PharMolix/UniProtQA huggingface dataset:
Protein: ANGP1_CANLF
Sequence: MTVFLSFAFLAAILTHIGCSNQRRSPENGGRRYNRIQHGQCAYTFILPEHDGNCRESTTDQYNTNALQRDAPHVGPDFSSQKLQHLEHVMENYTQWLQKIENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEEWDTLKEERENLQVLVTRQTYIIQELEKQLNRATNNNSVLQKQQLELMDTVHNLVNLCTKEVLLKGGKKEEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYTLRIELMDCEGNRAYSQYDRFHIGNEKQNYRLYLKCHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF
What is the function of this protein?
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation.  Implicated in endothelial developmental processes later and distinct from that of VEGF.  Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.  Mediates blood vessel maturation/stability.  It may play an important role in the heart early development (By similarity).
What are the official names of this protein?
Angiopoietin-1, ANG-1.
What are the subcellular locations of this protein?
Secreted.
Protein: TSK_MOUSE
Sequence: MLCSLFLLLLAVGRVQTTRPCFPGCQCEEETFGLFDSFSLIRVDCSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLAGPGYTTLAGLDLSYNLLTSIMPSAFSRLRYLESLDLSHNGLAALPAEIFTSSPLSDINLSHNRLREVSISAFTTHSQGRALHVDLSHNLIHRLLPHPARASLPAPTIQSLNLSWNRFRAVPDLRDLPLRYLSLDGNPLATINPDAFMGLAGLTHLSLASLQGILHLPPHGFRELPGLQVLDLSGNPKLKWAGAEVFSGLGLLQELDLSGSSLVPLPEMLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSPKVVLHCGDTQESAARGPDIL
What is the function of this protein?
Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways (PubMed:21856951, PubMed:22995554, PubMed:25159578, PubMed:31391339).  Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye (PubMed:21856951).  Plays a role in regulating the hair cycle by controlling TGFB1 signaling (PubMed:22995554).  Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth (PubMed:21055390, PubMed:23206892).  Essential for terminal differentiation of hippocampal neural stem cells (PubMed:31983064).  Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size (PubMed:30271858).  Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells (PubMed:32127020).  Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence (PubMed:25159578).  Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver (PubMed:31391339).  In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure (PubMed:31535079).  In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis (PubMed:31767170).
What are the official names of this protein?
Tsukushi, Leucine-rich repeat-containing protein 54.
What are the subcellular locations of this protein?
Secreted.
Protein: HYPF_AZOVI
Sequence: MNQPAEAGVRLLLRGRVQGVGMRPCVHRLATSLGLAGEVRNTGAGVRIDLLGPPQALAEFERRLPDELPPLARLDAIQREPLPAGTRFAGFAIAASRDERRGALAPPPDAAVCPACLEELFDPHDRRWRHPFINCTHCGPRYSLIRRLPYDRVQTSLAGFELCPECRREYEDPADRRFHAQPIACPACGPRLCCEDASGRRLSGDPIERALAALARGEILALRGVGGFHLACDARNAGAVAELRRRKRRPAKPFALMAANPASLQALVELNENGLAELSGPAAPVVLLRKRPAADDLLAAGVAPDLAWLGAMLPHSPLHWLLFHEAAGRPAGTGWAAAPQDLLLVMTSANLSGAPPITGNAEARERLAGIADLWLLHDREILNRCDDSVVSALGRAPLVIRSGRGLAPLEIPLARGGPSILALGGQLKNAVCLTRGDRAWLSPHNGDLDDADTCRALERTVARLGELLGIRPERVACDLHPDFFASRFARDYAERHGLPLHPIQHHHAHIAATMAEHGLAEPVLGLALDGFGLGADGRLRGGELLRVAADGCAWLGELNPLPLPGGDQASREPWRMAAGALHALGRGGEIATRFAAEPGNAAIARMLERGFNCPPSSSAGRLFDAAAGLLGLGGRQRYEAEAALRLESRVVGLPERVPALWRIDDDNRLDLLPLLARLADMRDTRAGAELFHGVLIEALAIWAARAAEATGLHRVALGGGCFLNTVLRDGLCARLRAAGLTPLLARRAPLNDGGLALGQAWAVLLAADIPSTRGQA
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases.  HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
What are the official names of this protein?
Carbamoyltransferase HypF, Carbamoyl phosphate-converting enzyme HypF, [NiFe]-hydrogenase maturation factor HypF, Hydrogenase maturation protein HypF.
What is the protein family that this protein belongs to?
Belongs to the carbamoyltransferase HypF family.
Protein: MTNC_SERP5
Sequence: MIRAIVTDIEGTTSDIRFVHQVLFPYARERLATFLRLHAEDAEVAAPLTALRQELDQPQADIEQLIAALYRFMDEDRKSTALKALQGIIWRSGYQNGDFRGHLYPEVAGQLAAWQQQGLKLYVYSSGSVEAQKLLFGYSDAGDLQPLFSGYFDTHVGAKRETASYLNIAGKIGIAADELLFLSDIHQELDAARAAGWHTCQLIRDEADSQSQHPQVNRFDQIDLGEFAS
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: Y1598_DESAP
Sequence: MEIRLINIGFGNIVSANRIVAIVSPESAPIKRMITEARDRGMLIDATYGRRTRAVIITDSDHVILSAVQPETVAHRLVSKMEQAHHHHHGDNGKD
What are the official names of this protein?
Putative regulatory protein Daud_1598.
What is the protein family that this protein belongs to?
Belongs to the RemA family.
Protein: MCRX_METTM
Sequence: MDEKKLFLKALKKKFEGEDPDEKYTNFYCFGGWEQSARKKEFTEYAKKAAEKRGGIPFYNPDIGVPLGQRKLMAYRVSGTDAYVEGDDLHFVNNAAIQQMVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMEAINHALPGGAVVQEHMVEVHPGLVEDCYAKIFTGDDNLADELDKRILIDINKEFPEEQAEQLKSYIGNRTYQVNRVPTIVVRTCDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVIEMGTIMPARRARGPNEPGGVAFGTFADIVQTSRVSDDPANVSLEVIAGAAALYDQVWLGSYMSGGVGFTQYATAAYTDDILDDFVYYGMEYVDDKYGICGTKPTMDVVRDISTEVTLYSLEQYEEYPTLLEDHFGGSQRAAVAAAAAGCSTAFATGNSNAGINGWYLSQILHKEAHSRLGFYGYDLQDQCGASNSLSIRSDEGLIHELRGPNYPNYAMNVGHQPEYAGIAQAPHAARGDAFCTNPLIKVAFADKDLAFDFTSPRKSIAAGALREFMPEGERDLIIPAGK
What is the function of this protein?
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB).  This is the final step in methanogenesis.
What are the official names of this protein?
Methyl-coenzyme M reductase II subunit alpha, MCR II alpha.
What is the protein family that this protein belongs to?
Belongs to the methyl-coenzyme M reductase alpha subunit family.
Protein: DAPA_AROAE
Sequence: MITGSLVAIVTPMHEDGSLDYPRLRSLIDFHVAEGTDGIVVVGTTGESPTVNVEEHCELIRTTVEHAAGRIPVIAGAGGNSTAEAIELASFAQEAGAVAQLSVVPYYNRPTQEGLYRHFRSIAEAVELPLILYNVPGRTVADLSNDTTLRLAEIPNIIGIKDATGSIDRACDLIERAPKDFALYTGDDMSAAAFILLGGHGTISVTANVAPRAMHEMCAAALAGEALRVREINGRLVGLHRDLFCEANPIPVKWAVARMGLIESGIRLPLTPLSSASQERVLLAMRRAGVNV
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMC7_MACFA
Sequence: MSESSASALQLGRPSRQPAVHPENLSLDASCFSSPPVNFLQELPSYRSIARRRTTVHSRDKQSGTLLKSTDSYSSQLEDRIAENLSSQSLRNYALNISEKRRLRDIQETQMKYLSEWDQWKRYSSKSWKRFLEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMLVLLPILLTKYKITNSSFVLIPFKDTDIQCTVYPVSSSGLIYFYSYIIDLLSGTGFLEETSLFYGHYTIDGVKFQNFTYDLPLAYLISTIAYLALSLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITNRSMADLKHSSLRYELRADLEEERIRQKIAERTSEETIRIYSLRLFLNCIVLAVLGACFYAIYVATVFSQEHMKKEIDKMVFGENLLILYLPSIVITLANFITPMIFAKIIRYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKITSCDDDTCDLCGYNQKLYPCWETQVGQEMYKLMIFDFIIILAVTLFVDFPRKLLVTYCSSWKLIQCWGQQEFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEWSLLYTCRPSPRPFRASNSNFFFLLVLLIGLCLAIIPLTISISRIPSSKACGPFTNFNTTWEVIPKTVSTFPSSLQSFIHGVTSEAFAVPFFMIICLIMFYFIALAGAHKRVVIQLREQLSLESRDKRYLIQKLTEAQRDTRN
What is the function of this protein?
