PharMolix/UniProtQA huggingface dataset:
Protein: SYW_BORPE
Sequence: MNTRVLTGITTTGTPHLGNYAGAIRPAIQASTQPGVDAFFFLADYHALIKCDDPARVARSRLELAATWLAAGLDPERVTFYRQSDIPEITELCWLLTCVTPKGLMNRAHAYKASVDQNAAKGVEPDDGVTMGLFSYPVLMAADILLFNANQVPVGRDQVQHLEMARDIAQRFNHLYGREFFVLPEVVIAEEVATLPGLDGRKMSKSYNNTIPLFEGGAAGLRNATQRIVTDSRLPGEPKDAEASHLYMLYRAFSTQQESMAFRRQLEEGMGWGDAKQALYERLERDLAPMRERYVELISNPGLIEDILQVGAAKARKLAQPLVRTLRDAVGLGVLQPAAAKAAQPARKAAKDARFVSFRDEDGSFRFRLLAADGEELLCSVPFANPKEAGALMRRLQDEAPEQALRGHDDVSYAAWLDGKEVAYGPQAADAGARDALLAKAREALAQLAAA
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSTT4_MOUSE
Sequence: MGLELYMDLLSAPCRAVYIFARKNGIPFDFQFVDLLKGHHHSKEYIEINPLRKLPSLKDGKFILSESVAILFYLCRKYSAPSHWYPPDLHMRARVDEFMAWQHTAIQVPMSKILWIKLIIPMITGEEVPTERLEKTLDEVKRNLQQFEEKFLQDKMFITGDHISLADLVALVEMMQPMGSNHNVFVSSKLAEWRMRVELAIGSGLFWEAHERLVKLPNWDCSTLDPTIKMRICDFLQKFK
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase theta-4, GST class-theta-4.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_CLOBK
Sequence: MKDNIELTIFTPEKNIKIGEIKEVITEGLDGDLAILPNHVNMITYLKPTITKYIDLNGNKNNIFTSSGVLKVEDNKVYIICDASEKPEDIDIKRAENAKKRAEERLRNKKEIDVKRAELALFRSIARIKIKEL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PURA_ALKMQ
Sequence: MPSIVIVGAQWGDEGKGKIIDYLAQEADVVIRAQGGNNAGHTVMVEDKKYSFHLLPSGVLFEDKLNIIGNGVVFDPEGFLQEIEVLKKEGINTSNIKIDERVHVIFPYHKRIDQLEEEARGEAQIGTTKKGIGPCYMDKIQRSGIRLGEMIDEEDFKDRLYKQVDDKNKIIEKIYEAEGFEKEAMYETYLKYAREIKKYVTDTTILAHEALKAKKKVLFEGAQGTLLDIDLGTYPYVTSSHPTAGGFPIGAGIGPNQIEQVLGIVKAYTTRVGSGTFPTELDNEVGDKIRIKGNEFGTTTGRPRRCGWFDGVMVRYTTRINGLTAMSLMLLDVLSGFDTLKICTGYELEGEMVAHFPANIKTLGKCKPIYEELPGWEEDITNMKTYEELPENAKKYIERIESYVGVPIKMISVGPKRNQTIIRERLF
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_BUCAI
Sequence: MSILHNIVSKKELKRRMFFETEPRLTLSFYKYFFIKNTQEYRDRLYKTFYKYNVLGRIYVASEGINAQISVPKKYYSILKKFLYNFDIELNNLRINKSLDNEKSFWVLCVKIKKKIVQDGIKEHFFNPNNVGIYIQSEQVNSMLNDKKTIFIDMRNSYEYAIGHFENAIEIKSITFREQLKKVIQLMAYAKNKKIVMYCTGGIRCEKATSWMLFNGFKHVYHLEGGIIGYVHDARKNGLPVLFKGKSFVFDNRMSEKISDEVISYCKQCGKSSDVYINCKYSSCHLLFIQCENCSVKFHSCCSLECMKKYKFYMLNNDLKKISY
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: KAIC_SYNE7
Sequence: MTSAEMTSPNNNSEHQAIAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGIIEFDEPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDASPDPEGQEVVGGFDLSALIERINYAIQKYRARRVSIDSVTSVFQQYDASSVVRRELFRLVARLKQIGATTVMTTERIEEYGPIARYGVEEFVSDNVVILRNVLEGERRRRTLEILKLRGTSHMKGEYPFTITDHGINIFPLGAMRLTQRSSNVRVSSGVVRLDEMCGGGFFKDSIILATGATGTGKTLLVSRFVENACANKERAILFAYEESRAQLLRNAYSWGMDFEEMERQNLLKIVCAYPESAGLEDHLQIIKSEINDFKPARIAIDSLSALARGVSNNAFRQFVIGVTGYAKQEEITGLFTNTSDQFMGAHSITDSHISTITDTIILLQYVEIRGEMSRAINVFKMRGSWHDKAIREFMISDKGPDIKDSFRNFERIISGSPTRITVDEKSELSRIVRGVQEKGPES
What is the function of this protein?
KaiC is important for metabolic partitioning during the dark to light shift, modulating the balance between the Calvin cycle and oxidative pentose phosphate pathway under natural growth conditions.
What are the official names of this protein?
Circadian clock oscillator protein KaiC.
What is the protein family that this protein belongs to?
Belongs to the KaiC family.
Protein: RUN3A_MOUSE
Sequence: MEASFVQTTMALGLPSKKASSRNVIVERRNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPASWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDNRTTRRFYDSGAIMLREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYNKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPGDHAPLAQGSKELTTSLVNQWPSLSTLHRPEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEAKRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS
What is the function of this protein?
May act as an effector of RAP2A in neuronal cells.
What are the official names of this protein?
RUN domain-containing protein 3A, Rap2-interacting protein 8, RPIP-8.
What is the protein family that this protein belongs to?
Belongs to the RUNDC3 family.
Protein: RNPH_BORPE
Sequence: MSTSAADTLSRPSGRAVDALRPFSLERGFTRYAEGSVLVRAGNTHVLCTASVLEKVPPFLKGRGEGWVTAEYGMLPRATHTRGDREAARGKQSGRTQEIQRLIGRSLRAVFDLRLLGERTLHLDCDVLQADGGTRCASITGAWVAAADAVALLMQRGDLAHNPIRDAVAAVSVGLVDGRAVLDLDYQEDSACAADVNVVMTGSGAFVEVQGTGEGATFTRGELDTMLGLAEGGIAQLVRAQREALQ
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: YAP5_YEAST
Sequence: MALPLIKPKESEESHLALLSKIHVSKNWKLPPRLPHRAAQRRKRVHRLHEDYETEENDEELQKKKRQNRDAQRAYRERKNNKLQVLEETIESLSKVVKNYETKLNRLQNELQAKESENHALKQKLETLTLKQASVPAQDPILQNLIENFKPMKAIPIKYNTAIKRHQHSTELPSSVKCGFCNDNTTCVCKELETDHRKSDDGVATEQKDMSMPHAECNNKDNPNGLCSNCTNIDKSCIDIRSIIH
What is the function of this protein?
Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements.  According to genome-wide promoter binding and gene expression studies it is a coregulator for the expression of ribosomal genes, while its own expression is induced by the cell cycle specific activator SBF (SWI4-SWI6).
What are the official names of this protein?
AP-1-like transcription factor YAP5.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. YAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CYT2_ORYSJ
Sequence: MRASSLFAESVFTTSAAAGRRRCPRLAAVPVTLFFSTGRGSPAMAEEAQQPRGVKVGGIHDAPAGRENDLTTVELARFAVAEHNSKANAMLELERVVKVRQQVVGGFMHYLTVEVKEPGGANKLYEAKVWERAWENFKQLQDFKPLDDATA
What is the function of this protein?
There are two distinct cystatins in rice seeds (Oryzacystatin-1 and -2) with different specificities against cysteine proteinases.  May be involved in the control of germination by inhibition of endogenous cysteine proteinases.  May play a role in defense by inhibiting exogenous proteases such as those present in digestive tracks of insects and nematodes.
What are the official names of this protein?
Cysteine proteinase inhibitor 2, Oryzacystatin II, OC-II, Oryzacystatin-2.
What is the protein family that this protein belongs to?
Belongs to the cystatin family. Phytocystatin subfamily.
Protein: ENPL_HORVU
Sequence: MRKWALSCALLLVLLLTTLPDPAKKLQVNAEESSDEVGDFPKVEEKLGAVPHGLSTDSEVVQRESESISRKTLRNSAEKFEFQAEVSRLMDIIINSLYSNKDIFLRELISNASDALDKIRFLALTDKEVMGEGDTAKLEIQIKLDKENKILSIRDRGVGMTKEDLIKNLGTIAKSGTSAFVEKMQTGGDLNLIGQFGVGFYSVYLVADYVEVVSKHNDDKQYVWESKADGSFAISEDTWNEPLGRGTEIKLHLRDEAKEYLEEGKLKDLVKKYSEFINFPIYLWATKEVDVEVPADEEESNEEEESTTETTEEEETEDDEEKKPKTKTVKETTTEWELLNDMKAVWLRSPKEVTEEEYAKFYHSLAKDFGDDKPMSWSHFSAEGDVEFKALLFVPPKAPHDLYESYYNANKSNLKLYVRRVFISDEFDDLLPKYLSFLMGIVDSDTLPLNVSREMLQQHSSLKTIKKKLIRKALDMIRKLAEEDPDEYSNKEKTDDEKSAMEEKKGQYAKFWNEFGKSVKLGIIEDATNRNRLAKLLRFESSKSDGKLVSLDEYISRMKSGQKDIFYLTGSSKEQLEKSPFLEQLTKKNYEVIYFTDPVDEYLMQYLMDYEDKKFQNVSKEGLKLGKDSKLKDLKESFKELTDWWKKALDTEGIDSVKISNRLHNTPCVVVTSKYGWSSNMEKIMQAQTLSDASKQAYMRGKRVLEINPRHPIIKELRDKVAQDSDSEGLKQTARLVYQTALMESGFNLPDPKDFASSIYRSVQKSLDLSPDAAVEEEEEVEEPEVEEKESAKQEAEEPEHEQYDKDEL
What is the function of this protein?
May have a molecular chaperone role in the processing of secreted materials.
What are the official names of this protein?
Endoplasmin homolog, Glucose-regulated protein 94 homolog, GRP-94 homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: ISPD_ARATH
Sequence: MAMLQTNLGFITSPTFLCPKLKVKLNSYLWFSYRSQVQKLDFSKRVNRSYKRDALLLSIKCSSSTGFDNSNVVVKEKSVSVILLAGGQGKRMKMSMPKQYIPLLGQPIALYSFFTFSRMPEVKEIVVVCDPFFRDIFEEYEESIDVDLRFAIPGKERQDSVYSGLQEIDVNSELVCIHDSARPLVNTEDVEKVLKDGSAVGAAVLGVPAKATIKEVNSDSLVVKTLDRKTLWEMQTPQVIKPELLKKGFELVKSEGLEVTDDVSIVEYLKHPVYVSQGSYTNIKVTTPDDLLLAERILSEDS
What is the function of this protein?
Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).  Is essential for chloroplast development and required for pigments and gibberellins biosynthesis.
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, AtMECT, AtMEPCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: SYI_CROS5
Sequence: MTDPKSYKDTVNLPKTNFSMRANAVKREPELQKFWADNQIYEKLSQENPEEVFVLHDGPPYANGSLHMGHALNKTLKDIINKYKLLRGYKVRYVPGWDCHGLPIELKVLQSMKSKEREGLTPLKLRHKARDFALKTQEEQAKGFKRFGVWGDWENPYLTLTPEYEAAQIGVFGEMALKGYIYRGLKPVHWSPSSQTALAEAELEYPEGHTSRSIFAAFPIIKASKDTEEILQPFLNKLGVAIWTTTPWTLPGNLAVALNPDLNYAVVEQNSDVCNYQYLIVAADLVERLSTTFETELTVKATLPGKALEHTIYRHPLYDRESEILIGGDYVTTESGTGLVHTAPGHGQEDYMVGQRYGLGILSPVDAKGNFTEEARQFAGLNVLKDANEVIINELKEKGSLLKEEAYQHKYPYDWRTKKPTIFRATEQWFASVKGFRDAALTAIKTVQWIPAQGENRITPMVSDRSDWCISRQRSWGLPIPVFYDEETNEPLLTEETIKHIQTIFAEKGSDAWWEMSIEALLPDQYKADAHKYRKGTDTMDVWFDSGSSWASVAKQRPELKYPADIYLEGSDQHRGWFQSSLLTSVAVNEIAPYKTVLTHGFVLDEKGHKMSKSLGNIVDPNVIINGGKNQKQEPPYGADVLRLWVSSVDYSSDVPIGKTILKQLSDIYRKIRNTARFLLGNLHDFDPKKDTVSYEELPELDRYMLHRITEVFTEVTDAFETYQFFRFFQTVQNFCVVDLSNFYLDIAKDRLYISHPESIRRRSCQTVLAIAIENLAKAIAPVLCHMAEDIWQFLPYETPYKSVFTAGWVKTSKQWENSELSASWAKIRGIRNEVNNALELARKEKAIGSSLDAKVLLYVPEQNLRQQLEKFNPADSLTGNHVDELRYFVLASQVELVDSLDSIKNADYHSESDLVSVGVIKAEGEKCDRCWNYSTKVGEFKDDPTICERCNAALVGDF
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUS3_CANGA
Sequence: MKRELEGSYESERKRGVAQVKAEYVVGAASNVRVDEEEAGSERFVQGEFGGKKNKKKRGQNKNRDNRQQKETHALCPKYVLADVTNQVDLCTFGDNCRFVHDIPTYLEHKRPEITDSVFKTCPVFETLGYCPMGFKCRFLSSHMDKETHKLLGEYPSDLASASHEINHITQDQKYDLIKKRFPFSKSELVLEILDSFQEENREMHREAEKVKEDQQDNEDEQKEKAPQVVQRELEAQKRRQRQKDLYLQYKDTRFFAQEKKPLDLRHKKIVSPLTTVGNLPYRRLMRTLGADVTYSEMALAVPLVQGTNSEWALPKAHESEYPGFGVQVACSKGWQASKAAEALATYIPNGISEINLNSGCPIDLLYRQGSGSALLDNPARMIRCLNAMNYVSGDIPITVKIRTGTKEGHPIADTLVRRLVFETDVAAITLHGRSRQQRYTKVADWDYVSQVAKALRQAEADFMESPQGKESHHDEKTRHTQFVGNGDIFNYTDWYQHLEDPEVDSCMVARGALIKPWIFEEINAQQHLDKTSSERLEILKTYSKFAMDHWGTDEYGIALGRRFFCEFMSFFHRYIPVGILERVPVQLNERPPLWKGRDDMETLLGSSDVKDWIKLSEMFFGPTEDSFVFTPKHKSSSYK
What is the function of this protein?
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.  Specifically modifies U47 in cytoplasmic tRNAs (By similarity).  Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
What are the official names of this protein?
tRNA-dihydrouridine(47) synthase [NAD(P)(+)], mRNA-dihydrouridine synthase DUS3, tRNA-dihydrouridine synthase 3.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HIS4_METHJ
Sequence: MIVFPAVDILGGRCVQLVQGKRETATSYGDPLLCAESWINQGAEALHIVNLDGAFGSSKLNAEKITDVIIRTGVKTQLGGGIRSLDDARSWLDCGVDRIIISTFAADDPECLTILSEEYGSDRIMAGVDARAGEMVTHGWERPAGDFLEWADLFIRKGAGSLLYTNVSVEGLCNGIDPKPIRDLLSTVSVPVVVAGGITSPSDIKILKEADAAGVVLGSALYSGKITLQEALEAAG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AVFA_ASPFN
Sequence: MVTYALLGATGATGSSILRHLLHESPDSLRIQILVRSKVKLLQAFPNLQTTRNPQVHVIQGTSTDPDALSECLRNASIVFMCVAQNGSPIGTTLCQDSARAIISVLQQQQQSQGASYQPCTIVQLRSASLNPALAAQVPAFVHRIVSFCLFANYADIKKACQYYSQAQKQGILEYILVDPPTLHDANGTQPTGYRLISTESQATALSYADLGAAMCEIAHRQSEFHGRAVGVTATGRVRQAWGVLLRHLLEGGSARLREKIAQETVVDGVVFAFLVVLAYLM
What is the function of this protein?
Involved in the conversion of averufin (AVF) to versiconal hemiacetal acetate (VHA) in the aflatoxin biosynthesis pathway.
What are the official names of this protein?
Averufin oxidase A.
What is the protein family that this protein belongs to?
Belongs to the avfA family.
Protein: RISB_HERA2
Sequence: MNVIEGNLIGTGLRVAIVIARWNDFIGGNLLEGAVNTLKRHGVNDDDISVAWCPGSYEIPLVVKKIAERGQHDAIITLGAVIRGATSHYEVVVNAVSSGVTKVMHDTGIPVLLGVLTTDTIEQAIERAGTKAGNKGSECAVAAIEMANLLKQL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: R113A_HUMAN
Sequence: MAEQLSPGKAVDQVCTFLFKKPGRKGAAGRRKRPACDPEPGESGSSSDEGCTVVRPEKKRVTHNPMIQKTRDSGKQKAAYGDLSSEEEEENEPESLGVVYKSTRSAKPVGPEDMGATAVYELDTEKERDAQAIFERSQKIQEELRGKEDDKIYRGINNYQKYMKPKDTSMGNASSGMVRKGPIRAPEHLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKHGWQIERELDEGRYGVYEDENYEVGSDDEEIPFKCFICRQSFQNPVVTKCRHYFCESCALQHFRTTPRCYVCDQQTNGVFNPAKELIAKLEKHRATGEGGASDLPEDPDEDAIPIT
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome (PubMed:29361316, PubMed:29360106).  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).  E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457).  Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457).  Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457).  Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF113A, Cwc24 homolog, RING finger protein 113A, Zinc finger protein 183.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Colocalizes with ASCC2 in nuclear foci after DNA damage by alkylating agents. In the absence of DNA damage, colocalizes with the spliceosome components SNRNP200/BRR2 and PRPF8 in nuclear speckles.
Protein: RL29_BRUC2
Sequence: MKAADVRAKSLDQLNDELGTLKKEQFNLRFQKATGQLEKTARVKQVRRDIARIKTIARQKAAESKA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: PHNC_CHRSD
Sequence: MLELQRLTKTYATGDTALREVSLAVPRGQVVGLIGPSGAGKSTLIRCINRLVAPSGGRILLGDVDLAAVGRAELRRQRRRIGMIFQEYALVERLTVMENVLSGRLGYVPFWRSFTRRFPGRDIENAYRLLDRVGLLAHADKRADALSGGQRQRVGIARALAQEPALLLVDEPTASLDPKTSRQIMRLILEVCEERDLPAIVNIHDVPLAQQFMHRLVGLHAGEVVFDGAPVALDETVLATIYGAEDWASSGREPAPEREPEDTERHLAEVGR
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BEA2_BEABA
Sequence: MPSPEHPSWLSTLLADTRPPPKLFAWSPANLDSPTAVKPDRADRGDFDPGKYPVDAPITTASEPVKRIYIVGPGNVGRLYASYMSRQRDALPITLVVHRKELLSQWVTSEGVVLADRGGKVTKNKQFDVEWWTESRPRYGPVREVADGEKLHNVFISTKADAGLGEADRLRRYLGRCSSVVFAQNGVSKLWAPYGPLYVASRYHADDAPSFSACVVNHGISAAGLFYSIHTSPSDAFIGPIFKGSAAPAHGQNKRRRLDDDFFTTYISSTPFLDTKHVSSGQLWIIQLEKLVLNAAINPLTTLLRCKTGQLFASYDSHDALTRVLDQLLWQASAVIQALINHDANIDMLTSYAETVHRLVPGSDDYGRNFANIRRKLTVRFSQPILKAKLYAFGLNIREHRSSMLQDAEAGRKTEIRDVNGWIVDMAEYLGLDLDVGIHRGLIELIEECVVLDKEELARRLL
What is the function of this protein?
Ketoisovalerate reductase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity (PubMed:18804027, PubMed:19105175, PubMed:27449895).  Ketoisovalerate reductase BEA2 catalyzes the NADPH-specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (PubMed:19105175, PubMed:27449895).  The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the formation of beauvericin via condensation and cyclization of 3 dipeptidol monomers, each composed of one unit of hydroxyisovalerate and one unit of N-methyl-phenylalanine (PubMed:18804027, PubMed:28534477).
What are the official names of this protein?
Ketoisovalerate reductase, KIVR.
What is the protein family that this protein belongs to?
Belongs to the ketopantoate reductase family.
Protein: AROA_CORGL
Sequence: MVFVSDSSISLPIWDAPRARGPIVSDLAIPGSKSITNRALILAALASTPSTIIDVLRSRDTDLMTDGLRSLGITITEEAVDRYRVEPGQLSAGSVECGLAGTVMRFLPPVAAFADGPVHFDGDPQARVRPMTSILDALRSLGVEVDNNNLPFTVNAGEVPEGGVVEIDASGSSQFVSGLLLSAPRFKNGVTVKHVGGRLPSMPHIEMTVDMLRSAGIEIEESENQWVVHPGEILGRTWRIEPDLSNATPFLAAAAVTGGTIKINHWPIKTTQPGDAIRSILERMGCEVELVAQGEGYDLSVTGPVALKGIEIDMSDIGELTPTVAALAALASTESRLTGIAHLRGHETDRLAALTAEINKLGGKCTELKDGLLIEPASLHGGVWHSYADHRMATAGAIIGLAVDGVQVEDIKTTSKTFPGFENVWEEMVG
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_STAA1
Sequence: MGKQCFVTGRKASTGNRRSHALNSTKRRWNANLQKVRILVDGKPKKVWVSARALKSGKVTRV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: PECA_MYCMM
Sequence: MSLLVVAPEWLTSAAAELQSIESALSAANAAAAVPTTGLAAAAADEVSTAVATLFAGFGQEYQAISTQLSAFQQQFALTLNSSAGSYSAAEAQSVSILDTLGQDVFGAINAPTEALLGRPLIGNGANGTATSPNGGAGGLLFGNGGIGYSQTGAGIVGGAGGSAGLIGNGGAGGTGGAGATGGAGGNGGWLFGSGGIGGTGGANALGTGGTGGLGGSAGLFGGGGNGGAGGLGISGDLGTGGAGGTGGFLLGDYGVSGAGGDGRTVPLEVVNVTEPVVNVNVNGGHSTPVLIDTGSAGLVMQVKDVGGPLGLLRMGLPSGISMSAYSGGLTYLFATYPTTVDFGNGIVTSTTGVDVVLFSIPTSPYALTTWLNALWSNPLTTPFDAYFQSAGVDGVLGVGPNAVGPGPSIPTQALGGGLGQGLLIDMKGGELVFGPNPLTPEFSISGAPIATLWVSVNGGAPVAVPSIIDSGGVMGTIPSSVIGGSTLPANTNITVYTDNTMTTEVYHYSTNDYQPTVISSGLMNTGFLPFWNQPVYIDYSPAGTGTTVFDMP
What is the function of this protein?
Aspartic protease that processes the lipase LipY and other PE_PGRS proteins.  Can also cleave itself.  Cleaves LipY both inside the PE domain, before amino acid 98, and after amino acids 136 and 149.  Involved in virulence.
What are the official names of this protein?
PE cleavage protein A, PE-PGRS family protein.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PE family. PGRS subfamily.
What are the subcellular locations of this protein?
Secreted. Cell surface. Note=Secreted via the ESX-5 / type VII secretion system (T7SS).
Protein: YE39_SCHPO
Sequence: MTLIKYKRKNIQFYKKIIANGYAK
What are the official names of this protein?
Uncharacterized protein C20G4.09.
Protein: RPOB_OLEA2
Sequence: MGQLTKKFGKIEVTLPIPHLLNLQVDSYKKFLQEGAAALAPDEGLEGVFRSVFPIEDFNRTASLEYVSYEIGEPKYDQAECISKGLTYEAPIRIKVRLVVYDVDEDSENRTIRDIKEQDIYFGTLPLMTEKGTFIINGTERVIVNQLQRSPGIIFEHDAGKTHSSRKVLYSCRVIPMRGSWLDFDYDHKDILYVRIDRRRKMPATILFKAMGMSRSDILEYFYKKEYYTLEDDGRLMWELDKDLYRKDVAYADVADGEGKVIAKAGKPYTKRSWRLMLEAGIPAVEVAPDYIAGMFLAEDIVDEATGEVLAEAADEITLDLIDRLRECSIKRVPVLHTKGSDTSSSIRDTLLLDKTADQEQARVEIYRRLRPSSPPTPEIASTFFENLFRNPDYYDLSPVGRYKLNQRLGLTTTQERVLTDEDILTAIRVLNHLKDTHGPADDIDHLGNRRVRPVGELVENQYRIGLVRMERAIKERMSLQEVSTLMPHDLINPKPVQAVLKEFFGTSQLSQFMDQTNALSEVTHKRRLSALGPGGLTRERAGFEVRDVHTSHYGRICPIETPEGPNIGLIVSLTTYAKVNDFGFIETPYRVVRDGQVTDEVKYLDASSEHGEVVAQANARLDGDHRFVDEFVTTRVRGDVIMSPREEVTLMDISPSQMVSISAALIPFLEHDDANRALMGSNMQRQAVPLLRSTKPIVGTGMEADVARDSGACIIAEADGVVRYADADRIVVSYEGDLYPRTGGVRSYDLQKYHKSNQSSCFGQKPLVSRGQVIRKGDVLADGPGIEDGELALGKNLVVAFMPWCGYNFEDSILISERCVKEDVFTSVHIEEFEVVARDTKLGPEEITRDIPNVGEDMLRNLDGSGIIRIGANVKPDDILVGKITPKGETQLTPEEKLLRAIFGEKARDVKNTSLKVPPGIEGTVIDVKLFNRRSGEKDERTRNIEDYELARLDQKEKDHIRALTETTREKLAPVVVGKQLAYGLAGQKKGEVIAEAGQTLTAEMLEGLPVKKLSGLFKSKDTNEAVQQALESYDRQIEFINAMYESKREKVTEGDDLPPGVIKMAKVHIAVKRKLNVGDKMAGRHGNKGVVSCILPQEDMPFFADGRPVDIVLNPLGVPSRMNIGQIMETHLGWAAKEMGRKLALMLEHGQDLASVREQVKTVFASDAISSEVDNMDDETFVRSVRRLRDGIVTKTPVFDGATEEQIWSWMEQAGLANDGKTELYDGRTGVRFHNRVTTGVMYILKLHHLVDEKIHARSTGPYSLVTQQPLGGKAQFGGQRLGEMEVWALEAYGAAYLLQEFLTVKSDDVTGRVKMYEKVVKGDNFLEAGLPESFNVLVKELMSLGLDVTLHQEEGKKRTKRAGMTFGDGTSY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.