PharMolix/UniProtQA huggingface dataset:
Protein: ACE3_MOUSE
Sequence: MNLPWALLLVLLSHRQLLPWLRTVGETSLNDFYSEAQAKLFLQFYEQTAQVVLNEFMEATWNYVTNITKQNQKNMLQKEADRSQFMLYFSTRARMFRTDHFLNQDVKRMLRKLQNIDKSALPTEDLLEYNRLLTYMETAYNRAEVCLDEGPCLTLEPDLQEIMATSRDQKELLWAWQGWRDAVGRQLRPVFEDYVRLSNKAAQYNGYKDMGALWRSKYESDTLEEDLEQLYKELQPLYLNLHAYVRRSLYRYYGPELIDLRGPIPAHLLGNMWAQSWNNILDLVLPYPTKAPEDITAIMKIQHWRPEKMFEEANLFFTSMGMLPAPPAFWIKSMMEKPADGREVECHTSSWNFYKFNDFRVKKCTEVTLEDLLSVFHQMGHIQYFLQYQNLSVIYQEGASPAFEEAVGSVIALSVSSHKYLLARGLLSQPHQDSEEEVNFLLGIALEKIAFIPFSYLVDKFRWKIFDGTISKITYNQEWWNFRLKYQGLCPPVPRSDDDFDPGAKFHIPANVPYIRYFLGLILQFQLHEALCEASGHVGPLHQCDNYNSKVAGKILGDLLKLGSSRPWREVLQEVTGESNISTKAFLTYFKPLMDWLVTENVKQGDTLGWPDFSCSFEEKITSKVSFLGTDTEPEQAYLGQWVLLSMSFFMLVLILALGFRLHYLEKQLLDEDTMILKTLPYSYFLGIAMEPHQAARKQWLLLGLCCILMLCCIGLLIRIVTQNTENTPWMKNEGQS
What are the official names of this protein?
Angiotensin-converting enzyme-like protein Ace3.
What is the protein family that this protein belongs to?
Belongs to the peptidase M2 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Multi-pass membrane protein. Note=Disappears from acrosome reacted sperm. Co- localizes with IZUMO1 at acrosomal cap area.
Protein: GCH1_CHESB
Sequence: MDAIIKSFPPRPDQTSVPAEQAGYLDKPITDRPSREEAEAAVRTLLRWAGDNPDREGLKETPARVVKAYQELFGGYDLCPAEELGRTFEEVAGYEDMVLVKDIPFHSHCEHHMVPIVGKAHVGYLPDGKVVGLSKIARVVDIFARRLQTQEAITAQIAGAIQNVLQPLGVAVMVEAEHMCMAMRGVRKQGASTLTTTFTGAFKTRPEDQARFITMVRDSRSG
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: GCSP_FLAJ1
Sequence: MKTDAFALRHIGPRETDLQHMLQTIGVDSIEQLVYETLPDDIRLKAPLNLDPAMTEYEFANHIQELGKKNKVFKSYIGLGYHPTIVPAPIQRNIFENPGWYTAYTPYQAEIAQGRLEAILNFQTTVIELTGMEIANASLLDEGTAAAEAMALLFDVRTRDQKKNNTHKFFVSEEILPQTLSVLQTRSTPIGIELVVGNHETFDFSTEFFGAILQYPGKYGQVNDYGAFVAKAKENEIKVAFAADILSLAALTSPGEMGAAVVVGTTQRFGVPMGYGGPHAAYFATKDEYKRSMPGRIIGVSVDANGNRALRMALGTREQHIKREKATSNICTAQVLLAVMAGMYAVYHGPKGLKYIANKVHASAVTTAEALNKLGVFQTNTAFFDTILVKADAQKVKAIAEKNEVNFFYPDAESVSISLNETTSVSDINQIIAIFAEALGKEAVTVSELTTASQLPASLERTSSFLTHDVFNNHHSESQLMRYIKKLERKDLSLNHSMISLGSCTMKLNAASEMLPLSMPNWNSIHPFAPVEQAEGYITMLKKLEQQLNVITGFAGTTLQPNSGAQGEYAGLMAIRAYHLSRNEGHRNVCLIPSSAHGTNPASAAMAGMKIIVTKTTPEGNIDVEDLREKAIEHKDDLSCLMVTYPSTHGVFESSIIEITKLIHENGGLVYMDGANMNAQVGLTNPATIGADVCHLNLHKTFAIPHGGGGPGVGPICVNEKLVPFLPTNPILKVGGEQAITAISSAPYGSALVCLISYGYITMMGAEGLKSATEHAILNANYMKSRFEGHYPILYTGECGRAAHEMILDCRAFKENGIEVGDIAKRLMDYGFHAPTVSFPVAGTLMIEPTESEDLAELDRFCDALISIRKEIEAATADDKNNVLKNAPHTLAMLTSDSWDFPYSREKAAYPLEYIADNKFWPSVRRVDDAYGDRNLVCSCAPIEAYMEN
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: GCSPB_THISH
Sequence: MLIFERSRPGRGATAQAPLREATVSGLPERFRRGTRAPLPELSELDVVRHYTRLSQKNFSIDTQFYPLGSCTMKYNPRACNSLAMLPGFLGRHPHAPDTHSQGFLACMFELQEMLRDVTGMKGGVSLTPMAGAQGEFAGVAMIRAYHDARKDTARTEILVPDAAHGTNPATATMCGYTVKEIPTDDSGDVDMEALKAALGPHTAGIMLTNPSTLGVFERRIKEIADLVHQAGGLLYYDGANLNAILGKVRPGDMGFDVIHMNLHKTFSTPHGGGGPGAGAVGVSERLRPFMPIPVVAKEGERYRFMTEKDLPQSIGRLSAFAGNAGVLLRAYVYMRMLGRAGMPRVAEFSTLNANYVMARLREKGFELAFPGRRATHEFIVTLKRLAKDTEVTAMDVAKRLLDFNYHAPTTYFPLLVPECLLIEPTETESKETLDGFVEAMAEILEEARTSPDKVKGAPYTQPNRRFDEVRAARELDVAWRPGAALDEVAEQGRTD
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: MAT2B_RAT
Sequence: MVGREKELSIHFVPGCCQLVEEEVNIPSRRVLITGATGLLGRAVYKEFQQSNWHAVGCGFRRARPKFEQVNLLDSEAVHHLIHDFQPHVIVHCAAERRPDVVESQPDAASQLNVGASGNLAKEAAAIGAFLIYISSDYVFDGTNPPYTEEDIPSPLNLYGKTKLDGEKAVLENNLGAAVLRIPVLYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVASVCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVIGAQRPKNAQLDCSKLETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
What is the function of this protein?
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP.  Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.  Can bind NADP (in vitro).
What are the official names of this protein?
Methionine adenosyltransferase 2 subunit beta, Methionine adenosyltransferase II beta, MAT II beta.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
Protein: TC32B_BRANA
Sequence: MEIYGMVTGKAGKSGYGSASTAEDVTHSIDAKHLTAIITGGTSGIGLEAARVLGMRGAHVIIAARNTKAANDSKEMILQMYPNARIDCLQLDLSSIKSVRSFIHQFLALNVPLNILINNAGVMFCPFQLSEDGIESQFATNHIGHFLLTNLLLDKMKSSARESGIEGRIVNLSSIAHTYTYTEGIMFDYINDPDRYSEKKAYGQSKLANLLHSNALSRKLQEEGVNITINSVHPGLITTNLFRHSGLGMAVLKAMSFFLWKNIPQGAATTCYVALHPDLKGVTGKYFTDCNVTTPSNFAIDTTLADKLWDFSIKLVDSLP
What is the function of this protein?
Involved in protein precursor import into chloroplasts.
What are the official names of this protein?
Short-chain dehydrogenase TIC 32 B, chloroplastic, Translocon at the inner envelope membrane of chloroplasts 32 B, BnTIC32B.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane.
Protein: UVRC_ALIF1
Sequence: MPSFDSKAFLKSVTHQPGVYRMYNAEADVIYVGKAKDLKKRLSSYFRSNVPSEKTKALVSHIHQVDVTVTHSETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFISQHKHPRISIHRGVKRKKGEYFGPYPDSGAVRESLHLIQKLFPIRQCEDSVYANRHRPCLMHQIGRCLAPCVKGIVSDEEYKEQTDFIRLFLQGKDRQVIQTLVKQMESASQSLNFEKAAIIRDQIQAMRRVQEQQYVSDDSGDDLDVLGFAIENGLACVHLLMIRQGKILGSRSFFPKIPANTDKEEVFLSFLTQYYLNHTQGRTIPNRVVTSFEFNSEDLERALTELSGRKVIFQLNPKGIKGRYLKLADTNALTALTSKSNHKLTMYQRFKQLEEALVLSSIQRMECFDISHTMGEKTVASCVVFNQEGPVKSEYRRYNIAGITGGDDYAAMAQVLERRYSKQLDIDKIPDIIFIDGGKGQLNRAYEVISKHWEDWPKQPLLLGIAKGVTRKHGLETLVKISGEEFSMPSDSPALHLIQHIRDESHNHAIGGHRAQRAKVRKTSTLQNIDGVGPKRRQALLQYLGGLQELKSASVEEIAKVPGISHSLAEKIHDALKHG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_STAEQ
Sequence: MERTFLMIKPDAVQRNLIGEIISRIEKKGLKLVGGKFMQVPMELAEKHYSEHEGKPFYDKLISFITSAPVFAMVVEGENAVAVSRKIIGSTNPSEAAPGTIRGDYGLNLGRNIIHGSDSTESAQREVKLWFTSSEIADYKEPREDWLYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_BORA1
Sequence: MLQPSRRKYRKEQKGRNTGLATRGAQVSFGEFGLKATGRGRLTARQIEAARRAINRHIKRGGRIWIRIFPDKPISQKPAEVRMGNGKGNPEYWVAEIQPGKVLYEMEGVSEELAREAFRLAAAKLPISTTFVARHIGA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: HPRK_BACC7
Sequence: MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSEQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue.  Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: SCXB_BUTOC
Sequence: LKDGYIVDDRNCTYFCGTNAYCNEECVKLKGESGYCQWVGRYGNACWCYKLPDHVRTVQAGRCRS
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Alpha-toxin Bot11, BotXI, Neurotoxin 11, Toxin XI.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TONSL_BOVIN
Sequence: MSLERELRQLSKAKTKAQRSGQLREEASVCHQLGELLASHGCYAEALREHQQELQLLETTDDPLGCAVAHRKIGERLAEMEDYSAALQHQHRYLELACALSNHVEQQRAWATIGRTHLDIYDHHQSQDALQQAQDAFEKSLAILDEKLQGSLPKRELSEMRTRIYLNLGLTCESLQQVALCSAYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRRGQHSQAMRCLEGARECARVLKQAFLESECCLLLSQVLLDLGDFLAAKRALKKAYRLGSQKPLQKASVCRTLKYVLAVVQLQQRLEESEESDPEVAMGICEQLGDLFSKAGDFPKAAAAYQKQLRFAELLSRPGPELAVIHVSLAATLGDMKDHRQAVHHYEAELKLQEGNPLEEAKTWLNIALSREEAGDAYEVLALCFQKALGCAQLAGQPQLQRQILQHLHAVQLRLQPQEAPSTETRLQELKAAGDEDEGDGEDEEDEEDDDALEATELELSESENEADASPPLEEDEELRGCLGRQRVNKWSRRNDVGETLLHRACIEGQLGRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLDIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTLRTRKGHNPLETLQQWVKLYGKDLDSETQEKAAAMGRLLQAASLGRAPHSSQAPQTLPSNHLFDPETSPPSSPCPGTPEVCEASTRVSQGLAVSTVARPRRSRHKVASSSSSEGEDSAGPSQPTQKRPRHASPSLQTKAPMPGPASDREAATTSTSWAAYREAIRGVGSAQTCRLGPSPLRGPSEIPIPQAALIPQEECLAGDWLEEDFPMSPGHRGRCPARPQSSGDGGRHRASGPGSDTARRPRAQARQSRLPYLESWSTPVRADRANSQATEPARSPDVPRVVAPTGENPTTGHLPGQVLPPPIRVRVRVQDNLFLIPVPHREAHSVAWLAEQAAQRHYQASGLLPRLSLQKEGALLAPQDPIPDVLQSNEEVLAEVTSWDLPPLRDRYRRACQTLEQGEHQQVLQAVEHQGSAPTFSACSLALRQAQLTPLLRALKLHSALRELRLAGNRLGDGCVAELLATLDTVPGLTLLDLSSNHLGPEGLRQLAAGLLGQTTLQNLEELDLSMNPLGDGCGQALASILRACPVLCTLHLQACGFGPGFFLSHQVALGSAFQDTKCLKTLSLSYNGLGPTALGPVLGSLPAHSLLRLELSSVVTGKSDVGLTDPVVHYLSQEGCVLEHLSLSANHLGDKDVRALSRCLPLCPSLVSLDLSANPEVSSAGLEELLSTLQKRPQGLSFLGLSGCAVQGPLGLDLWDKVVAQLQELQLCTRRLSAEDRNALHQLLPSQLGPKVCTLDQGPKLFFRHL
What is the function of this protein?
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks.  The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication.  It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs.  Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination.  Within the complex, TONSL acts as histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones.  Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3. 1.
What are the official names of this protein?
Tonsoku-like protein, Inhibitor of kappa B-related protein, I-kappa-B-related protein, IkappaBR, NF-kappa-B inhibitor-like protein 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2.
What is the protein family that this protein belongs to?
Belongs to the Tonsoku family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks. Recruited to stalled or collapsed replication forks following histone replacement by histone chaperones ASF1A and the CAF-1 complex: TONSL acts as histone reader that recognizes and binds newly synthesized histones.
Protein: RPO1C_SULIA
Sequence: MIDEKDKSYLEEKVKQASNILPQKIVEDLKNLISNKEVLVTRDEIDKIFDLAIKEYSEGLIAPGEAIGIVAAQSVGEPGTQMTLRTFHFAGIRELNVTLGLPRLIEIVDAKKVPSTPMMTIYLTDEYKHDKEKALEVARKLEYTKIENVVSSTSIDIASMSIILQLDNEMLKDKGVTVDDVKKAINRLKLGEFVIDESEGNTLNISFANIDSIAALFKLRDKILNTKIKGIKGIKRAIVQKKGDEYIILTDGSNLSGVLSVKGVDIAKVETNNIREIEEVFGIEAAREIIIREISKVLAEQGLDVDMRHILLVADVMTRTGVVRQIGRHGVTGEKNSVLARAAFEVTVKHLLDAAARGDVEEFKGVVENIIIGHPIKLGTGMVELTMRPILR
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ4_LEIIN
Sequence: MKNCMMADQRGRSILKHQPVVGDEALEFSRGLAPSTFGFRYAAYMDRNHFLPSGRTAVKHIADPTLAYVMTRYRQCHDFVHIITGCGRSIEEELAVKIFEWKHTGLPLGLLSLLGGAPRLAAAQWAHMRLYWEWASRNAPCSRHGEPAVPMYLNVPWEDMLAKEYDEVVAYTGITPLPQFLEKRQQH
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial, Coenzyme Q biosynthesis protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: PATE_ASPCL
Sequence: MRPIPSILGALGAFATLSAAAPLESTLYGPGASHARSMLGSSFGVPGNQTFDYVVIGGGTAGLAIASRLAEQGAGTVAVIEAGGFYELNNGNLSQIPANDAYYVGKDLDDWQPGVDWGFHTVPQAGAYGRASHYARGKCLGGSSARNYMAYQRGTKSSYQRWADMVGDQSYAWENFLPFFEKSLHFTPANDALRGANATVQYDPAVLGNGQGPLSVTYSHYVQSFATWAQKAFLEMGLAVRNCFQSGELLGQSFGMYTINATTMHRESSETSFLRRALAYPNFMVFQSTLAKRILFDGKKRAVAVQLDTQGYRYTLTARKEVVLSAGAFQSPQLLMVSGVGPAATLQQHGIPLVADRPGVGQNLQDHIIYAPSYRVDLITQSALLNATFEAQANRDYHERAAGIYANPTSDILAWEKIPEPKRSAWLSNTTRRALAQYPADWPEIEFLTMGGFFGYQNNYVRDNPSDGYNYASLAVSLCTPRSRGNVSIASADAAVPPLINPNWLTDPVDVELAVAAFKRARDFFGTSALKPVLIGDEYFPGERVATDAQIEDHVRKSFDTIFHASCTCAMGKREDQMAVVDSKARVIGVDALRVVDASAFPMLPPGHPQSTIYALAEKIACDISGAC
What is the function of this protein?
