PharMolix/UniProtQA huggingface dataset:
Protein: GBG_NEUCR
Sequence: MPQYASRDVGDPSQIKKNKQSMADLKLRRLTELNNRLREDLERERIPVSQAAKSIITYCNSTRDYMVPSVWGPVPKSEDPYLPQQSSGCCVVM
What are the official names of this protein?
Guanine nucleotide-binding protein subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the G protein gamma family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: DNAE2_PSEA7
Sequence: MSAYAELHCLSNFSFQRGASSAAELFARAARLGYRALAITDECSLAGIVRAWQAAREYRVKLLVGSEIRLEQGPKLVLLAEDLAGYQQLCRLITRGRRRADKGSYRLLREDLQPALDGVLAIWLAEPGDDDDAAWLGECFPQRLWLGVELHRGADDDARLRGLLALAARAQLPAVACGDVHMHCRGRRALQDCMTAIRNHLPVSEAGAHLFANGERHLRPLAALQGIYPEALLAETLRIAERCRFDLEQLKYQYPRELVPAGHDPASWLRRLTEKGIRRRWPDGASAKVREQIEKELKLISELGYESYFLTVQDIVGFARRQKILCQGRGSAANSAVCFALGITELDPERINLLFERFLSRERNEPPDIDVDFEHERREEVIQYVFNRYGRQRAALTAVVSTYHGAGAVRDVAKALGLPPDQVDALANCCGRWSDRAPSAERLMEAGFDPQSAVLRRVLALTGELVGFPRHLSQHPGGFVISEQPLDTLVPVENASMVERTVIQWDKDDLDAVGLLKVDVLALGMLSALRRSFDLLHELRGGERLSLASIPSEDPATYAMISRADTIGVFQIESRAQMAMLPRLRPEKFYDLVIQVAIVRPGPIQGDMVHPYLRRRNGEEPVAYPSVELEKVFERTLGVPLFQEQVMELAIVAADYSPGEADELRRSMAAWKRHGGLEHHRERLTRGMLANGYEADFAARIFEQIKGFGSYGFPESHAASFALLTYASSWLKRHEPAAFACALINSWPMGFYSPDQLLQDARRHAIQTRPVDVRHSRWDCSLEPIGQEQPAIRLGLRMIRGFREEDARRIEQARQAQSFTDVHDLGRRAGLDTRALELLADAGALRGLAGHRHKARWAIAGVEPQLPLFAEGPRIEEPAISLPLPSRGEELLSDYALLGTTLGPHPLKLLRVQLKARRCRASRELVGMEHGRPVRIAGLVVGRQRPQTASGVTFITLEDEFGMVNVVVWHDLAERQRRPFLESRLLQVEGTLESSSGVRHVIAGRLQDLTPLLTGLDVRSRDFH
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAMT_BOVIN
Sequence: MSAPAATPIFAPGENCSPAWRAAPAAYDASDTHLQILGKPVMERWETPYMHALAAAAASRGGRVLEVGFGMAIAATKVQEAPIEEHWIIECNEGVFQRLQDWALQQPHKVVPLKGLWEEVAPTLPDSHFDGILYDTYPLSEETWHTHQFNFIRDHAFRLLKPGGVLTYCNLTSWGELMKTKYSDITTMFEETQVPALLEAGFRRDNIRTQVMELVPPANCRYYAFPRMITPLVTKH
What is the function of this protein?
Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.  Important in nervous system development.
What are the official names of this protein?
Guanidinoacetate N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
Protein: IRF7_HUMAN
Sequence: MALAPERAAPRVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEADARIFKAWAVARGRWPPSSRGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSGDPADPHKVYALSRELCWREGPGTDQTEAEAPAAVPPPQGGPPGPFLAHTHAGLQAPGPLPAPAGDKGDLLLQAVQQSCLADHLLTASWGADPVPTKAPGEGQEGLPLTGACAGGPGLPAGELYGWAVETTPSPGPQPAALTTGEAAAPESPHQAEPYLSPSPSACTAVQEPSPGALDVTIMYKGRTVLQKVVGHPSCTFLYGPPDPAVRATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGPQLWARRMGKCKVYWEVGGPPGSASPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQRRGSPRYTIYLGFGQDLSAGRPKEKSLVLVKLEPWLCRVHLEGTQREGVSSLDSSSLSLCLSSANSLYDDIECFLMELEQPA
What is the function of this protein?
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:28342865).  Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995).  Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway.  Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity).  Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase.  Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases.  This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes.  Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1.  Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency.  Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045).
What are the official names of this protein?
Interferon regulatory factor 7, IRF-7.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
Protein: ALR_TREDE
Sequence: MRATKAIIHLDNLQYNIKEIKKRLNKNVKICLPVKADAYGHGAVRVAVAAIRAGVSYLAVASIQEAVELREAGIVAPIISLSLPVLEEIPELLKYDIEPLVIDEEFINDLNRFAKKLNKKAWVHLKIDTGMRRIGCSPMEAVKLAVQIDRAENLELKGVCTHFAVSDSTDEKNIKFTKKQISVFKDSIKEIKKAGINPGLIHAANSGSVLQYPEAQFDMVRPGILVYGYAPSPSLNSLIDLKPVMELVTQVVLIKKIEKDTSVSYDRCWTAEKETFVATLPIGYADGLMRSLSGLKVRIGKDFFPIIGRICMDQCMIDIGASPWVQRWDEVCIFGPVSKEHPKNNTAQDLAKIAGTIPYELTCDINKRVPRIFIDETIQ
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: TPS3_DICPU
Sequence: MQKEIYYTFDINNIKDKEFTKVFVDCPWEAIRNPTPIDESEHLQWLKDSNLFDCDQDAENFFKDKTYIMSSYINPLNPKDNIIWVIRMHDFIYIVDDFYFEKGLLGEEWVINMFDRDAPQDKIGKTFWNIIEGMEKTGNKKAVEQLLHDTKIWALSVFTYNKCNINSESSFEYYCKYRCLDVGMDFGLSTAKVFAEPLPKEVLESSTYKRIIFGYNQTHSLINDMVSFERERKESNRMANYVMVHAYKTNSVQESMYHCKQMVEGVFNEINVLCEQLKREFPDVSNLDFHLNLIKLVISGDNYVSNDTTYPRYNLNH
What is the function of this protein?
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene CAS 137235-51-9 as a major product (PubMed:30254228).  Is also able to convert FPP into 9-epi-(E)-caryophyllene, alpha-neoclovene, beta-neoclovene, and 3 yet unidentified sesquiterpenes (PubMed:30254228).
What are the official names of this protein?
Terpene synthase 3.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: G6PI_OENSH
Sequence: MASPALISETEAWKDLKAHVEDIKRTHLRELMGDTERCQSMMVEFDNIFLDYSRQQASPDTINKLYKLADAAHLKQKIDRMYNGDHINSTENRSVLHVALRAPRNSAICSDGKNVVPDVWNVLDKIKDFSERVRNGSWVGATGKELKDVIAVGIGGSFLGPLFVHTALQTDPEASKNARGRELRFLANVDPIDAARNISGLDPETTLVVVVSKTFTTAETMLNARTLREWISSALGPSAVAKHMVAVSTNLPLVEKFGIDPNNAFAFWDWVGGRYSVCSAVGVLPLSLQYGFAVVEKFLQGAHNIDQHFSSAPFEKNIPVLLGLLSVWNVSFLGYPARAILPYSQALEKLAPHIQQVSMESNGKGVSIDGLPLPFESGEIDFGEPGTNGQHSFYQLIHQGRVIPCDFIGVVKSQQPVYLKGEVVNNHDELMSNFFAQPDALAYGKTPEQLKKENVSEHLIPHKTFTGNRPSVSILLPTLDAYRIGQLLAIYEHRVAVQGFIWGINSFDQWGVELGKSLATQVRKQLHASRVKGESVEGFNFSTKTLLTRYLEATSDVPAAPSTLLPKI
What are the official names of this protein?
Glucose-6-phosphate isomerase, cytosolic, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_BACAA
Sequence: MSSVPASAYLTLAIILFCIGLFGALTKRNTVIVLVCIELMLNAANLNFVAFSKLGLFPNLTGQIFSLFTMAVAAAEAAVGLAILIALYRNRTTVHVDEMDTLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2442_MYCLE
Sequence: MSTAWDTVWHACSVIEHALQASHLTYSEFSGVPDGLLRLVVELPGERRLKTNAILSIGEHSVHVEAFVCRKPDENHEGVYRFLLKRNRRLFCVSYTLDNVGDIYLVGRMSLASVDTDEIDRVLGQVLEAVESDFNTLLELGFRSSIQKEWDWRISRGESLNNLQAFAHLIDDEGDGDASIYARP
What are the official names of this protein?
Uncharacterized protein ML2442.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv0487.
Protein: MRAY_BURPS
Sequence: MLLALAQWLQGDASFLRLFTYLTFRAVMATITALVIGLVCGPWVIRKLTQMKVGQAVRKDGPQTHLVKSGTPTMGGVLILIGIAVATLLWGDLTNRFIWIVMLVTFGFGVIGWVDDYRKVVYKDPRGMSSREKYFWQSVIGLFAAVYLAFSVSEANNVRVFDLFMAWVRSGLSMGLPARADLMLPFLKSISYPLGVWGFIALTYFVIVGASNAVNLTDGLDGLVIMPVVLVGASLGVFAYVMGSAVYSKYLLFPHIPGAGELLIFCSAMGGAGLAFLWYNTHPAQVFMGDVGALALGGALGTVAVIVRQEIVLFIMGGIFVAETLSVMLQVTWFKYTKKRYGEGRRIFKMAPLHHHFELSGWKETQVVVRFWIITLMLCLFGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF2_RHOP2
Sequence: MVDTKTPGDKTLSMPSKTLTLKPRVEQGVVRQSFSHGRSKQVVVEKRGKRRIGGDGAPEPAAAPEVAKKPAPAPAPAAPSPRQQPRPSPQQQARSGMVLRTLTEDERSARATALADARVREVEERRQAEIEAQRRAAQEVVDKAEREAAEARRKAEEERHRHEEETKRKAETEAKKRFGETEPAARKPADGGRPAAGATTTAPRAPVTTTTTRPPAVAAEAGDDDEAPRMVRRGPGGGPARPAPPPKQPAAKPGASKQRGRLTLVTALNADDVRERSIASFRRRTQRLKGHASNEPKEKLVREVIVPEAISIQELANRMSERAVDVIRLLMKQGAMHKINDVIDADTAQLIAEELGHTVKRVAASDVEEGLFDVVDNSTDTEPRSPVVTVMGHVDHGKTSLLDALRHANVVSGEAGGITQHIGAYQVTSPESGKKITFIDTPGHAAFTAMRARGAKVTDIVVLVVAADDGVMPQTIEAINHAKAANVPIIVAINKIDKPDAKPERVRTELLQYNVQVESLGGDVVDVEVSAKNKTNLDKLLEMIALQAELLDLKTNEQRPAEGTVIEAKLDRGRGPVATVLVQRGTLKVGDIIVAGAEMGRVRALISDQGDTVDSAGPSVPVEVLGFNGPPEAGDRLAVVENEARARQVTSYRAHQKREKAASIVGMRGSLEQMMSQLKTTGRKDFPLIVKADVQGSLEAILGSLEKLGTDEVAARILHAGVGGISESDVTLAEGFSAVILGFSVRANKEAAAAAKRNGIEIRYYNIIYDLVDDIKKAMSGLLAPTLRETMLGNAQILEIFNISKVGKVAGCRVTDGTVERGANVRLIRDNVVVHEGKLSTLKRFKDEVKEVQSGQECGMAFENYTDMRAGDVIECYRVETIQRSL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURT_XANC5
Sequence: MTTFGTPLSPSATRVLLLGSGELGKEVAIELQRFGVEVIAADRYANAPAMQVAHRSHVLDMLDPAALRALIASEQPHLIVPEIEAIHTETLVALEREQGQKVIPTARAARLTMDREGIRRLAAETLCLPTSPYRFVDTVEEYRNAIAAVGVPCVVKPVMSSSGKGQSTLRSEADIDAAWAYAQTGGRAGAGRCIVEGFIDFDYEITLLTVRHAGGTSYCDPIGHWQQDGDYRESWQPQPMSAAALRRSQEIAKAITDELGGWGLFGVELFVKGDEVWFSEVSPRPHDTGLVTLVSQDLSEFALHARAILGLPVGAQDGGVIRQAGPSASCALLAHGNGVPVFDNVAEALRDPDTALRLFGKPRVDGHRRVGVTLARADSIDAAREKARVAAAALTIQLQA
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: GSA_METM7
Sequence: MELNIKMDRSRELFEESRKYLVGGVNSPVRSFKPFPFFVKSAKDCFLYDEDGNEFIDYCLAYGPMVLGHANENILNAVKSQMDLGTAYGVPSEKEIILAKEVINRIPCAEMVRFVNSGTEATMGAIRLARGVTKRNKIIKFEGAFHGAHDYVLVKTGSGALTHGAPNSPGIPEDTTKNTLLIPFNDEDAVKKVISENKDEIACIILEPVMGNVGCILPKDGYLQFLREITEENGIILIFDEVITGFRLSKGGAQEYYGIKSDLATVGKILGGGFPIGAITGKKEYMEQFSPNGQIYQAGTFNGNPVSVTAGIETLKNLDDKFYKETTKKADILSSFLRETAEKYNVPAKVYNVASIFQIYFNDKEIVTYEDAKSSDTEKFMRYFYTLLENGVFIAPSQFECCFTSIKHNDEVLEKTMNAIDIAMKKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_STRPD
Sequence: MNLLIIGLPGAGKGTQAAKIVEEFGVAHISTGDMFRAAMANQTEMGRLAKSYIDKGELVPDEVTNGIVKERLAEDDIAEKGFLLDGYPRTIEQAHALDATLEELGLRLDGVINIKVDPSCLVERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNMAQGEPILEHYRKLGLVTDIEGNQEITDVFADVEKALLELK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_SALTO
Sequence: MYAIVKTGGKQYKVAEGDVIEVEKLAGTPGDAVQLAAVLLVDGDDLVTDAAKLAKVEVSGEIAAHTKGPKIRIHKFKNKTGYHKRQGHRQPLTQVKVTGISSGK
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: HMGYB_SOYBN
Sequence: ALNEADGSNKSAISKYIETTYGELPDETVLGSHLNKMKESGELAFKQNNYMKADPNAPPKRGRGRPPKPKVPLPPGTVVSPPRPRGRPPKDPNAPPKSPKAKATPATGRPRGRPKKVARSPAVPSPTAVSTGRPRGRPPKVKPQLTEVSVES
What are the official names of this protein?
HMG-Y-related protein B, Protein SB16B.
What is the protein family that this protein belongs to?
Belongs to the HMGA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLME_BAUCH
Sequence: MCAKKRSASSNRWLQESLKDKYVVQAQKKGLRSRAWFKLDQIQKSDRLFQPYMTIIDLGAAPGSWSQYVTTQIGKNGHVIACDLRYMSPLSGVDFIQGDFCNKQVLQAILQRLENKKAQVILSDMSPNFSGKPEIDIPKSMYLVEKALKMCRYLLIPGGTFIVKVFQGDGFYEYICSMHALFNTVKIIKPDASRSRSREVYLIAKGHKI
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROGDI_DROME
Sequence: MKMLADTEREEALNLQIEFEWVLRQEVHAILKQLRSILVECAHRFPVPLYENEGKKTEKFILTVSPDQLKAVLTLTGDAITQADISFKLCKAPSQTQRTSITHDSPWKLQQVQDAANHLQTAINHIDDVDDSYHFKTSDEVLHVIGNILDALQRGRNSLLVPKKKPIDELIKGRNMKSLVPNLPEDLAVSFYLQSHKLIIAVYQLLNNQGTMRFDSRQAEASVQWLNDVLLLLMNGQKLCQQLKDKISVFSVYKDFTVGSRSPSALSY
What is the function of this protein?
Plays a role in promoting sleep by enhancing metabotropic transmission of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in GABAergic neurons upstream of a wake-inducing dopaminergic pathway.
What are the official names of this protein?
Protein rogdi.
What is the protein family that this protein belongs to?
Belongs to the rogdi family.
What are the subcellular locations of this protein?
Nucleus envelope. Presynapse. Cell projection, axon. Perikaryon. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Detected primarily at presynaptic sites on axons, and to a lesser degree in soma and dendrites. Not detected at post-synaptic sites.
Protein: AROC_FRATN
Sequence: MSGNTFGKIFTVTTCGESHGDSLAAIIDGCPSNIPLCEADIQLELDRRKPGQSKFTTQRKEPDEVKIISGVFEGKTTGTPIGLIIKNQDQKSKDYSEIKDKFRPGHADYTYFKKYGIRDYRGGGRSSARETAMRVAAGAIAKKILKHYGIEIYGFCSQIGSLKIDFIDKDFINQNPFFIANKNAVPACEDLIHSIRKQGDSIGAEVTVVATGLEAGLGRPVFDRLDASIAYAMMSINAVKAVSIGDGFDCVAQKGSQHRDEITQQQGFLSNHAGGILGGISTGQDIIAKLAFKPTSSILQPGKSIDVQGNDTTVITKGRHDPCVGIRGVPIAEAMLALVLVDELLITRSYRD
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: EFTS_ECOL6
Sequence: MAEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAKKAGNVAADGVIKTKIDGNYGIILEVNCQTDFVAKDAGFQAFADKVLDAAVAGKITDVEVLKAQFEEERVALVAKIGENINIRRVAALEGDVLGSYQHGARIGVLVAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDIAMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKTVGQLLKEHNAEVTGFIRFEVGEGIEKVETDFAAEVAAMSKQS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEY1_PYRTR
Sequence: MMNAHFAGVGDNADNAAYEHGIQVIDEDKMFNGNVSTYLNIEKVIPAGFNYHLISVFGSQSTGKSTLLNHLFGTQFGVMSEQERRQTTKGIWMSKNKRESGGSSMAENILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLQLFVKDSQSTPRSLLFFVIRDHLGTTPLKNLQNTLVQDLSKLWSTISKPAGLENSRIEDYFDFAFVALPHKILQPEKFDEAVTQLSTRFKEGYNDPRKSGLIDEATAPIFLPQYHRRIPADGFSAYAEGVWDQIVNNKDLDLPTQQELLAQFRCDEISREVQVAFDETITPLEDKQAEDARAGTHSLIPDLGPKMNAARQKVLKDFDVNASRYHKGVYKRKQAELEGKVDTRLKALFQKQLTAAHKSGIEGFTEAVSAAVKNGQKKNASYDFAQIVDSEKKKALTKFEEDATAMAIEGAAWSSHENELKIYKKELDDVSGRLRKEEMRRLATRIERWVRTRLDESIGLEFNKLGSGRGGSGAPEHGDRPPTEKDLWDRVWTIFTDTVKMAEKRFTDRASSFDASADEVEVGLWRLRRKSWGVLRAKIDEEVMEGNILLKLRENFEDKFRYDDLGVPRIWRPTDDIDGLYTKARESTITVIPLLAHFKLAKTSKPPPLDAWIGEAPASVSPADEEDLSPIGGVDDDEDKTLEDEMTILSDGKQADLLVRFKKTADGVYVEAKRGAIGGLSQIPFWLYPAMLALGWNEIVAVLRNPIYFIFLILLAVAAYVTYTLNLWGPIMRVANAASQQGLEVGKERLRAFLENSDAGRQAMAMSGSGDSNSTRRYEDVKMDRLNGDGKKSKSMEEDLDDI
What is the function of this protein?
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein sey1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: IF2_ECOBW
Sequence: MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARAAVRGGKGGKRKGSSLQQGFQKPAQAVNRDVVIGETITVGELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAQVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFVHVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITETDATLAAASNAILVGFNVRADASARKVIEAESLDLRYYSVIYNLIDEVKAAMSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVVKRHNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIQRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TVBX1_HUMAN
Sequence: MASLLFFCGAFYLLGTGSMDADVTQTPRNRITKTGKRIMLECSQTKGHDRMYWYRQDPGLGLQLIYYSFDVKDINKGEISDGYSVSRQAQAKFSLSLESAIPNQTALYFCATSDL
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 24-1.
What are the subcellular locations of this protein?
Cell membrane.