PharMolix/UniProtQA huggingface dataset:
Protein: RPOE_STRSY
Sequence: MELNVFAGQEKSELSMIEVARAILEERGRDNEMYFNDLVNEIQNYLEKSNSEIRAALPTFYSDLNVDGSFIPLGENKWGLRSWYAIDEIDEEVITLEEDDEDAPKRKKKRVNAFMDGDDDAIDYGHDDPEDEDNYPGSVSSEYDDENPDDEKDEVESYDSEINEIIPDDELDEEDVDLGEDDDEYSDEEVVDE
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: RL25_RICTY
Sequence: MSEILELEAKSRTEFGTGAARALRREGRVPAIIYGAGKIPISISLEEKEITKYYRRPAFISQLINLTIDKKQYKVLPKAVELHPVTDIVRHVDFVFLEAKTQKMEVPVVYEGKERALGVKRGGYFNIIKRRVILLCDINNIPRNVTIDVTNMPIGTSLKSSEVKLPIGCSFVTKKEFVLATIIGRKGVKTEIEGEQQVAGAMQ
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RTL6_MOUSE
Sequence: MVQPRTSKTESPASAPGASAQMDDVVDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAITSNGTRPMTTPPTSLPEPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHSRRAQIRKTSASNRAVRERERERQMLCRQLAAAGTGSCPVHPASNGTNPAPALPSRGRNL
What are the official names of this protein?
Retrotransposon Gag-like protein 6, Mammalian retrotransposon-derived protein 6, Protein LDOC1L, Protein Sushi-15E3.
What is the protein family that this protein belongs to?
Belongs to the LDOC1 family.
Protein: M2_I00A0
Sequence: MSLLTEVETPTRNEWECRCSGSSDPLVVAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: AC4CH_VIBVY
Sequence: MTAPTKMTFFSRFEADILAGKKTITIRDESEKDYQPGTTVEVSTLEEGRVFCQLKILSVEPIAFSELNEFHAEQENMTLATLKEVIQEIYPGIEQLYVIQYQRV
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: RL20_AZOSB
Sequence: MPRVKRGVTARARHKKVLDQAKGYRGRRKNVYRIAKQAVMKAGQYAYRDRRQRKRQFRALWIARINAAARELGLTYSTFMNGLKKAAVEVDRKVLADLAVFDKPAFAALAEQARAKLAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PDAD_PYRHO
Sequence: MTWITPKKAIMLAAAAEGGTKLNAFDNALLKMGIGNVNLVKLSSVIPAHIEWLDELPKNIPIGMLLPTVYAHIESDEPGSTISAALGVGISEGNEGGLIYEYAGYCKREEAEDMVRKMVEEGFKVRGWKLKEFKVVSAEITVKEKPAAAVAAVIMFPY
What are the official names of this protein?
Pyruvoyl-dependent arginine decarboxylase, PvlArgDC.
What is the protein family that this protein belongs to?
Belongs to the PdaD family.
Protein: KTHY_THET8
Sequence: MPGLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLLLTQELSPEAEYLLFSADRAEHVRKVILPGLAAGKVVISDRYLDSSLAYQGYGRGLPLPWLREVAREATRGLKPRLTFLLDLPPEAALRRVRRPDRLEGLGLEFFRRVREGYLALARAEPGRFVVLDATLPEEEIARAIQAHLRPLLP
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: YMDE_ECOLI
Sequence: MEDGVQAMRDYLAGLDIASPEHQVLMNVTAKSEVAPSIIKENLSLHLTHTVKWTESLDTFLNMPTPVAFLEISNKPYLGNMLNDFAGVDQQRVMHCRKAFSDAKVFK
What are the official names of this protein?
Putative uncharacterized protein YmdE.
Protein: F236B_HUMAN
Sequence: MIFTPFLPPADLSVFQNVKGLQNDPEEWVAVSDATEDPSGGTGLPREPALLRGSWRSRFQRALACFTKCFRGGYRALGI
What are the official names of this protein?
Protein FAM236B.
What is the protein family that this protein belongs to?
Belongs to the FAM236 family.
Protein: CPRM_PINNO
Sequence: ITIEQGELVLNCISDKMMCEFEAAAEMVVPSPCPSEYDTCILETNIPPANQXPVHXIPXMH
What are the official names of this protein?
Calprismin.
