PharMolix/UniProtQA huggingface dataset:
Protein: RL38_MOUSE
Sequence: MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKDLK
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
60S ribosomal protein L38.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL38 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD6_PYRHO
Sequence: MLIAITGTPGVGKTTVAKLLAKKLNYEYVSLKDFALEKGCGRRVNDEVEVEIDELAYFIERELKGKNAVLDGHLSHLMPVDLVVVLRAHPKLIGERLRERGYDREKIGENVEAELVDAVLIEAIEEHENVIEVDTTNKSPEDVVEEIVSLINSGIKKRVGIVDWSEVYDEIIPYLRLGGE
What is the function of this protein?
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
What are the official names of this protein?
Putative adenylate kinase, AK, ATP-AMP transphosphorylase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK6 subfamily.
Protein: VLP9_BORHE
Sequence: MRKRISAIIMTLFMVLASCSNQLEAEKLAAESKNTFFDSLVKIGQGFQDIFGIFGNAIGDALGFNAVKSDDKRSKVGEHFEGVGEGLKDTKIKLDELLKEVTAAPHADTTEVKSVINNAGAVLTKLIDSVAKLAGATKSEAPIGDAGTAQAAAATPADIADVNTVIEGVKKIIEVAEKSGVKIEKGTAGAQVANANGPKVLTNNAQADANSGPALAAEVDKADPWAMIDKIKMLKLLLHLLHLRLMMTPGQLATGSANAANNGTAATNADLAAAVALKAITKGGKFTQPAANEDGAVKVAAASAVNKVLGILDAIIRKAVNLELGKIKEAVKGIKYSEITGEATESGIDQPITNKSSN
What is the function of this protein?
The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time.  Switching between these genes is a mechanism of host immune response evasion.
What are the official names of this protein?
Variable large protein 9.
What is the protein family that this protein belongs to?
Belongs to the variable large protein (Vlp) family. Beta subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: IDI2_CHLPD
Sequence: MNEKLSTPSNITIERKLNHVEICLHGNVSFEGTTTGLERYAIEHQAVPEINYADINLSATLLGRTIGAPLMISSMTGGYHEAATLNRQFAQAAEHFRIPLGVGSMRQALENNEHRESFAVVRKAAPSVPVFANIGAPEVAAGLESSQIETMLDLIQADGLIVHLNAAQELFQPEGNTNFHGFLDQLASLTAKTPVPVIAKEVGSGISAEAARLLIDAGVKVIDVAGAGGTSWQKVEEVRYIKRFGNENRFSPEALNELLNWGIPTATCLEEIGRLKKNHPQYQPIEIIASGGIQSGIDVAKTILLGASVAASAGRLLKALHEGKLLQTIEMWLNDLKAVMFLTGSLSLEQLQKKRMTLKHLPT
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAL_RUEST
Sequence: MKFFVDTAEIDAIAELNDLGMVDGVTTNPSLIKKSGRDIIEVTKEICDLVDGPVSAEVTATDAETMIAEGRKLLEIADNITVKVPLTWDGLKACKTLTDDGHKVNVTLCFSANQALLAAKAGATFISPFIGRLDDVNLDGMDLIEDIRTVYDNYGFETEILAASIRTVNHILDSARIGADVITAPPAVIKSMVNHPLTDKGLDAFLADIKAAGIKIL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_ECODH
Sequence: MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPVPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGIRVGVVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTDAPVAVSPVRSDAVKAILAQHPDVQIIVTDDGLQHYRLARNVEIVVIDGVRRFGNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVAMAGIGHPPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWWYLPVDAQLSGDEPAKLLTQLTLLASGN
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: BSL2_ORYSJ
Sequence: MDVDSRMTTESDSDSDAAAQGGGGGGFGSETSSASPSAPGTPTAMGAGGGAAPIAAAAIAAAASAAVVAGPRPAPGYTVVNAAMEKKEDGPGCRCGHTLTAVPAVGEEGAPGYVGPRLILFGGATALEGNSATPPSSAGSAGIRLAGATADVHCYDVSSNKWSRLTPVGEPPSPRAAHVATAVGTMVVIQGGIGPAGLSAEDLHVLDLTQQRPRWHRVVVQGPGPGPRYGHVMALVGQRFLLTIGGNDGKRPLADVWALDTAAKPYEWRKLEPEGEGPPPCMYATASARSDGLLLLCGGRDANSVPLASAYGLAKHRDGRWEWAIAPGVSPSPRYQHAAVFVNARLHVSGGALGGGRMVEDSSSVAVLDTAAGVWCDTKSVVTTPRTGRYSADAAGGDASVELTRRCRHAAAAVGDMIYVYGGLRGGVLLDDLLVAEDLAAAETTNAANQAAAIAAASDIQAGREPGRYAYNDEQTGQPATITSPDGAVVLGTPVAAPVNGDMYTDISPENAVIQGQRRMSKGVDYLVEASAAEAEAISATLAAVKARQVNGEAEHSPDREQSPDATPSVKQNASLIKPDYALSNNSTPPPGVRLHHRAVVVAAETGGALGGMVRQLSIDQFENEGRRVIYGTPESATAARKLLDRQMSINSVPKKVIASLLKPRGWKPPVRRQFFLDCNEIADLCDSAERIFSSEPSVLQLKAPIKIFGDLHGQFGDLMRLFDEYGAPSTAGDIAYIDYLFLGDYVDRGQHSLETITLLLALKVEYPLNVHLIRGNHEAADINALFGFRIECIERMGERDGIWTWHRMNRLFNWLPLAALIEKKIICMHGGIGRSINHVEQIENLQRPITMEAGSVVLMDLLWSDPTENDSVEGLRPNARGPGLVTFGPDRVMEFCNNNDLQLIVRAHECVMDGFERFAQGHLITLFSATNYCGTANNAGAILVLGRDLVVVPKLIHPLPPAITSPETSPEHHLEDTWMQELNANRPPTPTRGRPQAANNDRGSLAWI
What are the official names of this protein?
Serine/threonine-protein phosphatase BSL2 homolog, BSU1-like protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. BSU subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SCPB_BACAN
Sequence: MDRTEQKSIIEGLLFVSGDEGIYPEQIAKVLEIEGNEVIDILEEMQKECEGAHRGLQIVQYAKVYRFATKKEHASYYQKLIEIPTAASLSQAALETLAIVAYRQPITRTEMEEIRGVKTDKALQTLVSHLLIKEMGRAEGPGRPILYGTTKEFLDTFGLKTLDDLPPLSEENEQMNEADLFFGSLQEISK
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: DNAA_CAUVC
Sequence: MTMKGGVASQDFSAAIATACEPAANVWSKVCVALKRELGDAAFGSWIAPAMLREAATGDVVLVTSTGIARDWIRRSAWRRIGELWAAHDATGRRIDLKSRLEFEAAAGAYVEATPKAVAAEPIEIVLPVSTDAPTVVAPSAKSPRTQGLQERFTFETFVPGPANEFAHAVARRIANWADGHFNPVLFHGPYGFGKTHLLNALAWEAMRNAPEKRVVYLTAERFLSTFVRAVMDRQTAAFKEELRAADLLIIDDVHFIAGKQSTQEELFHTLTALVGEGGRVVFSADRPPSAMTEMDAHLRSHLSAGLVCGLEPADRNLRLGILERKIQTLGAAHGFEPSIRPEVMQFLADRFTDSVRELEGALNTLSARAGEGLSRMTLDEVQAILRPHLRSGEKRITIDDIQKATAEHYGMKQADLLSERRNRAVARPRQAAMWLAKQLTTRSLPDIGRRFGGRDHTTVLHAVRRIEALRAEDSALSHDLETLTRKLRG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVA_HALH5
Sequence: MGKIQIEDIIIANQTLKDVVVHTPLQKNQVLSERYECNVYLKREDMQVVRSFKIRGAFHQISSIPKEELNNGVVCASAGNHAQGVAYSCHTLQIPGKIFMPTTTPRQKVDQVKFFGKEYVEVILTGDTFDDSFNEAKEYGIKHKMTFIHPFDQEKIVAGQGTVGMEIMNDIDDNIDYLFCSIGGGGLISGVGTYIKSISPRTKVIGCEPAGAPAMKESLKQGKVIELEKIDKFVDGAAVKKVGEIPFEICQKILEDIVLVPEGKICTTILNLYNQDAIVAEPAGAMPIAALDFFKDEIKGKTVVCVLSGGNNDIGRMQEMRERSLIYEGLQHYFIIQFPQRAGALKEFILDVLGPDDDITRFEYTKKNNKSNGPVLIGIELKCDEDYHRLMDRLNKKGFEYREINKNESLFNLLI
What is the function of this protein?
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction.  The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate).  Both intermediates are unstable and short-lived.  The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia.  In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
What are the official names of this protein?
L-threonine dehydratase biosynthetic IlvA, Threonine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: PHOSP_RABVE
Sequence: MSKIFVNPSAIRAGLADLEMAEETVDLINRNIEDNQAHLQGEPIEVDNLPEDMGRLHLDDGKSPNPGEMAKVGEGKYREDFQMDEGEDPSFLFQSYLENVGVQIVRQMRSGERFLKIWSQTVEEIISYVAVNFPNPPGKSSEDKSTQTTGRELKKETTPTPSQRESQSSKARMAAQTASGPPALEWSATNEKDDLSVEAEIAHQIAESFSKKYKFPSRSSGILLYNFEQLKMNLDDIVKEAKNVPGVTRLAHDGSKLPLRCVLGWVALANSKKFQLLVESDKLSKIMQDDLNRYTSC
What is the function of this protein?
Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication.  Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA.  Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus.  Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).  Inhibits interferon induction pathways by interacting with host TBK1 and preventing the formation of dynamic cytoplasmic condensates that have liquid properties and that are essential for interferon production (By similarity).
What are the official names of this protein?
Phosphoprotein, Protein P, Protein M1.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus protein P family.
What are the subcellular locations of this protein?
[Phosphoprotein]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P2]: Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P3]: Host nucleus. SUBCELLULAR LOCATION: [Isoform P4]: Host nucleus. SUBCELLULAR LOCATION: [Isoform P5]: Host nucleus.
Protein: TADA3_HUMAN
Sequence: MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG
What is the function of this protein?
Functions as a component of the PCAF complex.  The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context.  The PCAF complex could be considered as the human version of the yeast SAGA complex.  Also known as a coactivator for p53/TP53-dependent transcriptional activation.  Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
What are the official names of this protein?
Transcriptional adapter 3, ADA3 homolog, hADA3, STAF54, Transcriptional adapter 3-like, ADA3-like protein.
What is the protein family that this protein belongs to?
Belongs to the NGG1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SG1D1_HUMAN
Sequence: MRLSVCLLLLTLALCCYRANAVVCQALGSEITGFLLAGKPVFKFQLAKFKAPLEAVAAKMEVKKCVDTMAYEKRVLITKTLGKIAEKCDR
What is the function of this protein?
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer.  May be under transcriptional regulation of steroid hormones.
What are the official names of this protein?
Secretoglobin family 1D member 1, Lipophilin-A.
What is the protein family that this protein belongs to?
Belongs to the secretoglobin family. Lipophilin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MRPG_ALKPO
Sequence: MTAVEIIISIFVLIGGFLSLLGSIGIIRFPDVYGRLHAATKSATLGVISIMLATFLFFFLVHGEFVGKLLLTILFVFLTAPVAGMMMGRSAYRVGVPLWEKSTQDDLKKMYEKKMKGSN
What is the function of this protein?
Mnh complex is a Na(+)Li(+)/H(+) antiporter involved in Na(+) and/or Li(+) excretion and Na(+) resistance.  Na(+)/H(+) antiport consumes a transmembrane electrical potential, and is thus inferred to be electrogenic.  Does not transport K(+), Ca(2+) or Mg(2+).
What are the official names of this protein?
Na(+)/H(+) antiporter subunit G, Mrp complex subunit G, Multiple resistance and pH homeostasis protein G.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UPP_DICT6
Sequence: MVIVVDHPLVQHKLTKLRDKNTGPKEFRELLFEISSLMLYEVTKNLPTKEVEVETPLGIAKGKVLDNKDLAIVPILRAGLVMADGMLQILPSAKVGHIGLYRDPETLKPVQYYTKLPEDIDKREVIVVDPMLATGGSAVAAISILKAKGVKDIKFVCIISAPEGIETLRNSHPDVDIYTAAIDERLNDHGYIIPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: CINA_STRPZ
Sequence: MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQTLAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSISLPNKTGLAVGGFITVDGISYVVLPGPPSELKPMVNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQLLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKMLGLPLEELKSYGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDVCYIATLHAFNMVRKTLLKLENLL
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: NKX23_MOUSE
Sequence: MMLPSPVTSTPFSVKDILNLEQQRHFHGAHLQAELEQHFHSAPCMLATAEGTQFSDAGEEDEEEEGEKLSYLNSLAAAEGHGDSGLCPQSYVHTVLRDACSGPKEQEEEVVSERSQKSCQLKKSLEAAGDCKTSEDGERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGTHAPPPPPRRVAVPVLVRDGKPCVTPSAQTYGSPYGVGAGAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSGSYGCAYPTGGGGGGGGTASAATTAMQPACSATGGGSFVNVSNLGGFGSGGGAQPLHQGAAAGSACTQGTLQGIRAW
What is the function of this protein?
Transcriptional regulator essential for normal development and functions of the small intestine and spleen.  Activates directly MADCAM1 expression.  Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue.  May have a role during pharyngeal organogenesis.
What are the official names of this protein?
Homeobox protein Nkx-2.3, Homeobox protein NK-2 homolog 3, Homeobox protein NK-2 homolog C, Nkx2-C.
What is the protein family that this protein belongs to?
Belongs to the NK-2 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y7642_DICDI
Sequence: MRAALEEYNQKVGPNNNNQSNTINLPPVGSNSNNINDNNNNSIQRKRGATVIGTREFHVPSDLKNHHNPYHSNYNNNNNNNNNSSSAITSGTVAPSSSMNNHQKEDDSYTSLKMRYLRSLNISIKQEAPTKDTNVSASAPIPIPIALSMGRGDLDSESDISEKEDDNDGSFDGNSSGNSFLKHNTIANSYLSGNQFKNNLNSYAGNGINSMNSLSSHFNNNNNSSNNNNNNNPNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNPNNNKNNNNNNGSNIINNSSNISKNNGFIMKSNSSNNIDNNNNNNNNNNNNNSNIYNKEDDEEQFDLDTSTTPPRKDSKGKGKHKFIPPHELLGAAGGDDD
What are the official names of this protein?
Putative uncharacterized protein DDB_G0275317.
Protein: Y2585_MYCTU
Sequence: MAPRRRRHTRIAGLRVVGTATLVAATTLTACSGSAAAQIDYVVDGALVTYNTNTVIGAASAGAQAFARTLTGFGYHGPDGQVVADRDFGTVSVVEGSPLILDYQISDDAVYSDGRPVTCDDLVLAWAAQSGRFPGFDAATQAGYVDIANIECTAGQKKARVSFIPDRSVVDHSQLFTATSLMPSHVIADQLHIDVTAALLSNNVSAVEQIARLWNSTWDLKPGRSHDEVRSRFPSSGPYKIESVLDDGAVVLVANDRWWGTKAITKRITVWPQGADIQDRVNNRSVDVVDVAAGSSGSLVTPDSYQRTDYPSAGIEQLIFAPQGSLAQSRTRRALALCVPRDAIARDAGVPIANSRLSPATDDALTDADGAAEARQFGRVDPAAARDALGGTPLTVRIGYGRPNARLAATIGTIADACAPAGITVSDVTVDTPGPQALRDGKIDVLLASTGGATGSGSSGSCAMDAYDLHSGNGNNLSGYANAQIDGIISALAVSADPAERARLLAEAAPVLWDEMPTLPLYRQQRTLLMSTKMYAVSRNPTRWGAGWNMDRWALAR
What are the official names of this protein?
Uncharacterized lipoprotein Rv2585c.
What is the protein family that this protein belongs to?
To M.bovis Mb2616c and M.leprae ML0489.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: CCD89_DANRE
Sequence: MTSPQKIPIDLKMMIKDTKQDMDDVHQALEKLRSLSQEERTEAEVLRSRIDEQSTLICILKRRADEMLLRCQALEKINAELENLRANVQVELENERKKSELLEQRFMDLASNHRELINFKNEYKSQNAKLEKENERLRKENEALFSEEVQEKEETILKLTQELKDLAEQHKILENEYQEKTTGFQIKLKELMNLHRIKEASLKNELSDTQKQLKTAVEMCAELDLKLRQTQVKESMRETDTQERLEKLIKEKDELIDLSVQRGKIIRDKQVEIQELERKRQEAENGRRHAEDRFEKEAAAVNSELRVKELREALERAEFSCNELKKEFEAFKKHSCELLEKEKELNCKLRHMII
What are the official names of this protein?
Coiled-coil domain-containing protein 89, Bc8 orange-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the CCDC89 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to hey1.
Protein: COPG2_BOVIN
Sequence: MIKKFDKKDEESGSGSNPFRHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDVIIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKRWVNEAQEAASSDNIMVQYHALGVLYHLKKNDRLAVSKMLNKFTKSGLKSQFAYCMLIRIASRLLKENEEGHESPVFDFIESCLRNKHEMVIYEAASAIIHLPNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQKYPRKHSVMMTFLSNMLRDDGGFEYKRAIVDCIIHIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNENLLPSILVLLQRCMMDTDDEVRDRATFYLNVLQQRQMALNATYIFNGLTVSVPGMEKALHQYTLEPSEKPFDMKSIPLATAPVFEQKAEITLVSTKPEKLAPSRQDIFQEQLAAIPEFMNLGPLFKSSEPVQLTEAETEYFVRCVKHMFTNHIVFQFDCTNTLNDQLLEKVTVQVEPSEAYEVLCCVPAPSLPYNQPGVCYTLVRLPEDDSIAAAGTFSCTMKFTVRDCDPDTGVPTEEGYDDEYVLEDLEVTVSDHIQKVMKPNFAAAWEEVGNTFEKEETFALSSTKTLEEAVNNIITFLGMQPCERSDKVPENKNSHSLYLAGVYRGGYDLLVRSRLALADGVTMQVTVRSKEGTPVDVILASVG
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.  In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
What are the official names of this protein?
Coatomer subunit gamma-2, Gamma-2-coat protein, Gamma-2-COP.
What is the protein family that this protein belongs to?
Belongs to the COPG family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi.
Protein: KAD6_ORYSJ
Sequence: MAAISRAIRACAAAGSRRSMASSAKEVAAAGARAAAAVARRGREREREEDGRRVQWVFLGCPGVGKGTYASRLSQMLRVPHIATGDLVRDALASPGPFSEQLAEIVNNGKLVSDEIIINLLSKRLEEGAEKGELGFILDGFPRTIRQAEILEGVTDIDLVINLKLREEALLAKCLGRRMCSQCGGNFNVASIDMEGENGGPRMYMPPLLPPPQCESKLITRPDDTEEVVKERLRVYHDLCEPVEDFYRARGKLLEFNLPGGIPESWPKLLQALNLDPGNERSAAA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Probable adenylate kinase 6, chloroplastic, Adenylate monophosphate kinase 6.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLPP_DESVV
Sequence: MPVPIVIESTGRAERAYDIYSRLLKDRIVLLGTPIDDQVASLICAQLLFLESENPEKEIHMYINSPGGSVTAGMAIYDTMQYINSPVSTLCMGQAASMGALLLAAGAPGLRFSLPHSRIMIHQPSGGFQGQATDIDIQAREVLRLKQSLNAIMSQHTGKPLEQVALDTERDYFMGPEEAQAYGLIDRVLTSRSEATDTISK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_YERE8
Sequence: METIAKHRHARSSAQKVRLVADLIRGKKVSQALETLAYTNKKAAGLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: VNNL2_DROME
Sequence: MAKNYWGFFLFCLALGLMLNLSQQASLFKRDFYTAGVVEFEPSNELSDNLAGYLEIIQSQNATSTDIIVFPESTLNSAGSTTFVPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYIVINLTEKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLYGEPKNSTFLPELSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTVNGIFSSKAVQIQLGWSYANNVNLLAAGASDPIVGNSGSGIYHGRSGSLRSVMRQESGERSIYVARVPKYRAKRRMKRDLKRQVATSSSFNIKRDYLENFTSEELKIDAGKIGNLSQNLCHGGFCCHFDLAWRSLGKPSRNTSHYSYRVGIYEGWRNEKRLDVNYIRNCGVFTCSGNSIDDCGQLLPDIQRPLVTFTHVEIRVTYPQSREFLLFPDTLLDNLLPLEPKQFEWSQKRISEESHQVRFALRKSLEVKHLLTFGIYGNYYNNECTFGVGTAEEQLECGYKNPKI
What are the official names of this protein?
Vanin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1075_STAEQ
Sequence: MDLNFDLYMNDVVEQARNEIEHAGYHQLTSAEDVDQVLQQKGTSLVMVNSVCGCAGGIARPAAAHALHYDKLPQRLVTVFAGQDKEATQQAREYFEGYAPSSPSFALIKDGKITEMIERHQIEGHDVMDVINQLQALFDKYCEER
What are the official names of this protein?
UPF0403 protein SERP1075.
What is the protein family that this protein belongs to?
Belongs to the UPF0403 family.
Protein: GET1_NEUCR
Sequence: MPSLLVVIFVIELFVQLVNTIGAATINNLLWRIALSLPLPLSAQFAAQRKKQKEYLAIRRELNATSSQDEFAKWARLRRQHDKLLEDLEKRKKELDAAKTKFDRTLTTVRVVATRGLQWFLPFWYSREPMFWLPYGWFPYYVEWFASFPRAPLGSVSIVVWQWACTGVIKLVIETVMAVVGLIVAARQKQQEKQKAKQAVPAAGGGDSKAEEAK
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
What are the official names of this protein?
Protein get-1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.