PharMolix/UniProtQA huggingface dataset:
Protein: ATG4_PICAN
Sequence: MASHSLNTLHTVFEYIWDRELPNDDFTNTLTVLGRTYAPGPPPHQEKAPDLRTLFHKFKPDQAADTEASWPREFLRDVHSRIWLTYRSGFPLIKRAEDGPSPLSFGSLIRGTVDLATVTKGFTTDAGWGCMIRTSQSLLANSLLQLRLGRGWRYDQTRECAKHAEIVSWFVDIPTAPFSIHNFVEQGANCAGKKPGEWFGPSAAARSIQVLCEANYDKTGLKVYFTASGDIYEDELFELAQQGAELRPVLILAGIRLGVKNVNPLYWDFLKKTLGWPQSVGIAGGRPSSSHYFFGFQGDYLFYLDPHVPQKALLIASEAPHESPDPNHYVEVESGLDLDSVHTNKIRKLHLDQMDPSMLVGLLVENRASYDALKHSINSHDQGSRFLNVYDSRPVLAAKSSGGLEESEFVDLGVLSMNEYDAIDDCDVGTCSALLRKERAFSHPVLVAMDPEEPEEIDASIHFDKDASILEKDPDRANETFEEIHVSETESRFEPDEPVVVSHDSAAVM
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8 (PubMed:17204848).  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS (By similarity).
What are the official names of this protein?
Probable cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: CY231_POSPM
Sequence: MDVSTNELAILAIVLLATGVLFYAKGTRRAPLPPGPRGIPFFGNLFQVDAMRPYPQYLKWAQKYGPVVSIKLGGQHVIVLNSSEAADELLVTRSKQYSSRESPHVAFDLVSDQQQMLFMPYGREWKIVRKNVHGLLGPGSSKQMRKMQDLESRVILHDLLCHGETSISEDFVEGPHGEVPERHWFSIIRRYTTSLMMTLMYGHRIHRIVDNPELHQVYAVVSNFTHVSQPGRYLVDVFPVLRRLPDIMAPWRAEGKKMHEWEMGFWGKLFSDSRTALLDGSGLDGFVQSYLRSRAEAGCEDLPGKGVTEDAAGWMRDKLVTYTASGIIEAGSDTTSTAMFSFVLLMLSNPDALQRAKEEMDAVVGSSRMPGWEDEDRLPWLKACIKETLRRAPPLPLGVPHKTEEDDVYNGRLIPKGSTVIGNIWAIHMDPIRYPNPTSFKPERFYHPDEKLDWASGPDTHDRDHYIFGWGRRFCSGKHIAEASLFIVLSRLIWGFDLYTGSDAKTGQARLPDVNDEATFTDGLVAAPKIYPVGFKPRSEKHAEMIKASYRDVQNDWQSMGLAGDER
What is the function of this protein?
Cytochrome P450 monooxygenase that is able to use anthracene, carbazole, pyrene, and phenanthrene as substrates for oxidation (PubMed:21938516).  These multifunctional properties against a series of polycyclic aromatic hydrocarbons (PAHs) suggest that CYP231 would play important roles, at least in part, in fungal metabolic systems involved in xenobiotic detoxification (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase 231.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CR3L2_PONAB
Sequence: MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSTEVEPSPMSPAPLIQAEHSYSLCEEPRAQSPFTHITTSDSFNDDEVESEKWYLSTDFPSTTIKTEPITDEPPPGLVPSVTLTITAISTPFEKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEEPSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTTF
What is the function of this protein?
Transcription factor involved in unfolded protein response (UPR).  In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane.  In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2.  The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes.  Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity).  In a neuroblastoma cell line, protects cells from ER stress-induced death.  In vitro activates transcription of target genes via direct binding to the CRE site (By similarity).
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3-like protein 2, cAMP-responsive element-binding protein 3-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element- binding protein 3-like protein 1) is transported into the nucleus. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Note=Upon ER stress, translocated into the nucleus.
Protein: Y1253_KLEP7
Sequence: MSDVNAHLLAQRIDTVLDILVAGDYHSAIHNLEILKAELLALAADDAEQQNQPKAPWEI
What are the official names of this protein?
UPF0509 protein KPN78578_12530.
What is the protein family that this protein belongs to?
Belongs to the UPF0509 family.
Protein: RUVA_ACIBY
Sequence: MIGCLIGEVFALEAPTVLLNVNGVGYEIDTPLSTFCQLQKGQKVTLWTHLVVREDAQQLYGFSDAQEKTIFRTLLKVNGVGPKMALGILSTLSVELLVHTIEHDDVNTLVKVPGVGKKTAERLMIELRDRFKTLAQGTSSAAALPQIQFVSNSPVAEAEAALQSLGYKPLEAQKAVAAVKADYTESADIIRAALKSMMK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ISPE_CLOAB
Sequence: MNVKAYAKVNISLDVIGKREDGYHLLKMIMQSINLYDVLDIRIIDEGIKITSNRRNIPTNDKNIAYRAAKLFMDTYKIDKGISIHINKRIPVAAGLAGGSADGAAVLKAMRDIFKKDVSDEELINLGVKIGADIPFCIVGGTAFCEGIGEKITKLRSMNGKIIVLVKPDFGVSTKMVYTEYDKCLDVKHPDSEGLVKAVNNGHFKFVVNNMVNVLENVTAVKYKEINEIKEKALEYNSIGTMMSGSGPTVFSFFDNTKEAEKYFYEMKKEYNKVFITRTV
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: NSP4_ROTB2
Sequence: MEGTSESPILDEFEANSNDYDNEFISRFSQNPLHAFSLFTNGNIQEYFMNNSLEKIIIHIVLIIISLCGIKAQTSKIIYIVRLLFWKMYNVINNLVNKMINREKIADRQIVDNRFREFEERFRILLLQHDENIAKQDNIVQYNKLDNFAESIKSEFNLKVAEMERRFQELKWRCDMIANKTMNTIVLTNTVDSTNKDEKIIFDEGSVVQYNRE
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: ADDB_LISMF
Sequence: MTLQIIAGRSGTGKTTYLMDEVSVKIKQNSKTYIFIVPDQMTFQMETSFLNKENLEGMLGTQIFSFSRLAWKILQETGGLSKTFLSQTGIEMVIRKAALDQRDKLKIFSRATSRKGFYAELANLFKEMKQEEVSIEDMVKSATNLSTSVNNKIHDISIIYQKYEELLADKFLENEDYLRLLAEKITESDYLNQTEIVIDGFTSFSQQELTVIGALMRKCDKVTVSLALNVPEIKHGLDEYSMFKASTEAYYALLELAKLNSINVEEDKFFLENKRAKTESLAFLANAWGHNKFMAFKEEPHNLSVHQANNRRAEIEGVAREIRQLTLNGYRYQDMAILTRNLGDYDVLCETVMESYNIPIFIDKKRAMSKHPFIEFIRSSLDAILFNWKYEPIFQAVKTEFFFGVAEKSSVLRRKADILENYVLENGIQNKWKWEKEGDWIYRKIRGLSTNVLPQTDGEIQTQSIINEMRSLIVNPLSTLELNLKKAKTGMEFALALYHFLEQVNAVERLESWRQRAEEQGYLELAREHEQAWSAISALLDEFVEVLGKETLDLNSFVEIIATGLDALEFSLLPPSLDQVVLSDMENAKLLDMKVIFAIGMNDGVMPLRQKDNGILSDQDRDALRAEVSNLKPSAKNNIGEEDLLAYKIISLPSDKLFLSYPAADEEGKVLSESNYLRKIKGQFKKLSESVYLTDPGLLSDAEQSSYIRSKQATLGLLTSQLQMYKRGYPLSSVWWDAYNSYFENGKESRMAKQVLSSLYYENKTKPLQEKTAKNLFGETIHASVSRMEKFFSCEFQHFAQYGLKLEERGHFQLQAVDMGEIFHGAMEWISAELKRNNLDWGSLTDQECRQMAKLAMTFLAPKIQHEILLSSKRMEYIQYKLLQIITRATTVLNEQAKSSAFRPVGLEVDFGLKGDIPPLKISLQANSELLLQGRIDRIDMAEQEDRTFLRIIDYKSSSHDLALTEVYYGLALQMLTYLDIVVTNAQKMIGKTAEPAGVLYFHMHNQYVQAEKELSDEAIVKELQKNSKMKGLILSDPVAVSLMDTTLEKGKSSNIVPAEIKQNGELSARSKTATREEFDKMRHFVRHKYQEAGNKILDGAVSINPYKLKERTPCQFCGFRSFCGFDPSLASNQYRHLTNEKTETILAKMNIEGGEQ
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB, DNA 3'-5' helicase AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.
Protein: CH10_PROMT
Sequence: MAAVSLSVSTVKPLGDRVFVKVSESEEKTAGGILLPDTAKEKPQVGEVAQVGPGKRNEDGSRQSPEVSVGDKVLYSKYAGTDIKLGSDEYVLLSEKDILAVVN
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COFE_HALLT
Sequence: MELFAVPGLPEIRDGDDLAAMIDERVDLREGDVVVVASTVVSKAEGRTFDLSDFPASERAEAVADRLAEIAGEEKDPRFAQAVIEESTELIMEAPFLLTATRFGHIGVNAGIDQSNVPDGDLLLLPERPSESAARIREGIAADRVVVSDTCGRPFRHGQRGVAIGWAGLPASRDWRGERDRDGREMGVTVQNVIDELASAANLVAGEGDGGTPVVVVRDWEFGDHDGSDNHFREVEGDFVRQALRQWTFDD
What is the function of this protein?
Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
What are the official names of this protein?
Coenzyme F420:L-glutamate ligase, Coenzyme F420-0:L-glutamate ligase, Coenzyme F420-1:gamma-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the CofE family.
Protein: MATK_SOLTU
Sequence: MEEIHRYLQPDSSQQHNFLYPLIFQEYIYALAQDHGLNRNRSILLENSGYNNKLSFLIVKRLITRMYQQNHFIISTNDSNKNPFLGCNKSLYSQMISEGFACIVEIPFSIRLISSLSSFEGKKIFKSHNLRSIHSTFPFLEDNFAHLNYVLDILIPYPVHLEILVQTLRYWVKDASSLHLLRFFLHEYCNLNSLITSKKPGYSFSKKNQRFFFFLYNSYVYECESTFVFLRNQSSHLRSTSFGALLERIYFYGKIERLVEVFAKDFQVTLWLFKDPFMHYVRYEGKSILASKGTFPLMNKWKFYLVNFWQCHFSMYFHTGRIHINQLSNHSRDFMGYLSSVRLNHSMVRSQMLENSFLINNPIKKFETLVPIIPLIGSLAKAHFCTVLGHPISKPVWSDLSDSDIIDRFGRICRNLFHYYSGSSKKKTLYRIKYILRLSCARTLARKHKSTVRTFLKRSGSELLEEFLTSEEQVLSLTFPRASSSLWGVYRSRIWYLDIFCINDLANYQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL6_DEIGD
Sequence: MSRIGRQPIAVPNGVTVNAQNGVFTAKGPKGELSVPYNTALNITQENGQLLVTRPSDRQEHRALHGLTRTLVANAVKGVSDGYTINLELRGVGYRARLVGKNLELTIGYSHPVVIEPPAGVTFAVPEPTRIDVMGIDKQLVGQVAANVRKVRKPDAYHGKGVRFVGEQIALKAGKAGATGGKGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NTPP_CAMJD
Sequence: MLILASSSISRANLLKTAKIDFKQVGFDYDENLDKNISPFLYVQKIVLEKEKQFLSALSKDFQNQNLLFADSIVCIDEKILTKAKDKKEAYEMLALQNGKYASILSAFLLVKPEKRVFSLSKTTLYFKNFDENALNDYVENNLYKSKAGCIMCEGFHQNFITQQVGNLSTALGLDIQTLKAYL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_SOLUE
Sequence: MTHTKSEELFRRAVEKIPGGVNSPVRAFRSVGGQPVFIARGQGSHLFDVDGNEYIDYVGSWGPLILGHRHPEILAALERALEIGTSFGAPTEQEIDLADAIIDAVPSVEMVRLVNSGTEATMSAIRVARGFTGRDLVVKFEGCYHGHVDSLLVKAGSGMATLGIADTQGVPKAFADTTIPLPYNSLDALEEAFRAHGDRIAAVIVEPVVGNMGCVPPLPGYLEGMRAITERYGALLIFDEVMTGFRVAFGGAQQLYGIKPDLTTLGKVIGGGLPVGAYGGRKDIMSKVAPAGPIYQAGTLSGNPLAVAAGLAMLRHLKRNPQVYTRLEECGARLAAAAPKGVTVNRVGSMFTFFFTDGPVTDWESAKRCDTSRFGEFFRGMLDRGVYLAPSQFEAAFVGAAHSDEDIAKTIEAAKTA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_VESOH
Sequence: MAVQKSRKTPSKRGMRRSHNALVKSTLSEDQETGEIHLRHHITTDGFYHGKKIINKVQNIQKINA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RIMP_CLOP1
Sequence: MKKEQLVADLEALCAPIVKEKGYDLYHIEYVKENNEYYLRLYIEKPEERISLRDCEIVSRALSDMLDIEDPIKDAYFLEVSSPGLNRRLHSDEHFNRFIGKEVFVGFKSSLSGRKNVKGILKDVQENEIIVECEGNEIKVPKDKIKTANLEGEI
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_ROSDO
Sequence: MKDMDSVSAMMSQIGQRAKEAAASLGFASVERKHAALISAAEHIWTQRAAILEANAKDIAYGRDKGLSDAMMDRLLLDEERLRGIVTSLRSVAEQADPVGEVIAAWDQPTGLHIERVRTPLGVIGVIYESRPNVTVDAGALCLKAGNAVILRGGSESFHSSKALHACLVQGLRDANLPEAAIQLVPTRDRAAVSEMLTMTDTIDVIVPRGGKGLVGLVQREARVPVFAHLEGIVHIYIDAAADAEKTLKVVMNAKTRRTGICGAAECLLIHKDVMPTLGADVIKELMRAGVEVRGDETLSAIQGVVKATADDWGREYLDMIVAARVVDDIDDAMAHIRTHGSNHTDCILTEDARAARRFMTELDSAIVMHNASTQFADGGEFGMGAEIGIATGKMHARGPVGAAQLTSFKYLVSGDGTTRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENOF1_XENLA
Sequence: MITGKITCLHITDVRFPTSLDQHGSDAMHTDPDYSAAYVVIETDAADGLKGHGLTFTLGKGTEVVVCAVRALSRHVIGKALEDIVNNFRDFYRQLTSDGQLRWIGPEKGAVQLATAAVLNAVWDLWAKKEKKPLWKLLVDMDPHQLVSCIDFRYITDALTEEEALKILQNGKQGQRDREEHMLTSGYPAYTTSCAWLGYSDEQLKKLCSDALKEGWTRFKVKVGADLKDDIRRCELIRDMIGPDNIMMLDANQRWDVQEAISWVKDLAKYKPLWIEEPTSPDDILGHATISKELSPVNIGVATGEQCHNRVMFKQFLQAKALQYLQIDSCRLGSVNENLSVLLMAKKFNVPVCPHAGGVGLCELVQHLILFDYICVSGSLDNRMCEYVDHLHEHFTYPVIINRAAYMPPKDPGYSTEMKEESVLQYQFPDGAVWKKLILEKKVEV
What is the function of this protein?
Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins.  Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion.  May down-regulate thymidylate synthase activity, possibly already at the RNA level, by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism.
What are the official names of this protein?
Mitochondrial enolase superfamily member 1, L-fuconate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FIBA_EQUAS
Sequence: TKTEEGEFISEGGGVR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1559_YERPG
Sequence: MNINVANLLNGNYILLLFVVLALGLCLGKLRLGSIQLGNAIGVLVVSLLLGQQHFAINTEALNLGFMLFIFCVGVEAGPNFFSIFFRDGKNYLMLALVMVGSAMILALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHTMANGSSLQQAQDNLSLGYALTYLIGLVSLILGARYLPKLQHQDLPTSAQQIARERGLDTDSQRKVYLPVIRAYRVGPELVAWADGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQVGDEISLVGYPDAHSRLDPSFRNGKEVFDRDLLDMRIVTEEIVVKNSNAVGKRLSHLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKSVAEKIGFISIHSQVTDLLAFCSFFILGLMIGLITFQFSNFSFGIGNAAGLLLAGIMLGFLRANHPTFGYIPQGALNMVKEFGLMVFMAGVGLSAGGGINSSLGAVGGQMLISGLIVSLVPVVICFVFGAYVLRMNRALLFGAIMGARTCAPAMDIISDTARSNIPALGYAGTYAIANVLLTLAGSLIVILWPGILG
What are the official names of this protein?
Putative transport protein YpAngola_A1559.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MSD2_AMAPH
Sequence: MSDINATRLPIILAPIIPCINDDVNSTLTSGER
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:24613547).
What are the official names of this protein?
MSDIN-like toxin proprotein 2.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: F16PA_CAMJR
Sequence: MQEVISYIQKAVLEISNALKFPDTSYSQNQNFTGDTQLKFDVLSDEIITKTLSQCSSIKAIISEEKDEILTLNERANFIVAYDPLDGSSLMDVNFAIGSIFAIYEEKANAKNLRAALYSMYGARLELVICKDQPKLYRLNANNEFIFIKDLKMNEKGKINATGGTQKFWEEKHAKFIKNLFDEGYRLRYSGAMVSDINQILLKGGGIFSYPATQDAPNGKLRAFFEVFPLAFIIEKAGGKTTNGKNRSLLELEFDKIHATTPCFFGSEYEISKLLKAYNE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_MYCTU
Sequence: MRPALSDYQHVASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKGRVLTAMSAFFFGLVDAPNHLAGPPDDPRIPDEVLGRALVVRRLEMLPVECVARGYLTGSGLLDYQATGKVCGIALPPGLVEASRFATPLFTPATKAALGDHDENISFDRVVEMVGALRANQLRDRTLQTYVQAADHALTRGIIIADTKFEFGIDRHGNLLLADEIFTPDSSRYWPADDYRAGVVQTSFDKQFVRSWLTGSESGWDRGSDRPPPPLPEHIVEATRARYINAYERISELKFDDWIGPGA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: ATPA_BACAC
Sequence: MSIRAEEISALIKQQIENYQSEIEVSDVGTVIQVGDGIARAHGLDNVMAGELVEFSNGVMGLAQNLEENNVGIIILGPYTEIREGDEVRRTGRIMQVPVGKELIGRVVNPLGQPVDGLGPINTTNTRPIESPAPGVMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTAVALDTIINQKDEDMICIYVAIGQKESTVRNVVETLRKHGALEYTIVVTASASQPAPLLYLAPYAGVTMGEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFIETQAGDVSAYIPTNVISITDGQIFLQSDLFFSGVRPAIDAGTSVSRVGGSAQIKAMSKVSGTLRLDLASYRELEAFAQFGSDLDKATQAKLNRGARTVEVLKQGLHKPLRVEKQVIILYALTRGFLDDIPVVDITRFEEEFHAWLDSNATDLLEEIRTTKKLADDDKFAAAINGFKKVFVASE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.