PharMolix/UniProtQA huggingface dataset:
Protein: FADS2_MACFA
Sequence: MGKGGNQGEGAAEREVPMPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSTQHPGGQRVIGHYAGEDATDAFRAFHPDLKFVGKFLKPLLIGELAPEEPSQDHGKNSKIIEDFRALKKTAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAISYYIRFFVTYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSLRKSGKLWLDAYLHK
What is the function of this protein?
Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain.  Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity).  Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity).  It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity).  In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity).
What are the official names of this protein?
Acyl-CoA 6-desaturase, Delta(6) fatty acid desaturase, D6D, Delta(6) desaturase, Delta-6 desaturase, Fatty acid desaturase 2.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYFB_LEPBP
Sequence: MKLSVDWLNEFTPLSQIPFEKVLEKINTSICEIDDVEEFKSHLSSVITVKIKSLEKHPNAEKLQTTIATDGSKEYQIVTAATNVAVGDIVPLALPGTKLDGKEILDSELRGVRSQGMYCSEKELGMALESSGVLILPKDTTLGISVRKYFLWEDTILTIDNKSITHRPDLWNHFGFARELASQLQIPLHHFPLQADTKWESGNQGLTVEKSEHAHAYYVCSIQNVNITESIPKIKSRLEKCGIRSINNVVDVSNYLLLELGQPTHFFDRSKLQSTSFTVSKSKEGESISLLDDTSPTLPNHILLIQNGETPVALAGVMGGKDSAVSESTKEIVMESAVFKREDVRYTIRKTNIRTESAVRYEKGLDSYTCLPVMKRAVQLLKENGNPNVKVFEPQGFNHTESKTVTIETNLSFLRHKLGKKISLHEVTDILQRLGFEVTTKDESLSVLVPKYRQNYDVTIPEDLVEEIGRTIGYASIRTEALSMAVETPIRNPLRELERRVKQFLALEVGFNEVYNYSFASPTDAKLEKEFEVTSLKIANEMPEEHSLLRNSLYPGLIKQTKVNQDRFEKVNLFELGRTYHKEGNDATLAQEKRWISLLSLSKCKPTDLSSIEDEFLTVRETISELFLFLNLPKFEWVKLPRTHFHPNASLVLLYDGKEVVELGILHTRFADLYDLKRRAILSKIDMEVLVQIWETYGRNSHFVPPSHFPQGQLDLSLIMNESDPTESFANLVKTLRIPELESVFVQTIFQGESVGEGKKSVTYRFILMSYDKTFTQDRFKELSDRLVETAKSNGYSLR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_SYNFM
Sequence: MSVVETVLVALALGCDAFAVGMGVGTRFCNPRQIFRLSFHFGLFQMMMPIAGWFVGSRAADLVSTWGPWISFALLLFIGGKMAYESFRSLEAEDGECPDPTKGSSLVMLSVATSMDALGVGFSFGILGQQLFLSAVWIGITAGIMTWGAMRLGNRLSRQFGRRMETVGGLILVAIAVKLLLF
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTMCB_HALH5
Sequence: MNNQPSFRARVQKFGSFLSGMIMPNIGAFIAWGLITALFIPTGWWPNEQLAELVGPMITYLLPLLIGYTGGKMIYDVRGGVVGAAATMGVVVGADIPMFIGAMIMGPLGGFLIKKVDQVLQPKVRSGFEMLVNNFSAGILAAILAIVAFLGIGPVVVSFSNVLASGVEVIIGAGLLPLASIFIEPAKVLFLNNAINHGILSPIGIDQAASAGKSILFLLETNPGPGLGVLLAFMVFGKGMAKQSAPGAAVIHFAGGIHEIYFPYILMKPTLILAVIAGGMSGVFTFVLFNAGLVAVPSPGSIFALLAMTPRGEYAGVLAGVIIATVVSFVIASIILKTSKATAEDLTEATSKMEGLKGKESSVKEALITDDEQPQATEVNKIIFACDAGMGSSAMGASILRDKVKKAGLSIEVANTSINQLPDDVDIIITHKDLTDRAKAKNPHAEHISVENFLSSPKYDELVNRLKS
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II CmtAB PTS system is involved in D-mannitol transport.
