PharMolix/UniProtQA huggingface dataset:
Protein: RS21_BACP2
Sequence: MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVKRKKKSEAARKRKF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: PSBL_CHAVU
Sequence: MTQPNPNKQIVELNRTSLFWGLLLIFVLAILFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SYR_CHLSY
Sequence: MRYALERFISDIQAAIVATGKVPADLIEITTPKPNIPADRTFVTFKAAKALGVDPVRLAADLATAIVPPPDSLIGEVTATGAFLNFTLHPQRLAAAVMAEIETYGDAYGSVADGANRTVVIDYSSPNIAKRMHVGHIRSTIIGQALVHIFRALGYRVIGDNHLGDWGTQFGIILAAMQRYGRPQNEGEAAMAELEALYARYNAEMKDNPPLEDEARRWSLALEQGDPTARELWQWCVDLTMRAAQRNYDRLGVRFDYAYGESFYEAMLPGVIEEALQSGAAFRDVDGAVVAELDKLPRFIVQRSDGGTVYITRDIATIKFRLQEFNPSHIIYVVDARQELHFRQLFAIVRAMGYALDVELIHVPFGVITTPDGQPLSTKKGNMVYLESLLDDAVARARALVDAKSPTLSPEERAQIAEAVGIGAVIYNDLYQDPRRNITLDWDRMLSIEGNSAAYLQYSHARCRSILRRAAEEGMLSTEVDPGLLTHPSEQRLVRHLARLPEAVREAGARYAPFVIADWCYTTAREFGIFFEQCPVLRAETPALRAARLQLVSATANALRNGLALLGIQAPERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROL_ECOLI
Sequence: MTQPLFLIGPRGCGKTTVGMALADSLNRRFVDTDQWLQSQLNMTVAEIVEREEWAGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2, Shikimate kinase II, SKII.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_EXISA
Sequence: MAVPFRRTSKTRKRLRRTHFKLNVPGMNECPNCGEMKLSHRVCKSCGHYNGKEVTSK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: UREG_PSEMY
Sequence: MNSQPLRVGIGGPVGSGKTALTLALCRALRERYNIAVVTNDIYTQEDAQFLVRNEALEPERIIGVETGGCPHTAIREDASINLEAVEQLNRRFPGLDLIIVESGGDNLSATFSPELSDLTLYVIDVSAGDKLPRKGGPGICKSDLLVINKVDLAPMVGASLEVMERDTLKMRGDKPFVFSNQKIGQGLDEIIAFIERQGMLTAA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_STAAS
Sequence: MNEEQRKASSVDVLAERDKKAEKDYSKYFEHVYQPPNLKEAKKRGKQEVRYNRDFQIDEKYRGMGNERTFLIKTYGCQMNAHDTEVIAGILEALGYQATTDINTADVILINTCAIRENAENKVFSEIGNLKHLKKERPDILIGVCGCMSQEESVVNKILKSYQNVDMIFGTHNIHHLPEILEEAYLSKAMVVEVWSKEGDVIENLPKVREGNIKAWVNIMYGCDKFCTYCIVPFTRGKERSRRPEDIIDEVRELAREGYKEITLLGQNVNSYGKDLQDIEYDLGDLLQAISKIAIPRVRFTTSHPWDFTDHMIDVISEGGNIVPHIHLPVQSGNNAVLKIMGRKYTRESYLDLVKRIKDRIPNVALTTDIIVGYPNESEEQFEETLTLYDEVGFEHAYTYLYSQRDGTPAAKMKDNVPLNVKKERLQRLNKKVGHYSQIAMSKYEGQTVTVLCEGSSKKDDQVLAGYTDKNKLVNFKAPKEMIGKLVEVRIDEAKQYSLNGSFVKEVEPEMVIQ
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPP2_STRCO
Sequence: MSNRRKNSLYPTLSAELSALMRTGWADTERHDLAPAEQAPYAALRRAALSARFPGERLVVPSGNLKVRSNDDTYPFRSYSGYVHMTGDQARDGALVLEPRPDGGHDAYCYQLPRDSRDDDEFWTGAHAELWTGRRRSLAESERVLGLPCRDVRTAAADLAAVSEVRTRIVRGIDPALEAAVTTDEERDAELEDALSDLRLVKDAWELGELRKAVDSTVRGFTDVVGELSRAVASSERWLEGTFFRRARLEGNAVGYGTICAAGEHATIMHWTDNDGPVRPGDLLLLDAGVETRSLYTADVTRTLPISGTFTPLQREVYDAVYEAQEAGIATVKPGAAYRDFHEAAQRHLAARLVEWGFIEGPAERAYELGLQRRFTMAGTGHMLGLDVHDCARARTEEYVEGVLEPGMCLTVEPGLYFQADDLTVPEEWRGIGVRIEDDLVVTEDGHENLSAGLPRSADEVEAWMARFAG
What are the official names of this protein?
Xaa-Pro aminopeptidase 2, Aminoacylproline aminopeptidase II, Aminopeptidase P II, APP, PEPP II, X-Pro aminopeptidase II, Xaa-Pro aminopeptidase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: NATK_BACSU
Sequence: MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGLYIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQSALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWADQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVGNILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTKNGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK
What is the function of this protein?
Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon.  Potentially phosphorylates NatR.
What are the official names of this protein?
Sensor histidine kinase NatK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NU3M_FASHE
Sequence: MLFFAVLGLLFFLIFFLVLVFHAFLWNLDLGIFSGERSWVSSFECGFLSQRVTENYFSYTYFILLVFFVVFDLEVSLLLNMPLQGVLYKNFFSYLFFLVLLGIGFLVEVRRGYVRWAY
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: GLUQ_PSEPW
Sequence: MNDSRYIGRFAPTPSGFLHFGSLVAALASWLDARAVNGRWLLRVEDTDPPREMPGARDAILQTLERYGLEWDGEVVFQSQRHPAYAQVVDRMFNMGLAYACTCSRKQLEGYNGIYPGFCRNAGHAREGAAIRLRVPELIYRFTDRVQGTFQQHLGREVGDFVIQRRDGLYAYQLAVVLDDAWQGVTDIVRGADLLDNTPRQLYLQELLGFSQPRYLHIPLIVQPDGHKLGKSYRSPPLEASQATPLLLRALRALGQEADPQLLTATPAEVLAVARQRWQPEAIAQRTTVPEADLY
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: AUSH_ASPCI
Sequence: MPPTREELVSTALNFIAQFAKLDVDSVLSFLSPNCTLRSFPSSLGKPALQTKEESKADFQGLKDFFQNFQLRVKDGSEPVVDEPARRVVLHIEGKGDSLVGRFETEYIYILRMNEEGTMVEDFFQFADSATRDAWGKKIEAHFSARN
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
Austinoid biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the trt14 isomerase family.
Protein: LEUD_MAGSA
Sequence: MEKFTTLTGVAAPLPMINVDTDMIIPKQFLKTIKRTGLGKNLFDEMRYTQDGKEVPDFVLNKPAYRSAKILVAGANFGCGSSREHAPWAIGDFGIRCVIAPSFADIFFNNCFKNGILPIKLPQEQVDKLLDDANRGSNAIVTVDLARQVITGPDGGSISFEVDPFRKHCLLNGLDDIGLTLQREDKIAAFEESRKTSSPWL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: Y1845_CALS4
Sequence: MPRPPKWRWVRSEPNVTYFKPVGIPLSMLEEVILTVEELEAIRLKDLEGLEQEECADMMKVSRPTFFRIITSARQKIADALVNGKAIRVEGGNYKVYGEDMRGHGGMRHRHGWYNEED
What are the official names of this protein?
UPF0251 protein TTE1845.
What is the protein family that this protein belongs to?
Belongs to the UPF0251 family.
Protein: MOAC_BACC3
Sequence: MSSFTHFNDQGRAKMVDISDKKATVRTAIACSSIVVTKEIYDKISHNEIGKGDVLAVAQIAGIMAAKRTSDIIPMCHPLLLKGVDVSFDWKQSDEQYRLLIEVKVKTEGSTGVEMEALTAASATALTVYDMCKAVDKGMIIGETYLLEKTGGKSGDYTRKS
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: RPOA_SINAL
Sequence: MVREKVKVSTRTLQWKCVESRRDSKRLYYGRFILSPLMKGQADTIGIAMARALLGEIEGTCITRAKSENIPHDYSNIVGIQESVHEILMNLNEIVLKSNLYGTRNPFICVQGPGYITARDIILPPSVEIVDNTQHIATLTEPINLCIGLKIERNRGYSLKMSNNFEDRSYPIDAVFMPVQNANHSIHSYGNGNEKQEILFIEIWTNGSLTPKEALYEASRNLINLFIPFLHVEEETFYLENNQHQVTLPVFPFHNKLVNLRQKKKELAFQYIFIDQLELPPRIYNCLKKSNIHTLLDLLNNSQEDLIKMEHFHIEDVKKLLDILEKK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSAL_NEOYE
Sequence: MSEFIKPYNDDPFVGNLSTPVSTSSFSKGTSRNLPAYRRGLSPLLRGLEIGMAHGYFLIGPFDKLGPLRGTDVALLAGFLSSVGLIIILTTCLSMYGNVSFTRADSKDPLQTSEGWGQFTAGFLVGAVGGSGFAYLLLANIPVLQTAGLSLFS
What are the official names of this protein?
Photosystem I reaction center subunit XI, PSI subunit V, PSI-L.
What is the protein family that this protein belongs to?
Belongs to the PsaL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PLSC_MYCGE
Sequence: MDKLFKTSFRFIIRFLQILSLPVVFPYFLLSFLACLITSKNYESLPYNYPPEIRFKKVYRLVSMWLYIKGIKVVTVNDKIIPKKPVLVVANHKSNLDPLVLIKAFGRLKNSPPLTFVAKIELKDTVLFKLMKLIDCVFIDRKNIRQIANALETQQQLIRQGTAIAVFAEGTRILSNDIGEFKPGALKVAYNAFVPILPVSIVGSLGKMESNKRLKEHGVKKSSNYEVKVIFNKLINPISFNQIDSNNLANNIRSIISDAYTSEKPSND
What is the function of this protein?
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
What are the official names of this protein?
Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase, 1-AGP acyltransferase, 1-AGPAT, Lysophosphatidic acid acyltransferase, LPAAT.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Protein: RL29_LISMC
Sequence: MKANDIRDLSTTEIQDQEKALKEELFNLRFQLATGQLENTARIREVRKAIARMKTIVRERELA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: CHED1_DECAR
Sequence: MQHAYDEHLATNRYFDRKFGLEAAKILPGEYYVANQEALLVTVLGSCVAACIRDADSGIGGMNHFMLPDDGGRDKVGMSARYGTYAMEVLINHLLKLGARRNRFEAKVFGGGAVLASLASSNVGARNAEFVLDFLKTEKIPVVAKDLLDSYPRKVYYFPYSGKVLVKKLHRVHNDTLFSRENDYKVRLSGAPMDGDIELFI
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD 1.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: Y5259_BACC1
Sequence: MTENNDIKMVIITGMSGAGKTVALQSFEDLGYFCVDNLPPMLLPKFIELMADSKGKMNKVALGIDLRGREFFEHLWEALDDLSERTWIIPHILFLDAKDSTLVTRYKETRRSHPLAPTGLPLKGIEAERNLLTDMKARANIVLDTSDLKPKELREKIVHLFSTETEQAFRVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIPHMKPLTGLDEEVSSYVLKFNETHKFLEKLTDLITFMLPHYKREGKSQLVIAIGCTGGQHRSVTLTEYLGKHLKPEYSVHVSHRDVEKRKGH
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein BCE_5259.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: DAPF_RICFE
Sequence: MISKINFVKMHGLGNDFVVVNKRDLSSSYDLSQLAKNMADRHTGIGCDQFIIYEEHDDFYEMIIYNIDGSSAKLCGNATRCLAKLIYLDTGKKDITVMVGNKKLLCNVEDENNISVNVGKVSFNEVWMPSRDKIWELAERYMIDLKETICVDIGNPHLVIFSKLEPQDQKIVGEKLQAKELFADGVNVNFAEVKDNKIYLSVWERGAGLTLACGSGACGSFAAGLKLGFIHSPSTVVFKYGSLTMKEENGNIIMQGAATLVARGEYYCEQ
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHBT1_MOUSE
Sequence: MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSAGTSDAACLLDNPLCADVLFVLHDEEHIFAHRIYLATSSSKFYDLFLMECEESPCWGGGAGEEVPCRDFQGRTQSLGSAEEGKEGPQRTPQADPGASSGQDLPESLALQMEASGSEGHALSGWSKGFVSMHREVRVNPISKRVGPVTVVRLDPSMQSGPFRTLLRFLYSGQLDEKEKDLLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFTLDDGAISAHKPLLICSCEWMAAMFGGSFVESANREVHLPNINKMSMQAVLEYLYTKQLSPNLDLDPLELIALANRFCLTHLVALVEQHAVQELTKAAVSGVSIDGEVLSYLELAQFHNANQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALNKHHSRRKWCFWHSSPAVA
What are the official names of this protein?
Rho-related BTB domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
Protein: CBLB_RAT
Sequence: MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFSIPMLDLDDDDDREESLMMNRLASVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPERPPPIPPDSRLSRHFHHGESVPSRDQPMPLEAWCPRDAFGTNQVMGCRILGDGSPKPGVTANSNLNGRHSRMGSDQVLMRKHRRHDLPSEGAKVFSNGHLAPEEYDVPPRLSPPPPVTALLPSIKCTGPIANCLSEKTRDTVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCILNGTHGTPSEMKKSNIPDLGIYLKGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFFDPASGQVPLPPARRAPGDGVKSNRASQDYDQLPSSSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNLEVARSILREFAFPPPVSPRLNL
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.  Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways.  In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production.  Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation.  In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy.  In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation.  Slightly promotes SRC ubiquitination.  May be involved in EGFR ubiquitination and internalization.  May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.  In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase CBL-B, Casitas B-lineage lymphoma proto-oncogene b, RING-type E3 ubiquitin transferase CBL-B, SH3-binding protein CBL-B, Signal transduction protein CBL-B.
