PharMolix/UniProtQA huggingface dataset:
Protein: ORC4_DICDI
Sequence: MSNIDETENQEYLLLKAKNIITERTQSSYLPDEYIGAEKEAETLYAILDDAIINKKSTVGLITGPKGSGKSSFFKHCLKKYNESDYLLVRLSGMIHFNDNYALKEIAKALGIKIPSGLNIFHTFEFIRVKLGKETLESQINTSTKKIQFQSLPVVILIEELELMLTSLSTSKQSLFYNLLDLSHYKNVSLSFIATTSQHDIVNMFEKRIKSRFTQESIKIPPLSFDSIQIIFKNLISLPESFDDEEYRDTWNANVEKSLKSTSVIENFKKYYRLYNRVNNYHLLVNEIIDNLDYYDKDNKWINSKIINDGFEYLNQDVIEIMLKSLSVLEFTILGCILNTKVGTNINDDYITFDELYDGEYKKLSYSFFKNVDQAKKPSTIRILQHLLLLGIIKTQSRANDSGDFPKFKIAIDPDSIINAAKNRNDLPTVIVKYVTEWLT
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
What are the official names of this protein?
Origin recognition complex subunit 4, Origin replication complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the ORC4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUOA2_PSEA7
Sequence: MHGILSPGAWAFIAYVLGAVALCLVMLGLGRVLGGRSHGRAKNLPFESGVDSTGSARLRFPVKYALVAMLFVIFGIEMPFLYLWAVSVRENGWAGFVEVALFVSLLLAGLFYLHRVGALDWSPERRRRKPRD
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A 2, NADH dehydrogenase I subunit A 2, NDH-1 subunit A 2, NUO1 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y5895_HAHCH
Sequence: MPFKRLIKSIDIGRAAESQAEKFARAQGFTIVERNFRCKGGEIDLIARHGEHLVFIEVRHRSSDKFGSAAESITQKKQQRIILAANIYLQKKGLTNMPCRFDVIVGNLKSNTGFQWIPDAFSCW
What are the official names of this protein?
UPF0102 protein HCH_05895.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: MYC_AVIM2
Sequence: MPLSASLPSKNYDYDYDSVQPYFYFEEEEENFYLAAQQRGSELQPPAPSEDIWKKFELLPTPPLSPSRRSSLAAASCFPSTADQLEMVTELLGGDMVNQSFICDPDDESFVKSIIIQDCMWSGFSAAAKLEKVVSEKLATYQASRREGGPAAASRPGPPPSGPPPPPAGPAASAGLYLHDLGAAAADCIDPSVVFPYPLSERAPRAAPPGANPAALLGVDTPPTTSSDSEEEQEEDEEIDVVTLAEANESESSTESSTEASEEHCKPHHSPLVLKRCHVNIHQHNYAAPPSTKVEYPAAKRLKLDSGRVLKQISNNRKCSSPRTSDSEENDKRRTHNVLERQRRNELKLSFFALRDQIPEVANNEKAPKVVILKKATEYVLSIQSDEHRLIAEKEQLRRRREQLKHKLEQLRNSRE
What is the function of this protein?
Transforms avian and murine macrophages and fibroblasts as well as murine B-lymphoid cells.
What are the official names of this protein?
Viral myc transforming protein, v-Myc.
What are the subcellular locations of this protein?
Host nucleus.
Protein: PCRB_ANOFW
Sequence: MNEITTWRHVFKLDPNKEITDEQLEQVCESGTDAIIVGGTDGVTLENVIDLLARVRRFSVPCALEVSDIEAITPGFDYYFIPMVLNSRDLTWLIDLHHEAVKQFGDLINWEELFVEGYCILNDECKAASLTSARTNVTEEDVIAYARMAEHMYHFPIFYMEYSGRYGDVALVEKVKRTLERTRLFYGGGIHTPEQAKEMAMWADTVVVGNAIYTNLQMALQTVEAVKGKSA
What is the function of this protein?
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP).  This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.
What are the official names of this protein?