Protein: ARGJ_SYMTH
Sequence: MEWLAGGVTAPAGFVAAGACADIKGNGAGKKDVALLASRVPCAAAGVYTTNLVKAAPVVLTRGRTETGELQAVVANSGNANACTGEQGMRDAAEMARLAAEALGIRPELMGVASTGVIGVPLPMDRVSAGIRAAAAALSPEGGADAAEAIMTTDTFPKQAAARLEIGGATVTIGAMAKGSGMIHPNMATMLGFVTTDAAVDAAALREALREATDRSFNMITVDGDTSTNDMVLVLANGLAGNPRIMPGSAHYRAFADALAAVLIHLAKEIARDGEGATKLIEVRVKGAATLSDARKAARAVCGSNLVKAAVFGEDANWGRVLAALGYSGAQFDPGRVDLWLGDLQMMRAGEPVAFDEAAAARVLREKEVVFTADLHAGECEATAWGCDLTYDYVKINGSYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS181_MYCGI
Sequence: MAKSSSTKRRPAPEKPVKTRKCVFCSKKGKNQVIDYKDTQLLRTYISERGKIRARRVTGNCVQHQRDIAIAVKNAREVALLPFSSSTR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: O16EB_CONEA
Sequence: VLIIAVLFLTACQLTTAETYSRGRQKHRARRSTDRNSKWTRECTDSGGACNSHDQCCNEFCSTATRTCI
What are the official names of this protein?
Conotoxin Eb6.14.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HTPX_LEPIN
Sequence: MWFKRIGLFLLTNILVVVTISIVTSVLGIGPYLDANGINLSSLLVFCFLWGMGGAFVSLLLSKFMAKMMMGVQVIDPRSASGAERELYSRVERLARTANLPMPEVGIYHSPEVNAFATGPSKSSSLVAVSSGLLQTMDNAEVEGVLAHELAHVANGDMVTMTLIQGVVNAFVMFFSRIISYALSTMVKDELQYTVRLIANIVLSILFSILGSIIVAYFSRTREYRADAGGAKLAGRQNMIAALEKLKRTFDAPEDERGREALATMKISGHNKWMALFSTHPPLEARIAALKNSGY
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NIR_CERS5
Sequence: MFTRRAALVGAAALASAPLVIRTAGAEEAPAQLASAAPVDLSNLPRVKHTLVPPPFAHAHEQVAASGPVINEFEMRIIEKEVQLDEDAYLQAMTFDGSIPGPLMIVHEGDYVELTLINPPENTMPHNIDFHAATGALGGGGLTLINPGEKVVLRFKATRAGAFVYHCAPGGPMIPWHVVSGMAGCIMVLPRDGLKDHEGKPVRYDTVYYIGESDHYIPKDEDGTYMRFSDPSEGYEDMVAVMDTLIPSHIVFNGAVGALTGEGALKAKVGDNVLFVHSQPNRDSRPHLIGGHGDLVWETGKFHNAPERDLETWFIRGGSAGAALYKFLQPGVYAYVNHNLIEAVHKGATAHVLVEGEWDNDLMEQVVAPVGLTG
What are the official names of this protein?
Copper-containing nitrite reductase, Cu-NIR.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: URE2_ALBFT
Sequence: MIPGELFTDGPEHVLNPGRRAHTLAVVNASDRPIQVGSHYHFAETNGALGFDRAAAKGMRLNIASGSAVRLEPGQQRTVELVDYAGDRIVYGFRGLTQGAL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_FRATN
Sequence: MKANHIRILLLVTIAIMFISLMGKWEQTFPADNTKQQTSATQNNSHYDNADSSTNTDVTTTDAKSSLAKETNFSKYDNAKSITINTGVFKDVKVSLLDGAIISASLKDYSISLDDKTPMSLLTDKSGSEYIAKSTIVVNKQPISVNFEDQGIKTENGKQILTLTGSADGLQITRTYTFDDTKYNISVSQNIKNTTSAPVNVIVDDSFARDFDPAGDSFSLLNAHSYTFTGVAYSTAKDSFRKESFKDISKTNGQPTVINSDGQGWVAFLQHYFVSAWIPQSTNAKIYYKNLNGDVFEAGAFTGATIAPNQSENISSILYTGPIIKANLVDLAPNLEKTLDYGMLSFFSEIIFWVMNHIHSLVGNWGLAIILVTCLIKLIFYPLSAKSYRSMAKMRMLQPRIKRLQETYKDDRQALGKKMMELYKEEKVNPLSGCLPMLIQIPIFISLYWVLLESVELRQAPFIFWIHDLSMKDPYFVLPVLMGLSMFLQQKLSPAPADPMQAKVMMFLPVIFTFLFASFPSGLVLYWLTNNLISISQQWIITRHYQATHKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y343_MYCGE
Sequence: MSHKINDQTLVNEQRLLAYDFFQNSNKVGLLSTLQYLDFVNFLVRSKKVNYLLVNKVSLPIYQKIYFDNFPFLGFDNNLWSAFGLALRNKSQNDTVFAFVEKTKNTDTEINKFLKILKTFKGLKIVFLLINSPEEKTTIKLSDSLIKEIKKQKIKHEVYSLRSFQNKFFKLVRKLEKKHKSKNNVMFVELNGVFGYETNFEKSNIDFSFTSFQDRFTIEKKLKITSHFILPHKYLLKNLENIKHPNFEQKNLIWQQTVKDFNQQFLLHYSKLQVFSNSPTKLKVDALIFDLEFHLIVEIMKGFNFDENCICLLEGNKEQNPNLPTVSLDTKVADIKTYQGCYFLNN
What are the official names of this protein?
Uncharacterized protein MG343.
Protein: MOBDB_HALVD
Sequence: MNPDSAAGRSSRRAFLAAVGGVAAGGLTATAGCLGRGEEAPTVSILAAGSLQRALTTEFDAPDGTRIEVEAHGSARVARMVDDDQRDPDIVALADPALFDAPLSVPWYATFANNALVVAYNPQTEGGTRVTEAASWPDALLDDAVSLGRTDPDLDPLGYRTRFALALAADHYDRPALTADLLRRDQIYPETQLLAQFDAGGVDAAFVYRSMAVERDYPYLELPAAINLSDPDHASAYATVSYTLPDGVTVRGGPIRYAATRRTDTAAAKSVFEALVGTAGDFLEPSGFTVRASHPHYFGDVPPTA
What is the function of this protein?
Part of an ABC transporter complex involved in molybdenum import.
What are the official names of this protein?
Putative ABC transporter molybdenum-binding protein HVO_B0369.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.
Protein: RDRP_PMV
Sequence: MANLRSVFEQLNDVSLRAVIQEEAYRDIKLTIKETKTYNPYAHPVAVADSLEKLGIETNPFAVKAHTHAAAKTIELDMYKIVSFYLPKENPTTFMFMKRSKLQYFRRGPQQKDVFLNAHIEPKDVARYDVDTLFDKNVTPQITTNTAFMGDTLHFLPLTAIERIFKSSPKLQTLYATMVLPPEALHRLHSLHPGIYELEFHQEHFIYKPGGHAGAAYIHKYEQLEWIKVGRFKWADEKGLTHMVTSQILETKGANHLFIFQRGRFLTPELRCFSTETKYVTMPPIFLPKQFNARLPIKKTTAQQLFLYVKSVKNVTERDIWAKMRQLLKTSELQDYNPREVTLLVNYFLLIARLRSETCFDNVLSGGMFKKLFKPFIAWWEIQKHKIFGNEEFEQLMEALEWVDVTLTYPTKTFDNRGWVVKLEARRGYEWFADEMHKPKGPELNLEEKKTDPDAASYEKYLKALSLLQKEPEVMEAKEAEATDEPQRPEVKEEQAEASTSGRAEEIQEDPATKKGKEEPNPNRDLLCPCGLHLKIKNAEFPELPVLDHPDHLTGRKAWFFSKDGKPYSYTGGSHASRGWPNWLEKILAAIEIKEPLPEFNQCLVQQFKLQAAIPFHRDDEPCYPKGHQVLTINHSGECLTQIACQKGKASITMGFGDYYLSPVGFQESHKHAVSNTTGGRVSLTFRCTVQQNKFNDDGSMEALDNLPWKAWIPKLQNLGFQGRQLQYDPNGALISPIEEIRSMPKCKPEGVPEVVYKTLDGLARAPTPYSPNPIRARAYTSDVKNCRIGALLRQQGKEWGCRFDALVEAGKRELAISVIHGAGGSGKSQALQTLIKDNPELDITVVLPTNELRLDWLRKLPKAPQEKFKTFEKALLAPPTPIVIFDDYGKLPAGYVEAFCLYFSTVQLIILTGDCKQSVHHESNENATTSSIEPLVKEASELCRYYINATHRNKKDLANKLGVYSEKTGLTEVTHGTTPIPGLHMLVPSLYKKQAFSEMGHKVSTYAGCQGITAPKIQILLTEETSLCSREVLYTALSRAVHSIHFVNASPNNQAFWKKLECTPYLKAFLSTLREEVAQPIEEKKAEPTPVEPPRTHIAKEDAMVEYENVIEKMPEKHEREIFSEKHGHSNCVQTEDPFIQMFSHQQAKDDTLLWATIEARLVISNPKANWQEYLEKRPVGEVLFESYKRAMHLPKMPIPFEEDLWNSSMHEVQKTYLSKPENMIKNGMARQSPDYDPNVISLFLKSQWVKKMEKLGAIKIKPGQTIASFHQATVMLFGTMARYMRRMREVFQPAHIRINCEMTPEDLSSWAAGEGGHWKFKGPSLANDFTAFDQSQDGAMLQFEILKARHHSIPEDILDAYLTIKTNSKIFLGTLAIMRLTGEGPTFDANTECNIAFTHTKFNIPEGTAQLYAGDDSAIDGLPALRPSFKMIEQKLTLRSKPQVALQQKGDWAEFCGFRITPKGLIKDPKKLHASWMLEKKKGNVKNVLRSYELDLALAYQHKDSLHELLSEEELKYHYETVRSIVKSGGGGVLNTYISKDESLY
What is the function of this protein?
RNA replication.  The central part of this protein possibly functions as an ATP-binding helicase (Probable).
What are the official names of this protein?
RNA replication protein, 176 kDa protein, ORF1 protein.
What is the protein family that this protein belongs to?
Belongs to the potexvirus/carlavirus RNA replication protein family.
Protein: THIE_ARTS2
Sequence: MTEQALLTDARLYLCTDARTDRGDFADFVDAAYAGGVDIIQLRDKGLEAAEELELLEVLETAARRHGRLWSVNDRADIASLSGAPVLHVGQKDLPLASARKFLGGEAVIGLSTHSHGQIDAAIAASRGAGGLDYFCVGPVWATPTKPGRAAVGLELVRYAAEAAGKTTAKTTGGAAGPTVDGPRLPWFAIGGIDLGNVEQVAAAGAERIVVVRAITEADDPAAAARSLLAALDAGAS
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RL2_BRADU
Sequence: MALKTFNPTTPGQRQLVMVDRSALYKGKPVKALTEGKHSSGGRNNTGRITVRFRGGGHKQTLRIVDFKRDKVDAPATVERLEYDPNRTAFIALVKYEDGTQAYILAPQRLAVGDSVVAGNYVDVKPGNVMPLGNMPVGTIIHNIEVKIGKGGQLARSAGTYAQLVGRDQDYVIIRLNSGEQRLVHGRCRGTIGAVSNPDHMNTSIGKAGRNRWLGRKPHNRGVSMNPIDHPHGGGEGRTSGGRHPVTPWGKPTKGKKTRSNKSTNKFILLSRHKRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: LSD90_SCHPO
Sequence: MVGTINESMQNMKIGAKETAQSAKQGIKNAGQSSSKTARDVMGNPVPGSYTAGNTANDGDSSYASSKNPSGNADIGATSSERTAYAAPQRAAVDTSNVSPPSTQTGGYASKDTTSTYEGAQPLSSQSSRSSNYTNVKITATQNNVDALTGAPIRIVTTTNARIQPDEKTLQDLLEQRQVALREAREAEEELQRARQYNDRSTSEALELEARAKKAAQDAELASERAREAQSSIERSASLREKQAREEAERAATALREAELKHRLAQANADVDVANSKLDIALKNEAAWKAERESSLAHQKAVIDSARAELERARHEAAVADATYKKEHYEYNALVAELEERNDNTLRTASIREAEARNLEVHMEDTLKDARMRSRNATEQVEVVKREINSEIDVYRSSVEKTKAELASYQKGLPSQKEACDRELDDATRALQAAQDRFNAAKLRVNQFDVDSRQQLAMLTKKVRDAEDAEEKYRISCHQREEEITRCATQAYDAVKAAEKRNETIAEAARAKENEAKDLYSKAESITQDLNAKRSHPPQPANLDYSSAIQRAQERLTLEESKLTDLRTAEPSQYVNDVEVARRALRDAQAEQSKVESEYNSVKGSKLYTTEPVHPHAVTTNEPTDVSTKSKSAAYHYPATTETVSSKAARSATTPAYVGGATKTPSTTKAVESTPSTLPTSASTNAAATTTTKKPKAAKSTAVRDDVSSASSDSDKGTTGLGKSESKSSRKERRSSTSSGHGLMNNVRHALGMSNK
What is the function of this protein?
