PharMolix/UniProtQA huggingface dataset:
Protein: K1C25_CAPHI
Sequence: MSLRLPSGSRRASPRPTTGSLRLSGAGASFGAGNACSMPGIGSSFSCAFGSSSSGGNALGGNPCAGFTMNEGGLLSGNEKVTMQNLNDRLASYLENVRALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIEDLKNQIIASTTSNANAVLQIDNARLTADDFRLKYENELALHQSVESDVNGLRRVLDEITLCRTDLEIQYETLSEELTYLKKNHKEEMQVLQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQITEDVGATTSARNELTEMKRNLQTLEIELQSLLATKHSLECSLTETEGNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCLLIGGDDGACKSGGYKSKDYAAGNMGNQMKDPIKAIVVKKVLEEVDQRSKILTTRLHSLEEKSQSN
What is the function of this protein?
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity).  Plays a role in the cytoskeleton organization (By similarity).
What are the official names of this protein?
Keratin, type I cytoskeletal 25, Cytokeratin-25, CK-25, Keratin-25, K25, Type I inner root sheath-specific keratin-K25irs1, Type I keratin intermediate filament IRSa1.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_CMVKI
Sequence: MDKSGSPNASRTSRRRRPRRGSRSASGADAGLRALTQQMLKLNKTLAIGRPTLNHPTFVGSESCKPGYTFTSITLKPPEIEKGSYFGRRLSLPDSVTDYDKKLVSRIQIRINPLPKFDSTVWVTVRKVPSSSDLSVAAISAMFGDGNSPVLVYQYAASGVQANNKLLYDLSEMRADIGDMRKYAVLVYSKDDNLEKDEIVLHVDVEHQRIPISRMLPT
What is the function of this protein?
Capsid protein.  Probably binds RNA and plays a role in packaging (By similarity).
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the cucumovirus capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: M2_I43A0
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRLFKHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: RS7_ALKOO
Sequence: MPRKGSVPKREVLPDPIYGSKVISKLINGIMLDGKKGVAQKIVYDALALINERTGEDALEVFEKAMNNIMPVLEVKARRVGGANYQVPVEVRSDRRQTLGIRWLVNYTRARGEKGMVEKLAKEIIDASNSTGATVKKKEDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Y4SL_SINFN
Sequence: MGVRFSWGTEVRKLDVEGDKVRGVVTNWERLAADAVVVALGSYSPLLLKRHGIKLPVYPVKGYSLTIPITDASRAPESTIMDETYKIAITRLGDRIRVGGMAEISGYTNDLGPARRRTLEHSVMDLFPGGDAKEASYWSGLRPMTPDGTPVIGPTKIAGLFLNTGHGTLGWTMSSGSARVIADLVSGRKPEIDATDLAVSRYA
What is the function of this protein?
Either a functional dehydrogenase or a non-functional fragment.
What are the official names of this protein?
Uncharacterized oxidoreductase y4sL.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: ILVH_BUCBP
Sequence: MKHRILSILLENESGALSRVVGLFSQRGYNIESITVAPTEDLSISKITIQTFGDKKVIEQIGKQLHKLIDVLKVTEIEDEEHFKREIMLIKINNTYDQYRKVQDITNAFRGYIISATSNISIIQLSGTNKNLDTYIEIMKKLTNIIEISRSGIISIYKN
What are the official names of this protein?
Acetolactate synthase small subunit, Acetohydroxy-acid synthase small subunit, AHAS, ALS.
What is the protein family that this protein belongs to?
Belongs to the acetolactate synthase small subunit family.
Protein: SURE_BEII9
Sequence: MRILITNDDGINAPGLAVLERIASALSDDVFVVAPESDQSGVAHSLSLSDPLRLRKISDRRFAVKGTPTDCVIMGVRSILIEQKPDLVLSGVNCGQNLAEDVIYSGTVAGAMEGTILGIPSIALSQCYEAGTGGRSGIAWDCAEVHAPGIIKHLLETGIDPDVVINLNFPACPASEVTGLAVTAQGRRDATTIKIDPRQDGRGLPYYWIAFARDTRQPGVGTDLEAVAQKRIALTPLRIDLTDDPTMTRLAQSLPKTLPKVAG
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DJLA_YERPE
Sequence: MRYWGKLLGLVLGVMYAPGVVGALLGLLVGHMVDRALGAKRRGFFADQQTRQSLFFRTTFQVMGHLTKAKGRVTEVDIQLASQLMDRMQLHGAARTAAQQAFREGKESHFPLRKALQEFRRVCFGRFDLIRIFLEIQLQAAFADGSLHPNERQVLYVIAEELGISRGQFDQFLRMFDGGRQFGGHGGWQGQQGGYSQSGYQRASQGPTLEDACKVLGVNSSDDSVAIKRAYRKLMGEHHPDKLVAKGLPPEMMEMAKQKAQEIQAAYDLIKREKGFK
What is the function of this protein?
Regulatory DnaK co-chaperone.  Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway.  The colanic acid capsule may help the bacterium survive conditions outside the host.
What are the official names of this protein?
Co-chaperone protein DjlA.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type III membrane protein.
Protein: ACCO3_PETHY
Sequence: MENFPIINLEKLNGSERDATMEMIKDACENWGFFELVNHGIPHEVMDTVEKLTKGHYKKCMEQRFKELVASKGLEAVQAEVTDLDWESTFFLRHLPVSNISEVPDLDDEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKKAFYGSKGPNFGTKVSNYPPCPKPDLIKGLRAHTDAGGIILLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVLHRVIAQTDGTRMSLASFYNPGSDAVIYPAPTLVEKEADQECKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAREADVKSDPIATA
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate oxidase 3, ACC oxidase 3, Ethylene-forming enzyme, EFE.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: ARNA_ECOSM
Sequence: MKTVVFAYHDMGCLGIEALLAAGYEISAIFTHTDNPGEKAFYGSVARLAAERGIPVYAPDDVNHPLWVERIAQLSPDVIFSFYYRHLIHDKILQLAPAGAFNLHGSLLPKYRGRAPLNWVLVNGETETGVTLHRMVKRADAGAIVAQLRIAIAPDDIAITLHHKLCHAARQLLEQTLPAIKDGNILEIAQCENEATCFGRRTPEDSFLEWHKSAAVLHNMVRAVADPWPGAFSYVGNQKFTVWSSRVHSHAPAAQPGSVISVAPLLIACGDGALEIVTGQAGGGITMQGSQLAQTLGLVQGSRLNSQPACAARRRTRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHPHFHFVEGDISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYRKRIIFPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKEGLQFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIDGGKQKRCFTDIRDGIEALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHYFPPFAGFRVVESSSYYGKGYQDVEHRKPSIRNARRCLDWEPKIDMQETIDETLDFFLRTVDLTDKPS
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Protein: RL14_TROWT
Sequence: MIQQESRLKVADNTGAKSLSVIRVLGGSNRRFGSLGDVVVASVKDAVPGSSAVKKGDVVKAVIVRSTKEVRRTDGSYIRFDDNAAVILRPDNDPRGTRIFGPVARELRDRKFTRIISLAPEVV
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SYD_LISW6
Sequence: MEKRTNYCGELNETHIDQHVVLHGWVQKRRDLGGLIFIDLRDREGIVQVVFNPEFSKEALEIADSVRNEFVVTIKGKVHARGEKAINEKLATGKVEILAEEITILNTSKTPPFYIEDGVNVSDELRLKYRYLDLRRPEMNNIFKMRHTVTRTFRNKLDALGFFDIETPYLTKSTPEGARDYLVPSRVYPGNFYALPQSPQILKQLLMTAGFDKYYQIVRCFRDEDLRGDRQPEFTQIDLETSFLTKEKIQAITEDMLIDVVKEAKGITIEKPFPRMTYKEAMDRFGSDKPDIRFGLELQNVSEVVKDVDFKVFQSAIENGGEVKAINAKAAAANFSRKDLDALGIFVSNYGAKGLAWLKVEAGELKGPIAKFFPEEKALELKAALKAEDGDLLLFAADKADIVAASLGALRNKLGKDLNLINEDELAFLWVTDWPLFEYDEEAGRYVSAHHPFTLPKEEDIPLLETDSSKVMAEAYDIVLNGYEIGGGSLRIYKKEVQESMFRALGFTDESAKEQFGFLMDALEYGTPPHGGIALGLDRIVMILAGRNNLRDTIAFPKTGSAVDPLTNAPGEVSDAQLDELKLQITKKELN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HETR_NOSP7
Sequence: MSNDIDLIKRLDPSAMDQIMLYLAFSAMRTSGHRHGAFLDAAATAAKCAIYMTYLEQGQNLRMTGHLHHLEPKRVKIIVEEVRQALTEGKLLKMLGSQEPRYLIQLPYVWLEKYPWQPGRSRVPGTSLTSEEKRQIEQKLPSNLPDAQLVSSFEFLDLIEFLHRRSQEDLPTEHQMPLSEALGEHIKRRLLYSGTVTRIDSPWGMPFYALTRPFYAPADDQERTYIMVEDTARYFRMMKNWAERRRNAMRLLEELDILPEKMEQAMEELDEIIRAWADKYHQDGGIAVVLQTVFGEKED
What is the function of this protein?
Controls heterocyst differentiation.  Dimerization is required for DNA-binding.  Has both a protease and a DNA-binding activity (By similarity).  Increased expression leads to more heterocysts than usual (PubMed:11274126).
What are the official names of this protein?
DNA-binding transcriptional activator HetR, Heterocyst differentiation control protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S48 family.
Protein: Y855_HAEIN
Sequence: MNLERLNEIEKPLLHIVKHDVMPALGCTEPISLALASATAAKYLGKTPERIEAKVSPNLMKNGLGVAVPGTGMVGLPIAAAMKVLSNTILIELLIISVLLHQKVCSISTDRLSKL
What are the official names of this protein?
UPF0597 protein HI_0855.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: ACCD_YERPY
Sequence: MSWIERILNKSNITQTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMSARARLHMLLDAGSEVELGSELEPKDILKFRDSKKYKDRISAAQKDTGEKDALVAMKGTLQGMPIVAASFEFAFMGGSMASVVGARFVRAVEQALEDNCPLVCFSSSGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASLAMLGDINIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPVMRQTLASILSKLTHQPQPSVVESKADTVAQPENQADV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_MYCPA
Sequence: MTEFRSGFVCLVGRPNTGKSTLTNALVGTKVAITSMRPQTTRHTIRGIVHREDFQIILVDTPGLHRPRTLLGKRLNDLVRDTYAEVDVIGLCIPADEAIGPGDRWIVEQIRATAPKTTLVAIVTKIDKVPKDRVAAQLVAVSELVGDSAEIVPVSAVTGAQVDIVIDVLAAALPPGPAYYPDGELTDEPEEVLMAELIREAALEGVRDELPHSLAVVIDEVNPREDRDDLIDVHALLYVERDSQKGIIIGKGGARLREVGTAARAQIEKLLGTKVYLDLRVKVAKNWQSDPKQLGRLGF
What is the function of this protein?
Exhibits GTPase activity.  Binds RNA but is probably not involved in ribosome assembly in mycobacteria.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: VP3_ROTYO
Sequence: MKVLALRHSVAQVYADTQTYIHDDSKDEYENAFLISNLTTHNILYLNYSFKTLKILNKSGIAAIEVQSPDELFALIRCNFTYDYENNIVYLHDYSYYTNNEIRTDQYWITKTDIINYLLPGWKLTHVGYNGKNTRGHYNFSFICQNAATDDDIIIEYIYSNELDFQNFLLRKIKERMTTSLPIARLSNRVFRDKLFPSIVNIHKKVINVGPRNESMFTFLNFPTIKQFSNGAYIVKHTIKLKQEKWLGKRISQFDIGQYKNMLNVVTTIYYYYNLYYSKPVIYMLGSAPSYWIYDIKQYSDFTFETWDPLDTPYSTIHHKELFFDKDINKLKDNSVLYIDIRTDRGNMDWKEWRKIVEQQTVNNLNIAYKYLSTGKAKVCCVKLTAMDLELPITAKLLHHPTTEIRSEFYAILDVWDIITIKRFIPKGVFYAFINNVTTENVFIQPPFKLKMSPTDYIVALYALSNDFNSRQDIINLINKQKQSLITVRINNTFKDEPKVSFKNIYDWTFLPTDFELKDSVITSYDGCLGMFGLSISLSPKPTGNNHLFIINGTDKYYKLDQYANHTGISRRSHQIRFSESATSYSGYIFRDLSNNNFNLIGTNVENSVSGHVYNALIYYRYNYAFDLKRWIYLHSIGKVAVEGGRYYEHAPIELIYACRSAKEFAILQDDLTVLRYANEIERYINKVYSITYADDPNYFIGIKFNSIPYEYDVKVPHLTLGVLFISDNMVHNVITVLKKMKTELFKMEISTSYTYMLSDNTYVANVSGVLSTYFKLYNMFYRNHVTFGQSRMFIPHITLSFSNKQTVRIESTKLRINSIYLRKIKGETVFDMSE
What is the function of this protein?
Counteracts the host innate immune response thanks to its phosphodiesterase that degrades the 5'-triphosphorylated, 2'-5' linked adenylate oligomers produced by the host cell IFN-inducible 2',5'-oligoadenylate synthetase (OAS).  The host RNaseL is therefore not activated.
What are the official names of this protein?
Protein VP3.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP3 family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. There are about 11 to 12 copies per virion.
Protein: RIPL2_RAT
Sequence: MEEPPVREEEDGEEDEGALAKSPLQLTTEDVYDISYVVGRELMALGSDPRVTRLQFKIVRVMEMLEALVNEGSLAVEELRMERDNLKQEVEGLRRAGVSGSEVNLGPDKMVVDLTDPNRPRFTLQELRDVLQERNKLKSQLLLVQEELQCYRSGLLPPRETPGGRREKDAMVTMGNGEKEERTIMKKLFSFRSGKHT
What is the function of this protein?
Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (PubMed:19812310).  Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity).  May function via activation of RAC1 and PAK1 (PubMed:19812310).
What are the official names of this protein?
RILP-like protein 2, Rab-interacting lysosomal-like protein 2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.
Protein: MAZ_HUMAN
Sequence: MFPVFPCTLLAPPFPVLGLDSRGVGGLMNSFPPPQGHAQNPLQVGAELQSRFFASQGCAQSPFQAAPAPPPTPQAPAAEPLQVDLLPVLAAAQESAAAAAAAAAAAAAVAAAPPAPAAASTVDTAALKQPPAPPPPPPPVSAPAAEAAPPASAATIAAAAATAVVAPTSTVAVAPVASALEKKTKSKGPYICALCAKEFKNGYNLRRHEAIHTGAKAGRVPSGAMKMPTMVPLSLLSVPQLSGAGGGGGEAGAGGGAAAVAAGGVVTTTASGKRIRKNHACEMCGKAFRDVYHLNRHKLSHSDEKPYQCPVCQQRFKRKDRMSYHVRSHDGAVHKPYNCSHCGKSFSRPDHLNSHVRQVHSTERPFKCEKCEAAFATKDRLRAHTVRHEEKVPCHVCGKMLSSAYISDHMKVHSQGPHHVCELCNKGTGEVCPMAAAAAAAAAAAAAAVAAPPTAVGSLSGAEGVPVSSQPLPSQPW
What is the function of this protein?
Binds DNA and functions as a transcriptional activator.
What are the official names of this protein?
Myc-associated zinc finger protein, MAZI, Pur-1, Purine-binding transcription factor, Serum amyloid A-activating factor-1, SAF-1, Transcription factor Zif87, ZF87, Zinc finger protein 801.
What are the subcellular locations of this protein?
Nucleus. Note=In brains of Alzheimer disease patients, present in a plaque-like structures.
Protein: ACP_AQUAE
Sequence: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_VIBC1
Sequence: MSALRTRLDELIAQTDLEVSEKQREQLVGYVELLDKWNKAYNLTSVRDPLEMLVKHILDSIVVSTHLPGERFIDVGTGPGLPGIPLAIMNPEKTFFLLDSLGKRIRFIKQVVHTLGLKNVTAIQSRVEEFQPEEKFDGVLSRAFASMTDMVEWCHHLPKQDSGVFLALKGLHPKDEIDLLPEWCSVTEVISLAVPELEGDRHLVILSRKEN
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_CORDI
Sequence: MANIEKTEFHVPAPVSAAGNQKSSLGNADVDARLQSNEGEVETSLRPRSLDEFIGQPKVRDQLNLVLSGAKSRGVAPDHVLLSGPPGLGKTTMAMIIAYELGTSLRMTSGPALERAGDLAAMLSNLMEGDVLFIDEIHRMARPAEEMLYMAMEDFRIDVIVGKGPGATSIPLELAPFTLVGATTRSGMLTGPLRDRFGFTAQMEFYEVEDLTKVVVRAAAVLGVSIDHDAAVEIASRSRGTPRIANRLLRRVRDFAEVNADGHINLAAAQAALVVFDVDEMGLDRLDRAVLEALIKGHGGGPVGINTLALAVGEEPSTVEEVCEPYLVRAGMVTRTGRGRVATATAWRHLGLEPPEGIIGSL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: URTF_STAAN
Sequence: MLDKNQLAKYKQDHLCEYEKIMSNNEKEALEEKVASLDLDFIAKLYNDLYINKKTIDDVSAVSEVKYDIKSQMSDDEIKRLEEQGLQAIKEGQFAVLLMAGGQGTRLGYKGPKGSFEIEGVSLFELQANQLKTLNHQSGHTIQWYIMTSDINHEETLAYFEAHSYFGYDQEAIHFFKQDNIVALSEEGKLILNQQGRIMETPNGNGGVFKSLDKAGYLEEMSNNGVKYIFLNNIDNVLVKVLDPLFAGFTVEHDYDITSKTIQPKPGESVGRLVNVDCKDTVLEYSELDPEVANQFNNANIGIHAFKLGFILNAVNRELPYHLAIKNLKQLDENFGVIEQPTLKFELFYFDIFTYGTSFVTLQVPREEEFSPLKNKEGKDSVATATEDLRRMGLI
What are the official names of this protein?
Probable uridylyltransferase SA1974.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 1 family.
Protein: GUAC_LEPCP
Sequence: MEIFDYDNVLLLPRQCRVESRSECDPSVEFGPRRFKLPVVPANMKTVLDERIARWLAANDYFYVMHRFDLDALAFARSMREQGLCVSISSGVKPADYAVIDSLATSGVGADYITIDIAHGHAESVRRMIAHIKQRLPEAFVIAGNVGTPEALIDLENWGADATKVGIGPGKVCITRLKTGFGTGGWQLSALKWCARVATKPIIADGGIRHHGDIAKSVRFGAAMVMVGSLFAGHEESPGDTVEVDGRLYKEYYGSASDFNKGEYKHVEGKRILEPVKGRLADTLREMREDLQSSISYAGGRQLSDLRRVNYVILGGENAGEHLLM
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: SSRP_BIFLD
Sequence: MPKETGEKLIVQNKKARHDYAIEDKYEAGLALTGTEVKSLREGRASLSEAFISIDRRGEMWLEGANIPEYLNGTWNNHAPKRKRKLLLHRLQITKLARGIEAKGYTIVPLSLYFKDGRVKAEIALARGKKEFDKRQALREEQDKREALRAMRYANMRH
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: TATB_MYCTA
Sequence: MFANIGWWEMLVLVMVGLVVLGPERLPGAIRWAASALRQARDYLSGVTSQLREDIGPEFDDLRGHLGELQKLRGMTPRAALTKHLLDGDDSLFTGDFDRPTPKKPDAAGSAGPDATEQIGAGPIPFDSDAT
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.