PharMolix/UniProtQA huggingface dataset:
Protein: RS21_HAEI8
Sequence: MPVIKVRENESFDVALRRFKRSCEKAGILAEVRAREFYEKPTTIRKRENATLAKRHAKRNARENARNTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: DXR_ALIFM
Sequence: MRKLTILGATGSIGSSTLSVAQQNSDQFEIVALGAGTNVDKMLELCLEWKPKYVAMATQPAADALKELLSAHAINAEVFSGEDGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKASKRILLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCLPQSIQTNLGRCDLEEHGVSSILLTGSGGPFRYTDVSELEAVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFNASKEQLKVVIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPKRVNAGVEPLDFTKVGEFTFIAPDFSRYPCLKLAIDACYLGQHATTGLNAANEQAVAAFLANKIKFTDIARINEAVLHKVCANFQNLELDSLESLIDLDRMARRYADEAINKV
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: CRR47_ARATH
Sequence: MSSVFGSVHILAMIAIQLLLTHSVSSLNLTNAYLHHKCSNTQGKYKQGSAFEKNLNLVLSTITSIGNFRDGFRYTEEGEDPNNVFVMFQCRGDSYWSKCPPCISTAVSGLRRRCPRNKGAIIWYDQCLLKISSVASFNKIDYENDFYLSNPNNMSDRGLFNKETSALLEKLAYKASDRNNLDGKQLVLYAAGEKRIGTKKVYAMVQCTKDLIFTKCFECLEGILRKFPQCCDGKRGGRVFGTSCNFRYELYPFLRN
What are the official names of this protein?
Cysteine-rich repeat secretory protein 47.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS9_ACTP7
Sequence: MTAANQNYGTGRRKSSSARVFIKPGNGNITINQRSLDVYFGRETSRMVVRQPLELVELLDKLDLYITVKGGGISGQAGAIRHGITRALMEYDETLRPALRAAGFVTRDARRVERKKVGLHKARRRPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: GBRE_RAT
Sequence: MLPKVLLMLLNMFLALQWRVGPHIKLENKPPAQDKVVFGPQPQPSGKKLPARETELTADHTTERPRGKLTRASQILNTILSNYDHKLRPSIGEKPTVVTVKVFVNSLGPISILDMEYSIDIIFYQTWYDERLRYNDTFETLILHGNVVSQLWIPDTFFRNSKRTQEYDITIPNQMALIHKDGKVLYTVRMTIDARCSLHMLNFPMDSHSCPLSFSSFSYDEHEMIYKWENFKLKIDAKNTWKLLEFDFTGVNNKTEIISTPVGDFMVMTFFFNVSRRFGFIVFQNYIPSSVTTMLSWVSFWIKIEAAAARASVGVSSVLTMATLGTFSRKNFPRVSYLTALDFYIAICFVLCFCTLLEFTVLNFLTYNNIERQASPKFYQFPTNSRANARTRARARTRARARARARQQQEVFVCEIVTYEENAEEGYQWSPRSRRPQCPWRRCGRSYVCFRVLRKYFCMVPGCEGNNWQRGRICIHVYRLDNYSRVLFPITFFFFNVVYWVICLNL
What is the function of this protein?
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit epsilon, GABA(A) receptor subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: YEII_ECOLI
Sequence: MNNREKEILAILRRNPLIQQNEIADMLQISRSRVAAHIMDLMRKGRIKGKGYILTEQEYCVVVGTINMDIRGMADIRYPQSASHPGTIHCSAGGVGRNIAHNLALLGRDVHLLSVIGDDFYGEMLLEETRRAGVNVSGCVRLHGQSTSTYLAIANRDDQTVLAINDTHLLEQLTPQLLNGSRDLLRHAGVVLADCNLTAEALEWVFTLADEIPVFVDTVSEFKAGKIKHWLAHIHTLKPTLPELEILWGQAITSDADRNTAVNALHQQGVQQLFVYLPDESVYCSEKDGEQFLLTAPAHTTVDSFGADDGFMAGLVYSFLEGYSFRDSARFAVACAAISRASGSLNNPTLSADNALSLVPMV
What are the official names of this protein?
Uncharacterized sugar kinase YeiI.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: ILVC_XYLFT
Sequence: MVNVSITTDYSRMLFMRNTKSTLKIAIIGYGSQGRAHALNLRDSGFDIIVGLRPGGATEAKAQADGFTVQSPDQAAKHADLVAVLTPDMVQKKLYEEVLAPNIKQGACLLFAHGLNVHYSLITPRSDLDVVLVAPKGPGALVRREYEIGRGVPCIYAVHQDLSSHAEQLALTYAGGLGGARANIIKTTFKEETETDLFGEQAVLCGGVSSLVQAGFETLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFVSETAQYGDYVSGPRVIDRSTKERMKAVLKDIQDGTFTKHWIAEYQAGLPNYKKYKQADLEHPIEKVGKQLRAKMVWLNSEKTNDTTHPMSSKVV
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ARRA_SHESA
Sequence: MKKENQVNLGRRQLLKSTAAGTVLTGIGGTLSFTPIVEGIAAELPAPLRRTGVGEWLATTCQGCTSWCAKQIYVMDGRALKVRGNPNSGVHGMSSCPRQHLSLQQVYDPDRLRTPMMRTNPKKGRDQDPKFVPISWDKALDMLADKIIALRVANEPHKYALLRGRYSHINDLLYKKMTNLIGSPNNISHSSVCAEAHKMGPYYLDGNWGYNQYDVKNAKFILSFGADPIASNRQVSFYSQTWGDSLDHAKVVVVDPRLSASAAKAHKWIPIEPGQDSVLALAIAHVALVEGVWHKPFVGDFIEGKNLFKAGKTVSVESFKETHTYGLVEWWNQALKDYTPEWASKITGIDPKTIIAIAKDMGAAAPAVQVWTSRGAVMQARGTYTSISCHALNGLFGGIDSKGGLFPGNKTPLLKEYPEAKAYMDEIAAKGVKKEKIDQRGRLEFPALAKGKSGGGVITANAANGIRNQDPYEIKVMLAYFNNFNFSNPEGQRWDEALSKVDFMAHITTNVSEFSWFADVLLPSSHHMFEKWGVLDSIGNGVAQISIQQPSIKRLWDTRIDESEIPYMLAKKLADKGFDAPWRYINEQIVDPETGKPAADEAEFAKLMVRYLTAPLWKEDASKYGDKLSSWDEFVQKGVWNSSPYKLEARWGKFKTETTKFEFYSKTLEKALQSHADKHKVSIDEVMKACDYQARGHLAFIPHYEEPYRFGDESEFPLLLVDQKSRLNKEGRTANSPWYYEFKDVDPGDVANEDVAKFNPIDGKKFGLKDGDEIRITSPVGMLTCKAKLWEGVRPGTVAKCFGQGHWAYGRYASAKFGVTPRGGSNNDLIADRYDRLSGASAFYGHIRVRVEKV
What is the function of this protein?
Component of the arsenate respiratory reductase (Arr) complex, which catalyzes the reduction of arsenate (As(V)) to arsenite (As(III)) (PubMed:12939408, PubMed:17951391, PubMed:30104376).  ArrA is the arsenate-binding subunit (PubMed:30104376).  The periplasmic localization of this complex may allow the cell to couple arsenate reduction to energy production before arsenate can be transported to the cell cytoplasm and enter the ars detoxification pathway, an energy-requiring process (PubMed:17951391).
What are the official names of this protein?
Arsenate respiratory reductase molybdopterin-containing subunit ArrA, Arsenate respiratory reductase large subunit, ARR large subunit.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YACL_SALPK
Sequence: MDYEFLRDVTGRVLVRMSMGHEVVGHWFNEEVKDNLSLLDEVEQAARTVKGSERSWQRAGHEYTIWIDGEEVMIRANQLDFSGDEMEEGMSYYDEESLSLCGMEDFLRVVAAYREFVSKA
What are the official names of this protein?
UPF0231 protein YacL.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: RRF_TREDE
Sequence: MIEEVKKNCEEKMKKTVVALKEEFNMLRTGRASSALFDKIRVNCYGESTPLNQLANISIPEARLVVIQPWDKGLLVEIEKAVLQADLSVNPTNDGKVIRIAIPPLTEDRRKDLAKKAKTIAENSRVSVRNIRRDGIDEAKKLQKDGKISEDQLKTAEDAFQKSTDAYIAEINKVLEAKEKEIMEN
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_XYLF2
Sequence: MNPAPNLVMIGPMGAGKSSIGRRIAKHFNLHFADTDHAIVERAGTSISTIFKYSGEPEFRRLEREVLYDLLNHENRLIATGGGTILDPENRHRMQKRGFVVFLKINVNTQLERLAHDRYRPLLQQIDRKQVLSDLYATRQPLYQKIADMIVTTDHMSPNTATAQLILDLTAHWQKSSNTA
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_MYCGA
Sequence: MGQKVNSNGLRFGINKNWQSRWVAKTNQQTGDWIVQDEKIRNYLFKKFHSAFISNVDIERTQTSIRVFIYASQPGIILGKEAANIKVILLAINKIVGRHIKVDVDVLEVGNPSLSAKIVARELADAIENRTPLRTAMRQALKRVLKAGAKGIKVLVSGRLNGVEIARDKMYIEGNVTLSTLRTDIDYALEEAQMSYGVIGVKVWINRGEIFGKDFYKKQAHIVKPKGSEANHQRRNSNKSKDYRDNKNKQFNKNHQNQQPAKE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: Y066_METJA
Sequence: MWEVIIMKTYIGKIHLKWCKNCNVPLLGRVCEVCGSKAEEVKLTPPGDPRLGFQYDMDFINKILEEEFGAKNVLNGKIILLNKIPGNEEAYEIIVDGEVKYLIYFDEDKEKWKVKLKLNGAKDLMEKGAYKKIIKIKNDVVEFLKNRKGSVLRPGIVEFTDDIEEKDDVIIVDENDRVVGVGLAVVSSEDIKNMEKGKVVKVRFFIKDNEDYKPGKIYDNLEEAFDLMVRANEGVIDNYERNAIGFIKNTYEKIKKPVMVAFSGGKDSLVTLILTLKALGKDIDVVFIDTGLEFEETLKNVEDVERHYGIKIIRLRGENFWEKVKEYGIPARDYRWCSEICKLEPLKKFIEENYEDDVLSFVGIRKYESFNRATKKRIHRNTYIKKQINALPIFHWSSLHVWIYLLREKAPYNKLYEKGFDRIGCFMCPAMEMGEMNKIKREFPKLWEKWENVLREYAEKHNLGEGWIKKGLWRWKHKRQ
What are the official names of this protein?
Uncharacterized protein MJ0066.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PAPS reductase family.
Protein: FBX43_XENLA
Sequence: MANLLENFAAHHSMTAGAKKKADHQDTSVSQDSGYSDSLKGFSPDSHKSGNFLETVTEGYENSENIDPTLILSPIKYELSWGADTRESKQLAPLYETPRVGKKEFSLRRRLLISKATSGGNLDFDVSVCSAESCGREKSLRRIPSHEGSLSNSFADSPRDGSYEPIATSTLKTESESGTSCKKWRLSFAQQRSSTLDDSKSDSIPLPEVENISPVQHSLASSTDDSILYEETIFGAPTTPTCNFIVKEEFQTPISNLAANFRFNLCTPDVGHVSDFDISVTEDSAFHSLSLDKSQDSITDHEGSFQELIQKPRETSKAVNNKSRLRKLDRCRRLSTLRERGSQSEVEEEGNEVPVLSSAYKLKVARASVDEENEFSSDESRVHSLLSSDDLTGKPALRVLHEMLLRSTRKRPQQATVQDLLGSSGCFELPEDSLSRLIGRKMGLETFDILAELKNRNLKHILASILDLVNAASICSMCRVSRDWRDVVLQDKSAHQRRKAYIKKLKTEAEQGRQLSFEDSATRLNILSRSALRSVQIQARSAFRTPTSSLTPGDNKSIHSASKHQEYLKVAKTLFTDEALKPCPRCQYPAKYQALKKRGTCSRKDCGFDFCSLCLCTFHGSKECGTGSAKRIPKKEALPGSAQSKRNLKRL
What is the function of this protein?
Required to prevent anaphase onset in cytostatic factor-arrested oocytes.  Inhibits the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase and prevents cyclin degradation.  Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
What are the official names of this protein?
F-box only protein 43, Early mitotic inhibitor 2, Emi1-related protein 1, F-box protein 26, Xerp1.
Protein: TET5B_HUMAN
Sequence: MMPSESGAERRDRAAAQVGTAAATAVATAAPAGGGPDPEALSAFPGRHLSGLSWPQVKRLDALLSEPIPIHGRGNFPTLSVQPRQIVQVVRSTLEEQGLHVHSVRLHGSAASHVLHPESGLGYKDLDLVFRVDLRSEASFQLTKAVVLACLLDFLPAGVSRAKITPLTLKEAYVQKLVKVCTDSDRWSLISLSNKSGKNVELKFVDSVRRQFEFSIDSFQIILDSLLLFGQCSSTPMSEAFHPTVTGESLYGDFTEALEHLRHRVIATRSPEEIRGGGLLKYCHLLVRGFRPRPSTDVRALQRYMCSRFFIDFPDLVEQRRTLERYLEAHFGGADAARRYACLVTLHRVVNESTVCLMNHERRQTLDLIAALALQALAEQGPAATAALAWRPPGTDGVVPATVNYYVTPVQPLLAHAYPTWLPCN
What is the function of this protein?
Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner (PubMed:32009146, PubMed:34048638).  May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs (PubMed:32009146).  Prefers RNA molecules that are adenosine-rich close to 3'-end (PubMed:32009146).  In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1 (PubMed:30532005).
What are the official names of this protein?
Terminal nucleotidyltransferase 5B, Non-canonical poly(A) polymerase FAM46B.
What is the protein family that this protein belongs to?
Belongs to the TENT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: UL24_HHV2H
Sequence: MARTGRRAAVGRPARTSSLTERRRVLLAGVRSHTRFYKAFAREVREFNATRICGTLLTLMSGSLQGRSLFEATRVTLICEVDLGPRRPDCICVFEFANDKTLGGVCVILELKTCKSISSGDTASKREQRTTGMKQLRHSLKLLQSLAPPGDKVVYLCPILVFVAQRTLRVSRVTRLVPQKISGNITAAVRMLQSLSTYAVPPEPQTRRSRRRVAATARPQRPPSPTRDPEGTAGHPAPPESDPPSPGVVGVAAEGGGVLQKIAALFCVPVAAKSRPRTKTE
What is the function of this protein?
May participate in nuclear egress of viral particles.  Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1.  Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli (By similarity).
What are the official names of this protein?
Protein UL24.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL24 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus, host nucleolus. Host Golgi apparatus.
Protein: MTNN_VIBVY
Sequence: MKVGIIGAMQQEVAILKEAMTNAQTVNKAGCTFYSGQINGVEVVLLQSGIGKVAAAIGTTILLDEYQPDMVLNTGSAGGFDSSLNLGDVVISTEVRHHDADVTAFGYEMGQMAGQPAAFLADEKLMNLAEKALEQMDGQHAVRGLICTGDAFVCTAERQAFIRQHFPSVIAVEMEASAIAQTCHQFKVPFVVVRAISDVADKESPMSFEEFLPLAAKSSSEMVFKMLELLK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: NSE1_RAT
Sequence: MQGSTRRAGAMTDVHRRFLQLLMTHGVLEEWEVRRLQNHCYKVHDRNATVDKLEDFINNINSVLESLYIEIKKGITEDDGRPIYALVNLATTSVSKMATDFAENELDLFRKALELIVDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQSKWLIEKEGEFTLHGRAILEMEQFIRESYPDAVKMCNICHSLLIQGQSCETCGIRMHLPCVAKYFQSTAEPRCPHCNDYWPHDIPEVFDPEKEREAGISKSSRKSLRTRQH
What is the function of this protein?
RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate.  Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex.  Involved in maintenance of genome integrity, DNA damage response and DNA repair.  NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair.
What are the official names of this protein?
Non-structural maintenance of chromosomes element 1 homolog, Non-SMC element 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the NSE1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RHAA_SALAR
Sequence: MTTQLEQAWELAKQRFAAVGIDVEEALRQLDRLPVSMHCWQGDDVAGFENPEGSLTGGIQATGNYPGKARNATELRADLEKALSLIPGPKRLNLHAIYLESDTPVARDQIKPEHFKNWVAWAKAHKLGLDFNPSCFSHPLSADGFTLAHADDNIRQFWIDHCKASRRVSAYFGEQLGTPSVMNIWIPDGMKDITVDRLAPRQRLLEALDEVISEKFDPAHHIDAVESKLFGIGAESYTVGSNEFYMGYAASRQTALCLDAGHFHPTEVISDKISAAMLYVPRLLLHVSRPVRWDSDHVVLLDDETQAIASEIVRHNLFDRVHIGLDFFDASINRIAAWVIGTRNMKKALLRALLEPTDQLRQLEASGDYTARLALLEEQKSLPWQAVWEMYCQRHDTPTGSQWLESVRAYEKEILSKRR
What is the function of this protein?
Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
What are the official names of this protein?
L-rhamnose isomerase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIFA_XENTR
Sequence: MDETLNVDTEQTLTCLTLTMYHPNHQDQKLFRGINFSRKEEIKADAVVAFGRDYNVCRYPLLSNRVSRIQFNLQFFKHFNCSTTAIEIKNLSKKNKLYVDNLELDYLNKIELPPKCMIRFGDFQILAVIERGDCDEKFEICCEKSHVSLVQDSFIPTMQPIPECGTLNAVEIDENEY
What is the function of this protein?
Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (By similarity).  Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity).
What are the official names of this protein?
TRAF-interacting protein with FHA domain-containing protein A.
What is the protein family that this protein belongs to?
Belongs to the TIFA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EUTP_ECOLI
Sequence: MKRIAFVGSVGAGKTTLFNALQGNYTLARKTQAVEFNDKGDIDTPGEYFNHPRWYHALITTLQDVDMLIYVHGANDPESRLPAGLLDIGVSKRQIAVISKTDMPDADVAATRKLLLETGFEEPMFELNSHDPQSVQQLVDYLASLTKQEEAGEKTHHSE
What is the function of this protein?
A putative bidirectional acetate kinase that may drive flux through the ethanolamine degradation pathway under anoxic conditions.  It may generate ATP that can be used by other enzymes (EutA and EutT) in the eut pathway.
What are the official names of this protein?
Probable acetate kinase EutP, Ethanolamine utilization protein EutP.
What is the protein family that this protein belongs to?
Belongs to the EutP/PduV family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: RBS_BETPN
Sequence: MACSMISSATVAAVSRASPAQSSMVAPFTCLKSTSAFPVTQKTNNDITSIASNGGRVQCMQVWPPLGLKKFETLSYLPPLSSEQLAKEVDYLLRKNLIPCLEFELEHGFVYREHNRSPGYYDGRYWTMWKLPMFGCNDSSQVLKELEECKKAYPSAFIRIIGFDNKRQVQIISFIAYKPPGV
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YJJA_BACSU
Sequence: MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLAEKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYKTLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKGASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEVKKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE
What are the official names of this protein?
Uncharacterized protein YjjA.
Protein: HEM3_ECO8A
Sequence: MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDTRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQNAEQMGISLAEELLNNGAREILAEVYNGDAPA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: MRGRE_MOUSE
Sequence: MTSLSVHTDSPSTQGEMAFNLTILSLTELLSLGGLLGNGVALWLLNQNVYRNPFSIYLLDVACADLIFLCCHMVAIIPELLQDQLNFPEFVHISLTMLRFFCYIVGLSLLAAISTEQCLATLFPAWYLCRRPRYLTTCVCALIWVLCLLLDLLLSGACTQFFGAPSYHLCDMLWLVVAVLLAALCCTMCVTSLLLLLRVERGPERHQPRGFPTLVLLAVLLFLFCGLPFGIFWLSKNLSWHIPLYFYHFSFFMASVHSAAKPAIYFFLGSTPGQRFREPLRLVLQRALGDEAELGAGREASQGGLVDMTV
What is the function of this protein?
Orphan receptor.  May regulate nociceptor function and/or development, including the sensation or modulation of pain.
What are the official names of this protein?
Mas-related G-protein coupled receptor member E, Evolutionary breakpoint transcript 3 protein.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1723_PASMU
Sequence: MSSYSDFSQQLKTAGIALSAAELHGFLTGLICGGIHDQSWQPLLFQFTNENHAYPTALLQEVTQIQQHISKKLADIDGFDFELWLPENEDDVFTRADALSEWTNHFLLGLGLAQPKLDKEKGDIGEAIDDLHDICQLGYDESDDKEELSEALEEIIEYVRTLACLLFTHFQPQLPEQKPVLH
What are the official names of this protein?
UPF0149 protein PM1723.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: UBP1_RAT
Sequence: MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQEDEEKASEYRGSEIDQVVPAAQSSPVSCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKAGVKHLFNIISRKKEALKDDSIQKDKGSCKEDPLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEIKNLTEFSSKVEEKSLQKEETGGISSTETDSTRNLDDLKEQLPKGNWKRKSDGESGNMKKKVKLSRESQPLEENQRQTRSKRKATGDTLEASPKIIPKCVSENESAKPSQKKSKVKINWLKPATKQPSILSKFCSLGKITTNQRSKGQPKVNEGDLEEDLEKDGRDNTVNGSGPASPGSSVTPVDSSEAKSINKGAEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGTAENYDDEVSIRVGGNAQPSKVLNKKNVEGIGLLGGQKSKADYELCSKASNPEKVVGTPFTDSRNSETNDTNGTQESDRSKESSDQTGINVSGLENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL
What is the function of this protein?
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2.  Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA.  Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 1, Deubiquitinating enzyme 1, Ubiquitin thioesterase 1, Ubiquitin-specific-processing protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYSD_ECO27
Sequence: MDQKRLTHLRQLEAESIHIIREVAAEFSNPVMLYSIGKDSSVMLHLARKAFYPGTLPFPLLHVDTGWKFREMYEFRDRTAKAYGCELLVHKNPEGVAMGINPFVHGSAKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINKGESIRVFPLSNWTEQDIWQYIWLENIDIVPLYLAAERPVLERDGMLMMIDDNRIDLQPGEVIKKRMVRFRTLGCWPLTGAVESNAQTLPEIIEEMLVSTTSERQGRVIDRDQAGSMELKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.