Protein: TWMB_TALWO
Sequence: MAGEGAEIAIIGSGCRFPGNASSPSKLWALLQNPTSVASKVPALGGYYHEDALYHGHANVKEAYLLAGEETHRRFDAAFFGIKPSEANVLDPQVRLLLETVYEALEDGGQPMDSLRGSDTAVYAGQMVNDYELLMYRDLENLGRYHATGTSRTMVSNRVSFFFDWHGPSMTIDTACSSSLVALHNAVQQLQSGHSRVAIVAGANLIHDVGSFIAESSLQMLSPNGQSRMWDADADGYARGEGVAAIVLKTREAAEADGDHIECIIRGTAVNQDGKTPGQTMPSASAQAQLIRDCYARAGLDLTNSLHRPQYFEAHGTGTPAGDPIEAEAISSAFFPGASSSLSIFVGSIKTVVGHTEGTAGIAGLLKASLALQNKLIPPNLLFNTLNPRIKPFYDHLHVPTALTPWPSVASGYPRRASVNSFGFGGTNAHAILESYSPPSHPTQVLSTVYIPFVFSAFSEASLKSYLVAFSTYLRENKTTYDLRDIAYSLDARRTRHQVVTTISASTADELCDSIEKKLELSRADPDQRVGVRATHQTAEARKPRVLGVFTGQGAQWAQMGLELITASAVAKSTVESLQKRLDRLPDADRPTWSLVQELERDSSSSHIMEAKFSQPLCTAIQILQINLLRAAGIEFTAVVGHSSGEIAAAYAAGRISAEDAICIAYYRGLYSSLAYGLNGKPGAMMAVGTSPEDAEDLLGFPEFEGRACVAAVNSATSVTISGDQDALEELKVVFEDEHKQARFLKVDKAYHSHHMKECSAKYLESLAALNIQVGSGSQTSWFSSVYEQEVKGRDFLKGPYWDDNMVEPVLFMQAVDNACASTRHFDLAIELGPHPALKGPALQTIQERLSHQIPYTGLFTRGVPAITAFSEGLGYCWTHLGQGVVNLQNYDNFISGNLKCRLVKGLPTYAWDHENEYWHETRYARAVRMRPGPVHDLLGHLTPNSTDQDMRWRQFLRLPEVKWVTGHRLQNLTVFPAAGYIVSVIEAAMSLCKDVSVTLIEIIDVDIDSALVFDNDDVSIEVIISLTGITRRENKAIEADFKYHATSGKDTEPLKLKASGRVRIHLGEACPTVLPPRAQKPPNLVSVSEKKFYDSISELGYQYSGQFASLERIERKLGAATGFISITEASKYLIHPGALDAAFQSTHLTYAAPEDGESRSIYIPRRIKRLTFNPNLCIHARNKQTDLAFDASQPIELPHANKLCDINLYPEHLDHAIIRVQGLECVPFSRQTAKDDREAFSNIVWDVLDPDVEAITKDYHSKTSDSLELAGLLERVAAFYLRSLEKEVPENHPSRYEAPCKGLLQYASNISSQSCATRSQLTQAHWDHDTSEVLTAVCEPYADSIDMKLVFDCGKNLASSVMGESTAGEVSGLMQEWYRSGSGVKNFTAHLAGILKQIVHRYPQMHILEVGPEAGAATNVILTEIGPAFASYTVATSTDILFNPEKALPDIYKAKVLPKELDLSKNPRDQGFTEKSFDVVVASLVLHQSPEFEKCLRNARRLLKPGGHLIVLELRPSLPYFLSVIFSAKSHQWFNAEEGRTSFPAITLLEWDSLLRQTGFSGIDTSTVEQPEIGGPFSIFVSQAMDEKIAFLREPLSTAFPISSPGPTIQDLLILGGNSLKTARLVNQLSAVLKEHCGSLRTARSMGFVDDISPKTIILSLTDLDTNEFKQLDESKWDSLKKIVSHTGTLVWVTHGRLADNPHANMMLGLLRGSARDNSTLDYLLLDIEEAHRIEHSVIAEAILRHRAASQWRESESISYSVESELVMDKAGRFLIPRLMMNEKMNDRYNSNWREIREPARPSLDNIAISASGSGWDVVLEPLPPVRRAQLRTTHSLLSPIRVTGSGCMYISLCSGLLSGDKVIALSSKNNSVVCPQDELSVPVEVPPGSEARFLWLTAHYLLASSILKGLSEEDQVLIHEPSLEFSTAIENEASMLGVEVTFTTKNQDAPDSWMVIHPFSFEQSALARFEDEIFSVFINMAPSQEETESVADIFATALPGHCRKESLRSLFGNKAWTPKGSQIKEIQRRLLRAVSWASGMLTKSHCDGMTSLAIDVLPGTVGQLEPFAVIEWDTVSEVSVKVQPVDTLVSFSDKKTYWLVGLTGGLGLSLCEWMVRRGARYFVISSRQPNIERGWLDGMHKKGVRVEISACDLSKRDQVEGLYAEICSSMPAIGGVAQGAMVLEDVAIQNMTLEQLSRVTKPKVDGSIYLNELFQENTLDFFVFFSSVSSVVGNHGQANYAAANTFMASLAEQRRRKGLAASVMDIGAVFGVGYITRSGNEKLMGKVTLQSGGYVRTSERDFHQLFGEAVLAGKPGSTGPIELVSGVRKVSQREEERPVWETWPRMSHFVMDHEGPEYTTDASNKAHIPVKVRLAEARNNEEAYGIVWEDFVRKLQSLFQIDITSLTKAELGAMRLDQMGIDSLTAVEIRGWLMKTFEVNLPVLKILNGISVGELVDTATEAIPSHLVPNLAGYPAEQTSSQNSDSGQDMASSFDTVVNNPFDSDQVSSFHSDLSSNQEDATATDSKSTVLKSIPVSFTQARFYPSGLFLEDKVGLNHIAWARFTGEVSAERLQRALHSLAEQHEILRTAFFDQAGKQMQHILNTSPVYLEHKQIQNEDEVTELVMSLQKEYVYDVARGETMRVILLSRSATENYFILGVHPLVLDATSFQIYLKWLAFHYTSPNKIHRVKQFAESSEQRHADYAAGKFEAELQFWRNEFSTPIKPLPLLTVAKVNERPKLKAYENIRSSLTIEVDTKTRILDICRRIRATPFHFYLAVLRVLLLQYTAYGDNSEDVTIAVAENGRGYDAEEMDVIGPLYNLVLVRILAQQTTRFEDLLETTRNKTYAALSNSKLPYPMLVEELGLQRIAKDYPFVQVFADYRVGQRTTAEFGEDNKLVMMGFDFNVPYDVFLDTIDEPEGECLHELFLRNDLFGREEADRLARSYKSLVVAFAEHPAMTLGQAALAESECGGKIAQ
What is the function of this protein?
Polyketide synthase-nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of wortmanamides A and B, reduced long-chain polyketides amidated with a specific omega-amino acid, 5-aminopentanoic acid (5PA) (PubMed:29343058).  The PKS modules of TwmB are involved in the synthesis of the polyketide backbone, whereas the non-canonical C domain of TwmB is a bonafide condensation domain that specifically selects 5PA and catalyzes amidation to release polyketide chain (PubMed:29343058).  The C domain clearly prefers C16 and C18 fatty acyl substrates, which is consistent with simultaneous formation of both octaketide and nonaketide acyl amides wortmanamides A and B (PubMed:29343058).  Because TwmB lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase TwmE (PubMed:29343058).  The roles of the remaining enzymes have still to be clarified (Probable).
What are the official names of this protein?
Polyketide synthase-nonribosomal peptide synthetase TwmB, PKS-NRPS TwmB, Wortmanamides biosynthesis cluster protein B.