PharMolix/UniProtQA huggingface dataset:
Protein: PAPS1_CAVPO
Sequence: MELPGSLCKKAKLGHGAQSWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALGEHLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDACDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAESLPALQINKVDMQWVQVLAEGWATPLGGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATEEDKERLDGCTAFALIYEGRRVAILRNPEFFEHRKEERCARQWGTTCKSHPYIKMVMEQGDWLIGGDLQVLDRIYWNDGLDQYRLTPTELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHRQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGILNPESTVVAIFPSPMMYAGPTGVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYKPTHGAKVLTMAPGLITLEIVPFRVAAYNKRKKRMDYYDAEHHEDFEFISGTRMRRLAREGQKPPEGFMAPTAWAVLAEYYKALEKA
What is the function of this protein?
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway.  The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase).  In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway.  Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells.
What are the official names of this protein?
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, PAPS synthase 1, PAPSS 1, Sulfurylase kinase 1, SK 1, SK1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the sulfate adenylyltransferase family.
Protein: ISPH2_MYCBO
Sequence: MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETVRFGLPKQVRAQ
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2, HMBPP reductase 2.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: PPOX_SCHPO
Sequence: MSIAICGGGIAGLSTAFYLARLIPKCTIDLYEKGPRLGGWLQSVKIPCADSPTGTVLFEQGPRTLRPAGVAGLANLDLISKLGIEDKLLRISSNSPSAKNRYIYYPDRLNEIPSSILGSIKSIMQPALRPMPLAMMLEPFRKSKRDSTDESVGSFMRRRFGKNVTDRVMSAMINGIYAGDLNDLSMHSSMFGFLAKIEKKYGNITLGLIRALLAREILSPAEKALKAALLAEPKTAELSNSMKSTSMFAFKEGIETITLSIADELKKMPNVKIHLNKPAKTLVPHKTQSLVDVNGQAYEYVVFANSSRNLENLISCPKMETPTSSVYVVNVYYKDPNVLPIRGFGLLIPSCTPNNPNHVLGIVFDSEQNNPENGSKVTVMMGGSAYTKNTSLIPTNPEEAVNNALKALQHTLKISSKPTLTNATLQQNCIPQYRVGHQDNLNSLKSWIEKNMGGRILLTGSWYNGVSIGDCIMNGHSTARKLASLMNSSS
What is the function of this protein?
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
What are the official names of this protein?
Protoporphyrinogen oxidase, PPO.
What is the protein family that this protein belongs to?
Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y877_RICCN
Sequence: MDQRKSGGIPLHAVAKNVRCTSKDIKDYEIYKLLVSYGADINARVEFTGVGFSIYDGKTISEIVEFKIAFVGESEVITEE
What are the official names of this protein?
Putative ankyrin repeat protein RC0877.
Protein: NEMA1_LINLC
Sequence: YRIASSSIAKMKTAVFLVGLLFLGLVFADEAAIDSEFDQSIDKRGCIATGSFCTLSKGCCTKNCGWNFKCNPPNQK
What is the function of this protein?
Highly potent toxin against insect sodium channel (Nav) and with less potent activity against mammalian sodium channels (PubMed:29567943).  Potently inhibits inactivation of insect sodium channels of B. germanica (BgNav1) (EC(50)=8. 6 nM), D. melanogaster (DmNav1), and arachnid sodium channel V. destructor (VdNav1) (PubMed:29567943, PubMed:34445875).  Also delays the inactivation of most mammalian Nav channels tested (hNav1. 1/SCN1A; EC(50)=124. 1 nM, rNav1. 2/SCN2A; EC(50)=359. 6 nM, rNav1. 3/SCN3A; EC(50)=135. 4 nM, rNav1. 4/SCN4A; EC(50)=145. 5 nM, hNav1. 5/SCN5A; EC(50)=138. 3 nM, mNav1. 6/SCN8A; EC(50)=240. 4 nM, hNav1. 9/SCN9A; EC(50)=76. 5 nM) (PubMed:29567943, PubMed:34445875).  1 uM is enough to completely inhibits the inactivation, resulting in sustained non-inactivating currents (PubMed:29567943).  In addition, the toxin significantly enhances the recovery from inactivation, and the open state is not required for the toxin to interact with the channel (PubMed:29567943).  In vivo, injection into green crabs (Carcinus maenas at 1 mug/kg) of small doses (1-5 ug/kg) results in slow and fast permanent paralysis, whereas injection of high doses (more than 10 ug/kg) causes death (PubMed:29567943).  Injection into juvenile Blaptica dubia cockroaches results in death or permanent paralysis at doses higher than 7. 1 ug/kg (PubMed:29567943).  Injection into brine shrimp (Artemia salina) stops movement or causes death after 24 hours (EC(50)=0. 3 uM) (PubMed:34445875).  In the rare inherited cardiac arrhythmia Brugada syndrome 1 (BRGDA1), this toxin is able to restore the loss of function by reducing channel inactivation, without affecting activation, by binding to Nav1. 5/SCN5A (PubMed:32850980).
