PharMolix/UniProtQA huggingface dataset:
Protein: RL17_STRR6
Sequence: MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTVEKMITLGKRGDLHARRQAAAFVRNEIASENYDEATDKYTSTTALQKLFSEIAPRYAERNGGYTRILKTEPRRGDAAPMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: DDX10_HUMAN
Sequence: MGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYSTPATLEQNYIVCELQQKISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQKKVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRSVYLMKDKEVFDVSKLPIPEYALSLGLAVAPRVRFLQKMQKQPTKELVRSQADKVIEPRAPSLTNDEVEEFRAYFNEKMSILQKGGKRLEGTEHRQDNDTGNEEQEEEEDDEEEMEEKLAKAKGSQAPSLPNTSEAQKIKEVPTQFLDRDEEEEDADFLKVKRHNVFGLDLKDEKTLQKKEPSKSSIKKKMTKVAEAKKVMKRNFKVNKKITFTDEGELVQQWPQMQKSAIKDAEEDDDTGGINLHKAKERLQEEDKFDKEEYRKKIKAKHREKRLKEREARREANKRQAKAKDEEEAFLDWSDDDDDDDDGFDPSTLPDPDKYRSSEDSDSEDMENKISDTKKKQGMKKRSNSEVEDVGPTSHNRKKARWDTLEPLDTGLSLAEDEELVLHLLRSQS
What is the function of this protein?
Putative ATP-dependent RNA helicase.
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX10, DEAD box protein 10.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
Protein: CD3G_RAT
Sequence: MEQGKGLAGLFLVISLLQGTMAQQKEEKHLVKVDDSQGDGSVLLTCDFNEKTITWLKDGHRISPPNATKSTWNLGNGAKDPRGMYQCRGAKKKSQLLQVYYRLCENCIELNMGTVSGFIFAEIISIFFLAVGVYFIAGQDGVRQSRASDKQTLLQNEQVYQPLKDREYEQYSRLQGNQVRKK
What is the function of this protein?
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.  When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.  All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.  Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.  In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface.  Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
What are the official names of this protein?
T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: OPPB_HAEIN
Sequence: MLKFIFKRLLEALPTLFILITFSFFLMRLAPGSPFTSERAYPPEVMANIEAKYHLNEPLYKQYFLYLENLSKGDFGPSFKYKDQSVNDLIASAFPVSIKLGMVAFAFAVVLGVTAGTLAALNQNSRWDYILMSFSMLGVIMPSFVFAPVLVLIFAIYLGWLPAGGWNGGTAMYMILPVASLTIAYVAGIARIMRGSMIEVLHSNFIRTAKAKGLSMSRIILKHALRPALLPVITYLGPAFVGIITGSMVIESVFGLPGMGLLFVNGALNRDYSLVLSLTILVGTLTILFNAIVDILYAIIDPKIRY
What is the function of this protein?
Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Oligopeptide transport system permease protein OppB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1009_THEP3
Sequence: MSGHSKWANIKHKKEKMDAKKGRIFTKLTKDIIKAAKEGGGDPNTNSKLRDAIEKAKANNLPNENIQRAIKKGTGELGGANLEEVIYEGYGPSGTAIIVEALTDNKNRTAGEIRHIFDRHGGSLGAAGSVTWMFDKVGIIIVEKDNSIDEDELAMVAIDAGAQDFSAEDEEFEIITEPSNFQEVKEAIEKAGYKISEAEVTMLPKNTIQLSPEDYEKFEKLIDKLEENDDVQNVYHNVEIEDENDE
What are the official names of this protein?
Probable transcriptional regulatory protein Teth39_1009.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_ORSVC
Sequence: MSYTITDPSKLAYLSSAWADPNSLINLCTNSLGNQFQTQQARTTVQQQFADVWQPVPTLTSRFPAGAGHFRVYRYEPILEPLITFLMGTFDTRNRIIEVRNPQNPTTTETLDATRRVDDATVAIRSAINNLLNELVRGNGMYNQVSFETMSGLTWTSS
What is the function of this protein?
Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.
What are the official names of this protein?
Capsid protein, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: RR3_CYACA
Sequence: MGQKINPLSFRLGINKLHHSSWFARPQSYTAILQEDKKIRDYIFTNLLRASISRIQINRQFNQVELQLHTSRPGVIIGRSGTGIDSLKRNVKNLLSKQSQLKINIIDVTNPDIDAVLLACFISQQLESRTTFKRAVRQAIQRAQKSDIPGIKIQVSGRLNGAEIARTEWIREGRVPLQTLKADLDYATSSAYTSFGVVGVKVWIFKG
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ASB10_HUMAN
Sequence: MLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
What is the function of this protein?
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
Ankyrin repeat and SOCS box protein 10, ASB-10.
What is the protein family that this protein belongs to?
Belongs to the ankyrin SOCS box (ASB) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells.
Protein: MAP2_METJA
Sequence: MEIEGYEKIIEAGKIASKVREEAVKLIXPGVKLLEVAEFVENRIRELGGEPAFPCNISINEIAAHYTPKLNDNLEFKDDDVVKLDLGAHVDGYIADTAITVDLSNSYKDLVKASEDALYTVIKEINPPMNIGEMGKIIQEVIESYGYKPISNLSGHVMHRYELHTGISIPNVYERTNQYIDVGDLVAIEPFATDGFGMVKDGNLGNIYKFLAKRPIRLPQARKLLDVISKNYPYLPFAERWVLKNESERLALNSLIRASCIYGYPILKERENGIVGQAEHTILITENGVEITTK
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
Protein: NU4M_AGKPI
Sequence: PIAGSMVLAAILLKLGGYGIIRMMQILPTTKTDMFLPFIVLALWGAILANLTCLQQTDLKSLIAYSSISHMGLVVAAIIIQTPWGLSGAMALMIAHGFTSSALFCLANTTYERTHTRILILTRGLHNILPMATTWWLLTNLMNIAIPPTMNFTGELLIMSALFNWCPTTIIMLGLSMLITASYSLHMFLSTQMGPTPLNNQTEPTHSREHLLMILHLIPLMMISMKPELII
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: SEP11_BOVIN
Sequence: MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVNNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKN
What is the function of this protein?
Filament-forming cytoskeletal GTPase (By similarity).  May play a role in cytokinesis (Potential).  May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).
What are the official names of this protein?
Septin-11.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Synapse. Cell projection, dendritic spine. Cell projection, axon.
Protein: TRPB_HAEIE
Sequence: MSDTLLNPYFGEFGGMYVPEILVPVLKQLEQAFVEAQNDPTFQAEFADLLKNYAGRPTALTLCRNLTKGTKTKLYLKREDLLHGGAHKTNQVLGQILLAKRMGKTRIIAETGAGQHGVATALACAMLDMPCRVYMGAKDVERQSPNVFRMRLMGAEVIPVQKGSCSLKDACCEAMRDWSANYETTHYLLGTAAGPHPFPTIVKEFQKMIGEETKRQILEREGRLPDAVIAAVGGGSNAIGMFADFIDESNVRLIGVEPAGKGIETGEHGAPLKHGTTGIYFGMKSPIMQDKDGQIEESYSISAGLDFPSVGPQHAYLNEIGRADYVSITDEEALNAFQELAKHEGIIPALESSHALAYALKLIKQNPEKEQLLVVNLSGRGDKDIFTVDKILNGGTN
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: ISPD_LACE2
Sequence: MNTAIVLAGGSGKRMHSEIPKQYMQLNGKPVIYYSLKAFEESEHVDEIILVTAKEYIEYVRNEIAGSQFAKLTKIIEGGKERFDSVWAGLQQISEKGYVYIHDGARPCINQNIINACWETVVQTDACVAAAPVKDTIKVADADEYAINTPDRKTLWQIQTPQVFSADVIKEAYSRLYEQNCFDGVTDDAMVVERYGNSKIKLVNCGYCNIKITTPEDMEIAGIFLKG
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: SCD1_SCHPO
Sequence: MAYFQDRKTSSRSLPSYINHSTQNLVGPRKDETNLSEYMKLRLLQSPSQVIYNLENTVSLYRRCLNLRKRLMDISELAAFFDSIHREALNSSFKILEFKDIEFDDPVTEIWLFCRLGYPLCALFNCLPVKQKLEVNSSVSLENTNVCKASLYRFMLMCKNELGLTDAALFSISEIYKPSTAPLVRALQTIELLLKKYEVSNTTKSSSTPSPSTDDNVPTGTLNSLIASGRRVTAELYETELKYIQDLEYLSNYMVILQQKQILSQDTILSIFTNLNEILDFQRRFLVGLEMNLSLPVEEQRLGALFIALEEGFSVYQVFCTNFPNAQQLIIDNQNQLLKVANLLEPSYELPALLIKPIQRICKYPLLLNQLLKGTPSGYQYEEELKQGMACVVRVANQVNETRRIHENRNAIIELEQRVIDWKGYSLQYFGQLLVWDVVNVCKADIEREYHVYLFEKILLCCKEMSTLKRQARSISMNKKTKRLDSLQLKGRILTSNITTVVPNHHMGSYAIQIFWRGDPQHESFILKLRNEESHKLWMSVLNRLLWKNEHGSPKDIRSAASTPANPVYNRSSSQTSKGYNSSDYDLLRTHSLDENVNSPTSISSPSSKSSPFTKTTSKDTKSATTTDERPSDFIRLNSEESVGTSSLRTSQTTSTIVSNDSSSTASIPSQISRISQVNSLLNDYNYNRQSHITRVYSGTDDGSSVSIFEDTSSSTKQKIFDQPTTNDCDVMRPRQYSYSAGMKSDGSLLPSTKHTSLSSSSTSTSLSVRNTTNVKIRLRLHEVSLVLVVAHDITFDELLAKVEHKIKLCGILKQAVPFRVRLKYVDEDGDFITITSDEDVLMAFETCTFELMDPVHNKGMDTVSLHVVVYF
What is the function of this protein?
Required for mating and morphogenesis.  May contain a cryptic binding site for cdc42 that is enhanced by binding Ras.  Interacts directly with scd2.  Promotes the exchange of cdc42-bound GDP by GTP.  Involved in septation and stimulates the elongation of conjugation tubes.
What are the official names of this protein?
Rho guanine nucleotide exchange factor scd1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Located at the growing cell ends and tips of conjugation tubes.
Protein: DENR_MAGO7
Sequence: MADVEQPEAGPSEPQGREVTYCGVCSLPPEYCEYGGTVKKCQDWLQRNNQEMYDRIWSPEALQAATAALSVEAQQRAEKDAKKKAAKAEAAEAKHADKLKKSVVTVKRIERNKRKYVTSVSGLESFGLELKKVAKDFGKKFATGSSVTKVASGGEEIVVQGDVSDEIKEFIVEKYKDVPEDNIELVDDKKNKKKEAATAAG
What are the official names of this protein?
Translation machinery-associated protein 22.
What is the protein family that this protein belongs to?
Belongs to the DENR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_BORPA
Sequence: MYKLVLIRHGESQWNLENRFTGWTDVDLTETGREQARKAGELLKREGYAFDLAYTSVLKRAIRTLWIALDALDAMYTPVGINWRLNERHYGQLQGLNKAETAAKYGDEQVLIWRRAYAIAPEPLDLEDPRHPRFDGRYAKIPADQLPATECLKDTVARVLPFWNESIAPAIRAGRRVLVAAHGNSLRALIKHLDNVSDDDIVGVNIPTGQPLVYELDEDLKPIRHYYLGDAAEIEAAMAAVAAQGKAKKD
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: GPN3_CRYNJ
Sequence: MRYAVLVTGPAGAGKSTFCASLITHAQTIGRSVHLVNLDPAADKFEYEPTIDIRDLINLEDVMEELEFGPNGGLIYCFEYLLNNLDWLEDELGAYEDDYLIIDCPGQIELYTHVPLLPRLATFLSTSLNFRTSAVYLIDSQFMQDKSKFFAGVMSAMSCMLSLGISMLCLMSKMDLVKDKKGRTKREVGRYLDPDPNLLLEDINQGTNSKFNQLNRAVVSLIEDQNIVSFLPLDVTSEDSVNTVLSHIDNMMQYGEDEEPKVPKDMDDGEFVAPPRSYNIKLIVRDR
What is the function of this protein?
Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII).  May act at an RNAP assembly step prior to nuclear import.
What are the official names of this protein?
GPN-loop GTPase 3.
What is the protein family that this protein belongs to?
Belongs to the GPN-loop GTPase family.
