PharMolix/UniProtQA huggingface dataset:
Protein: ANMK_SALPC
Sequence: MKSGRFIGVMSGTSLDGVDVVLAAIDETMVAQQASLTWPIPVHLKKGILDICQGQPLTLSQLGQLDTQLGRLFAQAVNALLAQQRLQPRDIVAIGCHGQTVWHEPTGEAPHTLQIGDNNHIVAHTGITVVGDFRRRDIALGGQGAPLVPAFHHALLGHPTEKRMVLNIGGIANLSLLFPGQAVRGYDTGPGNMLMDAWIWRQCAQPYDKDAAWAKEGQVILPLLQKMLRDPYFAASAPKSTGREYFNYGWLERHLTAFPGADARDVQATLAELTAVSIAQQVLLNGGCERLMVCGGGSRNPLVMARLAALLPGIEVSTTDKAGISGDDMEALAFAWLAWRTLAGLPGNLPSVTGATEASVLGAIYPANPITQS
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: PROB_GEOMG
Sequence: MRTAILKKVKRIVIKIGSRVLTGDENGLNHAFIARLAAETASLRQQGRQVIVVSSGAVAAGRRELGIEGRPKSIPQKQAAAAIGQSRLMRAYEEDFGRFGHKVAQILLTRDDLANRRRFLNARATLDTLLDFGVIPVINENDTVVVDEIKFGDNDNLSALVTNLAEAHLLVILTDIDGFYDSDPRANPDARLIHLVKSITRETERAAGDSGSSVGTGGMVTKLAAAKKAGQFGVPTLMLNGTVPGILTKAFAGREVGTLFLPARESLNRRKHWIAHTLRPSGRVIVDDGARTVLSRQGKSLLPSGVIRVEGEFDRGACVRVCGADGAEIARGVVDYSHAEIERILGHRSGEIEAILGYKYGDEIIHRDNLVVL
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTSM_SERMA
Sequence: MKKHSNNLDLFDQTEECLESNLRSCKIIVGDAREAVQGLDSEIFDCVVTSPPYWGLRDYGNGGQIGAEDNINDYIKDLVDLFRDVRRTLKDDGTLWLNIGDSYTSGGRTWRDKDDKNKGRAMSYRPPTPEGLKPKDLIGVPWRLAFALQNDGWYLRTDIIWNKPNCQPESVRDRPTRSHEYIFLLSKGKKYYYDWESIKEPASDPKMDKKNRRTVWNINTEPYPGSHFAVFPRAMARLCVLAGSRPGGKVLDPFFGSGTTGVVCQELDRECVGIELNEEYASLAKERILRRR
What is the function of this protein?
A beta subtype methylase thatnrecognizes the double-stranded sequence 5'-CCCGGG-3', methylates C-2 on both strands, and protects the DNA from cleavage by the SmaI endonuclease.
What are the official names of this protein?
Type II methyltransferase M.SmaI, M.SmaI, Modification methylase SmaI, N-4 cytosine-specific methyltransferase SmaI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.
Protein: APT_PSE14
Sequence: MTFDQSNFKSLIRPVIDFPKPGVVFRDITPLFQSPKATRQVIDSFVQRYIEADFSHIGVMDARGFLIGSVVAYQLNKPLVLFRKQGKLPADVLSEAYQTEYGEAYLEVHADSLCEGDSVIMFDDLIATGGTLIAAANLIRRMGAEVHEAVAIIDLPELGGSKRLNDLKIPTFCLTEFALDEQ
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AOC_ORYSI
Sequence: MAAAAPSRVSVRAAAPGQTGGFAKIRPQVVVAAAARSAGVSGRRARSVRASLFSPKPATPKDARPAKVQEMFVYEINERDRESPAYLRLSAKQTENALGDLVPFTNKLYSGSLDKRLGISAGICILIQHVPERNGDRYEAIYSFYFGDYGHISVQGPYLTYEESYLAVTGGSGVFEGAYGQVKLNQIVFPFKIFYTFYLKGIPDLPRELLCTPVPPSPTVEPTPAAKATEPHACLNNFTN
What is the function of this protein?
Confers resistance to incompatible strains of the blast fungus Magnaporthe grisea, jasmonic acid (JA) thus playing a significant role in the resistance to fungal infection.  Implicated in riboflavin-induced resistance to the sheath blight Rhizoctonia solani.  Required for Pseudomonas fluorescens-mediated JA-dependent induced systemic resistance (ISR).  Confers some resistance, independently of the JA pathway but probably via OPDA accumulation, to brown planthopper (BPH, Nilaparvata lugens), a destructive, monophagous, piercing-sucking insect, mainly by reducing its feeding activity and survival rate.  Triggers resistance to the chewing insect striped stem borer (SSB) Chilo suppressalis, to the root hemiparasite witchweed Striga hermonthica, and to the root feeder insect rice water weevil Lissorhoptrus oryzophilus, in a JA-dependent manner, by attenuating both the growth mass and growth rate of caterpillars.
What are the official names of this protein?
Allene oxide cyclase, chloroplastic, OsAOC.
What is the protein family that this protein belongs to?
Belongs to the allene oxide cyclase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SSRP_CALS8
Sequence: MAEKNKQDDIKVIATNRKAYHDYFIEETIEAGIELKGTEVKSVRLGHVNLKDSFARVENGEVFLYNMHISPYEKGNIFNVDPMRDRKLLLHKSEINRLAGYVQQKGYTLIPLKIYLKRGKIKVELAVAKGKKLFDKREAIAKRDAELEIRKKMKEYLR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SYK_LEPIC
Sequence: MSESNELIEQRIQKIEELKKQGINPYPVRFFPDSKSKDIAEKFEKNPTGPETKFKLGGRLHSKRVMGKASFAHLKDNSGIIQLYATKDDLGETQYSIFKSLDLGDIIGLEGYLFKTQKGEITLHVTSVELLSKCIRPLPVVKEKDGVVYDAFADVEQRYRMRYVDLIVNDHVRDTFITRSKIVSEIRSFLTQEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLIVGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYMAFGDMSTMLDLTERLITHLAQKICGTLKIQYGKDLIDLSPPWKRTTYVDIIKEYSGIDFSQIISLEEAKKKASELKVDVSKCQTIWKVADEVFSEKAEPNLIQPIFITDYPKELSPLAKSNPDKPGYVERFEPYVAGREIGNAFTELNDPFDQKERFEDQVKQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTNSHSIRDTILFPLMRPE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_THEPX
Sequence: MELKGKKVLVAGLGVSGIALCKVLDSLKAKVIAYDEKEYDVLKENLEEIKSLSIDFRFGKFKKEFLEGVDLIVLSPGVPIDSDIVKTAQEKKIELLGEVEFAYRFSKAPIYAITGTNGKTTTTSLLGEMFKNTGRKVYVAGNIGYPLIYAVMEAAEDDFIVAEISSFQLETIKEFKPKISCIINITPDHLDRHKTFENYRDIKGRIFENQREDEYTVLNYDDPVTWSLKNKAKCRVFPFSRKSLLENGAYIKDGSIYISVNGNAEKIIDIEEIYIPGEHNLENALAASSVAYLSGISADVIANTLKTFKGVEHRIEFVDEINGVKFYNDSKGTNPDASIKAIQALKTPIVLIAGGYDKGSEFDEFVKAFNGKVKKLILIGQTAKKIRDTARKYSYPEDDILFAGTLEEAVKKAYESAKEGDSVLLSPACASWDMFRNFEERGRIFKKAVAELRR
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_SYNPW
Sequence: MPKVLALETSCDESAAAVVQHSAGGLEVLAHRIASQVEEHAQWGGVVPEIASRRHVEALPHLISAVLDEAGLAVGEMDAVAATVTPGLVGALMVGSLTGRTLAALHHKPFLGVHHLEAHLASVRLASSPPEAPYVVLLVSGGHTELILVDSDSGLQRLGRSHDDAAGEAFDKVARLLGLAYPGGPAIQAAAKAGDPKRFSLPKGRVSRPEGGFYPYDFSFSGLKTAMLRQVESLKAQSDALPLEDLAASFEQIVVDVLVERSLRCCLDRGLSTLVMVGGVAANVRLRVQMEQQGRERGVSVHLAPLAYCTDNAAMVGAAALGRLQAGWGSSSIRLGVSARWPLEAGGDLYAQDPQF
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIS1_FELCA
Sequence: MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
What is the function of this protein?
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation.  Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity).  Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome.  Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate.  Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates.  During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules.  Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors.  May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.  Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos.  May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).
What are the official names of this protein?
