PharMolix/UniProtQA huggingface dataset:
Protein: EMC6_XENLA
Sequence: MAGVALKREGPQFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTSLYGFIFYFLASFLLSLLLVLKSGRKWNKYFKSRKPLFTGGLVGGLFTYVLFWTFLYGMVHVY
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
What are the official names of this protein?
ER membrane protein complex subunit 6, Transmembrane protein 93.
What is the protein family that this protein belongs to?
Belongs to the EMC6 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GPX4_SOLLC
Sequence: MATQTSNPQSVYDFTVKDAKGKDVDLSIYKGKVLIIVNVASQCGLTNSNYTDMTELYKKYKDQGLEILAFPCNQFGGQEPGNIEDIQQMVCTRFKAEYPIFDKVDVNGDNAAPLYRFLKSSKGGFFGDGIKWNFSKFLIDKEGHVVDRYSPTTSPASMEKDIKKLLGVA
What is the function of this protein?
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
What are the official names of this protein?
Probable phospholipid hydroperoxide glutathione peroxidase, PHGPx.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARHL1_PONAB
Sequence: MEKFKAAMLLGSVGDALGYRNVCKENSTVGMKIQEELQRSGGLDHLVLSPGEWPVSDNTIMHIATAEALTTDYWCLDDLYREMVRCYVEIVEKLPERRPDPATIEGCAQLKPNNYLLAWHTPFNEKGSGFGAATKAMCIGLRYWKPERLETLIEVSVECGRMTHNHPTGFLGSLCTALFVSFAAQGKPLVQWGRDMLRAVPLAEEYCKKTIRHTAEYQEHWFYFEAKWQFYLEERKISKDSENKAIFPDNYDAEEREKTYRKWSSEGRGGRRGHDAPMIAYDALLAAGNSWTELCHRAMFHGGESAATGTIAGCLFGLLYGLDLVPKGLHQDLEDKEKLEDLGAALYCLSTEEK
What is the function of this protein?
Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity).  Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity).
What are the official names of this protein?
Inactive ADP-ribosyltransferase ARH2, ADP-ribosylhydrolase-like protein 1, [Protein ADP-ribosylarginine] hydrolase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the ADP-ribosylglycohydrolase family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere.
Protein: ENGB_STRS7
Sequence: MSEEQILNTHNASILLSAANKSHYPQDDLPEIALAGRSNVGKSSFINTILGRKSLARTSSKPGKTQLLNFFNVDDKLRLVDVPGYGYAKVSKAERARWGKMIEEYLTTRQNLRAVVSLVDFRHEPSQDDIQMYEFLKYYEIPVIIVATKADKVPRGRWNKHESMVKKSLNFDQTDAFIIFSSVERIGIDESWDTILEYL
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: FRO7_ARATH
Sequence: MDDHETPLLSKDLSSSSSSSSSSSSVVVSSLKWILKVVMSVIFVTWVVFLMMYPGSLGDQILTNWRAISSNTLFGLTGSMFLIFSGPILVIAILASLYLIISGEETVFTKKKITKFPRFRLWTFPVLVDGPFGVVSAAEFLGIMVFSVFFLWAIYAYTLRNLNVLDYFHVLPNNRSIFLLELTGLRFGMIGLLCMVFLFLPISRGSILLRLIDIPFEHATRYHVWLGHITMTFFSLHGLCYVVGWTIQGQLLELLFEWKATGIAVLPGVISLVAGLLMWVTSLHTVRKNYFELFFYTHQLYIVFVVFLALHVGDYLFSIVAGGIFLFILDRFLRFYQSRRTVDVISAKSLPCGTLELVLSKPPNMRYNALSFIFLQVKELSWLQWHPFSVSSSPLDGNHHVAVLIKVLGGWTAKLRDQLSTLYEAENQDQLISPESYPKITTCVEGPYGHESPYHLAYENLVLVAGGIGITPFFAILSDILHRKRDGKDCLPGKVLVVWAIKNSDELSLLSAIDIPSICHFFSKKLNLEIHIYVTRQSEPCLEDGMVHKVVHPSVKTPWTNGCSMSVLVGTGDNIWSGLYLIISTIGFIAMITLVDIFYINKYNITTWWYKGLLFVVCMVASVLIFGGLVVVFWHRWEHKTGEVEANGNDKVDLNGEETHNPSAAELKGLAIEEDVQNYTTIRYGTRPAFREIFESLNGKWGSVDVGVIVCGPATLQTTVAKEIRSHSIWRSANHPLFHFNSHSFDL
What is the function of this protein?
Ferric chelate reductase involved in iron mobilization from the cytosol into the chloroplast.  May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates.  Might be involved iron homeostasis in trichomes.
What are the official names of this protein?
Ferric reduction oxidase 7, chloroplastic, AtFRO7, Ferric-chelate reductase 7.
What is the protein family that this protein belongs to?
Belongs to the ferric reductase (FRE) family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: ATFS1_CAEEL
Sequence: MFSRVGRLTTFGAQAVSNCPFRRDNIYQQPLKVTAPINDQLTSFAHSFSDSVRHRTTSFGNDPFLGVPMDDDEVIKELELLDLDSWHTKPRAPCPAPSDELELDQFWEGKNVTVCGRDPRLGKSTDCFELEAWRPTDSWQNGSSVGHPHGHQQQQQTCQQPPTHSSTTETMHDFSNFGDNMGSPLFQSPSKSAIDQLTGTSRIDEYGMPPQDRKLSKFEMDIEQESKAVDWEAWNHYLESDDDVFKRPEAFFKEEPMIMTSSDSLMTSSTSSPDSGISLYDPMIPPPSSHFPSFNLSSSSSASNLLRLSTPSAPMQQEHRAPVRMHHDVDLFSSGPLLCVPKQEDVFDDFIQQRDDDDEDYIPASEARRTSSRLNRKSATPTYLRRRDSERSWTPASDDYFPEEHQKFKKRGVVLKPSVDEETDRRRMLNRIAAVRYREKKRAEKKGRKMEFQEVADRNRILLQKERQLKREINSMKKELRKMGAIIQ
What is the function of this protein?
Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR) (PubMed:22700657, PubMed:25274306, PubMed:25773600, PubMed:30642431).  Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity (PubMed:22700657, PubMed:25274306, PubMed:25773600).  Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of chaperone and assembly factor genes (PubMed:25773600).  Component of a feedback loop involving atfs-1, atgl-1 and hlh-11 (PubMed:33078707).  Acts together with flp-7 to negatively regulate the expression of the transcription regulator hlh-11, to promote expression of atgl-1, and thus atgl-1-dependent fat oxidation in response to mitochondrial stress (PubMed:33078707).  In addition, functions with hlh-11 to maintain lifespan (PubMed:33078707).  Promotes mtDNA maintenance and propagation of deleterious mtDNA (PubMed:27135930).
What are the official names of this protein?
Stress activated transcription factor atfs-1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Cytoplasm. Nucleus. Note=In absence of mitochondrial stress, localizes mainly to mitochondria where it is rapidly degraded by protease lonp-1 (PubMed:22700657). Upon mitochondrial stress which causes a reduction in protein mitochondrial import, accumulates in the cytoplasm and translocates into the nucleus to activate transcription of mitochondrial unfolded protein response genes (PubMed:22700657). Similarly, accumulates in the nucleus in response to P.aeruginosa- mediated infection (PubMed:25274306).
Protein: RPOC_MYCBT
Sequence: MLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRAPFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERKAVEDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGEREMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVIRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPASGDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPPVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITIVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQVKVRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRNIAVQPTEEARAAAYTIPSYEDQYYSPDFGAATGAAVPLDDYGYSDYR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RPIA_BAUCH
Sequence: MMHEKLKKAVGWAALEYVSSGMIIGVGTGSTTDHFIDALGTVKHKIEGVVSSSEQSTTKLKSMGILLFNLNDVDGLDIYVDGTDEINSNMQMIKGGGAALTREKVLAAAANKFICIADTSKQVDILGNFPLPIEVIPMAHAWVARELVHLTGGLPKYRQGVITDNGNIILDIYNLKILDAIALEKIINNIPGVVTVGLFANRCADIALISSDLGIEEISRSIK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: Y7754_DICDI
Sequence: MTSLISITLDELLINEDINDDYTCCVCECLLIEALQCRNGHVACKNCFIKIVKSKKECMTCRCEIKSIESLSKNRYLEKEIRKLNINCPNSFLKRELNLNNNNKNGNGNEGSSANEIEQPQQPQQQQPQELIKDINNGCKEILTIDQLDSHLKQCEYRFLKCTNLYANDLCSELDICGYDYRYNQSEKHRDECPYGIIGCTLCGKDCSRVDIESHTENHCPKLLVKCPTCNQDQLIARCDLDDHLSVDCAMIEIDCILKESGCKERVKRNQLANHLSSDNHLLFINNQFNQQNDIINQLKLELSHCNDLNEILTAKLDRYNNDNTMFRGKWVISNWTDKLNQYPPKKYLSLDFNLSQNKPFSIRVYPNGSSVMWHNCTISLVKLYQTESTIKFSFEIENEDPLKNDLQTKTDIFKGLNDSWSLQFFKVCDQANNNGFIINDTLTINFSIKIKKCFENIFITE
What is the function of this protein?
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
What are the official names of this protein?
TNF receptor-associated factor family protein DDB_G0267754.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_MYCGA
Sequence: MKVILLKDVPSLGKADSVVNVANGYAKNFLFKNKLAEPYTERGQKRLDLKVIKRNEQHDLLALEAKNLAKQLEGVVLEYDIRTNEEDKAFGTIGFKQIVDDLSKKHIFVTKDMLDSKMKLDIGEHRVKINIFEGIHATILVKVSKAQ
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RL31_RICBR
Sequence: MKNGIHPDYKKFLIKVGSDVFETMSTHPAGEILMDVDFRKHPAWNKDIGNVVNQSNKSISDFNKRFSGLSFGSQKKEAS
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RL15_SACD2
Sequence: MRLNTLSPAPGRVSAKKRVGRGIGSGLGKTAGRGHKGLKSRSGGSVKPGFEGGQMPLQKRLPKFGFTSRISRVTAEVRLAELNKVEADIIDIEALRAADLIDNNIKRAKVFLSGELTKAVTIKGLMVTKGAKAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PDIA1_BOVIN
Sequence: MLRRALLCLALTALFRAGAGAPDEEDHVLVLHKGNFDEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFKNGDTASPKEYTAGREADDIVNWLKKRTGPAASTLSDGAAAEALVESSEVAVIGFFKDMESDSAKQFFLAAEVIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYEGKLSNFKKAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESDELTAEKITEFCHRFLEGKIKPHLMSQELPDDWDKQPVKVLVGKNFEEVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDLEEDDDQKAVKDEL
What is the function of this protein?
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds.  At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell.  May therefore cause structural modifications of exofacial proteins.  Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins.  At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins.  At low concentrations, facilitates aggregation (anti-chaperone activity).  May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis.  Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.  Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
What are the official names of this protein?
Protein disulfide-isomerase, PDI, Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. Localizes near CD4-enriched regions on lymphoid cell surfaces. Colocalizes with MTTP in the endoplasmic reticulum.
Protein: RS7_DELAS
Sequence: MPRRREVPKREILPDPKFGNVELSKFMNVIMEGGKKAVAERIIYGALDLIQKKHPDKDPLEAFVVAINNVKPMVEVKSRRVGGANYQVPVEVRPVRRLALSMRWLKEAARKRGEKSMAQRLANELLEATEGRGGAMKRRDEVHRMAEANKAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ATP6_STAAR
Sequence: MDHKSPLVSWNLFGFDIVFNLSSILMILVTAFLVFLLAIICTRNLKKRPTGKQNFVEWIFDFVRGIIEGNMAWKKGGQFHFLAVTLILYIFIANMLGLPFSIVTKDHTLWWKSPTADATVTLTLSTTIILLTHFYGIKMRGTKQYLKGYVQPFWPLAIINVFEEFTSTLTLGLRLYGNIFAGEILLTLLAGLFFNEPAWGWIISIPGLIVWQAFSIFVGTIQAYIFIMLSMVYMSHKVADEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLGH_SHISS
Sequence: MQKNAAHTYAISSLLVLSLTGCAWIPSTPLVQGATSAQPVPGPTPVANGSIFQSAQPINYGYQPLFEDRRPRNIGDTLTIVLQENVSASKSSSANASRDGKTNFGFDTVPRYLQGLFGNARADVEASGGNTFNGKGGANASNTFSGTLTVTVDQVLVNGNLHVVGEKQIAINQGTEFIRFSGVVNPRTISGSNTVPSTQVADARIEYVGNGYINEAQNMGWLQRFFLNLSPM
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: S12A5_MOUSE
Sequence: MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANPRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGERETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS
What is the function of this protein?
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity).  As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity).  Involved in the regulation of dendritic spine formation and maturation (By similarity).
What are the official names of this protein?
Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, K-Cl cotransporter 2, mKCC2, Neuronal K-Cl cotransporter.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Cell projection, dendrite. Cell membrane; Multi-pass membrane protein. Note=Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses.
Protein: PROA_XANOM
Sequence: MTIKTLALQCRDAAQVVSQLSSQAKCALLQAMAAALEADAGTILAANARDLEAARAKGTASAMLDRLALDDKRLAGIAAALREVALLPDPVGRITREDVRPNGIRVQKVRVPLGVIAMIYEARPNVTADAAALCIKAGNGVILRGGSEAIHSNIAIARALQRALREANVPEAALTLVEDLRRETMLELLQLNDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASAEMELALRLLIDGKATRPSACNSLETLLVHADIAERFLPLAAQALRERKVELRGDAATRAVLPEIAPASDDDYAAEFLDLILAMRVVADLDTALAHIRQYGSDHTEVIATQDPDNAERFVQSLRSAVVMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALTVERFVVRGEGQVRH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP198_ARATH
Sequence: MRCSVSSVVRPLSVDPATAIATLCSKGNLREAFQRFRLNIFTNTSLFTPFIQSCTTRQSLPSGKQLHCLLVVSGFSSDKFICNHLMSMYSKLGDFPSAVAVYGRMRKKNYMSSNILINGYVRAGDLVNARKVFDEMPDRKLTTWNAMIAGLIQFEFNEEGLSLFREMHGLGFSPDEYTLGSVFSGSAGLRSVSIGQQIHGYTIKYGLELDLVVNSSLAHMYMRNGKLQDGEIVIRSMPVRNLVAWNTLIMGNAQNGCPETVLYLYKMMKISGCRPNKITFVTVLSSCSDLAIRGQGQQIHAEAIKIGASSVVAVVSSLISMYSKCGCLGDAAKAFSEREDEDEVMWSSMISAYGFHGQGDEAIELFNTMAEQTNMEINEVAFLNLLYACSHSGLKDKGLELFDMMVEKYGFKPGLKHYTCVVDLLGRAGCLDQAEAIIRSMPIKTDIVIWKTLLSACNIHKNAEMAQRVFKEILQIDPNDSACYVLLANVHASAKRWRDVSEVRKSMRDKNVKKEAGISWFEHKGEVHQFKMGDRSQSKSKEIYSYLKELTLEMKLKGYKPDTASVLHDMDEEEKESDLVQHSEKLAVAFALMILPEGAPIRIIKNLRVCSDCHVAFKYISVIKNREITLRDGSRFHHFINGKCSCGDYW
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g41080.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
Protein: UXUA_HAEIE
Sequence: MEQAWRWYGPKDPVSLSDIRQAGATGIVTALHHIPNGEIWRIEEIKKRKTEIENAGLSWSVVESVPVHEEIKTQTGNYQKWINNYKQTLRNLAQCGIDTVCYNFMPVLDWTRTDLAYELPDGSKALRFDHIAFAAFELHILKRPDAEKAYNQEEQVAARTYYDKMSAQDITQLTRNIIAGLPGAEEGYTLDEFQTQLDRYKDISSEKFRTHLAYFLNEIVPVAQEVGIKMAIHPDDPPRPILGLPRIVSTIEDMQWFVETQPLPANGFTMCTGSYGVRSDNDLVKMIEQFADRIYFAHLRSTQREDNPLTFHKAAHLEGDVDMFNVVKALLNEEYRRLNQGETRLIPMRPDHGHQMLDDLRKKTNPGYSAIGRLKGLAEFRGLEMALKKVYFNK
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: SYT_AZOPC
Sequence: MIKITFPNTSARNYAIGTTPMQIAESISCRLAEEILSANVNGEMWDLSRPINENASVKLYKWEDFEGKRTFWHSSAHLLAESLQELYPNIHFGMGPAIENGFYYDVDLGDGVVIKDVDLVTIEKKMQELASKKLSISRQNVTKQNALELFGKKGETYKIELISKLEDGKITVYTQGNFTDLCRGPHLPNTSYIKAIKLTSVARAYWKGDESRKQLTRIYGISFPKKEELSEYLALMEKAKKRDHRRIGKEMELFTFSHKVGRGLPLWLPKGTQLRLRLEDFLKRIQKKYGYQQVITPHIGNKTLYIASGHYAKYGKDSFQPIHTPELGEEFLLKPMNCPHHCEIYKAFLRSYKELPLRLAEFGTVYRYERSGELQGLTRVRGFTQDDAHIFCSPEQVKEELIKVIDIVRVIFCALNFNDYEVQISLRDLNNRIKYIGSEENWKNSEGAIIEVCQEKKIKAKIKLGEAAFYGPKLDFMVKDALGRNWQLGTIQVDYNLPERFELEYVGADNQKHRPVMIHRAPFGSMERFVAVMIEHTGGKFPLWLVSDQVVILPVSENYNQYAEEIAKEFHKRDIRVTIDKRNEKVGRKIRDNELKKIPYLLIIGEKERRNSEISVRKHGKENIGIMKVTEFAEFLKKEVERQMSQWQ
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_RICFE
Sequence: MNTKFPITAKGFEKLEHELKHLKHVERKKISEDIAEAREHGDLSENAEYEAAREKQAFIEGRIKELEDMTARAEIIDIGKLSGDNIKFGATVTLIDDDTEEEVTYIIVGEYEADITRKRVSIASPIAKALIGKSVGDFVEVTTPKGSKSYEVVTVEYKELEL
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.