PharMolix/UniProtQA huggingface dataset:
Protein: RNAS6_SAGOE
Sequence: MVLCFPLLLLLLVLWGQVCPLHAIPKHLTRAQWFEIQHIRPSPLQCNRAMSHINNYTQHCKPQNTFLHDSFQNVAAVCDLLSITCKNGLHNCHQSLKPVNMTDCRLTSGKYPQCRYSAAAQYKLFIVACDPPQKGDPPYKLVPVHLDSIL
What is the function of this protein?
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine.  Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P. aeruginosa, A. baumanii, M. luteus, S. aureus, E. faecalis, E. faecium, S. saprophyticus and E. coli.  Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria.  Probably contributes to urinary tract sterility.  Bactericidal activity is independent of RNase activity.
What are the official names of this protein?
Ribonuclease K6, RNase K6.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Lysosome. Cytoplasmic granule.
Protein: PCKA_STAA3
Sequence: MSVDTYTETTKIDKLLKKPTSHFQLSTTQLYNKILDNNEGVLTELGAVNASTGKYTGRSPKDKFFVSEPSYRDNIDWGEINQPIDEETFLKLYHKVLDYLDKKDELYVFKGYAGSDKDTMLKLTVINELAWHNLFAKNMFIRPESKEEATKIKPNFTIVSAPHFKADPEVDGTKSETFVIISFKHKVILIGGTEYAGEMKKGIFSVMNYLLPMQDIMSMHCSANVGEKGDVALFFGLSGTGKTTLSADPHRKLIGDDEHGWNKNGVFNIEGGCYAKAINLSKEKEPQIFDAIKYGAILENTVVAEDGSVDFEDNRYTENTRAAYPINHIDNIVVPSKAAHPNTIIFLTADAFGVIPPISKLNKDQAMYHFLSGFTSKLAGTERGVTEPEPSFSTCFGAPFFPLHPTVYADLLGELIDLHDVDVYLVNTGWTGGKYGVGRRISLHYTRQMVNQAISGKLKNAEYTKDSTFGLSIPVEIEDVPKTILNPINAWSDKEKYKAQAEDLIQRFEKNFEKFGEKVEHIAEKGSFNK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRK5_BOVIN
Sequence: MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHINQCEDLRRTIDRDYCSLCDKQPVGRLLFRQFCETRPGLESYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFITQVGRDLVSQTEEKLLQKPCKELFSACVQSVHDYLRGEPFHEYLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSRFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENIVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQSEMIETECFKELNVFGPHGTLSPDLNRSHPPEPPKKGLLQRLFKRQHQNNSKSSPNSKTSFNHHINSNHVSSNSTGSS
What is the function of this protein?
Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs).  Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation.  Phosphorylates a variety of GPCRs, including adrenergic receptors (Beta-2 adrenergic receptor), muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors.  In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1.  Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors.  Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription.  Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis.  Phosphorylation of ST13 regulates internalization of the chemokine receptor.  Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity).
What are the official names of this protein?
G protein-coupled receptor kinase 5, G protein-coupled receptor kinase GRK5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane, targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion (By similarity).
Protein: RF1_SHESA
Sequence: MKESVIRKLEGLLERNEEVLALLGDASVIADQERFRALSKEYSQLEEVVAGFKAYQQAQADLESAKEMLEEDDAEMREMAQEEIKAAKAELERLEAELQILLLPKDPNDDTNAFIEIRAGAGGDEAAIFAGDLFRMYSRYAEANRWQLEIMSSNEGEHGGFKEIIVKVSGEGAYGKLKFESGGHRVQRVPETESQGRVHTSAVTVVVMHEVPEAEAISINPADLKVDTFRSSGAGGQHVNKTDSAIRITHIPTGIVVECQDQRSQHKNRAQAMSVLAARIQAVEDEKRRSAEESTRRSLVASGDRSERVRTYNFPQGRVSEHRINLTLYRLNEVMEGDLDAILGPLMQEHQADLLAALADEQG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOG1_HUMAN
Sequence: MSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEEPGSPWSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAEANTEIHRKDDALWCRVTKPVPAGGLLSVLLTAEPHSTPGHPVKKEPAEPTCPAPAHDLQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQGTGSPAAAATDEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHSCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPATKLPPDSLGSFQQQHTALQGPLASADLGLAPTPSPGLDRKALAEATNGEARAEPLAQNGGSSEPPAAPRSIKVEAVEEPEAAPILGPGEPGPQAPSRTPSPRSPAPARVKAELSSPTPGSSPVPGELGLAGALFLPQYVFGPDAAPPASEILAKMSELVHSRLQQGAGAGAGGAQTGLFPGAPKGATCFECEITFSNVNNYYVHKRLYCSGRRAPEDAPAARRPKAPPGPARAPPGQPAEPDAPRSSPGPGAREEGAGGAATPEDGAGGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAAPPGPPGPAAPPAPSPAAPVRTRRRRKLYELHAAGAPPPPPPGHAPAPESPRPGSGSGSGPGLAPARSPGPAADGPIDLSKKPRRPLPGAPAPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPPPGALGLPAAACPYCPPNGPVRGDLLEHFRLAHGLLLGAPLAGPGVEARTPADRGPSPAPAPAASPQPGSRGPRDGLGPEPQEPPPGPPPSPAAAPEAVPPPPAPPSYSDKGVQTPSKGTPAPLPNGNHRYCRLCNIKFSSLSTFIAHKKYYCSSHAAEHVK
What is the function of this protein?
