Protein: S22A1_RABIT
Sequence: MPTVDDVLEQVGEFGWFQKRTFLFLCLISAILAPIYLGIVFLGFTPDHRCRSPGVDELSQRCGWSPEEELNYTVPGLGATDGAFVRQCMRYEVDWNQSSLGCVDPLASLAPNRSHLPLGPCQHGWVYDTPGSSIVTEFNLVCADAWKVDLFQSCVNLGFFLGSLGVGYIADRFGRKLCLLLTTLINAVSGVLTAVAPDYTSMLLFRLLQGLVSKGSWMSGYTLITEFVGSGYRRTVAILYQVAFSVGLVALSGVAYAIPNWRWLQLTVSLPTFLCLFYYWCVPESPRWLLSQKRNTDAVKIMDNIAQKNGKLPPADLKMLSLDEDVTEKLSPSLADLFRTPNLRKHTFILMFLWFTCSVLYQGLILHMGATGGNVYLDFFYSSLVEFPAAFVILVTIDRVGRIYPMAASNLAAGVASVILIFVPQDLHWLTIVLSCVGRMGATIVLQMICLVNAELYPTFVRNLGVMVCSALCDVGGIITPFMVFRLMEVWQPLPLIVFGVLGLLAGGMTLLLPETKGVALPETIEDAENLRRKAKPKESKIYLQVQTSELKGP
What is the function of this protein?
Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9528667, PubMed:12060594).  Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity).  Cation cellular uptake or release is driven by the electrochemical potential (i. e.  membrane potential and concentration gradient) and substrate selectivity (By similarity).  Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity).  Primarily expressed in the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds from the blood by hepatic and renal clearance (By similarity).  Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation.  Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, neurotransmitters dopamine, serotonin, noradrenaline, adrenaline and histamine, and quaternary ammonium compound such as choline.  Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover.  Involved in the hepatic and intestinal uptake of the vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism.  Contributes to the influx and efflux of fatty acid carriers carnitines and acylcarnitines across the basolateral membrane of hepatocytes, from the liver to the systemic circulation and inversely and may be involved in regulating the systemic availability of hepatic acylcarnitines (By similarity).  Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (By similarity).  May contribute to the transport of cationic compounds in testes across the blood-testis-barrier (By similarity).  Also mediates the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N-methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:12060594).
What are the official names of this protein?
Solute carrier family 22 member 1, Organic cation transporter 1, rbOCT1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein.