PharMolix/UniProtQA huggingface dataset:
Protein: LMBL1_RAT
Sequence: MEGHSDMEIIRAVKGSATGEINVHLVARDSAGSHPHLPTTTFIIPTNAATLGLPSTALDVSYPREPVHVGAAERVAGSEPVTATILPQLSTGPGTNSTVRLLDWTGVSAPLAGSGMRFRINEYATQNMIEIERPRSPEQRHEGGTAGREADIQHPDVHKDPQEVIPQEPSVDAGSCKCQTCGPQQSIGLDVGSSGDRCPQPFQKRSVIVENSGCTVASELIKPMKKRKHKEYQSPSEESEPEAMKQGKGKDPDREPTPGTSENEEWSRSQLVSSEKKEGWSWESYLEEQKAVTAPVSLFQDSQAVTHNKNGFKLGMKLEGVDPQHPSMYFVLTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTKAQAAPKHLFVSQSHSPPPVGFQVGMKLEAVDRMNPSLVCVASVTDVVASRFLVHFDDWDDTYDYWCDASSPYIHPVGWCQKQGKPLTPPQDYPDPDSFCWEKYLEETGTSAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKLHFDGWSHNYDFWIDADHPDIHPAGWCSKTGHPLEPPLRPRESSSASPGGCPPLSHRSPPHTKTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSETTARKKNQSNLSPRKKPRHQGRIGRPPKYRKMPDEDFQALPPSVVHQSLFMSTLPTHADRPLSVCWEQHCKLLPGVAGISASAVSKWTIEEVFGFVQTLTGSEDQARLFKEEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNNDDVFK
What is the function of this protein?
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications.  PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription.  Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes.  Also recognizes and binds RB1/RB monomethylated at 'Lys-860'.  Participates in the ETV6-mediated repression.  Probably plays a role in cell proliferation.  Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity).
What are the official names of this protein?
Lethal(3)malignant brain tumor-like protein 1, H-l(3)mbt, H-l(3)mbt protein, L(3)mbt-like, L(3)mbt protein homolog.
What are the subcellular locations of this protein?
Nucleus. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex (By similarity).
Protein: TUS_ECOBW
Sequence: MARYDLVDRLNTTFRQMEQELAIFAAHLEQHKLLVARVFSLPEVKKEDEHNPLNRIEVKQHLGNDAQSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQVDNLSQAALVSHIQHINKLKTTFEHIVTVESELPTAARFEWVHRHLPGLITLNAYRTLTVLHDPATLRFGWANKHIIKNLHRDEVLAQLEKSLKSPRSVAPWTREEWQRKLEREYQDIAALPQNAKLKIKRPVKVQPIARVWYKGDQKQVQHACPTPLIALINRDNGAGVPDVGELLNYDADNVQHRYKPQAQPLRLIIPRLHLYVAD
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBP8_YARLI
Sequence: MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDTIRGFRRVRYVVMDEADRLLTPGFVPDLKTCMDLLPDPSKRQTLLFTATVTDAVRALKDRTGEKGPPFIHEIASDIAVPSTLTQSYLFLPGYVREAYLWAILTHPDNEKKSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDVTRVTNIEERVGTKMEKYDLIEDDKVVEEYLTPASTAKRQAVLDMEAENFGERKRIQRKKAGLDVDMKSKNKKPKRVAKGKSDKK
What is the function of this protein?
ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites.  Required for vegetative growth (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SIGS_STAAN
Sequence: MKFNDVYNKHHKIIHHLLKKYNISYNYDEYYQLLLIKMWQLSQIYKPSSKQSLSSFLFTRLNYYLIDLFRQQNQLKDVILCENNSPTLTEQPTYFNEHDLRLQDIFKLLNHRERLWLKLYLEGYKQFEIAEIMSLSLSTIKLIKMSVKRKCQHNFN
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival (By similarity).
What are the official names of this protein?
RNA polymerase sigma factor SigS.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: GSHAB_MANSM
Sequence: MNIQQIVKEKGLGLLFRQGTVGIEKESQRVHADGSIVTSEHPKAFGNRSYHPYIQTDFAESQLELITPPNKKIEDTLRWLSALHEVTLRTIDENEYIFPMSMPAGLPPEQEIRVAQLDNAADVAYREHLVASYGKAKQMVSGIHYNFQLDPKLVETLFNAQTDYKSAVDFQNNLYLKMAKNFLRYQWIPLYLLSATPTVEANYFKDGSPLKPNQYVRSLRSSKYGYVNAPDIIVSFDSIEKYVETLEHWVNSGRLIAEKEFYSNVRLRGAKKAREFLHTGIQYLEFRLFDLNPFEAYGINLKDAKFIHHFILLMIWLEETADQDAVELGRARLGEVAFEDPHSETAYRDEGEQIINQLIDMLKAIGAEQSAVEFAEEKLAQFANPGQTLCARLVDAIEQAGGYQQLGGEIAKRNKVQAFERFYALSAFDNMELSTQALMFDAIQKGLNMEILDENDQFLRLQFGDHFEYVKNGNMTSHDSYISPLIMENKVVTKKVLAKAGFNVPQSLEFTSVEQAVASYPLFEGKAVVIKPKSTNFGLGISIFQQGVHDKADFAKAVEIAFREDKEVMVEDYLVGTEYRFFVLGNETLAVLLRVPANVMGDGVHTVAELVAAKNDHPLRGDGSRTPLKKIALGEIEQLQLKEQGLTVDSVPAKDQLVQLRANSNISTGGDSIDMTDEMHPSYKDLAVGITKAMGAAVCGVDLIIPDLKKPAEPNLSSWGVIEANFNPMMMMHIFPYSGKSRRLTLNVLGMLFPELV
What is the function of this protein?
Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
What are the official names of this protein?
Glutathione biosynthesis bifunctional protein GshAB, Gamma-GCS-GS, GCS-GS.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.
Protein: TAL_LEPBA
Sequence: MNLFLDTANIDEIKKVHELGLLDGITTNPSIIAKSGRKFTEVIKEICSFVKGPVSAEVLATDAPTMIKEGLELSKIAENVVVKVPLIPEGMKAVKAFAEQGIQTNVTLCFTANQALLAAKAGATFISPFVGRLDDVGYDGLELISEIREIYDNYGIETQILAASVRHPIHFKEVALRGADCVTLPYSVFEMLFKHPLTDSGLAKFVEDSKKLNW
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_MYCA1
Sequence: MSSAEADSVPPEVRRQWQELAETVREHQFRYYIKDAPIISDAEFDALFNELLALEERHPELRVADSPTQLVGGAGFATDFAEAAHLERMLSLDDVFDTDELIAWSNRVENEIGKDPHYLCELKIDGVALSLVYRDGRLERAATRGDGRVGEDVTLNARTIDDVPERLSPSDDFPVPALLEVRGEVFFLLADFEALNASLVEDGKAPFANPRNSAAGSLRQKNPAVTARRKLRMICHGIGRTEGFSPKTQHEAYTALSVWGLPVAEQTARVRGLAAVQERIGYWGEHRYELQHEIDGVVVKVDDVALQRRLGATSRAPRWAVAYKYPPQEAQTKLLDIRVNVGRTGRVTPFAFMTPVKVAGSTVGLATLHNAAEVKRKGVLIGDTVMIRKAGDVIPEVLGPVVDLRDGTEREFVMPTTCPECGTPLAPAKEGDADIRCPNARSCPAQLRERVFHVAGRGALDIEGLGYEAATALLKAGVIADEGDLFALTEDDLLRTELFRTKAGTLSANGTRLLQNLQKAKKVALWRVLVALSIRHVGPTAARALATEFGDLDSIMSASTERLAAVEGVGPTIAAALTEWFTVDWHRAIVDKWRGAGVRMADERDASVPRTLEGLTVVVTGSLAGFSRDDAKEAILARGGKAAGSVSKKTDYVVAGDSPGSKYDKAVELGVPILDEDGFRKLLAEGPPETPAD
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: OAZ1_MOUSE
Sequence: MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQSTLTEAKQVTWRAVWSGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLQADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED
What is the function of this protein?
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels.  Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:16916800, PubMed:18508777).  Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (By similarity).  Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773).  Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.  SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.  Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338).
What are the official names of this protein?
Ornithine decarboxylase antizyme 1, ODC-Az.
What is the protein family that this protein belongs to?
Belongs to the ODC antizyme family.
Protein: CBIX_SULIA
Sequence: MLGVLLVLHGSKIPEWKDVGIKYAEYLSRYFNLVEFGFLEFNKPTLSEALSNLLAKGANKIVVVPLLFATGTHFKRDIPRLLGIDGDEKKIQYMGKEIEIIIADPLGFDEKIGEVLVKRVNETYNKNY
What is the function of this protein?
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
What are the official names of this protein?
Sirohydrochlorin cobaltochelatase, CbiXS.
What is the protein family that this protein belongs to?
Belongs to the CbiX family. CbiXS subfamily.
Protein: SYE_RUTMC
Sequence: MKSRFAPSPTGCLHIGGARTALFAWVWAKKQHGKFVLRIEDTDLERSNQASVDAILQGMNWLGLDYDEGPFYQTDRFNRYKQVVRQLLDEKKAYYCECSKERLQILHEDLIKQGKKVRYDGCCRDKNLNDGVVRFNNPEDGLVIFNDVIKGQISINNKELDDLIIVRSDGTPTYNLTVVVDDHDMQIDCVIRGDDHINNTPKQINLYQALGWHLPEFAHLPMILSSDGARLSKRHDAVSIMTYRDAGFLPEALLNYLARLGWSYGDQEIFSMDEIVKLFELKSINKAPASFNQDKLLWLNQKIIKNSSVENLLNNLTWHLQNQAITITNAPNIEAVVQYLQNRCKTLVDMAGEVKMFYQDFDTFDEKLAKRYLKDKTPLKHLFAKLEALRIWKANNIKQAVKEVCFELNISFGKVGQPFRLALSGNGNAGSIDIVAELVGKNKALSRLKMAIDS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_MICAN
Sequence: MKLSRKESVRRRHQRVRRKINGTAERPRLSVFRSNNHIYAQIIDDVAQHTLAAASTLEATLRGELESTATQEASAAVGKLVAQRALDKGIEQVVFDRGGNLYHGRVKALAEAARSAGLNF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CHLB_ACAM1
Sequence: MKLAYWMYAGPAHIGTLRVASSFKNVHGIMHAPLGDDYFNVMRSMLERERNFTPVTASVVDRHVLARGSQEKVVDNITRKDEEENPDLIVLTPTCTSSILQEDLENFVERASLSTQGDVLLADVNHYRVNELQAADRTLDQIVQFYIQKARKNGDLLEEKTAKPSVNIIGVSTLGFHNQHDCTELKRLMADLGIEVNEVIPEGASVHNLKRLPQAWFNLIPYREIGHMSAHYLEKEFGMPFVDITPMGVVETARCIRKIQEVLNAQGADVNYEEYIENQTLHVSQAAWFSRSIDCQNLTGKKAVVYGDNTHAAAMTKILAREMGIHVVWAGTYCKYDQEWFRKEVSEYCDEVLINEDHGAIGDAIARVEPSAIFGTQMERHVGKRLNIPCGVIAAPIHIQDFPIGYKPFLGYEGTNQVADLVYNSFTLGMEDHLLEIFGGHDTKEVITKGISADSDLGWSADGQAELNKIPGFVRGKVKRNTEKFARERNITEITAEVLYAAKEAVGA
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: RPOA_CHLPN
Sequence: MSDNAHNLLYDKFELPEAVKMLPVEGLPIDKHARFIAEPLERGMGHTLGNALRRALLIGLEAPAIISFAMTGVLHEYMAIEGVIEDVTNIILNLKGALLKKYPMQDSSLGRTTQVLKASISIDASDLAAANGQKEVTLQDLLQEGDFEAVNPDQVIFTVTQPIQLEVVLRIAFGRGYTPSERIVLEDKGVYEIVLDAAFSPVTLVNYFVEDTRVGQDTDFDRLVLIVETDGRVTPKEALAFSTQILTKHFSIFENMDEKKIVFEEAISIEKENKDDILHKLILGINEIELSVRSTNCLSNANIETIGELVIMPEPRLLQFRNFGKKSLCEIKNKLKEMKLELGMDLTQFGVGLDNVKEKMKWYAEKIRAKNIKG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: BABA2_PONAB
Sequence: MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHMPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.  The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.  May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins.  May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.  May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
What are the official names of this protein?
BRISC and BRCA1-A complex member 2, BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, Brain and reproductive organ-expressed protein.
What is the protein family that this protein belongs to?
Belongs to the BABAM2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: CU10_LIMPO
Sequence: LGEKGYSYSTGDSSVTVQHDTLPYSRYQGLYNYAHPGYNTYPYNQYQG
What are the official names of this protein?
Cuticle protein 10, LpCP10.
