PharMolix/UniProtQA huggingface dataset:
Protein: SCAP_RAT
Sequence: MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD
What is the function of this protein?
Escort protein required for cholesterol as well as lipid homeostasis.  Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2.  At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum.  Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.  Binds cholesterol via its SSD domain.
What are the official names of this protein?
Sterol regulatory element-binding protein cleavage-activating protein, SCAP, SREBP cleavage-activating protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SCAP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. Requires the presence of SPRING for proper localization to endoplasmic reticulum.
Protein: IPI3_DEBHA
Sequence: MDESVFYISEGDPADKHSQESFGHSSSVHSSQQHAGFRQADCPQNGACLSGVGTGERLFVASPNKALINVYSWGKESPDQRIPIPEQLSCLTLCKHPRIKVSEGRQSDERNLPSFRTPWLLAGGSKTGKIYVWELASGNLLCVKEAHYQAITAIKFSQCGTFLVSGSSDARCMVWRTSDLISVYNKDEESSINIKPFASFTDHSLPITDLAISEAGIISDLRLYTVSRDSTLRIYDIMTKSLLTTFVLPSGIECVTKDPANRACYVGLSNGLIRTVPLYQINPNTSVLESIGGRGKIVTLDTDPNLLSTFVHHQQRLSTEPLHKTLNKKTTTEEKPILVTRLSITMDGSNLISGDSAGRVYVSDIVSRQVVKTFAPCKSSISYIQVNACAAEKVSVSNTSSNNNDKRHRLIPQFKRVLANPDPLEHQLYMEIPKQQEDEEDFESWLARKSQEELEFRNLTHINSSVTVTGAAPTTNDSTVKELEEKLAKVSKAYTDLRGKHEELYEEHNRLLSDS
What is the function of this protein?
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
What are the official names of this protein?
Pre-rRNA-processing protein IPI3.
What is the protein family that this protein belongs to?
Belongs to the WD repeat IPI3/WDR18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFP_BURM7
Sequence: MKTAQELRVGNVVMIGNDAWVVSKTEYNKSGRNAAVVKMKLKNLLNGGGQESVYKADDKFEVVVLDRKEVTYSYFADPMYVFMDADYNQYEVEAEMMGDALNYLEDGMACEVVFYNEKAISVELPTILVREITYTEPAVKGDTSSGKVLKNAKLATGFELQVPLFCNTGDKIEIDTRTNEYRSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUZP1_HUMAN
Sequence: MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSDDDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKSVRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEKQKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSSPFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIRWKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDFSELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNHSASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN
What are the official names of this protein?
Leucine zipper protein 1.
What are the subcellular locations of this protein?
Nucleus. Note=Also detected in soma and dendrites of neurons.
Protein: ARLY_BIFLS
Sequence: MTENNEHLALWGGRFTSGPSPELARLSKSTQFDWRLADDDIAGSRAHARALGRAGLLTADELQRMEDALDTLQRHVDDGSFAPIEDDEDEATALERGLIDIAGDELGGKLRAGRSRNDQIACLIRMWLRRHSRAIAGLLLDLVNALIEQSEKAGRTVMPGRTHMQHAQPVLLAHQLMAHAWPLIRDVQRLIDWDKRINASPYGSGALAGNTLGLDPEAVARELGFSRVTDNSIDGTAARDLVAEFAFVAAMTGVDISRLSEEIIIWNTQEFAFVKLDDGYSTGSSIMPQKKNPDIAELARGKSGRLIGDLTGLLSTLKGLPTAYARDLQEDKEAVFDQVDTLEVLLPAFTGMVKTMHFDGDRLEEEAPTGFALATDIAEWLVKNGVPFRHAHELSGACVKLAEGRGQELWDLTDNDFIETFAAFLPADKAPGVREVLSSHGSVDSRNGKGGTAYGRVREQIADAKAEVEELKLFPASTSDGSAYKAPGTF
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGRB_SHIBS
Sequence: MKKFRWVVLVVVVLACLLLWAQVFNMMCDQDVQFFSGICAINQFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NR2C1_BOVIN
Sequence: MASIEEIAHQIIEQQMGEIVTEQPTGQKIQIVTALDHNTQGKQFILTNHDGSTPNKVILARQDSTPGKVFFTTPDAAGVNQLFFTTPDLSTQQLQFLTDNSSSEQGPNKVFDLCVVCGDKASGRHYGEVTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETARSAGLLDSGMFVNIHQSGIKTESTMLMTPDKAVSCQGDLSTLASVVTSLANLGKTKDPAPNSNEVSMIESLSNGDTSYTSVCEFHQEMQTNGDVSRAFDTLAKALNPGESTACQSSGEGMEGNVHLIAGDSSINYIEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHSSLQQDKISAERRKLLMEHIFKLQEFCNSMVKLCIDGYEYAYLKAIVLFSPDHPGLENMEQIEKFQEKAYVEFQDYITKTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHILKMEPADYNSQIIGHSI
What is the function of this protein?
Orphan nuclear receptor.  Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism.  Primarily repressor of a broad range of genes including ESR1 and RARB.  Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription.  Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity).  Also activator of OCT4 gene expression.  Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation.  Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity).
What are the official names of this protein?
Nuclear receptor subfamily 2 group C member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Note=Recruited by HDAC3, after all- trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation.
Protein: RLMN_STRAW
Sequence: MPKPGELTFVAPRGAKKPPRHLADLSPAERKEAVAAIGEKPFRAKQLSQHYFARYAHDPEQWTDIPAGSRAKLQEALLPDLMTVVRHLSTDQDTTRKTLWRLFDGTLVESVLMRYPDRVTMCISSQAGCGMNCPFCATGQAGLDRNLSTGEIVHQIVDGMRALRDGEIPGGPARLSNIVFMGMGEPLANYKRVVGAIRALTDPEPDGLGLSQRGITVSTVGLVPAIHRFADEGFKCRLAISLHAPDDELRDTLVPVNTRWKVREVLDAGWEYAARSGRRLSIEYALIRDINDQAWRGDRLGRMLKGRPVHVNLIPLNPTPGSKWTASRPEDEKAFVEAIAAHGVPVTVRDTRGQEIDGACGQLAATER
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_PARP8
Sequence: MSVADIKKGAEQKMQRSLDAFKNDLSKIRTGRAHTGLLDHIQVDYYGSPVPISQVANLTLVDARTIGVQPWEKKMVAVVEKAIRESDLGLNPASHGDVIRVPMPPLTEERRKELTKVVKSEGETAKVAVRNLRRDANEQLKKLVKDKEISEDDERRAGDDVQKLTDKFVAEIDKLVQTKEGEIMTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUS3_ARATH
Sequence: MREEQVSDCGSITLEEWNGSSSTKLFKTATITASSSLSIQRSANRFNHVWRRVLQAFVPEGFPGSVTPDYVGFQLWDTLQGLSTYTKMMLSTQALLSAIGVGEKSATVIGATFQWFLRDFTGMLGGILFTFYQGSNLDSNAKMWRLVADLMNDIGMLMDLLSPLFPSAFIVVVCLGSLSRSFTGVASGATRAALTQHFALQDNAADISAKEGSQETMATMMGMSLGMLLARFTSGNPMAIWLSFLSLTVFHMYANYRAVRCLVLNSLNFERSSILLTHFIQTGQVLSPEQVSSMEGVLPLWATSLRSTNSKPLHKRVQLGVRVSSLPRLDMLQLLNGVGASSYKNAKYLLAHIKGNVSVILHKDSKPADVLKSYIHAIVLANLMEKSTSFYSEGEAWIDKHYDELLHKLRSGGWKTERLLSPSITWRANWISHTSAAKFD
What are the official names of this protein?
Protein root UVB sensitive 3.
What is the protein family that this protein belongs to?
Belongs to the RUS1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PSIP1_CHICK
Sequence: MSRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKMPIFFFGTHETAFLGPKDIFPYSENKDKYGKPNKRKGFNEGLWEIDNNPKVKFSHQPSHPAVNTSIKETIQESSPEAAEGSEEKSGAKRRKPSIPKLPPKGDNNSPAEAEAEEKEMHSTKEDEEPSEKNSKEGVVKTNDASIPKVARRGRKRKAEKQAESEEAAVVATAAVVAAAAAPVTVSPKVSPKRGRPAVSEVKVPKPRGRPKLVKPSCLSESDPVNEEEKAKKKGPDEKPKKQGKKDEEGQKEEEKPKKEYDKKDGKKEAEPKRKNAAKLGSASASDSEDEGGEEEGDKKKKGGRSFQSTHRRNIMRGQHEKEVTERKRKQEEQGESELQNKEEGKKTEVKKMEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVSMQQAQKHTEMILTLKKIRKFKVSQVIMEKSTMLYNKFKTMFLVGEGDSVLSQVLNKSLAEQKQHEEANKTKEQWKKGTNKKNEKEKDQTGSKIVNGGSETQDTNQSQHNGENAEEKDKLEVASKKKTCGEESELEKPAKESAFENK
What is the function of this protein?
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis.  Involved in particular in lens epithelial cell gene regulation and stress responses.  May play an important role in lens epithelial to fiber cell terminal differentiation.  May play a protective role during stress-induced apoptosis (By similarity).
What are the official names of this protein?
Lens epithelium-derived growth factor.
What is the protein family that this protein belongs to?
Belongs to the HDGF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KCNA4_MUSPF
Sequence: MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGGSHHHHQSRGACTSHDPQGGRGSRRRRRQRPEKKKAHHRQSSFPHCSDLMPSGSEEKILRELSEEEEEEEDEEEEEEEGRFYYSEDDHGDECSYTDLLPQDDGGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLIMALSAGGHSGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEGKCQGKGDDSETDKNNCSNAKAVETDV
What is the function of this protein?
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.  Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient.  The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:7943383).  Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity).  Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation.  In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member.  Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:7943383).  Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity).
What are the official names of this protein?
Potassium voltage-gated channel subfamily A member 4, FK1, Voltage-gated potassium channel subunit Kv1.4.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon.
Protein: O16C_CONMA
Sequence: MKLTCVMIVAVLFLTTWTFVTADDSRYGLKNLFPKARHEMKNPEASKLNKRDECYPPGTFCGIKPGLCCSAICLSFVCISFDF
What is the function of this protein?
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.
What are the official names of this protein?
Delta-conotoxin-like MVIC, Delta-MVIC.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PHB1_MOUSE
Sequence: MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ
What is the function of this protein?
(Microbial infection) In neuronal cells, cell surface-expressed PHB1 is involved in human enterovirus 71/EV-71 entry into neuronal cells specifically, while membrane-bound mitochondrial PHB1 associates with the virus replication complex and facilitates viral replication (PubMed:29324904).  May serve as a receptor for EV71 (PubMed:29324904).
What are the official names of this protein?
Prohibitin 1, B-cell receptor-associated protein 32, BAP 32.
What is the protein family that this protein belongs to?
Belongs to the prohibitin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Nucleus. Cell membrane. Cytoplasm.
Protein: KTNA1_XENLA
Sequence: MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTFLQQKWQQVWQEINMECKHVKDIMSTLEGFKLDSSPVKTTQHEFPSHDGEVWSLPVPVERRPSPGPRKRQSVQCNDNKSHNNRFSAAAKGPNLPSARNANNVKMKPVRAREKKDALIKNKSSADVSETEVKRFDGSGYDKDLIEALERDIISQNPNIRWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNISSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENEDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRINLKELELADDVNIECIAENMDGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSRDDMHMPTTMEDFEMALKKVSKSVSASDIEKYEKWIFEFG
What is the function of this protein?
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner.  Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.  In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux.
What are the official names of this protein?
Katanin p60 ATPase-containing subunit A1, Katanin p60 subunit A1, p60 katanin.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with katnb1.
Protein: KCY_STRPZ
Sequence: MKAIKIAIDGPASSGKSTVAKIIAKNLGYTYLDTGAMYRSATYIALTHGYTGKEVALILEELEKNPISFKKAKDGSQLVFLGDEDVTLAIRQNDVTNNVSWVSALPEIREELVHQQRRIAQAGGIIMDGRDIGTVVLPDAELKIFLVASVEERAERRYKENLEKGIESDFETLKEEIAARDYKDSHRKVSPLKAAEDALIFDTTGVSIDGVVQFIQEKAEKIVDMS
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNGF_ECO57
Sequence: MRNRTLADLDRVVALGGGHGLGRVLSSLSSLGSRLTGIVTTTDNGGSTGRIRRSEGGIAWGDMRNCLNQLITEPSVASAMFEYRFGGNGELSGHNLGNLMLKALDHLSVRPLEAINLIRNLLKVDAHLIPMSEHPVDLMAIDDQGHEVYGEVNIDQLTTPIQELLLTPNVPATREAVHAINEADLIIIGPGSFYTSLMPILLLKEIAQALRRTPAPMVYIGNLGRELSLPAANLKLESKLAIMEQYVGKKVIDAVIVGPKVDVSAVKERIVIQEVLEASDIPYRHDRQLLHSALEKALQALG
What is the function of this protein?
Required for morphogenesis under gluconeogenic growth conditions.
What are the official names of this protein?
Putative gluconeogenesis factor.
What is the protein family that this protein belongs to?
Belongs to the gluconeogenesis factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSRP1_CAEBR
Sequence: MSAPPKRFGLIVKQKEEPKRAPVRVSSVFGDDDDDEAPATATNTSSASVIRIQKAAEREHQKAEAEDPTIFDYDGNYDEIQAIKNEKKEEARKADKNKESKYAEAIIKAHARRQLEQFSREERQQIKEREKEAGEFDDKEVFVTGAYRKQQEEVKKYREQEAEEAAFNDMTSVQKQKMWEMGMGRTLLNDLARDPTAIKQRKMEKKNVRKREDSGDEEEQKEDVKKKEEPKKKSIYDTDSEDDEKKSKAPEAPKKNFEGELKAGLNLVTKKATTHAERIRQRNFTPTPPSSDDEAPKPAPRAVGDHRRSTSPRRSRDHAQRNQREKTKSKSPEPPKAQKTSLKDKLKPKRIDKAARLDGLKAILAQRNTEKDIEEARQRYFERREQGLVVPPL
What are the official names of this protein?
Nuclear speckle splicing regulatory protein 1 homolog, Coiled-coil domain-containing protein 55 homolog.
What is the protein family that this protein belongs to?
Belongs to the NSRP1 family.
Protein: MURI_LEIXX
Sequence: MTDAPIGIFDSGVGGLTVARAIRDQLPNESILYVGDTTHSPYGPKPIADVRRYSLEVLDLLVEQGVKLLVIACNTASSAVLRDARERYAVPVVEVIQPAVRRAVAATRTGRVGVIGTVGTIASRAYEDAFAAAPDLRLFPRACPRFVEFVETGVTSGDEVLRVAAEYLQPLRDADVDTLVLGCTHYPFLEGAISYVMGEGVSLVSSDIETAKDVYRILVSGGFERHDSAPPTVRYEATGLDAEHFLRLAHRFIGPEVSQVDLVQTGVIDLSL
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: CRBL2_DANRE
Sequence: MDDSKIVAGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSKERAICALREELDMYKQWCLAMDQGKIPSEIKALLTGDEQKTPQSCSNKTTKNSKYSSSSGI
What is the function of this protein?
Probable regulator of creb1 transcriptional activity which is involved in adipose cells differentiation.  May also play a regulatory role in the cell cycle (By similarity).
What are the official names of this protein?
cAMP-responsive element-binding protein-like 2.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SEPF_STRPQ
Sequence: MAFKDTFNKMISYFDTDEVNEVEEDVAASTDNVIPRSQQSVRASSHPKQEPRNNHVQQDHQARSQEQTRSQMHPKHGTSERYYQQSQPKEGHEMVDRRKRMSTSGIANRREQYQQSTCSDQTTIALKYPRKYEDAQEIVDLLIVNECVLIDFQFMLDAQARRCLDFIDGASKVLYGSLQKVGSSMYLLAPSNVSVNIEEMTIPHTTQDIGFDFDMKRR
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RS16_STRPS
Sequence: MAVKIRLTRMGSKKKPFYRINVADSRSPRDGRFIETVGTYNPLVAENQVTLKEDRVLAWLANGAQPSDTVRNILSKEGVLKKSTILNSQNKFKVG
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: YFEO_ECOUT
Sequence: MLHPRARTMLLLSLPAVAIGIASSLILIMVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSNEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVFVLGIGGLILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRQKQQPPHDNV
What are the official names of this protein?
Putative ion-transport protein YfeO.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBIE_PARXL
Sequence: MSKTHFGFQSVDEQDKAQKVAGVFHSVAANYDLMNDLMSGGLHRAWKMFTIAQANVRPGYKVLDIAGGTGDLSKAFAKQAGETGEVWHTDINESMLRVGRDRLLDKGVITPALLCDAEKIPFPDNYFDVVTVAFGLRNMTHKDIALAEMRRVLKPAGRLLVLEFSKVWDPLKKVYDVYSFKVLPWLGEHFAKDAGSYQYLAESIRMHPDQETLKTMMEQAGLDGVKYYNLSAGVVALHVGTKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.