PharMolix/UniProtQA huggingface dataset:
Protein: ENV_HV197
Sequence: MRAREIQRNWQHLGKRGILFLGILIICSAANNLWVTVYYGVPVWKEATTTLFCASDAKAYETEVHNVWATHACVPTDPNPQEVVLENVTENFNMWKNNMVEQMHTDIISLWDESLKPCVKLTPLCVTLTCTNVTNNRTNANKNDTNINATVTSTDEIKNCSFNITTELKDKKKRVSALFYKLDIVQIKQSEINQSESEDRLINCNTSTVTQACPKVSFEPIPIHYCAPAGFAILKCNNNTCNGTGPCTNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSEDITKNTKNIIVQLNEAVEINCTRPSNNTRKSIHIGPGRAFYATGDIIGDIRQAHCNISGGQWNKTVNQVKKELGKHFNKTIIFQPSSGGDPQVTRHIFNCRGEFSYCDTTDTVDDTEEEEDTTITIPCRIKQIINMWQKVGQAIYAPPTAGNITCRSNITGMILTRDGGNDNNTRTEETFRPGGGDMRDNWRSELYKYKVVQIEPLGIAPTRARRRVVQREKRAVGIGALFLGFLGAAGSTMGAASITLTVQARQLLSGIVQQQNNLLRAIEAQQQMLQLTVWGIKQLRARVLAVERYLRDQQLLGIWGCSGKLICTTNVPWNSSWSNKSQSEIWENMTWMQWEKEISNHTSTIYRLIEESQIQQEKNEQDLLALDKWASLWNWFDISNWLWYIKIFIMIVGGLIGLRIVFTVLSVVNRVRQGYSPLSFQTLTPSPRGPDRPEGIEEGGGEQDKDRSVRLVSGFLALAWDDLRNLCLFSYRHLRDLVLIATRILDRGLKGSWEALKYLWNLILYWGQEIKNSAINLLNTTAIAVAEGTDRIIEIVYRAFRALLHIPRRIRQGFERLLL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: NDK_NITOC
Sequence: MVIERTLSIIKPDAVAKNIIGEIYTRFENAGLRIVAARMLHLSKEQAQEFYTVHKDRPFYNDLVGFMTSGPVMVQVLEGENAIARNREIMGATNPKEAVPGTIRADFAENIDANAVHGSDGSGTAEQEINFFFKSEDICPRIG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_BACC3
Sequence: MKRRTARERAMQALYQMDITGELEPKVAVENTLDEGEETNEFLESLVVGFVENKEVIDEAIRQNLKKWKLERISIVDRSILRVAVYEMKYMEEIPHNVTINEAIEIAKTFGDEESRRFINGVLSNIKDTL
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: FABZ_BUCAP
Sequence: MNSDEYIFNIKDILNILPHRYPFLLIDRILDFKAFQYLKALKNCTVNEPFFQGHFIKEPVFPGVLMIEAMSQAAAVLIFKSIGKLNINQLYYFVGIENTRFKKIVVPGDQIFIEVIYLKSKKNFIKFKIFAIVNKKNVCKSTIIFYKKNIFN
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SKI8_XENLA
Sequence: MSTQYSILFKQEHAHEDAIWSVGWGKNSNDGSELVISGSLDDLVKVWKWSDERLEMQWALEGHQLGVVSVDVSPSGNIMASSSLDAHIRLWDLESGKQIRSIDAGPVDAWSVAFSPDSQHLATGSHVGKVNIFGVETGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSTDSQLLVTASDDGYIKIYDVQHASLAATLSGHGSWVLNVAFSPDDAHFVSSSSDKSVKVWDVSARTCVHTFLDHQDQVWGVKYNRNGSKIVSVGDDQEIHVYDCPI
What are the official names of this protein?
SKI8 subunit of superkiller complex protein, WD repeat-containing protein 61.
Protein: RS15_MARN8
Sequence: MALSASEKAQIVKDFQQGDGDTGSPEVQVALLSANINKLQDHFKANKQDHHSRRGLIRMVNQRRKLLDYLKRKNADRYLELIQRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: LGT_LEGPH
Sequence: MLTYPNINPIAFSLGPLKVHWYGLMYLIGFVGAWLLGYWRIKHYKLNWNNDQLSDLIFYSALGVILGGRVGYMLFYDFQEFIHHPWVLFKIWEGGMSFHGGLLGVVIAAWLFCRKYGKTFLEVGDFVAPLVPLGLAAGRLGNFINGELWGRVTDVPWGMIYPHVDDQPRHPSQLYEFGLEGVALFILIWCYASKPRQQGRVSALFLMGYAICRLIAESFRQPDSQLGFVAFGWLTMGQVLSIPMLLIGIWLWWAKR
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATD3B_XENLA
Sequence: MSWLFGLNRGQPEPPGVPGFPEPPSPPGGSGDGGDKNRPKDKWSNFDPTGLERAAKAARELDQSRHAKEALNLAKVQEETLQMEQQAKIKEYEAAVEQIKNEQIRVQSEEKRKTLNEETKQHQARAQYQDKLARQRYEDQLRQQQLQNEENLRRQEESVQKQEAMRKATVEHEMELRHKNDMLRIEAEAHARAKVERENADIIREQIRLKAAEHRQTVLESIKTAGTVFGEGFRTFISDWDKVTATVAGLTLLAVGVYTAKNGTGVAGRYIEARLGKPSLVRDTSRITVVEAIKHPIKISKRIFSKIQDALEGVILSPRLEERVRDIAIATRNTKANKGLYRNILMYGPPGTGKTLFAKKLAMHSSMDYAIMTGGDVAPMGREGVTAMHKVFDWAGTSKRGLLLFVDEADAFLRKRSTEKISEDLRATLNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEIVHFDLPGLEERERLVRLYFDKYVLQPASEGKQRLKVAQFDYGKKCSELATLTEGMSGREISKLGVAWQAAAYASEDGILTEAMIDARVADAIRQHQQKMEWLKAEGKESTKEIGKNPLQPLLEGTPV
What is the function of this protein?
Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level.  May play an important role in mitochondrial protein synthesis.  May also participate in mitochondrial DNA replication.  May bind to mitochondrial DNA D-loops and contribute to nucleoid stability.  Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (By similarity).
What are the official names of this protein?
ATPase family AAA domain-containing protein 3-B.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids (By similarity).
Protein: RNE_GUITH
Sequence: MSFNIIILKELGFSLVFSQSKCEYIIFQKEQCGLNDIYFGFIPRQSIYPTLNAAFVTLDSERNQGFIPFTLLIKKSNQQFVIPNSVFLIQVIKEPTINKPATLTSHIFLNSFNLNLQFSGIDCKYLNLYPNIKFLHICLITLLIPSGLDINFDHSMKDILYLDLIGQSKILYYSFSNLFTKLLRIKKMPQFIFRNSNFFLPILNKLSLSSINDFFVSSYQRAVYLRHFLITHYFTIKQTDYRILFYPTAYKSMQLYYLDMLFYRSLKPIVYTLYGIFIVICKTEALISIDVNSGSHSSRVSQNLSLHTNLIASKSIIKEIKLRNLAGVIVIDFVDMIHQKDQIHLLAFFRYLLNINSVMITLIQLSDIGLLELTRKRQDQSIYDVFQIGNISKSSFLYDRILSLNKNLFKTNLLINYTLFSNVKLIYNY
What is the function of this protein?
Involved in intercistronic processing of primary transcripts from chloroplast operons.  The endonucleolytic activity of the enzyme depends on the number of phosphates at the 5' end, is inhibited by structured RNA, and preferentially cleaves A/U-rich sequences.
What are the official names of this protein?
Ribonuclease E/G-like protein, RNase E/G-like protein.
What is the protein family that this protein belongs to?
Belongs to the RNase E/G family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RDRP_I97A1
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGLFENSCLETMEVVQQTRMDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLTKKSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVHFVEALARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTVTGDNTKWNENQNPRIFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNESTRKKIEKIRPLLVEGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVGLKWELMDEDYQGRLCNPLNPFVSHKEVESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCTLFEKFFPSSSYRRPVGISSMMEAMVSRARIDARIDFESGRIKKEEFAEILKICSTIEELGRQGK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: FABZ_STRZP
Sequence: MIDIQGIKEALPHRYPMLLVDRVLEVSEDTIVAIKNVTINEPFFNGHFPQYPVMPGVLIMEALAQTAGVLELSKPENKGKLVFYAGMDKVKFKKQVVPGDQLVMTATFVKRRGTIAVVEAKAEVDGKLAASGILTFAIGN
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPL2_ARATH
Sequence: MEEAKHNEAEEAQGIEAREAKQIEAGETSRSSRKLITFEPKLVINKGISVLGFVLRLFAVFGTIGSALAMGTTHESVVSLSQLVLLKVKYSDLPTLMFFVVANAISGGYLVLSLPVSIFHIFSTQAKTSRIILLVVDTVMLALVSSGASAATATVYLAHEGNTTANWPPICQQFDGFCERISGSLIGSFCAVILLMLIVINSAISLSRH
What are the official names of this protein?
