PharMolix/UniProtQA huggingface dataset:
Protein: REEP6_RAT
Sequence: MDGLRQRFERFLEQKNVATDALGALEARTGVEKRYLAAGALTLLGLYLLFGYGASLLCNVIGFVYPAYASVKAIESPNKEDDTVWLTYWVVYALFGLVEFFSDLLLFWFPFYYAGKCAFLLFCMTPGPWNGALLLYHRVIRPLFLKHHVALDSAASQLSGRALDIAAGITRDVLQALARGRTLVTPASASESPAALEPDPKSSQTTLLKHK
What is the function of this protein?
Required for correct function and survival of retinal photoreceptors (By similarity).  Required for retinal development (By similarity).  In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity).  May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).
What are the official names of this protein?
Receptor expression-enhancing protein 6, Polyposis locus protein 1-like 1.
What is the protein family that this protein belongs to?
Belongs to the DP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Multi-pass membrane protein.
Protein: ILVD_ECOL5
Sequence: MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDSQSDQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVELTKRYYEQDDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVKNVLGLTLPQTLEQYDIIVTQDDAVKNMFRAGPAGIRTTQAFSQDCRWDTLDDDRSNGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGSIGLIEDGDLIAIDIPNRGIQLQVSDAELAARREAQEARGNKAWTPKNRERQVSFALRAYASLATSADKGAVRDKSKLGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: DGKG_MOUSE
Sequence: MSEEQWVSLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLRQYDPHKPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRQETPDHPKEGASSSEPNVSDYNSDNAAKADEACAPDTESKTTKTQAPSKELEAAAPWEDPGALASSSDAPVVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENGLLDQAEMDQIVSQMLHVAQYLEWDPTELRPILKEMLQGMDYDKDGFVSLQEWINGGMTTIPLLVLLGMDDSGSKGDGRHAWTLKHFKKPTYCNFCRAMLMGVGKQGLCCIYCKYTVHQRCVSKTIHGCVKTNSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTVCDGGELKDHILLPTSICPVSGDRQGGKSDGSVAAKGELVTQYKIIPSPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPEQVFNLDNGGPTPGLNFFHDTPDFRVLACGGDGTVGWILDCIDKANFTKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKEIEQSPLVMLDRWYLEVMPREEVENGDQVPYNIMNNYFSIGVDASIAHRFHMMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVEVDLSNIFLEGIAILNIPSMYGGTNLWGETKKNRAVIRESRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTNKLLPMQVDGEPWMQPQCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
What is the function of this protein?
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:32033984).  Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:32033984).  Has no apparent specificity with regard to the acyl compositions of diacylglycerol (By similarity).  Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma (PubMed:32033984).  Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (PubMed:32033984).
What are the official names of this protein?
Diacylglycerol kinase gamma, DAG kinase gamma, 88 kDa diacylglycerol kinase, Diglyceride kinase gamma, DGK-gamma.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton.
Protein: EX7L_CORGB
Sequence: MSSEKASSKSTPEAPWPVREVNTQVKQWIERLGHLWVEGQLAQINVKPNWKLSYLTLRDVEQEVSVQLTCPTDIIRNRPTPLKDGDRVIVYGKPAFYAGRGTFSLWVTDIRPVGIGELLARIEELRKRLAAEGLFDPARKKRLPFLPNRVGLITGRGSAAERDVLSVAKDRWPEVQFEVINTAVQGASAVPEIIEALRALDQDPRVDVIIIARGGGSVEDLLPFSEEALQRAVAAAQTPVVSAIGHEPDTPVLDNVADLRAATPTDAAKRVVPDVAEERMLINQLRSRSAAALRGWVQREQQALAAIRTRPVLADPMTPINRRRDEIAQAVGLIRRDVTHLVRTEQALVASLRAQVSALGPSATLARGYSVVQVIPRDGSAPEVVTTIEQSPPGSQLRIRVADGSITAASMGTQQAN
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_MYXXD
Sequence: MATPINPNDLDLTDRVVNINRVAKVVKGGRRFSFAALVVVGDGAGHVGVGLGKANEVPEAIRKGGENAKKNLFRVPLVGHTIPHEVLGHFGAGWVLLKPATQGTGVIAGGAVRAVLEAAGIRNILTKSQGSRNPHNVLKATVAGLKLLRSAEQVSRLRGKDVEPAKLAGEQRG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: ISPH_XANAC
Sequence: MDVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEELDEVPDDATVIFSAHGVSQAVRQEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIGHAGHPEVEGTMGQWSRERGAGTIYLVEDIEQVATLDVRQPDNLAYTTQTTLSVDDTMGIIEALRARYPAMQGPRHDDICYATQNRQDAVRDLARQCDLVLVVGSPNSSNSNRLSELARRDGVESYLIDNASEIDPAWIVGKQHIGLTAGASAPQVLVDGVLERLRELGAAGVSELEGEPESMVFALPKELRLRLVS
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: P3H2_MOUSE
Sequence: MRESTWVSLLLLLLLPTPQRGGPQDGRRSPEPEPERGPLQPFDLLYASGVAAYYSGDYERAVRDLEAALSSHRRLRDIRTRCARHCAARRPLAPPGAGPGAELPFFRAVLERARCSRSCQSQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRAYIKLNQLEKAMEAAHTFFMANPEHMEMQQDLEDYKATARVEAPLLDREAKPHLESYNAGVKHYEADDFESAIKYFEQALREYFNEDMECRALCEGPQRFEEYEYLGYKGGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLMFHPDNEDVLDNVDFYESLLDDSTDPASIEAREDLTAFVKRHKLEAELIKLAAEGLGFSYAEPNYWISYGGRQDENRVPSGVNMDGAEVHGLSMGKKSPPKIGRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSQEQCRELHSVANGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKFGYEGRVPLKSARLFYDISEKARKIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFDGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTRGQRCAVALWFTLDPLYRELERIQADEVIAILDQEQRGKHGLNINPKDEL
What is the function of this protein?
Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:24368846, PubMed:25645914).  Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (PubMed:25645914).  Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1.  Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline.  Has no activity on substrates that have proline instead of 4-hydroxyproline in the third position (By similarity).
What are the official names of this protein?
Prolyl 3-hydroxylase 2, Leprecan-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the leprecan family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Sarcoplasmic reticulum. Golgi apparatus.
Protein: ATPE_ANTAG
Sequence: MTLNLRVMAPNRIVWNSEVEEIVLSTNSGQIGVLPNHAPLLTALDIGIIKIRLNGEWSTMALMGGFAMIDNNGMTILVNEAEKATEINPQEARENYKMAQKDLAKAEGGKQKIEANLAFKRAKARLEAIDVISFPVSN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: HFQ_THEM4
Sequence: MAEKFNLQDRFLNILRTSKIPVKVYLVNGFQTKGIIRSFDNFTMLLENGNQQNLIYKHAVSTIMPESFVRLTSKQQQEGKDSDEEE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: BIOB_GRAFK
Sequence: MALKHDWTKEEILEIYNKPFMELLYDAATIHREHHDPNTVQVSTLLSIKTGGCPEDCGYCPQAARYHTDLEGNDLMSVNQVKAQALRAKASGSSRVCMGAAWRNVKDGEEFDNVLEMVRSINKLDMEVCCTLGMLTENQAQRLAEAGLYAYNHNLDSSEEYYKEVISTRGYQDRLDTIGNVRKTNVTVCSGGIIGMGESEADRAGMLVALSTLNPQPESVPINALVPVEGTPMEEQEPVPIWEMIRMVATTRIVMPETQVRLSAGRTQMSREGQAMCFFAGANSIFAGDKLLTTPNPDVSEDMEMFKMLGLNPQKAFEKKSQPESVAAEKSKYQSQGEKPRWSRPEHKIDRNLEAQQNAKTKA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RNY1_LEVBA
Sequence: MSVPIVILAIIAIVVGVVGGYYLRKSVHERKLDAAKYTAAGVLAEAKKQAETATKEALLEAKEDSHKYRAEVETELKERRAEVQKQEDRLIQREETLDRKDNSLEKRENSLNRRDKKLSAEEQNLVKKQQQADSLIEKRQAAVEAVAALSQDDARELIISEAKTALASERAKMIKESEETARKTAQANAKDLIVSAIQRSAADMVTETTITVVTLPNDDMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVVLSGFDPLRREVAKIALEKLIQDGRIHPARIEEMVAKAKKELDEHVRELGEQATFDLGIHSMHPELVKLVGRLNFRISHGQNALAHSIEVAKITGVLAAELGEDVTLAKRAGLLHDIGRAAEHEDDNSYITTGMELTKKYRESSVVVNAIAAQAEETAAQSVIAELVSTADIISATRPGARSDSLESYIHRLDKLETIANEFDGVDHSFAIQAGREVRVIVRPDRISDTDAVVLARDIKQQIEGDLDYPGHVKVSVIREVRSVEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y 1, RNase Y 1.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RSMB_ECO45
Sequence: MKKQRNLRSMAAQAIEQVVEQGQSLSNILPPLQQKVSDKDKALLQELCFGVLRTLSQLDWLINKLMARPMTGKQRTVHYLIMVGLYQLLYTRIPPHAALAETVEGAVAIKRPQLKGLINGVLRQFQRQQDELLAEFNASDARYLHPSWLLKRLQKAYPEQWQSIVEANNQRPPMWLRVNRTHHSRDSWLALLDEAGMKGFPHADYPDAVQLETPAPVHALPGFEEGWVTVQDASAQGCMTWLAPQNGEHILDLCAAPGGKTTHILEVAPEAQVLAVDIDEQRLSRVYDNLKRLGMKATVKQGDGRYPSQWCGEQQFDRILLDAPCSATGVIRRHPDIKWLRRDRDIPELAQLQSEILDAIWSHLKSGGTLVYATCSMLPEENSLQIKAFLQRTADAELCETGTPEQPGKQNLPGAEEGDGFFYAKLIKK
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_CHRVO
Sequence: MNSSILVINCGSSSLKFALIDSASHEAVMTGLAEKLGLADACITFKHNGDKQTALLSAPDHAAAMHAIIEKLQQVSLLDSVKAIGHRVVHGGEHFKQSALLDETAINEIERCIKLAPLHNPAHILGIRTAIKEFPSLPQVAVFDTSFHQTMPEKAYLYAVPMKLYRENSLRRYGMHGTSYRFVAEEAAKMLGKPANETSLVIAHLGNGASISAIRNGKCADTSMGLTPLEGLVMGTRSGDIDPSVFGYLATERGMDIQSITNMLNKESGLLGLSELSNDCRELEEAAAKGHEGAKRALEVFAYRLAKYVASMSVGAGRLDAVVFTGGIGENSSFLRAEVINQLGFLGLKLDAAANEACIRGNAGRITAADSVPALVINTNEELMIAMDTAKLAGLAN
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYP37_ARATH
Sequence: MASPLSSSTVVSHRLFFLHPSPLNRKFLFVKPKLPFNRTNSGDFRMRLHSTSSKTGTKELIHSCNSSIDSKLNTFEAGSKNLEKLVATILIFVQVWSPLPLFGLDSAYISPAEAVLYSPDTKVPRTGELALRRAIPANPSMKIIQASLEDISYLLRIPQRKPYGTMESNVKKALKVAIDDKDKILASIPVDLKDKGSELYTTLIDGKGGLQALITSIKKQDPDKVSLGLAASLDTVADLELLQASGLSFLLPQQYLNYPRLAGRGTVEITIEKADGSTFSAEAGGDQRKSATVQIVIDGYSAPLTAGNFAKLVTSGAYDGAKLNTVNQAVITEDGSGKVESVSVPLEVMPSGQFEPLYRTPLSVQDGELPVLPLSVYGAVAMAHSENSEEYSSPYQFFFYLYDKRNSGLGGLSFDEGQFSVFGYTIAGKDILGQIKTGDIIKSAKLIEGQDRLSLPVQNNNINEST
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase CYP37, chloroplastic, PPIase CYP37, Rotamase CYP37, Thylakoid lumen PPIase of 38 kDa, TLP38, p38.
