PharMolix/UniProtQA huggingface dataset:
Protein: SYDP_ECOLC
Sequence: MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: COBM_MYCTO
Sequence: MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLEQIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAALKRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYLYSVARHGRYAQ
What is the function of this protein?
Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5.
What are the official names of this protein?
Precorrin-4 C(11)-methyltransferase, Precorrin-3 methylase.
What is the protein family that this protein belongs to?
Belongs to the precorrin methyltransferase family.
Protein: AMPA_PROMP
Sequence: MQFSTFQQDLNTWQGSSLIFGIVEEDLKNQLQKINFIIDSKLLLEKINQKKFNGEKGKILNFDFFDQRLQTLKIIGLGESKNINSNDIKNSLADVIRKSSDKEEKISILFPWELINSPEEIQSFGESARLSAYKDNRFNSKRDDKKVLNEIEFLNLNKFKNINFNETEYICEGVELARRLVAAPPNSLTPLEMSIQASKIAKDHGLEIKILEKNECEDLGMGAYLAVAKGSDLEPKFIHLTLKSTSPVKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPDGLEIHFIVAACENMINGSAVHPGDVIKASNGKTIEINNTDAEGRLTLADALTYASNLKPDSIIDLATLTGAIVVALGNDVAGFWTNNNMMASDLKTASSQAGEELWQMPLQKSYKDGLKSHIADMKNTGPRAGGSITAALFLEEFFDKNIKWAHIDIAGTCWTDKNRGIHPSGATGYGVKTLVQWIKNKR
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2665_CLOB6
Sequence: MHYCNKDIGSFGETIAADYIKNSGYIILERNFRCKLGEIDIIAKDKNFIVFIEVKTRYGYIYGSPSEAINFRKQNKIYKTAQLYIIKKAIHNKFYFRFDVIEVILNTLNSNYSIKLIKNAFQI
What are the official names of this protein?
UPF0102 protein CLJ_B2665.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: COX5A_SCYCA
Sequence: SHGKQETDEEFDANL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5A, mitochondrial, Cytochrome c oxidase polypeptide Va.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5A family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: CD79B_HUMAN
Sequence: MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACSRIWQSPRFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQNESLATLTIQGIRFEDNGIYFCQQKCNNTSEVYQGCGTELRVMGFSTLAQLKQRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE
What is the function of this protein?
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation.  Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
What are the official names of this protein?
B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Protein: SYK_CUPNH
Sequence: MTEPNRAQAKPAAADTPAVDENKIIAERREKLAALRQQGVPFPNDFRPTHQAAALQAQYTETEQATLEAAPVEVAIAGRMMLKRVMGKASFATVQDGSGQIQFYITRDKVGEEVYAAFKHWDLGDIISARGELFRTNKGELSVQVRELRLLSKSLRPLPDKFHGLADQEMKYRQRYVDLIVSPETRNTFRARTNAISSLRRHMADAGFMEVETPMLHPIPGGAAAKPFITHHNALDMQMFMRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTEDLIRKAAIDARGSAVLTYQDRELDLSKPFHRLTICQAIQKFAPQYTDAQLADAGFLRTELKKFGVNTNAPQFLNAGLGTLQLVLFEETAENQLWEPTFIVDYPVEVSPLARASDTVPGITERFELFITGREIANGFSELNDAEDQADRFRKQVEQKDAGDEEAMYFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPNIRDVILFPHLRRED
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_METMA
Sequence: MAYPGKKSKSYETPRHPWQEARMAAEVQLVKAYGLRNKKEVWKAASMLRMYRSEARKLLAQVASGGQEGELEGHYATQSEEILSKLIRYGIIKADANVDDILSLKTENILERRLQTQVLRLGLARTVIQARQFITHGHIAINGRKATIPGMLVSKEDEMHIGYYGSSPLMSESHSERPVQVASFLADSATTLKAAAEAKQARERPPERGGGRKKRGGRR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SIGS_STAAE
Sequence: MKFNDVYNKHHKIIHHLLKKYNISYNYDEYYQLLLIKMWQLSQIYKPSSKQSLSSFLFTRLNFYLIDLFRQQNQLKDVILCENNSPTLTEQPTYFNEHDLRLQDIFKLLNQRERLWLKLYLEGYKQFEIAEIMSLSLSTIKLIKMSVKRKCQHNFN
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival (By similarity).
