PharMolix/UniProtQA huggingface dataset:
Protein: BMP7_MOUSE
Sequence: MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEESGPDGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFQITVYQVLQEHSGRESDLFLLDSRTIWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHLRSIRSTGGKQRSQNRSKTPKNQEALRMASVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPDTVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
What is the function of this protein?
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:9013703, PubMed:22461901).  Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A.  Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1.  In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.  For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor.  Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (By similarity).
What are the official names of this protein?
Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL3_BURVG
Sequence: MMSLGLVGRKVGMTRIFTAEGDSIPVTVLDVSDNRVTQIKTVETDGYTAVQVAFGSRRASRVTKPLAGHLAKAGVEAGEILKEFRIDAAKAAELSNGAVVGADLFEVGQKVDVQGVSIGKGYAGTIKRYNFSSGRATHGNSRSHNVPGSIGMAQDPGRVFPGKRMTGHLGDVTVTVQNLEIARIDAERKLLLVKGAIPGAKGGKVFVTPAVKTKGAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: I23O1_RAT
Sequence: MPHSQISPAEGSRRILEEYHIDEDVGFALPHPLEELPDTYRPWILVARNLPKLIENGKLREEVEKLPTLRTEELRGHRLQRLAHLALGYITMAYVWNRGDDDIRKVLPRNLAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLMVEIAASPAIKAIPTVSSAVEHQDPKALEKALCSIAASLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKGNPKLPEGLLYEGVWDTPKKFSGGSAGQSSIFQSLDVLLGIKHDVGEGSAAEFLQEMREYMPPAHRNFLSSLESAPPVREFVILRRNEDLKEAYNECVNGLVSLRMFHLSIVDTYIVKPSKQKPMGGHKSEEPSNTENRGTGGTDVMNFLRSVKDTTKKALLSWP
What is the function of this protein?
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway.  Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses.  Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells.  Acts as a suppressor of anti-tumor immunity.  Limits the growth of intracellular pathogens by depriving tryptophan.  Protects the fetus from maternal immune rejection.
What are the official names of this protein?
Indoleamine 2,3-dioxygenase 1, IDO-1, Indoleamine-pyrrole 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the indoleamine 2,3-dioxygenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TDH_SHEWM
Sequence: MKALSKLKPEEGIWMVDAPKPEMGHNDLLIKIRKTAICGTDVHIYNWDEWSQNTIPVPMVVGHEYVGEVVDIGQEVRGFSIGDRVSGEGHITCGHCRNCRAGRTHLCRNTSGVGVNRDGAFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELAQKMGATRAVNVAKEDLKDVMSELGMTEGFDVGLEMSGVPSAFHSMLDTMNHGGKVAMLGIPGGDMAIDWSKVIFKGLIIKGIYGREMFETWYKMASLIQSGLDISPIITHHYKVDEFQQGFDAMRSGQSGKVILNWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_CERS1
Sequence: MAVGVFDSGLGGLTVLDAVQRRLPEVPFVYFGDNAHAPYGVRDADDIFHLTCAATERLWAEGCDLVILACNTASAAALKRMQETWIPKDKRVLGVFVPLIEALTERQWGDNSPPREVAVKHVALFATPATVASRAFQRELAFRAIGVDVEAQPCGGVVDAIEQGDEILAEALVRSHVEALKRRMPHPQAAILGCTHYPLMEPIFQEALGPEVSVYSQANLVAESLADYLARKPEFAGAGTESKFLTTGEPRSVSNKATQFLRRRITFEAA
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: VP30_BPPRD
Sequence: MALINPQFPYAGPVPIPGPAPTETMPLLNYRVEGRIAGIQQARQFMPFLQGPHRAVAEQTYHAIGTGIQMGQTFNQPLINTQEG
What is the function of this protein?
Minor capsid protein essential for stable capsid assembly of complete particles.
What are the official names of this protein?
Minor capsid protein P30, Protein P, GpP.
What are the subcellular locations of this protein?
Virion. Note=The capsid contains 60 copies of P30.
Protein: QUEA_RICCN
Sequence: MKLSDFDFDLPSELIAQYPSSERDNSDLLIAVTPPIKTKFYNIIDYLKEGDLLVFNNSKVIKAKLNLGKNITINLNQKLSDDNWSAFAKPARKLHVNDEFYFDNHKVIITEKLAMGEIKVKFELNDISVFEFLNKYGEMPLPVYIRRSHSLCHPVATTTGSKTYLNNDWIPWSNHGMTNTQNDNDRYQTVYSQIEGSVAAPTAGLHFTKDILDKLKAEGIQATFLTLHVGAGTFLPVKTENIHEHKMHTEYCSITPDTAEIINKAKQEGKRIIAVGTTTLRTLESSCNNGIVKAGSFKTDIFITPGFKFQTADMLLTNFHFPKSTLFMLICAFAGFKEMHELYKYAIKEAMRFFSYGDATLLCRK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S20AA_DANRE
Sequence: MESTTLASLAAVSVLAAGAQTDMSDVLWLLILGFVIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILATIFETVGAMLLGAKVSETIRSGIIDVHMYNGSEAVLMAGSISAMFGSAVWQLAASFLKLPISGTHCIVGATIGFSMVARGHQGVKWLELLRIVASWFLSPLLSGIMSAVLFYFVRKFILNKDDPVPNGLRALPVFYAVTMGINLFSIMFTGAPMLGFDRIPWWGTLLISLGCAILTALVVWFIVCPRLKKKMQSKCLGPNIADTSGTQLVEKKPSSNGLMDHHPGPPRNYSPVPQTPPADSNKVAFDIGGSAETDLDKKEFDTKDQDCTHALNGSGGIVIPDLSGNQFHTVHKDSGIYKDLLHKLHLAKVGECIGEPVEKPIRRNNSYTSYTMAIYGIHGSLKDGEGGSRTGLDGEKRRSRYDSYNSYCTAVADGEAALEDAALAVGMEDEALREDVLEEDIDELEIDKPEVSTLFQFLQILTACFGSFAHGGNDVSNAIGPLVALWLIYDSASVAPSAPTPIWLLLYGGVGICTGLWIWGRRVIQTMGKDLTPITPSSGFSIELASAITVVVASNIGLPVSTTHCKVGSVVSVGWLRSRKAVDWHLFRNIFIAWFVTVPISGLISAAIMALFYYVILPLT
What is the function of this protein?
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.
What are the official names of this protein?
Sodium-dependent phosphate transporter 1-A, Solute carrier family 20 member 1-A.
What is the protein family that this protein belongs to?
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HIS3_RHOBA
Sequence: MSSHVPNFDAGVPCPKTGQPLLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVVREIRVDCDADTILLSVEQTGAACHENYESCFFRRVDPDGTTHITEERIA
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YE38_SCHPO
Sequence: MNEQDLLNSLRRDLNLPNLGKSHDGSEAVESTFPEKKESSLSAQQPHVDDQRSSLLSLLNAGLNASNQSPSNSGPKYYASHSSSTDALLQAFRDGAKPSGTASGADVKRSDSESTEATSNERPFNPVSAANLERLLMSSTGPQTPINGELKSNDSQDTAFQSSRNMPSDTSVASPDYSHSQSSSPIANYQESGNSEEPHKAEEQQQLSIYQLDNPGSGNYVWETVISPDKFETSTFAKCERNDIAIINRELDAQDNQLIHTNEDFIAYAVHREPIIRVIEISTGKSFLLHNNSPNKFVSVAWGNDSVIKNRLMAIDTTGQVLIFAVDIATSTSEIIFQLSGAQSLSDPIKSRFHWYPKSSTRFAVALSKHIIFFDLDLLNNISFPIPRSINAIQQLPCFLIDTGISAKEYDFSYDGTVFATVDKDALIKIYTVPTTFPSTPDKRPVPSEVSPIAIFTTRMERGPSKNYEKPINLRFISTPGTNNSRYLVIVYVMNQLITLFDLYSKRNIQTFRFNNRPTAATTTSFSQFSVDNERSTLLVGNPPSNSIYFFLFAKDETVSEQAPIYNSTYELILASLNTSEPVPADAKFSVIVAKKFEKAACISFTACKILESEDKYCIVVSNTDGYEYYSIPTSILDKTGKTVRSLESVQNYDADIGGTIDLTERHSTASPSTVNSGFSTPRSQATGFSKKKKDKGERFETKDKSSSVLSPSSYSASTFDAIPMDSIVSNILASLEKSVHKNYESLRSQLLEYKAANEKHTEAILSVVSSTLTENTGKILESVVEKSMQVALKEEIANSVRNALKNNLEKIESFLENSIAELQNSVREDFDKQTSSLAQLRYSIQNVAHAQKESEVKYNELNEQVKTLEGYVETVLEKFNDLKIENKVPETAPDVVPSSYPPAAESNVSVSSDTSTKDVEKQEPSSAEQPAQGIAESLRRLKEYVKAGSVKECVAEWCNMPSVAGFDVLSEISYDRMLENCSNLLLLTFIYHISLLDSVDDDRLSKRMEYISRICLNIDVNDPKVETVVHPVLTLTREALLRQSEFFSPIFKRRLVVLLRALDGKISEISVASSN
What are the official names of this protein?
Uncharacterized protein C20G4.08.
Protein: GUF1_PICGU
Sequence: MYIHSSRTVLARYGSRTPLLRPSVLGRYSTSPAATIEARKIALNRDNYIKSVYDRIAKIPPENYRNFSIVAHVDHGKSTLSDRLLELTGVIQPGDKNQVLDRLDVERERGITVKAQTCTMIFNDPRNGQDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDATQGVQAQTVANFYLAYSMGLKLIPIINKIDLDAADIPRAMDQVESTFELDRENCLQVSAKTGLNVKSILPAIVDHIPAPDCDINSPLKALLVDSWHDPYVGVVMLLYVKEGTIKKGMKLLSAHTEGRYEVKEVGIMYPDKVPMESIRAGQVGYIVPGMKDPSQAKIGDTFFQYGKHEGLEALPGFEEPKPMVFVGAFPAEGSEFKVMDDHIANLVLNDRSVTLEKETSNALGLGWRLGFLGSLHASVFQERLENEYGAKIILTAPTVPYKIVYKDGTDKIVTNPDEFPGSDLRNQNVDKLMEPYVNAIMTIPDEYIGAVMSLCENNRGIQKELEYLTNGQVLMRYEIPLAQLVEDFFGKLKGCTKGYASLDYEDAGYKKSDIVKMELCVNGEPQDALTQVMHRSQVQARGKEYVVRFKEYLRFQLFEVAIQAKVNNKVVARETIKAKRKDVTQKLHAADISRRKKLLSRQKEGKKQMKASGRVHINHEAYQAFLRRTI
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: DPO4_NITMS
Sequence: METRIVFHIDFDYFYAQCEEIRSPELKSKPVCVCVFSDRGGDSGAIATANYTARKYGAKSGIPIVFAKKRLEERKDAVFLPVDFDYYSEMSEKAMKIMEEFSDVFEYVGRDEAYLDVTKRTEGDFHKASHLAQQIKNSIREKTKLSCSIGISPNKLISKIASDFQKPDGLTIVSPEKVEGFLESLKIRDIPGIGKKTEQRFTEMNLETIGDVKRLDVFTLNKEFGRKSGTYIYNAVRGIDDELVKEREPSIQHGKIVTLKKDSKDYEFLLENTLELCKEVHEIIQKKNQMFKSVGISFVQSDLSNKTKSKMLRNPTMSLEELEKTVEQLLREALENQTATIRRLGVKVSELSESQGQRDITSYF
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSP2_YEAST
Sequence: MSAPAQNNAEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVDEQLMHQYQQEMDQATALPLPDEDDADL
What is the function of this protein?
GTP-binding protein involved in nucleocytoplasmic transport.  Required for the import of protein into the nucleus and also for RNA export.  Not essential for cell viability.
What are the official names of this protein?
GTP-binding nuclear protein GSP2/CNR2.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SM16_SCHMA
Sequence: MSEEKQWTEVFHAIDKDKNGFLTREEIAQCLKEVGVCPNVADKIIKETDMNSDGKISLEEYLNALRKLPPREKCVARWREVFQSIDKDGSGKVSIKELDEFLKTSGMDIDQNSLRNWMTQNDKNKDGELDYDEFLAYVRQTYK
What is the function of this protein?
Calcium-binding protein.
What are the official names of this protein?
16 kDa calcium-binding protein, Egg antigen SME16.
Protein: BIOD_NEIMF
Sequence: MKGVYFVSGIDTDIGKTVATGMLAKQLLQQGKSVITQKPVQTGCQDIAEDIAVHRKIMGIPMQEADKRRLTMPEIFSYPASPHLAARLDGRALDLDKIRTATQELAAQYEIVLVEGAGGLMVPLTEKLLTIDYIQQQAYPVILVTSGRLGSINHTLLSFAALKQYGIRLHSLVFNHIHDSRDAHIAQYSLSYLKCRLKADFSEAEWMELAKTDAV
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHF2_PONAB
Sequence: MAMPTVFSTSSRMLALSRHSLLSPLLSVTSFRCFYRGDSPADSQKDLIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEVFENEVMALLRDFAKNKNKEQRLRAPDLEYLFEKPR
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 2, mitochondrial, SDH assembly factor 2, SDHAF2.
What is the protein family that this protein belongs to?
Belongs to the SDHAF2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: EPHA3_RAT
Sequence: MDCHLSILILFGCCVLSCSRELSPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFLEHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCTCNAGYEERGFICQACRPGFYKALDGVAKCTKCPPHSSTQEDGSMNCRCENNYFRAEKDPPSMACTRPPSAPRNVISNINETSVILDWSWPLDTGGRKDITFNIICKKCGWNVRQCEPCSPNVRFLPRQLGLTNTTVTVTDLLAHTNYTFEIDAINGVSELSSPPRQFAAVSITTNQAAPSPVMTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTTYVFQIRARTAAGYGTNSRKFEFENSPDSFSISGENSHVVMIAISAAVAIIVLTVVTYVLVGRFCGYHKSKHSSDEKRLHFGNGHLRLPGLRTYVDPHTYEDPTQAVHEFAKELDATNIAIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPVRWTSPEATAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPLPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDIATFHTTGDWLNGMRTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGPVPV
What is the function of this protein?
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5.  Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration.  Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1.  Involved in the retinotectal mapping of neurons.  May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development (By similarity).
What are the official names of this protein?
Ephrin type-A receptor 3, EPH-like kinase 4, EK4, rEK4, Tyrosine-protein kinase TYRO4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: BRXC_BACSU
Sequence: MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAFANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAAIEQHLS
What is the function of this protein?
S-bacillithiolation is the formation of mixed disulfide bonds between protein thiols and the general thiol reductant bacillithiol (BSH) under oxidative stress.  BSH is an equivalent of glutathione (GSH) in Firmicutes.  This protein is a monothiol bacilliredoxin, which debacillithiolates (removes BSH) the S-bacillithiolated glyceraldehyde-3-phosphate dehydrogenases (GAPDHs) GapA and GapB in vivo and probably a number of other oxidized cytosolic proteins.  Debacillithiolates the S-bacillithiolated Bdr (Bdr-SSB) and BrxB (BrxB-SSB) in vitro.  Involved in maintaining redox homeostasis in response to disulfide stress conditions.
What are the official names of this protein?
Monothiol bacilliredoxin BrxC, Monothiol Brx-C, Bacillithiol system redox-active protein YtxJ, ORF2, ORF3.
Protein: LSM1_YEAST
Sequence: MSANSKDRNQSNQDAKRQQQNFPKKISEGEADLYLDQYNFTTTAAIVSSVDRKIFVLLRDGRMLFGVLRTFDQYANLILQDCVERIYFSEENKYAEEDRGIFMIRGENVVMLGEVDIDKEDQPLEAMERIPFKEAWLTKQKNDEKRFKEETHKGKKMARHGIVYDFHKSDMY
What is the function of this protein?
Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step.  The LSM1-LSM7 complex binds RNA with a preference for poly-U ends.
What are the official names of this protein?
Sm-like protein LSm1, SPB8 protein.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, P-body.
Protein: RL4_PROMH
Sequence: MELVMKDAQGALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVSGSGKKPWRQKGTGRARSGSIKSPIWRSGGVSFAAKPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIVTAEVDENLYLAARNLYKVDVRDAATIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: Y1620_HAEIN
Sequence: MKIHHLFQPHFRLIYLFIWGLIISGLSDLTWLIPLNVLAVSLFFISLQFSQKSFLPYLKRWFALVIFIVLMWATLSWKIGENGIELNFQGIELAEKLSLRTHLLLISLWLFLWNINDAVLVPSHWQIAFARKINSTFCADRTLHCTAWRIASKNGYCHARSWISSSA
What are the official names of this protein?
Uncharacterized protein HI_1620.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HUT1_DEBHA
Sequence: MKKEGGGSIITLAACILGLYASFLTWSVLQERISTKPYGSNPDTGSPDFFKAPLVINIIQAFFASIVGLIYSVVSSRSNPLSIFTQNEKPVALKFFKSFVIISLTSSLSSPLGYESLKHVDYLAYLLAKSCKLIPVMLVHFVLYRTKFPLYKCMVAGSVTVGVIIFTLSHSSTKSKADISDGKTALGMAQLIGSMLLDGLTNSTQDQLFKLRGTSPSNKHTKLTGAYLMCILNAFIFINTLAYALIFKYQSEITYTVNFVHHYPQVMMNILEFAILGSVGQVFVFIILEKFDSLILITSTVTRKMISMILSVVLFGHQLNGLQWGGVGLVFGGIGYEALVKMSMNKAPTTKKNQ
What is the function of this protein?
May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen.  Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity).
What are the official names of this protein?
UDP-galactose transporter homolog 1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LYTS_STAAW
Sequence: MLSLTMLLLERVGLIIILAYVLMNIPYFKNLMNRRRTWKARWQLCIIFSLFALMSNLTGIVIDHQHSLSGSVYFRLDDDVSLANTRVLTIGVAGLVGGPFVGLFVGVISGIFRVYMGGADAQVYLISSIFIGIIAGYFGLQAQRRKRYPSIAKSAMIGIVMEMIQMLSILTFSHDKAYAVDLISLIALPMIIVNSVGTAIFMSIIISTLKQEEQMKAVQTHDVLQLMNQTLPYFKEGLNRESAQQIAMIIKNLMKVSAVAITSKNEILSHVGAGSDHHIPTNEILTSLSKDVLKSGKLKEVHTKEEIGCSHPNCPLRAAIVIPLEMHGSIVGTLKMYFTNPNDLTFVERQLAEGLANIFSSQIELGEAETQSKLLKDAEIKSLQAQVSPHFFFNSINTISALVRINSEKARELLLELSYFFRANLQGSKQHTITLDKELSQVRAYLSLEQARYPGRFNININVEDKYRDVLVPPFLIQILVENAIKHAFTNRKQGNDIDVSVIKETATHVRIIVQDNGQGISKDKMHLLGETSVESESGTGSALENLNLRLKGLFGKSAALQFESTSSGTTFWCVLPYERQEEE
What is the function of this protein?
Member of the two-component regulatory system LytR/LytS that regulates genes involved in autolysis, programmed cell death, biofilm formation and cell wall metabolism.  Participates also in sensing and responding to host defense cationic antimicrobial peptides (HDPs).  Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of LytR.  In turn, LytR binds to the upstream promoter regions of target genes including lrgA and lrgB, to positively regulate their expression.  Possesses also a phosphatase activity that dephosphorylates and thus inactivates LytR.
What are the official names of this protein?
Sensor histidine kinase/phosphatase LytS, Autolysin sensor kinase.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NADA_NOCSJ
Sequence: MTIADLPLLPLGRGTDLTSERGVECPGDLPPASDPALVERARAAKAALGDRVFVLGHHYQRDEVIQFADVTGDSFKLAREAAARPDAEYIVFCGVHFMAESADILTGPSQQVILPDLAAGCSMADMARLTQVEMAWDALAAAGVADSVVPVTYMNSSADIKAFCGRNGGLVCTSSNAEVALEWAFEQKGGVEGDAKILFLPDQHLGRNTAVLKMGLSVDDCVVWDPFRPGGGLTPEQLRAAKVILWRGHCSVHGKFSPDVVDELRATIPGVQILVHPECTHELVLKADLVGSTEFIIKTIEAAPSGSSWSIGTELNLVKRLSAAHPDKNISFLDKTVCYCSTMNRIDLPHLVWALESLVAGTVVNRIEVDPETETWALLALERMLALPGKSHKD
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTCB_CAEEL
Sequence: MPRTFEEECDFIDRLTDTKFRIKKGFVPNMNVEGRFYVNNSLEQLMFDELKFSCDGQGIGGFLPAVRQIANVASLPGIVGHSIGLPDIHSGYGFSIGNIAAFDVGNPESVISPGGVGFDINCGVRLLRTNLFEENVKPLKEQLTQSLFDHIPVGVGSRGAIPMLASDLVECLEMGMDWTLREGYSWAEDKEHCEEYGRMLQADASKVSLRAKKRGLPQLGTLGAGNHYAEVQVVDEIYDKHAASTMGIDEEGQVVVMLHCGSRGLGHQVATDSLVEMEKAMARDGIVVNDKQLACARINSVEGKNYFSGMAAAANFAWVNRSCITFCVRNAFQKTFGMSADDMDMQVIYDVSHNVAKMEEHMVDGRPRQLCVHRKGATRAFPAHHPLIPVDYQLIGQPVLIGGSMGTCSYVLTGTEQGLVETFGTTCHGAGRALSRAKSRRTITWDSVIDDLKKKEISIRIASPKLIMEEAPESYKNVTDVVDTCDAAGISKKAVKLRPIAVIKG
What is the function of this protein?
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs (PubMed:25366321).  Required for the ligation of mRNAs and specifically, regulates xbp-1 mRNA splicing during the endoplasmic reticulum stress-induced unfolded protein response (PubMed:25366321, PubMed:25429148).  Has a neuroprotective role in the age-dependent degeneration of dopamine neurons, which is mediated by xbp-1 (PubMed:25429148).
What are the official names of this protein?
RNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.