CASP-like protein 1A1, AtCASPL1A1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MDTC_YERPA
Sequence: MKFFALFIQRPVATTLLTLAITLSGIIGFSLLPVSPLPQVDYPVIMVSASMPGADPETMASSVATPLERALGRIAGVNEMTSTSSLGSTRIILQFDLNRDINGAARDVQAALNAAQSLLPSGMPSRPTYRKMNPSDAPIMIMTLTSDTFSQGQLYDYASTKLAQKIAQTEGVSDVTVGGSSLPAVRVELNPSALFNQGVSLDAVRQAISAANVRRPQGSVDAAETHWQVQANDEIKTAEGYRPLIVHYNNGSPVRLQDVANVIDSVQDVRNAGMSAGQPAVLLVISREPGANIIATVDRIRAELPALRASIPASIQLNIAQDRSPTIRASLDEVERSLVIAVALVILVVFIFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGVKPKVAALRGVREVGFTVLSMSISLVAVFIPLLLMAGLPGRLFREFAVTLSVAIGISLVISLTLTPMMCAWLLRSHPKGQQQRIRGFGKVLLAIQQGYGRSLNWALSHTRWVMVVLLSTIALNVWLYISIPKTFFPEQDTGRMMGFIQADQSISFQSMQQKLKDFMQIVGADPAVDSVTGFTGGSRTNSGSMFISLKPLSERQETAQQVITRLRGKLAKEPGANLFLSSVQDIRVGGRHSNAAYQFTLLADDLAALREWEPKVRAALAKLPQLADVNSDQQDKGAEMALTYDRETMARLGIDVSEANALLNNAFGQRQISTIYQPLNQYKVVMEVAPEYTQDVSSLDKMFVINSNGQSIPLSYFAKWQPANAPLAVNHQGLSAASTISFNLPDGGSLSEATAAVERAMTELGVPSTVRGAFAGTAQVFQETLKSQLWLIMAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFDAPFSLIALIGIMLLIGIVKKNAIMMVDFALDAQRNGNISAREAIFQASLLRFRPIIMTTLAALFGALPLVLSSGDGAELRQPLGITIVGGLVVSQLLTLYTTPVIYLYFDRLRNRFSKQPLMKLE
What are the official names of this protein?
Multidrug resistance protein MdtC, Multidrug transporter MdtC.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VG46_HAEIN
Sequence: MSDLALTWHNGEGDLVLGTESLLLDDSLTNAIIISLFTDLRVEGERGWWGDSYNDGFQTGSKLWTLSRAKQLPEILDDAQLYASQALQWLVDDGVAKSVQVIASNPQMSVLLLEILVVLPDGSTEQRTFRANWSL
What are the official names of this protein?
Mu-like prophage FluMu protein gp46.
What is the protein family that this protein belongs to?
To phage Mu protein gp46.
Protein: NINAG_DROME
Sequence: MGMKFQKILVLAGIVIGFLSIIVVLAGTLLKNSVPNVLAPVERHFAFDYVIVGGGTGGSTLTSLLAKNSNGSVLLIEAGGQFGLLSRIPLLTTFQQKGINDWSFLSVPQKHSSRGLIERRQCLPRGKGLGGSANLNYMLHFDGHGPDFDSWRDHHNLSDWSWAQMRSFMAAAKPKNPDMLEIPRRYSKLTEALEEAQAQFAYKDWIFRRSLYNIRNGLRHSVVQQFLNPVIHHSNLRLLPDALVKRIQLAPSPFLQATSILVGIKDEENREKEFSIELLMASGIGDVSALKKLGIPAQHSLPLVGHNLHDHFNLPLFVSMGVTGPTLNQNTLLNPMTLINYLSSGSGPLGNFGVLGNVVSYGGLGAPPYGITFFGAGAIDESALMSISNFKGPAFRALFPRYYNSSQEGFVVISSCLQPKSRGSVGLLNRHMRRNPLIDPNYLSSEEDVACTISAIRSAVELVNSTAFAALHPRIHWPRVQECSNFGPFERDFFDNRPSDQYLECLMRHVGLGSHHPGGTCALGSVVDSQLRLKGVSNVRVVDASVLPRPISGNPNSVVVAIALRAASWILKSELQAGDSK
What is the function of this protein?
Oxidoreductase involved in biosynthesis of 3-hydroxyretinal, a chromophore for rhodopsin Rh1.  Not responsible for the initial hydroxylation of the retinal ring but rather acts in a subsequent step in chromophore production.  May catalyze the conversion of (3R)-3-hydroxyretinol to the 3S enantiomer.
