PharMolix/UniProtQA huggingface dataset:
Protein: FOLD_ANAPZ
Sequence: MGIYENNIIDGKAAAADLLGRLKVVMEGLKEEHGLFPSLVVIIVGDDPASRLYVGNKQRKAEELGINSKTIALPYETTQEELLGIIQELNEDENVHGILVQLPLPKHIDKILIINAIDPEKDVDGFHNANAGKLLTGEMDCMVPCTPQGCIYLIKKVMPVLSSKRAVVIGRSNIVGKPVALLLMYENCTVSILHSATANIEEHCRDAEIIIAAVGKARMVKSEWVSPGAVVIDVGINLITSESKNRFVGDVDFESVRDKVAAITPVPGGVGPMTIAFLLVNTVLGACRQKGIKQYKNIKSSVLQ
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: KKLC1_MACFA
Sequence: MNVYLLLASGILCALMTVFWKYRRFQRNTGEMSSNSTALALVRPSSTGLINSNTDNNLSVYDLSRDILNNFPHSIAMQKRILVNLTTVENKLVELEHILVSKGFRSASAHRKST
What are the official names of this protein?
Kita-kyushu lung cancer antigen 1 homolog.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: ADE_PSEAB
Sequence: MYEWLNALPKAELHLHLEGTLEPELLFALAERNRIALPWNDVETLRKAYAFNNLQEFLDLYYAGADVLRTEQDFYDLTWAYLQKCKAQNVVHVEPFFDPQTHTDRGIPFEVVLAGIRAALQDGEKLLGIRHGLILSFLRHLSEEQAQKTLDQALPFRDAFIAVGLDSSEVGHPPSKFQRVFDRARSEGFLTVAHAGEEGPPEYIWEALDLLKVERIDHGVRAFEDERLMRRLIDEQIPLTVCPLSNTKLCVFDDMSQHTILDMLERGVKVTVNSDDPAYFGGYVTENFHALQQSLGMTEEQARRLAQNSLDARLVK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenine to hypoxanthine.  Plays an important role in the purine salvage pathway and in nitrogen catabolism.
What are the official names of this protein?
Adenine deaminase, ADE, Adenine aminohydrolase, AAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Protein: ATPD_SALG2
Sequence: MSEFVTVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENNRLNALPDVLEQFIHLRAASEATSEVEVTSATALSEEQLSKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATPA_CRUWA
Sequence: MVTIRADEISNIIRERIEQYNREVTIVNTGTVLQVGDGIARIYGLDEVMAGELVEFAEGTIGIALNLESNNVGVVLMGDGLMIQEGSSVKATGKIAQIPVSEAYLGRVINALANPIDGRGKISASESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAIGQKASSVAQVVTSLQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYREQHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSQLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFAQFSSDLDKATQNQLARGQRLRELLKQSQSAPLTVEEQIMTIYTGTNGYLDGLEIGQVRKFLVQLRTYLKTNKPQFQEIIASTKTLTAEAESFLKEGIQEQLERFLLQEKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: FETP_YERPA
Sequence: MSRTIFCTFLKKDAERQDFQLYPGEIGKRIYNEISKEAWSQWITKQTMLINEKKLSMMNIEDRKLLEQEMVNFLFEGQDVHIAGYTPPSK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: FPG_XYLFT
Sequence: MPELPEVETTLRGLLPYLTNQLIYSLTLRRRTLRWDIPSHIESRLPGHRITTVCRRAKYLLIDTNAGGSLIIHLGMSGTLRLLAPETPLRPHDHVDIMLNNRRVLRFNDPRRFGCLLWQEDGQIHPLLQRLGCEPLSDSFNGDYLYQCSRARNVSVKTFLMDQRIVVGVGNIYAAESLFRAGISPLCEADKISLQRYRRLAEVVKDILLYAINRGGTTLRDFLSPDGRPGYFKQELFVYGRQQQPCKQCGSLLRQTTIRQRTTVWCGHCQG
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: YFBU_SHIFL
Sequence: MEMTNAQRLILSNQYKMMTMLDPANAERYRRLQTIIERGYGLQMRELDREFGELKEETCRTIIDIMDMYHALYVSWSNLQDQQSIDERRVTFLGFDAATEARYLGYVRFMVNVEGRYTHFDAGTHGFNAQTPMWEKYQRMLNVWHACPRQYHLSANEINQIINA
What are the official names of this protein?
UPF0304 protein YfbU.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: RS10_METS4
Sequence: MNGQNIRIRLKAFDHRILDSSTREIVSTAKRTGAQVRGPIPLPTRIERFTVNRSPHIDKKSREQFEMRTHKRVLDIVDPTPQTVDALMKLDLAAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: SYUA_PANPA
Sequence: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
What is the function of this protein?
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity).  Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity).  Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity).  Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity).  This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity).  Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
What are the official names of this protein?
Alpha-synuclein.
What is the protein family that this protein belongs to?
Belongs to the synuclein family.
Protein: SYI_STRZP
Sequence: MKLKDTLNLGKTAFPMRAGLPTKEPVWQKEWEDAKLYQRRQELNEGKPHFVLHDGPPYANGNIHVGHAMNHISKDIIIRSKSMSGFNAPYIPGWDTHGLPIEQVLAKQGVKRKEMDLVEYLKLCREYALSQVYKQRDDFKRLGMSGDWENLYVTLTPDYEAAQIRVFGEMANKGYIYRGAKPVYWSWSSESALAEAEIEYHDLVSTSLYYANKVKDGKGILDTDTYIVVWTTTPFTITASRGLTVGADIDYVLVQPASETRKFVVAAELLTSLSEKFGWADVQVLATYRGQELNHIVTEHPWDTAVDELVILGDHVTTDSGTGIVHTAPGFGEDDYNVGIANGLEVAVTVDERGIMMANAGPEFEGQFYDKVVPTVIEKLGNLLLAQEEISHSYPFDWRTKKPIIWRAVPQWFASVSKFRQEILDAIDKVKFHTEWGKVRLYNMIRDRGDWVISRQRAWGVPLPIFYAEDGTAIMTAETIEHVAQLFEVHGSSIWWERDAKNLLPEGFTHPGSPNGEFKKETDIMDVWFDSGSSWNGVLVNRPNLTYPADLYLEGSDQYRGWFNSSLITSVANHGVAPYKQILSQGFTLDGKGEKMSKSLGNTIAPSDVEKQFGAEILRLWVTSVDSSNDVRISMDILSQVSETYRKIRNTLRFLIANTSDFNPAQDVVAYDELRSVDKYMTIRFNQLVKTIRDAYADFEFLTIYKALVNFINVDLSAFYLDFAKDVVYIEGAKSLERRQMQTVFYDILVKITKLLTPILPHTAEEIWSYLEFEAEDFVQLSELPEAQTFANQEEVLDTWAAFMDFRGQAQKALEEARNAKVIGKSLEAHLTVYPNEVVKTLLEAVNSNVAQLLIVSDLTIAEGPAPEAAVSFEDVAFTVERAAGQVCDRCRRIDPTTAERSYQAVICDHCASIVEENFAEAVAEGFEEK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCE1_SCHPO
Sequence: MAPSEKDIEEVSVPGVLAPRDDVRVLKTRIAKLLGTSPDTFPGSQPVSFSKKHLQALKEKNYFVCEKSDGIRCLLYMTEHPRYENRPSVYLFDRKMNFYHVEKIFYPVENDKSGKKYHVDTLLDGELVLDIYPGGKKQLRYLVFDCLACDGIVYMSRLLDKRLGIFAKSIQKPLDEYTKTHMRETAIFPFLTSLKKMELGHGILKLFNEVIPRLRHGNDGLIFTCTETPYVSGTDQSLLKWKPKEMNTIDFMLKLEFAQPEEGDIDYSAMPEFQLGVWEGRNMYSFFAFMYVDEKEWEKLKSFNVPLSERIVECYLDDENRWRFLRFRDDKRDANHISTVKSVLQSIEDGVSKEDLLKEMPIIREAYYNRKKPSVTKRKLDETSNDDAPAIKKVAKESEKEI
What is the function of this protein?
Second step of mRNA capping.  Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.
What are the official names of this protein?
mRNA-capping enzyme subunit alpha, GTP--RNA guanylyltransferase, GTase, mRNA guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic GTase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TPS6_DICDI
Sequence: MSLSLGDIKFPDNWDLIPNEKNYIDYVYKESIELEVWRPNNKRDLMAHNNVVSLAKYFWPHVDFNRLVMGGELMVWFFSFDDVLDAGIYTDEKQMDLVKRMDNVFINGTVESDATGPEKMALHLRKKCEVMCGKRRKDTFNRFISSCVQWVDSIIPFNKLRSAQGTSPHLELYSYLRKVNIGAYPCVTLTEVMLDHEIEYYIWSDPKWIKMNEDIAIITTLINDLVSYEKEVNDQAGDLNPLYFLQNQKNIPLPDSYKQVVDLIDFWVKDYQTMEQSLLNEMEFKDSKQRSDMEFILEHLRYLASGSKKWSMQTPRYCSPTSPFIEMRTKPSTPVMNSTKKQKIDHVPSQSFISTPIDLNN
What is the function of this protein?
