PharMolix/UniProtQA huggingface dataset:
Protein: REX_TREDE
Sequence: MAKQKVPAAPSVRRLPSYLHLVKKAEADKLEYISGTVIAEELELEPIQVRKDLTITGIVGKPKKGYPVKLLITAIEKFLGWNKEKKAFVIGAGSLGTALSGYQGFKEHGLDICAAFDSDKRKIGKEIHELPVFGMDELETKVKEYKPEIAILTVPSKYAQEAANAIVKAGIKAIWNFTNIKITVPDKVIVQKEDLSSGYAMLGVMMNTKK
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAEP_ECO55
Sequence: MEKYCELIRKRYAEIASGDLGYVPDALGCVLKVLNEMAADDALSEAVREKAAYAAANLLVSDYVNE
What are the official names of this protein?
UPF0253 protein YaeP.
What is the protein family that this protein belongs to?
Belongs to the UPF0253 family.
Protein: ARSC_SHIFL
Sequence: MSNITIYHNPACGTSRNTLEMIRNSGTEPTIIHYLETPPTRDELVKLIADMGISVRALLRKNVEPYEELGLAEDKFTDDRLIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLEILPDAQKGAFSKEDGEKVVDEAGKRLK
What is the function of this protein?
Involved in resistance to arsenate.  Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].
What are the official names of this protein?
Arsenate reductase, Arsenical pump modifier.
What is the protein family that this protein belongs to?
Belongs to the ArsC family.
Protein: HLAA_HUMAN
Sequence: MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
What is the function of this protein?
Allele A*74:01: Presents immunodominant HIV-1 epitopes derived from gag-pol (GQMVHQAISPR, QIYPGIKVR) and rev (RQIHSISER), carrying an aliphatic residue at position 2 and Arg anchor residue at the C-terminus.  May contribute to viral load control in chronic HIV-1 infection.
What are the official names of this protein?
HLA class I histocompatibility antigen, A alpha chain, Human leukocyte antigen A, HLA-A.
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: DNLI_PYRCJ
Sequence: MQFGELAKVLAAVESTTQRTTMVKLLTSLFKKAKPEEIDKIVYFILGDLRPPWEGVELGVAEKLCIRAISKATGLSAAELEGWYKKSGDVGEVARRALAAGKRPTLLAFAQQKPLEVAEVYDTLLKVAKAAGEGAQDLKVSLLSSLFSRASPEEAKYIARFVVGKLRLGVADMTLIEALSEAFGVSKEGLERAYHVYPDLGRLARHVAEGRPLEEIKITPGVPVLPMLAQRLSSASEILAKLGGTAICEYKYDGERAQIHLREGSVKIFSRRLEDITHAYPDVAKAVKEAVKAREAILEGEIVAVDPDTGEMLPFQELMHRKRKHDVAEAMEAYPAVLYLFDLLYVDGEDLTTQPLIYRRLRLSEVVEEGGDVYIAKWGMFDGAEDVDLFFHEAVSLGTEGLICKSPTSTYEMGARGWNWIKYKRDYRSEMIDTVDLVVVGAFHGRGKRAGLYGAFLLAAYDPSTDMFYTVCKVGSGFTDADLRRMYDMLQPLKIPHRHPRVVSKMQPDVWFVPQVVIEVIGAEITLSPLHTCCIGAVKPGVGLAIRFPRFTGRYRTDKRPEDATTTKELVEMYQRQKKVPTT
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: ORF28_HHV8P
Sequence: MSMTSPSPVTGGMVDGSVLVRMATKPPVIGLITVLFLLVIGACVYCCIRVFLAARLWRATPLGRATVAYQVLRTLGPQAGSHAPPTVGIATQEPYRTIYMPD
What are the official names of this protein?
Protein ORF28.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: SPD9_HUMAN
Sequence: MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVSGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS
What are the official names of this protein?
Putative speedy protein E9.
What is the protein family that this protein belongs to?
Belongs to the Speedy/Ringo family.
Protein: ARNE_YERPY
Sequence: MNSYLLLPMVSLLTCIGQLCQKQAAQCWEQPQARRLNLTLRWLAIAVVSLGLGMLLWLRLLQQLPLSVAYPMLSFNFVLVTLAAQLFYGEKATLRHWLGVAAIMFGILLMSWHL
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE, L-Ara4N-phosphoundecaprenol flippase subunit ArnE, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE.
What is the protein family that this protein belongs to?
Belongs to the ArnE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FOLD_PROM9
Sequence: MSLKLDGKKLSLEIEERLNDYIFINKKIAKRAPGLAVIRIGEDPASGVYVNNKEKACSRVGIKSFIFHLKDNVEQKEVEQLINKLNFDKNIDGMLLQLPIPKKFDEQRLISYINPSKDVDGLNEINIGKLVKNEPAMRSCTPAGIINLLRSQNITIEGKKIVVIGRSLLVGKPLSLMLLNLNGTVTMTHSKTLDLNKVCKEADILIAAAGKPNLIDSSFVKEGAVIIDVGIHRLKSSDKNKTRLCGDVLLEDVIPKVLAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSTLNDLLP
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL3_ENDTX
Sequence: MLKFIIGKKIGMTQVFDVKGNLMPVTVVEVGHCVVTDVRTVEKNGYSAVQLGFGEIKEKGLNKAQAVFFKRNNLSYKRTLKEFRVSEVAGFSVGHEIKADAFKAGDYVDVSAVTKGKGYAGVIKRHNFGMQPVSHGQSDRTRSRGSSGAQGPQKVLKGLKMSGHMGNEYVTVQKLLIVNVDAEKNVLLIKGSVPSANRGTLFISSTLKKIPKVLVAVVHKGTKVKKK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: MDH_BACP2
Sequence: MANKRKKVSVIGAGFTGATTAFLTAQKELADVVLVDIPQLENPTKGKALDMLEASPVQGFDANITGTSNYEDTAGSDVVVITAGIARKPGMSRDDLVSTNEKIMRSVTREIVKYSPEAIIVVLTNPVDAMTYAVYKESGLPKEKVIGQSGILDTARFRTFVAQELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGGGEIVNLLGNGSAYYAPAASLVEMVEAILKDQRRVMPTIAYLEGEYGYEGIYLGVPTIVGGNGLEQIIELELTEEERSQLDRSVESVKNVMKVLS
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: CASA1_MOUSE
Sequence: MKLLILTCLVAAAFAMPRLHSRNAVSSQTQQQHSSSEEIFKQPKYLNLNQEFVNNMNRQRALLTEQNDEIKVTMDAASEEQAMASAQEDSSISSSSEESEEAIPNITEQKNIANEDMLNQCTLEQLQRQFKYNQLLQKASLAKQASLFQQPSLVQQASLFQQPSLLQQASLFQQPSMAQQASLLQQLLLAQQPSLALQVSPAQQSSLVQQAFLAQQASLAQKHHPRLSQSYYPHMEQPYRMNAYSQVQMRHPMSVVDQALAQFSVQPFPQIFQYDAFPLWAYFPQDMQYLTPKAVLNTFKPIVSKDTEKTNVW
What is the function of this protein?
Important role in the capacity of milk to transport calcium phosphate.
What are the official names of this protein?
Alpha-S1-casein, Alpha-casein.
What is the protein family that this protein belongs to?
Belongs to the alpha-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEM3_PECAS
Sequence: MLANIIRIATRQSPLALWQARYVQQCLNHFYPDLHVELVPMVTRGDIILDTPLAKVGGKGLFVKELELALLEGRADIAVHSMKDVPVEFPDGLGLTTICERDDPRDAFVSNRYDSLEQLPEGSCVGTSSLRRQCQLRARRPDLVIRDLRGNVGTRLAKLDNGEYDAIILAVAGLKRLGLEERIRCALSPEESLPAVGQGAIGIECRLDDDRIRQLLAPLNHTDTAARVLAERAMNVRLEGGCQVPIGSYAELEGDTLWLRALVGAPDGSQMIVGERKGSVSDAEKIGVALAEELLAKGASAILQAVYQGQSSS
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: MTDH_APIGR
Sequence: MAKSSEIEHPVKAFGWAARDTTGLLSPFKFSRRATGEKDVRLKVLFCGVCHSDHHMIHNNWGFTTYPIVPGHEIVGVVTEVGSKVEKVKVGDNVGIGCLVGSCRSCESCCDNRESHCENTIDTYGSIYFDGTMTHGGYSDTMVADEHFILRWPKNLPLDSGAPLLCAGITTYSPLKYYGLDKPGTKIGVVGLGGLGHVAVKMAKAFGAQVTVIDISESKRKEALEKLGADSFLLNSDQEQMKGARSSLDGIIDTVPVNHPLAPLFDLLKPNGKLVMVGAPEKPFELPVFSLLKGRKLLGGTINGGIKETQEMLDFAAKHNITADVEVIPMDYVNTAMERLVKSDVRYRFVIDIANTMRTEESLGA
What is the function of this protein?
Oxidizes mannitol to mannose.  Provides the initial step by which translocated mannitol is committed to central metabolism and, by regulating mannitol pool size, is important in regulating salt tolerance at the cellular level.
What are the official names of this protein?
Mannitol dehydrogenase, NAD-dependent mannitol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T106C_RAT
Sequence: MGSQHSSALTFCQRKKDDNPEDLLAERDQEEAIAQFPYVEFTGRNSITCHTCQGAGYIPEEQVNKLVALIPHSDQRLRPQRTKQYVLLSVLLCLLASGLVFFFLFPHSVLVDDNGIRVSNVTFNKQDSLVVLDVTATLKIRNSNFYPVAVTNLFSQVQYMKAVVGSYTAANVSLIPPRSEHLVNFTVKAEVGGPSSYVYFYCTLPAILVHNIVIFMRTSVQISYIGHTSQSTLEAQHNVDCGENSTAVQSLLLVPWGPHL
What are the official names of this protein?
Transmembrane protein 106C.
What is the protein family that this protein belongs to?
Belongs to the TMEM106 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Lipid-anchor.
Protein: TRPD_PETMO
Sequence: MFNYYLQKVVKGENLSLDEMEQAMEMIMEGKVTHSQLSGFLVALHMKGETVEEITASAKVMKEKATPISIESGELMDTCGTGGDAKGTFNISTAVAFILAAAGVVVAKHGNRSVSSKSGSADVLESLGINISLPPSSVERCLKEINIAFLFAQDFHKATKHAAVPRKELGIRTIFNVLGPLTNPANIKYQLMGIYDPKLVYPIAEVLNNLGVKRAMVVHGSEGIDEFSLSGKNKVAFLNEGKIEKLEISPEDLGLEKYSIQEIQGGSAEENKRIILNIFNGEMGPKRDVVVLNTAAGLYVANKVNSLEEGINFAQEIIDSGKAMKKLEEMVEFTNFLSLQAKTS
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: Y1196_CLOPE
Sequence: MSENKFLPICKDDMIERGWEQCDFVLVTADAYIDHHSFGTAIISRVLENAGYKVGIIAQPDWKSVDDFKKLGRPRLGFLVNGGNMDPMVNHYTVSKKLRKKDLYTPKGEMGKRPDRATIVYCNKIREAYKDVNIVIGGIEASLRRFAHYDYWENKVRKSILVDSGADLLVYGMSEKQIVEVADFLNQGFDGKYIRHIPGTCYIADSLDEIYEEHIVLPSFKEVSSDKRTYAECFKIQYDEQDPVRGRTLVQEHNGKYVVINKPEMPLSREELDRVYALPYQKTYHPIYEKDGGIAAIEEVKFSLVSSRGCSGNCSFCAITFHQGRIVTSRSEDSIVEEAEEITKYDDFKGYIHDIGGPTANFRKPACKKQLTLGACKHKRCMSPGICKNMEVDHREYLHLLRRVRKLPGIKKVFIRSGLRYDYIMADKDDTFFKELVEHHVSGQLKVAPEHVSPNVLKYMGKPAGKTYDEFRRKFFRITERLGKKQFIIPYLMSSHPGCKLEDAIMLAEYLRDINYQPEQVQDFYPTPGTLSTTMFYTGLDPLTMEEVYIPRSKEEKAMQRALLQFKNPKNYNIVYDALVKAGREDLIGNGPKCLIRDKNSFGKGNNHSNHKSGGRKNRNENSGRRESEDKKRSSHSKKQRGNKSRGFDQKSQRGSKGKKRR
What are the official names of this protein?
UPF0313 protein CPE1196.
What is the protein family that this protein belongs to?
Belongs to the UPF0313 family.
Protein: CLPS_CHRVO
Sequence: MKVDMSTSVKDDAQLEASRVRENPPPMYKVLLLNDDFTPMDFVVQVLQQFFHMNREKATHIMLQVHTQGHGVCGVYTKDVAATKVEQVLQYAKAHQHPLQCVMEEN
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: UTP25_YEAS1
Sequence: MSDSSVREKNDNFRGYRKRGRQELRKIKRSSARTEGGSTETLEDVAEDIDHRSDEDEVSDVDSGDDFDIEDEEGKKEKVYDALLTILKSEHPEPKRRRREADESNKAPAEVGEDEHENTEHGPVDDQLEIENGLLGNHEDDNDDDSSEDEKDIDSEDEQDPFESHFNQVPEKFVDELSNAFKTKSVKYKSVKGSLSDSESYIYAKPVVIGEEALVESPYRSSSIYSYFLKQRLKVQNGLLDKKTDPLTALQKKLVDPMFQYKDILYEYDSYEKDEDEYRDLYALHVLNHIYKTRDRILKNNQRLQDNPDTEHLDQGFTRPKVLIVVPTREVAYRVVDKIISKSGIDQVDKKGKFYDQFRDDSLPPKSKPKSFQHIFRGNTNDFFVVGLKFTRKAIKLYSNFYQSDIIVCSPLGIQMILENTDKKKRQDDFLSSIELMVIDQLHSIEYQNISHIFTIFDHLNKIPDQQHEADFSRIRMWYINEQAKLFRQTMVFTKYISPAANSLINGRCRNMAGRWKNHKIIGSENSSIGQSGLKIRQIFQRFDIIGNSIIEEPDYRFKFFTSVIIPGIVKSTGYEDGILIYIPDYTDFIRIRNYMKEKTTILFGDINEYSSQRQLNANRSLFQQGRLKVMLYTERLHHYRRYEIKGVKSVVFYKPPNNPEFYNEVVRFIGKNAFLGNTDLNISTVRCIYSKLDGLSLERIVGTKRAAVLSHAQKEIYEFK
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: EF1B_SULAC
Sequence: MDVLVILKVFPESDEINLTQLSEEIKKRLPEGYRLVKNETEPIAYGLKALIAYIQMPENTEGGTDKLEELVNGIEGVSHAEVVNVTRLGF
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: PSPN_HUMAN
Sequence: MAVGKFLLGSLLLLSLQLGQGWGPDARGVPVADGEFSSEQVAKAGGTWLGTHRPLARLRRALSGPCQLWSLTLSVAELGLGYASEEKVIFRYCAGSCPRGARTQHGLALARLQGQGRAHGGPCCRPTRYTDVAFLDDRHRWQRLPQLSAAACGCGG
What is the function of this protein?
Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
What are the official names of this protein?
Persephin, PSP.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family. GDNF subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SAS1_BACCE
Sequence: MGKNNSGSRNEVLVRGAEQALDQMKYEIAQEFGVQLGADTTARSNGSVGGEITKRLVAMAEQQLGGRANR
What is the function of this protein?
SASP are bound to spore DNA.  They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation.  They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.
What are the official names of this protein?
Small, acid-soluble spore protein 1, SASP.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta-type SASP family.
Protein: CCSA_RANMC
Sequence: MIFFTLEHVLTHISLSIILIVITIFLMNLLVYEIEGLSYSSEKGMVASFLCITGLLVIRWIYSGHLPLSDLYESLMFLSWSFSIFYMIPYFRNKKSNLNVLTAPGTIFTQGFATSGVLREIHQSTILVPALQSQWLMMHVSMMVLSYAALLCGSLLSVALLVILFRKSSFTFSKYKGYYLPIGPLYFSEIQYVNEKKNIFLSFRNYHRYQLIQQLDCWSSRVISLGFLFLTIGILSGAVWANETWGSYWNWDPKETWAFITWTIFAIYLHTRTNKSLQSSNSAIVASIGFFIIWICYFGVNLLGIGLHSYGSFAIT
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: YL215_MIMIV
Sequence: MLFTYNKNPQYDSILMYAASNGYDKIVKLILDKVGTSFKEHIHETILLWAFQNEHYETIQLLIDHGFNKLVISNLLTNKNQFDVSNKYLIYFMADEEYYYQVRENIRNDQRVSTIKNTYRI
What are the official names of this protein?
Putative ankyrin repeat protein L215.
Protein: VP26C_MOUSE
Sequence: MGTTLDIKIKRANKVYHAGEMLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIDVLKPGKIPSGKTEVPFEFPLLVKGSKVLYETYHGVFVNIQYTLRCDMRRSLLAKDLTKTCEFIVHSAPQKGKLTPSPVDFTITPETLQNVKERASLPKFFIRGHLNSTNCAITQPLTGELVVEHSDAAIRSIELQLVRVETCGCAEGYARDATEIQNIQIADGDICRNLSVPLYMVFPRLFTCPTLETTNFKVEFEVNVVVLLHADHLITENFPLKLCRT
What is the function of this protein?
Acts as component of the retriever complex.  The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1).  The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes.  In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 26C, Down syndrome critical region protein 3 homolog, Down syndrome critical region protein A homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS26 family.
What are the subcellular locations of this protein?
Endosome.
Protein: Y2872_SINMW
Sequence: MNIDNDLRRIALQEQQLQFERFDLDTAWKLGVTLRRMAAERKLGCVIDITLFSMQVFYAALDGATPDNPNWVRRKRNTVFRLFKSSYATGLSLLKQQTNLQAKLGLADAEFAAHGGSFPIVVKGTGCIGAVTVSGLPQRDDHNLVVEALAELLGANHDELKLES
What are the official names of this protein?
UPF0303 protein Smed_2872.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: MRAY_CLOK5
Sequence: MYKLIYSVLIAFFIAMLEGPILIPLLHKFKFGQSIREDGPKTHLKKAGTPTMGGIIFILATFITMAVIVKKPSDEAMIALYAFIGFGIIGAIDDTLKIVRRKNLGLRAYQKMILLLAISGIFAYYSANNPYIGTSIIIPFKRDTWDLGVFYIPFIIVYFAATTNAVNLTDGLDGLATSVTLLVMTFLALVSFAMGHITLAVFCAILAGALLGFLKYNAFPAQIFMGDTGSLALGGAIGAVAMILKLPLLVIIIGGIYVLEALSVIFQVLSFKLTGKRIFKMAPIHHHFELSGWHETRVVSVFCIVTVILCLVGFLSL
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYA_FRAAA
Sequence: MDTAEIRSRFLNHFARRGHTIVPSASLVAQDPTLLLVNAGMVPFKPYFLGDLATPWPRATSVQKVVRTVDIENVGRTARHASFFQMCGNFSFGDYFKAEAIPFAFELLVDGFGFKPDDLWATVYLDDDEAEGIWRELLPAERIQRRGKEDNFWSMGVPGPCGPCSEIYFDRGAAYGREGGPIADEERYLEVWNLVFMQYERGEGAGYDYPILRELPARNIDTGMGLERMATILQGVDNLYEIDISRPVLDLAGQLTGRRYGADPADDVRLRVVADHSRTAAMLIADGVVPSNEGRGYVLRRLLRRAVRDARLLGAREPVMSELFGAIGTAMGPIYPELVDNAETITGVAVAEEASFAETLRTGTTIFDAAVRQVRSTGAATLGGDEAFKLHDTYGFPIDLTLEMAAEAGLSVDEAGFRRLMERQRQTAKADRAARRIGNVDLSAFRPILARSGATTFTGYEELSRESGVVGLVGIADGAGLTVVGEGDEVGVVLDATPFYAESGGQEPDFGLLRFDGGEVEVLDVQRPVPELVLHRVKVRSGELRLGDRVQAEVDENRRRAVSRSHTATHLVHAAFRRALGEGATQAGSLNSPGRLRFDFHALGAVPPSVLTDVEDEINEVALRDLPVRAFVTTQEEARRLGAMALFGEKYGDAVRVVDVGDYARELCGGTHVASSAQLGAVKLLSESSISAGTRRVEGLVGIDAFRYLAREHLLVSQLSTALKARPDELADRVTDIVGRLRDAERELDRLRAAAVLAGAGALAEGAEDVGGVAVVTAEVPAGTSPDDVRLLAMDVRGRLAGRPAVVAVVKADGSSIVVVTDSGARSAGLRAGELVRNSWASLGGKGGGKPDIAQGGGGNSEMIPAVFAKLRGLVAELASR
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPB_STAA1
Sequence: MNKQIQTEADELGFFGEYGGQYVPETLMPAIIELKKAYKEAKADPEFQRELEYYLSEYVGRATPLTYAASYTESLGGAKIYLKREDLNHTGAHKINNALGQALLAKRMGKKKLVAETGAGQHGVASATVAALFDMELVVFMGSEDIKRQQLNVFRMELLGAKVVAVEEGQGTLSDAVNKALQYWVSHVDDTHYLLGSALGPDPFPTIVRDFQSVIGKEIKSQILKKEGRLPDAIVACIGGGSNAIGTFYPFIKDDVALYGVEAAGQGEDTDKHALAIGKGSPGVLHGTKMYLIQDEGGQVQLAHSISAGLDYPGIGPEHSYYHDIGRVTFENASDTQAMNALINFTKHEGIIPAIESAHALSYVERLAPTMSKEDIIVVTISGRGDKDMETIRQYMAERGLAND
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: DEM_AGAAN
Sequence: KKIKRETEEDENENEEERNERSEMKRYAFGYPSGEEKKIKRETEEDENENEEERNEEGSEMKRYAFGYPSGEAKRMKRKPAEEETE
What is the function of this protein?
Dermorphin has a very potent opiate-like activity.  It has high affinity and selectivity for mu-type opioid receptors (By similarity).
What are the official names of this protein?
Dermorphin peptides.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermorphin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2353_STAES
Sequence: MLTKEFAQRVELSEKQVRKIVQHLEERGYHLSKTEYRGREATDFKEDDIELFTDIANKVKQTNSYDLAFEELEKEKDFLQVIVKDEDSQLPTDQNVAQLVEDLRSEIQKMREERQMLGQMINQVHQQQQELKELQTDITTKLDSNAQSLKSIQNSQEAIQSAQEQQSKDIAKANELKDSELRSHFDSMSNSASISQSNVASQSTTASLSQSESANDSMSSSLSESNSITSESNTNSKSEIESKSTSTSEFLSESGSVSNSEKSESISHSQSTSATPSSQSTYQQQPKEEKKGFFARLFNL
What are the official names of this protein?
Uncharacterized protein SE_2353.
Protein: SYE_VIBPA
Sequence: MTVKTRFAPSPTGYLHVGGARTALYSWLYAKNQGGEFVLRIEDTDLERNSQEAVDAILEGMEWLGLEWDEGPYYQTQRFDRYNEMVDKLLAEDKAYKCYASKELLDEIRAEQEANKEMPRYDANHPKIKAANEAAKDGDPCVIRFRNPKEGSVVFEDQIRGRIEIRNDQMDDLIIRRTDGSPTYNFCVVVDDWDMGITHVVRGEDHINNTPRQINIYEALGAPVPTFAHCAMILGDDGAKLSKRHGAVSVMQYRDMGYLPAALNNYLVRLGWSHGDQEIFSQEEMINLFSLNAVSKSASAFNTDKLQWLNNHYIKNSDPAYVAEHLQWHLDQQKLDVTNGPAITDVIKLVGERCHTLVELAEQIRYFYEDFSEFEAGAAKKHLRGVAKEPLEVALAKVEAITEWTTENLHQMIADVCAELEIGMGKIGMPLRVAVTGGGQSPSVDAVMALIGKERCVARIKMALEFIAEREANA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXGRX_BUNCN
Sequence: AKTGILDSDGPTVAGNSLSGT
What is the function of this protein?
Injection into mice produces severe neurotoxic effects such as circular movements, aggressive behavior, dyspnea, tonic-clonic convulsion and death.
What are the official names of this protein?
Granulitoxin, GRX.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: DDL_SOLUE
Sequence: MKLRVAVIYGGRTGEHEVSVRSAKSILAGLDCEKYETIEYFIDQNGKWSPGPILPEPGAHANIDVVFPVLHGTFGEDGTVQGLLELADLPYVGAGVLGSAVSMDKEMMKRVCKERMLPIVDYVTVTRQTPSIVDACRRLPFPMFVKPANLGSSVGISKAHDEQELEAAFSLAKQYDRKIIVERGIEGRELECSVLGNEAPMASLPCEILPSREFYDYEDKYLLDMARTQVPADLPGERTDEIRRLAVECYRAVECEGMARVDFFLEHGTNRLYINEINTIPGFTSISMYPKMWEHSGIPFCTLLDQLIEFALDRHRQKQVTRFAR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.