PharMolix/UniProtQA huggingface dataset:
Protein: CYB_PODAN
Sequence: MRILKSHPLLKLVNSYLIDASQPSNISYLWNFGSLLLLCLIIQIITGVTLAMHYSPNVLEAFNSIEHIMRDVNNGWLVRYLHSNTASAFFFLVYLHIGRGMYYGSYRAPRTLVWAIGTVILIVMIVTAFLGYVLPYGQMSLWGATVITNLVSAIPWIGQDIVEFIWGGFSVNNATLNRFFALHYLLPFILVALVLMHLIALHDTAGSSNPLGISGNYDRITFAPYYLFKDLITIFIFIFVLSSFVFFMSNVLGDSENYIMANPMQTPAAIVPEWYLLPFYAILRSIPNKLLGVIAMFAAILAIMLLPITDLGRSKGLQFRPLSKFAFWVFVVNFLILMKLGACHVETPFIELGQLSTALYFGHFIIIVPIISLIENTLVDLNTMSKG
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LEUD_VESOH
Sequence: MQKFTTFTSIAIPLKRANIDTDAIIPKQFLKSIKRSGFGANLFDEWRYLDHGEIGMDNSKRPLNMDFVLNQPKYQNAKILLVLKNFGCGSSREHAPWALKDYGFKTIIAPSFADIFYNNCFKNGILPIVQNNNVMDELFSSTDKITINLDAQSININNKNYPFEIDIERKTHLINGLDDISLTLQYINDIKAFEKHYFNKYDWL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: ARGE_SALSV
Sequence: MKNVLPPFIEIYRALIATPSISATEESLDQSNASLITLLAGWFSDLGFNVEVQPVPGTRNKFNMLASTGHGAGGLLLTGHTDTVPFDDGRWTRDPFTLTEHDNKLYGLGTADMKGFFAFILDALRDVDVTKLKKPLYILATADEETSMAGARYFSETTALRPDCAIIGEPTSLQPIRAHKGHISNVVRVLGQSGHSSDPARGVNAIELMHDAIGHIMQLRDSLKARYHYEAFTVPYPTLNLGHIHGGDASNRICACCELHMDIRPLPGMTLNDLNGLLNDALAPVSERWPGRLTVAELHPPIPGYECPPDHQLVEVVEKLLGTKTDVVNYCTEAPFMQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVVHHFCWH
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR391_MIMIV
Sequence: MEQDYLTIDETINIINLNTVNLTQYIDSKTLLIFDNNILLESKFISLQEIFNLLDFILFDIIDFLVKSVLPKIPIVNYNYRITGNKAYERFVDLDTNKILSPTFDIEIVDSIDKIIDFSKIFQHS
What are the official names of this protein?
Uncharacterized protein R391.
Protein: XYLR_STAXY
Sequence: MENNFIVNENEKRVLKQIFNNSNISRTQISKNLELNKATISNILNNLKHKSLVNEVGEGNSTKSGGRKPILLEINQKYGYYISMDLTYDSVELMYNYFDATILKQDSYELNDKNVSSILQILKSNINVSEKYDTLYGLLGISISIHGIVDDEQNIINLPFHKNEKRTFTDELKSFTNVPVVIENEANLSALYEKSLYINSNINNLITLSIHKGIGAGIIINKKLYRGSNGEAGEIGKTLVLESINNNDNKYYKIEDICSQDALIQKINNRLGVTLTFTELIQYYNEGNSIVAHEIKQFINKMTVLIHNLNTQFNPDAIYINCPLINELPNILNEIKEQFSCFSQGSPIQLHLTTNVKQATLLGGTLAIMQKTLNINNIQMNIK
What is the function of this protein?
Transcriptional repressor of xylose-utilizing enzymes.
What are the official names of this protein?
Xylose repressor.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
Protein: REV_SIVM1
Sequence: MRSHTGEEELRRRLRLIHLLHQTNPYPTGSGSANQRRQKRRRWRQRWQQLLALADRIYSFPDPPTDTPLDLAIQQLQNLAIESIPDPPTNIPEALCDPTENSRSPQA
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: MIG_AERPE
Sequence: MLFLDKGRIEALRRRLIEWYRVYGDKDLPWRNTADPWAILVAAFLLRKTTARQVVRVYEEFLRRYPNPKALASAREDEVRELIRPLGIEHQRAKHLIELAKHIEARYGGRIPCSKEKLKELPGVGDYIASEVLLAACGSPEPLLDRNMIRILERVLGVKSAKKRPHTDPKMWSTARRIVPKDPDMAKEFNYGMLDLARKICTARKPLCTECPLNDICIYYNND
What is the function of this protein?
DNA glycosylase that excises thymine from T/G mismatches.  Also has a weak DNA glycosylase activity on uracil paired with various bases.
What are the official names of this protein?
Thymine-DNA glycosylase, ApeTDG, Type II nicking enzyme V.ApeKIP, V.ApeKIP.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
Protein: RLMN_CLOD6
Sequence: MEKKKIVLKNFTEDELKEFMKTIDEKPFRGSQIFSWIYKGAKTFDDMNNIPKSLRNKLEEVSCIGHIDIELKLESKVDNTKKYLFLLDDGNIIETVMMDYDSRVTVCVSNQVGCRMGCNFCASTMDGLIRNLEPWEILDQVIKIQEDTGKRVSNLVLMGSGEPLDNFENTKQFLKIINEKNGLNIGYRHITLSTCGIVPKMYELADLEIAINLALSLHSPYDEERRKIMPVANAYSIEEILNACRYYIKKTNRRVTFEYSLIKGVNDSEKEAKALAKLLKGMLCHVNLIPINKVEEREYEKPDKAFIYKFRDSLEKNNIPATVRMSMGSDISGACGQLRRKYK
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMC_BURVG
Sequence: MPDRLVPATLAFRDDGTLISPEYGDIYYNVAGAFAQANYVFIAGNRLPARWQGSRTFTIVETGFGTGTNFLATWAAWRDDPARCERLHFVSFEKHPFTRDDLRRALSHIVAGTTLSEQATLLADAWPPAVPGFHRIEFEGGRVVLTLALGDARELLPKLVARADAFYLDGFAPAKNADLWSADVFRALARVAADDATFATYSSAGVVKQALVEAGFAYRKMPGLAGKFAMLVGEYAPRWRMRRHEPPRALPVAVREAIVIGAGLAGCALVERLAARGWHVTLIERHAQIASEASGNPAGVFHPLMTRDDNVASRLTRSGFLHALARWRALEHAGHTFARSTRGMIHLAESADDFVRMRDAFDALGAPADHVTLLDADAARAHLNLPVAHGGLLFPHGGAVWPAGLCAAQVAAAGERVTLRTGTEVARLERDGDTWRAIGADGATIAEAPVVVLANAGDAVRLAGLRHVALQPVRGQLTLLPPGTTAPLPCPAIGDGYAVPLDDGTLLIGATFEPDDVDPEIRDAGHLENLARIRHLLPGLVGDVPDVDTLRGRVAFRWVVADRVPLIGPLADEAQAVANARALSGAKARDLPRTAGLYGAFGFGSRGLVWASLGAELIASQLEGEPLPLERELVDAVDPARFLIRALRGRKLG
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_ACTPJ
Sequence: MNSTPKAVVIFSGGQDSTTCLFQAIQEFGVKNVEVVTFQYGQRHAIELEKAAWIAKDLGVKQTLIDTSVIKAITSNAMMEEREIKQEGNTPNTFVDGRNALFLLYTAIYAKGQGIRTIFTGVCETDFSGYPDCRDVFVKSMNVTLNLAMDYNFNIRTPLMYLTKKQTWALADKLGAFDYIRQHTHTCYLGVEGGCHTCPSCVLREKGLNEYLSEKTSGQKNV
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RNH2_CHLPD
Sequence: MTTDYEYSLWPTLSLISGIDEAGRGPLAGPVVAAAVIFPRWFRPRHAGLDKLDDSKKLSPNLREQLAPTIKTFAAFWAVAVIEPDIIDRINIFQATMQAMNNAVASLHQPPELILVDGNRFMPNAPIPYETIVKGDAKVFSIAAASVLAKTHRDAIMTAYGKEYPEYGFERHFGYPTASHIKAIETFGRTPVHRKSFRLKQLGEK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR11_SOLTU
Sequence: MAKAIPKISSRRNGRISSRKGARRIPKGVIHVQASFNNTIVTVTDVRGRVVSWSSAGTSGFKGTRRGTPFAAQTAAANAIRTVVDQGMQRAEVMIKGPGLGRDAALRAIRRSGILLTFVRDVTPMPHNGCRPPKKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRMD_SHIF8
Sequence: MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPKLLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNC50_CAEEL
Sequence: MSSQPRGSGTQPGPSQSPISQRNFRYEPARSGYTSPGQYSTYSTSTADRVGCLTAVRMSAFAKLSRFTRRLVHIRQMDFEFALWQMLYLLIQPSKVYKNFIYRKRTKDQFARDDPAFLVLLALSLLFSSIFYAYALGLEKIGFFTFFLWSVFVDCIGVGVVIATVLWWVSNRFLRKVRDQDVEWGYCFDVHLNAFFPMLILLHVIVPILYPTLIDSPAFLSILLGNTFWFLAACYYVYITFLGYTALPILHKTQYFLYPISFIFMFFVATLTGGWNISRTALNFYHSRAEPHKFAPQHGGL
What is the function of this protein?
Required for cell surface expression of acetylcholine receptors in body-wall muscles.
What are the official names of this protein?
Protein unc-50, Uncoordinated protein 50.
What is the protein family that this protein belongs to?
Belongs to the unc-50 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: PROA_LACP7
Sequence: MEDLLVIGSKAKAAASELSHLVQTKKNEGLLACAKALIIHQKEILSANQLDIENAEKNQMKESLIDRLRLTTNRLEQMADGLRQIVSLKDPIGEVLSSEIRPNGLQILKRRVPIGVIGIIYESRPNVTSDAFGLCFKAGNAVVLRGGSDAIHSNLSIAKVLREALKETGINENAVQLLEDTSRETATKLMKLNEYIDVLIPRGGAGLIKSVVANSTIPVIETGTGNCHIYVDESADFKMALDIIDNAKTQRLGVCNACESLVIHENVLGEFLPQVYQRLTEKQVVFRADEKARAICPQMEEATEEDFATEYLDLLISVKVVKGIEEAIAHINHYNTGHSESIITSDYQNAMKFLEEIDAAAVYVNASTRFTDGEVFGLGAEIGISTQKLHARGPMGLEALTSTKYVVFGNGQIRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD12_BOVIN
Sequence: MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAIVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGYTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 12, 26S proteasome regulatory subunit RPN5.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit p55 family.
Protein: YIDD_PEDPA
Sequence: MKQILLLIIRGYQKFISPMFPPSCRYYPTCSNYSLQAIKRFGAIKGGLMGVARILRCHPFVRGGYDPVPDNFSLKRNQKNSKPRN
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RHOG_MOUSE
Sequence: MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL
What is the function of this protein?
Required for the formation of membrane ruffles during macropinocytosis.  Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity).
What are the official names of this protein?
Rho-related GTP-binding protein RhoG, Sid 10750.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: RBSD_DESRM
Sequence: MKKQGVLHRDLAALIASLGHRDAIVVADSGLPVPPGVNCIDLAVTKGIPPLLPVLQVILYEMVVERVVIADELQVNQSLVKSIADEVTPVSLEVVSHEQLKSLSQRARAVIRTGEWTPYANVILYSGVAF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SULA_SALPK
Sequence: MYTSGYANRSSSFPTTTHNAARTATENAAAGLVSEVVYHEDQPMMAQLLLLPLLRQLGQQSRWQLWLTPQQKLSREWVQSSGLPLTKVMQISQLAPRHTLESMIRALRTGNYSVVIGWMTEELTEEEHASLVEAAKVGNAVGFIMRPVRAHALPRRQHSGLKIHSNLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: Y722_THISH
Sequence: MKLIIVSGLSGSGKSVALNALEDAGYYCVDNLHLGLLSAFVRQLMAPRMPLYELAAVGVDVRSGLEELDHFDDIMAEIRAQGVEAQILFLRADEDILLRRFSETRRKHPLARKGMPLVEALRLERSLLARIAVRADLTLDTTRTNVHQLTHLIRDRVEQAGGDALSLLFQSFGFKHGSPVDSDFVFDVRCLPNPYWEPRLRSLTGRDPDVGAYLDEHAVVQEMFDSLRDFLERWIPCFEAEHRSYMTVSLGCTGGQHRSVYLAERLAAHFRQTRGLNVSTRHRELS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Tgr7_0722.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: PNP_CORA7
Sequence: MSAKNAKKQPNNSVEFLIDDDYGITEAIATLDNGDFGTRTIRFETGQLARQAGGSVTTYLDEDTMLLSTTTASNQPREGFDFFPLTVDVEERMYAAGKIPGSFFRREGRPSTEAILACRLIDRPLRPTFVKGLRNEVQVVVTVLSMDPEEYYDVVAINGASASTQLSGLPVSGPVGGVRMALIADDKHPKGQWVAFPNNEQHERALFEMVVAGRIVKKGRKDDVAIMMVEAGAGVNVAERIKEGAPAPQESTVAEGLEAAKPFIKSLCEAQAGLAERAAKETQEFPLFPPYGDDVYAAVEKAASKKLEKLLTIPGKQDRDDATNEYMEQVEAKLIEDFDDLDEADASKQIRNAFNAVMKDIVRTKILTEGFRIDGRGVTDIRDLGVEVDLIPRAHGSSLFERGETQILGVTTLDMLKMEQQIDSLTPVESKRYMHHYNFPPYSTGETGRVGSPKRREIGHGALAERALLPVIPSREDFPYAIRQVSEALGSNGSTSMGSVCASTLSLYNAGVPLKAPVAGIAMGLVSGEVNGKEKFVALTDILGAEDAFGDMDFKVAGTSEFITALQLDTKLDGIPSHVLADALEQARDARAAILDTMSEVIESPDEMSGLAPRITSVTIPVNKIGELIGPKGKTINAITEETGADVSIEEDGTVYISAATGEAADAAIDRVNSIANPQLPKVGERFLGTVVKTVAFGAFVSLTPGRDGLVHISKLGGDERIEKVEDVVNVGDKIQVEIADIDNRGKISLVPVEED
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUGA_GLARU
Sequence: GLLNTFKDWAISIAKGAGKGVLTTLSCKLDKSC
What is the function of this protein?
Has antibacterial activity against Gram-positive bacteria.
What are the official names of this protein?
Rugosin-A.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NT2NC_HUMAN
Sequence: MWICPGGGGGGGGGGGGGDREDARPAPLCCGRCWRSGCAARPPRMCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERDREVWNGKEHDEN
What is the function of this protein?
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261).  Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954).  Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954).  Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954).  Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).
What are the official names of this protein?
Notch homolog 2 N-terminal-like protein C.
What is the protein family that this protein belongs to?
Belongs to the NOTCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: YQGF_XANC8
Sequence: MPEAGAIRPDATVLGFDVGSRRIGVAVGTALGAGARAVAVINVHANGPDWVALDRVHKEWRPAGLVVGDPLTLDDKDQPARKRAHAFARELRERYALPVVLIDERSSSVEAAQRFARERADGRKRRRDADTLDAMAAAVIVERWLSAPEQATLLP
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD9_MOUSE
Sequence: MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNHSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYKDTYQKLRSKDEPQRETLKAIHMALDCCGIAGPLEQFISDTCPKKQLLESFQVKPCPEAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV
What is the function of this protein?
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:10700183, PubMed:10634790, PubMed:10634791, PubMed:14715942).  Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (PubMed:10700183, PubMed:10634790, PubMed:10634791, PubMed:21690351).  In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (PubMed:23575678).  In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles.  Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (PubMed:12796480).  Acts as a receptor for PSG17 (PubMed:11805154).  Involved in platelet activation and aggregation (PubMed:14715942).  Regulates paranodal junction formation (PubMed:14715942).  Involved in cell adhesion, cell motility and tumor metastasis (By similarity).  Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung (PubMed:18662991).
What are the official names of this protein?
CD9 antigen.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Secreted, extracellular exosome. Note=Present at the cell surface of oocytes (PubMed:10518536, PubMed:10634791, PubMed:23213457). Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO (PubMed:25209248).
Protein: NDRG2_HUMAN
Sequence: MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC
What is the function of this protein?
Contributes to the regulation of the Wnt signaling pathway.  Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor.  May be involved in dendritic cell and neuron differentiation.
What are the official names of this protein?
Protein NDRG2, N-myc downstream-regulated gene 2 protein, Protein Syld709613.
What is the protein family that this protein belongs to?
Belongs to the NDRG family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).
Protein: F216A_HUMAN
Sequence: MLGQLLPHTARGLGAAEMPGQGPGSDWTERSSSAEPPAVAGTEGGGGGSAGYSCYQNSKGSDRIKDGYKVNSHIAKLQELWKTPQNQTIHLSKSMMEASFFKHPDLTTGQKRYLCSIAKIYNANYLKMLMKRQYMHVLQHSSQKPGVLTHHRSRLSSRYSQKQHYPCTTWRHQLEREDSGSSDIAAASAPEMLIQHSLWRPVRNKEGIKTGYASKTRCKSLKIFRRPRKLFMQTVSSDDSESHMSEEKKEEDLLNNFMQSMSIEEQGEHLMLT
What are the official names of this protein?
Protein FAM216A.
What is the protein family that this protein belongs to?
Belongs to the FAM216 family.
Protein: RS9_PSEE4
Sequence: MSATQNYGTGRRKTATARVFLRPGTGNISINNRSLDVFFGRETARMVVRQPLELTETVEKFDIYVTVSGGGVSGQAGAIRHGITRALMEYDETLRGALRRAGYVTRDAREVERKKVGLRKARKRPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.