PharMolix/UniProtQA huggingface dataset:
Protein: LRP8_HUMAN
Sequence: MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP
What is the function of this protein?
(Microbial infection) Acts as a receptor for Semliki Forest virus.
What are the official names of this protein?
Low-density lipoprotein receptor-related protein 8, LRP-8, Apolipoprotein E receptor 2.
What is the protein family that this protein belongs to?
Belongs to the LDLR family.
Protein: RRF_ECO55
Sequence: MISDIRKDAEVRMDKCVEAFKTQISKIRTGRASPSLLDGIVVEYYGTPTPLRQLASVTVEDSRTLKINVFDRSMSPAVEKAIMASDLGLNPNSAGSDIRVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLKDKEISEDDDRRSQDDVQKLTDAAIKKIEAALADKEAELMQF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
Protein: RL30_MICLU
Sequence: MFESTRKNIQPSDATLVITQTRGVTGSKQNHRDTLRSLGLKRIGHQVTRKADAVTVGMVNTVPHLVSVEEVNNG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: TOP1_SCHPO
Sequence: MSSSDSDSVSLSIRRRQRRGSSKRISMKESDEESDSSENHPLSESLNKKSKSESDEDDIPIRKRRASSKKNMSNSSSKKRAKVMGNGGLKNGKKTAVVKEEEDFNEIAKPSPKHKRVSKANGSKNGAKSAVKKEESDTDDSVPLRAVSTVSLTPYKSELPSGASTTQNRSPNDEEDEDEDYKWWTSENIDDTQKWTTLEHNGVIFAPPYEPLPKNVKLIYDGNPVNLPPEAEEVAGFYAAMLETDHAKNPVFQDNFFRDFLKVCDECNFNHNIKEFSKCDFTQMFHHFEQKREEKKSMPKEQKKAIKQKKDEEEEKYKWCILDGRKEKVGNFRIEPPGLFRGRGSHPKTGSLKRRVYPEQITINIGEGVPVPEPLPGHQWAEVKHDNTVTWLATWHENINNNVKYVFLAAGSSLKGQSDLKKYEKSRKLKDYIDDIRKGYRKDLKSELTVERQRGTAMYLIDVFALRAGNEKGEDEADTVGCCSLRYEHVTLKPPRTVVFDFLGKDSIRYYNEVEVDPQVFKNLKIFKRPPKKEGDLIFDRLSTNSLNKYLTSLMDGLSAKVFRTYNASYTMAEELKKMPKNLTLADKILFYNRANRTVAILCNHQRSVTKNHDVQMERFAERIKALQYQRMRLRKMMLNLEPKLAKSKPELLAKEEGITDSWIVKHHETLYELEKEKIKKKFDRENEKLAAEDPKSVLPESELEVRLKAADELKKALDAELKSKKVDPGRSSMEQLEKRLNKLNERINVMRTQMIDKDENKTTALGTSKINYIDPRLTYSFSKREDVPIEKLFSKTIRDKFNWAADTPPDWKW
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  TThe free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
Protein: PBCC_EMENI
Sequence: MPESQIIELGTLGQIPLYSLERALQDPLRAVKLRRQIVSQHQATGNIDFTTDGSALPYEGYDYKAVLGACCENVIGYMPIPVGVAGPIKINGKMVFLPMSTTEGALVASTNRGCMAINAGGGVTALVLGDGMTRAPIVRFPSLEEAGAAKQWLGSDAGFLIIEDAFNASSRFARLQNIKATAVGSDLYIRFTASTGDAMGMNMISKGVEQALEAMQKHGFESMDVVSLSGNFCADKKPAAVNWIEGRGKTVTAQATIPEHAVRETLKTSVEALVELNVSKNLVGSAVAGALGGFNAHAANVVTAIYLATGQDPAQNVQSSNTLTVMKNVNGDLQISVFMPSIEVGTVGGGTVLGPQKAMLHMMGVQGADPEQPGRNAQELALLVAAGVLAGELSLCSALSAGSLVKSHLTHNRKKG
What is the function of this protein?