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.  Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3.  Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context.  The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1.  May be involved in regulation of some genes in gonads.  May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).
What are the official names of this protein?
Zinc finger protein ZFPM1, Friend of GATA protein 1, FOG-1, Friend of GATA 1, Zinc finger protein 89A, Zinc finger protein multitype 1.
What is the protein family that this protein belongs to?
Belongs to the FOG (Friend of GATA) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1136_SULTO
Sequence: MNFLEIKGLRVFYPESSYSLNVDSLEVKEGETILIAGKSGSGKSTLLNSINGVIPHEIEVEEEGEVKVFGINVRNSTIQQIARFVGTLLQDPDSQIFNYYVIEELAFGAENLNIPREEILYRINKVSQIVGISHLLNKETFRLSGGEKQRVVLGSILIMNPKALILDEPTSSIDLKGTKEILTTLRGLKEKMSMIIAEHKINKVLEFVDRIIILDKGKIIYDIKRDHVKEVDFEDLGLEPLRPSPLPKKRRDGEVILEAKVKVTDGNRTIVDTEIVLRKGISALIGDNGSGKSTLLKALAGILPINLKFYGSIKVEGKEISKLPVEKRGEIIAYLPQEIDLMFTKKTVKEEVSYPAKVRKKYDERVIKELLKRFNLPEDRDPFLLSVGQKRRVAISSLLATGVKVFLLDEPTTGQDWYNRKMLGEELRSIDATFLVVTHDPLFVYYYADRVYKMVNGRVIPISPEDVIKDW
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein STK_11360.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SPO11_ENCCU
Sequence: MALAPTSSAISGSLRSSMLKLLMRLKSRTLATRLRLYEIIIEMQELGITRNEREIFYMDVNVFRTQSVVRRLVSSIASELQISKHDLGVRNTLKGIFIGRLGFVRHHGLGMVEMSSKGGCPQLIPDMSDIAEVLCDYKKTVVVEKDTVLQRIASEIEREKCLEEILFVCGKGYPCKNTVLLLKMIEHKTAVAGLFDLDPFGIHIFCIYKYGSKETPDIRVETIMRIGVCMEDVLEKNAYKDVFVKLNVHDLKMINRLVRFGELSADLLFLRKIDGKVEMEALFSKEPRRLRYFLFRMLERISS
What is the function of this protein?
Required for meiotic recombination.  Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity).
What are the official names of this protein?
Probable meiosis-specific protein SPO11 homolog.
What is the protein family that this protein belongs to?
Belongs to the TOP6A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COAD_ECO8A
Sequence: MQKRAIYPGTFDPITNGHIDIVTRATQMFDHVILAIAASPSKKPMFTLEERVALAQQATAHLGNVEVVGFSDLMANFARNQHATVLIRGLRAVADFEYEMQLAHMNRHLMPELESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPENVHQALMAKLA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CS4F1_RHORT
Sequence: MAPSDTPPSAEDLPSQGELALFAPPATAEDALVPASMVNAWIYCPRLAVLEWGRGEKARSVDLIAGLRAHQATESGPTPALPDPMVLREDQSLKTRRLSLSSERLGLTAELDLLDVEEGMVIPVEIKVGKRPSVDEGAYLPERAQVCAQALLLREAGYTCLEGALWFAESRERVTVDLTEALVTATLVATSDLRLTVASGRLPPPLDHSAKCPRCSLLPICLPDEIAWFRKGSIARTPPPPASPALPLYGQTPGARIGKKDYTLVIQVEGEADRSLALDEISEVVLAGPVSLTTPAIHELLRREIPVAWMSSGFWFLGSTGGQGPRSAAVRTAQYALAGDERRRQAFARDLVSAKIRNGRTLLRRNWRGAEAERQIALDRLARLAERATTAETTACLLGIEGEAAAVYFRAFPQLFTQAVTTLPAFAFERRNRRPPADPVNACLSLCYAVLTRTLSSALSIAGLDPWKGFYHTERPGRPALALDLIESFRPVLADSTVLMVLNNGEIGTNDFLYAGGGCALKPNARRGLIAAYERRLDQETTHPVFGYQLSMRRLIQVQARLLARFVSGDIPRYPHYCPR
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).  The Cas4 region acts as a ssDNA exonuclease, while the Cas1 region acts as a dsDNA endonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).
What are the official names of this protein?
CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the CRISPR-associated endonuclease Cas1 family.
Protein: RIMO_BRUA4
Sequence: MSAPRVSFVSLGCPKALVDSERIITSLRSEGYEISRKHDGADLVIVNTCGFLDSARDESLDAIGLALNENGKVIVTGCLGAEPDVIRERHPNVLAITGPQAYESVMSAVHEAVPPAHDPFVDLVPPQGVKLTPRHYAYLKISEGCSNRCSFCIIPALRGDLVSRPIDSVLREAEKLVNAGVKEILVISQDTSAYGLDIKYQEAMWQDRTVRTKFLDLSRELGDMGVWVRMHYVYPYPHVDEVIPLMAEGKILPYLDIPFQHASPAVLKNMRRPAHQEKTSRRIQAWRETCPDLAVRSTFIVGYPGETEEDFEILLDWLDEAKIERAGCFKYEPVKGAKANDLGLEQVPEEIKEARWHRFMAKQQQISTNLLKKKVGKRLPVIIDEANGTIGKGRTRYDAPEIDGSVHIQSRRPLRVGDIVTVKIEASDAYDLHGIAV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP3E_BACSU
Sequence: MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQTFIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQLFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTGSQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSKKTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIEKRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADKKNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALALAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISGEAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVYNGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEGAKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVITGVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLSDDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSMLQRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS
What is the function of this protein?
Plays an essential role during sporulation.  Required for the translocation of the chromosomal DNA from mother cell into the forespore during polar septation, for the final steps of compartmentalization in the presence of trapped DNA, and for the final steps of engulfment.  The N-terminus mediates localization to the division septum and is required for both septal membrane fusion and engulfment membrane fusion.  May form DNA-conducting channels across the two lipid bilayers of the septum after cell division.  The C-terminus functions as a DNA motor that exports DNA in an ATP-dependent manner from mother cell into the forespore.  DNA-binding proteins are stripped off the chromosome during translocation, which may play a key role in reprogramming developmental gene expression in the forespore.  The two arms of the chromosome are simultaneously pumped into the forespore, which suggests that the septum contains at least two channels, one for each arm.  Required for separation of chromosome termini.  Also required for optimal chromosome partitioning in vegetative cells, by actively moving chromosomal DNA trapped within the division septum into the daughter cells.
What are the official names of this protein?
DNA translocase SpoIIIE, Stage III sporulation protein E.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the middle of the sporulation septum, then moves to the forespore pole before the completion of engulfment. Delocalizes after membrane fusion is complete. During sporulation, is exclusively assembled on the mother-cell side of the septum. During vegetative growth, assembles at the division septum when DNA is entrapped in the membranes.
Protein: C7BL1_HELAN
Sequence: MELFTIFSIVVSSLILFTFWSLKVPKNLPPGPPKLPIIGNIHLLDKIAPHRNLRNLARKYGPIMHLRLGQVSTVVISSPRLAHEIMKTQDLSFADRPTTTTSQIFFYKASNIAWARYGNYWRQMKKICTLELLSAKKSRSFFYIREEELTRTYKFLDFSSGTPITLRDTIQEMVNNVVSRATLGDVSEDRQFIIDSTYTMLKSFNSFNLFNYYPSLSFINVISGKQAQWLKMHKEVDVILEKILREHRSRPRGKNDHEDLVDVLIRIKETGDLDMAITDDNIKAIILEMLTAGTSSSSMTIEWAFTEMMRNPKIMKKAQTEVRSVVKGDRVTEADIQNLDYTKLVIKETLRLHGVPILVPRENQEDCVVNGYDIPAKTRLLVNAWACATDPDSWEDPDSFIPERFENNSIGYSGADFEFIPFGAGRRICPGMNFGMGTVEYVVANLLLHYDWKLPDGMKPHDIDMREITGISTLPIHPLKIVPISLSK
What is the function of this protein?
