGTRYSSDNIKHYLAMRNLFESIRESGEITNGPKPFTQKDAHAFANQLSAFLQRLEKRKK
What are the official names of this protein?
UPF0178 protein NIS_0137.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: PHZM_LYSAN
Sequence: MTENNRAGAVPLSSILLQMITGYWVTQSLYVAAKLGIADLVADAPKPIEELAAKTGAKAPLLKRVLRTIASIGVFTETEPGIFGITPLAALLRSGTPDSMRPQAIMHGEEQYRAWADVLHNVQTGETAFEKEFGTSYFGYLAKHPEADRVFNEAQAGYTKQVAHAVVDAYDFSPFKTVIDIGAGYGPLLSAILRSQPEARGILFDQPHVAQAAGKRLAEAGVGDRCGTVGGDFFVEVPADGDVYILSLLLHDWDDQRSIEILRNCRRAMPAHGKLLIVELVLPEGEEPFFGKWLDLHMLVLLGAQERTADEFKTLFAASGFALERVLPTASGLSIVEARPI
What is the function of this protein?
Involved in the biosynthesis of phenazine natural products including myxin, an N(5),N(10)-dioxide phenazine antiobiotic, which has antimicrobial activity.  O-methyltransferase, which converts iodinin (1,6-dihydroxyphenazine N(5),N(10)-dioxide) to myxin (1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide).  Catalyzes both monomethoxy and dimethoxy formation of phenazine natural compounds.  Acts on a wide variety of substrates, catalyzing O-methylation of phenazines with non-, mono- or di-N-oxide.  Highest activity with 1,6-dihydroxyphenazine (DHP) as substrate.  Less active with monohydroxy-containing and monohydroxy-monomethoxy-containing phenazines.  Least active with non-phenazine substrates, such as 8-hydroxyquinoline and 6-hydroxyquinoline.  Is not able to convert 1-hydroxyphenazine to 1-hydroxy-N5-methylphenazine (pyocyanine), hence does not function as an N-methyltransferase.
What are the official names of this protein?
Phenazine O-methyltransferase PhzM, SAM-dependent O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: MNTB_HALH5
Sequence: MNPVVKVDNLSVFYEQHQAIKNIRFQAGPGQMIGILGPNGAGKSTLMKAILGLERYTGTVKVLDKHVRHVRKQIAYVPQRNAIDWDFPVLVEDVVMMGRFAHIPWFKRAGKNDKRLVEESLKKVGMEEYRSRQIGELSGGQQQRVFIARALAQESELFFLDEPFVGIDVTSESIILSLLQELRDRGKTIFVVHHDLSKVEKYFDQVLMLNKELIAYGPVADVYTPEMVAKTYQGNLATFSKKDEVMVVNV
What is the function of this protein?
This protein is probably a component of a manganese permease, a binding protein-dependent, ATP-driven transport system.  Probably responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Manganese transport system ATP-binding protein MntB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: SPO11_ARATH
Sequence: MEGKFAISESTNLLQRIKDFTQSVVVDLAEGRSPKISINQFRNYCMNPEADCLCSSDKPKGQEIFTLKKEPQTYRIDMLLRVLLIVQQLLQENRHASKRDIYYMHPSAFKAQSIVDRAIGDICILFQCSRYNLNVVSVGNGLVMGWLKFREAGRKFDCLNSLNTAYPVPVLVEEVEDIVSLAEYILVVEKETVFQRLANDMFCKTNRCIVITGRGYPDVSTRRFLRLLMEKLHLPVHCLVDCDPYGFEILATYRFGSMQMAYDIESLRAPDMKWLGAFPSDSEVYSVPKQCLLPLTEEDKKRTEAMLLRCYLKREMPQWRLELETMLKRGVKFEIEALSVHSLSFLSEVYIPSKIRREVSSP
What is the function of this protein?
Component of a topoisomerase 6 complex specifically required for meiotic recombination (PubMed:11157765, PubMed:17018031, PubMed:17965269, PubMed:26917763).  Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:26917763, PubMed:19763177).  The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed:11157765, PubMed:17018031, PubMed:17965269, PubMed:26917763).
What are the official names of this protein?
Meiotic recombination protein SPO11-1, AtSPO11-1.
What is the protein family that this protein belongs to?
Belongs to the TOP6A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CO2FB_CONCE
Sequence: MEKLTFLILVATVLLTIHVLVQSDGDKHLKRRPKQYATKRLSALMRGHRQCTPQNVKCEEDDECCSNLECKCSTVPDCNFPKCRP
What are the official names of this protein?
Conotoxin Cap15b.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MES1_SCHPO
Sequence: MVNTDNKENEPPNMEKAHMDSSNALYRVQRPLQRRPLQELSIELVKPSQTITVKKSKKSTNSSSYFAQLHAASGQNPPPSVHSSHKQPSKARSPNPLLSMR
What is the function of this protein?
Specifically required for meiosis II (MII).  Binds to slp1, an activator of the anapahase promoting complex/cyclcosome (APC/C), and counteracts its function in promoting proteolysis of cdc13.  By suppressing the degradation of cdc13 at anaphase I this protein may help maintain a sufficient level of cdc2 kinase activity to complete MII.
What are the official names of this protein?
Protein mes1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DPS_CAMJE
Sequence: MSVTKQLLQMQADAHHLWVKFHNYHWNVKGLQFFSIHEYTEKAYEEMAELFDSCAERVLQLGEKAITCQKVLMENAKSPKVAKDCFTPLEVIELIKQDYEYLLAEFKKLNEAAEKESDTTTAAFAQENIAKYEKSLWMIGATLQGACKM
What is the function of this protein?
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (Probable).  Does not bind DNA.
What are the official names of this protein?
DNA protection during starvation protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGB_ECOLI
Sequence: MSELLSFALFLASVLIYAWKAGRNTWWFAATLTVLGLFVVLNITLFASDYFTGDGINDAVLYTLTNSLTGAGVSKYILPGIGIVLGLTAVFGALGWILRRRRHHPHHFGYSLLALLLALGSVDASPAFRQITELVKSQSRDGDPDFAAYYKEPSKTIPDPKLNLVYIYGESLERTYFDNEAFPDLTPELGALKNEGLDFSHTQQLPGTDYTIAGMVASQCGIPLFAPFEGNASASVSSFFPQNICLGDILKNSGYQNYFVQGANLRFAGKDVFLKSHGFDHLYGSEELKSVVADPHYRNDWGFYDDTVLDEAWKKFEELSRSGQRFSLFTLTVDTHHPDGFISRTCNRKKYDFDGKPNQSFSAVSCSQENIATFINKIKASPWFKDTVIVVSSDHLAMNNTAWKYLNKQDRNNLFFVIRGDKPQQETLAVKRNTMDNGATVLDILGGDNYLGLGRSSLSGQSMSEIFLNIKEKTLAWKPDIIRLWKFPKEMKEFTIDQQKNMIAFSGSHFRLPLLLRVSDKRVEPLPESEYSAPLRFQLADFAPRDNFVWVDRCYKMAQLWAPELALSTDWCVSQGQLGGQQIVQHVDKTTWQGKTAFKDTVIDMARYKGNVDTLKIVDNDIRYKADSFIFNVAGAPEEVKQFSGISRPESWGRWSNAQLGDEVKIEYKHPLPKKFDLVITAKAYGNNASRPIPVRVGNEEQTLVLGNEVTTTTLHFDNPTDADTLVIVPPEPVSTNEGNILGHSPRKLGIGMVEIKVVEREG
What is the function of this protein?
Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.
What are the official names of this protein?
Phosphoglycerol transferase I, Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the OpgB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PKHO1_MOUSE
Sequence: MKKSGSGKRGPPDGNHQSAAPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYVSEKEVKDEKNSQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLARCRQPGTTAPNLIFLAVSPEEKESWINALSSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPASCAESFRVDLDKSVAQLAGSRRRADSDRIQPSSQRASSLSRPWEKPDKGAPYTPQALKKFPSTEKSRCASLEEILSQRDTAPARPLHLQAEESLPPVPAQPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKRKAKDPPQSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTSQHSQYRKSLM
What is the function of this protein?
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).  May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2).  Appears to target ATM to the plasma membrane.  Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival.  Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF.  When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).
What are the official names of this protein?
Pleckstrin homology domain-containing family O member 1, PH domain-containing family O member 1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Note=Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3- phosphate. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.
Protein: MHQN_BACSU
Sequence: MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNLQHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGILNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFDAEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM
What is the function of this protein?
Putative nitroreductase that may contribute to the degradation of aromatic compounds.
What are the official names of this protein?
Putative NAD(P)H nitroreductase MhqN.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAG_VIBCH
Sequence: MDVSLPCIKIQVQTRYIEEQSNPEYQRFVFAYLITIKNLSSQTVQLMSRRWLITDADGKQTVVEGDGVVGEQPRIKANDEYTYSSGTALDTPVGVMQGQYLMIDEQGESFTVEIEPFRLAVPHVLN
What are the official names of this protein?
Protein ApaG.
