PharMolix/UniProtQA huggingface dataset:
Protein: LVX54_HUMAN
Sequence: MPWALLLLTLLTHSAVSVVQAGLTQPPSVSKGLRQTATLTCTGNSNIVGNQGAAWLQQHQGHPPKLLSYRNNNRPSGISERFSASRSGNTASLTITGLQPEDEADYYCSALDSSLSA
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
What are the official names of this protein?
Immunoglobulin lambda variable 10-54.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: DPCHE_COLHI
Sequence: MSEPHFKVIIVGGSITGLTLAHSLHKIGVDFTILEKRATVTPQEGASVGILPNGARVLDQLGLYGLVEEATAPLGATHIHFPDGFHFCSLYPKSMLDNFGYPVAFLERRRLLEVLYNALPDKSKVLVNKTVSDIEQCEDGKSAGVKVRTADGDVYEGDIVVGADGVHSRTRSELWRMSSSAGQSEDVRMEKARMSAEYSCVFGISRGPSGLKAGEQIMRMYDGRTLVVIPSKDDVVFWFLSRKLGKKYKYSEAPRFTLEDAAAECAELADAPLGNDVRFGDVWKIRQTFNMVVLEENLLRTWSFGRVLCIGDSIHKMTVNLGQGANCAIEDVAILTNLLSQCLGSKREAKPSGQELDALLRRFNDVHLSRVSHIYDTSWLIARVHARDGFVRKIIGRYVMPYFGHKFESRPFNMIANAAALEFLPLPRSSFPGWEKYKSKEDKSGSWAVVSRSVLLLVGLAILSTWWRRA
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the diterpenoid pyrones higginsianins A and B (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpchA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpchD through the action of the prenyltransferase dpchC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpchE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpchB (Probable).  The short chain dehydrogenase/reductase dpchG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpchH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Finally, the FAD-dependent oxidoreductase dpchF converts higginsianin B into higginsianin A (PubMed:32286350).
What are the official names of this protein?
FAD-dependent monooxygenase dpchE, Diterpenoid pyrone biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TYSY_BRASB
Sequence: MHQYHDLLERILSDGAEKHDRTGTGTLSVFGHQMRFNLGAGFPLVTTKRLPLKAIVHELLWFLRGDTNIKYLHDHGVTIWDEWADANGDLGPVYGYQWRSWPTPDGGHIDQIANVIDMIKRNPDSRRLIVTAWNPADVEKMALPPCHCLFQFYVVNGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGEFVHSFGDVHLYSNHVEQARLQLTRAPRSLPTMTLNPDVKDIFAFRYEDFALAGYDPHPHIKAEVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CANB_CANGA
Sequence: MGAAPSKIVETLLEDTNFDRDEIERLRKRFMKLDRDSSGSIDKNEFMSIPGVSANPLAGRIMEVFDADNSGDVDFQEFITGLSIFSGRGSKDEKLKFAFKIYDIDKDGLISNGELFIVLKIMVGSNLDDKQLQQIVDRTIMENDLDGDGQLSFEEFKSAIETTEVAKSLTLQYSV
What is the function of this protein?
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.  Confers calcium sensitivity (By similarity).
What are the official names of this protein?
Calcineurin subunit B, Calcineurin regulatory subunit, Protein phosphatase 2B regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.
Protein: TTI2_RAT
Sequence: MKLGSTEEKSGGGCSLPTEVSPPALQQAFSKILHGLSRQESSGQGNAGNAALRDLGALIEATECDKLFEGTGGGGSPREMPEILGQVAKALEKFAAPKEKADGSEEHPEVPEKATEVGLLFLKLLGKVETAKSSPVCPAWKTGLRHLSGPTYIFAITHRLKQPWTSPKSQHVAGEVLSLLFRVTECSSVAEFLCGENKDDRGRFAVVLGLLKPHLNKETWKKNPAVKHVFSWTLQQVTQPWLSQHLEKILPPSLLISDDYQTDNKVLGVQCLHHIVINVPAADLLQYNRAQVLYHALFNHLYMPEHRLIQAVLLCLLDLFPVLEKALHWQGEAARASTHCHEVLQLVLTHMESEHRLLLRRTYARNLPAFVKKLGILTARHLKRLEQVILGYLEVYDEPEDESRLKILETLKLVMQYTWPRIPCRVVVLLKALLKLICDIARDTIPTTEAAKSAVLQEATDCLILLDHCSQGQVKGLLANIALSCDDSTVVSCIRKVQGSAEAPGEDPGDD
What is the function of this protein?
Regulator of the DNA damage response (DDR).  Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.  The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC).  Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity).
What are the official names of this protein?
TELO2-interacting protein 2.
What is the protein family that this protein belongs to?
Belongs to the TTI2 family.
Protein: HSCA_HAEIN
Sequence: MALLQIAEPGQAAAPHQHRLAVGIDLGTTNSLVASVRSGQSVILNDEQERSLVPSVVHYGVEEKKVGLEAFEQASLDPKNTVISVKRLIGRSLSDVQSRYSSLPYEFVASENGLPLIITAQGAKSPIEVSSDILSRLNHIAEQRLGGELSGVVITVPAYFDDAQRQSTKDAARLAGLNVLRLLNEPTAAALAYGLDSGQEGIIAVYDLGGGTFDISILRLSKGIFEVLATGGDTALGGDDFDHLIADWVIEQTKLKPQTANQQRELITLANQAKITLTNEKSAVISWQDFSVEISREQFNELIYPLVKRSLLTCRRALKDANVESEEVQAVVMVGGSTRVPYVREQVGEFFGKTPLTSIDPDKVVALGAAIQADILVGNKTDSDMLLLDVVPLSLGIETMGGLVEKIIPRNTTIPVARAQEFTTFKDGQTAMTVHVLQGERELVDDCRSLGRFTLRGIPPMAAGAAHIRVTYQVDADGLLSVTAMEKSTKVQASIQIKPSYGLTDEEVTAMIKSSFDNAQEDLQARELAEQRVEADRVIESVIVALQADGAELLSTDEFHHIETVLKQLMDVKQGSDRDAIAQGIKALDTATQEFAARRMNASINKALTGKNLSDIENP
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity).
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ROG3_YEAST
Sequence: MGFSSGKSTKKKPLLFDIRLKNVDNDVILLKGPPNEAPSVLLSGCIVLSINEPMQIKSISLRLYGKIQIDVPLERPQDASSSSLSSSPPKIRKYNKVFYNYAWDNVNLKEYLSGLRGQSGLAGSSSSSNILGTRQRAQSTSSLKSLKGSSSPSSCTLDKGNYDFPFSAILPGSLPESVESLPNCFVTYSMESVIERSKNYSDLICRKNIRVLRTISPAAVELSETVCVDNSWPDKVDYSISVPNKAVAIGSATPINISIVPLSKGLKLGSIKVVLFENYQYCDPFPPVISENRQVTELNLEDPLNESSGEFNGNGCFVNNPFFQPDHSFQDKWEIDTILQIPNSLSNCVQDCDVRSNIKVRHKLKFFIILINPDGHKSELRASLPIQLFISPFVALSIKPLSSSNLYSLFSTTNQKDENSSQEEEEEYLFSRSASVTGLELLADMRSGGSVPTISDLMTPPNYEMHVYDRLYSGSFTRTAVETSGTCTPLGSECSTVEDQQQDLEDLRIRLTKIRNQRDNLGLPPSASSAAASRSLSPLLNVPAPEDGTERILPQSALGPNSGSVPGVHSNVSPVLLSRSPAPSVSAHEVLPVPSGLNYPETQNLNKVPSYGKAMKYDIIGEDLPPSYPCAIQNVQPRKPSRVHSRNSSTTLSSSIPTSFHSSSFMSSTASPISIINGSRSSSSGVSLNTLNELTSKTSNNPSSNSMKRSPTRRRATSLAGFMGGFLSKGNKR
What is the function of this protein?
Involved in resistance to GST substrate o-dinitrobenzene (o-DNB).
What are the official names of this protein?
