PharMolix/UniProtQA huggingface dataset:
Protein: GPSB_STRPD
Sequence: MTSIIYSPKDIFEQEFKTSMRGFDKKEVDEFLDNVIKDYENFNAQIEALKAENEALKKAKFQARNTVSATVQQPVPQPTRVAQSATNFDILKRISKLEKEVFGKQIIE
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: KLHDB_DROME
Sequence: MGDLPGSGSTAQPRDAAVTGTGGNSTAGGGSSVGSTAVDRPPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVMRAPQTENYMWCENSFKQPNS
What is the function of this protein?
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  May have a role in synapse differentiation and growth.
What are the official names of this protein?
Kelch-like protein diablo.
Protein: LISC_CHLRE
Sequence: MRSLATLHQSPASCSRSAPVAPCPARRANSSRRVARQGPRARASSPVVETESEDVDITPQIDAFEELVRLAVEKDPSLATLAEQHLRSKSKSAAPVSPFAAPSPGSPSASSMLGPSLGALPNQNKPAWLRQRAPQGEIYSGLKDQLRGLKLATVCEEAQCPNIGECWNGELATATIMLLGDTCTRGCRFCAVNTARTPPPPDPNEPVNTATAVASWGVGYVVLTSVDRDDMPDGGSEHFAATVRTLKQLRPGILVECLTPDFKGDLDAVRHLARSGLDVYAHNVETVERLQKRVRDPRAGYMQTLDVLRAAKECGVYTKSSIMLGLGETDDEVIDTMLDLKAVGVDIFTLGQYLQPTPHHLPVTEFVTPEKFEYWRKFGQEEIGFRYVASGPMVRSSYKAGEFFLHSMIESDRAKARAAQEGAAGRVRPL
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, chloroplastic, Lipoate synthase, LS, Lip-syn, Lipoate synthase, plastidial, LIP1p, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: USO1_BOVIN
Sequence: MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPNNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNTVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLETYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDSIVTHYKNMIREQDLQLEELKQQISTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKVQLGKDSQHQGPYTDGAQMNGVQPEEISRLREEIEELKSNRELLQSQLAEKDSLIENLKSSQLSPGTNEQSSATAGDSEQIAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSAPVPGESETVIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQNEKNKLEVDITDSKKEQDDLLVLLADQDQKIFSLKNKLKELGHPVEEEDELESGDQDDEDDEDEDDGKEQGHI
What is the function of this protein?
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane.  May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
What are the official names of this protein?
General vesicular transport factor p115, Protein USO1 homolog, Transcytosis-associated protein, TAP, Vesicle-docking protein.
What is the protein family that this protein belongs to?
Belongs to the VDP/USO1/EDE1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Note=Recycles between the cytosol and the Golgi apparatus during interphase.
Protein: REV_HV1BR
Sequence: MAGRSGDSDEDLLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTVLESGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: MUTS2_HALMA
Sequence: MDAALGPPEQMAELEEDLTPMMAQYYELCRQYDDALVLFQVGDFYEAFCAAAKRVARLCEITLTQREDSTGEYPMAGIPIDNAESYVETLLDAGYRVAIADQVEDPDEVSGVVERAVTRIVTPGTLTESELLGGADNNYVAALTAGERYGLALLDISTGDCYATSVGSESAVADELSRFGPAEAIVGPDVDVDRDAVFGPACLVTRYDADAFAQDRAEDRVGQYFGPPERLLAGGAEIRACGGLLAYAEYTRGSSGAVGPDGEPVDPDVDPAGTLDYLNHLTRYDPREYMLLDAVAVESLELFKRRSVRGHENRTLVDTVDETACALGRRKLTDWLRRPLLDADRIEARHGAVAELQRDPATREELSALLAEVYDLERLISRVSRGRANARDLRSLAATLSVVPDIRDHLADADARLLADLHATLDPLAETREEIEAAIRPDPPQQVTEGGVIREGYDEELDRLRSTEQSGKEWIDELEASERERTGIDSLKVGHTSVHGYYIEVTNANLDAVPEDYQRRQTLKNSERYYTPALKEREDEILRAESAADDLEYDLFCAVRDEVADEAERVQALADRLARLDVLVSFAEVAAQYDYCRPTVGSDGIDVTAGRHPVVERTEDAFIPNDTHLGSGPVPASRDGSDDGVTADDIQPFLAVVTGPNMSGKSTYMRQVALICLLAQSGSFVPAKAADLPILDRVFTRVGASDDIAGGRSTFMIEMTELATILDAATENSLVLLDEVGRGTSTADGLAIARAVTEYLHDEVGAYTLFATHHHDLTAVAAALSGATNRHFETSREDGDVRFDHELAPGPAAASYGVEVASMAGVPDSVVERSRDLLADAETADTGVEATRETEVASEPRPGTRADSETDSTATETTGPTENGAASAPAGEATSDDHAQEVFQTNGAAAEDELPESVAQQLASLDVATMTPIEAMNALADLQDRIE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS 2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RIP3_ORYSJ
Sequence: MAGAMTMSRRRLSHALLLVLAILPNLAALAVAAGGGSGGGGFFPHRSLLQSSSCQPSGAITGTSGDCNADNGSECCQDGVQYMTYACSPPVAAGGTGTAALLTLNSFADGGDGGGAPSCTGRFYDDGQLVVALSTGWFDGRSRCEKDVVIRASGGASVTAMVVDECDSQRGCDSDHNFEPPCRNNIVDGSPAVWDALGLNKDDGEAQITWSDA
What are the official names of this protein?
Ripening-related protein 3.
What is the protein family that this protein belongs to?
Belongs to the kiwellin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DEACT_BRUA4
Sequence: MISGEQAKPLLITNVKPVAFGVEHSDATTDILVGKDGSISAIGKSLNAPADVERVDGKGAWISPGWVDLHVHIWHGGTDISIRPSECGAERGVTTLVDAGSAGEANFHGFREYIIEPSKERIKAFLNLGSIGLVACNRVPELRDIKDIDLDRILECYAANSEHIVGIKVRASHVITGSWGVTPVKLGKKIAKILKVPMMVHVGEPPALYDEVLEILGPGDVVTHCFNGKSGSSIMEDEDLFNLAERCSGEGIRLDIGHGGASFSFKVAEAAIERGLLPFSISTDLHGHSMNFPVWDLATTMSKLLSVNMPFENVIEAVTHNPASVIKLSMENRLSVGQRADFTIFDLVDADLEATDSNGDVSRLNRLFEPRYAVIGAEAITASRYIPRARKLVRHSHGYSWR
What is the function of this protein?
Esterase that catalyzes the deacetylation of acetyl-(R)-mandelate (in vitro).  Can also hydrolyze acetyl glycolate, but with lower efficiency.  Has very low N-acetyl-D-amino acid deacetylase activity with N-acetyl-D-serine and N-acetyl-D-threonine (in vitro).  Theoretical substrate docking studies suggest that other N-acetylated amino acids may optimally occupy the active site and may in fact be the physiological substrates.
What are the official names of this protein?
Deacetylase Oant_2987.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Atu3266/EF_0837 deacetylase family.
Protein: CALCA_HUMAN
Sequence: MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRRRDLQA
What is the function of this protein?
CGRP induces vasodilation.  It dilates a variety of vessels including the coronary, cerebral and systemic vasculature.  Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.  It also elevates platelet cAMP.
What are the official names of this protein?
Calcitonin gene-related peptide 1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I.
What is the protein family that this protein belongs to?
Belongs to the calcitonin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBN1_ARATH
Sequence: MSEVNEMSGGSIGGELLRASPKVLTAGDRKLLKVELRPGDTTYVSWKKLMRDAGKVNGLSASVPDPPPNANPNLEFRIAPGHPVEIETNEQPHSNRFNAVIEKIERLYKGNDSSDGEELDGAPDDDEYDTEDSFIDDAELDEYFEVDNSTVKHDGFYVNRGKLERMEPSTTSNQQPKKRRRKDSAKPCRDAVDVSDKHTKLSITARKKDQSTAPGSWKTQESPLPSGAQDANTSVPLDDVKHSDRANHQSRNDTSHKSRETGSSSALHQKYSNKSLHQQSTSLLGKSPPNVFAEVTVVRQKENNGMHQLANVTGSRQSSQASKKDGSNVKSKTSILEKAIRELEKVVVESRPPAITENQEADTSSQAVKRRLPRDVKLKLAKVARIAQASQGKHSTELINRLMSIVGHLIQLRSLKRNLKIMIDMGDSATREKDTRFKQINNEVLDMIKAKVSLMESQAIKPEGATSDDFQDSVEKPSLKKFVMDAALEDKLCDLYDIFIDGLDEDQGPQTKKLYVNLAELWPNRLMDYRGIKHAIFRAKERRKALYGNLAKEMDQTKMKKSMKQLVPRTDCTAQPNTELVVQRQHSGEKKLIVDPNATSTSVVTSQTMVDRSNQQQPEKLKGISSSCNPTEETRVVKRKNEAVMAEKQVVLALKKPEHPQTRVIPAPQNLNIPRTTPDLNLPS
What is the function of this protein?
May be required for replication-independent chromatin assembly.
What are the official names of this protein?
Ubinuclein-1, AtUBN1, Ubiquitously expressed nuclear protein 1.
What is the protein family that this protein belongs to?
Belongs to the ubinuclein family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=Localized at rDNA loci in the nucleolus.
Protein: ALLR_ECOL5
Sequence: MTEVRRRGRPGQAEPVAQKGAQALERGIAILQYLEKSGGSSSVSDISLNLDLPLSTTFRLLKVLQAADFVYQDSQLGWWHIGLGVFNVGAAYIHNRDVLSVAGPFMRRLMLLSGETVNVAIRNGNEAVLIGQLECKSMVRMCAPLGSRLPLHASGAGKALLYPLAEEELMSIILQTGLQQFTPTTLVDMPTLLKDLEQARELGYTVDKEEHVVGLNCIASAIYDDVGSVVAAISISGPSSRLTEDRFVSQGELVRDTARDISTALGLKAHP
What is the function of this protein?
Negative regulator of allantoin and glyoxylate utilization operons.  Binds to the gcl promoter and to the allS-allA intergenic region (By similarity).
What are the official names of this protein?
HTH-type transcriptional repressor AllR, Negative regulator of allantoin and glyoxylate utilization operons.
Protein: ISPH_PELPB
Sequence: MNINLDRTSSGFCIGVQGTIYAAEEKLQQEGGLYSFGDIVHNEVEVKRLEALGLVTVDERAFRELRDAHVLIRAHGEPPSTYRIARENNLTVTDTTCPVVSRLQRTTRLLFELGYQIIIYGKQSHPEVIGINGQCNNQAVIIKHADLSDPDELKGLDLAKKSALISQTTMDVPGFYELKALLEARFAQYLSSEKSAWMAIRDIDITAAMTGVLSMPSLLFKDTICRQVSSRNQKLHDFSLANDVVIFVAGKKSSNGQVLYHICKEANPRSYFIEEIEEIEERWLRNSDGRAVATVGVCGATSTPMWHLEKVALHLEKNFAQ
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RPOZ_CARHZ
Sequence: MNQPSLDILMKKADSRYTLVVATAKRARQITAGESSKLKHISNKPVTIALHEIGNDLITYQRLKSSQNK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: YR267_MIMIV
Sequence: MNSATKFFKITNKKQKHYGHKYKKGINILPDKFNLTGSCVKGGFYFTNARNIFNYLEYNGYVGYYVREVYLPISDPEFIMVKDPDNDKSFMIMMNDPPGDKWRANKIILGSKLELSKLDTIKYLIQEGADPIIRNNLLIRWAVKNGYLEIIEYLLDIGANIRDYHNDAFKSTIKSGNNDMLKYLIIKGIDIHFDDNYAIKRAAYYGHYDVVKLLLEKGANIHTNYEEPIRLAAENGHYDVVVLLLNYGCDISAYHNYAIKTAARNGYYNVVLLVAKKLNEQGIRFDDALISACNTGSLSIIKLLIENGADYSYNDYEVFKLACKYGHINIVRYMFILGTDITIKNNYGLRWAARNGHLLVVEYLIEHGANIHAKNNYAIKWAFENDHYDVYTFLKEIQSINEIFEYIKYDRILMNIFYKIVNLTTCIINFDNL
What are the official names of this protein?
Putative ankyrin repeat protein R267.
Protein: PUR2_MYCLE
Sequence: MRVLVIGSGAREHALLLALSRDPQVKGLVVAPGNAGTARLAEQYDVDISSGEDIVALARDVRADMVVIGPELPLVLGVADAVRAAGIVCFGPSKDAARIEGSKAFAKEVMAAAGVRTSRSEIVNSPARLDAALDRFGPPVGDLSWVVKDDRLAAGKGVVVTSDRDVARTHAAGLLEAGHPVLLESYLDGPEVSLFCVVDGRTVLPLLPAQDFKRVGEGDTGPNTGGMGAYAPLPWLPDEVCQQALTSIVEPVAAELVQRGSPFRGLLYVGLAVTASGPAVVEFNCRFGDPETQVVLALLDSPLGQLLYAAGTGSLADFGELHWRSGAAVAVVLAAENYPRRPRVGDIVFGSEIEGVLHAGTTRRDDGVIVSSGGRVLSVVATGDDLSAARSQAYRIIGSIRLLGSHFRKDIGFSAAKGRIHI
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: CYB_MYOTR
Sequence: MTNIRKSHPLLKIVNSSFIDLPAPSNISSWWNFGSLLGICLALQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWILRYLHANGASMFFICLYLHVGRGLYYGSYMYTETWNVGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTSLVEWIWGGFSVDKATLTRFFAFHFLLPFIISAMVMVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDILGLLLMITVLLMLVLFSPDMLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVVALVLSILILVIIPFLHTSKQRSMTFRPLSQCLFWLLVADLLTLTWIGGQPVEHPYIIIGQLASILNFSIIIILMPLTSLVENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: QUEF_BACC1
Sequence: MAGRLDEDLKDVTLLGNQNTKYLFEYSPEILEVFDNNHPNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPEQRMVESKSLKLYLFSFRNHGDFHEDCMNVIMNDLIKLMDPRYIEVWGKFTPRGGISIDPYCNYGRPGTKYEQMADYRMMNHDLYPETIDNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_MYXXD
Sequence: MAKFDVVDLDLKKVSEIELSDDVFGTEPNAHLFYEVAKMQQINRRRGTVGVKNTSLVSGGGKKPWKQKGTGRARQGSIRASHWVGGGKAMAPKARDYFYRPPRKVRRGALKSALSLRAQEKTLIILDGFSLDAPKSKQAFEVLTKRLKLQNALVIDDKGNTNLHRSVRNLAKFDVLPPEGLNLEAVLRHSHLVLTSAAAKTLEGALS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RTKN2_MOUSE
Sequence: MEGQLLRGLAAQQDCSIREKIDLEIRMREGIWKLLSLSTKKDQVLHAVKNLMVCSARIQAYTAELQKSKEEIANQTGARLVLDSSSENKEGESCRGKIALSDIRIPLMWKDSDHFSNKECTQRFAIFCLFRMGAQVFDTDMVIVDQTVTDICFENVTIFNEAGPDFQIKIEVYSCSAEESSLTNTPRKLAKKLKTSISKATGRKISAALQEESPEACLLAGSVAGAKYHLLAHTTLTLENAGDCFKTHNLSVHGDEECSFWLPLYGNVCCRLVAQPACMAADAFAGFLNEQQTGKGLVGWRRLYCALRGGKLRCFYGPEEIEAKVEPALVVPIDKETRIQAVEKDSKKMHCFSVLSTAAGRAVSHIFAADSLADFQEWMGAFRQHFFDLSQWKHCCEELMRIEIMSPRKPPLFLAKEATSVYYDMSIDSPVKLESVTDIIQKKIGETNRQFLIGRDDQSAAPPWAAVFDGNHEMVIEKKVLSPIGEPAPDGKRKKRRAPLPPTDQPPFCIKTQGRANQSKDSATQAGVSGASSSPSDPRLSPPTHHLQKPVAAPRKLLPARKNSSADIGHTDTKTSLDAKPVPVPRQKSIRDILDPRSWLQAQV
What is the function of this protein?
May play an important role in lymphopoiesis.
What are the official names of this protein?
Rhotekin-2, Pleckstrin homology domain-containing family K member 1, PH domain-containing family K member 1.
Protein: ILVC_SACS2
Sequence: MKCTSKIYTDNDANLDLIKGKRIAVLGYGSQGRAWAQNLRDSGLNVVVGLEREGKSWELAKSDGITPLHTKDAVKDADIIIFLVPDMVQRTLWLESVQPYMKKGADLVFAHGFNIHYKLIDPPKDSDVYMIAPKGPGPTVREYYKAGGGVPALVAVHQDVSGTALHKALAIAKGIGATRAGVIPTTFKEETETDLFGEQVILVGGIMELMRAAFETLVEEGYQPEVAYFETINELKMLVDLVYEKGISGMLKAVSDTAKYGGMTVGKFVIDESVRKRMKEALQRIKSGKFAEEWVEEYGRGMPTVVNGLSNVQNSLEEKIGNQLRDLVQKGKPKS
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: S7A14_BOVIN
Sequence: MSGFLTSLDPRRVQWGAAWYAMHSRILRTKPVESMLEGTGATTAHGTKLAQVLTTMDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTISRWMVDSVGTLNGLGKGEQSYPDLLALVIAIIVTIIVALGVKNSVGFNNVLNVLNLAVWVFIMIAGFFFINGKYWAEGQFLPYGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSMILTLMVPYDTIDTESPLMEMFVARGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLSLLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKEVCSPVSEGEEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPRYYTMRIQLGLPGKMDRPTAATGHTVTICVLLLFILMFVFCSFIIFGSDYISEQSWWAILLVVLMVLLISALVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGMLIYFGYGIWNSTLEISAREEALHQSTYQRYDVDDPFSVEEGFSYATEGESQENWGGPAEDKGFYYQQMSDTQPNTRTSSKAKSKSKHKQNSEALIANDELDYSPE
What are the official names of this protein?
Probable cationic amino acid transporter, Solute carrier family 7 member 14.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS9_BUCAP
Sequence: MVKIQNYGTGRRKSSSARVFLRSGDGEITVNKRSLKDYFGRETSCMVVRQPLELVDMMNNFNIYITVKGGGVSGQAGAIRQGITRALIKYNHLLRSELRKSGFVTRDSRQVERKKVGFRKSRKRTQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: PA2H3_BOTAS
Sequence: MRTLWIMAVLLVGVEGSLVELGKMILQETGKNPVTSYGAYGCNCGVLGRGKPKDATDRCCYVHKCCYKKLTGCNPKKDRYSYSWKDKTIVCGENNSCLKELCECDKAVAICLRKNLDTYNKKYKNNYLKPFCKKADPC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks enzymatic activity.  Is myotoxic (By similarity).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog M1-3-3, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.