PharMolix/UniProtQA huggingface dataset:
Protein: TGT_ESCF3
Sequence: MKFELDTTDGRARRGRLVFDRGVVETPCFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGNKNALFGIIQGSVYEDLRDISVKGLVDIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKYKSDTGPLDPECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: ALDH2_PIG
Sequence: MLRPAALAAARLVLRQGRRLLSAAPTQAVPAPNQQPEIFYNQIFINNEWHDAISKKTFPTVNPSTGDVICHVAEGDKEDVDRAVEAARAAFQLGSPWRRLDASDRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTLPIDGDYFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVSEQTPLTALYVANLIKEAGFPPGVVNIVPGYGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGKSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYAEFVERSVARARSRVVGNPFDSRTEQGPQIDETQFKKILGYIKSGKEEGAKLLCGGGAAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVIGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKLSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
What is the function of this protein?
Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
What are the official names of this protein?
Aldehyde dehydrogenase, mitochondrial, ALDH class 2, ALDH-E2.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ATAJ_ASPTN
Sequence: MTTDLNQNPYLVRAQQLLCRVPLIDGHNDFPFIIRGLYQNNLTRASLNDLPIGQTDISRLRQGSVGGQFWSAYVPNPVHSDKESDEAYLECLRQTLQQIDVIHRMVSEHPDVFGLAQSAADVWKIFRAGRIASLIGIEGLHQIAHSPSALRMMHKLGVRYATLCHTKNNRYCDSAVDRHTSSPWSEYGGQTHDPGDEPSRNVRTGFHSLTLKYLTAVHGRIVDLSHTSEATQRDAIAISKAPVIFSHSASSSLTPSPRNVTDEILHQLKRNGGLIMVCFLRDLVNSADDANTTGSRVVDHILYIAETIGYDHVGIGSDFDGMLEGPLGLDDVSRFPELVADLFRRGVSEERIEKIVGLNTLRVMKQVEDVAVREQAEGSTGVLCDVVKPIWTAEQRQMLAEQGRTRGLRP
What is the function of this protein?
Dipeptidase; part of the gene cluster that mediates the biosynthesis of acetylaranotin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide-bridged cyclic dipeptide (PubMed:23586797).  The first step of acetylaranotin biosynthesis is performed by the NRPS ataP which produces diketopiperazine cyclo-L-Phe-L-Phe via the condensation of 2 phenylalanines (L-Phe) (PubMed:23586797).  The ataC domain of ataTC then catalyzes the formation of bishydroxylation of cyclo-L-Phe-L-Phe (PubMed:23586797).  The glutathione S-transferase domain ataG in ataIMG further catalyzes the conjugation of two glutathiones to the bishydroxylated intermediate (PubMed:23586797).  Next, the dipeptidase ataJ removes the Glu residues (PubMed:23586797).  The following step is performed by the carbon sulfur lyase domain ataI of ataIMG which may convert the bis-cysteinyl adduct to yield an epidithiol intermediate (PubMed:23586797).  The ataT domain from ataTC then catalyzes the oxidation of the free dithiols, followed by a cyclization step catalyzed by the cytochrome P450 ataF (PubMed:23586797).  AtaF probably acts as an epoxidase to promote a dual epoxidation formation at C8 and C9 along with C8' and C9', followed by the spontaneous nucleophilic attack of the amide nitrogens N10 and N10' to yield an intermediate with the pyrrolidine partial structure (PubMed:23586797).  The final steps of acetylaranotin biosynthesis involve the acetylation and ring rearrangement of an epitetrathiodiketopiperazine intermediate to produce acetylaranotin (PubMed:23586797).  AtaH probably catalyzes the acetylation of epitetrathiodiketopiperazine to produce a diacetate and ataY is responsible for the formation of the dihydrooxepin moiety that converts the diacetate intermediate to acetylaranotin via acetylapoaranotin (PubMed:23586797).  Both enzymes could function independently in the absence of the other (PubMed:23586797).  The acetylaranotin bis-thiomethyltransferase ataS located outside of acetylaranotin gene cluster is the main thiomethyltransferase responsible for converting acetylaranotin and its related intermediates to their methylated forms (PubMed:30096370).
What are the official names of this protein?
Dipeptidase ataJ, Acetylaranotin biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
Protein: RS6_SALPC
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYSAAITGAEGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQEVIDELETTFRFNDAVIRSMVMRTKHAVTEASPMVKAKDERRERRDDFANETADDAEAGDSEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: LEPA_BURCH
Sequence: MDHIRNFSIIAHIDHGKSTLADRIIQVCGGLADREMEAQVLDSMDIERERGITIKAQTAALSYRARDGKVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIELGVEVVPVLNKIDLPAANPENAIEEIEDVIGIDATDATRCSAKTGLGVEDVLESLIAKVPPPKGDPAAPLQALIIDSWFDNYVGVVMLVRIVNGTLRPKDKIKMMATGAQYPVEHVGVFTPKSRNLDSLSAGQVGFIIAGIKELTAAKVGDTVTHAAKAAAEPLPGFKEVKPQVFAGLYPVEANQYDALRESLEKLKLNDASLQYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDMDLITTAPTVVYEVVQSDGSTIMVENPAKMPEPGRIAEVREPIVTVNLYMPQDYVGSVITLCEQKRGSQINMQYHGRQVQLTYEIPMAEIVLDFFDRLKSVSRGYASMDYEFKEYRSSDVVKVDMLINGDKVDALSIIVHRSQSQYRGREVAAKMREIIPRQMYDVAIQAAIGAHIVARENIKALRKNVLAKCYGGDITRKKKLLEKQKEGKKRMKQVGSVEIPQEAFLAILRVEDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYFA_STAA9
Sequence: MSEQQTMSELKQQALVDINEANDERALQEVKVKYLGKKGSVSGLMKLMKDLPNEEKPAFGQKVNELRQTIQNELDERQQMLVKEKLNKQLAEETIDVSLPGRHIEIGSKHPLTRTIEEIEDLFLGLGYEIVNGYEVEQDHYNFEMLNLPKSHPARDMQDSFYITDEILLRTHTSPVQARTMESRHGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDKNVKMSDLKGTLELLAKKLFGADREIRLRPSYFPFTEPSVEVDVSCFKCKGKGCNVCKHTGWIEILGAGMVHPNVLEMAGFDSSEYSGFAFGMGPDRIAMLKYGIEDIRHFYTNDVRFLDQFKAVEDRGDM
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLX4_COCIM
Sequence: MSHLDLTRHRTRSPSPSQIFGSSTTPVATNSTHSEPSASSILRSILGEYADPKRPDVSGADPIRCPVKRVHKTPAVRASSPGRENVPVRTLQSSKDAEGDNFSGDGQLTPCGGPRPLAERLSPKLLAKQTRRKGVGAQKRTKGCDLVDRILTGRSIKASATAASKSSDLPQPQRKGIPTLVKEANPGEADWEDEGLQLEPATKRKYSWTPVKDTNLSIIDLTANSGSSPPSIPGREAQKFTSLVSRYGFAETSPLAMKNEFPEDFPTRKRQLDLLQGTTNSSSSEGSSNKSSGKCPLKVNGTKGRRSRKVTTITSLSTAQYGLKDSPVESFPSVDTTERPSGKRSKSQTKKGGNKKPAGVSDFKVAPTTDALKSLEDQVYLFGTSSQLERVSSDEDKLGVPSAPASSRQSARDRTSVSTLSKYKVSRNLWAAGWRDLDGSVADIEIVDMVNIDTPKSHESSTLTLPSTSTNASNQGFSSQNTINDRSKPSQTTSTTTESTGVESGQLVVPSLCEDLSEKAGYPAVPERETLSSREIASSESAYIETMPSFRGFTTAELAQKVAAFGFKPIKSREKMISLLEKCWQSQHKNSAPTSLPANNANPPDSHASGQKNVVRCDTGGSNASHTTKRASKAPQKKQSTSSTSHSAKAGPKQVDCSQERPNHAYLPHDSTQASSQPVIVIPDSEESGDDFQDTYLGSLNRTSSTNYHPLSANSIPDGSPLFLRTISQASTEEKTSDPSDINQQITRAIKAQPRMTAINGMKRPTWLEKILMYDPIWLEDLTVWLNTEGLDRVGEDREVSRLTVREWCESKGICCTWKKPT
What is the function of this protein?
Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX4.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEM4_YEAST
Sequence: MSSRKKVRVLLLKNKTVPIDKYELECRSKAFEPIFVPLIKHTHVIQDFRNVLNTIPNYLNTINYIIITSQRTVESLNEAIIPTLTSEQKAALLSKTVYTVGPATANFIRRSGFINVKGGEDAGNGSILADIIIDDLSTDIKACPPSELLFLVGEIRRDIIPKKLHSKGIKVREVVTYKTEELSDGFKRFIHAMKECDEDEVFSDWVVVFSPQGTKEITQYLGDSNRLPGSHLRVASIGPTTKKYLDDNDVTSDVVSPKPDPKSLLDAIELYQRHK
What is the function of this protein?
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the fourth step in the heme biosynthetic pathway.
What are the official names of this protein?
Uroporphyrinogen-III synthase, UROIIIS, UROS, Hydroxymethylbilane hydrolyase [cyclizing], Uroporphyrinogen-III cosynthase.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen-III synthase family.
Protein: YNBB_ECOLI
Sequence: MLEKSLATLFALLILATLINRFLLWRLPERKGGEVTLRIRTWWGIVICFSMVISGPRWMTLTFFALISFLALKEYCTLISVHFPRWLYWGIPLNYLLIGFNCFELFLLFIPLAGFLILATGQVLVGDPSGFLHTVSAIFWGWIMTVFALSHAAWLLMLPTTNIQGGALLVLFLLALTESNDIAQYLWGKSCGRRKVVPKVSPGKTLEGLMGGVITIMIASLIIGPLLTPLNTLQALLAGLLIGISGFCGDVVMSAIKRDIGVKDSGKLLPGHGGLLDRIDSLIFTAPVFFYFIRYCCY
What are the official names of this protein?
Uncharacterized protein YnbB.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SAHH_SYNS9
Sequence: MVAAPTTATELKLGTDCVIADINLAAFGRKELDIAETEMPGLMALRAKYGNEKPLKGARIAGSLHMTIQTAVLIETLEELGADVRWASCNIFSTQDHAAAAIAANGTPVFAVKGETLEEYWAYTHRILEWSDGGAPNMILDDGGDATGLVILGTKAEQDITVLDNPSNEEETFLFASIKKKLAEDSSFYSRTKAAIQGVTEETTTGVARLYKMQKSGELPFPAINVNDSVTKSKFDNLYGCRESLVDSIKRATDVMVAGKQALVVGYGDVGKGSAQSLRGLGATVCIAEVDPICALQAAMEGYRVVRLDDVVDQMDIFVTATGNYQVIRNEHLVKMKDEAIVCNIGHFDNEIDVASLKDYKWDNIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFTKANEYGKEVYVLPKHLDEMVARLHLSKIGANLTELSKDQADYINVPVEGPYKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_RHILO
Sequence: MTGYFSFPFPRRTSVGVDVGGVAVGGGAPVVVQSMTNTDTADIDQTVAQVAALHRAGSEIVRITVDRDESAAAVPRIHERLQRLGINVPLVGDFHYIGHKLLADHPACAEALAKYRINPGNVGFKDKKDRQFTDIVEMAIKHDKPVRIGVNWGSLDQELLTRLMDDNQDKGFPLTAQEVTREAIVQSAILSAEMAEEIGLGRDKIILSAKVSGVQDLIAVYTELATRSDHALHLGLTEAGMGSKGIVASSAAMGILLQQGIGDTIRISLTPEPNGDRTREVQVAQELLQTMGFRQFVPIVAACPGCGRTTSTVFQELAQNIQADLRKNMPVWREKYPGVENLKVAVMGCIVNGPGESKHADIGISLPGTGETPTAPVFVDGKKAATLRGTSIAADFEKMVTDYIEQRFGRGGKAAAE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: PUR9_SYNE7
Sequence: MPRFALLSVSDKTGLVDFARQLVDRFQFQIVSSGGTAKQLLEAGIPVTKVAEHTGSPEILGGRVKTLHPRIHGGILARRDREEDQADLAANNIQPFDLVVVNLYPFEATIARPEVTLADAIEQIDIGGPAMVRASAKNHAHLTILTNPSQYEPYLTALADGEGQIPLAFRQQCALAAFQHTAAYDAAIATYLAEQFEATSDRLQLSAQPVQVLRYGENPHQAATWYQTGATASGWAAAQQLQGKELSYNNLVDLEAARQIIAEFPADGPAAAAILKHNNPCGVATAEALSDAYQKAFDADSVSAFGGIVALNRAIDAATATAMTGTFLECIVAPSVEPAAAEILAAKKNLRVLTLADFNSGPQQTVRSIAGGFLVQDSDDQLETVDAWQVVTEQQPSEADWQELLFAWKVVKHVKSNAIAVTANGVTLGIGAGQMNRVGSVKIALEQAGDRAQGAILASDGFFPFDDSVRTAAAAGIRAIVQPGGSLRDADSIAAANELGLVMVFTGTRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: KCY_THEM4
Sequence: MPCRIAIDGPAGSGKTTVAKLLADALGIFYLDTGAMYRIVGLYLSENNVESDEEIERKLKELKITFSNGNFFLNGRKIGNEIRTPEIGIYASKYAKRLPVRNYLTKIQREIAKNQSIVVEGRDIGTVVLPDAEVKIFLVASQEARAKRRYKELMEKGVEVTFEEVLSEIVLRDKQDSERDVAPLKKAKDAILIDTTNLSIEEVIERILKVVKEKCKL
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_MESH7
Sequence: MSRKKQAPVRNVLADPVFNSKLITKAINCTMLEGKKTTAQNILYSAFKLVEEKLQKDALEVFRQAVKNVTPLTEVRSRRIGGTNYQVPMEVRQKRQQTLALRWLILFARKRNEKTMIVKLANEIIDAYNKTGGAFKKKEDTHKMAEANRAFAHFKW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ASSY_STRT1
Sequence: MSKEKVILAYSGGLDTSVAITWLKKDYDVIAVCMDVGEGKDLEFIHDKALTVGAVESYVLDVKDEFAEDYVLPALQAHAYYEQKYPLVSALSRPIIAKKLVEIAHKTGATTIAHGCTGKGNDQVRFEVAIAALDPSLKVVAPVREWKWSREEEIEYAKANGVPVPADLDNPYSVDQNLWGRANECGVLENPWNQAPEEAFGITNSPESAPDEAEYVDVTFKEGKPVALNGKEMKLADLIQEMNVIAGKHGVGRIDHVENRLVGIKSREIYECPGAIALLTAHKEIEDLTLVREVSHFKPILENELSNLIYNALWFSPATEAIIAYIKETQKVVNGIAKVKLYKGHAQVVARQSANSLYDENLATYTSADSFDQDAAIGFIKLWGLPTQVNSQVNHPFDK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLH_TETTS
Sequence: MELRTKTLNIQPPKKPFSNTYQAFVLEKKNALGKNFDNKKVQADYNKLSNNEKERLQKLVDNAEEKYKEELFHYNNHIQGKGKQKYVPQVKVPEKPKKPIGSFFRFLEENRQKYAAKHKDLTNAKILKIMSEDFNNLPQKEVKVYEDAYQKEYAQYLVEFKKWNEKYGQAAQKKQTKRKNSTSKSRRSSSKGKSSVSKGRTKSTSSKRRADSSASQGRSQSSSSNRRKASSSKDQKGTRSSSRKASNSKGRKNSTSNKRNSSSSSKRSSSSKNKKSSSSKNKKSSSSKGRKSSSSRGRKASSSKNRKSSKSKDRKSSSSKGRKSSSSSKSNKRKASSSRGRKSSSSKGRKSSKSQERKNSHADTSKQMEDEGQKRRQSSSSAKRDESSKKSRRNSMKEARTKKANNKSASKASKSGSKSKGKSASKSKGKSSSKGKNSKSRSASKPKSNAAQNSNNTHQTADSSENASSTTQTRTRGRQREQKDMVNEKSNSKSSSKGKKNSKSNTRSKSKSKSASKSRKNASKSKKDTTNHGRQTRSKSRSESKSKSEAPNKNSNKMEVIEQPKEESSDRKRRESRSQSAKKTSDKKSKNRSDSKKMTAEDPKKNNAEDSKGKKKSKEGKTGAYGKKANKKQ
What are the official names of this protein?
Micronuclear linker histone polyprotein, MIC LH.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Micronuclei.
Protein: COX15_HUMAN
Sequence: MQRLLFPPLRALKGRQYLPLLAPRAAPRAQCDCIRRPLRPGQYSTISEVALQSGRGTVSLPSKAAERVVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSQEEWEAEFQRYQQFPEFKILNHDMTLTEFKFIWYMEYSHRMWGRLVGLVYILPAAYFWRKGWLSRGMKGRVLALCGLVCFQGLLGWYMVKSGLEEKSDSHDIPRVSQYRLAAHLGSALVLYCASLWTSLSLLLPPHKLPETHQLLQLRRFAHGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESWIPEDLFTFSPILRNVFENPTMVQFDHRILGITSVTAITVLYFLSRRIPLPRRTKMAAVTLLALAYTQVGLGISTLLMYVPTPLAATHQSGSLALLTGALWLMNELRRVPK
What is the function of this protein?
May be involved in the biosynthesis of heme A.
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX15 homolog.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family.
Protein: ISPF_XANC8
Sequence: MSFNFRIGQGYDVHAFGPGDHLMLGGVRMAHSHGVLAHSDGDVVLHALCDAMLGGLALGDIGVHFPPSDARWKGADSAQFVQHCDQLLRDRGWRVGNADITVICERPKVGPHALAMRERIAGLLAIELDAVSVKATTSEKLGFTGRSEGIAAQAAVLLGKIAA
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: ARNT_MOUSE
Sequence: MAATTANPEMTSDVPSLGPTIASGNPGPGIQGGGAVVQRAIKRRSGLDFDDEVEVNTKFLRCDDDQMCNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRVLDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGTSSVDPVSMNRLSFLRNRCRNGLGSVKEGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNICQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIPRSQLGPTANLSLEMGTGQLPSRQQQQQHTELDMVPGRDGLASYNHSQVSVQPVASAGSEHSKPLEKSEGLFAQDRDPRFPEIYPSITADQSKGISSSTVPATQQLFSQGSSFPPNPRPAENFRNSGLTPPVTIVQPSSSAGQILAQISRHSNPAQGSAPTWTSSSRPGFAAQQVPTQATAKTRSSQFGVNNFQTSSSFSAMSLPGAPTASSGTAAYPALPNRGSNFPPETGQTTGQFQARTAEGVGVWPQWQGQQPHHRSSSSEQHVQQTQAQAPSQPEVFQEMLSMLGDQSNTYNNEEFPDLTMFPPFSE
What is the function of this protein?
Required for activity of the AHR.  Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE).  Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding.  The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (By similarity).  The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (PubMed:26245371, PubMed:27782878).  The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820, PubMed:26245371, PubMed:27782878).
What are the official names of this protein?
Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMA_ENTFA
Sequence: MTDYKEIATPSRTKEILKKHGFSFKKSLGQNFLTEPNILRKIVETAGINQQTNVVEVGPGIGALTEQLAMNAAQVVAFEIDDRLIPVLADTLSRYDNVTVVHQDVLKADLVETTNQVFQEKYPIKVVANLPYYITTPIMMHFLESSLDVAEMVVMMQKEVADRIAAKPGTKAYGSLSIAVQYFMEASVAFIVPKTVFVPQPNVDSAIIKLTRRATPAVTVTNEKEFFKLTKASFQLRRKTLWNNLTHFYGKDEQTVAWLKESLAEAEIDPSRRGETLSLEEFARLSNALEKNKPV
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLX5_YEAST
Sequence: MHSDTNGRTKSNNSPSDNNPNETVILIDSDKEEDASIREANLPVRLYPDRRVGRRRDALNRFVRSDSRSRNSQRTHITASSERPDFQANNDDITIIREVGRFFGDDGPIDPSAHYVDLDQEPGSETLETPRTIQVDNTNGYLNDNGNNNESDDGLTIVEERTTRPRVTLNLPGGERLEVTATTTDIPIRRSFEFQEDLGASRRQLLRRSATRARNLFVDRSDENDEDWTDDTHNLPEAIQRARRESRMRMSRRIAERQRRVQQQRVSSDENISTSIRLQSIRERIQSYTPDIRSAFHRAESLHEFRSILQNVAPITLQECEEELMALFTEFRNQLLQNWAIDRVRNTQEEALRLHREALERQERTAGRVFHRGTLRESITNYLNFNGEDGFLSRLWSGPALSDADEERHTQNIIDMIQEREERERDVVMKNLMNKTRAQQEEFEARAASLPEGYSASFDTTPKMKLDITKNGKEETIIVTDDDLAKTLEDIPVCCLCGAELGVGIPDDFTGISQKDRGVSFEGLVSKYKFHCPYQTLARPSMLDRDLSKRTFIASCGHAFCGRCFARIDNAKKKSKMPKKKLAQLKGSAHPDNYGPKLCPADSCKKLIRSRGRLKEVYF
What is the function of this protein?
Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation (PubMed:11139495, PubMed:16325482, PubMed:18032921, PubMed:17669696, PubMed:17848550, PubMed:18499666, PubMed:18948542, PubMed:31015336).  The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins (PubMed:18032921).  The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin (PubMed:26960795).  The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis (PubMed:23785440).  The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins (PubMed:26906737).  During replication, the complex helps prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2 (PubMed:16325482, PubMed:17591698).  The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination (PubMed:30479332).  It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57 (PubMed:18032921).  Along with SIR2, promotes silencing of genes at telomeric or ribosomal DNA (rDNA) loci (PubMed:18086879).  Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets (PubMed:31015336).
What are the official names of this protein?
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5, Hexose metabolism-related protein HEX3, RING-type E3 ubiquitin transferase SLX5, Synthetic lethal of unknown function protein 5.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes to few distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots).