PharMolix/UniProtQA huggingface dataset:
Protein: NSP1_ROTHL
Sequence: MATFKDACYQYKKLNKLNNAVLKLGANDVWRPSTLTKCKGWCLDCCQYTDLTYCQGCLIYHVCEWCSQYSRCFLDDNPHLLRMRTFRNEITKDDLENLINMYNTLFPINQKIVHKFANIIKQHKCRNEYLTQRYNHFLMPITLQSLSIELDGDIYYIFGYYDDMHKINQTPFSFTNLISKYDILLLDSINFDRMAFLPLTLQQEYALRYFSKSRFITEKRKCIKISHFSDNILDNLHDPNFTLQVIRNCSNMSVEWNEACNLIRNINDYFDILKSSRTEFYDISPRCRMFTQYKLKIASKLIKPNYVASNHNSLATEVHNCKWCSINNNSIVWDDFRIKNVYNDIFNFIRALVKSNLYVGHCSSEEKIYESVKDVLNVCKENEWNILVTEMFNQLEPIKLNDNNYILLNYEINWNVMNVLINSIGKVPKILTLSDVILILRIIIYDWFDIRFMRNTPMTTFTVNKLKQLYEKDRPAEHDSGVSDVE
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7.  Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.  Recognizes the host NF-kappa-B regulator BTRC through the presence of a DSGXS motif in the C-terminal substrate recognition domain.
What are the official names of this protein?
Non-structural protein 1, NSP1, NCVP2, Non-structural RNA-binding protein 53, NS53.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP1 family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton.
Protein: MENE_STAA2
Sequence: MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRLTPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNGLLDNTMGIQYDTSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSKHLAKYKVPKHFEKVDTLPYTSTGKLQRNKLYRG
What is the function of this protein?
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
What are the official names of this protein?
2-succinylbenzoate--CoA ligase, o-succinylbenzoyl-CoA synthetase, OSB-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
Protein: RP28_BACAN
Sequence: MSLFAAIGYMVREVFVFVSYVKNNAFPQPLSSDDERKYLELMEQGDAQARNLLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKAIESYSAGKGTKLATYAARCIENEILMHLRVLKKTKKDVSLHDPIGQDKEGNEISLIDILKSESEDVIDMIQLSMELEKIKEYIDILDEREKEVIVKRFGLGLDKEKTQREIAKALGISRSYVSRIEKRALMKMFHEFVRAEKEKKAKE
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor directs the transcription of crystal protein genes, a sporulation-regulated event (By similarity).
What are the official names of this protein?
RNA polymerase sigma-28 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: ISPDF_RHILW
Sequence: MLQMPSKQPISAGIVIVAAGRGERAGSSKEGPKQYRMIGGKPVIVHTLENFMTWEPATEIVVVIHPDDEALFARALRHIISATPIETVHGGPTRQQSVLAGLRHLKDKRISHVLIHDAVRPFFDHVLLDRIAESLDNGAQAVLPAIPVTDTLKRADSAGTVLTTVSREHLYAAQTPQSFAFETILDAHEKAAASGRSDFTDDASIAEWAGIPVTIVAGTPDNVKLTVKKDIAMADDKLSASLLPDVRTGNGYDVHQLEAGDGVTLCGVFIPHDQKLKGHSDADVALHALTDALLATCGAGDIGDHFPPSDPQWKGAASRIFIEHAARIVREHGGTIMNADVSLIAEAPKVGPHRESMRMRLSEYLGIDIERCSVKATTNETIGFVGRREGIAAIATATVVYRGVKR
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: SYY_SALEP
Sequence: MASSNLIKQLQERGLVAQVTDEDALAERLAQGPVALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVAKIRKQVAPFLDFDCGENSAIAANNYDWFGSMNVLTFLRDIGKHFSVNQMINKEAVKQRLNRDDQGISFTEFSYNLLQGYDFACLNKLHGVALQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMDIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLVAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDAELQPSRGQARKTIASNAVTINGEKQSDPEYIFNDEDRLFGRYTLLRRGKKNYCLICWK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALR_BOVIN
Sequence: MLLPVPLLLGLLGLAAADPTVYFKEQFLDGDGWTERWIESKHKPDFGKFVLSSGKFYGDQEKDKGLQTSQDARFYALSARFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPAGLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPNNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPEDWDDRAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPEYKGIWIHPEIDNPEYSPDSNIYAYENFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLHEEEEEKKGKEEEEADKDDDEDKDEDEEDEDEKEEEEEEDAAAGQAKDEL
What is the function of this protein?
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle.  This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER.  Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity).  Involved in maternal gene expression regulation.  May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).  Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity).
What are the official names of this protein?
Calreticulin, CRP55, Calregulin, HACBP.
What is the protein family that this protein belongs to?
Belongs to the calreticulin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Cytolytic granule. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity). In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity).
Protein: ISF3_ARCFU
Sequence: MKLLAINGSPNKRNTLFLLEVIAEEVKKLGHEAEIIHLKDYEIKECKGCDACLKGDCSQKDDIYKVLEKMQEADAIVIGTPTYFGNVTGIVKNLIDRSRMARMGNYRLRNRVFAPVVTSGLRNGGAEYAAMSLIVYALGQAMLPVSIVENPITTGTFPVGVIQGDAGWRSVKKDEIAINSAKALAKRIVEVAEATKNLRES
What is the function of this protein?
Redox-active protein probably involved in electron transport.
What are the official names of this protein?
Iron-sulfur flavoprotein AF_1896, AF-3, Af3, Isf-3.
What is the protein family that this protein belongs to?
Belongs to the SsuE family. Isf subfamily.
Protein: RK9_IPOTF
Sequence: MAAYSAAALSWSSSSLLGNYKLSKNAPLGTAKLVERTSNFTIVCQKKTKKIRKIILKEDVQELGKKGQLMNVRAGYYRNYLLPMGMAQIVTPQLLKEMKIEEERIEAEKKRVKEEAQQLALIFETVGGFKVKRKGGKGKQIFGSVTAQDLVDIIKAQLQREVDKRIVSLPEIRETGAYTAELKLHPEVTARVQVIVSAN
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9, chloroplastic, CL9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLPP_ORYSI
Sequence: MPIGVPKVPYRIPGDEEATWVDLYNVMYRERTLFLGQEIRCEVTNHITGLMVYLSIEDGISDIFLFINSPGGWLISGMAIFDTMQTVTPDIYTICLGIAASMASFILLGGEPTKRIAFPHARIMLHQPASAYYRARTPEFLLEVEELHKVREMITRVYALRTGKPFWVVSEDMERDVFMSADEAKAYGLVDIVGDEMLDEHCDTDPVWFPEMFKDW
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: ZH15B_DANRE
Sequence: MALSRALRCCQRIFSWIPVIIISSVVLWSYYAYVFELCFVTLSNNLERVTYLLIFHVCFIMFCWTYWKAIFTPPSTPTKKFHLSYTDKERYEMEERPEVQKQILVDIAKKLPIFTRAQSGAIRFCDRCQVIKPDRCHHCSVCETCVLKMDHHCPWVNNCVGFSNYKFFLLFLSYSMIYCVFIASTVFQYFLKFWVGDLPNGPAKFHVLFLLFVALMFFVSLMFLFGYHCWLVAKNRSTLEAFSPPVFQNGPDRNGFNVGLSKNLRQVFGEHKKLWFIPVFTSQGDGHYFPLRTLRESENPLLANEEKWVEDGGSDEESADENGSSLLIRTES
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:29326245).  Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).  May thereby regulate target proteins association and localization to membranes (By similarity).  In the nervous system, probably catalyzes the palmitoylation of synaptic proteins and is involved in the differentiation of dopaminergic neurons and the development of the diencephalon (PubMed:26095893).
What are the official names of this protein?
Palmitoyltransferase ZDHHC15B, Acyltransferase ZDHHC15B, Zinc finger DHHC domain-containing protein 15B.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Postsynaptic density.
