Protein: APMB_PENBR
Sequence: MLQVVPGSLDTAPCAFPTENLPGRGFQSIPLDLSSSGAIASEVLLRSWAVVLRYYVGSDMIAFGRIDDTDPASQFAVCHGDIPATATLEELKASSLSGNPNSLPLSEWIASNTFNTIVWNGTSFPLEKLETTSCSLALLVSDTPSLAFASHAIGENVAAAVAEGVAHVADIITNQPQTTIGAVDLFGAVSWSQLQEWNSTVPNMIEVCMHDLIDTQAKSRPDSTALDCWDGSVSYAQLVDYTSRLGSFLVTQNVGPEVFVPVCFDKSLWAVVSMIGVMKAGGAFVCIDPAQPVDRLETIISEVNAQVALGAPAYREALAGLVPNAIAIDADFILSLPPSTELPRVLPKDAAFAIFTSGSTGKPKGIVHEHRTMCSSARRHAAALNINSTTRTFQFAAYTFIVNTFELFTPLVEGGCVCVPSKEDRLGRTTGAMRDLNANWACLTPSFLRSIKPEDVPQLKTLLLAGEPVQQDNLDTWRHRVKMLNMYGASEASICVAGDLSGPVGRSTIGVGAGCTTWVVDPIDHDRLAPLGAIGELVIEGPILAREYIHQPEKTAEVFISNTPWMEEIRGALPSRAYKTGDLVRYGTDGRINLVGRKDMQIKLRGQRVELEEVEFHLRQLIPRGTEVAVGLVKPVDQPDRPMLAIFASLTKAFGENFSPVNEDLAADIESRMAGWKDKLGDSVPGYMVPSTVVKLNHMPLTASGKTNRKAIGDFACTLTIAALTGAAKKEHKEPATATGKVLRGIWADVLSLKEESISSDDSFLQLGGNSIDAMKLVNLTRDVQLGLSVAKIFTYPVLDEMADACTKVIVQSFEDVPFGLITGKTDSLIQEAALQCQVGPLAIEDLYPCTAMQEGLMALSDSREGAYVAQHSLSLGPSIDLNRFKKACQKVVDAHPILRTCIVYPEQSRALQAVVQGEIEWHTAEDLETYAKEDKARPMCAGQLLTRYGLVPDGEGWTFVWTVHHAVYDAWTLELTFDRLDKAYKGHPLERDTTFKEFIQHMVTTDESESDNFWREYLAGATRNEFPSAVSTSKQPVADSSVKYSMSLIRTDGLSGITVASMIRAAWGILIGSHSESDDVVFGGIVSGRNAPIANADKLFGPGIAAVPVRVKFPDNDTLTIREFIGDVQDQSTKMISFEQAGLQNIRRVSSDATAACDFQTLLVVQPHKEKHLSTEEIDLRAASEADANFGTYALTLECSLKSDGVVCSAHYDSSLVSKESVERILGQLENLLHQMCSSSADKKLNELIFISSKDQESIRGWNRHIPKPIHKTIHQMIAERIAERPDHEAVCSWDGSLTYAELDQHASRLARRLAQLDVQPESFVPCCFEKSTWAIPAMLGVLRAGGAFLNLDPSQPANRIQLMIRKLKSKTIVCSPSQYDLCRSMGEEYNIVVFDTQSPEESLPDMPPVDVKPENAAYVIFTSGSTGEPKGTIIQHGHYAIGSVTHAPAMLIDGNTRALQFASFTFDASLVETITILITGGCICVASEEQRKRDVAEAVRATRANWAALTPSFVNLLSPDDVPSIKVLILAGEAMSQSHIDTWGKRLRLVNGYGPSECCVASTSTIDVVPGVSPRNIGFTCSGASWVVMPTNHHRLMPVGSVGELVLEGWNVGRGYLDEPAKTEAAFVENPLWMDLGDEMRAPVVYKTGDLVRYNADGSLDFQRRKDTQVKLRGQRVELGEIEYRITQSLPNKPHAVVDIVCPKDAPDQPRLVAFIQVPASEARRKPTSIFMLNQPESMIPEPNERHVSSLSGLEDRLSDFLPMHMIPSAYIPVYHIPKMPSGKADRKTLIRIGSGLTHRRMAEYSGATEDARPPTTDMQITMQELWGETLKMPAAQINLNDNFLRLGGDSITAMRLASAARAKGIPLSTATIFQHPTLEAISAVAETLSHQQRPQSFEPFSTLKSIPKDQLIDDIIIPQLGVPAFQIQDALESTDFQSLAINGGLNQTRGWSNYLIFDFEGPIDLRRLQVACEQLVAHHAVLRTVFLSTGSELIQVILRSVAPEYSIHIQDEEDPTESLIREDLARPPHLGEAIVRFMLVKDDATHHRLIMRISHAQYDGSSMPHLMHDLRVAYRGEELPKRAQFSDFVRTQLHTSDGSKSFYKDMLSGSQMTSVVSHTKSSVTNVLNTMLAEMVPLVAFKDHGITAATVVKAAWALVLADMAATADVVYGHMVSGRNLPLDGVESMMGPCLNIVPVRANMNSMHTILDLLRHIQQQQTDTIPHESLGFQQIIDQCTDWTPATRFSSVFQYQDFGGEEAAPGQPVSFESVLKCTPGFVCPAPDACDMSLLATPVARVDLPRRPSPAGDTRDGPTAASDSPSRAR
What is the function of this protein?
Nonribosomal peptide synthase; part of the gene cluster that mediates the biosynthesis of asperphenamate, a rare linear amino acid ester that exhibits antitumor activity towards a number of cell lines (PubMed:29719714).  The structure of asperphenamate contains two subunits, N-benzoylphenylalanine and N-benzoylphenylalaninol, which are connected by an inter-molecular ester bond (PubMed:29719714).  The first step of asperphenamate biosynthesis is the generation of N-benzoylphenylalaninol by the nonribosomal peptide synthase apmA (PubMed:29719714).  Using phenylalanine and benzoic acid as substrates, apmA catalyzes amide bond formation and tethers the intermediate into the NRPS chain.  Then, the terminal R domain of apmA catalyzes the reduction reaction to get the shunt product N-benzoylphenylalaninol (PubMed:29719714).  Subsequently, the nonribosomal peptide synthase apmB activates the same substrates as does apmA (phenylalanine and benzoic acid) to produce N-benzoylphenylalanine before condensing N-benzoylphenylalanine and N-benzoylphenylalaninol to release asperphenamate (PubMed:29719714).
What are the official names of this protein?
Nonribosomal peptide synthase apmB, Asperphenamate biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.