PharMolix/UniProtQA huggingface dataset:
Protein: RBL_PEA
Sequence: MSPQTETKAKVGFKAGVKDYKLTYYTPDYQTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYEIEPVPGEDNQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPYAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMLKRAVFARELGVPIVMHDYLTGGFTANTTLSHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDYIKKDRSRGIYFTQDWVSLPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNAIIREACKWSPELAAACEVWKEIKFEFPAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (Probable).  Binds to abscisic acid (ABA); only half of the possible binding sites are occupied in the crystal and there are indications this is a low affinity site (PubMed:26197050).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RPOC_ALIF1
Sequence: MKDLLKFLKAQHKTEEFDAIKIGLASPDQIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRDRMGHIELASPVAHIWFLKSLPSRIGLLMDIPLRDIERVLYFESYVVTEPGMTDLERSQLLSEEEYLDKLEEFGDEFTAKMGAEAIKDLLASMDMQAEIEDMREELETTNSETKRKKVTKRLKLVEAFVQSGNNPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYSKLEGRGLATTIKAAKKMVEREEAIVWDILDDVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARTLMMSTNNILSPASGDPIIVPSQDVVLGLYYMTREKINAKGEGMYLEGFAEAEKAYRTGVAELHARVKVRITEVLRDENGIETRETKLVDTTVGRAMLWQIVPEGLPYSIINQKLGKKQISNLLNEAYRTLGLKDTVVFADQIMYTGFAYAALSGASVGIDDMVIPDAKYTKVADAEEEVKQIQEQYQSGLVTAGERYNKVIDIWAATNEQVAKEMMDNLSSETVLNRDGEEEQQESFNSVYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVNQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDVVVHLDDCGTYEGVTMTPLIEGGDVKEPLHERVLGRVVAEDVLKPGTDEILLPRNTLLDEKQCQIVEENSVDQIKVRSVVSCEADFGCCANCYGRDLARGHMVNQGESVGVIAAQSIGEPGTQLTMRTFHIGGAASTAAADNSIQVKTTGSIKLHNAKHVTNGEGNLVITSRASELTVIDEHGRTKESYKLSYGTILTKKDGDAVNQGDKIASWDPHTMPIITEVQGQVQFVDMIDGVTITTQTDELTGLSSIVVLDAAERASAGKDMRPTVKLVDANGNDIMIPGTEMPAQYFLPGKAIVNLADGGNVGIGETLARIPQASSGTKDITGGLPRVADLFEARKPKEPAILAEHAGIVAFGKETKGKVRLLITRDDNGEVYEEMIHKHRQLNIFEGDKVERGDVISDGPETPHDILRLRGIHAVTEYITNEVQEVYRLQGVKINDKHIETIVRQMLRKCTITHSGDSTFLEGEQLEFANVTIANRQLEAEGKQPARFERDLLGITKASLATESFISAASFQETTRVLTEAAVSGKRDELRGLKENVIVGRLIPAGTGFAYHQERQKQKAVEQEGPSAEQATDNLAALLNAGFSSEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: NQRD_YERPG
Sequence: MADSKEIKRVLLSPLFDNNPIALQILGVCSALAVTTKLETALVMTLAVTLVTAFSSFFISLIRNHIPNSVRIIVQMVIIASLVIVVDQVLRAYAYEISKQLSVFVGLIITNCIVMGRAEAYAMKSPPIESFMDGIGNGLGYGVILVLVGFVRELVGSGKLFGVTVLETVQNGGWYLPNGLFLLAPSAFFIIGLLIWGLRTLKPAQIEKE
