PharMolix/UniProtQA huggingface dataset:
Protein: FIBA_CERSI
Sequence: TETTEGDFIAEGGGVR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: HLDD_BORPE
Sequence: MIVVTGAAGFIGSNLVRGLNRRGIQDIIAVDDLTDGDKFRNLVDCSIADYLDKDEFRERVRGGNLPALRAVLHQGACSDTTERNGRYMLDNNYRVTLELFEYCQAERVPFLYASSAAVYGGSSVYVEDPANEHPLNVYGYSKLLFDQVLRTRMDSLTAQVVGLRYFNVYGPHEQHKGRMASVAFHNMNQFLAEGHVRLFAGWDGYEDGGQSRDFISVEDVVAVNLHFLDNPDQSGVFNCGTGRAQPFNDVAAAVVNTLRAERGEAALPLAELVKKGLLRYIPFPDDLKGRYQSYTQADVSRLRATGFSAPMRDVQTGVSEYVRYWRALK
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: FXL15_RAT
Sequence: MEPPMEQSGGEQEPGAVRLLDLPWEDVLLPHVLNWVPLRQLLRLQRVSRAFRALVQLHLARLRRFDAAQVGPQIPRAALVRLLRDAEGLQELALAPCHEWLLDEDLVPVLARNPQLRSVALAGCGQLSRRALGALAEGCPRLQRISLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDTAVQELARNCPQLEHLDLTGCLRVGSDGVRTLAEYCPALRSLRVRHCHHVAEPSLSRLRKRGVDIDVEPPLHQALVLLQDMAGFAPFVNLQV
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway.  Required for dorsal/ventral pattern formation.  Also mediates ubiquitination of SMURF2 and WWP2 (By similarity).  Required for bone mass maintenance.
What are the official names of this protein?
F-box/LRR-repeat protein 15.
What is the protein family that this protein belongs to?
Belongs to the FBXL15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROT_STAA8
Sequence: MHKLAHTSFGIVGMFVNTCIVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSLNAIIAV
What is the function of this protein?
Global regulator with both positive and negative effects that mediates modulation of several genes involved in virulence.  Negatively regulates the transcription of several known virulence factors such as lipase (geh), hemolysins (hla and hlb) and proteases (splA through splF, sspB and sspC).  Positively regulates the expression of sarS and other genes including those encoding cell surface adhesins (clfB, sdrC and spa).  Also, modulates the expression of genes not previously implicated in pathogenesis.
What are the official names of this protein?
HTH-type transcriptional regulator rot, Repressor of toxins.
What is the protein family that this protein belongs to?
Belongs to the rot family.
Protein: PYRG_RUEPO
Sequence: MARFIFITGGVVSSLGKGLASAALGALLQARGFSVRLRKLDPYLNVDPGTMSPFEHGEVFVTDDGAETDLDLGHYERFTGVAARKTDSVSSGRIYSNVLEKERRGDYLGKTIQVIPHVTNEIKDFISIGEDEVDFMLCEIGGTVGDIEGLPFFEAIRQFSQDKPRGQCIFMHLTLLPYIKASGELKTKPTQHSVKELRSIGLAPDILVCRSEGPIPQKEREKLALFCNVRPDSVIAAQDLSTIYDAPLAYHREGLDQAVLDAFQISPAPKPDLTKWEDVSDRVHNPEGEVKIAIVGKYVQLEDAYKSIAEALTHGGMANRVKVRIEWVDAEIFEKEDPAPHLEGFHAILVPGGFGERGTEGKIKAAQYAREHQVPYLGICLGMQMAVIEAARNVAGIAGAGSEEFDHEAGKKRFEPVVYHLKEWVQGNYKVSRKVDDDKGGTMRLGAYDAVLKEGSRVAEVYGGTAIEERHRHRYEVDIKYREQLEKAGLCFSGMSPDGRLPEIVEWTDHPWFIGVQYHPELKSKPFDPHPLFADFVRAAKESSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: FXD5B_XENLA
Sequence: MSFSQESGTHHNSLDYAGVSDEEDEIDILGEDDPCSLKSHFYLQPTHSDMGDSGMLSPSKLSCTESESDSSGESEGGTSKDSPATSPGGKAKRALVKPPYSYIALITMAILQSPHKKLTLSGICDFISSKFPYYKDKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPASEDMFDNGSFLRRRKRFKRHQQEFFKDGLMMYNSLPYYRPYSALQPQPMLQQTPLACMAIPETLSMPTNLTPYPDIKRKAHYPDQGAHRGFEGQDANNHPNKSQSKCSFSIENIMKKPKEPEPSFPSFNSHWNYNNHLLQRPSSCFLPAVLNLSTGPLLANVQGTRQYNLIKFPGSY
What is the function of this protein?
Transcriptional repressor (By similarity).  Controls the convergence and extension movements of medial neural plate precursors during gastrulation.
What are the official names of this protein?
Forkhead box protein D5-B, FoxD5-B, FoxD5b, Fork head domain protein 3, Fork head domain-related protein 12', xFD-12', Forkhead-like, xFLIP, XlFoxD5b.
What are the subcellular locations of this protein?
Nucleus.
Protein: CCD52_ORYSJ
Sequence: MSMEEAEECSAACGFSLTCQEDGADLGDGVVDDDDDGDVFLFYNAVAAADDEEEEEEYVEQMVSKEASFCCSSSSSLFDAAAGDGYGDGDGDGDWFRQARLAAVKWILETRGYFGFGHRTAYLAIAYFDRFCLRRRVDREAMPWAARLLSIACVSVAAKMEEYQSPALSEFDAGGGRVFCSDSIRRMELLVLSTLGWRMGAVTPFDFLPCFSSRLHRHHHGGAGAAGHGAAAAARVALNAVGFIFATAEAGSVLDYRPSTVAAAAILAASYGAPLTKEALESKMSNLSPSCLIDKENVHACYSMMVGDMNNNRRSSKRPLQCSDSNEITTTSTYDSVLVDDVTDTAAFAATAMNKRLRPEPPRIR
What are the official names of this protein?
Cyclin-D5-2, G1/S-specific cyclin-D5-2, CycD5;2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
Protein: Y142_METJA
Sequence: MRLKIMELRYKRELEKLIEKAEKSLEASENLYNSEFYDFAVSRIYYSMFYCVKALLLTKEINPKKHSGVLKMFAKEFIKTNELDVELFEYINEAYNYRQTADYDATIEIKKEEAEYLLHKGHIFLNKTKKYLISKNILKGENDNTKS
What is the function of this protein?
Putative toxin component of a putative type VII toxin-antitoxin (TA) system.  Its cognate antitoxin might be MJ0141.
What are the official names of this protein?
Putative toxin MJ0142, UPF0332 protein MJ0142.
What is the protein family that this protein belongs to?
Belongs to the UPF0332 family.
Protein: METK1_SOLTU
Sequence: METFLFTSESVNEGHPDKLCDQISDAVLDACLEQDPESKVACETCTKTNLVMVFGEITTKAIVDYEKIVRDTCRNIGFVSDDVGLDADNCKVLVYIEQQSPDIAQGVHGHLTKRPEEIGAGDQGHMFGYATDETPELMPLSHVLATKLGARLTEVRKNGTCPWLRPDGKTQVTVEYCNDNGAMIPIKVHTVLISTQHDETVTNDEIARDLKEHVIKPVIPEKYLDEKTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVASGLARRCIVQVSYAIGVPEPLSVFVDTYGTGKIPDKEILKIVKENFDFRPGMMSINLDLKRGGNGRFLKTAAYGHFGRDDPDFTWEVVKPLKWEKPQD
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 1, AdoMet synthase 1, Methionine adenosyltransferase 1, MAT 1.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGS_ECO7I
Sequence: MDHSLNSLNNFDFLARSFARMHAEGRPVDILAVTGNMDEEHRTWFCARYAWYCQQMMQARELELEH
What is the function of this protein?
Major determinant of cell surface composition.  Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.
What are the official names of this protein?
Surface composition regulator.
What is the protein family that this protein belongs to?
Belongs to the GlgS family.
Protein: LSPA_LEPBA
Sequence: MKLPKTPFFSVFKPGYLAFVAFGLFLDLSSKYVIITKMYAHESIPVLGDFFRLSLTFNTGFVFGLFQDNALPSLFATGFAIVFLIFYRWENSDLGNAWGWNFVMAGAFGNFLDKFFVKIPGSGFRFGFTPEKPGIEFIGVVDFLDFEWPDFLLFDRWPAFNVADSCVSIGIVILLFTMDWKEMDKK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AGUA_STRAW
Sequence: MSTPAADGFRMPAEWTPHERTWMAWPGPNPTFDHPDDLAESCRAWADVARAIRRFEPVTVVCGPGRSAEARDLLGPGIDTVERDLDDAWMRDIGPTFLTDGKGGLAAVDWTFNGWGAQSWARWEHDAKIAAYVGDLAGAKTYASKLVNEGGAIHVDGEGTVLLTETVQLGAERNPGWTREQVETEIHAHLGTSKAIWLPRGLTGDYPPHGFGTLGHVDIVAAFARPGVVVAHHQPDPAHPDHEVSKEVIGLLKAATDAHGRRIEVVEVPAPTVLEADGHWADYSYINHYLCNGGVVLCGFDDPRDETAAGIFRRLFPERTVTLVDARTIFSGGGGIHCITQQQPKN
What are the official names of this protein?
Putative agmatine deiminase, Agmatine iminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the agmatine deiminase family.
Protein: ISK1_CANLF
Sequence: NNMLQRQANCNLKVNGCNKIYNPICGSDGITYANECLLCLENKKRQTSILVEKSGPC
What is the function of this protein?
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.
What are the official names of this protein?
Serine protease inhibitor Kazal-type 1, Pancreatic secretory trypsin inhibitor.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPA2_POLNA
Sequence: MSAPADTLKSALDRTFASLRHGLETYTAQLTPHEVGTITRVSTGIAMVSGLPGVGFEELVSFSGNVFGIAFNVDETEIGVVLLGDYGHLHAGDPVRRTGRVMDVAVGEGLLGRVIDPLGRPLDSLGPVVSSARLALERPAAPIMDRAPVTVPLQTGLKVVDALIPIGRGQRELILGDRQTGKTAIAVDTILNQRGQDVLCVYCAIGQRAAAVARTIAVLREKGAMEYTVVVVTEGNDPPGLAYIAPYAATSIAEHFMEMGRDVLVVYDDLTQHARAYRELSLLLRRPPGREAFPGDIFYIHSRLLERATHLRPERGGGSLTALPIIETEAQNMSAYIPTNLISITDGQIYLSPSLFELGVLPAVDVSKSVSRVGGKAQRAAYRAVTGDLKLAYAQFEELETFARFGARLDENTQKIIEHGRRIRACLQQPESAPVSMAGQITVLLALTAAFFDGVPLARMTAAEQAVLQAAATLPAELQTRFDTAMKLSEADRATLIQLARDALKPFVPPPAESRRTSAP
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 2, ATP synthase F1 sector subunit alpha 2, F-ATPase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y5316_BACC7
Sequence: MTENNDIKMVIITGMSGAGKTVALQSFEDLGYFCVDNLPPMLLPKFIELMADSKGKMNKVALGIDLRGREFFEHLWEALDDLSERTWIIPHILFLDAKDSTLVTRYKETRRSHPLAPTGLPLKGIEAERNLLTDMKARANIVLDTSDLKPKELREKIVHLFSTETEQAFRVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIPHMKPLTGLDEEVSSYVLKFNETHKFLEKLTDLITFMLPHYKREGKSQLVIAIGCTGGQHRSVTLTEYLGKHLKPEYSVHVSHRDVEKRKGH
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein BCAH187_A5316.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: DIRA1_HUMAN
Sequence: MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRDTYIPTIEDTYRQVISCDKSVCTLQITDTTGSHQFPAMQRLSISKGHAFILVFSVTSKQSLEELGPIYKLIVQIKGSVEDIPVMLVGNKCDETQREVDTREAQAVAQEWKCAFMETSAKMNYNVKELFQELLTLETRRNMSLNIDGKRSGKQKRTDRVKGKCTLM
What is the function of this protein?
Displays low GTPase activity and exists predominantly in the GTP-bound form.
What are the official names of this protein?
GTP-binding protein Di-Ras1, Distinct subgroup of the Ras family member 1, Ras-related inhibitor of cell growth, Rig, Small GTP-binding tumor suppressor 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Di-Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: CADH_MAIZE
Sequence: MGSLASERKVVGWAARDATGHLSPYSYTLRNTGPEDVVVKVLYCGICHTDIHQAKNHLGASKYPMVPGHEVVGEVVEVGPEVAKYGVGDVVGVGVIVGCCRECSPCKANVEQYCNKKIWSYNDVYTDGRPTQGGFASTMVVDQKFVVKIPAGLAPEQAAPLLCAGVTVYSPLKHFGLTNPGLRGGILGLGGVGHMGVKVAKAMGHHVTVISSSSKKRAEAMDHLGADAYLVSSDAAAMAAAADSLDYIIDTVPVHHPLEPYLALLKLDGKLVLLGVIGEPLSFVSPMVMLGRKAITGSFIGSIDETAEVLQFCVDKGLTSQIEVVKMGYVNEALERLERNDVRYRFVVDVAGSNVEAEAAAADAASN
What is the function of this protein?
Involved in lignin biosynthesis.  May catalyze the final step specific for the production of lignin monomers, like coniferyl alcohol, sinapyl alcohol and 4-coumaryl alcohol.
What are the official names of this protein?
Probable cinnamyl alcohol dehydrogenase, CAD, Brown-midrib 1 protein.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: DER_LISMF
Sequence: MAKPVVAIVGRPNVGKSTIFNRIVGERVSIVEDVPGVTRDRIYNSAEWLGKEFNIIDTGGIDLSDEPFLEQIRAQAEIAIDEADVIIFITNGREGVTDADEQVAKILYRSNKPIVLAINKVDNPEMRDQIYDFYSLGFGEPYPISGSHGLGLGDMLDAVRAHFPKEEEEEYPDDTVKFSLIGRPNVGKSSILNALLGEDRVIVSDIAGTTRDAIDTTYTFDGQDYVMIDTAGMRKRGKVYESTEKYSVLRAMRAIERSDVVLVVINAEEGIREQDKRIAGYAHDAGRAIIIVVNKWDAINKDEKTINVWTEDIREQFQFLSYAPIVFVSAKTKQRLNNLFPLINQVSDNHSLRVQSSMLNDVISDAVAMNPSPMDKGKRLKIFYTTQVAVKPPTFVVFVNDPELMHFSYERFLENRIREAFPFEGTPIRVIARKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: Y291_MYCPN
Sequence: MRFFNKYKLFLDCAYKHLNIVLLDFKTNTVVDQLTIPVQQNLTELAVYHLEKLLKKNKVRNNTVRQFYVTTGPGSFTGQRVGAIIAKTWCTVNPNCQLFALNSLRLQIPYGCGISKISAGNEKNYCGLFTETTSEIALLAKPDFVKLCKANTELPVYENFENIDSIEELFLNNIERFELVENPQNLELLYLKDPVN
What are the official names of this protein?
Uncharacterized protein MG208 homolog.
Protein: Y3500_VIBCM
Sequence: MNSVFEIVSLARRKNKLQRELDDNEKKVRDNRKRVELLVNLLDYIKPNMSHEEILGIIKNMKSDYEDRVDDHIIKSAEISKERRDISRRIKDLTEHDKQMTQGKKA
What are the official names of this protein?
UPF0265 protein VCM66_A0700.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: RL18_BUCA5
Sequence: MIFSNKNKIISRIRRSMKTRCKIKKLGAIRLVVHRTSRHMYAQIISSKEAKVLVFASTLERKINCSLKYTGNKEAAAKIGKIIAERALSKGISHVSFDRSGFKYHGRVQVLAESAREVGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: LPTD_FRATT
Sequence: MLKGIHKYLLMCFGTVLFTVQANAARIMSNNPIKEDWQCKVVDGEWSCKRAKKPKSVFDKKLTKTEKEKALADDLAWVKKPSYFVGGYYSNDNQFTKALCESKKTDLSYEKSEFDNYGTLIASGNVQVLQCDQELYGNNAIINLNSNNSAIRSLVMAGDVIVKQPSTGIVIRTTELDADMNNGTYSTGEAYFRLAREMPKTRIYDKEHFSGYLRGYAKTFKKESSGDIVLSDGYITSGDPYDNAWKITGNNIDIDTNTHMAYVKNGYFEIQDIPVMYIPYFSHPIDDRRRSGFLYPGFVQNANSGIGISVPYYFNLAPNYDLMLQSVIWSQRGIIENGTFRYMTKYFQGQFEGSLVPYDFKEGKMRGSFTLSTTGQYENINTNFKYEYVSDQNYYNDFSAGNVNLVTKTLLDREFDLTYTNDYVDSGLTVLDYGVVNPLLTVDNTPYAKLPEVKLNLTSDGYTPDYLTLSAQTLNTFFYKTAGPANTNPGAPQGTNVNAFRAYESPKIAFNFNKTWGYLNPSLEVPIRYYQLKNSPTDTIQFANSSVTSVLPIFNIDAGAYFDKDYTNENGTYTSTLHPRLFYTYIPYQDQTNIPLFDTSLQNEQYMQMFQVNRFTGYDRINNANQLTYAIEASTTNQDNGTTLASAKIGQMAYFADRKVNLCQGNSACPNPGLMDPFSTDTFSPIMSSFEFQVMKNIYLSAQVNYRVNQQNVDYQVYQLSYKDENENIFNVSYNNIANNWNSLTQQQIAEGAKPQPQETITLSTVLNITDHWGIAALWNYNFQQKQIANIFAGLQYNAKSWAVRALWQKTAYTNQDPNNPTLLGPLVNTYMFEFELKGLGGIGNTSDISSRLQQINGYQVGEWGNGI
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: DPO3A_THEMA
Sequence: MIPWVISPYSFDGSVVRFEKLALLLKRKGLKSVILADRNFHAAVKFNTIMRKHGLIPVHGLWKDGRIFVARNREEFDSLVRYYNGETHEIEDIPVFQESELTPVRYLDASEKKASIFMRKIFGLDEDVQGFPEKCEDVADILNAEAYDLRVNHRFPTPPKNWNELLIKKAEPLGEEYISRLKRELEVIKRKGFTPYIYTVEKVVEIAKKMGIKVGPGRGSAVGSLVAYLCGITEVDPIKYDLLFERFLNEERQEPPDIDVDVEDRRRKDLIKELSKSFQVYQVSTFGNLTEKSLKNLINSVLPDASLEEKNEIYKTVYGLPHHPSVHAAGVVISENPLPLPTRTEEDIPITDYDMYDLQEIGVVKIDILGLKTLSFIKDFKKEIFDYSDEKTYHLISKGKTLGVFQLEGLQARKLCRRISPRNMDELSILLALNRPGPLRSGLDVMFSNSKNVPAFFRKMFPETRGVLIYQEQIMRLAMFAGLSGTEADILRRAIAKKEREKMEPLLEKMKKGLLEKGMENAEQILEILLNFSSYAFNKSHSVAYAHITYQTAYLKAHHLEEFFKLYFAYNSSDAGKIFLAVQELRNEGYRVHPPDINISGKDLVFHGKDVYLPLTVVKGVGVTLVEQIEKIRPVSSVRELQERVTGVPRNVVESLITAGAFDKLYENRKLALEELNKRVEKDILEIRSLFGEKVEQESSNIKIGDITELEEKSMGFPLTPVHEVPTGLFARIDDVFTYGRILPVLVKRVSRNIVTDGLSVCRVRTDVPDGVHLVLLSPLQKIIKIWPFNENTRFVYRVDFTATLEKAGQNEITEVLKNGAVVRYEGYRPLTDEYRYRVVPR
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_STRS2
Sequence: MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYATGEWLNRKFSLIDTGGIDDVDAPFMEQIKHQAEIAMDEADVIVFVVSGKEGVTDADEYVSRILYKTNKPVILVVNKVDNPEMRNDIYDFYSLGLGDPYPVSSVHGIGTGDVLDAIIENLPAQEAEENPDIIKFSLIGRPNVGKSSLINAILGEERVIASPVAGTTRDAIDTHFTDPEGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIERSDVILMVINAEEGIREYDKRIAGFAHEAGKGMIIVVNKWDTLEKDNHTMKQWEDDIRDQFQYLSYAPIIFVSALTKQRLHKLPEMIKAISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKPPTFVVFVNEEELMHFSYMRFLENQIRKAFVFEGTPIHLIARKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: OLD_THESS
Sequence: MLKRLQVKNFRCLEDIDLPLGPLTAIVGPNGAGKTTILRAIDLVLGDVWPSLRSFRIPQDFINFDTTRAIEITVHFDPPYTQGSFNITAFRLTCKGEDADFHVDLEPLDEGGNVPRYPSGNPLRVGTDMRNHARVLFLDHRRNLAQHLPSIRGSILGRLLQPVRREFKLQDNFKQVYEQAMDLLRTEQVKQIEKTIAETAKQMLGFLGKDAMKSMEIGFGFADPANPFNSLRLQYRESDLTLPGDELGLGIQSAIVVGIFEAFRQLGEKIGTVIIEEPEMYLHPQAQRYFYRLLCEMADKDQCQIIYSTHSPIFADVNRFEALRLVRKDRDDRVVVSYVREEDKSALDNVRNRFKLGGRFDTARNEVLFAKRALLVEGYGDRVAALQLFNQLEVDPDAECIAVVDCGGKAGIELIVGVCKALDIPFVVVHDEDVWPIDERADEETRRKQEQENKAEQEKNQRIQACAGAERVFVVQPSLEAALGIGRNASDKPYRIAEILKTVDVGQPPDALRPFVEAIRQVTRPMEE
What is the function of this protein?
An exodeoxyribonuclease that degrades linear or supercoiled dsDNA from 5'-3'.  Nicks and linearizes circular DNA.  Activity is not stimulated by ATP or AMP-PNP, although it has DNA-stimulated ATPase activity.
What are the official names of this protein?
OLD nuclease, Exodeoxyribonuclease OLD, Overcoming lysogenization defect, Old.
What is the protein family that this protein belongs to?
Belongs to the class 1 OLD nuclease family.
Protein: Y1276_SULIL
Sequence: MVKVMVVAEVRPSEDVNKVLSAISNFFDFEKTNTRKEGIIDILVLEARTLKSLLKFHRVLRNERILDSARKYLMKGIEGNTIAFMIHKQAAAVGVLSFVDSDKESPLGAIKFYIEYQNPKEVVDWLAPRTAHGVPLWDNPIPPDV
What are the official names of this protein?
UPF0201 protein LS215_1276.
What is the protein family that this protein belongs to?
Belongs to the UPF0201 family.
Protein: RL22_RICCN
Sequence: MVQENKNFATAQAKSIRVSSRKLNLVAAFIRNMKVSEALVQLTFSPKRIAKVVKDCLQSAVANAENNLGLDIDRLVVTKATVGKALVMKRVMPRAKGRATRINKFFSNLYITVTEKEDN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: ACM1_MACMU
Sequence: MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRPPRLLQAYSWKEDEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
What is the function of this protein?
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.  Primary transducing effect is Pi turnover.
What are the official names of this protein?
Muscarinic acetylcholine receptor M1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: IL5_CERAT
Sequence: MRMLLHLSLLALGASYMYAIPTEIPTSALVKETLTLLSTHRTLLIGNETLRIPVPVHKHHQLCTEEIFQGIGTLESQTLQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES
What is the function of this protein?
Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils.  Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity).  Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB.  Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).
What are the official names of this protein?
Interleukin-5, IL-5, Eosinophil differentiation factor, T-cell replacing factor, TRF.
What is the protein family that this protein belongs to?
Belongs to the IL-5 family.
What are the subcellular locations of this protein?
Secreted.
Protein: METK_METTM
Sequence: MRNIIVEPLNQTPIEDQKVEIVERKGIGHPDSISDGIAESVSRALCNAYLDRFGAIMHHNTDEVQITAGESAPQFGGGEVIKPIEILLTGRGIAEVDGEKIGLDRIAISAAKEYLRDNIINLDVETCTVVECKIGHGSGDLRDVFARKGRAPLSNDTSFGVGFAPFSETERIVMEAENLLNSPEFKKKYPAVGEDIKVMGLRENDNITLTVACAMVDRYVSDLEEYLEIKNVVKDEVFKLASGITERNLEVFVNTADRCEDDEPSVYITVTGTSAEMGDDGSVGRGNRANGLITPNRPMSMEATSGKNPINHVGKIYNLLSNQMAADIVESIEGVKQVHIMILSQIGKPIDHPKAATAQVILEDGYTMDDITGKVSGVMDAWLEDIPSITEMLVKGQLRTF
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase 2 family.