PharMolix/UniProtQA huggingface dataset:
Protein: DPH2_DICDI
Sequence: MSAAPPPSIYTESFSTSSNNTTESESINVEETRENILSGFSFEEYFQVSESISVIIKNNFKKIALQLPDYLLWASSELSNKIQNSVPLEYGIKVFILGDTSYGSCCVDEVTSSHLKSDFIIHYGHSCLSPSSKIPVQYVFGKKKNFNVDKFSIELNKLVESKKEENFVIFYDLLYHHNRDSIENLYKNNDNIIVTNINNFNNIYLNNSFKNNKLNETQNCNNNYNNDCCGSDNNNNNNDSGCCGGNNNNNNNNSGCCQSQSQQQQQQNDCCQQKLNNEINNENDNNNEELISGRKIEFKNEKDIKKFNFIWIGEESLTLTNLLMNFNQQMVYRYYIDDNKLLQETLPRNKSLMRRYHISEKCKDASIIGIVVSTLSVQKYSETIDGLKKLIIASGKKPYVFVVGRLNVPKLANFSEIDIYVIVACHENTMVDSKDFYKPIATPFELNLSLRNEKWTGEYITDFGRVFPKLIKDLSFDEDDENKCEIPEDQVEDDQGNIHHFSLVTGRIVIQNKNQSTLQQQQQQQQTQQSGDLISVNNQFKQVSLVGEHLSNKTYKGLDMRIGETPVTTAIEGMSGIPKNYNTDKNNL
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).  Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase (By similarity).  Facilitates the reduction of the catalytic iron-sulfur cluster found in the dph1 subunit (By similarity).
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, Diphthamide biosynthesis protein 2, Diphtheria toxin resistance protein 2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH2 subfamily.
Protein: ATP6_STRP6
Sequence: MEEAKIPMLKLGPITFNLTLLAVCIVTIAVIFAFVFWASRQMKLKPEGKQTALEYLISFVDGIGEEHLDHNLQKSYSLLLFTIFLFVAVANNLGLFTKLETVNGYNLWTSPTANLAFDLALSLFITLMVHIEGVRRRGLVAHLKRLATPWPMTPMNLLEEFTNFLSLAIRLFGNIFAGEVVTGLIVQLANYRVYWWPIAFLVNMAWTAFSVFISCIQAFVFTKLTATYLGKKVNESEE
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SH2B2_RAT
Sequence: MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSESNNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATSVPPRPAEGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY
What is the function of this protein?
Adapter protein for several members of the tyrosine kinase receptor family.  Involved in multiple signaling pathways.  Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR.  Suppresses PDGF-induced mitogenesis (By similarity).  Involved in stimulation of glucose uptake by insulin.  Involved in coupling from immunoreceptor to Ras signaling.  Acts as a negative regulator of cytokine signaling in collaboration with CBL.  Induces cytoskeletal reorganization and neurite outgrowth in cultured neurons.
What are the official names of this protein?
SH2B adapter protein 2, Adapter protein with pleckstrin homology and Src homology 2 domains, SH2 and PH domain-containing adapter protein APS.
What is the protein family that this protein belongs to?
Belongs to the SH2B adapter family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=Recruited to the membrane by binding to an autophosphorylated receptor after receptor stimulation by its extracellular ligand.
Protein: KAD_THEKO
Sequence: MNILIFGPPGSGKSTHSRTIMEKYGLVYISSGDLIRREIERKSSLGREMEAYLSRGDLIPDTIVNTLIISKLRRQRENFILDGYPRTPEQVISLENYLFDHGIKLDLALEIFIDEDTSVERISGRRICPNCGAVYHVKYNPPKVPGICDVCGSELIQRADDREEVVRKRYRIYSKNMEPIIKFYRAKGIYVRVDGDGPISEVWKRIQPLLDYIHSREEKRKEHE
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S1PR1_BOVIN
Sequence: MGSTRIPLVKALHSPVSDYVNYDIIVRHYNYTGKLKISADKDNGIKLISVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNRFRSFLLISACWVISLILGGLPIMGWNCISTLPSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLGVFIACWAPLFILLLLDVGCKVKTCDILFRTEYFLVLAVLNSGTNPIIYTLSNKEMRRAFVRIMSCCKCPSRDSASKFTRPIIAGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS
What is the function of this protein?
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins.  Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases.  Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1.  Required for normal chemotaxis toward sphingosine 1-phosphate.  Required for normal embryonic heart development and normal cardiac morphogenesis.  Plays an important role in the regulation of sprouting angiogenesis and vascular maturation.  Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development.  Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs.  Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis.  Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity).
What are the official names of this protein?
Sphingosine 1-phosphate receptor 1, S1P receptor 1, S1P1, Endothelial differentiation G-protein coupled receptor 1, Sphingosine 1-phosphate receptor Edg-1, S1P receptor Edg-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn- glycero-3-phosphocholine. Ligand binding leads to receptor internalization (By similarity).
Protein: RAX3_ARATH
Sequence: MGRAPCCDKANVKKGPWSPEEDAKLKSYIENSGTGGNWIALPQKIGLKRCGKSCRLRWLNYLRPNIKHGGFSEEEENIICSLYLTIGSRWSIIAAQLPGRTDNDIKNYWNTRLKKKLINKQRKELQEACMEQQEMMVMMKRQHQQQQIQTSFMMRQDQTMFTWPLHHHNVQVPALFMNQTNSFCDQEDVKPVLIKNMVKIEDQELEKTNPHHHQDSMTNAFDHLSFSQLLLDPNHNHLGSGEGFSMNSILSANTNSPLLNTSNDNQWFGNFQAETVNLFSGASTSTSADQSTISWEDISSLVYSDSKQFF
What is the function of this protein?
Transcription activator (By similarity).  Positively regulates axillary meristems (AMs) formation and development, especially during inflorescence.
What are the official names of this protein?
Transcription factor RAX3, Myb-related protein 84, AtMYB84, Protein REGULATOR OF AXILLARY MERISTEMS 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL16_ONYPE
Sequence: MLMPKRTKYRRPHRVSFEGKSKGKNVIANGNHALVAKEGAFITNKQIEAARIAMTRYMKRTGKVWINIFPHLSLTKKPLEVRMGSGKGSPEEWVAVVKTGKVLFEVKDTTNSSKVEMEALRLASHKLPIKTKIVKKGAEV
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: 3CAR2_PINBN
Sequence: MSLISAVPLASSCVSKSLISSVREHTALRRAIATLQMSRRGKSVAASIRMSSATAGSDDGVKRRIGDYHSNLWDDNFIQSLSSPYGASSYGEHADRLIGEVKEIFNSFSIADGELISPVNDLLQQLWMVDNVERLGIDRHFQTEIKVALDYVYRYWSEEGIGCGRDSAFTDLNTTALAFRIFRLHGYTVSSDVFEHFKDQKGQFAASANDTELQTRSVFNLFRASLIAFPEEKVLEEAEKFAAAYLKAALQTLPVSGLSREIQYVFDYRWHSNLPRLEARSYIDILADNTISGTPDANTKKLLELAKLEFNIFHSVQQKELQCLWRWWKEWGCPELTFIRHRYVEFYTLVSGIDMVPEHATFRLSCVKTCHLITILDDMYDTFGTIDELRLFTAAVKRWDPSATECLPEYMKGVYMVLYETVNEMAKEAQKSQRRDTLGYVRQALEDYIGSYLKEAEWIATGYVPTFQEYFENGKLSSGHRIATLQPILTLSIPFPHHILQEIDFPSKFNDYAASILRLRGDTRCYKADSARGEEASCISCYMRDNPGSTQEDALNLINGMIEDMIKKLNWEFLRPDNNAPISSKKHAFNISRGLHHFYNYRDGYSVASKETKDLVIKTVLEPVLM
What is the function of this protein?
Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens (PubMed:23679205).  Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (+)-3-carene (PubMed:23679205).
What are the official names of this protein?
(+)-3-carene synthase 2, chloroplastic, Terpene synthase (+)3car2, PbTPS-(+)3car2.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AHPD_MYCS2
Sequence: MSIDNIKSALPEYAKDLKLNLGSIANTTELTEQQLWGALVATAAATKNARLLREISEDALDILSEEAYNAALGAAAIMGMNNVFYRTKGQLDGKYDDLRAGLRMNIIGNPGVAKEDFELWSLAVSAINGCGHCLAAHEKTLRDADVARTTIFEAIRLASIVSGVAQALLTADTLAAV
What is the function of this protein?
Antioxidant protein with alkyl hydroperoxidase activity.  Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
What are the official names of this protein?
Alkyl hydroperoxide reductase AhpD, Alkylhydroperoxidase AhpD.
What is the protein family that this protein belongs to?
Belongs to the AhpD family.
Protein: GTF1_LEUME
Sequence: DTVPRVYYADLYTDDGQYMATKSPFFDAINTLLKARVQYVAGGQSMSVDSNDVLTSVRYGKNAMTASDTGTSETRTEGVGVIVSNNAELQLEDGHTVTLHMGAAHKNQAYRALLSTTADGLAYYDTDENAPVAYTDANGDLIFTNESIYGVQNPQVSGYLAVWVPVGAQQDQDARTASDTTTNTSDKVFHSNAALDSQVIYEGFSNFQAFATDSSEYTNVVIAQNADQFKQWGVTSFQLAPQYRSSTDTSFLDSIIQNGYAFTDRYDLGYGTPTQYGAVDHVRA
What is the function of this protein?
Involved in the production of dextran, an extracellular glucan polymer.
What are the official names of this protein?
Dextransucrase 1, Glucansucrase 1, Sucrose 6-glucosyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 70 family.
Protein: GCS2_SORC5
Sequence: MTDVEGLLDGQFTLGIEEEFQIVDAETRELRSYVSQLLEGGPGHELLRGRARPEMHQSVVETGTGVCRDIRQARGELVELRGSLNALARRGGMRIVAAGTHPFSDWKKQDITDGERYRCIVEDLQDVARANLIFGLHVHVGVKDREVAMALANQVRYFLPHILALSTSSPFWLGRPSGLKSTRSEIFKRFPRTGIPGLFESHGHFQRFVDLLVKTGCIDNAKKIWWDVRPHPFFDTVEVRICDMTTRLDDTVALAALVQAVMGKLYLLYRRNLGFREYRQELIEENKWRAVRYGLDGQLIDFGKQEQVPVRHLVGELLEFVQESAEIFGSQRELERVRRILHEGTSADRQLAVYARTKSFHAVVDDLIEQSSLGL
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: DAPF_METEP
Sequence: MSLLANRRFLKMHGAGNAIVVLDLRGTAVRVTPAEARAIAADVHSRFDQLMVVHDPVTPGTDAFMRIYNTDGSESGACGNGTRCVGYALLDDPAMARPAENGALTLETKAGLVAVKRITERSFTVDMGQPRLRWDEIPLAEPFLDTRRIELQVGPIDDPILHSPAAVSMGNPHAIFFVERDPDSYDLGRIGPLLEAHPIFPERANISIAEVTGRDTIKLRVWERGAGLTLACGTAACATVVAASRLRMIGRAARVALPGGELSIEWRADDHVLMTGPVYLEGEGTFSPDLFAGIDG
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDHS_BRUSI
Sequence: MSGSYPFIDIAALDSVREGFARGDAQLVLAHDLSTVLWVNGPGAKLFGYNRVEDLIEGQLDLPVATRRQIAAFSSENTSAPSAVAVRLGGGLRSELTHLHVSNIKLPDGVAALLVATQMPDNSAEAAISGLGDDSTHIALVDTVGKVVAASPRFALLDISASTLEDLIVEAGDATDRIVKRRIRTGSHSVPGAIARLTDTPALHLLCIVGDAPAQFQTAAEAVPLPDNAEAVLEEILPEQGDAPAQQAQKTHAEQPRPKTFAFDHDAPPARFIWKVGPDGTFSEISPDLAAVVGPNSADIVGRRFSDVANVFGFYTDGSIAALLLERDTWSGKRLLWPVEGTRLRVPVELAALPVYSRDREFLGFRGFGIVRPAEAEADPEEIGLALAGGIPQNRKPRKEPAETARMVGEDDVLALSEEVANDDQPAAVLPKPPLDITPTPGRRDSDKVISLLNSCAQEKVAADQAKFLKEKERATRPEGGLTKTERNAFREIAERLRKQGLANTRAESETPVSETSSIEPVEPTPPVKTRSEPIQPDETALLANLPVPVIIHSGDAIHYVNQALLDITGYESLDDIRSAGGVDVLFNSESDDGETRQSMVLRHADGSEEPVDTHLNAIAWRGGRALMLSLMPVTAADLPAPAELPAANDEEKQALEAHVEELKTILDTATDGVVLIDPEGRIRSMNHSASALFGYERDEAEGKFFSMLFAIESQRAAMDYLHGLSGNGVLSVLNDGREVIGREAKGGFIPLFMTIGKLPHTRGFCAVLRDITQWKRTEEELTNARKEAERASNQKTEFLARISHEIRTPLNAIIGFSELMADEKFGPIGNDRYRDYLRDINRSGNHVLALVNDLLDISKIEAGALDMQFEAVSLNDAIGEAIALMQPQANRERVIIRSSFQSNLPDIVADSRSIKQVALNLLSNAVRFTAPGGQVIVSTSYELNGDVVMRVRDTGIGMSKSEVEQALKPFRQINALEGRKAESAKDWRNEGTGLGLPLTKAMVEANRAQFAIDSNPGQGTVVEIVFPPTRVLAD
What is the function of this protein?
Functions as a polar differentiation marker.  Essential protein that, by localizing in the old pole of dividing cells, controls cell division and maturation, probably through control of DivK phosphorylation status and cellular distribution, which in turn regulates CtrA, a transcriptional regulator of the minB operon.  The asymmetrical localization of this protein is probably required for cells to enter a new division cycle (By similarity).
What are the official names of this protein?
Cell-division control histidine kinase PdhS.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at the old pole of dividing cells. Colocalizes with DivK (By similarity).
Protein: SYR_VIBA3
Sequence: MNIQALINDKVSQALEAAGAPAGSPAAVRQSAKPQFGDYQANGIMGVAKRLGTNPREFAQKVLDVLNLDGIASKVEIAGPGFLNIFLDETFLAQQADAALADSRLGVSAAEAQTIVADYSAPNVAKEMHVGHLRSTIIGDAVVRTLEFLGHKVIRANHIGDWGTQFGMLIANLERIQAETGEVSMELSDLEQFYRESKKLYDEDEEFAVKARGYVVKLQGGDAYCAEMWKKLVDVTMVQNQRNYDRLNVSLTRDDVMGESMYNHMLSNIVSDLQTQGLAKESDGAQVVFLDEYKNKDGDPMGVIVQKRDGGFLYTTTDIACAKYRFEELGADRVLYFIDSRQHQHLMQAWTIVRKAGYVPESVSLEHHAFGMMLGKDGKPFKTRAGGTVRLADLLDEAEVRATQLIESKNPELAEDEKKTIANTVAMAAVKYADLSKHRTTDYVFDWENMLAFEGNTAPYMQYAYTRVASIFAKAGISMDSLEGEIKITEEKEKALIAKLLQFEEAVQSVAREGQPHIMCSYLFELAGQFSSFYEACPILVAEDETVKQSRLKLAALTAKTIKQGLSLLGIETLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_STRPF
Sequence: MIKITFPDGAVREFESGVTTFDIAESISKSLAKKALAGKFNDQLIDTTRAIEEDGSIEIVTPDHKDAYEVLRHSAAHLFAQAAKRLFPNLHLGVGPAIAEGFYYDTDNAEGQISNEDLPRIEAEMQKIVTENYPCIREEVTKEEALELFKDDPYKVELINEHAGAGLTVYRQGEFVDLCRGPHVPSTGRIQVFHLLNVAGAYWRGNSDNNMMQRIYGTAWFDKKDLKAYLTRLEEAKERDHRKLGKELDLFMISQEVGQGLPFWLPDGATIRRTLERYITDKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPVMDMGDGEEFVLRPMNCPHHIQVYKNHVRSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHIFVTPEQIQEEFRRALQLIIDVYADFNLTDYRFRLSYRDPNDTHKYYDNDEMWENAQSMLKAALDEMGVDYFEAEGEAAFYGPKLDIQVKTALGNEETLSTIQLDFLLPERFDLKYIGADGEEHRPVMIHRGVISTMERFTAILIETYKGAFPTWLAPHQVTVIPISNEAHIDYAWEVAKTLRDRGVRADVDDRNEKMQYKIRASQTSKIPYQLIVGDKEMEDKSVNVRRYGSKATHTESVEEFVENILADIARKSRPDAQA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_MYCGI
Sequence: MAVEMFYDADADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVEVKVGLKEGSKSRDKVTEQGLDVDTPAEVAKWADVIMLLAPDTAQAEIFTKDIEPNLEDGNALFFGHGLNIHFGLIKPPANVTIGMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPKGEGQALALSYAAAIGGARAGVIKTTFKDETETDLFGEQAVLCGGTEELVKTGFDVMVEAGYEPELAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDADTKKRMQDILKDIQDGTFVKRLVANVEGGNKELEGLRKQNAEHPIEVTGKKLRDLMSWVDRPITETA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: MEND_SALHS
Sequence: MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKVSQQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFASHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHAGALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRLASDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAHHRGRRLVAKIADWLELHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPTPQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPAATVIELVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: SNU13_CRYNB
Sequence: MSAQPNPKAFPLANAQLTNQILDLIQQAQHYKQLKKGANEATKTLNRGICEFIVMTADVEPIEIVLHLPLLCEDKNVPYVFLPSKTALGRACGVSRPVIAASVTTNEARELNAQIQAVKNEIEKLLI
What is the function of this protein?
Common component of the spliceosome and rRNA processing machinery.  In association with the spliceosomal U4/U6. U5 tri-snRNP particle, required for splicing of pre-mRNA.  In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs.  Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity).
What are the official names of this protein?
13 kDa ribonucleoprotein-associated protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: EFTU_TROWT
Sequence: MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAISRVLSERLPSNTNVKQDFDAIDSAPEERQRGITINISHIEYETEKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGAMAQTREHVLLAKQVGVPYLLVALNKADMVSDEEILELVELEVRELLSNHGFDGENVPVVRVSGLKALEGDQKWGDAVMELMKAVDESIPDPVRDRDKPFLMPIEDVFTITGRGTVVTGRAERGVLAVNSEVEIVGIRPTQKTTVTGIEMFRKQLDEAWAGENCGLLLRGTKREDVERGQVVVKPGSVTPHTKFEGKAYILSKDEGGRHNPFYSNYRPQFYFRTTDVTGVITLPEGTEMVMPGDTISITVDLIQPIAMEEGLGFAIREGGRTVGAGTVVKILE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTC4_YEAS7
Sequence: MVGPGLGINQVRRKGVYSTKKGSGDNLLLMKRQGKHDIHDRESDDLSGHDAFSPSKKRGKIDSITEDEIEVKKLSTVATFDKLSRSFPNSEVQAAKNAALRGKEKEEEKVVSIPLIQNLKNEDIESIKCRNNNLLDGKKLLLEAELSAVEDNQIFSSSFPEDKKLSLQSCLSSKEQIIKKLQVREEYMSKFKLPPMLFSDELLTEVEPFMPIVMDILEGKISSAYYFEAKNAFKNSQKAYLSVDEFRKLNLNKFTAGFYGLKRQLRVGEEIAKRYKRALTHNQPATLKWWGITDFCNYVLAPETLTSFCIYQLNLSNKSCSSKTPNKHPKQQLNEKEYYYDPELRMLAYDLLEDTVEYGIIVADSDPIEQWEAAIEEDRLRELKLDVHNYSSRRWRLDTHD
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 4.
What is the protein family that this protein belongs to?
Belongs to the RTC4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL15_ERWT9
Sequence: MRLNTLSPADGSKHAPKRLGRGIGSGLGKTGGRGHKGQNSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAMVTAEVRLSDLAKVEGGIVDLNTLKAANIIGIQMEFAKVILSGEVSAPVTIRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: IHFB_PSESM
Sequence: MTKSELIERIVTHQGLLSSKDVELAIKTMLEQMSQCLATGDRIEIRGFGSFSLHYRAPRVGRNPKTGQSVSLDGKFVPHFKPGKELRDRVNEDEEEGF
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: HACB_METJA
Sequence: MIIKGRAHKFGDDVDTDAIIPGPYLRTTDPYELASHCMAGIDENFPKKVKEGDVIVAGENFGCGSSREQAVIAIKYCGIKAVIAKSFARIFYRNAINVGLIPIIANTDEIKDGDIVEIDLDKEEIVITNKNKTIKCETPKGLEREILAAGGLVNYLKKRKLIQSKKGVKT
What is the function of this protein?
Component of a hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids.  Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate).  Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate, and even the non-physiological cis-homo(4)-aconitate with similar efficiency.  These reactions are part of the biosynthesis pathway of coenzyme B.  Can also catalyze the hydration of maleate to (R)-malate, and that of cis-aconitate.  Cannot catalyze the hydration of citraconate and the dehydration of (S)-homocitrate, citramalate, 2-isopropylmalate, 3-isopropylmalate, citrate or threo-DL-isocitrate.
What are the official names of this protein?
Methanogen homoaconitase small subunit, HACN, Homoaconitate hydratase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.