Protein: RECR_SALEP
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQDVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLASEKISELILATNPTVEGEATANYIAELCAEAGVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIIF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: SYE_THET8
Sequence: MVVTRIAPSPTGDPHVGTAYIALFNYAWARRNGGRFIVRIEDTDRARYVPGAEERILAALKWLGLSYDEGPDVGGPHGPYRQSERLPLYQKYAEELLKRGWAYRAFETPEELEQIRKEKGGYDGRARNIPPEEAEERARRGEPHVIRLKVPRPGTTEVKDELRGVVVYDNQEIPDVVLLKSDGYPTYHLANVVDDHLMGVTDVIRAEEWLVSTPIHVLLYRAFGWEAPRFYHMPLLRNPDKTKISKRKSHTSLDWYKAEGFLPEALRNYLCLMGFSMPDGREIFTLEEFIQAFTWERVSLGGPVFDLEKLRWMNGKYIREVLSLEEVAERVKPFLREAGLSWESEAYLRRAVELMRPRFDTLKEFPEKARYLFTEDYPVSEKAQRKLEEGLPLLKELYPRLRAQEEWTEAALEALLRGFAAEKGVKLGQVAQPLRAALTGSLETPGLFEILALLGKERALRRLERALA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPO12_SCHPO
Sequence: MSETQADSIAKSSVETTIQPLHQESATLRQQVLQKHELPKHALNVASPTDSLMSPCTAKLQAHKKKYYMKRKPPVMSLQNTLQSVQTEKE
What is the function of this protein?
Has a role in controlling mitotic cell cycle progression at the G2/M transition phase.
What are the official names of this protein?
Mitosis-specific protein spo12.
What is the protein family that this protein belongs to?
To yeast SPO12.
Protein: SIR2_KLULA
Sequence: MTEYYGTLQKRPLEQESVAEGNGGLESGKKARGDSDVFAARSPENEDVDVDADADVDADADADADAEEDAQKDILEETKADELDEVVDEYEEKEVSSNFNGTASDHVGITSSNTGSTALAASSADTNSGSGNGTGTMATNGTLSDRQYAPQKPEHPIKLERRSVSRKYVFPVISKEDSLNARSYLKQFGSARFLDDYLPEDLNSLYVYHMIKLLGFQIKDKELMLAIQEVVHNADNDDSLPQKNSSETKNVSDTYTATYPSPSFEDPLEKKHAVRLIKDLQKAMNKVLSTRIRLTNFHTIDDFVAKLKTAKKIIVLTGAGISTSLGIPDFRSSEGFYSKLGDLGLNDPQDVFSLEVFTEDPSVFYNIAHMVLPPENMYSPLHSFIKMIQDKDKLLRNYTQNIDNLESYAGVEPEKMVQCHGSFATASCVTCHWKIQGERIFPNIRNLQLPICPYCYSKRLEFFKTKTDEELADGEDDDMDDHHGRSVPKSFGVLKPDITFFGEALPSKFHRLIREDVLQCDLLICIGTSLKVAPVSEIVNMIPAHVPQVLINKDPVKHAEFDLSLLGLCDDVAALVAQKCGWDIPHDNWNKLKNKVFDSEEVERGVYKVHPLNESPAELEAEEEKHLPLQQSTAALTPPVSLSADSPGRSSSSSPQPPTQTDIANNQTST
What is the function of this protein?
NAD-dependent deacetylase, which asts as a key regulator of gene expression believed to help form modified chromatin structures on the genes it regulates.  It is involved in telomeric silencing and in hm mating type loci silencing (By similarity).
What are the official names of this protein?
NAD-dependent histone deacetylase SIR2, Regulatory protein SIR2, Silent information regulator 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DHDDS_MOUSE
Sequence: MSWIKEGELSLWERFCANIIKAGPVPKHIAFIMDGNRRYAKKCQVERQEGHTQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLLDLARQKFSCLMEEQEKLQKHGVCIRVLGDLHLLPLDLQEKIAHAIQATKNYNKCFLNVCFAYTSRHEIANAVREMAWGVEQGLLEPSDVSESLLDKCLYSNHSPHPDILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWNLCEAILQFQRNHGALQKARDMYAEERKRRQLERDQAAVTEQLLREGLQASGDAQLRRTRLHKLSTKREERVQGFLKALELKRANWLALWGTASA
What is the function of this protein?
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery.  Both subunits contribute to enzymatic activity, i. e.  condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).  Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length.  Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.
What are the official names of this protein?
Dehydrodolichyl diphosphate synthase complex subunit Dhdds, Cis-isoprenyltransferase, CIT, Cis-IPTase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Note=colocalizes with calnexin.
Protein: Y1375_PARPJ
Sequence: MIIVLSPAKSLDYETPPHVRKHTIPDFVDDAAELIGGLRRLSPQQIASLMDISDQLAHLNFQRYAEWSPKFGTHNAKQAVLAFNGDVYEGFNAKTLSSADLDYAQNHVRVLSGLYGLLRPLDLLQPYRLEMGTRFANPRGKDLYAFWGERITQALNAQLKKNAVASRVLVNCASGEYFKSVKPKLLEAPIITPVFEDWKGGRYKIISFHAKRARGLMARYAVENRIDRPEQLKDFDADGYAFDAEASNDSTYVFRRRVVE
What are the official names of this protein?
UPF0246 protein Bphyt_1375.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: MSHR_PONPY
Sequence: MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGAWCLEVSIPDGLFLSLGLVSLVENVLVVATIAKNRNLHSPMYCFICCLALSDLLVSGGNVLETAVILLLEAGALAARAAVVQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAIAAIWVASVLFSTLFIAYYDHAAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPQHPTCSCIFKNFNLFLALIICNAIIDPLIYAFRSQELRRTLKEVLTCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CH10_SHEPC
Sequence: MNIRPLHDRVIVKRLEVESTSAGGIVLTGSAAEKSTRGEILAVGNGRILENGTVKPLDVKVGDVVIFNEGYGVKKEKIDGQEVLILSEADLMAVVG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_KLEP3
Sequence: MATGKIVQVIGAVVDVEFPQDAVPRVYEALEVQNGKEVLVLEVQQQLGGGIVRTIAMGSSDGLRRGLEVKDLEHPIEVPVGKATLGRIMNVLGQPVDMKGDIGEEERWAIHRAAPSYEELSSSQELLETGIKVIDLMCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMTDSNVIDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIASLGIYPAVDPLDSTSRQLDPLVVGQEHYDTARGVQSILQRYQELKDIIAILGMDELSEEDKLVVARARKIQRFLSQPFFVAEVFTGSPGKYVALKDTIRGFKGIMEGEYDHLPEQAFYMVGSIDEAVEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: OGG1_THESQ
Sequence: MEELLKELERIREEAKPLVEQRFEEFKRLGEEGTEEDLFCELSFCVLTANWSAEGGIRAQKEIGKGFVHLPLEELAEKLREVGHRYPQKRAEFIVENRKLLGKLKNLVKGDPFQSREFLVRNAKGIGWKEASHFLRNTGVEDLAILDKHVLKLMKRHGLIQEIPKGWSKKRYLYVEEILRKVAEAFGESPGKFDLYLWYLVKGKVDK
What is the function of this protein?
Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA.  Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).
What are the official names of this protein?
8-oxoguanine DNA glycosylase/AP lyase.
What is the protein family that this protein belongs to?
Belongs to the type-2 OGG1 family.
Protein: MNMG_ORITB
Sequence: MNKFDVVVVGGGHAGCEAAAAAARIGVKVALITLKPENLGEMPCNPAIGGRGKGHIVKEVDALDGLIGYIADQAGIHYKMLNHTKGPAVWGPRAQIDRALYKSAMYSTIMNYPNLTTIFASVEDIKVIANKVTAVIVNGKEIYCQKVILTTGTFLSGVIHRGKEQIKAGRLGENASYGLSNTLSELGLRLGRLKTGTPPRIDSRTIDYSKLEEQPGDLIPTPFSEITKKVLVPQIKCYITRTNEITHKIIKENLHLSAMYSGQIQGTGPRYCPSIEDKIIRFSHNASHQIFLEPEGLNSNTIYPNGISTSLPSDVQENMIRTIEGLENCKIIAYGYAIEYDYVDPRQLKHSLEVKSVGGLYLAGQINGTTGYEEAAGQGIMAGINAALAVKKQDPFILDRTDAYIGVMIDDLTNGIDEPYRMFTSRSEYRLSIRADNADQRLTPKAIDLGCVSQLRQEVFQKKLSKLNTLRDYVQSLTITPKQLQNCGYQISQNGIARTAFSLLGLPNFGINIVKDIYPELNRYDNNLLLLLTYESKYHVYLERQKEDIELFKQEETYQIPQDLNYDQIPSLSIEVREKLKQYQPETIRAAKHINGVTPSAIMAIIIFLKTKYLNSSITDKK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.