PharMolix/UniProtQA huggingface dataset:
Protein: PLCB_CAEEL
Sequence: MAKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLREGKLDEEDELNETPEVVGEDSVSPRSGGSGGTGAPEEVDDDTSDDDDDPSVQTSLNVMRTIPTVNTTSNNGSNRSARSSLDTPSPSGGSLMVPDRATSTATSIKNAVLARSPNFSSLRQKLSFKRRQSPLAGDQRAHPEVEQPVSSSSPATPSISGPPPCATSSGSTSSITITTTGCSTSSSGPSKHILGGEMPAKENDEAHPELKQNFIAKNLKGFGFSKKQPVLTKEEEERIFAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDPFVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDVPNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASSTIRSPNEQPQPVAVDKFKVDPIEVDDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQKQQPARRRNSSIAWIQTNVDKLITNNRRSTKKEKGSRRSLTASVSSGCGSASGTVTVSVCSPSGASCSGYSTGGPSTPVACNSDGTGSPATIGSPVPQDLVNNDRVRSLVNTQTGEWSAMVRRHDEEEFELKKVQLKEQFDLLRKLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQKHEEQLTKRHLDQLEQLDKDFHKALDAEVGNYKEEQLAAQPTSVV
What is the function of this protein?
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity).  Required in the nervous system to modulate neuronal activity.  Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion (PubMed:10571228).  Plays a role in efficient egg laying and defecation (PubMed:10571227, PubMed:10571228, PubMed:24212673).  Involved in axon regeneration after injury (PubMed:23072806).  Plays a role in male mating behavior by regulating spicule insertion and sperm transfer (PubMed:15958491).  By triggering Ca(2+) transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, regulates avoidance behavior in response to nose touch (PubMed:19730689).  By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in response to fungal infection (PubMed:19380113).  During embryogenesis, may play a role in epidermal morphogenesis together with plc-1 (PubMed:18369461).
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8, Egg-laying defective protein 8, Phosphoinositide phospholipase C-beta egl-8, Phospholipase C-beta egl-8, PLC-beta egl-8.
What are the subcellular locations of this protein?
Perikaryon. Cell projection, axon. Synapse. Cell junction, adherens junction. Note=Present in neuronal cell somas and axon processes of the nerve ring in head ganglia. Present in the adherens junction of intestinal cells.
Protein: REL_CHICK
Sequence: MAGISEPYIEIFEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNKTFPSIQILNYFGKVKIRTTLVTKNEPYKPHPHDLVGKDCRDGYYEAEFGPERRVLSFQNLGIQCVKKKDLKESISLRISKKINPFNVPEEQLHNIDEYDLNVVRLCFQAFLPDEHGNYTLALPPLISNPIYDNRAPNTAELRICRVNKNCGSVKGGDEIFILCDKVQKDDIEVRFVLDNWEAKGSFSQADVHRQVAIVFRTPPFLRDITEPITVKMQLRRPSDQEVSEPMDFRYLPDEKDPYGNKAKRQRSTLAWQKLIQDCGSAVTERPKAAPIPTVNPEGKLIKKEPNMFSPTLMLPGLGTLTSSSQMYPPCSQMPHQPAQLGPGKQDTLPSCWQQLFSSSPSASSLLSMHPHNSFTAEVPQPGAQGSSSLPAFHDNPLNWPDEKDSSFYRNFGSTNGMGAAMVSAADMQSASSNSIVHATHQASATAASIVNMETNDMNCTSLNFEKYTQVLNVSNHRQQLHQAPAACPPVAAPGSTPFSSQPNLADTAVYNSFLDQEVISDSRLSTNPLQNHQNSLTLTDNQFYDTDGVHTDELYQSFQLDTNILQSYNH
What is the function of this protein?
Proto-oncogene that may play a role in differentiation and lymphopoiesis.  NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.  NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52.  The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.  Different dimer combinations act as transcriptional activators or repressors, respectively.  NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors.  NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.  In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus.  The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator (By similarity).
What are the official names of this protein?
Proto-oncogene c-Rel, p68.
What are the subcellular locations of this protein?
Nucleus.
Protein: CCME_LEGPA
Sequence: MTPVRRRKLFILLFALSVLSAAAALVLYALRQNISLFYTPTQIVAGEAPAKHHIRVGGMVEANSIVRAKKGLDVQFKITDFENTIVVTYSGILPDLFREGQGIVAEGEVTDNHHFHATQVLAKHDANYMPPQVKSALADKVKQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: SDHA_CAEEL
Sequence: MLRAASNGLRNTVAARSVSLSAANHSDAKRSDIAQYKVVDHAYDAVVVGAGGAGLRAAMGLAEGGLKTAVITKLFPTRSHTVAAQGGINAALGNMNPDNWRWHFYDTVKGSDWLGDQDAIHYMTREAERAVIELENYGMPFSRTTDGKIYQRAFGGQSNDFGRGGQAHRTCCVADRTGHSLLHTLYGASLQYNCNYFVEYFALDLIMENGVCVGVIAMDLEDGTIHRFRSKNTVLATGGYGRAFFSCTSAHTCTGDGTALTARAGINNSDMEFVQFHPTGIYGAGCLITEGSRGEGGYLVNSAGERFMERYAPNAKDLASRDVVSRSMTVEIMEGRGVGPDKDHIYLQLHHLPAEQLQQRLPGISETAMIFAGVDVTKEPIPVIPTVHYNMGGVPTNYKGQVLNYTPKKGDEVVPGLYAAGECGAHSVHGANRLGANSLLDLVIFGRACAIDILKNTSAGVGVPELPKNAGEASVANIDKLRHNKGDISTAELRLTMQKSMQNHAAVFRRGDILKEGVKVLSKLYKDQAHLNVADKGLVWNSDLIETLELQNLLINATQTIVAAENREESRGAHARDDFPDRLDELDYSKPLEGQTKKELKDHWRKHSIIRSNIETGEVSLDYRPVIDTTLDKSETDWVPPKVRSY
What is the function of this protein?
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Flavoprotein subunit of complex II, FP.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: HSLU_COXBR
Sequence: MTMTPREIVAELDKFIIGQNDAKRAVAIALRNRWRRMQLGEELRREIFPKNILMIGPTGVGKTEIARRLSDLAGAPFLKIEATKFTEVGYVGRDVESIIRDLVDVAVKMTREKAIRQVKSLAEEAAEERVLDALIPPARGGFQGEPTAEEKPTEKKESATRQLFRKKLRNGELDDKEIEVEVSAHPSFEIMGPPGMEEMVSQLQGIMSSMSSRRSKSRRLKVKDALRILGEEEAAKLVDEDQIKSTALASVEQNGIVFIDEIDKIVKREGAVGADVSREGVQRDLLPLVEGSTVFTKYGMVKTDHILFIASGAFHIAKPSDLVPELQGRFPIRVELKALTADDFVRILTEPKASLTEQYTELLKTENFGLSFTKDGIKRLAEIAYQVNDRSENIGARRLHTIMERLLEEVSFEATDKQGESITIDADYVNKQLKKLAEDEDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBPS2_HUMAN
Sequence: MSNLKPDGEHGGSTGTGSGAGSGGALEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTARQPVGFVIFDSRAGAEAAKNALNGIRFDPENPQTLRLEFAKANTKMAKSKLMATPNPSNVHPALGAHFIARDPYDLMGAALIPASPEAWAPYPLYTTELTPAISHAAFTYPTATAAAAALHAQVRWYPSSDTTQQGWKYRQFC
What is the function of this protein?
RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856).  Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway.  Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity).
What are the official names of this protein?
