PharMolix/UniProtQA huggingface dataset:
Protein: UBB_HUMAN
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC
What is the function of this protein?
Exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
What are the official names of this protein?
Polyubiquitin-B.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: LPTD_PSYCK
Sequence: MLYSPLYQSIRLILFGALGLSSLTVSAAINQTDSMMPEPLVTDSSNQYADDVATDAGFNNEINNQDISYQSDSQQSAAYKKASLSSDATLSNDAAVNNNNITAINDRTKTSQDSRVAPVNTSNAAKAGNRRIDTNDESIQESLKRLAEFYELTPDTNVATSNNTGTSVNDEQNNIQNSLTPVTTNIPTVGSNLRLLPHTVDSAARCEGQWVYPKKNPNYQRAVNEASASSGQPAPNLNGLPNNQAPLFAESDYGYYDNVDYAELSGNVIIDQGTQHIEAEKIVLDLSNGVAAAQGKVMFTDQATGNVSVNGAQDRTQQNGKTSLTDKATQGGLIGVADNLNYNTETGQSTATNVAFASVELQAHGYAKRLNRPNESQYELDEVMYSTCPPTNRKWQFDAKSIDLDTETGRGEAYNTTFRIADVPVFYLPYFNFPIDSRRGSGFLLPNASISSENGLEIDVPYYFNLAPNYDATLSTHIYTTRNPMLSGEFRYLTENYGEGIFNGSYLPNDKEYDGEDRRSLFYDHYWSSTSIPRLSGEAKYSYVSDADYLNDFDTLGLSDNTLNLPRRAQLNYYNDYVDGELKVETFQTLDALNNNGQMLQDKDKPYSRLPQLKLDYRLPWAKHFDITGVSDSAYFKKSIDDGSENEKSGTRFYNKLSASYPMENSWGYIKPKLSLQHLFTTYDEDSLVDNSLDKDDGSQSVFVPQASIDAGLHFYQAGSPFGAFDDTLGGYRLLSPRLKYTYSPYRDQNDIPNFNTRIASINYEQLFSDSWFLGHDRLQDLHAFTPGINYRYIDATGVTRFDGSIGEQFYLDDGRVTLDNTKPVFTSSSSGLVWDTSTQPYNNVWVDVSGALTNSYDLNYITTELRYQPSDRSLFNVGFIKRQRDENTNQLPLSALTASAVFPINNNWRVLAQGQYDYNRNQMLDSLIGIDYEDCCFGFAVYGRRYYNDLNIAEKPTQAIMAEVRLSGLGSGSSRLTRLLADKVLGFEPVQNAWKD
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: NDUF5_DANRE
Sequence: MNVSVKSLRGVSRTWRSFSSRQGMNVFDRSMKRRQKDWASSLLDSSKYDYLREEVGSRVADRVYDVARTFPLALDVGCGRSHIAEHLSKEVVERLFLTDISSSSLRNRKTSDIPAQCVMADEEFLPFKENTFDLVLSSLSMHWINDLPGALRQIHQVLKPDGVFIGAMVGGETLYELRCSLQLAELEREGGFAPHISPYTAVTDLGNLLGQAGFNMLTVDIDEVQVNYPGMLEVMRDLQGMGESNCAWNRKLLLQRDTMLAAAAIYKEMYGNEDGSVPATFQILYMIGWKPHDSQAKPAKRGSANVSFADLSKIGKLQSDQ
What is the function of this protein?
Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages.  Acts by mediating hydroxylation of 'Arg-111' of ndufs7.  May also have methyltransferase activity.
What are the official names of this protein?
Arginine-hydroxylase NDUFAF5, mitochondrial, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5, Putative methyltransferase NDUFAF5.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane.