May be involved in the metabolism of very long-chain fatty acid-containing phospholipids (VLCFA-PL).
What are the official names of this protein?
Protein lsd90, 90kDa large and small daughter protein.
What are the subcellular locations of this protein?
Note=Localizes to small particle-like structures, that differ from either the mitochondria, the endoplasmic reticulum near the nucleus, or the peroxisomes.
Protein: P3H1_MOUSE
Sequence: MAVSERRLLAAMLAVAAAAALRVAAESEPGWDVAAPDLLYAEGTAAYSRGDWPGVVLNMERALRSRAALRALRLRCRTRCATELPWAPDLDLGPDPSLSQDPGAAALHDLRFFGAVLRRAACLRRCLGPPSAHLLSEELDLEFNKRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMRQNLDYYQTMSGVKEADFRDLEAKPHMHEFRLGVRLYSEEKPQEAVPHLEAALQEYFVADEECRALCEGPYDYDGYNYLDYSADLFQAITDHYVQVLNCKQNCVTELASHPSREKPFEDFLPSHYNYLQFAYYNIGNYTQAIECAKTYLLFFPNDEVMHQNLAYYTAMLGEEEASSISPRENAEEYRRRSLLEKELLFFAYDIFGIPFVDPDSWTPEEVIPKRLQEKQKSERETAVRISQEIGNLMKEIETLVEEKTKESLDVSRLTREGGPLLYEGISLTMNSKVLNGSQRVVMDGVISDDECQELQRLTNAAATSGDGYRGQTSPHTPNEKFYGVTVLKALKLGQEGKVPLQSARMYYNVTEKVRRVMESYFRLDTPLYFSYSHLVCRTAIEESQAERKDSSHPVHVDNCILNAEALMCIKEPPAYTFRDYSAILYLNGDFDGGNFYFTELDAKTVTAEVQPQCGRAVGFSSGTENPHGVKAVTRGQRCAIALWFTLDPRHSERDRVQADDLVKMLFSPEEVDLPQEQPLPDQQGSPEPGEESLSDRGSLHKDEL
What is the function of this protein?
Basement membrane-associated chondroitin sulfate proteoglycan (CSPG).  Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V.  May be involved in the secretory pathway of cells.  Has growth suppressive activity in fibroblasts (By similarity).
What are the official names of this protein?
Prolyl 3-hydroxylase 1, Growth suppressor 1, Leucine- and proline-enriched proteoglycan 1, Leprecan-1.
What is the protein family that this protein belongs to?
Belongs to the leprecan family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Secreted, extracellular space, extracellular matrix. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG).
Protein: SECA_RICRO
Sequence: MLSILKKLFGTANDRTVKKLFSEITKINSLEPAIQKLSDEELKNKTVEFKEKLKNGATLDDIVYEAFAVVREAAKRVCGMRHFDVQLIGGLILHRGMITEMRTGEGKTLVATLPAYLNALTGKGVHVVTVNDYLARRDSAAMGKIYNFLGLSVGCIVGGMPDEVKRAAYNADITHATNNELGFDYLRDNMKYSLQERVLRPFNFAIIDEVDSILIDEARTPLVISGPVNDNAELYGKIDKIVRLLNASDFEKDEKLKTINLTETGITHIESLLSKENIIKPDTSLYDFENLTLVHYINQALRAHNMFTVNVDYLVREGKVMIIDEFTGRVMEGRRYSEGLHQALEAKENVKIQNENQTLASITFQNYFRNYPKLSGMTGTAMTEAPELKDIYNLDVVAVPTHNKVTRLDLDDEIYGSKKEKYDAILKLIRDCYDRGQPILVGTISIEKSEELSSVLNKENIPHKVLNAKFHEQEAFIIAQAGRFKAVTIATNMAGRGTDIMLGGNPEMLIEQLDKEHNYEAKIAEIKAQIAEEKKQVIEAGGLFVIGTERHESRRIDNQLRGRSGRQGDPGKTKFFLSLDDDLMRIFASDRISGVLRTLGLKDGEAIHHPMISRSLEKAQQKVEGHNYEMRKNLLRFDDVMNDQRKIIYEQRTEIIKSKDSHGFLNSTTEELAKKIVLTFMPVGSYREDWDIENLSVELHRVFSIKFDHNVVSKNDVTEEEITKTVIQMAHDIYKSKEEAYSSELMHNAVKYILLTTLDQVWKDHLYSLDHLRQGISLRAYGQKDPLSEYKREAFNLFEQMLNNLKELFIQTVYHFHIDLKNVQKEDVSLEYKKLQKNMCESREDPAFSKYNAGSSLETDLKPVVSRIDPKDRNPDDPTSWGRVSRNELCPCGSGKKYKYCHGANE
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PITH1_DANRE
Sequence: MSGHGHGHGHGHGCCECEHEPAERGVEYELYRRIDIEKLQCLNESRDGDGKLVFKPWDQRTDRNKFVESDADEELLFNIPFTGSVKLKGIIISGEDDESHPAEIRLFKNIPQMSFDDTSREPEQAFRLNRDPRAELEYPTKIARFSNVEHLSIHVSRNFGAESTRVYYIGLRGEYTEAHRHEVTICNYEAAANPADHKVESITPQTQFIS
What is the function of this protein?
May play a role in promoting megakaryocyte differentiation by up-regulating RUNX1 expression.
What are the official names of this protein?
PITH domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PITHD1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_GEOTN
Sequence: MTGRLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEGLREMFKEISPIEDFSGNLSLEFIDYSLGEPKYSVEEAKERDVTYAAPLRVKVRLINKETGEVKEQDVFMGDFPLMTETGTFIINGAERVIVSQLVRSPSVYYSDKVDKNGKRGYSATVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFSSDQEIIDLLGDNEYLRNTLEKDNTDSTEKALIEIYERLRPGEPPTLENAKSLLASRFFDPKRYDLASVGRYKINKKLHIKNRLFNQRLAETIADPETGEIIAEAGTMIDRRTLNRLLPYLEKGAGLQTYRPTEGVADGQISVQTVKIYAPNDPDNEKVINIIGNGFIAEDVKHITPADIIASISYFFNLLHGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDANTITPQQLINIRPVIAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHYSHYGRMCPIETPEGPNIGLINSLSTYAKVNKFGFIETPYRRVDPETGKVTDQIDYLTADEEDNYVVAQANVPLAEDGTFLEENVIARFRGENIVVKRDRVDYMDVSPKQVVSAATACIPFLENDDSNRALMGANMQRQAVPLLQPEAPIVGTGMEYVSAKDSGAAIICKHRGIVERVEAKEIWVRRLIEVDGKEVKGDLDKYRLLKFVRSNQGTCYNQRPIVKKGDIVEKGEILADGPSMDKGELALGRNVLVAFMTWDGYNYEDAIIMSERLVKEDVYTSIHIEEYEAESRDTKLGPEEITRDIPNVGEDALKNLDERGIVRIGAEVKDGDLLVGKVTPKGMTELTAEERLLHAIFGEKAREVRDTSLRVPHGGGGIVLDVKVFNREDGDELPPGVNQLVRVYIVQKRKISEGDKMAGRHGNKGVISRILPEEDMPFLPDGTPIDIMLNPLGVPSRMNIGQVFELHLGMAAKKLGLHIASPVFDGATEEDVWNILEEAGMARDAKTVLYDGRTGEPFDNRVSVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTVKSDDVVGRVKTYEAIVKGENIPEPGVPESFKVLIKELQSLGMDVTILTSDEQEINMENFDDDDDHAPDAIMVDVKPVESEEADEEKNAVTKE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: YCIB_VIBC3
Sequence: MKQLLDFIPLIIFFALYKFYDIYVATGALIAATTLQVIVTYAMYKKVEKMQLITFVMVALFGGMTLALHDDNFIKWKVTIVYVVFALGLTISQIMGKPAIKGMLGKELTLPDAVWSTINWAWVMFFSGCAALNLYVAYHLPLDVWVNFKVFGLLAATFVFTLLTGGYIYKHLPHEPKQKNQ
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIPA_FRATF
Sequence: MKEISGIKVKVESGSKYTTDHGFYAVKDGIRNKKENAVHVRKPDWLKVQKQDSKEYLKVKSITKKHKLSTVCEEARCPNINECWSHGTATIMLMGSVCTRACKFCSVDTGNPKGWLDKDEPMNAAESVKLMGLEYVVLTSVDRDDLEDGGAGHYAATITAIKNLDENIKVEALTPDFAGINENIDKIINTKVDVIAQNIETVERLTHPVRDPRAGYWQTLNFLKYVKQKSPNVLTKTSIMVGLGETDEEIYKTMDDARSVGVDIITLGQYMQPTKHHLSVERFVTPQQFEEYRKVGLEKGFLEVASGPMVRSSYRADRVFKRNNLDL
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.