Platelet-activating factor acetylhydrolase IB subunit beta, Lissencephaly-1 protein, LIS-1, PAF acetylhydrolase 45 kDa subunit, PAF-AH 45 kDa subunit, PAF-AH alpha, PAFAH alpha.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus membrane. Note=Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes.
Protein: XSC_RHIME
Sequence: MKMTTEEAFVKVLQMHGIEHAFGIIGSAMMPVSDLFPKAGIRFWDCAHETNAGMMADGFSRATGTMSMAIGQNGPGVTGFITAMKTAYWNHTPLLMVTPQAANKTIGQGGFQEVDQMAMFEEMVCYQEEVRDPSRIPEVLNRVIEKAWRGCAPAQINIPRDFWTQVIDVDLPRIVRFERPAGGPAAIAQAARLLSEAKFPVILNGAGVVIGNAIQESMALAEKLDAPVCCGYQHNDAFPGSHRLSVGPLGYNGSKAAMELISKADVVLALGTRLNPFSTLPGYGIDYWPKDAAIIQVDINADRIGLTKKVTVGICGDAKQVAQQILQQLAPAAGDASREERKALVHQTRSAWLQQLSSMDHEDDDPGTEWNVGARQREPDRMSPRQVWRAIQAVLPKEAIISTDIGNNCAIGNAYPSFEQGRKYLAPGMFGPCGYGFPSIVGAKIGCPDVPVVGFAGDGAFGISMNEMTSIGREGWPAITMVIFRNYQWGAEKRNTTLWYDNNFVGTELNPNLSYAKVADGCGLKGVTVDTPAALTEALAKAIEDQAKGITTFVEVVLNQELGEPFRRDAMKKPVAVAGIDRADMRTQRRM
What are the official names of this protein?
Probable sulfoacetaldehyde acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 2AAA_MOUSE
Sequence: MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
What is the function of this protein?
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:10100624, PubMed:26974206).  Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity).  Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity).  Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (PubMed:26974206, PubMed:33505023).  Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (PubMed:33505023).
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, centromere. Lateral cell membrane. Cell projection, dendrite. Note=Centromeric localization requires the presence of BUB1.
Protein: SUFA_BACSU
Sequence: MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYGMGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASCGCGSSFRTATNAGKPEEC
What are the official names of this protein?
Uncharacterized protein SufA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: PDXH_SHEDO
Sequence: MSDLSDIRREYTKGGLRRKDLPDNPMALFETWMTQAKEANLSDPTAMCVATVDENGQPFQRIVLLKRFDDTGFVFFTNLESRKAKQIAINKQISLLFPWHPLERQVAVLGEAEPLSMMEVAKYFISRPKDSQIAAWVSKQSSKITARQALEGKFNEMKAKFAQGEVPIPKFWGGFLVRPKSIEFWQGGEHRLHDRFIYTKAASEWQIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: SPIKE_CVCBG
Sequence: MIVLTLCLFLVLYNSVICTSNNECVQVNVTQLPGNENIIRDFLFQNFKEEGTVVVGGYYPTEVWYNCSRTARTQAFKTFSNIHAFYFDMEAMENSTGDARGKPLLVHVHGNPVSIIVYISAYRHDVQGRPKLKHGLLCITKNSTTDYDRFTANQWRDICLGEDRKIPFSVVPTDNGTKLFGLEWNDDYVTAYISDDSHYLNINNNWFNNVTLLYSRSSTATWQHSAAYVYQGVSNFTYYKLNNTNGLKSYELCEDYEYCTGYATNVFAPTPGGYIPEGFSFNNWFMLTNSSTFVSGRFVTNQPLLVNCLWPVPSFGVAAQEFCFEGAQFSQCNGVSLNNTVDVIRFNLNFTTDVQSGMGATVFSLNTTGGVILDISCYNDTVSESSFYSYGEIPFGVIDGPRYCYVLYNGTALKYLGTLPPSVKEIAISKWGHFYINGYNFFSTFPIDCISFNLTTGASGAFWTIAYTSYTEALVQVENTAIKKVTYCNSHVNSIKCSQLTANLQNGFYPVASSEVGLVNKSVVLLPSFYSHTSVNITIDLGMRRSGYGQPVASSLSNISLPMQDNNTDVYCIRSNQFSFYVHSNCKSASWDNIFNSACTDVLEATAVIKTGTCPFSFDKLNNYLTFNKFCLSLNPTGANCKFDVVARTRTNEQGVGSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRNGVGIIRKTNSTLLSGLYYTSLSGDLLGFKNVSDGVVYSVTPCEVSAQAAVIDGAIVGAMTSINSELLGLTHWTTTPNFYYYSIYNYTNERVRGTVTDSNDVDCEPIITYSNIGVCKNGALVFINVTHSDGDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSRYVCNGNSRCNKLLTQYVSACHTIEQALAMGARLENMEIDSMLFVSENALKLASVEAFNSTDNLDPIYREWPNIGGSWLGGLKDILPSHNSKRKYRSAIEDLLFDKVVTSGLGTVDEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANDDKMAMYTASLAGGITLGALGGGAVSIPFAVAVQARLNYVALQTDVLNKNQQILANAFNQAIGNITQAFGNVNDAIHQTSKGLATVAKALAKVQDVVNTQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLTALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCGNGTHLFSLANAAPNGMIFFHTVLLPTAYETVTAWSGICASDGNRTFGLVVKDVQLTLFRNLDYKFYLTPRTMYQPRVATSSDFVQIEGCDVLFVNATVIELPSIIPDYIDINQTVQDILENFRPNWTVPELPLDIFNATYLNLTGEINDLEFRSEKLHNTTLELATLIDNINNTLVNLEWLNRIETYVKWPWYVWLLIGLVVIFCIPLLLFCCCSTGCCGCFGCIGSCCHSMCSRRQFESYEPIEKVHVH
What is the function of this protein?
S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection.  Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion.  S2 region belongs to the class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the alphacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly.
Protein: TRMN6_ECOBW
Sequence: MSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTDDSVMIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQQTVRFDLIISNPPYYQQGVECSTPQREQARYTTTLDHPSLLTCAAECITEEGFFCVVLPEQIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYSEAYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_LISW6
Sequence: MSKEVLTKSKEKMDKAEQALTRQLGTIRAGRANASLLDRLSVDYYGAPTPVNQMASISVPEARMLLITPYDKTVLGEIEKAILKSDLGLTPNNDGSVLRLSIPQLTEERRKELVKEVKKEAEEAKVAVRNIRREANEELKKLEKNGDITEDDLRSYGEDVQKLTDESIKNIDNITKDKEAEILEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPA_SHEPC
Sequence: MINGSIVALITPMNSDGSIDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMSEHVTVVAQTVKFAAGRIPVIGGNGANATAEAIELTKSLSKVGVAGMLGVTPYYNKPTPKGLIAHYKAVAASTDIPQILYNVPGRTAVDMQPETVAELVGVSNIIGVKEATGDIARVKRLRELCGNDFKLYSGDDATAREFLLLGGNGVISVANNIVPKAFKAMCDAALAGNAELALSLDTPLRGLYSTLFCEANPIPVKWAAHRMGLIKCGHIRLPLTELSEQCHGLLIDAMTRAQIEVK
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP7_ROTPC
Sequence: MVCTTLYTVCVILCILFIYMLLFRKMFHLIADALVITLIISNCIGWSQGQMFIDDIHYNGNVETIVNATDPFDVRSLCIYFPNAVVGSQGPGKTDGYLNDGNYAQTIAALFETKGFPRGSIVLKTYTKVSDFVDSVEMTCSYNIVIIPDSPTNSESIERIAEWILNVWRCDDMNLDIYTYEQTGIDNLWAAFGSDCDVSVCPLDTTMNGIGCSPASTETYEVLSNDTQLALLNVVDNVKHRIQMNTASCKLKNCIKGEARLNTALIRISTSSSFDNSLSPLNDGQTTRSFKINAKKWWTIFYTIIDYINTIIQTMTPRHRAIYPEGWMLRYA
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER. cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: TTCA_PSE14
Sequence: MGTLSVNQNKLQKRLRRLAGEAVADFNMIEEGDKVMVCLSGGKDSYTMLDVLMHLQKVAPIKFDIVAVNMDQKQPGFPEHVLPAYLKELGIEYHIVEKDTYSVVKELIPEGKTTCSLCSRLRRGTLYTFADEIGATKMALGHHRDDIVETFFLNMFFNGSLKAMPPKLRADDGRNVVIRPLAYCHEKDIQAYSDLKQFPIIPCNLCGSQENLQRQVVKDMLIDWERKTPGRTESIFRALQNVQPSQLADRNLFDFSNLRIDETAASRFVNVVNI
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.