Patulin synthase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (By similarity).  PatE catalyzes the last step of the pathway which is the conversion of E-ascladiol to patulin (By similarity).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units.  The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol).  These first reactions occur in the cytosol.  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI.  The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole.  PatN catalyzes then the transformation of isoepoxydon into phyllostine.  The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol.  The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM.  Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (PubMed:19383676) (Probable).
What are the official names of this protein?
Patulin synthase, Dehydrogenase patE, Patulin synthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Vacuole. Secreted. Secreted, cell wall.
Protein: RL17_AGRLI
Sequence: MGRYSREPEIAAKSCKARGSNLRVHFKNTCETANAIRKMPLKRAVAYLKNVIGHKECVPFRRFNGGVGRCAQAKQWGTTQGRWPKKSAEFLLQMLRNAESNADYSGLDVDRLVIEHIQVNRAACLRRRTYRAHGRINPYMSSPCHIEMWLTEAESTPEGAKKGKKKKGTKDAVEKSSKRVKTAATAAH
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SP5_HUMAN
Sequence: MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIGQPGAAAPPDFLQVPYDPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDDLPWWSIPQAGAGPGASGVPGSGLSGACAGAPHAPRFPASAAAAAAAAAALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLKVAEAGVKREDARDL
What is the function of this protein?
Binds to GC boxes promoters elements.  Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).
What are the official names of this protein?
Transcription factor Sp5.
What is the protein family that this protein belongs to?
Belongs to the Sp1 C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARNF_YERPP
Sequence: MKGYLWGGASVVLVTVAQLVLKWGMMNIPLLSLADINVQFLTMYFVQLASVMCGLMGYALSMLCWFFALRYLPLNRAYPLLSLSYALVYLGAVLLPWFNEPATLLKTLGAGFILLGIWLINIKPIKAS
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNF34_PONAB
Sequence: MKAGATSMWASCCGLLNEVMGTGAVRGQQSGFAGATGPFRFTPNPEFSTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLILRNIPTDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSFFSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENAEDQNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS
What is the function of this protein?
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins.  Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis.  May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway.  Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation.  Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN.  Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells.  Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF34, RING finger protein 34, RING-type E3 ubiquitin transferase RNF34.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Nucleus. Nucleus speckle. Cytoplasm, cytosol.
Protein: RL9_YERPG
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNVEFFEARRAELEAKLADVLAAAEARATKINELVSVTISSKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTAGEHEVHFQVHSDVFAKLNVVVVPEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.