PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_STRPZ
Sequence: MKKRIKELTDLLNRYRYDYYTKDAPSVSDSDYDKLYRELVTLEQSYPEYVLQDSPTQQVGGTILKGFEKYRHQYPLFSLQDAFSREELDAFDKRVKAEFPNATYLAELKIDGLSISLSYENGFLQVGATRGDGNIGENITENIKKIKDIPHQLSEPLTITVRGEAYMSRQSFKAINEARQENGETEFANPRNAAAGTLRQLDTAVVAKRELATFLYQEASPTARNQQNEVLAELADLGFSVNPYYQLTSSMDEIWDFIKTIEAKRDQLAYDIDGVVIKVNSLAMQEELGFTVKAPRWAIAYKFPAEEKEAEILSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIAEKDIRIGDTVIVYKAGDIIPAVLNVVMSKRNQQEVMLIPKLCPSCGSELVHFEDEVALRCINPLCPSLIQRSLEHFASRDAMNITGLGPAIVEKLFLAGFVHDVADIYQLTKENFMQLDGIKEKSADKLLAAIEASKSNSAEKLLFGLGIRHIGSKVSRLILEVYGDISALLTAKEEEIARIDGLGSTIAQSLTQYFEQKTAAILVDELKTAGVNMHYSGQKVNSDAALFGLTVVLTGKLNQLNRNEAKDKLEALGAKVTGSVSKKTDLVIAGSDAGSKLEKAKSLGIRIEDEDWLRQL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: IF1C_PHAAO
Sequence: MKEQKLIHEGLITESLPNGMFRVRLDNEDLILGYISGRIRRSFIRILPGDRVKIEMSRYDSTRGRIIYRLRKKDSND
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y1306_BRUC2
Sequence: MAKKKDTPGDGEFPGFSDTLQRTPKLEKPHYAGHRDRLKQRFRDAPDALADYELLELLLFRAIRRADTKPIAKALLNRFGSIAEVLAAPENLIAEIPGAGPTVALELKLVEAIAKRSARSTVMEREVLGSWDKVINYCTAAMAFETREQFRILFLDKKNKLIADEVQQTGTVDHTPVYPREVVKRALELSATAIILVHNHPSGDPTPSRADIDMTKQLVNAAKALNITVHDHVIIGKHGHASLRSLRLI
What are the official names of this protein?
UPF0758 protein BCAN_A1306.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: VL2_HPV54
Sequence: MAKARAPRRKRASATQLYQTCKASGTCPSDVIPKVEGTTIADQILRWGSMGVFFGGLGIGTGSGTGGRTGYIPLGRPSTTLEPGPPVRPAGAVETVAPSDPSIVSLVEESSVVDVGAPTPTIPSQGGFEIATSSDATPAILDVTSTTTPIRVSITSHDNPIYTEPSLLDPPPPVQMDGRVLVSTSTLQSSTAENIPMDTFIIMQDHIGTTTSTPIPRPPARPRLGLYSRALQQVPVQDPAFLQQPSSLITYDNPVYEGNPDVTLHFEQPTIHNAPDPAFMDIFALHRPALTTRRGVVRYSRVGDRATLHTRSGLQLKPRVHFFQDLSPIAHVPEEIELHPLISANNTSINNGLYSDIYDVYADTDFADTGGFSSSTVSHSSVQTALQTTSIPSQYGNTTVPLTASSPYTPIPTSFRPSSGHTPFVPARPIFPQTPIAVNGGDFYLHPSYTYVRKRRKRFPYFLADGYVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: YVAC_VACCC
Sequence: MALMAITKNVKYFSMLGIWFFTLIDIWFLAKMIDIFLSEDSKILLVAVSIKMKLVSISNFILELIGVAKCTLYVISPLMRSICVSISDTRSVNSFTLLIITVSPSLDNANVPSKSQMERFNCSSFRIK
What are the official names of this protein?
Uncharacterized 14.4 kDa protein.
Protein: PAAF1_CHICK
Sequence: MAATLRIQSDWSQALRRDEGEAWLSCRSPGKPTLYGSLTRRGLSTEGVPDIAASEGFVVGEVTKKSILISCPHENVSTKFLAPYTTFSRIHQKSITCLDISSGGGLGVSTSTDGTMKIWQAANGEIRRLLEGHVYDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVLSCSRDGTARLWDCGKSSCLAVIADCGSPINGIAVGTADDSVNLGTPEKAPSEREIGTEGKILLLAREDKKLQGVGLQSRQPVFLFDGSDAFNCCTFLSSTYFLAGTQDGNIYQLDVRNTNAPIQIIHRSGAPVLSLLPYRDGFIASQGDGTCFIVQQDLDYVIDLTEADCDPVYKVAPWEKQIYTCCRDGVVRRYQLGDL
What is the function of this protein?
Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core.
What are the official names of this protein?
Proteasomal ATPase-associated factor 1, WD repeat-containing protein 71.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PAAF1/RPN14 family.
Protein: TTC1_HUMAN
Sequence: MGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR
What are the official names of this protein?
Tetratricopeptide repeat protein 1, TPR repeat protein 1.
Protein: CD5_HUMAN
Sequence: MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGPTGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPDNSSDSDYDLHGAQRL
What is the function of this protein?
May act as a receptor in regulating T-cell proliferation.
What are the official names of this protein?
T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NEF_HV197
Sequence: MGGKWSKSSIVGWSTVRERMRKTPPAADGVGAVSQDLDKHGAVTSSNTAFNNPDCAWLEAQEDEDVGFPVRPQVPLRPMTFKGAFDLGFFLKEKGGLDGLIYSKRRQEILDLWVYHTQGFFPDWQNYTPGPGIRYPLTFGWCYKLVPVDPREVEEATEGENNCLLHPVNQHGMEDEHREVLKWKFDSSLARKHVAREMHPEYYKDC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: YR158_MIMIV
Sequence: MDHQSVVYNVYINQLNLYDCDYQKINMIEKFGPTIIVDQHVIVDTMSSIKTDSYKIDALKILLPMFMNPSLDVLLCVIDVISSDSYKIDAIKTLLQYCLEKPVDINIIEKYICCLGGDSYRLDAIIKLHTRLSTMDYSTVEQIIVLVRSDSYRLDVLKKISHKFEKQDAIKTINLIRSDSYKLDYILFVVDTKFLSLDESISLIDLLESNSYKSTYAEKIINTNSTITFNQIVQLTKDLPDTYRLGIADSFIKQLETFDTDNTDIFCQNLGKLTNYASYNQTVERLKIDKTISDKYKPCELTNTMSTSIFNLPVNSHNPLSINFIGNISPNAGTMVYKSIQENNGITTVTIKYSNGSSNIIMIDNNEKKN
What are the official names of this protein?
Uncharacterized protein R158.
Protein: SLYX_THISH
Sequence: MSDALEARVMELEIRLAHQEDLLQSLNQTMIEQQQRIDSLQLQMEGLRQRLAAVIENPLMDPNQEPPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: NTPPB_BORBR
Sequence: MPAIPPKLILASSSRYRRELLSRLRLPFTAISPDVDETPQPGEAPADLALRLSVAKAMAVAATHPGSVVIGSDQVATVDGDPIGKPGGFERAREQLRRLSGRAVEFHSAMAVTDGVHTETADIVTLCRFRTLTDAAIDAYLRAEEPYDTAGSAKAESLGIALMDSIRSDDPTAIIGLPLIALTRMLGRFGLDPLTGHPA
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_SHEPA
Sequence: MAKSSMKAREAKRAQLVAKFAEKRAALKAIISSPTTSDDDRWDAVLKLQALPRDSSAARQRNRCSQTGRPHGFLRKFGLSRIKLREATMRGEVPGLRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: DEF_GLOMM
Sequence: MKFYLVLAFLTLCAVAVTALPAGDETRIDLETLEEDLRLVDGAQVTGELKRDKRVTCNIGEWVCVAHCNSKSKKSGYCSRGVCYCTN
What is the function of this protein?
Antibacterial peptide mostly active against Gram-positive and Gram negative bacteria.
What are the official names of this protein?
Defensin-A, DefA, GmDefA.
What is the protein family that this protein belongs to?
Belongs to the invertebrate defensin family. Type 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SMIM5_HUMAN
Sequence: MAATDFVQEMRAVGERLLLKLQRLPQAEPVEIVAFSVIILFTATVLLLLLIACSCCCTHCCCPERRGRKVQVQPTPP
What are the official names of this protein?
Small integral membrane protein 5.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YJJB_SALDC
Sequence: MGIIDFLLALMQDMILSAIPAVGFAMVFNVPHRALPWCALLGALGHGSRMLMMSAGFNIEWSTFMASLLVGSIGIQWSRWYLAHPKVFTVAAVIPMFPGISAYTAMISAVKISHLGYSEPMMITLLTNFLKASSIVGALSIGLSVPGLWLYRKRPRV
What is the function of this protein?
Involved in succinate export with YjjP.  Both proteins are required for export.
What are the official names of this protein?
Probable succinate transporter subunit YjjB.
What is the protein family that this protein belongs to?
Belongs to the ThrE exporter (TC 2.A.79) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACSA1_PSEPK
Sequence: MSAAPLYPVRPEVAATTLTDEATYKAMYQQSVINPDGFWREQAQRIDWIKPFTKVKQTSFDDHHVDIKWFADGTLNVSSNCLDRHLEERGDQLAIIWEGDDPSEHRNITYRELHEQVCKFANALRGQDVHRGDVVTIYMPMIPEAVVAMLACARIGAIHSVVFGGFSPEALAGRIIDCKSKVVITADEGVRGGRRTPLKANVDLALTNPETSSVQKIIVCKRTGGDIAWHQHRDIWYEDLMKVASSHCAPKEMGAEEALFILYTSGSTGKPKGVLHTTGGYLVYAALTHERVFDYRPGEVYWCTADVGWVTGHSYIVYGPLANGATTLLFEGVPNYPDITRVSKIVDKHKVNILYTAPTAIRAMMAEGQAAVEGADGSSLRLLGSVGEPINPEAWNWYYKTVGKERCPIVDTWWQTETGGILISPLPGATGLKPGSATRPFFGVVPALVDNLGNLIDGAAEGNLVILDSWPGQSRSLYGDHDRFVDTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESAMVAHSKVAEAAVVGVPHDIKGQGIYVYVTLNAGIEASEQLRLELKNWVRKEIGPIASPDVIQWAPGLPKTRSGKIMRRILRKIATGEYDALGDISTLADPGVVQHLIDTHKAMNLASA
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase 1, AcCoA synthetase 1, Acs 1, Acetate--CoA ligase 1, Acyl-activating enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: CYMC7_MELCT
Sequence: GIPICGETCTIGTCNTPGCTCSWPVCTRD
What is the function of this protein?
Probably participates in a plant defense mechanism (Potential).  Binds to and induces leakage in phospholipd membranes, particularly ones containing 1-palmitoyl-2-oleophosphatidylethanolamine (POPE) (By similarity).
What are the official names of this protein?
Cyclotide mech-7.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: VLF1_NPVAC
Sequence: MNGFNVRNENNFNSWKIKIQSAPRFESVFDLATDRQRCTPDEVKNNSLWSKYMFPKPFAPTTLKSYKSRFIKIVYCSVDDVHLEDMSYSLDKEFDSIENQTLLIDPQELCRRMLELRSVTKETLQLTINFYTNMMNLPEYKIPRMVMLPRDKELKNIREKEKNLMLKNVIDTILNFINDKIKMLNSDYVHDRGLIRGAIVFCIMLGTGMRINEARQLSVDDLNVLIKRGKLHSDTINLKRKRSRNNTLNNIKMKPLELAREIYSRNPTILQISKNTSTPFKDFRRLLEESGVEMERPRSNMIRHYLSSNLYNSGVPLQKVAKLMNHESSASTKHYLNKYNIGLDETSSEEENNNDDDDAQHNRNSSGSSGESLLYYRNE
What is the function of this protein?
Plays a role in nucleocapsid assembly and serves an essential function during the final stages of the DNA packaging process.  Participates in the processing of branched DNA molecules at the late stages of viral genome replication.
What are the official names of this protein?
Very late expression factor 1.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: GCSH_SINFN
Sequence: MLKFTEEHEWLKVEGGVATVGITEHAAGQLGDLVFVELPEAGATFSKGDSAATVESVKAASDVYCPLDGEIVEINQAIVDDPSLVNSDPQGAAWFFKLKLADPRSADNLLDEAAYKELVG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: KAO1_HORVU
Sequence: MGEGAWWAVAAVVAALAVVALDAAVRAAHAWYWTASLGAGRRGRLPPGDMGWPLVGGMWAFLRAFKSGRPDSFIDSFARRFGRAGLYRAFMFSSPTIMATTPEACKQVLMDDDAFVTGWPKATVALIGPKSFVNMGYDEHRRLRKLTAAPINGFDALTSYLGFIDDTVVTTLRGWSERGGDGHFEFLTELRRMTFRIIVQIFMGGADERTAAELERTYTELNYGMRAMAIDLPGFAYHKAIRARRRLVAALQRVLDERRARGGKTAAGAAAPVDMMDRLIAVEDEGGRRLQDDEIIDVLVMYLNAGHESSGHITMWATVFLQENPEILAKAKAEQEAIMRSIPPGQKGLTLRDFRKMAYLSQVVDETLRFVNISFVSFRQATRDVFVNGYLIPKGWKVQLWYRSVHMDPQVYPDPKKFDPSRWEGPPPRAGTFLPFGLGTRLCPGNDLAKLEISVFLHHFLLGYKLTRKNPNCRVRYLPHPRPVDNCLAKITRLSSSHG
What is the function of this protein?
Catalyzes three successive oxidations of ent-kaurenoic acid giving gibberellin 12 (GA12), a key step in gibberellins (GAs) biosynthesis.  GAs, which are involved many processes, including stem elongation, play a central role in plant development.
What are the official names of this protein?
Ent-kaurenoic acid oxidase 1, gpr5.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MOAA2_PSEAE
Sequence: MSDSRLVDPFGRRITYLRLSVTDRCDFRCTYCMSEDMQFLPRDQVLSLEELYAVADAFIGLGVRRIRITGGEPLVRKGITGLLARLGQRAELEDLAITTNGSQLRERAAELKAAGVRRLNVSLDSLQRERFAAFTRSDRLEQVLDGIQAAREAGFERIKLNCVVQKGRNDDEILDLVEYALANQLDISFIEEMPLGSITSHRRELTLCTSDEVRAIIERRWPLTPSLARSGGPSRYYQIGDEPSRIGFISPHSNNFCGDCNRVRVTAEGKLVLCLGHEGALDLRELLRSHPGDRERLSAALVAALNLKPERHHFDAQEQVQVLRFMSMTGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase 2, Molybdenum cofactor biosynthesis protein A 2.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: DAPE_BORPD
Sequence: MTADSAVLALVRELIARPSVTPDDVDCQLLLAQRLEHAGFRCETIARGDVTNLWARRGNAGPLVVFAGHTDVVPPGPRDKWDSDPFVPTERDGYLYGRGAADMKSSIAAFVVAAEEFTAAHPGHDGSIALLLTSDEEGPAVDGTVIVCDELRARGEQPDYCIVGEPTSGDVLGDTCKNGRRGSLSGRLTVKGIQGHVAYPHLARNPVHQLAPALAEMAATEWDRGNEYFPPTTFQVSNLRAGTGATNVVPGEAVVLFNFRFSTASTPEGLKQRVHALLDKHGLEYELDWELGGEPFLTPRGPLTDALVAAIRAETGVAAELSTTGGTSDGRFIAKICPQVIEFGPCNATIHKVNERIELASLEPLKNIYRRTLENLLLPR
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: CEP2_EBVA8
Sequence: MASAANSSREQLRKFLNKECLWVLSDASTPQMKVYTATTAVSAVYVPQIAGPPKTYMNVTLIVLKPKKKPTYVTVYINGTLATVARPEVLFTKAVQGPHSLTLMYFGVFSDAVGEAVPVEIRGNPVVTCTDLTTAHVFTTSTAVKTVEELQDITPSEIIPLGRGGAWYAEGALYMFFVNMDMLMCCPNMPTFPSLTHFINLLTRCDNGECVTCYGAGAHVNILRGWTEDDSPGTSGTCPCLLPCTALNNDYVPITGHRALLGLMFKPEDAPFVVGLRFNPPKMHPDMSRVLQGVLANGKEVPCTAQPWTLLRFSDLYSRAMLYNCQVLKRQVLHSY
What is the function of this protein?
Plays a critical role in cytoplasmic virus egress.  Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid.  Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.  Activates the AP-1 pathway and enhances EBV reactivation and virus release.  Inhibits type I IFN-induced TYK2, STAT1 and STAT3 phosphorylation, thereby impairing type I IFN signaling and counteracting the ability of IFN-alpha to suppress the reactivation of EBV.  Recruits SHP1 phosphatase to dephosphorylate STAT1.  Mediates STAT2 ubiquitination and proteasomal degradation.  Also suppresses type II and type III IFN signaling.  Contributes to G1/S arrest in the host cell.  Acts as an miRNA regulator that interferes with the function of RISC in miRNA-mediated mRNA silencing.  As a result, SUMOylation is increased.  When encapsulated in the exosomes released by EBV-infected host cells, may facilitate the infection in recipient cells.
What are the official names of this protein?
Cytoplasmic envelopment protein 2, Tegument protein BGLF2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.
Protein: TDRD5_XENTR
Sequence: MEQERIMQRIQKDVRALLIASKNGLSIHELEQDYRMMIGSHIPIRSLGYKSTMELLLDMPSVVKIHTQLDGTVKLSAVVDETTRRIADLVSCQKDRCTARTRNRRRNIRPRCPVDLVRRGRVSPVLPATVKSDLRDLLSVSPLLLSELEKAFSSRFGRSFQYTRYGFYSMLEVLRSITDIVEVKQTRAGSLLVLRNSETGRISASLCVKQSQLAIDPKKTSCVLEQCLKEPRTPEKKTSETVTYLKVSPPEPQKLSSKESPSVTRSTSPLINSSNKEQRLKLNVLLDESLKSNENKAPPVTNFTSAVPSHNSVLSNSLVGNSVSSETLFTKMSRPTSHVEADHSAASEPDASVLEWLEKKLEKELKLCLARKGAGGSVSDALRMDIQHVVNQHSDGLKISQLPTVFKSFTGKDLPFKELGFMSVMELVGSLGDILCVESTVDGKDWKLFDAKKKDLVDEFSAGLPSTSSILSSWNSSQQTTTPVKPVGTIFSKVDEKLWWGPLELKLCSTEQIDIPPDAVRNQKLHCLPSMKRGFMIGVYVENIESPSQFYVRCCGKDTSEKLEDMMIEMRHCYSNECVSERYIVTDNCISVGQIYALRVPGDVWWYRVIVHDIKNSELLDVFYPDFGNVATVKKSWLRFLKNCYMKIPAQAVPSSLPYVTSTEDQWSAQAIKKFQQLCSCIPLVGMVLQYVQDILHIFLCDTSSEEDLYLHQLLISQGLAKMEPEHACKKISKKRNPFMQYLTPSQEQPQEESSQLSVPSESSQSEIPCAKEVKDEDDLGMPYLEAFPSGSDVWDENWAFSDGACDYDTAPTIPKVDTQKQQENKVSQETQPFKFCIDSADASVVHHPLEEFYISLIKSRKSQESTDIQQSPPTEEQHVAEISHRSATEQLQGGSSSSMLCEKKLYYEKEDLPYCQQSKCSFSPLLGFQRLQIPRSATPVALGPAARLATAGRLLYWASEPR
What is the function of this protein?
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity.  Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).
What are the official names of this protein?
Tudor domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the TDRD5 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.
Protein: NIGP_LACP7
Sequence: MNWTLTNSSLDKDSITSNGNRFLIGNGYLGIRGTLEEYRKEYFPAINLAGIYDQVGEGWREPLNAPNALYTRIEVDEVEYQLPKIEPRYHELSLDYRHGILDRQTVWASNKGTIIVKSSRFASMKEKHLVVLNYSITADYDCEIIVYTGIDGSVWDIHGPHYDKVEFQKQLLRHNETEILNEKYLLESESKWNGHRLSIAAQTHENKDIVYVTEDIICNKEAKIELIESDKECLRKLTFHGKAKEEINFTKYITVFTSKDCVDYKEQSIKIVNHAKDTGYERLQEEHKNVWEQLWNISEVTIEGDDEANDALNYSLYHLHCIAPRHSKSLSIAARGLSGQTYKGAVFWDTEMFMLDFFLYTQPEVAKTLLRYRIDTLEGAKKKAKLYGYEGAFYAWESQEGGYDACSDYNVTDVFTKRPMRTYFKDKQVHISSAIVYGIRSYLNYTNDFSILAEGGAETILECAKFYYSLLEKKIGKEYYEIHDVIGPDEYHERVNNNAYTNRMAKLTFETAIDILDHEKNKDEEFYIKLLKQYEIKDLLDKLKDACNKLYIPKPKDNSDLIEQFDGFFELEDVSLEEVRSRLLHEKEYWGGAYGVASHTQVIKQADVVTMLVLFKEEYQREVLQQNLNYYEPRTEHGSSLSACMYSLLYCMCDQPQYAYPFFMKSALADWNGKGKEWAGLVYIGGTHPAAAGGAYMTAIKGFGGFQIENGVIKATPRLPKHWVRLKYRVLYQGAIYEIDASKEQVSISKIEM
What is the function of this protein?
Catalyzes the reversible phosphorolysis of nigerose.  Also shows a weak activity on kojibiose.
What are the official names of this protein?
Nigerose phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 65 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_SYNJB
Sequence: MPYTSAFLEVIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPVNLPIIERIVRSLAIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFPGRVWVGIDARQGQVATRGWLSTTPLRAPELVQRVQAQGAAGIIYTDISRDGTLAGPNLEQLRQILAVSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQEALRAVGPGRWQDLPPETGSLWA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_RICPU
Sequence: MLKDQNLDIERKQDHIEINLTKNVESTLKSGFESIHFIHNALPEINYDSVNTTTTFLGKSLQAPILISSMTGGTTRARDINYRLAQVAQKAGIAMGLGSMRVLLTEPDTIKTFAVRHIAPDIPLLANIGAVQLNYGVTPKECQYLVDAIKADALILHLNVLQELTQPEGNRNWEKLLPKIREVVHYLSIPVIVKEVGYGLSKKVAESLIEAGVKVLDIAGSGGTSWSQVEAYRATNSLQNRIASSFINWGIPTLDSLKMVREVSKDIPIITSGGLKSGIDGAKAIRIGANIFGLAGQFLKAADTSESLLFEEIQLIIEQLKITMLCTGSRTLKDLAKAEIRL
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.