PharMolix/UniProtQA huggingface dataset:
Protein: SUB1_ARTGP
Sequence: MGVFRFISISLAAVSAANAAQILSMPHAQTVPNSYIVMMKDDTSDDDFNHHQSWLQSTHTHNITRRATVQNAGMRHKYNFHKMKGYSGVFDDETIKDIAKDPKVMFVEPDTIISVHGKVDQNNVPSWGLARISSSKPGTQDYTYDSSAGEGITVYSVDTGVDINHEDFEGRAIWGSNQVNDGDDNDRSGHGTHTSGTMVGKEFGIAKKAKLVAVKVLGNDGSGPTSGIVAGINWCVEHARQNGGTNKAVMNMSLGGGSSSALNRAAAQAVEQGMFLSVAAGNDNTDARSSSPASEPSVCTVGASAEDDSRSSFSNWGPSLDLFAPGSNIISARPGGGSQSMSGTSMAAPHVAGLAAYLMALEGISGGAVCDRLKQLGSASISDVGPGTPTNVLINNGGAKGDGKSPKPSPKPSHPSEPQQPTEPQQPAPGEPSTPAPAPMPPTPQHPHTPFPGGDDFDFDGFWKKYFGGEHWRKMFSSFFN
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CASA1_NOTEU
Sequence: MKLLIFSCLVTLALARPDALRLSIDRHFKHRELENRLNEDPIPVSEASSSEESVHQLNRDRRPLEKYELDKYREDLKTSSSEEFVTPSTNERVRRQVEYNFNEEDSSASRERKIEDFSEHDRQYLRRRVEERALNLRYLEPLYYATEPEYYYYYAYVPVSSHDIPYQQKPLSLLPAKSHYLISTGLLNEPLPILRERLGRGFQSPSLLILVLTENSNLFMGSVFYWCLQIAHPMQEI
What is the function of this protein?
Important role in the capacity of milk to transport calcium phosphate.
What are the official names of this protein?
Alpha-S1-casein, Alpha-casein.
What is the protein family that this protein belongs to?
Belongs to the alpha-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS11_TREPA
Sequence: MAVTKKRKEKKNVYEGNVYIQATFNNTIITVTDLQGNALSWASSGGLGFNGAKKSTPFAAQTVAEAAVQKAQQCGLREVHVFVKGPGIGRESAIRMLGTMGLRVRSIRDITPIPHNGCRPRKTRRI
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RPSC_MYCBO
Sequence: MTATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYLSDVGSADDLTQETFLRAIGAIPRFSARSSARTWLLAIARHVVADHIRHVRSRPRTTRGARPEHLIDGDRHARGFEDLVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPVGTIRSRVARARDALLADAEPDDLTG
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
What are the official names of this protein?
Probable RNA polymerase sigma-C factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. ECF subfamily.
Protein: HBA_TARGR
Sequence: MKLSAEDKHNVKTTWDHIKGHEEALGAEALFRMFTSLPATRTYFPAKDLSEGSSFLHSHGKKVMGALSNAVAHIDDIDAALCKLSDKHAQDLMVDPANFPKLAHNILVVMGIHLKAHLTYPVHCSVDKFLDVVGHVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RECG_TREPA
Sequence: MLIGEIKEPVSVLKGTGKVVLAQLERLNISTIGDILSYWPRLWEDRTQEQMFSQWTLAHRLQVRVSVTAHCWFGFGKSKTLKLVVQDGQGCVAELLCFRRNFLHFMFPVGSEAVVYGSFYEKDGLLESSSFDIEKIDCIEKKILPVYPLTKGLKQMKLRMLICAAMDQWIGTVDSELPKPILEKYHLLTKRDVLLSMHTPRTLDDVAKGKHSLIFEEFFSLQMTIGMRSLQKRGRLPLTQGESDQQSAIPSVVSELSLLQKKLHRCLPFELTVDQKRVITEITQDLEREEPMARLIQGDVGSGKTLVAFFSCLKIIEQGGQVALLAPTELLARQHADTAARLLAPIGIRLAFLTGNVKSEGRAYLLEALVAGEINLVVGTHALFSKSVRYHDLRLVIIDEQHRFGVLQRSALIQKGREGNPQGKTPHIIMMSATPIPRTLALSVFGDLDISIIKSMPGGRKPVITYIARKTKAEKVYEFVGNEIEKGRQAYFIYPRIHDIGLTDLKSVQCMYMYLKNYFARYAVAMIHSKMTEEEQQRIMKYFSEGTVHILVATSVVEVGVDVPNANCIVIEHAERFGLSALHQLRGRVGRGDVQSYCFLMHGDEMTECAKRRLKIMGSTADGFVIAEEDLKLRGPGDVGDTKNFEQSGYSGFRVADPVRDYPILQVAREAAFELLRKEKGSSEAR
What is the function of this protein?
