PharMolix/UniProtQA huggingface dataset:
Protein: PURA_PROM2
Sequence: MANVVVIGAQWGDEGKGKITDLLSRSADVVVRYQGGVNAGHTIVVDDKVLKLHLIPSGILYKNTSCLIGSGTVVDPKILLKEIDMLIDNGIDISGLKISSTSHVTMPYHRILDEAMEADRGSNKIGTTGRGIGPTYADKSQRNGIRIRDLLNNERLKDVIEIPLREKNGLLEKIYGIKPLKLEDILEEYLDYGERLSKHVVDCTRTIHAASKNKKNILFEGAQGTLLDLDHGTYPFVTSSNPISGGACIGAGVGPTLIDRVIGVAKAYTTRVGEGPFPTELQGSINDQLCDRGSEFGTTTGRRRRCGWFDGVIGKYAVSVNGLDCLAVTKLDVLDELDEIQVCIAYDLDGEEIDYFPTNSDDLKKCKPIFKKLKGWQCSTADCRKLSDLPQNAMNYLRFLAELMEVPIAIVSLGANRDQTIVIEDPIHGPKRALLR
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNX4_CRYNB
Sequence: MDQDGFHSIAWDDAPSSNPPLSAPSPSQSPFEEGFESISPSSAQPPASDQYEGYDNSKAGEAGDVGVTLDRRERLGGHEVDGSVWNGKWMDVQVREPAKEHEGSKDMYVSYAVKTETSLPTFRKPLTVVRRRFQDFVFLREHLVKNFPACVVPPIPDKHRLEYIKGDRFSPEFVERRRLDLQRFADRIARHPVLQRSQLVNDFLQSTEWSVAKHHHISHPPPESHASLIDSLSDTFINAFSRVRKPDARFVEMTEELERFEEGLTGVERVVGRGKSRVDDLAADYQDMAAAYQGLGYLESGITEPLNRFAEKMLDFSTLLKHMNNTTIEPFLSSSHSLLSYSATHRNVIKLRDQKQLDFEELSAYLSAIVSERDRLAALSSGHTAAPVGLGTYLRDQMDKLRGTDDIHTRRERMRKMDGKIKELQDAVTLAHETSNAFSEEVIKEHAYFELEKKQEMKDALQAYTDGQVEMLQQAMDDWDRIIPLLQRIRVDV
What is the function of this protein?
Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells.  Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), autophagy, mitophagy, and pexophagy.
What are the official names of this protein?
Sorting nexin-4, Autophagy-related protein 24.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Preautophagosomal structure membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures. Associates to phosphatidylinositol 3-phosphate, necessary for peripheral membrane localization to the perivacuolar punctate structures.
Protein: O1612_CONPE
Sequence: MKLTCMMIVAVLFLTAWTVVTAVPHSNKRLANLYLKARHEMKNPEASNVDKRCFESWVACESPKRCCSHVCLFVCA
What are the official names of this protein?