Heptaprenylglyceryl phosphate synthase, HepGP synthase, Glycerol-1-phosphate heptaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
Protein: RNH2_MAGSA
Sequence: MPDLALEFEIGGIVCGIDEVGRGPLAGPVVAAAVILDPARLPKTLLERLDDSKKLSKRNREELAELVPATAILGFGEASVEEIDRINILQATFLAMRRAYDALGRECAHALVDGNRPPGLPCPVRCVVGGDGISLSIAAASVVAKVRRDAMMADLARAHPEFGWERNAGYGTAEHLDALKRLGPTPHHRRSFAPVAQYMLF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_BUCA5
Sequence: MKGGKRVQLTRPNRINSEIRAIKVRLTGVEGDQIGIVNLREALKKSEELGLDLVEISPNAEPPVCRIMDYGKFLYEKSKSSKEQKKKQKVIHIKEIKFRPGTDEGDYQVKLRNLIRFLEDGDKAKITLRFRGREMAHQKIGVDVLNRVKNDLIELATVEYFPSKIEGRQMIMILAPKKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VOPP1_MOUSE
Sequence: MGRRLGRVAALLLGLLVECTEAKKHCWYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFLLMMGVLFCCGAGFFIRRRMYPPPLIEEPTFNVSYTRQPPNPAPGAQQMGPPYYTDPGGPGMNPVGNTMAMAFQVQPNSPHGGTTYPPPPSYCNTPPPPYEQVVKDK
What is the function of this protein?
Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
What are the official names of this protein?
Vesicular, overexpressed in cancer, prosurvival protein 1, EGFR-coamplified and overexpressed protein, ECop.
What is the protein family that this protein belongs to?
Belongs to the VOPP1/ECOP family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions.
Protein: UPPP3_ACIAD
Sequence: MGNIEAFKALFLGFIEGLTEFLPISSTGHLILFGHLIDFHSDSGRAFEVVIQLGAILAVCWLYRKKIIDLVQGFFSGDQEARHFTFSVLMAFFPAVIIGVLAVDFIKSVLFSPLVVAIALIIGGLIIFWVESRDFKPSTTEATKITFKQAIAVGFIQCLAMIPGTSRSGATIIGGMLSGLSRKAATEFSFFLAMPTMLGAATYDLLRNADVLTSDNMLNIGLGFITAFISALFVVKALVRFVEKHTLRVFAWYRIVLGIIIMFVML
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 3, Bacitracin resistance protein 3, Undecaprenyl pyrophosphate phosphatase 3.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GUAA_SYNS9
Sequence: MSQPSSDGQRQPAIVILDFGSQYSELIARRVRETEVFSVVIGYSTTADELRRMAPKGIILSGGPSSVYAEHAPVCDPAIWDLGIPVLGVCYGMQLMVQQLGGAVEAATGKAEYGKAPLEVDDPTDLLNNVENGSTMWMSHGDSVKALPEGFVRLAHTANTPEAAVANLERKFYGVQFHPEVVHSTCGMALIRNFVNHICGCEQDWTTNAFIDEAVALVREQVGQKRVLLALSGGVDSSTLAFLLKKAIGDQLTCMFIDQGFMRKGEPEFLMEFFDQKFNINVEYINARKRFIDKLKGITDPEDKRKIIGTEFIRVFEEESKRLGPFDYLAQGTLYPDVIESAGTNVDPKTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRKVGRNLGLPEEIVRRHPFPGPGLAIRILGEVTDEKLNCLRDADLIVREEIRDAGLYHDIWQAFAVLLPVRSVGVMGDQRTYAWPIVLRCVSSEDGMTADWSRLPYDLMERISNRIVNEVKGVNRVVMDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: ALF_SHIFL
Sequence: MSKIFDFVKPGVITGDDVQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKSDVPQGAAILGAISGAHHVHQMAEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHFAATGKPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCTGGEEDGVDNSHMDASALYTQPEDVDYAYTELSKISPRFTIAASFGNVHGVYKPGNVVLTPTILRDSQEYVSKKHNLPHNSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEAYLQGQLGNPKGEDQPNKKYYDPRVWLRAGQTSMIARLEKAFQELNAIDVL
What is the function of this protein?
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
What are the official names of this protein?
Fructose-bisphosphate aldolase class 2, FBP aldolase, FBPA, Fructose-1,6-bisphosphate aldolase, Fructose-bisphosphate aldolase class II.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family.