Protein: ATG4_CRYNB
Sequence: MSSPTSTSPKSSFVFSPTSFPHAAIASNNVRPRTNLPPPPPPDRIPPPKGRSHQQKFKILRKEKDKDRRQPIDLEDDWTIEDVTVNGDGVEQESQYLDDLQPEENELKPGPRFLEMANREEKKEKTSKSRGLVKKTSRLFGRDKDKDRGKPEEPAVTGSSSSTLAAMRQSSSTSTDSTTSRSITSAFTRQNSIQSRRSPRTSFGQAHSRRASQDSQMSWPAPRSIRSSTTSHDPSSDPQNSASSTGVPIPQRQGASMSSLSRYSLPHPNGGTSRSPDTFPNKMSTWFSHLLPVSSGSPPSSSYETSSSIRKQSSVAASLFNAARQKAVDGVRHLLDSEAQPDKCMDTIWVRGVAHPGWRPITPENSTSNLPALEPGGSGGGVEDRRASLSMNGPSPNSLRPSSWKRNTSLPPTGQPQSPAHVHTQASNQTTSPSKGFTGIWNPSTLSLGMPIGGSPNKEKENGSGAESPSKKKSKEIVKWPEQFYDDFKSTVWFTYRNQYAPISSLSPNLLIPSPEAYYASFGPPLDATSPSSLRVTTPTAAAQQSASGSGGWGWSKEERGLTSDAGWGCMLRTGQSLLVNALIHIHLGRDWRVPSTPASFSEATTTQEIAALKDYAKYAQMLSWFLDDPSPLCPFSVHRMALIGKELGKEVGEWFGPSTAAGALKTLANSFAPCGVAVATATDSIIYKSDVYTASNLPSDDWNSISPTFNSSKKKRRGDNEAKEEKWGKRAVLILVGVRLGLDGVNPIYYDSIKALFTFPQSVGIAGGRPSSSYYFVGSQANHLFYLDPHLTRPAIPLQIPPLPVHSAKEKGSTESSSIMSTAEEESEEGVMIRTPETPRSTTPSMFSAPEHVEDEDQEEWGQGSKYKLDVVDADGVEVEGIDDDKGRNEGKMIREEVPKSSFESNGAAQEQPKKQKGFTSTASIDSQVDSQVDPHMLWYTTAYPDPLLRTYHCEKIKKMPLSGLDPSMLLGFVCKDEDDFEDFVERVAQLPKKIFTVQDEMPSWEEDDDAGLESVSEPDFEGDEFEEPGTAKPRFDSSSPVNEDSLKGPRVVSASTTATPLAAKEEDHLDVEEANSTDDDNESIGTTTAAGPMDIARHLNRVDLSSKREQEGDDDDGEWVGGTPSSQGVLVEPPSLKGTPSKSRSSAFEPRYEQNGETEQERPVFPARNRMESWVEPVCEGKEAPNGDNLL
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: HXD3_SHEEP
Sequence: RGPDAPGPASKRVRTAYTSAQLVELEKEFHFNRYLWRRRRVEMANP
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-D3, Homeobox protein Hox-7.1, OHox-7.1.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1992_YERP3
Sequence: MGYFIDRRLNGKNKSMVNRQRFLRRYKSQIKQSIADAINKRSVTDIESGESVSIPIDDINEPMFHQGNGGLRHRVHPGNDHFITNDRVDRPQGGGGGGSGQGNAGKDGEGEDEFVFQISKDEYLDLLFEDLALPNLKRNQYKQLAEFKTHRAGYTSNGVPANISVVRSLQNSLARRTAMTASKRRELRELEAALTVLENSEPAQLLEEERLRKAITELKQKIARVPFIDTFDLRYKNYERRPEPSSQAVMFCLMDVSGSMDQATKDMAKRFYILLYLFLSRTYKNVDVVYIRHHTQAKEVDEQEFFYSQETGGTIVSSALKLMDEVVQERYNPAQWNIYAAQASDGDNWADDSPLCHELLAKKILPVVRYYSYIEITRRAHQTLWREYEDLEEKFDNFAIQHIREPEDIYPVFRELFHKQTVDN
What are the official names of this protein?
UPF0229 protein YpsIP31758_1992.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: CCME_ECOLI
Sequence: MNIRRKNRLWIACAVLAGLALTIGLVLYALRSNIDLFYTPGEILYGKRETQQMPEVGQRLRVGGMVMPGSVQRDPNSLKVTFTIYDAEGSVDVSYEGILPDLFREGQGVVVQGELEKGNHILAKEVLAKHDENYTPPEVEKAMEANHRRPASVYKDPAS
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side. Note=Stabilized by CcmD in the membrane.
Protein: RL3_KARMG
Sequence: MSGIIGKNIGMTSMYDESGFNVPCSIIEAGPCIVLQIKTKEKDGYDSCQLGFDEKKYKNTNKPLLFFFKKFKSTPKKKIFELPIKGNIKSGNIIKLNCFHENELVNITGFSKGKGFQGVVKRHGFSGVGERSHGQHNRSRAPGSIGAGSDPSRVFKGTRMAGRMGNKKVTLKNRKILKIDLLNNFLIIKGSVPGAKNSYLIIKKLK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: TTL10_MACFA
Sequence: MGSSQEEGLPCQPSQPDHDTGGHGGPDLEGAGRVSTTPGPPGLLTSHPPADSDDTDATGPPAALLEGLLLGDGKPSPHSTRPGPFFYIGGNNGAAIISSYCKSKGWRRIQDSRREDYVLKWCEVKSRDSYGSFREGEQLLYQLPNNKLLTTKIGLLSTLRGRAWAMSKASKAPGGTQARLGKDATAPTLEDLPWTSPGHLRPQRVLRMEEFFPETYRLDLKHEREAFFTLFDETQIWICKPTASNQGKGIFLLRNQEEVAALQAKTRRAEDDPIHHKSPFRGPQARVVQRYIQNPLLLDGRKFDVRSYLLIACTTPYMIFFSHGYARLTLSLYDPHSSDLSGHLTNQFMQKKSPLYVLLKEDTVWSMERLNRYINTTFWKARGLPKDWVFTTLTKRMQQIMAHCFLAAKSKLECKLGYFDLIGCDFLIDDNFKVWLLEMNSNPALHTNCEVLKEVIPGVVIETLDLALETFQKSLRGQKMLPLLSQRRFVLLHNGEADVWPRLGGSCSLRRRLPPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGTGDRHPEQEPSPGTAKEEREEPENARPWGGHPRPTPHAPATLPAFRDL
What is the function of this protein?
Polyglycylase which modifies both tubulin and non-tubulin proteins, generating polyglycine side chains of variable lengths on the gamma-carboxyl groups of specific glutamate residues of target proteins.  Involved in the elongation step rather than the initiation step of the polyglycylation reaction.  Polyglycylates alpha-tubulin and beta-tubulin.  Polyglycylates non-tubulin proteins such as nucleosome assembly protein NAP1.
What are the official names of this protein?
Protein polyglycylase TTLL10, Tubulin--tyrosine ligase-like protein 10.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme.
Protein: COXX2_BACSU
Sequence: MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTGMWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVTGKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTVVGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPMLPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKNIMKWATQMFVYSLNYMTIYFVAMVVLTLF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase 2, Heme B farnesyltransferase 2, Heme O synthase 2.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TM129_HUMAN
Sequence: MDSPEVTFTLAYLVFAVCFVFTPNEFHAAGLTVQNLLSGWLGSEDAAFVPFHLRRTAATLLCHSLLPLGYYVGMCLAASEKRLHALSQAPEAWRLFLLLAVTLPSIACILIYYWSRDRWACHPLARTLALYALPQSGWQAVASSVNTEFRRIDKFATGAPGARVIVTDTWVMKVTTYRVHVAQQQDVHLTVTESRQHELSPDSNLPVQLLTIRVASTNPAVQAFDIWLNSTEYGELCEKLRAPIRRAAHVVIHQSLGDLFLETFASLVEVNPAYSVPSSQELEACIGCMQTRASVKLVKTCQEAATGECQQCYCRPMWCLTCMGKWFASRQDPLRPDTWLASRVPCPTCRARFCILDVCTVR
What is the function of this protein?
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2.  Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase TM129, RING-type E3 ubiquitin transferase TM129.
What is the protein family that this protein belongs to?
Belongs to the TMEM129 family.
Protein: RS17_MANSM
Sequence: MTDKIRTVQGRVISDKMDKSFTIAIERKVKHPLLGKFIRRTTKLHVHDENNEARIGDTVEIKECRPVSKTKSWTLVRVVEKAVEA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ATPAM_ORYSJ
Sequence: MEFSPRAAELTTLLESRMTNFYTNFQVDEIGRVVSVGDGIARVYGLNEIQAGEMVEFASGVKGIALNLENENVGIVVFGSDTAIKEGDLVKRTGSIVDVPAGKAMLGRVVDALGVPIDGKGALSDHERRRVEVKAPGIIERKSVHEPMQTGLKAVDSLVPIGRGQRELIIGDRQTGKTAIAIDTILNQKQMNSRGTNESETLYCVYVAIGQKRSTVAQLVQILSEANALEYSILVAATASDPAPLQFLAPYSGCAMGEYFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKRSDQTGAGSLTALPVIETQAGDVSAYIPTNVISITDGQICLETELFYRGIRPAINVGLSVSRVGSAAQLKAMKQVCGSLKLELAQYREVAAFAQFGSDLDAATQALLNRGARLTEVSKQPQYEPLPIEKQIVVIYAAVNGFCDRMPLDRISQYEKAILSTINPELLKSFNEKGGLTNERKIELDAFLKQTAKEIN
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.  Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
What are the official names of this protein?
ATP synthase subunit alpha, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Protein: RS7_SHEHH
Sequence: MPRRRVVGQRKILPDPKFKSELLAKFINVIMQDGKKSTAEKIIYKALDTASEKKGEDHLVILEAALDNVRPSVEVKSRRVGGSTYQVPCEVRPVRRNALAMRWLVEAARKRGEKSMALRLAGEMLDASENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RNH2_ALKEH
Sequence: MDTLPLDGRASVLLAGVDEVGRGPLAGAVVAAAVILDPDRPIAGLRDSKRLSAARRSELDRRIRAQALAVSLGRAEVAEIDRLNILQASMLAMQRAVAGLDPAPVQALVDGNRAPALPCPAQAIVKGDDRVPAIAAASILAKQARDAEMRALAEQYPGYGFERHMGYPTTEHLQALRTLGACPAHRRSFAPVRRCLLG
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNCB_ENT38
Sequence: MTQFASPVLHTLLDTDAYKLHMQQAVFHHYYDVQVAAEFRCRGDDLLGIYADSIREQVDAMQHLALQDDEYQWLSGLPFFKADYLDWLRDFRFNPEQVTITNDNGKLNIRLAGPWREVIMWEVPLLAVISEIVHRYRSPEMGVEHALATLESKLGEFAQMTESVDMSRFRLMDFGTRRRFSREVQQAIVKRLQQEPWFVGTSNYDLARRRNLTPMGTQAHEWFQAHQQISPDLATSQRAALAAWLEEYPDQLGIALTDCITMDAFLRDFGPEFAQRYQGLRHDSGDPVEWGEKAIAHYKKLGIDPLTKVLVFSDNLDLSKALELYRHFSARVNLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPQIKKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: ERPA_FRATH
Sequence: MSEVVQSVDPINFTEAASLKVKELIEEEGDNSLSLRVYITGGGCSGFQYAFAFDNEVKEDDMVITKNGVRLLVDSMSFQYLVGADVDYKDDVEGAYFVIRNPNAKTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.