PharMolix/UniProtQA huggingface dataset:
Protein: EFP_BURP6
Sequence: MKTAQELRVGNVVMIGNDAWVVSKTEYNKSGRNAAVVKMKLKNLLNGGGQESVYKADDKFEVVVLDRKEVTYSYFADPMYVFMDADYNQYEVEAEMMGDALNYLEDGMACEVVFYNEKAISVELPTILVREITYTEPAVKGDTSSGKVLKNAKLATGFELQVPLFCNTGDKIEIDTRTNEYRSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_DESVH
Sequence: MDMDSILLDAEERMEKAIAALEREFSRLRTGRASASLVDGIKVDYYGTPTPISQVASVAVPDSRCITIQPWDRNAFSLIEKAILKSDLGLNPVNDGKIIRINIPPLTEERRKDLGKMARKYAEEAKVAVRNVRRDANEQLKKLEKNKELSEDDLRKAQEDVQKLTDRFVAKTDEKAGAKEKEIMDI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_ACTP2
Sequence: MQHLKELTEKARNALDALDQGLDALEEFRVEYFGKKGHFTALMQELRNVSAEERPAIGAKINEAKQAILDILNAKKEAWEQEALNAKLAAESIDVSLPGRKTELGGLHPVSITIERVVKFFSELGFTVASGPEIETDYYNFDALNIPAHHPARADHDTFWFDAQRLLRTQTSGVQIRTMENMQPPIRIVAPGRVYRNDYDQTHTPMFHQIELLYVDKKANFTELKGLIHDFLKAFFEEDLQVRFRPSFFPFTEPSAEVDVMRQNGKWLEVLGCGMVHPNVLRNVGIDPEEYSGFAVGMGVERLTMLRYNVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCIMP_MOUSE
Sequence: MSWWRDNFWIILAMSIIFISLVLGLILYCVCRWQLRQGRNWEIAKPSKQDGRDEEKMYENVLNSSPGQLPALPPRGSPFPGDLAPQEAPRQPSAWYSSVKKVRNKKVFAISGSTEPENDYDDVEIPATTETQHSKTTPFWQAEVGLHSSF
What is the function of this protein?
Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:27288407, PubMed:28290451, PubMed:28098138).  It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (By similarity).  In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (PubMed:27288407).  It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (PubMed:28098138).
What are the official names of this protein?
SLP adapter and CSK-interacting membrane protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Cell projection, ruffle. Cell projection, filopodium. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs) (By similarity). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen- presenting cells (APCs) and T-cells (By similarity). Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod (By similarity). Present at regions of cell-cell contacts but also at the leading edge of migrating cells (By similarity). Localizes to phagosomes in dendritic cells after exposure to particulate beta-glucan (PubMed:27288407).
Protein: TLR10_HUMAN
Sequence: MRLIRNIYIFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINVNVLATREMYELQTFTELNEESRGSTISLMRTDCL
What is the function of this protein?
Participates in the innate immune response to microbial agents.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
What are the official names of this protein?
Toll-like receptor 10.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: POLS_ONNVG
Sequence: MEFIPAQTYYNRRYQPRPWTQRPTIQVIRPKPRRRRPAGQLAQLISAVSRLALRTVPQKPRRTRKIKKQKQVKQEQQSTTNQKKKAPKQKQTQKKKRPGRRERMCMKIENDCIFEVRHEGKVTGYACLVGDKVMKPAHVKGTIDNADLAKLAFKRSSKYDLECAQIPVHMKSDASKFTHEKPEGYYNWHHGAVQYSGGRFTIPTGAGKPGDSGRPIFDNKGRVVAIVLGGANEGTRTALSVVTWNKDIVTKITPEGSVEWSLALPVMCLLANTTFPCSQPPCAPCCYEKKPEETLRMLEDNVMQPGYYQLLDSALACSQRRQKRNARENFNVYKVTRPYLAHCPDCGEGHSCHSPIALERIRSEATDGTLKIQVSLQIGIKTDDSHDWTKLRYMDSHTPVDADRSGLFVRTSAPCTITGTMGHFILARCPKGETLTVGFVDSRRISHTCMHPFRHEPPLIGREKFHSRPQHGKELPCSTYVHTTAATAEEIEVHMPPDTPDYTLMTQQAGNVKITVDGQTVRYKCKCDGSNEGLITADKVINNCKVDQCHTAVTNHKKWQYNSPLTPRNSEQGDRKGKIHIPFPLVNTTCRVPKARNPTVTYGKNRVTLLLHPDHPTLLSYRAMGRIPDYHEEWITNKKEISITVPAEGLEVTWGNNDPYKYWPQLSTNGTAHGHPHEIILYYYELYPTTTIAVLAAASIVITSLVGLSLGMCICARRRCITPYELTPGATIPFLLGVLCCARTAKAASYYEAATYLWNEQQPLFWLQLLIPLSAAIVVCNCLKLLPCCCKTLTFLAVMSIGARTVTAYEHATVIPNTVGVPCKTLVSRPGYSPMVLEMELQSVTLEPALSLDYITCEYKTITPSPYVKCCGTAECKAKNLPDYNCKVFTGVYPFMWGGAYCFCDAENTQLSEAHVEKSESCKTEFASAYRAHTASVSAKLRVFYQGNNITVSAYANGDHAVTVEDAKFVIGPLSSAWSPFDNKIVVYKGEVYNMDYPPFGAGRPGQFGDIQSRTPDSKDVYANTQLILQRPAAGAIHVPYSQAPSGFKYWLKEKGASLQHTAPFGCQIATNPVRAVNCAVGNIPVSIDIPDAAFTRVTDAPSITDMSCEVASCTHSSDFGGAAVIKYTASKKGKCAVHSVTNAVTIREPNVDVKGTAQLQIAFSTALASAEFKVQICSTLVHCSATCHPPKDHIVNYPSPHTTLGVQDISTTAMSWVQKITGGVGLVVAIAALILIIVLCVSFSRH
What is the function of this protein?
Class II viral fusion protein.  Fusion activity is inactive as long as E1 is bound to E2 in mature virion.  After virus attachment to target cell and endocytosis, acidification of the endosome would induce dissociation of E1/E2 heterodimer and concomitant trimerization of the E1 subunits.  This E1 trimer is fusion active, and promotes release of viral nucleocapsid in cytoplasm after endosome and viral membrane fusion.  Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane.  Fusion is optimal at levels of about 1 molecule of cholesterol per 2 molecules of phospholipids, and is specific for sterols containing a 3-beta-hydroxyl group.
What are the official names of this protein?
Structural polyprotein, p130.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm. Host cell membrane. Host nucleus. Note=Shuttles between the cytoplasm and the nucleus. SUBCELLULAR LOCATION: [Spike glycoprotein E2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [6K protein]: Host cell membrane; Multi-pass membrane protein. Virion membrane; Multi- pass membrane protein. SUBCELLULAR LOCATION: [Spike glycoprotein E1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: Y1013_STAA9
Sequence: MILGLALIPSKSFQEAVDSYRKRYDKQYSRIKPHVTIKAPFEIEDGDLDSVIEQVRARINGIPAVEVHATKASSFKPTNNVIYFKVAKTDDLEELFNRFNGEDFYGEAEHVFVPHFTIAQGLSSQEFEDIFGQVALAGVDHKEIIDELTLLRFDDDEDKWKVIETFKLA
What are the official names of this protein?
Putative phosphoesterase SaurJH9_1013.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. YjcG family.
Protein: SYFA_ECOL5
Sequence: MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKAELESAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDATRLLRTQTSGVQIRTMKAQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCA_SALDC
Sequence: MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLPDHEGRHLLPSVVHYQQQGHTVGYAARDNAAQDTANTISSVKRMMGRSLADIQARYPHLPYRFKASVNGLPMIDTAAGLLNPVRVSADILKALAARASESLSGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGKEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQAGIADRSDNRVQRELLDAAIAAKIALSDADTVRVNVAGWQGEITREQFNDLISALVKRTLLACRRALKDAGVDPQDVLEVVMVGGSTRVPLVRERVGEFFGRTPLTAIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPPLPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDGEIASMIKDSMSFAEQDVKARMLAEQKVEAARVLESLTGALTADAALLSAAERQCIDDAAAHLSAVAQGDDVDAIEQAIKNVDKQTQEFAARRMDQSVRRALKGHSVDEV
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: SYP_CAMC5
Sequence: MRFSKFYAPTTKEAPKDASLPSHIFLVRGGFVEQIGSGLYNFLPLGKMMLDKITKVVKEEMDAAGVLEVSFSVVTSGELWKQSGRFNVFGKELLRFKDRKENDFVLSPTNEEAAVALVRGKVTSYKQLPLNIYQINTKFRDEARPRFGLLRGREFTMKDAYSFHANEADMKREFDLMEATYSKIFTRLGLNFRAVEADSGAIGGSGSKEFMVLAKNGEDDILCCDSCKYAANVEAAKRAKKTSDAPAPQADATKFYTPDAKTIKAVAEFFKVDEFYTIKAVIKKAIYEDTQKIVAFFVRGNDELQETKAQNACGALELVDASEDEVAAAGLVAGFCGPVGLSGVDFYIDNELKGQTQMICGANEKDYHFVGVSVSSFNDERFKDLVSVQAGDICPKCGGKLELSKGIEVGHIFQLGYKYSSAMGATFLDENGKARPFLMGCYGIGVSRLIAVMVEASHDDRGCVWKKECTPFECEIVISNLKDEAGVKFATKLYENLRNLGLCVLLDDRNERFGVKMNDFELLGFPYAIIVGKGLENGEVELITRDGLVKEVVKKDEILSVLKEKLC
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERG28_ARATH
Sequence: MKALGYWLMVVGSLRLASVWFGFFNIWALRLAVFSQTTMSEVHGRTFGVWTLLTCTLCFLCAFNLENKPLYLATFLSFIYALGHFLTEYLFYQTMTIANLSTVGFFAGTSIVWMLLEWNSLEQPHSKLS
What are the official names of this protein?
Ergosterol biosynthetic protein 28.
What is the protein family that this protein belongs to?
Belongs to the ERG28 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS13_MESHJ
Sequence: MARVLNVEIPNHKRIVIALCSIFGIGKSLATEIVEKTAKLQEEKFGKKFPILTENTKVKEINEEVLQVIRDVAKTYKTEGDLHREVQSNIKRLIEIKCYRGIRHRKGLPVRGQVTQKNARTRKGPRKTIMAKKDKGK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RNZ_STRT1
Sequence: MELQFLGTGAGQPSKARNVSSLVLKLLDEINEVWMFDCGEGTQRQILETTIKPRKVKKIFITHMHGDHIFGLPGFLASRSFQSSEEQTDLEVYGPVGIKQYVMTSIRTSGTRLSYHVHFKEIDENSLGLVMEDDKFAVYADKLDHTIFCVGYRVVQKDLEGTLDAEALKAAGVPFGPLFGQIKNGQDVVLEDGTKIIAKDFISAPKKGKVITILGDTRKTNASVRLGLGADVLVHESTYGKGDEKIAKSHGHSTNMQAAQVARDASAKRLLLNHVSARFLGRDIGKMAADAKTIFENTHIVRDLEEVEI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: FER4_METJA
Sequence: MAVTIDYSLCKGAECAECVNNCPMEVFEIEGDKVVVARPDDCTYCGVCEDVCPTGAVKVEPE
What are the official names of this protein?
Uncharacterized ferredoxin MJ0199.
Protein: Y2405_EXIS2
Sequence: MEQNQPQLVIITGMSGAGKTVAMNSFEDLGYFCVDNLPPTLLPQLIEVIGQVRPKIAVAIDTRARDFIDSFFVVYEDLKKTNLQIRMLYLDARNDVLVRRYKESRRSHPLAPTASPLIGIERERTLLEGFRDKAQLLMDTSDIKPLALKERILKEFTEGERIPFTVNVMSFGFKHGLPLDADLVFDLRFLPNPFYIPELRPKTGLDLEVSSYVMQWPEAKLFYKKLVDMLEFLIPQYEREGKSQLVVALGCTGGKHRSITFAEAISKEFKNQYHIVTNHRDYVHAKEEK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Exig_2405.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: MUTL_STAA1
Sequence: MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSKLDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYIKSLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPEHSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSKIQEAFKDRILIPKNNLDYVPKKNKVLYSFEQQKIEFEQRQNTENNQEKTFSSEESNSKSFMAENQNDEIVIKEDSYNPFVTKTSESLITDDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNEDASVQNYENKASDDYYDVNDIKGTKSKDPKRRIPYMEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIMLEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREAEDPFTCPHGRPIIINFSKYELEKLFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: KCC3_CAEEL
Sequence: MSNARRRFSTVTQINTEGLQAMGKGGGRMETVGEDGIPADYKGNRKFTTSLGHLALYKEDEGIGTQASFISGYTTPGPKERATSEHVKANLGVMLGVYLPTIQHILGVTMFIRLFWVVGMSGVAWTMALLAICCLSTLLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLANTVAASMYIVGGVEVILMYLWPEMAIGGADALHDTEMFGSLYNNLRLYGTVFLLIQALIVAMGVKFVQLLAPVSLMCVILAIAACIGGGIEKQITMEGMKVCAIDNHLLQSSIVTHPIHKNQTSWFNETVDFCNLCDKSLYLESVFCANVNNDEASAEDDVFCTHYTSKKMTCQLAFPGFNMKTLNDNMWPEYMEKSEVVPGVRGKETAEVVQDESSTFFMLMAIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLRDKFGRSIGNTMVVAALSWPHPAVVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPILAPFARVTKNNEPFLGLVLTVIIAECGILLGAVDKIAEVLDFFFLMCYAFVNLIAVLHSVLKSPNWRPRFKYFHWTLSLLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALTTAQYSLLKVEDKDPHPKNWRPQVLILLTSQWSKEMIDRRAVSMLNLGAQLKAGRGLAIACAFLKGSVDSQKDKNRARDVKTTLVKDMSSVRLRGFAKTMFYNNHQINGTISGLYQSIGIGGLRPNTILLNWPNEKNPDELVLFAEEIIHGAANDNCLIVTKGITDFPEYSERLTGFIDIWWIVQDGGILMLIAYLLRQHKVWKGCTLRIFAVSEQDSTKSEDMKAGLQKYIYMLRIDAELFIVDLLDMEVSDEVVEKAAEVERKQKEREEMRRSKSGYLNDGFMEDNGKPRQVMMRHSDSARSFSPQPGAHTSINLDETETSFTESLFDDFYRSGTPNEDLEGAMKLNIHKMNTSVRLNRVIRENSPDSQLILLNLPSPPRNRLAFNNSYMTYLDVLTEDLPRVLFIGGSGREVITIDS
What is the function of this protein?
Probable potassium/chloride cotransporter that functions in the amphid sheath glial cells to regulate thermotaxis behavior (PubMed:26463820, PubMed:27062922).  By maintaining chloride homeostasis, negatively regulates guanylate cyclase gcy-8 in the thermosensory AFD neurons and thereby controls the microvilli receptive ending morphology of the AFD neurons and thermotaxis (PubMed:27062922).  Modulates the temperature-evoked neuronal activity of the AFD neurons such as calcium responses to temperature gradients (PubMed:26463820).  Might also play a role in the chemotaxis behavior mediated by the sensory neurons AWA and AWC (PubMed:26463820).
What are the official names of this protein?
Potassium/chloride cotransporter 3.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the amphid sheath glia apical domain in which the AFD microvilli are embedded.
Protein: DSRB_YERPS
Sequence: MKVNDRVTVKTDGGPRREGVVLEVEEFSEGVMYLVSLADYPAGVWFFNEVDSQDGTFVEPLSQ
What are the official names of this protein?
Protein DsrB.
What is the protein family that this protein belongs to?
Belongs to the DsrB family.
Protein: SYT_CLOBM
Sequence: MIKITLKDGKVMEFEEGIKISDIAMKISPALYKKALAAKIDGETVDLMTELHKDSSLEILTFEDEMGKWALRHTGAHILAQAVKRLYPEVKLAIGPAIDTGFYYDFEADFTFTPEMLEKIEAEIKKIIKENHKLERFELPREEAIDLMKEKNEDYKVELIEDLPEGEVISFYKQGDFTDLCAGPHVPSTGKVKSVKLLSLAGAYWRGDENNKMLQRIYGTAFTKKSELDEYLNMLEEAKKRDHRKLGKELDLFSIHEEGPGFPFFHPKGMIIRNILESFWREEHTKAGYQEIRTPLILNEALWHQSGHWDHYKENMYFTNIDDGDYAIKPMNCPGGILVYKNSMHSYRDLPLRLSELGIVHRHELSGALHGLMRVRCFTQDDAHLYMTKEQIKEEIVGIIKLIDKFYKLFGFEYFVELSTRPEDSMGSDEDWEIATNGLREALDSIGKEYRVNEGDGAFYGPKIDFHLKDCIGRTWQCGTIQLDFQMPERFDLSYIGADGEKHRPVMVHRTIYGSVERFIGILIEQYAGAFPTWLAPVQVKLMNITDAQYDYLKKVEEALKENNIRVEIDTRNEKIGYKIREAQLQKIPYMLILGDKEVEAGKVAVRSRKDGDLGAISLEEFIEKIKNEIKVKTN
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA_ECOSE
Sequence: MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADTTLLTDRAAMLGLPLTLRPYSPNSPAQPQTTGTLTLLPVALRESVTAGQLAIENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLDELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGEADVGSFITALNLAIKMIVNTQ
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_PSYA2
Sequence: MSNIPAELKYIASHEWLRLEDDGTITVGITDHAQDLLGDVVFVELPDVGDIIAVDDEISVVESVKAASDVYAPISGEVVAINEALEDDPEIINSDPYGEGWFFRMKPDNIADYEALLTADEYENEL
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: MATK_VACFA
Sequence: MEEFQVYLELDRXRQHDFLYPLIFREYIYALAYDHGLNSSILVQNXGYDNKSSLLIVKRLITRMYQQNHLIISANNSNKNPFWGYNKNLYSQIMSEGLAVSVEIPFSLQLISSLEKAEIIKSYNLRSIHSIFPFFEEKFPYLNYVSDVQIPYPIHLEILIQTLRYWVKDASSFHLLRLFLYEYCNWNSLITPKKRISTFSNSKSNPXFFSKSNPXFFLFLYNFXVCEYXSIFLFLRTKSSYLXLXSFGVLFERIYFYAKIKHFVKVFDKDFPSTLWFFKDPFIHYVXYQGKSILASXNTPFLMKKWKYFLIHLWQXXXXXXXXXXXXXXXXXXXXXXXFLGYFSNVQXNPSVVRSQMLEKSFIMENLMKKLDTIIPIIPLXRSLAKAKXCNVLGHPISKPVWADSSDFDIIDRFLQICRDLSXYYNGSSKKKSLYRIKYILRLSCIKTLARKHKSTVRFFLKRLGSELLEEFFTEEEDLFSLIFSRASSTLQKLDRGRIWYLDIFYFHQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RM02_MOUSE
Sequence: MALCALTSALRSLSLASAAITARVPTLLPAAQIQSNVLLQLPPALVSPSYRPVHMSADRSAKFVSWKSRTKYTVKPVKMRKSGGRDHTGRIRVHGIGGGHKQNYRMIDFLRFRPEKEKAPEPFEEKVVVVRYDPCRSADIALVAGGSRKRWIIATENMKAGDTILNSNHIGRMAVAAQEGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLLRKVNGTAIIQLPSKRQMQVLESCTATVGRVSNVNHNQRVIGKAGRNRWLGKRPNSGLWQRKGGWAGRKIRPLPPMKSYVKLPSAAAQN
What are the official names of this protein?
39S ribosomal protein L2, mitochondrial, L2mt, MRP-L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FEZ_ARATH
Sequence: MGDRNNDGDQKMEDVLLPGFRFHPTDEELVSFYLKRKVQHNPLSIELIRQLDIYKYDPWDLPKFAMTGEKEWYFYCPRDRKYRNSSRPNRVTGAGFWKATGTDRPIYSSEGNKCIGLKKSLVFYKGRAAKGVKTDWMMHEFRLPSLSEPSPPSKRFFDSPVSPNDSWAICRIFKKTNTTTLRALSHSFVSSLPPETSTDTMSNQKQSNTYHFSSDKILKPSSHFQFHHENMNTPKTSNSTTPSVPTISPFSYLDFTSYDKPTNVFNPVSCLDQQYLTNLFLATQETQPQFPRLPSSNEIPSFLLNTSSDSTFLGEFTSHIDLSAVLAQEQCPPLVSLPQEYQETGFEGNGIMKNMRGSNEDHLGDHCDTLRFDDFTSTINENHRHHQDLKQNMTLLESYYSSLSSINSDLPACFSSTT
What is the function of this protein?
Promotes periclinal root capforming cell divisions.  Activates expression of its negative regulator SMB in a feedback loop for controlled switches in cell division plane.
What are the official names of this protein?
Protein FEZ, NAC domain-containing protein 9, ANAC009.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRC_SHEWM
Sequence: MTQITLLTPDDWHLHFRDGDMLQETVPATARLFQRAIVMPNLLPPVTDAKLASAYRERILAARPEGSSFEPLMTIFLTNDTSKQDIIDAKAAGVVAAKLYPAGATTNSDAAVKGLDALFPIFETMAEIGMLLLVHGEVTESHIDIFDREALFIERNLSRIVDAFPQLKVVFEHITTKEAAEFVTSASDNVAATITPQHLLLNRNDLLVGGVRPHNFCLPVLKRNIHQEALRAAVATGSSKFFLGTDSAPHEKHRKESACGCAGCYSAWSALELYAQVFDDLGVIEKLEGFASTHGPDFYGLPRNTGTVTLVKESWTVPSEIILPNGNPIVPFFAGEEVNWKVKS
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.