PharMolix/UniProtQA huggingface dataset:
Protein: RFCS_NATPD
Sequence: MSEGDADGGGREIWIEKYRPQTLDDIVGHESITERLKQYIAQNDLPHLLFAGPAGVGKTTAATAIAKEVYGDDWRENFLELNASDQRGIDVVRDRIKSFARASFGGYDHRIIFLDEADALTSDAQSALRRTMEQFSDNTRFILSCNYSSQIIDPIQSRCAVFRFSPLGDAAVDEQIRIIADTEGIELTDDGVDALVYAADGDMRKAINGLQAAAVMGGTVDEEAVYTITSTARPEEIREMVTEAMDGDFTAARSQLETLLTDVGIAGGDIIDQLHRSVWEFDLEEREAVQLMERIGEADYRITAGASEQLQLEALLAALARGNET
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C small subunit, RFC small subunit, Clamp loader small subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: PLBL3_CAEEL
Sequence: MKLLFFLFGLIFAVEQEKPYLDNNRVPVEQILNDHSSAKFDYTYVSVCVNSTDETLLDIVYAKECKNAASRVALGKYSNQVNTTGWGILEIETFASHSYDVQAYGAGVAEGELTRLQIYYHYRNTIETMCNNHTLFCKRLYIYLQQNLDWMRSQVQANPPTDPFWRQVNLTFAQLTGIYDAYSKRNLTPEIGFDLHPIYMMQLAGDMFDLNKLLNKTADPMEYPEGGRCSGFVKLAPGNKDMFMAHVSMSSLSWMQRVLKIYKFGYDVNEVPGHIVTFSGYPGVLISTDDYTITSAGLTSIETTIAIFNQTLYTDKFMKPEGQVHCWIRSMISNLLSRTGKQWVDMFGRYNSGTYNNQWTVLDWKQFTPEKELPDKDVLWISEQTPGYYETRDMTWYLKKYTYFASYNIPFLPKVSEISGFDNKARQFAWFDWGGSPRARIFDRDHSKVTDIDSLTKLMRYNDYTHEEFARCKCTPNPYTGEGGISARGDLNTPGGTYEVESMGFRDHAGLDFKGTNYEMFKKMRFRAWGGPPYDPLPVFDWNHTNLTNVRHFGQPDVWNFTYVDLEWQLAAQVQLTPYDN
What is the function of this protein?
Putative phospholipase.
What are the official names of this protein?
Putative phospholipase B-like 3, LAMA-like protein 3, Lamina ancestor homolog 3.
What is the protein family that this protein belongs to?
Belongs to the phospholipase B-like family.
What are the subcellular locations of this protein?
Secreted.
Protein: SAU22_ARATH
Sequence: MALVRSLLGAKKILSRSTAAVSAAPKGFLAVYVGESQKKRYLVPLSYLNQPSFQALLSKSEDEFGFDHPMGGLTIPCHEDTFINVTSRLQ
What is the function of this protein?
Functions as positive effectors of cell expansion through modulation of auxin transport.
What are the official names of this protein?
Auxin-responsive protein SAUR22, Protein SMALL AUXIN UP RNA 22.
What is the protein family that this protein belongs to?
Belongs to the ARG7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YKOF_BACSU
Sequence: MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKTDHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKRVNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDAHDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG
What is the function of this protein?
Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine.  Could also transport other HMP-containing products.  Binds thiamine via its HMP moiety.
What are the official names of this protein?
Putative HMP/thiamine-binding protein YkoF.
Protein: H2A4_VOLCA
Sequence: MAGRGKGKTAGKKAVSRSSKAGLQFPVGRIARYLKKGKYAERIGAGAPVYLAAVLEYLTAEVLELAGNAARDNKKNRIVPRHIQLAIRNDEELGKLLGDVTIASGGVLPNIHAVLLPKKSKGGKGEEAA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A-IV.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DEFB1_CHILA
Sequence: MRIHYLLFAVLFLFLMPVPGEGGIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK
What is the function of this protein?
Has antibacterial activity against Gram-positive bacterium S. pneumoniae Serotype 14.  Is also active against Gram-negative bacteria M. catarrhalis 1857, and non-typeable H. influenzae strains 86-028NP and 1128.  Has antifungal activity against C. albicans.  May have a role in maintaining sterility in the middle ear (PubMed:14996845).  May act as a ligand for C-C chemokine receptor CCR6.  Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner.  Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (By similarity).
What are the official names of this protein?
Beta-defensin 1, BD-1, Defensin, beta 1, cBD-1.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles.
Protein: Y678_STAA1
Sequence: MTHIIIDGDACPVVDSIIDLTTETGIFVTIIRSFSHFSNQLYPPHVSTLYVDDGPDAVDYKIVQLSTKDDIVVTQDYGLASLLVDKVLIVMHHNGKIYNSKNIQQLLDKRYINAQIRKQGGRHKGPPPFTKQDQKVFEQSLLKVIHRIKELD
What are the official names of this protein?
UPF0178 protein SAHV_0678.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: RS10_PROA2
Sequence: MAVQQKIRIKLKSYDHSLVDKWAVKIIDVVKQTDAIIFGPIPLPTKSHVYTVNRSPHVDKKSREQFSFSSHKRLIEIMNPTGKTIDMLMKLELPSGVDVEIKS
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RUVC_SYNP6
Sequence: MGQRILGLDPGLAIVGFGALLCPDSRQGSLELLDFGVISTPAGAEIGDRLETIYQDLHQLIDLVQPDAVAVEKLFFYRMGNTIAVAQARGVLMLVLRQRRLPYCEFTPAQVKQALTGYGNAPKLAVQQAVQRELQLDAIPRPDDAADAVALALTAWFQQLA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: LRC59_XENTR
Sequence: MARANGRSQNLRDKLDGNELDLSLSDLSEVPVRDLVAIPKATALDLSCNKLTSLPDDFCNLSYIVRLDLSKNQIAQLPSEFGRLVNLQHLDLLQNRIVALPVSFAQLKSLKWLDLKDNPLKPALAKVAGDCLDEKQCKECAQGVLQYMKSVQSDHERELQRKLQLDKDRKQRLEAQQRVKEEQDRELRKRMKQQQKERKRRDYNAMQEAQKALNNNKKKAEEEPSENHKPVPTPKEKKLARRQSRLRKIACILLFGLMVALLGVVACRFTDLKTFEVCRSVNAVYKETLSALHSNPVLERFLQDPSSQ
What is the function of this protein?
Required for nuclear import of FGF1.
What are the official names of this protein?
Leucine-rich repeat-containing protein 59.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery.
Protein: RL7_MYCVP
Sequence: MAKLSTDDLLDAFKEMTLLELSEFVKQFEETFDVTAAAPVAVAAAGPAAGGAAAEAAEEQSEFDVVLESAGEKKIGVIKVVREIVSGLGLKEAKDLVDSAPKPLLEKVNKEAAEDAKGKLEAAGATVTVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PGK_BART1
Sequence: MVFRTLDDVDVLGKRVLVRVDFNVPMALGKVCDETRLVRHKETLVELQKRGAKLILLSHCGRPKGKIEPEFSLRPVVSVLEKIINQPVAFAPDCIGSTVQVAVEALQNGDVLLLENVRFYAGEEKNDCSFAGALAHNGDLYVNDAFSVSHRAHASVEGITRLLPSYAGRSLQGELQALEKGLGNPTRPVVALVGGAKVSSKLFVLNHLVEKVDTLVIGGGMANSFLAAQGIHVGKSLCEHTLMETVKKIIKKAQECHCTLLLPVDVVVGFRFEKDAPHRLYDIGDIPEEGMILDIGTRSIVHINSVIDKAATLVWNGPLGVFEMPPFDKGTIAVARHAAERSLTGRLVSIAGGGDTVFALNHADVANDFTYLSTAGGAFLEWMEGKVLPGILALMQP
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_NITEC
Sequence: MVHPLFRHAEFYTTVNHIKDLPQATGVEIAFAGRSNAGKSSAINTLVGRGRFAFTSKTPGRTQHINFFQLGEERFMVDLPGYGYAQVPLAIRQHWVHLLSTYLQTRQALYGMILIMDIRHPLTKLDLQMLEWFAQTGKLVHVLLTKADKLSRSKALAVLDEIRQFLSTSYSGCTVQIFSSLTSEGAEEASRLLQDWFDEGGARVQQLNDSEISNQKKTPAKGD
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: MYLIA_DANRE
Sequence: MLCHVTRPDAVVMEIEVDAKANGEDCLNKVCRKLGIIEVDYFGLQFSGSKGENLWLNLRNRISQQMDNLTPCRLRLRVKFFVEPHLILQEQTRHLFFMHVKEDLHRGHLRMCSEQAQELSALLAQAEFGDYNQNTAKYWYTELCGSEPNQTTINSIIAKHKALEGLSQASVEYQALQLVSSLEHYGVEWHWARDAEAQRLAIGVGPEGIAICRDDFSLVNRISYPIIQIATQSGKSVYLTVTKESSDSVVLLFKLISNRAASGLYRAITETHAFYRCDTVTNAVMMQYSRDFKGHLASLFLNENINLGKKYVFDIRRTSKEVYDYARRALYNAGIVDMMSRPGERTPSNRSPSREQEGALDCGGCQQSRLLQEKLQKLREALLCMLCCEEEIDAAFCPCGHMVCCQNCAAQLQSCPVCRSEVEHVQHVYLPTCTSLLNLTIGENSPEPIHRGMAAHTCTTNDYSTSEKIYQN
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity).  Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway.
What are the official names of this protein?
E3 ubiquitin-protein ligase MYLIP-A, Myosin regulatory light chain-interacting protein A, MIR-A, RING-type E3 ubiquitin transferase MYLIP-A.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PHNW_PHOV8
Sequence: MRPYLLLTPGPLTTSESVKTAMMTDWCTWDEDYNVHIVEEIRKGLVQLATRKTDEYTSILMQGSGTYCVEATLGSVITPKHKLLILSNGAYGDRMGNIAEYHEMNYDMLAFDETEQVSVEYVDDYLAHNAEITHVAVVHCETTTGILNPLKEIAHMVKMHGKKLIVDAMSSFGGVPLDVEELGIDFMISSANKCIQGVPGFGFIIARKSELQYCKGVSKSLSLDIYDQWDAMEKGHGKWRFTSPTHVVRAFKQAMDELAAEGGVEARHARYCRNHDVLVEGMRSLGFKTLLKDEVQSPVITSFLYPDKEFDFKEFYHQLKEKGFVIYPGKISQADTFRIGNIGDVFPEDFSRLIEAIKTVAK
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase, 2-aminoethylphosphonate aminotransferase, AEP transaminase, AEPT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: HEMA_BRV1
Sequence: MLSLILFFPSFAFAATPVTPYYGPGHITFDWCGFGDSRSDCTNPQSPMSLDIPQQLCPKFSSKSSSSMFLSLHWNNHSSFVSYDYFNCGVEKVFYEGVNFSPRKQYSCWDEGVDGWIELKTRFYTKLYQMATTSRCIKLIQLQAPSSLPTLQAGVCRTNKQLPDNPRLALLSDTVPTSVQFVLPGSSGTTICTKHLVPFCYLNHGCFTTGGSCLPFGVSYVSDSFYYGYYDATPQIGSTESHDYVCDYLFMEPGTYNASTVGKFLVYPTKSYCMDTMNITVPVQAVQSIWSEQYASDDAIGQACKAPYCIFYNKTTPYTVTNGSDANHGDDEVRMMMQGLLRNSSCISPQGSTPLALYSTEMIYEPNYGSCPQFYKLFDTSGNENIDVISSSYFVATWVLLVVVVILIFVIISFFC
What is the function of this protein?
Structural protein that makes short spikes at the surface of the virus.  Contains receptor binding and receptor-destroying activities.  Mediates de-O-acetylation of N-acetyl-9-di-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells.  Also hydrolyzes 5-N-acetyl-4-O-acetylneuraminic acid and N-acetyl-9-O-acetylneuraminic acid, but displays a substrate preference for N-acetyl-9-di-O-acetylneuraminic acid.  This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell.  May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one.  Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture.  However, its presence in the virus may alter its pathogenicity.  May become a target for both the humoral and the cellular branches of the immune system.
What are the official names of this protein?
Hemagglutinin-esterase, HE protein, E3 glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface (By similarity).
Protein: DER_AZOVD
Sequence: MVPVIALVGRPNVGKSTLFNRLTKTRDAIVAEYAGLTRDRQYGEAKWQGRTYIVIDTGGISGDEEGIDAKMAEQSLQAIEEADAVLFMVDSRAGMTAADQLIAEHLRKRNKRSFLVANKVDTVDPDIARAEFSPLGLGDALPIAAAHGRGINAMLEAALGIFPRDDEGEEGEGEAEVVAEGEEPKRVPGPSEKDGIKIAIIGRPNVGKSTLVNRMLGEERVIVYDQAGTTRDSIYIPFERDEDKYTLIDTAGVRRRGKIFEAVEKFSVVKTLQAIQDANVVIFVMDAREGVVEHDLNLLGFVLETGRALVIALNKWDGMEPGQRDYVKIELERRLMFADFADIHFISALHGTGVGHLYKSVQAAFQSAVTRWPTSRLTRILEDAVQEHQPPLVNGRRIKLRYAHLGGANPPLIVIHGNQVEAVPKAYTRYLENTYRRVLKLVGTPIRIEYKGGDNPYEGKKNSLTERQVNKKRRLMSHHKKAEKKRRDKKR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: MSRP_ECOLI
Sequence: MKKNQFLKESDVTAESVFFMKRRQVLKALGISATALSLPHAAHADLLSWFKGNDRPPAPAGKALEFSKPAAWQNNLPLTPADKVSGYNNFYEFGLDKADPAANAGSLKTDPWTLKISGEVAKPLTLDHDDLTRRFPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNAKYVAFETIYAPEQMPGQQDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRERPPTTWNLAAPDEYGFYANVNPYVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYAAQVASLYRGLDLRENF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons (PubMed:26641313).  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine (PubMed:26641313).  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal (PubMed:26641313).  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide (PubMed:26641313).  Can catalyze the reduction of a variety of substrates in vitro, including dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide (PubMed:15355966).  Cannot reduce cyclic N-oxides (PubMed:15355966).  Shows no activity as sulfite oxidase (PubMed:15355966).
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: CH60_LIMF3
Sequence: MAKELKFSEDARSAMLRGVDKLADTVKTTIGPKGRNVVLEQSYGSPTITNDGVTIAKSIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVTEGMKNVTAGANPVGIRRGIEKATAAAVEGLKKMSHDVKTKDDIAQIASISAANKEVGKLIADAMEKVGNDGVITIEDSRGVDTSVDVVEGMSFDRGYMSQYMVTDNDKMEANLDNPYVLITDKKISNIQDILPLLQSVVQEGRALLIIADDITGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAQLEDIAVLTGGTVISDDLGMQLKDATIDQLGSANKVTITKDATTIVDGSGNKEAIAERVDQIKKAIAETTSDFDKEKLQERLAKLAGGVAVVKVGAATETELKEKKYRIEDALNATRAAVQEGFVPGGGTALVNVIPALDEVEASATGDEATGIKIVKAALEAPVRQIAENAGLEGSVIVNQLKQEKPGVGYNAADDKFEDMVAAGIVDPTKVTRSALQNAASVSALLLTTEAVVADKPQPADAAPQAPVAGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_OLEA2
Sequence: MKGLRKLLLVLGVMLLATGVALAAGGEAASGEHHYDWTNLGFRLANFAIFIAIIYYAAGKKLIAFFGGRRKGIEQELNDLETRKTDAKKQLGDVEKRIADLENERKAIIAEYQAQGEALKAAIISKAETSARQIVEQAKKSAENEVKYAKDAMREELADMIVDATEKLLKERLDGKEQEKLIDKYLTKVVLN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CDIP1_BOVIN
Sequence: MSNDPPPPYPGGPTAPLLEEKSGAPPTPGRTSPAVMQPPPGMSLPPADIGPPPYEPPGHPMPQPGFIPPHVNADGTYMPSGFYPPPGPHPPMGYYPPGPYPPGPYAGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC
What is the function of this protein?
Acts as an important p53/TP53-apoptotic effector.  Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
What are the official names of this protein?
Cell death-inducing p53-target protein 1, LITAF-like protein.
What is the protein family that this protein belongs to?
Belongs to the CDIP1/LITAF family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NS1_LDCPR
Sequence: MKQLFAFPLTYQSRKHEKHVAQYAHDLIMRENRLIPMHDLNSAIQLSTDYAKALDQFDLSMYFRLAYAAPFLSRRALWIASSNEHIKDLDHHLASIRTCAVYIAEQDFKQATRSITKNVYFTDIAVHNMQFPFEFDNSYTTAYKNALQTLTTIMYSPAETVFLPLKCFPFCNILMRGYSRETSLCMSPNALFELNQTVYATDFLSMTAFDFQQAVFRSNYDLLKLCGDVESNPGPTTWSSLSVEAITLCAPIKIPSDDEVKSLLPTLFSSDKVYNIFKEYDIIDPSDSVQTMTLFNTLRSKGEAFSKLSEQFSLTDVLNTANRFKVSEKLVMSIAFGMNIVVIDHENNQAYLTRTCNTDQTLFLLISKEIGSDSVSVPFVGEDGDHLRYVSRVTLTSEISHALFPGEALKPVDGSTFFESPTLDVFYEMSYDYGIDELVQLLIPNKYDISMIRSKLDVPRTPWSRFDVLNRKNPTYPPRPQPYGMGPMNGEQAKEYAKASIRIFNTACPEHKIAIPVIYTDDEIVSSNKSSRYYYPTSHAGTSIINHKQCVTDNKQLAPLFGSTPKKLFSKYVSQTNGVFLLMRVYVRELDNDVFDSGVIYVTLHVGNDGIGTHIILTTSYLERIGQSMLVNHVYKIRRADGKYDFQFLEVEGLVSDDEKHRDMLQEICSENDDVIKALYQQINKTEREISRQIGNVLKEHDSVNGRAIMKRADFRLVMHETDEVRSKQISVSVHRFKVLQIPVFTHIVTVKSEIEYGIPLFVRDALIPRIKRRLTSTKQEQHLSSDEAYEINASYRTGCKAVMSLLVEGDLVRLPCGMITTVDNPILHKHSCTLGLHALTGSATGPKKLRIHSAFKCSKCHKVYNNNILAQRCVRAHLGI
What are the official names of this protein?
Non-structural protein 1, NS1.
Protein: TSAD_TRIV2
Sequence: MTTVLAIETSCDETAVAIVNNRQVCSSIIASQIPVHQQYGGVVPEVASRAHLETINDAIAQAMDQAQLGWDKIDGIAATCAPGLVGALLVGLTAAKTLAILHNKPFLGVHHLEGHIYATYLSEPTLDPPFLSLLVSGGHTSLIYVKECGRYESLGETRDDAAGEAFDKVARLLKLGYPGGPVIDKLAQTGNSQAFALPEGKVSLAGGGYHPYDGSFSGLKTAVLRLVQQLERDGDPLPIEDISASFQATVAKALTKRAIACALDYGLDTIAVGGGVAANSGLRQHLQAAATANNLRVLFPPLKFCTDNAAMIACAAADHLSRGHLSPITLGVESRLSLSQVMKLYQ
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1374_PARL1
Sequence: MNISKFEQRTLHALARGGLIRVEKDDKGKIHTATCVTREGWLLADCTVATFRRLRKRRLIASKDGSPYRITREGLHAVRAQLDNR
What are the official names of this protein?
UPF0386 protein Plav_1374.
What is the protein family that this protein belongs to?
Belongs to the UPF0386 family.
Protein: URE1_SPOPA
Sequence: MKINRQQYAESYGPTVGDQVRLADTDLWIEVEKDTTYGDEAVNFGGGKVLREGMGENGTYTRTENVLDLLLTNALILDYTGIYKADIGVKDGYIVGIGKGGNPDIMDGVTPNMIVGTATEVIAAEGKIVTAGGIDTHVHFINPDQVDVALANGITTLFGGGTGPAEGSKATTVTPGPWNIEKMLKSTEGLPINVGILGKGHGSSIAPIMEQIDAGAAGLKIHEDWGATPASIDRSLTVADEADVQVAIHSDTLNEAGFLEDTLRAINGRVIHSFHVEGAGGGHAPDIMAMAGHPNVLPSSTNPTRPFTVNTIDEHLDMLMVCHHLKQNIPEDVAFADSRIRPETIAAEDILHDLGIISMMSTDALAMGRAGEMVLRTWQTADKMKKQRGPLAEEKNGSDNFRAKRYVSKYTINPAIAQGIAHEVGSIEEGKFADLVLWEPKFFGVKADRVIKGGIIAYAQIGDPSASIPTPQPVMGRRMYGTVGDLIHDTNITFMSKSSIQQGVPAKLGLKRRIGTVKNCRNIGKKDMKWNDVTTDIDINPETYEVKVDGEVLTCEPVKELPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCAP_I00A0
Sequence: MASQGTKRPYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGATVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVAPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMENARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYEN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.