PharMolix/UniProtQA huggingface dataset:
Protein: SDE2_MOUSE
Sequence: MAEAAVVAWVRGPGTVWKALPCASVGCSVRDVIYRHCQEQEVPVECFFVTCNGVLVNAGDKVQHGAVYSLEPRLRGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWVKQQAEREAEKEQRRLERLQRKLAEPAHCFTSPDYQRQCHEMAERLEDSVLKGMQAASSKMVSAEITETRKRPNKSKTDQETSAKKRKRKCFWLGMDGLEAAEGSSTGSSEDSSEDDSEDAPGTSEQSCCAREDGIDAVEVAADRPGSPRSSASGTHSESPEKLQCPVTEPGQGILENTGTEPGETSDKECNERKTVTDPEETPARKETESHEATEKDQKTGMSGGDRAAMVLSGEDRKSVPAANLEGNNSGDTALGLEAVDLSAFSSAAELESLGLERLKCELMVLGLKCGGTLQERAARLFSVRGLTKELIDPALFAKPSKGKKK
What is the function of this protein?
Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity).  Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity).
What are the official names of this protein?
Splicing regulator SDE2, Replication stress response regulator SDE2.
What is the protein family that this protein belongs to?
Belongs to the SDE2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLHC1_MACFA
Sequence: MSVHQIRKRAVLPPIICRSDKEFLESMQRYIITETERLGYNEEGPADEYYIIYRNVFDKVIEHVTAYKSILTSIKKEYDAFIETIKKGRRTAFCLHGKLKGLAAEPTALVYHRKRTIQLEAKMRIIENNSSKIQSQIDQIKQSRAAYDTKEVKYCTFSKDPSKPIPGMTLQESMNLDALTKYMKHLEDKYAEIKQAMLIKYVPAQRKSDLDEEMIVLLKRRDVAENLNRKLQFCHQRLQIISQALTSWVKSDMSSPFQDFVEQIQKTKYLQGDQGIVEELMEDDPHRAKEAEIMLHYIERFNELISLGEYEKAACYAANSPRRILRNIGTMNTFKAVGKIRGKPLPLLLFFEALFITSHAFRCPVDAALTLEGIKCGLSEKRLDLVINWVTQQRLTFSEEAGDVICDYGEQDTYNKAKCLALAQIIYSECGLHKKAILCLCKQGQTHRVMEYIQQFKDFTTDDLLQLLMSCPQIELIQCLTKELNEKQTSLSFGLAILHLFSIDKKKIGIKLLQEINKGGIDAVESLMINDSFCSTERWQEVANICSQNGFDKLSNDIMSILRSQAAVTEISEEDDAVNLMEHVFW
What are the official names of this protein?
Clathrin heavy chain linker domain-containing protein 1.
Protein: MLTF_SULDN
Sequence: MKRGSVALFAISFFAFGWMTHALYNDAYKMIKESTLKKIKKSGALNVVLLNAPSTYYIGSDGPKGFEYDLLESYANHLGVKLNITTANTIKEALELSKNPDIHITSASLTKTPEREKEFNFGPSYFEAQEQVVCNKSLLLDGRFPSDADSLSGLRVVVGDSTSYSETIESLKKEGFDINATYTAEYSTEELISQVDTHEIDCTIIDSNIYALNQRYFKNIVLAFDISNRRQQAWILTPDSKMLKNDMYSWLNTVNQSGEMARLKDHYYSYVLFFDYYDTVMFYKRIKTRLPKYESYFKEAAVKYEIPYSALAALSYQESHWNPNAVSYTGVRGLMMLTQDTASMLGVKNRIDPQESIFGGAKHLDQMIKSVHADVTGEDRLKFALAAYNVGLGHVADAQKLAQQLGLNQNSWADLKKVLPMLSQKKYYRTLKHGYARGNEAVKYVDAIYDYRDILQKNDVEVSLTTK
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: ARGC_ALIF1
Sequence: MLKTAIIGASGYTGAELALMVFKHPHLSLSGLYVSENSLDKGKAISELHGSLKGIVDEALQPLVNVNQAAKECDVILLATAHEVSHNLAATFLENGCVVFDLSGAFRVKKEGFYSEFYGFEHQYEAWLDKAVYGLAEWNAEAIAKAQLVAVPGCYPTASQLALKPLVKSELLDKNQWPVINATSGVTGAGRKASLTSSFCEVSLQPYGVFNHRHQPEIAAHLGCDVIFTPHLGNFKRGILATITTKLAKGVTEKEIQEAFETAYTQTPAVRLLENEMPKIQSVEKTPFCDIGWKVQGEHLIVVSAIDNLLKGASSQAMQCINIRFGFPVLTALI
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSBZ4_ORYSJ
Sequence: MDIEAFIHGGSGGGDADADHPLGIFSAADLSGFGFADSSTITGGIPNHIWPQSQNLNARHPAVSTTIESQSSICAAASPTSATNLNMKESQTLGGTSGSDSESESLLDIEGGPCEQSTNPLDVKRVRRMVSNRESARRSRKRKQAHLADLESQVDQLRGENASLFKQLTDANQQFTTSVTDNRILKSDVEALRVKVKMAEDMVARGALSCGLGHLGGLSPALNPRQACRVPDVLAGLDYAGDDPFTAGLSQPEQLQMPGGEVVDAWGWDNHPNGGMSK
What is the function of this protein?
Probable transcription factor that binds to the DNA specific sequence 5'-TGAGTCA-3' found in seed storage protein gene promoters.
What are the official names of this protein?
bZIP transcription factor RISBZ4, Rice seed bZIP4, bZIP transcription factor 15, OsbZIP15.
What are the subcellular locations of this protein?
Nucleus.
Protein: PUR8_PSEAE
Sequence: MQLSSLTAVSPVDGRYAGKTSSLRPIFSEYGLIRFRVMVEVRWLQRLAAHAGIPEVAPFSAEANALLDSLASDFQLEHAERIKEIERTTNHDVKAVEYLLKEQAAKLPELAAVSEFIHFACTSEDINNLSHALMLREGRDSVLLPLMRQIAEAIRELAVKLADVPMLSRTHGQPASPTTLGKELANVVYRLERQIKQVAGIELLGKINGAVGNYNAHLSAYPEVDWEANARQFIEGDLGLTFNPYTTQIEPHDYIAELFDAIARFNTILIDFDRDVWGYISLGYFKQKTVAGEIGSSTMPHKVNPIDFENSEGNLGIANALFQHLASKLPISRWQRDLTDSTVLRNLGVGIAHSIIAYEASLKGIGKLELNAQRIAEDLDACWEVLAEPVQTVMRRYGVENPYEKLKELTRGKGISAEALQTFIEELAIPAEAKVELKKLTPAGYVGNAAAQAKRI
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: TPCE_RANDY
Sequence: MFTLKKSMLLLLFLGTISLTLCEEERDANEEEENGGEVKVEEKRFIGPIISALASLFGG
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Temporin-CDYe.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KDSB_RALPJ
Sequence: MSHAPFIAVIPARLASTRLPNKPLADIDGKPMVVRVAERAHQSSAARVVVATDAASVADACMQHHVEAVLTRADHASGTDRLAEVATVLGLPDDAIVVNVQGDEPLIAPTLIDNVAAHLRDHPDCAIATAAHPIHDPADVFNPNVVKVVLDAADRALLFSRAPLPWARDTWTPAVMAGSVAERPLPAMPVLRHIGIYAYRAGFLRRFPQLAAAPIEQTEQLEQLRAMWHGERIAVLTTDDAPAAGVDTPEDLTRVRAAWAELLAQDGP
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSPPA_TRIST
Sequence: MELIRVLANLLILQLSYAQKSSELVFGGDECNINEHRSLVVLFNSNGFLCGGTLINQDWVVTAAHCDSNNFQLLFGVHSKKILNEDEQTRDPKEKFFCPNRKKDDEVDKDIMLIKLDSSVSNSEHIAPLSLPSSPPSVGSVCRIMGWGKTIPTKEIYPDVPHCANINILDHAVCRTAYSWRQVANTTLCAGILQGGRDTCHFDSGGPLICNGIFQGIVSWGGHPCGQPGEPGVYTKVFDYLDWIKSIIAGNKDATCPP
What is the function of this protein?
Snake venom serine protease that activates plasminogen.
What are the official names of this protein?
Venom plasminogen activator TSV-PA, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYS_NAUPA
Sequence: MIDLKLLEKDFENVSKRLKLKGVDENNLEEIKKLFKEKKEIKTTLDKLLEQRNILSKQIGNFMKNGEKDKAEEIKKEVNSLKEEISVLEEKLKTIEDSLLQKALVIPNIPDEDVPIGKDEDENVEIKRVGEIPTFDFEPKPHDELGEKLDWLDFTRGVKLAKSRFTVMKKDAARLERALINFFLDHNREWGFEEVYVPFMVNRETMTGTGQLPKFEEDLFKIENEELYLIPTAEVPLTNLFRDEIITNLDEPIKLTAYTPCFRKEAGSYGKDTKGIIRQHQFDKVELVAITKPEDSDKMFDEMVACASNALEKLGLPYRQLMLCTGDLGFSAAKTIDLEVWIPSQNKYREISSVSNTRDFQARRAKIRYKDGKKNKLVHTLNGSSLAVGRTLVAIMENYQTKDGNIQIPEALKKYL
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PWP3B_MOUSE
Sequence: MDGKYVLCNWKDQLWPAKVLDRSESPSESKRKNTSSLEVEILSLDEKITVESTDTKVLSKSAVEAIMSSLAVQSEVIIAPREETAYERSLKMALEMVKEGTNLSQESMSEEQPTATASENVPEQPPDSPPHKKFRKLESNTQEDSASILLCSESDDSMTDDKLQVHTTGESMPSEMDTKATENLGCCQTDPSLADEDDKKEEKKKIDISAIMSVNLSLKEESEYIKEEKFVPSSEDLTVPKEESQDILPEAPLAVSSECSIVSENNMEDPGEGPSNQNLVSYANQNQSSVESDVGAETSTAGCSGDFQVSLPTRDTVSSDLLLQRLDLEDLEEEARASGKLLSLNPASAAALENDNEDDDEDLPRFILHYETRAFETGMIVWFKYQKYPFWPAVIKSIRRKERKASVLLVEADMSPQKKGVRVSLRRLKKYDCKEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADISYPVRKIIKQDTFRNIFPKLYNENVGEQLPMASQAKRVSFQKILPDRMKPARDRANKNLVDFIVNAKGTEDHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEIYKQIDQKMLTLIKDDKIKFVLEVLLPEAIICSISAVDGLDYEAAEAKYLKGPSLGCRERELYDSKILFEKRRRSLPNEGH
What are the official names of this protein?
PWWP domain-containing DNA repair factor 3B, PWWP3B, Mutated melanoma-associated antigen 1-like protein 1, MUM1-like protein 1, PWWP domain-containing protein MUM1L1.
What is the protein family that this protein belongs to?
Belongs to the PWWP3A family.
Protein: TRMN6_SHEPC
Sequence: MAFTFKQFHIDDLNCGMAVSTDAVVLGAWAPLTNAKQILDIGAGSGILGLMAAQRSQANITCIELDNTAAIACQHNIAQSPWASRIRLVQGSIQQLSQAEEYQGYFDHIICNPPYFEHGPQAQLSQRAMARHTDQLSFNELLAAIEQCLSPNGLASLILPIQSLHNFNHLLSQSRLEWVERVDIKSVEGKRANRVLCLLTTQTHRTVEPKVSELTLRDTSGQYSQAMVHLTQDFYLKL
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SA4A_NAJSP
Sequence: MKTLLLTLVVVTIVCLDLGYTLKCNKLVPLFYKTCPAGKNLCYKMFMVAMPKVPVKRGCIDVCPKSSLLVKYVCCNTDRCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes.  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
What are the official names of this protein?
Cytotoxin 4a, Cardiotoxin-4a, CTX-4a, Ctx4a.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: GALR2_HUMAN
Sequence: MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
What is the function of this protein?
Receptor for the hormone galanin and GALP.  Receptor for the hormone spexin-1 (PubMed:24517231).  The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
What are the official names of this protein?
Galanin receptor type 2, GAL2-R, GALR-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACP_NEIMF
Sequence: MSNIEQQVKKIVAEQLGVNEADVKNESSFQDDLGADSLDTVELVMALEEAFGCEIPDEDAEKITTVQLAIDYINAHNG
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_CAMFF
Sequence: MNLINNANKKLFEKINNLKNYSCQVKFSDAIEIEINDFDDNIIDLAKDLKPWRKGPFKLNATLIDSEWQSFIKFNGLKPFLNLKDKIVADVGCNNGYYMFKMLELEPKSIVGFDPSVLSFLQFSFINHFVKSNIKFELLGVQDLPNYNIKFDTILCLGVLYHRSDPIKTLKELKSSLNKGGEVFIDTMFIQRDDEFVLSPKSTYSKIPNIYFIPSIKALRNWCERAKFKTFDILSIKNTDFNEQRKTQWIYGESLENFLDPNDPKLTIEGYPAPKRVYVRLS
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: RS11_NEIG1
Sequence: MAKANTASRVRKKVRKTVSEGIVHVHASFNNTIITITDRQGNALSWATSGGAGFKGSRKSTPFAAQVAAEAAGKVAQEYGVKNLEVRIKGPGPGRESSVRALNALGFKITSITDVTPLPHNGCRPPKKRRI
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ENO_BURP6
Sequence: MSAIVDIIGREILDSRGNPTVECDVLLESGTMGRAAVPSGASTGSREAIELRDGEAGRYGGKGVLKAVEHINTEISEAIMGLDASEQAFLDKTLLELDGTDNKSRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQLPVPMMNIVNGGAHANNSLDIQEFMIVPVSQPTFREALRCGAEVFHALKKILGDRGMSTAVGDEGGFAPNFGSNDECLSTILQAIEKAGYRAGEDVLLALDCAASEFYHDGKYQLAGEGLQLSSAEFTDYLATLADKFPIVSIEDGMHEGDWDGWKLLTERLGKKVQLVGDDLFVTNTRILKEGIEKGIANSILIKINQIGTLTETFAAIEMAKRARYTAVISHRSGETEDSTIADIAVGLNAGQIKTGSLSRSDRISKYNQLLRIEEDLGDIASYPGKSAFYNLR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RAB19_XENLA
Sequence: MPGRGSLEDDPFDFLFKIILIGDSNVGKTCVVHRFQSGIFMDNQQNTIGVDFTVRSLNINGKKVKVQVWDTAGQERFRTITQSYYRSAHGAIIAYDITRRQSFESVPHWIYEAGKYGAANLMLMLMGNKSDLAEKRQILFEEACTLAEKHGLLAVLETSAKESHNVDEVFLLMAKELIARNTFHYHNESPRNSFILDSKPVLAPPEPDKSCLC
What are the official names of this protein?
Ras-related protein Rab-19.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: SYGA_CHESB
Sequence: MNASALPHMHPSRSFQGLILTLHSYWAAQGCVILQPYDMEVGAGTFHPATTLRSLGPRPWNAAYVQPSRRPKDGRYGENPNRLQHYYQYQVILKPNPPNLQELYLGSLAAIGLDPLLHDIRFVEDDWESPTLGAWGLGWECWCDGMEVSQFTYFQQVCGIECAPVSGELTYGLERLAMYVQGVDNVYDLNFNGLEGSDKVTYGEVFLQAEQEYSRHNFEYANTEMLFRHFEDAERECRALLEAGAPRPSDNAALHRMVFPAYDQCIKASHVFNLLDARGVISVTERQSYILRVRDLAKACGEAFLNTEAGGATLATAA
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_SYNS3
Sequence: MDYKTAGVDVEAGRAFVNRIRKSVEATHRPEVVGGLGGFGGLMRLPAGLKKPLLVSGTDGVGTKLELAQDHGGHHNVGIDLVAMCVNDVITSGAEPLFFLDYMATGALSPEAMATVVEGIAEGCRGSGCALLGGETAEMPGFYPSGRYDLAGFCVAVVEEEQLIDGRQIRAGDRILGIASSGIHSNGFSLVRRVLTHAGANAETTFGPSNQPLIESLLTPTQLYGRLVKTLLETGTPIHGMAHITGGGLPENLPRCLPEGLQAIVTPSSWTRPAIYDWLQSHGDIPERDLWHTFNLGIGYCLIVPEEGVSIAEKACESEGMQAWTIGRIEASSGGDGKGSVLGLPA
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_TREPS
Sequence: MKDIRDFDSLQIKLASPDTIRAWSYGEVKKPETINYRTLRPEREGLFCERIFGTTKEWECFCGKFKSIRYRGVICDRCGVEVTHFKVRRERMGHIELATPVSHIWYYRCVPSRMGLLLDLQVIALRSVLYYEKYIVIEPGDTDLKKNQLLTETEYNDAQERYGGGFTAGMGAEAIRTLLQNLDLDALVAQLREKMMEKGAKSDKRLLRRIEIVENFRVSGNKPEWMILSVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVIHRNSRLIRLMELKAPDIIIRNEKRMLQEAVDALFDNSKRKPAIKGASNRPLKSISDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLWQCGLPTKMALELFKPFIMKKLVEKEIVSNIKKAKMLVEQESPKVFSVLDEVVKEHPVMLNRAPTLHRLGIQAFEPVLVEGKAIRLHPLVCKPFNADFDGDQMAVHVPLTQAAQMECWTLMLSNRNLLDPANGRTIVYPSQDMVLGLYYLTKERSLPEGARPRRFSSVEEVMMAAEKGVIGWQDQIQVRYHKCDGQLVVTTAGRLVLNEEVPAEIPFVNETLDDKRIRKLIERVFKRQDSWLAVQMLDALKTIGYTYATFFGATLSMDDIIVPEQKVQMLEKANKEVLAIASQYRGGHITQEERYNRVVEVWSKTSEELTSLMMETLERDKDGFNTIYMMATSGARGSRNQIRQLAGMRGLMAKPSGDIIELPIRSNFKEGLNVIEFFISTNGARKGLADTALKTADAGYLTRRLVDIAQDVVVNEEDCGTINGIEYRAVKSGDEIIESLAERIVGKYTLERVEHPITHELLLDVNEYIDDERAEKVEEAGVESVKLRTVLTCESKRGVCVCCYGRNLARNKIVEIGEAVGIVAAQSIGQPGTQLTMRTFHVGGTASSTTEENRITFKYPILVKSIEGVHVKMEDGSQLFTRRGTLFFHKTLAEYQLQEGDSVQVRDRARVLKDEVLYHTTDGQTVYASVSGFARIIDRTVYLVGPEQKTEIRNGSNVVIKADEYVPPGKTVATFDPFTEPILAEQDGFVRYEDIILGSTLIEEVNTETGMVERRITTLKTGIQLQPRVFISDESGNALGSYYLPEEARLMVEEGAQVKAGTVIVKLAKAIQKTSDITGGLPRVSELFEARRPKNAAVLAQISGVVSFKGLFKGKRIVVVRDHYGKEYKHLVSMSRQLLVRDGDTVEAGERLCDGCFDPHDILAILGENALQNYLMNEIRDVYRVQGVSINDQHIGLVVRQMLRKTEVVSVGDTRFIYGQQVDKYRFHEENRRVEAEGGQPAVARPMFQGITKAALNIDSFISAASFQETNKVLTNAAIAGSVDDLCGLKENVIIGHLIPAGTGMRRYRQVKLFDKNKRDLDVQMEEVIRRRKLEEEALAQAVAGMEGEPEGEA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: ENO_RHOMI
Sequence: MAISKIHSRYVYDSRGNPTVEVELTTEKGTFRSIVPSGASTGVHEALELRDGDKSKWLGKGVLKAVANVNDTIAPALIEANIDVADQAKIDEFLLKLDGTPNKAKLGANAILGVSLAAAKAGAAQKDVPLYKHIADISKAKEGKFVLPVPFQNVLNGGSHAGGDLAFQEFMIVPSGAPSFSEGLRIGSEVYHHLKSLTKKKYGQSAGNVGDEGGVAPDIKTAKEALDLIVSAIEAAGYTGQVDIAMDVASSEFYKDGLYDLDFKNPNSDKSKWITGPQLAELYEQLLNEYPIVSIEDPFAEDDWEAWSHFFSKVEGKTQIVGDDLTVTNPIRIKKAIETKAADALLLKVNQIGTLTESIQAANDSYAAGWGVMVSHRSGETEDTFIADLSVGIRSGQTKTGAPARSERLAKLNQILRIEEELGDKAIYAGKDFHKAHSL
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIND_ECOLI
Sequence: MNEHHQPFEEIKLINANGAEQWSARQLGKLLGYSEYRHFIPVLTRAKEACENSGHTIDDHFEEILDMVKIGSNAKRALKDIVLSRYACYLVVQNGDPAKPVIAAGQTYFAIQTRRQELADDEAFKQLREDEKRLFLRNELKEHNKQLVEAAQQAGVATATDFAIFQNHGYQGLYGGLDQKAIHQRKGLKKNQKILDHMGSTELAANLFRATQTEEKLKRDGVNSKQQANTTHFDVGRKVRQTIQELGGTMPEELPTPQVSIKQLENSVKITEKK
What are the official names of this protein?
