PharMolix/UniProtQA huggingface dataset:
Protein: EFR3B_DANRE
Sequence: MTGVCGCCGALRPRYKRLVDNIFPEDPEDGLVKANMEKLTFYALSAPEKLDRIGAYLSERLSRDVARHRYGYVCIAMEALDQLLMACHCQSINLFVESFLKMVRKLLEADKPNLQILGTNSFVKFANIEEDTPSYHRSYDFFVSRFSEMCHSGYEDPDIRTKIRMAGIKGLQGVVRKTVNDELQANIWDPQHMDKIVPSLLFNLQSGEGTESRSPSPLQASEKEKESPAELTERCFRELLGRAAYGNIKNAVTPVLMHLDNHSLWEGKTFAVRCFKIIMYSIQSQHSHLVIQQLLGHLDANSKSSATVRAGIVEVLLEVAAIAASGSVGPTVLEVFNTLLRHLRLSVDYELTGSYDCTNIGTKIIKEHEERQLQEAVIRTIGSFANTLPTYQRSEVMLFIMGKVPIPGLHPTLPSIGSGPEGNRMIQVMLLKSLRQVTCGFQTTNMLTALPNSFLDPMLSFALLEDAEIRLLVLEILVSLIDRHDNLPKFSNISIISDISVLKLKVDKCSRQDNLFMKKHAQHLYRHIYLCSKEQSSVQPHFEKLYSLLALISMELANEEVVVDLIRVALALQDLALSSEEMLPVYNRCAIHALSSAYLNLISQLTTVPAFCQHVHEVIEMRQKEIPYLLPEDVFIENPKIPKTLEKLEGDVLFQQAKITEVLGGSGYNTERLATPYVPQFTDEDRLSKRKSIGETISLQVEVDSRNSPEKEERTPAEEITFETLKNAIVDSVGVEEQEKERRRQVVEKFQKAPFEEIAAHCGARATMLQSKLNQIFEITIRPPPSPSGTITSSYGQTQSRSVPVYEMKFPDLCVY
What is the function of this protein?
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.  The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis.  In the complex, efr3b probably acts as the membrane-anchoring component.
What are the official names of this protein?
Protein EFR3 homolog B.
What is the protein family that this protein belongs to?
Belongs to the EFR3 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Palmitoylation anchors the protein to the plasma membrane.
Protein: SYA_RENSM
Sequence: MKTQDIAQRWLDFFAAKGHTVVPSASLISADPSILFNIAGMVPFVPYLSGREKAPYDRATSVQKCIRTADIDEVGKTVRHGTFFQMCGNFSFGDYFKEGAITFAWELLTSSIADGGYGLDPSRLWATVYVDGTEKDEEARAIWRDKIGIPEERIQGTGKADNFWSTGQPGPGGPCSEIYYDLGAKYGQEGGPIVDETRYIEIWNLVFMQYQLSAVRSKTDFDIAGDLPNRNIDTGLGLERLAMILQGVENLYETDQVRPVLDAAAELAGKDYTSTVDPADPHHADDVRLRVVADHIRSALMLIADGVAPSNEGRGYVLRRLIRRAVRAMRLMGVEKPCLPALLPVSREAMKGFYPAVEEDFERISRIAYAEEKSFLRTIASGTARLDEAVTESKAKNQPLSGAEAFALHDTYGFPIDLTLEMAAEAGLAVDETGFRALMLEQRQRAQADSREKKSGHADLSAFNELLAQGQTVFTGYSELDGESAIRGLLSGGQPIAKASQGQEIELVLAETPFYAEAGGQAADTGLISGDGFVIEVLDVQRPVKDLSVHKAIVREGEVAIGASVRAAVDRERRHAAEQAHTGTHIVHAALHQILGPEALQRGSFNKAGYLRFDFAWGEGLSTATRSEIEEVANIAIRNNYSVQTTEMPIDEAKALGAMALFGENYGSRVRVVEIDGAWSRELCGGTHVDTTSRIGSLTLLGEQSVGYGNRRVEAFVGMDAFRHLAAERALVSELTEIMKVPSTQLADRIGATLAKLRATEKELDRLRKAQLTAAAGELTTKAQQVGKTRLLTHDVGQIGGADELRSLALDLRERLGSEAAVVALTGESNDRPMVLVATNEAARAAGVKAGALVKLAAGVLGGGGGGKDDVAQGGGSNVGQIPAALAAINQAVAAL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFB_PSEFS
Sequence: MTKSELIERIVTHQGLLSSKDVELAIKTMLEQMSQCLATGDRIEIRGFGSFSLHYRAPRVGRNPKTGQSVSLDGKFVPHFKPGKELRDRVNEDEEEGV
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: 3S1ED_LATSE
Sequence: MKTLLLTLVVVTIVCLDLGYTRRCFNQQSSEPQTNKSCPPGENSCYRKQWRDHRGTIIERGCGCPTVKPGIKLRCCESEDCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin OKI-Ed.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PSK1_YEAST
Sequence: MPYIGASNLSEHSFVNLKEKHAITHKGTSSSVASLQTPPSPDQENHIDNELENYDTSLSDVSTPNKKEGDEFEQSLRDTFASFRKTKPPPPLDFEQPRLPSTASSSVDSTVSSPLTDEDIKELEFLPNESTHSYSYNPLSPNSLAVRLRILKRSLEIIIQNPSMLLEPTPDDLPPLKEFAGRRSSLPRTSASANHLMNRNKSQIWNTTSATLNAFVNNTSSSSAASSALSNKKPGTPVFPNLDPTHSQTFHRANSLAYLPSILPEQDPLLKHNNSLFRGDYGNNISPERPSFRQPFKDQTSNLRNSSLLNERAYQEDETFLPHHGPSMDLLNEQRANLKSLLNLLNETLEKNTSERASDLHMISLFNLNKLMLGDPKKNNSERDKRTEKLKKILLDSLAEPFFEHYNFIGDNPIADTDELKEEIDEFTGSGDTTAITDIRPQQDYGRILRTFTSTKNSAPQAIFTCSQEDPWQFRAANDLACLVFGISQNAIRALTLMDLIHTDSRNFVLHKLLSTEGQEMVFTGEIIGIVQPETLSSSKVVWASFWAKRKNGLLVCVFEKVPCDYVDVLLNLDDFGAENIVDKCELLSDGPTLSSSSTLSLPKMASSPTGSKLEYSLERKILEKSYTKPTSTENRNGDENQLDGDSHSEPSLSSSPVRSKKSVKFANDIKDVKSISQSLAKLMDDVRNGVVFDPDDDLLPMPIKVCNHINETRYFTLNHLSYNIPCAVSSTVLEDELKLKIHSLPYQAGLFIVDSHTLDIVSSNKSILKNMFGYHFAELVGKSITEIIPSFPKFLQFINDKYPALDITLHKNKGLVLTEHFFRKIQAEIMGDRKSFYTSVGIDGLHRDGCEIKIDFQLRVMNSKVILLWVTHSRDVVFEEYNTNPSQLKMLKESELSLMSSASSSASSSKKSSSRISTGTLKDMSNLSTYEDLAHRTNKLKYEIGDDSRAHSQSTLSEQEQVPLENDKDSGEMMLADPEMKHKLELARIYSRDKSQFVKEGNFKVDENLIISKISLSPSTESLADSKSSGKGLSPLEEEKLIDENATENGLAGSPKDEDGIIMTNKRGNQPVSTFLRTPEKNIGAQKHVKKFSDFVSLQKMGEGAYGKVNLCIHKKNRYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMATLNKKPHENILRLLDFFEDDDYYYIETPVHGETGCIDLFDLIEFKTNMTEFEAKLIFKQVVAGIKHLHDQGIVHRDIKDENVIVDSKGFVKIIDFGSAAYVKSGPFDVFVGTIDYAAPEVLGGNPYEGQPQDIWAIGILLYTVVFKENPFYNIDEILEGDLKFNNAEEVSEDCIELIKSILNRCVPKRPTIDDINNDKWLVI
What is the function of this protein?
Serine/threonine-protein kinase involved in the control of sugar metabolism and translation.  Phosphorylates UGP1, which is required for normal glycogen and beta-(1,6)-glucan synthesis.  This phosphorylation shifts glucose partitioning toward cell wall glucan synthesis at the expense of glycogen synthesis.
What are the official names of this protein?
Serine/threonine-protein kinase PSK1, PAS kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTMAB_DANRE
Sequence: MADAKVDSATEISAKDLKEKKLIEEKENGKDATNGKENEENGEPEIDDEDDDEVDEDDEEGEGDEDEDEDDDDEDLGGGTKRGADDDEDEDEDDEDDVDPKKQKVN
What are the official names of this protein?
Prothymosin alpha-B.
What is the protein family that this protein belongs to?
Belongs to the pro/parathymosin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HVA22_HORVU
Sequence: MGKSWALLTHLHSVAGPSITLLYPLYASVCAMESPSKVDDEQWLAYWILYSFITLLEMVAEPVLYWIPVWYPVKLLFVAWLALPQFKGASFIYDKVVREQLRKYRGRNRNGDADHKVHILKAEADHGRVH
What are the official names of this protein?
Protein HVA22.
What is the protein family that this protein belongs to?
Belongs to the DP1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TOP6A_METJA
Sequence: MVKLPAISKKPREIAKQKIIELAKKMYEDLMKGKRPKITMPIRSLSNAMFDKEKGSFTLVGKEKARTLTVNQAKIFAQTTKMLEFAKQLLETDDFSTLREAYYVSKNWGEARFDDQQASNNVIEDLEAALGVLREHLGFIPEEDGSSVVGPLKIIEETPEGELVVDCTKLGTGAYNIPNDVTKLNLETDADFILAIETSGMFARLNAERFWDKHNCILVSLKGVPARATRRFIKRLHEEHDLPVLVFTDGDPYGYLNIYRTLKVGSGKAIHLADKLSIPAARLIGVTPQDIIDYDLPTHPLKEQDIKRIKDGLKNDDFVRSFPEWQKALKQMLDMGVRAEQQSLAKYGLKYVVNTYLPEKIKDESTWLP
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit A, Type II DNA topoisomerase VI subunit A.
What is the protein family that this protein belongs to?
Belongs to the TOP6A family.
Protein: MALT_SALCH
Sequence: MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALVTSPAGYGKTTLVSQWAAGKNELGWYSLDEGDNQQERFASYLIAAIQQATGGHCSTSEAMAQKRQYASLTSLFAQLFIELAQWHRPLYLVIDDYHLITNPVIHDAMRFFLRHQPENFTLVVLSRNLPQLGIANLRVRDQLLEIGSQQLAFNHQEAKQFFDRRLSSPIEAAESSRMCDDVAGWATALQLIALSARQNHTSAHHSARRLAGINASHLSDYLVDEVLDNVDVSTRHFLLKSAILRSMNDALIVRVTGEENGQMRLEEIERQGLFLQRMDDTGEWFSYHPSFGSFLRQRCQWELAAELSEIHRAAAESWMEQGFPSEAIHHALAAGDAQMLRDILLNHAWGLFNHSELALLEESLKALPWESLLENPRLVLLQAWLMQSQHRYSEVNTLLARAEQEIKGVMDGTLHAEFNALRAQVAINDGNPEEAERLAKLALDELPLAWFYSRIVATSVHGEVLHCKGDLSQSLSLMQQTEQMARHHDVWHYALWSLIQQSEIQFAQGFLQAAWETQERAFQLIKEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIAVLSTFQPQQQLQCLTLLVQCSLARGDLDNARSQLNRLENLLGNGRYHCDWISNADKVRVIYWQLTGDKKSAANWLRHTPKPAFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARSLRLMSDLNRNLLLLNQLYWQSGRKNDAQRVLLDALQLANRTGFISHFVIEGEAMAQQLRQLIQLNTLPEMEQHRAQRILREINQHHRHKFAHFDEGFVERLLNHPDVPELIRTSPLTQREWQVLGLIYSGYSNEQIAGELAVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYGV
What is the function of this protein?
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides.  Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.
What are the official names of this protein?
HTH-type transcriptional regulator MalT, ATP-dependent transcriptional activator MalT.
What is the protein family that this protein belongs to?
Belongs to the MalT family.
Protein: MSD6_AMAPH
Sequence: MSDINATRLPLILLAALGIPSDDADSTLTRGER
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:24613547).
What are the official names of this protein?
MSDIN-like toxin proprotein 6.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: SURE_NATPD
Sequence: MDVLLTNDDGIDAVGIRALYDALAEVADVTAVAPADDQSAVGRQLSRTVELHDHELGYAVEGTPADCVIAGLGALDLDPDIVVAGCNEGANLGEYVLGRSGTVSAAVEAAFFGVPAIAASVYFPAGDVTIEEFDPDKTDFAEASRAVRYLVDNAIGAGVFDAADYLNVNAPLPPETGHAPMEITEPSHVYEMDGERDGETVRIQDHIWERMAEGTIPDPPGTDRRAVVEGRVSVSPLTAPHPTTGHEGLAGLAEKYQ
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATB_METPE
Sequence: MKEYRTINKIAGPLVFIEKTEPIGYEELVNIVLYDGTIKRGQVLDTSDDLVVVQVFETTTGIGKDSGVRFTGETIKMPVGRDMLGRILSGSGKPIDGGPEIVPEKRLDITGAAINPYARASPSDFIETGISTIDGTNTLVRGQKLPIFSGAGLPHNNVALQIARQAKVPGSTEEFAVVFAAMGITQEEANYFMQDFERTGALERAVVFLNLADDPAVERIITPRLALTTAEYLAFELGMHVLVILTDMTNYCEALRQIGAAREEVPGRRGYPGYMYTDLASLYERAGIIKGQKGSVTQIPILTMPGDDITHPIADLTGYITEGQIVISRELHRKGIYPPINVLPSLSRLMNLGIGKGHTREDHKKVSDQMYAAYAEGNDLRGLVAIVGKDALSERDRTFLEFADLFENRFVRQGFDEDRTIADTLDLGWELLSSLPVEQLTRIDRDLIAKYHPQFKNAGAAQKR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: BATF_XENTR
Sequence: MQQEPDRNEQGYCSSPPSSNKQDSSDDTKKIQRREKNRIAAQKSRQRQTQKADSLHIESENLERLNSALRGEISGLREELKYLTCVLSTHQPVCVLGPTKPQAILPHVGSTRYQH
What is the function of this protein?
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells.
What are the official names of this protein?
Basic leucine zipper transcriptional factor ATF-like, B-cell-activating transcription factor, B-ATF.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells.
Protein: PKH1_YEAST
Sequence: MGNRSLTEADHALLSKPLVPTSAEHTQTQEYPRPFVDGSNSQSGSELQASPQGQFGEKALTSTNRFIPLANDDPGMQHEMGLDPSMRRRREEWAERGAAKIVKDVVDPATGELTKHVVKMGIKDFKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKYGSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAEYVSPELLNDNYTDSRCDIWAFGCILYQMLAGKPPFKAANEYLTFQKVMKIQYAFTAGFPQIVKDLVKKLLVRDPNDRLTIKQIKAHLFFHEVNFEDGSVWDDNPPEIQPYKINAEAMKPLQKVSESDTTVKMANLQLAGNGHADTPLQAPAATSQEHSVISMTAATAAFNKDYTSQPKLGSKSSTSVRSASNNTDREVIQKKVSKNRASVSSPSISTTSRGKDNRSRSSDAFWSRYLQNMDERVLLMKEVALSTRNLEDSPVGLENVALDYKNPLDIEPPTDSAGKFYKKMFLITNLGRALVFVKRRSLSMWEEQEFELQFELELNDVEKIRFISDQVLEIDGSRTIFIGCKERAVLMKLWKLIHNGMTAKPKVVSPKSDHKMFDKFILQKRQNTKKKNQAPPVPQSNRLINGLPDRCILKTPEEGALHTKRPTSLQTRSSSNYSKLLARSTQMRKNMTRTDEK
What is the function of this protein?
Activates YPK1 by phosphorylating of a threonine residue.
What are the official names of this protein?
Serine/threonine-protein kinase PKH1, 3-phosphoinositide-dependent protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
Protein: YHEU_SALDC
Sequence: MIIPWQGLAPDTLDNLIESFVLREGTDYGEHERSLEQKVADVKLQLQSGEAVLVWSELHETVNIMPKKQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: SYY_BEII9
Sequence: MSKDIPPASDFLAILTERGFLHQCSDPAGLDEKAKSGGLIAYIGFDCTAPSLHVGSLVQIMMLRWLQKTGGKPIVLMGGGTTRVGDPSGKDESRKILTLEEIEANKQGIKQVFSKFVHFGEGKTDALMADNAEWLTALHYIDFLRDVGRHFSVNRMLSMDSVKLRLERDQELSFLEFNYMCCQAYDFVELHKRYGCQLQMGGSDQWGNIVTGIDLGRRMGTAQLYALTSPLLTTASGAKMGKTAKGAVWLDEAMLPVFDYWQFWRNCEDRDVGRFLKLFTELPLDEIARLEALQDAEINEAKKILATEATAMVHGREAAERAADTARQTFEEGVVAASLPSVILQTNEIPAEGLGILAAFAKAGLVNSTSEARRQIKGGGLRLNDQPITDEKAVITIEAIEAGAKLSLGRKKHVLLRLADG
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNTB_ECOLU
Sequence: MEAIKGSDVNVPDAVFAWMLDGRGGVKPLENTDVIDEAHPCWLHLNYVHHDSAQWLATTPLLPNNVRDALAGESTRPRVSRLGEGTLITLRCINGSTDERPDQLVAMRVYMDGRLIVSTRQRKVLALDDVVSDLEEGTGPTDCGGWLVDVCDALTDHSSEFIEQLHDKIIDLEDNLLDQQIPPRGFLALLRKQLIVMRRYMAPQRDVYARLASERLPWMSDDQRRRMQDIADRLGRGLDEIDACIARTGVMADEIAQVMQENLARRTYTMSLMAMVFLPSTFLTGLFGVNLGGIPGGGWQFGFSIFCILLVVLIGGVALWLHRSKWL
What is the function of this protein?
Zinc transporter.  Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.
What are the official names of this protein?
Zinc transport protein ZntB.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PMP3_NEUCR
Sequence: MAFTASDICKIIVAVILPPLGVFFERGCGADLFINILLTILGYLPGIVHALYIILKY
What is the function of this protein?
Plays a role in the regulation of membrane potential.  Could mediate a proton leak (By similarity).
What are the official names of this protein?
Plasma membrane proteolipid 3.
What is the protein family that this protein belongs to?
Belongs to the UPF0057 (PMP3) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HV439_HUMAN
Sequence: MDLMCKKMKHLWFFLLLVAAPRWVLSQLQLQESGPGLVKPSETLSLTCTVSGGSISSSSYYWGWIRQPPGKGLEWIGSIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 4-39, Ig heavy chain V-II region WAH.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: CH601_VIBVY
Sequence: MAAKDVKFGNDARVKMLEGVNILADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFQNMGAQMVKQVASQANDVAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVAAAVEELKALSKDCSTSTEIEQVGTISANSDSSVGKIIAEAMEKVGRDGVITVEEGQALHDELDVVEGMQFDRGYLSPYFINNQESGSVELESPFILLVDKKISNIRELLPALEAVAKASRPLLIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTVISEEVGLELEKATLEDLGQAKRVSITKENTTIIDGVGEEAMIQGRVAQIRQQIEDATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGIVAGGGVALIRAASKIVDLQGDNEEQNVGIRVALRAMEAPLRQITKNAGDEESVVANNVRAGEGSYGYNAATGVYGDMLEMGILDPTKVTRSALQFAASVAGLMITTEAMVTDLPQKDSGMPDMGGMGGMGGMGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUTC_BACHK
Sequence: MTGLIQNRDSFLDNIAKELGRTRKTDGVERPVWKNNVNKETLKDYSQEELLEVFKNQCTNIHTTVVETTNDRLREDIQKVIVEYGGGPIMLSADERFDSYGLTSLFKEELPKQNVEVNVWDPEKKEENMRIAERANIGIAFSDYTLAESGTIVVQSHKGQGRSLHFLPTVYFAIIPRETLVPRITQAVQDMNTRVENGEEVASCINFITGPSNSADIEMNLVVGVHGPLKAVYFIV
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
What are the official names of this protein?
Lactate utilization protein C.
What is the protein family that this protein belongs to?
Belongs to the LutC/YkgG family.
Protein: CUTC_ECOL6
Sequence: MALLEICCYSMECALTAQQNGADRVELCAAPKEGGLTPSLGVLKSVRQRVTIPVHPIIRPRGGDFCYSDGEFAAILEDVRTVRELGFPGLVTGVLDVDGNVDMPRMEKIMAAAGPLAVTFHRAFDMCANPLNTLNNLTELGIARVLTSGQKSDALQGLSKIMELIAHRDAPIIMAGAGVRAENLHHFLDAGVLEVHSSAGAWQASPMRYRNQGLSMSSDAHADEYSRYVVDGAAVAEMKGIIERHQAK
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_BURA4
Sequence: MSGNTLGTLFTVTTFGESHGPAIGCVIDGCPPGMGLTEADIQVELDRRKPGTSRHVTQRQEADEVEILSGVFEGVTTGTPIALLIRNTDQRSKDYGNIVETFRPGHADYTYWQKYGIRDYRGGGRSSARLTAPIVGAGAVAKKWLRERFGVEVRGYMSCLGDIDVPFVDWSHVRENPFFSPNAAIVPELEAYMDALRKDGDSIGARIDVVASGVPVGWGEPVFDRLDADIAKAMMSINAVKGVEIGAGFDSVAQRGSVHGDELTPAGFIGNHAGGVLGGISTGQDITVSIAIKPTSSIRTPRRSITKAGDEATVETFGRHDPCVGIRATPIAESMLALVLIDHALRHRAQCGDVETSTPKISGSAT
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: NDKA_MOUSE
Sequence: MANSERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFLQASEDLLKEHYTDLKDRPFFTGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFQPEELVEYKSCAQNWIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.  Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities.  Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression.  Required for neural development including neural patterning and cell fate determination.  During GZMA-mediated cell death, works in concert with TREX1.  NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity).
What are the official names of this protein?
Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Metastasis inhibition factor NM23, NDPK-A, Tumor metastatic process-associated protein, nm23-M1.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PYRH_LACGA
Sequence: MSQIKYKRIILKVSGEALAGEKGTGINPEVIKHLAEEIKSVHDMGVEIGIVCGGGNMWRGETGANLGMERAQADYMGMLATIMNGLALQDGLENLGVPTRVQTSIEMRQIAEPYIRRKAMRHLEKGRVVIFGGGTGNPYFSTDTTAALRAAEIDADVILMAKNGVDGVYSADPKVDPNAKKYSELTQLDLISKNLKVMDSTASSLSMDNNIPLVVFNVNKPGNIKKVVMGENIGTVIKGDK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_XANOM
Sequence: MPAKSRSARLTHLDDAGLPTMVDVSGKAITARSATAESRVRFPAAVAAQLRANGLRSAKGGIVETAVIAGTMAVKRTHELIPFCHPLPIDACRFEIDWAGEQVLDIRCTVRCVHRTGVEMEALTGASVAALTVYDMCKALSHSMSIGPTRLVSKRGGKRDIGAAQ
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.