PharMolix/UniProtQA huggingface dataset:
Protein: ATPE_STRPS
Sequence: MAQLTVQIVTPDGLVYDHHASYVSVRTLDGEMGILPRHENMIAVLAVDEVKVKRIDDKDHVNWIAVNGGVIEIANDMITIVADSAERARDIDISRAERAKLRAERAIEEAQDKHLIDQERRAKIALQRAINRINVGNRL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ZAP70_HUMAN
Sequence: MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA
What is the function of this protein?
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response.  Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development.  Contributes also to the development and activation of primary B-lymphocytes.  When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane.  This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation.  Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK.  Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2.  In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.  Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC.  ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2.  Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface.  During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative).  Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR).
What are the official names of this protein?
Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity).
Protein: METE_SALA4
Sequence: MTILTHTLGFPRVGLRRELKKAQESYWAGNSTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNVPARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGIEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLLTTYFEGVTPNLDTIIALPVQGLHVDLIHGKDDVAELHQRLPVDWLLSAGLINGRNVWRADLTEKYAQINALVGKRALWVASSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSAPIQARRHSRRVHNAAVEKRLAAITAQDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRLWVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: RBE31_LITRU
Sequence: IEFFT
What is the function of this protein?
Shows neither neuropeptide activity nor antibiotic activity.
What are the official names of this protein?
Rubellidin-3.1.
What are the subcellular locations of this protein?
Secreted.
Protein: RL18_ECO55
Sequence: MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: LARP6_MOUSE
Sequence: MAQLGEQTLPGPETTVQIRVAIQEAEDLEDLEEEDEGTSARAAGDPARYLSPGWGSASEEEPSRGHSSATTSGGENDREDLEPEWRPPDEELIRKLVDQIEFYFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVTLELNEDHRKVRRTTPVPLFPNENLPSKMLLVYDLHLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVDAAIKAHEFMVTESQSKENMKAVLIGMKPPKKKPLKDKNHDDEATAGTHLSRSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAASNKLSPSGHQNIFLSPNASPCSSPWSSPLAQRKGVSRKSPLAEEGRLNFSTSPEIFRKCMDYSSDSSITPSGSPWVRRRRQAEMGTQEKSPGASPLLSRRMQTADGLPVGVLRLPRGPDNTRGFHGGHERGRACV
What is the function of this protein?
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2.  Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR.  This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity).
What are the official names of this protein?
La-related protein 6, Acheron, Achn, La ribonucleoprotein domain family member 6.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: EFG_BACHK
Sequence: MAREFSLENTRNIGIMAHIDAGKTTATERILYYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGHRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTIHDRLQANAHPIQLPIGAEDEFNGIIDLVEECAYMYGNDLGTDIQRVEIPEEHKELAEEYRGKLIEAVAELDEEMMMKYLEGEEITVEELKAGIRKATTSVEFFPVICGSAFKNKGVQILLDAVIDYLPSPLDVPAIKGIVPDTDEEVERKSSDEEPFAALAFKIMTDPYVGKLTFFRVYSGVLNSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEKSLVILESMEFPEPVISVAIEPKSKADQDKMGTALSKLSEEDPTFRAHTDQETGQTIIAGMGELHLDIIVDRMRREFKVEANVGAPQVAYRETFRAAAKVEGKFARQSGGRGQFGHVWIEFEPNEEGKGFEFENKIVGGVVPREYIPAVGAGLEDALKNGVLAGYPVVDIKAALVDGSYHDVDSSEMAFKIAASMALKAAVSKCNPVILEPMMKVEVVIPEEYMGDIMGDVTSRRGRVEGMEARGNAQVVRAMVPLSEMFGYATSLRSNTQGRGTFSMVFDHYEEVPKSVSEEIIKKNKGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HS17C_ARATH
Sequence: MSLIPSIFGGRRTNVFDPFSLDVFDPFEGFLTPSGLANAPAMDVAAFTNAKVDWRETPEAHVFKADLPGLRKEEVKVEVEDGNILQISGERSNENEEKNDKWHRVERSSGKFTRRFRLPENAKMEEIKASMENGVLSVTVPKVPEKKPEVKSIDISG
What are the official names of this protein?
17.6 kDa class I heat shock protein 3, 17.6 kDa heat shock protein 3, AtHsp17.6C.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAL_CLOBM
Sequence: MKIFIDTANVEEIRKASELGVLSGVTTNPSLIAKEGRDLKEVVEEICSIVDGPISAEVISLEHEKMIEEGRELSKLHKNIVIKIPMCEEGLKAVSVLSKEGIKTNVTLIFSSMQALLAARAGATYVSPFLGRLDDIGNPGIEVVEQIADMFKIHEIKTEIIAASVRTPMHVLEAAMAGSHIATIPYKVIIQMSKHALTDIGIEKFMKDYEKAFGENK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_BACCE
Sequence: MAREXSKENTR
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_AFIC5
Sequence: MARVTVEDCIDKVDNRFDLVLLAAHRARMISSGSPITVDRDNDKNPVVSLREIADQTIAPEDLKEELVHSLQKFVEVDEPEPDTIPLIGSAGASVDADDTEVAVERMTEEELLKGLEGLAPPEEQPEEEE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: ATPB_XANCP
Sequence: MSQGKIVQIIGAVVDVEFQRNEVPKVYHALKVEGTAITLEVQQQLGDGVVRTIALGSTDGLKRNLLATNTERAISVPVGAGTLGRIMDVLGRPIDEAGDVQASDHWEIHRAAPSYEDQSSSTELLETGIKVIDLMCPFAKGGKVGLFGGAGVGKTVNMMELINNIAKAHSGLSVFAGVGERTREGNDFYHEMKDSNVLDKVAMVYGQMNEPPGNRLRVALTGLTMAEYFRDEKDENGKGKDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKSGSITSIQAVYVPADDLTDPSPATTFAHLDSTVTLSRNIASLGIYPAVDPLDSTSRQMDPLVIGHEHYDTAQRVQQTLQKYKELKDIIAILGMDELSEEDKQSVSRARKIERFFSQPFHVAEVFTGSPGKYVSLKDTIRGFKAICDGEYDHLPEQAFYMVGSIEEAVEKANKMSAKA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GMHA_NEIG2
Sequence: MTTLQERVAAHFAESIRAKQEAEKILVEPTVQAAELMLQCLMNDGKILACGNGGSAADAQHFAAEMTGRFEKERMELAAVALTTDTSALTAIGNDYGFDHVFSKQVRALGRAGDVLVGISTSGNSANVIEAVKAAHERDMHVIALTGRDGGKIAAMLKDTDVLLNVPHPRTARIQENHILLIHAMCDCIDSVLLEGM
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_SODGM
Sequence: MTRQWPAPAKLNLFLYITGRRADGYHLLQTLFQFLDYGDTLTITPTADGRIRLMNPIAGVAEQDNLIVRAARLLQRHCFAAGDPAAPGADIQLEKVLPMGGGLGGGSSDAATVLVALNAQWLCGLDVATLAQLGLSLGADVPVFVRGEAAFAEGIGERLTPAAPAEKWYLVAVPPVSIATPRIFGDPELNRDAPQRSLAQLMTAPFHNDCEPIARKHFSAVEQHLSWLLEYAPSRLTGTGACVFAEFDTEAAARQVLSQAPAWMRGFVARGVNVSPLHRALSGAQ
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ADEC_METST
Sequence: MLIKGNILNVFTDEIYPGEIKIEHGIIESIKEVNADFNDIIVPGFIDAHIHIESSMLTPSRFAEIALRHGTTSVIADPHEIANVMGMDGIDYMIDDAKKTPLKYYFTAPSCVPATKFEKSGATISPNIIDNLLSRPEFVALGEVMDYNAVISNEKSILEKIKIAKKYHKPIDGHAPLLSGKNLQKYVKHGVITDHESTTKKEVAEKKRMGMKIMIREGSESKMLEKLIYSNCDFIVSDDLKPEDLINGHLDKCLRKAVDYGMDPYEAIKLVTINPAEHYNLNAGSISPGKSADLVFIDNLRDFTVKRVVINGNTIFKKQKLLFRANPRPIDTTLHVSLTKPEDFDLKAQNPAHKSATVNLINVSDNTIITKQSSAKLSIQKKTIIPSVFEDILKISVVDRYGGNTISNGFVKGFGIKNGAIASSVSHDSHNIIVVGTNSEYMSRATNHLIENKGGLAAISNQAKLDVTLPIAGLMSDKPAKVVANNSAKLNELVSNMGCELSSPFTSLSFMALPVVPEVKMTTNGLFNVNTHQFIDIIKEEK
