PharMolix/UniProtQA huggingface dataset:
Protein: WAPA_STRMU
Sequence: MKMKRKLLSLVSVLTILLGAFWVTKIVKADQVTNYTNTASITKSDGTALSNDPSKAVNYWEPLSFSNSITFPDEVSIKAGDTLTIKLPEQLQFTTALTFDVMHTNGQLAGKATTDPNTGEVTVTFTDIFEKLPNDKAMTLNFNAQLNHNNISIPGVVNFNYNNVAYSSYVKDKDITPISPDVNKVGYQDKSNPGLIHWKVLINNKQGAIDNLTLTDVVGEDQEIVKDSLVAARLQYIAGDDVDSLDEAASRPYAEDFSKNVTYQTNDLGLTTGFTYTIPGSSNNAIFISYTTRLTSSQSAGKDVSNTIAISGNNINYSNQTGYARIESAYGRASSRVKRQAETTTVTETTTSSSSETTTSEATTETSSTTNNNSTTTETATSTTGASTTQTKTTASQTNVPTTTNITTTSKQVTKQKAKFVLPSTGEQAGLLLTTVGLVIVAVAGVYFYRTRR
What are the official names of this protein?
Wall-associated protein.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor.
Protein: COAD_SERMA
Sequence: MTSKAIYPGTFDPMTNGHLDLVTRASLMFDHVILAIAASPSKKPLFSLDERVALATQVTSHLDNVEVLGFSELMAHFAAHQNANILVRGLRAVSDFEYELQLANMNRHLMPTLESVFLMPSEEWSFISSSLVKEVARHGGDIAPFLPDVVTQALMAKLAAA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOCD_ACIB5
Sequence: MAETDIAMPESTPVDSRPAFAIVEELKTKFGENFYVQATFEEFPTVWVERARVQEVLMFLRKVERPYVMLFDLSAMDERLRQHRDGLPASDFTVFYHLLSLERNSDIRIKVALNENDLNLPTATNIWPNANWYEREAYDMFGINFEGHPMLRRILLPTYWEGHPLRKEYSARATEYTPYMQDKAKQDFEQEHLRFVPEDWGLKRGNADEDFMFLNLGPNHPSAHGAFRIVLQLDGEEVKDCVPDIGYHHRGVEKMAERQTWHSFIPYTDRVDYLGGCAQNMPYVMAVEQLAGIKVPERAQVIRVMLNELFRINNHLLYCGTAIQDAGGMTPVFYMFADRQKVYDIVEAITGYRMHPAWFRIGGTAHDLPNNWQKLVKELLDWMPKRLNEYYTAAFKNSVFIGRTRNVAQYDAKSALAWGVTGTGLRATGIDFDVRKYRPYSGYENFDFEVPVEYEGDAYARVLVHFREIEQSLKIIKQCLDNMPSGPYKADHPLAVPPPKDKTLQDIETLITHFLSVSWGPVMPAGEASFMTEVVKGASTYYLTSDKATMSYRTRIRTPTFTHLQQIPSVINGSLVSDLIIYLATIDVVMADVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RLMH_SODGM
Sequence: MRLQLIAIGTKMPDWVQTGFSDYLKRFPKDLPFDLTEIAAGKRGKNADIARILDKEGEQMLAAVAKGNRIVTLDIPGARWETPRLAQQLERWKQDGRDVSFLIGGPEGLAPACKAGAEQSWSLSPLTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGRB_SALNS
Sequence: MKKFRWVVLGIVVVVCLLLWAQVFNIMCDQDVQFFSGICAINKFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: METXS_BURTA
Sequence: MESIGVVAPHTMHFAEPLRLQSGSVLGNYQLVVETYGELNAARSNAVLVCHALNASHHVAGVYADDPRSTGWWDNMVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMSIDPATGTPYGARFPVVTVEDWVHAQARVADAFGIERFAAVMGGSLGGMQALAWSLLYPERVAHCIDIASTPKLSAQNIAFNEVARSAILSDPDFHGGDYYAHGVKPRRGLRVARMIGHITYLSDDDMAEKFGRALRRADGALDAYNFNFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFNGNLSAALAHTKAKYLVASFTTDWRFAPARSREIVKALLDNRRSVSYAEIDAPHGHDAFLLDDARYHNLVRAYYERIAEEVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RZ22A_ARATH
Sequence: MSRVYVGNLDPRVTERELEDEFRSFGVIRSVWVARRPPGYAFLDFEDSRDARDAIREVDGKNGWRVEQSHNRGGGGGRGGGRGGGDGGRGRGGSDLKCYECGESGHFARECRSRGGSGGRRRSRSRSRSPPRYRKSPTYGGRRSYSPRARSPPPPRRRSPSPRGRNYSRSPPPYRARDEVPYANGNGLKDVRRSRS
What is the function of this protein?
