PharMolix/UniProtQA huggingface dataset:
Protein: YIDC_ROSDO
Sequence: MDDQNKNLILATALSFIVILVWFVLFPPPEPEMPLTGETSTELTPDAATGSLPSVTSDTAPSVVIEGETRSAALEQAPRVEIATDRVKGSISLLGGRIDDLSLKDYRETQEEDADIVTMLSPVGSPGAYYALYGWAAGAGVDPSQVPGPDTEWQVIDGDILSVDAPVTLQWDNGAGLSFTRIIEIDDNYMFQITQSVANTSDAPVTVAPYGILARHGEPDDLKNFFILHEGVVAMADGELTETNWDDIPEFPVDQREGVPAERIENVLNGWIGFTDHFWMSVLIPDPSASARLTTKYRPRADIYQAETVLPAQTVAPGTSVSATTQLFAGAKEWETIRNYQTDGVDRFIDSIDWGWFFFLTKPIFFLLHYLNAFIGNMGWAIIGLTLIIKAILLPLAYKSYVSMAKMKELQPQMEKLKEEAGDDRQKMQQGMMELYKKEKVNPAAGCLPILLQIPIFFSLYKVIFVTIELRHAPFFGPFQDLSAPDPTSIMNLYGLLPFDGPEPGSIMALIFIGILPLLLGISMWLQQKLNPAPTDPTQQMIFAWMPWVFMFMLGGFASGLVVYWIANNTITFVQQYMIMRSQGYKPDVFGNIKGGFQKKTKPDSK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL6_MYCLE
Sequence: MSRIGKQPIPVPAGVDITIDGQNVLVKGPKGTLDLTVAEPIMLARNDEGAIVVTRPDNERRNRSLHGLSRTLVSNLVTGVTQGYTVSMEIFGVGYRAQLKGSNLEFALGYSHPVVIEAPEGITFAVQSPTKFTITGIDKQKVGQISANIRRLRRPDPYKGKGVRYEGEQIRRKVGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: GUAC_SHIB3
Sequence: MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSDQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYSVEEWQAFINNSSADVLKHVMVSTGTSDADFEKTKQILDLNPALNFVCIDVANGYSEHVVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVMLGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRIFNNL
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Protein: RL20_STRZP
Sequence: MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYYYAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVNDAVAFTALADAAKAKLGK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: BIOB_RALPJ
Sequence: MQSTPLNFVPNAAKAPVTPGQAPDARWSREAIEALFALPFNDLLFQAQQVHRANFDANAVQLSTLLSIKTGGCPEDCSYCPQSARYDTGVEAEKLMPIDAVLEAASRAKQNGASRFCMGAAWRNPKPHQLDAVADMVRGVKAMGLETCVTLGMLKQEQAAQLKEAGLDYYNHNLDTAPEFYGEIITTRTYQDRLDTLEHVRDAGINVCCGGIVGLGESVHERAGLIAELANMEPYPDSVPINNLVKVEGTPLAGNEELDPFDFVRTIAVARITMPKAMVRLSAGREAMDDALQALCFMAGANSIFYGEKLLTTDNPEADADRKLLARLGMRVEVQDHMHHESHVGAQSSHCHIDITPAD
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: HEMH_DEIRA
Sequence: MTTLTNQKPLGVLFMAYGGPENLGEMPGYLADIRAGRVTSQAILDEITNNYRLIGGKSPLPEFTRAQVEATMEQLASTGRPLKAYIGMRHWSPWIEDAVREMLDDGIEQAIAIVLAPQYSSLSVAKYQKKIKAALEMNHGHIDFAYIDNYHTEPGYITALADRVRIGIQEFPEDERDDVHVILSAHSLPVRIIKEGDPYADQLHETARLVAAQAGLTDEQWSWSYQSAGRSPEPWLGPQLDEHLRDLNEQGIKKVVSIAIGFVSDHVEILFDIDIAAQEVAHELGMTLVRPPALNTDPLFIGTLASVIERKAAEVA
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_STRZT
Sequence: MAQDIKNEEVEEVQEEEVVETAEETTPEKSELDLANERADEFENKYLRAHAEMQNIQRRANEERQNLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLGMVQESLIHALKEEGIEEIAADGEFDHNYHMAIQTLPADDEHPVDTIAQVFQKGYKLHDRILRPAMVVVYN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBBA_CHLPN
Sequence: MIETREEVGSANFVSLERAIEDLRAGKFVIVVDEASREDEGDLIIAGEKITVEKMTFLLQHTTGVVCAALSQERLLSLDLPPMVKDNRCRFKTPFTVSVDAAHGVTTGVSAADRTKVVQLLADPKSKPEDFISPGHFFPLASSPGGVLKRAGHTESTVDLMELAGLQPCGVLAELVNEDYSMMRLPQILEFARKHNIAVIPVTSIIAHRMLSDRLVSKISSARLPTIYGDFTIHVYESLLEGMQHLALVKGNVAGKSNVLVRVHSECVTGDILGSKRCDCGEQLSSAMSYIAEKGTGVLVYLRGQEGRGIGLGHKVRAYALQDNGYDTVDANLAMGFPVDSREYGIGAQILVDLKLTTIKLITHNPQKYFGLQGFGLSITERVPLPVRISEDNEQYLRTKQERMGHWLDLPCCNNRVQ
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: NU2M_DICCI
Sequence: MVCLFENLMNMIKYSIYILPLIILIVLSISIKKDVQRVHIIIQSLKLTLIVIMIVIGIEESIYVKLNGHLIKTELIKLFEYLLLGVSYMIIKMFEEGVTEGKKTKITDEGLILIYSSIIGMLISMEAHNLITLFLSLEISSICFYILALNKNSRKGIEGGLKYYIIGGIATTILLLGIVSIYKSTGSLMYTDLLVIVMENTDDYRIQMGIALIVLGLILKLGIAPFHGWLIDVYEGAGMLMTFYLTITQKLVTLMVLINLYQNLIIYTNAIMFTNGLIILILVTLVVGTIGSLRQQKLIRFIAYSAIVNSALLILMLAGSMSEELMVNSVYYLINYIIGLTVLMSLIMGFLRLNDRGTIEDIYQLKNMWVINMFGAIVYILVLMYLAGLPPMTNFISKILILLPYMVLGRVYLTMLAFFLSVGVMIYYMNLVKIIIIDKVQTHEQGVAELEITSKPTKGGRRIVLGVMWLIFSQLYLDEILNVIKVIVALI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AGP1_SACU7
Sequence: MSSSTSPYELKDLKNSSTEVHAAEQENEIEYFETDSNDRPSQQPHLDYEQHNTSAVRRFLDSFKRADQDQEQEAEVAQMNDLTSAISPSSRQAHELEKDETTDKIAPHTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGYIGGKYWHEPGAFNGVHAIDRFKGVVATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIIIVGFLVPYNSDQLLGSSGGGTKASPYVIAIASHGVRVAPHFVNAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKIFSYIDRAGRPLIAMCVSALFAVIAFCAASPKEDQVFTWLLAISGLSQLFTWTAICLSHIRFRRAMKVQGRSLGELGFKSQTGVWGSIYSCIMMILILIGQFWVAIAPIGEGKLDAQAFFENYLAMPILIVLYVGYKMWNKDWKLFIRADKIDLTSHRQIFDEELIKQEDDEYRERLRTGPYWRRVLAFWC
What is the function of this protein?
Broad substrate range permease which transports asparagine and glutamine with intermediate specificity.  Also transports Ala, Cys, Gly, Ser, Thr, Cys, Met, Phe, Tyr, Ile, Leu and Val.  Important for the utilization of amino acids as a nitrogen source (By similarity).
What are the official names of this protein?
General amino acid permease AGP1, Asparagine/glutamine permease.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL3_PSEA8
Sequence: MTIGVVGRKCGMTRIFTEEGVSIPVTVIEVEPNRVTQFKTEETDGYRAVQVTAGERRASRVTKAQAGHFAKANVAAGRGVWEFRLGEEQYAAGDQITVDLFQAGQMVDVTGESKGKGFAGTIKRWNFRGQDNTHGNSVSHRVPGSIGQCQTPGRVFKGKKMSGHLGAERVTVQSLEIVRVDAERNLLLVKGAVPGATGGDVIVRPAAKARG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: MNME_FRATO
Sequence: MYTKDTIVAIATPQGNGGIGIIRISGIDALEIAEKLTKKQLKPRYATFCNVYNDNEIIDHGIVIFFKAPLSYTGEDVVEIQAHGNPFILNLIIKAALNCGARIAKAGEFTERAFLNNKLDLAQAEAVADIINASSEIAAKSAAKSLQGDFSKEINNLLEKLIYLRMYVEASIDFPEEEINFLEDQKIHSSLEEIYKVILAIKNSCKQGVILAEGITLILVGKPNAGKSSLLNALAGKESAIVTSIAGTTRDIVKEHIQINGVPMHIIDTAGLRNSDDIIESEGIKRAIKKIQEADQVLFVTDDYTNSQVKFSDIKEIIPEFYDQIPKDIDITYVHNKIDLLKEVPHNHANHIYISAENNIGIDKLKEHILNKVGYTNQNESIYTARERHVTAINNAFEHIKLAKEQLELGNGELLAEELLIVQEYLNSITGEFSSDDLLGEIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIF4_CHICK
Sequence: MVREEEKGIPVRVVRCRPLVPKETSEGCQMCLSFVPGEPQVIVGSDKAFTYDYVFDPSVEQEEVFNTAVAPLIRGIFKGYNATVLAYGQTGSGKTYSMGGTYTASQEHDPSMGVIPRVIKLLFKEKEQRQDWEFVLKVSYLEIYNEDILDLLCSSRERSSQISIREDPKEGIKIVGLTERNVASARDTVSCLEQGNNCRTVASTAMNSQSSRSHAIFTICIDQKKKNDKNSSFHSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGEENKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVNVDPQAAELNHLKQQVQQLQVLLLQAHGGTLPVSINSMAPSENLQSLMEKNQSLMEENEKLSRGLSEAAGQTAQMLERIIVTEQENEKMNAKLEQLQQHAVCKLDLQKLLETVEDEELKENVEVIRNLQQVLAQFQSESAAAAEAATEMANAEQDAAGEAETGQVTKRSSDDFTTQHALRQAQMSKELVELNKALALKEALAKKMIQNDSQLEPIQSQYQTNIKDLELEVSNLQKEKEELILALSMAKKDVNQAKLSERRRKRLQELEGQINELKKKLNEQAKLLKLKESTERTVSKLNQEIREMKNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERDFQKQASVLRRKTEEAAAANKRLKDALQKQREAADKRKESQNRGMEGVAARVKSWLANEVEVLVSTEEARRHLADLLEDRKILAQELLQLKEKKESGENPPSKLRRRTYSITDLQASEMDLSLSKQIESLETEMELRSAQIADLQQKLLDADNGDRVKQRWDNIATILEAKCALKYLLGELVSSKVQESKLESSLQQSKTNCSDIQKMLIEERNHATEMEAEFQNQLLLQEQQHQQEVLYLLSQFQQKEAPGKGVEDSLSEQEKQMQERLKFQEKELEKMREICEKNQELLQENDVLKQKMLLVQVASGQKLRRDQQVSPESPDSPFDYIPPKPKTRRQTVAKPRAPTPEMNVEELFSDSEESGEEEDAEWVPVKAAKGTKKSATGCFCKGRCGNRQCGCRKQKVGCTAGCSCDSTKCRNRDPGFQDATVCEDQTKDSEGSFKLEDLRDVTAGETFFQPVYSPPTMKVLKDITDQGVFMKKPSTAASLLVRDEESQENQLPFVKKKKRMLSSNTSFFSGCTPIKEEID
What is the function of this protein?
Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity).  Required for mitotic chromosomal positioning and bipolar spindle stabilization.
What are the official names of this protein?
Chromosome-associated kinesin KIF4, Chromokinesin.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytoskeleton.
Protein: EF1G_HORSE
Sequence: MAAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNRTPEFLRKFPAGKVPAFEGDDGFCVFESNAIAYYVSNEELRGSTPEAAAQVVQWVSFADSDIVPPASTWVFPTLGIMHHNKQATENAKEEVRRILGLLDAHLKTRTFLVGERVTLADITVVCTLLWLYKQVLEPSFRQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAESQPKKDTPRKEKGSREEKQKPQAERKEEKKAAAPAPEEEMDECEQALAAEPKAKDPFAHLPKSTFVLDEFKRKYSNEDTLSVALPYFWEHFDKDGWSLWYSEYRFPEELTQTFMSCNLITGMFQRLDKLRKNAFASVILFGTNNSSSISGVWVFRGQELAFPLSPDWQVDYESYTWRKLDPGSEEAQTLVREYFSWEGAFQHVGKAFNQGKIFK
What is the function of this protein?
Probably plays a role in anchoring the complex to other cellular components.
What are the official names of this protein?
Elongation factor 1-gamma, EF-1-gamma, eEF-1B gamma.
Protein: ATPB_AZOPC
Sequence: MPENFGYISQVIGSVVDVSYRYTSGGLPKINDALQITHSNGKVLIVEVQQHIGEDTVRAVAMDSTDGISRGMKAVNLGRPISMPIGNQVKGRLLNVIGETIDGMKCLSYENTKSIHCDPPKFKDLSTSVEVLFTGIKVIDLLAPYLKGGKIGLFGGAGVGKTVLIMELINNIAKKHNGFSVFAGVGERTREGNDLLREMIESGVIRYGKEFEEGMRLGEWDLSKIDYEELKKSQATLVFGQMNEPPGARSSVVLSGLTIAEAFRDQSGSDGHDVLFFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGKMQERITSTKNGSITSIQAVYVPADDLTDPAPATTFTFLDATTVLDRKIFELGIYPAVDPLNSVSRILDPNVLGQEHYDTAQKVKQLLQRYKELQDIIAILGMEELSEEDKLVVNRARRVQRFLSQPFFMAEAFSGIPGVMVSREDTIKGFNMLMNGDVDYLPEQAFLNVGTIEDAIEKGKKLTALT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ASPG2_DROPS
Sequence: MRYLCRAQLLSLLLLPLLKARLSVPAHPIPKIFLPLMISTWNYTDANREAWTVLRQGPRRTRQAVIQGCLHCQNSNSCGRLLGGHSAPDSSGGITLEAALIDGANMDYGAVAGMAGIRNAIGVAHDVLRYTNHSLLVGEAAARFAEAMGHKKEVHSLSTTLDVLLPWLLGKCQPNFWRNVRPLANDSCGTFSPLPQEQHQREMRQEYPIEPGHHDQVGFLALDTEGHLHAASLSSGARFRIPGRVGDAAVPGAGIYADNQVGGALATGDGDVLMRFLPALLAVEALRAGQSPASAAEAVMRRLLRHHTEFNGGLVVVSRGGVYSAACAGLDEFQFVVSGESSGRSMRRVEGIKCLDRHEVVTGGPRGNFYVVPKKIWAAGGEDVLVQRVEKITLNEGVDSREFEEEYVEDKAAEIDVDEGEKAEEVRSLLDESPGDLLLHQLGLAPPFPFRFPFIYF
What are the official names of this protein?
L-asparaginase-like protein GA18140.
What is the protein family that this protein belongs to?
Belongs to the Ntn-hydrolase family.
Protein: AUSW_ASPCI
Sequence: MKHPTVALLGVGMLGCAAALPAGQVANGAQDDPVPAARTAPATAATAPADFGATSDPSIAGTGFPGLAGFPGFPGSGAAQAGPVHAPSTFGPAAGPAGFQGLSGGPGFAFPGFGGGSGFGFTGFGGMSAFPGIPGFGGLQGSAPSQAAAAPSTGDSRSGLPGFPGVSGGSGFGFPSFGGMSASPSLPGFGGLQGSGPSQAAAAPSTGDSGSGLPGSPGFSGGSGFGFPGFGGMSAGGGAPSTMGFPGFPGFTGFPGMTGGFGVPGSAPDQGASTPAQAASFPAAGRAGNAIPSASSAPASNGMGAAASLHNLQARQFVGTTGHGMVPPAXGSGLPGSPGFSGGSGFGFPGFGGMSAGGGAPSTMGFPGFPGFTGFPGMTGGFGVPGSAPDQGASTPAQAASFPAAGRAGNAIPSASSAPASNGMGAAASLHNLQARQFVGTTGHGMVPPAFHYMFGWPPVIPSAAGAMPNLGTGFNADAFGAEFLGGGEMPSPTSTAASVAPTANSVPATGTAEASTSTPVASAATSAVSATSSAE
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
Austinoid biosynthesis cluster protein W.
Protein: RL23_SHIBS
Sequence: MIREERLLKVLRAPHVSEKASTAMEKSNTIVLKVAKDATKAEIKAAVQKLFEVEVEVVNTLVVKGKVKRHGQRIGRRSDWKKAYVTLKEGQNLDFVGGAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: FBPC_NEIMA
Sequence: MTAALHIGHLSKSFQNTPVLNDISLSLDPGEILFIVGASGCGKTTLLRCLAGFEQPDFGEISLSGRTIFSKNTNLPVRERRLGYVVQEGVLFPHLTVYRNTAYGLGNGKGKTAQERQRIEAMLELTGISELAGRYPHELSGGQQQRVALARALAPDPELILLDEPFSALDEQLRRQIREDMIAALRANGKSAVFVSHDREEALQYADRIAVMKQGRILQTASPHELYRQPADLDAALFIGEGIVFPAALNADGTADCGLGRLPVQSGAPAGTRGTLLIRPEQFSLHPHSAPTASIHAVVLKTTPKARHTEISLRVGQTVLTLNLPSAPTLSDGISAVLHLDGPALFFPGNTL
What is the function of this protein?
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Fe(3+) ions import ATP-binding protein FbpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CYSD_ALISL
Sequence: MDAKRLTHLQQLEAESIHIIREVAAEFDNPVMMYSIGKDSSVMLHLARKAFYPGKIPFPLLHVDTDWKFKEMIEFRDKTAKKYGFDLLVHKNPEGIEMGISPFVHGSSKHTDIMKTQGLKQALNQHGFDAAFGGARRDEEKSRAKERVYSFRDKNHTWDPKNQRPELWNTYNGQVNKGESIRVFPLSNWTELDIWQYIYLESIDIVPLYLAEKRPVVDRDGMLIMVDDERMELKEGEKIEYKDIRFRTLGCYPLTGAVESKANTLPEIIEEMLVATSSERQGRAIDHDSSGSMEQKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: PUR7_LACLA
Sequence: MEKEKLLYEGKAKKLYFTDDSEVLWVEYCDQATALNGARKEQITGKGALNNQITSLIFEKLNAEGLETHFIEKLSKTEQLNRKVSIIPLEVVLRNVVAGSFAKRFGLEEGIVLQEPIVEFYYKDDALDDPFINDEHVRFLNIATYSEIEFLKSETRKINEILKKIWAEIGLTLVDFKLEFGRLADGRIILADEISPDTSRLWDANGQHMDKDVFRRNIGDLVETYTEVLNLLENAK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: DTD_VIBCM
Sequence: MIALIQRVSEAAVRVDGEVVGAIDKGLLVLLGVEREDDEAKAKRLVERVTSYRVFEDSEGKMNLSVKDVGGSVLVVSQFTLPADTKKGTRAGFSRGAAPQEAERLYDYFSDLCAQILPTERGRFAADMKVSLINDGPVTFWLQA
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBID_ALIF1
Sequence: MQYKDLRDFIGHLEDIGQLKRISHPIDPHYEMTEISDRTLRAGGPALLFENPIGYDIPVLTNLFGTPERVAIGMGRKDVLELREVGKLLAYLKEPEPPKGFKDALDKLPVFKQVLNMPTKNIRKAACQQIVWQGDDVDLDKVPVMSCWADDVAPLLTWGLTITKGPHKKRQNLGIYRQQKLSKNKVIMRWLAHRGGALDLRDWMETHPGEPFPVSVAFGADPATILGAVTPVPDTLSEYAFAGLLRGSRTEITKSISNDLEVPASAEIVLEGYIDPTEFADEGPYGDHTGYYNEVEKHHVFTVTHITMRKEPIYHSTYTGRPPDEPAVLGVALNEVFVPILQKQFPEIIDFYLPPEGCSYRMAVVTMKKQYPGHAKRVMMGVWSFLRQFMYTKFVLVCDEEVNARDWSQVTAAMSQHMDPARDSLMIENTPIDSLDFASPVVGLGSKMGLDITKKWEVELALSPNVECSLTSSEQIEGCIAEITKMCPEIIEIHLQNDNANMVVVSINKQAAGNAKKIMDAIWAQFEENKFVIVCDDDVNVSDWNDIIWAVTTRMDPARDTLFLQSVGETSKMGLDATNKWEGECLREWGTPIKKDPEVVAKIDSIWDELGIFK
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.