Protein: EQXS_FUSHE
Sequence: MDASEPIAVIGSACRFPGGSDSPSKLWELLKEPRDLLSKVPPERYNADAFYHADATHHGTANVRHSYFLSEDPSSFDNNFFNIQPGEAEAIDPQQRLLMEVVYQGLCSAGQTIEGLRGSPTAVYVGVMCDDWSGIITRDLEVFPRYGATGMARSIMSNRISYFFDWHGPSMTIDTACSSSLVAVHQAIQTLRSGESEVAIAAGANLILTPGMYVAESKLSMLSPSGRSKMWDQDVDGYARGEGIAAVVLKPLSAAIRDNDHIDCIIRATGVNQDGRTPGLTMPSATAQADLIRSTYARAGLDINKAEDRPQFFHAHGTGTPAGDPREAEAISRAFYSPDNLSKDDKLYVGSIKTIIGHTEGTAGLASLIGTSLAIQSKVIPPNMHLDVLNPKVAPFYNNLEVPTSALEWPETRSGQPRRASINSFGFGGTNAHAIIEAYEPNAAARASGTLFSPLTFSASSEPSLRFLLMSYSEHLKLNPQIPLKDLAYSLQTRRSTLAYRVAITATTAENASKQLDAIVDGEQSSSINTRQLSKSSPKILGIFTGQGTQWPRMGARLLEESPFASKRLAELDDALSSLPADDRPTWTLREMILANADRSRVAEAAISQPLCTAVQVVLVDLLSQAGIQLSAVVGHSSGEIGAAYAAGLLTARDAIRVAYYRGLYAKLAQSPNGHKGAMMAVGTTFGDAADFCELEAFQGRIQIAAKNSPSSITLSGDKDAIIEAIEIFKDEGKFARQLKVDTAYHSSHVIPCAQPYLEAMNKCGIETATATKTQWYSSVHGGQIMHADSLTTSYWVDNMTSAVLFSPAVAQAWEEGGPYDLAIEVGPHPALKTPALDTIEAISEGRPPYTGVIARGKDDVQQFSTALGFIWTHLGPGSVAFEKFESVVSGSKDRPSFIQDLPNYPFDHAKQFMSMSRVSGWFNSIQEAPHPLLGRRCHDRETSHSVQWRNVLSHKEIPWLQGHQLQGQIIFPATGYISMAVEAIKILAEPSSLGLITIEDLNITRALAFVDEDASVETLFELRILSRSENEINAEFCCYSGIPHTHTATMSLNATAQIKASLGAPTSDKLSKTAVNDFDLRPVSVDRFYDFLARLGYNYSWPFRGTTSIRRKANFATGTLEDQSGSNWEDQLMVHPGMLDSSLQTTFAAFCCPGDERLWALHLPTSFRSITINPYFTSAGIGKQNSFTYQSVAIEERKASKVLVELNLLSEEAGDTFLQIEGMELVPFSPATPANDAVLFSRFDYRLAGPDGELTAAEYSFKPEDYKMALDCERIAFYYLRRLVETITPEERANTLLHYRHLVDWAAYVVPQVSNGGNPHIPASAQNDTHDDIQQLLKKHYERVDIRLLESVGENLPQVIRDSGNILEHMTKDGMLQDVYEQGFGLNLVNQYIAHMTAQIAHRYPRMNILEIGAGTGGSTREILPRLGSAFSTYTYTDVSGGFFDMAQDRFKDCADRMIFKTFDMNISPASQGFTEGAYDLVIASNVLHATLELEDMMKHVRSFLKPGGFLIILETVNNDCLRVGLPMGSLPGWWLGAEHGRQWGPTLTLPQWDSLLSKCGFGGIDTTTPPVHKILPGHVFCAQALDERIEILRSPMDHLATLPETKSTQLAIIGGQTLKVHRMCDQISRRLSSRYTSISRFHSIEEINETGLPESCTVLSLTELDEPLFTNMTSGKLDALKILWKQGGCILWITSGSRAENPHSYMTTGVGRCMRFEYPNITLQALDIKQISDRCPELIVDHLLRLEILDKWSKELRSDELLWSLEPEIYIEEDTTIIPRLYPYEAGNARYNAERRKVIKQADTKTDRVIFAECEGKWEIQHASPLHVARELPFSSDVSTRTIRITHLSPAIVNIVPGVSVMACAGVDTASNEPVIAVTHIAESPVSIPTGWCIHLDKLDPVKTLTAVSAVLIASSILERLAKGETLVVHDTPPHVRVALDKLAKTASVAIFYTSSDEAMSKLGARYIDRRSPLRVIKASLPKSASKFIDLSQDSDKNETSKVISMCLPWDYETIDTAHLFGLRNVAQQSAFEKDVSSSLKKAFEAFNSQLNTTASTNSVSLKETSNPIVDQVRFAILDCTDTPIQASVHPIDDGRIFRADKTFLLVGLTGELGQSLCKWMVEQGARNIVLTSRRPNVSEHFLDSFTETGATVKALPMDATNRSSIEACLETIKKTSPPIAGVVNGAMVLRDALFENMPYEDFIKVLNPKVLGSQLLDEMFYDTPLDFFIFFSSTTAVMGNSGQSNYIAGNMYMNALAAQRKKRGVAASSIDISSIIGLGYVERAEDLSEDTFIKMGYKPMSEQDLQKLFAEAIVLGRPDCHEVCELVTGVTPIYTDAQASDQYLKDVKFGHFLMERLDTQAYTGKTSTVPVRVQLADVKIRADAVAIIKESFIVRLRRVLAVGPDEVINEKVTLVEQGVDSLMAVEVRSWFIKELDVDIPVLKILGGMSVPDLVDECLDLLSPSILDVSSLEAGNAQAAKPTTVIPQTPTRVTPPESSQGTSDQDKPYTGSDSSHSPIGTPLTSWDRQDSSPPDKSDDAPNSTDILAPPRTFPNELSSIMSYGQAGFWFLNDYLVNKKAFNMAVMLKLTGPIRTQPLEKAVKLVAERHEILRTRFFWSEDGDERTPMQGINPPEMKLTVKTIADEEEAETELEHLHEENWELSSGEGVKVILLRLSDQVHFLLSGMHHIYLDGYSFSVFFKDLESAYINHRLPPLPVESQYRTFALQQRKAYEDGDLLKSIEYYRQNFPQEFAPIRPFPFASTGSRQLANEYSQHEAKLSIAPDVSAKIRQLARANRSTSFHVYLAALKILLFSLLPDAEELFIGIADANRGDKKFMGSLGFFLNVLPLRFQRGKPRSRVSSAIQSARDAVYGALQHSHLPFDVLLRELNVPRSDKHTPIFQVFMDYRQVVQERSSWGGCKLSDEKWCNAGTGYDIALEVTENINTDTLLSLRLQKQLYSEEHTQVLLRSYLNVLEYMIRGSDKTVDAAPAWSDHDLQVAVDAGKAPDYESKWQPTVSHQIDQVIQDNPDNIALKDGNGNVLTYVQMGNRIDAISKALIDAGTVQGTVVGVFQEPSTDWICSLLAIFKAGAVYVPLDLRNSIPRLASIVKASRPSVIITDSTTDEKVESIGAKFVTKLQLDGLNPMIHHDSIEINHAKAGYLAVILFTSGSTGEPKGLMMTHTNLLAYAEVSSKTFARADEDLVVLQQSPFSFDFSLDQTMAALTNGGCLYVVPASKRGDPDEISKIMVEESVTYTTATPSEYDLWLRYSAETLRQCTSWKYAFSGGEAMSYKLAREFGTLKLRNLHVFNGYGPAETTILSHRIDLKYTDPDLPDPLPAGYPLPGFAVCIVDNKMRPVPPGVQGEIVLGGPCIVSGYLNMPESTRDKFLPDTFFGTSGTVYRSGDRGRLCQDGLLFCDGRLEGNRMIKLRGFRVELDEVEKTIVSHSAGALSHAVVTVRGAEEGRYLVAHVVFAPDFPEKDREGTMRSLRQTLPLPPYMRPSAFQVLTDIPRTAHLKIDRKAIQDIPVQTTQSEVSEILTPSEQRLSELWRRVLPLDPGTLTHESDFFLIGGNSILLVKLQTLLRQVSWTAPKLVTLMGSSTLGAMAGVLEDCGPVNIIHWDEETKFPQDLQLTTPLRAAGKSTDITVLLTGSSGYLGRHLLSSLLNDHRVAQVHCLCRNLNDHQVVENPSSKVRVLQSDLAQHKLGLPDSTYSQLATEVDVIIHCAANRSFWDRYEALKADNLESTKELVKLVVSSGRAIPLHFLSSGAVIKYNSGLAPPADGGDGYVATKWASEAFLRQAVDSINLPVFSHRPVACESVQQSEEEDISILNELIQIVKLLGCRPSFDGVGGFVDVMPVNEVVEAIHKTGLNSQTEEGFCILEHKAHQRAYVKSFAAAVESDSDLSKIPCIPILEWFGRTKKAGFSYFLASQDLILGSQLFSRR
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of equisetin, a trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:23614392).  The PKS module of eqxS together with the enoylreductase eqxC catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the eqxS NRPS module (PubMed:23614392).  Activity of the Dieckmann cyclase domain (RED) results in release of the Dieckmann product intermediate (PubMed:23614392, PubMed:18652469).  Diels-Alderase eqx3 is involved in endo-selective Diels-Alder cycloaddition to form the decalin ring, leading to the production of N-desmethylequisetin also called trichosetin (By similarity).  Subsequent N-methylation is carried out by eqxD to give equisetin (PubMed:23614392).
What are the official names of this protein?
Equisetin synthetase eqxS, Equisetin biosynthesis protein S, Hybrid PKS-NRPS synthetase eqxS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.