PharMolix/UniProtQA huggingface dataset:
Protein: PNS1_ASHGO
Sequence: MYGKSGPPPEGYVPQHPPAQGYAPHNPPPGYVHENPFQEPVPQGQEYSPQGQQYQFRKDQYYNLDHQGSGAPIGDASFEDKFPTEAGNRLKFNDWPFTIIFLLTVGAFIAVAVLTLRGWSLSPTSNGSGIYDGDNTHTLNTNAAILLLISCGVAVALSVFGLVLAGMYTKFFIYAAMILNTVVGLGTAITYLVLRHWSAGIVFMIFTILTAVCYWLMRSRIPFSVAVLRTVMSVMKKHPQTWLVSLLGTIVSAAFSVIFSVVLVATYIKYDPKSENGGCDVSGGSCSRGKLIGILVLVFFCGFYISEVIRNVIHCTIAGIYGCWYYFSKSDQGMPRWPAFGSLKRALTTSFGSICFGSLIVSLIQLLRQIIQLLRNGIISGISDSGWMQCLWLILDAVVGVFEWMAEYFNHYAYCFIALYGKPYLRAAKETWHMLREKGIDALINDNLINLALGFYTLFVGYTTALFSYLFLRFTKPDYNSGGGFNAVLMAFSFLIAIQLTHVATETIRSGTATFFVALGNDPEIFRVSYPQRFDEIFRAYPDVLNKLSHQHV
What is the function of this protein?
Probably involved in transport through the plasma membrane.
What are the official names of this protein?
Protein PNS1.
What is the protein family that this protein belongs to?
Belongs to the CTL (choline transporter-like) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NANR_SALPK
Sequence: MDVMNAFDSQAEDSPTSLGRSLRRRPLARKKLSEMVEEELEQMIRRHEFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIISELSGMAKDFLTHPGGIAHFEQLRLFFESSLVRYAAEHATDEQIALLTKALEINSQSLDDNALFIRSDVEFHRVLAEIPGNPIFMAIHVALLDWLIAARPSVPDRELHEHNNVSYQQHIVIVDAIRQRDPDKADRALQTHLNSVSATWHALGKKSQKMR
What is the function of this protein?
Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids.
What are the official names of this protein?
HTH-type transcriptional repressor NanR.
What is the protein family that this protein belongs to?
Belongs to the NanR family.
Protein: HEMA_I82A6
Sequence: QDYSENNNSTATLCLGHHAVPNGTIVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGRDCTLIDALLGDPHCDVFQDETWDLYVERSSAFSNCYPYDVSDYASLRSLVASSGTLEFLTEGFTWTGVTQNGGSNACKRGPASGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYVWGVHHPSTNQEQTDLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGQSGRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECVTPNGSIPNDKPFQNVNKITYGACLKYVKQSTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKKNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDIYRDEALNNRFQIKGVELKSGYKNWILWISFAISCFLLCVVLLGFIMWAYQRGNIRCNICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: HSCB_NEIG2
Sequence: MSQYFTLFRIEPAFDIGTENLEQTYRALAARFHPDKFASASAFEQKQAVMMSSTINDAYRTLKNPIDRAAYLLKTSGIDADAPEHTSFAPDFLMQQMEWRETLMEARAGNNLESLKNLDNEIRAEQEKLFCGLKQSFARQDCDTAAQQVRQGRFLDKLRHEISSAL
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: PIGX_HUMAN
Sequence: MAARVAAVRAAAWLLLGAATGLTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQEFPILKCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL
What is the function of this protein?
Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis.  Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).
What are the official names of this protein?
Phosphatidylinositol-glycan biosynthesis class X protein, PIG-X.
What is the protein family that this protein belongs to?
Belongs to the PIGX family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: ATP6_LYSSC
Sequence: MNHEAPLLEVGFLTFNKSTVMMLLVAAIIVFLIAFISTRSLKLKPTGMQNFMEWIMDFVKNIIKSNMDWKTGGRFHILGITLIMFIAVSNLLGLPFSIVYGHELWWKSPTADPTVTMTLATMILVLSHFYGVKMKGTGHYAGTFFKPMSFMFPLKLVEEFANTLTLGLRLYGNIYAGEILLGLLAGLASSGAVGFIGAIVPMMAWQGFSIFIGFIQAFIFTMLTMVYMAHKVSDDH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURA_DICNV
Sequence: MEQLKIMGGRRLEGEVTISGAKNAVLPILAATLLVKGTTVIDNVPRLRDVNTLLAVLNEMGAKAHFTAENQVSVDASNITNPVAPYELVRTMRASVLVLGPLLARFGQAKVSLPGGCAIGARPVDQHIKGMRALGAEVDVCEGYIEAKASRLRGQTLTMDVVTVTGTENILMAAVLADGTTVLHNAALEPEVSDLAHCLNAMGAKIKGIGTSTLTIEGVESLHPCHYRTLPDRIETGTLLVAAAVTGGSIVARQTSPQLLEAVLEKLEAAGCSIRRGADFVALEAKKPLQAVSLRTAPFPAFPTDMQAQFMALNCVAHGSAAIVETIFENRFMHVPELSRMGARIFIEGNTVTTFGVEKLSGAPVMATDLRASACLVIAALAAEGETVISRIYHLDRGYEAMEVKLRGLGAQIERIQEA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFT1_DROME
Sequence: MARNVLESSLLGAGFSIIFQILCRILTFGINAYIVRHVGREVLGIMNVRLLLLESTLLFLSREAINRAALSANAQQGDRCSWAQLINQMWLTVPICAVLCAPCLYIWLNWLSAVDAIYASQYEFACYAVAFSCVLELMAESAVFVAQVFCFVKLKILLNTLHILVRSAIFLWIVTGDRSAAINAFAIAQLSSAVTIVLGQYGFFYFYLKGFKDFVTQQAKKKPVAPKAWQVSLYEHMDDFPFKQLSDFLPGVMFNPNGKHFNRELQTLTLSFVKQGVLKQILTEGEKYVMSVSPVLSFGEQATYDVVNNLGSMAARFIFRPIEDSSYFYFTQTLSRDIKLAKQPQERVRQASSVLNNLLLGVSSIGLIAFTFGQSYSYPVLLLYGGPDFVAGGLPQSLLQWHCLAIYLLAVNGISEGYMFATNTSRDIDKYNYLMAIFSVSFLVLSYILTGIFGPVGFIFANCINMLSRILYSTYYIRHQYRPLSLDPLLGLWPGKLFGCTLFLAGIVCYWYQSSDLATHLGVGVLAGLACLLSWALAHRDLVRLAWRYGRRIKIE
What is the function of this protein?
May be involved in N-linked oligosaccharide assembly.
What are the official names of this protein?
Protein RFT1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RFT1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DEF98_ARATH
Sequence: MGSLRVSTVVIAVVACLSILLISPTEVDGRLVCDTPAGTCTSSSTCNDQCNTWGGNYSGGECADSSFPGLSICYCCHYVGSSAEMESM
What are the official names of this protein?
Defensin-like protein 98.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: MBLC2_HUMAN
Sequence: MSALEWYAHKSLGDGIFWIQERFYESGNRANIWLVRGSEQDVVIDTGLGLRSLPEYLYSSGLLQDREAKEDAARRPLLAVATHVHFDHSGGLYQFDRVAVHHAEAEALARGDNFETVTWLSDSEVVRTPSPGWRARQFRVQAVQPTLILQDGDVINLGDRQLTVMHMPGHSRGSICLHDKDRKILFSGDVVYDGSLIDWLPYSRISDYVGTCERLIELVDRGLVEKVLPGHFNTFGAERLFRLASNYISKAGICHKVSTFAMRSLASLALRVTNSRTSP
What is the function of this protein?
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:33219126).  Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:33219126).  Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18 (PubMed:33219126).  Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986).  Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986).
What are the official names of this protein?
Acyl-coenzyme A thioesterase MBLAC2, Acyl-CoA thioesterase MBLAC2, Beta-lactamase MBLAC2, Metallo-beta-lactamase domain-containing protein 2, Palmitoyl-coenzyme A thioesterase MBLAC2.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor.
Protein: NADB_SALTY
Sequence: MMTTPELSCDVLIIGSGAAGLSLALRLAEKHKVIVLSKGPVSEGSTFYAQGGIAAVFDETDSIASHVEDTLIAGAGICDRHAVEFVASNARTCVQWLIDQGVLFDTHVQPNGKESYHLTREGGHSHRRILHAADATGKEVETTLVSRAQNHPNIQVLERSNAVDLIISDKMGLPGPRRVVGAWIWNRNKEWVETCHAKSVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGSRFMPDVDERGELAPRDIVARAIDHEMKQLGADCMFLDISHKPDDFVRQHFPMIYAKLLDLGMDLTKEPIPVVPAAHYTCGGVVVDDYGRTDVDGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAMDIDRRMPSVHSVDALPAWDESRVENADERVVIQHNWHELRLLMWDYVGIVRTTKRLERALRRITMLQQEIDEYYANFRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPQQLAESGPSILSPLTPHINR
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSKIP_DROME
Sequence: MALVQSDENDFHALREAQRMVDSCQDFADHLIVAEFLPHCRGVAYINIRTLEQVIYCVQLSRAGYRIVSYEFDDVADEVANCDTVYESAHQLLAGISPLYGEKYGFGREPLGKRKEKQS
What are the official names of this protein?
Protein GSKIP homolog.
What is the protein family that this protein belongs to?
Belongs to the GSKIP family.
Protein: XANA_EMENI
Sequence: MPAITVKPLTPPAGSAIDFGAVITDVDLEHLTDGDFSTIRSALYTHLVVVLKNQHQLTPKAQYELTRRFDPSATQYGHGKTLDAKRSILHPDLKTIPHQPQVQVIGHGFIDSYEGLENITLKHPHHRTFHRDPIPQEDDYDSTRFYRWHIDAALYGLNPPIVTTLLAVKVPGGRRQTVRYDDGSGETMDVPLGTTAFASGERMFELLSEEDKEFALSSRVEYAPHPYIWMSPARSLPTGLGLHSDDLELPLSELPPIDESAIQILPMVWKNPATGKPALQIHPSAVRKIHCGDGTVIDDLKKVREIAYKLQRPAISPQYVYAHDWEEGDLVLFHNRGVLHSVVGAFGEGEVRLFRQCNLAAGEGVVPYRE
What is the function of this protein?
Alpha-ketoglutarate-dependent xanthine dioxygenase is a non-heme mononuclear Fe(2+) enzyme that decarboxylates alpha-ketoglutarate to succinate and CO(2) while hydroxylating xanthine to generate uric acid (PubMed:15948966, PubMed:17429948, PubMed:18036331).  Allows xanthine utilization as a nitrogen source (PubMed:15948966).  Whereas xanA is highly specific for xanthine, alpha-ketoadipic acid can replace alpha-ketoglutarate as a cosubstrate (PubMed:17429948).  Exhibits ferroxidase activity in the absence of substrates (PubMed:18036331).
What are the official names of this protein?
Alpha-ketoglutarate-dependent xanthine dioxygenase xanA.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TYPH_SHIDS
Sequence: MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEASKAVKAAIKLADKAPESTPTVYRRISE
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: GT300_AFV1Y
Sequence: MTQILVKNAFSWVNIAEDVCKFIPNCKLTVIDKEAIPSVEDTNVIYIGDLMNVKTISMLERIKAKNVVLWVDETRVPKTSYSLKNLKYNYWIVPVSQWNKEVYEEHIGHTEEIIPRCTEFRRTEGKRRGNVLFGVVSFTPGVYKRYEELLLAVDYYRKNYGELEIYAYGHTEGLPSFPGVHNMGRLGKSEIQKLYSIADFAIELGIEAFGMPSIEAWAMQVPMLYGNVNDVRNHAYGVSIDPVDFDAIDFGEYILPVPIYDEYKLAEKIREVAEIEEVPELPEKYRCSYTAKKLISYLEA
What are the official names of this protein?
Putative glycosyltransferase ORF300.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: Y934_PORGI
Sequence: MAKHHPLTDWLPTSKKEMEAKGWDEADVILFSGDAYVDHPSFGAAVVGRILEAEGLRVAIVPQPNWRDDLRDFRKLGRPRLFFGVSAGAMDSMVNKYTANRRLRSEDAYTPDRRSDMRPDYPTIVYTRILKELFPDVPVIVGGIEASLRRLTHYDYWQDKLLPGILYQSGADLLIYGMGELPLHEIAQRLIAGEPFDSLKSIRQIAYLVPKGKTPVPCENDRHLFSHEECLSDKRKQAQNFREIEIQSNRYEADRILQAVGDSTIVVNPPFPPMSTAQIDQSFDLPYTRLPHPRYKGKIISAYEMIKHSVNVHRGCFGGCAFCTISAHQGKFIASRSEASVLREVKEITEMEDFKGYLSDVGGPSANMYKMQGYDLSICKRCKKPSCIHPNVCPNLNADHRPLLDLLRRIDKNPKIKKSFIGSGVRMDLLLHNYKDKVLKKAADEYTEDLIVKHVSGRLKVAPEHSSDRVLNLMRKPPFRQFAEFTKRFQRINEAHGLRQQLIPYFISSHPGCTEEDMAELAILTKKLDFKLEQIQDFTPTPMTLATEMYYTGYHPYTLQPVYTAIKKEEKMRQHMFFFWYKREEADKIRRELHRIGRPDLIAKLFDRTTSSRNDRHTPPSTQPRKSKSKSRHS
What are the official names of this protein?
UPF0313 protein PG_0934.
What is the protein family that this protein belongs to?
Belongs to the UPF0313 family.
Protein: ATPE_ECO8A
Sequence: MAMTYHLDVVSAEQQMFSGLVEKIQVTGSEGELGIYPGHAPLLTAIKPGMIRIVKQHGHEEFIYLSGGILEVQPGNVTVLADTAIRGQDLDEARAMEAKRKAEEHISSSHGDVDYAQASAELAKAIAQLRVIELTKKAM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CNTFR_CHICK
Sequence: MANPVPSACCVVLAAVVVVYAQRHSQQDSHIQYERVGADVTMKCGSMDWDAAVTWTANGTDIDDSHLNGSYLILKNVDLTQSGQYSCYEGSSWHLKYQTYLRVGVPPKEPVLMCRSNNYPKGFYCSWHLPSPTYIPNSFNISVIHGTREMVCEKDIFPKNRCHIRYLQLFSTVKYKVTLTVTNALGKNSTTLTFDEFAIVKPDPPESVVAKPVPNNPRRLEVSWQNPSSWPDPESFPLKFFLRYRPLILDQWQHVELSDGTSHTITDAYAGKEYIIQVAAKDNDIGTWSDWSVAVHATPWTEEPKHLTTEVQITETTSTSTSSFMPPPTTKICDKGAGVGSGAVAVCWTAGLVLAAYGVLFI
What is the function of this protein?
Binds to CNTF (GPA).  The alpha subunit provides the receptor specificity.
What are the official names of this protein?
Ciliary neurotrophic factor receptor subunit alpha, CNTF receptor subunit alpha, CNTFR-alpha, Growth-promoting activity receptor subunit alpha, GPA receptor subunit alpha, GPAR-alpha.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 3 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: KTNA1_CAEEL
Sequence: MNGDVQSVIRGYLERAQVAKTMSDAGRWNEAGDLLRQLMTDVKSCKISASNRDEHDARNTFLRALEANLKLVQQNVRDEDDLHEAMTRQSGSPEPPADPDVWSKPSPPLPSSSKFGATKKGVGAAGPRPREISKSTSSMSTNPADVKPANPTQGILPQNSAGDSFDASAYDAYIVQAVRGTMATNTENTMSLDDIIGMHDVKQVLHEAVTLPLLVPEFFQGLRSPWKAMVLAGPPGTGKTLIARAIASESSSTFFTVSSTDLSSKWRGDSEKIVRLLFELARFYAPSIIFIDEIDTLGGQRGNSGEHEASRRVKSEFLVQMDGSQNKFDSRRVFVLAATNIPWELDEALRRRFEKRIFIPLPDIDARKKLIEKSMEGTPKSDEINYDDLAARTEGFSGADVVSLCRTAAINVLRRYDTKSLRGGELTAAMESLKAELVRNIDFEAALQAVSPSAGPDTMLKCKEWCDSFGAM
What is the function of this protein?
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner (PubMed:28783150).  Microtubule severing may promote rapid reorganization of cellular microtubule arrays.  Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles (PubMed:8027178, PubMed:10809666, PubMed:12885567, PubMed:19087961, PubMed:23918937).  In body wall muscles, regulates organization of myosin thick filaments (PubMed:22621901).
What are the official names of this protein?
Meiotic spindle formation protein mei-1, Katanin p60 ATPase-containing subunit A1, Katanin p60 subunit A1, p60 katanin.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle pole. Chromosome. Cytoplasm. Note=Localizes to the spindle poles and condensed chromatin during female meiosis (PubMed:10809666, PubMed:12781129, PubMed:8027178, PubMed:16338136). This localization requires mei-2 (PubMed:10809666). Also localizes to the polar body (PubMed:12781129). Ser-92 phosphorylated mei-1 is first detected on the maternal chromatin in anaphase of meiosis I, then localizes to the cytoplasm during meiosis II and quickly disappears between pronuclear formation and the first cell division, except in the polar bodies (PubMed:16338136).
Protein: RL30_RAT
Sequence: MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDA19_ARATH
Sequence: MDTGGNSLASGPDGVKRKVCYFYDPEVGNYYYGQGHPMKPHRIRMTHALLAHYGLLQHMQVLKPFPARDRDLCRFHADDYVSFLRSITPETQQDQIRQLKRFNVGEDCPVFDGLYSFCQTYAGGSVGGSVKLNHGLCDIAINWAGGLHHAKKCEASGFCYVNDIVLAILELLKQHERVLYVDIDIHHGDGVEEAFYATDRVMTVSFHKFGDYFPGTGHIQDIGYGSGKYYSLNVPLDDGIDDESYHLLFKPIMGKVMEIFRPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVKFMRSFNVPLLLLGGGGYTIRNVARCWCYETGVALGVEVEDKMPEHEYYEYFGPDYTLHVAPSNMENKNSRQMLEEIRNDLLHNLSKLQHAPSVPFQERPPDTETPEVDEDQEDGDKRWDPDSDMDVDDDRKPIPSRVKREAVEPDTKDKDGLKGIMERGKGCEVEVDESGSTKVTGVNPVGVEEASVKMEEEGTNKGGAEQAFPPKT
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response.  Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous floral organ identity genes (PubMed:23034631).  Involved in negative regulation of salinity stress response (PubMed:29018096).  Represses the expression of stress tolerance-related genes, genes coding for late embryogenesis abundant (LEA) proteins that prevent protein aggregation, and positive regulators of abscisic acid (ABA) signaling, such as ABI5 and NAC019 (PubMed:29018096).
What are the official names of this protein?
Histone deacetylase 19, AtHD1, HD.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=excluded from the nucleolus, but associated with the condensing chromatids.
Protein: TRM10_CRYNB
Sequence: MRFHLGLTEALQEREPNINASSKDLSLLHFELYRRSEPIMDIDEESYLNAGPSAPSKIPQGGEGDGLQGMSKKAMKRAAKQARLEEIKPLKRAAERERRRQRTAQLAEGYAAGTLSEADKELVERRRRVEKERKEAQRRIESGDQANDWLGGVVIDLGFDDLMTDQEIASMAQQLGYLYSSNRTAEKPVRTVIHTTFSPAASPRLWQRMENFNWHKWSRCHWWEQGLETLKSQLDPSTSILSVQSVVSKETQDKAGIDTKSLLSRLTGPQVPVDLQAGKHKLVYLSADAEDELLSLSEDEIYIIGGIVDRNRHKNLCQGKAEQLGIRTARLPIGTFLEMLPTRKALTVNQVFDILVKYLHLGDWAAAFEAVIPIRKYAPGRKAKRAKTETKRNEKVEEEVECTSAEGEEDIGVIEESAEVDPEDVFSNQ
What is the function of this protein?
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.
What are the official names of this protein?
tRNA (guanine(9)-N1)-methyltransferase, tRNA methyltransferase 10, tRNA(m1G9)-methyltransferase, tRNA(m1G9)MTase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AROB_ARTS2
Sequence: MSSESTVIKVTGKSAADNYDVVVGRGLLGRLPELLGERVKRVLVIHPRALRLTGDTVRDELASAGFTALTAEIPDAEEGKHIQVAAFCWQVLGQNDFTRSDAVVAVGGGAVTDLAGFVAATWLRGVKVIHMPTSLLGMVDASVGGKTGINTAEGKNLVGAFHPPAAVLADLDTLSTLPKNELISGMAEVIKCGFIADPAILDLVEKDPSAVTDPQSAFLRELIERAIAVKADVVSEDLKETGRREILNYGHTLGHAIELVERYSWRHGAAVSVGMMFAAELARSVGRLSDADADRHRTILETLGLPITYRRDRWQGLLDGMRRDKKSRGDLLRFVVLDGIARPGILDVPDTSLLFAAYQEIAS
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_THEKO
Sequence: MGKSLIQQRRGKGTTTFRAPSHRYRGAVRYVPLNLVQERTLRGVVEEILHDPGRTAPVARVKFEDGTKKLIIAPEGVLVGQEIYIGPEAPIAIGNTLPLAKIPEGTYVYDIEGVPGDGGKYVRAGGTYALVVSREKDKVIVQLPSGELKAFNPMCRATIGVVAGGGRLEKPIVKAGKAYYIAKARNRFWPKPRGVKMNAVNHPHGGKEHHIGRPSTVSRRAPPGRKVGHIAARRTGRRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: BIOB_BURCJ
Sequence: MTQAQTVAVQSDAIPMAAPAPQRWRVADVVALFELPFNDLMFRAQQVHREHFDANAVQLSTLLSIKTGGCEEDCGYCSQSSHHDTGLKAEKLMDVDTVLDAARAAKANGASRFCMGAAWRNPKERHMPALTEMVRGVKELGLETCMTLGMLEDEQARQLADAGLDYYNHNLDTSPEFYGQVISTRTYQDRLDTLDRVRDAGINVCCGGIIGMGESRRERAGLISQLANLNPYPESVPINNLVAIEGTPLEGTAPLDPFEFVRTIAVARITMPKAVVRLSAGREQLDDAMQAMCFLAGANSMFYGDQLLTTSNPQTQRDRALFERLGIRASQADALSDNA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.