Protein: BIOF_BACP2
Sequence: MKEFTYLQDELETMKQQGTHQTLKEIDSKQSSTVTLNEQSVIQLSSNNYLGLTSHPRLMKAAKEAIDEFGAGTGSVRTIAGTMTMHERLEKKLAAFKKTEAALVFQSGFTTNQGVLSSILTKDDIVISDELNHASIIDGIRLTKADKKVYGHANMEELEKILKKSMNYRVRLIVTDGVFSMDGDIAPLSEIVRLAEAYDAFVMVDDAHASGVLGENGRGTVNHFKLDGRVHIQVGTLSKAVGVLGGYVAGSAVLIDYLKHKARPFLFSTSHPPAVTRACEEAIEVLLDEPERIETLWENAAYFKEKVIGLGFEVAPTETPIIPMMIGDEALTFRFSKALIERGVFAQGIAFPTVAKGKARIRAIITAEHTKEELDRALTIIEEEAKKLNILD
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase, Alpha-oxoamine synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: ARF_DUGJA
Sequence: MGNLVTHLLDRLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLNEDELRDAVLLVFANKQDLPNAMNPAEITDKLGLHSLRNRSWYIQATCATSGDGLYEGLDWLSTTLKNRSKK
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: Y943_METJA
Sequence: MITMDTIRKALVCFSILSILVLACGCVNTPEKIDININSNTNNGENTEKPINQENQNVNNVENKKESQSTQNIQSYENKEIKNQENHPLQSNQNYEQTNGNFNEENENAMTNVGESEVNYNNEPAYNYYIEITYPDGTIPDKIEEQMLYYIKVIDPIVGGLAGIDIYVDGNYIGTLDDVYGIVECVFYEPGYHTITAEDNGKILASKTVYVEEGTAYNSGESENYDEYDNNYESNDLQQTQTQFSEIEVYVDDIKPSNSIIITKLAMNPGFLASINGISPDIGVNIEMENGEKINLKYVSMDVDLIIDNPNSESITIDKIILNMFDDEGHSLGRGEVSNIVITPGENPVTVKVNIPINKMGYEILRKLSGEEVFAEISGSAYIEGSGEVPFSGEADLLPPLPTPPFPLPPLPPFPTE
What are the official names of this protein?
Uncharacterized protein MJ0943.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FK126_ARATH
Sequence: MELIPDLPETVAYECLLRSSYKQFPLMASVCKLWQREISLSDFFRHRKASGHSQELVVLSQARVDPVKELVSGNKTIPTPVYRISVLELGTGLRSELPPVPGHSNGLPLFCRLVSVGSDLVVLCGLDPVTWRTSDSVFVFSFLTSTWRVGKSMPGGPRSFFACASDSQRNVFVAGGHDEDKNAMMSALVYDVAEDRWAFLPDMGRERDECTAIFHAGKFHVIGGYSTEEQGQFSKTAESFDVTTWRWSPQGEEFLSSEMTMWPPICAAGENGDLYACCRRDLMMMKDDTWYKVGNLPADVCNVSYVAIRRSGNLVVIGSARYGEPSVGYNWDMSNSRWLKLETHDKYEGHVQAGCFLEI
What are the official names of this protein?
F-box/kelch-repeat protein At1g15670.
Protein: AMPN_MANSE
Sequence: MYSLIFLALIGAAFGVPLSTNEDSTRNQNLAALYVLPQTSYPTFYDVRLFIDPGYTEAFHGNVSIRIIPNINIDQITIHAMAMRIDSIRVVSDVNPNEDLFSDFTLATDDTHLLTIRLTRNITALQPHVIHIDYVAQYADDMFGVYVSTYEENGRTVNLVTSQLQPTFARRAFPCYDEPALKAVFRTTIYAPAAYATVRSNTPERRDSLKPNEPGYVKHEFEDTLVMSTYLIAYLVSNFNYIENSQNPIYPIPFRVYSRPGTQNTAEFALEFGQQNMIALEEYTEFPYAFPKIDKAAVPDFAAGAMENWGLVIYREVALLVREGVTTTSVKQNIGRIICHENTHMWFGNEVGPMSWTYTWLNEGFANFFENYATDFVRPQWRMMDQFVIAMQNVFQSDAVLSVNPMTHPVYTPSQIIGTFNAVAYQKSGSVIRMLQHFMTPEIFRRGLVIYIKANSRAAAAPSDLYVALQQALDESSHRIPKPISTIMTEWSTQGGFPVLTVRRTAPNADSVFVAQERYLTDRSLTSTDRWHVPVNWVISSNVNFSDTSPQAWILPTFPATAVDVPGLSNADWYIFNKQQTGYYRVNYDVENWVALARVLNNSHEIIHVLNRAQIVDDAFNLARNGRLHYKNAFEISRYLEMEKDYIPWAAANPAFNYLDIVLSGANSYNLYRYYLLNLTAPMFEDLGFDVKSGEEFVTPYHRNIILDINCRFGNQRCISRAQEILQAFKNNPNQRPNPDIQTLVYCSSLRAGNVENFNFLWNMYLGTSDSSEQSILLSALGCTSNAERRNFYLNQIIDDNSAVREQDRHSIAVSVINSSPEGMNVALDFVVENFHRIQPRVQALTGTTNILNTFARRLTTSAHNEKIDELVRRHESIFSAGERASIAAIRENIAASIAWSNSNAGIVENWLKENYGPPSGAKSLTAGLLVLISLFVAIFNH
What are the official names of this protein?
Aminopeptidase N, AP-N, Apn2, Microsomal aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: GCSH_GRAFK
Sequence: MNIPQELKYTKDHEWVKIDGDTVTIGVTDFAQGELGDIVYVEVETLDETLDKEEVFGTVEAVKTVSDLYMPVSGEIIEFNESLEDEPEKVNEDPYGEGWMIKIKLSDTSELEDLLSADEYKEVVGS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.