PharMolix/UniProtQA huggingface dataset:
Protein: MDM12_AJEDR
Sequence: MSIDIDWERATSGPDGELLAERIRSFIHDKFQQIVLPRFIRSVQVTSFNFGTIPPELEIRDLCDPFPDFYEEDDNENFSESSEEQSPTREPVDRYGSKVESWQANSPGSLEDHMQGRMGFNGPLRMPPGEENTGISPLRSPMNFGDINPYLFPRSRTPGIPGGTSNLGYYMPLSGLSGSQTPLGTVARGSPFSGGWPDVHGARPSRRRSEVEPDSAQSRPSTANTGNTLLSRGSMSSGDPRHSHHSQGVPGSDHGQVLEPNMPPTSSDPPLDDLPPRRMREQKAEDFQVFCRTKYAGNISLSLTAEILLDYPMPSFVGLPLKLNITGLTFDAVAVIAYIRRRIHFCFLSPEDADALIGPEIGSGGGEDTLEPNSPRRKPLSLLREIRVESEIGRKENGKQALKNVGKVEKFVLEQVRRIFEEEFVYPSFWTFLV
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: TSAD_MYCSJ
Sequence: MIILAIESSCDETGVGIAELSEDGTVTLLADEVASSVDEHARFGGVVPEIASRAHLEALGPTMRRALDTAGVGRPDVVAATIGPGLAGALLVGVAAAKAYSAAWQVPFYGVNHLGGHLAADVYDHGPLPESVGLLVSGGHTHLLHVRSLGEPIIELGSTVDDAAGEAYDKVARLLGLGYPGGKVLDDLARQGDREAIVFPRGMTGPRDDPFAFSFSGLKTAVARYVESHPEASQADVAAGFQEAVADVLTRKAVRAAETLGVSTLLIAGGVAANSRLRELAEQRCAEAGLTLRIPRPRLCTDNGAMIASFAAHLIAAGAPPSPLEAASDPGLPVVRSQVA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_RHOOB
Sequence: MDHAEQGPDRPGVDDPGRGRRIGIDVGSVRIGVASSDPDGILATPVETVPRSKDRGPDAPDIRRIADIVEEYEAVEVIVGLPQTLRGERGKAASIATVFAKRLRRKVDPIPVRMADERLTTVTAARALRESGVSARGQRPVIDQAAAVAILQGWLDERSRSVNAGDVGGDVQLPEAGQ
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_PARMW
Sequence: MSRIGKNPVPVPDKVTVSLDGLTVKVKGPKGELERTLPDGVSVSQDNNCIVVAPSTSKRFSRERHGLCRTLVANMIEGVNNGYSKSLEIVGVGSRAQVKGKTLVVSAGYSHPVEMEPPEGITFKVENNTKVIVSGIDKELVGNEAAKVRAIRPPEPYKGKGIKYEGERIMRKAGKSGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ATPB_ANGLY
Sequence: MKTNPLVFVVSTAVEKNAGYITQIIGPVLDVAFSPGKLPNIYNSLIVKGQNPAGQEINVTCEVQQLLGNDRVRAVAMSATDGLMRGMKVIDTGAPLSVPVGEVTLGRIFNVLGEPVDNLGPVDAGTTSPIHKSAPAFTQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESKVINQENISESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQDVLLFIDNIFRFVQAGSEVSASSGRMPSAVGYQPTLATEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHSDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPWIVGEEHYETAQGVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVSLIETIKGFQMILSGELDSLPEQAFYLVGNIDEATAKAATLQVES
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: PUR7_SALA4
Sequence: MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLAEAGIPTQMERLLSDTECLVKKLEMVPVECVVRNRAAGSLVKRLGVEEGMELNPPIFDLFLKNDALHDPMVNSSYCETFGWVSQENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRLWDKETLDKMDKDRFRQSLGGLIEAYEAVAHRLGVKLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CBP4_LODEL
Sequence: MAEKPLWYRWARVYFAGGCLVGLGVVLYKTIRPTDEELISRFSPEIRAEYERNKELRQKEQQRLMEIVKKTSASTDPIWKTGPIGSPLEKDQRNLSMQLVDQELFHKTKEEEKQKAEINKSVEEGKEVERLLRENKNQKSWWKFW
What is the function of this protein?
Essential for the assembly of ubiquinol-cytochrome c reductase.  It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity).
What are the official names of this protein?
Assembly factor CBP4, Cytochrome b mRNA-processing protein 4.
What is the protein family that this protein belongs to?
Belongs to the CBP4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: NUOK_SALPC
Sequence: MIPLTHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SURE_NITHX
Sequence: MRILCTNDDGINAPGLEIIEQIAKDLSDDVWVVAPEYDQSGVSHSLSLNDPLRLREIGPRHFAVKGTPTDCVIMGSRHILGEKGPDLVLSGVNRGRNLAEDVVYSGTIAGALEGTMLGLPSFALSQEFSMETGDRPVWETARKFGPQILRKVIDVGIPKNTVVNINFPACAPEQVVGVLVTRMGKRNLGFLKIDERRDGRGNPYFWIGFEKADVVDTPAAGTDLAAIAARCVSVTPLRLDRTDDAFVEVLTATLK
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METAA_STRT1
Sequence: MPIKLDNKLPALDVLRSENVFIMDENRASSQDIRPMEVLILNLMPTKEVTETQLLRLLANTPLQINVEFLYMASHKSKNTHAEHMETFYKTFDEIKDKYYDGLIVTGAPVEQMPFEEVDYWQELTRVFDWSKKHVYSTLHLCWGAQAGLYYKHGVDKFPLSEKLSGIYKQTVDMPENFLMNGFDDSFVSPHSRYTEVTLEDIKNKTDLDVVASGQEVGLSILASKDLREVYSFGHFEYDRDTLAREYRRDLEVGINPDVPANYFPGDDPSQEPKLRWNLAASTFFSNWINYAVYQETPYRLEELEDDFSFYGYL
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCPB_OCEIH
Sequence: MNMNEFKGVIEGLLFASGDEGVTAKQLSKILDIGLDTVEHILEELRFEYEREDRGLMIIQSNNIFHLATKPEHSSYFKRLIDSPRTSKMSQAALETLAIIAYRQPITRAEIDEIRGVRSERPVQTLITRNLIEETGRKDTVGRPVLFQTSKEFLTFFGLATLDDLPPLPENIDPDKEEREADLFFERFQDEV
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: EXGA_ASPFC
Sequence: MIFKFSQKALVALYLVVGLAEAVPSKSRVVSRASTFDYNGIVRGVNIGGWLVLEPWITPSIFDNAGDAAVDEWTLTATLGQDQAKAVLSQHWSTFITQDDFQQIAQAGMNHVRIPIGYWAVSSLPDEPYVDGQLEYLDNAISWAREAGLKVVIDLHGAPGSQNGFDNSGRKGPIAWQQGDTVSQTVDAFRALAERYLPQSDVVTAIEALNEPNIPGGVSEAGLRDYYNQIADVVRQIDPDTSVFLSDGFLSTESWNGFKTGEDVVMDTHHYEMFDNYLISLDIDGHVKSACDFGKQIEGSDKPVVVGEWSGAVTDCTKHLNGKGVSTRYQGEYANNVKYGDCANTTQGSVADLSDQERTDTRRFIEAQLDAYEGKNGWLFWTWKTEGAPGWDMQDLLANGVFPSPLTDRQFPNQCA
What is the function of this protein?
Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall.  It could also function biosynthetically as a transglycosylase (By similarity).
What are the official names of this protein?
Probable glucan 1,3-beta-glucosidase A, Exo-1,3-beta-glucanase 1, Exo-1,3-beta-glucanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRC_SYNS9
Sequence: MSDQIQLIAPDDWHVHLRDGEMLKQVVPYTAQMFRRAIVMPNLRPPVVTVEAAKAYRDQIVAACHPNWGFTPLMTAYLTDDIAPEEIERGFHEGVFTAAKLYPANATTNSAAGVTELRHIHGVLLVMERIGMPLLIHGEVTDVDVDVFDREAVFIERSLKPIRDRYPGLKVVLEHITTEQAVDFVGSADQNLAATITPHHLHINRNAMFAGGLRSDFYCLPVAKRERHRLALRRAAMSGDRRFFLGTDSAPHARPGKESSCGCAGIFNAPHALESYAMAFAQDDKLDKLEAFASLHGPAFYGLPVNEGIVTLQRDDKLVPNVVNGLVPFHAGETLPWRLQPCT
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: EXOT_RHIME
Sequence: MTPTVNAKTVTRNVGWSVLSKTGTFGLKFVTVPILARILSPEEFGAVAVALTVVQFLAMIGGAGLTSALVIQQHEEMETVHSVFWANLAIALMMALGLFVFAEPLATLLGAPEAAYLLRIMSLLIPLQLGGDVAYSLLVRRMNFRKDAVWSMISESLGAVIAVLLALLGFGIWSLLAQLFVSALVRLSGLYAVSRYAPRFVFSLQRVLALSRFSFGMMGSEIANFITFQSPMVVISRYLGLSDAGAYSAANRFASIPNQVVLSAVMGVLFPTFGQMMHDRERRSQALMLSTQVTTVLLAPMMFGLWALAEPAMLVLFGSQWAYAWPVLGLLALSKGILTPCSTFIPYLKGVGQGAVLFWWALIRAVATTGAVAYGAIDGSLVEAMIWLCIVNAVTLVGYSWVVFRADSTPFLKGLFISSRPMIAALLMALVVRFLLEHFGAHVPNAVLQLIAGTAIGSVIYTVLILLTERSLLRRLLDMARARKPRAAPAGAAE
What are the official names of this protein?
