PharMolix/UniProtQA huggingface dataset:
Protein: PSB1_THEON
Sequence: MAEKLKGTTTVGIVCKDGVVLAADRRASLGNMVLSKEVTKVFQIDDHLALAGAGSVGDILSLVRLLRAEVKLYRAKVGREISVKALATLTSNILHGSRFMPYFGWFLIAGYDEKPALYSLDMAGGVTEDKFTAAGSGMELAFAVLEDGYKDDINVEEGVKLALKAIKIATRRDVFTGDGITLVTVTEEGYRELNREEIEALLK
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 1, 20S proteasome beta subunit 1, Proteasome core protein PsmB 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FK113_ARATH
Sequence: MSENCNSRHFSWLMKSCLPNPSDAKSLVQIHQPSSTAANSSATIASLPDDLLLECISRVPSSSIPSLAVVCRRWSRLLHSPYFLHLRRRLGLLRHSLFAISTVDSGLFAADLQFQSEIASWKVSLAVSSRSVGVDGSYGSLSHARAAAIGPRVYVVSRNAVLRYDSWMGTLNLRSPMIFPRKKFAIAVVSGKIYVAGGGGGSEVAAAVEEYDPELNRWEVVTQSARKRYGCIGAAVDGVFYVIGGLKIGNETSRAVAARAYASSMDLFDVESRQWLRSRSVPGGGCVVAACAAVGYVYVLTSHAVELSFWRFDARRRGGNSGFGEWQRLKSPPLPAQVRLDGTVRFSCVGVEDKVAVVQVVGCIDDLLRRSGRGERGIRESLVLLYDTTEGEWRRAADLPEMITRAACACVEW
What are the official names of this protein?
F-box/kelch-repeat protein At5g26960.
Protein: PA24D_MOUSE
Sequence: MWSGDRRVGMESLSPERLHGHPYQEEASVFCRLTVKILEARSLPRADLLSQADPYVTVQLPTASGMKFKTQTVTNSSHPVWNETFSFLIQSQVKNILELTIYDEDVITKDDICFKVSYDVSEILPGQLLQKTFSLNPQGPEELDVELLMERTWDPPENLITNNVLVARELSHLDVSLDRAGNTAMAAGQDKLELELMLKGSYEDTQTFFPDTAFTFSFHYMRGQDTELNGYLRGPRNSGWNSDTSVTPFNVPLMSLAAGKEMTIDIPAMKAPEGKLQLKTDCCPKELSVRLSYGLCPEEQAFLSRRKKVVAAALKQALQLDEDLNEDEVPVVGINAEGGGMRAMISLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYRDPEWSQRDLEGPISHAREHVAKTLLKEFLPEHLASYRQTLKLREEQGYTVTVADLWGLVLESKLHGQVTDQKLSGQRAALERGQNPLPLYLSLNVKENHLETLHFKEWVEFSPYEVGFLKYGGFVPSELFGSEFFMGRLMKRLPESQICFLEGIWSNLFSVNLMDIWYDITYGKDSNNFPVDVRNSEKEFSGSAGTSSGVEAPWLESGTALAQALKGFLTGRPFHQRSANFLHGLQLHRDYCNQRHFSTWADCNLDDTPNQLTPQDPQLCLIDAGCFMNSSCPSLFRPGRQVDLIISFNYNQSLPFKGLQQSEKYSRARGLPFPRVEPSPEDHSQPQECYLFSDPTCPEAPVVLHFPLVNDSFRDHSAPGVRRSPDELKAGQVNLTGAASPYFMYNMTYKNEDFDRLLQLSDYNVQNNQGTILQALRTVLKRRASETRPLGVKT
What is the function of this protein?
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:15866882).  Compared to its human ortholog, may have no preference for the fatty acid found at the sn-2 position (PubMed:15866882).
What are the official names of this protein?
Cytosolic phospholipase A2 delta, cPLA2-delta, Phospholipase A2 group IVD.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to perinuclear membranes that may correspond to endoplasmic reticulum or Golgi in a calcium-dependent fashion.
