Protein: CX3C1_MOUSE
Sequence: MSTSFPELDLENFEYDDSAEACYLGDIVAFGTIFLSVFYALVFTFGLVGNLLVVLALTNSRKPKSITDIYLLNLALSDLLFVATLPFWTHYLISHEGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVASPQFMFTKRKDNECLGDYPEVLQEMWPVLRNSEVNILGFALPLLIMSFCYFRIIQTLFSCKNRKKARAVRLILLVVFAFFLFWTPYNIMIFLETLKFYNFFPSCDMKRDLRLALSVTETVAFSHCCLNPFIYAFAGEKFRRYLGHLYRKCLAVLCGHPVHTGFSPESQRSRQDSILSSFTHYTSEGDGSLLL
What is the function of this protein?
Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:9918795, PubMed:10187784).  CX3CR1-CX3CL1 signaling mediates cell migratory functions (PubMed:11544273, PubMed:12871640, PubMed:16675847, PubMed:18322241).  Responsible for the recruitment of natural killer (NK) cells to inflamed tissues (PubMed:11544273, PubMed:16675847).  Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (PubMed:12569158, PubMed:18971423).  Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (PubMed:21037587).  Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (PubMed:12871640).  Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:18322241).  Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (PubMed:16732273, PubMed:21778362, PubMed:24487234).  Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli (PubMed:16732273).  Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development (PubMed:21778362).  Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development (PubMed:24487234).  Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi (PubMed:15653504, PubMed:29326275).  Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria (PubMed:15653504).  Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C. albicans or C. auris infection (PubMed:29326275, PubMed:33548172).  Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity).
What are the official names of this protein?
CX3C chemokine receptor 1, C-X3-C CKR-1, CX3CR1, mCX3CR1, Fractalkine receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.