PharMolix/UniProtQA huggingface dataset:
Protein: COX2_PERFA
Sequence: MAYPLQLGLQDATSPIMEELTSFHDHTLMIVFLISTLVLYIISLMLTTKLTHTSTMDAQEIETIWTILPAIILIMIALPSLRVLYMMDEINNPALTVKTMGHQWYWSYEYTDYEDLSFDSYMVNTTDLKPGDLRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVSSSRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFEAWSASM
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PANB_CALS8
Sequence: MNKVTTKTLFEKKQKGEKITMLTAYDYTFAKLFDSCMVDILLVGDSLGMVILGYDSTIPVTMEDMEHHVKAVARGTKYSMVVADMPFLSYHTTPEEAVRNAGRLIRAGAYAVKIEGCDDVIDKIEAVIKAQIPVMGHLGLTPQSVNVFGGYDLRAKEEKEAKKLIEDAKKLEEVGVFAIVLEKVPAMVAKQVQESVKVPIIGIGAGPYCDGQVLVCYDMLGMYEDFKPKFVKRYAEVGSIIKDAVSKYIDEVKRGEFPGKEHSY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANA_SHIDS
Sequence: MATNLRGVMAALLTPFDQQQALDKASLRRLVQFNIQQGIDGLYVGGSTGEAFVQSLSEREQVLEIVAEEAKGKIKLIAHVGCVSTAESQQLAASAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALKQTSGDLYQMEQIRREHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALKEGDIQTAQKLQTECNKVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFGPVDEKYLPELKALAQQLMQERG
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_CLOBM
Sequence: MKKEEIIQAIKEMTVLELNELVEACEEEFGVSAAAPVAVAGAGAAAAGAAEEKTEFDVVLADAGSEKIKVIKAVREVTGLGLKEAKALVDGAPKTLKEAASKEDGEAIKAKLEEVGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RL1_MANSM
Sequence: MAKLTKRMKAIKAGVDSTKAYEINEAIAVLKQFATAKFDESVDVAVNLGIDPRKSDQNVRGATVLPNGTGRSVRVAVFTQGANADAAKEAGADLVGMEDLAEQIKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVADAVKNAKSGQVRYRNDKNGIIHTTIGKASFSAEALTQNLQALLAALVKAKPTTAKGIFIKKVSISTTMGAGVAVDQNSL
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: ISPD_BLOPB
Sequence: MLKKKIPYITAILPAAGTGKRMKSLLPKQYCTIGDKTLIEHSMNALLCQSCIRHCIVVINARDHWFRQLSISYDPRVSVVVGGHTRADSVMAGLQHVKKSVWVIVHDAVRPCLHHEDLLRLFEITKFSQVGGILAIPICNTIKRTYCGTNFIRYTVNRENLWHALTPQLFNYDLLKYCLKKALKNRVTVTDEASALEYCGYKSIVIHGRSDNIKVTHQNDLKLANFYLSKLYKKT
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: MNMC_PSEPW
Sequence: MPASTLLQHAQIDWDDQGRPHSRQYGDVYFAINEGIAETQHVFLEQTRLRQRFANLAPHGCLVIGETGFGTGMNFFCAWQLFAETAHADARLHFVSVEKYPLGHADMARAMRLWPELAAFTEPFLRQYVAVHQGFQQFTFDQGRITLTLLIGDVLEQLPQLDARIDVWFLDGFAPAKNPDMWTPELFTQLARLSHAGTALGTFTTTGWVRRSLIEAGFTMKKVPGIGKKWEVMSGEYTGPPNAPMSAPWYARPTAPEGPREALVIGAGLAGSASAASLAARGWQVTVLERHDAAAREASGNPQGVLYLKLSAHGTALSQMILSGFGYTRRQLELLQRGQDWDACGVLQLAFDSKEAERQGRLADAFEGSLLRAVQRNEAEAIAGVGLPAGGLFYTEGGWVHPPALCKAQLQHPNIRLLAHHDVLALRKADGLWQAWAGDRLLASAPMVVLAGAADVKRFEPCAQLPLKRIRGQITRLPVTDASRALATVVCAEGYVAPPRGEEHTLGASFDFHSDDLTPTVAEHQGNLAMLDEISTDLARRLGTAALAPEQLQGRAAFRCTSPDYLPIVGPVADPAAFAEAYAVLAKDARQVPEVPCPWLEGLYVNSGHGSRGLITAPLSGELIAAWVSGEPLPLPRAVAEACHPNRFGLRRLIRGK
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD66_MOUSE
Sequence: MNLGDGLKLETELLDGKTKLILSPYEHKSKVSVKMGNKFKIAKCPLRTKQTGHTLKSTQNTYIGNENLSQKKISTLDTSQAKPENSRLTFSPSTDKQYSEKDSVRVQKEISPTTSNIRKIINTTGTCPVAKQKPCKKNPTAETMNSGLVCLTQDQLRQILMLSVNQGNGSVCLTETGEEEASQDSLHLINIPSQPKDVNDTGFLQNTEAASPVTSEHEHVHRRAQEAFQQCEQKAATENEWKPADIFSTLGERERDKSLLEARRAQWKKELDEQVALKKKEKEASQKWHNPWKPSDIECEKSQVHDQSKEARLLESPCSAIKQEQQRKWIEELNKQVEDDQQRKAEERMIYSKGEEHDRWAVHFDSLKSHPGSQSRLSSQLTHQHLESLCVSPDTQELADVNGVFTPPPGVQAEPSEKEQRARPVLEMAVSHGPKTNFLRSMTALLDPAQIEERERRRQKQLEHQKAIMAQVEENRRKKRLEEEQRKKEEQELELRLAREREEMQRQYEEDILKQRQREEIMTLKTNELFHTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIQNLGAQVDYKAFTTISSSHSDPEETADTSTASPKKDTGVQTDDVNLGIFNDALPPCGSVTEKGIRNISSPEISAEFSGQTDIRKENQELSMNKGTNLDKENSWHNGQCNQYRRTEKQTKLMKKCPKKPAWNINKPLKKYVPASAKYPAHLQKEKEEKKVQRQMELLHLVERNNPENLSQNRGISPLATSHRETESESRLHLIKKVEEPLKTPSVSKERFQTSPAVKNRTQQTQSNVLHLPLKNNDYEKETLTLGDGHTKLSDEMSEPSHFIPYVRTNEIYYLDPDAPLSRPSTQDNQYQKSHDCAREQELFDSDHIRDPLLNPKLVKNRDRQQAILKGLSELRQGLLQKQKELETNLIPLTANQEDNFSSSF
What is the function of this protein?
Microtubule-binding protein required for ciliogenesis.  May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity).  Plays a role in retina morphogenesis and/or homeostasis (PubMed:21680557).
What are the official names of this protein?
Coiled-coil domain-containing protein 66.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (By similarity). Enriched in the inner segment of the photoreceptor (PubMed:19777273).
Protein: GRPE_PSYIN
Sequence: MTEDKKTIPEEQVEAEQVVVEEVEAELVENDESAQPQEEAEASNEDLNMIEVLNKKLALAEQQIVDQQADVARAQADVVNARRIAAQDVQKAHKFALVKFADGLLPVIDSLEMAISHADKEDETLKPMIEGVELTLKSMLDTVDKFGLKVIDPKDEAFDPEKHQAMSMRAVPDVAPNQVIAVMQKGYELNGRVIRPAMVMVSKAED
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_COXBU
Sequence: MNESYQPTLIEQLAQEYWEENETFEVKEDLSREKFYCLSMLPYPSGDLHMGHVRNYTIGDVIARYQIHKGRNVLQPMGWDAFGLPAENAAIQRELPPAEWTRKNIKKMRKQLKQLGFAYDWSREITTCDSTYYRWEQWLFLQLYKKGLAYKKNAIVNWDPVDQTVLANEQIVDGRGWRSGAVVERREISQWFLKITDYSEELLKDLDELKEWPEQVITMQRNWIGQSQGVIINFNLEKGPDKLQVYTTRPDTLMGVTYLAIAPEHPLAKERAKKSKKIAAFLKKCKQTRVAEADIATQEKEGIDSGLFAVHPLSKEKLPIWIANFVLMEYASGVVMAVPAHDERDHEFALKYDLPLKPVIEPADGHDWDYNQAAYTNPGKLINSGSFNDIDSKTAFNVIADYLKNNGAGSRQTHYRLRDWGISRQRYWGTPIPIIYCKTCGTVPVPENQLPVLLPEDIIPTGHGSPLKETASFYKTRCPVCNKPATRETDTMDTFVESSWYYARYSCPDQDKVMLDDRAKYWTPVDQYIGGIEHAVMHLLYARFMHKILRDLGLLNSNEPFIRLLTQGMVLKDGAKMSKSKGNVVTPQSLIKKYGADTVRLFIIFAAPPEQDLEWSDSGVEGAYRFLKKLWGFSYRIKDALLAINQQKERSNYQWEAPEHRQTRQQIHECLQQANIDMERLQFNTVVSAVMKILNILIKLTTDNDAEAHLIREGTGILLRLLSPITPHISHHLWQSLGFGGDILDTPWPRPDPKALQTTELELIVQINGKLRGRIQVPTEASKEIIESTALNQENVQRHLADKKIKKVIVVPKKLINIVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_XANAC
Sequence: MSRAPLPLAAHERLIFALDVPSHDQAIAWVDRLGDSVSFYKIGMELLASGEYFHVLDALAKRDKRVFVDLKFFDIPATVAGTIRRLAQWPVSYCTVHGWHAGMLQAAAEANHGDMRLLAVTVLTSMGRPDLVAMGIDREPVDVVVERALAARAAGIDGVIASGQEAGPIRRATGPDFSIVCPGIRPGGPVGDDQQRTVGVAQAFIDGADAIVVGRPIRLASDPAAAADAIQAEIRAALMQNGD
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: REX_LACGA
Sequence: MDEIKIPKATARRLPLYYRYLIFLNDEGKEKVSSTELAEAVQVDSASIRRDFSYFGALGKRGYGYDVKNLLNFFKKILNQDTLTNVALVGVGNMGHALLNYNFKRTNNIRISAAFDINPEITGTIMSGVPVYDMSEMKKQLREQQITIAILCVPQTAAQKTANEMFDAGIKGIMNFTPLRLSAPSSVRVQNVDLATELQTLIYFLDSDKDKNKK
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_BUCAP
Sequence: MRHRKIGRKLNCKSDHRNAIFKNMACSLILNEIIKTTLAKAKELRRIVEPMITLSKIDTVAHRRLLFSRIRNNEVIAKLFKKIGPIFYNRSGGYTRILKCGFRFGDKAPMAYIELVDRVRKSKEKKKLSSNNNLIKNK
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RS4_THEPX
Sequence: MGRYTGPTCRLCRREGMKLYLKGDKCYTDKCPFARRGYAPGQHGQEKKKLTNYGMQLREKQKLKRYYGVLERQFERLYEEAERMKGITGENLLQLLERRLDNVVFRLGFAASRPQARQLVSHGHIEVNGKKVDIPSFLVKPGDVISVREKSRSMELIKNNLEVSRNVPDWLELNKDAFEGRVVSLPRREHIDLPIQEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: VHUD_METMP
Sequence: MAEPVIMAFVCYQUGYGAADLAGTSRMQYPASVRAIRVPCTGKFDITYALRAFQKGADAVFVAGUKPNECAFETGNFKAEERVKFGKQILDELGIGGERLEMFFMSGADAGKFTEAVKEMTDRVKKLGPNPIKA
What are the official names of this protein?
F420-non-reducing hydrogenase vhu iron-sulfur subunit D.
What is the protein family that this protein belongs to?
Belongs to the MvhD/VhuD family.
Protein: SYLC_HUMAN
Sequence: MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
What is the function of this protein?
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.  Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.
What are the official names of this protein?
Leucine--tRNA ligase, cytoplasmic, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein: B2L14_RAT
Sequence: MCSTSVYDLEDIPLEDDDPNSIEFKILAFYARHHVFKSTPAVFSPKLSRTRSLSQKALGTWSTDSWTQISLPCRDSLSSEKHISLGKKKSSWRTLFRVTEKEEEPPSSPKEIHAQGPFPVERQGRNQHWSRSLSSVEQCLESEAVDSKVACIANRVAEIVYSWPPPDDSQSQGGGKFKESVPKILHFELQGPQLRPCDSKKDGEDQIINRIVELLKYSGDQLGREIKRDKALVSIFQEGLSYSVFRTITDLFLRDVDTRGESEIKAQGFKAALAIDAIAKLTAIDNHPMNRMLGFGTKYLREYFSPWVQQNGGWEKILGLSHEEVD
What is the function of this protein?
Plays a role in apoptosis.
What are the official names of this protein?
Apoptosis facilitator Bcl-2-like protein 14, Bcl2-L-14.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_STAA9
Sequence: MMIIVMLLLSYLIGAFPSGFVIGKLFFKKDIRQFGSGNTGATNSFRVLGRPAGFLVTFLDIFKGFITVFFPLWLPVHADGPISTFFTNGLIVGLFAILGHVYPVYLKFQGGKAVATSAGVVLGVNPILLLILAIIFFIVLKIFKYVSLASIVAAICCVIGSLIIQDYILLVVSFLVSIILIIRHRSNIARIFRGEEPKIKWM
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SI1L1_HUMAN
Sequence: MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAPVGPPRSEGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKFHALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS
What is the function of this protein?
Stimulates the GTPase activity of RAP2A.  Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin.  Contributes to the regulation of dendritic spine morphogenesis (By similarity).
What are the official names of this protein?
Signal-induced proliferation-associated 1-like protein 1, SIPA1-like protein 1, High-risk human papilloma viruses E6 oncoproteins targeted protein 1, E6-targeted protein 1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Postsynaptic density. Synapse, synaptosome. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity).
Protein: KCY_STRP4
Sequence: MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAATYMALKNQLVVEEVEALLALLDQHPISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAIAAIPEVREKLVSLQQEIAQQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKENIAKGIETDLETLKKEIAARDYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAEAEKRM
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBID_BURO0
Sequence: MRDETPEQPAPLRFGYTTGSCATATSLAAARLLLAGQADDAVEIVLPKGQRVMMRLEFCRATADGAEAGTIKDAGDDPDVTHGALIFARVALAAAPGVRFHAGPGVGTVTRAGLMLPVGEPAINPVPRQMMTTHLEALAAEHGYAGGFDVTIGVEGGEMLALKTMNPRLGIVGGLSILGTTGIVRPFSCSAYIASIHQGIDVARANGIAHIAACTGNASEDAMRAHYQLPDMALIEMGDFAGAVLKHLRRAPVARLSMCGGFGKLSKLAAGHLDLHSRHSSIDLPLLAQWAAEAGANDALQAAMRAANTSQEALKLAQADGVPLGDLVCAHALRVARDIVPPSVVIEMFAIDRQGRFVGVAR
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: S4A5_RAT
Sequence: MKVEEKAGVKKLEPTSYRRRHPEQDFPSIHIGFPVPGYSQRKSDSKGHLSGLQRVQWSLQPDKSQQDLAGPDGIKASSLGGSVDFTKRIRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEGGLLRPELRERVSYVLLRKHRHQTKKPIHRSLADIGKSVSTTNRSSARSPSAGPTLHHSTEDLRIRQSTSYGHLCHAQSRSMNDISHTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLAQSSMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGVDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGRSGASAGGGGSGGGAGGSGAGGGGSGNEAEMPAMHEIGEELIWTGRFFGGLRLDVKRKLPWFPSDFYDGFHIQSISAVLFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKANGLDYMEFRLWIGLHSAIQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINTDFKPDSITTYKCECVAPDTVNTTTVNDSALLVPNTNMSVYTPLNLTALDWSLLSKKECLSYGGRLLGSSCQFVPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRTLVADFSIVFSILLFCGIDACFGLQTPKLHVPNVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLRKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGVMVFILTGISVFLAPILKYIPMPVLYGVFLYMGVASLNGIQFWDRCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLWILKSTMAAIIFPVMILGLIIVRRLLDLIFSQHDLAWIDNILPEKEKKESDRKKRRKEVHENTDKEPQFLPPSVVKIPMEGIPSDPQNGIHCVGRKRSSSWSHSL
What is the function of this protein?
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3.
What are the official names of this protein?
Electrogenic sodium bicarbonate cotransporter 4, Solute carrier family 4 member 5.
What is the protein family that this protein belongs to?
Belongs to the anion exchanger (TC 2.A.31) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localized predominantly to the basolateral sinusoidal membrane in hepatocytes.
Protein: COF2_HUMAN
Sequence: MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
What is the function of this protein?
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner.  Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190).  It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin.  It is the major component of intranuclear and cytoplasmic actin rods.  Required for muscle maintenance.  May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).
What are the official names of this protein?
Cofilin-2, Cofilin, muscle isoform.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
What are the subcellular locations of this protein?
Nucleus matrix. Cytoplasm, cytoskeleton. Note=Colocalizes with CSPR3 in the Z line of sarcomeres.