PharMolix/UniProtQA huggingface dataset:
Protein: PUR8_HAEIN
Sequence: MQLSTLTALSPLDGRYQDKVTPLRAIFSEFGLMKFRVAVEVRWLQKLASTADITEVPPFSTQANAFLDGIVANFNEADAARIKEIERTTNHDVKAVEYFLKEKIQNEVELVKVSEFIHFACTSEDINNLSHALMLSTARDEVILPEWQKLIDEITRLAEEYKTIPLLSRTHGQPASPSTVGKEMANVVYRLKRQFKQLQNAEILGKINGAVGNYNAHLSAYPNIDWHKFSEEFVTSLGIQWNPYTTQIEPHDYITEFFDAVVRFNTIIIDFDRDLWGYIALNHFKQRTIAGEIGSSTMPHKVNPIDFENSEGNLGLANAVMTHLGQKLPISRWQRDLTDSTVLRNLGVGLGYCLIAYASTRKGISKLEVNQPHLLEELNQNWEVLAEPIQTVMRRYGIEKPYEKLKELTRGKRVTEQAMREFIDKLDIPQEEKLRLQKLTPATYIGAAVELVEKLS
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: EREP1_MOUSE
Sequence: MILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAALRYLQIFASRRPCIDESQMSAEDVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQTDQEQESSFQMPEGPETAASPAEPVCTQITQGGALTNTTGEENTSGSTPILTLVQPPRSRRALPLLRTRSKSDPVLHHSEERATPVLSCEAATQTERRLDLATVTLRRGARPRASRCRPRSLIDYRSYIDTKLLVARFLEQSSCSMTPDIHELVENIKSVLKSDEGHMEEAITSASFLEQIMAPSQPSTSQAQELSWRRQPGLLHLRSCGDLSTFSLTARPRAERRPQQRAEAERPHSLIGVIRETVL
What is the function of this protein?
Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor.  Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway.
What are the official names of this protein?
Endosomal transmembrane epsin interactor 1.
What is the protein family that this protein belongs to?
Belongs to the ENTREP family.
Protein: FOLB_STRPY
Sequence: MDKIVLEGCRFYGYHGAYKEEQTLGQIFLVDLELSVDLQAASLSSQLTDTVHYGMVFDSVRQLVEGEKFILIDGLAGAICEQLFNEFPPIEAIKVAIKKENPPIAGHYKAVGIELERQR
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
What are the official names of this protein?
Dihydroneopterin aldolase, DHNA, 7,8-dihydroneopterin aldolase.
What is the protein family that this protein belongs to?
Belongs to the DHNA family.
Protein: RL30_CENSY
Sequence: MAGAYIVVRIKGQADVPHWAETTLKLLRLEKKHRATIIQSKENTRGMLDKVKHYVAWQEIDAGLAMELLTKRGRGPGYKKLTEKDLEGTDYPGIKELADALATGKASMSKIDRIKPWFALAPPRHGFKRSTKKMYGQKGVLGANRELSELVRSMI
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: TSAD_STRMU
Sequence: MIDRYILAIESSCDETSVAILKNEDQLLSNIIASQVESHKRFGGVVPEVASRHHVEVITLCIQDALQEAGITAGDLSAVAVTYGPGLVGALLVGMAAAKAFAWANHLPLIPVNHMAGHLMAAQSIADLQYPLLALLVSGGHTELVYVAAPGDYRIVGETRDDAVGEAYDKVGRVMGLTYPAGKEIDQLAHQGQDIYDFPRAMIKEDNLEFSFSGLKSAFINLHHNARQKGEQLRLEDLCASFQAAVLDILMVKTKKALAAYPVKTLVIAGGVAANQGLRERLKEDIKDINVVIPPLRLCGDNAGMIAYAAAVEYEKGHFAELDLNAKPSLAFEGLE
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLH4_CAEEL
Sequence: MSFSDDGWGAEAEVKVAEDVPEKNVPPPVEPPRAPQSTAIKTEPERNSDEPSAGFGIDPITTSKTFGSQTTPKTEFGGAPSLSGFGGNAAAAAANKTSFDQQGNGFGGAAKHGFGGVGGAPSSFGANVIPVNKPSLGHKTTGFGGEPKHVSGGAFSSANNFDQQDKGFGGAASSGFGNGSMLTNQKVGLENQTTGVGASEVPTSKPSSFGQQPAVVSGFGGAAKMGFGGSSSSGFGGQKAGATESSGFPTKETSTSQPGFGGDSSTGFGSGLKAGFGGHGAGAAENSGLPTETTGFGGKLPSAGFGASSSNESAFGQQSKGFGGATKNGFGGDSSSSFGSGSKAGFGGTSSSGIGGQKPGATESSGFPTKETSTSGGTFGSGFGGKPTSTGFGAPSTTDSSSGQQTAGFGGASKPGFGGDSSTGFGSGLKAGFGGHRASTAENSGLPTETTGFGGKLPPAGFGASSSNESAFGQQSKGFGGATKNGFGGDSSNSFGKRDSGFGGPQDQGFGDTDAPSKSGLGSFNTGGGAVKSAFGAAGFGSSSNFGNGNTFGEPSDNQRGNWDGGERPRGCHNCGEEGHISKECDKPKVPRFPCRNCEQLGHFASDCDQPRVPRGPCRNCGIEGHFAVDCDQPKVPRGPCRNCGQEGHFAKDCQNERVRMEPTEPCRRCAEEGHWGYECPTRPKDLQGNFLESYDFVFTPDDKMFEDAVNNDDKIDFDQKVVASTGKVEIPDMASFDGFKILPQDLHDNLKRMKMNRPTPIQRASFFPIMHGNDVVACAHTGSGKTLAFLIPFVIKLMEEFEKDRDVTDEKPSPRLLIVAPTRELVNQTFTTARQLTYETGLKCGLAFGGYSRNANVQHLRSFSQLNILVATMGRLQDFVNAGEVSLSKMKYIVLDEADRMVDSNDFGEEVSKIIGSPGERTQQTVLFSASFSEDLQSDDLPKFVKEGYTMLQVDKFGTANEKIDQKILPVPRTEKRDAIYKLLGIDENTVTLLPDAPIEKQKTLIFVNSVKFCDTLAALISSAGVSTISMHSYQNQEQRDRTLDDFRRGKYQCMVASNVCARGLNIAGLDHVVNYDMPDKNGFDEYVNRIGRTGRAGFTGTSTAFVDVENDTDIIPCLVSILNEAKKEVPEWLTEGAGHQEEGGDDWNEQEQEW
What is the function of this protein?
Probable ATP-binding RNA helicase.  May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos (PubMed:21402787, PubMed:24746798).  May protect somatic cells from excessive apoptosis during normal development (PubMed:27650246).
What are the official names of this protein?
ATP-dependent RNA helicase glh-4, Germline helicase 4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
Protein: TAUB_YERPS
Sequence: MLNVSGLWAEYQGKPALQDVSLQIASGQLVVVLGPSGCGKTTLLNLIAGFMTPSAGVITLDNIPVSGPSAERGVVFQNEGLLPWRDVVSNVEFGLQLAGMSKEQRRVTALKMLNRVGLAGFEHHFIWQLSGGMRQRVGIARALAVDPRLLLLDEPFGALDAFTREQMQELLLTIWRDTGKQILLITHDIEEAVFLASELLLLSPGPGQVVERLSLNFGQRYAEGEPCRAIKSDPEFIARREYVLGKVFQQREVLI
What is the function of this protein?
Part of the ABC transporter complex TauABC involved in taurine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Taurine import ATP-binding protein TauB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HFLX_THEKO
Sequence: MRAIGVIRNSRRERLSRAEFEELLRSAGYEVLAIVEQNREEHPRYNIGPGKLEELKELVKELKPDKVIFANRLTPSQAYNLWKELRIEIMDRWQLVLEIFEKRAHSKEAKLQVELASLQYEIPLVKEAIRRIRLGDRAGFKGMGEYQTQQYLKHIRYRMGKIRDELERVKADREVKRKKRENAGFVLVALAGYTNAGKSTLLNALADENVEAKNQMFTTLDTTTRRFRLGTKRILATDTVGFIDGLPPFIVEAFHSTLEEIVKADIVLLVLDSSEPWGEIRRKFLASLQVLRELKALEKPIIVALNKIDLIEEADAEEKVRLIWELARERGISLEDVVKISAREGRLEELMDALNRVVLKLPKYGAFRIIVKEPEKVPAVMALINSVGEVLSVEYGEKTRIDAYVQTGMVGEIKKMGAEIERLNHSGEGEELEQDEGYSDGG
What is the function of this protein?
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
What are the official names of this protein?
GTPase HflX, GTP-binding protein HflX.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=May associate with membranes.
Protein: IMG2_YEAST
Sequence: MISSCVTRCFGRGKCLPGPATASIYQTIRCISTNSNKAAEAPIFPKLEDVKMHELIGNNNFGKKTYYVERSRTGNLPVYSAYKNGGNKIITEIRKIEGDVIQLRNDLQEQLPFIPKKSWSVVMQSKKIIIKGNAVEAVKRVLTKKF
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
54S ribosomal protein IMG2, mitochondrial, Integrity of mitochondrial genome protein 2, Mitochondrial large ribosomal subunit protein mL49.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL49 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Protein: STAM2_RAT
Sequence: MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDRVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKAMKEEGVTFPSAGSQTVSAAAKNGASLNKNKEDEDIAKAIELSLQEQKQQYPETKALCPPAESQLSNKVARRVRALYDFEAVEDNELTFKHGEIITVLDDSDANWWEGENHRGAGLFPSSFVTTDLSTEVEAATVDKSNVIDDDVEEIKKSEPEPVYIDEGKMDRALQILQSIDPKDPKPDSQDLLDLEDICQQMGPMIDEKLEEIDRRHSELSELNVKVLEALELYNKLVNEAPMYSVYSKLHPAPYSATAAGVPVQTYPVQSHGGNYLGHGIHQVPVAQSYNLGPDPMGSSRSLPPNMNSVTAHTIQPPYLSTGQDAVSNPSYMTQSSHLQAAAGTAAYTPAMGVSADLSSFQSTASGLPQLAGFPVAVPVPPAPQPQASYHQQPLL
What is the function of this protein?
Involved in intracellular signal transduction mediated by cytokines and growth factors.  Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction.  May also play a role in T-cell development.  Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex).  The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
What are the official names of this protein?
Signal transducing adapter molecule 2, STAM-2.
What is the protein family that this protein belongs to?
Belongs to the STAM family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MOAA_PARMW
Sequence: MTPASALVDQRSRPLRVLRLSLTARCNLACPYCCPDLEDPPDLLSLEQQLRLIRVACRLGIHSLRLTGGEPLLSARLLPLLQAIAAARATPGDPLQGLQQVALTTNGTLLSDQRACDLRQAGLDRITVSLDGVDGAVVARMAGRPTATAGDSLARKVLGGLASARSAGFDPLAGELKLNAVIQRGVNEDQLLPLADLARDQGVELRLIEYMDVGNRNQWRLDQVLSAAEMVTRIRARWPLQAVGRPTGGTAQRWRYVDGGGHLGVIASISEPFCGDCNRLRVTADGQAFRCLFASVGTDLKPALHCEAELLRLVADLWRRRDDRYSDERQQTTGSMPHAEMAYLGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: MNHD2_STAEQ
Sequence: MSNLIILPMLLPFVCALILVFTKNKNRISKILSITTMIVNTMISIALLIYVVNHKPITLDFGGWKAPFGIQFLGDSLSLLMVSVSSFVVTLIMAYGFGRGEKRVNRFHLPTFILLLTVGVIGSFLTSDLFNLYVMFEIMLLASFVLVTLGQSVEQLRAAIVYVVLNILGSWLLLLGIGMLYKTVGTLNFSHLAMRLNHMENNQTITMISLVFLVAFSSKAALVIFMWLPKAYAVLNTELAALFAALMTKVGAYALIRFFTLLFDHHPSVTHTLLVFMACITMIIGAFGVIAYKDIKKIAAYQVILSIGFIILGLGSHTISGVNGAIFYLANDIIVKTLLFFVIGSLVYMSGYRNYQYLSGLAKREPFFGVAFVVVIFAIGGVPPFSGFPGKVLIFQGAITNGNYIGLALMIVTSLIAMYSLFRVMFIMYFGDADGEQVQFRPLPIYRKGLLSVLVVVVLAMGIAAPVVLKVTEDATNLNMKEDVFQKNVNTHLKEVNHK
What are the official names of this protein?
