PharMolix/UniProtQA huggingface dataset:
Protein: SPRT_ECO81
Sequence: MKTSRLPIAIQQAVMRRLREKLAQANLKLGRNYPEPKLSYTQRGTSAGTAWLESYEIRLNPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMESVLGVPARRTHQFELQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAVYRCVHCGEQLVAK
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMC2_PLAF7
Sequence: MYIEEIILDGFKSYPTKTVIGPFHPQFNAITGLNGSGKSNVLDAICFVMGINNLNLIRVNRLDELIYKQGQAGITKGSVTIKFNNEEKPSPLQEPYRDMKNITITRQIVLGGRNRYLLNSHNAKPKDISDFFQSLKLNINNPHFLIMQGKITKVINMKPIELLGLIEESSGTKLYEVKRTNAIKLMVKKDQKLGEINKVLFEEIEPTLVKLKKEKEEYNKFVSNNEEIEKYEKVEIAYKYYVAKKMMTKCEEKIEDAKSEEKILEKGIKEIDKDIEKYKIEKEKIVKETNTASEPMKILISQKEELEKKISQLKSEAKMENKEKAKEKRRREDIKKEINNLQNKLDDYQKNNEKNNKNLKSYEDLKKKIEILKEELNEKQLTMNCLLSAGTNNNEYTGSFREQLKNYKTNLSKAETQINNFLQNNKHLEKEIMTLKEQRKKYEKEYNEISKEKDIEEKKKKLCEQELDKLNKEYNNFMELDTLKTDKNILYNDMEKLQQELQVLKNIINSVKIDYKIPSNMKSTDVLGQIYKLIKIKKEYINTALAVHLILGGKLTYLLVQNKEHSKRLFEYNNFSSGSKRVTLLPLEDCVISREVHEKHIEECRRNVGLNIKDKNDVIYFLDIMEYDKNLERIIQYLFNGTLICSNVDLCKKITYNPNKKLSYTTITLEGDKFDTSGSMSGGSNKNINLFLLNYEKYKHKKEQYHDNENKLKEVSEKLKSLEKAEEKKKIISKELQIYENNLNNIENRMETSKYGSVNKKIEEHKNEIDKGRNELSELYKEQKKLTEVIRKLEKDISEYEANKDKKEEDLKETIKKLKNKIKQLETEEHKKKEEIDDVLLQIENYKKQKEKETNDLSSTDEIINEIEKKIEDIEKNINITKENLKELENKITELQSSFSSYENEMKHVVKKIEDLEKKKSENILDLKKLENTLLDLQKDLKTSSDTVKYLYKTHVWIESYEPLFNKKYTPYDFENFRHDVIQKKIQALQNEQNKLSININRKAVQMYEQVQVDYKDLVTKKSQVEEDKKKIQEVIADLDVKKSESLLAMYQQINEYFQAIFSTLLNNAQAKLSIVDGDLANGIEMKIAFNNNWKESLTELSGGQRSLLALSLILALLKVRTVPMYILDEIDAALDLNHTQNIGDMIRTQFPHSQFIIVSLKEGMFSHADVLFKMRFIDGISTVNRHALDIRQNTNKKEVQEVKRRRVTIHDKEPDHD
What is the function of this protein?
May play a role in the conversion of interphase chromatin into condensed chromosomes.
What are the official names of this protein?
Structural maintenance of chromosomes protein 2.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRPD_YARLI
Sequence: MRAFRSAANFGAASNIYRKSFTPASIASNRFVSARMSSIMTDNARPNTDKVVQDIADYIHDYKIDSSVAMETARLCFLDTLGCGLEGLKYQQCANIVGPVVPGTIVPNGTKVPGTDYQVDPVRGAFNIGTIIRWLDFNDCWLAAEWGHPSDNLGGILAVADWQTRSAKAGLEGKVFKVKDVLEGMIKAHEIQGGLAIENSFNRVGLDHVVLVKIASTAVVSGMLGLSREQTADAISQAFVDGQSLRTYRHAPNTMSRKSWAAGDATSRAVNLALLVKKGEGGMPSILTAKTWGFYDVLFGGKEFKFQRPYGSYVMENVLFKISFPAEFHAQTACESAMLLHEELKKLGKTSDDIASIKIRTQEAAMRIIDKKGPLHNYADRDHCIQYMVAIPLIHGRLTADDYTDEIASDPRIDALREKMECVEDKRFSEEYHAPDKRYIGNAIEITLKDGTVLDEIEVNYPIGHRQRREEGTPVLLEKFARHLRGRFPEGQVEKILAASNQDIVNMDIDEYVDLYVKKD
What is the function of this protein?
Component of the methylcitrate cycle that catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate.  The methylcitrate cycle is a metabolic pathway for the consumption of propionic acid.
What are the official names of this protein?
2-methylcitrate dehydratase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PrpD family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL3_TOLAT
Sequence: MTLGLVGRKLGMTRVFTEDGVSIPVTVIEVEANRVTQLKTLETDGYTAVQVTTGVKKASRLTKAEAGHFAKAEVEAGRGLWEFRLNDGEGADLTVGSELKVDIFADVKKADVTGISKGKGFAGVVKRWNFRTQDMTHGNSRSHRVPGSIGQNQSPGKVFKGKKMAGHLGCERVTVQSLDIVRVDVERNLLLIKGAVPGATNGDVIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: MGP_HUMAN
Sequence: MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGTK
What is the function of this protein?
Associates with the organic matrix of bone and cartilage.  Thought to act as an inhibitor of bone formation.
What are the official names of this protein?
Matrix Gla protein, MGP, Cell growth-inhibiting gene 36 protein.
What is the protein family that this protein belongs to?
Belongs to the osteocalcin/matrix Gla protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS7_TERTT
Sequence: MQERKAAVNRDTLETQISVALNLDGTGAAAFATGVPFLEHMMDQIARHGMIDLDVRCQGDTHIDDHHSVEDIGITIGQAMHQAVGDKRGIRRYGHAYVPLDEALSRVVIDFSGRPGLEMHIPFTQKRIGSFDTELFWEFFQGFVNHAGVTLHIDCLRGHNAHHQIETVFKAFGRALRMALEVDPRMGNAMPSTKGTL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_THEVB
Sequence: MAIDPYRHLLRPLLFSGLQADPELLHQQFLSLCGWLNQDRSLCTWLRQQLQQWYALSDPRLERQVWGLRFPNPIGLAAGFDKNGVARSVWSAFGFGFAELGTVTWHPQPGNPRPRLFRLGSDRAVINRMGFNNAGAEAMAASLERSPPASIPIGINLGKSKITPLAAAKEDYLASFRRLHPLGDYFVINVSSPNTPGLRDLQAKEQLAPILETLQSANHPRKPLLLKIAPDLSWEQIAAILDLVQAYELAGIVATNTTVAREGLKSQTIPQTGRSPAEEAGGLSGAPLRQRATAVIRFIHEQTQGTLPIIGVGGIFTPEDVIEKLAAGATLVQLYTGWIYQGPSLLRELLKGLLAAADQETPEK
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DUSA_ECOLI
Sequence: MHGNSEMQKINQTSAMPEKTDVHWSGRFSVAPMLDWTDRHCRYFLRLLSRNTLLYTEMVTTGAIIHGKGDYLAYSEEEHPVALQLGGSDPAALAQCAKLAEARGYDEINLNVGCPSDRVQNGMFGACLMGNAQLVADCVKAMRDVVSIPVTVKTRIGIDDQDSYEFLCDFINTVSGKGECEMFIIHARKAWLSGLSPKENREIPPLDYPRVYQLKRDFPHLTMSINGGIKSLEEAKAHLQHMDGVMVGREAYQNPGILAAVDREIFGSSDTDADPVAVVRAMYPYIERELSQGTYLGHITRHMLGLFQGIPGARQWRRYLSENAHKAGADINVLEHALKLVADKR
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.  Specifically modifies U20 and U20a in tRNAs.
What are the official names of this protein?
tRNA-dihydrouridine(20/20a) synthase, U20-specific dihydrouridine synthase, U20-specific Dus, tRNA-dihydrouridine synthase A.
What is the protein family that this protein belongs to?
Belongs to the Dus family. DusA subfamily.
Protein: CLPP_CLOBM
Sequence: MSLVPVVVEQTNRGERSYDIYSRLLKDRIIMLSEEVNDTTASLIVAQLLFLEAEDPDKDIHLYINSPGGSITSGMAIYDTMQYIKPDVSTICVGMAASMGAFLLVAGAKGKRYALPNSEVMIHQPLGGFQGQATDIGIHAERILKMKKKLNTILSDRTGKPLEQVELDTERDHFLSAEEAKEYGLIDEVIDKKK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_RICBR
Sequence: MPKRVLQGVVISSKTDKTVTVKVERRFKHPIYKKFIKVSKKYAAHDPNNKFQEGDKVNIIESRPISKTKTWVVINEE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: NIKR_ECODH
Sequence: MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel.
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: GALE_BOVIN
Sequence: MAEKVLVTGGAGYIGSHTVLELLEAGYSPMVIDNFHNAIRGGGSMPESLRRVQDLTGRSVEFEEMDILDQAALQRLFKKHSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKAWNAVLLRYFNPIGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREVLNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLALKELGWSAALGLDRMCEDLWRWQKQNPSGFGTQA
What is the function of this protein?
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.  The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate.  It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited.  Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
What are the official names of this protein?
UDP-glucose 4-epimerase, Galactowaldenase, UDP-N-acetylglucosamine 4-epimerase, UDP-GlcNAc 4-epimerase, UDP-galactosamine 4-epimerase, UDP-GalNAc 4-epimerase, UDP-galactose 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: SUR2_YEAST
Sequence: MNVTSNATAAGSFPLAFGLKTSFGFMHYAKAPAINLRPKESLLPEMSDGVLALVAPVVAYWALSGIFHVIDTFHLAEKYRIHPSEEVAKRNKASRMHVFLEVILQHIIQTIVGLIFMHFEPIYMTGFEENAMWKLRADLPRIIPDAAIYYGYMYGMSALKIFAGFLFVDTWQYFLHRLMHMNKTLYKWFHSVHHELYVPYAYGALFNNPVEGFLLDTLGTGIAMTLTHLTHREQIILFTFATMKTVDDHCGYALPLDPFQWLFPNNAVYHDIHHQQFGIKTNFAQPFFTFWDNLFQTNFKGFEEYQKKQRRVTIDKYKEFLQERELEKKEKLKNFKAMNAAENEVKKEK
What is the function of this protein?
Required for hydroxylation of C-4 in the sphingoid moiety of ceramide.  Catalyzes the conversion of sphinganine to phytosphingosine in sphingolipid biosynthesis.  Involved in the response to syringomycin.
What are the official names of this protein?
Sphingolipid C4-hydroxylase SUR2, Syringomycin response protein 2.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TPS18_HETPA
Sequence: MLSLNEIKFPSHWNLVPNEPSYVDYVYREGLDLGVWRPDNQRDRMAHNNVVSLTRFFWPNVDFERLVMGGELMLWFFTFDDGLDAGIYDDQKSVDLVRRMEIVFMDGPEKVAFRLRSRCLEMCGKRRDTFNRFISSCVQWVDSIIPFNKVKDGGSPHIELYSFLRKINIGAYPCVTLTEVMLNHHLEPYIWSDPRWLKMNENIAIVVTLINDLVSYEKEVNDNAGVLNPLYFFQHQNNQNLPDSYRKMVNLIHQYVNDYLHLEEGFLRSMAPFHDALQHQEVHFMLDHLHYLITGSRMWSMQTPRYCSPTSPFIEMRPPSKSYL
What is the function of this protein?
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene protoillud-7-ene.
What are the official names of this protein?
Terpene synthase 18.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: Y1993_MYCTU
Sequence: MVTHELLVKAAGAVLTGLVGVSAYETLRKALGTAPIRRASVTVMEWGLRGTRRAEAAAESARLTVADVVAEARGRIGEEAPLPAGARVDE
What are the official names of this protein?
Uncharacterized protein Rv1993c.
Protein: FABZ_STRZT
Sequence: MIDIQGIKEALPHRYPMLLVDRVLEVSEDTIVAIKNVTINEPFFNGHFPQYPVMPGVLIMEALAQTAGVLELSKPENKGKLVFYAGMDKVKFKKQVVPGDQLVMTATFVKRRGTIAVVEAKAEVDGKLAASGILTFAIGN
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRNA_BACSU
Sequence: MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPEKNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKIDHHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRFLFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASVFIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLARKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE
What is the function of this protein?
Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities.  Degrades RNA and DNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 3-mers.  Directionality is controversial; shown to degrade 5-mers and less in a 3' to 5' direction (PubMed:17586819), and 11-mers in a 5' to 3' direction (PubMed:21087930).  Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.
What are the official names of this protein?
Bifunctional oligoribonuclease and PAP phosphatase NrnA, 3'(2'),5'-bisphosphate nucleotidase, 3'-phosphoadenosine 5'-phosphate phosphatase, PAP phosphatase, nanoRNase.
What is the protein family that this protein belongs to?
Belongs to the NrnA oligoribonuclease family.
Protein: PPR35_ARATH
Sequence: MMKWSIVKRIPVYGGSFISMKHMMLVPADLSWSCSFSGMHSLINTGEEDEEELLKKIVNHSESGSKIISKIDYTNLVEKFTRDGNLSGAYDLLQSLQEKNICLPISVFKNLLAAAGELNDMKLSCRVFREVLILPGKEPLSSDCYLNLARAFINTDDCTYLTSLLKEISESSLPYRLIVMNRIIFAFAETRQIDKVLMILKEMKEWECKPDVITYNSVLDILGRAGLVNEILGVLSTMKEDCSVSVNIITYNTVLNGMRKACRFDMCLVIYNEMVQCGIEPDLLSYTAVIDSLGRSGNVKESLRLFDEMKQRQIRPSVYVYRALIDCLKKSGDFQSALQLSDELKNTSSLDLAGPQDFKRHLRSHRR
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g11900.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: RL19_THEP1
Sequence: MDHLVKIIEKKYEKKEIPDFRPGDTVRVHVKVIEGDRERTQVFEGIVIAKRGSGINKTFTVRRIGSHGVGVERIFPVHSPVVEKIEVVRKGKVRRAKLYYLRNVRGKIRIKERRD
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: YMDB_ENTCC
Sequence: MKPQIDVIHGDITTMHVDVIVNAANPSLMGGGGVDGAIHRAAGPQLLEACKTVRQQQGECPPGHAVITLAGDLPAKAVIHAVGPIWHGGDRHEASILEEAYRNCLRLAADNGYKTMAFPAISTGVYGYPKAAAATIAVDTVYRYLSLKPMPEKVTFVCFDEETLHLYQRLLTQRGQELEI
What is the function of this protein?
Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate.  Down-regulates ribonuclease 3 (RNase III) activity.  Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
What are the official names of this protein?
O-acetyl-ADP-ribose deacetylase, Regulator of RNase III activity.
What is the protein family that this protein belongs to?
Belongs to the YmdB family.
Protein: OR2A7_HUMAN
Sequence: MGDNITSITEFLLLGFPVGPRIQMLLFGLFSLFYVFTLLGNGTILGLISLDSRLHAPMYFFLSHLAVVDIAYACNTVPRMLVNLLHPAKPISFAGRMMQTFLFSTFAVTECLLLVVMSYDLYVAICHPLRYLAIMTWRVCITLAVTSWTTGVLLSLIHLVLLLPLPFCRPQKIYHFFCEILAVLKLACADTHINENMVLAGAISGLVGPLSTIVVSYMCILCAILQIQSREVQRKAFCTCFSHLCVIGLFYGTAIIMYVGPRYGNPKEQKKYLLLFHSLFNPMLNPLICSLRNSEVKNTLKRVLGVERAL
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2A7, Olfactory receptor OR7-18.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KDPC_HALSA
Sequence: MNRQDLAVPLRLLGVSLLVFGLLYQGSLMAIGDAVFPNSSAGSPVYVDGQEQPVGSQMIGQQFRPGQPEDVQYFWSRPSANDYNAMTSASTNWGPTNPLLSERVRADLQNISQYETPDDSVPVNLVSESGSSYDAHISPAAAEYQVLRVANQTGISEQRLNEMIDEATKEPWLGIWGHERVNVLELNLMVRDALNEQNETDQNSDMNASEIANGDH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MNMA_ECOL5
Sequence: MSETAKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWDNVFELFLAEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRADVDGKSRLLRGLDSNKDQSYFLYTLSHEQIAQSLFPVGELEKPQVRKIAEDLGLVTAKKKDSTGICFIGERKFREFLGRYLPAQPGKIITVDGDEIGEHQGLMYHTLGQRKGLGIGGTKDGTEEPWYVVDKDVENNILIVAQGHEHPRLMSVGLIAQQLHWVDREPFTGTMRCTVKTRYRQTDIPCTVKALDADRIEVIFDEPVAAVTPGQSAVFYNGEVCLGGGIIEQRLPLPV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECF_PETMO
Sequence: MPNIDFVGKRSFFIYLSIALILFSVIVIFVKGFNLGVDFSGGSEIIVSFDKSYTIDELRNGLQTINQEYATAKIIQTNPGGGASDQFFYIITVRDSFPTLEEKQMFINSLEESFSDSSLNIEQFNDVSGYAAREIRSYAWYAVIISLIVLLAYITIRFQFSYGVGAILALAHDVIITLGFYSLFGIEMNLTAIAAFLTLAGYSLNDTIVVYDRIRENRSKNRGMDIESITNKSINEVIVRSLNTSLTTFLVVFMMFLLGGRSIASFAFGLTVGVIIGTYSSLYIASPIVIGMVKRRKKTQKA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecF.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTRA2_METRM
Sequence: MADKKPTAENWPVVSGDYIVGDPESPVAVTTLASHNEDIPAAAGAAIAGPCKTENLGIEKVVANIISNPNIRFLILCGAEVQGHITGQSFKALYENGCDPEKKKITGATGAIPFVENIPMEGVERFQQQLELVDMIDNEDGGAITAKVKECIEKDPGAFEEDSLVIKIDEERYSKKSSFVESSSESEKIESEA
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit A 2, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A 2.
What is the protein family that this protein belongs to?
Belongs to the MtrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL16_STAAW
Sequence: MLLPKRVKYRRQHRPKTTGRSKGGNYVTFGEFGLQATTTSWITSRQIESARIAMTRYMKRGGKVWIKIFPHTPYTKKPLEVRMGAGKGAVEGWIAVVKPGRILFEVAGVSEEVAREALRLASHKLPVKTKFVKREELGGETNES
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: KPK1_PHAVU
Sequence: MESSVNGVDSLSEVQNSVSGVHHHDPLPSGTPQPSRPPLRASRNYDGGHQTKAIHHHNSHVINQKHSHQEGKTLKQEGLPTKLSSKQPPLDDSKGCEPNGVLESEKKRVVDNHGKNYSQPDATFCASPQNSFYSATVYSEAKESFTNTEVSECASVDKSCESEVANSSDFNESRKTSICRASTGSDASDESSTSSLSSVLYKPHKANDIRWEAIQAVRTRDGMLEMRHFRLLKKLGCGDIGSVYLAELSGTRTSFAMKVMNKTELANRKKLLRAQTEREILQSLDHPFLPTLYTHFETEIFSCLVMEFCPGGDLHALRQRQPGKYFSEHAVRFYVAEVLLSLEYLHMLGIIYRDLKPENVLVREDGHIMLSDFDLSLRCSVSPTLVKSSNNLQTKSSGYCVQPSCIEPTCVMQPDCIKPSCFTPRFLSGKSKKDKKSKPKNDMHNQVTPLPELIAEPTNARSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGRTPFKGSANRATLFNVIGQPLRFPESPTVSFAARDLIRGLLVKEPQHRLAYRRGATEIKQHPFFQNVNWALIRCATPPEVPRQVINLPQTEKDLGVKPSGNYLDIDFF
What are the official names of this protein?
Protein kinase PVPK-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: YCCM_ECOLI
Sequence: MAENKRTRWQRRPGTTGGKLPWNDWRNATTWRKATQLLLLAMNIYIAITFWYWVRYYETASSTTFVARPGGIEGWLPIAGLMNLKYSLVTGQLPSVHAAAMLLLVAFIVISLLLKKAFCSWLCPVGTLSELIGDLGNKLFGRQCVLPRWLDIPLRGVKYLLLSFFIYIALLMPAQAIHYFMLSPYSVVMDVKMLDFFRHMGTATLISVTVLLIASLFIRHAWCRYLCPYGALMGVVSLLSPFKIRRNAESCIDCGKCAKNCPSRIPVDKLIQVRTVECTGCMTCVESCPVASTLTFSLQKPAANKKAFALSGWLMTLLVLGIMFAVIGYAMYAGVWQSPVPEELYRRLIPQAPMIGH
What are the official names of this protein?
Putative electron transport protein YccM.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AMPKA_DICDI
Sequence: MSSYQQNPIGSFGGLYGSGGIEKSSQIIGNYRLDKTLGIGSFGKVKLAEHIRTGVKVAIKILNRTKIKNLKMDEKIRREIQNMKLFRHPHIIKLYEVIETTTDIFMVMEYVTGGELFEYIVKNGKLLEDESRRLFQQMISGVDYCHHHMVVHRDLKPENLLLDPINKCIKIADFGLSNMMQDGDFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYAFLCAKLPFDDESIPMLFKKIREGVFSIPDFVSPSCADLIKKMLVVDPVKRITIHEIRNHPWFQVKLPKYLSSPHTFLSKSIQTINNSILNEMVQVYAPIDRERIIEELQKSGEVNDLIVSYHLLVDSKRGSYENEINSPNLVSPITTPIMSSAQKSPIMFTTTTGFNPSNSNSISNNNNNNNNNNNNTTNNNNNTTNNNNSIINNNNINNNNINNNNNNNNNNINNNNIINNNNNNNNNNNNNNNNNNNNNNNNNNNSSISGGTEVFSISPNLNNSYNSNSSGNSNGSNSNNNSNNNTNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNCIDSVNNSLNNENDVNNSNINNNNNNNSDDGSNNNSYEGGGDVLLLSDLNGNNQLGGNDNGNVVNLNNNFQLLNSLDLNSDIQTQPHRKWYLGAISQLPPHEIMGEIYRALKKVGFEWKLTGPYQLRCRMVNGKPIKLVLQLFRVAENRYLLDIKKIEGEIFIFFDICSLMLEELNL
What is the function of this protein?
Activated enzyme phosphorylates target proteins and initiates downstream signaling pathways that shift metabolism from anabolic to catabolic pathways.  Acts as a highly sensitive cellular energy sensor.
What are the official names of this protein?
5'-AMP-activated serine/threonine-protein kinase catalytic subunit alpha, AMPKA, Protein kinase, AMP-activated, alpha subunit, SNF1/AMP-activated kinase catalytic subunit, Sucrose non-fermenting protein snfA.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Protein: RS11_PROMT
Sequence: MATTSKKSGSKKSKRNVPNGVVHIQSTFNNTIVSITDTSGEVISWSSAGASGFKGARKGTPFAAQTAAELAARRALEQGMRQIEVLVRGPGSGRETAIRALQVAGLEITLIRDVTPLPHNGCRRPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.