PharMolix/UniProtQA huggingface dataset:
Protein: YCEI_SALNS
Sequence: MKKNLLGFTLASLLFTTGSAVAAEYKIDKEGQHAFVNFRIQHLSYSWLYGTFKDFDGTFTFDEKNPSADKVNVTINTNSVDTNHAERDKHLRSAEFLNVAKFPQATFTSTSVKKEGDELDITGNLTLNGVTKPVTLEAKLMGQGDDPWGGKRAGFEAEGKIKLKDFNITTDLGPASQEVELIISVEGVQQK
What are the official names of this protein?
Protein YceI.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL362_CROS8
Sequence: MQVLNSLRSAKARHPDCQIVRRKGRLYVICKTNPRFKAVQGRKKRK
What are the official names of this protein?
50S ribosomal protein L36 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: MURB_CLOB8
Sequence: MKHYGEYKNLFSKLYEESQIQLDAKMSEHIYFKVGGPVDILLTPNSIQQVKETITICKENNIPFYVIGNGSNILVKDGGIRGVVIKLCELNKIECIGNKIIAECGALLKDVSKAATEGSLAGFQFACGIPGSVGGAVFMNAGAYDGEISFVIESAEVLDDNQEIRIIPKSELNLGYRQSVVMQKGYIVLRATFNLVNGDKEKIQARVDELTKRREERQPLEYPSAGSTFKRPEGYFAGKLIEDAGLKGFAIGGACVSEKHAGFVINCKNGTAKDVLDVIYHVRDEVKKQFGVDLYPEVRIWGED
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTB_ECOUT
Sequence: MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA
What is the function of this protein?
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS18_DESOH
Sequence: MNPSPRGKKRVFHRRKYCRFCADSSLPIDYKNPKSLKSFITERGKIIPRRISGTCAKHQRAITREIKRARTIALLPYVGKPDN
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: PYRB_CORA7
Sequence: MKHLINIADHSAEEILGLMDEADRFREALEGREVKKLPTLRGRTVFTLFYENSTRTRSSFETAGKWMSADVINLSASTSSVKKGESLKDTGLTLASIGADAIIMRHPSSGAAQQLAGWVAPEGQGPSVINAGDGSHQHPTQALLDAVTMRQRLHLGADRSAAGTGFEGLKVTIVGDCLHSRVVRSNVDLLSTLGAEVTLVAPPTLLPFGVDTWPVRVSHDFDAEVPEADVVMMLRVQAERMNGGFFPSHREYASLYGLSKDRAAAMKKDAIIMHPGPMVRGMEINYAVADYDNTAVLQQVNNGVHVRMATLFTLLTNGENAGI
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: NUSB_SALHS
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLSGVATNSAYLDGLMKPYLSRLLEELGQVEKAVLRIALFELSKRSDVPYKVAINEAIELAKTFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RS8_NEIM0
Sequence: MSMHDPISDMLTRIRNAQRANKAAVAMPSSKLKCAIAKVLKEEGYIEDFAVSSDVKSILEIQLKYYAGRPVIEQIKRVSRPGLRIYKASSEIPSVMNGLGIAIVSTSKGVMTDRKARSQGVGGELLCIVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: HCC1_CRYCO
Sequence: MAPKMKAAMKAMKAPAMKGKAMTKTGLAEAWRRRPSFLRRTAGQSWRAWPRSCAAEVKKTGKLTIPGLVMVKTRKKPATKAGKREMFGKVVLVKASCQDVVKAYPVKALKTDF
What are the official names of this protein?
Major basic nuclear protein 1, Protein p14 alpha/beta chain.
What are the subcellular locations of this protein?
Nucleus.
Protein: REX_STRP8
Sequence: MVIDKSIPKATAKRLSLYYRIFKRFHADQVEKASSKQIADAMGIDSATVRRDFSYFGELGRRGFGYDVTKLMNFFADLLNDHSTTNVILVGCGNIGRALLHYRFHDRNKMQIAMGFDTDDNALVGTKTADNIPVHGISSVKERIANTDIETAILTVPSIHAQEVTDQLIEAGIKGILSFAPVHLQVPKGVIVQSVDLTSELQTLLYFMNQNHLD
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_LOBMA
Sequence: MAKFQGYLEFDGARQQSFLYPLFFREYIYVLAYDHGLNRLNRNRSIFLENSDYGKKYSSLIVKRLILRMYEQNRLIIPTKDLNQNPFLGHTNLVDYQMISILFAVIVEIPFSLRLGSSFEGKQLKKSYNLQSIHSIFPFLEDKLSHFNYVVDVLIPYPIHLEILVQTLRYRVKDPSSLHFFRFCLYEYCNWKNFDIKKKSILNPRFFLFLYNSHVCEYESIFFFLRKRSSHLRSTSYEVLFERILFYGKIQHFLKVFVNTFPAILGLLKDPFIHYVRYHGKCILATKDTPLLMNKWKYFFVNLWQCYFSVWFQSQKVNIKQLSKDNLEFLGYLSSLRLNPLVVRSQMLENAFLIDNVRIKLDSKIPISSIIGSLAKDKFCNVLGHPISKAAWTDSSDSDILNRFVRICRNISHYYSGSSKKKNLYRIKYILRLCCVKTLARKHKSTVRAFLKRLGSGLLEEFLTGEDQVLSLIFPRSYYASKRLYRVRIWYLDILYLNDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: E2FC_ARATH
Sequence: MAATSNSGEDPTLSYHHRSPFRFELLQSISSSDPRYSSLTPSSTNRPFSVSQSLPNSQLSPLISPHWDDSYSQITQKVQKSRKNHRIQLGSIANMSGGESIDIAKVIVKQESSPQNVKRVYNKSKGGTKLLKAGKRMANGEVQNGGLNGASINCRYDSSLGLLTKKFVKLIQEAEDGTLDLNYCAVVLEVQKRRIYDITNVLEGIGLIEKTTKNHIRWKGADNLGQKDLGDQISRLKSEVESMQSEESRLDDLIRERQEALRSLEEDDYCRRYMFMTEEDITSLPRFQNQTLLAIKAPTASYIEVPDPDEMSFPQQYRMVIRSRMGPIDVYLLSKYKGDSAETSDKLGNESDQKAPVGVDTPSLKIVTSDTDLKADYWFESDAEVSLTDLWSNFNS
What is the function of this protein?
Involved in transcriptional repression.  May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA.  Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development.  May play a role during the transition from skotomorphogenesis to photomorphogenesis.  Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex.
What are the official names of this protein?
Transcription factor E2FC, E2F transcription factor-2, AtE2F2.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Interaction with either DPA or DPB are unable to induce a nuclear localization.
Protein: KDSA_NEIG1
Sequence: MDIKINDITLGNNSPFVLFGGINVLEDLDSTLQTCAHYVEVTRKLGIPYIFKASFDKANRSSIHSYRGVGLEEGLKIFEKVKAEFGIPVITDVHEPHQCQPVAEVCDVIQLPAFLARQTDLVAAMAETGNVINIKKPQFLSPSQMKNIVEKFREAGNGKLILCERGSSFGYDNLVVDMLGFGVMKQTCGNLPVIFDVTHSLQTRDAGSAASGGRRAQALDLALAGMATRLAGLFLESHPDPKLAKCDGPSALPLHLLENFLIRIKALDDLIKSQPILTIE
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOTI_CANLF
Sequence: FVPIFTHSELQKIREKERNKGQ
What is the function of this protein?
Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
What are the official names of this protein?
Motilin.
What is the protein family that this protein belongs to?
Belongs to the motilin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRPF3_PONAB
Sequence: MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFRQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD
What is the function of this protein?
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
What are the official names of this protein?
U4/U6 small nuclear ribonucleoprotein Prp3, Pre-mRNA-splicing factor 3.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: WTF35_SCHPM
Sequence: MKNKDYPLRTSMDELSTKNDNEIDLEKGPLPEYNSEDGSTLPPYSDLNNPKQMGQNITKLFNWNKSTTPPDYDENRLPITDEGNNPPNTHRENHSSGTTDNSSPFLIKLLISFTSIILFNAPAVCYLKYKDAFFKNYGAAEWTLIGFWCASSLIIFTFSWYFYETWTKAVGKGIKHFLKKWRNIPMAFSEVFLFNILVGSPRVALRHISGERWGLKCSLADHIIFAILSILVFIVETVEPGSSKINIMKRLRGDNARDATQHVNEYTAVPLREMNPESEA
What is the function of this protein?
Forms toxic aggregates that disrupt spore maturation.
What are the official names of this protein?
Meiotic driver wtf35.
What is the protein family that this protein belongs to?
Belongs to the WTF family.
What are the subcellular locations of this protein?
[Isoform 1]: Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Contained within spores expressing the isoform and localizes isoform 2 to the vacuole. SUBCELLULAR LOCATION: [Isoform 2]: Ascus epiplasm. Cytoplasm. Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes in trans to all spores within an ascus. Localization to the spore vacuole is dependent on isoform 1.
Protein: NAGA_LYSSH
Sequence: MFFLSLIIRNITVVNASGRDEQMDVWMKDGKIAQIAQHIHAQGVDQLEGSGKFLLPGFIDMHIHGSAQMDTMDASDEGLHIHGPITIKEGTTSFLATTMTQSFDWFDRAQRQCGNNFSPKSDEAEVLGLHIEGPFVSKQRAGAQPLDYIVQPDMEVIKKWQALSGQKIKQITLAPEEPNGMAAVQSLSESGVIVSIGHSDATFEQMQEAVQLGASQGTHLYNQMRPFHHRDPGVVGGVLLVDAIKAELIVDFIHMHEGAVEMAYRLKGADGIILITDAMRAKGMPYGEYDLGGQLVHVTESGAHLSNGSLAGSILTMDQAVRNMRQITNCTLEELVKMSSYNAAQQLKLTNKGQLTEGYDADAVIVDEHLLLHQTIKAGRIRVQTNN
What is the function of this protein?
Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides.  Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate.
What are the official names of this protein?
N-acetylglucosamine-6-phosphate deacetylase, GlcNAc 6-P deacetylase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. NagA family.
Protein: SYH_STRS2
Sequence: MKLQKPKGTQDLLPQDSAKWQYVENFTRSIFKQYNYAEIRTPIFEHYEVISRSVGDTTDIVTKEMYDFYDKGERHITLRPEGTAPVVRSYVENKLFAPEVQKPAKFYYMGPMFRYERPQAGRLRQFHQIGVECFGSNNPATDVETIAMAYHFFEELGIKDIRLHLNSLGNPESRAAYRQALIDYLTPLKEQLSKDSQRRLEENPLRVLDSKEKEDKVAVENAPSILDYLDEESTVHFEAVRSMLDNLGITYTIDTNMVRGLDYYNHTIFEFMTEVGGNDLTICAGGRYDGLVTYFGGPETPAFGFGMGIERLILVLEKQGIELPLDTQLDVYIAVLGQEANGGALDLVQAIRKQGFRAERDYLDRKLKAQFKSADVFGAKAIITLGGSEIESGQVVVKNNQTRSQVETSLEALKTDFASILEELEKQ
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSKM_ARATH
Sequence: MVAMIMASRFNREAKLASQILSTLLGNRSCYTSMAATSSSALLLNPLTSSSSSSTLRRFRCSPEISSLSFSSASDFSLAMKRQSRSFADGSERDPSVVCEAVKRETGPDGLNIADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTGPEIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVVFPSFGERYLSTPLFQSIREEVEKMQPEV
What is the function of this protein?
Acts as a cysteine synthase.  Plays a role in the sulfide detoxification in mitochondria.
What are the official names of this protein?
Cysteine synthase, mitochondrial, Beta-substituted Ala synthase 2;2, ARAth-Bsas2;2, CSase C, AtCS-C, CS-C, O-acetylserine (thiol)-lyase, O-acetylserine sulfhydrylase, OAS-TL C.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: RL35_LEPBA
Sequence: MYKLKTNRAAAKRFKFTKSGKIKRGCAFRRHILEKKSPKMKHQSRGMHVIHETDYNRVEKLLPYGG
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ALDA_ECOLI
Sequence: MSVPVQHPMYIDGQFVTWRGDAWIDVVNPATEAVISRIPDGQAEDARKAIDAAERAQPEWEALPAIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWARRYEGEIIQSDRPGENILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYLQS
What is the function of this protein?
Catalyzes the irreversible oxidation of L-lactaldehyde to L-lactate (PubMed:6345530, PubMed:3298215, PubMed:3308886, PubMed:27671251).  Also shows high activity with glycolaldehyde and L-glyceraldehyde (PubMed:6345530, PubMed:3308886, PubMed:3275622, PubMed:16731973, PubMed:31850327).  Has weaker activity with various aldehydes such as methylglyoxal, propionaldehyde or benzaldehyde (PubMed:3308886, PubMed:16731973).  Involved in the degradation of lactaldehyde produced during metabolism of L-fucose and L-rhamnose (PubMed:3298215, PubMed:3275622).  It may be involved in several other metabolic pathways (PubMed:3308886).
What are the official names of this protein?
Lactaldehyde dehydrogenase, Aldehyde dehydrogenase A, Glycolaldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: UBP3_HUMAN
Sequence: MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQNLENSAFTADRHKKRKLLENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEGRWFHFNDSTVTLTDEETVVKAKAYILFYVEHQAKAGSDKL
What is the function of this protein?
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B.  Required for proper progression through S phase and subsequent mitotic entry.  May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites.  Associates with the chromatin.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 3, Deubiquitinating enzyme 3, Ubiquitin thioesterase 3, Ubiquitin-specific-processing protease 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP3 subfamily.
Protein: CNN1_PIG
Sequence: MSSAHFNRGPAYGLSAEVKNKLAQKYDHQQEQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHPHNYYNSA
What is the function of this protein?
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction.  It is capable of binding to actin, calmodulin and tropomyosin.  The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
What are the official names of this protein?
Calponin-1, Basic calponin, Calponin H1, smooth muscle.
What is the protein family that this protein belongs to?
Belongs to the calponin family.
Protein: PDXJ_DESOH
Sequence: MTHLAVNVDHIATLRQARGVDYPDPVAGAVLAQLAGAHGIVAHLREDRRHIQDTDVVRLRAAARRFILEMAVTPEMEKIALSVKPDLVTLVPEKRKELTTEGGLNLARHGGPVAKTIETLHRNEIPVSLFIDPDPGQVRRSHDAGAMAVEIHTGAFCEAATEKIRQKEFDRIRKAVEVARNLGLIVNAGHGLCYTTIEWMVTLKEIDEFSIGHSIVSRAALVGMDRAVRDMLALIS
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PB1F2_I77AF
Sequence: MEREQDTPWTQSTEHINIQKRENGQQIQKLEHPNLTQLMDHYLRIMNQVDMHKQIASWKQWLSLKNPTQESLKTRVLKRWRLFNKQGLTS
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: MANB_MYCGE
Sequence: MDKLRLEVERWLNHPNVNWELKQQIKELNESEIQELFSLEKPLFGTAGVRNKMAPGYHGMNVFSYAYLTQGYVKYIESINEPKRQLRFLVARDTRKNGGLFLETVCDVITSMGHLAYVFDDNQPVSTPLVSHVIFKYGFSGGINITASHNPKDDNGFKVYDHTGAQLLDTQTNQLLSDLPCVTSMLDLELQPNPKFVHTLDNEKVYKNYFRELKKVLVINNNNFKDIKVVFSGLNGTSVCLMQRFLKYLGYSNIISVEEQNWFDENFENAPNLNPEYKDTWILAQKYAKKNNAKLIIMADPDADRFAIAELNNNQWHYFSGNETGAITAYYKLNHKVFKSPYIVSTFVSTYLVNKIAKRYGAFVHRTNVGFKYIGQAINELSQTNELVVGFEEAIGLITSDKLNREKDAYQAAALLLEIARHCKEQNITLLDFYKRILSEFGEYFNLTISHPFKATATDWKEEIKALFNQLINANLTEVAGFKVVKVHLDKQTNILEFGFENGWVKFRFSGTEPKLKFYFDLTNGTREALEKQAKKIYKFFVNLLKLNKA
What are the official names of this protein?
Phosphomannomutase, PMM.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: DART_MYCBP
Sequence: MITRYKPESGFVARSGGPDRKRPHDWIVWHFTHADNLPGIITAGRLLADSAVTPTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSPMLYVVCKGHSGYSGGAGPLVHLGVALGDIIDADLTWCASDGNAAASYTKFSRQVDTLGTFVDFDLLCQRQWHNTDDDPNRQSRRAAEILVYGHVPFELVSYVCCYNTETMTRVRTLLDPVGGVRKYVIKPGMYY
What is the function of this protein?
Toxic component of a hybrid type II/IV toxin-antitoxin (TA) system.  ADP-ribosylates ssDNA, preferentially in the motif TTTW.  Its toxic effect is neutralized by cognate antitoxin DarG.
What are the official names of this protein?
DNA ADP-ribosyl transferase, DarT, Toxin DarT.
What is the protein family that this protein belongs to?
Belongs to the DarT ADP-ribosyltransferase family.
Protein: LNT1_LEPIC
Sequence: MFYNFISKDSILYRLILCFGIGIGTVFGLSPFSFFSAGVFASISCIFLFFSLNRTSIWKAFLWLLILSQILNFTAFYWIPGAISRISGANTFVSILFFFLYGLISHLKFFLFYTLFRFSKIDSASKTYILLIFPAAGTLSDMITFQIFPWYWGNLISGSIVFEQFASICGVYGLSFLLLFISSTFLILVNYYKYKNSKEFKTSIASLICIAFIYRFGLYRIGYINQSQNELKPKNLSVLMIQPDTSPGTKDLKADASYLSATMSKVFSLAIPTFENSPSLIVIPESAIPFHGTIDSEENRKEKIYSSTMEGIILYLSKHTGADVLFNELNLDENKLRNQVSLFKNLDGKTERYNKRRLLPFGEYLPMEKNFPFLRSIFQETSRYVPGEFPKLLIGNKIQNQRSFLPPEISKLNEPKTYRYEFSSIVEHTNKIRNLEYSYSILPLLCYEAMFTELVLDYFQNEQKPEVLINITNDSWFDSELEAYQHSGAVRLRAIETGLPLIRSAVSGISEVWDARGIPMIVPIGFHETGTRAFSIRLDAIESTIYTRFGNSFLWIFCILILISRLIFVSRIERKS
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase 1, ALP N-acyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LUXS_ECODH
Sequence: MPLLDSFTVDHTRMEAPAVRVAKTMNTPHGDAITVFDLRFCVPNKEVMPERGIHTLEHLFAGFMRNHLNGNGVEIIDISPMGCRTGFYMSLIGTPDEQRVADAWKAAMEDVLKVQDQNQIPELNVYQCGTYQMHSLQEAQDIARSILERDVRINSNEELALPKEKLQELHI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.