RNA-binding protein with multiple splicing 2, RNA binding protein, mRNA processing factor 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUN1_HUMGT
Sequence: MARGTALLGLTSLLLGLVNGQKPGETKEVHPQLTTFRCTKKGGCKPATNYIVLDSLSHPIHRAEGLGWGNCGDWGNPPPKDVCPDVESCAKNCIMEGIPDYSQYGVTTNGTSLRLQHILPDGRVPSPRVYLLDKTERRYEMLHLTGFEFTFDVDATKLPCGMNSALYLSEMHPTGAKSKHNPGGAYYGTGYCDAQCFVTPFINGLGNIEGKGSCCNEMDIWEANSRASHVAPHVCNKKGLYLCEGEECAFEGVCDKNGCGWNPYRVNVTDYYGRGEEFKVNTLKPFTVVTQFLANRKGKLEKIHRFYVQDGKIIESFYTNKEGIPYTNMIEDEFCAATGSRKYMELGATQGMGEALTRGMVLAMSIWWDQGGNMEWLDHGEAGPCAKGEGAPSNVVQVEPFPEVTYTNLRWGEIGSTYQEVQKPKPKPGPGPRSD
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Endoglucanase EG-1, Cellulase, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPC9_DICDI
Sequence: MKIIKKDKEEIITNFEVLQLLKHKRRIEEQVLLNEFVNNVIRYLETTPASKQTIESVKECKKSVTKLADTSGCKILTGEMLQILNIAPSSEVEVHLVIEDCEDRIDAKEVLKEIKNSLGEEAVIRDEDNL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit rpc9, RNA polymerase III subunit C9.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GUAA_NEIMB
Sequence: MTQDKILILDFGSQVTQLIARRVREAHVYCELHSFDMPLDEIKAFNPKGIILSGGPNSVYESDYQADTGIFDLGIPVLGICYGMQFMAHHLGGEVQPGNQREFGYAQVKTIDSELTRGIQDGEPNTLDVWMSHGDKVSKLPDGFAVIGNTPSCPIAMMENAEKQFYGIQFHPEVTHTKQGRALLNRFVLDICGAQPGWTMPNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLNESKMVMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKIIGAEFIEVFDAEEKKLTNAKWLAQGTIYPDVIESAGAKTKKAHAIKSHHNVGGLPENMKLKLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGVRILGEVKKEYADLLRQADDIFIQELRNTTDENGTSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVIALRAVITSDFMTAHWAELPYSLLGKVSNRIINEVKGINRVVYDVSGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: HEXI1_RAT
Sequence: MAEPLLSEHQHQPQTSNCTGAAVVHEEQNSERPPSAEERVPKEDSRWQSRASLQSGSRPGQEGDGGLKHQLPPLQTNACPELSCLEKGEKGQNGEDLSTGGASPSAEGEPMSESLVQPGHDSEATKLEAPVAGVEEPWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYPKRAAAKSDDTSDEDFVEEAGEEDGGSDGMGGDGSEFLQRDFSETYERYHAESLQNMSKQELIKEYLELEKCLSRKEDENNRLRLESKRLGGVDARVRELELELDRLRAENRQLLTENELHRQQERAPPSKFGD
What is the function of this protein?
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor.  Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.  May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.  Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
What are the official names of this protein?
Protein HEXIM1, Cardiac lineage protein 1.
What is the protein family that this protein belongs to?
Belongs to the HEXIM family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear.
Protein: Y1031_METJA
Sequence: MIPMDVVLIVLILVLVGYFSKIFGILKEEHAKILNNIVIYIAMPSTIFLTISKNVSSSQILEFLKLPVVIFLCCLFVGILAYLLGKHIFKLKDEKLGGLILVSMLGNTGFLGYPVALGMFGEEGLARAIFCDLGGVFATMLLGTYVGIRFGKGRDKSILKDMAKFPPLITGILSIILVFFGFKLNYIPSFILKSLNYLSSATVPLIMMSLGLSLSPKALKFGVFWGIIASIFRFIVSPATAFTLSELINIKGLEKNVLLVESSMPSAMMTLVLGTLYELDIKLIASSIFITTTFSLLVIALWGWILLN
What are the official names of this protein?
Uncharacterized transporter MJ1031.
What is the protein family that this protein belongs to?
Belongs to the auxin efflux carrier (TC 2.A.69) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL20_BURA4
Sequence: MPRVKRGVTARARHKKIIKLAKGYRGRRNNVYRIAKQAVMRAGQYAYRDRRNKKRVFRALWITRINAAVRQHDMTYSVFINGLKKASIELDRKVLADMAVFDKAAFAAIVQQVKAAVAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: MTXH_METMA
Sequence: MFKFQKEQEIANIAGIKVGGQPGELPTVLAGTIFYNRHEIVEDAAKGLFDRDAAEKLVNLQESGSDTTGNPHMVHIFGTTAESITRYIDFIAEVSDSPFLIDSPEGPVRAHAAGYVSEIGLADRAVYNSINMSINTSEMKALEQSDIDSSIILGFNAKDSSLQGRMEMLETGAGLLEEGLLSIADRCGIVNKLIDPSITPMGNGAGIALRMTIAAKAKWGHPTGSGIHNAPSAWNWLNRQKEKDPVLYKICDIGSTCLQQAAAGDFILYGPIEYAEYVFPMAAMSDIMIAEAVADLDIEPVERHPINFLV
What are the official names of this protein?
Putative methyltransferase mtx subunit H.
What is the protein family that this protein belongs to?
Belongs to the MtrH family.
Protein: MURC_HYPNA
Sequence: MTTPTPFPVGPAHIVGIGGIGMSGIADVMLTMGYEVQGSDVSDSANVERLRARGVKVFIGHKPENVVGAGTVIISTAIRRDNPEVQAARAAGIPVVRRANMLAEITRLKYTVCVAGTHGKTTTTSLVACLLDGAGIDPTVINGGIIHAYGSNYKAGESDWMVVESDESDGTFAKLHPTCAIVTNIDPEHMDHYGTMDKLREAFDTFVENLPFYGFAVLCTDHPEVQALAARVTDRRRITYGFNLQADVRAVNLSTDLKGAHFDVEIRRGAGEAPRRIEGLTLPMAGEHNVQNALAAITVALELGASDEQISASLASFGGVKRRFTPVGEWLPAAGGEPVKIIDDYGHHPVEIAAVLKAARAMQADRTVIAVCQPHRYSRLKDLFEDFSRCFDQADHVLVAPVYEAGETPIPGITHETLVRSIQRNGHRSARALPSLAELPEVVKTLAGPGAMVVCLGAGDITRYAGELEARLKG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_STAAC
Sequence: MKDLPIIALDFESKEKVNQFLDLFDESLFVKVGMELFYQEGPQLINEIKERGHDVFLDLKLHDIPNTVGKAMEGLAKLNVDLVNVHAAGGVKMMSEAIKGLRKHNQDTKIIAVTQLTSTTEDMLRHEQNIQTSIEEAVLNYAKLANAAGLDGVVCSPLESRMLTEKLGTSFLKVTPGIRPKGASQNDQHRITTPEEARQLGSTHIVVGRPITQSDNPVESYHKIKESWLV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: RUVB_PROM5
Sequence: MAIISSSLDESNIPRSRKELRLVDSKIIADEKINKNLNIVRPTSFKEFIGQEQIKSSLKIAIDASKYRKEALEHTLLYGQPGLGKTTLALLISYEMNSKCRVASAPSIERPRDIVGLLLGLKEGEILFIDEIHRLNKLTEELLYSAMEDFRLDLTMGANRGARCRTINLPKFTLIGATTKLASISAPLRDRFGLCHKIEFYSNDELKQIIFNFSNLINLQLDSDACCSLAKISRGTPRIALRLLKRVRDYAQVMKKTNKISIEIIEKALDSQKIDNRGLDNVDRKFLSFLKLNNNNPIGLDSIAAGMGEESSMLEFVVEPYLIQIGFIMRTPRGRKLTSLGKKYISSNNEKY
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: QUEC_METPE
Sequence: MKAVCLLSGGMDSSTLAYVAKDMGYHIHALHLNYGQRTEKKELQSATAIARSLSAEEFIPLDLGYFKAFGKSSLTDPAIDVDVFDENRPELPNTYVPFRNANLLSIATSFAESRDADAIFIGVQALDYSGYPDCRPAFIQAFQQVMDLGTADGTHIDLLTPFIGLTKTDILRKGLDLGVPYEHTWSCYQNEEKACGVCGSCHFRQKAFAELGLSDPIPYEE
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, Archaeosine biosynthesis protein QueC, PreQ(0) synthase.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: THIL_ARCFU
Sequence: MFYANMKEFELIKLVERLFGDEDVITPAGKHDAAYVKIGNRLIVLTCDTVNEKSDFPPYMLPEEMGWMAIAVTLSDVAACGARPLYFLSSISLKSIEFFEDILLGIKRCADRFGVKVVGGDIDFSEITTIAGFAIGEARRHITRRGAKVGEGVFITDLPGKAQLCLEMLERGAKREELPYAEKLYTPVPRIEEGMRIARYASAMTDVSDSLAVSLHQISQSSNVKIVLDNIVLSHLSPAENALELFLYGGGDFELVYTAKSSDDGIRIGRVERGKGVFAEIDGKTFEVEFRGYSHF
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
What are the official names of this protein?
Thiamine-monophosphate kinase, TMP kinase, Thiamine-phosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-monophosphate kinase family.
Protein: RAD1_SCHPO
Sequence: MFQAETVCLKQIQSTLRCIDFSKECTIEITSRGLRFAVEESQSLQAHAFLDKSLFQTFNFQGDSDGDTYMFQTMISPLLQSLSIYTDGKERISTSAWDQPTVNIMHKRGVICKVQYNGPGCPFIWEVEEMAGYATACELLTMECEDDVDINRLASTLCTKIIMKSNWLYDALVELDNNMGENLIIHTSSQKSTFLLRCVGALSTTEIEYPNEKSVLESFETDSENTYSYRFSLIRHALKALQVGSKVNLRIDENGTLSIQIMLVGQEGLCTFVDFCIVPLDLVSEDEEEDEEEEPAESNQSDNNVLRNDPNYRGDAETEDEDS
What is the function of this protein?
Recombinational reparation of DNA damages induced by UV and gamma radiation.
What are the official names of this protein?
DNA damage checkpoint control protein rad1.
What is the protein family that this protein belongs to?
Belongs to the rad1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NDHJ_SOYBN
Sequence: MQGRLSSWLVKHGLIHRSLGFDYQGIETLQIKPEDWHSIAVILYVYGYNYLRSQCAYDVAPGGLLASVYHLTRLEYGIDQPEEVCIKIFVARKNPRIPSIFWVWKSADFQEKESYDMLGISYDNHPRLRRILMPESWIGWPLRKDYIAPNFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: SYT_BORBU
Sequence: MSKDLDKEDILYKKRHSIAHVMAEAVLDLFPNTKIAIGPPIKDGFYYDFEFKKQITEDSLLDIENRMREILKTGSSFEKEIISVEQALEIFKDEPYKIDLIKNFDLQNEVSIYKSHNFVDLCRGPHVENMNKIDPKAFKLTSIAGAYWRGSEKNPMLTRIYGTLWNNEKELRSYLNLREEIKKRDHRKLGKELDLFSIHEEIGPGLVFFHPNGAKIRALIEDFWREEHSKNGYDILFTPHIGKSWLWQTSGHLDFYKDSMFEKIEMDKSDYYLKPMNCPFHIAIYNTGKHSYRDLPFRWAELGTVYRYEKIGALHGMMRARGFTQDDAHIICTHSQVLDEIKEVLRFAIYMWSKFGFSNPKAYLSTKPDKSVGNDSDWEMSLKVLEETLSDFEVPYEIDKGGGAFYGPKIDLKIVDSLEREWQMSTIQFDFNLPERFNMTYTAEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPLWLSPVQVVIIPVNNIVEDYAIKVFNKFKNEGIRIKLDNSSSRMNAKIREYQAKKIPYMFIIGEREATEERISIRTRTNEQINGMKLDEALKFILFKIRDKEI
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_MYCBO
Sequence: MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAALRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPTAWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTLATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLETLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.