PharMolix/UniProtQA huggingface dataset:
Protein: RRF_RHOPS
Sequence: MQSEKFDINEVKRRMHGASQALQHELGGLRTGRASASMLEPVQVDAYGTHMPLNQVATVSVPEPRLLSVQVWDKSMVKAVEKAIVDSNLGLSPATEGQVLRLRIPELNQDRRKELVKVAHKYAEAARVAVRHVRRDGLDIIKKLEKAHEISEDDQKRLDHEVQKATDATISEIDQLLANKEKEILTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAA_HALWD
Sequence: MLEDEFGREVSGVRVSLTDRCNFDCVYCHNEGLGDTRGPMDPQDDEMSTDDVVRFLEVVSQFDIGKVKFTGGEPMLRDDLTEIIRRTPSSMEVSMTTNGTFLPGRAGALREAGLERVNVSQDALDPDEFAEITKSGAYDRVLEGVEAAVDAGLAPVKLNMVVFEHTAEYVEDMVNHVSENAGLQLQLIEYMPELTGHPEWNIDIQRVHDWLADIADRVETREMHDRNRYFVGDGMVEIVDPVENPTFCANCHRVRVTHEGYLKGCLNRNDDLRSMGEMTREEIRETFRETVANRVPYYGEYLIKENDEWVLNDKYLDAPTTHS
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
Probable GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: CYOE_COLP3
Sequence: MPSVINTGHHHFSISNIFANWRAYYDITKPKVVALLVLTALVGMSLSVPGALPWQRLIPAMLGIGLLSSAAAAINHIVDEKIDTVMGRTHNRPLPAGKISVTNAIVFATSIALLGFIILYALVNPLTAFLTLAGLVGYSFVYTMYLKRATPQNITIGGLAGAIPPLLGWTAMTNEVVPNALLLVLIIFTWTPPHFWALAIHRKNDYAKVNIPMLPVTHGVSFTKTQILLYTVLLFVVCLLPYLVGMSNWLYLIGACSLNLIFFGYAWQLKFNAKEGTAMATFKFSIIHLMLLFIILLLDHYWLPMG
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YFCD_SHIFL
Sequence: MEQRRLASTEWVDIVNEENEVIAQASREQMRAQCLRHRATYIVVHDGMGKILVQRRTETKDFLPGMLDATAGGVVQADEQLLESARREAEEELGIAGVPFAEHGQFYFEDKNCRVWGALFSCVSHGPFALQEDEVSGVCWLTPEEITARCDEFTPDSLKALALWMKRNAKNEAVETETAE
What are the official names of this protein?
Uncharacterized Nudix hydrolase YfcD.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: MINA1_CAEEL
Sequence: MDDSTPYPVPQELYIPQKMKAFMAEPQGCALVAALEGQFQCSIVVINDHLSVISSADGVAVDINQIEKILRDVWRKRDVQIMIREAALNASCTHICHTLLPRAYCAVVLFFSSDLQRRSRCTDIIIDQFTGKVTMFGTEQAVNKAREMMIECLTEHFGLLEMNIPPTQRTTRMGYTNSYNPEIRTHLPPNSFLNSVFPMGEPNAILTSTPPTTSIMDEPLLSASLEKHLLFPSDFSVPPPRLSPVQELPLTPPKTCVVEKIKQWIPTTEVGKILGNRAAVKKHIERQFNCVITVHTEVQSSFGATPVEIVAQNKEQCQEARNAVMSLMQSHQDKPASNPPDSGFSTPGSPFTSDSSSTTPEKRGNSRQYHRGSFRDQPKVMLALTPRKLSPSD
What is the function of this protein?
RNA-binding protein which binds to its own mRNA and target mRNAs to negatively regulate gene expression to modulate apoptosis and differentiation in the germline (PubMed:30728462).  Negatively regulates the expression of the argonaute protein wago-4, and may thus play a role in RNA-mediated gene silencing (RNAi) in the germline (PubMed:30728462).
What are the official names of this protein?
Messenger RNA-binding inhibitor of apoptosis 1.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.