3-hydroxy-3-methylglutaryl coenzyme A reductase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) (PubMed:22506079, PubMed:27098256).  Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors (PubMed:22506079, PubMed:27098256).  The geranylgeranyl pyrophosphate (GGPP) synthase AN1592 is needed in the formation of GGPP, the precursor for diterpenes (PubMed:22506079, PubMed:27098256).  Lastly, the pimaradiene synthase pbcA performs the 2 cyclization steps that convert GGPP to ent-pimara-8(14),15-diene (PubMed:22506079, PubMed:27098256).  The putative roles of the remaining cluster enzymes in ent-pimara-8(14),15-diene biosynthesis is unclear (Probable).  The cytochrome P450 monooxygenase AN1598, the glutathione S-transferase AN1595, the oxidoreductases AN1596 and AN1597 probably function as decorative enzymes (Probable).  It is possible that in biological conditions the compound is oxidized to ent-pimara-8(14),15-dien-19-oic acid, which is a bioactive diterpene compound predominant in many plant extracts (Probable).
What are the official names of this protein?
3-hydroxy-3-methylglutaryl coenzyme A reductase AN1593, HMG-CoA reductase, Pimaradiene biosynthesis cluster protein AN1593.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ARC_BRAFD
Sequence: MKTYAEMTAELEQLAAHNDRLTAGLRSARAQIVELKSDLERVGDPPNSYATYLRRCEGTTIDVLHHGRRLRVATAASLDLDSLTPGAELRLNESLAAVEAVPPSDAGNVVPVVEALADSRLLVAVAPDDTRVLRRAGSLTTEQLHPGDHVLVDLKSQLVLERIDRAEITDLVLEQVPDVAFDQIGGLGEQIEAIRDAVELPFLQQDLYRTYGLRPPQGVLLYGPPGCGKTMIAKAVAHELVLRSAEVRGVSVAEALENSAFLNVKGPELLNKYVGETERSIRLVFERAREKAAADHPVVIFFDEMEALFRTRGTGLSSDVETTIVPQLLAEIDGVEGLDNVIVIGASNREDMIDPAILRPGRLDVKIRVRRPNLRAGREILGLYLDDAVPVREDREELLDLAAREIYDESPASAFVRVEYSDGGSDTLHFRDFVSGATLRNIVDRAKKLAVKDQLATGEVGVAAQHLRDAITTEFVENEDMPSAAHPEDWARVSGLPGGGRRRVDAVVPLQGRTLTTPDIAGTAAAGEDGATA
What are the official names of this protein?
AAA ATPase forming ring-shaped complexes, ARC.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: DNAJ_PORG3
Sequence: MAEKRDYYEVLGVSKNATDDELKKAYRKKAIQYHPDKNPGDKEAEEHFKEVAEAYDVLSDPEKRSRYDQFGHAGLGGAAGGGFSGGGMSMEDIFSRFGDLFGGFGGFGGFSDMGGSSRRRVRRGSDLRVRVKLSLADISKGVEKKVKVKKQVVCSKCRGDGTEEANGKTTCQTCHGTGVVTRVSNTFLGAMQTQSTCPTCHGEGEIITKPCSKCKGEGVEIGEEVISFHIPAGVAEGMQMSVNGKGNAAPRGGVNGDLIVVIAEEPDPNLIRNGNDLIYNLLISVPLAIKGGSVEVPTIDGRAKIRIEAGTQPGKMLRLRNKGLPSVNGYGTGDQLVNVNVYIPESIDAKDEQAIAAMENSDSFKPTDAARKDIDKKYREMLD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BR2_RANLT
Sequence: GLMSVLKKAGKHVAKNVAASLMDSLKCKITGGC
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Brevinin-2LT.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: CAMLG_RAT
Sequence: MEPMPSATDGGDRSATPSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEENQTKSKPLDSDILNPLGVPSVSKRVVLGDSVDGGVTDYQPSGGADIRGAQLGDKLDSFIKAPECSSKDGVELRQRNRGDLTADSAPRGSHHGLEQYLSRFEEAMKLRKQLISEKPSQEDGRTTEEFDSFRIFRLVGCALLALVVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKGEKKVKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHEVLEYWGPEVP
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287).  Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287).  Required for the stability of GET1 (By similarity).  Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (By similarity).  Essential for the survival of peripheral follicular B cells (By similarity).
What are the official names of this protein?
Guided entry of tail-anchored proteins factor CAMLG, Calcium signal-modulating cyclophilin ligand.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PROB_BACSU
Sequence: MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEMILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILLTRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIHADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLLATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPISGEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEEIMEAKGKRSDELDFEKTFEVIHRNDWVNVKD
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase 1, Gamma-glutamyl kinase 1, GK 1.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_SULSY
Sequence: MKCPKCGSLNDKVLETRQSKEGVVIKRRRECLNCGYRFTTYERIEEEHIEVIKKNNTVEPFNKEKIIRGILLASKNRPITQEQIKQIADDIEKYLLDEGKLKVSSAEIGDLVKNRLKELDPVSYLRFVSVFDGFEDIKDFEEFIKSFEKKI
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: CYB_CAPCU
Sequence: MTNIRKTHPLMKIVNNAFIDLPTPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTFLETWNIGVILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWVWGGFSVDKATLTRFFAFHFILPFIIAALAMVHLLFLHETGSNNPTGIPSDTDKIPFHPYYTIKDILGVMLLILVLMLLVLFTPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILVLVPFLHTSKQRSMMFRPISQCMFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLIILVMMPVASTIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MATN3_CHICK
Sequence: MRRALGTLGCCLALLLPLLPAARGVPHRHRRQPLGSGLGRHGAADTACKNRPLDLVFIIDSSRSVRPEEFEKVKIFLSKMIDTLDVGERTTRVAVMNYASTVKVEFPLRTYFDKASMKEAVSRIQPLSAGTMTGLAIQAAMDEVFTEEMGTRPANFNIPKVVIIVTDGRPQDQVENVAANARTAGIEIYAVGVGRADMQSLRIMASEPLDEHVFYVETYGVIEKLTSKFRETFCAANTCALGTHDCEQVCVSNDGSYLCDCYEGYTLNPDKRTCSAVDVCAPGRHECDQICVSNNGSYVCECFEGYTLNPDKKTCSAMDVCAPGRHDCAQVCRRNGGSYSCDCFEGFTLNPDKKTCSAVDVCAPGRHDCEQVCVRDDLFYTCDCYQGYVLNPDKKTCSRATTSSLVTDEEACKCEAIAALQDSVTSRLEALSTKLDEVSQKLQAYQDRQQVV
What is the function of this protein?
Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
What are the official names of this protein?
Matrilin-3.
What are the subcellular locations of this protein?
Secreted.
Protein: MIAB_SYNP2
Sequence: MTKPRQYHITTFGCQMNKADSERMAGILEEMGYHFTEDPYAADLVLYNTCTIRDNAEQKVYSYLGRQAKRKQEKPDLTLIVAGCVAQQEGESLLRRVPELDLIMGPQHANRLQDLLEQVEGGSQVVATEPIHIVEDITKPRRDSTVTAWVNVIYGCNEHCTYCVVPGVRGTEQSRYPEAIRAEMEELGRQGFKEVTLLGQNIDAYGRDLPGTTPEGRNKYTLTDLLYYVHDVPGIERIRFATSHPRYFTERLIKACQELPKVCEHFHIPFQSGDNEVLKAMRRGYTHEKYRRIINTIRSYMPDASISADAIVAFPGETEEQFENTLKLVDEIGFDQLNTAAYSPRPGTPAATWDNQLSEEVKGDRLQRLNHLVAQKAAERSQRYAGRIEEVLVEDQNPKNPSQVMGRTRGNRLTFFEGEINELKGKIVAVKITEARAFSLTGEAVEALVTA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_XANOR
Sequence: MNPAPNLVMVGPMGAGKSCIGRRLAERFGLEFVDVDQAIVEQVGSSIPAIFAQHGEAGFRQHEADTLQALLEQDNKLISTGGGTVLDPHNRQRICARGFVVHLHVSVPTQLTRLARDRNRPLLQRADREQLLHAMAAHRTPLYHEVADLSLETDHFSPAEATAQLVLRLAAQWRMSSAPA
