PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_MYCPA
Sequence: MRLPAGRHIRSIDAPIVPQSGRADTLDTLANRRLAGPDQEIPISSFADKTFTAPAQIRNFCIIAHIDHGKSTLADRMLQLTGVVDERSMRAQYLDRMDIERERGITIKAQNVRLPWQVSGGEDAGKEFVLHLIDTPGHVDFTYEVSRALEACEGAVLLVDAAQGIEAQTLANLYLALDRDLTIIPVLNKIDLPAADPDRYAGELAHIIGCEPDDVLWVSGKTGEGVARLLDEVVRQVPPPQGQADAPLRAMIFDSVYDIYRGVVTYVRVVDGKITPRERIAMMSTGATHELLEVGIVSPEPKASDGLGVGEVGYLITGVKDVRQSKVGDTVTSARHGAQEALTGYREPKPMVYSGLYPVDGSDYPDLRDALDRLRLNDAALTYEPETSVALGCGFRCGFLGLLHMEITRERLEREFDLDLISTSPNVVYRVIKEDGTEIVVTNPSDWPEGKVRTVYEPVVKTTIIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYTMPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEAQLVKVDILLQGEAVDAFSAIVHKDAAFAYGNKMTTKLKELIPRQQFEVPVQAAIGSKIIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVDVPQEAFVAALSADAAGDKSKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PSBC_TRACE
Sequence: METLFNGTLALVGRDQESTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVLDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGIGAFLLVFKALYFGGVYDTWAPGGGDVRKISNLTLSPSILFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICIFGGIWHILTKPFAWARRALVWSGEAYLSYSLAAISVFGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLATSHFVLGFFFFVGHLWHAGRARAAAAGFEKGIDRDFEPVLSMTPLN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RLMH_BIFA0
Sequence: MNIDIVCVGKVKERYLRDAIDEYRKRLSRFAKVDVIEVADEKTPEHASDTLNAQIKEKEGERILKHLRDGAFVVALAIEGDQLTSEQLAARIAQWGLHGVSHLQFVIGGSLGLDPRVLRRANMPLSFSKMTFPHQLMRVILLEQIYRAFKINAHEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_DELAS
Sequence: MAKVALIQRELKREKLAAKYAAKYAELKAIAADAKRSDEERDAARLGLQKLPRNANPTRQRNRCEITGRPRGTFRQFGLGRAKIRELAFAGDIPGVTKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RS19_MICAN
Sequence: MGRSLKKGPFVAGHLMEKIEKLNAQGSKQVIKTWSRASTIIPDMVGHTIAVHNGKQHVPVYVSEQMVGHKLGEFAPTRTFRGHAKSDKKAGRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: MT1_HOMAM
Sequence: PGPCCKDKCECAEGGCKTGCKCTSCRCAPCEKCTSGCKCPSKDECAKTCSKPCSCCXX
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.  The different forms of lobster metallothioneins may have different biological functions.  Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions.  Binds 6 metal ions.  Known to bind cadmium.
What are the official names of this protein?
Metallothionein-1, CuMT-1.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 3 family.
Protein: BFSP1_CHICK
Sequence: MYRSSFLREVRKEKYERSDAYDELRGSPEFDSLAQAQGLENLQELNERFASYINRARVLEQRNTILRKQLETFQRMDELVGLDEAFAGQIEFNRQRMRELASDRAKLEREEKDAQRMLDEYHNKYRNEREYQQKLKETLERLNKEADEALLCNLELQIESQFLQDDINATKDRYKKNLMEIQTYVNILQQIIQTTPRVSPITTGISEEKLVAERRIPVLQSQLEEYKSILCQLQAQKYKLQTETTMLEQAIKNTQESYDDEIQLYNEQIENLRKGIEEAERTLEKYTTDCRQLVIYQQSLENELERYKRIIENEDSRLNSAIAGTPVTLFTQIYRPVQPQASRGRDITQAMQEIASVKPRQKALTKKLSRKKEIMSKDITDGLSPEKLYERTVEVFDQDQLEFRHEGSVTCEPGQEELELVEKEAVPEDVPDGAQISKAFDKLCNLVKEKIRVYKRPEAKVDSHPKGRYVLVTGEEGYEEPCFSSIPAGGGITVSTSNGKVTIGGDVEPIPELPEPSEPSEKEKRDICERRDEFETQDKLKEEEKEDLFEWGKIRGKIEQVTKYPDVSEPEAVPSPGLISPAEPGVLQETDHDREDKQGLLFREAGLPGSVSYEKVEVVESIEKFSDDRIQTYEETAMIVETMIEKTSKKKPGDKGS
What is the function of this protein?
Required for the correct formation of lens intermediate filaments.
What are the official names of this protein?
Filensin, Beaded filament structural protein 1, Lens fiber cell beaded-filament structural protein CP 95, CP95.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Protein: PO2F1_PIG
Sequence: MNNPSETSKPSMESGDSNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLGHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSALCSPSALNSPGLGVEGLNRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVGTTPSLVTSSAATTLTVNPVLPLTSAAVTNLSVTGTTDTTSNNTATVISTAPPASSAVTSPSLSPSPSASGSTSEVSSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPGLMAPSQFAAGGALLSLNPGTLGGALSPALMSNSTLATIQALASGGSLPITSLDATGNLVFGNAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSGPVASLHATSTSAESIQNSLFTVASASGAASTTTTASKAQ
What is the function of this protein?
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.  Modulates transcription transactivation by NR3C1, AR and PGR.
What are the official names of this protein?
POU domain, class 2, transcription factor 1, NF-A1, Octamer-binding protein 1, Oct-1, Octamer-binding transcription factor 1, OTF-1.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y091_NPVOP
Sequence: MVFLFTLLNYIIIILLTLWLLTSLKQNIETKPPLPSPTPTPTPSPTPTPTPSPTPTPTPTPTPTPTPTPSPTPTPALSPTPTPSPTLSPTPSPTPTPSPTPSPTPSPTPTPSPTPSPTPTPSPTPSPTPTPSPTPTPSPTPSPTPSPTPTPSPTPSPTPTPSPTPSPTPTPSPTPSPTPPPSPTPPPSPSPLGDPMYFPSSVGTTDQLRDYIRPLCNGWPRPRETYAVPWDCQRVMHCSYFSLPLHEVTCNDDSAYSFTADGCVPHYQSDCPFYPLNTL
What are the official names of this protein?
Uncharacterized 29.3 kDa protein.
Protein: DCUP_CHLPM
Sequence: MLKNDLFLRALKRQPCSRTPIWVMRQAGRYLPEYRAIREKTDFLTLCKTPELAAEVTIQPVELMGVDAAIIFSDILVVNEAMGMDVEIIETKGIKLSPPIRSQVDIDRLSVPDVHDKLGYVLDAIRLTKKELDNRVPLIGFSGAAWTLFTYAVEGGGSKNYAFAKKMMFRDPKMAHMLLSKISSVISDYVCAQVEAGADAIQIFDSWASALSEDDYREFALPYIKENVQALKTKYPDIPVIVFSKDCNTILEDIAATGCDAVGLGWGIDIAKARTILGDRVCLQGNMDPTVLYGTPEKIKAEAGKILKQFGQHTANSGHVFNLGHGILPDVDPANLKLLVEFVKEESAKYH
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AB3E_ARATH
Sequence: MTITRGDFKLRLNQGEFTDSQIIVMLGENGTGKTTFIKMLAGSKLDIDEEGSQVHEIPQFSVSYKNQHMSNRKFEITVRDLIHRKIPNAYAEHQFVSDVMKPLKIEELMDKSFNKLSGGEKQRVALALCLGKSADIYLIDEPSAFLDSEQRIIASKVIKRFILQMKKAAFARFHNGYVFGR
What are the official names of this protein?
ABC transporter E family member 3, ABC transporter ABCE.3, AtABCE3, MRP-related protein 4, Non-intrinsic ABC protein 15, AtNAP15, RNase L inhibitor-like protein 3, AthaRLI3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCE family.