Putative antiporter subunit mnhD2, Mrp complex subunit D2, Putative NADH-ubiquinone oxidoreductase subunit mnhD2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURD_LIMRJ
Sequence: MKKIDEYQGKKVLVMGFGISGINAAHLLVKLGANVTANDKATPKNNDIVDDLEADGIKVITGDNPISLANEGFDVVVKNPGIPYDNPLVAAFVKQGTPIITEAELGWQIFDGHLVSVTGSNGKTTTTTLTQLMIAENAKHQVKYAGNIGISFSKIAEDLGPDDTLVTELSSFQLLGAPTIHPHIAIITNIFSNHLDYHKTRENYINAKLNITRNQTKDDFLVINWDRDEWQKIAQRSQATIVPFSRLNKSHEGSYVEDGMIYWRGQEVMPTKDIRLIGPQNVENALAAIAAAKLSGVTNDAIKKVLTTFSGVRHRLQYVMEYQERLFYNDSKSTDIEATEVALQGFDRPVILLAGGLDRGYTFERLVPYFKKHVKAMIVFGECKDKMKDAGNQAGVPVVESENAITAVPEAWKLSEPGDVILLSPANASWDQFPSFEVRGDKFIEAVEELTGKKEQ
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_ACIBT
Sequence: MHALEQKILTEGIVLSDQVLKVDAFLNHQIDPVLMQQIGKEFAARFKDAGITKIITIEASGIAPAIMAGLELGVPVIFARKYQSLTLKDDLYRAKVFSFTKQTESTIAISNKHINSSDKALVIDDFLANGQAALGLIDLIHQANAEVVGVGIVIEKSFQPGRDLLLEKGYRVESLARVQSLADGTVTFVKE
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_ZYMMO
Sequence: MAHFMKPSFSAMLIAVTVLAVSPLHARKKVTQPDPNFAATYPDDPRPEVVPNGAIFQPSYGYMPIISGARASHVGDMVTITLVESFAASKSANTTTSRSGGASIIPPTTGPLSFFKATDATASSSHNFKGTGTTGQSNSLSGEITATVARVFPDGTMLIRGEKIMTINRGDEHIRISGLVRPWDIDGTNHVLSTRIGDARISYTGTGDVARASRMGWLGHFFQMISPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane. Bacterial flagellum basal body.
Protein: RS27_THEVO
Sequence: MSEVKFVKPKNVSGHFLKIKCKDCGNVQVVFARPSSVVTCNICGATIAKPTGGVLETSGEVIESL
What are the official names of this protein?
30S ribosomal protein S27e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS27 family.
