PharMolix/UniProtQA huggingface dataset:
Protein: GREA_CLOB1
Sequence: MSEAKKYVMTYEGVKKLEEELEFLKTVKRKEITEKIKVALSFGDLSENSEYDEAKNEQAFVEGRIIQLENMLKNASIVDENEVPKDVVSVGSIVKVKDYEFDEEVEYIIVGSAEADPMNNKISNESPVGHGLIGKKAGDIIEVAVPDGVSKYEILEVNRA
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: NUSB_GEOKA
Sequence: MKRHEAREKALQALFQIDVGRIPPDEALHNVTGGGDIDPFLRQLVFGVVEHQEEIDELLRANLEKWTLERVANVDRAILRMATYEMKYADDVPVSVSLDEAVELAKKFGDWKSGSFVNGVLSKVKAALQK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PG001_VACCC
Sequence: MHVPASLQQSSSSSSSCTEEENKHHMGIDVIIKVTKQDQTPTNDKICQSVTEITESESDPDPEVESEDDSTSVEDVDPPTTYYSIIGGGLRMNFGFTKCPQIKSISESADGNTVNARLSSVSPGQGKDSPAITREEALAMIKDCEVSIDIRCSEEEKDSDIKTHPVLGSNISHKKVSYEDIIGSTIVDTKCVKNLEFSVRIGDMCKESSELEVKDGFKYVDGSASEGATDDTSLIDSTKLKACV
What is the function of this protein?
The protein is truncated in this vaccinal strain and presumably inactive, because the lack of signal peptide prevents the protein of being secreted.  In the other strains inhibits host immune defense by binding to host chemokines.  Binds host CC chemokines (beta chemokines) such as RANTES with high affinity, but not CXC or C chemokines (alpha and gamma chemokines) (By similarity).
What are the official names of this protein?
Inactive chemokine-binding protein, vCKBP.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG001 family.
Protein: METK_METMP
Sequence: MANIVVKRLERTPIDEIPVEIVERKGIGHPDSICDGIAESVSVALCKMYKEKMGVVLHHNTDQVELVGGYAYPELGGGCMVSPIYILLSGRATMEVLDKETGKIIKLPVNTTAVNAARDYLKKALRNMDLEKDVVVDCRIGQGSVDLVEVFDRKRTEIPHANDTSFGVGHAPLSTTEKIVLETEKLLNSDALKAEIPAVGEDIKVMGLREGKKITLTIAMAAVDKYVNSCADYVKVKELAKAKVEENAKKYLDGHELEVCINTADDDEDCIFLTVTGTSAEMGDDGSVGRGNRANGLITPFRPMSMEATSGKNPINHIGKIYNILSNIIAEDVAKIEGVRECQIRILSQIGKPVTEPKILDIEMIPENGFELEELSPKAKEVAQKWLDNISEVTERIVSGNVTTF
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase 2 family.
Protein: SYM_SODGM
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADIWVRYQRMRGHQIYFICADDAHGTPIMLKAQQLGIAPEEMINEMNLEHQTDFAGFGISYDNYHSTHSEENQQLSTLIYQRLKENGFIKSRTISQLFDPEKVMFLPDRFVKGSCPKCHSPDQYGDNCEVCGATYNPTDLINPKSAVSGTTPVMRESEHFFFDLPAFSEMMRAWTRSGALQEQVANKMQEWFESGLQEWDISRDAPYFGFEVPDAPGKYFYVWLDAPIGYMSAFQNLCQKRSDLRFDEFWDVDSKADLYHFIGKDIVYFHSLFWPAMLEGSHFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTYLAHLDAECLRYYYAAKLSSRIDDIDLNLEDFIQRVNADIVNKVVNLASRNAGFINKRFDGQLAATVADPALYATFVNAATSIGDAFSSRETSRAIREIMALADLANRYVDEQAPWVVAKQEGREADLQAICSMGIQLFRVLMTYLKPVLPSLAERAKAFLATPLDWDDLSAPLLSHRIRPFKALFSRIEAAQVDAVIEVSRLEAAAAGEPAAAPAGALAEAPIAPTINFDDFAKVDMRVALIKRAESVKGSDKLLKLTLDLGGTSRQVFSGIRAAYPDPQVLEGRLTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGALPGMPVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_EHRRW
