PharMolix/UniProtQA huggingface dataset:
Protein: SEC11_COCP7
Sequence: MLAGLSPHLSNLRRSLTQVLNFALVLSTAFMMWKGLSIYTNSSSPIVVVLSGSMEPAFQRGDLLFLWNRSPRAEVGEIVVYNVRGKDIPIVHRVVRAFGDDEKSPKETNGQKKKKVMSSVKKDSIAAGALHSDSALVSHRILTKGDNNIADDTELYAQGQDYLDRKLDLVGSVRGYIPAVGYVTIMLSEHPWLKTVLLGIMGAMVILQRE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: CLCA_SALEP
Sequence: MKTDTSTFLAQQIVRLRRRDQIRRLMQRDKTPLAILLMAAVVGTLTGLVGVAFEKAVSWVQNMRIGALVQVADHAFLLWPLAFILSALLAMVGYFLVRKFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFIGGMGTLGAGMVLGREGPTVQIGGNLGRMVLDVFRMRSAEARHTLLATGAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAPIIEVGKLSDAPVNTLWLYLILGIIFGCVGPVFNSLVLRTQDMFQRFHGGEIKKWVLMGGAIGGLCGILGLIEPEAAGGGFNLIPIAAAGNFSVGLLLFIFITRVVTTLLCFSSGAPGGIFAPMLALGTLLGTAFGMAAAVLFPQYHLEAGTFAIAGMGALMAASVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILARTLAKQDAEQAAKNQNAPAGENT
What is the function of this protein?
Proton-coupled chloride transporter.  Functions as antiport system and exchanges two chloride ions for 1 proton.  Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
H(+)/Cl(-) exchange transporter ClcA.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAH_PECAS
Sequence: MKGKFSIALMLSACFSASASDSVHWGYEGSGDPAHWGKLSPDFSLCETGKNQSPVNIQQALNAQHDPLQLAFQSGTQQIINNGHTVQVNVSSGNTLLLDNETFALQQFHFHAPSENEIDGKQFPLEGHFVYKNADGALTVIALMFQEGAANPQLATAWQQIPAHVDQAEDVRTPIAIQALLPTSLNYYRFSGSLTTPPCSEGIRWLVLDHPVTASAEQINQFSSVMHHANNRPIQPLNGRIIIH
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase, Carbonate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RK2_TUPAK
Sequence: MGLRLYKPYTASTRNRSVSDFSEITEKKPEKTLTSWVFRSKGRNNRGIITSRHLGGGHKRLYRLIDFKRQKIGILGKVATIEYDPNRNARIVLLHYQDGAKGYILHPRGLKVGGTVVTSPEAPILIGNCLPLKAIPLGTEVHNVELYSGMGGQLSRAAGSSAQIVAKEGRFVTLRLPSGEVRLVSQNCWATIGQVGNVDANNIRIGKAGRMRWLGRRPKVRGVVMNPNDHPHGGGEGRSPIGRKCPVSLWGRLALGERTRKSKKYSNKLILKRRKASK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TYW4_ASHGO
Sequence: MSSMPVHIERPAELTAKQRLQLEKKVRSMKYADLAVQGTNTSSIASKRSVERLYADVLGTKVQGSNGQPREYFKYFVSKPLRRSPCINRGYWLRLMAIRTSLRCIAEGTGQRDILVVNLGCGYDPLPFQLLDHTDDAQSEFDDRMSFVDVDYPDLIAKKLEIVKNTPELQHILGGAAGDAAGPVVYRTAKYMAAACDLNDSAAFGALTESFHPRSDEVVVFIAEVSLAYMRPERADAIIEACGRIPNSHFILLEQLLPAGEHSPFSRTMLSHFKSNDSPLQSVSSYPTISEQEVRFKRLGFKNVNAGDMHQLWRSLDKELVSKVQAVEPFDELEEFYLFCHHYIIAHATNDLSFRFGPKYAFPQVPQSPSKSCSSNSPMELVTAVDTDLLQRKFGASVVVDSDTILFSFGCLHNKLENILVMGDHDGAFKISKGPAPPARMCHTFTKLDDRTIFLVGGRQSPTKPLGDAWLLKLRDGEWHWEMCAPLMYPRFRHNCVNVGKGKALIYGGETDGATFLIYDCESNTYYEPVYPRTFPRKVSAAMCYDFQSNRGYILGGALDNMEVDDTLCTFAFDARTNSIEILETSSHPLYQRYGAKSVVREAGHMLIVGGVSPHMLFNDTTSIIEVELTTNKVNCLQIPSSLWKNHAQLLVGFELQIMSDGTVLIFGGGAVCYGFGAAWNGILRLGRETIAAIPLRIL
What is the function of this protein?
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.  May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 4, tRNA-yW synthesizing protein 4, Leucine carboxyl methyltransferase 2, tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.
Protein: ACCA_HAEDU
Sequence: MSQEYLDFELPIAELEAKIESLRSVCAQDGKIDLEDEINRLQHKSQELTKKTFANLDAWQVSRMARHPNRPYTLDYIEHIFTEFDELAGDRAFADDKAIVGGIARLDGRPVMVIGHQKGRVTKEKVKRNFGMPAPEGYRKALRLMEMAERFKMPIITFIDTPGAYPGIGAEERGQAEAIARNLREMSQLSVPIICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSAEKASMAAEVMGLTAQRLKELNLIDGIVDEPLGGAHRDVLKIAHNLKQQILADLAELDSLTTEALLERRYERLMSYGYV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEE_CLOAB
Sequence: MNYKVVEKFVSINGEGLKSGQLSVFIRFAGCNLNCNYCDTKWANEKDVKYTLMTEKEILSYIKETGVKNVTLTGGEPLLQDGIVELLNLLSLDSTLRVEIETNGSVSLENFLNFKNAPSFTMDYKLPDSSMENFMKTSNFKFLNKKDVIKFVVSSLKDLKKAMDIITEFNLSKKTNIYISPVFGRISPETIVDFMKDNKLNDVTLQIQIHKIIWNPNKRGV
What is the function of this protein?
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
What are the official names of this protein?
7-carboxy-7-deazaguanine synthase, CDG synthase, Queuosine biosynthesis protein QueE.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
Protein: RBCR_EMIHU
Sequence: MSDLPFTLDQLKIIKTIHREGSFKTAAKKLYISQPAVSRQVQNLERQLNTPIFYRDKRKARLTETGHILVKYAEQILSLCEETCQALDELKSINSGTLVIGASQTTGTYLMPRLIGIFRHKYPQISIELKVHSTRRISWGVANGEIDLAIVGGEVPPELQGTLEIISYAEDELALIIPQAHPFATLQSIQKEDLYRLRFIALDTQSTIRSVIENTLTQSGIDSRYFKIEMELNSIEAIKNAVQSGLGAAFVSVSAISKELELGILHWAKIEDVTIKRTLSILINPKRYYANPIKNFEKEIMEILLTSAASTNNP
What is the function of this protein?
Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression.
What are the official names of this protein?
Probable RuBisCO transcriptional regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RIBN_RHIL3
Sequence: MKDMNQTSLAVEPSRAVVGALWMVLAGIAFSLLNVVTQWLTMKLAFPSASAAFWQYGFAFLFSLPFLKRLGLAAMRTHYPWRHLTRVVLAALGVEAWVAGLAAVPIWQAIALVMTSPFFIILGARLFLGERVGPARWAATAAGFTGAMIILQPWSDGIGWAALLPVLSALLWGASSLITKSLTGIERPETITVWLLVLLTPINGGLALAAGFAVPTGATLALFLLAGLLTAVAQYFLTLAYAAADAAYVQPFDDLKLPLNVLAGWLFFGYAPAGYLWLGAALILSASLFIMRNEMRRERKPA
What is the function of this protein?
Transports riboflavin into the cell.  Can also transport FMN and FAD.  Required for normal nodule development during colonization of pea plant roots.
What are the official names of this protein?
Riboflavin transporter.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYA_BRUO2
Sequence: MAGVNEIRSTFLDYFRKNGHEVVPSSPLVPRNDPTLMFTNAGMVQFKNVFTGLEHRSYNRATTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEDAISFAWNLITREFGLPKDKLLVTVYHTDDDAANFWKKIAGLSDDRIIRIPTSDNFWAMGDTGPCGPCSEIFYDHGDHIWGGPPGSPEEDGDRFIEIWNLVFMQFEQQTPELRIDLPRPSIDTGMGLERIAAVLQGVHDNYDIDLFKALIRASEEATGVKAEGDFRASHRVIADHLRASSFLIADGVLPSNEGRGYVLRRIMRRAMRHAQLLGAKEPLMWRLLPALIREMGQAYPELIRAESLISETLKLEETRFRKTLERGLGLLSDASENLAEGDRLDGETAFKLYDTYGFPLDLTQDALRQRGIAVDTEGFNVAMERQKAEARANWTGSGEAATETIWFGIKDKVGATEFLGYETESAEGVIASLVRDGVEVPSVREGETISVVVNQTPFYGESGGQQGDTGTISGEGFVIAVKDTQKKGEGVFVHIGEVTEGTAKAGDVVELKVDSARRTRIRSNHSATHLLHEALRETLGTHVAQKGSLVAPDRLRFDFSHPKPISAEELEAVENLANEIILQNAPVTTRLMAVDDAIAEGAMALFGEKYGDEVRVVSMGTAKHGSKAGKAYSVELCGGTHVRQTGDIGLVRIISEGGVAAGVRRLEALTGEAARLYLEEQDERVKAIASALKTTSADVLDHVNALIDERKKLERELADARKKLALGGGSSDGDSAVEAVNGVNFLGKIVTGVSPRDLKPLADEGKKQVGSGVVLFIGVGEDGKASAVAAVTEDMVGRFSAVDLVRAASAALGGAGGGGRPDMAQAGGPDGAKAADAIAAVKALIA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIP2_STAAR
Sequence: MLRGQEERKYSIRKYSIGVVSVLAATMFVVTSHEAQASEKIPTTNAAAQKETLNQPGEQGNAITSHQMQSGKQLDDMHKENGKSGTVTEGKDMLQSSKHQSTQNSKIIRTQNDNQVKQDSERQGSKQSHQNNATNKTERQNDQIQNTHHAERNGSQSTTSQSNDVDKSQPSIPAQKVIPNHDKAAPTSTTPPSNDKTAPKSTKEQDATTDKHPNQQDTHQPAHQIIDAKQDDNVHQSNQKPQVGDLSKHIDGQNSPEKPTDKNTDNKQLIKDALQAPKTRSTTNAAADAKKVRPLKANQVQPLNKYPVVFVHGFLGLVGDNAPALYPNYWGGNKYKVIEELRKQGYNVHQASVSAFGSNYDRAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYKGIMPNWEPGKKVHLVGHSMGGQTIRLMEEFLRNGNKEEIAYHKAHGGEISPLFTGGHNNMVASITTLATPHNGSQAADKFGNTEAVRKIMFALNRFMGNKYSNIDLGLTQWGFKQLPNESYIDYIKRVSKSKIWTSDDNAAYDLTLNGSAKLNNMTSMNPNITYTTYTGVSSHTGPLGYENPDLGTFFLMDTTSRIIGHDAREEWRKNDGVVPVISSLHPSNQPFVNVTNDEPATRRGIWQVKPIIQGWDHVDFIGVDFLDFKRKGAELANFYTGIINDLLRVEATESKGTQLKAS
What are the official names of this protein?
Lipase 2, Glycerol ester hydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: DRRA_LEGPH
Sequence: MSIMGRIKMSVNEEQFGSLYSDERDKPLLSPTAQKKFEEYQNKLANLSKIIRENEGNEVSPWQEWENGLRQIYKEMIYDAFDALGVEMPKDMEVHFAGSLAKAQATEYSDLDAFVIVKNDEDIKKVKPVFDALNNLCQRIFTASNQIYPDPIGINPSRLIGTPDDLFGMLKDGMVADVEATAMSILTSKPVLPRYELGEELRDKIKQEPSFSNMVSAKKFYNKAIKDFTAPKEGAEVVSVKTHIMRPIDFMLMGLREEFNLYSEDGAHLSAPGTIRLLREKNLLPEEQIARIESVYNQAMSKRFELHAEHKKEHDEMPYSDAKAMLDEVAKIRELGVQRVTRIENLENAKKLWDNANSMLEKGNISGYLKAANELHKFMKEKNLKEDDLRPELSDKTISPKGYAILQSLWGAASDYSRAAATLTESTVEPGLVSAVNKMSAFFMDCKLSPNERATPDPDFKVGKSKILVGIMQFIKDVADPTSKIWMHNTKALMNHKIAAIQKLERSNNVNDETLESVLSSKGENLSEYLSYKYATKDEGREHRYTASTENFKNVKEKYQQMRGDALKTEILADFKDKLAEATDEQSLKQIVAELKSKDEYRILAKGQGLTTQLLGLKTSSVSSFEKMVEETRESIKSQERQTIKIK
What is the function of this protein?
Virulence effector that plays a key role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs).  Acts as a GDP-GTP exchange factor (GEF) for the small GTPase Rab1 (RAB1A, RAB1B or RAB1C), thereby converting Rab1 to an active GTP-bound state, leading to the incorporation of Rab1 into LCVs.  Also shows RabGDI displacement factor (GDF) activity; however, this probably represents a passive activity following the GEF activity.  Also acts as an adenylyltransferase by mediating the addition of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby rendering RAB1B constitutively active.  Also has adenylyltransferase activity towards Rab6 and Rab35.  Also displays guanylyltransferase activity by mediating the addition of guanosine 5'-monophosphate (GMP) to host RAB1B in vitro; however such activity remains uncertain in vivo.  Specifically binds phosphatidylinositol 4-phosphate (PtdIns(4)P) lipids on the cytosolic surface of the phagosomal membrane shortly after infection.
What are the official names of this protein?
Multifunctional virulence effector protein DrrA, Defects in Rab1 recruitment protein A.
What is the protein family that this protein belongs to?
Belongs to the DrrA family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Translocated into the host cell via the type IV secretion system (T4SS). Membrane association is mediated by PtdIns(4)P-binding.
Protein: Y2485_RHOPT
Sequence: MTDALTRIYVDADACPVKDEVYKVAERHHLPVTLVAGGFIRVPQHPLIERVAAGSGMDAADDWIAERIKPGDIVITADIPLASRCVKAGATAIAPNGKPFTEESIGMTLAVRNLMTDLRSTGEITGGPRAFSPRDRSTFLSALDSAIRRIARRRAAPT
What are the official names of this protein?
UPF0178 protein Rpal_2485.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: TPIC_FRAAN
Sequence: MAVASTSLASQLSGPKSLSQPYSGLRRSCPKLDQSHSSLFQHLSLSSSSRKASRAVVAMAGTGKFFVGGNWKCNGTKDLISKLVSDLNSAKLEPDVDVVVAPPFLYLDQVKSSLTDRIEISGQNSWVAKGGAFTGEISVEQLKDIGRKWVILGHSERRHVIGEDDQFIGKKAAYALNEGLGVIACIGEKLEEREAGKTFDVCYEQLKAFADAVPSWENIVVAYEPVWAIGTGKVASPQQAQEVHVAVREWLKKNVSAEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKGPEFATIVNAVTSKKVAA
What are the official names of this protein?
Triosephosphate isomerase, chloroplastic, TIM, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RLP21_ARATH
Sequence: MLLAMEGKLFLCQYLIWVMLLLGQLHGCTSCIEKEREALLELKKYLMSRSRESGLDYVLPTWTNDTKSDCCQWDGIKCNRTSGRVIELSVGDMYFKESSPLNLSLLHPFEEVRSLNLSTEGYNEFNGFFDDVEGYRSLSGLRNLKIMDLSTNYFNYSTFPFLNAATSLTTLILTYNEMDGPFPIKGLKDLTNLELLDLRANKLNGSMQELIHLKKLKALDLSSNKFSSSMELQELQNLINLEVLGLAQNHVDGPIPIEVFCKLKNLRDLDLKGNHFVGQIPLCLGSLKKLRVLDLSSNQLSGDLPSSFSSLESLEYLSLSDNNFDGSFSLNPLTNLTNLKLFKLSSRSHTIQVKMESTWQPNFQLSVVVLRFCSLEKIPSFLLYQKKLRLVDLSSNNLSGNIPTWLLTNNPELEVLQLQNNSFTIFPIPTMVHNLQIFDFSANNIGKFPDKMDHALPNLVRLNGSNNGFQGYFPTSIGEMKNISFLDLSYNNFSGKLPRSFVTGCVSIMFLKLSHNKFSGRFLPRETNFPSLDVLRMDNNLFTGNIGGGLSNSTMLRILDMSNNGLSGAIPRWLFEFPYLDYVLISNNFLEGTIPPSLLGMPFLSFLDLSGNQFSGALPSHVDSELGIYMFLHNNNFTGPIPDTLLKSVQILDLRNNKLSGSIPQFDDTQSINILLLKGNNLTGSIPRELCDLSNVRLLDLSDNKLNGVIPSCLSNLSFGRLQEDAMALNIPPSFLQTSLEMELYKSTFLVDKIEVDRSTYQETEIKFAAKQRYDSYSGRSEFSEGILRLMYGMDLSNNELSGVIPTELGDLLKLRTLNLSHNSLLGSIPSSFSKLIDVESLDLSHNMLQGSIPQLLSSLTSLAVFDVSSNNLSGIIPQGRQFNTFEEESYLGNPLLCGPPTSRSCETNKSPEEADNGQEEEDDKAAIDMMVFYFSTASIYVTALIGVLVLMCFDCPWRRAWLRIVDAFIASAKHVLP
What are the official names of this protein?
Receptor like protein 21, AtRLP21.
What is the protein family that this protein belongs to?
Belongs to the RLP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: MNMA_CHLAB
Sequence: MNKTVVVAMSGGVDSSVVAYLLKKYTSYRVLGIFMKNWEEEDSNGLCSTAKDYEDVERVAEQLDIPYYTVSFAREYRERVFSRFLKEYSQGYTPNPDVLCNREIKFDLLQKKVVELGGDFLATGHYCRLDVKSQRVGLLRGKDPHKDQSYFLCGTHPESLKNVLFPLGDMTKREVRSIAAQAGLATAQKRDSTGICFIGKRPFKSFLEQFVPNVEGEIIDYDSQKIVGNHEGAHYYTIGQRRGLDIGGSEKPCYVVGKDMEKNIVYIVRGEDHPLLYQQELTAKELNWFVSPESITRCSAKVRYRSPDEECEILHTGTQDTVRVRFTSPVKAITPGQTIAFYDGERCLGGGIIEVAMTPHSV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD9_HUMAN
Sequence: MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV
What is the function of this protein?
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:8478605, PubMed:14575715, PubMed:18541721).  Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity).  In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity).  In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480).  Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity).  Acts as a receptor for PSG17 (By similarity).  Involved in platelet activation and aggregation (PubMed:18541721).  Regulates paranodal junction formation (By similarity).  Involved in cell adhesion, cell motility and tumor metastasis (PubMed:8478605, PubMed:7511626).
What are the official names of this protein?
CD9 antigen, 5H9 antigen, Cell growth-inhibiting gene 2 protein, Leukocyte antigen MIC3, Motility-related protein, MRP-1, Tetraspanin-29, Tspan-29, p24.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
Protein: GRCA_SHIBS
Sequence: MITGIQITKAANDDLLNSFWLLDSEKGEARCIVAKAGYAEDEVVAVSKLGDIEYREVPVEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: SSTT_MARN8
Sequence: MSSRRLGVVRPLLQMGLIPQITIGIIAGVLLAVIWPDTAQSVSLLGQLFISALKAVAPILVFALVTAAIANHQQGQPTHIRGVLLLYVIGTLVAAVVAVIASFVFPTELTLELPEVSGNPPGGVVEILRNLLLSAVTNPVSALMEGNFIAILAWAVGLGLMLRQGRDATRQVVNDLSDAISGIVRAVIRFAPLGIFGLVANTLADAGIGALLEYGRLLAVIVGCMLFVALVTNPLIVFLHTRQNPYPLVFACLRGSAITAFFTRSSAANIPVNLNLCDRLGLDPDTYAISIPLGATINMAGAAITISVITLAAANTLGIPVDFPTALLLCVVSSIAACGVSGVAGGSLLLIPLATSLFGISTEVAMQVVAIGFVISVVQDSTETALNSSTDVLFTAAACRSAEVRESA
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUVA_LACPL
Sequence: MYEYFLGQVTDVTPGYVVIEVSGIGYKVLTANPYRYQVGPTAVKMYIHQAVSENGMSLFGFFDADEKALFEKLLGVSGIGPKSALAILANNDHAGLIQAINQENATYLTSFPGVGKKTAQQIVLDLKGKLNDLNVDVTGQTALDVDAPAVDGALADALAALEALGYSKADVKKVTKKLETFSQTQGADTNTLLSEGLRLLMKK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: LSPA_RICCK
Sequence: MLLLLKKIYLTFARSSRIIITLVIIDQLSKWWFIDNLRWKPGLMLKVTAFLNMVYTWNYGISFGLMREYYQYSNAVFILTNSIIVCYLYYLMVCSKTIRGFAGYSFVIGGAVGNLIDRLFRGAVFDFIHFYYKNYSFPVFNLADCFITIGVIILIEDYYSTKKIIEEKAKEHYDNAQIKAMAEKIRNTDHNGDNKI
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COXX1_NITWN
Sequence: MSVVDQKAVELPPRISEAGVADYFALLKPRVMSLVIFTALVGLMIAPGHIHPVLGFIAILCIAVGAGASGALNMALEGDIDVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGALVNWYAGGLLAFTIFFYVVIYTMGLKRRTAQNIVIGGAAGALPPVVAWAAATGSLSVEPLLLFLIIFFWTPPHFWALALFRSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPWPLGYFDWVYGVTSLILGAGMLVLAIEVYRHRTGSQALRATRRLFAFSILYLFALFAVLLLDVVAKAVAPLIW
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase 1, Heme B farnesyltransferase 1, Heme O synthase 1.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAK_JANMA
Sequence: MGKIIGIDLGTTNSCVAIMEGGKPKVIENSEGARTTPSVIAYQEDGEILVGAPAKRQAVTNPKNTLYAVKRLIGRKFDEKEVQKDIGMMPYQIVKADNGDAWISVRDKKLAAQQISAEILRKMKKTAEDYLGEEVTEAVITVPAYFNDAQRQATKDAGRIAGLDVKRIINEPTAAALAFGLDKGGKGDRKIAVYDLGGGTFDISIIEIADVDGEMQFEVLSTNGDTFLGGEDFDQRIIDYIIDEFKKINGLDLSKDAIALQRIKASAERAKIELSSSQQTEINEPYIAMANGAPVHLNLKITRAKLESLVEELISKTIEPCRTAIKDAGVKVSDIDDIILVGGMTRMPKVQETVKDFFGKDPRKDVNPDEAVAVGAAIQGSVLSGDRKDLLLLDVTPLSLGIETLGGVMTKMIQKNTTIPTKFSQVFSTADDNQPAVTIKVFQGEREMAVGNKALGEFNLEGIPPSARGTPQIEVTFDIDANGILHVGAKDKATGKENKITIKANSGLTEEEIQKMVQDAEANAEEDKRLKELAEAHNQGDALVHSTRKALTEYGDKLEAGEKEKIEAAIAELEEALKGSDKAAIDEKSAAVTTAAQKLGEKMYADMQAQQAAGAAGGDAGAGDAGHSHADSKPQQDDVVDADFKEVKDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: IMA1A_DICDI
Sequence: MSSRDKQDSRKKEFKKSLDSETARRKREENSIGIRKNAREELMLKRRGIVQPNPSTSYQIIVPPEVQEQFQKYENETMENKIKNLPGLVTALNSNDQAYVYSSLVQFRKLLSIHAYPPIDQVIECGIIPKLNQLLQCNNPKVQFESAWALTNIASGNNRQTQTVMESGSVPIFIQLLCAETTDEVKEQCAWALGNIAGDTVDSRNYLLKYGAMNALIPLLHYGEDNGATTTSANSERKIGLIQNVVWTISNLCRGKPQPDFSVVSQCLPAINELIRIENLPSEIYGDLCWALSYLCDGPNTKIQAVIDSGVVPRLVKLLEYPDSIVFTPALRAVGNIVTGESSQTQIVIDNNGVELITRLLAVQKKSIRKESCWALSNITAGEPSQIDVVVSNPKTVTTLISLLSHSEHDIKREACWALSNSTNNSSTKSIQTLVRHNILKHFIDLLNSQDLVILKIVLEGLINIIKEGEKTKTKTGVNPYVNLISEMQGESIIYDLQEHQSKDVYKKAFELIEFFESSDYSDSENSEPNINQNGQYEFSSNYNSNSINI
What is the function of this protein?
Functions in nuclear protein import via a substrate-importin alpha-beta transport complex that passes though the nuclear pore complexes (NPC).  Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (By similarity).
What are the official names of this protein?
Probable importin subunit alpha-A, Karyopherin subunit alpha-A.
What is the protein family that this protein belongs to?
Belongs to the importin alpha family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope.