PharMolix/UniProtQA huggingface dataset:
Protein: QRIC1_HUMAN
Sequence: MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQVQVQQSPQQVSAQLSPQLTVHQPTEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQQQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTPQEQTPPPQQQQQQLQVTCSAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDKSTSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAIAVANASTMH
What is the function of this protein?
Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352).  Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352).  ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352).  May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352).  Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress.  Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352).  Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).
What are the official names of this protein?
Transcriptional regulator QRICH1, Glutamine-rich protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane.
Protein: ARLY_CHLL2
Sequence: MFFMSNKKELLWQSRFSEPFDRDALRFSSSVHVDKALFREDIEGSTAHVTMLAEEGIISEEESGQIIRGLREIGAELEAGDLVPHWEDEDIHTVIENRLKEKIGATAGKIHSGRSRNDQVATDTRLYLRRQIRTLGTALQGLQKTLVSKAETYRETIIFGYTHLQRAQPISAGHYYLAYFNMFRRDRDRLTDLLKRVNISPLGAAAFAGSTLPLNPARSAELLDFDGVFSNSIDAVSDRDTVIEFISVCSMVMMHLSRFAEDLILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELVRGKTGRVYGSLITMLTIMKGLPLSYNRDMQEDKPPLFDTAETTIESVSIFGKLLEHTTLKEERLAKLTADDLSLATEIAEYLVKKQLPFRDAHRVTGRIVSHSLMSGTTLPGITLDVYRTFSELFESDIYAALKPEASIKAKKTHGSCSFDSVAIQLEEAKKLL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_AGRFC
Sequence: MIQMQTNLDVADNSGARRVMCIKVLGGSKRKYASVGDIIVVSIKEAIPRGRVKKGDVMKAVVVRTAKDIRRADGSVIRFDNNAAVLIDNKKEPIGTRIFGPVPRELRAKNHMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SRP19_PYRIL
Sequence: MKKRGGRILWLVYLDSSVPRSRGRILPRSKAVSKPTLQEVIQALERLGYRYQVYQDKKYPALWFEERQGYIVVETSEKLRILALKVAEEVRKLRR
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBB9_ARATH
Sequence: MREILHIQGGQCGNQIGAKFWEVICGEHGIDQTGQSCGDTDLQLERINVYFNEASGGKYVPRAVLMDLEPGTMDSLRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMMTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLANPTFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYSALSVPELTQQMWDAKNMMCAADPRHGRYLTASAVFRGKMSTKEVDEQMMNVQNKNSSYFVEWIPNNVKSSVCDIAPTGLKMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVAEYQQYQDATVGEEEYEEDEEEEEA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-9 chain, Beta-9-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL15E_METMA
Sequence: MVKSFYGYVRDAWKNPDETYVNELRWERLQVWRKQGSVTRIERPTRIDRARSLGYKAKQGIVVVRVNVRRGGLGHVRPNRGRRTQKMGKNKVSGGMSIQRIAEARADRKYPNLEVLNSYWVGEDGKHKWFEVILVDPHHPVIKSDKNLNWICDASIRGRATRGKTSAGRKGRGMSTRGKGTEKTRPSIRAHKSRGK
What are the official names of this protein?
50S ribosomal protein L15e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: DABA_STAAS
Sequence: MTTQLNINSVIENAKRVITPLSPISIFAARNPWEGLEADTFEDVAKWLRDVRDVDIFPNKALIESAVARGELDESVFNQLVTDMLLEHHYNIPQHYINLYIDNIKTLKDVPASYMNHSNVDVVADLLLEKSKRDMADSYHHYDVRPMSDAIIDEQGEPLSEQVNRQMIKWTKLYIDQFLSSWTMPKREQSFYHAWLHLAQHDHSFTKAQRQVIKGLPNDPKMTIESVLTHFSIDQEDYQAYVEGHLLALPGWAGMLYYRSQQHHFEQHLLTDYLAIRLVVEQLLVGDEFKSVTKDCESRSENWFKQTVASWCYYSDMPSDVLLQHDVNEIQTFIHFAATMNKNVFKNLWLIAWEMTYESQLKQKIKAGHESVAGALDVNQVNVSENDNANQPHSVLLNDTQAVDENNSELNQVGTSTKAQIAFCIDVRSEPFRRHIEAAGPFETIGIAGFFGLPIQKDAVDEQFKHDSLPVMVPPAYRIKEFADRYDMNVYRQQQQTMSSMFYTFKLMKNNVMPSLLLPELSGPFLSLSTIVNSIMPRKSRASLQKITQKWLKKPETKLTIDREFDRTSDLPVGFTEQEQIDFALQALKLMDLTEAFAPFVVLAGHASHSHNNPHHASLECGACGGASSGFNAKLLAMICNRPNVRQGLKQSGVYIPETTVFAAAEHHTSTDTLAWVYVPDTLSSIALDAYESLNDAMPMISEHANRERLDKLPTIGRVNHPVEEAQRFASDWSEVRPEWGLAKNASFIIGRRQLTKGIDLEGRTFLHNYDWRKDKDGKLLNTIISGPALVAQWINLQYYASTVAPHFYGSGNKATQTVTSGVGVMQGNASDLMYGLSWQSVMAADRTMYHSPIRLLVVVQAPDYVVARLLANNDHFARKVSNHWLRLMSVNEEGRFKSWI
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NU4LM_PLAMN
Sequence: MSLINMNLMLAFTMSLTGLLMYRHHLMSALLCLEGMMLSLFTLTTLTILNTHFTLTNMIPIILLVFAACEAAIGLALLVMISSTYGTDYVQSLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NARZ_ECOLI
Sequence: MSKLLDRFRYFKQKGETFADGHGQVMHSNRDWEDSYRQRWQFDKIVRSTHGVNCTGSCSWKIYVKNGLVTWEIQQTDYPRTRPDLPNHEPRGCPRGASYSWYLYSANRLKYPLIRKRLIELWREALKQHSDPVLAWASIMNDPQKCLSYKQVRGRGGFIRSNWQELNQLIAAANVWTIKTYGPDRVAGFSPIPAMSMVSYAAGTRYLSLLGGTCLSFYDWYCDLPPASPMTWGEQTDVPESADWYNSSYIIAWGSNVPQTRTPDAHFFTEVRYKGTKTIAITPDYSEVAKLCDQWLAPKQGTDSALAMAMGHVILKEFHLDNPSDYFINYCRRYSDMPMLVMLEPRDDGSYVPGRMIRASDLVDGLGESNNPQWKTVAVNTAGELVVPNGSIGFRWGEKGKWNLESIAAGTETELSLTLLGQHDAVAGVAFPYFGGIENPHFRSVKHNPVLVRQLPVKNLTLVDGNTCPVVSVYDLVLANYGLDRGLEDENSAKDYAEIKPYTPAWGEQITGVPRQYIETIAREFADTAHKTHGRSMIILGAGVNHWYHMDMNYRGMINMLIFCGCVGQSGGGWAHYVGQEKLRPQTGWLPLAFALDWNRPPRQMNSTSFFYNHSSQWRYEKVSAQELLSPLADASKYSGHLIDFNVRAERMGWLPSAPQLGRNPLGIKAEADKAGLSPTEFTAQALKSGDLRMACEQPDSSSNHPRNLFVWRSNLLGSSGKGHEYMQKYLLGTESGIQGEELGASDGIKPEEVEWQTAAIEGKLDLLVTLDFRMSSTCLFSDIVLPTATWYEKDDMNTSDMHPFIHPLSAAVDPAWESRSDWEIYKGIAKAFSQVCVGHLGKETDVVLQPLLHDSPAELSQPCEVLDWRKGECDLIPGKTAPNIVAVERDYPATYERFTSLGPLMDKLGNGGKGISWNTQDEIDFLGKLNYTKRDGPAQGRPLIDTAIDASEVILALAPETNGHVAVKAWQALGEITGREHTHLALHKEDEKIRFRDIQAQPRKIISSPTWSGLESDHVSYNAGYTNVHELIPWRTLSGRQQLYQDHPWMRAFGESLVAYRPPIDTRSVSEMRQIPPNGFPEKALNFLTPHQKWGIHSTYSENLLMLTLSRGGPIVWISETDARELTIVDNDWVEVFNANGALTARAVVSQRVPPGMTMMYHAQERIMNIPGSEVTGMRGGIHNSVTRVCPKPTHMIGGYAQLAWGFNYYGTVGSNRDEFIMIRKMKNVNWLDDEGRDQVQEAKK
What is the function of this protein?
The alpha chain is the actual site of nitrate reduction.
What are the official names of this protein?
Respiratory nitrate reductase 2 alpha chain.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TEX55_HUMAN
Sequence: MEEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQLSYYETRGQSEDRIFPQLGNSKEDKEADYRVQPCKFEDSQVDLNSKPSVEMETQNATTIPPYNPVDARFTSNFQAKDQALFPRLPSISSKLNYTSSQEKTQAIVTKSDEFSEIDQGKGYHIRNQTYRRFPSIVYEDPYQVSLQYMEKHHILQIFQQITENLVYEKPEDPLNFMLCQV
What are the official names of this protein?
Testis-specific expressed protein 55, Testis-specific conserved, cAMP-dependent type II PK-anchoring protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: INS_PLATA
Sequence: VAPPQHLCGSHLVDALYLVCGDRGFFYNPKGIVEQCCHRPCNIFDLQNYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AGO10_ARATH
Sequence: MPIRQMKDSSETHLVIKTQPLKHHNPKTVQNGKIPPPSPSPVTVTTPATVTQSQASSPSPPSKNRSRRRNRGGRKSDQGDVCMRPSSRPRKPPPPSQTTSSAVSVATAGEIVAVNHQMQMGVRKNSNFAPRPGFGTLGTKCIVKANHFLADLPTKDLNQYDVTITPEVSSKSVNRAIIAELVRLYKESDLGRRLPAYDGRKSLYTAGELPFTWKEFSVKIVDEDDGIINGPKRERSYKVAIKFVARANMHHLGEFLAGKRADCPQEAVQILDIVLRELSVKRFCPVGRSFFSPDIKTPQRLGEGLESWCGFYQSIRPTQMGLSLNIDMASAAFIEPLPVIEFVAQLLGKDVLSKPLSDSDRVKIKKGLRGVKVEVTHRANVRRKYRVAGLTTQPTRELMFPVDENCTMKSVIEYFQEMYGFTIQHTHLPCLQVGNQKKASYLPMEACKIVEGQRYTKRLNEKQITALLKVTCQRPRDRENDILRTVQHNAYDQDPYAKEFGMNISEKLASVEARILPAPWLKYHENGKEKDCLPQVGQWNMMNKKMINGMTVSRWACVNFSRSVQENVARGFCNELGQMCEVSGMEFNPEPVIPIYSARPDQVEKALKHVYHTSMNKTKGKELELLLAILPDNNGSLYGDLKRICETELGLISQCCLTKHVFKISKQYLANVSLKINVKMGGRNTVLVDAISCRIPLVSDIPTIIFGADVTHPENGEESSPSIAAVVASQDWPEVTKYAGLVCAQAHRQELIQDLYKTWQDPVRGTVSGGMIRDLLISFRKATGQKPLRIIFYRDGVSEGQFYQVLLYELDAIRKACASLEPNYQPPVTFIVVQKRHHTRLFANNHRDKNSTDRSGNILPGTVVDTKICHPTEFDFYLCSHAGIQGTSRPAHYHVLWDENNFTADGIQSLTNNLCYTYARCTRSVSIVPPAYYAHLAAFRARFYLEPEIMQDNGSPGKKNTKTTTVGDVGVKPLPALKENVKRVMFYC
What is the function of this protein?
Involved in RNA-mediated post-transcriptional gene silencing (PTGS).  Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA).  RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression.  Required for reliable formation of primary and axillary shoot apical meristems.  Specifies leaf adaxial identity by repressing the miR165 and miR166 microRNAs in the embryonic shoot apex, in the shoot apical meristem (SAM) and leaf.  Represses the microRNA miR398 which targets CCS1 chaperone mRNAs for translational inhibition.  Acts as a negative regulator of AGO1 protein level.  Like AGO1, is required for stem cell function and organ polarity.  Unlike AGO1, is not subjected to small RNA-mediated repression itself.  Essential for multiple processes in development.  Coregulates, with GATA18/HAN, the shoot apical meristem (SAM) organization (PubMed:26390296).
What are the official names of this protein?
Protein argonaute 10, Protein PINHEAD, Protein ZWILLE.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSA_RHOP5
Sequence: MSEKIYDVPAEWAKRAFVDDAKYQEMYARSVNDPNGFWKDEAQRVDWIKPFSVVENTSFAPGNVSIKWFEDGVLNVAANCIDRHLKDRADQVAIIWEGDDPSESRKITYRQLHDEVCKMANVLRNRNVQKGDRVTIYLPMIPEAAFAMLACARIGAIHSVVFGGFSPDSLAQRITDCASKVVITADEGLRGGRTVPLKANVDAALRKSSAVDWVVVVKRTGADVFMDDVRDFWYHEAAEMVTTECPVEPMHAEDPLFILYTSGSTGQPKGVLHTTGGYLVFASMTHQYVFDYHDGDVYWCTADVGWVTGHSYILYGPLANGATTLMFEGVPNYPTNSRFWEVIDKHQVNIFYTAPTAIRALMQGGDEPVTKTSRKSLRLLGSVGEPINPEAWEWYHRVVGEDRCPIVDTWWQTETGGILITPLPGATKLKPGSATRPFFGVVPQIMDADANVLEGECTGNLCLAKSWPGQMRTVYGDHARFEQTYFSAYPGKYFTGDGCRRDADGYYWITGRVDDVINVSGHRMGTAEVESSLVAHPQVSEAAVVGYPHDIKGQGIYAYVTLMTGVEPTEALRKELVAWVRKDIGPIASPDLIQFAPGLPKTRSGKIMRRILRKIAEDESSTLGDTSTLADPGVVSELVEHRQNKRHV
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: CLPX_STRGG
Sequence: MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAETSEVRWEELPKPREIYEFLEGYVVGQEPAKKALSVAVYNHYKRVQAGENGGGAGREDAIELAKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFSGLEKIIESRAGAKGIGFGATIRSKLEIQASDQFQEVMPEDLVKFGMIPEFIGRLPVLTSVHNLDREALLQILIEPRNALVKQYQRLFELDGVELDFEREALEAIADQAILRQTGARGLRAIMEEVLQSVMYEVPSRKDVARVVITPDVVRNNVNPTLVPREPRTIGKNDGGRHEKSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: TX72D_SCOMU
Sequence: MLVFYALLFVTVFSNTVMGATIDKPIPKPILREAIEEIEVNKRADSHYCKEENCPPGKHCPEVPIACVYGPCCF
What is the function of this protein?
Inhibits voltage-gated potassium channels.
What are the official names of this protein?
Kappa-scoloptoxin(07)-Ssm2d, Kappa-SLPTX(07)-Ssm2d, Kappa-scoloptoxin-Ssm2d, Kappa-SLPTX-Ssm2d.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-07 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENOF1_PONAB
Sequence: MVRGRIFRLSVRDVRFPTSLGGHGSDAMHTDPDYSAAYVVIETDAEDGIKGCGITFTLGKGTEVVVCAVNALAHHVLNKDLKDIVGDFRGFYRQLTSDGQPRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPVWKLLVDMDPRTLVSCIDFRYITDVLTEEDALEILQKGQVGKKEREKQMLAQGYPAYTTSCAWLGYSDDTLKQLCAQALKDGWTRFKVKVGADLQDDVRRCQIIRDMIGLEKTLMMDANQRWDVPEAVEWMSKLAKFKPLWIEEPTSPDDILGHATISKALVPLGIGIATGEQCHNRVIFKQLLQAKALQFLQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYISVSASLENRMCEYVDHLHEHFKYPVMIQRASYMPPKDPGYSTEMKEESVKKHQYPDGEVWKKLLAAQEN
What is the function of this protein?
Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins.  Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion.  May down-regulate thymidylate synthase activity, possibly already at the RNA level, by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism.
What are the official names of this protein?
Mitochondrial enolase superfamily member 1, L-fuconate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TATB_RUEST
Sequence: MFDLGWTELLVIGVVALIVVGPKDLPKLFRNVGRFVGKARGMAREFSRAMEDAADEAGVSDIQKTFKTATNPMGSAMDSVKQATRDLTDSIDPTKFDPESETGKLAADRAENAKKIQAATARAAADRMAREAAEAAAKAEEAEAALSATPASTASSDSETKA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NFYB_HUMAN
Sequence: MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGVQQIQFS
What is the function of this protein?
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.  NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
What are the official names of this protein?
Nuclear transcription factor Y subunit beta, CAAT box DNA-binding protein subunit B, Nuclear transcription factor Y subunit B, NF-YB.
What is the protein family that this protein belongs to?
Belongs to the NFYB/HAP3 subunit family.
Protein: IF4F1_YEAST
Sequence: MTDETAHPTQSASKQESAALKQTGDDQQESQQQRGYTNYNNGSNYTQKKPYNSNRPHQQRGGKFGPNRYNNRGNYNGGGSFRGGHMGANSSNVPWTGYYNNYPVYYQPQQMAAAGSAPANPIPVEEKSPVPTKIEITTKSGEHLDLKEQHKAKLQSQERSTVSPQPESKLKETSDSTSTSTPTPTPSTNDSKASSEENISEAEKTRRNFIEQVKLRKAALEKKRKEQLEGSSGNNNIPMKTTPENVEEKGSDKPEVTEKTKPAEEKSAEPEVKQETPAEEGEQGEKGQIKEESTPKVLTFAERLKLKKQQKEREEKTEGKENKEVPVQEETKSAIESAPVPPSEQVKEETEVAETEQSNIDESATTPAIPTKSDEAEAEVEAEAGDAGTKIGLEAEIETTTDETDDGTNTVSHILNVLKDATPIEDVFSFNYPEGIEGPDIKYKKEHVKYTYGPTFLLQFKDKLNVKADAEWVQSTASKIVIPPGMGRGNRSRDSGRFGNNSSRGHDFRNTSVRNMDDRANSRTSSKRRSKRMNDDRRSNRSYTSRRDRERGSYRNEEKREDDKPKEEVAPLVPSANRWVPKFKSKKTEKKLAPDGKTELLDKDEVERKMKSLLNKLTLEMFDAISSEILAIANISVWETNGETLKAVIEQIFLKACDEPHWSSMYAQLCGKVVKELNPDITDETNEGKTGPKLVLHYLVARCHAEFDKGWTDKLPTNEDGTPLEPEMMSEEYYAAASAKRRGLGLVRFIGFLYRLNLLTGKMMFECFRRLMKDLTDSPSEETLESVVELLNTVGEQFETDSFRTGQATLEGSQLLDSLFGILDNIIQTAKISSRIKFKLIDIKELRHDKNWNSDKKDNGPKTIQQIHEEEERQRQLKNNSRSNSRRTNNSSNRHSFRRDAPPASKDSFITTRTYSQRNSQRAPPPKEEPAAPTSTATNMFSALMGESDDEE
What is the function of this protein?
Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus.  Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity.  The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability.  TIF4631 is probably essential when TIF4632 is missing.
What are the official names of this protein?
Eukaryotic initiation factor 4F subunit p150, eIF-4F p150, eIF4F p150, Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 1, eIF4G1, mRNA cap-binding protein complex subunit p150.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4G family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule.
Protein: CALGL_PSEPO
Sequence: MAATLTPEQITEYKGIFEMFDEEGNGLVKTDDLESLMSLIGINPTKRDLANMAKDVDKDKKGTFNCDGFLVLMGIYHEKSKNQDEELRAAFKVFDKEHKGYIEWDTLKYVLMNAGEPLNEHEAELMMKEADKDGDGTIDYEEFVAMMTGESFKLTQ
What is the function of this protein?
May be involved in the cellular control mechanism of the secretion of toxins from the gland into the venom.
What are the official names of this protein?
Calglandulin.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family. Calglandulin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Not found in venom.
Protein: KR102_HUMAN
Sequence: MAASTMSICSSACTNSWQVDDCPESCCELPCGTPSCCAPAPCLTLVCTPVSCVSSPCCQAACEPSACQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCGASSCCQQSSCQPACCASSSCQQSCRVPVCCKAVCCVPTCSESSSSCCQQSSCQPACCTSSPCQQSCCVSVCCKPVCCKSICCVPVCSGASSPCCQQSSCQPACCTSSCCRPSSSVSLLCRPVCSRPASCSFSSGQKSSC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 10-2, High sulfur keratin-associated protein 10.2, Keratin-associated protein 10.2, Keratin-associated protein 18-2, Keratin-associated protein 18.2.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 10 family.
Protein: CLPP2_DESHY
Sequence: MSYLVPMVIEQTNRGERSYDIYSRLLKDRIIFLGGPVTDDVANLVVAQMLFLEAEDPEKDIFLYINSPGGSISAGMAIYDTMQYIRADVHTICVGLAASMGAFLLTAGAKGKRQALPNAEILIHQPLIGGGGISGQATEIEIHAKHLLRVKERMNRILAERTGQTIERIEADTDRDRYMTAEEAKEYGLIDEVLEKPNQPKK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEMA2_LINLO
Sequence: GCIATGSVCTLSKGCCTKNCGWNFKCNPPNQ
What is the function of this protein?
Toxin with similar potency against both insect and mammalian sodium channels (Nav) (PubMed:34445875).  Delays the inactivation of most Nav channels tested (B. germanica (BgNav1); EC(50)=87. 2 nM, hNav1. 1/SCN1A; EC(50)=125. 8 nM, rNav1. 2/SCN2A; EC(50)=97. 9 nM, rNav1. 3/SCN3A; EC(50)=127. 7 nM, rNav1. 4/SCN4A; EC(50)=1150. 3 nM, hNav1. 5/SCN5A; EC(50)=149. 2 nM, mNav1. 6/SCN8A; EC(50)=1361. 8 nM, hNav1. 9/SCN9A; EC(50)=1296. 7 nM) (PubMed:34445875).  1 uM is enough to completely inhibits the inactivation, resulting in sustained non-inactivating currents (By similarity).  In addition, the toxin significantly enhances the recovery from inactivation, and the open state is not required for the toxin to interact with the channel (By similarity).  In vivo, injection into brine shrimp (Artemia salina) stops movement or causes death after 24 hours (EC(50)=2. 9 uM) (PubMed:34445875).
What are the official names of this protein?
Nemertide alpha-2.
What is the protein family that this protein belongs to?
Belongs to the nemertide family.
What are the subcellular locations of this protein?
Secreted.