PharMolix/UniProtQA huggingface dataset:
Protein: AGRB_LISIN
Sequence: MSNFTAKVPLSERMADVLISKDRWKDDEEGYLKVKYGLEIILINVMKFAIVYGIALVTGLLLQTVTVHLSYLWLRRYSFGLHATKTLNCTLISLTMFVLAPFIFQNIPSNNWIVLGTFAFILLNMFLFAPADTESLPLIGEEHRKKLKRKAMIGTLILTGIALLIPFAEMKTLIMVGSLFQVISINPLTYKLLKRRYRNYEKYE
What is the function of this protein?
May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor.
What are the official names of this protein?
Putative AgrB-like protein.
What is the protein family that this protein belongs to?
Belongs to the AgrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPF_PROM1
Sequence: MTPLIFASEGFGLNLNIFETNIINLAVVVFGLYKFLPGFLGKILEKRRTTILSDLKEAEERLAQAQDSLSQAKDDLSSAKQKADKIRNDCKVRAEAIRLESEKRTVEEMARIKQGAASDLSAEAARVTSQLRKEAAELAIEKALAMLPKKLDSNTQDNFLKQSIKNIGDN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PYRE_THEVB
Sequence: MDESLADLRQELLALLCRDAYRAGDFTLSSGQKSQYYINCKPVTLSARGAYLVGRLFLEQLAPEAVAVAGLTLGADPLVVAVSVLSNLAGQDRAALIVRKEAKGHGTMSFIEGPPLPQGAVVTVLEDVITTGGSALKAVGRLQEAGYVVNEVLGIVDRQGGGAAAFAAQGIPLRSLFQISDLEAYLNRT
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: SYP_PROM2
Sequence: MRVTTSFPLGTLRDTPSEAEIISHQLLLQAGYIRRVNSGIYAYMPIMLRVIEKISAIIERELNSIGCTKLLLPQLHPADLWRKSERWEGYTAGEGIMFNLKDRQGKEFGLAPTHEEVITSIASETINSYKQLPQCFYQIQTKFRDEIRPRFGLMRSREFIMKDGYSFHSSEKDLASFYEKVGNAYENIFKSCGLETVGVEADSGAIGGASSKEFMVTADAGEDSILFTKSGSYAANIEKAVSLPSQPIPIKDNIAEWLETPHQKTILEVCDNNNLDPSQIIKVVIFLAQFEGEFEVPILACIRGDQHINEVKLFNLINKLHNFNLINLQKIEDKNTIEKNLVDFPLGFIGPDLDNKTIKASSNWVKKWTRIIDPSASELSKFISGGNKVNFHKLFQEFSFASKDYLIGDIRNAKKGDKISIANDEELKEKKGIEIGHIFQLGQKYSEKLNAKFSDKDGTLKNLWMGCYGIGVTRIAQAAIEQNHDQKGICWPIQISPFEVIIIPTNLKDPIQSELTEQIYNNFLINKIDVLLDDRNDRAGVKFKDAELIGIPFQIIIGRDSVNKEVELLSRTNNTKFKISTDKLLETFISESEIMYNKNS
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y012_MYCGE
Sequence: MKKINVVYNPAFNPISSKLNQTQLLKNASEELDIELKFFTSFDINTTKAKANLPFISNKILFMDKNIALARWLESNGFEVINSSIGINNADNKGLSHAIIAQYPFIKQIKTLLGPQNFDREWNPVMLDVFINQIKQSMEFPVIVKSVFGSFGDYVFLCLDEQKLRKTLMSFNQQAIVQKYITCSKGESVRVIVVNNKVIGALHTTNNSDFRSNLNKGAKAERFFLNKEQENLAVKISKVMQLFYCGIDFLFDQDRSLIFCEVNPNVQLTRSSMYLNTNLAIELLKAI
What are the official names of this protein?
Uncharacterized protein MG012.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: 249R_IIV6
Sequence: MKELIFFLLIIVILFVVFMVVSSKQTKTFGRNEEPFLQIKNNLGWGGCGLTNWF
What are the official names of this protein?
Uncharacterized protein 249R.
Protein: MED17_PICST
Sequence: MFSNGHFHIDLDPDAYGDANKDPFIQDEDKLTIAELIPRILIERNSFLNVTEESLQEEIDNPRAEDEANNEVDVASELDIGDESVENGSILMATLAETSLDPVELFQKQKLDLSKSINSALNETSLSLDFVSLLISSVKPNLAKSTISPHLNKSVPLGSLNSDRLSNENDDDDRNKSVAPKETPKVGHGWKLESLHKVTSLFREASENLNEQVLKERRYWNMINSVLTNDEVLFKTRDPLNNARAIGVKYGYGDSGSNFHDKGLAILRKDTVTGEISFNPINYAHKLTSKVFRYIRIKILSEIDGDFMLTGQSLFENDFSSSKDQIINDIEKARFFLFEEDLFYQLTREAKTLINYNVSIISNKIIIEINNEIIEIESVVYDENNDDELNNYYQNINAYSSINNGKCQLILKFFKIMLCCYYKYNLKLKQKIPTSLTKWKQSNSHPLVLRPLLGNIRHELNLKNMQSIIDRLIAKFKESLECKLQVDKFANLEHRSENPFQKSIERPVSKFNIVLKSKRSAYLKIDLELTTNEIFVNLIINMNVIKFKCEDDFKNNFNGVNVLQINFNDFHEIEECLDWTLLNFVNG
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 17, Mediator complex subunit 17.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 17 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUSB_NOCSJ
Sequence: MSARSKARKRALDVLFASDVRGEDAVAALDRAIAEGEGPTNDYTATLVRGVVEHQARIDELLSSYSHGWALDRMPAVDRNVLRLGVWELLYADDVPDAVAVSEAMALVTDLSTDESPQFVNGILGSIVRNKPSLA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: CLPX_ECO81
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRNHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVISHRVETGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIDGQSKPLLIYGKPEAQQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: Y1268_LIMRD
Sequence: MVVNIYDTANELSRQLRETQEYQGLQKAFEALKADGDTFDTFKKFQQAQADAQHKQMTGQQPTDDEIKNIQNLAKEVSGKKVVQDLMNQERQVDSMLQQLNKTITSPIQDLYSEVMPKMPGQE
What are the official names of this protein?
UPF0342 protein Lreu_1268.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: YS03_CAEEL
Sequence: MSVHLTEGRRIIQYTGFDDIDEEDVEPNEEAEGPGGVHKKRRGARKKNRRQRMEGLENVDQTVDLQLVTVPKVVPFRASRLLQEIYDRERVHGMRRDEARQLLEDKLLFLEEKSLENLHLRRFCLVVPSDEHFQLDDGSKIPSEIVSISMENGKISSILRVFPSKTRSFEMESVENFQSHRMRRVYWNPSIPKDSNSMFRTWNHFLDGCLLSLLLVPLNKLTQVLEFLRKINEMRTVINNRITVSICLSRVICVEDYLSAVQKVMNTRTVQLDHIPSMDLPSLHFALDFSRYHIQSMNTIFTGSTEMDKLSDENSSHELVEFSSWSCHREAHINMEPEKYHRILHWLWDLSPVNPVDEAE
What are the official names of this protein?
Uncharacterized protein ZK1128.3.
Protein: SPAT1_MOUSE
Sequence: MSLNPSRPSSSELVELHVFYVPEGSWNYKLNTISIEVINNFISAGFIRVSPQLTLQALRERLGEFLGVDAVAEKFLFLKCIGNNLAVVKEKQESELKLKSFAPPYALQPELYLLPVIDHLGNVYSASTVTLDEQESINDTTEINGTIYRPDSVSLSKDEPGNPSLLENTWRDFTNQEEAEESQPTQNHFGNSKLLGSLEESNDYFGNLKSPFLWKNDDEEEDEEKDNAALSRRQATLVCDKECTALPDLIDFPSFPSQRVSSRLTDTSLLKIEREKIIEQMKQVKEERKYLENIREELIKKVDKLFEQNKSKRYHASDSWKKKYLDTKKVTASLEEVLTKLREDLELYYKKLLMQLEAREIKMRPRNLANISDSKNYLIIQITEVQHAIDQLKRKLDTDKMKLILEVKMRKQAVSDLQTLKADLTQKKMGAPFRPPMFSGSVPT
What are the official names of this protein?
Spermatogenesis-associated protein 1.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome.
Protein: YRZT_BACSU
Sequence: MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISLPL
What are the official names of this protein?
Uncharacterized membrane protein YrzT.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: KYNB_CUPPJ
Sequence: MTNRPATPADSRKLWDISPPLSPATPVWPGDTPFQQETAWQMDEHCPVNVGRITLSPHTGAHADAPLHYAADGAPIGEVGLEPYLGRCRVIHCVGATPVVAPHHVEHALNDLPTRVLLRTYKRAPLDQWDTGFCAVAPETIALLAAHGVQLIGIDTPSLDPQESKTMDAHKAVRRHGLAILEGLVLDAVAEGDYELIALPLRFTGLDASPVRAVLRSLD
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: SNAC_STRPR
Sequence: MTGADDPARPAVGPQSFRDAMAQLASPVTVVTVLDAAGRRHGFTAGSVVSVSLDPPLVMVGIALTSSCHTAMAAAAEFCVSILGEDQRAVAKRCATHGADRFAGGEFAAWDGTGVPYLPDAKVVLRCRTTDVVRAGDHDLVLGTPVEIRTGDPAKPPLLWYRRDFHTPTPTTPALA
What is the function of this protein?
Provides the reduced form of flavin mononucleotide for the PIIA synthase reaction.
What are the official names of this protein?
NADH:riboflavin 5'-phosphate oxidoreductase, NADH:FMN oxidoreductase.
Protein: MNT_HUMAN
Sequence: MSIETLLEAARFLEWQAQQQQRAREEQERLRLEQEREQEQKKANSLARLAHTLPVEEPRMEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLPPPPPLPAAAQPLPLAPRQPALVGAPGLSIKEPAPLPSRPQVPTPAPLLPDSKATIPPNGSPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPHPHPHPHSVALPPAHLPVQQQQPQQKTPLPAPPPPPAAPAQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA
What is the function of this protein?
Binds DNA as a heterodimer with MAX and represses transcription.  Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
What are the official names of this protein?
Max-binding protein MNT, Class D basic helix-loop-helix protein 3, bHLHd3, Myc antagonist MNT, Protein ROX.
Protein: SECA_SODGM
Sequence: MLAKLLTKIFGSRNDRTLCRMSKAVDAINQMEPAMEQLSDEQLAAKTVEFRDCIAQGATVDSLLPEAFAVVREASKRVFGMRHFDVQLMGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALSGKGVHVVTVNDYLAQRDAENNRPLFEFLGLSVGINLPGLPAPAKRAAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSDMYRRVDKLIPHLIRQDKEDSESFQGEGHFSVDEKSRQVNLTERGLMLIEELLVKAGIMEEGESLYSPANIMLMHHVTAALRAHVLFARDVDYIVKDGEVIIVDEHTGRTMPGRRWSDGLHQAVEAKENVAIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTIVVPTNRPMIRKDLADLVYMTEKEKIDAIIEDIKTCTERGQPVLVGTISIEKSELVSGELEKAGIAHKVLNAKFHAMEADIVAQAGQPGAVTIATNMAGRGTDIVLGGSWQAEVAALESPDEQQIAAIKDAWQPRHEAVLAAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRCAIYTQRNELLDVADISETVKSIREDVLKTILDSYIPPQSLEEMWDVQGLEHRLKDDFDLDMPVAQWLDDEPGLHEEILRERVLEQMLAQYQRKEEIVGSDIMRNFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLESLKYEVISMLSKVQVRMPEEVEAMEQQRREEAERLARQQQLSHQAPVEELTQGSAAAAQEGRKVGRNDPCPCGSGKKFKHCHGKLQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CH38_DROME
Sequence: MTRSTYIWALAACLIACASANYGSSQGYGPESGSGASDGGADAASAAAAAAGGAGGAGGEYGGANAGAGALESGADAAGVAQAGQSSYGSDQNIPYKPVNTKGNTLTSSITYPQNKGEILIHRPAPIIVKRPPTKVLVNHPPLVVKPAPVVLHKPPAIVLRKVYVKHHPRRVKVEPVFVNVVKPPAEKYFVNENKQGYGQGSQSHGHGHGHGGHGHGHSGHGHGGHGAGPHGPGPHDGGRALPAYASGADSAAASAGYQLLQSGNQGLSALANIAGEREGPYGPAPSHQHYSAGPAGHGGYAAPAY
What are the official names of this protein?
Chorion protein S38.
Protein: METXS_BURO1
Sequence: MESIGIVAPQTMHFAEPLRLQSGSVLGNYQLVVETYGELNAARSNAVLVCHALNASHHVAGVYADDPRSTGWWDNMVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMSIDPSTGKPYGAKFPVVTVEDWVHAQARVADAFGIERFAAVMGGSLGGMQALAWSLMYPERVAHCIDIASTPKLSAQNIAFNEVARSAILSDPDFHGGDYYAHGVKPKRGLRVARMIGHITYLSDDDMAEKFGRALRRADGALDAYNFSFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFDGNLTAALAHTQAKYLIASFSTDWRFAPARSREIVKALLDNKRTVSYAEIDAPHGHDAFLLDDARYHNLLRAYYERIANEVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
Protein: YVAU_VACCC
Sequence: MIFFFISNWFRSLVCCGFSRCCTYCINAITSVCDGVCMIFYIISNWFRSRDFEYRRAIRIIYIIRFLRTSFW
What are the official names of this protein?
Uncharacterized 8.8 kDa protein.
Protein: ATL1_HUMAN
Sequence: MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCPARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKLIGGNRKLVARPLSPRSEEEVLAGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSRYDDLVSRLLEQGGWPGELLASWEAQDSAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDDILGNLSQQPEELRDLYSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKHVSGFSSSLRTSSTGDAGGGSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLLHCEAIGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDSVSIAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEVTWFRNKSKLGSPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGKA
What are the official names of this protein?
ADAMTS-like protein 1, ADAMTSL-1, Punctin-1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: FTO_RAT
Sequence: MKRVQTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLVFREAGSIPEELHKEVPEAFLTLHKHGCLFRDLVRIQGKDVLTPVSRILIGDPGCTYKYLNTRLFTVPWPVKGCTINYTEAEIAAACQTFLKLNDYLQVETIQALEELAIKEKANEDAVPLCMAEFPRAGVGPSCDDEVDLKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGSEDESDDESSFEGRDPDTWHVGFKISWDIETPGLTIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVLNDSDNGDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYKICTDWWCEPMTQLEGLWKKMESVTNAVLREVKREGLSVEQRSEILSAVLIPLTMRQNLRKEWHARCQARVVRTLPAQQKPDCRPYWEKDDPSMPLPFDLTDVVSEIRSQLLEARS
What is the function of this protein?
RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis.  Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes.  M6A demethylation by FTO affects mRNA expression and stability.  Also able to demethylate m6A in U6 small nuclear RNA (snRNA).  Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA.  Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping.  Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs.  Has no activity towards 1-methylguanine.  Has no detectable activity towards double-stranded DNA.  Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine.  Ability to repair alkylated DNA and RNA is however unsure in vivo.  Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation.  Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (By similarity).  Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity).
What are the official names of this protein?
Alpha-ketoglutarate-dependent dioxygenase FTO, Fat mass and obesity-associated protein, U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO, mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, m6A(m)-demethylase FTO, mRNA N(6)-methyladenosine demethylase FTO, tRNA N1-methyl adenine demethylase FTO.
What is the protein family that this protein belongs to?
Belongs to the fto family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Localizes mainly in the nucleus, where it is able to demethylate N(6)-methyladenosine (m6A) and N(6),2'- O-dimethyladenosine cap (m6A(m)) in U6 small nuclear RNA (snRNA), N(1)- methyladenine from tRNAs and internal m6A in mRNAs. In the cytoplasm, mediates demethylation of m6A and m6A(m) in mRNAs and N(1)- methyladenine from tRNAs.
Protein: RPOY_STRE4
Sequence: MIYKVFYQETKERSPRRENTQALYLDIDAASELEGRIKARKMVEEHTDYNVEFIELLSDKHLDYEKETGVFTLTEF
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: PSD13_BOVIN
Sequence: MKDVPGFLQQSQSSGPGQAAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALSFLEKTREKVKSSDEAVILCKTAIGALKLNIGDLQVTKETIEDVEEMLSNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCVDIKDLPVSEQQERAFTLGLAGLLGDGVFNFGELLMHPVLESLRDTDRQWLIDTLYAFNSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIARSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDILT
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 13, 26S proteasome regulatory subunit RPN9, 26S proteasome regulatory subunit S11, 26S proteasome regulatory subunit p40.5.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S11 family.
Protein: EXO2_BPR69
Sequence: MKSFKLNRVRYQNIMSVGGNPIDIQLDKVQKTLITGKNGGGKSTMLEAITFGLFGKPFRDVKKGQIINSTNKKELLVELWMEFDDKKYFIKRGQKPNIFEISVDGVRLDESASSRDFQEEFERSIGMSYASFKQIVVLGTAGYTPFMALSTPARRKLVEDLLEVGTLAEMDKINKSQVRELNSQGQVLDAKKDGVIQQIKIYNENIERQKKLSGDNVARLQNMYDDLAKEARSLKAEIEEANERLLNIVLDEDPTEAFNKIGQEAFLIKSKIDSYNKVIKMYHDGGTCPTCASQLHQGDPIVSKITDKLHECNHSFEQLTCHRDNLSVLVDEYRANVKTKQDLASDIRTKKQAMIATIDKAKKVKAAIEQASAEFIDHADEIALLQKELDKIIKTKSDIVLEKYHRGIITDMLKDSGIKGAIIKKYVPLFNKQINHYLKIMEADYVFSIDEEFNESIKSRGREEFSYASFSQGEKARIDIALLFTWRDIAEKVSGVRINTLIMDEVMDSATDSEGIKAISTILNSLTDANVFIISHRDHDPQAYGQHLQMSKVGRFTVMTVS
What is the function of this protein?
Exonuclease involved in phage DNA recombination, replication, and repair.
What are the official names of this protein?
Exonuclease subunit 2, Protein Gp46.
What is the protein family that this protein belongs to?
To phage T5 protein D13 and to yeast RAD52.
Protein: TGT_ALKCK
Sequence: MTAAITYEHIKTCKQSGARLGRVHTPHGTIETPMFMPVGTLATVKTMSPEDLKAMDAQIILSNTYHLWLRPGEEIIKEAGGLHQFMNWDKPILTDSGGFQVFSLSDLRKITEEGVHFRNHLSGEKLFLSPEKAMQIQHVLGSDIMMAFDECPPYPADHSYMKASVERTSRWAERCLAEHKRSGKDSVQGLFGIIQGGEYEDLRKQSANDLTALDFPGYAVGGLSVGEPKDVMNHVLEFTTPLMPEDKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIARNGTCMTSAGRLVVRNAKYARDFSPLDEKCDCHVCRTYSRAYIRHLIKCEETFGFRLTTYHNLYFLLNLMKQVRQAIMDDCLLDFREQFFEEYGFNKENARNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PYRF_ACTP2
Sequence: MDNKIIVALDYETEYEALSFVDQVDPSLCRVKVGKEMFTTLGTNFVKQLHERKFDVFLDLKYHDIPNTVARAVRSAADLGVWMVDLHASGGLTMMEEAKKILEPYGKDAPLLIAVTVLTSMEDLDLLQIGINASPMEQVIRLAHLAQRAGLDGVVCSPQEVEVLRTHCGKDFKLVTPGIRPEGSDVGDQRRIMTPKQAIETGSDYLVIGRPITQAQDPLSVLKSINASIR
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.