What are the official names of this protein?
RNA polymerase sigma factor SigS.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: CYNS_PSESM
Sequence: MPHSNISSTPRQQLTERVLQAKAANNLTWASLAEDTGLSVVYVTAALLGQHPLPQAVAEVVAERLGLDRDAVVELQTIPLRGHVEDVSSDPTIYRFHEMVQVYGTTLKALVHEQFGDGIISAINFKLDIRKVEDPEGGERAVITLDGKFLPYKPF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: ARLY2_CHICK
Sequence: MASEGDKLWGGRFSGSTDPIMEMLNSSIACDQRLSEVDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIHTANERRLKELIGDIAGKLHTGRSRNDQVVTDLKLLLKSSISVISTHLLQLIKTLVERAATEIDVIMPGYTHLQKALPIRWSQFLLSHAVALIRDSERLGEVKKRMSVLPLGSGALAGNPLEIDRELLRSELDFASISLNSMDAISERDFVVELLSVATLLMIHLSKLAEDLIIFSTTEFGFVTLSDAYSTGSSLLPQKKNPDSLELIRSKAGRVFGRLAAVLMVLKGLPSTYNKDLQEDKEAVFDVVDTLTAVLQVATGVISTLQVNKENMEKALTPELLSTDLALYLVRKGMPFRQAHVASGKAVHLAETKGIAINKLTLEDLKSISPLFASDVSQVFNIVNSVEQYTAVGGTAKSSVTAQIEQLRELLKKQKEQA
What is the function of this protein?
Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles.  This protein may also function as an enzymatically active argininosuccinate lyase.
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase, Delta crystallin II, Delta-2 crystallin.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Protein: NAB3_YEAST
Sequence: MSDENHNSDVQDIPSPELSVDSNSNENELMNNSSADDGIEFDAPEEEREAEREEENEEQHELEDVNDEEEEDKEEKGEENGEVINTEEEEEEEHQQKGGNDDDDDDNEEEEEEEEDDDDDDDDDDDDEEEEEEEEEEGNDNSSVGSDSAAEDGEDEEDKKDKTKDKEVELRRETLEKEQKDVDEAIKKITREENDNTHFPTNMENVNYDLLQKQVKYIMDSNMLNLPQFQHLPQEEKMSAILAMLNSNSDTALSVPPHDSTISTTASASATSGARSNDQRKPPLSDAQRRMRFPRADLSKPITEEEHDRYAAYLHGENKITEMHNIPPKSRLFIGNLPLKNVSKEDLFRIFSPYGHIMQINIKNAFGFIQFDNPQSVRDAIECESQEMNFGKKLILEVSSSNARPQFDHGDHGTNSSSTFISSAKRPFQTESGDMYNDDNGAGYKKSRRHTVSCNIFVKRTADRTYAIEVFNRFRDGTGLETDMIFLKPRMELGKLINDAAYNGVWGVVLVNKTHNVDVQTFYKGSQGETKFDEYISISADDAVAIFNNIKNNRNNSRPTDYRAMSHQQNIYGAPPLPVPNGPAVGPPPQTNYYQGYSMPPPQQQQQQPYGNYGMPPPSHDQGYGSQPPIPMNQSYGRYQTSIPPPPPQQQIPQGYGRYQAGPPPQPPSQTPMDQQQLLSAIQNLPPNVVSNLLSMAQQQQQQPHAQQQLVGLIQSMQGQAPQQQQQQLGGYSSMNSSSPPPMSTNYNGQNISAKPSAPPMSHQPPPPQQQQQQQQQQQQQQQQPAGNNVQSLLDSLAKLQK
What is the function of this protein?
May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing.  Binds to poly(A)+ RNA.  Appears to act in the maintenance of CLN3 mRNA levels.
What are the official names of this protein?
