PharMolix/UniProtQA huggingface dataset:
Protein: YACG_SALCH
Sequence: MSDVTVVNCPTCGKPVVWGEISPFRPFCSKRCQLIDLGEWAAEEKRIASSGDQSDSDDWSEER
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: Y910_TREPA
Sequence: MNGAVRVVLTEVPRTVSLTEGALVCVRILSSTHAGRALVAINGERVRARVPQPMHKGAVLFLRASIRAGTVFLHPQCTSTPPSAEDMSAHFLQRWGVSFSPEAAALIHAHTSLCVPLQPQLIERFALLLKKFPEQKRAHAAFLASILGDRNIPVDAAMLRRMLSTFLGESGAYTDSDTERDLFALVNHTYHSALHWLLVPFERRGAHTVWRGTLSLLLHLHKKTCTQLRVRACNTAGEWVFCVQNNVLTVQRHAARELSRTAQKKTVARLCALLRERGIDFLSVRYGAHADSANDAVPFKGIDVSV
What are the official names of this protein?
Uncharacterized protein TP_0910.
Protein: METY1_THET8
Sequence: MRFETLQLHAGYEPEPTTLSRQVPIYPTTSYVFKSPEHAANLFALKEFGNIYSRIMNPTVDVLEKRLAALEGGKAALATASGHAAQFLALTTLAQAGDNIVSTPNLYGGTFNQFKVTLKRLGIEVRFTSREERPEEFLALTDEKTRAWWVESIGNPALNIPDLEALAQAAREKGVALIVDNTFGMGGYLLRPLAWGAALVTHSLTKWVGGHGAVIAGAIVDGGNFPWEGGRYPLLTEPQPGYHGLRLTEAFGELAFIVKARVDGLRDQGQALGPFEAWVVLLGMETLSLRAERHVENTLHLAHWLLEQPQVAWVNYPGLPHHPHHDRAQKYFKGKPGAVLTFGLKGGYEAAKRFISRLKLISHLANVGDTRTLAIHPASTTHSQLSPEEQAQAGVSPEMVRLSVGLEHVEDLKAELKEALA
What is the function of this protein?
Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway.  Has weak activity with O-acetyl-L-serine, O-phospho-L-serine, L-serine, O-succinyl-L-homoserine and L-homoserine.  Shows low CTT beta-lyase activity and very low CTT gamma-synthase activity.
What are the official names of this protein?
O-acetyl-L-homoserine sulfhydrylase 1, OAH-sulfhydrylase 1.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
Protein: RS20_BACFR
Sequence: MANHKSSIKRIRQEETRRLRNRYYGKTMRNAVRKLRSTTDKAEATAMYPGIVKMVDKLAKTNVIHKNKANNLKSKLAIYINKLA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RNC_CORDI
Sequence: MSRRKKRVTGEQALRLEFESVDHQPLIDALGVDIPRELLVLALTHRSFANENGMLPNNERLEFLGDSVLGLSVAGQLYQQYTSSPESDISKMRASIVSRYGLADIAREINLGQHILLGKGEQLHDGRSKDSILADTTEALLGAIYLAHGFEIARDTVLRLFKHKIDTASATGLHQDWKTTLQERLAERNLEMPTYTSTVTGPEHEQTFTAEVAVHGTVLGTGVGTNKKLAEQAAAHKAVGFLQDNPAFV
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPG_NEUCR
Sequence: MSSSSVVDHSPHDSAPSPLVPTASNLILIDNYDSFTWNVYQYLVLEGAKVTVFRNDQITIDELIAKNPTQLVISPGPGHPGTDSGISRDAIRHFAGKIPIFGVCMGQQCIFDVYGGDVCFAGEILHGKTSPLRHDGKGAYAGLSQDLPVTRYHSLAGTHVTLPECLEVTSWIAKEDGSKGVIMGVRHKEYTIEGVQFHPESILSAEGRGMFRNFLHMQGGTWAENERLQKAAQAQAANTKSDAPTPKKSNILQKIYAHRKAAVDAQKQIPSLRPSDLQAAYNLSIAPPQISLVDRLRNSPFDVALCAEIKRASPSKGVFALDIDAPSQARKYALAGASVISVLTEPEWFKGSIDDLRAVRQVLNGMPNRPAVLRKEFIFDEYQILEARLAGADTVLLIVKMLEYELLERLYKYSLSLGMEPLVEVQNTEEMATAIKLGAKVIGVNNRNLESFEVDLGTTGRLRSMVPSDTFLCALSGINTHQDVLDCKRDGVNGILVGEAIMRAPDATQFIRELCAGLTGPVPKSAAEPLLVKICGTRSAEAAAEAIKAGADLVGMIMVPGTKRCVDHETALSISQAVHMSKKTGSTEVSSQASKSARDFFNINAEIIRKRGPLLVGVFMNQPLEEVLEKQHLYDLDIVQLHGDEPLEWANLIPVPVVRKFKPGQVGLATRGYHAVPLLDSGAGSGTLLDLESVKKELEKDEQVTVLLAGGLEPSNVVETVKSLGPLSERVIGVDVSSGVEEGGKQSLEKIREFVKAAKSVR
What is the function of this protein?
Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
What are the official names of this protein?
Multifunctional tryptophan biosynthesis protein.
Protein: FRDD_SALEP
Sequence: MINPNPKRSDEPVFWGLFGAGGMWGAIIAPVIVLLVGIMLPLGLFPGDALSFERVLTFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTAIGVITL
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACON_ASPFU
Sequence: MISTRLARAGALAPKSRLFLGTRAFATVGDSPLDKKVEMANTEKGNYINYKKMSENLDIVRRRLQRPLTYAEKVLYSHLDDPHGQEIERGKSYLKLRPDRVACQDATAQMAILQFMSAGMPSVATPTTVHCDHLIEAQVGGDKDLARANEINKEVYDFLASATAKYNIGFWKPGSGIIHQIVLENYAFPGGLMIGTDSHTPNAGGLAMAAIGVGGADAVDVMAGLPWELKAPKVIGVKLTGEMSGWTTPKDVILKVAGLLTVKGGTGAIIEYHGPGVTSLSCTGMGTICNMGAEIGATTSMFPFNDRMYDYLKATKRQHIGDFAREYAKELREDEGAEYDQLIEINLSELEPHINGPFTPDLATPISKFKEAVETNKWPEELKVGLIGSCTNSSYEDMSRAASIARDALNHGLKAKSLFTVTPGSEQIRATIERDGQLQTLEEFGGVILANACGPCIGQWDRRDVKKGEPNSIISSYNRNFTGRNDANPATHAFVASPDLVVAMTIAGTLKFNPLTDKLKDKDGNEFLLQPPTGEGLPAKGYDPGRDTYQAPPADRSSVNVAVSPTSDRLQLLAGFEPWDGKDANGIPILIKCQGKTTTDHISMAGPWLKYRGHLDNISNNMLIGAVNAENGKANSVKNKFTGEYDAVPATARDYKARGVKWVVIGDWNYGEGSSREHAALEPRHLGGLAIITRSFARIHETNLKKQGMLPLTFADPADYDKINPEDTVDLLCTQLEVGKPMTLRVHPKDGSAPFDISLNHTFNESQIEWFKDGSALNTMARKSGAK
What is the function of this protein?
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle.  Also catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
What are the official names of this protein?
Aconitate hydratase, mitochondrial, Aconitase, Citrate hydro-lyase, Homocitrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CYNS_PYRTR
Sequence: MAQHPIATLNEELVPRLPPSSPTLFEAKKKKNLSFEAIAKHVGRDEVAIAALFYGQAMASAQDIKKLSEILDIDAGMLESQLSGFPNRGSTLDMPPKDPTIYRLYEIVQNYGQAYKAVLHEKFGDGIMSAISFSTKIEKETDDKGEWAKITLRGKWLPYSRF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: TLP1_ARTBC
Sequence: MQFKAIALTAIAAITPFTAAVGHAIVENHCDNNAYLWSVGGSVGPQQTITPGHTYSEQFRYDPVSGGIALKITRVKDGIYNGSPQTIFAYTLTDTNTFYDLSDVFGDAFAGTSGLLVSTSNPDCPDIWWPNGVPPTGQKFTSACQRDADITLTLCAQPPK
What is the function of this protein?
Might be involved in the inhibition of growth of fungal competitors and pathogenicity.
What are the official names of this protein?
Antigenic thaumatin-like protein ARB_01932.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CASK_ODOHE
Sequence: VALINNQFLPYPYYAKPGAVRSPAQILQWQVLPNTVPAKSCQAQPTTLARHPHPRLSFMAIPPKKNQDKTDIPTINTIATVESTITPTTEAIVDTVATPEASSEVIESAPETNTDQVTSTVV
What is the function of this protein?
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
What are the official names of this protein?
Kappa-casein.
What is the protein family that this protein belongs to?
Belongs to the kappa-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: CINAL_CHLL3
Sequence: MSERVPSIRAEIVSVGDELLKGQRVNTNASFIARSLGSVGIPVVRVTACSDFESEMASVFREALGRADVVLVTGGLGPTRDDRTRKAAGELLGLGLRLDPDALREVERRVTAHGRTMSELMQGQAMVLDGSRAIPNTRGTAAGMIIPAGERFGGSHLVLMPGVPVEMEAMMELTVQPWLRGLSDTTIIHTPVKTTGIGESTLADMLPDIEDSLPEGTSLAYLPHGAGVDLMVSTIARDPLRAERDNAAVVEAIRERAAAFIFAVGTASLEETIIGMLASGGLTLSVAESCTGGLIASRLTDVPGSSVSLMQGFIVYSNSAKEELLGVSRGLIDTHGAVSEEVACAMALGCLRRSGTSIALATTGIAGPGGGSPEKPVGTLCLAIARQVPGSGPSVGVRTLHMHGDRLQNKHRFSEAALRDLWVALRGEQGG
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: OR2S1_HUMAN
Sequence: MEKANETSPVMGFVLLRLSAHPELEKTFFVLILLMYLVILLGNGVLILVTILDSRLHTPMYFFLGNLSFLDICFTTSSVPLVLDSFLTPQETISFSACAVQMALSFAMAGTECLLLSMMAFDRYVAICNPLRYSVIMSKAAYMPMAASSWAIGGAASVVHTSLAIQLPFCGDNVINHFTCEILAVLKLACADISINVISMEVTNVIFLGVPVLFISFSYVFIITTILRIPSAEGRKKVFSTCSAHLTVVIVFYGTLFFMYGKPKSKDSMGADKEDLSDKLIPLFYGVVTPMLNPIIYSLRNKDVKAAVRRLLRPKGFTQ
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2S2, Olfactory receptor OR9-3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SECA2_BACAH
Sequence: MLNSVKKLLGDSQKRKLKKYEQLVQEINNLEEKLSDLSDEELRHKTITFKDMLRDGKTVDDIKVEAFAVVREAAKRVLGLRHYDVQLIGGLVLLEGNIAEMPTGEGKTLVSSLPTYVRALEGKGVHVITVNDYLAKRDKELIGQVHEFLGLKVGLNIPQIDPFEKKLAYEADITYGIGTEFGFDYLRDNMAASKNEQVQRPYHFAIIDEIDSVLIDEAKTPLIIAGKKSSSSDLHYLCAKVIKSFQDTLHYTYDAESKSASFTEDGIIKIEDLFDIDNLYDLEHQTLYHYMIQALRAHVAFQCDVDYIVHDEKILLVDIFTGRVMDGRSLSDGLHQALEAKEGLEITEENQTQASITIQNFFRMYPALSGMTGTAKTEEKEFNRVYNMEVIPIPTNRPIIREDKKDVVYVTADAKYKAVREDVLKHNKQGRPILIGTMSILQSETVARYLDEANITYQLLNAKSAEQEADLIATAGQKGQITIATNMAGRGTDILLGEGVHELGGLHVIGTERHESRRVDNQLKGRAGRQGDPGSSQFFLSLEDEMLKRFAQEEVEKLTKSLKTDETGLILTAKVHDFVNRTQLICEGSHFSMREYNLKLDDVINDQRNVIYKLRNNLLQEDTNMIEIIIPMIDHAVEAISKQYLVEGMLPEEWDFASLTASLNEILSVENMPSLSANNVHSPEDLQSVLKETLSLYKERVNELDSHTDLQQSLRYVALHFLDQNWVNHLDAMTHLKEGIGLRQYQQEDPTRLYQKEALDIFLYTYGNFEKEMCRYVARHLGVPENVQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 2.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: KINH_RAT
Sequence: MADPAECNIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTADKDVAITNDKPAAAIGMAGSFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLGEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKEKLITDLQDQNQKMVLEQERLRVEHERLKAVDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEVDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPGAVRGGGSFVQNNQPVGLRGGGGKQA
What is the function of this protein?
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.  Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity).  Regulates centrosome and nuclear positioning during mitotic entry.  During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity).  Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431).  Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends.  Involved in NK cell-mediated cytotoxicity.  Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity).
What are the official names of this protein?
Kinesin-1 heavy chain, Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytolytic granule membrane. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Uniformly distributed between soma and neurites in hippocampal neurons.
Protein: TRPD_BACC7
Sequence: MNNYLRKLVEGQHLTEEEMYKAGLLLLNENILESEIAAFLVLLKAKGETAEEIYGLVRALREKALPFSNHIQGAMDNCGTGGDGAQTFNISTTSAFVLAGADVKVAKHGNRAVSSKTGSADLLEELGVNISSTPNEIDYLLEHVGIAFLFAPAMHPALKRIMKIRKELNVPTIFNLIGPLTNPVNLETQFVGIYKRDMLLPVAQVLQKLGRKQALVVNGSGFLDEASLQGENHVVILKDNEIVETSIEPEKYGFSIVKNEEIRGGNSKENAKITLGVLSGEKSVYRDTVLFNAGLALFANGKAKTIEEGITLAAHSIDSGKALAKLNLLIAASNEKLERVN
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RL27_MARN8
Sequence: MAHKKAAGSTRNGRDSESKRLGVKRYGGESVSAGSIIVRQRGTRFHAGSNVGIGKDHTLFAKAEGQVKFETKGPQNRKFVSIVPAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RUVB_BACAA
Sequence: MDERLLSGESAYEDADLEYSLRPQTLRQYIGQDKAKHNLEVFIEAAKMREETLDHVLLYGPPGLGKTTLANIIANEMGVNVRTTSGPAIERPGDLAAVLTSLQPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATTRAGALSAPLRDRFGVLSRLEYYTVDQLSAIVERTAEVFEVEIDSLAALEIARRARGTPRIANRLLRRVRDFAQVRGNGTVTMEITQMALELLQVDKLGLDHIDHKLLLGIIEKFHGGPVGLETVSATIGEESHTIEDVYEPYLLQIGFLQRTPRGRIVTPLAYEHFGMEMPKV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: EFTU_FRATO
Sequence: MAKEKFERSKPHVNVGTIGHVDHGKTTLTAAITKVMAEKNGGMARKFDEIDSAPEEKARGITINTSHVEYESPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPKIVVFLNKCDMVDDEELLELVEMEVRELLDQYEFPGDDTPVIMGSALRAIEGDEAYVEKIVELVQAMDDYIPAPERDTEKPFILPIEDVFSISGRGTVVTGRIERGVVNVGDEVEVVGIRPTQKTTVTGVEMFRKLLDRGEAGDNVGILVRGLKRDDVERGQVLCKPGSIKPHTKFEAEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDITGAVELPEGVEMVMPGDNVKMTITLINPIAMDEGLRFAIREGGRTVGAGVVAKIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCCA_PIG
Sequence: MAGLWVGGSVLVAAGRRGSRSPRPLMRSVALWTLKHVPQYSRQRLLVSRSLCLAGYDSNEKTFDKILIANRGEIACRVIKTCKKMGIKTVAVHSDVDASSVHVTMADEAVCVGPAPTSKSYLNMDAIMEAVRTTRAQAVHPGYGFLSENKEFAKCLAAEGVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHRQADIPINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSNRMEALKRMENALDNYVIRGVTHNIALLREVIINSRFVEGDINTKFLSDVYPDGFKGHKLTEDERNQLLAIASSLFVASQLRAQRFQEPENSRVPIIKPQVANWELSIRLHDEVHTVTASNSGPTFSVEVDGSKLNVTSTWNLASPLLSVSIDGTQRTIQCLSRDAGGNMSIQFLGTVYKVHILTKLAAELNKFMLEKAAEDTSSILHSPMPGVVVAVSVKPGDLVAEGQEICVIEAMKMQNSMTAGKTGKVKSVHCKAGDTVGEGDLLVELE
What is the function of this protein?
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:13752080).  Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:13752080).  Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then tranfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity).  Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:13752080).  Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (PubMed:13752080).
What are the official names of this protein?
Propionyl-CoA carboxylase alpha chain, mitochondrial, PCCase subunit alpha, Propanoyl-CoA:carbon dioxide ligase subunit alpha.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NMB_HUMAN
Sequence: MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVHSRGNLWATGHFMGKKSLEPSSPSPLGTAPHTSLRDQRLQLSHDLLGILLLKKALGVSLSRPAPQIQYRRLLVQILQK
What is the function of this protein?
Stimulates smooth muscle contraction (By similarity).  Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).  Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity).  These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity).  Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity).  Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity).  Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264).  Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).
What are the official names of this protein?
Neuromedin-B.
What is the protein family that this protein belongs to?
Belongs to the bombesin/neuromedin-B/ranatensin family.
What are the subcellular locations of this protein?
Secreted. Cell projection, neuron projection. Note=In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex.
Protein: FER2_CAUVC
Sequence: MAKITYIQHDGAEQVIDVKPGLTVMEGAVKNNVPGIDADCGGACACATCHVYVDEAWLDKTGDKSAMEESMLDFAENVEPNSRLSCQIKVSDALDGLVVRLPESQH
What are the official names of this protein?
2Fe-2S ferredoxin, FdII.
What is the protein family that this protein belongs to?
Belongs to the adrenodoxin/putidaredoxin family.
Protein: MNMG_CAMHC
Sequence: MQYDIIVIGGGHAGIEACLAAARMGAKTLLITILAEQIGAASCNPAIGGLAKGHLVKEIDALGGQMGVCTDFAGIQFRTLNESKGPAVRGSRAQIDMDRYRIFMRNVLLNTSNLNISQEIATEILTENDQITGVKTHLGNVYETNRLIITTGTFLNGLIHVGENKLSAGRVGEFPSIRLSQSLKNLGLKMGRLKTGTCPRVDAKTIDFSALELQNGDAQAHPFSFKTRFFANEIEKFTKNLSKNFDENGNFNPTQIPCYITYTNEKTHEIIRNNFDRAPLFTGQIHGIGPRYCPSIEDKINKFADRDRHHVFVEPQTAEASEYYLNGLSTSLPYDVQVEFLHSVKGFENAKIVRHGYAIEYDFVEPTELKHSLETKKINGLYLAGQINGTTGYEEAAAQGLIAGINAALDIQNKAPLILRRDEAYIGVLIDDLVTKGTKEPYRMFTSRAEFRLLLREDNAIFRLSGYGHDIGLIKDYEFDEISRRKAQIQKGINFLLNNVITPNKENLAKLKSLGADAISQNTTWQKIVGGKNFSAEKIREIDSMFVDFSDDELSEILTECKYYFYIQMQKDEVAKMKNMLNTKIPTELDFSKISGLSNEIIEKLNKFNPPTLFAASEISGVTPAAIDILHIYIKQFKGK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_BORBR
Sequence: MSSRSYKRVLLKLSGEALMGEDAFGINRSTIVRMTDEIAEVAALGVELAIVIGGGNIFRGVAPGAQGMDRATADYMGMMATIMNALALQDALKHKGVDTRVQSALNIDQVVEPYIRPKALRYLEEGKVVIFAAGTGNPFFTTDTAAALRGAEIGAEIVLKATKVDGIYSADPNKDPTATRYARISFDEAIVRRLEVMDATAFALCRDQKLPIKVFSINKSGALKRAVSGEDEGTLVHV
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAR3_YEAST
Sequence: MNSGGSDSFDYLLQLTKALSAECRANRQETDRIELLLKRLAKQSGISYDNLSKNIIPDSWKDNASQKASPPTEAQKLISENFKLIYEIEKQEYFNTKAVALINNINEHFSYIKNFIDEQNAIRERNIATFSSEKLDERNKSLQQNYESLKTENEETKKKLHSIIKQFEKLLKEVDWDRISKDSRDYSRFKKQLEYLQDTYQVLK
What is the function of this protein?
Participates in the control of the reentry into the cell cycle following pheromone treatment.
What are the official names of this protein?
Factor arrest protein 3.
What are the subcellular locations of this protein?
Endoplasmic reticulum.