PharMolix/UniProtQA huggingface dataset:
Protein: ASPL1_ARATH
Sequence: MVSRSAFLLFCVLFLATEETLASLFSSRLIHRFSDEGRASIKTPSSSDSLPNKQSLEYYRLLAESDFRRQRMNLGAKVQSLVPSEGSKTISSGNDFGWLHYTWIDIGTPSVSFLVALDTGSNLLWIPCNCVQCAPLTSTYYSSLATKDLNEYNPSSSSTSKVFLCSHKLCDSASDCESPKEQCPYTVNYLSGNTSSSGLLVEDILHLTYNTNNRLMNGSSSVKARVVIGCGKKQSGDYLDGVAPDGLMGLGPAEISVPSFLSKAGLMRNSFSLCFDEEDSGRIYFGDMGPSIQQSTPFLQLDNNKYSGYIVGVEACCIGNSCLKQTSFTTFIDSGQSFTYLPEEIYRKVALEIDRHINATSKNFEGVSWEYCYESSAEPKVPAIKLKFSHNNTFVIHKPLFVFQQSQGLVQFCLPISPSGQEGIGSIGQNYMRGYRMVFDRENMKLGWSPSKCQEDKIEPPQASPGSTSSPNPLPTDEQQSRGGHAVSPAIAGKTPSKTPSSSSSYSFSSIMRLFNSLLLLHWLASLM
What are the official names of this protein?
Aspartic proteinase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: RB24A_XENLA
Sequence: MHTTQKDTTYTKIFVGGLPYHTTDSSLRKYFEVFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQIHPALIQRPFGIPAHYVYPQAYVQPGVVIPHVQPTAATSTSPYIDYTSAAYAQYSAAAAAAAYDQYPYAASPAATGYVTAAGYGYAVPQPLTAAAPGSAAAAAAAFGQYQPQQLQADRMQ
What is the function of this protein?
Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation.  Plays a major role in pre-mRNA alternative splicing regulation.  Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation.  Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing.  Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes.  Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound.  Involved in myogenic differentiation by regulating myog levels (PubMed:20338237).  Binds to a huge amount of mRNAs.  Required for embryonic heart development, sarcomer and M-band formation in striated muscles (PubMed:20338237).
What are the official names of this protein?
RNA-binding protein 24-A, RNA-binding motif protein 24-A, RRM domain-containing protein SEB-4, SEB-4, Xseb-4.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GLYA_AFIC5
Sequence: MPSSAQNASTPNTFFTASLAAADPEIADAIKGELGRQQHEIELIASENIVSRAVLEAQGSVMTNKYAEGYPGKRYYGGCEWVDVAETLAIERAKKLFGAQFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLAAGGHLTHGSPVNMSGKWFKAAHYTVRRDDQLIDMDEVAKQAEQVKPKLIIAGGSAYSRPWDFKRFREIADSVGAYFMVDMAHFAGLVAGGVHASPVPHAHVTTTTTHKSLRGPRGGLILTNDEDIAKKINSAIFPGLQGGPLMHVIAAKAVAFKEALQPDFKVYAKNIVENARALAETLRGHGFEIVSGGTDNHLMLVDLRPKGLKGNISERALVRSGLTCNKNGIPFDPEKPFVTSGLRLGTPATTTRGFGVAEFKQVGALIAEVLNAVAQSPDGAAPGVEESVKKRVRELTDRFPIYS
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGB_LISMC
Sequence: MQLITTENKLAGSKKALEIIEKGITSGEVNTLGLATGSTPETLYAELVKSDVDTKNVTTTNLDEYVGLAANDPNSYHYYMNELLFSKKAFKESFLPNGEATDAEAECARYEEILSEHPIDIQVLGIGTNGHIGFNEPGTPFDSLTHKVVLTDSTREANKRFFEREEDVPTHAYSMGIKSIMNAKKIILLAFGENKAQAIKETIKGPVDVNCPASVLQNHPDVTVILDNEAASLL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: YIDC_FUSNN
Sequence: MSYIYNLLKQFLAFLLNTTDKYVGNFGISIIIVTILIKIILLPLTLKQDKSMKEMKKLQPELEKIKQKYANDKQMLNIKTMELYREHKVNPLGGCLPILVQLPILFALFGVLRSGIIPADSSFLWMRLADPDPFYVLPVLNGAVSFLQQKLMGTSDNAQMKNMMYVFPIMMIVISYRMPSGLQLYWLTSSLIAVIQQYFIMKKGA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL22_LEUMM
Sequence: MAEQVTSARATAKIVRVAPRKARLVLDTIRRKSVNEAYAILKFLPNTSTEDIYKVLNSAVANAENNFSLDREDLIVKEAFANEGPTLKRFRPRAKGSASPINKRTSHLTIVVAEKEAK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: Y1813_MYCTO
Sequence: MITNLRRRTAMAAAGLGAALGLGILLVPTVDAHLANGSMSEVMMSEIAGLPIPPIIHYGAIAYAPSGASGKAWHQRTPARAEQVALEKCGDKTCKVVSRFTRCGAVAYNGSKYQGGTGLTRRAAEDDAVNRLEGGRIVNWACN
What are the official names of this protein?
Uncharacterized protein MT1861.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1269c.
Protein: UNG1_STRAW
Sequence: MAPRPLHELVEAGWAKALDPVAGRIAAMGDFLRAEVAAGRTYLPAGANVLRAFQQPFDDVRVLIVGQDPYPTPGMAIGLSFAVSPEVRSLPGSLENIFRELHTDLGLPRPSNGDLTPWTEQGVLLLNRALTTAPRKPAAHRGKGWEEVTEQAIRALVARGTPLVSVLWGRDARNLRPLLGDLPAIESAHPSPMSADRGFFGSRPFSRANELLVRQGAQPVDWRLP
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase 1, UDG 1.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAMC_STRCO
Sequence: MTAATVRGGTPRDSVVSVSNRWEGAGVNKGYAVYCDADPYFYDAPHRTADRTGAARSRYAAASSPVPEGWQRHESGDWLALRPADADLPAQGWKIHVSACLDNAESVLDRVWRHCVDGGTAFKFVPSRYLLHQRNAKYADRAGSGKFVTVYPADEAEFERLVGELSELLAGEPGPHILSDLRIGDGPVHVRYGGFTRRDCYDADGELRPAVSGPDGVLVPDLRGPVFRIPEWVDPPAFLRPHLDARSAVTVTGMPYTVESALHFSNGGGVYLARDTRTGARVVLKEARPHAGLAADGADAVTRLHRERRALERLSGLACTPEVLDHRTVGEHHFLVLEHIDGKPLNTFFARRHPLIEADPGERRLAEYTDWALDVHARVERAVAEVHARGVVFNDLHLFNIMVRDDDSVALLDFEAAHHVDEAGRQIVANPGFVAPPDRRGVAVDRYALACLRIVLFLPLTSLLAVDRHKAAHLAEVVAEQFPVDRAFLDAAVEEITRVDGSTRVDGSTRADETTRADETTRLDVTTRVHGAPDAARRPAGPVAPVRPDDWPRSRDSMAAAIRASATPSRTDRLFPGDIAQFATAGGGLAFAHGAAGVLYALAESGAGRDEDGEQWLLERTKRPPSGMPLGFHDGLAGLAWTLERLGHRDRALDLAELLLDQPLDHLGPDLHGGTAGLGLALESLAATTGQAALHSAALHCAELAADGLPGGSVPADRVSRGRARAGLLYGGAGRALLFLRLFERTRDSALLDLARDALRQDLARCVRGAGGALQVDEGWRTMPYLGAGSVGIGMVLDDYLAHRADEEFARAANEIVAAAQAMFYAQPGLYRGVAGMVLHLGRTTATAPGTGPRAVRRQLDALSWHAMSYRDRLAFPGEQMMRLSMDLSTGTAGCLLAVASVLGDAPAGLPFLPPPRRSGGPLTRPHQEP
What is the function of this protein?
Required for aerial hyphae formation (PubMed:12169618, PubMed:12100547, PubMed:12453210).  Probably involved in processing the precursor of SapB to its mature form (Probable).
What are the official names of this protein?
Probable SapB synthase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: KCY_SALEP
Sequence: MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFREAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQENGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQKLALA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBTD1_MOUSE
Sequence: MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAGNSAISVEGFSWGNYINSNSFIAAPVACFKHAPMGTCWGDISENVRIEVPNTDCSLPTKVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQDGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPPASQSSRESQSASSKQKKKAKSQQYKGHKKMTTSQLKEELLDGEDYSFLHGASDQESNGSATVYIKQEP
What is the function of this protein?
Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR).  MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively).  In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me.  Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR).
What are the official names of this protein?
MBT domain-containing protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MNMG_TREPA
Sequence: MGFRFSDYDVIVVGGGHAGAEAALAAARMGEHTLLITQTIDSIGRLSCNPSIGGISKGNIVREIDALGGEMGKFADACMIQYRLLNKSRGPAVQAPRIQADKFLYAQKVKYTLECTQHLHLYQDTVVDVVCSNTTDAGYVAYGAAHAVVTARGRRISARAVVLTTGTFMEGRVYIGEYEAPEGRLGEHAAEGLGAALRKKGFQMGRLKTGTPARVLRKSVDLSVMEKQEADAIMRPFSFAHVEINRPHADCYINYTNERTHQLIRENFHRSPFFSGRIKAVGTRYCPSIEDKVRKFPDRIRHQLYIEPEGLDTEELYINGLSSCLPEDIQDEMIRTIPGMERAVITRPAYAVDYAVLFPVQLGIDLQTKRVSGLFSAGQINGTSGYEEAGGQGIIAGINAALYARSTKTKEEYHPFVLKRDEAYIGVMIDDLVTQGIDEPYRMFTARAEYRLKLRHDTADERLTEKAYAIGLQKKSAVETLQKKMRTKHEILHLLQTNKVSLTHANAYVQLKPHIGKSFAATLRDPVIPLGLIASLNEQIAQFPLEVFQSVGVEIRYEHYIAAQDQRIAQVEKMEGIKIPAHFDYARISGLSVESRTRLEHVRPDTIGQVGRMRGIRPSDVMLLLAHLKR
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECB_CHLTR
Sequence: MSSFDIFSPTASVSGKFFLEASAGTGKTFTIEQVVLRSLLEGSIEQTKNILVVTFTNAATNELKLRIQASLKQALSLFSQALSHPGTPLPPYISSSETKVKQLYMKIRNSLATLDEMNIFTIHGFCRFTLEQHFPWIQPIQPSSIFSEPQTIQQHILDYLRKNLWDTVLSPKQYAFLSYHHRATTQQTRHLIERLLQDYTSTPNLALSPLSITLQKLKAWVSRYQHLAPLSLEEMQAFSLRFKQSDLSIERELPAFVQQFETNPYSLDMLFFPGMVQKFQEENRNKKKLSAPASPLDPFFQDWIQLAHPFCQKEPIFHTLLKSVQQHLKTHCAQSYSHDESIATLESLLAHNDTVVSQLRKQFQLVLIDEFQDTDKRQWQIFSKLFASPDYSGSLFLIGDPKQSIYEWRNADLPTYLQAKHSFPKEAQLILDTNYRSTPELMQALNHLFSLPTPFLETPQNILYHPLHSKGSAEISYSEFSPIHFFSSEDIQEETLWISKTASYLRSAYSIPFGNMAVLVQDYPQALKLITHSTIPMAYCKEKRIFDRTESPYLLILLLEALLYPENQQKIQAILMSRLFQLSSTEIHQHLKTFSSLFFTLNRHLYHYSLLATFYKLMGENVLSQTIGETLLQTPLGDIIFQELEALCLYLDKTTENPHHKLLHLINILITGKYDEELSFSSQSNDENMIKITTVHSSKGLEYDVVFCSCLNKAKEKTPSVHMREMYVACTRAKKFLFIPFSPIEKRSLSTKKLSALANYANVTKHHSVPHLVETLTSSSPELFSSSFQPPESSLTPDRERLPQQTYFSLPHLPSRTIHSFSSTVENLHFSEPIQELSPSLLFPGGSLTGTLIHKLLESLAGNFAACFEEIFNKAQTLLKNTPLEGYESIIAEKICTVFSTTLPFSSGSFALRNVHPHNIRAEETFLLQEEGELWQGIVDLFFEHKDRFFIIDWKTSFLGDETSCYSPDQLHLYIQRQGLDRQERLYRKAAKRFLHQFNSLLQVEMAFVFIRGLDDKGNGFLQPGR
What is the function of this protein?
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair.  Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity.  Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction.  Cuts ssDNA a few nucleotides 3' to the Chi site.  The properties and activities of the enzyme are changed at Chi.  The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair.  Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination.  In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
What are the official names of this protein?
