PharMolix/UniProtQA huggingface dataset:
Protein: RL19_STRP3
Sequence: MNPLIQSLTEGQLRSDIPNFRPGDTVRVHAKVVEGTRERIQIFEGVVISRKGQGISEMYTVRKISGGIGVERTFPIHTPRVDKIEVIRHGKVRRAKLYYLRALQGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RR4_CUSRE
Sequence: MSRYRGPRFKKIRRLGALPGLTNKRPRTVRDLRNQSRSGKKSHYRIRLEEKQKLRFHYGLTERQLISYVRIARKAKGSTGEVLIQLLEMRLDNILFRLGMAYTIPAARQLVNHRHILVNGHIVDIPSYRCKPRDIITSKDKPKSGALIKNSIKAFPREELPNHLTLHPAPYKGLINQIIDTKWVGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
Plastid 30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid.
Protein: CH602_MYCTU
Sequence: MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF
What is the function of this protein?
Cleaved, monomeric GroEL2 is biologically relevant and significantly contributes to Hip1-mediated dampening of macrophage responses during M. tuberculosis (Mtb) infection (PubMed:24830429).  Within macrophage, the cleaved form is able to detach from the bacterial surface and crosses the phagosomal membrane towards mitochondria organelles where it interacts with the host stress-70 protein (HSPA9 or mortalin) and blocks macrophage apoptosis, which promotes Mtb survival in the hostile macrophage environment (PubMed:28288970).  The cleaved form is poorly immunostimulatory and is unable to promote DC maturation and antigen presentation.  Proteolytic cleavage of GroEL2 allows Mtb to prevent optimal DC-T-cell cross talk during infection (PubMed:29133346).
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, 65 kDa antigen, Antigen A, Cell wall protein A, Chaperonin-60 2, Cpn60 2, Heat shock protein 65, HSP65.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Secreted, capsule. Cell surface. Secreted, cell wall. Note=Although thought of as a cytoplasmic chaperone this protein is routinely found extracellularly in the absence of cell lysis. SUBCELLULAR LOCATION: [Cleaved form]: Secreted. Host mitochondrion. Note=Exits phagosomal membrane and reaches macrophage mitochondria.
Protein: RS8_BUCCC
Sequence: MSMQDPIADMITCIRNGQFSNKIFVIVPFSRLKENIVKVLKFEGYIINYKIKKNNNKVLKIFLKYFNGKSVIENIKRISRPSLRRYCNKRNLPIVMNNLGIAIISTSRGVMTDRIAREKGLGGEIICYVD
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PSBL_PROM9
Sequence: MQVNENPNKVPVELNRTSLYLGLLSVFVLGILFSSYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: EFTS_RUBXD
Sequence: MATQIEKIKQLREETAAGMMDVKRALEESGGDLDGARRILKERGQAIAAKKSRRETHEGRIEAYVHFNGRVGVLVEVNCETDFVARTPEFREFCRDIALHIASMKPLCVAPEDVPEEALAEEREIAEKQAAEMGKPEHITRQIVEGRLKKWVSEQALLTQPFAKDPGKTVGELLQETVSKVGENVVIRRFVRYEL
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFB5_CANGA
Sequence: MVRARRGVLLKCDPSIKALIVQIDSERHDIILEELDETHLLVHPTKVEFIKMELNRLLSKNIYNPLDEEEEEH
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH subunit TFB5, TFIIH subunit TFB5, RNA polymerase II transcription factor B subunit 5.
What is the protein family that this protein belongs to?
Belongs to the TFB5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL22_ALIB4
Sequence: MAKAILKFIRVSPIKARLIAREVQGMNAEYAIASLQFTPNKAAGIISKVIASAVANAGLDPVDAVITSARVDKGPVLKRFTPRARGSASPKHKPTAHIMIEVAAATKGDK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CH10_XANAC
Sequence: MSIKPLHDRVVVKPIEADEVSAGGIVIPDSAKEKSTKGEVVAIGAGKPLDNGSLRAPVVKVGDKVIYGQYAGSSYKSEGVEYKVLREDDILAVIG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNCB_SHIFL
Sequence: MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDLLGIYADAIREQIQAMQHLRLQDDEYQWLSALPFFKADYLNWLREFRFNPEQVTVSNDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDFSALTAGLDMSRFHLMDFGTRRRFSREVQETIVKRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQRAALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLGIDPQSKTLVFSDNLDLRKAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPHIKKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: NQOR_ECO5E
Sequence: MAKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMSPQLFEKAGGKTQTAPVATPQELANYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: RK2_ANEMR
Sequence: MGIRSYQAYPPGTRDGSIVNSKEMVNSKEMIESEPQKVLVRGRHIARGRNHRGIITSRHRGGGHRRLYRMIDFRRDKRDVSGEIKTIEYDPNRNTCICLTNYGDGKKRYILYPHGIEIGNKIISGIEAPISIGNTSPLSTNMPLGASVHNIETRPGRGGQLVRAAGTTAKILAKEGQLVTLKLPSGEIRSLPQKCFATIGQIGNIDANNLKLGKAGSRRWLGKRPSVRGVVMNPIDHPHGGGEGKVPIGRKKPLTPWGHPALGRKSRKRRKYSDTLILRRRMA
What are the official names of this protein?