Protein: SEPF_ALKCK
Sequence: MGFKTKFKRYFNLDDHVEEVERYVEEPEQRDERPALEKGRAPKEKQTAGMEQNQNIVSLQSVQKSAKMILLEPRSYDEAQDIADHLKRRKAVVINLLRIEQEQALRIVDFLSGTVYAIGGDIQKIGPGIFLCTPDNVEITGSISDWVTRQTDSTV
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: YRRT_HALH3
Sequence: MGVEFVDLFNQWASSYDDTVSGNDPEYKEVFEGYEDMLELLAGLSISPVMEFGVGTANLTRKMIGQNKVVIGIEPSSEMRRIANLKCPEAAIYDGDFLNYPQLITPIQSIVSSFAFHHLTTSEKIEAIQKFDDKLESKGKVIFIDTLFKDEAHKQALIKNAEKSGHLNLAQDLQEEYYGYLDELKEMFSNQGFEVSFKQINNYAWLIQAKKGE
What is the function of this protein?
Could be a S-adenosyl-L-methionine-dependent methyltransferase.
What are the official names of this protein?
Uncharacterized methyltransferase YrrT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. YrrT family.
Protein: BXL1_ARATH
Sequence: MSCYNKALLIGNKVVVILVFLLCLVHSSESLRPLFACDPANGLTRTLRFCRANVPIHVRVQDLLGRLTLQEKIRNLVNNAAAVPRLGIGGYEWWSEALHGISDVGPGAKFGGAFPGATSFPQVITTAASFNQSLWEEIGRVVSDEARAMYNGGVAGLTYWSPNVNILRDPRWGRGQETPGEDPIVAAKYAASYVRGLQGTAAGNRLKVAACCKHYTAYDLDNWNGVDRFHFNAKVTQQDLEDTYNVPFKSCVYEGKVASVMCSYNQVNGKPTCADENLLKNTIRGQWRLNGYIVSDCDSVDVFFNQQHYTSTPEEAAARSIKAGLDLDCGPFLAIFTEGAVKKGLLTENDINLALANTLTVQMRLGMFDGNLGPYANLGPRDVCTPAHKHLALEAAHQGIVLLKNSARSLPLSPRRHRTVAVIGPNSDVTETMIGNYAGKACAYTSPLQGISRYARTLHQAGCAGVACKGNQGFGAAEAAAREADATVLVMGLDQSIEAETRDRTGLLLPGYQQDLVTRVAQASRGPVILVLMSGGPIDVTFAKNDPRVAAIIWAGYPGQAGGAAIANIIFGAANPGGKLPMTWYPQDYVAKVPMTVMAMRASGNYPGRTYRFYKGPVVFPFGFGLSYTTFTHSLAKSPLAQLSVSLSNLNSANTILNSSSHSIKVSHTNCNSFPKMPLHVEVSNTGEFDGTHTVFVFAEPPINGIKGLGVNKQLIAFEKVHVMAGAKQTVQVDVDACKHLGVVDEYGKRRIPMGEHKLHIGDLKHTILVQPQL
What is the function of this protein?
Involved in pectic arabinan modification in mucilage secretory cells.  Acts also as a beta-D-xylosidase during the remodeling of xylans in vascular development.
What are the official names of this protein?
Beta-D-xylosidase 1, AtBXL1, Alpha-L-arabinofuranosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: ERL2B_XENLA
Sequence: MSHAGAIAALGVALIAAALFSAIHKIEEGHVGVYYRGGALLTTTSGPGFHLMLPFITSFKSVQSTLQTDEVKNVPCGTSGGVMIYFDRIEVVNYLISSAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHNLQEVYIELFDQIDEDLKLALQKDLNLMAPGIIIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKAIIEAEKVAQVAQIKYGQKVMEKETEKKISEIEDFAFLAREKARADAEYYTAQKAAEANKLKLTPEYLQLMKYQAIAANSKIYFGQDIPNMFMDSSSAGPRVQSAKRNEPAAAEELK
What is the function of this protein?
Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs).  Promotes sterol-accelerated ERAD of HMGCR.  Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (By similarity).
What are the official names of this protein?
Erlin-2-B, Endoplasmic reticulum lipid raft-associated protein 2-B, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2-B, SPFH domain-containing protein 2-B.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Protein: RRP3_NOSP7
Sequence: MTKFILKILWLDENVALAVDQIVGKGTSPLTKYFFWPRNDAWEELKKELESKHWITDLDRVELLNKATEVINYWQEEGRNRPMAEAQLKFPEVAFTGSA
What is the function of this protein?
Probably a ribosomal protein or a ribosome-associated protein.
What are the official names of this protein?
Probable 30S ribosomal protein PSRP-3, Ycf65-like protein.
What is the protein family that this protein belongs to?
Belongs to the chloroplast-specific ribosomal protein cS23 family.
Protein: KCNN1_MOUSE
Sequence: MSSHSHNGSVGQPLGSGPGFLGWEPVDPEAGRPLQPTQGPGLQMVAKGQPVRLSPGGSRGHPQEQEEEEEEEEEEDKTGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELVVCAIHPVPGHYRFTWTARLAFSLVPSAAEADLDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSVSSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQGRVRKHQRKFLQAIHQAQKLRSVKIEQGKVNDQANTLAELAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPGLIAQAICPLPPPWPGPGHLATATHSPQSHWLPTMGSDCG
What is the function of this protein?
Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:11557517).  Activation is followed by membrane hyperpolarization (PubMed:11557517).  Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (PubMed:11557517).
What are the official names of this protein?
Small conductance calcium-activated potassium channel protein 1, SK1, SKCa 1, SKCa1, KCa2.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PYRH_ZYMMO
Sequence: MYKRPRFNRVLLKLSGEVLMGPGQFGIDPATVARVADEIRAAREAGYQLCIVVGGGNIFRGLAATARGIERSSADYMGMLATVMNAIAVQNALENLGVDTRVQSAIPMPTVCEPFIRRRAERHMEKGRVVIFAAGTGNPFFTTDSGAALRAAEMKCDALFKGTSVDGVYDADPKKVKEARRYDCVSFNRVLADDLKVMDASATALCRDNNIPIVVFNIREQGNFSRVLKGDGVSTIVCNEEE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLPA_PYRNV
Sequence: MSIEVVEVRPHERHFGVYALKFEDGSERLATRNLTPGKRVYGERLVKWGGAEYREWNPYRSKLAAAIANGIKFVPIQEGTHILYLGAASGTTPSHMSDIVGERGLIYSVEFSPRVFREFMEKLVDQGRRNVVPILGDARFPYQYAHYVKGVDVAYIDVAQPAQAKILADNADYFLKPGGYVMLVIKAMSIDVTAPATETFKQEINTLKERGFEILETVHLEPYDTAHAMVVARKR
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: IF44L_HUMAN
Sequence: MEVTTRLTWNDENHLRKLLGNVSLSLLYKSSVHGGSIEDMVERCSRQGCTITMAYIDYNMIVAFMLGNYINLHESSTEPNDSLWFSLQKKNDTTEIETLLLNTAPKIIDEQLVCRLSKTDIFIICRDNKIYLDKMITRNLKLRFYGHRQYLECEVFRVEGIKDNLDDIKRIIKAREHRNRLLADIRDYRPYADLVSEIRILLVGPVGSGKSSFFNSVKSIFHGHVTGQAVVGSDITSITERYRIYSVKDGKNGKSLPFMLCDTMGLDGAEGAGLCMDDIPHILKGCMPDRYQFNSRKPITPEHSTFITSPSLKDRIHCVAYVLDINSIDNLYSKMLAKVKQVHKEVLNCGIAYVALLTKVDDCSEVLQDNFLNMSRSMTSQSRVMNVHKMLGIPISNILMVGNYASDLELDPMKDILILSALRQMLRAADDFLEDLPLEETGAIERALQPCI
What is the function of this protein?
Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity (PubMed:34722780).  During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion (PubMed:34722780).  Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate (PubMed:32611756).  Exhibits a low antiviral activity against hepatitis C virus (PubMed:21478870).  Acts also as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5 (PubMed:31434731).
What are the official names of this protein?
Interferon-induced protein 44-like.
What is the protein family that this protein belongs to?
Belongs to the IFI44 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNPA_BACFR
Sequence: MEIRKQYFKEKQYMWHKVRELQLKGLNKTQIGIYLGVNRKTVRRYLNMTMEEFVKKQSSHRKYRLKLENYEQYVRANLEEYPYISAARIHDWLKECYPDFPRVCNRTISGFVERVRKKYGIGKKVETHKRNYEKQPDTPYGEYAQADFGEKCMRTENGKSIKVYFFAIVLSRSRYKFIYFSRRPFDTGLAVYAHELAFEYFGGRPQKIIYDQDKVLIARANMGDLILTGKFQAFVKEQHFHPVFCHKADPESKGRVENVVKYVKTNFLTARIFQNVDRLNEEARLWLERTGNGKEYGTTHRIPLEEFAQEREYLVPYHGTPHSPGGEMKEYHVRKDNTVQYRGNYYSLPCGTYRGGETTVWLHETDGCLELYNKETGKLVCRHDLCELKGKTIYGEGHRRQRNIGAQKLAERILIYVSYNREVALWLENLQRRKERYYRENLEVILRIIPGYDKAILTEAVSVCLDKGIYNGESVKSLCGHIWKKKMRESDVGKNPASRTQSTGLVKTYNEIFRNNGKV
What is the function of this protein?
Involved in the transposition of the insertion sequence.
What are the official names of this protein?
Transposase for insertion sequence element IS21-like.
What is the protein family that this protein belongs to?
Belongs to the transposase IS21/IS408/IS1162 family.
Protein: CODY_CLOBM
Sequence: MSSLLDKTRMLNRILQKSGTEPVDFEDICDLLSDVLACNVYIISRKGKILGSKFYSGFECEEVREVVLKENRFPDFYNNKLLNVNETLSNSPNHDKCVFDNLKDCSINNKLSTIVPINGNRERLGTLLLARFDKEFTDEDLILAEYSATIIGLEILRSKQDQIEEEARKKAVVQLAIGTLSYSELEAVEHIFNELDGTEGLLVASKIADKVGITRSVIVNALRKFESAGVIESRSLGMKGTHIRILNDKLLEELKKIK
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_PECCP
Sequence: MATARQGENTISPEAIPSNLPSRPTVLVFDSGVGGLSVYDEIRQLLPDLHYIYAFDNEAFPYGEKSQQFIIERVVEIVNAVQLRHQLALVVIACNTASTISLPALRERFTFPVVGVVPAVKPAAKLTRNGVVGLLATRATVQRPYTHELIARFATDCQILSLGSSELVELAEAKLQGETISISELQKILRPWLRLPEPPDTVVLGCTHFPLLAEELKAALPDGTRLVDSGAAIARRTAWLIANLDNPPLSTDKNLVYCLAITPKVATLWPILQRYGFDSLEKLPL
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: ABNA_ASPCL
Sequence: MHPSTFVTTIACLAGLAHGYANPGSCSGACNIHDPALIRRQSDGKYFRFSTGNKISYASSSSIKGPWTVLGSVLPRGSSINLPGKTDLWAPDISLVNGAYHLYYSVSAFGSQDSAIGLATSATMDPNSWTDHGSTGIRSSSSKPYNAIDANLFHDGGNYYMTFGSFWHDIYQAPMNSAATAVSSGPYNIAYNPSGTHAVEGAFMYKFGKYYYLFFSSGICCGYDTSRPAAGKEYKIRVCRSTSATGHFVDKHGVSCTNGGGTVVLESHGHVYGPGGQGVFTDPALGPVLYYHYVDTRIGYADGQKRFGWNKIDFSSGWPVV
What is the function of this protein?
Endo-1,5-alpha-L-arabinanase involved in degradation of pectin.  Its preferred substrate is linear 1,5-alpha-L-arabinan (By similarity).
What are the official names of this protein?
Probable arabinan endo-1,5-alpha-L-arabinosidase A, Endo-1,5-alpha-L-arabinanase A, ABN A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 43 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPA_CALBD
Sequence: MNFIDERFERLKKEGKKAFIGYVTFGYPTFEETLWFIKLVYSYVDILEIGFPFSDPIADGEIIQKASIKALSEGVKLSHLFESIEKFKKDKPVVLMLYANTVYKRGIDRFFESCKACGVDGVIIPDVSFEESFEFKEVAEKFGIVYIDLVSISSLERAKMIGRQSRGFLYCVSRKGVTGFKGQIDDRIFTFLKELKTVTSTPLAVGFGIKSKEDVQKFKDLADGIVIGSAIITKIDEGKDKLEDFLKEISESLKDK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: PRDM4_PONAB
Sequence: MHHRMNEMNLSPVGMEQLTSSSVSNALPVSGSHLGLAASPTHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNASALDPYQSNGNVGLEPGIVSIDSRSVNTHGAQSLHPSDGHEVALDTAITMENVSRVTSPISTDGMAEELTMDGVAGEHSQIPNGSRSHEPLSVDSVSNNLAADAVGHGGVIPMHGNGLELPVVMETDHIASRVNGMSDSALSDSIHTVAMSTNSVSVALSTSHNLASLESVSLHEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVPPSLQMEDSNSNKENMATLFTIWCTLCDRAYPSDCPEHGPVTFVPDTPIESRARLSLPKQLVLRQSIVGAEVGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHNGVLEFCIITADENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIGVPEHPDVHLCNCGKECNSYTEFKAHLTSHIHNHLPTQGHSGSHGPSHSKERKWKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGKRDYVCEKCTKAYLTKYHLTRHLKTCKGPTSSSSAPEEEEEDDSEEEDLADSVGTEDCRINSAVYSADESLSAHK
What is the function of this protein?
May function as a transcription factor involved in cell differentiation.
What are the official names of this protein?
PR domain zinc finger protein 4, PR domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAP12_LACSX
Sequence: MKTRIFIGSSSEGIDVAKRIKTFFAPEYDCFLWTDDIFRNNESFLETLVKSASLFDFGFMVFSADDKTTIRDQHFESPRDNVLFEYGLFLGRVGLDRAFVIAETDAKIPTDMLGITQTRYETIVNSKGIKVATDSLESSLQKLKKQIDENVQLGHLGLLPSTVIAISYFEGFVKLAAEWLVENTPELMINNHKFNKASLKIVMPESLDTDIKRSAMMYYKRHGLEEARIDTKHRNYPIHFASKTEDGILEVYDMPTILTGIDKAIDMYFRVGHIGKTNEQKLAEDHEMNNFKRVLQLLINEDAFCRECVEIIEPQP
What is the function of this protein?
The effector protein for this CBASS system.  Binds c-di-GMP (synthesized by the cognate CdnE encoded upstream in the same operon) but not c-di-AMP, 2'-3'-cGAMP, 3'-3'-cGAMP or cUMP-AMP (tested without the N-terminal TIR domain) (PubMed:32877915).  Upon activation by c-di-GMP forms filaments which hydrolyze NAD(+); filament formation is required for enzyme activation (By similarity).
What are the official names of this protein?
CD-NTase-associated protein 12, Cap12, NAD(+) hydrolase, TIR-STING, LbSTING.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the bacterial STING family.
Protein: SYH_PYRNV
Sequence: MSGLPEHLRRPPRGMRDWLPPQLYALIEMEERLSKVAESFGYRRVETPVVEHFEVLAKKAGQEVVNEIYYFKDKAGRDVGLRFDMTVPVARVISYNLDLPRPVRWYYFTKVFRYDEPQHGRYREFHQFGIELVGSASPRADAEVIQVFIEALEAAGARDYVVKINDRRAVDKLLESLGVLQHRDVIYRALDKKYKLPREQVVDIMTNGGVPIDKAERIYDASEEMTLEEAVDAVLRLDAGLGSFYQKLVGYLATAVPVDRLRFDMSIVRGLDYYTGVVFEAYVGKYRLAVGGGGRYDDLLELYSGVKMPALGFAIGVERLMEAVGLERVEKPLDYYIYIFDDGAYPHAVALAKKLRAAGHSVAIELGEKNLKDAFEYILKVGTKYLIIMGRRELERGVVKIRDLQRREEFEKPLAEF
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VBET_BPP4
Sequence: MKVYFENYSYYPALRTRSAEMTGLNNLSYENKKKILPLISLGKWPRSEEIQVSLDKSLEVMSNLPFILDVTKDNSHHCASSFELLSPENGFKNWIEFCSRNDNIIPVVQMPDSAKLRDISIQARVLEELKGSIAFRIRNLNTDINKTLTSLVSMNSPENAIVFIDLGYIRGNVSAITAAAINSINQIRTEIPEAIISVLATSFPSSVTNFCRENGQSGYIDVIERELHQNIGGSDVAIYGDHGSIHSVVYDNIIGRYVPRIDIALNDSWYFERRPGMNKEGFIEAAKSILAEYPHYQREDSWGAAMIRNAAIGDIAGMGSPAKWIAVRVNLHLNKQIELSEALQYGFDHDEEDLI
What is the function of this protein?
The presence of this protein prevents gop protein from killing E. coli.
What are the official names of this protein?
Protein beta.