PharMolix/UniProtQA huggingface dataset:
Protein: IL31_HUMAN
Sequence: MASHSGPSTSVLFLFCCLGGWLASHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
What is the function of this protein?
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896).  May function in skin immunity (PubMed:15184896).  Enhances myeloid progenitor cell survival in vitro (By similarity).  Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
What are the official names of this protein?
Interleukin-31, IL-31.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2661_YERPY
Sequence: MDHRLLEIVACPVCNGKLYFNKENLELVCKVDNLAYPVRDGIPVLLENEARPLSIDEKHA
What are the official names of this protein?
UPF0434 protein YPK_2661.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: RL29_FRAP2
Sequence: MKRKDTLKDFRGKSIDQLQEAKIELLQQLFSLRMQKGTGQLKKNHLFKSAKRDIARINTIISEKNK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: RSMH_CHLPN
Sequence: MSERAHIPVLVEECLALFAQRPPQTFRDVTLGAGGHAYAFLEAYPSLTCYDGSDRDLQALAIAEKRLETFQDRVSFSHASFEDLANQPTPRLYDGVLADLGVSSMQLDTLSRGFSFQGEKEELDMRMDQTQELSASDVLNSLKEEELGRIFREYGEEPQWKSAAKAVVHFRKHKKILSIQDVKEALLGVFPHYRFHRKIHPLTLIFQALRVYVNGEDRQLKSLLTSAISWLAPQGRLVIISFCSSEDRPVKWFFKEAEASGLGKVITKKVIQPTYQEVRRNPRSRSAKLRCFEKASQ
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURZ_BPPMB
Sequence: MNSNKKATIVVDAQFGSTGKGLIAGYLAERDQPDVVMTAWSANAGHTYINAEGRKFVHCMLANGIVSPKLTTVLIGPGSQMNAELLRDEILSCADLLQGKTILLHASAALILQKHVEEEAGPMTKIGSTKKGCGAAMIAKIRRNPDDNNTVGANGDYMEEHIYGPVREAGVFIRTATNAEYMAVVYDAERIQVEGAQGFSLGINNGFYPYVTSRECTPAQVAVDVNLPLAFIDKVVACMRTLPIRVANRYNDKGEQIGWSGPCYPDQKELDWEKDLGMEAELTTVTKLPRRIFTFSYEQTKAALEVIRPDEVFLNFCNYLEPDEVAAVIGTIERAAHELKVPGPMPLARYYGYGPTVNDIDLDMRHQ
What is the function of this protein?
Involved in the synthesis of the atypical nucleotide dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate).  Catalyzes the condensation of aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation respectively by host PurB and guanylate/nucleoside diphosphate kinases to give dZTP.  dZTP is integrated into the viral genome instead of adenine by the viral DNA polymerase.  This Z-base probably completely replaces adenosine and forms a triple bond to the opposite T-base.  The resulting non-standard viral DNA is called Z-genome.  The chemically modified DNA is probably harder for the host bacteria to digest with nucleases or restriction enzymes.
What are the official names of this protein?
N6-succino-2-amino-2'-deoxyadenylate synthase, 2-amino-2'-deoxyadenylo-succinate synthase, PurZ.
What is the protein family that this protein belongs to?
Belongs to the Caudovirales PurZ family.
Protein: AL8A1_MOUSE
Sequence: MAGKRELLMLENFIGGKFLPCNSYIDSYDPSTGEVYCKVPNSGKEEIEAAVEAAREAFPAWSSRSPQERSLVLNRLADVLEQSLEELAQAESKDQGKTLTLARTMDIPRSVLNFRFFASSNLHHVSECTQMSHLGCMHYTVRTPVGIAGLISPWNLPLYLLTWKIAPAIAAGNTVIAKPSEMTSVTAWMFCKLLDKAGVPPGVINIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLEECIPATVRSSFANQGEICLCTSRIFVQRSIYSEFLKRFVEATRKWKVGVPSDPSANMGALISKAHLEKVRSYVLKAQTEGARILCGEGVDQLSLPLRNQAGYFMLPTVITDIKDESRCMTEEIFGPVTCVVPFDSEEEVITRANSVRYGLAATVWSKDVGRIHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITIKY
What is the function of this protein?
Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.
What are the official names of this protein?
2-aminomuconic semialdehyde dehydrogenase, Aldehyde dehydrogenase family 8 member A1, Retinal dehydrogenase 4.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: LGT_STAAN
Sequence: MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTNA_THEP3
Sequence: MKEIKSIEFKNEVLYLIDQRKLPNSYEIFECKTYRDVNFAIKEMVVRGAPAIGAAAAYGVVLAAKEFLKEDREIFFEKIEEALEVIANSRPTAVNLMWAVKRMKKVIEKNKELELIDIYQALKKEADSIYLEDIETNKKMAKFGNEVIKENAVILTHCNTGALATVGYGTALGVIREAHYSGKNIFVYADETRPRLQGSKLTAWELVQEGIPAKLIADSVAATLIRDGKIDVILVGADRIALNGDTANKIGTFMLSVIAKVYNVPFYVVAPTSTIDFEIESGKEIIIEERSPEEVTHINGVRIAPEGIEVYNPAFDVTPHENITGIITEKGIIKPPYKENILKLK
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: DNAT_ECOL6
Sequence: MSSRVLTPDVVGIDALVHDHQTVLAKAEGGVVAVFDNNAPAFYAVTPARLAELLALEEKLARPGSDVALDDQLYQEPQTAPVAVPMGKFAMYPDWQPDADFIRLAALWGVALREPVTAEELASFIAYWQAEGKVFHHVQWQQKLARSLQIGRASNGGLPKRDVNTVSEPDSQIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: AATNT_GEOSL
Sequence: MDVITTHVNADFDCLGAMVAASKLYPDALMVFSGSQEKSMRDLFLKTTGYALPFTRLRDVDFSDITRLVLVDCQHTSRIGRFAEVARRPGVEVHIYDHHPGSSGDIRPSGGEIRDCGSSTTILTRKLMEQGIEVTAVEATLMMLGIYEDTGNLTFPSTTPEDYAAASWLLERGANLNIVSDFVSQELTAEQVALLNDLLKSLRSTPVNGVDIAVAHATLDHYVGDIAVLAHMMRDMQNLDAIFLVVGMGERVYLVARSRIAEVDAGAVMRVFGGGGHATAAAATVRDQTVIQVLGRLNRLLPELVNPVRTAADLMSSPVITLPLATTITEAREILTRYNVNAMPVMDGERMAGIISRRIVEKALYHGLGNLPVDEYMHTEFLRAAPDTPINAIQDYIVGQHRRLVPVFSGERLVGVITRTDLLRYMYTGTQRNAEPVYDLGSENLPVRRREVVHLMNRHLPRPTVAMLRDLGKVGDELELPVYAVGGFVRDLLLGAENDDIDVSVEGDGILFAETVANRVGCRVKSHAKFGTAVIVFPDGLKVDVASTRLEYYETPGALPTVERSSLKMDLYRRDFTINTLAVKLNAEGFGTLIDYFGAYRDLQEKTIRVLHNLSFVEDPTRVFRAIRFEQRLGFPISRHTENLIKNAVKMGFLDKLGGRRLLNELVLILREREPVKAILRMSGLGLLRFIHPDLVLAPNTLQVLDEVKKVITWFDLLYLGEKVETWVVYFLALTSSLPDEGFWGTCTRLSVSEHYREKLIDMRVHGEQVLEVMTRKAARREDVRRSDIYFWLRGLSPEVLLYIMAKTRSDEVRRYVSLYVTQLRGIVTHITGDDLKTLGIPSGPRYREILDRVLTARLNGEAATRDDEMRIAVRLADSA
What is the function of this protein?
tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus.  Adds the terminal adenosine residue to tRNA.
What are the official names of this protein?
A-adding tRNA nucleotidyltransferase, A-adding TNT, A-adding enzyme, NTSFIII.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Protein: Y2797_PHOPR
Sequence: MTQRTVWQDFQNGQQYMATWPMRKELAAIFPEQRYIKATKFATRVMPAVAVMSVLSQMAFNNYGALPQAMTVALFALTMPLQGLWWLGKRSRTTLPPSLAIWYREIYEKITSEGHAMQPLKKQPRYLELAEVLNRAFKQLDKTSLERWF
What are the official names of this protein?
UPF0208 membrane protein PBPRA2797.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSDH_ORYSJ
Sequence: MAMAMAMRRAAALGARHILAASSTSSSGVLLRRHMSVDAGAAMEKVRAAGLLRTQGLIGGKWVDAYDGKTIEVQNPATGETLANVSCMGSKETSDAIASAHSTFYSWSKLTANERSKALRKWHDLIISHKEELALLMTLEQGKPMKEALVEVTYGASFIEYFAEEAKRIYGDIIPPTLSDRRLLVLKQPVGVVGAVTPWNFPLAMITRKVGPALACGCTVVVKPSEFTPLTALAAADLALQAGIPAGAINVVMGNAPEIGDALLQSTQVRKITFTGSTAVGKKLMAGSANTVKKVSLELGGNAPCIVFDDADIDVAIKGSLAAKFRNSGQTCVCANRILVQEGIYEKFASAFIKAVQSLKVGNGLEESTSQGPLINEAAVQKVEKFINDATSKGANIMLGGKRHSLGMSFYEPTVVGNVSNDMLLFREEVFGPVAPLVPFKTEEDAIRMANDTNAGLAAYIFTKSIPRSWRVSEALEYGLVGVNEGIISTEVAPFGGVKQSGLGREGSKYGMDEYLELKYICMGNLN
What is the function of this protein?
Oxidizes specifically succinate semialdehyde.  Involved in plant response to environmental stress by preventing the accumulation of reactive oxygen species (By similarity).
What are the official names of this protein?
Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member F1, NAD(+)-dependent succinic semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: TRUD_SALPC
Sequence: MTEFDNLTWLHGKPQGSGLLKANPEDFVVVEDLGFTPDGEGEHILLRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDFSAFQLEGCKVLEYARHKRKLRLGALKGNAFTLVLREISDRRDVETRLQAIRDGGVPNYFGAQRFGIGGSNLQGALRWAQSNAPVRDRNKRSFWLSAARSALFNQIVHQRLKKPDFNQVVDGDALQLAGRGSWFVATSEELPELQRRVDEKELMITASLPGSGEWGTQRAALAFEQDAIAQETVLQSLLLREKVEASRRAMLLYPQQLSWNWWDDVTVELRFWLPAGSFATSVVRELINTMGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: TRHO_STRZJ
Sequence: MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADEGINGTVSGDYETTQKYMDYVHSLPGMEELWFKIDEENEQAFKKMFVRYKKEIVHLGLEDNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: TRPF_BACSU
Sequence: MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDVKKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCEIWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKRCFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RLMN_HALHL
Sequence: MHAERRSGPVELLGLDRPRLAAFFDTLGEKRFRARQIMQWLHQRHVYDFDEMTDLSKALRQRLREHARVGLPEVAADQQASDGTRKWVVRLADGNCVEAVYIPEPKRGTLCISSQAGCPMGCTFCATGEGGFSRNLTAAEIVGQVHVARQHLPEGAITNIVFMGMGEPLLNFDPVISASRVFTDDYGFVLSKRRVTISTSGVVHAIERMQRVTDVSLAVSLHAPNNELRNQLVPLNRKNPLERLLPACHAYIAEKPHRRITWEYVMLDGVNDQDEHARELLQRLRGIPSKVNLIPFNPYPGARYGRTPDRQVRRFADRLLEHGLTATIRETRGDDIDGACGQLVGEIRDARASKVARPA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_METST
Sequence: MAEKDKWGVAHVYSSFNNTIITVTDITGAETITQWSGGKVVRSDRQESSPFAAMEAANRVADDIKEKGIAGLHIKVRASGGNGPRTPGPGAQATIRALARAGIKIGKIEDVTPIPHDGTGRPGGKRGRRV
What is the function of this protein?
Located on the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: TIM8_YEAST
Sequence: MSSLSTSDLASLDDTSKKEIATFLEGENSKQKVQMSIHQFTNICFKKCVESVNDSNLSSQEEQCLSNCVNRFLDTNIRIVNGLQNTR
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.  The TIM8-TIM13 complex is non essential and only mediates the import of few proteins under precise conditions, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.  Strictly required for import of TIM23 in some conditions, when a low membrane potential exists in the mitochondria.
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM8.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion intermembrane space. Note=Import into inner membrane protein requires TIM5 function.
Protein: RL25_BEII9
Sequence: MAERKTLAATVRGGTGKGAARSIRREGRIPGVIYGGGDAPEPITLDYRELNKLIYAGHFLTTIFDIEVEGAKQRVVPRDYQLDPVKGQPLHVDFLRLKPGATLKVSVPIHFINADICPGLKKGGTLNIVRHAIELKVPADAMPDVLTADLHALEIAESMHVSAITLPEGCSLVATDRDFTIATIVPPVVIAEEAPAAAAGKGKGGKGKAAAPAAAAAPKKK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: WDR72_HUMAN
Sequence: MRTSLQAVALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAENGEMCVWNVTNGQCMEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAGELKVWDLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYDYCDFSLLLTEVSRNGQFFAGGEVIAAHRILIWTEDGHSYIYQLLNSGLSKSIYPADGRVLKETIYPHLLCSTSVQENKEQSRPFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPVSKFDGSPREIPVTATWTLQDNFDKHDTMSQSIIDYFSGLKDGAGTAVVTSSEYIPSLDKLICGCEDGTIIITQALNAAKARLLEGGSLVKDSPPHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARIILNCCDDSQLVKSVLPIASETLKHKSIEQRSSSPYQLGPLPCPGLQVESSCKVTDAKFCPRPFNVLPVKTKWSNVGFHILLFDLENLVELLLPTPLSDVDSSSSFYGGEVLRRAKSTVEKKTLTLRKSKTACGPLSAEALAKPITESLAQGDNTIKFSEENDGIKRQKKMKISKKMQPKPSRKVDASLTIDTAKLFLSCLLPWGVDKDLDYLCIKHLNILKLQGPISLGISLNEDNFSLMLPGWDLCNSGMIKDYSGVNLFSRKVLDLSDKYTATLPNQVGIPRGLENNCDSLRESDTIVYLLSRLFLVNKLVNMPLELACRVGSSFRMESIHNKMRGAGNDILNMSSFYSCLRNGKNESHVPEADLSLLKLISCWRDQSVQVTEAIQAVLLAEVQQHMKSLGKIPVNSQPVSMAENGNCEMKQMLPKLEWTEELELQCVRNTLPLQTPVSPVKHDSNSNSANFQDVEDMPDRCALEESESPGEPRHHSWIAKVCPCKVS
What is the function of this protein?
Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349).  Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins.  May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.
What are the official names of this protein?
WD repeat-containing protein 72.
What are the subcellular locations of this protein?
Cytoplasmic vesicle.
Protein: RL16_LISMF
Sequence: MLVPKRVKYRREFRGNMRGRAKGGTEVAFGEYGLQAVEASWITNRQIEAARIAMTRYMKRGGKVWIKIFPHKSYTSKPIGVRMGKGKGAPEGWVSPVKRGKIMFEIAGVPEDVAREALRLAAHKLPVKTKIVKREEIGGEANES
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RSMJ_SHEB9
Sequence: MTPIFFNQQYPTLVDICARWQLVYDANATFELRFESDTLSLHKRDEPKLDGIVVDFVTGAVAHRRKFGGGRGQSIAKAVGLKQGVMPSVVDGTAGLGRDAFVLASLGCTVTMVERHPVVAALLEDGLRRAYQDAEIGDWMRERMRLFHGSSLEALSKLAQEVDVVYLDPMYPHRDKSALVKKEMRVFQSLVGADLDADGLLAPALALATKRVVVKRPDYAEDLDGVKPNTVIETKKNRFDVYVKAAMK
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM61_YARLI
Sequence: MFSAYKDTIEDGDLVLGWMTRTAIKPIVVEKKEGLFNTRYGAFPHRNMDKYGAQLGSMSKQGFIHLIHPTPELWTLSLPHRTQIVYTTDSSYIVQRLKIRPGSTVIESGTGSGSFTHAISRSAGLAGKVYSYEFHEERYNLAKQEFERHQLTNVIPTHRDVCNDGFDIENIDVNATAVFLDLPAPWTAIPHLERVIDRSVVSRVCCFSPCFEQVVKAVQALQEAGWVDIEMVEVAAKRWESRLEMKRSLDEAITRLRDVKARRETGLAKRNARIKVETETGVEEEESDERDAKRSKTESGHRGYNPWGKGQKIKEGDESFEWTEVSKCEQEIKSHTSYLLFASRLPKLGEEVFDKDMCVRPYSERCPETSTEGAEASTEATEAPARTEA
What is the function of this protein?
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
What are the official names of this protein?
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, tRNA(m1A58)-methyltransferase subunit TRM61, tRNA(m1A58)MTase subunit TRM61.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTNA_EXIS2
Sequence: MSQFVQSIIYENRTVTILDQTRLPEEEHYEIIHDLAQAIDAIKQLRVRGAPAISLFGGFVLVQEAFRTTGTLAEAKQELLEVSAQLLATRPTAVNLRNVLDELNQLIVSATTLKELPVRLEQKALELYQTDAKTSRQIGVHALELFESGDRVLTICNAGSIATAAYGTALAPFYLAKEQGIPLSVYASETRPLLQGARLTTWELQRAGIDVTLITDNMVAHTIKEKQITAIIVGADRITRNGDTANKIGTFQLALLARAFGIPFYVAAPLSTFDFTSLSGDEIEIEERDAREVTQLAGKATAPAGVPVFNPAFDVTPHDLITAIITELGVIEHPDVETIKRTIGQHTH
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: DNAC_SHIFL
Sequence: MKNVGDLMQRLQKMMPAHIKPAFKTGEELLAWQKEQGAIRSAALERENRAMKMQRTFNRSGIRPLHQNCSFENYRVECEGQMNALSKARQYVEEFDGNIASFIFSGKPGTGKNHLAAAICNELLLRGKSVLIITVADIMSAMKDTFRNSGTSEEQLLNDLSNVDLLVIDEIGVQTESKYEKVIINQIVDRRSSSKRPTGMLTNSNMEEMTKLLGERVMDRMRLGNSLWVIFNWDSYRSRVTGKEY
What is the function of this protein?
This protein is required for chromosomal replication.  It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity).
What are the official names of this protein?
DNA replication protein DnaC.
What is the protein family that this protein belongs to?
Belongs to the DnaC family.
Protein: GCH1_MANSM
Sequence: MSRISAEAEKVRHALIEKGIETPMIALTKSKNERRIGIENRMREVMQLIGLDLTDDSLEETPVRLAKMFIDEIFSGLDYTNFPKITNIENRMKVSEMVLVNDVTLTSTCEHHFVTIDGLVSVAYYPKKWVIGLSKINRVVQFFAQRPQVQERLTEQILLAFQTILETEDVAVYMKATHFCVKCRGIKDTNSYTVTSAFGGVFLEDRETRKEFLSLINK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: PSF1_CRYNJ
Sequence: MYGDLALQLVNSSHRTTLSSTPQLPLPKYALPLILSICLETRQLGTSIASIAESHGQLSLTQDRGLVCNLTVQHLAARRNKRCMLAYLATRVGGIKERWWDAGGGLAYLLSPAASASVNPEADAPDLRSALSPQELDFLRGYNNLLLDYKSDFLDVLDLTAGIEKPPGEIMVDVRVVRDAGEVFLDSGERVDFRKGQRFRLERAQVERLIIQGYLEEV
What is the function of this protein?
The GINS complex plays an essential role in the initiation of DNA replication.
What are the official names of this protein?
DNA replication complex GINS protein PSF1.
What is the protein family that this protein belongs to?
Belongs to the GINS1/PSF1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FCG3A_CERAT
Sequence: MWQLLLPTALLLLVSAGMRAEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTRWFHNESLISSQTSSYFIAAARVNNSGEYRCQTSLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDSIHLRCHSWKNTLLHKVTYLQNGKGRKYFHQNSDFYIPKATLKDSGSYFCRGLIGSKNVSSETVNITITQDLAVSSISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKKSIPSSTSDWKDHKFKWSKDPQDK
What is the function of this protein?
Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG).  Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC).  Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity).  Mediates IgG effector functions on natural killer (NK) cells.  Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation.  Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC.  Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity).  Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes.  Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation.  The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (By similarity).  Costimulates NK cells and trigger lysis of target cells independently of IgG binding.  Mediates the antitumor activities of therapeutic antibodies.  Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity).  Mediates enhanced ADCC in response to afucosylated IgGs (By similarity).
What are the official names of this protein?
Low affinity immunoglobulin gamma Fc region receptor III-A, IgG Fc receptor III-A, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcgammaRIIIa.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Secreted. Note=Exists also as a soluble receptor.