PharMolix/UniProtQA huggingface dataset:
Protein: SYTL2_HUMAN
Sequence: MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK
What is the function of this protein?
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes.  It is required for cytotoxic granule docking at the immunologic synapse.  Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells.  Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
What are the official names of this protein?
Synaptotagmin-like protein 2, Breast cancer-associated antigen SGA-72M, Exophilin-4.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery.
Protein: ENGB_ECOSM
Sequence: MTNLNYQQTHFVMSAPDIRHLPSDTGIEVAFAGRSNAGKSSALNTLTNQKSLARTSKTPGRTQLINLFEVADGKRLVDLPGYGYAEVPEEMKRKWQRALGEYLEKRQSLQGLVVLMDIRHPLKDLDQQMIEWAVDSNIAVLVLLTKADKLASGARKAQLNMVREAVLAFNGDVQVETFSSLKKQGVDKLRQKLDTWFSEMQPVEETQDGE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: ULAE_SALHS
Sequence: MLSKQIPLGIYEKALPAGECWLKRLTLAKELGFDFVEMSVDETDERLSRLDWSREQRLALVSAVAETGVRVPSMCLSAHRRFPLGSEDDAVRTQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQQANDETRCRFRDGLKESVDMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAENPAAEVAKARDWVKARMASAGLVEAA
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: CEMA_CUSEX
Sequence: MTKKKAFTPILYLSFIVFLPWWIYFSFNKCLGSWITNWWNTRESEIFLNDLQEKSILEKLIELEEFLFVDEILKKNSETHPQEFHTGIHKEAIQFIKIQNESYIHMILRLSTNLICVVIISGFYIWRNETLVILNSWSREFLYNLSDTVKVFSILLLTDLCIGFHSPHGWELMIGSIYQDFGFVQNDRIISGLVSTFPVILDTILKYWIFRYLNRVSPSLVVIYHSIND
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into plastids (By similarity).
What are the official names of this protein?
Plastid envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid membrane; Multi-pass membrane protein.
Protein: ATG5_VANPO
Sequence: MDELRKLVWDGKINVQIAVNPQLLVKGINEKDVTVNLRIPRNAYLMNYIDEILNDLRKFLITDINFEELDGMFWFAYEGIPLYWNYPFGALYDSMVGIDPSIRYDQMKQCNSMMNIWKLQLNYSKEYPSGMIPIVDRVNQIQKYWMHQWKQACFVLNGTSKQVMSLSLVHSQQFWKSILMRDYITFYKIALKIIPSKPRHIPLMIHLTFPEIQIIQPICKFEDDSGNPQTLKDMLMTELPDIFSVDETPIAKVVSHGIEIPFDMPLFALYERFLSCDAFLHLSICMVTDDEMKRNKV
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy).  Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production.  Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function.  The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Autophagy protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATG5 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: PSBF_IPOOB
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVFFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MYB92_ARATH
Sequence: MGRSPISDDSGLKKGPWTPDEDEKLVNYVQKHGHSSWRALPKLAGLNRCGKSCRLRWTNYLRPDIKRGRFSPDEEQTILNLHSVLGNKWSTIANQLPGRTDNEIKNFWNTHLKKKLIQMGFDPMTHRPRTDIFSGLSQLMSLSSNLRGFVDLQQQFPIDQEHTILKLQTEMAKLQLFQYLLQPSSMSNNVNPNDFDTLSLLNSIASFKETSNNTTSNNLDLGFLGSYLQDFHSLPSLKTLNSNMEPSSVFPQNLDDNHFKFSTQRENLPVSPIWLSDPSSTTPAHVNDDLIFNQYGIEDVNSNITSSSGQESGASASAAWPDHLLDDSIFSDIP
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Transcription factor MYB92, Myb-related protein 92, AtMYB92.
What are the subcellular locations of this protein?
Nucleus.
