PharMolix/UniProtQA huggingface dataset:
Protein: TBP_DICDI
Sequence: MSTATTTSTPAQNVDLSKHPSGIIPTLQNIVSTVNMATELDLKAIALGARNAEYNPKRFAAVIMRIREPKTTALIFKSGKMVCTGAKSEDASRFAARKYARIIQKLDFPARFTDFKIQNIVGSCDVKFPIKLELLHNAHTSFTNYEPEIFPGLIYKMIQPKVVLLIFVSGKIVLTGAKVREEIYEAFENIYPVLSAFKKVNAITQ
What is the function of this protein?
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID.  Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
What are the official names of this protein?
TATA-box-binding protein, TATA sequence-binding protein, TBP, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PONL_DICDI
Sequence: MKLTLLLIISFILFSNVVFSQKFNLFNFEQNHCLTTPELFLDECQLLNSTLPMCKGYMRVTYVSSNTYEFSIFNTSTPLCGQVNRKAGSNFTCDQSTNGVKQNYTGFSVTCISTSNESSLSSKTQQSIVFTVLLLSLALIASIF
What is the function of this protein?
Binds F-actin and nucleates actin assembly.
What are the official names of this protein?
Ponticulin-like protein L.
What is the protein family that this protein belongs to?
Belongs to the ponticulin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: MUG_ECO57
Sequence: MVEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDHQLKPQEAQHLLDYRCGVTKLVDRPTVQANEISKQELHAGGRKLIEKIEDYQPQALAILGKQAYEQGFSQRGAQWGKQTLSIGSTQIWVLPNPSGLSRVSLEKLVEAYRELDQALVVRGR
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_PSEA7
Sequence: MNTLLMHCRPGFEGEVCAEIAEHAATLEIPGYARSKPASAHVEFVCQDVDGAERLMRRLRFAELIFPRQWARGPGFIELPESQRIEVLLEELASYPVCGSLWLEVLDTNAGKEVSTFCRKFEKPLRAALVKAGRLQEDLALPRLLLTFRSGREVFVGLAEPRNSALWPMGIPRLKFPREAPSRSTLKLEEAWHQFIPRQEWDKRLAPDMLAVDLGAAPGGWTWQLVNREMRVTAVDNGPMAENLMYSGLVDHQKVDGYQYRPRQRVDWMVCDIVEKPARTGALIETWIGEGLCREAVVNLKLPMKQRYAEVRKILQRLRESFDARGLKVAFGCKQLYHDREEVTCHLRRLER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISR1_YEAST
Sequence: MNSTPPTSPVTRVSDGSFPSISNNSKGFAYRQPQKHKSNFAYSHLVSPVEEPTAKFSEAFQTDYSSKAPVATSEAHLKNDLDVLFTTPRFYSPENLALMFRLSNTVSSLEFLDEFLMGILLAPEMDFLSNPSYSLPSNKLVGQGSYSYVYPISSSASSRCNNDSGVVLKFAKSQHKSKVILQEALTLAYLQYMSPSTNESHIIPFYGLTYITKSHFRRLRSNECVPGLILPKCEMSLYHFNTAVSHKLSLITKRKIWWRLMKQMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQTPTDLNTTVEYCAPELIDSSSDHVPTFESDLYAVGLCLLSFISQHEPYNELQALVSHGSSPGIGSSSIQQSQWLINALLKKDPINLNMLRNDLFQDWKSELALLSRILVDRLPLENLITILDSNYI
What is the function of this protein?
Probable serine/threonine protein kinase which may function redundantly with MPK1-independent branch of the PCK1 pathway that is presumed to be required for the tolerance to high temperatures and staurosporine.
What are the official names of this protein?
Serine/threonine-protein kinase ISR1, Inhibition of staurosporine resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: EX7L_SALG2
Sequence: MLSSQTSSIFTVSRLNQTVRLLLEQEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIAESMQPAGEGLLQQKYEQLKAKLQAEGLFDQQHKQPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANARGECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEIVSRNQQELLRQIQSAQQRLGMAMDYYLANRSRRFTQIFHRLQQQHPQLRLARQQTALERLRQRMGFALEARIKQANQRQQRVSQRLSQQNPQPRIHRAQSRIQQLEYRLTENIRSRLSEQRERFGNAVTHLEAVSPLATLARGYTVSTTTDGKVLKKIKQVKAGDIMTTRLEDGWLESEVKSVTPGT
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP2AB_BACAN
Sequence: MRNEMNLQFSALSQNESFARVTVAAFIAQLDPTMEELTEIKTVVSEAVTNAIIHGYEGNAEGVVYISVILEEAMVKLTIRDEGIGIFNLDEARQPLFTTKPELERSGMGFTIMENFMDEVEVISNESFGTTIHLTKYLSNSNALCN
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: Y179_TREPA
Sequence: MTQALQVPSAPARCRHLRRKNGVLLRIVEKTDRTRYAHALRHGCRHRMCEGVHGTEEDAMGSESAEMDSPHATARPQEQGEDRAWDACGVWVKVPPEAQEPPVSSGGPEDPEAPAQHAPPGARVDAVRHHVYRALPVQSSAEDSRGFVDLSVEDEVLARGCSHAPGGESSSDQAADAPAGDAAYSEVPSFDDLVTRTAQSQDDRVDLSAAMSSVVTEEPPEPRGCSMPCPSGSCDTTEFDDLLSSLSHDAPEYPVDSDPITYSASEPSSEGPVRGAPFSDVDAVAQSLMGDAQVAAQGAQASTSGDASTDLLLKIAQEISSIRADLDQLKGTFSRQAGAEPAQAPATAPAPEGTEAAYSGFFCDDDPDETIALTNDELNNILITSEFTEEDGKDSAADAFGGELSGFESSHIGSAAGDFSYLEEDDHAAARVAQEQWVQQGRATLGNEVFDVKEQGAHADRDAAADPSPVAKDDASPEAQRAHVSSTGLDAAGAEQPLNTENVFDDEDTQREDTSFPLPEEQELDVSVPSLEFSAPHAIETAASESSEVATPVAIESPPQSEAARPAQGDSANLAPPLSKSLADEVRSVLGYMDRLLESLPEEKIEEFARSEYFHTYKHLFDELGIS
What are the official names of this protein?
Uncharacterized protein TP_0179.
Protein: RIBB_ECO81
Sequence: MNQTLLSSFGTPFERVENALAALREGRGVMVLDDEDRENEGDMIFPAETMTVEQMALTIRHGSGIVCLCITDDRRKQLDLPMMVENNTSAYGTGFTVTIEAAEGVTTGVSAADRITTVRAAIADGAKPSDLNRPGHVFPLRAQAGGVLTRGGHTEATIDLMTLAGFKPAGVLCELTNDDGTMARAPECIEFANKHNMALVTIEDLVAYRQAHERKAS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: YQGF_METFK
Sequence: MPEPAASSRGCVLGFDFGEKRIGVAIGEHLLGIAHPLVTIDAEANDKRFAAIAGLIEEWQPEMLVVGLPSYLNGDEHALTQLCRKFARRLEGRFNLPVQLVDERLSSAEASQTLKQSGISGRKQKSVLDQVAAQHILQSYFDGLAS
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_BACCQ
Sequence: MEARLKELKQKALELIEEAKELKGLNDVRVAYLGKKGPITEVLRGMGKLSAEERPRMGALVNEVREAIQTRLDDKISNLEKAVIEAKLATETIDVTLPGRPVETGCHHPLTAVVEQIEDVFIGMGYEVAEGTEVEKDYYNFEALNLPKDHPARDMQDTFYITEETLLRTHTSSVQARTMENNKEKGPIKIICPGKVYRRDDDDATHSHQFMQIEGLVIDKNIRMSDLKGTLQVFVKKMFGEDREIRLRPSFFPFTEPSVEMDISCMMCHGKGCGTCKGTGWIEILGAGMVHPNVLEMAGYDSKEYQGFAFGMGAERIAMLKYGVDDIRHFYTNDVRFLQQFKRA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPR_HUMAN
Sequence: MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELENLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN
What is the function of this protein?
Transcription coregulator that can have both coactivator and corepressor functions.  Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion.  In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid.  Acts as a coactivator for estrogen receptor alpha.  Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1.  Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases.  May also act as an inhibitor of cyclin A-associated kinase.  Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
What are the official names of this protein?
Centromere protein R, CENP-R, Beta-3-endonexin, Integrin beta-3-binding protein, Nuclear receptor-interacting factor 3.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Protein: SCPB_STRR6
Sequence: MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQKYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQPITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHLEELPVIDELEIQAQESQLFGERIEEDENQ
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: SAHH_BACFR
Sequence: MFYLCTTLYFKQFTFMSTELFSTLPYKVADITLADFGRKEIDLAEKEMPGLMALREKYGESKPLKGARIMGSLHMTIQTAVLIETLVALGAEVRWCSCNIYSTQDHAAAAIAASGVAVFAWKGETLADYWWCTLQALNFEGGKGPTVIVDDGGDATMMIHVGYEAENNAAVLDKEVHAEDEIELNAILKKVLAEDKERWHRVAAEVRGVSEETTTGVHRLYQMQEEGKLLFPAFNVNDSVTKSKFDNLYGCRESLADGIKRATDVMIAGKVVVVCGYGDVGKGCSHSMRSYGARVLVTEVDPICALQAAMEGFEVVTMEDACKEGNIFVTTTGNIDIIRIDHMEQMKDQAIVCNIGHFDNEIQVDALKHYPGIKRVNIKPQVDRYYFPDGHSIILLADGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFNKKYDINVYRLPKHLDEEVARLHLEKIGVKLTKLTPEQAAYIGVSVDGPYKADHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSH1_SOLLC
Sequence: MALMSQAGSSHCIYSEKVRCISGHRSIINNMDMFRMREICFGVDISSRNASRRVQGNYLNHIGVGSRRGDLTIVAASPPTEDAVVAAEPLTKEDLVGYLASGCKSKEKWRIGTEHEKFGFEFGTLRPMKYDQIADLLNGIAERFDWEKVMEGDKIIGLKQGKQSISLEPGGQFELSGAPLETLHQTCAEVNSHLYQVKAVAEEMGIGFLGTGFQPKWGLKDIPIMPKGRYEIIRNYMPKVGSLGLDMMFRTCTVQVNLDFSSEADMIRKFRAGLALQPIATALFANSPFTEGKPNGYLSKRSHIWTDTDNNRAGMLPFVFDDSFGFEQYVDYALDVPMYFVYRKKKYVDCTGLSFRDFMNGKLPPIPGEYPTLNDWENHLTTIFPEVRLKRYLEMRGADGGPWRRLCALPAFWVGILYDEGSLQSVLDMTFDWTAEERDMLRNKVPKSGLKTPFRDGLLMHVAQDVVKLAKEGLERRGFKETGFLNEVAEVVKTGVTPAEKLLELYHGKWGQSVDPIFEELLY
What are the official names of this protein?
Glutamate--cysteine ligase, chloroplastic, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the carboxylate-amine ligase family. Glutamate--cysteine ligase type 2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LMBR1_MOUSE
Sequence: MEGQDEVSAREQHFHSQVRESTICFLLFAILYIVSYFIIIRYKRKSDEQEDEDAVVNRISLFLSTFTLAVSAGAVLLLPFSIISNEILLAFPHNYYIQWLNGSLIHGLWNLASLFSNLCLFVLMPFAFFFLESEGFAGLKKGIRARILETLVMLLLLALLILGMVWVASALIDSDAASMESLYDLWEFYLPYLYSCISLMGCLLLLLCTPVGLSRMFTVMGQLLVKPAILEDLDEQIYMITLEEEALQRRLHGLSSSVEYNVMELEQELENVKILKTKLERRKKASAWERNLVYPAVMVLLLIETSISVLLVACNILCLLVDETAMPKGTRGPGIGSASLSTFGFVGAALEIILIFYLMVSSVVGFYSLRFFGNFTPKKDDTTMTKIIGNCVSILVLSSALPVMSRTLGITRFDLLGDFGRFNWLGNFYIVLSYNLLFAIMTTLCLIRKFTSAVREELFKALGLHKLHLSDTSRDSETTKPSANGHQKAL
What is the function of this protein?
Putative membrane receptor.
What are the official names of this protein?
Limb region 1 protein.
What is the protein family that this protein belongs to?
Belongs to the LIMR family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PURNU_GEOS3
Sequence: MPDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGDDRTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFATAVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAGGIAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPPESPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALFFSHRRDRGTTGRMLAFIGRREEWT
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine (PubMed:31978345).  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345).  Also has adenosine deaminase activity (PubMed:31978345).
What are the official names of this protein?
Purine nucleoside phosphorylase YlmD, Adenosine deaminase YlmD, S-methyl-5'-thioadenosine phosphorylase YlmD.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
Protein: AMPP2_BLAGS
Sequence: MISAIEPKNLLRPHSQPVVTTSTLQPDDECNIELRIEDTTVDKYPAKQHARRVAAEIHRDRGLVYLMGQKSTLYEDSDQERTFRQRRYFFYMSGVDEPDCDLTYDINADKLTLYVPDFDLKRTIWMGPTLGREEALQRFDIDEVKYQSSLDEDVKQWAQNQGRGSTLYLLHESQKPAEKVPNVFIDSKTLKQAMDTSRAIKDEHEIGLIRRANEVSAAAHIDVLRGIRKMSNERDIEASFLNTSVSLGAHKQAYHIIAASGSNAATLHYSKNNEPLKGRQFVCLDAGAEWNCYASDVTRTFPMTSQWPSAEAKHIYKLVEHMQESCMVRVKEGVRYLDLHILAHRSLIRGFLTLGIFKGGTLEEIQNSGASNLFFPHGLGHHIGLEVHDVSPESIMAQDNGDYSDNVLISPNNLSPCTTSSPTLKSGMVVTIEPGIYFSQIALDNAKPEQVKYVDLELVKTYMPVGGVRIEDDILVTKTGYENLTTAPKGDGMLEIIRQGDGSCNI
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase BDBG_08406, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: NLRX1_HUMAN
Sequence: MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSLTEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVEGEVRALLEQLGSSGS
What is the function of this protein?
Participates in antiviral signaling.  Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010).  Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352).  Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910).  Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).  Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity).  In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity).
What are the official names of this protein?
NLR family member X1, Caterpiller protein 11.3, CLR11.3, Nucleotide-binding oligomerization domain protein 5, Nucleotide-binding oligomerization domain protein 9.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane.
Protein: DUT_CLOTE
Sequence: MTEYTLKIKLLKEDAKLPQYAHDNDAGMDLFSTEDKIINPGKHALILTGISIELPENTEAQIRPRSGLALKNGVTVLNTPGTIDAGYRGEIGIILINHGEKNFQVEKGMKIAQMVIKPIVKVNIEEVKMLSESQRGKGGFGSTGK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ARLY_CLOPE
Sequence: MKLWGGRFTHQVDDLVNTFNSSISFDSRMYKEDIIGSIAHVTMLGEEKIIPKEDSKKIASGLYEILDKLNQGVLKIDNSSEDIHSFIESTLTDYIGEEGKKLHTGRSRNDQVTLDTKLYLKGYIKILICEILNLEKTLLNLSSENKETIMPGYTHMQKAQPITFAHHILAYSEMFKRDISRLLDCYKRLDEMPLGSGALATTTYPINREKVSELLGFSKVTLNSLDSVSDRDYAIETLSCLSLLMMHLSRFSEEIIIWSTDEFKFIELDDSYSTGSSIMPQKKNPDVAELVRGKTGRVYGDLMTLLTVMKGLPLAYNKDMQEDKEALFDGLDTTLLSIKTFNGMIKTMKINKSLMKTSASSGFTNATDVADYLVKKGVAFRDAHEIVGNLILYCIDEGKSIDNLSLSEFKTFSNKFENDIYKAINLLTCIEERKVIGGPSISSINIQIEHLNNFIQESNEKLNFLK
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTVE_ASPTN
Sequence: MFRLSSGLLKGGACASRSRIPQLGRSLYSTATSAGADKTQGKIHTVIGAVVDVQFNHGRLPPILNALETTNQGKKLVLEVAQHLGEHTVRCIAMDGTEGLVRGTAVADTGNPIMVPVGPATLGRIMNVTGDPIDERGPIEGVRLMPIHTEPPAYTEQSTHAEILVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMQETGVIKLDGDSKVALVFGQMNEPPGARARVALTGLTIAEYFRDEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAVDMGAMQERITTTTKGSITSVQAVYVPADDLTDPAPATTFIHLDATTELSRGISELGIYPAVDPLGSKSRLMDPRIVGEEHYDTAMRVQRTLQEYKSLQDIIAILAGVA
What is the function of this protein?
ATP synthase subunit beta; part of the gene cluster that mediates the biosynthesis of citreoviridin, an inhibitor of the of F1-ATPase beta-subunit (PubMed:26954888).  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (By similarity).  Whereas ctvA to ctvD constitute the core biosynthetic gene cluster, ctvE acts as a self-resistance gene (PubMed:26954888).
What are the official names of this protein?
ATP synthase subunit beta, mitochondrial, Citreoviridin biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein (By similarity).
Protein: GLRX1_RICBR
Sequence: MNKAILHAIIIYTLAGCPYCMKAKALLDKKEVAYEEIEVQNSQDPNVAVLRKKLNNPDRLTFPQIFIDNMHIGGCDDLYDLDKEGRLDKLLEGQPKKD
What is the function of this protein?
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase.  Reduces low molecular weight disulfides and proteins (By similarity).
What are the official names of this protein?
Glutaredoxin 1.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_STAA1
Sequence: MKAKEIRDLTTSEIEEQIKSSKEELFNLRFQLATGQLEETARIRTVRKTIARLKTVAREREIEQSKANQ
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: LAMP5_RAT
Sequence: MDLRGRALLGGDRLRILLMFFHAMAQTVAEQEVENLSGLSTNPEKDIFVVRENGTTCLMAEFAAKFIVPYDVWASNYVDLITEQAEISLTRGAEVKGRCGHNESELQVFWVDRAYTLKMLFVKESHNTSKGLEATWKLSKVQFVYDSSEKTHFKDAVSAGKHTANSHHLSALVTPAGMSYECQAQQTISLASSDPQKTVTMILSAVHIQPFDIISDFVFSEEHKCPVDEREQLEETLPLILGLILGLVIVITLVIYHIHHKMTANQVQIPRDRSQYKHMG
What is the function of this protein?
Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
What are the official names of this protein?
Lysosome-associated membrane glycoprotein 5, Brain and dendritic cell-associated LAMP, Brain-associated LAMP-like protein, BAD-LAMP, Lysosome-associated membrane protein 5, LAMP-5.
What is the protein family that this protein belongs to?
Belongs to the LAMP family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein. Cell projection, growth cone membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Note=Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles (By similarity). Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (By similarity). Associates with cortical membranes (By similarity). Localizes mostly in cytoplasmic vesicles of neuronal cell body. Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity).