PharMolix/UniProtQA huggingface dataset:
Protein: CRTC2_HUMAN
Sequence: MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGSGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYTRHIDSSPYSPAYLSPPPESSWRRTMAWGNFPAEKGQLFRLPSALNRTSSDSALHTSVMNPSPQDTYPGPTPPSILPSRRGGILDGEMDPKVPAIEENLLDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGNSTSNLTHTMTHLGISRGMGLGPGYDAPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLARHVLPTTSLGHPSLSAPALSSSSSSSSTSSPVLGAPSYPASTPGASPHHRRVPLSPLSLLAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLSTDQRLPPYPYSSPSLVLPTQPHTPKSLQQPGLPSQSCSVQSSGGQPPGRQSHYGTPYPPGPSGHGQQSYHRPMSDFNLGNLEQFSMESPSASLVLDPPGFSEGPGFLGGEGPMGGPQDPHTFNHQNLTHCSRHGSGPNIILTGDSSPGFSKEIAAALAGVPGFEVSAAGLELGLGLEDELRMEPLGLEGLNMLSDPCALLPDPAVEESFRSDRLQ
What is the function of this protein?
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.  Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation.  Enhances the interaction of CREB1 with TAF4.  Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway.  Regulates the expression of specific genes such as the steroidogenic gene, StAR.  Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.  Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
What are the official names of this protein?
CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, TORC-2, Transducer of CREB protein 2.
What is the protein family that this protein belongs to?
Belongs to the TORC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (PubMed:15454081). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:15454081).
Protein: 1A1D_BRASB
Sequence: MLRLDKFKKYPLTFGATPIEHLPRLTAALGGKVQIYAKRDDCNSGLAMGGNKLRKLEYIVPDAIESNADTLVSIGGVQSNHTRMVAATAAKIGMKCVVVQESWVPHEDAVYDRVGNILMTRLMGADSRIVPDGFDIGIRKSWEDAIQSVKDAGGKPYGIPAGASVHKFGGLGYVGFAEEVRAQEAEMGIKFDYIIVCVVTGSTQAGMIVGFAADGRADRVIGIDASGTPEQTRTQVRQIVDNTAELVELGRKVRDDEIVILEDYAYPAYGVPSAETNEAIRLAARTEAMITDPVYEGKSMQGMIDLVKKGYFPEGSKVLYAHLGGAPAINGYSYTYRNG
What is the function of this protein?
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate.  Allows growth on ACC as a nitrogen source.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate deaminase, ACC deaminase, ACCD.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: IOD3_BOVIN
Sequence: MSRQAAPRWVVGEGRGTLGGAATMLRSLLLHSLRLCSQTASCLVLFPRFLGTAFMLWLLDFLCIRKHLLGRRRRGQPEIEVELNSDGEEVPPDDPPVCVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECALVLDTMTNSSSSAYGAYFERLYIIQSGTIMYQGGRGPDGYQVSEVRTWLERYDEQLHGPQPRRV
What is the function of this protein?
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine).  RT3 and T2 are inactive metabolites.  May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones.  Can regulate circulating fetal thyroid hormone concentrations throughout gestation.  Essential role for regulation of thyroid hormone inactivation during embryological development.
What are the official names of this protein?
Thyroxine 5-deiodinase, 5DIII, DIOIII, Type 3 DI, Type III iodothyronine deiodinase.
What is the protein family that this protein belongs to?
Belongs to the iodothyronine deiodinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Protein: PAND2_POLSJ
Sequence: MFRTLLKSKIHRVAVTHCELHYEGSCAIDEDLLDAANIAENEQIHIWNINNGERFVTYAIKGERGSGMISVNGSAARRAAAGDLIIIAAFAQVHNDQVSAHEPQLVFVDDKNRQTELRHKVPTQRM
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase 2, Aspartate alpha-decarboxylase 2.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTGES_HORSE
Sequence: MPPPSLAMVSGQALPAFLLCSTLLVIKMYAVAVITGQVRLRKKAFANPEDALRHGGLQFHRDDQDVERCLRAHRNDMETIYPFLFLGLVYSFLGPDPFVAQMHFLVFFLGRMVHTVAYLGKLRAPTRSLAYTVAQLPCASMALQIVWEAARHL
What is the function of this protein?