Protein: NQOR_ECOK1
Sequence: MAKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: HHLA1_HUMAN
Sequence: MLGFLSRGPSMKLCMGLACVLSLWNTVSGIKGEAKKEKGMTFLPTTVSGLREEERKEKGVAFLATTELPARSIDLSALNLTELVNGMLSRALKDSKKFFSLLSVTSYSSFAFHKFSVAVYNISNLKTVDPAKFPTRYCYCLNNRTNDLSDFTALLVDIIGNSTSYLTEIFKSTSILSVNQSNESDCIFICVMTGKSGRNLSDFWEIEEKYPIINYTFTSGLSGVLGAATRGTARTSKPTTKSQKTLPSTSPGHWTQSTPWASALRSSPWTETAAPSETEETLNTGRPPELPARATATWFSASHTLPALATRRVARTQWLTADRQTWASISSVPWAQTISEKKPGGSLWETRSSPPTTAGTEEAMNTTSLLAPAAEIMATPGSPSQASPTLGAFTHGTQTPSPTKATAPRYPQTGDLSAEWPFTAGEEPVLVPRPHQVSRCPQPLFKVGAMAAAPLTLAIQRLNPCLMELCQFFQQCLCMSQRSPRTEDMRYCLEYYSWFLKNATYICQRVKRVSHSHTLKQKCLENICKSV
What are the official names of this protein?
HERV-H LTR-associating protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: UBIB_SALCH
Sequence: MTPGEVRRLYFIIRTFLSYGLDELIPRMRLTLPLRLWRYSLFWMPNRHKDKLLGERLRLALQELGPVWIKFGQMLSTRRDLFPPQIADQLALLQDKVAPFDGRLAKAQIEEAMGGLPVEAWFDDFDIQPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIQADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFENSPMLYIPEVYSDYCSQNMMVMERIYGIPVSDVAALEKNGTNMKLLAERGVKVFFTQVFRDSFFHADMHPGNIFVSHEHPENPQYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEDFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALTRALKEKAPFWVEKMPEIPELVYDSLRQGKYLQHSVDKIARELQVNHVRQSQSRYLLGIGATLLLSGSFLLVNRPEWGLMPGWLMVGGVVVWLVGWRKTR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARFK_DICDI
Sequence: MLSEFFNSLASFFSNIFSLFEGKKDTRILMIGLDGAGKSTLLFKLKLGDVVLTIPTIGFNVETIVYKNLSMTVWDVGGQHKIRALWKHYYHGTNAIIFVVDSTDRERMDEVKEEIDNLLIQDELKGIQILVLANKQDMNNAMNTAEIVNSLNLNSIKDRKWYVQPCSAIRSDGIYEGFDWVANSLNNK
What is the function of this protein?
GTP-binding protein that may be involved in protein trafficking.  May modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).
What are the official names of this protein?
ADP-ribosylation factor K.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: SSPA_HAEIN
Sequence: MSSASSKRSVMTLFSNKDDIYCHQVKIVLAEKGVLYENAEVDLQALPEDLMELNPYGTVPTLVDRDLVLFNSRIIMEYLDERFPHPPLMQVYPVSRAKDRLLMLRIEQDWYPTLAKAENGTEKEKTSALKQLKEELLGIAPIFQQMPYFMNEEFGLVDCYVAPLLWKLKHLGVEFTGTGSKAIKAYMERVFTRDSFLQSVGEAAPKNLMDDK
What is the function of this protein?
Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme.
What are the official names of this protein?
Stringent starvation protein A homolog.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. HSP26 family.
Protein: MINE_SHEWM
Sequence: MSLLDYFKSSKKPATAVTAKERLQIIVAHQRGERDAPDYFPQMKQEIIEVIKKYVHIDPEQVSVQLDKNDNKLSVLELNVTLPEKS
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RTC4_KLULA
Sequence: MVSSSNASSDQLSQESLVIISSSSHEGFSYGKRHPTVALNGSLNKKLRVRSGSLEELSDSEFDVSAKEEEKKSTELQDPKSIDLETQFSDVESDLDSLNERNKGADMLELTDDESVHELPGSSRDFFDENDVEEMSMELIKMYSIGLNAEGVSEFKKSSASLVLPKNTEKSTYLKSNAVRQKFMTKYDLPPVLFLDQLESRTREHISVCDAILTGKVSSLYYSMAKTVQKNSKRQVITNEELRDLNILKFTAGYFGSRRQAIVGMLILETYGEKLKRNKNPVISFWGPYDFSQYILAPEVLSYLCMDDFKLNNIEDAWDIMQTTIEFGTMVADLSPLEVYEIECEEESLRRLRLPQQYSSMSYRDDPRRKQDSNVG
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 4.
What is the protein family that this protein belongs to?
