PharMolix/UniProtQA huggingface dataset:
Protein: LOXL2_XENTR
Sequence: MLVTHIFLLTLSLSVPTLGQYEHWLYYPEYQASQAPEPLPTPARNVPQIHVRLAGEKRKHNEGRVEVYYEGEWGTVCDDDFSMYAAHIVCRELGYQDAVSWSPSSKYGKGEGRIWLDNVNCNGREKSIASCGSNGWGVTDCKHSEDVGVQCSDRRIPGFKVSNELPGQLEGLNIQVEEVRIRAILSAYRKRVPVTEGFVEVKVQGSWRQVCNAEWSSKNSRVVCGMFGFPAEKKFNNKVYKLFSSRRKHTYWQFSANCTGNEAHLSSCKVGGVLTPDPKTNQTCSDGSPAVVSCTPGRAFAPSPGTGFGKAFRQEQPLVRLRGGANTGEGRVEVLKNGEWGTICDDKWNLVTASVVCRELGFGSAKEALAGAQMGQGMGHIHMSEIQCNGFEKSLIDCKFNVHSQGCNHEEDAAVRCNVPAMGFENQVRLSGGRHPTEGRVEVLMERNGTLRWGTVCSDTWGTMEAMIVCRQLGLGFASHAFQETWYWQGDINADDVVMSGVKCSGTEMSLAHCRHDGANINCPRGGGRFAAGVSCVETAPDLVLNAALVEQTTYLEDRPMFMLQCAHEEQCLSSSADRTSPTTGYRRLLRFSSQIHNNGQADFRPKTGRHSWIWHDCHRHYHSMEVFTHYDLLSLNGTKVAEGHKASFCLEDSECETDVQKQYACANFGEQGITVGCWDVYRHDIDCQWVDITDVAPGDYFFQVIINPNQEVAESDYTNNIMKCRCRYDGHRIWMYNCHIGGSYSTETEEKFEHFSGLMNNQLSTR
What is the function of this protein?
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).  Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation.  Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2).  Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription.  LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency.  Involved in epithelial to mesenchymal transition (EMT) and participates in repression of E-cadherin, probably by mediating deamination of histone H3.  When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin.  Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding.  Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
What are the official names of this protein?
Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the lysyl oxidase family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus. Chromosome. Endoplasmic reticulum. Note=Associated with chromatin. It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted. However, a number of reports confirm its intracellular location and its key role in transcription regulation.
Protein: MDH_XYLFT
Sequence: MKALVRVAVTGAAGQIGYSLLFRIAAGEMFGKDRPVILQMLELPDEKAQAALKGVMMELEDCAFPLLAGMVVTDNPDIAFKDADAALLVGSRPRGPGMERKDLLMENAKIFTAQGAALNKVARRDVKVLVVGNPANTNAYIAMKSAPDLNPKHFTAMLRLDHNRALSQLSTKLGKPVANIEKLIVWGNHSPTMYPDYRFATADGTPIIEAINDQAWNANSFIPTVSKRGAAIIEARGLSSAASAANAAIDHMRDWLLGSNGKWITMGVPSDGSYGIPEGMIFGFPVTTTNGEYSIVKDLPIDTFSKTYIDKTLAELEEERASITHLLR
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: SOX6_MOUSE
Sequence: MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHSYNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNNMGLSNCRTEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN
What is the function of this protein?
Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable).  Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis (PubMed:9755172, PubMed:11702786).  Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate (PubMed:11702786, PubMed:15529345, PubMed:26150426).  Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes (PubMed:14993235, PubMed:26150426).  Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts (PubMed:14993235).  Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube (PubMed:26525805).  Binds to the gene promoter of MBP and acts as a transcriptional repressor (PubMed:26525805).
What are the official names of this protein?
Transcription factor SOX-6, SOX-LZ.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: YQJD_ECO57
Sequence: MSKEHTTEHLRAELKSLSDTLEEVLSSSGEKSKEELSKIRSKAEQALKQSRYRLGETGDAIAKQTRVAAARADEYVRENPWTGVGIGAAIGVVLGVLLSRR
What are the official names of this protein?
Uncharacterized protein YqjD.
What is the protein family that this protein belongs to?
