PharMolix/UniProtQA huggingface dataset:
Protein: SSRP_SERP5
Sequence: MTKKKAHKPGSATIAQNKRARFEYAIEEEFEAGLSLQGWEVKSLRAGKANISDSYVTFRDGEAYLFGATVSPLNVASSHVVCDPTRTRKLLLKKRELDSLLGRVNRDGYTVVALSMYWKNAWAKIKIGVAKGKKEHDKRDDIKDREWQTAKSRIMKHANR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: COBS_STUS1
Sequence: MLPLLIALQFLTSLPIRLPAMPTPRQQGRSLLHYPAVGLFLGALLWLAALLLEGASPLLQAALLLALWVALTGALHLDGLADSADAWLGGFGDPARTLEIMKDPRSGPVAVVVLVIMLLLKFSALLVVLQAQQPAALVLAPLLGRAALLALFLCTPYVRPNGLGQALAANLPRSRALMVLALVVIGCLLLGATGLLALTLAGVTFLLARRAMLRRLGGTTGDTAGALLELVECAVLVGLALQVGR
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
Protein: NU5C_SYNY3
Sequence: MELLYQLAWLIPVLPLFGATVVGIGLISFNQATNKLRQINAVFIISCLGAALVMSGALLWDQIQGHASYAQMIEWASAGSFHLEMGYVIDHLSALMLVIVTSVALLVMIYTDGYMAHDPGYVRFYAYLSLFASSMLGLVISPNLVQVYIFWELVGMCSYLLIGFWYDRKAAADACQKAFVTNRVGDFGLLLGILGLYWATGSFDFGTIGERLEGLVSSGVLSGAIAAILAILVFLGPVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGVFLVARMYPVFEPIPVVMNTIAFTGCFTAFLGATIALTQNDIKKGLAYSTISQLGYMVMAMGIGAYSAGLFHLMTHAYFKAMLFLCSGSVIHGMEGVVGHDPILAQDMRIMGGLRKYMPITATCFLIGTLAICGIPPFAGFWSKDEILGLAFQANPLLWFVGWATAGMTAFYMFRMYFMTFEGGFRGNDQEAKDGVLQFYGLLPNFGPGAMNVKELDHEAGHDDHGHSSEPHESPLTMTFPLMALAVPSVLIGLLGRPWANQFEAFIHAPGEVVEHAAEFEWGEFYVMAGNSIGIALIGITVASLMYWQHKFDPKVLAEKFPSLYQLSLNKWYFDDLYDKLFVQGSRRVARQIMEVDYKVIDGAVNLTGLVTLVSGEGLKYLENGRAQFYALIVFGAVLGFVIVFSLT
What is the function of this protein?
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 5, NAD(P)H dehydrogenase I, chain 5, NDH-1, chain 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LGT_CLOB6
Sequence: MNPIAFHVGNLAIRWYGVIISIGAALGLLLAMYNCKIREASYDEFINMFLIAFPSAIIGARLYYVIFEFEDYRDNLINIFNTRQGGLAIHGGIIFGVLAVYIYLKYRKESFFEYVDVAAPSIILGQAIGRWGNFFNSEAHGGPVTKEFISKFPQFIQKGMFIEGTYYHPTFLYESIWNFIVCIFLVYLLKKTKKKGIVFMAYIGLYSLGRFFIEGLRTDSLYLGSIRVAQLISVLGIILSIFFIYNIIKN
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL31_ACIBC
Sequence: MRADIHPKYEKLVATCSCGNVIETRSALGKETIYLDVCSACHPFYTGKQKNVDTGGRIDKFKQRFAGMSRSIKR
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: PYRH_HELAH
Sequence: MQTKIKNKRVLVKFSGEALAGDNQFGIDIHVLDHIAKEIRSLVENDIEVGIVIGGGNIIRGVSAAQGGIIRRTSGDYMGMLATVINAVAMQEALEHIGLDTRVQSAIEIKEICESYIYRKAIRHLEKGRVVIFGAGTGNPFFTTDTAATLRAIEIGSDLIIKATKVDGIYDKDPNKFKDAKKLDTLSYNDALIGDIEVMDDTAISLAKDNKLPIVVCNMFKKGNLLQVIKHQQGVFSMVK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_STRPI
