PharMolix/UniProtQA huggingface dataset:
Protein: CNO11_HUMAN
Sequence: MPGGGASAASGRLLTAAEQRGSREAAGSASRSGFGGSGGGRGGASGPGSGSGGPGGPAGRMSLTPKELSSLLSIISEEAGGGSTFEGLSTAFHHYFSKADHFRLGSVLVMLLQQPDLLPSAAQRLTALYLLWEMYRTEPLAANPFAASFAHLLNPAPPARGGQEPDRPPLSGFLPPITPPEKFFLSQLMLAPPRELFKKTPRQIALMDVGNMGQSVDISGLQLALAERQSELPTQSKASFPSILSDPDPDSSNSGFDSSVASQITEALVSGPKPPIESHFRPEFIRPPPPLHICEDELAWLNPTEPDHAIQWDKSMCVKNSTGVEIKRIMAKAFKSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQSSQITEYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGETPSETKMSK
What is the function of this protein?
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.  Additional complex functions may be a consequence of its influence on mRNA expression.  Is required for the association of CNOT10 with the CCR4-NOT complex.  Seems not to be required for complex deadenylase function.
What are the official names of this protein?
CCR4-NOT transcription complex subunit 11.
What is the protein family that this protein belongs to?
Belongs to the CNOT11 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LIS1_FUSV7
Sequence: MSRTLTSRQAEELHKSIIAYLAANNFQDSVTAMRTELNLGEEIFDPATAKKYETLLEKKWTSVVRLQKKTELDSATPTSLSNRKQDPASWLPAGPPRHVLQSHRTPINCVAFHPIYSSIASGDEDAIIKIWDWEFGELERTVKGHTKAVLDLDYGGPKGHTLLASCSSDLTIKLWDPSDEYKNIRTLPGHDHSVSAVRFIPSGAPGAPLSGNLLASASRDVTVRIWDVTTGYCLKTIRGHSDWIRDVSPSLDGKYLLSTGNDRTLRLWDISMNTPETKMVMIGHEHCVECCAFAPPTSYQHLATMAGLKKAPPASSTAEFMATGSRDKTIRLWDSRGTCIKTLIGHDNWVRSLVFHPSGKFLLSVSDDKTIRCWDLSQEGKCVKTLEGMHEHFITSLRWAPPITKGPADEANGEIGTPKKAAAAPLDVQIRCVIATGSVDTSLRIFSR
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein PAC1, Lissencephaly-1 homolog, LIS-1, nudF homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Protein: LEU3_MYCTU
Sequence: MKLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATRGSERLATSDVGERIAAAL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAPR_BACC7
Sequence: MKKRRSKKERQELLQQTIETNPFITDEDLAEKFQVSIQTVRLDRMELSIPELRERIKHVATKQHEEDVKSLPLEEVVGEIIDIELDRHAISIFEVKVEHVFKRNQIARGHHLFAQANSLAVAVIDEELALTAKSTIRYIRPVKLGERVVAKARVEDVENDKGRTVVKVRSFVGEELVFTGTFEMYRSSNYSEEGNNL
What is the function of this protein?
Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.
What are the official names of this protein?
Transcription factor FapR, Fatty acid and phospholipid biosynthesis regulator.
What is the protein family that this protein belongs to?
Belongs to the FapR family.
Protein: ECFA2_LISW6
Sequence: MEIKLEQLGYCYQKNSPFEKRALLDVNVSFDSGSYSAIIGHTGSGKSTLLQHLNALLMPTEGKITVGEREIVAGVKQKKLRDLRKKVGIVFQFPEAQLFEETVEKDICFGPMNFGVSEEDAKLRAKKVIYEVGLTEEILSRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPTAGLDPHGREEIMEMFYNLHKEKGLTTVLVTHSMEDAARYAEKIVLMKAGTVLQIGSPREIFAKPDALVDLGLSVPDVVRFQGLFERKFNVKLTKTCLTIAELITEMAPYLAKGGA
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CAZA2_RABIT
Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAIESWRSSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTVTPSITQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEAQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-2, CapZ alpha-2.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: CA4B_CONER
Sequence: GCCGKYPNAACHPCGCTVGRPPYCDRPSGG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  This toxin binds with high affinity to both fetal (alpha-1/beta-1/epsilon/delta subunits) and adult (alpha-1/beta-1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR).
What are the official names of this protein?
Alpha-conotoxin EIVB.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RAB8B_MOUSE
Sequence: MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSTNVEEAFFTLARDIMTKLNRKMNDSNSSGAGGPVKITESRSKKTSFFRCSLL
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  That Rab may be involved in polarized vesicular trafficking and neurotransmitter release.  May participate in cell junction dynamics in Sertoli cells (By similarity).
What are the official names of this protein?
Ras-related protein Rab-8B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or Mycobacterium.
Protein: SAHH_BORPE
Sequence: MNAVTDKSVADYIVADMALAGWGRRELAIAETEMPGLMAIRDEYAASQPLKGARIAGSLHMTIQTGVLIETLVALGAEVRWASCNIFSTQDHAAAAIAATGTPVFAIKGETLEEYWQYTHKIFEWPEGRHANMILDDGGDATLLLHLGARAEQDISVLAKPGSEEERVLFAAIKETLGRDPKWYSTRLAQIKGVTEETTTGVHRLYQMSQKGELAFAAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMVAGKIAVVAGYGDVGKGCAQALVALRAQVWVTEIDPICALQAAMEGFKVVTMEEAAAHADIFVTATGNYHVITRQHMEAMKDQAIVCNIGHFDNEIDVAGLENCQWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCATGHPSFVMSSSFANQTIAQIELFTRNEAYTTGQVYVLPKHLDEKVARLHLKKLGVKLSTLSKQQADYIGVPVEGPFKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDCI_SALTY
Sequence: MNVIAIMNHMGVYFKEEPIRELHRALEGLNFRIVYPNDREDLLKLIENNSRLCGVIFDWDKYNLELCEEISKLNEYMPLYAFANSYSTLDVSLNDLRMQVRFFEYALGAAADIAAKIRQNTDEYIDNILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSIFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLIDRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDYIKKTLDVKSIHFDSAWVPYTNFSPIYQGKCGMSGDRVEGKIIYETQSTHKLLAAFSQASMIHVKGDINEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLKSESDGWFFDVWQPEHIDGAECWPLRSDSAWHGFKNIDNEHMYLDPIKVTILTPGMKKDGTMDEFGIPASLVAKYLDERGIIVEKTGPYNLLFLFSIGIDKTKALSLLRALTEFKRAFDLNLRVKNILPALYREAPEFYENMRIQELAQNIHKLVEHHNLPDLMYRAFEVLPKMVMTPYTAFQKELHGETEEVYLEEMVGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKENTK
What are the official names of this protein?
Inducible lysine decarboxylase, LDC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-I family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2EB_SCHPO
Sequence: MSSLSDQLSSFKKKVANQPIYAKPQPRQPASPTPTAYLNSNDGHSSAASSPGSYSLKKKRSKTSLVYSQPADSGVGTHYLSQLHYAVEYLKERNEPKTAEEIASYLSTPLTPMLLNLLKKNNRIYYDERNETFTFKPLHNIRSGAGLLAYLDSQKTHVGMSIKELRDGWPNVTVELEELEKQGEVLLLRTRKDGVPKMVWRNDKSCDCHVDKEFQQVWHEIPIPPTLDLASELGKYGLKPTSVDPSTVKRAGHNQTPKQKKPKTRRGKITNTHLNILRDYSSMKP
What is the function of this protein?
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH.  Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
What are the official names of this protein?
Transcription initiation factor IIE subunit beta, TFIIE-beta.
What is the protein family that this protein belongs to?
Belongs to the TFIIE beta subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MMP20_MOUSE
Sequence: MKVLPASGLAVLVTALKFATADPNLLAATPRTFRSNYHLAQAYLDKYYTKKGGPQAGEMVARESNPMIRRIKELQIFFGLKVTGKLDQNTMNVIKKPRCGVPDVANYRLFPGEPKWKKNILTYRISKYTPSMSPTEVDKAIQMALHAWSTAVPLNFVRINSGEADIMISFETGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLGHSTDPSALMYPTYKYQNPYRFHLPKDDVKGIQALYGPRKIFPGKPTMPHIPPHKPSIPDLCDSSSSFDAVTMLGKELLFFKDRIFWRRQVHLPTGIRPSTITSSFPQLMSNVDAAYEVAERGIAFFFKGPHYWVTRGFHMQGPPRTIYDFGFPRHVQRIDAAVYLKEPQKTLFFVGEEYYSYDERKKKMEKDYPKNTEEEFSGVSGHIDAAVELNGYIYFFSGRKTFKYDTEKEDVVSVVKSSSWIGC
What is the function of this protein?
Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP).  May play a central role in tooth enamel formation.  Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
What are the official names of this protein?
Matrix metalloproteinase-20, MMP-20, Enamel metalloproteinase, Enamelysin.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: MURC_FLAJ1
Sequence: MNLNQIENVYFIGIGGIGMSALARYFKYIGKKVSGYDKTPSMLTSELIESGIDIHFEDNINLIPSNYYVENTLVIFTPAVPASHSEWHYFIERNYQIKKRAEVLGIITKDTFSFAVAGTHGKTTTSSILGHILHQSGADVTAFVGGIVENYNSNLIGTGKTVTVVEADEFDRSFLHLHPDIACVTSMDADHLDIYGTSDAIQASFIEFASKVEDKSKLFITKELPLEGVQCAINEDAVYKAYNVRIEDGNYVFDVQTPSEIMKDLRFGLPGKHNLMNGLMAIAMAKTYGTPTDAIAKAIASFNGIRRRFSYQIKSDKLVYIDDYAHHPTEINAVHQAVRELYPGRKVLAVFQPHLFSRTRDFADGFAESLSQFDEVFLMDIYPARELPMEGITSQWLLDKMTNPNRKIVAKEDLLAEIKASDAPIIVTIGAGDIGEMVPSIKKMLNENI
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAI_AMBTC
Sequence: MTDFNLPSIFVPLIGLFFPAIAMASLFLHVQKNKIV
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII, PSI-I.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HLY1_VIBPA
Sequence: MKHQYFAKKSFLFISMLAAFKTSAFELPSVPFPAPGSDEILFVVRDTTFNTQAPVNVKVSDFWTNRNVKRKPYEDVYGQSVFTTSGTKWLTSYMTVNINDKDYTMAAVSGYKSGHSAVFVKSGQVQLQHSYNSVANFVGEDEGSIPSKMYLDETPEYFVNVEAYESGSGNILVMCISNKESFFECKHQQ
What is the function of this protein?
Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.
What are the official names of this protein?
Thermostable direct hemolysin 1, Kanagawa phenomenon-associated hemolysin.
What is the protein family that this protein belongs to?
Belongs to the TDH hemolysin family.
Protein: AT2A2_CANLF
Sequence: MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDSCSLNEFTITGSTYAPIGEVHKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKVMSVIREWGSGSDTLRCLALATHDNPLRREEMNLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKDDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEPAILE
What is the function of this protein?
Involved in the regulation of the contraction/relaxation cycle.  Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation.  Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation.
What are the official names of this protein?
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA2, SR Ca(2+)-ATPase 2, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRI44_PONAB
Sequence: MASGVGAAFEELPHDGTCDECEPDEAPGAEEVCRECGFCYCRRHAEAHRQKFLSHHLAEYVHGAQAWTPPADGEGAGKEEAEVKVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPEIEMEAERVAKRKCPDHGLDLSTYCQEDRQLICVLCPVIGAHQGHQLSTLDEAFEELRSKDSGGLKAAMIELVERLKFKSSDPKVTRDQMKMFIQQEFKKVQKVIADEEQKALHLVDIQEAMATAHVTEILADIQSHMDRLMTQMAQAKEQLDTSNESAEPKAEGDEEGPSGASEEEDT
What is the function of this protein?
May play a role in the process of differentiation and maturation of neuronal cells (By similarity).  May regulate the activity of TRIM17 (By similarity).  Is a negative regulator of PAX6 expression (By similarity).
What are the official names of this protein?
Tripartite motif-containing protein 44.
Protein: LRC59_MOUSE
Sequence: MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATVLDLSCNKLSTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNRLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQQAKEAKERELRKREKAEEKERRRKEYDAQKASKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKVLLLLLLLCVAGGLVVCRVTGLHQQPLCTSVNTIYDNAVQGLRHHEILQWVLQTDSQQ
What is the function of this protein?
Required for nuclear import of FGF1, but not that of FGF2.  Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity).
What are the official names of this protein?
Leucine-rich repeat-containing protein 59.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.
Protein: GATA_LACLS
Sequence: MSYNNKSIKELHELLVNKEISALELTKATLSDIQAREPQIDAFLKVTEEKALKEAAAIDARGINPDVVTDGISIGVKDNIVTEGIETTAASKILGGWIPPYNATVANKLSQSGLITIGKLNMDEFAMGGSGENSSIKPTKNVWDQTKVPGGSSSGSAASVASGEVRLSLGSDTGGSIRQPAAFNGIVGLKPTYGRVSRFGLIAFASSLDQIGPLTPTVEENAQLLNVISGFDKNDSTSSNVSVPDFTSKIGQDIKGMKIALPKEYFGEGIDEKVKEQILAAAKHLEKLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRAQDIKNLEDLYVKSRSEGFGPEVQRRIMLGTFSLSAGSYDKHFKKAGQVRTLIINDFAKVFEKYDLILGPTTPTAAWDLGARVDDPISMYLADLLTIPVNLAGLPGISIPAGFADGLPVGMQLIGKRYDEETIYQVAAAFEATTDFHKKQPIIFGK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: DNAA1_CHLCV
Sequence: MLTCSDCSTWEQFVNYVKTRCSKTAFENWISPIQIIEETQEKIRLEVPNIFVQNYLLDNYKQDLCSFVPLDAQGEPALEFVVAEIKKAPAQPIAPREPQESPAETFEESKDFELKLNAAYRFDNFIEGPSNQFVKSAAVGIAGRPGRSYNPLFIHGGVGLGKTHLLHAVGHYVREHHKNLRVHCITTEAFINDLVQHLRLKSIDKMKNFYRSLDLLLVDDIQFLQNRQNFEEEFCNTFETLINLNKQIVITSDKPPGQLKLSERIIARMEWGLVAHVGIPDLETRVAILQHKAEQKGLHIPNEIAFYIADHIYGNVRQLEGAINKLTAYCRLFGKTLTESIVRDTLRELFRSPSKQKVSVESILKSVATVFQVKLQDLKGTSRSKELVLARQVAMYLAKTLITDSLVAIGSAFGKTHSTVLYACKTIEQKIEKDETLTRQISLCKNHIVG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA 1.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_STRPM
Sequence: MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLLKVDKHIATIYLDQMKELFWEKNLKDVILTAGFEVYNAQISVDYVFEEDLMIEQNQTKINQKPKQQALNSLPTVTSDLNSKYSFENFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHLLNAIGNSVLLENPNARIKYITAENFINEFVIHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALHNNNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEGALKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPIEEIQAQVGKFYGVTVKEIKATKRTQNIVLARQVAMFLAREMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMISQDESLRIEIETIKNKIK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COHE_ECOLI
Sequence: MKTIHDIRRSNARKLRDGVGGNSSFATMIDREPTQTSRFMGDGATKNIGDSMARHIEKCFDLPVGWLDQEHQTTNITKKPDVSITNKQITLVPVISWVQAGAWKEVGYSEVDLSTAETYPCPVPCGEMTYILRVIGDSMIDEYRPGDMIFVDPEVPACHGDDVIALMHDTGETTFKRLIEDGTQRYLKALNPNWPEPYIKINGNCSIIGTVIFSGKPRRYKIKA
What are the official names of this protein?
Prophage repressor CohE, Putative lambdoid prophage e14 repressor protein C2.
Protein: SNO4_YEAST
Sequence: MTPKRALISLTSYHGPFYKDGAKTGVFVVEILRSFDTFEKHGFEVDFVSETGGFGWDEHYLPKSFIGGEDKMNFETKNSAFNKALARIKTANEVNASDYKIFFASAGHGALFDYPKAKNLQDIASKIYANGGVIAAICHGPLLFDGLIDIKTTRPLIEGKAITGFPLEGEIALGVDDILRSRKLTTVERVANKNRAKYLAPIHPWDDYSITDGKLVTGVNANSSYSTTIRAINALYS
What is the function of this protein?
Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step.  May play a role in detoxifying endogenously produced glyoxals.  Involved in protection against reactive oxygen species (ROS) (By similarity).  Important for viability in stationary phase.  May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893).
What are the official names of this protein?
Probable glutathione-independent glyoxalase SNO4, Glyoxalase 3 homolog 4, Heat shock protein 34, SNZ proximal open reading frame 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family. HSP31-like subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Present in processing bodies (P-bodies) and stress granule (SG) foci upon glucose starvation and heat shock.
Protein: PUR5_SINMW
Sequence: MSQSGKNGLTYSDAGVDIDAGNLMVEKIKPHVRSTRRPGADGEIGGFGGLFDLKAAGFSDPVLVAANDGVGTKLKIAIDAGKHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVAGIAAGCREAGCALIGGETAEMPGMYSGGDYDLAGFAVGAAERGQLLPAGNIAEGDVILGLSSSGVHSNGYSLVRKIVSLSGLAWDAPAPFGDGTVADLLMTPTRIYVKPLLKAIRETGAIKALAHITGGGFPENIPRVLPKPLAAEIDLDAIKPPAVFSWLAKTGGVAANEMLRTFNCGVGMIAVVSAGEAEKVAAVLAREGETVFTLGRMVSRSEDAPGTIYKGNLAI
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_SCHMA
Sequence: MGLSKLSISDVDLKGKRVLIRVDFNVPMKDGKVTNTQRIAAAIPTIKYALDKGAKSVVLMSHLGRPDGHKVDKYSLKPVCPEVSKLLGKEVTFLNDCVGPDVVNACANPAPGSVFLLENLRFHVEEEGKGVSPTGEKTKATADQIKAFSESLTKLGDVYVNDAFGTAHRAHASMVGCQLPQKACGFLMNKELTYFAKALENPERPFLAILGGAKVSDKIQLINNMLDKVNELIIGGGMAYTFLKQIHNMHIGNSLFDAPGAEIVHKVMETAKAKNVAIHLPVDFVTADKFADDANTEIRTIQSGIADGWMGLDIGPKTIEEFSKVISRAKTIVWNGPMGVFEMDKFATGTKAAMDEVVKATKNGATTIIGGGDTATCCAKWDTEDKVSHVSTGGGASLELLEGKQLPGVVALTDAH
What is the function of this protein?
Involved in the seventh step in glycolysis (PubMed:7477104).  Catalyzes the conversion of 1,3-bisphosphoglycerate ((2R)-3-phospho-glyceroyl phosphate) to 3-phosphoglycerate ((2R)-3-phosphoglycerate) and results in the formation of ATP (PubMed:7477104).  Associated with the tegument to provide the energy needed for the tegumental repair resulting from immune damage (PubMed:7477104).
What are the official names of this protein?
Phosphoglycerate kinase, PGK.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.