PharMolix/UniProtQA huggingface dataset:
Protein: KHDR2_RAT
Sequence: MGEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGRKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEESGRGRGIRGRGIRITPTAPSRGRGGAVPPPPPPGRGVLTPRGTTVTRGALPVPPVARGVPTPRARGTAAVPGYRAPPPPAPEAYEEYGYDDGYGGEYDDQTYEAYDNSYVTPTQSVPEYYDYGHGVNEDAYDSYAPEEWTTTRSSLKAPPPRSARGGYREHPYGRY
What is the function of this protein?
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion.  Its phosphorylation by FYN inhibits its ability to regulate splice site selection.  Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer.  May function as an adapter protein for Src kinases during mitosis (By similarity).  Binds both poly(A) and poly(U) homopolymers (By similarity).  Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity).
What are the official names of this protein?
KH domain-containing, RNA-binding, signal transduction-associated protein 2, Sam68-like mammalian protein 1, SLM-1, rSLM-1.
What is the protein family that this protein belongs to?
Belongs to the KHDRBS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPXA_CHLT2
Sequence: MTNIHPTAIVEDGARIGNNVTIEPYAIVKKSVTLCDDVVVKSYAYIDGFTTIGRGTTVWPSAMIGNKPQDLKFKGEKTFVEIGEHCEIREFAMITSSTFEGTTVSIGNNCLIMPWAHIAHNCSVGNNVVFSTHVQLAGHVQVGDCVTIGSMVGVHQFVRIGSYSMVGAMSGIRRDIPPFTIGTGNPYALGGINKVGLQRRQVSFETRLALIKTFKRVFRSDESFQASLESVLEDFGEVPEVRHFVEFCRQPSKRGIERGVDCEASLEEPIDKKEGAFVES
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOOK_CAEEL
Sequence: MLDLTNKESESSDNGNSKYEDSIDGREVGTSKPFKEERSLEDLQADLADMAVWMEGLDATKLPLNDPQLLCNGRAFSEVLHNVDKNFFTDGWLETMPENRTTNIMVFRSCTRKLWRKMFDYVNHINRTVVSSRWTDIHERIDGIYESDLPAMVNLGMAVVTLAHIGKNAKRFVDYSKALTSTHKSMMSNVAKMVTTVIDEMPENPCFHEISELHGSQSELNSLSESSGKLNGNGSSERRSNADQILVDAELEIERLRTETENQRKEIERLTKSFETAQHDMSSNSESGDISILEKQNEELRQKRRELEEKNLELDAAVDQFKGIVFELTNENDVLRRSDKERQRLQTVLDAAQSDLDEWKTVANQYQKEAELSKQQDKEIKELLSQNKALKSRLDHHVKSATLEDANKNGIAQLRTQVGGLTALNTELKASLDSKKRCVEQLEIQLIQHKEKVKELEDRKDELIEERNRLENQLIFKEAVTPRSLHESMFEAGNLSFEPFSEKNTLPLEIENKRLTERIQELESLEPLKGELITLKSKNGVLEEEKLFATKQIEELQQQIEDLQENLLKNQEHASGDVVGLKIQLEKAEVEAQQMREAKMRAETNQAQVDEILKKRTAELEVNATALQKAKAVIDELEYNSRPVSEDSMTSVQAFKEMKEENEKLRQKVEKLEIELNTVTQGFEQENRLLTSASHQQVLNRSIDEVMSMRAHAGSEEPQTLLDTQKMSGALPWRSLASETRRELPTAMASILVLGFLVFIAWMFININSALNAPPNA
What is the function of this protein?
Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus (PubMed:14697201).  Required for dynein localization to the nuclear envelope (PubMed:14697201).  Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair (PubMed:27956467).
What are the official names of this protein?
Zygote defective protein 12.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Nucleus membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Note=Localizes to the minus end of microtubules, proximal to the centrosome. Centrosomal localization requires sun-1 and microtubules.
Protein: RL21_METBU
Sequence: MPTSHGERSCTRYKLKKTVRERGLSPISKAIQDFEEGQMVHIDIDPSVQKGMPNAKFQGKTGKVLGKRGRAYLLQVTDGNSKKEVISLSQHLKPQKY
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: COAA_BRUME
Sequence: MWEKVDQLTPSRYSPYRFFSAQEWAAFRADTPLTLTYEEVKRLRSLGDPIDLDEVRRIYLSLSRLLYAHVEASQLLFRQRQQFLNMEESYKTPFIIGVAGSVAVGKSTMARILKELLARWPSSPKVDLVTTDGFLYPNAVLREQNMMERKGFPESYDIGAVLRFLSAIKAGMSRVRAPLYSHLSYDVLPGEYQIVDKPDILIFEGINVLQVRDLPEDGKMVPFVSDFFDFSIYIDADPRLIHKWYIDRFMRLRETAFRDPQSFFHRYSQLSQEAARSIAEGLWQNINLKNLNENILPTRPRADLILRKGSDHLIEEVALRKI
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_FRATN
Sequence: MITTRFAPSPTGFLHVGGVRTALFSWLYAKNNNGKFILRIEDTDLERSTQEAVDAILDGMSWLGLKNDGEIYYQTKRFDRYKEVIQELIADGKAYYCSCSKERLEELREYQQANNLKTGYDGKCRDANYVPQQGESYVVRFKNPQDGVVSWDDAVKGRISISNHELDDMIIQRADGSPTYNFCVVVDDIDMAITHIIRGDDHVNNTPKQINIYKALNANVPVFAHVPMILGPDGAKLSKRHGAVNVMQYREDGYLPQAILNYLVRLGWSHGDQEIFSIEEMIKAFNLEHINASPSRFDFEKLKWLNKHYIKESKFDDIQTEVEYHFAKTGLDISNGPDLKELVAVMAEKVDTLVELAEKSSYFYSDDISYDENAVKKHIKASTGEIFVKLLENFEALDAQQWQDPDVLHNIVSTTAEQCQVGMGKVGMPLRVAITGSGQSPDIGITLKLLGKNKVVARLTKALEELCK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNJE_ECOLI
Sequence: MKRVSQMTALAMALGLACASSWAAELAKPLTLDQLQQQNGKAIDTRPSAFYNGWPQTLNGPSGHELAALNLSASWLDKMSTEQLNAWIKQHNLKTDAPVALYGNDKDVDAVKTRLQKAGLTHISILSDALSEPSRLQKLPHFEQLVYPQWLHDLQQGKEVTAKPAGDWKVIEAAWGAPKLYLISHIPGADYIDTNEVESEPLWNKVSDEQLKAMLAKHGIRHDTTVILYGRDVYAAARVAQIMLYAGVKDVRLLDGGWQTWSDAGLPVERGTPPKVKAEPDFGVKIPAQPQLMLDMEQARGLLHRQDASLVSIRSWPEFIGTTSGYSYIKPKGEIAGARWGHAGSDSTHMEDFHNPDGTMRSADDITAMWKAWNIKPEQQVSFYCGTGWRASETFMYARAMGWKNVSVYDGGWYEWSSDPKNPVATGERGPDSSK
What are the official names of this protein?
Thiosulfate sulfurtransferase YnjE.
What are the subcellular locations of this protein?
Periplasm.
Protein: PETL_SACOF
Sequence: MLTITSYFGFLLAALTITPALFIGLNKIRLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RL34_ACIAC
Sequence: MKRTYQPSKTRRARTHGFLVRMKTRGGRAVINARRAKGRKRLAV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: Y766_BACMK
Sequence: MNIWLNMLITTGLGAIIGGYTNHLAIKMLFRPHRPIYIGKFQVPFTPGLIPKRRDELAVQLGKMVVDHLLTPEGIGKKLTNKEFQTSLIRWTQVEVDKVITNEQSLRDMLEKWNLEHVEEEAIGKIEHVITEKIHAFLAEYYTYTWEQALPHSVHEKVENAIPNVASFILKRGISFLESEEGKERLSKMIDDFFASRGTLLNLVGMFLGNVSLVDRVQPEVIKFLGQDGTERLLTDVLQKEWEKLKGRDVKELETFVEKEMIVNSILSAVKVEETVSRFLNQSVQQVCEPVRETIVGKVVPSAVEKGLKWGTENVGSILGNLQLAEIVQQEVSTFSTERLEDLVLSITKNELKMITYLGALLGGTIGFIQGLLLLFLK
What are the official names of this protein?
UPF0754 membrane protein BcerKBAB4_0766.
What is the protein family that this protein belongs to?
Belongs to the UPF0754 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS19_RICAH
Sequence: MARSIWKGPFVDGYLIKKVQKLMESGKSEMIKTWSRRSTILPIFVGFTFSVHNGNKFVPVSVNEEMVGKKLGDFAPTRTFYGHGADKKVKRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SYT_SALPC
Sequence: MPVITLPDGSQRHYDHPVSPMDVALDIGPGLAKATIAGRVNGELVDACDLIENDATLAIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVVDNGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHDARETFVKRGETYKVAILDENIAHDDKPGLYHHEEYVDMCRGPHVPNMRFCHHFKLMKTAGAYWRGDSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGALHGLMRVRGFTQDDAHIFCTEEQIRDEVNACIRMVYDMYSPFGFEKIVVKLSTRPDKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVVMNITDSQSGYVNELTQKLQNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVEAGKVAVRTRRGKDLGSLDVNDVIEKLQQEIRSRSLQQLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXJ_WOLPM
Sequence: MKLGVNIDHVATLRNARGTSYPDPLKAAEIAIDAGADFITVHLREDRRHIRDEDVFNLKKSISTELNLEIAATEEMLEIAKKVKPYSISIVPEKREELTTEGGLDIVNMHSKLSSIIEEMHSSSIKVSLFIDPNIDQLKYLEKLGTKPDIIEIHTGDYCDNPSEKKLQLITNAAEYVNKLGIECHAGHGITYKHAKKMTRIPHISALNIGHYLISEAVFYGLHSVVKTMKMTMSN
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_CAVAP
Sequence: MAYPYELGFQDASSPIMEELLHFHDHTLMIVFLISTLVLYLITIMLTTKLTHTSTMDAQEIETIWTILPAIILILIALPSLRILYMMDEINSPSLTVKTMGHQWYWSYEYTDYEELSFDSYMVPTMDLKPGELRLLEVDNRVVLPMEMPVRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATLMSSRPGLYYGQCSEICGSNHSFMPIVLEMVPLKDFEIWSSSML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GLGA_SHIDS
Sequence: MQVLHVCSEMFPLLKTGGLADVIGALPAAQIADGVDARVLLPAFPDIRRGVTDAQVVSRRDTFAGHITLLFGHYNGVGIYLIDAPHLYDRPGSPYHDTNLFAYTDNVLRFALLGWVGAEMASGLDPFWRPDVVHAHDWHAGLAPAYLAARGRPAKSVFTVHNLAYQGMFYAHHMNDIQLPWSFFNIHGLEFNGQISFLKAGLYYADHITAVSPTYAREITEPQFAYGMEGLLQQRHREGRLSGVLNGVDEKIWSPETDLLLASRYTRDTLEDKAKNKRQLQIAMGLKVDDKVPLFAVVSRLTSQKGLDLVLEALPGLLEQGGQLALLGAGDPVLQEGFLAAAAEYPGQVGVQIGYHEAFSHRIMGGADVILVPSRFEPCGLTQLYGLKYGTLPLVRRTGGLADTVSDCSLENLADGVASGFVFEDSNAWSLLRAIRRAFVLWSRPSLWRFVQRQAMAMDFSWQVAAKSYRELYYRLK
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: FLBT_BRUAB
Sequence: MAANSKTAIRLSLRAGERIFINGAVLRADRKVSLELLNDATFLLENHVLQPEDTTTPLRQLYFAAQMMLIEPAMREQAGATFAQMLKGMFAMFKDAEILNALKLVDELVHNGRVFEALKTIRAQYPREAELMGAQPVVWPVTKSGKSAGANP
What is the function of this protein?
Has a post-transcriptional repressor function in flagellum biogenesis.  Associates with the 5'-UTR of fljK mRNA and promotes its degradation.
What are the official names of this protein?
Probable flagellum biosynthesis repressor protein FlbT.
What is the protein family that this protein belongs to?
Belongs to the FlbT family.
Protein: BXL3_ARATH
Sequence: MASRNRALFSVSTLFLCFIVCISEQSNNQSSPVFACDVTGNPSLAGLRFCNAGLSIKARVTDLVGRLTLEEKIGFLTSKAIGVSRLGIPSYKWWSEALHGVSNVGGGSRFTGQVPGATSFPQVILTAASFNVSLFQAIGKVVSTEARAMYNVGSAGLTFWSPNVNIFRDPRWGRGQETPGEDPTLSSKYAVAYVKGLQETDGGDPNRLKVAACCKHYTAYDIDNWRNVNRLTFNAVVNQQDLADTFQPPFKSCVVDGHVASVMCSYNQVNGKPTCADPDLLSGVIRGQWQLNGYIVSDCDSVDVLFRKQHYAKTPEEAVAKSLLAGLDLNCDHFNGQHAMGAVKAGLVNETAIDKAISNNFATLMRLGFFDGDPKKQLYGGLGPKDVCTADNQELARDGARQGIVLLKNSAGSLPLSPSAIKTLAVIGPNANATETMIGNYHGVPCKYTTPLQGLAETVSSTYQLGCNVACVDADIGSAVDLAASADAVVLVVGADQSIEREGHDRVDLYLPGKQQELVTRVAMAARGPVVLVIMSGGGFDITFAKNDKKITSIMWVGYPGEAGGLAIADVIFGRHNPSGNLPMTWYPQSYVEKVPMSNMNMRPDKSKGYPGRSYRFYTGETVYAFADALTYTKFDHQLIKAPRLVSLSLDENHPCRSSECQSLDAIGPHCENAVEGGSDFEVHLNVKNTGDRAGSHTVFLFTTSPQVHGSPIKQLLGFEKIRLGKSEEAVVRFNVNVCKDLSVVDETGKRKIALGHHLLHVGSLKHSLNISV
What is the function of this protein?
Involved in the hydrolysis of arabinan.  Can hydrolyze (1,3)-alpha-, (1,2)-alpha-linked side group residues and non-reducing terminal L-arabinofuranose residues of debranched (1,5)-alpha-L-arabinan backbone.  Acts also as a beta-D-xylosidase, releasing D-xylose from arabinoxylan and xylan.
What are the official names of this protein?
Beta-D-xylosidase 3, AtBXL3, Alpha-L-arabinofuranosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: METK_SALAR
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILQQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHAEDIDQKSLQEAVMEEIIKPILPSEWLNTSTKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVSSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGRENFPWEKTDKAQLLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIDH_ASPFU
Sequence: MSTEAHPTVQGCLVSFPTPHILLLTLNRPEKRNCISLATSAEIQRLWTWFDTQPALYVAIITGTGESFCAGADLKEWNDLNARGITNEMTAPGLAGLPRRRGSKPIIAAVNGYCLGGGFEMVANCDIVVASENATFGLPEVQRGIAAVAGSLPRLVRVLGKQRAAEIALSGLSFSASQLERWGLVNRVVEHDQLLATAVEIATAISRNSPDSVRVTMEGLHYGWEMASVEEASSALVDQWYAKLMAGENFHEGVRAFVEKRKPQWRPSKL
What is the function of this protein?
Mevalonyl-coenzyme A hydratase; part of the siderophore biosynthetic pathway (PubMed:22106303).  Aspergillus fumigatus produces 4 types of siderophores, low-molecular-mass iron chelators, including excreted fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake and intacellular ferricrocin (FC) for hyphal and hydroxyferricrocin (HFC) for conidial iron distribution and storage.  TAFC consists of 3 N(2)-acetyl-N(5)-anhydromevalonyl-N(5)-hydroxyornithine residues cyclically linked by ester bonds; FC is a cyclic hexapeptide with the structure Gly-Ser-Gly-(N(5)-acetyl-N(5)-hydroxyornithine)x3.  The biosynthesis of all four siderophores depends on the hydroxylation of ornithine, catalyzed by the monooxygenase sidA (PubMed:15504822, PubMed:16113265).  Subsequently, the pathways for biosynthesis of extra- and intracellular siderophores split (PubMed:17845073).  For biosynthesis of extracellular siderophores, the transacylase sidF transfers anhydromevalonyl to N(5)-hydroxyornithine (PubMed:17845073).  The required anhydromevalonyl-CoA moiety is derived from mevalonate by CoA ligation and dehydration catalyzed by sidI and sidH respectively (PubMed:22106303).  The acetylation of N(5)-hydroxyornithine for FC biosynthesis involves the constitutively expressed sidL (PubMed:21622789).  FC is hydroxylated to HFC by an as yet uncharacterized enzyme during conidiation (PubMed:17845073).  Assembly of fusarinine C (FsC) and FC is catalyzed by two different nonribosomal peptide synthetases (NRPS), sidD and sidC respectively (PubMed:17845073).  Subsequently, sidG catalyzes N2-acetylation of FsC for forming TAFC (PubMed:17845073).  Both extra- and intracellular siderophores are crucial for growth during iron limitation and virulence (PubMed:16113265).
What are the official names of this protein?
Mevalonyl-coenzyme A hydratase sidH, Siderophore biosynthesis protein H.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Peroxisome. Note=Targeted to peroxisomes via its PTS1-type peroxisomal targeting signal and the corresponding receptor pexE (PubMed:23617799).
Protein: ZMAT5_BOVIN
Sequence: MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKLWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSVQVEEERRAREWPLDVAELPEVCLEDWLEKRAKRLSSAPSSRAEPVRATVFQYPVGWPPVQELPPSLRAPPPGGWPLQPSVQWG
What are the official names of this protein?
Zinc finger matrin-type protein 5, U11/U12 small nuclear ribonucleoprotein 20 kDa protein, U11/U12 snRNP 20 kDa protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPXB_HELPH
Sequence: MPTILVSALEASSNIHLEELRQNLPKDYRFIGVFEGKNALYSPREFSIMGFRDVIGRLGFLLKAHKEMVQLAKQADMVLLMDSSSFNIPLAKKIKKQDPHKKIMYYILPQVWAWKKWRAKSLEKYCDFLGAILPFEVGYYQKKAQYVGHPLLDEIKYYKKDIKGETLVFMPGSRKSEIAKIFPLFVKAAQILEQNEGFKRRVLVVPSFFKGLDLKALYGEDIELFEISYDAHKSLFEAEFAFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMLVNLHYIGLANIFYNALNDETPGLGESQLHPELIQHFLSVEGLLKAYEEMDRERYFKESLRLREYLASGSARKIANEMAFLLNLT
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: HIS5_COLP3
Sequence: MTSAKNVIVDTGCANLSSVKFAVERLGFEVTITDDITIIQQAEKVIFPGVGSAKHAMKNIKAKNLEAALQGLTQPVLGFCLGMQLMTESSTEGKKSSTEGNNDDNTSHIVPCLNLIPTNVEPLKAQGNRLPHMGWNTLTQVSNHPIFKGISEGDYFYFVHSFAAPISEYTIASCEYGSTFSAAIAKDNFIGCQFHPERSSALGSKIIQNFLELDSTELNQELVNL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFR3_DEBHA
Sequence: MPIFRPKHQKLILQCYPPGKGVDKKPNPSELSYLLYYASTRRVKLEKVVTFLDRKTTSDAKHNRAGNLQVTLTIISSLIEECSENLNVFASFVCSILKSVLQSKDLSLCKHAIQTYGVLCSKLDGGLFSGDKVFVDSFGSLSQNLINIGSENSKKRGPNNLEWQMISLMTCRYISNCLGYNSKFSKKFIEICIPILTETVHANNKQSNLLTILKSNVNIEDENHHLGRIASTKTNQTSRKAQQDLDNDAVKDSDLNEEALRGLKALFSTSLTSQISEATRAIVKNNYATTIDPIWGCTFLEMCTTWIPVQLRFITLSTVLSSLTSLSNKSTKKTSNYPIQLLYANYCLGLVSSDVNMIGLSISDVIQQILFLQANLLLSQSHYFQEEDVKKLSMIYSNCICNLSTHIYYFDQVPDSIREILIKVVSILENSVISGNANSSGVYRFIITLLEDISIIFDLLQTKPSNISRNHVSLEDWDLSLILLSSEIGLNPTKDQKPLFSYEQITDIQFKYLRVFGYFLNNELVTRNENMETGAINSIESFNVGGDHLQPDYNNYISDPGNFIAHFLGYVDKFFSGQSLINIDNASLLQKVLKNMILILGINFINNFVPFFFYWQLPLNPNLVDDNTRIKDTLGYTLIYHSLIKMDKIYELNYVRESEFFNSLLGDINYRKLNKLWVNGLQSKEEDAVLDNHHALGHRDENGTLRFNPTKKNLEDFVIGNAFTLSWINPHRPLILDIVNNYIPKKENNQNVLSDMSDESSIIENSSYHTSARQNGFGLGLGNANDISSIHSGLLFHQSQNVNMKNAFSNGNETSNGSIYTSDRQYNTPRVSDLKDSVLMKKKPGVAFNEHYNSDTTPGSILSKQMVTSDIDSILEGLDIDDDSEIIV
What are the official names of this protein?
Protein EFR3.
What is the protein family that this protein belongs to?
Belongs to the EFR3 family.
Protein: MINC_YERPB
Sequence: MSQSPIELKGSSFTLSVVHLHDSRPEVIRQALQEKVDQAPAFLKNAPVVINVATLPNGANWKDLQQAVTSAGLRIVGISGCQDERQKRAIARAGLPLLSEGKGQKLAPEPVISPPENVPTQTRIINTPVRSGQQIYARNCDLIVISSVSAGAELIADGNIHIYGMMRGRALAGASGDAKCQIFCTHLGAELVSIAGQYWLSDQIPLEYFGQAARLYLQDNTLTIQPLN
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: SNM1_ARATH
Sequence: MDFSDEDDDENCFGSRFNDGVNEEEEDEEGFVFNDDVEENEEEEGFASDFYKAGSDWSCLVEDEETVSSSVKKMKQSNLFQIWGLQENSPDTTKKMKQTDLFQSWGLQKPSPFTSPASNSAKKTTSALGKRRRDSSFSNDSPRPCPFYKKLPGTPFTVDAFRYGCVQGCSAYFLTHFHADHYIGLTKAWSHGPIYCSSLTSRLLRLSLSVNPSSIHPLELDVEYTINGIKVTLIEANHCPGAALIHFRLLDGTCYLHTGDFRASKQMQTHPLLFNQRVHVLYLDTTYCNPRYKFPSKEDVLSYVVRITKDFLRKQPKTLIVVGSYSIGKECVYLAIAKALGVKIFANASRRRILQSFGWDDISKNLSTDGKATCLHVLPMSSLKVERLDEHLKIYREQYGAVLAFRPTGWTYSEKIGEHLDLIKPTSRGKITIYGVPYSEHSSFTELREFVQFLRPDKIIPTVNNGNAGTREKMQSCFREWLRR
What is the function of this protein?
May be required for repair of DNA lesions formed after exposure to oxidative stress.
What are the official names of this protein?
DNA cross-link repair protein SNM1, AtSNM1.
What is the protein family that this protein belongs to?
Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLGA_BORBR
Sequence: MTTIRTLVVAAEAFPLAKTGGLGDAVAGMVQALGHRPGGVDVQCELLMPAYRGTLDRLYRPRTVARLGGLPGGPASLVRGHCPGSGLSVLLLRNDALYDRPGIYVDDSGQGYPDNARRYAALAHAAARLAQGLPGLRPPHVVHAHDWHAALAPLLIHAAGLHYVKTLLTIHNLAFQGTFPAELASALGIPLACRHDDGALSDDRVNFLKAGIRYATRVTTVSRAYAREILTPAFGCGLHGLLRARGADLSPVPNGIDTALWNPAADPHLGGLRFDALDMRNKACCKAALQAELGLQLRADATVLAMGSRLTGQKMADVAIAALPALLEAHEHLQFALIGRGEPDLEAALRALAARYPGRCAVHIGYDEPLAHRLHAGADLLLHGSRFEPFGLTPLYAMRYGTLPVASRVGGMVDTIRDPGPAIEESCAGQGTGFLFDGSEPADMRQAVTRALRALAKPAVRDAMRRNAMQADFSWRTSAQAYAGLYANLASGPQRGRVPAPTLPLLANAA
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.