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: YSL1_ORYSJ
Sequence: MADPAGAGGEQEAPSVEAAFAGQPPPPWWQQVTVRAVAVSVVLGTLFSFMAMRTGLTAGFVPSFNMSASLLSFFIIKSWTRLMARCGVASQPFTRQENVVVQTCVISCATLSIYGGFTSYLLAMNETVAKAAGGGTDGRNVYTLHTGKIVAFLFLVTFSSLFCTLPLRNTMIVDYKLIYPSGSAVAGIVNSFHTPKGATKAKLQVNAMFKSVAGSFAWAFFQWFYTGGDGCGFHAFPLFGLEAYKEKFYFDFSASLVGVGMICPHLINFSMLLGSISSSGFIWPALQAKQGEWYTDPSPTSFKGINGYKVPMGVSMVLGDCLFQLGAITVKAVQHYRKGRQEQKLAVDGAADDGGGGCVPDDDDENKWHATYDERRRNQVFLSDGIPDQFAVAGYVALAALSTALVPRIFPQIRYHHVAVCYAVAPLLAFCNSYTSGLMDWSLATVYGKLAIFVVGASVGAASGGVIAGLAACGVMMVVIGDAAELMHDFKTAYLTLTSPVSMFASQAIGTALGCVVNPAVFLAFRWLAGAEHPPGDPRSAYAAPMAVAYRGIAVLGVEGVGTLPRHAIALCAACFAAAVFLDTAGAAARAARWRVGGWVPNPMAMAIPFFVGPTFAIDMCVGSLLLMAWRRADRQGAATLAVVVASGLICGEGLWTLPSAVLAMLKVQPPICMKFLSRSQIQEVRQHFVLGAADIQPAVTLTHHHHQ
What is the function of this protein?
May be involved in the transport of nicotianamine-chelated metals.
What are the official names of this protein?
Probable metal-nicotianamine transporter YSL1, Protein YELLOW STRIPE LIKE 1, OsYSL1.
What is the protein family that this protein belongs to?
Belongs to the YSL (TC 2.A.67.2) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL23_LEPBA
Sequence: MNLENVILSPVVTEKSQDLQTIGERMGKRTVKYTFKVHPDANKTLIKQALKQMYNVVPTNVNVAVYRGKMKRFRNMPSQRPHYKKAVVTFADGANLDFAKV
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: DTR1_CANGA
Sequence: MSTSSNTSGECSPFSITDSIVVQATDDNADKILQEVDLSDPNIDKNDTFELRQQVSIKESPLYYLRDIPYSAYTSFQVSLIFLIVIYNGFLGPLAGNVFIPALPLLQKEFNVSETTINATVSVFMATFSISPLFWGALADKGGRKILYIISISLMVIINILLASVPKKIGSLIFLRIIQAFASSSVISLGAGTVADLTPPKDRGKAMAYFMLGPNLGPILAPIIAGLILLDNNNWRWLFGFLCIVSGLGLIMVILLLPETLRCIVGNGDRQWENWSQNENDMSTQPVDFSSPISRWSFVSDIGFLNPITQDSIFKGLYPHPPKFSVWTYLRIMTFPPVILTSIANALLFCTYYSISVTLSHFLATEYSYSNLKIGACYVCPGVCMLLGSQIGGHLSDSMRKSWKKENYNTEYPLEFRLILTVCGVLLAIGGSIGYGWCIQFHYHISAVLVFAGLMAFGLTWCNNTIMTYLSELLSLRVSSAIAVSSFFRNIAAAISSALIAKLCQKMGIGFCFLGLGLINLVSLFSILVLINNRNKWVKDSF
What is the function of this protein?
Plasma membrane acetic acid exporter, relieving the stress induced upon cells within hemocytes, and thus enabling increased proliferation and virulence against Galleria mellonella larvae.  Confers resistance to weak acid and oxidative stress, but not to antifungal drugs (PubMed:29184852).
