PharMolix/UniProtQA huggingface dataset:
Protein: RK20_TRICV
Sequence: MARVKRGNIARKRAKKILQLAKGYRGAHSRLFRIANQQVMKALRYSYVGRKQKKRVFRKLWITRINAASRLNGLSYSRLIHNFKKSNIELNRKMLSQIAVLDIPTFNQLIAISK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: WLS_RAT
Sequence: MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVSYVAAKCVDVRKNHHKTRWLMPWGPNKCNKINDFEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQIDIAFKLNNQIRENAEVSMDVSLGYRDDMFSEWTEMAHERVPRKLRCTFTSPKTPEHEGRHYECDVLPFMEIGSVAHKYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE
What is the function of this protein?
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism.  This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins.  Also plays an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
What are the official names of this protein?
Protein wntless homolog, Integral membrane protein GPR177, Protein evenness interrupted homolog, EVI.
What is the protein family that this protein belongs to?
Belongs to the wntless family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: RS23_ICTPU
Sequence: MGKCRGLRTARKLRDHRREQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS
What are the official names of this protein?
40S ribosomal protein S23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: AROA_RUEST
Sequence: MSGHGTPIPMTSRRASPLKGEAHVPGDKSISHRSLILGAMAVGETKISGLLEGEDVLDTAKAMQAFGAEVVNHGGGEWSVFGVGVGGFAEPENVIDCGNSGTGVRLIMGAMATSPITATFTGDASLNKRPMARVTDPLALFGAQSVGREGGRLPMTIVGAAEPVPVRYEVPVPSAQVKSAVLLAGLNAPGKTVVIEREATRDHSERMLAGFGAEITVEDTKEGRVITLTGQPELKPQVIAVPRDPSSAAFPVCAALITPGSDVLVPGIGLNPTRAGLFYTLQDMGADLTFENPRTEGGEPVADLRAKYSPDMKGIEVPPERAASMIDEYPVLSVVASFATGTTMMAGVKELRVKESDRIDAMAKGLRANGVTVEEGEDWWSVEGCGPEGVKGGGTAESFLDHRIAMSFMVMGMGAQNPVSVDDGSPIATSFPIFERLMGDLGASIIRTDG
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WOR2_CANAL
Sequence: MTQLPSVSELINRTGSIGSSSNITRVPPMTTTSATNTTTAATATTVTSTTPRSENSYSPNSPYSLPTRPSNTSLTNYSAGSGITVASSSFQFSQPSPGRSKHNSTSSQSSSGDSFQQHQSNPSGVSMSSNTSPRTSIVQSMSSVPTPPSTGPAPQQFVYQESQLPVQPPPQQQQLQQPPPPPPQQQQHIYPQQQPNFPYHNNFVSPPTYTTAYPQYYYQPVMTPPHHQPHQQAPIHLANNVSILQSQAVMQNAYPTTHYLQHVGPHHIYANVNSQVYYQDMAREEANKALINKRRIIKRRTRTGCLTCRKRRIKCDERKPTCFNCERSKKSCLGYQDLSKLPPRKRNRDTSLDLPDGNQQQQQQQQNQQSIVGGAGNVSDEPHNETHQITSISGSSTNSRNLDMMIPQSFRNNISSQPINFYGPVATTASGASAVINRVSVADLLK
What is the function of this protein?
Transcriptional regulator of the switch between 2 heritable states, the white and opaque states.  These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence.  Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency.  WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating.  Plays a role in cell adhesion and pseudohyphal growth.
What are the official names of this protein?
White-opaque regulator 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: CROE_ECOLI
Sequence: MKAYWDSLTKEQQGELAGKVGSTPGYLRLVFNGYKKASFVLAKKLEQYTSGAITKSDLRPDIYPKD
What are the official names of this protein?
Prophage transcriptional regulatory protein, Putative lambdoid prophage e14 transcriptional regulatory protein.
Protein: UREG_MYCBO
Sequence: MATHSHPHSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAALCRQLRGELSLAVLTNDIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITANLDAIDELMAAHDALDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDKVPRKGGPGVTYSDLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQSLTEDPAASDVVAWVRSQLAADGV
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_SALAR
Sequence: MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLANELERWKQDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMC4_HUMAN
Sequence: MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEEILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVAVNPKEIASKGLC
What is the function of this protein?
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.  The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
What are the official names of this protein?
Structural maintenance of chromosomes protein 4, SMC protein 4, SMC-4, Chromosome-associated polypeptide C, hCAP-C, XCAP-C homolog.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC4 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Protein: MIAA_CROS5
Sequence: MSRGLIVICGATATGKTALALEIAQSLNSIIISADSRQVYREFDIGTAKPTPAEQDLIPHYLIDICDPRETLTLAEYQEKAQSLIDKNLTNFPLLVGGTGLYIKSIVKGLKIPRVAPQPRLRFQLEALGQQQCYQILQQVDTISSQKIHPNDQVRTLRALEVFYVTGIPISQQQGENPPTYPIVQIGLDCSTEELKRRIEIRTKKMLEMGFVEEVEKLVKKYGWELPLFKTLGYAEILNYLQGKLSLSEAEREIILHTRQFAKRQRTWFRAYPEIEWFDTTSPDLVENVFSKLTETLGLLN
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: GLYC_LASSG
Sequence: MGQIVTFFQEVPHVIEEVMNIVLIALSILAILKGLYNVATCGLIGLVTFLLLSGRSCSLIYKGTYELQTLELNMETLNMTMPLSCTKNNSHHYIRVGNETGLELTLTNTSILNHKFCNLSDAHKRNLYDHSLMSIISTFHLSIPNFNQYEAMSCDFNGGKITVQYNLSHSFAVDAAGHCGTLANGVLQTFMRMAWGGSYIALDSGRGNWDCIMTSYQYLIIQNTTWDDHCQFSRPSPIGYLGLLSQRTRDIYISRRLLGTFTWTLSDSEGNETPGGYCLTRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIRRLKTEAQMSIQLINKAVNALINDQLIMKNHLRDIMGIPYCNYSRYWYLNHTSTGKTSLPRCWLISNGSYLNETKFSDDIEQQADNMITEMLQKEYIDRQGKTPLGLVDLFVFSTSFYLISIFLHLVKIPTHRHIVGKPCPKPHRLNHMGICSCGLYKQPGVPVRWKR
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1.  The glycoprotein spike trimers are connected to the underlying matrix.  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm.  Membrane fusion is mediated by irreversible conformational changes induced by acidification.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: MSRP_SALSV
Sequence: MKKIRPLTEADVTAESAFFMQRRQVLKALGISAAALSLPSTAQADLFSWFKGNDRPKAPAGKPLEFSQPAAWRSDLALTPEDKVTGYNNFYEFGLDKADPAANAGSLKTEPWTLKISGEVAKPFTLDYDDLTHRFPLEERIYRMRCVEAWSMVVPWIGFPLYKLLAQAQPTSHAKYVAFETLYAPDDMPGQKDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPIRLIVPWKYGFKGIKSVVSIKLTRERPPTTWNLSAPNEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYANEVASLYRGLNLRENF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: Y490_CLOB8
Sequence: MESSLKIKDIPQNERPKEKLLTYGAESLSNSELLAIIIRTGTQGENVLQLCSRLLSELEGLNGILDASFDDIISIKGIKQGKASQILALAELFKRFRTLKAINNDIKITSPKDLASLLMGEMNELNQEVLKVVLLNTKNIVVGIKDVFKGSLNTSVVHPREIFKQAISKNSASIIICHNHPSGDPTPSREDINITLRIKECGNIIGIQLVDHIIIGNNKFVSLKERGLI
What are the official names of this protein?
UPF0758 protein Cbei_0490.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: GT2_ORYSI
Sequence: MGQEGMGYNNGKGGGGGGGGLPMTAPRPRGASPLSSHGHHHRSRKIHRTFNNVKITVLCGLVTILVLRGTIGLNLSLPNQPTDADALAGAKAVEDIDRILREIRSDGGADDDAAAAGDLAGSFNATALNATEAAAAYASAVERYALGPKISDWDGQRRRWLRQNPGFPSTVAGGKPRILLVTGSQPGPCDNPLGDHYLLKTTKNKIDYCRLHGIEIVHNLAHLDTELAGYWAKLPLLRRLMLSHPEVEWIWWMDSDALFTDMAFELPLSRYQDRNLIIHGYQDLLFEKHSWIALNTGSFLFRNCQWSLDLLDAWAPMGPKGFIRDEAGKILTANLKGRPAFEADDQSALIYLLLSQKEKWMNKVFIENSYYLHGFWAGLVDKYEEMMENHHPGLGDERWPFVTHFVGCKPCGSYGDYPVERCLRSMERAFNFADNQVLRLYGFAHKGLESPKIKRVRNQTTKPIDDKENLDVKAKISTTS
What is the function of this protein?
Probable glycosyltransferase that may be involved in the biosynthesis of xyloglucan.
What are the official names of this protein?
Probable glycosyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 34 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: RS11_ROSCS
Sequence: MAKQSAKGSTTTKRQRGKRREKKNVPRGQAHIQSTFNNTIVTITDPNGNVVCWSSAGQNGFKGSRKSTPYAAQIAAENAARKAIENGMRQIEVFVKGPGAGREAAIRSLQAAGLQVTAITDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: OSB4_ARATH
Sequence: MQFLGRSISKSIRPSLNSTARKSWVLSSQQFLSTSSTESSSRTRGGGGGNRAEKSSEEWPRPMEVPYQPKIANSIDLIGYVHQPVQFDSTLDGKFWAGTVISHEPSSDSKSESDSSSNFWIPVLFEGDLAHTANSYLKKNDRVHITGQILGDVIQSGANSDQAHVQLFKSFHGSFSHQVMVRDLHYIEGSKAMPKVLPTLDQNEGVLKHSASVQRGREFGTNLWFDLVDKPNEWCDYREMKQNGSVNPKHPDFKKKDGSQALWLNNAPTEILSELKDVKFDIPKYAKQPKAGEESWKDLVDNMNKWWDNRVDKRTPKSPDFKHKETGVGLWLSDSPSWVLEKLPPPKSKTSDIYGVQEMF
What is the function of this protein?
Binds single-stranded DNA.
What are the official names of this protein?
Protein OSB4, chloroplastic, Organellar single-stranded DNA-binding protein 4.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TPX_LISIN
Sequence: MTQVTFKHNPVTLVGTERKVGDKAPNFTVVNRDLEEVTLHDYDGKVRLISVVPSIDTSVCSTQTRKFNEEASNLDNTVVLTISVDLPFAQKKWCAAEGLPNAITLSDHRDLSFGEAYGVIMKELRLLARSVFVVNAKGEIVYTEVVPEGSDHPNYEAAIEAAKKA
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: MRAZ_LEUCK
Sequence: MFMGEYSHTLDVKGRLIIPAKFRNQLGEKFIVTRWMEHALRAMPMPVWEKLEQQLNQLPLGKKEARQFKRFVMAGAMEAEIDKQGRIIIPSNLKTYAGLAKNVIVTGSGDSFEIWSDENWQSYTAETAENFDDIAEGLVDFDF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ISPF_SYNJA
Sequence: MRIGQGYDIHRLVEGRPLILGGIRIPYEKGLLGHSDADVLTHAIMDALLGAAALRDIGYYFPPEDERWKGADSILLLQQVVQLVGQEGWRIANVDSVVVAEQPKLKPHIPAIQARLAEAMQLSPKQVGVKATTNEKLGPVGQGEAMAAFAVVLLLER
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: YIDC_BACFR
Sequence: MDKNTITGLVLIGILLVGFSFLSRPSEEQIAAQKRYYDSIAVVQQQEEALRAKTEAALANEKEETAADSASLFFNATKGKEAFTTIQNNLVEITLDNKGGRVYSALLKNYMGQDKKPVVLFNGSDASMNFNFYNKKGALQTKDFYFEAVNKTDSSVTMRLAADSASYIDFIYTLKPDNYLMSFVIKATGMDGKLAASTNYVDISWSQRARQIEKGYTYENRLADLTYKYTGDDVDNLSASKDDEKSVSERLDWIAFKNQFFSSVFIAEQDFEKTTVKSKMEKQGSGYIKDYSAEMSTFFDPTGKQPTDMYFYFGPNHYKTLTALDKGREEKWELNNLVYLGWPLIRWINKWITINVFDWLSGWGLSMGIVLLLLTIMVKIVVFPATWKTYMSSAKMRVLKPKIDEINKKYPKQEDAMKKQQEVMGLYSQYGVSPMGGCLPMLLQFPILMALFMFVPSAIELRQQSFLWADDLSTYDAFITFPFHIPFLGNHLSLFCLLMTVTNILNTKYTMQQQDTGAQPQMAAMKWMMYLMPIMFLFVLNDYPSGLNYYYFISTLISVVTMIILRRTTDENKLLTELEAKKKDPKQMKKTGFAARLEAMQKQQEQLAKERANKQNKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DPO4_FRATN
Sequence: MTKLRKIIHIDMDYFFAQVEEKANPSLKDKPFAVGGTNPKRGVISTCNYIAREYGVRSAMPTAIAMQKCPNLILLNTDFAKYKAASAVIRDIFYSFTDKVEPLSLDEAYLDVTDVKEYKNSATLIAQAIKQEIFNKTGLTGSAGVAPNKLLAKIASDINKPNGLYVITPEQVDSFVKDLPVKKLFGVGKVSQEKLKTMNVETCLDLQQLSLATLLDKFGKFGNNLYSYARGIDNREVNPVRIRKSVSVENTYLEDLKTLNACLEKLPSLYDKLTSRMTEEHYKSIVGIVVKFTDTKFNKTSLTRVAKTLDKEAIKSLIIELYQKQNHPIRLIGIGVKLGEVEDRQMKLF
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDK12_MOUSE
Sequence: MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDVGLVTPEAASLGTIIKPLVEYDDISSDSDTFSDDTAFKSDRRENEERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRVSGSSKRSVEGSDDYGKAQLSKSGSKESRSSKMHKEKTRKERELKSGYKDRSKSHRKRETPKSYKTVASPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKSSPIILPKKEKLEVKESGLESKKLPRSIKSEKSTPDTELVTVAHSNPEVKHCLDTGKVRLDENLQKHPAKDLKAQGTKDVKPVAPKEVIVTSKETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQPPLPPPQPPFSQVPVSSTSILPSSPHPRTSTLSSQTNSQPPVQVSMKTQVSITAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGIVIEDPPPSKASRKETTSGTTAEPVKNNSPAPPQPAPVKAEPGPGDAVGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEASSQQQDSESIAPEESLKEVPSVPVVLPPAEQTTPEASNTPADMQNVLAVLLSQLMKTQEPAGNLEENTNDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRSHPNRTYGNTDGPETGFSSADTDERSSGPALTESLVQTPVKNRTFSGSVSHLGESNSYQGTGSVQFPGDQDLRFTRVPLALHSVVGQPFLKSEGNSNSVVHAETKLQNYGELGPGTTGANSSGTTLQWGGPAQSYGKPYRGAARVLPRGGRGRGVPY
What is the function of this protein?
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation.  Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.  Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'.  Required for RNA splicing, possibly by phosphorylating SRSF1/SF2.  Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
What are the official names of this protein?
Cyclin-dependent kinase 12, Cdc2-related kinase, arginine/serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, Cell division protein kinase 12.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.
Protein: SCRB_FUSMR
Sequence: MDKKEYINRLNEQKPLQEMXSRDRYLXNFHLIP
What are the official names of this protein?
Sucrose-6-phosphate hydrolase, Sucrase, Invertase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 32 family.
Protein: PAND_SALAR
Sequence: MIRTMLQGKLHRVKVTQADLHYEGSCAIDQDFLDAAGILENEAIDIWNVSNGKRFSTYAIAAERGSKIISVNGAAAHCASVGDIVIIASFVTMSDEEARTWHPNVAYFEGDNEMKRTAKAIPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.