PharMolix/UniProtQA huggingface dataset:
Protein: QPT2_NICGL
Sequence: MFRAIPFTATVHPYAITAPRLVVKMSAIATKNTRVESLEVKPPAHPTYDLKEVMQLALSEDAGNLGDVTCKATIPLDMESDAHFLAKEDGIVAGIALAEMIFAEVDPSLKVEWYVNDGDKVHKGLKFGKVQGNAYNIVIAERVVLNFMQRMSGIATLTKEMADAAHPAYILETRKTAPGLRLVDKWAVLIGGGKNHRMGLFDMVMIKDNHISAAGGVGKALKSVDQYLEQNKLQIGVEVETRTIEEVREVLEYASQTKTSLTRIMLDNMVVPLSNGDIDVSMLKEAVELINGRFDTEASGNVTLETVHKIGQTGVTYISSGALTHSVKALDISLKIDTELALEVGRRTKRA
What is the function of this protein?
Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (Probable) (PubMed:31276744).  Involved in the catabolism of quinolinic acid (QA) (Probable).
What are the official names of this protein?
Quinolinate phosphoribosyltransferase [decarboxylating] 2, mitochondrial, NgQPT2.
What is the protein family that this protein belongs to?
Belongs to the NadC/ModD family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: COBS_PYRFU
Sequence: MKNLIQFMTRVPIKGDFEKAREEVWMLPLLTPLTAFIPSLILYLNIPLKNVLSILSLYWVIGLLHLDGLADWADGIMVKGDREKKVRAMKDVNTGIAGTFAVVMILLIQVYSLFSAPFYSIYLAELNSKMAMLLALATKKPLGEGLGKYFMDKLTTKRVFLGGVLYALLLIPILLYDPQSIFALLGLVGGIYAVKISLDNFGGLNGDCIGAVGEITRGATLLILGVWA
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: URE2_CERS1
Sequence: MIPGELFPAEGEILLNAERAQITLVVSNAGDRPVQVGSHYHFAETNPALEFDREAARGMRLDIPAGTAVRFEPGQTREVRLVSYAGSREVYGFNGRIMGKL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTSR1_MOUSE
Sequence: MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVYYDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNISHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK
What is the function of this protein?
Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation.  Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization.  Activated by intracellular alkalinization.
What are the official names of this protein?
Cation channel sperm-associated protein 1, CatSper1.
What is the protein family that this protein belongs to?
Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of the sperm tail.
Protein: RM28_YEAST
Sequence: MLAQTFKKPHRAVLEQVSGTTVFIRNKRTKSKSSLSPLAQRVVTQLSVMSASRKQPKLLKLAREDLIKHQTIEKCWSIYQQQQRERRNLQLELQYKSIERSMNLLQELSPRLFEAANASEKGKRFPMEMKVPTDFPPNTLWHYNFRK
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
54S ribosomal protein L28, mitochondrial, Mitochondrial large ribosomal subunit protein mL40, YmL28.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL40 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Protein: LAP1_PYRTT
Sequence: MKSAALLLPLYAAAFAAAAFHHEHAQAVIQEQQLTIVEPDEYLIELSPGETRWVTENEKWELRKKNINFFDITHNAELGTLKRRINAASVEYPSKPVFNETLAPLLKELDKNNMRAHLETFTSFHTRYYKSQYGVQSSAWLLDQVKKTLADAGASKASVKAFPHPWGQSSIIATIPGKSDKTIVIGAHQDSINLFFPAFLAAPGADDDGSGTVTILEALRVLLKSDEILKGEADNTIEFHWYSAEEGGLLGSQAIFQSYEKEARDVKAMLQQDMTGYVQKTLDAGEPESVGVITDFVDPGLTEFIKKIITVYCDIPYVLTKCGYACSDHASASKAGYPSAFVIESDFKYSDNKIHTTEDKIEYLSFDHMLQHARMTLALAYELAFAEFK
What is the function of this protein?
Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.
What are the official names of this protein?
Leucine aminopeptidase 1, Leucyl aminopeptidase 1, LAP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28E subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS18_MARN8
Sequence: MARFFRRRKFCRFTAEGVKEIDYKDLDTLKGYITETGKIVPSRITGTKARYQRQLATAIKRARYLALLPYTDGHDH
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MET24_HUMAN
Sequence: MARERPPGRGCGVLRRCLLGAVLLFGLRLCAELRRAGPGSPTRSAPPGPAWRPPGPHLPPAPGQPRGASRRQVTYVRSGRRAPPGGGGSGTPEPGCCAPRGRPRRKGPRWHIDLQPWAGSAQSLDEEAWRFLRYISTTQIACNHMNTDSLATDSSPTHKPWSVCLDDRFNLAHQIRNKQCRLYSLGLGSDDTHFEVSMANNGCEVHRFDPSVKSAHILESQHLWYHRLSIDWRDPHPAVAAQKPHSNTRKLGSILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQIGQLIFEIHLHWPGFEVSGSDSSVVRFWYSLLKELEQKDFRLFHSYKDLSKPQLFLKKDIFNASSCYTLSWVNTRWK
What is the function of this protein?
Probable methyltransferase.
What are the official names of this protein?
Probable methyltransferase-like protein 24.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RBSK_SCHPO
Sequence: MINIVVLGSMNTDLVMRTKICPSGGETIHGEPDGFSTGNGGKGANQAVAVARLSNPADTKVSMLGCVGDDAFGVEMLSGLKKDGVNVDNVKKIENKSTGVAMIIVEETGENRILLSEGANGNVDTAFVKAMEQRISTCNLLIMQLEIPLEAVEIALQIAHKHGVDVLMNPAPAIPLSHDMISYCAYLVPNEHEAAILLNQADSPATLENVDAYASKLLSFGVRKAVIITLGSQGAYYKSANGESALVSACKVKAVDTTAAGDTFIGAFSNSIAHGQPLKDSLEFAAKCSAITVQRKGAASSIPSLLEVDGSFNLKKNT
What is the function of this protein?
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium.  The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
What are the official names of this protein?
Ribokinase, RK.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL5_FLAJ1
Sequence: MAYTPRLKEEYKSRVISALKEEFGYTNVMQVPKLEKIVLSRGVGAAVSDKKLIDYAVDELTKITGQKAVSTISKKDVASFKLRKGMPIGAKVTLRGERMYEFLDRLITSALPRVRDFGGIKATGFDGRGNYNLGVLEQIIFPEIDIDKVNKISGMDITFVTTAKTDKEAKSLLAELGLPFKKN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: NU4LM_PUSHI
Sequence: MSMVYANIFLAFIMSLMGLLMYRSHLMSSLLCLEGMMLSLFVMMTVTILNNHFTLANMAPIILLVFAACEAALGLLLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RECO_SYNAS
Sequence: MNTRATHKTEGFVLKTLSYSDSDLIVTFYTRNFGKLTAIARGARKSRKRFVNVLEPFCCSSLLFSRKQRDQLAWLESCQVINEFPEIRKSLDRTLLASYLIDLVDHFSIEEKPGRELFELLRSFLLLIEEGDTSERLLRFFEIRHLKLTGYAPALDCCMICKAPLNPQQRYVFNIAQGGLHCRSCYTTPAAPDVLPISVGTIKTLLLGREIETEKMKRILFSGQTARESKSLLSLFIGHILGKELKSLKVLDEIQRMGL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: TSAD_CLOB6
Sequence: MKESINILAIESSCDETSAAVVINGREVLSNIIASQISTHEKFGGVVPEVASRKHIEVISAVVQEALDEANFTLDDIDAIGVTYGPGLVGALLVGLQYAKGLAFATGKPLIGVNHIEGHISANFIEYKDLKPPFMCLVVSGGHTFIVYMKDYGEFEVLGETRDDAAGEAFDKVARAIGLGYPGGPKIDKISKEGNEEAIKFPRANFHDDTLDFSFSGIKSAVLNYLNKKEMKGEEINRADVAASFQKSVVDVLVDNTIKACMSKKVDKIAVAGGVAANSCLRETLVRECKKKGIEVLIPPFILCTDNAAMIGSAAYFEYIKGRRTSLDINAVPNLKLGER
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_STRPD
Sequence: MDTKTLIASEIAKVVPELEQDAIFNLLETPKNSDMGDLAFPAFSLAKVLRKAPQMIASELAEQIDESQFEKVVAVGPYINFFLDKTKISSQVLEQVITAGSDYAQQDEGQGRNVAIDMSSPNIAKPFSIGHLRSTVIGDSLAHIFAKMGYKPVKINHLGDWGKQFGMLIVAYKKWGDEAAVQAHPIDELLKLYVRINAEAETDPTVDEEAREWFRKLEDGDKEATELWQWFRDESLLEFNRLYDQLHVTFDSYNGEAFYNDKMDEVLDLLEAKNLLVESKGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKRTYDFAKSVYVVGNEQAAHFKQLKAVLKEMGYDWSDDMTHVAFGLVTKGGAKLSTRKGNVILLEPTVAEAINRAASQIEAKNPNLADKEAVAHSVGVGAIKFYDLKTDRMNGYDFDLEAMVSFEGETGPYVQYAHARIQSILRKADFTPSATTTYSLADAESWEIIKLIQDFPRIIKRTSDNFEPSIMAKFAINLAQSFNKYYAHTRILDDNSERDNRLALCYATATVLKEALRLLGVDAPNEM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PR5A1_MOUSE
Sequence: MRLSKIQPHQSGTLLLLLLSNLLMWENVASVPRCIMEDGGCQKVLNYIFNMTSTISENFNNLSSETLNDFDTEYDPHQKFQNRPTMTCHTSSRSVPNNKRKAERMRPVVLLNVTIRMLAAWKNLLHHVENNMADLDGTPYVIISKVKLIDRQIKKLTKNLQNIKTILSQVNPDLKKNEDYPAWSGEPYVQQSKRRVQLFGLHSLFFCLNNDAQKVSDFISILRDQIVPNQ
What are the official names of this protein?
Prolactin-5A1, Placental prolactin-like protein L, PLP-L, PRL-like protein L.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HMR1_PANTR
Sequence: MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDILQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQTWASVELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR
What is the function of this protein?
Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells.  In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity).  Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis.  Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity).  May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin.  Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity).  During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity).  Acts as an immune sensor of cancer cell metabolome.  May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity).
What are the official names of this protein?
Major histocompatibility complex class I-related gene protein, MHC class I-related gene protein.
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single- pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=In the absence of antigen remains within the endoplasmic reticulum where it acts as a metabolite sensor. Antigen binding triggers trafficking of the ternary complex to the plasma membrane. After presentation, most of these complexes are rapidly internalized and degraded via endocytosis. A small subset recycles via endosomes back to the plasma membrane and may thus acquire and present new antigens that do not efficiently reach the endoplasmic reticulum.
