PharMolix/UniProtQA huggingface dataset:
Protein: COAE_PRB01
Sequence: MIIGLTGGIGSGKSAAADFFIDLGISVLDADQVAKEALSTNSPGYTDFISQFGEVYLNNNREVDRLKLRELIFSNPSKKKDLENIIHPIVRSAISNFIITSTSPYSIVMVPLIFETNSYKNYDKIITVDCDLELQIVRASSRDAQNKSQIKNIINKQASREERLSISDDVLINNSTLSDLKKQVNVLHTKYMELLNE
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3A_MOUSE
Sequence: MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGGSSGKAAGDETGAKVERADGYEPPVQESV
What is the function of this protein?
Component of the small ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).  May play a role during erythropoiesis through regulation of transcription factor DDIT3 (PubMed:10713066).
What are the official names of this protein?
40S ribosomal protein S3a, Protein TU-11.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: KN7F_ORYSJ
Sequence: MGAIGGDEVVQWDKMDGGEVVNGGGGGGVGKLERILVSVRLRPLSDKEIARGDPSEWECINDTTIISRSTFPDRPSAPTAYSFDRVFRSDCDTNEVYKQGAKEVALSVVSGINSSIFAYGQTSSGKTYTMTGITEYTVADIYDYIGKHEERAFVLKFSAIEIYNEVVRDLLSAENTPLRLWDDAEKGTYVENLTEVVLRDWNHLKELISVCEAQRKTGETYLNENSSRSHQILKLTIESSAREFLGKDKSTTLVASVNFVDLAGSERASQALSAGARLKEGCHINRSLLTLGTVIRKLSKVRNGHIPYRDSKLTRILQPSLGGNARTAIICTMSPARSHMEQSRNTLLFASCAKEVVTNAQVNVVMSDKALVKQLQKELARLESELRCPASYSSLESLVKEKDNQIRKMEKEIKELKLQRDLAQSRLQDLLQVVGDNHVHVSKQSSVSGRNFTFDVPQTCEDEQSTTESSEVVDSVQNFRFQGRRVAQREHKPQQAENNVQFTTPSRYSVSSPPFSGMLPTNRSDHLSQISNEDSDDICKEVRCIETNETGGNECLESSAVGSNSLQDPNAGSSMHINNDSNSSMNSRLRDESPVTLEQHLENVRKPFANIVKDLGSSTRNSSSSKVLGRSRSCRSLTGSSLFEDLEKDDCTPPNRSFIDFAGRPQNCQRRGSALNYDAESETLSRAGSMLSEITTTRDGLKANSSVAGDTEFTGIGEFVAELKEMAQVQYQKQLGHSGNGDLAEGTIRSVGLDPITDALQSPSRWPLEFEKKQQEIIDFWHACNVSLVHRTYFFLLFKGDPADSIYMEVELRRLSFLKDTYSNGAIASIPNTSLVSSAKKLQREREMLCRQMQRRLSIEERESMYTKWGVSLASKRRRLQVARCLWTETKDLEHVRESASLVARLIGLLEPGKALREMFGLSFAPQQFTRRSYNSWRYGRSSLN
What is the function of this protein?
Binds ATP/ADP in vitro.  Possesses low ATPase activity but high affinity for microtubules.
What are the official names of this protein?
Kinesin-like protein KIN-7F.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-7 subfamily.
Protein: FLHC_ENTCC
Sequence: MCGEKSLLQEIDEVNIAMGLISLGARMQVLESETSLSRRRLLRLYKELRGCPPPKGMLPFSEDWFMSWEQNIHSSMFYNIYLYLKKTEQGRSIEMLMKTYRLYLEQCSTCSDEKPVLGLTRAWTLLRFIDCGIISRKACSVCGGGFIVTTEFIKNPFTCSLCSPPSRALKKSQVSNTGLLGTFAAPEIMTA
What is the function of this protein?
Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhC.
What is the protein family that this protein belongs to?
Belongs to the FlhC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_STRT1
Sequence: MKLHELKPAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGVGLRPGFEGGQTPLFRRLPKRGFTNINAKEYTLVNLEQLNVFEDGTEVTPVVLKEAGIIRAEKSGVKVLGNGELTKKLTVKAAKFSKSAEAAITAKGGSIEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PUR9_BURCJ
Sequence: MIKQALISVSDKTGIVDFAKSLSDLGVKLLSTGGTAKLLADAGLPVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRDLPEHMQALEQHGIPTIDLLVVNLYPFVATIAKDDCTLADAIENIDIGGPTMLRSAAKNHRDVTVVVDPADYAVVLDEMKANGNTVGYPTNFRLATKVFAHTAQYDGAITNYLTSLTDELKHASRSAYPATLNLAFDKVQDLRYGENPHQSAAFYRDLAAPAGALANYRQLQGKELSYNNIADSDAAWECVKTFDAPACVIIKHANPCGVAVGNDSADAYAKAFQTDPTSAFGGIIAFNREVDEAAAQAVAKQFVEVLIAPSFSDAAKQVFAAKQNVRLLEIALGDGHNAFDLKRVGGGLLVQSLDSKNVQPHELRVVTKRHPTPKEMDDLLFAWRVAKYVKSNAIVFCGNGMTLGVGAGQMSRVDSARIASIKAQNAGLTLTGSAVASDAFFPFRDGLDVVVAAGATCVIQPGGSMRDDEVIAAADEHNIAMILTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: SUT42_ARATH
Sequence: MSLAVKDLSTASSSSSKAIPVKIIPLQYPDSTSSDPHCHSIPFNDFFSRWTAKIKRMTFFDWIDAIFPCFLWIRTYRWHQYFKLDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAVGPVALVSLLVSNALSGIVDPSEELYTELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYFLGYSVSRSSKIMPVIDSIIAGADQFKWPPFLLGCTILVILLVMKHVGKAKKELRFIRAAGPLTGLALGTIIAKVFHPPSITLVGDIPQGLPKFSFPKSFDHAKLLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSAVNSESEAKTGLSGLVTGIIIGCSLLFLTPMFKFIPQCALAAIVISAVSGLVDYEGAIFLWRVDKRDFTLWTITSTTTLFFGIEIGVLIGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNMKQYPEAYTYNGIVIVRIDAPIYFANISYIKDRLREYEVAIDKHTSKGPDMERIYFVILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRVHDAVQVCVHYVNRPTDVEESSKPSLWRRSGLKNSSTYTEVESNIVLEEPLLSREK
What is the function of this protein?
H(+)/sulfate cotransporter that may play a role in the regulation of sulfate assimilation.
What are the official names of this protein?
Probable sulfate transporter 4.2.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS4_METFK
Sequence: MSRFTGPRLKVMRALGIDLPGLSRKTIEARPTPPGQHGAKNTRRKKSDFGVKLQEKQKLRFNYGLSEKQLRRLMVDARKGKSPTGETLLQLLERRLDNVVFRAGFAPTIAAARQLVTHRHVMLNGKSVNIPSIRVRVGDEISLKASSTKLPIVVETLANPPLTRPEWISWAEQSQQAKVAHLPAAEDVPFPVDVQQVVEYYANRL
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: FENR_BACCZ
Sequence: MKVAENQKVYDITIIGGGPTGLFTAFYGGMRQASVKIIESLPQLGGQLSALYPEKYIYDVAGFPKVRAQELVDNLKEQMKKFDPTVCLEEAVDTLEKQADGIFKLVTNKQTHYSKSVIITAGNGAFQPRRLELEGTAKYEKKNLHYFVDDMNKFAGKRVVVFGGGDSAVDWTMMLEPIADKVTIVHRRDKFRAHEHSVESLMNSRAEVSTPYVPVELIGDDKIEQVVLQHVKTEEKIIIDVDDVIVNYGFVSSLGPIKNWGLDIQKNSILVNSKMETNIPGIYAAGDICTYEGKVKLIACGFGEAPTAVNNAKAYFDPNAKLQPMHSSSMF
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: LEUC_STRTD
Sequence: MSGKSIFDKLWDRHVITGDEGQPQLMYVDQHYIHEVTSPQAFQGLRDAGRKVRRPDLTFGTFDHNVPTVNIFDIRDAISKAQIDKLAENVIEFGIDNASHGSDKQGIVHMVGPETGRTQPGKFIVCGDSHTATHGAFGAIAFGIGTSEVEHVFATQTLWQVKPKKMLVEFTGKPQKGIYSKDYILALIAKYGVACGVGYVVEYRGEAIDRLTMEERMTICNMSIEFGSKMGIMNPDQTTYDYMRGRECVPEDFDAAVADWKTLVSDDDAEYDKVIRMDVSELAPMVTWGTNPSMGVDFDTPFPEVRDMNDERAYHYMGLRPGQKAEDINLGYIFIGSCTNARLSDLQLAARIVKGKKISPNLTAIVVPGSRPVKRAAEKIGLDKIFKDAGFEWREPGCSMCLGMNPDKVPDGVHCASTSNRNFEDRQGFGAKTHLCSPAMAAAAAIAGHFVDVRRMPEVQ
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: MUTS_PSYIN
Sequence: MTLSAQQLQQHTPMMQQFLTIKSEVPDTLLFYRMGDFYELFFDDARKASQLLGISLTQRGKTGGNAIPMAGVPYHSVEGYLAKLIAMGESIAICEQIGDPATSKGPVERKLVRIITPGTVTDEALLNDRQDNLLCSVYQLQNSFGIASLDLGSGRFIINQFQHTETLQAELQRLNPAELLYPENFEHMDLIEHLQTIRRRPEWEFELATSKKILNQQFSTKDLIGFGVEKAEVALCAAGALLQYIKDTQRTSLPHLQSIQLEKNIDSVILDAATRKNLELTQNLSGGFDNTLAEVLDFTVTPMGSRLLKRWIHQPIRNFNTLTYRQTMIQTLIEQDLSSALADPLKQIGDVERVIARLALRSARPRDLTRLRTAFSLLPELQHLIADLPTELVGKLNKEMGLYPELLTLLEKAVIDNPPVIIRDGGVIKEGYNEELDQWRNLAKGATDYLEQLETRERQATGISTLKVGYNRVHGYYIETSRSQSDIVPAHYIRRQTLKNTERYIIAELKEHEDKVLSSRGKALALEKKLYEQLIDLLLPHLQNLQSTAQALAELDVLNNLAERAVTLNYVRPTLQAENGIEIEEGRHPVVEQVSKTPFIANPVMLNDKRRMLIITGPNMGGKSTYMRQVALMVLMAHIGSFIPAQQAKIGPVDRIFTRIGASDDLASGRSTFMVEMTETANILHNATKNSLVLMDEIGRGTSTFDGLSLAWACAEQLAKKIQAYTLFATHYFELTKLPENIPELVNVHLDAVEHGDAIAFLHAVQEGAANKSYGLQVAALAGVPKEVVSNAKNILRQLELGSQPQANLNEKPLQTTLAFDDAQTNQALLLLANINPDELTPKKALELIYLLKERA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: TRMD_LEVBA
Sequence: MRIDVLSLFPDMFSGPMHDSIVGKAIENGHLTMPVTNFRDYSTNKHGNVDDYPFGGGAGMLLQPQPIFDALKATEEQAAAEGLPKGRVILLDPAGVTFNQHVAEDFAHEEHLTFLCGHYEGYDERIRTLVTDEVSLGDFVLTGGELASMVMIDATVRLLPGVLGNAESAPGDSFSSGLLEYPQYTRPADFRGMTVPDVLISGNHGKIEKWRQKEALRRTYQRRPDLIDHDQLTAEQKRLLADVRIEEEERASRN
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SL2C2_VIPAA
Sequence: AFCCPSGWSAYDQNCY
What is the function of this protein?
Regulatory subunit of the blood coagulation factor X-activating enzyme.  Activates coagulation factor X (F10) in a calcium-dependent manner by cleaving the Arg-Ile bond at position 234.  Weakly hydrolyzes insulin B chain, fibrinogen and some components of the extracellular matrix in vitro, but does not activate prothrombin or plasminogen.
What are the official names of this protein?
Snaclec factor X-activator 2 light chain 2, VAFXA-II LC2.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: MU130_SCHPO
Sequence: MICKYIYLAIFVFGTARIPKPSACLPGDFWKTKQEIEVQKKIDEFNQYRISALWSMVSKMEDPTLSGLDGRYIVVDQNQLYLSPISKKSEKLIFRFNLNHRGYLEVKSGFRAFIENKYSPLVFHATSWTNGFSIDVQKTNPISSYTPFVMQYLNSPWFSACRVESGNWQVFVGRMNMNEHEHCYPMSLIMKREDTWLRYYHKNNRNPIDWKLVQDCAMWPDGYPGTGRESEKGSNLEAITR
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 130 protein.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ADE_PSE14
Sequence: MYDWLNALPKAELHLHLEGSLEPELLFALAERNKIALPWNDVETLRKAYAFNNLQEFLDLYYRGADALRTEQDFYDLTWAYLLRCKEQNVIHTEPFFDPQTHTDRGIPFEVVLAGITGALKDGKSKLGVDSGLILSFLRHLSQEEAEKTLDQALPFRDAFVAVGLDSSEMGHPPSKFQRVFDRARSEGFLTVAHAGEEGPPEYIWEALDLLKIQRIDHGVRAIEDERLMQRIIDEQIPLTVCPLSNTKLCVFDDMAQHNILDMLERGVKVTVNSDDPAYFGGYVTENFHALYTHLGMTEDQAKRLAQNSLDARLVKP
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenine to hypoxanthine.  Plays an important role in the purine salvage pathway and in nitrogen catabolism.
What are the official names of this protein?
Adenine deaminase, ADE, Adenine aminohydrolase, AAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Protein: RUVB_LACJO
Sequence: MKDVNEEERIIGAESSEEDETIELSLRPQLLAQYIGQDKVKSEMKIYIKAAKQRDEALDHVLLYGPPGLGKTTLAFVIANEMGVHLKSTSGPAIEKAGDLVALLSELNPGDVLFIDEIHRLAKPVEEVLYSAMEDFYIDIVVGEGQTTHAVHVPLPPFTLIGATTRAGQLSAPLRDRFGIIEHMQYYSVEDLEKIIQRSSVVFNTKIDPEAAIELARRSRGTPRVANRLLKRVRDFAEVKGEEAISLVTTKHSLHLLEVDDEGLDQTDRKLLRMMIENYGGGPVGIKTIAANVGEDTDTIEEVYEPYLLQKGFITRTPRGRSVTQKAYLQLGYPPKDEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PHNW1_CUPPJ
Sequence: MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITGSLCEDLVRIVHGEGTHVCVPMQGSGTFSVEAAIANVVPRDGKVLVPQNGAYCQRILKICKVLGRAHVELPIPEDRPATAAAIEAALKKDPSITHVAQVHCETGAGVLNPLPEIAAVCARLGKGLIVDAMSSFGAIEIDARTMPFDALVAATGKCIEGVPGMGFVLVKKTVLEGSQGNSHSLALDLYDQYTYMQKTTQWRFTPPTHVVAAFRTALDQFLEEGGQPVRGERYRRNYETLVQGMAVLGFRPFLSPDVQAPIIVTFHAPADARYDFRTFYEKVRSRGYILYPGKLTQVETFRVGCIGAIDDNEMRNVVSAIGETLREMGISMQPEGRVRAA
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase 1, 2-aminoethylphosphonate aminotransferase 1, AEP transaminase 1, AEPT 1.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: RL30_SALAI
Sequence: MARLKVTQVRSEIGTKRNQRDSLRSLGLKRINDVVVKEDRPEIRGMIFTVNHLVKVEEVE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: PRMA_ECO45
Sequence: MPWIQLKLNTTGANAEDLSDALMEAGAVSITFQDTHDTPVFEPLPGETRLWGDTDVIGLFDAETDMNDVVAILENHPLLGAGFAHKIEQLEDKDWEREWMDNFHPMRFGERLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTSLCLQWLDSLDLTGKTVIDFGCGSGILAIAALKLGAAKAIGIDIDPQAIQASRDNAERNGVSDRLELYLPKDQPEEMKADVVVANILAGPLRELAPLISVLPVSGGLLGLSGILASQAESVCEAYADSFALDPVVEKEEWCRITGRKN
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_ENDTX
Sequence: MRSDQIKRGAVRAPNRCLLYSTGISPGDLDKPFIGIASSFTDLVPGHVAMRDLERYVERGIAAGGGVPFIFGAPAVCDGIAMGHSGMHYSLGSREIIADLVETVANAHMLDGLILLSNCDKVTPGMLMAAARLNIPAIVVTAGAMMTGMYDKKRRSMVRDTFEAVGQFQAGKITEKQLSELEMAACPGAGACQGMYTANTMACLTETMGMSMRGCATTLAVSAKKKRIAYESGIRVVALVKKDVKPRDILTLAAFKNAIVADMALGGSTNTVLHLPAIANEAGIELPLELFDEISKKTPQIACLEPAGDHYMEDLDNAGGIPAVLFAIQKNLAHSKTVSGFDIIEIANSAEILDEYVIRAKNPYKPEGGIAILRGNIAPRGCVVKQAAVSEKMKVFSGRARVFNSEDNAMKAILDNKIVPGDIVVIRYEGPAGGPGMREMLSPTSALHGMGLSDSVALLTDGRFSGGTRGPCIGHISPEAAADGAIVAINEGDTININIPERTLNVELTDDEIKARIGKVIKPEPKIKTGYMARYAKLVQSADTGAVLK
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: NACP4_HUMAN
Sequence: MPGEATETVPAIEQQLLQPQAETGSGTESDSDESVPELEEQDSTQVTAQVQLVVAAEIDEEPVSKAKQRRSEKKARKARFKLGLQQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYMVFGEAKIEDLSQEAQLAAAEKFKVQGEAVSNIQENTQTPTVQEGSEDEEVDETGVEIKDIELVLSQANVWGAKAVRALKNSNDIVNAIMELTM
What are the official names of this protein?
Putative nascent polypeptide-associated complex subunit alpha-like protein, Alpha-NAC pseudogene 1, NAC-alpha pseudogene 1, NACA family member 4, pseudogene.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: NTM1A_AILME
Sequence: MTSEVIEDEKQFYLKAKTYWKEVPPTVDGMLGGYGHISSIDISSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFGVVDMVDVTEDFLIKARTYLGEEGKRVRNYFCCGLQDFSPEPNSYDVIWIQWVIGHLTDQHLAEFLRRCKQGLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVHRIVRSAGLSLLAEERQENLPDEIYHVYSLALR
What is the function of this protein?
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved.  Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif.  Some of the substrates may be primed by NTMT2-mediated monomethylation.  Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1).  Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET.  Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
What are the official names of this protein?
N-terminal Xaa-Pro-Lys N-methyltransferase 1, Alpha N-terminal protein methyltransferase 1A, Methyltransferase-like protein 11A, X-Pro-Lys N-terminal protein methyltransferase 1A, NTM1A.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. NTM1 family.
What are the subcellular locations of this protein?
Nucleus. Note=Predominantly nuclear.
