PharMolix/UniProtQA huggingface dataset:
Protein: P100_HHV7J
Sequence: MKMSHLPFAWISDEAKCFLSRFFENISSLPVVDIRENPWILSQCIVKTGNSINNVKTLYNNLILWIYFHQTLCKKKPDYEEVWQEILKVQKILKDYLEQRQMITDYSSLTSFNKVGFETEFKNVAKDLLKLGSFLRWGTVTHAADYVNLTTEERAEIGENLQKAKNNMLSFTIYQIVDPWNENGYYVTNINRLLYLGNLLITLHGSWMNMEKLALNTINEKKNAILKAIENNKNFVSIYSYQILSLPLTSHRVTSFFKILTEDFDVITKSLELHALPVKSTWDDRVKFTPEPIQTFKVLTDLSKSSLSNQFESSSKKTSHGSSFNPEPFIKTEQRSNNTLSKDLFVGSEDGLLSSVKKDSMILDEPRNSTSINNSKKMHRILQTEILDLTDQTMHRPEDKVNQFNEIAVAPDGINQVIDTLSKLDLHNSNKVIDIVSSPKVNVVQLPKNKIDYHSTFFLPENEVNRQNGVQSRDQLSKNSTNDLQKILELRERIKTIKQNNEDIFKLPSEKRRKEIVHENLQSFDDEHNEMSLPPQDQKSIKQKNGNKANSSTKTLNMIGTNDVNASMKEKESASSAKKNQLVKDVKWTPSSSLLDLSRRNDLLQKELFESGLGEKVKKLLTDFTDTISLEERSLKDVLEPPKKTDVSNIATFNDNNLKNLLNSRKRDPLFQNFSFTEKMQPVRSPFFLPNAEIQDFDSGSLLTGKETQNTIFGASKAQENGDKDLIDLENSVQKDDDIVNKLVSHLTHSEEDVV
What are the official names of this protein?
Large structural phosphoprotein, 100 kDa phosphoprotein, pp100.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae large structural phosphoprotein family.
What are the subcellular locations of this protein?
Virion tegument. Note=Also found in dense bodies.
Protein: LMBD1_RAT
Sequence: MAAAAADLVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWANANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQVKTALKYTLGFVVICALLLLVGAFVPLNLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLSARDRRTLKQCEERLRTLRKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIVFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYVFLHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA
What is the function of this protein?
Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors.  Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome.  Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity).  Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity).  Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity).  Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity).
What are the official names of this protein?
Lysosomal cobalamin transport escort protein LMBD1, LMBD1, LMBR1 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the LIMR family. LMBRD1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle.
Protein: TMIE_HUMAN
Sequence: MAGWPGAGPLCVLGGAALGVCLAGVAGQLVEPSTAPPKPKPPPLTKETVVFWDMRLWHVVGIFSLFVLSIIITLCCVFNCRVPRTRKEIEARYLQRKAAKMYTDKLETVPPLNELTEVPGEDKKKKKKKKKDSVDTVAIKVEEDEKNEAKKKKGEK
What is the function of this protein?
Unknown.  The protein may play some role in a cellular membrane location.  May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking.  Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain.
What are the official names of this protein?
Transmembrane inner ear expressed protein.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CADHK_CHICK
Sequence: LRRQKRDWVIPPIKVPENERGPFPKNLVQIKSNRDREAKIFYSITGQGADAPPEGIFTIEKETGWMKVTQPLDREHINKYHLYSHAVSENGKPVEEPMEIIVTVTDQNDNKPQFTQEVFRGSVPEGALPGTSVMRVNATDADDDVETYNGVIAYSILSQEPREPHPHMFTVNRATGTLSVIASGLDRERVREYTLTMQAADLDGQGLTTTALAVIEITDVNDNAPEFDPKTYEAAVPENEAELEVARLATTDLDEPHTPAWRAVYSIVRGNEGGAFTITTDPASNEGVLRTAKGLDYEAKRQFVLHVAVVNEAPFAIKLPTATATVMVSVEDVNEAPVFDPPLRLAQVPEDVPLGQPLASYTAQDPDRAQQQRIKYVMGSDPAGWLAVHPENGLITAREQLDRESPFTKNSTYMAVLLAVDDGLPPATGTGTLLLTLLDVNDHGPEPEPRDIVICNRSPVPQVLTITDRDLPPNTGPFRAELSHGSGDSWAVEVGNGGDTVALWLTEPLEQNLYSVYLRLFDRQGKDQVTVIRAQVCDCQGRVESCAQKPRVDTGVPIVLAVLGAVLALLLVLLLLLLLVRRRKVVKEPLLLPEDDTRDNIFYYGEEGGGEEDQDYDLSQLHRGLDARPEVIRNDVAPPLMAAPQYRPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGGGSEATSLSSLNSSASDQDQDYDYLNEWGNRFKKLAELYGGGEDEE
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.  B-cadherin may have important functions in neurogenesis, in at least some epithelia, and in embryogenesis.
What are the official names of this protein?
B-cadherin, K-CAM protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: IFT25_HUMAN
Sequence: MRKIDLCLSSEGSEVILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFHKHVRIERLVIQSYFVQTLKIEKSTSKEPVDFEQWIEKDLVHTEGQLQNEEIVAHDGSATYLRFIIVSAFDHFASVHSVSAEGTVVSNLSS
What is the function of this protein?
Component of the IFT complex B required for sonic hedgehog/SHH signaling.  May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium.  Not required for ciliary assembly.  Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis.  Essential for male fertility, spermiogenesis and sperm flagella formation.  Plays a role in the early development of the kidney.  May be involved in the regulation of ureteric bud initiation (By similarity).
What are the official names of this protein?
Intraflagellar transport protein 25 homolog, Heat shock protein beta-11, Hspb11, Placental protein 25, PP25.
What is the protein family that this protein belongs to?
Belongs to the IFT25 family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: APH1_ARATH
Sequence: MTVAAGIGYALVALGPSLSLFVSVISRKPFLILTVLSSTLLWLVSLIILSGLWRPFLPLKANVWWPYALLVITSVCFQEGLRFLFWKVYKRLEDVLDSFADRISRPRLFLTDKLQIALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVERCSKVPFFLISAIIALAFVTIHTFSMVIAFEGYAKGNKVDQIIVPVIHLTAGMLTLVNFASEGCVIGVPLLYLVASLTLVHCGKMVWQRLLESRNQSSASR
What is the function of this protein?
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.
What are the official names of this protein?
Gamma-secretase subunit APH1-like.
What is the protein family that this protein belongs to?
Belongs to the APH-1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NTPTH_PYRNV
Sequence: MTSRERAESKVGITGMPGVGKTTLAMEVANLARRRMTVCGFITLEVREAGRRVGFDVYDISTGSRVPLARVGAGAVTVGKYVVDLSACDVIKRILDAASCDLLVVDEIGAMEVKCPNFLVSLEKAVKSSPRVLAVVHRNYLDVAKRLGIEVLWLSRENREAVREEVLRKLGLPLA
What is the function of this protein?
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP.  May hydrolyze nucleoside diphosphates with lower efficiency.
What are the official names of this protein?
Nucleoside-triphosphatase THEP1, NTPase THEP1, Nucleoside triphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the THEP1 NTPase family.
Protein: RL20_BURO1
Sequence: MPRVKRGVTARARHKKIINLAKGYRGRRNNVYRIAKQAVMRAGQYAYRDRRNKKRVFRALWITRINAAVRQHDMTYSVFINGLKKASIELDRKVLADMAVFDKAAFAAIVKQVKAAVAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RUVA_LISW6
Sequence: MYDYIKGKVTTITPEYIVVEAGQIGYQIITGNPFSFQRLEGSEAQVFLYQHVREDNISLFGFQSTEERYLFKKLLSVSGIGPKSALAIIASGDVVPLITAIESEDDVYLTKFPSVGKKTARQIILDLKGKLADVVASEIVFKAPENDIVHGLSPQLEEAVLALEALGYSTKELKKVIPKLSKENDLTSDAYIKLALRLMTK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PXPB_ECOLI
Sequence: MQRARCYLIGETAVVLELEPPVTLASQKRIWRLAQRLVDMPNVVEAIPGMNNITVILRNPESLALDAIERLQRWWEESEALEPESRFIEIPVVYGGAGGPDLAVVAAHCGLSEKQVVELHSSVEYVVWFLGFQPGFPYLGSLPEQLHTPRRAEPRLLVPAGSVGIGGPQTGVYPLATPGGWQLIGHTSLSLFDPARDEPILLRPGDSVRFVPQKEGVC
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit B, 5-OPase subunit B, 5-oxoprolinase (ATP-hydrolyzing) subunit B.
What is the protein family that this protein belongs to?
Belongs to the PxpB family.
Protein: IVBL_DABSI
Sequence: FGTYGHPRPRFYYNP
What is the function of this protein?
Does not inhibit chymotrypsin or trypsin.
What are the official names of this protein?
BPTI-like protein.
What are the subcellular locations of this protein?
Secreted.
Protein: FAU1_SACS2
Sequence: MKGRVRIRGIYATALTSIFSSLSYEIVQQSVEISERFMQEINNLSADITIKDFEDDRGKIIVMGNGIIEDDLRNVFKYSFHWRSPVKLYSVIEIDESCTYANFKVEPCLREGIVIKPPYDGKIILSETKAVSKYAIVWRGKGITTFSEHIVDEEEKMRLLTLSLPLNRKGYNVKWRSNAKYVALNELKEDLERLILRYENREFRDQGEDFYLITLSLPDKLYLDEVRKNVVDTVKYHHMLKLSYNREVDSLEKDKKGSLGKLLEGLISDFLKIEHIKADGKVIYLRGGKVIEKEVNDNGYRIVLRREFEGNGILDGIGKKIEEGDYDIVEYNSDKWYQIHKYYSGIDNSLKGVYINISTPPELLRGKIRYLDLEIDIAIRDSEIALLDEDELNKKSIYMPSSLVNKAKEVVNYLINRIQQNKLS
What is the function of this protein?
Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs.  Binds to RNA in loop regions with AU-rich sequences.
What are the official names of this protein?
Probable ribonuclease FAU-1, RNA-binding protein FAU-1.
What is the protein family that this protein belongs to?
Belongs to the FAU-1 family.
Protein: PYRF_METPB
Sequence: MPESADPRDRLIVALDLPDVAAAERLVARIGDAATFYKIGYRLAYAGGLDFAARLAREGKKTFLDLKLHDIGNTVEEGVRSASALGATFLTVHAYPQTMRAAVRGRGPGLKILAVTVLTSYDDADAAEAGYALPVADLVAQRASQAAAIGIDGIVCAAAEAGAVRGRIGPSGLIVTPGIRPAGAEAGDQKRVMTPGQARAAGIDHVVVGRPITGAGDPRAVARTIVAEMENV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: DDX55_DANRE
Sequence: MENITDGKWGSLPVKLHDNILQTLKELGFTYMTPVQSACIPLFMSNKDVAAEAVTGSGKTLAFVIPALEILLKREEKLKKMQVGALIITPTRELAMQISEVMGRFLQGFPQFTQILLIGGSNPIEDVEKLKTQGANIIIATPGRLEDMFRRKADGLDLATAVKSLDVLVLDEADRLLDMGFEASLNTILGYLPKQRRTGLFSATQTQELEKLVRAGLRNPVRITVKEKGVAASSVQKTPAKLSNYYTMCRAEEKFNTLVAFLRQHKHEKQLVFFSTCACVEYFGKALEVLVKNVSIHCIHGKMKHKRNKIFADFRALKSGILVCTDVMARGIDIPEVNWVLQYDPPSSASSFVHRCGRTARIGNQGNALVFLLPMEESYVNFLSINQKCPLQSFSSVKDVVDVLPKLKAMALGDRAMFEKGMRAFVSYVQAYAKHECSLIFRIKDLDFAALARGFALLRLPKMPELRGKTFPDFKAEAIDTDTIRFKDKNREKQRQKWLAEQKEKEVPLRKNFIKNKAWSKQKIKKDRKKKRLPKAKLDQDSDAAEEDLNELMNDTRLLKKLKKGKITEEDFDKQMSSTDKHKPAGIDSSDGD
What is the function of this protein?
Probable ATP-binding RNA helicase.  Plays an essential role in early embryonic development.
What are the official names of this protein?
ATP-dependent RNA helicase DDX55, DEAD box protein 55.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Protein: RIPD1_PHYDI
Sequence: ANIVFDVESATTGTYSTFLTSF
What is the function of this protein?
Nicks pBR322 dsDNA.  Has adenine polynucleotide glycosidase activity on herring sperm ssDNA.
What are the official names of this protein?
Dioicin-1, Ribosome-inactivating protein, rRNA N-glycosidase.
What is the protein family that this protein belongs to?
Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space. Golgi apparatus. Vacuole.
Protein: PSAJ_CRYJA
Sequence: MQDIKTYLSTAPVLAALSLGFLAGLLIEINRFFPDALIFPFF
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CLT1_ARATH
Sequence: MATTSSDRLIAGLTASIGSIESRYANPAQSVSLICRNQINGAPPIVLRSSRRSRLWLIEAIPPAKSWNGSNDGDEDIKKSDTRNYAIGGTGGHAVAGKDDRTMEIVIAAATTAALGVGNRVLYKLALIPLKQYPFFLAQLSTFGYVAVYFSILYFRYRAGIVTKEMLSVPKLPFLIVGVLESLALAAGMAAASNLSGPSTTVLSQTFLVWQILFSIIFLGRRYRINQILGCTLVAFGVIVSVASGSGAAHSFKDTGILWSLLMVFSFLLQGADTVMKEVIFLDSKKRLKGASLDLFVVNSYGSIFQVICIALLLPFLSKLWGIPFNQLPSYIRDGGACFLNIGSRITGCEGAPLLPVMFVMMNMAYNISLLRLIKISSAVVSSLASTVSVPIAVYCFTLPLPYLGVASTLPRGFVAGTIILVVGMLLYAWTPSTNTSDSIIPSPPST
What is the function of this protein?
Involved in thiol transport from the plastid to the cytosol.  Transports probably both glutathione (GSH) and its precursor, gamma-glutamylcysteine (gamma-EC).  Exhibits some functional redundancy with CLT3 in maintaining the root GSH pool.
What are the official names of this protein?
Protein CLT1, chloroplastic, CRT-like transporter 1, Chloroquine-resistance transporter-like transporter 1.
What is the protein family that this protein belongs to?
Belongs to the CRT-like transporter family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: ACCA_CAMLR
Sequence: MASYLDFEKNIQQIDEDLANAKIKGDDEAVKILEKNLEKETQKVYKNLSDYQRLQLARHPDRPYALDYIQAILSDAYEIHGDRAFRDDPAIVCYAGYIGGKKIIVIGEQKGRGTKDKLHRNFGMPHPEGYRKALRVAKMAEKFNIPVLFLVDTPGAYPGVGAEERGQSEAIARNLYELSALKTITIAVVIGEGGSGGALAIGVADKLAMMKNSVFSVISPEGCAAILWNDPSKSEAATKAMKVTADDLKTQGLIDDVIEEPMSGAHRDKENAIKNLSDYVLKAIEELEQYDKRELAALRMQKIFKFGAFAE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR17_GUITH
Sequence: MSIKERLGLVISDKMDKTVVVSIANRVTHKRYGKIVTKTKKYKVHDPNNNCQVGDLILINETRPLSKTKRWMFKEIKQKSLKLDKDTIGE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KITH_UREU1
Sequence: MAKAHAFSKKVGWIELITGPMFAGKTAELIRRLHRLEYADVKYLVFKPRIDTRSTQNIKSRTGTSLPSIEVENAPEILSYIMSDNFDNEIKVIGIDEVQFFDDRICEVANILAENGFVVIISGLDKNFKGEPFGPIAKLFAYADKITKLTAICNECGAEATHSLRKIDGKYANYDDEIVKIGCQEFYSAVCRHHHKVPNRPYLNANSEEFIRFFKNKKRNKNV
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WECA_SALTI
Sequence: MKLLTALSELISIFLFTTIFIFLARKVAIKIGLVDKPNFRKRHQGVIPLVGGISVFAGICFMFGLSDYYIPHLSLYLICAGVLVFVGAMDDRFDISVKIRAVVQAVIAVVMMVIAKLHLGSLGYIFGPWELVLGPFGYFLTLFAVWAAINAFNMVDGIDGLLGGLSSVSFAAMGLILWFDGQTSLAMWCFAMIAAILPYIMLNLGILGRRYKVFMGDAGSTLIGFTVIWLLLETTQGKTHSISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLVMRAGFTSRQAFVLITLAAAILAGVGVTAEYSHFVPEWVMLVLFLLAFFLYGYCIKRAWKVARFIKRVKRRLRRQRKNRPNLTK
What is the function of this protein?
Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
What are the official names of this protein?
Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase, Undecaprenyl-phosphate GlcNAc-1-phosphate transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. WecA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y6403_STRGG
Sequence: MLLLISPDGVEEALACATAAEHLDIVDVKKPDEGSLGANFPWVIREIRAAVPADKPVSATVGDVPYKPGTVAQAALGAAVSGATYIKVGLYGCATPDQAIDVMRGVVRAVKDFRADAFVVASGYADAHRIGCVNPLALPDIARRAGADAAMLDTAIKDGTRLFDHVPPEGCAEFVRLAHEAGLLAALAGSVKAADLATLTRIGTDIVGVRGAVCEGGDRDAGRIQPRLVAAFRAEMDRHARAFAAAPAAS
What is the function of this protein?
Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
What are the official names of this protein?
Putative (5-formylfuran-3-yl)methyl phosphate synthase, 4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthase, 4-HFC-P synthase.
What is the protein family that this protein belongs to?
Belongs to the MfnB family.
Protein: ITB1_MOUSE
Sequence: MNLQLVSWIGLISLICSVFGQTDKNRCLKANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARCDDLEALKKKGCQPSDIENPRGSQTIKKNKNVTNRSKGMAEKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTDRGEFFNELVGQQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSGNSSNVIQLIIDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITANKCPNKESETIKIKPLGFTEEVEVVLQFICKCNCQSHGIPASPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCRCRVCECYPNYTGSACDCSLDTGPCLASNGQICNGRGICECGACKCTDPKFQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKKDTCAQECSHFNLTKVESREKLPQPVQVDPVTHCKEKDIDDCWFYFTYSVNGNNEAIVHVVETPDCPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
What is the function of this protein?
Isoform 2 displaces isoform 1 in striated muscles.
What are the official names of this protein?
Integrin beta-1, Fibronectin receptor subunit beta, VLA-4 subunit beta.
What is the protein family that this protein belongs to?
Belongs to the integrin beta chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, focal adhesion. Cell surface. Note=Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions to fibrillar adhesions in an ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane, sarcolemma. Cell junction. Note=In cardiac muscle, isoform 2 is found in costameres and intercalated disks.
Protein: METK_CHLPM
Sequence: MSQSRYFFTSESVSEGHPDKVSDQISDAVLDSFISQDPNSRVACETFVTTGQVIVGGEVTTTGIVDIQKIARRVITEIGYTKGEYMFDANSCGVLSALHSQSADINRGVDRKEEIADEFDRVGAGDQGMMFGYACTETPELMPAAIQYAQRLVKLLAEIRKAGKIMTYLRPDSKSQVTLEYIDDKVARVDAVVVSTQHDPEPAGMSEAEFQAVIRKDIIENVINKVIPAELLDADTKFHINPTGRFEIGGPHGDTGLTGRKIIVDTYGGAAPHGGGAFSGKDPSKVDRSAAYASRHVAKNIVAAGLADKCTVQVSYAIGVARPVSIYINTHDTAKHGLTDEQIQEKAEKIFDLRPLAIIRRFNLDKPEGWSYQETAAYGHFGRENFPWEKTEKVEELKKAFNLA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_METPP
Sequence: MAVVKVKPTSPGRRAVVKVVHSHLHKGKPEASLLEPQIQNAGRNNNGHITIRHKGGGHKHHYRVVDFKRNKDGIPAKVERIEYDPNRTAHIALVCYADGERRYIIAPRGLEVGATILSGSEAPIKAGNTLPIRNIPVGSTMHCVELLAGKGAQIARSAGTSVTLLARESTYAQVRLRSGEVRRIHIECRATIGEVSNEEHNLRQYGKAGAIRWKGVRPTVRGVAMNPVDHPHGGGEGRTGEGQVPVSPWNTMTKGYRTRSNKRTQTFIVSRRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RFRNP_ALKEH
Sequence: MRRFVLDTSVFTNPHCAVQFGEDPLAGVQTFLHLARRCPAEFYMPLSVYDEFRRMRDLAEMAADFETDVWVRSPRRFSMTIPAEILYEFIHELRGRIDRGLRIAEEHTRQAGAATDMRPELIASLRERYREAMRKGLVDSREDVDAVLLAMELDAELVSADEGMRKLGNRMGVKLLTADYLRQVMENLGAGH
What is the function of this protein?
RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.
What are the official names of this protein?
RNA-free ribonuclease P, RNA-free RNase P, Protein-only RNase P.
What is the protein family that this protein belongs to?
Belongs to the HARP family.
Protein: DLGD_ECO81
Sequence: MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTEDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL
What is the function of this protein?
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
What are the official names of this protein?
2,3-diketo-L-gulonate reductase, 2,3-DKG reductase, 3-dehydro-L-gulonate 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.