Probable ion channel.
What are the official names of this protein?
Transmembrane channel-like protein 7.
What is the protein family that this protein belongs to?
Belongs to the TMC family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PSK1_ORYSI
Sequence: MVNPGRTARALCLLCLALLLLGQDTHSRKLLLQEKHSHGVGNGTTTTQEPSRENGGSTGSNNNGQLQFDSAKWEEFHTDYIYTQDVKNP
What is the function of this protein?
Promotes plant cell differentiation, organogenesis and somatic embryogenesis as well as cell proliferation.
What are the official names of this protein?
Phytosulfokines 1.
What is the protein family that this protein belongs to?
Belongs to the phytosulfokine family.
What are the subcellular locations of this protein?
Secreted.
Protein: THIG_NITSB
Sequence: MADILKIGKYEFTSRLIVGSGKYPDFKTTYDATIASGAQMITVAVRRVNITDPNKENLMDYFKDSDVQLLPNSAGCTTAEEAITLFRMVREATGIDIIKLEIIGDTEKTLYPDVIETIKACEVLANDGFTVMAYTNDDPITAKKLENAGAAAVMPLAAPIGSGLGIQNRYNVVFVKEAVNVPVIVDAGVGCASDAAIAMELGADGVLTNTAIAQAKNPIQMAEAMKYAVIAGRMSYLAGRIPKKPYATASSPSEGMIQF
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLB1_ASPFC
Sequence: MKTTTVACAVAGLLFSCVSGAPDPVHVEIQQRALPNAPDGYTPSTVGCPASRPTIRSAASLSPNETSWLETRRGKTTSAMKDFFNHVKIQDFDAAGYIDRHSSNSSDLPNIGIAVSGGGYRALMNGAGAIKAFDSRTPNSTSAGQLGGLLQSATYLSGLSGGSWLVGSIYINNFTTISALQTHQKGTVWQFQNSIFEGPDGGSIQILDSATYYRDISNAVSGKSDAGYPTSITDYWGRALSYQMINATNGGPSYTWSSIALTDAFQKAEMPMPLVVADGRYPGELLISSNATVYEFNPWEFGTFDPTVFGFAPLEYLGTKFNGGSVPSNESCVRGFDNVGFVMGTSSTLFNQFLLQINSTALPDWLKSVFTDILKDIGENDEDIAQYAPNPFYHFSNTTNPSAAELELDLVDGGEDLQNIPLHPLIQPERHVDVIFAVDSSADTTYSWPNGTALVATYERSLNSSGIANGTSFPAIPDQNTFVNKGLNTRPTFFGCNSSNTTGPSPLIVYLPNYPYTAYSNFSTFQPDYTEQERDSTILNGYDVVTMGNSTRDGNWSTCVGCAILSRSLERTNTNVPEICKQCFQRYCWDGSLNSTTPAGYEPVTILDSAASGIIPSISTVAMAVVFAAWTIF
What is the function of this protein?
Catalyzes the release of fatty acids from lysophospholipids.
What are the official names of this protein?
Lysophospholipase 1, Phospholipase B 1.
What is the protein family that this protein belongs to?