50S ribosomal protein L2, plastid.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid.
Protein: RS20_CHLT2
Sequence: MAPRKPSKKVGPQKRPSAEKRVITSKKKQLRNQSFKSKVRTILKKFELAVQSGDVESISAGLRSVYSIADKAVKRGIFKKGKADRVKSRASERACPAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: SRD18_CAEEL
Sequence: MIIFFEIWHWSWALLGCYLNLLLAYLAIFKSPKAIKSYATLIINYAATDFVECALDSFLQTRLLAVPGEAELVYIFNGPCKYIGSISCKVGLSFFLHCLTHSVWSLLLSFGYRFYILHNPSLSRLVLLKLILVFYIPSLIQALTYWTIFASREEILPLARQWFPYYDLDAETGVLTGIIDLTNFVAIYSIGHICLPFFPVYITIFILRQKIINQLHVKQHVMSPDTKAAHSQLLKALTIQAFIPIFVGIAVTFYFLSQSGLVRSPILEYSIYAVAILAPALSPITYLYFVRPYRQNVKRFIANPFKILLNTNTGSSIGVFHSGGRPSNFATTLNTSR
What are the official names of this protein?
Serpentine receptor class delta-18, Protein srd-18.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein srd family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ARGE_ERWT9
Sequence: MKTKLPNFIEIYRQLIATPSISATDSALDQSNETLINLLGGWFRDLGFTVEVQPVPGTRNKFNMLAKSGSGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDNKLYGLGTADMKGFFAFILDTLRDVELSTLKKPLYILATADEETTMAGAKYFSESTALRPDCAIIGEPTSLKPVRAHKGHISNAIRIQGQSGHSSDPGRGVNAIELMHESITQLMALRNTLKERYRHAGFAIPYPTMNFGHIHGGDAANRICACCELHMDIRPLPGLTLSDLDGLLNEALAPVSARWPGRLTVGELHPPIPGYECPREHQLVQVVEKLLGRETEVVNYCTEAPFIQQVCPTLVLGPGSIEQAHQPDEFIDTAFIKPTRDLIAQVVHHFCHH
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSBA_SHEDO
Sequence: MTASPKNEMSTVFKRLMTYVMPMKGMLTLSILGLIVYGLVDAAFIAFIKPFIDEGFSQNPTVVAGVELPTSGGFSANKDVMLMAPLVVIGMFTLRGVANFVSTYCISYLSAQLIMDMRQQVFEHYLRLPVSYIDRENSGNLISRVTFDTEQIARASGSALISIVRDSITVIGMLALMFFYSWKLSLCILVIGPLMGVVISIVSKRFRKVSVQIQSAMGGVTATTEQMIKGHKNVLSFGGQETESKRFYEVNDRNRYQNMKLAMAQSVSQPVIMIIGSFALAFVLYAASLDSMKLELTAGTFAAILGAMLAMLQPIKNLTRVNAEFQRGIAACTTVFELLDTLPESDTGAHQVERVQGHLRFDNVSFSYPGQAKPALNNIDFDVKPGKTVALVGRSGSGKSTMASLITRFYTGLEQGDIRLDDVSIYDYSLKSLRSQVALVSQQVTLFNDSIANNIAYAYPGEVSREQILKAATLAHAMEFIEQLPEGLDTQVGENGVLLSGGQRQRIAIARAMLRDAPVLILDEATSALDTESEKAIQLGLDNLRHNRTSIVIAHRLSTIESADEILVIDQGKIIERGTHASLIEKKGAYAGLYQMQFGE
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y243_CHLAB
Sequence: MHQEYWILEVKVTPKSKQNTIVGFEGEVLKIRVTEVPEKGKANEAVIALLAKALSLPKRDITLIPGDTSRKKRILLPKSTESIVSHWREKGFYAGL
What are the official names of this protein?
UPF0235 protein CAB243.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: GLNA_SULAC
Sequence: MPGLPKNEHEALEFLKSNNIKWVDLQFTDLLGKLQHITIPSNEFDESSFKVGFGKLDGSSIKGFTSIYESDMVLLPIPQTMTLIPWMQGVARVLTKVFWGGGKGRFERDPRGIAEEAEKYQSEQGYVSYFGPELEFFVFDKVEVDASLPQSGTGYKIHSREAPWSKNGGYVIRYKEGYYPASPVDQLMDIRLEIISTLVDYFGFTIEAAHHEVATAGQGEIDFRFSTLADTADKVQVLKYVTKNIASKRGMIATFMPKPFFGDNGSGMHTHFSLWTKDGKNLMYDPNDEYAELSQIGRYIIGGLLEHGRALSAIVAPTTNSYRRLVPGYEAPVYLVWSKSNRSAAIRIPAYYKGMEKAKRLEYRPPDPSSNPYLVFSAILMAGLDGIRRKLDPGDPVDENIYHMSEEKKRSLKIRELPGSLDEALNELESDNEFLKPVFNSSILQAYLDLKKEEAKMMQLYPHPMEIYQYLDS
What is the function of this protein?
Probably involved in nitrogen metabolism via ammonium assimilation.  Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I alpha, GSI alpha.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA5_MOUSE
Sequence: MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit alpha type-5, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
Protein: CDAS_BACSP
Sequence: MFLEAVYHRPRKNWSYAYNGTTVHLRIRTKKDDMTAVYALAGDKYMWDHTMEYVPMTKLATDELFDYWECEVTPPYRRVKYGFLLQQGHEKRWMTEYDFLTEPPRNPDRLFEYPFINPVDVFQPPAWVKDAIFYQIFPERFANGDTRNDPEGTLPWGSADPTPSCFFGGDLQGVIDHLDHLSKLGVNAVYFTPLFKATTNHKYDTEDYFQIDPQFGDKDTLKKLVDLCHERGIRVLLDAVFNHSGRTFPPFVDVLKNGEKSKYKDWFHIRSLPLEVVDGIPTYDTFAFEPLMPKLNTEHPDVKEYLLKAAEYWIRETGIDGWRLDVANEVSHQFWREFRRVVKQANPDAYILGEVWHESSIWLEGDQFDAVMNYPFTNAVLDFFIHQIADAEKFSFMLGKQLAGYPRQASEVMFNLLDSHDTARLLTQADGDKRKMKLAVLFQFTYFGTPCIYYGDEVGLDGGHDPGCRKCMEWDETKHDKDLFAFYQTVIRLRQAHAALRTGTFKFLTAEKNSRQIAYLREDDQDTILVVMNNDKAGHTLRCLSGMHSGPICGTTMS
What is the function of this protein?
Hydrolyzes alpha-, beta- and gamma-cyclodextrins and the resulting linear maltodextrins, with the highest activity with beta-cyclodextrin (cyclomaltoheptaose).  Soluble starch is hydrolyzed slowly, but it is nevertheless preferred over pullulan as a substrate.  Is able to hydrolyze amylose and amylopectin, with a very strong preference for amylose, with maltose and glucose as the main products (PubMed:9606956, PubMed:10620329, PubMed:16536613).  Maltose and glucose are the main hydrolysis products of cyclomaltodextrins, maltodextrins and starch, whereas panose is the main hydrolysis product of pullulan.  Acarbose is partially hydrolyzed to glucose and pseudotrisaccharide.  No activity with maltose as substrate (PubMed:9606956, PubMed:10620329).  Has transglycosylating activity with high concentrations of maltotriose, maltotetraose and starch (PubMed:9606956).
What are the official names of this protein?
Cyclomaltodextrinase, CDase, CDase I-5, Cyclomaltodextrin hydrolase, decycling.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: Y1570_METJA
Sequence: MNWQDPLVKKFLYLIVAMVILCPLGILLVWNYGDAWGEWGPEDVAEKVGEDKVSGLLHLADIWSYAPLPDYDIPGWDDPFHASIGYIISAIVGVILCVGAYYALIKIVNPKAAAG
What are the official names of this protein?
Uncharacterized protein MJ1570.
What is the protein family that this protein belongs to?
To M.thermoautotrophicum MTH1706.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLD_SHESA
Sequence: MTAQIIDGKAIAQSIRTQLREKVTARKEAGQRVPGLAVILVGADPASQVYVGSKRKACEEVGFISRSYDLDTSYTEEALLALIDELNDDPTIDGILVQLPLPAHIEDSKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGVDTYGLDAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKNLEQKIRQADLVVVAVGKPGFIPGEWIKPGAIVIDVGINRLENGTLVGDVQYDVAAQNASFITPVPGGVGPMTIASLLENTLYAAEQYHD
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TYRO_HUMAN
Sequence: MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
What is the function of this protein?
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.  Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity).  In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:28661582).
What are the official names of this protein?
Tyrosinase, LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Melanosome membrane; Single-pass type I membrane protein. Melanosome. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Protein: GLMM_OCEIH
Sequence: MGKFFGTDGVRGVANEGLTPELAFKLGRFGGYVLTKDSERPRILIGRDTRVSGHMLEGALLAGLLSIGAEVMRLGVISTPGVAYLTKATSAQAGVMISASHNPVEDNGIKFFGPDGFKLTDAQENEIESLMEGEDNLPRPTGADIGVVNDYFEGGQKYLSYLKDTIDNDFEGIHIAIDCANGATSSLATHLFADLEADIYSIGSSPDGLNINDGFGSTHPEKLQEFVVEKNADIGLAFDGDGDRLIAVDEKGNLVDGDKIMFICAKYMHEIGMLRKDTVVSTVMSNLGFYKALENIGLNSNKTSVGDRYVMEEMRQNGYNLGGEQSGHIIFLDYITTGDGMLSAIQLVNVMRETGKPLSELADEMVVFPQVLKNVRVMDKNQALSSSVLLDEVDAVEKELGEDGRVLVRPSGTEPLVRVMVEAKTKEECEQYADRIVSVIEQHLGA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MED16_EMENI
Sequence: MPLIMEDGINVDDLFGESTSLELGLPTSTPTASTKGLAQRLDEMRLVGCCQKIAWSRLGCIASISQDSTRVNVRHLQCQQSDGKWLLSDETPLNQVSEVHAGHALVHLCWNDSGTELAVADSSGRVSIYSIPIALNSVNVTRQAAFDPDDDGAQIVGMMWLSQYRSVHSFYQAAKVQGRWAYSPFRRRPIGTFHPAHKGALLCITRSGVMKLLYQNPDGRWAEITTELKNTSYSDRLLTHAALVTTQAGILVATHSACQRISLYRVSIQWTPSQWDPTQQKQGSQQFPTPSFRLVHMKVEVPYNIPSSNRDAGENPDEQLPFTSSLYCLTSLHIILPASDNSAGSTPNPWIVAVFSIPTHAILPHPQPQIPASVIVRWQLETSLMTLHPRFDDVPSKKGNGQVKPKTVLRRLDDITSGRHVISVDQTEYGNVLAVSYDDSSIAFYDPKTMAAFDGIDDANTVTSLAQAGFHYPLEPSALHMSFSPSACLIVGLDNDGQTHLRIMEHSYGAENGHYDENKYSAAIASLTLAFCRGCGGEVNTDDILLILIRQLSPDAQTAFLNEVYRALSINCNFTTEQDKLMNHPYIPRALSIQAALGFKGKFRARNIASNVPWAIIQLRQAAMIYPSFFQYNKGVQGPEPHDPDVLRLVLGNTKWALDFSLYILNELFDLADDFESVSSDQEAFNQKLKTTTSLPLIILLSSMSRAFLRFICRGLRGIHAGYANAPLTGDSRVYYTEICQTLDASPVRTDVYEKLLAGVDSAVKHAYTGAGFGDNERPGPEKELLVSSRIPPVLVPAVSTILRQTVPAMRGEMDRLAIFMGDYGWLGFGNDARSELYRRERDVDIIKKTPIASRSGKGSGLGSVEAVMGLGARNGNGSQLSRRCVRCCEVSEAMYPPRSVLSFKMTLKLGHLRSCICGGMWNLEGGLPG
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 16, Mediator complex subunit 16.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 16 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CISD2_DANRE
Sequence: MVLESISKIIKIQLPAYLKKLPLPETIGGFARLTVSEWLRLLPLLGILALLGYLTIRPFLPKKKKQRDSLINLKIQKENPKVVNEIDIEDLRTPNVCYCRCWRSKTFPVCDKSHIKHNELTGDNVGPLILKKKTL
What is the function of this protein?
Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum.  Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity).
What are the official names of this protein?
CDGSH iron-sulfur domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the CISD protein family. CISD2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein.
Protein: DGTL1_BRASO
Sequence: MSVGMAAPRAPYSCDPDRSRGRLFAEPPSRTRSPFRRDCDRVIHSTAFRRLKHKTQVFVFHEGDHYRTRLTHSLEVAQIARALARQLGLDEDLTETLALAHDLGHPPFGHAGERALNRCMADHGGFDHNAQTLRIVTAFEQRYPDFDGLNLTWESLEGIVKHNGPLQGPVPAGIAEFNARFDLELWSYASLEAQVAALADDIAYDAHDIDDGLRAGLFTVDDLKEVPLLAAIIAEIDRHYPSLDDIRRGAELVRELISYLIAAVAGEAERRIEQAKPVSPHDVRRHAGPLVAFPADVAEHEATIKAFLWQRMYRHERVMRVMRDAERIVADLFGRYQQDGATLPAGWLDGCGGEGERARRISHFIAGMTDRFALTEHHRLFDSTPDLR
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.