PharMolix/UniProtQA huggingface dataset:
Protein: XGPT_PECAS
Sequence: MSEKYVVTWDMLQIHARKLAQRLLPAEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQREMKVIKRAEGDGEGFIVVDDLVDTGGTAKAIRDMYPKAHFVTIFAKPAGQPLVDDYVIDIPQDTWIEQPWDMCVVFVPPLSGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GLYA_STAMF
Sequence: MVIDITKKYPELKEIYELTVNHTIWRKKECINLIASENVMSPLAMLLYLNDMMHRYAEGKPFKRFYQGLKFVDELEVKAQRIIGELLETDYVELRPISGTIANATVFKAFAEHGDKAVVVPVQAGAHVSHTRYGTLGGLGIEQVEMPFNIEEWNIDVDGAKKVIEKVKPKIVILGGSLYIFPHPVKEIAEAAHSVGAKLMYDVAHVLGLITGKVWENPLKQGADILTSSTHKTFPGPQGGLIATVTKDDYKKVSKIVFPVFVSNHHLHRLAALAVTGLEMKYFGRQYAEQIVKNAKAFAEALAENGFKVIGENKGYTESHQVIIDVREHGGGAKNAKLLEEANIIVNKNMLPWDKPEDIKNPSGIRLGVQEVTRWGMKEEDMKTIAEFMRLVVIDKRDPKEIRNKVIEFRKNFLEIHYGFKISGEEETKLLKIMLHGEV
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASAB_ASPFN
Sequence: MRFRQQVETCLNYWPAEGPVQRELILGTVGAYRRPIDSRPVLIQDVRGQEGTFTLDIHGFQFIKHISQHVASFDEASVLKDNMTALEAEHLLKTRWAIVNIWRPLKPVPRDPLAVSDARSFHDKDLLEIYGRVPGRQAKKDYDAATKGSGFGMLYGKYSPGQQWFYMSDMKPDEALLIKCYDSKDDGRTARRTPHTAFVDPRTRDVKVARESLELRCLVFFEDQPLA
What is the function of this protein?
Hydroxylase/desaturase; part of the gene cluster that mediates the biosynthesis of aspergillic acid, a hydroxamic acid-containing pyrazinone with aliphatic side chains that originates from leucine (Leu) and isoleucine (Ile) (PubMed:29674152).  Aspergillic acid has antibiotic properties and was shown to be lethal to mice (PubMed:29674152).  The first step in the pathway is the production of deoxyaspergillic acid via a condensation between the Ile amine and the Leu carboxylic acid, followed by a reductive release from the protein forming the dipeptide aldehyde NH(2)-Leu-Ile-CHO, which could undergo an intermolecular cyclization resulting in a dihydropyrazinone (PubMed:29674152).  As the NRPS asaC lacks a condensation domain, it is improbable that it is responsible for condensation of Leu and Ile (PubMed:29674152).  One possibility is that asaC acts on a previously condensed dipeptide and functions as a Leu-Ile reductase to yield deoxyaspergillic acid (PubMed:29674152).  After asaC forms deoxyaspergillic acid, the cytochrome P450 asaD oxidizes the pyrazinone to the hydroxamic acid-containing bioactive metabolite aspergillic acid (PubMed:29674152).  The hydroxylase/desaturase asaB can then convert aspergillic acid to hydroxyaspergillic acid (PubMed:29674152).  Both aspergillic acid and hydroxyaspergillic acid can form complexes with iron producing ferriaspergillin analogs (PubMed:29674152).
What are the official names of this protein?
Hydroxylase/desaturase asaB, Aspergillic acid biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the asaB hydroxylase/desaturase family.
Protein: DPYD_DANRE
Sequence: MATMLSKELQDIESILALNPRVKSHANVHSTASKKNEKKHWKRNPERSCDSCVNLENNFDDIKHTTLSERGALREALRCLKCADAPCQKSCPTNLDIKSFITSISNKNYYGAAKAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQIRNPELPTADNMPKSFHTRIALIGCGPASISCASFLARLGYDNITIFEKQKYIGGLSTSEIPQFRLPYEVVQFEIDLMKDLGVKVVLEKGLGQNGLTLTSLKEEGYQVVYIGIGLPQANRDKIFEGLTTEQGFYTSKDFLPLVAKASKIGMCNCRSQLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNIRAVPEEMEAAKEEKCEFLPFLSPHEVIKKNGRVSGLRFCRTEQQDDGTWIVDEEQIVHLKADFIISAFGSMLNDPAVTKALDPIKLNRWGTPEVNSETMQTTEPWVFAGGDIAGFANTTVESVNDGKQASWHIHKYIQSLHGNTISATPRLPLFHCSIDTVDISVEMCGIKFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFGLDKDLVTNVSPRIVRGTTSGHIFGPGQGSFLNIELISEKTAAYWCKSVAELKADFPKNIIIASIMCSYNQADWTELAKMAQESQADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRKATSIPFFAKLTPNVTNIVDIATAAYEGGADGVTATNTVSGLMALKADATPWPGIGRGARTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTVIEDYCLGLKALLYLKSIEELHDWDGQSPPTIRHQKGKPVPHVSELIGKSLPSFGPYLQTKTQALAKYKKDASGDVIMDTGAARVNIPKKPIPNVKDVIARALKHIGAYQELDNTEQVQALVDPEMCINCGKCYMTCNDSGYQAIKFDPETHLPVITDSCTGCTLCLSVCPIIDCIKMVSRTTPYEPKRGLPVNPVC
What is the function of this protein?
Involved in pyrimidine base degradation.  Catalyzes the reduction of uracil and thymine.  Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
What are the official names of this protein?
Dihydropyrimidine dehydrogenase [NADP(+)], DHPDHase, DPD, Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the dihydropyrimidine dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HAT2_NEUCR
Sequence: MARDEIVDDVDVNMEEDDAEAEQRLINEEYKIWKKNSPFLYDMMLSTALEWPTLTTQWFPDVKNPKDKSHTVHRLLLGTHTAEGKPNYLQIAEVEIPKMVELNPRDYDEERGEIGGYGSKASSGEPLCIRFKITQKIDHPGEVNKARYQPQNPDIIATLAVDGRVLIFDRTKHSITPSGTPSPQLELIGHKEEGFGLNWNPHEEGCLVTGSEDKTVLLWDLKTYEGTSKQLKYSRKYTHHSHIVNDVQHHPLVKSWIGTVSDDLTLQIIDVRRPETDKAAIVARNGHSDAINALAFNPRVETIIATASADKTIGIWDMRNMKSKVHTLEGHQDAVTSLEWHPTESAILGSGSYDRRLLFWDISRVGDEQTQDDAEDGPPELLFMHGGHTNHLADFSWNRNDPWLVCSAAEDNLLQIWKVANSIVSKEPADMSTPELDDPKPKQSSH
What is the function of this protein?
Regulatory subunit of the histone acetylase B (HAT-B) complex.  The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing.
What are the official names of this protein?
Histone acetyltransferase type B subunit 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LEUD1_PYRAB
Sequence: MRVRGRAWKYGDNIDTDVIIPARYLNTSDPKELAKHVLEDLDPEFRSKMKPGDIIVAGENFGCGSSREHAPLAIKAAGVSCVIAKSFARIFYRNAINIGLPILEAPQAVDRIETGDELEVDFSSGEIRNLTKGEVYRANPFPDFIMEIIKAGGLVEWAKRRLKG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit 1, Alpha-IPM isomerase 1, IPMI 1, Isopropylmalate isomerase 1.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: RUVC_NEIMF
Sequence: MSATVRILGIDPGSRVTGFGIIDVRGRDHFYVASGCIKTPPDAPLADRIAVIVRHIGEVVAVYKPQQAAVEQVFVNVNPASTLMLGQARGAALAALVSHKLPVSEYTALQVKQAVVGKGKAAKEQVQHMVVQMLGLSGTPQADAADGLAVALTHALRNHGLAAKLNPSGMQVKRGRFQ
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: GUC1A_HUMAN
Sequence: MGNVMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIQAIRAINPCSDTTMTAEEFTDTVFSKIDVNGDGELSLEEFIEGVQKDQMLLDTLTRSLDLTRIVRRLQNGEQDEEGADEAAEAAG
What is the function of this protein?
Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:19459154, PubMed:30622141, PubMed:18706439, PubMed:30184081).  This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).  May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity).
What are the official names of this protein?
Guanylyl cyclase-activating protein 1, GCAP 1, Guanylate cyclase activator 1A.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=Present at higher levels in cone than in rod outer segments (PubMed:9620085). Subcellular location is not affected by light or dark conditions.
Protein: NFUA_ALTMD
Sequence: MITISEEAQAHFVKLLSKQESGTNIRVFVVNPGTSSAECGVSYCPPDAVEETDTRLTFNGFDAVVDEESAPYLDEAEIDYVTDQMGSQLTLKAPNAKARKVSDDAPLIERINYMIESEINPQLANHGGQVVLTELTDDGYAVLQFGGGCNGCSMVDVTLKDGIEKQMLEQFAGELNGVRDATEHQAGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: Y781_METJA
Sequence: MIIKNQLIFVNFYVILIIWWFVMGILDKIQKKSEKIEKEKKSETVIPSDTKLKPIEPHPTINKKATVGNDETILDTYSIKIDEIEMEVVIKREEGYIYYLVPEIDKINMSLSKLTKDHLNHIKSQISDLGLIEYDQIREYLTNFSMRYNLAIPYIDSLAKFFYLVIGRLGLLEVPLNDDRLEEVMVNGYNVPVFVFHRKHQMCETNIVLDRNEVDRIIESIANLVNRPIDSRVPMLDAFLPDGSRVNATTADITMNGATLTIRKFSKNPLTVIDLINFGTLDIDTAAFLWQAVEGYFGAKPANTLIAGGTGSGKTTLLNVLSLFSMYNERIITIEDTPELQIPHKHVIKMVTRPARPGMPEYEVTMDDLIKNALRMRPDRIFVGEVRGKEAHSLLVAMNTGHDGALAYDEPIYLSDGNIINIGEFVDKFFKKYKNSIKKEDNGFGWIDIGNENIYIKSFNKLSLIIEDKRILRVWRKKYSGKLIKITTKNRREITLTHDHPVYISKTGEVLEINAEMVKVGDYIYIPKNNTINLDEVIKVETVDYNGHIYDLTVEDNHTYIAGKNEGFAVSNCSGTLHANSADEAILRLTSPPMNVPKIMLTALNFIINQQRIRRAGKTIRRILGIVEIVKGGGEGHEFAKTTLYEYNGLKDSLERRGICMWEEEVCEIAGITKEELLRDRENRKKVLSYLYKNNIRKLENVSDYIMRYQVDPEKLLRSIR
What are the official names of this protein?
Uncharacterized protein MJ0781.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AMY_PRIMG
Sequence: MKGKKWTALALTLPLAASLSTGVDAETVHKGKAPTADKNGVFYEVYVNSFYDANKDGHGDLKGLTQKLDYLNDGNSHTKNDLQVNGIWMMPVNPSPSYHKYDVTDYYNIDPQYGNLQDFRKLMKEADKRDVKVIMDLVVNHTSSEHPWFQAALKDKNSKYRDYYIWADKNTDLNEKGSWGQQVWHKAPNGEYFYGTFWEGMPDLNYDNPEVRKEMINVGKFWLKQGVDGFRLDAALHIFKGQTPEGAKKNILWWNEFRDAMKKENPNVYLTGEVWDQPEVVAPYYQSLDSLFNFDLAGKIVSSVKAGNDQGIATAAAATDELFKSYNPNKIDGIFLTNHDQNRVMSELSGDVNKAKSAASILLTLPGNPYIYYGEEIGMTGEKPDELIREPFRWYEGNGIGQTSWETPVYNKGGNGVSVEAQTKQKDSLLNHYREMIRVRQQHEELVKGTLQSISVDSKEVVAYSRTYKGKSISVYHNISNQPVKVSVAAKGNLIFASEKGAKKVKNQLVIPANRTVLIK
What are the official names of this protein?
Alpha-amylase, 1,4-alpha-D-glucan glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: LFTR_BURA4
Sequence: MVPWLGPDDPFPPVERALGPATGAPGLLAASADLLPSRLIEAYLRGIFPWYSDGQPVLWWSPDPRMILAPAEFKVSPSLRKTLRRVLREPAWEVRVDHDFAGVMRACAQAPRRGQRGTWITAEIIDAYTSLYRSGNAHSIETWHDGRRIGGLYGVAFGRMFFGESMYADATDASKIALATLVAHLREQGLEMIDCQQNTSHLASLGGREIARKAFVAHVRRAVAEPPIPWQFDKRVLAALTGPAEPAAPSGIER
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XEN3_XENLA
Sequence: LKCVNLQANGVKMTQECAKEDTKCLTLRSLKKTLKFCASDRICKTMKIASLPGEQITCCEGNMCNA
What is the function of this protein?
Lacks alpha-neurotoxic activity, has apparently no antibacterial activity, nor anti-coagulant potency.
What are the official names of this protein?
Xenoxin-3.
What are the subcellular locations of this protein?
Secreted.
Protein: TSDA_STUS1
Sequence: MNTQLLVTLLAMSIGGVALAAEIKMDDQSQLTQKAGKGAGESYFQPPQEKDLPANAYGELVQQGRAIFVDTQKYAAEYVGNGMNCTNCHLEQGRKANSAPLWGAYPMYPAYRKKNDKVNSYAERVQGCFQFSMNGTPPAADSHVINALTAYSYWLSTGAPTGQELPGRAYPEVPQPQGGFDIAKGKQIYAEQCAVCHGDDGQGQKAGGGYVFPPLWGKDSFNWGAGMHRINTAAAFIKESMPLGKGGSLSDADAWHVAAYMNSHERPQDPRLIEGSVEKTRLKYHANDGVNLYGQQVDGALLGQGVK
What is the function of this protein?
Catalyzes the oxidation of 2 molecules of thiosulfate to tetrathionate, using TsdB as an electron acceptor.
What are the official names of this protein?
Thiosulfate dehydrogenase, Tetrathionate synthase.
Protein: CCNB1_CAEEL
Sequence: MLRATNNRRTSNNVEKDSLQMAKHGNGPLKPVNAQGLQTKREAREILALKPSNPAPVETAQKSQRINLQDAETKCLAMADDIYKYLVHHEKKYLLEECFMEGGEPTPKMRRILVDWLVQVHVRFHLTPETLHLTVFILDRMLQKKVTSKADLQLLGISAMFVASKFEEVYLPDIHDYEFITENTYSKKQILAMEQTILNSLNFDLSCPSSLVFLRCLSRILSENDASPIDNQAFCYTYNISKCLGELALLDSVMASTPRSHIASASMIIALEVHPVDGIEAENAVSVICKQLGASKKVIEDAVALLAEVSYKNFKQGKLVAIKNKYQSSKLAQVSNLMTDDVLEKINRMGQNAKVDASEME
What is the function of this protein?
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
What are the official names of this protein?
G2/mitotic-specific cyclin-B1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: USPA_PASMU
Sequence: MYKHVLVAVDLSDESQFLLEKAAGVARRNEAKLSIIHVDVNFSDLYTGLIDVNMASMQDRISTETQQSLVQLAENSSYPVAEKLSGSGDLGQVLADAIEKYDVDLLVTGHHQDFWSKLMSSTRQVMNNIAVDMLVVPLRDE
What is the function of this protein?
Required for resistance to DNA-damaging agents.
What are the official names of this protein?
Universal stress protein A homolog.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_LEPBL
Sequence: MIESKNQSFFPNRFDCVVVGAGHAGSEAAYIASKGGAKTLLITMNLDTIGQMSCNPAIGGIAKGHMVREVDALGGIMGKVIDNTGIQFKMLNTSKGPSVWAPRAQAEKKEYQLKVKHTLEAEKNLSMRQDTVEELLIENDQVIGVKTGRGFEIYTNHVILTTGTFLSSLVHIGTYQNENGRMCEPTVKGLSKSLAKYNLKLGRLKTGTPPRIHKNSVDLSVLAIQDGDANPSPFSFSTEKITRRQIPCYITYTNVETHKLIHENLSLSPMYSGQIQSTGPRYCPSIEDKVVRFADRERHQVFLEPEGYETTEIYLNGVSTSLPEEVQWKLVRSLKGLENAEIVRPGYAIEYDYVDPTELKPTLETKKIKGLYHAGQINGTTGYEEAAAQGLVAAYSVLHSLKNLDPLLFKRSESYIGVLIDDLVYKGVEDPYRMFTSRAEHRLLLRQDNADQRLMKYGYELGLVDQESYDRMKDKYERVNSVREKIYQIPLKPSDEFQNLLDQKGITNYKFGMKLDSFLKRPEIKIEDVEFMLPEVSSWSESEKNILEMEIKYEGYIKRELETIQWKNKYLDLAIPEDINYESIAGLKKEAIQKLKTHKPMTLEKAGQISGVDPSDVDLLLYHIKGKRKQEAEAS
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_CHLPM
Sequence: MKKEILEVFDNTYPDRNYTIEIVNPEFTSVCPKTGLPDFGTITVHYVPDRTCVELKSLKYYFLEFRNAGIFYENITNRILDDLVAAMQPRSITVTTKWKARGGITETVTASHTAQG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOC2L_CAEEL
Sequence: MKLLKKPAGLKKRKVISKRIKIEKKPSSEDEGSSDEEVPKLDGEGSLDGSEDEDDGTVTVEKGGVKKHKLDLEKLKQSDPEFFKFLQQEDADLLNMEDDGDDDEDDDEDDEDEEEEESDDDEDDEEDDDKTKIKKIRKPKIKSDNSGRLIVDSNVYSYLQQVLVLDDETSTPTNPSDVRMAVDVFVACVARVGADIEAPKYVINEQSIFEAVVRMCFQAMPDILKRLLKAKPEGDKVLFSKTAIKKYQTYVRTYLHAMIVFLNEVQTTEVLIATIKAMTRLVDLYAHFSRMSKLLIKAVVRIWSRKTLECRLPAFVCMNLLVKNYPQHFVPLYKTAYVAFVANSKIVTNETWPLLQFMHRTFAELTILNPEQAYKYAFVYIRQTAVHLRNAMISKGRKDLIFSIYNWQMMQCMYMWVRVIAKAHSVNGAEQIGELVYPLIQVIVGIFKLCNAPTFLPLRLHCCQLLIQLQASCTNYIPILQVSCDCLEELARELKSKPKPVKGAVKLPDIECTLKCSSQFSDLPQWRKVISEHVFRTMMQSAHLLASQAAFPDVVLPINHRISAILETMKNGDHAHLFRGFQTKLKEHSRFVLDVLARKSVDINDEMQVRAVRFDLNNPDSPIKTFYRQWEKVWKMKERSAVENSKKDDKKKKKEEEAAAAKKRKPNETVEDEDDVKPEVSKAKRKRIKIGAAAKKADASVPDQFADMSMWSDED
What is the function of this protein?
Required for normal somatic gonad development and for regulation of germline development and proliferation.
What are the official names of this protein?
Nucleolar complex protein 2 homolog, Protein NOC2 homolog, Proximal proliferation in germline protein 2.
What is the protein family that this protein belongs to?
Belongs to the NOC2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECF_SALHS
Sequence: MSLTRLLIKDFRNIENADLALSPGFNFLVGANGSGKTSVLEAIYTLGHGRAFRSLQPGRVIRHEQEAFVLHGRLQSEERETSIGLTKDKQGDSKVRIDGTDGHKIAELAHLMPMQLITPEGFTLLNGGPKYRRAFLDWGCFHNEAGFFTAWSNLKRLLKQRNAALRQVSRYEQLRPWDKELIPLAEQISTWRAEYSSAIAQDMADTCQQFLPEFSLTFSFQRGWEKETDYADVLERSFERDRMLTYTAHGPHKADFRIRADGAPVEDTLSRGQLKLLMCALRLAQGEFLTRESGRRCLYLIDDFASELDDARRGLLASRLKATQSQVFVSAISAEHVIDMSDENSKMFTVEKGKITD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKHM2_MOUSE
Sequence: MEPREVKDRILENISLSVKKLQSYFAACEDETPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAIRQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLQKYYVRNALVCSHDHLTLFLTLVSGLEFIRFDLDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDGDLTDTISGPRSTASDLTSSKTSTKSPTQRHNPFNEEQAETASSDTTPVHTTSQEKEEAQAPDQPDACTELEVIRVTKKKKIGKKKKTKLDEDASPLHPTSSQQKCGQQGEGDGLVGTPGLARDPSDTVLASPQEQGEGLSSTAGSSELSELSQMGLLIPEMKDTSMECLGQPLSKVIDKLHGQLDPSTWCSHADPPEQSFRAGSPGEAPEKPPFCDFSEGLPAPMDFYRFTVESPSTVAPGGGHHDPPGPSQPLHVPGSPAAALQEEEEGGRGEGQTSQPVEDRQGEEIQEPEPQEPDSQLPLVSQEPLVSQEPVPEPVSQPEPGTHEALCKLKRDQPSPCLSSAEDSGVEEGQGSPSEMTHPSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAELFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASAVTVHFYGLVHWEDPMEEALGPVPCQCSPAEGTITKEGMLHYKASTSYLGKEHWKACFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRSNTTDRPHAFQVILADRPCLELSADSEAEMADWMQHLCQAVSKGVIPQGIAPSPCIPCCLVITEDRLFTCHEDCQTSFFRSLGTARLADITAISTELGKEYCVLEFSQDSPQLLQPWVIYLSCTSELDRFLTALSSGWKAIYQVDLPHKAIHEASIKQKFEDALSLIHSAWQRSDSLCRGRASRDPWC
What is the function of this protein?
Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B.  Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends.  Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility.  Critical factor involved in NK cell-mediated cytotoxicity.  Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells.  Required for maintenance of the Golgi apparatus organization.  May play a role in membrane tubulation.
What are the official names of this protein?
Pleckstrin homology domain-containing family M member 2, PH domain-containing family M member 2.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y1150_METJA
Sequence: MVLMKDEVEVIGFDDAPFNKADKVCILIGTYMRGNRIIDGIYFRKFKKDGMDVTEKIIDIVKEKHYKKIKVIFLAGITFGGFNIADLWEINKETEKPVIVVIDKYPNKEKIFLALKKYFDDADERIKLINSFPEPEKMENIYVQYVGADKEFVKNVIKKTKLKSKIPECLRISHLIGRGFLGLR
What are the official names of this protein?
UPF0215 protein MJ1150.
What is the protein family that this protein belongs to?
Belongs to the UPF0215 family.
Protein: PSBK_PELHO
Sequence: MINIFSFICIYLHSALYSSSFFFGKLPEAYAFLNPIVDVMPVIPLFFFLLAFVWQAAVSFR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ACPS_CHLTA
Sequence: MFGVGIDIIEIDRIRKSYQTYGDRFLKKIFTEGERVYCFSKSNPYASLAARFAAKEAVAKALGTGIGKLLKWKEIEMCRDSRQPQVVVPEALLCSLGVKRVLLSVSHSREYATAVAIAE
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERI1_MOUSE
Sequence: MEDERGRERGGDAAQQKTPRPECEESRPLSVEKKQRCRLDGKETDGSKFISSNGSDFSDPVYKEIAMTNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNYYKKQKLMLKESSAGDSYYDYICIIDFEATCEEGNPAEFLHEIIEFPVVLLNTHTLEIEDTFQQYVRPEVNAQLSEFCIGLTGITQDQVDRADAFPQVLKKVIEWMKSKELGTKYKYCILTDGSWDMSKFLSIQCRLSRLKHPAFAKKWINIRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPHSGLDDSKNIARIAVRMLQDGCELRINEKILGGQLMSVSSSLPVEGAPAPQMPHSRK
What is the function of this protein?
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication.  A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates.  Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi).  Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure.  Able to bind other mRNAs (By similarity).  Required for 5. 8S rRNA 3'-end processing.  Also binds to 5. 8s ribosomal RNA (PubMed:18438418).  Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.  In vitro, does not have sequence specificity.  In vitro, has weak DNA exonuclease activity.  In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (By similarity).
What are the official names of this protein?
3'-5' exoribonuclease 1, 3'-5' exonuclease ERI1, Eri-1 homolog, Histone mRNA 3'-exonuclease 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus.