PharMolix/UniProtQA huggingface dataset:
Protein: SIDL_ASPFU
Sequence: MRNTICRLPNGQSYTVTPVFGGVNFKSNDMHLKDSIIPPGWTIVLYTNQNTDQPAQDSVPPEEERGRSRYTQGEAEEKTRTTRFTTPTLNDDCFYISFIVNPPSTDFKPPVSPTRQIAMMIWVSLYWYFHEPEPDLHLQTDAASQTPLTGKPKGEWRIHLKREGIFKGRNLLQKLERMGLIASEESSVGLEPSETQESGAWSRMFVSRRSFWQIDPRIFVFTLVPANPLHSAPSSPFISPRFASPSRESPIPTESPASPTGKDFPLHMPNEGPFASSSHLPTYFPPPPTQYTFTNGLRHPVRPKPPHQGEVFYIRFIPSVGQYLSFRVPILSSSATPSRGHGHSHSTSSIEVPPQTTPSDLDLLHKWMNDPRVSAAWGEGGPKEKQEKFLRNNLTSRHSFPVIGCWDGKPFGYFEIYWVKEDRLGALIGGADNYDRGIHLLVGEQEYRGSHRVAIWLSALVHYCWLADPRTQTVMLEPRVDNEK
What is the function of this protein?
Acyltransferase; part of the siderophore biosynthetic pathway (PubMed:21622789).  Aspergillus fumigatus produces 4 types of siderophores, low-molecular-mass iron chelators, including excreted fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake and intacellular ferricrocin (FC) for hyphal and hydroxyferricrocin (HFC) for conidial iron distribution and storage.  TAFC consists of 3 N(2)-acetyl-N(5)-anhydromevalonyl-N(5)-hydroxyornithine residues cyclically linked by ester bonds; FC is a cyclic hexapeptide with the structure Gly-Ser-Gly-(N(5)-acetyl-N(5)-hydroxyornithine)x3.  The biosynthesis of all four siderophores depends on the hydroxylation of ornithine, catalyzed by the monooxygenase sidA (PubMed:15504822, PubMed:16113265).  Subsequently, the pathways for biosynthesis of extra- and intracellular siderophores split (PubMed:17845073).  For biosynthesis of extracellular siderophores, the transacylase sidF transfers anhydromevalonyl to N(5)-hydroxyornithine (PubMed:17845073).  The required anhydromevalonyl-CoA moiety is derived from mevalonate by CoA ligation and dehydration catalyzed by sidI and sidH respectively (PubMed:22106303).  The acetylation of N(5)-hydroxyornithine for FC biosynthesis involves the constitutively expressed sidL (PubMed:21622789).  FC is hydroxylated to HFC by an as yet uncharacterized enzyme during conidiation (PubMed:17845073).  Assembly of fusarinine C (FsC) and FC is catalyzed by two different nonribosomal peptide synthetases (NRPS), sidD and sidC respectively (PubMed:17845073).  Subsequently, sidG catalyzes N2-acetylation of FsC for forming TAFC (PubMed:17845073).  Both extra- and intracellular siderophores are crucial for growth during iron limitation and virulence (PubMed:16113265).
What are the official names of this protein?
Acyltransferase sidL, Siderophore biosynthesis protein L.
What is the protein family that this protein belongs to?
Belongs to the lysine N-acyltransferase mbtK family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RSGA_YERPB
Sequence: MSKNKLSKGQQRRVQANHQRRLRTDRKPELDDSQLGDAQEGIVISRFGQHADVEAVDGTQHRCNIRRTIKSLVTGDRVVWRPGLQAQEGVRVKGIVEAVHERTSVLTRPDLYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLEVEPLIVLNKIDLLDADGRKFVDGMMDIYRRIGYDVLEVSSQTREGMEAFENALTGRISIFAGQSGVGKSSLLNALLPPTDNEILVNTVSGNSGLGQHTTTAARLYHFQHGGDVIDSPGVREFGLWHLAPEQITQGFVEFRDYLGHCKFRDCSHTNDPGCALREAVEQGKIAEERFDNYHRILESMEQAKPRKTSDSDEK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_MYCMS
Sequence: MAKSRILKGDVVKVIAGSHKGQIGPITSITKDKQWVSVQGITVKKHVKPTNEDSEGGIKDIPAKLHISNVALQDPKNKDQVTKVGFEIINGKKVRIARKSKTQIKTAK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: ZAPD_ECO81
Sequence: MQTQVLFEHPLNEKMRTWLRIEFLIQQLTVNLPIVDHAGALHFFRNVSELLDVFERGEVRTELLKELDRQQRKLQTWIGVPGVDQSRIEALIQQLKAAGSVLISAPRIGQFLREDRLIALVRQRLSIPGGCCSFDLPTLHIWLHLPQAQRDSQVETWIASLNPLTQALTMVLDLIRQSAPFRKQTSLNGFYQDNGGDADLLRLNLSLDSQLYPQISGHKSRFAIRFMPLDSENGQVPERLDFELACC
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: PDRP_RICPR
Sequence: MTKLIIHLVSDSSVQTAKHAANSALAQFTSIKQKLYHWPMIRNCELLNEVLSKIESKHGIVLYTIADQELRKTLTKFCYELKIPCISVIGKIIKEMSVFSGIEIEKEQNYNYKFDKTYFDTLNAIDYAIRHDDGQMINELSESDIILIGPSRTSKTPTSVFLAYNGLKAANIPYVYNCPFPDFIEKDIDQLVVGLVINPNRLIEIREARLNLLQINENKSYTDFNIVQRECIEVRKICNQRNWPVIDVSTRSIEETAALIMRIYYNRKNKYHK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: SECA_ACISJ
Sequence: MATNFLTKIFGSRNDRLLKQYRKTVARINAMEPDYEKLSDEALRGKTQEFKDRIAQGESLDALLPEAFAVVREGSKRIMKMRHFDVQLVGGMALHYGKIAEMRTGEGKTLTATLPVYLNALSGQGVHVVTVNDYLAGRDAQWMGRLYNFLGLTVGINLPQMPREEKQAAYQADITYGTNNEYGFDYLRDNMVYDARERVQRGLNYAIVDEVDSILIDEARTPLIISGQAEDHTALYVAMNKVVPLLVRQEGEADPRTGEGVTKPGDFTLDEKTHQVFLTEQGHENAERILASQGLIPEGASLYDPANITLVHHLYAALRANHLYHRDQHYVVQNGEIVIVDEFTGRLMAGRRWSEGLHQAVEAKEGVNIQAENQTLASITFQNYFRLYNKLSGMTGTADTEAYEFQEIYGLETVVIPPNRPSKRDDQLDRVYKTTREKYEAAIADIRECHERGQPVLVGTTSIENSEIIAELLNKAGLPHQVLNAKQHAREADIVAQAGRPGMITIATNMAGRGTDIVLGGNVEKAIAALEADESLSEADRAARVQELRAQWKLDHEKVTALGGLRIIATERHESRRIDNQLRGRSGRQGDPGSSRFYLSLDDQLMRIFAGDRVKAIMDRLKMPDGEAIEAGIVTRSIESAQRKVEARNFDIRKQLLEYDDVANDQRKVIYQQRNEILDAPDLGVLIDAMRDDCLADVVRQYVPAESVEEQWDLAGLEKALASDWQVSLALQKEVEGSDAITDEEILEKVQQAAREAFQAKVGQVGAENFTQFERMVLLQNFDTNWRDHLSALDYLRQGIHLRGYAQKQPKQEYKREAFELFRQLIDQVKNEVTRLMMTVQVQSSAQLDEATQAMEDRGEGISNVTYSSPTETGEVETVADAATAAQPAAAGVRVGRNDPCPCGSGKKYKQCHGKLA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: TI214_CHLSC
Sequence: MILKSFLLGNLLSLCMKIINSVVVVGLYYGFLTTFSVGPSYLFLLRARVMEEGTEKEVSATTGFITGQLMMFISIYYAPLHLALGRPHTITVLVLPYLLFHFFWKNHKHFFDYGSTTRNSMRNLSIQCVFLNNLIFQLFNHFILPSSTLARLVNIYMFRCNNKMLFVTSSFVGWLIGHILFMKWVGLVLFWIRQNNSIRSNVLIRSNKYLVSELRNSMARIFRILLFITCVYYLGRIPSPIVTKKLKETSETEEGGESEEETDVEIETTSETRGTQKEQEGSTEEDPSLCSEEKEDPDKIDETEEIRVNGKEKTKDEFHKHRPVYENSYLDGKKKIENWELGILKEDKDLFWFEKPLLTLLFDYKRWNRPLRYIKNDRFENAVRNEMSQYFFHTCPSDGKQIISFTYPPSLSTFLEMIQKKMSLCTTKPEPEDLYNNWIYINDQKINLNNEFINRIEALDRGSLAMDILEKRTRLCNDENEQEYLLEMYDPLLNGPYRGTIKKCNSRSIKDDSITPTEDSIKRIWINNIYGILSTDYREFEHKIDLFDRESLSTDIGHSLTLIIGHSLPAISKFAGESEPSLNFKRLALLAEQRRIDSENKEKCLQLLSEENTTHPNDQTIRNQSIGIEEIGKRVPRWSYKLTDDFEEQEEEDEEESTEDHEIRSRKAKRVVIYTDNDENTDTDTSTKDTTNSDRAEEVALIRYSQQSDFRRNLIKGSMRAQRRKTVTWEMFQANVHSPLFLNRIDRTSPFFSFDFDIAQIMKPLLRNWMENEPEFKTSDSEEKEAKEEEKQKKEKQEADERIFIAEIWDTIIFAQAIRGSMLVTQSILRKYIVLPSLIIAKNIGRMLLFQFPEWYEDLKGWNKEMHIKCTYNGVQLSETEFPKDWLTDGIQIKILFPFCLKPWRRSKLKLRSHHEDPLTLKKKGKKENFCFLTIWGMETELPFGSPRKQPSFFEPISKELEKIIRKVKRKFFLVLRVFKERTKWFLKLSKEKAKWVVLFIKRILKEFEKVNPISLFGLMKVHEPSEKGKDCIISNKIAHESPIQIRSMDWTNYSLTEQKMKDLANRITTIRNQIEKITKEKKKRFLTPDINISPNEIGCDDKRSESQKHIWQISKRRSAKLIRNWPYLMKSFIERIYIDIFLCTINIPIINAQLLLESTKKIIDKYIYNDETNQEGIDETNLNIIHFISTIKKSLSNTNISNKNLQIYCDLSSLSQAYVFYKLSKIKVINLYRLGSALQYHETYLFLKDRIKDYCGTQGIFDSESRHKKPQNSGMNEWKNWLRGHYQYKLSQTKWSRLVPRKWRNRVNQRRMIPNKDSKKWNSYEKEKDQLIHYDKKNDSAVDSLPSQKEKFKKHSRYDLLSHKYIIYEDGKDSSIYGSLLQVNRNQEIPYNYKTHKPKPFYVPGGIAISDYLGEEYIIDIDTDQNPDRKYFDWGILRFCFRKNNINIEPWTDMDSGTNNYQITDKKDLFSLTIHQEINPSTSNSNQKKNFFDWMGMNEEMLSRPISNLEPWFFPEFVLLSDAYKVNPRTIPIKLLLFNFHENENIQNENISENKNINGNKKKDFRISSNQKEYLDQNHEEKELLGQEDCGSDPRNQQKYIEEDYTGSDIKKRRSRKKKLSKSNEEVELDFFLKRYLFFQLRWDYSLDQRIINNIKIYCLLLRLINPNEIAISSIQKGEMFLDVMAIQKDLAFTELRKKGIFIIEPLRLSIKWDGPFYMYQTVGISLVHKSKHQINRRYREKRYVDQNHFNRSTAQHGKILVNGDENHYDLLFPEKIPSTRRRKEMRILISFNSGNGNVVNRNPVFLNGNNVRNCSQFFDEDKHFDTNKFMKFKFFLWPNYRLEDLACMNRYWFDTNNGSRFSMLRIHMYPRFIIS
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: SYD_LISIN
Sequence: MEKRTSYCGELNETHIGQSVILHGWVQKRRDLGGLIFIDLRDREGIVQVVFNPEFSKEALEIADSVRNEFVVTIKGKVHARGEKAINDKLATGKVEVLAEEITILNTSKTPPFYIEDGVNVSDELRLKYRYLDLRRPEMNNIFKMRHTVTRTFRNKLDALGFFDIETPYLTKSTPEGARDYLVPSRVYPGNFYALPQSPQILKQLLMTAGFDKYYQIVRCFRDEDLRGDRQPEFTQIDLETSFLTKEEIQAITEDMLVDVVKEAKNITIEKPFPRMTYKEAMDRFGSDKPDIRFGLELQNVSEVVKDVDFKVFQSAIENGGEVKAINAKAAATNFSRKDLDALGVFVANYGAKGLAWLKIEAGELKGPIAKFFPEDKAAELQAALQAEDGDLLLFAADKADIVAASLGALRNKLGKDLDLINEDELAFLWVTDWPLFEYDEEAGRYVSAHHPFTLPKEEDIPFLETDSSKVMAEAYDIVLNGYEIGGGSLRIYKKEVQESMFRALGFTDESAKEQFGFLMEALEYGTPPHGGIALGLDRIVMILAGRNNLRDTIAFPKTGSAVDPLTNAPGEVSAAQLAELKLETVKKETN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_OENEH
Sequence: MRINPTTSGPGVSTLEKKKSGRIAQIIGPVLDVTFPPGKMPNIYNALVVKGRDTGGQEINVTCEVQQLLGNNRVRAVAMSATDGLTRGMEVIDTGAPLSVPVGGATLGRIFNVLGEPVDELGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQNVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKAGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGDEHYETAQRVKETLQRYKELQDIISILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFKLILSGELDGLPEQAFYLVGTIDEATAKAANLEMESDLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RL13_HCMVM
Sequence: MHWHLAITWTVIILTFSECYNQTCPCPCICVNSTTVSISTSETTSKNITPTTTTNSKKTTSSIATTTPSLVTTGKVVSTAASSTIISQTNRSHTSNAITTPKTRFEYNITGYVGQEVTLNFTGSWNYIQWFRYGSPGWLYSSEPICTVTSNYHHTFPRGALCFDCDMTKLLIYDLTLNDSGKYVVKRTRHDNQYEEACYSLTVIFANTTSIVTNRTCDRKRTENTDTTNHEIGKHIIETIKKANIPLGIHAVWAGIVVSVALIALYMGNRRRPRKPRYTRLPKYDPDESWTKT
What is the function of this protein?
May play a role in modifying tropism or in modulating cell signaling during virus entry.  Since RL13 expression severely impairs HCMV replication in epithelial cell cultures, it may act as a regulator promoting persistence by suppressing the switch to fully lytic infection.
What are the official names of this protein?
Membrane protein RL13.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: NU2M_APILI
Sequence: MFFMNFKYHWFIYFLITIFVLMMNSNNIFIQWMLMEFGTIISISLINIKSTNKTPSLIYYSVSVISSIFLFFMIIVYLSSISFTKTDTFNFMVQMMFFLKIGTFPFHFWMIYSYEMMNWKQIFLMSTLIKFIPIYMMVSMTKINSWTLYFLITNSLYISFYANKFYTLKKLLACSTIFNSFYFIFILELNKNMFIAMIILYSFNYFLLISFLNKFNIQNFNFMFYNKYQMYTFLTLMFNYSMYPIFLSFVIKWNLIFMMVSVKAYNWILFLLMISSMLMIWNYIIILKRVFLKMNFYKNNFIDDKDNKYMYHSYFALTLLSFNISFFITLNFL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPOC_FINM2
Sequence: MVQKNTFEAMKIGLASPDKIRQWSWGEVKKPETINYRTLKPEKEGLFCEKIFGPTKDYECNCGKYKRIRYKGIVCEKCGVEVTKSKVRRERMGHIELATPVSHIWYFKGIPSRMGLLLDMSPRALEKVLYFASFVVIDPGKTDLYEKQLLTEQEYEEYCDKYEEDVDFRAKMGAEAIKELLQKIDLQEEYKNLTETFEGSTGQKKVRILRRLEVVEAFIESKNDPSWMIMDVIPVIPPDIRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLDIGSPEIIVRNEKRMLQEAVDALIDNGRRGKPVTGPGNRPLKSLSDMLKGKSGRFRQNLLGKRVDYSGRSVIVIGPNLKFYQCGLPKKMALELFKPFVIRELVKREISHNVKNAKKLVERENDKVWDVLEDIIVDHPVLLNRAPTLHRLGIQAFEPILVEGKAIKLHPLVCTAYNADFDGDQMAVHLPLSPEAQAEARLLMLSTNNILAPKDGKPITTPSQDMVLGSFYMTTRKEGQKGEGLIFKDIDEMMLAYAMHYVTLQTIVKVRRNSVNNDGTSKIVESTVGRFIFNEGIPQDLGMVNRNEDPYSLEVDLQVDKKMLSKIIDLTFRRYGNIRTAELLDYIKSMGYKYSTIGALTISMGDITIPDSKKGIIEQAEQRIDMVQDIYLQGDITNEERYKKVIEIWEQCIKDVTRALMTNLPADNNLNIMAVSGARGSENQIRQLGGMRGLMSDTAGNTIEIPITSNFREGLSVQEFFISTHGSRKGLSDTALRTADSGYLTRRLVDVSQDVIITEDDCGTDEYIVAKEIKDGNRQVEDLKSRIIGRYAFEDILDLDTGEIIVHKNDMINEAIAERIESKGIKEVKVRSVLGCKMKHGVCAKCYGRNLATGKPVNIGEAVGIIAAQSIGEPGTQLTMRTFHSGGIAGVGITSGLPRVEELFEARKPKGLAYITEIEGTVKIQENKKRNDVIVTSEDGEEQVYQIPYGAHIRVNEGDHVEKGEPLTEGSINPQDILRVNGAEGVRDYIIREVQKVYRLQGVDIDDKHIEIIIRQMMSKIKVEESGDSGFLSGSVVDARDFKMTNEQLIKEGKTPATGTHSLMGITKASLATESFLSAASFQETTRVLTETSIKGKVDHLIGLKENVIIGKLIPAGTGIAKYDRIEVDYDGKAEDDMIEAEKAQASNDSEEAEESTIISGNYESLQDEDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: FTSH_ACAM1
Sequence: MPIETEPNRTRKNFEPKRFGGSLFILFTLLLFLNLFVLRGPRFPITAYSDFITQVEAGQVERVEVRPDRIRYILKSDQYGFNEGTETAAVFDTVPVGIDLELPKFLREHDVQYFAPPPSSLSWLPTLLGWVVPPLIFFGIWSWLINRNQGAGPAALTVGQSKARIYSEGSTGVTFDDVAGVEEAKTELLEIVDFLAHADKYTRLGAKIPKGVLLVGPPGTGKTLLAKAIAGEAKVPFFSISGSEFIELFVGIGAARVRDLFEQAKQQAPCIVFIDELDALGKARGGPGGFTGGNDEREQTLNQLLSEMDGFDPNVGVILLAATNRPEVLDPALLRPGRFDRQIVVDRPDKMGREAILKVHVRGVKLAEDINLTKLAVRTPGFSGADLANLVNEAALLAARQSRDAVVMSDFNEAIERVVAGLEKKSRVLNDLEKKTVAYHEVGHAIVGSLMPGAGTVEKISVIPRGIGALGYTLQLPEEDRFLITASELRGRIATLLGGRSAEELIFGVVSTGASDDIQKATDLAERYVTLYGMSDELGPIAYEKAQQQFLEGVPNPRRTVGPQVVEAIDQAVKDVVDGAHHMALSILSINQDMLQLTASHLLEKEVLESQELHSLLSQPQFPPDMDEWLQTGKLPQGKELIQTTLNSHQLIGIN
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein; Stromal side.
Protein: RS10_THEP3
Sequence: MPKQKIRIRLKAFDHAILDQSAQKIVETAKRTGAEVSGPIPLPTEKDIITILRAPHKYKDSREQFEIRTHKRLIDILNPTPKTVDALMRLDLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ATP9_DICCI
Sequence: MKNIVKIEQLELASAVVELGKKVGAGLAAIGLTGAGAGVGIVFAAFILAVGMNPNLRGELFKLAMLGFALSEAVGLLALMMSFLILYS
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  A homomeric c-ring of probably 10 subunits is part of the complex rotary element (By similarity).
What are the official names of this protein?
ATP synthase subunit 9, mitochondrial, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: LARG2_MOUSE
Sequence: MLPRGRPRAMGAAVLLLLLLLVVGFFLFGRDPDYGLGTTATLDEDPYRSRNLSASSPQLLLPPKCEMLHVAIVCAGYNSSREIITLTKSLLFYRKNPLHLHLITDAVARNILETLFRTWMVPAVVVSFYDAEELKPLVSWIPNKHYSGLYGLMKLVLPSILPPSLARVIVLDTDVTFSSDIVELWALFDHFSDKQVVGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLWLDRLQQTGWEQMWKVTAKRELLTLMATSLADQDIFNAVIKEHPHLVHPLPCVWNVQLSDHTRAERCYLEAADLKVIHWNSPKKLRVKNKHAEFFRNLHLTFLGYDGKLLRRELFGCPNQFPPGAEQLQQALTQLDEEEPCFEFRQQQLTVHRVHITFLPHQPPPPQPHDVTLVAQLSMDRLQMLEALCRHWPGPMSLALYLTDEEAQQFLHFVETSPVLSMRKDVAYHVVYRDGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLELDSRRKTALVVPAFETLHYRFSFPNSKAELLTLLDAGSLHTFRYHEWPQGHSSTDYSRWREAQAPYSVQWSADYEPYVVVPRDCPRYDPRFVGFGWNKVAHIIELDAQEYEFLVLPEAFSIHLPHAPSLDISRFRSSPTYRNCLQALKEEFHQDLSRRYGSAALKYLTALQQARSRA
What is the function of this protein?
Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner (PubMed:15958417, PubMed:23125099, PubMed:23135544, PubMed:25138275).  Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:23125099, PubMed:23135544, PubMed:25138275).  Supports the maturation of DAG1 more effectively than LARGE1 (By similarity).  In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (PubMed:27496765).
What are the official names of this protein?
Xylosyl- and glucuronyltransferase LARGE2, Glycosyltransferase-like 1B, LARGE xylosyl- and glucuronyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: SYM_SYNY3
Sequence: MLDSSVPTFSVTTPLYYVNDVPHLGSAYTTVVADTLARFKRLQGYDVLMITGTDEHGQKIQRTAEAQELDPQTHCDRTVVKFKELWRSLNILYDRFSRTTDPRHLAIVKDFFQRVWDKGDIYLAQQQGWYCVACEEFKEKRDLLEDNHCPLHPNRKAEWRDEENYFFRLSRYQHPLEELYAQRPEFIQPSSRRNEVLNFVAQGLQDFSISRVNLDWGFPLPNDPNHTIYVWFDALLGYVTALLDEDEEPNLTNALVKWWPINLHLIGKDILRFHAVYWPAMLMSAELAIPAQVFGHGFLTKDGQKMGKSLGNTVDPLDLINRYGEDAFRYYFLKEIEFGKDGDFNEQRFVNVLNADLANDLGNLLNRTLGMVKKYCQGQGPQVMATDLAPDNPLKALGSHLGEEVSSAYERLSFTDACEAIFTLVRAGNKYIDDMAPWKLFKQGSQKEVEDVLYSVLESIRLSAYLLSPIVPRLSTKIYQQLGFTWDFDQWRSPLEQAEEFNRHQSWGQLGANQNLPPAQPIFTKLELPAEE
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_PECCP
Sequence: MANIKSAKKRAVQSEKRRKHNASRRSMMRTFIKKVYAAIATGDKEVAQKAFNDMQPIVDRQAGKGLIHKNKAARHKSNLVARINAMQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: IL1A_BOVIN
Sequence: MAKVPDLFEDLKNCYSENEDYSSEIDHLSLNQKSFYDASYEPLREDQMNKFMSLDTSETSKTSKLSFKENVVMVAASGKILKKRRLSLNQFITDDDLEAIANNTEEEIIKPRSAHYSFQSNVKYNFMRVIHQECILNDALNQSIIRDMSGPYLTATTLNNLEEAVKFDMVAYVSEEDSQLPVTLRISKTQLFVSAQNEDEPVLLKEMPETPKIIKDETNLLFFWEKHGSMDYFKSVAHPKLFIATKQEKLVHMASGPPSITDFQILEK
What is the function of this protein?
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems.  After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex.  Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.  In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways.  Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.  In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
What are the official names of this protein?
Interleukin-1 alpha, IL-1 alpha.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Recruited to DNA damage sites and secreted after genotoxic stress.