PharMolix/UniProtQA huggingface dataset:
Protein: GAP1_YEAST
Sequence: MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC
What is the function of this protein?
General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981).  Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002).  Required for FLO11 expression and invasive growth (PubMed:22844449).
What are the official names of this protein?
General amino-acid permease GAP1.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Depending on nitrogen source, GAP1 is transported to the plasma membrane, where it functions for amino acid uptake, or to the vacuole, where it is degraded (PubMed:11500494, PubMed:11352928, PubMed:12499351, PubMed:12417748, PubMed:14523026, PubMed:15039776, PubMed:21471002).
Protein: IRS2_HUMAN
Sequence: MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEATAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFYGYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGAALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTFPASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTPPDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLEPQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPSLPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPRPSASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTYASIDFLSHHLKEATIVKE
What is the function of this protein?
May mediate the control of various cellular processes by insulin.
What are the official names of this protein?
Insulin receptor substrate 2, IRS-2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: KATG_CHAGB
Sequence: MGECPVNHANVAGGGTRNNDWWPNQLRLNILRQHQPASSPYSKEFDYAAAFKSLDYEALKKDITAVMTDSQDWWPADFGHYGGLFIRMAWHSAGTYRVFDGRGGGSQGQQRFAPLNSWPDNVSLDKARRLLWPVKQKYGDKISWADLLLLTGNVALESMGFKTFGFAGGRPDTWEADESAYWGGEKTWLGNDVRYGQGNEGVAGQGVVDGDESKKGHRDIHSRDLESPLAAAHMGLIYVNPEGPDGIPDPVAAGRDIRTTFGRMAMNDEETVALIAGGHTFGKTHGAAPAVNVSKEPEAAPLEQQGLGWSNKHGTGKGPDTITSGLEVIWTKEPTKWTHNFFEYLFKFEWELTKSPAGANQWVAKNTEPIIPDAFDPNKKHLPRMLTTDLALRFDPEYEKISRRFLENPDQFADAFARAWFKLLHRDLGPRSRWLGPEIPSEVLIWEDPVPAVNHPLVDEQDVTTLKRAILATGVAPAKLISTAWASASTFRGGDKRGGANGARIRLAPQKDWKVNNPPQLAEVLKALEGVQAQFNGASQSKKVSLADLIVLGGVAALEQAAGVSVPFTPGRTDASQEQTEVESFAHLEPHVDGFRSYGRGTSRVSTEQFLVDRAHLLTLTPPELAVLVGGLRVLGANYDGSSNGVFTTRPGKLTNDYFVNLLDMATAWKSVDGEVFEGNDRKTGEKKWTGTRADLVFGAHAELRAISEVYGSSSGQDKFVKDFVAAWSKVMNLDRYDLAQPGSSGPKL
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: V55B_HHV7J
Sequence: MSLATSDILKYVQIEIPYKEEFQGKDNVTLLFDEYVQSKTEPVLLLSAEINSRNSDSFFSARPLMEEQQLKLHLKNLNRHIYPSKVLFFGFPLLKINSSIVIIPNHDVKEQEQMGVFPSLIRFKNEKVIVTQTPHKVNEITVTMFNIEWKLSTYQRSIERTPGHPLTTLCTVCSVNINNLPFWFHDVRSGSDFPTCKVFSISDPTVSVLKMIFSPPLLEIYLRCYTEVTKNNTYMVPNDCMLKLGFVNEIIPNEISLTVHMHYFKICSDKRKIDVFFQDTMLFDEGETKKLHFKGTFYNFNANALYVPDPNSKVQSIASFWSPTTSFTTKVTSDRSQRVTTNDIIGSIYFIPTHILRTKFDPNYTDSFAAEIELNSEDPESDALYFLADKIFISDLPDLILRKGWSARKKKLQSGSNINNHAPSKSRLRF
What are the official names of this protein?
Uncharacterized protein U55B.
Protein: PSBX_GLOVI
Sequence: MTATLSNFLWSIFWGGVVVALGAAALTAISRIDRIR
What is the function of this protein?
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.
What are the official names of this protein?
Photosystem II reaction center X protein.
What is the protein family that this protein belongs to?
Belongs to the PsbX family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: Y1325_ZYMMO
Sequence: MSRNDLSSAPSSSAAPPARILLVTGLSGAGKSTALRTFEDMGWETVDNLPLSLLERLILTPPSSVAAYKGRPLALGIDSRTRGFTVDAFLKGVEQLRQHHSQPIDILFLDCSDSELMRRFDTTRRRHPLALDRPMEDGISEERAFLAPVREIADFLIDTTTTSSHSLQSELRQQFAPENSVAPNVSILSFGFSRGIPRNCDLLFDMRFLQNPYWEEALRPLTGLDPEIADYIEQDPSFLPAVTKIKDLLLFLLPRYIDTGKSYIVIAFACTGGRHRSVYVAEWIAARLRQAHFSLTITHRDLKLPLLESQSNRIRAGKAYQGG
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein ZMO1325.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: IMDH1_RAT
Sequence: MADYLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIQHGFSGIPITATGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDQDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGAQSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.  Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism.  It may also have a role in the development of malignancy and the growth progression of some tumors.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase 1, IMP dehydrogenase 1, IMPD 1, IMPDH 1.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL36_STRA5
Sequence: MKVRPSVKPICEYCKVIRRNGRVMVICPTNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: VSPJF_PROJR
Sequence: VIGGDECNINEHPFLVLVYY
What is the function of this protein?
Fibrin(ogen)olytic serine protease degrades Bbeta-chain of human fibrinogen (FGB) and shows a lower activity on Aa-chain (FGA).  Also degrades fibrin directly.  Releases fibrinopeptide B and a small amount of fibrinopeptide A.  Has also be shown to catalyze the hydrolysis of some chromogenic substrates such as S2238, S2160, S2302 and S2251.
What are the official names of this protein?
Beta-fibrinogenase jerdofibrase, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: H8D01_CYRHA
Sequence: MVNMKASMFLTFAGLVLLFVVCYASESEEKEFPKEMLSSIFAVDNDFKQEERDCAGYMRECKGKLCCSGYVCSSRWKWCVLPAPWRR
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U3-theraphotoxin-Hhn1l, U3-TRTX-Hhn1l, Hainantoxin-VIII-4, HNTX-VIII-4.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8) subfamily. Hntx-8 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DER_TRIEI
Sequence: MPLPIVAIIGRPNVGKSTIVNRLAESKDAIVHDEPGITRDRTYRNAYWEDREFQVVDTGGLVFDDNTEFLPLIREQAMAALVEASVAIFVVDGQTGLTGGDEEIAQWLRQQTIPILLAVNKCESITEGLTQAAMFWELGLGEPYPISGIHGNGTGELLDDLITYLPTQGEITETNQTKIAIVGRPNVGKSSLLNSFIGEKRAIVSPISGTTRDAIDTVVERNGKTYRLIDTAGIRKKKNVEYGAEFFGINRAFKAIRRAEVVMFVIDALDGVTEQDQKLANRIIEDGRACVIVVNKWDAIEKDNYTIYTYEQEVRSRLYFVEWAEMIFVSALTGKRVEKIINLIDNAANEYQRRVTTSVINEVLEEAISWNSPPTNRQGRQGKIYYGTQVTSKPPTIALFVNDPKRFPENYRRYIQSQFRQHLGFTGTPIRLLWRGKKAREVEQNTVNRATRV
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ATG2A_MOUSE
Sequence: MSRWLWPWSNCVKERVCRYLLQHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLETWSVNEFLRSMESPLELVEGFVSSIEVAVPWAALLTDHCTVCVSGLQLTLQPRQGSGPGAADSQSWASCMTTSLQLAQECLREGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLNTVVRVEHSLGDEDRSVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLSGVCLYFEELPSQADPPQPPLQIGSCTGYVELMVRLKQNEAFPGPKLEVSGQLGSLHLLLTPRQLQQLQRLLSAVNLADPAGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAESLSLYPITNPLNLDSTDLFFSMAGLTSSVTSAVSELSVYSVDLGSSVHSNMAFHRPSTPPHSGGKMAPTPLLDTTRPDSLVKMTLGGVSLTLLQTASPSSGPSDLPTHFFAEFDAAKDGPFGSRDFSHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSHSRRTSSTEVHFGQLEVLECLWPRAATEPEYTEILSFPSHSGSEASARPCAHLRHTQTIRRVLKSRSRRSTACHCHSELSLDLADFQSDVELGSLDRLAALFRQVTTPSEPPAGLLTEPPQATELQTVFRLSAPRATLRLRFPIPDLRPDRDPWAGQAVRAEQLRLELSEPQFRSELNSGPGPPAPTRLELTCSDLQGIYEDGEKPPVPCLRVSKALNPRSTEAKYFLPQVVVTLNPQSSGTQWETAYEKGRDLELSTESPCELQQPEPSPFSSKRTMYETEEMVIPGDPEEMRTFQSRTLALSRCTLDVIMPSAHIFLPSKEVYESIYNRINNDLLMWEPADLLPTSSAAARPPGSSGFKMCKSAFKLDSDSDEEDAQFFSMASGVPQTPAPEPSRRQSQSTFSTLVTVLKGRITALCEAKDETGKRLDVTHGELVLDVEQGTIFSVAQYRGQPGLGYFCLEAEKAKLYHRAAIEDYLLPTHLEVPSFAPPAQLAPTIYPSEEGVTERGTLGRKGQGPPMLSAAVRIHLDPHKNVKEFLVTVRLHKATLRHYMAPPEQSWHSQLLDFLDVLDDPVLGYLPPTVITVLHTHLFSCAVDYRPLYLPVRVLVTAETFTLSSNIVMDTSTFLLRFILDDSALYLSDKCEVESLDLRRDYVCVLDIDLLELVIKTWKGSTEGRLSQPLFELRCSNNVVHVHSCADSCALLVNLLQYLTSSGDLHPPPRPPSPTEIAGQKLSESPASLPSCLPVETALINQRDLTDALLDTERRGLQELAQSSGGPLPQASPVSVYLFPGERSGAQAPLPPPGASSHTLGSKAKEHENEEEGDGDTLDSDEFCILDAPGLGIAPRDGEPIVTQLHPGPIIVHDGHFSQPLGSTDLLRAPAHFPVPSSRVVLREVSFIWHLYGGRDFGLHPTYRARVGLTGPRVSPSRSSGPNRPQNSWRTQGGIGRQHQVLMEIQLSKVSFQHEVYPEESAIAGGLGQELDERPLSRQVLIVQELEIRDRLATSKINKFLHLHTSERLPRRTHSNMLTIKALHVAPTSSVGGPECCLRVSMMPLRLNVDQDALFFLKDFFTSLAASINPMVPGDTSEAPRETHSRPGSPQEGQSEDTETASNPPEAPGSSHSSSDQQPIYFREFRFTSEVPICLDYHGKHVTVDQVGTFMGLLIGLAQLNCSELKLKRLCCRHGLLGVDKVLCYALNEWLQDIRKNQLPGLLGGVGPMHSVVQLFQGFRDLLWLPIEQYRKDGRLIRGLQRGAASFGSSTASAALELSNRLVQAIQATAETVYDILSPASPVSRSLQDKRSSRKLRRGQQPADLREGMAKAYDAVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPIIVATEATSNVLGGMRNQILPDAHKDHALKWRLEEAQD
What is the function of this protein?
(Microbial infection) Mediates the intracellular lifestyle of Cryptococcus neoformans by supporting infection.
What are the official names of this protein?
Autophagy-related protein 2 homolog A.
What is the protein family that this protein belongs to?
Belongs to the ATG2 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Localizes to endoplasmic reticulum-autophagosome contact sites.
Protein: LPTD_ACIAC
Sequence: MDLSSLPDPLRPTHSRLPARRRDRAEPPRFEQRALARLAAWMVCGLPLAALAQTDPGPGATAEPAPALRSSPLLQEKIPEDARPKLPIFVRGDHVSGQPDINATVEGNAELRRGDTIIHADRLDYAVPDDLAKARGNVRINRAGNVYEGSVLELQVDAFSGFFDDASYRFLANGAYGDARRVDFIDRDRALVHEATYTTCQKNDESTWKPAWIVRARSIKIDNAEQVGTAEGGVLEFQGVPILPVPGSFTFPLSDKRKTGLLPPTVGIDSVSGVVYSQPYYWNIAPNRDATITPMVMSKRGVSTSGEFRYLEPTYSGELRGDYMPSDRLRNRDRWALGLKHRGVFDTGIGGIGLNVDATRVSDDNYWRDFSTRTNGGISQLTQRLLPADATLFWGANDMSLSLRTLKWQTLQDVNARIVPPYDRMPQIHWGYMPSSLPGGFDGSVEADYTDFRADRALTGQPNARRSYAMAQFSRPFLAPAGFITPRLQFHATQYDFDSALPSTGRRTASRVLPTFSLDSGLVFERDARYFGRNFLQTLEPRAFYTYTPFRDQSMIPVYDTAANDFNFATIYTENGYSGSDRIADNNLLTLGVTTRLLDPEDGGEAARFGIAQRLRFSDQKVVMPGEAPVSERLSDVLVGAGINWTRQWGFDSTVQYNPKTSRSIRSTIGARYNPSDYRVINAAYRFQRGTSEQIDVGWQWPINDLWGDKGQNLGPGRGQGGGRWYSVGRLNYSLQDRKLVDTVIGFEYDSCCWIGRVVLERLQSSVTTATTRLLFQIEFVGFSRLSLGSDPIQTLKQNIPRYQYLREPVPPPSRFTNYD
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
