PharMolix/UniProtQA huggingface dataset:
Protein: EFTU_PEDPA
Sequence: MAKEHYERTKPHVNIGTIGHVDHGKTTLTAAITKVLSEKGLAKASDYADIDAAPEEKERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLAHQVGVDYIVVFLNKTDLVDDDELVDLVEMEVRELLSEYDFPGDDVPVLRGSALKALEGDAEQEKVIMDLMDTIDEYIPTPERSTDKPFLMPVEDVFTITGRGTVASGRIDRGEIKVGDEVEIVGLKEDVTKTTVTGIEMFRKTLDVGEAGDNIGALLRGVNREDVVRGQVLAAPGSIQTHKKFKGEVYILSKDEGGRHTPFFSNYRPQFYFHTTDVTGVIELPDNVEMVMPGDNVTFTVELIEPVAIEKGTKFTVREGGHTVGAGVVSEIDD
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_SALPK
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLVEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKAGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RNPH_MYCSS
Sequence: MSRREDGRLDDELRPVRITRGFTSHPAGSVLVEFGETRVMCTASVTEGVPRWRKGTGQGWLTAEYAMLPAATHDRSDRESVKGRVGGRTQEISRLIGRSLRACIDLNALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLAAAEKLSDPRPLSCAIAAVSVGVVDGRVRVDLPYSEDSRAEVDMNVVATDTGTLVEIQGTGEGATFPRSTLDKLLDLALASCDQLFVVQREALDAPYPGALPEPTSPPKKAFGS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RLMG_SHEB8
Sequence: MTTQFSVAGVELELLRYPAQQESNLQAWDAADEHLLKSLIESEQAAVPTAIINDSFGALSCGVSKLNPSWPLCVETDARTSFLGTEQNHGRNQLPLDNLQWFTSRDTLPENLALVLMKLPKNLSYFAHQLTRLSQVLPAGTRILVAAKAKSINGALLDVFGNHLGPASASLAWKNTRVITCVSDGKPRPLAKEVTWAVPEYQLEISNLSNVFAANKLDIGARIMLENLPKGDFKSIVDLGCGNGVLGLRTAQLFPEADIHFIDDSEMAVASAKANWARNQLPADKGHFYWDDCMTHLPEEVQPDLVLCNPPFHQGEAITDHIAWQMFLDARRRLKDGGILHIVGNRHLAYHVKLQRLFKNCTTVASNGKFVILQAQKK
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_BURMA
Sequence: MTTVSPRPRMARRALDGVLLLDKPVGLSSNDALMRAKRLYQAKKAGHTGTLDPLASGLLPLCFGEATKFSQDLLEADKTYEATMRLGVRTTTGDAEGDVLDTRDVSCDEAAVRAALARFVGEIVQVPPMYSALKRDGKPLYEYARAGQTVEREGRTVTIRALALVSCALPDVTFRVTCSKGTYVRTLAEDIGEALGCGAHLTMLRRTGVGPLTLEHAVTLDALDAATQDERDARLAPVDALLSTFPCVKLDAALATRFLHGQRLKLSELAARPDAAEGGRVRVYDADDRLLGVARASEGVLAPERLVVTGA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: QUEG_LACGL
Sequence: MKSLKEEIQKLAADLNIQKIGFTKADDFEYLRASLIEQKEAGHTSGFEHKNLDERLQPKLSLEDAKTIISIGIAYPNKAEEKPEKTEYRRGSFSRGSWGEDYHHVLRRKLKELAEGIEKIAGDFNYTAMVDTGALVDVAVAARAGLGFVGKNGLLVSKEYGSWMFLGELVTNLDIEEDQPVDYGCGSCTRCVDFCPTKALLGDGRLNAQRCLSYQTQTRGVMPEEYREKIKTVIYGCDICQVVCPYNKGINSHFHPEMEPDPDLTNPELLPLLDLSNKEFANKFGNMAGSWRGKNPIQRNVVYALGNANDRSALPKLHDIAENDVRDYMVDAAEWAIEKLENKHRMRPRKR
What is the function of this protein?
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
What are the official names of this protein?
Epoxyqueuosine reductase, Queuosine biosynthesis protein QueG.
What is the protein family that this protein belongs to?
Belongs to the QueG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK14_DIOEL
Sequence: MIQPQTLLNVADNSGARELMCIRIIGAGNPRYAHIGDVIVAVIKEAVPNMPLERSEVIRAVIVRTCKELKRNNGIIIRYDDNAAVVIDQEGNPKGTRVFGAIPRELRQFNFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y315_THEKO
Sequence: MRKGSVKEVLAKIKYDPREKEEDYYVVIEHRGAYGGEKKIPVELIELGHGYFFVGEAQIPYHRILRVVRKDGKVIWETKKL
What are the official names of this protein?
UPF0248 protein TK0315.
What is the protein family that this protein belongs to?
Belongs to the UPF0248 family.
Protein: NU4M_ORNAN
Sequence: MLKILIPTMMLLPLISYSKKEWVWINSSIYSLLISSFSLLTLNQHMDLGLNFNMSFSADSLSSPLLILSCWLLPLMILASQFHLMKEPMAHKRTYLMLLVILQIALLMAFSAVELIMYYILFETTLIPTLIVIARWGNQTERLNAGLYFLFYTLLGSLPLLVALIFIQTQLGSLHILLLTLTPNPLQDNWSNDILWLACMLAFLVKMPLYGFHLWLPKAHVEAPIAGSMVLAAILLKLGGYGILRIIIILEPISKFMAYPFIIMATWGMIMTSSICLRQTDLKSMIAYSSVSHMGLVVAASLIQTPWGFMGATAMMIAHGLTSSMLFCLANTNYERIHSRTMLLVRGLQMVLPLMSSWWLLASLANLGLPPTINLIGELMVIITTFSWSNFTLILLGLNTVITAIYSFYMLITVQRGKLTSHSLSINPSFTREHMIMTLHLLPLILLTLNPKLILGLTYC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS7_RUMCH
Sequence: MPRKGHISKRDVLPDPIYGSKTVTKLINNVMYDGKKGIAQQICYDAFDIIKEKTGRDPLEVFEEAMANIMPVLEVKARRVGGATYQVPMEVRPDRRQALGLRWLVDYSRKRGERTMRERLSGEILDAINNMGGAYKKKEDTHKMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: MLTC_ESCF3
Sequence: MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLKSRSNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQSSRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: DAPE_BRUA2
Sequence: MTLPVNPVDNLAALIRCPSVTPAEGGALTALEKMLKLMGFSANRPVFSDDNTPDIENLYARKSGNGPHLMFAGHTDVVPPGDEKDWKHPPFAAEIEDGVMYGRGAVDMKGGIACFVAAVARHIEKHGNIKGSISFLITGDEEGPAVNGTVKLLEWAKQRGESWDASIVGEPTNPNALGDMIKIGRRGSLSGTITVHGVQGHAAYPHLAENPVRGIVTLVDSLLYPAFDEGTANFQASNLEVTTIDVGNKATNVIPNKATASFNIRFNDTWTAESLQAEIISRLERAARDNRLRQGRETPIKYELTWRERPSHVFLTHDEKLIGTLTASVEAVTGKRPELSTSGGTSDARFIKDYCPVVEFGLTGQTMHMVDERVALADLEGLTQIYERFIADFFG
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: TIGRB_DANRE
Sequence: MLTFALTIVRHGETQYNRDKLLQGQGIDTPLSDTGHQQAAAAGRYLKDLHFTNVFVSNLQRAIQTAEIILGNNLHSSATEMILDPLLRERGFGVAEGRPKEHLKNMANAAGQSCRDYTPPGGETLEQVKTRFKMFLKSLFQRMLEEHGSALSSAPSEADQPVIAGLADDGAQNVPVHALMVSHGAFIRISVRHLVEDLQCCLPAGLKMNQVFSPCPNTGISRFIFTIHREESVLRATRIQGVFINRKDHLEEVKNSD
What is the function of this protein?
Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate.  Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production.  Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death.  May play a role in mitophagy inhibition.
What are the official names of this protein?
Fructose-2,6-bisphosphatase TIGAR B, TP53-induced glycolysis and apoptosis regulator B.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion.
Protein: Y2112_JANMA
Sequence: MTDEVSNTAAADVRDNGQIVFDAGAIRVLAVLAEKEALTPDAYPMSINALTNGCNQLTSRDPVMALTEVDVQGILQELIADKFVAEVNQAGARVSKYEHRLRMKWSLEQDKLAVLTVLMLRGIQTAGEIRTRSGRLHEFATIADVEAALQFLIDKYPPLVARLPRAPGTKETRYAPLLSSEVFPEAGELPVAAASGVSRHDRIGQLEAEVSSLRDEVEALKAQFQQFKQQFE
What are the official names of this protein?
UPF0502 protein mma_2112.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: NTPPA_RHOPA
Sequence: MLGRPKLVLASGSPRRLALLNQAGIEPDALRPADVDETPIRGELPRACANRLARAKAEAALQSIQLDDDLRGSYLLAADTVVAVGRRILPKAELTDEASQCLRLLSGRNHRVYTAVCLVTPKEAFRQRLVETRVRFKRLSEEDIAGYVGSGEWRGKAGGYAVQGIAGSFVVKLVGSYTNVVGLPLYETISLLGGEGFPIRHGWLNAG
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_NEIMF
Sequence: MKVLVLGAGVAGVSSAWYLAEAGHEVTVIDRAKGVAMETSFANAGQLSYGYTTPWAAPGIPTKALKWLFKSHPPLLFRPDGSLYQIEWLWRMLQNCTAAHYQTNKERMVRISEYSREMFRRFEAQTGMNFEERKKGTLQIFRQTKEVEAAEQDIAVLERYGVPYRRLKPEECAEFEPALARVTAKIAGGLHLPADATGDCHLFTENLYKLCQEKGVQFHFNQTISRIDHNGLRIKAVETETGRFEADAVVCALGCFSRTVLAQLDLDLPIYPVKGYSLTLPVTNSDGAPVSTVLDESYKVAITRFDNRIRVGGMAELSGYEIKLPEKRRETLALVVNDLFPEGGDLSQALFWSGLRPMTPDSTPLIGRTRFENLFLNTGHGTLGWTMSLGSAKLTADIVSGKDTEIRSDDLSLSRYQA
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: RNF24_HUMAN
Sequence: MSSDFPHYNFRMPNIGFQNLPLNIYIVVFGTAIFVFILSLLFCCYLIRLRHQAHKEFYAYKQVILKEKVKELNLHELCAVCLEDFKPRDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQLHSKQDRGPPQGPLPGAENIV
What is the function of this protein?
May play a role in TRPCs intracellular trafficking.
What are the official names of this protein?
RING finger protein 24.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass membrane protein.
Protein: HISX_SALCH
Sequence: MSFNTLINWNSCSPEQQRALLTRPAISASDSITRTVSDILDNVKTRGDDALREYSAKFDKTEVTALRVTPEEIAAAGARLSDELKQAMAAAVKNIETFHSAQTLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPARIAGCQNVVLCSPPPIADEILYAAQLCGVQEIFNVGGAQAIAALAFGSESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPDADIARKVAEAVERQLAELPRADTARQALSASRLIVTKDLAQCVAISNQYGPEHLIIQTRNARDLVDAITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKAGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: KCS5_ARATH
Sequence: MSDFSSSVKLKYVKLGYQYLINNFLTLLLIPVIATVAIELLRMGPEEILSVLNSLHFELLHILCSSFLIIFVSTVYFMSKPRTVYLVDYSCYKPPVTCRVPFSSFMEHSRLILKDNPKSVEFQMRILERSGLGEETCLPPAIHYIPPTPTMESARNEAQMVIFTAMEDLFKNTGLKPKDIDILIVNCSLFSPTPSLSAMIINKYKLRSNIKSYNLSGMGCSASLISVDVARDLLQVHPNSNAIIISTEIITPNYYKGNERAMLLPNCLFRMGGAAILLSNRRSDRWRAKYKLCHLVRTHRGADDKSYNCVMEQEDKNGNVGINLSKDLMTIAGEALKANITTIGPLVLPASEQLLFLSSLIGRKIFNPKWKPYIPDFKQAFEHFCIHAGGRAVIDELQKNLQLSGEHVEASRMTLHRFGNTSSSSLWYELSYIEAQGRMKRNDRVWQIAFGSGFKCNSAVWKCNRTIKTPTDGAWSDCIERYPVFIPEVVKL
What is the function of this protein?
Mediates mostly the synthesis of VLCFAs from 26 to 30 carbons in length (e. g.  C20:1, C26, C28, C30).