What are the official names of this protein?
PTS system mannitol-specific EIICB component, EIICB-Mtl, EII-Mtl.
Protein: MURC_AROAE
Sequence: MKHKVKRIHFVGIGGAGMSGIAEVLANLGFMVSGSDLGENAATRRLAALGVQVRVGHAAENVAGADAVVISTAVRNDNPEVVAARSRHVPIVPRAQMLAELMRLKHGIAIAGTHGKTTTTSLVASILAEGGMDPTFVIGGKLNAAGANARLGKGDFLVAEADESDASFLLLTPVISVITNIDADHMDTYGHDFARLKQAFVDFLQHLPFYGVAVLCEDDPHVRSIMPLVSKQVVRYGLSESANIRAENVRAEGGRMLFDVVRTNGSVSRLPIELNLPGVHNVLNALAAIAVATEVQVPDAAIIKALAEFRGVGRRFQRYGEVALRDAEGTPQGSCTLIDDYGHHPVEMAATLAAARGAFPGRRLVLAFQPHRYTRTRDCFEDFVKVLSTVDALLLAEVYAAGEAPVVAADGRSLARAIRVAGKVEPVFVEDIDEMPATVLAAVRDGDVVITMGAGSIGAVPGKLASSEELV
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_CUPPJ
Sequence: MQNQKIRIRLKAFDYRLIDQSAAEIVDTAKRTGAIVKGPVPLPTRIQRFDILRSPHVNKTSRDQFEIRTHQRLMDIVDPTDKTVDALMKLDLPAGVDVEIKV
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: TIG_HELP2
Sequence: MNLEVKKIDTANARLSAKPSIENLEKRYDKIAQKIAQKVKIDGFRRGKVPLSLVKTRYQAQIEQDAQEEMIQEVLKNAFKELGIENKDLIGSPNLTKFEKKDTHFEIEADIGLKPTIVLDKIKECVPSVGVEIPNEEKINERLKQLAKDYAKFVDTDAQRKAQNDDKLTIDFEGFIDNAPFEGGKAENFNLILGSKQMLEDFEKALLGMQAGEEKEFPLIFPSGYHAEHLAGKEALFKVKLHQIQVREALEINDELAKIVLANEENATLKLLKERVEGQLFLENKARLYNEELKEKLIENLDEKIVFDLPKTIIEQEMDLLFRNALYSMQAEEVKSLQESQEKAKEKRESFRNDATKSVKITFIIDALAKEEKIGVHDNEVFQTLYYEAMMTGQNPENLIEQYRKNNMLAAVKMAMIEDRVLAYLLDKNLPKEQQEILEKMRPNAQKTQAG
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: APTH1_NEUCR
Sequence: MASLARRPPLLVPAVARHTATVIFIHGLGDTGHGWASAVEQWRRRQRLDEVKFILPHAPSIPITANWGMKMPGWYDIFAIDGSAEALRRNEDEAGILTSQAYFHDLIQKEIDSGIPADRIVIGGFSQGGAMGLFSGLTAKCKLAGIIALSSYLLLSLKFAELVPKPEFNKETPIFMAHGDADPVVNYKLGTMTRDLLKEMGYNVKFTTYPGMGHSACLEELDAIEDFLTERLPKVADKSEQKSEL
What is the function of this protein?
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates.  Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins.  Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
What are the official names of this protein?
Acyl-protein thioesterase 1, Palmitoyl-protein hydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CRK_HUMAN
Sequence: MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
What is the function of this protein?
Regulates cell adhesion, spreading and migration (PubMed:31311869).  Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner.  Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829).  May regulate the EFNA5-EPHA3 signaling (By similarity).
What are the official names of this protein?
Adapter molecule crk, Proto-oncogene c-Crk, p38.
What is the protein family that this protein belongs to?
Belongs to the CRK family.
Protein: ELAC_NOTEU
Sequence: EKCLDQIQVNSLENLSLLVPSLCLLPPVRGNCSSQILHYFYNTTSRTCETFIYSGCNGNRNNFNSEEYCLKTCRRNKNRNNNN
What are the official names of this protein?