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway.  Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity).  Plays a key role in inflammation response, fever and pain (By similarity).  Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2.  In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
What are the official names of this protein?
Prostaglandin E synthase, Glutathione peroxidase PTGES, Glutathione transferase PTGES, Microsomal prostaglandin E synthase 1, MPGES-1.
What is the protein family that this protein belongs to?
Belongs to the MAPEG family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cytoplasm, perinuclear region. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment.
Protein: RL1_ACIB3
Sequence: MAKLTKRQKAIAAAVEANKVYTLEEAVQVLNSLPAAKFKESLDISVNLGVDPRKSDQVVRGATTLPAGTGKTVRVAVFAQGAQAEAAKEAGADVVGFDDLAESIQGGNLDFDVVIAAPDAMRVVGKLGTILGPRGLMPNPKVGTVTPDVAGAVKNAKSGQARYRVDKAGIIHAAIGQVGFDAAAIRQNVETLVADLKKLKPATSKGVYIKKITLSSTMGPGLTVDVNNVSN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: CHLB_SYNJB
Sequence: MKLAYWMYAGPAHIGTLRVASSFKNVHSIMHAPLGDDYFNVMRSMLERERDFTPVTTSVVDRQVLARGSDEKVIRNIVRKDGEEQPDLIVVTPTCTSSILQEDLHHFVRQAQLASRCDVVLADVNHYRVNELQAADRTLQQIVEFYITKARKSGELDGLPQKTERPSCNILGISSLGFHNAHDLRELKALLRDLDIDLNLVIPQGASVHDLKHLGRAWFNVVPYRELGPMTARYLQQEFGMPYIEITPMGVVETARFIRQIQQILNEQGIPVDYEAYIQEQTLHISQAAWFSRSIDCQNLTGKKAVVFGDSTHAAAITKILAREMGIHVVWAGSYCTYDGEWFQAEVGEYCDQILMTEDHTRVADAIAQAEPAAIFGTQMERHVGKRLRIPCGVISAPIHVQDFPIGYRPFLGYEGANQIVDLIYNSFTLGMEDHLLEIFGGHDTKEVIHKSLSADSDLIWTREAQAELDKVPGFVRGKVKRNTEKFARERGLTEISVEVMYAAKEAFGA
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: PFKA_CLONN
Sequence: MKTIAVLTSGGDAPGMNAAIRAVVRTGLDKGLKVMGIQRGYSGLINGEIFEMHRYSVADIIHRGGTILRTARCEEFKTEAGRKKGVNILKAFGIDGVVVIGGDGSFQGAQLLSKLGVKTIGIPGTIDNDLAYTDYTIGFDTATNTVLDAINKLRDTSSSHERVSIVEVMGRGCGDLALFAGIGGGAESVIVPEKEFNEDELCKTILEGKLRGKLHNLIILAEGVGGGEALTKKVQETTGIQTRLTTLGHLQRGGSPSAFDRILASRLGVKAVELLLEGKSSRVVGLRNNKVVDDDIDEALSMKSKFDDELYDIAKILSY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_CHLTA
Sequence: MALRFEILHQSKKSRARVGRIETAHGYIDTPAFVPVATNGALKGVLDHSNIPLMFCNTYHLIVHPGAEAIAAMGGLHQFIGRNAPIITDSGGFQIFSLAYGSVAEEIKSCGKKKGGNTIIKVNDDGVHFKSYRDGRKLFLSPEISVQAQKDLGADIILPLDELLPFHADPTYFHQSSQRTYVWEKRSLDYHLKNPGIQSMYGVIHGGTFPDQRKLGCKFVEDLPFDGSAIGGSLGKNLQDIVEVVGVTAANLSAERPRHLLGIGDLPSIWATVGFGIDSFDSSYPTKAARHGMILTLQGPLKINNQRYSSDLNPIEPGCSCLACSQGITRAYLRHLFKVHEPNAGIWASIHNMHHMQKVMREIREGILNDRI
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: TOP2_CANGA
Sequence: MSEPKTASERYQKISQLEHILKRPDTYIGSVEIQEQEQWIYDEETDCMIDKTVNIVPGLFKIFDEILVNAADNKVRDPSMKRIDVTINPEENFIEVRNDGKGIPIEIHEKEKIYIPELIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFTLETADPKNGRKYVQTWENNMNVCHPPKITSYKKGPSYTKVAFKPDLSRFGMESLDSDILGVMRRRVYDINGSVRDVNVYLNGKPLKIRNFKNYVELYLKSLEKMRKMDNGESDTTPSNIPTILYERVSDRWEIAFAVSDISFKQVSFVNSIATTTGGTHVNYIADQIVRKVSDILKKKKKNIKPYQIKNNMFIFINCLIENPAFTSQTKEQLTTRVKDFGSRCDISSDYINKIMKTDLATKIFEIADENANNALKKSDGSRKSRITDYPKLEDANKAGTKDGYKCTLILTEGDSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREATADQILKNAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIKGLIINFIETSFPGLLDIPGFLIEFITPIVKVTITKPIKKVISFFNLPDYEKWREEESHKYSWKQKYYKGLGTSTSPEIIEYFSNLDTHLKKFHALQGDDKDLIDLAFSKKKADDRKEWLRQYEPGTVLDPTLNEIPISDFINKELILFSLADNVRSIPSVLDGFKPGQRKVLYTCFKKNLTTEKKVANLAPAVSDYTAYHHGEQALVQTIIGMAQNFVGTNNIYFLKPNGAFGTRATGGKDAAAARYIYTELNKIARKVFHPADDPLFRYVQEDEKTVEPEWYLPVVPMVLINGAEGIGTGWSTSIPPFNPLDVVNNIRHLLNDEEMDDMHPWFRGWTGTMEKIESQRYRMYGRIEQVGPNTLEITELPARTWTSTIKEHLLLGLGGSEKVKPWIKDMEEQHAETIKFIIKLTDEEMTKTRKLGFYERFKLISPISLQNMVAFDYRGKIKKYDHVHEILKDFYEVRLEYYQKRKDYMTGRLQWEAEKLSFQVKFIKMIIDKSLIVTNKPKKQLISELEELGFPRINKEGKPHFGKIDEEVEAIISEDEDEDLEESEEATRKKDKDDESTVNGPEELFGTYEYLLGLKIWSLTKERYEKLLKQKQEKETELENLLKLSAKDLWNNDLDDFLTAYEDFQKMDLFLRNSAVPKTKGGKRKRKGGDDDDYDPSGKKKPARRIKKIKKEDDFDRILIKPQAKIKAKRPVKVKVEPPSSAASTPSVKEELGVSDVTSNASTPSTTIFDQKVKQENSDESGISAFSSKFNKIASAFDEDAPLDQITSEDTSVKESSAPAAKKKAPPKRKAKVVESSEDELSDANLSEQDDEEVVPVRRQRSSRQTAKKSYAEPIEISDEEDFIDDDEDEEVDSDESFNDE
What is the function of this protein?
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands.  Topoisomerase II makes double-strand breaks (By similarity).
What are the official names of this protein?
DNA topoisomerase 2, DNA topoisomerase II.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OPSD_SARPU
Sequence: TEGPFFYIPMVNTSGVVRSPYEYPQYYLVNPAAYAILGAYMFFLIIIGFPVNFMTLYVTLEHKKLRTPLNYILLNLAVADLFMVIGGFTTTMYSSMHGYFVLGRLGCNMEGFSATLGGMISLWSLAVLAIERWVVVCKPISNFRFGENHAIMGVSLTWFMALACTVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVLYMFFCHFLVPLVIIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIIMVIGFLVCWLPYASVAWFIFTHQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRNCMITTLFCGKNPFEGEEEGASSTKTEASSASSVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: LYSM4_XENLA
Sequence: MRLREGPTHSFQPPSSVHSSLGSHVYTFSNGTAEADSSSEEEFDVMELRARGGEQQRINASREKVGNVILLERAITEDDNLNKLALQYGCKVSDIKRVNNLITDQDIYALKTIKIPVKVHGLLTERRDELTAFNASAPPEPEKELSLPSMESRDFTVYFKAIDQNIEEAAAQTHDLFNESFALDSPSLPPTRILGQKQPASGADWGIRWWNAVFIMLLVGIVLPVFYIVYFKTQGDSEGTFSIEGRTNVSTSLSPHTNTGHSMEQMTQRTSGFSPGLLQDTHKLLNPGG
What are the official names of this protein?
LysM and putative peptidoglycan-binding domain-containing protein 4.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL31_NEIMB
Sequence: MKQGIHPNYHEVNVTCSCGNKFATKSAMEKENFNIEVCSLCHPFYTGTQKIVDTTGRVDKFNNKFGNLFKR
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: TSAD_STAHJ
Sequence: MNKETLILAIETSCDETSVSVIKNGNSILSNIVLSQIESHKRFGGVVPEVASRHHVEGITTTIEEALTTANISMNDIDAIAVTQGPGLIGALLIGINAAKALAFAYDKPLIPVHHIAGHIYANHLEEPLTFPLITLIVSGGHTELVYMKSHMHFEVIGETRDDAVGEAYDKVARTIDLPYPGGPQIDKLAQYGKDTYDFPRVWLEKESYDFSFSGLKSSVINKLHNLRQKNEEVVKEDVATSFQNSVVDVLSTKAINACKAYKVNRLIVAGGVASNKGLRYRLQQLCEDNNIHLSIPSPKLCTDNAAMIGAAAYYYYQSGITAKLDLNGENNMDIEEATIEV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBC1_YEAST
Sequence: MSRAKRIMKEIQAVKDDPAAHITLEFVSESDIHHLKGTFLGPPGTPYEGGKFVVDIEVPMEYPFKPPKMQFDTKVYHPNISSVTGAICLDILKNAWSPVITLKSALISLQALLQSPEPNDPQDAEVAQHYLRDRESFNKTAALWTRLYASETSNGQKGNVEESDLYGIDHDLIDEFESQGFEKDKIVEVLRRLGVKSLDPNDNNTANRIIEELLK
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system.  Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 1, E2 ubiquitin-conjugating enzyme 1, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-24 kDa, Ubiquitin-protein ligase.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: RIMP_CYAP4
Sequence: MTHPLIPEILDLAVPLAADLNLEVVGAVFHTHLNPPVLRVDIRNLSADTSLEDCERMSHRLETALDAADLVAGTYVLEVSSPGISRLLSSDREFVSFRGFSVIVRTREPIAGQREWVGNLVQRDEEFVYLNQKGRAISIPRHLVTQVQLNEKRS
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCX13_CENEX
Sequence: ATGNVWAKDGYLVIIKTGCKYNCYILGKNKYCNSECKEVGAGYGYCYAFGCWCEGLPESIPTWPLPDKTCGTK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Neurotoxin Cex13.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMA_PROA2
Sequence: MTKVQYKHTEIAVKKKLGQNFLTDRNTIRKIVQSAEIQPGDHVVEIGPGFGALTSAILEVCPSFTAVEKDRKLADFIREEYPSVNLVESDILEVDFAKLAEEGPVKVMGNIPYSITSPILFKLLENRSHIISETLMMQHEVALRLAANPGTKEYGILAVQLQTFCDVRYLFKVGKKVFRPRPEVDSAVVRIVPKKTPLDDCETEFRRFVRLAFQQRRKTLQNNLKQHYDISQLSASELQRRAESFTITEFEMLFSRIRPLQ
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MALT_SCHPO
Sequence: MKVVPSEKIKPNWWRETSVYQIYPASFKDSNGDGFGDLEGIISKVDYLKALNVESIWLCPIYPSPLKDMGYDVSDYKQIDSRYGTLEDLDRLMKALHERDMKLVMDLVLNHTSDQHEWFKESRSSKTNPKRDWYFWKPARYNEKGERLPPNNWRSYFDTSAWEWDEATQEYYLHLWSVGQPDLNWETPKVREAVHDILRFWLDRGVDGFRLDAINMISKDQRFLDAPITDDRYEYQLAYQYYANGPRIHEYLNGIGNILTEYDAFSVGEMPYVLDTNEILHVVGADRRELTMIFQFDFVDLDLDPNQHKYIEGSWELSDLKKSLKKWQSALLSGGGWNASFIENHDQTRTVSRYLSDSPKYRAYSSKLMALFIIFQSGTPFVFQGQELALANIPRDWPIDEYLDVETQNFWKLFMSGNPSQEEIEKTMDIVNKRARDNGRTPMHWDSSPNGGFTKAGVKPWMRVTNDYKEWNAANQVNDPESPYTFWSKALELRKELKDAVVYGSFELISEEDPSIVAFVRESSTYKLIILLNFTGNKVSYDCPLNLTSYEILLDNYKDFICMTSPVTLNPYQAVLLKL
What are the official names of this protein?
Alpha-glucosidase, Maltase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: MEND_COREF
Sequence: MSVTPAQELAREVIEALSPHITDVVLCPGSRNSPLSLEVLSREDLRVHVRIDERSAAFLALGLARVQRRPVPVIMTSGTAVSNCLPAVTEAAHAHIPLLVVSADRPAHLIGTGSSQTIDQTDIFGALAPTVTVAAPEHVGRISQALGNGASQSPRHINVALDMPLVAPDLPELHGQRGPVDWEQRWVDHGVVDVDLSRNTLVIAGDEAWEIEELAEVPTIAEPTAPVAYHPVHPLAAEFLLKDQVSAEGYVVTTRPDHIIVVGHPTLHRGVLKLMTDPTIELTVLSRTDVITDPGRHADRVGSRVKVTGEQQKQWLKICDAASDLAAEGVREVLAKEEHGFTGLHVAAAVADGLGTGDTVFCAASNPIRDLSIVGLPFAGVDVHSPRGTAGIDGSVSQAIGTALAIQARHPDEIRAPRTVALLGDLAFIHDAGGLLIGPDEPRPENLTIVVANDNGGGIFELLETGAPGLRSRFERAFGTPHDVNISDLCDAYGVDYRRANTLQDLLMELEDTIEIPGFTVIEAVTVRDTRRALQRELTAKVR
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: EFNA1_RAT
Sequence: MEFLWAPLLGLCCSLAAADRHIVFWNSSNPKFREEDYTVHVQLNDYLDIICPHYEDDSVADAAMERYTLYMVEHQEYVTCEPQSKDQVRWKCNQPSAKHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIYHQETQCLKLKVTVNGKITHSPHAHANPQEKRLQADDPEVQVLHSIGHSAAPRLFPLVWAVLLLPLLLLQTQ
What is the function of this protein?
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.  Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  Plays an important role in angiogenesis and tumor neovascularization.  The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.  Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2.  Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation.  Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK.  Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).
What are the official names of this protein?
Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. SUBCELLULAR LOCATION: [Ephrin-A1, secreted form]: Secreted.
Protein: QUEA_STAA1
Sequence: MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLNDTRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECIKEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTAGLHFTDELLTEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLNDTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLPKSTLVMLVSAFSTRENVLNAYKTAVNLEYRFFSFGDAMLII
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCS1_CYACA
Sequence: MVSITLKTNRIFRSCLNLATNLKFSITLFIIICIVSAIGTIIPQDKPKEFYMNTYSLKVLGMPLWKIIQLLSLEKIFYSNFYLILLLCLSFSLFFCSLKSQFPYLRTSRIIKLNNNNPPTSPLHESKKIKYNNIASKNDSSCVQLVSQGYKIYTFDKNLDKAGPLLIHLSLILILLGSAIHAFNDFIAQEMIPIYEVSHIQNVISSGRISKIPQTISLKASAFTVEHENEKVVKQFITNLAMLNSKGEVLKQGLVSVNHPLVYKQVYIFQMDWKLFGIRVNYGKNKIYEFPVQKIEANNEQQWSCTIPAKNQSKLILIFKNMSDEFYVYDNNQNFLKIGKINTPQLIRNTYFTVISKISGTGLQIKKDSSINIVYTGFLLLIIGLVINHKGSKKRT
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein Ccs1.
What is the protein family that this protein belongs to?
Belongs to the Ccs1/CcsB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.