PharMolix/UniProtQA huggingface dataset:
Protein: CPSF4_BOVIN
Sequence: MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPTKRTPQVIGVMQSQNSSAGSRGPRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ
What is the function of this protein?
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition.  CPSF4 binds RNA polymers with a preference for poly(U).
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, CPSF 30 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the CPSF4/YTH1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RBFA_GEOMG
Sequence: MYKRSDKVAEAIHELVSGLLVKGLKDPRIGFVTITGVKVSDDIRHATIYYTVMGSDEAKKSTLHGLNSSVGFIRKEVSKELRLRFAPELIFKYDESIEYGNRIDQLLKEIGSEEGGND
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCTP_DAVTA
Sequence: MLIYNDIISGDELISDSYDLVEVDGVAYEADCRKITIGGETFDTGANASAEGGDEEADDQKETKIDVVHAFQLQETNFDKKAYLGHLKSYMKKIKESMAASGASEDEVKEFEKGAQTFAKRVVGSFKDYEFLIGPSMDPDAMVVLLNYREDGVTPYVTLWKHGLKSTKV
What is the function of this protein?
Involved in protein synthesis.  Involved in microtubule stabilization.
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PCXA_MICAN
Sequence: MNLNRILQGVNQWLLQTPERSLDEAYHAALKIKEIEDKHFQGRKVANEFSNYGSSTNSYFIAEVKGYLQKIKVRLTEFKASRSIVNTFGPNQPTINNGVITVTTDVCLKKLQFIDSIIGKYQDNYWQEDIQDVPKSIQNRNFEQETAKNKTSRNRSFLAAGSIEDEEIIKSNKSQKATEKPGVLPRSFVNTFNRIKQEIDPQAEESEEAVLKKFRNSRYKTAISLKFILLLIIVPLLTQQLTKTFLITPLVNKYFQQQEQFIFINQDLEEEAFSELRRFEEALHFRGMIGLAPKLSNEEIEGEITKKAAVLSEEFRQRGLNAIANIFADICSLIAFGFVVAFSRREIEIVKSFLDGILYNLSDSAKAFLIILFTDIFVGFHSPHGWEVILEGLSRHFGLPENRQFNFLFIATFPVILDTVLKYWIFRYLNRISPSAVATYRNMNE
What is the function of this protein?
Involved in light-induced Na(+)-dependent proton extrusion.  Also seems to be involved in CO(2) transport.
What are the official names of this protein?
Proton extrusion protein PcxA.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIPB_BDEBA
Sequence: MADLIFQDWGLINYDEALKKQNDLVEKVHTEDLPGFLVFCTHPPVVTVGRATQAGDVFSWNGPVVEVTRGGRATYHGPSQLVVYPILNLAHVRKGRKDREINPYLKVFEDAIVDVLKTYGLTGIEGRSSAKSSFNRADADDTGVWVNDLKIASVGVGVRKWVAFHGAAINLTFDEKAFLGLRPCGFPSEVMVSLEQLTGAKVDVGEFKEKLKRRLLEVL
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CINAL_GEOUR
Sequence: MKIATLSIGDELIFGEVVDTNAAHISERLYSVGFKVQRQLTVGDNEQDIVEAIEMLAVKCDVVVVTGGLGPTVDDITARSAAKITGHELVLNEEALARLQRFSEKLGGNLHPSNEKQALMPANATLIPNPVGTACGFYLTHNGRFLFFLPGVPGEMACMLDETVIPFIVSRVKRRTFLQTKVFKVFGPSEAEVDALMDGVADEAAGVSVAFCVNFPEIQVKLRVEGHEEAVVAELLTRAGDKARQRLNGYVFAEDGETIDTVVASLFRETGFTLSLAESCTGGLVAKRITDIPGSSAYFLEGIVTYSNTAKTQLLDVPQRLLDEKGAVSSEVAVAMALGARKLSGSDIALAVTGIAGPDGGTAEKPVGTVYMALAGSNGCQAKRYTFHGDREEIRLITSFMAMDWLRKRLLSLRSAEVTD
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: XDH_CAUVN
Sequence: MSSAIYPSLKGKRVVITGGGSGIGAGLTAGFARQGAEVIFLDIADEDSRALEAELAGSPIPPVYKRCDLMNLEAIKAVFAEIGDVDVLVNNAGNDDRHKLADVTGAYWDERINVNLRHMLFCTQAVAPGMKKRGGGAVINFGSISWHLGLEDLVLYETAKAGIEGMTRALARELGPDDIRVTCVVPGNVKTKRQEKWYTPEGEAQIVAAQCLKGRIVPENVAALVLFLASDDASLCTGHEYWIDAGWR
What is the function of this protein?
Involved in the degradation of D-xylose, a major component of hemicelluloses such as xylan.  Catalyzes the initial reaction in the xylose utilization pathway by oxydizing D-xylose into D-xylonolactone.  Shows some activity toward L-arabinose, but little to none toward D-arabinose, L-xylose, D-ribose, D-galactose, D-glucose or D-glucose-6-phosphate.
What are the official names of this protein?
D-xylose 1-dehydrogenase, XDH.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PTH_FRATT
Sequence: MPKIKMIIGLGNIGKEYQDTRHNVGEWFIAKIAQDNNQSFSSNPKLNCNLAKVSIDYNNVVLVFPTTYMNNSGLAVSKVANFYKIAPAEILVVHDELDIDSGEIRLKKGGGHGGHNGLRSINQHLGTNDYLRLRIGIGHPGHKSKVANYVLSNPSIAQKKDIDSAIDNGICFLDDIINYKLEPVMQKLHTK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMB_PSESM
Sequence: MSQLEKIYGVHAVEALLRHHPKRVKHIWLAEGRNDPRVQTLVALASENRVTIGQAERREMDAWVEGVHQGVVADVSPSQVWGEAMLDELLDRSEGPPLLLVLDGVTDPHNLGACLRTADAAGALAVIVPKDKSATLTPAVRKVACGAAEVIPLVAVTNLARTLEKLQQRGLWVVGTAGEAEVELYQQDLTGPTIIIMGAEGKGMRRLTREHCDYLVRLPMAGSVSSLNVSVATGVCLFEALRQRSAKRKP
What is the function of this protein?
Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
What are the official names of this protein?
23S rRNA (guanosine-2'-O-)-methyltransferase RlmB, 23S rRNA (guanosine2251 2'-O)-methyltransferase, 23S rRNA Gm2251 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2612_MYCBO
Sequence: MLITGFPAGLLACNCYVLAERPGTDAVIVDPGQGAMGTLRRILDKNRLTPAAVLLTHGHIDHIWSAQKVSDTFGCPTYVHPADRFMLTDPIYGLGPRIAQLVAGAFFREPKQVVELDRDGDKIDLGGISVNIDHTPGHTRGSVVFRVLQATNNDKDIVFTGDTLFERAIGRTDLAGGSGRDLLRSIVDKLLVLDDSTVVLPGHGNSTTIGAERRFNPFLEGLSR
What are the official names of this protein?
Uncharacterized protein Mb2612c.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: OTC_ACTPJ
Sequence: MAFNLKNRHLLSLVNHTEREIKFLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAHVTYIDPTSSQIGHKESMKDTARVLGRMYDAIEYRGFKQSVVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCEKPLSQISYVYIGDARNNVGNSLLLIGAKLGMDVRICAPKALLPEDSLVEMCQKFAAESGARITVTDDIDTAVKGVDFVHTDVWVSMGEPLETWGERIDMLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKIGKQVAEKYPALANGIEVTEDVFESPANVAFEQAENRMHTIKAVMVASLA
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_PHOPR
Sequence: MKVAVIGAAGGIGQALALLLKNGLPAGSDLALYDIAPVTPGVAADLSHIPTPVSIKGYGGVDPTPALEGADVVLISAGVARKPGMDRSDLFNVNAGIIKSLAEKIAVVCPKACVGIITNPVNTTVAIAADVLKKAGVYDKRRLFGITTLDIIRSETFVAELKGKTPSDIQVPVIGGHSGVTILPLLSQVEGVEFSDEEIKALTPRIQNAGTEVVEAKAGGGSATLSMGQAAYRFGLSLVRALQGEQGIVECAYVEGDGKHARFFAQPVLLGKDGVEEVIDYGKLSTFEQEALNNMLDTLTSDITLGEEFAAK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: UPPP_LACLA
Sequence: MDFIRAIILGVIEGITEWLPISSTGHLIIADEFIRLNQSAAFKEMFDVVIQLGAILSVVVLYFHKLNPFNKLNPADKQKTPREIQLTWRLWLKVLIAALPAAIIGLPLNDWLDKHFYHFVPVAFMLIIYGVAFIVIERRWVPNHEFSVMNIDRLPYRAALYIGLFQVLSLLPGTSRSGATIVGALLVGVSREVAAEFTFFLGIPVMFGASFIKILHFFKNGNSLSFEQFGVLLVACIVAFGVSMVAIKFLTDYVKKHDFTFFGKYRIVLGIILLIYAMFRAFLG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPE_CAMJE
Sequence: MNDLINFEIVTPLGVIYQGEVKSVTLPGSEGEFGVLKGHAALVSSLKSGVIDIEKADLNHELIAIDAGHAKVDEDKICVLAKGAVWVCGSDESEIEKNLAQAKDLIKSMSSDNAALAATFSKLDNARMH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: URK_SHEPC
Sequence: MNSQQCVIIAIAGASASGKSLIAKTIFDELRRDLGTDQIGVINEDAYYRDQSHLSMDERVLTNYDHPKALDHQLLCTHLQLLKSGEAVDIPCYSYTEHTRTADTVTMTPKKVIILEGILLLTDPKLRELMDASVFMDTPLDICFLRRLTRDVAERGRTMESVISQYKKTVRPMFLQFIEPSKQYADIIVPRGGKNRIATDILKTRIQHLLAK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANF_CAVPO
Sequence: NPMYNVVSNADLVDFKNLLDHLEEKMPLEDEVVLPQVASEQNEEAGAVLSALPEVPSWPGEAGPAQREGGALGRGPWDSSDRSAPLKSKLRALLDAPRSLRRSSCFGGRMDRIGAQSSLGCNSFRYRR
What is the function of this protein?
May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation.  In vivo promotes natriuresis.  In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
What are the official names of this protein?
Natriuretic peptides A, Atrial natriuretic factor prohormone, preproANF, proANF, Atrial natriuretic peptide prohormone, preproANP, proANP, Atriopeptigen, Cardiodilatin, CDD, preproCDD-ANF.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
[Long-acting natriuretic peptide]: Secreted. Note=Detected in blood. SUBCELLULAR LOCATION: [Vessel dilator]: Secreted. Note=Detected in blood. SUBCELLULAR LOCATION: [Kaliuretic peptide]: Secreted. Note=Detected in blood. SUBCELLULAR LOCATION: [Urodilatin]: Secreted. Note=Detected in urine. Not detected in blood. Increased electrolytes, osmolality and intracellular cAMP levels increase peptide secretion/excretion. SUBCELLULAR LOCATION: [Atrial natriuretic peptide]: Secreted. Perikaryon. Cell projection. Note=Detected in blood. Detected in urine in one study. However, in another study, was not detected in urine. Detected in cytoplasmic bodies and neuronal processes of pyramidal neurons (layers II-VI) (By similarity). Increased secretion in response to the vasopressin AVP (By similarity). Likely to be secreted in response to an increase in atrial pressure or atrial stretch. In kidney cells, secretion increases in response to activated guanylyl cyclases and increased intracellular cAMP levels. Plasma levels increase 15 minutes after a high-salt meal, and decrease back to normal plasma levels 1 hr later (By similarity). SUBCELLULAR LOCATION: [Atriopeptin-3]: Secreted. Note=Detected in blood. Slight increase in secretion in response to the vasopressin AVP.
Protein: FLII_TREPA
Sequence: MEADLLCKYEVALRESEPVKYVGHVTAVRGLLIESRGPHAVVGELCRIVLRRQGRPLIAEVVGLAGSTVKLMSYTDTHGVEVGCAVVAEGAALSVPVGDALLGRVLNAFGKAIDGKGEIYAPLRSEVLRASSNPMERLPITRQMVTGVRVLDSLLAVGCGQRLGIFSGSGVGKSTLMGMIARNTDADVSVIALIGERGREVMDFVAHDLGPEGLKRSVIVSATSDESPLARVRGAYTATAIAEYFRDQGKQVLLLFDSLTRFAKAQREIGLASGELPATRGYTPGVFETLPKLLERAGSFSMGSVTAFYTVLVDGDDLDEPISDAVRGIVDGHIVLSRALAQRNHYPAIDVLQSVSRLAHRVLGADMKEAVRIVRRALAVYAEVEDLVRVGAYQQGSDAELDRAIAMRAELERFLTQGAQERVRFQDTVTSLSMLTGLSIAQPPSGV
What is the function of this protein?
Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.
What are the official names of this protein?
Flagellum-specific ATP synthase.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURJ_SALTY
Sequence: MQEFYARVWNTKEMNLLKSLAAVSSMTMFSRVLGFARDAIVARIFGAGMATDAFFVAFKLPNLLRRIFAEGAFSQAFVPILAEYKSKQGEEATRIFVAYVSGLLTLALAVVTVAGMLAAPWVIMVTAPGFADTADKFALTTQLLRITFPYILLISLASLVGAILNTWNRFSIPAFAPTFLNISMIGFALFAAPYFNPPVLALAWAVTVGGVLQLVYQLPYLKKIGMLVLPRINFRDTGAMRVVKQMGPAILGVSVSQISLIINTIFASFLASGSVSWMYYADRLMEFPSGVLGVALGTILLPSLSKSFASGNHDEYCRLMDWGLRLCFLLALPSAVALGILAKPLTVSLFQYGKFTAFDAAMTQRALIAYSVGLIGLIVVKVLAPGFYSRQDIKTPVKIAIVTLIMTQLMNLAFIGPLKHAGLSLSIGLAACLNASLLYWQLRKQNIFTPQPGWMWFLMRLIISVLVMAAVLFGVLHIMPEWSQGSMLWRLLRLMAVVIAGIAAYFAALAVLGFKVKEFVRRTA
What is the function of this protein?
Involved in peptidoglycan biosynthesis.  Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
What are the official names of this protein?
Probable lipid II flippase MurJ.
What is the protein family that this protein belongs to?
Belongs to the MurJ/MviN family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPD_DICNV
Sequence: MSQTETIARPYAKAVFEQAVETESVANWIDFLEIASTFVSNEAVKEHLASASFMENFLVWFEQFLVESRGEALSEQERNFLNVLNQQGRMAIVPEIATQFKQLYYSAQNVCKATVYTALALDEKQKKELQATIERNVHREVVLDVREEPALIAGVRIEYDGMVIDQSARGRLERFARMLDESRN
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATPA1_LEGPC
Sequence: MNWSNTPSFLEKQRQRLKRYQFQIKVSEQGRVVSVGDGIIWIKGLPGAAIDEILISEDECCIAMVFHLTEELVGAVMLVQTKKLKAGTPIFPLKRVLSIPVGDKLLGRVIDPLGHPLDGGEIPPHEEQGLLDRLSPHILHRDFVNRPLYTGNKMLDNLIPIGKGQRELLIGDNGLGKSALALDIVMNQKDKKVYCVYVLIGQKRSTVSSTIQLLKKANALDYTTVVVAQATALPGLLYLAPFAGCAIAEHWMKKGLDTLVVYDDLSAHANSYRELSLLLRRPPGREAFPADIFYLHSRLLERSTCLSPAMGGGSMTALPIIETKEGEMATYIPTNLISITDGQIFFDESLFSSGFLPAIDITKSVSRVGAKAQHPQIKKESGRMKLDYLQFLDLELFTRFGAKLDAKMQKQIQKGRVLREILKQERFSPLPIEFQLAWLIAYNEGFFDESNLEDIPQILKKIEKEIKQSNLSLGSPREQWKKAIKEWLMA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 1, ATP synthase F1 sector subunit alpha 1, F-ATPase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ARGJ_VITVI
Sequence: MFLCVPHYTSITFPQLNDGRKVLRFGSYQRRGFRILAMSSSVSEASNYITAAPIFLPDGPWKQIPGGVTAAKGFKAAGLYGGLRAKGEKPDLALVACDVDAISAGAFTTNVVAAAPVVYCKNALDMSKTARAVLINAGQANAATAKRPSNDYQGDAGYQDVIECANALAKLLQMRPEEVLIESTGVIGHRIKKDALLNSLPKLVSSLSSSTEGADSAAVAITTTDLVSKSVAIESEVGGTNIRVGGMAKGSGMIHPNMATMLGVRLCFLHVLFCKVVTTDALVASDVWRKMVQIAVNRSFNQITVDGDTSTNDTVIALASGLSGSTRISSLISHEAIQLQACLDAVMQGLAKSIAWDGEGATCLIEGSSLVNAATIRIWRYRGHMAMPTGPLRIISLHLWYWAINHVELCFAAVYGRDPNWGRIACAAGYAGIPFQPNKLHISLGEILLMEGGQPLPFDRAAASNYLKKAGETHGTVGIHISIGDGAGRGQAWGCDLSYDYVKINAEYTT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TOP3_STAAN
Sequence: MKSLILAEKPSVARDIADALQINQKRNGYFENNQYIVTWALGHLVTNATPEQYDKNLKEWRLEDLPIIPKYMKTVVIGKTSKQFKTVKALILDNKVKDIIIATDAGREGELVARLILDKVGNKKPIRRLWISSVTKKAIQQGFKNLKDGRQYNDLYYAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVNTRQQEINQFKPQQYFTLSLTVKGFDFQLESNQRYTNKETLEQMVNNLKNVDGKIKSVATKHKKSYPQSLYNLTDLQQDMYRRYKIGPKETLNTLQSLYERHKVVTYPRTDSNYLTTDMVDTMKERIQATMATTYKDQARPLMSKTFSSKMSIFNNQKVSDHHAIIPTEVRPVMSDLSNRELKLYDMIVERFLEALMPPHEYDAITVTLEVAGHTFVLKENVTTVLGFKSIRQGESITEMQQPFSEGDEVKISKTNIREHETTPPEYFNEGSLLKAMENPQNFIQLKDKKYAQTLKQTGGIGTVATRADIIDKLFNMNAIESRDGKIKVTSKGKQILELAPEELTSPLLTAQWEEKLLLIERGKYQAKTFINEMKDFTKDVVNGIKNSDRKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPSCKTKKNVQRKTNARCPNCKKKLTLFGKGKEAVYRCVCGHSETQAHMDQRMKSKSSGKVSRKEMKKYMNKNEGLDNNPFKDALKNLNL
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 3, DNA topoisomerase III.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: NMT_CRYNE
Sequence: MDSSDNKAATDEEIRRALKAADLMKILDGKMALGNKSGTKNLGEHKFWKTQPVPQITGSGASAPMEEGPIDDPKTPADVKQEPGVLPAGFEWSTIDINDEEQSKEVYVLLCENYVEDDDAMFRFNYSREFLLWALTAPGYLPDWHIGVRVQKTKKLVAFISGIKIDIRVRAKTFPAAEINFLCVHKKLRSKRLAPVLIKEVTRRVNLTNIWQAIYTAGVILPTPIGTCRYFHRNLNPPKLVDIGFSPLPRGSTIARLVQQYSVPSHPRIPGFREMKKEDVPQVGALLRRYLDRFDVAQAFKDDDEVEHWFLSGQGKEVGGRRVEQVVWAYVVEDPTTHRITDLISFYALPSTIMKHPKHNLLNAAYMFYYATDVIFPPPSSSAHSDADVNAGESSVAAVGTGGEDAKTKKKLETRLNALTADLLIIAKQAGFDVFNALTLLDNNMFLQEQKFGPGDGYLNYYLYNWNCAPIDGGQHSTTAKQGSKIGVVML
What is the function of this protein?
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
What are the official names of this protein?
Glycylpeptide N-tetradecanoyltransferase, Myristoyl-CoA:protein N-myristoyltransferase, NMT, Peptide N-myristoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE6_HPV18
Sequence: MARFEDPTRRPYKLPDLCTELNTSLQDIEITCVYCKTVLELTEVFEFAFKDLFVVYRDSIPHAACHKCIDFYSRIRELRHYSDSVYGDTLEKLTNTGLYNLLIRCLRCQKPLNPAEKLRHLNEKRRFHNIAGHYRGQCHSCCNRARQERLQRRRETQV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: ATPE_HALH5
Sequence: MPTLHVNVVTPDGKVYEGDVDMVSVKTVEGELGILPRHIPLVAPLTVGAVRLKKGSTVDLVAVSGGFVEVRPDQVTILAEAAELPSDIDVERARSAKERAEKRLQQAKQENIDFKRAELSLRRATNRLDVAGR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
Protein: LONP2_XENLA
Sequence: MASSGSIQIPRRLPLLLTHEGVLLPGSTMRTSVDTPGNMELVQNRLLRGTSLKSTIIGVVPNTSDPSSDREELPSLHRIGTAALAVQVVGSNWPKPHYTLLVTGLCRFQITEILKERPYPVAEVEQLDRLEQLSSKEEFKEALGDLSEQFYKYAVQLVDMLDNSVPAVAKLKRLLNNLPKELLPDVLTSIIRTTNEEKLQILDAVSLEERFKVTIPLLLRQIEGLKLLQKTRNPKQDDDKRIVAIRPPRKLGNISSKSFSLENTDDDDEDSDDIIILERKIKSSNMPEPALKVCVKEIKRLKKMPQSMPEYALTRNYLELMSELPWSKTTRDRLDIRAARILLDNDHYAMAKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSIAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKIVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEVLEVPGYSQEEKLEIAHRHLISKQLAQHGLTPEQIQIPQEATLEIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHREHKSEHLEAPEGEERKESVPEGSKSATINDTADFALPPEMPILIDHHALKDILGPPMYETEVFGRLNQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQLTNASGSFDLLDNTDIHLHFPAGAVTKDGPSAGVAIVTCLASLFSGRLVCSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKRVILPKRNETDLEEIPLNVRQDLEFVLAGSLDEVLNAAFDGGFSLKTTPDLLNSKL
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix.  Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
What are the official names of this protein?
Lon protease homolog 2, peroxisomal.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Peroxisome matrix.