Protein: NBEA_CAEBR
Sequence: MDISETEYNDSDPPVQENGNGKAVVEDEVNDEESNMETVDLGLDDKTSDASSQNVFKNIDNEPSDDQQNVEESENITLEKPEEISAPPTVVSTSQDVSPPPAIESLPPLLEGKELELEDDVTSSLPRLLSKTTLIHSNEEGADETIQRLISSLHSNSPNMDRTQIVDHLFNLLVGGHFDQESKFVIEHVANVDHMLTLLSHCDCDLQNEIWSLFLAVMKKSNRNLEACTRVGLISKNFFLNLVLDLLPEAPPLLADLLVQIIAALVAYSINVKQTKHLLRALRSTKDQWPPNSLKLLHVLKEMPQHDSADVFFSFPGKDQSGIILPPIKTMPYQQGWTFATWLRMEPLNSVTFEKEQPVLYSFRTSKGIGYSCHIFGNCLVVNVEKAKGKEQSRCVKAELGARKWHHIAIAHCYSRWGRSDIKCFIDGQLAETIELSWVVTSTTSWDRCSIGVSADGAVNTAFCGQMGAMYLFAESLSLQQANSLFCLGPAYQSTFKHDSETSLPEGYKKHLFDGHLHSSLVFAYCPKNCHGQLCLFTPPKTAANTYFVQIPHAVMKEGVEVITTHSIHKSLQSVGGIQILLPLFAQIDLPSSHDNTIDGDVCQTLLSLISLLLSSSQSSQQQLFHSKGFLIISSCLQEASPSHLSMKVLEQIIHIAKFLLRCPAGGPLLKHLFDYILFNPKLWIRARPEVQVHLYQYLATDFLANNNFSQMLRRVPTVIEMCHTLKHFYWLALPQTVSDYTVEERPENFATAEIVSIRSAILTFINRIIISSNSPDEEEKARDQEIHTLLNLLATVREDDNLYDVLALVTRLLAEHPAIMIPAIDKNKALGIIFNLLAAPNELIRIPALKILGFFLSRSTLKRKTESMGSQNLFSLIGERLLSHKRTISLPTYNVLLEVLVEQMTPTFTYAAHQPAQPDWKFENPHLLKVIAHVISQCEETESLVQIKKCFLIDIINLCRESKENRRTILQMSVWQDWLIGLAYVFHTSESQNEVSELVWEAFSILLHHALRHEYGGWRVWVDTLAIAHSKVSYEKFKRRLAEAKAKAEKAETGEEAKMEPTPVYRAPEFAWSEVHIRLLADLLSGIERTVEEWKTQEGGISDQCNASENQVFVGNVVHVISQLADSLIMACGGLLPLLASATAPNNDMEIVDPCQQQLPISVAASFLMRFAKLVDTFVLASGVSFSELEQEKNMPAGGVLRQSLRISATVTVRHILASRIQQPDTPRYETNSAKKNQCIMDFVKEALENFSPEGLENVERLVQDSDITRIKGVVYRDMVEENRQAQFLALSVIYLVSVLMVSRYRDILEPPSSPSPFFDSTTTKQENAERGEKLFEFSHNPLFLELPESSSEAVANGKVANDGDHASIKNGSDHSENGADEETEEKGEQGQGDNGGTIAAIKVANSDMKNDGNEYNEEELKKMHQSNGRRPSTLMPPQQTAERRAYLTTKLQTALETCAPLLREMMSDFRGYLQKTLVGTHGQEIMNDTKVLETLRNRNASVIELVMLLCSQEWQTSLQKHAGLAFIELVNEGRLMAHATRDHVLRVANEADFILNRLRAEDVSKHAQFEAESREQLNARYEEYSRCDLLIVSGRLRDSLNATRLLDKMSAILTDGDDSKSGSQFWKLDVWEDDSRRRKRFVPNPYGSRHEEANLPEGEKNEEPEISEQERIRKILKGLFSQRHATTTSTGGQELVDESDIDKWAQEVDPTPSSQSACFSTAAKLIVPGVVVPGTLSVTASDLFFDANESDPNYKKQCAQVLRYCEALHARWNLQEIRAIFLRRYLLQNTALEMFLASRTAIMFAFDSEDTVRKVVYQLPRVGVGVKYGLPQSRKTSLMTPRQLFKHSDMCAKWQKREISNFDYLMFLNTVAGRTFNDLSQYPVFPWILTNYTSDTLDLSVASNFRDLSKPIGALNEARRKFFTDRYASWDDDLVPAFHYGTHYSTPAFTLNWLLRLEPFASMFINLHDGKFDHPDRITHSIKDSWDRCQRDSHDVKELIPELFYLPEMFRNSSKFNLGRRADGTLVDDVVLPPWAESPEHFVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAVRATNVFYHLTYEGTVTQKMAETPGQVSAIEQQILSFGQTPSQLLAEAHPPRHSIMTMAPTMFRRHDDDLCMMMKYISNSPVVYLAANTFHQLPHPTVVGVAQNLVFSLNKWDNSYSYGSTQRSALSMDPSNVEGQVALPLTADPQLATAASTTPIARRHLGDAFDQRLQVQCSNFVTTTDSKYIFACGYPDYSFRIVDTDSGRVRQAVYGHGDVVTCIARSETSLFSDCYVVTGSMDCTVVLWHWNGTTGFIAGEYNQPGEVPSPRSILTGHEASISALCVSAEHGLVVSGCEDGVILIHTTASDLLRRIRGHGTVTQLSMSRECILLVLFDSKRMTTYSSTARKLNEVLSEEKIECVTVTRDGEFAVTGAVNGRITIWRMFPLNKLYTYQPLNSAVRSVAVVASHRFILGGLDSGAIVVFNADFNRWHYEYKHRYIQNSSATKPAQASPQK
What is the function of this protein?
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane.  May anchor the kinase to cytoskeletal and/or organelle-associated proteins.  Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells.  Thought to act as a negative regulator of lin-12 activity in vulval precursor cells.  May have a role in the internalization process from basolateral surface of polarized epithelial cells (By similarity).
What are the official names of this protein?
Putative neurobeachin homolog, Suppressor enhancer of lin-12.
What is the protein family that this protein belongs to?
Belongs to the WD repeat neurobeachin family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus.