PharMolix/UniProtQA huggingface dataset:
Protein: CD34_CANLF
Sequence: MLAGRGARAGGGLPRGWTALCLLSLLPFGFTNTETVITPTTVPTSTEIMSAVSENTSKREAITLTPSGTTTLYSVSQDSSGTTATISETTVHVTSTSEITLTPGTMNSSVQSQTSLAITVSFTPTNFSTSSVTLEPSLLPGNGSDPPYNSTSLVTSPTEYYTSLSPTPSRNDTPSTIKGEIKCSGVKEVKLNQGICLELNETSSCEDFKKDNEEKLTQVLCEKEPAEAGAGVCSLLLAQSEVRPHCLLLVLANKTELFSKLQLLRKHQSDLKKLGIRDFTEQDVGSHQSYSRKTLIALVTSGILLAVLGTTGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGVSPEAQGKASVNRGPQENGTGQATSRNGHSARQHMVADTEL
What is the function of this protein?
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells.  Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components.  Presents carbohydrate ligands to selectins (By similarity).
What are the official names of this protein?
Hematopoietic progenitor cell antigen CD34.
What is the protein family that this protein belongs to?
Belongs to the CD34 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TSR4_SCHPO
Sequence: MSQKWVQTQAWLGFPDVPISQEDKPDEYSTFLGGFPVFFDGCSLNPNIIKCGNCKNLCRLLLQCYAPLEGDNLKERALYVWGCHNPSCRRVPNSIVCVRGVRLPLKSDIEAVKSPKAISHLEEKKSSPKEKKVNPFAITSESSRGLNPFSDATSANNPFSLSTDVNPSKPSSNVFSKPSFAAKAQQSITDQQKTQAKTKTKHIALTTSGMSVHPPVTETYTYPVTEAFQGMFLGLDLEYVPQNKVNSKKDDFSTFKNYTPYLNDSSEAWEKESYEKSPSVYEKTFRLFSEKISHNPTQCLRYERGGTPLLASGRDKLGQQLKSVTNFGKSPVPLCPLCKSPRLFEMQLMPHAISILNDEIAEWSTILVATCSMDCNPPINKDRVGYAVEWVGIQWD
What is the function of this protein?
Required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA.
What are the official names of this protein?
Probable 20S rRNA accumulation protein 4.
What is the protein family that this protein belongs to?
Belongs to the TSR4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: 3MGH_RHILO
Sequence: MGRAHTVSRGEDHPPIARSELPDDTAALARYLIGKLVVRDLPEGMVSGRIVETEAYVVGDAAGHGFRGMTPRNRSLFLERGHAYVYLAYGVSMMLNVSSEVPGIGTGVLIRALEPLDGIEIMRRNRGVERLRDLARGPGRLAAALRIDRSLDGLDLCRKGPLWLAKDNQKPGEIGQSTRIGITKDAARLLRFYVRGSLFVSGPRSLQE
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: RS19_RHOPA
Sequence: MVRSVWKGPFVEASLLKKADAARASGRHDVIKIWSRRSTILPQFVGLTFGVYNGQKHVPVSVNEEMVGHKFGEFSPTRTFHGHAGDKKSKKG
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, RRP-S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: COLQ_HUMAN
Sequence: MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT
What is the function of this protein?
Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
What are the official names of this protein?
Acetylcholinesterase collagenic tail peptide, AChE Q subunit, Acetylcholinesterase-associated collagen.
What is the protein family that this protein belongs to?
Belongs to the COLQ family.
What are the subcellular locations of this protein?
Synapse.
Protein: THIO1_NOSSO
Sequence: MSAAAQVTDSTFKQEVLDSDVPVLVDFWAPWCGPCRMVAPVVDEIAQQYEGKIKVVKVNTDENPQVASQYGIRSIPTLMIFKGGQKVDMVVGAVPKTTLSQTLEKHL
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin 1, Trx-1, Thioredoxin-M.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: DEOD_BUCA5
Sequence: MSTPHINSKKDDFSDIVLMPGDPVRAKYIAEKYLSNFVQVNNTRLMLAYTGFYKNRKISIMSHGIGIPSASLYTRELIIEFNVKKIIRIGTCGAVRDDIKLRDIVISMGASTDSKVNRIRFNDHDFAAIADFDMIYNIVSISKKMKIKVSIGNFFTTDSFYNDDKKMLNILKKYNIIGVDMETAGIYGVASELKVQALSICTVSDHITNKEFLSSKERESSFNDMIELALESVL
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: PYRDA_STRPN
Sequence: MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVTKTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDYYLDYLLDLQEKESNRTFFLSLVGMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTKPLGIKLPPYFDIVHFDQAAAIFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGIGGEYIKPTALANVHAFYQRLNPQIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVSAFDRITNELKAIMVEKGYESLEDFRGKLRYID
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
What are the official names of this protein?
Probable dihydroorotate dehydrogenase A (fumarate), DHOD A, DHODase A, DHOdehase A.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFL_COTJA
Sequence: MSSYGYDPFFPSYKRRYADSPRLHVSAMRSGGYSSARSAYSSLSAPVSSVSVRRSYATSSASGSLLHSVDSLDLSQVAAISNDLKSIRSQERAQLQDLNDRFACFIERVHELEQQNKVLEAELLVLRQKHAEPSRFRALYEQEIRELRLAAEEATSEKQALQGERESLEETLRGLQARYEEEVLSREDAEARLLEVRKGADEAGLARAELEKRVDSLLDELAFLKKVHEEELAELQAQIQYAHLSVEMDVSAKPDLSAALRDIRAQYEKLAARNMQNAEEWFRSRFTVLSESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEATRGMNEALEKQLQELEEKQSADISALQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYTQTAPTFGRSAYSGLQSTSYLMTTRSFPTYYSSHVQEEQIEIEETIEAAKAGEAKAAPAEEGEEEEKEEGEEEEAGGEEAEEEEEGAKEESEEGKEGEEEEGEETAAEDGEESQETAEETGEEEKEEKEAAGKEETEVKKKA
What is the function of this protein?
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber.  May additionally cooperate with the neuronal intermediate filament proteins to form neuronal filamentous networks (By similarity).
What are the official names of this protein?
Neurofilament light polypeptide, NF-L, Neurofilament triplet L protein.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cell projection, axon. Cytoplasm, cytoskeleton.
Protein: CLPP_XYLFT
Sequence: MDDVTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDYMANLIVAQLLFLEAENPEKDINIYINSPGGVVTAGMAIYDTMQYIKPAVSTICVGQAASMGALLLASGASGKRYALPNSRVMIHQPLGGFQGQATDIDIHAREILALRARLNEILAKHTGQSLETIAHDTERDNFKSAVDAQAYGLVDQVFGQRQEELIQSS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRG2_MOUSE
Sequence: MKFPLLLALLVGGASALHLSSETSDSKSPLMDENLPRDAEISGPEGEECPPGEELMPLEGEKEEGSGSEGVPGDEGAVSGQDVTDVDLQCPKEEDTTSLMGDSGCKTCRYLLVRRAECFDKAQSVCRRCYRGTLASIHSFSVNFGIQSAVRGINQGQVWIGGRIKGWGRCKRFRWVDGSSWNFAYWAAGQPCPGGGRCVTLCTQGGHWRLSHCVKRRPFICSY
What is the function of this protein?
Cytotoxin and helminthotoxin.  MBP also induces non-cytolytic histamine release from basophils.  It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).
What are the official names of this protein?
Bone marrow proteoglycan, BMPG, Proteoglycan 2.
What are the subcellular locations of this protein?
Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule (crystalloid core).
Protein: RS16_PSEPF
Sequence: MLTIRLALGGSKKRPFYHLTVTDSRNPRDGSHKEQVGFFNPVARGQEIRLSVNQERVAYWLSVGAQPSERVAQLLKESAKAAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: ARNT_ECO24
Sequence: MKSVRYLIGLFAFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWIVPHLLGLRYFEKPIAGYWINSIGQWLFGANNFGVRAGVIFATLLTTALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTWKGKSAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLAIAQREPDFWHYFFWVEHIQRFALDDAQHRAPFWYYVPVIIAGSLPWLGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILSCFASLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATFVVSPWGPMNTPVWQTFESYKVFCAWSIFSLWAFFGWYTLTNVEKTWPFAALCPLGLALLVGFSIPDRVMEGKHPQFFVEMTQESLQPSRYILTDSVGVAAGLAWSLQRDDIIMYRQTGELKYGLNYPDAKGRFVSGDEFANWLNQHRQEGIITLVLSVDRDEDINSLAIPPADAIDRQERLVLIQYRPK
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HTPX_PSEA8
Sequence: MMRILLFLATNLAVLVIASITLKLLGVDRFTGQNYGSLLVFCAVFGFAGSLVSLFISKWMAKMSTGTEVISQPRTRHEQWLLQTVEELSREAGIKMPEVGIFPAYEANAFATGWNKNDALVAVSQGLLERFSPDEVKAVLAHEIGHVANGDMVTLALIQGVVNTFVMFFARIFGNFVDKAILKNEDGPGIGYFVATIFAELVLGILASIIVMWFSRRREFRADAAGAHLAGTGAMIAALQRLRSEQGVPVQMPDTLNAFGINGGLKHGLAGLLMSHPPLEDRIEALRASAR
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSTS2_MYCTU
Sequence: MKFARSGAAVSLLAAGTLVLTACGGGTNSSSSGAGGTSGSVHCGGKKELHSSGSTAQENAMEQFVYAYVRSCPGYTLDYNANGSGAGVTQFLNNETDFAGSDVPLNPSTGQPDRSAERCGSPAWDLPTVFGPIAITYNIKGVSTLNLDGPTTAKIFNGTITVWNDPQIQALNSGTDLPPTPISVIFRSDKSGTSDNFQKYLDGASNGAWGKGASETFNGGVGVGASGNNGTSALLQTTDGSITYNEWSFAVGKQLNMAQIITSAGPDPVAITTESVGKTIAGAKIMGQGNDLVLDTSSFYRPTQPGSYPIVLATYEIVCSKYPDATTGTAVRAFMQAAIGPGQEGLDQYGSIPLPKSFQAKLAAAVNAIS
What is the function of this protein?
Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation (PubMed:15731097, PubMed:20933472).  Part of the ABC transporter complex PstSACB involved in phosphate import (Probable).
What are the official names of this protein?
Phosphate-binding protein PstS 2, PBP 2, PstS-2.
What is the protein family that this protein belongs to?
Belongs to the PstS family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GGACT_XENLA
Sequence: MTCYKHGKAVFKGMGKTVEKYPLVIAEEANIPFLLNIPGTGRRIIGEIYSVDEQLLHFLDDFEGCPNWYQRTPQEIEILEWEGTDDSPDERPAANSIITCFVYSTTCYQPEWLQLPYHKCYDAFGNHGLRYIRHRDII
What is the function of this protein?
May contribute to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue.  Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.
What are the official names of this protein?
Gamma-glutamylaminecyclotransferase, GGACT, AIG2-like domain-containing protein 1, Gamma-glutamylamine cyclotransferase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamylcyclotransferase family.
Protein: RNPA_ROSCS
Sequence: MKRAYRLRTPEQYQRVRRDGRTWDAGMLMLNAAPNRRRISRCGFIVAKRLGGAVVRNRIRRRVREAVRLLYPQIAPGWDMVFIARSPALAEIAFPQLQALVQRLLQRAGVVQGAVSETPDKD
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: CLD25_HUMAN
Sequence: MAWSFRAKVQLGGLLLSLLGWVCSCVTTILPQWKTLNLELNEMETWIMGIWEVCVDREEVATVCKAFESFLSLPQELQVARILMVASHGLGLLGLLLCSFGSECFQFHRIRWVFKRRLGLLGRTLEASASATTLLPVSWVAHATIQDFWDDSIPDIIPRWEFGGALYLGWAAGIFLALGGLLLIFSACLGKEDVPFPLMAGPTVPLSCAPVEESDGSFHLMLRPRNLVI
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
What are the official names of this protein?
Putative claudin-25.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: EFTU_RHIWR
Sequence: MAKAKFERTKPHCNIGTIGHVDHGKTSLTAAITKVLAETGGATFVDYANIDKAPEERERGITISTAHVEYETEQRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSATDGPMPQTREHILLARQVGVPALVVFMNKVDLVDDAEILELVELEVRELLSSYEFPGDDIPVIKGSAVKALDGTNDEIGRNAVLELMAAVDSYIPQPERPLDKPFLMPIEDVFSISGRGTVVTGRVETGMVKVGEEVEIVGIKDTRKTTVTGVEMFRKLLDQGQAGDNIGALIRGVGREEVERGQVLAKPGSIKPHTDFSSEVYVLSKEEGGRHTPFFANYRPQFYFRTTDVTGTVELPEGTEMVMPGDNVKLGVKLIAPIAMEEGLRFSIREGGRTVGAGVVSSISK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_PROMA
Sequence: MGQSTPLLVIGAGLAGSEAAWQIASAGIPVKLIEMRPCKRSPAHHSNDFAELVCSNSFGALSSDRASGLLQEELRILKSFVIKTADEHSVPAGGALAVDRNKFSSYITKKISSHPLITVQRDEIHSLPFENQISVLATGPLTSEHLAGDLKNFTGLEECHFFDAASPIIEGESIDFSLAFRASRYDKGDADYVNCPLNKDQYLKFRSELLSADQAEIKDFEKGVSNLFEGCLPIEELARRGEDTMRYGPLKPVGLWDNRWGDLHDKELRKTKRAYAVVQLRQEDKNGHLWNLVGFQTNLKWGEQKRIIRLIPGLQKAEFVRLGVMHRNTFIESPKLLNPTLQFRKRLNLLAAGQITGTEGYAAAVAGGWLAGTNAALIAMNRKPITLPETTMIGALLNFISEVSPKVKSNHKRDFQPMPPNFGLLPELNRRIRDKRCRYGAYRDRALEDIKKTQEFLEIGTPLGFKNQ
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB28_PROM4
Sequence: MSSSKINPAIQFYEGVDETAIPEIRLTRSKDGKTGQAIFVFQKPDALSEATTGDITGMTLIDDEGALKTREVKARFLNGEPSAIEATYTWKTESDFERFMRFAERYAKKNGLGYSSK
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COQ7_XANC5
Sequence: MTQISPTRLHSPLDRLLVEAQRALDTVFGNPPAERPNPAADTPDVVLDPEQRRHAAGLMRINHVGEVCAQGLYFGQAAVARDAHTQHHLLEAAQEETDHLAWCADRLHELDSRPSLFNPVWYAGSYALGALAGLRGDDWSLGFVVETERQVEAHLDEHLETLPQNDQRSRAILRVMKIDEARHADQAEQAGARPLPAPIPSAMALASKLMKTVAYRL
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SMRD3_HUMAN
Sequence: MAADEVAGGARKATKSKLFEFLVHGVRPGMPSGARMPHQGAPMGPPGSPYMGSPAVRPGLAPAGMEPARKRAAPPPGQSQAQSQGQPVPTAPARSRSAKRRKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRVDIQEALKRPMKQKRKLRLYISNTFNPAKPDAEDSDGSIASWELRVEGKLLDDPSKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTPTTQETDGFQVKRPGDLSVRCTLLLMLDYQPPQFKLDPRLARLLGLHTQSRSAIVQALWQYVKTNRLQDSHDKEYINGDKYFQQIFDCPRLKFSEIPQRLTALLLPPDPIVINHVISVDPSDQKKTACYDIDVEVEEPLKGQMSSFLLSTANQQEISALDSKIHETIESINQLKIQRDFMLSFSRDPKGYVQDLLRSQSRDLKVMTDVAGNPEEERRAEFYHQPWSQEAVSRYFYCKIQQRRQELEQSLVVRNT
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).  Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.  Stimulates nuclear receptor mediated transcription.  Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).  During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.  The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.  As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).  The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.  The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3, 60 kDa BRG-1/Brm-associated factor subunit C, BRG1-associated factor 60C, BAF60C.
What is the protein family that this protein belongs to?
Belongs to the SMARCD family.
Protein: TSAD_PROM0
Sequence: MHKVLAIETSCDETSVSIVSNIGDTFRIHSNIIASQIEDHSKWGGVVPELAARKHLELLPFVLEKALEQAKIKIEEVDYIASTVAPGLVGCLRVGSITARSLCMLHSKPFLGIHHLEGHLSSILFSENYPKKSFLTLLVSGGHTELIKVDDNRGMQRLGKSFDDAAGEAFDKVGRLLGLGYPGGPAIEKIAKNGDPMKFNLPKCRISDKKGGFLKYDFSFSGLKTAVLRLVERINLAGKTVPIPDIAASFERVVAEVLVERTIKCAEDHRLDNVVVVGGVAANNTLRKMMISEASKKSIKVHLAPLDLCTDNAAMIGAAALFRIKFKDHLSNLKLGVAGRLSIEQANTLYEENPPF
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRP36_YEAS6
Sequence: MSYYFKNLKPDLNSDVEEDDGNLLESIMANKSKREIDEQESSDDELKTLSFGSLKKAETIIDEEDFKDTKPVHKKPITTTYREESFDEDDDSEDKSDEDAGFFEEDSEDETHHGQKVPKKKSKHAPIEQSSKKRVPRVRNIPGLEIPRNKRSNLYQDIRFDKSTGKALDSSIIRKRYQFLDEYREKEIDELQKLLQDRKFLSKIDQGEREEMEQRLKSMKSRLQSMKNKDLEREILKEYESDMNKNNNTRYHLKKSEKRKVVQKWKFDHMKAKQREKVMERKRKKRLGKEFKQFEFHNRR
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
What are the official names of this protein?
rRNA biogenesis protein RRP36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: LIPA2_SYNY3
Sequence: MPQQSFMNGSSLPREFPPRLPSWLKRPIGRASELSTVQQIIKQRQIHTICEEGRCPNRGECYANRTATFLLMGQICTRACGFCQVEKGQAPMMLDQDEPRKVAEAVQLLGLKYVVLTSVARDDLTDGGAGWFVAVMERIRQDNPATQIEVLTPDFWGGMGRERSQKERVLTVTKAKPVCYNHNLETVARLQGKVRRGAKYQRSLDVLRWIKEFDPDIFTKSGLMLGHGETVDEVVETLKDLRSVGCDRLTLGQYMQPSLDHLPVQKYWTPEEFDQLGEIAKDLGFSHVRSGPLVRSSYHAGED
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase 2, Lip-syn 2, LS 2, Lipoate synthase 2, Lipoic acid synthase 2, Sulfur insertion protein LipA 2.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_BACC1
Sequence: MKPNFSKGLLPAVVIEEDTKEVLMLAYMNEEAYEKTIETKRTWFYSRSRRSLWNKGETSGNVQHVQSLYLDCDQDSIVVVVKQVGPACHTGEKTCFHYKII
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TLP_CLOB6
Sequence: MKNKPDDRRDNVDKIQYNITKTIQNCELADEMIAKTDDEKTKKTLIEKNQRRREALDGMREEIKDEARDKKNGYM
What are the official names of this protein?
Protein Tlp homolog.
What is the protein family that this protein belongs to?
Belongs to the Tlp family.
Protein: RNFC_PASMU
Sequence: MDVLTRFNSGKLWDFKGGVHPPERKSQSNQKPIRHAKLVEHFYIPVVQHAGEAGNILVKVGDYVFKGQPLTQGDGLRVLPVHASTSGFIRAIAPYASAHPSGLATLCLHLEADGKDQWREQQPLDDFLTQTPEKLIEKLYQAGVAGLGGAVFPTAAKLHSAEKQVKLLIINGAECEPYITCDDRLMRDYADEIIEGTRILRYILRPEKVVIAVEDNKPEAVAALRQVLQGANDIEIRVIPTKYPSGAAKQLIQILTGMEVPSGQRSSSIGVLMQNVATAFAVKRAIMDDEPLIERVVTLTGDKVRHKGNYWVRLGTPIYQLLQQVDYHYDDRFPVFMGGPMMGFILPDLQAPVTKMTNCLLAPDHFEYAPPAPEQSCIRCSACSDACPVSLMPQQLYWFARSEDHEKSEEYALKDCIECGLCAYVCPSHIPLIQYFRQEKAKIWEIQQKAKQAEEAKQRFEARQARLAREEQERKARAQKAMEARRQEMKTAQGIDPVQAALERLKAKKTDNDSSAKVEIKTIVTEKGDILPDNSDIMAQRKARRLARQQQTQNTDVSQVETNEENKSTDSKSAVAAAIARAKAKKAAQQGSALEKDEISSSDTLSVGNDTEPVAEDPRKAAIAAAIARAKAKKAAQQGSAVEKDEISSSNTLSVGNDTEPVADDPRKVAIAAAIARAKAKKAAQQGSAVEQDEISSSDTLSIGNEAEPVADDPRKAAIAAAIARAKAKKAAQQRSAVEQDEISSSDTLSVGNETESVAEDPRKAAIAAAIARAKAKKAAQQRSAVEQDEISSSDTLSVGNETESVAEDPRKAAIAAAIARAKAKKAAKANNHDA
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rnf electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.