PharMolix/UniProtQA huggingface dataset:
Protein: CYAY_SHEB5
Sequence: MAITDTEFHQLADDMFQAIENAIETAIDEQDADVDIDASGNVLQLEFVDGSKIVINKQEPLHEIWVATRFGGYHFGFVEGKWMDGRNGGEFMPFVQESIERQGGIKLSF
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: LPXD_SYNS9
Sequence: MRFSTLLKDLQTGEAELRWSQCGADPILAGAASLEQAKGDQLSFLEKGNALIAALTETGAGALLLPDQPDLIQCASERGIAFAVLANPRLAFAEALERLHPRLRPLAEIHPSAVVDERAVVGPGTFIAPRVCIGASSRIGANCIVHPGVVIYDDVEVGEGCELHANAVLHPGSRLGRGCVVNSNAVIGSEGFGFVPTPRGWRKMPQTGQVVLEDGVEVGCGSTIDRPSVGETRIGAGSKIDNLVQIGHGVTTGRGCALASQVGIAGGAKLGHGVILAGQVGVANRAVVGDGAIASSKSGIHGEVAPGEVVSGYPAIPNRLWLRCSAAFSKLPEMAKTLRELKRDISQ
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: MURI_SHEON
Sequence: MSQPILVFDSGIGGLSVLAEIRKRLPHHDYCYVFDNARLPYGELEEQELVSGCVALISQLVERTHACIVVVACNTASTVVLPALRAKLHIPVVGVVPAIKPAALLSKSKRIGLLATPGTVKRHYTHELISQFADDCHVELFGCSELVMMAEHKIATGQLGIARLTQILSPVVDANLDVLVLGCTHFPMLRDELQQVLGLGVTLLDSGAAIAKRVDTLLAHGKNISHNSEYERNGSLMRAFYTKAEITEGLATTLADCGFSTLERITTINSNSD
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: THII_KLEP7
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKNYDETLAVVRHWDHIEVRAKDENQRPAIRDALTRIPGIHHILEVEDVPFTSLHDIFEQTLPLWREALEGKTFCVRVKRRGKHEFTSIEVERYVGGGLNQHIETARVKLTDPDVTVNLEIENDRLLLVKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKVDDGQMGVVLKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISHDKEHIIDLAREIGTEDFARTMPEYCGVISKSPTVKAVKAKIEAEEEHFDFSILDKVVEEASNIDIREIAQQTEETVVEVETVTGFGANDAILDIRSIDEQEDKPLKVEGVEVVSLPFYKLSTKFGDLDQSKTWLLWCERGVMSRLQALYLREQGFSNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_PSEAB
Sequence: MPAFFVTGTDTEIGKTTIAAGLLHAARRAGLSTAAAKPVASGCEPTAQGLRNGDALALLGQCSLALAYEQVNPLAFAPAIAPHLAAREAGVELSAARLHEAVREVLALQADLTLVEGAGGWRVPLQGRENLSDLARLLALPVVLVVGVRLGCINHALLSAEAILGDGLALAGWVANVVDPATSRLEENLATLAERLPAPCLGRVPRLEEATPAAVAAHLDLRPLGIGL
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHOSP_IHNVW
Sequence: MSDGEGEQFFNLEGEDILRLESRLKTPRNDGQIGKNPRRRKEDQAPQEEPKKTTRRPDKNKGLSQLEQLILKYVEEESCQDALKDFGGLIANIRQAHQAEMTSHLEKVATEHRANLQALTKSQQEHEKVSKEILSAVIAIRSNLNENHSPLPKPLDPDQVKAARALGFGIGYRTALNVFDRIKGVTPDNAGSQEVKNLAIRAAEEDEYEGSPTFFRKVIDAVKKRMKQGQ
What is the function of this protein?
Essential component of the RNA polymerase transcription and replication complex.  Binds the viral ribonucleocapsid and positions the L polymerase on the template (By similarity).
What are the official names of this protein?
Phosphoprotein, Protein P, Protein M1.
What is the protein family that this protein belongs to?