Protein: RL35_CAMJR
Sequence: MPKMKSVKSAVKRFKVGKNKIKRGSAFRSHILTKKPAKRMRDLRTAKYVHSTNVKAVEKMLGI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: HYPA_METST
Sequence: MHELSMANSMVEAILDTAKKNNAIKITEAILEVGELTMLNPEQLRFMMDILREDTIFEDAEIIINMIPIEVECEDCGFHGISKTDEGMDHLMAVATCPECDNTHVHILKGQECNIKTIKIEREDENA
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: USPE_SALTY
Sequence: MAMYQNMLVVIDPNQDDQPALRRAVYLHQRIGGKIKAFLPIYDFSYEMTTLLSPDERTAMRQGVISQRTAWIREQAKYYLEAGVPIEIKVVWHNRPFEAIIQEVIAGSHDLVLKMAHQHDRLEAVIFTPTDWHLLRKCPSPVWMVKDQPWPEGGKALVAVNLASEEPYHNALNEKLVKETLQLAEQVNHTEVHLVGAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFSIDEKVTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVIDHLRCDLLVIKPDEYQTPVELDDEDD
What is the function of this protein?
Required for resistance to DNA-damaging agents.
What are the official names of this protein?
Universal stress protein E.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_RHOBA
Sequence: MNNDEVKPQHLYLTGYRGCGKSTLAKLLAQKLSLPSVDLDDVIETTAGKSIAEIFANETEVGFRDREEAALMEVSRRPQHVIALGGGTILREANRNIIANSGWCVWLDAEPDVLVARLAGDATTADRRPSLTDQSVFDEVQSVMSHREPLYRASADLRIDTSHRNMDEILTEVLKAAPSSIGQADLS
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_SALAI
Sequence: MKPNIHPEYVTTEVTCSCGNTFTTRSTAKGGSIHVETCSACHPFYTGKQRVLDTAGRVAKFQQKYAKVQAKKGK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: CCR4_ASPFU
Sequence: MYSQTHQGQHVMMNGGQAHQRFGMQIPKFQSQSHHPHHTQQPHHHTHHNQASHNINHQHNFSSGALASATPHFTPSHIQNGAHTNVDEDIDESMNEHWQQQLQLAAESRQASSPHYHARSVAQQAKGIQIAPSQPETQEQVPDGQNGVVKAKASSRQGWHALDFGGQGLRALSTSLFNYIFLEKLYLNHNKLKALPPAIGQLRKLNHLDLSGNDLTELPEEIGMLTNLKKLYLFDNNIRTLPYEMGYLYRLETLGVEGNPLNDVLKSHIMKEGTKALIKYLKEEMPAFFFSCTTPLTLMAVHLPPPDRDWIVLDETASSSNHRTDKVTVLSYNTLCDSSATQSHYGYAPARVLSWEFRRELILNELRSHDSDIICLQEIDQGSYNEYFREQLAYNDYKGVYWPRGRAMGMQEEDAKCVDGCATFFKGSKFILLDKQLINFGQTAVRRPDAKGQDDIYNRLWQKDHIAVVVFLENRQTGARFIVVNAHLYWDPAFKDVKLIQTAILMEELTKLSETYAKWPPCTDKAAFRFSKEEGQSETPPLEEPAPSMQYASGDQIPLLMCGDLNSSPGSAAYNLIAHGRLDEEHPDLEKRLYGNLSKVGMTHPFKLKSAYGAIGELPFTNYTPDFKDILDYIWYSSNSLHVSALLGEVDKDYLQRVPGFPNYHFPSDHIALLAEFTVKGKKGKVVEADFGPQRN
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).  Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
What are the official names of this protein?
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4, Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MDH_LEGPL
Sequence: MTNNRVRVAVTGAAGQIGYALVFRIASGQMFGPNTEVELNLLELEPALPSLEGVAMELDDCAFPLLKRIVCTADLNKAMDGVNWALLVGSVPRKQGMERSDLLQINGGIFTKQGQAINDYASDDVRVFVVGNPCNTNCLIAMNHAKDVPSDRFYAMTTLDELRARTQLAKKAGVDITAVTQMTIWGNHSATQYPDFYNAKINGTSAARVINDQTWLKETFVSTVQQRGAAVIKARGSSSAASAANAIITGVNHLVTDTPAGESFSMCRRSKGEYGVDEGLIFSFPCRREHGELKVVENMEFNDFGRERFNITLNELRSERDTVKSLGLLD
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: PP1R7_PONAB
Sequence: MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPEEEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKVTQLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLQELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTEPQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF
What is the function of this protein?
Regulatory subunit of protein phosphatase 1.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 7, Protein phosphatase 1 regulatory subunit 22.
What is the protein family that this protein belongs to?
Belongs to the SDS22 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1184_OCEIH
Sequence: MTHMHITSWALGLILFIIALVMYKKGNQKPAKIIHMILRLMFILIIITGGILTWDYIQGYGMPILGEALVKALAGLWLVAMMEMILTGKAKGKPTTAKWVQFSIALVLVIVLGFFRLPMGFLFI
What are the official names of this protein?
UPF0344 protein OB1184.
What is the protein family that this protein belongs to?
Belongs to the UPF0344 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIC1_HUMAN
Sequence: MYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRAFFAVLAAARLSIWYSRPSVLIVTYKEPAKSSTQFGSYKQAEWRPDSTMIAVSTANGYILFFHITSTRGDKYLYEPVYPKGSPQMKGTPHFKEEQCAPALNLEMRKILDLQAPIMSLQSVLEDLLVATSDGLLHLIHWEGMTNGRKAINLCTVPFSVDLQSSRVGSFLGFTDVHIRDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVVDGTCVAVNNKYRLMAFGCVSGSVQVYTIDNSTGAMLLSHKLELTAKQYPDIWNKTGAVKLMRWSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGFGSQNTEIESDLRSVVKQPSILLFQFIKSVLTVNPCMSNQEQVLLQGEDRLYLNCGEASQTQNPRSSSTHSEHKPSREKSPFADGGLESQGLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFMVLACYNINDRQEELRVYLRTSNLDNAFAHVTKAQAETLLLSVFQDMVIVFRADCSICLYSIERKSDGPNTTAGIQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARGAESIMLNLAGQLIMMQRDRSGPQIREKDSNPNNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYTRNNAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTAQEPSSSGGFEFFRNRSISLSQSAENVPASKFSLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEDVRLKDLGCFAAQLGFELISWLCKERTRAARVDNFVIALKRLHKDFLWPLPIIPASSISSPFKNGKYRTVGEQLLKSQSADPFLNLEMDAGISNIQRSQSWLSNIGPTHHEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDLTESSSMVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVITQSSEVDGEMLQNIKTGLHAVDRWASTDCPGYKPFLNIIKPQLQKLSEITEEQVQPDAFQPITMGKTPEQTSPRAEESRGSSSHGSIPQGEVGSSNMVSRKEEDTAQAEEEEPFQDGTYDCSVS
What is the function of this protein?
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056).  The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056).  Required for phosphorylation and localization of GJA1 (PubMed:16112082).  Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796).
What are the official names of this protein?
Guanine nucleotide exchange factor subunit RIC1, Connexin-43-interacting protein of 150 kDa, Protein RIC1 homolog, RAB6A-GEF complex partner protein 1.
What is the protein family that this protein belongs to?
Belongs to the RIC1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane.
Protein: SAES_STAAE
Sequence: MVLSIRSQIIIGVVSSIPLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
What is the function of this protein?
Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion.  Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR.  SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (hla, hlb, hlgC), coa, DNase, spa and cell wall-associated proteins (emp, eap, fnbA, fnbB, efb).  Represses the expression of type 5 capsular polysaccharide (cap operon).  Also modulates the expression of several other genes.
What are the official names of this protein?
Histidine protein kinase SaeS, Sensor protein SaeS, Staphylococcus exoprotein expression protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL10_RAT
Sequence: MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS
What is the function of this protein?
Component of the large ribosomal subunit.  Plays a role in the formation of actively translating ribosomes.  May play a role in the embryonic brain development.
What are the official names of this protein?
60S ribosomal protein L10, Ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.