PharMolix/UniProtQA huggingface dataset:
Protein: RSMA_SHEPC
Sequence: MSNKVHLGHTARKRFGQNFLTDGNVINRIVGAIAPDNNHVMVEIGPGLGALTEPVAMAVDNLTVVELDRDLVERLHKHPVLKDKLTIHQGDALQFDFSQLVVPGKKLKVFGNLPYNISTPLMFHLFEFAEQIETMHFMLQKEVVLRLSASPGCKAYGRLTVMAQYFCQVVPVLEVPPHSFTPAPKVDSAVVRLLPYAEKPFPCKDVNVLRQLCTTAFNMRRKTLRNNLKHMLSDAEFEQLGIDQSQRPEQISVEQYVAMANMICDRKA
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYRA_BUCBP
Sequence: MKEVAKEIIKIDIEDELKNSYLDYAMSVIIGRALPDVRDGLKPVHRRILFAMKVLNNDWNKTYKKSARIVGDVIGKYHPHGDTAVYDAIVRMAQPFSLRYVLIDGQGNFGSIDGDSAAAMRYTEIRMSKIAYELLNDLDKNTVSFFSNYDGTEKIPEVLPAKIPNLLINGSSGIAVGMATNIPPHNIKEVINGCLAFIDDQNITLKKLMEHIPGPDFPTAGLINGKRGIEKAYKTGKGKIYIRAKSIIEIQKKTKKKSIIIYELPYQVNKARVIKGIANLVKEKKIEGITTLRDESDKEGMRIVIEIKKETKAEIILNQLYSLTQLEISFGINMVALIHGQPKVMTLKEILNAFINHRRKIIMRRSLFELNKIRKKIHILEGLIISLDNIDLIINLIKKSSTLEEAKNKLKTYHWYSKHAQYTQILKKNAHSLTPYDKKLRPIDTQKFFLTPEQIQAILELRLQKLTHLEHKKLISEYKQLFKTSNNLENILKNNNILTKIMKDELIKIRDNFGDKRRTKINVNYSDINTSDLINKENVVITLSYSGYVKYQLLSSYEAQKRGGKGKLAVKTKEEDFIENLLVANTHDIILCFSSKGILYWMKVYQLPEASRHARGRPIVNLLPLSSNERITAILPISEYKDSINIFMATSKGMVKKTSLYEFKKPRTKGIIAINLKADDELIGVSLTNGNNTIMLFTAQGKAVHFSEILVRKTGRTAIGVQGIKIKKSDKVVSLVVPKKHGNILLITEHGYGKRTEIHEFPIKSRATQGTIAMKITKKNGIVIGTMQVVNQDQIIIITNAGTLVRTRVLEIGILGRNTQGVIIIRTSKKEKVVALQKANALHLNSV
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_RUBXD
Sequence: MQVILTQDVEKVGRRGDIVDVSRGYVRNYLVPRGLAEVATPAKLEEARRRMEEAAERERRLAERAEEIAETLNKSVITIEARTGEDERLFGSVTAANIAEAIEKARGIHLDRRKIRLEEPIRSLGTHQVPVQVHGEIEASVKVIVVPKL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: NU5C_LIRTU
Sequence: MEHTYQYAWIIPFVPLPVTMSIGLGLLLVPTATKNLRRMWAFPSVSLLSIVMVFSADLSIQQINGSSIYQYLCSWTINNDFSLEFGHLIDPLTSIMSILITTVGIMVLIYSDNYMSHDQGYLRFFAYMSFSNTSMLGLVTSSNLIQIHIFWELVGMCSYLLIGFWFTRPIAANACQKAFVTNRVGDFGLLLGILGFYWITGSLEFRDLFEIFNNLIHTNGVNSLFATLCAFLLFVGAVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLVARLLPIFTVIPYIMNLISLLGIITVLLGATLALAQKDIKRSLAYSTMSQLGYTMLAPGIGSYRAALFHLITHAYSKALLFLGSGSIIHSMEPIVGYSPDKSQNMVLMGGLTKYVPITKTTFLLGTLSLCGIPPLACFWSKDEILNDSWLYSPIFAIIACSTAGLTAFYMFRMYLLTFEGHLHIRFQNYSGTKNSSFCSISIWGKEGPEPVKKKLLLSVMNNNQKVSFFSKKIYQIDGNVRNLMRSFSTHFDNKDTSMYPCESDNTMLFPLLVLVLFTLFVGSIGIPFDQVGSDFDILSKWLTPSINLLHQNSNYSVDWYEFVTNAIYSVSISYFGIFIASLLYGSVYSSFQNLDLINSFVKIGPKRLFLDRIINVIYNWSYNRGYIDVFYATFLTKGIRGLAELTNFFDRRVIDGITNGVGIASFFVGEGIKYVGGGRISSYLFVYLSYVSTFLLIYYFYFLNR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GLGB_FRACC
Sequence: MNNGDVNNGTARTGRLATGLAPDRPNPRGAATAVRNGGGRVALADRDASSASAQPGQTADDPAVPSAPPSAPPSALPADPPAVAPAVSVDLPYDDLERLVSGAHHDPHALLGAHPHPGSDATVVRVLRPDARAVTVLVGPARYPATRLHSGGVFGVAVPGMLPDYRIEVTYPDGPYLIDDPYRHLPTLGEMDLHLIIEGRHEQLWKVLGAHPRALTTPGGATVTGVSFAVWAPSARGVRLVGDFDFWDGRAFPMRSLGRSGIWELFVPGAGTGARYKYEILGFDGIWRQKADPLAFHTEVPPATASVVFASDFTWNDGAWLDRRARTAWRTEPVSVYEVHLGSWRRGLSYRELAEELTAYVVENGFTHVEMLPVAEHPFGGSWGYQVSAYYAPTARFGSPDEFRHLVDTLHRAGIGVIVDWVPAHFPRDTWALGRFDGTPLYEHPDPRRGEQPDWGTYVFDLGRPEVRNFLVANALYWFEEFHIDGLRVDAVASMLYLDYSRPEGGWLPNIHGGRENLDAVSFLQETNATVYRRFPGAMMIAEESTAWPGVTRPTHLGGLGFGFKWNMGWMHDTLDYNSRLPIHRMYHHHQMTFSMVYAYSENFILPFSHDEVVHGKGSLLRKMPGDRWAQLANLRALLAYMWAHPGKKLLFMGCEFAQDNEWNESASLEWPLLDDPAHAGVADLVRDLNGLYRTVPALYQHDADPAGFSWIDANDAENNVFSFLRWSGEDPAGGVLACVTNFAGIGHEGYRIGLPFPGRWREILNTDGYRYGGGNIGNLGSVQAVEEPHHGLDASATLTLPPLGAIWLSPA
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: FBLN3_RAT
Sequence: MLQTVFLTMLTLALVKSQVTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETPAAEASSGAATGTIAARSMATSGVIPGGGFIASATAVAGPEVQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTSGTHNCRLDQVCINLRGSFTCHCLPGYQKRGEQCVDIDECSVPPYCHQGCVNTPGSFYCQCNPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPQNPCQDPYVLTSENRCVCPVSNTMCRDVPQSIVYKYMNIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLTGPREHIVGLEMLTVSSIGTFRTSSVLRLTIIVGPFSF
What is the function of this protein?
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways.  May play a role in cell adhesion and migration.  May function as a negative regulator of chondrocyte differentiation.  In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
What are the official names of this protein?
EGF-containing fibulin-like extracellular matrix protein 1, Fibulin-3, FIBL-3, T16 protein.
What is the protein family that this protein belongs to?
Belongs to the fibulin family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=Localizes to the lamina propria underneath the olfactory epithelium.
Protein: ATPE_BACC2
Sequence: MKTFPVSIVTPDGPVYEKEVEMVSVKAESGEMGILPGHIPTVAPLKISAVRLKNGGHTDYVAVSGGFIEVRPDKVTVLSSSAEEANHIDIHRANEAKRRAEQRMQDKQAHVDFKRAEMALQRAVNRLNVSDMK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FDHD_ACIAD
Sequence: MDSLTETTNALSNDTHAQGYQSVSTTRHVGHIREVVYDCVVEEFPVALIYNGISHAVMMTTPLDLEVFAIGFSLTEAIIDHPRQIYDIEIIKSDLGIQVEITIASEAFIKLKTHRRTLAGQTGCGICGIESLQQIQHTFPPVTHDFFVHWLDQIPDAMVQLQQQQPISAVTGGAHAAAWVVNGNILTVFEDVGRHNALDKLLGHLVKHDIDRSQGFVLMTSRASYELVKKCAQLNISLLATISAPTSLAIELAKRSGLKLASFCRQSRYVVYS
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_ALIB4
Sequence: MVSLTSYAFVSMMLFSIGAIGVIARKNIFVIYMSIEMMLNGINLFLITFARYHFNIDPQIITVMVISIAAAEAAIFLSVIILLFRSKKSLNTDVFTSLTQGEN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QCRC_MYCLE
Sequence: MKKLGFTRSSRRCSQPQEREQESERSRRRLRRRLSEGLLLLVALTVSGGLAAVLTPTPQVAVADEDSSALLRTGKQLFDTSCVSCHGANLQGVPDHGPSLIGVGEAAVYFQVSTGRMPAMRGEAQVARKDPIFNESQIDAIGAYIQANGGGPTVARNPDGSVAMQSLRGTDLGRGGDLFRLNCASCHNFTGKGGALSSGKYAPDLGPANEQQILTAMLTGPQNMPKFADRQLSFEAKKDIIGYVRTVIEERQPGGYSLGGFGPAPEGMAIWIIGMVTAIGLALWIGARA
What is the function of this protein?
Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis.  The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain.  The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
What are the official names of this protein?
Cytochrome bc1 complex cytochrome c subunit, Cytochrome bc1 reductase complex subunit QcrC, Ubiquinol--cytochrome c reductase cytochrome c subunit.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSMH_PERMH
Sequence: MVEHYPVLHREVLSFFKNIKGRYIVDATVGGGGHSFLLLKNLPETFLIGIDKDDYALEKAEEKLSPFKGRFRLIKGSFKDIDTIVHSMDIKYVSGVLFDLGVSTFQLKTERGFSFQREEPLDMRMDRTQKKTAFDVVNRYTKIELEKIIKDYGEEKFARRIASAIVEARKKKRIETTKELAQIVYNVYPPPLRRGRIHPATKTFQAIRIEVNNELEEIKEGVNKGIDLLEKGGIIAVISFHSLEDRIVKNIYRERKRLKDIEILTKKPITPGTEEIRENPPSRSAKLRVAKRI
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y027_BACC3
Sequence: MMRGGMGNMNNMMKQMQKMQKEMAKAQEELGEKTVEGTAGGGMITVIANGHKQILEVKVKEEVVDPEDIEMLQDLVLAATNDALKKADELSNSTMGKFTKGLNLPGGMF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein BCA_0027.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: BRZ_HALS3
Sequence: MPITDLHCPRCGSDVKMGLPMGATVKSVTAASRQEPTSDTQKVRTVECRNDHEFFVRFEW
What is the function of this protein?
Activates transcription of bacteriorhodopsin (bop) and phytoene synthase (crtB1).  May interact with DNA or RNA via the zinc finger motif.
What are the official names of this protein?
Transcriptional regulator Brz, Bacteriorhodopsin-regulating zinc finger protein.
What is the protein family that this protein belongs to?
Belongs to the Brz family.
Protein: CEDA_SALPA
Sequence: MMKPLRQQNRQIISYIPRVEPAPPEHAIKMDTFRDVWILRGKYVAFVLTGESFQRSPAFSVPESAQRWANQVRQENEIAD
What is the function of this protein?
Activates the cell division inhibited by chromosomal DNA over-replication.
What are the official names of this protein?
Cell division activator CedA.
What is the protein family that this protein belongs to?
Belongs to the CedA family.
Protein: IL10_ORCOR
Sequence: MPSSALLCCLIFLARVAAGQHQGTQAKDSCIHFPDSLPHMLRELRAAFSNVKTFFQMNDQLDNSLLSQSLLEDFKGYLGCQALSEMIQFYLEEVMPKAEDHGPNIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEQVKSVFNKLQEKGVYKAMREFDIF
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENO2_CHLTE
Sequence: MSVITRIHARQIMDSRGNPTVEVDVHTESSFGRAAVPSGASTGVHEAVELRDKDKSVFLGKGVLKAVENVNTLINDALLGMDVTEQEAIDAKLIELDGTPNKSKLGANAILGVSLACAKAGAEYSALPLYRYIGGTTAKTLPVPMMNVLNGGAHADNTVDFQEFMIMPIGFERYSDALRCGAEVFHSLKSLLHDRGLSTAVGDEGGFAPNVESNEQAIELVIEAIGMAGYKAGAPTDRGGLGDGHVMIALDPASSEFYDAEKKKYVFKKSSGRELSSEEMASYWADWASRYPIISIEDGMAEDDWEGWKMLTDKIGGRVQLVGDDLFVTNSKRLAEGIEKGVGNSILIKVNQIGTLTETLQAIELAKRNGYTSVISHRSGETEDTTIAQIAVATNAGQIKTGSMSRSDRMAKYNELLRIEEELGSTALYPGIGAFRV
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase 2, 2-phospho-D-glycerate hydro-lyase 2, 2-phosphoglycerate dehydratase 2.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: ITAL_BOVIN
Sequence: MNSCIIVLRLLLSGPFVFAPAWSYNLDVRHVQNFSFPLAGRHFGYRVLQVGNGVVVGAPSEGNSMGNLYQCQPETGDCLPVTLSSNYTSKYLGMTLATDPTSDNLLACDPGLSRTCDQNIYLSGLCYLIHENLRGPVLQGHPGYQECIKGNVDLVFLFDGSMSLQQDEFEKIVDFMKDVMKKLSNSSYQFAAVQFSTYFRTEFTFLDYIRQKDPDALLAGVKHMRLLTNTFGAINYVAKEVFRPDLGARPDATKVLIIITDGEATDEHNIDAAKDIIRYIIGIGKNFKTKESQEALHQFASKPVEEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSEGHGVVGAVGAKDWAGGFLDLKADLKSSTFVGNEPLTVESRAGYLGYTVTWLPSRGTMSLLATGAPRYQHVGRVLLFQQPKRGGPWSQIQEIDGIQIGSYFGGELCGVDVDRDGETELLLIAAPLYYGEQRGGRVFIYQKIQLEFQMVSELQGETGYPLGRFGAAIAALTDINGDELTDVAVGAPLEEQGAVYIFNGQQGGLSPRPSQRIEGTQMFSGIQWFGRSIHGVKDLGGDGLADVAVGAEGQVIVLSSRPVVDIITSVSFSPAEIPVHEVECSYSTSNQKKEGVNLTVCFQVKSLISTFQGHLVANLTYTLQLDGHRTRSRGLFPGGKHKLIGNTAVTPVKSCFVFWFHFPICIQDLISPINVSLSYSLWEEEGTPRDPRALDRDIPPILKPSPHLETKEIPFEKNCGEDKNCEADLKLAFSDMRSKILRLTPSASLSVRLTLRNTAEDAYWVQVTLSFPQGLSFRKVEILKPHSHVPVGCEELPEEAVVHSRALSCNVSSPIFGEDSMVDIQVMFNTLQKGSWGDFIELQANVSCNNEDSSLLEDNSATTSIPVMYPINVLTKDQENSTLYISFTPKSPKIHHVKHIYQVRIQPSNYDNMPPLEALVRVPRVHSEGLITHKWSIQMEPPVNCSPRNLESPSDEAESCSFGTEFRCPIDFRQEILVQVNGMVELRGTIKASSMLSLCSSLAISFNSSKHFHLYGRNASMAQVVMKVDLVYEKEMLYLYVLSGIGGLLLLFLIFIALYKVGFFKRNLKEKMEANVDASSEIPGEDAGQPELEKECKDPGCLEPLQKTDEDGSGGD
What is the function of this protein?
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4.  Integrin ITGAL/ITGB2 is a receptor for F11R.  Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL.  Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.  Contributes to natural killer cell cytotoxicity.  Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils.  Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis.  Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
What are the official names of this protein?
Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain.
What is the protein family that this protein belongs to?
Belongs to the integrin alpha chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: EFG_MAGSA
Sequence: MARTTPLERYRNIGIMAHIDAGKTTTTERILYYTGKSYKIGEVHEGTATMDWMEQEQERGITITSAATTAFWRDHRVNIIDTPGHVDFTIEVERSLRVLDGAVTVFDSVAGVEPQSETVWRQADKYGVPRICFVNKMDRIGANFYRCVDMIVDRLGARPLVMHLPIGEESGYIGLVDLLRNVAVIWKDESLGAEFEDQPIPADLVEKAAQYRAQLIETAVEMDDEAMEQYLGGEEPSFEVLQACIRKGTISRTFVPVLCGSAFKNKGVQPLLDAVIDYLPAPVDIPAIKGVKYGTEDEIAKHSTDDEPFAGLAFKIMNDPFVGSLTFVRVYSGVVESGSYIQNTVKEKRERVGRMLLMHANSREEIKEARAGDIVAFAGLKDTTTGDTLCDPTPSSLVVLERMEFPEPVIEVAVEPKSKADQEKMGIALARLAAEDPSFRVTSDVESGQTVIKGMGELHLEILVDRMKREFKVEANVGAPQVAYRETISKAYEVDYTHKKQTGGSGQFARVKIRFEPGEKGAGYVFENKVIGGSVPKEYVPGVDKGIRSAMDNGVIAGFPMIDFKATLTDGAYHDVDSSVLAFEIASRAAFREGIAKAGPKLLEPMMKVEVVTPEDYLGDVIGDLNSRRGQVNDMDQRGNARVITAMVPLANMFGYVNTLRSMSQGRAQYSMTFDHYSEVPQNVSDEIRAKLAG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_CLOTE
Sequence: MKNIILEIEEKIYSDEDITFNEAITLFQSSYDKNLNNLLDAANRIRNKFNGNIVDLCSIMNAKSGRCSEDCKFCAQSEHYNTNIKKYNMINMSDALNLAKENKEHGINRFSLVTSGKALTSNDFEKALEIYKEINKRVNINLCASLGILSYNQLLQLKNVGVTMYHHNLETSREYYNKICTTHSYDERIETINNAKKAGLMVCSGGIIGMGETITDRIKLAFELKSLQIQSIPINILNPVKGTPLEYTKRLEQNDILKTIAIFRFINPKASIRLAGGRNLIDNFGKGCFRAGANATISGNYLTTSGNKINDDIEMIKSLGLSLDI
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: CYB_TAMTO
Sequence: MTNIRKTHPLIKIINHSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTYFETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVMVHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDILGVLLLILVLMILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILMLFPILHMSKQRSMMFRPLSQCVFWILVADLFTLTWIGGQPVEYPFIIIGQLASILYFMIILLILPAISLFENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CENPB_HUMAN
Sequence: MGPKRRQLTFREKSRIIQEVEENPDLRKGEIARRFNIPPSTLSTILKNKRAILASERKYGVASTCRKTNKLSPYDKLEGLLIAWFQQIRAAGLPVKGIILKEKALRIAEELGMDDFTASNGWLDRFRRRHGVVSCSGVARARARNAAPRTPAAPASPAAVPSEGSGGSTTGWRAREEQPPSVAEGYASQDVFSATETSLWYDFLPDQAAGLCGGDGRPRQATQRLSVLLCANADGSEKLPPLVAGKSAKPRAGQAGLPCDYTANSKGGVTTQALAKYLKALDTRMAAESRRVLLLAGRLAAQSLDTSGLRHVQLAFFPPGTVHPLERGVVQQVKGHYRQAMLLKAMAALEGQDPSGLQLGLTEALHFVAAAWQAVEPSDIAACFREAGFGGGPNATITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAMVKRYLTSFPIDDRVQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS
What is the function of this protein?
Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497).  May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable).
What are the official names of this protein?
Major centromere autoantigen B, Centromere protein B, CENP-B.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere.