PharMolix/UniProtQA huggingface dataset:
Protein: AROG_ARATH
Sequence: MVTLNASSPLTTKSFLPYRHAPRRPISFSPVFAVHSTDPKKSTQSASASVKWSLESWKSKKALQLPDYPDQKDVDSVLQTLSSFPPIVFAGEARKLEDKLGQAAMGQAFMLQGGDCAESFKEFNANNIRDTFRVLLQMGVVLMFGGQLPVIKVGRMAGQFAKPRSDPFEEKDGVKLPSYRGDNINGDAFDEKSRIPDPHRMVRAYTQSVATLNLLRAFATGGYAAMQRVSQWNLDFTQHSEQGDRYRELANRVDEALGFMGAAGLTSAHPIMTTTEFWTSHECLLLPYEQALTREDSTSGLYYDCSAHMLWVGERTRQLDGAHVEFLRGIANPLGIKVSDKMVPSELVKLIEILNPQNKPGRITVIVRMGAENMRVKLPNLIRAVRGAGQIVTWVSDPMHGNTIMAPGGLKTRSFDAIRAELRAFFDVHDQEGSFPGGVHLEMTGQNVTECVGGSRTITYNDLSSRYHTHCDPRLNASQSLELAFIIAERLRKRRLGSGNLPSSIGV
What are the official names of this protein?
Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 2, DAHP synthase 2, Phospho-2-keto-3-deoxyheptonate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II DAHP synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DPPA3_HUMAN
Sequence: MDPSQFNPTYIPGSPQMLTEENSRDDSGASQISSETLIKNLSNLTINASSESVSPLSEALLRRESVGAAVLREIEDEWLYSRRGVRTLLSVQREKMARLRYMLLGGVRTHERRPTNKEPKGVKKESRPFKCPCSFCVSNGWDPSENARIGNQDTKPLQP
What is the function of this protein?
Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:35314832).  In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process (By similarity).  Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation (By similarity).  Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark (By similarity).  Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis (By similarity).  May be important for the totipotent/pluripotent states continuing through preimplantation development (By similarity).  Also involved in chromatin condensation in oocytogenesis (By similarity).
What are the official names of this protein?
Developmental pluripotency-associated protein 3, Stella-related protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker.
Protein: CAPP_PARXL
Sequence: MKAVRSDKTTQAATTAQAQKPAKAGSSKIKIVTAAPQAANASARQPASAQAPAPKANGRTREDKDHPLFQDIRYLGRLLGDVLREQEGDAVFDVVETIRQTAVRFRREDDSAAAQTLDKKLRSLSPEQTVSVVRAFSYFSHLANIAEDRHRNRRHRIHELAGSTSQPGTIAHSLERLVEAGAAATPVLQEFFNNALIVPVLTAHPTEVQRKSILDAQHDVARLLAERDQQLTDRERAHNEAMLRARVTSLWQTRMLRDSRLSVADEIENALSYYRATFLEEIPALYADIEEALAEHGLEARLPPFFQMGSWIGGDRDGNPNVTAETLENAITRQAAVIFEHYMEQVHKLGAELSVSNLLAGASDALKELAAVSPDQSPHRTDEPYRRALIGMYTRLAASARVRLGEGSVPVRSAGRGAAPVRAKPYADSAEFVRDLHVLIDSLAEHHGAPLAAPRLSPLARAAEVFGFHLASIDLRQSSDVHEAVITELLRRAGVEENYAELPEADKLNVLLSELAQPRPLRLPFAEYSDLVKSELGVLEEARVTREKFGARAVRNYIISHTETVSDLVEVMLLQKETGLLRGCLGNANDPAQAGLMVIPLFETIPDLRNAPHIMRDLIALPGVDALIEHQGNEQEVMLGYSDSNKDGGFLTSNWELYRAELALVSLFNERGVTLRLFHGRGGTVGRGGGPTYQAILSQPPGTVDGQIRLTEQGEVIASKFGNPEIGRRNLETVVAATLEASLLPHGIAPAQLPAFEETMQQLSDAAMASYRALVYETPGFKEYFFESTPISEIAELNIGSRPASRKLQDPKQRKIEDLRAIPWGFSWGQCRLLLTGWYGFGSAVAAHLDSAPSDAERTRRLALLKKMHKTWPFFANLLSNMDMVLAKTDLAVASRYAALVSDKKLRKHVFERIVAEWERTSKVLSEITGKSERLAENPLLARSIKNRFPYLDPLNHLQVELLKRHRAGDTNARVRRGIHLSINGIAAGLRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: MSCL_BRUMB
Sequence: MLKEFQEFALKGNMVDLAIGVIIGGAFGGLVNSIVNDIIMPIIGLITGGIDFSNMFIQLAGDPKTTLAAAREAGATIAYGNFITLLINFLIIAWVLFLVVKLMNRLKKREEAKPAPAAPSEEVLLTEIRDILAKQQKA
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YM9D_YEAST
Sequence: MHGTCLSGLYPVPFTHKAHDYPHFNIYISFSGPKYCITALNTCVIPLLHHILTTQCITLMLILQKIQHQNHLNIKIIIFQLYKINILTCGHYPLNSIPFTVT
What are the official names of this protein?
Putative UPF0320 protein YMR326C.
What is the protein family that this protein belongs to?
Belongs to the UPF0320 family.
Protein: AROC_HAEI8
Sequence: MAGNTIGQLFRVTTFGESHGIALGCIVDGVPPNLELSEQDIQPDLDRRKPGTSRYTTPRREDDEVQILSGVFEGKTTGTSIGMIIKNADQRSQDYGEIKDRFRPGHADFTYQQKYGIRDYRGGGRSSARETAMRVAAGAIAKKYLREHFGIEVRGFLSQIGHVKISPQIIGEIDWEKVNSNPFFCPDESAVEKFDELIRELKKEGDSIGAKLTVIAENVPVGLGEPVFDRLDADLAHALMGINAVKGVEIGDGFAVVEQRGSEHRDEMTPNGFESNHAGGILGGISSGQPIIATIALKPTSSITISGRSINLNGEPVEVVTKGRHDPCVGIRAVPIAEAMMAIVLLDHLLRFKAQCK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: URED_HALH5
Sequence: MRASSHLPQLHGRLDLTFERRRGTTRLVASEQTPPLNVSRVLRTEEVDLATVYLVETSGGVVSGDSQTIAIYVGEGARVELIPQSATKVYPSRKQGESSTQQVWLRVDEGAAAFWKPESIIPFRKASFLQSTRFHLHSSSTFFYGDMLTPGRVHHNERFQYEQVDSLVEIYLDETLVVHDRVHLQPKDQLQTIGRLDGYSYYGAVWMHAPILKGAHLEQWMENGGQNDRFAYTCVAEGLIHVRWLSESSWRLRAALNDLYTAFRTFALKGE
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
Protein: SYT_BARHE
Sequence: MSCSVSLSFPDGSKRDYHSEMTGLELAESISKSLAKKALAYSLNGIIRDLSDPIKQSGQIEIITREDTRALELIRHDCAHVLAEAVQELFPGTQVTIGPVIENGFYYDFARQQPFTLDDLTIIEKKMREIIQRNKPFRKEVWSRKKAREIFSEKGELYKVELIDSIPDNQDLKVYYQGDWFDLCRGPHMQSTGQIGNAFKLMKVAGAYWRGDANNPMLTRIYGTAFANENDLKAYLHMLEEAEKRDHRRLGREMNLFHFQEEGPGMIFWHKKGWKMFQNLINYMRRRLDDHQYAEVNAPQVLDRSLWEISGHWEWYKENMFKAIPAAEDWDNENVYALKPMNCPGHVQIFKHGLKSYRDLPTRIAEFGVVHRYEPSGSLHGLMRVRCFTQDDAHIFCTDEQLADECLNINDLILSTYADFGFKEISLKLSTRPEKRVGSDALWDHAENIMESVLKTIETKSAGQIKTSILPGEGAFYGPKFEYTLKDAIGREWQCGTTQLDFNLPERFNAFYIDKDSEKRQPVMIHRAIFGSMERFLGILIENFSGHMPLWFAPEQIVVATITSEANEYAKKLTAKLKSVGLSTTLDLRNEKINYKIREHSLQKVPVILVCGKRESETNSVNMRRLGSTEQIFLSVEEVIEQLKNEATPPDLRRVINA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COJA1_MOUSE
Sequence: MRHTGSWKLWTWVTTFLLPACTCLTVRDKPETTCPTLRTERYQDDRNKSELSGFDLGESFALRHAFCEGDKTCFKLGSVLLIRDTVKIFPKGLPEEYAIAVMFRVRRSTKKERWFLWKILNQQNMAQISVVIDGTKKVVEFMFRGAEGDLLNYVFKNRELRPLFDRQWHKLGIGVQSRVLSLYMDCNLIASRHTEEKNSVDFQGRTIIAARASDGKPVDIELHQLRIYCNANFLAEESCCNLSPTKCPEQDDFGSTTSSWGTSNTGKMSSYLPGKQELKDTCQCIPNKEEAGLPGTLRSIGHKGDKGEPGEHGLDGTPGLPGQKGEQGLEGIKGEIGEKGEPGAKGDSGLDGLNGQDGLKGDSGPQGPPGPKGDKGDMGPPGPPALTGSIGIQGPQGPPGKEGQRGRRGKTGPPGNPGPPGPPGPPGLQGLQQPFGGYFNKGTGEHGASGPKGEKGDTGLPGFPGSVGPKGHKGEPGEPLTKGEKGDRGEPGLLGPQGIKGEPGDPGPPGLLGSPGLKGQQGPAGSMGPRGPPGDVGLPGEHGIPGKQGVKGEKGDPGGRLGPPGLPGLKGDAGPPGISLPGKPGLDGNPGSPGPRGPKGERGLPGLHGSPGDTGPPGVGIPGRTGSQGPAGEPGIQGPRGLPGLPGTPGMPGNDGAPGKDGKPGLPGPPGDPIALPLLGDIGALLKNFCGNCQANVPGLKSIKGDDGSTGEPGKYDPAARKGDVGPRGPPGFPGREGPKGSKGERGYPGIHGEKGDEGLQGIPGLSGAPGPTGPPGLTGRTGHPGPTGAKGDKGSEGPPGKPGPPGPPGVPLNEGNGMSSLYKIQGGVNVPGYPGPPGPPGPKGDPGPVGEPGAMGLPGLEGFPGVKGDRGPAGPPGIAGISGKPGAPGPPGVPGEQGERGPIGDTGFPGPEGPSGKPGINGKDGLPGAQGIMGKPGDRGPKGERGDQGIPGDRGPQGERGKPGLTGMKGAIGPVGPAGSKGSTGPPGHQGPPGNPGIPGTPADAVSFEEIKHYINQEVLRIFEERMAVFLSQLKLPAAMLSAQAHGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGIGLPGSPGLPGSSAVGLPGSPGAPGPQGPPGPSGRCNPEDCLYPAPPPHQQAGGK
What is the function of this protein?
May act as a cross-bridge between fibrils and other extracellular matrix molecules.  Involved in skeletal myogenesis in the developing esophagus.  May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.
What are the official names of this protein?
Collagen alpha-1(XIX) chain, Collagen alpha-1(Y) chain.
What is the protein family that this protein belongs to?
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: DEF_PARD8
Sequence: MILPVFLYGQPVLRKEAEDVPKDYPDLKQLVANMFETMYNADGVGLAAPQVGLSIRLVVIDGDVMGDDFPECKGFKRALINPEFLERSEEEIAMEEGCLSLPGIHEKVSRSKTVRVRYWDENWEEHEEVVEGFAARIVQHECEHLTGHVFIDNVSAIRRQLNKGKLNSIIKGTVRCSYRAKAVGK
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: KN14F_ORYSJ
Sequence: MAEAAALFSLSAAAVVEDVLRQHGCRLSDRDLASRRAEEAAARRNEAAGWLRRTVGAVAARDLPEEPSEEEFRLGLRNGQILCGALNRVHPGAVPKACAHVVFVNLIRSRCAVCHCSVMVVVNTAADSVLQPDGAALSAFQYFENVRNFLVAAQEIGLPCFEASDLEQGGKSARVVNCVLALKSYGDWKQCGGTGPWKYGGNLKPSASGKSFVRKNSEPFRRCQSMNEGEVPYEEAGFSGDYHLDSGDMSTSRPLKMLVSAVLSDKRPDEVPQVKAALKNGTDGTKSFSKSKMDTIEVYSKHRQTKKEAYGEVTLKQYSMLQLQSKHVEELKADIRATKAGMEFMQMKYSEDINILGRHLFSLAHAASGYHIVLEENRKLYNQVQDLKGSIRVYCRVRPFLPGQVSSCAVGSIDEGNITIITPSKSGKEGRKTFSFNKVFGPSATQDEVFLDTQPLIRSVLDGYNVCIFAYGQTGSGKTYTMSGPKNMTEQTQGVNYRALSDLFKLAEQRKGAFIYDIAVQMIEIYNEQVRDLLVNDGLNKRLEIRNNSQNGLNVPDASLVCVASTMDVMELMNVGQKNRAVGATALNDRSSRSHSCLTVHVQGRDLTSGTILRGCMHLVDLAGSERVDKSEVTGERLKEAQHINKSLSALGDVIASLAQKSAHVPYRNSKLTQLLQDSLGGQAKTLMFVHISPESDALGESISTLKFAERVSTVELGAARLNKESGEVKELKEQIARLKSSLAMKDSGSEQNINRDPEAFNMKMPSPGFSNRRQGSCELVSSQTNFRQPMEDVGNIEVRANPTLRQKKPSFDLQDLLASNDSPSWPDSISRANFQMGEERVTIGGEWIDKVVVNNNNSVGDWEGDSAALPDFFYQRYHSGTRDKQYLRNNSRKKDGNEFEQQRPRFYSTNTDDSDDIDIATSDSSESDALWQFNVQSINSSISENGSKIKKPQTKLRESSDTRTPLHSQIPSASRKTSNGNRSGRQPLSGSDSRRLSSNGRHAGTK
What are the official names of this protein?
Kinesin-like protein KIN-14F.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.
Protein: YK24_SCHPO
Sequence: MNVGKKSEIQVSAKSNLNFLNELIEEKKRYEDEKRKISHQKYTDKLLEANDNETTKRKLLVKQKRKSNKEFQSNIIKKRKDEERKGTLKTEQANEEELLQRSRLELERKAKKYDQYAAGELEIKETEDDGILVDFTRKWAEEAPENETVEITDEFGRTRSVSIYETGNTLLSQKEEYKPEKPIYGDYMPSFEVDEEKVQKLWKEDEQQAVHYDSTKEVRNKGTAFYQFSFDEKEREEQLLSLKEIHAKVTQQQRKNTEDVLTLRDKKLEERRKFLERDYAIKLGERWMSEHFSNN
What are the official names of this protein?
Uncharacterized protein C140.04.
What are the subcellular locations of this protein?
Nucleus.
Protein: TENR_RAT
Sequence: MGIEGETVVLKNMLIGVNLILLGSMLKPSECRLEVTTERVQRQTVEEEGGASSYNTSSKEQPMVFNHVYNINVPLESLCSSGLEASAEQDVSAEDDTLAEYTGQTSDHESQVTFTHKINLPKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNTNCCQESAATGQLDYVPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGQCANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQEGLCICEEGYQGPDCSAVTPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPSLGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFTPKNNEGGVIAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQARGPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESDASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSPPVAPFDYYEYPIDHPSGRLDSSVVPNTVTEFTITRLYPASQYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSGPLVSGTIATNFSTLLDPPANLTASEVTRQSALISWQPPRAAIENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTIFTTGGRVFSHPQDCAQHLMNGDTLSGVYTIFLNGELSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLDNYHRITAQGRYELRVDMRDGQEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYIHRLTAGRKRRALKF
What is the function of this protein?
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components.  Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth.  Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment.  Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation.  Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth.  Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.  TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth.  The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).
What are the official names of this protein?
Tenascin-R, TN-R, Janusin, Neural recognition molecule J1-160/180, Restrictin.
What is the protein family that this protein belongs to?
Belongs to the tenascin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: SK2_RHOPR
Sequence: NSDEQFDDYGYMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-2, Rhopr-SK-2.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FLPA_SULIL
Sequence: MSEVVTVKQTNMENIYECEFNDGSFRLCTRNLVSGFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNARFFLKVNGYMLLVIKARSIDVTKDPKEIYKAEVEKLENSNFETIQIINLDPYDKDHAIVLSRYKG
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: VG57_BPMD2
Sequence: MYRGCLAIPYMRWSPWRNWSVAAIRYRRLDDGKPKYMTMPGDKPRLYNTVALTRYSRDMAITEGEIDAITAELCGIPTVGVPGAQMWKPHFRELFLGYRNVNILADGDEPGMEFAKSVAKTLPNARIIPMPEGEDVNSLVTSQGKDALLERI
What are the official names of this protein?
Gene 57 protein, Gp57.
Protein: RL19_BEII9
Sequence: MNIIETLEAEQAAKLLAKRPIPAFQPGDTVIVNVKVKEGERTRVQAYEGVCIARNGGGLNESFTVRKISYGEGVERVFPIYSPNIDSIKVVRRGKVRRAKLYYLRDRRGKAARIAEKMETPAAKAAREAAKKEAKAAAKAKKAASAAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: TM9S2_PONAB
Sequence: MSARLPVLSPPRWPRLLLLSLLLLGAVPGPRRSGGFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGKRPSENLGQVLFGERIEPSPYKFTFNKEETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPIGCYITDKGHAKDACVINSEFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKIAYTYSVSFEEDKKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIVFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATILLCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAVHYFFSKLQITGTASTILYFGYTMIMVLIFFLFTGTIGFFACFWFVTKIYSVVKVD
What is the function of this protein?
In the intracellular compartments, may function as a channel or small molecule transporter.
What are the official names of this protein?
Transmembrane 9 superfamily member 2.
What is the protein family that this protein belongs to?
Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Golgi outpost. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.
Protein: LDH_STRPG
Sequence: MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYSDCHDADLVVLTAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAAKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDIDEQGLVDLFISVRDAAYSIINKKGATFYGIAVALARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFAKEEFASAAKN
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GIMA5_MOUSE
Sequence: MEHLQKSTYGTIVQGPEAHCVQESSCLRILLVGKSGCGKSATGNSILRRPAFQSRLRGQSVTRTSQAETGTWEGRSILVVDTPPIFESKAQNQDMDKDIGDCYLLCAPGPHVLLLVTQLGRFTAEDAMAVRMVKEVFGVGVMRHMIVLFTRKEDLEEKSLEEFVTHTDNRSLRSLTQECGRRYCAFNNRASGEEQQGQLAELMALVRRLEQECEGSFHSNDLFLHAEALLREGYSVHQEAYRCYLAKVRQEVEKQRRELEEQEGSWIAKMICTVKSCWSSHTAACALLIVLGLTLLTTFINLCISRCK
What is the function of this protein?
Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (PubMed:16509771).  Inhibitor of GSK3A.  May act by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus.  Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851).  Required for the survival of bone marrow hematopoietic stem cells, as well as of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (PubMed:18796632, PubMed:21502331).  May promote the survival of mature T lymphocytes upon cytokine withdrawal (PubMed:16509771).  May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity).  May play a role in mitochondrial DNA segregation in hematopoietic tissues (PubMed:25808953).  Is a regulator of liver endothelial cell homeostasis (PubMed:33956074).
What are the official names of this protein?
GTPase IMAP family member 5, GTPase of the immunity-associated protein 5, Immunity-associated nucleotide 4-like 1 protein, Immunity-associated protein 3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
What are the subcellular locations of this protein?
Lysosome. Lysosome membrane; Single-pass type IV membrane protein. Endosome, multivesicular body membrane; Single-pass type IV membrane protein. Endosome membrane; Single-pass type IV membrane protein.
Protein: L10K_RAT
Sequence: MAQGQRKFQAQKPKSKAAAAERSRGPRKGGRVIGPKKARVVQQQKLKKSLEVGIRKKIEHDVVMKASSSLPKKLALLKGASKKTGATPGKTPS
What is the function of this protein?
May have a potential role in hypercalcemia of malignancy.
What are the official names of this protein?
Leydig cell tumor 10 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the UPF0390 family.
Protein: LCL2_ASPOR
Sequence: MLHTWIRTLGALLLLASVAHAQFQFFEHMFGGGRQEHQQQAAQNEPSDSSRYQNMWESAQCDKYLCPGTLACVHFPHHCPCAHPDNEDKIELSEGSAVCISKGGFQPGEAARKIELARKGVL
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.
Protein: MUTL_RHOPS
Sequence: MPVRQLPETIVNRIAAGEVVERPASVVKELVENAIDAGACRVDVFSDGGGRRKIVIADDGGGMTQADLALAVDRHATSKLDDEDLLAIRTLGFRGEALPSIGAVARLSLTTRHAAEPHAWTLSVEGGAKSPISPAALSQGTRVEVADLFFATPARLKFLKTDRTEAEAIREVVRRLAMARPDIAFTLAGEERAPVTWAAALPGAPGRLTRLGDILGADFRANAIEVGSEREGVAVEGFAASPSLTRANALGQYLFVNGRPVRDKLILGAVRAAYADYLPRDRHPVVALFVTLDSREVDANVHPAKTEVRFRNAGLVRALIVHALKEGLAREGRRTAANSAGAAISNFRPASMPPGNWDWRSSPSYPVGGGSSAAPSFGERPQAAFDVGGPSADIRPHEAAPELLDRPLGAARTQIHETYIVSQTRDGLIVVDQHAAHERIVYERLKASLDANGVQRQILLIPDIVEMDEATVERLVARAEELSKFGLVVESFGPGAVAVRETPSLLGKVNAASLLRDLAEHMAEWDEALPLERRLMHVAATMACHGSVRAGRVLKPEEMNALLREMEATPNSGQCNHGRPTYVELTLADIEKLFGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: DPO4_YERPS
Sequence: MRKIIHVDMDCFFAAVEMRDDPRLRDIPLAIGGSKERRGVISTANYPARRYGVRSAMPTAMAFKLCPQLTLLPGRMAAYKEASQHIREIFARYTPLIEPLSLDEAYLDVSDSLACGGSATLIAQEIRQSIASELNLTASAGIAPIKFLAKIASELNKPNGQYVITPNQIQPFLQDLPLSKIPGVGAVTAKRLQALGLVTCGEIQKYPLAELLKHFGKFGRVLWERSHGIDEREISPDRLRKSVGVEKTLAEDIYDWESCEALIEELYLELETRLRKVKPDLHIARQGVKLKFHDFQQTTQEHTWPVLNKADLLQIAHAAWNERRAERGVRLVGLHVTLLDPQLERQLLLDWG
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.