PharMolix/UniProtQA huggingface dataset:
Protein: RLMN_GEOUR
Sequence: MEKVDIKNFTLQELEAYIAGQGKERFRAKQIFKWLYQQDAREFADMTNLSKDFRQELEKTAWISNLDAEAVEASADGTKKYLFRLADGNAVESVLIPDEDRTTLCISSQVGCAMGCEFCLTGTFKLTRNLTTAEIVNQVCAVKRQEPVRNIVFMGMGEPLANLKNVVGALKILTDPDGFQFSTRKVTVSTSGLVPEMAELGASVTVNLAVSLNATTDEVRDRIMPINRRYPLKELLAACKAFPLPSRRWITIEYVMIRGVNDSLDDAKRLVRLISNIPSKVNLIPFNEHDGCTFQAPTQDSIDKFHKFLLDKHVTVITRSSRGSDISAACGQLKGRLDKAVKD
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWR1_CANAL
Sequence: MPENGRLRRTSARLTQNGTSTSSSTIYQNGKRTSQHAQETSTASNKKRKVSTQSKEDKLSDIIVDFNLAVNELYQLKEYKSIISWDPIENSSANDRGIKAEFEEFVKNNDYRLVWDKEIENNSNIDSLPLRFQKKKLAEQNKLLDDKFSIRQNVLASSKMLEESLVNKTRDEVKIESTFKAIQSQEKAGSKLKTPSQTSNAKTNIRKSGSTTPKRGNENGSRKQALEDQDEIIELSDDSSVVEIESDLSDAETHYRIKCIKKTVPPPLVTHPSHIPQWRPENLEDGNRSTGRLIQLKDSSSSSKIINFDPTPLEIIQLKDEVIAAPKLTEKLQNFLNNDFKTPIIDESNVPDYNFTRDEYNTIMSQQEKLLRKLYHKVNIENSLELNGDKIERRKVILPQSNIKLTDPFRNTFSVKPKLHGAANNATHQDYLLAQGMAFSKVHQQMRKQHHLRTRKIAAMIDQHFKKKKGEKERLAKEREQNLKKMSRLTMQAVKKRWNQAQKVYQIIQNEKEEELKKIKGRQHLSEMLEHSTQLLEAQLTSSREPTVEAESDDNSTTFDDNTNDSDNFSSSEEEENEEDNTQQQINGNKKYDVNGKSNDENDMSLSVEELRKKYADLETSVEPLSSNVTSDKERESETSSEDAESSDDDDTDVTRGLASLYQNDEVADFATTTFEYSAEEKKLIEDLNQESDSRMNSLLDSDSVSSISDSESSEESSSDTEMDQSNVSEPPRSSETGSNTGLASLFTNGTIVSDEEDDASISSNFENESDESMNSSDRELEVNGNGKIDKIASTDEDDSNVEIVNGSKVKDVPIPSLLRGTLRPYQKQGLNWLASLYNNNTNGILADEMGLGKTIQTISLLAYLACEHHKWGPHLIIVPTSVMLNWEMEFKKFAPGFKVLTYYGSPQQRAQKRKGWNKPDAFHVCITSYQLVVQDQQSFKRRRWTYMILDEAHNIKNFRSTRWRALLNFNTENRLLLTGTPLQNNLMELWSLLYFLMPSSKVNQAMPEGFANLDDFQQWFGKPVDRILEQTSAGNSDLIDENERTTQKMDEETRNTVARLHQVLRPYLLRRLKKDVEKQMPGKYEHIVYCRLSKRQRFLYDDFMSRAKTKETLASGNFLSIINCLMQLRKVCNHPDLFEVRPIVTSFAMPRSIPSYYQSTNELVKRQFNKDEKVSFQALNLDVTGCENMNYFVCQSTGKLMTTEPFQDQINKLKILLVEFENSDPINYVSYYQRLRREEQAEIKEKLEHVVYLNNLRCGRKPIYGESLLRLLTVNAHDFSDEPYNKYCLTLSGRVDKMNDTIEKYSIITPAAVALDMKDQLIPISTKQRILHEVAENKIDNPFHKAQVKLSIAFPDKTLLQYDCGKLQKLATLLQELTSQGHRALIFTQMTKVLDILEQFLNIHGYRYMRLDGATKIEDRQLLTEKFNRDPKIPVFILSTRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQVRDVHIYRFVSEYTIESNIIKKANQKRQLDNVVIQEGEFTTDYFGKFSVRDLVSDSNIGKEITDRTIDFSGDAKMGNVLAQAEDEEDRVAAGAALKEVAIDDDDFKEETRSATTGATPAPTETNALSTTDGDAAFIDVDYEDGIGHIDEYMLRFISDGYYL
What is the function of this protein?
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
What are the official names of this protein?
Helicase SWR1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAH1_LOTGI
Sequence: MKLQGAGCVVAAVLGALFIVNVESHFHKPELQLCKAFGEPCISYDVRSTIGPRCWFKLEFPREKCCNENGKRQSPIDIPDVKSIYKVPQKLRYSSRKFVGHLENTGIQPAFKRKVGADKVYLEGIGSPVGKRYFIENVHFHVGVRHKERQTENTLNGRSFDGEAHIVHIREDFGDLKEAANHPQGLLVISIFLSTSKGERRRDGFDDLIEMIQDVQEFEEEDGPCANVKIPDIFKFKQLIPFHPVWPICKKTFPVADDSDNSGSGVVCNFYLPNGLCGEKKESKINPNELLADDPEYYVFNGGLTTPPCSESVLWLVAKQPRKVSVFYPYVVRNMETQREGEIIGDFGNLRPLQDLNDRPVFLVRFRLKRNWEHGDTAANDNDAMDSPFSVLGIN
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Putative carbonic anhydrase 1, Putative carbonate dehydratase 1.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Secreted.
Protein: PG16_MYCTU
Sequence: MSFVVTAPPVLASAASDLGGIASMISEANAMAAVRTTALAPAAADEVSAAIAALFSSYARDYQTLSVQVTAFHVQFAQTLTNAGQLYAVVDVGNGVLLKTEQQVLGVINAPTQTLVGRPLIGDGTHGAPGTGQNGGAGGILWGNGGNGGSGAPGQPGGRGGDAGLFGHGGHGGVGGPGIAGAAGTAGLPGGNGANGGSGGIGGAGGAGGNGGLLFGNGGAGGQGGSGGLGGSGGTGGAGMAAGPAGGTGGIGGIGGIGGAGGVGGHGSALFGHGGINGDGGTGGMGGQGGAGGNGWAAEGITVGIGEQGGQGGDGGAGGAGGIGGSAGGIGGSQGAGGHGGDGGQGGAGGSGGVGGGGAGAGGDGGAGGIGGTGGNGSIGGAAGNGGNGGRGGAGGMATAGSDGGNGGGGGNGGVGVGSAGGAGGTGGDGGAAGAGGAPGHGYFQQPAPQGLPIGTGGTGGEGGAGGAGGDGGQGDIGFDGGRGGDGGPGGGGGAGGDGSGTFNAQANNGGDGGAGGVGGAGGTGGTGGVGADGGRGGDSGRGGDGGNAGHGGAAQFSGRGAYGGEGGSGGAGGNAGGAGTGGTAGSGGAGGFGGNGADGGNGGNGGNGGFGGINGTFGTNGAGGTGGLGTLLGGHNGNIGLNGATGGIGSTTLTNATVPLQLVNTTEPVVFISLNGGQMVPVLLDTGSTGLVMDSQFLTQNFGPVIGTGTAGYAGGLTYNYNTYSTTVDFGNGLLTLPTSVNVVTSSSPGTLGNFLSRSGAVGVLGIGPNNGFPGTSSIVTAMPGLLNNGVLIDESAGILQFGPNTLTGGITISGAPISTVAVQIDNGPLQQAPVMFDSGGINGTIPSALASLPSGGFVPAGTTISVYTSDGQTLLYSYTTTATNTPFVTSGGVMNTGHVPFAQQPIYVSYSPTAIGTTTFN
What are the official names of this protein?
PE-PGRS family protein PE_PGRS16.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PE family. PGRS subfamily.
What are the subcellular locations of this protein?
Cell surface.
Protein: RS16_BRUSI
Sequence: MALKIRLARAGSKKRPYYHVVVADVRAPRDGRFIETVGSWNPVLLKDAERVKLDAERIQHWIAQGAQPTDRVLRFLDQAGIAKRPSRNNPTKGEPGKKAQERLALAKQAEEEAAAKAAEAAAAAAAPAEEAASE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: NNRE_DANRE
Sequence: MLGVRALFGIGLLVTSRGGFVLTHTRACSSAASNIYSKHLTHRPTCTMANTGVKYLGQEEAQQIDEELFSDFSFSVDQLMELAGLSCATAVAKGYPVTSLLKSPARVLVICGPGNNGGDGLVCARHLKLFGYEPSVLYPKRPNKQLFQNLSIQCQKMEIPFLTEMPEADLIDEAYSLVVDAIFGFSFKGAVREPFGEILSQLKKITVPIASVDIPSGWDVEKGCPDGIQPDMLISLTAPKKSAALFKGRFHFLGGRFVPPVLEQKYQLNLPQYPGTECVFQLN
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, Apolipoprotein A-I-binding protein, AI-BP, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
What are the subcellular locations of this protein?
Mitochondrion. Secreted.
Protein: YAFD_SALTY
Sequence: MRKNTYAMRYVAGQPAERILPPGSFASIGQALPAGEPLSNEERIRILVWNIFKQQRAEWLSVLKNYGKDAHLVLLQEAQTTPELVQFATANYLAADQVPAFVLPQHPSGVMTLSAAHPVYCCPLREREPILRLAKSALVTVYPLPDTRLLMVVNVHAVNFSLGVDVYSKQLLPIGDQIAHHSGPVIMAGDFNAWSRPRMNALYRFAREMSLRQVRFTDDQRRRAFGRPLDFVFYRGLNVNEASVLVTRASDHNPLLVEFSPGKPEQ
What are the official names of this protein?
UPF0294 protein YafD.
What is the protein family that this protein belongs to?
Belongs to the UPF0294 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL333_STAAT
Sequence: MRVNVTLACTECGDRNYITTKNKRNNPERVEMKKFCSRENKQTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 3.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: SRF_CAEEL
Sequence: MTEAEDFAQLLQKLQNASPALPEGTSSTPTPSSSTGLLPNGKKTKGRVKIKMEYINNKLRRYTTFSKRKTGIMKKAFELSTLTGTQVMLLVASETGHVYTYATPKLQPMISSDTGKAMIQSCLNAPGGDGSDVQPSRTEFTFDSGNGGNGMRKRKMLSDVMSAESSNNSPSMPNFTPFLAPSMAPLFSTFGEDDYNNDESGDDSDSEEASSDIKEEYQGSPTMVKQETTEIDSVTASLQQRIKEAMRQAASNKQAIKKAKITPPSSNMNNAAFLNPFLLQGGANASNLLATAARKGDDAGSLTSNPFLSMGLNLQQLIESAAIASNE
What is the function of this protein?
Transcription factor (By similarity).  Regulates myogenesis, in cooperation with transcription factors hlh-1 and hnd-1 (PubMed:15892873, PubMed:17142668).  Required for maintenance of muscle in adulthood (PubMed:29314608).
What are the official names of this protein?
Serum response factor homolog, Uncoordinated protein 120.
What are the subcellular locations of this protein?
Nucleus.
Protein: S35F3_MOUSE
Sequence: MKKHSARVAPLSACNSPVLTLTKVEGEERPREPPGPAEAQAPAGTEAGGRTSRHNWTCSQERLKKVFWGVAVVFCVCASWAGSTQLARLTFKTFDAPFTLTWFATNWNFLFFPLYYAGHVCKSTEKQSMKQRYRECCRFFGDNGLTLKVFFTKAAPFGVLWTLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSVIGIALVVGSASMSALYKVLFKLLLGSAKFGEAALFLSILGVFNILFITCIPVILYFTRVEYWNSFDDIPWGNLCGFSILLLTFNIVLNFGIAVTYPTLMSLGIVLSVPVNAVVDHYTSQIVFNGVRVIAIIIIGLGFLLLLLPEEWDVWLIKLLTRLKVRKKEETAESSGDLGTGPQSRSRRARPSFAR
What is the function of this protein?
Mediates thiamine transport.
What are the official names of this protein?
Solute carrier family 35 member F3, Thiamine transporter SLC35F3.
What is the protein family that this protein belongs to?
Belongs to the SLC35F solute transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SERC_PROMH
Sequence: MSQVYNFSAGPAMLPAEVLRRAELELCNWHGLGRSVMEISHRSKEFLEVAHQAEQDLRDLLNVPENYKILFCHGGARGHFAALPLNLLGEKTTADYIDGGYWAKSAADEAEKYCSPNIIKIKTEIDGKIAVKPMKEWQLSDNAAYVHYCPNETIDGIAIHEEPDFDDKKIVIADYSSAILSQPLDVSRFGMIYAGAQKNIGPAGLTLVIIREDLLGKARKETPSVFDYTVLAENDSMFNTPPTFAWYLSGMVFKWLKEQGGLQEIAKRNYEKATLLYSAIDNSDFYINRIATENRSLMNVPFQMSSPALDAVFLKEAEEQGLVALKGHRVSGGMRASIYNAMPFAGVQALVDFMADFERRHA
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEJL_ECOLU
Sequence: MPQISRYSDEQVEQLLAELLNVLEKHKAPTDLSLMVLGNMVTNLINTSIAPAQRQAIANSFARALQSSINEDKAH
What are the official names of this protein?
UPF0352 protein YejL.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: ORYQ_ASPOR
Sequence: MRLWPAIAISLPRVTPPEGCEIDGSWVPGGTKVGVSQWSAYRSERNFARADQFLPERWLPEGEEESFINDTRAAFQPFSTGPRNCLGMNFARAETRIIFARLLLDFDLELLTGRDEWEAQKVYIIWDRCPLYVRGFGRQTRHKRPANLWLPWDTHGSSASNERKLADLLS
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of oryzines, natural products with an unusual maleidride backbone (PubMed:30104550).  The two subunits of the fungal fatty acid synthase oryfasA and oryfasB probably form octenoic acid (Probable).  This fatty acid is most likely activated by the acyl-CoA ligase oryP to give octenyl-CoA before the citrate synthase-like protein oryE catalyzes condensation with oxaloacetate to form tricarboxylic acid (Probable).  The next steps of the pathways are conjectural, but a favorite possible route has been proposed, beginning with decarboxylation and concomitant dehydration by the decarboxylase oryM, followed by tautomerization, which may lead to the production of a diene intermediate (Probable).  Reduction of this diene intermediate could give the known metabolite piliformic acid (Probable).  On the pathway to oryzine B and oryzine A, however, hydroxylation of the diene by the alpha-ketoglutarate-dependent dioxygenase oryG and lactonisation by the lactonohydrolases oryH or oryL could give oryzine B directly (Probable).  Finally, enoyl reduction by the dehydrogenase oryD would then convert oryzine B into oryzine A (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase oryQ, Oryzines biosynthesis cluster protein Q.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: OBG_SHEB2
Sequence: MKFVDEAVIRVEAGDGGSGCVSFRREKYVPDGGPDGGDGGDGGSVFLQADENFNTLIEFRFERFHMAERGENGRGRDCTGHSGKDLILKVPVGTRAVDHDTEEVLGDLTTHGQKLLVAKGGFHGLGNTRFKSSTNRAPRQKTLGTPGEVRSLKLELLLLADVGLLGMPNAGKSTFIRAVSRATPKVADYPFTTLVPNLGVVNPRPGQSFVIADIPGLIEGAADGAGLGIRFLKHLERCRILLHIIDIEPIDGTDPVESARAIVGELEKYSPKLASKPRWLVFNKTDLLLEEELQQKVDRIVKEMGWEGDVYTISAYNRDGTNELALKLLDYIASLPPEDNEIDPDSEVEFKWDNYHQANLDSVNEDYVDEDDDDDFDDDDYDVEVIYQR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_CERS4
Sequence: MTRDPIATARTLSEALPYLQRYAGAVVVVKFGGNAMGDEAAMAEFARDIVLMRQVGVNPVVVHGGGPMINELLGKLGIKSEFVRGKRVTDKATVEVVEMVLSGLVNKRIVQAINDQGGRAVGISGKDDDLMVCVADDPDLGFVGKPVEMNVQVLRDLYNAGIIPVVAPVATGMADNETFNVNGDTAAGAIAGALQADRLLLLTDVAGVKDASGEVLSQLTPSQVREMVASGTISGGMIPKTETALAALDEGVRAVVILDGRTPNACLIEIFTDEGAGTIIRSTEPRVKPRVRR
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBAN_ECOLI
Sequence: MQRIILIIIGWLAVVLGTLGVVLPVLPTTPFILLAAWCFARSSPRFHAWLLYRSWFGSYLRFWQKHHAMPRGVKPRAILLILLTFAISLWFVQMPWVRIMLLVILACLLFYMWRIPVIDEKQEKH
What are the official names of this protein?
Inner membrane protein YbaN.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VG08_BPP22
Sequence: MEPTTEIQATEDLTLSGDHAAASADSLVVDNANDNAGQEEGFEIVLKDDETAPKQDPAKNAEFARRRIERKRQRELEQQMEAVKRGELPESLRVNPDLPPQPDINAYLSEEGLAKYDYDNSRALAAFNAANTEWLMKAQDARSNAVAEQGRKTQEFTQQSAQYVEAARKHYDAAEKLNIPDYQEKEDAFMQLVPPAVGADIMRLFPEKSAALMYHLGANPEKARQLLAMDGQSALIELTRLSERLTLKPRGKQISSAPPADQPITGDVSAANKDAIRKQMDAAASKGDVETYRKLKAKLKGIR
What is the function of this protein?
Required for successful condensation of DNA within the capsid.  The interior of the prohead is filled with the gp8 protein.  The scaffolding protein is lost from the structure during packaging.
What are the official names of this protein?
Scaffolding protein, Protein gp8.
Protein: LEC2_CYMRO
Sequence: SGAVHFSFTKFSTSSSDLTLQGSALVSSKGSLKKNPSKKGKPVDHSVGRALYRSPIHIWDETTGKVASFDATFSFVSEAPAIPMLFPSSKGELNDEDDTRIGGQLGVVNDSYNVIRVTVAVENDGYRNRVDPSARPHISLPIKSVRSKKTAKWNMQTGKVGTAHISYNSVAKRLSAVVSYTGNSSSTTVSYDVLLNLAVLPSKVLVGKTATGLYKDHVETNTILSWSFTSKLKTNSIAD
What is the function of this protein?
Lactose-binding lectin.  Also binds derivatives of galactose, glucose, lactose, and mannose.  Binds O-glycoproteins such as mucins more strongly than N-glycoproteins.  Shows agglutinating activity towards rabbit erythrocytes.
What are the official names of this protein?
Lactose-binding lectin-2, Lectin-II, CRLII.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
What are the subcellular locations of this protein?
Vacuole, aleurone grain. Vacuole. Note=Cotyledonary membrane-bound vacuolar protein bodies.
Protein: HILA_PANAA
Sequence: MTDLLTLEPTQTILTGSKKTNFGYLESTDGVINFSIVKNIILNGHHHGNVLYVIRNYASKAVCEKLAKNFDYRVTQSGGNRADDGFVLTNQIGATQFSRNGEQYIHEVNRVNQSVADLMKATSAEDSESLFLNLTLEKEFLERGIHFGPARFKNGYACFATFRRWLDNGVMSLMPHEDMAQVDFAKEDGFEIANTQTVTAYNVCLEAAQGGGQLKIWNLIPDQVCRETLGVTRTGYPYPPHLLNETESLSVQLNAGDLYFMNACHLHGVSSVSEGSRLTAGRFIGKLNDRKVVYWT
What is the function of this protein?
Catalyzes the hydroxylation of L-isoleucine at the C-4' position to form L-4'-hydroxyisoleucine (4'-HIL) (PubMed:23554367).  Exhibits low activity with L-valine and L-methionine (PubMed:23554367).
What are the official names of this protein?
L-isoleucine 3(1)-dioxygenase, L-isoleucine 4'-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: SPEE_CLOB8
Sequence: MELWYTEQHTENVRFSIKVEKEIHTEKTEFQRIDVLEAKEFGRFFTLDGLMMVTEKDEFIYHDMIVHVPMATNPNIKNVLVIGAGDGGTIRELTRYSTVEKIDMVEIDKRVVDICREYFPLTSCKLDDKRVNVFYEDGLKFIRDKEDEYDLIIVDSTDPFGPGEGLFTKEFYGNCYKALREDGILVNQHESPYYDNDAAAMKEAHEKITKFFPIIRVYQAHIPTYPSGHWLFGFASKKYHPIKDFDAEAWNKLGIKTKYYNTDLHVGCFALPTYVRDMLNGLTD
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1695_HAEIN
Sequence: MKFSVLMSLYIKENPQFLRECFESLVAQTRQADEIVLVFDGVVTPDLEFVVTEFETKLPLKLVKLPQNRGLGKALNEGLLHCDYDWVFRMDTDDICVPDRFEKQVAFIEQHPESIIFGGQIAEFGKNVNDIVAYRNVPTSAQEIIKFTQKRCPFNHMTVAYQKSAVINCGGYEDLQEDYYLWIKLVAQGLYMANLPDILVYARVGNGMVSRRRGVNQAKAEWRLFKLKYRLGIQGLLSGLFTFALRFGSRLLPTSLLKKLYQTFLRK
What are the official names of this protein?
Uncharacterized glycosyltransferase HI_1695.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: FABH_ENTFA
Sequence: MKNYARISCTSRYVPENCVTNHQLSEMMDTSDEWIHSRTGISERRIVTQENTSDLCHQVAKQLLEKSGKQASEIDFILVATVTPDFNMPSVACQVQGAIGATEAFAFDISAACSGFVYALSMAEKLVLSGRYQTGLVIGGETFSKMLDWTDRSTAVLFGDGAAGVLIEAAETPHFLNEKLQADGQRWAALTSGYTINESPFYQGHKQASKTLQMEGRSIFDFAIKDVSQNILSLVTDETVDYLLLHQANVRIIDKIARKTKISREKFLTNMDKYGNTSAASIPILLDEAVENGTLILGSQQRVVLTGFGGGLTWGSLLLTL
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIM1_DROME
Sequence: MPKVTKEKKSRIHNDVQKQGIVFNKDFGQHILKNPLVITTMLEKAALRATDVVLEIGPGTGNMTVRMLERAKKVIACEIDTRLAAELQKRVQATPLQPKLQVLIGDFLKAELPFFDLCIANVPYQISSPLIFKLLLHRPLFRCAVLMFQREFAERLVAKPGDKLYCRLSINTQLLARVDMLMKVGKNNFRPPPKVESSVVRLEPKNPPPPVNFTEWDGLTRIAFLRKNKTLAATFKVTSVLEMLEKNYKLYRSLRNEPIEDDFKMQDKVISILEEQDMAAKRARSMDIDDFMRLLLAFNSAGIHFN
What is the function of this protein?
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.  Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
Probable dimethyladenosine transferase, Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase, Probable 18S rRNA dimethylase, Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: X_HBVB2
Sequence: MAARLCCQLDPARDVLCLRPVGAESRGRPLPGPLGALPPASPPAVPSDHGAHLSLRGLPVCAFSSAGPCALRFTSARRMETTVNAHRNLPKVLHKRTLGLSAMSTTDLEAHFKDCVFTEWEELGEEIRLKVFVLGGCRHKLVCSPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: MSCL_ACTSZ
Sequence: MSFIKEFREFAMRGNVVDMAVGVIIGGAFGKIVSSLVGDVVMPVLGILTGGVDFKDMKMVLAEAVGETPAVTLNYGMFIQNVFDFIIIAFAIFLMIKAINKLKKPAEEAPKGPSQEELLAEIRDLLKK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MAP2_BOVIN
Sequence: MAGVEEAASCGSHLNGDLDPDEREEGAASTAEEAAKKKKRKKKKSKGAATGQQEPDKEAGASVDEVTRQLERQALEEKEKDDDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKMEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
What is the function of this protein?
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR.  Plays a critical role in the regulation of protein synthesis.
What are the official names of this protein?
Methionine aminopeptidase 2, MAP 2, MetAP 2, Initiation factor 2-associated 67 kDa glycoprotein, p67, p67eIF2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes.