PharMolix/UniProtQA huggingface dataset:
Protein: MURC_WOLWR
Sequence: MRILNYTIINLVMSKHLLLNINKTQKGIIHIIGIGGIGMSAIAEILHNSNYKVQGSDAQSNNNVDRLQKLGIEVYIGHNANNISQAQIVVHSSAIESDNVELVTARNNNKTILHRSDILAELLRDKYVIAVSGSSGKTTTTAMIASIFDHSNIDATVIVGGILNSYQSNSRLGKSDIFLIEADESDGTMLKIPANITVITSINDDHMDHYGTFDDIKHAFSQFINKADFAILPDSVGINYDASNSMMFGFESGNIRASNIKQHANSIEFDVLIDNNHRIKNVVLSNTIGMHKVSNALAAISVAIKLGISDAEIKKGLLEFQGVARRFSLIADIKGVKLIEDYAHHPNEIYATLTAARSITKGKVIGIIEPLRFARIRNFFDEFIRIFMMFDYVILTPVHPPEDKPIPGCGIDDIQKALISNGFNNTKIMNDALLISHFISDSTSPSDIVLFIGAGSNIAKLAKETAALIAEVKV
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_METBU
Sequence: MTTANIIDLSGNSKGEIALPEVFSEIFRPDLIKKAVLSAQANRLQPYGTKLYAGMQTSAHSWGSGRGVAQVPRISNGSRVARIPQAVGGRRAHPPKTETDRTEKINKKEKRLAVRSAIAATIDADLVKARGHKFTAEVPFVADDAIEGLVKIKEVISFLQAAGLYDDIIRAKEGKHIRAGKGKRRGRKYKNRKSVLIVTGEESLLSKAANNLPGVDVATVTALNAELLAPGTHAGRLTVWTQSAITNMEGMFL
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TTRR_SALTY
Sequence: MATIHLLDDDTAVTNACAFLLESLGYDVKCWTQGADFLAQASLYQAGVVLLDMRMPVLDGQGVHDALRQCGSTLAVVFLTGHGDVPMAVEQMKRGAVDFLQKPVSVKPLQAALERALTVSSAAVARREIILCYQQLTPKERELASLVAKGFMNREIAEAMNIAVRTVEVHRARVMEKMQAGSLAELIRRFEKMASPETRIRTTYEP
What is the function of this protein?
Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase.  Positively regulates transcription of the ttrBCA operon.  During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S. typhimurium over the competing microbiota in the lumen of the inflamed gut.
What are the official names of this protein?
Tetrathionate response regulatory protein TtrR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_PARDP
Sequence: MTGNLRTFILMAALTALVMGMGGLIGGRGGAVIALAIAGAGNLFAWWNSDKMVLRQQGAHLVTRQQAPELVDMVAALAQRANLPMPKVYVLETEQPNAFATGRNPENAAVAVTQGIMRVLNRDELAGVIAHELAHIKHRDTLTMTVTATMAGAIAMLGNMLMFSSMFGGRDDNRGSGLAAILAMIFAPMAAGLVQMAISRTREYEADRMGAEICGRPMALAGALAKISRAAGQVVNIPAERNPASASMFIVNPLHALRMDRLFATHPPTEERIARLQAMASGAPASGPWGAR
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS2_MYCS5
Sequence: MNTKKEEVVSSPEATVEKKQTQSQTPIVSRDKLLEAGAYFGHKKQMWHPKMKEFIVPKRLNKNAHIIDIVKTQKYLEFAYSLVEKLAAKGVSFIFVGTKRQAKKTVKEAAERTNSLYVSERWLGGTLTNNSVIMKRVQKMNELDKKAEQGFKGYTKKEALLLQKQLDKLHQNLDGIKNMRRLPQVMIVTDLVEDKIAIQEAKKKKIKIIGIVDTNVDPTVIDFGIPANDDSSKSINLIVNILADAIAKTQGKKQMYAYQPDDKIVLSNPHELKKSEEASEVKAASTKEKLTEEASQ
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SYA_THEPD
Sequence: MSKEDFVNLPFFVENGWIKRTCPVCGRTFWTLDPERKVCGDQPCEEYSFIGRSVGVKPESLSATRKMFIDFFEKRNHTPVKRYPVVARWREDVYLVGASIYDFQPWVTEGLVPPPANPLVISQPSIRLTDLDNVGKTGRHLTGFEMMAHHAFNIRDQRVYWANETVEYAFEVLTKVYGVKPEEITFIFDMWSGGGNAGEDYEVIVRGLEVATLVFMHYKTAEDGSLIPIENRIVDTGYGLERIYWLLTGHYNVYEAVFSGVIDRLRKLSGVEKPPDDLMYRLALKSGRLDFKKPLEALETLRNVSREVGISFEELQRVLEPNEALYALADHTRTIAWMLGDGVVPSNSGAGYLARLLIRRSLRLLRRLQLELPLSEIVLWQIQYWRNDFPEYLELQDEIRDIVDTEEERFEESVKRGEKVLGALLGELKSKGLRVVPAEEIVKLYESHGVPPELVKEKAESEGLEADITGFYSRLAEMRSRAQVQQKEALQLPLDPSRLKEFRPTRLLYYENEKLAEFEATVLGVLDGKYVVLDSTAFYPEGGGQLSDTGVLVYEGGECRVKYAFKVGDIVVHECEGNAPPVGARVKGVVDMERRLALMRHHTATHIVLGALRSVLGKHVWQAGAQKTPDYVRFDFTHHKAITPEQAKAIEALANRVVMEDRPVRKYLLNRTEAEKAFGFTLYQGGAVPQTTLRVVEIPGWDAEACGGTHCDRTGEIGLIKILGFEKIQDGVVRVVFKAGMPALEYVQGMGDKLKNLQEILDASYEGLEEKAKSLKSRIEALEKEVKKLREELLKGGVSVSPVATVQGVQVYVYFSDEYEPREAALAISRTRTSSVILAYNSKGNFALKVTDDLLDRLDAREIGRSVCESLRGKGGGVRDLYQGRIDETKSVDKVIVEALRQALERR
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOT1L_DROME
Sequence: MATPQVKDLVLRSPAGSSDVISFAWPLQIGHGQDKHDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTACYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHILQLVYNAAVLDPDKLNQYEPFSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYAERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADLRDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERYFQRLKTKGGNDHESVGTVRTTRDRAKREANVGQHHHNNHHSNNHANSNNHQRDREQSNGATATAAHQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGNTTTATNTTSASNGPMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGRQARATTQKKRKKLTRKAAIASKSAAAAQREAEAAAAAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGARGRKSLKIVGLEALHKQTVLSTSLDTMTKKLPAAPGTVDQQLTALLTENMSHAELDIPTAPQDTPYALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQEQERMARLKNRASQLDKQIKVLIDDSVALLKVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLLNKQLKNLPEYQKLCGTVNGKVKLEVPPELSETTAQELVLKEIANTLSQRKKLYAQVSTIEQETSVLQKTAEERSTAATLLAQGTNMIVSTGSSSSSSTTVCASAVTAQSNKLNSVKNSRRNREHRARSQEWPEVPEVGKIQESNPEVLAQKIVETCRQIEAGKFQGAGAPSSQVNGKNKAIIEVPPPPATAPVSIKSSPGHHYKDTTLMPAPKQQQQQQMTLSQLPKCELPGLSTSRKQESPKVANFEDRLKSIITTALNEDQEQRSKAVESSPSPSPLHSPAPKRSKQHPAGAINPAQSLPNNLHNIITVSTQGLMHLNANTTISPITPPLPGPGAGATASTAPPPPANLPYGAYGGAVAKTTISGKYQAAKEPKYSPVRQAPLPPPPSHMASLYPAGQQTTPADLGYQRRRSSVSATSYEHYMVQQQQQLQQQQLMLAAAAHAAQRQQMRVEEQQQQQQHQHHHHHHHHHPQHRLPQHVQHQHPHQHHPNEFKAPPADSHLQRSSSREQLIVEPPQTQPLELLPRASSANSDYSGYRIRPPSRPSSNSSQPDYTQVSPAKMALRRHLSQEKLSQHVTPQATPPLPGHGGAPTSGKTIGDLVNGEIERTLEISHQSIINAAVNMSTSGASFMERAFLNERSNDRLLINLNAQRPERVHVRPLSEESQDPQPTSYAQERGPGLGAGGAAAGGNSNLATLAHVAYAQKAQGGARANAGTAPPATHSSSARSGRDYQPVALPRAELKGSIEAYFHEEQQQKQSKGAGSAGSSSLRGPRLNGANPPLEGLAASLQDHVRARKYKEETEERQRRAAAAASSSAGPPAGMELPTHYAHQAPPAHSYHHHGASINGTPHKVELGIKRSSPLAPHQQPPRPSKLAHYEPPTTQQQHAHAHLYANGQVLPPPPAHDATTPSPTPSSSSSSCGRRSNSNNGKLLVDPPLLMSPEINSLLGDERPLQLSHHQQQQQQMLHHHQSQQQQHLQLTQQQLRVAHLGHGLSHGHSTMPTLGGQRNGNGNAADDVNDLATQRTITNYDPRRRLRTTLSGPTKLSAAHSNQNLNGYVMADSSSSCPTIPQ
What is the function of this protein?
Histone methyltransferase.  Methylates 'Lys-79' of histone H3.  Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression.  Also involved in telomeric silencing but do not in centric heterochromatin.  Probably participates in pairing sensitivity.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-79 specific, DOT1-like protein, dDOT1L, Histone H3-K79 methyltransferase, H3-K79-HMTase, Protein grappa.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPD_SALNS
Sequence: MQQLQNVIETAFERRADITPANVDTVTREAVKQVISLLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIDGAESRYFDKVPMKFADYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYLGQSTKIYDRETGEVHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MERT_SERMA
Sequence: MSEPQNGRGALFTGGLAAILASACCLGPLVLIALGFSGAWIGNLTVLEPYRPIFIGAALVALFFAWRRIYRPAQACKPGDVCAIPQVRATYKLIFWVVAALVLVALGFPYVMPFFY
What is the function of this protein?
Involved in mercury resistance.  Probably transfers a mercuric ion from the periplasmic Hg(2+)-binding protein MerP to the cytoplasmic mercuric reductase MerA.
What are the official names of this protein?
Mercuric transport protein MerT, Mercury ion transport protein.
What is the protein family that this protein belongs to?
Belongs to the MerT family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SIEB_BPP22
Sequence: MNNSWWQELMRFFLQGMTLKQLIHMLIILIVLIIVMPVSVKEWINLHNPEILPHYWMYYILLFCVSYVLNGVVNSVYHAVTERIEASTAQRRKDREEKVVRDLFDSLTLGERAYLAFAVAANNQLKTEKGSPEAISLLKKGIITRLPSAIGYPDIDRFIIPEKYFNECYMRFAGKSDILMNELIVQDEQLKK
What is the function of this protein?
Has a role in the prevention of superinfection by phages that are insensitive to repression.
What are the official names of this protein?
Superinfection exclusion protein B.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: YCIB_PSEA7
Sequence: MKQFIDFIPLVLFFIVYKIDPQNVEFAGFNLSGIYGATATLILASVIVYGALWLKHRHLEKSQWFTLGACLVLGGLTLAFHEDTFLKWKAPLVNWLFALAFAGSHFIGDKPMIQRIMGHAIQLPQGLWVRLNIAWVVFFLVCGFANLYVVFTYPNFWVDFKVFGSLGMTLLFLIGQGIFLARHLHDADTGEKPKD
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSPN_BACC1
Sequence: MGNPKKNSKDFAPNHIGTQSKKAGGNKGKQMQDQTGKQPIVDNG
What are the official names of this protein?
Small, acid-soluble spore protein N, SASP N.
What is the protein family that this protein belongs to?
Belongs to the SspN family.
What are the subcellular locations of this protein?
Spore core.
Protein: YCIB_AROAE
Sequence: MKILFDLLPVILFFVAYKIAGGNQAFAHELASRWLGDGIAVTQAPILLATAVAILATIAQIGWVWMRHRKVDTMLWISLAIIAVFGGATLFFHNPTFIKWKPTALYWLFGGTLTVSAVIFRRNLIRKMLEAQIRLPEPVWKRLNLAWAGFFILMGFLNLYVAYNFSEEAWVNFKLFGGMGLMLLFVLGQGFYLSRHIQEETT
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SWF1_YEAST
Sequence: MSWNLLFVLLIGFVVLILLSPVFKSTWPFSTFYRNVFQPFLVDDQKYRWKLHLVPLFYTSIYLYLVYTYHMRVESTIKNELFLLERILIVPIIILPPVALGILAMVSRAEDSKDHKSGSTEEYPYDYLLYYPAIKCSTCRIVKPARSKHCSICNRCVLVADHHCIWINNCIGKGNYLQFYLFLISNIFSMCYAFLRLWYISLNSTSTLPRAVLTLTILCGCFTIICAIFTYLQLAIVKEGMTTNEQDKWYTIQEYMREGKLVRSLDDDCPSWFFKCTEQKDDAAEPLQDQHVTFYSTNAYDHKHYNLTHYITIKDASEIPNIYDKGTFLANLTDLI
What is the function of this protein?
Palmitoyltransferase that targets several endosomal SNAREs.  Palmitoylates the SNAREs SNC1, SNC2, SYN8 and TLG1, at cysteine residues close to the cytoplasmic end of their transmembrane domain.  May have a role in the cellular quality control of transmembrane domain-containing proteins.
What are the official names of this protein?
Palmitoyltransferase SWF1, Spore wall formation protein 1.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ARTI_ECOLI
Sequence: MKKVLIAALIAGFSLSATAAETIRFATEASYPPFESIDANNQIVGFDVDLAQALCKEIDATCTFSNQAFDSLIPSLKFRRVEAVMAGMDITPEREKQVLFTTPYYDNSALFVGQQGKYTSVDQLKGKKVGVQNGTTHQKFIMDKHPEITTVPYDSYQNAKLDLQNGRIDGVFGDTAVVTEWLKDNPKLAAVGDKVTDKDYFGTGLGIAVRQGNTELQQKLNTALEKVKKDGTYETIYNKWFQK
What is the function of this protein?
Part of the ABC transporter complex ArtPIQMJ involved in arginine transport.
What are the official names of this protein?
Putative ABC transporter arginine-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS11_GLUDA
Sequence: MAKAAAPRIRKKERKNIISGVAHVLSTFNNTMITISDAQGNAIAWSSAGAQGFKGSRKSTPYAAQVAAEDAGRKAREHGMETLEIEVSGPGSGRESALRALQAVGFSITSIRDMTPVPHNGCRPRKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: MEP2_ARTBC
Sequence: MHGLLLAGLAAALPLGVAGLPARQQSGLSPRGIDINPYRFASMAKYSEHKATSQMVHSFSYSKDDDYVATATKLVKSTFPNMTFRTVKDHYIGTNGIGHVHFKQTAHGIDIDNADFNVNIGRDGKVFTFGNSFYEGEMPKTNPLTKRDFSDPVKALHGAIKTLKLPVKPQSAKAMPMKEAETFKFEGTSGALSDPMAKLVYIQKDGKLHLTWRVETDVGDNWLLSYVDSKETETVHNVVDYVASADYKVFAWGLNDPTEGQPTMIKDPWNTTGTGSPFTWHGDGQMDYTVTRGNNIAAQDNPSGGEQWENNYRPDSPELSFVYEYNEQMEPEQYKDFAITQLFYTTNTFHDVLYSLGFTEEAGNFQMNNNGKGGEGNDFAICNAQDGSGTNNANFATPPDGQNGRMRMYTWTTAQPSRDGDLEAGIVIHEYTHGLSNRLCGGPANSNCLTELEAGGMGEGWGDFYATAIRLKQDDTHDTDYTMGEWAANMQGGIREYPYSTNMQTNPYTYADVQGMDEVHGIGTVWATILYEVLWNLIDEHGMSKNIMPKFVNGAPSDGRNLAMKLVLDGMTLMPCNPNFMQARDAIIDADQALTNGQNKCALMKAFSKRGLGANYKHGKTRVNNFDMPADC
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Probable extracellular metalloproteinase 2, Fungalysin MEP2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RBFA_HELMI
Sequence: MAGHRMARMAEEIKRELARLLRDEMKDPRLGFVSITAVEVSGDGRHAKVYVSVMGDESARDNSQAALKQATGFLRTELSKSLRVRYVPELVFLSDLSIERGTRIARLLTEMENHDDAEAPR
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX828_LYCSI
Sequence: MKLMIFAGLVLFAIVSLIEAQAEHEKPCLPEYKVCTHAPGNCCSDLVYDCYGRYKSGAQIGRNCFCLQKGVIYKREN
What are the official names of this protein?
U8-lycotoxin-Ls1q, Toxin-like structure LSTX-H28.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 08 (U8-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YIDD_CAUVC
Sequence: MTFYERTVDLGLRAYKLTLSPLIGRQCRFTPSCSEYTAAALKDHGPLKGSWLGLRRICRCNPFGGSGYDPPPPRHQPRKWKCEE
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VG38_BPT2
Sequence: MAIVGVPGWIGESAVNETGQRWMDAAMRAVHVSVPGWMSSMAGQSKEIYLSIGANHNYDRNSLINWMRAQGGAPVVITITGDLVSNSTGNACLEFPSDLPNAYIQLIINSGVTVYGRGGNGSTNSSAGGNGGTAIHNAAGTKLRIRNNGAIAGGGGGGGAASLKNSYPTNGSCGGGGGRPFGVGGKIGSDSILSGSNASLTDAGTGGTTFQYGAGNGGNVGAGGGRGWGKNVYTSEGGAAGAAVTGNAPNWQNVGTIYGSRV
What is the function of this protein?
Vg38 is at the tip of the long tail fibers and serves as the phage recognition site for the cellular receptor.
What are the official names of this protein?
Receptor-recognizing protein, Protein Gp38.
What are the subcellular locations of this protein?
Virion.
Protein: PAK3_MOUSE
Sequence: MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHQSNTKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR
What is the function of this protein?
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation.  Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity (PubMed:25851601).  Acts as downstream effector of the small GTPases CDC42 and RAC1.  Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.  Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.  Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments.  May also be involved in early neuronal development.  In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (PubMed:15800193).
What are the official names of this protein?
Serine/threonine-protein kinase PAK 3, Beta-PAK, CDC42/RAC effector kinase PAK-B, p21-activated kinase 3, PAK-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_LILLO
Sequence: MEELQGYLKKDRSPQQHFLYPLLLQEYIYTLAHDDSLNGSIFYEPIEFIGYDNKFSLVLVKRLIIRMYQQNFLIYLVNDSNQNRFGGHTNSFYSHFFYSQMVSKGFSVIVEIPFSLRLVSSSEEKEIPKSQNLGSIHSIFPFLEDKLSHLNNVSDILIPHPIHFEILVQILQCWIQDVPSLHLLRFFLHKYQNLNKTIQSNKTIYVFSKENKRLFWFLYNSYVSECEFLLVFFHKQSCYLRSTSSGTFLERSHFYGKMEHIIIVCCNNFHKTLWPIKDPLIHYVRYQGKAILASRGTHLLMKKWRYYFVNFWQYYFHFWSQPYRMHINSLLNYSFYFMGYLLRVLINPYAVKNQMLENSFLIDTVIKKFDTIIPIIPLIGSLSKAKFCTFSGHPISKPIWADLSDFDIIDRFGRICRNLSHYYSGSSKKQSLYRIKYILRLSCARTLARKHKSTARALLQRLGLGFLEEFFTEEEQVLSFIFPKTTLFTLHGSHRERIWSLDIIRINDLVNN
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HGD_PSEU2
Sequence: MAIHSSSDALVYQSGFGNQFSSEALPDALPVGQNSPQKHPLGLYAEQFSGTAFTVARSEARRTWLYRIKPSAAHSRYQRMDRQMAGQEPGPINPNRLRWNAFDIPAAPTDFIDGLIPLASTSAAEQAEGVSVYLYTANTSMQRAFFSADGEWLVVPQQGRLRIVTELGLLDIEPLEIAVLPRGLKFCVQLLDSSARGYLCENHGCALRLPELGPIGSNGLANSRDFLTPVAWFEDSRQPMQLVQKFLGELWSTQLEHSPFDVVGWHGNNVPYKYDLRRFNTIGTVSYDHPDPSIFTVLTSPGAIHGQANIDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLIDGAYDAKAEGFMPGGASLHNCMSAHGPDNVTAEKAIAAELKPHRIDNTMAFMFETGKVLRPSRHALDCPQLQTDYDACWKDMARTFTQEPR
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: TYSY_MYCTU
Sequence: MSIVTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase ThyA, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P4K2A_XENLA
Sequence: MDETSPLVSPDRDQTEYSYQSQCSPGATVPLSPNGRFSALPGVVVRIPGTATSCGSAASGPSPPGSPCDQERQPLLERSQTRAAAAQAEREMNKFPDDPAFAEVVKKAEKAIMRDILPERISQGSSGSYFVKDEQGEIIAVFKPKNEEPYGQLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLDLNIVPRTKVVFLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQIFVKSYKDADYWLRRFEADPLPENTNRQLQLQFERLVVLDYIIRNTDRGNDNWLIKYDCPMDSASARDDWVMVKEPVIKIAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKIQFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDQGFDRGQFRKQIAVMRGQILNLTQAMKDGKSPLQLVQTPPVIVETARSHQKSTSESYTQSFQSRKPFFSWW
What is the function of this protein?
Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking.  Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
What are the official names of this protein?
Phosphatidylinositol 4-kinase type 2-alpha, Phosphatidylinositol 4-kinase type II-alpha.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Membrane raft. Endosome. Cytoplasmic vesicle. Cell projection, dendrite. Presynaptic cell membrane. Synapse, synaptosome. Mitochondrion. Membrane. Cell membrane. Perikaryon. Cell projection, neuron projection.
Protein: LIPB_PASMU
Sequence: MSNLSPLLVRQLGIQDYQTVWQQMQTFTDSRDVDTQDEIWLVQHPAVFTQGQAGKAEHLLQQTTIPVVQSDRGGQITYHGLGQQVMYVLVDIKRQKALGNEFNVRQLVSALEQAVVNTLADYGIHAYPKADAPGVYIDEKKICSLGLRIRKGCSFHGLALNINMDLSPFHFINPCGYAGLEMCQLADFIDPQQASCEKVAPKLVAHFAQLLGYNATNF
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.