PharMolix/UniProtQA huggingface dataset:
Protein: GLHA_BOVIN
Sequence: MDYYRKYAAVILAILSLFLQILHSFPDGEFTMQGCPECKLKENKYFSKPDAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKATVMGNVRVENHTECHCSTCYYHKS
What is the function of this protein?
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH.  These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
What are the official names of this protein?
Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Follicle-stimulating hormone alpha chain, FSH-alpha, Follitropin alpha chain, Luteinizing hormone alpha chain, LSH-alpha, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, TSH-alpha, Thyrotropin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit alpha family.
What are the subcellular locations of this protein?
Secreted.
Protein: HSLV_ACTPJ
Sequence: MTTIVCVRKDGKVAIGGDGQATLGNCVEKGTVRKVRRMYKDKVVTGFAGSTADAFILRDLFEKKLELHQGHLIKSAVELAKEWRTERSLRKLEAMMIVANESEFLLVSGSGDVIEPEQDVLAIGSGGNYAKAAALALLRTENNLSAKEIVAEALKIAGDIDIYSNHNHVIEEV
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS21_LEGPA
Sequence: MPLQPFKTSNLLTMGVELELQLISLSNFDLTAASPDILELLGRSSFPGSFTPEITESMLEIATDVHEEYDQLLKQLFHIRDTLVTVGDRLNIGICGGGTHPFQMWSNQRIFNKTRFIEVSELYGYLTKQFTIFGQHIHIGCEDGNQALFLLHSLNRYIPHFIALSASSPFVQSKDTLYNSARLNSVFAFPLSGRAPFVLNWDEFSLGYFEKMEHTGIVKSMKDFYWDLRPKPEFGTIEMRVCDSPLTVERAAALACYMQALCSYLLENKEPLPHEDDYLVYNYNRFQACRFGLDGTLVHPKTYEQILLREDILTTLRRLKPYANQLNSTMALEHIYEITHKGSDASFLREKYAEHRTLESVVNESLKQFRSSK
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2-1, Gamma-glutamylcysteine synthetase 2-1, GCS 2-1, Gamma-GCS 2-1.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: RL16_STRP1
Sequence: MLVPKRVKHRREFRGKMRGEAKGGKEVSFGEYGLQATTSHWITNRQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKVMFEIAGVSEEIAREALRLASHKLPVKCKFVKREAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: C13AA_CAEEL
Sequence: MSVILLAIPTLFIGFISYYLWIWTYWRRRGIPGPLGYPLVGSFPKTLKSEYPQYLQIRDWTKLYGPIYGYTEGTIKTLIVSDIDIVRQIFVEQYDNFYGRKLNPIQGDPEKDERTNLFSAQGFRWKRLRAISSPTFSNNSLRKINVTVEDSAMELLRHIEEQTSEGQQIDMLQFYQEFTMDTIGRIAMGQTDSQMFKNPLLKFVRAIFGDNRKHIPLIGGVFPTLAQVFRFFMLKFPLLGAANFIHVNKTVVTAVQNRIDQRENDRKNGIEIGEPQDFIDLFLEARADDVEHFQENNGDFSKTSSYGNRQLTTQEIVGQCLVFLIAGFDTTALSLSYTTFLLATHPEVQKKLQEEIERECIEPSISFDHLSKLKYMDCIIKETLRLYPLGTMANSRRCMRATKLGNVEVEVGTMVQVDTWSLHTDTKIWGDDAKEFKPERWLDPNCDQVFQKGGYISFGLGPRQCVGMRLAYMEEKMLLAHILRKYTFEVGTKTEIPLKLVGRATTQPETVWMHLKQRI
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Putative cytochrome P450 CYP13A10.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FSH3_YEAST
Sequence: MSEKKKVLMLHGFVQSDKIFSAKTGGLRKNLKKLGYDLYYPCAPHSIDKKALFQSESEKGRDAAKEFNTSATSDEVYGWFFRNPESFNSFQIDQKVFNYLRNYVLENGPFDGVIGFSQGAGLGGYLVTDFNRILNLTDEQQPALKFFISFSGFKLEDQSYQKEYHRIIQVPSLHVRGELDEVVAESRIMALYESWPDNKRTLLVHPGAHFVPNSKPFVSQVCNWIQGITSKEGQEHNAQPEVDRKQFDKPQLEDDLLDMIDSLGKL
What is the function of this protein?
Serine hydrolase of unknown specificity.
What are the official names of this protein?
Family of serine hydrolases 3.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase 3 family.
Protein: MEND_MYCTO
Sequence: MNPSTTQARVVIDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: STEA4_RAT
Sequence: MEKTCADEFPLTVDSSEKQGVVCIFGTGDFGKSLGLKMLQCGYSVVFGSRNPQVSSLLPRGAEVLCYSEAASRSDVIVLAVHREHYDFLAELADSLKGRVLIDVSNNQKMNQYPESNAEYLAQLVPGAHVVKAFNTISAWALQSGTLDASRQVFVCGNDSKAKDRVMDIARTLGLTPLDQGSLVAAKEIENYPLQLFPMWRFPFYLSSGLCVFFFVYCAIREVIYPYVTGKTDSTYRLVVSIPNRVFPITALTLLALVYLPGILAAILQLYRGTKYRRFPNWLDHWMLCRKQLGLVALGFAFLHAIYTLVIPIRYYVRWRLRNATITQALTNKDSPFSSSTAWLSDSYLALGILGFFLFLLLGITSLPSVSNMVNWREFRFVQSKLGYLTLVLCTAHTLVYGGKRFLSPSILIWSLPSAYILALIIPCTVLVMKFILIMPCIDKTLTRIRQGWERKSKYAQSTLNGKSDI
What is the function of this protein?
Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane.  Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:23733181).  Can also reduce Cu(2+) to Cu(1+) (PubMed:23733181).  Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).  Associated with obesity and insulin-resistance (By similarity).  Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (By similarity).  Inhibits anchorage-independent cell proliferation (By similarity).
What are the official names of this protein?
Metalloreductase STEAP4, Six-transmembrane epithelial antigen of prostate 4.
What is the protein family that this protein belongs to?
Belongs to the STEAP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: IBMP_CAMVN
Sequence: MENIEKLLMQEKILMLELDLVRAKISLARANGSSQQGDLPLHRETPEKEEAVHSALATFTPTQVKAIPEQTAPGKESTNPLMASILPKDMNPVQTGIRLAVPGDFLRPHQGIPIPQKSELSSTVAPLRAESGIQHPHINYYVVYNGPHAGIYDDWGCTKAATNGVPGVAHKKFATITEARAAADAYTTSTQTDRLNFIPKGEAQLKPKSFAEALTSPPKQKAHWLTLGTKRPSSDPAPKEISFAPEITMDDFLYLYHLGRKFDGEGDDTIFTTDNEKISLFNFRKNADPQMVREAYAAGLIKTIYPSNNLQEIKYLPKKVKDAVKRFRTNCIKNTEKDIFLKIRSTIPVWTIQGLVHKPRQVIEIGVSKKVVPTESKAMESKIQIEDLTELAVKTGGQFIQSLLRLNDKKKIFVNMVEHDTLVYSKNIKDTVSEDQRAIETFQQRVISGNLLGFHCPSICHFMERTVEKEGGSYKVHHCDKGKAIVQDASADSGPKDGPPPTRSIVEKEDVPTTSSKQVD
What is the function of this protein?
Enhances the ribosomal termination-reinitiation event leading to the translation of major open reading frames on the polycistronic viral RNAs.
What are the official names of this protein?
Transactivator/viroplasmin protein, Tav, Inclusion body matrix protein.
What is the protein family that this protein belongs to?
Belongs to the caulimoviridae viroplasmin family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in cytoplasmic occlusion bodies.
Protein: RS4_XYLF2
Sequence: MARYIGPSCKLARREGADLSLKSPSRALDSKCKLEQRPGQHGAVRKSKLSDYASQLREKQKVKRIYGVLERQFRNYYKNASTKKGNTGENLLQLLETRLDNVIYRMGFAVTRPAARQLVSHRSVLVNGKMVNLPSYHVKPGDVVALSQRAQKYLCVQESLTIKDQHGSAFSWIEVDSEKFSGVFKALPDRADLPSDINEALIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RL2_NITMS
Sequence: MGKRPLVRRRGRGGNQFRSTSTGKVGTKANYPRFPLSEQHEGEIIDLVHERGREAPLAKVRFEDGSVSFVPAVLGAKVGETLQFGLKSKIEKGNVISIQNIPDGTIVCNIEKHFGDGGAIVKSAGTDATVFSHGDEGVTVKLPSGKFTTLNPKNRAMIGTLAGGGASERPFMSAGGKWRNFKAKGKKYPIVRGVAQAAYVHPHGGGRHQHVGQSSTVSRDTPPGAKVGSIAARKTGRARIKERK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: LSPA_XANAC
Sequence: MSQRPNPSALIWLLLSALVVGLDQWSKAWVLSSLPEYTPVPVIDGFWNWYRTYNTGAAFSFLSDAGGWQLWFFTALAVGISGLLAFWLSRTARGQWRSALPYALVIGGAIGNVIDRLMHGHVVDFIQWYIGSHTWPSFNIADSAIVGGAIGIAVFGLFDKSDKQQPGTGNLR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSRQ_SALAR
Sequence: MRLTAKQIIWLKVCLHLVGFLPLLWLFWAINQGGLSADPVKDIQHFTGRTALKFLLATLLISPLARYAKQPLLIRTRRLLGLWCFVWATLHLTSYALLELGIHNLALLGSELISRPYLTLGIISWLALLALTLTSTQFAQRKLGKRWQTLHNVVYLVAILAPVHYLWSVKVLSPQPVIYAALALVLLALRYRKFRQWRR
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PAIP2_RAT
Sequence: MKDPSRSSTSPSIINDDVIINGHSHEEDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVPGVKY
What is the function of this protein?
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs.  Its inhibitory activity on translation is mediated via its action on PABPC1.  Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1.  Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity).
What are the official names of this protein?
Polyadenylate-binding protein-interacting protein 2, PABP-interacting protein 2, PAIP-2, Poly(A)-binding protein-interacting protein 2.
What is the protein family that this protein belongs to?
Belongs to the PAIP2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNCH_TRIV2
Sequence: MPFTYHRTIHFQDTDAAGVVYFANILSICHEGYEASLRTSGISLKEFFTNPNMAFPIVHASVDFLRPLFCGDQVIISLVPQKIGAEKFEINYEIYLADVLVAKAVTRHVCIDANTRSKQELSTEIIQWLDGYRKETEEVERRKAREVV
What is the function of this protein?
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA hydrolase, DHNA-CoA hydrolase, DHNA-CoA thioesterase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
Protein: LPXC_HELHP
Sequence: MKQKTIKNKVELVGIGLHKGVPVKMELEPLEVDSGIVFYRSDLGVSIEFKAENVIDTTMATVIAKGEAKISTIEHLLSAIHAYGIDNIRISLDNEEVPIMDGSAIGYCMLLEEAGIVAQNAPKKAIVIKKSIEIVDEKKFVRVEPSERTIFDFKIDFNHPVIRQQHYKFTFSTQAYKEEIARARTFGFLHEVNYLRSKGLAKGGDLSNCIVLDESSILNKEGLRYKEEFVRHKILDAIGDMALLGMPLLGSYISFAGSHKLNHLLTKQILSDEKAYEVVSLEDKVEEAALDYAFLHEQH
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: AROA_SHESR
Sequence: MKQLRLEPVVQVRGEINIPGSKSISNRALLLATLAKGTTTLTNLLDSDDIRHMLASLKQLGVGYRLSQNNTVCELTGLGGAISADTAQTLFLGNAGTAMRPLCAALTLGRGEFTLTGEPRMEERPIGDLVDALKQLGANIMYLKNEGFPPLTINATGLNGGDVEIAGDLSSQFLTALLMVAPLAKGSVNIHVKGELVSKPYIDITLALMAQFGVQVINHDYARFEILAGQQYVSPGKVLVEGDASSASYFLAAGAIKGGEVKVTGVGRLSIQGDVKFADVLEKMGADIEWGDDYIIARGAPLTAVDLDMNHIPDAAMTIATAALFAKGTTTIRNIYNWRIKETDRLAAMATELRKVGALVEEGHDYIQITPPAVLNTAEIDTYNDHRMAMCFSMMAFADCGITINDPDCTSKTFPDYFAQFASLKA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_ECO5E
Sequence: MSGTLLAFDFGTKSIGVAVGQRITGTARPLPAIKAQDGTPDWNLIERLLKEWQPDEIIVGLPLNMDGTEQPLTARARKFANRIHGRFGVEVKLHDERLSTVEARSGLFEQGGYRALNKGKIDSASAVIILESYFEQGY
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAJQ_SHIBS
Sequence: MPSFDIVSEVDLQEARNAVDNASREVESRFDFRNVEASFELNDASKTIKVLSESDFQVNQLLDILRAKLLKRGIEGSSLDVPENIVHSGKTWFVEAKLKQGIESATQKKIVKMIKDSKLKVQAQIQGDEIRVTGKSRDDLQAVMAMVRGGDLGQPFQFKNFRD
What are the official names of this protein?
UPF0234 protein YajQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: HSLU_ECO45
Sequence: MSEMTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNNWGQTEQQQEPSAARQAFRKKLREGQLDDKEIEIDLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDAMKLLIEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNESTENIGARRLHTVLERLMEEISYDASDLSGQTITIDADYVSKHLDALVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Heat shock protein HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_CERS5
Sequence: MAQSYVGQKRIRRYYGKIREVLEMPNLIEVQKSSYDLFLKSGEGPKAADGEGIQGVFQSVFPIKDFNETAVLEFVKYELEKPKYDVDECQQRDMTYAAPLKVTLRLIVFDVDETTGARSVKDIKEQDVYMGDMPLMTANGTFIVNGTERVIVSQMHRSPGVFFDHDKGKTHSSGKLLFACRIIPYRGSWLDFEFDAKDIVFARIDRRRKLPVTTLLYALGMDQEGIMDAYYDTVDFKYQKNRGWVTRFFPERVRGTRPTYDLVDAATGEVILKAGEKATPRMVKKWIDDAQITELLVPFDHIVGRYVARDIINEETGEIWVEAGDELTMEYDRDGEVKGGTLKLLLDQGITDIPVLDIDNVNVGPYIRNTMAADKNMGRDTALMDIYRVMRPGEPPTVEAAAALFDTLFFDSERYDLSAVGRVKMNMRLDLGKPDTQRTLDRDDIIACIKALTELRDGKGEIDDIDHLGNRRVRSVGELMENQYRVGLLRMERAIKERMSSVEIDTIMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRMCPIETPEGQNIGLINSLATFARVNKYGFIETPYRKVIEGQVTDDVVYMSATEEMRHTVAQANATLDEEGRFVSDLISSRKAGEFMLNPPDAIDLIDVSPKQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLQSDAPFVGTGIEAVVARDSGAAIMARRAGVIDQVDATRIVVRATEMLEPGEPGVDIYRLRKFKRSNQSSCINQRPLVKVGDVVHRGEVVADGPCTDMGELALGRNVVVAFMPWNGYNYEDSILISERILRDDVYTSIHIEEYEVAARDTKLGPEEITRDIPNVGEEALRNLDEAGIVYIGAEVQPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGAYGTIVEVRVFNRHGVDKDERALQIEREEVERLARDRDDELAILERNIYSRLKTLIMGKVAVKGPKGIKAGSEINDELLSTLSRGQWWQLALGEEADAKEVEALHEQFEAQKRALDHRFEDKVEKVRRGDDLPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVISKVVPIEDMPFLADGTHVDLVLNPLGVPSRMNVGQILETHMGWAARGLGIQIDEALQDYRRSGDLTPVKEAMRLAYGDETYEGAFADRDDEDLVEMASRVTKGVPIATPVFDGAKEPDVNDALRRAGFDQSGQSIVFDGRTGEQFARPVTVGVKYMLKLHHLVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRLGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKMYESIVKGEDNFEAGVPESFNVLVKEVRGLGLNMELLDADEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: DAPE_EHRRW
Sequence: MVIDPVTLSQELISFPSITPTDNGAISFLSDILSQYGFTCHILDFGDDTVTVRNLYAYRGTEEGPNLCFAGHTDVVKTGDLTKWKFDPFSGHIEDDILYGRGAVDMKSAICAFIAAVSRINFNEVPGSISFLISGDEEGDHFQYGTPSVLKWLNENNHKIDYCIIGEPTSKSFLGDTIKVGRRGSVHFKIICNGIQGHVAYPHFAENPIDNMVSILYKICNTTFDTGNEYFQPSNCEIVSVDTGNTSKNVIPDTIVAHINIRYNNIHTAESLFDIINNICAQVTPKYQLLQSVSGEPFFNQPNQYSDMLSSAIKKVTGQDAIASTSGGVSDSRFIKNVCPVIEFGLKNETAHKIDEHVPVKEIYQLADIYTEFIKQFFNLSTT
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: HIS8_RHOJR
Sequence: MTAANVPGSSIGVDALPIRENLRGKSAYGAPQLTVPVQLNTNENPHPPTKALVDDVAESVREAARELHRYPDRDAVALRTDLAAYLVRQTGVPVTVDNVWAANGSNEILQQLLQAFGGPGRSAMGFVPSYSMHPIIADGTETEWLPIFRRADFALDVDAATAAITERRPDVVFVTSPNNPTGHSVGIAELRRVLDAAPGIVIVDEAYAEFSDAPSALTLIDEYPSKLVVSRTMSKAFAFAGGRLGYLAAAPAFIEALLLVRLPYHLSVVTQAAARAALRHANETLASVHALATERVRVSKALDDTGFRVIPSDANFILFGEFTDSAHAWRAYLDRGVLIRDVGIPGYLRATVGLASENDAFIVASDEIAATELTSSGDRG
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: PEPQ_ECOSM
Sequence: MESLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPNSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: UBP30_HUMAN
Sequence: MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
What is the function of this protein?
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951).  Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951).  Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291).  Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 30, Deubiquitinating enzyme 30, Ubiquitin thioesterase 30, Ubiquitin-specific-processing protease 30, Ub-specific protease 30.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane.
Protein: COBT_JANSC
Sequence: MTTPTTLVEFQTALAAATGPDDAARAGAAERNGQLTKPPGALGLLEDLAIWYAGWRGDARPRITAPQVLVFAGNHGVAARGVSAFPPEVTVQMVANFAHGGAAINQLSDLAGATMSVHPIDLETPTADFTQGPAMSEAGVMAAIAVGWEAVDTDADLLVVGEMGIGNTTSAAAVANALYGGAPEDWTGRGTGVDEAGIALKSRIVAEGLAVNPEAATDPLQALRCLGGRELAAMAGAIAHARILHIPVILDGFICTAAAAVLECAVSGALDHAIAGHGSAEQAHARMLHHLGKTPLLQLGLRLGEGSGGALAIQILRGAIACHSGMATFAEAGVAGG
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.