Sequence: MIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLKGRRQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLSISHTDQFVTASVILEENHES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_SACD2
Sequence: MGKIIGIDLGTTNSCVSILEGNKAKVIENSEGDRTTPSIVAFTEDGEILVGQSAKRQAVTNPQNTLFAVKRLIGRKFTDDVVQKDISMVPYKIIAADNGDAWVEVKGDKKAPPQISAEVLKKMKKTAEDYLGETVTEAVITVPAYFNDSQRQATKDAGKIAGLDVKRIINEPTAAALAYGMDKSKGDSTIAVYDLGGGTFDISIIEIADVDGEHQFEVLSTNGDTFLGGEDFDLRLIEYLAEEFKKTNGIDLHNDPLALQRLKEAAEKAKIELSSSQQTEVNLPYITADATGPKHLVVKLSRAKLESLVEELVNRSLEPLKMAIKDAGVSVSDIDDVILVGGQTRMPMVQAAVAKFFGKEPRKDVNPDEAVAMGAAIQGAVLSGDVKDVLLLDVTPLSLGIETMGGVATPLIEKNTTIPTKKSQVFSTADDNQTAVTIHVVQGERKQASQNKSLGRFDLADIPPAPRGMPQIEVTFDIDANGILNVSAKDKATGKEQSIVIKASSGLSDDEIEKMVQDAEANADADRKFEEVVTARNTLEGLIHATKKTLEEAGDKATADEKSAIESAIAEAEEAAKGEDKDAMEAATKKLTEASSSLAQKLYAEQGAAGAGAAGAADAAADQPADDGAVDAEFEEVKEDDGK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: STON2_RAT
Sequence: MTTLDHVIATHQSEWVSFSEEPLFPTPLEGGTEEHFPGLSSSSDRSESSSGENHAVDEGSQDLSHSEQDDSSEKMGLISEAASPPGSPVQPTPDLASAISNWVQFEDDTPWSNTSAPHKETALTLTVPCWTCPSLDSLRRCPLASESSWTTHSEDTSSPSVAPSYTDLQLINAEEQASGRASGTDSTDNSSSLQEDEEVEMETISWWAGSPAMNGHPAVPQVTTARFPSWVTFEDNEVGCPSPTVPSPKKPNAPSAATAGPDVPFNSTGSFKRDRPKSTLMNLSKVQKLDISSLNRPPSVTEAPPWRATNPFLNESLQDIQPSPINPFSAFFEEQERRSQNSSISGTSGKSQRDSLIVIYQDAISFDDSGKSQSHPDAIEKLKQLQIDDPDPVGNAALPDDDPTASVEPDAPSPTSALSQPRDGWPMMLRIPEKKNIMSSRHWGPIYIKLTDSGYLQLYYEQGLEKPFREFKLEICHEVSEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHAAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVQSMDLSTVGLNYLEEEITVDIRDEFSGTVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILIKGNEIVSRQDIMPTTTTKWIKLHECRFHGCVDEDVFNSSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASINGAEVEVQSWLRMSPGFSSNRDPLTQVPCENVMVRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSAGASGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKAAVRSISVEDKPDVRKWVNYSAHYSYKVEIEQKKSLKPDFEGEDLENPKECGVQ
What is the function of this protein?
Adapter protein involved in endocytic machinery.  Involved in the synaptic vesicle recycling.  May facilitate clathrin-coated vesicle uncoating (By similarity).
What are the official names of this protein?
Stonin-2.
What is the protein family that this protein belongs to?
Belongs to the Stoned B family.
What are the subcellular locations of this protein?
Synapse, synaptosome. Cytoplasm. Membrane. Note=Some fraction is membrane-associated.
Protein: DEF_DEIRA
Sequence: MTAPDSSSAPAPLAFGGKPRVYPMRLYGDPILRRKARNLTAADTLHVPGFEPQTVREVADTMLETMFEERGVGLAAPQIGLPVRMFVAVEYADDEEENEGQETPLRSRVLREYVMLNPVVKVINKKKDKSYQEGCLSIPGIYEDGVPRARQVRVDYTDLDGQPRSIEAEDYLARVFQHETDHLDGKLFLDHLPADITEDHRKDLLRIQQASKNFLAQLSEWDKAQRHLKENL
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: NNRD_FUSV7
Sequence: MSTEDLNMSAATKNVLAKVRRIIPPMLESFHKGQLGRVAVIGGSENYTGAPYFSAMASARLGCDMSHVICTPAAATVIKSYSPNLMVHPLMRQSPAPNPNQDPATRDTSKDPDSDPEHISAQIIDLLPRLHVLVVGPGLGRDPLMHATVARVIRAARNRGTPVVLDADALILVQKDPGLVRGYDGAVLTPNVVEFAKLCEALKVDVSEGASETARVEALAKTLEGVTVIQKGAKDYISNGETTLTVDLQGGRKRSGGQGDTLTGSIATFLGWRKAYLDRLWDVGQNALGEHELVGLAAFGGAAITRECSRLAFAKKGRSLQASDLTEEVHVAFLNIFGEEDEETDSSRL
What is the function of this protein?
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP.  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
What are the official names of this protein?
ATP-dependent (S)-NAD(P)H-hydrate dehydratase, ATP-dependent NAD(P)HX dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NnrD/CARKD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_LARHH
Sequence: MAETDKQKALSAALSQIEKQFGKGSIMRMNETQVNDNLQVISTGSLGLDMALGVGGLPRGRVVEIYGPESSGKTTLCLQVVAEAQKLGGTCAYIDAENALDPVYAGKLGVKVDDLLVSQPDTGEQALEICDMLVRSGGVDVIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTGNIKRTNTLVIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAIKKTDEIIGNETRVKVVKNKVSPPFKQAEFDILYGEGISREGEIIEMGVANKFVDKSGAWYAYNGQKIGQGKDNAREWLRENPAIAQEIEKKIRTAAGVGGMNEFVPSSEEQAEASLSEDHDQ
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_ANAMM
Sequence: MLSVILKSSVRGLGKAGEIAKVRPGYARYLLADGKAVRATKDNVALLEQKLALIEEENSKKLAEAEGVAKSLGAERLIIVRQSSDDGKLFGSVTVRDVSKLLCDLGYDIQPRCVSFSEVIKRTGEYEINVELHADLVAALQLHVVRNESEAERVRLGIAKSEDQAAAAAEVEQAEDVAAAEQQDSSPVDDHADDADGATGGEGRDEGAGDASDGEEMPST
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ENO_DINSH
Sequence: MSLIVDVYAREILDSRGNPTVEVDVTLEDGTLGRAAVPSGASTGAYEAVELRDKDTARYFGKGVKTAVAFVNGEIAEALMGIDATDQVGIDSAMIELDGTPNKSRLGANAILGVSLAVAKAAAEATGQPLYRYVGGTSARVLPVPMMNIINGGEHADNPIDIQEFMIMPVSADSIAEAVRMGAEVFHTLKKELSAAGLSTGIGDEGGFAPNLSSTRDALDFVLKAIEKAGYTPGEDIYLALDCAATEYFEDGRYEMKGEGKTLTPEANVDYLEALVNDYPILSIEDGCSEDDWEGWALLTERLGDRVQLVGDDLFVTNPARLAEGIQKGCANSLLVKVNQIGTLTETLSAVDLAHRNRMTCVMSHRSGETEDATIADLAVATNCGQIKTGSLARSDRLAKYNQLIRIEDELGETAIYAGRSILR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL6_META1
Sequence: MSRIGNRILKVPANTEVVIENNHITVKGKLGELHYSFSSLIKVNLENGEITTVRSNEEKTTKQLHGTTNAIIKNMLIGVSEGYKKEIEIKGVGYKATLKGNEIEVIAGYSHPVTLALPSNLKVELPKPTNIIISGIDKQAVGEFAANLRKIRKPSPYSGKGIMYKDEQIRRKEGKTASK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PUR5_NEIMB
Sequence: MSTSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGDLGGFGALVEIGKKYQNPVLVSGTDGVGTKLKLAFDWDKHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATDVIKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEKENVITGRSIGVGDVVLGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFTIKGMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCGIGMVVIVAAEDADAVQGLLGEQGETVYRLGLIRERQGDEHQTQVA
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM61_CRYNB
Sequence: MDIRKPMFHSRVHIEAGDIVILYMARDNMTAITITPGETFHNKYGRYPHDMLIGQKYGSKIHSPPPHPGYVHVLRPTPELWTLSLPHRTQILYLPDISYITMRLGVRVGGKVIEAGTGSGSMTHSLSRSVGPSGQVMSFEYHRQRFETALKEFESHGLTNVRLQHRNVCKEGFGDAQGVEGVFLDLPAPWEAIPHAVKALRRDIITRICCFSPCLEQVLKTVTCLRSEGFSDISTQEVLIRTHELVTPPPNTTYLSSISSVVSYLREHEQRKEERRLLQIKTAKENNRKVKGIEADDAIPVEGETGSKRKLEQPSVTGSDNAAPANSRPKTNLLWTEPPNTLPSTVLTKPSPEMKGHTSYLTFAILYPESVRLSMVAQETSSRVETPTNITKAPETHSQETHYSEGSEIEKIGAMTSKEMDDWMKSGSTSLSI
What is the function of this protein?
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
What are the official names of this protein?
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, tRNA(m1A58)-methyltransferase subunit TRM61, tRNA(m1A58)MTase subunit TRM61.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YCF33_CYAPA
Sequence: MSNFFTNVLRYPLFLISFSLGIFLTFFRWIEPITKKPLNLIVLIISFGTVLMFLNLTFKAMLDLN
What are the official names of this protein?
Uncharacterized protein ycf33.
What is the protein family that this protein belongs to?
Belongs to the ycf33 family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: HCN2_MOUSE
Sequence: MDARGGGGRPGDSPGTTPAPGPPPPPPPPAPPQPQPPPAPPPNPTTPSHPESADEPGPRARLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPSAAEEAGSEEAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWVSINNMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLVGPLALGSPRLVRRAPPGPLPPAASPGPPAASPPAAPSSPRAPRTSPYGVPGSPATRVGPALPARRLSRASRPLSASQPSLPHGVPAPSPAASARPASSSTPRLGPAPTARTAAPSPDRRDSASPGAASGLDPLDSARSRLSSNL
What is the function of this protein?
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions.  Contributes to the native pacemaker currents in heart (If) and in neurons (Ih).  Can also transport ammonium in the distal nephron.  Produces a large instantaneous current.
What are the official names of this protein?
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Brain cyclic nucleotide-gated channel 2, BCNG-2, Hyperpolarization-activated cation channel 1, HAC-1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel HCN family.
Protein: RBL_PIPCE
Sequence: MSPKTETKAYVGFKAGVKDYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTSVWTDGLTSLDRYKGRCYDIEPVAGEENQYICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALFKAQTETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHVHSGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREAAKWSPELAAACEVWKEIKFEFAAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AROB_ACIF5
Sequence: MRSLCVDLGQRSYPIHTGTGILADSALFAPALSKGPVAVVTDSNVAPLYLETLQKTLKALDKPSLSIILPAGEESKSLDNIQEIAGRLLSAGYGRDCTLCALGGGVVGDITGFAAAVYQRGVAYIQVPTTLLAMVDSSVGGKTGVNHPLGKNMIGAFYQPQAVIADTDTLDSLPEREFRSGLAEVIKYGLINDQGFFSWLEDHMDAVLAREPDALTKVIRHSCKDKADIVARDELEGGLRAILNLGHTFGHAIEAATGYGQYLHGEAVAIGMVMAADLSRRLDLIRESEQDRIYALVEATGLPTLAPALPVADYLGFMRVDKKAEGGRVRFILLRGIGSAVITGEVPPAAITQTLQAFMEHGHA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_BURVG
Sequence: MLDPRARTLLKTLIERYIADGQPVGSRTLSRYSGLELSPATIRNVMSDLEELGLVSSPHTSAGRVPTPRGYRLFVDTMLTVEAPIDAEAVARQVQNTLQAGEPQQRVVAAAASVLSNLSQFAGVVLTPRRSHVFKQIEFMRLSDKRILLIIVTPEGDVQNRMLATPRDYTPSQLTEASNYINAHFAGLSFDEVRRRLRDEIDQLRGDMTTLMHAAVTASTEVPDTEDTVLISGERNLLEVADLSSDMARLRKLFDVFDQKTGLLQLLDVSSHAQGVQIFIGGESTLVPIEEMSVVTAPYEVNGKIVGTLGVIGPTRMAYNRVIPIVDITARLLSLALSQQ
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: RN148_HUMAN
Sequence: MSFLRITPSTHSSVSSGLLRLSIFLLLSFPDSNGKAIWTAHLNITFQVGNEITSELGESGVFGNHSPLERVSGVVALPEGWNQNACHPLTNFSRPKQADSWLALIERGGCTFTHKINVAAEKGANGVIIYNYQGTGSKVFPMSHQGTENIVAVMISNLKGMEILHSIQKGVYVTVIIEVGRMHMQWVSHYIMYLFTFLAATIAYFYLDCVWRLTPRVPNSFTRRRSQIKTDVKKAIDQLQLRVLKEGDEELDLNEDNCVVCFDTYKPQDVVRILTCKHFFHKACIDPWLLAHRTCPMCKCDILKT
What are the official names of this protein?
RING finger protein 148.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS4_CORA7
Sequence: MARYTGPATRVSRRLRVDLVGGDMAFERRPYPPGQAGRNRIKESEYLLQLQEKQKAKYTYGVLERQFRRYYAEANRLPGKTGDNLVVLLESRLDNVIYRAGLANTRRQARQLVSHGHFTVNGKKINVPSFRVTQYDIIDVRERSQKMEWFEEAQDRLVDANVPAWLQVVPDTLRILVHQLPERAQIDVPLQEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: GLYA_SALPC
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAQGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDEMAKLAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGDEELYKKLNSAVFPSAQGGPLMHVIAGKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRIGSPAVTRRGFKEAEVKELAGWMCDVLDNINDEATIERVKVKVLDICARFPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM2D3_CAEEL
Sequence: MRQLLLTLSLISVSASDATVKCDDLDPNQYLCKNYAVDTITQQSVTCAADNSIQVMCETAEHIKCVGKDQFGIFNRTVPSACHYGAHVSYTTTVLLSIFLGFFGIDRIYLGYYALGLIKMFSLGGLFVFWLVDIILISLQLLGPADGTAYAMAYYGPKAQMIRFDSHTNFSFYTCDGCL
What are the official names of this protein?
TM2 domain-containing protein Y66D12A.21.
What is the protein family that this protein belongs to?
Belongs to the TM2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KLH17_MOUSE
Sequence: MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPAPEAERARPRQARPAAPMEGAMQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL
What is the function of this protein?
Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes.  The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6.  May play a role in the actin-based neuronal function (By similarity).
What are the official names of this protein?
Kelch-like protein 17, Actinfilin.
What are the subcellular locations of this protein?
Postsynaptic density. Synapse.
Protein: MSMB2_PROFL
Sequence: MRVFFSLIIFSFMLATCQGACGIGPLVSSPTDAMAPKKCVDPNDRRKHLIVSTWNTADCLRCECDNDGLSCCHRYGGLAERAGCKSVLNQVTCEYEFYRLDDLSKRCDA
What is the function of this protein?
May serve as a self-defense protein against the toxic effects of the snake venom during accidental envenomation.  Does not show inhibitory activity towards brevilysin H6.
What are the official names of this protein?
Small serum protein 2, SSP-2.
What is the protein family that this protein belongs to?
Belongs to the beta-microseminoprotein family.
What are the subcellular locations of this protein?
Secreted.