Protein: GCSP_SHEPC
Sequence: MTKQTLTQLEQHDLFLRRHIGPDSSQQQAMLNYVGAESLDDLTAQIVPESIRLSQELSIGDSCGEAEGIAYIRGLAKQNQVFKSYIGMGYYGTQVPNVILRNVLENPGWYTAYTPYQPEIAQGRLEAILNFQQVSMDLTGLDLASASLLDEATAAAEAMALAKRVSKAKKANIFFVADDVFPQTLDVVKTRAECFGFEVVVGPASEAVNHELFGALFQYTNRFGQITDFTELFAELRAKNVIVTVAADIMSLVLLKSPGAMGADVVFGSAQRFGVPMGFGGPHAAFFVARDEHKRSMPGRIIGVSKDARGNRALRMAMQTREQHIRREKANSNICTAQILLANMASFYAVFHGPDGLKTIASRIHRFADILAAGLQAKGVSLVNSTWFDTLSIKGLDVAAVNARALAAEMNLRFDADGTVGVSLDETTLRTDIDALFDVILGAGHGLDVAALDAQIVAQGSQSIPAALVRQDAILSHPTFNRYQSETEMMRYIKRLESKDLALNYSMISLGSCTMKLNAAVEMIPVSWPEFANMHPFCPLDQAKGYTQLIEELSSWLVNVTGYDAVCIQPNSGAQGEYAGLLAIKKYHESRGDAHRNICLIPQSAHGTNPASAQLAGMQVVVTACDKQGNVDLEDLKTKAAEVAENLSCIMITYPSTHGVYEESIREICDIVHQHGGQVYLDGANMNAQVGLTSPGFIGADVSHLNLHKTFAIPHGGGGPGMGPIGVKSHLAPFVAGHVVVKPGRVSDNNGAVSAAPYGSAGILPISWMYIKLLGSNGLKKSTQTALLNANYVMKKLSEHYPVLFRGRNDRVAHECIIDLRPLKEASGVTEMDIAKRLNDYGFHAPTMSFPVAGTLMIEPTESESKVELDRFIDAMVSIRAEIAKVESGEWPADNNPLHNAPHTMADIMDPEFDTRPYSREVAVFPSAAVRTNKFWPTVNRIDDVYGDRNLMCSCAPLSDYE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: CH10_NEIM0
Sequence: MTIRPLHDRVVVKRLEAEEKTASGIVLPGAAAEKPDMGEVIAVGAGKIGKDGARRPLDVKVGDKIIFGKYSGQTVKADGEELLVMREEDIFGIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1281_ARCFU
Sequence: MRVLILAENEFEDLELFYPLYRLREEGLEVKVASSSLEVRVGKKGYQVRPDLTYEDVKVEDYAGLVIPGGKSPERVRINERAVEIVKDFLELGKPVAAICHGPQLLISAMAVKGRRMTSWIGIRDDLIAAGALYEDRPVVVDGNVITSRMPDDLPYFCGELIKILKRY
What are the official names of this protein?
Uncharacterized protein AF_1281.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family.
Protein: GLMU_JANSC
Sequence: MQATPRPLALIVLAAGAGTRMNSDLPKPLHTLGSAPLVAHTIAAGASLEPARLVVITGHGADEVEAVLQDIAPEAVTARQTPQLGTGHAVLQAAAALEGFEGDAMVLYGDSPFFTSETLQAMRIARAAHDVVMLGFRPADPGRYGRLVMDGDTLRKIVEFKDATPEEREITFCNSGVLCADAATLMTLLAQLTNDNAAGEYYLTDVPELAGNAGLTATAIACDEAETIGINSRAELVRAEAQFQSQRRAALIEAGVTMQAPDSVHFALDTHIGRDAVIEPYVVFGADVTVESGAQIRAFSHLEGCHISAGAIVGPYARLRPGAEIGNNAKVGNFVEVKAADIAEGAKVNHLSYIGDATVGERANIGAGTVTCNYDGVMKHRTDIGADAFIGSDTMLVAPVTVGAGAMTASGSTITEDVPDGALALGRAKQVNKPGLATKLRARLKAIKDAKSKD
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAFA_HUMAN
Sequence: MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGGGAGGGGGSSQAGGAPGPPSGGPGAVGGTSGKPALEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGPGFAGGGGADDMGAGHHHGAHHAAHHHHAAHHHHHHHHHHGGAGHGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGSAGGAGFPREPSPPQAGPGGAKGTADFFL
What is the function of this protein?
Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435).  Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959).  Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435).  Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498).
What are the official names of this protein?
Transcription factor MafA, Pancreatic beta-cell-specific transcriptional activator, RIPE3b1 factor, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Maf subfamily.
What are the subcellular locations of this protein?
Nucleus.