PharMolix/UniProtQA huggingface dataset:
Protein: TAT_HV1A2
Sequence: MEPVDPNLEPWKHPGSQPRTACNNCYCKKCCFHCYACFTRKGLGISYGRKKRRQRRRAPQDSQTHQASLSKQPASQSRGDPTGPTESKKKVERETETDPFD
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: LPXK_CHLPN
Sequence: MKKRFPSTLFLFYRRVTIAISLEGILGWGWLGSLLSKVFAFLVACWNRFSWSTPYRARSTVISVGNIVVGGAGKTPTVLWLAEALRLRGYSCGVLSRGYKSQSSRQKKLTVVDSKVHSASYVGDEPLLMAEKLPEGSVWVHKDRRISAARAAEKFGILLLDDGLQYRKLHKDVEIAVVNGQDPLGGRAFFPKGRLRDFPLRLKTVDAIIVNGGGKEAGTVVKRVSNAPQIFVKPTIASVVWTHNGERIPKEALRELRVGVFCGLGFPQGFLNMLREEGIHILGKYLLPDHAAITKKELNYFCQQMAMRQGQGLLCTEKDSVKLPRLSGEVSLLPIAKVEMRLSVNQDDTLSLLNMIEQIHKNRGN
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: PALB2_MOUSE
Sequence: MEELSGKPLSYAEKEKLKEKLAFLKKEYSRTLARLQRAKRAEKAKNSKKAIEDGVPQPEASSQLSHSESINKGFPCDTLQSNHLDEETGENISQILDVEPQSFNCKQGKEVLHTPRAGDIQGQLLHSTSSPDGKKEQNTLPGTTKTPWEKSSVSQEKEDYFDTNSLALLGKHRKGQESISRKNSRTPVSEKTHLLSLRSQIPDPPALVTGIGEGILIPPSGKSERGIDTLVRGNTVSAEAAVPSCTASNSNHSQHLEHTPPKSGCKITTQGPASSTNLVAQDQKMTIFTVNSVVYKAVRAHGQLPGSPNSCSVNDLTHSNLPANSTPNSKSLKSPSNTVDERNEPLQEDEILGPSKNFNLAAVSPPSTESQIHSCTMLEGLLFPAEYYVRTTRRMSDCQRKIALEAVIQSHLGVKKKELKKKTKATKAVVLSSEDTDQSESGMLDTSTGQSSSGSLSQKLLSPAEVSSPPGPAGKATTPPPGRGHRGKRKSARTSTLGHCQLLFPPCAALAVNRSKGKFTKHKCQNRGVVIHDFELPDEDFGLLKLEKLKSCSEKLIESPDSKNCGERLPREGNHAALEELQRDSETEGLEEELTVPPGEAYRPGPTLRRQPGSKDLSSSIVLFTPADTAAPNDSGRPPPSLCSPAFPILGMTPALGSQAAGETLSTEAAQPCSTSQPPLLGDTNSLVNNSKQCNSSACSPKPDTNLQASGRQGQPACDSDSGPQATPLPVESFTFRENQLCGNACLELHEHSTEQTETADRPACDNLNPGNLQLVSELKNPSSSCSVDVSAMWWERAGAKEPCIVTACEDVVSLWKPLNSLQWEKVHTWHFTEVPVLQIVPVPDVYNLICVALGSLEIREIRALLCSSGDDSEKQVLLKSGDIKAMLGLTKRRLVSSTGTFCNQQIQIMTFADDGSSKDEQLLMPPDETVLTFAEVQGTQEALLGTTTVNSIVIWNLKTGQLLKKMHIDDSYQASVCHGAYSEKGLLFVVVSQPCAKESQALGSPVFQLLVINPKTAQSVGVLLCSLPQGQAGRFLEGDVKDHVAAAVLTSGTIAIWDLLLGHCTALLPPVSDQSWSLVKWSGTDSHLLAGQKDGNIFIYRYF
What is the function of this protein?
Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks.  Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA).  Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51.  Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination.  Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair.  Essential partner of BRCA2 that promotes the localization and stability of BRCA2.  Also enables its recombinational repair and checkpoint functions of BRCA2.  May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation.  Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures.  May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (By similarity).
What are the official names of this protein?
Partner and localizer of BRCA2.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with BRCA2 in nuclear foci.
Protein: SYC_NEIG1
Sequence: MTAIYNTLTRQKEPFAPIDPENVRMYVCGMTVYDYCHLGHARVMVVFDMIARWLRECGYPLTYVRNITDIDDKIIARAAENGETIGELNARFIQAMHEDADALGVLRPDIEPKATENIPQMIAMIETLIQNGKAYPAANGDVYYAVREFAAYGQLSGKSLDDLRAGERVEVDGFKRDPLDFVLWKAAKAGEPAWESPWGNGRPGWHIECSAMSENLFGDTFDIHGGGADLQFPHHENEIAQSVGASGHTCGHDHAQTHHGQSIASHVKYWLHNGFIRVDGEKMSKSLGNFFTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHLDDAKGALTRLYTTLKNTPAAEFDLSENANGYTRRFYAAMNDDFGTVEAVAVLFELAGEVNKTNDAHLAGCLKALGGIIGLLQRNPIEFLQGGAVSDGLSNEEIEDLIARRKQARADKNWAESDRIRDLLNEHKIILEDSAGGTTWRRG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_PSEPG
Sequence: MSAQIIAIDAMGGDFGPRSIVQASIACLSATPSLHLTLVGQPSLLEDLVSGLAAADRARLQIVAASEVIGMDERPSQALRGKPDSSMRIALELVRDGKAQACVSAGNTGALMALSRFVLKTLPGIDRPAMVAAIPTQAGYCQLLDLGANVDCSAENLYQFAVMGSVAAQALGVHRPRVALLNIGTEDIKGNQQVKLAASLLQNARGLNYVGFVEGDGLYRGEADVVVCDGFVGNILLKSSEGLATMIGARIEQLFKGGVLSRAAGAVAMPLLKRLQADLAPARHNGASFLGLQGIVIKSHGSAGVQGFQSAIQRALIEIQENLPQRLHGRLEDLLL
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: BIOA_ECOLI
Sequence: MTTDDLAFDQRHIWHPYTSMTSPLPVYPVVSAEGCELILSDGRRLVDGMSSWWAAIHGYNHPQLNAAMKSQIDAMSHVMFGGITHAPAIELCRKLVAMTPQPLECVFLADSGSVAVEVAMKMALQYWQAKGEARQRFLTFRNGYHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPAPQSRMDGEWDERDMVGFARLMAAHRHEIAAVIIEPIVQGAGGMRMYHPEWLKRIRKICDREGILLIADEIATGFGRTGKLFACEHAEIAPDILCLGKALTGGTMTLSATLTTREVAETISNGEAGCFMHGPTFMGNPLACAAANASLAILESGDWQQQVADIEVQLREQLAPARDAEMVADVRVLGAIGVVETTHPVNMAALQKFFVEQGVWIRPFGKLIYLMPPYIILPQQLQRLTAAVNRAVQDETFFCQ
What is the function of this protein?
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA) (PubMed:1092681, PubMed:1092682).  It is the only animotransferase known to utilize SAM as an amino donor (PubMed:1092681, PubMed:1092682).  Complements a bioU deletion in Synechocystis PCC 6803 (PubMed:32042199).
What are the official names of this protein?
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, 7,8-diamino-pelargonic acid aminotransferase, DAPA AT, DAPA aminotransferase, 7,8-diaminononanoate synthase, DANS, Diaminopelargonic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C79B1_SINAL
Sequence: MNTFTSNSSDLTSTTKQTLSFSNMYLLTTLQAFVAITLVMLLKKVLVNDTNKKKLSLPPGPTGWPIIGMVPTMLKSRPVFRWLHSIMKQLNTEIACVRLGSTHVITVTCPKIAREVLKQQDALFASRPMTYAQNVLSNGYKTCVITPFGEQFKKMRKVVMTELVCPARHRWLHQKRAEENDHLTAWVYNMVNNSDSVDFRFVTRHYCGNAIKKLMFGTRTFSQNTAPNGGPTAEDIEHMEAMFEALGFTFSFCISDYLPILTGLDLNGHEKIMRDSSAIMDKYHDPIIDARIKMWREGKKTQIEDFLDIFISIKDEEGNPLLTADEIKPTIKELVMAAPDNPSNAVEWAMAEMVNKPEILRKAMEEIDRVVGKERLVQESDIPKLNYVKAILREAFRLHPVAAFNLPHVALSDATVAGYHIPKGSQVLLSRYGLGRNPKVWADPLSFKPERHLNECSEVTLTENDLRFISFSTGKRGCAAPALGTALTTMLLARLLQGFTWKLPENETRVELMESSHDMFLAKPLVMVGELRLPEHLYPTVK
What is the function of this protein?
Converts tyrosine to para-hydrophenylacetaldoxime in para-hydroxybenzylglucosinolate biosynthesis.
What are the official names of this protein?
Cytochrome P450 79B1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL23_METVS
Sequence: MDAFDVIKTPIVSEKTMKLIEEENRLVFYVERKATKEDIKEAIKQLFNAEVAEVNTNITPKGQKKAYIKLKDEYNAGEVAASLGIY
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23, ML7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: BTUB_ECOL5
Sequence: MIKKASLLTACSVTAFSAWAQDTSPDTLVVTANRFEQPRSTVLAPTTVVTRQDIDRWQSTSVNDVLRRLPGVDITQNGGSGQLSSIFIRGTNASHVLVLIDGVRLNLAGVSGSADLSQFPIALVQRVEYIRGPRSAVYGSDAIGGVVNIITTRDHPGTEISAGWGSNSYQNYDVSTQQQLGDKTRVTLLGDYAHTHGYDVVAYGNTGTQAQPDNDGFLSKTLYGALEHNFTDVWSGFVRGYGYDNRTNYDAYYSPGLPLVDTRKLYSQSWDAGLRYNGELIKSQLITSYSHSKDYNYDPHYGRYDSSATLDEMKQYTVQWANNIIIGHGNIGAGVDWQKQSTAPGTAYVEDGYDQRNTGIYLTGLQQVGDFTFEGAGRSDDNSQFGRHGTWQTSAGWEFIEGYRFIASYGTSYKAPNLGQLYGSYGNPNLNPEKSKQWEGAFEGLTAGVNWRISGYRNDVSDLIDYDDHTLKYYNEGKARIKGVEATANFDTGPLTHTVSYDYVDARNAITDTPLLRRAKQQVKYQLDWQLYDFDWGITYQYLGTRYDKDYSSYPYQTVKMGGVSLWDLAVAYPVTSHLTVRGKIANLFDKDYETVYGYQTAGREYTLSGSYTF
What is the function of this protein?
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space.  It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
What are the official names of this protein?
Vitamin B12 transporter BtuB, Cobalamin receptor, Outer membrane cobalamin translocator.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: METK_VIBPA
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVMVGGEITTSAWVDIEELTRETVREIGYVHSDMGFDANSCAVLNTIGKQSPDINQGVDKADPKEQGAGDQGIMFGYACNETEVLMPAPITYSHRLVEKQAEVRKNGTLPWLRPDAKSQVTFQYDQGKIVGIDAVVLSTQHCDSISTPDLREAVMEEIIKPVLPAEWISKDTNFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGAARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGMADRCEIQLSYAIGVADPTSIMVETFGTEKVSHDIIIEAVRQFFDLRPYGLQEMLNLLQPIYKKTAAYGHFGREEFPWEATDKAELLRDFAGIK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_SALAI
Sequence: MAAGVKAAELRELSEEELVTKLREAKAELFNLRVQAATGQLDNNRRLQVIRREIARIYTIMRERELGLSAAPTEVTAG
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: GREA_VESOH
Sequence: MNNIPVTAFGAKALEAALLKLKDVSRPRIIEDIRIARAHGDLKENAEYHAAKEEQSFVEGRIKEIELKLSRMQIIDVTKLSQDGRCVFGTTITLMNSVDNSEITYQIVGEDEADISLDKISCHSPIASALMGNEEGDKVIVKAPKGDIVYKILSVEYYI
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: GP_UUKS
Sequence: MVRTYLLLLLLCGPATPFFNHLMDVTRRLLDSSNATWQRDQPDTHRLSRLDAHVMSMLGVGSHIDEVSVNHSQHLHNFRSYNCEEGRRTLTMMDPKSGKFKRLKCNENQTLSKDCASCIEKKSSIMKSEHLVYDDAICQSDYSSPEAMPDHETHLCRIGPLHIQHCTHEAKRVQHVSWFWIDGKLRVYDDFSVSWTEGKFLSLFDCLNETSKDHNCNKAVCLEGRCSGDLQFCTEFTCSYAKADCNCKRNQVSGVAVVHTKHGSFMPECMGQSLWSVRKPLSKRSVTVQQPCMDCESDCKVDHILVIVRHFYPDHYQACLGSTCLTGRAKDKEFKIPFKMADRLSDSHFEIRIWDKERSNEYFLESRCESVDACAAITCWFCRANWANIHCFSKEQVLILVAVSSLCILLLASVLRALKVIATFTWKIIKPFWWILSLLCRTCSKRLNKRAERLKESIHSLEEGLNNVDEGPREQNNPARAVARPNVRQKMFNLTRLSPVVVGMLCLACPVESCSDSISVTASSQRCSTSSDGVNSCFVSTSSLLQVSPKGQESCLILKGPTGTAVDSIRIKTTDIKLECVRRDLYWVPRVTHRCIGTRRCHLMGACKGEACSEFKINDYSPEWGHEEELMAQLGWSYCVEQCGGALCQCFNMRPSCFYLRKTFSHLSQDAFNIYECSEWSYRINVLVSTNSTHSNLTLKLGVPDSIPHGLISLSSVSQPPAIAYSECFGEDLHGTKFHTVCNRRTDYTLGRIGEIQCPTKADALAVSKRCISSDSIIFSKVHKDSVDCQSSIIDPMTIRNRNKLPSTVGSVTFWPTETSVEAAIPDLASATMLIRLDGYTIQFRSDSNKCSPRFLSLSGCYNCEAGAKLELEHVTDFGTALGILECPSLGYTTYYEVKNTLEKSIRTMHLNGSHVEAKCYFRCPNSESQLTIRGELIYLFNDDIRHHNQTLSPGLSPKSGSGWDPFGWFKASWLRAIWAILGGTVSLIIGVVIIYMVFTLCLKVKKS
What is the function of this protein?
Structural component of the virion that interacts with glycoprotein N (PubMed:1988460).  Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (By similarity).  The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:18272496).  They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (PubMed:20542252).
What are the official names of this protein?
Envelopment polyprotein, M polyprotein, p110.
What is the protein family that this protein belongs to?
Belongs to the phlebovirus envelope glycoprotein family.
What are the subcellular locations of this protein?
[Glycoprotein N]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein C to the Golgi complex, where virion budding occurs. SUBCELLULAR LOCATION: [Glycoprotein C]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein C to the Golgi complex, where virion budding occurs.
Protein: DLG4_RAT
Sequence: MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDAGDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
What is the function of this protein?
Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed:15317815, PubMed:15358863, PubMed:19596852, PubMed:23300088, PubMed:26679993, PubMed:20628354).  Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels.  Required for synaptic plasticity associated with NMDA receptor signaling.  Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons.  May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly.  May regulate the intracellular trafficking of ADR1B (By similarity).  Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:19596852). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity).
What are the official names of this protein?
Disks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 90, SAP-90, SAP90.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Postsynaptic density. Synapse. Cytoplasm. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Presynapse. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4 (PubMed:19596852).
Protein: GARL_SALTI
Sequence: MNNAIFPNKFKAALAAQQVQIGCWSALASPITTEVLGLAGFDWLVLDGEHAPNDVTTLIPQLMALKGSASAPVVRVPTNEPVIIKRMLDIGFYNFLIPFVETQEEAARAVASTRYPPEGIRGVSVSHRANMFGTVPDYFAQSNKNITIIVQIESQLGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGNASHPDVQQTIQHIFARAKAHGKPCGILAPVEADARRYLEWGATFVAVGSDLGAFRASTQKLADTFKK
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
What are the official names of this protein?
5-keto-4-deoxy-D-glucarate aldolase, KDGluc aldolase, KDGlucA, 2-dehydro-3-deoxy-D-glucarate aldolase, 2-keto-3-deoxy-D-glucarate aldolase, 5-dehydro-4-deoxy-D-glucarate aldolase, Alpha-keto-beta-deoxy-D-glucarate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
Protein: LEU1_KLEP7
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEYANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFNVQSGSSDIATASIKLVCGDEIKTEAANGNGPVDAIYQAINRVTDYNIELVKYGLSAKGHGKDALGQVDIVVDYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: WSB1_TAKRU
Sequence: MASFPESVNENDIDKAKFIGELLVPMAPFDQKAGREAWTVAFAPDGSYFAWSQGHRIVRLIPWAKCLSSFSVRHGGEVTNPTSPRHLSRQSCKGGSVIPMAGAPPEHTIDCGGIVWGMAFGSSVPEKQSRSINIEWHHFQFGRDQLLLATGLNNGRIKIWDVYTGTLLLNLMDHTDIVRDLTFAPDGSLMLVSASTDKKLRVWDLKDDGNMVKVLWGHPNRVYSSAFSPDSSVLCSVGASKAVLLWNMDKYTLIRKLEGHHNDVVSCEFSPDGALLATASYDTRVIVWDHQRGSILLELGHLFPPPSPIFAGGANDRWVRSVSFCADGRHIASVSDDRLVRFWSIEERAPQAVASLPNGLCCAFSTTGSVLAAGTCDGSVHFWECPRSIASLQHLCRMALRRVKTTQQVEALPVPMPLRDFLTYRVV
What is the function of this protein?
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
WD repeat and SOCS box-containing protein 1, WSB-1.
Protein: YBFE_BACSU
Sequence: MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFALIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE
What are the official names of this protein?
Uncharacterized protein YbfE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DER_CAMJD
Sequence: MQSIILIGKPNVGKSSLFNKMARQRIAITSDISGTTRDANKTEIYIHSKKAMLIDSGGLDESDELFKNVKKNTLKVAKESDIILYLVDGKLAPDDEDRQFFYSLKKLGKPIALVINKVDNKKDEERAWEFANFGVKEIFNLSVTHNVGLDELYEWLEKFLHQEFLIPDEEENLEDFLEYYEEGKEFQFKEVDQNHIRVGIVGRVNVGKSSLLNALVKQERSVVSSIAGTTIDPVNESIVHKDKVIEFVDTAGIRKRGKIQGLERFALNRTEKILSHSQIALLVLDTHEGFNELDERIAGLVVKHYLGVIIVLNKWDKSEMDFDKTVKELRLDRFKFLAYAPVISVSALSGKRVHVLLDKILQIFENFTQKIQTSKLNTLIENATRAHPLPHDYGKLVKIYYAVQYDLAPPKIALIMNRPKALHFSYKRYLQNQIRKEFNFEGVPLVIASRKKGSKENDES
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: VATB_CYACA
Sequence: MEAFNLHKKAVSRDYIVKPRLEYRTVSAVNGPLIILQNVKSPRFAEIVNVTLGDGSVRRGQVLEINQDKAVVQIFEGTTGIDNKKTVCQFTGEILKTPVSLDMLGRVFNGSGKPIDGGPPILPEAYLDIQGQPINPQSRTYPEEMFETGISSIDVMNSIARGQKIPLFSGAGLPHNEVAAQICRQVCLVSTCTLVKRSGKDEEDFAIVFAAMGVNMETARFFRQDFEENGAMERVTLFLNLANDPTIERIITPRLALTFAEYLAYEKGKHVLVILTDMSAYADALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRVEGRPGSITQLPILTMPNDDITHPIPDLTGYITEEQIYLDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHSDVSNQLYAAYAMGKDALAMRAVVGVEALSQEDLLYLEFHDKFERRFVNQGAYERRDIYTSLDMAWDLLRIFPVQMLRRIPEKILQEYYHRTSNYEHKENKPHSSRS
What is the function of this protein?
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase subunit B, V-ATPase subunit B, Vacuolar proton pump subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.