Involved in the biosynthesis of germacrene-derived sesquiterpene lactones (PubMed:30468448).  Hydroxylates germacrene A acid to 8-beta-hydroxy-germacrene A acid (PubMed:21515683, PubMed:29758164).  Unlike 6-alpha-hydroxy-germacrene A acid, this compound cannot undergo spontaneous lactonization (PubMed:21515683, PubMed:29758164).
What are the official names of this protein?
Germacrene A acid 8-beta-hydroxylase, HaG8H, Cytochrome P450 71BL1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: HDC_DROME
Sequence: MAPRRNSNISSSGNSTQQQHQQQLQQQHQTQQHQLLQFYAENVNSSGVLMAPMQGTGGVGGVGGGGMVHCCLPSGDCRKLDTLIHLNELSLADCIRVLCNNENCSAGQYMHRECFEWWEASVLQALKANGRARSWSERQRLQHLWTKKGYELVQKACSCKCGRGQLRKDLDWVPPSSQGVIYLNGSGNRPTLANGSLSEDDDKKKAKKKRNRNNNNNNGGGGGGGAGVNGNTKTPLSNNNGNSYAGLTPNPNVGVIGSGLPHNNGNTASNGSSGNNGSSGVLQTSALATFSNILNTNNVLGLDLRARAGSLSSSGAGSGSTSPSDSQSSGEISVSPVQQLLPQQQQQQQQSLLIQPLGPAFGSNLLQNGLGLSKNLLIAPQQQQQQQLQQQQQQQNNLPALANISNFKPLASYEQQQLVQQQKNKEVELYSDRVRSTSGCNGIFSRRLDFSSFNLLPKTRLNSYQVKIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCIEVKYEGRTLYLTCVCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQQRLSFYSDYSHGVTCPYCNTQDTHFVKPLTFCYAKTTATRLPTLAXHEAPLESPVGTGATTTQVPNAQGSPTASGCSSNTIASKQPPKQPLYNAAIDYSAPLQQQINPDLIGAHPHAQQHQQQVRQQQQQQQQQQPQQQQQQQQQQTQQQQSQQQQQQQQQQHQPVVSTFQRGNFPQQSHKTMNMMAMADVMSKYQQQQHQQQQQQRQQQHNLQPQQQHATQKGLEGLLLTNTNTSNNNSSSSSSSSISNLIISHNSASNTGNKMQPTWGQSDAISALWGCSSSSSGCSSGSGSQPSLSPTASSNGNDGSKMMLWAAQSSPQNAATLRDGFKELQRQQPPQQQVPQQQPHAASPTASLTSSSSSSNGWSASHYGKPNIWELPGSTGQRTPASSHDIFTDLLCNLSISQDNSSQQASSKADASDVSSNSSSSAGELLEAANIWRFPEYASSQLYMEEPTGGAAACMQLFNDYLNMN
What is the function of this protein?
Required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis.  Involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea.  Regulated by transcription factor esg.  The longer hdc protein is completely functional and the shorter protein carries some function.
What are the official names of this protein?
Headcase protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_ALKCK
Sequence: MSRMACKLSYDGTAFAGYQVQPGKRTVQSEVERALQEIHKGARVPVVASGRTDAGVHACGQVLHFDTELTIAPERWVSALNTHLPDDIVVTNAAMVEPDFHARYGAQAKEYRYYIQCGPFENVFRRHFAVHIKQALDVPAMQTAAKHLLGTHDFSAFCAANTTVTDKVRTITHVAVQPSEEGLLISIRGTGFLYNMVRIIVGTLLEIGTGKRVASEMKVILAGKSRNLAGKTAPAHGLCLYEVDYGQPLFVNETPGQVSMN
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: HIS2_PSEE4
Sequence: MSDTLNRLAEVLEERKQAAPDSSYVASLYHKGLNKILEKLGEESIETIIAAKDAATSKDYSDVIYETADLWFHSLVMLSALGQHPQAVLDELERRFGLSGHDEKAARQPSA
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUCL_MESAU
Sequence: MVKLAKAGKTHGEAKKMAPPPKEVEEDSEDEEMSEEEDDSSGEEVVIPQKKGKKATATPAKKVVVSQTKKVAVPTPAKKAAVTPGKKAAATPAKKAVTPAKAVATPGKKGATQAKALVATPGKKGAVTPAKGAKNGKNAKKEDSDEDEDDDDDEDDSDEDEEDEEEDEFEPPVVKGKQGKVAAAAPASEDEDEEEDEEEEEEDEEEEDDSEEEEAMEITPAKGKKAPAKVVPVKAKNVAEEDDDDEEEDEDEEEDEEEEEDEEEEEEEEEEEPVKPAPGKRKKEMTKQKEVPEAKKQKVEGSESTTPFNLFIGNLNPNKSVAELKVAISEPFAKNDLAVVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFEDALEIRLVSQDGKSKGIAYIEFKSEADAEKNLEEKQGAEIDGRSVSLYYTGEKGQRQERTGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQQGKSKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFEGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGGRGGFGGRGRGGFGGRGGFRGGRGGGGGGGDFKPQGKKTKFE
What is the function of this protein?
Nucleolin is the major nucleolar protein of growing eukaryotic cells.  It is found associated with intranucleolar chromatin and pre-ribosomal particles.  It induces chromatin decondensation by binding to histone H1.  It is thought to play a role in pre-rRNA transcription and ribosome assembly.  May play a role in the process of transcriptional elongation.  Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
What are the official names of this protein?
Nucleolin, Protein C23.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: MURC_ECOLU
Sequence: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLMNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKLKPQTPEEAQHD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2931_ACIBS
Sequence: MKRILIVTGQSGSGKSSALQVLEDLGYYCIDNLPLALLPEIVAKLDHENNLEQLALGVDVRSTRADMQEFDHVFEQLQKHGTVDVIYLTTQDQDLIARFSASRRPHPLANRFKSLLQCIHEEKQLLIPIQFCATVHIDTTDKSVHDLKHILLSKLGQSDNLIVILQSFGYKHGIPLDADYVFDVRHLPNPHWDLELRRFSGLDEPVKQFLEASPQANEMFEDILHFLKKWLPAFAEGHRHYMTISIGCTGGQHRSVYMVDRLKQALEAEWSVQVLHREMKHWS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein ABSDF2931.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: VG49_BPML5
Sequence: MKGNQLSYDDPWSTAPAQPEPAPAPEPETAPSATVTTASAAVRDSMAVQHSTDGVSATFKFAGQYSDPWVVVKGADPADVLAKVNTAEFKALMDKVQQIAGHYAGSGGSAPANGGGGGQQQSRAPQAAQEAPGGEKRYCQHGEMVYKSGVSKKTGKPYALFSCTAPRDQQCDAQWPDKK
What are the official names of this protein?
Gene 49 protein, Gp49.
Protein: RBFA_RHOE4
Sequence: MVDPARARKLAKRIGTIVATAIDHEIKDPRLAFVTITDTKVTNDLHDATVYYTVMGEKVDSAPDVEAAAAGLEKAKGVLRSKVGAGTGVRFTPTLTFVADTVPDTARHMEELLARAKAADDEVAKARENAQPAGDADPYKEPRVASDEDEASPDVREAD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_LISMF
Sequence: MQTYNAGTFDVIVVGAGHAGVEAGLASGRMGAKTLMLTINLDMVAFMPCNPSVGGPAKGVVVREIDALGGEMGRNTDKTYIQMRMLNTGKGPAVRALRAQADKWDYQHEMKHTIEKEENITLRQGLVDRLVIEDGVCKGVITNSGAIYYAKTVVITTGTFSRGEIIVGELRYSSGPNNQQPSVKLSEHLEELGFELRRFKTGTPPRVKSSTIDYSKTEEQPGDDHPRAFSFDTVEMLLDQLPCWLTYTNETTHEIIQANLHRSPMFTATKKGTGARYCPSIEDKIVRFSDKPRHQIFLEPEGKNTEEVYVQGLSTSLPEEVQREMLRTIPGLENVEMMRVGYAIEYDAVMPDQLWPSLETKLVEGLFTAGQINGTSGYEEAAGQGLMAGINAARKVFAKEPVILGRDQAYIGVLIDDLVTKGTEEPYRLLTSRAEYRLLLRHDNADLRLTEIGHEIGLISDERYERFLAKQSAIEAEKERLQKTRIKPTAEVQAMLKEIGSGELKDGILAADLLRRPEITYDKIAQIVSRETFVTDEIAEQVEIQIKYEGYIQKSNLQVEKMKRMEDKKIPENIDYDAISGLATEALEKLKKIEPLSIAQASRISGVNPADISILLVYIEQGKIAKRDKEKA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.