PharMolix/UniProtQA huggingface dataset:
Protein: ATG7_AJECN
Sequence: MQYTPFASDIELPFYTSLASLKINHDKLDDSARKLLGLYEIRSTDRPEASCRMQIHGTALTRDEVPFGYYRAEGMIKNVNTIEEYHNIDRNALLLQTGKMIWDAINDETIYSCPSLLVSFIVLSFADLKKYKFSYWFAFPAIHSAPSWTSVMDPKPLTGNESSTLVDAVQTWRYGVDARQHGFFLARKDWHVVNSPSDGTVLNKAHVDNQQSLSPIAKELGFSWKISSISDFETGFFHDALPEDCFVCFADPSNYPDAPGWMLRNLLVLVRQRWKLNEVYILRYRDVQSKRDQGRSVVLKLRSDTAHLDPNDSRLGSQMPMPKVTGWERNAAGKLTGRVTNLTEYMDPRRLADQSVDLNLKLMKWRISPNLNLENIKNTKCLLLGAGTLGSYVARNLLGWGVRKITFVDNGTVSFSNPVRQPLFGFNDCLGGGAKKALRAAAALEEIYPGVDASGYVLSVPMPGHPITDASKAELEFKELKKLVDEHDAIFVLLDTREARWLPTVMGKATGKIVMNAALGFDTYVVMRHGVENCSAPETELGCYFCNDVVAPADSIKDQTLDQQCTVTRPGIAAIASALLVELFVSVLQHPDGPAAPASIPKQESRTDHPLGIVPHQIRGFLSNFSNVIVSGKSYNCCSACSGNIMDAYKNHGWDFVRKAVNERNYVEELSGLKEVSLSLKKRVVIGTKFHRSSV
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: GLYA_RICPR
Sequence: MNILNNNLYEMDKEIYEIIKNEKIRQNNVIELIASENFVSSAVLEAQGSILTNKYAEGYPSKRFYNGCDEVDKAEVLAIERIKKLFNCKYANVQPHSGSQANQTVYLALLQPCDTILGMSLDSGGHLTHGAAPNISGKWFNTVSYHVDQETYLIDYDEVERLAVLHNPKLLIAGFSAYPRKIDFAKFRKIADKVGAYLMADIAHIAGLVATGEHQSPIPYAHVVTSTTHKTLRGPRGGLILSDDEEIGKKINSALFPGLQGGPLMHIIAAKAVAFLENLQPEYKNYIKQVISNAKALAISLQERGYDILTGGTDNHIVLVDLRKDGITGKCAANSLDRAGITCNKNAIPFDTTSPFITSGIRFGTPACTTKGFKEKDFVLIGHMVAEILDGLKHNEDNSKTEQKVLSEVKKLMKLFPFYD
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPNE_DROPS
Sequence: MDQELMDFFDFSKEFVRKQAPRGHVSSNVHAFVTESEELEKPIKREIVGKDYVKSFVEKEKERMNGIFSSDEMAPMRNKSLDDMDSDEEYEASPEIRTDAEFYEKYYFNLNRDKSLPIYAKREEIINAINENPVVIVKGETGCGKTTQVPQYILDEGFKSKQYCNIVVTQPRRIAAISIANRVCQERQWQRGTVCGYQVGLHRQLERFADTRLLYCTTGVLLNILVNNKTLTHYTHIVLDEVHERGQEMDFLLIVIRRLLATNSRHVKVILMSATINPRELSDYFANERSAPPVIDASYGRNFTVEKYYRDQLQTINWEGHQEDINSPGITQEGYRSAIKTILVIDNMERNERSTGKSYNQSLREGSILIFLPGVGEINNMSDMLKDMANHDSIMKFNMVRCHSLMSSDDQREIFQPSPPGYRKIIMATNVAESSITVPDVSYIIDFCLEKVLFTDTFTNFSSLRLVWASKTNCRQRAGRVGRLRNGRVYRMVTKSFYQRELSEYSVPEMLRSPLQNCVLKAKELKMGTPVEMLALALSPPNLSDICNTILLLKEVGALFPTVDGTYDPCDGDITYWGTIMSKLPLDTRLSRLIILGYIFNLLDEAIIIAAGLTVRGIFVDSTRLGSDNYWMHYVFADGSGSDLVGIWRVYLTYLNMCENGLQKDASIQWAKRFHLSLRALSEMNLLVLDLRLRCEKLSLLPLNFPISRISDDSEKAIMLKVIIAGSFYPNYFVQSKSTSGDDRNMFSVISGLDPCRTVYFTSFTDRTMGELYTRKVKQLFPETQIPPENMDVTFGQGSEKIFVTFKNDIYKPEGTTYVHVPGRIKAEVYKALRLRTYCNHHSLRVMEPMSALKYVKDKKIGKVVEGRWIPPSKPVAVELLALPSVFDKIIVGRITNIVSCGKFFFQPESFENCIANMSEHFNNPQQLQNCVRNAGAITKGLMLLAKRQGKYQRATVVRVDTQNSSNVRFYVRFVDYGDIERLPMTQLRLMSQDLLRHYRDLPPRLFECRLALVQPASMVSTYNAWPQKADDMLHALAKGGRVQLEIYSLVQNVAAVMIHLREGNLNELLVKEKLARRTNEDYMSRVDHDFRMRKQECRGYVSQQERQQVNEEYLRSKQLPQDMDLSPPPPQECKSLIILKGPFSTLESTVFSTMQSGMSKTVRIDPCSVNFVLLDTEPQDQHAKMVVAASISSAGRHNDVLTLRSTSIMPNIPGFAAIMTLIFCPRAQLNANTANSRYVSILAGLGYHPQTMKSYYEDHDLVINLDVNIDEHDVLLINQIRYMMDSVFFNLEGELRPIAGHADRVLIHDTIYRALNRLLSKNRNFIVCNPKSSDYVWQDMEESGEPDPQPYGRRSIFPMHTIPELHEENMDTVLDLIANCKEMYDYRNFEGSFDPMTCRLCKQYLESVSELRLHLLTQLHLDREKEVGYPMD
What is the function of this protein?
Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons.  Involved in the repression of LTR retrotransposon copia.  Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements.  Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin.  Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats.  Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).
What are the official names of this protein?
Probable ATP-dependent RNA helicase spindle-E, Homeless.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis.
Protein: G3P_MOUSE
Sequence: MVKVGVNGFGRIGRLVTRAAICSGKVEIVAINDPFIDLNYMVYMFQYDSTHGKFNGTVKAENGKLVINGKPITIFQERDPTNIKWGEAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSNSHSSTFDAGAGIALNDNFVKLISWYDNEYGYSNRVVDLMAYMASKE
What is the function of this protein?
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:19903941).  Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:19903941).  Modulates the organization and assembly of the cytoskeleton (By similarity).  Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity).  Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094).  Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094).  Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity).  Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis.  Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, Peptidyl-cysteine S-nitrosylase GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Nucleus. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks.
Protein: RPOC2_NYMAL
Sequence: MEVLMAERADLVFHNKVIDGTAMKRLISRLIDHFGIAYTSHILDQVKTLGFQQATATSISLGIDDLLTTPSKRWLVQDAEQQSLILEKHHHYGNVHAVEKLRQSIEIWYATSEYLRQEMNLNFKMTDPSNPVHIMSYSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYTISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGSTRGISVSFRKGMTERIFIQTLIGRVLANDVYLGLRCIATRNQDIGIGLVNRFMTSRAQPIYIRTPFTCRSASWICRLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPSNGKIKFNEDLVHPTRTRHGHPAFLCYVDLYVTIESQDIIHSVNIPPKSFLLVQNDQYVESEQVIAEIRAGTSTFHFKERVRKHIYSDSEGEMHWSTGVYHAPEYTHGNVHFLPKTSHLWILSGGPCKSSLVPFSLHKDQDQMNVQSLSVQERSISDFSVNNNRVKHKLFGSDPLARKGRRISDYAAGSERVISNGDGDFIYPAILRENSYLLAKRRRNRFIIPFQYDPEWEKELTPHSSTSITVEIPANGILRRNSILAYFDDPRYRRSSSGITKYGIIEVDSIVKKEGLVEYRRPKESRPKYQMKVDRFFVIPEEVHILPGSSSIMVRNNSIIGVDTRITFNTRSQIGGLVRIEKKKKIELKIFSGGIHFPGETDKISRHIGILIPPGARKKMDKGSKGKNWEGNNWVYVQRITPIKKKYFVSVRPVVTYEIADGINLVTLFPGDMLQEKDNLRLQVVNYILYGDGKPIRGISHTSIQLVRTCLVLNWDQDKKGSIEKVQASSAEVRANDLIRYFIRIDLVKSPILYTGKRNDRSGSVIPDTGSYCANTNLFSSKVKIKSLSQHQGTVRTFLNRNKEGQSLIVFSSSNCSRINVSKYHNVTKESIKEKEDTPIPILNLLGPLGTVPKIHNFSPSYHSITHNEILLNKYLILDNKNPKQTFQLLKYYLVDENGRISNANPCSDIIFNLFGSCFLPHDYCEGTSTTRIISLGQFICENVCLSKHGTRIKSGQVIMVYLDSFIIRSAKPYLATRGATVHGDYGEIFYEGDTLVTFIYEKSRSGDITHGLPKVEQVLEVRSIDSISMNLEKRVEGWNEHITGILGIPWGFLIGAELTIAQSRVSLVNKIQKVYRSQGVQIHNKHIEIIVRQITSKVLVSEDGMSNVFSPGELIGLLRAERAGRALEEAICYRAVLLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGMIPVGTGFKRFVHRSREYNNIPLEIQKKNFFGGEMRDILFHHRELFCSCIPKPKSFHNTSEQPFYAMGSNPIVHKSGFIIS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NUOB2_CHLSY
Sequence: MGIEEKAGNLGIVTTTLETVVNWGRTNAMWPLLFGLACCAIEMMGAQASNYDLSRFGMELNRASPRQADLMIVAGRVSRKMAPVVRRLYDQMPEPKWVIAMGDCAACGGIFNNYAIVQGVDEVVPVDVYVAGCPPRPEALIDGIMMLHQKVMREKISGKKESPIRIDQPLVQVK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 2, NADH dehydrogenase I subunit B 2, NDH-1 subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DNAK_APHHA
Sequence: MGKVIGIDLGTTNSCFAVLEGGKPLVIENVEGGRTTPSIVAFTKEKERLVGQLAKRQAVTNAENTIYSIKRFIGRRWEDTEQERNRVSYHCVPGRDKTVDVKCWGKQYTPQELSAMILQTLKAGAEAYLNETVTEAVITVPAYFTDAQRQATKDAGTIAGLNVMRIINEPTAAALAFGLDKQEQREQVLVYDLGGGTLDVSILQLGDGVFEVKATAGNNHLGGDDFDNVIVEWMLSEFQAQEGINLNEDKMAMQRLREAAERAKIELSTRPTTSINLPFITAFSKGGGEVGPKHLKLNLSRAKFNELSRPLVEKTIDPLKQAIEDSGLSVDQIDRILLVGGSTRIPEVQEALKKFFNGKEPDRSINPDEAVALGAAIQGGVLGQEQEVEDLLLLVVIPLSLGIETLGEVFTKVIERNTTIPTSKSQVFSTASDGQTSVEIHVLQGERAMANDNKTLGKFLLTGIPAAPRGVPQIEVSFDIDVNGILKVSAEDKGTGREQGIVIKETGGLSQQEIERMQQEAEQYADEDRKRMQRIELSNQADSLFYSHEATLKDNQGLIPQKVKATANKKKEELMAILEDPNVELGVIQTRLEDYRQAVLSMGSEVYSQGSSKSSARDYETVGEEEMTRETGNSQESNAAFSTQPEGTVNNDNLELEAVFSTYNDHTQGSDVATSSHDEIDLGDASDNSQTNFDLDDEDFNPFEDFDEEEEASTDDYEAVE
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FNDC1_HUMAN
Sequence: MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW
What is the function of this protein?
May be an activator of G protein signaling.
What are the official names of this protein?
Fibronectin type III domain-containing protein 1, Activation-associated cDNA protein, Expressed in synovial lining protein.
What are the subcellular locations of this protein?
Secreted.
Protein: ORN_FRATO
Sequence: MQSADNLIWIDLEMTGLDVDSCKIIEIAAIITDKDLNIIAEAEPIAIYQPDEVLANMNEWCIKTHTETGLTQRVKDSKISTEAAEQQILEFIRKFVPYQSSPLCGNSIWQDRRFLAKYMPNIDEYCHYRMLDVTTLKLLNQYWGDGKSFEKKNTHKALDDIRESIAELKFYRQELLSI
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPTD_PSEA6
Sequence: MKPLKLELNPRDFNHYQAAFLPYRMKIKQPLHVLCFSVCSLSAVAQETCPAPANTFVVEKRLPNGQIQVISNMTSIQQDNFAEFEGDVEITNKDSQIIANKAQIDRTTQQLIATGDVSYQNPQLSVTSQKVLLNTQNNRMEIADTQYELTTLNARGQAELLVVDQTQGLELNGVTFSTCPTGQEDWLVHADSITVKPDETRGVARNAFFYVQDIPIFYLPYYSFPVTDARETGLLFPQVGSSSSTGFAYEQPYYLNLDPQYDATITPRYMTKRGLQLKTEFRYLTENNSGQIDIEYLPNDSDSTTNEDRYFYRFTHKGALSDDWEVNVDFNGLSDDNYIVDLGSDYYNSADTHLFRTLGLHYYSDALNVSLQLRDFEILGDHDDTYRALPELKLDYVTDLPAGFKFDIHSELARFDNANGTSPKATRAHIAPTLSLPLENSWGEFLAETSIMHTVYRQEDIEGTDLSRDVSRTLGQAKLYGALVFERQAHWFGDNVTQTLEPRAQYLYTSYEDQSDIGLYDTTRLFNDFAGLFRGQEFTGLDRISDKNQVTLGVTSRIIDEDNREQFKLSLGQIFYLEDNKVTAASKEDDRSALAAELDWRIGSKWLAHSEVQVSTQTDKVERSSVGLEYRLARDKMLQINHRFVRDLSGEQISQLGLTASWPIAQDWYWVGRWYRDIDRHRTIESYTGLQYESCCWALRIVAQRQLTSRFDDDGLQSTDEFDSGIAIQFLFKGIGGDSSGRDMLRDGLFGYRQPYLLD
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: RL11_MYCPA
Sequence: MAPKKKVVGLIKLQIQAGQANPAPPVGPALGQHGVNIMEFCKAYNAATENQRGQVIPVEITVYEDRSFTFALKTPPAAKLLLKAAGVGKGSAEPHKNKVAKVSWDQVKEIAETKKADLNANDIDAAAKIIAGTARSMGITVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: DPO4_SALTY
Sequence: MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRERRGVISTANYPARQFGVRSAMPTAMALKLCPHLTLLPGRFDAYKEASRHVRDIFSRYTSLIEPLSLDEAWLDVTDSPHCYGSATLIAREIRQTIFNELQLTASAGVAPVKFLAKIASDLNKPNGQYVITPADVPDFLKTLPLAKIPGVGKVSAAKLENMGLRTCGDIQQCDLAMLLKRFGKFGRVLWERSQGIDERDVNSERLRKSVGVERTLAEDIHEWSDCEAIIEHLYPELERRLAIVKPDLLIARQGVKLKFNDFQQTTQEHVWPQLNKEDLITTARKTWDERRGERGVRLVGLHVTLLDPQLERQLVLGL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACOHC_SOLTU
Sequence: EFYGGGMSGLSLADRATIANMAPEYGATMGFFPVDHVTLEYLKLTGRSDEIVGMVEAYLRANNMFVDYNEPQQEKVYSSYLNLDLADVEPCLSGPKRPHDRVPLKEMKSDWHALLDNKVGFKGFAVPKEVQDKVAKFSFHGQPAELKHGSVVIAAITSCTNTSNPSVMLGAALVAKKASELGLHVKPWVKTSLAPGSGVVTKYLLKSGLQKYLNQQGFNIVGYGCTTCIGNSGDLDESVASAISENDIVAAAVLSGNRNFEGRVHALTRANYLASPPLVVAYALAGTVDIDFEKDPIGVGKDGKDVYFRDIWPSTEEIAEVVQSSVLPDMFKSTYEAITKGNTMWNELSVPTTKLYQWDPKSTYIHEPPYFKGMTMDPPGPHGVKDAYCLLNFGDSITTDHISPAGSIHKDSPAARYLMERGVDRRDFNSYGSRRGNDEIMARGTFANIRLVNKLLNGEVGPKTVHVPSGEKLSVFDAAMKYKSAGQSTIILAGAEYGSGSSRDWAAKGPMLLGVKAVIAKSFERIHRSNLVGMGIVPLCFKAGEDADTLGLTGQERYTIDLPENISEIRPGQDVTVQTDTGKSFTCIVRFDTEVELAYFNHGGILQYVIRQLTQR
What is the function of this protein?
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
What are the official names of this protein?
Aconitate hydratase, cytoplasmic, Aconitase, Citrate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEP_I85A7
Sequence: MDSNTVSSFQDILMRMSKMQLGSSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQSRNGKWREQLSQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: MENB_BACSU
Sequence: MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMIDAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIRVIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARIVGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFLKAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP
What is the function of this protein?
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA synthase, DHNA-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
Protein: LEXA2_GEOSL
Sequence: METLTSRQRTVLEFITAHVDRHGYPPTMREIARHLNVNGTLGVAKHLEALARKGYLQREPGNSRGITLTGQTRHTPTVSLPVIGVVRAGVPQIATEEIEEHISIDQSLVKGGAFFLRVKGDSMINAAIIEGDLALVRPQQTAENRDIVVAMIDGEATLKRFYQGADHIRLQPENPNMAPIIVRSGVQEAWIIGKVVGIYRRMD
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: MNMA_PSEPF
Sequence: MRDPAPSDTSKKRVIVGMSGGVDSSVSALLLIEQGYEVEGLFMKNWEEDDGTEYCTAMDDLADAQAVCDKIGIKLHTANFAAEYWDNVFEHFLAEYKAGRTPNPDILCNREIKFKAFLDYAMMLGADLIATGHYVRRRDIDGRTELLKGLDPNKDQSYFLHAVGGEQIAKTLFPVGELEKPEVRAIAEKYELATAKKKDSTGICFIGERRFSDFLKQYLPAQPGEIKTTEGEVIGRHHGLMYHTIGQRQGLGIGGLKDAGDEPWYVLRKDLDTNELIVGQGNNHPWLFSSALLASEIYWVNPIDLSQPLRLTAKVRYRQSDQACTLEKTDTGYRAVFDEPQRAVTPGQSVVFYDGEICLGGGVIEVAEPWSGQA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPP7I_ARATH
Sequence: MPPPEISKRVLDSKLEACKFAFLKLSAVKTTRMKNYKQLRTLLMLKEISRRGADRDFLKDPENSVTRILCSVLKQVVSNSDRSLKSLRGFQYETLDDQEKQQVTRMIASVQGMGSRKYEPETVDHLEDMTEPIEMEIYLGNGDGGDFGDIVLEPISWPLESQLTLEWVETLMGLLNQSTWKNSVSEFSLILPHSVAVSLVDCASQILEKEANCVKINGCSEDSRVIVVGDLHGQLHDLLKIFDQSGRPSQNQCFVFNGNYIGRGSWSLEVFLVLLAWKIMMPENVILLRGSSETRVSAEELDFLKDICDRYGEHGPMLYSKCIDCFKMLPLASVISNSVYTTHGGLFQSCGVHEESPNPSLLLGSLEELDKIERRQAGENDDENITLNHVLWSCPWMADGLSESNYKGLLWGADCTETFLQQSNLKMIIRSHEGPDARADREDMGNMLSGYSIDHEVESGKLCTVFSASMFSQGSRNYENEGAYAVLEPPNFTEPVFVSYTVENVPRLQHQIISDGSSTQQQQMWENRTGHGFASMGISNPPSWTVPLPNDPSQILQLREPPQVFEGLPLPDNIQEPHKSNYDYLFRLISALKQEIQTRV
What are the official names of this protein?
Serine/threonine-protein phosphatase 7 inactive homolog.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-7 subfamily.