Probably involved in intron recognition and spliceosome assembly.
What are the official names of this protein?
Serine/arginine-rich splicing factor RSZ22A, RS-containing zinc finger protein 22A, At-RSZ22a, At-RSZp22a, AtRSZ22a.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family. RSZ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: QULF_PENCI
Sequence: MPPVNFGSYQTKIYHDGTNLNRLPAITTNPTLLEKHAREVLSSRAYSYIAGGAGEKSTMEANRLAFRQWKLVPRVMRPMDDQSISVNLFGQEYKSPLIVGPVGVQGLFHRDKETGVAQVCSELDVPYTLSTASSSSIEDVAAANQAGHRWFQLYWVHDEEILLSLLKRAKENGFTVLVVSLDTWTLGWRPTDLDQGYFPFYAGIGNDVGFSDPVFRAKHEKKGGKIEDDIIGAANAWVSELDDRPHTWEQVEFLRKHWQGPIVLKGIQHADDARRALETGCEGLVVSNHGGRQVDGAIGSLDALPDIVDAVGDKMTVMFDSGVRTGADVIKALCLGAKAVLVGRPVIYGLAIGGKEGAKSVIECLLADLWQGMGLAGMRTVADCNRDCMRRISYPGDLKTML
What is the function of this protein?
FMN-dependent alpha-hydroxy acid dehydrogenase; part of the gene cluster that mediates the biosynthesis of quinolactacin A2 (QUL A2), a fungal alkaloid that features a quinolone-gamma-lactam hybrid, which is a potential pharmacophore for the treatment of cancer and Alzheimer's disease (PubMed:32663343).  The quinolone-gamma-lactam hybrid scaffold is synthesized from the combination of L-isoleucine (L-Ile) and the nonproteinogenic amino acid L-kynurenine, followed by quinolone cyclization, oxidative decarboxylation, and lactam formation (PubMed:32663343).  Additionally, the N-methyl group is derived from methionine, which might be catalyzed by an S-adenosylmethionine (SAM)-dependent methyltransferase (PubMed:32663343).  Bioconversion of L-tryptophan to L-kynurenine could be catalyzed by the indoleamine-2,3-dioxygenase (IDO) qulI to produce an unstable product, N-formyl-L-kynurenine, followed by kynurenine formamidase catalyzed hydrolysis (PubMed:32663343).  QulM then acts as a methyltransferase that methylates L-kynurenine at the N-4 position (PubMed:32663343).  The FMN-dependent alpha-hydroxy acid dehydrogenase qulF than functions as an oxidative decarboxylase which converts N-methylkynurenine into 2-aminobenzoylacetamide via 2 tandem reactions, including dehydrogenation and decarboxylation (PubMed:32663343).  An amidase located outside of the qul gene cluster further produces the unstable beta-keto acid precursor N-methyl-2-aminobenzoylacetate, which could be spontaneously dehydrated to form N-methyl-4-hydroxy-2-quinolone (PubMed:32663343).  The NRPS qulB is able to incorporate N-methyl-2-aminobenzoylacetate and efficiently compete with the spontaneous reaction (PubMed:32663343).  By further extending the beta-keto acid with L-Ile, qulA performs a Dieckmann condensation to form the gamma-lactam ring and release a 4-ketopyrrolidinone intermediate from the assembly line (PubMed:32663343).  This intermediate could plausibly further undergo a spontaneous cyclization to yield the final quinolone-gamma-lactam hybrid structure (PubMed:32663343).
What are the official names of this protein?
FMN-dependent alpha-hydroxy acid dehydrogenase qulF, Quinolactacin A2 biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
Protein: HSP70_SCHJA
Sequence: ERTMTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSAVDKATGKENKITITNDKGRLSKEEIDRMINEADRYKSEDEKQKNRICAKNSLESYVYSMKQSVEGDEMKDKISESDRKNRILSKCEETIRWMDNNQLAEKEEFEEKKSELEKVCMPIITAMNRAGGGVPSGMPGGMPGAGGGGGKGPTIEEVD
What are the official names of this protein?
Heat shock 70 kDa protein, HSP70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PLSX_SHEB2
Sequence: MTNLTLALDAMGGDHGPHVTVPAALRALQLHSFLKIILVGDKTEIDVYLRQAEANLLSRIEIIHTDEVVSMSDRPVHALRTRKNSSMRLAIELVRDDCAQACVSAGNTGALMAMAKVLLKTLPGVDRPALVSCLPAVTQKPVYLLDLGANISCDSETLFQFAVMGSVLCEAVDKKSRPKVALLNVGIEEIKGNDQVQQAAQLLQHTDQINYTGFIEGDEIYSGNVDVIVCDGFVGNITLKTSEGIAKLLVHQLKRGLTQGLFVRFLAKLIAPRIQAVLSQMNPDHYNGASLIGLRGIVVKSHGNADETAYLQAISLAVTEAQRRLPEMIKDRLESILLDINH
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: SP5G_BACSU
Sequence: MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLFVAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS
What is the function of this protein?
Essential for sporulation.  Interferes with or is a negative regulator of the pathway leading to asymmetric septation.
What are the official names of this protein?
Putative septation protein SpoVG, Stage V sporulation protein G.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: MK07_BOVIN
Sequence: MAEPLKEDDGEDGSGEPPGPVKAEPAGTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMTVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARVSAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPLPCPGPAPDTIDLTLQPPPPASEPAPPKKEGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGVSGGPSADPLAGLVLSDNDRSLLERWTRMAQPPAPAPATARPPSPPAGPATQPTGPLPQPACPPPAPAAGPAAPQTTAASGLLAPQPLVPPPGLPGPSALSVLPYFPSGPPPPDPGGAPQPSTSESPDVTLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQEP
What is the function of this protein?
Plays a role in various cellular processes such as proliferation, differentiation and cell survival.  The upstream activator of MAPK7 is the MAPK kinase MAP2K5.  Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C.  EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway.  May have a role in muscle cell differentiation.  May be important for endothelial function and maintenance of blood vessel integrity.  MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.  Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity).  Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase 7, MAP kinase 7, MAPK 7.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
Protein: CH60_BEUC1
Sequence: MAKIIAFEEEARRGMERGLNHLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEEPFEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPIALKKGIDKAVEAVTAALLEQAKEVETKEEIAATAGISAGDPAIGELIAEALDKVGKEGVITVEESNALGLELELTEGMRFDKGYLSAYFVTDQERQEAVLEDAYILLVESKISSVKDLLPLLEKVIQGGKSLVIIAEDIEGEALATLVVNKLKGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISETVGLSLENADLDALGQARKIVVTKDETTIVEGAGDPDQLAGRVAQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALIQAGKVAFETLELVGDESTGGNIVKVAIDAPLKQIAINAGLEGGVVAEKVRSLPAGHGLNAATGDYEDLLAAGINDPVKVTRSALQNAASIAGLFLTTEAIVADKPEKASAPAGGGDGDMGGMGF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXB_ACIBY
Sequence: MKIVADENLAFTDYFFSEFGDIQHKAGRTLTHTDVQDAEALLVRSVTAVNESLIQNTALKYVGSATIGTDHLDIQALEKHGITWANAAGCNAQAVAEYVITALLHLDASLLEQQEKFTLGIVGLGNVGKRLVYMAQLLGWKVIGFDPYVQLDSIENVSFQALLQQANAVSIHVPLTKKGEHATYHLFDEKAFAALQPNTILINSARGPVVKEAALIEDIQRTQRKVVLDVFEHEPVISEELLNMLALATPHIAGYSLEGKARGTQMIYEAFCQKFGYEINKRFETQLPACEDYFSGHDLKAVLKQKLSQIYDIAQDDANIRACVKEGKVEQKAFDLLRKNYPLRREWAAHGGPQA
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCX2_CENEX
Sequence: MNSLLMITACLALIGTVWAKEGYLVSKSTGCKYECFWLGKNEGCDKECKAPNQGGGYGYCHAFACWCENLPESTPTYPIPGKSCGKK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Neurotoxin Cex2.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CYTB_PANTR
Sequence: MMCGAPSATQPATAETQHIADQVRSQLEEKENKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEEFVHLRVFQSLPHENKPLTLSNYQTNKAKHDELTYF
What is the function of this protein?