Conotoxin PnMKLT1-1111.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL27_FRAAA
Sequence: MAHKKGASSSRNGRDSNAQRLGVKRFGGQFVKAGEIIVRQRGTHFHPGELVGRGKDDTLFALSAGHVQFGHRRGRRVVNVVEQVAAPAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RL13_SALAI
Sequence: MRTYSPKPGEIERQWHVIDASDVVLGRLATHAATLLRGKHKPTFAPHVDTGDFVVIVNAGKVALTGNKRQQKIAYRHSGYPGGLKQLGYDELLTKRPERAIELAVKGMLPHNKLGRKLIKKLKVYAGAEHPHGAQQPVPFEIKQIAQ
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: HEXB_PIG
Sequence: MEVLPGLLRLLAALVVAERWARDTSGAESLGLWPLPFAVDISPRSLHLSPNNFFFGHSPTSKAGSSCEILQEAFRRYYDFIFGFYKWHQGSYQLCFGTELQQLQVHVESECDTFPSISSNESYVLHVKGPEALLRANTVWGALRGLETFSQLIYQDSYGTFTVNESEIIDFPRFPHRGILIDTGRHFLSVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSINFGVLSSKGSYSLSHVYTPNDVRMVIEYARIRGIRVMPEFDTPGHSRSWGKGQKDLLTPCYRKQVLSGTFGPINPILNTTYNFLSKFFKEISTVFPDEFIHIGGDEVDFDCWASNSEILQFMQEKGFSQISLNSNLCTVFKISNMISAMKKRPIVWQEAFDGRDKFMPGTVVQVWKIEDYKWEQSLITKAGFPVILSAPWYLDLISYGQDWKNYYEVEPQDFPGSDKERKRVLGGEACLWGEYVDATNLTPRLWPRASAVGERLWSHKDVRDIHDAYSRLTIHRCRMVRRGIAAEPLFTGYCNHEHRM
What is the function of this protein?
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides.  The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide.  Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity).  During fertilization is responsible, at least in part, for the zona block to polyspermy.  Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity).
What are the official names of this protein?
Beta-hexosaminidase subunit beta, 65 kDa epididymal boar protein, Beta-N-acetylhexosaminidase subunit beta, Hexosaminidase subunit B, N-acetyl-beta-glucosaminidase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 20 family.
What are the subcellular locations of this protein?
Lysosome. Cytoplasmic vesicle, secretory vesicle, Cortical granule.
Protein: PPNP_CUPTR
Sequence: MEVSQFDNVSVVKKANLYFDGKCVSHTVLFPDGTRKTLGVIFPASLTFNTGAAEIMEINAGTCRVRLAGSEDWQAYGAGQQFSVPGNSSFDIEVQETLDYVCHFE
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: OCA4_YEAST
Sequence: MLVPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVPVKSSSVSNANLYSNNNSTLSLQEEKKKSTANGSQNSTTGDPVIQEELAYHLTDNDDLMLIKSTCLKRTFKTLLNVDNYNVLLVDKTALVIGILRKIQKWNIASIINEYRLFSGKNRNYFAETFLEIINIEIEQEKDNKTIVDNKAKKLPLENNRTHSIEYKANSGKLIRVNEDDLCREPEVPQRLLTLINQIETKVKNNKVLQVSGVLGDDLKKTSSDLGIFGHRYRLAFNKKENGDYGYYKARGKDNVKIRIPCDSELPDWFRFQRDLWEKENVPEEHHFYREHIFT
What is the function of this protein?
Required for replication of Brome mosaic virus (BMV).
What are the official names of this protein?
Protein OCA4, Oxidant-induced cell-cycle arrest protein 4.
Protein: PTTG_PONAB
Sequence: MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN
What is the function of this protein?
May facilitate PTTG1 nuclear translocation.
What are the official names of this protein?
Pituitary tumor-transforming gene 1 protein-interacting protein, Pituitary tumor-transforming gene protein-binding factor, PBF, PTTG-binding factor.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=May be cytoplasmic and nuclear.
Protein: Y4114_PSEU2
Sequence: MQRSTRQQAGREAEAFALQFLQRQGLRLIEQNWLCKRGELDLVMLDGDTVVFVEVRYRRHSGWGGAMESVDFRKQEKLVTAAQLFLQHATAWANHPCRFDVIAIEGEPGNAAPLNWIKSAFDS
What are the official names of this protein?
UPF0102 protein Psyr_4114.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: MAP10_RAT
Sequence: MAATAAERLFSLELLVDWVRLDSPCFASPAVAFRLLDFPPLLILPPAAPDPEPQRGAITFGRGKACLLRLRPAALRRPRLRAALLQLPAVPTPAPLLLGACDILLVPSVGQRGIFTLRGPEAERVGELALFYRLTDLGRFPPGAPQLRSPLSPACITGSEALEVSEPRTKETSKPCTKDTSARCLQCVSNGRFLEAPEPCAKDTDNWSAGDSDASAVQKSWEEAILHSKASSGDMASAPCSPAPSGRTVSPVSLEVTELDFETNTFCPPPLYYTHLTQEKAPSARVEITIEPQRNEPEDLEDAFPETKPVGPTIRPVKHTRAAIQESPPVLLNLPQMQGPGEANEAPCPPQTEQSTVGAIRQLPLLNALLMELSLLCNQPVANPSQVHPHLAWLYRGEHKGPDPSTKSTSRSESKSNKLSAQENEKLVSPQSTKNPKGKHSKISGSPPPKVTKGRLLYGLTNTLRLRLQQTNPGMLVVHEKREQYRRSQIRAVGPKFRIPSWKGKVSSLAAESQMPPQLPGDTLTDSNGKVSSWAVQSQLPPQLPRDRSLDSYGSFAEGSDTSMLISSGFDESSRTREAKQSHAMKKETVGQSENKTVTSLRAPVSPAVSVIPERSPRSNILRGKWKKQVQSPGLSRQDPAVDKAVGEGIDGKQVKAASAADTNENRPPSRKSSCESTSELQCWDGSTSPCYSEDFCTTENNSRSLPAPDSSTGAEYAQKGSWASKSSEARLSTRKNSSESSSVFTPPFSAGSPVCSQKRSRVLKTHDSLEEASSLSTSDFSSQWTNEKENQADPGSSKIRRRQDRSTKLKVGTGHKSSEKSHSARTSQVSSYEPSNLSELELKAIDDIDSASTGFQEEEDGLGSLRISRQCRDICELVINKLPGYTV
What is the function of this protein?
Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.
What are the official names of this protein?
Microtubule-associated protein 10, Microtubule regulator of 120 KDa.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localized at stabilized microtubules (MTs) during interphase and to the mitotic apparatus during mitosis. Localized at spindle poles in metaphase and spindle midzone during telophase. Colocalized with Polo-like kinase PLK1 to the center of spindle midzone. Localized at the midbody during cytokinesis. Colocalized with acetylated-tubulin at MTs (By similarity).
Protein: YBEY_SHEPC
Sequence: MSLELALDVQYATTSDWLPTEEQLMLWAKTAIGNGMDRAELTIRIVDSRESQMLNSTYRGKDKPTNVLSFPFEAPAEIELPLLGDLVICAAVVENEAREQNKTLEAHWAHMVVHGCLHLLGYDHIEDEEAEEMESLETQLIESLGFTNPYKEQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_AZOVD
Sequence: MLQPKRTKFRKQMTGHNRGLAHRGSKVSFGEFALKSVSRGRLTARQIEAARRALTRHVKRGGKIWIRVFPDKPVTKKPLEVRMGKGKGNVEYWVAQIQPGKVLYEIEGVSEELAREAFALAAAKLPLATTFVKRTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RR4_DIOEL
Sequence: MSRYRGPRFKKIRRLGALPGLTSKRPRSGSDFKNQSRFGKKSQYRIRLEEKQKLRFHYGLTEQQLLRYVHIAGKAKGSTDQVLLQLLEMRLDNILFRLGMASTIPAARQLVNHRHILVNGRIVDIPSYRCKPRDIITSKDKQRSKVLIQNSIESSPHEELPKHLTIDSFQYKGLVNQIIDSKLIGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: VIF_HV1Z2
Sequence: MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSKKASRWFYRHHYDSPHPKISSEVHIPLGEAMLVVKTYWGLHTGERDWHLGQGVSIEWRKRRYSTQVDPGLADQLIHMYYFDCFSEAAIRKAILGHIVSHRCEYQAGHSKVGSLQYLALTALVAPKKIKPPLPSVRKLTEDRWNKPQKTKGHKGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: ENO_THEPX
Sequence: MSSIIDIFAREILDSRGNPTVEVEVELDSGAVGRAAVPSGASTGAFEAVELRDGDKSRYLGKGVLKAVQNVNDIIAPELIGMEAQDQVAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAAEECGLPLYQYIGGVNAKTLPVPMMNILNGGKHADNNVDIQEFMIMPVGAPNFREALRMCSEVYHNLKNVLHSKGLSTTVGDEGGFAPNLTSNEEAIQVILEAIEKAGYVPGEDIVLALDPAATEMYKEDGKYHFEGEGIVRTSAEMVDFWEQLVNKYPIVSIEDGLAEEDWNGWKLLTERLGKKIQLVGDDLFVTNTQRLSKGISMGVANSILIKLNQIGTLTETLDAIEMAKRAGYTAVVSHRSGETEDSTIADLVVGVNAGQIKTGAPARTDRVAKYNQLLRIEEVLGSTAQYLGKNAFYNIKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RS14Z_BEUC1
Sequence: MAKTALIQKANSKPKFGVRAYTRCNRCGRPRSVYRKFGLCRICLREMALAGQLPGVTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: DEOB_CLOB8
Sequence: MKKYNRIFTIVIDSLGIGEMSDSKEYGDVNVDTLRHISESVDEFKIPNLQKLGLANLHPIKHVEAVEKPLAHFMKMREASVGKDTMTGHWEMMGLKIETPFQTFTDTGFPQELLDELEKRTGHKIVGNKSASGTEILDELGEHQIKTGDMIVYTSADSVLQICGHEETFGLDELYRCCEIARELTLKDEWKVGRVIARPYLGMKKGEFKRTSNRHDYALKPYGATALNALKDNGFASISVGKINDIFDGEGITESNKSKSSVHGMEQTLEIMDKEFKGSCFVNLVDFDALWGHRRNPVGYAEELEKFDVNLGKVLDKLKEDDLLIITADHGNDPTYKGTDHTREHVPFLAYSPSMTESGLMETSDSFAAIGATIAENFGVKMPENTIGESVLSKLV
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_BRUA1
Sequence: MEHPVFERDPSEKSETERREVPPLLKLALELGPLLVFFFANARGEMLIERFPILGSIGAPIFLATALFMAATVIALAISWSMTRTLPIMPLVSGIVVLVFGALTLWLHNDTFIKMKPTIVNTLFGGILLGGLFFGKSLLGYVFDSAFRLDAEGWRKLTLRWGLFFIFLAIVNEIVWRNFSTDTWVSFKVWGIMPITIVFTLLQMPLIQKHSLTDEENTAS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RF1_CHLTE
Sequence: MFDKLQSIKDKFQTIEQQLSDPEVVADQNRFRKLNKEYSSLKEIVRAYDEWSRTKKQLDEAHSMQKNENDPEMRALVEEEAGELQERLPKLEQQLKILLLPKDEADSRNAIIEIRAGTGGDEAGLFAADLMRMYQRYAERQGWSCQTLEVSEGSVPGSLKEVSLEVSGHNVYGILKFESGVHRVQRVPETETQGRIHTSAASVAVLPEAEEVDVEIRKEDLLIDTFRSGGKGGQNVNKVETAVRITHVPSGIVVACQEERSQLQNRERAMKMLRSKLYDLQIAEQQKSRADLRRSMVTTGDRSAKIRTYNFPQSRVTDHRIGFTSHALPQIMQGELDPLIEALRMHDQAERLQAETA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUG_PECCP
Sequence: MITDILAMNLQVVFCGINPGLSTAHHGYHFANPSNRFWKVIHHVGFTERLLTPAEEQHLLDTGCGITMLVERPTVEATELGRDELLQGGNAIVEKMERYQPRALAVLGKQAFSQAFGIKKVSWGRQSLNIGETQVWVLPNPSGLNRATLESLVASYQELHQALQDKA
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_SACD2
Sequence: MRASKYLIATYKETPADAEVISHQLMLRAGLIRKLASGLYNWLPAGLRVLRKVETIVREEMDRAGAQEVLMPVVQPAELWEESGRWQQYGPELLRINDRHDRAFCLGPTHEEVITDLIRNELKSYKQLPANFYQIQTKFRDEVRPRFGVMRAREFLMKDAYSFHASQECLQETYDIMHAAYCKIFDRIGLDYRPVLADTGSIGGTGSHEFHVLADSGEDDIAFSTESNFAANVELAEALAPAKQTAEPLPREEVATPNVKTIEDVAKLLDVPTTQTVKTLIVKGVENEDGKHTLVALVLRGDHALNDIKAIKLAHVANPLEFADESGIKAAVGAEVGSLGPIGLSMPVYVDRAAAALVNFVCGANKDGYHYTNANWSDAAEHKVVDIRNVVIGDPSPCGKGTIDIKRGIEVGHIFQLGTKYSEAMKASVLDENGKDKTMIMGCYGIGVSRIVASAIEQNYDDNGIIWPDAIAPFHVAIVPINMQKSEAVAQKCEELYAQLNQLGYDVLLMDEPKARLGGMLADTELMGIPHRIVVGDRGLEKGQLEYKCRRDSDSQDIAVDDIIEFINNAVKTGK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_CLAMS
Sequence: MGILETITGPRDLDRLSREQMVELAAEIRQFLVAEVSKTGGHLGPNLGVVETTLAIHRVFDSPRDAIVFDTGHQSYVHKLVTGRQDFSRLREAGGLAGYPQRSESEHDIVESSHASSSLSWADGISRAFGITGQTDRHVVAVVGDGALTGGMTWEALNNISDDNTRKLIIVVNDNGRSYAPTIGGMARFLNTVRTRRTYRGLYETSQRVFGVFGAPGDSLYRGLRGGLHGFLTRVTDNEALYSNLDIKYLGPIDGHDQQAMEEALEQARDYGAPVIVHAITEKGRGYEPARRDVADQFHAVGQIDPETGEPIDPSHAVSWTSVFADEILALADEDPRIVGITAAMLRPVGLHKFAEKHPDRVHDVGIAEQHAVTSAAGLAYGGLHPVVALYATFVNRAFDQVLMDVALHRAGVTFVLDRAGVTGPDGPSHHGMWDLALLQIVPHIRLSAPRDATRLREELGEAVKVDDAPTVVRFSKGSVGDEIEAVRRLDDGVDVLHESASKDVLIVTVGPMATMGIEVAERLAAQGIGATVVDPRWVVPVPRSVVELGGTHRLVVTIEDGVVVGGIGTRIRQDLREAGIDTGVTELGLPDEFLDHGTRSQILERVGLTPQHIARDVVAQVLGSRVPSARPLPEDAERVPMRAEDDEQA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: SPOK3_PODAS
Sequence: MSDKDRITQLLRELEEAKAREAQERCEKERLQLEHRKTTFLEYLRNCHRHLYNALRLTDTSRSSTGYTKVVGKYYPKRLRPWTNFTNVLHPHYFNLVQQICGQRQLFESASTTKNLGTIISDHLAGNEKAIDRFEVDAVERPVQGILKVLATHEEAGKASICPEFRFSANLRELTQKDDGSSGADDNTSDRSLERRQQAGPNKRPTSKSKYICSNRQPDGVGIRMQPDGGQTQAFIYDYKAAHKVAIEHVRSATAKEHLFHEVVARINDDKLSRDEEVQHREQAEAFIAMALTQVFDYMITYGVSYGYVAAGRCLLLLYVDRDDWQTLYCHPCLPADDVGEPTNDWTDRLSHTAVAQLVSFCLSSFQSEALEGQSLETALSVAKATLKTWSESYADVAYLGLEPAELSSAPSSQNTDISEYTSKAKPTGRKVTLRSCKPAAVLPQGNEHDEHDEEDHSEPGASRLAKRERGPSSGGKDDGRSMVDPQPTRQYCTQACLLGLKRGKDLDENCPNVSLHRFDGSSRHPVNAHSFTDMVEQQLLLSPYKGCRMVDFWGKRGAMGWLFKLELLPYGYTFVGKGTVEDRLNRLEHEGRVYARLDHLQGDVVPVHLGLVRLDRGYILPGLEFAVYMMLMSWAGQTPSANMDDAETLKSESLTAIWSEGVDHGDNNRANYLWNAERCRIMIIDFDRAHLFPPLKARAVSRLSKPKRKRETLNSYLTEITGREARHVFKQMDRSPMATPSHGG
What is the function of this protein?
Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system, leading to poisoning of progeny that do not inherit the allele (PubMed:31347500).  May possess DNA nuclease activity that leads to spore killing, and a kinase activity that confers resistance to the nuclease activity (By similarity).
What are the official names of this protein?
Meiotic driver SPOK3, Spore killer 3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL13_MESH7
Sequence: MRQTTFVKHQEVKQKWFVIDAESKILGRLAAFVASRLRGKHYPHFTPNVDMGDKIIIINAEKILLTAKKEEQKLYYNHSGYPGGLRVRTAREMRAKKPIALLERAIYGMIPHTKLGDKQRKNLYVYSGSEHPHLGQNPEKLEVK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: CARE_STRTH
Sequence: MPLPKHLPALGGMRFISALLVFTSHISTQPFFKNTEINSALQFPLNRLGPLTVSFFFMLSGFVLTWAGLPDKSKVNFWRRRTVRAYSLHLPVLLVTLLIVLALNEPNMGRSVWDGLLTNLLLIQAWFPDHHEYGSMNPVAWSLSCELFFYAMFPFLFAFFTKVRTDRLWRWAAAVSVAAVSIPLVALLLPASPPLPWDPDMPQLRWWFIYMFPPVRLLEFVLGMLMAQIVIRGRWRGPRPLACVALFSAVFAVTFAVPNHYDPGALTVPVIALLLASVAVGDVRGVRSWLGTRTMVLLGELTFAFYLVHYLIIQYGHRFAGGKQGYYRQWDTPAAVGLTLLAFTLALGLSAFLHFFVEKPVMRTLGRPRRSPDAGSTPRSEPAPSGTP
What is the function of this protein?
Catalyzes the acylation of the mycaminose sugar during carbomycin biosynthesis.  Recombinant strains containing care can use spiramycin as a substrate and convert it to the hybrid antibiotic, isovaleryl spiramycin.
What are the official names of this protein?
4''-mycarosyl isovaleryl-CoA transferase.
Protein: MEP50_RAT
Sequence: MRKESPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGSLLLGASSLSGRCWAGSLWFFKDPSAAPNEGFCSAGVQTEAGVADLTWVGDKGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVTVLSSGTQAVSGSKDFCIKIWDLAQQMSLNSYRAHAGQVTCVAASPHRETVFLSCSEDSRILLWDTRCPKPASQMGCNASGYLPTSLAWHPQQSEIFVFGDENGSVSLVDTKNASCTLSSAVHSQCVTRLVFSPHSVPFLASLSEDCSLAVLDSSFSEVFRSRAHRDFVRDATWSPLNHSLLTTVGWDHQVIHHVVPLEPLPAPGPDSVVE
What is the function of this protein?
Substrate-recognition component of the DCX(WDR77) complex, which mediates ubiquitination and degradation of Irgm in intestinal cells.
What are the official names of this protein?
Methylosome protein 50, MEP-50, WD repeat-containing protein 77.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.