PharMolix/UniProtQA huggingface dataset:
Protein: RSMA_ECOL5
Sequence: MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAAKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMRAENISVAQYCQMANYLAENAPLQES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_PHATC
Sequence: MINIRPDEISSIIREQIEKYDQDVKVDNIGTVLQVGDGIARVYGLDQVMSGELLEFEDKTIGIALNLENDNVGVVLMGTGRQILEGSTVKATGRIAQIPVGDEFLGRVVSPLGVAIDGKGEIVTSDSRLLEAMAPGIISRKSVCEPLQTGITSIDAMIPIGRGQRELIIGDRQTGKTSIAVDTIINQQTEDVICVYVGVGQKASTIAQVVNVLEEKNAMSYTIVVASSANDPATLQYIAPYAGAALAEYFMYKGKATLIVYDDLTKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDKLGGGSMTALPIIETQASDVSAYIPTNVISITDGQIFLSNDLFNSGIRPAINVGISVSRVGSAAQTKAMKKVAGKLKLELAQFAELEAFSQFASDLDEATQKQLARGTRLREVLKQPQNSPLSVAQQVALIYTGINGYLDDLPVSNVKSYCASLMTYLTTSKKPYTEIVRTTNQFTEEAESSLKEAILESKEAFSKTN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: LMP1_EBVB9
Sequence: MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALMLIIIILIIFIFRRDLLCPLGALCILLLMITLLLIALWNLHGQALFLGIVLFIFGCLLVLGIWIYLLEMLWRLGATIWQLLAFFLAFFLDLILLIIALYLQQNWWTLLVDLLWLLLFLAILIWMYYHGQRHSDEHHHDDSLPHPQQATDDSGHESDSNSNEGRHHLLVSGAGDGPPLCSQNLGAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPHDPLPQDPDNTDDNGPQDPDNTDDNGPHDPLPHSPSDSAGNDGGPPQLTEEVENKGGDQGPPLMTDGGGGHSHDSGHGGGDPHLPTLLLGSSGSGGDDDDPHGPVQLSYYD
What is the function of this protein?
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation.  Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family.  LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells.  Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins.  For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses.  Inhibits also host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2.  Induces SUMO expression during viral latency thereby dysregulating the host sumoylation processes (PubMed:30659232).
What are the official names of this protein?
Latent membrane protein 1, LMP-1, Protein p63.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae LMP-1 family.
What are the subcellular locations of this protein?
Host cell membrane; Multi-pass membrane protein.
Protein: SAT_RIFPS
Sequence: MIKPVGSDELKPLFVYDPEEHHKLSHEAESLPSVVISSQGPRVSSMMGAGYFSPAGFMNVADAMGAAEKMTLSDGSSSCSVLCLLENTDAIGDAKRIALRDPNVEGNPVLAVMDIEAIEEVSDEQMAVMTDKVYRTTDMDHIGVKTFNSQGRVAVSGPIQVLNFSYFQADFPDTFRTAVEIRNEIKEHGWSKVVAFQTRNPMHRAHEELCRMPMESLDADGVVVHMLLGKLKKGDIPAPVRDAAIRTMAEVYFPPNTVMVTGYGFDMLYAGPREAVLHAYFRQNMGATHFIIGREPPAWVTTTVPSTPRPSSMTKCQRAPWRSRSSCRPHGLLQEAEQDCDDARRAGSHQGRLRTALRHQGREMLGQGIAPPPEFSRPEVAKILMDLLPVHQQLILIWFSGKTRPGVGRWRVFLCAAGALWPEAVAVANMEKRSSTG
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: FADI_ECOBW
Sequence: MGQVLPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVGELLARSEIPAEVIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKKLARVLVDVNKARTMSQRLKLFSRLRLRDLMPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAHRSHQRAAQAWSDGKLKEEVMTAFIPPYKQPLVEDNNIRGNSSLADYAKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLVPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMSDLTLIDMHEAFAAQTLANIQLLGSERFAREALGRAHATGEVDDSKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVTACAAGGLGAAMVLEAE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POL_EIAVC
Sequence: TAWTFLKAMQKCSKKREARGSREAPETNFPDTTEESAQQICCTRDSSDSKSVPRSERNKKGIQCQGEGSSRGSQPGQFVGVTYNLEKRPTTIVLINDTPLNVLLDTGADTSVLTTAHYNRLKYRGRKYQGTGIIGVGGNVETFSTPVTIKKKGRHIKTRMLVADIPVTILGRDILQDLGAKLVLAQLSKEIKFRKIELKEGTMGPKIPQWPLTKEKLEGAKEIVQRLLSEGKISEASDNNPYNSPIFVIKKRSGKWRLLQDLRELNKTVQVGTEISRGLPHPGGLIKCKHMTVLDIGDAYFTIPLDPEFRPYTAFTIPSINHQEPDKRYVWNCLPQGFVLSPYIYQKTLQEILQPFRERYPEVQLYQYMDDLFVGSNGSKKQHKELIIELRAILLEKGFETPDDKLQEVPPYSWLGYQLCPENWKVQKMQLDMVKNPTLNDVQKLMGNITWMSSGVPGLTVKHIAATTKGCLELNQKVIWTEEAQKELEENNEKIKNAQGLQYYNPEEEMLCEVEITKNYEATYVIKQSQGILWAGKKIMKANKGWSTVKNLMLLLQHVATESITRVGKCPTFKVPFTKEQVMWEMQKGWYYSWLPEIVYTHQVVHDDWRMKLVEEPTSGITIYTDGGKQNGEGIAAYVTSNGRTKQKRLGPVTHQVAERMAIQMALEDTRDKQVNIVTDSYYCWKNITEGLGLEGPQSPWWPIIQNIREKEIVYFAWVPGHKGICGNQLADEAAKIKEEIMLAYQGTQIKEKRDEDAGFDLCVPYDIMIPVSDTKIIPTDVKIQVPPNSFGWVTGKSSMAKQGLLINGGIIDEGYTGEIQVICTNIGKSNIKLIEGQKFAQLIILQHHSNSRQPWDENKISQRGDKGFGSTGVFWVENIQEAQDEHENWHTSPKILARNYKIPLTVAKQITQECPHCTKQGSGPAGCVMRSPNHWQADCTHLDNKIILTFVESNSGYIHATLLSKENALCTSLAILEWARLFSPKSLHTDNGTNFVAEPVVNLLKFLKIAHTTGIPYHPESQGIVERANRTLKEKIQSHRDNTQTLEAALQLALITCNKGRESMGGQTPWEVFITNQAQVIHEKLLLQQAQSSKKFCFYKIPGEHDWKGPTRVLWKGDGAVVVNDEGKGIIAVPLTRTKLLIKPN
What is the function of this protein?
During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme.  RNase H activity is associated with the reverse transcriptase.
What are the official names of this protein?
Pol polyprotein.
What is the protein family that this protein belongs to?
Belongs to the retroviral Pol polyprotein family.
Protein: CHEP_PARID
Sequence: ILGLLKGISALLS
What are the official names of this protein?
Chemotactic peptide.
What are the subcellular locations of this protein?
Secreted.
Protein: PLSX_PELPD
Sequence: MRIAVDAMGGDNAPTIEVEGAVAACREFGIPITLVGDQERLRKELELHHCSGLDIDIFHASEVVGMHDSASDAIRRKKNSSVRLAFELVKEGKACAAVSAGNSGATMAAGMFVLKRIKGIDRPAIAQVFPTLKGKTLVLDIGGTVDCKPIHLAQFAIMGEVYARYVMGIADPVVGLLSNGEEESKGNELTRETNTLLRKTSLNYAGYIEGRDIFKGQIDVVVCDGFVGNIVLKLSEGLADAAGRMLKQEILKSWVSKLGYLFVRGAFKRFRRIVDYAEYGGAPLLGINGVGMICHGGSSVKAIKNAIRLAEEYARNGVAEHVVEKLSENHIESLQRDNAKLQAVGE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ST4A1_MOUSE
Sequence: MAESEAETPGTPGEFESKYFEFHGVRLPPFCRGKMEDIADFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKELTSPRLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHCHQLVDQCCNAEALPVGRGRVGLWKDIFTVSMNEKFDLVYKQKMGKCDLTFDFYL
What is the function of this protein?
Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol.  May have a role in the metabolism of drugs and neurotransmitters in the CNS.
What are the official names of this protein?
Sulfotransferase 4A1, ST4A1, Brain sulfotransferase-like protein, mBR-STL, Nervous system sulfotransferase, NST.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KC1D_XENTR
Sequence: MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAAEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGANRAAEDAERERREREERLRHPRNPAARGLPSTASGRLRGTQEVTPSTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQETSRMSTSQIPSRVASSGLPSTVHR
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  Central component of the circadian clock.  May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation.  Participates in wnt signaling (By similarity).
What are the official names of this protein?
Casein kinase I isoform delta, CKI-delta, CKId, Tau-protein kinase CSNK1D.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MCRD_METTH
Sequence: MDVQIFPHRLLGADTTEKLLNRLEDISGVKRMVIHGQRLPPEDHPDRRIISVKGHEFELQVKTGRVLLEIEDEDTIADIKRVCEDLLPFGYDVTPGKYIRTQKTVTDEIKYGEDLDKVPEELIGLTDQNARLSERATIIKRKKEH
What are the official names of this protein?
Methyl-coenzyme M reductase I operon protein D.
Protein: FETJ_GLOBL
Sequence: MHFLVALVLLGQIIGSTLSSQVRGDLECDDREAKEWADQAVRYINEHKLHEYKQALNVIKNIVVVPWNGDLVAVFLKLNLLETECHVLDPTPVEKCTIRPQQNHAVEMDCDAKIMFDVETFKQDVFVKCHSTPDSVEDVRRNCPKCPILLSPRDPHVVDSVEYVLNKHNEQLSGHVYEVLEISRGQHKYEPEAFYVEFAIVEVNCTAQEAHDDHHHCHPNTAGEDHIAFCKATVFRSHASLEKPKHENFESDCVILDVKEGHAHSHLIEHHIGKYSTSPGQNSTVECVAECPVAFVNKEVPTDISDRHTTPVKGCPGKILHFQL
What is the function of this protein?
Suppress hemorrhage induced by metalloproteinases from the same venom (brevilysin-H3, -H4, -H6) and from habu venom (weak inhibition of the metalloproteinases HR2A).  The non-hemorrhagic brevilysin-H2 is strongly inhibited by jMSF, whereas the brevilysin-L6 is not inhibited.  Does not inhibit serine and cysteine proteases such as trypsin, chymotrypsin, thermolysin, and papain.  The inhibition may occur by formation of a non-covalent complex between this protein and the proteinases at their metalloproteinase domains.
What are the official names of this protein?
Antihemorrhagic factor jMSF, Japanese mamushi serum factor.
What is the protein family that this protein belongs to?
Belongs to the fetuin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NCAP_PUUMK
Sequence: MSDLTDIQEEITRHEQQLVVARQKLKDAERAVEVYPDDVIKNTLQARQQTVSALEDKLADYKRRMADAVSRKKMDTKPTDPTGIEPDDHLKERSSLRYGNVLDVNAIDIEEPSGQTADWYTIGVYVIGFTIPIILKALYMLSTRGRQTVKENKGTRIRFKDDTSFEDINGIRRPKHLYVSMPTAQSTMKAEELTPGRFRTIVCGLFPTQIQVRNIMSPVMGVIGFSFFVKDWPEKIREFMEKECPFIKPEVKPGTPAQEVEFLKRNRVYFMTRQDVLDKNHVADIDKLIDYAASGDPTSPDDIKSPNAPWVFACAPDRSPPTCIYVAGMAELGAFFSILQDMRNTIMASKTVGTAEEKLKRKSSFYQSYLRRTQSMGIQLDQRIILLYMLEWGKEMVDHFHLGDDMDPELRGLAQSLIDQKVKEISNQEPLKI
What is the function of this protein?
Encapsidates the genome protecting it from nucleases (Probable).  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication (Probable).  The nucleocapsid has a left-handed helical structure (By similarity).  As a trimer, specifically binds and acts as a chaperone to unwind the panhandle structure formed by the viral RNA (vRNA) termini (By similarity).  Involved in the transcription and replication initiation of vRNA by mediating primer annealing (By similarity).  Plays a role in cap snatching by sequestering capped RNAs in P bodies for use by the viral RdRp during transcription initiation (By similarity).  Substitutes for the cellular cap-binding complex (eIF4F) to preferentially facilitate the translation of capped mRNAs (By similarity).  Initiates the translation by specifically binding to the cap and 40S ribosomal subunit (By similarity).  Prevents the viral glycoprotein N (Gn) from autophagy-dependent breakdown maybe by blocking autophagosome formation (By similarity).  Inhibits host EIF2AK2/PKR dimerization to prevent PKR-induced translational shutdown in cells and thus the activation of the antiviral state (By similarity).  Also displays sequence-unspecific DNA endonuclease activity (By similarity).
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the hantavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm, host perinuclear region. Host Golgi apparatus, host cis-Golgi network. Note=Internal protein of virus particle.
Protein: RECR_STRP8
Sequence: MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSNEDVNDFAKNLLAAKRELTYCSICGNLTDDDPCHICTDTSRDQTTILVVEDAKDVSAMEKIQEYHGYYHVLHGLISPMNGVGPDDINLKSLITRLMDGKVSEVIVATNATADGEATSMYISRVLKPAGIKVTRLARGLAVGSDIEYADEVTLLRAIENRTEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RS18_BACC4
Sequence: MAGRKGGRAKRRKVCFFTANGITRIDYKDVDLLKRFVSERGKILPRRVTGTSAKYQRKLTVAIKRARQMALLPYVGE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: CWC24_ASHGO
Sequence: MFRKRNVKGSQQKKAALRVVEDDVECLATPPVVPAKKRKIRELDDTSRSAVRASGFGRDHVSAGTQEAVARATDDAPDRRAESSGARTAVGSNVRTRVVMDYQPDVCKDYRQTGFCGYGDSCKFLHSRDDFRAGWRLNEEWKVGQTEARDLDSIPFRCVLCRGHYRAPVRTRCGHYFCGGCFARRVRETRQCAVCGADTQGVAQSAARLRELLAAGAGAGDSPDDTPAEEEPRSPGEPAAGEERRGAESG
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC24.
What is the protein family that this protein belongs to?
Belongs to the CWC24 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DLP2_CAMJJ
Sequence: MQINLLNDFIKAYENTYSVSFDDSFKGRIQELCKELNEPFMHASYALENELKELVFSLDKNVNIAIIGQFSSGKSSLLNLILGRDCLPTGVVPVTFKPTFLRYAKEYFLRVEFEDGSDIITNIEKLAFYTDQRNEVKQAKSLHIFAPIPLLEKITLVDTPGLNANENDTLTTLDELKNIHGAIWLSLIDNAGKKSEEDAIKANLELLGENSICVLNQKDKLSAEELDNVLNYAKSVFLKYFNELIAISCKEAKDEQSYEKSNFQSLLDFLTQLDTTVLKEKFVKRKILNLCEILEDENQLFVGIFDRLLNQFQSYEKHLLLAYENFLKEIEILNHQILEQLKSISERISSEIFASVKEKDAYFYKESKGFLKKDLYTRYDYKAPYISSDDAFLAMFYNSDVMSKEFKKIKNELYKSFEEIKMKLKDFINILEREILLFKAEFSNIQKDHIFQSDKNFSELRAFCNASDEYFLKDFKELLFKSILELDLFFEKLNLKAFTNYENATKLSLAFFSRKINESRVLYELDSSEFVLFYPKKSEIYERVLNELNVYEFETLLINKPILTKIAKNFLEQSQNLIQEKNKFLDLKKAELQKRRAQILNVRESIKED
What is the function of this protein?
The heterotetrameric DLP1(2)-DLP2(2) complex tethers liposomes and may mediate their fusion.  Initial binding is probably mediated by DLP1, while DLP2 couples DLP1 subunits and increases the effective reach of the complex up to 45 nm.  The role of the nucleotide is unknown.  This subunit alone very weakly binds to liposomes; GTP, GDP, GMPPCP and GMPPNP do not change heterotetramer binding.  Tetramerization is required for GTPase activity, suggesting the GTPase domains (dynamin-type G) from DLP1 and DLP2 must dimerize to reconstitute the GTPase active site.
What are the official names of this protein?
Dynamin-like protein 2, DLP2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ETXA_STAAE
Sequence: MKKTAFILLLFIALTWTTSPLVNGSEKSEEINEKDLRKKSELQGAALGNLKQIYYYNEKAKTENKESHDQFLQHTILFKGFFTNHSWYNDLLVDFDSKDIVDKYKGKKVDLYGAYYGYQCAGGTPNKTACMYGGVTLHDNNRLTEEKKVPINLWLDGKQNTVPLETVKTNKKNVTVQELDLQARRYLQEKYNLYNSDVFDGKVQRGLIVFHTSTEPSVNYDLFGAQGQNSNTLLRIYRDNKTINSENMHIDIYLYTS
What is the function of this protein?
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules.  In turn, waves of cellular activation, cytokine production, and migration into the lung tissue and airways occur via alphabeta T-cells.  Causes also the intoxication staphylococcal food poisoning syndrome.  The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
What are the official names of this protein?
Enterotoxin type A.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TGT_ACIB3
Sequence: MKFEKLGQSGRARRGRLTLEHGVVETPVFMPVGTYGTVKGMLPRDIEDIQAQIILGNTFHLYLRPGLEVIKQHGGLHDFIKWNKPILTDSGGFQVFSLGAMRKIKEEGVTFRSPIDGSKVFLSPEISMEIQHVLNSDIVMIFDECTPYPATHEEAQKSLQLSLRWAKRCKAHHHDELKNKNALFGIIQGGMYEDLRDESLNGLLEIGFDGYAIGGLSVGEPKEEMIKVLDYLPNKMPHDKPRYLMGVGKPEDIVEAVRRGVDMFDCVMPTRNARNGHYFVTDGLVRIRNSKYRHDQGPLDPHCDCYTCKNFTRAYLFHLEKCGEMLASMLGTIHNLRYYQRLTEGMRDALDNGTFDEFVQDFYARRGLEVPPCPVDE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SCX3_TITBA
Sequence: KKDGYPVEADNCAFVCFGYDNAYCDKLCGDKKADSGYCYWVHILCYCYGLPDNEPTKTNGKC
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity).  Is lethal to mice (PubMed:8611151).
What are the official names of this protein?
Toxin Tb3, P-Mice-alpha* NaTx3.3, TbTx IV-5.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPF_MYCVP
Sequence: MKFAKGHGTQNDFVLLPDLTADLALTPAAVAALCDRRQGLGADGVLRVTTAGAARAAGVFDRLPEGVVEGDWYMDYRNADGSIAQMCGNGVRVFAHYLRASGLESRDEFVVGSLAGPRPVVLNALAGVGADVTVEMGKANQLGVGAATVGGRQFNGLAVDVGNPHLACVDAAMSSRELAALDVAAPVVFDAAQFPDGVNVEVLTAPEDGAVSMRVHERGVGETRSCGTGTVAAAVAALAHQGSQTGSLTVRIPGGEVVVTITDANSYLRGPSVLVAHGDLADEWWAAQG
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_POLAQ
Sequence: MEKFTVYKGLVAPLNRENVDTDAIIPKQFLKSIKKTGFGQNLFDEWRYLDHGEPGQDCSTRPINPDFVLNQPRYKGAGILLARKNFGCGSSREHAPWALDQFGFRAVIAPSFADIFYNNCFKNGVLPIVLTEMQVDHLFNETQAFNGYQLTIDLEGQKVITPDGTAYSFDVAPFRKHCLLYGLDDIGLTLQHADKIKAYEAERILKMPWLATQLP
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: SECB_PSEA7
Sequence: MTEQATNGAADEQQPQFSLQRIYLRDLSFESPKSPEIFRQEWNPSISLDLNTRQKQLDGDFYEVVLTVSVTVKNGEDTTAFIAEVQQAGIFLIKNLDPSSMSHTLGAFCPNILFPYAREALDNLVVRGSFPALMLSPVNFDALYAQEIARMQASGEIPTPSVQ
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMM18_BOVIN
Sequence: MPSAFSVSRFPVSIPAVITQTDWTEPWLVGLAGFHVLCLLLTCFSSQRYRLQVGHFLCLVTLVYCAEYINEVAAMNWRLFSKHQYFDSRGMFISLVFSAPLLLNALVIVVLWVRKTLVVMTDLRSLREQRRARARPKEE
What is the function of this protein?
Transcription repressor.  Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats.  Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (By similarity).
What are the official names of this protein?
Transmembrane protein 18.
What is the protein family that this protein belongs to?
Belongs to the TMEM18 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus membrane; Multi-pass membrane protein.
Protein: PUR6_HUMAN
Sequence: MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL
What is the function of this protein?
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.
What are the official names of this protein?
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, PAICS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.