Protein: TASS_HAPIR
Sequence: MTKIQEQEPIAVIGMACRFPGGSDTPSKLWELLQKPRDLSKRVPEDRFDSTGFFHENGTHHGATDCRDAYFLEEDVTRFDNAFFNIQPGEAEALDPQQRLLMETVYESLCTAGQTVEGLRGSRTAMYVGLMCDDWSQMTSRDWDLVPTYTATGTSRAVMSNRISYFFDWHGPSMTVDTACSSSLVAVHQGVTSLRNGEAPIAVAAGANLILAPGMWIAESNLHMLSPTGTSKMWDAAADGYARGEGIAAVVLKPLSAALRDGDNIDCIIRETGVNQDGRTAGLTMPSNTAQSQLIRDTYRRAGLDINDPKDRPQFFHAHGTGTPAGDPQEAEAISRAFFDKSDVKDPLYVGSIKTVIGQADIVGWWDSPPPPNRHTEGTAGLASLIGTTLAMKHGTIPQNLHFNTLSDRVAPFCAHLRVPAKSLPWPSPVTGQPRRASINSFDQWKKERTADSDFLPQIGFGGTNAHAIIEGYEPEQPPHLVTGPTTTKTSLFTPLTISATSSSSLRSMLSDLQKYLVNHPDTNLRDVAYTLQSRRSTFSYRRSVVCRSADDAVNRIEGLLVDTSAENGLNSRYADVSNPSSILGVFTGQGAQWPRMGAWLIEESPFVAQRLDELDEALATLPEGDRPDWKLSEQLLADASASRLSEAAIAQPLCTAVQVVLVDLTRAAGIHLRAVVGHSSGEIGAAYAAGFLSATDAIRVAYYRGVYAKLSRSPKDESIKGAMMAAGTSYEDALELCALEEFEGRLQVAARNSSSSVTLSGDEDAIDEVVEILKDEGRFARKLKVDTAYHSHHMQACAAPYLAALERANITAKDGNGTTWYSSVVDGQVMTKNIIQQSQYWVDNMTNAVLFAPAVTAAVAQAGPFDIAIEFGPHPALKGPCLDTVEEAAGSKIPYTGLLARQKNDVEELLAALGFLWTHLGAGSVNFDGFENAISGASSPRRLVSTLPAYPFDHSRSFYTLTRFSGGHQNMHSPLHPLLGRRCVETEADDEVSWRNILRSSENIWLQGHALQGQAVFPAMGYIAMAVEAAASLAGPDRRLGLISLEDVVIGRAMAFGDESVGMEAKVALKVSHFADDELRGKITCHSGLPHDSATPLALNFSATVNVTFHEPEAESLPAVRTDEINLANAEPQRLYSQFNKLGYNYSPPFTGVTSVHRKKGFATGTIEDISGDNWEDQLIVHPGLLDSALQTAFAAYCHPHDNRFWTLHVPTAIRSIVINPYFTDRGAGRHRQFEYQSSCRDGLESPVEADINVFAGQGQPHAFVQFESVRVQPFSVAGPQDDALIFSRFDYKLAEPDATVVVEGEGLPPPDADVIFQTIERVGFFYLRRIHETITPAEAAATLPHYKLLIEFTGRVVPRVAAGEHPTVPKEAMGDTTAYINSLLAKYRHRSDMQLIGIVGENIIPEIRRSGSMIEHMLQDGVLDRFYEEGFEYANIWIARVIAQIAHRHPRMDIFEVGAGTGGSTRAILPKLGDAFASYTFTDLSAGFFERANDRFINYADRMIYSTYNMENSPAEQGFEEGSYDVVLASNALHATGKLDETISNARRLLRPGGYLVLVEIMGNDFLGIGCSMGGLPGWWAGAAVDPTRSDGPCLNVNQWDALVRRHGFNGVETHTPLDRKLQWYAVLVCRAVDDRVVSLREPLSTTSPVPVSAADELVVVGGRTPAVASLVKESTELLKTRYTTITHIETLEEFNTTPLSQGSSVLSLTELDEQFLEVRTEAKLEALKTLWRNGRTISWVTRGARKENPHTSSMVGLARVMRYEYPHLNLQIVDYDRLPESKAIAESLLRLELGKTWESENLLWTVEPELHYVDGQLFIPRLYPYDEANKRWNTSRRTVTTEVDPHETTVVLEPSTDGNTVKPCAISPLRVRSDPPRRSSGKQITIRLQQSLLQSIKVGEAGFFTLCAGTDEESGESLVAFVDTPAESSVQVPVEWTVKTTEAADGSTALGYAATHLLAQSIIAAAVPRFGTLVVHEASSLLKDALDKEAAAEGIQVVFTTAEKTGKVDDGTVHIHQRLPARLVRKLLPRDVSVFVNLSPAPGASELLRSCLARHTATATVEDFVRIQPHISPNADIWEAGQALKTTWNAVTRHRRRTSNLEISKVISLNEANSVNPVEGPLTVVDWNTKSVEVALRPIDHGTIFRADGTYFLLGLSGELGQSLCSWMVSHGARNVVLSSRSPKVDPRYIEELAAQGANVRALACDITRRESLRACYDTIRAEMPPIIGVANGAMILEDVMFDDLEFESQERAMPPKVEGSLYLDELFYDTPLDFFVLLTSLAHIGGNTGQSTYVMANLFMVALAAQRRDIRGVVGSDMAIGSVTGMGFFERSALDKDHFSRMGYRNMSEQDLHTQFAEAILAGKPGAKGIPEVAIGLQPYRDTPNIQAQLRMDPRFKHYLLQDRGANTQGQAGGSQGNAKPRVRLASVTTRAEAIKVVFDTFVDRLKRILLMSATEVIDPMVSLVELGADSIMAVDVRGWFLKELDVDVPVLKILGPGETIALLVEEAVDKLPVDIVDISKLEHGGEPDLTQTAPAPKPEPVRQPELPPQPTSAASSSDTGSDSSPTSNSVSETQTGTPLETPMSTTEAGYFKQESQQLQQKLQKHQEQTSQSWRQKVVESSTEHTEQMTFGQNRFWFLTHYVDDPTTFNIAYVGKLTGRIRVDDLSKAVQAAAQRHESLRTRFFWSDDDTKTPMQGILSNTLVRLETATIKSAAEAAQELDEMRAYVWDLGDWVPLRMRLLSLSDTEHFLLIGTHHISMDGHSFSVLMLDIQQAYNSPGQRLAPLPVASQARAFGAHQRLSYETGKFKTAIEHHRSQLPAADLVRPIELFSFARTQVRPALDHYGTHVAKTHLPLATAAKLKQLARGHRATAFHAYLAGLQALLFRLLPAATTDKVFVGLADANRLDSKFMGSIGNFLNVLPVRFDRADRQTFGQAMEVARDRAYGGLKHSALPFDLLLDELEVPRSNAWAPVFQIFMDYRLVVKEHANKDWIGCKISEENWHTSRSGYDVALEIMEGHDGAMVAMHVQKALYDASAADLLLKTYVNVLNQVAAKGDKFVVKELATWDTESEQKGLATGHGPNLTLEWPATVAHRIDQVIADHPDAVALKDGHGRSLTYKEMDERVESIAHTLREHVPRTDKQPIVGVLQTPSADWMCSLLAILRFGGIYLPLDLRNGAPRLKSNVDAARPVAVLTDASSAGQVTDVCHHSDVVVINVSHLPASTGLPRMETTAATADGSAYIIFTSGSTGEPKGIVVKHSGLRANLEGYHREWAIDTMSDVVLQQTALSFDASLVQIFAALTTGGSLFVVPADARGDPSEVTKLMVENGVTMTQATPSEYDMWFRFAPETLHRCSTWKAAWFGGERAGPSVLDGFRKACRAIPSLRVFTSYGPTESTISAMKGEADVRNPDLRVPVPGRLLPNYAAYIVDDTLQPVPTGVPGEIVLGGAGVGANEYLNQKDMTDKQFPRDKFTSRGDSGWGRMYRTGDYGRLDARGYLTVEGRIAGDTQVKLRGFRIELAEIERVMVKEADGTISDAVVTLRGEGEQEGFLAAHVVFNGKIQGDKETGEAVDKLRARLPLCLPQYMCPAVIVPLDSLPLTSHHKVDRKALQTLELPKVEASVAEQLQNLTATERTLADLWDSLLPPRAAADALGPRSHFFSSGGNSLLLVKLQAAIKRDFGDAPRLSKLMSAPELGSMAALLDDGVGRVNWDKEIALDDELHGASWRARVTPAGADGISVLITGATGSLGRRITQRLANDNRVSRVVCLVRPVDGRDMANVFPGIGDKVQIMPADLPTLPADSDIPDIDVVLHCAADRNFWDGYHAVKPVNVDTAKALARLCLRRGATLHVLSSGAMAAYEGDDKTPGGSLPRPTPDDGYLSSKWVAERYLAGVARETGLPLTAHRPTRVSDAEALRVEQMGKTEMGMAKIMLSLSEKLNVRPDFTNLGGIIDLSPLEDAVEAVTQAVTTNIREEASGIRIINHAGTARMRTNALAAHAEELFGRAENSAVMGLPSVSALHWVGLAKRAGLFEWFFTAQDLVVEDGEGNTIASRR
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of the tetramic acids Sch210971 and Sch210972, potential anti-HIV fungal natural product that contain a decalin core (PubMed:25885659).  The PKS module of tasS together with the enoylreductase tasC catalyze the formation of the polyketide unit which is then conjugated to 4-hydroxyl-4-methyl glutamate (HMG) by the condensation domain of the tasS NRPS module (PubMed:25885659).  One unique structural feature of Sch210971 and Sch210972 is the tetramic acid motif proposed to be derived from the non-proteinogenic amino acid HMG, by a Dieckmann-type condensation catalyzed by the reductase domain of tasS (PubMed:25885659).  The aldolase tasA catalyzes the aldol condensation of 2 molecules of pyruvic acid to yield the intermediate 4-hydroxyl-4-methyl-2-oxoglutarate (HMOG), which can then be stereoselectively transaminated, may be by tasG, to form HMG (PubMed:25885659).  The Diels-Alderase tas3 then uses the Dieckmann product of tasS as substrate and catalyzes the Diels-Alder cycloaddition to form the decalin ring of Sch210971 and Sch210972 (PubMed:25885659).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase tasS, PKS-NRPS tasS, Tetramic acid Sch210971/2 biosynthesis cluster protein S.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.