Protein: TSHR_CANLF
Sequence: MRPPPLLHLALLLALPRSLGGKGCPSPPCECHQEDDFRVTCKDIHRIPTLPPSTQTLKFIETQLKTIPSRAFSNLPNISRIYLSIDATLQRLESHSFYNLSKMTHIEIRNTRSLTSIDPDALKELPLLKFLGIFNTGLGVFPDVTKVYSTDVFFILEITDNPYMASIPANAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLSAIDKDAFGGVYSGPTLLDVSYTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRSLRQRKSVNTLNGPFDQEYEEYLGDSHAGYKDNSQFQDTDSNSHYYVFFEEQEDEILGFGQELKNPQEETLQAFDSHYDYTVCGGNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLIVLLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIVAFIIVCSCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVSPKNSAGIQIQKVTRDMRQSLPNMQDEYELLENSHLTPNKQGQISKEYNQTVL
What is the function of this protein?
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin.  Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Plays a central role in controlling thyroid cell metabolism.
What are the official names of this protein?
Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein: IOVO_OXYVI
Sequence: VATVDCSDYPKPACTMEYMPLCGSDNKTYGNKCNFCNAVVDSNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: G6PI_ECO24
Sequence: MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFGDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_PSET1
Sequence: MRGGKKGQQTAQKNRINEEITAQEVRLIDIDGEQAGIQSLKDAQTMADAAGVDLVEISPNAEPPVCRIMDYGKFIFEKSKELKEQKKKQKQIQIKEIKFRPGTDEGDYQVKLRNLRKFLEAGDKAKITIRFRGREMAHQEIGIELLNRIKGDLEELAVVESFPNRVEGRQMVMMMAPVAKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MHQP_BACSU
Sequence: MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESIGVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAGGFEYNLVLIAVSIGVALIGSGAYALHF
What is the function of this protein?
Putative oxidoreductase that may contribute to the degradation of aromatic compounds.
What are the official names of this protein?
Putative oxidoreductase MhqP.
What is the protein family that this protein belongs to?
Belongs to the DoxX family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: O1440_MOUSE
Sequence: MPGGRNSTVITKFILVGFSDFPKLKLVLFVIFLGSYLSTVVWNLGLIILIRIDPYLHTPMYFFLSNLSFLDFCYISSTTPKMLSGFFQKSKSISFVGCTMQYFIFSSLGLSECCLLAAMAYDRYAAICNPLLYTAIMSPSLCVHMVVGAYSTGLLGSLIQLCAILQLHFCGPNIINHFFCDLPQLLVLSCSETFPLQVLKFVIAVIFGVASVIVILISYGYIIGTILNISSVEGRSKAFNTCASHLTAVTLFFGSGLFVYMRPSSNSSQGYDKMASVFYTVVIPMLNPLIYSLRNKEIKDALQRCKNKCFSQCHC
What is the function of this protein?
Odorant receptor involved in the detection of muscone.
What are the official names of this protein?
Olfactory receptor 1440, Olfactory receptor 202-4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL16_DICNV
Sequence: MLQPKRTKFRKQQKGRNRGLAQSGNTVSFGDYGLKATTRGRLTARQIEAARRAINRHVKRGGKVWIRVFPDVPVTNKPLEVRQGKGKGNVEYWVAKVQPGTVLYEMEGVTEELAREAFRLAAAKLPVQTTFEYRKVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: MURC_LACPL
Sequence: MDKATVYYFVGIKGSGMSSLALILHDKGYQVEGSDIEQYTFTQKGLAAAGIKMLPFSEDNIREGLTVIAGNSFTDDHPEIKKAREMGLPVYRYHEFLGKLMEGFTSIGVAGTHGKTSTTGLLSHVLSHIAPTSYLIGDGTGKGTPDARFFVFEADEYRRHFVAYHPDYAIMTNVDFDHPDYYKDLADVQSAFQQFGNQVKKGIFAWGDDESLRHLDVDTPIYYYGTNDRDDFQAVNIKRTTKGSSFEVKYHDESLGKFEIPLFGEHNVLNSTAVIAVSYFEKVNLDEIRRELLDFSGVKRRFSEHQVGDMVMIDDYAHHPSEIKATLDAARQKYPDKEILAVFQPHTFSRTKALMDGFAASLSKADHVFLTNIFSSAREKSGDVSSKDLAAKLPNGGEIITTDDMSALTAYHNAVAVFMGAGDIQKYEKIYEDQMK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IVOB_EMENI
Sequence: MHLLSSLAALAAAITVAFADVQQCNAENASVRKEWGSLTPDEQLGYIDAVWCLRSLPSRLPNEQYPGVQDRVDDFVATHINLTMVIHRNAPFLPWHRQYIHLWETALREECGYNGTVPYWNWTKNPDLYTNPVFDTTQSPETSLSLSGDGAYVAPSPTDPDPDPGLDFAPGRGGGCVLDGPFKDWPVRMGPFSAAQAYPYAPVPENAFAHNPRCLQRNLDVARIQYYNNPSVLESLLAAPSIAVFQDILDRTIPGTWQQAIGAHGGGHISVGPTLADVFASPQDPVFMLHHGFIDLLWDAWQRSGSDTGEGTDRMRALNGTTMYTNPPGAEEATLDTVMEFGVLGSPKKIGEVMDIRGGEYCYRYE
What is the function of this protein?
Nonribosomal peptide synthetase; part of the pathway that mediates the biosynthesis of the gray-brown conidiophore pigment (PubMed:23617571, PubMed:28108400).  The first step of the pathway is performed by the nonribosomal peptide synthetase ivoA that catalyzes ATP-dependent unidirectional stereoinversion of L-tryptophan to D-tryptophan with complete conversion (PubMed:31573806).  While the stereoinversion is catalyzed by the epimerization (E) domain of ivoA, the terminal condensation (C) domain stereoselectively hydrolyzes D-tryptophanyl-S-phosphopantetheine thioester and thus represents a non-canonical C domain function (PubMed:31573806).  D-tryptophan is acetylated, probably by an endogenous acetyltransferase (Probable).  N-acetyltryptophan is further 6-hydroxylated into N-acetyl-6-hydroxytryptophan (AHT) by the cytochrome P450 monooxygenase ivoC (PubMed:28108400).  N-acetyl-6-hydroxytryptophan is substrate of the N-acetyl-6-hydroxytryptophan oxidase ivoB to produce the gray-brown conidiophore pigment (PubMed:2126551, PubMed:28108400, Ref. 4).
What are the official names of this protein?
N-acetyl-6-hydroxytryptophan oxidase ivoB, AHTase ivoB, Ivory mutation-related protein B, Monophenol oxidase.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
Protein: RM02_DICDI
Sequence: MVLNWRGVKSRLYSGKRRIDGRNKGLIAIRSRGGALKRKYRYIEHYKQKWMDKWLFVMRIEYDPNRSAHIALCSILKEGIYFYVISIAKLEVGSLIITSALKLGTLQVGNTTKIKNIPEGLLINNIELIENSGSKISRAAGTSSLIIKKYNKKYSLVKLSSKECRLISNECYATIGTVSNIERKLKQNKKASYSRKRGIRPIVRGLAMNPVDHPHGGRTKGGVHWKSFSGKLAYNVSSRKKTKMTSRYIIIGHRKQKIMDKQIKNG
What are the official names of this protein?
60S ribosomal protein L2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YL39_CAEEL
Sequence: MRTYSKTELFCLLDMVIELFKKEKTLAEISPPVTIVGDIHGQFEDLVRLLNTRNSSENAKSKPIYGFSTKKWVFLGDYVDRGYKSLDCICLVFSLKICFPKQYILLRGNHETRAINFRYGFRVCSVVVLKIPAKPSFIRNNKRGLSVCFNEAAVNETCRLLNISLIVRGHQMMPAGFKFFADRKLCTIFSAPRYMNEIDNSGAVMKVASNGKISISIMKNPNFAMKMFLLQMKSHNSLDHRNMRLSKNSNNLPS
What are the official names of this protein?
Uncharacterized protein F44B9.9.
Protein: YSH1_YARLI
Sequence: MARWSGQIMCFRVGHFLLVGHFLLVGNFLLTDDSDTFSFVALGGGREVGRSCHVISFKGKTIMLDAGVHPAHSGLASLPFYDEFDLSTIDILLISHFHLDHAASLPYVMQKTNFKGRVFMTHPTKGIYRWLLSDFVRVTSGAESDPDLYSEADLTASFNKIETIDYHSTMEVNGVKFTAYHAGHVLGAAMYTIEVGGVKVLFTGDYSREEDRHLNQAEVPPMKPDILICESTYGTGTHLPRLEREQRLTGLIHSTLDKGGKCLLPVFALGRAQEILLILDEYWEAHPDLQEFSIYYASALAKKCIAVYQTYINMMNDNIRRRFRDQKTNPFRFKYIKNIKNLDRFDDMGPCVMVASPGMLQSGVSRSLLERWAPDPKNTLILTGYSVEGTMAKQIINEPNEIPSAQNPDLKVPRRLAVEELSFAAHVDFQQNSEFIDLVDSKNIILVHGELNNMQRLKAALLAKYRGLKNSPREKTIYNPRNCEEVELAFKGVKVAKTVGKMAEEKPHVGQIISGVVVQKDFNYGLMGVADLREHVGLSTSSVLERQTVTVNAGVDLVKYHLEQMFGYVEMRETENVKIEEMEDDVAEEEEDKEVKQEVEDVTMEGEVKDETAEEVKKEEEVAEEFKQEVEGDSDTSAGTTFVVMNSVTVKHTPTSCTIEWVGSCLNDSIADAVLAILLTVDNSRASVKMSSKQCAHSHGHEDGHSNSSLDERVLQLSSILKAQFGDSYIVSEDGKSANIKIDAMEATISFSDLSVTGSPPPLVQRVQVAVDRAISLVAPLAQKLSAVDLVEGFKAIENVKDREENGEVKAEDEEKVKAEEKVKEEE
What is the function of this protein?
Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
What are the official names of this protein?
Endoribonuclease YSH1, mRNA 3'-end-processing protein YSH1.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: COFC_METBF
Sequence: MKAVIPYKKSSAKSRLSPVLTREEREEFVDLMLNQVIDTLKEAGVGTIDILSPSMYGLENMTKANVLLDKNDLNEALNGYLEQAEEPVIIVMADLPLLSPDHVKGITSTKEDVCIVPGKGGGTNALFIKNPSCYRVRYYGSSFLTHCSIAEKTGQSVEVYDSFFAGTDIDEPEDLVELLIHGSGAAKEYISKKFRLEMSRGRVGLVHI
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
2-phospho-L-lactate guanylyltransferase, LP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: RRF_CAUVN
Sequence: MAAAEKPVLSRYRDRMDKAVSALKEEFGSLRTGRASASLLDQVMVEAYGSTTPLNAVASVSVPEPRQINVSVWDRGVVVSVEKAIRASGLGLNPVVEGQNLRIPIPPLTEERRRDLQKIAGKYAEQQKIAVRNVRRDANDDLKKAEKDGAIAEDERKKMETEVQKMTDDAIKRIDEALKTKEHEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_PSELT
Sequence: MSMDNLVRLVEKDQYKQLPDFRPGDTVKVHVKIVEGGKERIQIFEGIVIKIRGSGLGKTFTVRKIASGGIGVERTFPYHSPVVQKIEIVKKAVTRRAKLYYIRDIRGKIRLKERKE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RSMA_DICNV
Sequence: MTEIKAVKRLGQHFLRDEGIITQLLAAIDPKPQQKILEIGPGLGALTLPVLERCHELYAVELDHRVLQPLSEKAAAVGILHLIERDILNIHFAEVAPAPIRIIGNLPYNLSSPILFHCVAQRSDIVDMHFMLQKEVVDRITAPVDTPAYGRLSVMIQLYCQVEALFDVPPEAFAPPPKVNSAVVRLIPQTQLTWNIESIAHFECVVRSAFSQRRKMLRKSLAAYFEPKELMALDVDPTARAETIDGASFARLANALYLKEKNL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_UREP2
Sequence: MSQMENSTKKVESVANVEVVTTENAKVEQKPTSPADAIQLKVNANSTIKNLKTLVSIVKLTESGAHIGLNPKKWNPKMASYIHAKRSNNHVIDILKTILFLDRAYKFLQEVSQNGGTVMFVGTRGRVVKELIKAEAERTNSFYVTQRWLGGTLTNFTNISRSLKKFNSNLALLESEEINKYSKKEQIAINKETAKLEKFYGGIKNMKQRPDVLILVDPVNDVNAIKEARKLNIPVIALANTNADPQLIDYIIPVNNYSVKSITLILGVLADSIAELHGEPTKIVGRPDSEIVLPETKSNWKQNNYDPSKRGYNPKYVNHKSTFNKFNNKKPVDSTTNEIKTNVIKAETK
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RL32_NEIG1
Sequence: MAVQQNKKSPSKRGMHRSHDALTAPALFVDSTTGEVHRPHHISPNGMYRGRKVVKAKGE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: CTU1_DROER
Sequence: MPINCKSQCGNRAALKRPKTGDALCKECFFAAFEAEIHHTISSSNLFRRGEKVAVAASGGKDSTVLAHVLKLLNERHNYGLELVLLSIDEGITGYRDDSLETVKQNRDDYQMPLKILSYEELYGWTMDRIVAQIGRSNNCTFCGVFRRQALDRGAKLLGVDSIATGHNADDIAETVLMNVLRGDTARLRRCTSIRTGGGEDTIPRVKPLKYSYEKEIVMYAHYKKLVYFSTECVFAPNAYRGHARAFLKDLEKVRPSVIMDIIYSGEQLRFKDTVKKPERGICTRCGFVSSQQPCKACVLLEGLNRGLPKLGIGKKSKGERMIAKQDQELALRERANLVKNDF
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUZ12_DROME
Sequence: MAPAKKREKDSNPDGSAANGIIGLTHGAPDASNAGSTVPPTAEGQVKLNGHQQEQELFLQAFEKPTQIYRYLRNRHETNPIFLNRTLSYMKERMSRNNKKRISFQVNSMLESITQKSEAVSQNYLHVIYDSLHEKLPARLDNESGEDLLQEQLLCEAGESVSVETTLYKITRSKRKDSTLDFQELLSKCSQIVYNPKDRVGEHATISIPLQTMRPMGEQHTLYKLLFRIKVLSPSTCNDENAETPPNKRSRPNEKMFGSELILYEKSSGFITEGEYEAMLQPLNSTSIKSFSPKKCTWETMPDSYIPLSLTYDVYQQSPMLKFHLTLSNEQLPEMISAPELQRYVQHLDAVAEMNYNNNNYNNNNNCSGLKNGSGGGNSTVCKTTPEHIQIVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCGPVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGLLSKYAAGQELMQRQREEQLKYWLDVGMHKKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDNTVLNKRQRYSDGSPGTGIGNGHGGGSGSGANRNKSNNHSLPATSNNASSSSSNSKRAIARRRSTSERTKASGSTGGGAGGVRTRLSVPAKYERR
What is the function of this protein?
Polycomb group (PcG) protein.  While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state.  Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene.  The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
What are the official names of this protein?
Polycomb protein Su(z)12, Suppressor 12 of zeste protein.
What is the protein family that this protein belongs to?
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FEN1_DROPE
Sequence: MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAEIEKFNRRLVRVTKEHAREAKELLSLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYDKLLEGLEVNNREFIDLCILLGCDYCESIKGIGPKRAIELINNYRDIETILDNLDTSKYTVPENWNYKVARELFIEPEVADASAIDLKWTEPDEEGLVKFLCGDRQFSEERVRNGAKKLLKSKHAQTQVRLDSFFKTLPSTPNAVHAAKRKAEEAKKSANNKKAKTSGGAARGRRPK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: CENPL_BOVIN
Sequence: MDSYDAPELTPRQDASSRLKDFFVGATPLQKRLESVRKQTSFIPTPPRRKIPQGSQLQEDVDPQKFAFLLHKQWTLYSLTPLYKFSYTNFKEYSKLLNAFIAAEKQKGLAVEVGDDFNIKVVFSTLMGVKGTQRDPEAFLVQILSKSQLPSEHKEGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLVNGAETNTAIIGTWFQKTFDCYFRPLAINAFNLSWMAAMWTACKMDHYMATTEFLWSVPCSPHSLDISYAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCPKYLIGVLAYLTELAVFQIE
What is the function of this protein?
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity).
What are the official names of this protein?
Centromere protein L, CENP-L.
What is the protein family that this protein belongs to?
Belongs to the CENP-L/IML3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity).