PharMolix/UniProtQA huggingface dataset:
Protein: PARL_DROME
Sequence: MLMSRALCRSWLPQVARRCHANVNVPILRINSGHPAARSCRQIHSNRKQSSNLKPTTGEPAAAEQNTPVPVNNVIKAVAFTGAFTVGCFAGATILEYENTRSLILEKARQARFGWWQSRSLADRDYWTQIKQDIRRHWDSLTPGDKMFAPILLCNLVAFAMWRVPALKSTMITYFTSNPAAKVVCWPMFLSTFSHYSAMHLFANMYVMHSFANAAAVSLGKEQFLAVYLSAGVFSSLMSVLYKAATSQAGMSLGASGAIMTLLAYVCTQYPDTQLSILFLPALTFSAGAGIKVLMGIDFAGVVMGWKFFDHAAHLGGAMFGIFWATYGAQIWAKRIGLLNYYHDLRRTKQK
What is the function of this protein?
Mitochondrial intramembrane protease which plays a critical role in the regulation of mitochondrial function (PubMed:16713954, PubMed:21945938).  Essential for mitochondrial development and fusion during spermatogenesis and the development of neurons and muscles (PubMed:16713954, PubMed:21945938).  Essential for proteolytic processing of Pink1 and HtrA2 into their mature forms (PubMed:19048081).  May also be involved, but not required, for the proteolytic processing of Opa1 (PubMed:19048081, PubMed:21945938).
What are the official names of this protein?
Presenilins-associated rhomboid-like protein, mitochondrial, Mitochondrial intramembrane-cleaving protease Parl, Rhomboid-7.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: XERS_STRT1
Sequence: MKRELLLEKIEEYKSLMPWFVLEYYQSKLSVPYSFTTLYEYLKEYKRFFNWLIDSGISDADDIASIHIKTLENLTKKDMESFVLYLRERPSLNTYSKKQGVSQTTINRTLSALSSLYKYLTEEVEGPDGEPYFYRNVMKKISTKKKKETLAARAENIKQKLFLGDETMKFLDYVENEYEVKLSNRAKSSFYKNKERDLAIIALLLSSGVRLSEAVNLDLKDINLKRMVIDVTRKGGQRDSVNMASFARPYLENYLSIRNKRYKAEKQDVALFLTEYRGVPNRIDASSIEKMVAKYSQDFKIRVTPHKLRHTLATRLYDATKSQVLVSHQLGHASTQVTDLYTHIVNDEQKNALDNL
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.
What are the official names of this protein?
Tyrosine recombinase XerS.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_KLULA
Sequence: MTESLSNSLKVQLRSADAKVPTKGSTTAAGYDIYASQPGVIPARGQGIAKTDISFTVPVGTYGRIAPRSGLAVKHGIQTGAGVVDRDYTGEVGIVLFNHSDKDFQINKGDRVAQLILEKIVEDAEIVVVESLEETQRGAGGFGSTGKN
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RL18_FINM2
Sequence: MFKKIDKNANRVKRHLRIRKNLTGTSEKPRLCVFKSNTNIYAQLIDDVNHNTLVAASTLDKDFSGESKSNKEAAKLVGELIGKKAIDKGIEQCVFDRSGYLYHGKVKELAEGARSAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CCME_MAGSA
Sequence: MTRKQRRLYFVLLGMAALGGAVALVLTAISDSLVYFYSPTDIVSQRIPEGRRMRIGGLVENDSVVKDGKTVTFKVTDVTNAVPVVYTGVLPDLFREGQGVVVEGRMEAGGHFKASEVLAKHDENYMPKEVAEALKKSGQWNDGKQPKQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: RL24_ECOSM
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: NIMR_ECOLI
Sequence: MMHRLNLNGYEPDRHHEAAVAFCIHAGTDELTSPVHQHRKGQLILALHGAITCTVENALWMVPPQYAVWIPGGVEHSNQVTANAELCFLFIEPSAVTMPTTCCTLKISPLCRELILTLANRTTTQRAEPMTRRLIQVLFDELPQQPQQQLHLPVSSHPKIRTMVEMMAKGPVEWGALGQWAGFFAMSERNLARLIVKETGLSFRQWRQQLQLIMALQGLVKGDTVQKVAHTLGYDSTTAFITMFKKGLGQTPGRYIARLTTVSPQSAKPDPRQ
What is the function of this protein?
Negatively regulates expression of the nimT operon and its own expression.  Acts by binding to the nimR-nimT intergenic region.
What are the official names of this protein?
HTH-type transcriptional regulator NimR, Regulator of nimT.
Protein: RL29_CORA7
Sequence: MATGTPAHEFRELDNAELENRLKDAKEELFNLRFQKATGQLTNNRRIGTVKRDIARIYTVLRERELGLSVAPGAEA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: Y5095_CITK8
Sequence: MDAPERLMPREKMLKSGIGSLTDVELLALFLRTGVPGKDVMALAHETLQRSGSLYGLLSADFAQFRGTGIGIAKYAQLKGIAELARRYYKARMMKENALLSPEMTREFLQSQLTGEEREIFLVIFLDARHRVIKHSRLFSGTLNHVEVHPREIIREAIKLNASAVILAHNHPSGCAEPSKADKLITERVVKCCQFMDIRVLDHLVIGRGEYVSFAERGWI
What are the official names of this protein?
UPF0758 protein CKO_05095.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family. YicR subfamily.
Protein: MURC_PARL1
Sequence: MRPAPLDIGNIHFVGIGGIGMSGIAEVMHNLGYTVQGSDLADSANVKRLKGLGIKVFIGQKAENLAEAQVIVVSSAIRADNPELMEARARFLPVVRRAEMLAELMRLKSCVAIGGTHGKTTTTSLVAAILDKAGLDPTVINGGIINAYGTNARLGGGEWMVVEADESDGTFVKLPATIAIVTNIDPEHLDYYGSFDAAKDAFLAFVENVPFYGAAVMCIDHPEVQALIGRVRDRRIVTYGTNPQADIRATNARVEDGFNVFDVAITDRKTGTAREMTGVRLAMHGTHNMLNSLAAIGVATQMGIADDKIRAALEGFGGVKRRFTFVGSWNDVNIYDDYGHHPVEIAAVLQAARSATKGRTIAVVQPHRYTRLHNLFDEFCACFNDADAVIVADVYEAGEKPIEGASRDALVEGLRDRGHRNVMALDGPEALPRLIAETARPGDLVVCLGAGSITYWANALPDDLAKLGGKKKAAAKSAAKTKAKPKKGRGK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMTR1_ALTAL
Sequence: MRSRTGCLTCRQRKLKCDEKKPVCRQCAKASRECIPSPGIVFRHQQNASMNGEDSTAEKSLKGFYAYKNTFDKDAMWVDIPKCITFVTTTNLYLDSGVLELDTMLATSMESPKPFEPHCLASWRTQGDRHPIGNVPSSLRSELAPSSVSCCLTQDVKALSPQIHSSPGSVIERPVSPPMSLFNPHIGLIMNLTTSSAMPSTDSFFSLPFDSTDYMPRPVSRPRLRWRPPRPNASILTQDEHEIACLLQWFSEGPGYWMDLFITGTYFASHVPVEAVENPLLKYAIAACAAKAFARVQDQKPAMGGSSTRQAGMKHYPNVPLVDWEHKTAVYYNTTVSMLLQALNGKVASSPNGSKCELRQRNGDPACAYNVSAPKPRRISQNTSFVPSTEELLVVIAILCFYEFLDTSISEWEKHLHGAKSFLVLSQQHIRSLRLPNLASPMFPTSSKFASKAWRAVFWNIARQDMLAAFINKTSTRLDTDDLTLWREAGLILDEQACIMPSNAAVYGYLEEGDAMIKEELICNTLVWLMVKLVNFMAVGSVIPSRSGAAWDGVVHRTRFCQWFSLRKQFQVWHEGLPVTFRPSARVAPSHTSGQVSNDDSASMFSEAWHSMPMCASTMQTYYMSQILLFMNKPHESTLECHTELIRMSYHQSVLAACQIHSRRIIGISLAQPDKAVRVHSVQPLFTAGQCLSDNRECQIVLRLLRDIESDTGWATDYRVQQLVEQWQRNEPDSQALWSDSRCAIPHENKYPSPTFNTVRLQHGSDLRSN
What is the function of this protein?
Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of AM-toxins, host-selective toxins (HSTs) causing Alternaria blotch on apple, a worldwide distributed disease (Probable).  AM-toxins have two target sites for affecting susceptible apple cells; they cause invagination of the plasma membrane and electrolyte loss and chloroplast disorganization (PubMed:22846083).
What are the official names of this protein?
Transcription activator AMTR1, AM-toxin biosynthesis regulator 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: ODBA_MACFA
Sequence: MAVAIAAARVWRPNRGLSQAALLLLWRPGARGLARSHPHRQQQQFSSLDDKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRKKVMKAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLEHFDK
What is the function of this protein?
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain, BCKDE1A, BCKDH E1-alpha.
What is the protein family that this protein belongs to?
Belongs to the BCKDHA family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RLMG_STRAW
Sequence: MNDPMTTPWGAYALARFPEDPRDRLRAWDASDAYLLRHLAASGTPLSGSVVVLGDRWGALTTALAAHRPTQITDSFLAREATRENLGRAGVDPSSVRLLTTRDTPPERIDVLLVRVPKSLALLEDQLHRLAPGVHEGTVVVGAGMVKEIHTSTLKLFERILGPTRTSLAEQKARLIFCTPDPGLVRDPNPWPYRYRLPDGVGPLSGRPVTNHAGVFCADRLDIGTRFFLRHLPRVSGAERVVDLGCGNGVVGTAVALTEPEAEVLFVDESYQAVASARETFRANADGTAEFLVGDGLSGVPAASVDVVLNNPPFHSHQATTDATAWRMFTGAKRALRPGGELWVIGNRHLGYHLKLRRLFGNSELVASDAKFVVLRAVKK
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL122_ARATH
Sequence: MPPKLDPSQIVDVYVRVTGGEVGAASSLAPKIGPLGLAPKKIGEDIAKETAKEWKGLRVTVKLTVQNRQAKVTVVPSAAALVIKALKEPERDRKKVKNIKHNGNISFDDVTEIARIMRPRSIAKELSGTVREILGTCVSVGCTVDGKDPKDLQQEIQEGEIEIPEN
What is the function of this protein?
Binds directly to 26S ribosomal RNA.
What are the official names of this protein?
60S ribosomal protein L12-2, ABI1-binding protein 11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RS24_THEGJ
Sequence: MEIKVTEIRENKLLGRKEIYFDIIHEGEPTPSREAVKGKLAAMLDLDPNTMVLQYIRSYFGSHVSKGYAKAYETRERMLYIEPEYILLRDGLIQKEEE
What are the official names of this protein?
30S ribosomal protein S24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: FUT2_MOUSE
Sequence: MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQTLSEKELQAVQMSSPNAARTDMQQSAKLQGIFTINSIGRLGNQMGEYATLFALARMNGRLAFIPESMHNALAPIFRISLPVLHSDTARRIPWQNYHLNDWMEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSNGMAWCRENINTSLGDVVFAGNGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPAAAFLPEWMGIPADLSPLLKH
What is the function of this protein?
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:11018479, PubMed:11368156, PubMed:14967068, PubMed:11323419, PubMed:27161092, PubMed:19706747).  Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (PubMed:11713270, PubMed:14967068).  Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:27161092, PubMed:19706747).  Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:11323419).
What are the official names of this protein?
Galactoside alpha-(1,2)-fucosyltransferase 2, Alpha(1,2)FT 2, Fucosyltransferase 2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II, Secretory blood group protein 2, Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2, Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 11 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Protein: RSCA1_HUMAN
Sequence: MSSLPTSDGFNHPARSSGQSPDVGNPMSLARSVSASVCPIKPSDSDRIEPKAVKALKASAEFQLNSEKKEHLSLQDLSDHASSADHAPTDQSPAMPMQNSSEEITVAGNLEKSAERSTQGLKFHLHTRQEASLSVTSTRMHEPQMFLGEKDWHPENQNLSQVSDPQQHEEPGNEQYEVAQQKASHDQEYLCNIGDLELPEERQQNQHKIVDLEATMKGNGLPQNVDPPSAKKSIPSSECSGCSNSETFMEIDTAQQSLVTLLNSTGRQNANVKNIGALDLTLDNPLMEVETSKCNPSSEILNDSISTQDLQPPETNVEIPGTNKEYGHYSSPSLCGSCQPSVESAEESCPSITAALKELHELLVVSSKPASENTSEEVICQSETIAEGQTSIKDLSERWTQNEHLTQNEQCPQVSFHQAISVSVETEKLTGTSSDTGREAVENVNFRSLGDGLSTDKEGVPKSRESINKNRSVTVTSAKTSNQLHCTLGVEISPKLLAGEEDALNQTSEQTKSLSSNFILVKDLGQGIQNSVTDRPETRENVCPDASRPLLEYEPPTSHPSSSPAILPPLIFPATDIDRILRAGFTLQEALGALHRVGGNADLALLVLLAKNIVVPT
What is the function of this protein?
Mediates transcriptional and post-transcriptional regulation of SLC5A1.  Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1.  Also involved in transcriptional regulation of SLC22A2.  Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.
What are the official names of this protein?
Regulatory solute carrier protein family 1 member 1, Transporter regulator RS1, hRS1.
What are the subcellular locations of this protein?
Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Localizes at the inner side of the plasma membrane.
Protein: RT07_RAT
Sequence: MAAPALRAARRWSGLALGVRCAVWNLPGITQVRWSRYAPEFRDPLIDKEHYRKQVSELTEEEKYDLELKKTQLIKAAAATETSSVFADPVISKFTNMMMKGGNKVLARSLMAQTLEAVKRKQFEKYRAASAEEQATIERNPYKIFHEALRNCEPVIGLVPILKGGHFYQVPVPLADRRRRFLAMKWMITECRENKPRRMLMPEKLSHELLEAFHNRGPVIKRKHNMHKMAEANRALAHYRWW
What are the official names of this protein?
28S ribosomal protein S7, mitochondrial, MRP-S7, S7mt.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ACTB_MOUSE
Sequence: MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity).  Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity).  In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:23558171, PubMed:25759381).  Part of the ACTR1A/ACTB filament around which the dynactin complex is built.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
What are the official names of this protein?
Actin, cytoplasmic 1, Beta-actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: THIC_SPHAL
Sequence: MADIDSRLDTTQATPIGVTTGPIRGSRKIHVASPTGSGIRVAMREILLEPSSGEPPVRVYDTSGPYTDPDATIDIAQGLPELRASWIRARGDVEEVAQREVRPEDNGQLGPDRSGGVPAFPNVRKKVLRAKPGANVSQMHYARRGIITPEMEYVATRENLGRERLAEYVRDGQDWGASIPDYVTPEFVRDEVARGRAIIPSNINHPESEPMAIGRNFLVKINANIGNSAVASDVAAEVDKMVWSIRWGADTVMDLSTGRNIHDTREWILRNSPVPIGTVPIYQALEKVGGIAEELTWEIFRDTLIEQAEQGVDYFTIHAGVRLPYVPLAAKRVTGIVSRGGSIMAKWCLAHHRESFLYDHFDEITEIMKAYDIAYSLGDGLRPGSIADANDEAQFAELYTLGELTRRAWAQDVQVMIEGPGHVPMHKIKENMDKQLEACGEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWYGTAMLCYVTPKEHLGLPDRDDVKVGVVTYKLAAHAADLAKGHPAAQVRDDALSKARFEFRWRDQFNLSLDPDTAEQYHDQTLPAEGAKTAHFCSMCGPKFCSMKISQEVREFAKLQNQDSAGFIAAEEAEKGMAEMSQVYEDTGRELYMGAGGREHD
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: RS4_MYCPN
Sequence: MKYTGSIFKRSRRLGFSLLENNKEFSKGKKRKTIPGQHGNRFRSSTMSGYAQQLQEKQRMQYMYGITDKQFRRLFRLVLKQRGNLAVNLFRVLESRLDNIVYRMGFAPTRRSARQLVNHGHVLLNDRTVDTPSIILNPGDKVRLKAKTIKIPIVKAASESGVVSPFVETNNKTFEGTYVRFPERSELPAGINESYVVEWYKRLVK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: LEUC_ROSCS
Sequence: MPRTLFDKIWDTHIVRPQTAETPAVLYIDLHLIHEVTSPQAFTELRRRGLKVRRPDRTLATMDHSTPTTPRGPDGIIPVVDAQAAAQLRQLEQNCADFGIPLFALGSERQGIVHVIGPEQGLTQPGMTIVCGDSHTSTHGAFGALAFGIGTSEVAHVLATQCLIQNRPKTMEVRVDGRLKPGVTAKDIILAIIARYGVGAGVGHVFEYTGEAIRALSMEERMTICNMSIEGGARAGMIAPDDTTFQYIAGRPFAPKGAAWDEAVAYWRTLPTDDGAVYDRTITLDASQLTPMITYGTNPGMGIPIDGRIPTPEELPDQAARQALDKALRYMDLRPGQPLLGQKVDVVFLGSCTNSRISDLRMAASVLKGRKIAEGVRMMVVPGSQQVKKQAEAEGLDRIFREAGAEWREAGCSACLGMNDDKVPPGKYAVSTSNRNFEGRQGPGARTLLASPLTAVASAIEGVVADPRKYVG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: LEPH_STAAM
Sequence: MKKVVKYLISLILAIIIVLFVQTFVIVGHVIPNNDMSPTLNKGDRVIVNKIKVTFNQLNNGDIITYRRGNEIYTSRIIAKPGQSMAFRQGQLYRDDRPVDASYAKNRKIKDFSLRNFKELDGDIIPPNNFVVLNDHDNNQHDSRQFGLIDKKDIIGNISLRYYPFSKWTIQFKS
What is the function of this protein?
Catalytically inactive.
What are the official names of this protein?
Inactive signal peptidase IA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: ALR_STRPB
Sequence: MISSFHRPTVARVNLQAIKENVASVQKHIPLGVKTYAVVKADAYGHGAVQVSKALLPQVDGYCVSNLDEALQLRQAGIDKEILILGVLLPNELELAVANAITVTIASLDWIALARLEKKECQGLKVHVKVDSGMGRIGLRSSKEVNLLIDSLKELGADVEGIFTHFATADEADDTKFNQQLQFFKKLIAGLEDKPRLVHASNSATSIWHSDTIFNAVRLGIVSYGLNPSGSDLSLPFPLQEALSLESSLVHVKMISAGDTVGYGVTYTAKKSEYVGTVPIGYADGWTRNMQGFSVLVDGQFCEIIGRVSMDQLTIRLSKAYPLGTKVTLIGSNQQKNISTTDIANYRNTINYEVLCLLSDRIPRIY
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: EIF3K_DROAN
Sequence: MSHLVKMENGQSQTIQEMLGCIERYNPDHLKTLEAYVQDQAKNNTYDLEANLAVLKLYQFNPHMLNFDITYTILLKCLTNLPHTDFVMAKCLLLPQQMKDENVQTIIDLADILERADFTLFWQRAEVNRNMFRHITGFHDSIRKFVSHVIGTTFQTIRKDLLKELLGGIEDSTLESWVKRNGWKHQGQGLVVVATQDDKIKTKNITEKIEFENVGALMAQCL
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit K, eIF3k, eIF-3 p25.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit K family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDEP_STAAC
Sequence: MIVNYLKHKFYNLLTTMIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMYDNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHLNYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
What is the function of this protein?
Involved in multidrug efflux.
What are the official names of this protein?
Multidrug resistance efflux pump SepA, Antiseptic resistance protein SepA, Staphylococcal efflux pump A.
What is the protein family that this protein belongs to?
Belongs to the multidrug resistance efflux pump SepA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RBFA_PSEAE
Sequence: MAKDYSRTQRIGDQMQRELAQLIQREIKDPRLGLVTITGVEVSRDVAHAKVFITVMGQDDAGKIALNMEILNDAAGYLRMLLGKSMKLRSVPQLHFHYDESIRRGAELSALIERAVAEDGRRHGDETED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_RICPU
Sequence: MTRAKSGKISKNRHKKILKFAKGYRGRANSCFRVAIEKVEKALQYAYRDRRNRKRDFRGLWIQRINAAVREHGLVYSQFMGALKKTEIDIDRKVLAELAVNNSDGFVSIVEKAKAHI
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.