PharMolix/UniProtQA huggingface dataset:
Protein: SYA_METI4
Sequence: MMNSNEIRQSFLDFFKERGHTILPSASLVPESPNLLFTNAGMNPFVPFFLGKQKCPYVPPRIADSQKCLRAGGKHNDLEEVGYDTYHHTFFEMLGNWSFNDYFKEEAIHWAWELLTQKWGFPKERIYATVYKPAPDEPGEFDEEAFRIWFKLFQKAKLNPLLHIHFGTKKDNFWMMGETGPCGPCSEIHIDLTPDGQSEGKLINKNSPLCIEIWNLVFIQLNANEDGSFSLLPSRHVDTGMGLERVCAIIQGTSSFRQFNRTISDYDTDLFIPLIEKLQDISKVSYTGSIPPTPDFALDPQLKKDIAFRVIVDHVRALAFAIADGILPSNLGRGHVLRRLLRRAIRFGQILGVNPPFLFEMVDPLVKIMGSHYPELIDKQGHIEEVISSEEELFARTLSHGLALFEEIKQKMIAEKRKEISGKEAFVLYDTYGFPLDLTQLLAKEQGFSVDTQGFERLMAEQRRRSLLSHEEDIVSLTKTSQFVGYEELEAEAEVVVLLSANRAIFDRTPFYAEMGGQVGDKGYVVFDQKKIEVLDTMKSASGAHVHRLAFTDDLKPGSRVYLQVDEKRRRCIAAHHTATHLLHWALRKVLGPETLQRGSYVGPDRLRFDFSHTGPLSAEELAEIERLVNEKIELNDPVTAEEESYEKVKNNPDILQLFGEKYGQRVRIVSVGRYSKELCGGTHVRSTGEIGYFKILGEYGVSAGIRRIEAACGKALEQFLHAQAAEQDKKWQILHSKDPSLPRLSKWVDTLDLDSLIEIFQRRNEELSSFEKEIKEREKLRAKKQEENFRREASQQAMAAIAQVEKIGAIPVLFLDCDAKPQSYLPLLWNEISKRIDSVAILASRSEGKINLFIGVGPSLTTKIEARNLLSQLVASFEGKGGGSKTIAQGGLKDSIEISSLFEKGRGILEQYGGQKGQTEPKATG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH4_STAHJ
Sequence: MTEFDLSTREGRWKHFGSVDPIEGTKPTTKNEMTDLQSTHKNFLFEIEEVGIKNLIYPVNIDRFQTAGRFSFSTSLNKDEKGINMSRILESVEKHYNNGLELNFDTLYQVLRTLQTNMKQNSSGVDVSGKWFFDRFSPVTNIKAVGNADVTYGLAIEQDQITRKEITIEATVTTLCPCSKEISEYSAHNQRGVVTVKVYLDKNNQVVDDYKDKILDAMEANASSILYPILKRPDEKRVTERAYENPRFVEDLIRLIAADLVEFDWIDGFDIECRNEESIHQHDAFAKLKYRK
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: 1A_BBMV
Sequence: MSSFVNLESLISERGANCRGADEIVNNETTRILTSQIEHSQRSKKVNIRNKLSVAECDAFRARYGGAFDVNLTHEYTAPHSLAGALRVAEHYDCIDSFPPEDKIIDFGGSWLHHYSRGDSRVHSCCPILGPRDATRHEERMCRLRKMVQTSDRFVDVPDFCLNKAEDCNVQADWAICIHGGYDMGFQGLCKAMHAPLERGILQGTIMFDGAMLFDRQGELPLLQCRWQRVGTGSKEQIKFDFINESTLSYVHDWKNLGSFLTESTYSIGGTTYLLERMLLKCSIMTYKIIATNVRCPPESLRHCIWFENISQYLAVQIPIGYNLNDWKTVRVARATVREVEEISFRCFKENKDWTENMRSVASILSAKSSTVIINGQSIMSGERLDVLEYHLVAFSLTLNLYQKYEKLRNFQGELEWKGWANHFKTRLWWCGRTVSTEGGFLRNFLADKIPWLKLNTYADSLDFITKISEVESFEVDSVPTSRLRSFFQKEENIVERAASEIMSANARRIAKKAEMSKEFDDFVDAPEEFAPEDVVEEVINTPVTQDVKLRQSKPETARSIVLDPDAVLKNGAINEFADYSKRLHENTVSNLRHLWTLMGCRGNEIHNKSVAETYHRVDDMVNVHFPNGHWMYPLKYEYTVGYNDGGLGEKFENELYVVDKTCSCANAKAIADACKKVSAPTCSVVMVDGVAGCGKTTAIKETFRFEKDIIVTANRKSAEDVRKAIFGDASDSEVALKVVRTADSAIMHGLPECHRLLVDEAGLLHYGQLLAVADLCKCSEVLAFGDTEQISFKSRDATFRMKYCNIEYDKRDIVSKTFRCPQDVVSAVKILKRKCANRSSKYNGWVSSSKVEKSLSKSRIVSINQVSMEKHKFYLTMTEADKAALCSRAKDVGLDKTWVESNMETVHEAQGKAVDHVVLVRLKSTKCDLFKSEEYCLVALTRHKRTFEYLYNGDLGGDLISFYVT
What is the function of this protein?
Involved in the virus replication.  Contains a helicase domain and a methyltransferase domain.  The methyltransferase domain is probably involved in viral RNA capping.
What are the official names of this protein?
Replication protein 1a.
What is the protein family that this protein belongs to?
Belongs to the bromoviridae replication protein 1a family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: RS15_MARSD
Sequence: MVMTAEAKAKVIEEYQTKPGDTGSPEVQVALLTARIKYLTDHFKTHKKDFHSRTGLLKMVGQRRNILKYLKSKDVQRYRDLIARLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: DPO3A_NEIMB
Sequence: MTEPTYIPLRLHTEFSITDGMVRIKKLIAKAQEYGLPALGISDLMNEFGLVKFYKACRSAGIKPIGAADVRIGNPDAPDKPFRAMLIIRNDAGYLRLSELLTAAYVGKDRNVHHAELNPEWLENGDNSGLICLSGAHYGEVGVNLLNGNEDAARTAALKYAAWFPDAFYMELQRLPERPEWEACVSGSVKLAEELGLPVVATHPTQFMSRDDFNAHEARVCIAGGWVLTDKKRPRDFTPGQFFIPPETMAERFADLPEALENTVEIAKRCNLHITLGKNFLPLFPTPDGLSLDDYLIKLSNEGLQERMVQLYPDEAERAAKMPEYQERLDFELNIIIQMKFPGYFLIVQDFINWAKTHGCPVGPGRGSGAGSLVAYSLKITDLDPLKYALLFERFLNPERVSMPDFDVDFCQSNRGRVIEYVREKYGAEAVSQIVTFGTMSSKAVIRDVGRVLELPFMLCDKLSKLIPLEANKPLSLEKAMETEPQIQELIEAEEADELITLAKKLEDLTRGLGMHAGGVLIAPGKISDYSPVYQADESASPVSMYDKGDVEDVGLVKFDFLGLRNLTIIEMAQNNIKNTTGDIIDVGKIPLDDQVAYQIFRDANTTAVFQFESTGMKKMLKTAHTTKFEELIAFVSLYRPGPMDNIPDFVARMKGQEFQYIHPLLEGILAPTYGIMVYQEQVMQAAQIIGGYSLGGADLLRRAMGKKKPEEMVKHREIFAEGAAKQGISREKSDEIFNYMEKFAGYGFNKSHAAAYALISYQTAWLKAHYPAEFMAATMSSELDNTDQLKHFYDDCRANGIEFLPPDINESDYRFTPYPDMKIRYALGAIKGTGEAAVESITAARQSGGKFTGLLDFCERVGKEHMNRRTLEALIRGGAFDSIEPNRAMLLANIDLAMDNADQKAANANQGGLFDMMEDAIEPVRLIDAPMWSESEKLAEEKTVIGFYLSGHPFGPYAQEVRQIAPTKLDRLKPQDSVRLAGFVTAVRTMMGKRGKIAFVSLEDLSGQVEIMVGGQTLENCADCLKADQVLIIESKVSRDDYGGGDGLRILANQVMTLQTARERYARSLSLALAPHHDIGGLVRLLAAHQLPDTPRIPLQLSYANEKASGRLQVPPKWTVTPSSALFGELETLLGSRSVRVNW
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2365_LISMC
Sequence: MNPIVEFCVNNLASGADAAFAKLDADDSLDVIEYDCLTYCDLCATSLFALVDGEVVRGETAEELVANIYTFLEENPF
What are the official names of this protein?
UPF0349 protein Lm4b_02365.
What is the protein family that this protein belongs to?
Belongs to the UPF0349 family.
Protein: MREB_CAUVN
Sequence: MFSSLFGVISNDIAIDLGTANTLIYQKGKGIVLNEPSVVALRNVGGRKVVHAVGIEAKQMLGRTPGHMEAIRPMRDGVIADFEVAEEMIKYFIRKVHNRKGFVNPKVIVCVPSGATAVERRAINDSCLNAGARRVGLIDEPMAAAIGAGLPIHEPTGSMVVDIGGGTTEVAVLSLSGIVYSRSVRVGGDKMDEAIISYMRRHHNLLIGETTAERIKKEIGTARAPADGEGLSIDVKGRDLMQGVPREVRISEKQAADALAEPVGQIVEAVKVALEATPPELASDIADKGIMLTGGGALLRGLDAEIRDHTGLPVTVADDPLSCVALGCGKVLEHPKWMKGVLESTLA
What is the function of this protein?
Forms membrane-associated dynamic filaments that are essential for cell shape determination (PubMed:14982627, PubMed:17880425, PubMed:24843005).  Acts by regulating cell wall synthesis and cell elongation, and thus cell shape (PubMed:14982627, PubMed:17880425).  A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature (By similarity).  Required for mid-cell peptidoglycan synthesis and cell division.  Directs the localization of the cytosolic peptidoglycan precursor-synthesizing enzyme MurG (PubMed:17880425).  Also required for proper chromosome segregation (PubMed:15707892).  Directs the segregation of origin-proximal but not origin-distal loci (PubMed:15707892).
What are the official names of this protein?
Cell shape-determining protein MreB, Actin-like MreB protein.
What is the protein family that this protein belongs to?
Belongs to the FtsA/MreB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Membrane-associated (PubMed:14982627). Localizes as bands or spirals that encircled the cell along its entire length and switches to a mid-cell location at a time that coincided with the initiation of cell division. Localization at mid-cell depends on FtsZ (PubMed:14982627).
Protein: YCF3_BUXMI
Sequence: MSRSRINGNFIDKTFSIVANILLRIIPTTSGEKEAFTYYRDGMSAQSEGNYAEALQNYYEATRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYSRALERNPFLPQAFNNMAVICHYRGEQAIRQGDSEIAEAWSDQAAEYWKQAIALTPGNYIEAHNWLKITGRFE
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: PSBL_NICSY
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NRAM_I40A0
Sequence: MNPNQKIITIGSICMVVGIISLILQIGNIVSIWISHSIQTGNQNHTGTCNQSIITYKNSTWVNQTYVNISNTNVVAGKDTTSVILAGNSSLCPIRGWAIYSKDNGVRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDDGAVAVLKYNGIITETIKSWRKEILRTQESECVCVNGSCFTIMTDGPSGGPASYKIFKIEKGKVTKSIELDAPNSHYEECSCYPDTSKVMCVCRDNWHGSNRPWVSFDQNLDYQMGYICSGVFGDNPRPKDGKGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSNSSRQGFEMIWDPNGWTETDSNFFMKQDVVAVTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVDWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: HISZ_BURL3
Sequence: MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLSGRTLGLRADITPQVARIDAHLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLGHAGVLAALLARDAQAAERGESLYDALSGKDVPLLNELTDDLGADTRAALRALPHLYGDASVLAEARTRLPVLPEITRALDDLAQLAAQAKGAEVAIDLGDLRGYAYHSGAMFSAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLRELARISPVEARGTAILAPWAQDDALSAAVAALRDAGEVVIQALPGHDHVLDEFACDRSLVERNGAWVVEPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK36_CUSEX
Sequence: MKIRASVRQICDKCRLIRRRGRILVICYNPRHKQRQG
What are the official names of this protein?
Plastid 50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid.
Protein: ISPH_SYNSC
Sequence: MDTHAFKRSLHHSERYNRRGFGRAEEVAESLEQAYQSGLIGTIRDNGYRLEHGRLNVRLAEAFGFCWGVERAVAMAYETRKHYPSERLWITNEIIHNPSVNDHLREMDVQFIPVEQGVKDFSGVTSGDVVILPAFGATVQEMQLLNERGCHIVDTTCPWVSKVWNTVEKHKKHTFTSIIHGKVKHEETLATSSFAGTYLVVLDLEEAQYVADYILGNGDREDFIKRFAKACSPGFDPDRDLERLGVANQTTMLKSETEEIGRLFERTMLSKYGPTQLNDHFLAFNTICDATQERQDAMFSLVDEPLDLMVVIGGFNSSNTTHLQEIAVSRGIRSFHIDTPERIDVGSNSIEHKPLAADLCREGDFLPEGPVRVGITSGASTPDRAVEEVIEKLMQLSEN
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: 6PGD_MOUSE
Sequence: MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILKYRDTDGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFIHTNWTGHGGSVSSSSYNA
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_GEODF
Sequence: MRLKVLWVGKTQEEWVRRGIDEYAGRIGRYMSIDLAEARDEKGAAVEAMREREGERLLKLLPKNARLVLLDERGEQMSSPELARFLATNRDGGTQELVFVIGGAYGFSDSLRAKAFKTISLSRMTFTHQMVRIFLLEQLYRGFTIINGEPYHH
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 135R_IIV6
Sequence: MTKFTFSRFVIFSLFFTFISVSTFGNINFRFIVCKWTIFSFVALFYIFTHTSFTSLCFFGLRLFWHFFPRM
What are the official names of this protein?
Uncharacterized protein 135R.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TBC25_HUMAN
Sequence: MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQITSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLSEPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARALFADYLQSEVWDSEEGAEATAAS
What is the function of this protein?
Acts as a GTPase-activating protein specific for RAB33B.  Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.
What are the official names of this protein?
TBC1 domain family member 25.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, autophagosome. Note=It is dispersed in the cytoplasm under nutrient-rich conditions. Localizes at autophagosomes under cell starving conditions.
Protein: YBJL_ECOSM
Sequence: MNINVAELLNGNYILLLFVVLALGLCLGKLRLGSIQLGNSIGVLVVSLLLGQQHFSINTDALNLGFMLFIFCVGVEAGPNFFSIFFRDGKNYLMLALVMVGSALVIALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHSGMESRQLSLALDNLSLGYALTYLIGLVSLIVGARYLPKLQHQDLQTSAQQIARERGLDTDANRKVYLPVIRAYRVGPELVAWTDGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQMGDEIALVGYPDAHARLDPSFRNGKEVFDRDLLDMRIVTEEVVVKNHNAVGKRLAQLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKTIADRIGFISIHSQVTDLLAFCAFFVIGLMIGMITFQFSTFSFGMGNAAGLLFAGIMLGFMRANHPTFGYIPQGALSMVKEFGLMVFMAGVGLSAGSGINNGLGAIGGQMLIAGLIVSLVPVVICFLFGAYVLRMNRALLFGAMMGARTCAPAMEIISDTARSNIPALGYAGTYAIANVLLTLAGTIIVMVWPGLG
What are the official names of this protein?
Putative transport protein YbjL.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOA_BRUME
Sequence: MIQKNWQELIKPNKVDFITHGSRTHATVVAEPLERGFGLTLGNALRRVLLSSLRGAAVTAVQIDGVLHEFSSIPGVREDVTDIVLNIKEIAIRMEGEGPKRMVVHKEGPGVVTAGDIQTVGDVEILNPEHVICTLDEGAEIRMEFTVNTGKGYVPADCNRAEDAPIGLIPVDSLYSPVRKVSYKIENTREGQVLDYDKLTLNIETNGSVTGEDAVAYAARILQDQLSIFVNFEEPQKEAPQEQVAELAFNPALLKKVDELELSVRSANCLKNDNIVYIGDLIQKTEAEMLRTPNFGRKSLNEIKEVLASMGLHLGMEIPAWPPENIEDLAKRYEDQY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: Y2128_STRCO
Sequence: MRTLLITGPGGTGRTTVAAATALTAARQGTRTLVLGTDRDDTLGAALGVRTGPAPTSVEPGLTAWRPDAAQGFRDALAALQDRAASALDLLGAARLDPQELTPLPGADDLALLRALREAALAEAHDLLVVDLPPAPRALALLAAPEELRRALRRLLPPERQAARALRPVLGRLAGVPMPTEALYEAAARWDLELAAAESVLADRNTVVRLVAEPGPAGADAVRTTTLGLALRGLRTDLLVANRVLPEDTPADSWLSGPLAQQRKTLEEWRGAYDVRAVAHLGHDPRGTDDLAALAVPGVNPDASPVEWPVTDRLAEDGVLVWHIPLPGAVREELDLVRRGDELAVAAGPFRRTVPLPSALRRCTVDGAALRDGTLAVRFAPDPELWPRGR
What are the official names of this protein?
Uncharacterized protein SCO2128.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
Protein: RL9_STRP1
Sequence: MKVIFLADVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEATSQSIGELKGKQKAEEKAQAEILAEAQAVKAVLDEDKTRVQFQEKVGPDGRTFGSITAKKISEELQKQFGVKVDKRHIVLDHPIRAIGLIEVPVKLHKEVTAEIKLAITEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: HMGCS_ENTFL
Sequence: MTIGIDKISFFVPPYYIDMTALAEARNVDPGKFHIGIGQDQMAVNPISQDIVTFAANAAEAILTKEDKEAIDMVIVGTESSIDESKAAAVVLHRLMGIQPFARSFEIKEACYGATAGLQLAKNHVALHPDKKVLVVAADIAKYGLNSGGEPTQGAGAVAMLVASEPRILALKEDNVMLTQDIYDFWRPTGHPYPMVDGPLSNETYIQSFAQVWDEHKKRTGLDFADYDALAFHIPYTKMGKKALLAKISDQTEAEQERILARYEESIIYSRRVGNLYTGSLYLGLISLLENATTLTAGNQIGLFSYGSGAVAEFFTGELVAGYQNHLQKETHLALLDNRTELSIAEYEAMFAETLDTDIDQTLEDELKYSISAINNTVRSYRN
What is the function of this protein?
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA).  Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds.
What are the official names of this protein?
Hydroxymethylglutaryl-CoA synthase, HMG-CoA synthase, HMGCS, 3-hydroxy-3-methylglutaryl coenzyme A synthase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Protein: FZD8_RAT
Sequence: MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAATAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGGGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
What is the function of this protein?
Receptor for Wnt proteins.  Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.  The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  Coreceptor along with RYK of Wnt proteins, such as WNT1 (By similarity).
What are the official names of this protein?
Frizzled-8, Fz-8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus.
Protein: SCPB_MYCGA
Sequence: MKTKIKKITKKFNLKKDTEVKPLSTQELIEEQKEFSQAVDKLMTKKQKPTFEDIGSSIVDFETSDNDKFYESVRDAIEKTSEIVDDLDQSELTKNSYEQKELSAKAIIQAALYVAGRNGMTLQELNKILPKIHQDQLFKELEEMIYSYDQNLNFGLTIKNYGGRYKILTKAAVKKDMQRYVSERFKNPLNKSLMEVLAIVAYNQPCTRVRINEIRGVDSLSLVDNLLEKGLIVEVGRADTPGRPFLYNVSEKFFDLFGIESIDDLPQIKHFDPDSYQEGDFFDSNRYDENE
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.