Protein: YLOC_BACSU
Sequence: MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLYFEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLSAEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCLMHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDITEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEMKSSIEKIKEQVQNIE
What are the official names of this protein?
UPF0701 protein YloC.
What is the protein family that this protein belongs to?
Belongs to the UPF0701 family.
Protein: TSAD_SHEPW
Sequence: MRVLGIETSCDETGIAVYDDDKGLLSHTLYSQVKLHADYGGVVPELASRDHVRKIVPLIRQALADADMTIEDIDGIAYTKGPGLIGALLVGACVGRALAFSWDKPAIGVHHMEGHLLAPMLEDDVPEFPFLALLVSGGHSMLVGVEGIGRYEVLGESVDDAAGEAFDKTAKLMGLDYPGGPRLSKLAAKGVANSYRFPRPMTDKPGLNFSFSGLKTFAANTIAAEPNDEQTRANIACAFEEAVVDTLAIKCKRALKQTGYQRLVIAGGVSANTRLRAQLAEMMTNLGGKVFYPRGEFCTDNGAMIAYAGLQRLKAGQTDDLGVKGQPRWPLDTLEPVD
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 38K_NPVAC
Sequence: MASSLQSKWICLRLNDAIIKRHVLVLSEYADLKYLGFEKYKFFEYVIFQFCNDPQLCKIIENNYNYCMQIFKAPADDMRDIRHNIKRAFKTPVLGHMCVLSNKPPMYSFLKEWFLLPHYKVVSLKSESLTWGFPHVVVFDLDSTLITEEEQVEIRDPFVYDSLQELHEMGCVLVLWSYGSRDHVAHSMRDVDLEGYFDIIISEGSTVQEERSDLVQNSHNAIVDYNLKKRFIENKFVFDIHNHRSDNNIPKSPKIVIKYLSDKNVNFFKSITLVDDLPTNNYAYDFYVKVKRCPTPVQDWEHYHNEIIQNIMDYEQYFIK
What is the function of this protein?
Plays a role in nucleocapsid assembly and is essential for viral replication.  Distributed over the cylindrical capsid sheath of nucleocapsid.
What are the official names of this protein?
Uncharacterized 38.0 kDa protein in P143-LEF5 intergenic region, ORF2.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host cytoplasm.
Protein: DCRB_SHIFL
Sequence: MRNLVKYVGIGLLVMGLAACDDKDTNATAQGSVAESNATGNPVNLLDGKLSFSLPADMTDQSGKLGTQANNMHVWSDATGQKAVIVIMGDDPKEDLAVLAKRLEDQQRSRDPQLQVVTNKAIELKGHKMQQLDSIISAKGQTAYSSVILGNVGNQLLTMQITLPADDQQKAQTTAENIINTLVIQ
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.  Essential for lipoprotein maturation under conditions where membrane fluidity may be altered.
What are the official names of this protein?
Inner membrane lipoprotein DcrB.
What is the protein family that this protein belongs to?
Belongs to the DcrB family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Periplasmic side.
Protein: YIDC_CERS1
Sequence: MDDQNKNLILATGLSFLVIMVWFFLFPPPEAVTEGETTVATQQTAVAPSATPDAPTTAVPPDAELPETQRVVIDTPRLQGSISMLGGRLDDLSLKSYHETLDPQSQIVRLLSPVGQPNAYYALYGWTPAGALGYEDVPGANTTWTQVGSGALGVDQPVTLQWDNGKGLVFTRTISVDDHYMFSVAQTVENNSGQAVQLAPYGIVARHGKPLNLQNFFVLHEGVVGRADGKLTETKYDKVAELPQVAREGAQAEVIDAQQDGWIGFTDKYWMTTLIPQQGQPFTSVTKYVPGADIYQAETREQLVTVAPGATAEVSSRLFAGAKEWETIRAYQNEGATEPTEGAEPIPGFIDSIDWGWFFFLTKPIFTVLHWLNHMIGNMGLAIIALTFLLKALVLPLAYKSYVSMARMKELQPELEALRERAGDDKMLMQREMMRLYKEKQVNPAAGCLPILIQIPIFFSLYKVIFVTIELRHAPFFGWLKDLSAPDPSSIFNFFGLAPWAAPTPGTTMALIFIGALPILLGVSMWLQQKLNPAPGDKAQAMIFAWMPWVFMFMLGHFASGLVLYWIVNNLITFTQQYVIMRSHGHHPDIFGNIKASFSRKPAAQPAGKAANDGAAPAKKRKP
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.