Nuclear polyadenylated RNA-binding protein 3.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: PLSX_SYNP6
Sequence: MTRARIAVDAMGGDFAPEEIVKGALRAQEELQADVILVGDPDRLRAICQDHAPHLQVRIEAAEEAIAMEDAAVSVRSRPRASINVAMDLVKAGEADAVISAGHSGAVMASALLRLGRIRGIDRPAIGALLPTVIPGKPVLVLDVGANVDCKPRFLEQFAVMGSIYSRDVLGQANPRVGLVNIGEEDSKGNELALASHQLLRNNPRICFVGNAEGRDVLSGQFDVVVCDGFVGNVLLKFAEAVGSVFLEIIRDELPRGMRGKVGSTLLRRNLRRIKQRLDHAEHGGALLLGVNGICIISHGSSKAPSIYSAIRLAVEAAENRVIDHLHQIQEPPSPAADLVTEPVVS
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: PANC_CORGL
Sequence: MQVATTKQALIDALLHHKSVGLVPTMGALHSGHASLVKAARAENDTVVASIFVNPLQFEALGDCDDYRNYPRQLDADLALLEEAGVDIVFAPDVEEMYPGGLPLVWARTGSIGTKLEGASRPGHFDGVATVVAKLFNLVRPDRAYFGQKDAQQVAVIRRLVADLDIPVEIRPVPIIRGADGLAESSRNQRLSADQRAQALVLPQVLSGLQRRKAAGEALDIQGARDTLASADGVRLDHLEIVDPATLEPLEIDGLLTQPALVVGAIFVGPVRLIDNIEL
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_HAEIG
Sequence: MKTTAEIRQSFLDFFHSKGHQVVESSSLVPENDPTLLFTNAGMNQFKDVFLGMDKRPYSRATTAQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKQDAINFAWEYLTSPQWLGLPKEKLWVTVYETDDEAYNIWNKEVGVPAERIIRIGDNKGSPYASDNFWAMGDTGPCGPCTEIFYDHGDHIWGGPPGSPEEDGDRYIEIWNVVFMQFNRLADGTMEKLPRPSVDTGMGLERISAVLQHVNSNYEIDIFKTLIAKTAEIVGATDLTNKSLRVIADHIRSCAYLIADGVIPSNEGRGYVLRRIIRRAVRHGHLLGAKESFFYKLVPTLIEVMAEAGKDVKAKQTNVEKLLRLEEEQFARTLERGLSLLDEALSQVKDGILSGEVAFKLYDTYGFPLDLTADVCRERNITIDEQAFDREMEAQRTRAQAASQFGVDYNSVIRVDGETKFEGYTEVESQAKITALFYDGKSVESIEAGQSAVVILENTPFYAESGGQIGDSGYLSTQGVTFNVKDTQKYGQVFGHIGELTQGSLKVGQSVNAIVDAKRRHNTSLNHSATHLLHAALRQILGLHVVQKGSLVSDKALRFDFAQPEAITKEQLSEIETLVNQKIRANFPVQTDIMDIDSAKAKGAMALFGEKYGDKVRVLTMGDFSIELCGGIHAKRTGDIGLFKIITENAVAAGIRRIEAVTGQNAIDWLHNQQRILTQSADLLKSDVNTLAEKIQQLQDKTKKVEKELQGLKEKAAMQAGSDFVKSAVKINGVSVIAQQLDGIETKSLRVMVDDLKNQLGSGVIAFASILDKKVNLVVGVTNDLTAKIKAGELVNLMAQQVGGKGGGRPDMAMAGGSQPENVAQAIKVAQDWLNKNL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGN2_LIMKU
Sequence: MFTMKKSLLLIFFLGTINLSLCEEERNAEEEKRDGDDEMDVEVQKRFLGPIIKMATGILPTAICKGLKKC
What is the function of this protein?
Has antimicrobial activity against Gram-positive bacteria S. aureus ATCC 2592 (MIC=2. 5 uM), S. aureus ATCC 43300 (MIC=2. 5 uM) and B. subtilis (MIC=20. 0 uM), against Gram-negative bacteria E. coli ML-35P (MIC=50. 0 uM), P. aeruginosa PA01 (MIC=10. 0 uM) and P. aeruginosa ATCC 27853 (MIC=5. 0 uM) and against fungus C. albicans ATCC 2002 (MIC=5. 0 uM).
What are the official names of this protein?
Gaegurin-LK2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MFA3L_RAT
Sequence: MGLLKSHLTVCLPPSVPFLILVSTLATAKSVTNSTLNGTDVVLGSVPVIIARTDHIIVKEGNSALINCSAFGIPDLEYKWYNSVGKLLKEMDDEKERGGGKWQMLDGGLLNITKVSFSDRGKYTCVASNIYGTINNTVTLRVIFTSGDMGVYYMVVCLVAFTIVMILNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPEGQEAPDRDEVYTIPNSLKRSESPTADSDASSLHEQPQQIAIKVSVHPQSKKDHVDDQEGENLEVKDEEETEPSEEHSPETAEPSTDITTTELTSEEASPVEAPERELPPAHLETTEPAVTCDRNTCIIYESHV
What is the function of this protein?
May participate in the nuclear signaling of EGFR and MAPK1/ERK2.
What are the official names of this protein?
Microfibrillar-associated protein 3-like.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=Mainly localized in the nucleus.
Protein: COX4_NEUCR
Sequence: MLLSRTAVAVARRATAAPALRRSIATTVVRCNAETKPVPHIKRLSEIKTKDDLFGPGAAPGTVPTDLEQATGLERLEILGKMEGVDVFDMKPLDASRRGTMENPISVRSAGDEQYAGCTGFPADSHNVIWLTMTRERPVERCPECGNVYKMDYVGPQDDHAHDHGHDHHGFEEPKTFADYVKPEYW
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 4, mitochondrial, Cytochrome c oxidase polypeptide IV, Cytochrome c oxidase subunit Cox4.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5B family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: NFUA_SALCH
Sequence: MIRISDAAQAHFAKLLANQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEATDTALKFDLLTAYVDELSAPYLEDAEIDFVTDQLGSQLTLKAPNAKMRKVADDAPLMERVEYALQSQINPQLAGHGGRVSLMEITDEGYAILQFGGGCNGCSMVDVTLKEGIEKQLLNEFPELKGVRDLTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: G6PI_BURL3
Sequence: MTLNSLPAWTALQSHFEQIRHARLRDWFAPENDHTPTRAERFTIPGGGIAADFSKNRINDDTLRLLVQLARDAGVEARRDAMFAGEIVNPTEGRAALHTALRATDPQAPFHAQISAERAKMATFARAVRSGTWTGYTGKRIRHVINIGIGGSDLGPKMVVHALHHVATPEITTHFVSNVDGADLARVLEQVDPEETLAIIVSKTFTTLETMTNARSLRDWFVARGCPEDALAKHFVGVSANPAEVVKFGIAADNVFEMWDWVGGRYSLWSAVGLSIMIAIGPEQFDELLAGANDMDRHFREAPLERNLPVLLGLIGIWYRNFFGSQSYLVAPYSEALHYLPSYLQQLEMESNGKSARLDGTFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFIAVLTPEHPLASHHPKLLANCFAQSEALMLGRTLDEARKVAGPGKEALAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEHKVLVQATVWDINPFDQWGVELGKILGKVVEADLSAESIDPAKHDSSTTALIERARAALKR
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_CHESB
Sequence: MRCPYCQSEDTQVKDSRPAEDGAAIRRRRACPVCGGRFTTFERVQLRDLVVVKRTGRKVPFDRDKLHRSFEIALRKRNVDPDRVERAVTGIVRQLESFGENEISTDDIGLLVMEALKSLDDVAYVRYASVYRNFREAKDFQDVLGELRGEPELE
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: MSRQ_XANOR
Sequence: MAKTSTSVIVAKTLVHAAALAPIALLGWQFWQVWQSGSDALGADPVAEIEHRTGLWALRFLLITLAITPLRQLTGQAVLIRFRRMLGLYAFFYATVHLAAYLTLDLRGFWTQIFEEILKRPYITVGFAAWLLLMPLAITSTQGWMRRLKRNWGRVHMLIYPIGLLAVLHFWWLVKSDIREPALYAGILAVLLGWRAWKKLSARRTKARRSAPPQATPR
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPT8_YEAST
Sequence: MDEVDDILINNQVVDDEEDDEEMLSGLENDSKQDLEGNDDGGEDEEDDDDDDEDDDDDEDEREDDDEQEDDDGEDDAARMDKTATPTNEHQHDEQKAAAAGAGGAGDSGDAVTKIGSEDVKLSDVDGGVGSREASSSTHEASANGEVYEYYKHMLNAAQIADSYNIYPTAAIPIQTHVNALAVSRGLKYLFLGGSDGYIRKYDLLNTLEGKLSLTILQKHSLAESIQNAGILQSYWENEIPQKKSEMKLSANKTDYEPKVSPVHSLEVQSECLFILSGLQNGGITMQGVRYMEGSIAHYFKGRNGHTQIVNILRLNGQEDRFLSGSWDKRLLEWDLQTGDIVNEFKKSRSELSSLEMRPLYSSVDVSGNVNSGKENENADDDMDSLFGDEDEDEKQDAGNEPVETGDGSNGEENKEQISEESLNIVYDESVFMTSGLNGSVHIWDRRMTQSPALSLERGAGVPPWCLSACWGVDGDHVYAGRRNACVEQFDLKMPSKPIHNLKLPSISGPVSCVKAMPNNKHLLCASRDNIRLYNVEIAVDASNSTTKSSKVPFLIVPGHHGGIISNLYLDPTSRFIISTSGNRGWQGNSTDTTLIYDIDLE
What is the function of this protein?
Required, directly or indirectly, for TATA-binding protein function at particular promoters.  May promote a functional interaction between SPT3 and TATA-binding protein.  Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA.  SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes.  At the promoters, SAGA is required for recruitment of the basal transcription machinery.  It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8).  SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac).  SAGA interacts with DNA via upstream activating sequences (UASs).
What are the official names of this protein?
Transcription factor SPT8.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SPT8 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAPSD_APRVF
Sequence: MRPIRMYKNNQERTTTKHQETIEDNQNEQTTSDQRFTRSSNSGKINVERISSSRHQIADGKTMSSYTTNEANYTSKDSVQHGGSSITYTSNTTGNPRVTNARANIDETYATGTVEDLSSTSHGQEPEIESFADRAELAMMIQGMTVGALTVQPMRSIRSTFANLANILIFHDVFATEDKPTSSIEYHSDEMVVNMPKQTYNPIDTVAKILYLPSLEKFKYGTGIVQMNYSSNVSQLFPNTTNIINTITDGLTYANRTEFFIRVMVLFMMDRKILTMDFYDVDASAISNNAILPTIPTITGVSPLLRIDTRTEPIWYNDAIKTLINNLTIQYGKIKTVLDANAVKRYSVVGYPIDQFRAYLYNHNLLEYLGKKVKREDIMSLIKALSYEFDLITISDLEYQNIPKWFSDNDLSRFVFAVCMFPDIIRQFHALNIDYFSQANAFTVKSENSIIKMLNSNQNMEPSIINWFLFRICAIDKTVIDDYFSLEMTPIIMRPKLYDFDMKRGEPVSLLYILELILFSIMFPNVTQHMLGQIQARILFICMYAFRQEYLKFIAKFGFFYKIVNGRKEYIQVANQNERMSENVDVLTGNLYPSLFTDDPTLSSVAPTLAKIARLMKPTTSLTPDERAISAKFPRFKDASHLNPYSSLNVGGRTQHSVTYTRMYDAIDEMFNLILKSFANNFAQRPRAGVTQLKSLLTQLTEPLCLELDGHVYHLYNVMANMMQNFIPNTDGQFHSFRACAYAVVDSGNIYRVVQNGDELNESLVIDTAIVWGLLGNTDNAYGNAIGATGTANVPTKVQPVIPTPDNFITPTIHLKTSIDAVCSVEGILLLILSRQINIPGYEVELDKLRIGISQPKVSERQYQRARESIKNMLGSGDYNIAPLHFLLHTEHRSTRLSKPLIRRVFDNVVQPYVANLDPAEFENTPQLIESSNMTRLQIALKMLTGDMDDIVKGLILHKRACAKFDVYETLTIPNDVQTIVLTMQHISTQTENNIVYYVFLINGVKIFAEDVKNINFQVDTTGIWPEHVVTLLLRAINNGFNTYISMPNILYKPTITADVRQFLNTTKAEVLLVSNRSVIHEIMFFDNALQPKKSSDTLALSEAVYRTIWNSSVITQRILARGLMNLEDNKPPEAKISQQSELDMGKIDETSGEPIYTSGLKKMDSSKISMFNVVLSAGSDVIRQAAIKYSAVRTQEVILFE
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a pseudo T=2 symmetry, about 60 nm in diameter, and consisting of 120 capsid proteins.  The capsid encapsulates the genomic RNA (By similarity).
What are the official names of this protein?
Putative major capsid protein VP3.
What are the subcellular locations of this protein?
Virion.