PharMolix/UniProtQA huggingface dataset:
Protein: RL2_STRP8
Sequence: MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVSLKSKAGRNNNGRITVRHQGGGHKRHYRLIDFKRNKDGVEAVVKTIEYDPNRTANIALVHYTDGVKAYIIAPKGLEVGQRIVSGPDADIKVGNALPLANIPVGTVVHNIELKPGKGGELVRAAGASAQVLGQEGKYVLVRLQSGEVRMILGTCRATIGTVGNEQQSLVNIGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNEK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: GRPE_SHEAM
Sequence: MSNESTNPQQEPLEQVQDTEVVTDEAALVDELTQANFRIEELEQALAAAEAKVEEQKDSVVRAAAEVDNIRRRAAMDVEKANKFALEKFANELLPVLDNMERALAGTNAEDEATKAMYEGVSLTMKTLVNAVEKFGVKVVDPMGQPFNPEQHQAIGMQPNPEVPANHVMVVLQKGYELNGRLLRPAMVMVSQGGGVDTQA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAAB_METPE
Sequence: MVNTERFIQQAVSEIRELTADARVVMALSGGVDSSVCAALAAQAIGERLEPIYVDTGLMRKGETDRIRHLFGHLNLRIVDASDEFLDALAGVADPETKRKIIGERFIRVFEREAEKTGATVLLQGTIYPDRIESEGGIKSHHNVGGMPLGIAFTQVLEPLRDLYKDEVREVAGALGLPREIQHRMPFPGPGLAVRIIGEVTREKVAVIREANAITEEELVEEFRPWQCLAALVGLGTGVKGDIRLHGWIVAVRAVNSRDGMTADPLEVPYPVLFKIASRITAEIPSVARVVYDVTPKPPATIEYE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase.
Protein: LPTD_HAES1
Sequence: MKKNYYTVLSLSILTALYSTSSQANLQQQCLIGVPHFQGEIVQGDPNELPVYIEADHAKMNQSTHAQYEGNVNVKQGNRHLTAGMIEIEQHGKDNAKRYAYAKNGFDYKDNLIQLNGDNAKIHLDSKDANIQDADYQLVGRQGRGTADEVELREHYRVMKNATFTSCLPNSDAWSIEAKEMRQHIQEEYAEMWHARFKVSGIPIFYTPYLQLPIGDRRRSGLLIPKAGISTRHGYWYAQPFYWNIAPNFDATFTPKYMSHRGWQLNAETRYLTRIGEGKFVVEYLKTDRHSDSLNTARSRHLFYWGHNSHFLKDWRLNVNYTKVSDKHYFNDFESEYGNSTDGYVDQQASISYYQPNYNLSISAKQFQIFDKVDIGPYRALPQIDFNYYRNEIANGLVDFSLFSQVVRFDNDSALMPTAWRFHIEPSLTFPLSNRYGSLNIETKLYATRYLQKRGKGENAEEIKKTVNRVLPQIKLDFQTVLANRQSFIEGYTQTLEPKFQYLYRPYKDQSDIGLKQQNNDYLGFGYDSTLLQQDYFSLFRDRRYSGLDRIVSANQITLGGTTRFYDKNANERFNLSIGQIYYLKDSRTDNNPQNMAQGRSSSWSLESNWRINSKWNWRGSYQYDTHLNQTSLANTVLEYNSEKNNLIQLSYRYVNQSYIDQNLIGKNTYGQSIKQLGMTTAWELTDHWTLVGRYYQDLALKKPVEQYLGIQYNSCCWSIGVGARRYVTNRANQRNDEVLYDNSLSLTFELRGLSPSDHKNNIDEMLKKGKLPYIKAFSLY
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: GGTC_SYNY3
Sequence: MYVTPALLFLSAYLILPTLETVYLSFFDGRSRNFVGLKNYVFAFTDHTMLVAFRNNLLWLVLVTGISVSLGLIIAVLVDKVRYEAIAKSIIFLPMAISFVGASVIWKFVYAYRPAGAEQIGLLNAIVTSLGFAPVGWLVERSVNNFALIAIMIWLYTGFCMVILSAAVKGIPADVIEAARIDGANSWQIFWRITIPMIRSTLLVVSTTMVILVLKVFDIVFVMTGGNQGTEVIASLMIKEMFNYRNFGRGSTIAVILLLLIVPVMITNIRRFKAQEKLR
What is the function of this protein?
Part of the ABC transporter complex GgtABCD involved in the uptake of the osmoprotective compounds glucosylglycerol (GG), sucrose and trehalose (PubMed:11081796).  Responsible for the translocation of the substrate across the membrane (Probable).
What are the official names of this protein?
Osmoprotective compounds uptake permease protein GgtC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PARD1_MYCTO
Sequence: MGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADASRGR
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Antitoxin ParD1.
What is the protein family that this protein belongs to?
Belongs to the ParD antitoxin family.
Protein: ENL20_ARATH
Sequence: MMGKYLWALVYVTVMILIIVVEVESSLHRVGGGRYTWNSDVNFSDWANHQRFYSGDWLYFGFNRTRHNILQVNKSSYEQCVDNDYIFNITRGGRDVFQLLEPKPYYFICGRGYCLKGMKLAITVLPQPPPSAPTNFTSTTTPLIPPNAITAAILIFAFKALLL
What is the function of this protein?
May act as a carbohydrate transporter.
What are the official names of this protein?
Early nodulin-like protein 20, AtENODL20, Phytocyanin-like protein ENODL20.
What is the protein family that this protein belongs to?
Belongs to the early nodulin-like (ENODL) family.
Protein: RL36_MYCS2
Sequence: MKVNPSVKPICDKCRVIRRHGRVMVICSDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: WHIA_STAAW
Sequence: MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: IF1_MESM1
Sequence: MAKDAIKMTGKVIKAYNTDEYDVELENGIVVRAHISGKIRVHHITILRGDTVDVELSTYDLTKGRIVYRHR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
Protein: FPTB_PSEAE
Sequence: MPRQSGFGWAWRVPLALAGSLAAATASGYLLTRGLPLDDPLERLYAGLFGALGVGLLLLVGGLLARGPGNFAWRLGGSLLVLGLALWLLAGRG
What is the function of this protein?
May play some role in transport of Fe(3+)-pyochelin.
What are the official names of this protein?
Protein FptB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SHE10_ASHGO
Sequence: MRAISKLFVFTVLVLGSLQYYCGRYGACPAQIAVISHYTWPCTYAPAVRDKLGKASEWYGANAAPHVSVASGWMQGKVMPHLTKVSQWTEKHVQPRMRQAGADAIVTARVAWNVVQQYQRRHVVPLTGRLLAKCPCLERWAEQAARGWQWLCKHARALATAVQQQYPAFVAHMGGIWEPLHGAYNRIYLDLGRPVQEKTSEDASAAPGGTQYITSTITMTMTSLDELVTVTAEDGLSDVVEASFKDLVADEFSAWQQAIERKADSVLQAFTEEVGEFEMQQHEAVAPKFRALLKHISAKSQEHYAKINQAIRDINSTMELDPATNQTIWFDAHGTQLHQYITRPLMREYFSQANDELANITNHIRAELREVVDSVNGQVDVIRQEHIEVYEEWADVMVSEWSRRMAYIDVVDRDLEAEAERNRNWKRFLKLKKRVIKVRDQLLEHPVKFNQLETFLKEIQSTLRILAQENGEYLYILRSKANLSFQEREKNDRLREQHEQEAREMTLREQLSTELAANGTEVIIDTFEVDLDQLLRSNSTSWSVPPADARAEPASGSPIQQAASEAAQQPSV
What is the function of this protein?
Involved in spore wall assembly.  May be a component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria.
What are the official names of this protein?
Outer spore wall assembly protein SHE10, Sensitivity to high expression protein 10.
What is the protein family that this protein belongs to?
Belongs to the SHE10 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ILVD_YERPS
Sequence: MPKYRSHTTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIVASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLIDAMIQGANPNVSDEESAQIERSACPTCGSCSGMFTANSMNCLNEALGLALPGNGSLLATHADRKQLFLDAGKYIVALTKRYYEQDDVSALPRNIANKAAFENAMILDIAMGGSTNTVLHLLAAAQEGEIDFSMTDIDRLSRKVPHLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVSNVLGLNLTQTLEAYDVMLTQDEGVKQMYAAGPAGIRTTKAFSQDCRYPSLDTDREEGCIRTREHAYSQDGGLAVLYGNIAADGCIVKTAGVDKDSLTFRGPAKVFESQDEAVEAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHVSPEAASGGLIGLVQDGDFINIDIPNRGIVLDVSEAELAARRETEEAHGDAAWSPKGRERQVSYALRAYAMLATSADKGAVRDKSKLGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: TRMFO_STRPB
Sequence: MSQSTATYINVIGAGLAGSEAAYQIAKRGIPVKLYEMRGVKATPQHKTTNFAELVCSNSFRGDSLTNAVGLLKEEMRRLDSIIMRNGEANRVPAGGAMAVDREGYAESVTAELENHPLIDVIRDEITEIPDDAITVIATGPLTSDALAEKIHAVNGGDGFYFYDAAAPIIDKSTIDMSKVYLKSRYDKGEAAYLNCPMTKEEFMAFHEALTTAEEAPLNSFEKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQLRQDNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLTETFQSRNNPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKREEALVFPQTTAIGSLPHYVTHADSKHFQPMNVNFGIIKELEGPRIRDKKERYEAIASRALADLDTCLASL
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSCL_ESCF3
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLTEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NBPFB_HUMAN
Sequence: MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNLKERCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKGKKIKTHHAPGSAAC
What are the official names of this protein?
Neuroblastoma breakpoint family member 11, Neuroblastoma breakpoint family member 24.
What is the protein family that this protein belongs to?
Belongs to the NBPF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOR2_BOMMO
Sequence: MNILKLFFVFIVAMSLVSCSTAAPAKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
What is the function of this protein?
Has antibacterial activity against Gram-positive and Gram-negative bacteria.  Probably acts by disturbing membrane functions with its amphipathic structure.
What are the official names of this protein?
Moricin-2.
What is the protein family that this protein belongs to?
Belongs to the moricin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SDHB_BACSU
Sequence: MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIRRNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKTFPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGVCLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNCVQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV
What are the official names of this protein?
Succinate dehydrogenase iron-sulfur subunit.
What is the protein family that this protein belongs to?
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
Protein: OMPA_NEIMA
Sequence: MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGEGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPAQNSKSAYKPAYWTTVNTGSATTTTFVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRDAFELFLLGSGSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF
What is the function of this protein?
Serves as a slightly cation selective porin.  Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity.
What are the official names of this protein?
Major outer membrane protein P.IA, PIA, Protein IA, Class 1 protein.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: PER1_ARAHY
Sequence: MALPISKVDFLIFMCLIGLGSAQLSSNFYATKCPNALSTIKSAVNSAVAKEARMGASLLRLHFHDCFVQGCDASVLLDDTSNFTGEKTAGPNANSIRGFEVIDTIKSQVESLCPGVVSCADILAVAARDSVVALGGASWNVLLGRRDSTTASLSSANSDLPAPFFNLSGLISAFSNKGFTTKELVTLSGAHTIGQAQCTAFRTRIYNESNIDPTYAKSLQANCPSVGGDTNLSPFDVTTPNKFDNAYYINLRNKKGLLHSDQQLFNGVSTDSQVTAYSNNAATFNTDFGNAMIKMGNLSPLTGTSGQIRTNCRKTN
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Cationic peroxidase 1, PNPC1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: WASL_MOUSE
Sequence: MSSGQQPPRRVTNVGSLLLTPQENESLFSFLGKKCVTMSSAVVQLYAADRNCMWAKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDAPNGPNLPMATVDIKNPEITTNRFYGSQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHSSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPGVVVPPPPPNRMYPPPPPALPSSAPSGPPPPPPPSMAGSTAPPPPPPPPPPPGPPPPPGLPSDGDHQVPAPSGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVSDGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDDDDEEDFEDDDEWED
What is the function of this protein?
Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex.  Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization.  Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia.  In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity).  Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (PubMed:12871950).  Plays a role in dendrite spine morphogenesis (PubMed:25851601).
What are the official names of this protein?
Actin nucleation-promoting factor WASL, Neural Wiskott-Aldrich syndrome protein, N-WASP.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (PubMed:12871950, PubMed:14676198). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (PubMed:12871950).
Protein: LIPA_PELPD
Sequence: MDVQPTTMRGAVKTAHLGTDVSLATKPLPKPEWLRGKSASTPDVERLVRILRDNRLHTVCEEASCPNLGECFRKGTATFMIMGDVCTRHCPFCNVAHGSPHELAADEPVNLARAVELLKLSYVVITSVTRDDLPDGGAGHYGACVRALRDLKRSLKVEILTPDFRGAVAVAFEELRMNLPDVFNHNLETVPRLYPRVRPQADYHGSLDLLLRFREQFDHVPTKSGLMLGLGETEQEVRDVMEELRRHRCDMLTLGQYMRPSPHHLPVERYVTPDEFERYRQFGLSIGFSHVESGPMVRSSYHADMQARELMLVN
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEY_DROME
Sequence: MDHNMHVNAPSLHHWGYAAGPGVVMPGATATTPQSHWVPPPQSHHSAHSNHSHGHSQGHSHGIGSLKRTLSESDCDDLYSEESSKEQISPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSLQSKTLDSLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRELSAKSCASPGGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLSASPSQQAQQLGGRTSVSRTSGSAVTESLPSHDLHSDSSSQQQQQQQQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQQHYTHDHSAVHSEQQVPTYIELTNSNRPAAIGSDSLSYSAAPQYPVSGLPGQDYNNSSVLQYATPNGAKPYRPWGAEMAY
What is the function of this protein?
Transcriptional repressor which acts as a downstream effector of Notch signaling.
What are the official names of this protein?
Hairy/enhancer-of-split related with YRPW motif protein.
What is the protein family that this protein belongs to?
Belongs to the HEY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DUT_MYCBP
Sequence: MSTTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAVAVPFGMVGLVHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGDRIAQLLVQRVELVELVEVSSFDEAGLASTSRGDGGHGSSGGHASL
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RS4_CHLT3
Sequence: MARFRGSITKVSRRLGVALAPKAEKYLGRRAYAPGQHGQSRKGKISEYALQLREKQKMKYIYGVLERQFRNYYKKAVSQRGVTGENLVKLLECRFDNVVFRAGFSPSRAGARQLVSHCHLRINGNKVNIPSYQVKPGDVIDFREKSRNMDAVRNSLNKTPDSRIPQWIQVDKANMKAVFLNVPERADIQEPYNEQLVVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: VIF_HV1BR
Sequence: MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARGWFYRHHYESPHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSPRCEYQAGHNKVGSLQYLALAALITPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: EFG_CHLT3
Sequence: MPRQIPLEKVRNIGIMAHIDAGKTTTTERILYYTGRVHRLGEVHDGAATMDWMEQEKERGITITSAATTCFWQPRYGLLKDVRHRVNIIDTPGHVDFTVEVERSLRVLDGAVAVFCAVGGVEPQSETVWRQANKYKVPRIGYVNKMDRVGADFFNVVEMIKERLKANPVPIQIPIGQGEMFAGFIDLIRMKGIIYDKEDGTTYQEVEIPHDLENQAKTWRVNMLEAVSDIDDSLLEKYLNGEEITEEEVRRTLRVATLKTEIIPVLCGSSFKNKGVQFMLDAVVEYLPSPIDVGAVTGHSPRDEDEKIARQPDDSAPFAGLAFKITSDPYVGKLTFFRVYSGVLKSGSYVLNSITGKKERIGRLLQMHANHREDLDEVFAGDIAAAVGLKDTKTGDTLCDESKSIVLEKMVFPEPVIQIAIEPKTKADSDKLGMSLAKLAEEDPTFKVSMNEDTNQTLIAGMGELHLEIIVDRLKREFKVDANVGKPQVSYKETIRKKVEAEGKFVRQSGGKGQFGLVNIIVEPSEKDKGFEFVNEIKGGSIPKEYIPAVSQGIQEAMRNGIVAGYPMIDVKVTLFDGKYHEVDSSEMAFKIAGSIGFKEGARKAGAVLLEPIMAVEVITPEEYMGDVMGDLSGRRGHIEGMHQRAGAQVIKAKVPLSAMFGYSTELRSMTQGRANYSMEFHDYSEVPASIANEIVEKSSGKVTA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZG58_XENLA
Sequence: TGEKPFTCKECGKSFKTKQILCTHELSHTGEKPYVCIECGKGFYQKGHLNVHSLVHSTKKPFICTECGKTFIVKQLLHEHFLIHTGEKPYACPECGKLFRLKQLLTSHLLTHTGLKPYTCPECGKRFAFRGNFYQHLHLHTGDKPFSCTECGNCFATKVQLQRHHLLHTGEKPFVCTECNLSFAGLANLRSHQHLHTGEKPYKCTECGKCFRFKGHLTSHMKIHSGIKAFICTECGKEFTHKYSLRKHQRIHTSEKPYVCTECGKSYKQRRSLNDNLRIHTGEKPFACTECNKTFLSASCLQAHKQTHTGLKPFQCNECGQLFSRKGNSNVHLQSHTGEKPYTCAECGKSFTTKVTLNHHRYTHTGKKPYPCTECGKCFRQKYELRCHQYSHTGENPFECTECGKSFPSRARFNRHRNIH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Gastrula zinc finger protein XlCGF58.1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.