DNA damage-inducible protein D.
Protein: WASH1_MOUSE
Sequence: MTPVKTQCSLAGQLYAVPLIQPDLRREEAIQQVADALQYLQNISGDIFSRISRRVELSRRQLQAISERVSLAQAKIEKIKGSKKAIKVFSSAKYPAPEHLQEYGSIFTGALDPGLQRRPRYRIQSKHRPLDERALQEKLKYFPVCVNTKSEPEDEAEEGLGGLPSNISSISSLLLFNTTENLYKKYVFLDPLAGAVTKTHTMLGTEEEKLFDAPLSISKREQLERQAPENYFYVPDLGQVPEIDVPSYLPDLPGVADDLMYSADLGPGIAPSAPGAIPELPAFHTEVAEPLQPELENEVLLAAPPPPPPPPPPPPPAPTALVSTPQPPMFPDMATAAGQVAREEDSSSSMAHTASVQGAPKEVVDPSSGRATLLESIRQAGGIGKAKLRSVKERKLEKKKQKEQEQVRATSQGGDLMSDLFNKLVMRRKGISGKGPSTGTSEGPGGAFSRMSDSIPPLPPPQQPAGDEDEEDWES
What is the function of this protein?
Acts as component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875).  Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305).  In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function (PubMed:23275443).  In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (PubMed:24886983).  Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation (PubMed:24998208).  Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (PubMed:19732055).  Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity).  Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (PubMed:23974797).
What are the official names of this protein?
WASH complex subunit 1, WAS protein family homolog 1.
What is the protein family that this protein belongs to?
Belongs to the WASH1 family.
What are the subcellular locations of this protein?
Early endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, autophagosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2 (By similarity). Localized to Salmonella typhimurium entry sites (PubMed:19732055).
Protein: YCIB_SHIB3
Sequence: MKQFLDFLPLVVFFAFYKIYDIYAATAALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLGKELTLPQPVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CS044_HUMAN
Sequence: MASARKASRPMRDVFGDFSDVSLEDSTMEEIRNFQISRNLTKIAPGHSRFLKRNQTLDEKHLLLKENPVLGSGPRLASCRPPTTASRIRANAALMKLAQLETRIMNRKLQRNLSDTESDSMTADAGLPKRADRILSGGALELASQNTDKTSQNQARELPVTENNAQNAKVSRFLKKKQAPVENISPEAPAGKERTLQTPKQKEPARTFDSPDSDEEEMKVLLGSLMDSSREKNTNQGFSSANVSEEEERKLFSVPSQLRAFTVPSVELSSAKPSQTSHLPTSLAADRTLHSTRSRADYPQSHVSSDTASHTPSVSITGAFSNSVSLKMGHVKLVSSPGRSEAETVDEPVSEGADDSLDEFRINILSLDGLAPAVSENSDLEQEEESAQRQKTAGKIFRAEASTGQDAPRQAQARSWASQGKAASAEGDESEVSEHLSASSASAIQQDSTSSMQPPSEAPMVNTVSSAYSEDFENSPSLTASEPTAHSKESLDRTLDALSESSSSVKTDLPQTAESRKKSGRHVTRVLVKDTAVQTPDPAFTYEWTKVASMAAMGPALGGAYVDPTPIANHVISADAIEALTAYSPAVLALHDVLKQQLSLTQQFIQASRHLHASLLRSLDADSFHYHTLEEAKEYIRCHRPAPLTMEDALEEVNKEL
What are the official names of this protein?
Uncharacterized protein C19orf44.