PharMolix/UniProtQA huggingface dataset:
Protein: IOLC_LISMH
Sequence: MNLNKHSERKFDLITVGRACIDLNAVEYNRPMEETMTFSKYVGGSPANIAIGTAKLGLKVGFIGKISADQHGRFIEKYMRDLSINTDGMVKDTEGRKVGLAFTEIKSPDECSILMYRENVADLYLTPEEISEDYIKEARVLLISGTALAQSPSREAVLKAVSLARKNDVAIAFELDYRPYTWTNTEETAVYYSLVAEQADVIIGTRDEFDMMENQVGGKNEATKAHLFQHQAEIVVIKHGVEGSFAYTKAGETFQAKAYKTKVLKTFGAGDSYASAFLYGLFSGESIETALKYGSAAASIVVSKHSSSDAMPTADEIKALIAQAE
What is the function of this protein?
Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).
What are the official names of this protein?
5-dehydro-2-deoxygluconokinase, 2-deoxy-5-keto-D-gluconate kinase, DKG kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: RL11_STRAT
Sequence: MPPKKKKVTGLIKLQIQAGAANPAPPVGPALGQHGVNIMEFCRAYNAATESQRGWVIPVEITVYEDRSFTFITKTPPAAKMILKAAGIEKGSGEPHKTKVAKITEAQVREIATTKLPDLNANDLDAAAKIIAGTARSMGVTVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: NOP16_LODEL
Sequence: MVSVRKRKMARSSVKKNTRRRKDKQRDINIHSNPIIAKNWDKSLTLKQNYKRLGLRSKLGNIAGGVEQKVETLTEIRNKRRAKLELLLLLQSVSIEEIEETEDPSRIPIGEARIIRDPETNEVLRVIYGTMKVDGDDNDNVSDAAEETEEREGQGANSVIKELEEYAAKHAKVRKERHMSDRESEWAKALYEKYGDDYERMKWDKKLNVYQQSAGDLKRRITKWKKANNIQ
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Nucleolar protein 16.
What is the protein family that this protein belongs to?
Belongs to the NOP16 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: IGBP1_RAT
Sequence: MAASEEELLLPRLPELFETSKKLLEELEVATEPTGSRTIQDKVSKGLELLEKAAGMLSQLDLFSRNEDLEEIASIDLKYLMVPALQGALTMKQVNPSKRLDHLQRAREHFIHFLTQCHCYHVAEFQLPQTKNNSAENNTARSSMAYPNLVAMASQRQAKIERYKQKKEVEHRLSALKSAVESGQADDERVREYYLLHLRRWIGISLEEIESIDQEIKILKDKDSPREESACQSSLPEKPPMKPFILTRNKAQAKVFGTGYPSLATMTVSDWYEQHQKYGALPDRGIAKPPSADFQRAAQQQEDQEQKDEENEEKALHRMREWDDWKDTHPRGYGNRQNMG
What is the function of this protein?
Associated to surface IgM-receptor; may be involved in signal transduction.  Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits (By similarity).
What are the official names of this protein?
Immunoglobulin-binding protein 1, Alpha4 phosphoprotein, CD79a-binding protein 1, Protein phosphatase 2/4/6 regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the IGBP1/TAP42 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_BACCZ
Sequence: MQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKLQEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQVLIDHFASCRVRLVDFKLEFGVTDEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTDAYEEILKRLGGISHV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: MRAY_DICNV
Sequence: MLYALATGLSAIFTPLNALTYLTSRIILGALTALLLSIFCGGKMIRYLQKMQMGQFVRDDGPKTHLKKAGTPTMGGALIIFSITVSMLCWADLRSVYTWLALFVLLGFGAVGWTDDYLKLVKKNTKGLAAKQKYAYLSLVALLTALWLYFLADTPIETTLIMPFFKHFEWQMGILFIPFVYLVLTGASNAVNLTDGLDGLAIMPVVLVSGGLCIFAYLSGSANFALYLHIPAIAGAGEMAIFCAAIAGAGLGFLWYNAHPALVFMGDVGALSLGAALATVAVVVRQELAFAVMGGVFVAEALSVMIQVGSYKCRGKRVFRMAPLHHHFELGGWPESRVTIRFWIITVVLVLVGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL23_UREPA
Sequence: MELTRVILHPYTTEKTYSIRNKSEHETLTFIVDKNANKYQIREAFIAIFGLKPLKIRTTNRRPAKIRTSTARPGYTKAKKIAYVVMPVGVKVAVSKEEVEAANAK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: MIP_ARATH
Sequence: MWKLTRRLQPHINSTRWLVRNFRNGGAGDATGLYGFDHLKTAKGFQRFVADAIERSGELVSYISGMPSSPEIIKAMDEISDTVCCVVDSAELCRQTHPDREFVEEANKAAIEMNDYLHHLNTNHTLYAAVKKAEQDSNLLTKEASRTAHHLRMDFERGGIHLDPEKLDKVNNLTTNIFQLCREFSENIADDPGHVDIFPGSRIPRHLHHLLNPTYRSTSGGSRGSTRSAHKSKQKGFRINTDPRTVSSILQWTSDEEVRKMVYIQGNSVPHANHGVLEKLIAARHELSQMMGCNSYADIMVEPNLAKSPKVVTSFLQELSKTVKPKADEEFIAIRDFKREKCGNPSAELEPWDETYYTSMMKSSINDVDTAVVASYFPLPQCIEGLKVLVESLFGATFHTIPLAPGESWHPNVVKLSLHHPDEGDLGYLYLDLYSRKGKYPGCASFAIRGGRKISETEYQLPVIALVCNFSRACDSSIVKLNHSEVEVLFHEFGHALHSLLSRTDYQHFSGTRVALDLAEMPSNLFEYYAWDYRLLKRFARHYSTGETIPEKLVNSLQGARNMFAATEMQRQVFYALIDQMLFGEQPETARDVSHLVAELKRQHTSWNHVEGTHWYIRFSHLLNYGAGYYSYLYAKCFASTIWQSICEEDPLSLNTGTLLREKFFKHGGAKDPAELLTDLAGKEIISVHGEGIVPATTYLLNELRL
What is the function of this protein?
Aminopeptidase which cleaves preproteins, imported into the mitochondrion, to their mature size.  Could cleave both preproteins and preprotein intermediates already cleaved by the mitochondrial processing peptidase (MPP).
What are the official names of this protein?
Mitochondrial intermediate peptidase, mitochondrial, AtOCT1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: WHIA_LACP3
Sequence: MASFASLVKKELTQLEVHPEHAKAELSALIRMNGSLTLMAHRFVLNIQTENPAIARRIYSLIRQVYHHEANLVVHRKMKLKKNYQYIVRLTEGVNDILSDLSILDPDTMAISTTVPASVLKEPQRMRSYLRGAFLASGSVNNPETSRYHLEIYSLYDNHNAGILKMMNHFNLNARTVERRSGYIVYLKEAEKIADFLQVIGATNAMLKFEDVRIMRDMRNSVNRLVNCENANMNKTIDAAQKQIENINYLKNHVGLDNLPAKLREIAVLRLAHPDVSLQELGAMMPSGQISKSGVNHRLRKLNQIAEGYQQPEDA
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: RRF_HYDCU
Sequence: MIDEIFDDANDRMTKSVENLESNFAKIRTGRAHPSILDAVKVDYYGSEVPVSQVANVNVEDARTLTVQPWEQSMVSVVEKAIMTSDIGVNPVTTGNVMRIPMPPLTEERRKEFIKLAKSEAEQTKVAIRNIRRDANADFKNLNKDKEITDDELRQAEEQIQKATDEHVSQVDQMLAKKEESLMEI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_RENSM
Sequence: MPKMKTHSGAKKRFKLTGSGKLKRQQANRRHYLEHKPSTLTRRLAADKTVSPADAKNIKKMLGI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RPPH_SALG2
Sequence: MIDDDGYRPNVGIVICNRQGQVMWARRFGQHSWQFPQGGINPGESAEQAMYRELFEEVGLSRKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLMSADAEINMQTSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFASVVMALQDNPPKLQSAPAYRRKRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: ILVD_VIBC3
Sequence: MPKYRSATTTHGRNMAGARALWRATGVKEEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAIFVSGGPMEAGKTKLSDQIIKLDLVDAMMQGADPKVSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLTAGQRIVELTKRYYEQDDASVLPRNIANKAAFENAIALDIAMGGSTNTVLHLLAAAQEGEVEFDMTDIDRMSRQVPHLCKVAPSTQKYHMEDVHRAGGVMGILGELQRAGLLKDQTRTVLGISLQEQLAQYDVKQTQDPAVHTMFRAGPAGIRTTQAFSQDCRWDTLDDDRQEGCIRDKAHAFSQDGGLAVLKGNLAIDGCIVKTAGVDESILKFRGPAVVYESQEDAVNGILGGQVKAGDVVVIRYEGPKGGPGMQEMLYPTTYLKSMGLGKQCALLTDGRFSGGTSGLSIGHASPEAANGGTIGLVRSGDSIAIDIPNRSITLEVSESELAARRAEQDKLGWKPVDRQRTVSLALKAYASMATSADKGAVRDKSKLEG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: HSP1_CHRPI
Sequence: MARYRRNRSRSRSRRRRRRRGGRGGRRGRRRRRHGQRRRGRRGRERTRRRRRRRRRSSS
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1-type, Protamine I-1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL20_ECOSE
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: BIOB_SHESA
Sequence: MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKDKDMPYLKQMVQEVKALGMETCMTLGMLSAEQANELADAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLSHVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPKSRVRLSAGRENMTDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAATIDDEQAVLAKAAAHQDKASAPFYDAAAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: LLY_LEGPH
Sequence: MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEAHASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSPEPVVGNGLTAIDHLTHNVYRGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDIYKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFGPVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKELS
What is the function of this protein?
Catalyzes the transformation of p-hydroxyphenylpyruvate into HGA.  Has hemolytic and brown pigment production activity.
What are the official names of this protein?
4-hydroxyphenylpyruvate dioxygenase, 4HPPD, HPD, HPPDase, Legiolysin.
What is the protein family that this protein belongs to?
Belongs to the 4HPPD family.
Protein: METK_VIBC1
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVMVGGEVTTSAWVDIEEITRETVREIGYVHSDMGFDANSCAVLNTIGKQSPDINQGVDKADPKEQGAGDQGIMFGYATNETEILMPAPITYSHRLVQKQAEVRKSGKLDFLRPDAKSQVTFQYDQGKIVGIDAVVLSTQHCDSVTTPDLREAVMEEIIKPVLPSEWITKDTNFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGAARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGMADRCEIQLSYAIGVADPTSIMVETFGTEKVSHDIIIEAVRQFFDLRPYGLQEILNLLQPIYKQTAAYGHFGREEFPWEATDKAELLRDFAGIK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_VZVO
Sequence: MGDLSCWTKVPGFTLTGELQYLKQVDDILRYGVRKRDRTGIGTLSLFGMQARYNLRNEFPLLTTKRVFWRAVVEELLWFIRGSTDSKELAAKDIHIWDIYGSSKFLNRNGFHKRHTGDLGPIYGFQWRHFGAEYKDCQSNYLQQGIDQLQTVIDTIKTNPESRRMIISSWNPKDIPLMVLPPCHTLCQFYVANGELSCQVYQRSGDMGLGVPFNIAGYALLTYIVAHVTGLKTGDLIHTMGDAHIYLNHIDALKVQLARSPKPFPCLKIIRNVTDINDFKWDDFQLDGYNPHPPLKMEMAL
What is the function of this protein?
Catalyzes the reductive methylation of deoxyuridylate to thymidylate.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family.
Protein: RSXD_SALPB
Sequence: MVFRIASSPYTHNQRQTSRIMLLVLIAALPGIAAQTWFFGWGTLFQIVLAAITALVAEAIVLRLRKQSVASHLQDYSALLTGLLLAVSIPPLAPWWMVVLGTGFAIIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPYEIAATTPDMLDTLRMIFSGHTASGGDMTLLRIGIDGISQATPLDTFKTSLRAGHSVEQIMQYPIYSGALAGVGWQWVNLAWLVGGVFLLWQKAIRWHIPVSFLLTLALCAALGWLFSPATLASPQLHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGVLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHRKG
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rsx electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUOA_CHLCH
Sequence: MDQTLTQFGSVFVFLLLGVIFVVGGYLTSRLLRPSRPNPQKNSTYECGEEAIGSAWVKFNIRFYVVALIFIIFDVEVVFLYPWATVFKPLGTFALIEVLVFAGILILGLAYAWVKGDLDWVRPTPNIPKMPPMPELPVAKGASQKD
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GMT_PHANO
Sequence: MSDDKKSDDYRVDMPSSRTSRAPSPIMRPALKSAPSLTENPMAAVLAYCASSILMTVTNKYVLSGVDFNLNFFLLCVQSVVCVTAISICKAAGLITYRDFNTDEAKKWFPISLLLIGMIYTGTWALKYLSIPVYTIFKNLTIILIAYGEVLWFGGSVTPMTLFSFGLMVLSSIIAAWADIQHALNSFGQQSEAANEALSTMHAGYLWMAFNCVCSATYLLSMRKRIKLTNFKDYDTMYYNNLLTIPILLVASILVEDWSSANIQKNFPPEQRNTVIMVMVISGMSTVFISYTSAWAVRVTSSTTYSMVGALNKLPIAISGLVFFDAPVTFGSVSAIFVGFVSGIVYAVAKVRQNSKPKTVLPTTNIPLSASSRSMQDSLKA
What is the function of this protein?
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
What are the official names of this protein?
GDP-mannose transporter, GMT.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: FRIZ_DROME
Sequence: MWRQILFILPTLIQGVQRYDQSPLDASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARVCEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQAYV
What is the function of this protein?
Receptor for Wnt proteins.  Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
What are the official names of this protein?
Frizzled, Frizzled-1, dFz1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YSH1_DEBHA
Sequence: MTVDSQPADGTDDFKFFGLGGCNEVGRSCHIIEYKNKVIMLDAGVHPGLQGLSSLPFYDEYDLSKVDILLVSHFHLDHAASLPYVMQHTNFNGRVFMTHATKAIYRWLLSDFVKVTSIGGGSDARLNNSDPNANTGSSNLYTDDDLMRSFDRIETIDYHSTIELDGIRFTAYHAGHVLGACMYFIEIGGLKVLFTGDYSSEEDRHLQVAEVPPIKPDILITESTFGTATHEPRLEKETRMTNIIHSTLLKGGRILMPVFALGRAQELLLILEEYWSLNDDLQNINIYYASSLARKCMAVYQTYTNIMNDSIRLTTSATNSSKKQNPFQFKFIKSIKNLDKFQDFGPCVVVASPGMLQNGVSRELLERWAPDPKNAVIMTGYSVEGTMAKDLLTEPHTIQSAMNSDMTIPRRLSIEEISFAAHVDFQQNASFIEKVNPSKIILVHGESNPMGRLKSALLSKYASRKGTEQEVKVFNPRNCDEVTIGIKGLKVAKVLGTLAEEQLSYLKKEISTQIKKDNVKIEELSDDNMDKETMPESDEKADKESEDTKNDIDKNNDENANEKNIISTGKALSGVLVSKDFDLNLLQLQDLHEFTQLSTSIVKSKINLKINADISLMKWHLEQMFGFISILADDEETWECVIMDMIDISVEKNNSQSAGGLLINVEWVNDNLMADSLADSVIAILYSIDSSPASVKLTSKSCSHSHNKVKEEVDDDAMIESTPPPEKNAHANSEISSRIHRITSLLKAQFGDSLKTAAGEEGKKATIVIGKNEAKIDYLNLTVDCNSRVLRDRIENIIKRGCGLAAPLSQYEKTT
What is the function of this protein?
Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
What are the official names of this protein?
Endoribonuclease YSH1, mRNA 3'-end-processing protein YSH1.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HRCA_SYMTH
Sequence: MIDDRKNKVLQAIIEDYVATAEPVGSRTIARKYNLGVSPATIRNEMSDLEELGYLEQPHTSAGRIPSNLGYRYYVDCLMPERPINPAEQELIRSTFQRKIRELDTLVRETARLLSETTHLTAVISGPQFEKAVFKEIRIVPLGNDRALLIYITDSGLVENQVVEVPLQVTMLELQQVAELLSEHLRGRRVETLSRTALQSLHRELSRYGTLLEQALHFLEQKLEPGDRHRLYFGGTSHMLDQPEFRDVQKLRGVLSFLEQEEAVAAVLGLDRLTEGVEIQIGEEIRLRELADCSVVTATYRVGDRIIGKMGVIGPRRMEYPKVVSILNAIASHLSEMNRLF
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: Y866_RICPR
Sequence: MVNFNQFLKQAQSMQKKMQEAQEQMANTRYTGKAGGMLVEIIITGKGEVEKISIDESLLKTEEKEMLEDLIKVAFNDAKQKCDEDSQNSLSGALNGMSLPPGFKIPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein RP866.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: Y584_CHLTR
Sequence: MTTKPKTLEIDNNTFLLLEGNLKRIFATPIGYTTFREFQNVVFNCAQGQQELANFLFEMLINGKLLQELPAGQKQSAQSLIVQFMMPIRVAKDIHERGEFINFITSDMLAQQERCVFLNRLSRVDGQEFLLMTDVQNTCHLIRHLLSRLLEAQKNPIGEKNLQEIQEDLDSLRAHFEELTKSV
What are the official names of this protein?
Protein CT_584.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0803/CT_584/TC_0873 family.
Protein: MED31_NEUCR
Sequence: MASDPMSVNSSAREPPAPPGSGADEPKYGGYTRFELELEFVQALGNPLYLNHLASRKLLSNPAFIAYLDYLQYWSRPPYLKYITYPGPTLKNLELLQQEKFRQDIISPDLVERLRLEGMKAGIDWHRESFPSTA
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 31, Mediator complex subunit 31.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 31 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MRP_BOVIN
Sequence: MGSQSSKAPRGDVTAEEAAGASPAKVNGQENGHVKSNGDLSPKGEGESPPVNGTEEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEISACGEEGTAQEGKAAATPESQEPQAKGAEASAAAKGGDTEEAGPQAAEPSTPSGPESDPAPASEQNE
What is the function of this protein?
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation.  When unphosphorylated, induces cell migration.  When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration.  May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
What are the official names of this protein?
MARCKS-related protein, MARCKS-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the MARCKS family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin. Colocalizes with F-actin at the leading edge of migrating cells.