PharMolix/UniProtQA huggingface dataset:
Protein: TBX36_CAEEL
Sequence: MNEPTYNYNDFLMPALADGQPDISIEISEITKKQWNQLIGIHEVVVYKDCRKLFPAAKFSVRGLDPALLYSVEICFDVLSPFTFSYNKKLEKWIPTKTPVNCQSSALSSMICETGDWFMNGDMDFGALNITSSHEKAKEKIEQNRIAVCLSSRTMYQIRVVLYEMQNDELIYLKETKFDEMIFITCTEYRGQVNRELKKSMNRFSRKRKYEISGTKCQRSKRPAKLPVESLDEKELKNAEKGIMSLLESSPSSPSYLYQYQYNSPQSIPSSIYDSLYPSSPEEYQMVHTFPQTDQLSPSFQTSPTVHYDFYNQQYYDNSFHENYFQSYNRL
What are the official names of this protein?
Putative T-box protein 36.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPF_BLOFL
Sequence: MRFSKMHGLGNDFVIIDSITQKVYFNSDKIRSLSNRFYGIGFDQLLVVEPPYDPNIDFHCRIYNADGSEVYQCGNGIRCVARFVCIKKLTNKQHIKISTDTYSMMLSVLDSEFISVNMGEPIFDPIKIPFFSTQYQKMYVLFVPNFTILCGVVSIGNPHCVILVEQVDLVPVTVLGSILENHHCFPKKANISFMQIISQNNIKLRVYERGSGETKACGSAACAAVAIGIQQGLLKKNISVQVNLPGGDLFISWKGLGYPLYMIGSATYIYDGCINL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYRD_PSESY
Sequence: MKTKQEKKARPGSIMRLLWSSHPWLTFFTLLTGLISGVASIAVVNVINQAIHEETFQRQSLFWFVGLSVVALLFRNGASLFPAYASMRIMTRLRIALCRKILGTPLEEVDRRGAPNVLTLLTSDIPQLNATLLIMPTILVESAVFLFGIAYLAYLSWVVFAITISLMILGVAMYLLFFMGGMKFTHKVRDEFTAFNEYTHALVFGLKELKLNGIRRRWFSRSAIQESSVRVAKYNYIERLWFTAAENVGQLTLSLLVGCLLFAAPMFAVIDAKTMSASVLAVLYIMGPLVMLVSAMPMLAQGRIACTRLADFGFSINEPHPEPETSDADNVLLLDHKKSWGSIQLKNVHMNYKDPQSSSGFALGPIDLTIHSGELVYIVGGNGCGKSTLAKVFCGLYIPQEGQLLLDGAAVTDDSRGDYRDLFSAVFSDFHLFNRLIGPDEKEHPSTDQAQTYLSTLGLEDKVKIEGLGYSTTTALSYGQQKRLALVCAYLEDRPIYLLDEWAADQDPPFKRFFYEELLPDLKRRGKTILIITHDDQYFQLADRIIKLADGCIVSDVKCAVEGKRA
What is the function of this protein?
ATP-driven efflux pump necessary for the secretion of syringomycin.  May specifically bind syringomycin and translocate it to the periplasmic space.  SyrD is also required for full expression of the syrB gene.
What are the official names of this protein?
ATP-binding protein SyrD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLAH_ECO55
Sequence: MNALTAVHNNAVDSGQDYSGFTLIPSAQSPRLLELTFTEQTTKQFLEQVAEWPVQALEYKSFLRFRVGKILDDLCANQLQPLLLKTLLNRAEGALLINAVGIDDVAQADEMVKLATAVAHLIGRSNFDAMSGQYYARFVVKNVDNSDSYLRQPHRVMELHNDGTYVEEITDYVLMMKIDEQNMQGGNSLLLHLDDWEHLDHYFRHPLARRPMRFAAPPSKNVSKDVFHPVFDVDQQGRPVMRYIDQFVQPKDFEEGVWLSELSDAIETSKGILSVPVPVGKFLLINNLFWLHGRDRFTPHPDLRRELMRQRGYFAYATHHYQTHQ
What is the function of this protein?
Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG).  Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Glutarate 2-hydroxylase, G-2-H.
What is the protein family that this protein belongs to?
Belongs to the glutarate hydroxylase family.
Protein: KSB_ARATH
Sequence: MSINLRSSGCSSPISATLERRLDSEVQTRANNVSFEQTKEKIRKMLEKVELSVSAYDTSWVAMVPSPSSQNAPLFPQCVKWLLDNQHEDGSWGLDNHDHQSLKKDVLSSTLASILALKKWGIGERQINKGLQFIELNSALVTDETIQKPTGFDIIFPGMIKYARDLNLTIPLGSEVVDDMIRKRDLDLKCDSEKFSKGREAYLAYVLEGTRNLKDWDLIVKYQRKNGSLFDSPATTAAAFTQFGNDGCLRYLCSLLQKFEAAVPSVYPFDQYARLSIIVTLESLGIDRDFKTEIKSILDETYRYWLRGDEEICLDLATCALAFRLLLAHGYDVSYDPLKPFAEESGFSDTLEGYVKNTFSVLELFKAAQSYPHESALKKQCCWTKQYLEMELSSWVKTSVRDKYLKKEVEDALAFPSYASLERSDHRRKILNGSAVENTRVTKTSYRLHNICTSDILKLAVDDFNFCQSIHREEMERLDRWIVENRLQELKFARQKLAYCYFSGAATLFSPELSDARISWAKGGVLTTVVDDFFDVGGSKEELENLIHLVEKWDLNGVPEYSSEHVEIIFSVLRDTILETGDKAFTYQGRNVTHHIVKIWLDLLKSMLREAEWSSDKSTPSLEDYMENAYISFALGPIVLPATYLIGPPLPEKTVDSHQYNQLYKLVSTMGRLLNDIQGFKRESAEGKLNAVSLHMKHERDNRSKEVIIESMKGLAERKREELHKLVLEEKGSVVPRECKEAFLKMSKVLNLFYRKDDGFTSNDLMSLVKSVIYEPVSLQEESLT
What is the function of this protein?
Involved in the biosynthesis of ent-kaurene diterpenoids natural products and in the production of gibberellins phytohormones (PubMed:17456599, PubMed:9536043).  Catalyzes the conversion of ent-copalyl diphosphate to the gibberellin precursor ent-kaur-16-ene (PubMed:17456599, PubMed:9536043).
What are the official names of this protein?
Ent-kaur-16-ene synthase, chloroplastic, Ent-kaurene synthase, AtKS, Ent-kaurene synthase B, KSB, Protein GA REQUIRING 2.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpse subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL19_SALNS
Sequence: MSNIIKQLEQEQMKQNVPSFRPGDTVEVKVWVVEGTKKRLQAFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVVDSIAVKRRGAVRKAKLYYLRERTGKAARIKERLN
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: NU6C_PLAOC
Sequence: MDLPGPIHDFLLVFLGSGLILGGLGVVLLTNPIYSAFSLGLVLVCISLFYIPSNSHFVAAAQLLIYVGAINVLIIFAVMFMNGSEYYNDFHLWTVGDGVTSLLCTSIFVSLITTIPDTSWYGVIWTTRSNQIIEQDLISNGQQIGIHLSTDFFLPFELISIILLVALIGAIAMARQ
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ERT1_ASHGO
Sequence: MMTVHRDKAAKRKKTNVACVNCSRSHVTCESQRPCTRCVKKGLEMSCVNAPRKRRKYLADVPEDQLPIPLKPADADAGPGMSERDGAAESGSKGPEHQFQDQGKIVHKPKFLSNAANLEYSTLSDIIHQDTLLNKIPVSLLYNGTDSPTPPSEALSGTHSASHGADVAGSRLSERPVHNVLNSMSSSRFVLRGLLGPQTDSILSSNVDLFKVHFPLVPQAVADGTLDFKRHSQGSMVAKKLRYDKSINQYYLSPACALPEVPNPNKHLCNGTVSFSLESRAPDEHQVLYRSDWPHSLRYGTPMEIYTLISEPFCHTSGFHSLLKYLHSRFHRHDLVEMCRSIAEFRPIFIASAVDLTEEDMIFMEQSYQRTLLEYDRFITQIGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDDNSVREYFKTFSKVAYKDFKGFEQMETCVLLSPIEGRTIECSCMWTWKRDVFGMPMMIVGHFLPVIAHPEPRDTDRLADSDFCISAGEGNPI
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes (By similarity).
What are the official names of this protein?
Transcription activator of gluconeogenesis ERT1.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IABF_STRLI
Sequence: MRTARFTLDPAFTVGAVNPRLFGSFVEHLGRCVYTGVFEPGHPTADAEGLRQDVLELVRELGVTAVRYPGGNFVSGYKWEDSVGPVEDRPRRLDLAWRSTETNRFGLSEYIAFLKKIGPQAEPMMAVNLGTRGVAEALELQEYANHPSGTALSDLRAEHGDKDPFGIRLWCLGNEMDGPWQTGHKTAEEYGRVAAETARAMRQIDPDVELVACGSSGQSMETFAEWEATVLKETYDLVDHISLHAYYEPHDGDVDSFLASAVDMESFIENVVATCDHVGARLKSKKKINLSFDEWNVWYMTKTQAEVSALDWPEAPRLLEDNYSVMDAVVFGSLLIALLRHADRVTVACLAQLVNVIAPIMTEPGGPAWRQTTFFPFSQASKYGRGEVLDVRVDSPTYDTAKYGEADLLHATAVVRARRSVTVFAVNRSRTGALPLEVALSGLELTEVVEHSALADADPDARNTLAEPERVVPHPVDGTSLRDGRLTAALEPLSWNSIRCADPAPGQPPRRPGEGTGFTGTPPAAPPSSSSAPRPDPTARRSPDRTARARVLAAARVRRMPFGRTKVCGAPVRPPTYAPRFQPFRKTWTRWAPAPRSGSPSRRSPTEASIPGGTSSRNVVRYQVTPWRRSPPGSAPGTPAPTRRRRTRAGASRGAPRTARRC
What is the function of this protein?
Involved in the degradation of arabinan and is a key enzyme in the complete degradation of the plant cell wall.  Catalyzes the cleavage of terminal alpha-(1->5)-arabinofuranosyl bonds in different hemicellulosic homopolysaccharides (arabino-oligoxylosides, branched and debranched arabinans).  It acts rapidly on the short-chain arabino-oligoxylosides from digestion of xylan with xylanases.  It hydrolyzes slowly arabinan and arabinoxylan from wheat and rye flour.
What are the official names of this protein?
Intracellular exo-alpha-(1->5)-L-arabinofuranosidase, ABF, Alpha-L-AF, Arabinoxylan arabinofuranohydrolase, Intracellular arabinan exo-alpha-(1->5)-L-arabinosidase, Arabinosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSTF6_ARATH
Sequence: MAGIKVFGHPASTATRRVLIALHEKNVDFEFVHVELKDGEHKKEPFILRNPFGKVPAFEDGDFKIFESRAITQYIAHEFSDKGNNLLSTGKDMAIIAMGIEIESHEFDPVGSKLVWEQVLKPLYGMTTDKTVVEEEEAKLAKVLDVYEHRLGESKYLASDHFTLVDLHTIPVIQYLLGTPTKKLFDERPHVSAWVADITSRPSAQKVL
What is the function of this protein?
Involved in camalexin biosynthesis by probably catalyzing the conjugation of GSH with indole-3-acetonitrile (IAN).  May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
What are the official names of this protein?
Glutathione S-transferase F6, AtGSTF6, AtGSTF3, GST class-phi member 6, Glutathione S-transferase 1, AtGST1, Protein EARLY RESPONSE TO DEHYDRATION 11.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Phi family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: URE3_SYNSC
Sequence: MHLSPQEKDKLLIVTAALLAERRLNRGLKLNHPEAVAWLSFLVLEGARDGKSVAELMQEGTTWLRQDQVMEGVPELVHEVQMEAVFPDGTKLVTLHDPIR
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSC2_HUMAN
Sequence: MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNSPPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
What is the function of this protein?
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400, PubMed:35772404).  Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059).  May also play a role in microtubule-mediated protein transport (By similarity).  Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
What are the official names of this protein?
Tuberin, Tuberous sclerosis 2 protein.
Protein: VPRL_VILV1
Sequence: MEEVPRRQPGGLVEAEGVFQVYEDWECWDYVSQRVPDERLQRWLAMLTNNQLRRQVIREAQIWIWKHKGAAVRRNCGCRLCNPGWGSQVRNVEL
What is the function of this protein?
Seems to function as a Vpr-like protein, since it mediates host cell cycle arrest in G2 phase.  Cell cycle arrest creates a favorable environment for maximizing viral expression and production (By similarity).
What are the official names of this protein?
Probable Vpr-like protein, Protein S, Protein Tat.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: ABLB2_PHYPN
Sequence: MRSVFYVALVFAVLARSSTVAAFPHTDESQLLAVTSPDSATHTKRSLRAAGQEVVQSTGNGNGGIFKSTLTSINKVVHKPEIKLGGLIEKAKIAQAAKAFKNKATGKK
What is the function of this protein?
Secreted effector that associates with calmodulin to interfere with plant defense-associated calcium signaling in hosts.
What are the official names of this protein?
RxLR effector protein PPTG_18954, Avrblb2-like effector PPTG_18954.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell.
Protein: RL21_ROSDO
Sequence: MFAVLKTGGKQYKVQAGDMLRVEKLAADAGETVQFNEVLMLGGENTVVGAPFVKDAGVQAEVVDQIKGEKVINFVKRRRKHSSKRTKGHRQKLTLVKVTDILASGADKSGVKAAMGAGSVSATAVAAAAPKPTKKAAPAKAEKAEAAPAAGADDLKKLSGVGPALEKKLIEGGVTSFAQIAAWTEADVAAMDEKLSFKGRIEREGWIEQAKELAKG
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: IMDH_CHLP8
Sequence: MDKILYDALTFDDVLLVPAYSNVLPKETVVKSRVTRNIEVNLPLVSAAMDTVTEAELAIALARAGGIGIIHKNLSIDVQARHVAKVKRFESGIIRNPITLFEDATIQEAIDLMLRHSISGIPVVERPTPEGCLLLKGIVTNRDLRMTTSSNEKITTIMTTDLITAQEDIDLLAAEEILMQNKIEKLLVIDEEGYLKGLITFKDIQKRKQCPDACKDMHGRLRVGAAVGIRSNTITRVDALVEAGVDVVAVDTAHGHSQAVLDMVATIKEKYPELEVIAGNVATPEAVRDLVKAGADAVKVGIGPGSICTTRVVAGVGMPQLTAIMNCAKEAAKTDTPIIADGGIKYSGDISKALAAGADTVMMGSIFAGTDESPGETILYEGRRFKAYRGMGSLGAMSEPEGSSDRYFQDASAETKKYVPEGIEGRIPAKGPLDEVVYQLIGGLKSSMGYCGVKNIEELKKNTRFVRITSAGLRESHPHDVMITREAPNYSTSH
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: FGFR2_NOTVI
Sequence: MFSWSYLMGLVMVATATLSLARPSYNIAEDTTLEPEDANSSGDDEDDNDGSEDFTNDNNHMRAPYWTNTEKLEKKLHAVPAANTVKFRCPAGGNPTPSMRWLKNGKEFKQEHRIGGFKVRSQHFSLIMESVVPSDEGNYTCIMENEYGSINHTYHLDVVERSPHRPILQAGLPANTTTKVGGDAEFVCKVYSDAQPHIQWIRHFELNGSKIGPDGHPYLKVLKAAGVNTTDKEIEVLYVRNVSFEDAGEYTCLAGNSTGISYHTAWLTVLPDEERELDSSSEYTEIAIYCVGGFLITCMIGTIMVCHMKGRGKKSDFSSPPAVHKLSKSLPLRRQVTVSADSSSSMNSNTPLVRITTRLSSNNDTHLLAGVSEYELPEDPKWEYPREKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKDAATVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRTRRPPGMEYSFDINRIPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTETNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPGNCTNELYTMMTDCWRAVPSQRPTFKQLVEDLDRILTQTTNEEYLDLNNPLEQYSPSYPDTRSSCSSGDDSVFSPDAMPYDPCLPKSQHTNGTIKT
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development.  Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development.  Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development.  Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts.  Phosphorylates PLCG1, FRS2 and PAK4.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation.  Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling.  Over-expressed FGFR2 promotes activation of STAT1 (By similarity).
What are the official names of this protein?
Fibroblast growth factor receptor 2, FGFR-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded (By similarity).
Protein: AURZ_GIBZE
Sequence: MSPHSDTQETSHEATVTGQPDTLVCLTITAYKKPSLSEKEYRHHMTKVHAKLVSPLMEEYGIVRYTMTHNTKETRPMLYQLYDPQFSNQSDYDCIVQFIFKDIKDFLRMKADPRFLEKVAPDHVNFADTKRSTMTVGYYEEFVNDGKVVPKD
What is the function of this protein?
Dehydratase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655).  The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488).  The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881).  The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488).  Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488).  Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
What are the official names of this protein?
Dehydratase aurZ, Aurofusarin biosynthesis cluster protein Z, Gibberella pigment protein 6.
What is the protein family that this protein belongs to?
Belongs to the tpcK family.
Protein: SPEA_PSEAE
Sequence: MAARRTRKDDGSNWTVADSRGVYGIRHWGAGYFAINDGGNVEVRPQGADSTPIDLYELVGQLREAGLSLPLLVRFPDILQDRVRKLTGAFDANIERLEYQSRYTALYPIKVNQQEAVVENIIATENVSIGLEAGSKPELMAVLALAPKGGTIVCNGYKDREFIKLALMGQKLGHNVFIVIEKESEVQLVIEEAANVGVQPQVGLRVRLSSLASSKWADTGGEKAKFGLSAAQLLSVVERFRQAGLDQGVRLLHFHMGSQIANLADYQHGFKEAIRYYGELRALGLPVDHIDVGGGLGVDYDGTHSRNASSINYDIDDYAGVVVGMLKEFCDAQGLPHPHIFSESGRALTAHHAVLITQVTDVERHNDDVPKIVDLDEQPEIVRWLAELLGPTDAEMVTETYWRATHYIGDAAAQYADGKISLAQKALAEQCYFAICRRLHNQLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWAIGQVLPILPLHRLGEEPDRRAVLQDLTCDSDGKITQYVDEQSIETSLPVHEVKEGEDYLIGVFLVGAYQEILGDMHNLFGDTDSVNVYQRADGGIYHAGIETHDTIEDMLRYVHLSPEELMTLYRDKVAGAKLTARERNQYLDALRLGLTRSAYLS
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: PEN3_ARATH
Sequence: MWRLRIGAKAGDDPHLCTTNNFLGRQIWEFDANAGSPAELSEVDQARQNFSNNRSQYKACADLLWRMQFLREKNFEQKIPRVRIEDAKKITFEDAKNTLRRGIHYMAALQSDDGHWPSENAGCIFFNAPFVICLYITGHLDKVFSEEHRKEMLRYMYNHQNDDGGWGIDVESHSFMFCTVINYICLRIFGVDPDHDGESACARARKWIIDHGGATYTPLFGKAWLSVLGVYEWSGCKPIPPEFWFFPSYFPINGGTLWIYLRDTFMAMSYLYGKKFVAKPTPLILQLREELYPQPYAEIVWSQARSRCAKEDLYYPQSLVQDLFWKLVHMFSENILNRWPFNKLIREKAIRTAMELIHYHDEATRYITGGAVPKVFHMLACWVEDPESDYFKKHLARVSHFIWIAEDGLKIQTFGSQIWDTAFVLQVMLAADVDDEIRPTLIKGYSYLRKSQFTENPPGDYINMFRDISKGGWGYSDKDQGWPVSDCISESLECCLIFESMSSEFIGEKMEVERLYDAVNMLLYMQSRNGGISIWEAASGKKWLEWLSPIEFIEDTILEHEYLECTGSAIVVLARFMKQFPGHRTEEVKKFITKGVKYIESLQIADGSWYGNWGICFIYGTFFAVRGLVAAGNTYDNCEAIRRAVRFLLDIQNGEGGWGESFLSCPNKNYIPLEGNKTDVVNTGQALMVLIMGGQMDRDPLPVHRAAKVLINSQMDNGDFPQQEIRGVYKMNVMLNFPTFRNSFTLWALTHYTKAIRLLL
What is the function of this protein?
Converts oxidosqualene to tirucalladienol.
What are the official names of this protein?
Tirucalladienol synthase, Pentacyclic triterpene synthase 3, AtPEN3.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: YUAH_ECOLI
Sequence: MFQADAYGGYRALYESGRITEAACMAHARRKIHDVHARAPTDVTTEALQRISELYAIEVAVRGCSAEQRLAARKARPAPLMQSLYDWIQTQMKTLARHSDTAKAFAYLLQ
What are the official names of this protein?
Uncharacterized protein YuaH.
Protein: NFUA_COLP3
Sequence: MITISENAQQHFIKLLSQQAEGTHIRVFVVNPGTAKAECGVSYCPPDAVEADDIQLPFEGFSAMVDADSKGFLEDAEIDFTTDQMGSQLTLKAPNAKLRKVADDAPLFERVHYFLQAEVNPQLAGHGGECTLVEITDDGYAVLQFGGGCNGCAQIDVTVKDGIEKQLIELMAGEIKGVKDATEHERGDHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: GRPE_STAAN
Sequence: MTNKDESVEKNTESTVEETNIKQNIDDSVEQAEESKGHLQDEAIEETSDENVIEEIDPKDQKINELQQLADENEEKYLRLYAEFENYKRRIQKENEINKTYQAQRVLTDILPAIDNIERALQIEGDDETFKSLQKGVQMVHESLINALKDNGLEVIKTEGEAFDPNIHQAVVQDDNPDFESGEITQELQKGYKLKDRVLRPSMVKVNQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.