PharMolix/UniProtQA huggingface dataset:
Protein: MURA_HAEIE
Sequence: MDKFRVYGQSRLSGSVNISGAKNAALPILFAAILATEPVKLTNVPELKDIETTLNILRQLGVIANRDETGAVLLDASNINHFTAPYELVKTMRASIWALAPLVARFHQGQVSLPGGCSIGARPVDLHISGLEKLGADIVLEEGYVKAQVSDRLVGTRIVIEKVSVGATLSIMMAATLAKGTTVIENAAREPEIVDTADFLNKMGAKITGAGSDHITIEGVERLTGCEHSVVPDRIETGTFLIAAAISGGRVVCQNTKADTLDAVIDKLREAGAQVDVTENSITLDMLGNRPKAVNIRTAPHPGFPTDMQAQFTLLNMVAEGTSIITETIFENRFMHIPELIRMGGKAEIEGNTAVCHGVEQLSGTEVIATDLRASISLVLAGCIATGETIVDRIYHIDRGYEHIEDKLRGLGAKIERFSGSDEA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HST2_CANAL
Sequence: MPSLDDILKPVAEAVKNGKKVTFFNGAGISTGAGIPDFRSPDTGLYANLAKLNLPFAEAVFDIDFFKEDPKPFYTLAEELYPGNFAPTKFHHFIKLLQDQGSLKRVYTQNIDTLERLAGVEDKYIVEAHGSFASNHCVDCHKEMTTETLKTYMKDKKIPSCQHCEGYVKPDIVFFGEGLPVKFFDLWEDDCEDVEVAIVAGTSLTVFPFASLPGEVNKKCLRVLVNKEKVGTFKHEPRKSDIIALHDCDIVAEKLCTLLGLDDKLNEVYEKEKIKYSKAETKETKMHEIEDKLKEEAHLKEDKHTTKVDKKEKQNDANDKELEQLIDKLKI
What is the function of this protein?
NAD-dependent histone deacetylase that is involved in nuclear silencing events.  Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing.  Its function is negatively regulated by active nuclear export (By similarity).
What are the official names of this protein?
NAD-dependent protein deacetylase HST2, Homologous to SIR2 protein 2, Regulatory protein SIR2 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VGP_EBOG4
Sequence: MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETRYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNRAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSLRPPITKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNASTTSDTPPATTAAGPLKAENTNTSKGTDLLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRTRREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYIEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in GP2, releasing the fusion hydrophobic peptide.
What are the official names of this protein?
Envelope glycoprotein, GP1,2, GP.
What is the protein family that this protein belongs to?
Belongs to the filoviruses glycoprotein family.
What are the subcellular locations of this protein?
[GP2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In the cell, localizes to the plasma membrane lipid rafts, which probably represent the assembly and budding site. SUBCELLULAR LOCATION: [GP1]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=GP1 is not anchored to the viral envelope, but forms a disulfid-linked complex with the extravirion surface GP2. In the cell, both GP1 and GP2 localize to the plasma membrane lipid rafts, which probably represent the assembly and budding site. GP1 can also be shed after proteolytic processing. SUBCELLULAR LOCATION: [Shed GP]: Secreted. Note=GP2-delta bound to GP1 (GP1,2- delta) is produced by proteolytic cleavage of GP1,2 by host ADAM17 and shed by the virus.
Protein: MDTC_SALTI
Sequence: MRFFALFIYRPVATILIAAAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILEFNFDRDINGAARDVQAAINAAQSLLPGGMPSRPTYRKANPSDAPIMILTLTSESWSQGKLYDFASTQLAQTIAQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDEVREAIDSANVRRPQGAIEDSVHRWQIQTNDELKTAAEYQPLIIHYNNGAAVRLGDVASVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDGIRAKLPELRAMIPAAIDLQIAQDRSPTIRASLQEVEETLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEARMKPLQAALQGTREVGFTVISMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLVVSLTLTPMMCGWMLKSSKPRTQPRKRGVGRLLVALQQGYGTSLKWVLNHTRLVGVVFLGTVALNIWLYIAIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVNNVTGFTGGSRVNSGMMFITLKPRGERKETAQQVIDRLRVKLAKEPGAKLFLMAVQDIRVGGRQANASYQYTLLSDSLPALREWEPKIRKALSALPQLADVNSDQQDNGAEMNLIYDRDTMSRLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYSQDISALEKMFVINRDGKAIPLSYFAQWRPANAPLSVNHQGLSAASTIAFNLPTGTSLSQATEAIDRTMTQLGVPSTVRGSFSGTAQVFQQTMNSQLILIVAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRSGGLTPEQAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKNSKPVVEI
What are the official names of this protein?
Multidrug resistance protein MdtC, Multidrug transporter MdtC.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RDRP_I56A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGRWTKNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLMANESGRLIDFLKDVMESMDKEEIEITTHFQRKRRVRDNVTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAVITYITRNQPEWFRNILSIAPIMFSNKMARLGKGYMFESKSMKLRTQISAEMLANIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHAGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHTPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVMMPAHGPAKNMEYDAVATTHSWVPKRNRSILNTSQRGILEDEQMYQRCCNLFERFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEDFTEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: FTHS_CHLSY
Sequence: MKTSLQIAAEARLEPIAAIAERLGLPVRYLEPYGRYRGKIDLTFLDDYHDRPLGRYVLVSAITPTPLGEGKTTTAIGLAMALNRIGKRAAVTLRQSSLGPVFGIKGGGAGGGYSQIVPLVESILHLNGDIHAVSQAHNQLAALTDNSWYHGNPLDIDPDRIEIRRVVDVNDRFLRQVMIGLGGKQNGFPRQTGFDISVASELMAILAMVNGVGARAALRDLRSRIGRMVVAFRRDGTPITAEDVRGAGAATVLMREALKPNLMQTIENTPALIHAGPFANIAQGNSSILADLIALRCADYVVTEAGFGVDIGAEKFFNLKCRASGLWPDVAVIVATIRALKAHSGKYDIVAGKPLPPALLHENPDDVISGGANLRRQIENLHQFKVPVIVALNAYPEDTPAEIDAVAHIATTAGAAGMAVSNVYAAGSAGGVDLARLVIEIAERPGPRPVQFLYPLEWSLADKITTIAHRIYGAAAVTFSPTAAAQLAALEDAGFGNLPICMAKTHLSLSHDPALRGAPEGFTFPIREVRLSAGAGFILPIAGTTVTMPGLGAHPAAHQIDIDDEGNIVGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: Y1962_ARCFU
Sequence: MPAKQAESDGLADRCKLRCRRSWGKCGLKLLHLLQPDPFNSCSVVDGIGADYLPPAVGSVKGVEDSETVVSDVYSRFERPLIVYSADRHNAREYLHDVETVSFGNESRWENNISFPTHHSFQSPQAASFRLSANPLQIPQTSFIIRF
What are the official names of this protein?
Uncharacterized protein AF_1962.
Protein: RCA_CUCSA
Sequence: MAATVSTIGAVNRTTLNNSNYGGLVPNSAFLGSRLKVSSRFTTSKMVTGNFKIVAEQDEEKQTEKDKWRGLAFDTSDDQQDITRGKGLADPLFQAPMGTGTHNAVLSSYEYISAGLRDYSYDNNVDGFYIAPAFMDKLTVHIVKNFLTLPNIKVPLILGVWGGKGQGKSFQCELVFAKMGINPIMMSAGELESGNAGEPAKLIRQRYREAADIIKKGKMCCLFINDLDAGAGRLGGTTQYTVNNQMVNATLMNIADNPTNVQLPGMYNKEENPRVPIIVTGNDFSTLYAPLIRDGRMDKFYWAPTREDRIGICTGIFRTDGVPFEDIVKLVDTFPGQSIDFFGALRARVYDDEVRKWAVGVGVERIGRNLVNSKESPPTFDQPKMTIEKLLEYGNMLVMEQENVKRVKLVTSI
What is the function of this protein?
Activation of RuBisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase; EC 4. 1. 1. 39) involves the ATP-dependent carboxylation of the epsilon-amino group of lysine leading to a carbamate structure.
What are the official names of this protein?
Ribulose bisphosphate carboxylase/oxygenase activase, chloroplastic, RA, RuBisCO activase.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO activase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: EFG_CHLTB
Sequence: MSDQEFGLDAIRNIGIMAHIDAGKTTTTERILFYAGRTHKIGEVHEGGATMDWMEQEQERGITITSAATTVFWLGAKINIIDTPGHVDFTIEVERSLRVLDGAVAVFDAVSGVEPQSETVWRQANKYGVPRIAFVNKMDRMGANYFGAVESMREKLGANAIPVHCPIGSESQFVGMVDLISQKALYFLEETLGAKWEEREIPEDLQEQCATLRMQLLEELATVDESNEAFMEKVLENPDSITEEEIHTVMRKGVIEGKINPVLCGSAFKNKGVQQLLDVIVKWLPSPLDRGNVRGINLKTGEEVSLKPSKDGPLAALAFKIMTDPYVGRITFIRIYSGTLKKGSAILNSTKDKKERISRLLEMHANERTDRDEFTVGDIGACVGLKFSVTGDTLCDENQEIVLERIEAPEPVIDMAIEPKSKGDREKLAQALSALSEEDPTFRVSTNEETGQTIISGMGELHLDILRDRMIREFRVEANVGKPQVSYKETITKTSNSETKYVKQSGGRGQYAHVCLEIEPNEPGKGNEVVSKIVGGVIPKEYIPAVIKGVEEGLNSGVLAGYGLVDVKVSIVFGSYHEVDSSEMAFKICGSMAVKEACRKALPVILEPIMKVTVITPEDHLGDVIGDLNRRRGKILGQESSRNMAQVSAEVPLSEMFGYMTSLRSLTSGRATSTMEPAFFAKVPQKIQEEIVKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_SHIFL
Sequence: MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRHELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGRRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1590_MYCTU
Sequence: MVEIVAGKQRAPVAAGVYNVYTGELADTATPTAARMGLEPPRFCAQCGRRMVVQVRPDGWWARCSRHGQVDSADLATQR
What are the official names of this protein?
Uncharacterized protein Rv1590.
What is the protein family that this protein belongs to?
To M.leprae ML1221.
Protein: JSPR1_BOVIN
Sequence: MATRAMEELDGGLGSCQVDEDLSALADPCPSRPQEDSVRATSRLADSSSRSHDSQERVTEGSPTGSVDTKPKKMEKEPVSKVTSGAGKEKLKAGATPRSPARKKAQTASPTQPPPPPALSDELPWGDLTLNKCLVLASLVALLGSAFQLCREAVARDVEAPAPVPESWASSSSSPKGPASTLPKPEAWAPSVRQPEPPSKLEERVQIPRSEEAAEKDEWESEEAADGEHVPLAGRGPKEKLKKEKPRKERPGKEKPQKEERPRKEKPRKEEKPRGAREPQGALPRRWEAREGGHRPWGRDSGAPEDRKRQAWVSLRRPDEEDRPLGRQKRRAGKGRD
What is the function of this protein?
Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S (By similarity).  EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels.  May regulate CACNA1S membrane targeting and activity.
What are the official names of this protein?
Junctional sarcoplasmic reticulum protein 1.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane. Endoplasmic reticulum membrane. Note=Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes.
Protein: Y577_MYCPN
Sequence: MQLANNKWRVFGTGWLIDWKKPKRTHNLSEPFYLYLATNLHIAVALSNPKDYAPFNKASIGNSLTTVFCLGKYINPQLFKLRTDVSNAFVSIQTSTIPKTAFVARDFVPLQNRGNQWVAPVRASEDDPALAKSYLDFAIIEVPLFLHNQMDKQIYDHFMRPAINTYERLGNSVGIFAYQPMASFKRDSYFALGYPQVESNIAALNLNQTEVKPTRPEDVAQVTFKEPWSVDHHREIPTLTTNQLTTIKTKHFSGSKLSWPFDHTKSFKIKNKWLGQNYQMYGHGLGIDQVNLRKGTSSSLVINQKRQIVGIYFATVITNPKKAVRNDVGLVQMLRFQGEGNSLNPN
What are the official names of this protein?
Uncharacterized protein MPN_577.
What is the protein family that this protein belongs to?
Belongs to the MG067/MG068/MG395 family.
Protein: DBP4_CRYNB
Sequence: MALGDKNQGSSKSQAKQKGTKGKNAQPRLKSNQLKRLKINEELKELQSRVDNFVPPSEITLFSELPMSSKTQKGLKSSHFLNPTPIQSLAIPPALQARDILGSAKTGSGKTLAFLIPLLERLYLEKWGPMDGLGAVVISPTRELAVQTFMQLRDIGKYHNFSAGLVIGGKPLKEEQERLGRMNILIATPGRLLQHLDSTVGFDSSAVKVLVLDEADRLLDLGFLPALKAIVSHFSPVQTAPGSRPSRQTLLFSATQSKDLAALAKLSLYEPLYISCNKPGEEGVMPANLEQYYAVVPLERKLDALWGFVKSHLKMKGIVFVTSGKQARRVRFIFETFRRLHPGLPLMHLHGKQKQPTRLDIFQRFSSSKSALLICTDVAARGLDFPAVDWVIQLDCPDDVDTYIHRVGRTARYQSAGTALTILCPSEEEGMKTRWGEKAIEVKRIKIKEGKMGNLKQSMQNFAFKEPEIKYLGQRAFISYMKSVHIQKDKSIFKIDALPAEAFAESMGLPGAPQIKLGNQKAAKVRGPSKEELARKAEKEEEEEEERAVVGSDEESEEDESEGLGSEDEEEEIDDEAEEIDDEEESGEESGSDEETEEEKDASKPKAPAVRTKYDRMFERKNQSILTPHYTALIAHDADNAAGAGEADDDDDVFTLARRDHNLSDDEEADTDAILGAEALAAELKKPLITSEDLSKRKLKAAASKKGLLKSRPGPEKVLFDEETGEAREFYKSGVDVEKEMSAADKRREYLEKEREIMKIQDKIDKEVAREKKKELKRKRKERERELRQMEMGDEPVAYLGGDDDYASADEGRSLSPSPAPSLEPERHAKKQRRGGVQESGAGDLEDEEALALRLLQGS
What is the function of this protein?
ATP-dependent RNA helicase required for ribosome biogenesis.  Involved in the release of U14 snoRNA in pre-ribosomal complexes.  Required for pre-rRNA cleavage at site A2 (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: Y2559_POLNA
Sequence: MLLTLPNLLSPADLLAARALLSAAPWADGRATAGIQAAQVKNNEQLPSDCEATRAIQAMVMKGLDGSPVFFSAALPKKMFPPRINRYGGDSNFYGNHVDNAIRAVPNSPQRVRTDISCTVFLNDPGDYDGGELTIADTYGEQRVKLPAGHAVLYPGTSLHQVRPVTRGHRLACFFWIESLVRGDDQRRLLYELDMNLLRLRERHGETAETTALTGTYHNLLRMWADT
What are the official names of this protein?
PKHD-type hydroxylase Pnap_2559.
Protein: PURR_ECOK1
Sequence: MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQSHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: MDM10_DEBHA
Sequence: MYTYMEYLQKCFYKTTNWNEDNIFSNITATSSALLEFPIPNGCKVDLSSKATEHSASSFTLSNYHSINGSLAYLYSSIPLRNTMGTKDISLQDAISGFKMLELNSSTTNALQNPVYKNTHDSLLYGRMYFPGSALEAMIIKRISPQTQLLIKCINNPHLDKNGTMIVYLQKNAPKLSREFIYSTNEALFGFRCLYNMGSSESNLNRSINNSNLIPKFDNSVISIGTEIWYAALSMSPGLSTAFRYSTRSTSTGKPLTMTFACNPILGHISSAYTVKTSVASTFCSKYDFNVFSYASNLSLGFEIYNYSSSNTSNSAATPPRIKNSDSQVLSNNSTDSKGTVHIRSPDVLDYKNHSNVIISPIQTFDNYYHINPTLLPSTKNEFEEVRPPPLESQVDSNNETAMTAFENLVNESDFSSVIKLSTSLNDKMLKLLWKGRCKDFLVTTGVKMILNPITNTPEFNRFGISFSYAC
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component MDM10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: SPT16_CANAL
Sequence: MSEVNIDAGLFYKRLSIFQKQLTANNIPQALIIVGARSDDNTYKKSTVLQNWLLGYEFIHTAIYITDKKCIFITSEGKSKHLKHLTNQKPDLVELWIRTKDVEHNKQLFIKLLETMTKLDSKYGKILKDKYDGKFIDEWNQILNDDNNNNNNNTTNDHALSAVDLAVTVSQALAVKDSEEFNNTKIASNASVVMMDTFVNDMMIIVDDEKKITNSQLTDQIEDKIENNKWYLKTKLGKNLLQSIKDFDPEYLEYCYSPIIQSGGDYDLKPSAVSTDKPLIGEGVILSSIGLRYKSYCSNIARTFLIDPTSEMETNYDFLLQLQKYIVDNLLKDGVPANKVYQDTIDYIKKERPDLVNHFTKNCGWLLGMEFRDSTFILNAKTTDRKLTTGQIISLTIGFNNLSNDKNDKNDKNDNKTNHQKNKQTYALLLTDTIKITDDSSILLTNYSKDRAAISFSFNDDNETQKENNNNNNKRPGLSQTSNTTALKLESTENTAILKSKLRHENTNADDANSEKLRQEIQIKLHEKRLQEGLARFSKADATDADDFKPIFKKYESYVRESQIPNSVNDLKIHIDYKNQTIILPISGRPVPFHINSYKSGSQNEEGDFTYLRLNFNSPGAGGNVTKKQELPYEDSPDNSFLRSITIRSRDRQRMVDVYKAIQDLKKDSVKREQEKKQMADVITQANLIELKGSRVKKLNNVFIRPTPDTKKIGGVLQIHENGLRYQSQPQSQSNFKNDQRVDVLFSNIKHLFFQPCKDELIVLIHCHLKNPIMIGKRKTFDVQFYREASDMAFDETGGRKRKYRYGDEDELQQEQEERRRKALLDKEFKGFAELIADSSHGMVDLDIPFRELGFQGVPFRSSVLCVPTRDCLVQLIDPPYLVVTLEEIEIAHLERVQFGLKNFDLVFVFKDFNKPVVHINTIPVELLEDVKSWLTDVDIPISEGQMNLNWVQIMKTVLADPYQFFIDGGWAFLTGQGESDEEEESDEESDFRVSDEDPQDEDEESDDYASEEESDDYSGSDDDGSGGGGDDDDDDSESGEDWDALERKAAKADRNSGFD
What is the function of this protein?
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.  It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
What are the official names of this protein?
FACT complex subunit SPT16, CaCDC68, Cell division control protein 68, Facilitates chromatin transcription complex subunit SPT16.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24 family. SPT16 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ZAR1L_HUMAN
Sequence: MERFVRVPYGLYQGYGSTVPLGQPGLSGHKQPDWRQNMGPPTFLARPGLLVPANAPDYCIDPYKRAQLKAILSQMNPSLSPRLCKPNTKEVGVQVSPRVDKAVQCSLGPRTLSSCSPWDGRDPQEPLPACGVTSPATGRRGLIRLRRDGDEAESKALPGPAEASQPQPPSRRSGADRQEEPGQLEESGEKDAPCPQETKSKQVPGDAASEPLRRPNFQFLEPKYGYFHCKDCKTRWESAYVWCISGTNKVYFKQLCCKCQKSFNPYRVEAIQCQTCSKSHCSCPQKKRHIDLRRPHRQELCGRCKDKRFSCGNIYSFKYVM
What is the function of this protein?
mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (By similarity).  Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity).  Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (By similarity).
What are the official names of this protein?
Protein ZAR1-like, Zygote arrest protein 1-like.
What is the protein family that this protein belongs to?
Belongs to the ZAR1 family.
Protein: DHB7_HUMAN
Sequence: MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
What is the function of this protein?
Does not have enzymatic activities toward E1 and DHT.
What are the official names of this protein?
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7, 17-beta-hydroxysteroid dehydrogenase 7, 17-beta-HSD 7, 3-keto-steroid reductase, Dihydrotestosterone oxidoreductase, Estradiol 17-beta-dehydrogenase 7, Short chain dehydrogenase/reductase family 37C member 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: HTP1_SAPPC
Sequence: MRIHHPLTLAALCVVLHESLGAAQHSNNVARLEHYRIAEIEHWEKRHLRSDSRGHRHHAHHGQVIDKENNNSQEQATTGNSVETNQVPSTEPTKDKTTPMKNALFKLFREKKLKTKNAGNGHAHDDDDDSDFSDDDVPTNAPTDAPTGAPTDAPTDAPTVAPTDAPTDAPTEAPTNAPTGTDAPTDAPTDAQVVPTFD
What is the function of this protein?
Effector involved in the disease saprolegniosis in salmonids and other freshwater fish, resulting in considerable economic losses in aquaculture (Probable).  Within the host fish cells, Htp1 is involved in the uptake of the S. parasitica effector Htp3 at a neutral pH (pH 7. 5) and its release from vesicles into host cytosol where it degrades nucleic acids (PubMed:29904064).
What are the official names of this protein?
RxLR effector protein Htp1, Host targeting protein 1.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell. Note=Host cell surface binding and uptake is mediated by an interaction with tyrosine-O-sulfate-modified cell surface molecules and not via phospholipids, as has been reported for RxLR-effectors from plant pathogenic oomycetes.