Protein: RIF1_CHICK
Sequence: MSGTVSAAAGLRPLLETLQDPAAPAGDLTDAHLSLVNRLSGEEGREFVAAVRKHFPRLCKVFKAHISSENSELSNAALQALGFCVFNSKITSELSASEVEDLLSTLNSIAVKTSDKNTRTRALWVISKQTFPSEIIKKEVSSLISTLETILTKGDVQSMIVEYEALNVVIRLMEQAPAQMGEEAVRWAKLIIPLVVHSAHKVQLRGATALEIGMPLLLQKQQEVAAVTEHLMTTKLISELQKLFSTKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELGFRSGSPVVKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTEALALTKLEVWWYLLMRLGPQLPANFEQVCIPLIQSTLSVDSAAALQGTPSRVPSNPNSANPPQKPGPYPFASPATPRMNLNSSTAGLVAIPSIQLLGIEMLLHFLMGPEVLEFAKRNKLVLSLEPLQHPLISSPSFFCKHASTFINAVQDGFIAVGKEVPESMLNSIWKDINGHVKAAIESGNKKEKQGSEVLTMLLQALKNIVRSNSLPVQKILSLIDITVKELPPKVLGSPAYQIADMDLLNGTPALFLVQLPFHNNLLEWCVTDERFFIILETLMRYVLSGPTSLLAFSESVLCVINQNAKQVENKEHLWRMWSIVVNPLTDWINRTNEVNQGDALEHNFNAVYNALLLPVSHIFPVQEFPQPTMKSLLRAWSDLYRAFARCAALVATAEENLCCEELCAKIISGLEGETPVMSAMLDGLTHVVAVMVDCINFAPYGTKYQPKNRSPQTPTDWSKKKREPLGKLSSLFKLLVMLLDSFHALSSEETCPEPLASVGHSLIAVLHNIISHVSLPSMIGTMFAVFSKPLAVFYEKTKLADVPKAYSNLNSKLEKLLAEIILCLQSHCMGCYDSELLEQLSPLLCVIFQHKSKQMRKQCANFWNTTFAKAASLTYPEELKPVLSQAKQKMPLLLPGFESIEIADEQSGPFSDEAENSQWDAKLSGMEVNLGQKRDSILAQTGELKNEVKDKSDNVQVTSAKLKLEFSASKPKSDVLLEEEKSVDFVFIPPETKARILTEHQKEVLRSKRVGIPAMYNNLDSSQDTTLFSQYTQSQEDSLEKSPLENAKEDFKNNPQEENGKSESCIADSDGNTGDCKVDNPLEDVKEKSAYHIEKNSNSEEESSRGDRTGIIGEESSVGEALEKSGTETASKESLVGNENTSAISCSSTSSDVICGTPQPASRRQSFITLEKFDSSESRPFSPSALNSVSEVSQSAPVPDKQGNINVCKTGRKPGKSGEESRKSSQSEQISAAKRRLTRRQSKMEQQGNQQAKLVTNSEQEKGAQESFVSNSVENSPESPCSMEDTERVLTAQPQPVSSPEPDIKKAEAVMAEIEKVRAFEMDSKENTPPKTAVSSEQVMGDGSQGPHASLSQKTLRRSSRRRSENAEMAAGSQDKEDGYQKKDKRKEDEKALQKKVPQTKEDASQKQKAVCGKASEHAIKKESSLPERSAAEDLGSKEPPAAKGADEEANRSAGKPEDTLKSDSEGQDCSSDTVSEKKRERPRYHTRRSSQGLLSSIENAEADGSETKKESLKKKSGKTKNKSDSLEGKRKDVQPESQSHGVSSQVDESKNLSGMNESELSSEVSTDAALMSAPSDVKNQVLLAGADEAEGSASSRTSPSTQNVSVEQSKAGVLPESFSDPRVSDEVLKGDENKCIEKQSSVEQHSSVQPENVQGANTSGSDLSSLQMQDCQHKRSKRVRKAKSCDCCSKRVKQQTSLSESKSEDPRELIEPQATPVQMAVSTAEVSGSSNLEESLSITPCAMSTPLPPAKESGMLSLERERTGEDNLQGNSGVMKEEAENPAHTAGEVSDPVVEIKVKEEVDGNDRAEQCVSVSECASDEPSDSSVAAGDQSEEKAAVEKEEESQHGEMEEVPEADGSKPETKQMDELEGNRDGKEEAENALEEVCITPDNEMREELLEAEITVPENVAVGNKDVVVENKSADSPQKPEGLDSFTSVNGSPSGVQARCTWSPSASPSTSILKRGVKRHHEDDSLSPANKIRRVSFANPIYQEGLADDIDRRSPVIRSHSSPSSRSLKILSNIQTKHITTPTKGFLSPGSRNPKFKSSKKCLMTEMVKESLPSPTECVYPALAGCKAPVDVILPQITSNICARGLGQLIRAKNIKTVGDLSALTASEIKTLPIRSPKVSNVKKALRGYHEQQVKSRGCEEIGALEDGERTVNSAEDKSPPVDEEKLATDLGEAIALSSSSPPPADLLSQMDLLAAQLTSEDLRSYPGSRLFEMQEKLASMSDCIMKTLRSRWRSPPHDSAE
What is the function of this protein?
Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:23333306).  In response to DNA damage, interacts with ATM-phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity).  Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306).  In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).
What are the official names of this protein?
Telomere-associated protein RIF1, Rap1-interacting factor 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RIF1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Note=Following interaction with TP53BP1, recruited to sites of DNA damage, such as double-strand DNA breaks (DSBs).