PharMolix/UniProtQA huggingface dataset:
Protein: MDTL_ECOBW
Sequence: MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA
What is the function of this protein?
Confers resistance to chloramphenicol.
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AGR2_MOUSE
Sequence: MEKFSVSAILLLVAISGTLAKDTTVKSGAKKDPKDSRPKLPQTLSRGWGDQLIWTQTYEEALYRSKTSNRPLMVIHHLDECPHSQALKKVFAEHKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIVFVDPSLTVRADITGRYSNRLYAYEPSDTALLYDNMKKALKLLKTEL
What is the function of this protein?
Required for MUC2 post-transcriptional synthesis and secretion.  May play a role in the production of mucus by intestinal cells.  Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity).  Promotes cell adhesion (By similarity).
What are the official names of this protein?
Anterior gradient protein 2 homolog, AG-2, mAG-2, Protein Gob-4, Secreted cement gland protein XAG-2 homolog.
What is the protein family that this protein belongs to?
Belongs to the AGR family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum.
Protein: S22AO_PONAB
Sequence: MGFDVLLDQVGGMGRFQICLIAFFCIANILLFPNIVLENFTAFTPGHRCWVPLLDNDTVSDNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLKGTFPNTNETDTEPCVDGWVYDRTSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPQSRSMAIMVLLCSYSVGQMLLGGLAFAIQDWRVLQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHTNGKKNTEETLTAEVIWKGEMIAVIK
What is the function of this protein?
Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids including estradiol-17beta-D-glucuronide (or 17beta-estradiol 17-O-(beta-D-glucuronate)), androstanediol glucuronide (or 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), and estrone 3-sulfate, as well as bile acids taurocholate and glycocholate, driven by an outward gradient of dicarboxylates such as glutarate or succinate.
What are the official names of this protein?
Steroid transmembrane transporter SLC22A24, Solute carrier family 22 member 24.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RUVB_DESHY
Sequence: MEERMITPQQLPGDQEGEVLRPHRLADYIGQTKVKDNLQIFIQAALARGEALDHVLLYGPPGLGKTTLANIIATEMEVNIRTTSGPAIERPGDLAAILTSLEPRDVLFIDEIHRLSRTTEEILYSAMEDGCLDIVIGKGPSARSIRLTLPPFTLVGATTRAGQLASPLRDRFGVISRLEFYEVEDLIRIITRAAGILNLQITLEGASEIARRSRGTPRVANRLLKRVRDYAQVWEDGRVTQELAGKSLDRLEVDPAGLDRIDQKCLLTIIQMFAGGPVGLETLSATIGEEAETIEDVVEPYLLQQGFIQRTPRGRVATVRAYQHLNIPVNSSHQEGGQGDSLFDAAED
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: HLH14_CAEEL
Sequence: MAKKNQVARNERERKRVHQVNHGFDVLRNRLQPKNHTKKWSKADTLREAVKYIQQLQVLLNQDPQQPSVSSSTPDYTMNNSNNFNNYAVKEEFSMYLPQNYCPQNQMSVPHGDVSHNFNSPTSSVSSSSYSPTQMCYPPVSYSNYPHH
What is the function of this protein?
Probable transcription factor, involved in determining neuroblast cell fate, morphogenesis and aspects of terminal differentiation in both left/right symmetric and asymmetric neuronal lineages.
What are the official names of this protein?
Helix-loop-helix protein 14.
What are the subcellular locations of this protein?
Nucleus.
Protein: LHW_ARATH
Sequence: MGVLLREALRSMCVNNQWSYAVFWKIGCQNSSLLIWEECYNETESSSNPRRLCGLGVDTQGNEKVQLLTNRMMLNNRIILVGEGLVGRAAFTGHHQWILANSFNRDVHPPEVINEMLLQFSAGIQTVAVFPVVPHGVVQLGSSLPIMENLGFVNDVKGLILQLGCVPGALLSENYRTYEPAADFIGVPVSRIIPSQGHKILQSSAFVAETSKQHFNSTGSSDHQMVEESPCNLVDEHEGGWQSTTGFLTAGEVAVPSNPDAWLNQNFSCMSNVDAAEQQQIPCEDISSKRSLGSDDLFDMLGLDDKNKGCDNSWGVSQMRTEVLTRELSDFRIIQEMDPEFGSSGYELSGTDHLLDAVVSGACSSTKQISDETSESCKTTLTKVSNSSVTTPSHSSPQGSQLFEKKHGQPLGPSSVYGSQISSWVEQAHSLKREGSPRMVNKNETAKPANNRKRLKPGENPRPRPKDRQMIQDRVKELREIIPNGAKCSIDALLERTIKHMLFLQNVSKHSDKLKQTGESKIMKEDGGGATWAFEVGSKSMVCPIVVEDINPPRIFQVEMLCEQRGFFLEIADWIRSLGLTILKGVIETRVDKIWARFTVEASRDVTRMEIFMQLVNILEQTMKCGGNSKTILDGIKATMPLPVTGGCSM
What is the function of this protein?
Transcription activator that regulates root development; promotes the production of stele cells in roots.  Coordinately controls the number of all vascular cell types by regulating the size of the pool of cells from which they arise.
What are the official names of this protein?
Transcription factor LHW, BHLH transcription factor delta, bHLH delta, Basic helix-loop-helix protein 156, AtbHLH156, bHLH 156, Protein LONESOME HIGHWAY, bHLH transcription factor bHLH156.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family. LHW subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SRS12_MOUSE
Sequence: MRSFSGAVWERQVSLGAPSWPAAMGDRIYSLEARAVARSVLARPRRPRAPRPRLRLRGRPGRGRGGLLGAGPREACLATPGPPTPPCSSGTSQTPPAPGQMKSKERHLCSPSDHRRSRSPSQRRSRSRSSSWGRDRRHSDSLKESRHRRSSYSQSKSRSKSLPRQSTSLRQSRTPRRNSGSRGRSRSKSLPKRSKSMEKSQSRSPQKQTGSGAKSRPHGRHCDSIARSPCKSPRAYTSSGSKTQTTKHSHLRSHSRSRSYHHKNSW
What is the function of this protein?
Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.
What are the official names of this protein?
Serine/arginine-rich splicing factor 12, Splicing factor, arginine/serine-rich 13B.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OTC_BACCR
Sequence: MSTVQVPKLNTKDLLTLEELTKEEIISLIEFAIYLKKNKQEPLLQGKILGLIFDKHSTRTRVSFEAGMVQLGGHGMFLSGKEMQMGRGETVSDTAKVLSQYIDGIMIRTFSHADVEELAKESSIPVINGLTDDHHPCQALADLMTIYEETNTFKGIKLAYVGDGNNVCHSLLLASAKVGMHMTVATPVGYEPNEEIVKKALAIAKETGAEIEVLHDPELAVNEADFIYTDVWMSMGQEGEEEKYSLFQPYQINNELVKHAKQTYRFLHCLPAHREEEVTGKIIDGPQSIVFEQAGNRLHAQKALLVSLFKNVEEPS
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBL_SPAWA
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: GEP3_PICST
Sequence: MIRYSGFSVVRSCLSRTFSRNNSALSTAITSSLLTNLFPTCKSCGVRLQSSDPKGPGYYILEESKPAKRFVKSEDQVFAKYVNDLSLEDKKLLINEDSKKVSDSESRSESQDLSNEADIDSSLVNSLGNKDYYASEIKKVSQKDKFKLEEKYNDSVECVRCRDATYRSNFKNFSQQEYPLELLDNIMSRIPPHEQIVYIVNAQDFPMSINPKIFQYRSSNELKFIVNKADLLFKSINLSKNYGQTFFSDYLFHKYRVPKENVMVVSGTNYWDFDKVLDFVDDNSYLIGNVNCGKSTIIKGMLYTIDKSNKRKKFMSSRERTKMEKEQDMLINRASRMKAMTAGEKKKEKKRYEMLFRSKVGPGVSHIPGFTRGFIQIDLEDMDKTIYDVPGFVNSENQLIHHHDIYNKISSPKILKQIHKGVKVYDKGTYTSKYITAKGGQSLTIGGLFFLNFPQKSMYQLRNCINHDFHLFSNFSRAVYISSNLSKYPGMGSKFFIEHDDSSLKELRRFIIPPFHGSIDLVIQNLGHINIKPTGRKETNQPLILYLPPGVEAIIRLPITNYIAKTFTGRDAKGNPLRKENILTKGVLALQRYTAKYPFYSTLISANKGAEVSSELALILKSEATCEPVTDAEQERLVKQDFARIGEWATIARGVECNYNERTVVDERNKFDYWME
What is the function of this protein?
May be involved in the mitochondrial lipid metabolism.
What are the official names of this protein?
Genetic interactor of prohibitins 3, mitochondrial, Found in mitochondrial proteome protein 38.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PPZC_METRR
Sequence: MATDTAVTGAPETTELRLASGNGPVTRTVLRTPVRDALPSEVPLIDISPIFSTCVADRKAVARKIHDAATNIGFFYIQNHRVPSQDIDLAYSASQDFFRQEMEVKVEADAKDGPFDSGYRGPGTQRVNPTEGADLRETYSILYDPMLDPTVPDPANIPEPASRFLHLGRAPFESTATLPHFKDAFVRYFQACLVLARALTRAFALSLDLPESAFDGKVQYPDASLEINFYPPISTGHAVSAPGDADTRVSIGSHTDFLLFTILWQDSNGGLQVLNREGQWIRAIPVEGTFVVNIGDYLQRVTNDKYVSTVHRAQNFSGRERVSMPFFWGFGMHESCQVLRNCCGEDEKSKYDEVKCVDWVSRRLGNLFDLSDKG
What is the function of this protein?
2-oxoglutarate-Fe(II) type oxidoreductase; part of the gene cluster that mediates the biosynthesis of pyrrolopyrazines, secondary metabolites showing insecticidal activity (PubMed:30452111).  The single multifunctional NRPS ppzA is responsible for the biosynthesis of peramine (PubMed:30452111).  The condensation domain of ppzA is proposed to catalyze formation of a peptide bond between 1-pyrroline-5-carboxylate and arginine (By similarity).  The methylation domain of ppzA would catalyze the N-methylation of the alpha-amino group of arginine (By similarity).  The reductase domain is proposed to be responsible for reduction of the thioester and the cyclization to form an iminium ion resulting in release from the peptide synthetase (By similarity).  Deprotonation of this intermediate and oxidation of the pyrroline ring would give rise to peramine (By similarity).  This final oxidation to give the pyrrole functionality may be spontaneous (By similarity).  In Epichloe species that produce only peramine, the peramine synthetase gene is not localized in a gene cluster, in contrast to Metarhizium rileyi that contains additionnal pyrrolopyrazine biosynthesis genes (Probable).  The 2-oxoglutarate-Fe(II) type oxidoreductases ppzC and ppzD could be candidates for conversion of proline into an oxidized derivative to be used by the ppzA A1-domain as substrate (Probable).  The other ppz genes encode proteins predicted to derivatize peramine into more complex pyrrolopyrazine metabolites (Probable).
What are the official names of this protein?
2-oxoglutarate-Fe(II) type oxidoreductase ppzC, Pyrrolopyrazine biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: S12A6_MOUSE
Sequence: MHPPEATTKMSSVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSELSGATTSLATVALDPSSDRTSNPQDVTEDPSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKSPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGILQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHLDICSKTKEVDNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVISIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGNLNHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHLMEAEKVKGFCQLVVAAKLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNVSFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS
What is the function of this protein?
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (By similarity).  May contribute to cell volume homeostasis in single cells (By similarity).
What are the official names of this protein?
Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein.
Protein: IOLA_BACNA
Sequence: MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFETWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEALGEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHPEIKAISFVGSKPVGEYVYKKGSEHLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKVVTARFPAPDFN
What is the function of this protein?
Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.
What are the official names of this protein?
Malonate-semialdehyde dehydrogenase, MSA dehydrogenase, Methylmalonate-semialdehyde dehydrogenase, MMSA dehydrogenase, MSDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. IolA subfamily.
Protein: KUN5_TABYA
Sequence: MKVLSLIFVIFSVLVLFASAKDPVCDQPKAVRRCFAAFPKFYFNSSSGQCEGFIYGGCGGNENNFNTLEECNAKCA
What is the function of this protein?
Potent anticoagulant protein that inhibits the hydrolytic activities of all serine proteases tested (trypsin, thrombin, elastase, and chymotrypsin), with the highest efficacy on thrombin.
What are the official names of this protein?
Tabkunin 5, Serine protease inhibitor 5.
What are the subcellular locations of this protein?
Secreted.
Protein: RL2_LEPCP
Sequence: MAVVKVKPTSPGRRGVVKIVHKHLHKGKPEASLLEPQMQNAGRNNNGHITVRHKGGGHKHHYRVVDFRRNKDGIPAKVERIEYDPNRTAHIALICYADGERSYIIAPRGLEAGQTVLNGAEAPIKAGNTLPIRNIPVGSTIHCVEMMPGKGAQIARSAGTSVTLMAREGIYAQVRLRSGEVRKIHIDCRATIGEVSNEEHNLRQYGKAGAKRWLGIRPTVRGVAMNPVDHPHGGGEGRTGEGQAPVSPWNTLTKGYRTRNNKRTQTFIVSRRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: POHS1_ARATH
Sequence: MAGSLTASNRRRNAEDSSEIYRWTIGFARFVHYPSSPSPHPVLKPLGKREQYHSPHGTWLSASSSTVSLHIVDELNRSDVILSVKLGQKVLEEHYISKLNFTWPQMSCVSGFPSRGSRAIFVTYMDSANQIQKFALRFSTCDAALEFVEALKEKIKGLKEASTQNQKNKTRCDVSFQSDYNPSDAIIPRATQKEPNMVRPLNSYVPEMLPRIVYEAQYQKSETRSEVSFQSDYNPSIEIFPRATEEEPNMVRFFDSSVPEVLPRPEYEAGQALYPSQSTLNQIPSLPPSFTTLLSGCFPDSTLDAGQTTVKQNPDLKSQILKYMEDSSFQDMLQKVERIIDEIGGNWIT
What is the function of this protein?
Required for accurate chromosome segregation in meiosis.  Required for pairing to occur between homologous chromosomes.  Acts in early recombination steps and ensures pairing fidelity and proper repair of meiotic DNA double-strand-breaks.  Regulates recombination and pairing of homologous chromosomes during meiotic prophase by controlling transport of RAD50 from cytoplasm to the nucleus.  May affect pairing of the gene-rich fraction of the genome rather than preventing pairing between repetitive DNA elements.
What are the official names of this protein?
Protein POOR HOMOLOGOUS SYNAPSIS 1.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the cytoplasm during leptotene, zygotene and pachytene.
Protein: TSAD_LIGS1
Sequence: MDKKDNIILAFESSCDETSVAVVKNGNEILSNIVATQVASHQRFGGVVPEVASRHHIEQITYCIQDALDEANVDYEDLDAVAVTYGPGLVGALLVGVAAAKAIAFAHNLPLIPVNHMAGHIYAARFIGEIKFPALALLVSGGHTELVYMPEENKFQIIGETRDDAAGEAFDKVGRVMGMKYPSGKEIDELAKTGKDTFNFPRAMEKEDNFDFSFSGLKSAFINTVHHASQIGEKLDKADLATSFEQSVVDVLSSKTVKALGHFKVKQLILAGGVAANQGLRTRLDKELTAFKDVELLKAPLKLCGDNAAMIGAAGYVAFKHGVRADMTLNAEPSLEFEWMVEK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HKDC1_MOUSE
Sequence: MFAVHLVAFYFTKLKEDQIKKVDRFLYHMRLSDETLVDIMARFQAEMEKGLGKDTNPTASVKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVSQEGQQNVQMESQFYPMPNEITRGNGTELFDYVADCLADFMKTKNLTHKKLPLGFTFSFPCRQNKLEEGVLLSWTKKFKARGVQDTDVVNRLATAMKKHKDLDVDILALVNDTVGTMMTCAYDDPNCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYMGELVRLILLKMAKVGLLFGGAKSSALHTKGKIETQHVAAMEMSKEGLANTREILVDLGLEPSESDCIAVQHVCTIVSFRSANLCAAALATILTRLRENKKLARLRTTVGMDGTLYKTHPQYPKRLHKVVRRLVPNCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDKVLALFQLTREQLLGVRDKMRAELEYGLKKKTHSLATVKMLPTYVYGMPDGTEKGKFLALDLGGTNFRVLLVKIRRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFSFPCRQTCIDKGTLVGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTCGYEDPRCEIGLIAGTGSNVCYMEEMRNIELVDGDEGRMCVNTEWGGFGDNGCIDDIRTQYDKEVDEGSLNAGKQRYEKMTSGMYLGEIVRRILIDLTRQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQMCGAGMAAIVEKRREDQGLQHFKVTVGVDGTLYKLHPHFSRILQETVKELAPQCDVTFMLSEDGSGKGAALITAVAKRLQQPRKDI
What is the function of this protein?
Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (By similarity).  Has low glucose phosphorylating activity compared to other hexokinases (By similarity).  Involved in glucose homeostasis and hepatic lipid accumulation (PubMed:30543855).  Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (PubMed:25648650, PubMed:27459389).
What are the official names of this protein?
Hexokinase HKDC1, Hexokinase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion membrane; Peripheral membrane protein. Photoreceptor inner segment. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion.
Protein: HCP_NATTJ
Sequence: MSMKCFQCQETVKNQGCTVKGVCGKPDNVANLQDVLIYTLKGISFYAHEGRNLGVKDEEVDRFVMDNLFATVTNVNFSEQDFIDRIKQSFKIRDQIKEQVMLKYREKYGENLDNKVPSNATWYTEDELNFKTKGEEVGVHSSDNEDINSLRELLTYGIKGIAAYAHHAYTLNQKDDEIFAFMHKGLAATTDDSLSVDDLVSLVMECGKFGVNTMALLDKANTEAYGHPEPTQINIGVRNNPGILISGHDLKDMQELLEQTEGTGVDVYTHGEMLPANAYPAFKKYDHFVGNYGNAWWQQNEEFEKFNGPILMTTNCLVPPKDSYKDRVYTTGVVGFDGVTHIPEREAGESKDFSQIIEHAKKCAAPEELEQGEIPGGFAHNAVLSVADKVVEAVKNGDIKRFVVMGGCDGRHKSREYYTEFAKALPQDTIILTAGCAKYRYNKLDLGDIGGIPRVLDAGQCNDSYSLVVIAQKLAEAFELEDINDLPVSYNIAWYEQKAVTVLLSLLYLGVKKIYLGPTLPAFVSENVLNVLVDKFDMRPNSNVDEDLEKIMAGE
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAT_HV1V9
Sequence: MDPVDPNQEPWNHPGSQPRTACNNCYCKKCCYHCQLCFLKKGLGIYYGRKKRRQRRGTPKSLQDHQTLIPKQPLSRTSGDPTGPEK
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.