Belongs to the novirhabdovirus protein P family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: LIPM_LYSSC
Sequence: MTTWYFLNSGKCSPSFNMALDEALLDWHSEGLIPPVIRFYEWEPATLSIGYFQQAKKDINLDAVREQGLGFVRRPTGGRAVLHEHELTYSVIVTESYPDMPESVTEAYRVLSEGILQGFHNLGMDAYFSVPDTEEKRADLKSPKSAVCFDAPSWYELVVEGKKIAGSAQTRQKGVILQHGAILLDLDQEKLLSVFNFSSEEAKDRMRRKLPEKAVAINSLVDEPVTVEQCVTAFRDGFAKSLQIELKPFTLSEEQLEYVRALEEKKYACDEWNFKK
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation.
What are the official names of this protein?
Octanoyltransferase LipM, Octanoyl-[acyl-carrier-protein]:[GcvH] N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the octanoyltransferase LipM family.
Protein: NU2M_CYACA
Sequence: PLAGFFSKLFVFTACLQSSLYFLTFIGILLSGITAFYYIQIIKIIYFGRLNFWSIYIPIDKSNAVMISITTLLLILFFADNSIFITSNLVSLNIFHFLK
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ZAPD_BURL3
Sequence: MILYEYPFNERIRTLLRLEDLFERFAFFLAQEDPREHHVALTTLFEIAEVTGRADLKSDLMKELERQRQTLAPFRGNPGIEQNALEAVLGEIEQTLANLAQMQGKTGQHLVDNEWLASIRSRAVIPGGTCKFDLPSYYAWQQWPAEQRRQDIAKWILPMLPLRDAVTIVLRLARESGQASKVMAMQGSYQQMLSGRTYQLMQVRVPPELRVIPEASANKYMLWVRFTVQDGDVRPRAVDIDVPFHLTLCNL
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: CDC1_YEAST
Sequence: MVYRNRSKSVLSTHSKKSDDKAHYKSRSKKKSKSRSKKRLRIYWRYISIVWILWLGLISYYESVVVKRAMKKCQWSTWEDWPEGAESHRVGLFADPQIMDEYSYPGRPQIVNYFTRVIVDHYHRRNWKYVQYYLDPDSNFFLGDLFDGGRNWDDKQWIKEYTRFNQIFPKKPLRRTVMSLPGNHDIGFGDTVVESSLQRFSSYFGETSSSLDAGNHTFVLLDTISLSDKTNPNVSRVPRQFLDNFAMGSHPLPRILLTHVPLWRDPEQQTCGQLRESKEPFPIQKGHQYQTVIENDISQEILTKIQPEILFSGDDHDHCQISHSYPFQGKTKNAQEITVKSCAMNMGISRPAIQLLSLYNPSDLTMVNAGGEYASKTYQTELCYMPDPYKAIRMYLWGLLFSAAFIAYMHFFPKSFNNRVATIMNRVFTRPDGNTSDLPLPTSISKSKSKKSLTHSKYAVNDTRSIKQFLVNAIVLFVSVMPIFIYFYTVV
What is the function of this protein?
Probable metallophosphoesterase which may participate in recombinational repair of double -strand breaks.
What are the official names of this protein?
Cell division control protein 1.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. MPPE1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GATC_GLUDA
Sequence: MSLDPATVRRIARLARIGIDESDLHALQGELNGILGWIEQLNEVDIDGVEPMVGTGHAALRMREDVVTDGAARDAVLSNAPDAAGPFYTVPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: RM03_SCHPO
Sequence: MSFISRSTTTFRRSISMKDYARVRWYSNSGKSLIENILSSKIAISKVYTLKKRIGLPESYPMKVLVQALIDKTVVQNPQYSNEKLWSIGKVFGDFYVLEYIKCKYPRLPEEAVHGMQNGWMGSKALSQLATIWGLEVQRREEGLQESFGKVLAKRADPEMLRKPGEIYKDEAARRAILAILGGVYLHQGFNDTKKFINDHILSKQLDPRTMLQLQWPRRQLSRLCKRLSLKEPVYRIIAETGRKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSLISYYIHSPPFRQLPSDYLEVNDGKIPKASEPYTSIPLVSHGQLVI
What are the official names of this protein?
54S ribosomal protein L3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y1393_METJA
Sequence: MRKLIFMALLMSLLFIGTVFGYGDNGPLYVAYYEKYNITGNTTGDGLVSSTIESITGYIVINNTGTTINDTLYDVWVAVNISNNITGPEVYVNGTPKGVFIESSAPAYTNLPNANTYIHIPILPNNSYVIIKFAIDKSITGVPLIINETYSDTKIPSERLSNWSVYLNISRNVSALPATDTPVSVIMTKYLSNDPNNYGSDTWNFLNITGAIANEGSITLWDGPYFLPGYNDSLTWTGVVINTTKNATITINITGNNTYTNRTGTLMKYGFAVIFFEFNGTKSGTKIEGIYATGYGGVSATKEGPFLNASSGKYEIWYESANVSNKASSYYFNLTHVTIWAVNGSNPVILDPFNITLLIPNSKQTSSPNEILSPGSVWSSTKYAFTFDGIPVVWANCTFKVADENITLINRSINEYSTKYGSSYVVVEEIYVVGSYLIKVTKHIVPDADGTYDIYIVVENIGSVKTPEYVYVYDLIPKNFTVSDEWVNQSSMLIAEGNHTITTNPRYNLSMWWALHAIYPGADGDGNWNDTAEILANKTVVIHYKLNGTGEFYPSDAFIVGIDPTNSLLPTTSPKITTVAGTVENNSEPFLALLTLLVGLGIIIRRVM
What are the official names of this protein?
Uncharacterized protein MJ1393.
What is the protein family that this protein belongs to?
To M.jannaschii MJ1394 and A.fulgidus AF2028.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: OBG_CORDI
Sequence: MARFVDRVVLHLEAGDGGNGCASVHREKFKPLGGPDGGNGGHGGDIILTVSPQAHTLLDLHYRPHLKAQRGANGAGDHRNGARGQDLVLEVPAGTVVMSESGETLADLTSPGMTFIAAKGGFGGLGNAALASAARKAPGFALKGEPGEQHDVILELKSMADIGLVGFPSAGKSSLISVMSAAKPKIGDYPFTTLQPNLGVVDMGNDAFTIADVPGLIPGASQGKGLGLDFLRHIERTAVLAHVVDAATLEPGRDPISDIEALEEELAAYQSALDEDTSLGDLRERARIVILNKADIPDALELAEFLKEDIEEKFGWPVFIISAVARKGLDPLKYAMLDLVQQSRKKRPKQKVEERIVVRPQAVDARKKNKDFEILADPQVENGYLVVGEKPERWIIQTDFENDEAVGYLADRLARMGVEDALWKKGARAGCTVTIGEVSFEWEPTTAAGVEVQMSGRGTDMRLERNTRVSAQERKRASQVRRGLIDEYDFGDDQKVTRESANRDRWQG
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPI6_YEAST
Sequence: MYCEANPPKCTSSNTTLSGHAKPCNLMTAVKTARQATNSFSLRVTMVRNEANSALGSVTIKGLTGPCLISSSGTGSSCSTRLYVFSSDMTVLVAVSCFLIGSSDTTSL
What are the official names of this protein?
Putative uncharacterized protein OPI6.
Protein: YGFZ_YERP3
Sequence: MAYHTPFAAQPPVASSGLPLTLISLDDWALVTLTGADRVKYLQGQVTADIDALSADQHVLCAHCDAKGKMWSNLRLFYRGEGLAFIERRSLLDNQLSELKKYAVFSKVVIAPQPDAVLIGVAGSQAKTALAEIFTELPSAEHPVTQMGNSTLLHFSLPAERFLLVTDTEQAQQLVEKLAGRAQFNDSKQWLALDIEAGFPIIDAANSAQFIPQATNIQALNGISFTKGCYTGQEMVARAKYRGANKRALYWLAGNASRVPAAGEDLEWQLGENWRRTGTVLSAIQLNDGTVWVQAVLNNDLAADSVLRVRDDALGTLAIQPLPYSLAEDK
What is the function of this protein?
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs.  It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
What are the official names of this protein?
tRNA-modifying protein YgfZ.
What is the protein family that this protein belongs to?
Belongs to the tRNA-modifying YgfZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_ROSDO
Sequence: MTQTLHIVGGGMAGSEAAWQAAEMGVDVVLHEMRPKVGTFAHQTGLLGEMVCSNSFRSDDDEQNAVGLLHWEMRAAGGLIMRMADKHRLPAGGALAVDRDLFAQSVTDTLTAHPRITIEYGEISELPASGQWIFATGPLTSSKLSDAIAAQTGGAALAFFDAIAPIVYFDSIDMSRAWMQSRYDKGETEEERTAYLNCPMDKDQYEAFIDALLAADKTEFKEGETADYFDGCLPIEVMAERGRETLRFGPMKPVGLTNPHQPDVKPYAVVQLRRDNKLGTLYNIVGFQTKMKYGAQAAVFKTIPGLENASFARLGGIHRNTFLNAPTLLDEQMRLRSRPNIRFAGQITGVEGYVESAAMGLLAGRLAAAEILGISLSAPADTTATGALITHISGGAEAKTFQPMNVNFGLFPPVEGLKGGRRGRKDRYKAYTDRAKRDWQNWLEAVKEPA
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLZ3_COCLU
Sequence: MSANLEYPNGTTADAENGMWLHHILFYNKANRDDICGEKKPGQRFFGSGNDRTPLDLTDGGKNKLGYHIGHNDQFFISVELMNMHFSSQVVVLTAHWKFVEEPYSKYELGTPYWFDVASCGRSDVPATNNAIFDFISPPVRLDFHGRMAYLSNHVHDGAFLHEVKKNGKTICSVNPQYSSADGADGIVHLSHVPPCSNAGPVAPGDEVSLTASYDTTKYKPMINEDGTLEPVMGVTLAYIVKGTAPVENDSGGRLYFAVPLAAIAFIALIISGGYVIYSAKQQKAWPKWLSRRQKYQSVGTEVESFITR
What is the function of this protein?
Probable copper-dependent oxygenase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS) (PubMed:28605916).  SQS1 is composed of a 2,8-dioxobicyclic[3. 2. 1]octane-3,4,5-tricarboxyclic acid core that is connected to two lipophilic polyketide arms (PubMed:28605916).  These initial steps feature the priming of an unusual benzoic acid starter unit onto the highly reducing polyketide synthase clz14, followed by oxaloacetate extension and product release to generate a tricarboxylic acid containing product (PubMed:28605916).  The phenylalanine ammonia lyase (PAL) clz10 and the acyl-CoA ligase clz12 are involved in transforming phenylalanine into benzoyl-CoA (PubMed:28605916).  The citrate synthase-like protein clz17 is involved in connecting the C-alpha-carbons of the hexaketide chain and oxaloacetate to afford the tricarboxylic acid unit (PubMed:28605916).  The potential hydrolytic enzymes, clz11 and clz13, are in close proximity to pks2 and may participate in product release (PubMed:28605916).  On the other side, the tetraketide arm is synthesized by a the squalestatin tetraketide synthase clz2 and enzymatically esterified to the core in the last biosynthetic step, by the acetyltransferase clz6 (By similarity).  The biosynthesis of the tetraketide must involve 3 rounds of chain extension (By similarity).  After the first and second rounds methyl-transfer occurs, and in all rounds of extension the ketoreductase and dehydratase are active (By similarity).  The enoyl reductase and C-MeT of clz2 are not active in the final round of extension (By similarity).  The acetyltransferase clz6 appears to have a broad substrate selectivity for its acyl CoA substrate, allowing the in vitro synthesis of novel squalestatins (By similarity).  The biosynthesis of SQS1 requires several oxidative steps likely performed by oxidoreductases clz3, clz15 and clz16 (Probable).  Finally, in support of the identification of the cluster as being responsible for SQS1 production, the cluster contains a gene encoding a putative squalene synthase (SS) clz20, suggesting a likely mechanism for self-resistance (Probable).
What are the official names of this protein?
Probable copper-dependent oxygenase clz3, Squalestatin S1 biosynthesis cluster protein clz3, Zaragozic acid A biosynthesis cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the clz3 oxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YDFO_ECOLI
Sequence: MDQVVIFKQIFDKVRNDLNYQWFYSELKRHNVSHYIYYLATENVHIVLKNDNTVLLKGLKNIVSVKFSKDRHLIETTSNKLKSREITFQEYRRNLAKAGVFRWVTNIHEQKRYYYTFDNSLLFTESIQKTTQILPR
What are the official names of this protein?
Uncharacterized protein YdfO.
What is the protein family that this protein belongs to?
To E.coli YbcV and YcgX.
Protein: ENO_OLEA2
Sequence: MSTIVSVWAREILDSRGNPTVEVEVSLESGHSGRAAVPSGASTGSREALELRDGDKGRYLGKGVEKAVDNVMGEIAENIVGMDALRQVAVDNALIDLDGTDNKDRLGANAMLGVSLATARAAANFIGMPLYQYLGGINSKVLPVPMMNIINGGEHAPNNLDIQEFMIMPVGAPTFSEALRMGAEIFHNLKALLAADGHVTSVGDEGGFAPNLKSHDEAFRYIMRAIETAGYIPGSEVALAIDAAASEFYKDGKYHLKGENKVLSSSEMIDWLMDFTQRYPLISIEDGMAEGDWEGWQEMTVKMGDSVQIVGDDVFVTNPDILAQGIDEGVANSILIKLNQIGTLTETLDTVEMAKGAGYTTVISHRSGETEDHFIADLAVALNAGQIKTGSLCRSDRLAKYNQLLRIEEDLDDEGIYFGPYMASHFGLGEE
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SSRP_FRATM
Sequence: MSKHKVSPATIAKNKKALHDYTILEKFEAGIVLQGWEVKSIRAGKVQMVDSHVHIKHGEAWLFNCLITPLLSASTHVVADAAATRKLLLNRREINKIMGRIEQKGFTCIPLSMYWKGPRVKVEIALAQGKKVHDKRQAQKDKDWAREKDRLFKKAYK
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RL3_COXBU
Sequence: MSIGLIGRKCGMTRIFTETGSSIPVTVVEVILNRITQVKTVETDGYRAFQVAYGKKSSARVNKPLAGHYSKAAVEAGNALREFRLGNEELTEAKAGDELKVDIFKEGQVVDVRGLTRGKGFAGTVKRHNFRTQDATHGNSLSHRAPGSIGQCQTPGRVWKGKKMAGQLGNVYCTVQSQEIIKVDVERNLLLIKGALPGAPGGEVIITQSSKKRKEDK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: TGT_BACCR
Sequence: MTAIRYEFIKTCKQTGARLGRVHTPHGSFDTPTFMPVGTLATVKTMSPEELKAMDSGIILSNTYHLWLRPGHEIIREAGGLHKFMNWDRAILTDSGGFQVFSLSDFRRIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPFPATFEYMKKSVERTSRWAERCLKAHERPQDQGLFGIVQGGEYEELRRQSAKDLVSMDFPGYAVGGLSVGEPKDIMNRVLEFTTPLLPDNKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIARNGTCMTSEGRLVVKNAKFARDFGPLDPNCDCYTCKNYSRAYIRHLMKCDETFGIRLTSYHNLHFLLNLMEQVRQAIREDRLGDFREEFFEQYGFNKPNAKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: MINE_BURM1
Sequence: MSILSFLLGEKKKSASVAKERLQLIIAHERVGGRPPADYLPALQKELVAVISKYVQISNDDIRVSLERQDDLEVLEVKIEIPQA
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: PURA_MYCVP
Sequence: MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGENFALHLIPSGILTPGVTNVIGNGVVVDPGVLLAELKGLEERGVDTERLLISADAHLLMPYHVAIDKVVERYAGSKKIGTTGRGIGPCYQDKIARQGIRVADVLDPALLAEKIEGALELKNQVLVKIYNRKALDPAEVVENLLEQADGFKHRIADARLLLNEALERNETVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGASVGSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDDHGAYLAKTGGEVGVTTGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPICVGYSVDGKRTDEMPMTQSDIARAEPIYEELPGWWEDISGCRTFDELPAKARDYVLRLEDLAGAHVSCIGVGPGRDQTIVRRDVLAAR
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AR5A_PHAVU
Sequence: MASSKLLSLALFLVLLTHANSATETSFNFPNFHTDDKLILQGNATISSKGQLQLTGVGSNELPRVDSLGRAFYSDPIQIKDSNNVASFNTNFTFIIRAKNQSISAYGLAFALVPVNSPPQKKQEFLGIFNTNNPEPNARTVAVVFNTFKNRIDFDKNFIKPYVNENCDFHKYNGEKTDVQITYDSSNNDLRVFLHFTVSQVKCSVSATVHLEKEVDEWVSVGFSATSGLTEDTTETHDVLSWSFSSKFRNKLSNILLNNIL
What is the function of this protein?
Seed storage.  This carbohydrate-binding lectin has toxic effects on bean bruchid pests.
What are the official names of this protein?
Arcelin-5A.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.