PharMolix/UniProtQA huggingface dataset:
Protein: PSD2_HUMAN
Sequence: MEEDKLLSAVPEEGDATRDPGPEPEEEPGVRNGMASEGLNSSLCSPGHERRGTPADTEEPTKDPDVAFHGLSLGLSLTNGLALGPDLNILEDSAESRPWRAGVLAEGDNASRSLYPDAEDPQLGLDGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPLTPLIQQRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSLMAMPNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIKVGSDDLERIEARLATLEGDDPSLRKTHSSPALSQGHVTGSKTTKDATGPDT
What are the official names of this protein?
PH and SEC7 domain-containing protein 2, Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C, Exchange factor for ARF6 C, Pleckstrin homology and SEC7 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the PSD family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Cell projection, ruffle membrane. Cleavage furrow. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. In cells undergoing cytokinesis, transiently found around the ingressing cleavage furrow. Not detected at the midbody ring/Flemming body.
Protein: FIS1_SCHPO
Sequence: MTEKHTLRLADPSAIDSIISVDEFLQIKEQYDAEQPLITLQTKFNLAWALVRSDSTQHVQQGLSLFCSIYKDSPERRLECLYYIALSHYKLKQYEESRRYLNMLLSKDPNSPEALKLKNRLYDAVTKEGYIGMVVVAGAVVSVAALVGWASKRLFSKRRP
What is the function of this protein?
Has a role in mitochondrial fission.  Has a role in outer membrane fission but not matrix separation (By similarity).
What are the official names of this protein?
Mitochondrial fission 1 protein.
What is the protein family that this protein belongs to?
Belongs to the FIS1 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: MHPB_RHOSO
Sequence: MPVALCAMSHSPLMGRNDPEQEVIDAVDAAFDHARRFVADFAPDLIVIFAPDHYNGVFYDLLPPFCIGAAAQSVGDYGTEAGPLDVDRDAAYAVARDVLDSGIDVAFSERMHVDHGFAQALQLLVGSITAVPTVPIFINSVAEPLGPVSRVRLLGEAVGRAAAKLDKRVLFVGSGGLSHDPPVPQFATAPEEVRERLIDGRNPSAAERDAREQRVITAGRDFAAGTAAIQPLNPEWDRHLLDVLASGDLEQIDAWTNDWFVEQAGHSSHEVRTWIAAYAAMSAAGKYRVTSTFYREIHEWIAGFGITTAVAVDE
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.  Also catalyzes the cleavage of catechol.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: Y3240_PSEAE
Sequence: MTRYRDVLELHTGHPASDGAGVRLTRVIGGPSPERFDPFLMLDQFDTQNPDDYVAGFPSHPHRGFETVTYMLEGRMRHEDHLGNRGLLKPGGVQWMTAAHGIIHSEMPEQVEGAMRGFQLWVNLPAKNKLAPAGYRDIEPEDVPRLETAGGVKVTVIAGRFDDGQAQQIGAVERPDTEPHYYDLQLPAGGRIAPRLPDGHRVLLYVYEGSLTVEGERPVEIATNRLARLSEEGELSLRSEAGARVLVLAGKPLHEPIVQYGPFVMNSREEIEQALRDYRDGVLAV
What is the function of this protein?
Putative quercetin 2,3-dioxygenase.
What are the official names of this protein?
Putative quercetin 2,3-dioxygenase PA3240, Putative quercetinase, Pirin-like protein PA3240.
What is the protein family that this protein belongs to?
Belongs to the pirin family.
Protein: PYRE_SALNS
Sequence: MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRKEAKDHGEGGSLVGSALQGRVMLVDDVITAGTAIRESMEIIQAHGATLAGVLISLDRQERGRGEISAIQEVERDYGCKVISIITLKDLIAYLEEKPDMAEHLAAVRAYREEFGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: CFI_CANGE
Sequence: MAQAGVSLPKLVIGEVTFPPAAAPPGSSSSLFLAGAGERGLEIDRQFVVFTAIGVYLEDLAVSTLGPKWKGKTADDLAGNSDFFRDIFTGPFEKFTRITMVKPLSGQQYSEKVEENCVAHWKAAGTYTEAEAAAVEKFKEACKNETFPPGTSILFTHQVSPASLTITFWREGSMPETGNTVIESKALSEAILESIIGKHGVSPGAKRSVAQRLSEILEEVKLEGSK
What is the function of this protein?
Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones.  Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin (By similarity).
What are the official names of this protein?
Chalcone--flavanone isomerase, Chalcone isomerase.
What is the protein family that this protein belongs to?
Belongs to the chalcone isomerase family.
Protein: SP5G_BORBZ
Sequence: MDITDIRIKKVDSKNSGSKLLAYVAVTFDNCLVLHNIRVIKGQKGVFIAMPNRRTRVGEYKDIVHPISQDFRKALQTSIFKEYIRENPADLELELDF
What is the function of this protein?
Could be involved in septation.
What are the official names of this protein?
Putative septation protein SpoVG.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: HSP1_MURCY
Sequence: MARYRCCRSRSRCRRRRRRCHRRRRRCSRRRRRRVCCRRYTVIRCRRR
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: LIPA_RHOPB
Sequence: MVVVVDTVSATPIRPRHPEKAARPDSLSPKKPEWIRVRAPTSRGYADTRAIVKENGLVTVCEEAGCPNIGECWDKKHATFMIMGDTCTRACAFCNVKTGMPEALDQAEPEHVAEATFKLGLKHIVITSVDRDDLADGGAAHIAATIRAVRARCPSTTIEILTPDFLRKDGALETVVAAKPDVFNHNLETVPSRYLTVRPGARYFHSIRLLQRVKEIDPTMFTKSGIMVGLGEERHEVLQVMDDLRSADVDFLTIGQYLQPSLKHHAVMRFVTPEEFAGYESVAYSKGFLMVSSSPMTRSSHHAGDNFTKLQAARAALSR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPOL_HBVB6
Sequence: MPLSYQHFRKMLLLDEEAGPLEEELPRLADEGLNRRVAEDLNLGDLNVSIPWTHKVGNFTGLYSSTVPCFNPQWQTPSFPSIHLQEDIVDRCKQFVGPLTVNENRRLKLIMPARFYPNVTKYLPLDKGIKPYYPEYIVDHYFQTRHYLHTLWKAGILYKRESTRSASFCGSPYSWEQDLQHGRLVFQTSKRHGDKSFCPQSPGILPRSSVGPCIQSQLRKSRLGPQPAQGQLAGRQQGGSGSIRARVHPSPWGTVGVEPSGSGPTHNCASSSSSCLHQSAVRKAAYSLLSTSKGHSSSGHAVELHNFPPNSSRFQSQGPVPSCWWLQFRNSEPCSEYCLSHIVNLIEDWGPCTEHGEHRIRTPRTPARVTGGVFLVDKNPHNTTESRLVVDFSQFSRGNTRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSSGLSRYVARLSSHSRINNNQHGTMQNLHNSCSRNLYVSLMLLYKTYGRKLHLYSHPIILGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLEALYAAVTNFLLSLGIHLNPHKTKRWGYSLNFMGYVIGSWGTLPQEHIVQKIKMCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQYLNLYPVARQRPGLCQVFRDATPTGWGLAIGHQRMRGTFVSPLPIHTAELLAACFARSRSGAKLIGTHNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGLYRPLLRLPYQPTTGRTSLYADSPSVPSHLPDRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: TX144_LYCSI
Sequence: MKFVLLFGVLLVTLFSYSSAEMLDDFDQADEDELLSLIEKEEARKDCIPKHHECTSNKHGCCKGHLFKYKCQCTTVVTQSGEETERCFCGTPPHCKAAELVVGFGKKIFG
What are the official names of this protein?
U1-lycotoxin-Ls1bb, Toxin-like structure LSTX-A44.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 03 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS12_RICAE
Sequence: MPTYNQLVRFGRKSKTRKTKSPALESNPFKSGVCLVVKTVTPKKPNSALRKIATVRLSNKRTVNAYIPGEKHSVKEHDRVLVRGGQVPDLPGVKYHIVLGAYDIAGVKGRKQGRSRYGAPRKQVAVTKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: EX7S_BACAH
Sequence: MENKLSFEEAISQLEHLVSKLEQGDVPLEEAISYFKEGMELSKLCDEKLKNVQEQMAVILGEDGELEPFTALGDEA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_CERS5
Sequence: MFNVTKKSIEWGGETLTLETGKVARQADGSVIATLGETSVMANVTFAKAAKPGQDFFPLTVHYQERYYAAGKVPGGFFKREARPSEKETLTSRLIDRPIRPLFVDGFKNEVLLIVTVLSHDLVNEPDIVAMIAASAALTISGVPFMGPIGAARVGYANGEYVLNPDVDDMQKLRENPEQRLDLVIAGTKDAVMMVESEAYELSEAEMLGAVKFGHEAMQPVIDMIIDFAEEAAKEPFDFSPPDYAALYAKVKSLGEAQMRAAFAIREKQERVNAIDAARAAIKAQLSDAELADENLGTAFKKLESSILRGDIINGGARIDGRDTKTVRPIISETSVLPRTHGSALFTRGETQALVVTTLGTGEDEQIIDALHGNSRSNFLLHYNFPPYSVGEVGRFGPPGRREIGHGKLAWRALQAVLPAATDFPYTIRVVSEITESNGSSSMASVCGGSLSMMDAGVPLKAPVAGVAMGLILEDDGKWAVLTDILGDEDHLGDMDFKVAGTENGITSLQMDIKVAGITPAIMEQALAQAKDGRMHILGEMSKALSSANSFSAYAPKIETLTIPTDKIREVIGSGGKVIREIVETSGAKVDINDDGVIKIASNDQAAIKKAYDMIWSIVAEPEEGQIYTGKVVKLVDFGAFVNFFGKRDGLVHVSQIANKRLTHPNEVLKEGQEVKVKLLGFDERGKVRLGMKMVDQETGQEIAPEKKEEATEA
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_COXB1
Sequence: MGQKVNPVGMRIGITRDWTSNWYADKKDFADRLNEDLNVRQLLQKRLKGAAVSRIQIERPARNAKIIIHSARPGVIIGKKGGEIEALRDEISKVMKVPVHITIEEVRKPELDAKLVAENIAQQLERRVMFRRAMKRAVQNTLRQGALGVKISVSGRLGGAEIARTEWYREGRVPLHTFRADIDYATASAKTTYGIIGVKVWIFKGEVHAPKPQAEEAAPQETEEEVK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: ESF2_KLULA
Sequence: MSKEYSDVDDFASDEEEDNQVLITGKDAKKNVIQFDQEEDEEEQEEEDEEVQDEEEPEDKVVQLTEQQIEKEKQRRLKKLKSDKKTKHKTGVVYLSRVPPYMKPAKLRQILTRFGEVDRLFLKREEEHKHQQRVKSGGNKKTMFEEGWAEFIRKKDAKLCASTLNGNIIGGKKGNFYHDDVMNVKYLPGFKWADLTEQIARENDIRQAKLQLEISQANKLNAEFIHNVEKSKMVNKMKQSKKRNQQESQQVDEEVRRTFKQRKVASTRASAPDSQRQSQPQSKALNDVMHSLF
What is the function of this protein?
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis.  Required for the early cleavages at sites A0, A1 and A2 (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein ESF2, 18S rRNA factor 2.
What is the protein family that this protein belongs to?
Belongs to the ESF2/ABP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HTPX_ECOLU
Sequence: MMRIALFLLTNLAVMVVFGLVLSLTGIQSSSVQGLMIMALLFGFGGSFVSLLMSKWMALRSVGGEVIEQPRNERERWLVNTVATQARQAGIAMPQVAIYHAPDINAFATGARRDASLVAVSTGLLQNMSPDEAEAVIAHEISHIANGDMVTMTLIQGVVNTFVIFISRILAQLAAGFMGGNRDEGEESNGNPLIYFAVATVLELVFGILASIITMWFSRHREFHADAGSAKLVGREKMIAALQRLKTSYEPQEATSMMAFCINGKSKSLSELFMTHPPLDKRIEALRTGEYLK
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROK_STAA9
Sequence: MNHDKSPIILIGFMGTGKSTIGKYVADEQNLSFIDIDSYIEEKYKLTIPEIFSKHGEQYFRNLEFTCLQECINTADIIATGGGIIESEEAFNFLKNQKNIIWLDCNIDIIYSRINDDPHRPNANNKTIKQLNDLYCSRILRYNEIAFKKFDSHLLSISEIYYELLNLIKASDQY
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_SALAR
Sequence: MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVGQIKTRLGANPVPLQLAIGAEEGFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMQDLADEWHQNLIESAAEASEELMEKYLGGEELTEEEIKQALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKTARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPENPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVEANVGKPQVAYREAIRAKVTDIEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKSGPLAGYPVVDLGVRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDDAPNNVAQAVIEARGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCNBA_HUMAN
Sequence: MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQPRPQLDLKASRKLPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLINLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMKVTKGDQGDQNDLENGPHSPLQTLCNGDLSSFGVAKGKVHCD
What is the function of this protein?
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient.  It is a tetrodotoxin-resistant sodium channel isoform.  Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
What are the official names of this protein?
Sodium channel protein type 11 subunit alpha, Peripheral nerve sodium channel 5, PN5, Sensory neuron sodium channel 2, Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.9, hNaN.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THIOG_SYNY3
Sequence: MQTTSDVLIIGGGIIGLAIAVELKLKQKRLQVTVLSRDFAQAASHAAAGMLAPHAEQIAPGPMLDLCLASRWRYGEWVEKLEQLTGMETGYNPCGILSPVFEAPHGNSSTNSAWLDQETIRYYQPGLGEDVIGGWWHPDDGQVDNRKLVSALRQAAQSLGVQIQEGVTVQAIAQRHGQVTAVLTDQGSFQADSYVLANGSWAKELLPLPVFPVKGQMMALRMPAGTHQPYPLQRVLFGPQTYLVPRRDGRLIVGATSEQVDWQPHNTPQGIQTLLGRAIRLFPALGDWAIEDFWWGFRPGTPDEQPFLGYGPCDNLILAIGHYRNGILLAPITAALISDLILDQKVSPLIHAFSPQRFLTTTNPPVLSCRPMTAVFPSIANPSLPHAAENSEGSKDLLEIAGRKFHSRLMTGTGKYPSLTTMQESVASSGCQIVTVAVRRVQTNAPGHEGLAEAIDWSTIWMLPNTAGCQTAEEAIRVARLGREMAKLLGQEDNNFIKLEVIPDTQYLLPDPIGTLEAAEQLVKEGFAVLPYINADPLLAKRLEEVGCATVMPLGSPIGSGQGIRNAANIGIIIENAKVPVVVDAGIGTPSEAAQAMEMGADAVLINSAIAMAANPVAMAQAMGMATQAGRLAYLSGRMPIKAKANASSPLTGLVG
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Bifunctional protein ThiO/ThiG.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG2_SHESM
Sequence: MTELSKYRNIGIFAHVDAGKTTTTERILKLTGRIHKAGETHDGESTTDFMVQEAERGITIQSAAVSCFWKDHRFNVIDTPGHVDFTVEVYRSLKVLDGGIAVFCGSGGVEPQSETNWRYANESEVARIIFVNKLDRMGADFLRVVKQTKDVLAATPLVMVLPIGIEDEFKGVVDLLTRQAYVWDETGLPENYSIQEIPADMVDLVEEYREQLIETAVEQDDDLMEAYMEGEEPSIEDLKRCIRKGTRTMAFFPTFCGSAFKNKGMQLVLDAVVDYLPAPNEVDPQPLTDEEGNETGEYAIVSADESLKALAFKIMDDRFGALTFVRIYSGRLKKGDTILNSATGKTERIGRMCEMLANDRIEIESAEAGDIIAIVGMKNVQTGHTLCDVKYPCTLEAMVFPEPVISIAVAPKDKGGSEKMAIAIGKMIAEDPSFRVETDEDSGETILKGMGELHLDIKVDILKRTYGVELIVGEPQVAYRETITQMVEDQYTHKKQSGGSGQFGKIEYIIRPGEPNSGFVFKSSVVGGNVPKEYWPAVEKGFASMMNTGTIAGFPVLDVEFELTDGAYHAVDSSAIAFEIAAKAAFRQSIAKAKPQLLEPIMKVDVFSPDDNVGDVIGDLNRRRGMIKDQVAGVTGVRVKADVPLSEMFGYIGTLRTMTSGRGQFSMEFSHYSPCPNSVADKVVEQVKERKAAEAKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 2, EF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_PAVCN
Sequence: MAPPAKRARRGLVPPGYKYLGPGNSLDQGEPTNPSDAAAKEHDEAYAAYLRSGKNPYLYFSPADQRFIDQTKDAKDWGGKIGHYFFRAKKAIAPVLTDTPDHPSTSRPTKPTKRSKPPPHIFINLAKKKKAGAGQVKRDNLAPMSDGAVQPDGGQPAVRNERATGSGNGSGGGGGGGSGGVGISTGTFNNQTEFKFLENGWVEITANSSRLVHLNMPESENYRRVVVNNMDKTAVNGNMALDDIHAQIVTPWSLVDANAWGVWFNPGDWQLIVNTMSELHLVSFEQEIFNVVLKTVSESATQPPTKVYNNDLTASLMVALDSNNTMPFTPAAMRSETLGFYPWKPTIPTPWRYYFQWDRTLIPSHTGTSGTPTNIYHGTDPDDVQFYTIENSVPVHLLRTGDEFATGTFFFDCKPCRLTHTWQTNRALGLPPFLNSLPQSEGATNFGDIGVQQDKRRGVTQMGNTNYITEATIMRPAEVGYSAPYYSFEASTQGPFKTPIAAGRGGAQTYENQAADGDPRYAFGRQHGQKTTTTGETPERFTYIAHQDTGRYPEGDWIQNINFNLPVTNDNVLLPTDPIGGKTGINYTNIFNTYGPLTALNNVPPVYPNGQIWDKEFDTDLKPRLHVNAPFVCQNNCPGQLFVKVAPNLTNEYDPDASANMSRIVTYSDFWWKGKLVFKAKLRASHTWNPIQQMSINVDNQFNYVPSNIGGMKIVYEKSQLAPRKLY
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1.  The capsid encapsulates the genomic ssDNA.  Capsid proteins are responsible for the attachment to host cell receptor TFRC.  This attachment induces virion internalization predominantly through clathrin-endocytosis.  Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s).  VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell.  Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein.  Exposure of nuclear localization signal probably allows nuclear import of capsids (By similarity).
What are the official names of this protein?
Capsid protein VP1, Coat protein VP1.
What is the protein family that this protein belongs to?
Belongs to the parvoviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.