PharMolix/UniProtQA huggingface dataset:
Protein: NART_STACT
Sequence: MNKSKGGLQLTVQTLSLVAGFMVWSIIAPLMPMISQDIKITSSQISIVLAIPVILGSVLRIPFGYLTNIIGAKWVFFSSFIILLFPIFLLSQAQSVNMLMLAGFFLGVGGAVFSVGVTSIPKYFPKDKVGLANGIYGMGNLGTAVSSFLAPPIAGAIGWQSTVRLYLIVMAVFAIVMFFLGDAKEPKVKIPLVAQTKDLLKDLRTYYLSFWYFITFGSFVAFGIFLPKYLVDHYELTTVDAGIRAGIFIAIATFLRPLGGIIGDKIDAVKALKVDFLFMIIGAIILGIANDMILFTVGCLTVSVCAGIGNGLVFKLVPQYFQKEAGVANGIVSMMGGLGGFFPPLVITYVTSITGTSHLAFIFLALFGVLALVTMWHLSKKNRSLAYK
What is the function of this protein?
Probably required for nitrate uptake under anoxic conditions.  Also possibly involved in excretion of nitrite produced by the dissimilatory reduction of nitrate.
What are the official names of this protein?
Probable nitrate transporter NarT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLS1_MOUSE
Sequence: MENHSKQTEAPHPGTYMPAGYPPPYPPAAFQGPSDHAAYPIPQAGYQGPPGPYPGPQPGYPVPPGGYAGGGPSGFPVQNQPAYNHPGGPGGTPWMPAPPPPLNCPPGLEYLAQIDQLLVHQQIELLEVLTGFETNNKYEIKNSLGQRVYFAVEDTDCCTRNCCGASRPFTLRILDNLGREVMTLERPLRCSSCCFPCCLQEIEIQAPPGVPVGYVTQTWHPCLPKFTLQNEKKQDVLKVVGPCVVCSCCSDIDFELKSLDEESVVGKISKQWSGFVREAFTDADNFGIQFPLDLDVKMKAVMLGACFLIDFMFFERTGNEEQRSGAWQ
What is the function of this protein?
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:32110987).  Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (PubMed:32110987).  Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity).  Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724).  May contribute to cytokine-regulated cell proliferation and differentiation (PubMed:12010804).
What are the official names of this protein?
Phospholipid scramblase 1, PL scramblase 1, Ca(2+)-dependent phospholipid scramblase 1, Mg(2+)-dependent nuclease, Transplantability-associated protein 1, NOR1, TRA1.
What is the protein family that this protein belongs to?
Belongs to the phospholipid scramblase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the perinuclear region in the presence of RELT. Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.
Protein: DNAJ1_MYCTO
Sequence: MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEAAKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGTVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ 1.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_ERWT9
Sequence: MNIQALLSEKVSHAMIAVGAPADCEPQVRQSAKAQFGDYQANGMMAVAKKMGMPPRQLAEKVLEQLDLSGIAAKVEIAGPGFINIFLAQEWLSAQIDGVLTAPKLGVAPVAPKTVVIDYSAPNVAKEMHVGHVRSTIIGDAAARTLEFLGHKVIRANHVGDWGTQFGMLIAFLEKQQSEHHEAIALADLEAFYREAKRTYDEDPAFAERARGYVVKLQGGDEYCRKMWKQLVDVTMTQNQLIYDRMNVTLTRDDVMGESLYNDMLPGIVADLKAKGLAVESEGATVVFLDEYKNKEGEPMGVIIRKKDGGYLYTTTDIACAKYRYETLKADRVLYYIDSRQHQHLMQAWTIVRKAGYVPDSIPLEHHMFGMMLGKDGKPFKTRAGGTIKLSDLLDEAVDRATKLVAEKNPDMPADELNALANIVGIGAVKYADLSKSRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKAGIDAEAVSGVTRIVDDREAALAVRLLQFEETITQVARDGMPHVMCAYLYDLAGLFSGFYEHCPILNAEDEATKQSRLRLALLTAKTLKQGLDTLGIETVERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPT_ALCBS
Sequence: MTDLSTLRFFRTPAHGCSYLEDRQASTLFVDPQAALSPELYSELSLLGFRRSGDYLYRPHCDSCNACIPARVRVDDFLPRRRHRRILKHNADLTVHREPARFSRELYTLYAAYINDRHGDGDMYPPSEEQFTNFLTCEWADTHFYGFREKGKLLAVAVTDQLNDGLSAVYTFFDPTLPERSLGVMALLWQIEQCQRLRLPYLYLGYWIRQCQKMSYKNQYQPLEILASGSWKEQSEPNDSGD
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_AERHH
Sequence: MTTKTGILLVNLGTPAAPTTAAVKAFLSQFLHDQRVVDLPRYLWCPLLHFIILPTRSPKVAKLYQQVWTEQGSPLMVISKQQRAALEQELKREGVEVPVELAMTYGSPSLDEGWQALKAKGVNRVILLPLYPQYSVSTTASVFDGWAKAMKKERNLPVVRLIRDYHAHPEYIQALAMSVRRHWEQHGQGEHLLMSFHGIPERYEREGDPYGHQCRRTAALLAEVLGLEASQWTASFQSRFGKEEWLKPYTDVTIAGLPATGIKRLDVICPAFAADCLETLEEIQVQNREIFMAAGGEQFEYIPALNSDQAHIRMMVSLICRELA
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAV2_MUNMU
Sequence: MGLETEKADVQLFMDDDSYSRHSSVDYADPDKFVDPGSDRDPHRLNSHLKVGFEDVIAEPVSTHSFDKVWICSHALFEMSKYVIYKFLTVFLAIPLAFAAGILFATLSCLHIWIIMPFVKTCLMVLPSVQTIWKSVTDVVIAPLCTSVGRSFSSVSLQLSHD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin. Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane (By similarity).
Protein: ETFB_SYNWW
Sequence: MNLKVLVCVKQTFDTEAKIELKDGKIADAGINLIINPYDEVAVEGAIQLKEKGVAKEIVVVAAGSDKAMDAIRTALAMGADRGILVQQDTAADEFARAVALAEAIKGENPDIILAGHVAADDGSSQVPTRVAEILGLPHVNVITAVEIAGGKATCTSEADGGTQVTEVSLPAVISSQVSWNEPRYPSMKGIMAAKKKPVATAAAAAAESKVKILEFSLPPAKAAGIKIEDEPEVCATKLAEWMKNTVKVEVK
What is the function of this protein?
Part of an electron transfer flavoprotein involved in syntrophic growth of S. wolfei with butyrate.  Probably receives electrons from butyryl-CoA dehydrogenases, and transfers them to the membrane-bound quinone oxidoreductase Swol_0698.
What are the official names of this protein?
Electron transfer flavoprotein subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF3_RANMC
Sequence: MPRSRINGNFIDKTFSIVANILLRIIPTTSGEKEAFTYYRDGMSAQSEGNYAEALQNYYEATRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAIRQGDSEIAEAWSDQAAEYWKQAIALTPGNYIEAHNWLKITRRFE
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: CYSK_HAEIN
Sequence: MAIYADNSYSIGNTPLVRLKHFGHNGNVVVKIEGRNPSYSVKCRIGANMVWQAEKDGTLTKGKEIVDATSGNTGIALAYVAAARGYKITLTMPETMSLERKRLLCGLGVNLVLTEGAKGMKGAIAKAEEIVASDPSRYVMLKQFENPANPQIHRETTGPEIWKDTDGKVDVVVAGVGTGGSITGISRAIKLDFGKQITSVAVEPVESPVISQTLAGEEVKPGPHKIQGIGAGFIPKNLDLSIIDRVETVDSDTALATARRLMAEEGILAGISSGAAVAAADRLAKLPEFADKLIVVILPSASERYLSTALFEGIEG
What are the official names of this protein?
Cysteine synthase, CSase, O-acetylserine (thiol)-lyase, OAS-TL, O-acetylserine sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: LIPB_COXBN
Sequence: MNDVIIRQLAHLIPYQPLWEAMQTFTARRQSQTTDEIWFLEHEPVFTQGLAGKPEHILNSGNIPLIRTDRGGQVTYHGPGQLMMYLLLDLNRLGLSTRTFVRTIENTVAESLQEWGIPAQGKETAPGVYVDDKKICSIGLRVRKGFSYHGLALNVAMDLTPFSCINPCGFKGLMMTQIQDYVNPIEMDAVKRTIIPLFLKNFGYNQPAIMVETSLEFLIDDHLRSFSEKLGERETVTNSRQN
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GARL_ESCF3
Sequence: MNNEVFPNKFKAALAAHQVQIGCWSALANPISTEVLGLAGFDWLVLDGEHAPNDVTTLIPQLMALKGSISAPVVRVPTNEPVIIKRMLDIGFYNFLIPFVETKEQAINAVAATRYPPEGIRGVSVSHRANMFGTVPDYFVQSNKNITILVQIESQLGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGNASHPQVQKAIQHIFARAKANGKPSGILAPVEADARRYLEWGATFVAVGSDLGVFRTGTQRLADSFKK
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
What are the official names of this protein?
5-keto-4-deoxy-D-glucarate aldolase, KDGluc aldolase, KDGlucA, 2-dehydro-3-deoxy-D-glucarate aldolase, 2-keto-3-deoxy-D-glucarate aldolase, 5-dehydro-4-deoxy-D-glucarate aldolase, Alpha-keto-beta-deoxy-D-glucarate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
Protein: TCPG_MOUSE
Sequence: MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMISTLKKISTPVDVNNREMMLSIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQESCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.  The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.  As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.  The TRiC complex plays a role in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit gamma, TCP-1-gamma, CCT-gamma, Matricin, mTRiC-P5.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIM9_NEUCR
Sequence: MDGLTAAESRELDQRLQKRQVKEFMSVFGNLVDNCFTACVDDFTSKALSGRESGCISRCVLKSMSTQTRLGERFGELNAAMTAEMQRR
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim9.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: CHLL_CHAVU
Sequence: MKIAVYGKGGIGKSTTSCNISIALARRGKKVLQIGCDPKHDSTFTLTGFLIPTIIDTLQSKDYHYEDVWPEDVIYKGYGEVNCVEAGGPPAGAGCGGYVVGETVKLLKELNAFYEYDVILFDVLGDVVCGGFAAPLNYADYCIIITDNGFDALFAANRIAASVREKARTHPLRLAGLVGNRTSKRDLIDKYVEACPMPVLEVLPLIEDIRVSRVKGKTLFEMAETDSSLEYVCDYYLNIADQILSQPEGIVPKEIPDRELFTLLSDFYLNININSNNLEKNESSFLII
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CR3AA_BACTD
Sequence: MNPNNRSEHDTIKTTENNEVPTNHVQYPLAETPNPTLEDLNYKEFLRMTADNNTEALDSSTTKDVIQKGISVVGDLLGVVGFPFGGALVSFYTNFLNTIWPSEDPWKAFMEQVEALMDQKIADYAKNKALAELQGLQNNVEDYVSALSSWQKNPVSSRNPHSQGRIRELFSQAESHFRNSMPSFAISGYEVLFLTTYAQAANTHLFLLKDAQIYGEEWGYEKEDIAEFYKRQLKLTQEYTDHCVKWYNVGLDKLRGSSYESWVNFNRYRREMTLTVLDLIALFPLYDVRLYPKEVKTELTRDVLTDPIVGVNNLRGYGTTFSNIENYIRKPHLFDYLHRIQFHTRFQPGYYGNDSFNYWSGNYVSTRPSIGSNDIITSPFYGNKSSEPVQNLEFNGEKVYRAVANTNLAVWPSAVYSGVTKVEFSQYNDQTDEASTQTYDSKRNVGAVSWDSIDQLPPETTDEPLEKGYSHQLNYVMCFLMQGSRGTIPVLTWTHKSVDFFNMIDSKKITQLPLVKAYKLQSGASVVAGPRFTGGDIIQCTENGSAATIYVTPDVSYSQKYRARIHYASTSQITFTLSLDGAPFNQYYFDKTINKGDTLTYNSFNLASFSTPFELSGNNLQIGVTGLSAGDKVYIDKIEFIPVN
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of Coleoptera.
What are the official names of this protein?
Pesticidal crystal protein Cry3Aa, 73 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryIIIA(a).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: T131L_HUMAN
Sequence: MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIEPLPNVVELWQAEEGELLLPTQGDSEEGLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSYGVLSYHVSGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIASFTCKATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSVVLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSATALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV
What is the function of this protein?
Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6.  Regulates thymocyte proliferation.
What are the official names of this protein?
Transmembrane protein 131-like.
What is the protein family that this protein belongs to?
Belongs to the TMEM131 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum. Note=Transmembrane localization is essential for Wnt signaling inhibition. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. Note=Scattered throughout the cytoplasm in small-sized punctate structures.
Protein: YODC_BACSU
Sequence: MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNLQHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGYITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKEQFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL
What is the function of this protein?
Putative nitroreductase that may contribute to the degradation of aromatic compounds.
What are the official names of this protein?
Putative NAD(P)H nitroreductase YodC.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_SHEON
Sequence: MQEQYNPSEIEALVQKHWHDTKTFEVTEDQNKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVVARFQRLQGKNVLQPIGWDSFGLPAENAAINNKTAPAPWTYQNIEYMKNQLKLLGFGYDWSREIATCTPEYYRWEQWFFTKLYEKGLVYKKTASVNWCPNDETVLANEQVQDGCCWRCDTPVEQKEIPQWFIKITAYAEELLNDIDTLDGWPEQVKTMQRNWIGRSEGVEMTFGVAGSDKSFDIYTTRPDTLMGVTYVAIAAGHPLAEIAAQTNPELAAFIDECKNSTTSEAELATMEKRGVATGLYAIHPITGKQVPIWAANFVLMNYGTGAVMSVPGHDQRDYEFAKKYHLPIEAVIKPAEGDLDISEAAYTEKGILFNSGEFDGLDFDGAFNVIANKLVAEGKGKRQVNYRLRDWGVSRQRYWGAPIPMVTLADGTVIPTPEDQLPVILPEDVVMDGIQSPIKADKEWAKTQVNGQDALRETDTFDTFMESSWYYARYCSPQAEQMLDPTKANYWLPVDQYIGGIEHACMHLLYFRFFHKLLRDAGLVNTNEPAKQLLTQGMVLADAFYYTNDKGARVWVSPLDVATTEKDDKGRITKAIDKDGNELVYTGMCKMSKSKNNGIDPQVMVEKYGADTVRLFMMFASPPELTLEWQESGVEGAHRFIKRLWKLASEYVAQDNSEALDVSKLTSEQKALRREVHKTIAKVTDDIGRRQMFNTAVAAVMELMNHLQKAPQTTGQDRAIIGEALSAVVRLLYPIIPHVSFTLWNELGNTNSIEDSQWPVVDESALVEDSKLIVVQVNGKVRAKITVAADADQASVEALGMADEQVIKYLDGVTVRKVIYVPGKLLSIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAD54_DANRE
Sequence: MRRSLAPSQVAKRKQGPDSDDEEDWEPDMEPQCKRDCREKYISPYRKPLTPLTNRPFCADGNEHEAFIRKILSKPFKIPIPNYTGVLGLRALGLRRAGVRKALHDPFEDGALVLYEPPVISAHDLIKADKEKLPVHVVVDPVLSKVLRPHQREGVKFLWDCVTGRRIENSYGCIMADEMGLGKTLQCITLIWTLLKQSPDCKPEIDKVIVVSPSSLVRNWYNEVGKWLGGRVQPVAIDGGSKDEIDSKLVNFISQQGMRIPTPILIISYETFRLHAEVLHKGKVGLVICDEGHRLKNSDNQTYLALNSMNAQRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAQEFKKRFEIPILKGRDADASDKDRAAGEQKLQELISIVNRCLIRRTSDILSKYLPVKIEQVVCCNLTPLQKELYKLFLKQAKPVESLQTGKISVSSLSSITSLKKLCNHPALIYEKCLTGEEGFDGALDLFPQNYSTKAVEPQLSGKMLVLDYILAMTRTTTSDKVVLVSNYTQTLDLFEKLCRNRRYLYVRLDGTMSIKKRAKIVERFNNPSSPEFIFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSTGTIEEKILQRQAHKKALSSCVVDEEQDVERHFSLGELRELFSLNEKTLSDTHDRFRCRRCVNGRQVRPPPDDSDCTCDLSNWHHCADKRGLRDPVLQASWDAAVSFVFHQRSHEDQRGVV
What is the function of this protein?
Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:30961891).  Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism.  Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized.  Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity).
What are the official names of this protein?
DNA repair and recombination protein RAD54-like.
Protein: CYB_BERBI
Sequence: MINIRKTHPLMKTINNAFIDLPTPSNISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTTTAFSSVAHICRDVNYGWIIRYLHANGASMFFICLYAHVGRSLYYGSYTFQETWNIGVILLFTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIILTLAAVHLLFLHETGSNNPTGIPSNMDKIPFHPYYTIKDILGALLLILALLTLTLFAPDLLGEPDNYTPANPLSTPTHIKPEWYFLFAYAILRSVPNKLGGVLALLLSILILLFIPLLHTSKQRSMMFRPFSQFFFWLLIADFLTLTWIGSQPVEYPYMTVGQLASILYFLLILVLMPMAGLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: H1A_PLADU
Sequence: ARRRKTAAAAHPPVATMVVTAILGLKERKGSSMVAIKKYIAANYRVDVARLAPFIRKFIRKAVKQTKGTGASGSFRVNKTAVPKKKKAAKKPKAKKVKKPKSAAKKKTNRARKPKTKKNRN
What is the function of this protein?
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
What are the official names of this protein?
Histone H1A, sperm.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.