PharMolix/UniProtQA huggingface dataset:
Protein: GET3_RAT
Sequence: MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSTQ
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase Get3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Guided entry of tail-anchored proteins factor 3, ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
Protein: RUVC_CHRSD
Sequence: MTGEGSATILLGIDPGSRITGYGVVDVATPTPRYVASGCIRIKSDQLAQKLAQVYAGIGELIGLHRPHEIAIEQVFMSKNADSALKLGQARGTAIVCAANHGLEVFEYAPTQIKQAVTGTGAATKEQVQHMVTAILGLDGVPQADAADALAIALTHAYARQGRSLPPSRGRRRSGSRQRWRDYRPS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: KPCD_RAT
Sequence: MAPFLRISFNSYELGSLQAEDDASQPFCAVKMKEALTTDRGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEDPMSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMCVQYFLEDGDCKQSMRSEEEAMFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGTLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQKASRKPETPETVGIYQGFEKKTAVSGNDIPDNNGTYGKIWEGSNRCRLENFTFQKVLGKGSFGKVLLAELKGKERYFAIKYLKKDVVLIDDDVECTMVEKRVLALAWENPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHGKGIIYRDLKLDNVMLDKDGHIKIADFGMCKENIFGENRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPAKRLGVTGNIRLHPFFKTINWNLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQTAFKGFSFVNPKYEQFLE
What is the function of this protein?
Truncated isoform 2 is inactive.
What are the official names of this protein?
Protein kinase C delta type, nPKC-delta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Mitochondrion. Endomembrane system. Note=Translocates to the mitochondria upon apoptotic stimulation. Upon activation, translocates to the plasma membrane followed by partial location to the endolysosomes.
Protein: CLPX_NITWN
Sequence: MSKVGTGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSLVKSRDGIPTPKEICKVLDDYVIGQGHAKKVLSVAVHNHYKRLNHQTKHNDVELAKSNILLIGPTGSGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENIILKLLQSADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFSGLEKIISARGRTTSIGFAAQVLAPEDRRTGEIFRHVEPEDLLKYGLIPEFVGRLPVVATLEDLDEASLKKILTDPKNALVKQYQRLFEMENIELTFADEALGAVARKAIERKTGARGLRSILESILLETMFDLPGLEGVEEVVISREVVEGTARPLYIYADRADRASETSASA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: TIG_CLOBA
Sequence: MEAKVEKIETNVVKLEIKVEAEKFDAALTKAYNKNKGKYNVPGFRKGKVPMAILKKMYGIEIFYDDAVNIAIDESYNEALKAEDIRPVDYPKVDIVEIGEGKELVYTATVTTYPEVEIGEYKGLDIKKPSYEVSEEEVEKQVKEMQSKNARVETKEEGTIADGNIAIIDFKGFVDGEAFEGGEGTDYPLEIGSGTFIDNFEEQLVGLAIGDKKEVNVTFPENYGKEELNAKPAMFEVTVKGIKVKELPELDDEFAKEVSEFDTLAELKENVKKRLEESNNERAEREFEEAVITSIIETSKIDLPEVMLTKEIDSMMKDLESRLQYQGLSLDQYMEFTGNTIEKMREFMKENAERKVKADIILEAVAKAEEVKATDEQLNERALELGRMYGPKDPKKMANILLKAQKAMIEKDIIIENTLKLIKESCK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: E2AK1_HUMAN
Sequence: MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFPFAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGGVG
What is the function of this protein?
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707).  Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707).  EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707).  Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity).  This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity).  Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity).  In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity).  It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity).  Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707).
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-controlled repressor, HCR, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, hHRI, Hemin-sensitive initiation factor 2-alpha kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Protein: YA00_THEMA
Sequence: MNEKEKIIEYWRRRARECLDDAKLLLKNERLHSAVNRIYYALFYQVSALLLAKGLSFSKHSGVLAAFNREFVKTGKVNKELGKFYNRMFEHRKTGDYGELVEFEEENVKDWIRKAEGFLDAIEKLIEDLKRA
What are the official names of this protein?
UPF0332 protein TM_1000.
What is the protein family that this protein belongs to?
Belongs to the UPF0332 family.
Protein: CYC_CYPCA
Sequence: MGDVEKGKKVFVQKCAQCHTVENGGKHKVGPNLWGLFGRKTGQAPGFSYTDANKSKGIVWBEZTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKSATS
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c iso-1/iso-2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: Y2732_MYCA1
Sequence: MSSTGSARTEGDSWDLASSVGATATMVAASRALASRGPDPLLDDRFAEPLVRAVGHPFFVRMLDGQIPLDTDDMPMTLQQRREQITVRTRFFDDFFRSATAAGIRQAVILAAGLDARAYRLSWPAGTVVFEVDQPEVISFKTDTLARLGAQPTAERRTVAVDLRDDWPTALRDTGFDSSARTAWIAEGLLPYLPPHAQDRLLDNITALSAPGSRLATENITDMRVFTDERARAMRSTWRQHGLDIDVAELVWLGERRPAGDHLEATGWSVTRLPTERVYADYGFELPDNEILREFRQAISYLSAELG
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MAV_2732.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: RISB_BURO1
Sequence: MEIGQYQPNLEGDGLRIGIVQSRFNEPVCNGLADACVEELERLGVTGEDVLLVSVPGALEIPLALQKLAESGQFDALIALGAVIRGETYHFELVSNESGAGITRIGLDFNLPIANAVLTTENDEQAVARMTEKGRDAARVAVEMANLTMALDQLGDDEDEEEDEDDEEERA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RL32_ACTPJ
Sequence: MAVQQNKKSRSRRDMRRSHDALTTAAVSVDKTTGETHLRHHVTADGYYRGRKVINK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: FTSA_HELPY
Sequence: MEHKEIVIGVDLGSRKICAIVAEFKEGILRIIGTAHQDSKEINSKAIKRGRINSLAHASNAIKEVINSAKKMAGLNADEDRNNPMPHFGEYHPKTKAIVSFSGAYTESIRDVTGVASTKDNVVTIDEINRAINSACAKAGLDNDKHILHALPYRFTLDKQEVNDPLGMSGTRLEVFIHIVYTEKNNIENLEKIMIQSGVEIENIVINSYAASIATLSNDERELGVACVDMGGETCNLTIYSGNSIRYNKYLPVGSHHLTTDLSHMLNTPFPYAEEVKIKYGDLSFEGGEETPSQNVQIPTTGSDGHESHIVPLSEIQTIMRERALETFKIIHRSIQDSGLEEHLGGGVVLTGGMALMKGIKELARTHFTNYPVRLAAPVEKYNIMGMFEDLKDPRFSVVVGLILYKAGGHTNYERDSKGVIRYHESDDYTRTAHQSSPTPHIHSSPTERNLSDLKAPSAPLNTAKNDDFLPIKPTEQKGFFKSFLDKISKFF
What is the function of this protein?
Cell division protein that is involved in the assembly of the Z ring.  May serve as a membrane anchor for the Z ring.
What are the official names of this protein?
Cell division protein FtsA.
What is the protein family that this protein belongs to?
Belongs to the FtsA/MreB family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Protein: OTC_ECOLU
Sequence: MSGFYHKHFLKLLDFTPAELNSLLQLAAKLKADKKSGKEEAKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLVYAGDARNNMGNSMLEAAALTGLDLRLVAPQACWPEAALVTECRALAQQNGGNITLTEDVAKGVEGADFIYTDVWVSMGEAKEKWAERIALLRDYQVNSKMMQLTGNPEVKFLHCLPAFHDDQTTLGKKMAEEFGLHGGMEVTDEVFESAASIVFDQAENRMHTIKAVMVATLSK
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLIT1_MOUSE
Sequence: MALTPQRGSSSGLSRPELWLLLWAAAWRLGATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENFLQAVPRKAFRGATDLKNLQLDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKGEFSCSGQGEAAGAPACTLSSGSCPAMCSCSSGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECSSLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCHLSWLGDWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQCPQECACLDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAIGANPLYCDCRLRWLSSWVKTGYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSSPCQNQGTCHNDPLEVYRCTCPSGYKGRHCEVSLDGCSSNPCGNGGTCHAQEGEDAGFTCSCPSGFEGPTCGVDTDDCVKHACVNGGVCVDGVGNYTCQCPLQYTGRACEQLVDFCSPDMNPCQHEAQCVGTPDGPRCECMLGYTGDNCSENQDDCKDHKCQNGAQCVDEVNSYACLCVEGYSGQLCEIPPAPRSSCEGTECQNGANCVDQGSRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPVDGPCHGHKCVHGKCVPLDALAYSCQCQDGYSGALCNQVGAVAEPCGGLQCLHGHCQASATKGAHCVCSPGFSGELCEQESECRGDPVRDFHRVQRGYAICQTTRPLSWVECRGACPGQGCCQGLRLKRRKLTFECSDGTSFAEEVEKPTKCGCAQCA
What is the function of this protein?
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors.  During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity).  SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
What are the official names of this protein?
Slit homolog 1 protein, Slit-1.
What are the subcellular locations of this protein?
Secreted.
Protein: MURD_LACPL
Sequence: MKSVEQYRNQKVLVLGLAKSGVNAARLLHKLGAFVTVNDKKKFDENPDAQELLSDGIKVITGGHPLSLLDEDFKVVVKNPGIPYSNPIVSGAQEKGIPVITEVELASQILAGELIGVTGTNGKTTTTTMITMMLNQRTNAGKAYVAGNIGVPASAIAQKATAADTMVTELSSFMLCGIQTLHPHIAVITNIYSTHLDYHGSRENYVKAKMRITMNQTANDYLVINWDSEEWRQLSKQSQATVVPFSRQANTKDGAYEEAGKLYFKDEYIMDAADIRIPGDHNVENALAAIAVAKLQAVPTAGIVQVLKTFTGVRHRTQYVETYQDRQFYNDSKATNLVSTEMALKGFDQPVILLAGGLDRGNTFEKLAPALKAHVKTLIVFGETAEKMADAGRLAGIQDIEFTDNCETAVPIAWQHSQAGDIIMLSPACASWDQYPNFEVRGDRFIKAIEQLTGKAEEN
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIB_SALPC
Sequence: MTPGEVRRLYFIIRTFLSYGLDELIPRMRLTLPLRLWRYSLFWMPNRHKDKLLGERLRLALQELGPVWIKFGQMLSTRRDLFPPQIADQLALLQDKVAPFDGRLAKAQIEEAMGGLPVEAWFDDFDIQPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIQADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFENSPMLYIPEVYSDYCSQNMMVMERIYGIPVSDVAALEKNGTNMKLLAERGVKVFFTQVFRDSFFHADMHPGNIFVSHEHPENPQYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEDFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALTRALKEKAPFWVEKMPEIPELVYDSLRQGKYLQHSVDKIARELQVNHVRQSQSRYLLGIGATLLLSGSFLLVNRPEWGLMPGWLMVGGVVVWLVGWRKTR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COBQ_CERS4
Sequence: MPAVMIQGTGSDVGKSLLVAGLCRAARRRGLSVAPFKPQNMSNNAAVTADGGEIGRAQALQARASGLEPLTDMNPVLLKPESDHGSQVIVQGRRVGTLRARDWFERKPALMAPVLESFARLTAAHDLVIVEGAGSPAEVNLRRGDIANMGFARTAGVPVVLAGDIDRGGVIAQLVGTQAVIDPEDAAMIAGFLVNKFRGDVRLFDEGYRLIEARTGWRGYGVVPFFPEAALLPAEDALDLGRPTGQGALTVAWLAFSRVANFDDLDPLKQEPGLTVRMVRPGQPIPAEADLVILPGTKSTRGDLAFLRAQGWDVDLRAHHRRGGRVLGICGGYQMLGRSVADPEGLEGAPGVTEGLGLLDVETVMHPDKRLTRVAGRHRASGAELTGYEIHIGATEGPDCARPFAEIEGRPEGATSADGRVVGSYLHGMFGADGFRRAFLESLGAATSDLAYDARVETVLDALADHLETHVDVAGLLALAR
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: MNMG_PHOPR
Sequence: MFYQENFDVIVVGGGHAGTEAALAAARMGQKTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKATDKGGIQFRTLNSSKGPAVRATRAQADRALYKAAVREVLENQPNLMLFQQAVDDLIVENDRVIGVVTEMGLKFRATSVVLTVGTFLGGKIHIGLENYSGGRAGDPPSIALASRLRELPFRVDRLKTGTPPRIDARTVDFSRLQAQHGDNPIPTFSFMGKTSDHPRQIPCYITYTNEKTHDVIRNNLDRSPMYSGVIEGIGPRYCPSIEDKVMRFADKNSHQIFIEPEGLTTHELYPNGISTSLPFDVQIQIVRSMDGFENAAIMRPGYAIEYDFFDPRDLKQTFETKFIDGLFFAGQINGTTGYEEAAAQGLLAGMNAALQSQGKEGWCPRRDQAYMGVLIDDLSTMGTKEPYRMFTSRAEYRLLLREDNADLRLTEIGREFGLVDDDRWARFNQKVENIEQERQRLKDIWINPNSDHVDEINKILKTPIAREANGEDLLRRPEITYKLLTQLEDFSPAHIDTQASEQVEIQVKYQGYIDRQKDEVEKSLRHETTKLPFDLEYSIVKGLSNEVIAKLTDAKPETIGMASRISGITPAAISLLLVYLKKHGMLKKGE
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SENP5_MOUSE
Sequence: MKKQKKILWKKGIHLAFSEKWNAGFGSFKKFYFPQNLCFLKAKLGRPVAWHRQVKHFQCNKGLHIQKTWIQDVPFCSKTKSGLATQNVSTLYPKVKRKDSKHFISSSRSLLKLQADKLLSSAKSLDHKYCREKSLLKAAPGLSANTVLGRANGHEPTTDPQASDFPMKFSGESQSPGDSGKTVVLNKHRKRVCHGCYQGLEHHRNRRPLIPKQFQLNQHRRVRASLMMYEKLSMIRFRYRIFRSQHFRTKSRVCKLRKAQRSWVQKVTGDHQENLRDNNTEGDNCNPVPSLEPKDPCRCQPYFPDMDSSAVGKGKNCHVPDGHTKENPVLDKEHGLDDTFPDQQNGCVAYNWDQSSSCPKWECTEQIHEIPLMEHPSSDKFSPETERALMALGQESGTSAVSDDREKLPVSGADKSVSSVDGPVSEEPAQNENFQMEEDGSLKQSILSSKLLDHPYCKSPLDAPLLCSEPKVENQMSGGKSSQTASPVDDEQLSTCLSGFLDEVMKKYGSLVPLSEKDVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNKHMLDMDDLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLITVTLSSRIISFYDSQGIHFKFCVENIRKYLLTEAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRVRKRIYKELCECRLLD
What is the function of this protein?
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins.  Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates.  Required for cell division.
What are the official names of this protein?
Sentrin-specific protease 5, SUMO/Smt3-specific isopeptidase 3, Smt3ip3, Sentrin/SUMO-specific protease SENP5.
What is the protein family that this protein belongs to?
Belongs to the peptidase C48 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TAP26_DANRE
Sequence: MAPFKQNAKNKGPIRGKQFNNKFQRGGLSHNAKRKRKWVPEDKVFDGSLKEGQGFAFKRKEKVKHEYNKLLRKERKRKQESKVQLQEEYPEHLKHLYLAERERLDEEEQEKKKKRCKGRAVEEDIEEDDDKLNKDLGSSSSEKNITNTSTDQTIAPASSNEPAQPESSHKTTFFQRKQNISSYQKTKQEYERIKEERARKREEILKDKAQREEALKKYKEKKIATYQLLKRKTKKGQPNLNLQMELLLQKIQAQRK
What are the official names of this protein?
Thyroid transcription factor 1-associated protein 26 homolog.
What is the protein family that this protein belongs to?
Belongs to the TAP26 family.
Protein: 4CL1_SOLTU
Sequence: MPMDTETKQSGDLIFRSKLPDIYIPKHLPLHSYCFENLSEFNSRPCLIDGANDRIYTYAEVELTSRKVAVGLNKLGIQQKDTIMILLPNCPEFVFAFIGASYLGAISTMANPLFTPAEVVKQAKASSAKIVITQACFAGKVKDYAIENDLKVICVDSVPEGCVHFSELIQSDEHEIPDVKIQPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENANLYMHSDDVLMCVLPLFHIYSLNSVLLCALRVGAAILIMQKFDIAQFLELIPKHKVTIGPFVPPIVLAIAKSPLVDNYDLSSVRTVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFDIKSGACGTVVRNAEMKIVDPDTGCSLPRNQPGEICIRGDQIMKGYLNDPEATARTIEKEGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLINHPDISDAAVVPMIDEQAGEVPVAFVVRSNGSTITEDEVKDFISKQVIFYKRIKRVFFVETVPKSPSGKILRKDLRARLAAGISN
What is the function of this protein?
Carboxylate--CoA ligase that may use 4-coumarate as substrate.  Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.
What are the official names of this protein?
4-coumarate--CoA ligase 1, 4CL 1, 4-coumaroyl-CoA synthase 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.