PharMolix/UniProtQA huggingface dataset:
Protein: MD19B_ARATH
Sequence: MESESVKFGGPRELGGALDLITQYKLLPHHEFFCKRSLPESLSDAHYLHNLVGDTEIRKGEGMQLDQLIPNASLSSRDTNARIQPFVLDELKEAFELNDTAPVELPPAEKGAPTTVSKSKSESKDKDRKHRKHKDKKEKDREHKKHKHKHKDRIKDKDKDKDRDKKKEKSGHHDKKRKNNGTEDADDVQRHKKSKHKSSKLDEMGAM
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Probable mediator of RNA polymerase II transcription subunit 19b.
What is the protein family that this protein belongs to?
Belongs to the plant Mediator complex subunit 19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDRP_LACGA
Sequence: MTEEKKENQKIVNLIIISDSVGDTAFNMVQAGAVQYPDVKFNYRRYPFITNREKLEKVFNEITEFENVLIAFTLIHEDEQLAAIKFAREHNMKYVDLLSGVIENIHSLTGEEPKHEIGAVHHMGQNYFDRISAMEFAVMYDDGKDPKGFLEADVVLLGVSRTSKTPLSLFLANKNLKVANLPLVPQTHIPDEIYKVDPKKIIGLTNDPSVLNEIRRQRMIAYGLNPDTTYSNMDSINAELDAANKLYKKLGCYVINVAHRSIEETAALIMEHLGIDDYAK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: PEPX_LACLM
Sequence: MRFNHFSIVDKNFDEQLAELDQLGFRWSVFWDEKKILKDFLIQSPSDMTALQATAELDVIEFLKSSIELDWEIFWNIALQLLDFVPNFDFEIGKAFEYAKNSNLPQIEAEMTTENIISAFYYLLCTRRKTGMILVEHWVSEGLLPLDNHYHFFNDKSLATFDSSLLEREVLWVESPVDSEQRGENDLIKIQIIRPKSTEKLPVVMTASPYHLGINDKANDLALHDMNVELEEKTSHEIHVEQKLPQKLSAKAKELPIVDKAPYRFTHGWTYSLNDYFLTRGFASIYVAGVGTRSSDGFQTSGDYQQIYSMTAVIDWLNGRARAYTSRKKTHEIKASWANGKVAMTGKSYLGTMAYGAATTGVEGLELILAEAGISSWYNYYRENGLVRSPGGFPGEDLDVLAALTYSRNLDGADFLKGNAEYEKRLAEMTAALDRKSGDYNQFWHDRNYLINTDKVKADVLIVHGLQDWNVTPEQAYNFWKALPEGHAKHAFLHRGAHIYMNSWQSIDFSETINAYFVAKLLDRDLNLNLPPVILQENSKDQVWTMMNDFGANTQIKLPLGKTAVSFAQFDNNYDDETFKKYSKDFNVFKKDLFENKANEAVIDLELPSMLTINGPVELELRLKLNDTKGFLSAQILDFGQKKRLEDKVRVKDFKVLDRGRNFMLDDLVELPLVESPYQLVTKGFTNLQNQSLLTVSDLKADEWFTIKFELQPTIYHLEKADKLRVILYSTDFEHTVRDNRKVTYEIDLSQSKLIIPIESVKN
What is the function of this protein?
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Xaa-Pro dipeptidyl-peptidase, X-Pro dipeptidyl-peptidase, X-prolyl-dipeptidyl aminopeptidase, X-PDAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRB_HATHI
Sequence: MNHKKEKEYKKLDTEKLKENLTELQYNVTQRNATEKPFLNKYDKHFEDGIYVDIVSGEPLFLSIDKFNSGCGWPAFSKPISRKYIKERADFSHGMSRIEVRSKNADSHLGHVFNDGPIENGGMRYCINSASLKFIAKDKLKEEGYEEFLPLFEKDKQEL
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: DNAK_ANOFW
Sequence: MSKIIGIDLGTTNSCVAVLEGGEPKVIPNPEGGRTTPSVVAFKNGERLVGEVAKRQAITNPNTIISIKRHMGTDYKVQIEGKEYTPQQISAMILQYLKSYAEAYLGEPVTRAVITVPAYFNDAQRQATKDAGRIAGLEVERIINEPTAAALAYGLDKMDEDQTILVYDLGGGTFDVSILELGDGVFEVKATAGDNHLGGDDFDQVIIDYLVEEFKKEHGIDLSKDKMALQRLKDAAEKAKKELSGVMQTQISLPFISANENGPLHLEMTLTRAKFEELSAHLVERTMGPVRQALKDAGLTPADIDKVILVGGSTRIPAVQEAIKKEIGKEPHKGVNPDEVVAIGAAIQGGVIAGDVKDVVLLDVTPLSLGIETMGGVFTKLIERNTTIPTSKSQIFTTAADNQTAVDIHVLQGERPMAADNKTLGRFQLTDIPPAPRGVPQIEVTFDIDANGIVHVRAKDLGTNKEQSITIKSSSGLSEEEIQRMIKEAEENAEADRKRKEEVELRNEADHLIFTTEKTLKELEGKVDEADVKKAQEAKDALKAALDGKDIEDIRAKKNALQEVVQQLSVKLYEQAAKQAQAQQSEGKKDDNVVDAEFEEVKEDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: KITH_XANCP
Sequence: MAKLYFYYSAMNAGKTTTLLQSAHNYRERGMRTSILTPKLDHRAGSGVVASRIGLRADGQTFDRQTELLQLIERDIAAHGPLHCVLVDEAQFLSSAQVWQLSEVVDRLRIPVLCYGLRTDFRGELFEGSQFLLAWADELEEIKTICHSGSKATMTVRVDAQGHAVQDGPQVEIGGNERYVSVSRAEFKKIMRGEGRIDPLQIALPLPPA
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP6_ROTHF
Sequence: MDVLFSIAKTVSDLKKKVVVGTIYTNVEDVVQQTNELIRTLNGNIFHTGGIGTQPQKEWNFQLPQLGTTLLNLDDNYVQSTRGIIDFLSSFIEAVCDDEIVREASRNGMQPQSPALILLSSSKFKTINFNNSSQSIKNWNAQSRRENPVYEYKNPMLFEYKNSYILQRANPQFGSVMGLRYYTTSNTCQIAAFDSTLAENAPNNTQRFVYNGRLKRPISNVLMKIEAGAPNISNPTILPDPNNQTTWLFNPVQLMNGTFTIEFYNNGQLIDMVRNMGIVTVRTFDSYRITIDMIRPAAMTQYVQRIFPQGGPYHFQATYMLTLSILDATTESVLCDSHSVEYSIVANVRRDSAMPAGTVFQPGFPWEHTLSNYTVAQEDNLERLLLIASVKRMVM
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RRP36_YEAS1
Sequence: MSYYFKNLKPDLNSDVEEDDGNLLESIMANKSKREIDEQESSDDELKTLSFGSLKKAETIIDEEDFKDTKPVHKKPITTTYREESFDEDDDSEDKSDEDAGFFEEDSEDETHHGQKVPKKKSKHAPIEQSSKKRVPRVRNIPGLEIPRNKRSNLYQDIRFDKSTGKALDSSIIRKRYQFLDEYREKEIDELQKLLQDRKFLSKIDQGEREEMEQRLKSMKSRLQSMKNKDLEREILKEYESDMNKNNNTRYHLKKSEKRKVVQKWKFDHMKAKQREKVMERKRKKRLGKEFKQFEFHNRR
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
What are the official names of this protein?
rRNA biogenesis protein RRP36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: QSEC_SALTY
Sequence: MKLTQRLSLRVRLTLIFLILVSITWAISSFVAWRKTTDNVDELFDTQLMLFARRLSTLDLNEINAPQRMAHTPKKLKHGHIDDDALAFAIFSADGKMLLHDGDNGQDIPYRYRREGFDNGYLKDDNDLWRFLWLNSADGKYRIVVGQEWDYREDMALAIVAAQLTPWLIALPFMLLILLLLLHRELRPLKKLAQALRFRSPESETPLDAKGVPSEVRPLVEALNQLFSRIHSMMVRERRFTSDAAHELRSPLAALKVQTEVAQLSGDDPLSRDKALTQLHAGIDRATRLVDQLLTLSRLDSLNNLQDVAEISLEELLQSAVMDIYHPAQQANIDVRLQLNAHDVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLHARSFTVRDNGPGVAPEILTHIGERFYRPPGQSVTGSGLGLSIVRRIATLHGMTVSFGNAAEGGFEAVVSW
What is the function of this protein?
Member of a two-component regulatory system QseB/QseC.  Activates the flagella regulon by activating transcription of FlhDC.  May activate QseB by phosphorylation (By similarity).
What are the official names of this protein?
Sensor protein QseC.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENGB_BURCM
Sequence: MAFLLHQARFYTTVNHLRDLPPTVQPEIAFAGRSNAGKSTAINVLCNQKRLAFASKTPGRTQHINYFSVGPAAEPVANLVDLPGYGYAEVPGAAKAHWEMLLSSYLATRSQLCGLILMMDSRRPLTDLDRRMIEWFVPTGKPIHTLLTKCDKLTRQESINALRNTQKGLDAYRDQGVKGKLTVQLFSALKRTGLDEAHELIESWLRPSVADEKSEPVAQ
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: FARA_CALVO
Sequence: TPNRDFMRF
What are the official names of this protein?
CalliFMRFamide-10.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MUTS_RICFE
Sequence: MNLQEFKQKYNYDVATKMMQQYLDIKFAHLDCLLLFRMGDFYEMFYEDAILASNVLGIALTKRGKNGEEEIAMCGVPYHALENYLTKLIEENYKVAICDQLETPEEAKNRGGYKAVVTRDVTRIITPGTIIEENLIASAEPNYLASLVITKNKETASLCYVDLSTSEIFVVNVPEAEILNELARLKPREILLSENLRSSNLADSIFKQLNFRITYQVDSFFAINKCEKIILDFYKMKDIKGIGEISSSQICAIGSILEYLSLTQKQNIPHLPIPRIINFHSYMTIDFATRRNLEIVTNSQGTLKGSLLNTLNHTVTKQGGRLLYNFLSSPLTNIAKINHRLNITEFFYSNLEIVKRIRELLKKTSDIERCLTRITMNRSSGRDLLSIKYTLEAATIIKGVFFDAYGFNLPDFIEKIIKPLSGDAELYNLIDESIREDAPNNLNDGGIIKHEYHPKVAQLHDLINNGKLHIEKLKDQYCKETGIDSLKISHNNVIGLFIDITAKNVNKILDPKFIHRQTTVNSVRYTTTELQKLESELANAKTLVISLEKELYADICNQVIEKASYLRMLASSLSGLDVFCNFAYIADEYDYVKPEFTDDLSFDIVKGRHPVVEKALKRESKSFVYNDCHLSEFERIWLITGPNMAGKSTFLRQNAIIAIIAQIGSFVPAKSAKIGVVDKIFSRIGAADDLIRGQSTFMAEMLETSAILAQSTKNSLIILDEVGRGTSTYDGVSIAWSVLEYIHDKLKCRCLFATHYHELTVMSNFLPALQNYTIAIEESGKDILFLHNIISGAADRSYGIHVAALAGLPASVINRAEQILLKFEKTSTGKGKNILSTESNNLSLFNLEPNKTTISSKLDEQFRTIAPDKLSPKEALELIYELKKLV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: EFTS_CLAMS
Sequence: MANFTAADVKELRDRLGAGMMDSKNALVEADGDIEKAIEILRLKGQKGNAKRGDRSTAEGLVAASEQDGAATLIELACETDFVAKNDKFIALSESVLAAVVAAGASTVEEALQAPAGEQTVDQLISDRAAILGEKIALRRVARLAGEHQEIYLHRTSKDLPPQVGVVVDYSGTDAETARSIAQHIAFANPEYLAREDVPADKVEAERAIVTEISRNEGKPEAALPKIIEGRLTGFFKQVALLEQDYAKDNKQSVKKVVEAAGLTVTGFARFKVGA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTPB_STAAR
Sequence: MKILFVCTGNTCRSPLAESIAKEVMPNHQFESRGIFAVNNQGVSNYVEDLVEEHHLAETTLSQQFTEADLKADIILTMSYSHKELIEAHFGLQNHVFTLHEYVKEAGEVIDPYGGTKEMYVHTYEELVSLILKLKDIIC
What is the function of this protein?
Dephosphorylates the phosphotyrosine-containing proteins.
What are the official names of this protein?
Low molecular weight protein-tyrosine-phosphatase PtpB, Phosphotyrosine phosphatase B, PTPase B.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Protein: PUR2_BOVIN
Sequence: MAARVLVIGNGGREHTLAWKLAQSTHVKQVLVTPGNAGTACSEKISNTDISISDHTALAQFCKDEKIEFVVVGPEAPLAAGIVGNLNSVGVRCFGPTAQAAQLESSKRFAKEFMDRHGISTARWRAFTKPKEACDFIMSADFPALVVKASGLAAGKGVIVAKSKEEACEAVREIMQGKAFGEAGETVVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDEGPNTGGMGAYCPAPQVSKDLLLKIKNNILQRTVDGMQEEGMPYTGVLYAGIMLTKNGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSILDGLLCTSLPVWLDNCAAVTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFQAGTALKDGKVVTNGGRVLTVTAIRENLISALEEARKGLAAIKFEGAVYRKDIGFRAIAFLQQPRGLTYKESGVDIAAGNMLVQKIKPLAKATSRPGCDVDLGGFAGLFDLKAAGFTDPLLACGTDGVGTKLKIAQQCSKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLRTTEAVITGIAKACKKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLPQLERITEGDAVIGIASSGLHSNGFSLVRKIVAKSSLEYSSPAPGGCGDQTLGDLLLTPTKIYSRSLLPVLRSGRVKAVAHITGGGLLENIPRVLPQKLGVNLDAQTWRVPRIFSWLQQEGHLSEEEMARTFNCGIGAALVVSEDLVKQTLQDIEQHQEEACVIGRVVACPKGSPRVKVEHLIETMQINGSVLENGTLRNHFSVQPKKARVAVLISGTGSNLQALIDSTREPSSLAHIVIVISNKAAVAGLDKAEKAGIPTRVINHKLYKNRAAFDTAIDEVLEEFSTDIVCLAGFMRILSGPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLDAGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVETLSERVKLAEHKIFPSALQLVASGAVRLGENGRICWVTED
What is the function of this protein?
Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway.
What are the official names of this protein?
Trifunctional purine biosynthetic protein adenosine-3.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GART family.
Protein: COBQ_RHOJR
Sequence: MSESRWKGALLVAGTTSDAGKSVLVAGLCRMLARRGVRVAPFKAQNMSNNSVVTLDGGEIGRAQALQAAACGLEPSVRFNPVLLKPGSDRTSQLVVRGRAVTSVGARDYIEHRQHLRAVVAEELASLRADYDVVICEGAGSPAEINLRATDLANMGLARAAGLPVIVVGDIDRGGVLAHLFGTVAVLGPDDQALIAGFVINKFRGDVSLLGPGLEQLTAVTGRPTLGVIPFAEDLWLDAEDSLGVVGDAPVGRPAPPIGDDWLRVAAIRLPRISNSTDVEALACEPGVSVRWITDPSRLQDTDLIVLPGSKSTVSDLEWLRRNGIADAIAAHAKRGGPVLGVCGGYQMLGSVIVDDVESGRGAVPGLGLLDLEVEFAPDKVLAQVRGNAHGVPVSGYEIHHGRVRRNGDQPLLHASSGAAEGSIRGAVYGTHWHGLLETDRFRRLLLDDVAEHAGRTGFVTAPDTDVAAIRTAQLDLLADLVEQNLDLRALEDLLGAGAPEGLPAIASTLVS
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: REX_KOSOT
Sequence: MPEEKIPRPTIKRLAIYYRCLEKQLLQEKNSISSKEIGELLGIKASQVRKDLSYFGEFGKRGVGYDTKKLLEGIGEILGIKKEWDTCIVGAGNLGVAIANYPGLTKSGFFVKAVFDNDPKKIGSVLASGIIIDDIQSMPEVIKKRNITIGVITVPASEAQKVADALVDAGILGIVNFAPTKISVPKNVRVEEIDISVVFRSLAFHVNMLQKGEW
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_LAWIP
Sequence: MAKLIVALDYTYASEALAMANILKKHVEWVKVGLELFTHEGPSIIQLLKRMGFKVMLDLKLFDIPNTVKGSVRSACLMDVDMLTLHILGGEHMIKAALNEVQSSIQKKSHSPLLFGVTILTSIKQGELPGYNQDIASMVLNLAAYGQQWGLHGIVCSGQELTKIKALYPSLSCLTPGIRMSYSQKDDQHRVMTPSEAVKAGSDFLVIGRPITQAEQPIKIVEDIISSIM
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: S10AE_MOUSE
Sequence: MGQCRSANAEDAQEFSDVERAIETLIKNFHKYSVAGKKETLTPAELRDLVTQQLPHLMPSNCGLEEKIANLGNCNDSKLEFGSFWELIGEAAKSVKMERPVTRS
What is the function of this protein?
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis.  Depending on the context, it can promote cell proliferation or apoptosis.  Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53.  Does not bind calcium (By similarity).
What are the official names of this protein?
Protein S100-A14, S100 calcium-binding protein A14, S114.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_STAA3
Sequence: MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLEHLRERLVGRGTESDEKIQSRINEARKEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNE_RALSO
Sequence: MTAQAPLSVAPFLQTPACPSEAPGAVLPFSLNYSRYVQRLAQARAGWAERVQAAAAGPISVAWLSARFGELFEAAAAEPEQALKRALRLLRNEVFAALAERDLSGAATLDEVTGAMTDFAEFAVRAAIAVIGQELGALHGQPVGQSSGEVQELVVVGMGKLGGRELNVSSDIDLIFLYDEEGDTQGGPRPLSNHEYFTKLGRRLINALADVTEDGYVFRVDMRLRPNGDAGPLACSLGMLEEYFVVQGREWERYAWIKGRVITDPGSPHAARVIQQLERVTTPFVFRRYLDYGVIAAIRALHAQIRAEAAKRSNAANRQHGGHDSQVQAHAPNIKLGRGGIREIEFVAQVFQLIRGGQDFGLRIRPTLEVLRAAAERGLIGADAVARLTDAYRFLRQLEHRLQYVDDAQTHNLPGAPEDQLRIARMMGFADYAALVAQLERYQDEVAQQFEQTFSDKQDNQPPCAAIWHADLLDDERTESARAQLLELGYADADSVLERLRASRHSPRYRALSEVSRQRFDLLINRALDHAARQTDADVTIARFLDFFDAISRRSSYLSLLSEYPQAMARVAHTLHASRWAADYLTRHPQLLDELLDTEALSAAPDWQGFRERVRERLRAAGDHVEMQMDILRQEHHAETFRILLQDLQGMLTVEPISDRLSDLADAVLDLTLETVWQQVSTRHREVPRFAVVAYGRLGGKELGYASDLDLIFLYDDDDERAPEVYAAYARKLITWLTSHTAAGMLFDVDTRLRPNGAAGLMVTHFEAFRRYQMREGDNAAWVWEHQALTRARFCAGDPEIGARFEALRIAVLRQPREAGPLRDEIAAMRERVLEGHANPTPLFDLKHDRGGMVDIEFTVQFLVLLHSAAYAELTRNAGNIALLRMAGELGLIDAARAARVADAYRDFRARQHKLRLDGQSAARVPAGTCAHEAAHVRALWEQVFGSIDAASPTP
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: SPAN1_BPKMV
Sequence: MPRTIVAILVLAVVALGASYGFVQSYRALGIAQGEIKRQTARAEALEVRYATLQRHVKEVAARTNTQRQEVDRALDQNRPWADRPVPAAVVDSLCNRPGARCAVRTPTD
What is the function of this protein?
Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit.  The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans.  Host outer membrane disruption is possibly due to local fusion between the inner and outer membrane performed by the spanin complex (By similarity).
What are the official names of this protein?
Probable spanin, inner membrane subunit, i-spanin.
What are the subcellular locations of this protein?
Host cell inner membrane; Single- pass type II membrane protein; Periplasmic side.
Protein: CH10_PROM5
Sequence: MAAVSLTVSTVKPLGDRIFIKVSESEEKTAGGILLPDSAKEKPQVGEVAQVGPGKLNDDGSRQTPEVSIGDKVLYSKYAGTDIKLGGDEYVLLSEKDILAVVS
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NGF_CHICK
Sequence: MHSVMSMLYYTLIIAFLIGTQAAPKSEDNGPLEYPAEHSLPSTQQSNGQHIAKAAPQTTHGRFAWMPDGTEDLNIAMDQNFFKKKRFRSSRVLFSTQPPPVSRKGQSTGFLSSAVSLNRTARTKRTAHPVLHRGEFSVCDSVSMWVGDKTTATDIKGKEVTVLGEVNINNNVFKQYFFETKCRDPRPVSSGCRGIDAKHWNSYCTTTHTFVKALTMEGKQAAWRFIRIDTACVCVLSRKSGRP
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
What are the official names of this protein?
Beta-nerve growth factor, Beta-NGF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZDH18_ARATH
Sequence: MAWNVFKFCTALRALGSIMILIVIGIIGFTYYAVVVVNYGPALLIGGVDSLLSVLVLAFFHFLLIMLLWSYFSVVVTDPGGVPTGWRPELDIEKSEGNQALIGEASVGDSSSHGVRYCRKCNQYKPPRSHHCSVCGRCILKMDHHCVWVVNCVGANNYKSFLLFLFYTFLETTVVAVSLLPIFLVFFSDGDGDITVSPGSLAASFVAFVLNIAFALSVLGFLIMHIMLVARNTTTIEAYEKHTVNWPYNVGRKTNFEQVFGSDKMYWFVPLYTEDDKKKLPALGGLDFTSRSESETEPLQSL
What is the function of this protein?
Palmitoyl acyltransferase.
What are the official names of this protein?
Probable protein S-acyltransferase 13, Probable palmitoyltransferase At4g22750, Zinc finger DHHC domain-containing protein At4g22750.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: ISCS_SHIFL
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLRNRLWNGIKDIEEVYLNGDLEHGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.  Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.