RecBCD enzyme subunit RecB, Exonuclease V subunit RecB, ExoV subunit RecB, Helicase/nuclease RecBCD subunit RecB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
Protein: LEPA_UREP2
Sequence: MDKKFIRNFSIIAHIDHGKSTLSDRIIEFTNTLSKREMTNQILDSMDIERERGITIKLNAVQIKYHAKDKHEYLIHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLSNVYLALENNLEIVPTINKIDLPSADPNRVKKEIEDVIGLDTADVPLISAKTGLNIQDVLEAIIKHVPPPLDAKDDAKLQALIFDSFYDSYKGVVCLVRVKQGTIKVGDKIRMMANNKDYIVSELGIRTPKIVNKTELVAGEVGWVAAAIKTVKDINVGDTITHTNNPADKPLPGYKKILPMVYCGLYPIDTSQYDDLKEAMAKISLSDAALTYEYETSQALGFGIRCGFLGLLHMDVIRERIAREFNIELILTAPSVIYKIELTNNQEISIDSPAKMPEPTSIKLIKEPFVKLAIITPDNYVGAIMELCQSRRGIYDDLEVIDGTRRKLIYKMPLAEIMYSFFDSLKSITKGYATMDYELIGYQAEKLVKIDIMLNGNKVDALSIIAHRDFAYGKSKIICERLKEVIPKHQFEIPIQASIGSKIIARETIKAVRKDVIAKCYGGDVSRKKKLLEQQKEGKKRLKAIGNVDVPQDAFVKVLSEN
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SLX4_BLAGS
Sequence: MDNAAIASQSNTPPSNGRSSARFVTPISVHSSPISAEVIEPSSPFSPPSPSTLLTSLSKSPSHKISNLQMDGAKTTCLEVIQNSSLVVDSPKRQDKSITGSKAKPASTMRHGQRTASHKMATQTEIQTVDGDRLIVSPKTRKKKAATAKRTRKQDGVAERRLHGHVSKVKSPGDLKLDAKIPPSKPCDNKAPSVGDNTDNELERQTGGLQLEKATKRRLDWTPTKEGPIPMVDLAEVHSSSCGKSVIRTHSAGTLLSNYGFSGVVNTSLAPMPETCDNGPTTKRLMELQNFYSASGIQTPTESRPATNDSQSISSKQQRVKVKKPQKAKLTTLTSYVTAKYSVVDQTADLDRIETVNSGKNKKMGVTKRTSGTERANAARGKSDTLKNGNGPPVFKVVPPLEAFKSFDGQELLFGTSSQLEHGHSEDQDEEIQHTADSINKSNVVPRPAVSKGLGSSLFRLSSSKNLWSASSRDLTGAVLQVDEIDLSERSIEVSTPAAKYKRKTGIRDLSGQNVIDVEKDTRTLAANIDTRELDNMNEPSLAEDDLVYRENLESTNAKLNSQTPANISEAMLERPPPDKPIFGGFTTSELAKQVAAYGFKPIKSRDKMISLLEKCWENQSKSSKLEPKPNQRNHKSQGDDLAERQLLGLKPRSDSISFVITRSPKKRLAKTSVKSQEPKSFSLSNEGPRITSKLPMKRFVSPCAILIDDDQSSDSVGEALPLSPSHSSNGNGTLHHPQDCDEIHAPTTQMAIRSAKSSISVSSTTNLPSLSSQITKAVQSQPRIRAFKGLKQPTWYEKILMYDPIQLEDLAAWLNTGGFGLIGEDREVGAGVVREWCESKGICCVWKKQASAKSH
What is the function of this protein?
Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX4.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PIP_HYLAG
Sequence: MRLLQLLFRASPATLLLVLCLQLGANKAQDNTRKIIIKDFDIPKSVRPNEEVTATLAVRTELKECMVVKTYLISSVPLEGGFNYKYTACLCNNNPKTFYWDFYTNRTVQIAAVVDVIRELGICPDDAAVIPIKSNRFYTTETLKVE
What are the official names of this protein?
Prolactin-inducible protein homolog, Prolactin-induced protein.
What is the protein family that this protein belongs to?
Belongs to the PIP family.
What are the subcellular locations of this protein?
Secreted.
Protein: DINI_SERMA
Sequence: MRVEVTIDKTRPLPAGAIEALTGELGKRVNRQFPDAVVHVRYAGANGLSVLGGAKTDRDLIEEILQETWESADEWFSAE
What is the function of this protein?
Involved in SOS regulation.  Inhibits RecA by preventing RecA to bind ssDNA.  Can displace ssDNA from RecA.  Inhibits NucA transcription.
What are the official names of this protein?
DNA damage-inducible protein I.
What is the protein family that this protein belongs to?
Belongs to the DinI family.
Protein: SIK1_RAT
Sequence: MVIMSEFSAVPTGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHNHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQADPTLLQQDDPAFSMQGYTSNLGDYNEQVLGIMQALGIDRQRTVESLQNSSYNHFAAIYYLLLERLREHRSTQPSSRATPAPARQPQLRNSDLSSLEVPQEILPCDPFRPSLLCPQPQALAQSVLQAEIDCDLHSSLQPLFFPLDTNCSGVFRHRSISPSSLLDTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLAEVSTHFSPLNPPCIIVSSSAAVSPSEGTSSDSCLPFSASEGPAGLGGGLATPGLLGTSSPVRLASPFLGSQSATPVLQSQAGLGATVLPPVSFQEGRRASDTSLTQGLKAFRQQLRKNARTKGFLGLNKIKGLARQVCQSSIRGSRGGMSTFHTPAPSSGLQGCTASSREGRSLLEEVLHQQRLLQLQHHSAVSSDYQQAPQLSPVPYVLTPCDGLLVSGIPLLPTPLLQPGMSPVASAAQLLDAHLHISAGPVALPTGPLPQCLTRLSPSCDPAGLPQGDCEMEDLTSGQRGTFVLVQ
What is the function of this protein?
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression.  Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2.  Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis.  Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1.  Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes.  Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2.  Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity.  Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1.  In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase SIK1, Protein kinase KID2, Salt-inducible kinase 1, SIK-1, Serine/threonine-protein kinase SNF1-like kinase 1, Serine/threonine-protein kinase SNF1LK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ.
Protein: MQO_BACC7
Sequence: MSNMQQKTDVILIGAGIMSATLGSLLKELAPEWEIKVFEKLASAGEESSNEWNNAGTGHSALCELNYTSEKSDGSIDISKAVKVNEQFQLSRQFWAYLVKSKLIRNPQDFIMPLPHMSLVQGEKNVQFLKNRFEALSKNPLFQGMEFSDSPETLKKWLPLIMEGRTSNEPMAATKIDSGTDVNFGALTRMLFDYLKTKNVELNYKHSVENIKRTKNGLWEVKVHDMNSGKIEHHTAKFVFIGGGGGSLPLLQKTGIPESKHIGGFPVSGLFMVCKNQKVVEQHHAKVYGKAKVGAPPMSVPHLDTRYIDNKKALLFGPFAGFSPKFLKTGSNLDLIGSVKPNNVLTMLAAGVKEMGLTKYLIQQVMLSHEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTDAGGKGTLQFGTEVVSAADGSIAALLGASPGASTAVHVMLEVLEKCFPSRMVEWEGKIKEMIPSYGISLTENPRLFQDLHTSTGRTLGLNEKETVHN
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: RUVA_HELPJ
Sequence: MIVGLIGVVEKISALEAHIEVQGVVYGVQVSMRTAALLQTGQKARLKILQVIKEDAHLLYGFLEESEKILFERLLKINGVGGRIALAILSSFSPNEFENIIATKEVKRLQQVPGIGKKLADKIMVDLIGFFIQDENRPARNEVFLALESLGFKSAEINPVLKTLKPHLSIEAAIKEALQQLRS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: CTSL2_XENTR
Sequence: MRLRTRKGSPRSSHGAAGRTARCKRKHSEEDEEEESQLIEEDKLPKQETGLLSTIKNFIKGSTNKEDRENPAKRSRVERDLDNNLITSTPRTGDKPSKPIARVRRKSQVNGEATGYEVSQHMKQNGKLEDLPSTTSPPRTTLLGTIFSPVFNFFSPANKNGTSGSDSPGQAVEAEEIVKQLDMEKVDEFSTSTATNGASYPSLAAPVRSTASSWLEGTEDSPEREIPPLTAPVSPESGYSSAHAEAAYEEDWEVFDPYYFIKHVPPLTEEQLNRKPALPLKTRSTPEFSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQIYEIILFTASKKVYADKLLNILDPKKRLVRHRLFREHCVCVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDKELLKLVPFLENLVELNEDVRPHIRDRFRLHDCLPPD
What is the function of this protein?
Probable phosphatase.
What are the official names of this protein?
CTD small phosphatase-like protein 2, CTDSP-like 2.
What is the protein family that this protein belongs to?
Belongs to the CTDSPL2 family.
Protein: MIAA_ECOLI
Sequence: MSDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSALIYKGMDIGTAKPNAEELLAAPHRLLDIRDPSQAYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEVDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQARDEVLQVVGAIAG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.