PharMolix/UniProtQA huggingface dataset:
Protein: CT18_HUMAN
Sequence: MSPPSSMCSPVPLLAAASGQNRMTQGQHFLQKV
What are the official names of this protein?
Putative tumor antigen NA88-A, Cancer/testis antigen 18, CT18.
Protein: RL2_POLNS
Sequence: MPLMKTKPTSPGRRSMVKVVNPDLHKGKPFASLLEPQFQKAGRNNNGHITTRHKGGGHKHHYRVVDFKRNDKDGIPAKVERLEYDPNRSANIALILFADGECRYIPAAKGMTVGQAIMNGSEAPIKSGNNLPIRNIPVGSTIHCVEIMPGKGAQVARSAGGSAVLLAREGVYAQVRLRSGEVRRVLIDCRATIGEVGNEEHSLRQIGKAGANRWRGIRPTVRGVAMNPVDHPHGGGEGRTGEGRVPVSPWGTPTKGYRTRRNKRTTSMIVQRRQKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CYB_MYOSA
Sequence: MTNIRKSHPVMKIINNSFIDLPTPSNISSWWNFGSLLGICLALQIMTGLFLAMHYTSDTATAFNSVTHICRDVNYGWILRYLHANGASMFFICLYLHVGRGLYYGSYMYTETWNIGMILLFTMMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLNRFFAFHFLLPFVIAAMVMVHLLFLHETGSNNPTGIPSNADMIPFHPYYTIKDILGLLLMIMTLLTLVLFSPDMLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILIIMPLLHTSKQRSMAFRPLSQCLYWLLVADLLTLTWVGGQPVEHPFVIIGQLASILYFSIIIILMPLTSLMENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PP147_ARATH
Sequence: MKSVMSKIKLFRPVVTLRCSYSSTDQTLLLSEFTRLCYQRDLPRAMKAMDSLQSHGLWADSATYSELIKCCISNRAVHEGNLICRHLYFNGHRPMMFLVNVLINMYVKFNLLNDAHQLFDQMPQRNVISWTTMISAYSKCKIHQKALELLVLMLRDNVRPNVYTYSSVLRSCNGMSDVRMLHCGIIKEGLESDVFVRSALIDVFAKLGEPEDALSVFDEMVTGDAIVWNSIIGGFAQNSRSDVALELFKRMKRAGFIAEQATLTSVLRACTGLALLELGMQAHVHIVKYDQDLILNNALVDMYCKCGSLEDALRVFNQMKERDVITWSTMISGLAQNGYSQEALKLFERMKSSGTKPNYITIVGVLFACSHAGLLEDGWYYFRSMKKLYGIDPVREHYGCMIDLLGKAGKLDDAVKLLNEMECEPDAVTWRTLLGACRVQRNMVLAEYAAKKVIALDPEDAGTYTLLSNIYANSQKWDSVEEIRTRMRDRGIKKEPGCSWIEVNKQIHAFIIGDNSHPQIVEVSKKLNQLIHRLTGIGYVPETNFVLQDLEGEQMEDSLRHHSEKLALAFGLMTLPIEKVIRIRKNLRICGDCHVFCKLASKLEIRSIVIRDPIRYHHFQDGKCSCGDYW
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g03880, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PEBB_PROM2
Sequence: MLIKDTIFYRPDWRWHIFLKYLTNNLSKYNCLEKIIPSEYSYKDSTYGSKKSKKNVNLCTWGVTHKKRIQFARAVCINSPKYSVLNFLIIPNTIYNVPFFGVDFVSLPNIYLLVLDFQPSLKIQNQYNNQLLEKLIKLKNHCHSSLPLAEEMSVDVARFFSPGAIWSKLPKEERSDFLIANQLYTSFKEYLDLYLEILFESKEVNIDLQKELINGQNNYLNYRRDNDPARPMLSSLFGKEFTESLIKEVLFTT
What is the function of this protein?
Catalyzes the two-electron reduction of the C2 and C3(1) diene system of 15,16-dihydrobiliverdin.
What are the official names of this protein?
Phycoerythrobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: CYOE_SACD2
Sequence: MTEQASISNHDVAGWRDYLELTKPNVVALMLLTSLIGMLLAVPGMVPIDILILGNLGIALCAGSAAAVNHLVDRKVDLKMARTFNRPIAKGRIDPTKAILFAAILGLAGMAILMVWVNHLTAWLTLASLVGYAFIYTFWLKRATPQNIVIGGLAGAAPPLLGWVAVTGEVHGHALLLVLIIFAWTPPHFWALAVHRKEEYANAKIPMLPVTHGEAYTKIQILLYTFILIAVTLLPYATHMLNELYLLGAVVLGIGFLYYAVAMMRNKNKNAGMDAFKYSIVYLMALFVVMLLDHYLLPTNIVS
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AEPE_BPA18
Sequence: MTSYYYSRSLANVNKLADNTKAAARKLLDWSESNGIEVLIYETIRTKEQQAANVNSGASQTMRSYHLVGQALDFVMAKGKTVDWGAYRSDKGKKFVAKAKSLGFEWGGDWSGFVDNPHLQFNYKGYGTDTFGKGASTSNSSKPSADTNTNSLGLVDYMNLNKLDSSFANRKKLATSYGIKNYSGTATQNTTLLAKLKAGKPHTPASKNTYYTENPRKVKTLVQCDLYKSVDFTTKNQTGGTFPPGTVFTISGMGKTKGGTPRLKTKSGYYLTANTKFVKKI
What is the function of this protein?
Cell wall lytic enzyme.  Hydrolyzes the link between L-alanine and D-glutamate residues in certain bacterial cell-wall glycopeptides.
What are the official names of this protein?
L-alanyl-D-glutamate peptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M15C family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEUD_XANC8
Sequence: MTPFTQHTGLVAPLDRANVDTDQIIPKQFLKSIKRTGFGPNLFDEWRYLDIGEPGRDNSTRPLNQEFVLNFPRYQGASVLLARENFGCGSSREHAPWALDEYGFRAVIAPSFADIFYNNSFKNGLLPIVLAEAEMDALFEQCLGNEGYQLTVDLAAQRVRRPDGVEYAFEIDAFRKHCLLNGLDDIGLTLQDADAIGRFEQGHRAQQPWLFGALQ
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RSMF_SHEPA
Sequence: MAHFNQNFLDSIERDLPSHLSMEDFIAYSNKPLRLSIRVNTLKISHDNFIDLMTPKGWHFEPIPWCKDGFWVTLTQEIQLGNTIEHLQGLFYIQEASSMLPPTALFEPLEVAVAAENTEDDGSDDFSNKIVLDMASAPGSKTTQIAALMKNQGLLIANEYSASRVKVLHANVARMGVANCALTHFDARVFGEYMFETFDSILLDAPCSGEGTIRKDPDALKNWDNNDDKGIVETQKALIESAFLALKVGGSLVYSTCALSRQENQDVCHHLKSLYGDAVEFGSLATLFPQADKACTEEGFLHVWPQIYDSEGFFVAKIYKTSAVERQLPEPRKQKNFPFTLAKPKQVEELAQYFRDSFSISLPDNAQVMVRDLEFWLFPSPVIPLIGKMRYQRIGIKLADALKKGYKVRHEAVLALSSPTRFELSDEQAKEFLMGRDISLLEKGKPQGEVIVSYASNPLGVAKHLGNKLKNNLPRDLVKDKIALYSHN
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTL4_RAT
Sequence: MGKKQKENEAYGNSAKYDPSFRGPIKNRGCTDIICCVLFLVFILGYIVVGLVAWVYGDPRQVLYPRNSTGAYCGVGDNKDKPYVLYFNILSCAAAINVISIAENGLQCPTPQVCVSSCPQTPWVVEGFQLSNTVGDVYKEYRNFCVPAVSPDMVVMDSLQKGLCPSFLLPSTPALGRCFPLPNINFTLPEQLQINNTTVSKGISGLLDSINARDVSVKIFEDFAQSWYWILVALGVALVLSLLFILLLRLVAAPLVLLLIVGVLAVLAYGIYHCWQQYRELRDQGVSITQLGFTANLSAYQNVKETWLAALIILAVLEGVLLLMLIFLRQRIRIAIALLKEASRAVGQMMSTMFYPLVTFVLLVICIGYWAVTALYLATSGQPQYVYWVHNTSTPGCEKVLVNVSCDPMAPLNSSCPELKCTFTGYSSSGLAQRSLFNLQIYGILGLFWTVNWVLALGQCVLAGAFASFYWAFHKPRDIPTFPLSSAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGSQNPVARCIICCFKCCLWCLEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNVVRVVVLDKVTDLLLFFGKLLVVGGVGVLSFFFFSGRIKGLGKDFKNPDLNYYWLPIMTSIMGAYVIASGFFSVFGMCVDTLFLCFLEDLERNDGSQERPYYMPKALLKILGKKNEVPTGGKNRKK
What is the function of this protein?
Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity).  Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity).
What are the official names of this protein?
Choline transporter-like protein 4, Solute carrier family 44 member 4, Thiamine pyrophosphate transporter 1.
What is the protein family that this protein belongs to?
Belongs to the CTL (choline transporter-like) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Apical cell membrane.
Protein: DUS3_COCIM
Sequence: MTQSFPNETTLNDGAKRLENEGSGNFEESPAKRIKLDKPENPIHAQPENNGAQRKKGTAPIREEYLVRSGQEPSVKQTSDVRDDDEAEAARHQERAGEKGGKQRKKQKGQNTARKFGKSQDEKGLCQSVSHSPELSPRTCQFGDNCRFEHNLRKYLKEYKREDLKTFNGMCPVWDAYGLCFSGWKCRFVGSHMTERELEDGRKELVLVEDEERKNAAMPLVEGGAEGGVFNSISTEQKVDLMKKRRKTPKSDAYTTWLDETSKQLEIHNHGRRFADENNVEANGEARDEVEDRRAQFKEPPFLPSEKRRLYFGSETPVLAPLTTQGNLPFRRLCVELGAQFTYSEMAMSLPIVQGHKGEWALMKAHQSEVLPPTIKPNQGVVKDYDHSRDLKFGVQISANKPWQALKATEVMTALCPHLRVVDLNCGCPIDLVYRDGAGSALLEHPSKLEKILRGMNAVSNEVPVSAKIRMGTKDNSPTALKLIERLVLGGPEFTEIGQGPAGVAAITLHGRSRQQRYTREADWSYISECAALIRRLNERSDDLTDTIREADDRLQAPGRRVYFLGNGDCYSHEDYYRAIGESGVDTVMIARGALMKPWIFEEIQAGQYLDKSASERLSIVEKFAKYGLNAWGSDEHGVGTTRRFLLELLSFTHRYIPIGLLEHLPPRIQDRPPAYKGRNELETLLASDNYKDWIKISEMFLGPAHKDFKFEPKHKSNSYEIEG
What is the function of this protein?
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.  Specifically modifies U47 in cytoplasmic tRNAs (By similarity).  Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
What are the official names of this protein?
tRNA-dihydrouridine(47) synthase [NAD(P)(+)], mRNA-dihydrouridine synthase DUS3, tRNA-dihydrouridine synthase 3.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NDK_METKA
Sequence: MAEVQREFVMIKPDGVVRGLVGEVIRRLERKGLKIVALEMRQLDRETAEKLYEEHRDKPFFEDLIEYVTSGPVVVMIVEGRKAVKVVRNIIGATDPAEAAPGTVRGDFALDIGRNVVHASDSPESAEREIEIVFGKDLSTIDYERCDEEWLYES
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA12_VESAF
Sequence: MMNLKYLLFFCLVQALHYCYAYGDPSLSNELDRFNPCPYSDDTVKMIILTRENKKHDFYTLNTIKNHNEFKKSTIKHQVVFITHGFTSTATAENFLAMAEALLDKGNYLVILIDWRVAACTNEMAGVKLAYYSYAASNTRLVGNYIATVTKMLVQQYNVPMANIRLVGHSLGAHTSGFAGKKVQELRLGKYSEIIGLDPAGPSFKSQECSQRICETDANYVQIIHTSNHLGTLVTLGTVDFYMNNGYNQPGCGLPIIGETCSHTRAVKYFTECIRHECCLIGVPQSKNPQPVSKCTRNQCVCVGLNAKTYPKTGSFYVPVESKAPYCNNKGKII
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylcholine with phospholipase A1 activity (6. 3 U/ml) (PubMed:23159790).  May act as an allergen and induce hemolytic activity (By similarity).
What are the official names of this protein?
Phospholipase A1 2, PLA1, Allergen Ves a 1.02, Vespapase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: EPAB_ASPNC
Sequence: MFFQGEGSIDIPVQDIISWIFDQARYEIEKPVYIDASNTSRSISWRQARTLVRQLAAGLRAAGLKDGDCVCLHSFNDIYYSILVLGIIAAGGIYMGTNPGYTSHELDYHLRVAQAKFVISDPEMLDRMIPAAEGNGIPKDRIWAFTTRESQVIATTGLAHWTALLNHGEADWRRLDDPNHAKTTVVARLFSSGTTGLPKPVDFTHYNIIAQHTLVYDAHPVPFETSRILSLPFFHAAAAPSAHFSALRLGDPSYVLRRFEPDLFLTTVAKHNITECTAVPPIILAILSHCTTPKYSNSLQSLKIVRCGAAPLDKTTQARFQSLLAPDATFTQVWGMTESSCIATMIPYPESDDTGSVGRLLPGMEAKIINTDGDDITAPDTTGEVCLRGPTVVRGYFNLPSANESAFDKDGFYRTGDLGYCDGKTRKWYLLDRKKDIIKVRGFQVAPAEVEGVLRNHPRIRDVAVVGVYDAEAKTEYPRAYVVRQDQSLQEEEVKEFVALRLAKYKRLDGGVRFVDAIPRNASGKILKRLLEDKRDEKL
What is the function of this protein?
Phenylacetyl-CoA ligase; part of the gene cluster that mediates the biosynthesis of nigerpyrone and its derivatives carbonarone A and pestalamide A (PubMed:30384904).  The biosynthesis pathway begins with the polyketide assembly by epaA to form phenylacetyl triketide precursor from successive condensation of two malonyl-CoA, presumably with one phenylacetyl-CoA starter unit produced by the phenylacetyl-CoA ligase epaB (PubMed:30384904).  For the nigerpyrone biosynthesis, the reactive polyketide chain is released as an aldehyde through the R-domain.  A nonenzymatic cyclization and dehydration may create nigerpyrone (PubMed:30384904).  For the biosynthesis of carbonarone A and pestalamide A, an extra methyl group is added through the C-methyltransferase domain.  Several further steps involving the dehydrogenase orf1, the cytochrome P450 monooxygenase orf2 and the FAD-dependent monooxygenase orf3 are required to form a carbonarone A precursor which is converted to carbonarone A via cyclization (PubMed:30384904).  The O-acetyltransferase epaC could catalyze the transfer of 2-methylsuccinyl-CoA, a common intermediate in the ethylmalonyl-CoA pathway, to generate the final product pestalamide A (Probable).
What are the official names of this protein?
Phenylacetyl-CoA ligase epaB, Pestalamide A biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: RS28_CAEEL
Sequence: MDKLTLARVTKVIGRTGSQGQCTQVRVEFINDQNNRSIIRNVKGPVREGDILTLLESEREARRLR
What are the official names of this protein?
40S ribosomal protein S28.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS28 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: TPPB_ARATH
Sequence: MTNQNVIVSDRKPILGLKTITVSVSNSPLFSNSFPTYFNFPRRKLLKLLEAADKNNLVVAPKITSMIDSMRDSSPTRLRSSSYDSVSDNDDKTSWIVRFPSALNMFDEIVNAAKGKQIVMFLDYDGTLSPIVEDPDKAFITHEMREVVKDVASNFPTAIVTGRSIEKVRSFVQVNEIYYAGSHGMDIEGPTNENSNGQSNERVLFQPAREFLPMIEKVVNILEEKTKWIPGAMVENNKFCLSVHFRRVDEKRWPALAEVVKSVLIDYPKLKLTQGRKVLEIRPTIKWDKGQALNFLLKSLGYENSDDVVPVYIGDDRTDEDAFKVLRERGQGFGILVSKVPKDTNASYSLQDPSQVNKFLERLVEWKRKTVGEE
What is the function of this protein?
Removes the phosphate from trehalose 6-phosphate to produce free trehalose.  Trehalose accumulation in plant may improve abiotic stress tolerance.
What are the official names of this protein?
Trehalose-phosphate phosphatase B, AtTPPB, Trehalose 6-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the trehalose phosphatase family.
Protein: RL2_ECO55
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SC29_CENLI
Sequence: KKDGYLVNKYTGCKVNCYKLGENKFCNRE
What is the function of this protein?
Binds to sodium channels (Nav) and shift the voltage of activation toward more negative potentials (By similarity).  This toxin is active on crustaceans.
What are the official names of this protein?
Toxin II.9.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GUAA_METCA
Sequence: MTDIHAQKILILDFGSQYTQLIARRVRELGVYSEIHPYDCGDDFITEFAPQGIILSGGPESVTGTGTPRAPASVFTLGVPVLGICYGMQTMAAQLGGKVEAVEHREFGYAQVRAHGHSQLLNGIEDHTTPEGHGLLDVWMSHGDQVVGLPPGFKLIASTESAPIAGMADEERRFYALQFHPEVTHTRQGKRILERFVRKLCQCEARWTTGNIVEDAITRVRNRIGAERVVLGLSGGVDSSVVAALLQHAIGEQLTCVFVDTGLLRLNEGDQVMATFAEHMGVRVIRVNAEERFLQALQGIADPEDKRKIIGRLFVEIFDEEAAKIEDARWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPETMKLQLVEPLRELFKDEVRQIGLELGLPYEMVYRHPFPGPGLGVRILGEVRKEYADLLRRADAIFIEELYRHDLYDKVSQAFAVFLPVKSVGVMGDGRRYDYVVALRAVETIDFMTARWAHLPYDFLDLVSRRIINEIPGISRVTYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PUR7_STAEQ
Sequence: MSLLYEGKAKRVFTTNIDGQLRVEYKDEVTAGNGAKKDTMIGKGKLNNQITSIIFDYLTHNHIDNHFIKQLSQTEQLVQQVDIIPLEVVVRNIATGSITKRLGFKKGHTFEEPLVEFFYKKDELNDPLITDDHVKLLGIANDEEIKQLKQMAKDINQVLIQLMNEMSLRLVDFKVEFGKTNGGKILLADEISPDTCRIWDKNTDTNFDKDVYRNNTGSLIETYQTFLNKLEDLK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CHIT_CARPA
Sequence: GIEKIISRSMFDQMLKHRNNPACPAKGFYTYDAFLAAAKSFPSFGTTGSTDVRKRELAAFLGQTSHETTGGWPSAPDGPYAWGYCFLKERNPSSNYCAPSPRYPCAPGKSYYGRGPLQLSWNYNYGPCGEALRVNLLGNPDLVATDRVLSFKTALWFWMTPQAPKPSCHDVLTGRWQPSAADTAAGRLPGYGVLTNLLNGGLECGKGPNPQVADRLGFFRRYCGLLGVGTGNNLDCYNQRPFG
What is the function of this protein?
Defense against chitin-containing fungal pathogens.  Shows activity on chitin, tetra-N-acetylglucosamine and chitosan.
What are the official names of this protein?
Endochitinase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
What are the subcellular locations of this protein?
Vacuole. Note=Vacuolar and protoplast.
Protein: GAG_JSRV
Sequence: MGHTHSRQLFVHMLSVMLKHRGITVSKTKLINFLSFIEEVCPWFPREGTVNLETWKKVGEQIRTHYTLHGPEKVPVETLSFWTLIRDCLDFDNDELKRLGNLLKQEEDPLHTPDSVPSYDPPPPPPPSLKMHPSDNDDSLSSTDEAELDEEAAKYHQEDWGFLAQEKGALTSKDELVECFKNLTIALQNAGIQLPSNNNTFPSAPPFPPAYTPTVMAGLDPPPGFPPPSKHMSPLQKALRQAQRLGEVVSDFSLAFPVFENNNQRYYESLPFKQLKELKIACSQYGPTAPFTIAMIESLGTQALPPNDWKQTARACLSGGDYLLWKSEFFEQCARIADVNRQQGIQTSYEMLIGEGPYQATDTQLNFLPGAYAQISNAARQAWKKLPSSSTKTEDLSKVRQGPDEPYQDFVARLLDTIGKIMSDEKAGMVLAKQLAFENANSACQAALRPYRKKGDLSDFIRICADIGPSYMQGIAMAAALQGKSIKEVLFQQQARNKKGLQKSGNSGCFVCGQPGHRAAVCPQKHQTSVNTPNLCPRCKKGKHWARDCRSKTDVQGNPLPPVSGNWVRGQPLAPKQCYGATLQVPKEPLQTSVEPQEAARDWTSVPPPIQY
What is the function of this protein?
Capsid protein.
What are the official names of this protein?
Gag polyprotein, Core polyprotein.
What are the subcellular locations of this protein?
[Matrix protein p10]: Virion. SUBCELLULAR LOCATION: [Capsid protein p27]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p14]: Virion.
Protein: BST2_CRIGR
Sequence: MAPTFYHYHPLPMDQKEPGCGIRWRCLAAASVLILVALVIPLIIFAVKANSEACRDGLRAQEECSNTTRLLQRQLTRSQDNLAQAEAQASTCNRTVVTLQDSLEKKVSQIQEKQALIQEQEAQIKEQEAQIKEQEAQIKEQKAHIQEQQVRIQKLEGEVEEFEQKLKKLRTAEEASITSKQNSAGSMAVSSLLVLAVPLFLLF
What is the function of this protein?
IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells.  Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other.  The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface.  In either case, their spread as cell-free virions is restricted.  Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV).  Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration.  Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection.  Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells (By similarity).
What are the official names of this protein?
Bone marrow stromal antigen 2, BST-2, Luminal membrane-associated protein GREG.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. Forms a complex with MMP14 and localizes to the cytoplasm (By similarity).
Protein: NCKX5_HUMAN
Sequence: MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG
What is the function of this protein?
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) (PubMed:18166528).  Involved in pigmentation, possibly by participating in ion transport in melanosomes (PubMed:16357253, PubMed:18166528).  Predominant sodium-calcium exchanger in melanocytes (PubMed:16357253, PubMed:18166528).
What are the official names of this protein?
Sodium/potassium/calcium exchanger 5, Na(+)/K(+)/Ca(2+)-exchange protein 5, Solute carrier family 24 member 5.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome. Note=Enriched in late-stage melanosomes.
Protein: FADB_VIBPA
Sequence: MIYQADTLQVKEIQDGIAELSFCSPKSVNKLDLATLESLDKALDALTSHQGLKGLMLTSDKDAFIVGADITEFLGLFAKTDAELDQWLQFANSIFNKLEDLPVPTISVLKGHTLGGGCECVLATDMRIGDKTTSIGLPETKLGIMPGFGGCVRLPRVIGADSAMEIITQGKACRADEALKIGLLDAVVETDALYESALQTLTSAINEKIDWQARRKQKTSPLTLSKLESMMSFTMAKGLVAQVAGPHYPAPMTAVITIEEGARFARNEALDIERKYFVKLAKSEEAKALVGLFLNDQYIKGIAKKAAKSASKDTERAAVLGAGIMGGGIAYQSALKGVPVLMKDIAQPSLDLGMTEASKLLNKRLAQGRIDGFKMAGILASITPSLHYAGIENSDVIVEAVVENPKVKATVLSEVESHVGEDTVITSNTSTIPINLLAQSLKRPENFCGMHFFNPVHRMPLVEIIRGEKTSDETINRVVAYAAKMGKSPIVVNDCPGFFVNRVLFPYFGGFSMLLRDGADFTKVDKVMERKFGWPMGPAYLLDVVGIDTAHHAQAVMAEGFPERMGKQGRDAIDALFEANKYGQKNGNGFYSYTIDKKGKPKKTFTEDILPVLADVCADKQEFDEQTIIQRMMIPMINEVVLCLQEGIIATPQEADMALVYGLGFPPFRGGVFRYLDSVGIAEFVEMAKQHADLGAMYHVPQMLIDMAAKGESFYGAQQQGSI
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.