What are the official names of this protein?
3-ketoacyl-CoA synthase 5, KCS-5, Eceriferum 60, Very long-chain fatty acid condensing enzyme 5, VLCFA condensing enzyme 5.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: SLYX_SHEB5
Sequence: MQGVQAQIEDLETKLAFQELTVEELNQEVIKLNRLVAHQQHQIHMLIGKLQDMEPSNMATQAEETPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: PNP_IDILO
Sequence: MNPITKQFQYGQHTVTLETGVIARQATASVLASIDDTTVLVTVVAKKEAREGQNFFPLTVNYQEKTYAAGKIPGGFFKREGRPSENETLTCRLIDRPIRPLFPDGFMNEVQVVATVVSVNPQINPDIVALIGTSAALSISGVPFAGPIGAARVGVVNDEYVLNPTADELENSKLDLVVAGTDKAVLMVESEAQLLSEDQMLGAVMYGHEAMQDVIKAITEFTAEAGKEKWDWQAPAKDESLQTKIRELAEQGIGEAYRTTDKAERKGKLDQVKEQMVEKLTAEDENVDLEESGKIFHDLESDIVRSRIIAGEKRIDGRDPDMVRAISVATGVLPRTHGSALFTRGETQALVTATLGTDRDAQMIDELTGMNTNRFMLHYNFPPYCVGETGMVGSPKRREIGHGRLAKRGIQAVMPSHDEFPYTIRVVSEITESNGSSSMASVCGSSLALMDAGVPIKSSVAGIAMGLVKEGDKHVVLSDILGDEDHLGDMDFKVAGNTDGITALQMDIKIDGITRDIMESALAQAKSARLHILKVMDEAIGGHREELSTYAPRFTTIKIDQDKIKDVIGKGGAVIRELTESTNTNIEIGDDGTIKVAASDQADADAAIEKIKQLTANVEVGKIYQGKVARIVDFGAFVTVLPGKDGLVHISQIAEERVNDVNEYLKVGDVVPVKVLEIDRQGRVRLSMKEAAEKKEEPAPEAPAEPAAEEENKSEE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VDAC2_HUMAN
Sequence: MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA
What is the function of this protein?
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity).  The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity).  The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).  Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432).  Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432).
What are the official names of this protein?
Voltage-dependent anion-selective channel protein 2, VDAC-2, hVDAC2, Outer mitochondrial membrane protein porin 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic mitochondrial porin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane. Membrane. Note=May localize to non-mitochondrial membranes.
Protein: FOLD_YEAST
Sequence: MAIELGLSRITKLLEHLGNPQNSLRVLHIAGTNGKGSVCTYLSSVLQQKSYQIGKFTTPHLVHVTDSITINNKPIPLERYQNIRLQLEALNKSHSLKCTEFELLTCTAFKYFYDVQCQWCVIEVGLGGRLDATNVIPGANKACCGITKISLDHESFLGNTLSEISKEKAGIITEGVPFTVIDGTNEASVINVVKERCKALGSELSVTDSQLNGNMIDTNSWGCFDLAKLPLNGEYQIFNLRVAMGMLDYLQMNELIDITKNEVSTRLAKVDWPGRLYRMDYRFDKVSNRTVPILMDGAHNGSAAVELVKYLRKEYGNQPLTFVMAVTHGKNLEPLLQPLLRPIDQVILTRFNNVEGMPWIHATDPEEIKDFILTQGYTKEIVIENDLHQVLPSLAHVSDEQRRPIVVCGSLYLCGELLRIHNSHLRN
What is the function of this protein?
Glutamate-adding enzyme which catalyzes the binding of the first glutamyl side chain to dihydropteroate.  Leads to the de nove synthesis of tetrahydrofolate.
What are the official names of this protein?
Dihydrofolate synthetase, DHFS.
What is the protein family that this protein belongs to?
Belongs to the folylpolyglutamate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_ACHLI
Sequence: MFERLEVMRKTYYALQEKLASGISDVKEITKLMKELKSLEDAVVAYEKYLSLKEQLKDLEELLELETESSVLEMAKAEEKSLESDIENLEESLRILLLPKDPDDDKNVIIEIKGAAGGDEGNIFAGDLFKMYSKYAESMGWKVTLVNTTPGSSGGFAGIEFIISGENAFSYLKHESGVHRVQRVPETESQGRIHTSTAVVLALPEQEDIEYDVKWEDIRFDTYNSSGAGGQSVNTTYSAVRLTHIPTNVVVTSQEERSQHANKDRAYKLLVTRIYDKIQQEQLEKEGESRKALIGRGNRSEKIRTYNYPQNRVTDHRIGLTINRLDAIMEGRIDLIIEPLINEIQKEALEGQSK
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_THEP3
Sequence: MLKGEKVVLAYSGGLDTSVIIPWLKENYECEIIAACINVGQGEELKYIKDKALASGASKVYIEDVKEEFVKDYIFPTLKAGAVYEGKYLLGTSMARPLIAKKLVEIAHKEGAKAIAHGATGKGNDQVRFEVSIHALDPSIKIIAPWRIWDLKSREDEIDYAKKKGIPIPATYEKIYSVDNNLWHVSHEGGDLEDPWNEPKSDLYDIITPPDKAPDKPEYVLIEFEKGIPVKVNGKALEPVKLIEELNAIAGRNGVGIADLVENRLVGMKSRGVYETPAGTLLYAAHKELEYLVLDKETMRFKDLVSQKYADLVYNGLWFSPLKAALDAFVEETQKNVTGVVRLKLYKGNVINAGVKSPYSLYNQEFVTFGKDEVYNQKDAEGFINLFGLSLKIKALMEMERKDMDEAVGR
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYF_MICAN
Sequence: MRTFNFLSFPQVHRQALVKAVLVAIATVSLLLTSDVINPQSAQAYPFWAQQTAPETPREATGRIVCANCHLAQKPAEIEIPHSVLPDSVFEAVVKIPYDPASQQVLGDGSKGGLNVGAVLMLPDGFKIAPPDRIPEEMQEKLGGVYFQSYKEGQDNVVIVGPLPGDQYKEIVFPVLAPDPSQNKGIHFGKYAVHLGANRGRGQVYPTGEPSNNNAFKASTAGTISQISKTEAGGYEVTITSEAGPVVENIPAGPELIVSEGQAIEVGQFLTSNPNVGGFGQKDTEVVLQNPGRIKGLVLFLGGIMLCQILLVIKKKQVETVQAAEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: HIS7_LEIXX
Sequence: MTNRTASLRRETSESGIELSLDLDGTGASEIHTSVPFYDHLLTAFAKHSLTDLRVRASGDTEIDVHHTVEDVGIVLGQAIRQALGDKAGLSRYGDALVPLDEALVQAVVDLSGRPYLVHAGEPSGFEFHLIGGHFTGSMVRHVFEAISFNAAITTHVTVVGGRDPHHIAEAEFKAFARAFRQAKAYDPLVSGIPSTKGAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYC_TADBR
Sequence: MPLNVSFANRNYDLDYDSMQPYFFCDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAFASFSPRDVDDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDGGGRSPARGQGACSTSSLYLQDLSAAVSECIDPSVVFPYPLNDSSSPKPCASPDSTAFSPSSDSLLSSAASSPRASPEPLALHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQPPAKRSESGSPSAGSHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPPTKRAKLDSGRVLKQISNNRKCASPRSSDSEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILAIQAEEQKLISEKDLLRKRREQLKHKLEQLRNSCA
What is the function of this protein?
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'.  Activates the transcription of growth-related genes.  Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis.  Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells.  Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).  Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
What are the official names of this protein?
Myc proto-oncogene protein, Proto-oncogene c-Myc, Transcription factor p64.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus.
Protein: NANK_VIBCM
Sequence: MRTLAIDIGGTKIALAIVEEGTIIQRYQIATPVVQDVTKFVQAILEKVTEWLPSIDYVGVSTTGYVTPEGITSINPETLNFPVPFPLAQTLEQLTNKPVSILNDAQAAAWFEFVQLKNPSLNMAFITVSTGVGGGIIIDGKLHKGNSGLAGHIGHMSVAIEGPLCGCGQRGCVESMASGNAIQKESEATFTETMSNVELFKQAAFNPKAEAIINRSVQAVATLCCNLKACLDLDIIVLGGGIGLAEGYLERLNKAIQSRPSVFHIPVTPAHGDYDACLLGAAFQFKE
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.