PharMolix/UniProtQA huggingface dataset:
Protein: SURE_YERPP
Sequence: MIRILLSNDDGISAPGIQTLASALRGFAQVQIVAPDRNRSGASNALTLDSALRITTLSNGDIAVQQGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGYPALAVSLNGHQHYDTAAAVTCRLLRALQRKPLRTGKILNINVPDLPLAEIKGIRVTRCGSRHPAEQVFCQQDPRGQDLYWIGPPGEKYDAGPDTDFAAVEQGYVSITPLQVDLTAYMAQEVVESWLANTEVDGEW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UFC1_DROSI
Sequence: MVDDSTRKTLSNIPLLQIRAGPREKDVWVQRLKEEYQALIKYVENNKQSGSDWFRLESNKEGTKWFGKCWYMHNLLKYEFEVEFDIPVTYPTTAPEIALPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGIAHAMALGLAPWLAVEIPDLIEKGIITYKEK
What is the function of this protein?
E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.
What are the official names of this protein?
Ubiquitin-fold modifier-conjugating enzyme 1, Ufm1-conjugating enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
Protein: COAD_STRCO
Sequence: MRRAVCPGSFDPITNGHLDIIARASSLYDEVYVAVMINQAKKGLFEIEERIDLIRRVTAEYGNVRVESFHGLLVDFCKQREIPAIVKGLRAVSDFDYELQMAQMNNGLSGVETLFIPTNPTYSFLSSSLVKEVATWGGDVAHLVPPLVLEALTERLRNR
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DF159_ARATH
Sequence: MAKLSCSYFLVLILVFSAFLMVERAEGKRCHLTIDKATACSLSDCRLSCYSGYNGVGKCFDDPKVAGPSNCGCIYNC
What are the official names of this protein?
Defensin-like protein 159, Low-molecular-weight cysteine-rich protein 25, Protein LCR25.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: WHIA_PSECP
Sequence: MALTASVKEELSRLDIKKSSVRKAEVSAMLRFAGGLHIISGRIVIEAEVDLASTARRLRAAIAEVYGHQSEIIVVSAGGLRRASRYVVRVVRDGEALARQTGLLDGRGRPVRGLPSAVVNGSAADAEAVWRGAFLAHGSLTEPGRSSSLEVTCPGPESALALVGAARRLDIQAKAREVRGVDRVVIRDGDTIAALLTRMGAHDALMVWEERRMRKEVRATANRLANFDDANLRRSAQAAVAAGARVDRALEILGDDVPDHLKYAGELRVAHKQASLDELGRLADPVMTKDAIAGRIRRLLAMADKRALDLGIPGTDANVTPEMLDE
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: RIBBA_STAAS
Sequence: MQFDNIDSALMALKNGETIIVVDDENRENEGDLVAVTEWMNDNTINFMAKEARGLICAPVSKDIAQRLDLVQMVDDNSDIFGTQFTVSIDHVDTTTGISAYERTLTAKKLIDPSSEAKDFNRPGHLFPLVAQDKGVLARNGHTEAAVDLAKLTGAKPAGVICEIMNDDGTMAKGQDLQKFKEKHQLKMITIDDLIEYRKKLEPEIEFKAKVKMPTDFGTFDMYGFKATYTDEEIVVLTKGAIRQHENVRLHSACLTGDIFHSQRCDCGAQLESSMKYINEHGGMIIYLPQEGRGIGLLNKLRAYELIEQGYDTVTANLALGFDEDLRDYHIAAQILKYFNIEHINLLSNNPSKFEGLKQYGIDIAERIEVIVPETVHNHDYMETKKIKMGHLI
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: BGLM_ASPTN
Sequence: MHSFLGLVGLLAGVSVSSAAPSVQNITSDTYFYGQSPPVYPSPEGNGTGSWAVAYQKAKAFVAQLTSEEKVNLTAGVTSDTGCSGMIPAIPRLNFPGLCVSDAGDGLRGTDYVNSWPSGIHAGASWNKNLARQRAYHMGTEFHKKGVNVLLGPVVAPLGRVVEGGRNWEGFSNDPYLSGALVYETVKGIQSAGVGACTKVRFPQRLQSSGSNLVQHFTGYEQETNRNPETVDGVDIASVSSNIDDKAMHELYLWPFQDAVHAGSVSVMCSYQRINNSYACQNSKTLNGLLKTELGFQGYVMTDWYGQHGGIAAANAGLDMVMPYTELWGSNLTDAISNGTMEASRLDDMATRIIASWYQVNQNKNFPAPGIGMPADVNEPHQAVIGKSPDSRTTLLQGAIEGHVLVKNTKQALPLQSPRLLSVFGYDAKAGDSLIVNDVSFVNASVQKNHTLYVGGGSGTNSAAYVLAPLDAVQQQAYEDGTSVLWDVVSEDPDVDATTDACLVFINAYATEGYDRPGLVNKESDTLITNVAGKCNNTIVTIHNAGIRLVGDWINHENVTAVIFAHLPGQDTGKALVELLYGRANPSGRLPYTVAKRAGDYGSLLHPSQPEGKYGLFPQSDFSEGVFIDYRAFDKQGIEPQFEFGFGLSYTSFNYSGLAVKKVNRTTEPYPASAPVQEGGNPNLWDEILTVSAKVQNSGSMDGDEVAQLYLGIPNAPVRQLRGFEKVGIPAGQAVNVKFSLTRRDLSVWDTEAQQWKLQSGDYQVYVGRSSRDLPLKGQFSI
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase M, Beta-D-glucoside glucohydrolase M, Cellobiase M, Gentiobiase M.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RBFA_ACTP7
Sequence: MSREFKRSDRVAQELQKEIAVILQREVKDPRIGMVTVSDVEVSRDLAYAKIFVTFLFDNDQSVIEQGMKGLEKASPYIRSLVGKAMRLRIVPELRFIYDQSLVEGMRMSNLVSNVIKNDEAKHKEEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLCE_CAEEL
Sequence: MKCLRWRSNRHRIYLLVACGALFLLNRHLTQEESRIDEEDEELTQVDVNEDDKKIECEPPGSIESKCIADNGKSMKCWKDEEDVYFPVSYLKKRFDMTGKLGKDGSTFELYTSYAKMRSPDSTYDPLGPFGHFSTYSVETRDRVRCVSAKTDVPMSTQWDPIPYYYPIQISQYGLQHYSRMKLDSISNKSEASPKDDVILGVNSKEWKGAAGMHETTERLFFNDEQMGKVVNISAGAALANAGAYVYLDKSPDLHVISFDWKPYEANSSFTVLAKMKQDDLLVLINYVYSEGNGKCVWQEEERISDDYIVQKPKKDGQVSYSYSYIGNSPIGEWSTVTRDLLVDVARALSSGDNRKKDDNVVLHAGDLRLVSLGFRGELTVKQKITQRREQHSHAFYAAADWLVKNQNDRGGWSVPVERSIAERKLVLPPGWHSAMAQGHGISVLTRAFKHFNDEKYLKSAAKALKLFKINSSDGGVRGEFFGNIWYEEYPTTPGSFVLNGFLYSLIGLYDLSQLELMIDENDETMRAKIQEAQELYSAGVRSLKQLLPLYDTGSGTIYDLRHVALGTAPNLARWDYHAVHVYLLKWIAGIEKDEVLSKTADRWIGYAYGKRAKHN
What is the function of this protein?
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acids (By similarity).  Plays a role in the early migration of AQR and PQR neurons, which descend from the Q neuroblasts (PubMed:26022293).
What are the official names of this protein?
D-glucuronyl C5-epimerase, Heparan sulfate C5-epimerase, Hsepi, Heparin/heparan sulfate:glucuronic acid C5-epimerase, Heparosan-N-sulfate-glucuronate 5-epimerase.
What is the protein family that this protein belongs to?
Belongs to the D-glucuronyl C5-epimerase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Secreted, extracellular space, extracellular matrix, basement membrane.
Protein: Y1138_METJA
Sequence: MKSVKKLLLLAFAVCLAVGFSGCLEQPKIEVVGQKIQKVDADNTKIEIQVLVDNPNPIGISIDKISFDIYALVGGDKIYLGHGEQSNIKITSGNTTFTLPVTISNKKLVEVALKEKSTKIPIEIKGDIAVNLFITKVNIPIDIQQEIDVSAIAKEEVLNQLNNLNPNQIQSIAQ
What are the official names of this protein?
Uncharacterized protein MJ1138.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS4_PSEPK
Sequence: MARYIGPKCKLSRREGTDLFLKSGVRALESKCNIEAAPGIHGQRRGRQSDYGTQLREKQKVRRIYGVLERQFRGYYQAAASKKGATGENLLQLLECRLDNVVYRMGFGSTRSESRQLVSHKAISVNGKTVNIPSYQVRPGDVVAVREKSLGQLRIVQALELCAQRGRVEWVDVDAAKKSGVFKNVPARSDLSADINENLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SP4B_BACSU
Sequence: MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQAIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLPDLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIEKMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGIGTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLARFSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDDKVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAVTHVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS
What is the function of this protein?
Plays a central role in the sigma-K checkpoint which coordinates gene expression during the later stages of spore formation.  The protease is activated by trans cleavage of the zymogen precursor producing SpoIVB-45 kDa.  This undergoes further trimming by cis cleavage to form SpoIVB-43 kDa and SpoIVB-42 kDa.  The protease then cleaves the C-terminus of the SpoIVFA metalloprotease activating the latter.
What are the official names of this protein?
SpoIVB peptidase, Sporulation factor IV B protease, Stage IV sporulation protein B.
What are the subcellular locations of this protein?
Forespore intermembrane space.
Protein: PGK_HELPJ
Sequence: MLAKMSFMQNVKNIQEVDVNHKRVLIRVDFNVPLDENLNITDDTRIRESLPTIQFCIDNKAKDIILVSHLGRPKGVEEKLSLKPFLKRLERLLNHEVVFSQNIAQLKQALNENAPTRIFLLENIRFLKGEEENDENLAKDLASLCDVFVNDAFGTSHRKHASTYGTAKFAPIKVSGFLLKKEIDSFYQAFNHPLRPLLLIVGGAKVSSKLTLLKNILDLIDKLIIAGAMSNTFLKALGYDVQDSSVEDALINDALELLQSAKEKKVKVYLPIDAVTTDDILNPKHIKISPVQDIEPKHKIADIGPASLKLFSEVIESAPTILWNGPLGVHEKQEFARGTTFLAHKIANTYAFSLIGGGDTIDAINRAGEKDNMSFISTGGGASLELLEGKILPCFEVLDKRH
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_TREPS
Sequence: MGKTVKIRKDDMVLVIAGKDRGKRGAVLRVLRDVDRVLVQGLNMRKKTIRRKSAQDEGGIMEVEAPIHISNVMIMGKKGPTRVGYRMENGKKVRVCRKTGEVL
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CNGA1_CANLF
Sequence: MKKNIINTWYSFVNIPNVIVPDIEKEIRRMENGARSSFSDDDGDDDSASMFEESENETPHARDSCRNNSQRRDPSQREQYLPGAIALFNVNNSSNKEQEPKEKKKKKKEKKSKSGDKNENKKDSEKKKKKEKEKEKKNKEEKGKDKKEEEKKEVMVIDPAGNMYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWIIFDYLSDIVYLLDMFVRTRTGYLEQGLLVREEAKLIEKYKSNLQFKLDFLSVIPTDLLYFKLGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVYFSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDINIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVERFLKPIIDTEFSALEGTGDESRPLDSTQD
What is the function of this protein?
Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway.  When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
What are the official names of this protein?
cGMP-gated cation channel alpha-1, Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, CNG channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel, photoreceptor, Rod photoreceptor cGMP-gated channel subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDP1_ARATH
Sequence: MYKTKLIPVMNEDAVIVQQTDSIQDPKVTPDDTVVDSSGDVHEAIDDDVEASSPMELDSAVTNDARVLESERSEKDGVVGSEEEDEIKSEDVLIDKDDESSEVKEEEEEEDGSDDQSSELGSEADEKELDLGLKEEKKGVSDYKSLLSEFDDYVASEKMGSGVSRALSYGFEVGDLVWGKVKSHPWWPGHIFNEAFASPSVRRMRRIDHVLVAFFGDSSYGWFDPAELIPFEPNLEEKSQQTVSKHFVRAVEEAKDEASRRSALGLTCKCRNPYNFRPSNVEDYFAVDVPDYELQAVYSVDQIKNSRDKFLPAETISFVKQLALAPQECDPDSLKFMKKKAVVFAFRKSVFEEFDETYAQAFGTKSPRSSVSTLEPHNRAPPRAPLSGPLVIAETLGDLKSSKKPTKVKVSKKKDKYLLKRRDEAGDKSVQFGEIEASSEASHIQGIDGSLDGDFGLQRRAPTLQTPMKDEKSGIVSMDFASSNTAIPGKEFSASKPSLDEEKGLAEKSKERMEERAAVLPEHGKSEAMASLKPKEEAGTDLGSAGSSLQPLLESHTSASEGKSSTGSVIKKVKVAKRSSSEMSSENPPSEPKKKKKKKKEPDSDHPVKRKNLYSGEAGAKKLSQLGSAHLQTYMEADVPQLLSHLQDLSLDPFHGLSVASFGTARKFFLRFRSLNYQKSLSVSSSDATVENARDTKPSKPVKTVKRTEDPSKAGKKRLSSDRQDEIPSAKKLKKTNQLKSMASEKKIIREAKDSIKPIREPSRVVQAKPARGQTGKKTAPSVKVVEPTMLVMKFPPGTSLPSAALLKARFGRFGLLDQSAIRVFWKSSTCRVVFLYKADAQTAFRYATGNNTLFGNVNVKYFLRDVDAPKAEPREPENTKEDDEPQSQWLDQAPPLHQPTLPPPNVNLKSCLKKPVDDPSSSSNNGNGNRAAVRVKFMLGGEENSSKANTEPPQVTMTLNRNSGPSSSSSSVPMEFVSKKFQNVVHHQQLPPSTLPPILPLPPQYTKPQQLPIKPVDHVEPPMPPSRNFRGPIPAVSAGDISHQMLNLLSKCNEVVANVTGLLGYVPYHPL
What is the function of this protein?
Together with PDP2, PDP3 and PDP6, interacts with MSI4/FVE and MSI5 to suppress FLC, MAF4 and MAF5 expression by regulating the function of the PRC2 complex and modulating H3K27me3 level, thereby promoting flowering.
What are the official names of this protein?
PWWP domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PDP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHEB_NOSP7
Sequence: MRIAIVNDTAMAVEALKRVLLTVPGHEISWIARDGTEAVARCARDTPDLILMDLFMPVMDGVEATRQIMKQSPCAIIIVTASVSKNAGKVFEAMGYGARDAVNVPILGTQESSDSAQLLLTKIATIAKLIGKSSPTSTPKPQTAKLTSFSTHSTLLPPLVAIGSSTGGPKALAAILSRLPANFGAAIAIVQHVDMQFSAGLVDWLNQQTALTVQLATVGDRFEKGIVLVAGTNDHLSLHSDLTLHYTKEPIDYPYRPSVDVFFKSLAQYWNAKGTAVLLTGMGQDGAQGLSLLRSRGWHTIAQDEKSSVVYGMPKAAVQLNAAVEILPPEAIATSLIQQIMFRKSGVPKSDTRK
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_SACS2
Sequence: MKKWSDTEVFEMLKRMYARVYGLVQGVGFRKFVQIHAIRLGIKGYAKNLPDGSVEVVAEGYEEALSKLLERIKQGPPAAEVEKVDYSFSEYKGEFEDFETY
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: 089L_IIV3
Sequence: MPRDKKLVHRATSDVEDEDNDQREEEWSDNDQPSTKDDTAAPTETGLEPSSASNGHSQPAIVAALEQERRQHLESIILKRTLYLQQQRQKQQEGTNRP
What are the official names of this protein?
Uncharacterized protein 089L.
Protein: UVRB_NEIMA
Sequence: MEVIRYPDSPFKLHQPFPPAGDQPTAIAGLLEGLSDGLAYQTLLGVTGSGKTYTMANVIAQSGRPAIIMAHNKTLAAQLYAEMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSAINEHIEQMRLSATKNLMTRDDVIIVATVSAIYGIGDPTEYQQMVLSVKEGDTIEQRDIIATLVSMQYERGDLDFKRGSFRVRGDVIDVYPAESSENALRISLFDDEIDRLDMFDPLSGSLHQRVGRYTVFPSSHYVTPRDTVLRACDSIKEELRERIDFFTKENRPVEQQRIEQRTRFDLEMLYEMGFCKGIENYSRHFSGKKEGEPPPTLMDYLPSNAIMFIDESHVTVTQIGGMYKGDASRKQNLVDYGFRLPSARDNRPLKFHEFEKVMPQTVFVSATPAKYEEEHAGQVVEQVVRPTGLVDPQIIIRPVATQVDDLMSEINDRIQKGERVLVTTLTKRMAEQLTDYYSELGIKVRYLHSDIDTVERVEIIRDLRLGLFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSHRSLIQTIGRAARNVNGVAILYADKITDSMKAAIDETERRREKQIKFNEEHGIVPQQIKKQVKDIIDGVYHEEDSGKGRRQGKNKVKVGEIHNEEDAIKEIAKLEKAMQQAARDLQFEEAAVLRDRIRNIKENLLFGAE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARRD1_HUMAN
Sequence: MGRVQLFEISLSHGRVVYSPGEPLAGTVRVRLGAPLPFRAIRVTCIGSCGVSNKANDTAWVVEEGYFNSSLSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRAAIHTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASATKKFSYKLVKTGSVVLTASTDLRGYVVGQALQLHADVENQSGKDTSPVVASLLQKVSYKAKRWIHDVRTIAEVEGAGVKAWRRAQWHEQILVPALPQSALPGCSLIHIDYYLQVSLKAPEATVTLPVFIGNIAVNHAPVSPRPGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQRQPLLATLSSVPGAPEPCPQDGSPASHPLHPPLCISTGATVPYFAEGSGGPVPTTSTLILPPEYSSWGYPYEAPPSYEQSCGGVEPSLTPES
What is the function of this protein?
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458).  Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458).  More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426).  By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940).
What are the official names of this protein?
Arrestin domain-containing protein 1, Alpha-arrestin 1.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
What are the subcellular locations of this protein?
Cell membrane. Note=Also found in extracellular vesicles different from exosomes.
Protein: STE14_YEAST
Sequence: MHQDFQEDEHEYPDIRRNPLHEVTMTSYILGILLGIFVGLFPQIRFKNFNLFIIALSLFHFLEYYITAKYNPLKVHSESFLLNNGKSYMAAHSFAILECLVESFLFPDLKIFSYSLATKLCTVLGCLLVILGQYTRTIAMHTAGHSFSHIVKTKKESDHVLVKTGVYSWSRHPSYLGFFWWAIGTQLLLLNPLSLVIFIFVLWKFFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGIPFI
What is the function of this protein?
Mediates C-terminal methylation of the isoprenylated C-terminal cysteine in A-factor mating pheromone and Ras proteins (PubMed:8289819, PubMed:11451995, PubMed:15611058).  Does not have a preference for the farnesyl or geranylgeranyl moieties in the model substrates N-acetyl-S-farnesyl-L-cysteine (AFC) and N-acetyl-S-geranylgeranyl-L-cysteine (AGGC) in vitro (PubMed:15611058).
What are the official names of this protein?
Protein-S-isoprenylcysteine O-methyltransferase, ICMT, Isoprenylcysteine carboxylmethyltransferase, Prenylated protein carboxyl methyltransferase, PPMT, Prenylcysteine carboxyl methyltransferase, pcCMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYI_SALTI
Sequence: MSDYKSTLNLPETGFPMRGDLAKREPGMLARWTDDDLYGIIRAAKKGKKTFILHDGPPYANGSIHIGHSVNKILKDIIVKSKGLSGFDSPYVPGWDCHGLPIELKVEQEFGKPGEKFTAAEFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGRIIKNGHLHKGAKPVHWCVDCRSALAEAEVEYYDKTSPSIDVAFRAVDQDAVKAKFGLPGVSGPVSLVIWTTTPWTLPANRAISLAPDFDYALVQIDGQAVILAKDLVESVIQRIGAAEYTILGTVKGAELELLRFTHPFMGFDVPAILGDHVTLDAGTGAVHTAPGHGPDDYVIGQKYGLETANPVGPDGAYLPGTYPTLDGVNVFKANDIVIELLKEKGALLHVEKMQHSYPCCWRHKTPIIFRATPQWFVSMDKEGLRQQSLKEIKGVQWIPDWGQARIESMVANRPDWCISRQRTWGVPMSLFVHKETQELLPIERTLAAMEEVAKRVEVDGIQAWWDLDPKEILGEDADQYEKVPDTLDVWFDSGSTSYSVVDARPEFAGHAADMYLEGSDQHRGWFMSSLMISVAMKGKAPYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEMAVSDEILKRAADSYRRIRNTARFLLANLNGFNPATDMVKPEEMVVLDRWAVGCAKTAQQEILKAYEAYDFHEVVQRLMRFCSVEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPIMSFTADEIWGYLPGEREKYVFTGEWYDGLFGLEENEEFNDAFWDDVRYIKDQVNKELENQKANGIKSNLEAKVTLKYADDANGTIKKLKLLGEEVRFIFITSQFVISEQAGGIDDENIQYNAGNTTVQAVVTRAEGDKCPRCWHYTTDVGKVAEHADICGRCVSNIAGNGEQRKFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_CALBD
Sequence: MKVSELFMPTLKETPSDAEIESHKLMLRSGFMRQLSSGIYVYLPLGYRVLRKIENIVREEMDRSGAQEVHMSALMPKELWEESGRWAVFGPEMFRIKDRNEREYCLGPTHEEAFTYIVRNEISSYRDLPKILYQIQTKFRDERRPRFGVMRCREFTMKDAYSFDIDENGLDISYQKMYDAYVRIFKRCGLDVKIVEADTGAMGGASSHEFMVPSSVGEAEIAYCKACGYAANLEKAECLDEPVENKEEPKEKQEVYTPNVRTIEELVSFLGIDSTRFVKTMIYKADDKFVAVLVRGDREVNETKLKNLLKATDLELASAEDVEKITGAKVGFAGPIGLSIDVYADNEVKYLKNFVVGANKTDYHIKNVNLSDFKVTKFTDLRNITQDDLCPKCRSQKVTIERGIEVGHIFKLGTKYTQAFNCVYTDEKGEKKLMIMGCYGIGINRTAAAIIEQMHDEDGIIWPITVAPYEVIIVPVNVKDENQKKIAFEIYENLQRNGVEVLIDDRDERAGVKFKDADLIGIPFRVTVGKKISEGKLEIRNRRTKESFEVEIEKAIEVVINLIREEKAKYQI
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPA_META3
Sequence: MHELSYATSIVNAIMEHITNMEQANKVKKVSKINLEIGELTFINFEQLKFAFEVASEGTLCKDAKLEAEFLKPHIACNNCGYRGELTANDEFEVKCPECGSLSLKISGGKEFNIKNAILESDE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.