Succinoglycan biosynthesis transport protein ExoT.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GUAA_MARMS
Sequence: MSQDIHAHKILILDFGSQYTQLIARRVREIGVYCEVRAFDMEDQDVIDFDPKGIILAGGPESVPEPGSPRAPEAVFTLGVPVFGICYGMQTMAEQLGGKVQGSEIREFGYAQIRKHEGPALFDDIQDHIANNGVALLDVWMSHGDKVITMPEDFTLMASTDSCPIAAMANEAKKFYGVQFHPEVTHTLQGGRILSRFIVDICGCDTLWTPANIAQDAIERMQEQVGDKKVLLALSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMKMFADNMGVKVIRVDAEDLFLGKLANEADPEKKRKIIGNTFIDVFDTEATKLTDVEFLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPEDMQFKLVEPLRELFKDEVRKLGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEYADILRRADAIFIEELRNAGWYEKTSQAFAVFLPVKSVGVVGDGRRYEYVVALRAVETIDFMTARWAHLPYELLEKVSGRIINEIEHISRVTYDVSSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: CA11_CONST
Sequence: MGMRMMFTVFLLVVLAITVVSFPLDRESDGANAEARTHDHEKHALDRNGCCRNPACESHRCG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
What are the official names of this protein?
Alpha-conotoxin-like S1.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: IL1A_CAVPO
Sequence: FEDLKNCYSENEEYASAIDHLSLNQKSFYDTNYDPLHENRVDEPVSPNPYENSEESNFTLEDSSDSSAVVLTSAHGEVLKKRRLSLNQTMSNEDLEAIANDSEEEIIEPWSVPYSFQSNLKFKYQRSIKKGAVITDAMHQSLIRESNGQHLKAMHVVDRKHEVKFDIDGYVSTATRIRPVTLKISKTQLYVCAQEEGQPVLLKE
What is the function of this protein?
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.  IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).
What are the official names of this protein?
Interleukin-1 alpha, IL-1 alpha.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: PIMT_PYRFU
Sequence: MMDEKELYEKWMRTVEMLKAEGIIRSKEVERAFLKYPRYLFVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGSGWNAALISEIVKTDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIPEPLIEQLKIGGKLIIPVGSYHLWQELLEVRKTKDGIKIKNHGGVAFVPLIGEYGWKE
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins (By similarity).
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_RICRS
Sequence: MINVEIVRHYNKWREHKQINKSLIKKITQNILLRFDNFSKIKQFELSILLTNAAEILILNKQFRNIEKATNVLSFPSNELNWQDLYSKLEFLGDSDYMHLGDIAFCYEVIYNESCEQYKTFENHFIHLLIHSILHLIGFDHQNDTEANIMENLEIEILSYFGIFPPY
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_SHEFN
Sequence: MIDTIMLDAQERMSKCVDATKNQMAKVRTGRAHPSLLDSIQVSCYGSMSPLKQVANVGVEDSRTLTVNVFDRSMVQAVEKAIMSSDLGLNPMSAGATLRIPLPSLTEERRKDFIKVVRNEAENGRIAIRNVRRDAISEVKKLEKAKACTEDDVRRSEDEVQKHTDSSIKNIDQILAAKEKELMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_SALSV
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQVAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLEGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMAERFNMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLNVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLEDLADLDVLSTDDLKNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPS16_CAEEL
Sequence: MGESHAPSKPKLDGELCLRPSSSVFLGDQQLYFTQEYLRTNSLNLKYVVYFTACQFSGPIAVAYSPRPASWYIWIRTISGRILKRDMAFNEPVFMEWTRAHCLLVLNKAGRAHIFSSLGEKISEVIFDSQMSDVHECRTFATSRGDSGIAVMDVDGQVSVVNSVSEPVIWSMKPPYSEMPTAWTAFQPHSQLTHILLIFEAVFLMGCQGESLREQSHAASWVDSNTKYVKCVVDDARSRIAMMTESGKIQIVSIDLSTCFCTVEITDHDIAKCINFGWVGNSAVFVQMSPSLIVFVNVSARRKPGDEVQIYEKMTANAKISIEPDGIRLFESTQVEFVEAASREKIAVLNRNPNEDGAHLYKAAQEMSQGTGHNSFAASTVIQDLYKAIDDCISTACDTWQPEEQKLLLKAARFGMAYTNTTPDTTKLMRAIKEIRVLNELRMVRTGIPLTHRQFRAIGETCVINRLIDMGSYSVAIKVAQWLGGETSENVDRVLLEWVRRSISKVSKSNMKMDQPALEALDEKISAKLLQFPHVSIADAARRAIEAKLPELARLFIRRETDDANHVAVLLQLNDVSAALQKASASQRPQLIHQVVRHLMNSESRSSYELAISRIPLAQCLYQDLVRQEGETRGASSRQMLALLEQASDFERQTLFHFDVAETERNPDERLNALRRAKDAAKSMGDKAIEEILNDVSAFAPLQIQRGQADMSVRDTVIEMAHDTAKVAQLKQQARLTDKQVLLWTIEGLAKKGKMEQLFDLAQKRSPIGYAPFVKACVRYKRLDEIKKYFAKVNGYPDLVAAHLAMKNYVEAAKLAYDRRDRDVLHAVHMKSHEDPTQCPRVGQFLRSLDQN
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301).  Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity).  The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity).  Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine (PubMed:15843430, PubMed:24501423, PubMed:25273556).  The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity).  Required for recruitment of vps-33. 1 to the HOPS complex (By similarity).  Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with vps-33. 1 but not vps-33. 2 (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 16 homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS16 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Protein: SYL_DELAS
Sequence: MQEKYNHIDVERAAQDHWSARDAYRVTEDQAKPKFYACSMLPYPSGKLHMGHVRNYTINDMLTRQLRMKGYNVLMPMGWDAFGLPAENAALKNKVPPAQWTYDNIAYMKKQMQAMGLAIDWSREIATCDPDYYKWNQWLFLKMLEKGIAYRKTQVVNWDPVDQTVLANEQVIDGRGWRTGAPVEKREIPGYYLKITDYAQELLDHVQVGGDKATLTGWPEKVRLMQENWIGKSSGVRFAFTHDIRGADGQPIQDGRLYVFTTRADTIMGVTFCAVAPEHPLALHAAATSPKLAAFIEECKKGGTTEAELAVKEKEGLPTGLFVTHPLTGAQVEVWVGNYVLMSYGDGAVMGVPAHDERDFAFAKKYGIAIRQVIAVEGETFSTEAWADWYGDKQRAVCIESGELDGLPHAAAVDKVAELLAAKGLGEKKTTWRLRDWGVSRQRYWGTPIPIIHCEDCGAQPVPAKDLPVVLPQDLVPDGSGNPLIKSEAFHAGVVCPCCGKSARRETDTMDTFVDSSWYFMRYCDARNSEQMVAEGAEYWMRDQNAATGGSGMDQYIGGIEHAILHLLYARFWTKVMRDLGLVKVDEPFTKLLTQGMVLNHIYSRRTAKGAKEYFWPKDVEHVFDETGKIVGAKLKAEVDSADGLLPVGTDIDYEGVGTMSKSKNNGIDPQELIEKYGADTARLYTMFTAPPELTLEWNDAAVEGSYRFLRRVYNFGAKLSQMDMAGAVQSVAGAKSLDDVEFGKAAKSLRLEIHTVLKQVEYDYQRMQYNTVVSGAMKMINALEDFKSFDDAGAQVALIEGFGILLRVLYPATPHLAHALWSELGYAAHLGDVLDAPWPQVDPQALVQDEISLVLQVNGKLRGAILVSSTADKAEIERIALANEECQKFTNGAVPKKVIVVPGRLVNVVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECX_ACIF5
Sequence: MTTERSDPTALALRLLARREYGRRELGDKLLRAGCDAGDVALALDALAAAGYQDDARYVEMLTRTRVRQGHGPLRLRQDLQRAGIEVGADPEIDWLQQAQAVCRKRFGNTPPADARDYARRARFLAGRGFTGETIRQVLGAGRERDFAAD
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_MYCPN
Sequence: MAFRLAVDCLGFENHPREAIDAVLEYWSYHQELEFILVGDEKTFDGLDYLPKNITKQLASSCIDMTDTPLTARRKVNNSMQKAINLVRDGAADVVISAGSSAVYASLTYDGFGKIHKDVKSAFMSYVPTANNDWFYFLDVGANKNFTGKELYFLGLMADIFVKKTTNKISPRIALLNIGTEIHKGFDYHQEGYQLLNEDKHLNFTGFIEPRFLLDGVCDILVADGYSGNLVLKSMEGTFKTIARLLKQGYKRNPLAGLFSLGILKRIAKRFDYKNNAGAVVIGLNKLALKTHGSADKQQFLSTIRLAHTSLKSDLINAIKSSLDNYEK
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: GCSH_RUTMC
Sequence: MSEIRDDRQYTQTHEWILDHGDGTYTMGITDHAQALLGDMVFVELPNIDDEVSIEDEFCVVESVKAASGVYAPADLQIIKVNKALDDEPELINYSCYDDGWLVKFKSHSVDDLMNVAVYAQILD
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.