PharMolix/UniProtQA huggingface dataset:
Protein: RL18_WOLPP
Sequence: MKRLYNFLSSYEKRKLRNRAKLDKSAGRLRISIFKSNKHFYVQLINDAKGTTLASASTLDDKIRNVCKGRVNAETIKQVSSLLIERLPSTKLQQRFVFDRGAYKYTGLISQFAEALRSSGFKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: KAPR_COLOR
Sequence: MFKSPFGANANPFGGASDGATVGGNAMHQVIEEEENDTVTSPTSPNFGMNAQSMFSGPFGGDASDDVLPSALRSPPNPESYPAQYNFSRRTSVSAESLKPSADTYDNWTPPVHDKTNEQLSRLKTAIAGNFLFSHLDDEQSAQILGALIEKPIPAKDIKVISQGDAGDYFYVVEKGSFDVYVNEKGTLQPGPEGMGEKVGTIQAGGSFGELALMYNAPRAATVISAEPGCTLWALDRLTFRRILMESTFSRRRMYEDFLREVPLLQTLTPYERSKIADALETQKYTPGATIIKEGDPGHSFYLLESGEADAYLGDGKESVKHYSKGDFFGELALLNDAPRAASIVATTDVKVASLGKSAFQRLLGPVEGIMRRTKYDDIKTGVEEMDPLQV
What are the official names of this protein?
cAMP-dependent protein kinase regulatory subunit, PKA regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the cAMP-dependent kinase regulatory chain family.
Protein: SYA_MESH7
Sequence: MEKLSANKIRQLWIDFFREKNHFFIESKPLVPQNDDSLLWINSGVATLKDYFTGKKIPPSKRLVNSQKALRTNDIENVGLTSRHHTLFEMLGNFSIGDYFKTEAIDYAYEFLTKKLKLDPKNLFITYYDGDDITFEKWKSLGFSNEKLIKGSRKTNFWDLGQGPCGPCSEIYFDRGPKFDSRGSELIKNEIENDRFIEIWNIVFSEFNNDGQQNYTPLKSKNIDTGAGFERIVSILQDGPTNYDTDLFLPIIAEIEKSTVFQYKIENYFLKEPRQTQINKSFRIIADHIRAITLAINDGVQPSNLHRGYIIRRLIRRAYWNGKKLGISHPFLYKLVEIVGKTLDYRFDIQTISKIILNEEENFAKTLEIGYNLLESQLKINKNQIKPVTVFKLFETYGFPVELTKEILAEKNIDFDLSQLVEFQEKHSQISRAKKTTGMQKVINSLTQIKAKISDFIGYHTHHIETKISFLANKDEEVAETNGENLSYVIFEKTPFYATAGGQKHDQGWIIQNNSTIEILDVFKDKFLNNIHVFKGKIVKNQPVFLKLDTKNRLNLERNHSGTHLLFASLRQEFGSEIKQLGSDNNENRLTFDFPLNRKPSDQEIKSVENRINSYINQKIKRKYLVTNLEEAQKLNAIMTLEESEYMDPNSLRLVIFDKITTDLCGGTHIENTELLEKFTILSCQSKGSGIYRIRAVTSWNKYFEFLKGKIQEILSKISALKNKIKKIEPNFGLNLPNLVDLEQQFDYLKKIEDDLKIYYKKLLKSQLRIVKSELDANKIIEIGKFSFYLDFNLPLHNLKQIAATWREQNPRISFILGANLVNNEFLIIVSSAILASNQILEKILEIFTGSGGGNYKIAQGKIQKKPEKEVFIKLLWENITEF
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MROH1_BOVIN
Sequence: MSETYAKRLSAILLDAVTDKDPQMQEQVCGALCDFGESKPAEVLSACEEHLRLHEKLAHPYRTIILRAMEIVVSNHISELDKDTARAIILLASNEMTKVKELVSDWQQAASSVLVAVGRRFISSVMEELLSKFQPGLLPHPCTVHTLASLSVSNVFGVVPFLTSILSTMLPMLGAAKHDSMKVVFCCALQRFSESILEYLANLDQAPDPTVRKDAFASDIFGAYDILFHQWLQSGGAKLRLAVVEALGPMSHLLPSEKLEEQLPKLLPRVLAFYKKHTETVHVSKSLGQILEAAVSVGSRTLDIHLNSLLAALHAQICVPVESSSPLVMSNQKEVLRCFTVLACCSPDRLLAFLLPKLDTSNERTRVGTLQVLRHVINAAAAQMEVKKPVILSSMKLPLLDTNNKVKRAVVQVVSAMAHHGYLEQPGGKAMVEYIVQQCALPPEAEIQKLGADSEALAADSVRAISVSTLYLVSTTVDRMGEVLWPYLLEFLVPIRFTRALSPLCRSLVHLAQKRQEAGAHAPLIQYNGNVHLPSPYAITTRLLAVSSHPYVGDGRGAASLRLLNVLHQDIHPALGQRWVTAIPLLLEHLDEYSEETLSQKEWEEKLLVFLRDSLAVVSDNTWVCHLTLEMCKQLPNYNGTPLEKNFLYKCVGTTLGAASSKVVRKHLRELLETARYQEEREHEGLACCFGICAISHLDDTLAQLDDFVKSDVLRKSAGIFNLFKNRSESEANKVRSALILCYGHVAAGAPRELLLARVEADLFWNMSECFSTKVLGIKVETQDPALRLSLVQSVCMATQAICSSAHSSSFHLSRKAELVAQMVEFIRAEPPDSLKTPIWKKAMLACTYLVTLEPALEEQVQADLIHSCLHRVMAVLPEPEEGDSPQEVSAAPTVGGDPQESLYLDTVQVLKDLLTSLLLWNMTPLGLQVMLEHLSPWIKSPRGHERVRAVGLSACLLQFFLQHLQISALVPFHNLGLLIGLFSPRCADLWPATRREAVSCIHSLLYLQLTCVGFSRDYQDDVAEQLLSLKDGLVHPDPAILFHTCHSIAQLIAKRLPPDHLINLLLTLFESLGDPDKNCSRAASVMINCLLKERGNMLQEKVPEIVSVLRSKLQETQEEHILQAAQHSVFALATHHCASVVSNLLGSPLPFDSHTCTLWRALALEPGLAAQVLGLLLEKISKDVLFEESQAFLLSSTPDRVATLLPLAATCALHEVASAPASGPAVLELYPQLFVALLLRVSCTVGVQPPRQLQAKERRSASSGLASRSLEPCSSAVDALQAVLVRGGNEDVVQCMELDGGWQLLRTSAGHEEGVTRLASAMAKFAGPRLPLVMKLLFTTQSSMYEVQRVTSTAFLAELLSSNVVNDLMLLESLLYNLMARQKDTSARVRRLVLHGLANITLGSPDKVQTHSPQLLTAMIGGLDDGDDPHSLVALEAMVGLARLMDLVDAWDLHAVLLHIAVRIRPFFDSERMELRSVSIGLFGHLNKACRGDCKDVFLEQVVGGLVPLLLHLRDPHAPVVTACRFALRMCGPNLECEELAAVFQRHLQEGHDLHFGEFLNTTCKHLMRHFPDLLGRLLSTSLFYYKSSWEDVRAAAPMLTGFLVLHMEAEQRPQVDLEQLLTALQLLLKDPALKVRLKAVKTLGRLVKFA
What are the official names of this protein?
Maestro heat-like repeat-containing protein family member 1, HEAT repeat-containing protein 7A.
Protein: AV331_PHYSP
Sequence: MMQWSAILIRTCFSGSGGEALTCATSEQQTRPELCFFFSVRSSWPSTISDGACLALVSAEQGATAGRNTLSLRSMMATEDMATSTRSLRSQATNVDDDANVSIENRGMNPSVLTKLGEFASTLTAGNTANKLWLMADVDPKSAFKLLGLDMPGVRFIDNPKMLQWLKFTKAYLDMKKSGFGETSAHALLYEKIGGPDLSLLLLSLKDAPDANSLVQKLTNSQFGMWHDARIEPEQLAQTVFKIQDVRKLPKNDPKLQVIDDYAKYHRKHRKFLNSIMII
What is the function of this protein?
Effector that suppresses the host mitogen-activated protein kinase (MAPK)-based plant defense activated by the Phytophthora elicitor to promote colonization of the Phytophthora pathogen (PubMed:18390593, PubMed:23530601, Ref. 4).  Neither directly inhibits MAPK kinase activity nor interacts with MAPK proteins but acts downstream by suppressing transcriptional activation of resistance marker genes such as FRK1, WRKY22 and WRKY29 (Ref. 4).  Confers avirulence in the presence of resistance protein Rps1k in host (PubMed:23530601).
What are the official names of this protein?
RxLR effector protein Avh331, Avirulence homolog protein 1k, Avirulence homolog protein 331.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell.
Protein: SYT_AGRFC
Sequence: MSEAISLTFPDGSVRSYPAGTTGREVAESISKSLAKKAVAIALDGTVRDLSETITDGKIEIVTREDGRALELIRHDAAHVMAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPEDLPKIEKRMKEIIQRNKPFTREIWSREKAKEVFAAKGENYKVELVDAIPEGQDLKIYYQGDWFDLCRGPHMASTGQIGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWATQEELDNYLHVLAEAEKRDHRRLGREMDLFHFQEEGPGVVFWHGKGWRMFQTLTAYMRRRLANTYQEVNAPQVLDKSLWETSGHWGWYQENMFAVKSAHAFTHPDDKEADQRVFALKPMNCPGHVQIFKHGLKSYREMPVRLAEFGNVHRYEASGALHGLMRVRGFTQDDAHVFCTEEQMAAECLRINDLILSVYEDFGFSEIVVKLSTRPEKRVGSDDLWDRAESVMLEVLKTIEEQSGGRIKTGILPGEGAFYGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDQNSEKTQPVMIHRAICGSMERFLGILIENFAGHMPLWFAPLQVVVATITSDADDYGREVAEALREAGMAVETDFRNEKINYKVREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQNQTSMSLEEAITSLVDEATPPDVKRKLAAKKQLA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP110_LACTC
Sequence: MSDSPGTPNGKDTIRNYEFTPIGYVKERETSVPAVANSDSRKRSSPYRSPAADDDGPPQKAFRADDTLNSTRIFNDSSFDDTLPSQSVMNSVRINGVSDLHDNGIEEENGGASNPLKEQQETLYKLNVENYNLRVKCNSLLKFLNNVTDEGELRKNLAVIDELQEWKGKYQELKKAYRSLQLKFDQSEHKDQADLEQDARSNEKEMRSLQKKLQEYQEQVTQSKKLVESLENKLGNSASGSKEIKEQFEHKSSLLQERIDKLESELAAKDKELEINRNEIKNLQNDLQKANHDSSSLADQKLQTRSKEIENLNNRLKSAVREREAAEHLLKESQNALRSLRAELSTLRQESDRKLDDLSVAKEKSERVLKERLEERTSQSERLQQRANSLEQNAAELSSRLQLRDQRIKALEDEARELQKMNQRIQDLNDGKDSEKLQAQNQKLDGLRSEIERIKNEKEELERDNDKLKKRIVAQATKSPALKANSRKSLEKDAEAEKLRSRVRELEQELRVSKDALNKLRHNYRRDTDELKLQLEGAETDQVSAKRSLEKEIDRLKFEIDSLRESRKDEIAIMENRFNLLRRENEQLSGQGGSQLASLQKSLTEKQKEINELVQRCSDNTMDRLKLNRELAKAQEAESEGKREASKLSARLEFITKEFVKYKEAKTQGGEAGADRLNEKWSEKYQHMKQRLLNELKVLQEENLELERATLERKGSAGSGTYNVGMSSLQDQLDYYRLKYHREVAHTNDLNVMNDYLNRVLRASAQHVRLDILKLENEAPPDAFPEFTYRGRLRFKTVALFVLAAVRVQRVSLKLRWDSQRLNYLQKKIALEQDKITW
What is the function of this protein?
Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.  Potential role in cross-linking filaments or anchoring other molecules.  It is essential for growth (By similarity).
What are the official names of this protein?
Spindle pole body component 110, Spindle pole body spacer protein SPC110.
What is the protein family that this protein belongs to?
Belongs to the SPC110 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Tightly associated with the nucleus. It is present in a granular pattern that excludes the nucleolus.
Protein: TRPB_RHOBA
Sequence: MSTAPSQQHASAQVPDPRGRFGDFGGRFVPETLTRALDELSEEYEKAKRDPEFQRELDGLLKTFVGRPSPLYHAKRLSSAVGGAQIWLKREDLNHTGAHKINNTIGQALLTLRMGKTRVIAETGAGQHGVASATACAHFGLPCTVYMGAEDIRRQKPNVFSMKLLGANISAVESGSRTLRDAVNEAMRDWMSSVEDTHYIIGSVIGPHPFPMMVRDFQSVIGRETREQCRDTFGRLPDCVVACVGGGSNAAGMFYPFVEDEGVRMVGVEAGGRSATPGDHASPLSYGNPGVLHGSYSYVMQDEDGQTCDVHSMSAGLDYPGVGPEHSYWKDTKRVDYIDCRDDEALTAFERLASSEGILAALETSHAVAKAIEIAGKMSDQEHLVICLSGRGDKDSMEIARLRGEEW
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: AYR1_YEAST
Sequence: MSELQSQPKKIAVVTGASGGIGYEVTKELARNGYLVYACARRLEPMAQLAIQFGNDSIKPYKLDISKPEEIVTFSGFLRANLPDGKLDLLYNNAGQSCTFPALDATDAAVEQCFKVNVFGHINMCRELSEFLIKAKGTIVFTGSLAGVVSFPFGSIYSASKAAIHQYARGLHLEMKPFNVRVINAITGGVATDIADKRPLPETSIYNFPEGREAFNSRKTMAKDNKPMPADAYAKQLVKDILSTSDPVDVYRGTFANIMRFVMIFVPYWLLEKGLSKKFKLDKVNNALKSKQKNKDD
What is the function of this protein?
Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively.  Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA) (PubMed:1512203, PubMed:10617610).  Also has triacylglycerol (TAG) lipase activity.  Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs (PubMed:24187129).  Required for spore germination (PubMed:10617610).  Plays a role in cell wall biogenesis, but this effect may be indirect by affecting the activities of cell wall synthesis enzymes (PubMed:23956635).  Lipolysis of TAG by AYR1 is essential for starvation-induced autophagy (PubMed:26162625).  Forms an NADPH-regulated cation-selective channel in the mitochondrial outer membrane (PubMed:28916712).
What are the official names of this protein?
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase, ADR, 1-acyl DHAP reductase, Acyl/alkyl DHAP reductase, Acylglycerone-phosphate reductase, Triacylglycerol lipase AYR1, TAG lipase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Lipid droplet. Mitochondrion outer membrane. Endoplasmic reticulum.
Protein: NAGB_SALHS
Sequence: MRLIPLSTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGEVSFKHVVTFNMDEYVGLPKEHPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDGDVNQVPKYALTVGVGTLLDAEEVMILVLGHQKAQALQAAVEGNVNHMWTISCLQLHPKAVVVCDEPSTMELKVKTLKYFNELEAENIKGL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: FETP_LEGPL
Sequence: MSRTVFCCKLKQEAEGLEKQPFPGELGKKVFNEVSKQAWNMWLSHQTMLINEYRLNLIEARAREFLKEEMQKYFFGEGSDKPSGYKEIK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: CYC6_CLAGO
Sequence: VDAELLADGKKVFAGNCAACHLGGNNSVLADKTLKKDAIEKYLEGGLTLEAIKYQVNNGKGAMPAWADRLDEDDIEAVSNYVYDQAVNSKW
What is the function of this protein?
Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.
What are the official names of this protein?
Cytochrome c6, Cytochrome c-553, Cytochrome c553, Soluble cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PetJ subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: GLI4_XENLA
Sequence: MEHYLRSVHNSPTLSMISAARGLSPAEVAHEHLKERGIYGLAPPPPPGTTPTEYCHQMAFLASHASPYGELLVQSAAAGNTSHLHDYLTPMDVSRFSSPRVTPRLSRKRALSISPLSDASIDLQTMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGAISPAFSFPIHKPCSLSAALSQQRSLSSSFGHTPLLHPSPTFASRQQGALTSANPAPPSNNSSAPDSVLNKVSSESAVSSTVNQVIHKRSKVKTEEEADSVRFPQPPDHLTDLKEDLDKDECKQEPEHIYETNCHWDGCSKEFDTQDQLVHHINNDHIHGEKKEFVCRWQDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYVCDHEGCNKAFSNASDRAKHQNRTHSNEKPYICKVPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKHRNDIIQKPSLPKENGDNEASAKLSGREHSDSVSRDQEHCLQTRTIKTEDNMMHQSSPGGQSSCSSEPSPYGNTNNIDSGVDVSLAWQGSLGDLFGLEETSPVVDSTVSSWQRSGRPATPETQRIHSAETGTAEEREIKDNERFLLIYEPNATCQNTRLPTISANGFDVIGVPSSVLINPRAIELSMNDVTMMNQLNERRDSTSSTLSSAYTSRRSSGISPYFSSRRSSETSQFGGRLNNSSSADSYDPISTDASRRSSEASQHSGLPNLLNLTPAQHYRLKAKYAAATGGPPPTPLPNMDRIGLRNKLSLMDGADFPLPPFRQLPVPRRCSDGGGNAGLTPMYPHEIPGNNSRRASDPVRRTAGIDDKPLPRFSRFHSMNSMNTLHPPSLSERRNGGLQHYTCSDGGLHRHVYSPRPPSISENVAMEAISCDADVPGGDDDLMLPDDVVQYIRSQNREAPEQNLQTEYSSPARNLQSNTKSFHNNTPEQPRAPGAYLSRNFPALAECLGQTANMQDNNMPVQWNEVSSGTVDVSDLPKQQFAAGNLAVVQQKQNFAQYQSFNQAPMQRAHNIMGQGQESVQRNISVNGQRFNYLQQRQQQMSQCQIVSSDFIPQQRYSQSQSMLSSRAMQEGQSQISPSCNNMVERPGVHTHAAPSNTLNHQRLAVHGAPTQGFANNFSVNQDGLHPPNAYTVQPQKNGLEPQQNTLGMSGQAFNHGMIQPRPPAAPHPPNRPRNIHPVHHPPYMRSPHPVSELSPGQQTAEATPKRTSENTDPTPKDNNLLYYSGQIHMYEPNGNFGSGIDCTVRQLPTMPSPGANQVTSTVDSQGLEHPPVIDFDAMMDDGDHSSLMSGTLSPGLLQSFSQTSSRLTTPRNSLTLPSIPAGINNMAIGDMSSMLTTLAEESKFLNLMS
What is the function of this protein?
Has an essential role in the early embryonic patterning of mesoderm and neuroectoderm.
What are the official names of this protein?
Zinc finger protein GLI4, Neural-specific DNA-binding protein xGLI4, xGLI-4.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLYA_WOLSU
Sequence: MNYALETNDKEIFDLIHEELDRQNTHLEMIASENFTFPAVMEAMGSVLTNKYAEGYPYKRYYGGCEFVDRVEEIAIERAKKLFGCGFANVQPHAGSQANVAVYNALLKPYDKILGMDLSHGGHLTHGAKVSVTGQTYQSFFYGVELDGYINYDKVEEIAKIVKPQMIVCGFSAYARELDFKRFREIADSVGALLLGDVAHVAGLIVAGEYPNPFPHCHIVTTTTHKTLRGPRGGMILTNDEEIAKKIDKAVFPGMQGGPLMHVIAAKAVGFGENLKPEWKEYAKQVKANAKVLAKVLMARGYTLVSGGTDNHLILVSLLDKEFSGKDADRALGEAGITVNKNTVPGETRSPFVTSGVRIGSAALTARGMREKEFEFIATKIADVLDDVNNAAKHAEIKKEIAEFAKGFPVYTKAIF
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL544_MIMIV
Sequence: MRMLIFTYKLERYIKNKILPKILVVPDRDKYQIKGSFRRRIPYITDIDIVNNVHPEYDDTNIYQRIVDLINSFTNDNQIKLIYVICGTDDRFLLTEYSDEEIEKIKILLNPTELVELNNVLSKYQDDLNKKVFYINEIIWDLYKLRWTSSEVLAGKKILRGGIEVSFQDVVKNNSILLLQYFVKIEYYPIGFDIAVRYKPINLITAYQNAAFYQLKLANYSKEYYFMLFPLRFYFKNDPTISKQLEYIIETKFGLYKQLLVRIDSYRTIYESGNLDLDTAKSIIISIIKDIRKLNGIDMNIIDKIQEVSNNSAGQDKIIAWNTLLTQLYTNINKSVNKQSKKYFTRYINIIPKEDRKLCCLEEEHVLQSGGINFESTNFLTKKKLIY
What are the official names of this protein?
Uncharacterized protein L544.
What are the subcellular locations of this protein?
Virion.
Protein: MDTJ_YERPE
Sequence: MIYWIFLGLAIIAEIIGTLSMKYASVSGEMTGHIVMYFMITGSYVMLSLAVKKVALGVAYALWEGIGILIITIFSVMWFGETLSPLKIAGLVTLIGGILLVKSGTRKPKQPNCHRGNRPPSVQELKTQTTGHHKGVAVESGEHHAAA
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtJ.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PQQE_ACIBS
Sequence: MTEGVGLPLWLLAELTYRCLLQCPYCSNPLDYAQHKNELTTQEWFDVFDQARQMGAVQLGFSGGEPLVRQDLEQLVAHAHQLGFYTNLVTSGMGLTEQRISHLKQAGLDHIQISFQASDPVLNDALAGSKHAFEQKYEMCRLVKKYDYPMVLNFVIHRHNIDQIDKIIELCLELNADTVELAICQFYGWAFLNRQGLLPTQEQLIRAERITNEYREKLKAQNHPCKLIFVVPDYYEERPKACMNGWGKIFFTVAPDGMALPCHAARQLPISFPNVREQSLSRIWYESTGFNRFRGDAWMPEGCRSCPDKDRDFGGCRCQAYMLTGDASNADPVCGKSPYHQFIEQARAESEIDSSLEKLVFRNSRNSKQFTVQQNIPVQNIVDD
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.
Protein: I2BP1_MOUSE
Sequence: MASVQASRRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRSHVLPEGRSPGPPALKHPTSKDLASTGSQGSQLPPPQAQAQPSGTGGSVSGPDRYDRATSSSRLALPSPALEYTLGSRLANGLGREEAVAEGARRALLGSIPSLMPPGLLAAAVSGLGGRALTLAPGLSPARPLFGSDFEKEKQQRNADCLAELNEAMRGRAEEWHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATARPPGYEFELKLFTEYPCGSGNVYAGVLAVARQMFHDALREPGKALASSGFKYLEYERRHGSGEWRQLGELLTDGVRSFREPAPAEALPQQYPEPAPAALCGPPPRAPSRNLAPTPRRRKASPEPEGETAGKMTTEEQQQRHWVAPGGPYSSETPGVPSPIAALKNVAEALGHSPKDPGGGGGSVRAGGASPAASSTTQPPAQHRLVARNGEAEVSPTAGAEAVSGGGSGTGATPGAPLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPWAFMQGEIATILAGDIKVKKERDP
What is the function of this protein?
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities.  May act as an E3 ligase towards JDP2, enhancing its polyubiquitination.  Represses ATF2-dependent transcriptional activation.
What are the official names of this protein?
Interferon regulatory factor 2-binding protein 1, IRF-2-binding protein 1, IRF-2BP1, Probable E3 ubiquitin-protein ligase IRF2BP1, Probable RING-type E3 ubiquitin transferase IRF2BP1.
What is the protein family that this protein belongs to?
Belongs to the IRF2BP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BRME1_HUMAN
Sequence: MTKRKKLRTSGEGLCPPKPLKNPRLGDFYGDPQSSMLGCLHHPEEPEGKLGPVPSTQQHGEEPGKAVSSSPDEETGSPCRLLRQPEKEPAPLPPSQNSFGRFVPQFAKSRKTVTRKEEMKDEDRGSGAFSLETIAESSAQSPGCQLLVETLGVPLQEATELGDPTQADSARPEQSSQSPVQAVPGSGDSQPDDPPDRGTGLSASQRASQDHLSEQGADDSKPETDRVPGDGGQKEHLPSIDSEGEKPDRGAPQEGGAQRTAGAGLPGGPQEEGDGVPCTPASAPTSGPAPGLGPASWCLEPGSVAQGSPDPQQTPSRMGREGEGTHSSLGCSSLGMVVIADLSTDPTELEERALEVAGPDGQASAISPASPRRKAADGGHRRALPGCTSLTGETTGESGEAGQDGKPPGDVLVGPTASLALAPGSGESMMGAGDSGHASPDTGPCVNQKQEPGPAQEEAELGGQNLERDLEGFRVSPQASVVLEHREIADDPLQEPGAQQGIPDTTSELAGQRDHLPHSADQGTWADSLAVELDFLLDSQIQDALDASDFEAPPEQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAFKRLNYRKTKLGGKAPLPYPSKGPGNIPRGDPPWREL
What is the function of this protein?
Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair.  Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination.  Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility.
What are the official names of this protein?
Break repair meiotic recombinase recruitment factor 1, Pre-T/NK cell-associated protein 3B3.
What are the subcellular locations of this protein?
Chromosome. Note=During meiosis, recruited to chromosomes and localizes on recombination sites in a double-strand break-dependent manner. First appears on the chromosome axis at leptotene. Along with the progression of meiotic recombination, released from the axis to form bridge-like structures linking homolog axes before they are synapsed. Finally, located between synapsed homolog axes and on the synaptonemal complex (SC).
Protein: YP13B_YEAST
Sequence: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRPITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMNTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
What is the function of this protein?
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane.  Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
What are the official names of this protein?
Transposon Ty1-PR2 Gag-Pol polyprotein, Gag-Pol-p199, TY1A-TY1B, Transposon Ty1 TYA-TYB polyprotein, p190.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MCHR2_MACMU
Sequence: MNPFHSSCWNTSAELSNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIIGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTSWRTRYKTIRINLGLWAASFVLALPVWIYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVAVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRVTDKEIKNMGNTLKSHF
What is the function of this protein?
Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
What are the official names of this protein?
Melanin-concentrating hormone receptor 2, MCH receptor 2, MCH-R2, MCHR-2, G-protein coupled receptor 145, MCH-2R, MCH2, MCH2R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.