Protein: YXDL_BACSU
Sequence: MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGSGKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTIGENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIHKPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKDGELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL
What is the function of this protein?
Part of the ABC transporter complex YxdLM which could be involved in peptide resistance.  Responsible for energy coupling to the transport system (Probable).
What are the official names of this protein?
ABC transporter ATP-binding protein YxdL.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: 6PGD_BUCBP
Sequence: MAKQQIGVIGMAVMGRNLALNMERNQYTVSIFNRSLDITEKIILNNPNKNLFPFFSIKDFVLSLIVPRCIVLMIKSGVATDDTIKSLIPYLSKGDIIIDGGNTFYKDTIQRGYELLKIGVNLIGAGFSGGEKGALYGPSIMPGGRQEAYNYVSPILKKIASNSEGIPCVTYIGPDGSGHYVKMVHNGIEYGDMQLIAESYFILKTLLRLDNQSISKIFDIWNQGELNSYLIDITKDILIKKDDQNNYLIDCILDEGSSKGTGTWTTKSALDLNEPLTLITESVFFRYLSSLKSQRLLASKILCGPKDFFIVLNRDDFIEKIRQALYLGKIISYAQGFSQLNSASQKYNWNLKLGEISRIFQSGCIIRAKLLKNITQEYSSNNNFVNLLLTPYFREIANTYHSSLREIVSISVKYGIPIPALSSAISYFDSYRSAFLPSNLIQAQRDFFGAHTYKRIDKSGIFHTNWYS
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
Protein: TOLB_BRADU
Sequence: MNDARSITRRRFMTLTGSGLAMLGGGHAFAQGQPRLRIDPTEFQPVPIAITNFLPGSPSDGDVGNGVTQVITNNLKRSGLFAPIDQAAFIERISNIDVAPQFQNWKTINAQALVTGRMTRQPDGRLKAEFRLWDVVSGQQLAGQQYFTSPEYWRRIAHIISDQIYERMTGEKGYFDSRVVFVDETGPKERRVKRLAMMDQDGANVRYLTRGSDLVLTPRFSPNSQEITYMEFGQGDPKVYLFNIETGQREIVGNFPGMTFAPRFSPDGQRVIMSLQQGGNSNLFVMDLRSRSTTRLTDTPAIDTSPSYSPDGTRICFESDRGGRSQIYVMAAGGGAAQRISFSKDDTNATYSTPVWSPRGDYIAFTRQGGGQFSIGVMKPDGSGERLLTSGFHNEGPTFSPNGRVLMFFRDPGGSGGPSLYSVDISGRNELKVPTPGFASDPAWSPLLSSTAGQ
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RRG7_YEAS8
Sequence: MIKNYLGRRWLNNPAIQAYVKQNAAVAHSTVFQGNLYEYTVMRELSEKLRMTKLRKTGGAHDGGVDIKGSWPVDDIYWKISSLMPNLEMASNIKRTNSQNGFVLKPLKYRIIDHTFEPLKVLVQCKAFTKSKLSPREFRELVGTFTSLVSHSQRNKTVCIMCSPHMLTKDTLNLINNITLPLIYLRVEMLKEKTDGHFDLINSGKLINYYENSYASTLMQDCKISEWLKLKLYKNSDFNSEK
What are the official names of this protein?
Required for respiratory growth protein 7, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG7 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL6_MANSM
Sequence: MSRVAKAPVSVPAGVEVKLDGQLLTVKGKNGELTRTIHNFVEVKQDNNELTFSPRNDGAEANAQAGTTRALVNAMVIGVTEGFTKKLQLVGVGYRAQVKGNVVNLSLGFSHPVEHTLPAGITAECPSQTEIVLKGADKQLIGQVAADIRAYRSPEPYKGKGVRYSDEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: GYRA_SYNY3
Sequence: MTDSPDRLIATDLRNEMSQSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMREPLIDGHGNFGSVDNDPPAAMRYTESRLRPLSTNSLLRDIEAETVDFIDNFDGSQQEPTVLPARIPQLLINGSSGIAVGMATNIPPHNLGEVIDGAIALIRNPEITEQELMQIIPGPDFPTGAQILGRSGIREAYLTGRGSITMRGVASIETMEHPGRPDRDAIIVTELPYQTNKAALIERIADLVNDKKIDGIADIRDESDRDGMRIVIELKRDAYARVVLNNLYKQTPIQSNFGANLLALVNGTPEVLTIKKFLTVFWEFRIETITRRTRYELRKAEERDHLLQGLLIALDNLDAVIRLIRGAADTASAKTELVEGFSLSEVQADAILQMQLRRLTALEADKITAEHDELQTKIADFQDILARRERVNAIIEEELEQIKAIHATPRRTVIVQEDGELIDTDLIANDQALILLTEQGYIKRMPASTFGTQNRATRGKAAAKIKDDDGVEHFLSCCDHDKVLFFSDRGVVYSLNAYQIPIASRTARGVPIVQMLPIPKDEKITSLVSVSEFDDDTYFIMLTKQGYIKKTALSAFSNIRANGLIAISLVEGDQLRWVRLAKAEDSVIIGSQKGMAIHFKADQDELRALGRATRGVKSMRLRSGDALISMDILPSQVVANIAVGSEDEPDEDLGGDTDAILEESDNPGPWLLGVTMKGFGKRVPIGQFRLQHRAGLGVKAIRFKSKDDQLVALHVVNADDELMIVTNRGIIIRQSVNDISPQSRSATGVRVQRLDADDAIAAVALVPPSGEEELAEMSESEES
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H41_TETPY
Sequence: MAGGKGGKGMGKVGAKRHSKRSNKASIEGITKPAIRRLARRGGVKRISSFIYDDSRQVLKSFLENVVRDAVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4, major.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CPLX_DORPE
Sequence: MAAFIAKQMVGDQLKSVKAMGGDEGEKEGNENAEEEAAAIEEARREAEERRKEKHRKMEEEREEMRQTIRDKYGLKKKVKEEPEAEADLDEGRVGRKKKTKEELAAEANEEEDDDEFAKFPTDLSDLTTKVSELPQKMAASVGEVTEKCSLQ
What is the function of this protein?
Positively regulates a late step in synaptic vesicle exocytosis.
What are the official names of this protein?
Complexin, Synaphin.
What is the protein family that this protein belongs to?
Belongs to the complexin/synaphin family.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor. Cytoplasm, cytosol.
Protein: ARI3B_MOUSE
Sequence: MEPLQQQQQQQQQKQPQQPLLQMDAREKQGPQTRESQFLYASKLGTQPALLSITPGRPSGSSVLGPLARVPPATPVARMSEQSNVNSEPEEEEGGLEDEDGDDDVAEVAEKEAQAASKYFHMQKVTRQEPRATPMSSLLPVPGLSPQGQQTKEDHTKDASKAPPSVPTAGQPSWSLDEQLKQNGALAWSDDADGGRGREISRDFAKLYELDGDPERKEFLDDLFIFMQKRGTPINRIPIMAKQILDLYMLYKLVTEKGGLVEIINKKIWREITKGLNLPTSITSAAFTLRTQYMKYLYAYECEKKALSSPAELQAAIDGNRREGRRPSYSSSLFGYSPAAAAAAAAAAAAAAASAASAGTPALLSSPKIRFSILGLGSSSGTSASSPRIPPASTLRKGDGVPVPVPNRLAVSGTLAGQQAGNRPGPLEHLRERLESGEPPEKKASRLSEEEQRLVQQAFQRNLFSMARQLPMKIRINGREDRAEPSAPALNLTTSNIGSINMSVDIDGTTYTGVLFAQKPVVHLIAGSTPQSIGSSASSSNSSSSHCSPSPTSSRGTPSAEPSTSWSL
What is the function of this protein?
Transcription factor involved in the production of cranial mesenchymal tissues.  Favors nuclear targeting of ARID3A.
What are the official names of this protein?
AT-rich interactive domain-containing protein 3B, ARID domain-containing protein 3B, Bright and dead ringer protein, Bright-like protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: TEG6_EHV1B
Sequence: MLPANRAEHSSDAEPRDIGSHGRNHGGCYSSDCKLGLLVDISNVVSPLPLDLTWSSWETTSQPARSRSYLNTRTYTIRACCDLQTRLHAFFIGVFEKRDPEKQILLPDLTNFKCILNNPRIMQELATEHSVCSAPFSAATQYDCDEDGEESTINGLCFHCHCKTPFSLECWQAANSAQAKILSVARGITSAKERQRENKR
What are the official names of this protein?
Tegument protein UL55 homolog.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae HHV-1 UL55 family.
What are the subcellular locations of this protein?
Virion tegument. Host nucleus matrix.