PharMolix/UniProtQA huggingface dataset:
Protein: DDAH_PSEAE
Sequence: MFKHIIARTPARSLVDGLTSSHLGKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFYPGKVERIEAPGTVEAGDIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVRLEKVLHLKTGLAYLEHNNLLAAGEFVSKPEFQDFNIIEIPEEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF
What is the function of this protein?
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA).
What are the official names of this protein?
N(G),N(G)-dimethylarginine dimethylaminohydrolase, DDAH, Dimethylarginine dimethylaminohydrolase, Dimethylargininase.
What is the protein family that this protein belongs to?
Belongs to the DDAH family.
Protein: Y1579_PSEAE
Sequence: MRGILRMTVLAAAVFGVAGNALAEDWKLAKDEDGVKVYLSSVQGSKYKAYRGVTDIKADVATIEALQEDVKGSCKWIHACAEMKLLKQEGADAWTYSKIDMPWPVTGRDVVIHVTTEKTADGTVIRHLKADPTYIPEEKGQIRVPKLVGEWKLQPKGQGVTEVTYQVETEPGGSIPSWLANSFVVDAPLNTLKGLRSAAEKR
What is the function of this protein?
May play a role in the interaction of the bacterium with animal cells.
What are the official names of this protein?
Uncharacterized protein PA1579.
Protein: RK5_NEPOL
Sequence: MAQRLKTFYLNSVVPKLRQQFHHRNIHEVPSIKKIVINRGLGDASQNAKLLDGSLQELTTIAGQRGVITRSKQAIAAFKIRQDMPVGISVTLRGERMYAFLDRLINLALPRIRDFQGMSTKSFDGQGNYSLGLNEQLMFPEINYDAIDQMRGMDISIITSATEDREGFALLQALGMPFRTATID
What is the function of this protein?
Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L5, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: R1B8_SOLDE
Sequence: MIEFWRSEYTRILSICPDPGKKYRNKNVRMWSLYLERVREVIWKTKQEFKAEYSFPKTSLAANKVDDVSPKFVMEVMDVFVENLNVLMKINDPCLWLFVPGHMKEQIEQVLKELKLLRFFVCFVSSKCIEPQYRRTTFYTHALIEASHNAMVVWLHLPVYGNKNQDLAPTEVSRLLSDFMEMKIKSIQPGNSIYIDVLQALKSTIPQAQQKHAAESGIVEIPIHSLTVGLSDQMANLQEMICLLRDNLIHLPILDLEFHLQDMDSVILDAGLLIYSFYDIKGEKEDTMLEDINRALGFDLPRNIEPIKAMVYLVMQKAFQCNLPRVHGLGYVDFLLKNLKDFQGRYSDSLAFLKNQLQVIQTEFESLQPFLKVVAEEPHNKLKTLNEDCATQIIRKSYEDIIEEITCIKAKIQEKNTVEDTMKTVIARTSSQLARTLRMNEEIVGFEDVIEKLRNRLLNRTKGQDVISIHGMPGLGKTTLANRLYSDMSVVSQFDICARCCVSQVYSYKDLLLSLIRDAIGENSDQHRELIRDAIGENSDQHRELCANELADKLRKTLLRRRYLILVDDVWENSVWDDLRGWFPDANNRSRIILMTRHHEVAKYASVHGDPLHLRMLDEDESWKLLEKKVFGEQSCSSPLLKNVGLRIAKMCGQLPLSIVLVAGILSEMEKEVECWEQVANNLGSHIHNDSRAIVDQSYHVLPCHLKSCFLYFGAFLEDRVIDISRLIGLWISESFIKSCEGRRLEYIAEGYLENLIGRNLVMVTQRAISDGKVKACRLHDVLLDFCKKRAAEENFLLWINRDQSTKAVYSHKQHAHLAFTEMDNLVEWSASCSLVGSVLFKSYDPYFRPLSSHAFAISHILLNFKFLKVLDLEHQVIIDFIPTELFYLRYLSAHIDQNSIPSSISNLWNLETLILKSRSASKHNRVLLPSTVWDMVKLRHLHIPYFSTEDEEALLENSAKLYDLETLSSPYFSRVEDAELMLRRTPNLRKLICEVQCLESPHQYHVLNFPIRLEILKLYNRSKAFKTIPFCISAPNLKYLKLSRFYLDSQYLSETADHLKHLEVLKLSCVEFGDHGEWEVSNGMFPQLKILKLEYVSLMKWIVADDVFPNLEQLVLRGCRHLMEIPSCFMDILSLKYIKVDEYSESVVQSARKIQETQIEEYQNNNFKLVIIKVHYREKLNELFSLLSLTVLGLVLHPIFL
What is the function of this protein?
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1.  Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein.  That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
What are the official names of this protein?
Putative late blight resistance protein homolog R1B-8.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: FMT_MYCA1
Sequence: MPVRLVFAGTPEPALPALRRLLDSPRHEVIAVLTRPDAASGRRGKPEPSPVAREALDRGIPVLRPARPNSPEFVAELAQLAPDCCAVVAYGALLRDELLAVPPHGWINLHFSLLPAWRGAAPVQAAIAAGDTITGATTFRIEPALDSGPIYGVVTEAIRPTDTAGELLARLAVSGAELLSATLDGIADSTLTPRPQPAEGVSIAPKITVEQARVRWDLPAPVVERRIRAVTPNPGAWTVIGDLRIKLGPVRLGAASDLPAPPEPLPPGAIHVDRKSVWVGTASDPVRLDQIQPPGKKFMNAVDWARGARLDPAARAT
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: MIA40_DEBHA
Sequence: MYRLATRRVLAQTTQTFSKRTFSNQGFRAAKASKTNMYLGAGIALIPVIMSINYLNGNHIANEVDENKVEEGKKKAESTGKKEFVEKAEKEAIGKADVKTKVPAEEANPETRTETDKPSEESQKDEENSYEGAAYNPETGEINWDCPCLGGMAHGPCGEEFKEAFACFIYSESEPKGIECIKKFESMRNCFREHPEHYKEELYDDEEQEPLVDVNEKKGDASEQSAETIADDATKVVKEKAKAEDSNTK
What is the function of this protein?
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS).  Forms a redox cycle with ERV1 that involves a disulfide relay system.  Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.  The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
What are the official names of this protein?
Mitochondrial intermembrane space import and assembly protein 40, Mitochondrial import inner membrane translocase TIM40.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side.
Protein: RL23_LIMRD
Sequence: MEARDIILRPVVTEASMAGMDNKRYTFDVDLRATKTQVKNAVEEIFGVKVVKVNIMNVKGKLKRQGRYEGYTKRRRKAIVTLSADSNEIKLFNDNNEN
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: TREA_SALG2
Sequence: MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQNAKLFPDQKTFADAIPNSDPLMILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQSLREHIDGLWPVLTRSTKNVEKWDSLLPLPESYVVPGGRFREIYYWDSYFTMLGLAESGHWDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMVELLAQHEGDDALKEYLPQLQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATVKSNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASAAAGDRAKASHYDALANARQKAIEMHLWNNKEGWYADYDLKNNKIRDQLTAAALFPLYVNAAAKDRAAKVAAAAQAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVAMEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDSVPSTRPASLSATPTKTPSAATQ
What is the function of this protein?
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
What are the official names of this protein?
Periplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DTD_STRPN
Sequence: MKIIIQRVKKAQVSIEGQIQGKINQGLLLLVGVGPEDQEEDLDYAVRKLVNMRIFSDAEGKMNLSVKDIEGEILSISQFTLFADTKRGNRPAFTGAAKPDMASDFYDAFNQKLAQEVPVQTGIFGADMQVELVNNGPVTIILDTKKR
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPC29_KLULA
Sequence: MDVSQFLNNVENDDTLQNIRKEYLNSKRTLQELMTNQSPTKKMEFSKKPTLLQERNSNDYINRNVNSSKPTDDEFLRRQLREGLSRKPEPKISLPSLASDTNRLDSIYSSVNKIDELEKKLYHHELQIQALKNELYQSNASNRALQNKVAELQDSVRMLAALSHSNVKADTDNSQLSANGKWTRHYAGPNSNGNGVYLDRPQSAPSTSSTSEWVANALHDSDDTRVLLGWKQPSSTRVDNSSNFHFPHNQPRNLSNFDDNTSRLIGVTGKTRN
What is the function of this protein?
Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.  Links the central plaque component SPC42 to the inner plaque component SPC110 (By similarity).
What are the official names of this protein?
Spindle pole component 29.
What is the protein family that this protein belongs to?
Belongs to the SPC29 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: REV_SIVM2
Sequence: DSYPTGPGTANQRRQRRRRWRRRWQQLLALADRIYSF
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: Y274_STAHJ
Sequence: MNYKQSSPEVLRQLIRDGELVGHTSGMAEGYIQANVVILPSKYAYDFLKFCFRNPKTCPLLDVSEVGAHSFPYYGPYADIRTDVPKYRIYEHGQLIKEVDDITDLYTEDMVSFLIGCSFTFEHALLEAGLPVRHIEEGHNVPMYRTNIPAESSGYFKGNITVSMRPMTMTQAIKATEITSHFKNVHGTPIHIGTPEELGITDIDKPDYGEAVTIKPNEMPVFWGCGVTPQSVALDAKPELMITHSPGHMFITDIKDSELND
What are the official names of this protein?
Putative hydro-lyase SH0274.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: DNAA_TRIV2
Sequence: MEISIDSLWSQVLERLQIELSRPTFETWIKTANAERLENNCLVIITPNPFARNWLQKYYITTIANVVQSILGHPVEIYITVAKGEEFEEIGGGGAWELPTTNSIYETPNQNRQPNTELNAKYVFSRFVVGANNRMAHAASLAVAESPGREFNPLFLCGGVGLGKTHLMQAIGHYRWEICPDSKIFYVSTEQFTNDLITAIRNDSMQSFREHYRAADVLLVDDIQFIEGKEYTQEEFFHTFNTLHEAGKQVVIASDRPPNQIPSLQERLCSRFSMGLIADIQAPDLETRMAILQKKSEYEKIRLPRDVIEYIATNFTSNIRELEGALTRALAYISIWGLPMTVANLAPVLVTPTEKIAATPEAILTVIADNFDISVEDLKSNSRRREISWARQIGMYLMRQHTDLSFPRIGEEFGGKDHTTVLYSCDKIAQLVESDRGLSQTLRQLSDRIKMNSRSRKPSL
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_ACIAD
Sequence: MKQPVRVAVTGAAGQIGYSLLFRIASGEMLGKDQPVILQLLEIPVEKAQQALKGVMMELDDCAFPLLAGMIGTDDPKVAFKDADYALLVGSRPRGPGMERADLLKVNGEIFIGQGQALNEVASRDVKVLVVGNPANTNAYIAMKSAPDLPAKNFTAMLRLDHNRALTQIAQKAGVAVADIEKLTVWGNHSPTMYADYRFATANGENLKDKINDAEWNKDVFLPTVGKRGAAIIEARGLSSAASAANAAIDHMRDWALGTNGKWVTMGIPSDGSYGIPEGVIYGVPVTCENGEYKRVEGLEIDEFSRERMDKTLQELEEERAAIADMLK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: ARGJ_METAC
Sequence: MKKIEGGICAVKGVTANGIKLGKMGITVIRAEGPAAGVFTKNKVTAAPVVLSKGVIETQHQLSAIIANSGNANAFTGDDGFLDAMEMASALSESLDLEPDTVAVASTGVIGRRLDVSWIREHLPEVLEGLGSSPECSLAAAKAIMTTDKALKEVAVELDCGVRIGAIAKGSGMIEPNMGTMLCFAYTDALVPADVLDAALRIAVDKTFNMVVVDGDTSTNDMVLFTSTCKSGIKPCMECLDEFEDALIYLFTDLAKKMARDGEGATKLIEARVTGAKTYEDARLAVKAIVRSPLVKSAIFGKDPNWGRVVAAAGYSGAELEQERLSLSFSAGGETVELVKSGEISRVSDLALLNKIMANEEIIITLDFGMGKESATAWGCDLTYDYVRINAEYTT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUND1_MOUSE
Sequence: MATVEVATELGTVVTAVGPKAKDEEEEEEEEESLPPCETVRWAPVGAVAEAGPGAATFSEAAAAEEPGAAPGSPSDATVRTLRRLEAERRQLDSALLALSSHFAQVQFRLRQVVRGAPAEQQRLLRELEDFAFRGCPHVLGYEGLADPCGGDESDVLPGDRPRVRGEDQSEQEKRERLETQREKQKELILQLKTQLDDLETFAYQEGSYDSLPQSVVLERQRVIIDELIKKLDMNLNEDISSLSTEELRQRVDAAVAQIVNPVRVKEQLVEQLKTQIRDLEMFISFIQDEVGSPLQTGGHCECQASGKVGIGSTRVGGSTLPPGPGKAKAEDAKRARETGLHLMRRALAVLQIFTVSQLGCATGQIPQTLWQRSQADRDYSHLLKRLEVSVDRVKQLALRHQPHDHVITSANLQDLSLGGKDELTTVVRKELTVAVRDLLAHGLYASSSGMSLVMAPLACLLPVFSSAPETMHPWELFVKYYHAKNGRAYVESPARKLSQSFALPIMGDTAVTPKQSLLTAIHLVLTEHDPFKRSADSELKALVCMALNEQRLVSWVNLICKSGSLIEPHYQPWSYMAHTGFESALNLLSRLSSLKFSLPVDLAVRQLKNIKDAF
What is the function of this protein?
May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.
What are the official names of this protein?
RUN domain-containing protein 1.
Protein: SYS_PSEA8
Sequence: MLDPKLVRTQPQEVAARLATRGFQLDVARIEALEEQRKSVQTRTEQLQAERNARSKAIGQAKQRGEDIAPLLADVDRMGSELEEGKRQLDAIQGELDAMLLGIPNLPHESVPVGADEDANVEVRRWGTPKTFDFEVKDHVALGERHGWLDFETAAKLSGARFALMRGPIARLHRALAQFMINLHTAEHGYEEAYTPYLVQAPALQGTGQLPKFEEDLFKIGRDGEADLYLIPTAEVSLTNIVSGQILDAKQLPLKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVDPATSYEALEGLTANAERVLQLLELPYRVLALCTGDMGFGATKTYDLEVWVPSQDKYREISSCSNCGDFQARRMQARYRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSIRVPEVLKPYMAGIEVIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS182_MYCMM
Sequence: MKKKPRRTRRPIAAPATPAKKNLLDSLGVSEVDYKDISRLRTFISDRGKIRSRRVTGLTVQQQRQIATAIKNAREMALLPYPASRPQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: FOXA2_XENTR
Sequence: MLGAVKMEGHEATDWSSYYGEPEAYSSVGNMNAGLSMNPMNTYMSMSAMSTSANMTAGSMNMSYVNTGMSPSLTGMSPGTGAMTGMGTGVASMASHLSPSMSPMSAQATSMNALAPYTNMNSMSPIYGQSNINRSRDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKKPSLREGGGKKLSEGSSSVGSAANSSSESSVGNESPHSSSSPCQEQKRSLVDMKSSQGLSPDHAASPASQAQHLLSQHHSVLSHEAQSHLKPEHHYSFNHPFSINNLMSSEQQHHHHHHHNHHHHHKMDLKAYEQVMHYSGYGSPMTGSLAMSTVTNKSGLESSPISSDTSYYQGVYSRPIMNSS
What is the function of this protein?
Acts as a transcriptional activator during early development, limiting the extent of mesoderm formation in the gastrula.  Binds to DNA via the target sequence 5'-GT[AC]AACA-3', with 5'-GTAAACA-3' being the preferred binding site (By similarity).
What are the official names of this protein?
Forkhead box protein A2, FoxA2.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLOCK_DROME
Sequence: MDDESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLAYEMDHEALLNIFMNPTPVIEPRQTDISSSNQITFYTHLRRGGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITNNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQPSGSCQINPLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQSHHHMQQQQQHQNQQQQHQQHQQLQQQLQHTVGTPKMVPLLPIASTQIMAGNACQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQPVIAPFPVAPVLSPLPVQSQTDMLPDTVVMTPTQSQLQDQLQRKHDELQKLILQQQNELRIVSEQLLLSRYTYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQLQQQNDILLREDIDDIDAFLNLSPLHSLGSQSTINPFNSSSNNNNQSYNGGSNLNNGNQNNNNRSSNPPQNNNEDSLLSCMQMATESSPSINFHMGISDDGSETQSEDNKMMHTSGSNLVQQQQQQQQQQQILQQHQQQSNSFFSSNPFLNSQNQNQNQLPNDLEILPYQMSQEQSQNLFNSPHTAPGSSQ
What is the function of this protein?
Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours.  Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM).  According to PubMed:9742131, reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas PubMed:9616122 describes bimodal oscillating expression with maximum at ZT5 and ZT23.  Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters.  Once induced, Period and Timeless block Clock's ability to transactivate their promoters.
What are the official names of this protein?
Circadian locomoter output cycles protein kaput, dCLOCK, dPAS1.
What are the subcellular locations of this protein?
Nucleus.
Protein: IL6_CAMBA
Sequence: MNSLSTSAFSPVAFSLGLLLVMATAFPTPVPLGEDFKDGTTSNRPFTSPDKSEELIKYILGRISAMRKEMCEKYDKCENSKEALSENNLNLPKMTEKDGCFQSGFNQETCLMRITIGLLEFQIYLDYLQNYYEGDKGNTEAVQISTKALIQLLRQKVKQPEEVSTPNPITGSSLLNKLQTENQWMKNTKMILILRSLEDFLQFSLRAVRIM
What is the function of this protein?
Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability.  Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF.  Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity).  'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis.  Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity).  Also acts as a myokine (By similarity).  Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).  Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity).  Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
What are the official names of this protein?
Interleukin-6, IL-6.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: WDR5_MOUSE
Sequence: MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
What is the function of this protein?
Contributes to histone modification (By similarity).  May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity).  As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity).  H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity).  As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity).  May regulate osteoblasts differentiation (PubMed:11551928).  In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity).
What are the official names of this protein?
WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WD repeat-containing protein BIG-3.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR5/wds family.
Protein: SHE10_CANGA
Sequence: MRFLTKFLLFLATVYFGLKYACESPLRAQYPQLQLACHYSQPALWNDYLLKNSPAYKNSVHPQLVVAKGKYEELVQPHVKDVCKRVHTQLDRIDKKKYCDLAHSYANLAYQKAQFYYSISAGKYVHDFCKSDLYNKNLKRHVERAKEDLSKAYHLAVVRIPQLFTRENVEKFTSSASAYINEKTESLKKEAKQITSDVKKTVESEIKKRTTSSESEEEPIVSTSTIVKTITRTRHSSSSTTSTKSAEETSEKNLETKEEEDITDIEIDHQAQLQRDFDKWTSNIDKKVKMVNKMLVRDVKKHLKPKIDANDKLFKDKLKVLHKEANDNFQLINKAIQDINCTQGIDPETGKQIYFDSEGKSQIEKYITREMIRTMLNDTQTTLNSLVADIENDVSKILEDFKKIAENSREQHLTTFEEWGDIMINEWSKKLAYLDVLAPHEDAEHEGKSKTELSEKNWKKFMAIKKQILDARDKMAKRQIKISEFKLLLDNVQNTLQAVTNENGEYLYILRAQANLAFQERERLEKEAEEAKLRKEAGEVNESSEEEQIVEEPISA
What is the function of this protein?
Involved in spore wall assembly.  May be a component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria.
What are the official names of this protein?
Outer spore wall assembly protein SHE10, Sensitivity to high expression protein 10.
What is the protein family that this protein belongs to?
Belongs to the SHE10 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MPS2_YEAS8
Sequence: MSNGAFDAIFEYAWGQIDKPISGDFIYGKDLPKLIEIIENIFQKAQKSGSYELRLPLFSEINKDLFRTFSNTKTFFKIHKEEFDDIFFNLVNHPLREILENAFIGVDSIPSDFIVSMNLNSPSKFLVENKSKNTEGAGISTPRKKLTESPIKLLSRNNIGKALEVQVEELKRELTAKQSLLQENERQVSELKIRLETYQEKYASIQQRFSDLQKARQVEDNQNSSRTSDPGSPLVTGIDQKAILEEFRRRLQRQTDTISFLKDQIRRERGLNCSNDKVSHSKRKHATTDGDGTFKNFISAVPSNIWVKATIRIIVCFALLAGVLPYIRKYVYAHDTPSQNSRLQLSWWENSGILSKIVWFFEDQTDLETEYRSNANVDDAYSRVFGI
What is the function of this protein?
Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.
What are the official names of this protein?
Monopolar spindle protein 2.
What is the protein family that this protein belongs to?
Belongs to the MPS2 family.
What are the subcellular locations of this protein?
Nucleus membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: MATRX_ABLVB
Sequence: MRKTVNTTDKMNFLRKIVRNCKDEDDQKPPLASTLPNDDDLWLPPPEYVPLTEITGKKNMRNLCINGEVKVCSPNGYSFRILRHILESLDEIYSGNHRMIGLVKVVMDLTLSGAPCPEGMNWVYKLRRTLIFQWAESRGPLDGEELEYSQEITWDDDSEFVGLQIRVSARQCHIQGRIWCINMNSRACQLWSDMSLKTQQSEDHKNSSLLLE
What is the function of this protein?
Plays a major role in assembly and budding of virion.  Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form.  Inhibits viral transcription and stimulates replication.  Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity).
What are the official names of this protein?
Matrix protein, Phosphoprotein M2.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein.