PharMolix/UniProtQA huggingface dataset:
Protein: TRMA_ECOSM
Sequence: MTPEHLPTEQYEAQLAEKVVRLQSMMAPFSDLVPEVFRSPVSHYRMRAEFRIWHDGDDLYHIIFDQQTKSRIRVDSFPAASELINQLMTAMIAGVRNNPVLRHKLFQIDYLTTLSNQAVVSLLYHKKLDDEWRQEAEALRDALRAQNLNVHLIGRATKTKIELDQDYIDERLPVAGKEMIYRQVENSFTQPNAAMNIQMLEWALDVTKGSKGDLLELYCGNGNFSLALARNFDRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKSYQCETIFVDPPRSGLDGETEKMVQAYPRILYISCNPETLCKNLETLSQTHKVERLALFDQFPYTHHMECGVLLTAK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: MURC_ACTSZ
Sequence: MKKRQDKIRQMVPSMRRVHQIHFVGIGGAGMGGIAEVLLNEGYDITGSDIAENAVTGRLSSLGGKIFIGHAATNVENASVVVVSSAIKPDNVEVVAAHEKRIPVIQRAQMLAELMRFRHGIAIAGTHGKTTTTAMISMIYTQAGLDPTFVNGGLVKSAGTNAYLGASRYLIAEADESDASFLHLQPMVSVVTNIEPDHMDTYHGDFDEMKRTYVNFLHNLPFYGLAVMCADDAVLMELVPQVGRQVITYGFSEKADYRIENYEQTGFQGHYDVITPAGERIHILLNVPGKHNALNATAALVVAKEEGIGNDAILAALADFQGAGRRFDQLGEFIRPNGKVMLVDDYGHHPTEVGVTIQAARSGWENRRVVMVFQPHRYSRTRDLFDDFVRVLSQVDVLILLDVYPAGEQPIAGADSRSLARSIRNLGKVDPIFVADHGQLPEVVDQIIQDGDLILAQGAGNVSRLSRNLVEHWTKA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U512W_DICDI
Sequence: MTIFNSISSISNPTRTALSSINTYNYNGSSVNDNSTAYFDNDFGGWGGLGNFCNGNGCGGGSSNVNVINLDIDIGSRRHRRCC
What are the official names of this protein?
UPF0512 protein W.
What is the protein family that this protein belongs to?
Belongs to the UPF0512 family.
Protein: CYB_CANAL
Sequence: MPTRKSNTYLSLVNSYLIDSPQPSSINYWWNLGSLLGLCLVIQIASGVFLAMHYSSNIELAFDSVEHIMRDVNAGWLIRYIHANGASFFFICMYLHIGKALYYGSYKQPRVMLWVIGVVIFILTMAIAFMGYCLVYGQMSHWGATVITNLLSAIPFIGNDIVPFIWGGFSVSNPTIQRFFALHFLLPFILAALVCMHLMALHVHGSSNPVGITGNIDRLPMHPYFIFKDLITVFVFLLIFSLFVFYSPNTLGHPDNYIPGNPMVTPPSIVPEWYLLPFYAILRSIPDKLGGVIAMFGAILILLSLPYTDRSIIRGNSFKVLSKLAFYLFVFNFILLGNLGQLHVEVPYIQLGQFATAYYFAHYIIVVPVISTLENILYYIGTQTRVK
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: IL15_MARMO
Sequence: MRISKPHLRITSIQCYVCLLLNTHFLTEAGIRVFILGCISAGIPKTEANWEDVRKDLQKIENLIQSLHMDATLYTESDVHPRCKVTAMNCFLLELEVISHESRDGDIEETVKNLILLANSSLSSNGNITESGCKVCEELEEKNITEFLESFKHIVQMFINPP
What is the function of this protein?
Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems.  Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines.  In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection.  Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits.  Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity).  In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
What are the official names of this protein?
Interleukin-15, IL-15.
What is the protein family that this protein belongs to?
Belongs to the IL-15/IL-21 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NOP10_METTH
Sequence: MKMKRCRSCGEYTLKEVCPHCGGRTGVIYPPKFSPEDKYGAYRRKLKRELYSRGSGESK
What is the function of this protein?
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
What are the official names of this protein?
Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
Protein: APC4_SCHPO
Sequence: MVSKSFKYPKKHKFEWINETNRVERVGSGLKRVILCPSMELIAILTCSNHLICCRSNSQRIWDVDFHDLEATELCWNHDGNLIVVGFKNGELKIIDSSTGHLVEQRPASRDLAVLMITWAMQETIVNEKRNDFLFDATAYMPLLGTLPSSAKEERIFSSKAIAQFFEPRKREGENNKKVELLSILDERGIRYINMFSSYKIGESDSLKSALNLGVPISHSITNDLAYHVLICKGGTNISLKTLYMPLLKNDLGSIVDIATMSTRMQHLVRYLEEVLNAMYEEFDNVFKSEASFIKTFDALVSKYSDTTFFSLQLELYQFIMNGIPSDLLKEWINERVGDRVLKNWERAMVNSYTSLIIFCQEFVIPACERLTVLLSSARGKSIWGHMKGNTLLDAKLVEDCLATLGYLQNNVFSFLNCLFEEKKYMKHFISWLNYAIVEFNTSEPSSIPPQEIIEHINETVIYIRHSLFRSKLTSYFMGTKPLQLRDPDYYSLKDFANQDDSNSVDDFVSFKTLKESLRDSFNVIFSYPSLTCQKQWLKTGDLVLFEGTDWNVSSLIPKSCNEKNQLFSLFFRKDTPNIFLIISQLMENTMLPVSGCHFGLDYAELLGSSLLDFQPATVLDMKLLNGSSILILGKLKEKCFLCEICLADVPLTFFEHQQKNSYLDAISHLPFIPLNSCLWLHEFEKDFLPSTLEYALSENSDYGVLISRESSRYRLFSF
What is the function of this protein?
Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.  Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.
What are the official names of this protein?
Anaphase-promoting complex subunit 4, 20S cyclosome/APC complex protein apc4, Cell untimely torn protein 20.
Protein: MAO1_SODGM
Sequence: MELEYESKRPLYIPHAGPILLEFPLLNKGSAFSLEERDNFNLQGLLPDTVETIEEQAERAWRQYQDFRTNIDRHIYLRNIQDTNETLFYRLLAAHLAEMLPIIYTPTVGDACERFSDIYRRARGVFISYNNCDKIEDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDAGTNNQQLLNDPLYMGWRHPRITGEQYDKFVDAFIQAVKRRWPNVLLQFEDFAQKNATPLLNRYRSELCCFNDDIQGTAAVTLGCLLAASRAAGKRLRDQKVVFLGAGSAGCGIAEQITAEMRTEGLSEDEARRRVLMVDRFGLLTDKLANLLDFQSRLVQPSDSLSDWQLDSDTISLQDVVRNARPTVLIGVSGQPGLFTEEIIRDMHQHCERPIVMPLSNPTSRVEATPEDLLRWTDGAALVATGSPFAPVQFEGKTYPIAQCNNAYIFPGIGLGVLASGAGQITDAMLIAASRALADCSPLANGDGGALLPDINDIQSVSRVIAMAVAKAAQVHGVALVTSEETLSLAIEHNFWQPQYRDYRRTSF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: RK185_ORYSJ
Sequence: MGCFPCFGSGGKGEAKKGGGGRKDGGSADRRVARVGSDKSKSQGGLDSRKDAFIPRDANGQPIAAHTFTFRELAAATKNFRQDCLLGEGGFGRVYKGHLENGQAVAVKQLDRNGLQGNREFLVEVLMLSLLHHDNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDIPPDKEPLDWNTRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLGEGYHPKLSDFGLAKLGPVGDKTHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRKAIDNTKPLGEQNLVAWARPLFKDRRKFPKMADPLLAGRFPMRGLYQALAVAAMCLQEQAATRPFIGDVVTALSYLASQTYDPNTPVQHSRSNASTPRARNRVGANFDQRRLHSPNHQQSPDLRKEGTTTSKYEAEVSRTNSGSGSGRRAGLDSMDVTGSQMGSPAHAGRKRESSRSTDRQRAVAEAKTWGENSRERKWPNARGSFDSTNE
What is the function of this protein?
Functions as an immediate downstream signaling partner of CERK1 in the microbial peptidoglycans (PGNs) and fungal chitin signaling pathways that mediate innate immunity.  Is required for chitin-induced activation of MPK3 and MPK6.  Participates in the activation of defense genes during response to PGN and chitin.
What are the official names of this protein?
Receptor-like cytoplasmic kinase 185, OsRLCK185.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ATPE_STREI
Sequence: MTFMTVQVVTPDGIRYDHHANFISVKTPDGEMGILPEHINLIAPLTVHEMKIHRTDDPNHVDWVAINGGIIEIKDNLVTIVADSAERERDIDVSRAERAKIRAERKLEQAQSTHDIDEVRRAQVALRRALNRISVGNK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HIS7_BACCR
Sequence: MRQSSQARETTETKIKLNLQLDESTNVSIQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKEALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYCVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARVLYGSNTHHKIEALFKAFGRALREAVEKNANITGVNSTKGML
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_RUTMC
Sequence: MKTAQIRQKFLDYFESKGHTIESSASLIPHNDKTLLFVNAGMVLFKDVFSGVEKRPYMRAVSVQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKREAIYYAWEFLTKELNLPKEKLWVSVFEEDDEAENIWINEIGFPKNRISRCGTKDNFWQMGDTGPCGPSSEIFYDYGEHIAGGPPGHADEDGDRYIEIWNLVFTQFDKQEDGHLKPLAVPCVDTGMGLERLAAVLQHKNNNYDTDGFQSLVKAIVNLTPKSNNIKNNNASVRVIADHIRSTAFMIVDGVNPSNEGRGYVLRRIIRRGIRHGHKMGIDKVFFYRLAPVLALEFKDAYPELKQALPKVEKVLKREEQRFSQTLDQGMRLLEDAITNLNGSEIDGKTVFKLYDTYGFPIDLTADIARERHLTIDMLGFEFEMTRQRDRARQAGDFKISKKNVDIIGVTEFLGYEQLENISSILALVKNSKLVEEIKAGEYGIVVLAQSSFYAESGGQVGDSGVLSNAKIEFKVDHTNKQKSGVFEHYGVLNKGVLKVGDTIQANVDKKSRKCIARNHSATHLLHAALRIVLGETVTQKGSLVDSEKLRFDFSHDEVITKSDINKIEGMINRKILGNTKVHTDIINIENAKKKDAIALFGEKYSDTVRVLTMGKDDFSVELCGGTHVKQLGDIGLFRITSESGVSAGVRRIEALTGYDAYQFDNQMQNSLSEISQMTKSNNAQVVEKVTQFIKQQKELEEQITIFQKQLTSNQGDDLIGQVQEVRNIKLLSTVVEGSSGKDLRNIADKLKDKLGSAVIVLAVVSNDKVSLVVGVTKDLTKRYQAVKILNYVAEQIGGKGGGRPDMAQGGGTQPEYLAKALASVKSLI
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_MARMS
Sequence: MKVGVMDSGAGGLTILNAIHQKHPYLDLVYLADDAFAPYGSKSITQLQDRLVKVGRFFENEKVCAIVVACNTATVAAIDALRASTSLPIIGVEPAVKPAFRLSKKRRVAVLATPVTAESPRLNQLIDLWKEDSHVSIMSSLTLAFDIDAWPETEEKVKQTIEQLSQEMLAQNIDTLVLACTHYPLVKHLFEQILGDECEIIEPSEGVTAQLIRRLTESYPNDMSQLLDAVSTRQDSSQNQGSIELCSSLGFKNMQRLNSWVVSSSAIKGCRHVLI
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: OTC_NEIFV
Sequence: DQGAGVTYLEPSASQIGHKESIKDTARVLGRMYDGIEYRGFGQDVVEELAKYAGVPVFNGLTNEFHPTQMFADALTMREHSGKPLNQTAFAYVGDARYNMANSLLVLGAKLGMDVRIGAPKTLWPSENIVARARAVAEETGGKILLTENAEEAVKGADFIHTDVWVSMGEPKEAWQERIDLLKDYRVTPELMAASGNPQVKFMHCLPAFHNRETKVGEWIYETFGLNGVEVT
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAXC_CHLT2
Sequence: MLLKKRSPTSILGTLALTGIVISYMIGGGIFSLPQNMAASASAGAVMLAWMLSGIGIFFIANTFKTLSIIRPDLKAGIYTYSREGFGPYVGFTIAWGYWLCQIFGNVGYAVITMDALNYFFPPYFAGGNTIPAILLGSLLIWIFNYIVLRGIRQASFVNIIGVVCTLIPLLLFILITARFFKFSIFKTDFWGTAPQHTLGSIGSQLKSTMLVTLWAFIGIEGAVVISGRAANPSSVGKATILGFSGCLLIYVLLSLLPFGSLFQYQLAKIADPSTAGVLNILVGKWGEVLMNTGLLIAVLTSWLSWTILASEIPYAAAKNGTFPECFAIENSKHAPSFSLFMTSGLMQITMLLVYFSSNAWNTMLEITGVMVLPAYLTSSLFLVKFSLSKKYPKQAAIKARIAMITGLLGSLYSLWLIYAGGLQHLFMVAILLALGIPFYVDSGIRHKQEKTFLNRKEILKMTIMALAALLAIFLFSANKIHL
What is the function of this protein?
Catalyzes the exchange of L-arginine for agmatine.  The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response (By similarity).
What are the official names of this protein?
Arginine/agmatine antiporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HYPA_BRASO
Sequence: MHEMALCEGIVEIVEAEARKGAFSKVKTVWLEIGALSHVAPEALRFCFEAVTAHTIARGAALEIIEQKGSAWCLGCSRSVEISRRYDACSECGSHQLQVTGGEDMRVKELEVE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: ASTE_ECOLC
Sequence: MDNFLALTLTGKKPVITEREINGVRWRWLGDGVLELTPLTPPQGALVISAGIHGNETAPVEMLDALLGAISHGEIPLRWRLLVILGNPPALKQGKRYCHSDMNRMFGGRWQLFAESGETCRARELEQCLEDFYDQGKESVRWHLDLHTAIRGSLHPQFGVLPQRDIPWDEKFLTWLGAAGLEALVFHQEPGGTFTHFSARHFGALACTLELGKALPFGQNDLRQFAVTASAIAALLSGESVGIVRTPPLRYRVVSQITRHSPSFEMHMASDTLNFMPFKKGTLLAQDGEERFTVTHDVEYVLFPNPLVALGLRAGLMLEKIS
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: DNAA_PARP8
Sequence: MNEFWQHCSALLERELTPQQYVTWIKPLAPVAFDADANTLSIAAPNRFKLDWVKSQFSGRITDLARDFWHSPVDVQFVLDPKAGMRTAPAAPSRPPSAGVRNAAAAVDAAVGAVQAAHSARGGGMPGLGMPTNAAQLTDDAADLDLPSLDANEAAAARRTWRPGAAAQAAGGESDSTYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIHAIGNQLLMDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQEEFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVNLNEDVAFFVAKHLRSNVRELEGALRKILAYSKFHGREITIELTKEALKDLLTVQNRQISVENIQKTVADFYSIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIADERGKDAQLNHELHVLEQTLKG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHSO_BOMMO
Sequence: MTENYAAVLHGANDVRIEKIPVPEINDDEVLIKIDCVGICGSDVKLYSTGTCGADVIDKPIVIGHEGAGTVVKVGDKVSSLRVGDRVAIEPTQPCRSCELCKRGKYNLCVEPRYCSSMGAPGNLCRYYKHVADFCHKLPDNLTMEEGAAVQPLAIVIHACNRAKITLGSKIVILGAGPIGILCAMSAKAMGASKIILTDVVQSRLDAALELGADNVLLVRREYTDEEVVEKIVKLLGDRPDVSIDACGYGSAQRVALLVTKTAGLVLVVGIADKTVELPLSQALLREVDVVGSFRIMNTYQPALAAVSSGAIPLDKFITHRFPLNKTKEALDLAKSGAAMKILIHVQN
What is the function of this protein?
Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols.  Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2-oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity).  Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity).
What are the official names of this protein?
Sorbitol dehydrogenase, SDH, L-iditol 2-dehydrogenase, Polyol dehydrogenase, Xylitol dehydrogenase, XDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: UP3_HALAI
Sequence: MVPVARASLFTLACLLVSVCAQNFPGPPPGAVLRGPFPPARPSLTNRVHPPTSAAGMQLMRRMAVSEAVLSSDYTKRMTALDAIQNIPCVFRNPVLKYLLMDYMDMKPLPLPGSVQSQMSPATQSMILTDRGRRLQAGKLLNSRCVQSHDRLGALMYDIAEVPMAASAL
What are the official names of this protein?
Uncharacterized protein 3.
What are the subcellular locations of this protein?
Secreted.
Protein: 5NTC_HUMAN
Sequence: MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEEE
What is the function of this protein?
Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246).  In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705).  Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246).  Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705).  Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246).
What are the official names of this protein?
Cytosolic purine 5'-nucleotidase, Cytosolic 5'-nucleotidase II, cN-II, Cytosolic IMP/GMP-specific 5'-nucleotidase, Cytosolic nucleoside phosphotransferase 5'N, High Km 5'-nucleotidase.
What is the protein family that this protein belongs to?
Belongs to the 5'(3')-deoxyribonucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RL29_CHLAB
Sequence: MSVKKKLLAELRQKSLVELDAFIHENKKALFSLRAEAALQNKAVKTHLFSMYKKTIARSMTVKQEKEGKVDG
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: XK_MOUSE
Sequence: MKFPASVIASVFLFVAETAAALYLSSTYRSAGDRMWQVLTLLFSLMPCALVQFTLLFVHRDLSRDRPLALLMHLLQLGPLYRCCEVFCIYCQSDQNEEPYVSITKKRQMPKDGLSEEVEKEVGQAEGKLITHRSAFSRASVIQAFLGSAPQLTLQLYITVLEQNITTGRCFIMTLSLLSIVYGALRCNILAIKIKYDEYEVKVKPLAYVCIFLWRSFEIATRVIVLVLFTSVLKIWVVAVILVNFFSFFLYPWIVFWCSGSPFPENIEKALSRVGTTIVLCFLTLLYAGINMFCWSAVQLKIDNPELISKSQNWYRLLIYYMTRFIENSVLLLLWYFFKTDIYMYVCAPLLILQLLIGYCTGILFMLVFYQFFHPCKKLFSSSVSESFRALLRCACWSSLRRKSSEPVGRIDTDLKACTEQDVMPTTSKVIPEATDIWTAVDLCSA
What is the function of this protein?
Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane.
What are the official names of this protein?
Endoplasmic reticulum membrane adapter protein XK, Membrane transport protein XK, XK homolog, XK-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the XK family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CLC4M_NOMCO
Sequence: MSDSKEQRVQPLGLLEEDPTTSGIRLFPRDFQFQQTHGHKSSTGCLGHGPLVLQLLSFTLLAGFLVAILVQVYKGPSSLSQEQSEQDVIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSRLQEIYQELTRLKAAVGELPENSRLQEIYQELTQLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPDQSKQQQIYQELTDLKTAFERLCCRCPKDWTFFQGNCYFISNSQRNWHDSVTACQEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLSSSFQRYWNSGEPNNSGDEDCAEFSGSGWNDNRCNVDNYWICKKPTACFRDE
What is the function of this protein?
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver.  May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments.  Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.  Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity).
What are the official names of this protein?
C-type lectin domain family 4 member M, CD209 antigen-like protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: INHBC_MOUSE
Sequence: MASSLLLALLFLTPTTVVNPKTEGPCPACWGAIFDLESQRELLLDLAKKSILDKLHLSQRPILSRPVSRGALKTALQRLRGPRRETLLEHDQRQEEYEIISFADTDLSSINQTRLEFHFSGRMASGMEVRQTRFMFFVQFPHNATQTMNIRVLVLRPYDTNLTLTSQYVVQVNASGWYQLLLGPEAQAACSQGHLTLELVPESQVAHSSLILGWFSHRPFVAAQVRVEGKHRVRRRGIDCQGASRMCCRQEFFVDFREIGWNDWIIQPEGYAMNFCTGQCPLHVAGMPGISASFHTAVLNLLKANAAAGTTGRGSCCVPTSRRPLSLLYYDRDSNIVKTDIPDMVVEACGCS
What is the function of this protein?
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.  Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.  Inhibins appear to oppose the functions of activins.
What are the official names of this protein?
Inhibin beta C chain, Activin beta-C chain.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RM41B_XENLA
Sequence: MGLITKIARGLVRGADRMAECTSKLGPNSYNKGRGAKKIGYLTSSGKFVKVREMVPVFVVPDLTGFKLKPYVSYKAPPGTEDPMTAKKLFMETVGPQIEKDLQESTFRPEDLEKYGFEPTQEGKLFKLFPRNYIQ
What is the function of this protein?
Component of the mitochondrial ribosome large subunit.  Also involved in apoptosis and cell cycle (By similarity).
What are the official names of this protein?
39S ribosomal protein L41-B, mitochondrial, L41mt-B, MRP-L41-B.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL41 family.
What are the subcellular locations of this protein?
Mitochondrion.