PharMolix/UniProtQA huggingface dataset:
Protein: NANE_STAHJ
Sequence: MLPNGLIVSCQALPDEPLHSSFIMSKMALAAYQGGAVGIRANTKEDILAIREEVSLPVIGIVKRDYEGSNVFITATSKEVDELIESGCEVIALDATTQTRPKESLEELVHYIREKAPHVEIMADISTVEEAINADHLNFDYIGTTLRGYTSYTKGHILFENDFEFLKEVLEKVNAKVIAEGNVITPEMYKKVSDLGVHCTVVGGAITRPKQITERFIEAVQQK
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: GPN2_DANRE
Sequence: MMSSDPPSLRFGQVVIGPPGSGKTTYCRGMQEFLSRLGRKVVIVNLDPANEGLPYPCAVDIAELVTLDDVMDGLKLGPNGGLIYSMEYLEANLDWLENKLKLHHDCYFLFDCPGQVELYTHHNSVKNIFAQLSKWNFRLTAVHLVDSHYCADPAKFISVLCTSLSTMLHVELPHVNVLSKMDLIEQYGKLAFNLDFYTEVLDLSYLVEHLSADPFFRNFNHLNVKLAEVIQDYSLVSFVPLNVQDKESMMQVLRTVDKANGYCFGDLEERNLQAMMSAAVGADFQFSTTLGVQEKYLDATKNHVEDEVMDL
What is the function of this protein?
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII).  May act at an RNAP assembly step prior to nuclear import.
What are the official names of this protein?
GPN-loop GTPase 2, ATP-binding domain 1 family member B.
What is the protein family that this protein belongs to?
Belongs to the GPN-loop GTPase family.
Protein: DCTA_PSEU2
Sequence: MTTRQPIYKSLYFQVIVAIVIGILIGHFYPDTGKALKPLGDGFIKLIKMVIAPIIFCTVVSGIAGMQSMKSVGKTGGYALLYFEIVSTIALLIGLIVVNVVQPGAGMNIDVSTLDASKIAAYVTAGQDQSIVGFILNVIPNTIVGAFANGDILQVLMFSVIFGFALHRLGAYGKPVLDFIDRFAHVMFNIINMIMKLAPLGAFGAMAFTIGAYGVSSLVQLGQLMICFYITCALFVVFVLGAIARAHGFSIFKLIRYIREELLIVLGTSSSESALPRMLIKMERLGAKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTHMDITHQITLLLVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNAVATVVVAKWVGELDTDKLQSELASGGSAILETRPEDDLGVAEGPTPGAAVNTTKTV
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSLO_LACLA
Sequence: MDKIIKSISKNGHFRAFALDSTLTVKEAQERHQTWPTSTVALGRTLIAGQILGANEKGDTKITVKVLGDGAMGPIIAVADSRGHVKGYVKNRKLDYKKASTGEVLVAPFVGNGFLVVVKDMGLKQPYSGQVDLITGEIGEDLAWYFLSSEQTPSSVGVNVLLNEDSDTVKIAGGFMLQALPDATDEEITEIEHNIKSMPSIATMLTSEEPLKTMLDNIYGDMEYKNLGEFPLEFKCDCSKERFLEGIKSLGREPIEEMIAEDHGAEIICQFCENKYEYSEDELKALLK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_MACCJ
Sequence: MFMGEFQHQLDAKGRMIVPAKFREELTEHFVITRGLDKCLFGYTLTEWAAIEEKLKALPLTRRDARKFMRMFFSGAVEVEMDKQGRINIPKHLMEYAGLSKEATVIGVSSRIEIWDRKLWSDFYEETEEEFETIAEELIDFDF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: NADK_STRPM
Sequence: MMTQMNYTGKVKRVAIIANGKYQSKRVASKLFSVFKDDPDFYLSKKNPDIVISIGGDGMLLSAFHMYEKELDKVRFVGIHTGHLGFYTDYRDFEVDKLIDNLRKDKGEQISYPILKVAITLDDGRVVKARALNEATVKRIEKTMVADVIINHVKFESFRGDGISVSTPTGSTAYNKSLGGAVLHPTIEALQLTEISSLNNRVFRTLGSSIIIPKKDKIELVPKRLGIYTISIDNKTYQLKNVTKVEYFIDDEKIHFVSSPSHTSFWKRVKDAFIGEIDS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLAH_ECO5E
Sequence: MNALTAVQNNAVDSDQDYSGFTLIPSAQSPRLLELTFTEQTTKQFLEQVAEWPVQALEYKSFLRFRVGKILDDLCANQLQPLLLKTLLNRAEGALLINAVGVDDVKQADEMVKLATAVAHLIGRSNFDAMSGQYYARFVVKNVDNSDSYLRQPHRVMELHNDGTYVEEITDYVLMMKIDEQNMQGGNSLLLHLDDWEHLDHYFRHPMARRPMRFAAPPSKNVSKDVFHPVFDVDQQGRPVMRYIDQFVQPKDFEEGVWLSELSDAIEISKGILSVPVPVGKFLLINNLFWLHGRDRFTPHPDLRRELMRQRGYFAYATHHYQTHQ
What is the function of this protein?
Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG).  Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Glutarate 2-hydroxylase, G-2-H.
What is the protein family that this protein belongs to?
Belongs to the glutarate hydroxylase family.
Protein: PLM_RAT
Sequence: MASPGHILIVCVCLLSMASAEAPQEPDPFTYDYHTLRIGGLTIAGILFILGILIILSKRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
What is the function of this protein?
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (By similarity).  Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (PubMed:17283221).  Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity).  Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (By similarity).
What are the official names of this protein?
Phospholemman, FXYD domain-containing ion transport regulator 1, Sodium/potassium-transporting ATPase subunit FXYD1.
What is the protein family that this protein belongs to?
Belongs to the FXYD family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Membrane, caveola. Cell membrane, sarcolemma, T-tubule. Note=Detected in the apical cell membrane in brain (PubMed:12657675). In myocytes, localizes to sarcolemma, t-tubules and intercalated disks (PubMed:23532852).
Protein: KI3L1_HUMAN
Sequence: MSLMVVSMACVGLFLVQRAGPHMGGQDKPFLSAWPSAVVPRGGHVTLRCHYRHRFNNFMLYKEDRIHIPIFHGRIFQESFNMSPVTTAHAGNYTCRGSHPHSPTGWSAPSNPVVIMVTGNHRKPSLLAHPGPLVKSGERVILQCWSDIMFEHFFLHKEGISKDPSRLVGQIHDGVSKANFSIGPMMLALAGTYRCYGSVTHTPYQLSAPSDPLDIVVTGPYEKPSLSAQPGPKVQAGESVTLSCSSRSSYDMYHLSREGGAHERRLPAVRKVNRTFQADFPLGPATHGGTYRCFGSFRHSPYEWSDPSDPLLVSVTGNPSSSWPSPTEPSSKSGNPRHLHILIGTSVVIILFILLLFFLLHLWCSNKKNAAVMDQEPAGNRTANSEDSDEQDPEEVTYAQLDHCVFTQRKITRPSQRPKTPPTDTILYTELPNAKPRSKVVSCP
What is the function of this protein?
Receptor on natural killer (NK) cells for HLA Bw4 allele.  Inhibits the activity of NK cells thus preventing cell lysis.
What are the official names of this protein?
Killer cell immunoglobulin-like receptor 3DL1, CD158 antigen-like family member E, HLA-BW4-specific inhibitory NK cell receptor, Natural killer-associated transcript 3, NKAT-3, p70 natural killer cell receptor clones CL-2/CL-11, p70 NK receptor CL-2/CL-11.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ADH_DROBO
Sequence: MAIANKNIIFVAGLGGIGLDTSREIVKSGPKNLVILDRIDNPTAIAELKAINPKVTVTFYPYDVTVPLAETTKLLKTIFAQLKTVDLLINGAGILDDHQIERTIAVNFTGTVNTTTAIMEFWDKRKGGPGGVVANICSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITRTPLVHRFNSWLDVEPRVGELLLEHPTQTTLECAQNFVKAIEANKNGAIWQLDLGQLIAVEWTKHWDSHI
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: UPPP_PSEA8
Sequence: MEWWTAFQAFILGVVEGLTEFLPISSTGHQIIVADLIGFGGERAKAFNIIIQLAAILAVVWEFRGKIFQVVRDLPSQRQAQRFTANLLIAFFPAVVLGVLFADLIHEWLFNPITVALALVVGGVVMLWAERRKHVIHAEHVDDMTWKDALKIGCAQCLAMVPGTSRSGATIIGGLLFGLSRKAATEFSFFLAMPTMVGAAVYSGYKYRDLFRPEDLPVFAVGFVTSFVFAMLAVRALLKFIGNHSYAAFAWYRIAFGLLILATWQFHLIDWSTAGEM
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y06F_BPT4
Sequence: MAQLSAGFGYEYYTAPRRVSVAPKKIQSLDDFQEVVRNAFQDYARYLKEDSQDCLEEDEIAYYTQRLEQLKNLHEVRAEVSKSMNKLIRFKE
What are the official names of this protein?
Uncharacterized 10.9 kDa protein in regB-denV intergenic region.
Protein: T3MH_HAEIN
Sequence: MKTDIQTELTQALLSHEKVWANEEKTILAKNILLDLVEKTDPTIIGLLLGNDDLKRHFFVEVNGVLVFKLQDFRFFLDKHSINNSYTKYANRIGLTDGNRFLKDSSDIVLDFPFKDCVLNGGQSTEEGEEIYFKRNNSQSVSQSVSQSVSQSVSQSVSQSVSQSVSQSVSQSVSQSVSQLYTKLTRKRQEIFFNQTLAFDEIDRLFDAKAFSKFSRYTADGKQAVGEIKRHSDGTPAENLIIKGNNLIALHSLAKQFKGKVKLIYIDPPYNTGNDGFKYNDKFNHSTWLTFMKNRLEIAKTLLADDGVIFVQCDDIEQAYLKILMDDIFDRDNFLNIVTVKTKIGGVSGSSEGKSLKDSTEFINVFSKNRERLFLNPVYQKTEVNEFIKNYEDSGKSWKYTQVLIDLGEKILLEEKDGFKYYHYPNAQMTSIVKFSQDQNLSKEIIYTEYSHKVYRTTNAQSSIRSKIIEDLYSIKNGIVSIEYIPQKGKNAGNLIEVFYNASNKDMFMFLSDMLIKEKNKYFYLQKVNTLWDDIQYNNLNKEGGYIDFKNGKKPEALLRRIIDMTTKEGDIVLDYHLGSGTTAAVAHKMNRQYIGIEQMDYIETLAVERLKKVIDGEQGGISKAVNWQGGGEFVYAELAPFNETAKQQILACEDSDDIKTLFEDLCERYFLKYNVSVKEFSQIIEEPEFQSLPLDEQKQMVLEMLDLNQMYVSLSEMDDEQFAGCLNDDDKALSRAFYQAEKKDGE
What is the function of this protein?
A beta subtype methylase that binds the system-specific DNA recognition site 5'-CGAAT-3' and methylates A-4 (of only 1 strand).  DNA restriction requires both the Res and Mod subunits.
What are the official names of this protein?
Probable type III restriction-modification enzyme HindVI Mod subunit, M.HindVI, Probable HindVI methyltransferase, Probable type III methyltransferase M.HindVI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: RZOQ_ECOLI
Sequence: MRNRNLLKFLPGLLICLIVLTSCVPKQKNMPYALTQRSIPQILPLPSEAKQPKPPKECSPTCSEILQQKLSFMLKLLTNATSQE
What are the official names of this protein?
Putative lipoprotein RzoQ.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: VF146_ASFWA
Sequence: MGGTADFVLSITIVLVILIIIAFIWYNFTGWSPFKYSKGNIVTFKTPDESSIAYMRFRNCIFTFTDPKGSLHSIDVTEVLNNMAKGFRDAQNPPSSFTLGGHCQAPLNAFSFVLPGVNDRATVVTADDAKKWENCDATLTGLQRII
What are the official names of this protein?
Uncharacterized protein E146L, pE146L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus E146L family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein. Virion.
Protein: C2_ECTVM
Sequence: MESVIFSINGEIIQVNKEIITASPYNLFKRIQDHHLKDEAIILNGINYHAFESLLDYMRWKKINITINNVEMILVAAIIIDVPPVVDLCVKTMIHNINSTNCIRMFNFSKRYGIKKLYNASMSEIINNITAVTSDPEFGKLSKDELTTILSHENVNVNHEDVTAIILLKWIHKNPNDVDIINILHPKFMTNAMRNAIALLGLTISKSTKPVTRNGIKHNIVVIKNSDYISTITHYSPRTEYWTIVGNTDRQFYNANVLHNCLYIIGGMINNRHVYSVSRVDLKTKKWKTVTNMSSLKSEVSTCVNNGKLYVIGGLEFSISTAVAEYLKHGASKWIRLPNLITPRYSGASVFVNDDIYVMGGVYTTYEKYVVLNDVECFTKNRWIKKSPMPRHHSIVYAVEYDGDIYAITGITHETRNYLYKYIVNEDKWIELYMYFNHVGKMFVCSCGDYILIIADAKYEYYPKSNTWNLLDTSTRNIEYYDMFTKDETPKCNVTHKSLPSFLSNCEKKFLQ
What are the official names of this protein?
Kelch repeat protein C2.
What is the protein family that this protein belongs to?
Belongs to the poxviruses Kelch family.
Protein: ALPK2_DANRE
Sequence: MTAKRVDMAAPDNLLFLDSDAVNSSPASVPIEQNEPTHVLDNQTDDSLRSMPDPHTNTALESTGLMPVPCQDETLETHSQHNEGENESSLVSTQHMDHTRLTEMTINDEKSNNWDFDISGVKENDNSTNLNPDLIHHAGTDSVMERNLNDKQTDLNHKDETFGSLMSSEVLLLKENRQQEMSQDTNLHQCSSSESTGIEYSQTANDAISDAMNSEQSPDQPFSIASNDTDKTTSECSVQTCWDTVESAATSKTQPELHDDVKDVMCESFTTSQTLNIDYLSTDISVCLADLPETDSLNILTPASTLLGILGKNNNVLKTADVPINDSEMVQSINKDLASPNADISKTVFTQMDQNLLHVTDHNVKVLESNRADTVVDQYVFSENIGQEVSQASSHDEDLNSSVQSHDQQLSTANSEIEETSSEFHTQTCQDIHEGVIIAEEAMNGHNTLPEMHDIADVTTSQTPIMKDPMIDEPSYLPDLHKADTPNVITTASTLSDTLETDDSIFETADVSVSDCELIQTVTLKTVTTYETLLMMHDVGEDLTCCDFTTSAIEEPETSHPLSLDDLHESNTPNIPPHASALLDSLGMNKNFLETADVPVSDCEVIQTVTFETVTTYETFPVMHDIAEDLTCCDFTTSETPKIEEPETSHSLSLDDLNEANTPNILPHASALLESLGMNNNFLEAADMPVSDREIIHPVNKDLDSSSVEICTVVLTQTDPKEVQDSDLDEKETESNRIDDSIDGMIDTKFSLDVSKLQPVCSNDLSGTVIHSESLFSQSIPDTPQIGEKYKNDLLQVISPPTPVTNEDLGNCSEEIDDACLKFTGTERDVEGDSELWLEPSQFLAGEEDEGAIFDKWGRSCSSSPPTTHPDNTKASDYTWRENISIDHNAEDWELTFPPVERWSSSDSWASALSDWFQAVNTYPEDSFKSASTGSKLGMAIQDNILEQRTSSDNANNDEQTCLSLNLMQPDEPGQALERGLVKSDNTNGTVFKQGDKERLASCLDMDKDTTTMESQMSLLETSTPESHKADNNAVMETFNASLTHEFNAKLHGSLDISGKLLSAKREGNVLVEVTGGKVSQLGLVFEEERQSIFTSPSSSAYTRDKNLTGCVSNEERCHSSDVHLCICPSQSDSHVSSKAGHAEGNGSFLHSNIGNCTVKPYVEENIPQFIMPFAPICTGNTFLHRSFLKEDRSQADLDLPDKKIINKINLKSNKKSSSSDDSSEDNFHTCPDQSLSSSSGDSDDPSITDSGRKPAYSDTCDIGKELSKLLLLTGEHFMVSEDKRIAYVTLDLDESQHFGRFSLPNCEKQSKPDNMPHKTSKTSSDGKMRSKHKEKPDDKQQHGIQASKKQDPQPQSQVKNEGAGCEDCPVAVIETIVITEKIIPKTQGKKKKKHVQHGTPKPENDAPTDVRSESRQKNVNGKAENLELKVASNSLNKPVAQPSGKTDITKKDSAQKVMSVRPKVEPSMAKMDPAGVNATQKSSPIKLKADTFNTAKMENKTCTTDSLSTCLPSMLNDDIKRRRIADDLSRAVPIRTRPQLPAIFRQARKDGEDVTRRAYSEVVKQKNSTPKEVVVPRVVSEIQADPVPADPQNISLWCQFSPIPPEATIKWTKEAAVLSEINKVEKEDGRFTLTIIKACSKDLGFYKCSLIVANISVSTSEYHLTSEVLMELVIPSHDQPAEPRVMEGDEENIQCSPLLFKEDFLSDQYFGKNQPASILTEKVHFGEGMHRKAFRTTLTEGNLPRFRPGHPCVLKVHNSISYGTKNNEELVQKNYSLAVEECHVQNTAREYIKAYNSVAKSAESFGDLPEIIPIYLVHRPSNDIPYATLEEELLGDFVKYSVKDGKEINLMRRDSEAGQKCCAFQHWVYTQTEGNLLVTDMQGVGMKLTDVGIATCKKGYKGFRGNCATSFIDQFKALHQCNRYCELLGLVSLQPKPKRTVAPPKPKTQPVPKKKTFGPVLNAKS
What is the function of this protein?
Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (By similarity).  Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752).
What are the official names of this protein?
Alpha-protein kinase 2, Heart alpha-protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
What are the subcellular locations of this protein?
Basolateral cell membrane.
Protein: ILVC_METS4
Sequence: MRVYYDRDADINLIKGKKVVIVGYGSQGHAHALNLRDSGVKDIVIALRKGSASAKKAEAEGFKVMEVAEAAAQADVVMMLTPDELQGDIYRESLHGQMKQGAALLFAHGLNVHFNLIEPRKDLDVLMVAPKGPGHTVRSEYLRGGGVPTLIAIAQDASGNAHDLGLSYASANGGGRAGIIETTFKEECETDLFGEQVVLCGGLVELIKAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYEGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLTDIQSGTFTRNWMLENKVNQTSFKATRARNAAHPIEEVGERLRGMMPWIKEKALVDKTKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RL27_RHOPT
Sequence: MAHKKAGGSSRNGRDSAGKRLGVKAFGGEHVIPGNIIARQRGTQWHPGLNVGMGTDHTLFAKVEGRVEFRAKANGRTYVSVLPIAMQAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: VE7_OVPVD
Sequence: MACARPLTGRTLPADESPCLTLILEPVSGEAAKNSTPVVVDKPGKPPPKRHRRQYNVTVSCNDCDKRLNFSVKTTCSTILTLQQLLTEDLDFLCSFCEAKNG
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: RSMG_SALCH
Sequence: MLNKLSRLLADAGISLTDHQKTLLVAYVDMLHKWNKAYNLTSVRDPNEMLVRHILDSIVVAPYLQGQRFIDVGTGPGLPGIPLAIVLPDAHFTLLDSLGKRVRFLRQVQHELKLENITPVQSRVEAYPSEPPFDGVISRAFASLNDMVSWCHHLPGEKGRFYALKGQLPGDEIASLPDNFSVESVEKLRVPQLEGERHLVIIKSNKV
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUG2_SCHPO
Sequence: MKKENWQKIENVYLLGKKIDKAKRMANKGESNTNMLSTEENIVKAKAVSRKKPVDVSYAGLARHESHVDTDYHGQALNTDNQDPKNYQARSFVKENELYESSQDCGHSRLAQILSEENQIKRLPQSDNTTTERIIENNPNYSNKPSKLKRALSGENSVFSIHQRNTLSPSSNLPRIPSDLYDIKQFLENLDARSFKSDMDLKRSQNMRRRATGYPAIVVPFLNGSLPQADLPPLRTIEDIDNLTREQCLTFIQGYGIPIDSSDTVYLKEKLRDAIGMRAFTDMSFEMNSFHLESPR
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 2 protein.
What is the protein family that this protein belongs to?
Belongs to the UPF0612 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: 1433B_HUMAN
Sequence: MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.  Negative regulator of osteogenesis.  Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.  Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
What are the official names of this protein?
14-3-3 protein beta/alpha, Protein 1054, Protein kinase C inhibitor protein 1, KCIP-1.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. SUBCELLULAR LOCATION: Vacuole membrane. Note=(Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG.
Protein: HMFO_METS6
Sequence: MTDTIFDYVIVGGGTAGSVLANRLSARPENRVLLIEAGIDTPENNIPPEIHDGLRPWLPRLSGDKFFWPNLTIHRAAEHPGITREPQFYEQGRLLGGGSSVNMVVSNRGLPRDYDEWQALGADGWDWQGVLPYFIKTERDADYGDDPLHGNAGPIPIGRVDSRHWSDFTVAATQALEAAGLPNIHDQNARFDDGYFPPAFTLKGEERFSAARGYLDASVRVRPNLSLWTESRVLKLLTTGNAITGVSVLRGRETLQVQAREVILTAGALQSPAILLRTGIGPAADLHALGIPVLADRPGVGRNLWEHSSIGVVAPLTEQARADASTGKAGSRHQLGIRASSGVDPATPSDLFLHIGADPVSGLASAVFWVNKPSSTGWLKLKDADPFSYPDVDFNLLSDPRDLGRLKAGLRLITHYFAAPSLAKYGLALALSRFAAPQPGGPLLNDLLQDEAALERYLRTNVGGVWHASGTARIGRADDSQAVVDKAGRVYGVTGLRVADASIMPTVPTANTNLPTLMLAEKIADAILTQA
What is the function of this protein?
Involved in the degradation and detoxification of 5-(hydroxymethyl)furfural (HMF) by mediating its oxidation to furan-2,5-dicarboxylate (FDCA), a biobased platform chemical for the production of polymers.  Active with a wide range of aromatic and aliphatic primary alcohols and aldehydes: acts on alcohol groups and requires the spontaneous hydration of aldehyde groups for their oxidation (PubMed:24271187, PubMed:24802551).  To a lesser extent, is also able to catalyze the oxidation of thiols that are structurally similar to its alcohol substrates, yielding the corresponding thiocarbonyls (PubMed:25284255).
What are the official names of this protein?
5-(hydroxymethyl)furfural oxidase, 5-hydroxymethylfurfural oxidase, HMFO, Thiol oxidase.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: RED1_RAT
Sequence: MDIEDEENMSSSSIDVKENRNLDNMPPKDSSTPGPGEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMAPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGALLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDTAIEVINATTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSFTP
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing.  This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions.  Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing).  Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1).  Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities.  Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity).  Can inhibit cell proliferation and migration and can stimulate exocytosis.
What are the official names of this protein?
Double-stranded RNA-specific editase 1, RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=Shuttles between nucleoli and the nucleoplasm.