PharMolix/UniProtQA huggingface dataset:
Protein: PSD13_HUMAN
Sequence: MKDVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGALKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAFNSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDILT
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 13, 26S proteasome regulatory subunit RPN9, 26S proteasome regulatory subunit S11, 26S proteasome regulatory subunit p40.5.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S11 family.
Protein: HEMH_YEREN
Sequence: MKQSKLGVLMVNLGTPDAPTPQAVKRYLAEFLSDRRVVDTSPWLWWPLLRGVILPIRSPRVAKLYQSVWMDEGSPLLVYSRRQQKALAERMPEIPVELGMSYGSPNLPDAIDKLLAQGVTKLVVLPLYPQYSCSTSAAVWDAVARILKGYRRLPSISFIRDYAEHPAYISALKQSVENSFVQHGKPDRLVLSFHGIPKRYAQLGDDYPQRCEDTSRALRAEIALPAEQIMMTYQSRFGREPWLTPYTDETLKSLPSQGVKHIQLICPGFSADCLETLEEIKEQNREVFIHAGGEKFEYIPALNDDKGHIDLLEQLVRDHLSC
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_SHIB3
Sequence: MSLTRLLIRDFRNIETADLALSPGFNFLVGANGSGKTSVLEAIYTLGHGRAFRSLQIGRVIRHEQEAFVLHGRLQGEERETAIGLTKDKQGDSKVRIDGTDGHKVAELAHLMPMQLITPEGFTLLNGGPKYRRAFLDWACFHNEPGFFTAWSNLKRLLKQRNAALRQVTRYEQLRPWDKELIPLAEQISTWRAEYSAGIAADMADTCKQFLPEFSLTFSFQRGWEKETEYAEVLERNFERDRLLTYTAHGPHKADLRIRADGAPVEDTLSRGQLKLLMCALRLAQGEFLTRESGRRCLYLIDDFASELDDERRGLLASRLKATQSQVFVSAISAEHVIDMSDENSKMFTVEKGKITD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_THEVB
Sequence: MTHIDWLVQTDPLVAEMVQREVQRQQQHLELIASENFTSPAVMAAQGTVLTNKYAEGLPGKRYYGGCEFVDEVEQLAIDRAKELFGAAHANVQPHSGAQANFAVFLALLNPGDTIMGMDLSHGGHLTHGSPVNVSGKWFNVVHYGVHPETERLDMDQVRDLARQHRPKLIICGYSAYPRVIPFAEFRQIADEVGAYLMADIAHIAGLVASGYHPNPVPLCDVVTTTTHKTLRGPRGGLILTRDEDLGKKLDKAVFPGTQGGPLEHVIAAKAVAFGEALKPEFKAYCGQVIRNAQALAAGLQARQLRLVSGGTDNHLMLIDLRSVNLTGKEADRLMGEIHITTNKNTIPFDPASPFVTSGLRLGTPALTTRGFTEVEFAEVAEIISDRLHAPEDEAIKNRCRERVAALCAQFPLYPHLQFPQPVLA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRP_BOMOR
Sequence: MEGVLLFWKYRALFFLVLCSLVLCKVHLSQASPTSQQHNDAASLSKIYPRGSHWAVGHLMGKKSIEEYPYAYDEADRSSAAVFSEGDKPSDGYQQWKESLLNLLKMIEVNEYRNSKAMREASVYNKKFSGAEDNNLKEMLDYLYQMMNMKENTSS
What is the function of this protein?
Stimulates the release of gastrin and other gastrointestinal hormones.
What are the official names of this protein?
Gastrin-releasing peptide, GRP-29.
What is the protein family that this protein belongs to?
Belongs to the bombesin/neuromedin-B/ranatensin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle lumen.
Protein: EXP7_STRPN
Sequence: MDKNKIMGLTQREVKERQAEGLVNDFTASASTSTWQIVKRNVFTLFNALNFAIALALAFVQAWSNLVFFAVICFNAFSGIVTELRAKHMVDKLNLMTKEKVKTIRDGQEVALNPEELVLGDVIRLSAGEQIPSDALVLEGFAEVNEAMLTGESDLVQKEVDGLLLSGSFLASGSVLSQVHHVGADNYAAKLMLEAKTVKPINSRIMKSLDKLAGFTGKIIIPFGLALLLEALLLKGLPLKSSVVNSSTALLGMLPKGIALLTITSLLTAVIKLGLKKVLVQEMYSVETLARVDMLCLDKTGTITQGKMQVEAVLPLTETYGEEAIASILTSYMAHSEDKNPTAQAIRQRFVGDVAYPMISNLPFSSDRKWGAMELEGLGTVFLGAPEMLLDSEVPEAREALERGSRVLVLALSQEKLDHHKPQKPSDIQALALLEILDPIREGAAETLDYLRSQEVGLKIISGDNPVTVSSIAQKAGFADYHSYVDCSKITDEELMAMAEETAIFGRVSPHQKKLIIQTLKKAGHTTAMTGDGVNDILALREADCSIVMAEGDPATRQIANLVLLNSDFNDVPEILFEGRRVVNNIAHIAPIFLIKTIYSFLLAVICIASALLGRSEWILIFPFIPIQITMIDQFVEGFPPFVLTFERNIKPVEQNFLRKSMLRALPSALMVVFSVLFVKMFGASQGWSELEISTLLYYLLGSIGFLSVFRACMPFTLWRVLLIVWSVGGFLATALFPRIQKLLEISTLTEQTLPVYGVMMLVFTVIFILTSRYQAKK
What are the official names of this protein?
Probable cation-transporting ATPase exp7, Exported protein 7.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRAA_ECOLU
Sequence: MKYDTSELCDIYQEDVNVVEPLFSNFGGRASFGGQIITVKCFEDNGLLYDLLEQNGRGRVLVVDGGGSVRRALVDAELARLAVQNEWEGLVIYGAVRQVDDLEELDIGIQAMAAIPVGAAGEGIGESDVRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_YERPA
Sequence: MVNKRMQTLLMQLRQQGIHDERLLQAIEAVPRERFVDEALAHKAYENTALPIGAGQTISQPYMVARMTELLQLTPTSRVLEIGTGSGYQTAILAHLVDHVCSVERIKGLQWQAKRRLKQLDLHNVSTRHGDGWLGWQSRGPFDAIIVTAAPPEIPDALLEQLDEGGILVLPVGEQFQTLKYVQRRNNEYHIETVEAVRFVPLVKGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_SALTY
Sequence: MRYTVALTGGIGSGKSTVADAFADLGITVIDADIIARQMVEPGQPALNAIAEHFGSELIAADGTLRRRALRERIFSHPEEKAWLNALLHPLIQQETQRQFQQATSPYVLWVVPLLVENRLYQKANRVLVVDVTPETQLIRTMQRDDVTREHVEHILAAQATREARLAVADDVIDNNGAPDAIASDVARLHASYLKLASQFVSQEKP
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHA4_HUMAN
Sequence: MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-4.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.
Protein: DAN1_YEAST
Sequence: MSRISILAVAAALVASATAASVTTTLSPYDERVNLIELAVYVSDIGAHLSEYYAFQALHKTETYPPEIAKAVFAGGDFTTMLTGISGDEVTRMITGVPWYSTRLMGAISEALANEGIATAVPASTTEASSTSTSEASSAATESSSSSESSAETSSNAASTQATVSSESSSAASTIASSAESSVASSVASSVASSASFANTTAPVSSTSSISVTPVVQNGTDSTVTKTQASTVETTITSCSNNVCSTVTKPVSSKAQSTATSVTSSASRVIDVTTNGANKFNNGVFGAAAIAGAAALLL
What is the function of this protein?
Component of the cell wall.
What are the official names of this protein?
Cell wall protein DAN1, Covalently-linked cell wall protein 13, Delayed anaerobic protein 1.
What is the protein family that this protein belongs to?
Belongs to the SRP1/TIP1 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Protein: GLPK_LACDB
Sequence: MSEQYILAIDEGTTSTREIIFNYAGQQVASVAREFTQYFPKPGWVEHQAEEIWNAVQITTSTALINSAIRPDQLAVIGITNQRETTVVWDKETGRPIYPAIVWQSRQTSDIAEKLVKDSYSEMIRQKTGLVIAPYFSATKIRWILDHLEGAQERAEKGELLFGTIDTWLVWKLTRGKVHVTDCTNASRTMLFNIHDLTWDQEILDLLKIPRTMLPEVKSNSEVYGETDPYQFFGGRVPIAGMAGDQQAALFGQLAVKPGMVKNTYETGSFIVMNTGEEPIESKNNLLTTIGYKLGDQVNYALEGSVFVAGSAIQWLRDSVKLLNSAPESEQAALESKDANEVYVVPAFTGLGAPYWDSEARGAIFGLTRGSSDKDLIKATLQSLAYQTRDVVDTMQKDSGIEIPVLRVDGGASNNNYLLQFQADLLGKKIERAADLETTGLGAAFLAGLAVGYWQDLDSLKEIAKTGAAFAPKMEEAERDRLYAGWQRAVLATRVFAHGKDF
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: SSUB_YERPS
Sequence: MTTLTHIPQGTPITLESIGKRYGNRTVLDNLQLRITAGQFVAVVGRSGCGKSTLLRLLAGLEAASDGTLLSGNALLSHAKDETRLMFQEARLLPWKKVIDNVGLGLRGHWRDDALQVLDTVGLADRANEWPAALSGGQKQRVALARALIHRPRLLLLDEPLGALDALTRIEMQGLIERLWQQHGFTVLLVTHDVSEAIALADRVLLIEEGRIGLDLAIDLPRPRRKGSAKLAALEAEVLERVLSPPQGIEASRQGIKASRQGTATSRRVAN
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CEO_CLOBH
Sequence: MKLGFLIPNHPNEKRVALLPEHVKGFNNELVIETGFGETLGISDAEYVKVGCTIASREEIFKTCEGIFSLKVLKPQDYKHIREGQIIVGWTHPEGSGKIFMEEQGIPKNLIIVDLDNIHPSIYYKDYVIPMEWIPSNFVRKNSYIAGYASTMHAVMNYGSIPTSETKVAILGSGNVSQGAFSAISKFNPDIRMFYRKTMNQLKDELEEFDIIINGIEMDNPNKHILTLEDQMRLKKNCLIIDAAANLGKAIEGARHTTASDPIYNKDGKYYYAVNNSPSIFYRQSSKAISEAFSKHVYSKELEFYLDVIAEVEEMIV
What is the function of this protein?
Catalyzes the NADPH-dependent reductive condensation between pyruvic acid and the side chain amino group of L-ornithine to form N(5)-(L-1-carboxyethyl)-L-ornithine.  To a lesser extent, can also use L-lysine as substrate (yielding N(6)-(L-1-carboxyethyl)-L-lysine), and the D-isomers of the 2 basic amino acids.  Can use alpha-keto acids other than pyruvate, e. g.  glyoxylate.
What are the official names of this protein?
N(5)-(carboxyethyl)ornithine synthase, CEOS, N(5)-(L-1-carboxyethyl)-L-ornithine:NADP(+) oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family. CEOS subfamily.
Protein: RS12_PROM9
Sequence: MPTISQLIGSERKRLTRKTKSPALKSCPERRGVCTRVYTSTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVLLRGGRVKDLPGVRYHIIRGTLDTAGVKDRRQSRSKYGAKAPKD
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: CH10_SHEON
Sequence: MNIRPLHDRVIVKRLEVESTSAGGIVLTGSAAEKSTRGEVLAVGNGRILENGTVRPLDVKVGDVVIFNEGYGVKKEKIDGQEVLILSEADLMAIVG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TKNK_MOUSE
Sequence: MRSAMLFAAVLALSLAWTFGAVCEEPQGQGGRLSKDSDLYQLPPSLLRRLYDSRPVSLEGLLKVLSKASVGPKETSLPQKRDMHDFFVGLMGKRNSQPDTPTDVVEENTPSFGILK
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.  Is a critical central regulator of gonadal function (By similarity).
What are the official names of this protein?
Tachykinin-3, Neurokinin B-like protein Zneurok1, Preprotachykinin-B, PPT-B.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL4_LACLS
Sequence: MAKVSLFKQDGSQAGEVTLNDSVFGIEPNESVVFDVVISQRASLRQGTHAHKNRSAVSGGGKKPWRQKGTGRARQGSTRSPQWRGGGTVFGPNPRSYAYKLPQKVRQLALKSVYSTKVADGKLIAVDTLDFAAPKTAEFAKVISALSIERKVLVVLPNEGNEFAELSARNLENVKVTTANSASVLDIVSADKLLVVQSALTQIEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: LSPA_VIBC1
Sequence: MSEKALTLKQSGVRWLWLAILVFIADIGIKLVVMDNMGYGWANRIEVLPFFNLLYVHNYGAAFSFLSDQAGWQRWLFTGIAFVVTGLLTYWMSKLPAKEKWNNIAYALIIGGAVGNVFDRVVHGFVVDYLDFFWGSYHWPAFNLADTTICIGAAMIILDGFRKKDANK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PKNB_BIFLO
Sequence: MSTSMPTALAGGRYQLGQLIGRGGMAEVHVALDTRLGRTVAVKIMRADLANDDIFLARFRREAHAVAQMNNPNIVNIYDSGEELVSSESGDAERLPYIVMEYVKGQTLRDIIKVNGALSQRDCEQVMLGVLNALDYSHRMGIIHRDIKPGNIMISEQGVVKVMDFGIARALDDSAATMTQSQGVVGTAQYLSPEQARGETVDMRSDLYSAGCVLYEMLTGRPPFTGDSAVAIAYQHVSEVATPPSAAVPGLPKMWDSICAKAMAKDRQNRYATASEFKTDILTYMNGGVPVAAAFNPLTDLSNMKARKEAERDLPTTPVEPHQQPTQAFNPVTGQFEQIPPANGANAAALQSRAQQRAAAAKAKKRKKIIIGSVIAAIVAVLVIVGIVFAMNGSGNKSSEDTVTIPEVCNASTSKDNIKLKLEASGLKMTEKQDTDSTEPEGTCTKMSPDAGSKVAKGSAVKVWFSAGPQSTQVPDVKERSQEEARSILESAGFKVNAAVKTEDSADIAKDMVTKTDPAAGQSVPKGTTITIYVSSGMTTVPSNLVGQSKDSVLQQYEGKFSFTVEQESSDTVEAGLITRVSPDSGSSIAQGGFITIWVSTGKEKVAVPNITAGTDYVTAELMLKAVGLKAQANGPTGSTAVVVSINPGAGSQVDAGSTVTITTKAGSTGGGTGTGDGGNGTGNGGGTGE
What are the official names of this protein?
Probable serine/threonine-protein kinase PknB.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: SCPB_CLOPE
Sequence: MSDINQIEFSEISKKDELKSIIESLLFVSGEPLALKDICRIVEEDFKYVEDLMRELMNIYNGDSSRGIKIISLNGTYQLVTKTKNSEYVQKLLKKNVRQSLSQASLESLAIICYKQPITRVEIDEIRGVKSESAIQRLVEKNLVEETGRLEVPGRPILYGTTDEFLRHFALNDLGDLPSIELFEENDEVSDMVEE
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: ADRB_PENRW
Sequence: MQGWIVRISHWNTYLPIAGTMQACGDKSSVWKVAIGYNGHPEEATFFNGRRSYAVNNRGAKPEKERTLRLNIEITPVESQGCNQLPTPATFEFRIPHSHFFNWSVELYFHNAVLPSYRCHFCPRPSLVLRTHAISAEYSWLAVDITLGLNRHHNIAVEYVKYIKHLEVGKDIICQLLYLSGYFLYVVPLSIPTKYSKYVSQCTVDPYREAGGF
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of andrastins, meroterpenoid compounds that exhibit inhibitory activity against ras farnesyltransferase, suggesting that they could be promising leads for antitumor agents (Ref. 2).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase adrD via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Ref. 2).  DMAO is then converted to farnesyl-DMAO by the prenyltransferase adrG (Ref. 2).  The methyltransferase adrK catalyzes the methylation of the carboxyl group of farnesyl-DMAO to farnesyl-DMAO methyl ester which is further converted to epoxyfarnesyl-DMAO methyl ester by the FAD-dependent monooxygenase adrH (Ref. 2).  The terpene cyclase adrI then catalyzes the carbon skeletal rearrangement to generate the andrastin E, the first compound in the pathway having the andrastin scaffold, with the tetracyclic ring system (Ref. 2).  The post-cyclization tailoring enzymes adrF, adrE, adrJ, and adrA, are involved in the conversion of andrastin E into andrastin A.  The short chain dehydrogenase adrF is responsible for the oxidation of the C-3 a hydroxyl group of andrastin E to yield the corresponding ketone, andrastin D.  The ketoreductase adrE stereoselectively reduces the carbonyl moiety to reverse the stereochemistry of the C-3 position to yield andrastin F.  The acetyltransferase adrJ is the acetyltransferase that attaches the acetyl group to the C-3 hydroxyl group of andrastin F to yield andrastin C.  Finally, the cytochrome P450 monooxygenase adrA catalyzes two sequential oxidation reactions of the C-23 methyl group, to generate the corresponding alcohol andrastin B, and aldehyde andrastin A (Ref. 2).
What are the official names of this protein?
Andrastin A biosynthesis cluster protein B.
Protein: ECHD2_HUMAN
Sequence: MLRVLCLLRPWRPLRARGCASDGAAGGSEIQVRALAGPDQGITEILMNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGVFVQRLRGLMNDIAAFPAPTIAAMDGFALGGGLELALACDLRVAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNHAVAQNEEGDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRTPKFVGK
What are the official names of this protein?
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ADAD_ASPNC
Sequence: MSSVTLTTTTTTTSTPPKPTPKDEPQEQIYTPWRLFIYDIWVLGIVSTLAWGCRISTYLIPLFRSNVGKKHLDIGAGTGYYLNQARIPSTTQLTIVDNETHALNVALARCKHPSTQTHGIVTDILQPSPFPETYLTNNDKKFDSVSMYYLLHCLPVPVASKCKIFTHLKKYMTEDGVVHGANVLGKGVRKDNWFARIIRRGCLNHGVFHNEEDNAYEFERALRENFWEVETWVVGSVFVFRAKRPILDA
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist (PubMed:21866960).  The decaketide backbone of TAN-1612 is synthesized by the non-reducing polyketide synthase adaA via condensation of one acetyl-CoA starter unit with 9 malonyl-CoA units.  The FAD-dependent monooxygenase adaC then performs hydroxylation at C2 while the polaketide chain is still attached to the NRPKS adaA (PubMed:21866960).  The alpha-hydroxylation step at C2 appears to be crucial for the following C18-C1 Claisen cyclization and release of the C9-hydroxyl version of TAN-1612 from the NRPKS adaA, two steps performed by the lactamase-like protein adaB (PubMed:21866960).  Finally, the O-methyltransferase adaD performs the C9 O-methylation to complete the biosynthesis of TAN-1612 (PubMed:21866960).
What are the official names of this protein?
O-methyltransferase adaD, 2-acetyl-2-decarboxamidoanthrotainin biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: PAG76_BISBI
Sequence: RGSNLTIHPLRNIRDIFYVGNITIG
What are the official names of this protein?
Pregnancy-associated glycoprotein 76, AmbPAG 76 kDa.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: DAPB_CHLPM
Sequence: MKFTLVGNGRMGHEVASVIDASTVHSIAAVLDIDAVITPEVFRGSDAIIDFTVRDAFLENLDAMLASGVPVVTGTTGWDGLREEVAVKVSEAGASLLYSANFSLGVNVFLRTLREASRLIAPFAQFDIAMEEHHHTGKVDFPSGTALAAANVILSANSRKQRIVRELPEAGRLAPDDLQVASVRLGSVFGKHSAFIDSEADEIVLSHTAKSRSGFASGAVEAAVWLAGRHPKQPGMYSMDDFLNELLG
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_AGRVS
Sequence: MTAGIDLNDIKRRMDGAINAFKSDLASLRTGRASANILDPVMVEAYGSRVALNTVANITVPEPRMLGVSIWDKSMVGAVDRAIRESNLGLNPIVDGQNLRIPLPELNEERRKSLVKVAHGYAENSKVAIRHVRRDGMDSLKKAEKDGEIGKDDARSLSEKLQKMTDDTISDIDRLLAEKEKEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.