Protein ROG3, Revertant of glycogen synthase kinase mutation protein 3.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
Protein: NUOK_BURCJ
Sequence: MLTLAHYLVLGAILFAIAIVGIFLNRRNVIIILMSIELMLLAVNTNFVAFSHYLGDVHGQIFVFFVLTVAAAEAAIGLAILVTLFRKLDTINVEDLDQLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: H3_PYCHE
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTELRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3, embryonic.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: QUEF_PSEPG
Sequence: MHPAAEHSPLGKSSEYIATYSPEQLFPIPRTAKWAELGVTAQTLPWQGVDYWNCFELSWLLPSGKPVVAIGEFAIPADSPNIIESKSFKLYLNSLNQTVFASLGELQACLEKDLSAAAGKPVGVKVRTLAEVEAQGVVALPGQCIDGLDVAISNYEQPQPELLRCNTAQVVEETLHSHLLKSNCPVTGQPDWGSVVVEYKGRALDHASLLTYLVSFRQHADFHEQCVERIYLDLKNLLQPEHLTVYARYVRRGGLDINPYRSTGVIKPDNKRLVRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAL1_VIBPA
Sequence: MSELIQNVKASFEQVLGYAPSHIIQAPGRVNLIGEHTDYNDGFVLPCAINYQTVVAAAKREDNIVRVVSVDYGNAVDEFDITQAITFQQDKMWANYIRGVVKCLLARGYQFTGADISVSGNVPQGAGLSSSAALEVVIGQTFKVLFNLEISQAEIALNGQQAENEFVGCNCGIMDQMISAEGRENHAMLLDCRSLETEAVSMPEDMAVVIINSNKKRGLVDSEYNTRRQQCEEAARIFGVKALRDVTIEQFNEKVAELDEMVAKRARHVITENDRTVEAAQALRAHDMKRMGELMAESHASMRDDFEITVKEIDTLVEIVKEVIGDQGGVRMTGGGFGGCIVALVPPALVDDVKAEVEAKYQAATGLKESIYVCQAQNGAGLVEVL
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIC5_HUMAN
Sequence: MFLKAGRGNKVPPVRVYGPDCVVLMEPPLSKRNPPALRLADLATAQVQPLQNMTGFPALAGPPAHSQLRAAVAHLRLRDLGADPGVATTPLGPEHMAQASTLGLSPPSQAFPAHPEAPAAAARAAALVAHPGAGSYPCGGGSSGAQPSAPPPPAPPLPPTPSPPPPPPPPPPPALSGYTTTNSGGGGSSGKGHSRDFVLRRDLSATAPAAAMHGAPLGGEQRSGTGSPQHPAPPPHSAGMFISASGTYAGPDGSGGPALFPALHDTPGAPGGHPHPLNGQMRLGLAAAAAAAAAELYGRAEPPFAPRSGDAHYGAVAAAAAAALHGYGAVNLNLNLAAAAAAAAAGPGPHLQHHAPPPAPPPPPAPAQHPHQHHPHLPGAAGAFLRYMRQPIKQELICKWIDPDELAGLPPPPPPPPPPPPPPPAGGAKPCSKTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKIRGCDKSYTHPSSLRKHMKIHCKSPPPSPGPLGYSSVGTPVGAPLSPVLDPARSHSSTLSPQVTNLNEWYVCQASGAPSHLHTPSSNGTTSETEDEEIYGNPEVVRTIH
What is the function of this protein?
Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate.  Binds to DNA (By similarity).
What are the official names of this protein?
Zinc finger protein ZIC 5, Zinc finger protein of the cerebellum 5.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PA2HB_BOTAL
Sequence: SLFELGKMILQETGKNPAKSYGAYYCYCGWGGQGQPKDATDRCCYVHKCCYKKLTGCNPKKDRYSYSWKDKTIVCGENNSCLKELCECDKAVAICLRENLNTYNKKYRYYLKPLCKKADAC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks enzymatic activity (PubMed:17270350).  Is myotoxic and displays edema-inducing activities (PubMed:17270350, PubMed:17915277).  In vitro, produced time-dependent, irreversible neuromuscular blockade in isolated mouse phrenic nerve-diaphragm and chick biventer cervicis preparations (PubMed:17270350, PubMed:19463969).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog BaTX, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SELA_SALPC
Sequence: MTSETRTLYSQLPAIDRLLHDSAFLSLRDRYGHTQVVDLLRRMLDDARDVIRNTQTLPDWYADWAQEAKLRLENAAQSALRPVINLTGTVLHTNLGRALQAQEAIEAVTQAMRAPVTLEYDLDGAGRGHRDRALATLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHAKDYRQAVNENTGLLMKVHTSNYSIEGFTKTVEEAELAEIGRELDIPVVADLGSGSLVDLSQYGLPKEPMPQQLIAAGVSLVSFSGDKLLGGPQAGIIVGKKAMIAQLQSHPLKRALRADKMTLAALEATLRLYLHPEALAEKLPTLRLLTRSEASIREQAQRLQARLAARYGDEFALEVKPCLSQIGSGSLPVDRLPSAAMTFTPHDGRGSRLEALAARWRTLPVPVIGRIYDGRLWLDMRCLEDESRFMEMMLK
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_BACP2
Sequence: MSQFVNVIGAGLAGSEAAWQIAKRGIKVNLYEMRPVKHTPAHHTDKFAELVCSNSLRANALTNAVGVLKEEMRHLDSAIIAAADESSVPAGGALAVDRHEFAANVTDRVKNHPNVTVFQEEVQSIPEGPTIIATGPLTSEALSKELKSLTGEEYLYFYDAAAPILEKDSIDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALISAETVPLKEFEKEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGDQKEVFRLIPGLEEAEIVRYGVMHRNTFINSPSLLKPTYQFKNREDLFFAGQMTGVEGYVESAASGLVAGINAARFVKGEELVTLPEETAIGSMAYYITSTNKKSFQPMNANFGLLKDLGVRIKNKQERYAEYAKRAIETIQTISKSL
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A1AT_CYPCA
Sequence: MPATCLLHTMLTLPSPSTRNLRSIQMPRARTFSSPSRYRNGFEHAGCRCQGSTLSQIYSSLGYSGLQASQVNEGYEHLIHMLGHSREAMQLEAGAGVAIREGFKVVDQFLKDVQHYYNSEAFSVDFSKPEIAAEEINQFIAKKTNDKITNMVKDLDSDTVMMLINYMYFRGKWDKPFDAQLTHKADFKVDEDTTVQVDMMKRTGRYDIYQDPVNQTTVMMVPYKGNTSMMIIFPDDGKMKELEESISRHHLKNWHDKLFRSSVDLFMPKFSITATSKLKGILEDMGVTDAFGDTADLSGLTEEVKVKVSQVVHKAVLSVDEKGTEAAAATTIEIMPMSLPDTVILNRPFLVLIVEDTTKSILFMGKITNPTE
What are the official names of this protein?
Alpha-1-antitrypsin homolog.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PURL_PROMA
Sequence: MIKSKDYLVDYNVELALKKEGLTKADYIEICNRLKRSPNRTELGMFGVMWSEHCCYRNSRSLLSNFPTTGKNILVGPGENAGVVDLGEGQRLAFKIESHNHPSAIEPFQGAATGVGGILRDIFTMGARPIALLNSLRFGPLDTPINVGLLEGVVSGIAHYGNCVGVPTVGGEVAFDKSYSGNPLVNAMALGIMETKEIVCSGAKGIDFPVIYVGSTTGRDGMGGASFASSELTQASIDDRPAVQVGDPFLEKGLIEGCLEAFKTGYVVAAQDMGAAGLTCSCSEMAAKGGVGIELDLDLVPAREKNMTAYEFLLSESQERMLFVVEPGKEELIMNKFRKWGLQAKVVGKVLEENIVRVIHEKQIVVNLPADSLAEDTPVNKHELLEEPPGFIKDHWKWDETSLPKVSIKGVHFKENNTILDWNQIILRLLDDPTIASKRWIYNQYDYQVQNNTIIAPGIGDAALIRLREIENQNQNSNRGIAAVVDCPNRWVALDPERGAIAAVAEASRNISCVGAKPLAVTDNLNFSSPEDPIGYWQLAKACKGLSKACVVLETPVTGGNVSLYNETALPNGLKQPIQPTPVVGMIGLIQDINSATRQGWKDQGDQIYLLGTSIDPSILNNQNISLAATSYLENIYGLKTGRPPLIDLEFEKLVQLFLRESIANNLIKSAHDISDGGLVIGLAESCISSGLGIECNLPEIDNRLDKLLFAEGGSRVLVSVSPNNIHNIKNSLNNFNIANSEQISFNYLGTVTDNKYFQININQTKIIDLSVNEITNKFERSIPRRINSTIVS
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFA_SHEB8
Sequence: MTEYLLLLISTVLVNNFVLVKFLGLCPFMGVSSKLESAIGMSMATTFVLTLASILSYLVNQYLLLPFDLSYLRTMSFILVIAVVVQFTEMVVQKTSAALHRALGIYLPLITTNCAVLGVALLNVNEKHDFIQSAIYGFGAALGFSLVLILFSAMRERLAAADVPLPFKGGAIAMITAGLMSLAFMGFTGLVK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MRR1_MONRU
Sequence: MKEEIDAPVSTDASGTDLENARDQPSGEKPTAVDIYLVEWDGPNDPELPMNFPLWKKSLITCIFSTLTIWVTFSSSVFSAAAGITSKEFHVSVEVMTLGTSLTVLGFTVGPLVWGPMSELYGRLKPLYIGYAIFIIFQVPVAVAQNLETLMLARFFLGFFGTSALAIIPGALADFWGPVERAIAISLFSAATFVGPIFGPIIGGFIVDSSLGWRWTAWITMIPASFFGIIAFLTLPETYHPVLLQRRASRLRKETRIWAYHSRLDENTPTFGEILTKYLFRPIQMLFLEPILVCMTIYISLIYGILYLFFVAYPIAFREVRNWKSLGIAALPFLGILVGVLMGCLLVTIATRLWYAPKLQNGSVVPEDRLPPMIVAAILLPIGLFWFGWTSSPSISWAPQAIAGAPIGMGILMIWMQGLNYLIDVYLVVANSAMSANTLIRSAVGAAFPLFATAMYHKLGVDWATSLLGFLSIAMIPIPVIFYFYGAKIRALSRFSPKW
What is the function of this protein?
MFS transporter; part of the gene cluster that mediates the biosynthesis the mycotoxin citrinin, a hepato-nephrotoxic compound to humans due to inhibition of respiration complex III (Ref. 1).
What are the official names of this protein?
Citrinin biosynthesis cluster MFS transporter mrr1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. CAR1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KV5AB_MOUSE
Sequence: DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNSLPRTFGGGTKLEIKR
What are the official names of this protein?
Ig kappa chain V-V region HP R16.7.
Protein: ALG10_EMENI
Sequence: MNAQPRSALALAARYAVPFGLLLIPIWMTQVNSVVPEPYLDEAFHIPQAQAYWSHQWTQWDPKITTPPGLYLFSYAVCALILLLRGSPEHLDPPALRATNAAAAAVLLPLRLQTALDTVRKQRNTRPSGAWLSHTVLNICLFPPLFFFSGLYYTDVLALLVVIEAYNWDLSRGRPNAVKLETAVFLVLGVLALLFRQTNIFWVSVFFGGLQVVRRLRRVTKNCESTNVADILAAGSRNELYDPLVLDASLVDYVKTAASLCSVALNNLGSVITSLVPYLIILATFGGFVLWNGSVVMGHKEFHTASLHIAQMLYIWPYFVFFSWPLLLVPMANIVLPKFMLPKFLNQGFPASRRRLPSLLTVLIILPIMLAVVHFNTIVHPFTLADNRHYVFYVFRILLNSHPYTRYVATLVYFLGAWMIISAMGYSPVTAAPGLASVVRTQAPPASATSAEERTEKTQKLERKQKGFKKSAQVASSAPAPIDPKVLADLQEHIRRRQRLEHETSRVSFVLVWLAATALSLISAPLVEPRYLIIPWVMWRLHLPPSPTPVIYRRASDEKDLEARIAVNFPLFLETVWFLLVNVITGTLFLRGGFEWPQEPGKVQRFLW
What is the function of this protein?
Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
What are the official names of this protein?
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Alpha-1,2-glucosyltransferase alg10, Alpha-2-glucosyltransferase alg10, Asparagine-linked glycosylation protein 10, Dolichyl-phosphoglucose-dependent glucosyltransferase alg10.
What is the protein family that this protein belongs to?
Belongs to the ALG10 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GSTX1_SOLTU
Sequence: MAEVKLLGLRYSPFSHRVEWALKIKGVKYEFIEEDLQNKSPLLLQSNPIHKKIPVLIHNGKCICESMVILEYIDEAFEGPSILPKDPYDRALARFWAKYVEDKGAAVWKSFFSKGEEQEKAKEEAYEMLKILDNEFKDKKCFVGDKFGFADIVANGAALYLGILEEVSGIVLATSEKFPNFCAWRDEYCTQNEEYFPSRDELLIRYRAYIQPVDASK
What are the official names of this protein?
Probable glutathione S-transferase, Pathogenesis-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. HSP26 family.
Protein: HPTR_STAAR
Sequence: MFKVVICDDERIIREGLKQIIPWGDYHFNTIYTAKDGVEALSLIQQHQPELVITDIRMPRKNGVDLLNDIAHLDCNVIILSSYDDFEYMKAGIQHHVLDYLLKPVDHAQLEVILGRLVRTLLEQQSQNGRSLAPCHDAFQPLLKVEYDDYYVNQIVDQIKQSYQTKVTVSDLIQHIDVSESYAMRTFKDHVGITIVDYLNRYRILQSLQLLDRHYKHYEIADKVGFSEYKMFSYHFKKYLQMSPSDYCKQAK
What is the function of this protein?
Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources.  Activates uhpT expression to facilitate glucose-6-phosphate/G6P utilization by directly binding to its promoter.  Antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility.
What are the official names of this protein?
Transcriptional regulatory protein HptR.
What are the subcellular locations of this protein?
Cytoplasm.