PharMolix/UniProtQA huggingface dataset:
Protein: CC141_HUMAN
Sequence: MSSQGSPSVALSTTTVSSVAVQAGDSKIVIAVIKCGKWVQLQLAESQPNLLEIGSSQDETKKLLHDHELLLAKLKALEDRVWELLQEADKTAEENKDQSQVYDAMAETLGEAWAALVSMLERRTELLRLTSEFFENALEFAIKIDQAEDFLQNTHEFESAESLKSLLQLHEHHTKELLERSLALLNKSQQLTDFIEKFKCEGPNVNPELTQGAHSSCLKVDRLLELLQDRRRQLDKYLKQQWQELSQVLQICQWDQQENQVTCWFQKTIRNLQEQSLGSSLSDNEDRIHKQEELIIKAKEWNSAVEKLKSEALRILLSKDYVEKEHLQLSHQKLSQLQEEFGQLMVERNTWLKKANEFFNSANKAFDVLGRVEAYLKLLKSEGLSLAVLAVRHEELHRKIKDCTTDALQKGQTLISQVDSCSSQVSGIHEMMGCIKRRVDHLTEQCSAHKEYALKKQQLTASVEGYLRKVEMSIQKISPVLSNAMDVGSTRSESEKILNKYLELDIQAKETSHELEAAAKTMMEKNEFVSDEMVSLSSKARWLAEELNLFGQSIDYRSQVLQTYVAFLKSSEEVEMQFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDLKVSTDKEGGVQDLLLPEDMLSGEEYECVSPDDISLPPLPGSPESPLAPSDMEVEEPVSSSLSLHISSYGVQAGTSSPGDAQESVLPPPVAFADACNDKRETFSSHFERPYLQFKAEPPLTSRGFVEKSTALHRISAEHPESMMSEVHERALQQHPQAQGGLLETREKMHADNNFTKTQDRLHASSDAFSGLRFQSGTSRGYQRQMVPREEIKSTSAKSSVVSLADQAPNFSRLLSNVTVMEGSPVTLEVEVTGFPEPTLTWWVAYNDKP
What is the function of this protein?
Plays a critical role in radial migration and centrosomal function.
What are the official names of this protein?
Coiled-coil domain-containing protein 141, Coiled-coil protein associated with myosin II and DISC1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner.
Protein: TOP6B_AERPE
Sequence: MSAVAKRTRRARARAEEAARPGSTGEKYREMSVAEFFAKNKELAGFANPTRALYQTIRELVENSLDATDAKGILPWIHISIRQIEGSEGRGGRPRYTVTVEDNGIGVPVTSMAMAFGKVLFSSKYVIRQTRGMYGLGVKAAILYGQMTAGTPVEVYSATKGSQYVYMMKLVIDVQRNEPRILERGEWNKRGSWHGTRVTLSLEGDWSRAKSKILEYIKRTAVIAPYAEIILETPDGEIYYFPRSTRKLPKPPRESKPHPHGVDIEQLKSMLRSTRASTLREFLVKEFQSIGDKTAQDFLEKYGLDPDLKPRELLKKGRDKLLRRLADALMEYPFRAPKSDYLSPIGSDIIEIGLRRMFNPEWVGAVSRSPKAYRGHPFIVEVGIAYGGGIEARSEPLLLRYANKIPLLYEEREDVSYKVVSSINWRQYNVDFPAPLVVLVHIASTKVPYKGVGKESVSDVPEIEAEIRNAVQEVARRLRLYLSRKAREEEAIRRSVTLAKYIPEVAVSLAYFLRPPSKWQPPKPEEVKKIQEALIKIVARHIELPPVDGKTEDPEAIVRRIVESVELE
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit B, TopoVI-B.
What is the protein family that this protein belongs to?
Belongs to the TOP6B family.
Protein: WHIB3_MYCS2
Sequence: MPQPQQLPGPNADIWDWQMRGLCRGVDSSMFFHPDGERGRARAQREMRAKEMCRSCPVIAQCRSHALAVGEPYGIWGGLSESERELLLKRGIRRSA
What is the function of this protein?
A redox-sensitive transcriptional regulator.  Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis.  Regulates expression of the redox buffer ergothioneine (ERG).  In concert with myothiol (MSH), another redox buffer, responds to low pH leading to acid resistance.  The apo- but not holo-form probably binds DNA (By similarity).
What are the official names of this protein?
Redox-responsive transcriptional regulator WhiB3.
What is the protein family that this protein belongs to?
Belongs to the WhiB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_RICTY
Sequence: MSKISPINIKELLDAGVHFGHKTSRWNPKMASYIYGERDDVHIIDLRQSAALMSVALNAIYETVKKDGKILFVSTKIQASDIIAEYAEKCGQYYVNNRWLGGMLTNWKTIACSIEKLEKLEKTLESEETRVCYTKKEILDMSRKKDKLLLSLAGIRNLNSKPDLLVVIDTNKEHIAINEAVKLNIPIVAVVDTNSNPDNINYPIPGNDDSIRSIRLYCSLFADAALQGLEESMKVSGVDIGTMQEHTDKALTSKTISKLKQTKKFSKTQNIDEETNTEFDQALSDACENKNSDNT
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SCED_STAAM
Sequence: MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNYTFDYEGFTYHFESDGTHFAWNYHATGANGANMSAQAPATNNVEPSAVQANQVQSQEVEAPQNAQTQQPQASTSNNSQVTATPTESKASEGSSVNVNAHLKQIAQRESGGNIHAVNPTSGAAGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
What is the function of this protein?
Is able to cleave peptidoglycan and affects clumping and separation of bacterial cells.
What are the official names of this protein?
Probable transglycosylase SceD.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase family. SceD subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DI3L1_HUMAN
Sequence: MLQKREKVLLLRTFQGRTLRIVREHYLRPCVPCHSPLCPQPAACSHDGKLLSSDVTHYVIPDWKVVQDYLEILEFPELKGIIFMQTACQAVQHQRGRRQYNKLRNLLKDARHDCILFANEFQQCCYLPRERGESMEKWQTRSIYNAAVWYYHHCQDRMPIVMVTEDEEAIQQYGSETEGVFVITFKNYLDNFWPDLKAAHELCDSILQSRRERENESQESHGKEYPEHLPLEVLEAGIKSGRYIQGILNVNKHRAQIEAFVRLQGASSKDSDLVSDILIHGMKARNRSIHGDVVVVELLPKNEWKGRTVALCENDCDDKASGESPSEPMPTGRVVGILQKNWRDYVVTFPSKEEVQSQGKNAQKILVTPWDYRIPKIRISTQQAETLQDFRVVVRIDSWESTSVYPNGHFVRVLGRIGDLEGEIATILVENSISVIPFSEAQMCEMPVNTPESPWKVSPEEEQKRKDLRKSHLVFSIDPKGCEDVDDTLSVRTLNNGNLELGVHIADVTHFVAPNSYIDIEARTRATTYYLADRRYDMLPSVLSADLCSLLGGVDRYAVSIMWELDKASYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNLSVVDDIPEFKDLDEKSRQAKLEELVWAIGKLTDIARHVRAKRDGCGALELEGVEVCVQLDDKKNIHDLIPKQPLEVHETVAECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNKTLADSLDNANDPHDPIVNRLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSPIRRYSDIVVHRLLMAAISKDKKMEIKGNLFSNKDLEELCRHINNRNQAAQHSQKQSTELFQCMYFKDKDPATEERCISDGVIYSIRTNGVLLFIPRFGIKGAAYLKNKDGLVISCGPDSCSEWKPGSLQRFQNKITSTTTDGESVTFHLFDHVTVRISIQASRCHSDTIRLEIISNKPYKIPNTELIHQSSPLLKSELVKEVTKSVEEAQLAQEVKVNIIQEEYQEYRQTKGRSLYTLLEEIRDLALLDVSNNYGI
What is the function of this protein?
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  It seems to be involved in degradation of histone mRNA.
What are the official names of this protein?
DIS3-like exonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family.
Protein: CHTOP_BOVIN
Sequence: MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPMPVNIRASMQQQQQLASARNRRLAQQMENRPSVQAALKLKQSLKQRLGKSNIQARLGRPIGALARGAIGGRGLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGRGGPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALARPVLTKEQLDNQLDAYMSKTKGHLDAELDAYMAQTDPETND
What is the function of this protein?
Plays an important role in the ligand-dependent activation of estrogen receptor target genes.  May play a role in the silencing of fetal globin genes.  Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.  Required for the tumorigenicity of glioblastoma cells.  Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH.  The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (By similarity).
What are the official names of this protein?
Chromatin target of PRMT1 protein, Friend of PRMT1 protein, Small arginine- and glycine-rich protein, SRAG.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (By similarity).
Protein: FOLD_ECOLU
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQGE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CDPAS_METBU
Sequence: MLPAYLPNPFAALFGGGRPIDNGKTMSDGRRILGDGKTYRGFFVGLIFGALAGLMQMQLLEKYPVLFGVELPTFGTGGSNTTILIFALAVGSLFGDMFMSFFKRRMGLKRGAPLPVIDQLDFVLGALIFAYLASPVWFAEQFTFKVIAVILIITPLLHLATNVVGYFIGVKKEPW
What is the function of this protein?
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP.  This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
CDP-archaeol synthase, CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-archaeol synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HLDD_SALPB
Sequence: MIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQIMSGEELGDIEAIFHEGACSSTTEWDGKYMMDNNYQYSKELLHYCLEREIPFLYASSAATYGGRTSDFIESREYEKPLNVYGYSKFLFDEYVRQILPEANSQIVGFRYFNVYGPREGHKGSMASVAFHLNTQLNNGESPKLFEGSENFKRDFVYVGDVAAVNLWFLESGKSGIFNLGTGRAESFQAVADATLAYHKKGSIEYIPFPDKLKGRYQAFTQADLTNLRNAGYDKPFKTVAEGVTEYMAWLNRDA
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: FSIP1_HUMAN
Sequence: MDIIKGNLDGISKPASNSRIRPGSRSSNASLEVLSTEPGSFKVDTASNLNSGKEDHSESSNTENRRTSNDDKQESCSEKIKLAEEGSDEDLDLVQHQIISECSDEPKLKELDSQLQDAIQKMKKLDKILAKKQRREKEIKKQGLEMRIKLWEEIKSAKYSEAWQSKEEMENTKKFLSLTAVSEETVGPSHEEEDTFSSVFHTQIPPEEYEMQMQKLNKDFTCDVERNESLIKSGKKPFSNTEKIELRGKHNQDFIKRNIELAKESRNPVVMVDREKKRLVELLKDLDEKDSGLSSSEGDQSGWVVPVKGYELAVTQHQQLAEIDIKLQELSAASPTISSFSPRLENRNNQKPDRDGERNMEVTPGEKILRNTKEQRDLHNRLREIDEKLKMMKENVLESTSCLSEEQLKCLLDECILKQKSIIKLSSERKKEDIEDVTPVFPQLSRSIISKLLNESETKVQKTEVEDADMLESEECEASKGYYLTKALTGHNMSEALVTEAENMKCLQFSKDVIISDTKDYFMSKTLGIGRLKRPSFLDDPLYGISVSLSSEDQHLKLSSPENTIADEQETKDAAEECKEP
What are the official names of this protein?
Fibrous sheath-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the FSIP1 family.
Protein: Y029_MYCGE
Sequence: MKKILVIVYPEMNDVEYTNVMVVFSFIKTIQTTCYHHSLKKITASNGVVEVNNIVNTINLSEFDAVYIPGGIGATKHLDKDEKLLKTINYFKVNNLYLFAICDTPNVLFKHGIITKDEIYSSFPNPNLVMSENRSTAKVTVANKLITARSAGCALEFATVIVCTFLKDNTLNELVHKRLFGSEIKD
What are the official names of this protein?
Uncharacterized protein MG029.
Protein: SN309_ASHGO
Sequence: MADDVIDWLPYVDTLDQRYLNEVEKTVTAELAAIEQQELHPRIAELFPAVRHHWDEQYGLYKDNVVGLEGSNKRAAEDGVLSELKRRCPGIDISVYNDDSEDPVLLATIAGYRYHQDLVVTQLLPQTLENQWAINNAYLEGAEAAVRRQLQEQEQQIAQLDRHRQELQQREALRFRYLERQWRDRLHGNLERAAGNI
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor SNT309.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZIPA_ECOUT
Sequence: MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDEDVEDDEGVGEVRVHRVNHAPANAQEHEAARPSPQHQYQPPYASAQPRQPVQQPPEAQVPPQHAPRPAQPVQQPVQQPAYQPQPEQPLQQPVSPQVASAPQPVHSAPQPAQQAFQPAEPVAAPQPEPVAEPAPVMDKPKRKEAVIIMNVAAHHGSELNGELLLNSIQQAGFIFGDMNIYHRHLSPDGSGPALFSLANMVKPGTFDPEMKDFTTPGVTIFMQVPSYGDELQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDIIREVKDANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: CYB_BRANN
Sequence: MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLAACLAVQILTGLFLAMHYTSDTATAFDSVAHICRDVNYGWILRYLHANGASMFFICLYLHVGRGLYYGSYTYSETWNVGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVSALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLIMLTALSALVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIVPMLHISKQRSMMFRPLSQCLFWLLVAVLLTLTWIGGQPVEYPYVIIGQVASVLYFLIFLVFMPLVSAVENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MURI_RHILO
Sequence: MTDQPILMFDSGVGGLTVLREARVLMPDRRFVYVADDAAFPFGAWEEPALRTHILDLFVKLLDRFAPAISVIACNTASTLVIDALRERFPGHPFVGTVPAVKPAAERTRSGLVSVLATPGTVKRQYTRDLISKWAQKCHVRLVGSDRLAGLAEVYMREGFVDEEAVRAEIAPCFMEHEGLRTDIVVLACTHYPFLVNRMRKTAPWPVDWIDPAEAIARRALSLLPPVDGALPQGEPDIAVFTSGKTDFAIGRLMQGFGLSVR
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: YNID_ECOLI
Sequence: MPTKRFDKKHWKMVVVLLAICGAMLLLRWAAMIWG
What are the official names of this protein?
Uncharacterized protein YniD.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS3_THESQ
Sequence: MGQKVHPRGFRLGLSADWQAKWFNEKNYKEWLLEDEEIRKFIKNKYYHAGISEIYVERPDAERINITVKTARPGIIIGRKGAEITSLREELERKFNRRVVINIEEIKTPELDAQLVAESIASRIEKRASYKVAMKRAIMNAMRKGAQGIKVMVAGRLGGAEIARREWYLRGRLPLQKLKAIIDYGTATAWTKYGTIGIKVWIYKGDADI
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CTAA_AZOC5
Sequence: MALAGAPVAARSPRAVQVWLYAVAALIVLMVVVGGATRLTESGLSITEWKPITGALPPLSEADWQAEFDRYKTIPQYEILNKGMGLEAFKTIYWWEWGHRLLGRVIGLAFFLPFLYFALTGALRGTLLARCFGLFLLGGLQGAVGWWMVASGLTEHTSVSQYRLAVHLTLACIILTAIVAVARSLSPLAAQALPARVRLTARVLVGLVLLQIFAGGLVAGLDAGMSFNTWPLMDGHLVPAAGQLGAMQPLWRNLFENAMTVQFVHRSIAYLIFALAFLHLLDCLRLGGTAARRATLVFALVAAQAMLGILTLVHMVPLDLALAHQLGATLVLIAAMIHASDSNRRQIVA
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TXF3A_SCODE
Sequence: MEGKIIFICFLVVLLTLPELISSEVIRKEIPYKKRKFPYKSECRKACATAFTGGDESRIKDVKPGFFKCSCYYSSG
What is the function of this protein?
Acts as a voltage-gated potassium channel inhibitor.
What are the official names of this protein?
Kappa-scoloptoxin(15)-Ssd3a, Kappa-SLPTX(15)-Ssd3, Toxin SSD893.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-15 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RHOM_DROME
Sequence: MENLTQNVNETKVDLGQEKEKEASQEEEHATAAKETIIDIPAACSSSSNSSSYDTDCSTASSTCCTRQGEHIYMQREAIPATPLPESEDIGLLKYVHRQHWPWFILVISIIEIAIFAYDRYTMPAQNFGLPVPIPSDSVLVYRPDRRLQVWRFFSYMFLHANWFHLGFNIVIQLFFGIPLEVMHGTARIGVIYMAGVFAGSLGTSVVDSEVFLVGASGGVYALLAAHLANITLNYAHMKSASTQLGSVVIFVSCDLGYALYTQYFDGSAFAKGPQVSYIAHLTGALAGLTIGFLVLKNFGHREYEQLIWWLALGVYCAFTVFAIVFNLINTVTAQLMEEQGEVITQHLLHDLGVS
What is the function of this protein?
Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells.  Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor.
What are the official names of this protein?
Protein rhomboid, Protein veinlet.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: PUR1_HUMAN
Sequence: MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEAPTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKEKKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW
What is the function of this protein?
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
What are the official names of this protein?
Amidophosphoribosyltransferase, ATase, Glutamine phosphoribosylpyrophosphate amidotransferase, GPAT.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: RL2_THEP1
Sequence: MGLKRFKPVTPGRRFMVISDFSDITKTEPEKSLLAPLKKTGGRNHHGRVTVRHRGGGHKRRYRIIDFKRYDKAGIPAKVLAIEYDPNRSARIALLLYADGEKRYILAPKGVNVGDTLMSGPDAEIRPGNALPLEKIPVGTLVHNVEFTPGKGGQIARAAGTYCQIMAKEGNYALLRMPSGELRKVHIKCYATVGVVGNEDHKNEVHGKAGRVRWLGRRPHVRGVAMNPVDHPHGGGEGRGKGHHPTSPWGLPTKGYKTRRGKRPSDKFIVRRRNEA
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PAM_TAXWC
Sequence: MGFAVESRSHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKGCAPSVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKKDGIETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKKGHKTADNNDALVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFLGQPNGCANGV
What is the function of this protein?
Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine.  Catalyzes the first committed step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity.  Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate.
What are the official names of this protein?
Phenylalanine aminomutase (L-beta-phenylalanine forming), Phenylalanine ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_TRIEI
Sequence: MLSPKRTKFRKQQRGRMRGNANSGNKISFGQYALQALEPSWITSRQIEAARRAMTRYIRRGGKIWIRVFPDKPVTMRAAETRMGSGKGAPEYWVAVVKPGRIMFELGGVVEEIAREAMRLASFKLPIKTRFIVREED
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RS14_BURO0
Sequence: MAKLALIEREKKRARLVAKFAAKREALKAIVEDQSKSEEERYEARLELQQLPRNANPTRQRNRCAITGRPRGTFRKFGLARNKIREIAFRGEIPGLTKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: PSTB_MALP2
Sequence: MIKDIKNKFSKLMSSVTKTSSDLKTKRNDFKEDFDDSNIFEIRDLNFYYENGKKQALYDVNLDIKKNKVTSFIGPSGCGKSTFLRLLNRMNELLPNTTFDGDIYFEKQNIYSKKFSVLDLRIKVGMVFQKATPFPMSIYDNVAFALKNQGIKNKKILDETIEKSLRSAALWDEVKDNLNDIATDLSGGQQQRLCIARAIACKPSVLLMDEPTSALDPIATSKIEELIMELKEKYTIIIVTHSMAQAQRISDETVFFFQGKIIENGPTKNIFLKPKEKKTRDYINGRIG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PDXH_CROS8
Sequence: MSDIDHLQQIAHLRREYTKGGLRRRDLTETPLPLFERWLAQACDAKLADPTAMVVATVDEHGQPYQRIVLLKHFDERGMVFYTNLGSRKAHHLENNPRISLLFPWHMLERQVMVTGKAERLSTLEVVKYFHSRPRDSQIGAWVSKQSSRISARGVLESKFLELKQKFQQGEVPLPSFWGGFRVSLEQVEFWQGGEHRLHDRFLYQRDGDGWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.