PharMolix/UniProtQA huggingface dataset:
Protein: PLP3_ORYSJ
Sequence: MEAGQDDAADRLTYEIFSILESKFLFGYGGGGGGETKSLQCAPPVSRGNRVCVLSVDGGARPEDGLLAAAALVRLEAAVQRRAGSKAARLADFFDVAAGSGAGGVLAAMLFARGPCGRPMYSADDALGFLLRRVRRRGWSSRAGGLLRRPAGAFHKVFGELTLRDTVRPVLVPCYDLATRAPFLFSRADAAQSPAYDFRLRDACAATCAPSGGGAAVEASSVDGVTRITAVGSGVALGNPTAAAITHVLNNRREFPAAAGVDNLLVISIGTGEAAGSSSRHRARTPVIARIAAEGASDMVDQAVAMAFGQHRTSNYVRIQGMGVARRRGGGVACGGETAEKAVWVAEAMLQQRNVEAVMFQGRRLAGETNAEKVERFARELIKEHGRRKQHVPPAASGGGGGGLDCHVSKKQP
What is the function of this protein?
Possesses non-specific lipolytic acyl hydrolase (LAH) activity.  Hydrolyzes phospholipids as well as galactolipids.  May play a role in disease resistance (By similarity).
What are the official names of this protein?
Patatin-like protein 3, OsPLP3.
What is the protein family that this protein belongs to?
Belongs to the patatin family.
Protein: PSBD_MANES
Sequence: MTIALGKFTKDENDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFAVGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CHR12_ARATH
Sequence: MVAQQLQERCGGTSQEDPVETTKSLICALNYISRDLPLPPHLFTAVSSIYHGASSSSLSDSDVSPPLPTSPPANKAPYGADLMGEFEDALLKQRPDCESGSRLIQLLDNRNKSHIQRRLSELEELPSTRGEDLQAKCLLELYGLKLRELQGKVRTAVSSEFWLRLNCADVSSQVFDWGMMRLPRPFYGVGDPFAMEADDQFRKKRDAERLSRLEEEEKNLIETAKRKFFAEVLNAVREFQLQIQATQKRRRQRNDGVQAWHGRQRQRATRAEKLRLMALKSDDQEAYMKLVKESKNERLTTLLEETNKLLANLGAAVQRQKDAKLPEGIDLLKDSESDLSELDAPRSEPLQDLLPDQDIDITESDNNDDSNDLLEGQRQYNSAIHSIQEKVTEQPSLLEGGELRSYQLEGLQWMVSLFNNNLNGILADEMGLGKTIQTISLIAYLLENKGVPGPYLIVAPKAVLPNWVNEFATWVPSIAAFLYDGRLEERKAIREKIAGEGKFNVLITHYDLIMRDKAFLKKIEWYYMIVDEGHRLKNHESALAKTLLTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSVQNFEEWFNAPFADRGNVSLTDEEELLIIHRLHHVIRPFILRRKKDEVEKFLPGKTQVILKCDMSAWQKVYYKQVTDMGRVGLQTGSGKSKSLQNLTMQLRKCCNHPYLFVGGDYNMWKKPEIVRASGKFELLDRLLPKLRKAGHRILLFSQMTRLIDVLEIYLTLNDYKYLRLDGTTKTDQRGLLLKQFNEPDSPYFMFLLSTRAGGLGLNLQTADTVIIFDSDWNPQMDQQAEDRAHRIGQKKEVRVFVLVSVGSVEEVILERAKQKMGIDAKVIQAGLFNTTSTAQDRREMLEEIMRKGTSSLGTDVPSEREINRLAARSEDEFWMFERMDEERRRKENYRARLMQEQEVPEWAYTTQTQEEKLNNGKFHFGSVTGKRKRKEIVYSDTLSELQWLKAVESGEDLSKLSMRYNRREENASNTKTSTSKKVIESIQTVSDGTSEEDEEEQEEERAKEMSGKQRVDKSEEEEEEGEEENDGKAIFKWNTHKKKRSRYSFTCSSSDSRAQSSNGSRRK
What is the function of this protein?
Probable chromatin-remodeling factor that is functionally redundant with CHR23 in root and shoot stem cell initiation, and root apical meristem (RAM) and shoot apical meristem (SAM) maintenance.  Plays an important role in mediating the temporary plant growth arrest induced upon perception of stress (PubMed:17605754, PubMed:23062007).  May promote seed maturation and repress initiation of germination (PubMed:24839909).
What are the official names of this protein?
Probable ATP-dependent DNA helicase CHR12, Protein CHROMATIN REMODELING 12, AtCHR12, Protein MINUSCULE 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: METE_DICDI
Sequence: MVSSSNLGFPRMGENRELKKLVENYWQGKVEETQFQKELKEIRINHWKLQKEAGIEIIPSNDFSLYDQVLDHIHLFGAIPKRYTPVVESEIEDGSNGLRTYFAMGRGYQTSKAATQVSETNTQGAFASKVEKSIDVGSMEMKKWFDTNYHYIVPEFEDSQQFKLTNYGGYSEPKPIHEFLEAKSIDIETRPVVLGPISFLLLGKSSDSSKPYSSKFDSLVHLNALLGVYEELFKQFEKIGVKSVQIDEPVLCFDLFETELIKNAYTTAFNVIHKAAPNINILIATYFGEIRENIDLITSLPVNGIHIDTIRSSSSEVESVLTKIPTSWTISIGIIDGRNVWKNDLTKSLVTLKNIIAKTGSDRILLAPSCSLLHCPHSLTREIGRVESQVLDWLAFSLEKLKEISFLTYALNKCTFTTENTITFPEDTCSKIKEYYQLNKESNQKRRESKLIHNDIVKKRVTEITPSMLKRENPFPVRREAQRKRLTTLPALFPTTTIGSFPQTKEVRLARSNFKSKKITPEAYDQFIRDEIRKCIKVQEECELDVLVHGEFERTDMVEYFGEYLAGFVFTQNGWVQSYGSRCVKPPIIYGDVNRPVPMTLEYTTFAQTLTTKPMKGMLTGPVTILQWSFVRDDQPRSETCFQIGLAIRDEVTDLENKGIACIQIDEPAIREGLPLRLSDWNQYLKWAIDSFLLSSTGVKDSTQIHSHMCYSDFNDIFESIQRMDTDVLTIENSKSDLKLLKAFEKYGYTNEIGPGLYDIHSPRIPSVEDMKDRVEQMLKYLSTNLLWINPDCGLKTREPETTRLALINMVKVAKQFREIYANKE
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: HSCB_BURTA
Sequence: MVSLKDSHFELFHLPAQFALDEPTLDAAYRAVQSQVHPDRFAAAGDAQKRVAMQWATRANEAYQTLRDPLKRATYLLHLRGVDVGAENNTAMEPAFLMQQMEWRERIEDAAAAKNVGELDALLDELRDERRARLAKLGSLLDSGSDQGAAEAVRQLMFVERVSAEIGAQIERLEH
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: CH60_LACGA
Sequence: MAKDIKFSENARRSLLKGVDKLADTVKTTLGPKGRNVVLEKSYGAPDITNDGVTIAKSIDLKDHFENMGAKLVSEAAQKTNDIAGDGTTTATVLTQAIVREGMKNVTAGANPVGIRRGIETATKAAVDELHKISHKVSTKDEIAQVASVSSASTEVGNLIADAMEKVGHDGVITIEESKGIDTELSVVEGMQFDRGYLSQYMVTDNDKMEADLDNPYILITDKKISNIQDILPLLQEIVQQGKSLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVISSDLGLELKDTKIDQLGKAGKVTVTKDSTTIVEGAGSKDAISERVDQIKKQIADTTSDFDREKLQERLAKLAGGVAVIKVGAATETELKERKYRIEDALNATRAAVEEGYVAGGGTALVDVMKSIQGNVKGDSQDAQTGVNIVMKALGAPVRQIAENAGKDGAVILDHLEHEDPEIGYNAATDKWENMVKAGIIDPTKVTRSALQNAASIAALLLTTEAVVADAPEDDKNQAPAAPNPGMGMGM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3608L_ASFWA
Sequence: MLSLQTLAKKAVAKQSVPEEYHYILKYCGLWWQNKPISLCHYCNYVILSSTPFKGELLHLDVALIMAIKENNYDVIRLFTEWGANIYYGLTCARTEQTQELCRQLGAKDSLNNKEIFTGLMRHKTSNNIILCHEIFDKNPMLETLNVQEMGEEIHRELKLFIFYILDNVPMNVLIKYWYAIAVKYKLKRAISFFYQTYGHLSMWRLMCAIYFNNVFDLHEIYEQKIVHMDIDKMMKLACMQDYNFLTIYYCFVLGGDIDKAITVTQWHHQTNNLYFCKDLKDLKQNILTARPLLLPNITDPKKIYTMLKNYLPTSSNSL
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-8L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: SURE_MAGSA
Sequence: MTFPPVADPSSLRILISNDDGINAPGIKVLERIARTLSKDVWVVAPETEQSAAGHSLTIRRPLRVRKVSARRYAVDGTPTDSVLLGVNHVLKGKKPDLVLSGINRGANLGEDVTYSGTVAAAMEGTILGIPAIALSQTLEHPHPVKWGTVEHWAPDVIRRLLAKGWSRNVLINVNFPDVIAASVTGIEITRQGKRKIGDEIMERHDPRGEAYVWIGAQRAEDRSKPGTDIEAVFRGAISVTPLCFDLTHRDDMKALETAF
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_ACICJ
Sequence: MARAKICGLRTRETWLAATDAGADWVGFVFFPRSPRFVTIEALKAIGADARVPRVGLFVDPEPAAIEAVLKVQDLEFLQIYAGAEACRAMRARFGAKVWRAVGVASAADLPRDDEGLDGFLIESKPPRGADRPGGNATAFDWAVMQGWRAPAPWLLAGGLTPANVAAAVRASGAAAVDVSSGVESAPGEKSVPLIRDFVAAAHAA
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: GNRHR_RAT
Sequence: MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
What is the function of this protein?
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH).  This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CCME_PSEMY
Sequence: MNPVRKKRLYIVLAILCGVSIAVALALTALQENINLFYTPSQIANGEAPEGTRIRAGGLVEEGSVKRSPDTLEVDFVVTDGAHGVTIRYHGILPDLFREGQGIVALGRVNEDGVLVADEVLAKHDENYMPPEVMQALEKSGMMQKHNEAKAAKGYQQESAQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: SBCC_STAA3
Sequence: MKPLHLKLNNFGPFLKEEIDFSKIDNNELFLISGKTGSGKTMIFDAMTYALFGKASTEQREENDLRSHFADGKQPMSVTFEFQLNHRIYKVHRQGPYIKEGNTTKTNAKFDVFEMVDGKYEIRESKVISGTQFIIELLGVNADQFRQLFILPQGEFKRFLISNSREKQGILRTLFDSEKFEAIREILKEEVKKEKAQIENRYQQIDLLWQEIESFDDDNIKGLLEVATQQIDKLIENIPLLQARSKEILASVNESKETAIKEFEIIEKKTLENNILKDNINQLNKNKIDFVQLKEQQPEIEGIEAKLKLLQDITNLLNYIENREKIETKIANSKKDISKTNNKILNLDCDKRNIDKEKKMLEENGDLIESKISFIDKTRVLFNDINKYQQSYLNIERLRTEGEQLGDELNDLIKGLETVEDSIGNNQSDYEKIIELNNTITNINNEINIIKENEKAKAELDKLLGSKQELENQINEETSILKNLEIKLDRYDKTKLDLNDKESFISEIKSAVNIGDQCPICGNEIQDLGHHIDFDSIAKRQNEIKEIEANIHAIKSNIAVHNSEIKFVNEKISNINIKTQSDFSLEVLNKRLLENENALNNQRDLNKFIEQMKEEKDNLTLQIHNKQLRLNKNESELKLCRDLITEFETLSKYNNITNFEVDYKKYVQDVNQHQELSKEIEDKLMQLSQRKLIEQNNLNHYENQLETYNNDLELNEQSIEMEMSRLNLTDDNDIDEIIAWRGEQEELEQKRDTYKKRYHEIEMEIARLESLTKDKELLDSDKLKDEYELKKGKMNTLIDEYSAVHYQCQNNINKTQSIVSHINYLNQELKDQQEIFQLAEIVSGKNNKNLTLENFVLIYYLDQIIAQANLRLATMSDNRYQLIRREAVSHGLSGLEIDVFDLHSNKSRHISSLSGGETFQSSLALALGLSEIVQQQSGGISLESIFIDEGFGTLDQETLETALDTLLNLKSTGRMVGIISHVSELKNRIPLVLEVKSDQYQSSTRFKRN