Protein: LIPB_PSEE4
Sequence: MSGVLGIRDLGLQPYEPVLEAMRRFTEQRGPESQDEVWLVEHPPVFTQGQAGKAEHLLIPGEIPVVQTDRGGQVTYHGPGQLVAYLLLDVRRLSIGVRELVSRIEQTLIDLLASYGVQAVAKPDAPGVYVDGAKIASLGLRIRNGRSFHGLALNVDMDLAPFRRINPCGYAGLAMTQLRDLAGPIELDEVRTRLRGQLVRHLDYAEQTTLTGGID
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1589_STRP7
Sequence: MKILIPTAKEMNTDLPSIEAIPLKPESQTVLDALALYSASQLESFYKVSAEKAAEEFQNIQALKRQTAQHYPALKLFDGLMYRNIKRDKLTEAEQDYLENHVFITSALYGVVPALSPMAPHRLDFLMKLKVVGKTLKSHWKAVYDEALKKEEVIFSLLSSEFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARRLNFAGFVYREDLSQPQGLVFVKEV
What are the official names of this protein?
UPF0246 protein SP70585_1589.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: CDC20_RAT
Sequence: MAQFVFESDLHSLLQLDAPIPNAPIARWQRKAKEATGPAPSPMRAANRSHSAGRTPGRTPGKSNSKVQTTPSKPGGDRYIPQRSASQMEVASFLLSKENQPEDGGTPTKKEHQKAWARNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKACRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQLLQMEQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKRLRNMTSHSARVSSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNIVNVWPSGPGESGWVPLQTFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGACLSAVDVHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTARVLSLTMSPDGATVASAAADETLRLWRCFELDPALRREREKASTSKSSLIHQGIR
What is the function of this protein?
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex.  Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates.  The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons.  CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity).  Interacts with NEK2 (By similarity).
What are the official names of this protein?
Cell division cycle protein 20 homolog, p55CDC.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CDC20/Fizzy family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Protein: M7F_CONCN
Sequence: MKLTCVVIVAVLLLTACQLITADDSRGTQRHRALRSDTKLSMSTRCKGKGASCSRTMYNCCSGSCNRGKCG
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-conotoxin-like CnVIIF.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EX7S_GEOMG
Sequence: MAVEKFETALKKLEDVVNRLESGELSLDDSLKAFEEGVKMAAFCTKKLDEAEKKVEILLKKKDGSFAKEPFRLEDD
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGDG1_LOTJA
Sequence: MASQRQPPSSSNAFSFLSKGWREVRDSADADLQLMKDRANSFKNLATSFDRELENFFNSAAPAFSVPAMRSASPPPAEIEFVKKLQPKLSEFRRAYSSPDFSKKVLEKWRPRARIRIDLSAIKNAIVSEEIDEGIVDFERGKRERRLSFWEELKGEGEAQDWEPIRALKTRLKEFEKRSSSVEFFDGFKNSEFLEKVKSSLKSMCKEPRDSKEVPPLDVAELLAYFVKQSGPFLDQLGVRRDVCDKIVESLYSKRKNQLLLPSLSGEESSLLGNGNINDELDLRIASVLQSTGHRNEGGFWTDHAKHDLSDNERHVAIVTTASLPWMTGTAVNPLFRAAYLSQSEKQKVTLLVPWLCKSDQELVYPSNLTFTSPEEQEGYIRNWLEERIGFKADFKISFYPGKFSQARRSIIPAGDTAQFIPSKDADIAILEEPEHLNWYHHGTRWTDKFNHVVGIVHTNYLEYIKREKNGALQAFLVKHINNWVARAYCDKVLRLSAATQDLPKSVVCNVHGVNPKFLKIGESIAAERELGQKGFTKGAYFLGKMVWAKGYKELIDLLAKHKADLDGVKLDVFGNGEDANEVQSAARRFDLNLNFQKGRDHADDSLHRYKVFINPSISDVLCTATAEALAMGKFVVCADHPSNEFFRSFPNCLTYKTPEDFAVKVKEALANEPYPLTPEQRYQLSWEAATQRFMEYSELDKVLNKEKDGAKPSKNNRKIMAKSASMPNLTELVDGGLAFAHYCLTGNEFLRLCTGATPGTRDYDKQHCKDLNLLPPQVENPIYGW
What is the function of this protein?
Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid membranes.  Specific for alpha-glycosidic linkages.
What are the official names of this protein?
Digalactosyldiacylglycerol synthase 1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
What are the subcellular locations of this protein?
Symbiosome, peribacteroid membrane. Plastid, chloroplast outer membrane.
Protein: YIDC_TREDE
Sequence: MKKNTVLAVVLSMLVFGGWLYIQQKYFPTEYNVPQKPVAQAQGQNPTSSEIAVQTSSNQISNSMIEAVADSDYPSREQTYVIETDIIRAVFTNKGGDIISYKLKEHASAGSDERVEMIENVTERNRALSLALGGHDAQAVDLLFNVKEESLSDGRKQIGFYRDIKLKNTDGSETVFTLAKRYTFIPGDYMFTLEVTIDGKEGMRGLSFGDSAYTLRSAPQIGPEWDKVNDKYEYRALSYFANEKKKEDRSITDGKTKAVNDLASWVSVSGKYFSFIIIPKDPIQKMFFSGIKEEGAKLHNSQFFISRQPIVGNAAYDQYRVYIGPSSEKILNSYNSAAANNYGYENLRIDSLAASSGFLAPLERVLKFVMEIFYKIIPNWGVALLLLTLLMRIIFFPLTKKSSEATKRMQELQPQINELQQKYKNNPQKLNAEMVKFYKEAGYNPASGCLPLLIQLPFLFAMFGLFNNYFEFRGASFIPGWIPDLSVGDSILKFGFTIPFLNWTDLRLLPIIYTASQLLHGKLTQTPGQSQQNPSMKIMIYFMPLFFFFLFYNAPSGLLLFWTFSNILMLLQQLIINKSMKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WFDC5_PONAB
Sequence: MRIQSLLLLGALLAVGSQLPAVFGRKKGEKSGGCPPDDGPCLLSVPDQCVEDSQCPLTRKCCYRACFRQCVPRVSVKLGSCPEDQLRCLSPMNHLCHKDSDCSGKKRCCHSACGRDCRDPARG
What is the function of this protein?
Putative acid-stable proteinase inhibitor.
What are the official names of this protein?
WAP four-disulfide core domain protein 5.
What are the subcellular locations of this protein?
Secreted.
Protein: JHD1_DROME
Sequence: MSTAVETGSSPAKSNSNNSSSGGNNNNGNGNLSPNAKGVQRRQLRERKQRKLYLEEWSLGDEDGEGTRGFSVAEKLESSKFAQAGMVREMRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHTHLTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCKDQQDLAITGVSVLKSPPGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESDTSQSTGVGSVIGMGAGVEYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHLATALVAAAASSSSGGGGPVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGGILNMDNCHSPEGGGAKLSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAKQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCALSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVSHGQGGAEGHADGNTLLPPPVGQYNDFVFTSESEMESGTVSGHMTHWKHGMKRHHQLEVKTERNNSCDTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMHESNDAPCGSSAEGAGGAGNANVSTNQWSGSGGGGGSRKKNSIRSQLAQQMLNSSTRVLKKPQYVVRPASGTGSSSSSGNGGSASATNGISNGSNQSGANSCGAGNGERGTNNGGLSGSNGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKMNCSEHKMSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYITQSLPYLRHLDLSSCQRITDAGVAQIGTSTTATARLTELNLSACRLVSENALEHLAKCEGLIWLDLRHVPQVSTQSVIRFASNSKHDLCVRDIKLVERRRRNSTTANRSWHHD
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
What are the official names of this protein?
JmjC domain-containing histone demethylation protein 1, Lysine (K)-specific demethylase 2, [Histone-H3]-lysine-36 demethylase 1.
What is the protein family that this protein belongs to?
Belongs to the JHDM1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL6_HAES1
Sequence: MSRVAKAPVSIPASVEVKLDGQLLTVKGKNGELSRTIHNSVEVKQDNNQLTFSPRVGIANADAQSGTARALVNAMVIGVNEGFTKKLQLVGVGYRAQMKGNVLVLSLGFSHPIDHVLPAGVTAECPSQTEIVLKSADKQLIGQVAADIRAYRRPEPYKGKGVRYADEVVRMKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RS19_BORBU
Sequence: MARSIKKGPFIEKSLYQKVLSSFGSEKRVVIKTYSRSSTIIPEMVSLTISVYNGKTFIPIYITEDLVGHKLGEFSPTRIFRGHAKSDKKGRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.