PharMolix/UniProtQA huggingface dataset:
Protein: ABC3G_SAGLB
Sequence: MKPQTRNTVVRMDPDTFFYDFYNRPILSDRNTVWLCYEVKMKTNDRSRPPLVAKILEGQVHFDPEHHAEMYFLSWFRGNLLQACKSSQITWFVSWNPCLNCVAKVAEFLAEHPNVTLTVSTARIYCYWKKDWRRALRKLCQTGARVKIMNYKEFAYCWENFVYKERKPFRYWDKFSGNYRFLRCKLQEILRHLMDPGTFTYNFTNDPSVLGRHQTYLCYEAEHLHSGTWVPLHQHRGFILNEASNNLSFPEGRHAELCLLDLISFWKLDPAQTYRVTCFISWSPCFSCAQEVAEFLHENPHVNLRIFAARIYDYRPGYEEGLLRLSWAGAPISMMKYSGFSHCWDTFVDHQGRSFKPWKGLNEHSQALSGRLQAILQIMGN
What is the function of this protein?
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility.  After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA.  The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.  Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA (By similarity).
What are the official names of this protein?
DNA dC->dU-editing enzyme APOBEC-3G, Deoxycytidine deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic, small amount are found in the nucleus.
Protein: FMT_AFIC5
Sequence: MPLRLIFMGTPDFAVPTLRELHAQGHEIAAVYTRAAKPAGRGMKLQITPVEKAARELGLPVLTPSTLRTPEAEAEFRAHNADAAVVVAYGMILPANILNAVPRGCFNLHASLLPRWRGAAPIQRAIMTGDAESGVMVMKMDVGLDTGDVAMTDRLQITDAMTAQDLHDALAPRGARLMAQAMVALEQGSLNLKPQGEEGVTYAAKIGKAEAKIDWARPAHDVLRHIHGLSPFPGAWFEVAIDGAPVRIKVLRCELVKGSGAPGALLDDRLTIACGEGAIRLLDVQRAGKQPMRALDFLRGTPLIPPLSVM
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: Y593_CHLPN
Sequence: MAFKRKTRWLWQVLILSVGLNMLFLLLFYSAIFRKDIYKLHLFSGPLIAKSSRKVYLSEDFLNEISQASLDDLISLFKDERYMYGRPIKLWALSVAIASHHIDITPVLSKPLTYTELKGSSVRWLLPNIDLKDFPVILDYLRCHKYPYTSKGLFLLIEKMVQEGWVDEDCLYHFCSTPEFLYLRTLLVGADVQASSVASLARMVIRCGSERFFHFCNEESRTSMISATQRQKVLKSYLDCEESLAALLLLVHDSDVVLHEFCDEDLEKVIRLMPQESPYSQNFFSRLQHSPRRELACMSTQRVEAPRVQEDQDEEYVVQDGDSLWLIAKRFGIPMDKIIQKNGLNHHRLFPGKVLKLPAKQS
What are the official names of this protein?
Uncharacterized protein CPn_0593/CP_0155/CPj0593/CpB0616.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0593/CT_474/TC_0759 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RUVA_NITWN
Sequence: MIGKLKGVIDSYGEDYVILDVGGVGYQVHCASRTLQALPSPGQAAVLSIETYVREDQIKLFGFRTDHEREWFRLLQTVQGVGARVALAVLGTLSPADLASAIALRDKASVARTPGIGPKVAERIVTELKDKAPSFANVDPTVVHLAGDLDDQRAPRPVRDAISALVNLGYGQPQATAAIAAASRGAGENAETAQLIRLGLKELSK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: TRPB_LISMF
Sequence: MTYQAPDENGFYGKFGGRFVPETLMKAVKELDEAYRASKTDPAFQKELNYYLKEYVGRETPLYFAEQLTAHAGGAKIYLKREDLNHTGAHKINNTIGQALLARQMGKQKVVAETGAGQHGVATATVAALFNMECTIFMGEEDVKRQSLNVFRMELLGAKVVSVKAGSRTLKDAVNEALRFWVANVEDTHYIMGSVLGPHPFPEIVRDYQSVIGIEARKQHLEKEGKLPDAIVACVGGGSNAMGLFYPFVDDVSVQMHGVEAAGHGLETEFHAATISKGEIGILHGAMMDVLQDENGQILEAFSISAGLDYPGIGPEHSFFRDLGRAAYHSVTDDEAVEAFQLLCRTEGIIPALESSHAISYAVKLASQMRPEESMVVCLSGRGDKDVNQLKERLEGQIND
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: FABPH_RAT
Sequence: MADAFVGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDTITIKTHSTFKNTEISFQLGVEFDEVTADDRKVKSVVTLDGGKLVHVQKWDGQETTLTRELSDGKLILTLTHGNVVSTRTYEKEA
What is the function of this protein?
FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
What are the official names of this protein?
Fatty acid-binding protein, heart, Fatty acid-binding protein 3, Heart-type fatty acid-binding protein, H-FABP.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCAD_ECOSM
Sequence: MSTYTRPVMLLLSGLLLLTLAIAVLNTLVPLWLAQEHMSTWQVGVVSSSYFTGNLVGTLLTGYVIKRIGFNRSYYLASFIFAAGCAGLGLMIGFWSWLAWRFVAGVGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYVGTFLGQLLVSKVSTELMSVLPWVTGLTLAGILPLLFTRVLNQQAENHDSTSITSMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLNHKGVSNASIGFWMAVLVSAGILGQWPIGRLADKFGRLLVLRVQVFVVILGSIAMLSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFTAMLMQNFSDNLLFIMIASVSFIYLLMLLRNAGHTPKPVAHV
What are the official names of this protein?
Uncharacterized MFS-type transporter YcaD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PGAM5_XENLA
Sequence: MYLRRALIAGGSAAAAILGVVAAGKSKGGSDSEILSVAPPATGQWDRNWDRREPISMVNLSKINAETGEEELQLHLNKHKPKATRHIFLIRHSQYKLDGKTDFDRVLTPLGREQADLTGQRLASLGHKYNHIVYSTMTRAKETTEIISKYLPDVNKSSSDLLREGAPIRPEPQVCHWKPDFVYYEDGPRIEAAFRHFIHRADPKQEEDSYEILICHANVIRYVVCRALQFPPEAWLRISLNNGSITYLVIRPNGNVSIRMLGDSGFMPAEKISRT
What is the function of this protein?
Displays phosphatase activity for serine/threonine residues.  Has apparently no phosphoglycerate mutase activity.  May be regulator of mitochondrial dynamics (By similarity).  May be a central mediator for programmed necrosis (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase PGAM5, mitochondrial, Phosphoglycerate mutase family member 5.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: Y041_RICTY
Sequence: MLLNIANLVGKHTIKFAQSVGIFALFSFIAISSIIKPPLYLSLIMRQLLFIGFHSLPVVAMTTFFSGAVLALQSYTGFSRFSAENSIATVVVLSLTRELGPVLAGLIVAGRVGASIAAEIATMKVTEQVDALYTLSTDPIKYLVCPRVIAAIITMPCLVLIGDVIGVMGGYLVGIYKLNFNSTAYLTSTFQYLELIDVISGLVKATVFGFIISIISCYSGYYSGKGAKGVGRATTSAVVNSSILILISNYLITELLFKV
What is the function of this protein?
Could be part of an ABC transporter complex.
What are the official names of this protein?
Probable ABC transporter permease protein RT0041.
What is the protein family that this protein belongs to?
Belongs to the MlaE permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KDSA_SHEHH
Sequence: MSNKIISLGSIEIANDKPFVLFGGMNVLESRDLAMQIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEIKSTFNLPLITDVHEVQQCAPVAEVVDVIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEIMLCERGSSFGYNNLVVDMLGMDEMKQTGYPVIFDATHALQRPGGRSDSAGGRRAQATELARSGMALGLAGLFIEAHPDPDNAKCDGPCALPLHQLENYLTQMKAVDDLVKSFEPIDTSK
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_PARL1
Sequence: MATTEKTKALVLFSGGQDSTVCLASVLARYDEVETVGFDYGQAHAVELGCRAKLRDALTRFPGWGAKLGPDHMIALPELGRISETALTRDVEIEMGENGLPTTFVPGRNLLFFTYAAALGYRRGASVIVGGMCETDYSGYPDCRADTIAALERAICLGMDRAFTLETPLMRIDKAATWALAHELGGDALVDLIIEETHSCYRGDRSKRHDWGYGCGTCPACELRARGYTAYLAGKA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: MCM8_MOUSE
Sequence: MSGAYRGRGFGRGRFQSWKRGRGGGNFSGRWRERENRVDLNEASGKHASAQASQPLLQQSTLDQFIPYKGWKLYFSEVYSNNSPFIEKIQAFEKFFTRHIDLYDKDEIERKGSILVDFKELTKADEITNLIPDIENALRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNGGETMVNVPHIYARVYNYEPLTHLKNIRATCYGKYISIRGTVVRVSNIKPLCTNMAFQCAACGEIQSFPLPDGKYTLPTKCPVPACRGRSFAPLRSSPLTVTLDWQLIKIQELMSDAQREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIVKVSNSEEGSRNKNDKCMFLLYIEANSVSNSKGPKAQTAEDGCKHGTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSATVTRVLSQDSNTSVLEVVSEKPLSERLKVAPGEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERTYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQTM
What is the function of this protein?
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR).  Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity.  Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs.  The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression.  However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (By similarity).  Probably by regulating HR, plays a key role during gametogenesis (PubMed:22771120).  Stabilizes MCM9 protein (By similarity).
What are the official names of this protein?
DNA helicase MCM8, Minichromosome maintenance 8.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to nuclear foci. Localizes to double-stranded DNA breaks. Binds chromatin throughout the cell cycle.
Protein: PST2_YEAST
Sequence: MPRVAIIIYTLYGHVAATAEAEKKGIEAAGGSADIYQVEETLSPEVVKALGGAPKPDYPIATQDTLTEYDAFLFGIPTRFGNFPAQWKAFWDRTGGLWAKGALHGKVAGCFVSTGTGGGNEATIMNSLSTLAHHGIIFVPLGYKNVFAELTNMDEVHGGSPWGAGTIAGSDGSRSPSALELQVHEIQGKTFYETVAKF
What are the official names of this protein?
Protoplast secreted protein 2.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
What are the subcellular locations of this protein?
Secreted.
Protein: PEMT_BOVIN
Sequence: MTRLLGYVDLSEPHFVAAVLAIVFNPLFWNVVARWEHKTRKLSKAFGSPRLACYTLGGAILLLNVLRSHCFTQAMLSQPRMQSLDNPAVYHVGLALLGVGGVFVLSSFLALGFTGTFLGDYFGILKEARVTMFPFSVLDNPMYWGSTAIYLGWAIVHASPTGLLLTALVALIYMVAIVYEEPFTAEIYQQKASQAYKRS
What is the function of this protein?
Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PEAMT, PEMT, Phospholipid methyltransferase, PLMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria.
Protein: USPD_SHIFL
Sequence: MAYKHIGVAISGNEEDALLVNKALELARHNDAHLTLIHIDDGLSELYPGIYFPATEDILQLLKNKSDNKLYKLTKNIQWPKTKLRIERGEMPETLLEIMQKEQCDLLVCGHHHSFINRLMPAYRGMINKMSADLLIVPFIDK
What is the function of this protein?
Required for resistance to DNA-damaging agents.
What are the official names of this protein?
Universal stress protein D.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_RICPR
Sequence: MAVKIRLARGGAKKRPFYRVVIANATAPRDGDFLEKVGTYNPMLASDNSERVILKKDRIEYWLGTGAKPTERVAKFIEKAGVTLPKKVKKEMEVKAKNRKVRPSKKQSKES
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: CT51_CONPL
Sequence: MRCVPVFVILLLLIASTPSVDARPNPKDDVPLASFHEDANGILQMLWKKGRSCCPSPTSCCPWGKRK
What are the official names of this protein?
Conotoxin Pu5.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: URED_PSEPF
Sequence: MNLPVATALFTPSWHAELELAYARFGDCTRPTRRRHLGPLRVQKHLYAEGPEVCQHIIVHPPGGIAGGDRLDISARVAQGAWAQITSPGAAKWYRAAGPAYQSLNLHVADGATLEWLPQETIVYSAAQAELTTSIELEGDARLFYWDVVALGRPASGERFDLGHFQAHLDIRRDGRLLWHERQRIVGADGLLDSPIGLDGHPVFATLLVTGEIDAELLERCRSLGHEVRGDLTQLPGLLVARCLASEALLARAWLIDLWRLLRPALLGREALPPRIWNT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_ECO57
Sequence: MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ANTE_BACSU
Sequence: MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLPSALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL
What are the official names of this protein?
Protein AntE.
Protein: COX2_BOSJA
Sequence: MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTIRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLYYGQCSEICGSNHSFMPIVLELVPLKYFEKWSASML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y4054_YERPA
Sequence: MLIIISPAKTLDYQSPLATTKFSQPEMLDKSQALIEICRELTPAQISSLMGISDKLAGLNAARFSEWQPDFTPANARQAILAFKGDVYTGMQAESFSEADFDFAQQHLRMLSGLYGLLRPLDLMQPYRLEMGTKLANPRGKDLYAFWGDQITEKLNQALELQGDNILINLASDEYFKAVKPAKLSGSLIKPVFLDEKNGKYKIISFYAKKARGLMSRFIIQNKLTKPEQLVDFNLEGYEFDAGLSAKNELVFKRAEQH
What are the official names of this protein?
UPF0246 protein YPA_4054.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: IF2_HAEIE
Sequence: MLRLMRQKKLSIQRRTKTTVSSTTTGGKSKEVQVEVRKKRTVKTDIAQQEEAKLKAQQEAEAKKIAEQKAIEEKARLEAEKVAAKKEADEKVKAETAKPVKSAVDSKVKSVDPEKEKRKAEEAELRRKAEELARQKAEEQARRAAEEAKRYAEADDSDNESSSEDYSDYNLSSRYALEAEDEEDRRNENRGRGKNKVAKAKKGGRDDENSKNSKNERESNRKNQKDAKFGKGKNGKKGAALQQAFTKPAQVVKSDVVIGETITVAELANKMAVKATEIIKMMMKMGEMVTINQVIDQETAQLVAEELGHKVILRNENELEEAVLGDRDVNAEKVTRAPVVTIMGHVDHGKTSLLDYIRKAKVAAGEAGGITQHIGAYHVEMDDGKMITFLDTPGHAAFTSMRARGAKATDIVVLVVAADDGVMPQTIEAIQHAKAAGAPLVVAVNKIDKPEANLDRVEQELLQHDVISEKFGGDVQFVPVSAKKGTGVDDLLDAILLQSEVLELTAVKDGMASGVVIESYLDKGRGPVATILVQSGTLRKGDIVLCGFEYGRVRAMRDENGKEVDEAGPSIPVELLGLSGVPAAGDEATVVRDEKKAREVALYRQGKFREVKLARQQKAKLENMFSNMSEGDVAELNVIVKADVQGSVEAIVQALNELSTNEVKVKVVGSGVGGITETDATLATASNAIIVGFNVRADATARRVIEAENIDLRYYSIIYELLNEIKAAMSGMLEPEFKQEIIGLAEVRDVFRHPKFGAIAGCMVTEGVVKRNNPIRVLRDNVVIFEGELESLRRFKDDVSEVRNGMECGIGVKNYNDVKVGDQIEVFEVVEVKRSI
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_SHIDS
Sequence: MPVLHNRISNDALKAKMLAESEPRTTISFYKYFHIADPKVTRAALYQLFTALNVFGRVYLAHEGMNAQISVPASNVETFRAQLYAFDPALEGLRLNIALDDDGKSFWVLRMKVRDRIVADGIDDPHFDASNVGEYLQAAEVNAMLDDPDALFIDMRNHYEYEVGHFENALEIPADTFREQLPKAVEMMQAHKDKKIVMYCTGGIRCEKASAWMKHNGFNKVWHIEGGIIEYARKAREQGLPVRFIGKNFVFDERMGERISDEIIAHCHQCGAPCDSHTNCKNDGCHLLFIQCPVCAEKYKGCCSEICCEESALPPEEQRRRRAGRENGNKIFNKSRGRLNTTLGIPEPTE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: PP2BB_MOUSE
Sequence: MAAPEPARAAPPPPPPPPPPLGADRVVKAVPFPPTHRLTSEEVFDMDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHTTENHGTGNHSAQ
What is the function of this protein?
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (By similarity).  Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (By similarity).  Dephosphorylates and activates transcription factor NFATC1 (By similarity).  Dephosphorylates and inactivates transcription factor ELK1 (By similarity).  Dephosphorylates DARPP32 (By similarity).  Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (PubMed:26029823).  May play a role in skeletal muscle fiber type specification (PubMed:12773574).
What are the official names of this protein?
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit beta isoform, CNA beta.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIP11_ARATH
Sequence: MEGKEEDVRVGANKFPERQPIGTSAQSDKDYKEPPPAPFFEPGELSSWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRALYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHSWDDHWVFWVGPFIGAALAALYHVVVIRAIPFKSRS
What is the function of this protein?
Water channel required to facilitate the transport of water across cell membrane.  Its function is impaired by Hg(2+).
What are the official names of this protein?
Aquaporin PIP1-1, AtPIP1;1, Plasma membrane aquaporin-1, Plasma membrane intrinsic protein 1a, PIP1a.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.