PharMolix/UniProtQA huggingface dataset:
Protein: HLDE_YERPA
Sequence: MKVTLPDFRRAGVLVVGDVMLDRYWYGPTCRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGAVARLVGLTGIDDAARALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGALNSVQPMIQLARKANVPVLIDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQGMTLLQLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGTSTVSPIELENAIRGRAETGFGVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQRMVVLGALEAVDWVVPFEEDTPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGRG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: PSBA_NICPL
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAIEAPSTNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NIT_HYPVG
Sequence: MPDRVVRVAVTQAEPVWLDLQATIEKTCRLITEAASNNAQLVAFPETWIPGYPCWIWSRLVDFDLNVAYIKNSLRVDSPEMERLQACAREAGIAVSLGFSENSNNSLYISNVLIGSDGEIKVHRRKMKPTHMERTVFGDASGHCLQSVAQLPFGRVGSLSCWEHIQPLLKYNTITQNEEIHVAAWPPLNSEVGDEIPWSMTAEGCKTLSRTYAIESGTFVLHCTAVISESGINSLGTLGGALMSTPGGGHSTIFGPDGRRITDHIEETSEGIVYANLDMDELVVNKMFADCTGHYSRPDLLWLGVSQEIKPVVRPQRAEVDKGTNDQVE
What is the function of this protein?
Nitrilase that hydrolyzes preferentially phenylacetonitrile and heteroaromatic nitriles, but has significantly lower activity for (R,S)-mandelonitrile.  Also acts on dinitriles like phenylenediacetonitriles (PDAs) 1,2-PDA, 1,3-PDA, and 1,4-PDA, and cyanophenyl acetonitriles (CPAs) 2-CPA and 4-CPA.
What are the official names of this protein?
Arylacetonitrilase, NitTv.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Protein: TPIS_PROMS
Sequence: MRKSVIAGNWKMHMTCAEAKSYLKEFIPLIKDINEDRKVVIAPPFTAISTFSNHSDFDYLDISSQNIHWEDQGAFTAEISPKMLLEHGVSYAIVGHSEPRKYFSESDEQINKRAVFAQSSGLTPIVCVGETLEQRERGEAVRVITRQVEQGLENTDPSNLIVAYEPIWAIGTGKTCQAEDANKICSLIRKLIGFDDVIIQYGGSVKPNNIDEIMSMSDIDGVLVGGASLDPNSFARIANYQ
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG67_BPML5
Sequence: MRPSLYDQIVAILDRHDSCCGFERDDAAEELHALVIELYGPPF
What are the official names of this protein?
Gene 67 protein, Gp67.
Protein: P5F11_XENLA
Sequence: MYSQQPFPAFAFNAGLMQDPANCHFGGYTGLGHPQPFSFAFSTLKSENGESGVQGMGDCTTPVMPWNSLASFDHQVQMENNQQGNPPRAPSPTLSDSRIKVKEEVVHETDSGEESPEPKYPSPPNPSLYYPNAWTGAPFWQVNPTPGNNINPMPNQTLVKNTSLPGNTTYPTPANQSPNTPVDCVTSSMESSRCSSTNSPNGAINERATTIPNGEMLDGGQSSDNEEEVPSESEMEQFAKDLKHKRVSLGYTQADVGYALGVLYGKMFSQTTICRFESLQLSFKNMCQLKPFLERWVVEAENNDNLQELINREQVIAQTRKRKRRTNIENIVKGTLESYFMKCPKPGAQEMVQIAKELNMDKDVVRVWFCNRRQKGKRQGMPTVEENDGEGYDVAQTMGSPPVGHYALQQVVTPQGYMAAPQIYASAFHKNDLFPQTVPHGMAMGGHIG
What is the function of this protein?
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').  Activates transcription when directly bound to the octamer DNA sequence, but can form repression complexes with other proteins at the promoter site to inhibit transcription.  Binds to the promoter of the vent2-B gene to activate transcription when in the presence of other BMP signaling factors also bound to the promoter.  Inhibits the competence of ectodermal cells to respond to BMP during embryogenesis thereby inhibiting epidermal differentiation and promoting neural induction.  Antagonizes the activity of nodal/activin signaling by forming a transcriptional repression complex on the gsc and mix2 gene promoters to inhibit their transcription, and thus maintain the undifferentiated state of embryonic cells to prevent them from differentiating prematurely.  Acts maternally to inhibit vegt and beta-catenin-activated gene transcription by forming a transcriptional repression complex on the nodal/nr1 and siamois promoters to inhibit their transcription.
What are the official names of this protein?
POU domain, class 5, transcription factor 1.1, POU class V protein oct-25, XOct-25.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PLGT3_RAT
Sequence: MLGVRRALLLPPLQLALLVAAGTGARVSAPRSLAWGPGLHADAVLPVRYFFLQSVDSDGRNFTSSPPGQTQFKVVVKSLSPKELVRIYVPKPLDRNDGTFLVRYRMHETVHEGLKIEILYGGEHVAQSPYILKGPVYHEYCDCPEDDPQAWQKTLSCPANEPQIEQDFISFPSINLQQMLKEVPKRFGDERGAIVHYTILNNHIYRRSLGKYTDFKMFSDEILLSLARKVTLPDLEFYINLGDWPLEHRKVNDTPGPIPIISWCGSLDSRDIILPTYDVTHSTLEAMRGVTNDLLSVQGNTGPSWINKTEKAFFRGRDSREERLQLVLLSKENPQLLDAGITGYFFFQEKEKELGKAKLMGFFDFFKYKYQVNVDGTVAAYRYPYLMLGDSLVLKQESPYYEHFYVELRPWKHYVPIKRNLSDLLEKVKWAKENDEEAKRIAKEGQLTARDLLQPPRLYCYYYRVLQKYAERQVSKPMIRDGMERVPQPDDSTSVRQCHRKRPEREEL
What is the function of this protein?
Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C.  Can also catalyze the transfer of xylose from UDP-xylose but less efficiently.  Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1.  May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway.
What are the official names of this protein?
Protein O-glucosyltransferase 3, KDEL motif-containing protein 2, Protein O-xylosyltransferase POGLUT3.
What is the protein family that this protein belongs to?
Belongs to the KDELC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RSMG_CLOBJ
Sequence: MEFFNILQSACNDVNLDFNDKKYNQLISYKNLIQEWNKKINLTAIVEDDEIIKKHFIDCIKIFKSSPIGEAKSLIDIGTGAGFPGIPIKILKEDIEITLLDSLQKRINFLNIVIGELQLKNIQCLHGRAEDYAQEIQHRQKYDIAVSRAVANLAVLSEFCIPFVEKGGYFIAMKGPSVEEEITAATKSIEILGGKIEDIMKIDIEDTDLKHNLVIIKKLRETGKRYPRKPGIIKKNPLK
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CISD2_TRIAD
Sequence: MEAIAKLIKVQLPNYLQKLPVPSSLSGFAELSPSDAIAVVFPFAVVSWLIGYSTYKFFQPKAVELPPSPKAKDTNCVNKCIDKTCKKVVHTVDIEDVGEKLVFCRCWRSKKFPYCDGSHNNHNEQEQDNVGPLIVKGKAN
What are the official names of this protein?
CDGSH iron-sulfur domain-containing protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the CISD protein family. CISD2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: SYM_SHEPC
Sequence: MATSQRKILVTSALPYANGPIHLGHMLEYIQTDIWSRYQKLRGHECHYICADDAHGTPIMLKAQQLGLAPEEMIAQVNKEHQQDFADFNIAFDNYHSTHSDENRVLASDIYLKLRTNGYIKSKSISQLFDPEKSMFLPDRFVKGTCPKCKSPDQYGDNCDACGATYSPTELINPKSAVSGATPVMKDTEHFFFDLPAFEGMLKEWTRSGALQTEMANKLDEWFEQGLQQWDITRDAPYFGFEIPDAPGKYFYVWLDAPIGYMGSFKNLCDKRPELSFDEFWAKDSKAEVYHFIGKDIVYFHSLFWPAMLHGSGYRQPNSVYAHGYVTVNGAKMSKSKGTFIKARTYLDHLDPEYLRYYYAAKLSSRIDDLDLNLEDFAQRVNSDLVGKLVNLASRTAGFITKRFDGKLAKIADTTLTEAFLAKQEQIAEFYETREYGKAMREIMALADIANGFVADAAPWQMVKQDDQQEAAHQVCSNALNLFRILVTYLKPVLPRLAQDVEAFFQQTLTWDGLAQDMAGHEISPFKAMMQRVELDKVNAMVADSKENLQVTADVPKTAKPEKTVESSNVSSEPLVDDPISETINFDDFAKIDLRIARIVKAEHVAEADKLLKLQLDIGGETRQVFAGIKSAYSPEDLEGKLTVMVANLAPRKMRFGMSEGMVLAAGPGGSDLWILEPHEGAQPGMRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y0026_MYCTO
Sequence: MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVTSTTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHQNSATAQLDLQVVSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIREVVATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPELPTRAEPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGATPALVPGVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHANEPDERRADDREGADEDAGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQGIAIPLPGTAVANPVDSARISAGDVGVFTATPLPLALAKLFWTARFNTSQPCEGQTF
What are the official names of this protein?
Uncharacterized protein MT0029.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv0025 and Rv0739.
Protein: RRF_BUCBP
Sequence: MERIKNFTSSKMDHCVHMFVNQLNTLRSSRASPSILDTILIDYLGQKIQLKKLSNIIVENVNTLRITLFDPKIKNNVEKAIISSKLDLIPIFINNYFQIKIPVLTEERRLQLIKLAKKMAENSRICIRNIRRLSNEKIKLFLKDKIISSDKERRLQHEVQDITNSYMEKINVILSKKEKDLLK
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCNN4_HUMAN
Sequence: MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
What is the function of this protein?
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990).  Activation is followed by membrane hyperpolarization which promotes calcium influx.  Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614).  Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580).
What are the official names of this protein?
Intermediate conductance calcium-activated potassium channel protein 4, SK4, SKCa 4, SKCa4, IKCa1, IK1, KCa3.1, KCa4, Putative Gardos channel.
What is the protein family that this protein belongs to?
Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CH10_PECCP
Sequence: MNIRPLHDRVIVKRKEVESKSAGGIVLTGSAAGKSTRGEVLAVGHGRILENGEVKPLDVKVGDIVIFNDGYGVKAEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_RHORT
Sequence: MSAGEIDRLIGLLARLPGLGPRSARRAALHLLKRRESLMDPLMEALGAVAASVRLCPVCGTLDTRAPCSICADPRRDGTLICVVRDVADLWALERGGVFSGRYHVLGGLLSAIDGVGPEDLGLDRLAARVAEGPVVEVILALPATVEGQTTAHVIADLIEPKGITVSGLAQGVPVGGELDYLDDGTLTAALRARRPV
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RPOC_PSEMY
Sequence: MKDLLNLLKNQGQIEEFDAIRIGLASPEMIRSWSFGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVALAKVRRERMAHIELASPVAHIWFLKSLPSRIGLLMDMTLRDIERVLYFESYVVIDPGMTTLEKGQLLNDEQYFEALEEFGDDFDARMGAEAVRELLHAIDLDHEIGRLREEIPQTNSETKIKKLSKRLKLMEAFKDSGNLPEWMVLTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLSAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPTLRLHQCGLPKKMALELFKPFIFGKLEMRGLATTIKAAKKMVERELPEVWDVLAEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTREAVNAKGEGRVFADLQEVDRVFRAGEASLHARVKVRINETVKEKDGSITKNTRIVDTTVGRALLFQIVPAGLSYDVVNQPMKKKAISKLINQCYRTVGLKDTVIFADQLMYTGFAYSTISGVSIGVNDFVIPEEKARIIDAATEEVKEIESQYASGLVTQGEKYNKVIDLWSKANDEVSKAMMANLSKEPVVDREGKTVEQESFNSMYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLSVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEIDCGTEQGLLMTPHIEGGDVVEPLGERVLGRVIAKDVFKPGTEDVIVPAGTLIDEKWVEFIELNSVDEVVVRSPITCETRYGICAKCYGRDLARGHQVNIGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRTSAADSVQVKNGGAIRLHNLKHVERVDGNLVAVSRSGELAVADEFGRERERYKLPYGAVISVKEGDKVDAGAIVAKWDPHTHPIVTEMKGIVTFVGMEEGITIKRQTDELTGLTNIEVLDPKDRPAAGKDIRPAIKMVDANGKELLLPGTDVPAQYFLPANALVGVADGAQIAVGDVIARIPQETSKTRDITGGLPRVADLFEARRPKEASILAEISGTISFGKETKGKRRLVITPTDGSDPYEELIPKWRHLNVFEGEQVNRGEVISDGPSDPHDILRLLGVSALAKYIVNEIQDVYRLQGVKINDKHIETILRQMLRKVEVTESGDSSFIKGDQMELTQVLGENERLAEEDKFVAKYTRVLLGITKASLSTESFISAASFQETTRVLTEAAVTGKRDYLRGLKENVVVGRLIPAGTGLAYHSERKRKRDADKPVRVSASEVEAALTEALNSSGN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RL30_PYRHO
Sequence: MAKLAVIRIRGRVNVKRPVRDTLAMLRLHRVNHCVIVDDTPSYLGMLQKAKDYITWGEINAETLAKLIRKRGKLIGNKPVTDEYVKEKLGMTIEEFAQKVINGEMSLKDLPNLKPVFRLHPPRGGFKGSKKRSFQEGGALGYRGEKINELIERML
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: TUSA_SHEHH
Sequence: MNDQFSAAQHQLDALGLRCPEPVMMVRKSVRRMNDGETLLIIADDPATTRDIPSFCEFMDHTLIASQTESTPYQYLIKKGL
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRP2_BOVIN
Sequence: MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNSSSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIENVPTYKWKRQVTQRNPVEQKKRKMSLLFDHLEPLELAAHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRAGVITHFVHVAEELLHLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLMVSLDQYQTEDELYQLSLQREPRSKSSPTSPTTCTPPPRPPVLEEWTSAAKPKLDQAIMVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISKEEMVSYFLRSSSMLGGRMGFVHNFHESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSMSLEGSAPSPSPTHTHHRAFSFSLPRPGRRGSRPPEIREEEVQTVEDGVFDIHL
What is the function of this protein?
Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP.  May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS.  Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation.  May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
What are the official names of this protein?
RAS guanyl-releasing protein 2, Calcium and DAG-regulated guanine nucleotide exchange factor I, CalDAG-GEFI.
What is the protein family that this protein belongs to?
Belongs to the RASGRP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Synapse, synaptosome. Cell projection, ruffle membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Enriched at juxtamembrane areas and membrane ruffles. Localizes to the cell bodies and axons of striatal neurons.
Protein: RL13_RIPO1
Sequence: MNKTITPNPETLDQKWYVIDAADQRLGRLASEVAQILRGKNKPTFTPHMDTGDFVIIVNAEKVVVTGKKSSQKLYRRHSGRPGGMKVETFEKLQARLPERIVEHAVKGMLPKNSLGRKLFTKLKVYTGPTHPHQAQQPETLIVNTIPTGEN
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PYRE_MALP2
Sequence: MSIENNIIKSLLEIKAIEVRKDKEKWFTWTSGIKSPIYCDNRLTISYPKVRNEIALSFKELIDTNFKDVQVIAGTATAGIPHAAWVSSLMNLPMVYVRNSSKQHGKTNQIEGLITKGSNVVIIEDLISTGKSSINVARCLREHGVNVLGIVAIFSYNLEIAKDAFMQENIKLFSLSNYDELINYMNEINQLNNNENQLLIDWRNGLNNK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: P5I11_PONAB
Sequence: MAAKQPPPLMKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFTIREPLGLRVWQFLSAVLFSGIAIMALAFPDQLYDAVFDGAQVTSKTPIRLYGGALLSISLIMWNALYTAEKVIIRWTLLTEACYFGVQFLVVTATLAETGLMSLGILLLLVSRLLFVVISIYYYYQVGRRPKKA
What are the official names of this protein?
Tumor protein p53-inducible protein 11, p53-induced gene 11 protein.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RUVB_BACLD
Sequence: MDERLVSSELDNHESAIEQSLRPQRLAQYIGQEKVKDNLKVFIEAAKMREETLDHVLLYGPPGLGKTTLAAIIANEMGVNLRTTSGPAIERPGDLAAILTALEPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATTRVGLLTAPLRDRFGVLSRLEYYTRDELSEIVIRTAELFEVDIDSLSALEIARRSRGTPRIANRLLRRVRDFAQVLGNSSITEEVAVDALERLQVDKLGLDHIDRKLLMGMIEKFGGGPVGIDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPDVYSHFKMEVPNHD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: GHRA_ECOHS
Sequence: MDIIFYHPTFDTQWWIEALRKAIPQARVRAWKSGDNDSADYALVWHPPVEMLAGRDLKAVFALGAGVDSILSKLQAHPEMLNPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHREDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESPLWQHPRVTITPHVAAITRPAEAVEYISRTIAQLEKGEKVCGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_SACS2
Sequence: MQITREKWSKNFSEWFDWVLREGEFYDYGRYPIKGMGVWMPYGFKLRQNIIGIIRNFLDSTGHEEVLFPLLIPEDLLRRESTHIKGFEEEVFWVTKGGSTDLDVKLALRPTSEVAITTMENLWLKSYKQLPKKYYQIVSVFRYETKATRPMIRLREITTFKEAHTVHETYDDAQKQVEEAIEIYKKIFDTLTIPYVLSERPEWDRFAGALHTYAFDTIMPDGRAMQIGTVHHLGQNFSKALDFKIQKKDGSLDYPHQTSYGISDRAVASVIAIHGDDHGPVLPPSVAPIKVVVIPIPAKNEEETQQVMKYSIEICEMFNKNNITCLTDQDTEKTPGEKFYIWEIKGVPIRLEIGPRELISGTVFIKRRDNFKSYTVRKEEAINKIKELLNEIQEDLRRKAWEDLKSRIEYSNDIEKAKKILGNNSGIVEVPWCGSNECGLKIEELTNARVLGYPIEKREVNDKCVICKMNAKTVLRIAKTY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPD_FUSNN
Sequence: MYSSNSEIKKKVTFILAAAGQGKRMNLNSPKQFLDYRGEPLFYSSLKLAFENKNINDIIIITNKENLNFMVKYCQNKNLFSKVKYIVEGGSERQYSIYNAIKKIKDTDIVIIQDAARPFLKDKYIEESLKILNDDCDGAIIGVKCKDTIKIIDENGIVLETPNRDNLIMVHTPQTFKFEILKKAHQMAEEKNILATDDASLVEMISGKIKIIYGDYDNIKITVQEDLKFLK
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.