PharMolix/UniProtQA huggingface dataset:
Protein: HPR_BACCQ
Sequence: MKSGEKDYSVKEAMIFSQRIAQLSKALWKCVEKDWQMWIKPYDLNINEHHILTIAYHLKGASISEIAKFGVMHVSTAFNFSKKLEERGYLVFSKKEDDKRNTYIEITDKGEELLLRLMEEYDPENNSVFNGALALRNFYGKFPENIELIAILRNIYGQDFIDIFEKSLEDIEENFTESDQKLVKK
What is the function of this protein?
Negative regulator of protease production and sporulation.
What are the official names of this protein?
HTH-type transcriptional regulator Hpr, Protease production regulatory protein Hpr.
Protein: HIS3_PSEAB
Sequence: MKDWLDEIHWNADGLVPAIAQDHETGRVLMMAWMNREALALTASENRAIYWSRSRGKLWRKGEESGHVQKLHELRLDCDADVVILMVEQVGGIACHTGRESCFYRVFENGAWKTIDPVLKDPDAIYEHAGHHHE
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBM22_RAT
Sequence: MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYTQNMEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRTVTVVQRQQCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNVKWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGALPPPPAAEEEASANYFNLPPSGPPAVVNIALPPPPGIAPPPPPGFGPHLFHPMGPPPPFMRAPGPIHYPSQDPQRMGAHAGKHSSP
What is the function of this protein?
Required for pre-mRNA splicing as component of the activated spliceosome.  Involved in the first step of pre-mRNA splicing.  Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.  Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.
What are the official names of this protein?
Pre-mRNA-splicing factor RBM22, RNA-binding motif protein 22.
What is the protein family that this protein belongs to?
Belongs to the SLT11 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nearly exclusively nuclear. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.
Protein: SYT2_HUMAN
Sequence: MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK
What is the function of this protein?
Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity).  May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity).  Plays a role in dendrite formation by melanocytes (PubMed:23999003).
What are the official names of this protein?
Synaptotagmin-2, Synaptotagmin II, SytII.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein.
Protein: NOC41_XENLA
Sequence: MAARKTKHACRIQDKRSDAERQDLDTKLAAVLESRGNANAVFDILEHLESKKEEVVQAAIRTASKLFEVMLEKRELYIGDLPAENGTLPDTYSAEDKYKMWMRHRYNSCAACILDLLQHSSFSNQELALCTLMKFIQLEGKFPLENSEWKDSYRFPRELLKFVIDNLLQEEADCTLLITRFQEYLEYDDVRYYTMTVTNDCVSRVQQKNKLVLPPVFQTNVFCLLSSINIPVEESALGNFLVTKNVNNEDWKPSKLKDHKRVFERVWMIFLKHQLSVSLYKKVLLILHESILPHMSKPTLMIDFLTAAYDVGGAISLLALNGLFILIHQHNLEYPDFYKKLYSLLEPSIFHVKYRARFFHLANMFLSSTHLPVYLVAAFAKRLARLALTAPPQVLLMIIPFICNLIRRHPACRVLIHRPSAGDLATDPYIMEEQDPAKSQALESSLWELEVLQQHYHGDVVRAANVISRPLSAQESDISGLLEISSCELYDKEMKKKKFKSVPLEYEPVRGLLGLKSDITAQHFTF
What are the official names of this protein?
Nucleolar complex protein 4 homolog A, NOC4 protein homolog A, NOC4-like protein A, Nucleolar complex-associated protein 4-like protein A.
What is the protein family that this protein belongs to?
Belongs to the CBF/MAK21 family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus.
Protein: TSACC_MOUSE
Sequence: MEQHTSNPTKEKAKEEDSVACFCPAKSSPSYIDLPANFTPANFLTIQTKLSSGAGQKPKGCLGVLECMYANLQLQTQLAQRQIAILENLQASLSQPGSGRESKNCSLPGLCCKLLLNHLPQFHK
What is the function of this protein?
Co-chaperone that facilitates HSP-mediated activation of TSSK6.
What are the official names of this protein?
TSSK6-activating co-chaperone protein.
What is the protein family that this protein belongs to?
Belongs to the TSACC family.
Protein: KCY_STRA1
Sequence: MNSINIAIDGPASSGKSTVAKIIAKNLNYTYLDTGAMYRCATYLALQHGYEAQDVSKILGLLAERPISFGKAEDGSQTVFLGTEEVTLAIRQNDVTNNVSWVSAIPEIREELVNQQRRIAKDGAIIMDGRDIGTVVLPDAELKIFLVASVDERAERRFKENQEKGIESDFETLKSEIAARDYKDSHREVSPLEAAEDAIEFDTTGVSIEGVVTFIQEKAEKIIDMKN
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_PSEPG
Sequence: MIKVGIVGGTGYTGVELLRLLAQHPQAEVAVITSRSEAGVAVADMYPNLRGHYDGLAFSVPDSKALAACDVVFFATPHGVAHALAGELLAAGTKVIDLSADFRLQDAAEWGKWYGQPHGAPELLKDAVYGLPEVNREKIRQARLIAVPGCYPTATQLGFLPLLEAGLADPSRLIADCKSGVSGAGRGAAVGSLFCEAGESMKAYAVKGHRHLPEISQGLRLAAGKDIGLTFVPHLTPMIRGIHATLYANVVDTSVDLQALFEKRYADEPFVDVMPAGSHPETRSVRGANVCRIAVHRPQGGDLVVVLSVIDNLVKGASGQAVQNLNILFGLDERMGLSHAGLLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPEB1_DANRE
Sequence: MAFSLRENPRLLNCLDSDIPALSTCSNADAFCRMNTMLGNSLDLSGVCTTPTAKCKRDPFNDRPDSDLSAVRSRMLFPSGGQDSSRGLPDVNNWGLGLQSLSLSDWERPWSSHDTDPSVKTNTASLQGILGTPSQLTNKLSNYSDSSIGATDFLEKFPGMARLNSQSFLDSHSISPVDSETSGFSSGSDHLSDLLSSLRISPSVPFLMSSMQRDPLKLALDSRMDHSSSPLTPPPSASPSGSLSHRWPGASIWPSWDLMKTPESPFSIEREAWLHRQAASINEATFTWSGQLPPRHYQNPVYSCKVFLGGVPWDITEAGLINTFKCYGPLSVEWPGKDGKHPRCPPKGNMPKGYVYLVFESDKSVRALLQDCTEDLLHPEGYSEYYFKMSSRRMRCKDAQVIPWVISDSNYVSCPSQRLDPRNTVFVGALHGMLNAEALASIMNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVSAAFVEIKTPKFTKKVQIDPYLEDAICQSCSREPGPFFCRDKTCFKYYCRSCWHRQHSMDILSNHRPLMRNQKKRDAN
What is the function of this protein?
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early development.  Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (By similarity).
What are the official names of this protein?
Cytoplasmic polyadenylation element-binding protein 1, CPE-BP1, CPE-binding protein 1, CPEB-1, Orb/CPEB-related RNA-binding protein, Protein Zorba, ZOR-1, Zebrafish orb-type a.
What is the protein family that this protein belongs to?
Belongs to the RRM CPEB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Microtubule-associated.
Protein: RL4_ECOSM
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: CH602_SPHAL
Sequence: MAAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELADKFENMGAQMLREVASKQNDKAGDGTTTATVLAQAIVREGSKAVAAGMNPMDVKRGIDLAVKAVVKDLETHAKKVSANSEIAQVATISANGDEEVGRILAEAMDKVGNEGVITVEEAKSLATELETVEGMQFDRGYLSPYFITNAEKLKVELDDPYILIHEKKLSNLQAMLPLLEAVVQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGNVVSEDLGIKLENVTVNMLGRAKKVVIDKDNTTIVDGVGARTDIDARIAQIRQQIDTTTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDALHATRAAVEEGILPGGGIALLRALKALDGLKAANDDQQSGIDIVRRALRAPARQIADNAGEDGAWIVGKLLESSDYNWGFNAATGEYEDLVKAGVIDPAKVVRTALQDAASVAALLITTEALVAELPKEEKAAPMPAMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPL8_ARALL
Sequence: MDKTDQTAIDGSALELNRTEKTVEAVLRVASMALSITGLVIMIKNSISNDFGSLSYSNLGAFMYLVGANGVCAAYSLLSALAILALPCPISKVQVRTLFLLDQVVTYVVLAAGAVSAETVYLAYYGNIPITWSSACDSYGIFCHKALISVVFTFVVSLLYMLLSLISSYRLFSRFEAP
What are the official names of this protein?
CASP-like protein 2A2, AlCASPL2A2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PKNB_LACLA
Sequence: MIQIGKIFADRYRIIKEIGRGGMANVYQGEDTFLGDRLVAIKVLRSNFENDDIAIARFQREAFAMAELSHPNIVGISDVGEFESQQYIVMEFVDGMTLKQYINQNAPLANDEAIEIITEILSAMDMAHSHGIIHRDLKPQNVLVSSSGTVKVTDFGIAKALSETSLTQTNTMFGSVHYLSPEQARGSNATVQSDIYAIGIILFELLTGQIPFDGDSAVAIALKHFQESIPSIINLNPEVPQALENVVIKATAKDIKNRYTDVEEMMTDVATSTSLDRRGEEKLVFNKDHDETKIMPANLINPYDTKPLIDKKEDNDSQTDEKAASSEVGNKNKKSKKGLIIGLIILLLVVGGATLAWVVSTPTNVKIPNVTNSTLSQAKSKIKDAKLKVGTVHKQQSSTIAEGKVIKTDPTSGTTVRSNSSVDIYVSTGNEDIIKMKDFVGEKIDEAMATLLKDYGIDESQVTQTSVPSDSYPAGTIIKQSPKKGSSFDTKGSEKITFEVSSGKQVEVPDYKPNGQYMTYSQYQAALKAAGFTNITLDPQATTNQQADGYVYSVYPNVGTSVDPTQEIVVTYSVYTAPSSSSTTSESTTTSETSSSTTSSTSSSTTSQPSTDNNNSSKESSTTSSSS
What are the official names of this protein?
Probable serine/threonine-protein kinase PknB.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: MATRX_VSNJO
Sequence: MSSFKKILGLSSKSHKKSKKMGLPPPYDESCPMETQPSAPLSNDFFGMEDMDLYDKDSLRYEKFRFMLKMTVRSNKPFRSYDDVTAAVSQWDNSYIGMVGKRPFYKIIAVIGSSHLQATPAVLADLNQPEYYATLTGRCFLPHRLGLIPPMFNVQETFRKPFNIGLYKGTLDFTFTVSDDESNEKVPHVWDYMNPKYQSQIQQEGLKFGLILSKKATGTWVLDQLSPFK
What is the function of this protein?
Plays a major role in assembly and budding of virion.  Condensates the ribonucleocapsid core during virus assembly.  Shut off cellular transcription by inhibiting mRNA nuclear export through direct interaction with host RAE1-NUP98 complex.  This shutoff presumably inhibits interferon signaling and thus establishment of antiviral state in virus infected cells.  Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell (By similarity).
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the vesiculoviruses matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein. Host nucleus membrane; Peripheral membrane protein.
Protein: LLDD_HAEIN
Sequence: MIISSASDYREAARRRVPPFMFHYADGGSYAEQTLARNVSDLENIALRQRVLKDMSELDTSIELFGEKLSMPTILAPVGACGMYARRGEVQAAQAADNKGVPFTLSTVSICPIEEVAPAIKRPMWFQLYVLKDRGFMKNALERAKAAGCSTLVFTVDMPTPGARYRDMHSGMSGPYKEIRRVLQGFTHPFWAYDVGIKGKPHTLGNVSTYMGRQIGLDDYIGWLTENFDPSISWKDLEWIREFWEGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSSARALPPIADAVKGDIKIIADSGIRNGLDIVRMLALGADATMLGRAFVYALGAEGRQGVENMLDIFKKEMHVAMTLTSNRTIADIKPEALVDLSKL
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: OPGH_SHEPC
Sequence: MTVSENSVLETEVLVGGSAMPNERPGAMEPQSLTEMPEGFPRRSTVANGVRSRSSRRFFVVGGALLLSSFAIYEMGAVFSIGGITPLEYLVLLLFAINFCWIALAFCSGIAGFLILLRKPKAKDLEVTELHTRTAILMPTYNESPDRVFSAVSVMAEALSQTGHGHAFDWFILSDTTDPEIALLEEQAFLVLRQETHKHSRVYYRRRRKNVARKAGNVADFCRRWGSRYDHLLVLDADSLMESSTITGLAQRMQADPDAGLIQTIPSLINGTTLMARLQQFAARIYGPVIGTGLGWWVQKEGNFWGHNAIIRTEAFMGAAGLPNLKGKPPFGGHILSHDFVEAALIRRAGWSVVIAYDLPGSYEECPPSIVDLAVRDRRWCQGNLQHSRILPTKGLHWVSRLHLLTGIMAYLSSPFWLLLILTGLMLALQAHFIRPEYFTDQFSLFPTWPIMDSDRALRLFYITMGVLFGPKIFGVLLLLKDGQFARSVGGRIKAIFSVLFEVVLSALIAPIMMFIHCGAVMSILMGRDSGWSPQRRDDGSMPWLTLIYRHRWHMLAGVMLGYAAILDSLTLLAWMSPALIGLWFAVPISAWTGSVKIGEVFKRAGILATPEERSPAAICLQAQDARAAYQAHISKPWTLAQLLKDPALMELHLAMVDKQPLRAAGTPIEPVEAIVHVKVHEAQCQESAMALFNRQEMALVLANPLMLRSLQKLPEQFVAEDLVSFC
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis glucosyltransferase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. OpgH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPP2B_RAT
Sequence: MAAARLAASLLLLAAQVACEFGVLRVVPQSGGTRGRDYCILYNPQWAHLPHDLNKVSLLKLRDLSTTQLCSHLDVPVEDFTNQIALVARGNCTFYEKVRLAQGSGAHGLLIVSKERLVPPRGNKTQYEEISIPVALLSHRDLQDIFRRFGHEVMVALYAPSEPVMDYNMVIIFIMAVGTVALGGYWAGSHDVKKYMKHKRDDVPEKQEDEAVDVTPVMICVFVVMCCFMLVLLYYFYDRLVYVIIGIFCLASSTGLYSCLAPCVRKLPFCTCRVPDNNLPYFHKRPQARMLLLALFCVTVSVVWGVFRNEDQWAWVLQDTLGIAFCLYMLRTIRLPTFKACTLLLLVLFVYDIFFVFITPYLTKSGNSIMVEVATGPSNSSTHEKLPMVLKVPRLNTSPLSLCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRIYFVACTIAYGLGLLVTFVALVLMRHGQPALLYLVPCTLLTSCTVALWRREMGAFWTGSGFADAPQTPWAAPQGPVPPKDVDASLSEQPRGEELAQSPLATEEAGATDPAKDPDSPVAGPLSPSNGDQVQPIPVVTPGTSA
What is the function of this protein?
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.  Functions in ITM2B and TNF processing.  Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus.  May play a role in the regulation of innate and adaptive immunity.
What are the official names of this protein?
Signal peptide peptidase-like 2B, SPP-like 2B, SPPL2b.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side. Note=targeted through the entire secretory pathway to endosomes/lysosomes.
Protein: EFG_ENDTX
Sequence: MAREYPLNKVRNFGIAAHIDAGKTTTTERILYYTGRTHKIGEVHEGAATMDWMEQEKERGITITSAATYCRWQDMQFNIIDTPGHVDFTAEVERSLRVLDGAVVVFDSGNGVEPQSETVWRQADKYGVPRIVFSNKMDKVGADFFMVVNDIEEKLGAKPIPVQIPIGAESSFQGIVDLVTMKAHIWSGEELGAKFDITDVPKELEEKAHAARSEMIELIADYSDDIMNNFMEGKESTAVQIKQAIRNATLQIKLIPVLCGTAFKNKGVQPMLDAVCDYLPSPLDRKAFKGINPVTSETDSREVDDKAPFSALAFKIQADPYIGKLTYLRVYSGTLESGSYVYNPIKDAKERISRIVRMHSNNREEVKSVNTGDIAAAVGLKNTGTGDTLCDEEKPILLESMDFPVPVIDVAIEPKSKADEEKLGIALNRLSEEDPTFRVRTNEETNQTIIAGMGELHLEILVDRMKREFNVQANVGRPQVAYRETIRKVQEAESKYIRQTGGRGQYGHVVLTVEPQDPGKGYEFVNKIVGGVIPREYIPAIDKGIKEAMTSGTLAGYPVADVKVVVIDGSFHEVDSSEMAFKIAGSMAFKDACRKASPVILEPIMKTEVIVPEEYMGDVIGDLNSRRGKIVSMESKNKVQHIKANVPLAEMFGYSTTLRSLTQGRGNYSMEPSHYEEVPSQIADKILERTTRG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_PARL1
Sequence: MKASDVRDMTPDQLQDELLKLKKTQFNLRFQGASGQLEKVHQMRQVRRDIARIKTIQRQRSAETASKS
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: CK2N2_XENLA
Sequence: MSEILPYSDEKMGHYGSDGEVGQISFSCRLQDTSSFFGGNQQKRPPKLGQIGRAKRVVIEDDRIDEVLKGVSDKSPSGV
What is the function of this protein?
Potent and specific cellular inhibitor of CaM-kinase II (CAMK2).  Traps Ca(2+)/calmodulin on CAMK2 (By similarity).
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase II inhibitor 2.
What is the protein family that this protein belongs to?
Belongs to the CAMK2N family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: SHUT_ADE05
Sequence: MESVEKKDSLTAPSEFATTASTDAANAPTTFPVEAPPLEEEEVIIEQDPGFVSEDDEDRSVPTEDKKQDQDNAEANEEQVGRGDERHGDYLDVGDDVLLKHLQRQCAIICDALQERSDVPLAIADVSLAYERHLFSPRVPPKRQENGTCEPNPRLNFYPVFAVPEVLATYHIFFQNCKIPLSCRANRSRADKQLALRQGAVIPDIASLNEVPKIFEGLGRDEKRAANALQQENSENESHSGVLVELEGDNARLAVLKRSIEVTHFAYPALNLPPKVMSTVMSELIVRRAQPLERDANLQEQTEEGLPAVGDEQLARWLQTREPADLEERRKLMMAAVLVTVELECMQRFFADPEMQRKLEETLHYTFRQGYVRQACKISNVELCNLVSYLGILHENRLGQNVLHSTLKGEARRDYVRDCVYLFLCYTWQTAMGVWQQCLEECNLKELQKLLKQNLKDLWTAFNERSVAAHLADIIFPERLLKTLQQGLPDFTSQSMLQNFRNFILERSGILPATCCALPSDFVPIKYRECPPPLWGHCYLLQLANYLAYHSDIMEDVSGDGLLECHCRCNLCTPHRSLVCNSQLLNESQIIGTFELQGPSPDEKSAAPGLKLTPGLWTSAYLRKFVPEDYHAHEIRFYEDQSRPPNAELTACVITQGHILGQLQAINKARQEFLLRKGRGVYLDPQSGEELNPIPPPPQPYQQQPRALASQDGTQKEAAAAAATHGRGGILGQSGRGGFGRGGGGHDGRLGEPRRGSFRGRRGVRRNTVTLGRIPLAGAPEIGNRFQHGYNLRSSGAAGTARSPTQP
What is the function of this protein?
Protein that inhibits host translation while promoting late viral translation by ribosome shunting.  Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation.  Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell.  During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers.
What are the official names of this protein?
Shutoff protein, 100 kDa protein, p100K, 100K-chaperone protein, L4-100K, Shutoff protein 100K.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae shutoff protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: 1104L_ASFM2
Sequence: MLVIFLGILGLLANQVLGLPIQAGGHLCSTDNPPQEELGYWCTYMESCKFCWECAHGICKNKVNESMPLIIENSYLTSCEVSRWYNQCTYGEGNGHYHVMDCSNPVPHNRPHQLRMKIYEKEDL
What is the function of this protein?
Causes the redistribution of lumenal ER protein to an enlarged ERGIC compartment.
What are the official names of this protein?
Protein MGF 110-4L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 110 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment.
Protein: Y258_DICTD
Sequence: MKNPFEAMKQLKKLQEKMAKIEEELEQTLVEGTAGGGVVKIVMTAKEEVKEVKIDPEVVNKDEVDILEDLIAAALRDALTKAKEKSAEKMGSLTDGLPLPPGLF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Dtur_0258.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PA_I02A3
Sequence: YGEDPKVETNKFAAICTHLEVCFMYSDFHFIDERNESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYILDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEINGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLLAWKQVLAEIQDIENEEKIPKTKNMKKTGQLKWALGENMAPEKVDFEDCKDVSDLRQYNSDEPESRSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFESKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRRLLLIVQALGDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: LOLA_SHEFN
Sequence: MNKRITVLSLLLATSLSSAAAMADDATELRAKLSNIDSLHATFSQQVTDINSKPIQTGSGVFALAYPNQFYWHLTQPDESLIVADGANLWIYNPFAEEVTVMDVAQAVDASPMALLVHRDEATWAKYSVTKRAVSGKSTCFDIQPKKLNSNVVAVSVCFEASQLVKFNLTDEQGNLSQFALTQQRKVKDNEANIFKFAVPDNVDIDDQRLKQAN
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PDXJ_NITEC
Sequence: MIALGVNIDHVATLRQARGTDYPSPIKAALVAEESGADAITLHLREDRRHIQEEDVIILRERLKTRMNLESAVTEEMISFACRIKPHDICLVPERREELTTEGGLDVIRHFDQVSAACKRLTEAGIRVSLFVDARADQIDAAIRVGAPVIELHTGHYADAATSEAQQAELETIRSMAAYAFSRGLQVNAGHSLHYQNTTPIAFIPEITELNIGHAIVARALFIGFAQAVREMKTLMQEARA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.