PharMolix/UniProtQA huggingface dataset:
Protein: RRP4_METS3
Sequence: MIYVENKDLVIPGEVLADDEYYSGRGTFKENGKICSSLMGLVSLRNKKIRVIPLKSKYVPKKGDVVIGKIKDVRFSMWDVDINSPYSGILPAFEVFGREKKELNKVFDVGDVLFLRVVDVDEVKKVKLGLKGRGMGKFRGGIIVDITPTKVPRLIGKKGSMINMIKDKTNCKIIVGQNGLVWVKGEEDMEQLTKDIIHMIEAEAHTSGLTNKVKNKLSLAIDGELPQEDDYSDDYEELEKPKLQNFKEELEQEEKEEQSKKDSTDFYKVIEELKKKNKKDKPLSYGNNSGNSYILNNR
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Increases the RNA binding and the efficiency of RNA degradation.  Confers strong poly(A) specificity to the exosome.
What are the official names of this protein?
Exosome complex component Rrp4.
What is the protein family that this protein belongs to?
Belongs to the RRP4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SK1_DERIN
Sequence: EQFDDYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-1, DerIn-SK-1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP6_HAES1
Sequence: MAGHTTADYISHHLTFLTTGQGFWNVHLDTLFFSLVSGVLFLFFFYRTASKATSGVPGKFQCLVEMLVEWVDGVVKDNIHGSDVRHQIGSLALTIFCWVFVMNAIDLIPVDFPPQFAELLGIHYLRAVPTADISATLGMSVCVFALIIFYTIKSKGLGGFVKEYTLHPFNHWAFIPVNFLLEAVTLLAKPISLAFRLFGNMYAGELIFVLIAVMYMADNIIPQVLGIPLHLIWAIFHILVITLQAFIFMMLTVVYLSIAYNKSDH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MARH6_MOUSE
Sequence: MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPVGGNGAENPAADQPANPAGENAVLGENPDAQDGQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHALATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSLLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQPARNNNAVPAGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVLVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIIRKLAAPVISVLLLSLCVPYVIASGAVPLLGVTAEMQNLVHRRIYPFLLMVVVLMGILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGPSTPPPVSSQE
What is the function of this protein?
E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation.  Promotes ubiquitination of DIO2, leading to its degradation.  Promotes ubiquitination of SQLE, leading to its degradation.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.  May cooperate with UBE2G1.
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF6, Membrane-associated RING finger protein 6, Membrane-associated RING-CH protein VI, MARCH-VI, RING-type E3 ubiquitin transferase MARCHF6.
What is the protein family that this protein belongs to?
Belongs to the DOA10/MARCHF6 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PPAP_BOVIN
Sequence: MRNAALLMTRATSLRLSLLLLLSFLPDLDGGVRAKELRFVTLVFRHGDRSPIETFPNDPIKESSWPQGFGQLTQLGMAQHYELGQYIRKRYENFLNESYKREQVHVRSTDIDRTLMSAMTNLAALFPPEGISIWNPSLPWQPIPVHTVPVSEDQLLYLPFRNCPRFQELQSETLISEEFQKRLQPYKDFIEVLPKLTGYHDQDLLGIWSKVYDPLFCEGVHNFTLPSWATEDTMTKLKEISELSLLSLYGIHKQKEKSRLQGGVLINEILNHMKSATQPSNRRKLIMYSAHDTTVSGLQMALDVYNGILPPYASCHMMELYFQDGEYFVEMYYRNETRYEPHPLTLPGCTPSCPLAKFVELVAPVISQDWSMECAIRNHKGTEDIIN
What is the function of this protein?
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins.  Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity).
What are the official names of this protein?
Prostatic acid phosphatase, Protein tyrosine phosphatase ACP3.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1469_SODGM
Sequence: MTKTVLLYIATAVAAILGCYLPYCYVKRDGSLLLIPAALSLIAFVGLLVLYPAASGRVYAAYGGVYILTAFLWLRFIDGIKLSPPGLSGRGGGIVRGRDHDRRLAPRRGLRGAESGVDLAGFACGCPTRRSH
What are the official names of this protein?
UPF0060 membrane protein SG1469.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF1_GRAFK
Sequence: MAKQAAIEQDGTIIEALSNAMFRVELENGHVVTAHISGKMRMHYIKLLPGDKVKLEMSPYDLTKARITYRY
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORSC_EMENI
Sequence: MLAFNPLVTALAALIFLFCQANANPPLMQRLVHEYQWKTKQGLPRQGACTPHNLAVRREWSTLDVETRLEYIEAVKCLARLPSIIDPELAPGARSRFDDFQATHIRHTRTIHATGSFFAWHRHFVYLYEKALREECGYTGYQPYWEWSHWANLPITANPLYDGSNASLSGNGVYIPNRNGTLQLFPIPNPSPDTAIYTPPGTGGGYIYDGPLVDWELHLGPVLYSYDNGQYIPPNPRPDGLGYNPRPLIRDFNNTLLQQGASWDIILNMLVNVTDMHEFHPLFFQGPHLAGHIFISGVDNDIFTSPGDPLFWFHHAQVDRIWTIWQALDLETREYALDGTLTLLNCKNLPFRRILAGELTVCDDSTAQP
What is the function of this protein?
Tyrosinase-like protein; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B (PubMed:19666480, PubMed:20174687).  The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:19666480, PubMed:20174687).  Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B (PubMed:20174687).  The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B (PubMed:20174687).
What are the official names of this protein?
Tyrosinase-like protein orsC, Orsellinic acid/F9775 biosynthesis cluster protein C.
Protein: SYDND_BACSU
Sequence: MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRTGIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGVNVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDENGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQIARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPRMTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAGDYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGDLLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAAHHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGFSPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCLMTEAPGEVSDAQLDELHLSIKKKVKN
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_CERS4
Sequence: MNAPHRDDGFFTESLSSRDPELFASITGELGRQRDEIELIASENIVSRAVMEAQGSVMTNKYAEGYAGKRYYGGCDYVDVAETLAIERAKQLFGCAYVNVQPNSGSQANQGVFQALIKPGDTILGMELASGGHLTHGAAPNQSGKWFNAIQYGVRQQDQLIDYDQVAALAREHKPKLIIAGGSAIPRQIDFARFRAIADEVGALLMVDMAHFAGLVAGGAHPSPFPHADVATTTTHKTLRGPRGGMILTNSEEIAKKVNSAIFPGIQGGPLMHVIAAKAVAFGEALRPEFKAYAAQVVKNAQALADELMKGGLDIVTGGTDTHLMLVDLRPKGVKGNATEKALGRAHITCNKNGIPFDPEKPTVTSGVRLGTPAGTTRGFGEAEFREIGRLIVEVVDGLAANGEEGNAAVEEAVKAKVAALCARFPLYPTL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPC29_YEAST
Sequence: MDYSNFGNSASKKFQDDTLNRVRKEHEEALKKLREENFSSNTSELGNKKHYRAQERMSSPLHRLSPTGKSDDRKVKSPLDDKLRRQLREGNTRLPPPPFSSYGMPPTNRSNLDRIRRRTSSPVRTDKFASQNVIDDQRLEIKYLERIVYDQGTVIDNLTSRITRLESFILNSISDRGDKNFASLEHSRSFSGFPTNKTYGLQMGGLYENDMPYRRSSDNINKEGAREDRSSQIHIENESTEDILKILSSSFHN
What is the function of this protein?
Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.  Links the central plaque component SPC42 to the inner plaque component SPC110.
What are the official names of this protein?
Spindle pole component 29.
What is the protein family that this protein belongs to?
Belongs to the SPC29 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: ATPA_PROMS
Sequence: MVSIRPDEISSILKQQITDYDQSVSVSNVGTVLQIGDGIARIYGLDQVMAGELLEFEDGTEGIALNLEDDNVGAVLMGEALGVQEGSNVKSTGKIASVPVGEAMQGRVVNPLGQPIDGKGEIPTSDTRLIEEMAPGIIKRRSVHEPMQTGITSIDAMIPVGRGQRELIIGDRQTGKSAIAIDTIINQKGQDVVCVYVAIGQKSASVANIVEVLRERGALDYTVVVSAGASEPAALQYLAPYTGAAIAEHFMYQGKATLVIYDDLTKQAQAYRQMSLLLKRPPGREAYPGDVFYLHSRLLERAAKLSDAMGGGSMTALPIIETQAGDVSAYIPTNVISITDGQIFLSADLFNSGLRPAINVGISVSRVGGAAQTKAIKKIAGTLKLELAQFDELAAFSQFASDLDEATQQQLERGKRLRELLKQPQFSPLNLAEQVAVVYAGVKGLIDEVPVEDVTKFATELREYLKLNKSEFIEEILKEKKLNDGLEATLKEVINEVKSSMLATV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: RL33_PARDP
Sequence: MAKPTTIKIRLNSTAGTGHFYVTKKNARTMTEKMTVNKYDPVVRKHVEYKEGKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: ACUA_BACLD
Sequence: MEHHKTYHAKELQTEKGSVLIEGPISPEKLAEYEFHDELTAFRPSQKQHEALIEIAGLPEGRIIIARFRQTIVGYVTYVYPDPLERWSEGNMENLIELGAIEVIPAFRGHSVGKTLLAVSMMDPQMEKYIIITTEYYWHWDLKGTNKDVWEYRKMMEKMMNAGGLVWFATDDPEISSHPANCLMARIGKEVSQESIERFDRLRFHNRFMY
What is the function of this protein?
Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol.  Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue.
What are the official names of this protein?
Acetoin utilization protein AcuA, Acetoin dehydrogenase, Protein acetyltransferase AcuA.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: PFKA2_LACLL
Sequence: MKRIAVLTSGGDAPGMNAAIRAVVRKAISEGIEVYGINHGYAGMVAGDIFPLTSASVGDKIGRGGTFLYSARYPEFAQVEGQLAGIEQLKKFGIEGVVVIGGDGSYHGAMRLTEHGFPAVGLPGTIDNDIVGTDFTIGFDTAVSTVVDALDKIRDTSSSHNRTFVVEVMGRNAGDIALNAGIAAGADDICIPEKEFKFENVVNNINKGYEKGKNHHIIVLAEGVMTGEEFATKLKEAGYKGDLRVSVLGHIQRGGSPTARDRVLASRMGARAVELLRDGIGGVAVGIRNEELVESPILGTAEEGALFSLTTEGGIKVNNPHKAGLELYRLNSALNNLNLN
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP51_MYCVP
Sequence: MTAVKEVPRVSGGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEHMKGHATTIEAEVRKMIEGWGESGEIDLLEFFAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVMHGRIANPPKDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSWTLIELLRHPEFYAKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDFPNPDDFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEMAQPPESYQNDHSKMVVQLARPAKVRYRRRVRD
What is the function of this protein?
Sterol 14alpha-demethylase whose physiological substrate is not known.  Accepts electrons from the iron-sulfur ferredoxin Fdx encoded by an adjacent gene.  In vitro, catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol, to produce the 8,14-dienes stereoselectively.
What are the official names of this protein?
Sterol 14alpha-demethylase, CYPLI, Cytochrome P450 51, Cytochrome P450-14DM, Cytochrome P450-LIA1, Sterol 14-alpha demethylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXB6A_DANRE
Sequence: MSSYFLNSTFPVTLPGGQESFLGQIPLYSSGYTDPLRHYPGAAYGGSSVQEKAYPSSFYQQANGAYSRATAAGPCDYATASFYREKDPACALASIEEHSFVLSQDHRKTDCTGSTGKSIYPEADEQKPSAPVYPWMQRMNSCNGTFGNAGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKLINCSQTSGEEEEEKRTE
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-B6a, Hox-B6, Homeobox protein Zf-22.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PKHUO_HUMAN
Sequence: MASRGALRRCLSPGLPRLLHLSRGLA
What is the function of this protein?
Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF (PubMed:19797084, PubMed:34593629).  Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner (PubMed:19797084, PubMed:34593629).  In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ (PubMed:34593629).
What are the official names of this protein?
PRKCH upstream open reading frame 2, uORF2, Protein uPEP2.
Protein: PDXH_ERWT9
Sequence: MTDSDRLQQIAHLRREYTRGGLRRKDLPEDPLNLFEQWLDQAVAAGLPDPTAMSVATVDEHGQPYQRIVLLKHFDRRGMVFYTNLGSRKAQQLEKNPRISLLFPWHMLERQVMVLGSVERLSTLEVLKYFHSRPRDSQLGAWVSKQSSRISARGVLESKFLELKQKFMQGEIPLPSFWGGYRINIESMEFWQGGAHRLHDRFFYQREGDAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: PGLRB_EMENI
Sequence: MHFLQNSLIAAAMGAALVAAAPAADLDARSSCTFTSASAAKSGASKCSTVTLKSIQVPAGETLDLTGLKSGATVIFEGETTFGYKEWKGPLISMSGDKITVKQASGAKINCDGARWWDTKGSNGGKTKPKFFSAHKLNNSKIQGLKIYNTPVQGFSIQSDHLTISDVTIDNSAGTSKGHNTDAFDIGSSTYITIDGATVYNQDDCIAINSGEHITFTNGYCSGGHGLSIGSVGGRSDNTVKSVTISNSKVVDSQNGVRIKTVYKATGSVTDVTFQDIELSGITKYGLIVEQDYENGSPTGTPTNGVEVEDITFKKITGSVDSSATRVNILCGSGSCKDWTWSGVDITGGKKSSKCKNVPSGASC
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.  Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.
What are the official names of this protein?
Endopolygalacturonase B, Pectinase B, Polygalacturonase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YIDC_PSEPG
Sequence: MDIKRTILIAALAVVSYVMVLKWNDDYGQAALPTQNTAASTVAPGLPDGVPAGNNGASADVPSANAESSPAELAPVALSKDLIRVKTDVLELAIDPVGGDIVQLNLPKYPRRQDHPDIPFQLFDNGGERVYLAQSGLTGANGPDARASGRPLYAAEQKSYQLADGQEQLVVDLKFSDNGVNYIKRFSFKRGEYDLNVSYLIDNQSGQAWSGNMFAQLKRDASGDPSSSTATGTATYLGAALWTASEPYKKVSMKDIDKGGLKENVSGGWVAWLQHYFVTAWIPAKSDNNVVQTRKDSQGNYIIGYTGPVISVPAGGKVETSAMLYAGPKIQSKLKELSPGLELTVDYGFLWFIAQPIFWLLQHIHSLLGNWGWSIIVLTMLIKGLFFPLSAASYRSMARMRAVAPKLAALKERFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWMLWITDLSIKDPFFILPIIMGATMFIQQRLNPTPPDPMQAKVMKMMPIIFTFFFLWFPAGLVLYWVVNNCLSISQQWYITRRIEAATKKAAA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BH087_ARATH
Sequence: MEGLESVYAQAMYGMTRESKIMEHQGSDLIWGGNELMARELCSSSSYHHQLINPNLSSCFMSDLGVLGEIQQQQHVGNRASSIDPSSLDCLLSATSNSNNTSTEDDEGISVLFSDCQTLWSFGGVSSAESENREITTETTTTIKPKPLKRNRGGDGGTTETTTTTTKPKSLKRNRGDETGSHFSLVHPQDDSEKGGFKLIYDENQSKSKKPRTEKERGGSSNISFQHSTCLSDNVEPDAEAIAQMKEMIYRAAAFRPVNFGLEIVEKPKRKNVKISTDPQTVAARQRRERISEKIRVLQTLVPGGTKMDTASMLDEAANYLKFLRAQVKALENLRPKLDQTNLSFSSAPTSFPLFHPSFLPLQNPNQIHHPEC
What are the official names of this protein?
Transcription factor bHLH87, Basic helix-loop-helix protein 87, AtbHLH87, bHLH 87, Transcription factor EN 121, bHLH transcription factor bHLH087.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL28_PARMW
Sequence: MSRVCQLTGTRANNGMAVSHSHIRTKKLQQANLQNRRLWWAEGKRWVNLRVTTRALKTIQKKGLGPYAKSLGINLAKL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: MUL1_MACFA
Sequence: MENGGRPSLCQFILLGTTSVVTAALYSVYRQKAWVSQELKGAKKVHLGEDLKSILSEAPGKCVPYAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQRTNTVPFDLVPHEDGVDVAVRVLKPLDSVDLGLEAVYEKFHPSIQSFTDVIGHYISGERPKGIQETEEMLKVGATLTGVGELVLDNNSVRLQPPKQGMQYYLSSQDFDSLLQRQESSVRLWKVLALVFGFATCATLFFILRKQYLQRQERLRLKQMQEEFQEHEAQLLSRAKPEDRESLKSACVVCLSSFKSCVFLECGHVCSCTECYRALPEPKKCPICRQAITRVIPLYNS
What is the function of this protein?
Exhibits weak E3 ubiquitin-protein ligase activity.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.  Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation.  Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion.  Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations.  Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization.  Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway.  May also be involved in the sumoylation of the membrane fission protein DNM1L.  Inhibits cell growth.  When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis.  Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (By similarity).  Can mediate RIGI sumoylation and disrupt its polyubiquitination (By similarity).
What are the official names of this protein?
Mitochondrial ubiquitin ligase activator of NFKB 1, E3 ubiquitin-protein ligase MUL1, Protein Hades, RING-type E3 ubiquitin transferase NFKB 1.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note=Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.
Protein: RBL_CORSA
Sequence: DILAAFRVTPQPGVPPEEAGXAVAAESSTGTWXTVWTDGLTSLDRYKGRCYKIEPIAGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALXALRLEDLRIPVAYVKTFQGPXHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLSATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGXXFRVLXKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVXHMPALTEIFGDDSVLQFGGGTLGHPWGNRPGAVANRVALEACVQARNEGRDLASEGNEIIREATKWSPELAAACEVWKEIKFEFQAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL2_THEYD
Sequence: MGIRRCKPTSAGRRFVTYHDFSEITKDEPYKPLTTCIKKRKGRNNQGRITSWLKGGGNRKLYRIIDFKRNKHGIPAKIESIQYDPNRSARIALLKYMDGEYRYILAPDGLKVGDTIMSGSGIDIKVGNALPLKEIPLGTMIHNIELFPNGGGKLVRSAGTAAQLMAKEGKYAHVKLPSGEVRLINVNCFATIGQVSNLEHENVIIGKAGRTRHMGRRPSVRGVAMNPIDHPLGGGEGKSSGGRAACTPWGKPEGVKTRKNKRTDKFIIKRRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.