What are the official names of this protein?
Multidrug transporter DTR1, Acetic acid exporter DTR1, Drug:H(+) antiporter DTR1, DHA DTR1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. CAR1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLMN_HAEIN
Sequence: MCNNEAKMSELLSVQSDAPAKKINLMDLTRQQMREFFKELGEKPFRADQLVKWIYHFGEDNFDNMTNINKKLREKLKAVAEIKAPEVAVEQRSADGTIKWAMQVGEQQVETVYIPEADRATLCVSSQVGCALACTFCSTAQQGFNRNLTVSEIIGQVWRASKIIGNFGVTGVRPITNVVMMGMGEPLLNVANVVPAMEIMLDDFAYGLSKRRVTLSTSGVVPALDNLSKMIDVALAISLHAPNDELRDEIVPINKKYNIKTLIDSVNRYLNVSNANHGKVTIEYVMLDHVNDGVEHAHQLAEVLKNTPCKINLIPWNPFPEAPYAKSSNTRIDRFQKTLMEYDFTVIIRKTRGDDIDAACGQLAGDVIDRTKRTAMKRQFGQNIGVTEVN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KATG_ECOHS
Sequence: MSTSDDIHNTTATGKCPFHQGGHDQSAGAGTTTRDWWPNQLRVDLLNQHSNRSNPLGEDFDYRKEFSKLDYYGLKKDLKALLTESQPWWPADWGSYAGLFIRMAWHGAGTYRSIDGRGGAGRGQQRFAPLNSWPDNVSLDKARRLLWPIKQKYGQKISWADLFILAGNVALENSGFRTFGFGAGREDVWEPDLDVNWGDEKAWLTHRHPEALAKAPLGATEMGLIYVNPEGPDHSGEPLSAAAAIRATFGNMGMNDEETVALIAGGHTLGKTHGAGPTSNVGPDPEAAPIEEQGLGWASTYGSGVGADAITSGLEVVWTQTPTQWSNYFFENLFKYEWVQTRSPAGAIQFEAVDAPEIIPDPFDPSKKRKPTMLVTDLTLRFDPEFEKISRRFLNDPQAFNEAFARAWFKLTHRDMGPKSRYIGPEVPKEDLIWQDPLPQPIYNPTEQDIIDLKFAIADSGLSVSELVSVAWASASTFRGGDKRGGANGARLALMPQRDWDVNAAAVRALPVLEKIQKESGKASLADIIVLAGVVGVEKAASAAGLSIHVPFAPGRVDARQDQTDIEMFELLEPIADGFRNYRARLDVSTTESLLIDKAQQLTLTAPEMTALVGGMRVLGANFDGSKNGVFTDRVGVLSNDFFVNLLDMRYEWKATDESKELFEGRDRETGEVKFTASRADLVFGSNSVLRAVAEVYASSDAHEKFVKDFVAAWVKVMNLDRFDLL
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: DNLJ_DESPS
Sequence: MLFCAGNPWLPAFFLQFVIMKKIDLTEKQRDLLVDVLDAEAGFAEEKLLDIASGAVSPLFLSESDLLSFLQAANALYRAGYPLLSDEAYDFTFLTELRRRNPQHPYLLQVEAEPVQQGKTVELPMRMLSTDKAYDLESIRRWGRRIEKAAQEKGIDFTSLVFRGTPKLDGFAAYDDGRRLYTRGDGKKGTDVSRAFARGLQVSRGGSRGLGAGEIVVNKDYFTEHLAQFFDNSRNFQASLIKEKTLALPVVKAIEAGAAIFFPFSMLPDWRGSWLELLQEFEEIVEGLWQKVPYEIDGVVFEIIDEGLREVMGATRHHHRWQIAFKKNTEIAEVTVLRVRPQTSRLGRVNPVAEVEPTRLSGALIQRVTAHHYAMVRDRGIGPGARIRMSRSGEVIPKIEEVVKPVAAAQLDIPAHCPSCGSDLAWDGDYLFCLNNMSCPAQITNSMEHFFKILGNVDGFGPSSVQRLYEGGLVDLPALYAMESADFEQVGFGPKQATNMVEQLNRSREELIEDWRFLAAFGVHRLGMGNCEKLLRYVRLEDVFNLSEEQIVAEIKGFQEKTAHSICAGLAGIKDLFFQLFALGFKLEPTPLLAEGGQGEKSPISGKTIVFTGAMLAASRGDMEKQAKALGATVGKSITGKTDMLVTGQRVGATKMAKAETLGIAILSEEAYRQLVSLD
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DAPF_BURM7
Sequence: MKLSFTKMHGAGNDFVVLDGYTRALPPLTGAQVRALADRHFGIGADQLLLVEKPTVDGADFKYRIFNCDGGEVEHCGNGARCFVKFVRDHGLTGKASVRVEVKHGVITLTMQDNGEVVVDMGAPVFEPARVPFDASGLDGRREGADTLWPLPVNGVTRWISVVSMGNPHAVQIVDDAEAFAVRVDGPAIERDPRFPQRVNAGFMQIVSRHEVNLRVYERGAGETLACGTGACAAVAAGIRRGRLDSPVTVHTHGGTLTISWNGACDERAPLMMAGPATTVFEGVIELPA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPHB_PSEFK
Sequence: MKLKGEAVLITGGASGLGRALVDRFVAEAKVAVLDKSAERLAELETDLGDNVLGIVGDVRSLEDQKQAASRCVARFGKIDTLIPNAGIWDYSTALVDLPEESLDAAFDEVFHINVKGYIHAVKALPALVASRGNVIFTISNAGFYPNGGGPLYTAAKQAIVGLVRELAFELAPYVRVNGVGPGGMNSDMRGPSSLGMGSKAISTVPLADMLKSVLPIGRMPEVEEYTGAYVFFATRGDAAPASGALVNYDGGLGVRGFFSGAGGNDLLEQLNIHP
What are the official names of this protein?
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase, 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase, 2,3-dihydroxy-4-phenylhexa-4,6-diene dehydrogenase, Biphenyl-2,3-dihydro-2,3-diol dehydrogenase, Biphenyl-cis-diol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: UPPP_SYNS9
Sequence: MIDTTAPLSLLEALVLGIVQGLTEFLPISSTAHLRVVPALLGWDDPGVSVTAAIQLGSVAAVIAYFRRDLTQVLTGISRAVRHGQWRDPDARLGVAMVIGTLPILVLGLGIKFFWHAGYASSPLRSVPSIAIVSIVMALFLAMAECMGPRLKQLGGVTGRDGFVVGLAQALAVIPGVSRSGSTLTASLFDGWNRADAARFSFLLGIPAISIAGLVELKSALSTSAGAGPLPLLVGIFSAAVVSWLAIDWLLRFLQRNSTWIFVGYRLVFGAGLLVWWAFKSAN
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAK_PSET1
Sequence: MGRIIGIDLGTTNSCVAVLDGGKARVIENAEGDRTTPSVIAYTQDGETLVGQPAKRQAVTNPTNTVFAIKRLIGRRFEDEEVQRDIGIMPFKIVKADNGDAWVEAGGEKRAAPQISAEILKKMKKTAEDFLGEAVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAYGMDKNRGENIVAVYDLGGGTFDLSIIEIDEVEGEHTFEVLATNGDTHLGGEDFDNRVINYLVAEFKKDQGLDLKTDPLAMQRVKEAAEKAKIELSSAQSTEVNLPYVTADATGPKHMNVKLTRAKLESLVEDLVTKSIEPLKRALADADLSVSDINDIILVGGQTRMPLVQKTVAEFFGKEPRKDVNPDEAVAVGAAIQGGVLAGDVKDVLLLDVSPLSLGIETMGSVMTALIEKNTTIPTKKSQTFSTAEDNQSAVTIHVLQGERKRSSDNKSLGQFNLEGIRPAQRGTPQIEVTFDVDADGILHVSAKDKDTGKEQKITIQASSGLSDEEVEQMIRDAEAHAEDDKKFEELVATRNQADAMVHGTRKQIEEAGDALPSEDKEAIEAAVVDLETAIKSDKKDEIEAKTQALAEKSQKLMEIAQAKAQQGSADAGEQQQSAKQDDDVVDAEFEEVKDDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.