Sequence: MPTINQLVRSPRKSRALLNKAPALQHNPQKRAVCVKVYTTTPRKPNSALRKVARVKIAGYGSEVIAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGALDSRGVQNRKKARSKYGVKKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: HEM3_RHIME
Sequence: MQTKPFRIGTRGSPLAMAQTHETRDRLAAAHGLPPEMFEIVILSTKGDRITDRSLAEIGGKGLFTEELEQQLLSGDLDFAVHSSKDMPTKLPEGLFLSAFLPREDIRDAFVGRSAKRLVDLPQGATVGSSSLRRQALIRRLRPDIDVITYRGQVETRLRKLAEGQVDGTLLAYAGLRRLGMEHVPTELLDPEEFPPAPAQGAICVEARIGDDRINTLLAAIDDPRTHEAVSCERGFLATLDGSCRTPIAGYAQSDGTHIRFAGMILTPDGTTSHQIEIDGRAADAERLGQEAGERIRAKAGPGFFSSWS
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: MOX12_DROME
Sequence: MAHPRKAVATPATLQLGPPAQTAQSPAATLRHSRTASSSRRLSLIRCFISCHTFNLFLLLLLLASGVRAASKLATRSNKTSGSSTASGVGAGTAATSAAAAAASGTPIWDHAIDLNDDFRILWQIINQDITFEIQARTLGYVGFGFSPDGNLAGADMAIGWVDKGQTYFQDRHVTRNGDPEPVVDPSQDYMLMLGYENATHTVLRFRRKLDTCDPSHDIAITNDTMRLLYMYHAQDPPHGSVRPGTLPDPARAFRPYRPMVLMQRAQLPMPSPTHDERVRVLELRNEDVELPAGDLPLFWCKMFKLEDINRKHHLIRYEPIYDSSSSVHYLQHITLHECQGAHAELEEMAREQGRPCLGARSIPLACNAIVASWSRGSEGFTYPHEAGYPIESRQAKYYLMETHYNNLKPDFAQLHARQMADNSGLKIYFTHVLRPNDAGTLSIGMDPNWRHIIPPGQKRVVSEGQCIEDCTGYAFPQQGINIFAVMMRTHQIGKEVKLRQIRQTEELPPIAHDSNIDVAYQDFRRLPQSVHSMPGDRLIAECIYDSSSRKAITLGGLTMKEESCTVLTLYYPRQKKLTTCHSLPSLPTVLHSLGIEQLATDSNPVLISSPPELAGMTLEARLISYDWENQFGEFQEATRKGSFKPICWGAKNHVVPGSEFLEGYSINVTKTYKKHRRCKPKRPLAPPTERTAPPPASDLSELPVLHELDNNNIIEGAARSSRSSATDVHSLSRGSGRHFISCLLWLGASSWWLLLMLRT
What are the official names of this protein?
MOXD1 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the copper type II ascorbate-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CYOE_BUCAI
Sequence: MFKNYIEITKPGIIIGNSTLITGGFLFASRHAAFNYVLFIYTILGASLVIASACVFNNLIDIDIDKKMKRTSNRVLSKKLLPVFSVFNFAIFLGVLGLSILGCLVNFISMSLAVFGFFIYVVLYTMFYKRRSFYSTFIGSFSGSTPSVIGYTAVSNTIDICSILLFVIVIFWQMSHFYSISIMRIKDYREAKIPVFSVVKGVAITKKHIFFYVLNFSFFSSLFTFLGYLSYNFLLLSSIVNFYWSFLSYSNIKKNNDKKNARKLFYFSIIVIVFFNFLISIDVFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: U85A1_ARATH
Sequence: MGSQIIHNSQKPHVVCVPYPAQGHINPMMRVAKLLHARGFYVTFVNTVYNHNRFLRSRGSNALDGLPSFRFESIADGLPETDMDATQDITALCESTMKNCLAPFRELLQRINAGDNVPPVSCIVSDGCMSFTLDVAEELGVPEVLFWTTSGCAFLAYLHFYLFIEKGLCPLKDESYLTKEYLEDTVIDFIPTMKNVKLKDIPSFIRTTNPDDVMISFALRETERAKRASAIILNTFDDLEHDVVHAMQSILPPVYSVGPLHLLANREIEEGSEIGMMSSNLWKEEMECLDWLDTKTQNSVIYINFGSITVLSVKQLVEFAWGLAGSGKEFLWVIRPDLVAGEEAMVPPDFLMETKDRSMLASWCPQEKVLSHPAIGGFLTHCGWNSILESLSCGVPMVCWPFFADQQMNCKFCCDEWDVGIEIGGDVKREEVEAVVRELMDGEKGKKMREKAVEWQRLAEKATEHKLGSSVMNFETVVSKFLLGQKSQD
What is the function of this protein?
Involved in the O-glucosylation of trans-zeatin and dihydrozeatin.  Also active in vitro on cis-zeatin.  Not active on N-glucosylated substrates.
What are the official names of this protein?
UDP-glycosyltransferase 85A1, Cytokinin-O-glucosyltransferase 2, Zeatin O-glucosyltransferase 2, AtZOG2.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: MIAA1_MYCMM
Sequence: MRPLTIIGPTGTGKSDLAIEIADRLSGKIAVEIVNADAYQLYRGMDIGTGKVPLAQRRGIPHHQLDVLDVTETATVAGYQRSAAADIEAIASRGALPLLVGGSMLYVQSLLDDWAFPAKDPAIRARWERRLAQVGPARLHAELVRRDPAAAAVIPLNDARRTVRALEVVEITGRPYAASAPRIGSPRWDSAIIGLDCETKVLDERLAARTKAMFDRGLIEEVISLLPCGLARGVTASRALGYAQVMEALKAGADTQALDSARQQTCLATRRYVRRQRSWFRRDRRVRWLDATVSTAAHRTAIIEAVLGAWRRAS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase 1, Dimethylallyl diphosphate:tRNA dimethylallyltransferase 1, DMAPP:tRNA dimethylallyltransferase 1, DMATase 1, Isopentenyl-diphosphate:tRNA isopentenyltransferase 1, IPP transferase 1, IPPT 1, IPTase 1.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: FRDA_HELPJ
Sequence: MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKKSEGDNEDLHFLDTVKGSDWGCDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVNGEHVIITERDDRHGYILSRDFGGTKKWRTCFTADATGHTMLYAVANEALHHKVDIQDRKDMLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASALETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELASRDVVSRRILEHIQKGYGAKSPYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADSEEQTKDNMQGAPTNEPEYGQAMAKQKGWIPIKPMQHYSMGGVRTNPKGETHLKGLFCAGEAACWDLHGFNRLGGNSVSEPVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHFLLHNEGKEDVYEIRERMKEVMDEKVGVFREGKKLEEALKELQELYARSKNICVKNKVLHNNPELEDAYRTKKMLKLALCITQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQDMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERDAEILKTILELEKLGKDRIEVQHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHDLLDQHNANLKGEHHE
What is the function of this protein?
The fumarate reductase enzyme complex is required for fumarate respiration.
What are the official names of this protein?
Fumarate reductase flavoprotein subunit, Quinol-fumarate reductase flavoprotein subunit, QFR flavoprotein subunit.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HFLC_SHIFL
Sequence: MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIETVKMLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVTTPAADNAIAEAAERVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRSQGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSLRAYENSFSGNQDVMVMSPDSDFFRYMKTPTSATR
What is the function of this protein?
HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda.  HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins (By similarity).
What are the official names of this protein?
Modulator of FtsH protease HflC.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family. HflC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: PSBN_YUCGL
Sequence: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y623_CHLPN
Sequence: MYFTRDPVIETVITSREGYKLSVRNTKHFSQDPFMVEAIEVISLGNICFFRNCDHSKPFLVPAGDYEVMEVRDTKINLKAVGLDRGVKIAGGREALIKLTKSTPLPVIDEKPLADSPEEGTEPTSPSKKEKKEARKDSFKGEKWKEKKKLSRRRNHKEIAEVTGASQEILDTVKEELWEESQENEIVEQKKFSLLPPPAKLISEVISQTVVDPVVTSADLNESLQALVRESSDLINALLSADDAIHFPETEEEPTSASFEESSAMFFPETSSATEEE
What are the official names of this protein?
Uncharacterized protein CPn_0623/CP_0124/CPj0623/CpB0649.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0623/CT_504/TC_0791 family.
