Protein: HECD1_CAEEL
Sequence: MDGIDPETLLEWLQTGIGDERDLQLMALEQLCMLLLMADNIDRCFESCPPRTFIPALCKIFIDETAPDNVLEVTARAITYYLDVSNECTRRITQVDGAVKAICTRLAAADISDRSSKDLAEQCVKLLEHVCQRETMAVYDAGGINAMLTLVRVHGTQVHKDTMHSAMSVVTRLCGKMEPTDPELGKCAESLGALLEHEDPKVSESALRCFAALTDRFVRKMMDPAELAMHSNLVEHLISIMVASNDENSPTTASANILSIVLSLIGNLCRGSSLITEKVLTSPNMITGLKATLTNKEERVVTDGLRFCDLLLVLLCEGRSALPLTSVVSGDYAAGSGAERVHRQLIDAIRQKDLTALVDAIESGQVDVNFADDVGQSLTNWASAFGSIEMVQYLCDKGSDVNKGHKSSSLHYAACFGRPDVVKLLLQRGANPDLRDEDGKTALDKARERSDDDHNQVANILESPSAFMRNKEDPKVKASTSKQPGTSTKPELPNPNLVRKVLHQLLPIFCEIFQKSLNGSVRRTSLSLMRKIVENIGDLRQSAVGDGNAPAAQSARKMSTDVSAGAESLVAVVVSVMDQEDDHEGHEQVLLILESLLEKDAELWVIELVRLGVFERVEAMAKEPPKGLEEVLNAIHLEGRSRVTPMEIDFENQPSSSTAVPTANDIMDTTVPSSSGGADAESNSNPSTIEMADPESSTPSSSTQQSISKPKATASSTASSAILQVVSKLSSVASLDKSAAAVDKKPTKTVLSQGTPYRWKEWRIVRGTTSLFIWSDVLLIELPFQSNGWFRYLADNDSHVQFVTGTASVDQQMTEEEKDNFQKTERREMVSRWNAVKGVFDDDWSSVPIAVLGIPSNAKKVSQKLEVPAWELWSSKSSELQIKSISSSAPTGQANTMLTTIKDDAGGFLFETGTGRKTNVMPEHALPSDFHTGWSSHGVSTRKMKFRQDIQKRKVQELAWKLWNDHLKEAHAKPREALVRLENAARTIESTIRHVKAQSNFKHRNVKQPRIERVQEYCAAISTLHESIVDDRRLSTFEFSVSGIVPALFGLLSMMEKFPDSFPSRIFKEQFSKGEALSYLALKIVAVLEANEKFPQHLYDSPGGSSFGLQLLSRRVRTKLEMLPRADGKENNDENLVNKTGKIVKCEPLASVGAIRAYLHRMVTRQWHDRERANYRYVKEIQELKTKGKSIELRHVSDFDENGVIYWIGTNGRAAPLWTNPATVKAVKITCSDTRQPFGKPEDLLSRDQNPINCHTSDDKNAHFTIDLGLFVVPTSYSLRHSRGYGRSALRNWMLQGSVDAKRWENVIVHTDDKGLGEPGSTATWHVGEKGTTAFRFFRIAQNGKNSSGQTHYLSCSGFEIYGDIVDVVTEAICEDPPKKDSPAGTSSTPGSSSSAALPPLTKEQVLEMLPARENNNRLKSGLSLETVTSMLQRSRHRSRGSYKISESKSKVVRGKDWRWEDQDGGEGKFGRITSPPESGWVDVTWDNGNANSYRFGANGNFDIERVTSTGHRYSTPSLASHVPTSVMEAVRRNRAFYTPKTTGGPPSSSVFGTSSSAGSSRGAASALSRFASVKNTTPAGTPSSGGSSGGAIGKKSMSTTNLVDERQKTSGPSVASTGQAASAESLQHQTPSLENLLARAMPHAFGRIAENQEPEDEPMGGEESDSAASMRSAASSNSQMSMGSSSQQQQQQDSDMTPRDSAGTPSTPRDDKNQTLSVSAPDLAAARQRQASAETDGDADADETNSEDKTVGADDAMEEDDEEEETMEDEEDDDDDDDDESSNENQEKLVELLGGERGLFDKLKEVITGESLSDASSSAKDATTNEAQKKGGKKPKKWFKKMSSYTDVLKGLMQNRYPVALLDPAAAGIEMDEMMDDDDYYDFSEDGPDDGDSVEDEVAAHLGMPVDSFASMVAARTPITWRQFSELMSGSNRERAAMARAVASSRGSPWEDDATVKCTFEALIPAFDPRPGRSNVNQTLEVELPTVVKDFGSTKASSSKIDKDDQMRFFLRGPNMSGVDNVTIEMNDDSASLFRYMQIINNSVNWATKSDRSRRIWEPTYSICYCSADQTNVEVSKIPDEESSTPCQVNQCLETIGLLSRIQQAMPEAEITPNVFISDKLTLKVTQVLSDALVVAARSLPEWCSRLVYKYPCLFTVETRNMYMQATAFGVSRTIVWLQQRRDAAVERARGSAQAGNSSAARQHDRYHEYRVGRLRHERVKVTRAEETLLDQAIRLMKFHADRKAVLEIEYTNEEGTGLGPTLEFYALVAAELQRKSLALWVCDDDDTHASKSGEEREVDLGEGKKPIGYYVRRVGGLFPAPLPPGTDETKRAADMFRVLGVFLAKVLLDGRLVDLPLSRPFLKLLVHPQIGDDARGPNLHKILSLDDFEEVNPVKGSFLKELRALAQRKRLIENDTSIDSNSKRRKIAELKLHIKGSTCRVEDLALNFTVNPPSKVFQYAEMELVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRVFPLRTLRAYSPEEVQRLLSGEQCPEWSRDDILNYTEPKLGYTRESPGFLRFVDVMEALTAQERKNFLQFATGCSSLPPGGLANLHPRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSAILRERLLTAINEKGFHLN
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity).  Involved in the ubiquitination and proteasomal-mediated degradation of cytoplasmic and mitochondrial proteins (PubMed:24703696, PubMed:21673654).  Positively regulates lin-12 activity in the anchor cell (AC)/vulval precursor (VU) cell fate decision (PubMed:25552605).  Negatively regulates glp-1 activity in germline proliferation (PubMed:25552605).  May play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis (PubMed:20153198).  Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci (PubMed:27669035).
What are the official names of this protein?
E3 ubiquitin-protein ligase hecd-1.
What is the protein family that this protein belongs to?
Belongs to the UPL family. K-HECT subfamily.