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPB_ARTGP
Sequence: MTVGRRLNDEEAIPLTAKEAGSRDSIDSSSTASVSLTLVDGTNHTTAKPSKSAHKGVSRDRYADEKYRDDVEEDWEEDRYIPSNAKPSQRRTQIVFWLLVALCVGGWAVAFLFFVTSPGNTISTTPDTGSGSPDSDVIKPGSPPAGKKIPLDDVLGGAWSPTQHTISWIAGPKGEDGLLLQKSEGGTGPYLHVEDVRNIHGTQSNNKSMVLMKDSVFFVNDERISPEKVWPSPDLKTVLAMTRQKKNWRHSYTGLYWLFDVETQTAQPLDPGAPNGRIQLATWSPTSDAVAFTRDNNLYIRNLTSKTVKAITTDGGANLFYGIPDWVYEEEVFEGNSATWWSLDGKYISFLRTNETTVPEFPVDFYLSSPPDYAPKPGEEAYPYVQQIKYPKAGAPNPTVGLQFYDVEREESFSVDVKDSLNDDDRIIIEVIPGSNGRILVRETNRESYIVKVAAIDATKREGKIIRSDNIDEIDGGWVEPSHTTTYIPSDPASGRPNDGYIDTVIHEGYNHLAYFTPLENPKPKMLTTGKWEVVAAPSGVDLKNNVIYFVATKESPIDRHVYSVKLDGSELQLLKDSEKSAYYDVSFSHGAGYMLLQYQGPKIPWQKLMNSPSNTDSYTEILEENKRLAKLSNEFALPSLHYSSITVDGFKLPVVERRPPNFDETKKYPVLFHLYGGPGSQTVNKKFLVNFQTYVASTLGYIVVTVDGRGTGFNGRKFRCIVRRNLGHYEAYDQIQTAKAWGRKPYVDKTRIAIWGWSYGGFMTLKTLEQDAGETFQYGMAVAPVTDWRYYDSIYTERYMHMPQNNEEGYETASVSNSTALSQNTRFLIMHGSADDNVHFQNTLTLLDKLDIMGVHNYDMHVFPDSNHGIYFHHAYKMVHQRLSDWLVNAFNGEWVRLRDPKPTIIKRVIRRLLHR
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: LSPA_RHOJR
Sequence: MDDERVSQDPTAENETDAEDRNDDDPSGSAPPQPVTHQRRLLLFVIAGVVLATDLLTKILAVANIEPGRPVWLIGDIVSLRLVRNPGAAFSMATGMTWLLTLVAVGVVIGVVRIGRTLRSPWWALGLGLVLGGALGNLVDRFFRAPGVMQGHVVDFVSVGWWPVFNVADSGIVCGAILLVVLTLIGLEPDGTRKGVEK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IMB1_SCHPO
Sequence: MNAGEFLAQTLSPDANVRLNAEKQLENAARTDFAQYMVLLAQELANDNSMPYIRMAAGLALKNAITAREEARKLEYQQLWQSLPVEIKQQVKSLALQTLGSSEHQAGQSAAQLVAAIAAYELATNQWPDLMVTLVANVGEGQPSALKQHSLQTIGYICESVSPEVLSAQSNAILTAVVAGARKEEPDAAVRLAALGALYDSLEFVRENFNNEYERNYIMQVVCEATQSPEASIQTAAFGCLVKIMHLYYDTMPFYMEKALFALTTQGMYNTNEQVALQAVEFWSTVCEEEIEVNLEIQEAQDLNEVPARQNHGFARAAAADILPVLLKLLCNQDEDADEDDWNISMAAATCLQLFAQVVGDLIVNPVLAFVEQNIQNPDWHQREAAVMAFGSVLEGPNVAMLTPLVNQALPVLINMMVDPVIFVKDTTAWALGQISSFVADAINPEIHLSPMVSALLQGLTDNPRIVANCCWAFMNLVCHFAPVDNHQTSVMTPFYEAIIGSLLHVTDQKGNENNSRTSGYETLGTLITFSSDSVLPMIANVLSIILTRLETSIQMQSQILDVEDRANHDELQSNLCNVLTSIIRRFGPDIRTSSDQIMNLLLQTMQTAPKQSVVHEDVLLAIGAMMNSLEEQFEVYVPSFVPFLSSALSNEQEYQLCSVAVGLVGDLARALNAKILPYCDDFMTRLVQDLQSSVLDRNVKPAILSCFSDIALAIGAAFQTYLEAVMVLLQQASSVQAPPGANFSMIDYVDALRLGIVEAYVGITQAVRTDNRLDLIQPYVHSMFTLLNMITADPECSESLTRAALGLLGDLAESFPKGELKSYFAADWVAALLNSGKTKISSQQTKDLARWATEQVKRQARA
What is the function of this protein?