Critical role in recombination and DNA repair.  Helps process Holliday junction intermediates to mature products by catalyzing branch migration.  Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity.  Unwinds branched duplex DNA (Y-DNA) (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase RecG.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecG subfamily.
Protein: RS20_HAES1
Sequence: MANIKSAKKRAVQSEKRRQHNASQRSMMRTFIKKTYAAVATGDKAVAQAAFVEMQKVVDRMASKGLIHANKAANHKSKLAAQIKKLA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: URE2_STAA9
Sequence: MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKHLDIPAGAAVRFEPGDKKEVQLVEYAGKRKIFGFRGMVNGPIDESRVYRPTDENDAYAGVFGDNGAENVNKKGGKRS
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM04_ASPFU
Sequence: MHRQSVARLTRQCHGLPLVELPPPYLAPSLHFSLIRTPVQCSSFSSTAVVAGRGRDLNKTRGVSAIHRTGPRFKLGVSKYPLPKPVSPAALEKREATPNHGLWGFFPRDRSALSTPEYDIAHGRSWSIQELREKSWEDLHCLWWVCVKERNRIATSNLERQRLKAGYGEWEARERDRTIRITQNGIKHVLRERWYAWEDAKRLYKKGYRPQDEENQE
What are the official names of this protein?
54S ribosomal protein L4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DGK1_DROME
Sequence: MNIGIAAPKWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDCEAPLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAELMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPLASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLLHHWVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKKSQMHHHQATHFQITPPDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLLCS
What is the function of this protein?
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity (By similarity).  May have a role in the development of the embryonic nervous system and the function of the adult nervous system and muscle; regulating signal transduction in neurons.
What are the official names of this protein?
Diacylglycerol kinase 1, DAG kinase 1, DGK 1, Diglyceride kinase 1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
Protein: PHZD_PSEFL
Sequence: MTGIPSIVPYALPTSRDLPANLAQWHIDPERAVLLVHDMQRYFLRPLPDALRDQVVGNAARIRQWAADNGVPVAYTAQPGSMNEEQRGLLKDFWGPGMKASPTDREVVDALAPQPGDWLLTKWRYSAFFNSDLLQRLHASGRDQLILCGVYAHVGVLISSVDAYSNDIQPFLVADAIADFSKEHHWMAMEYAASRCAMVITTDEVVL
What is the function of this protein?
Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control.  Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA).
What are the official names of this protein?
Phenazine biosynthesis protein PhzD, 2-amino-4-deoxychorismate hydrolase, Trans-2,3-dihydro-3-hydroxyanthranilic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family.
Protein: GPHB5_MOUSE
Sequence: MKLVYLVLGAVALLLLGGPDSVLSSSSGNLHTFVGCAVREFTFMAKKPGCRGLRITTDACWGRCETWEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPGVDPFYTYPMAVRCDCGACSTATTECETI
What is the function of this protein?
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production.  Plays a central role in controlling thyroid cell metabolism.
What are the official names of this protein?
Glycoprotein hormone beta-5, Thyrostimulin subunit beta.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPEA_SHESA
Sequence: MNDWSIDAARAGYNVTHWSQGFYGISDQGEVTVSPDPKNPDHKIGLNELAKDMVKAGVALPVLVRFPQILHHRVNSLCQAFDQAIQKYEYQADYLLVYPIKVNQQKTVVEEILASQASKEVPQLGLEAGSKPELMAVLAMAQKASSVIVCNGYKDNEYIRLALIGEKLGHKVYIVLEKLSELKMVLAESKRLGVKPRLGLRARLAFQGKGKWQASGGEKSKFGLSAAQILTVVDQLKQEDMLDSLQLLHFHLGSQIANIRDIRQGVSEAARFYCELRELGASINCFDVGGGLAVDYDGTRSQSNNSMNYGLSEYANNIVNVLTDICNEYEQPMPRIISESGRHLTAHHAVLITDVIGTEAYQVEEIQPPAEESPQLLHNMWQSWTEISGRADQRALIEIYHDSQSDLQEAQSLFALGQLSLAERAWAEQANLRVCHEVQGLLSTKNRYHRPIIDELNEKLADKFFVNFSLFQSLPDAWGIDQVFPVLPLSGLDKAPERRAVMLDITCDSDGIVDQYVDGQGIETTLPVPAWSAESPYLMGFFMVGAYQEILGDMHNLFGDTNSAVVSIEENGMTNIESVLAGDTVADVLRYVNLDAVDFMRTYEELVNQHIAEEERAQILEELQVGLKGYTYLEDFS
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: TSP50_HUMAN
Sequence: MGRWCQTVARGQRPRTSAPSRAGALLLLLLLLRSAGCWGAGEAPGALSTADPADQSVQCVPKATCPSSRPRLLWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRANGTHICAGTIIASQWVLTVAHCLIWRDVIYSVRVGSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDTHREKFCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPAPSRTLLLALPLPLSLLAAL
What is the function of this protein?
May be involved in proteolysis through its threonine endopeptidase activity.
What are the official names of this protein?
Probable threonine protease PRSS50, Cancer/testis antigen 20, Serine protease 50, Testis-specific protease-like protein 50.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Note=May also localize to cytoplasmic membranes.
Protein: MDH_DELAC
Sequence: XKKPVXVAVTGAAGQIGYA
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: NHAA2_CAMJ8
Sequence: MQMIKKMVLSETFPGILLIFFTFLALLCKNSSLSVIYTDFFHANFTVGFDHFQISKSLDLWINDGLIAIFFLCIGLELKYEILRGQLKNIRAVSLPIFGALGGMITPALIFAAINYSHDFAMKGWAIPTATDIAFAVGILMLLGNKIPTSLKLFLLSLAIFDDLGAIVIIALFYTDQLSALAIIICLFCIFALLLLNYYHITHLSLYVLVGVVLWIAMLKSGVHATLAGVIISLFIPLDTKNKKPYLHEVLKDLNPWVVYFILPLFAFANAGIDIRDMHLGSVFSPVSLGIILGLFLGKQLGVFTFCFIAIKLKLAKLPENIKYGKFYGICILTGIGFTMSLFIDGLAYKNSDIFEHADKLAILIASFLSAIVGFIYLKIVK
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 2, Sodium/proton antiporter NhaA 2.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS2_STRM5
Sequence: MPQVTMRQMLEAGVHFGHQTRYWNPKMAPYIFGARGKIHIINLEKTVPLFNDAMNFISSVAQKRGTVLFLGTKRSARETIKEEAERCGMPFMNQRWLGGTLTNFRTVKQSVARLKELEAGETDGTFEKLVKHEVLGLRRERDKLEASLGGIKDMNRLPDAIFVIDIGHEDIAIKEAKKLGIPVIAVVDTNYNPELVDYAIPGNDDAIRAVQLYSRAAADAVLEGKAAAPHAATVREEEFADAPAEDAKPARRAPAKKAAADKGEAQA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RUVA_BIFAA
Sequence: MIGMLRGHVESVDAVSAIIEVGGVGYEVRMPSADLASMHAGQEIKVYTSLNVSQDAITLFGFGTLASKRMFLQLQKVSGIGPKVALSLLSTLPPDRLARAVADGDATALAKAPGLGKKGAQKIILELKGSIDLSQIEGSSATASTPEDTGAEQVVEGLMSLGWHQQDAAHAVQTVCADNQIETPLNAKDVPRVLKLALTSLDRGR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ATPG_SYNS3
Sequence: MANLKEIRDRIKSVKNTRKITEAMRLVAAAKVRRAQEQVLRSRPFADRLARLLENLQARMRFEDADAPLLEQRAVQTITLMAVTGDRGLCGGYNSNIIKRTEKRFAELQRQGYKVALVLIGRKAISYFTNRNYPIQATFTGLEQVPTADEAGSIASEIFAEFLSETSDRVEIIFTKFINLVSCKPVVQTLLPLDPQGIAEADDEIFRLTTKEGRLSVEAGSAPENSQPALPSDIVFEQSPDQLLNALLPLYLQNQLLRSLQESAASELASRMTAMNNASDNAKELAKTLTLDYNKARQAAITQEILEVVGGSAAAGA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: DNAK_LEPIC
Sequence: MSKEKIIGIDLGTTNSVVSVMEGGDPVVIQNSEGARTTPSIVAFTAKGETLIGQFAKNQAITNAVNTIRSAKRFIGRRLNECESEMKHVSYKVIRSGNEGVKFETSAGEFTPQEISARVLMKMKQTAEDYLGQKVTKAVITVPAYFNDEQRQATKDAGRIAGLEVERIINEPTAAALAYGFDKKNVNSKIAVYDLGGGTFDISILELADGVFEVKSTNGDTHLGGDDFDMAIMEWMISEFKNQTGIDISADKNTVQRLKEAAEKAKIELSGTMSTQINLPFITADASGPKHLDMTLTRAKFDQLTKSLVDRTRIPCENALRDAGLKASDINEVILVGGSIRIPAVQELVKQVFGKEPNKSVNPDEVVAIGAAIQGGVLAGEVSDVLLLDVTPLSLGIETLGGVMTKLIERNTTIPTKKSQVFSTAADNQSAVSIHVLQGEREMASANRTLGRFDLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDLGTGKEQKIRIESSSGLSEDEIQKMVKDAEAHAAADKAQREVIEAKNELDTLTYSLEKTVNEAGDKIGANEKQLATDEIKRAREAIESNDKARIESAKASISKIATDIASKVYSQSAPGAEQAAAGGPNGGAGSNDQGNSTNNGEKVVDADYTVVDDEKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: TRIM5_PITPI
Sequence: MASRILMNIKEEVTCPICLELLTEPLSLDCGHSFCQACITANHKKSMLHQGERSCPLCRISYPSENLRPNRHLANIVERLREVMLSPEEGQKVDHCARHGEKLLLFCQQDGNVICWLCERSQEHRGHHTLLVEEVAQTYRENLQVALETMRQKQQDAEKLEADVREEQASWKIQIRDDKTNIMAEFKQLRDILDCEESNELQILEKEEKNILKRLTQSENDMVLQTQSMGVLISDLEHRLQGSVMELLQGVDEVIKRVKNVTLQKPKTFLNEKRRVFRAPDLKGMLQVFKELTEVQRYWVHVTLVPSHLSCAVISEDERQVRYQERIHQSFGKVKYFYGVLGSPSIRSGKHYWEVDVSNKSAWILGVCVSLKCTANRNGPRIENYQPKNGYWVIGLWNAGNYSAFQDSVKYSDFQDGSHSATYGPLIVPLFMTICPNRVGVFLDYEACTVSFFNVTSNGFLIYKFSNCRFSDSVFPYFSPMTCELPMTLCSPRS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: HAD4_BURCE
Sequence: MVDSLRACVFDAYGTLLDVHSAVMRNADEVGASAEALSMLWRQRQLEYSWTRTLMHQYADFWQLTDEALTFALRTYHLEDRKGLKDRLMSAYKELSAYPDAAETLEKLKSAGYIVAILSNGNDEMLQAALKASKLDRVLDSCLSADDLKIYKPDPRIYQFACDRLGVNPNEVCFVSSNAWDLGGAGKFGFNTVRINRQGNPPEYEFAPLKHQVNSLSELWPLLAKNVTKAA
What is the function of this protein?
Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids (PubMed:1376111).  Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-3 (PubMed:1376111).  Active with 2-halogenated carboxylic acids and converts only the S-isomer (or L-isomer) of 2-chloropropionic acid with inversion of configuration to produce R-lactate (or D-isomer) (PubMed:1376111).
What are the official names of this protein?
(S)-2-haloacid dehalogenase 4A, 2-haloalkanoic acid dehalogenase IVA, Halocarboxylic acid halidohydrolase IVA, L-2-haloacid dehalogenase IVA.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
Protein: LYSK_SULIN
Sequence: MQQEKELVKQKAKELLLDLLSIYTPSKNETNATKFFEKISNEFNLKLEILPDSNSFILGEGEILLASHVDTVPGYIEPKIENEVIYGRGAVDAKGPLISMIIAAWLLNEKGIKVMVSGLADEESTSIGAKELTLKNFNFKHIIVGEPSNGTDIVVEYRGSIQLDIMCESTPEHSSSAKSNLIVDISKKIIEVYKQPENYDKPSIVPTIIRAGESYNVTPAKLYLHFDVRYAINNKRDDLINEIKDKFQECGLKIVDETQPVKVSINNPVVKSLTRALLKQNIKPRLVRKAGTSDMNILQKITTSIATYGPGNSMLEHTNQEKITLDEIYIGVKTYMLAIEELWQKS
What is the function of this protein?
Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
What are the official names of this protein?
[LysW]-lysine/[LysW]-ornithine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. LysK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_LISIN
Sequence: MGRSLKKGPFVDDHLMKKVEAAAESEKKQVIKTWSRRSTIFPTFVGQTIAVYDGRKHVPVYVQEDMVGHKLGEFAPTRTYRGHAGDDKKTKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: UXS1_HUMAN
Sequence: MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMRSIQENGELKIESKIEEMVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARIKKGRTRHS
What is the function of this protein?
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:23656592, PubMed:22810237, PubMed:25521717).  Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:23656592, PubMed:22810237, PubMed:25521717).
What are the official names of this protein?
UDP-glucuronic acid decarboxylase 1, UDP-glucuronate decarboxylase 1, UGD, UXS-1, hUXS, hUXS1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: DAPA_PSEAE
Sequence: MIAGSMVALVTPFDAQGRLDWDSLAKLVDFHLQEGTNAIVAVGTTGESATLDVEEHIQVIRRVVDQVKGRIPVIAGTGANSTREAVALTEAAKSGGADACLLVTPYYNKPTQEGMYQHFRHIAEAVAIPQILYNVPGRTSCDMLPETVERLSKVPNIIGIKEATGDLQRAKEVIERVGKDFLVYSGDDATAVELMLLGGKGNISVTANVAPRAMSDLCAAAMRGDAAAARAINDRLMPLHKALFIESNPIPVKWALHEMGLIPEGIRLPLTWLSPRCHEPLRQAMRQTGVLA
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_NEUCR
Sequence: MSEQKETVHIGTRRSALALRQVDLVIAALQPHHPNVHFQVHALATLGDKNQTASLPSLGKGLWTNELEAKLFNKEVDFIVHCLKDMPTTLPEGGKIGVVTEREDPRDVVVMKKKWAEQGKYKSLADLPEGAIVGTSSVRRAAQLRRRYPGLVFKDVRGNIETRMRKCDEEDYDCIILAAAGLLRMGYDERIAQWLDSTTEGGGMLHAVGQGALAMEIREGDEKTLEIIKPLCHEKTMVATFAERAVMRTLEGGCSVPIGVETKWVGEDQLQLKVTVVSLDGKESVDGQSVEVIKTIEEAEAMGQKLAEDLAKRGAQKILDFVNQGRASGGALKIGDL
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: FIS_SALHS
Sequence: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.