Protein: RL3_LEGPC
Sequence: MMIGLLGRKIGMTRVFTPEGVSVPVSVVEVQPNRVSQVKTAANDGYSAVQLTGGTKKSSKVSKPVAGHFAKAQIDAGDMQVEFRIDSEDAFTPGQVISVADVFTAGQYVDVSGLTKGKGFAGTVKRHNFRTQDASHGNSRSHRVPGSIGQNQTPGRVFKGKKMAGHMGNARCTIQSLELVKVDSERNLLLIKGAIPGAPGSRVEIKPAVKKQARGE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: SYH_RHIME
Sequence: MNEKQKKTQKLRARLPRGFVDRSAADIRAVDEMIAKIREVYERYGFDPVETPLFEYTDALGKFLPDSDRPNEGVFSLTDDDDQWLSLRYDLTAPLARHVAENFNEIQLPYRTYRAGYVFRNEKPGPGRFRQFMQFDADTVGAAGVQADAEMCMMMADTMEALGIARGDYVIRVNNRKVLDGVLEAIGLGGVEQTNTRLTVLRAIDKLDKFGPEGVRLLLGEGRKDESGDFTKGAGLNEEQIGKILFFVGITDYARSADELAALVAGTARGAEGVNELNTIRGLVLSAGYEADRIKIDPSVVRGLEYYTGPVFEAELQFAVTNEKGEKVVFGSVGGGGRYDGLVSRFMGQPVPATGFSIGVSRLMTALKNLGKLGAEQVTAPVVVCVMDRDIESMGRYQRFVQDLRHAGIRAEMYQGNKKNFGDQLKYADRRGSPIAVIQGGDERASGVVQIKDLIEGKRLSGEIEDNVAWREARVAQVSVPEGELVAKVRQILAEQAEDRKRAG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_SALAR
Sequence: MAKNIQAIRGMNDYLPGETAIWQRIESTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFHQLGAEVFGLQGPDIDAELIMLTARWWRALGIAEHVSLELNSIGSLEARANYRDALVAFLEQHQETLDEDCKRRMYTNPLRVLDSKNPDVQALLNDAPALGDYLDDDSREHFAGLCKLLDAAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFIASPVVDIYLVAAGTETQSAAMTLAERLRDEMPDVKLITNHGGGNFKKQFARADKWGARIALVLGESEVANGTVVVKDLRSGEQTAVAQDSVAAHLRTLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDGT_ECO27
Sequence: MQIKRSIEKIPGGMMLVPLFLGALCHTFSPGAGKYFGSFTNGMITGTVPILAVWFFCMGASIKLSATGTVLRKSGTLVVTKIAVAWVVAAIASRIIPEHGVEVGFFAGLSTLALVAAMDMTNGGLYASIMQQYGTKEEAGAFVLMSLESGPLMTMIILGTAGIASFEPHVFVGAVLPFLVGFALGNLDPELREFFSKAVQTLIPFFAFALGNTIDLTVIAQTGLLGILLGVAVIIVTGIPLIIADKLIGGGDGTAGIAASSSAGAAVATPVLIAEMVPAFKPMAPAATSLVATAVIVTSILVPILTSIWSRKVKARAAKIEILGTVK
What is the function of this protein?
Catalyzes the proton-dependent uptake of 2-keto-3-deoxygluconate (KDG) into the cell.
What are the official names of this protein?
2-keto-3-deoxygluconate permease, KDG permease.
What is the protein family that this protein belongs to?
Belongs to the KdgT transporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GPDA_RHIE6
Sequence: MSERIAVIGSGAFGTALAAVIALAGRSPVILVGRNPSLVADLKAERLHDAVLPGIALPESLEFSAEAEAIAGASIVLFAMPSQAQADAARQYGPYLSKDAVVVTCAKGIERTTGNLLTDMLERELPDHPVAVLSGPGFAADIAKGLPTAMAIAAADMETAERLAQAISGRTFRLYASDDRIGVQLGGALKNVLAIACGIVEGRGIGESARAALIARGLAEMSRFVVAKGGQADTVRGLSGLGDLVLTGTSHQSRNLRFGIALGRGEKADPLQGALVEGALAASVASRLAAALSISMPITDAVSAIIDGRLEIADAIEQLMTRPITTE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_AZOVI
Sequence: MAKQKKHPQGNIAQNKKALHDYFIEQKFEAGLALSGWEVKSLRAGKAQLVDSYVLLKDGEAWLMGSHITPLKTASTHVIADPTRTRKLLLHKRELGRLFGSVQQKGYACVALSLYWKKHLIKCEIALAKGKKEYDKRDTEKARDSDREIQRAIRSKGKED
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SYE2_GRABC
Sequence: MVHVRFAPSPTGYLHVGNARIAVANALFALRYSGKFTLRLDDTDLERSRDEYAEAIAQDLRWMGIEWADTFRQRDNMDRYEAAADALKASGRLYPCFESEEELRYKRELRLKQGRAPVYDRAMLKMTPEQRAQAEANGKRPYWRFLLSDRTVGWRDGVLGPRQVKLQAISDPVVIRADGTPLYTFTSVVDDIATGVTHIIRGEDHISNSGVQTDLFEALGKVAPALAHLPLLMDADGGKLSKRIDSLTLRSLARDGIEPVALVSYLARLGSSRDPQPLTLAELAQEFDLDAFSASSARFDGSQLAALNRRTLQTMPFSAVQDRLPQGATEAFWEAVRGNLDMLAEARLWWDVVAGSIVPPVLTDEDNALLKQALPLLPQEPWDTTTWSVWTRAVKEASDRSGRALFRPLRLALTGEEHGPELAALLPLMGAERVRTRLTLTSGAMAG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_MYCSS
Sequence: MKTGIHPDYVETTVQCGCGNTFTTRSTKKTGNIVVEVCSQCHPFYTGKQKILDSGGRVARFEKRYGKRGANKAANTDSADK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: YOR2_NEIGO
Sequence: RQSLRLLSDGNDSXDIRHLSRLLDNLGSVDQQFRQLRHSDSPAENDRMGDTRIAALETGSFKNTWQAIRPQLNLESGVFRHAVRLSLVVAAACTIVEALNLNLGYWILLTRLFVCQPNYTATKSRVYQRIAGTVLGVIVGSLVPYFTPSVETKLWIVIAGTTLFFMTRTYKYSFSTFFITIQALTSLSLAGLDVYAAMPVRIIDTIIGASLAWAAVSYLWPDWKYLTLERTAALAVCSSGTYLQKIAERLKTGETGDDIEYRITRRRAHEHTAALSSTLSDMSSEPAKFADTCNPALPCSKPATALTGYISALGHTAAKCTKNAAPTLPHSSTLPPNTPPTSSNTCPTWDPTTFRRHWIHCAANSAPSAPAAAEHKATSSSNSSNSSPGSSNPTTAPTDKFRTGSPKTQPEKISAFW
What are the official names of this protein?
Uncharacterized protein ORF2.
What is the protein family that this protein belongs to?
Belongs to the YccS/YhfK family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RODZ_ECO8A
Sequence: MNTEATHDQNEALTTGARLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPADLASTFLRGYIRSYARLVHIPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMTFTWLVLFVVIGLSGAWWWQDHKAQQEEITTMADQSSAELSSNSEQGQSVPLNTSTTTDPATTSTPPASVDTTATNTQTPAVTAPAPAVDPQQNAVVSPSQANVDTAATPAPTATTTPDGAAPLPTDQAGVTTPAADPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEQSPAQ
What is the function of this protein?
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
What are the official names of this protein?
Cytoskeleton protein RodZ.
What is the protein family that this protein belongs to?
Belongs to the RodZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Forms helical filaments along the long axis of the cell.
Protein: PEND_PENCR
Sequence: MTNSLLNNGDMVQGVELPDADQQFWWDSLAPILSRMLQCSKYSVQSQANILSFFKDFIVPSYGPRPSIDGEFFWKSYVTYNHTPGQVSFNFHKNKCTVRLSNVPTAPLAGTASDPFNQKGVVQTIKHIQKALPGMDMTIFDYFSEAFLVADEDTVGLDARKPVPQYNQLVVASMLGYDFEPVPRVKVYFNPRWKALQMNIENHDLIWTAINNLGSPIKSYKRTLDLLQECGNPRQPGGWIFQPEFISFDMGENMSNTARLKLYGFTTKTCWSHIESIYTLDRRLDDAETQRGLAVLKRLWHLALSIPEDHDENQDLPPCPHLTAGVIYNYELRENSAKPEAKIYIPVRFYGSGDGKVIEGLVDFFKSEGWDELATSYQRDFVSVFSTPDGKMVGEHHDISFSYKNDHPYVTAYYRPELIRPMERHIV
What is the function of this protein?
Indole diterpene prenyltransferase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:26213965).  The geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (Probable).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase penC then forms 3-geranylgeranylindole (3-GGI) (Probable).  Epoxidation by the FAD-dependent monooxygenase penM leads to a epoxidized-GGI that is substrate of the terpene cyclase penB for cyclization to yield paspaline (Probable).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase penP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase penQ (PubMed:26213965).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase PC-15 which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase penD (Probable).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase PC-16 and the P. simplicissimum ptmI-ortholog not yet identified in P. crustosum, leads to the production of the prenylated form of penijanthine (Probable).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase PC-22 (Probable).  A series of oxidation steps involving 4 cytochrome P450 monooxygenases (PC-21, PC-05, PC-23, PC-20) and a FAD-dependent monooxygenase (PC-14) are required for the transformation of PC-M4 to penitrems A and E.  Synthesis of these final products is proposed to proceed via penitrems D and C (PC-21, PC-05, PC-14) and penitrems B and F (PC-21, PC-05, PC-14, PC-23) (Probable).
What are the official names of this protein?
Indole diterpene prenyltransferase penD, Penitrem biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: TWF2B_XENLA
Sequence: MAHQTGIHATPELKEFFAKARNGSVRLIKVIIEEEQLVLGSHKELKHAWDQDYDAFVLQLLDESQPCYILYRLDSQNAQGYEWIFLSWSPDHSPVRLKMLYAATRATVKKEFGGGHIKDEIFGTLKEDVALSGYKKHVSSCAAPAPLTAAERELQAIKINEVKTEISVESKQQTLQGLSFPLRPQAEEAILLLKQKKINYIQLRLDLEKETVDLVHTKHTEIQDLPGRIPQDTARYHFFLYKHSHEGDHLESVVFIYSMPGYKCSIKERMLYSSCKNRLLDSVEQDFLMEIAKKIEIEDGAELTDEFLYDEVHPKQHAFKQAFAKPKGPAGKRGQKRLIKGPGENGEDS
What is the function of this protein?
Actin-binding protein involved in motile and morphological processes.  Inhibits actin polymerization, likely by sequestering G-actin (By similarity).
What are the official names of this protein?
Twinfilin-2-B.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization.
Protein: ZFP82_HUMAN
Sequence: MALRSVMFSDVSIDFSPEEWEYLDLEQKDLYRDVMLENYSNLVSLGCFISKPDVISSLEQGKEPWKVVRKGRRQYPDLETKYETKKLSLENDIYEINLSQWKIMERIENHGLKGLILKNDWESTGKIEGQERPQEGYFSSVKMPSEKVSSYQKRTSVTPHQRLHFVDKPYECKECGKAFRVRQQLTFHHRIHTGEKPYECKECGMAFRQTAHLTRHQRLHSGEKLYECKECGEAFICGADLRVHQKMHIGEKPYECKECGKAFRVRGQLTLHQRIHTGEKPYVCKECGKAFRQYAHLTRHQKLNSADRLYECKECGKAFLCGSGLRVHHKLHTGEKPYECKECGKAFRVRQQLTLHQRIHTGEKPYECKECGKTFSRGYHLILHHRIHTGEKPYECKECWKAFSRYSQLISHQSIHIGVKPYDCKECGKAFRLLSQLTQHQSIHIGEKPYKCKECGKAFRLRQKLTLHQSIHTGEKPFECKECRKAFRLNSSLIQHLRIHSGEKPYECKECKKAFRQHSHLTHHLKIHNVKI
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 82 homolog, Zfp-82, Zinc finger protein 545.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TDRD9_MOUSE
Sequence: MLRKLTVDQINDWFTIGKTVTNVELLGLPPAFPAEAPREEVQRSEEVPNEDPTAQAQVPVKATAPARPASTSGRSLSQRSSEMEYINKYRQLEEQELDIYGQDQPPSGPGLRSPLAKLSNVACIPETTYKYPDLPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCKQFADYFAVPVQNKMNPAYVFEVEGKPHAIEEYYLNDLGHIYHSGLPYRLEEPVITKDVYEVAVSLIQMFDDLDMKESGNKTWSGAQFVSERSSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDECLIIAAALSLKNFFTMPFRQHLDGYRNKVHFSGSSRSDCLALVEAFRAWQACRQRGELRRPKDELDWGRLNYIQIKRIREVAELYEELKNRISQFNMFVGPHHPVLDQEYPYKQRFILQVVLAGAFYPNYFTFGQPDEEMAVRELAGKDPKTTVVLKHIPPYGFLYYKQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVNLAVKMSQLKVSLELSVHAAEEIEGKVQGGSVSKLRNTRVNVDFQKQTVDPMQVSFNTLDRPRTVADLLLTIDVTEVVEVGHFWGYRIDERNAELLKQLTAEINRLELVPLPIHPHPDLVCLAPFTDYNKESYFRAQILYVSGNSAEVFFVDYGNRSHVDLDLLREIPCQFLELPFQALEFKICKMRPSAKSLICGEHWSGGAHGRFAALVGGCPLLVKVFSIVHSVLHVDVYRYSGAQDAVNVRDVLIREGYAELAEESYESKQSYEVLKGFFAKSVDTMPDGSVSSPLKDDEKHLLRILLESFASNRLGAPNCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVVISDSPADLHQRMLVAASLSVNETGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDREGKCYTGVLCGLGWNSATEAPILPEHDIELAFDVRLNVEDIVEINILRAAINKLVCDGPNGSKYLGPERIAQLQENARQKLLGLFCRLKPREKITPQWHEKPYEWNQVDPRLIMEQAEPEGSPGKSTSLYQLHTPVVLSP
What is the function of this protein?
ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20059948, PubMed:28633017).  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20059948, PubMed:28633017).  Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4 (PubMed:28633017).
What are the official names of this protein?
ATP-dependent RNA helicase TDRD9, Tudor domain-containing protein 9.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies.
Protein: PPT1_HUMAN
Sequence: MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEKKIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAHIIPFLG
What is the function of this protein?
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation.  Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748).
What are the official names of this protein?
Palmitoyl-protein thioesterase 1, PPT-1, Palmitoyl-protein hydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the palmitoyl-protein thioesterase family.
What are the subcellular locations of this protein?
Lysosome. Secreted.
Protein: ISPH_WOLPM
Sequence: MEIILAEPRGFCAGVKRAVDILAITLEKYKNERQVYVLHEIVHNKYIVEDFKKQGVVFVSSIEEIEDNEGILIFSAHGVSKNIEDEAKRKGIQVIDATCPLVNKVHKEAKRYENSGKELILIGHENHPEVKGIRGRVNNPITLVQTLQDVYDLKVKDPDNLSYVTQTTLSIDDTRDIIAALKLRFPGITGPDLKDICYATQNRQNAVKKLAEIVDMVLVVGSKNSSNSNRLLDLCTARGKRAYLIDNYSCVNKSWFQGVEKIGITAGASAPDILVDELIDYLKVNLSVKISVMPGGITENVQFKIPNLV
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: LEU3_DEBHA
Sequence: MSQPELKKSKVDISKTITVLPGDHVGEEVCNEAIKVLQAIEDATPYRNIKFNLQKHLIGGAAIDATGTPLPDESLEAAKNSDAVLLGAVGGPKWGTGSVRPEQGLLKIRKELNLYANLRPCNFASDSLLELSPLKSEIVKGTDFTVVRELVGGIYFGERQEQAESEDKQTAWDTEKYSTEEVTRITRMAAFMALQHNPPLPIWSLDKANVLASSRLWRTTVDKVMSEEFPQLTIQHQLIDSAAMILVQSPTKLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNSAFGLYEPCHGSAPDLTENKVNPVATILSVAMMLRLSLDCVPEAEALEKAVGQVLDSGIRTGDLRGSSSTKEVGDAIAEAVKKVLNQSV
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, IMDH, Beta-IPM dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATD_STRPS
Sequence: MVRLNVKPTRMELNNLKERLKTAERGHKLLKDKRDELMRRFISLIRENNRLRKEVESYLIDNLKSFAVAKSLKNSLMVEELFSIPSKEIELFIEKENIMSVTVPRMHMNITSQNENSEYSYLSSNSEMDDVFATMNSLIDKLLRLAEVEKTCQLMADEIEKTRRRVNGLEYSIIPNLSETIHYIELKLEEAERANLVRIMKVK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: PGLRB_ASPFU
Sequence: MHFFQSSLVAATMGAALVAAAPAADLETRGSCTFTSTSALKSGKASCSTITLQNIAVPAGETLDLTGLKTGTTVVFDGTTTFGYKEWEGPLISASGTSITIKQNPGAKIDCDGARWWDGKGGNGGKKKPKFFSAHKLNKSNITGLKVYNTPVHGFSIQSDHLTIKDVLLDNSAGTKLGHNTDAFDVGSSTYITIDGATVYNQDDCLAVNSGEHITFTNGYCNGGHGLSIGSVGGRSNNVVNDVTISNSQVINSQNGARIKTVYGATGSVTGVKFQDISLKGITKYGIVVQQDYENGKPTGKPTNGVKVSDITFEKVTGTVTSSATDIYILCGSGSCTNWTWSGNSVTGGKKSSSCKNVPAGASC
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.  Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall (By similarity).
What are the official names of this protein?
Probable endopolygalacturonase B, Pectinase B, Polygalacturonase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: BIOB_ANOFW
Sequence: MDWLLLANRVLDGADITDDEALAILNCPDDELLLLLQGAYRIRKTYYGNKVKLNMIMNAKSGLCPENCGYCSQSSISTAPIPTYKMVNKETILQGAKRAYEAKIGTYCIVASGRGPSDKEIDIVVSAVKEIKETYGLKVCACLGILKPEQALRLKEAGVDRYNHNINTSKEHHPHITTSHTYDDRVRTVETVKEAGMSPCSGVIIGMKETKQDVIAMARSLKALDADSIPVNFLHAIDGTPLEGTKELNPRYCLKVLALFRYINPTKEIRISGGREVNLRSLQPLGLYAANSIFVGDYLTTAGQEKHADFQMLEDLGFDIDFAPASYAR
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: KR14_ICHVA
Sequence: MAEKLIPSCRGQWFLPARVLREGFLRARPVAVDGGFKLTIGPLTVATRVWDWVYVHYNENATDWLRGMNPPFWEEPCDVLDFLPGVACVNEATFLTLKKKYGSYLHLFVPLRHTRGNIFFGFSPLSATGMAVLKIKTFHGGTQAPDRPGVPMEVYAWETAHFLDAAPKLIEWEVSGTRENRKSAQMVTFSECGLYGSMEGYFYRERATVDICATILADLTGKLLALIRKGIYHGDLKSENIIMMSRSGPGKLIDFEHSHGPGETMTSFWYPDRTFFWNPIGTEAYAPPERSRGRGRNAGVPGIVFQIGLIALNIMVERMERVFVNHTWIKGDGYRAHVLKVIKARGTLDLRGGARTLARVDELIGLVARCLERDPAMRPSLETLVDEFSKI
What are the official names of this protein?
Protein kinase ORF14.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.