Belongs to the ElaB/YgaM/YqjD family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RNFA_HAEI8
Sequence: MTHYILLIIGTALINNFVLVKFLGLCPFMGVSKKIETAVGMGLATMFVLTVASLCAYLVDHYILIPLNATFLRTLVFILVIAVVVQFTEMAINKTSPTLYRLLGIFLPLITTNCAVLGVALLNVNLAHNLTESVVYGFGASLGFSLVLVLFAALRERLVAADIPATFRGSAIALITAGLMSLAFMGFTGLVK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PMTM_ARATH
Sequence: MIKNIFQSRKLSGLCVLSILLVSVTILLLTNDTIDLFPYLSLPYLPRSSLSVIPTSTPISSPTNDSSPPLESPVNQTRVDDHPDDQGLELDWLKDDKQWNVSLKIDWKRCESPDYIPCLDNTKAIKKLKSKRNMEHRERHCPERSPKCLVPLPQHYKVPLPWPQSRDMIWYDNVPHPKLVEYKKDQNWVRKSGPFFVFPGGGTQFKDGVIHYINFIQKTLPILDWGKKVRVVLDVGCGVASFGGTLLDKNVITMSFAPKDEHEAQIQFALERGIPATLAVIGTQKLPFPDNAYDVIHCARCRVHWHGYGGRPLLELNRVLRPGGFFVWSATPVYQHDEGHRNVWKTMESLTTSMCWKVVARTRFTKVGFVIYQKPDSDSCYESRKNKDPPLCIEEETKKNSSWYTPLLTCLPKLPVSPIGKWPSGWPERLTETPVSLFREQRSEESFREDSKLWSGVMSNIYLYSLAINWTRIHNVMDMNAGYGGFAAALINKPLWVMNVIPVEGEDTLSTIFDRGLIGIYHDWCESFNTYPRSYDLLHSSFLFTNLSQRCDLMEVVVEIDRILRPGGYLAVQDTVEMLKKLNPILLSLRWSTNLYRGKFLVGLKSSWRP
What are the official names of this protein?
Probable methyltransferase PMT22.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: HOP_MOUSE
Sequence: MSAQTASGPTEDQVEILEYNFNKVNKHPDPTTLCLIAAEAGLTEEQTQKWFKQRLAEWRRSEGLPSECRSVTD
What is the function of this protein?
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development.  Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development.  Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF.  Overexpression causes cardiac hypertrophy (PubMed:12297045, PubMed:12297046).  Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (By similarity).
What are the official names of this protein?
Homeodomain-only protein, Homeobox-only protein, Odd homeobox protein 1, mOB1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=According to PubMed:14516659 it is cytoplasmic.
Protein: ILVC_METMJ
Sequence: MVQKYYESDADPRTLEDKTIAVIGYGSQGRGQALNLRDSGCRVVIGLRPGGSWQKASEDGFEVYSVAEAVKRADVIQILLPDENQAAVYRAEISPNIRENACLMFSHGFNIHYGQIVPPPTVDVVMVAPKGPGHMVRRTYEEGKGVPALIAVHQDATGQARAIALAYARGIGATRAVVFETTFAEETETDLFGEQAVLCGGITSLIKAGFETLVDAGYAPEMAYLEVLHETKLIVDLIYEGGFTKMRDSISNTAQYGDLTRGPRVIGPETYMAMQEILEEIQNGKFAKEWMLENMVNRPVFNALTRADEEHLIEQVGAEIRGFMPQFRK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: GPMI_PSEMY
Sequence: MSATPKPLVLIILDGFGHSDKPEYNAIHAASTPVYDRLRATYPHGLISGSGMDVGLPDGQMGNSEVGHMNLGAGRVVYQDFTRVTKAIRDGEFFDNAAINQAVDKAVAAGKAVHILGLLSDGGVHSHQDHIVAMAELAARRGAEKIYLHAFLDGRDTPPKSAQPSIELLDAAFARLGKGRIASLTGRYFAMDRDNRWDRVEQAYHLIVDGAGQFNAASAVEGLQAAYERGESDEFVKATTIGAPVQVEDGDAVVFMNFRADRARELTRAFVEPGFQEFERKRAPQVGFVMLTQYAASIPAPAAFAPEALTNVLGEYLAKNGKTQLRIAETEKYAHVTFFFSGGREEPFEGEERILIPSPDVATYDLKPEMSAPEVTDRIVDAIENQRYDVIIVNYANGDMVGHTGVFEAAVKAVETLDTCVGRITEALQKVGGEALITADHGNVEQMEDECTGQAHTAHTCEPVPFIYVGKRPARIREGGVLADVAPTLLTLMGLPQPAEMTGKTIVELE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: PLSX_STRZT
Sequence: MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQYLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGALLAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAKNVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVVADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLNYSDVGGAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: AROQ_BACC1
Sequence: MKKVLLVNGPNLNRLGVREVNVYGKGTLATLEADMKQEAETMGVELECFQSNHEGAIIDRIHEAEDIYEGIILNPGAFTHYSYAIRDAIASISIPVIEVHISNIHQRESFRHESVTAAVCAGQIVGFGFYGYKLALFALMEKLREA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: FLUF_NEUCR
Sequence: MPRQHLTPNACLVCRKKRTKCDGQMPCRRCRSRGEECAYEDKKWRTKDHLRSEIERLRNEQRQGHAVIRALINDEQDWESFLSRIRGDESPEAIADWIRSIRNLFEPLQAASSQSMGGLGAPPTLLSPSQATASESSQLHRAASFAGIGSYNFGQGRVPFDQSTPRSSFSSDLSPTTPFSFREQADFIHAPQPMYPSSRRFSSSSLPSLPLRHSSQPLVPGIFNEPLPHTWTSITSDTQLVQRLLSRFFSAPCSLLCFIPQSSFMKAFREGDSRYCSEALVNAILGKACKSYGTASNIVSRMAFGDAFIGEAKRLLATEPNHTNLPSTQALAVLALAEISEGKDDEAWDLAWASVRAAITREQSFHVDQEFATARAVSYCGGFTLIHMLRLLTGRLDLNTSPFFMRLYQGSEETPEDEPQNRIERGFALHMQFLAELEHCPPLPRFVFEITTAVHTFASYNFSNAATAEELEDAYGKCLDAYKRFEETFCLDMDTTPDLLFAQIWYHYCLLALLRPFVKSTASLRDSAMTTPRLRNDANPSDICQRSSEAIIFLTSTYQTRFSLGNPPELLPHMLFAAVLYQVTLTPDPEHLSTIANDIKPELSESPVMMPSQAAFGAHGNSNLVPPPPMPFNNHGSYFPQPLSPVLKLEVRQAAPRRESSISLSSTFDSCGNRRPSDSFTSSTLTSHDASERESSTSDTQSDFLPFFTSEPADLVTIGSLQLASMQHHGAVEATRLLRSLSTVKDLVGSTLDLETLAEALPFPMGDLNTAVLYTGLGLQRAPVEPMQVTGP
What is the function of this protein?
Required for conidiophore morphogenesis where it has a role in the budding phase.
What are the official names of this protein?
Conidial development protein fluffy.
What are the subcellular locations of this protein?
Nucleus.
Protein: U507_PICGU
Sequence: MAKDGRPSNLPLLYNPLLNCIFNNPNHSRAPYKQIIHELASRHTDFTIIVPPSSLLHNSYDPESLKSSSKIALHDLAYHNEEFIRSHIVKTGSNSHAFLAPVAKVQSAIYNTICGKQILVKNGMIFTGKGFRRSLRAKITDIGYFDSFCDYFPSGSKFMLIYIDNSLYGSSDHPEPALEASPKAQQAKIKRPDQVPTESITFERLLRNFPLLSKSVSDPFYQLFHHNNYQFRVLRTNTHKKLSVIKSEFDNMLEEAYQIISNSVKSDSPDGEQTNNLLHQILRSYPELDLNKLVHEYVEINLYDKLWAQLIFQFSANAGLADPDATKIFTAEKYDELSCLSLNQLDIPVDEPWLLNDLLLRVYNAIIELSKLADATIIESSSKLKIISNTISILTENSNSSLMIDADTLIGLLIMVVVHSKIDFIEAHLYYIKNFMYGTISDDGYLSFIISSFDAVFFHLSHPDEPQYADMKESSQKNFEFWSLIRSHKVDEITALLEETDKLYGDKLPHNHFLKARNINGESALMLAIRSKNYDTFLLLLSRNPNWFSIEDILFDRNTTTSQNLLMVSLMEETKIITKILIEILGSCTLEEQIAYINSTDYSGRSVGHYLFHDYELINEVGHLVNWELKDHNSYTPLFNICRCYDHYAYYDLIKTAFSAVMSPNFNFKKHTDKYGNSILHILLKGIDQSGLLKADKNINVNCTNSKCLTPLTVYVKYGRIENLISLLQDKRLEFMFEDKKNFFNIFDYVAFSSRKQGDNDRGNSEEITSFIYSHYFKHFIPLKCTTVAFNAKFDTTKKDWIVYFHGNQNIILGLDSIKQSHHSFKLKNPHSLIPDVEKVWLNYPANGSVAPIFAKFRMNRLLENLNIFLVCLSMHPNFDTAPHETLGLSSSGNSSSLDQMKEVIGKQESSSKVTPHQLAEIETFLSLSKENLLGTLSTTIKFNKLMTVMNIKMGDLNTIREDSLYSAKMLCDMTPSIKTNYHTPDYGYRTMFQYFIWVELTLIEIIRNVNKVLGRITDWRQCHDRVLSLAGELRKYEDKRHELGTDEHSNSSWFGNIIENKRTRYKKLVLLHSEETKKLGLLSNEIKISHEDIAAEMSHYLMFRSKLIPFAIKQFTRVATTGLNRNGLHVLQ
What are the official names of this protein?
UPF0507 protein PGUG_02975.
What is the protein family that this protein belongs to?
Belongs to the UPF0507 family.
Protein: BCK1_YEAST
Sequence: MPFLRKIAGTAHTHSRSDSNSSVKFGHQPTSSVASTKSSSKSPRATSRKSIYDDIRSQFPNLTPNSTSSQFYESTPVIEQSFNWTTDDHISAGTLENPTSFTNSSYKNDNGPSSLSDSRKSSGGNSVNSLSFDKLILSWDPTDPDEWTMHRVTSWFKFHDFPESWILFFKKHQLFGHRFIKLLAYDNFAVYEKYLPQTKTASYTRFQQLLKKTMTKNVTNSHIRQKSASKLKSSRSSSESIKSKLKNSKSQEDISNSRSTSESALSPTKSGPSKTDEKNFLHSTSTHQKTKSASSLYRRSFISLRGSSSSNASSAKSPSNIKLSIPARPHSIIESNSTLTKSASPPASPSYPSIFRRHHKSSSSESSLLNSLFGSGIGEEAPTKPNPQGHSLSSENLAKGKSKHYETNVSSPLKQSSLPTSDDKGNLWNKFKRKSQIGVPSPNTVAYVTSQETPSLKSNSSTATLTVQTADVNIPSPSSSPPPIPKTANRSLEVISTEDTPKISSTTASFKETYPDCINPDKTVPVPVNNQKYSVKNFLLDQKFYPLKKTGLNDSENKYILVTKDNVSFVPLNLKSVAKLSSFKESALTKLGINHKNVTFHMTDFDCDIGAAIPDDTLEFLKKSLFLNTSGKIYIKDQMKLQQKPKPAPLTSENNVPLKSVKSKSSMRSGTSSLIASTDDVSIVTSSSDITSFDEHASGSGRRYPQTPSYYYDRVSNTNPTEELNYWNIKEVLSHEENAPKMVFKTSPKLELNLPDKGSKLNIPTPITENESKSSFQVLRKDEGTEIDFNHRRESPYTKPELAPKREAPKPPANTSPQRTLSTSKQNKPIRLVRASTKISRSKRSKPLPPQLLSSPIEASSSSPDSLTSSYTPASTHVLIPQPYKGANDVMRRLKTDQDSTSTSPSLKMKQKVNRSNSTVSTSNSIFYSPSPLLKRGNSKRVVSSTSAADIFEENDITFADAPPMFDSDDSDDDSSSSDDIIWSKKKTAPETNNENKKDEKSDNSSTHSDEIFYDSQTQDKMERKMTFRPSPEVVYQNLEKFFPRANLDKPITEGIASPTSPKSLDSLLSPKNVASSRTEPSTPSRPVPPDSSYEFIQDGLNGKNKPLNQAKTPKRTKTIRTIAHEASLARKNSVKLKRQNTKMWGTRMVEVTENHMVSINKAKNSKGEYKEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETFNFKSTRLAKFIKSNDKLNSSKLRITSQENKTE
What is the function of this protein?
Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth.  This pathway seems to start by SMP3; then involve the kinase PKC1 that may act on this kinase.  BCK1 probably phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.
What are the official names of this protein?
Serine/threonine-protein kinase BCK1/SLK1/SSP31.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_BURP0
Sequence: MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGNELRLRTFKLVDQVSGRTLGLRADMTPQVARIDAHLLNRQGVTRLCYAGPVLHTRPRGLHASREQLQIGAEIYGHAGLEADQEIQQLMLDALHLTGLKKIRLDLCHAGVLAALFARDAAAAERGEALYEALAGKDVPRLNELTDDLGADTRAALRALPRLYGDASVLDDARRLLPALPEITRALDDLAHLAAQVKDAEVAIDLADLRGYAYHSGAMFAAYVDGVPNAVAHGGRYDHVGQAYGRARPATGFSLDLREIARISPVEARGAAILAPWKQDDALRAAVGALRDAGEVVIQALPGHDHVLDEFACDRALVERDGAWVIEPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_ERWT9
Sequence: MTRLTLAIDAMGGDFGPCVTVPASLQALESNPHLHLLLVGDPDIITSSLATADSALRARLQIIAAESVIASDARPSQAIRASRGTSMRIALEQVKEGHAQACISAGNTGALMGLAKLLLKPLDGIDRPALMTVLPHQQHGKTVVLDLGANVDSDSAMLVQFAVMGAVVAEEVLAISRPRVALINIGQEDSKGLTSIRDAAAILRAAAEINFIGYLEGNDLLTGKTDVLVCDGFVGNVTLKTMEGVVRMFLSLLKSQGEGKKKAWWLRLLGRILQKRLAKKFGHLNPDQYNGACLLGLRGTVIKSHGAANQRAFTVAIQQAEQAVQRQIPQRIAARLEAVLPKSD
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: PSMD3_BOVIN
Sequence: MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAAAGGGSTGETAGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVHGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASAPLLPEVEAYLQLLMVIFLMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDTDGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 3, 26S proteasome regulatory subunit RPN3.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S3 family.
Protein: URK_LACH4
Sequence: MMGKLEKPVIIGIAGGSGSGKTTIAHEIANNINEHDRIMIMSQDSYYQDNTGVPMEKRMKINYDHPDAFDMPLLEAQLNQLLHRKPIELPTYDFTQHTRSNETIHVEPADIIILEGILVLFNEDIRNLMDIKVYVDTDDDIRFIRRLERDMKERGRSLDSVINQYLGTVKPMYNQFIEPTKRYADIIVPEGGENDVAIDMLTTKLQSVLNQ
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIDH_KLEAE
Sequence: MKHSVSSMNTSLSGKVAAITGAASGIGLECARTLLGAGAKVVLIDREGEKLNKLVAELGENAFALQVDLMQADQVDNLLQGILQLTGRLDIFHANAGAYIGGPVAEGDPDVWDRVLHLNINAAFRCVRSVLPHLIAQKSGDIIFTAVIAGVVPVIWEPVYTASKFAVQAFVHTTRRQVAQYGVRVGAVLPGPVVTALLDDWPKAKMDEALANGSLMQPIEVAESVLFMVTRSKNVTVRDIVILPNSVDL
What are the official names of this protein?
Ribitol 2-dehydrogenase, RDH.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RL32_DROSI
Sequence: MTIRPAYRPKIVKKRTKHFIRHQSDRYAKLSHKWRKPKGIDNRVRRRFKGQYLMPNIGYGSNKRTRHMLPTGFKKFLVHNVRELEVLLMQNRVYCGEIAHGVSSKKRKEIVERAKQLSVRLTNPNGRLRSQENE
What are the official names of this protein?
60S ribosomal protein L32, Ribosomal protein 49.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
Protein: IPK1_ASHGO
Sequence: MVKIIGKGGANYVLAFGNDNDDLYRICVRGRSLRENNRSTVDNYHYALEVVKPQLGEFVCRMELVDLPVCDSLRQVLKSKIEVWDATTVTCLKMPNLVPAGSLSHTVDHFTKIHIGERAIVWEFKPKWLSGNDKYCRNCTLNLLRGQTSISYCHAQLLNPGQAGPILKSLFAGLNVPPAFIEDMEAYIAQPCSVLQRLRVAQEQVDASLGPLDQPDTAASPERCLSMTLKDVSCFVSWHKDASPVAVVVDLDMKPAAKSAHWTALQEQLDRFQPQVRH
What is the function of this protein?
Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
What are the official names of this protein?
Inositol-pentakisphosphate 2-kinase, Inositol-1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase, InsP5 2-kinase.
What is the protein family that this protein belongs to?
Belongs to the IPK1 type 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEUD_AZOSB
Sequence: MKPFTVLDAIVAPLDRANVDTDAIIPKQFLKSIKRSGFGPNLFDEWRYLDVGQPGQDCSNRPKNPDFVLNQARYQGAQVLLARDNFGCGSSREHAPWALEDYGFRVIIAPSFADIFFNNSFKNGLLPIKLDAAELDVLFQQCEATEGYRLKVDLAAQTITRPDGKAIAFDVDPFRKECLLNGWDDIGLTLRHADKIRDFEAKRRAEHPYYFA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: FLIQ_BORBU
Sequence: MTAGHILYLIRISIENIIILSAPMLIIALIVGLLISIFQAITSIQDQTLSFIPKIIVILLVIVIFGPWILNKLMQFTYMIFSQLQNV
What is the function of this protein?
Role in flagellar biosynthesis.
What are the official names of this protein?
Flagellar biosynthetic protein FliQ.
What is the protein family that this protein belongs to?
Belongs to the FliQ/MopD/SpaQ family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.