PharMolix/UniProtQA huggingface dataset:
Protein: TOP3_VIBCH
Sequence: MTRLFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKKWNMADLPIIPEQWQLRPRKSSSQQLTVVRKLLKEATQIIHAGDPDREGQLLVDEVIDYCKVPKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSALARSRADWLYGMNMSRAYTLLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFTLDALIPYQNGTEYFDIRARWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESEQDQTKQAAPLPYSLSALQIDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPKEHLAQAPDVVAAIANNAQEMVTAVNDADLSLRSKAWNDSKVDAHHAIIPTPKKASVNALSGHEMKVYQLIARQYLMQFYPAAIYAEAKLVFNIAGGIFIAKGRQLLSAGWKVLTGQQDEQEECVDKVPPLPVGIVLQCREGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKILRETDGLGTEATRAGILDTLFKRGLLQRDNKLIKSTPAGRGLIHALPSEATYPDMTAHWEHQLQAIAEKGQAYQPFMQTLQGRLEQLIEQVQVAPVPVSLQALPAVSKPAFKRTRRAPKSKARTYKA
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 3, DNA topoisomerase III.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: HIS2_BACC7
Sequence: MKNAFTLLFETIKERKRNPLSESYTNYLFSKGEDKILKKIGEECTEVIIASKNNDNEELVKEMVDVMYHCFVLLAEKNISLEDIMEEVTERNGKLSRVGDRREIDTL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEF_SIVSP
Sequence: MGGVTSKKQRRRGGNLYERLLQARGETYGRLWEGLEGEYSQSQDASGKGLSSLSCEPQKYCEGQFMNTPWRNPATERAKLDYRQQNMDDVDSADLVGCPVSPRVPVRIMTYKLAIDMSHFIKEKGGLEGIYYSDRRHKILDLYLEKEEGIIPDWQNYTAGPGIRYPMFFGWLWKLVPVNVSDEAQEDETHYLMHPAQTSQWDDPWGEVLAWKFDPKLAYNYKAFVEHPEEFGSQSGLSKEEVQRRLTARGLLKMADKKKTS
What is the function of this protein?
Interferes with TCR signaling from the cell membrane.  Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Associates with the inner plasma membrane through its N-terminal domain.
Protein: RL4_COLP3
Sequence: MELSLKDASGALEVSEATFGREFNEALVHQVVVAYAAGARQGTRAQKTRSEVSGGGAKPWRQKGTGRARAGTTRGPIWRTGGVTFAAKPQDHSQKVNRKMYRGAIASILSELVRQERLVVVENFSVETPKTKELVAKLKGLELKDVLIVTKEVDENLFLSARNLYKVDVRDVAAIDPVSLVGFEKVLITADAVKEIEGILA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MNTP_PSYA2
Sequence: MDIEMIEVILLAIALAMDAFAVSIGLGAKSQKQSSAYVLRLAVYAALYFGIAQGVMPLIGYLLGAVLLGWLATAAPWIGGGILIVLGAKMLYEAFNGEIEAVLEDGFDENIRKKINHRMMFTLAIATSIDAMAAGFTLNLLALNAWLACLIIAIVTAGFGFFGIYLGKSSGTWLEDKAEILGGLVLIAIGVKVMLFS
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEUD_FRASN
Sequence: MEAFTIHTGRAVPLRRSDVDTDQIIPSEWLKRIERTGFGAGLFSEWRADPSFVLNDPAHAGASILLAGPDFGTGSSREHAVWALQDYGFRAVLSPRFADIFRGNALGNGLLPVVLPADTVEALTAAVEADPTTEITVDLVAREVRGAGQVAGFELDDFTRWRLMEGLDDVGLTLRHEQDITVFEASRPGWLPTTA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: CRT10_YEAST
Sequence: MPPQIPNENDDLFTRWLKSRAIIQRAVSTRECFDSEVFLASGGWNITNEIITLKKYYQLKWPNSSCNSFHPKTVEFIKERLHNLEEHDSSWKIPNPAYSFKKAFLEDTKSAFSNLEPVWGPSRLLNPAELLLPQDEKLLVQEIPLEFAPFQYTNRFAYGGLQFKNNLFVTYGSYSFLAAGQCVEVHNFDILLNVSSLEICHALLPVIIPDDGDVRNFRNSSYVKFKDTQFNSIPELCSINFMKICNFMHQDFLLACGDNGIVYIWEINKVIKIFNKFTSDILGGKDNSRERYINVDPYMVLRVEESCWSVDVIDINGIIYIAVGHNKPGVTVFAFDKDVKKERRYIRPLDLPSSHNVPCVNFVPNSKDSVGYITLSYCSIFGNVVTVKLKEHDCTILTSFLDTQFFGDDLWTITPLTKKDFAKVDNFELLNLNYQDGFKESMLYSICRDDFLLGYYCDNAYLSGNFGIGTLLNQFQVPVTDLRLTSSAGIPDEVIPLRFTSFDRNYTTTGSIKYEYSREDFALILHAGDLDDMNDAVTKNTSCEQHLHQWTFWEDSGYKHYRATERGFSKYKDIINTFPQLITPSGRNKTSQYQNTSGRKICEPSTYKLTDLENDIEDISREFNRSIRNLKMDKQRQLRTSKEFKSLSSVNHIPNIESGNFLWYNTDAAADWRTLFGKDLNTVLKDPEICSLQLNSTEEDDVNSDPENEESGSSLTSFQRRYRDTEQRAHLKSESQKSWGFHNYVRNVKRLLESAVPGSEDSPLGYQLSEMHDEFFFLTTAHRLVLMKANPLIIISATHHEIFPLDGVVTCASKSLLQALNRINFVCHIKELNCIAVASQLGLISLLRLTEYRGIYSFRQEYILGWEVQDPVNPSPECRCNRNLFDAPMYGADGESSDTYCGVCDVYFPMGDICGLDYTYASDSEELKRKGYATLYVASRGSLRAFKITTEHGTTQQ
What is the function of this protein?
Substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-CRT10).  RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of RNR genes encoding ribonucleotide reductases.
What are the official names of this protein?
Protein CRT10, Constitutive RNR transcription regulator 10.
Protein: KDPC_MYCTO
Sequence: MRRQLLPALTMLLVFTVITGIVYPLAVTGVGQLFFGDQANGALLERDGQVIGSAHIGQQFTAAKYFHPRPSSAGDGYDAAASSGSNLGPTNEKLLAAVAERVTAYRKENNLPADTLVPVDAVTGSGSGLDPAISVVNAKLQAPRVAQARNISIRQVERLIEDHTDARGLGFLGERAVNVLRLNLALDRL
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MCES_NEOFI
Sequence: MYDPARDSWEERDGDEARSLRGRLASDQPHAGFSSSEQIYGASGENNNTTDLQHPGPDPKTTASAKVLYAESPPAQSTTQTPPSISTHVQSPVNPAAQEASNTQSLTSAAQNQSNKSTTTMDNTSGSATPKPRADPSDKSNRPDQVASPTDQNGSQGDKKRKVPAEENASEKSQPTPDRPVSKRKRMEERHQKLRKRGRTPPSAYSRRDADETASAADRNGPTYRSTSPLPPPRSPTPEDQPRQRKRPGGGARMGLVDRETLRRRQEERERAQVEEAMRASQGRGLADVVRQHYNAVPQRGREWRKTESKIKGLRSFNNWIKSTLIQKFSPDEEFLARFNGTKDWAEDGGVPPVEEKRLLVIDLGCGKGGDLLKWQLAPQPVDLYVGLDPAEVSIVQARERYNGMKSGRGNRGRRNPIFHAEFQPKDCFGEWLGDVDIVQQVGIDPNVGPGGSVMSSRWGGGGFDVVASMFTIHYAFESEEKARQMLRNVAGCLKKGGRFLGVCPNSDVISARVSEINAKKKERQSQAKKEKTDEAPEDGEVEEDDGKVEWGNQIYRVRFPVTTPEDGIFRPPFGWKYSYFMEEAVEEVPEYVVPWEAFRALTEDYNLELQYRKPFLDIWRDEKDDPELGPLSERMGVRDRATGELLMTEEEKEAASFYHAFCFYKV
What is the function of this protein?
Responsible for methylating the 5'-cap structure of mRNAs.
What are the official names of this protein?
mRNA cap guanine-N7 methyltransferase, mRNA (guanine-N(7))-methyltransferase, mRNA cap methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIPM_NEIMA
Sequence: MFLFSDGLQSINNNNRRKRIVKNAYIPSRGIRKIPHLSTLLPEFHIYKDGKGAEAVVGWGLRPTTHKARAFATEHQLPFIALEDGFLRSLGLGVSGYPPYSIVYDDIGIYYDTTRPSRLEQLILAADTMPSETLAQARQAMDFILQHHLSKYNHAPELSDDHPLRSPSKSETVLIIDQTFGDMAIQYGGADASTFELMFQTALNENPQADIWVKTHPDVLCGKKQGYLTQLVQQHRVHLLAEDINPISLLQNVDKVYCVTSQMGFEALLCGKPLTTFGLPWYAGWGVSDDRHPKIGSLIQTQRRAPRNLLQLFAAAYLQYSRYLNPNTGEAGSLFDVIDYLATVKRKNDKLRGELYCVGMSLWKRAVAKPFFNVPSCRLKFISSTQKLARVKLSDDARILAWGNGKEAIVRFAEQHHIPLLRMEDGFIRSVGLGSNLVPPLSLVTDDMSIYFNAETPSRLEYILQNQNFDDQDFQTALKLQKMLTENHISKYNVGSSDFTAPSTDKTVILVPGQVEDDASIRYGSPQIYRNLDLLRTVRERNPNAYIIYKPHPDVVSGNRIGHISPDDAARYADQTAEQADILTCLQYADEIHTMTSLTGFEALLRGKKVSCYGLPFYAGWGLTQDLLPIPRRSRRLELWQLVAGTLIYYPDYIHPKTHQAINAETAAQILIRQKNMQKNNNGLHRGCFAKKLGKIKQLYRSFK
What is the function of this protein?
Involved in the phospholipid modification of the capsular polysaccharide, a strong requirement for its translocation to the cell surface.
What are the official names of this protein?
Capsule polysaccharide modification protein LipA.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ICA_MOUSE
Sequence: MRLLICALLCLGTLGLCLALPEKTIRWCVVSDHEATKCSSFRDNMKKVLPAGGPAVTCVRKMSHPECIRDISANKVDAVTVDGALVAEADLPHHSLKPIMAEYYGSKDDPKTHYYVVAMAKKGTGFQLNQLRGKKSCHTGLGWSAGWYVPLSTLLPSGSRETAAATFFSSSCVPCADGKMFPSLCQLCAGKGTDKCACSSREPYFGSWGALKCLQDGTADVSFVKHLTVFEAMPTKADRDQYELLCMDNTRRPVEEYEQCYLARVPSHVVVARSVDGKEDSIQELLRVAQEHFGKDKSSPFQLFGSPHGEDLLFTDAAHGLLRVPRKIDISLYLGYEFLSAFRNLKRGLEDSQRVKWCAVGQQERTKCDQWSAVSGGALACATEETPEDCIAATMKGEADAMSLDGGFAYVAGHCGLVPVLAENYLSTHSSGRLGSKCVNAPLEGYYVVAVVKKSDVGITWKSLQGKKSCHTAVGTSEGWNVPMGLIYNQTGSCKFDAFFSRSCAPGSDPDSPLCALCVGGNNPAHMCAANNAEGYHGSSGALRCLVEKGDVAFMKHPTVLQNTDGKNPEPWAKGLKHEDFELLCLDGTRKPVTEAQSCHLARVPNRAVFSRKDKADFVRRILFNQQELFGRNGFEYMMFQMFESSAKDLLFSDDTECLSNLQNKTTYKTYLGPQYLTLMDNFRQCLSSELLDACTFHKY
What is the function of this protein?
Inhibitor for carbonic anhydrase 2 (CA2).  Does not bind iron ions.
What are the official names of this protein?
Inhibitor of carbonic anhydrase.
What is the protein family that this protein belongs to?
Belongs to the transferrin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HYAL4_MOUSE
Sequence: MQLLPEGQLRLCVFQPVHLTSGLLILFILKSISSLKPARLPVYQRKPFIAAWNAPTDLCLIKYNLTLNLKVFQMVGSPRLKDRGQNVVIFYANRLGYYPWYTSEGVPINGGLPQNTSLQVHLKKAAQDINYYIPSENFSGLAVIDWEYWRPQWARNWNTKDIYRQKSRTLISDMKENISAADIEYSAKATFEKSAKAFMEETIKLGSKSRPKGLWGYYLYPDCHNYNVYATNYTGSCPEEEVLRNNDLSWLWNSSTALYPAVSIRKSFADSENTLHFSRFRVRESLRISTMTSQDYALPVFVYTQLGYKEEPLLFLSKQDLISTIGESAALGAAGIVVWGDMNLTSSEENCTKVNRFVNSDFGSYIINVTRAAEVCSRHLCKNNGRCVRKTWKAAHYLHLNPASYHIEASEDGEFIVRGRASDTDLAVMAENFLCHCYEGYEGADCREMTEASGPSGLSLSSSSVITLCLLVLAGYQSIQL
What is the function of this protein?
Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments.  Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide (By similarity).
What are the official names of this protein?
Hyaluronidase-4, Hyal-4, Chondroitin sulfate endo-beta-N-acetylgalactosaminidase, Chondroitin sulfate hydrolase, CSHY, Hyaluronoglucosaminidase-4.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 56 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ARP5L_MOUSE
Sequence: MARNTLSSRFRRVDIDEFDENKFVDEHEEAAAAAGEPGPDPCEVDGLLRQGDMLRAFHAALRNSPINTKNQAVKERAQGVVLKVLTNFKSSEIEQAVQSLDRNGIDLLMKYIYKGFEKPTENSSAVLLQWHEKALAVGGLGSIIRVLTARKTV
What is the function of this protein?
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 5-like protein, Arp2/3 complex 16 kDa subunit 2, ARC16-2.
What is the protein family that this protein belongs to?
Belongs to the ARPC5 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: UPPP_CAUVN
Sequence: MPDWLIALILGLIEGLTEFIPVSSTGHLLLLGHFLGFHSPGNTFQVLIQLGAILAITGVYFGRLWGLLTTLPTEPGSRRFVIGILLAFLPAVFVGVAAHDFIKTVLYETPALVCSTLIIGGFILLALDRMKLEPRYTDVAEYPLKTAFIIGLFQCLALVPGVSRSGATIAGALLLKCDKRSAAEFSFFLAMPTMAGAFAYDLYKNIDKLSTNDLGLIGIGFLAALVSGVFVVKTVLDFITRHGFAPFAYWRIAVGVVGLALLYIPR
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CATB_CHICK
Sequence: MSWSRSILCLLGAFANARSIPYYPPLSSDLVNHINKLNTTGRAGHNFHNTDMSYVKKLCGTFLGGPKAPERVDFAEDMDLPDTFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAEDLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEGGETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLMYKSGVYQHVSGEQVGGHAIRILGWGVENGTPYWLAANSWNTDWGITGFFKILRGEDHCGIESEIVAGVPRMEQYWTRV
What is the function of this protein?
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins.  Has also been implicated in tumor invasion and metastasis.
What are the official names of this protein?
Cathepsin B, Cathepsin B1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: NANA_SALDC
Sequence: MAKALQGVMAALLTPFDHQQQLDSESLRRLVRFNIGQGIDGLYVGGSTGEAFVQSLAEREQVLEIVAEEAKGKITLIAHVGTVSTAESQQLASAAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVSALKQTSGDLFQMEQIRRAHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVQALREGDVAKAQRLQTECNKVIDLLIKTGVFRGLKTVLHYMDVLSVPLCRKPFAPVDEKYLPALKALAQQLMEEKA
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 60A_DROVI
Sequence: MTASLVVLPSLWLILIIFTAPYTHCTQSGIYIDNGKDQTVMERVLTDDDKLDVSHEILEFLGIAARPLHHKSHGLSLRKSAPKFLLDVYYRITAEEGLAIKNKSDHSRSKRDANESEQNFITDLDKRAIDESDIIMTFLNKRNHNVEEMRHEHGRRLWFDVNNIPTDNYLMMAELRIYQNSNEGKWTTTNKQFTVTVYMLRSGGSAPNMLEPLSSVNTTGDYVGWLELNVTEALHDWRVNSNENHGIYIGAHALNKPEREIKLDDIGLIHRRTKVDDENQPFMIGFFRGPELIKSTSGHSTQKRTKRSTLHQRKKSKSEPVNPFIENSIENTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKRVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGCH
What are the official names of this protein?
Protein 60A, Protein glass bottom boat.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGB_RHILO
Sequence: MTDIAATAEMQAALLSRALPYMQRYEHKTVVVKYGGHAMGDIELGKAFARDIALLKQSGVNPIVVHGGGPQIGAMLTKMGIESKFEGGLRVTDQKTVEIVEMVLAGSINKEIVALINAEGEWAIGLCGKDGNMVFAEKARKTMIDPDSNIERVLDLGFVGEPVEVDRTLLDLLARSEMIPVLAPVAPGRDGHTYNINADTFAGAIAGACKASRLLFLTDVPGVLDKNKKLIDELTVAEAKALIKDGTVSGGMIPKVETCIEAIERGVEGVVILNGKTPHAVLLELFTEHGAGTLIVP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_GRABC
Sequence: MPKLRVTQIASVAGRKPGQKETLIGLGLNKIGRTRVLEDTPSIRGMTRKVAHLIQVEETNEAE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: YXLE_BACSU
Sequence: MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIVCINIIGPILFFTVGRKQR
What is the function of this protein?
Together with YxlD is important for negative regulation of sigma Y activity.
What are the official names of this protein?
Negative regulatory protein YxlE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL2_CLOBM
Sequence: MAVKGFRPTTPTRREMTMCTFEEITTSTPEKSLLVSLKKSGGRNANGKITVRHIGGGAKRKYRIIDFKRNKDNIPAKVVSIEYDPNRTAFIALVVYADGEKRYIIAPVGLKVGDTVVSGPESDIKVGNCLPIRNIPVGTVIHNIELAAGKGAQLVRSAGNSAQLMAKEGDYSQVRLPSGEVRYIRVECRATIGVVSNQTSEIVNIGKAGRKRHMGVRPTVRGSVMNPNDHPHGGGEGRSPIGHPSPRTPWGKPALGYKTRKNKKYSDRFIVKRRHDK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ATPF_SALG2
Sequence: MNLNATILGQAIAFILFVWFCMKYVWPPLMAAIEKRQKEIADGLASAERAHKDLDLAKASATDQLKKAKAEVQVIIEQANKRRAQILDEAKTEAEQERTKIVAQAQAEIEAERKRAREELRKQVAILAVAGAEKIIERSVDEAANSDIVDKLVAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ZN653_HUMAN
Sequence: MAERALEPEAEAEAEAGAGGEAAAEEGAAGRKARGRPRLTESDRARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKPWEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQCEAGHRYFQDLHSPLKPLSDSDPDSDKVGNGLVAGSSDSSSSGSASDSEESPEGQPVKAAAAAAAATPTSPVGSSGLITQEGVHIPFDVHHVESLAEQGTPLCSNPAGNGPEALETVVCVPVPVQVGAGPSALFENVPQEALGEVVASCPMPGMVPGSQVIIIAGPGYDALTAEGIHLNMAAGSGVPGSGLGEEVPCAMMEGVAAYTQTEPEGSQPSTMDATAVAGIETKKEKEDLCLLKKEEKEEPVAPELATTVPESAEPEAEADGEELDGSDMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCDRCGKRFEKLDSVKFHTLKSHPDHKPT
What is the function of this protein?
Transcriptional repressor.  May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.
What are the official names of this protein?
Zinc finger protein 653, 67 kDa zinc finger protein, Zinc finger protein Zip67.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNRK_STRPE
Sequence: MTAEPTVAARPQQIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQAVARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLLACDQDVAFDAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDAVRILTRCAEALEPGGRILIHERDDLHENSFNEQFTELDLRMLVFLGGALRTREKWDGLAASAGLVVEEVRQLPSPTIPYDLSLLVLAPAATGA
What is the function of this protein?
Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers.  In vivo, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 4-O-position of carminomycin to form daunorubicin.  In vitro, it also methylates the anthracyclines rhodomycin D (10-carbomethoxy-13-deoxycarminomycin) and 13-deoxy-carminomycin at the 4-hydroxyl position.  It is quite specific with respect to the length of the carbohydrate chain at the C7 position, but it can accept substrates with bulky substituent at C10 position.
What are the official names of this protein?
Carminomycin 4-O-methyltransferase DnrK, COMT, Anthracycline 4-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: RLME_YERPN
Sequence: MSNKKRSASSSRWLQEHFSDKYVIQAQKKGLRSRAWFKLDEIQQSDKLFKQGMTVVDLGAAPGGWSQYAVTQIGSKGRVIACDLLPMDPIVGVDFLQGDFRDELVLKALLERVGDKKVQVVMCDMAPNMSGTPAVDIPKSMYLVELALDMCRDVLAPGGSFLVKVFQGDGFDEYLREIRSLFTKVKIRKPDASRARSREVYIVATGRKL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_AGRRK
Sequence: MKRRYFGTDGIRGQSNIYPMTPDLAMRVGIAAGTIFHRGSHRHRVVIGKDTRLSGYMLENAMVAGFTAAGVDAFVLGPIPTPAVAMLTRSLRADIGVMISASHNPYEDNGIKLFGPDGYKLSDDLEMKIEDLLEKDMTAHLAKSENIGRAKRVDGVHDRYIEHAKRTLPRDVTLQGLRIAIDCANGAAYKVAPAVLWELGAEVVTIGNEPNGTNINLNCGSTSPVALQKKVDEVRADIGIALDGDADRVIIVDETGTIIDGDQLMAVIAESWAENQSLRGNGIVATVMSNLGLERFLEDRGMALARTAVGDRHVVEHMRQHNFNVGGEQSGHIVLSDYGTTGDGLVAALQILAVVKRTGKPVSEVCRRFEPVPQLLRNVRISGGKPLEDNQVRKAIADAESELARNGRLVIRPSGTEPLIRVMAEGDDRGQIERIVGGLIDVISSVRNAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: TILS_RHOE4
Sequence: MLLPETPALLALRQAVRAWTVAFEPRRRVVVALSGGADSLALTAAAVAETDSVDALIVDHRLQPGSDAVARSAADQALALGCRTATVLTVDVAEGGSLEAAAREARYSALRDARTDLPVLLGHTLDDQAETVLLGLSRGSGGRSIQGMAAFDAPWGRPLLGIRRSVTRAACVDLGITPWEDPHNNNPEFTRVRLRHEALPLLEEILGGGVAEALARTATQLREDGEALDEYAEALLLRAVVDGEVEVDTLAEAPTAIRRRALRAWLLQGGAKALTDKQLRAVDALVIDWRGQGGVAIGGGTPEARLVAARRRGRLILGFEDRRRV
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTP1_TERSU
Sequence: VIFALVLGNASPVQSVAITATAVATAIGAASQIISAGTSLASTILSGLAASGYRVTCAIQVENWTRYPLIYATVQINRNAAVTVSPSSILPGKREGFSVRMPNGLAEGVYGTVSWELLGIKRRFVLMWSAPFNFNHFSNWMGVGLTRPGITKVPSGMTWFNKMYYDKTGRVGNLHFERGEFYYETNPVIYRDSKFEIEGTMTNIHNA
What is the function of this protein?
Pore-forming protein that forms pores of around 1 nm and causes cardiac stimulation and cytolysis.
What are the official names of this protein?
Tereporin-Ts1, Actinoporin-like protein.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Conoidea subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.