PharMolix/UniProtQA huggingface dataset:
Protein: RL21_STRP8
Sequence: MSTYAIIKTGGKQVKVEVGQAIYVEKIDAEAGAEVTFNEVVLVGGDKTVVGTPVVEGATVVGTVEKQGKQKKVVTFKYKPKKGSHRKQGHRQPYTKVVINAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RL18_PSEMY
Sequence: MTDKKVTRLRRARKARLKMHELEAVRLCVYRSSQHIYAQVISADGSKVLASASTLDKALRDGATGNVDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRVKALADAAREGGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: HTPX_RHIEC
Sequence: MNLVRTAMLLAFMTALFMFVGFLIGGRGGMMIAFLIAAGMNFFSYWNSDRMVLAAYRAHEIDERNAPEFFAIVRDLARNAGLPMPKVYLYDSPQPNAFATGRNPENAAVAASTGLLQALSPEEVAGVMAHELAHIQNRDTLTMTITATLAGAISMLGNFAFFFGGNRDNNNNPLGFVGVLVAMIVAPLAAMLVQMAISRTREYSADRRGAEICGNPLWLASALGKIARGAAHVPNEDAERNPATAHMFIINPLSGERMDNLFSTHPDTENRIAALQEMAQSGMNVSTGPVRAVNPTRKSRSVPNTGRGGSQPPRGPWS
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GNAL_DROME
Sequence: MSGITLTKLTQERISIPNNNVITNGVENNIDSDTLSGTLTHLMEEHRTRVGAVTGPEAATTSTDGLISNGAERLRLQGSRLQTSRFACFRCCGNIITYLVRLRSTPEELEQRYKSKEIDKFLEKEKHTFRRQVKLLLLGAGESGKSTFLKQMRIIHGVNFDYELLLEYQSVIYQNVIRGMQVLLDAREKLNIAWGSDGREQDAYDAKLMECNSLDVPKFMEYAPPISRLWQDRGIRRAFERRREFQISDSVSYFLDEIQRLATPDYVPTHKDILHCRKATKGVYEFCVKVQNIPFVFVDVGGQRTQRQKWTRCFDSSVTSIIFLVSSSEFDQVLAEDRKTNRLEESKNIFDTIVNNATFKGISIILFLNKTDLLEQKVCNPETDIRWYYPHFNGNPHSVLDVQNFILQMFMSVRRSSSISRIYHHFTTAIDTRNINVVFNSVKDTILQRNLNALMLQ
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit alpha homolog, Protein concertina.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(12) subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERD_STAAC
Sequence: METIIEEYLRFIQIEKGLSSNTIGAYRRDLKKYQDYMTEHHISHIDFIDRQLIQECLGHLIDQGQSAKSIARFISTIRSFHQFAIREKYAAKDPTVLLDSPKYDKKLPDVLNVDEVLALLETPDLNKINGYRDRTMLELLYATGMRVSELIHLELENVNLIMGFVRVFGKGDKERIVPLGDAVIEYLTTYIETIRPQLLKKTVTEVLFLNMHGKPLSRQAIWKMIKQNGVKANIKKTLTPHTLRHSFATHLLENGADLRAVQEMLGHSDISTTQLYTHVSKSQIRKMYNQFHPRA
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCP_THEP1
Sequence: MQMFCYQCSQAANGTGCTEYGVCGKSPTVARLQDNLVFAIKGISAYYYHARELGYDDPEIAGFLDEALYSTLTNVNFDAQSFVEYALEAGRMNLRAMQLLKKAHIETYGEPTPVEVETGTKKGKGIIVTGHNLKALEELLKQVEGTNVYVYTHSEMLPAHGYPGLRKYKNLVGNLGKAWYDQRKLFTEYPVAILGTSNCVLIPSESYRDRMFTTSIARLPGVKHIDGYDYTEVIEKAKSLPDLEEKPGSYKLRTGFSTSVVVSLADKIKELVEAGKIKHFLVVGGCDVPFKRNEYYREFVQKLPKETVVITLACGKFRINDLDLGDIEGIPRLIDVGQCNDTIVAIEIAQALAKVFGVEVTDLPLTLVLTWMEQKAVAILWTLLALGLKNIYVGPVLPAWVNEDILKVLTAEFGLKTISEPEKDIKEILKV
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QTRT2_DROYA
Sequence: MKFAIESISKNSGRLGQLRIKDGGPDFKTPLLLQTTKGGSIPWLSADVFESHVSQKPQVLQFTLSTMDHMTEALTHWNSGGGRGLSDYVGLPGHLNILMLRDPCETTPSGGNDRDILPLFTRRGKESLSSERYMEMVASFKPDFYEGLCDADTNLESAKKRIQKSVDRTEKFMHYIYEHRGKVNSTLLAPIVGGYNTFARTQSIKHAREQPAGSYGGYIFEGFHTNGLSATTLDTSKLLPIVEHCVKQLEEDKPRLMPGAYTPLTILELIRQGIDMFDSSYAYCASLNFKALTFSFVQDAVEHAPFLDITDEAIKEDFTPPLSNCSCLTCQKHTRAYLHHLYKTNELLGPILLIVHNLHHYMAFFEKIRESVARDELPRLTEFVRNQNGKTQVDYSIAANTKVISKAAMGKGFAAAAV
What is the function of this protein?