What is the function of this protein?
SbcCD cleaves DNA hairpin structures.  These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions.  The complex acts as a 3'->5' double strand exonuclease that can open hairpins.  It also has a 5' single-strand endonuclease activity (By similarity).
What are the official names of this protein?
Nuclease SbcCD subunit C.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SbcC subfamily.
Protein: PROAL_OLEEU
Sequence: MSWQAYVDDHLMCDIEGHEDHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYKEPVTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-4, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SNL3_ARATH
Sequence: MVGGGSAQKLTTNDALAYLKAVKDKFQDQRGKYDEFLEVMKNFKSQRVDTAGVITRVKELFKGHQELILGFNTFLPKGFEITLQPEDGQPPLKKRVEFEEAISFVNKIKTRFQGDDRVYKSFLDILNMYRRDSKSITEVYQEVAILFRDHSDLLVEFTHFLPDTSATASIPSVKTSVRERGVSLADKKDRIITPHPDHDYGTEHIDQDRERPIKKENKEHMRGTNKENEHRDARDFEPHSKKEQFLNKKQKLHIRGDDPAEISNQSKLSGAVPSSSTYDEKGAMKSYSQDLAIVDRVKEKLNASEYQEFLRCLNLFSKEIISRPELQSLVGNLIGVYPDLMDSFIEFLVQCEKNEGLLSGILTKSKSTYLLQGEGKYPQPSLDNDRDQEHKRDDGLRDRDHEKERLEKAAANLKWAKPISELDLSNCEQCTPSYRLLPKNYPISIASQKTEIGKLVLNDHWVSVTSGSEDYSFSHMRKNQYEESLFKCEDDRFELDMLLESVNSTTKHVEELLTKINSNELKTNSPIRVEDHLTALNLRCIERLYGDHGLDVMDVLKKNVSLALPVILTRLKQKQEEWARCRSDFDKVWAEIYAKNYYKSLDHRSFYFKQQDSKKLSMKALLAEIKEITEKKREDDSLLAFAAGNRLSISPDLEFDYPDHDLHEDLYQLIKYSCAEMCSTEQLDKVMKIWTTFVEQIFGVPSRPQGAEDQEDVVKSMNQNVKSGSSSAGESEGSPHNYASVADSRRSKSSRKANEHSQLGQTSNSERDGAAGRTSDALCETAQHEKMLKNVVTSDEKPESKQAVSIERAHDSTALAVDGLLDQSNGGSSIVHMTGHCNNNLKPVTCGTELELKMNDGNGPKLEVGNKKLLTNGIAVEITSDQEMAGTSKVEREEGELSPNGDFEEDNFAVYAKTDFETFSKANDSTGNNISGDRSREGEPSCLETRAENDAEGDENAARSSEDSRNEYENGDVSGTESGGGEDPEDDLDNNNKGESEGEAECMADAHDAEENGSALPVSARFLLHVKPLVKYVPSAIALHDKDKDSLKNSQVFYGNDSFYVLFRLHRILYERILSAKVNSSSPEGKWRTSNTKNPTDSYARFMTALYNLLDGTSDNAKFEDDCRAIIGTQSYILFTLDKLIHKFIKHLQVVVADEMDNKLLQLYFYEKSRRPETIFDAVYYDNTRVLLPDENIYRIECRLSTPAKLSIQLMCNGLDKPDVTSVSIDPTFAAYLHNDFLSIQPNAREDRRIYLNRNKRKVCREDEQLYSTDEVKIKNGLECKIACGSSKVSYVLETEDLLVRVKKRRKTLCHNQDSWVRQMRLQYYKNNFL
What is the function of this protein?
