PharMolix/UniProtQA huggingface dataset:
Protein: TFDB_CUPPJ
Sequence: MALTIETDVLVVGTGPAGASAGALLARYGVRTMLINKYNWTAPTPRAHITNQRTMEILRDLGLEAEARLYAAPNDLMGENTICASLAGEEFGRIRTWGTDVRRRADYDECSPTSMCDLPQNYLEPILVKSAALDGCKVRFDTEYLGHEQDADGVSSRLRDRLNGEEFTVRSKYLIGADGANSRVVSDLDLPLEGTMGKSGSINLLFEADLDRYVAHRPSVLYWVIQPGSDIGGLGIGVVRMVRPWNKWLAIWGYDVEQGPPEISESFARRIVHNLIGDDSVPLKIEGISTWTVNDMYATRLQQGRVFCAGDAVHRHPPTNGLGSNTSIQDSFNLAWKIAMVLNGTADESLLDTYTIERAPIAKQVVCRANKSLEDFPPIAMALGLPQAKSADEMKSNMARRKEPGPEAQAQRTRLREAIAGTNYVYNAHGVEMNQRYDSPAIVADNSPDEVFRDVELYHQASTRPGAPMPHVWVYASGDGHRISTKDLCGKGNFTLFTGIGGAAWQDAAAAVSRQLGVAVTVRIIGPGQAYEDHYGDFARISEIIDTGAILVRPDFHVAYRATSLPADAAGDLVSAMRRILGRQSERSSALRVTSRAI
What is the function of this protein?
Transforms 2,4-dichlorophenol (2,4-DCP) into 3,5-dichlorocatechol.
What are the official names of this protein?
2,4-dichlorophenol 6-monooxygenase, 2,4-dichlorophenol hydroxylase, 2,4-DCP hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: HTAI2_PANPA
Sequence: MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFARVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVXLCDRQESRPGEWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSLKP
What is the function of this protein?
Oxidoreductase required for tumor suppression.  NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors.  May act as a redox sensor linked to transcription through regulation of nuclear import (By similarity).
What are the official names of this protein?
Oxidoreductase HTATIP2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope.
Protein: TLP_SENDI
Sequence: ATITFTNKCTRTVWPGTLTGDQKPQLSKTGFELASGVSTRGAAPPATLIELTVAS
What is the function of this protein?
Has antifungal activity against C. albicans 586 (EC(50)=6. 2 uM), C. parapsilosis ATCC 22019 (EC(50)=2. 2 uM), C. krusei ATCC 14243 (EC(50)=2. 5 uM) and C. krusei 80 (EC(50)=5. 4 uM).  Has no activity against C. neoformans, C. tropicalis or T. glabrata.
What are the official names of this protein?
Thaumatin-like protein, CdTLP.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: USPB_ECOLC
Sequence: MISTVALFWALCVVCIVNMARYFSSLRALLVVLRNCDPLLYQYVDGGGFFTSHGQPNKQVRLVWYIYAQRYRDHHDDEFIRRCERVRRQFILTSALCGLVVVSLIALMIWH
What are the official names of this protein?
Universal stress protein B.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYA_LACP3
Sequence: MKKMSSGEIRQMFLDFFKSKGHAVEPSASLIPVDDPTLLWINSGVATLKKYFDGSVVPDNPRITNAQKSIRTNDIENVGKTARHLTFFEMLGNFSVGDYFKKEVIPWAWELLTSPKWFGFDPKRLYVTVYPKDKVTKELWQKTGVPDDHIVEAEDNFWDIGEGPSGPDSEIFYDRGQQFNNVAEDDPENYPGGENSRYVEIWNIVFSELNHLPDGRFVEQPHKNIDTGMGLERLVAVIQGTPTIFETDLFMPIIKATEKMSAGKRYGVSAQDDVSFKIIADHARTVTFAIGDGALPSNEGRGYVLRRLIRRAVLNGKKLGIDHDFLYQLVPVVGEIMKSYYPQILANQQFIQKVIESEEARFRQTLDAGVTLLNQIIADLKQDGKKEIPGADAFKLFDTYGFPVEMTNEYAQDEGLQVDMAGFKKNMAAQRDRARKARGDRQSMGSQDKVLMSITTPSKFTGWTELDHKHASLQTIVVNDQLQDSVSEGTAQLIFDETPFYAEMGGQVADHGEIKAQDGTVLADVSDVQHAPNGQNLHTVTVKGKLETGQQYWLSVDPLRRKKVSLNHTATHLLDQALRDVLGEHTHQAGSLVEPDYLRFDFTNFGQVTPKQLRQVETIVNQKIWDALPITWKEMPIEEAKKLGAIAMFGDKYGSVVRIVKIGDYNTEFDGGTHPTNSNALGLFKITSESGIGAGIRRVEAVTSKEAYEYLTQQQDWLSETAENLKIDQVKNVPSKVTQLQADLKAEQKTVAGLQAKLAAQAAAGIFDHPEEVGGLKLIAKQVQVAGMNELRQLADKWKAKQASDILVLGTEVSGKANLLVAVNDTANQAGFKAGDLIKAIAPKVGGGGGGRPDMAQAGGKNPAGIPAALSEAKTVISQKA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSD_PSEPW
Sequence: MKKTALLNIALSRTIAGLGHGDILVIGDAGLPVPPGVELIDLALTPGIPDFASVLRAVLSEMQVERHVLAEEMQKVVPPGLVEIERLRGKLGKREWLSHEQFKVLSRSARAVVRTGECQPYSNIALIAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_STRSY
Sequence: MHQFTTWTGTTVPLMNDNIDTDQLLPKQFLKLIDKKGFGKYLLYAWRYLDDNYTDNPDFILNQPEYQGASILISGDNFGAGSSREHAAWALADYGFKVIIAGSFGDIHYNNDLNNGILPIIQPKEVRDQLAQLGPDQEITVDLADQLIRTPFGECPFDIEQDWKHKLLNGLDDIGITLQYQDLIAEYEDNRPSYWQN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: TRYM_CANLF
Sequence: MLWLLVLTAPWLGGSVPISPDPGLRHEQVGIVGGCKVPARRYPWQVSLRFHGMGSGQWQHICGGSLIHPQWVLTAAHCVELEGLEAATLRVQVGQLRLYDHDQLCNVTEIIRHPNFNMSWYGWDSADIALLKLEAPLTLSEDVNLVSLPSPSLIVPPGMLCWVTGWGDIADHTPLPPPYHLQEVEVPIVGNRECNCHYQTILEQDDEVIKQDMLCAGSEGHDSCQMDSGGPLVCRWKCTWIQVGVVSWGYGCGYNLPGVYARVTSYVSWIHQHIPLSPGP
What is the function of this protein?
Trypsin-like serine protease.  Has a preference for extended substrates with basic residues at the P1 position; Arg is preferred over Lys.  Active towards calcitonin gene-related peptide and gelatin.  Not active towards substance P, vasoactive intestinal peptide, type I collagen or azocasein.
What are the official names of this protein?
Mastin, Mast cell protease 3, DMP, MCP-3, dMCP-3, Mastocytoma protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: LEUD_SHEHH
Sequence: MQPFISHTGLAVILDSANVDTDQIIPKQFLSKVTRDGFGVHLFHDWRYLDEAGDKPNPDFNLNQPRYKGASILVSQENFGCGSSREHAPWALADFGFKVIIAPSFADIFYGNSINNGLLPVRLTDAEVKQLMAEVEAKEGAEIDVDLQALTVTSPSGALFHFEIAQSARHNLLNGLDAIGLTLSHVDTIANYEANIPSWRG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: ASIP_HORSE
Sequence: MDVIHLFLATLLVSLCFLTAYSHLSPEEKPKDDRSLRNNSSMNLLDSPSVSIMALNKKSKKISRKEAEKKKRSSKKKASMTKVARPRLLQPAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLTRTC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: ADD37_YEAST
Sequence: MAIKPTKSFQNCLEAEVPGYNDCPTVLFSIDPNSGPRSKSKQRTKSKRCVSGRLATEVLDLYGNTKTATTPPPVLRRPSVTAAQQESACEGVLVKDQGDRQLQPILCSKEELVAKINDLCVCGSKLSSKELEFYKKKLDSNITKILQNEHTKTVLSQIFNEKDKNMAVKTIKHWMVTDTTISNWCPAFLKIFENAMPN
What is the function of this protein?
Involved in ER-associated protein degradation (ERAD).
What are the official names of this protein?
Alpha1-proteinase inhibitor-degradation deficient protein 37.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRB_LISW6
Sequence: MDESKKNERLKQLTDIQYNVTQKAGTERPFQNEFYDNAAKGIYVDIVSGKPLFSSTDQYDAGCGWPSFTKPIDEAEVKEHKDRTHGMIRTEVKSVDADSHLGHVFPDGPQDKGGLRYCINSAALRFIPVDKLDDEGYQAYKKIFE
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: VG65_BPML5
Sequence: MYTPRQSLYIRGSAGDPLPPVWAALDQKGTHLRRGQLVLVCAGPGTGKSAFVLAYALKSKVPTLYFSADSDAFTQLSRSVSILSGWSLERATRAVREQNIEDAVADSLDEIPIRFNYKASPSLDEIENALAAYDALYEDFPALIVVDNITNVRTDSSEGDDPFSGLESLMDYLHEMGRETGSCVVGLHHVTGPHNDGDKPIPLSGIKGQIGRVPEMILTLHRVSDGFGPDMLNVSTVKNRGGKSDPSGQDFASLEFVGDTMQINDFGH
What are the official names of this protein?
Gene 65 protein, Gp65.
Protein: DPO4_STAA1
Sequence: MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGLTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COE4_MOUSE
Sequence: MFPAQDALPRGGLHLKEEPLLPSSLGSVRSWMQSAGILDSNTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGTEKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIIIGDNFFDGLQVVFGNVLLWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPSSNQELLLKRAADVAEALYSAPRAPAPLGPLAPSHPHPAVVGINAFSSPLAIAVGDTTPEPGYARSCGSASPRFAPSPGSQQSSYGSGLGAGLGSYGAPGVTGLGVPGSPSFLNGSTATSPFAIMPSSPPLAAASSMSLPAAAPTTSVFSFSPVNMICAVKQRSAFAPVLRPPSSPSQACPRAHREGLPDQPFEDTDKFHSAARGLQGLAYS
What is the function of this protein?
Transcription factor (PubMed:12139918).  Positively modulates transcription, perhaps less strongly than other early B cell factor/EBF family proteins (PubMed:12139918).  Binds an EBF1/Olf-1 consensus site in vitro (PubMed:12139918).
What are the official names of this protein?
Transcription factor COE4, Early B-cell factor 4, EBF-4, Olf-1/EBF-like 4, O/E-4, OE-4.
What is the protein family that this protein belongs to?
Belongs to the COE family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ELK4_MOUSE
Sequence: MDSAITLWQFLLQLLQEPQNEHMICWTSNNGEFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILKMDPLTVGRIEGDCEALNSIETSSSKDVEYGGKERPPQPGAKTSSRNDYIHSGLYSSFTLNSLNTSNKKLFKSIKIENPAEKLAEKKAQEPTPSVIKFVTTPAKKPPIEPVAAAFATSPSLSPSSEETIQALETLVSPTLPSLETPASISILATTFNPTPPVPSTPLPLKEPPRTPSPPLSSNPDIDTDIESVASQPMELPENLSLEPKNEDSALPEKDKTNNSSRSKKPKGLELTPALVVTGSDPSPLGILSPSLPTASLTPALFSQTPILLTPSPLLSSIHFWSTLSPFAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT
What is the function of this protein?
Involved in both transcriptional activation and repression.  Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression.  Forms a ternary complex with the serum response factor (SRF).  Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity).
What are the official names of this protein?
ETS domain-containing protein Elk-4, Serum response factor accessory protein 1, SAP-1, SRF accessory protein 1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GRPE_SHIBS
Sequence: MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEFB5_ORNAN
Sequence: MRGLLPFLFLLSFFLSPIQAQPEGREEELEETWSEDRDQAPPRVVEESEVVGAENEAGLAAGRSYPWIILKKCRERGGQCHSGVCSWNEKFIGFCSFARPCCRKRRAVP
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Defensin-B5, DefB5, OaDefB5.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISCA2_MOUSE
Sequence: MAASRALSLTAEAVRAVIPRRSGRLLAVFPRLLTRWETTSSIPEAGEGQIRLTDSCVQRLLEITEGSEFLRLQVEGGGCSGFQYKFSLDTVINPDDRVFEQGGARVVVDSDSLAFVKGAQVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSVKV
What is the function of this protein?
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway.  May be involved in the binding of an intermediate of Fe/S cluster assembly.
What are the official names of this protein?
Iron-sulfur cluster assembly 2 homolog, mitochondrial, HESB-like domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: QUEF_AGRFC
Sequence: MSVTDVSGLSQLGTKVDTPESPEKAVLEKVPNGNAGTDYVVRFTAPEFTSLCPMTGQPDFAHIVIDYIPGDFLVESKSLKLFLQSFRNHGAFHEDCSVYIAKRLVELLQPKWLRIGAYWYPRGGIPIDVFWQTGAAPEGVWLPDQGVAPYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_SALCH
Sequence: MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFDGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLEIKDWRQVELNPFFCPDADKLDALDELMRALKKEGDSIGAKVTVMASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGEGFNVVALRGSQNRDEITAQGFQSNHAGGILGGISSGQHIVAHMALKPTSSITVPGRTINRAGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRHRAQNADVKTEIPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RFRNP_METM7
Sequence: MQKQRFCLDTTAITDSDVRRSLGVSNISESAEKIMDIIAQARVQLDISCHIPYNTVYKELVGFLIREECAPETLIKVDTWLVKKTPNRYEIKIPAEIFYEYIKDLRERINKGMRISENAMYETALEAYILSKPDEKDREDVLNEVLSKTVNSFRDKYRNTLRGGTLDSAPDLDVLLLAKELDAAVVANDEGIEKWAQRLGLRFVNARDFPFILQEYLDLWDKK
What is the function of this protein?
RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.
What are the official names of this protein?
RNA-free ribonuclease P, RNA-free RNase P, Protein-only RNase P.
What is the protein family that this protein belongs to?
Belongs to the HARP family.
Protein: RL10_PARMW
Sequence: MGRTLESKQQIVGELKELLAESELALVLDYKGLSIKEMSDLRDRLRAGNAVCKVTKNTLMRRAIDGDSAWSNLDSLLTGTNAFVLIKGDVGAGVKAVQAFQKETKKSETKGGLFEGKLLSQDEIKAIADLPSKEQLMAQIAGAINAVATKVAVGINEVPSGLARALKQHAEGGDS
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: DXO_MOUSE
Sequence: MEPRGTKRKAEKTEVEKPLNKLPRAVPSLRTQPSLYSGPFPFYRRPSELGCFSLDAQRQYHGDARALRYYSPPPINGPGPDFDLRDGYPDRYQPRDEEVQERLDHLLRWVLEHRNQLEGGPGWLAGATVTWRGHLTKLLTTPYERQEGWQLAASRFQGTLYLSEVETPAARAQRLARPPLLRELMYMGYKFEQYMCADKPGGSPDPSGEVNTNVAYCSVLRSRLGNHPLLFSGEVDCLNPQAPCTQPPSCYVELKTSKEMHSPGQWRSFYRHKLLKWWAQSFLPGVPHVVAGFRNPEGFVCSLKTFPTMEMFENVRNDREGWNPSVCMNFCAAFLSFAQSTVVQDDPRLVHLFSWEPGGPVTVSVHRDAPYAFLPSWYVETMTQDLPPLSKTPSPKD
What is the function of this protein?
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (PubMed:28283058, PubMed:32374864).  The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (PubMed:28283058).  In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:28283058).  Preferentially acts on NAD-capped transcripts in response to environmental stress (By similarity).  Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (PubMed:23523372, PubMed:28283058).  Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control (PubMed:23523372).  Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:23523372).  In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA (PubMed:23523372).  Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs (PubMed:23523372, PubMed:30180947).  Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (PubMed:23523372).  Exhibits decapping activity towards FAD-capped RNAs (PubMed:32432673, PubMed:32374864).  Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673, PubMed:32374864).
What are the official names of this protein?
Decapping and exoribonuclease protein, DXO, 5'-3' exoribonuclease DXO, Dom-3 homolog Z, NAD-capped RNA hydrolase DXO, DeNADding enzyme DXO.
What is the protein family that this protein belongs to?
Belongs to the DXO/Dom3Z family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FIBB_ELEMA
Sequence: ATDYEDEEFPGAVPPSVGAR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: AROE_PELPB
Sequence: MTKSTKILGLIGRAVDYSYSPLIHNTACRLLGLSYHYTVFNIADPSMIPDALRGAKALGIAGFNVTIPYKKSVVPFLDALSAEAASIQAVNTIVNEGGKLTGHNTDIAGFAAPLLPYRESIRGKTLSIFGAGGAALAAIEAFIRFFSPKEILLFVRNPEKASLLLEESGHDKSAPVRILCSDNPEIIRECRVIVNATPIGTRGNNDSPLPLDRELLHPGQIVYDMVYNPLDTPLLLAAQKAGAATISGIEMLIGQAEHSFTLWTGMQMPVKAVKESLLQEIQQ
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: S39A1_MOUSE
Sequence: MGPWGEPELLVWRPEAVASEPSVPVGLEVKLGALVLLLLLTLICSLVPVCVLRRSGANHEASASGQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALEALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQTSPPHPEETRALLGTVNGGPQHWHDGPGIPQAGGTPAAPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRVQVVAGCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFVQI
What is the function of this protein?
Transporter for the divalent cation Zn(2+).  Mediates the influx of Zn(2+) into cells from extracellular space.
What are the official names of this protein?
Zinc transporter ZIP1, Solute carrier family 39 member 1, Zinc-iron-regulated transporter-like, Zrt- and Irt-like protein 1, ZIP-1, mZIP1.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NADM_METLZ
Sequence: MRRGLYVGRFQPFHNGHKAVIDGLAEEVDELIIGIGSADISHDIRHPFTAGERVLMITRALNGLKIPFYVIPLEDVKRNALWVAHVKSMVPPFDTVYTSNPLVIQLFKEAGIPVLSPPMYLRESLSGTAVRKKMYHGEAWEEYVPKEVVSVVGEIHGIERMQQISKSD
What are the official names of this protein?
Nicotinamide-nucleotide adenylyltransferase, NAD(+) diphosphorylase, NAD(+) pyrophosphorylase, NMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the archaeal NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.