Protein: SYFB_AQUAE
Sequence: MKVPYSWLSEFVELSDVSPEEIAEKLSLRSVEATVETFGIDLDGVVFGKVVEVKEHPTKKKLAVVKVQVQEHIFIDVVTVDKSVREGDGVIVALPNAKVGNMCVTEREFDGVVSKGLLLSAQELGLEEKSEGVLKIHEDFKPGTDANEILGFGEKIIEIDITPNRGDMLSVRGVARDLSAIFRLPKKKPEEPTYEETGEFFIEIEDEDCKRYRGVVIEGVEIKESPLYIKKRLWQCGIKSINNVVDITNYVMLRDGQPLHAFDLSKVEGGIIVRSAKKGEKIITLDGEERELDEDILVIADREKPLAVAGVIGGLESGIKENTKDILLESAYFNPFRVRKASKKLGIQTESSYRFERNVDIERVDRAQDYAVYLILKHAGGKVKVVKDVYREKYKPKKVFLPQGKYIRYAGESYKNEEVKEILDALEIPNEIMRCGVEVLVPSHRSFDIQRDVDLIEEIMRVKGYEHYTSETLKLPSIANLWKDNLLEVKKYLRDKGLTEVINFSFEDSKLYELLNLPLPELEVINPLNPTQRYMRNTLITSLLRTAVYNDRNYNYDQAVFELGKVFFKEGEENRLGILLKGNKPRTLKEEKWEPYDLTEIIAGIFALFGLEPEFRNAKRNFLHPYVQGEVYLEGEFVGFFGKLHPKIAKELELKGEPFVAEIEIERVLSKKRLPHYREVAKFPPVVRDIALVMDKELDVNKLLIDTKSQIGELLEEVRVFDVYTGEKVGEGKKSVAVRLVLRSKTGSLKDEEANELVNKLVNYLKEKYGVELRT
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AL1A1_BOVIN
Sequence: MSSSAMPDVPAPLTNLQFKYTKIFINNEWHSSVSGKKFPVFNPATEEKLCEVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDHLLLATMEAMNGGKLFSNAYLMDLGGCIKTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLMFLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEKILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTIKISQKNS
What is the function of this protein?
Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:7786847).  Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (PubMed:7786847).  This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable).  Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic.  By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification.  Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity).  Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
What are the official names of this protein?
Aldehyde dehydrogenase 1A1, 3-deoxyglucosone dehydrogenase, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic, Retinal dehydrogenase 1, RALDH 1, RalDH1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell projection, axon.
Protein: LFTR_AROAE
Sequence: MIPWLAGRPDFPPVEQALEDPDGLLAAGGELSPAWLLAAYRRGIFPWYTEDQPILWWSPDPRLVLIPAHLRISRSLRRTLRQQRFEVRFDTAFADVIAACAEPREPGGGTWISPEIRQAYLRLHELGYAHSVESWVDGTLVGGLYGIALGRAFFGESMFSRRSDASKVALVHLAAHLQRLGFAAIDCQMTTAHLLSLGAEEMPRARFCAGLANWTNEGPGPGRWSCEKAAEISRNFS
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPD_PSEAE
Sequence: MSQAHTPSAPLAEVYDVAVVGGGINGVGIAADAAGRGLSVFLCEQHDLAQHTSSASSKLIHGGLRYLEHYEFRLVREALAEREVLLAKAPHIVKPLRFVLPHRPHLRPAWMIRAGLFLYDHLGKREKLPASRGLRFTGSSPLKAEIRRGFEYSDCAVDDARLVVLNAISAREHGAHVHTRTRCVSARRSKGLWHLHLERSDGSLYSIRARALVNAAGPWVARFIQDDLKQKSPYGIRLIQGSHIIVPKLYEGEHAYILQNEDRRIVFAIPYLDRFTMIGTTDREYQGDPAKVAISEEETAYLLQVVNAHFKQQLAAADILHSFAGVRPLCDDESDEPSAITRDYTLSLSAGNGEPPLLSVFGGKLTTYRKLAESALTQLQPFFANLGPAWTAKAPLPGGEQMQSVEALTEQLANRYAWLDRELALRWARTYGTRVWRLLDGVNGEADLGEHLGGGLYAREVDYLCKHEWAQDAEDILWRRSKLGLFLSPSQQVRLGQYLQSEHPHRPRVHAA
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOTL_LEGPH
Sequence: MMRGIDSRHELDPTLLLRDTRTFTQRLADFFADPTNISIVLISLAAVSYYFSEAATFLLIMGGIFFLYSYTRKQKLPFRLPQISRAKDYNDLKPGINKPNIARGITFFGNDRKTGEELWFANDDMRTHALIFGSTGSGKTETLVSLSYNALVQGSGFIYVDGKGDNSLYAKVFSMVRSMGREDDLLLINFMTGARDIVGPQEKRLSNTLNPFCQGSSSMLTQLVVSLMGSSGQSSDGDMWKGRAIAFVEALMRLLVYMRDEGAILLDANTIRNYFDLQRLESIVIDKVFPRDDQESVNIETIPKLVTDPLRNYLNTLPGYNKEKKGKQVSQVLEQHGFITMQLVRSFSSLADTYGHIIRTNLAEVDFKDVVLNRRILVVLLPALEKSPDELSNLGKIIVSSLKAMMAAGLGEEVEGDYRDVILRKPTNAPTPYMCILDEYGYYAVQGFAVVPAQARSLGFSAIFAGQDLPAFQKASKEEAASIGANTNIKICMKLEDPTETWDFFTKTAGEAYVTKVDSFQTKETSIANSYMDTKSSSFEKRARVDLLDLKEQTEGEAHIFFKSKIVRARMFYANPKPVKQLKINQFLKVEPPPDDYLMKLQKQLASFQSILESGDLSINKAVENEEITLISKALKESTIVEPIERGVAALIAFHGQNEPEPVEDIVEEEVEGALTIFSKLRIDPNAPPILVADKEVFSEPLLPINETRNQMITIERLAGAKDKYAGTVANELIKDFQIATSYPPEERDVIDVQELTGIIRDLSAKISAEREKANKKAAEELT
What is the function of this protein?
Component of the Dot/Icm type IVB secretion system (T4BSS), which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:17040490, PubMed:22694730, PubMed:32513920).  Part of a subcomplex which recruits effector proteins and delivers them to the core transmembrane subcomplex (PubMed:23028312, PubMed:32513920).  Plays a central role in the assembly of the subcomplex (PubMed:32513920).  Required for the recruitment of IcmS and IcmW to the inner membrane and for the translocation of adapter-dependent substrates (PubMed:23028312).  May have ATPase activity (Probable).
What are the official names of this protein?
Type 4 coupling protein DotL, T4CP.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Note=Localizes to the poles of the cell.
Protein: KTDAP_MOUSE
Sequence: MKIPILPVVALLSLLALHAVQGAALGHPTIYPEDSSYNNYPTATEGLNNEFLNFKRLQSAFQSENFLNWHVITDMFKNAFPFINWDFFPKVKGLRSAAPDSQ
What is the function of this protein?
May act as a soluble regulator of keratinocyte differentiation.  May play an important role in embryonic skin morphogenesis (By similarity).
What are the official names of this protein?
Keratinocyte differentiation-associated protein.
What are the subcellular locations of this protein?
Secreted.
Protein: NDK_FRATH
Sequence: MTKQRTLSIIKPDAVEKNVIGEIYSRFEKAGLRIIAAKMKHLSKAEAEGFYAVHKDRPFFSALVEFMISGPVMIQVLEGENAIAKNRELMGATNPKEAKAGTIRADFADSIDANAVHGSDAEDTAAQEIRYFFSDTEIFG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCM7_HUMAN
Sequence: MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:25661590, PubMed:9305914).  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425).  Required for S-phase checkpoint activation upon UV-induced damage.
What are the official names of this protein?
DNA replication licensing factor MCM7, CDC47 homolog, P1.1-MCM3.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: EX7L_HAEIN
Sequence: MSDNIYSVSQLNSAARQMLEGNFCQIWLTGEISNFTQPVSGHWYLTLKDENAQVRCAMFRMKNLRVAFRPQNGMQVLVRANVSLYEPRGDYQLIIDSMHPAGEGLLQQQFEALKMKLAAEGLFAQNLKKTLPHFSKAVGIITSSTGAALQDILHILARRDPSLKVVIYPTAVQGKEATAEIVQMIELANARQEVDVLIVGRGGGSLEDLWCFNEEEVARAIFRSTLPIISAVGHETDVTIADFVADLRAPTPSAAAELVSRNQDELLQQLRHQQQRLDMAFDRLFTRKSQRLKQLALRLQNQHPQNQLRAQQAKNEQLTHRLQLAILRQFENTQQKFTALSVRLKQNPLPYRIQRYQQGLEQLKVRLNFCVNRQVTERQNKLATLCGKLDGLSPLKVLARGYSIAENPQGKAIVSVKDVNQGDFITTQVADGKIVSKVL
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.