PharMolix/UniProtQA huggingface dataset:
Protein: RLF35_ARATH
Sequence: MAAHKMSLTSLFFVSIVIVLSLFSGFGEGRYIKYRAIAKDRVPDCTQDPKNCVRVPVNQYHLPPGCQNTTHCYREKYHI
What is the function of this protein?
Cell signaling peptide that may regulate plant stress, growth, and development.  Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
What are the official names of this protein?
Protein RALF-like 35.
What is the protein family that this protein belongs to?
Belongs to the plant rapid alkalinization factor (RALF) family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEBP1_PIG
Sequence: MLGMIKNSLFGSVETWPWQVLSKGDKQDISYEERACEGGKFATVEMTDKPVDEALREAMPKVMKYVGGSNDKGIGMGMTVPISFAVFPSDGGSLQKKLKVWFRIPNEFQSNPPVPSDDSIKIEERESITVYSLQFGGYAKEADYVARAAQLRTALEGIATCRSDVYFCTGYDPPMKPYGRRNEVWLVKA
What is the function of this protein?
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound.  Binds with a high affinity to one molecule of heme or porphyrins.  It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity).
What are the official names of this protein?
Heme-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the HEBP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL2_HPV48
Sequence: MSLRRRKRASPTDLYKTCLQGGDCIPDVKNKFENSTIADWLLKIFGSLVYFGNLGIGSGKGSGGSFGYRPLGSAGSGRPATDLPVTRPNVVIEPIGPQSIVPIDPGASSIVPLVEGGPDISFIAPDAGPGIGGEDIELFTFRDPATDVGGVSGGPTTISTEESETAIIDALPSATTPKQLFYDSYTQTILQTQVNPFLNNAISDTNVFVDPLFAGETIGDNIFEEIPLQNLNFSFPRESTPVKPGRGLRTPAQRSYSRFMEQYPIQAPEFLSQPSRLVQFEFENPAFDPDISIQFQRDVNSLEAAPNPAFADIAYLSRPHMSATSEGLVRVSRIGSRAVLQTRSGLTIGPKVHYYMDLSAISTEAIELQTFADSGHVHTIVDDFLSVTALDDPANIADINYTEDDLLDPLLENFNNSHITVQGVDEEGETVALPIPSITNSSKTFVTDIAENGLFANDTDSLLTPASTIVPAINWFPLFDSYSDFALDPFFIPRKKRRLDIL
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: AKIR1_HUMAN
Sequence: MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGSSWMKKDQPTFTLRQVGIICERLLKDYEDKIREEYEQILNTKLAEQYESFVKFTHDQIMRRYGTRPTSYVS
What is the function of this protein?
Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (By similarity).  Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis (By similarity).  May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (By similarity).  In contrast to AKIRIN2, not involved in nuclear import of proteasomes (PubMed:34711951).
What are the official names of this protein?
Akirin-1.
What is the protein family that this protein belongs to?
Belongs to the akirin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIOF_MYCLE
Sequence: MKVPIETSPLAWLEAVEQQRRGAGLRRSLRPRSAVATELDLASNDYLGLSQHPDVIDGGVAALRVWGAGATGSRLVTGDTILHHELECELAEFVGACVGLLFSSGYAANLGAVVGLSGPGSLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVDTALRSCHEERAVVVTESVFSADGVLAPVSELHDVCRRHGALLLVDEAHGLGVRGGGRGLVYEVGLAGAPDVVITTTMSKALGSQGGAVLGSSAVRAHLINTARPFIFDTGLAPAAVGAARAALQILKAETWRPEAVLQHARTLAKICDLSELPQSAVVSVVLGDPEVALAAAIACLDAGVRVGCFRPPTVPAGTSRLRLTAHASLDSAKLEVARRVLTDVLGGCCVARR
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase, Alpha-oxoamine synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: YOMH_BACSU
Sequence: MIRESQYFMFNNIPSYELGAVNVNTEGGLLEESFIANRTVNETYTRLSSEPYVDNVKLEPYEIPLNFYIENHLDEKNVRRVARWLNVDDYKPLSFSRNLDIIYFALPINATDLVHNCSNDGYVKLTMKVFPYKYGQETTTHWFDVTSGVKNIEIENIGDVDIPLSLEFKKIGDGDITVENLTLYRTPLKFTGIKHHEVINVDSNKKLITSSISGYECYDQVNEEYVILTRGKNRIKINGECYIRLKYRYKYL
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YomH.
Protein: CLPP_PELTS
Sequence: MNLVPIVVEQTNRGERAYDIYSRLLKDRIIFLGGPIDDNTANLIIAQMLFLEAEDPEKDIQFYINSPGGVVTAGMAIYDTMQYVRSPVATICIGQAASMASLLLAAGAKGKRYSLPYARILIHQPLGGVQGQATDIEIHAKEILRMRQFLNEILSRHTGQPIEKIARDTERDYFMSAQEAKEYGIIDEVYDVRK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPUB_BLAVI
Sequence: LQAPIGLHSTTAFLRALGELTGLDPEPFIEREKRTTIRPLWDLWRSMTQDFFGTSSFGIAANETYTRGLRHFLEEEMGLLCSFAFSRKPGVKPDNGAVRQAIQTSMPLIVFGRYNERMYLAEVGSRAIFIPASFPGAIVRRYTGTPVMGYAGATYVVQEVCNALYDALFNILPLGTELDKVEATPARRHKEMPWNDDARAALDDSVEALPVLIRTSAVKRLRDAAEREARAVGEERVTVACVARARAALVGGQAA
What are the official names of this protein?
Uncharacterized protein in pufB 5'region.
Protein: ARSC1_STAEQ
Sequence: MQKKTIYFICTGNSCRSQMAEGFGKLILGDKWNVYSAGIETHGVNPHAIKAMKEVGIDISHHTSDLINNDILIASDIVVTLCSDADANCPVLPKNVTKEHWGFDDPAGKDWSEFQRVRDEIKAAIETFAHRV
What is the function of this protein?
Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].
What are the official names of this protein?
Arsenate reductase 1.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC16B_BOVIN
Sequence: MEPWIPQWLPQPSGRPPAPSKDPDRGLWKDRYYQPIPHSWHNGERVHQRQDVGRSPQPQQDPREDLQEPHYAARSGEWRPPVSGVDYYEGGYPSQLYSRWSIEDLYQSYYSPALREEYAYGSYYYHGHPQQLQEERVPRQGSPYIWQEDHRDQKYLNDHQHENQNSPFGTNRETQLQSKSRNPYKDSPASNSGQERPEDLFMESPLTGAQKNKLSLMEESNLLWQHESGLTSSSYELSQYMADASELCDPMTSAVWSPVQAEDISAAGPKEPMKFYVPHMPVSFGPGGQLVCVSPSSPSDGQTALVELHSMEVILNDSEEQEEMRTFSGPLIREDVHKVDIMTFCQQKAAQSHKSETPGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDWKKLEKYKRQPPVANLINLTDEDWPVLSSGTRDLLTGEILPSVETPAQILEKFTKLLYYGRKKEALEWAMKNHLWGHALFLASKMDPRTHSRVMSGFTSTLALNDPLQTLFQLMSGRIPQAATCCGDKQWGDWRPHLAVILSNQGGDPELYQRTIVAMGDTLAGKGLVEAAHFCYLMAHVPFGYYTVKTDYLALLGSSHSQEFLKSATTEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLTSQALHYCEPVGTALLSHGESSHPVLLVELIKLAERLKLSDPLVLERRRHRGDRDLEPDWCVHLRGHHRELQQKEAGDIGRPQSAQAVISEARKTPENTFYQDLSGPQGNSEAYGDRSALWPTLEQSGPAQLSPQQPRSYPTGGGSGQMGVPVPLYSVPETHLLGTSGSMAVTGAPGGTAWEEAQQIHLPPVSPETLQHPDGQKAISRPQVPLIPRARSISESSIVSVKEDEEEPPRRQIKIFLKYRPERKPEREGDTKSSGFGWFSWFRSKPTHNASPSGEEDSSDSPDSEEMPRAASLPQPSPSLSLTPSPDPQSLLGASAFSRDTGGDEVRGSVSGVGTAEGPGSGGLSGPEGVSTELCLNAGVLLPPPSVKGSVPLYNPSQVPQLSTVTSLNRPNRLAQRRYPTQS
What is the function of this protein?
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).  Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.  Involved in peroxisome biogenesis.  Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes.
What are the official names of this protein?
Protein transport protein Sec16B, Regucalcin gene promoter region-related protein p117, RGPR-p117, SEC16 homolog B.
What is the protein family that this protein belongs to?
Belongs to the SEC16 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).
Protein: OS25_PLARE
Sequence: MNKLYSLFLFLFIQLSIKYYNAKVTVDTVCKKGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDETTVNKPCGDFSKCIKIDGSPISYACKCNPGYDMVNNVCILNECKNVTCGNGKCILDTSNPVKTGVCSCNIGKVPNADDKNKCSKDGETKCSLKCLKENETCKAVDGIYKCDCKDGFIMDNESSTCTAFSVYNILNLSLIFVLFSVCFFIM
What are the official names of this protein?
25 kDa ookinete surface antigen, Prs25.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: SYY_BORBU
Sequence: MNLALSLLHKRGFLKQCTSLKVLSDLMDREKIVFYAGVDATSSSLHIGHLIPFLAMMHLRQHGHMPIVLIGDSTAKIGDPSGKSEMRKILSSEEIGNNALLIKNQLQRITKFTSECFIHNSNWLDNLNYIEFLRDVGMHFSVNRMLSFETYKRRMDFGLSFIEFNYQLLQSYDYYMLNKIKNCRLQIGGDDQWGNIISGVDLIRKKNGSETFGLTFPLITRSDGKKMGKSEKGAVYLDSNLFSIYDFYQYFRNTSDSDVKTFLYLFTFLEEDEIELISNFKGNSLNKAKEILAFEITKIVHGEAEALKVQEASFAAFRGSGDRSNIPFFKFSFSSLKEEILLVDLMLDSKIVPSKSEGRRLIDSGGVYINGKRVESQSHLLTKKDFNNNEVELRVGKKKFLRIVI
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y483_CHLPN
Sequence: MIKKRAIFERMFPIPPPHCPPNNKNNFYHLTTDTKDPLLLRILRTIGYVLLHIITLGLLLLIHYYKHHRVVRKEGLPTPPTLPKGPEPKTIEIAKQPPKDGEDKKPDVPKPGTPPPEDTPPPPPKAPSPASPKVPKQPADKKPTPPPEAPPPPVRVATPMPLRPSSQGYWQCLNRMVSMVLRRAPLPLPAMQVDPILGDFNPHFVASYPNRIDNEPMYFQIKQFKKIAQNPDLPQQHRRLAQLSLEQALYLNDNYYLVNVPGDGNCFYRAYAVGWLSALYEESSRNDIVFEQEATRLLDLPFASSSPANANLCAEMAELLQLCSTYCSFIDLYDGVILSQKHTATLIAFLRKLSAYAIRQQIAASSNEETARALFISDMQDDLLPSVLEFLAANRPYSELFQNLIDHSALPYMQSRDKLFLLLEHLPALFLTDAELQKMSPEDQQLRKQYEREIREAFAKLSRRIADSGWDTERFNAIVKDYLPEAIRCQYSRFLATIENRRSGDLPWSPALSFFAFLCTCPSVRFHKLCATFYKSLEDIIIASAPPQRSIQEILQISNASLSYLNEDLDSSWQREVISSNIMTILTTHESLTLESSMPQLETLHKRIANLLKNVISTSFETPPLSNQPDLLSNLVNKLLVAIHSKLELKEHFNTVCSARSLRLTRDEGSGLSQEQDLLYTQAVQLLFFILQHPQVNNRPETKDAVKELKMLLLPFLQYAFKKVENEKKLQKLLRSILGSLVLKPPARYPSTPSNKDKETFCKFWSRHPEVMVLDPILEKNCMQFLRATFPNYQLETEAILLEKEIESTFRNGWNVFLTRLNLFGSKLGSPSSPTALSDQFSKSFLIFCFLNNYPKLLQKKTPLAARLDAFQREASHRFTQVKDKLLLSLKYGFPLATATINQYSRARDQLICNLLKNTVTASDGFCRSGFRQSLIGYLHSLSSNELGDILDDVKEQAEANDVAAMTTVPLQPFAVCLIMSDRDTVSEENIENFVAMHGFLNTISPERDARIFLIRFPNHYGCLLPRNPRTEDQNSKPDSSNP
What are the official names of this protein?
Uncharacterized protein CPn_0483/CP_0271/CPj0483/CpB0503.
Protein: UBE2T_DANRE
Sequence: MQRVSRLKREMQLLTAEPPPGVSCWQSEGRLDELQAQIVGGANTPYEGGVFTLEINIPERYPFEPPKMRFLTPIYHPNIDNAGRICLDALKLPPKGAWRPSLNISTVLTSIQLLMAEPNPDDPLMADISSEFKYNKPLYLEKAKKWTAEHAIQKNKGCVETDGKTPENKNLKTSHKREALSAQENLEHTKKVCL
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  Catalyzes monoubiquitination.  Involved in DNA repair.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 T, E2 ubiquitin-conjugating enzyme T, Ubiquitin carrier protein T, Ubiquitin-protein ligase T.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates to chromatin.
Protein: ATPD_PHOLL
Sequence: MSEFATVARPYAKAAFDFAVEKQSLEQWQNMLAFTAEVTRNEQVGELLSGSLASETLANTFIAICGEQVDEHAQNFIRVMAENGRLLALPEVLQQFIQLRASLESTVDVEVISATELREQQLAKISVAMEKRLSRKVKLNCKIDKSVIAGVVVRAGDLVIDGSIRGRLDRLTDVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: EMT1_USTMA
Sequence: MKVALLANPARGEINVLLATAYELIRLGHDVTFLTGSSFANAIAEFRSEQNDPILAARIHFSDLGNARAVEDFTRGMQSHLKGLRKPPGDYSSMEICQIVALVTEQEFRDAATMVRDRLLEIEPDMIAVDALSPNLVTGCRMTGLPWMFTVPCSPSLTATRKSLFDPHPMGRRRQRTLMSALENLKLTFIETYRNATKKDLYARRALLKNEFGLNSMGFNGDSAIVPPLWKDRNCVGGIHFNTPGLTDSIRQPHQIHFVGAGVTSDPENHDTPVFEAASFLKQLSPSSSTTFKPLFPPLSKTGRDLDVEWMDEAYAAGQLVVYLNMGSMFLWTDAEVRSCLRAFERLYEQSGGKIKLLFKLNKPKRTPNNTGASTPTAPISSPDFEEKQRTVMGSARPVGASNLVSEKLADAIKNVTPRRKTDADKGYSQFTLSEFEGLEYVRFTRWVHDQRSIYKHPALRVVIHHGGGNSFNEAVHYALPQMILSQWFDTHEYAILAERFGIGLRSKHAPKIDENDLVNTMTRLLQGPEAEKIRRNAKVWSIRSRNAGGAPAAARLIEAQAMLFNQQKQLELAASEVRAAVDTLSGKSSVADLESETAFTPNMLSGAASTVGSD
What is the function of this protein?
Erythritol-mannosyl-transferase; part of the gene cluster that mediates the biosynthesis of mannosylerythritol lipids (MELs), surface-active substances that enhance the availability of water-insoluble substrates (PubMed:15932999, PubMed:16885300).  Mannosylerythritol lipid production is responsible for hemolytic activity of Ustilago maydis (PubMed:15932999).  Depending on the number of acetyl groups, mannosylerythritol lipids can be differentiated into MEL A (fully acetylated), MEL B and MEL C (monoacetylated at R-6 and R-4, respectively), and the fully deacetylated MEL D (PubMed:31103599).  The first step in the pathway is the generation of mannosylerythritol by the glycosyltransferase EMT1 which catalyzes the transfer of GDP-mannose to the C-4 atom of meso-erythritol (PubMed:15932999).  This reaction has to be stereospecific, since only mannosyl-D-erythritol is generated (PubMed:15932999).  The produced disaccharide is subsequently acylated with fatty acids of various lengths derived from the peroxisomal beta-oxidation by the peroxisomal acyltransferases MAC1 and MAC2 at positions C-2 and C-3, repectively (PubMed:16885300, PubMed:24835306, PubMed:31103599).  The existence of MEL derivatives which carry an acetyl group at C-2 implies that at least MAC1 also accepts acetyl-CoA as a donor (PubMed:15932999).  The final step of MEL biosynthesis is the acetylation of the fully acylated mannosylerythritol lipids catalyzed by the acetyl-CoA-dependent acetyltransferase MAT1 (PubMed:16885300).  MAT1 displays a relaxed regioselectivity and is able to transfer acetylgroups to both positions C-4 and C-6 of the mannosyl moiety (PubMed:15932999).
What are the official names of this protein?
Erythritol-mannosyl-transferase 1, Mannosylerythritol lipids (MELs) biosynthesis cluster protein EMT1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein.
Protein: ARLY_LEPBP
Sequence: MKEKKLWGGRFDAAPSSLMIRIGESISFDQELYRHDIEGSISHSRMLRRIGILSESEQRKIETGLGQIKKEIDSGKFEFKIENEDIHMSIESRLTELLGDLGKKLHTGRSRNDQVSQDVRLYIKSEMHSILILVYDLLTVWLKKAEAHTKTIIPGYTHLQIAQPIRASHYFLSHFWANVRDFEDFYSAFERADELVLGSGALAGVNYETDREYLRKDLNLARMSENSMDAVSQRDHIFKFLFASSQFMVHASRFCEEIILYTSQEFSYFKLPDHLTTGSSIMPQKKNPDVAELIRGKAGRVIGNLTHLLVMLKGTPLSYNRDFQEDKIPLFDTVKQIKICTEGIRDMVEGIQIFPENATRSLRNGFSTATDLADWLVSAKGIPFRSAHEIVGELVKHCSMKGYDLFTIPSGERGQIHAVLTDPGYEAAISLETSCDKKDVFGGTALPRQKEQIKRAKAKLNELTKKLKQIESKGKKTI
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABA_SHESR
Sequence: MNKANSFNKEELIACGHGNLFGPNSPRLPVDNMLMIDRIITINDNGGEFGKGEIVAELDINPDLWFFGCHFISDPVMPGCLGLDAMWQLVGFYLGWEGAEGKGRALGVGEVKFTGQVLPGAKKVTYKLNIKRTIHRKLVMGIADAILEVDGRQIYSATDLKVGVFSDTSTF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPE_METNO
Sequence: MPNTPSPLALTQGLIRCPSVTPAEGGALSLLADLLGAAGFSVERPVFSEPGTPDVENLYARIGTAGPCLLLAGHTDVVPPGDLAAWRHDPFGGVVEEGEVHGRGAVDMKGGIACLAAAILAFLAERGPDFGGSIAFLITGDEEGPAVNGTVKLLAWARQKGERFDHCILAEPTNPDRLGDMIKIGRRGSLTAALTVHGVQGHVAYPHRAENPIPGLIRLAGALLAAPLDAGTAHFDASNLEFTTVDVGNPASNVIPAEARAVFNIRFNDLWTPATLEAELRRRLDAAAGNAVRYTLAVQPTNAVAFLTQPDPFVDLVTAAIEAETGRRPALSTTGGTSDARFIKDACPVIEFGLVGQTMHQIDERAALADLDRLTAIFRRVLDAYFPGDAALQKRA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: LEU1_PARPJ
Sequence: MLKNPATKYRSFKPVTLTDRQWPSRTITHPPIWMSTDLRDGNQSLFEPMDAQRKMRMFKTLVQIGFKEIEVAFPSASQTDFNFVRELIEGGHIPDDVTIEVLTQARDDLIERTFESLRGVPRAIVHLYNATAPEFRKIVFNLEKSGVKELAQNAARTMKRIAATMPETQFTFQYSPEVFSGTEIEFAKEVCDAVFDVWQPTPEHKAIVNLPATVEMSTPNIYADQIEWMHRNLARRDSLIISVHPHNDRGTAVAAAELAVMAGADRIEGCLFGNGERTGNVDLVTLALNLYTQGVDPGLDFSNINEVARTAEECTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQKPDAVWEVPYMPIDPADLGRTYDSVIRVNSQSGKGGIAYLLEQGYGVVLPRRLQVDFSSAVQRFTDDSGQEVTSAQIWELFQQEYVQNTAPIHYVGHSLSEREGRERIKLTVDIHGTRRVLTGEGNGPLDALMHAIGVPVRIQHYEERALTQGADARAVAVAEMAGADVTGSAFGVGIDANLVTASIRAVISGVNRAYARVNAQAQENFFDAAMNDAAESVGV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: ID3B_XENLA
Sequence: MKAISPVRSMSSCYQAVCCLSEQSLSIARGSSLKGAGIDETMGLLYDMNGCYSKLKELVPGIPQGSKLSQVEILQHVIDYIFDLQIVLGEDQQQNSILNLQKSDFSELATQGDARVCH
What is the function of this protein?
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity.  Influences cell fate decisions in the embryo by sequestering and blocking the activity of the bHLH transcription factors that control these decisions.  Inhibits the binding of myogenic bHLH-containing complexes to E-box DNA, thereby preventing activation of muscle-specific target genes.  Also inhibits the activity of neurogenic factor neurod1/neuroD.  Plays a role in cell cycle progression and survival of neural crest progenitors; binding to either hes4-B/hairy2b or stat3 blocks the formation of transcription factor complexes and the repressor function of hes4-B/hairy2B, to allow neural crest progenitors to differentiate.  May play a role in the regulation of the circadian rhythm (By similarity).
What are the official names of this protein?
DNA-binding protein inhibitor ID-3-B, Inhibitor of DNA binding 3-B, XIdIIa, Inhibitor of differentiation 3-B.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECX_CLOAB
Sequence: MEENTITKIEAQKKKKDRVNVYIDNEYSFSCNTELIYIHGLKKGKVVDLDYLQDIIEEDNYLYAKSRALSFIEKTFKTEKEIRVKLREKEFNEKIIERVIEFLRKYDFVDDSRYAELYIKERINKQGKVKIKYGLIKKGINDSIIDEKLSKYSANNENYIEAMREVALKKFNNIAKRETDKLKIKRKLSSYLLGRGYSWSEIGEVLKEIFSENN
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO4_SHESM
Sequence: MRKIIHIDMDCYFAAVEMRDFPEYRGKPLAVGGSRVQRGVISTCNYEARKFGVRSAMATGYALKLCPNLILVPGRMQVYKEVSQQIRAIFSRYTELIEPLSLDEAYLDVSDCKLFKGSATLIAEAIRRDILAETGLTASAGVAPIKFLAKVASDLNKPNGQCVIPPDEVPEFVKSLSLRKIPGVGKVTAEKLSSLGLNTCADVQAYPKQELIARFGKFGAVLVERAHGIDERGISVSRERKSVGVETTLAQDIYTLEQCQQVMPGLIQELSSRLVRSAKGRQIHKQVVKLKFNDFKQTTIEHRSDEVSVVMFYELLSQAMARQEGRGIRLLGVSVGLAETKDTLSPLMVRETKQLDFVF
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.