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene (2S,3R,6S,9S)-(-)-protoillud-7-ene.
What are the official names of this protein?
Terpene synthase 6.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: RL7_BORA1
Sequence: MALNKAEILDAIAGMTVLELSELIKEMEEKFGVSAAAAAVAVAAPAAGGAAAAAEEQTEFTVVLVEAGANKVSVIKAVRELTGLGLKEAKDLVDGAPKPVKEALPKADAEAAKKKLEEAGAKVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: LSRC_YERPB
Sequence: MLKFIQNNREGTALLAILTLFALLGIIDRNYFSLQTFTMIFSSAQILILLAIGATLVMLTRNIDVSVGSITGLCAVTVGMALNAGFGLVASCLFALLVGMVAGFFNGILVTWLRIPAIVATLGTLGLYRGLMLLLTGGKWIEGLPADLKSLSTPILFSISPIGWLTMLLILSMAWLLGNTAFGRSFYATGDNLQGARQLGVRTDSIRIFAFSMNGVMAALAGIVFASQIGFIPNQTGNGLEMKAIAACVLGGISLLGGTGTIIGAILGAFLLTQIDSVLVLLRLPAWWNDFIAGLVLLGVLVFDGRLRCAVERNIRQQKYARFTAQAIISDKKPTVSDNNPAASNKKKAAL
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Autoinducer 2 import system permease protein LsrC, AI-2 import system permease protein LsrC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOC_BORBZ
Sequence: MKEIKDFERIKIKIASPDQIRNWSYGEVKKSETINYRTLRPEKDGLFCERIFGTTKEWECYCGKFKSVRYKGIICDRCNVEVTHFKVRRERMGHIELAAPVAHIWYYKYIPSRIGLLLDITASSLNSILYYEKYVVIEPGDTDLKKMQLLNEDEYIEARERYGMSFNASMGAEAIKTLLENLDLDELSSKLRIQMIDKDDKTDKKLLRRLEIIENFKISGNKPEWMIMEVLPVIPPEIRPMVQLDGGRFATSDLNDLYRRVINRNNRLRKLLLLNAPEIIVRNEKRMLQESVDSLFDNSHKRKVVKGSSSRPLKSLSDALKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPAKMALELFKPFVIRRLIESEAVFNIKRAKNLIEQEVDEVWQILDLVIKEHPILLNRAPTLHRLGIQAFEPVLVEGKAIKLHPLVCHAYNADFDGDQMAVHVPLTPAAQAESWALMLSTNNLLNPANGHPIVFPSQDIVLGLYYLTMEKKNVIGEGKKFLNFNNVILAINNRSLDYNASIYVKIDGEYKKTTAGRVIFNEALPKGIEFVNKTLSDLELQILISKVYVVHGSSTVIEMLDIIKELGFRYATKFGCTISMSDIIVPDEKRTYVERANKEIAKIQNDYAKGVITGEERYNNVVSVWLKTNEELTNKMMEILKKDRDGFNVIYMMADSGARGSRNQIRQLAGMRGLMAKTSGDIIELPIISNFKEGLSVIEFFISTNGARKGLADTALKTADAGYLTRRLVDIAQDVVVRIEDCGTINGIKVETVKNGEEILESLKEKAVGSYSIERIKNPITGEIVLDANEEISEAKIELLEKIGIEKLVIRSVLTCEAEHGVCQKCYGRDFSKNKPVNIGEAVGIIAAQSIGQPGTQLTMRTFHIGGVAQAGSEDDKISLKNAFILNGIEGFNVRVDNGILFTRKGTLKIINVFYEEKIKNIKEIKVLDSQRVIKGIPLFIDKKGSEILSSYIGYVKLRDDNFFIVSEEQEVSLKAGTKLEIEVGDYVESGKVIGTFDPFAEPIIAEVKGKIKFKDIILGTTLKEEINTETGNVEKRITDNVFESLDPRIFIIDSSGMEVASYVLPGDAYLQVEDGQSINIGDIIAKLSKGSEKTQDITGGLPRVNDLFETRIPKNLTEMAKVSGIVQFKSIQKGKRLINILDEYGVEHKHYIPAGKHLLVRDGDVVKAGDMLCDGRINPHDVLEILGGISLQEFLLAEIQDVYRKQGVSINDKHIGVIIKQMMKKVKIVAVGDTNFVYGQKVDKHTFYEQNRKVIKQGGEPAIASPILIGVTKTSLNIDSFISAASFQETTKVLTDASIAGKIDDLRGLKENVVIGHLIPTGTGMGLYKKIKVSENIDSEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PRMG_GORST
Sequence: MAKELRYNAEARLRLERGVNALADAVKVTLGPKGRNAVLEKLTGPPTITNDGVTIAREIQLRDPFANMGAQLVKEVAMKTNGVVGDGTTTATVLAQAMVREGLRAVEQGANPMRVRRGIERAVTAVLGSLTEQAVQIGGRSDLERIARWPPATTRWSVRSSPPPSNTSARTASSPPRRATHSGCRSRSSTASEFDHGYISGYMVTNPERMEAVLDNPVVLLTNKKITSVQEIMPAIEVAKRADRPLLVLAEDVDGPALQLLVGGNMHNTMRSVVVRAPGFGHRRIAELEDLSVALGGHVIAKDTGIELSEVSMEHLGTVMRVTVTENETTIVGAHGEQELVDARVRHLEAQLERARIDADRDALELRIARMTGRVAVIRVGGVTSVELKER
What is the function of this protein?