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase accessory subunit 2, Queuine tRNA-ribosyltransferase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP2_AHSV6
Sequence: MASEFGILICDKLKENTLEKTNCDVIITGVGKVGVHEEDGVLGYEWEETNYRLGLCEIENTMSISDFVYKQIRCEGAYPILPHYVTDVIKYGMVIHRNDHQIRVDRDEKSIGKIQIQPYFGDMYFSPEYYPATFIKRESLPISVDTIRGYIGARMRGIEARAGRIREGDGNLLECARRWEKAAYERIENEKALRCVAHETDPTYQILKKQRFGFVYPHYYVLNTNYNPTTVTRTSRINDWLLKEKTQGVVKTAEAFSDNAELKTLAERMEEEELTEDIIRAVIRYGAKYATRSGMREDTLSLQELDRYCDSLTTFVHKKKKDEGDDETARTIIRNQWIKGMPRMDFKKEMKITRGPIANWSFFMSIDAFKRNNKVDINPNHQTWKDHIKEVTDQMNRAQQGNNNKPLKVQIDGVSILTSEKYGTVGHWVDWVVDLIMLAQVKMLIKEYKFKRLNSQNLMSGMNKLVGALRCYAYCLILALYDYYGQDIEGFKKGSNSSAILETVIQMFPNFKQEIQANFGINLNIKDKKTIAIRRATMHSDFSSNEEYGYKFVFGWAARGEEVLSNYGDVLSDEVEELFTKLRKKEHWDKVVEDPESYFIDELYQKNPAEVFYSAGYDTDQNVVIDGKMTEGVTYFSKRFVSYWYRVEKITTKHLEFLTEENRKVAQFDFEDYKPMAIGEMGIHASTYKYESLLLGKNRGQKVNDSIALCNYDLALTNFGVSRRQDCCWISSCSAIELSMRANIIIAIFRRIEDKRYENFAKILSGLTQQQDLYFPTYKHYYLFVLQKVLRDERRIDLNRICTELFDTQRRRGILLSFTALRFWNDSEFLGDALMMNFLHRVVFEMENVDVDYGKKWHPLLVSSEKGLRVIAVDVFNSMMGVSTSGWLPYVERICSESDMRRRLNADELELKRWFFDYYATLPLERRGEPRLSFKYEGLTTWIGSNCGGVRDYVVQLLPMRKSKPGLLCIAYGDDVNVQWVEHELRDFLMHEGSLGLVVISGKMLVNKSKLRVRNLKIYNRGTLDSLFLISGGNYTFGNKFLLSKLMAKAE
What is the function of this protein?
The VP2 protein is one of the two proteins (with VP5) which constitute the virus particle outer capsid.  It is the major target of the host immunogenic response.
What are the official names of this protein?
Outer capsid protein VP2.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP2 family.
What are the subcellular locations of this protein?
Virion.
Protein: DLGD_CITK8
Sequence: MKVTFEQLKEAFNRVLLARGVAAETADACAEMFARTTESGVYSHGVNRFPRFIQQLDNGDIIPDARPQRITSLGAIEQWDAQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGSKECRIGTNPLIVAIPSSPITMIDMSMSMFSYGMLEVNRLAGRELPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLLSDGASVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFVTTAERADENVAIRLPGHEFTRLRDENRRNGITVDDSVWAKIQAL
What is the function of this protein?
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
What are the official names of this protein?
2,3-diketo-L-gulonate reductase, 2,3-DKG reductase, 3-dehydro-L-gulonate 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_SALPB
Sequence: MERITVTLGERSYPITIAAGLFNEPASFLPLKSGDQVMLVTNETLAPLYLDKVRGVLERAGVNVDSVILPDGEQYKSLTVLDTVFTALLKKPHGRDTTLVALGGGVIGDLTGFAAASYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPASVVVDLDCLKTLPARELASGLAEVIKYGIILDADFFTWLEGNLDALLRLDGPAMAYCIRRCCELKAEVVAADEREAGLRALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGIVMAARASERLGQFSSADTQRIIALLERAGLPVNGPCEMSAQDYLPHMLRDKKVLAGELRLVLPLAIGKSEVRGGVSHEVVLSAIADCQQA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XYL2_YEAST
Sequence: MTDLTTQEAIVLERPGKITLTNVSIPKISDPNEVIIQIKATGICGSDIHYYTHGRIANYVVESPMVLGHESSGIVALIGENVKTLKVGDRVALEPGIPDRFSPEMKEGRYNLDPNLKFAATPPFDGTLTKYYKTMKDFVYKLPDDVSFEEGALIEPLSVAIHANKLAKIKFGARCVVFGAGPIGLLAGKVASVFGAADVVFVDLLENKLETARQFGATHIVNSGDLPHGVTVDSVIKKAIGKKGADVVFECSGAEPCVRAGIEVCKAGGTIVQVGMGQEEIQFPISIIPTKELTFQGCFRYCQGDYSDSIELVSSRKLSLKPFITHRYSFKDAVEAFEETSHHPLNNIKTIIEGPE
What are the official names of this protein?
D-xylulose reductase, Xylitol dehydrogenase, XDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: ATPE_RHIE6
Sequence: MADNFNFELVSPERLLLSEMVTEVVIPATEGEMTVMAHHAPTMTTIKPGIVSVRSGSGKKQDYVVFGGFADILPTGCTLLAESAVPVEELNKDELTRRIEAAKKELEDAVHHEHKSKLEHFILELTHLRGVVQQD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AROC_DEHMC
Sequence: MSNSLGKLFQITSFGESHGDCVGVVIDGVPAGLAINVDEIQIEVDKRKSGAKAHTTPRREDDRIEIFSGIFNNFTTGAPICLVIWNKNIDSSEYERTRSKIRPGHADFTGFMKYGGFNDYRGGGRFSGRITAGHVMAGAIARKLISTIGIEVIGYTAELGGITAKLPKHKDIRQNISQSDVNCPDLAASKQMVALIQQAAEEGDSLGGVVECIGLNLPVGLGEPVFDTLEGELAKAIFAIPAVKGVEFGAGFGASRLRGSKNNDPFNIQSDQIRTTSNNCGGILGGISDGMPLHVRVAVKPTPSISLSQPTVNLDTMTNTSLEIRGRHDTCIVPRAVSVVEAMTCIVLADLALRAGIIPRVIKQ
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: DAPB_MARSD
Sequence: MTDVVIIGAKGRMGDTLVRCVQQSDDLKLAAVMERSGCEEGLDSLGCVCGTDAQEVLTKVPGAVVVDFTSPAATLKLLEIASVTGNPVVIGTTGMTNEELAQVEEFAKKVPVFLAPNMSVGVNVLLKVLPELVRMLGDAYDMEMTEIHHNKKVDSPSGTALKLAQCMAEARGLVYDEVKKHSRDGIIGARTKDELGVMAVRGGDVVGDHTAYFLGPGERIEVTHRAHSRETFAQGALRAARWLSEQKPGKLYDMADVLDV
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_STRZT
Sequence: MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAEDYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDKEEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNKLGGDDFDQKIIDHLVAEFKKENGIDLSTDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMTLTRAKFDDLTRDLVERTKVPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNEVDQAIFATEKTIKETEGKGFDAERDAAQAALDDLKKAQEDNNLDDMKAKLEALNEKAQGLAVKLYEQAAAAQQAQEGAEGAQATGNAGDDVVDGEFTEK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: NDHK_PROM2
Sequence: MNPQLSPKAIREIREGTCNPLGAPQVTTDLSENIILTSLDDLHNWARLSSLWPLLYGTACCFIEFAALIGSRFDFDRFGLVPRSSPRQADLLIVAGTVTMKMAPALVRLYEQMPEPKYVIAMGACTITGGMFSADSTTAVRGVDKLIPVDLYLPGCPPRPEAIFDAVIKLRKKVGNESILERKKTEQTHRYITSDHEMNLVFSENTGEYLNKTSAKVISSSQKEKITELPEKTEITNTEKD
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, NAD(P)H dehydrogenase I subunit K, NDH-1 subunit K, NDH-K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL33_PROMS
Sequence: MAKKGTRVVVTLECTEARTSTDPKRSNGVSRYTTEKNRRNTTERLELKKFNPHLNRMTIHKEIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: CUTC_ECOLU
Sequence: MALLEICCYSMECALTAQQNGADRVELCAAPKEGGLTPSLGVLKSVRQRVTIPVHPIIRPRGGDFCYSDGEFAAILEDVRTVRELGFPGLVTGVLDVDGNVDMPRMEKIMAAAGPLAVTFHRAFDMCANPLNTLNNLAEFGVARVLTSGQKSDALQGLSKIMELIAHGDAPIIMAGAGVRAENLHHFLDAGVLEVHSSAGAWQASPMRYRNQGLSMSSDAHADEYSRYVVDGAAVAEMKGIIERHQAK
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_METFK
Sequence: MVKEFSRSDRVAEQIQRELADLLQFEVKDPRVSSMVTVTEVEVSGDMSHAKVYYTAPQGTPELQKGLEKTAGFLRSQLARRLLLRTVPQLHFVYDASIDRGMRIAKLIDEALPPVADPDQDSEPN
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLO_STRT2
Sequence: MDKLIKTISESGSFRAYALDSTETVRTAQEKHNTLSSSTVALGRTLIANQILAANQKGDSKITVKVIGNGSFGHIISVADTKGHVKGYIQNPGVDIKKTATGEVLVGPFMGHGQFVSIIDYGTGNPYTSSTPLISGEIGEDFAYYLTESEQTPSAVGLNVLLDKEDKVKVAGGFMLQVLPGASEEEIARYEKRIQEMPAISTLLESDDHIEALLNAIYGDEPFKRLSEEELSFECDCSRERFENALLTLGKDELQAMKDEDHGAEIVCQFCQTKYEFSEADLEELIND
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_CHLSY
Sequence: MSAERLVNPHSDSDDQQVEKSLRPRTLSEFIGQEKVVEQLRIAIAAARGRNESLDHTLFYGPPGLGKTSLANVVANEMGAKIKITSGPAIERAGDLAAILTNLQANDVLFIDEVHRLNRAVEEVLYPAMEDFALDLVVGKGPGARSLRLNLPRFTVIGATTRLALLTSPLRDRFVAVHRLVFYSDDAMTEIVSRSARILGVPISPEGAREIGRRARGTPRIANRILRRVRDYAQVVADGAITLQVARDALAQLEIDELGLDENDRRLLRAIIELFNGGPVGLSTLAAALAEEVDAIEDVYEPFLLQLGFLQRTPRGRIATRRAYEHLGLPYPERTLPADDESGPQQATLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: BEA4_GIBF5
Sequence: MTDESKRCRTKKVKARTGCSTCKRRKVKCDEQLPGCKRCAKIGVECPGYHKPVKWSVKYERHLVNSSPTAGNSFSCFDSGAGNLSNLMQPKSNPGSVETQNHNDNEVQAPGPLTRGSSSSLSDAREHLEDTLEMQPPSTLNSEQLSTLCDDVQADEEFPCALNALHDDSLCLTSYIPTLQTSLILDHYFTTVCHFNSSFDSANNPFRSEVSRMMADSPLLFGCVLSMSAAHLYQGDKSSSCIPLEFQTEAMSHLSRTLSELPTRNECEVDDNRPMALVSREKILNVSDDLLLSIIFLGMTAAWHDVSATGLPHLHGSRQLFRSWISLNNLTDIEKRRKMTRTQIFVVSSMVYWEAMSSALFDQQYEGLSHLTMFCDPHPPALVQPCPWTGVATPIFVFLAKTLTLVRNNQALKSLWVFESGEIHRRALYGELLAKANSLEREILRYRLPSLALIEDIGDPCTTPDHLLAISRCYRMAALLELYSAFPEITRTGGRPDSAIDLDRGDEKTHLIMGLAFSILEILEKIPDDSGTISIQLLSLLIAGSVLGPVPPRGEDEGPKRLETLRLRTFVRQRIHKMYAAVRLGPIGNAMAILEEVWARMDMLPAIQNANSAISSFHWINIMSQKKLETMFG
What is the function of this protein?
Transcription factor that specifically represses the expression of the gene cluster involved in the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity (PubMed:27750383).
What are the official names of this protein?
Beauvericin cluster-specific repressor BEA4, Beauvericin biosynthesis cluster protein 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: YIDD_SHESH
Sequence: MAKTQSPLQWLATTLIRGYQVFISPFLGANKCRFHPTCSTYAIEAIRLHGFAKGSWLAARRILKCHPLHPGGIDPVPPKKHRCNK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HACL1_MOUSE
Sequence: MPESNSAEGSDRSEEQVSGAKVIAQALKTQDVEYMFGVVGIPVTEIALAAQELGIKYIGMRNEQAACYAASAVGYLTGRPGVCLVVSGPGLIHALGGMANANMNCWPLIVIGGSSERNQEAMGAFQEFPQVEACRLYTKFSARPSTIELIPFIIEKAVRSSIYGRPGACYIDIPADFVTLQANVTSIKYKECCMPPPVSMAETSAVCAAASVLRDAKQPLLIIGKGAAYSHAEDSIRKLVEQCSLPFLPTPMGKGVVPDNHPNCVGAARSRALQSADVIVLFGARLNWILHFGLPPRYQADVKFIQIDICAEELGNNVRPSVILLGDIDAVSKQLLEQFDKTPWQCPPDSQWWKTLREKMKSNEAISKELASQKSLPMNYYTVFYHVQEQLPRDSFIVSEGANTMDIGRTMLQNCLPRHRLDAGSFGTMGVGLGFAIAAALVAKDRSPGQRVICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDADTWEKMLHFQEAATTVPPMCLLPNSHYEQVMTAFGGKGYFVRTPEELQHSLRQALQDTSKPCLLNIMIEPQSTRKAQDFHWLTRSNM
What is the function of this protein?
Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (By similarity).  Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (By similarity).  Plays a significant role in the biosynthesis of heptadecanal in the liver (PubMed:29027957).
What are the official names of this protein?
2-hydroxyacyl-CoA lyase 1, 2-hydroxyphytanoyl-CoA lyase, 2-HPCL, Phytanoyl-CoA 2-hydroxylase 2.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: DDH2_SCHPO
Sequence: MRVVLFSSQSYDRGPFEEANKTFNHEIIYHNFSLNKDTVSLAGKAQVVCVFVNDQVDADTLKALAENGVKLVALRCGGYNNVNLKAASEYKITVVHVPSYSPFAVSEFTVGLLLSLNRKIHRAYVRVREDDFNIVGLLGCDIHGKTVGVIGTGKIGSNVAKCFKMGFGCDVLAYDINPDKKLENYGVQFVEQNEVLKKADFLCLHCPLTPSTTHIVNSDSLALMKKGVTIVNTSRGGLIDTKALVDAIDSGQVGGCAIDVYEGERNLFYKDLSNEVIKDSTFQRLVNFPNVLVTSHQAFFTTEALCSIAHTTLKSASDFYTNSLDESVIANK
What are the official names of this protein?
2-hydroxyacid dehydrogenase homolog 2.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: S246B_XENLA
Sequence: MQPRRPDRFDGLEYRGTSWGRGDGDVPPYQSSFPARSLSSSGDLSQQWVTSPPDIPGSRNLHWGEKSPQYGADSNAGPPAFGEENSGSSGEQVNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQNYQLSPFSIVNIMYNFTKTQGPRALWKGMGSTFIVQGISLGAEGMLSEFTHLPRELSHKWNLKQLGGHLLLKGLVYVIVTPFYSASLIETVQSEIIHDNPGILDCLKEGIGRVLNLGVPYSKRLLPLLVLTFPTVLHGILHYIISSTIQKCVLFFIKKRSPPQLPAEGSNAVQNKLEDYFPELLANFAASLCADVLLYPLETVMHRLHIQGTRTIIDNTDLGHEVVPINTQYEGLKDCINTIKREEGGLGFYKGFGAVVVQYTLHAIVLQITKIIYSSVVQTAR
What is the function of this protein?
May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.
What are the official names of this protein?
Solute carrier family 25 member 46-B.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: DCUP_THEAC
Sequence: MDPFRKAIKGYDHDRIPVWFMRQAGRYLPSYMKYRQRMGIEEMMSSPDVIVDVTHDPVDRIGVDAAIIFADITTPLSGMGLRVRFLDSVGPVVENNIEKSGISAVEEFDPSSFSHPVLKAISKYRERYADPLIGFAGGPVTLLSYIISDGVDRDLFRVKRMMITEEKAYQAVMTRLTDMIIEFARMQISAGVDAFQIFDSWAGYLSPGEYEHFVKPYVYDILQELSGSIPTIYFSTMTSSYVADMDLPADFYSIDWRIDMKRFSAEIPDEKGIQGNLDPAIVNYDYALHEASKIVEAASGRDRYIFNTGHGLLPSTDPEKLKRLVEYVHSVNL
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.