PharMolix/UniProtQA huggingface dataset:
Protein: ASSY_RENSM
Sequence: MLKMHPNINKYEGVPVTDRIVLAYSGGLDTSVAIGWIGEATGAEVIAVAVDVGQGGESLETVRQRALGCGAVEAYVADARDEFANEYCMPTLKANALYQGHYPLVSAISRPVIVKHLVKAAREFGATTVAHGCTGKGNDQVRFEVGIQTLGPDLKCIAPVRDLALTRDKAIEYAERNNLPIETTKKNPYSIDQNVWGRAVETGYLEDIWNAPTKDIYDYTATPEFPPAPDEAVISFRAGVPVALDGVLLSPLQVIQELNRRAGAQGVGRIDVVEDRLVGIKSREIYEAPGAMTLITAHKHLEDVTIEREQARFKATVSQRWAELVYDGQWFSPLKRSLDVFIDDTQKYVSGDIRVVLHAGVASVNGRRTDTGLYDFNLATYDTGDTFDQSQARGFIELWGLSAKTATTRDERVAASGENA
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPE_VIBPA
Sequence: MTDSPVLALAKDLISRQSVTPEDAGCQDLMIERLKALGFEIEVMVFEDTTNFWARRGNEAPLFAFAGHTDVVPAGKLEQWDTPPFEPTIIDGYLHGRGAADMKGSLAAMVVAVERFIAEHPDHKGSIGFLITSDEEGPFINGTVRVVEALMERGENIDMCIVGEPSSTEIVGDVVKNGRRGSITGDLTVKGTQGHVAYPHLANNPVHASLLAIHELATTEWDKGNDYFPPTSFQIPNVSAGTGASNVIPGEFNVQFNLRFSTELNNDTIVQRVTETLDKHDLNYDLHWTFNGDPFLTDTGALLDAVVAAVAEVNNTKPALLTTGGTSDGRFIARMGGQVVELGPVNATIHKVNECVKVDDLEKLTDMYENTLKHLLAK
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: PANB_PELPD
Sequence: MSDMRKKVTIPDILKMKQERRRITMMTAYDYPFARLVDSGGVDAILVGDSLGVVFSGHDNTLSVTMDEMIYHTRAVARAKPQAVLVTDMPFMSYQVSVEEACRNCGRMIQEGGAQAVKIEGGMNMSHVIRAVTSIDIPVMGHIGLTPQSIHRMGGYRVQGRKEQAERIMEDALAVQAAGAFSIVLEGIPSSLAASITAELSIPTIGIGAGPDCDGQVLVIHDILGLCEKYSPKFVKRYAELAPVITDAVNRYVEEVRSGAFPTEEHSFN
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_HERA2
Sequence: MVRIRLRRMGMKHKPAYRVVIADSHAPRDGKFIETIGHYNPQAQPKVVFIKEDRARYWLSVGAQPSDTVVRLLKNLGVVDAEGKLIGEAPAKVEAPVKKAKKAVSKAAVAPVAVAAPVKAEAEAGEFAGSVRPLADGSAPEGYAIKGNQNSMLYHVPGSRYYNSTVAELWFDTVESAEAAGFRAPGQKSAE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: MEX3B_HUMAN
Sequence: MPSSLFADLERNGSGGGGGGSSGGGETLDDQRALQLALDQLSLLGLDSDEGASLYDSEPRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVAMARREIISAAEHFSMIRASRNKNTALNGAVPGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEAHIALRTGGIIELTDENDFHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTPGRKPFSSYRNDSSSSLGSASTDSYFGGGTSSSAAATQRLADYSPPSPALSFAHNGNNNNNGNGYTYTAGGEASVPSPDGCPELQPTFDPAPAPPPGAPLIWAQFERSPGGGPAAPVSSSCSSSASSSASSSSVVFPGGGASAPSNANLGLLVHRRLHPGTSCPRLSPPLHMAPGAGEHHLARRVRSDPGGGGLAYAAYANGLGAQLPGLQPSDTSGSSSSSSSSSSSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCMECANRICEKSEPECPVCHTAVTQAIRIFS
What is the function of this protein?
RNA-binding protein.  May be involved in post-transcriptional regulatory mechanisms.
What are the official names of this protein?
RNA-binding protein MEX3B, RING finger and KH domain-containing protein 3, RING finger protein 195.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3- 3.
Protein: RL18_PSYWF
Sequence: MFDKKAARLRRAKKTRAHIRHLGVHRLVVNRTPRHIYAQIISPTGGEVLAQASTLDASLRSGATGNVDAAAAVGKLIAERGTSAGITKVAFDRSGFKYHGRVKALADAARENGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: YBEY_TOLAT
Sequence: MSVTLDLQIACADSTGLPSETQFQQWLDTAVLPFQQEAEVTIRLVDEAESNELNLTYRGKDKPTNVLSFPFECPPEVEDFPLLGDLIICRQVVEKEALEQQKTLESHWAHMVIHGSLHLLGYDHIEDEEAEEMEALEKEFMQTLGFPDPYKDDEI
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC63_MOUSE
Sequence: MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDSTSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLIIMARSREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHSLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPTEDGQSDANKIKAKGGWQQKNKGPKKMPKSKKKKPLKKKPTTVPLPQAKQQKQKQANGVVGSEAAIKEEEDDISDKGSDSEEEETNRDSQSEKEDGSDRESDREQDEKQSKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEGGD
What is the function of this protein?
Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059).  Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides.  May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity).  Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (PubMed:21685914).
What are the official names of this protein?
Translocation protein SEC63 homolog.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ATPG_STAHJ
Sequence: MASLKEIDGRIKSTKKMKQITKAMNMVSSSKLRRAEKNTKQFEPYMEKMQDAITAIAGASKNSSHPMLRPRQVQRSGYLVITSDKGLAGAYSSNVLKRLINDIKEKHTSSDEYSIIVLGQSGVDFLKNRGYEIENSLVDVPDQPSFKSIQAIAKHAIDLFSEEHIDELKIYYSHYVSVLENKPTTKQVLPLSREDSSQGQGQMSSYEFEPDKESILSVILPQYVESLIYGTILDAKASEHAARMTAMKNASDNATELIDDLSLQYNRARQAEITQQITEIVGGSAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: REN_ICMV
Sequence: MDSRTGELITAAQAMNGVFIWEVPNPLYFKIIQHDNRPFVMNQDIITVQIRFNHNLRKALGLHQCWMDFKVWTTLQPQTWRFLRVFKTQVLKYLDSLGVISINTIVKAVEHVLYNVIHGTDRVEQSNLIKLNIY
What is the function of this protein?
Increases viral DNA accumulation.  Enhances infectivity and symptom expression (By similarity).
What are the official names of this protein?
Replication enhancer protein, REn, Protein AC3, Protein AL3.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae replication enhancer protein family.
Protein: Y4061_BACC2
Sequence: MKLGIVIFPSKMIQDKANGLRKRYDPHYALVPPHITLKTPFETQDEQLESIVNELHTIAGKTNPFTLHVGKVGSFAPVNNVLYFKVEKTPELTFLNEEMHGGLFTQEREYAFVPHLTIGQGLSDAEHADVLGRLRMKDFYYEQPIDRFHLLYQLENGTWTVHETFHLGKGNN
What are the official names of this protein?
Putative phosphoesterase BCG9842_B4061.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. YjcG family.
Protein: HCP_ECO8A
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINHDVDSFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLAVDANARVDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECSMEIGQMNFKVMSILDAGETGKYGHPTPTQVNVKATAGKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGAYDDRIWTRSIVGWPGVRHLDGEDFSAVIAQAQQMAGFPYSEIPHLITVGFGRQTLLGAADTLIDLVSREKLRHIFLLGGCDGARGERHYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFLTPDLLAVLNEKFGLRSITTVEEDMKQLLSA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FL2D_XENTR
Sequence: MTNEEPLPKKVRLNESDFKVLPREELLQRWKQFEAYVQALENKYTDLNSNDVTGLRESEEKLKQQQQDSARRENILVMRLATKEQEMQECTTQIQHLKQVQQPSVAQLRATMVDPAINLFFIKMKAELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKDSRQQLSQFQQQIQTSGNRTPSSESKDEGETSGKDCGRILNGPSNGGSSHQRTHSSVGLYREGSSTEEDFSASPINEGKLPNHSEERTSRGGSSYMNQLSTGYESVDSPTGSENSLTHQSNDTDSNHDSQEEKPVSGKGNRTVSSRHLQNGLDSSVNVQGSVL
What is the function of this protein?
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.
What are the official names of this protein?
Pre-mRNA-splicing regulator WTAP, Female-lethal(2)D homolog, WT1-associated protein, Wilms tumor 1-associating protein.
What is the protein family that this protein belongs to?
Belongs to the fl(2)d family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm.
Protein: CFT1_CRYNJ
Sequence: MHALHQTLLPSSSIHHSLFLPHFTPSTIYPLPKPPAALDTLDVKVIGNLVVAGAEVLRVFEIREESVPIIENVKLEEDVAEGEKDVQMEEVGDGFFDDGHAERAPLKYQTTRRLHLLTQHELNGTITGLAATRTLESTIDGLDRLIVSFKDAKMALLEWSRGDIATVSLHTYERCSQMNTGDLQSYVPLLRTDPLSRLAVLTLPEDSLAVLPLIQEQSELDPLSEGFSRDAPYSPSFVLSLSDMSITIKNIQDLLFLPGFHSPTIALLFSPMHTWSGRLQTVKDTFCLEIRTFDLSSGTSYPLLTSVSGLPSDSLYLVACPSELGGIVLVTSTGIVHVDQGGRVTAACVNAWWSRITSLKCSMASVSQKLTLEGSRCVFVTPHDMLLVLQNGAVHQVRFSMEGRAVGVIEVLDKGCVVPPPSDLTVAGDGAVFVGSAEGDSWLAKVNVVRQVVERSEKKKDEMEVDWDEDLYGDINDAALDEKAQELFGPAAITLSPYDILTGVGKIMDIEFGIAASDQGLRTYPQLVAVSGGSRNSTINVFRRGIPITKRRRFNELLNAEGVWFLPIDRQTGQKFKDIPEAERATILLSSEGNATRVFALFSKPTPQQIGRLDGKTLSAAPFFQRSCILRVSPLEVVLLDNNGKIIQTVCPRGDGPKIVNASISDPFVIIRRADDSVTFFVGDTVARTVAEAPIVSEGESPVCQAVEVFTDTTGVYRTFEPSKSESSEPISHQIDSENKPNITNGINGTTARSARQTQLTPQQIKRLQEQEPAITTEAPSMETAINSPHGTQWLALVTRGGELQIRSLPDLQIVLQSEGLASSAPSFTDDLGENPGYVLGEKREEGEEEDEIIQMVFCPIGKGTVRQHLLALHHSGRLNAYEAQPRFTVDASSHSRRSLAVRFRKVHTQLLPISGGVGTTNGNARLPYTIVPFNNIEGLTGAFITGEKPHWIISSEAHPLRAFALKQAAMAFGKTTHLGGKGEYFIRIEDGSFICYLPPTLNTDFAIPCDRYQMERAYTNITFDPTSAHYVGAASIEVPFQAYDEEGEIQLGPDGPDLIPPTNQRSTLELFSQGSDPWKVIDGYEFDQNEEVMSMESVNLESPGAPGGYRDFIAVGTGFNFGEDRATRGNTYIFEILQTVGPQGGGGPGSVPGWKLVKRTKDPARHPVNAVNHINGYLLNTNGPKLYVKGLDYDSQLMGLAFLDIQLYATTVKVFKNFMLIGDLCKSFWFVSLQEDPYKFTTISKDLQHVSVVTADFLVHDGQVTFISSDRNGDMRMLDFDPTDPDSLNGERLMLRTEYHAGSAATVSKVIARRKTAEEEFAPQTQIIYATADGALTTVVSVKDARFKRLQLVSDQLVRNAQHVAGLNPRAFRTVRNDLLPRPLSKGILDGQLLNQFALQPIGRQKEMMRQIGTDAVTVASDLQALGGFW
What is the function of this protein?
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.  Involved in poly(A) site recognition.  May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).
What are the official names of this protein?
Protein CFT1, Cleavage factor two protein 1.
What is the protein family that this protein belongs to?
Belongs to the CFT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EASE_ASPFU
Sequence: MSHRILCVAFCVCSLVAVSSIYSPPFNHPIVYSNNAICFQLSTWRIPQLYLAVLIRRFDLSLSTRGVMLAVTVGVGSSQHHSQRSGLSLTFAMTPSMITLLVKTCVISQRTAVGEPHRPGWVWEVGRTEDETCHAHSPRGAPCHQGRIPLYSAAVESVDQIQVAVRFAQRHRLRLVVRNTGHDTAGRSSGSDSFQIHCHRMKQIEYHDNFRALGSDIDRGPAVSVGAGVTLGEMYARGARDGWVVVGGECPTVGAAGGFLQGGGVSSFHSFIDGLAVDNVLEFEVVTAKGDVVVANDHQNPDIFWALRGGGGGTFGIVTRATMRVHLNSPVCVSEVAVSGLRNNSLLWTKGITGLFSILRSFNQQGIPGQFILRPLSKDQVNASLTLYSLNTDDTRRSAENMLSIRNILESTTLPFTLASRCLPKISDALRKGPDMLPVNYGIITGSVLVSEDLFNSEEGPLHLAKQLEHFPMGPMDLLFTSNLGGNVSANTGKKHRDTSMHPGWRQAAHLINFVRSVSTPTAHEKARSLEELHSVQMRQLYDIEPDFRVSYRNLGDPLESDAAQVYWGPNYKRLLEIKRKWDPEDLFFSQLGVGSEGWTEDQMCKRQQRLQQMLQYLMSSIAQRVYR
What is the function of this protein?
FAD binding oxidoreductase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid (PubMed:15933009, PubMed:23435153, PubMed:26972831).  DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:15870460).  The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity).  The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by EasD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:20039019, PubMed:20526482, PubMed:21409592, PubMed:23435153).  EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:20526482).  EasG then catalyzes the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:20526482).  Hydrolysis of festuclavine by easM then leads to the formation of fumigaclavine B which is in turn acetylated by easN to fumigaclavine A (PubMed:26972831).  Finally, easL catalyzes the conversion of fumigaclavine A into fumigaclavine C by attaching a dimethylallyl moiety to C-2 of the indole nucleus (PubMed:19672909).
What are the official names of this protein?
FAD-linked oxidoreductase easE, Ergot alkaloid synthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: EFG_STRZP
Sequence: MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAHPIQLPIGSEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYLDQAQEYREKLVEAVAETDEELMMKYLEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVIDYLPSPLDIPAIKGINPDTDAEETRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVLQSGSYVLNTSKGKRERIGRILQMHANSRQEIETVYSGDIAAAVGLKDTTTGDSLTDEKAKIILESINVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVISGMGELHLDVLVDRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDVWIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLYDGSYHDVDSSETAFKIAASLALKEAAKSAQPAILEPMMLVTITVPEENLGDVMGHVTARRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQEEIIKKNKGED
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLUA_SALTI
Sequence: MGMENYNPPQEPWLVILYQDEHIMVVNKPSGLLSVPGRLEAHKDSIMTRIQRDYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYNVVEFAADNTARVVLKPITGRSHQLRVHMLALGHPILGDQFYASPEALSLAPRLQLHAEMLTITHPAYGNSMTFKVPADF
What is the function of this protein?
Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
Dual-specificity RNA pseudouridine synthase RluA, 23S rRNA pseudouridine(746) synthase, Ribosomal large subunit pseudouridine synthase A, rRNA pseudouridylate synthase A, rRNA-uridine isomerase A, tRNA pseudouridine(32) synthase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: TB15C_HUMAN
Sequence: MSDKPDLSEVEKFDRSKLKKTNTEEKNTLPSKETIQQEKECVQTS
What is the function of this protein?
Plays an important role in the organization of the cytoskeleton.  Binds to and sequesters actin monomers (G-actin) and therefore inhibits actin polymerization.
What are the official names of this protein?
Thymosin beta-15C.
What is the protein family that this protein belongs to?
Belongs to the thymosin beta family.
Protein: RNPH_SHEPC
Sequence: MRPSNRTPAQTRPITITRQFTAHAEGSVLVEFGETKVLCTASFTEGVPRFLKGQGQGWVTAEYGMLPRSTHSRMDREAARGKQSGRTQEIQRLIGRALRACVDMKALGENTIVIDCDVIQADGGTRTASITGACVALVDALNWARGKGIIKSNPLKFLIAAVSVGIYKGEAISDLEYIEDSAAETDMNVVMTETGKIIEIQGTAEGEPFTHEELIELLGLAKNSIREIVDVQKAALN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: APG2_ARATH
Sequence: MDRCTSSFLLLTLVSTLSILQISFAQLVPAIMTFGDSVVDVGNNNYLPTLFRADYPPYGRDFANHKATGRFCNGKLATDITAETLGFTKYPPAYLSPEASGKNLLIGANFASAASGYDDKAALLNHAIPLYQQVEYFKEYKSKLIKIAGSKKADSIIKGAICLLSAGSSDFVQNYYVNPLLYKVYTVDAYGSFLIDNFSTFIKQVYAVGARKIGVTSLPPTGCLPAARTLFGFHEKGCVSRLNTDAQNFNKKLNAAASKLQKQYSDLKIVVFDIYSPLYDLVQNPSKSGFTEATKGCCGTGTVETTSLLCNPKSFGTCSNATQYVFWDSVHPSEAANEILATALIGQGFSLLG
What are the official names of this protein?
GDSL esterase/lipase APG, Extracellular lipase APG.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted.
Protein: GACA_PSEPH
Sequence: MIRVLVVDDHDLVRTGITRMLADIDGLQVVGQAESGEESLLKARELKPYVVLMDVKMPGIGGLEATRKLLRSHPDIKVVAVTVCEEDPFPTRLLQAGAAGYLTKGAGLNEMVQAIRLVFAGQRYISPQIAQQLVFKSFQPSSDSPFDALSEREIQIALMIVGCQKVQIISDKLCLSPKTVNTYRYRIFEKLSISSDVELTLLAVRHGMVDASL
What is the function of this protein?
Member of the two-component regulatory system GacA/GacS which controls the expression of secondary metabolites and extracellular products.  Acts (probably primarily) by activating expression of CsrA1 and CsrA2 antagonist small RNAs (sRNA) RsmX, RsmY and RsmZ which bind to and prevent translation repression by CsrA1 and CsrA2 (PubMed:11807065, PubMed:14622422, PubMed:15601712, PubMed:16286659).  Involved in the regulation of secondary metabolism and in the synthesis of the antifungal factors cyanide, 2,4-diacetylphloroglucinol and pyoluteorin (PubMed:1311842).  Involved in synthesis of the autoinducing signal (unrelated to N-acylhomoserine lactones, induces the Gac/Csr cascade) (PubMed:16286659).  Exercises positive post-transcriptional control over the hcnABC and aprA genes; acts upstream of CsrA2 (rsmA) (PubMed:10570200).  Controls expression of csrA1 (rsmE) and csrA2 (PubMed:15601712).
What are the official names of this protein?
Response regulator GacA, Global activator, Global antibiotic and cyanide control protein.
Protein: MURD_CHRVO
Sequence: MDYANRHVTVVGLGGSGLAAARYLAAHGARVRVADANPSAERLAELERCLPGVEVMVGAFDDATFAGAELLVVSPGVPLANPAIAAFRRAGGEVVGDIEILARAIQGDGSKVIAITGSNGKSTVTSLVGHLCEAAGLDTVVAGNIGLAVLEALLAREQSGKRPDVWVLELSSFQLESTFSLAADAATVLNISEDHLDRYADLLDYAHAKTRVFNGKGVQVLNKDDALVRAMVRPGHPVKWFSLNGAADYALARNGGYWLKVDGEKVFDCADMQLQGLHNAANALAALGLCQGIGLPLEKLLDGLKTFRGLAHRVELVDEFDGIAFIDDSKGTNVGATEAALNGMTRQVVLIAGGDGKGQDFAPLKPACQRIARAVLLIGRDAGRIEAALEDSGLALERCDTLEEATRRAAALARPGDVVLLSPACASLDMFKNYAHRAQVFIDTVAAVKAARA
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_METMJ
Sequence: MRLPIRAVTPETESAEIVGWVHEVRDLGGLSFFLIRDRTGIIQVTIPKKKVPAEILDTARSVSRESVVRVRGTVKAIEKAPGGREIVPEELEIISTAESPLPLDVAEKVSAEMDTRLDSRFLDARKPRVRAIFFIRSAVTCAATAFLASRGCINIATPKIVAAATEGGTELFPIAYFEKEAFMNQSPQLYKQMMMAAGFEAVFEIGPIFRAEEHNTVRHLNEATSLDVEVSFADHNDVMELLEDLIVHVYDHVAKDCSEHLAELEIDLKVPSKPFPRIPYAEAIEIANKTIEEKLAFGDDLSPAAERAIGDTVGQHYFIVDWPTDIRPYYAMPYPDRPEFCKAFDLMHPRMELSSGAQRIHDHDLLVERISAKGLSPESFEFYLKPFRYGMPPHAGWGLGIERLVMTMLDLPNIREAVLFPRDRHRLMP
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHP2_BOVIN
Sequence: MTKIKADPDGPEAQADACCGERTYHELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFINKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQALPPPM
What is the function of this protein?
Required for ribosome biogenesis and telomere maintenance.  Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs.  May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit 2, Nucleolar protein family A member 2, snoRNP protein NHP2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).