PharMolix/UniProtQA huggingface dataset:
Protein: IF2_CHLCH
Sequence: MTLGESEKRYRISDIARELQLSPQEVLQFVKQQGVKVASTSSMVNEEVHGLIINQFSAEKKMVDETLKIRAEKEKRLTRLEEQSRKTLEKEQHLMEAISPTVRASKSSAKGSESAPKSEPKKSKQAVPAAAMVDDVPAAVVQQVVAEPEVVEPTPVVEVEAPALEPAIISEHVVDAEPIENAVTVAPVEVVVNEPIETVESVEPEFVVAEVTPLEPIAQSTIEIVAEGESVEVAEALHVAEPVVAIPPITETAELSDSTVEPIEPIASVPSTAPAPPARREPTVNENLVSFAAPQMMGGLTVVGTLDMHTGRGRKNRKKNFREQADALKGEFEVKAAAPVASENKTEAGVAKKSKPAAEVKPKPATTTAADDAKKAKKGKKKKKPDVDEKVISANIQKTISGIDDRSGTGSRQKFRKMRRSEREREQEEGAAQRELEQSIVRVTEFASPHELAELMGITAKDIIQKCFGLGKFVTINQRLDRESIELIALEFGFEAEFISEVEATAVETEADAEEDLQTRPPVVTIMGHVDHGKTSLLDYIRKSRVVAGESGGITQHIGAYEVTVDGDRKITFLDTPGHEAFTAMRARGAQVTDIVILVVAADDNVMPQTIEAINHAKAAGVPIVVALNKIDKSEANPDKIKTQLSEAGVLIEEWGGVYQCQEISAKKGIGIVELMEKVLTEAELRELKGNYSREVLASGVIVESELDKGKGVVSTVLVQRGVLKVGDPFVAGNSLGKVRALMDERGKRILLAFPSQPVRVLGFEDLPQSGDVLTVMASERDARDLAQKRQIIRREHDFRRSTRVKLDSIARQIREGVMKELNVIIKADTDGSIQALADGLMKIQNDEVKVQLIHQGVGQITETDVLLAAASDAIIIGFRVRPNVNAKKLAEKEDLDIRFYSVIYHVLEDVETALEGMLSPELHEESLGSIEIRQIFRVPKVGNVGGCYVLEGKVPRDAKVRLLRDGVQIYEGQLAALKRFKDDVKEVDSGYECGLSLKNYDDIKVGDVVEAYRIVEKKRKL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPB_STAAC
Sequence: MDINKMTYAVQSALQQAVELSQQHKLQNIEIEAILSAALNESESLYKSILERANIEVDQLNKAYEDKLNTYASVEGDNIQYGQYISQQANQLITKAESYMKEYEDEYISMEHILRSAMDIDQTTKHYINNKVEVIKEIIKKVRGGNHVTSQNPEVNYEALAKYGRDLVEEVRQGKMDPVIGRDEEIRNTIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVKKDVPESLLDKTVFELDLSALVAGAKYRGEFEERLKAVLKEVKESDGRIILFIDEIHMLVGAGKTDGAMDAGNMLKPMLARGELHCIGATTLNEYREYIEKDSALERRFQKVAVSEPDVEDTISILRGLKERYEVYHGVRIQDRALVAAAELSDRYITDRFLPDKAIDLVDQACATIRTEMGSNPTELDQVNRRVMQLEIEESALKNESDNASKQRLQELQEELANEKEKQAALQSRVESEKEKIANLQEKRAQLDESRQALEDAQTNNNLEKAAELQYGTIPQLEKELRELEDNFQDEQGEDTDRMIREVVTDEEIGDIVSQWTGIPVSKLVETEREKLLHLSDILHKRVVGQDKAVDLVSDAVVRARAGIKDPNRPIGSFLFLGPTGVGKTELAKSLAASLFDSEKHMIRIDMSEYMEKHAVSRLIGAPPGYIGHDEGGQLTEAVRRNPYSVILLDEVEKAHTDVFNVLLQILDEGRLTDSKGRSVDFKNTIIIMTSNIGSQVLLENVKETGEITESTEKAVMTSLNAYFKPEILNRMDDIVLFKPLSIDDMSMIVDKILTQLNIRLLEQRISIEVSDDAKAWLGQEAYEPQYGARPLKRFVQRQIETPLARMMIKEGFPEGTTIKVNLNSDNNLTFNVEKIHE
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG137_VACCC
Sequence: MTTVPVTDIQNDLITEFSEDNYPSNKNYEITLRQMSILTHVNNVVDREHNAAVVSSPEEISSQLNEDLFPDDDSPATIIERVQPHTTIIDDTPPPTFRRELLISEQRQQREKRFNITVSKNAEAIMESRSMISSMPTQTPSLGVVYDKDKRIQMLEDEVVNLRNQRSNTKSSDNLDNFTRILFGKTPYKSTEVNKRIAIVNYANLNGSPLSVEDLDVCSEDEIDRIYKTIKQYHESRKRKIIVTNVIIIVINIIEQALLKLGFEEIKGLSTDITSEIIDVEIGDDCDAVASKLGIGNSPVLNIVLFILKIFVKRIKII
What is the function of this protein?
Required for viral crescent formation early during virus morphogenesis.
What are the official names of this protein?
Protein OPG137.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG137 family.
Protein: RUVC_RHILO
Sequence: MGDAIRIIGIDPGLRRTGWGIVESLGNSLRFVASGTVRSEDKAALATRLCQLHDGLAEVLHAAMPHEAAVEQTFVNKDAVATLKLGQARGIAMLVPARAGLVVAEYAPNAVKKAVIGVGHGDKKQIHMMVKVLLPKATFDTEHAADALAIAICHAHHRQSAAYRMALAG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: HBB_PAGMA
Sequence: MVEWTDAERSAIKTLWGKINVAEIGPQALTRLMIVYPWTQRHFSSFGNISTNAAILGNEKVAEHGRTVMGGLDRAVQNLDDIKNAYTLLSQKHSEIIHVDPDNFRLLAECFSICVGIKLGPKVFNANVQEAWQKFLAVVVNALGRQYH
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: Y1370_STRGC
Sequence: MSNIYDLANELNRTFRELPEYKAVLESKAAIDADSEAKSLFDDYIAFQGKIQQLMQTGQMPTPELQEEMKSFGEKIQANAIVTEFFTKQQQLSVYLSDIERIVFEPIQDLMK
What are the official names of this protein?
UPF0342 protein SGO_1370.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: LDHA_CHIRA
Sequence: MSTKEKLISHVMKEEPVGSRNKVTVVGVGMVGMASAISILLKDLCDELAMVDVMEDKLKGEVMDLQHGSLFLKTKIVGDKDYSVTANSKVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCILMVVSNPVDILTYVAWKLSGFPRHRVIGSGTNLDSARFRHLIGEKLHLHPSSCHAWIVGEHGDSSVPVWSGVNVAGVSLQGLNPQMGTEGDGENWKAIHKEVVDGAYEVIKLKGYTSWAIGMSVADLVESIIKNMHKVHPVSTLVQGMHGVKDEVFLSVPCVLGNSGLTDVIHMTLKAEEEKQLQKSAETLWGVQKELTL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYL2_RAT
Sequence: MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).
What are the official names of this protein?
Dynein light chain 2, cytoplasmic, Dynein light chain LC8-type 2.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL34_PSELT
Sequence: MKRTYQPNRRKRKRTHGFLVRSRTPSGRRVLARRRAKGRWKIAV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: TTCA_ACISJ
Sequence: MNTANNTLPTAADWAGEDAAPDAADTRKIERESHKLEKRLCREVGRAITDFNMIEEGDKIMVCMSGGKDSYTLLDILRKLQKRAPVKFDIVAVNLDQKQPGFPEHVLPDYFKSIGVQYHIENQDTYSVVKRVVPEGKTTCSLCSRLRRAILYKVADDLGCTKLALGHHRDDIVATLMLNMFYGGRMKGMPPKLVSDDGKHVVIRPLCYVPEKDTARWAQYQQFPIIPCNLCGSQDGLQRVAVNEMLREWDKKFPGRIESMLRAMGHVVTTHLMDPHLHDFKNAKATGIADPNGDMAFDHEEFPVAPALPGLQVVQLG
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_ONYPE
Sequence: MQRNFRKTFVGKVVSDKMDKTITVIVDIYKKDPLYGKRVKQSKKFHVHDENQEAKPGDLVNFMETRPLSKTKRFRLFKILSHAKSAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RMUC_PSEAE
Sequence: MLGERLATAQLAQDGLNAQLETSREAYQQLGERHARFAGEVAALRREAELMGEERQRASQAEARWASERQGREEELRRLASERAALAAELREQQESHQQRLTDLQSARDELRAQFAELAGKIFDEREQRFAETSQQRLGQMLDPLKERIQAFEKRVEESYQQEARERFSLSKELERLQQLNLRLGEEATNLTRALKGQKTQGNWGELVLERVLEHAGLEKGREYETQVSLKGAEGERFQPDVLIRLPGDKQVVVDAKVSLTAYQQYIAADDDLLRQQALKQHVTSLRNHVKGLSGKDYRRLEGLHSLDFVLLFMPIEAAFSTALQAEPNLFQDAFAQNIVIVSPTTLLATLRVIDSLWRQERQNQNAREIAERAGSLYDKFVLFVQDLDEVGSRLQQLDKAYAAARNKLTEGRGNLISRSEQLKLLGARASKSLPTDWLDRALVAPVEEAGEE
What is the function of this protein?
Involved in DNA recombination.
What are the official names of this protein?
DNA recombination protein RmuC homolog.
What is the protein family that this protein belongs to?
Belongs to the RmuC family.
Protein: NQRF_IDILO
Sequence: MQEIYLGVGMFTIIVLVLVAIIMFAKSKLVPQGDVEILINDDEDKKIVTQPGTKLLGALANAGIFVSSACGGGGSCGQCRVTVKEGGGDILPTELDHITKREAREGCRLSCQVNVKQDMEIELPEEVFGIRKWDCTVKSNDNVATFIKEFIVQLPEGEEVPFRAGGFIQIEAPPHHVKYKDFDISEEYHGDWDRFGFFDVESKVDEEVVRAYSMANYPEEKGIIMLNVRIATPPPNDLSLPAGKMSSYIFSLKPGDKVTISGPFGEFFAKDTDAEMVFIGGGAGMAPMRSHLFDQMRRIKTDRKVSFWYGARSKKEMFYVEDFDMLAEENENFDWHVALSDPQPEDNWEGDTGFIHNVLYERYLKDHDAPEDCEFYMCGPPVMNAAVINLLKDLGVEDENIMLDDFGG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit F, Na(+)-NQR subunit F, Na(+)-translocating NQR subunit F, NQR complex subunit F, NQR-1 subunit F.
What is the protein family that this protein belongs to?
Belongs to the NqrF family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RLMN_SULNB
Sequence: MPTHKKIIQDLTKEELAEKIKPAFRSKQIYDWIYHKYAASFEEMKNLPKAMREELDAEYTLAPLKTVTVQDSMDGSRKYLFELHDGHTVEAVLLLMRDKEYHEDGSVKHQERYTVCISSQVGCKVGCAFCLTAKGGFMRNLTAGEIVEQLRMIKKDNDIAANRRVNIVFMGMGEPLDNLEAVAKSVKIFAEEEGMAIAPHRQTISTSGLSSKIEKLGKMELGVNLAISLHAVDDELRQQLMPINKAYNIESIITAVKNFPVNDRKRVMFEYLVIKDVNDDISAAKKLLSLLDGIKAKVNLIYFNPYGGTEFKRPSEADMKKFQEYLTKRGLHCTIRESKGLDISAACGQLREQELEGEI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBB_FRAPO
Sequence: VHWTAEEKQLITGLWGKVNVAECGAEALARLLIVYPWTQRFFASFGNLSSPTAILGNPMVRAHGKKVLTSFGDAVKNLDNIKNTFSQLSELHCDKLHVDPENFRLLGDILIIVLAAHFSKDFTPDCQAAWQKLVRVVAHALARKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: MIAE_SALTY
Sequence: MTVRQRLLSYFFNRLRMNYPQILSPVLNFLHCPTPQAWIVQARDPQNLPLLLTDHLICELKAAQTALLLVRKYVADKSGADALLSWLQPYEAFAFRQGPEPDFVALHKQISKSAMPQTDDPWGRQLIDRMVLLIKEELHHFWQVREVMQARNIPYVKITASRYAKGMLKAVRTHEPLTLIDKLICGAYIEARSCERFAALAPWLDEDLQTFYLSLLRSEARHYQDYLALAQQISAEDISARVRYFGEVEADLILSPDREFRFHSGVPAAG
What is the function of this protein?
Involved in specific tRNA modification.  Catalyzes the oxygen-dependent hydroxylation of 2-methylthio-N-6-isopentenyl adenosine (ms2i6A) to produce 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A) at position 37 in tRNAs (PubMed:8253666, PubMed:17679698, PubMed:23906247).  Can also use N6-(dimethylallyl)adenosine (i6A) as substrate, with lower efficiency (PubMed:23906247, PubMed:25453905).  The presence of the hydroxyl group on the tRNA may regulate the ability of S. typhimurium to grow on the citric acid cycle (CAC) intermediates succinate, fumarate and malate (PubMed:9620964).
What are the official names of this protein?
tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase, 2-methylthio-N6-isopentenyladenosine(37)-tRNA monooxygenase, tRNA-(ms[2]io[6]A37)-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the MiaE family.
Protein: QUEF_NITOC
Sequence: MPSQPNRELETFANPLPERDYTIRIRIPEFTCLCPKTGQPDFATLQLEYVPDQACVELKSLKLYIWSYRDQGAFHEAVTNQILDDLTAVCKPRFMRLTAEFNVRGGIYTTVAAEYRQPGWDAPKIVRLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMLA_MYCS2
Sequence: MRGIILAGGSGTRLHPLTIGVSKQLLPVYDKPLVYYPLSTLIMAGIRDILVITTPADAPAFRRLLGDGSDFGVNLSYAAQNEPEGLAQAFLIGADHIGNDTVALALGDNIFYGPGLGTSLRRFEHVSGGAIFAYWVANPSAYGVVEFDADGKAVSLEEKPKTPKSHYAVPGLYFYDNTVIDIARSLKKSARGEYEITEVNQIYLNRGQLSVEVLARGTAWLDTGTFDSLLDASDFVRTIELRQGLKVGAPEEIAWRAGFIDDDQLATRAKELLKSGYGHYLLQLLDRE
What is the function of this protein?
Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.  Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.
What are the official names of this protein?
Glucose-1-phosphate thymidylyltransferase, dTDP-glucose pyrophosphorylase, dTDP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the glucose-1-phosphate thymidylyltransferase family.
Protein: COBQ_GLOC7
Sequence: MKAIMVVGTTSHAGKSFLTTALCRILARRGWHVTPFKGQNMALNSYVTPTGGEMGFAQAVQAWAAGTAPRVEMNPILLKPQGNMTSQVILMGKVAGQTTASDYYEQYFKPGWEAIASALKRLAFEYDLVICEGAGSPAEINLKHRDLTNMRVAQHLGATTLLVVDIDRGGAFAHVVGTLALLDPEERALIKGIIINKFRGQRSLLDSGIKWLEDYTGIPVLGVIPWSEILFPAEDSLDLFERKTKPNGEININVIRLPRISNFTDFDALESEPTVSLNYLDLSQELGYPDAVIIPGSKTTIQDLSALHTSGMAEKLEQYANAGGIVLGICGGFQMLGRRVLDPNQIEGKQEEFAGLNLLPIETTILPDKITTQRQVFSNHPQSGLPVTGYEIHQGITRLADGVKNLENVGCQALFNDEKLGIVTHSQLVWGCYLHGLFDNGAWRRAWLNFLRHRRGLSALPTGIPNYREQREATLNSVADLVEANVNLSPILSQL
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: M2_I82A7
Sequence: MSLLTEVETPTRNGWECKCSDSSDPLVIAASIIGILHLILWILDRLFFKCIYRLLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: CCNC_RAT
Sequence: MAGNFWQSSHYLQWILDKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTSLIAATTSVLKTRFSYASPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDVLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
What are the official names of this protein?
Cyclin-C.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HAND1_BOVIN
Sequence: MNLVGSYAHHHHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAAASYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQAGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPGEKRIKGRTGWPQQVWALELNQ
What is the function of this protein?
Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity).  Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity).  Acts as a transcriptional repressor of SOX15 (By similarity).  In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).
What are the official names of this protein?
Heart- and neural crest derivatives-expressed protein 1.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity).
Protein: UBIE_BRASB
Sequence: MDQTDQTTHFGFRDVPLGEKQTLVNDVFHSVAQRYDLMNDLMSAGLHRVWKDIMINTLNPPKSDAPFALLDVAGGTGDISFRAARKAGAGFHATVCDINGDMLEVGRQRALKQYLEDKVSFVEGNAEKLAFPDRSFDAYTIAFGIRNVPQIELALAEAYRVLKHGGRFLCLEFSTVEVPGLDKLYDLFSFNVIPQLGRAVTGDAESYRYLVESIRQFPRPNAFAEMISAAGFSRVSWQTLSGGIVALHSGWRL
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RF1_PSEAE
Sequence: MKASLLKKLDVLSDRYEELTALLGDAEVISDQTRFRAYSREYAEVEPVILAFRDYRKVQADLEGAQALLKDSDPELRDLAEEEVAEARGRLAALGDSLQRMLLPKDPNDSRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERQGWRIETLSENEGEHGGYKEVIARVEGDNVYAKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQAAIEINPADLRVDTYRSSGAGGQHVNKTDSAVRITHIPSGIVVECQEERSQHKNRAKAMAWLAAKLNDQQQAAAQQAIASTRKLLVGSGDRSERIRTYNFPQGRVTDHRINLTLYSLGEVMEGAVEQVIEPLLQEYQADQLAALGD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSD_SALPB
Sequence: MLNQLENLTERVGGSNKLVDRWLDVRKHLLVAYYNLVGIKPGKESYMRLNEKALDNFCQSLVDYLSAGHFSIYERILHKLEGNGQLLHAAKIWPLLEDNTQRIMDYYDTSLETAIDHDNCLEFQQALSDIGEALEARFVLEDKLIMLVFDAMHDGARVKRPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCSA_ACAM1
Sequence: MDLVLLQNKLDNLSFAVLFVTMLVYWGGLAFPNIPFFPTLGTAGMAIANLCMACLLGARWMEGGYFPISNLYESLFFLAWGVTTIHLLAEWLSRSRLVGAATAPVAMGIAAFAALSLPDEMQSSAPLVPALKSNWLMMHVSVMMLSYSALIVGSLLAIAFLIVTFGQPVELKGSSIGTGSFRKREPQAPAASTASNLDEGLSMGSAQATAVLTPVSTPQAPSFSLNRMSLAESLDNLSYRMIGLGFPLLTVGIIAGAVWANEAWGAPWSWDPKETWALITWLVFAAYLHARITRGWQGRRPAYLATGGFFVVWVCYLGVNLLGKGLHSYGWFF
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.