Belongs to the lysophospholipase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: RL24_HERA2
Sequence: MHVKKGDRVVVLSGREKGREGVIKLSLPKKERVVVENVNIVKKHVKPMGNRQGGILEVEAALHVSKVMLICPACGKPSRTGHRVNDEGKKVRVCKQCNADVA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: DPDS_MYCLE
Sequence: MVRNERTLKSTDFPQLPPAPDDYPTFPDKSTWPVVFPMLPPSPDGGPRRPPQHTSKAVAPRLSAAQLPTHVAIVMDGNGRWANQRGLHRTEGHKMGEAVVIDVACGAIELGIKWLSLYAFSTENWKRSVEEVRFLMGFNRDVVRRRRENLKEMGVRIRWVGSRPRLWRSVINELAIAEHMTAGNDVITINYCVNYGGRTEIAEATREIARLAAAGRLNPERITESTITRHLQRPDIPDVDLFVRTSGEQRSSNFMLWQAAYTEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate.  When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and (2E,6E,10E)-geranylgeranyl diphosphate (EEE-GGPP) are synthesized.  M. tuberculosis does not synthesize (2E,6E,10Z)-geranylgeranyl diphosphate (EEZ-GGPP) and heptaprenyl diphosphate.  Can also accept many different allylic substrates, including E-geranyl diphosphate (E-GPP), neryl diphosphate (NPP), and all-trans-geranyl-geranyl diphosphate.
What are the official names of this protein?
Decaprenyl diphosphate synthase, DecaPP, Decaprenyl pyrophosphate synthase, Long-chain isoprenyl diphosphate synthase, Trans,polycis-decaprenyl diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: ZUPT_ECOHS
Sequence: MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSVMGFSLVLLQTAGIG
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KUP1_LEGPH
Sequence: MKKNRFTYGLALGALGVVFGDIGTSPLYALKVTLSGIPINQFNILGVLSLIFWSLIIIVSFKYLMIIFRADNDGEGGILALLALMKHKSTKYQPLFYIVAIFGAGLLLGDGMLTPAISVVSAVEGLGTLSDKLYPYVLPIASVILVLLFSLQAKGTARIGYLFGPLILIWFITIAILGILQIVEHPVVLQAINPYHAIAFLVDEGLRGYFLLGGIFLVVTGGEALFADIGHFGKNPIRFSWFFIALPCLLLNYFGQGANLIVRPEEISNPFFMIAPPWFYLPLIIIATVATVIASQAVISATFSLTKQAVLLGLCPKIPIVQTSMLHSGQIYVPQINFILFIGTMAFCLAFKTSDNLAHAYGIAVNLEMLLVDAMVAYAAVSIWRWSTFNVIFLFGLFLLIDLAFLGANTHKFITGGWVPIVLAFFIAFIMYSWRYGLEYLRDNFYMNKEDISKILKQLQYKSLNQLPGVSAIFITDVYDKSGGSFLHFLKLNRSVPENVLIVNYIVDNIPYVHYSQRYEIVCLDEKVCKLVIHYGFMETINIPRSLEKACNKNILPFKFNVDTATFMVEIPNIMASKEKRSLSFYWQEKLFAFLMRNYSANLNIEFYKLPYNRTIAIGTYCIL
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 1.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: H2B_PATGR
Sequence: MPPKVSSKGAKKAGKAKAARSGDKKRKRRRKESYSIYIYKVLKQVHPDTGVSSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B, gonadal.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: YL396_MIMIV
Sequence: MANNIKTKITRFGYIVNKNLIDDETIKEIKSDLTVVPFKINNYAPKYIKNEGFPLYVENGNYIGIPKYYGFDKLGEPDIDKVSNYEYPVQDMTYTGTLRPHQQMVSDKIIKGMEEGGGGVLVMGCGSGKTNVAIYIACKFKLRTLFVVHKTFLRDQVIDRIKSNTNVKKVGIIQRKIVNYKHPFVVSMVQSLAKINYNDEIFKDFGMIIIDEVHHMGARNFSTVYQKISSKYMLGISAEYTRTDGMYKIINWYMGPILHLEEQKPNEMVIVKQFYYSTSNKERIKMKYINGDTNKPNRSKMITNLFYIKRRNRFILYLIQELFDMGKNILFLSGRLKQIDLLYELLNNDEFTHGNVGKYIGGMKESSLKKSAMKQIILGSYDMASEGLDIEGLNVVILGTPKTSIKQSVGRILRKEVYEEHPIVIDIVDVDNDTFKKQSKSRNNYFQKQKYNIQKYYISESLKQKYELWNDKEYIKKVLVEIPEIPDKQTQDMIKTNPNPKKKYQGPINIDELNFLEDD
What are the official names of this protein?
Putative ATP-dependent RNA helicase L396.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
Protein: PRIM_PSHV1
Sequence: MFGFLIGVFFDRREESKCEPLVKHAPAIEPEASEAENYPLSSSADDKILAEALDAVETTILGSGSCLHVTDTAAMPPAGDSAAAAVMMGSHSPGDRLMIEALESVEASRGLTHSADTCSQRCSIALSAPQSPQSRVPEGPIMDSGQIFAVSGAGEEENWIDDEDMALCAADLQIDPIGDAQSVGGSTAACLPPSQKEEIRILYATDGYPVVCSLHLLLGQALLQELYVIAYSHVTEPSAHGGGLLRATFYLLAATGCERQRQRVRPVFVCSFTGEAADKTREALREGKPLMVQDVIASLDEAQSLALHEDLIIALGTICSAGKTAAAPGGDERNLSYNYVASTLPGLRRTLASLMLQYETRVVAAFRRKYNASFSCPFWFVSKFGPSETSLVAVLRYYLLGATQDDGIAGSFDLQGVKDLAVTFPKPGANASGLTAARLNTFAEFSRFWCCSELAGPKAEKLFREYLKTRVSSDTLYVQSLDSLIEKYRHALRLPAKDFVRFVYLAYHEGYNRAAVEAHMEEALRNGGRAETAATRAQSEFFKGLREMCSMPEYFARNVDVAVKRLPVRVAEEHARLRSYGEIPRSGFWGFCWPSYDVSLRINKICAGPLCCLGTQLADAMVRAPPDDGDKGTCAETAATIIHHDSDASGEEEATVKVCGAHMPRANKRAGDGTRISPACNEADTRAPLARLTALAYSDQRPRGIMPVTLLLYSLDDTSSGADTAVKSEAKAQDRPVPVYRVAMPGGGQAFAVVARDQWDKTVTVDVFSGFMAPKSPPESNGPLGSDKDAAAVDDAWTRALLARAWGTSYARRCAANVGASQLYLNRNEVLSDSLAVCNLPLDLDITLKPSSVGRPSMLTLHMAMRSVREAIVLLWSLLFADAEIDPDTYPVYFYKTQCDAAAGDEEASPQRRGVGGGDDDVAWGEEDVEIEEMWGGYYSQTAMNDDMIWDDAPDPQMDIDSDHPAHEPMDDGAGAAIEEMKTAAAARFCRCERKIGFRICVPIPKPYALAGLSVAKATSALVQQAIVLQEKFVEALDQFIADYEFVDSGVYSAGRSLRLPFFAKVNARGVMVGRLLPFLVFPPKCRDRSEFVAQHADPNNFHVGAARRDNPAPTLIITSVTVRRDVLAQDNRAHGKPRAGTARLADALAAVGIVPGNQQGTPGDACAVDASWLLDSVAMPALREYIDEHFPRHAAEYRDARTDCIRVYEGRICAALRRGGAGYMSGRRSNFTCLKYQHRGASMQTVIASVVVAVNSQGLPYAALQTRCFATKCGSNELQTQFTVTLSATKDV
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Protein: ISPF_HAHCH
Sequence: MSLFRIGHGFDVHAFSETGDLIVIGGVNIPHERGLQAHSDGDVLLHAICDALLGAAAFGDIGKHFPDTDPSFSGADSRNLLRSVVSKLHQKGYKIGNIDGTIVAQAPKMAPHIESMRVNIASDCNVSIDCINVKATTTEKLGYTGRKEGIACHAVALLEAQKN
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: HIS5_NATPD
Sequence: MDTTDRTAEVVLVDYGLGNLRSVTRGLERAGAEVTLSADPDDFSAADGIVLPGVGAFSEGMENAGPFREALVAAAADGQPLFGICLGMQMLLTSSEEAETVGQGDVRGLDLVPGRNVRFDEGQKVPHMGWNELNVARDHPIVEGIDGEYAYFVHSYYAAPDDDAAVVATTDYSVEFPAIVANEAGNVFGTQFHPEKSGETGLQILQNFVDYCLER
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_ANAPZ
Sequence: MKTLDLYGYTSIAQSFDKICISIASPESIRAMSYGEIKDISTTNYRTFKVEKGGLFCPKIFGPVNDDECLCGKYRKKRYRGIVCEKCGVEVTSSKVRRERMGHIELVSPVAHIWFLKSLPSRIGALLDMPLKAIENILYSGDFVVIDPVATPFAKGEVISEVVYNQARDAYGEDGFFALTGVEAIKELLTRLDLEAIRATLRNELESTSSEMKRKKVVKRLRLVENFIKSGNRPEWMILTVIPVLPPDLRPLVSLENGRPAVSDLNHHYRTIINRNNRLEKLLKLNPPAIMIRNEKRMLQEAVDALFDSSRRSYVSSRVGSMGYKKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPSLKLHQCGLPKKMALELFKPFICSKLKMYGIAPTVKLANKMIQSEKPDVWDVLDEVIKEHPILLNRAPTLHRLGLQAFDPVLIEGKAIQLHPLVCSAFNADFDGDQMAVHVPLSQEAQLEARVLMMSTNNILSPSNGRPIIVPSKDIVLGIYYLTLLEEDPEVREVQTFAEFSHVEYALHEGIVHTCSRIKYRMQKSAADGTVSSEIVETTPGRLILWQIFPQHKDLTFDLINQVLTVKEITSIVDLVYRSCGQRETVEFSDKLMYLGFKYASQSGISFGCKDMIIPDTKAAHVEDASEKIREFSIQYQDGLITKSERYNKVVDEWSKCTDLIARDMMKAISLCDEKGKYNSIYMMANSGARGSASQMKQLAGMRGLMAKPSGEIIETPIISNFREGLSVFEYFNSTHGARKGLADTALKTANSGYLTRRLVDVAQDCTVVEHDCGTSGGVVARAVIEGGVVVATLDSVVLGRVAAVDTYNPVTGEKLFTSGELIDESKLDKIRVAGLDAVKVRSPLTCESKQGICALCYGRDLAIGDLVSIGEAVGVIAAQSVGEPGTQLTMRTFHVGGTAMRGVEVSNLIALMDATVKLVNSNVVTDKYGNQIVMSRSCEVVLLDAAGNEKMRHSVPYGAKLYATEGQSVSMMEKIAEWDPYTIPIITEKTGTIKYVDLIYGVSINEVLDESTGISNRVVVDWKMHLQGANLRPRLVLLDDNGAVVTLSSDLEASYFVPIGAVLNVQDGQRVHAGDVITRIPRGSIKTRDITGGLPRVIELFEARKPKEHAIVSDVDGYVEFGKDYYRSKRRIFIRPVDKSLPVVEYLVPKGKHTIVNEGDFVHKGDLLMDGDPDQHDILRVLGTEALANYMISEIQQVYRLQGVKIDNKHIEVILRQMLQKVEITEPGDTMYLIGEHVSREEVMKLNRKLAEAGKKEVSYVPILQGITKASLDTNSFISAASFQETTKVLTEAAFAGKEDPLYGLKENVIVGRLIPAGTGFIMNKIKKLAMLDQSDYATYYNSELRGIMGDLGSSIIEEFQTPAPDGSISGSVVDY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: 1A1D_RHIRD
Sequence: MLEKFERYPLTFGATAIEYLPRLTEALGGDVEIWAKREDCNSGLAMGGNKLRKLEYIVPDAIASNADTLVSIGGVQSNHTRMVAAVAAKLGMKCRLVQESWVPHEDAVYDRVGNILMTRLMGADSRIVDDGFDIGIRQSWEDAIQSVIDEGGKPYAIPAGASVHKYGGLGYVAFAEEVARQEADLGFKFDYIIVCVVTGSTQAGMIVGFAAQDRADRVIGIDASGTPEQTRSQVRQIVDNTAELVELGRPVREDEIVILNDYAYPAYGVPSNETNEAIRLAARTEAMITDPVYEGKSMQGMIDLTRKGFFPKGSKVLYAHLGGAPALNGYSYTYRNG
What is the function of this protein?
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate.  Allows growth on ACC as a nitrogen source.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate deaminase, ACC deaminase, ACCD.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: PETL_PINKO
Sequence: MPTITIISYFGFLLASIIFTLVLFISLSKIQLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.