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMSY_MOUSE
Sequence: MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAHKMNLSLYLGERPSYSMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVTANAVANAAVQHNASLPVPAETASKDGVSCSDEDEKPRKRRRTNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPKMSNIMQSIANSLPPHMSPVKITFTKPSTQTTNTTTQKVIIVTTSPSSTFVPNILSKSHNYAAVTKLVPTSVIASTTQKPPVVITASQASLVTSSSNGNSSSTSSPISSTVAVTTVVSSTPSVVMSTVAQGVSTSAIKVASTRLPSPKSLVSGPTQILAQFPKQHQQSPKQQLQQVQQQTQQPVAQPSSVSQQQQPQQSALPPGIKPTIQIKQESGVKIITQQVQPSKILPKPVTATLPTSSNSPIMVVSSNGAIMTTKLVTTPTGTQATYTRPTVSPSLGRVATTPGAATYVKTTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVVTTLLNAGGEKTLQTVPAGAKPAIITATRPITKMIVTQPKGIGSAVQPAAKIIPTKIVYGQQGKTQVLIKPKPVTFQATVVSEQTRQLVTETLQQASRVADASNSSAQEGKEEPQGYTDSSSSSTESSQSSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALLELQQTTVKEKLESKPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESELVAEYITTVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKSIPASSPGAITHIMQQALSSHTAFTKHSEELGTEEGEVEEMDTLDPQTGLFYRSALTQSQSTKQQKLSQPQLEQTQLQVKTLQCFQTKQKQTIHLQADQLQHKLTQMPQLSIRHQKLNPLQQEQAQPKPDAQHTQHTVVAKDRQLPTLMAQPPQTVVQVLAVKTTQQLPKLQQAPNQPKIYVQPQTPQSQMALPSSEKQPASQVEQPIITQGSSVTKITFEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTAVSDILQMSLMEAQIDTNVEHMVVDPPKKALATNVLTGEAGALPSTHVVVAGMTKCRESCSSPSAVGPPLTTRKIEAAGVPTTGQFMRIQNVGQKKAEESPTEIIIQAIPQYAIPCHSSSNVVVEPSGLLELNNFTSQQLDDDETAMEQDIDSSTEDGTEPSPSQSAVERS
What is the function of this protein?
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (By similarity).  Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (By similarity).  Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity).
What are the official names of this protein?
BRCA2-interacting transcriptional repressor EMSY.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
Protein: LEPA_PROMA
Sequence: MTDIPVARLRNFCIIAHIDHGKSTLADRLLQETGTVSSRDMQEQFLDNMDLERERGITIKLQAARMNYCASDGEQYVLNLIDTPGHVDFSYEVSRSLQACEGALLVVDASQGVEAQTLANVYLALENDLEIIPVLNKVDLPGADSERIKQEIESIIGLDTSTAIECSAKTGIGIPEILQSVVDRIPPPKDLLNDPTKALIFDSYYDSYRGVIVYFRVMTGSISRRDKILLMASRKSYELDEIGIMSPDQRKVEDLHAGEVGYLSASIKAVADARVGDTITLVDDSASEPLPGYTEAKPMVFCGLFPTDADQYPDLREALDKLQLSDAALKYEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYDLDLIVTAPSVIYQVNMIGGETLLIDNPATLPDPQKRESIEEPYVRIEIYAPNEYNGTLMGLCQDRRGDFVDMKFITTDRVTLIYEIPLAEVVTDFFDHMKSRTKGYASMEYHLIGYRENDLVRLDVLINAERADPLTTIVHREKAYGVGRGLVEKLKELIPKQQFKIPLQASIGSRIIASESISALRKDVLAKCYGGDISRKKKLLKKQAKGKKRMKSMGKVDVPQEAFMAVLKLNQ
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VL2_PAPVE
Sequence: MAPRRVKRANVYDLYRTCKQAGTCPPDVIPKVEGKTIADKILQYGSMGVYLGGLGIGTGSGKPGTGGYIPLRGGGSTTSLSSKPFAGGIPLETLEGIGAFRPGIVEDAGPALEGILPDAPAVVTPEAVPVDEGLSGLDISRELSQEQILSFLHPEGPDDIAVLEVRPTEHDQAHLLSTSTHPNPLFQGPVQQARIIAETSGAENVFVGGSGIGSNAGEDIELTLFAEPRTSTPEVPIKRSRGIFNWFSRRYYTQVPVEDPDEIAAAGSYVFENPVYDSKAFKPAQQPDITLQDEASVTGRDAARLLAGPSGRIGWSRITRPTSLGTRSGVRVGPLYHLRSSFSTIHSPETIELIPTVLEDDTEVLTGVPERDTGFDDVDLDSIASDSPLLPERHHLAFGARRSHIPIVARPGVQTGTVIDTRQMAENSVYVSDNGGQESQQTPTVVINGNINVSMEYFRHYYLHPSLLGRKRKRLFG
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: MED6_DROME
Sequence: MASRQMTNDHLRLSWHDTQMMATLSPQTVMDYFCRKSNPFYDHMCNNETVRMQRLGPEHLHNMIGLEYILLHVAEPILYVIRKQHRHNPSEATPIADYYIIGGTVYKAPDLANVINSRILNTVVNLQSAFEEASSYARYHPNKGYTWDFSSNKVFSDRSKSDKKDANSAKDENSGTLFQKQRVDMLLAELLRKFPPPIPPMLQNLQQPPPAGDDLNTARNASEMNNATGPLDIKTEGVDMKPPPEKKSK
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Required for activated transcription of the MtnA, MtnB and MtnD genes.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 6, Mediator complex subunit 6, dMED6.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: 3DHQ2_ASPFN
Sequence: MPSILLLNGPNLNLLGTREPHLYGTTTLNDVETVAKELAASYGAEVECLQSNHEGVLIDRIHEARGKSQAVVINPGAFTHTSVALRDALLGVGLPFIEVHITNVHARESFRHHSYLSDKAAAVIIGLGTFGYQVAVKHALENLVGLEERK
What is the function of this protein?
Is involved in the catabolism of quinate.  Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.
What are the official names of this protein?
Catabolic 3-dehydroquinase 2, cDHQase 2, 3-dehydroquinate dehydratase 2.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RL22_MYCA1
Sequence: MTTTEFPSAVAKARFVRVSPRKARRVIDLVRGRSVTDALDILRWAPQAASEPVAKVIASAAANAQNNNGLDPATLVVATVYADEGPTAKRIRPRAQGRAFRIRKRTSHITVVVESRPAKDQRSAKSSRTRRAEASKAAAKAPAKKAPAKKAPAKKAPAKTAAKKTPAKTSETSDAKGGSD
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: END4_VIBVU
Sequence: MTNSKNRFGNKFIGAHVSAAGGVDNAPLRAREIGANAFALFTKNQRQWVAKPLEEKTISAFKANCALLGFSPQQILPHDSYLINLGAPEAEKLEKSRLAFIDEMERCQLLGLNLLNFHPGSHLEKISEKACLSLIAESINLAHQAVPDVVAVIENTAGQGSNLGWRFEHLAEIIEQVEDKSRVGVCLDTCHTFAAGYDLRTPEACETTFAEFERVVGMHYLRAMHINDSKVKLASKVDRHHALGKGEIGWDCFEYIAKDSRFDSIPLILETIEPELWPQEIEQLRKYHLSSIA
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: IKBN1_MDBVW
Sequence: MEFSVRTIINNKVYINGENLLHAMCRHGNSLALSIIAQSINKNYQYLLNEYNREGRKCIHIAAVMHKGQVATELIIILLNFGADVNGRVLCTGDTVLHIAVYLKDYYLAEWLCRRSGININARNICRTHTISNSTEEKR
What is the function of this protein?
Suppresses the host immune response through NF-kappa-B inactivation.  Possesses ankyrin repeat domain required for NF-kappa-B binding but lack the regulatory regions required for dissociation from NF-kappa-B and degradation.  Therefore, prevents host NF-kappa-B release and subsequent activation (By similarity).
What are the official names of this protein?
I-Kappa-B like protein N1.
What is the protein family that this protein belongs to?
Belongs to the polydnaviridae I-Kappa-B-like protein family.