PharMolix/UniProtQA huggingface dataset:
Protein: SIP1_SCHPO
Sequence: MSLASLPLEKLTKVADVDKRETIYIDLLNYEKQLRNLNKNTREDSLQTNLNPLLSLIKKYGNFIAYPTRKLLSNCIIALLKGLEGYHQHRVLLYFVDSIHEKKDYIEIINVLSVLTSCLEEYGNQINQQETFIRFFFKYSKTNLSYGVRSIALDGLSKCIETSIQSTNEDLIKEIWKCIKSNLNTSSTNVLLSALRCAYYILGSSRLRNSELEWFKSFLFKKSSIDNSLLHSSLGRCFSALASAQADKSIEAAANAVPSTPADDENNEEVENRSTTRRFDETESFRHALRILVENYHSKHAKYESSKAVLVFAVKHLFLMQRPSFVSLNYTTIVDIILLHQSHSTSKEWLSSLEQYHCTYLFRDVIGRRFLDQSSELQGIEILLKRVLEPYLKDQSKISEIAVKTAMASTADILSRSKGSATALYSQLLDTTLQILYLGKDSLKNEVAWLLRCLLSVMPSPLMPTLLALFNRLELEFKHLRSKPKEVSPKLNVGIFNNLTLSLMSIYVAAEENPLYVASSIFSKLFNFSLDLIKSSSKLDLLAAQAQIKTGWRLLSAYVSFGPSFTRMQLSQLLILWKNALSRVPSKIHSQNFMETNADMFNRFEALQCLLSFLEYNKILFTPDVRKRVIIFLNNCLKFYKAFSLTKRLEITMPIPASDYSHLELRSLLLARIFQCFFELSQLSGMSLDDQELLSTTVSTIAELSSLQGYDTADEIVQAKAFTSPRVIPGIGSRFYAQPEEEFQTTMDDILPCYICESSSDSLSVISRSNSAKLPYVPPSLTSLIDNAIQLFASMFCHQPPKVMESTLEIMVASVTNLKSGRDILRYKAVTANTLFSIYGFLSAFDNKKVTLPDKVVSLMIELLENLTAVNDPKLIPYISKSYAFLAYLYQSKPTSVLDTIIKRAAESGDPNCRAVLILAVGHILKKVGSGVPQTTLITAYQLLKVFNTDSNDLVRECSIRASSVSLGSIAKTIPSVLTAQTRILLSYMLLPECDIDVQLLKKRNSLFFPSTLFANYLDCLINELGPNLRSDSSTSHFAFDLAHQLLLLSRDTGDNIIHVYKCYQHLYLFTPLETNSDFFIRELCGNIIDLKQPKRREISIEVLYQILLQNHEFSESCYKRHFDRLIWQSLDTTPDNKLLKNILYIWLNDYKDSDIHSWVNILLFLVGIKNTSSSERSNEQDIQNNLDEDTVSLAYGTSENASNPLFQKNYRWQTQFYAATCLKTCISEVMAENKEPAKYLISRISDLVRAAFVLSTSDNFYLKQGGFELLDTIITDFSNVMDPDFDDVSLLDQFQAQISSAFSSAFVDDSSPEIVAMSLNIASNFIGTGLLKTESQAAKILNLLKEALESSLPERAGFEENRHFKYDSKYFLRIATLSAWASLLVHSANVSYLKEFLSSNIRRLSSHWIMALRGYSRLQFGPSLVKDFVADTSFTRVQSINPKILLNIYEKSWLNIAESLTILLSTDANLIYGILSGDELSLSEEDVFFQDNINYASNRYSFNFFLFSVCFQSLLIPSTLQGFRNPVFRIMRIMTEVLTEELCTKVLYDHNVFPEVVDLLVRLILTEDWETKASIVIFVKKLALANPAHNDLKFCETDSVTSMEPTVSESVEMLFQLVKILTLALTVRVPGLRSDPAESATNKKASEFVILCFNAFLDVSNIFPAIVRVDLFATAMHVYEVIMDDQQLLKNSKQELLAALRKLLSTMVEQNDHTCTTLIYTLFEHLLNIYKETINDSDKKEKNETAFMSMVLVLTLAAPILDSEQLVVHDFLEELFSSLKSSEEDFALRTRCVTSLMLVNSKHPSMSALCRFIIYKSVTMLQNGEVLKSGDYVTEFIPALLDMHVHIPEEKKKSFLSMSIPIAAHFSILVEHADARKRIGEKLLKIMAIQPDEAKAIIQQLSPRQKKCVEEILIQNVE
What is the function of this protein?
Required for endocytosis.  Also involved in cytokinesis and cell division.
What are the official names of this protein?
Pof6 interactor protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle. Nucleus. Golgi apparatus. Note=Localizes to endocytotic vesicles.
Protein: IOLE_CLOP1
Sequence: MFNSNVKLGIAPIAWTNDDMPDLGKENTFEQCISEMALAGFKGSEVGNKYPRDVKVLKKALELRDMEIASAWFSAFLTTKPYEETEKAFIEHRDFLNAMGAKVIVVSEQGHSIQGQMETPIFDGKYVLNEEEWKTLAEGLNKLGALAKEKGMKLVYHHHMGTVVQTTEEIDKLMDLTDENLVYLLFDSGHLVYSGEDALEVLKKYVNRVKHVHLKDIRKEKVEEVKRDKLSFLQGVRKGAFTVPGDGDIDFEPIFKVLDDNNYEGYLLVEAEQDPAIANPLEYAIKARKYIKEKTNL
What is the function of this protein?
Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).
What are the official names of this protein?
Inosose dehydratase, 2-keto-myo-inositol dehydratase, 2KMI dehydratase.
What is the protein family that this protein belongs to?
Belongs to the IolE/MocC family.
Protein: CLPP_RHOP2
Sequence: MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFLTGPVEDGMSTLVVAQLLFLEAENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLAAGHKDMRFSLPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNEIYVHHTGQTYKAIEDALERDKFLTADMARDFGIVDKVIDKRAEESAPGPKVA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPA_AERPE
Sequence: MEHPWIPNSHKAILDEMLEAIGVSSVDDLYRDIPPTILLSPEEWDSLPIGEGRPLSEAEVLARINDILSRNKYFTDPPPFVGGGVWPRYVPSVVKALITRGEFLTAYTPYQAEISQGLMQALFEYQSLVAELLEMEVVNASLYDWSSAVGEAMLMARRVTRRNRVLVPETMNPLHLETATTYAYGGGIRVEKVRVDRETGFIDLEDLESRLSQGDTAALYMEYPSSYTGVIDENVEAAGEAVHKAGGLFILGVEPVSMAILKPPGRLGADIAVGDGQPLGLGLNYGGPYLGVFAVRWDGRLVRQMPGRLIGMTVDAEGRRAFAMILQTREQHIRRAKATSNITTNEALMAIAAAVYLSLLGPQGLREVAEASWYMSHYAAKRLSELRGVEAPLLEGEFIMDFTVRLPMDAGVARRRLLEKGVLAGIPLGGFSFFSDNDMLLTVTEAHTRRHVDLLVNLLDSVLGG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: TRUB_CHLTB
Sequence: MELATESIEGVLLVDKPQGRTSFSLIRSLVRLIGVKKIGHAGTLDPFATGVMVMLIGRKFTRLSDIMLFEDKEYAAVAHLGTTTDTYDCDGKIVGRSKKVPTMDEVLTCTSYFQGEIQQVPPMFSAKKVQGKKLYEYARQGLSIERRFATVTVNLRLVKYEYPRLHFVVQCSKGTYIRSIAHELGNMLGCGAYLEELRRLRSGSFSIDQCIDGNLLDEPEFNVSPYLRDANGLILQPAPVL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RL25_BACLD
Sequence: MAILKAEERTDSRRSSLRRIRQSGYVPGVIYGRNLENKSVALDSIELLKILRAEGKNTIINLDINGDQHSVMVTELQTDPLKDSIVHADFKVVDMEAEMEATVPVNLTGEAEGIKQGGVLQQPLYELSVTAKPKNIPQTIEVDISSLEVNDVLTVGDIPTKGDYSYNHEPDEVVASILPPQKQEETEAESAAQDVEEPEKGTEEEKEE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: SNX19_MOUSE
Sequence: MKAQTVSPTQGTISESSYVHSNLWSSRKLMIVGVLVGWLLVIHLLVNMWLLILLCASLVALGGWLGSTAILGASGQLHLERFITITTCPPCPEAERQLEQEINRTIQMIIRDFVLSWYRSVSHEPAFEAEMEAAMKGLVQELRRRMSIVDSHALTQRVLTLCGCHLQSYIQAKEATAKEQSCPVQPSQLWDAYCQVTAPHPAMSCPTTEVTYARGIVNLILKELVPKPHLETRTGRHVVVEVITCNVILPLISKLSDPDWIHLILVSIFSKYRHDAAQGTKPPCSSSVLEQPSVPTSLPLIVEVESLPVGKASSPATAPVHLTSSEPAPSPEIEEGHEAVEGDLPGMLEEKKVGNSSSHFLQPDIRGPLFLCEDSELESPLSELSKETILLMTPGNFLSDRIQDALCALDDSGALEPKDGEGSECMEGAEAEEAPGTDTETGMLVSVLNCPEIQIDTADKEVEQGDDTSLTALLEEPEKPCPLRPSCLDKDLASGVCSLEPAMPPVPLSSSPPGPLSSATFSFESLSSPDGPVVIQNLRITGTITAREHSGTGFHPYTLYTVKYETVLNGENSSGLQQLAYHTVNRRYREFLNLQTRLEEKPDLRKFIKNVKGPKKLFPDLPFGNMDSDRVEARKSLLESFLKQLCAIPEIGNSEEVQEFLALNTDARIAFVKKPFMVSRIDKMVVSAIVDTLKTAFPRSEPQSPTEELSEAENESKPQTEGKKASKSRLRFSSSKIAPALSIAEAQDKILYCLQEGNSESEVLSMSGMESFIEKQTKLLRIQPAEVPDKDPQQVPKEYVDSGLLDKAVVAQELNKSGPGTETELADTAFDLILLLLMEQWKWLCTESMQKFLHIIFGTLVQRWLEVQVANLTCPQRWAQYLHLLRESIWPGGVLPKFPRPGRTQAQKAATEKQALQSLMDLLPDFLVEILGVNKCRLSWSLVLESFQQPLINRHLIYCLGDIILELLDLSASVEECAPATSASDSPGSLKKMAVST
What is the function of this protein?
Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546).  May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation.  May play a role in insulin secretion (PubMed:24843546).  Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25148684).
What are the official names of this protein?
Sorting nexin-19.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ARMH1_ARMME
Sequence: MEEQVPSSANILVIGGGPAGSYAATVLAREGFEVILLEKDVFPRYHIGESMLPSCRPFLKFIDCEEKLKNHGFTMKPGAAVKLNQYKREGYTDFISTNPDNAARNVVRSEFDELLLRHASEMGVHVYEGVRVEEIHFAPDEPTRPISLTWSKEDKTRGTVSFNWLVDASGRNGLMSTRYLKNRTFNKTLRNVAVWGYWTGTSCYAPGTTRENAPWFEALIDETGWAWFIPLHNGTTSVGVVLVEEESKRKKSQYRSECKDKSPSEIQHDCYMADLQRAPGLIQLLGTATFEGKLMSAGDYSYHATEYAGSNFRLAGDAGAFIDPFFSSGIHLALTGGLSAASTIAASIRGDCTESEACGFHNSKVGTAYTRFLLVVLGVYKQIRSQETAVLYDVDEDNFDKAFHFLRPVIQGCADADEGLTEAELQSTLDFCTNVFAPTQPETHEAAIQRLGSLADPDGPLLDTDTIDKLTGTDMEAKHALWKINARKPLHSMYDCKRNFGTEIINGFYVKMEQGVLGLVRT
What is the function of this protein?
Flavin-dependent halogenase involved in the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols.  The halogenase catalyzes the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product.  The enzyme acts on free substrate and does not depend on carrier-protein-dependent acceptor molecules.
What are the official names of this protein?