This is an intracellular thiol proteinase inhibitor.  Tightly binding reversible inhibitor of cathepsins L, H and B (By similarity).
What are the official names of this protein?
Cystatin-B, Stefin-B.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: IDI_AGRME
Sequence: MTDLSITPLPAQAAPVQPASSAELVVLLDEAGNQIGTAPKSSVHGADTALHLAFSCHVFDDDGRLLVTRRALGKVAWPGVWTNSFCGHPAPAEPLPHAVRRRAEFELGLELRDVEPVLPFFRYRATDASGIVEHEICPVYTARTSSVPAPHPDEVLDLAWVEPGELATAVRAAPWAFSPWLVLQAQLLPFLGGHADARVRTEALVS
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMPR_MYCGS
Sequence: MATPTPFQSQIYRSLPEIERADAIVERISKAIALGLLKVGERLPPEAALSEMFGVGGATLREALSELRERGVVETRRGRSGGTFVVNQPEPETDIMREWFLSTSISEIRDIGDEHSAIAAATIRLACERAEAHDFDRLQELARALVLAETPETRASADSRFHIELAVSAQSPRLANAEIRLQEETVRQLWAPFTVAEAYDPERATAEHLELVRAVAQDQPERAQKLTLEHIRRNIFHLIDTKLVLGYAQSRPSSPATAPDGSSSAEAAMIQEGQ
What is the function of this protein?
May regulate the transcription of the rmpAB operon.
What are the official names of this protein?
Putative HTH-type transcriptional regulator RmpR, DNA-binding regulatory protein RmpR.
Protein: RUTE_ECO27
Sequence: MNEAVSPGALSTLFTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFIRTAEGKERLRPALSSGNLQKTLTAPVTAIVAWDSEFYERLPQLFPHGDARSWFTSSPQLAEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQYVDDAFFAGSTLKSNLLINIGYGDSSKLFARLPRLSFEEACGLL
What is the function of this protein?
May reduce toxic product malonic semialdehyde to 3-hydroxypropionic acid, which is excreted.
What are the official names of this protein?
Probable malonic semialdehyde reductase RutE.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family. HadB/RutE subfamily.
Protein: RL38_PLUXY
Sequence: MPREIKDIKDFLLKARRKDAKSVKIKKNPENVKFKVRCSRFLYTLVITDKEKAEKLKQSLPPGLQVKEVK
What are the official names of this protein?
60S ribosomal protein L38.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL38 family.
Protein: TUSC_SALEP
Sequence: MKRIAFVFSTAPHGSASGREGLDALLATSALTEALGVFFISDGVFQLLPGQKPDAVLARDYIATFKLFDLYDIDQCWICAASLRERGLENVNFVVDATPLEPVALRRELGNYDVILRF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_HAEIG
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDSKCKIDTAPGQHGARKPRLSDYGSQLREKQKVRRIYGILERQFRNYYKEANRLKGNTGENLLVLLEGRLDNVVYRMGFAATRAEARQLVSHKAIVVNGRVVNIPSFQVSVNDVVAIREKSKKQARIKASLELAEQREKPTWLEVDSAKMEGVFKRVPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: IHFB_SALG2
Sequence: MTKSELIERLATQQSHIPAKAVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: STE3_YEAST
Sequence: MSYKSAIIGLCLLAVILLAPPLAWHSHTKNIPAIILITWLLTMNLTCIVDAAIWSDDDFLTRWDGKGWCDIVIKLQVGANIGISCAVTNIIYNLHTILKADSVLPDLSSWTKIVKDLVISLFTPVMVMGFSYLLQVFRYGIARYNGCQNLLSPTWITTVLYTMWMLIWSFVGAVYATLVLFVFYKKRKDVRDILHCTNSGLNLTRFARLLIFCFIIILVMFPFSVYTFVQDLQQVEGHYTFKNTHSSTIWNTIIKFDPGRPIYNIWLYVLMSYLVFLIFGLGSDALHMYSKFLRSIKLGFVLDMWKRFIDKNKEKRVGILLNKLSSRKESRNPFSTDSENYISTCTENYSPCVGTPISQAHFYVDYRIPDDPRKSQNKSKKYLFADKETDDILDEIDLKESRHIPYVTQGQSFDDEISLGGFSKVTLDYSEKLHNSASSNFEGESLCYSPASKEENSSSNEHSSENTAGP
What is the function of this protein?
Receptor for the peptide pheromone a factor.
What are the official names of this protein?
Pheromone a factor receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 4 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NORK_MEDTR
Sequence: MMELQVIRIFRLVVAFVLCLCIFIRSASSATKGFESIACCADSNYTDPKTTLTYTTDHIWFSDKRSCRQIPEILFSHRSNKNVRKFEIYEGKRCYNLPTVKDQVYLIRGIFPFDSLNSSFYVSIGVTELGELRSSRLEDLEIEGVFRATKDYIDFCLLKEDVNPFISQIELRPLPEEYLHGFGTSVLKLISRNNLGDTNDDIRFPDDQNDRIWKRKETSTPTSALPLSFNVSNVDLKDSVTPPLQVLQTALTHPERLEFVHDGLETDDYEYSVFLHFLELNGTVRAGQRVFDIYLNNEIKKEKFDVLAGGSKNSYTALNISANGSLNITLVKASGSEFGPLLNAYEILQARSWIEETNQKDLEVIQKMREELLLHNQENEALESWSGDPCMIFPWKGITCDDSTGSSIITKLDLSSNNLKGAIPSIVTKMTNLQILNLSHNQFDMLFPSFPPSSLLISLDLSYNDLSGWLPESIISLPHLKSLYFGCNPSMSDEDTTKLNSSLINTDYGRCKAKKPKFGQVFVIGAITSGSLLITLAVGILFFCRYRHKSITLEGFGKTYPMATNIIFSLPSKDDFFIKSVSVKPFTLEYIEQATEQYKTLIGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRIEWSLVEWAKPYIRASKVDEIVDPGIKGGYHAEALWRVVEVALQCLEPYSTYRPCMVDIVRELEDALIIENNASEYMKSIDSLGGSNRYSIVMDKRALPSTTSTAESTITTQTLSHPQPR
What is the function of this protein?
Involved in the perception of symbiotic fungi and bacteria.  Part of the perception/transduction system leading to nodulation or mycorrhizal infection (PubMed:12087406, PubMed:12087405).  Phosphorylates PUB1 (PubMed:26839127).
What are the official names of this protein?
Nodulation receptor kinase, Does not make infections protein 2, MtSYMRK, Symbiosis receptor-like kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AKT3_MOUSE
Sequence: MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDDDGMDGMDNERRPHFPQFSYSASGRE
What is the function of this protein?
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis.  This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates.  Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported.  AKT3 is the least studied AKT isoform.  It plays an important role in brain development and is crucial for the viability of malignant glioma cells.  AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13.  Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands.  Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
What are the official names of this protein?
RAC-gamma serine/threonine-protein kinase, Protein kinase Akt-3, Protein kinase B gamma, PKB gamma, RAC-PK-gamma.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.