Protein: GLMU_PSEMY
Sequence: MSLDIVILAAGQGTRMRSALPKVLHPVANKPMLGHVIDTARSLQPQSIQVVIGHGADTVRERLAADDLNFVIQAEQLGTGHAVAQALPQLSAERVLILYGDVPLIETATLQRLLALVSDDQLGLLTVELADPTGYGRIVRDDSGVVQAIVEHKDASDAQRQIREGNTGILAVPGKRLADWLGRLSNSNAQGEYYLTDVIAMAVADGLTVATERAADEMEVLGANDRIQLAQLECHYQQRMARRLMAQGVTLRDPHRFDVRGQVSVGRDVTIDINVILEGKVVIEDDVQIGPNCVIKDSVLRKGAIVKANSHLDGAEMGEGADCGPFARLRPGSKLGAKAHVGNFVELKNAVMGEGAKAGHLSYLGDAEIGARSNIGAGTITCNYDGANKFRTVMGEDVFIGSNSALVAPVMLGDRATTGAGSVVTSDVPADTLAVGRAKQRNIEGWKRPTKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3BHS_VACCA
Sequence: MAVYAVTGGAGFLGRYIVKLLISADDVQEIRVIDIVEDPQPITSKVKVINYIQCDINDFDKVREALDGVNLIIHTAALVDVFGKYTDNEIMKVNYYGTQTILAACVDLGIKYLIYTSSMEAIGPNKHGDPFIGHEHTLYDISPGHVYAKSKRMAEQLVMKANNSVIMNGAKLYTCCLRPTGIYGEGDKLMKVFYEQCKQHGNIMYRTVDDNAVHSRVYVGNAAWMHVLAAKYIQYPGSEIKGNAYFCYDYSPSCSYDMFNLLLMKPLGIEQGSRIPRWMLKMYACKNDMKRILFRKPSLLNNYTLKISNTTFEVRTNNAELDFNYSPIFNVDVAFERTRKWLEESE
What is the function of this protein?
Catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids.  The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.  During viral infection, steroid production contributes to virulence by inhibiting the host inflammatory response.
What are the official names of this protein?
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase, 3-beta-HSD.
What is the protein family that this protein belongs to?
Belongs to the 3-beta-HSD family.
Protein: SYE_PECAS
Sequence: MKIKTRFAPSPTGYLHVGGARTALYSWLFARHQDGEFVLRIEDTDLERSTQDAIDAIMDGMNWLSLNWDEGPYYQTKRFDRYNAVIDQMLENGTAYKCYCSKERLEALREQQMEKGDKPRYDGHCRGSHEHHADNEPHVVRFLNPQEGSVIFNDRIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVIDDWDMEITHVIRGEDHINNTPRQINILKALGAPVPEYAHVSMILGDDGKKLSKRHGAVGVMQYRDDGYLPEALLNYLVRLGWSSGDQEIFSIDEMKSLFSLDAVNKSASAFNTEKLQWLNHHYINHLPAEYVATHLSWHIEQAGLDTRTGPQLSELVGLLGERCKTLKEMADSCRYFYEDFAEFDADAAKKHLRPVARQPLELVREKLAAITSWTAENIHHAIQGTADELGQGMGKVGMPLRVAVTGAGQSPGVDVTVHAIGQQRSLARIDKALAFIAERETQQ
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TLP1_GLECO
Sequence: AVFTVRNNXPYSIAPGVLTGGGAAASTTGFQLAPGXSXNVNVP
What are the official names of this protein?
Thaumatin-like protein 1, CTLP1.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
Protein: RL11_CORA7
Sequence: MAPKKKVTGLIKLQIEAGAANPAPPVGPALGAHGVNIMEFCKAYNAATESQRGNVVPVEITVYEDRSFDFKLKTPPAAKLLLKAAGIKKGSGVPHTDKVGSVTWDQCKEIAQTKFEDLNARDIENGARIIAGTARSMGITVDGVPAK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PX11B_CANBO
Sequence: MVYGELIYHPVVTKLLKFLDSSASREKLLRLLQYLCRFLTFYTFKRNFNIETIQLIKKIQSSIGISRKPLRFLKNLPHLKNLNKIYSNELLDSTLKIGDLIKNFGYALYFQFDTLQWLKLLGLLTSKNSGSLYFKIDKLAANFWLIGLTGSIITDLRNLKISYDSNKALLNEINSQNNNSNNDTLDEKLIEQNNDLILKNNEKINLNKRDLFKNILDSLIALKGSQLIDLNDGVLGFAGIITSIIGIEDIWNATKA
What is the function of this protein?
Involved in peroxisomal proliferation.  Could participate in peroxisomal elongation or fission.  May be involved in parceling of peroxisomes into regular quanta.
What are the official names of this protein?
Peroxisomal membrane protein PMP30B, Peroxin-11B, Peroxisomal membrane protein PMP32.
What is the protein family that this protein belongs to?
Belongs to the peroxin-11 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Peripheral membrane protein.
Protein: TRMD_SALRD
Sequence: MPGSIRIDIVTALPALVEEPLQHSILQRAQESDVATLQVHNLREYATDKHRQVDDRPFGGGAGMVLKPEPLFRAVEAIEGAAGEADDIIYLTPDGARLDQSMANRLSMEGHLILIAGHYKGIDQRVRDLLVTREVSIGDVVLSGGELPALMLVDAVVRLVPGALGDSSSALTDAFQDGLLGAPVYTRPAEFRGHEVPSVLRSGDHQAIARWRDEKRLEKTRDRRPDLLPDTNNDSTEASSQ
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GB_SHV21
Sequence: MVPNKHLLLIILSFSTACGQTTPTTAVEKNKTQAIYQEYFKYRVCSASTTGELFRFDLDRTCPSTEDKVHKEGILLVYKKNIVPYIFKVRRYKKITTSVRIFNGWTREGVAITNKWELSRAVPKYEIDIMDKTYQCHNCMQIEVNGMLNSYYDRDGNNKTVDLKPVDGLTGAITRYISQPKVFADPGWLWGTYRTRTTVNCEIVDMFARSADPYTYFVTALGDTVEVSPFCDVDNSCPNATDVLSVQIDLNHTVVDYGNRATSQQHKKRIFAHTLDYSVSWEAVNKSASVCSMVFWKSFQRAIQTEHDLTYHFIANEITAGFSTVKEPLANFTSDYNCLMTHINTTLEDKIARVNNTHTPNGTAEYYQTEGGMILVWQPLIAIELEEAMLEATTSPVTPSAPTSSSRSKRAIRSIRDVSAGSENNVFLSQIQYAYDKLRQSINNVLEELAITWCREQVRQTMVWYEIAKINPTSVMTAIYGKPVSRKALGDVISVTECINVDQSSVSIHKSLKTENNDICYSRPPVTFKFVNSSQLFKGQLGARNEILLSESLVENCHQNAETFFTAKNETYHFKNYVHVETLPVNNISTLDTFLALNLTFIENIDFKAVELYSSGERKLANVFDLETMFREYNYYAQSISGLRKDFDNSQRNNRDRIIQDFSEILADLGSIGKVIVNVASGAFSLFGGIVTGILNFIKNPLGGMFTFLLIGAVIILVILLVRRTNNMSQAPIRMIYPDVEKSKSTVTPMEPETIKQILLGMHNMQQEAYKKKEEQRAARPSIFRQAAETFLRKRSGYKQISTEDKIV
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: ASNA_DROGR
Sequence: MVDNLAPLEPSLQNLVDQESLKWIFVGGKGGVGKTTCSSSLAVQLAKVRESVLIISTDPAHNISDAFDQKFTKVPTKVNGFNNLFAMEIDPNAGLSELPEEYFDGENEALRVSKGVMQEMINALPGIDEAMSYAEVMKLVKGMNFSVVVFDTAPTGHTLRLIAFPQVVEKGLGKLLRLKMKLAPLLTQFVAMLGMADVNADTLSQKLDDMLRVITQVNEQFKNPDQTTFVCVCIAEFFSLYETERLVQELTKCGIDVHNIIVNQLLFLEKSHNSCSMCASRFKIQEKYLDQIADLYEDFHVTKLPLLEKEVRGPESIKAFSENLMIPFNPKETSNK
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase ASNA1 homolog, Arsenical pump-driving ATPase homolog, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: VAPB3_PYRFU
Sequence: MQIVEAIYEDGVLKLLKNLKLKEHSKVIIKVIDEEEIEKILDSRDY
What is the function of this protein?
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.  Its cognate toxin is VapC3 (Potential).
What are the official names of this protein?
Putative antitoxin VapB3.
What is the protein family that this protein belongs to?
Belongs to the UPF0165 family.