PharMolix/UniProtQA huggingface dataset:
Protein: E2AK3_RAT
Sequence: MERATQPRPRALLLLFLLLGCAAGISAVARARSLLAPTSDTAFGLGAAAAPTSAARVPAVATAEVTVEDAEALPAASGEQESRATESDDDVELRPRGRSLVIISTLDGRIAALDAENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGDLFQWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKLRYICSALGCRRWDSDEMEEEEDILLLQRTQKTVRAVGPRSGSEKWNFSVGHFELRYIPDMETRAGFIESTFKLGGNKEDSKIISDVEEQDVDTVIKVSVADWKVMAFSKKGGRLEWEYQFCTPIASAWLVRDGKVIPISLFDDTSYTANEEVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRVSEKFPTRPKALESVNGESAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKYSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDSPHYSKNIRKKDPILLLHWWKEIFGTILLCIVATTFIVRRLFHPQPHRQRKESETQCQTESKYDSVSADNSDNSWNDIKHSGYVSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRQMDPFSTKEQIEVIAPSPERSRSFSVGISCGRTSSSESQFSPLEFSGTDCGDNSDSEDAAHNLQDSCLTDCDMEDGTVDGDDEGHSFELCPSEASPYTRSREGTSSSIVFEDSGCDNASSKEDPRMNRLHNGHHYVNKLTEFKHSSSRSSSEATLSTSPTRPTTLSLDFTRNTVDRLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSMEDREHRVCLHIFLQIAEAVQFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPQEHMMVQDMLSPSPMERPEATDIIENAVFENLEFPGKTVLRQRSRSLSSSGTKHSRQPSSTFSPLPGN
What is the function of this protein?
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions.  Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (By similarity).  EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (By similarity).  Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1).  Involved in control of mitochondrial morphology and function (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: FKBP5_MOUSE
Sequence: MTTDEGTSNNGENPAATMTEQGEDITTKKDRGVLKIVKRVGTSDEAPMFGDKVYVHYKGMLSDGKKFDSSHDRKKPFAFSLGQGQVIKAWDIGVSTMKKGEICHLLCKPEYAYGSAGHLQKIPSNATLFFEIELLDFKGEDLFEDSGVIRRIKRKGEGYSNPNEGATVKVHLEGCCGGRTFDCRDVVFVVGEGEDHDIPIGIDKALVKMQREEQCILYLGPRYGFGEAGKPKFGIDPNAELMYEVTLKSFEKAKESWEMDTKEKLTQAAIVKEKGTVYFKGGKYTQAVIQYRKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYNKAVECCDKALGLDSANEKGLYRRGEAQLLMNDFESAKGDFEKVLAVNPQNRAARLQISMCQRKAKEHNERDRRVYANMFKKFAERDAKEEASKAGSKKAVEGAAGKQHESQAMEEGKAKGHV
What is the function of this protein?
Immunophilin protein with PPIase and co-chaperone activities.  Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90).  Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.  Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1.  Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP5, PPIase FKBP5, 51 kDa FK506-binding protein, 51 kDa FKBP, FKBP-51, FK506-binding protein 5, FKBP-5, Rotamase.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RF1_METVS
Sequence: MSENSSTDMYLFKKSLKELKGKRGKGTELISVYVPAGRRLSDISQHLRQELSQSSNIKSKTTMKNVQSAIEVILQRLKLLKEPLEKGVIIFAGMIPRGGPGTEKMEVYVLEPPEPVKTFIYRCDSEFYTESLEDFIQDTEVYGVILVDRNEATIGTVKGKTITVLKKLTSGVPGKFKAGGQSARRLERLIDDAAHQFMVRIGEYSTESFMPILEEKKLRGLLIGGPGNTKNEFAEKDFLHHELKKKIIDTFDLCYTEEFGIRELLEKASDLLRDLDLMKEKNLIQKFFKELIKDDGGLSAYGESQVMRYLEMGAIDTLIVTEDIELTRVTIKCNNCNFKQEINVKTRDLYKFEDEVKTKICKQCSGSMYIEEEKDIIEYLSELCNIHNSDIVVVSTDTEEGSQISKAFKGMAAILRYKI
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
What are the official names of this protein?
Peptide chain release factor subunit 1, Translation termination factor aRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR11_POPAL
Sequence: MAKLLPRIGSRKNGRISSRKNARKIPKGVIHVQASFNNTIVTVTDVRGRVISWSSAGACGFRGTRRGTPFAAQTAAGNAIRTVVDQGMQRAEVMIKGPGLGRDAALRAIRRSGILLSFVRDVTPMPHNGCRPPKKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PARL_PONAB
Sequence: MAWRGWAQRGWGCGQAWAASVGGRSCEELTAALTPPRLLGRRFNFFIQQKCGFRKAPRKVEPRRSDTGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK
What is the function of this protein?
Required for the control of apoptosis during postnatal growth.  Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity).  Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP).  Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity).  Required for processing of CLPB into a form with higher protein disaggregase activity by removing an auto-inhibitory N-terminal peptide.
What are the official names of this protein?
Presenilins-associated rhomboid-like protein, mitochondrial, Mitochondrial intramembrane-cleaving protease PARL.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [P-beta]: Nucleus. Note=Translocated into the nucleus by an unknown mechanism.
Protein: MUTS_ACIAC
Sequence: MDKGINLQNDKEPSPMAEGNPADFSAHTPMMQQYLALKAGYPDTLVFYRMGDFYELFWADAEKAARLLDITLTQRGQSAGQPVVMAGVPFHALENYLGRLIRMGESVAICEQVGEVGAAKGPVERKVVRVVTPGTLTDSELLPDKAESMLLAVHQAPRARCGLAWLSVTQGVVHLAECTHDEVGTWIARIGPSEVIYSAGVTERFEQQLQALRQGGVLSCPLSLRPDWQFDGALGARKLLEQLGAASLNAWDAQDLAHAHAASAALLSYAEHTQGRALTHIHAVRVQKNDELIALPPATRRNLELTRTLRGEDAPTLFSLLDTCMTGMGSRLLKTWLLEPRRDRTEARARLAATAELRGDHGGTGSWQALRAALRGVSDVERITARIALRQVRPRELVALCKTLHKAEQIAAEHRWQDPLLAGISGDLHAPPACGALLAGAILEEPSALVRDGGVIADGFDAELDELRGIQNHCDDFLLALETREKARTLIPNLRVQFNKVHGFYIEVTSSYLDRIPDDYRRRQTLKNAERFITPELKAFEDKALSAQERALAREKWLYEQVLDQLQQHVPALTRAAQAIAALDALCALAERSLTLGWCAPQFAAEPCIEIEGGRHPVVEARLAETSAGAFIPNHTRLNANTRMQIITGPNMGGKSTYMRQVALIVLLASMGSHVPAAHCRLGPIDAIHTRIGAADDLANAQSTFMMEMTEAAQILHAATPHSLVLMDEIGRGTSTFDGLALASGIATHLHDRTRAFTLFATHYFELTELAARHAHAVNVHVGATESGSDIVFLHEIQPGPASRSYGIHVARLAGVPAPVLNHARHALSALEERANEGETQVDLFAPPPESEAPGISPVEAALQGIHPDSLSPREALDALYQLKRLAQPG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: FCTA_SHIB3
Sequence: MSTPLQGIKVLDFTGVQSGPSCTQMLAWFGADVIKIERPGVGDVTRHQLRDIPDIDALYFTMLNSNKRSIELNTKTAEGKEVMEKLIREADILVENFHPGAIDHMGFTWEHIQEINPRLIFGSIKGFDECSPYVNVKAYENVAQAAGGAASTTGFWDGPPLVSAAALGDSNTGMHLLIGLLAALLHREKTGRGQRVTMSMQDAVLNLCRVKLRDQQRLDKLGYLEEYPQYPNGTFGDAVPRGGNAGGGGQPGWILKCKGWETDPNAYIYFTIQEQNWENTCKAIGKPEWITDPAYSTAHARQPHIFDIFAEIEKYTVTIDKHEAVAYLTQFDIPCAPVLSMKEISLDPSLRQSGSVVEVEQPLRGKYLTVGCPMKFSAFTPDIKAAPLLGEHTAVVLQELGYSDDEIAAMKQNHAI
What is the function of this protein?
Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR).  Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate (By similarity).
What are the official names of this protein?
Formyl-CoA:oxalate CoA-transferase, FCOCT, Formyl-coenzyme A transferase, Formyl-CoA transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. Frc subfamily.
Protein: SMAD9_HUMAN
Sequence: MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
What is the function of this protein?
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase.  SMAD9 is a receptor-regulated SMAD (R-SMAD).
What are the official names of this protein?
Mothers against decapentaplegic homolog 9, MAD homolog 9, Mothers against DPP homolog 9, Madh6, SMAD family member 9, SMAD 9, Smad9.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).
Protein: SNIT1_HUMAN
Sequence: MSHHPHSLRNSCLIRMDLLYWQFTIYTITFCFSHLSGRLTLSAQHISHRPCLLSYSLLFWKVHHLFLEGFPCSPRLDEMSFHQFPQHPVHVSVVHLPIVYKGSMTQVSPH
What are the official names of this protein?
Uncharacterized protein encoded by SND1-IT1, Brain and nasopharyngeal carcinoma susceptibility protein NSG-x, Nasopharyngeal carcinoma-associated gene 8 protein, SND1 intronic transcript 1.
Protein: MUTL_BACLD
Sequence: MAKIVQLPDDLSNKIAAGEVVERPASVVKELVENAIDANSSVIEIDVEEAGLASIKVLDDGEGMDAEDCRTAFLRHATSKIKDENDLFRVRTLGFRGEALPSIASVSHLSIKTSTGEGAGTHLTLQGGRIISEQKAPSRRGTEITVTNLFFNTPARLKYMKTIHTELGNITDVVNRIALAHPEVSIRLRHQGKTLLQTNGNGDVRHVLAAIYGTAVAKKMLPLEARSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAIHEGYHTLLPIGRHPITFIEINMDPLLVDVNVHPSKLEVRLSKETELHELIRDAIKDVFKQQQLIPSVQVPKKTAPLINKPEQQKLDFDQVREPAPLSDSDVEREYKPEPSFSAMKLSSLVKDPPPSAPVEREENVMQDTEPEWPGAEEYTPEAAPAVQAEPEQAGENVQDEETPKERVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIKYEYFREKVGEVESEVQDLLVPLTFHYSKNEALTIDQHLDDLAKVGVFLESFGAGSYIVRCHPTWFPKGEETTIIEDIIQQVLDDRTIDIKKLREEAAIMMSCKGSIKANHHLRDDEITALLDELRRTSDPFTCPHGRPIIIHYSTYEMEKMFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: YBEY_HERAR
Sequence: MQQNKLSLSVQYADTRVQDILTRPLLRKWVKAALLAPAQITLRFVDAAEGQILNRNYRGKDYATNVLTFTYNDDDGSDIADDAVTQADIILCTDVLQREAAEQNKTLIFHAAHLVIHGVLHAQGYDHESDEEAEEMEALEIEFLAALGFPNPYIEA
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_XANOM
Sequence: MTQPTARSIPLQVVSGDTAAPAPLQTGVKQIGGDKIHRSPVQFVDAPVLRKPSWIRVRIPSGNAVQNLKAKLRENRLVTVCEEASCPNIHECFSHGTATFMILGEVCTRRCSFCDVAHGRPKPPDANEPASLAITVADMGLKYVVVTSVDRDDLRDGGAQHFVDCISAIRTSSPNTRIEILTPDFRGKGRMDRALDILALSPPDVFNHNIETVPDLYPNVRPGADYQWSLTLLQRFKAQHPSIATKSGIMLGLGETMEQVQATLRDLRAHDVDMITIGQYLQPTPHHHPVMRYWTPEEYKALEEYGNALGFSHVASGPMVRSSYHADRQAAGAGVAA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDH_DESVH
Sequence: MNRIAVIGVGNVGMAFAYAAAIKRLANDIVLIDANAARAEGESMDLADAMALVGPVQIRSGGYEQCEGARIVVVTAGAKQMPGQSRLDLVRVNAGITRDILTAVMQYADDPLYIMATNPVDVLTHVARTVTGVAPGRVIGSGTVLDSARFRGHVAEILGVDVRGVHAHIVGEHGDSEVALWSRANVSGIPVAEMCARRGIAYDAAFREKALGHVRHAAYEIIGRKGATGYGIGMSLCRIVEAILHDEHSVLTVSCPVAGHYGLGDVSLSLPCVIGSDGIEEVLDAPIAEDEQAALAASARVLGEHLAAL
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATY_SHIB3
Sequence: MYVVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAANLHAPVIIAGTPGTFTHAGTENLLALVSAMAKQYHHPLAIHLDHHTKFDDIAQKVRSGVRSVMIDASHLPFAQNISRVKEVVDFCHRFDVSVEAELGQLGGQEDDVQVNEADAFYTNPAQAREFAEATGIDSLAVAIGTAHGMYASAPALDFSRLENIRQWVNLPLVLHGASGLSTKDIQQTIKLGICKINVATELKNAFSQALKNYLTEHPEATDPRDYLQSAKSAMRDVVSKVIADCGCEGRA
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires GatZ subunit for full activity and stability.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.
Protein: RNC1_SCHPO
Sequence: MAYNHFSIPKNIEEKENSFFDVTFQDEPDETTSTATGIAKVSIPTPKPSTPLSTLTNGSTIQQSMTNQPEPTSQVPPISAKPPMDDATYATQQLTLRALLSTREAGIIIGKAGKNVAELRSTTNVKAGVTKAVPNVHDRVLTISGPLENVVRAYRFIIDIFAKNSTNPDGTPSDANTPRKLRLLIAHSLMGSIIGRNGLRIKLIQDKCSCRMIASKDMLPQSTERTVEIHGTVDNLHAAIWEIGKCLIDDWERGAGTVFYNPVSRLTQPLPSLASTASPQQVSPPAAPSTTSGEAIPENFVSYGAQVFPATQMPFLQQPKVTQNISIPADMVGCIIGRGGSKISEIRRTSGSKISIAKEPHDETGERMFTITGTHEENEKALFLLYQQLEMEKDRRSH
What is the function of this protein?
Binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling.  Overexpression suppresses the Cl(-) sensitivity of calcineurin deletion.
What are the official names of this protein?
RNA-binding protein rnc1, RNA-binding protein that suppresses calcineurin deletion 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1458_STAAR
Sequence: MVKTVYVTGYKSFELNIFKDDAPEVHYLKQFIKHKIEQLLDEGLEWVLIQGQMGIELWTAEVVIELQRTYDSLKFAVITPFQGHTEKWNEHNQSKYANIIKHADYVDSIFHTSYQGPFQFKQADQFMLEHSDQTLLIYDEEQEASPKFFKQMLVDFMDKTNYTCDIVTFDELTAFINDLQWSEDQSF
What are the official names of this protein?
UPF0398 protein SAR1458.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: MURG_CORGB
Sequence: MRVVVAGGGTAGHIEPALAVAEALRDKHGATVSALGTARGLETTLVPDRGFELHLIEPVPVPRKPNMDLLKLPFRVAKALGQARKALKDTDAQAVIGFGGYVSAPAYMAAKSLGLPFFVHEANARAGMANKLGVKLGGVGLNAVAGSGMEGDVVGIPIRAVLSGARDESAADRARDTWGLDKDRQTIFVTGGSQGSVSINKAVEQAVDQLVEAGFQVLHAVGKKNELPAAKPGYHPVPFIDDMQAAYTVADLIVCRSGAMTVAEVTAAGVPAIYVPLPHGNGEQALNAQAVIKAGAARQIDDADFTAQTLIDATLDILLHPSTHQSMSDAAKTSTAGNASTVIADMIAATIKSQHN
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ASAP1_BOVIN
Sequence: MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGESSLEELTKAIIEDVQRLPGNDVCCDCGSAEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSSSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTALHYCSMYSKPECLKLLLRSKPTVDVVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEMDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLSLPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPIAEAPPLPPRNATKGPPGPPSTLPLSTQTSSGSSTLSKKRSPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDVGPSSSSKTTNKFEGLSQQSSTGSAKTALGPRVLPKLPQKVALRKTETSHHLSLDKANVPPEIFQKSSQLTELPQKPPPGDLPPKPTELAPKPPIGDLPPKPGELPPKPQLGDLPPKPQLADLPPKPQVKDLPPKPQLGELLAKPQTGDASPKAQPPLELTPKSHPADLSPNVPKQASEDTNDLTPTLPETPVPLPRKINTGKSKVRRVKTIYDCQADNDDELTFMEGEVIVVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
What is the function of this protein?
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6.  May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2.  Plays a role in ciliogenesis (By similarity).  May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types.
What are the official names of this protein?
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1, 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein, ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, Development and differentiation-enhancing factor 1, DEF-1, Differentiation-enhancing factor 1, PIP2-dependent ARF1 GAP.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=Predominantly cytoplasmic. Partially membrane-associated.
Protein: UVRB_MYCBO
Sequence: MAFATEHPVVAHSEYRAVEEIVRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRSVELKVGEEVPRDGLLRLLVDVQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVDSLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDISRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPYELSQTGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQTIGRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAYNEANGIDPQPLRKKIADILDQVYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVSAGVFEGRDTSAMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKRELRGMDAAGLK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AATP6_ARATH
Sequence: MLEVGTIWGFTSTTMASIMFLWPMYKQFVPYQLREYLENTIQKYLDKLFRRDSNFVYIRFPEYTGEGLSKSRAYDEIGNYLSSISTARAKRLKAKESENSKSLVLCLDDDEAVVVVFQGVNVVWSSTVVDKEDKHNSKEGRYLTLTFENHHRDIITNTYIDHVLREGKEIALKNRERKLYTNNDSSSYSSWWEGLWSNVPFNHHASFETLGMDLDKKEEIKKDLIKFTKGKDYYRKVAKPWKRGYLLFGPPGTGKSTMISAIANFLEYDVYDLELTTVKDNAELKKLMLDTKGKSIVVIEDIDCSLELTEHRKKKKEEDEDKEEKKEAENLKRVSGNNESNVTLSGLLNAIDGLWSACSDEKIIIFTTNFVDNLDPALIRRGRMDYHIEMSYCRFEAFKVLAKNYLENESHDLYGEIGRLLEEVDVSPADVAENLMPKSDEDDADICFRRLVKSLEEEKKKKIEKEARKNKKKAEDNVKQEKQNKVKGMVTK
What are the official names of this protein?
AAA-ATPase At3g28520.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. BCS1 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YUBD_ECOLI
Sequence: MSRFIQGDCVRVMATFPGNAVDFILTDPPYLVGFRDRQGRTIAGDKTDEWLQPACNEMYRVLKKDALMVSFYGWNRVDRFMAAWKNAGFSVVGHLVFTKTYTSKAAYVGYRHECAYILAKGRPALPQKPLPDVLGWKYSGNRHHPTEKPVTSLQPLIESFTHPNAIVLDPFAGSGSTCVAALQSGRRYIGIELLEQYHRAGQQRLAAVQRAMQQGAANDDWFMPEAA
What is the function of this protein?
A putative beta subtype methylase whose recognition site is unknown.
What are the official names of this protein?
Putative methylase YubD, Type II methyltransferase M.EcoCR63FORFAP, M.EcoCR63FORFAP.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: TXVE_SISCA
Sequence: MAAYLLAVAILFCIQGWPSGTVQGQAMPFMEVFERSVCQTREMLVSILDEHPDEVAHLFRPSCVTVLRCGGCCTDESLMCTATGKRSVGREIMRVDPRKETSKIEVMQFTEHTECECRPRSGRVNSGKRKRNPEEGGAESQVPLGLTSF
What is the function of this protein?
Snake venom VEGFs that may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension.  This protein induces an increase in capillary permeability after intradermal injection, as well as a drastic hypotensive effect after intravenous injection (By similarity).  The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase.  Also induces angiogenesis in vitro (By similarity).  Like other crotalid VEGFs, this protein interacts with VEGF receptor-1 (FLT1) with a high affinity, whereas it binds to VEGF receptor-2 (KDR) with a low affinity (By similarity).
What are the official names of this protein?
Snake venom vascular endothelial growth factor toxin 2, svVEGF, VEGF-F.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family. Snake venom VEGF subfamily.
What are the subcellular locations of this protein?
Secreted.