What are the official names of this protein?
Neither inactivation nor afterpotential protein G.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
What are the subcellular locations of this protein?
Secreted.
Protein: YE190_YEAST
Sequence: MMPAKLQLDVLRTLQSSARHGTQTLKNSNFLERFHKDRIVFCLPFFPALFFVPVQKVLQHLCLRFTQVAPYFIIQLFDLPSRHAENLAPLLASCRIQYTNCFSSSSNGQVPSIISLYLRVDLSPFYAKIFQISYRVPMIWLDVFQVFFVFLVISQHSLHS
What are the official names of this protein?
UPF0479 membrane protein YER190C-B.
What is the protein family that this protein belongs to?
Belongs to the UPF0479 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SP1_MOUSE
Sequence: MSDQDHSMDEVTAVVKIEKDVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIIPNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESSSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTPQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHQLPGLPLAIANTPGDHGTQLGLHGSGGDGIHDETAGGEGENSSDLQPQAGRRTRREACTCPYCKDSEGRASGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNGF
What is the function of this protein?
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli.  Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses.  Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation).  Binds also the PDGFR-alpha G-box promoter.  May have a role in modulating the cellular response to DNA damage.  Implicated in chromatin remodeling.  Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity).  Positively regulates the transcription of the core clock component BMAL1 (PubMed:24030830).  Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (PubMed:27918959).
What are the official names of this protein?
Transcription factor Sp1, Specificity protein 1.
What is the protein family that this protein belongs to?
Belongs to the Sp1 C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location (By similarity).
Protein: CCC11_ORYSJ
Sequence: MAANFWTSSHCKQLLDQEDVDKVPQADSDRGITLEEFRLVKIHMSFHIWRLAQQVKVRQRVIATAVTYFRRVYTRKSMTEYDPRLVAPTCLYLASKVEESTVQARLLVFYIKKMCASDEKYRFEIKDILEMEMKLLEALDYYLVVYHPYRPLLQLLQDAGITDLTQFAWGIVNDTYKMDLILIHPPYMIALACIYIASVLKDKDITLWFEELRVDMNIVKNISMEILDFYDTYKIDPQRGLPEDKIAPVMNKLPSKA
What are the official names of this protein?
Cyclin-C1-1, CycC1;1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
Protein: ENV_FSVST
Sequence: MEGPTHPKPSKDKTFSWDLMILVGVLLRLDVGMANPSPHQIYNVTWTITNLVTGTKANATSMLGTLTDAFPTMYFDLCDIIGNTWNPSDQEPFPGYGCDHPMRRWQQRNTPFYVCPGHANRKQCGGPQDGFCAVWGCETTGETYWRPTSSWDYITVKKGVTQGIYQCSGGGWCGPCYDKAVHSSITGASEGGRCNPLILQFTQKGRQTSWDGPKSWGLRLYRSGYDPIALFSVSRQVMTITPPQAMGPNLVLPDQKPPSRQSQIESRVTPHHSQGNGGTPGITLVNASIAPLSTPVTPASPKRIGTGNRLINLVQGTYLALNVTNPNKTKDCWLCLVSRPPYYEGIAVLGNYSNQTNPPPSCLSDPQHKLTISEVSGQGLCIGTVPKTHQALCKKTQKGHKGTHYLAAPSGTYWACNTGLIPCISMAVLNWTSDFCVLIELWPRVTYHQPEYVYTHFDKTVRLRREPISLTVALMLGGLTVGGIAAGVGTGTKALLETAQFRQLQMAMHTDIQALEESISALEKSLTSLSEVVL
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: OXLA_HUMAN
Sequence: MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQDPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGEGNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASYTWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQPPALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH
What is the function of this protein?
Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:17356132, PubMed:32818467, PubMed:32866000).  Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:17356132, PubMed:32818467, PubMed:32866000).  Also has weak L-arginine oxidase activity (PubMed:26673964).  Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:32818467, PubMed:32866000).  IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (PubMed:32818467, PubMed:32866000).  AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467).  Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells (PubMed:17356132, PubMed:25446972, PubMed:25778793, PubMed:28891065).  Also regulates M2 macrophage polarization by inhibiting T-cell activation (By similarity).  Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 (PubMed:23355881).
What are the official names of this protein?
L-amino-acid oxidase, LAAO, LAO, Interleukin-4-induced protein 1, IL4-induced protein 1, hIL4I1, Protein Fig-1, hFIG1.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted. Lysosome. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Secreted at the immunological synapse.