Protein: THIC_PELPB
Sequence: MTNVTENITCPVKRIECIPPEKIYSKGTIFPLEVGMKRVKLSKTYFCNGQEFSSLPLYDTGGPYSDPSVSIDPEKGLPPIRKSWGFQRDEKAASSITQMHFARKGIITPEMEYVSIRENQQLEEWISSFSRGGAKVSPITPEFVRQEIAEGRAIIPANINHPELEPMIIGRKFRVKINANIGNSALGSSIEEEVEKAVWSCRWGADTVMDLSTGANIHQTREWILRNSPVPIGTVPMYQALEKAGGKAEALTWELYRDTLIEQAEQGVDYFTIHAGILLEHLPFAEKRLTGIVSRGGSIMAKWCKYHKEENFLYTRFEEICKILQRYDIAVSLGDALRPGSIIDANDEAQFGELKVLGELTKVAWKYEVQVMIEGPGHVPLHMIRENMDKELAYCHEAPFYTLGPLITDIAAGYDHINSAIGGALIASFGCSMLCYVTPKEHLGLPDRNDVREGVIAHKVAAHGADLAKGNPVSWLQDELMSRARYSFAWEDQFNLSLDPEKIRAVHAQSMAARGHTEKNPHFCTMCGPDFCSMKKSKEAAEQE
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: KPRS_METMA
Sequence: MEYIKTATEVYILKIIGGPASQLLASRTARALGTEPVLCEFNRFPDGELYLRIAEEIENEKVTLIQSTPTDSDFVALLQLIDACEGAAEINVVIPYMGYARQDKKFKSGEPVSARAIARCINADRVFTINIHEKSVLEHFPCPAENLDAAALIGSYVAGFGLERPMLVAPDEGARGLVKNVASGHGFDHDHLQKTRLSGDTVVIKTKNLDVTGRHVVLVDDMIATGGTMAESIRMLKSQGAIDVHLACVHPVLTRNAALRLFHAGVKDIIGTDTLEKAESKLSVAPLIAEALSGY
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_FRATN
Sequence: MIFYNSLSGQKEQFKPIEANKIKMYACGVTVYDDCHIGHARTYIAFDVINRYFKYRGYDVTLVRNITDIDDKIIKRANENGESTTELVERNIKAMHDVFARLNILKPSKEPRATETIPEMVAMIETLIKKGYAYQGANGDVFYRVTKFADYGKLSKQNLEALQQGSRVDVVEEKENPMDFVLWKMAKEGEPAWDSPWGAGRPGWHIECSAMSKKLLGDTFDIHAGGSDLRFPHHENEIAQSEACNECTFANYWLHSGMVKVNAEKMSKSLNNFFTIVEVLEEYHPEVVRYFLASTVYRSEINYSKENLENAKASVERLFNALRDIEPIEVNLPDDASEYEEKFIKAMDNDFNTPEALAVLFSLAKEINTLKTTNKYKASGYAYLLRKLCDVLGILFTDIEEYFKQGDGVDASEIEKLIAERTQAKKDKNYARADEIRNQLQQQGIILEDSATGTTWKKG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XLRS1_TAKRU
Sequence: MHLPREAFLLALAGAFIFPSSQQEKRTQRDLRVVCFYQKDFRNGTKAEQWGKKTPTQIWRGCMSVCNAIVVCLFELGVSETWNSKSCKCDCEGGESPTEFPSIRTGSSMVRGVDCMPECPYHRPLGFEAGSISPDQITCSNQDQYTAWFSSWLPSKARLNTQGFGCAWLSKFQDNTQWLQIDLIDAKVVSGILTQGRCDADEWITKYSLQYRTDEKLNWIYYKDQTGNNRVFYGNSDRSSSVQNLLRPPIVARYIRILPLGWHTRIALRLELLLCMNKCS
What is the function of this protein?
Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides.  May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells.  Required for normal structure and function of the retina (By similarity).
What are the official names of this protein?
Retinoschisin, X-linked juvenile retinoschisis protein homolog.
What are the subcellular locations of this protein?
Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Binds to phosphatidylserine- containing lipid membranes and embeds itself partially into the lipid bilayer. Lipid-binding requires the presence of Ca(2+) ions.
Protein: PYRDB_CALS4
Sequence: MNLSVEIGKIKLKNPVITASGTFGFGREYSEYIDLNKLGAIVVKGLTVKPREGNPPPRLFETASGILNSIGLQNPGVDAFIERELPFLKSFDVPVIVNIAGETVEEFVYMAEKLDIEGIEGIEINVSCPNVKKGGMAFGVNPDDIFDITRKVRKATSKTVIVKLTPNVTDIKVCAKAAEKGGADAISLINTVAGMAVDIDKRRPVFENVIGGLSGPAIKPIALKMVYEVVTVVSIPVIGMGGIMNYKDALEFLIVGARAIAVGTCNFVNPYCTVEIIDGIKKYMEENEIEDINEIIGSIKI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPBE_BACSU
Sequence: MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQREQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYEVVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEATAAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRAYNHLNGNDVYTGQVLDIPLMDE
What are the official names of this protein?
Uncharacterized protein YpbE.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DNAA_COREF
Sequence: MSQNSSSLLETWRQVVEDLNALSQQQDSGIPPLTPTQRAYLNLAKPIALVDGYAVLSTPHALAKNAIEHDLGESLTKVLSMRMGRSFSLAVSVEPSRDGEDPNAPPAPRQQELNYPYPGQGPQSPQGQQGQQGQHPVQQEVRAHAPAPHQQGQHQAAQHQPPANQAPGQYVVGGERGQASQSAGAWEQTHSMPAFDQGFDPSPAPVEPPPQPAHPLRIPRETPAHNPNREVSLNPKYTFENFVIGPFNRFANAAAVAVAESPAKAFNPLFISGGSGLGKTHLLHAVGNYAQELQPGLRIKYVSSEEFTNDYINSVRDDRQESFKRRYRNLDILMVDDIQFLAGKEGTQEEFFHTFNALHQAEKQIILSSDRPPRQLTTLEDRLRTRFEGGLITDIQPPDLETRIAILMKKAQADGTHVDREVLELIASRFESSIRELEGALIRVSAYSSLINQPIDKEMAIVALRDILPEPEDMEITAPVIMEVTAEYFKISVDTLRGAGKTRAVAHARQLAMYLCRELTDMSLPKIGDVFGGKDHTTVMYADRKIRQEMTEKRDTYDEIQQLTQLIKSRGRN
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHEB_HALSI
Sequence: MAQTPPPESAPSTDSEPETALETARRQLQAAAEHVDIADGVIERLTHPTRVVQVSVPVERDDGTVTVYDGYRAQHDDVRGPYKGGLRYHPGVSAEECVGLSMWMTWKCAVMDLPFGGAKGGVVVDPKTLSADEHERLTRRFAAELRDEVGPSQDIPAPDMGTDAQTMAWFMDAYSMQQGETVPGVVTGKPPVAGGSHGRAEAPGRSVAIATREAINYYDIPIDDATVAVQGYGSVGANAALLLDDWGARVVAVSDVNGGVLDTDGLDTHAIPSHGNQPAAVMRHDAPNTLTNEELLELDVDVVIPAAVGNVITAANADRIQADIVVEGANGPTTSAADRILEERAVPVIPDILANAGGVTVSYFEWLQDINRRTWSPERVRDELESEMLSAWNAVRSEVDDGDLSWRDAAYVVALQRIGRAKEARGLWP
What are the official names of this protein?
Glutamate dehydrogenase B, GDH B.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: Y2225_SALRD
Sequence: MSILRSSRLLQILLGIIGVVFTVLLVTPGLVVEYFWLSELDYSSVFWTIRGAQVLLFVLVFLVAGLYFGGNFRVLIGNIPPLWASRWAQEGEAPEVGGEPLTRDRLQRLGYVVAGVLSLLFAAGFSGRWNDLLRFWYAGSYGQADPVYGVDLAFYMLELPFLQSLQSAVVGLAFLGLLALVTGYVIAGQIGIQDGGFEADSGALRHLGANLIFLLLGWAWGFYLDLYELLQEGGGAVYGAGYTDVNVVIPALYVMVAATLVLAGLVGLNLYRRRLRLLGIGGAGYLVLLVGGLVLAPSLVTQLTVLPSELQVERPYLENNIDMTREAYALGDFKERSYPAQPDLPADAVEQNEETIDNVRLWDPRLLIDTYRQLQEIRLYYEFYSVDVDRYMLDGDYRQVMVSPRELTQQLPEDTWDNRHVRFTHGYGSVSNLVAREGSEGSPEFLTQDIPPQSKYESLDVDNPALYYGERTPTYRIVPAGVPGDSLELDYPRSGENKYTRYGGEGGVSVGSFWKQLLFSYYMGDFNILLTDYIQDDSQIQFWNQVEERVRHVAPFLKLDKDPYLVHGDDRHYYIADAYTTSNSFPYSEPIRGQQGYQGTRYIRNSVKVVVDAYNGDVSLYVSNPEDPIIQTYQRIFPDLFQPLDAMPELLQNHIRYPQDFFEIQMERYRRYHQTQPQVFYNNEDLWTRPQEQYANQQRKMEPYYILTDLPGKDDAGLEFMLMLPMTPDGRDNMIGWVAARSDPPNYGEVVVYELPKDRLIRGPNQIESRIDQDTEISQQLSLWDQRGSSVIRGNLIVVPIEESFLYVEPIYLIADEIQIPEMQRVIAATDQDVAMKRTLRQSLNSVLGEQVVETRDQALAQMQQAAQTAQAASPEQVEGLERAKELIQEARDALQGGDFATFGDRFDELQQVLNDVPLPDTTGTVPPPTSSDTTGTMTAPTGDVSEVTGGS
What are the official names of this protein?
UPF0182 protein SRU_2225.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRPA_STRZJ
Sequence: MPKTLTEKLNAIKAAGKGIFVPYIMAGDHEKGLDGLGETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGIERQKELIEGAEGFVYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKALHQGEPIQDFIKQAVAYQK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RL6_METM5
Sequence: MPVAALIREEIEIPENVNVEINGNTVAVKSGAKELRRDLMYPGIEISTEDGKVVIECTFPRKVQTAIVGTYRSHIQNMITGVTDGFEYKLVIRYAHFPMKVSAKGNTVTIDNFLGEKYTRTAKIMDGVTVKVSGEEVIVSGANKEFVGQTAANIEQATKVKGRDTRIFQDGIYIVEKAGKVL
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: CCMA_LEGPL
Sequence: MLDVIELDFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEILFERQSIKKDLCTYQKQLCFVGHRSGINPYLTIRENCLYDIHFSPGAVGITELCRLFSLEHLIDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDELSLLTIITKIQEHRAKGGAVLLTSHQDLPLNKADYEEYHL
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ARLY_STRTD
Sequence: MAENHKLWGGRFEASLEKWVEEFGASISFDQKMAEFDLKGSIAHVTMLGETGIIAQEEALQIKQGLEELLEEYKAGKLEFDVSNEDIHMNIESLLTAKIGPVAGKLHTARSRNDQVATDMHLYLKAKLVEVIEKIDNLRNTLVSLADKHTYTIMPGYTHLQHAQPISFGHHLMAYYNMFTRDSERFEFNIKHTDISPLGAAALAGTTFPIDRNMTSDLMGFAKPYSNSLDAVSDRDFILEFLSNSSILMMHMTRICEEIINWCSNEFKFVTLSDTFSTGSSIMPQKKNPDMAELIRGKSGRVYGNLIGLLTVMKSLPLAYNKDLQEDKEGMFDTVETITVAIDILAGMLNTMTVNDKHMAESTEKDFSNATELADYLATKGLPFREAHEIVGKLVLECTKAGYYLQDVPLERYQEVSDLIEEDIYETLKSHTAVERRHSLGGTGFDQVKWQIKEAQQSLNK
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA2_PORGI
Sequence: MITILGPTACGKTRLAVSLAYRLETEIISADSRQIYRGMDIGTGKDLADYQVGGTTIPCHLIDIRPAGDKYNLFAYQHDFHQAYASILARGMDPILCGGTGMYIEAVLKGYHLPDVPPNPTLRDRLQGKSLTELTLILAAYGPLHNKTDVDSAQRAIRAIEIAEYIKNNPVESTEFPPIDSLIIGLDLDRDTRRKRITDRLHARMHEGMIEEVKGLLDSGIPAEDLIYYGLEYKFVTLYLTGQTDYESMFTGLETAIHQFAKRQMTWFRGMERRGFLIHWIDALLPADEQCEAVMKLYGANG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase 2, Dimethylallyl diphosphate:tRNA dimethylallyltransferase 2, DMAPP:tRNA dimethylallyltransferase 2, DMATase 2, Isopentenyl-diphosphate:tRNA isopentenyltransferase 2, IPP transferase 2, IPPT 2, IPTase 2.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: MTNN_BACCZ
Sequence: MRIAVIGAMEEEVRILRDKLEQAETETVAGCEFTKGQLAGHEVILLKSGIGKVNAAMSTTILLERYKPEKVINTGSAGGFHHSLNVGDVVISTEVRHHDVDVTAFNYEYGQVPGMPPGFKADEALVALAEKCMQAEENIQVVKGMIATGDSFMSDPNRVAAIRDKFENLYAVEMEAAAVAQVCHQYEVPFVIIRALSDIAGKESNVSFDQFLDQAALHSTNFIVKVLEELK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: WTX1B_NEOAP
Sequence: FLGALLKIGAKLLPSVVGLFKKKQQ
What is the function of this protein?
Membrane-perturbating peptide with multiple activities (PubMed:34302796).  It is insecticidal, since it induces reversible paralysis in insects (L. cuprina) after 1 hour, but fails to kill flies (PubMed:34302796).  It shows a relatively strong and broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria (MIC<20 uM) (PubMed:34302796).  It is also anthelmintic, since it potently inhibits the larval development of the major pathogenic nematode of ruminants (H. contortus, IC(50)=2. 8 uM) (PubMed:34302796).  Interestingly, only at 10 uM, it increases adult males motility of the other nematode B. malayi for 24 hours post-treatment, followed by a reduction in motility for the rest of the experiment (PubMed:34302796).  It shows cytotoxic activity against HEK293 cells (EC(50)=4-6 uM) and induces hemolysis in human erythrocytes (EC(50)=40-62 uM) (PubMed:34302796).  In addition, it causes an important increase in intracellular calcium concentration on neuronal and epithelial cell lines, which supports a non-specific membrane perturbation mechanism of action (PubMed:34302796).  In vivo, it induces pain by intraplantar injection into mice, suggesting a defensive function against vertebrate predators (PubMed:34302796).
What are the official names of this protein?
M-poneritoxin-Na1b, M-PONTX-Na1b, Poneratoxin, Ponericin Pa II2, U1-poneritoxin-Na1b, U1-PONTX-Na1b.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Medium-length antimicrobial peptide (group 3) family. Ponericin-W subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Adopts an alpha- helical conformation in membrane-mimetic environments.
Protein: MYHW_BOMMX
Sequence: MIFKYIVAVSFLIASGYARSVKNDEQSLSQREVLEEESLREIRGIGGALLSVGKSALKGLAKGFAEHFGKRTAEDHEVMKRLEAVIRDLDSLDHSEEASERETRGFNQEEIANLFTKKEKRILGPVLGLVSNAIGGLIKKIG
What is the function of this protein?
Maximin-Hw shows antimicrobial activity against bacteria and against the fungus C. albicans.  Shows strong hemolytic activity (By similarity).
What are the official names of this protein?
Maximins y/Hw.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HPRK_LEVBA
Sequence: MTESVTVAELVKANRLDVYTGKDNLDRKITTSDISRPGLELTGYFNYYPAKRVQLLGITETSFAKGMSHKELLNVMRKMCQPETPAFVISTQLDPPEELTQSAEEAGIPILGTKLTTSRVLSNMTNFLEGKLAERQSVHGVLVDIYGVGVMITGDSGVGKSETALELVKRGHRLIADDRVEVYQQDEQTLVGAAPAILSHLLEIRGIGIIDVMNLFGAGAVRSETDIDLIVHLELWQDDNHFDRLGNNSETQRFFDVVVPKISIPVKTGRNLAIIIEAAAMNFRARSMGYDATKVFDDNLKRLIKQNANKS
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.