Importin beta subunit that functions in nuclear protein import through association with the importin alpha subunit, which binds to the clasical nuclear localization signal (cNLS) in cargo substrates.  Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by importin beta through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, GTP-Ran binds to importin beta and the three components separate, leading to release of the cargo.  Importin alpha and beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin beta.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
What are the official names of this protein?
Importin subunit beta-1, Importin-95, Karyopherin subunit beta-1, Karyopherin-95.
What is the protein family that this protein belongs to?
Belongs to the importin beta family. Importin beta-1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope. Nucleus, nuclear pore complex.
Protein: COXX_PSECP
Sequence: MTATVSTTDTPLNASRASGPGFARKAKAYLALTKPRVIELLLVSTLPTMIYAERGFPSIGLILATLVGGAFAAGSAGAFNCYIDRDIDKLMARTENRPLVTGEVTPREALVFSWLLGAAAIAILWFGANPLSAWLGLGAIFFYVVIYTIILKRRTAQNIVWGGAAGCFPVLIAWAAVTNSVEWPAIILFMVIFLWTPPHYWPLSMRYGEDYRNAKVPMLGAIAGAKVVSVQVVLYAWAMVACSLLMVPAGGAGWVYTVTAVLAGAWFLYESHALYNRAQREDIPDKRAMKVFHGSISYLTLLFIALAVDPFVGPAVIGG
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SPO11_DROME
Sequence: MDEFSENIERIALELLSNLVHGNATLSVPRNSSGNVISEYRRVSYNNRGSRHSFCVLIYMLSRVHRLQVRGGSFTVRGLYYDNPLLVRSQSRIAEARLDVCRMLRTSPLSLGILAASKGLVAGDLRLLMTNGDVLDSSLYGGPLTLPTDPEKIDRIETLAEFVLIVEKESVFESLLSRNVFGTFERRFILITGKGYPDCCTRRIVHRLTEENQLAAYILVDADPFGVEIMLVYRHGSKSMSFSSQGLTTPALRWIGLHPSEIPALGTGAVALVAGDNKKINDLLARHDLEPGVRQELRMLQDVQLKAEIESVIDFLTDDYIPNKINRNLFL
What is the function of this protein?
Required for meiotic recombination (PubMed:9744869).  Together with mei-P22, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity).
What are the official names of this protein?
Meiotic recombination protein W68, SPO11 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the TOP6A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPD_PARP8
Sequence: MITPQEALQRTIEHREIFHDEMLHLMRLIMRGDMSPVMAAAIITGLRVKKETIGEITAAATVMREFARHVDVQDNSNFVDIVGTGGDGSHTFNISTATMFVSAAAGAKVAKHGNRGVSSKSGSADVLEALGVNIDLQPEQVAASITETGMGFMFAPNHHPAMKNIAPVRRELGVRTIFNILGPLTNPAGAPNQLQGVFHPDLVGIQVRVMQRLGARHVLVVYGRDGMDEVSLGAATLVGELRNGEITEYEIHPEDFGMQMVSNRTLKVADAAESKVLLLEALDNKPGVAREIVTLNAGTALYSANVAESIADGIRLAREAIASGKARAKVDELVRFTQQFKH
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: CYB_RHIAL
Sequence: MTNIRKTHPLVKIINNSLVDLPAPSSLSAWWNFGSLLGVCLAVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWLIRYLHANGASMFFICLYLHVGRGMYYGSYTYSETWNVGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVTALVMVHLLFLHETGSNNPTGIPSDSDMIPFHPYYTIKDMLGFLIMLAALSTLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAIIPLLHTSKQRSMMFRPLSQCLFWLLVAVLFTLTWIGGQPVEYPFIIIGQTASVLYFLIILVFMPLTSLIENHLMKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LEU1_SHISS
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSSAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: R1A_GLRV3
Sequence: MDYIRPLRVFSFPHVNNTLEYVRYNKANGDVGAFLTTMKFIGNVKLSDFTPRCAAMIYIGKLTKGVKRTFVPPPVKGFARQYAVVSGSVSALRGDGKKVLMEARTSTSATSDVSDFDVVFEAVSNALLVVHYHRVVPYAPVKREQPKPAVKQDEQKPKRQASHWAVKPTAVGVHVPLPKKQEALEPAQSVPQQSLEEKAALTFGLFFSKGGGDESDAVILRKGKLFNRALNVPIDVKNTFVWAKIWDEASRRRGYFYVKDRAVKFFPIVRGRATIEDFIVNTAPGCDVALPRIELWSMRERAFVCTTKGWCWFNNERLRGEIYRRRCFSSSFSIGFLMHLGFRSLKVIRFAGTNILHMPSLNEERTFGWKGGDVYLPNVPKTAIVAGDRTRLGGEILASVANALNQEEVYSSVVSSITNRLVLRDQSALLSHLDTKLCDMFSQRDAMIREKPSHRCDVFLKPREREKLRELFPELSIQFSDSVRSSHPFANAMRSCFNGIFSRRCGNVCFFDIGGSFTYHVKAGHVNCHVCNPVLDVKDVKRRINEILFLSTAGGDSYVSSDLLTEAASKSVSYCSRESQNCDSRADAGFMVDVYDISPQQVAEAMDKKGALVFDIALMFPVELLYGNGEVYLEELDTLVKREGDYLAYNVGQCGEMYEHSFSNVSGFFTFSYVRTSSGNVFKLEYEGYRCGYHHLTMCRAQKSPGTEVTYRSLVPSFVGKSLVFIPVVAGSSVSFKTIVLDSDFVDRIYSYALNTIGTFENRTFEYAVGAVRSQKTHVITGSRVVHSKVDISPDDMWGLVVAVMAQAIKDRAKSIRSYNFIKASEGSLAGVFKLFFQTVGDCFSNAVSVYAKAMVHDNFNVLETLMSMPRAFIRKVPGSVVVTICTSGASDRLELRGAFDISKETFGRKLKNSRLRVFSRAIVEDSIKVMKAMKTEDGKPLPITEDSVYAFIMGNVSNVHCTRAGLLGGSKATVVSSVSKGLVARGAATKAFSGITSFFSTGSLFYDRGLTEDERLDALVRTENAINSPVGILETSRVAVSKVVAGTKEFWSEVSLNDFTTFVLRNKVLIGIFVASLGAAPIAWKYRRGIAANARRYAGSSYETLSSLSSQAAGGLRGLTSSTVSGGSLVVRRGFSSAVTVTRATVAKRQVPLALLSFSTSYAISGCSMLGIWAHALPRHLMFFFGLGTLLGARASANTWKFGGFSNNWCAVPEVVWRGKSVSSLLLPITLGVSLIIRGLLNDTIPQLAYVPPVEGRNVYDETLRYYRDFDYDEGAGPSGTQHEAVPGDDNDGSTSSVSSYDVVTNVRDVGISTNGEVTGEEETHSPRSVQYTYVEEEVAPSAAVAERQGDPSGSGTADAMAFVESVKKGVDDVFHQQSSGETAREVEVDGKGLLPESVVGEAPTQERGRAADGNTAQTAVNEGDREPVQSSLVSSPQADIPKVTQSEVHAQKEVKQEVPLATVSGATPIVDEKPAPSVTTRGVKIIDKGKAVAHVAEKKQVQVEQPKQRSLTINEGKAGKQLCMFRTCSCGVQLDVYNEATIATRFSNAFTFVDNLKGRSAVFFSKLGEGYTYNGGSHVSSGWPRALEDILTAIKYPSVFDHCLVQKYKMGGGVPFHADDEECYPSDNPILTVNLVGKANFSTKCRKGGKVMVINVASGDYFLMPCGFQRTHLHSVNSIDEGRISLTFRATRRVFGVGRMLQLAGGVSDEKSPGVPNQQPQSQGATRTITPKSGGKALSEGSGREVKGRSTYSIWCEQDYVRKCEWLRADNPVMALEPDYTPMTFEVVKTGTSEDAVVEYLKYLAIGIERTYRALLMARNIAVTTAEGVLKVPNQVYESLPGFHVYKSGTDLIFHSTQDGLRVRDLPYVLIAEKGIFTKGKDVDAVVALGDNLFVCDDILVFHDAINLIGALKVARCGMVGESFKSFEYKCYNAPPGGGKTTTLVDEFVKSPNSTATITANVGSSEDINMAVKKRDPNLEGLNSATTVNSRVVNFIVRGMYKRVLVDEVHMMHQGLLQLGVFATGASEGLFFGDINQIPFINREKVFRMDCAVFVPKKESVVYTSKSYRCPLDVCYLLSSMTVRGTEKCYPEKVVSGKDKPVVRSLSKRPIGTTDDVAEINADVYLCMTQLEKSDMKRSLKGKGKETPVMTVHEAQGKTFSDVVLFRTKKADDSLFTKQPHILVGLSRHTRSLVYAALSSKLDDKVGTYISDASPQSVSDALLHTFAPAGC
What are the official names of this protein?
Replicase protein 1a.
Protein: GLYA1_VIBCH
Sequence: MLKRDMNIADYDPELYAAIQEETLRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDKAEALAIDRACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMSLAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMEALALEHKPKMIIGGFSAYSQIVDWKRMREIADKVGAYLFVDMAHVAGLIAAGVYPSPVPFAHVVTTTTHKTLAGPRGGLILSNAGEEMYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEAMEPEFKEYQARVVKNAKAMVAQFQERGYKIVSNSTENHLFLVDLIDKNITGKEADAALGAANITVNKNSVPNDPRSPFVTSGIRVGTPAITRRGFTEQDAKDLANWMCDVLDNINDQGVIEATKQKVLAICQRLPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 1, SHMT 1, Serine methylase 1.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y8960_DICDI
Sequence: MKVLVKQLMSKSLFTINLDTTLDVALKSLNANSIHRLPVVDNDGNLKGIITDRDLRLATDSPFLPENNEDRLEKLRLHKVSSIMKQNPVTIEDFSPVVEAAKLMRVTNVGGLPVLDKKGRLIGMVTRSDLLDLLIKVLEPVPPQS
What are the official names of this protein?
CBS domain-containing protein DDB_G0289609.
Protein: CAV2_LOXAF
Sequence: MGLETEKADVQLFMDDDAYSRHSGVDYADPEKFGGSGPDRDPHRLNSHLQLGFEDVVAEPVSTHSFDKVWICSHALFEISKYVVYKFLTVFLAIPLAFAAGILFATLSCLHIWIIMPFVKTCLMVLPSVQTVWKTVTDVVIAPLCASVGRSFSSVSLQLSHD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Protein: Y995_CALS8
Sequence: MLKKDATYYIVEESVLPEVFLKVIKAKELLEKGEVKAVNEAVRLVGISRSAFYKYKDCIFPFFESSRGKIITLALVLQDVPGILSKILNIISDTNANILTINQNIPLGGIATVTISIRTSDMTKSVKELIQEIERVDGVKKIEILGREEY
What are the official names of this protein?
UPF0735 ACT domain-containing protein Csac_0995.
What is the protein family that this protein belongs to?
Belongs to the UPF0735 family.
Protein: GPA1_EMENI
Sequence: MGCGMSTEDKEGKARNEEIENQLKRDKMMQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFKEIIYSNTVQSMRVILEAMESLELPLEDARNEYHVQTVFMQPAQIEGDSLPSEVGNAIAALWQDAGVQECFKRSREYQLNDSAKYYFDSIERIAQSDYLPTDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGADYAAACDYILNRFVSLNQAEQKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRLCGLI
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(q) subfamily.
Protein: PCKA_SHEPC
Sequence: MADGLHRVHYNPSTAQLVEFALLRGEGELTANGALVAKTGARSGRSPGDRFIVKEPSSEADIEWGPVNQAFEPGAFEGLWARVEAYLADKELFVSDLEVGADTEHYQPVRVTTQYAWHQLFARNLFIIPEEFNRKDKPVWQIINAPDFVCDPARDGTNSDAAVILNFAERKVLLAGLKYAGEMKKSMFSVQNFLLPAQGVLPMHCSANVGKDGDTTLFFGLSGTGKTTLSADPKRFLIGDDEHGWAPGGVFNIEGGCYAKCIDLSQKNEPVIWDAIRFGTVLENVVMDEHRVPNYKDSSLTENTRAAYPLEHIAQRKEDKCGAEPHAVVFLTCDVSGVLPPVSILTKEQAAYHFLSGYTAKVGSTEIGSTSAIQSTFSTCFGAPFFPRPAGVYAELLMKRIESFGSQVYLVNTGWTGGPHGVGKRFDIPTTRAIVDAIVSGELKDVETIHLDTLNLAVPVAVTGVDSNLLNPINTWGDKALYAEYAQKLAEAFTKNFAKYQVSDAIRHAGPKA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_METPB
Sequence: MRLSRYFLPILRETPKEAEIVSHRLMLRAGMIRQEAAGIYAWLPLGLRVLNKVCDVIRAEQDRAGAVEILMPTIQAADLWRESGRYEAYGKEMLRLKDRHERELLYGPTAEEVVTEIFRASARSYKDLPKNLYQISWKFRDEVRPRFGTMRSREFLMKDGYSFDLDQAAARHSYNKVFVSYLRTFETLGLRAIPMRADTGPIGGDLSHEFIILAKTGESEVFCDRAYLDMPVPPPSVDFDDVAGLQGVVDSWTSHYAATDEMHDEAVFAEVPEASRLSARGIEVGHIFYFGTKYSTPMKAVVTGPDGQERPVHMGSYGIGPSRLVAATIEASHDEAGIIWPDAIAPFDVALINLKVGDAACDAACAEIQSALETAGLSVLYDDRDERPGAKFATADLIGLPWQVIVGPKGLAEGKIELKRRASGERETLDPVDLPARIRRV
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4LM_LEMCA
Sequence: MPSISTNIILAFITALLGMLIFRSHLMSSLLCLEGMMLSMFILSTLTILSLHFTTSFMMPILLLVFAACEAAVGLALLVTVSNTYGLDYIQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NADK_FRATM
Sequence: MAFKYHKVAIVGKHYKKEVSQMVETLYAYLQQQGLEIIIENDTAADTSLVNVAIASLKEIALRCDVAIVVGGDGNFLKASRLLALYSNIPVIGINKGKLGFLTTLAADDNALKNDLYAILKGDSSVTKMSMLKYRVDNNLRAPLEASIALNEIAITASRGLMFGLKVFIDGRYAFDQRGDGLIVSTPTGSTAHAMSAGGPILNPNQNSVVLVPICSHSLNSRPLVISDESVIDIYITDYNDPEPVLSIDGRHDTILKAHQKVTIQKARKKVTVLHTKDYNYYDTLREKLGWSKVLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIMD_ASPJA
Sequence: MSDRTRTTRYANGSLRTCQNCARAKIRCIRSVPTGSCDRCERLRKTCQFQPGRRANAGPSLSESKDRRIDALEAKLDRLLAQSTSATVSEASIDDKSPTTTPTTPRPPPDVIDSGLLTLEAASLLLQDYQRTLMPYCPFVMVPSPATAATLRRDKPFLFLAILTAALYDNMPLQRTLELEVKRTIGRCMIFDGPVSFDMLQGLLVHLAWCQYHSRPRRFSQYLHLAISIITDLQLDRAPEDRFWRTRVDFNGELDREISWGREERRAVVGFFWFSSSISQILQKRSSFSFIPYLETSCELLASTAEYDSDQHLLQLIQLQRLSERIIVASGQHTSEPHDADALEQCYRDRRSELDLYLAQLPFPLTDSHLLMMQYHTVELYLCQVTLFDHKPSAQRPRHDSPFPIEALRMGLTAARTLLDFYISLPLRREVAFNNAGWVQLGFVVTLACKLAVAAADPHIHPHMADLTRALDLSTMLSRCILRIQALVTSQMDARGDRDVFYHYEKRLKRAQWWFESRSLSRSQQQRNEPLPVAGAGEASSPRNARIAEIPAEEEFQVGYAAVSGDGFDFQWPGLFPDPTFDDMFGDWMAQGSSGFDD
What is the function of this protein?
Transcription factor that, with himB, probably co-regulates the him gene cluster that mediates the biosynthesis of himeic acid A, a ubiquitin-activating enzyme (E1) inhibitor.
What are the official names of this protein?
Transcription factor himD, Himeic acid A biosynthesis cluster protein D.
What are the subcellular locations of this protein?
Nucleus.