Belongs to the RTC4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RLMH_LISMO
Sequence: MNIQIVTVGKLKEKYLVQGIAEYLKRLSAYAKVTIVEVPDEKAPEVLSDAEMKQVKDKEGARILAKIPDDAYVIALAIDGKMKSSEEFAADLDKLATYGKSKVTFVIGGSLGLSEAVLKRSNERISFGRLTLPHQLMRLVLVEQVYRAFRIVRGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_SHEHH
Sequence: MNNVLFVALGGSIGAVLRYLISLLMLQVFGSGFPFGTLVVNILGSFLMGVIFALGQVSELSPEIKAFIGVGMLGALTTFSTFSNESLLLMQEGELVKAVLNVVVNVGVCIFVVYLGQQLVFSRF
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NALF1_BOVIN
Sequence: MTRGAWMCRQYDDGLKIWLAAPRENEKPFIDSERAQKWRLSLASLLFFTVLLSDHLWFCAEAKLTRARDKEQQQQQQQQQQRQQRQRQEQRQRQRQHEPSWPALLASMGEPSPAAQAHRLLSASPSPTLPPSLGGGGGGKGGRGTDSRGKPPLPGNSARPAWRLETCYPQGASSGQCFTVDSADAVCARNWSRGAAARGEQGQQTRGPPQPTPLWNLSDFYLSFCNSYTLWELFSGLSSPNTLNCSLDVVLKEGGEMTTCRQCVEAYQDYDHHAQEKYEEFESVLHKYLQSEEYSVKSCPEDCKIVYKAWLCSQYFEVAQLNCRKTIPCKQYCLEVQTRCPFILPDNDEVIYGGLSSFICTGLYETFLTNDEPECCDVRREAKPKSPSKGAGDRGGACPRTSLSASSAPRLGPSRLRLCVLVLMLLHTVLTASVAHNATALGVGGVHTLDERSASEE
What is the function of this protein?
Auxillary component of the NALCN sodium channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability.
What are the official names of this protein?
NALCN channel auxiliary factor 1, Transmembrane protein FAM155A.
What is the protein family that this protein belongs to?
Belongs to the NALF family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRMN6_AERS4
Sequence: MGRNSGFTFKQFHVEHDRCAMKVGTDGILLGAWAPVAETRRVLDIGTGSGLVALMLAQRSRSDCIIDAVDLDMNAATQARENVAASPWETRINIMEGAIQDYQATPYDLIVSNPPYFGAGQSLRDPARALARHTGSLDSRDLLAACDRLLTPVGQVALVLPTAMADEILCISADYDLHGVCYTAVINRAGKEANRVLLLLGRGLNRCEQGEIVIHSAGGAYSDRYIQLTHPFYLKM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_PARL1
Sequence: MKIDVTTLEAKKAGSVDLTDGVFALEPRGDILHRMVAWQLAKRQAGTHKTKGRSEIALTGKKFVKQKGSGGARHGDRKAPQFRGGGKAFGPVVRSHAFDMPKKVRALALKLALSAKAKSDNLVILDEAKLAEPRTKAAKDAFEKLGLKSVLIIDGAELDANFALAARNLPNVDVLPVQGINVYDILRREKLVLTKAAVESLEARFK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ISPDF_HELPJ
Sequence: MSLIRVNGEAFKLSLESLEEDPFETKETLETLETLIKQTSVVLLAAGESKRFSRAIKKQWLRSHHTPLWLSVYESFKEALDFKEVILVVSELDYVYIQRHYPKIKLVKGGASRQESVRNALKVIDSTYTITSDVARGLANMEALKSLFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREAIKLIQTPQLSHTKTLQSALNQGGFKDESSAILQAFPNSVSYIEGSKDLHKLTTSGDLKFFTPFFNPAKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELLEMGATIFSEIPKITPYKPAILENLSQLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQKL
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: FFSF_ASPFV
Sequence: MTQIKLLLLSLAITAQSITYDLPSQWDHQWLTQQPLGSDTTCTTSHLTAFQMSKTKDPIFFSTGGTDPFLSPKMLPLNSTAGEQWEFDGVSPDAKMAFVFGFYRDPNYAILGSGNLRVSVEMLWPNGTRFAQVDYPTDSVIEECEWGTRGVWRADEFSYSFEVSRDLQTARVAMHTPQVTGVVYLDSESKPRYPDGKIYPSETSTSEALPYFHFVEPIPVAKSQVDLMILGESYVWSDGVGGMERLWGAFSWFTCLQGMNVVRLHAGPYALSLLSFTSNIKKGNEYPSIALFENGEPVFSSQRTEDSDTADYFTFTKTYDGKVTGTLRDKVTGYELELVSPGEKKHWTFIIDHESLAFEYILGGGHGGSGFAGFVQGGRVGLEQFRGIALTEALTFPKKSPLFRSQYSETS
What is the function of this protein?
Diels-Alderase; part of the gene cluster that mediates the biosynthesis of the cytotoxic leucine-containing cytochalasans, including aspochalasin C, aspochalasin E, TMC-169, flavichalasine F, aspergillin PZ, aspochalasin M and flavichalasine G (PubMed:32913332).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS ffsA that utilizes 8 units of malonyl-CoA to iteratively assemble the octaketide chain before addition of L-leucine by the C-terminal NRPS modules (PubMed:32913332).  Because ffsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase fssC (Probable).  The methyltransferase (MT) domain of ffsA catalyzes the alpha-methylation at C10 and C14 using S-adenosyl-L-methionine as the methyl-donating cosubstrate (Probable).  Reduction by the hydrolyase ffsE, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ffsF then yield the required isoindolone-fused macrocycle (By similarity).  A number of oxidative steps catalyzed by the tailoring cytochrome P450 monooxygenase ffsD, the FAD-linked oxidoreductase ffsJ and the short-chain dehydrogenase/reductase ffsI, are further required to afford the final products (Probable).
What are the official names of this protein?
Diels-Alderase ffsF, Cytochalasans biosynthesis cluster protein ffsF.
What is the protein family that this protein belongs to?
Belongs to the Diels-Alderase family.
Protein: NADA_PROA2
Sequence: MTALQPYTIPSQDDRQSVLADKIKRLREERNAIILAHYYTVPEIQQVADVVGDSLALARAAETTDADVIVFAGVYFMGETAKILNPGKTVLMPDNSAGCPLADSCPADRFRSFREQYPDALVISYINSTAEIKAESDIICTSSNAVDIVSQIPSDKRIIFGPDRNLGSYVMQQLEREMILWQGFCYVHESYSWDVIETAVRQFPDAQLIAHPECRREVLDHADFVGSTGALLAYSQKSPADAFIVATEPGILYEMKKRSPEKSFIAAPKDIVSSQSVCSQMKQNTMENLCNCLETMAPQIVVDETLAAGALKSIRKMLEMSK
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD40L_MACNE
Sequence: MIETYNQPSPRSAATGLPVRMKIFMYLLTIFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLDCEEIKSQFEGFVKDIMLNKEEKKKENSFEMQKVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSTKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL
What is the function of this protein?
Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
What are the official names of this protein?
CD40 ligand, CD40-L, Tumor necrosis factor ligand superfamily member 5.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cell surface. SUBCELLULAR LOCATION: [CD40 ligand, soluble form]: Secreted. Note=Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
Protein: G6PI_ROSS1
Sequence: MTVLTHRPEWRALETHYHAICNVHLRQLFAEDPGRGERLTAEAAGLFFDYAKNRITDETLRLLIALAEACDLRARIDAMFRGERINATENRAVLHVALRAPRGAVILVDGANVVPEVHAVLDRMAAFAEQVRSGRWTGFTGKPIRNIVNIGIGGSDLGPVMAYEALRYYSDRNLTVRFVSNVDGSDFAEATRDLDPAETLFIVASKTFTTLETMTNARTARAWALAALGDEAAVARHFVAVSTNAAEVAKFGIDTANMFGFWDWVGGRYSMTSAIGLSTMIALGPERFHELLAGFHAMDEHFRTAPFDRNLPVIHGLLTIWYANFFGIETVAILPYDNYLKRFPAYLQQLTMESNGKSVTLSGAPVSYQTGMIYWGEPGTNGQHSFYQLLHQGTRLALCDFIGFAEPLNPLGNHHDLLMANMFAQAEALAFGKTTEETLAEGTPEWLAPHRTFAGNRPSNTLLAERLTPATLGALVALYEHSVFTQGAIWDINPFDQWGVELGKALAGRIVPELMSESAPHLAHDSSTNALIRRYRTLRGRVS
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.