Protein: VE2_BPV3
Sequence: METLQARFDAVQEQLLEIYEQDTSSLDVQITYWTLIRHEQALYYYARRQGILRLGIYQVPPTGVSEKKAKDAIKMTLFLKSLQKSEFAAQPWSLPETSLERFLAAPENTFKKRGQHVTVIYDKDSMNAMEYTLWTEIYAVDDNDQWHKYTSGVDYDGIYFTDAQGNKNYYVSFADDAALYSKLGHWEVQYENQVLSPPVTSSLPPGPNRRRGPQTRGHPRHKSASFRRSASSGSDTRDSRGRSRSPSSSRSRSRSRSRSPSGSHSRPRAPHVPDQETGRPPGGGGRRGSRDQQQGPGGPAPPSPGEVGTRSGPPETKAKGRLAELISAAYDPPVLLLQGCANTLKSFRRRTTQSYPHTFLCMSTSWTWASKTCTVKSGHRMLVAFVNSEQRTLFLATVKIPKGVTCLKGSFDGL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: URK_BACC4
Sequence: MGTNKPVVIGIAGGSGSGKTSVTKAIFDHFKGHSILILEQDYYYKDQSHLPMEERLKTNYDHPLAFDNDLLIEHLQQLLAYEQIDKPVYDYTLHTRSEEIIPVEPKDVIILEGILILEDPRLCELMDIKLFVDTDADLRILRRMQRDIKERGRTMDSVIDQYVNVVRPMHNQFIEPSKKFADIIIPEGGQNHVAIDIMVTKIATILEQKVNL
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1970_YERP3
Sequence: MSELCPCGSILNYHECCGPYILGTQVAAKPAILMRSRYCAYVEKNVDYLIATWHPDCHAQEWRESIIQGFTKTVWHGLTVIADTPGRHPDEAFVEFIARFTDADNAQITAMHERSRFLRIKEHWYYIDGIRPSLGRNDTCLCGSGKKHKKCCGR
What are the official names of this protein?
UPF0225 protein YpsIP31758_1970.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: TTCA_BURP1
Sequence: MNAPHTPHLNEAEAAAAVEANAAELGRRALTRREQKEAYENNKLFKRLVRQVGQAIGDYNMIEHGDKVMVCLSGGKDSYALLDILLRLRERAPIDFDIVAVNLDQKQPGFPEHVLPEYLTKIGVPFHIENQDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVAGELGATKIALGHHRDDIVQTLLLNMFYGGKLKGMPPKLQSDDGKNIVIRPLAYAKETDLEKYAELREFPIIPCNLCGSQPNLKRAEMKALIRDWDKRFPGRVDNMFNALANVVPSHLMDARLFPFAGLRATGEADPNGDIAFDEDPCGTDASAPGGAKSVSIVQFDDL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_XANC5
Sequence: MKDLLNLFNQQRQTLDFDAIKIALASPDLIRSWSYGEVKKPETINYRTFKPERDGLFCAAIFGPIKDYECLCGKYKRMKHRGVVCEKCGTEVTLAKVRRERMGHIDLASPVAHIWFLKSLPSRIGLMLDMTLRDIERVLYFEAYVVTEPGLTPLERRQLLTEEQYLTARQEYNDDFDAAMGAEAVYELLRTIDLQSEMTRLREEIASTGSETKLKRLTKRIKLIEAFLESGNRPEWMVMTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLRRLLELNAPDIIVRNEKRMLQESVDALLDNGRRGRAITGTNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLKLHQCGLPKKMALELFKPFVFAKLQRRGLATTIKAAKKLVEREEAEVWDILEEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLSLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMSRALENKKGEGMVFANTSEVKRAYDNRVVELHAKVKVRITQVDVEAGGKRSSGTSIVDTTVGRALLSEILPEGLPFQLANTEMTKKNISRLINSSYRLLGLKDTVVFADKLMYTGYAYATRAGVSIGIDDMLIPDEKKGILTEAEAEVLEIQEQYQSGLVTAGERYNKVVDIWSRTSERIAKAMMDTIGTEKVENAKGETIDQKSMNSLYIMADSGARGSQAQIRQLAGMRGLMARPDGSIIETPIKANFREGLNVQEYFNSTHGARKGLADTALKTANSGYLTRRLVDVAQDVVITEIDCGTTEGLIMTPIVEGGDVVEPLRERVLGRVVAEDVYLPGNDEEPIVTRNTLLDEAWVAKLEDASVQSVKVRSTISCESSFGVCARCYGRDLARGHQVNIGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAVDNITVKTTGSVKFNNLKSVAHASGSLVAVSRSGELSVLDGHGRERERYKLPYGATITAKDGDAVKAGQSVANWDPHNHPIVSEVAGFIRFIDFVDGVTVIEKTDELTGLASREITDPKRRGAQAKELRPIVRIVDAKGNDLTIPNTDLPAQYLLPPRSIVNLQDGAAVGVGDVVAKIPQEASKTRDITGGLPRVADLFEARKPKDPAILAERSGIISFGKDTKGKQRLIIKDTDGSEHEELIPKYRQIIVFEGEHVTKGETVVDGEPSPQDILRLLGVEPLAAYLVKEIQDVYRLQGVKINDKHIEVITRQMLRKVEIVDQGNSKFLNGEQVERQRVIEENARLVKRNELPAKYDPVLLGITKASLATESFISAASFQETTRVLTEAAVRGTRDNLRGLKENVIVGRLIPAGTGLAYHAGRRKASGLTDSEMETLSGKPAAAEPVAAVADAGADEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: EFTU_CHLL3
Sequence: MAKESYKRDKPHVNIGTIGHVDHGKTTLTAAITSVLSKKGFAESRAFGDIDKAPEERERGITISTAHVEYQTEKRHYAHIDCPGHADYIKNMITGAAQMDGAILVVAGTDGPMPQTREHILLARQVNVPALVVFLNKVDIADPELLELVEMELRELLTEYGFPGDDIPIIKGSALKALEGDPEGEKAILELMDAVDNYIPEPVRDVDKPFLMPVEDVFSISGRGTVGTGRIERGRIKINEEVEIVGIKDTRKSVVTGIEMFQKLLDEGQAGDNAGLLLRGVDKTELERGMVIAKPGTIKPHTKFKAEVYILKKEEGGRHTPFFTNYRPQFYFRTTDVTGAVTLPEGVEMVMPGDNLSVDVELIAPIAMDEGLRFAIREGGRTVGAGSVTKISE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_ACHLI
Sequence: MNKQQKPKRSPLRPDYLVIVIIILLAIGMYFFFTEMMAPKVKQFDEFEFIAAIESGQIATVRSEYVGGDNFNLWEVTGTFTTGNAPEGVGSYVIILYGDRLNNIQDIIITYNELNPSTPITVSFVPHVSVDFWNIISTLLLIAAPIVLVVIMFRSMSSQSNKAQDFTKNRAKLSQGRKVKFSDIAGADEEKAEMAELIDFLKNPKKYADMGARVPKGVLLVGQPGTGKTLLAKAVAGEAQVPFFSISGSDFVELYVGVGASRVRDLFKVAKQSAPCIIFIDEIDAVGRQRGAGMGGGNDEREQTLNQLLVEMDGFSANLGIIIMAATNRPDVLDPALLRPGRFDRQITMQVPDQKSREEILKVHARSKKLDPTIKFSEVAMRIPGFTGADIENLLNEAALLAARESRTVISMQDIDEAADRVTMGPAKKSRKYSPNEKKMVAYHEAGHAVIGLKVNLASTVQKVTIVPRGRAGGYALYTPVEEKFNYAKSELLAMITSALGGRVAEEIMFDDVTTGAYDDFKRATKLARSMVTEYGMSDLGPIQYESDSGNVFLGRDYLKDKNFSDAVALEIDREVRAIITECYEHARKVINENKNLLDNIAKYLIAVETLTKTDIDEIAATGQLQWWDNREVEEDSKKSE
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: NDK_PYRAB
Sequence: MCENEKERTLVIIKPDAVIRGLIGEIISRFEKRGLKIVGMKMIWISKELAEKHYAEHREKPFFKSLVEYITRTPVVVMVVEGRCAIEVVRKMAGATDPKNAEPGTIRGDFALEVSDAICNVVHASDSKESAEREIKLYFRDDEIFDYPRAEDWFYRKGI
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXB_SHESH
Sequence: MKILADENMPYVEQLFGDLGTIEAVNGRTLTSEQVKDADVLLVRSVTKVNQALLSLNTNLKFVGSATIGTDHIDQSYLASQGIPFTNAPGCNATAVGEFAFIAMLELAKRFDTELKGKVVGIVGAGNTGSAVAKCLEAYGVEVLLNDPLIEADDPRTFVSLEALTERADVISLHVPLTKDGAHKTWYLFDEQRLQNLKPDTWLLNCCRGEVIDNRALIKIKAQRPDIKLVLDVWEGEPEPMLELVPFVELATPHIAGYSLEGKARGTYMLYQKLMAVLGIDADKSMTSLLPTLWSQQVSLDELPSEKALLQLSRFVYDLRDDDELFRKTLLDDSSIKAGENSANNNGFDLMRKNHKHRREFSALKLASAGQSDVDWLLNLGFSGVGR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DVE1_CAEEL
Sequence: MFPMRVIVETVRSQHCLTCSNEGHMITDTYAIVAGTTTLNQLVETVLAALGHSSMSTSARGLIQVNNWKPLPFDQITENLDDTVENLFKDISSHVVLKILSKPSTDSNSVQCISEVKNKLLKAAVNKNPNVLTNVDNQQVKDVINTIIAGDETLLNSEQIGAVNEWLDTLETNEDRRSPTQVQRFNTLYEIPRLDKWFKSDANPSKQKMNNYLSQLNQSPFRKNNSKISYQQICNWFTQKRSSSRTLAPVDLVQVSSAQTAAQLLPGFQLNLLQSLFGEQRQKFDFYDKLDETKIVGGSDSPSPADDEIHSNSDETIQDTLFSINIKPEPEIDSIASSPDMANSMRESLSSTSPKLLSGLDLGAFSTHSSSTNSMQNANSSVFSAARSRLMFDPLTELPVLEKWFEENPHPTWMQIDQYTQCLNNCAYRENYPHISQHNVKIWFKNRRAKCKRLLNGMQEKLEQKVFV
What is the function of this protein?
Transcription factor (PubMed:35021096).  Acts during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR) (PubMed:17925224, PubMed:30642431).  Required during mitochondrial stress for the activation of genes involved in the mtUPR, in concert with histone deacetylase hda-1 (PubMed:32934238).  In response to the citrate-induced mtUPR, positively regulates transcription of transcription factor nhr-80, thereby leading to modulation of lipid metabolism (PubMed:35021096).  May play a role in modulating the decline in protein homeostasis associated with normal aging (PubMed:32934238).  Required for embryonic development and maintenance of mitochondrial morphology (PubMed:17925224).
What are the official names of this protein?
Homeobox protein dve-1, Defective proventriculus homolog protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Note=Upon mitochondrial stress translocates from cytosol into the nucleus.
Protein: YQGF_STACT
Sequence: MLTHKIIGLDVGSKTVGVAVSDLMGWTAQGLDTLRINEEENELGITKLAEIIKKEDADTVVIGLPKNMNNSIGFRGEASLKYKEELLKILPDINVVMWDERLSTMAAERSLLEADVSRSKRKKVIDKMAAVFILQGYLDSLQ
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMAD4_MOUSE
Sequence: MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPAESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPVVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
What is the function of this protein?
Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor).  Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling.  Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription.  Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta.  May act as a tumor suppressor.  Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).  Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343).  Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343).  In muscle physiology, plays a central role in the balance between atrophy and hypertrophy.  When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4.  MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8.
What are the official names of this protein?
Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, Deletion target in pancreatic carcinoma 4 homolog, SMAD family member 4, SMAD 4, Smad4.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation.
Protein: RS16_ONYPE
Sequence: MAIKMRLQRFGVHKRPFYRVVASESKNARDGKFLEILGTYDTILDIVELDHNKVQKWLSNGAQPTKTVKKVFKKSKFVAKTNTKVEK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: IHFA_ACTP7
Sequence: MALTKIELAESLVEKCGFDKRIAKLFVEQFFEEIRSSLEKGEEVKLSGFGNFSLREKNARPGRNPKTGETVAVTARRVVVFKPGQKLRDRVENVKVKA
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: TGT_ACIAC
Sequence: MLQFELLATDPASHARRGTLTLNHGVVQTPIFMPVGTYGTVKGVMPRSLHEMGAQIILSNTFHLWMRPGLDVMQSFGGLHGFEQWNKPILTDSGGFQVWSLGAMRKITEEGVHFASPVNGDKLFMSPEVSMQIQTVLNSDIVMQLDECTPYETKGHKTTEAEARKSMEMSLRWARRSQDEFHRLGNPNALFGIVQGGMYKNLRQESLERLVEMDFPGYAVGGVSVGEPKDEMLDIMAHTPHRLPAHKPRYLMGVGTPEDLVQGVADGVDMFDCVMPTRNARNGTIFTRFGDLKIRNARHKADHQPLDPTCTCHACAGTEGVAWADGGRGGFSRAYLHHLDRCGEMLGPMLTTVHNLHYYLNLMREIRESLDAGRFGEFRARFAADRAQGV
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PRIM_HCMVA
Sequence: MTLVLFATEYDSAHIVANVLSQTPTDHCVFPLLVKHQVSRRVYFCLQTQKCSDSRRVAPVFAVNNETLQLSRYLAARQPIPLSALIASLDEAETQPLYRHLFRTPVLSPEHGGEVREFKHLVYFHHAAVLRHLNQVFLCPTSPSWFISVFGHTEGQVLLTMAYYLFEGQYSTISTVEEYVRSFCTRDLGTIIPTHASMGEFARLLLGSPFRQRVSAFVAYAVARNRRDYTELEQVDTQINAFRERARLPDTVCVHYVYLAYRTALARARLLEYRRVVAYDADAAPEAQCTREPGFLGRRLSTELLDVMQKYFSLDNFLHDYVETHLLRLDESPHSATSPHGLGLAGYGGRIDGTHLAGFFGTSTQLARQLERINTLSESVFSPLERSLSGLLRLCASLRTAQTYTTGTLTRYSQRRYLLPEPALAPLLERPLPVYRVHLPNDQHVFCAVASETWHRSLFPRDLLRHVPDSRFSDEALTETVWLHDDDVASTSPETQFYYTRHEVFNERLPVFNFVADFDLRLRDGVSGLARHTVFELCRGLRRVWMTVWASLFGYTHPDRHPVYFFKSACPPNSVPVDAAGAPFDDDDYLDYRDERDTEEDEDGKEDKNNVPDNGVFQKTTSSVDTSPPYCRCKGKLGLRIITPFPACTVAVHPSVLRAVAQVLNHAVCLDAELHTLLDPISHPESSLDTGIYHHGRSVRLPYMYKMDQDDGYFMHRRLLPLFIVPDAYREHPLGFVRAQLDLRNLLHHHPPHDLPALPLSPPPRVILSVRDKICPSTEANFIETRSLNVTRYRRRGLTEVLAYHLYGGDGATAAAISDTDLQRLVVTRVWPPLLEHLTQHYEPHVSEQFTAPHVLLFQPHGACCVAVKRRDGARTRDFRCLNYTHRNPQETVQVFIDLRTEHSYALWASLWSRCFTKKCHSNAKNVHISIKIRPPDAPVPPATAV
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Protein: FBXW8_MOUSE
Sequence: MDDHNLEEFRRHWQEELAQSQALRRRRRLEAGERRSPRRPEAGARGEPASGYLGLAQGLLEGAGRPPAPRPGRGGDRKDTSSRSRSPPDRDATEPEPLVDQLIRDLNELDDVPFFDVRLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCRQEGHLPHSRFSDYTCWKLILQECLAKEHTLRANWKNRKGAVSELEHVPDAVLCDVRSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESESEEEDPGMQPYVSFVRINSSLAVAAYEDGILNIWDLRTGRFPIFRFEHDARIQALALSQEKPIVATASAFDVVMLYPNEEGHWHVASEFEVQKLVDYLEIVPNTGRYPVAIATAGDLVYLLKADDSARTLHYVYGQPATCLDVSASQVAFGVKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNIRDSPPNLMVSGNMDRRVRIHDLRSDKIALSLSAHQLGVSAVQMDDWKVVSGGEEGLVSVWDYRMNQKLWEVHSRHPVRYLSFNSHSLITANVPYEKVLRNSDLDNFACHRRHRGLIHAYEFAVDQLAFQSPLPVCRLPRDIMAGYSYDLALSFPHDSI
What is the function of this protein?
Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain.  The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation.  Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity).
What are the official names of this protein?
F-box/WD repeat-containing protein 8, F-box and WD-40 domain-containing protein 8.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons.
Protein: GPSB_OCEIH
Sequence: MSVNRIQLSGKDILEKDFKTGIRGYSQEEVDEFLDVIIQDYDNFKQEIDRLKAENEKLKKSTPAVEQSRSRSQQPPTSQVNYDVLKRLSNLEKAVFGKRYTEQEES
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: ENO_XYLFA
Sequence: MTAIAKIYAREILDSRGNPTLEAEVTLENAVCGRAAVPSGASTGTKEAVELRDGDKTRYLGKGVRAAVDNVNGVIAAALVGFDGADQTGLDHRLINLDGTENKGRLGANALLGVSLATAHAVAAARKQPLWMYLSTLGESKVSLPVPMMNIINGGAHADNNVDFQEFMVLPVGFASFSEALRAGTEIFHALKSVLKGQGLSTAVGDEGGFAPDLRSNVEALDAILEAIGRAGYIAGEDVLLGLDVASSEFRDNGKYNLVGENKRLTSEQFVDFLDDWVTQYPIISIEDGLAEDDWAGWKQLTERIGHKVQLVGDDLFVTNPKVFQEGITSGIANAILIKLNQIGTLTETLESIAMAHRAQYAAIVSHRSGETEDTSIADIAVATTATQIKTGSLCRSDRVAKYNQLLRIEQALGVGARYAGRDAFVSLKS
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: FM25C_MOUSE
Sequence: MLGGLGKLAAEGLAHRTEKATEGAVHAVEEVVSEVVGHAKEVGEKAINDALKKAQESGDRVVKEVTEKVTHTITDAVTHAAEGLGRLGQ
What are the official names of this protein?
Protein FAM25C.
What is the protein family that this protein belongs to?
Belongs to the FAM25 family.