PharMolix/UniProtQA huggingface dataset:
Protein: RL5_BOVIN
Sequence: MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFSAEVHRKHIMGQNVADYMRYLIEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs.  It also couples ribosome biogenesis to p53/TP53 activation.  As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53.
What are the official names of this protein?
60S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn.
Protein: RF1_MESFL
Sequence: MNPKTYEALETMQKRVDQIDKDLQSEEIVSDVKKMLELNKERANLIEVVEKFIEYKTIIQSIADAKEILGNEKDAEMIELAKMELSENEDAVEPIVAIIEELLLPKDPNDDKNVIVEIRGAAGGDEANIFAGDLLRMYKLYAETQNWKITMLDANSSEAGGFSQVSFMVKGDRVYSKLKFESGAHRVQRVPKTEAKGRIQTSTATVAVLPEMSDVEIEIKNSDLRIDTYRSSGAGGQHVNTTDSAVRITHIPTGVVAASQDGRSQHDNKDIAMTMLRARIYEAELEKQQAEADATRKNAVGTGARSEKIRTYNYPQNRVTDHRVGLTLNKLDQVMEGKIDDFIIALVNDEQRQKVEAQLQDNE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_DICT6
Sequence: MPKYYIITYGCQMNKSDSEKVAGILENLGYTPSEKMEEADIILLNTCSVRERAEEKVFGKLGELRKLKKRNQNLLIGIFGCMAQRMKEELIEKFPHVDFVLGSYKFTELPKILESLDGKKKVVLAEDIPSPQDVDFRVIKRENKFQAWIPIIYGCNNFCTYCIVPYLRGREKSRDPEEIIREVEYLASQGVVEVTLLGQNVDSYGKDLGNVDLADLLVEIHRIPRIKRIRFLTSHPRDVSDKLIRVVATHPKVCPHWHLPLQAGSDRILRRMGRGYTYSEYKALIEKIRAEIPKASFSTDIIVGFPGEEEEDFLATRRALEEIKFDTVNLAIYSKRPGTPAANYEDLIPYETKKRWFDELENLQRKIIYEKNLSRVGKEEIVLAEEVNPKNPRELSGRTENYRLVFFEAEKELIGKFLLVKITEARLWSLKGEVIREVDL
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_CERS4
Sequence: MTDLTPREIVSELDRFIIGQKEAKRAVAVALRNRWRRKQLADDLRDEVYPKNILMIGPTGVGKTEISRRLARLAKAPFLKVEATKFTEVGYVGRDVDSIIRDLVDAAIVETRARMREDVKARAAKAAEDRVIEAVAGRDAREQTREMFRGKLKRGELDSTVIEIDVADTSNPMQMLDPTGQGQMGMMNLGEIFGKAFGGRTQRRKMTVAESHDILMNEEADKLLDDEVVKATALEAVQQNGIVFIDEIDKVCARSDMRGADVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHIAKPSDLLPELQGRLPIRVELRALTEEDFVRILSETDNALTLQYKALMQTEKVGITFTEDGIAALASIAAEVNRSVENIGARRLYTVMERVFEELSFHAPDRSGEEVTVDAAYVEKNLGELARSSDLSRYVL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_NITEU
Sequence: MSYSFAEKKRIRKSFAKRASILPFPFLLATQIQSYTDFLQAEIAPGKRKNQGLQAAFNSVFPIESHSNNARLDFISYMLGSPVFDVKECQQRGLTYAAPLRARVRLTILDKEASKPTVKEVKEQEVYMGEIPLMTDTGSFVVNGTERVIVSQLHRSPGVFFEHDRGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDYVYFRIDRRRKMPVTTLLKAMGYSPAQILADFFEFDHFILVDNKIFFNLIPERLRGELAGFDIVSEDGKVFVQKDKRITAKHVRDLQQANLTKIPVPEEFLLGKILAADLVDKETGEIIALANSEISETLLGRIRQTQSSEISTLFVNDLNYGPYISQTLRIDETTDQMSAQVAIYRMMRPGEPPTEEAVLALFNGLFYSPERYDLSVVGRMKFNRRVGREELTGSTTLSNDDIIDVIKILVELRNGRGEIDDIDHLGNRRVRSVGELAENQFRAGLARVEKAVKERLSQAESENLMPHDFINAKPVSSAIREFFGSSQLSQFMDQTNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYARTNEYGFIETPYRMVRNGRVTEEVVYLSAIEESQYVIAQANANFDQNGVFTDEVVSCRHKNEFTLASRDQIEYVDIAPAQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRAEKPLVGTGIERVVAVHSGTAVRTIRGGVVDYVDASRIVIRVHDAEARAGEVGVDIYNLTKYTRSNQNTNINQRPIVRMGDVLSRDDVIADGASTDLGELALGQNMLIAFMPWNGLNFEDSILISERVVSDDRFTSIHIEELAAVSRDTKLGTEEITADIPNLSERQRARLDESGIVYIGAEVEAGDVLVGKVTPKSETQLTPEEKLLRAIFGEKASDVKDTSLHVPAGISGTVIDVQIFTREGVDRDKRSKQIIADELGRFKKDLADQMRIVEADAFQRAERLLTGKVAAGGPKKLAKNSTITRDYLENVEKHHWFDIRLVDENTSLQLEQIKDSLVQKRKLFDLAFEEKHRKLSQGDELPPGVQKMVKVYIAVKRRLQSGDKMAGRHGNKGVISKIVPIEDMPYMADGTPVDVVLNPLGVPSRMNIGQVLEVHLGWAAKELGKRVNEMLASQRNVSDIRDFLNKIYNNSGKQEDLTSLEDDEVLALARNLSSGVPFATPVFDGAHESEIKQMLKLAGLPESGQTTLYDGRTGEAFDRPVTVGYMHVLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYTLQEMLTVKSDDVNGRTKVYESIVKGDHKIDAGMPESFNVLVKEIRSLGLDIDLEEH
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: GZF3_CANAL
Sequence: MSMSDIQQRPQIPTTTTAAVAAAASTNVNTGAATTSTATTGNTPTTTPTSPIENISKVPVKPSVDVPVKPKLEQQQQQQSEQSSKPPPPPPEQQQQHQLPTPPIKPPKTGTTSSSSSTTTSSATSSKISMSGPVCGNCQTQTTPLWRRDETGQVLCNACGLFLKLHGRPRPISLKTDTIKSRNRVKQNGSNSQSSKSSGANTPELKSKEGKSGKKSPKSKKKSLGNGNGNGNSSHDHNTLTPLLPATSNNTPTFKSTTSQSQHQQNQNHHHQHHNHHHHLPNHVLQTHQVPLHYPSSTPTQFAPGLQRITSPLLLSTTSSSSSIRTEPNNNNTSKLTPIQAAAGALENMSNELGPSATFKKGNNINGISLMNKTKKDVSSINGSSTSLSSSSASSSIFSSVAPSTSSSSSLSNGTTINNPAPKLPTLGSKISSPSSQPFTRSTTPLQTLPPLHKIASHESSLPPLHNISTYNNNNSGGGADGGQQSMANYSQTNRSPINGNQDNNNNNNNNNNNNNNGNNNGNNNSNNNGNNFTASAHEVTLLKTRISELELVNDLYRTRIMELEAMEQAARLRENSMKKRLDEVMNLQINYQNLLNNNGGMSSQTQPQPSQQPQQAGQYYSNNNNNNNNDQGSQSISPNVSITGSTTITSPNSRSKIISETTPTHHQQQQGGVGAGDNESIILPPLKRNRTDELTDANGNGNGNDNKKVKI
What is the function of this protein?
Probable transcription factor involved in response to fluconazole, LiCl, and copper.
What are the official names of this protein?
Transcriptional regulator GZF3.
What are the subcellular locations of this protein?
Nucleus.
Protein: HDAC1_MOUSE
Sequence: MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
What is the function of this protein?
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10615135, PubMed:15542849, PubMed:21960634, PubMed:30279482).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10615135, PubMed:15542849, PubMed:21960634).  Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10615135, PubMed:21960634).  Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity).  Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3 (By similarity).  Deacetylates SP proteins, SP1 and SP3, and regulates their function (By similarity).  Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (By similarity).  Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (By similarity).  Deacetylates TSHZ3 and regulates its transcriptional repressor activity (By similarity).  Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (By similarity).  Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (By similarity).  Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:17707228).  Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (PubMed:15226430, PubMed:24736997).  Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (PubMed:15226430).  In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:30279482).
What are the official names of this protein?
Histone deacetylase 1, HD1, Protein deacetylase HDAC1, Protein decrotonylase HDAC1.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TTGE_PSEPT
Sequence: MSRFFIDRPIFAWVLAIIAMLAGALSLTKMPISQYPNIAAPAVSIQVVYPGASAKTVQDTVVQVIEQQLNGLDGFRYMAAESASDGSMNIIVTFEQGTNPDIAQVQVQNKLQLATPRLPEEVQRQGLRVVKYQMNFFMVVGLVDKTGKMTNFDLGNLIASQLQDPISRINGVGDFLLFGSPYAMRIWLDPGKLNSYQLTPGDVAQAIREQNVQVSSGQLGGLPTRSGVQLNATVVGKTRMTTPAEFEEILVKVKADGSQVRVKDLGRVVLASENFAISAKYRGQDSAGLGLRLASGGNLLETVKAVKAELEKQKAYLPEGVEVIYPYDTSPVVEASIDSVVHTILEAVVLVFLVMFLFLQSLRATIIPTLAVPVVLLAAFALLPYFGISINVLTMYAMVLAIGLLVDDAIVVVENVERLMHDEGLSPLEATRKSMGQISGALVGIGMVLSAVFVPMAFFGGSAGIIYKQFAVTIVICMSLSVLVALIFTPALCATILKAPENDAHHEKKGFFGWFNRSFDRNSARFERGVGGILKHRGRYLLIFALITAGTGYLFTQIPKAFLPSEDQGLMMTEVRMPLNASAERTEVVLQEVKDYLLKEEGQLVDHVMTVNGFNFAGRGQNSGLVLVVLKDWAARQAAGEDVLSVAERANARFARIKDATVMAFVPPAVLEMGNAMGFDLYLQDNLGLGHESLMAARNQFLELAAENPSLRAVRPNGKDDEPQFQVKIDDEKARALQVSIASINDTMSAAWGSMYVNDFIDLGRVKRVYIQGVDSSRIAPEDFDKWYVRNALGEMVPFSAFATGEWIHGSPKLERYGGISAVNILGEPAPGFSTGDAMIAIAQIMQQLPSGIGLSYNGLSYEEIRTGDQAPMLYALTVLIVFLCLAALYESWSVPMSVILVVPLGIFGAVLATLWRGLEADVYFQVGLMTTVGLSAKNAILIIEFAKELYEKEGVPLVKAAIEAARLRLRPIIMTSLAFTFGVLPMARATGAGAGSQHSIATGVVGGMITATVLAVFFVPLFYVVVVKVFERNKKPAALAEEELA
What is the function of this protein?
The inner membrane transporter component of an inducible organic solvent efflux pump.  Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene.  Is not involved in antibiotic or AMP efflux.
What are the official names of this protein?
Toluene efflux pump membrane transporter TtgE.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOA_RHOPS
Sequence: MTIQKNWQELIRPNKLQVSPGSDATRFATLVAEPLERGFGQTLGNALRRVLLSSLQGAAVQSVQIDGVLHEFSSIAGVREDVTDIVLNIKDISLKMQGEGPKRMVVKKQGPGVVTAGDIQTVGDIVVLNPDLQICTLDEGAEIRMEFTVNTGKGYVAAERNRPEDAPIGLIPVDSLYSPVRKVSYKVENTREGQILDYDKLTMTVETNGALTPDDAVAFAARILQDQLNVFVNFEEPRKEVTQEIIPDLAFNPAFLKKVDELELSVRSANCLKNDNIVYIGDLVQKSEAEMLRTPNFGRKSLNEIKEVLAQMGLHLGMEVPGWPPENIDELAKRFEDHY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: PIMT2_GEOUR
Sequence: MINLDIARRRMVENQIVARGIKDRRVIDAMLKVPRHIFVEEAMSAQAYSDSSLPIGEKQTISQPYMVALMSGMLQLTGKEKVLELGTGSGYQAAILAELADRVYTVERIRPLALRARKALDSLGYLNVNLKIGDGTDGWASEAPFDAILVTAGAPDVPMHLIDQLAVGGKLVIPVGNQSEQTLVRITKGENGAVSREDSIGCRFVKLIGRYGWSGED
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase 2, L-isoaspartyl protein carboxyl methyltransferase 2, Protein L-isoaspartyl methyltransferase 2, Protein-beta-aspartate methyltransferase 2, PIMT 2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_PSYA2
Sequence: MGQKVHPIGIRLGVVKKHNANWYASPKQYSEYLINDIQVREYLRKKLDSAMISKIMIERPTGAAKITIATARPGIVIGKKGEDIERLQKELTKMMGVPAQVNIEEITSPDLDAHLVAEGIASQLERRVMFRRAMKRAVQNSMRSGAKGIKVELSGRLGGAEIARTEWYREGRVPLHTLRADIDYSSVRAETTYGTIGVKVWIFRGEILDGMNSVYNPVKEEQTRAPKRRGRGNGNRRNTDRG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CTRD_NEIMA
Sequence: MISVEHVSKRYLTRQGWRTVLHDISFKMEKGEKIGILGRNGAGKSTLIRLISGVEPPTTGEIKRTMSISWPLAFSGAFQGSLTGMDNLRFICRIYNVDIDYVKNFTEEFSELGQYLYEPVKRYSSGMKARLAFALSLAVEFDCYLIDEVIAVGDSRFADKCKYELFEKRKDRSIILVSHSHSAMKQYCDNAMVLEKGHMYQFEDMDKAYEYYNSLP
What is the function of this protein?
Putative ATP-binding protein, and an energy-coupling component of capsule polysaccharide export apparatus.
What are the official names of this protein?
Capsule polysaccharide export ATP-binding protein CtrD, Capsular-polysaccharide-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SHSA1_XENLA
Sequence: MEFIVLLTVCALLGLSCGQHGEYCHGWTDSYGIWRPGFQCPERYDPPEATFCCGSCGLKYCCSTVESRLDQGLCPNEEDLRDGVPSIELPPTVPTYFPFLLVGSIFVSFVILGSLVGLCCCKCLKPEDDTQVSGPAPIQSRLLDQDPSTDTSRHSSSSSASMPRPPIGARPQNLCSLGAENINLYMNMPPTFPMMGCPQNAQFMHPGTAGPSFMQPPFINYAVPAEHAIIMAPAPYIDARNCYGQTSNIYCQVPQQNDQTVCSGSPSKC
What is the function of this protein?
Required for head formation during gastrulation.  Functions as an inhibitor for the caudalizing signals wnt and fgf, does not inhibit bmp, activin and nodal signaling in head formation process.  Induces retention of fzd8 in the endoplasmic reticulum and inhibits trafficking of fzd8 to the cell surface.
What are the official names of this protein?
Protein shisa-1.
What is the protein family that this protein belongs to?
Belongs to the shisa family.
Protein: RS19_THEPX
Sequence: MSRSVKKGPYVDPKLLKKIVEMNKKNEKKVIKTWSRSSTIVPEMVGHTIAVHDGRKHVPVYITEAMVGHKLGEFAPTRTFHGHADTEKTSKVK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: AL1L1_PONAB
Sequence: MKIAVIGQSLFGQEVYCHLRKEGHEVVGGFTVPDKDGKADPLGLEAEKDGVPVFKFSRWRAKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIINAPQHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQKLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMILASNFFKGAASSALELTEAELVTAEAVRSVWQRILPNVLEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTIRIPHQLFIGGEFVDAEGAKTYETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLLYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGDPLDRDTDHGPQNHHAHLMKLMEYCQRGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDVDTVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY
What is the function of this protein?
Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.  May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde.
What are the official names of this protein?
Cytosolic 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PURL_SYNJB
Sequence: MPYTLEDLKAHGLSPAEYQQIQQQLGRDPNPNELAMFGVMWSEHCCYKNSRPLLKNFPTTGERVVVGPGENAGVVDLGEGDWLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTLGARPIALLNSLRFGPLTDPRNRRLMARVVEGIAHYGNCVGVPTVGGEVAVDPCYSGNPLVNVMALGLLETPAVVKSAARGVGNPVLYVGATTGRDGIRGASFASAELKEDAQQDRPAVQVGDPFLGKCLIEACLEAFATGAVVAAQDMGAAGITCSTAEMAAKGGVGIRFDLDRVPARESGMAAWEYLLSESQERMLLVVQKGREAEVMEIFHRWGLQASVAGEVIAEPLVEIWHQGSCVVQVPVRALAEDTPVYVRPVLPEPPAYVQAAWQWDPATLPPCDCQGIHLAQATLAWKEVLLQLLASPTLASKAWIYRQYDHQVQNNTVLWPGQGDAAVIRIRSQRFGVGEVPPLRASRKAIAATLDGNGRWVYLDPYEGAKAAVAEAARNLTCVGADPLAVTDNLNFGNPENPVVYWQLALACRGIGDACRALGTPVTGGNVSLYNETLTPQGSQAIYPTPVIGMVGLIPDLKCICGQGWQQEGDLIYLLGSQALTSLGGSEYLAVIHQQVTGRPAPVDLELEKRVQAACRHGIRQGWVRSAHDCSEGGLAVALAEACLSGGRGATLSLAPGSLRWDQALFGEGSSRILVSVDPAQRSAWEAYLEAQLAGQWQLLGEVGSPADPLLLRTAEEDPLLVVSLAAMQAAYHGAFSD
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_FRATW
Sequence: MRHRKQGRKFGRTSSHRKAMFKNMSASLINHELIKTTLPKAKELRTIVEPLVTLAKREHKLRQELDTNSNEFKAQSVALRRQAFDFLRNKAAVTKLFEEFGARYAERAGGYTRILKCGYRFGDKAPMAFIELVDRPQVEEAADEE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: VATA2_EQUAR
Sequence: AEVPMPLRQLTMTLPDGREESVMERTTLVA
What is the function of this protein?
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase.  V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase catalytic subunit A isoform 2, V-ATPase subunit A 2, Vacuolar proton pump subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: RL28_THEM4
Sequence: MAKCQVCGKGPVTGKNVSHSNRRTNRWFKPNLQKVRVITDEGKIKRMWVCTDCLSAGKVKRYVSTKVEAQ
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: CM3A_CONGE
Sequence: MMSKLGVLLTICLLLFPLTALPMDGDEPANRPVERMQDNISSEQYPLFEKRRDCCTPPKKCKDRQCKPQRCCAGR
What is the function of this protein?
Mu-conotoxins block voltage-gated sodium channels (Nav).  This toxin potently blocks rat Nav1. 4/SCN4A (IC(50)= 19-110 nM) (PubMed:1654319, PubMed:1326324, PubMed:10627583, PubMed:21652775, PubMed:30360356).  It also moderately blocks rNav1. 1/SCN1A (Kd=260 nM), rNav1. 2/SCN2A (IC(50)=2. 7-17. 8 uM), and mNav1. 6/SCN8A (IC(50)=680 nM) (PubMed:10627583, PubMed:21652775).  The inhibition is reversible.  In vivo, induces paralysis to an isolated skeletal muscle preparation from frog (cutaneous pectoralis) within a few minutes (PubMed:2410412).
What are the official names of this protein?
Mu-conotoxin GIIIA, G3.9, Geographutoxin I, GTx-I, Myotoxin I.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CARD8_HUMAN
Sequence: MEKKECPEKSSSSEEELPRRDSGSSRNIDASKLIRLQGSRKLLVDNSIRELQYTKTGIFFQAEACVTNDTVYRELPCVSETLCDISHFFQEDDETEAEPLLFRAVPECQLSGGDIPSVSEEQESSEGQDSGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQAGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL
What is the function of this protein?
Constitutes the active part of the CARD8 inflammasome (PubMed:32840892, PubMed:34019797).  In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, N-terminus), preventing activation of the CARD8 inflammasome (PubMed:33542150).  In response to pathogen-associated signals, the N-terminal part of CARD8 is degraded by the proteasome, releasing this form, which polymerizes to form the CARD8 inflammasome complex: the CARD8 inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (PubMed:32840892, PubMed:33542150).
What are the official names of this protein?
Caspase recruitment domain-containing protein 8, CARD-inhibitor of NF-kappa-B-activating ligand, CARDINAL, Tumor up-regulated CARD-containing antagonist of CASP9, TUCAN.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Caspase recruitment domain-containing protein 8, C-terminus]: Inflammasome.