What are the official names of this protein?
Nemertide alpha-1.
What is the protein family that this protein belongs to?
Belongs to the nemertide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMA_STRA3
Sequence: MRIADKTVTRAILERHGFTFKKSFGQNFLTDTNILQKIVDTAEIDKGVNVIEIGPGIGALTEFLAENAAEVMAFEIDDRLIPILADTLARFDNVQVVNQDILKADLQTQIQAFKNPDLPIKVVANLPYYITTPILMHLIEGKIPFAEFVVMMQREVADRISAMPNTKAYGSLSIAVQYYMTAKVSFIVPRTVFVPAPNVDSAILKMVRRDQPVVSVQDEDFFFRVSKVAFVHRRKTLWNNLTSHFGKSEDTKAKLEKALEIAKIKPSIRGEALSIPDFASLADALKEVGI
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_HELPY
Sequence: MQDFKTHLEPLKEGKNLLGFSGGLDSTCLFFLLVGENIVFDIALVDYNTQKQRLEIIQHAQKLAKTHHKKCYIHHAPKIAHNFEMQARKIRYDFFETLIKEHSYKHLILAHHLNDRLEWFLMQLSKGAGLNTLLSFQAYEKRESYAIVRPLLYTPKDTLKTLAKDLKFFEDDSNSSLKFKRNCFRKNYANSLMQDYSKGIIQSFKFLDQEKERLYPLTIVSQMHGITFFKYSQNALFMVDKILKQKGYVLSFSQKEEIKRSFFSLEIAQKFIIESDKEHVFIALKPPKTLSMPKDFKDRARRLDIPKRLRPVLYAEFLKQPTHDFLTRFKQSLMDL
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_DIOEL
Sequence: MPIGVPKVPFRSPGEEDAVWVDVNRLHRERLLFLGQEVDNEVSNQLVGLMVYLSIEDATKDLYLFINSPGGWVIPGMAIYDTMQFVSPDVHTICMGLAASMGSLILVGGEITKRLAFPHARVMIHQPASSFYEAQAGEFILEAEELLKLRETLTKVYVQRTGNPLWAVSEDMERDAFMSATEAQAHGIVDLVAVENENTNDFV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: TO1B_HADVE
Sequence: SSTCIPSGQPCPYNENCCSQSCTYKENENGNTVKRCD
What is the function of this protein?
Inhibits insect, but not mammalian, voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-hexatoxin-Hv1b, Omega-HXTX-Hv1b, Omega-atracotoxin-Hv1b, Omega-AcTx-Hv1b.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 08 (Shiva) family. 01 (omega toxin) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXD_SYNAS
Sequence: MKKSINEIADFLGGKVVGDGGILIKAVRGIDEAGPGDITFVANPQYEKKLNETGASAVLVTRDTERPGENVTLIQVDDPYVSLGKLLTIFYPEEREKPGISAQAIVEEGAEISPSATVYPGVYISSGAGIGAGVVLYPGVFVGRDAVIGENSILYPNVCVYRRCLIGKRVILHAGAVVGSDGFGFANPGRDNIKIPQIGIVQIDDDVEIGANTTIDRATLGRTWIQRGVKIDNLVQIAHNVVIGEKSIIVSQVGISGSTRLGRSVILGGQAGLVGHLQIGDFAMVGAQSGVHEDVPANSVVSGSPCQPHRNWLRSMSCLPRLPDMRHLLNDLRKRIETLEKLSEMKKEVEKEKESSREKEETK
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: AVT1G_ARATH
Sequence: MELEEQERDILFPTDDEECQVDVSCDDEDDDSSSYSSLSQNDSAPWPRSYRQSVDILTGVTPPTISFIHRRSSQTSFTSSVASLYKRRPTSIANSFASSTSKQPLLSEKDDVLFLSSQIGLSNTDLSYGEPNFCSFPQSVLNGINVLCGISLLTMPYAVKEGGWLGLCILLSFAIITCYTGILLKRCLESSSDLRTYPDIGQAAFGFTGRLIISILLYMELYVCCVEYIIMMSDNLSRVFPNITLNIVGVSLDSPQIFAISATLIVLPTVWLKDLSLLSYLSAGGVFVSILLALCLFWVGSVDGVGFHTGGKSLDLANLPVAIGIFGFGFSGHAVLPSIYSSMKEPSKFPLVLLISFGFCVFFYIVVAICGYSMFGEAIQSQFTLNMPQQYTASKIAVWTAVVVPMTKYALALTPIVLGLEELMLPSEKMRSYGVSIFIKTILVLSTLVVALTFPFFAIMGALMGSFLAMLVDFIFPCLCYLSILKGRLSKTQIGICVFIIISGIVSGCCGTYSAIGRLVGKLD
What are the official names of this protein?
Amino acid transporter AVT1G, AtAvt1G.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.5) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GVPA_MYCSS
Sequence: MSTAIQPAGTAGGGGSDSNGLADVVDTILDKGLVLDAYVRVSVVGIEILTVDARVVVASVDTYLRYADAVNRLDIVNEDPKSDLGGLVGDVAESATSGVAKGKTTGVLEAAGEKLGDMLTSDEPEPRKATRVRSRRADR
What is the function of this protein?
Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms.  They allow the positioning of the organism at the favorable depth for growth.  GvpA type proteins form the essential core of the structure.
What are the official names of this protein?
Gas vesicle structural protein, GVP.
What is the protein family that this protein belongs to?
Belongs to the gas vesicle protein type A family.
What are the subcellular locations of this protein?
Vacuole, gas vesicle membrane.
Protein: EIF3J_YEAST
Sequence: MSWDDEAINGSMGNDDAVLMDSWDAEIGDDEPVMQSWDAEEEEKKPAPKPKKEQPKKVKKGKESSADRALLDIDTLDEKTRKELIKKAEMESDLNNAADLFAGLGVAEEHPRARALQKEQEEQALKRPAFTKDTPIETHPLFNAETKREYQDLRKALTAAITPMNKKSPLNYSSSLAIDLIRDVAKPMSIESIRQTVATLNVLIKDKEREERQARLARVRGGTATGGAGKKKVKGKTNLGGAFKKDQDFDLDGPDDFEFGDDDFM
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit J, eIF3j, Eukaryotic translation initiation factor 3 30 kDa subunit, eIF-3 30 kDa, High-copy suppressor of Rpg1 protein 1.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit J family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGB_BIFLO
Sequence: MPVAQGDLDATSNAEFYNPHGVLGGHLGIGKHADTATIRVLRPLAKSVTILTQDGEYPMTHEYNGVFVVTVPASGTKKQPTIPDYRVRTEWESGAVLIEDDPYRYMPTVGDMDTYLFGEGRHEKLWETLGAHVLRYDDPMGGADGTPGEQVVGTAFSVWAPNAHAVRVVGNFNAWDGRRHAMRELGSSGVWEIFIPGIGAGETYKFQILNANYTWEMKADPMERQHEVPPSTASIVTESTYKWNDDAWMQHRRTTNPHDGPVSIYEVHAGSWKQGLTYRDLAKQLVDYVKQEGFTHVEFMPLAQHPFSGSWGYQVTGYYAVDSRLGSPDDFRYLVDQFHQAGIGVIMDWVPAHFPKDAFALGRFDGTPLYEDPDPLRGEHPEWGTYVFNFGRREVRNFLVANALFWLEDLHVDALRVDAVSSMLYLDYSREPGHWRPNIYGGRENLEAIDFLKEATATAYKNNPGVMVIAEESTAWPGITAPTSAGGIGFGMKWNMGWMHDTLEYLHEEPINRKWHHNEITFSMVYAYSEHYVLPISHDEVVYGKGSLYGKMPGDDWQKLAGVRSMFAYQWAHPGKKLSFMGNELAQWGEWDHDASIDWDCLNWQEHRQVQTMVADLNAFYKAHPALWSQDFDPAGFQWLTSDDADHNTLSFLRIGTKGETLAVVVNFSGEAWSDYQVALPTGGKWTEVFTTDDAKYGGSDIHNGTFEAVEGEYHSRPFSAKITVPALGVVFLKPED
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: YAC1_SCHPO
Sequence: MDYPSKDVEFVTTGMFIIDEIEFDGGKKIKDIIGGAGSFALIGARLWTSEPESQQLGMIVDKGSDFPQVILDELNDLHTGIVYRETPWRKTTYGYNRLRDNGFRLFEYLTPKKPIRAPDLLETGLIYAKTIHIITNPKTFVSVCEELAKYGNLKNRPKIVWEPTPESCLPENWHILQKALKYCDIFSPNEVDSANLLGIDISESKSRAKEFVSAFQEFQIGHDSQGWVVLRNGSDGCLIGACTSSTNATSDAVVPVREILHLPSVQMKNGSVLDTTGAGNAFCGAAILEYYRTGNIIEACAKATVAASFVIQQHGLPAHTKNSEGIDLWNGESVFQRLKEYYEFLASHEASAIKELTKRGV
What are the official names of this protein?
Uncharacterized protein C16C9.01c.
Protein: PANC_MYCA1
Sequence: MKPAFTAGELNTYTSPGDVTAVSRALRHTGRRVMLVPTMGALHDGHLALVRAAKRVPGSVVVVSIFVNPLQFSAGEDLDAYPRTLDDDLALLRSEGVEIAFTPTAAAMYPNGLRTTVQPGPLAAELEGGPRPTHFAGVLTVVCKLLQIVRPDRIFFGEKDYQQLVMIRQMVADLNIDVQVVGVPTVREADGLAMSSRNRYLDATQRELAVTLSAALTAGAHAAHLGGAAALRAARAVLDAVPELTVDYLELRDAGLGPAPAHGSARLLVAARLGNTRLLDNIEMQIETPAGTAGPDGDRQYAQSPWRN
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCL12_HUMLU
Sequence: MCEVGVEDLVKAGLSTEEAKYFQRVLEDIVNGAKGLDPSEVWREVVARRLLKPSHPHELHQLLYHSVYANWDVSTRGPPLYWFPSLHQSKKTNLGRLMEKYGSEVLGPLYKDPITSFSLFRKFSVQQPEAYWSIVLKELSVSFQEAPKCILDSADKSKRSGSLLPGSVLNIAECCLLPTSYPMKRDDSPAIVWRDEGYDDSEVNVLTLKELREKVMLVANALDAMFSKGDAIAIDMPMTVNAVVIYLAIILSGFVVVSIADSFAAKEIATRLRVSNAKAIFTQDFILRGGRKFSLYSRVVDAAPHKAIVLPVNGSNLGLQLREQDISWEKFISNVSNQARSNHYTPFYQPVDSLINILFSSGTTGEPKAIPWTQLSPLRCAADTWAHIDAQVGDVFCWPTNLGWVMGPVLLFSSFLSGATLALYHGSPLGHGFGKFVQDSGVTILGTVPSLVKAWKNTQCMKGLDWTKIKVFASTGEASNVDDDLWLSSQAYYQPIIECCGGTELASSYIQGSLVQPQAFGAFSTAAMTVGLVILDENGIPYPDKQECTGEVGLFPLYLGATDRLLNADNEKVYFKGMPLYNGMSLRRHGDILKRTAGGFFIVHGRADDTMNLGGIKTSSIEIERVCNRADESVMETTAVSVAPVSGGPEQLVMFVVLKSGHNNEAERLKKKFSKAIQSNLNPLFKVSFVKIVEEFPRTASNKLLRRVLRDQMKHELLVRSKI
What are the official names of this protein?
Probable CoA ligase CCL12, HlCCL12.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RPA2_RAT
Sequence: MDVDSRWRNLPSGPSLKHLTDPSYAVPPEQQKAALQDLTRAHVDSFNYAVLEGLSHAVQAIPPFEFAFKDERISLTIVDAAISPPAVPKGTICKELNIYPAECRGRRSTYRGKLTADISWAVNGVPKGIIKQFLGXVPIMVKSKLCNLYNLPPQVLIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKSRGLGYTQFGVSIHCVREEHSAVNMNLHYVENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEEDSFFKNSVSQMLRIVMEEGCHTQKQVLDYLGERFRVKLSLPDWYPNAEAAEFLFNQCICIHLKSNTDKFYLLCLMTRKLFALARGECMEDNPDSLVNQEVLTPGQLFLMFLKEKMENWLLSIKIALDKRAQKTNVSINNENLMKIFSMGTELTRPFEYLLATGNLRSKTGLGFMQDSGLCVVADKLNFIRYLSHFRCVHRGADFAKMRTTTVRKLLPESWGFLCPVHTPDGAPCGLLNHLTAVCEVVTKFVYTASIPALLCGLGVTPVDAAPCRPYSDCYPVLLDGVMVGWVDKELAPEVADTLRRFKVLRERRCSSLDGGGPDSHDRKAKPVPRAVPLHHSLQAGEACAEPGAGQRRARWNYGAALHEHCHLRGRGFWWSFHTPGALPSQPAEVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSPLVRPCMYDHYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKFKQGDDSLVFGVKPGDPRVMQKLDNDGLPFIGAKLEFGDPYYGYLNLNTGEGFVVYYKSKENCVVDNIKVCSNDTGSGKFKCVCVTVRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMMPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGMELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTVCGRSDSIDTVSVPYVFRYFVAELAAMNIKVKLDVI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors.  Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit.  Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
What are the official names of this protein?
DNA-directed RNA polymerase I subunit RPA2, RNA polymerase I subunit 2, A127, RPA135.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome.
Protein: RLPA_HELPJ
Sequence: MGWALKKVCFLGVIFLISACTVKKNGVKNLSYKHESLRAYENAKDYDPTTKKATYKRNFFERHFKHHTDSQGNNTKQPLDNGMRDSNAIQRATMHPYQVGGKWYYPTKVDLGEKFDGIASWYGPNFHAKKTSNGEIYNMYAHTAAHKTLPMNTVVKVINVDNNSSTIVRINDRGPFVSNRIIDLSNAAARDIDMVQKGTASVRLIVLGFGGVISKQYEQSFNANYSKILHKEFKVGESEKSVSGGKFSLQMGAFRNQIGAQTLADKLQAENKNYSVKVAFKDDLYKVLVQGFQSEEEARDFMKKYNQNAVLTRE
What is the function of this protein?
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
What are the official names of this protein?
Endolytic peptidoglycan transglycosylase RlpA.
What is the protein family that this protein belongs to?
Belongs to the RlpA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: SUCC_FRATT
Sequence: MNLHEYQAKDLLESYGLKVQKGIVAHNPNEAAQAFDQLGGKFAVVKAQVHAGGRGKAGGVKVVKSSQEAREVAESLIGKNLVTFQTDAEGQPVNSVGVFEDVYPVTRELYLGAVVDRSSRKVTFMASTEGGVDIEEVAHNSPEKILKVEVDPLVGLQPFQAREVAFKLGLEGKQINDFVKTMLGAYKAFIECDFALFEINPLAVRENGEIVCVDGKINLDSNALYRHPKLLALRDKSQENAKELKASEHELNYVALEGNIGCMVNGAGLAMATMDIIQLYGGKPANFLDVGGGATKERVIEAFKLILDDENVKAILINIFGGIVRCDMIAEAIIEAVKEVNVTVPVVVRLEGNNAEKGAKILADSGLKLIPADGLADAADKVVKSLG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: SDE5_ARATH
Sequence: MSKIASSSNSDPDSRSLQVLLDTFGSRFSLDDIAAAYCQASQNVDVAGEILSAMAEKTPQCDQVEMKTATSKPTQVYVPKEVPRQEDSKAKVWRPKRNSISNGTVSSVIGKEYARTRPISNAPKEATKPLKINSRDIPETEIWSEEMRKSNEGKISRAPTDVEEFIVKMLGEGFQASQEVIHQVLGVCGYDVKKSTEKLLDFSDTKKYADVGISNEVMSKVDPQRQSTSCNQMELQKISQSVGARTFTGSQEGRNAKNGLEKEVLEALFSGAERYVDKPKVTRHFGERRPGVAGRPVFKPLEDPFQERVVAVKQSSNTSKEDDDENEFKAHRKAVREHLNQMKEYYGAAAEAFSKGETERAHRLVEKGHFFGQKAREADDKSVAKMIDVNQEDDSTYEEDEVVTVNMNEHEAKEALRLLKRQLIYFSGISSFKYLRVQLGEKKEDFKSKRKHIVKLLEGESIPWTEEDGGLVIMIRVDEIDPKKLSFAKK
What is the function of this protein?
Involved in sense transgene post-transcriptional gene silencing (S-PTGS).  Not involved in repeat-induced transgene silencing (IR-PTGS).  Essential component of the trans-acting short interfering RNA (tasiRNA) pathway.  Required for the production of tasiRNAs (PubMed:17397509, PubMed:20798330).  Acts together with RDR6 in generating double-stranded RNA from specific single-stranded RNAs.  May be involved in the transport of RNA molecules that are converted into a double-stranded form by RDR6.  Involved in virus-induced silencing.  Not involved in the biogenesis of microRNAs and 24 nt siRNAs produced by DCL3 (PubMed:17397509).
What are the official names of this protein?
Putative nuclear RNA export factor SDE5, Protein SILENCING DEFECTIVE 5.
Protein: TA2GE_AGEOR
Sequence: MRAIISVLLISAMVFSIIEAVPLEEGLQLFEAERVGCLPRNRFCNALSGPRCCSGLRCKELSIWASKCL
What is the function of this protein?
Insect active toxin causing rapid but reversible paralysis in crickets.  No activity shown in mammals.  Does not show effect on mammalian voltage-gated calcium channels (By similarity).
What are the official names of this protein?
U2-agatoxin-Ao1e, U2-AGTX-Ao1e, Agel_04.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 01 (U2-agtx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: IAA19_ORYSJ
Sequence: MPPPLEARDYIGLAASPASSSSSCCASTPVAEVVGAHLALRLGLPGSESPARAEAEAVVVDAALTLGPAPPPRGGAKRGFVDSLDRSEGRRAAATAGDDERGVREEEEEEKGLGEAAAGAPRAAKAQVVGWPPVRSYRKNTLAASATKTKGEDQGKSEVGCCYVKVSMDGAPYLRKVDLKTYSSYEDLSLALEKMFSCFITGRSSSHKTSKRDRLTDGSRADALKDQEYVLTYEDKDADWMLVGDLPWDLFTTSCRKLRIMRGSDAAGMAPRSLEQTGQNK
What is the function of this protein?
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
What are the official names of this protein?
Auxin-responsive protein IAA19, Indoleacetic acid-induced protein 19.
What is the protein family that this protein belongs to?
Belongs to the Aux/IAA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: A2MGH_DEIRA
Sequence: MLGAVVVRVTDLNLVSVATPGRVQVWATRLGSGAPVPNVQLSALAVKYDWQDGSRVVSRRTLAPVRTDAQGLATFSLRDGEQLSVRGQVTLGGQPHSAQLGRTENELWTGVAERARALIQTDKPVYRPGETLRGFAVLRRLGAGTRLPYTGPVTVRLRAGYPDATLAQLTVKPDADGLVRFSLPLPQDVKIGGYSLEVELPAAPSASNPNPEPDVSQVPVEVRAFVKPLFTLDLSGPQEVVSGTPLTLSARGELYQGGPANVQAEAFMVDGYASDELYPDYDAGDNGLRYQDLNSDEVYGENAAPGIDPKRRPDQTLTLRGGRATLPLKLQAKNGQPTRYAVALRARDEYGRDVWARRPVTVYPAAIKFVQPRVEGAERRRVSVAVQQVGSGKALAGRRVQAEVVRVFYVTQPDGKSVRREQRISQSVLTSDAAGRVTLNVTLTPGQEGGYVARLSTQDSAGRTARASLDIGSVYKSGAERQAPTLVLSPERSRYQPGDTARLTLNTDLPVGTPLLLSVNAEDRGQVKLIQVTGPTMTLTWPVTAALGPAFSVSAVAVRGGQTAQAFSGELLVPRFDQRLDVQVTAGSEVKPGAEVTFTVRTSRGGQPASALVTLAAVHESVYAVVGDPTPNPWRFLWGATTPQFEIRSSSSQADDGRGGGGGSEAVFYRSDLREVAAFQAVRTDAQGTAKVTVRMPEGLGSYRLSARAFTRTGAAGEARGEQRVGLPFAVRLIRPRVLTAGDTGSVAVSAADRTGQGGNVTLTLGANGQTQTANSPLQGGSATRLFSIKAPQDAQALTLTASAQRGANGERDGLRETVPVRPAGARQLLSGSGSVGADKAGGNASVSLKWPQEAQPESLTLDLAATPLQLALTGLDAALADPADRWVTTDALSARLSSNLDLAALAGPFGWPEVRTRALAQARRDLASLLALRGSDGWGWTEGSPASAEMTARALDALVQAKGAGLTDAVTLQVVRQQAELLLKKSPNSPVLAAGWRGLGPPLRPCDWPAPG
What are the official names of this protein?
Alpha-2-macroglobulin homolog.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.