PharMolix/UniProtQA huggingface dataset:
Protein: LEXA_CAUVC
Sequence: MLTRKQHELLMFIHERIKETGVSPSFDEMKEALDLASKSGIHRLITALEERGFIRRLAHRARALEVVKLPQQATAAAPPKGRGAFRPQVFEGGGAPPPAASPAAAANDSRELPILGRIAAGTPIDAIQHERERLPVPEAMLGAGEHYVLEVQGDSMIEAGILDGDYVIIKKGDTATSGEIVVALVGEEATLKRLRKKGGSIALEAANPKYETRIFGPDQVEVQGKLVGLIRRYH
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: PCKA_GEOTN
Sequence: MGIAKMTNKLSLLLQKPYVHHQLSVAELVEKVLHRNEGRLTHTGAVAVTTGKYTGRSPKDKYIVEEPSTKQNIDWGTVNQPMAPETFQKLYDKVLDYLMKKDELFVFKGFAGADPKARLPIQVVNEFAWHNLFVHQLFIRPSAEELADHEPQFTVICAPNFKADPAVDGTRSEAFIIISFEQRTVLIGGTEYAGEMKKSIFSVMNYLLPEQGILPMHCSANVGQEGDVALFFGLSGTGKTTLSTDPKRRLIGDDEHGWSSRGIFNIEGGCYAKCINLSREKEPQIFDAIGFGAVLENVILHDATRVPDYDDGTLTENTRAAYPLQAIKNIVDPSVAGHPSTIVFLTADAFGVLPPISKLTREQAMYHFLSGYTSKLAGTERGVTEPEATFSTCFGAPFLPRPAVEYAEMLGQKIAEHNVRVFLVNTGWTGGPYGVGSRMKLAYTRAMVQAAVEGELDNVETVQDPIFGLAIPAHVPGVPDDVLRPQNTWADKQAYEQKAKELAEKFRANFQKFAHIDPSIEKLGGPLV
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_ALKCK
Sequence: MTSTLTPREIVERLNQYIVGQDGAKRSVAVALRNRYRRTKLDPSMREEITPKNILMIGPTGVGKTEIARRLAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVESSVRLVKEERVALVKDEAKQLADKRLIELLVPSMKKETNYKNPFEMLFSQPDKEEEEDGEEELTRANLKRKMAEKLKQGELEERTVTVEVTEQNHGFMDLFQGGAGMEQMGMNMQEMLSNMMPKKKKKRRMTVAEARGVLAEEEAQKLIDMDDVTQEAITRAEQLGIIFIDEIDKVAGKNDQGANVSREGVQRDILPIVEGSTVVTKYGAVKTDHILFIAAGAFHMAKPADLIPELQGRFPIRVELQSLSVDDFVRILVEPDNALTKQYEALLQTEGIEMKFSDEAVRKIATIASEVNQETENIGARRLHTLLEKLLEDLSFEAADIHLETLEITEQYVEEKLGSIAKNRDLSQFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_METB6
Sequence: MRIKICGITRVEDVLFAEKAGADAIGVVMYSPTSRRSVPDAKAREIFSALGPFVTRVVVTHTESESDLEKILAIRPDAIQISHPFVFEKYPGVRVLRVIGRGDAVPTDCDAVIVDESMGAGKAFDQEFAKVVAKTSRVPVILAGGLTPENVGLAIREIRPHAVDVASGVETEPGIKDHTKIAAFIRAAREADHGT
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: APAH_PSEMY
Sequence: MAVYAVGDLQGCLQPLKCLLEQVAFDPAQDQLWLVGDLVNRGPQSLETLRFLYSIRHALTCVLGNHDLHLLAVAHNIERLKKGDTLREILDAPDRDDLLDWLRLQKLVHHDAERQITLVHAGIPPQWSLAKALKRAAEVEEVLRDDARLPLFLDGMYGNEPAKWNKDLHGVTRLRVITNYFTRMRFCTADGTLDLKSKEGVGSAPPGFAPWFSHPQRKMRGEKIIFGHWAALDGNCQEPGLYALDTGCVWGGAMTLLNVDSGALHRCTCPKQ
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: NSRR_VIBVU
Sequence: MQLTSFTDYALRTLIYLASLPDNEQTNITDVTELFGVSRNHMVKVINRLGQLNYIQTVRGKNGGIRLNRPAKTILVGEVVRDLEPLDLVNCSVEFCHITPACRLKERLYRAKLAFLAELDDCSIAELLDDNAELLILLQKA
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: SP381_YEAS7
Sequence: MSFRHFKRRLDTSSADESSSADEEHPDQNVSLTEKSTSLSHSDLGGEILNDTGKNRTPNDGQESNESDESPESEESSDNSDSSDSDDMRPLPRPLFMKKKANNLQKATKIDQPWNTQDDARVLQTKKENMIKNIDKANQVAKNYETMKLRLNTNYSTNEELIKQCMLLDDNDEVDSEKERQKWFERQNERKQKHRRIQLAKQRESEEYEAKRFEAM
What is the function of this protein?
Component of the spliceosome and rRNA processing machinery.  In association with the spliceosomal U4/U6. U5 tri-snRNP particle, required for splicing of pre-mRNA (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor SPP381, Suppressor of PRP38-1 mutation.
What is the protein family that this protein belongs to?
Belongs to the SPP381 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS7_CAMC5
Sequence: MRRRKAPVREVLPDPIYGNKVITKFINSLMYDGKKSVATEIMYGALKAIEKKGGDVKGIDVFNDAIENVKPILEVKSRRVGGATYQVPVEVRPVRQQALAIRWLITYARKRSERTMIDKLANELLDAANSKGASFKKKEDTYKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SMA2_CANGA
Sequence: MLIVKRFILWVLLFFMAITQLLLYLPDFSCSISTGLPLCTPQFNVNIVTGSRTTKDFVSSVRQFLRLISYLAIDMGWSKYLADPHIYNEENLVDTFDTDNLFKINYFGFCKKTSGKTKYCVANGDCGMDVLGILVRDVGLQLGRLTQRYENNTRILGDSLVFTYHLGLSSMRKFLRNDNYRNNAFSKLLLATDDQPYSNTRIKNYAKGVTVAYTLVVVNKIMFYMHLAEITISAAFVVAVLGFGFVLIFGKHHTIMPLLLKGWGSVLMVSSTSSYLATIVYLGTLKLLEPTEMLDTQSQVAGHVLNNDTHSNNWDLLQTTVGSGFVISCFRYIVQCLMLPLVFIAANRYTKAKDFLPAGTEELIKV
What is the function of this protein?
Involved in spore and ascus formation.  Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane (By similarity).
What are the official names of this protein?
Spore membrane assembly protein 2.
What is the protein family that this protein belongs to?
Belongs to the SMA2 family.
What are the subcellular locations of this protein?
Prospore membrane; Multi-pass membrane protein.
Protein: RS7_AGRVS
Sequence: MSRRHKAEKREINPDPKFGDLVVTKFMNAIMLHGKKSVAESIVYGAFDVVEAKSKAEPIAIFHQALENVAPHVEVRSRRVGGATYQVPVDVRPERRQALAIRWLIIAARKRNETTMVDRLSGELLDASNNRGSAVKKREDTHKMADANRAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ACHA3_CARAU
Sequence: MNSASRITLFFLLTVLITQECLSSKGEDRLFRRLFRRYNQFIRPVENVSDPVTVEFEVSISQLVKVDEVNQIMETNLWLRHIWNDYKLKWLPAEFDGIEFIRVPSNKIWRPDIVLYNNAVGDFLVEDKTKALLKYDGTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVLIGSKVNLKDFWESGEWEIIDAPGYKHDIKYNCCEEIYPDITYSFYIRRLPLFYTINLIIPCLLISFLTILVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMTHTMPSWVRTVFLRALPRVMLMRRPIDLSESSGKGGGEIAGSSGTGGGRGAEGKKMKSSASQQGAMNSLEFGEGKAALEGKKGGCPCHPIKEAIEGDCGKVSRQLTPQAINTVVTFSVVSPEIKQAIESVKYIAENMRSRNKAKEVEDDWKYVAMVIDRIFLWVFVLVCVLGTLGLFLQPLIGFFS
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-3, GF-alpha-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: MSCL_LACLA
Sequence: MLKEFKNFILRGNVLDLAVGVIIGAAFTALVKSLVDNLINPLIGMFVQSTALAHLSVTVGKTKFTYGAFLNDVINFIITAFVIFILIKFINKLFPKKEETVEEQKNEELETLQEIRDLLKKQ
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EF2_METB6
Sequence: MSRGKKTVERVVELMKDPKHIRNIGIVAHIDHGKTTLSDNLLAGAGIISEELAGKQLFMDSDAEEQARGITIDASNVSMVHEVEGQDYLINMIDTPGHVDFGGDVTRAMRAVDGAVVLVDAVEGTMPQTETVLRQALKEQVRPVLFINKVDRLVNELKVDETEMQIRLGKVIDKVNKLIKGMNEDLYNNGWKLDASKGTVAFGSALYNWAVSVPYMKKGGVSFKDVFEKCRAGDMKYLAKNSPLYEVVLDMVVHHLPNPLEAQPRRVNVIWHGDHSTKEGKAMLACDPNGPATMMVTDISFDPHAGEVATGRLFSGTLRRGDGLYVMGSAKKENRLQQVGIFMGPKRVEVEEIVAGNIAAVTGLKDAIVGSTVTSLMEMSPFESLKHYSEPVMTVAVEAKNMKDLPKLVEVLRQVAKEDPTLGIAINEETGEHLISGMGELHLEIVTGRIKRDKGVEIVTSEPIVVYRETVTGKVEDVEGKSPNRHNRFYFTLEPLPEEIVNLIKAGEITMNQQAIERRDVLLKAGMDKDEAKNVKHIKGTNMLIDMTKGIQYLNETMELIIEGINEALAGGPLADEPVQNLKMTLTDVKLHEDAIHRGPAQVIPAVRGAIKGGMLIAGDSLLEPVQKIQISVPMDQMGAATSQIQGRRGQVFDMQSEGDTITVVGKAPVAELFGFAGDIRSATEGRAMWNTEFAGFELVPNNLVKDVVVAIRKRKGLKEQMPTPSDYLSV
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL332_LISMO
Sequence: MKKKTSLACSECGSRNYTVNVSGTQKETRLEVKKFCRHCNKHTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: SCOTP_RAT
Sequence: SDNNQQGKSAQQGGY
What are the official names of this protein?
Scotophobin.
Protein: FIXB_ECO24
Sequence: MNTFSQVWVFSDTPSRLPELMNGAQALANQINTFVLNDADGAQAIQLGANHVWKLNGKPDDRMIEDYAGVMADTIRQHGADGLVLLPNTRRGKLLAAKLGYRLKVAVSNDASTVSVQDGKATVKHMVYGGLAIGEERIATPYAVLTISSGTFDAAQPDASRTGETHTVEWQAPAVAITRTATQARQSNSVDLDKARLVVSVGRGIGSKENIALAEQLCKAIGAELACSRPVAENEKWMEHERYVGISNLMLKPELYLAVGISGQIQHMVGANASQTIFAINKDKNAPIFQYADYGIVGDAVKILPALIAALAR
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixB.
What is the protein family that this protein belongs to?
Belongs to the ETF alpha-subunit/FixB family.
Protein: HTPX_AGRRK
Sequence: MNLMRTAMLLAFMTALFMGVGYLIGGQSGMMIAFVAAAGMNFFSYWNSDRMVLSTYGAQEVDERSAPEFYGIVRDLARNAGLPMPKVYLYDNPQPNAFATGRNPQNAAVAASTGLLHALTPQEVAGVMAHELAHVQNRDTLTMTITATLAGAISMLGNFAFFFGGRRDNNNPLGAIGVLAAMIVAPLAAMLVQMAISRTREYSADRRGAEICGNPLWLASALGKIARGAAHIPNEEAEGHPATAHMFIINPLSGARMDNLFSTHPDTENRIAALHEMAQYGGGTGPSVGTPTRSGSTGPAMTANPERKSRSVPNTGRGGSQPPKGPWS
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: H3L5_ARATH
Sequence: MARTKQTARISTGGKAPRKQLAPKAARQSAPATGGVKKPHRFRPGTVALRDIRKYQKSTEILIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKEIQLARRIRGERARGE
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
What are the official names of this protein?
Histone H3-like 5.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SYR_ACIF2
Sequence: MKAFVSQALQGALQQLHAQGRIPGIPATLELDRPKQVEHGHLASNVALLLAKAVGRKPRDIADDIVAALPASDWIARTEIAGPGFINFFLQPAAFHAVIHRVRTEKEHFGANRNGAGQRLQMEFVSANPTGPLHVGHGRGAAYGASLANILRFNGFDIFCEYYVNDAGRQMDILAASVYLRYLEADKALPWPFPENGYRGDYVREIAAHLREQVGDRLRHAAVGLPNLPQMSDGDIAIDTLIAHLKQSLGEDYRTLHSAGLDEILADIRDDLEGFGVHYERWYSEGSLMDTGAVDSAVAALEKAGHCYTQEGALWFRATAFDDDKDRVLRRDNGAYTYFASDVAYHAEKFARGFTHVIDMWGADHHGYVPRVKAALRALGLDDQQLEVVLVQFAILYRGTEKISMSTRAGEFVTLRELREEVGNDAARFFYVLRRADQHLDFDLELAKKHSEENPVFYIQYAHARVYSLLRQSVEKGLSLPPADGVGLEILQESREIALADALWRFPEVVATAARDREPHQIAFYLRELAAAFHTYYNSTRILVEETPLRHARLTLCLAVAQSIANGLRLLGVSAPEQM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOA2_CANLF
Sequence: MKLLAVTVLLLVICSLEGAFVRRQAEEPNLQSLVSQYFQTVTDYGKDLMEKAKGPELQAQAKAYFEKTQEQLTPLVKKAGTDLLNFLSNFMDLKTQPATQ
What is the function of this protein?
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
What are the official names of this protein?
Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MSHB_THEBD
Sequence: MADRRVLFVHAHPDDESIETGATIARYAAEGAHVTLVTCTLGEEGEIIPPELAHHAADRDDTLGRYRIGELAAACAALGVTDHRFLGGVGRWRDSGMMGAPSNLRPDCFWQADLDEAAAELVKVIREVRPQVLVTYDENGTYGHPDHIKAHRVSWRAYELAADPAFPGGEPWRIAKVYHTAQPRSVLRRGVEAMRGADMPFTRVASVDELPFGCDDAQVTTEIDARAHLPAKFAALRAHATQVMVHEPWFALSNGIGREVLGVEFFTLKAGTPGPRVAGVPAGEGGLGGPRLLETDLFAGIG
What is the function of this protein?
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
What are the official names of this protein?
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, GlcNAc-Ins deacetylase, N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family.
Protein: NDH_STAA8
Sequence: MAQDRKKVLVLGAGYAGLQTVTKLQKAISTEEAEITLINKNEYHYEATWLHEASAGTLNYEDVLYPVESVLKKDKVNFVQAEVTKIDRDAKKVETNQGIYDFDILVVALGFVSETFGIEGMKDHAFQIENVITARELSRHIEDKFANYAASKEKDDNDLSILVGGAGFTGVEFLGELTDRIPELCSKYGVDQNKVKITCVEAAPKMLPMFSEELVNHAVSYLEDRGVEFKIATPIVACNEKGFVVEVDGEKQQLNAGTSVWAAGVRGSKLMEESFEGVKRGRIVTKQDLTINGYDNIFVIGDCSAFIPAGEERPLPTTAQIAMQQGESVAKNIKRILNGESTEEFEYVDRGTVCSLGSHDGVGMVFGKPIAGKKAAFMKKVIDTRAVFKIGGIGLAFKKGKF
What is the function of this protein?
Alternative, nonproton pumping NADH:quinone oxidoreductase that delivers electrons to the respiratory chain by oxidation of NADH and reduction of quinones, and contributes to the regeneration of NAD(+) (PubMed:26172206, PubMed:28801048).  Can use DMN, a menaquinone analog, 2,3-dimethoxy-5,6-dimethyl-benzoquinone (DDB), an ubiquinone analog, or 2,3,5,6-tetramethyl-1,4-benzoquinone (Duroquinone, DQ) a plastoquinone analog as electron acceptors (PubMed:26172206).
What are the official names of this protein?
Type II NADH:quinone oxidoreductase, NDH-2.
What is the protein family that this protein belongs to?
Belongs to the NADH dehydrogenase family.
What are the subcellular locations of this protein?
Cell membrane. Note=Interacts with the membrane via an anti-parallel three-stranded beta-sheet followed by two helices arranged in a helix-turn-helix motif at the C-terminal region.
Protein: UVRC_PSYCK
Sequence: MVNVSESSPIDDKKARLKHLIQRLPNLPGVYKMLGKNGDILYVGKAKSLKSRVNSYFAKTIDHPKTRALVARIHNIETIITRSETEALLLEQNLIKEYRPPYNVLLRDDKSYLYVFISADKPYPRLAYGRGKGNHQKGRFFGPFPSAHAAKETLVLMQKMFQMRQCTNTFFKQRKRPCLEYQIKRCRAPCVGLVSPEEYSEDVNNTIRFLKGDSSDIHTALIEKMEASAEELDFEKAVFYRDQLSMLREVQAKQAVYTVQGEADVIAIASQGGMTCVNVLTVRGGRVLGGKNYFPDVDSSEPLADNLSAFITSFYFQVTDDLPAEIILSDELPDQLAVSEALATHFGSKVVIKTSVREHRAEWLDLAKLNTNNALKTKLGDYLELHARFGALKDVLTEVTDRTIDRIECFDISHTMGEATIGSCVVFDQGGSRRRDYRQYAIHDIVGGDDYAAMKQVLTRRYKKQPLPDLLLIDGGKGQLGIAKEVLTELGILGDTLLISVAKGEGRKAGLEVLHFIDHEPLDLPMDSKALHLLMHIRDEAHRFAITAHRKKRDKRRSSSVLEVIPGLGEKRRRDLLNHFGGMQQLLGASQQELAGVQGIGPVLAKTVYKVLHE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HVM54_MOUSE
Sequence: MNFGLSLIFLVLVLKGVLCEVKLVESGGGLVQPGGSLKLSCAASGFTFSSYTMSWVRQTPEKRLEWVAYISNGGGSTYYPDTVKGRFTISRDNAKNNLYLQMSSLKSEDTAMYYCAR
What are the official names of this protein?
Ig heavy chain V region 5-84.
Protein: CAHM2_BOVIN
Sequence: MAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFTVVAFHCPCSPARNYLYGLAAIGVPALALFLIGVILNNHTWNLVAECQYRRTKNCSAAPNFLLLSSIVGRAAVAPVTWSVISLLRGEAYVCALSEFVNPHSLMVGERSFPVAHATEILARFPCGEGPANLSVFREEVSRRLKYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALDKDDEELVAKFPVEGTQPRLQWNAITGVYLYRENQGLPLYSRLHKWAQGVVGNGMTPDHVEMSLLPS
What is the function of this protein?
Pore-forming subunit of a voltage-gated ion channel.
What are the official names of this protein?
Calcium homeostasis modulator protein 2, Protein FAM26B.
What is the protein family that this protein belongs to?
Belongs to the CALHM family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: M1_I02A0
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYKKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTTEVALGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLTSTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: GCSPA_DICT6
Sequence: MTYFPHTPQEIKEMLNTIGLESIEDLFSEIPEEIRQKAKENFKIPASPSEIDLLEEIKNIARKNIGKDYISFLGGGAYKHYIPPFVKLVSLFPTFYTAYTPYQPEISQGVLQSIFEYQSLICDLTGMEVANASLYEAGSGIAEAALMSVRITGKKEVIASSGLNPEYISVLKTYLQAQNIELKIIPLDEKGETDVDFLEKNISPKTSGVIIQNPNFFGVIETKLKDIEELIHKNNALFILSIYPISLGILKPPSEYNVDIVVGEGQSLGIPLGFGGPYLGILATKKEFIRQIPGRIVGETIDLEGERGFVNTLQTREQHIRRAKATSNICTNEALSAISAAVYMAILGKKGIKKIAEVCFSRAHYLRERMQKEVNLEITYPNSHFFNEFVIKIPENSENFLKKLEEKKILGGIPLSRFYKDRDKEILVAVTERNSLEELEYYIKSLKEVLKKN
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: RL2_ECO45
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: THSA_STRE4
Sequence: MFIIKGEVSRKDLIREIEKAIKSDELGAFIGAGLSIPAGFCSWKELLREPAEEIGLDVEKESDLVNLAQYYSNSKKRTSIDDLIKGQFSQLVKPTENHKLLSQLPISTFWTTNYDKLIEKALENNMKKPYVKTKDEQLRGTNHNFDAIVYKLHGDVETPEDAVITRSDYEEFGYNKRKLFREVLEGDLLTKTFLFLGFSFEDPNFNYVIGRLRVLLDEKNTRKHYCIMKRVQDADEDYEYKKARQELQIEDLNRYGIFTYLVNKYDEITEILSTLVDRFRRKTIFISGSAYSYSAYSQKTGENFIHKLSFELSKNGYHIVNGYGKGVGEFVLNGVADYCLTHKSKINDFLTLMPFPQNSSLGIDLDKLYKENREQMIESCGIAIFLFGNKEAEDIASGVMDEYELSKKHGLVCLPIEYTGGASKEIYDQTTQEISDKNTISAIEQANKQCDGDIDMSVKNIVQAVKILNKEEF
What is the function of this protein?
NAD(+) hydrolyzing component (NADase) of the Thoeris antiviral defense system, composed of ThsA and ThsB (maybe SEQ_0762).  Has a low NADase activity that is strongly activated by 3' cyclic ADP-D-ribose (3'cADPR) and weakly activated by 2'cADPR (PubMed:36048923).  Upon activation binds and hydrolyzes NAD(+), leading to cell death and inhibition of phage replication (By similarity).
What are the official names of this protein?
NAD(+) hydrolase ThsA, NADase ThsA, SeThsA.
What is the protein family that this protein belongs to?
Belongs to the soluble Thoeris ThsA family.
Protein: PHNC2_NOSS1
Sequence: MSDYVIECHNLETAYVGSLNRPILNEISCHIKQGEFVVLLGLNGAGKSTLLRSLVGLVPLVRGEVHINGVAMNSRILPQIRRDVGMLFQGGGLIPQLSAIENVLCGRLGTRTTWQTLFGFPKRDRLLALELLEQLGLRELAYQKTSKLSGGQQQRVAIARALIQSPQILLADEPTTGLDVIATQQVMETLAELHAQQGMTVIAVLHDLGIAARYAQRAIILDAGRIVYEGSCDNLQAQFVVNNQ
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.