Early lactation protein.
What are the subcellular locations of this protein?
Secreted.
Protein: ERG13_ARATH
Sequence: MTYAWLWTLLAFVLTWMVFHLIKMKKAATGDLEAEAEARRDGATDVIIVGAGVAGASLAYALAKDGRRVHVIERDLKEPQRFMGELMQAGGRFMLAQLGLEDCLEDIDAQEAKSLAIYKDGKHATLPFPDDKSFPHEPVGRLLRNGRLVQRLRQKAASLSNVQLEEGTVKSLIEEEGVVKGVTYKNSAGEEITAFAPLTVVCDGCYSNLRRSLVDNTEEVLSYMVGYVTKNSRLEDPHSLHLIFSKPLVCVIYQITSDEVRCVAEVPADSIPSISNGEMSTFLKKSMAPQIPETGNLREIFLKGIEEGLPEIKSTATKSMSSRLCDKRGVIVLGDAFNMRHPIIASGMMVALSDICILRNLLKPLPNLSNTKKVSDLVKSFYIIRKPMSATVNTLASIFSQVLVATTDEAREGMRQGCFNYLARGDFKTRGLMTILGGMNPHPLTLVLHLVAITLTSMGHLLSPFPSPRRFWHSLRILAWALQMLGAHLVDEGFKEMLIPTNAAAYRRNYIATTTV
What is the function of this protein?
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
What are the official names of this protein?
Squalene epoxidase 4, AtSQE4, Squalene monooxygenase 2, SE 2.
What is the protein family that this protein belongs to?
Belongs to the squalene monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PXMT3_ARATH
Sequence: MSPTPEWVMVGGEGPESYKQHSSYQRDLLKAAKDKINAVISTNLSLNLISNRFSVADFGCASGPNTFVAVQNIIDAVEEKYLRETGQNPDDNIEFQVLFNDLSNNDFNTLFQGLPSGRRYYSAAIPGSFFDRVLPKHSIHIGVMNYAFQFTSKIPKGISDRNSPLWNRDMHCTGFNNKVKKAYLDQFSLDSKNILDARAEELVPEGLMLLLGSCLRDGIKMSETYRGIVLDLIGASLNDLAQQGVIEKDKVESFNITLYIAEEGELRQIIEENGKFTIEAFEDIIQPNGESLDPKILAVSLKSAFGGILSAHFGAEAMMKAFELVEAKAHQEFSRLQNAKPTMQYLIVLRKN
What are the official names of this protein?
Paraxanthine methyltransferase 3, SABATH methyltransferase PXMT3.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. SABATH family.
Protein: DF260_ARATH
Sequence: MKIASLKLLLLVSLLFAVTQNGISIQNSETSVNQNSCMPNEPRCTGCPGGGSGGYRGPPPPCCKNDSDCKAHCPEGGYCSNQCDCVCNLVKVMNNDVRCQVDTDCNMKCSKQGYCKLAS
What are the official names of this protein?
Defensin-like protein 260.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: HAL9_YEAST
Sequence: MENQGGDYSPNGFSNSASNMNAVFNNEITGRSDISNVNHQTGTPRLVPETQIWSMPVPDQLMTMPNRENTLMTGSTIGPNIPMNVAYPNTIYSPTEHQSQFQTQQNRDISTMMEHTNSNDMSGSGKNLKKRVSKACDHCRKRKIRCDEVDQQTKKCSNCIKFQLPCTFKHRDEILKKKRKLEIKHHATPGESLQTSNSISNPVASSSVPNSGRFELLNGNSPLESNIIDKVSNIQNNLNKKMNSKIEKLDRKMSYIIDSVARLEWLLDKAVKKQEGKYKEKNNLPKPARKIYSTALLTAQKLYWFKQSLGVKASNEEFLSPISEILSISLKWYATQMKKFMDLSSPAFFSSEIILYSLPPKKQAKRLLENFHATLLSSVTGIISLKECLDLAEKYYSESGEKLTYPEHLLLNVCLCSGASATQSIIRGDSKFLRKDRYDPTSQELKKIENVALLNAMYYYHKLSTICSGTRTLQALLLLNRYFQLTYDTELANCILGTAIRLAVDMELNRKSSYKSLDFEEAIRRRRMWWHCFCTDKLYSLMLSRPPIVGERDMDMLTDQNYYEVIKTNILPDLIDKKEDLDKITDVNSALNVVVNFCQHISLFISYYVSKLVSIESKIYSTCFAVRSTLDLSFDAMLDKIKDLNDSLNNWRDNLHVSMKLKSYKQYLSVLYAQKSQENPALSFEIACSRVLNCHFRALYSKVILSMMTTSLLIDNERLYKGSRHDIPQLFILFSSQYLNASKEMLQLFQGINYQAHMYNEVMYQFSTAMFVLFFYVVDNMNDLKKKGEVKEIIDILKKSYDRLVGENDEQLLFDNVKWNTLIVFYSHFLKYVLQRYHALNDSTSIFDSKPYDETITKVIMHSRKIKDETVDQLIMSLKSYGSLHSLQKGNEADLADDGLNTNDISSEDFAEEAPINLFGELSVEILKLLKSHSPISNFGDLSPSSNRKGISDDSSLYPIRSDLTSLVYPIHSSDTGDTLSSGLETPENSNFNSDSGIKEDFEAFRALLPLGKLIYDRDYSFVNTFRDYE
What is the function of this protein?
Putative transcription factor involved in halotolerance.
What are the official names of this protein?
Halotolerance protein 9.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: OFCC1_MOUSE
Sequence: MDKEKFQQKAVKQTKQKKSTSAEFLMVKEYTDATEGAGNPGFNMSSPELPAHQTPQEKVVRHDMLDHTLATHQQKSRLPASAGPKGVTSVLIVLTLAALLIRPGCPEREPGIPLKRACTASVEDLFGARVGGDAAEDLCTHWVQVTHSFVGEGYERMNSLFFGRLR
What are the official names of this protein?
Orofacial cleft 1 candidate gene 1 protein homolog, Orofacial clefting chromosomal breakpoint region candidate 1 protein homolog.
Protein: QUEF_STRTD
Sequence: MSQQEEMKNLTLLGSKETPYIFEYSPQVLESFDNRHADNDYFIKFNCPEFTSLCPITGQPDFASIYISYIPDQLCVESKSLKLYLFSYRNHGDFHENCINTIGKDLVELLNPRYLEVWGKFTPRGGISIDPYYNYGRPKTKYENMAEQRLFNHDLYPENIDNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_GLOVI
Sequence: MATAVRAHVWVGGKVQGVYFRAATREAAQRQGVAGWVRNLPDGRVEAVFEGPPAAVQRLIDWCRQGPPAAVVEQLRVAYELPEGLTHFEVLRS
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: PDIA3_HUMAN
Sequence: MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKPKKKKKAQEDL
What is the function of this protein?
Disulfide isomerase which catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds (PubMed:7487104, PubMed:27897272).  Associates with calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:27897272).  Association with calcitriol does not affect its enzymatic activity (PubMed:27897272).
What are the official names of this protein?
Protein disulfide-isomerase A3, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, p58, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 57, ER protein 57, ERp57, Endoplasmic reticulum resident protein 60, ER protein 60, ERp60.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
Protein: Y447_STRP8
Sequence: MFQKQERIGLVVYLYYNRDARKLSKFGDLYYHSKRSRYLIIYINKNDLDTKLEEMRRLKCVKDIRPSAFDDIDRQFVGNLHRDETNNHQKG
What are the official names of this protein?
UPF0298 protein spyM18_0447.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDGD_STRSQ
Sequence: MTDTTSEQTERKLLDELYADFEDAGLIPLWTQVDGLMPMSPQPAAVPHLWRWAELLPIAQRSGELVPVGRGGERRAMALSNPGFPGLPYATPTLWTAIQYLGPREVAPSHRHSQGAFRFVVEGEGVWTNVDGDAVAMRRGDLLLTPSWAFHEHQNVTDEPMAWLDGLDIPLVSKLDAGFFEFGPDELSTRETPERSRGERLWGHPGLRPIGRPDQPNSPLNAYRWEHTDAALTAQLELEQEGVPGVLEPGHAGVRFSNPTTGRDALVTMRTEMRRLRAGTRTAPVRTVGSAIWQVFEGEAVARVGDKVFEIAKGDLFVVPSWCEVSLSARTQVDLFRFSDEPVYEALGLARTSRGEHK
What is the function of this protein?
Involved in the degradation of salicylate via a pathway involving coenzyme A derivative.  Catalyzes the oxygen-dependent ring fission of gentisate between the carboxyl and proximal hydroxyl groups at positions 1 and 2 of the aromatic ring to form maleylpyruvate.  The substrate specificity is strong, since salicylate, catechol, protocatechuic acid, homogenetisate, 2,3-dihydroxybenzoate or 5-aminosalicylate cannot substitute for gentisate in the ring cleavage reaction.
What are the official names of this protein?
Gentisate 1,2-dioxygenase, GDO.
What is the protein family that this protein belongs to?
Belongs to the gentisate 1,2-dioxygenase family.
Protein: CRCB1_YERPE
Sequence: MFNTLLAVFIGGGVGSMARWLVSLKLNSASAHLPVGTLIVNLVGAFIIGLTLAFFSRMTHIDPVWKLLITTGFCGGLTTFSTFSVEVVYLIQEGKLAWAAGTILLNVAGSLAMTMLAFILVNNFASQ
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CFR_CLOBL
Sequence: MKQTKTKYGKMKQIVSNLKLPDYRYEQLTKAIFHQRIDNFDDMHILPKVLRMSLVNEFGKNVSSVIPVFSQDSKQAQKLLFELTDGERIEAVGLKYKQGWESFCISSQCGCGFGCRFCATGSAGFKRNLTADEITDQLLYFYFNDHRLNSISFMGMGEAFANPELFDAVKILTDQNLFGLSQRRITISTIGIIPGIQSLTQKFPQVNLAFSLHSPFESQRSDLMPINKRFPLNQVMKTLDEHIIHTGRRVFIAYIMLEGINDSKEHAEAVVGLLKNRGSWEHLYHIDLIPYNSTDKTTFKFQSSNAIKQFCSTLKKAGISATVRTQFGSEISAACGQLCYENEL
What is the function of this protein?
Specifically methylates position 8 of adenine 2503 in 23S rRNA.  Confers resistance to some classes of antibiotics.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase Cfr, 23S rRNA (adenine(2503)-C(8))-methyltransferase, 23S rRNA m8A2503 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_ALKOO
Sequence: MKITYKSAGVDVDEGQRAVQLMKNHVKSTFNSNVLADIGGFGGLFSLNIKDYKEPVLVAGTDGVGTKLKIAFMMDKHDTIGQDCVAMCVNDILCQGGKPLFFLDYVATGKLVGEKIAQIVGGIAEGCRKAGSALIGGETAEMPGLYAENEYDLAGFAVGIVDREQIITGANIKAGDIILGLPSNGIHSNGYSLVRKLFFEVLDMKITDYVEEFGTTLGEELLKPTKIYVKEILSLIEAIPVKGISHITGGGFFENIPRILPENVDAKINVDAWQIPPIFKFMAEKGNMSKDDIFGTFNMGIGMVVVVSKEDVNGAIAVLNKAGQEAHIIGEVVEGAKQVIL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_RHOPT
Sequence: MFKVRVIPCLDVKDGRVVKGVNFVDLRDAGDPVEAAIAYDAAGADELCFLDITATHENRGIMLDVVRRTAEACFMPVTVGGGVRTVDDIKTLLRSGADKVSINSAAVARREFVKEAAEKFGDQCIVVAIDAKRVPGRDRWEIFTHGGRKGTGIDAIEFAQEVVSLGAGEILLTSMDRDGTKSGFDIPLTRAIADSVGVPVIASGGVGNLDHLVDGIREGHATAVLAASIFHFGEYTIRQAKDHMVQAGLPMRLDP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP156_HUMAN
Sequence: MEPEINCSELCDSFPGQELDRRPLHDLCKTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIVKMSSPNLNIVTLLGSCLTYSSAYLFGIQDVLVGSSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVIIKDLQLLGLVAALLMADVILLMTWVLTDPIQCLQILSVSMTVTGKDVSCTSTSTHFCASRYSDVWIALIWGCKGLLLLYGAYLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEEENQTIRRMAKYFSTPNKSFHTQYGEEENCHPRGEKSSMERLLTEKNAVIESLQEQVNNAKEKIVRLMSAECTYDLPEGAAPPASSPNKDVQAVASVHTLAAAQGPSGHLSDFQNDPGMAARDSQCTSGPSSYAQSLEGPGKDSSFSPGKEEKISDSKDFSDHLDSGCSQKPWTEQSLGPERGDQVPMNPSQSLLPERGGSDPQRQRHLENSEEPPERRSRVSSVIREKLQEVLQDLGLGPEASLSTAPSCHQQTWKNSAAFSPQKMPLSKELGFSPYMVRRRRAAQRARSHFPGSAPSSVGHRANRTVPGAHSRLHVQNGDSPSLAPQTTDSRVRRPSSRKPSLPSDPQDRPGTLEGSKQSQTEPEGARGSKAAFLRQPSGSGRAPSPAAPCLSKASPDLPEQWQLWPPVPSGCASLSSQHSYFDTESSSSDEFFCRCHRPYCEICFQSSSDSSDSGTSDTDPEPTGGLASWEKLWARSKPIVNFKDDLKPTLV
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 156, G-protein coupled receptor PGR28, GABAB-related G-protein coupled receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL20_ACIET
Sequence: MPRVKRGVTARARHKKVLALAKGFRGRRGNVFRIAKQAVMKAGQYAYRDRRTKKRVFRQLWIARINAAARELGLTYSQFANGLKKASIEVDRKMLADLAVHDKAAFGSIVEQVKAKLAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: DEN2A_HUMAN
Sequence: MDMFSLDMIISDPAAEASRAGKKQLRGVQNPCPSARARPRHKSLNIKDKISEWEGKKEVPTPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEAKNGMRPGTESTEKERNKGAVNVGGQDPEPGQDLSQPEREVDPSWGRGREPRLGKLRFQNDPLSVLKQVKKLEQALKDGSAGLDPQLPGTCYSPHCPPDKAEAGSTLPENLGGGSGSEVSQRVHPSDLEGREPTPELVEDRKGSCRRPWDRSLENVYRGSEGSPTKPFINPLPKPRRTFKHAGEGDKDGKPGIGFRKEKRNLPPLPSLPPPPLPSSPPPSSVNRRLWTGRQKSSADHRKSYEFEDLLQSSSESSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDIELHGRCLGKKCVLNFPASPTSSIPDTLTKQSLSKPAFFRQNSERRNFKLLDTRKLSRDGTGSPSKISPPSTPSSPDDIFFNLGDPQNGRKKRKIPKLVLRINAIYEVRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSLARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B.  Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.  May play a role in late endosomes back to trans-Golgi network/TGN transport.
What are the official names of this protein?
DENN domain-containing protein 2A.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Associated with actin filaments.
Protein: YBC9_YEAST
Sequence: MCANIPEFDSFYENENINYNLESFAPLNCDVNSPFLPINNNDINVNAYGDENLTYSNFLLSYNDKLATTTAKNNSINNSNSNNNSNNNKNNNNNHNNNNLLGNDISQMAFLLDYPSTLNEPQFAVNCKDIYRKDISTPSSLVSSLPPAKFSLSLSNSPSPPPPSSSSLKHGEAIISNTSESSDIFADPNSFEKDTMPLTQELTLENLNNQLNYPDFTINAIEQDPAPSSFSSSSSSSESTVSSSRKRKPCHDSYTHSSPSSSESKKISDSRLSAEGLAKVLNLESPEEALKRERFILGIFQNELNYPLGYKTWIRDTTKEYRTKLINQLHERVKVKYPEYNQSILETIIRRGTYYMMQSRLRRERRMKLKERKRTT
What are the official names of this protein?
Uncharacterized protein YBL029W.