Protein: KMT2A_MOUSE
Sequence: MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPQAGGGGPGAPPSPPAVAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKASPRKPRGRPRSGSDRNPAILSDPSVFSPLNKSETKSADKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDIAELTQGSKEDSLKKVKRTPSAMFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRIIPSCKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPMKIARLESTPNSRFSATSCGSSEKSSAASQHSSQMSSDSSRSSSPSIDTTSDSQASEEIQALPEERSNTPEVHTPLPISQSPENESNDRRSRRYSMSERSFGSRATKKLPTLQSAPQQQTSSSPPPPLLTPPPPLQPASGISDHTPWLMPPTIPLASPFLPASAAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDIHKRSPILRAPRFTPSEAHSRIFESVTLPSNRTSSGASSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSTSELSPLTPPSSVSSSLSIPVSPLAASALNPTFTFPSHSLTQSGESTEKNQRARKQTSALAEPFSSNSPALFPWFTPGSQTEKGRKKDTAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSDIQSSSALYPVGRVSKEKVAGEDVGTSSSAKKATGRKKSSSLDSGADVAPVTLGDTTAVKAKILIKKGRGNLEKNNLDLGPAAPSLEKERTPCLSAPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSVAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGICTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKASLQKQTKAVKKKEKKSKTTEKKESKESTAVKSPLEPAQKAAPPPREEPAPKKSSSEPPPRKPVEEKSEEGGAPAPAPAPEPKQVSAPASRKSSKQVSQPAAVVPPQPPSTAPQKKEAPKAVPSEPKKKQPPPPEPGPEQSKQKKVAPRPSIPVKQKPKDKEKPPPVSKQENAGTLNILNPLSNGISSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCESLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQASLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDEQQPLDLEGVKKRMDQGSYVSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSNNSGMLPNAVLPPSLDHNYAQWQEREESSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIDDNRQCALCLMYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIMECRPPVVEPDINSTVEHDDNRTIAHSPSSFIDASCKDSQSTAAILSPPSPDRPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPLRSKLRIMSPVRTGSAYSRSSVSSVPSLGTATDPEASAKASDRGGLLSSSANLGHSAPPSSSSQRTVGGSKTSHLDGSSPSEVKRCSASDLVPKGSLVKGEKNRTSSSKSTDGSAHSTAYPGIPKLTPQVHNATPGELNISKIGSFAEPSTVPFSSKDTVSYPQLHLRGQRSDRDQHMDPSQSVKPSPNEDGEIKTLKLPGMGHRPSILHEHIGSSSRDRRQKGKKSSKETCKEKHSSKSYLEPGQVTTGEEGNLKPEFADEVLTPGFLGQRPCNNVSSEKIGDKVLPLSGVPKGQSTQVEGSSKELQAPRKCSVKVTPLKMEGENQSKNTQKESGPGSPAHIESVCPAEPVSASRSPGAGPGVQPSPNNTLSQDPQSNNYQNLPEQDRNLMIPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSNSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATSRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVIKSAVGHKNEPKLDNCHSVSRVKAQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNAELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLTLGEGLGLDSNREKDIGLFEVFSQQLPATEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSEGDPALLSPGVDPAPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNSQDLTRNSGTPGLQVPVSPTVPVQNQKYVPSSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSPVSSTPSVMETNTSVLGPMGSGLTLTTGLNPSLPPSPSLFPPASKGLLSVPHHQHLHSFPAAAQSSFPPNISSPPSGLLIGVQPPPDPQLLGSEANQRTDLTTTVATPSSGLKKRPISRLHTRKNKKLAPSSAPSNIAPSDVVSNMTLINFTPSQLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIMYFEQAPLLPPQSVGGTAATAAGSSTISQDTSHLTSGPVSALASGSSVLNVVSMQTTAAPTSSTSVPGHVTLANQRLLGTPDIGSISHLLIKASHQSLGIQDQPVALPPSSGMFPQLGTSQTPSAAAMTAASSICVLPSSQTAGMTAASPPGEAEEHYKLQRGNQLLAGKTGTLTSQRDRDPDSAPGTQPSNFTQTAEAPNGVRLEQNKTLPSAKPASSASPGSSPSSGQQSGSSSVPGPTKPKPKAKRIQLPLDKGSGKKHKVSHLRTSSEAHIPHRDTDPAPQPSVTRTPRANREQQDAAGVEQPSQKECGQPAGPVAALPEVQATQNPANEQENAEPKAMEEEESGFSSPLMLWLQQEQKRKESITERKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRQSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN
What is the function of this protein?
Histone methyltransferase that plays an essential role in early development and hematopoiesis (By similarity).  Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (By similarity).  Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism.  Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity).  Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (By similarity).  Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (By similarity).  Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (By similarity).  Required for transcriptional activation of HOXA9 (By similarity).  Promotes PPP1R15A-induced apoptosis (By similarity).  Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (PubMed:21113167).  Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (PubMed:21113167).  Also has auto-methylation activity on Cys-3879 in absence of histone H3 substrate (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase 2A, Lysine N-methyltransferase 2A, ALL-1, Cysteine methyltransferase KMT2A, Myeloid/lymphoid or mixed-lineage leukemia, Myeloid/lymphoid or mixed-lineage leukemia protein 1, Zinc finger protein HRX.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [MLL cleavage product N320]: Nucleus. SUBCELLULAR LOCATION: [MLL cleavage product C180]: Nucleus. Note=Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320.