Probably plays an essential role in the productive folding of PrmA and PrmC, and thus in the formation of the active PrmABCD complex.
What are the official names of this protein?
Probable chaperonin-like protein PrmG.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
Protein: CAR4_DICDI
Sequence: MKVLQEINLTYSILVIADFSSIFGCLLVLIAFKKLKLLRNHITRVIACFCVSSLLKDIISTGLTLSLGPQNEAGSTSFQCYLYAITITYGSLACWLWTLCLAFSIYNLIVKREPEPEKYEKFYHGVCWTIPLICVIVMLAKKTIEPVGNWCWISEKYVGYRFGLFYGPFFAIWIISAVLVGLTSRYTYSVIRNSVSDNKDKHMTYQFKLINYIIVFLLCWVFAIVNRILNGLGYYPTLPNILHTYFSVSHGFFASVTFIYNNPLMWRYWGSKIFLIFAKFGYFVELQRRLDRNKNNNNPSPILNSYAATVYHSSTIESLSLQHNNDISNDNQQQQQQQQTPQQPQQQFQQQQSPTVIEMQNLKQDQNIENNEQNENCYNTIDTNIEINTNKLNDNSFEITQPSNDLNTIENNNNYNNNNNNNNNNSLVIEKEKDEREKKDNKF
What is the function of this protein?
Receptor for cAMP.  Regulates axial patterning and cellular differentiation during late development.  The activity of this receptor is mediated by G proteins.
What are the official names of this protein?
Cyclic AMP receptor 4, cAMP receptor 4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 5 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NS1_I02A0
Sequence: MDSNTVSSFQVDCFLWHVRKRFADQEMGDAPFLDRLRRDQKSLGGRGSTLGLDIETATRAGKQIVERILEEESDEALKMTIASAPASRYLTDMTLEEMSRDWFMLMPKQKVAGSLCIRMDQAIMDKNITLKANFSIIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTDEDVKNAIGVLIGGLEWNDNTVRVSETLQRFAWRSSNEDRRPPLPTKQKRKMARTIESEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: FADB_SHEFN
Sequence: MIYQSPTIQVELLEDNIAKLCFNAQGSVNKFDRETIASLDAALDSIKQNTNIKALLLTSAKSTFIVGADITEFLTLFQQDDATLLAWVEQANAVFNKLEDLPFPTASAINGFALGGGCETILATDLRVADTNARIGLPETKLGLIPGFGGTVRLPRVIGADNALEWITTAKDQRPEDALKVGAIDAVVAPENLEAAAIQMLHDALNGSLDWQARRTKKQSPLQLPKLEAMMSFATAKGMVFSVAGKHYPAPMAAVNVVEQAAGLDRDGALKVEALAFIKLAKTDVAQALIGIFLNDQFVKGKAKKAGKLAKDVNQAAVLGAGIMGGGIAYQSASKGTPIVMKDIAQPALELGLNEAAKILTTQVARGRSTPEKMAKVLNNITPSLDYAAIKNSDIVVEAVVEHPKVKATVLAEVEGYVSEDAIIASNTSTISINLLAKSLKKPERFCGMHFFNPVHKMPLVEIIRGEHSSEETIATVVAYASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSGLLAEGADFAAVDKVMEKQFGWPMGPAYLLDVVGLDTGHHAQAVMAEGFPDRMGKNGKDAIDIMFENKRLGQKNTKGFYAYSVDRRGKPKKDIDPTSYELLSAEFGELKAFESDDIIARCMIPMIIETVRCLEEGIIASPAEGDMGLVYGIGFPPFRGGVFRYLDTMGVANFVALADKYAHLGGLYQVTDAMRALAANNGSYYQA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: KDM7A_HUMAN
Sequence: MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHGSSLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPIVCPVSRSSNEATSPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDILSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQPFADQSLYTADSENEEDKRRTKKAKMKIEESSGVEGVEHEESQKPLNGFFTRVKSELRSRSSGYSDISESEDSGPECTALKSIFTTEESESSGDEKKQEITSNFKEESNVMRNFLQKSQKPSRSEIPIKRECPTSTSTEEEAIQGMLSMAGLHYSTCLQRQIQSTDCSGERNSLQDPSSCHGSNHEVRQLYRYDKPVECGYHVKTEDPDLRTSSWIKQFDTSRFHPQDLSRSQKCIRKEGSSEISQRVQSRNYVDSSGSSLQNGKYMQNSNLTSGACQISNGSLSPERPVGETSFSVPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV
What is the function of this protein?
Histone demethylase required for brain development.  Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853).  Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2.  Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638).  Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853).
What are the official names of this protein?
Lysine-specific demethylase 7A, JmjC domain-containing histone demethylation protein 1D, Lysine-specific demethylase 7, [histone H3]-dimethyl-L-lysine9 demethylase 7A.
What is the protein family that this protein belongs to?
Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNFE_STUST
Sequence: MSSQCGSADVTAPKPKGLFNYFSSALWDYNVALVQMLALCPALAVTTTATNGLGMGLATTLVLMITNAIISALRHSISPAVRNPLMIGIIAGVVTLIDMAINAWMHELYKVLGLFIALIVTNCAVLGRAESFCSRNPVLPSILDGRRAWASGFTWVLVVIGGIREILGQRARCSPRPRLLLGEHFRWLEITVLPGFQGILLAILPPGAFIVLGFVLAFKRVVDRRRAERRIRTHGELVVLQ
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
Protein: IKBH1_MDBVW
Sequence: MMRYYIYVQYWKRFLRLVRSFHWATSNVLLFKSDFGDTFKMRDYNLYEMLSARNGSGGTYFHEACQANSIALLWRAAGMLDESHPRILNIRDYKGAQCTHIIATSNVSCSIDMMNIVLQLGADINGQEGLAGLTPLHICVNKKNYALAEWLCQAPGIDVKVENFGKETPYDLACKMEDRKMMKIFEERSKKM
What is the function of this protein?
Suppresses the host immune response through NF-kappa-B inactivation.  Possesses ankyrin repeat domains required for NF-kappa-B binding but lacks the regulatory regions required for dissociation from NF-kappa-B and degradation.  Therefore, prevents host NF-kappa-B release and subsequent activation.
What are the official names of this protein?
I-Kappa-B like protein H1.
What is the protein family that this protein belongs to?
Belongs to the polydnaviridae I-Kappa-B-like protein family.
Protein: ARNA_SODGM
Sequence: MKAVIFAYHDMGCVGVTALINAGYTIEAIITHPDAPSEKTFFGSVARIAAEHNIPVFVPDDVNHPLWIARIKALAPDVIFSFYYRQLLCQDILSLPTVGAFNLHGSLLPRYRGRSPLNWVLVNGEQETGVTLHRMTARADAGAILAQRSVAITLQDDALTLHRKLCEAAAGVLEKVLPAIREQRCTETPQDESIASYVGHRTPEDGRIDWGQPAATLANLVRAVTDPWPGAFSYAGGEKFIIWKAQVRPNSADAQPGTVLSIDPLVIACGSDALEVQTGQSQQGVYMQGGQLAHALGLVKGALLNPRPLVSHKRRTRVLILGVNGFIGNHLTERLLRDGNYEIYGLDIGTDAISRFMVNPLFHFVEGDISIHSEWIEYHIKKCDIVLPLVAIATPIEYTRNPLRVFELDFEENLKIIRHCVKYQKRIIFPSTSEVYGMCTDPVFDEDDSSLIVGPINKQRWIYSVSKQLLDRVLWAYGEKEGLRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSHIKLVDGGAQKRCFTDISDGIEALFRIIENKDNNCDGQIINIGNPDNEASIRQLAELLLASFERHPLRQHFPPFAGFRDVESSSYYGKGYQDVEHRKPSIRNAKRLLGWAPSVPMAQTIDETLDFFLQTVDLPDAAQ
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.