PharMolix/UniProtQA huggingface dataset:
Protein: GSTU7_ARATH
Sequence: MAERSNSEEVKLLGMWASPFSRRIEIALTLKGVSYEFLEQDITNKSSLLLQLNPVHKMIPVLVHNGKPISESLVILEYIDETWRDNPILPQDPYERTMARFWSKFVDEQIYVTAMKVVGKTGKERDAVVEATRDLLMFLEKELVGKDFLGGKSLGFVDIVATLVAFWLMRTEEIVGVKVVPVEKFPEIHRWVKNLLGNDVIKKCIPPEDEHLKYIRARMEKLNIKSA
What is the function of this protein?
May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
What are the official names of this protein?
Glutathione S-transferase U7, AtGSTU7, GST class-tau member 7, Glutathione S-transferase 25.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Tau family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HLGA_STAAR
Sequence: MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHEKGKGDKSEFEITYGRNMDTTYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
What is the function of this protein?
Toxin that seems to act by forming pores in the membrane of the cell.  Has a hemolytic and a leucotoxic activity (By similarity).
What are the official names of this protein?
Gamma-hemolysin component A, H-gamma-2, H-gamma-II.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSTS2_STRA5
Sequence: MKKHKMLSLLAVSGLMGIGILAGCSNDSSSSSKGTINIVSREEGSGTRGAFIELFGIESKNKKGEKVDHTSDAATVTNSTSVMLTTVSKDPSAIGYSSLGSLNSSVKVLKIDGKNATVKDIKSGSYKISRPFNIVTKEGKEKEATKDFIDYILSKDGQAVVEKNGYIPLDNAKAYQAKVSSGKVVIAGSSSVTPVMEKIKEAYHKVNAKVDVEIQQSDSSTGITSAIDGSADIGMASRELDKTESSKGVKATVIATDGIAVVVNKKNKVNDLSTKQVKDIFTGKTTSWSDLSK
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.
What are the official names of this protein?
Phosphate-binding protein PstS 2, PBP 2.
What is the protein family that this protein belongs to?
Belongs to the PstS family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: COAD_GLOC7
Sequence: MIAIYPGSFDPITLGHLDIIERGGQLFDLVIVTVLRNPNKQPLFSVEKRVEQIRECTQHLSNVEVDSFTGLTVEYAKLRNAKVLLRGLRVLSDFEKELQMAHTNVTLWDGIETVFLATAKEYSFLSSSIVKEIAKFGGSISHLVPKNVAQDITLYYS
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSTF2_MOUSE
Sequence: MAGLPVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGESISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLISGNPQPVHVAGPGSGPNVSMNQQNPQAPQAQSLGGMHVNGAPPMMQASMPGGVPAPVQMAAAVGGPGPGSLAPAGVMQAQVGMQGAGPVPMERGQVPMQDPRAAMQRGALPTNVPTPRGLLGDAPNDPRGGTLMTVTGDVEPRAYLGPPPPPHQGPPMHHVPGHEGRGPPPHDMRGGPLAEPRPLMAEPRGPMLDQRGPPLDARGGRDPRGLDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEARAMEARGMDTRGPVPGPRGPMPSGIQGPNPMNMGAVVPQGSRQVPVMQGAGMQGASMQGGSQPGGFSPGQSQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
What is the function of this protein?
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.  This subunit is directly involved in the binding to pre-mRNAs (By similarity).
What are the official names of this protein?
Cleavage stimulation factor subunit 2, CF-1 64 kDa subunit, Cleavage stimulation factor 64 kDa subunit, CSTF 64 kDa subunit, CstF-64.
What are the subcellular locations of this protein?
Nucleus. Note=Localized with DDX1 in cleavage bodies.
Protein: HIS5_SALPA
Sequence: MNVVILDTGCANLSSVKSAVARHGYTPVVSREAEIVLRADKLFLPGVGTAQAAMDQLRERELIDLIKACTQPVLGICLGMQLLGRRSEETRGVDLLNIIEQDVPKMTDFGLPLPHMGWNRVYPQAGNRLFQGIEDGAYFYFVHSYAMPVNPWTIAQCNYGEPFTAAVQKDNFFGVQFHPERSGAAGAQLLKNFLEM
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_NEPAL
Sequence: MEELRGYLELDRSWQRDFLYTLILQEYIYSLAHDHGFNRTIFLENAGYEKKYSFLIVKRLITRMYQQNHLILSANDSNQNEFLGQKKNLYSQMISEGFAFIVEIPFSLQLLFSLEGKEIXXXXXXRSIHSIFPFLEDKFSHLNYVLDILIPHPVHLEILVQTIRYWTKDASSLHLLRFFLYEYRNWNSRISIKQYISFFSNRNQRLFLFLYNSHVCEYESIFIFLRNQPFHLRSTFSGAFLERILFYEKMEHLVKVFTKNFQVILWFFKDTFIHYVRYQGKSFVASKGTSLLMIKWKYYLVNFWQCYFSVWSQPRRIYINQLSNHSLDFMXFLSSVRLNPSVVRIQMFEKSFIIDNAINTFDTLVPNIHMSGSFAKEKFCNIFGHPISKPVWADLSDSDIIDRFGRICRSLSHYYSGSSRKKSLYRIKYILRLSCARTLARKHKSTVRTFLKRLGSEFLEEFFMEEEKVLSLILPRDSYTSQRFYRGRIWYLDIFCIHDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL10_GLOC7
Sequence: MGRTRENKEDVVADLKELLKESQLAVIIDYQGLSVAEITDLRRRIRPVGGTCKIAKNTLVRIAVDGDQNWQPMQEYLKGSSAVLLVQEDVGGIVKAYKSFQKDSKKTELRGGVMEGRSLTKDQVEALADLPSKEQLYAQIAGAINSITAKIAIGIKEVPSSVARGLQAYSEKEQGSES
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: GLPK_LISMC
Sequence: MEKKYILALDQGTTSSRAMIIDEEGEVIGVAQEEFDQIFPKPGWVEHNANEIWASILAVIAGVLLKTNISSKEIAGIGITNQRETTVIWDKESGNPIYNAIVWQSRQTEDICKQLRKDGYEDTIRSKTGLLIDPYFAGTKARWILDHVDGAQERAEKGELLFGTIDTWLVWKLTGGRAHITDYSNASRTLLYNIYDLEWDDELLKMLNIPKAMLPEVRPSSEVYADTVPYHFFGEEVPVAGIAGDQQAALFGQGCFEKGMAKNTYGTGCFLLMNTGEKAVRSENGLLTTLAWGIDGKVEYALEGSIFVAGSAIQWLRDGLRMVRQSSDSENYASRIESSDGVYVVPAFVGLGAPYWDSDVRGAVFGLTRGTEKEQFIRATLESLAYQTRDVLYAMEQDSGISLKTLRVDGGASANNFLMQFQSDILGVPVERPENKETTVLGAAFLAGLAVGVWKDKNEIKKHWKLDKRFEVEMKDEQREDLYEGWHKAVKAAQAFK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: ISPDF_ALIB4
Sequence: MLDVTLIVLCAGNSTRFEHKTKKQWIRVEDEPLWLNVTKRISSFAKFDKIIVTSHQDELNYMKNFSDDFTFVKGGETRQLSILNSLQFVTTKYVMITDVARACVPQSVIENLLNEKSSADCIVPILNVTDTVVYENDTIDRSNVKLIQTPQLSSTQVLRDALNTPIEFTDESSAIKAIDGKIKYIQGSTFSKKLTLGDELDELPCLKAPSNNFFTGTGFDIHAFEEIKDMYLGGVKLPYEYGFKAHSDGDVLIHSVIDALLGACGAGDIGEFFPDTDDKYKGIDSKLLLGQIVNFINNVGYEIVNVDLTIIAQKPKINPFKDEIKKSMAKLLRIEKQFVNVKATTAEKLGFIGRAEGVAVQSIATLKYYNWKKR
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: RIHA_SALNS
Sequence: MALPILFDCDPGHDDAIAIVLALASPELDVKAITSSAGNQTPDKTLRNVLRMLTLLNRTDISVAGGAVKPLMRDLIIADNVHGESGLDGPALPEPAFAPLDCTAVELMAKVLRESPEPVTIVSTGPQTNVALLLNSHPELHAKIARIVIMGGAMGLGNWTPAAEFNIYVDPEAAEIVFQSGIRVVMAGLDVTHKAQIHREDTERFRAIGNPVSTIVAELLDFFFEYHKDEKWGFIGAPLHDPCTIAWLLKPELFTTVERWVGVETQGKYTQGMTVVDYYFLSGNKPNATVMVDVDRQGFVDLLAERLQYYA
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihA, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihA subfamily.
Protein: SECM_YERPG
Sequence: MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPLNLSGVPDHAALANTSSSQSRQNHGTTNFNSLALLHDIHRRLSFSVDYWQQHALRTVIRHLSFALAPQAAYARVQEVAETERVAPSKIQQLALLDTLNALLTHEFKPPAIIRYTEQVERPVLSPYKPGLWLAQVQGIRAGPANLS
What is the function of this protein?
Regulates secA expression by translational coupling of the secM secA operon.  Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
What are the official names of this protein?
Secretion monitor.
What is the protein family that this protein belongs to?
Belongs to the SecM family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Protein: COX2_YEAST
Sequence: MLDLLRLQLTTFIMNDVPTPYACYFQDSATPNQEGILELHDNIMFYLLVILGLVSWMLYTIVMTYSKNPIAYKYIKHGQTIEVIWTIFPAVILLIIAFPSFILLYLCDEVISPAMTIKAIGYQWYWKYEYSDFINDSGETVEFESYVIPDELLEEGQLRLLDTDTSMVVPVDTHIRFVVTAADVIHDFAIPSLGIKVDATPGRLNQVSALIQREGVFYGACSELCGTGHANMPIKIEAVSLPKFLEWLNEQ
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable).  COX2 is a catalytic core subunit which transfers the electrons from cytochrome c via its dinuclear copper A center (CU(A)) to the BNC of the COX1 (PubMed:30598554).
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ZN135_BOVIN
Sequence: MTAGLLTAGDPDQVTFEDVVVDFTQEEWGHLEPAQRTLYRDVMLETFGLLVSVGHWLPKPDVISLLEQEAELWAADKGGPRGVCPDLETRPQSKLSTENQGVTEEIPNSALVERFLQESLWHSKDEGAAGHREQGPEKSDSCVVQAACTLVKTLTEEQQQGDGCGENLSLRPDLPTQPMTPERQGAPTWGTHGQRENPDSNAQQKTCAKEKPYGCQECGKAFSHSLALIEHHRTHTGERPYECPECGKGFRNSSALTKHQRIHTGEKPYKCAQCGRTFNQIAPLIQHQRTHTGEKPYECSECGKSFSFRSSFSQHERTHTGEKPYTCSQCGKAFRQSIHLTQHLRIHTGEKPYQCGECGKAFSHSSSLTKHQRIHTGEKPYECQACGKAFTQITPLIQHQRIHTGERPYECSECGRAFSQSTLLTEHRRIHTGEKPYGCNECGKAFSHSSSLSQHERTHTGEKPYACSQCGKAFRQSTHLTQHQRTHTGEKPYECSDCGKAFSHSSSLTKHQRIHTGEKPYECNECGKAFSQLAPLIQHQRIHTGEKPYECNQCGRAFSQSSLLIEHQRIHTKEKPYGCNECGKSFSHSSSLSQHERTHTGEKPYDCQDCGKSFRQRTHLTQHQRIHTGEKPYECRDCGKAFTHSSSFIKHQRTHTG
What is the function of this protein?
Plays a role in the regulation of cell morphology and cytoskeletal organization.  May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 135.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NFDA_ARTPS
Sequence: MTQMRDLMIINANVRTVDARNSCAQAVLVSGGRIAIVGTETEVRGAAAPDAEVLDVSGKTVVPGFIDAHNHLSVAAFAPDSVDCSTPPLATLDEVLEVIERHCRNIPPGQWVRGINFHASHIREQRNPTRYELDEVAPNNPFFLIDASCHAGFANSAALDLVGIGAHTPEPWGGEIERDLSGKPTGTLLEAAANLLHSASWNDYAERDWDRAVELLHSKMNDYLAVGLTGVGDAMVTAKSAELYRRADAAGKMPFTLQQLHGGDHFFSMQDLGRSDTVDRIMEPESYLLRGGAMKIFVDRAYPSPAIDQIHDGCKTHVGANFYSKSEVHDLAVRASKLGINLAIHGMGNCAIDIVLDAYEAVRRQSNADTVLRLEHAFIAETGQGQRMADLGIDLVANPGLAFGWGEVFNMWRGENQEHLKLFPVRSMLDAGVRVSLASDHPCGTYSPAEIMWTAVARETMAGAPLEPDEAVTADEALRMYTINPAHASGRGSEEGSIEAGKRANLLVLDRDPVDCATGELRELQVLRTYVDGVLRYERTGS
What is the function of this protein?
Hydrolyzes N-substituted formamides, but not amides.  N-benzylformamide is the preferred substrate, while N-butylformamide is hydrolyzed at a much lower rate.  Has very low activity towards allylformamide, N-(2-cyclohex-1-enylethyl)formamide and N-(alpha-methylbenzyl)formamide.
What are the official names of this protein?
N-substituted formamide deformylase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily.
Protein: TRPA_CITK8
Sequence: MERYENLFAQLKDRKEGAFVPFVTLGDPSVEQSLNIIDTLIEAGADALELGIPFSDPLADGPTIQEATLRAFAAGVTPTQCFEMLALIRQKHPTIPIGLLMYANLVFSKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRYNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLHHLVEKLQEYNAAPPLQGFGISSPEQVTGAIEAGAAGAISGSAIVKLIEKNVANPGQMLTELKAFVTAMKAATRA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: SPZ8_ORYSJ
Sequence: MDDGEAARRHRHRAISGGLTALAVRLADRLGAASPGRNLAFSPLSVHAALSLAAAGAAGGTLDEILAVLGAASRDDLAAFVGRTAETALADRGPESLGPRVVFAPGVWCDAARPFKPAYRAAVAAEYNAEATVVDFKNKVEEARKQINAWARRATGKLITDVLPPRSVGPETAVVLGNAIYFKGKWDRPFNESDTERKPFYRHDGAAAAAAVADVPYMSSRSYQRVAVHDGFKVLKLRYRSPRLLRDKRKRGGGGDVGGEFTRYAMAIFLPDARDGLRGLVERMASRPGFLHEHMPAAWPVPVGEFRVPKFKVSCGGSVVGALEQLGLRLPFSPELADLSDMVEDDGSGWPLFVGDIQHKAVIEVNEEGTVAAAATMTRMLPSGVPPPPVDFVAEHPFAYFIVEEMSSAVVFAGHIVDPSME
What is the function of this protein?
Probable serine protease inhibitor.
What are the official names of this protein?
Putative serpin-Z8, OrysaZ8.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
Protein: MURC_VIBPA
Sequence: MTIQHTQDLAQIRAMVPEMRRVKCIHFIGIGGAGMSGIAEVLLNEGYEITGSDLSENPVTERLVSKGATVFIGHQASNVEKASVVVVSTAINEENPEVMAARELRIPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAIVCIDDPVIRELIPRISRQVITYGFSDDADVRIENYHQEGQQGKFTVVRKGRANLDITLNIPGRHNALNASAAIAVATEDDIEDDAILKAMAGTQGTGRRFDHLGEFDTGNGHAMLVDDYGHHPTEVDVTIKAARSGWQDKRLVMIFQPHRYSRTRDLYDDFANVLEQVDVLIMLDVYAAGEKPIAGADGRSLCRTIRSRGKVDPIFVPEIEQLPSVLANVIQDGDLILTQGAGDVGKVAKQLANLELNINKMLG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y467_MYCLE
Sequence: MDVDALLQSIPPLAVYLLVSGVVGVESLGIPLPGEVVLVSAALLSSRHDLAVSSIGVGVVAVIGAAVGDSIGYAIGRRFGMPLFDHLGRRFPKHFGPGHVALVERLFNRWGVRAVFFGRFIALLRILAGPLAGALKMHYPRFLAANVSGAICWAGGTTALVYFAGMAAERWMERFSWIALIITVVVGIIAAILLRERTSRIIAELEMEYKNRRH
What are the official names of this protein?
Uncharacterized membrane protein ML0467.
What is the protein family that this protein belongs to?
Belongs to the DedA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CSN5_XENTR
Sequence: MAMAGSSVAQKTWELSNNMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKVSALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINTA
What is the function of this protein?
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.  In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins.  It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex.
What are the official names of this protein?
COP9 signalosome complex subunit 5, Signalosome subunit 5.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Protein: VP4_BTV2A
Sequence: MPEPHAVLYVTNELSHIVKSGFLPIWRLTGVESLNVLWLENGKYATDVYAYGDVSKWTIRQLRGHGFIFISTHKNIQLADIIKTVDVRIPREVAKSQDMKAFENEIGRRRIRMRKGFGDALRNKLFKMAIEFHGSEAETLNDANPRLHKIYGMPEMPPLYIEYAEIGTRFDDEPTDEKLVSMLDYIVYSAEEVHYVGCGDLRTIMQFKKRSPGRFRRVLWHVYHPIAPESSDPNVIVHNVMVDSKKDILKHMNFLKRVERLFIWDVSSDRSQMDDDEWESTRFAEDRLGEEIAYEMGGAFSSALIKHRIPNSRDEYHCISTYLLPQPGADADMYELRNFMRLKGYSHVDRHMHPDASVMKVVSRDVRKMVELYHGRDRGRFVKNRLFEHLHIVRKNGLLHESDEPRADLFYLTNRCNMGLEPSIYEVMKKSVIATAWVGRAPLYDYDDFALPRSTVMLNGSYHDIRILDGNGAILFLMWKYPDIVKKDLTYDHAWAMNFAVSLKEPIPDPPVPDISLCRFIGLRVESSVLRVRNPTLHETADELKRMGLDLSGHLYVTLMSGAYVTDLFWWFKMILDWSAQSKEQKLRDLKRSAAEVIEWKEQMAERPWHVRNSLIAALREYKRKMGIREGASIDSWLELLRHL
What is the function of this protein?
The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus.
What are the official names of this protein?
Core protein VP4.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP4 family.
What are the subcellular locations of this protein?
Virion.
Protein: RRAB_SHEDO
Sequence: MSMERQLKEQFAENREIVEALLGDGSDADSEYVIEHHFSSTNFDKLEKAAVDAFKLGFEVNDAEEMELEDGSEIFCFDAIANHKLDVALLDKACEQLMQVAHKQKVDYDGWGTYFIGDEIEEDDEEEQA
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity B.
What is the protein family that this protein belongs to?
Belongs to the RraB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLE1_DROME
Sequence: MDDMMRAMDCLNMAATLRNAALASATCTGRTLGEDREPIWVEGSRKTPEPPLPEESPAPEPNNEIPLLPKIDFEPNISCFPDLQAINASIVRRELEEEGKRCVRQQLKAIRDKQDAMRLSRETQQRKEERQRDQLQQKALRERNESLLIQKADQMTAAQLEAQQREQLALRQQIDQKLHKLALEGVSRCQRRFNQKYEGIAKILLSLNPETVKVCAAQNTQLKELGQKFEQLVSSVKMGNCEMQSQFLCSIIKAEEFCKSLDALELDIIKQLAEFSEQIQQQLKMEAAKKLEDERQRQQQQEEERQKLEEQQKLEEQEKLRKEKEESAAKEKQQEAETAKADAANVPAPLEPKSQDVPPAATATSTSVHPDRLKFYNDILALYQSKVDAVKPLQTEESLKQYRTGCQRAINLPLNAISAVSPQHLAQNFDKLYSFFAGQPTKVMNGTITINDHPLARDYCMLLMAKKFVSQTETAICSNPQAAFPFASVIITFWKLLPDFGKVFLAYMYKESPFLVPYVIPQQQGQTPEQYLKTIGYRLTDKNELEKPDIYLKRQTGLARLYAAVIISQGRKAAGPDECFELNEGWLWLAHMVHVKPLPDISATLIMEILQTLGFELWRTYGKQFVKLLVYIQNIYMPQLAAYDEGGPKTRLEMLLAKFLRERQIAQAVGVLPPGFW
What is the function of this protein?
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.  May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).
What are the official names of this protein?
mRNA export factor Gle1, Gle1 RNA export mediator, Nucleoporin Gle1.
What is the protein family that this protein belongs to?
Belongs to the GLE1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nuclear pore complex.
Protein: DACA_ECOL6
Sequence: MNTIFSARIMKRLALTTALCTAFISAAHADDLNIKTMIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTIGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADFAAGSQDAFVGLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQLNRNGLLWDNSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASLGVDKDVYLTIPRGRMKDLKASYVLNSSELHAPLQKNQVVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKLMFHHWFG
What is the function of this protein?
Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.
What are the official names of this protein?
D-alanyl-D-alanine carboxypeptidase DacA, DD-carboxypeptidase, DD-peptidase, Penicillin-binding protein 5, PBP-5.
What is the protein family that this protein belongs to?
Belongs to the peptidase S11 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space.
Protein: TRPI_PSEAE
Sequence: MSRDLPSLNALRAFEAAARLHSISLAAEELHVTHGAVSRQVRLLEDDLGVALFGKDGRGVKLTDSGVRLRDACGDAFERLRGVCAELRRQTAEAPFVLGVPGSLLARWFIPRLDQLNRALPDLRLQLSTSEGEFDPRRPGLDAMLWFAEPPWPADMQVFELAPERMGPVVSPRLAQETGLAQAPAARLLQEPLLHTASRPQAWPAWAASQGLAAEALRYGQGFEHLYYLLEAAVAGLGVAIAPEPLVRDDLAAGRLAAPWGFIETDARLALWVPARLHDPRAGRLAQWLREQLAG
What is the function of this protein?
Activates the expression of the trpBA genes, which encode the two tryptophan synthase subunits, and represses initiation at its own promoter.  Acts by binding to two adjacent sites in the intergenic region.  In the absence of the inducer indoleglycerol phosphate (InGP), TrpI binds to site I.  In the presence of InGP, TrpI binds to site I and site II.  Binding to site II is site I dependent.  InGP strongly stimulates binding to site II and is required for maximal activation of trpBA.
What are the official names of this protein?
HTH-type transcriptional regulator TrpI, TrpBA operon transcriptional activator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: YCIB_SALAR
Sequence: MKQFLDFLPLVVFFAFYKLYDIYAATSALIVATAIVLIYSWVRYRKIEKMALITFVLVAVFGGLTLFFHNDEFIKWKVTVIYALFAGALLMSQWVMKKPLIQRMLGKELALPQQIWSKLNLAWALFFIVCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGVYIYRHLPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.