PharMolix/UniProtQA huggingface dataset:
Protein: ABCC8_HUMAN
Sequence: MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVRADK
What is the function of this protein?
Subunit of the beta-cell ATP-sensitive potassium channel (KATP).  Regulator of ATP-sensitive K(+) channels and insulin release.
What are the official names of this protein?
ATP-binding cassette sub-family C member 8, Sulfonylurea receptor 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AMPN_STRLI
Sequence: MPGTNLTREEARQRATLLTVDSYEIDLDLTGAQEGGTYRSVTTVRFDVAEGGGESFIDLVAPTVHEVTLNGDALDTAEVFQDSRIALPGLLPGRNILRVVADCAYTNTGEGLHRFVDPVDDQAYLYTQFEVPDARRVFASFEQPDLKATFQFTVKAPEGWTVISNSPTPEPKDNVWEFEPTPRISSYVTALIVGPYHSVHSVYEKDGQSVPLGIYCRPSLAEHLDADAIFEVTRQGFDWFQEKFDYAYPFKKYDQLFVPEFNAGAMENAGAVTIRDQYVFRSKVTDAAYEVRAATILHELAHMWFGDLVTMEWWNDLWLNESFATYAEAACQAAAPGSKWPHSWTTFANQMKTWAYRQDQLPSTHPIMADISDLDDVLVNFDGITYAKGASVLKQLVAYVGEEAFFKGVQAYFKRHAFGNTRLSDLLGALEETSGRDLKTWSKAWLETAGINVLRPEIETDADGVITSFAIRQEAPALPAGAKGEPTLRPHRIAIGAYDLDGAGKLVRGDRVELDVDGELTAVPQLVGKARPAVLLLNDDDLSYAKVRLDEQSLAVVTEHLGDFTESLPRALCWASAWDMTRDAELATRDYLALVLSGIGKESDIGVVQSLHRQVKLAIDQYAAPTAREALLTRWTEATLAHLRAAEAGSDHQLAWARAFAATARTPEQLDLLDALLDGTQTIEGLAVDTELRWAFVQRLAAVGRFGGSEIAAEYERDKTAAGERHAATARAARPTEAAKAEAWESVVESDKLPNAVQEAVIAGFVQTDQRELLAAYTERYFEALKDVWASRSHEMAQQIAVGLYPAVQVSQDTLDRTDAWLASAEPNAALRRLVSESRSGIERALRAQAADAAAAE
What is the function of this protein?
Aminopeptidase with broad substrate specificity to several peptides.  Shows strong preference for leucine but cleaves also next to Arg and lysine in peptide-bond-containing substrates.
What are the official names of this protein?
Aminopeptidase N, Alanine aminopeptidase, Lysyl aminopeptidase, Lys-AP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1647_STRPD
Sequence: MMNMQNMMKQAQKLQKQMEQKQADLAAMQFTGKSAQDLVTATFTGDKKLVGIDFKEAVVDPEDVETLQDMTTQAINDALTQIDEATKKTLGAFAGKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein MGAS10270_Spy1647.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MSRP_RHIE6
Sequence: MPSYRPPKIASSEITPRRIYMRRREFLGAAALGAVALYGAGKASAAALPAVESKYKLDEKPTPLKDVTTYNNFYEFGLDKGDPAANSGAFKPLPWTVKVDGMVNKPGTFDLEALMKEFPIEERTYRMRCVEAWSMVIPWDGFPLASLLDKVEPLGSAKYVAFETIVRPEEMPGQKGFFQSLDWPYVEGLRLDEARHPLTLLAVGLYGETLANQNGAPIRLVVPWKYGFKGIKSIVRITLTDQQPKNTWQVTNPQEYGFYANVNPAVDHPRWSQASERRIGEGGFFGASRHPTLPFNGYADEVASLYAGMDLKANF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: Y1377_ALIF1
Sequence: MDQGLSLNTLPLKELRNLIRNNQFTGSTTGCAAGYLQANLVILPAEWATDFLLFCQKNPVACPLIDVTQPGEKYLQSIGRDIDLSTDVPEYHVFYDGEFETAVSDLSTLWREDLVTFVLGCSFSFEEALIQSGLSIRNIDEGKNVSMYDTSIPCQSSGKFSGNYVVSMRPFTSIDAIRAIQITTRFPKAHGAPVHFGDPSLIGINDISTPNYGDAVEIKPNEVPVFWGCGVTPQNVIRQSRPPFCITHAPGKMLITDRLSSEFAVL
What are the official names of this protein?
Putative hydro-lyase VF_1377.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: ASTD_SHEPA
Sequence: MTQFIEGKWVEGLGHEVTSINPANQKVIWNSKTATPEQVGVAVDAARNAQFDWFMLGFDARLAIVEAYRDQLEANKAEMAEVIAQETGKPQWETATEAGAMIGKIGLSVAAYHKRTGTSENDTPAGRAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPKVAELMLKLWEKAGLPKGVINLVQGEVETGKALAAHPQIDGLFFTGSSRTGHILHQQYAGDPGKILALEMGGNNPLIIKDVADTKAAVHDIIQSAYISAGQRCTCARRLYVEKGAAGDALLEQLVAAVKQIQVGPWNAQPQPFMGSMISETAAKGMVEAQRNLVNLGGNALVELTHLEVGTGLVSPGLIDVTGVIELPDEEYFGPLLQVVRYSDFDEAIKLANATRYGLSAGILADSREDYDYFLARIRAGIVNWNKQITGASGAAPFGGVGASGNHRASAFYAADYCAYPVASVEADAVSLPATLSPGLSI
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: FACR2_ARATH
Sequence: MEALFLSSSSSSIVASNKLTRLHNHCVWSTVIRDKKRFGPTWCRVGGGGDGGRNSNAERPIRVSSLLKDRGQVLIREQSSPAMDAETLVLSPNGNGRTIEINGVKTLMPFSGASMVGMKEGLGIISFLQGKKFLITGSTGFLAKVLIEKVLRMAPDVSKIYLLIKAKSKEAAIERLKNEVLDAELFNTLKETHGASYMSFMLTKLIPVTGNICDSNIGLQADSAEEIAKEVDVIINSAANTTFNERYDVALDINTRGPGNLMGFAKKCKKLKLFLQVSTAYVNGQRQGRIMEKPFSMGDCIATENFLEGNRKALDVDREMKLALEAARKGTQNQDEAQKMKDLGLERARSYGWQDTYVFTKAMGEMMINSTRGDVPVVIIRPSVIESTYKDPFPGWMEGNRMMDPIVLCYGKGQLTGFLVDPKGVLDVVPADMVVNATLAAIAKHGMAMSDPEPEINVYQIASSAINPLVFEDLAELLYNHYKTSPCMDSKGDPIMVRLMKLFNSVDDFSDHLWRDAQERSGLMSGMSSVDSKMMQKLKFICKKSVEQAKHLATIYEPYTFYGGRFDNSNTQRLMENMSEDEKREFGFDVGSINWTDYITNVHIPGLRRHVLKGRA
What is the function of this protein?
Catalyzes the reduction of fatty acyl-CoA and -ACP (acyl carrier protein) substrates to fatty alcohols (PubMed:19062129, PubMed:27274541).  Triggers the accumulation of C16 and C18 fatty alcohols; converts palmitoyl-acyl carrier protein to the corresponding C16:0 alcohol with NAD(P)H as electron donor, but seems inactive toward palmitoyl- or other acyl-coenzyme A (PubMed:21813653).  Triggers also the formation of some C16:0 aldehydes (PubMed:27274541).  Involved in the synthesis of the lipid component in sporopollenin (PubMed:19062129).  Required for exine patterning of pollen grain by mediating the formation of pollen wall substances (PubMed:9351246, PubMed:21813653, PubMed:21849515).
What are the official names of this protein?
Fatty acyl-CoA reductase 2, chloroplastic, AtFAR2, Fatty acid reductase 2, Male sterility protein 2.
What is the protein family that this protein belongs to?
Belongs to the fatty acyl-CoA reductase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EZRI_BOVIN
Sequence: MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKKVSAQEVRKESPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKELHKAGYLGSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTRKAEKELSDQIQRALKLEEERKRAQEEAGRLEADRLAALRAKEELERQAADQIKSQEQLATELAEYTAKIALLEEARRRKENEVEEWQLRAKEAQDDLVKTREELHLVMTAPPPPPVYEPVNYHVHEGPQEEGTELSAELSSEGILDDRNEEKRITEAEKNERVQRQLMTLTSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAM
What is the function of this protein?
Probably involved in connections of major cytoskeletal structures to the plasma membrane.  In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole.  Along with PLEKHG6, required for normal macropinocytosis (By similarity).
What are the official names of this protein?
Ezrin, Cytovillin, Villin-2, p81.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Microvillar peripheral membrane protein (cytoplasmic side). Localizes to cell extensions and peripheral processes of astrocytes (By similarity).
Protein: RL10_HALOH
Sequence: MPRPEKEAVVNELTDKLSSAKSLVLTDYKGLDVATITELRAKLREAGVEYRVVKNTLARIAAKKAEIEEINEVLVGPTAIAFGIEDAVSPAKVLVDFAKEHEELEIKGGVLNGEVIDDEKIKSLAKIPPREELLAKAFAGMKAPLTGFVNVLQGNIRNLVNVLNQIKDQKDE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ASNA_ECO5E
Sequence: MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLQLEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_VARPS
Sequence: MRGYEVIIGFETHAQLSTASKIFSRASTAFGAEPNTQACAVDLALPGTLPVMNKGAVERAIKLGLALGSHIAPRSVFARKNYFYPDLPKGYQISQYEIPVVQGGAVSFFLGEEKKTVRLVRAHLEEDAGKSLHENFIGQSGIDLNRAGTPLLEIVTEPDMRSTAEAVAYARELHKIVTWIGICDGNMQEGSFRCDANVSVRKPGEKLGTRREIKNLNSFKFMQQAIDYEINSQINELEDGRKIEQATVLFDPDTGETRTMRTKEDAADYRYFPDPDLPPLAIEAEWIERVRATMPELPRAMAERYVRDHGMSEYDAAQLTQSPALARYFDDAVKAGATPKLASNWITGEMARRLNAQEIGIEAAPVTAQQLAQLVGRIADGTLPNNAARQVFDALWTGEGSDVDAIIEARDLKPMSDTGALDRILDEVIAKNAKNVEEYRGGKEKALNGLVGQVMKASGGKANPAQVTELLKAKLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: CQ10X_DANRE
Sequence: MAEKATSLFLRAMEISEKQSFDVMRRNSSCTIRHLSSCGILETRRVSLPPPPSASSQMVPSRSFINLTAPLIMRRMEYSESRSINYSPEQMYDVVANVEQYQQFVPWCKKSKVTRGRNGDMRAQLEIGFPPIVERYTSEVTVIPNHQVRAVCTDGSLFNHLETLWRFTPGAAGQSCNVEFFVTFEFKSLLHSQLATMFFDEVVKQMVNAFETRAKKLYGTGVHRQQASLRRAI
What is the function of this protein?
Required for the function of coenzyme Q in the respiratory chain.  May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
What are the official names of this protein?
Coenzyme Q-binding protein COQ10 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COQ10 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: QDR1_CANAL
Sequence: MPGNREEFDIEKVLKSKKLEAIETSTEKKAPYTVFESTDKLLLIIVLSLVGFWSAISSPIYFPALPTLTKYFNTTPSVMNISVVAYLIFQGIAPTISSNLADTFGRRPVILGSIIVFCAVCIAISQTNVYWLLALLRCFQAAGIAPVFAISSGVAGDICTPANRGGMVGAVSGLQLAGNGIGGLVGAALISGFHTWRAIFIFLAIGGGVTFIFAFLVLAETSRRIVGNGSIRPKNVLNKAVLIYLPHFKNKITNDYSTLQPKGPFDILGPFKIFFQKEVFCTLLPSGMHFAAWTVSLTSLSTELESAKYNYSVMKVGLVYLPQGIACFIGSLIAGRCLNWYYRYRKNLYDKQMNDVPLNDRPPFNLVASRLTLTIVPLAMMVIGLSAFGWCLEYKKPIISIIISTILISFSASVMMSICTTMLVDLYPKQSGASASCVNLMRCWLAALFTGVLDKIISALGLGGTYTLLTGICLLTDLGLVYVLYTANQRFVNYVSPNQTAVNSDAEDY
What is the function of this protein?
MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence.  No substrate for transport has been identified yet, but plays an important role in the growth in the host.
What are the official names of this protein?
MFS antiporter QDR1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. CAR1 family.
Protein: PPK5_GROGR
Sequence: FGETSGETKGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, FXPRL-amide, GroGr-Capa-PK.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMB_CRYNJ
Sequence: MEAGPSTASPGVSVSPAPALTAGEVQLLKVPQKRFYRQRAHANVFIDHELDYPKRPELMDWSTHYPAYFSQPNEDGTITQGEKKVEWADVGCGFGGLLMALAPLFPEKLMLGMEIRTSVTKYVTDRIAATRQAQSLLPADSVDTKPGGYQNVSVIKANSMKHMPNFFAKGQLEKIFFLFPDPHFKNRKHKARIITPALLAEYAYVLRPGGILYTVTDVKDLHEWMAHHLHAHPLFEYIPTETLSDDPILEAARTATEEGQKVERNKGDKWVACFRRKEDPKEEDED
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SV2A_HUMAN
Sequence: MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
What is the function of this protein?
(Microbial infection) Receptor for the C. botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119).  Probably also serves as a receptor for the closely related C. botulinum neurotoxin type A1.
What are the official names of this protein?
Synaptic vesicle glycoprotein 2A.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Presynapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals.
Protein: GLRX2_VARV
Sequence: MKNVLIIFGKPYCSICENVSEAVEELKSEYDILHVDILSFFLKDGDSSMLGDVKRGTLIGNFAAHLSNYIVSIFKYNPQTKQMAFVDINKSLDFTKTDKSLVNLEILKSEIEKANYGVWPPVTE
What is the function of this protein?
Glutaredoxin necessary for virion morphogenesis and virus replication.  Functions as a thiol-disulfide transfer protein between membrane-associated OPG128 and substrates OPG095 or OPG053.  The complete pathway for formation of disulfide bonds in intracellular virion membrane proteins sequentially involves oxidation of OPG072, OPG128 and OPG088.  Exhibit thioltransferase and dehydroascorbate reductase activities in vitro.
What are the official names of this protein?
Glutaredoxin-2.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: PHNG_RHIME
Sequence: MMDAAKTSDDAGVAQRREGMRLLARATLGELSLAWDAIDDKPEVAPVRGPETGLVMVRGKIGGGGDPFNLGEATVSRATVRLSTGEVGHGQLLGTDKARARLAAIFDALFQSAAHRASVEALHEQVAARLDAEDRRKAEETAATRVDFFTMVRGED
What is the function of this protein?
Together with PhnH, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.
What are the official names of this protein?
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, RPnTP synthase subunit PhnG.
What is the protein family that this protein belongs to?
Belongs to the PhnG family.
Protein: SMC5_CHICK
Sequence: MAVQTRLRAEGSQLRLCDTHHAGKPRSVEGSIVRIYMENFLTYDICEVRPGPNLNMIIGANGTGKSSIVCAICLGLAGKPSFLGRAEKVGLFVKQGCLKGLVEIELFKVPENIIITREIQVVTNTSTWHINRKLTTLKTVEEQVAALNIQVDNLCQFLPQDKVGEFARMSKIELLEATEKSIGPPEMYQFHCKLKSLKEKERELENVCKDKVNSLEKMKQRAERYKQDVDRYHECKRHLDLIDMLQRKRPWVEYETVRQQHEDVKQRRDQAKEELKNLKEMQSPLTKKIRECEEFYNSLNMKIKNTADEIKGVSQKCKEKQDALEMKDKQISEINQALRMKKDEEVDRKKKILSAYKMIDEWNNELNTVTDCENLQPQIDAVNNELKHVQEERANIDSDIGDVTTEKINQERENGRIIDRIGQLNNIIKVKEETLQARFRDTHSALMWLRKNKHKFKKEVCEPMMLTINVKDNKHAKYVENHISTNDMKAFVFESQEDMELFLVELRDRQKLRVNAVCAPDKSCAETLPSTPIEELHRYGFFSYLRELFDAPLPVMSYLCSQYHVHEVPVGTEKTRNMIERVIKETKLKQIYTAEEKYTIKVSTYTKLSFSTNMCLRPAQFLNYYVDTDERRQLENQQQNIKHILQSLDKQLMTLCERQKHLECRDNELRQQKKELLERGSRRKQLESKIAVKYDSIRQLEQNPINLEKESQQAKVKIRAINIQKAKLVTELMCHIKNYVSLNICKADLILQSTAVDAEKNRLEAEYKAASVELRASEQRFLELDERKRILTENCKELLKKARQMCNMNLDQHLPKEFQTAFQTLPDTLEEIDAFLNEERSRVSCFTGLSASVVEECSKQMEEIQKLMESIEENKKELDDYKQSISKIKERWLNPLKKMIESINEKFSGFFSSMESVGEVDLHVENEEEYDKYGIRIRVKFHNFTDLHELTPYHQSGGEKSVSTVLYLMALQELNRCPFRVVDEINQGMDPVNERRVFEMFVKTACKESTSQYFLITPKLLQNLTYNEKMTLLFVYNGPFMLEANKWNLKSFCRRRRRLGRMDEQ
What is the function of this protein?
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination.  The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.  The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.  Required for recruitment of telomeres to PML nuclear bodies.  Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity).
What are the official names of this protein?
Structural maintenance of chromosomes protein 5, SMC protein 5, SMC-5.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC5 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin.
Protein: CERS3_MOUSE
Sequence: MFQTFRKWFWSERYWLPPTIKWSDLEDHDGLVFVKASHLYITIPYAFLLMVVRYFFEKFVATPLANALGIKKTQHKIKPNAILENFFKHSTSKPSHTDIYGLAKKCNLTERQVERWLRIRQKQNKPCRLQKFQESCWRFTFYLLITMAGAVFLYDKPWAYDLWEVWNDYPRQPLLPSQYWYYILEMSFYWSLVFSLSTDIKRKDFLAHVIHHLAAISLMSFSWCANYIRSGTLVMFIHDISDIWLESAKMFSYAGWKQTCNTLFFIFTVVFFISRFIIFPFWILYCTLILPLHYLEPFFSYIFLNLQLMILQGLHVYWGYFILKMLNRCIFTQNVQDVRSDNEEEEEEEEEEEAESTKGKETEYLKNGLGTNRHLIANGQHGR
What is the function of this protein?
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) (PubMed:16753040, PubMed:18541923, PubMed:22038835).  N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:16753040, PubMed:18541923, PubMed:22038835).  It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:22038835).
What are the official names of this protein?
Ceramide synthase 3, CerS3, mCerS3, Dihydroceramide synthase 3, LAG1 longevity assurance homolog 3, Sphingosine N-acyltransferase CERS3, Ultra-long-chain ceramide synthase CERS3, Very-long-chain ceramide synthase CERS3.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GL_EBVA8
Sequence: MRTVGVFLATCLVTIFVLPTWGNWAYPCCHVTQLRAQHLLALENISDIYLVSNQTCDGFSLASLNSPKNGSNQLVISRCANGLNVVSFFISILKRSSSALTGHLRELLTTLETLYGSFSVEDLFGANLNRYAWHRGG
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Acts as a functional inhibitor of gH and maintains gH in an inhibited form.  Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.  The heterodimer gH/gL targets also host EPHA2 to promote viral entry.
What are the official names of this protein?
Envelope glycoprotein L, gL.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein L family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans- Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans- Golgi where secondary envelopment occurs.
Protein: DAPB_LISMH
Sequence: MRVAVSGFKGRMGHEVVKTVLREADLELVAVLDHEPKEKNINEIVEFSSLDVPVFGNLSEMLEEIKPDCVVDFTTPKVGYSNTKTILEHGVRAVVGTTGFTPEQISELRSIAESKKIGALIAPNFAVGAVLMMQFAQKAAKYFPNVEIIELHHDNKLDAPSGTAVKTAEMMAETREFVKQGAADEVELIEGARGSEYEGMRIHSVRLPGLVAHQEVIFGAEGQGLTIRHDSYDRISFMSGVALSVRKTKELETLIYGLENILD
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.