Protein: NADD_RHILO
Sequence: MPHAEKGLTVGLFGGSFNPPHAGHALVAEIALRRLALDQLWWMVTPGNPLKSTRELAPLAERLQLSEQIARNPKIKVTAFEAAHHVRYTADTLALVKARNPGVDFVWIMGADSLRDFHRWQRWREIVLTFPIAVIDRPGATLSFLSSVVAKTFDYARIDEGDAPLLARMRAPAWTFIHGPRSSLSSSAIRKMAKG
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: TRHO_STAEQ
Sequence: MDYRVLLYYKYVTIDDPETFAAEHLKFCKEHHLKGRILVSTEGINGTLSGTKEDTDKYIEHMHADSRFADLTFKIDEAESHAFKKMHVRPRREIVALDLEEDINPREITGKYYSPKEFKAALEDENTVILDARNDYEYDLGHFRGAIRPDITRFRDLPEWVRNNKEQLDGKNIVTYCTGGIRCEKFSGWLVKEGFENVGQLHGGIATYGKDPETKGLYWDGKMYVFDERISVDVNQIDKTVIGKEHFDGTPCERYINCANPECNKQILVSEENEEKYLGACSYDCAKHERNRYVARHHISNEEWQRRLNNFKDVPEHTHA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: LPXD_CAMLR
Sequence: MKISEIAKFLGIEYYGDDIEITALNSLNNASFSELSYCDGEKNSKKIASSGAGAILISKEFENLVSKDCVKLVVDNPHLSFALLSKLFAKPLISSEKKQSNIAKSAKIMPNVYIGENVQIADHVVIMAGAYIGDNVSIGEYTIIHPNAVIYNDTKIGKKCHLLANCVIGSDGFGYAHTKNGEHYKIYHNGNVILEDFVEVGACTTIDRAVFESTIIKQGTKIDNLVQVGHNCEIGENCLIVAQSGISGSSILGKNVTMGGQSATSGHLEIGDFATIAARGGVTKNLEGARVYGGFPIMLQKDWLKFQAKIITAFRDKHE
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: DNAK_BURTA
Sequence: MGKIIGIDLGTTNSCVAIMEGNQVKVIENSEGARTTPSIIAYMDDNEVLVGAPAKRQSVTNPKNTLFAVKRLIGRRFEEKEVQKDIGLMPYSIIKADNGDAWVEAHGEKLAPPQVSAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKAEKGDRKIAVYDLGGGTFDVSIIEIADVDGEKQFEVLSTNGDTFLGGEDFDQRIIDYIIGEFKKEQGVDLSKDVLALQRLKEAAEKAKIELSSGQQTEINLPYITADASGPKHLNLKITRAKLEALVEDLVERTIEPCRIAIKDAGVKVSDIDDVILVGGQTRMPKVMEKVKEFFGKDPRRDVNPDEAVAVGAAIQGQVLSGDRKDVLLLDVTPLSLGIETLGGVMTKMINKNTTIPTKHSQVYSTADDNQGAVTIKVFQGEREMAAGNKLLGEFNLEGIPPAPRGVPQIEVTFDIDANGILHVGAKDKATGKENKITIKANSGLSEAEIEKMVKDAEANAAEDHKLRELAESRNQGDALVHSTKKALTEYGDKLEAGEKEKIEAALKELEDVLKNASSDKAAIDAKIETVATASQKLGEKMYADMQAQQAGAAGAAGAAAAEGAAQGGAQTADDVVDADFKEVKKD
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: EFP_ONYPE
Sequence: MINTNDFKTGQTIKFNNQIYQILEFLHVKPGKGAAFVRTKLRNLRTGSVIDYTFNAGIKVQPALITKIKMQFLYALEDNYIFMNTQNYEQLEINKHQLKDFLKYLYEGLLVDIIFYENDEIVGITLPDKISIKVAYTEPGAKGDTKTNSLKDAALETGLVIKVPLFINIGEKIIINTETGLYLSRDNNK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICP27_HHV2H
Sequence: MATDIDMLIDLGLDLSDSELEEDALERDEEGRRDDPESDSSGECSSSDEDMEDPCGDGGAEAIDAAIPKGPPARPEDAGTPEASTPRPAARRGADDPPPATTGVWSRLGTRRSASPREPHGGKVARIQPPSTKAPHPRGGRRGRRRGRGRYGPGGADSTPKPRRRVSRNAHNQGGRHPASARTDGPGATHGEARRGGEQLDVSGGPRPRGTRQAPPPLMALSLTPPHADGRAPVPERKAPSADTIDPAVRAVLRSISERAAVERISESFGRSALVMQDPFGGMPFPAANSPWAPVLATQAGGFDAETRRVSWETLVAHGPSLYRTFAANPRAASTAKAMRDCVLRQENLIEALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLENLATRLRPFLQCYLKARGLCGLDDLCSRRRLSDIKDIASFVLVILARLANRVERGVSEIDYTTVGVGAGETMHFYIPGACMAGLIEILDTHRQECSSRVCELTASHTIAPLYVHGKYFYCNSLF
What is the function of this protein?
Multifunctional regulator of the expression of viral genes that contributes to the shutoff of host protein synthesis and mediates nuclear export of viral intronless mRNAs.  Also stimulates translation of viral transcripts (PubMed:25540385).  Independently, plays a role in the regulation of virion release (PubMed:25540385).  Also plays a role in the inhibition of host innate immune response by targeting host IRF3 and therby preventing production of beta-interferon (PubMed:30863402).  Silences the 3' splice site of the host promyelocytic leukemia (PML) intron 7a, thereby switching PML isoforms from PML-II to PML-V.  This could be linked to the accelerated mRNA export induced by ICP27 which might not provide sufficient time for PML pre-mRNA to be spliced in the nucleus (PubMed:19729513).  Suppresses also splicing of the viral ICP34. 5 mRNA, allowing the virus to express a variant form of ICP34. 5 (PubMed:23487469).
What are the official names of this protein?
mRNA export factor, Immediate-early protein IE63, Infected cell protein 27, ICP27, VMW63.
What is the protein family that this protein belongs to?
Belongs to the HHV-1 ICP27 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: PYRB_BACCZ
Sequence: MSHLLTMSELSEVEISEILKDAEDFANGKESKTTEQTFVANLFFENSTRTRFSFEVAEKRLGLDVLNFSADASSVQKGETLYDTIRTLESIGTKAVVIRHEQDRYFDELKDQVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLKIAIVGDVRHSRVARSNAEALTKLGATIYFASPEEWKDEDNTFGTYKPLDELVPEVDVMMLLRVQHERHDHYETDIMKEYHEKHGLTVEREKRMKEGSIIMHPAPVNRDVEIASELVECERSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELFV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: AGRE2_MACMU
Sequence: MGGRVFLAFCVWLTLLGAETQDSRDCARWCPENSSCVNATACRCNPGFSSSSEIFTSPTEICDDINECVPPSKVSCGKSSDCRNTEGSYDCVCNPGYELVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSFTCQCLPGFKFKPEDPKLCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTICEDVDECSSGLHQCDNSTVCFNTVGSYTCRCRPGWEPKHGIPNNQKDTVCKDMNFPTWTLPPGVHSQTLSQFFNKVQDLDRDFKTSSAKVTIQSILKELDELLEAPGDLETLPRFQQHCVATHLLDGLEDVLRGLSKNPSIGLLNFSYPAGTEFSLEVQKQVDRNVTLRQNQATMQLHWNLAQKSGDPGPSVVGLVSVPGMGKLLAEAPLVSEPENQVVRNETHQGLLPILLSDVISAFLSNNDTQNLSSPVTFIFSHRSVIPRRKVLCVFWEHGQNGCGHWATTGCSTMDTRDTSTICRCTHLSSFAVLMAPYDVQEEDPVLTVITYMGLSLSLLCLLLAALTFLLCKAIQNISTSLHLQLSLCLLLAHLLFLVAIDRTEHEVLCAIIASALHYLYLAAFTWMLLEALYLFLTARNLMVVNYSSINRFTKKLMFPVAYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLALLLVTLWILKNRLSSLNNEVSTLQNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQYRKWSKGFRKLRTESEMHTLSSSAKRDTPKPSTPGLLGLQS
What is the function of this protein?
Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment.  Promotes granulocyte chemotaxis, degranulation and adhesion.  In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.  Signals probably through G-proteins.
What are the official names of this protein?
Adhesion G protein-coupled receptor E2, EGF-like module receptor 2, EGF-like module-containing mucin-like hormone receptor-like 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells.