PharMolix/UniProtQA huggingface dataset:
Protein: CLPP1_SYNJB
Sequence: MPIGVPRVPYRLPGEPYSQWISLDDRLYQERILFIGEPIDDSLANTIVGVMLYLNSQDPQKDIVMYINSPGGSVTAGMAIYDTMNHIKPDIVTVCVGQAASMGAFLLAAGTKGKRFALPHSRIMLHQPSLGTIQGQASDIEIRARETLRVKRRMNEILAQTTGQPLEKIERDVERDFYLSATEAQAYGIVDRVIQERSEAMAS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_BURTA
Sequence: MSEIRKNDHRLMQVLLAPVISEKATLVADKNEQVVFEVAPDATKQEVKAAVELLFKVEVDSVNVLVQKGKQKRFGRSMGRRKDVKKAYVCLKPGQEINFEAEAK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: TMEDE_DROER
Sequence: MRDQFISLALMLCILHSACGLYFHISETERKCFIEEVPDETTVIVNYKVELYDPRSNGFMPSSPGIGMHVEVRDSDDKIVLSRVYSSQGRISFTSHTPGEHVICMYSNSTAWFSGAQLRVHLDIQVGEHAIDYANVAQKEKLTELQLRIRQLLDQVEQITKEQNYQRYREERFRHTSESTNSRVLWWSLAQTVVLVCMGFWQMRHLKSFFEAKKLV
What is the function of this protein?
Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo.  Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.  Involved in Golgi organization (By similarity).
What are the official names of this protein?
Transmembrane emp24 domain-containing protein eca.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: Y870_ARCFU
Sequence: MESHHKWGIAFIAAGLALEILFPVLLVFDTILIVVGIALILFGGREKKIEGVS
What are the official names of this protein?
Uncharacterized protein AF_0870.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HBB_LATCH
Sequence: VHWTETERATIETVYQKLHLDEVGREALTRLFIVYPWTTRYFKSFGDLSSSKAIASNPKVTEHGLKVMNKLTEAIHNLDHIKDLFHKLSEKHFHELHVDPQNFKLLSKCLIIVLATKLGKQLTPDVQATWEKLLSVVVAALSREYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: UGT79_ORYSJ
Sequence: MGSMSTPAASANGGQVLLLPFPAAQGHTNPMLQFGRRLAYHGLRPTLVTTRYVLSTTPPPGDPFRVAAISDGFDDASGMAALPDPGEYLRTLEAHGARTLAELLLSEARAGRPARVLVYDPHLPWARRVARAAGVATAAFLSQPCAVDLIYGEVCARRLALPVTPTDARGLYARGVLGVELGPDDVPPFVAAPELTPAFCEQSIEQFAGLEDDDDVLVNSFSDLEPKEAAYMESTWRAKTIGPSLPSFYLDDGRLRSNTAYGFNLFRSTVPCMEWLDKQPPRSVVLVSYGTVSTFDVAKLEELGNGLCNSGKPFLWVVRSNEEHKLSVQLRKKCEKRGLIVPFCPQLEVLAHKATGCFLSHCGWNSTLEAIVNGVPLVAMPHWADQPTISKYVESLWGMGVRVQLDKSGILQREEVERCIREVMDGDRKEDYRRNATRLMKKAKESMQEGGSSDKNIAEFAAKYSN
What is the function of this protein?
Involved in the detoxification of the Fusarium mycotoxin deoxynivalenol by the transfer of glucose from UDP-D-glucose to the hydroxyl group at C-3, forming deoxynivalenol-3-O-beta-D-glucoside.
What are the official names of this protein?
UDP-glycosyltransferase 79, OsUGT79, Deoxynivalenol-UDP-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: ISPE_SYNR3
Sequence: MSSLSLRAPAKINLHLEVLGLRDDGFHELAMVMQTLDLADELAVDSAPAGELSLSCSDPQLPVDGSNLIVKAAEALRRHCGRPELSAQLSLTKRIPIGAGLAGGSSDGATALLLLNRYWDLQLSAAELHNLAAQLGSDVAFCLQGGTQLCFGRGERLEAIAVAAKPAVLLIKNPNVSVSTPWAYGLCKERLGSGYLSSEADFERQRQALRQSPLLAWLKAEQQQLPPLRNDLQQVVAPENASVQKGLALLASAGDPLQVAMSGSGPSLFALYRDQPAAAAAQSALAPALAENGFEHWICQSTAERHG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PSBF_GLOVI
Sequence: MTTSSNRPTPGGPTQPVSYPVFTVRWLAVHALTVPTIFFLGALAAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CCL16_HUMAN
Sequence: MKVSEAALSLLVLILIITSASRSQPKVPEWVNTPSTCCLKYYEKVLPRRLVVGYRKALNCHLPAIIFVTKRNREVCTNPNDDWVQEYIKDPNLPLLPTRNLSTVKIITAKNGQPQLLNSQ
What is the function of this protein?
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils.  Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells.  Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils.  Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
What are the official names of this protein?
C-C motif chemokine 16, Chemokine CC-4, HCC-4, Chemokine LEC, IL-10-inducible chemokine, LCC-1, Liver-expressed chemokine, Lymphocyte and monocyte chemoattractant, LMC, Monotactin-1, MTN-1, NCC-4, Small-inducible cytokine A16.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y867_METTH
Sequence: MNTREVELRGHIIDSLILPRALDIIMDMGGDFQILEIDIGKRKSDPSHARILVEAETPSLLNQILDELGEIGASIAEIKEAELRRAPMDRVLPDDFYSTTNHQTFIYHGGEWVEVEGIEMDCMIVVDPESRTARCKPIREIKKGDLVVVGREGIKVVPPERPRGKQGVFEFMGSEVSSEKPLVTTIKKIASEITEIKKRGGRIGLVGGPAIVHTGSAPVIAEMIRLGFIDVLFAGNALATHDIECALYGTSLGVDIDRGEAVSRGHRHHINAINEINRAGSIRDAVEQGVLTSGIMYECVKNDVPFVLAGSIRDDGPLPDVITDVMEAQNEMRKYVQDLDMVIMIATMLHSIATGNILPSRVKTICVDINPATVTKLSDRGSSQAVSVVTDVGAFIPILLHEIKKMNGLGD
What are the official names of this protein?
Uncharacterized protein MTH_867.
Protein: ACPH_ECO45
Sequence: MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRNETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFTCYAREQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQSVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMEQASRKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: MMM11_YARLI
Sequence: MSQFVLPAVASEGIINWPFLTGFMLGQFSVGLVLLIFVRFFIFSDQTEPDINTQRRTAKVLPTGNPSTDAILEKTYYNTKTHQPESLDWFSVLVAQALYQLRDEVRGNDEVLERLNEILKSDKLPGFLDTINVVDLDIGDAFPQFGACKVNKDESGDLEAEIKVSLEDTIKLGVETKMLLNFPIPKFASVPVSLSVSLVKFSGTLTVAIRSAFNSGEANRVLVSFAPDYELQWKIESSVGSTQKLQNAEKISRLIESRIRRWFKDRCVYPEYQQFELPKLWRKTSAPPPSAGAGTGTSTGVPPSPFPQPANPSSVPKPLELPGGFPHRNMSMSSQRPNINNPKFIRSMSVNTRPTYSSSFYEMQGTAGSSSGSAVADEAYRSLQTSPRR
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  The MDM12-MMM11 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Maintenance of mitochondrial morphology protein 1-1.
What is the protein family that this protein belongs to?
Belongs to the MMM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: RS15A_BRANA
Sequence: MVRISVLNDALKSMFNAEKRGKRQVMIRPSSKVIIKFLIVMQKHGYIGEFEYVDDHRSGKIVVELNGRLNKCGVISPRFDVGVKEIEGWTARLLPSRQFGYIVLTTSAGIMDHEEARRKNVGGKVLGFFY
What are the official names of this protein?
40S ribosomal protein S15a, PPCB8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PO14_NASVI
Sequence: PFADDLAVLVEGDSRAEIEKVGKAVVKHIVERCSAIKLEVSESKTVGIFVKKPKVVGSKAVKINRKDCRKGGARNLKIELGGKSISFEQSVRYLGVHFDANLGISAHCKYLREKLVPLFSDLRKLAQCQWGLGHKALETIYKGVFVPTVCYASARWYKEGAHTDRILEDLHRQILIAITRCYRSTSYEAACVLAGTLPICIQLRVSVAKYHLRKGEDAEIGGVVIRRRPEGLKENYNRVLEVANEMWQARWEASEQGNATRELFFPDVVARVKSDWIRPDHFTSQVLTGHGYYNEKLHQLSLAKAAACICCGEPDNNLHFLLECPAFAEFRDELITPVSGGLEAPEATLMLVSSPEGFAALKEYSRVAFECKRQLENALTESDEGLSSESEE
What are the official names of this protein?
Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 4, Retrovirus-related Pol polyprotein from type I retrotransposable element R1 4.
Protein: EZRA_BACAH
Sequence: MDSILTIVIIVVSSILVLLMIELVIRNRSYKDIEALEQWKQEIKDKPVADELKRVKDLNMTGQTEELFGKWREEWDEIVSTTIPKADKDLAQARKFASQFSFRKAKHAMNESISGLDDADNRITDILNELQQLLESHEKNSSEIEGLRDTYRSMKKSVLAHRHMYGAAEQKIEEMLDAESEKFKTFEEATNNGDYLKAREIVISLEEGLADLEIIIHQIPDLLVECQATLPVQLEDLLHGHNDMVRQGYVLDYLEVPKEVRDMTKQLQTCLIDIQELHITEAAEKVENLKTRLDGFYDQLEQEVHARHYVEQKTLSVYEDLEEIRTETIETKAETQLVKQSYQLQDKDIESQKVIEKQMHILTKRFEMLQLRVAEQDIAFSIIREELEEIYEQCETLKVLHAEYKEMLQTMRKEEFEAREKLQEMRNTIFETKRFMQKSNLPGLPESIMEDLKRGQMAMQAVYEQLEVKPLNMNAVNSSLEEAYTTVNGVAEMTEELIGQAYLVEKLIQYGNRYRSHDENLAESLNYAEKLFREYQYDAALEQAASVLEQLEPGVVQKIAEYVDNEQTLS
What is the function of this protein?
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation.  Inhibits FtsZ ring formation at polar sites.  Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
What are the official names of this protein?
Septation ring formation regulator EzrA.
What is the protein family that this protein belongs to?
Belongs to the EzrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Colocalized with FtsZ to the nascent septal site.
Protein: Y2456_DICDI
Sequence: MENNNGNSVINKSNDKNSNNPNYMLLDRIFRLQKHNLSILLSNNNNNNNNNNNNNSNITIQSATNYLNELLNCLNELLTKFQSKTFQSPPQPINTSSTQTNYNNQNNPNPNPNPSPNPNSNNNNNNNTHITIILSTEIIIKILVKFCSVLPMDINYHKISVYGSPINLSLIQLPLKLAQLIVLISRYQNSITFNDHPNELEQLVNYFLYIIKPEKQIASSPSTPSTPSSSSRSQQQQQQQQQQSSSSSLSSSSSFHNVNTNLRIESLKALSSLLHNNGPNITSKLQQPLIECLIELSNYSDQSIDQETKRIAIVSLGNLCMQCGTKLSKYYIQIYDRLSLNLERVTSHINSDKYLIKFTSSILRSMQLLITQAKGILDQKSKSLYNILKTLMFYGVNISSSMSSVLTYQYQFEYSSRKKKQLQQQLANNNVLNSNSNSSSGGASSSSGGSNNTSPAIVTSASIHNSNGNSNENEIEKSTGITSSDSDIDERYNLSKLRFLTITLLNTMAKHSPKVFFGYWTLFLPSTPFPLTPTVFTSMTNDPDIKIKIVAANFLQTIIDGSKDYLVAINTSNHHNHHHSHSKSITTASPIMSRLNLNDNNNNNINNLNSNSFTTFSQNLTSILKEIHNGLIMILVQDPNYILPAFHQQILRCVSTLIINCPYEKLNMPSLLTSLLSAISPYIQNRDHSIQLTSLICIKQLFDITPLSPKELTPVLNNNNFIKIILNFLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNILSNTLTSSLINEPNQQHQHQQHQQQNQQHHHQHQQQSLHFNQIEYVKIECLQIIGALTKHNFTILLEYIDLVYNILISILKKEISIHNSSGIVNSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHNNTQNINNISGLNESSIGNYCLKTFEEITKAIQDSHKNNNTDIDYKICEKEFWNLFFLILPSLTVDPYPQIRASICNIFSNIGSKQFESMTKNLQMHLVSVVLGLIFDEQHIVRASACRSVGILIKIDSLHDDANFLSNSASCLTKSMGDVNINVRIKACWSLANLCDHLVSLKSKQELLFNDIPRQILSKVLESLLNSSFDNPKIRSNVVRALGNFARFADKKVLYNLNETSTFCKINENNNQNYNNQNISDYFHSIGGFNNLMNGVGGGGGSSSSGGGNGSGTIIPTTEEEEEKEEINIENKQKQSLPPQFSNSITLKKDSIILDRIVDSLLKNAQEPSSSFNFVKVKWNACYALGNIFYNQDIEFPNDDNNNNNNNNNKWLPQVYSTLITLMKSCKNFKTRINATSSLATPTHSRRKYGPFYKDVFEAVLESLSNINTVSDTSEFQYRDNLEKQLEIALIHLISEMKSNEIKSFDNCFFQYTDIIVNSFQKHQIILPIPQQPLPTSKTSSSSSSTSSEATPYLSSSVPPSIVTSTPSTTPMISSSNPNTSSLPTSERPTIKEYQKALEIIKEFCQNHNNIDTMDDTQKLHLSQLCLLFDFSESNYQDMYSKLQEVHSTGKSSH
What are the official names of this protein?
Putative uncharacterized protein DDB_G0272456.
Protein: TIG_MESFL
Sequence: MKFTELKIIEQGQGKWTVTIDGTEWTETLKKAKNRVLANLEVPGFRKGKIPAAQAEKYVTPSKIYNEAYRMMVSPAFDFARAQEVKVEPMNSPEPIPAKVSEKELVIEFLFDLKPEIKLGDYKNIKTVKKETVEVTKEEIEAVIDQYCEQFIMEKPKAADAKIEKGDIVTFDFKGFMNGEAFKGGEAKGHKLVIGSNQFIPGFEDSMIGLGLGEAKIDVTFPEGYTPELANKPATFELNIIEVKARELPKKDDELVKDLNLPNVETFAQFEAKVKEDITKQKLQNVKNQFVNDLINEIIKNSTIELPKTAIENQTADLRKEFEAQLKQQGLDIKKYKKVTGLSDEAIKAELTADAKNKLETYLVTSEIRSKEKFEVTEEAINAKFENLAAQFGIPADQIKTMVNPEMLKSEIVNDLLVDFLYSNNG
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: YDGC_SHIFL
Sequence: MGLVIKAALGALVVLLIGVLAKTKNYYIAGLIPLFPTFALIAHYIVASERGIEALRATIIFSMWSIIPYFVYLVSLWYFTGMMRLPAAFVGSVACWGISAWVLIICWIKLH
What are the official names of this protein?
Inner membrane protein YdgC.
What is the protein family that this protein belongs to?
To P.aeruginosa GlpM.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VE1_HPV27
Sequence: MEDSEGTDGTEEDGCRAGGWFHVEAIITHGQRQVSSDEDEDCTETGEDVDFIDNRVPGDGQEIPLQLYTQQIAQDDEATVQALKRKFVASPLSACSCIENDLSPRLDAISLNRKSEKAKRRLFETEPPDSGYGNTQMVVGTPEEVTGDENSEGGRPVEDKEEERQGGDGEADLTVQTPQSGTDAAGSVLTLLRSSNLKATLLSKFKELFGVGYYELVRQFKSSKTACADWVVCAFGVYYAVAEGIKQLIQPHTQYAHIQVLTCSWGMVVFMLLRYNCAKNRDTVSKNMSMLLNIPEKHMLIEPPKLRSTPAALYWYKTAMGNGSEVYGETPEWIVRQTLVGHSMEDEQFRLSVMVQFAYDHDIVEESVLAFEYAQLADVDANAAAFLNSNCQAKYVKDAVTMCRHYKRAERAQMSMSQWITFRGNKVLEEGDWKPIVKFLRHQGVEFVSFLAAFKLFLKGVPKKNCIVFYGPADTGKSYFCMSLLQFLGGAVISYANSSSHFWLQPLSDSKIGLLDDATPQCWSYIDTYLRNLLDGNPVSIDRKHKTLLQLKCPPLMITTNINPLEEDRWKYLRSRLTLFTFNNPFPFASPGEPLYPINNANWKCFFQRSWSRLDLNSPEEQDDNGNTSEPFRCVPGDVARTL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: EXPB_PASNO
Sequence: GPPKVAPGKXISASFGGEWL
What is the function of this protein?
May aid fertilization by loosening the cell wall of the stigma and style, thereby facilitating penetration of the pollen tube.  Acts selectively on grass cell walls, which are relatively poor in pectins and xyloglucans and rich in glucuronoarabinoxylans and (1-3),(1-4)-beta-D-glucans, when compared with cell walls of other angiosperms, including other monocots (By similarity).
What are the official names of this protein?
Expansin-B, Beta-expansin, Pollen allergen Pas n 1.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin B subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.
Protein: LTE1_KLULA
Sequence: MSEVVEKADENVVPLFSRPELYPVPSESVLTVDLRDGTVRILKCTLPALLVQLSSPLDKVDYSMLTDFFLVYRNFMSSQKLLDLIQERFQWAIDLRQSDPSSQEKITSEVILVRMFVLVRHWLSNYFAQDFVVDTSLRRQFLQFINGYSPVDRFLDNIIISLKKLWVQNVQIMWEDLENLIVENNVVSRDDWLKWEIEDVPSGSSSETGEGSTKGKRLSFIALQNINNPVLRNESLLSLLHTREKIPLPQQSEDESKKQSTRIKQRTGSMLLFPENASNGLSINEKLTASGVSPEATPKQEREITDPKNSKDNKHILPQLSRVTNVSYMMKDLEYPSTPSVDIFVPPTPAKNIEFILQTSYMETDLPEQSNGSDSTNTVNGNNTNHKGILGLLSKWKLNHQRKPTVNPVQNPPRVENLIKYVFSISSLDNHANPLPDSLSSMFDILSARTIDEVEYLVSVESDLLAKLEAKKLTTEISKLETNEDESQDYSVIDNLNLYKTVSSIANSVISLSKTLNVRTNKSTTHLLSPSTSALERKNIRNSAPMLYSYNNSRYSITNALMGLPNTNDNSSPKRLVFHDPTRNSPTKKAILANNLNNIGEYNGERDSITSIVTYDSAFSDISSSGNILSQHKGSSNIFMESAPTLKRKLNVNDLRRFNFEKSDSTDDRSCSPQNREATETSATSMESDANDNAIQDEYENENEDIASLITAYEESTSEIDTQCQNNAQIRRPTSGRISITRNYSVASPNSLRSILPKSPLILGNEVFIERDKALAANQDIISELEETTSLLLNDNDRKFTVSRGSVCNDSDSQSISTNLLFSSAQASPQKLVIKEVDVIQEKSEHPDVPTPVLCKQPISKLSETPSIKSIGSRDSEESFDLTSIASKPNRAQSTTLREKYHLEKQATNDIFEEDVENLNPENNKYLFSPDTDSIDFASPEKNLDDLKQQFIDQSTDEQTSLDEEEIATQDNENKDHGIDKKKLEDIMNGIDDTADTSMDPVNLALMKLEGTYDKGEKEIDDKSPSINSELAREVENFQIVQTAALPESARKRQSMFIQRRRNTMIDFSVRDSLIDKDSSCTRLENTDEQIRNLLNQYTLTDSRLKIDNLEQHIPFILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLAIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIEKRTWIVHDEVLNYNKFQTNVQIVKNFVQKMQWSKFYNIDIDHELLSKCVYITSLSHDEINSISHKSPI
What is the function of this protein?
GDP-GTP exchange factor component of the mitotic exit network (MEN).  Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis.  May also be involved in proprotein-processing in the secretory pathway (By similarity).
What are the official names of this protein?
Guanine nucleotide exchange factor LTE1.
What is the protein family that this protein belongs to?
Belongs to the LTE1 family.
What are the subcellular locations of this protein?
Cytoplasm. Bud.
Protein: ERPA_RALSO
Sequence: MNAVAQAATPDVNEVPAPLVFTDSAADKVKQLIEEEGNPELKLRVFVQGGGCSGFQYGFTFDEDTNEDDTTMTKNGVTLLIDSMSYQYLVGAEIDYKEDINGAQFVIKNPNASTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: AGIB_ASPFN
Sequence: MRMLVSKSIFAEPEPGYYAHTPVSLVICAPNMPDLLSHRLEDGFRAASRHAEALAKLQYRDPNAKDVLGFQLAFSTTKSYWDYVEEDDPECGQRFSKAMRAVTVNKLGDVPKLYPFNKLVDDGGIIVDVGGGMGQVAQSILSHWHGLGLKCIVQDKFASKSGSTHPDLEMQSYDFFSPQPVKGSAAYLFRHIFHDWPDDACITILKNTVEAMNPHQSRILICDQIMEETNPSTAAVLYDIDMMCLYGGKERTLSEWEELLKAADQRLEIKNVFRSPNQVSGILEVQLCCD
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the aspergillicins A and F, 2 cryptic cyclic hexa-depsipeptides (PubMed:31117395).  The hexamodular NRPS agiA catalyzes the condensation of the six amino acid residues including N-Me-L-O-Me-tyrosine, L-proline 1, L-proline 2, D-isoleucine, O-acetyl-threonine, and L-isoleucine (PubMed:31117395).  The starting condensation domain (C1) of agiA probably loads acetyl-CoA which is condensed on the N-terminus of threonine by the first module to yield O-acetyl-threonine (PubMed:26273902).  The second module then loads L-isoleucine.  The epimerase (E) domain on module 2 is probably involved in the formation of the D-isoleucine moiety (PubMed:26273902).  Modules 3 and 4 further load 2 successive L-prolines (PubMed:26273902).  Module 5 is then involved in the condensation of O-Me-L-tyrosine produced by the O-methyltransferase agiB and the N-methyl transferase (NMeT) domain on module 5 probably catalyzes the N-methylation to yield the N-Me-L-O-Me-tyrosine moiety (PubMed:26273902).  The A domain of module 5 loads preferentially O-Me-L-tyrosine, but it can also accept L-phenylalanine, which leads to the production of aspergillicin G (PubMed:26273902).  Module 6 then loads the last residue, L-isoleucine (PubMed:26273902).  The C-terminal thiolesterase (TE) domain probably cyclizes the peptide using the hydroxy group from threonine to form the cyclic depsipeptide (PubMed:26273902).
What are the official names of this protein?
O-methyltransferase agiB, Aspergillicin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: NUD16_HUMAN
Sequence: MAGARRLELGEALALGSGWRHACHALLYAPDPGMLFGRIPLRYAILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGEAAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAVEAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSFIGSAREQLLEALQDLGLLQSGSISGLKIPAHH
What is the function of this protein?
RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner.  Part of the U8 snoRNP complex that is required for the accumulation of mature 5. 8S and 28S rRNA.  Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA.  Catalyzes also the cleavage of the cap structure on mRNAs.  Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG).  Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies.  Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species.  Binds to the U8 snoRNA; metal is not required for RNA-binding.  May play a role in the regulation of snoRNAs and mRNAs degradation.  Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms (PubMed:20385596, PubMed:26121039).  The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP (PubMed:20385596).  Binds strongly to GTP, ITP and XTP.  Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (PubMed:20385596).  Exhibits decapping activity towards NAD-capped RNAs and FAD-capped RNAs (PubMed:32432673).  Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).
What are the official names of this protein?
U8 snoRNA-decapping enzyme, IDP phosphatase, IDPase, Inosine diphosphate phosphatase, Nucleoside diphosphate-linked moiety X motif 16, Nudix motif 16, Nudix hydrolase 16, U8 snoRNA-binding protein H29K, m7GpppN-mRNA hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NUDT16 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm. Note=Localized predominantly in the cytoplasm (PubMed:21070968). Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm (By similarity).