PharMolix/UniProtQA huggingface dataset:
Protein: PCNA1_PYRAE
Sequence: MAKQVLTYIDAKEFAYIIDSISVLVEEANFLIRNDGLYLRALDVSRTAMVDLAIPKESFEEFPEVEELRFGLNFKELKKLLRRVKKGDKISMEFEEGRVRIKLIGKSVRSIVVPSIEVVGEELPTPKVVYTAMVKAASDVLATAVKDADAVADEVKFEASEEALIISASSDKGEVEVKLDKNSELVYEFDVKEPASARFSLEYLVDITSKTSKISDIVTIELATAKPIYLSFDIPAGGKISYFIAPRVE
What is the function of this protein?
Sliding clamp subunit that acts as a moving platform for DNA processing.  Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
What are the official names of this protein?
DNA polymerase sliding clamp 1, Proliferating cell nuclear antigen homolog 1, PCNA 1.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: LSPA_METEP
Sequence: MTAFRSGLIALLATLALDQASKLWLYFGTDLVMTQPWRLAPFADFVVVWNRGVSYGLFQQEGGLGRWLLVAVSLAAVIGLSVWMRRAGSRLLAVALGLIVGGALGNAIDRAAYGAVFDFVHLHAGPWSWYVFNVADAAIVAGVVGLILDSLRPAPRAPSTDVAGNGGHPQA
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSH2_RAT
Sequence: MAVQPKETLQLEGAAEVGFVRFFEGMPEKPSTTVGLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKTLQTVVLSKMNFESFVKDLLLVRHYRVEVYKNKAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMATSIGIMGIKLSTVDGQRQVGVGDVDSTQRKLGLCEFPDNDQFSNLEALLIQIGPKECILPGGETAGDMGKLRQVIQRGGILITERKRIDFSTKDIYQDLNRLLKGRKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAAFLNKCKTAQGQRLVSQWIKQPLMDKNRIEERLNLVEAFVEDSELRRALQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGVKQLPNVIQALEKYQGRHQALLLAVFVTPLTDLRSDFSKFQEKIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLISAARGLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSGYVEPMQTVNDVLAHLDAVVSFAHVSNAAPVPYVRPVILEKGKGRIIVKASRHACVEVQHDVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATNIGAFCMFATHFHELTALASQIPTVNNLHVTALTTEETLTMLYQVKTGVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQSIGTSQGHDETQPAAKRRCLEREQGEKIILEFLSKVKQVPFTDLSEESVSVKLKQLKAEVLAKNNSFVNEIISRVKAP
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair.  When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs.  MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.  MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long.  After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions.  The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone.  This transition is crucial for mismatch repair.  MutS alpha may also play a role in DNA homologous recombination repair.  In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
What are the official names of this protein?
DNA mismatch repair protein Msh2, MutS protein homolog 2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CHIX_PEA
Sequence: MKRTLKVSFFILCLLPLFLGSKAEQCGSQAGGAVCPNGLCCSKFGFCGSTDPYCGDGCQSQCKSSPTPTIPTPSTGGGDVGRLVPSSLFDQMLKYRNDGRCAGHGFYTYDAFIAAARSFNGFGTTGDDNTKKKELAAFLAQTSHETTGGWPTAPDGPYAWGYCFVSEQNTQEVYCSPKDWPCAPGKKYYGRGPIQLTHNYNYGLAGQAIKEDLINNPDLLSTNPTVSFKTAIWFWMTPQANKPSSHDVITGRWTPSAADSSAGRVPGYGVITNIINGGIECGHGQDNRVDDRVGFYKRYCQIFGVDPGGNLDCNNQRSFA
What is the function of this protein?
Defense against chitin-containing fungal pathogens.
What are the official names of this protein?
Endochitinase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
Protein: RL22_SORC5
Sequence: MVSKASAMFSRIAPRKARMIADLVRGRDADEAIQLLSFTQKSGAPVLRKIIESAVANAQQAGADIDALFISKATVDKGPNKFNRRWRPRAMGRATRITKGVSHIVIEVDERK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: IRAP_ECO27
Sequence: MKNLIAELLFKLAQKEEESKELCAQVEALEIIVTAMLRNMAQNDQQRLIDQVEGALYEVKPDASIPDDDTELLRDYVKKLLRHPRQ
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraP.
What is the protein family that this protein belongs to?
Belongs to the IraP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: D39U1_BOVIN
Sequence: MRVLVGGGTGFIGTALTQLLKARGHEVTLISRKPGPDRITWDDLTTSGLPRCDAAVNLAGENILNPLRRWNAAFQKEVLSSRLETTQTLARAIAKAPQPPQAWVLVTGVAYYQPSLTAEYDEDSPGGDFDFFSNLVTKWEAAARLPGDSTRQVVVRSGVVLGRGGGAIGHMLLPFRLGLGGPIGSGHQFFPWIHIRDLAGILAHALETSHVQGILNGVAPASSTTNAEFARALGTALGRPAFIPLPSAVVQAVFGRERAVMLLEGQKVVPRRTLAAGYRYSFPELGAALKEVIA
What is the function of this protein?
Putative NADP-dependent oxidoreductase.
What are the official names of this protein?
Epimerase family protein SDR39U1, Short-chain dehydrogenase/reductase family 39U member 1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
Protein: Y2144_ARATH
Sequence: METRSKLMLLACATFSIISLVKSQNQQGFISLYCGLPSNESPYIEPLTNLTYISDVNFVRGGKTGNIKNNSDIDFTSRPYKVLRYFPEGIRNCYSLSVKQGTKYLIRTLFFYGNYDGLNTSPRFDLFLGPNIWTSVDVQKVDGGDGVIEEIIHVTRCNILDICLVKTGTTTPMISAIELRPLRYDTYTARTGSLKKILHFYFTNSGKEVRYPEDVYDRVWIPHSQPEWTQINTTRNVSGFSDGYNPPQDVIKTASIPTNVSEPLTFTWMSESSDDETYAYLYFAEIQQLKANETRQFKILVNGVYYIDYIPRKFEAETLITPAALKCGGGVCRVQLSKTPKSTLPPQMNAIEIFSVIQFPQSDTNTDEVIAIKNIQSTYKVSRISWQGDPCVPIQFSWMGVSCNVIDISTPPRIISLDLSSSGLTGVITPSIQNLTMLRELDLSNNNLTGVIPPSLQNLTMLRELDLSNNNLTGEVPEFLATIKPLLVIHLRGNNLRGSVPQALQDRENNDGLKLLRGKHQPKSWLVAIVASISCVAVTIIVLVLIFIFRRRKSSTRKVIRPSLEMKNRRFKYSEVKEMTNNFEVVLGKGGFGVVYHGFLNNEQVAVKVLSQSSTQGYKEFKTEVELLLRVHHVNLVSLVGYCDKGNDLALIYEFMENGNLKEHLSGKRGGPVLNWPGRLKIAIESALGIEYLHIGCKPPMVHRDVKSTNILLGLRFEAKLADFGLSRSFLVGSQTHVSTNVAGTLGYLDPEYYQKNWLTEKSDVYSFGIVLLEIITGQPVIEQSRDKSYIVEWAKSMLANGDIESIMDRNLHQDYDTSSSWKALELAMLCINPSSTLRPNMTRVAHELNECLEIYNLTKRRSQDQNSSKSSGHTVTFISDIPSAR
What are the official names of this protein?
Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14440.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ODB2_PSEAE
Sequence: MGTHVIKMPDIGEGIAEVELVEWHVQVGDSVNEDQVLAEVMTDKATVEIPSPVAGRILALGGQPGQVMAVGGELIRLEVEGAGNLAESPAAATPAAPVAATPEKPKEAPVAAPKAAAEAPRALRDSEAPRQRRQPGERPLASPAVRQRARDLGIELQFVQGSGPAGRVLHEDLDAYLTQDGSVARSGGAAQGYAERHDEQAVPVIGLRRKIAQKMQDAKRRIPHFSYVEEIDVTDLEALRAHLNQKWGGQRGKLTLLPFLVRAMVVALRDFPQLNARYDDEAEVVTRYGAVHVGIATQSDNGLMVPVLRHAESRDLWGNASEVARLAEAARSGKAQRQELSGSTITLSSLGVLGGIVSTPVINHPEVAIVGVNRIVERPMVVGGNIVVRKMMNLSSSFDHRVVDGMDAAAFIQAVRGLLEHPATLFLE
What is the function of this protein?
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, Branched-chain alpha-keto acid dehydrogenase complex component E2, BCKAD-E2, BCKADE2, Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, Dihydrolipoamide branched chain transacylase, Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: HV124_HUMAN
Sequence: MDCTWRILFLVAAATGTHAQVQLVQSGAEVKKPGASVKVSCKVSGYTLTELSMHWVRQAPGKGLEWMGGFDPEDGETIYAQKFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCAT
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 1-24.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: GLMU_NITEC
Sequence: MLQIDVVILAAGMGKRMRSTLPKVLHPLAGKPILFHVLDTARILSPTKICVIYGHGGELVRQTVGNDPNLIWVKQTQQLGTGHAVKQALPCLGKNGITLVLFGDVPLVKSNTLKSLIDKACEDSLALLTVELNDPAGYGRIIRDPKTNRVQAIVEEQDALPSQKKIREINTGIMVLPNMYLESWLDRLSNANTQGEYYLTDIIAMAVNDGVQIETSSPASDWEVVGVNDKIQLSTLERAHQQDVAKGLMEQGVMFADPARFDVRGQLICGHNVEIDINCVFEGNVRLGDNVKISANCILRNVAISDGSIVHPFSMIEDTEVGKNCRVGPYARIRPGTQLDDAVHVGNFVEIKNSHIASGSKVNHLSYIGDTEMGRRVNIGAGTITCNYDGAFKHQTIIEDDVFIGSDSQLIAPITVAKGSTIGAGSTITRDTPEGQLTLSRIKQISIANWKRPKKNKD
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGMG2_BURCH
Sequence: MQPDLNPNTTQPLIALTGIGKRFPGVQALDDCRFDLRAGEVHALMGENGAGKSTLMKILAGVYQRDAGEIRMDGRPVEIADPRAAQALGIGIIHQELNLMNHLSVAQNIFIGREPRGRFGVFVDEEKLNRDAAAIFQRMRLDLDPRTPVGRLTVAKQQMVEIAKALSFDSRALIMDEPTAALNNAEIAELFRIIRDLRAHGVGIIYISHKMDELRQIADRVTVMRDGKYVATVPMADTSMESIISMMVGRQLDTETRTPPDTSGNEIALEVRGLSRGRAIRDVGFTLRRGEILGFAGLMGAGRTEVARAVFGADPVDAGEIRVHGRAVTIRTPADAVKYGIGYLSEDRKHFGLAIGMDVQNNIALSSMRRFVRRGLFLDARGMRDAARSYVRQLAIRTPSVAQPARLLSGGNQQKIVIAKWLLRDCDILFFDEPTRGIDVGAKSEIYKLLDALAADGKAIVMISSELPEVLRMSHRILVMCEGRVTGELRAADATQEKIMQLATQRESTVLS
What is the function of this protein?
Part of an ABC transporter complex involved in carbohydrate import.  Could be involved in ribose, galactose and/or methyl galactoside import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Putative ribose/galactose/methyl galactoside import ATP-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Carbohydrate importer 2 (CUT2) (TC 3.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MTHR_HUMAN
Sequence: MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMRRRLESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDPRRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYLSGEPNRNGHKVTCLPWNDEPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDFPLDNCLWQVVEDTLELLNRPTQNARETEAP
What is the function of this protein?
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine (PubMed:29891918).  Represents a key regulatory connection between the folate and methionine cycles (Probable).
What are the official names of this protein?
Methylenetetrahydrofolate reductase (NADPH).
What is the protein family that this protein belongs to?
Belongs to the methylenetetrahydrofolate reductase family.
Protein: S12A1_RABIT
Sequence: MSLNNSSSVFLDSVPTNTNRFQVNVINENHESCAAGIDNTDPPHYEETSFGDEQNRLRISFRPGNQECYDNFLQTGETTKTDASFHTYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVAVTPGSADRVANGEGMPGEEHAENKEEDNKAGAVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVVIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVGACVVRDATGSMNDTIISGINCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAAKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCFVLTGGPMTRPALLDITYAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKKWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELEKLEQERLALEATIKDNECEEGNGGIRGLFKKVGKLNITKPTPKKDSSINTIQSMHVGEFNQKLVEASTQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIAMASLLSKFRIKFADIHVIGDINIKPNKESWKFFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS
What is the function of this protein?
Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation.  Electrically silent transporter system.
What are the official names of this protein?
Solute carrier family 12 member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: PA2HG_TRIST
Sequence: MRTLWIMAVLLLGVEGSVIELGKMIFQETGKNPATSYGLYGCNCGPGGRRKPKDATDRCCYVHKCCYKKLTDCDPIKDRYSYSWVNKAIVCGEDNPCPKEMCECDKAVAICFRENLDTYDKKKKINLKLFCKKTSEQC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks catalytic activity (PubMed:12959640).  It shows myotoxic and weak anticoagulant activities and induces local edema a few hours after injection (5-10 ug) in the hind paw (PubMed:12959640).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog Ts-K49c, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: N42L1_MOUSE
Sequence: MEDSFLESFGRLSLQQRQQQPPPRPPPARGPPPRRHSFRKHLYLLRGLPGSGKTTLARQLQHDYPRALIFSTDDFFFKEDGTYEFNPNLLEEAHEWNQRRARKAMRNGISPIIIDNTNLHAWEMKPYAVMALENNYEVIFREPDTRWKFNVQELARRNIHGVPKEKIQRMKERYEHNVTFHSVLHAEKPSRANRNQGRNSEPSSGSGYWNTYTELPNRRANGLYSNEGYRRGGHHQGY
What are the official names of this protein?
NEDD4-binding protein 2-like 1.
Protein: COQ4_BOTFB
Sequence: MSLSPRLYTQVSRLPRELLTACSITLATRSFSVLHRPAPNYPGHVPLTSIERGGLAVGSAVMAFFNPYRADLIAACGEATATPYFIYRLRDAMLSSPTGRRILRDRPRISSKTLSMPRLRALPPNTVGRCYAEWLDREGVSPDTRDSVKYIDDEECAYVMQRYRECHDFYHAITGLPIVREGEVALKAFEFANTLLPMTGLSMFAVMSLKPAERRRFFTIYAPWAFANGLKAEEVINVYWEEQLERSVEELREELGIEKPLDLRDIRRMEKERKKAQKAT
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein coq4, mitochondrial, Coenzyme Q biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: FTSQ_CELJU
Sequence: MDSREDMVPDVLLEAPNPRRRQSADTSTERPTRPARREQGYARVTPRGERMGNHKARVAKPDFFAWFDPRWLWVPLMVCLAVGGYWAYEPLEKLLERPFKSVVVEGEFHFITKARATELISDEIDNNFLQLDLMRLKRTLTDDPWVDSVSLQRRWPDTLVVKIAEQKPIARWGDGFLNQRGQIVRVKEIDRLSGLPWLQGNESDAVEILQQYQDLSQLLRSRGLDVIALKCDNKKSWRLTLKNDVEIAIGRDKVMEKMRRFVTVYDTHLNSVWIDIAAIDVRYSNGLAVRWVEGSESAKKYLRAAAATTNATRNAPTHP
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.  May control correct divisome assembly.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: PSP3_SCHPO
Sequence: MRVSWISGLLLVAHLAPSSAFNPLRFFLDDTFSSGATEEHFMGPSDDGFALQQPTNYDPSMPFPLDESASAAVDAVSNNYIVMFKPSVDKSKLEQHHRWIEHLHEKRSLDFKDVSTFLMKHTFEIGDAFLGYAGRFSPWLVAELQKHPDIALVEPDRVMHVMTEQTFAPWGLARVSHRKKLGFFTMTRYQYNETAGEGVTAYVIDTGINIEHQDFQGRATWGATIPTGEGEVDDHGHGTHVAGTIAGKTFGVSKNAKLVAVKVMRADGTGTVSDIIKGIEFAFKQSKKDKESIASVVNMSIGGDASTALDLAVNAAIAGGLFFAVAAGNDAEDACGTSPARVSNAMTVGASTWNDQIASFSNIGSCVDIFAPGSLILSDWIGSNRASMILSGTSMASPHVAGLAAYFISLDPSLANHPVELKKYMLKFALKDLLNGIPEDTPNVLAFNNYE
What are the official names of this protein?
Subtilase-type proteinase psp3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
Protein: RL31_HELPJ
Sequence: MKKGIHPEYIPCKVTCVTSGKEIEVLSTKPEMRIDISSFCHPFYTGSDKIADTAGRVEKFKQRYNLK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RL3_BRUSI
Sequence: MRSGVIAQKLGMTRVYNDAGEHVPVTVLRMENCHVVAQRTVEKNGYTAVQLGVGMAKVKNTSKAMRGHFAKAEVEPKAKLAEFRVSPDNLLEVGVEITAEHFVAGQKVDVTGTSIGKGFAGVMKRHNFGGHRASHGNSITHRSHGSTGQRQDPGKVFKGKKMAGHMGQTRVTTQNIEVVSTDSDRGLILVRGAVPGSKGAWILVRDAVKASLPENAPKPAGLRAGAKAEAAATEGAE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: F110A_MOUSE
Sequence: MPVDTLSPGAPATPALPFRLRTKVPGYLLPRPADGGARKPSAVERLEADKAKYVKSLRVANTRQEPVQPPLVRQPLFSPGPRGPVLTPSRRVLPCSGRRPQLDLDILSSLINLCDSPVSPSEASRTPGRPEGSAHKVPPATPPRPPPSTVAVRRVDVRPLPASPARPYPSPGTTTTSSPGRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPCSSEGGCSRRSSATVEERSLDRVPYGVSVIERNARVIKWLYGLRQARDPPTTEG
What are the official names of this protein?
Protein FAM110A.
What is the protein family that this protein belongs to?
Belongs to the FAM110 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles.
Protein: TIPRL_XENLA
Sequence: MMIHGFKSSNQEFNFGPWQLTAIKTHIMKSADVEKLAEEMSMPCLPEMMFGENVLRIQHTSGFGIEFNANDALKVVKNSQGSVKVACAEEWQESRSDSEHSKEVVKPYDWTYTTDYKGTLLGDNMKLNVVPTTERINTEKLKAKEQIMFFEEVLLFEDELHDHGVSSLSVKIRVMPTSFFLLLRFFLRVDGVLIRMNDTRLYHEADKTFMLREYTSKESKISNLSHVPPPLYTEPNEISQYLPVIQTIYEKLEFPSQPH
What is the function of this protein?
May be a regulator of serine/threonine-protein phosphatases 2A (PP2A) and 4 (PP4).
What are the official names of this protein?
TIP41-like protein.
What is the protein family that this protein belongs to?
Belongs to the TIP41 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THI4_METM6
Sequence: MDGKLRADEVAVTKSILKSTFNMWMDIIDVDVVIVGAGPSGLTAAKYLAQKGFKTVVLERHLSFGGGTWGGGMGFPNIVVEKPADDILREAGIKLDEVDGEEELFTADSVEVPAKLGVAAIDAGAKILTGIVVEDLILKEDKIAGVVIQSYAIEKAGLHIDPLTISAKYVIDSTGHDASAVHTLARKNKDLGIEVPGEKSMWAEKGENSLTRNTREIFPGLYVCGMAANAYHAGYRMGAIFGGMYLSGKKCAEMILEKMEK
What is the function of this protein?
Involved in the biosynthesis of the thiazole moiety of thiamine.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
What are the official names of this protein?
Thiamine thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
Protein: YOBH_ECOL5
Sequence: MRFIIRTVMLIALVWIGLLLSGYGVLIGSKENAAGLGLQCTYLTARGTSTVQYLHTKSGFLGITDCPLLRKSNIVVDNG
What are the official names of this protein?
Uncharacterized protein YobH.