PharMolix/UniProtQA huggingface dataset:
Protein: NOTN_ASPVE
Sequence: MRAALLTLAFTALAAAADDATTTVGFFGGGEWENSNDDDSLPLIPSYTSIGASVVDVNAVETVLAISCLEGAATESCSINDPWTMTQGISSFSWYAEYTAFDWNPPVTATLDYNCAYENYTLSATCTYSMSYSGSSDGAETSTSFSTETSWDSVATYAALEVTGGLDKFNQPEATETPEGGAGFAGPIQAMVTAAPVLAAGLLASHASGAWRKGKILLIKPFKGILPRLARLEASVKSPNPYRNEPLTPNLDIRAPSSGQCNASLYTRHHPGCFDDDIDSLGQVVLSSQVLGVFFNRLCRVEFVCPDAQFACRECQPVFVDIHCNDVPSTKLPCCRGRKQTNRPCPKNKHILAWLELCKAEAMHRDSKGLKDNAFVKPYVVGELVAEVPRQAEKGRQRAMDNIARSRNCGKGHVRT
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of notoamide, a fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2. 2. 2]diazaoctane core (PubMed:23213353).  The first step of notoamide biosynthesis involves coupling of L-proline and L-tryptophan by the bimodular NRPS notE', to produce cyclo-L-tryptophan-L-proline called brevianamide F (Probable).  The reverse prenyltransferase notF' then acts as a deoxybrevianamide E synthase and converts brevianamide F to deoxybrevianamide E via reverse prenylation at C-2 of the indole ring leading to the bicyclo[2. 2. 2]diazaoctane core (PubMed:22660767) (Probable).  Deoxybrevianamide E is further hydroxylated at C-6 of the indole ring, likely catalyzed by the cytochrome P450 monooxygenase notG', to yield 6-hydroxy-deoxybrevianamide E (Probable).  6-hydroxy-deoxybrevianamide E is a specific substrate of the prenyltransferase notC' for normal prenylation at C-7 to produce 6-hydroxy-7-prenyl-deoxybrevianamide, also called notoamide S (Probable).  As the proposed pivotal branching point in notoamide biosynthesis, notoamide S can be diverted to notoamide E through an oxidative pyran ring closure putatively catalyzed by either notH' cytochrome P450 monooxygenase or the notD' FAD-linked oxidoreductase (Probable).  This step would be followed by an indole 2,3-epoxidation-initiated pinacol-like rearrangement catalyzed by the notB' FAD-dependent monooxygenase leading to the formation of notoamide C and notoamide D (Probable).  On the other hand notoamide S is converted to notoamide T by notH' (or notD'), a bifunctional oxidase that also functions as the intramolecular Diels-Alderase responsible for generation of (-)-notoamide T (Probable).  To generate antipodal (+)-notoaminide T, notH (or notD) in Aspergillus strain MF297-2 is expected to catalyze a Diels-Alder reaction leading to the opposite stereochemistry (Probable).  The remaining oxidoreductase notD' (or notH') likely catalyzes the oxidative pyran ring formation to yield (-)-stephacidin A (Probable).  The FAD-dependent monooxygenase notI' is highly similar to notB' and is predicted to catalyze a similar conversion from (-)-stephacidin A to (+)-notoamide B via the 2,3-epoxidation of (-)-stephacidin A followed by a pinacol-type rearrangement (Probable).  Finally, it remains unclear which enzyme could be responsible for the final hydroxylation steps leading to notoamide A and sclerotiamide (Probable).  The fonction of notN' in the notoamide biosynthesis has not been determined yet (Probable).
What are the official names of this protein?
Notoamide biosynthesis cluster protein N'.
Protein: PPR72_ARATH
Sequence: MGKAQIIQHQARRILSQSNRNCLFRRSYETLPAANQTLPSRIKTDINQKASIIPLLEQWRKQGYEVNPSHLRGLIKNLSDCKNFTTALEASKWMFKHSVFDNFPEDCAAQLHLVNTVLGLEEAEKMFKNIPEKMRDYSVLLSSYTKPVRTVDKAEATFKKMRELGFLLKPYLFNSMICLYGQLQRLDMVEKLLYKLKKNNMEVGSLKVNNVSRVYANINAMEKFKTWVSKEGIELERDTIVAMAKAYHRAGSIEKAR
What are the official names of this protein?
Putative pentatricopeptide repeat-containing protein At1g43010.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: Y1665_METJA
Sequence: MFRPEEIIETIKMIKMENLDLRTVTLGLSLRDCVSKDLDELKENIYNKITSSAENLVETAERISEKYGIPIVNKRIAVTPISLVIGGAIKDLDKEEQIKACVEVGEVLDKAAKKVRVDFLGGYSALVHKDATKEDRALIDSIPFMMEKTERVCSSVNVASTKTGINMDAVKRMGEIIKETAFRTEKAIGCAKLVVFANAPEDNPFMAGAFHGVGEGDKVINVGVSGPGVVRAVIEKLPDADFGTLANEIKKVAFKITRVGELIGREVSKELGVKFGVVDLSLAPTPARGDSIANILEAMGLEKCGTHGSTAALALLNDAVKKGGAMATSYVGGLSGAFIPVSEDSGMVEAVEAGALTLEKLEAMTCVCSVGIDMVAIPGDTPASTISAIIADEMAIGVINNKTTAVRIIPVPGKKAGEYVDYGGLLGKAPIMEVNKYSSEKFIKRGGRIPAPLQALTN
What are the official names of this protein?
UPF0210 protein MJ1665.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: ISPT_CALS4
Sequence: MIFFNEEKLIKKLDKTRLPQHVGIIMDGNGRWAQKRGMPRVYGHKAGVNAVREVIRSCRELGIKYLTLYAFSTENWKRPKEEVDFLMDLLVEYLSKEVDELNKNNVVVKFIGDISRLPEKCQIEIEKAQKLTEKNTGLVVNIALNYGGRDEIVKATQNICKKVLNRELSPEDITEDTITQHLYTASQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFKKRHLIEALLYYQTRKRRFGGV
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: ITBP1_PONAB
Sequence: MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNSNSDTCAEFRIKYVGAIEKLKLSEGKDLEGPLDLINYIDVAQQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQYDVLHRHALYLIIRMVCYDDGLGAGKSLLALKTTDASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSEKP
What is the function of this protein?
Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1.  Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis.  Stimulates cellular proliferation in a fibronectin-dependent manner.  Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner.  Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin.  Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool.  Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin.  Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis.  Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway.  Promotes transcriptional activity of the MYC promoter (By similarity).
What are the official names of this protein?
Integrin beta-1-binding protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in an integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin-rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen (By similarity).
Protein: DNTAA_BURSR
Sequence: MELVVEPLNLHLNAETGSTLLDVLRSNEVPISYSCMSGRCGTCRCRVIAGHLRDNGPETGRPQAGKGAYVLACQAVLTEDCTIEIPESDEIVVHPARIVKGTVTAIDEATHDIRRLRIKLAKPLEFSPGQYATVQFTPECVRPYSMAGLPSDAEMEFQIRAVPGGHVSNYVFNELSVGASVRISGPLGTAYLRRTHTGPMLCVGGGTGLAPVLSIVRGALESGMSYPIHLYFGVRSEQDIYDEERLHALAARFPNLKVNVVVATGPAGPGHRSGLVTDLIGRDLPNLAGWRLHPVWRSGHGRGPEPARCSPRHSTRAHPCRCVLSQRRLSEGTMRTQFNPRIPSHE
What is the function of this protein?
Component of the 2,4-dinitrotoluene dioxygenase (DNTDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into 2,4-dinitrotoluene (DNT) to form 4-methyl-5-nitrocatechol (MNC) and nitrite.  Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (DntAb).  Also able to convert naphthalene to cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene.
What are the official names of this protein?
2,4-dinitrotoluene dioxygenase system ferredoxin--NAD(+), reductase component, Ferredoxin--NAD(+) reductase (2,4-dinitrotoluene dioxygenase ferredoxin-specific).
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase component family.
Protein: HPRT_METFA
Sequence: MLLEETLKSCPIVKRGEYHYFIHPISDGVPVVDPKLLREVVTRIIKIGNFEDVDKIVTAEAMGIPLVTTLSLYTDIPYVIMRKREYKLPGEIPVFQSTGYSKGQLYLNGIEKGDKVVIIDDVISTGGTLIAIIEALKKAGAEIKDIICVIERGEGKKIVEEKTGYKIKTLVKIDVVDGKVVIL
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
What are the official names of this protein?
Hypoxanthine/guanine phosphoribosyltransferase, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_PHOLL
Sequence: MANKWRCSIALAVLSLTGCAYIPQKPLVEGATTAAPSVATAPVPNGAIFQVVQPVYYGYQPLFEDRRPRNIGDTLTITLQENVSASKNSSANASRNGKNTFSAALTPRFLKGLIGGDKTDLDMEAENTFGGKGGANANNTFKGTITVTVDRLLANGNLHVVGEKQIAINQGTEFIRFSGVVNPRTINANNTVSSNQVADARIEYVGNGYINEAQNMGWLQRFFLNVAPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: LYSZ_PYRIL
Sequence: MIVIKVGGSVVCKDVSKVIQNLPKYADRAIIVHGGGCLVNEMLKRLGIEPKFLTHPGGLTSRYTDLETLKVFVMAMSWINKQIVASLHALGVEALGLTGADLGVVRAKRKEKVLIVDERGRQRVVDGGYVGRVVHIAADRLKPPPLKVLSPIAVSEKGELLNVDGDQLAFDVAKAVGARQLVLLSDVDGLIIGGRVVPHLTAEEAEELVKSEEVRGGMKRKLLMAAEAAKSGIEVVISNGLVENPIDVALNGSGTHIVKNL
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.  Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
What are the official names of this protein?
Putative [LysW]-aminoadipate/[LysW]-glutamate kinase.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. LysZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_LEMMI
Sequence: MQNVTDSFVSLGHWPSAGGFGFNTDILATNPINLSVVLGVVIYFGKGVLNDLLDNRKQRILSTIRNSEELRQAAIEQLEKARARLRKVETEANDYRVNGYSEIEREKQNLIKATSENLERLENYKNETLLFEQQRAINQVRQRVFQQALQGALGTLNSCLNSELHFRTISANIGILGVMEE
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ICAM1_HUMAN
Sequence: MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
What is the function of this protein?
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
What are the official names of this protein?
Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. ICAM family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: THYX_EHRRG
Sequence: MLVLSIRIKVWQTMESEITKRIVVPELEDILYKEHKVLDKGFVRLVDYMGSDESVVQAARISYGRGTKSVSQDAALINYLMRHSHTTPFEMCEIKFHIKLPIFVARQWVRHRTANVNEYSARYSVLDHEFYIPELDHVATQSEDNAQGRGNSLSNEDAQYVTDLLKRDSDMVYETYNKFLIKGVSREISRISLTLNYYTEWYWKIDLHNLLHFLRLRSDVHAQYEIRVYAETMLEIVKKWVPLTYAAFVEYCLESQSFSKSALSVVKKLIAGEDVAREDTGIGKREWRELMDVLADK
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: UD2B4_HUMAN
Sequence: MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD
What is the function of this protein?
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867).  Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867).  Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867).
What are the official names of this protein?
UDP-glucuronosyltransferase 2B4, UDPGT 2B4, UGT2B4, HLUG25, Hyodeoxycholic acid-specific UDPGT, UDPGTh-1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: NADE_SHEB8
Sequence: MKAQILREMKVLTAIEPEFEVQRRVAFIKTKLKEARSKALVLGISGGVDSSTAGRLCQLAVDSLNHENSQGGYQFIAVRLPYQIQKDEHEAQLACQFIQPSKLVTVNVHQGVDGVHSATVAALAEAGLPLPDVAKVDFVKGNVKARMRMIAQYELAGLVGGLVVGTDHSAENITGFYTKWGDGACDLAPLFGLNKRQVRQLAAYLGAPKSLVHKAPTADLEDNKPLLEDEVALGLTYAQIDDFLEGKDVGKAVEDKLIGIYKATQHKRQPIPTIYD
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: SYL_UREPA
Sequence: MYNHNKIEKKWQKYWLDNKTFKFVDNPNNPKKFYVLDMFPYPSGKGLHVGHPKGYTATDVISRFKRLNGYDVLHPIGWDAFGLPAEQYALETNNHPHTFTQQNIKIFRKQLQMIGFDFDYDKEVDTTDPQFYQWTQWIFVQLYKHNLAEIQDIDVNWCENLGTVLSNEEVVLNDKNERVSERGGHPVVRKPMKQWVLKIVDYADKLLDGLNEVEFSESLKSLQRNWIGKSIGTSVQFKIKDSLLTLDVFTTRIDTIYGVQYLVVAPEHPILKSITSEQQINVVQSYIEQTKKISDLDRIADTNKTGVFSGAYAINPINQEIIPIWVSDYVLMNFATGAVMGVPAHDERDYAFAKKYALPIKSVIDTKQKLPYAGDGLHINSAMINGLNIKQSQNVLNDYLIKNHLGKKVANYKLRNWIFSRQRYWGEPFPVLFDENNQIKIIEDLPVLLPNLNEFKPSKTGESPLANAQEWLYVEIDGKKYRRETNTMPQWAGSSWYFLAYILKNEDGSYTPLNSEEAKKRFAKWLPVDVYIGGQEHAVLHLLYSRFWHRFLYDIGVVPTKEPFYKVINQGMILGENNEKMSKSKGNVINPDDIIASHGADTLRIYEMFMGPLTASLPWNPDGLDAMRKWLDRVYRLYHNLSELEVVEDLNKLNEEIIIAYHTLIKNYTKAINEQAFNIAISEMMVFVNVLYKNKVINYELLDNFLILLSCYAPHLAEELYSLNHSESVCLQKMPIYDEQKIIAQNITIPIQINGKLKHTINVLRDTNAEELVNLALACEQVKQEIGDQPIKKQIVVVNKIINFVI
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSSK4_MOUSE
Sequence: MGKGDTSETASATPAYRSVMEEYGYEVGKIIGHGSYGTVYEAYYTKQKVMVAVKIISKKKASEDYLNKFLPREIQVMKVLRHKYLINFYQAIETTSRVYIILELAQGGDVLEWIQRYGACAETLAGKWFSQMALGIAYLHSKGIVHRDLKLENLLLDKRENVKISDFGFAKMVPSSQPVHSSPSYRQMNSLSHLSQTYCGSFAYACPEILLGLPYNPFLSDTWSMGVILYTLVVARLPFDDTNLKKLLRETQKEVTFPANLTISQECKNLILQLLRQSTKRATILDVLRDPWMLKFQPEQPSNEIRLLEAMYQPTSSAKRHQSLEITT
What is the function of this protein?
Catalytically inactive.
What are the official names of this protein?
Testis-specific serine/threonine-protein kinase 4, TSK-4, TSSK-4, Testis-specific kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=In spermatozoa, present in the sperm head and in the flagellum.
Protein: NTPPA_LEPIC
Sequence: MIVLRSKSPRRKQILESLDLDFRIESEDIDESSLKDEHPLEYLKRISLSKLGTRSKDELLISCDTIVVQENSILQKPENFSQAIEMLERLSGKTHIVYSGLGIYYNRLEQFAFDSSKVHFHTWNKEQIKKYIERYSPFDKAGSYGVQDIEGPVQSFEGSYTNILGFPIRMFFQYHELWKKYLKGNQA
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL729_MIMIV
Sequence: MSEDKNYIIDPLTALCKVALLHFMPDKTKLAINHHVLYIQGYSYYQWLERMKNGDSRVDISNLNMPIIKAVKWYIIDSEDKAELDSETCNNILIITKYTIKGLIKLQQTYCTDNAIKIILQYLINLLRDAIDNNWNDDNCVKIDNHHNILSDKIKKNFESQTISAISKILTDAERMSGSQEDVNALIDCAHKLLINRDTVFVRMMKEVNTHL
What are the official names of this protein?
Uncharacterized protein L729.
Protein: YBBA_ECOLI
Sequence: MPAENIVEVHHLKKSVGQGEHELSILTGVELVVKRGETIALVGESGSGKSTLLAILAGLDDGSSGEVSLVGQPLHNMDEEARAKLRAKHVGFVFQSFMLIPTLNALENVELPALLRGESSAESRNGAKALLEQLGLGKRLDHLPAQLSGGEQQRVALARAFNGRPDVLFADEPTGNLDRQTGDKIADLLFSLNREHGTTLIMVTHDLQLAARCDRCLRLVNGQLQEEA
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YbbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: FTSH2_ALKMQ
Sequence: MRKFFRGASFYILAFIIILFIVQNFGRPTQEIDELDFSEFYRALVNDRVTEAHLVERSVEGIWVNNNNEEMSYRSFVPEVFSEERLTLIIEEKIDQEGLRVSAAPPPTTPWFIELLPSIFMVLIFIVFWFVFMQQSQGGGNRVMSFGKSKAKLHKDDEGKRITFDDVAGLDEEKAEVEELVDFLKNPKKYIELGARIPKGILMIGPPGTGKTYLTKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKSAPCIIFIDEIDAVGRKRGAGLGGGHDEREQTLNQLLVEMDGFGINEGIIIVAATNRPDILDPALLRPGRFDRQVMVGAPDIKGREQILQVHAKGKPLDEDVNLKVLARRTPGFTPADIENLMNEAALLTARKNEKKIKMETVEEAITKVIAGLEKKSRVISEKERKLTAYHEAGHAVVAKLLTHTDPVHQVTIIPRGRAGGFTMTLPTEDKYYVTKTEMQEHIVHLLGGRVAEKLVLHDISTGASNDLQRVSSIARAMVTQYGMSDKLGSMTFGDGDSEVFLGRDFTSKHNYSEEVAAEIDQEIRKFVEEAYMLTEKLLTENMDKLHVIAQALLKLETLDADAFEMIFTGEIVIGKDDQLEDIQPKLNVVKAKKRAAEAAEEAEVAKEDAKKQDVKVSLKKQEKEELIEVSSDKEEEKDNQDDQDNEENRKEE
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: TI222_ARATH
Sequence: MAANDSSNAIDIDGNLDSDSNLNTDGDEATDNDSSKALVTIPAPAVCLFRFAGDAAGGAVMGSIFGYGSGLFKKKGFKGSFADAGQSAKTFAVLSGVHSLVVCLLKQIRGKDDAINVGVAGCCTGLALSFPGAPQALLQSCLTFGAFSFILEGLNKRQTALAHSVSLRHQTGLFQDHHRALPLSLALPIPEEIKGAFSSFCKSLAKPRKF
What is the function of this protein?
Together with HP30-1 and HP30-2, triggers the import and insertion of transit sequence-less multi-pass transmembrane proteins (e. g.  CEQORH) into the chloroplastic inner membrane.
What are the official names of this protein?
Chloroplastic import inner membrane translocase subunit TIM22-2, Hypothetical outer plastid envelope protein of 20 kDa, Hypothetical protein 20.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane; Multi-pass membrane protein.
Protein: DEOC2_YERPS
Sequence: MTDLTACAHLNDYAKRALSLMDLTTLNDDDTDEKVIALCHQAKSPAGNTAAICIYPRFIPVARKALREQGTPEIRIATVTNFPHGNDDVAIALAETRAAIAYGADEVDVVFPYRALMAGNDKIGFELVKTCKEACAAANVLLKVIIETGELKQAHLIRQASEIAIKAGADFIKTSTGKVPVNATLESADIMIRTIRELGVGETVGFKPAGGVRTAEDAAQFLQLADQLMGEGWADARHFRFGASSLLASLLTTLGHQSNANSSGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase 2, DERA 2, 2-deoxy-D-ribose 5-phosphate aldolase 2, Phosphodeoxyriboaldolase 2, Deoxyriboaldolase 2.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG122_VAR67
Sequence: MNFYRSSIISQIIKYNRRLAKSIICEDDSQIITLTAFVNQCLWCHKRVSVSAILLTTDNKILVCNRRDSFLYSEIIRTRNMSRKKRLFLNYSNYLNKQERSILSSFFSLDPATIDNDRIDAIYPGGILKRGENVPECLSREIKEEVNIDNSFVFIDTRFFIHGIIEDTIINKFFEVIFFVGRISLTSDQIIDTFKSNHEIKDLIFLDPNSGNGLQYEIAKYALDTAKLKCYGHRGCYYESLKKLTEDD
What is the function of this protein?
Decapping enzyme that remove the protective 5'-cap from both host and viral mRNAs to commit transcripts for decay by the cellular exonuclease XRN1.  Preferentially targets spliced mRNAs and since all viral genes are intronless, it preferentially targets host over viral transcripts.  Acceleration of the turnover of cellular transcripts promotes the shutoff of host protein synthesis and therefore diminish the magnitude of antiviral response.
What are the official names of this protein?
mRNA-decapping protein OPG122.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.