PharMolix/UniProtQA huggingface dataset:
Protein: SSP1A_CAEEL
Sequence: MAELQFPGVYVEDVGHLAFGTLKLTEKSLNFKGDKGGKSVNVTGSDIDKLKWQKLGNKPGLRVGLNDGGAHRFGGFKDTDLEKIQSFTSSNWSQSIDQSNLFIKGWNYGQAEVKGKTVEFSWEDKPIFEIPCTNVSNVIANKNEAVLEFHQNDDSKVQLMEMRFHMPIDLENEEDADKVEEFKKAVLAYAGLEAETEQPICLLTDILCTTPRGRYDIKVYPTSIALHGKTYDYKIPIKSINRLFLVPHKDGRHVYFVLSLNPPIRQGQTRYSYLIFEFGKDEEQDLELALTDEQLESSNGNLRRDMTGPIYETISILFKSICNLKITVPGRFLGSSGTPAIQCTHRQNPGLLYPMEKGFLFIHKPAMYIRFEEISSCHFARSDSGTVTRTFDFEIDLKYGGPLTFNAMEKEENNKLFDYLNKKNIKIRNSQRVENTVADSSDDEIDPYKAAVTAEGRQRDDSDDDSTDEDYDLDKDIKKKKEDKESSEGTGSEPDDEYDSGSEQDSSGTGESEPDSEQDVPSKRRKGEPKEKREKKEKREKKEGKKGKKDKDPNAPKRATSAYMQWFLASRNELKEDGDSVADVAKKGGAKWKTMSSDDKKKWEEKAEEDKSRYEKEMKEYRKNGPPSSSSKPSSSKTSKKSSGPSSSKAISKEYISDSDDSDDEEPKKKEKKAAPKEESEESNNGSDGSDESDDSD
What is the function of this protein?
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.  It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.  Binds specifically to double-stranded DNA (By similarity).  In embryos, may function redundantly with hmg-3 in embryos to promote cell cycle progression and development of the anterior pharynx (PubMed:30336114).  In the germline, acts non-redundantly with hmg-3 to play a role in oocyte development (PubMed:30336114).
What are the official names of this protein?
FACT complex subunit SSRP1-A, Facilitates chromatin transcription complex subunit ssrp1-A, HMG box-containing protein 4, Structure-specific recognition protein 1-A.
What is the protein family that this protein belongs to?
Belongs to the SSRP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DNLJ_MARN8
Sequence: MTNVPETIRKRVDSLRATLEDHNYYYYVQDDPRIPDAEYDRLFRELQKLEAEHPELATEDSPTRRVGSSAETSFEEVIHRLPMLSLDNAFSEDELRDFDRRVRDRLGADGAIEYVCEPKLDGLAVSLHYENGTLTRAATRGDGYTGEDITANIRTIPSVPLKLRGSGYPDLVEVRGEVYMPRAGFEKLNERLAEQGEKTFVNPRNAAAGSLRQKKSTVTARRPLELCAYSMAVTDESVLPETHWDSLQLVRDWGFRINPEMRKAEGVEACLDAYNELMAKRDSLPYEIDGIVFKVNRLDLQQELGFVSRAPRWAIAHKFPAQEELTIIEDVEFQVGRTGAVTPVARLKPVFVGGVTVSNATLHNMDEIRRLDVHIGDTVFIRRAGDVIPQVVKVVPEKRPAEAPMVEMPEHCPVCGSDIVQIEGEAVARCSGGLYCPAQRKEAIRHYASRKAMDIEGLGDRLIEVLVDEGMVSTVADLYRLTKFQIASLERMGDKSAANLIAAIDRSREPVLWRFLYALGIREVGEATAKGLAAHFGTLEAISAADEETLQTVPDVGPIVAGHIRSFFDQPHNQETLAALKEAGVTWQEEQVLSADEQPLNGQTWVLTGTLSGMTRDQAKEKLEQLGAKVAGSVSKKTACVVAGEAAGSKLAKAEQLGVPVLDEEGLANLLREHGIEV
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: VE4_HPV39
Sequence: MANREVPVTDRYPLLNLLPNYQTPPRPIPPQQPHAPKKQSRRRLESDLDSVQSQSPLSPTECPWTILTTHSTVTVQATTQDGTSVVVTLRL
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: AGRB_STAA2
Sequence: MNYFDNKIDQFATYLQKRNNLDHIQFLQVRLGMQIIVGNFFKILVTYSISIFLSVFLFTLVTHLSYMLIRYNAHGAHAKSSILCYIQSILTFVFVPYFLINIDINFTYLLALSIIGLISVVIYAPAATKKQPIPIKLVKRKKYLSIIMYLLVLILSLIIHPFYAQFMLLGILVESITLLPIFFPKED
What is the function of this protein?
Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP).  This quorum sensing system is responsible for the regulation of the expression of virulence factor genes.  Involved in the proteolytic processing of AgrD, the precursor of AIP.
What are the official names of this protein?
Accessory gene regulator protein B.
What is the protein family that this protein belongs to?
Belongs to the AgrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: V2R_RAT
Sequence: MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
What is the function of this protein?
Receptor for arginine vasopressin.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1534150).  Involved in renal water reabsorption (By similarity).
What are the official names of this protein?
Vasopressin V2 receptor, V2R, AVPR V2, Antidiuretic hormone receptor, Renal-type arginine vasopressin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YPU1_RHOCA
Sequence: MRVLPLPLLIALGFPAAALAGNQTADCMAQATTPAEQLACVGKSSEACRSHLVDAQPALVAGCITDEVGWWRHRLMDAEAAMQARAEKLDVPYTKQIAEGAPRLTDDFEAMRKAWASWAEKRCTFEAMAHRNSPRRMVYAIDCHLHLTAEQALYLEAAAKGK
What are the official names of this protein?
Uncharacterized 17.7 kDa protein in puhA 5'region, ORF162A.
Protein: PAT13_MOUSE
Sequence: MFQKLLLSVFIILLMDVGERVLTFNLLRHCNLCSHYDGFKCRNGMKSCWKFDLWTQNRTCTTENYYYYDRFTGLYLFRYAKLNCKPCAPGMYQMFHDLLRETFCCIDRNYCNDGTANLDTSSILIEDMNQKKELNDD
What are the official names of this protein?
Prostate and testis expressed protein 13, Prostate and testis expressed protein X.
What is the protein family that this protein belongs to?
Belongs to the PATE family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLSA_ALIF1
Sequence: MKPTKQILEDILDEVRPLIGQGKVADYIPALACVPNDKLGIAVFTNDGEMLTAGDATECFSIQSISKALSLTLAMELYQPEELWQRVGKEPSGQAFNSLIQLEMEQGVPRNPFINAGAIVISDMLYSRFSAPKHRLLEFVRKLSGNDHIIYDRVVANSEMDHSDRNASIAYLMRSFGNFDNEVMPVLKNYFHACALSMNCVDLARTFGYLANKGIQPGISEPIVTPMQCKQINALMATCGLYDGAGEFAYRVGMPGKSGVGGGIIAIVPGEMTIAVWSPELDPSGNSLAGTKALELLSERIGRSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: PSBE_PROM9
Sequence: MIMAAGSTGERPFFEIITSIRYWIIHAVTLPAIFIAGFLFVYTGLAYDAFGTPRPDSYFQSSESKAPVVTQRYEAKSQLDLRTK
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RRF_STRPG
Sequence: MANAIIETAKERFAQSHQSLSREYASIRAGRANASLLDRIQVDYYGAPTPLNQLASITVPEARVLLISPFDKSSIKDIERALNASDLGITPANDGSVIRLVIPALTEETRKELAKEVKKVGENAKIAIRNIRRDAMDDAKKQEKAKEITEDELKTLEKDIQKATDDAIKEIDRMTAEKEKELLSV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OLA1_XENTR
Sequence: MPPKKADDGPKQHPIIGRFGTSLKIGIVGLPNIGKSTFFNVLTKSQAAAENFPFCTINPNESRVPVPDERFEFLCQYHKPASKVPAFLNVVDIAGLVKGASTGQGLGNAFLSNISACDGIFHLMRAFDDDDIIHVEGSVNPVRDIEIIHEELRLKDEEMIIAALDKLEKVAVRGGDKKLKPEYDIMCKVKNWIIDEKNHVRFYHDWNDKEIDVLNKYLFLTSKPMIYLVNLSEKDYIRKKNKWLIKIKEWVDKYDPCALVIPFSGVLELNLQDMSDEEKHKYLQEKVTQSVLSKIVKTGYAALQLEYFFTAGPDEVRAWTIKKGTKAPQAAGKIHTDFEKGFIMAEVMKFDDFKEEGSESSVKAAGKYRQQGRNYTVEDGDIIFFKFNTPQQSKKK
What is the function of this protein?
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency.  Has lower affinity for GTP.
What are the official names of this protein?
Obg-like ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm.
Protein: GRAP1_MOUSE
Sequence: MAQALSEEEFQRMQTQLLELRTNNYQLSDELRKNGVELSSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQLEQLELENRQLKEGVPGAAGAHVDGELLRLQAENTALQKNMAALQERYGKEAVRPSAVGEGQGDPPGDVLPTPLAPMPLAEVELKWEMEREEKKLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADLKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQIQTAKTQELNMLREQTSELASELQHRQAEYEELMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQDLQEARKSAEKRKVMLDELAMETLQEKSQHKEELGAVRLRHEKELLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELENLQHTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEETLKLCREEHAAELKGKDEELQNVREQLQQAQEERDGHVKTISNLKQEVKDTVDGQRILEKKGSAVLKDLKRQLHLERKRADKLQERLQEILTNSKSRTGLEELVLSEMNSPSRTQTGDSSSVSSFSYREILKEKESSAIPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGSPDPDLEPGEAN
What is the function of this protein?
Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity (By similarity).
What are the official names of this protein?
GRIP1-associated protein 1, GRASP-1, HCMV-interacting protein.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, dendrite. Synapse. Note=Localizes to recycling endosomal tubules that are emanating from early endosomes.
Protein: BHLHM_PEA
Sequence: MTAPTPENGCNKLQNMLQAAVQSVQWTYSLFWQICPQQLILVWGDGYYNGAIKTRKTVQPMEVSAEEASLQRSQQLRELYESLSAGETNPPTRRPCASLSPEDLTESEWFYLMCVSFSFPPGVGLPGKAYARRQHVWLTGANEVDSKTFSRAILAKSANIQTVVCIPVLDGVVEIGTTDKVQEDLNFIKHVRSFFIDHHSLPPKPALSEHSTSNPTYSTDHIPAIMYTVADPASTTIPNQDDMDEDEEEDDEDDEVESGSEDETNQGHNQHATSIIEAAEPSELMQIEMPDDIRIGSPNDGSNNLDSDFHLLAVSNQGNPSRQIDSYTTERWGPIEEPLDDSLQVQLSSSDKSYFIIH
What is the function of this protein?
Non-functional truncated transcription activator.
What are the official names of this protein?
Truncated basic helix-loop-helix protein A.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family.
Protein: NAGB_STRPN
Sequence: MKVIKVENQVQGGKVAFEILKEKLANGAQTLGLATGSSPLEFYKEIVESDLDFSNLTSVNLDEYVGLDGDNPQSYRYFMQENLFNQKPFKESFLPRGVKDNAEAEVERYNQILADHPVDLQILGIGRNGHIGFNEPGTPFDSQTHLVELDQSTIEANARFFAKIEDVPTQAISMGIKNILDAKSIILFAYGESKAEAIAGTVSGPVTENLPASSLQNHPDVTIIADAEALSLL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: FABH_PSEAE
Sequence: MPRAAVVCGLGSYLPEAVLSNDMLAAELDTSDAWISSRTGVRQRHIAGDLGSGDLALRAASAALASAGLERVDAVVLATSTGDFCCPATAPRVAARLGLVGALAFDLSAACTGFVYGLASVGSLISAGLADSALLVGVDTFSHTLDPADRSTRALFGDGAGAVVLRAGDAEEEGALLAFDLGSDGHQFDLLMTPAVSRAERSSGQASNYFRMDGKAVFGQAVTQMSDSVRRVLDRVGWQASDLHHLVPHQANTRILAAVADQLDLPVERVVSNIAEVGNTVAASIPLALAHGLRQGILRDGGNMVLTGFGAGLTWGSVALRWPKIVPTMD
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_FRAT1
Sequence: MSNAREIRSKVQSVKNTQKITGAMELVAASKMRGAIVKMNNVRPYVESANTIIKNVTAASIDYPNPYLFDRDVKRVGYIVISTDRGLCGGLNINLFKHVLKEIKNNIEDRVGVDVCVIGSKAENFFAKLKDVNIVATAHYNDKDKEGSIRAIGGAVKVMLDKFTAGEIDRLYMSSNQFVSTIKQRPRLQTLLPIQDIFSAEEIKANKEKATKGHWDYIYERDIEEVLNALFIRYIEAQVRGAILENAACEQAARMMAMKNATDNASDIIDQLKLDYNKVRQAMITQELAEICSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL3_UREPA
Sequence: MKSLLGTKVGMTQVFTETGKAVAATVIYVEPNKVLAVKTNEKDGYSAIQIGYETVKEKALNKPLLGQFKKANSDPKRHIKEFRDVVAEVGAELTVSEFEPGQLVNAQAYTKGHGFTGSIKRHNFSMGPMGHGAGYPHRYVGSIAKGRGGSQAQRVFKGTKLPGHYGHELVTTKNLLVLDVKANENLILIKGAIPGPKGSIVLLKSAKKVGHIVSDPQVVNYLANKASSSEANE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: MURC_STRT2
Sequence: MQGETMSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGIPILPFDEKNITEDVELIAGNAFREDNNVEIAYAIKNGYKFKRYHEFLGHFMNQFTSFGVAGAHGKTSTTGLLSHSMKNITDTSYLIGDGTGRGSANAQYFVFEADEYERHFMPYHPAYSIITNIDFDHPDYFTSIDDVFSAFDDYAKQVQKGLFVYGEDSNLRKITSNAPIYYYGFEENDDFMATDIIRTTTGSNFKVKHDGQIIGEFHVPAYGRHNILNATAVIANLYVAGFDMALVAEHLKTFSGVKRRFTEKIISDTVIIDDFAHHPTEIIATLDAARQKYPSKEIVAIFQPHTFTRTIALLDDFAEALNEADAVYLAQIYGSAREVDHGDVKVEDLAAKINKPAKVVTVENVSPLLDHDNAIYVFMGAGDIQLYERSFEELLASLQTHM
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTND_ECOLI
Sequence: MVDTTQTTTEKKLTQSDIRGVFLRSNLFQGSWNFERMQALGFCFSMVPAIRRLYPENNEARKQAIRRHLEFFNTQPFVAAPILGVTLALEEQRANGAEIDDGAINGIKVGLMGPLAGVGDPIFWGTVRPVFAALGAGIAMSGSLLGPLLFFILFNLVRLATRYYGVAYGYSKGIDIVKDMGGGFLQKLTEGASILGLFVMGALVNKWTHVNIPLVVSRITDQTGKEHVTTVQTILDQLMPGLVPLLLTFACMWLLRKKVNPLWIIVGFFVIGIAGYACGLLGL
What is the function of this protein?
Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA.
What are the official names of this protein?
PTS system mannose-specific EIID component, EII-M-Man, EIID-Man, Mannose permease IID component.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EPID_STAEP
Sequence: MYGKLLICATASINVININHYIVELKQHFDEVNILFSPSSKNFINTDVLKLFCDNLYDEIKDPLLNHINIVENHEYILVLPASANTINKIANGICDNLLTTVCLTGYQKLFIFPNMNIRMWGNPFLQKNIDLLKNNDVKVYSPDMNKSFEISSGRYKNNITMPNIENVLNFVLNNEKRPLD
What is the function of this protein?
Catalyzes the removal of two reducing equivalents (oxidative decarboxylation) from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond.
What are the official names of this protein?
Epidermin decarboxylase, Epidermin-modifying enzyme EpiD.
What is the protein family that this protein belongs to?
Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.
Protein: PFD2_RAT
Sequence: MADSSGRVGKSGGSGTGKGAVSAEQVIAGFNRLRQEQRGLASKAAELEMELNEHSLVIDTLKEVDETRKCYRMVGGVLVERTVKEVLPALEGNKEQIQKIIETLSQQLQAKGKELNEFREKHNIRLMGEDEKPAAKENSEGAGAKSSSAGVLVS
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
What are the official names of this protein?
Prefoldin subunit 2.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Mitochondrion.
Protein: 8ODP_CANLF
Sequence: MGTSRLYTLVLVLQPERVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGAKRELREESGLTVDTLHKVGQIMFEFVGEPELMDVHIFCTDSVQGTPVESDEMRPQWFQLDQIPFTDMWPDDSYWFPLLLQKKKFHGYFRFQGPNTILDYTLREVDKL
What is the function of this protein?
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:30304478, PubMed:32144205, PubMed:29281266).  Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (By similarity).  Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:30304478, PubMed:32144205, PubMed:29281266).  Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:30304478, PubMed:32144205, PubMed:29281266).  Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205).  Through this antimutagenic activity protects cells from oxidative stress (PubMed:30304478, PubMed:32144205, PubMed:29281266).
What are the official names of this protein?
Oxidized purine nucleoside triphosphate hydrolase, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, Methylated purine nucleoside triphosphate hydrolase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus membrane. Cytoplasmic vesicle, secretory vesicle, acrosome.
Protein: YBIX_ECOLC
Sequence: MMYHIPGVLSPQDVARFREQLEQAEWVDGRVTTGAQGAQVKNNQQVDTRSTLYAALQNEVLNAVNQHALFFAAALPRTLSTPLFNRYQNNETYGFHVDGAVRSHPQNGWMRTDLSATLFLSDPQSYDGGELVVNDTFGQHRVKLPAGDLVLYPSSSLHCVTPVTRGVRVASFMWIQSMIRDDKKRAMLFELDNNIQSLKSRYGESEEILSLLNLYHNLLREWSEI
What are the official names of this protein?
PKHD-type hydroxylase YbiX.
Protein: GRPE_VIBHA
Sequence: MSNEENKVTEEELDQIIEEAEKVEAAAQEAEAELEEIGDEKDAKIAQLEAALLSSETKVKDQQDAVLRSKAEVENMRRRTEQEIDKARKYALNKFAEELLPVIDNLERAIQAADAEHEVVKPILEGVELTHKTFVDAVSKFGLKEINPEGEAFNPEFHQAMSIQESPDHESNTVMFVMQKGYELNGRVVRPAMVMVAK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACG_STAA8
Sequence: MTKTLPEDFIFGGATAAYQAEGATNTDGKGRVAWDTYLEENYWYTAEPASDFYNRYPVDLELSEKFGVNGIRISIAWSRIFPNGYGEVNPKGVEYYHKLFAECHKRHVEPFVTLHHFDTPEVLHKDGDFLNRKTIDYFVDYAEYCFKEFPEVKYWTTFNEIGPIGDGQYLVGKFPPGIKYDFEKVFQSHHNMMVAHARAVKLFKDGGYKGEIGVVHALPTKYPFDPSNPEDVRAAELEDIIHNKFILDATYLGKYSRETMEGVQHILSVNGGKLNITDEDYAILDAAKDLNDFLGINYYMSDWMRGYDGESEITHNATGDKGGSKYQLKGVGQREFDVDVPRTDWDWMIYPQGLYDQIMRVVKDYPNYHKIYITENGLGYKDEFIESEKTVHDDARIDYVRQHLNVIADAIIDGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWYKELAETKEIK
What are the official names of this protein?
6-phospho-beta-galactosidase, Beta-D-phosphogalactoside galactohydrolase, PGALase, P-beta-Gal, PBG.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: NO66_DROMO
Sequence: MDRISAYAAYGLAPKKTSKRSTMKIAKHFSKKNAKKTKEAMAAKKEARKAAAKAALREVRKLERKAAADKAAKIAADKAADKAAAKAAAKAAKKAAKREKNIAKKQPEKSAAGVTENVQKQLENGQENNGTLINLSNGKQHQKPKAAKMSSSNGSFSGIDSDFLNSSDFGSTEDSFMSGSGDSFDYSNNSDFDFDSDGDSNDFDDSDAAASSCASCEYFDMDSNMVVGQESDTNGNSYMHNGTTQSEDQFTEEYTLSSIFNSTSSSGANPIKVEPRKAAKRNEPFDLNNNKNKPTAAKQPKMSLKQEQAQVGKQRADPAPSCPLPPRPSKTMIKSCPLPPKAPAAKPVPNKCRLSSRESLTKTGAKSCRLSSAPADKMANKMAAPSRKSSSKNKNNDNNNIDTNNKKDANNKKDANNNKDINNKKDANNNKDTNNNKDNNNKNKLSSNVSQLVTGNEKQRGPVHLENSIEEGKRMLNWLLNPITSETFFEQYWERNACQVKRKQPNYFTQLISFQMIDEMLIENQLEFTTNIDVTTYKKGVRQTLNPVGRAMSPAIWGYYGDGCSIRILNPSTYLPKLRQLCSTMQEFFHCLVGANVYLTPPNSQGFAPHYDDIEAFVIQVEGRKRWRLYAPPHQSDVLARTSSGNYKQEELGQPLFDAVLEAGDILYFPRGTVHQAVTEPKQHSLHITLSVYQQQAYANLLEVLMPSVLERAIKHHLSLRRGLPLHIWQHVGLAKGGQQSEQRDQLMNSTKQLVQRYLVPTEAQIDAAVDQLAKRFQHEALPPYIKPEESMRTTKVRLLRRQHPAPGGRRQQLRVYYYVDNALEYCKNEPNYMEIQPTEAPAVEALMTTYPAYLKVGKLPLRSADRRIEVATALWERGLLMTEKPFK
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
What are the official names of this protein?
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Histone lysine demethylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus.