PharMolix/UniProtQA huggingface dataset:
Protein: ANR10_CHICK
Sequence: MSLGAGPEAGFSSEELLTLRFPLHRACRDGDLPALCALLQSAPRSDLAAEDSFYGWTPIHWAAHFGKLECLMQLVRAGASVNASTTRFAQTPAHIAAFGGHPQCLNWLIQVGANINKQDYVGETPIHKAARSGSVDSISALVAHGAQIDLRNASGLTAADLAHTQGFQECAQFLLNLQNCHLNRYYSNGTLNGGHRNAGPNPFSGGTSRKRSFEDVESAGVKKARTEAYSFDGLIPMMNGGVEDDADNMHVDREFAVVSDMNSSSSILNALTNGCAMNGHLDFTAAQQLSGMDTRQEECLTLAPNGIIPGVTSPSRHRIHTSNGTEEPEKAMNNPTDMCGSLHLNGSPSSCVSNRPSWVEDPGDTLHYGHYHGFGDTAESIPELSSVVEHSNSVKVEQRYDNTVLGTMYLYHGS
What are the official names of this protein?
Ankyrin repeat domain-containing protein 10.
Protein: RNC_PSEPF
Sequence: MSVSLSRLERQLGYTFKDQELMVLALTHRSFAGRNNERLEFLGDAILNFVAGEALFDRFPLAREGQLSRLRARLVKGETLAVLARGFDLGDYLRLGSGELKSGGFRRESILADALEALIGAIYLDAGMEVARERVLAWLAGEFEGLTLVDTNKDPKTRLQEFLQSRGCELPRYEVVDIQGEPHCRTFFVECEVVLLNEKSRGQGVSRRIAEQVAAAAALIALGVENGND
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPS_CORGL
Sequence: MSSPSAPLATPDVELDVHTLSSENLPWLCIVWDDPVNLMSYVTYVFQTVLGFSKKRATELMMQVHTEGKAVVSSGEKDKVEGDVKKLHTAGLWATMQQAG
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: USTZ_USTVR
Sequence: MASHHQLLCLNILGFRKPGISTEDYRNYMVNVHAPLVAGLMEKYGFLHFTMSHASEQSPQLMDQLYDAQFANTASYDCCVQIVFPSIECFVNMKADPYFKQTVGPDHEKFADTKRSQMMIGWFSPLLINGQQTDSLSAAE
What is the function of this protein?
Dehydratase; part of the gene cluster that mediates the biosynthesis of ustilaginoidins, dimeric gamma-naphthopyrones isolated from different fungal species (PubMed:31050129).  The first step in the biosynthesis of ustilaginoidins is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase ustP, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:31050129).  YWA1 is then probably substrate of the ustZ to yield norrubrofusarin via a dehydration reaction (Probable).  A key enzyme in the biosynthetic pathway is the laccase ustL, which catalyzes the oxidative dimerization of norrubrofusarin to ustilaginoidin A (PubMed:31050129).  It can produce the M- and P-atropisomers in varying amounts, depending on the reaction conditions (PubMed:31050129).  For the biosynthesis of 3-methylustilaginoid in derivatives such as chaetochromin A, a methylated derivative of YWA1 is required (Probable).  The C-methylation is considered to be catalyzed by ustM, the phosphopantetheine attachment site of which indicates that it acts on the growing polyketide chain before release of the product (Probable).  For the biosynthesis of chaetochromin A, it is assumed that saturation of the D2 double bond takes place before dimerization, and is probably catalyzed by an external reductase because no candidate gene was identified within the cluster (Probable).
What are the official names of this protein?
Dehydratase ustZ, Ustilaginoidins biosynthesis cluster protein Z.
What is the protein family that this protein belongs to?
Belongs to the tpcK family.
