PharMolix/UniProtQA huggingface dataset:
Protein: ACT22_ALTAL
Sequence: MQQPIVGVGHSMGGCQIATLSVTSRRIFSTMILLDPAIGPPEMGLATLGLGQLTLRRRTQWLTREDAEKALRTSFSTWDPQVLDLLIKHSIHSDKQSVEMEDGPVSLVTGRYQELVNYIKPSFIRSGKVVGQELVHQTGPVDMYHMLGLVTCSTLYLCGGESTLSTPRARELWLSRTAELSYSKDPGEMRKVDERIVPDTGHFLPMEEPKECADIIADWIDKDECMIWNCHIGKQGKIWRDLSNTNRKMNAEVWIEYLQSKL
What is the function of this protein?
Abhydrolase domain-containing protein; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) ACT-toxins responsible for brown spot of tangerine disease by the tangerine pathotype which affects tangerines and mandarins (PubMed:18944496, PubMed:18986255).  ACT-toxins consist of three moieties, 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA), valine and a polyketide (PubMed:22846083).  ACT-toxin I is toxic to both citrus and pear; toxin II the 5''-deoxy derivative of ACT-toxin I, is highly toxic to pear and slightly toxic to citrus (PubMed:22846083).  On cellular level, ACT-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The acyl-CoA ligase ACTT1, the hydrolase ACTT2, the enoyl-CoA hydratases ACTT3 and ACTT6, and the acyl-CoA synthetase ACTT5 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) structural moiety (PubMed:18944496, PubMed:18986255, PubMed:19271978).  The exact role of each enzyme, and of additional enzymes identified within the AF-toxin clusters have still to be determined (PubMed:18944496, PubMed:18986255, PubMed:19271978).  On the other hand, ACTTS1 to ACTTS4 are specific to the tangerine pathotype (PubMed:22846083).  The function of ACTTS3 is to elongate the polyketide chain portion of ACT-toxin that is unique to this toxin (PubMed:20192828).  The enoyl-reductase ACTTS2 might complement the missing enoyl-reductase (ER) domain in ACTTS3 in the synthesis of the polyketide portion of ACT-toxin (PubMed:20055645).  The roles of the nonribosomal peptide synthetases-related proteins ACTTS1 and ACTTS4 have also still not been elucidated (PubMed:22846083).
What are the official names of this protein?
Abhydrolase domain-containing protein ACTT2-2, ACT-toxin biosynthesis protein 2-2.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.
What are the subcellular locations of this protein?
Peroxisome. Note=The peroxisomal location requires the C-terminal tripeptide peroxisomal targeting signal.
Protein: 343L_IIV6
Sequence: MELKNMELKRKLTINEINFIVDFIQPRPYIPPDIENAIIFKKKKGIIDQLVTIEIYESLIPKLKEEIEKQYVNSLIDPGECVGIIGAQSMGEYSTQATLNTFHVAGVDTGSSTGVSRFQDLINASKTVKIDNISLFFKPLFVKKNITELRKLVASKLIEVKLSHLMITSVIVKTEEISQYRQEIESCIELYNDEHFNYEDYEFCLKITLSRELLLKHRLHPSVIKNKLEEYNNDCKYAFLPISSQQILFFIFIYVNTDECIEKIIQDLMDKKICGVDGIIRYDFKRKDLFDDEWYIETTGGSFSNINCLADIFDLTKTKTTSIWDLYNTFGIEATKQFLIQELKTVMDGVDICHIKLLVERMTYSGTIEPITRYTMRNDESPLSRASFEESFETFLKAAKFKEIEPFTGVSASVIGGKKTEVGTYMCDILIDMEKLNLGDLKTIEDDDEYDYEDDGDLVYVE
What is the function of this protein?
Component of the DNA-dependent RNA polymerase that catalyzes the transcription in the cytoplasm of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit 343L.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: GPLPC_ARATH
Sequence: MAEGLVLKGIMRAHTDIVTAIATPIDNSDIIVTASRDKSIILWKLTKDDKSYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLATGETTRRFVGHTKDVLSVAFSTDNRQIVSASRDRTIKLWNTLGECKYTISEGDGHKEWVSCVRFSPNTLVPTIVSASWDKTVKVWNLQNCKLRNSLVGHSGYLNTVAVSPDGSLCASGGKDGVILLWDLAEGKKLYSLEAGSIIHSLCFSPNRYWLCAATENSIRIWDLESKSVVEDLKVDLKSEAEKNEGGVGTGNQKKVIYCTSLNWSADGSTLFSGYTDGVVRVWGIGRY
What is the function of this protein?
Minor component of the RACK1 regulatory proteins that play a role in multiple signal transduction pathways.  Involved in multiple hormone responses and developmental processes (PubMed:18947417).  MAPK cascade scaffolding protein involved in the protease IV and ArgC signaling pathway but not the flg22 pathway (PubMed:25731164).
What are the official names of this protein?
Receptor for activated C kinase 1C, Guanine nucleotide-binding protein subunit beta-like protein C.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
Protein: Y1080_BACHK
Sequence: MLYLHDVWVNWFEGEENGYNVCHFYEWRKDDTIELLDQVPLLKVDSTLYHYIENELLELPQKLLEDVHHKAYIRKNHERLQQEYCFVVTDGKGIIAIDTIGYNVPIRKSRLIPRQEQMVYEMVENVQAEKYEFQVEEMEKEHHILSPSPFVMNGLTRKERQLKQLLFMALDQLHTTKNTAEIRYWFTEWDPSAYGMVQHMEFEDIWAKLYDEAKTGWSEKHEQLCERLVKGQPFFEKLWEMENEQKVN
What are the official names of this protein?
UPF0736 protein BT9727_1080.
What is the protein family that this protein belongs to?
Belongs to the UPF0736 family.
Protein: TBB2_LUPAL
Sequence: MREILHIQGGQCGNQIGAKFWEVVCAEHGIDSTGRYEGDNVLQLERVNVYYNEASCGRFVPRAVLMDLEPGTMDSLRSGTYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSTVCDIPPTGLKMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEDGYEYEDEEEVGEEDA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-2 chain, Beta-2-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: QDR3_CANAL
Sequence: MSHSPNLSPQISNDIIDADTTSLASTETQQNIQHSQIHPIGHHGREQSEEPQNTTKTTTTTTNKIHTTTPSVDPDLGPLRELEQDLSSLESQQEQYLSQKPTSTSIKTNKVPLRERRGLLAQIVLIPEYEDARDYPNKIKYLIVFIIAFASLAGPFGTSVMLPAIDDIVNDLNTNVSTVNVSVGIYLLSLGIFPLWWSSFSERFGRRSVYMVSFTLFVAFSIGTALSPNIAALIVLRVLQGGSSASVQAVGAGTIADLFIPQERGQAMGLYYLGPLAGPFLAPILGGAVSQAWGWRATQWLLMIISACSFVLITFFLPETLRRVDTIQVAKDLMKKSDNNGSQNEKIHDDFAGADNSSVHDIDGNPIPGTELHQVVSNLSRRSSNARSIVTYMEEQENEGPIIDPVMPSISRLTTNRSAYSQRIHQNYVTDELRKTTSNLTQSNHSQYNNNNNNDNDKWSSVKTNCYDLIIRPLHSIILLKHPPVVLVISFSAISFAAIYFFNMAISYEYARSPYNFSSVILGLMYIPNSVTYFMASIIGGKWNDRLLNRYAQKHGELVPESRLSWNIVVAIILYPMACLIFGWTIKYREFWVIPLIGTALFGFASMLVIGATVTYLVDSLPGKGATGVALNNLIRQILAAIATFIVEPLLRAIGAGVLFSIIAGILLVSSLVLLYLKKRGAFFREHYDVMDLYAKL
What is the function of this protein?
MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence.  No substrate for transport has been identified yet, but plays an important role in the growth in the host.
What are the official names of this protein?
MFS antiporter QDR3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. CAR1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=In contrast to QDR1 and QDR2, does not accumulate in membrane rafts and shows uniform distribution at the cell membrane.
Protein: ARAC_ECO57
Sequence: MAEAQNDPLLPGYSFNAHLVAGLTPIEANGYLDFFIDRPLGMKGYILNLTIRGQGVVKNQGREFVCRPGDILLFPPGEIHHYGRHPEAREWYHQWVYFRPRAYWHEWLNWPSIFANTGFFRPDEAHQPHFSDLFGQIINAGQGEGRYSELLAINLLEQLLLRRMEAINESLHPPMDNRVREACQYISDHLADSNFDIASVAQHVCLSPSRLSHLFRQQLGISVLSWREDQRISQAKLLLSTTRMPIATVGRNVGFDDQLYFSRVFKKCTGASPSEFRAGCEEKVNDVAVKLS
What is the function of this protein?
Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose.
What are the official names of this protein?
Arabinose operon regulatory protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOZJ_BACSU
Sequence: MADRYVLIEVNEDGEGRLKDEAVTWIDFRLSIVDFNASEGLNQLMEQISKDVKDELVLVLFNYRVKSSYDSWSGATEYEDFFDVEFFKVIKKNYKKFYQGLVTVELDVGINGFDNIESMPTDSNQNYYRNLIAEWEEFYNEDFIPLSLNKR
What are the official names of this protein?
Uncharacterized protein YozJ.
Protein: CLPX_ECO8A
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRNHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVISHRVETGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIDGQSKPLLIYGKPEAQQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SYL_METMA
Sequence: MEQDYKPHEIENKWQKKWNESRIFQAEPDKREKFFITIPYPYLNGNLHAGHTRTFTIGDVVARHKRMLGYNVLYPMGFHVTGTPIVGLAELIASRDPQTMDVYERLHGIPGDILPALDTPEKIVDYFKVEAEKAMRMIGYSIDWRRKFTTTDPTYKKFIEWQYTRLEEKDLIVKGSHPVKWCPNDNNPVEDHDILHGEEATIVEYTLIKFRYRDLVLPCATLRPETTYGVTNLWVNPNVDYVKARVEKDGNVEFWVVSRDAFRKLTFTDRTVEYVEDMPAKSIIGIKLTNPVTGDEVISLPASFVKPENGSGIVMSVPAHAPFDYLALRDLYDADLSEYGITEDLRKIELISLIQVPEFGEFPAKEIVESMGISDQKDPKAEEATKIVYRREFHGGVLKELTGKYKGYPVSKIKDILTRDFLASNAGETFYEFSEPVVCRCGTPCVVNMVKGQWFLNYSNPDWKAKVYKCLGQMRVIPTEYRVEFENKIDWLKDKACARRKGLGTRLPFDKEWLIESLGDSTIYMSYYIIARFIEKGELALEHLTLSFFDYVLLGKGDSAAVSAETGLKPELIEEIRSHFNYWYPVDLRSSGKDLVPNHLLFFLFHHVALFEEEKWPKALAVNGFVSLEGQKMSKSKGPILTLESAVSSYGADITRMYILSTAEQTQDADWQKAGIDSARRQVDRFYAFAKDVIESGKRGTLSAELKQIDRWMLSRMQNYIKETNAALDSIQTREAIQNSFFLLINDVRWYQRRGGEALLYYVLDNWVRLMAPFTPHLCEEVWEAMGHEDPVSLAQYPLYNEDLIDNGAELSEEAVKSTLNDIEEIIRVTKMTPQKVYLYTAPAWKAEAIRCACGLQVEAPLEVGTLIKTLMAKPELKRFGKEIPKFVQKIVPEFKSGGAERYETFAYLGLDEKDLLKESASFLEKEIGCPVEIQSADSPEYDPQKKSRFAEPLRPAIYIEEKKEE
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U587_NEMVE
Sequence: MVRIGLQLKANLENVTNLKAEGEDFRWYLMLKCMNCGEVTKQWVYMCLMESQPVKGGRGYAHFVSKCKLCHRENSVDIMKDSIHPYLASHNGKFHTIVSFDCRGVEPTDFSPRTGWTAEGENTSTPFEVDLTEKDWSDYDEKAQNAVGVYGVTSQFIKL
What are the official names of this protein?
UPF0587 protein v1g245604.
What is the protein family that this protein belongs to?
Belongs to the UPF0587 family.
Protein: RL16_RHIME
Sequence: MLQPKRTKYRKQFKGRIKGVAKGGSDLAFGEFGLKAQEPNRVNAREIEAARRAITRHMKRAGRVWIRVFPDVPVTAKPTEVRMGKGKGSVEYWACKVKPGRMMFEIDGVNEELAREALRLGAAKLSVKTRFVQRIAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: BIOB_VIBA3
Sequence: MEVRHDWTVAEVRALLEKPFMDLMFEAQVVHRQYQEHNHVQVSTLLSIKTGACPEDCKYCPQSAHYRTDVDKERLMEVERVLDAAQKAKNAGSTRFCMGAAWKNPKERDMPHLTDMIKGVKGMGLETCMTLGMLTPDQAGELADAGLDYYNHNLDTSPEFYGSIITTRTYQDRLDTLSHVRDAGMKICSGGIIGMGESTNDRAGLLVELANLPVHPESVPINMLVKVKGTPMENVDDVESFDFVKLIAIARIMMPMSAVRLSAGRENMNEQMQAMCFMAGANSIFYGCKLLTTPNPDEDTDMQLFKKLGINSQQVAQKPDEIQENELLDQVVERVAARPTKDDMFYDATV
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: DMS5_PHAJA
Sequence: GLWSKIKEAGKAAVKAAGKAALGAVANSV
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Dermaseptin-J5, DRS-J5.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HRCA_PELTS
Sequence: MKLDDRKQKVLLAIVHDYIATAEPVGSRTIAKKYKLGVSPATIRNEMADLEEMGYIEQPHTSAGRIPSERGYRYYVDYLMKRQELSREEEELIRREYEAKVRDVGQVIQKTGQLLSQLTNYTAVVLSPQIESSRFKYIQLVSMHPSQAMVIVVMDNGIVHNRMIEVPESITCADMETISRVLNAKLRGLTMESIRLTLMKEIYFELARHKHILDLAMELIQDSLLHKVEDKIYLGGVFNMLNQPEFHDVEKVKTLLGILEQEKLLRDLITSGGSEEGVTVRIGGEIMHEDIRECSMVTAPYSVCGRKIGSLGVLGPTRMEYAKVVSVVDFMTKNLSQVLERIVRGTGR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: RL16_LEPBA
Sequence: MLAPKRVKFRKRQRGRLKGKDERGSYVAFGEFGLKAISSGRITARQIEAARITINRQVKRGGKLWIRIFPHLPITKKPAETRMGKGKGNPEFWIAEIRPGRVLFEMAGVDEETARKALHLAAFKLPVETSFVKRNVL
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: 94D19_PARPY
Sequence: MESLSLIFISFITLIVFLVVSASKKRSHPSGYEPDIPKGGCPMLDSTAYLVLSSPTNTAVTSTGIITSNPENIEHVLKTNFANYPKGEHLTYGLYDLLGRGIFNSDGDHWKLQRKIASLEFNTRTIRHFVTHDVSREVLDRLLPSLSRAANSGEIIDLQEVLDRLAFDNVCKIAFDDDPARLADKKFNDGENDYYGKFAKAFGEAAEISTQRFEKSRWKIARALNLGTERKMKNALAIVNEFAMQVVREMKRKRAEEGKGRGSSADLLSLFISEGEFSDEFLRDVVISFVLAGRDTTSSTMAFFFWQVSTRPSICQKIKEEIVSVRKNHNNSQGGAFTLEELREMDYLHAVLSETLRLYPIVPLHARYTLADDVLPDGTMVKKGSTVMHSIYAMGRMESIWGADCLEFRPERWLENGVFRPKSPFLFPVFLAGPRMCLGKETAYMQMKAVAASVMEKFKIEVADGKHESEREYYLEIVLRLKGGLPVRVTEKEWSDNSAVNV
What is the function of this protein?
Involved in the biosynthesis of spiroketal steroid and saponin natural products from cholesterol such as diosgenin and analogs (e. g.  furostanol and spirostanol), plant defense compounds used as main precursors for the industrial production of steroid hormones (PubMed:31324795).  During the 5,6-spiroketalization of cholesterol, may catalyze the 27-monohydroxylation of furostanol-type steroid to an intermediate product that undergoes a stereospecific formation of the terminal heterocycle to yield diosgenin (PubMed:31324795).
What are the official names of this protein?
Cytochrome P450 CYP94D109, PpCYP94D109.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: RL11_COXB1
Sequence: MAKKITGYIRLQIKAGEANPSPPVGPALGQHGVNIREFCESFNTATKNIEKGLPTPVIITVYADRTFSFITKTPPASVLLKKFVLKGKSGSARPNTEKVGKATRQQLEEIAKMKTPDLTAADLEAAIRTIAGTARSMGIDVEGVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: COAA_RHOPT
Sequence: MDARSDLHHYNPYRVFSRAEWASMREDTPMTLDAAEVAALRSMHDRLDLSEVEEIYLPMSRLLSIHVAAMQQLYYAQRRFLGVVERKMPFIIGVAGSVAVGKSTTARVLQALLARWSPRPTVDLVTTDGFLHPNAVLERAGLMQKKGFPESYDLPALLGFLSDIKSGRRKVKAPIYSHLTYDIVPNKFTVIDRPDILIVEGVNVLQTGRLPRDGKAVPVVSDFFDFSVYLDADEPVLRDWYVRRFLALRDTAFHDPRSYFHRYAVLSDEEATATAIAIWERTNLANLEDNILPTRPRATLILKKGADHVVDSVALRRL
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_MANSM
Sequence: MIDLHNIRNEYSQQALSEKQCDDDPLKQLEKWLNEAIQAKVNEPTAMNVATVGENGKPSSRVVLLKEVNERGLVFFTNYHSHKGRDLAVNPFAAVNLFWAELQRQVRVEGRVERISPQASDEYFASRPYTSRIGAWASEQSAVISGKNSLLTKAALIAAKHPLQVPRPPHWGGYIVIPELIEFWQGRPSRLHDRIRYRLEKGEWVRERLSP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: LAP4B_MACFA
Sequence: MKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLIINAVVLLILLSALADPDQYHFSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNTLVAITVLVYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPYVSA
What is the function of this protein?
Required for optimal lysosomal function.  Blocks EGF-stimulated EGFR intraluminal sorting and degradation.  Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation.  Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation.  Plays a role as negative regulator of TGFB1 production in regulatory T cells.  Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.
What are the official names of this protein?
Lysosomal-associated transmembrane protein 4B.
What is the protein family that this protein belongs to?
Belongs to the LAPTM4/LAPTM5 transporter family.
What are the subcellular locations of this protein?
Endomembrane system; Multi-pass membrane protein. Late endosome membrane. Cell membrane. Cell projection. Lysosome membrane. Endosome membrane. Endosome, multivesicular body membrane. Endosome, multivesicular body lumen.
Protein: DAPAT_SYNJA
Sequence: MARINDHFLKLKAGYLFPEIARRVQAFAAAHPEAQIIKMGIGDVTEPLPEACRTAMIRAVEEMGERATFRGYGPEQGYEWLRQAIARHDFQARGCDIDASEIFISDGSKCDCGNILDILGHDNTIAITDPVYPVYVDTNVMAGHTGPANERGEYEGLVYLPLTAENHFTASLPQQKVDVIYLCFPNNPTGAVATREHLQAWVDYARAHNSLILFDAAYEAYITEPGIPHSIYEIPGARECAIEFRSFSKTAGFTGTRCAFTVVPKSLRGQAADGSWVDLWSLWYRRQSTKFNGVAYIVQRGAEAVYSEAGQVQVRALVQFYLENARIIREQLATAGIQAYGGVNAPYVWVKAPEGLSSWEFFDKLLHTCHVVGTPGSGFGSAGEGYLRLSAFNSRANVEEAMRRIVSVFGS
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: QUEA_THEMA
Sequence: MKVSEFDYELPPELIAQEPVEPRDASRLMVLHRKTQRIEHRIFREIIEYLEPGDLLVLNVSKVIPARLYARKKTGASIEILLIERLEEGIWKCLVRPGQKVKKGTELVIDEDLSAVCLGRGEDGTRILKFQPQDDRLIFEKGRTPLPPYIKNEVPLERYQTVYAKEEGSVAAPTAGLHFTPELIEKLKKKGVQFAEVVLHVGIGTFRPVKVEEVEKHKMHEEFYQVPKETVRKLRETRERGNRIVAVGTTTVRTLETIARLPEQEEYVGKTDLFIYPPFEFKLVDALVTNFHLPRSTLLMLVAAFAGKDFVMEAYREAVKRRYRFFSFGDAMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PALF_EMENI
Sequence: MVRATCSCVMSVNPLSAQTSASPLSRNRSSLLSKFRTQLGQRNRAITDFYIEPDDPWRSYFPGDVIKGTVSLTVVRPVRITHLVISLHGIVKVFKNNVPAGETPPDVGSLGPGRGRRGAEYLGNGVATLFEDEVVLCGEGRLKEGIYKFRFEMSFPPYPLPSSISFERGTISYMLTSTLTKPTTMNPTLSCRRRINLLENIDIAAFPAPKPRVVTLEPISKRSKPKGKTKAAGFDAPDTASLEPSASGGITVPEHRPPLSPAPSNVSSSSRLSNSSQSFQIVTDPGSTASSGVRNSEARSNTPSVTDGIITAKAEVLRAGVLPGDTLPIKITINHTKQVRSAHGIIITLYRSGRIDLHPAIPMGSTANGKKPIYEDYYPRSRTGLGGLTLGTSRASSVFRKDLSQTFAPLIVDPTTLTADIKTSIRIPEDAFPTITRTPGSMINFRYYVEVVVDLRGKLTSPERFLPRFNLVSSGRNFSSNGKIVHPADTNGSAITANWGDNILDTDQIRREKGVVAVIFEVVIGTQDTQRRKSEARRMSSTAEEAEFQQPVENSVDGDYAGHDYQGSMAGPEPGYAPLENTAYGPDQIRWPDYPEQSEHEHYPFQPGTLPSPQPDEPMDEKARLRRAEQTLLPSQPPCDPEAGPSSAVEAAMPTAPVLPEDDHLNDYHHLPSTTVNGMTGMAPALMSAESVQTVIAGSSSAPLTSPSRPSEEDKQELERQRLMMEASAPGDPDARHNDRADDGPSAPIFHDDDDDQQLVGGAANGDELLPRYQR
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH.
What are the official names of this protein?
pH-response regulator protein palF/RIM8.
What is the protein family that this protein belongs to?
Belongs to the arrestin family. PalF/RIM8 subfamily.
Protein: TSC1_RAT
Sequence: MAQLANIGELLSMLDSSTLGVRDDVTTIFKESLNSERGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKHLLDKMNEYVGKAATRLSILSLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENVETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKTLETHDVVIECAKISLDPTEASYEDGDAVSHQLSACFPHRSADVTTSSYVDTQNSYGGATSTPSSTSRLMLFSTPGQLPQSLSSLSTRPLPEPLQASLWSPSAVCGMTTPPTSPGNVPADLSHPYSKAFGTTTGGKGTPSGTPATSPPPAPPCPQDDCAHGPASQASATPPRKEERADSSRPYLPRQQDVPSDRGLEDLPGSKGSVTLRNLPDFLGDLASEEDSIEKDKEEAAISKELSEITTAEADPVAPRGGFDSPFYRDSLSGSQRKTHSAASGTQGFSVNPEPLHSSLDKHGPDTPKQAFTPIDPPSGSADASPAGDRDRQTSLETSILTPSPCKIPPQRGVSFGSGQLPPYDHLFEVALPKTACHFVSKKTEELLKKAKGNPEEDCVPSTSPMEVLDRLLEQGAGAHSKELSRLSLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYSQLQQQRDTMVTQLHSQIRQLQHDREEFYNQSQELQTKLEDCRSMIAELRVELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQSKHPDTTKEVEMMKTAYRKELEKNRSHLLQQNQRLDASQRRVLELESLLAKKDHLLLEQKKYLEDVKSQASGQLLAAESRYEAQRKITRVLELEILDLYGRLEKDGRLQKLEEDRAEAAEAAEERLDCCTDGCSDSLLGHNEEAAGHNGETRTSRPGGTRASCGGRVTGGSSSSSSELSTPEKPPNQRFSSRWEPTMGEPSSSIPTTVGSLPSSKSFLGMKTRELFRNKSESQCDEDGMTMSSFSETLKTELGKDSAGMENKTPPSLDAPHPSSPSSDSMGQLHIMDYNETHHEHS
What is the function of this protein?
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity).  Implicated as a tumor suppressor.  Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (PubMed:16707451).  Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (By similarity).  Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (By similarity).  Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity).  Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity).
What are the official names of this protein?
Hamartin, Tuberous sclerosis 1 protein homolog.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Protein: LPXC_LEPBA
Sequence: MQTVIHRKTIQNSVTLKGIGVHSGKVVTLRLHPAEANTGLIFYLYKGIQKIRIPVSLDHVVDTSNATTIGDGSSNRVQTIEHLLAAVHTLGITDCIFEIDSVEVPIMDGSSLPFWEGIRSAGIRVLEETIEPITITNPIWVVDGDKYLVMLPSDELKVTYSIDFNHPLLRGQSYTTTLDESILGTDILPARTFGFLKDVEALQARGLAMGGSLDNAVVLTDDGYLNDHLRYDNECVRHKILDLVGDLAVMGRPFRGHLIASKAGHALDISLAKCIMSQVTGNELTQYKSKRIPLFSKKEAAK
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.