Flavin-dependent halogenase armH1.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: DCL2_MAGO7
Sequence: MSSQDESASSSDTGEGGHVFGRENLNQSADYGYKTGSSASTHSTTDDAISEEPQPSGNGPRSIIARAYQLEMFQASMQQNIIVSMDTGSGKTQVAVLRIRAELERTPPEKRVWFLAPTVALCAQQYEVIRSQIKVANSIVMTGDDNVDSWSDVQTWDAVLANVRVVVCTYMILFEALSHAFVTMDSISLLVMDEAHNCTGKFPGRLIMKRFYMPRKSAGDHVPHILGLTASPVMKSDLSSMEDLESSLDSVCRGPTLQREELFANVHQPTMTVTTYKECDLRSPVQYTRNMNNLHLAFENLDIAEDPYVLHLMGQRTPKSLRELDRILTKLDTYTQNQMKALQRKSSSLFRELGQWAVDSYIYNVVEKVSNLDARSSWLGGWLDDEQRYLHRAIQGINALPVSAAIPAPEMTSIKLQVLLRILRGYEGSPVGIVFVKERATAGILSQLLAIIPDINARYKVGCMVGTSRYMSRKMNIHEVLQQGDDLLALEKFRSGAINLLVATSVLEEGIDVPVCNLVICFDMPANLKSFIQRRGRARMRESKLHLMIEEDSLVSVKDWGALEAAMKQRYENDMRELDHLAQVEEEDEMDVPPLHSRTTAAKVTVDDAKGHLEHFCRVVTRSQQYVDASPEYLVTTKTTAFVGGKPIPILGVTVLLPASLPPNLRQAHSSRDWISERNAKKDAALQAYKMLYEAGLINEHLLPIRESDFVDREVDGRPGLLEVQEQWNPWPCIVEAWETGLSSQTIHRRRLQLTDQDGMLMGELDALLPVPFPPISILKLYWIQHSEHPWTISFDPDVTMSGPGSTDPSFEIQQALDQTQILLDMAFGHRFSVSEQSKALRFIWPNRTLKLQMIGGQPFSKKAGEAHSSDYIIRSYGRDPYIYKSWVPVKPPLELVRGYWKAKPDEEEPPADAPWVVVKRLPKNCGFVKNSRIPIELPKEYQTSSPRRFDYIIPEQLCTFDTVPATLVQLGMLVPSITQAMEPYFVAQELLRRTALGSLDFKDIDLVMMVITSSSAGRLTNYERVEFLGDAVLKLGAAVTCATNNLHFPEGYLSLLKDRLVSNSRLCKAATALGLDQFIITRQYSLKQWRNMLTAPEPPTNTRKMSSKTLADVTEALIGAAYIEGGMSKALRCISLMIPNERWRSLDESRAVLYQVALNDIPLPSTLGPLEELLGYSFNKKSLLIEAITHASYNIPGSAGSSLERLEFLGDSVLDFVVVARLFSVKDPAPIEHYNMHLLRTAVVNGEFLGFLAMEWRTAATQRSVVVRTGQGTADELETVETPGLPLFGFLRHNASGDWVRDQQLAEERHAEMAPGIRDALEHGQRYPWDLLARLRISKVHSDVLEAVIGAVWVDSGSLEECEKLIERVGILRYLDRALRDGVKILHPKEELGRVAQNNKVVYKVDKAKRAARAEVYEVSGELAEGEDVEFLCSVTVGDRCVARVGGAVSKNDAMTKAALEVIRVWEEAGRSWDNVGVVLEEGV
What is the function of this protein?
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway.  Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS).  Part of a broad host defense response against viral infection and transposons.
What are the official names of this protein?
Dicer-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Dicer subfamily.
Protein: SBNO2_HUMAN
Sequence: MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFSLPPYPAFSSDSRPFMSSASFLGSQPCPDTSYAPVATASSLPPKTCDFAQDSSYFEDFSNISIFSSSVDSLSDIVDTPDFLPADSLNQVSTIWDDNPAPSTHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLALPSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQAGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGHLNCFVSAAEGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESDPGLDSDFNSSPESLVDDDVVIVDAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYEESQQVFLAPGHPQDGQVVFYKISVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSCLLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYALSLTHCSHSAWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDRKKQVGIKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLTYSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDMLRSLHAGPPSEGALGEGAGAGGAAGGGPERQSVIQFSPPFPGAQAPL
What is the function of this protein?
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions.  Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast.  Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway.  May also be required in the regulation of osteoblast differentiation (By similarity).  Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162).  Plays a role as a regulator in the pro-inflammatory cascade (PubMed:18025162).
What are the official names of this protein?
Protein strawberry notch homolog 2.
What is the protein family that this protein belongs to?
Belongs to the SBNO family.
Protein: MURG_CHLT3
Sequence: MKLIFAGGGTGGHVFPAIAIAQEILRTQQNAEIQFVGTERGIEATAVPKQGFPMHLIPVAGVKRGFSPKELFENLKVPMRLQRSLSACHDILQREKPNVVIGTGGFVSGPIVWEAQSKKIPTLIQEQNSMPGVTTRLLSLRASEVHLSFEESKTYIRRTNGVFVTGNPTRQFQSHRPAQAKAFFSLDSTRKTLLVFGGSLGARSINQAIESNLEEWLEKFNLIWQTGKLDFADIATRIGSRKNLWYNAFIDQMDMAYAAADLAVCRAGASTLAEITHLGKPSVLVPYPYAAANHQFYNAKSLADNHAALLIENKDIGLETSKTEIMSLLQNESRLKQMSENSLKLGKPHATRIIAEHVIRLAELG
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ADD_SHESM
Sequence: MINTSIPLVDLHRHLDGNVRVNTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVAVLADLDAVKRVAYENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVIDGVKAGLKDYQVKINLIGIMSRSFGQAACTQELEGLLAHKQHLVAMDLAGDELGFPGELFNEHFKRVRDAGLAITAHAGEAAGSQSMWQAIQELGATRIGHGVNAIHDPKLMEYLAKHRIGIESCPTSNLHTSTVSSYAEHPFRTFMDAGVLISLNTDDPGVSAIDIKHEYRIAKSELRLSDAELAQVQRNGVEMAFLSESERKALYAAKA
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: RK22_CYAPA
Sequence: MATEVKAIAKYVRTSPQKVRRILDQIRGKSYKEAVMLLSVMPYKACSIILKIVDSAAANAQVTKGFNKNKLIISKTFVDKGPTLKRFRPRAQGRGYKILKPTCHITVQVQDQSL
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, cyanelle.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: BRX11_ARATH
Sequence: MGRKRKHSETVTAAPVKDSAPERPQRTLLGWKDKKEDAENSKPAYASVFRNKEKVLVTCSRRINFRYRHLMLNMVSLLPHCKKDSKVEAKSSRGATLNELIELKGSSSCLFFECRKHKDLYMWMVKSPGGPSVKFLVNAVHTMEELKLTGNHLKGSRPLLTFSSNFENDAHWKLLKEMLTQIFGIPEGHRKSKPYHDHVFVFSIVDDHIWFRNYQISVPHNESDKIARGDLDKMTLIEVGPRFCLNPIKIFGGSFGGTTLYENPFYVSPNQIRALEKRNKAGKFAKKIKAKTRRKMHELSNPLEPDEFTDMWNDE
What is the function of this protein?
Involved in pre-rRNA processing and required for biogenesis of the large (60S) ribosomal subunit.  Required for proper development.
What are the official names of this protein?
Ribosome biogenesis protein BRX1 homolog 1, AtBRX1-1, Brix domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the BRX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Associates with 60S pre-ribosomes.
Protein: OBG_FRACC
Sequence: MPTFVDRVVLHATAGDGGHGCASIHREKFKPLGGPDGGDGGRGGDVRLVVDPSVTTLLDFHFHPHQRASRGRPGQGSNRHGADGADLVLPVPDGTVVLTEDGEQIIDLVGPGSAFVLARGGRGGRGNAALASARRKAPGFAELGEPGEQLDAVLELKTVADVALVGFPSAGKSSLVSVLSAAKPKIADYPFTTLVPNLGVAQAGDRPPYTVADVPGLIPGASEGRGLGLEFLRHIERCSVIVHVLDCATLEPGRDPMTDLDVIEAELAAYSADLSDRPRLVVLNKIDVPDAAELAELVAPELRARDLAVFAVSTATRRGVHALSLALADLVAQHRAAAPARAATRIVLRPRAVNEPDFTVRPLGDGFLITGSKPERWVRQTDFTNDEAIGFLADRLARLGVEKELARLGATAGAEVTIGEVTFDWEPTLSGGGLGNGGLGVDDHPGGDGLAETGPGGRGPAGTAASGAAPSPGRGGDTGSSVSLGPRGTDDRLRASVRLTRAERMARRAAAVVDPAVRGEPAGRGEEEG
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADA_BACC1
Sequence: MSILEKVQPIETMLPERYYTMSTEDMEKRVREIKEKMGETLFIPGHHYQKDEVVQFSDAAGDSLQLAQVAASNKKAKYIVFCGVHFMAETADMLTTDDQIVILPDMRAGCSMADMADIEQTERAWKELTKLFGDTMIPLTYVNSTAAIKAFCGRNGGATVTSSNAKQMVSWAFTQKERLVFLPDQHLGRNTTYDLGIPLDKMAVWDPYTDSLEYEGDIEEIQVILWKGHCSVHQNFTVKNIENVRKNQPDMNIIVHPECCYEVVAASDYAGSTKYIIDMIEAAPSGSKWAIGTEMNLVNRIIQQHPDKEIVSLNPFMCPCLTMNRIDLPHLLWALETIEKGEEINVISVDKQVTEEAVLALNRMLERV
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHI_AGRST
Sequence: MFPMVTGFMSYGQQTIRATRYIGQSFITTLSHTNRLPITIHYPYEKSITPERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWRFEKDIKRKQLLNYSIDFGVCIFCGNCVEYCPTSCLSMTEEYELSTYDRHELNYNQIALSRLPISIMEDYTIQTIRNSTKSKIDEDKSSNSRTITDY
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: KAD_ECOLC
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAMKEAGINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYHQMTAPLIGYYSKEAEAGNTKYAKVDGTKPVAEVRADLEKILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_LACLA
Sequence: MATKKIRIRLKAYEHRILDAAAEKIVETAKRTNAEVSGPIPLPTDRSVYTVIRATHKYKDSREQFEMRTHKRLIDIIEPTQKTVDSLMKLDLPSGVNIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: GARL_ENT38
Sequence: MSNDIFPNKFKAALAAKEIQIGCWSALASPISTEVLGLAGFDWLVLDGEHAPNDITTFIPQLMALKGSRSAPVVRVPTNEPVIIKRLLDIGFYNFLIPFVENVEEAVQAVASTRYPPEGIRGVSVSHRANMFGTVPDYFSQSNKNITILVQIESQHGVDNVDAIAATDGVDGIFVGPSDLAAAFGHLGNANHPEVQRAIQHIFERAKAHGKPSGILAPVEADARRYLEWGATFVAVGSDLGVFRSATQKLADSFKK
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
What are the official names of this protein?
5-keto-4-deoxy-D-glucarate aldolase, KDGluc aldolase, KDGlucA, 2-dehydro-3-deoxy-D-glucarate aldolase, 2-keto-3-deoxy-D-glucarate aldolase, 5-dehydro-4-deoxy-D-glucarate aldolase, Alpha-keto-beta-deoxy-D-glucarate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
Protein: KT3K_ECOLI
Sequence: MWQAISRLLSEQLGEGEIELRNELPGGEVHAAWHLRYAGHDFFVKCDERELLPGFTAEADQLELLSRSKTVTVPKVWAVGADRDYSFLVMDYLPPRPLDAHSAFILGQQIARLHQWSDQPQFGLDFDNALSTTPQPNTWQRRWSTFFAEQRIGWQLELAAEKGIAFGNIDAIVEHIQQRLASHQPQPSLLHGDLWSGNCALGPDGPYIFDPACYWGDRECDLAMLPLHTEQPPQIYDGYQSVSPLPADFLERQPVYQLYTLLNRARLFGGQHLVIAQQSLDRLLAA
What is the function of this protein?
Ketoamine kinase that phosphorylates ketoamines on the third carbon of the sugar moiety to generate ketoamine 3-phosphate (By similarity).  Its precise substrate are unknown: does not have ribulosamine and/or erythrulosamine 3-kinase activity in vitro (PubMed:17681011).
What are the official names of this protein?
Probable ketoamine kinase YniA.
What is the protein family that this protein belongs to?
Belongs to the fructosamine kinase family.
Protein: RLMN_PSYWF
Sequence: MTKIPMQPADSTPATFHPNAPTKTNILGMNQEQLGAYFKHIGEKPFRATQVMKWIYQHGVTDFAQMTNLSKGLREKLSEQACIELPEVMHKEFSEDGTRKWVFKVAGGSLVETVLIPADDSKVNGRKTLCISSQVGCALDCSFCSTGKQGFERDLTAAEIIGQLWVANASYMEGVDSTEWQNNVTNVVMMGMGEPLLNYTPVVSSMGLMLSDHAYGLSKRRVTLSTSGVVPKMYELYKDIDVALAISLHAPNDELRNELVPINKKYPLSELIAAAKAYVHDNNPRHKKHVTIEYVMLAGVNDSDEHAQQLVALLDGLPSKINLIPFNPFPHAPYDRSSNNRIHAFSNILNNAGFVCTIRQTRGDDIDAACGQLVGQVADRTRRSAKWQQSIKQRAANEQQSEG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.