Protein: METN_WOLSU
Sequence: MLDQISLEIPKGTIYGLVGHSGAGKSTLLRTINGLEGFDEGELWVDGVDLQSLQGDALRVFRKNIGMIFQHFSLMARQNVFENVALPLRCWKYPEAEIQKRVFNLLSLVGLESKSDSYPSALSGGQKQRVAIARALTLEPQILLSDEATSALDPSMTQSILDLLQTINQELGVTVVLVTHEMEVVKKLCHHAAFLEGGKLLRSGNIEELFLQPDPKMRHFLGESEVLPKEGVNIRLYFPKEVAQNPIITQMARQLSLDFSIVWGKLERFGEDVLGSLVINIPEARQEEAERFLESSGVRWEVL
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PANC_SOLM1
Sequence: MEIIKEPSALRELAGQWTRQGRSVGFVPTMGYLHAGHESLMRLARGRAETVVASVFVNPTQFGPGEDLNAYPRDLERDAALAKAAGVDVLFAPSPEAMYEPAAATWVEVPTLARHLCGASRPTHFRGVCTVVSKLFLLVRPTVAVFGQKDWQQLAILRRMNADLGFGVEIVGGPIVREADGLALSSRNVRLTPQEREQAPGINQGLALAEAMVRDGETAAGRILDAVRAHYAAHVPLGEIDYLSCVDPDSLEMVEPIDRPALFATAVRFSAVRLIDNRLAADLPR
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_CALBD
Sequence: MLNFLQSVQFVKEVEKKIIEYDKDIAFNEAIILYEIAKHDADLVKNLASTINQHYFKNTIELCSIYPAKVGLCPQDCKFCSQSIHHSCLIEIKDLAALDEVIEYLEYVISFPIKRFCLVTSGEKLDDSEFEKILDIYSHISKNYNILLCASLGFLTQERAKKLLKVGVVKYHNNLETSSTYFKNICSTHTQQQKIETLKIAKEAGLQICSGGIISMGEDMIERIKLAFELRELDVDSVPINILNPIKGTPLEDIKIIDKNEIFITLALFRIVLPKKTILLAGGKENALGDMEKMAYECGVNGCMVGNYLTTRGMGIREKIEMLESLDLKFQTNMHNN
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: MPRA_MYCVP
Sequence: MPVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGREALDLIASDRPDAVVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTTPDDGAGESAAMTFSDLSLDPVTREVTRGDRPISLTRTEFSLLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
What is the function of this protein?
Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host.  Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).
What are the official names of this protein?
Response regulator MprA, Mycobacterial persistence regulator A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4700_BURL3
Sequence: MDIAHDLQSIGAQEQALVFPHFDPARAWALGNRMHALATSRGHAIAIDIVTFGQPLFYAALAGATPDNADWVRRKRNVVAHFRRSSYAIGLRMQQAGATLADKHGLPIAEYSPHGGSFPLTVAGAGVIGSITASGLPQRADHEFVVEALCAELGHDYAVLALARS
What are the official names of this protein?
UPF0303 protein Bcep18194_A4700.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: IRAD_ECO27
Sequence: MMRQSVQTVLPESTGNNTLSLRDSVCRDLFQLFSSPHSPLPILLVSGMPEWQGHNQSDKLLQSWYCRQLRSALLFHEPRIAALQVNLKAVYCHELVISLDMMLYHDDEPLTFDLVWQKGSWHRTMPQ
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraD.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family. IraD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR48_DROPE
Sequence: MLTHKTCQARKKMQVSFVIRDAEEKQHRNGVNSLQLDPNNGKLYSAGRDAIIRVWNTRSESSEKYIQSMEHHNDWVNDIVLCCNGRNLISASCDTTVKVWNAQKGFCMSTLRTHRDYVQALAYAKDREQVASAGLDKAIFLWDVNTLTALTASNNTVTTSSLTGSKDSIYSLAMNPSGTVIVSGSTENILRIWDPRTCMRSMKLRGHTENVRCLVVSPDGNQVVSGSSDGTIKVWNLGQQRCVQTIHVHKEGVWSLLMSENFQYIISGSRDQNIIVTEMRNPSNKTLVCEEKAPVLSLGYNMDKTGVWATTWNSDIRCWKLPMYDRGTLNSSGGLDAQWTQGGTELACIKGGAAIKECTVLNDKRYILTKDSQDQVVLYDVLRVVKKDTLGPIDYEAEVKKRNKQVYIPNWFTVDLKTGMPTIVLGQEEVDCFSAWVSIEAGLPECVDPTTEIKINYGKLLLEALLEYWTPPHSIPQNELEPDMHGNGYFQVPKHTPVIFSEVGGRTVCRLLVRDAAGDSECTLLHETAPQWVTDVVIEKNIPKFLKIPFFLQPHPQMTKPERTKKDRLVANEFIQCRKVCEHVLEKVLNAETTPSGANANNSLQNSQSDGNSEGSQLPAEERIELSCNDVVVDPNMDLRTVRHFIWKQSTDLTFQYKTKQNFNYDGSIGDSLERVTRKY
What is the function of this protein?
Regulator of deubiquitinating complexes.  Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity).
What are the official names of this protein?
WD repeat-containing protein 48 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR48 family.
Protein: Y321_ROSDO
Sequence: MTALYIDADACPVKSEAERVATRHRVKMYIVSNGGLRPSQNPLVETVIVPDGPDVADMWIADRCGTGDVVVTGDIPLAAKCIEAGALVLKHNGEALTSANIGNVLASRDLMADLRAADPFRQGGGKSFGKADRSRFLDGLERTLRKAATLG
What are the official names of this protein?
UPF0178 protein RD1_0321.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: HISX_PSESM
Sequence: MTTPTAIRRLDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVELTQKFDGLQVASMAELILPRERLELALTRITPVQRQALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQVGIDMIAGPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMARAAIVETSINGRGALIKVADMAQAIEVANRIAPEHLELSVADPEAWLPHIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIYCSPEGASELGKTASVLARGESLSGHARSAEYRITDLDWKTGNLEEGK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: Y2242_SHEPW
Sequence: MRLSQSVLTALLICVNSAAFANVEVTLPSNSELVLVNGKESDSTDKLTLENGENQLALRYIGRYQQQGSQTQFSSDVIIMTFLAENTSLTIALPRIRSNSAADAFNRDPKISLKNSSEVDIAFRQDKLLKEGMQLGRDYEKEVAEYNSNNQVASVAALAPSITALVQAKPVVIENHGQPKNTINQSDQVNVGQMLDFWYQQADEETRKAFKLKINSKE
What are the official names of this protein?
UPF0319 protein swp_2242.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: HRCA_POLSJ
Sequence: MLDDRARLLLKALVERYIADGQPVGSRTLSRASGLELSPATIRNVMSDLEELGLIVSPHTSAGRIPTARGYRLFVDTMLTTQRDQLSAGHITAPRLAPDQPQKVISNAAHMLSSLSQFVGVVMAPRRTSVFRHIEFLRLSEKRFLVIIVSPDGDVQNRVIFTEADYTQSQLIEASNFLNSHYAGMAIEEVRERLQNEVEALRGEIATLMQAAVQVSSEAIESRDEVVVSGERNLLAVSDFSSDMGNLRKLFDLFEQKAQLMRLLDVSSRAEGVRIYIGGESQVIPYQELSVVTAPYEVDGQVVGTLGVIGPMRMPYEKMIQIVDITSKLVSTALSHSK
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: TDPZ4_MOUSE
Sequence: MSGELEAKSRGDTQSHEQKLCYRWTISNFSFFVEETEEYITSLVFSLEDNDKMTWCLRVYPTGVDEKNKDYVSLYLILLSCEKGSVWAKFEVCILNAKGEKCNTERIPSFSRIQPHQPFGFEKFITRDSFLSPAQVLTPDDKFTLLCKVSVLQDSFSISGQNPRPAIKVTRCTLENDVGELWENPLFTDCSLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLTNCVEIHDLDPQVFKEMMGFIYTGKVPHLHSHSMACDLLAAADRYGLEDLMVMCEDALCRSLSVENAAHTLIVADLHSTEHLKTQALDFIIVYASEVSKTSGWMSMVESHPRLVAEAFHSLASAQRVFWALPFKQLKWSLRPTQL
What are the official names of this protein?
TD and POZ domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the Tdpoz family.
Protein: RLMN_STAES
Sequence: MITAEKKKRNKFLPNFEKQSIYSLRYDEMQQWLIDHGQQKFRAKQIFEWLYQKRVNTIDEMTNLSKELRQILKDHFAMTTLTTVVKQESKDGTIKFLFELQDGYTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVSQVLTVQKALDETNERVSQIVIMGIGEPFENYDEMMDFLRIVNDDNSLNIGARHITVSTSGIIPRIYDFAEEDIQINFAVSLHGAKDEIRSRLMPINRAYNVDKLMEAIRYYQEKTNRRVTFEYGLFGGVNDQLEHARDLAHLIKNLNCHVNLIPVNHVPERNYVKTPKDDIFKFEKELKRLGINATIRREQGSDIDAACGQLRAKERQVETR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  Confers resistance to some classes of antibiotics.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB18_DICDI
Sequence: MEEDKQYKVLLIGDSDVGKTSIVKRFSDDTFDEDLLCTIGVEFKMKEVKVDGKKVDLCIWDTAGQEKFRALISSYYRGAHGIILTYDVTKRESFDNLNYWLNEVENFANRSNLVKLLVGNKIDKENREVTREEGAEFAKKKAMLFIECSAKSKIGIQQAFEELAQKIIEIPQNTSSSQPKQRNTGSVKVEDEPDHNQGVCSC
What is the function of this protein?
Plays a role in apical endocytosis/recycling.  May be implicated in transport between the plasma membrane and early endosomes (By similarity).
What are the official names of this protein?
Ras-related protein Rab-18.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
Protein: MMAA1_MYCTU
Sequence: MAKLRPYYEESQSAYDISDDFFALFLDPTWVYTCAYFERDDMTLEEAQLAKVDLALDKLNLEPGMTLLDVGCGWGGALVRAVEKYDVNVIGLTLSRNHYERSKDRLAAIGTQRRAEARLQGWEEFEENVDRIVSFEAFDAFKKERYLTFFERSYDILPDDGRMLLHSLFTYDRRWLHEQGIALTMSDLRFLKFLRESIFPGGELPSEPDIVDNAQAAGFTIEHVQLLQQHYARTLDAWAANLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGLINVAQFTMTK
What is the function of this protein?
Involved in the conversion of a cis-olefin into a trans-olefin with concomitant introduction of an allylic methyl branch at the proximal position of the precursor to both the methoxy and ketomycolic acids.  It directly affects the cis- to trans ratio and indirectly affects the keto to methoxy ratio.
What are the official names of this protein?
Mycolic acid methyltransferase MmaA1, S-adenosylmethionine-dependent methyltransferase, AdoMet-MT, SAM-MT.
What is the protein family that this protein belongs to?
Belongs to the CFA/CMAS family.
Protein: RL7_ECOUT
Sequence: MSITKDQIIEAVAAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPVEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKALEEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: BUK2_THEMA
Sequence: MFRILTINPGSTSTKLSIFEDERMVKMQNFSHSPDELGRFQKILDQLEFREKIARQFVEETGYSLSSFSAFVSRGGLLDPIPGGVYLVDGLMIKTLKSGKNGEHASNLGAIIAHRFSSETGVPAYVVDPVVVDEMEDVARVSGHPNYQRKSIFHALNQKTVAKEVARMMNKRYEEMNLVVAHMGGGISIAAHRKGRVIDVNNALDGDGPFTPERSGTLPLTQLVDLCFSGKFTYEEMKKRIVGNGGLVAYLGTSDAREVVRRIKQGDEWAKRVYRAMAYQIAKWIGKMAAVLKGEVDFIVLTGGLAHEKEFLVPWITKRVSFIAPVLVFPGSNEEKALALSALRVLRGEEKPKNYSEESRRWRERYDSYLDGILR
What are the official names of this protein?
Probable butyrate kinase 2, BK 2, Branched-chain carboxylic acid kinase 2.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_RUTMC
Sequence: MSIDTQAIIKKYQSKTGDTGSSNVQIALLTARIKHLTEHFKTHKKDHHSRRGLLHLVSQRKKLLIYLKDANTASYSNLIIHLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: S36A4_XENLA
Sequence: MDATELGVSGEGEEIDMEVMRPLIESEDRFEGTYGEKKHLQRYLNSDNKKDEEVMKPLIENEDDSDGTCDEHQYLQRHPDLDNKDGLTFFQTLIHLLKGNIGTGLLGLPLAMKNAGVLLGPISLLFFGIISIHCMNILVRCSHFLCQRYKKANLGYSDTVGLALEVGPGVLQRHASFGRNLVDWFLVVTQLGFCSVYFVFLAENIKQVFEVFLETKLQQSEIGIWSLDLRIYMFSFLPLIIPLVFIRDLKNLSLLSFFANVSMAISLLIVYQYVIRNLSDPRTLPLGTSWKTYPLFFGTAIFAFEGIGVVLPLENRMRDKKDFSKALNIGMAIVTTLYISLATLGYFCFGDQIKGSITLNLPQDSWLYQLVKILYSFGIYVTYAIQYYVPAEIILPAVTSRVQKTRKLLCEFTMRFFLVCLTCAVAVLIPRLDLVISFVGAVSSSTLALILPPLVEIITYHKENLSPWVIMKDVGIAVIGFVGFIAGTYVTIEEMIYPISYVPPNVSHSDFGVLNNTVLEGH
What is the function of this protein?
Uniporter that mediates the transport of neutral amino acids like L-tryptophan, proline and alanine.  The transport activity is sodium ions-independent, electroneutral and therefore functions via facilitated diffusion.
What are the official names of this protein?
Neutral amino acid uniporter 4, Solute carrier family 36 member 4.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: APT_SHEAM
Sequence: MNTDSLALIKQSIKTIPDYPKAGIMFRDVTSLLEDHTAYQTAMKLLVERYKDSGFTKVVGTESRGFLFGAPLALELGVGFVPVRKPGKLPRETISESYELEYGHDTLEIHVDAIKAGDKVLVIDDLLATGGTIEATVKLIRRLGGDVAHAAFVISLPDLGGEKRLQAMGLEICKLCEFEGD
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EASA_CLAFS
Sequence: MSSSNLFKPIPLGRKVLQHKVVLSPMTRFRADNDGVPLSYVKSYYGQRASIRGTLLITEAVAICPRAKGFSNCPGIWHQDQIAAWKEVVDEVHSKGSVIWLQLWATGRASDADTLKESGFHLESSSDVPVAPGEPVPRPLSEDEIESYIRDYVTGAINAVQGAGFDGIEIHGANGFLVDQFLQASCNTRADQWGGSIENRSRFGLEITRRVVDAVGKDRVGVKLSPWSTFQGMGTMDDLVAQFEHFISRLREMDIAYIHLVNTRWLEEEEPGIKTHPDVDNQTFVRMWGNKTPILLAGGYDADSARRLVDETYSDQNNIMVVFGRHYISNPDLPFRLRLGIPLQKYNRDTFYIPFSDEGYLDYPFCQEFLDQQDVDQVVVAA
What is the function of this protein?
Probable inactive dehydrogenase; part of the gene cluster that mediates the biosynthesis of fungal ergot alkaloid (PubMed:17720822).  DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (By similarity).  The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity).  The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by easD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (By similarity).  Agroclavine dehydrogenase easG then mediates the conversion of chanoclavine-I aldehyde to agroclavine via a non-enzymatic adduct reaction: the substrate is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione (By similarity).  Further conversion of agroclavine to paspalic acid is a two-step process involving oxidation of agroclavine to elymoclavine and of elymoclavine to paspalic acid, the second step being performed by the elymoclavine oxidase cloA (PubMed:17720822).  However, cloA does not encode a functional enzyme indicating that C. fusiformis terminates its ergot alkaloid pathway at elymoclavine (PubMed:17720822).
What are the official names of this protein?
Probable inactive dehydrogenase easA, Ergot alkaloid biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Protein: RL15_ECO8A
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: CYB_SALCN
Sequence: MTNIRKSHPLIKIINESFIDLPAPSNISAWWNFGSLLGVCLILQILTGLFLAMHYTSDTATAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHIGRGMYYGSYTFSETWNIGILLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAAVHLLFLHETGSNNPSGLTSNSDKIPFHPYYTIKDILGLLLLIMALMLLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVVALVLSILILAVMPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFITIGQLASILYFFTILVLMPISSMIENRFLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EURL_MOUSE
Sequence: MNEEEQFVSIDLNDDNICSVCKLGTDKDTLSFCHICFELNLEGVPKSNLLHTKSVRGHKDCFEKYHLIANQDCSRSKLSKSTYEGVKTIVSKKINWIVQYAQNKNLDLESECSKTSQHPLLNFRHKPEKKLLPQFDSQVPKYSAKGSAGNAGSISSYAQRILEHRENTDFRLGLLEDADALWTHSHSQAQKTEETSSGPEGTIQTQNPHYSREELNSMTLAEVVQLSAKLQQRIQEVFEELTHQVQEKDSLASELHVRHVAIEQLLKNCSKLPCLQVGRTGTRSHLPMNH
What is the function of this protein?
Plays a role in cortical progenitor cell proliferation and differentiation (PubMed:27404227).  Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway (PubMed:27404227).
What are the official names of this protein?
Protein EURL homolog.
What is the protein family that this protein belongs to?
Belongs to the EURL family.