Acts as a transcriptional repressor.  Interacts with ERF7 to repress genes in abscisic acid and drought stress responses.  The heterodimer represses transcription by tethering SNL3 to DNA.
What are the official names of this protein?
Paired amphipathic helix protein Sin3-like 3, Histone deacetylase complex subunit Sin3, AtSin3, Transcriptional corepressor Sin3.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y948_RHOPA
Sequence: MIQTLTIDQLGHRGDGVSLSQGGATYVPFALPGETVEAEPVQGHPDRRKLLRVEVPSPDRVAPFCPHFGVCGGCAIQHLRDEPYRTWKRNLVIETLAQAGIDVPVDPLIDAHGAGRRRITLHARRGTHDILKVGFSATASHDIIGIDHCPILDPGLNGALEAAWALAEALTPVGKPLDIQVTATENGLDIDVRGSGPLPPKMITSLSQLAEKHKLARLTRHSELVLLRRPPVVAIGKAKVTLPPGAFLQATALGEQTLAELAMAKLGRAKQVADLFCGVGPFALRLAEKARVFACDSDAPAVTALQKAAPATSGLKPVKAEARDLFRRPLAPPELRDFDAVLFDPPRQGAQAQAAQLAASRVPLVIAVSCNATTFARDAKLLIDGGYKLERVIPVDQFKYTPHVELVAVFRK
What are the official names of this protein?
Uncharacterized RNA methyltransferase RPA0948.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: AROA_SALG2
Sequence: MESLTLQPIARVDGAINLPGSKSVSNRALLLAALACGKTVLTNLLDSDDVRHMLNALSALGINYTLSADRTRCDITGNGGPLRAPGALELFLGNAGTAMRPLAAALCLGQNEIVLTGEPRMKERPIGHLVDSLRQGGANIDYLEQENYPPLRLRGGFIGGDIEVDGSVSSQFLTALLMTAPLAPKDTIIRVKGELVSKPYIDITLNLMKTFGVEIANHHYQQFVVKGGQQYHSPGRYLVEGDASSASYFLAAGAIKGGTVKVTGIGRKSMQGDIRFADVLEKMGATITWGDDFIACTRGELHAIDMDMNHIPDAAMTIATTALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPAKLQHADIGTYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARMSTPA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC5A1_SHEEP
Sequence: MDSSTWSPPATATAEPLQAYERIRNAADISVIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIATGGFEWNALILVVLLGWVFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLVLYIFTKISADIFSGAIFINLALGLDLYLAIFILLAITALYTITGGLAAVIYTDTLQTVIMLLGSFILTGFAFHEVGGYSAFVTKYMNAIPTVTSYGNTTVKKECYTPRADSFHIFRDPLKGDLPWPGLIFGLTIISLWYWCTDQVIVQRCLSAKNMSHVKAGCIMCGYMKLLPMFLMVMPGMISRILFTEKVACTVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKIRKKASEKELMIAGRLFMLVLIGVSIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLIIGFLIGVSRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFVITIIVILAISLFTKPIADVHLYRLCWSLRNSKEERIDLDAEDEDIQDAREDALEIDTEASEEKKGCLRQAYDMFCGLDQQKGPKMTKEEEAAMKLKMTDTSEKRLWRMVVNINGIILLAVAVFCHAYFA
What is the function of this protein?
Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1.  Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity).  Has a primary role in the transport of dietary monosaccharides from enterocytes to blood.  Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2.  Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity).  Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity).  Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (By similarity).  Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake.  Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
What are the official names of this protein?
Sodium/glucose cotransporter 1, Na(+)/glucose cotransporter 1, High affinity sodium-glucose cotransporter, Solute carrier family 5 member 1.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: RL14_CHLCV
Sequence: MIQQESQLKVADNTGAKKVKCFKVLGGSRRRYATVGDIIVCSVRDVEPDSSIKKGDVVKAVIVRTRRDILRKDGSSLRFDTNSCVIIDEKGNPKGTRIFGPIAREIRDRGFVKISSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: VIRK_HYPVG
Sequence: MPSYVITGASRGLGFEFVRQLSSDPNNTVIGLVRDKVTTEQAVAQELAGRSNIHILQADITDYEAVKDAVTATAQITGGVLDYLVANAAYISEFDAYDSIGVLGNSPKELEEDLFKSFKVNVIANVHLFNLYMPLILAGNIKKVIALSTGMADLDSTNKFELQVAPGYAISKAAMNTAIGKFHAQYKKDGVLFMSISPGVVDTGHYKNATPEQMAKVGGMFQNFVTYNPDFKGPASPEASVKDVISVWENASIEAGSGGSFVSHHGNKKWL
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of virensols and trichoxide, fungal natural products that contain or are derived from a salicylaldehyde core (PubMed:31790246).  The pathway begins with the synthesis of the reduced chain in virensol C by the highly reducing polyketide synthase virA via condensation of one acetate and 8 malonate units (PubMed:31790246).  VirA has interesting programming rules since the first 2 ketides are fully reduced, the 3 following ketides undergo beta-dehydration, and the last 3 ketides are only reduced to beta-hydroxys to yield the trihydroxy portion (PubMed:31790246).  The production of aldehyde virensol C by virA alone is surprising, since virA does not contain a reductase (R) domain that is typically associated with reductive product release in HRPKS (PubMed:31790246).  The cupin-domain enzyme virC is involved in enhancing virA product turnover (PubMed:31790246).  The short-chain dehydrogenase virB then oxidizes the C-7 alcohol of virensol C to a ketone, yielding virensol D (PubMed:31790246).  Virensol D is further transformed to salicylaldehyde 5-deoxyaurocitrin by the short-chain dehydrogenase virD (PubMed:31790246).  VirD catalyzes the dehydrogenation of C-3 to form the beta-ketone aldehyde, which is followed by the generation of the nucleophilic C-2 that is required for the intramolecular aldol condensation between C-2 and C-7, itself followed by dehydration and aromatization which leads to salicylaldehyde 5-deoxyaurocitrin (PubMed:31790246).  While the dehydrogenation of virensol D is definitely catalyzed by virD, the aldol condensation and dehydration may be uncatalyzed or assisted by virD (PubMed:31790246).  The short chain dehydrogenase virG then converts salicylaldehyde 5-deoxyaurocitrin into virensol B which is further hydroxylated by the cytochrome P450 monooxygenase virE to yield the hydroquinone virensol A (PubMed:31790246).  VirI then may oxidize virensol A to form the quinone, while virH performs the epoxidation (PubMed:31790246).  Finally, the two remaining short-chain dehydrogenases, virK and virL, are probably responsible for reducing the ketones to the corresponding alcohols to furnish the epoxycyclohexanol structure in trichoxide (PubMed:31790246).
What are the official names of this protein?
Short chain dehydrogenase virK, Trichoxide biosynthesis protein virK, Virensol biosynthesis cluster protein K.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.