PharMolix/UniProtQA huggingface dataset:
Protein: FUCK_ECOLI
Sequence: MKQEVILVLDCGATNVRAIAVNRQGKIVARASTPNASDIAMENNTWHQWSLDAILQRFADCCRQINSELTECHIRGIAVTTFGVDGALVDKQGNLLYPIISWKCPRTAAVMDNIERLISAQRLQAISGVGAFSFNTLYKLVWLKENHPQLLERAHAWLFISSLINHRLTGEFTTDITMAGTSQMLDIQQRDFSPQILQATGIPRRLFPRLVEAGEQIGTLQNSAAAMLGLPVGIPVISAGHDTQFALFGAGAEQNEPVLSSGTWEILMVRSAQVDTSLLSQYAGSTCELDSQAGLYNPGMQWLASGVLEWVRKLFWTAETPWQMLIEEARLIAPGADGVKMQCDLLSCQNAGWQGVTLNTTRGHFYRAALEGLTAQLQRNLQMLEKIGHFKASELLLVGGGSRNTLWNQIKANMLDIPVKVLDDAETTVAGAALFGWYGVGEFNSPEEARAQIHYQYRYFYPQTEPEFIEEV
What is the function of this protein?
Catalyzes the phosphorylation of L-fuculose.  Can also phosphorylate, with lower efficiency, D-ribulose, D-xylulose and D-fructose.
What are the official names of this protein?
L-fuculokinase, L-fuculose kinase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RS8_CHLPB
Sequence: MPVTDSIADYITRIRNAGNASNKTTDIPYSRLKENLSRLLVEKGYIKSYTVITSEQFPFIRIDLKYTDSGKPAIKEITRVSKPGRRTYEGKDLKKYLGGLGLFILSTSRGVLTDKEAREQGIGGEVLFRIL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: GPDA_LEGPC
Sequence: MNKKTIAMLGAGSWGTAVAIHLAKIGHKTLLWSHNPQHVALMAEQHSNPAYLPGIPFPENLIPSDDLIECVQSADYVIIAVPSHAFAEITNKIPKPTQGLAWLTKGVDPASHQLLSQLVASRFGVDFPIAVISGPSFAKEVARFLPTALTLASNNTNYQKKMHQLFHHDNIRVYLSDDLIGVQLCGAVKNILAIACGISDGLGYGANAKAALITRGLAEMTRLGLSMGARQDTFLGLAGVGDLVLTCTDDQSRNRRFGLLLGREVPIPEAEHQIGQVVEGKHNAAQICAIANKNKVEMPICEQINALLHGIVHAQEAVNNLMSRPAKEE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_STAS1
Sequence: MRQTFMANESNIERKWYVIDAEGKTLGRLSSEVAAILRGKNKVTYTPHVDTGDYVIVINASKIHFTGNKERDKMYYRHSNHPGGIKSISAGELKANNPERLLENSIKGMLPSTRLGEKQGKKLFVYGGAEHPHTAQQPENYELRG
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ARNF_ENT38
Sequence: MMGYFWALMSVLLVSGAQLMMKWAMVSLPPVGQTDALMSAFMSVTPGAVALVIGLFAYVFSMGCWYMALRRIALSKAYPLLSLSYVLVWAAAIGLPWLHEPFSVGKLAGVSVIFVGLLLVCLPDKKS
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GME68_PESMI
Sequence: MAFMPPTPPKSLLGRHRLLAPSASVRVSPLCLGGMSIGNAWQGGMGECTKEMAFELLDTFYDLGGNFIDTANTYQGGESEQWIGEWMAKNNRRSEMVVSTKYTMSPKTGHPIQQSNFGGTGSKSLHLSIHNSLKALQTDYVDVLYVHCWDYATEIPELMHSLNVLINQGKVLYLGISDAPAWIVTKANMYARQNGLRPFSLYQGRYSAQERDLEREIIPMCQEEGMALQPFGVLGSGLFKSPDKPDTGARRMPPPMLIGREESLSKVLDAVAKRHNVPITSVALAYVLQKAPNVFPVLGGRKPEHLKANIEALSLELTAEDVQEIEKGYDFDIGFPHKFLGFGGMIRGPQDINILTMMGHFDYVAPKKAIRPHQGELTAPQGPA
What is the function of this protein?
Aryl-alcohol dehydrogenase; part of the gene cluster that mediates the biosynthesis of dibenzodioxocinones such as pestalotiollide B, a novel class of inhibitors against cholesterol ester transfer protein (CEPT) (PubMed:31474098).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS pks8/GME11356.  Pks8/GME11356 lacks a thioesterase (TE) domain, which is important to the cyclizing of the third ring of atrochrysone carboxylic acid, and the esterase GME11355 might play the role of TE and catalyzes the cyclization reaction of the C ring.  The lactamase-like protein GME11357 (or other beta-lactamases in Pestalotiopsis microspora) probably hydrolyzes the thioester bond between the ACP of pks8/GME11356 and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrates to form endocrocin anthrone.  Endocrocin anthrone is further converted to emodin via the endocrocin intermediate.  Emodin is then oxidized by several enzymes such as the Baeyer-Villiger oxidase GME11358, the oxidoreductase GME11367, the short chain dehydrogenase/reductase GME11373, as well as by other oxidoreductases from the cluster, to modify the A and C rings and open the B ring, and finally yield monodictyphenone.  The prenyltransferase GME11375 may catalyze the addition reaction between the C5 side chains and the carbon bone of dibenzodioxocinones.  The remaining biochemical reactions to the final product dibenzodioxocinones should be methylation catalyzed by methyltransferase GME11366 and reduction and lactonization reaction catalyzed by a series of oxidordeuctases (Probable).
What are the official names of this protein?
Aryl-alcohol dehydrogenase GME11368, Dibenzodioxocinones biosynthesis cluster protein GME11368.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Protein: NRL4B_TOBAC
Sequence: MALVPTPVVNEGPMFAEVDMGDNSSTPTVRATVVQASTIFYDTPATLDKAERLLAEAASYGAQLVVFPEAFIGGYPRGSTFGVSIGNRTAKGKEEFRKYHASAIDVPGPEVDRLAAMAGKYKVYLVMGVIERDGYTLYCTVLFFDSQGHYLGKHRKIMPTALERIIWGFGDGSTIPVYDTPLGKIGAAICWENRMPLLRTAMYAKGIEIYCAPTADSRDVWQASMTHIALEGGCFVLSANQFCRRKDYPPPPEYVFSGTEDLTPDSIVCAGGSVIISPSGAVLAGPNYEGEALISADLDLGEIARAKFDFDVVGHYARPEVLSLIVRDHAVSPVSFTSTSSKAESSPK
What is the function of this protein?
Highly specific for beta-cyano-L-alanine (Ala(CN)).  Low activity with 3-phenylpropionitrile (PPN).  Not associated with auxin production but may be involved in cyanide detoxification.
What are the official names of this protein?
Bifunctional nitrilase/nitrile hydratase NIT4B, TNIT4B, Cyanoalanine nitrilase B, Nitrilase 4B.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Protein: AMOB_NITEU
Sequence: MGIKNLYKRGVMGLYGVAYAVAALAMTVTLDVSTVAAHGERSQEPFLRMRTVQWYDIKWGPEVTKVNENAKITGKFHLAEDWPRAAAQPDFSFFNVGSPSPVFVRLSTKINGHPWFISGPLQIGRDYEFEVNLRARIPGRHHMHAMLNVKDAGPIAGPGAWMNITGSWDDFTNPLKLLTGETIDSETFNLSNGIFWHVVWMSIGIFWIGVFTARPMFLPRSRVLLAYGDDLLMDPMDKKITWVLAILTLALVWGGYRYTENKHPYTVPIQAGQSKVAALPVAPNPVSIVITDANYDVPGRALRVTMEVTNNGDIPVTFGEFTTAGIRFINSTGRKYLDPQYPRELIAVGLNFDDESAIQPGQTKELKMEAKDALWEIQRLMALLGDPESRFGGLLMSWDAEGNRHINSIAGPVIPVFTKL
What is the function of this protein?
Part of the ammonia monooxygenase complex, which catalyzes the oxidation of ammonia to hydroxylamine, the first reaction in the process of ammonia oxidation to nitrite.
What are the official names of this protein?
Ammonia monooxygenase beta subunit, AMO, Heterotrimeric Cu-heme enzyme.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Ammonia monooxygenase is active and distributed approximately equally in both subcellular fractions.
Protein: SYI_THEPX
Sequence: MDYNKTLNLPRTDFPMKANLPTREPEILKRWEEMDIYHKTLEKNKGKEKYILHDGPPYANGDIHIGTAMNKVLKDIIVKYKTMRGYDAPYVPGWDTHGLPIEQQAIKTLGIKRHEVSPTEFRKVCRDFAFSQIEKQKAQFKRLGVRGDWDNPYLTLNPEYEAKQIEVFGEMAKKGYIYKGLKPVYWCPSCETALAEAEIEYFDETSDSIYVKFRVKDDLGKFKGIVENLNNVYFVIWTTTTWTIPANLAIALNPEFDYALAKFGDEVYIMAKDMLDTVKKEANLSDYEIVAVFKGKDLEGMKATHPLYDRDSLIILGEHVTLEAGTGCVHTAPGHGEEDFLVGQEYGLEVLNPIDDKGYFTDKAPGYAGLYYEEANKVIKEDLKKANALVAETRITHSYPHCWRCKSPIIFRATEQWFASVEGFREEALKAIKEVNWYPSWGEERITNMVRDRRDWCISRQRVWGVPIPIFYCEKCGKPLINDDTINAVKKIFRQKGSDAWFEMSAEEILPKGITCECGSTKFRKETDIMDVWFDSGSSHAAVLQTHPDLKWPAELYLEGSDQHRGWFQSSLLTSVATRGKAPYRNVLTHGFVVDGEGRKMSKSLGNGIDPADVIKEYGADILRLWTVSADFTSDMRISQEILKQMTEAYRKIRNTSKFLLSNLYDFDPDKDMLPYEELLEIDKWALFRLNRVVEELTEAFDKYEYYDFLHLVHTFCVVDMSSLYLDILKDRLYTYPATSKERRAAQTTLYIILDTLVRLIAPVLTFTSEEIWSYMKHDSQNNFESVQLADWPQVQEKYNNPYIIEKWEKLFDIRKDISKALEIARTDKKIGHSLEAQVDIYPSQELYDFFKGFNDLEYVFIVSKVVLHQPEEPAPQNAYESDDYNLKIVVTHAPGEKCERCWMYSETVGTIKEHPTICARCASHIEQQTQV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_METCA
Sequence: MPVVTLPDGSRREFDHPVTLLQVAEAIGPGLAKAALAGRVDGRLVDLSHRIEADAEVALVTARDADGVEVIRHSTAHLLAQAVKALYPKAQVTIGPVIQDGFYYDFSYERPFTPEDLEAIEAKMHELAAQALPVERRTMPREEAIAYFRSLGEAYKAEIIEAIPRGEVISLYSQGDFTDLCRGPHVPDTGRLNAFKLMKIAGAYWRGDSRNEMLQRIYGTAWGDRKDLAAYLQRLEEAERRDHRKLGKALDLFHMQEEAPGMVFWHPKGWILWQEIEQYMRRVFRDNGYQEIRTPLVVARTLWERSGHWEKFSDEMFTTASEERDYAIKPMNCPCHVQVYNQGLKSYRDLPLRLAEFGSCHRNELSGALHGLMRVRGFTQDDAHIFCTEEQIQDEVSRFIDLLFKVYADFGFSEVQIKLSTRPEKRVGSDEVWDKAEHALETALNAKGLAWDLQPGEGAFYGPKIEFSLKDCLDRVWQCGTIQVDFSMPDRLGATYVAEDGARHVPVMLHRAILGSLERFVGILTEHYAGQYPLWLAPVQAVVLNITDRQADYAREVAQEFVSKGFRVIADLRNEKVGFKIREHSMQRVPYLLIVGDKEVEAGSVSLRTRDGKDHGSFGIGDLVAKFTEETMKRAVSH
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUFT_HUMAN
Sequence: TKPR
What are the official names of this protein?
Phagocytosis-stimulating peptide, Tuftsin.
Protein: MNMA_BURM1
Sequence: MSKRRVVVGMSGGVDSSVTAWLLKEQGYDVVGLFMKNWEDDDDGEYCSTRQDWIDVVSVADLIGIDVEAVNFAAEYKDRVFAEFLREYSAGRTPNPDVLCNAEIKFKAFLDHAMSLGAETIATGHYARVRERDGRFELLKAFDHTKDQSYFLHRLNQAQLSKTMFPLGEIPKTKVREIAAQIGLPNAKKKDSTGICFIGERPFRDFLNRYLPTKPGPMKTPDGKLVGEHIGLAFYTFGQRKGIGLGGSKDGSGEPWFVAAKDIASNTLYVVQGHDHPWLLSRELVAGNVSWVAGEPPAEGFACGAKTRYRQADAACTFARAGGERFSLAFADAQWAVTPGQSAVLYDGEICLGGGIIEFAATGQPGHAPAPAAAPALAEAR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCP_BACCR
Sequence: MKTVLLTGFDPFGGENINPAWEVAKGLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEELAPEIIICIGQAGGRPDITIERVAINIDDARIADNEGNQPVDVPVVEEGVIAYWSTLPMKAIVKKLREEGIPSSVSQTAGTFVCNHLFYGLMHELEKHDKKIKGGFIHIPFLPEQASNYPGQPSMSLSTIRKGIELAIEVTTTVKVDIVEVGGATH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTUB2_HUMAN
Sequence: MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHYNILYAADKH
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.  Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
What are the official names of this protein?
Ubiquitin thioesterase OTUB2, Deubiquitinating enzyme OTUB2, OTU domain-containing ubiquitin aldehyde-binding protein 2, Otubain-2, Ubiquitin-specific-processing protease OTUB2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C65 family.
Protein: PKHG5_HUMAN
Sequence: MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
What is the function of this protein?
Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity).  Involved in the control of neuronal cell differentiation (PubMed:11704860).  Plays a role in angiogenesis through regulation of endothelial cells chemotaxis.  Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631).
What are the official names of this protein?
Pleckstrin homology domain-containing family G member 5, PH domain-containing family G member 5, Guanine nucleotide exchange factor 720, GEF720.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Cell junction. Cell projection, lamellipodium. Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane. Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells.
Protein: KCNB2_MOUSE
Sequence: MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSVDDNHLSPSRWKWARKALSETSSNKSYENKYQEVSQNDSHEHLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEQPERPCVYEEEIEMEEVICPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTDEHQRARAPPFLTLSRDKGPAAREAAVDYAPIDITVNLDAGASHGPLQPDSASDSPKSSLKGSNPLKSRSLKVNFQENRASAPQTPPSTARPLPVTTADFPLTTPQHMSTILLEEALPQGQPPLLEADDSAHCQGPSKGFSPRFPKQKLFPFSSRERRSFTEIDTGEDEDFLDLQRSRPDKQADPSPNCLADKPGDARDSLREEGCVGSSSPQNTDHNCRQDIYQAVGEVKKDSSQEGYKMENHLFAPEIHSNPGDTGHCPTRETSM
What is the function of this protein?
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells.  Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.  Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization.  Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel.  Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes.  In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member.  Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
What are the official names of this protein?
Potassium voltage-gated channel subfamily B member 2, Voltage-gated potassium channel subunit Kv2.2.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Note=Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons.
Protein: RSXA_SHISS
Sequence: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLNLIYLRTLAFILVIAVVVQFTEMVVRKTSPVLYRLLGIFLPLITTNCAVLGVALLNINLGHNFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFNGLVKL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rsx electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NTPPB_XANC8
Sequence: MMPRLILASTSAYRRELLGRLHLDFDTARPEVDEHALPGETPQALATRLAGEKARAVAVRFPEAWVIGSDQVADLDGQALGKPGTLEQARAQLTRMSGRMVRFQTAVSLIGPDGFAAQALDLTDVQVRPLQPQEIERYLAAEPALECAGSFKCEGLGITLFDAIRSNDPTALVGLPLIAVARLLRQAGFSLP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_XYLFA
Sequence: MIDSTCYPRLSRIQIPEDLRTFQESELRAVADELRNYLIESVGLSGGHFAAGLGVVELTIALHYLYCTPIDHLVWDVGHQTYPHKILTGRRDKISTVKHQGGLAPFPKREESIYDTFGVGHSSTSISAALGMAIVAQRHGDERKVVAIIGDGAMTAGMAYEALNHAGGMSPAPNLLVILNDNRMSISEAVGGLTKMLGRATGSKALNAIREGGKRIFGDKKTNATARFLRRWEEHWKGMFVPSTLFEEMGFHYTGPIDGHDLPALLGALKTLRTLKGPQLLHVITTKGKGYELAEGDQIGYHAVAPFDPQKGLIKAGAKKQTYTDVFSEWLCDMAAVEPRLLAITPAMREGSGLVRFSQEYPQRYFDVAIAEQHAITLAAGMATQGAKPVVAIYSTFLQRGYDQLVHDVALQKLDVLFAVDRGGVVGPDGATHAGNLDLSFLRCVPNMMLMAPADEAECRKMLSTGFHYSGPVAVRYPRGTGPGVVPSAELDVLPVGVAQLRHSGTRIALLGFGVCVAPAEQVGRRLGLTVVNMRFIKPLDRTLLLELARTHEGFVTIEDNVVAGGAGSGVAELLNAEGIVLPIVHLGLPDAFQQHASREDLLAEAGIDAAGVYAALLSRWPDLAVQNHPLSAVS
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: NDK_RHIME
Sequence: MAIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKERPFFGELVEFMSSGPTVVQVLEGENAIAKNREVMGATNPANAAEGTIRKVHALSIGENSVHGSDAPETAAEEIAYWFSGTEIVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GHR1_ARATH
Sequence: MNLSRILLLSMFFLSAMGQLPSQDIMALLEFKKGIKHDPTGFVLNSWNDESIDFNGCPSSWNGIVCNGGNVAGVVLDNLGLTADADFSLFSNLTKLVKLSMSNNSLSGVLPNDLGSFKSLQFLDLSDNLFSSSLPKEIGRSVSLRNLSLSGNNFSGEIPESMGGLISLQSLDMSSNSLSGPLPKSLTRLNDLLYLNLSSNGFTGKMPRGFELISSLEVLDLHGNSIDGNLDGEFFLLTNASYVDISGNRLVTTSGKLLPGVSESIKHLNLSHNQLEGSLTSGFQLFQNLKVLDLSYNMLSGELPGFNYVYDLEVLKLSNNRFSGSLPNNLLKGDSLLLTTLDLSGNNLSGPVSSIMSTTLHTLDLSSNSLTGELPLLTGGCVLLDLSNNQFEGNLTRWSKWENIEYLDLSQNHFTGSFPDATPQLLRANHLNLSYNKLTGSLPERIPTHYPKLRVLDISSNSLEGPIPGALLSMPTLEEIHLQNNGMTGNIGPLPSSGSRIRLLDLSHNRFDGDLPGVFGSLTNLQVLNLAANNLSGSLPSSMNDIVSLSSLDVSQNHFTGPLPSNLSSNIMAFNVSYNDLSGTVPENLKNFPPPSFYPGNSKLVLPAGSPGSSASEASKNKSTNKLVKVVIIVSCAVALIILILVAILLFCICKSRRREERSITGKETNRRAQTIPSGSGGGMVVSAEDLVASRKGSSSEILSPDEKLAVATGFSPSKTSNLSWSPGSGDSFPADQQLARLDVRSPDRLVGELHFLDDSIKLTPEELSRAPAEVLGRSSHGTSYRATLDNGVFLTVKWLREGVAKQRKEFAKEVKKFSNIRHPNVVTLRGYYWGPTQHEKLILSDYISPGSLASFLYDRPGRKGPPLAWTQRLKIAVDVARGLNYLHFDRAVPHGNLKATNILLDGAELNARVADYCLHRLMTQAGTVEQILDAGILGYRAPELAASRKPLPSFKSDVYAFGVILLEILTGRCAGDVITGEQEGVDLTDWVRLRVAEGRGAECFDSVLTQEMGSDPVTEKGMKEVLGIALRCIRSVSERPGIKTIYEDLSSI
What is the function of this protein?
Receptor kinase acting as an early component in abscisic acid (ABA) signaling (PubMed:22730405).  Required for darkness, ABA, high CO(2) and hydrogen peroxide (H(2)O(2)) induction of S-type anion currents in guard cells leading to stomatal closure, possibly via the phosphorylation and activation of the anion channel SLAC1 and as a scaffolding component (PubMed:22730405, PubMed:27694184, PubMed:30361234).  Seems to act in parallel with SRK2E/OST1 in the ABA signaling pathway which regulates stomatal movement (PubMed:22730405).  Binds ATP (PubMed:30361234).  Involved in the local and/or systemic stomatal responses (e. g.  stomatal closure) to light stress (PubMed:29463779).
What are the official names of this protein?
LRR receptor-like serine/threonine-protein kinase GHR1, Protein GUARD CELL HYDROGEN PEROXIDE-RESISTANT 1, AtGHR1, Protein RADICAL-INDUCED CELL DEATH 7.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.