PharMolix/UniProtQA huggingface dataset:
Protein: ARGI2_RAT
Sequence: MFLRSSVSRLLHGQIPCALTRSVHSVAVVGAPFSRGQKKKGVEYGPAAIREAGLLKRLSMLGCHIKDFGDLSFTNVPKDDPYNNLVVYPRSVGIANQELAEVVSRAVSGGYSCVTLGGDHSLAIGTISGHARHHPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIRELQDKVPQLPGFSWIKPCLSPPNLVYIGLRDVEPAEHFILKSFDIQYFSMRDIDRLGIQKVMEQTFDRLIGKRKRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREGLYITEEIHSTGLLSALDLVEVNPHLATSEEEAKATASLAVDVIASSFGQTREGGHIAYDHLPTPSSPHESEKEECVRI
What is the function of this protein?
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis.  Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS).  Arginine metabolism is a critical regulator of innate and adaptive immune responses.  Seems to be involved in negative regulation of the survival capacity of activated T cells.  May suppress inflammation-related signaling in asthmatic airway epithelium.  May play a role in promoting prenatal immune suppression.  Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction.  Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling.  Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.
What are the official names of this protein?
Arginase-2, mitochondrial, Arginase II, Kidney-type arginase, Non-hepatic arginase, Type II arginase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TOPRS_DROME
Sequence: MAEENPGALAANVPYLGVDELGASVIVEPGLEGSNAGGRTLPAAAIKFADLTESGSESGDNEAEEPVSAGPDNANAIGEPGTSASAAEENGTVERNSPPPNCAICLSRCRRKCFTDSCMHQFCFKCLCEWSKIKPECPLCKQPFRTIIHNVRTLDDYDRYPVQTTSPVPTENPSLRYHIVRRPRYTPLVQNQAVIVNDIEAAIAAGAAGEDVLSAAEVAAGRRSYSRFEPYRSELMNYYQHDQDASTSGSLSQLWRRYVYDRKLYALPVSDSVTGHFREWSARFYRNNPAQIHRLMPWIHRDIMCLLRNAAHSVNTVMTLMSDLLPMTSLLGPTFRRRLSPYLGERTSHFIHELFNFARSPYDINGYDHVVQYSARVAEEVEVDLLDMVETQSSNGDDLNLEVGDSDADAINAGFSPDWSPPRVRPSTSVIVTNPGATHSFSVTMASDGSELPGISIRRTTNVGSQTVAINLSMRRPAAVASEEPEVIEIDDGDAAANAEVAAINDGSNTSRRHAGATLPVTAHIELESSSSSGDEDECVFVLELKPPHMRTPEQVSLDSNSDSDVVFVNEQHEAAPDAIAENRSTQSPLDLASRDQGLFMGPSTSGAAANRGKNWKLVMAQTRRLDQLRTLRSIRSKKSRRSSMPARSDSGSSPSSCSSSSFHFSSSSDEDSSDSSTTNSEPPKKKSRKRVANNKRSKKESIGKRTSRKRKAKDQNMEMLEQQQISQKKPQRQPESSSDSPSSSDDESGGDSSESSGQPNTNNNKSSSDSDDDSAVNMQLSALRATLKAEATLEDRKPVKLELQLPDDDQAGPLHSRMTPSPREDNEPGCSAPKRRRSCSHSNQSSQSASLASSSTATSSSAPLSSFAWGAAGFSGDPLMRGHPAMEEHDIANSLIELSTLTQPVNIGLFNEHYNSAENSMGMLSNTLCDSPQTLAADDANLENYFDTDADPEASRERDAYSLEAAIDVVGESELQIAEDTATATEEQDEEDEEDEDQEEDDQEEEKAAEEEEEEEEDDDDSDNHDENDENQGLLPY
What is the function of this protein?
Functions as a ubiquitin-protein E3 ligase.  Negatively regulates the transcriptional repressor h/hairy by promoting its ubiquitination and subsequent degradation.  Also directs the nuclear organization of the gypsy chromatin insulator.  Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes.  Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effect variegation (PEV).  Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops.  This chromatin looping may require the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery.  Within the gypsy insulator complex, this protein may promote formation of nuclear insulator bodies by recruiting individual insulator complexes to the nuclear lamina.
What are the official names of this protein?
E3 ubiquitin-protein ligase Topors, RING-type E3 ubiquitin transferase Topors, SUMO1-protein E3 ligase Topors, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, dTopors.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with the gypsy chromatin insulator complex on polytene chromosomes and to nuclear insulator bodies. Also localizes to the nuclear lamina.
Protein: MENC_MYCMM
Sequence: MIPGPATLPDLLDRLHVVALPMRVRFRGITTREVALIEGPSGWGEFGAFLEYQPPEAAAWLASAIDAAYGQPPPVRRGRIPINATVPAVPPAQVPELLARFPGARTAKVKVAEPGQTLASDVERVNAVRALVPTVRVDANGGWSVDQAAQAAVALTADGPLEYLEQPCATVGELAELRRRIEVPIAADEAIRKAEDPLAVVRAGAADVAVLKVAPLGGVWALLDIAAQIDIPVVISSALDSAVGIAAGLSAAAALPQLQHACGLGTGGLFVEDVAEPAIPVDGALAPQRVVPDPARLRALGAAPDRRQWWIDRIKACYPLLYRRSGD
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: RODZ_YERPB
Sequence: MNTEASQDQTVTETPGVRLRQARESLGLTQQTVAERLCLKVSTIRDIEEDNAQANLASTFHRGYIRSYAKLVHLPEDELLPILEKQAPVRAAKVAPMQSFSLGKKHKKRDGWLMSFTWLIVLVVLGLTGAWWWQNHQAQQAEIANMVDQSSAQLSQNGGQPVPLTDDNSDAIAPTDAPAPVANGQPVPLTNHSTSAVTNSATTSSATTSSVPTTSSVPKTTLVPKTNSTEPVDTANTNTTMHQEGAASAAVSPSQVPQPGLSTGPSPLPTADAGVSGSTSSVGALVMNFTADCWLQVVDATGKTLFSGIQKGGAVLNLAGKAPYKLTIGAPGALTISYQGNPVDLSKFIKANRVARLTVGVE
What is the function of this protein?
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
What are the official names of this protein?
Cytoskeleton protein RodZ.
What is the protein family that this protein belongs to?
Belongs to the RodZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Forms helical filaments along the long axis of the cell.
Protein: GATA_BACCN
Sequence: MSLFDHSVSELHKKLNNKEISVTDLVEESYKRIADVEDNVKAFLTLNEENARAKAKELDAKIGAEDNGLLFGMPIGVKDNIVTKGLRTTCASKMLANFDPIYDATVVQKLNEADTITIGKLNMDEFAMGSSNENSGFYATKNPWNLEYVPGGSSGGSAAAVAAGEVLFSLGSDTGGSIRQPAAYCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITRTVEDNAYLLQAISGVDRMDATSANIEVGNYLAGLTGDVKGLRIAVPKEYLGEGVGEEARESVLAALKVLEGMGATWEEVSLPHSKYALATYYLISSSEASSNLSRFDGVRYGVRSDNVNNLMDLYKNTRSEGFGDEVKRRIMLGTFALSSGYYDAYYKKAQQVRTLIKNDFENVFANYDVIIGPTTPTPAFKVGEKIDDPMTMYANDILTIPVNLAGVPAISVPCGFGANNMPLGLQIIGKHFDEATIYRVAHAFEQATDYHTKKASL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: BRE2_CAEBR
Sequence: MRQNRRASMIVNRILITLIVLVSLSFLFLRAGPKFSEADRACIQDEWQENKSLNVSSEINNETYQIVFADVQKEFKWIFLPKEISGNPDILMIVSSNRDNFARRNVIRKSWMNSDKNKIVAEKRMKILFLVGVNSENEKENTVVLKEAEVFGDIIVVDLEDNYQNLPYKSLTILLYGQSKTAESVKLIGKIDEDVIFYPDQLTPLINDGTINMSISAIYGEKWNAGVEVSNKDETNKWFIPKYSFKCQLLPSYLSGPFYLTTRKAAERILKSTKHRKFISVEDVFITGLLAGDVGVEKKQLPSMYMYDETTTDTAKAEILAWHNFKNNAEFLESWENLRLSRCKACRKSRNFRGSRSQLDEERNQ
What is the function of this protein?
Transfers N-acetylgalactosamine onto carbohydrate substrates.  Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5.  Involved in resistance to the nematotoxic C. cinerea galectin Cgl2.
What are the official names of this protein?
Beta-1,3-galactosyltransferase bre-2, Bacillus thuringiensis toxin-resistant protein 2, Bt toxin-resistant protein 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: LEC2_CYTSE
Sequence: SNDISFKFDKFDPNGKQLTFQGYASVLDTGVLQLNKVGTGLPKEIGGIARYVAPFQIWSKATGEVASFVTSFQFFLETSPNPANGASDGLTFFLAPPNSPLRRAGGYLGLFETSNKSDSSYQTVAVEFDTVGAPANTWDPGYPHIGVDVNRVTSIKTTKEKWNKRYKREVANVWITYQASSKTLTASLTYPQDQTSDSVSVDFKANLPEWVSVGFTGGTTVGGRETTHEILNWYFSSTLEYQT
What is the function of this protein?
Lactose- or galactose-binding anti-H(O) lectin.
What are the official names of this protein?
Anti-H(O) lectin 2, Anti-H(O) lectin II, CSA-II.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: RIMM_BURVG
Sequence: MSGHDSGNARRGRASFGAFVRKPVERGAAASTGAAAEQGSLEAAQDWPDDAVEVGAVVDAYGLKGWIKVAAHADAGRGGDALLSARRWWLERGAERLSVRILQSKTHGDTVVAQPAGVDDRDAALAMRGFRVFVRREDFPALAADEFYWVDLIGLEVVNEQSVSLGKVSGMIDNGVHSILRVEYPTVGKDGAPATDERLIPFVGVYVKTVDQAARRIVVDWEADY
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G_BPG4
Sequence: MFQKFISKHNAPINSTQLAATKTPAVAAPVLSVPNLSRSTILINATTTAVTTHSGLCHVVRIDETNPTNHHALSIAGSLSNVPADMIAFAIRFEVADGVVPTAVPALYDVYPIETFNNGKAISFKDAVTIDSHPRTVGNDVYAGIMLWSNAWTASTISGVLSVNQVNREATVLQPLK
What is the function of this protein?
Attaches the circulating virion to the bacterial lipopolysaccharides which serve as receptor for the virus.  Determines the phage host-range.  Probably triggers with protein H the injection of the phage DNA into the host cytoplasm upon conformational changes induced by the interaction with host lipopolysaccharides (By similarity).
What are the official names of this protein?
Major spike protein G, G protein, GPG.
What is the protein family that this protein belongs to?
Belongs to the microvirus G protein family.
What are the subcellular locations of this protein?
Virion.
Protein: BPT_ACIB5
Sequence: MKSYHPKSLLNDLQYYITPPHDCSYLENKSARMVFLDPIHRIDVVTLSELSRLGFRRSGDFVYRPECHLCRQCLSCRVPVADFQMNSMQKKAWKRNQDLTMTVLPTRQASQIHYDLYERYINERHADGDMFPPSLDQFEKFLVHSCTDSFFLELWKDNRLISVSTCDLMDDGLSAVYTFFDPDEHRRSLGVYSILNQIEYVKTLGLEYVYLGYWVPHSAKMNYKSQYTPLELLLDGQWRRLNRSLSPEEINQLGNSLMTTLPSEWNNLIIK
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM11D_RAT
Sequence: MYRPRSMVSPSRFFNPFMVALIVIITVGLLAMTAGLLIHFLAFDKRAYFYHSNFHILNVDYTEALNSPATHEYRTLSERIESMITDAFRESNLRSEFIRTHVVKLRKEGSGVVADVVMKFRSSKRNNKKAIKTRIQSVLQRLSSSGNLEIAPSNGITSLTDQDTENVLTQECGARPDLITLSEERIIGGTQAETGDWPWQVSLQLNNVHHCGGTLISNLWVLTAAHCFRSYSNPQQWTATFGVSTISPRLRVRVRAILAHAEYNSITRDNDIAVVQLDRPVTFTRNIHRVCLPAATQNIMPDSVAYVTGWGSLTYGGNTVTNLQQGEVRIVSSEVCNEPAGYGGSVLPGMLCAGVRSGAVDACQGDSGGPLVQEDTRRLWFVVGIVSWGYQCGLPNKPGVYTRVTAYRNWIRQQTGI
What is the function of this protein?
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.  Plays a role in the proteolytic processing of ACE2.  Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides (By similarity).  Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC.
What are the official names of this protein?
Transmembrane protease serine 11D, Adrenal secretory serine protease, AsP, Airway trypsin-like protease, AT.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Transmembrane protease serine 11D catalytic chain]: Secreted. Note=Activated by cleavage and secreted.
Protein: VIT2_CHICK
Sequence: MRGIILALVLTLVGSQKFDIDPGFNSRRSYLYNYEGSMLNGLQDRSLGKAGVRLSSKLEISGLPENAYLLKVRSPQVEEYNGVWPRDPFTRSSKITQVISSCFTRLFKFEYSSGRIGNIYAPEDCPDLCVNIVRGILNMFQMTIKKSQNVYELQEAGIGGICHARYVIQEDRKNSRIYVTRTVDLNNCQEKVQKSIGMAYIYPCPVDVMKERLTKGTTAFSYKLKQSDSGTLITDVSSRQVYQISPFNEPTGVAVMEARQQLTLVEVRSERGSAPDVPMQNYGSLRYRFPAVLPQMPLQLIKTKNPEQRIVETLQHIVLNNQQDFHDDVSYRFLEVVQLCRIANADNLESIWRQVSDKPRYRRWLLSAVSASGTTETLKFLKNRIRNDDLNYIQTLLTVSLTLHLLQADEHTLPIAADLMTSSRIQKNPVLQQVACLGYSSVVNRYCSQTSACPKEALQPIHDLADEAISRGREDKMKLALKCIGNMGEPASLKRILKFLPISSSSAADIPVHIQIDAITALKKIAWKDPKTVQGYLIQILADQSLPPEVRMMACAVIFETRPALALITTIANVAMKESNMQVASFVYSHMKSLSKSRLPFMYNISSACNIALKLLSPKLDSMSYRYSKVIRADTYFDNYRVGATGEIFVVNSPRTMFPSAIISKLMANSAGSVADLVEVGIRVEGLADVIMKRNIPFAEYPTYKQIKELGKALQGWKELPTETPLVSAYLKILGQEVAFININKELLQQVMKTVVEPADRNAAIKRIANQIRNSIAGQWTQPVWMGELRYVVPSCLGLPLEYGSYTTALARAAVSVEGKMTPPLTGDFRLSQLLESTMQIRSDLKPSLYVHTVATMGVNTEYFQHAVEIQGEVQTRMPMKFDAKIDVKLKNLKIETNPCREETEIVVGRHKAFAVSRNIGELGVEKRTSILPEDAPLDVTEEPFQTSERASREHFAMQGPDSMPRKQSHSSREDLRRSTGKRAHKRDICLKMHHIGCQLCFSRRSRDASFIQNTYLHKLIGEHEAKIVLMPVHTDADIDKIQLEIQAGSRAAARIITEVNPESEEEDESSPYEDIQAKLKRILGIDSMFKVANKTRHPKNRPSKKGNTVLAEFGTEPDAKTSSSSSSASSTATSSSSSSASSPNRKKPMDEEENDQVKQARNKDASSSSRSSKSSNSSKRSSSKSSNSSKRSSSSSSSSSSSSRSSSSSSSSSSNSKSSSSSSKSSSSSSRSRSSSKSSSSSSSSSSSSSSKSSSSRSSSSSSKSSSHHSHSHHSGHLNGSSSSSSSSRSVSHHSHEHHSGHLEDDSSSSSSSSVLSKIWGRHEIYQYRFRSAHRQEFPKRKLPGDRATSRYSSTRSSHDTSRAASWPKFLGDIKTPVLAAFLHGISNNKKTGGLQLVVYADTDSVRPRVQVFVTNLTDSSKWKLCADASVRNAHKAVAYVKWGWDCRDYKVSTELVTGRFAGHPAAQVKLEWPKVPSNVRSVVEWFYEFVPGAAFMLGFSERMDKNPSRQARMVVALTSPRTCDVVVKLPDIILYQKAVRLPLSLPVGPRIPASELQPPIWNVFAEAPSAVLENLKARCSVSYNKIKTFNEVKFNYSMPANCYHILVQDCSSELKFLVMMKSAGEATNLKAINIKIGSHEIDMHPVNGQVKLLVDGAESPTANISLISAGASLWIHNENQGFALAAPGHGIDKLYFDGKTITIQVPLWMAGKTCGICGKYDAECEQEYRMPNGYLAKNAVSFGHSWILEEAPCRGACKLHRSFVKLEKTVQLAGVDSKCYSTEPVLRCAKGCSATKTTPVTVGFHCLPADSANSLTDKQMKYDQKSEDMQDTVDAHTTCSCENEECST
What is the function of this protein?
Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo.
What are the official names of this protein?
Vitellogenin-2, Major vitellogenin, Vitellogenin II.
Protein: LEU1_VIBVU
Sequence: MNDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSPGDFESVQTIARNIKNSRVCALSRAVEKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYDDVVEMGVRAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMIIKTRQELLGVRTGINHEEIHRTSKLVSQLCNMPIQANKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDAMGYKEDEYNLDALYQDFLKLADRKGQVFDYDLEALMHFSNLREEDDYYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYRLTGYDIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGISTDIVEASGQALLHVINSIHRADEIAEMKQKKIATV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: HXA4_HETFR
Sequence: MTMSSFLINSNYVEPKFPPCEEYSQNNYIPSQSPEYYERPRDPGFHHEALYPQSNYPEPTYSFNNVQGTGNQDMSQRGHVQSQASLQNHIPRQNQLCEVVPVATPALCSQNAKNPTAQKGTLSKEPIVYPWMKKIHVTTVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSASSSSSTSQQTQVSSQGPQPDGSAPNSSSL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A4.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL16_FUSNN
Sequence: MLMPKRTKHRKMFRGRMKGAAHKGNFVAFGDYGLQALEPSWITNRQIESCRVAINRTFKREGKTYIRIFPDKPITARPAGVRMGKGKGNVEGWVSVVRPGRILFEVSGVTEEKAAAALRKAAMKLPIRCKVVKREEKENGGEN
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: NADK_LEUMM
Sequence: MKIAIFNNHAEHSVIIAKKLILAMKKNNVDIDDRNPDIVVSVGGDGTLLGAFQKYVDQTESVRFVGLHTGHLGFYTDWLSTELDQFVDSLIHDNGQKVSYPLLELTVVRTSGESYKFLALNEAVIKQPIGTLVADIYLGGQAFERFRGDGIAVATPTGSTAYNKANGGAVLHPSLPAIQMSEIASINNRVFRTLGSPLIVPQDQEIVMKPKSNHFLVMYDQEEIKGHNITELRFKVSEKRVHFAQYRHVDFWRRVQNAFISEIE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: US9_EHV1B
Sequence: MEKAEAAAVVIPLSVSNPSYRGSGMSDQEVSEEQSAGDAWVSAAMAAAEAVAAAATSTGIDNTNDYTYTAASENGDPGFTLGDNTYGPNGAASGCPSPPSPEVVGLEMVVVSSLAPEIAAAVPADTIFASAAAPATRVDDGNAPLLGPGQAQDYDSESGCYYSESDNETASMFIRRVGRRQARRHRRRRVALTVAGVILVVVLCAISGIVGAFLARVFP
What is the function of this protein?
Essential for the anterograde spread of the infection throughout the host nervous system.  Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips (By similarity).
What are the official names of this protein?
Envelope protein US9 homolog, Envelope protein 76, ORF76 protein.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae envelope protein US9 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host Golgi apparatus membrane; Single-pass type II membrane protein. Host smooth endoplasmic reticulum membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein.
Protein: EST4A_MOUSE
Sequence: MAEAGWNMKWILGLSLTLCLVVQTALGALHTKEPLLITKHGILQGKQVHVGDTPIQVFLGIPFSKPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQILSMYLNTRKQYKWLHFSEDCLYLNVYAPVLAPGAPLLPVMVWFPGGAFLAGSASTYEGSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSPLAQGLFHQAISQSGTAVLKAFITPDPLTSAKKIAHLAGCDHNSTKVMVECLRSLSAEEVTLVSKRMSFFQANSHKDPKEIVWFLSPVVDGVVFPEDPVVLLTRGQVKPVPYLLGVNNAEFEWNLPFLMKIQLNQRMMNQTNINKILWSFNVLLNITKEQVPVVAREYLNDAISNHDWKMFRNRLIDLIGDATFVYATLQAARYHRDAGSPVYLYEFKHHASSGIIIKPYNGADHGDELSYLFGSPFSKGSSAGEEKEFSLQMMKYWANFAHTGNPNGEKLPYWPRFDKDEKYLQLDFDTRVGVKLKEKKMAFWSQLRQSQKP
What is the function of this protein?
Probable carboxylesterase.
What are the official names of this protein?
Carboxylesterase 4A.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: PECA1_RAT
Sequence: MLLALLLTMLLYASLQAQENSFTINSIHMESRPSWEVSNGQKLTLQCLVDISTTSKSRPQHQVLFYKDDALVYNVSSSEHTESFVIPQSRVFHAGKYKCTVILNSKEKTTIEYQLTVNGVPMPEVTVDKKEVTEGGIVTVNCSMQEEKPPIYFKIEKVELGTKNVKLSREKTSNMNFVLIEFPIEEQDHLLVFRCQAGVLSGIKMQTSEFIRSEYVTVQEFFSTPKFQIQPPEMIIEGNQLHIKCSVQVAHLAQEFPEIIIQKDKAIVATSKQSKEAVYSVMALVEHSGHYTCKVESNRISKASSILVNITELFPRPKLELSSSRLDQGEMLDLSCSVSGAPVANFTIQKEETVLSQYQNFSKIAEERDSGLYSCTAGIGKVVKRSNLVPVQVCEMLSKPRIFHDAKFEIIKGQIIGISCQSVNGTAPITYRLLRAKSNFQTVQKNSNDPVTFTDKPTRDMEYQCIVDNCHSHPEVRSEILRVKVIAPVDEVTISILSGNDVQSGDEMVLRCSVKEGTGPVTFQFYKEKEGRPFHEETVNDTQVFWHHEQTSKEQEGQYYCTAFNRASIVTSLRSGPLTVRVFLAPWKKGLIAVVVIGVVIAALIVAAKYYFLRKAKAKQKPVEMSRPAVPLLNSNSEKVSEPSVETNSHYDSQNMDVEYTEVEVSSLEPHQENGRLP
What is the function of this protein?
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions.  Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes.  Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions.  Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils.  Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal.  Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes.  Modulates bradykinin receptor BDKRB2 activation.  Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells.  Induces susceptibility to atherosclerosis.
What are the official names of this protein?
Platelet endothelial cell adhesion molecule, PECAM-1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.
Protein: DBP10_LODEL
Sequence: MTMSDIEDSDVENYDIAGKLALRSDDELGSDDEQNTSGEEGEEVELQDEIVSSDDDDDDGDKGKDTGKMPPTKKAKLDRKPGSDFDFASLDFEAEDNEEEDKTLSSILALSNPTAKKAKAGSFASFGFSKFLLANIAKKGYKQPTPIQRRSIPLIIDNRDVVGMARTGSGKTAAFVLPLIEKLKLRSPSGVRAVILSPSRELALQTYKQVKEFSHGTNLQSIVLIGGDSLEEDFGKMMTKPDIIVCTPGRFLHLKVEMQYDLMSVQYIVFDEADRLFEMGFAEQLNELLLALPSNRQSLLFSATLPRSLVEFAKAGLTNPVLVRLDADSKLSENLQMAYFTTKRNEREANLLYILQEVIKMPLGTPEEVKKLAAMDKRSIESDEENEEAKEQNNGKKRKYKFKKERMPSAKELPSEKSTIIFVPTKHHVEYVTSLLKDAGYLVSYIYGTLDQHARKNQLYLFRIGLTKILVVTDVAARGIDIPVLANVINFTLPGSSKIFIHRVGRTARAGNKGWAYSIVNSSELPYLLDLEIFLGKKLLLTSMHEAKCELLKKKQGGSFIPPRINYTERLVVGAIPRLDLETFQELYENLLRNNYEIKVLKDVAAKGEKLYHRTRQPASQESLKRSKEILETNSWDDQHLLFGENLEKMKDDFLAKLQNRNVKETVFELKKKGVKENDSLAEFMHRRRRQLAPIQRKAQERKELLQKERLAGLSHGIEEEVLKIDGEASGYNQNVDEAELQETFELGDEAHNKKKTFKDPQFFMSHYAPASVIQDQQLSIASSFANDAQAATFDLDNDDKLQKNKQQVMKWDKKKGKYINSMSTDKKYIISENGTKIPATFRSGKFDEWRKQRNLKPTSSLTNNETPENNKRFKHKKQSVPKLPDKYRDDYHKQKQKVEKALDSGMRVKGYNKPGMQQELKSTEQIRKARAIKEQRRAKNARPSRRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP10.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GLPE_YERPE
Sequence: MEQFEATSVEQAYLRWKEGKTALVDIRDPQSYEAGHAPGAFHLTNSSLHTFMQQTDFDQPVMVMCYHGNSSKGAAQYLLQQGFDVVYSIDGGFEAWARSYPQDITSESR
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.