PharMolix/UniProtQA huggingface dataset:
Protein: GPA1_NEUCR
Sequence: MGCGMSTEEKEGKARNEEIENQLKRDRMQQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFKEIIFSNTVQSMRVILEAMESLELPLADQRVEYHVQTIFMQPAQIEGDVLPPEVGNAIEALWRDAGVQSCFKRSREYQLNDSARYYFDNIARIAAPDYMPNDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFIKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGDDYAAACDYILNRFVSLNQHETKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRLCGLI
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-1 subunit, GP1-alpha.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(q) subfamily.
Protein: ATPE_VESOH
Sequence: MSTIHVDVVSATESLYSGEVLCVFAPASTGELGIYPKHTALLSILKPGEVRIETDKGIESIYVSGGIVEVQPDVVTIFSDTAIRANDLDEFKVLEAKQRAQDEMDNSIDTQDISATQAALSESMAQLQMINKMRGKKC
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DPO42_AGRFC
Sequence: MRKIIHVDMDAFYASVEQRDNPELRGRPVAVGSAAARGVVAAASYEAREFGVRSAMPSVTAARRCPDLIFVPPRFDVYKAVSQQIRAIFAEYTRLIEPLSLDEAYLDVTENLKGMEIATEIASEIRERIKQITGLNASAGISYNKFLAKMASDLNKPNGQAVITPKNGPAFVEQLAVKKFHGVGPATAEKMHRFGIETGADLKSKSLQFLAEHFGKSGAYFYGIARGIDERQVRPDRIRKSVGAEDTFSVDINDLDLATAELRPLAEKVWHHCEAQRVSGKTVTVKVKYSDFTQATRSRTSALPVNGIQEILEAASALLATVYPFRRSVRLLGVTLSSLTNDQEAEDEEQPQLDLAL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity).
What are the official names of this protein?
DNA polymerase IV 2, Pol IV 2.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWEET_BRADU
Sequence: MDPFLIKLIGFAAATCTTVAYAPQFIKVLKTRSARDISLGMFLVMVLGLALWLIYGLLSGDAPLIASNAVTMLLAGGILVMKLRYG
What is the function of this protein?
Mediates sucrose transmembrane transport down a concentration gradient.
What are the official names of this protein?
Sugar transporter SemiSWEET.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: INS_ANGRO
Sequence: ASTQHLCGSHLVEALYLVCGSNGFFFNPKDGIVEQCCHKPCSIFDLQNYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACTX_TAKRU
Sequence: MSDYDETALVCDNGSGLVKAGFAGDDTPRAVFHAIVGRPRHQDDMDDMGKKGYYVGDEAQSKRDILSLKHPIERGIITNWDDMEKIWHHTFYNELCVAPEEHPTLLTEAPLNPKANREKMTQIMLETFNMPAMYVSIQAVLSLYASGRTTGIVLDSGEGVTHAVPIAEGYALPPAIMRLNLAGRDLTDYLMKILNERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKRYELPDGQVITIGNERFCCPETLFQPSFMGMESAGIHEITHSSIMKCDIEIRKDLYANNVLTGGATLFPGIADRMQKEITALAPSTMKIQIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYEEIGPSIIHCKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, alpha anomalous.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: VNPB_PSEAU
Sequence: SDSKIGDGCFGLPLDHIGSVSGLGCNRPVQNRPKQIPGGS
What is the function of this protein?
Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity.  Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity).
What are the official names of this protein?
Natriuretic peptide PaNP-b.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RRAAH_BURMS
Sequence: MMFATTDLCDAHEDRLAAGTLRVLEPVFRPFGGVRRFAGPAATLKLFEDNSLVRTALEQDGAGRVLVVDGGGSLRCALVGGNLGKLAEKNGWAGIVVNGCVRDSDELAECRVGVLALAAHPRKSDKRGAGVSDAPVDVRGTRIVPGDWIYADADGVLVSDDALLE
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: DPOD4_BOVIN
Sequence: MGRKRLITDSYPVVKRREGSAGHSKGELAPDLGEEPLPLSVDEEELELLRQFDLAWQYGPCTGITRLQRWHRAEQMGLKPPPEVHQVLQSHPGDPRFQCSLWHFYPL
What is the function of this protein?
As a component of the tetrameric DNA polymerase delta 4 complex (Pol-delta4), plays a role in high fidelity genome replication and repair.  Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity.  Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system.  Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb.  Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites.  Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival.
What are the official names of this protein?
DNA polymerase delta subunit 4, DNA polymerase delta subunit p12.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase delta subunit 4 family.
What are the subcellular locations of this protein?
Nucleus. Note=Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation.
Protein: SUB12_ARTGP
Sequence: MSIFKLMVIYFTLFWVVNAAQLLDLDSHGVIPGAYIVVMKNGVSSHQFSSHVRWLKRAHRRNLAKRVAPFTEGLSSTWDIAGWQAYSGSFDKDTIQEILNHENVEFVEPNREMKAASTIKQENITWGLARISHMENFSHDYVSTYGEGENLTFYGIDSGIDIHQSDFTGRARWGINVADHIDIDCIGHGTHTAGTVAGQSFGILKKASIVSVKVLDCYGHGDTTKYINGLNWAINDAKKRGLLGKSVMNISLGTGRSRAVNEATVRAQEAGIFISVAAGNNAINAEFLSPGSAPELCTVAASTRNDTRAYFSNYGALIDLFAPGEYIRSTLPHNRTGIMSGTSMAAPHVCGIGGLIMAAEGLAPEQVCRRLKELANPAIKYAGFNTTDKLLYNGSGA
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 12.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y072_AFV1Y
Sequence: MGERVRIKLYVPYQDIRDNCKRRTDFYSDFEISVDDIQYISFSELIRLVKANPEYIEQLKKVLTEWDKGESG
What are the official names of this protein?
Uncharacterized protein ORF72.
Protein: RL13A_SPIOL
Sequence: VSGSGIMAKRVVVDA
What are the official names of this protein?
60S ribosomal protein L13a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: NCBP1_DROMO
Sequence: MSRRRAHDTEDESFDHRRNKRRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLEADLGTFRLKILRILSDCAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKTFKESLKLCRWDAARYSLRFLADLVNCHVISATSLLQLLDTMIDVSNEDTVPQVRRDWFVFAVLSTLPWVGRDLYEKKESALESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQDNWAEKHIPRPYLVFDSILCEALQHNLPQITPPPHHASFEYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLIEEHLHHIIETHHHERKDCAAQLLNFPFKHKIPLEYCIVEVIFAELFHMPTPRYLDICYGSILIELCKLQPGTLPQVLAQATEILFMRIDSMNTSCFDRFVNWFSYHLSNFKFTWSWDEWDSCLLLDAEHPRPKFIQEVLQKCLRLSYHQRITEMMPTTYAKLIPAPPVPNYKYTNEEAANLPGITVALQLVGAIRQKCTPEEVVNILKEIPNTGYSGEEMSDGSFNALKIDVFVQTLLNLGSKSFSHSFAAISKFHAVFRALAETEEAQICILHNIFELWSSHQQMMVVLIDKLLKLQIVDCSAVATWIFSKEMTGEFTKMYLWEILHLTIKKMNKHVIKLNTELSEAKEKLSKADSSSSDTDEDTPHKRKKPITHADKPSEEVVERMEEKLEAANVNQKRLFLIVFQRFIMILSEHLLRSDTDGRDPDTDWYRWTIGRLQQVFLMHHEQVQKYSSTLETLLFTSDLDSHILEVFQQFVALRA
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi).  The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing.  Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 1, 80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the NCBP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TKT1_VIBCH
Sequence: MSSRKQLANAIRALSMDGVQKANSGHPGAPMGMADIAEVLWRSHLNHNPQNPNWADRDRFVLSNGHGSMLIYSLLHLSGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAIAEKALAAQFNKPGHDIVDHFTYVFMGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFEAYGWHVIPAVDGHDADAINAAIEAAKAETSRPTLICTKTIIGFGSPNKAGSHDCHGAPLGNDEIKAAREFLGWEHAPFEIPADIYAAWDAKQAGASKEAAWNEKFAAYAKAYPAEAAEYKRRVAGELPANWEAATSEIIANLQANPANIASRKASQNALEAFGKLLPEFMGGSADLAPSNLTMWSGSKSLTAEDASGNYIHYGVREFGMTAIINGIALHGGFVPYGATFLMFMEYARNAMRMAALMKVQNIQVYTHDSIGLGEDGPTHQPVEQIASLRMTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQPRSAEQVANIAKGGYILKDCAGQPELILIATGSEVELAVAAYEQLSAEGKAVRVVSMPSTDAFDKQDAAYREAVLPAAVTKRIAIEAGIADFWYKYVGFGGRIIGMTSFGESAPAGELFKLFGFTTENVVKQAKELLA
What is the function of this protein?
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
What are the official names of this protein?
Transketolase 1, TK 1.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: PURR_YERPY
Sequence: MATIKDVAKHAGVSTTTVSHVINKTRFVAENTKAAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAPYFAEVIEAVENSCYSKGYTLILCNSHNNLDKQKAYLAMLAQKRVDGLLVMCSEYPDQLLGMLEDYRNIPMVVMDWGTARGDFTDSIIDNAFEGGYLAGRYLIERGHRDIGAIPGQLARNTGGGRHQGFLKALEEANIPVREEWIVQGDFEPESGYKAMHQILTQKHRPTAVFCGGDIMAMGAICAADELGLRVPQDISVIGYDNVRNARYFSPALTTIHQPKERLGETAFAMLLDRIVSKREDPQTIEVHPKLVERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: RL14_METST
Sequence: MKAITSNVSKSLPIGARLKCIDNTGAREVEIISVKGFKGVRRRLASAGVGDMVVISVKKGTADMRREVTTAVVVRQKKEYRRADGLRVKFEDNAAVIITEDGVLKGSEIRGPIAKEAADLWPAIGSAASIIV
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RR2_ILLOL
Sequence: MTRRYWNINLEEMLEAGVHFGHGTRKWNPRMAPYISAKRKGIHITNLTRTARSLSEACDLVFDAASRGKHFLIVGTKDKAADSVASAAIRARCHYVNKKWLGGMLTNWFTTETRLHKFRDLRAEQKTGRLNRLPKRDAAMLKRKLSHLQAYLGGIKYMTGLPDIVIIIDQQEEYTAIRECATLGIPTICLIDTNCDPDLADIPIPANDDAIASIRLILNKLVSAICEGRSSYIRNH
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL22_LIGS1
Sequence: MAEQVTSAKATAKTVRIPARKARLVIDLIRGKSVAEAFGILKFTPRSGAYLIEKVLKSAVANAENNFDLDVEDLYVSEAFVNEGPTLKRFRPRAKGSASPINKRTSHITVVVSVK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: AMPP3_EMENI
Sequence: MTSLDSILADKYPAKAHARRVAEGLKALGHSGGAIYLEAQKTRLIEDNDEPVPFRQRRPFFYLSGCLLPDSSLVYNIDSDQLTLFIPPINPDDVIWSGLPLSAAEALERYDVDNVLETTEVNATLANIAASHANNSTAFAIAEQVSEGTKFEGFSETNFNVLKGVIERTRVVKDSYEIALLRKANDISAKGHIAAIKASKSATNEREIEAAFIATCIANGAREQSYHPIVACGQNGATLHYGKNDEDLIDPVTNRRKDNVLIDAGAEYRTYCADITRAFPLNGKFLPETRQIYEIVLRMQLECIDMLKEGVQWEDVHAHAHRVAIRGLLELGILRGSEDELFDKRISVAFFPHGLGHYLGMDTHDTGGNPNYEDTDTMFRYLRVRGRLPAGSVITVEPGIYFCRFIIEPFLKNPDLQKYIDVGTLNRYWRVGGVRIEDNVHITKDGHDNLTTAPKTIEEVESLAA
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase pepP, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: RNH2_PARDP
Sequence: MNWPDYSLEEAALRSGARFVAGVDEVGRGPLAGPVTAAAVILDAGCIPEGLNDSKKLTAKRREALAELVMARCDWAVGHASVEEIDRLNILRASHLAMCRAIAGLRQRPCLVLVDGNMLPRDLDLPGQAVVGGDARCLSIAAASILAKLLRDRIMVDLAQQHPGYGWEANAGYPTPAHRQALLDLGVTPYHRRSFAPVHKILCKEETATR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T178A_MOUSE
Sequence: MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLMPLSHLPLRDSPPLGRRLLPGGPGRSDPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYFLGIDRDIDTLILKGIAQRCTAIKYHFSQPIRLRNIPFNLTKTIQQDEWHLLHLRRITAGFLGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASVSYDLNRVPKLIYSLPHDVEHGYSWSIFCAWCSLGFIVAAGGLCIAYPFISRTKIAHLKSGRDSTV
What is the function of this protein?
Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1 (PubMed:26644563).
What are the official names of this protein?
Transmembrane protein 178A.
What is the protein family that this protein belongs to?
Belongs to the TMEM178 family.
Protein: RS17_COXBU
Sequence: MNKNEKMVRSLMGTVVSNKMNDTVVVRVERRVKHPKYGKFIKRSTKIHAHDKGNEGQIGDIVTIRECRPISKTKSWTLVKINERAEKVE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ASTD_SHEHH
Sequence: MTQFIEGKWVAGLGHEVTSINPANQEVIWNSKTATPEQVSQAVDAARNAQFDWFMLGFEGRLAIVEAYRDQLEANKAEMAEVIAQETGKPQWETATEAGAMIGKIGLSVAAYHKRTGTSESETPAGRAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPKVAELMLKLWEKAGLPAGVINLVQGEVETGKALAAHPQIDGLFFTGSSRTGHILHQQYAGDPGKILALEMGGNNPLIIKDVADTKAAVHDIIQSAYISAGQRCTCARRLYVEKGATGDALLEQLVAAIKQIKVGPWNAQPQPFMGSMISETAAKGMVEAQRNLLNLGANSLVELTHIEAGTGLVSPGLIDVTGVIELPDEEYFGPLLQVVRYSDFDEAIKLANTTRYGLSAGILADSREDYDYFLARIRAGIVNWNKQITGASGAAPFGGVGASGNHRASAFYAADYCAYPVASVEADAVSLPATLSPGLSL
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: XPO7_CHICK
Sequence: MADHVQSLAQLENLCKQLYETTDTATRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDEYVFRNVITDVTRFLQDSVEHCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLDDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSATASPMDVAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFETVAQMFSTNTFNEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITTYGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLTQESDRFLHIMQQHPEMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSPYGVNSNDMMS
What is the function of this protein?
Mediates the nuclear export of proteins (cargos) with broad substrate specificity.
What are the official names of this protein?
Exportin-7.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CYSJ_PHOLL
Sequence: MSIKPPSISLLPVSPEQLVRLQSEIGDFSPTQLAWLSGYFWGMVNQQPQVQAVVPAVPAQETITLISASQTGNARRLAEQLREDLLAQKLNVNLFNAGDYKFKQIAQEKILIIIASTQGEGEPAEEAVALYKYLYSKKVPKLNDTVFAVFGLGDTSYERFCQAGKDFDNRLNELGAQRLLERVDGDVEYQQVADQWRKQLTGILKQRIPTETGTEITSAQDRSVNEVFSTSYTKQAPLTAALATCQKITGRGSDKDVRHIEIDLGDSGLRYQPGDALGVWFENDPELVDEVLNLLWLQGTEQVEVNGQKLSLREALISHVELTQNTSVIVEKYAVLAKDEKLLSLIADKQALQQYAHNKPIADMIREAASQPEAQQFIDLLRPLTPRLYSISSSQAEMENEVHLTVGVVRYEIDGRARTGGASGYLADRLQENSDIRIFIEHNDNFRLPADPRTPVIMIGPGTGIAPFRAFMQQREADGAEGKNWLFFGNPHFTEDFLYQVEWQRYVKDGLLTRIDLAWSRDQQHKIYVQDKLREQGEAVWCWIKEGAHLYVCGDANRMAKDVEHALLDIIAEHGGMDTEQADEFLSELRFERRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: RS2_STRPZ
Sequence: MAVISMKQLLECGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQQTVKLADQAYEFVRDAAANDAVILFVGTKKQAAEAVADEATRAGQYFINHRWLGGTLTNWGTIQKRIARLKEIKRMEEEGTFDVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDVMYVVDPHKEQIAVKEAKKLGIPVVAMVDTNADPDDIDIIIPANDDAIRAVKLITAKLADAIIEGRQGEDADIAFEADTQADSIEEIVEVVEGDNA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PHO85_DEBHA
Sequence: MTGSSSQFQQLEKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIREISLMKELDHENIVTLYDVIHTENKLTLVFEFMDKDLKKYMEAHGNQGALDLKIVKSFIFQLLKGIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEVVTLWYRAPDVLLGSRAYTASIDIWSAGCIFAEMCTGKPLFPGTSNDDQLIKIFRLMGTPNERTWPGVSSYANFKNNWQIFVPQDLRLLIPNLDSMGLNLLSSLLQMRPDARITARQALQHPWFHEISNPNPLMQHLADPYQQSQQQSQQQAQQSQQMDPQTYR
What is the function of this protein?
When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.
What are the official names of this protein?
Negative regulator of the PHO system, Serine/threonine-protein kinase PHO85.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: Y2743_TRIEI
Sequence: MASTSSFDIVSDFDRQELVNAIDQAEREIKARYDLKDSNTSLELGEDTITINTSSQFSLDAVHTVLQTKAAKRNLSLKIFDFGKVESASGNRVRQEVKLQKGISQENAKKITKLIKDEFKKVQSSIQGDAVRVSAKSKDELQAVMQRLKAEDFPMPLQFTNYR
What are the official names of this protein?
UPF0234 protein Tery_2743.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: METRL_HUMAN
Sequence: MRGAARAAWGRAGQPWPRPPAPGPPPPPLPLLLLLLAGLLGGAGAQYSSDRCSWKGSGLTHEAHRKEVEQVYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGRVQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGSIQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEARLGCAPRFKDFQRMYRDAQERGLNPCEVGTD
What is the function of this protein?
Hormone induced following exercise or cold exposure that promotes energy expenditure.  Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation.  Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance.  Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions.  Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat.  Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
What are the official names of this protein?
Meteorin-like protein, Subfatin.
What is the protein family that this protein belongs to?
Belongs to the meteorin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KCC2D_CHICK
Sequence: MASTATCTRFTDEYQLFEELGKGAFSVVRRCMKITTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGTGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPINA
What is the function of this protein?
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system.
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type II delta chain, CaM kinase II subunit delta, CaM-kinase II delta chain, CaMK-II subunit delta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.