PharMolix/UniProtQA huggingface dataset:
Protein: RLMF_YERPP
Sequence: MLSYAPENAYQRASTMENKKVFPKEKSGLHPRNRHRSRYDFDALSVSCPELIPFLAPTAYGDISVDFADPLAVKMLNKALLKHFYGIEYWDIPADSLCPPIPGRADYVHHLADLLASCNGEVIPKGKNIALLDIGVGANCIYPIIGQREYGWRFTGTDIDSHALSAAKMVVSMNPTLKNTLRLKQQKDPHAIFEGVWAVNERYDATLCNPPFHGSAEEAAATTRRKLHKLGKNEVAAKPVQNFGGKNSELWCEGGEEGFVSRMVAESVAKAQNCFWFTSLISKKTTLPAIYHALRYVKAVEVRTIEMAQGQKVSRFVAWTFLTLEQQAAWVAERWA
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPA3_ORYSJ
Sequence: MTPQLQPKQMHWARADSSDFGGQIPAPRSGHTAVSIGKSKVVVFGGFADKRFLSDIAVYDVENRIWYTPECNGSGSDGQAGPSPRAFHVAIVIDCNMFIFGGRSGGKRLGDFWMLDTDIWQWSELTGFGDLPSPREFAAASAIGNRKIVMYGGWDGKKWLSDVYIMDTMSLEWTELSVTGSVPPPRCGHSATMIEKRLLVFGGRGGAGPIMGDLWALKGVTEEDNETPGWTQLKLPGQSPSPRCGHSVTSGGPYLLLFGGHGTGGWLSRYDVYYNECIILDRVSVQWKLLATSNEPPPPRAYHSMTCIGSRFLLFGGFDGKNTFGDLWWLVPEGDPIAKRDLVPNVDSDSKPSNVTGGAQHSASQESQAGESPMIDLAKRLGISLSLEASASFVDEINDKELIELSSMLFGESPPTGDQHACIQALRDHWTSIPANSIQLQELGPLLRDYQRLILRRYLENSFTSFYEKEVHRFFHLKNASELRMDDIPILLMEYGKLLST
What is the function of this protein?
Acts synergistically with RAB5A and VPS9A to regulate dense vesicle-mediated post-Golgi trafficking of major storage proteins in the seed endosperm during grain filling and maturation.
What are the official names of this protein?
Protein GLUTELIN PRECURSOR ACCUMULATION 3.
What are the subcellular locations of this protein?
Prevacuolar compartment. Golgi apparatus, trans-Golgi network. Protein storage vacuole.
Protein: CSTF3_HUMAN
Sequence: MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASELKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVEGNGPVESNAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKRIR
What is the function of this protein?
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
What are the official names of this protein?
Cleavage stimulation factor subunit 3, CF-1 77 kDa subunit, Cleavage stimulation factor 77 kDa subunit, CSTF 77 kDa subunit, CstF-77.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNM3A_HUMAN
Sequence: MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
What is the function of this protein?
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443).  DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443).  It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443).  May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity).  Plays a role in paternal and maternal imprinting (By similarity).  Required for methylation of most imprinted loci in germ cells (By similarity).  Acts as a transcriptional corepressor for ZBTB18 (By similarity).  Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity).  Can actively repress transcription through the recruitment of HDAC activity (By similarity).  Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity).
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, Cysteine methyltransferase DNMT3A, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.
Protein: CAST2_XENLA
Sequence: MELHILEHRLKVASIAKENIQLFTYGLIKLAFLSSKTRCKFFSLTETPEDYTIIVDEEGFLELPSSEHLSVADATWLALNVVSGGGSSSSSQPIGVTKIAKSVIAPLADQNISVFMLSTYQTDFILVRERDLPFVMHTLAAEFTILQVVNGETVAADNLGVTNGFVKPKLVQRPVIHPLSSPSNMFCVTSLDPYTLPTVTTLLMDVMFYSNGVKDSVVGSEEPDHIRFFSFSLIEGYISLVMDVQTQQRFPSNLLFTSASGELWKMVRIGGQPLGFDECGIVAQISEPLAAADIPAYYISTFKFDHALVPEENINGVINALQVSQAEKH
What is the function of this protein?
Functions as a negative regulator of the TORC1 signaling pathway.
What are the official names of this protein?
Cytosolic arginine sensor for mTORC1 subunit 2, GATS-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the GATS family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: GATC_RHILW
Sequence: MSVDLATVKRVAHLARIAVSEDEANRMVGELNGILGFVEQLSEVNVDGVEAMTSVTPMAMKKRTDEVTDGSKAADIVANAPVTDHNFFLVPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: MTE5_ECOLX
Sequence: MKDKVFVPPIKSQGIKTKLVPCIKRIVPKNFNGVWVEPFMGTGVVAFNVAPKDALLCDTNPHLISFYNALKNKDITGDLVKDFLYREGEKLLLSNGEYYYEVRERFNNYKEPLDFLFLNRSCFNGMIRFNSKGGFNVPFCKKPNRFAQAYITKISNQVDRISEIISKGNYTFLCQSFEKTIGMVNRDDVVYCDPPYIGRHVDYFNSWGERDERLLFETLSSLNATFITSTWHHNDYRENKYVRDLWSSFRILTKEHFYHVGASEKNRSPMVEALITNIAKDIIDHIEKSSGDILVIEE
What is the function of this protein?
An alpha subtype methylase that recognizes the double-stranded sequence 5'-GATATC-3', methylates A-2 on both strands, and protects the DNA from cleavage by the EcoRV endonuclease.
What are the official names of this protein?
Type II methyltransferase M.EcoRV, M.EcoRV, Adenine-specific methyltransferase EcoRV, Modification methylase EcoRV.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: NTPPA_NITOC
Sequence: MRGLFPPIALASTSPRRQALLAQIGVEFKRLDIKVDESPQPAERPTSYVYRLALAKARAGWGQQPPRGRLPVLGADTAVVVENEILGKPADRAQAGVMLTRLSGRSHQVLTAVALTNGDEAQYRLSVSTVTFKRLTKDECEAYLASGEGLDKAGAYAIQGWAALFISRLEGSYSGVMGLPLYETGELLGNLQERKK
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBAA_VIBCH
Sequence: MKLNHRILLLIAPVILLSAAASSYIIYTSQKNALLKRTDSYLQLNIEKLASHYRQAQSLVSSYAFTLAKSDIIRHYFSLEKNPYRELELVDNLRETLQILQPNEKQLVSLSILNGHEELLYYAENSSDPFAELDPKVMAYIKQRFASTQKNSDISYTVNSAGEDILVRYDMLDTQTLSTPLSYNRQDVFFVVVYVVLEQFSQLRKKIEFDNQSPIFFTHSPPSYRTGLLQSVELQPGFYAILDPAPKLINAQLHSIQRELLLSFGVSALVTVLMLLLLLYRHVINPILHLDKQLEEVENNQRKNIEKLNTDDEIGRLSSRFYAMYSELHSTYQRTKALAENDHLTKLANRYQFQVQADLLLSRCYDTQHIWVMYIDLDNFKYVNDKYGHQIGDSLLVSFATHVRQLCKNFEASHNTYSIAARLSGDEFAILLVSPKRFNDCAKIFAQRLLAPIQNKDNSPLSHFPITASIGIATFPKDGEHIEKLLLNADTAMYQAKNAGKNQVAYYSQALDQIVQRRNNIERALRLGLFDQEFNLAYQPYFTCSGKRLVGFEVLLRWQSELLGEVSPEEFIPIAEQTGLFGTIDRWVISKAFQEISTLQAIVKEPIQVSINLSSAELNSLKLAQFIHRQAEQFGVSPAWIDFEITETFAADSQSFPLLHELSRLGYGLTIDDFGSGYTSITQLVQYPVQKIKFDRHFLDTLIATNKQNVIRPLIDLCHSQSMKVTAEGIESETMHQWLADYECDYMQGFYFGYPMSLSEISPWLHASNHKKKSYAQDHYCFTEPSQSECR
What is the function of this protein?
Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development.  Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage of development, results in the overproduction of an extracellular polymeric substance that accumulates in the matrix of biofilms.  This yields biofilms lacking the typical structure consisting of pillars of cells separated by fluid filled channels.
What are the official names of this protein?
Biofilm architecture maintenance protein MbaA.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein.
Protein: FLOWR_DROVI
Sequence: MSFAEKLTGLMARPNQQDPAGGPEQPWYLKYGSRVLGIVAAFFAILFGLWNVLSIIGLSVSCLVAGIIQMLAGFVVMALEAPCCFICIEKVGSVADMMDTKPLYFRAGLYCAMAVPPIFMCFGLASLFGSGLIFATGAVYGMMALGKKASAAEMRAAAQQASYGGNAAPTTNDRAGIVNNAQPFSFTGAVGTDSNV
What is the function of this protein?
A calcium channel that regulates synaptic endocytosis and hence couples exo- with endocytosis.  Required in the nervous system and necessary in photoreceptor cells (By similarity).
What are the official names of this protein?
Calcium channel flower.
What is the protein family that this protein belongs to?
Belongs to the calcium channel flower family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Upon fusion of the synaptic vesicle with the presynaptic membrane, protein is present in the periactive zones, where endocytosis is known to occur.
Protein: GUN2_BACSU
Sequence: MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSIKGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGYIDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTPNVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQLKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSREWLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKDSTKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTARYWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTGNIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN
What are the official names of this protein?
Endoglucanase, Carboxymethyl-cellulase, CMCase, Cellulase, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
Protein: RL16_BORRA
Sequence: MLSPRKVKYRKKQRGRLSGEAQKGNKISFGEYGLVSLEADFITARQIEAARVAMTRRVKRGGKVWIRIFPDIPYTKKPAETRMGKGKGGVDHWNAPVKLGTVMFEISGVPRELAESAMMLASSKLPVKTTFVVRRDLR
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: NUSB_BDEBA
Sequence: MKLTARRQARELALQVLFQTEFAPQISYQTFLEVFEQSLDPEVITYADLIVTGVKSNKEAIDSKIQASSAHWKVERMATIDRNILRIAVYEMRFAADPIKENIAINEAVEIAKKYGTSDSGSFVNGLLDQVGKAH
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RL13_PSEAE
Sequence: MKTYTAKPETVQRDWFVVDAAGQTLGRLATEIARRLRGKHKPEYTPHVDTGDYIVVINAEQVRVTGAKTTDKMYYHHSGFPGGIKSINFEKLIAKAPERVIETAVKGMLPKNPLGRDMYRKLKVYKGASHPHTAQQPQELKI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: MURA_WIGBR
Sequence: MNQFVIKGSNKLTGDVFISGSKNASLPILFATILSEEEIEIQNVPKIKDTDFAIKLLRYLGATVEENKSIYINAKNISIYHAPCNLVKTMRASIWALGPLLARFGEGSISLPGGCEIGNRPVDLHLYGLKKLGAKIYLKDGYVKANVKGRLHSARIVMNKISVGATLTIMSAATLAIGITIIENAAREPEIIDTANFLISLGAKINGVGTNTIFIKGVKKLKGGVYKILPDRIETGTFLVAAAISRGKITCYDTNPNTLNIVLKKLHESGARIEIGKDWIKLDMIDKRPKAVKIETSPYPGFPTDMQAQFTVLNLISYGSSIITENIFENRFMHISELIKMGGRAIIKNNNIFCYGVNQLFGAQVIAKDLRTAASLIIAGCIADGITTVDCLYHIDRGYCQIENKLKNIGANIKRLKK
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJGA_SALPB
Sequence: MTKQPEDWLDDVPGDDIEDEDDEIIWVSKSEIKRDAEELKRLGAELVDLGKNALDKIPLDADLRDAIELAQRIKMEGRRRQLQLIGKMLRQRDVEPIRQALDKLKNRHNQQVVLFHKLEHLRDRLIVEGDDAVAEVLTLWPHADRQQLRSLIRNAKKEKEGNKPPKSARQIFQYLRELAENEG
What are the official names of this protein?
UPF0307 protein YjgA.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: EIF3L_ASPOR
Sequence: MSYEERANAHPNLGDESDVEEEALVNDYREQVNFDDSMSELDRTTSLGAGSQTQDLQAQLAAAATPLEYQATLETKFASYDNYCSLFHYILNSDGPVELEVPSYYWAWDVIDEFIYQFESFCRYRNRVARSGSNEEEAQLLRENPNTWGCYSVLNVLYSLIQRSQINEQLAAIKRGEDPMAFAGEYGSRPLYKMLGYFSIIGLLRVHCLLGDFSLALKTLDDIEMNKKAMFARVMAAHFTTYYYVGFSYMMMRRYGDAIRMFSHILVYVSRTKNFQKGGNSYDAIAKKNDQMYALIAICVALHPTRLDDTIHSALREKYGEQLHRLQHGGPEALPLFEELFRSACPKFISPTPPDFDNPSVNVDPVDHHTAIFMDEVKNTLYNPTIRSYLKLYTTMDLQKLAGFLEVEPEKLRSWLLVNKQRSRQVRWVEGGLLEGEPVAANDLDYALENDLIHVSETKAGRRLVDWYLRNLARVY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YSCH_YERPE
Sequence: MTVTLNRGSITSLMSSSQAVSTLQPVASELKTQLENKLKSESAEKTREVLWQQYYASNPPDHAVLEVLATPVREALLARFGQHQGSVVPAIDLPELRSVLQQFDSFGKRWEAILLQVLEGIKPNESQVGLPYLSELINKELMILLPSNSIVDSLLHNSHQIDMDT
What is the function of this protein?
Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.
What are the official names of this protein?
Yop proteins translocation protein H, Low calcium response locus protein P.
Protein: IF4E2_WHEAT
Sequence: MAEVEAALPVAATETPEVAAEGDAGAAEAKGPHKLQRQWTFWYDIQTKPKPGAAWGTSLKKGYTFDTVEEFWCLYDQIFRPSKLVGSADFHLFKAGVEPKWEDPECANGGKWTVISSRKTNLDTMWLETCMALIGEQFDESQEICGVVASVRQRQDKLSLWTKTASNEAVQVDIGKKWKEVIDYNDKMVYSFHDDSRSQKPSRGGRYTV
What is the function of this protein?
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity).  Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor isoform 4E-2, eIF(iso)-4E-2, eIF(iso)4E-2, eIF-(iso)4F 25 kDa subunit, eIF-(iso)4F p28 subunit, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PAIP1_XENLA
Sequence: MSDGFERAPGVGRGRGRGRGIETAEGGKTPGFSGASGAGDEPGRAKAAGSQQQEPLRPPRTGPPGGGGDAGAAQTSHKRTSPAAQLPAHTYTMAVSKAQPADRGRLLSNLSANAAEFYPSGYSVEANNCVEENGCYPVLPEGTLTEYVQDFLNHLTEQPGSFEAEVFPFSDVLNNCVTTDESLQELVELIYQQAISVPNFSYTGARLCNYLSNNLHINPQNQNFRQLLLKRCQTEFEKRDQAAKGDGAARKQFHAFVLFLGELYLNLEIKGAKGQVTRAEILQSGLQELLNSLFSNPVDDNLMCAVKLLKLTGSVLEDAWKEKALSCMEEVMLRMKNVVLDANCSRDVKQMLLKLVELRSSNWGRVHAASTFKEATPENDPNYFMNEPTFYTSEGVPFTAADPDYQEKYQELLDREDFFRDYDENGTDGGDSYFEDDDDNEMDPEMEEAYEKFCLESEHKKKQ
What is the function of this protein?
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs.
What are the official names of this protein?
Polyadenylate-binding protein-interacting protein 1, PABP-interacting protein 1, PAIP-1, Paip1 protein, Poly(A)-binding protein-interacting protein 1, XlPaip1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_CALS4
Sequence: MIGIIDYGMGNLRSVEKALKYVGYDAKITSDAKEIKNFEALILPGVGAFPDAIRVLIKTGMAEEIKIHIEKGKPFLGICLGMQLLFEKSFEGGKTEGLKIFKGNVVGLPKGNKIPHVGWNSLTIKKDTPFLKGIKNGDYVYFVHSYYVNGNEKDFEYAVTEYGIEIPAVIIKDNVFSCQFHPEKSGETGLKILKNFGEMIKCL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMHA_HELHP
Sequence: MQTLIESEFNAHLQSAQKIFTLTPAIQKAADILIQSLKNGGKILICGNGGSAADAQHFAAELTGRYKRERKGLAGIALSVDTSALTAIGNDYGFEYVFSRQVESLAQKGDVFFGISTSGNSHNVLKAAQIARDMDCFVIGLSGRDGGKLSALCDINLIMPDNDTPRIQELHILIIHILCDIIESECGENGNTNVIS
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_CUPMC
Sequence: MTKTFRNPQLTKNGELKHLLSIEGLSRDMITHILDTASQFVSLSDSDREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAAKRLSADVLNLNINASSTSKGESLLDTINNLSAMSADMFVVRHASSGAPYLIAEHVAPHVHVINAGDGRHAHPTQGLLDMYTIRHFKKDFTNLTVAIVGDILHSRVARSDIHALTTLGVPEVRAIGPRTLLPSGLEQMGVRVFHNMEEGLKGVDVVIMLRLQNERMTGALLPSAQEYFKAYGLTPERLALAKPDAIVMHPGPMNRGVEIDSAVADGPQSVILNQVTFGIAVRMAVMGIVAGNND
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RECR_SHESM
Sequence: MKFSPLLDELIQSLRCLPGVGPKSAQRMAFQLLERDRKAGLKLASALSSAMSDIGHCQSCRTYTEESLCPICASHKRGSSSTICVVETPADVLAIEAGGHFSGRYFVLLGHLSPLDGVGPEELGLALLERHLASGDVAELILATNPTVEGEATAHFIADMARRHKVVISRIAHGVPVGGELEYVDSTTLALSFNGRIPL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: SNX11_HUMAN
Sequence: MGFWCRMSENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGTSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEIEACVQGRSTMTVSDAILRYAMSNCGWAQEERQSSSHLAKGDQPKSCCFLPRSGRRSSPSPPPSEEKDHLEVWAPVVDSEVPSLESPTLPPLSSPLCCDFGRPKEGTSTLQSVRRAVGGDHAVPLDPGQLETVLEK
What is the function of this protein?
Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.
What are the official names of this protein?
Sorting nexin-11.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein; Cytoplasmic side. Endosome.
Protein: YEM4_YEAST
Sequence: MDAFSLKKDNRKKFQDKQKLKRKHATPSDRKYRLLNRQKEEKATTEEKDQDQEQPALKSNEDRYYEDPVLEDPHSAVANAELNKVLKDVLKNRLQQNDDATAVNNVANKDTLKIKDLKQMNTDELNRWLGRQNTTSAITAAEPESLVVPIHVQGDHDRAGKKISAPSTDLPEELETDQDFLDGLL
What are the official names of this protein?
Uncharacterized protein YER034W.
Protein: DNAA_ECOBW
Sequence: MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADAPQLRFEVGTKPVTQTPQAAVTSNVAAPAQVAQTQPQRAAPSTRSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOB3C_BOVIN
Sequence: MALCLKQVFSKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRSVVRLPPGENIDDWIAVHVVDFFNRINLIYGTMAERCSETSCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMALLMDWIESLINDEDVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIREFSLVDQRELEPLREMTERICH
What is the function of this protein?
May regulate the activity of kinases.
What are the official names of this protein?
MOB kinase activator 3C, Mob1 homolog 2C, Mps one binder kinase activator-like 2C.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.