PharMolix/UniProtQA huggingface dataset:
Protein: ARLY_METFK
Sequence: MTEKSNHLNQPSSKTWSGRFNEPVAELVKQYTASVGFDYRLAEYDIQGSLAHARMLGAQGIISQDDVAQIEQGLGEIMDEIRNGEFAWLLDLEDVHLNIEKRLTDKIGDAGKRLHTGRSRNDQVATDIRLWLRSMVDDALSRLRKLQASLVALAEQHADTVMPGFTHLQVAQPVTFGHHLLAYFEMLQRDAERLVDARKRINRLPLGAAALAGTSYPIDRERVAHELGFEAVCENSLDAVSDRDFAIEFTAAAALIMTHLSRLSEELILWSSPRFGFIDIADRFCTGSSIMPQKKNPDVPELVRGKTGRVNGHLVALLTLMKSQPLAYNKDNQEDKEPLFDTVDTLLVTLEIYADMLRGIKVNKDAMRLAAAEGFATATDLADYLVKKGMPFRDAHEVVALAVRHAVEQGCDLADLSLSQLQKFSPEIAEDVYGVLTLEGSLASRNHRGGTAPAQVREALKRARALLG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPR6_SCHPO
Sequence: MRILGSLPNNIRKCTFKLILQKRYSHTDILKELLYDISDSQKFIPSASPIASNLLRVSSYGKLSSLFIEYSKARSKKEFDQLRTSDFQSILRSVVCPKNGKNIRHRDRDLVSLQIKLILQDADRLGIQFNIVDYTHILRVAMYTGNKHILEYIVARVKEKRIRPSVDYFNAILGVIGGNRWSLSKFQSPAFRGSPVTEPVSGKMLDMIEVDFPNYDLVPNSTTYDYLMVGLSRDGKIREIYDLIDTVWGINENSSSKKVDCGNVTFPTHHTVFSIISALGYLGDVSSAVSLSRKLTSVYKINFPELAWRYIIYWSIASLQFRAPAGHARIKNIELFIRLYSQMYRHCVPIIEIYDTSIKFYMKHGRFGLLEKVCESWTKQFLGSLEKQNNEVKKKHLQLLEKQISKLMRYAETERPHDTKRVSVKWSNVLNQIHSSVGDPAKP
What is the function of this protein?
Mitochondrial RNA-binding protein required for the stability of the atp9 mRNA.
What are the official names of this protein?
Pentatricopeptide repeat-containing protein 6, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EFGM_NEMVE
Sequence: MGIITLLANRRGLHAILSNAQRIVGCRFVSSSIIPDASRLRNIGISAHIDSGKTTLTERLLFYTGRISHMHEVKGKDNVGATMDSMELERQRGITIQSAATYVNWKDHNINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYNVPCIAFINKLDRMGANHNRVLSQLRAKLNHNAALLQLPVGLEGNNTGVVDIIRWKAYYFDGDNGEIVREDVIPEDMVDECRKRRQELIEVVADVDPELGDLFLEEVKPSESQIIAAIRRATIERTFTPVFVGSALKNKGVQPLLDGVLDYLPNPTEVKNYALDAESLDTKVLMDSRRSGEAPFVGLAFKLEAGRYGQLTYLRVYQGALKRGGFIVNTRTGKRVKVPRIVRMHSDIMEDIQEGYAGDICALFGIECASGDTFTAEGAPLVSMESIFVPEPVISLAVEPKNKNDLDQFSKAINRFTREDPTFRVRFDDESKETIISGMGELHLDVYTERMRLEYNCPVICGKPKVAFRETIGKEASLDFRPKSRVAAAGQYGKVVGKIEPMPPESITKNEFVDATVGMNIPKNFIPAIEKGFYEACERGFITGHKVAGVRFVLEDGAAHAVDSSEMAFRMATIGAFREAFNKAAPMILEPIMSVEVNAPQEFQGTVIAGVNRRHGQVTGTDANEGYFTLFAEVPLNDMFGYATELRSQTQGKGEFTMEYCRYLPALAQVQAELMDRFNVEKLKKAKR
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PSBZ_ATRBE
Sequence: MTLAFQLAVFALIATSLILLISVPVVFASPDGWSSNKNVVFSGTSLWIGLVFLVGILNSLIS
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: GLNK2_HALMT
Sequence: MSDADLPNDGGIKLVMAIIRPDKLADVKTALAEVGAPSLTVTNVSGRGSQPAKKSQWRGEEYTVDLHQKVKVECVVADTPAEDVADAIADAAHTGEKGDGKIFILPVENAIQVRTGKTGRDAV
What is the function of this protein?
Involved in the regulation of nitrogen metabolism (PubMed:21265784, PubMed:23420616).  Regulates the activity of its targets by protein-protein interaction in response to the nitrogen status of the cell (PubMed:23069245).  Increases the activity of the glutamine synthetase 3 in the presence of 2-oxoglutarate (PubMed:23069245).  May regulate the activity of the ammonia channel Amt2 via direct interaction (By similarity).
What are the official names of this protein?
Nitrogen regulatory protein GlnK2.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK1_METAC
Sequence: MHWADVIAEDVLNKSGKHLVATGITPSGHIHIGNMREVVTADAAYRALLDMGADARLIYIADNYDPLRKVYPFLPESYAEHVGKPISEVPCPCGDCANYAEHFLKPFIEALRRLGINPEVLRADEMYRAGLYTEAIKTALAKRDEIAKILEEVSGKTVAEDWSPFNPRCNECGKITTTKVAGFDLEAETVDYVCACGHSGTVPMAGGGKLTWRVDWPARWAVLGVTVEPFGKDHASKGGSYDTGKRIVREIYGHEPPFPIVYEWIMLGKRGAMSSSTGVVVSISDMLEVVPPEVLRYLIIRTKPEKHIQFDPGQPLLNLVDEYERLRDKFRENDPSLGDFEKRIYELSRATGICHPEIPFKQMVTIYQVARGDFEQVLKIVKRSGFSTENEKCIRELADNVSRWLELYAPPFAKFSVKEKVPVQTATLSELQKAFLGAFADLIETKGKISGEEYHMLVYSAKDEGSELNRLIAQKVNVPVPQVDPKDLFKAIYTSILGQSSGPKAGWFLSSFEKGFLITRFREASTYNPEKSS
What are the official names of this protein?
Lysine--tRNA ligase 1, Lysyl-tRNA synthetase 1, LysRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_CORDI
Sequence: MTSPMTSKDSKLTLAEKVWRDHVVSQGEGDQPDLIFIDLQLLHEVTSPQAFDGLRMAGRTLRHPELHLATEDHNVPTEGIHNGSLLEINDLVSRTQVETLRKNCEEFGVRLHAMGDKKQGIVHQVGPQLGATQPGMTIVCGDSHTSTHGAFGAMAFGIGTSEVEHVMATQTLSLKPFKTMAINVTGELQPGVTAKDLILAVIATIGTGGGQGHVIEYRGEAIEKLSMEARMTVCNMSIEAGARAGMIAPDETTFDYIKGREMAPTGQDWDDAVAYWKTLPTDEGAEFDTEITIDGSAITPFITWGTNPGQGLPLSSVVPSPEDFPGDNEKVAAEKALAYMGLTPGTPLRDIAIDTVFLGSCTNARMDDLRIAADILRGRSIADSVRMMVVPSSTMIKEQAEAEGLDKIFIEAGAQWRTAGCSMCLGMNPDQLTPGERCASTSNRNFEGRQGPGGRTHLVSPAVAAATAIKGTLASPADLD
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: PLSC_LIMAL
Sequence: MAKTRTSSLRNRRQLKTAVAATADDDKDGIFMVLLSCFKIFVCFAIVLITAVAWGLIMVLLLPWPYMRIRLGNLYGHIIGGLVIWLYGIPIEIQGSEHTKKRAIYISNHASPIDAFFVMWLAPIGTVGVAKKEVIWYPLLGQLYTLAHHIRIDRSNPAAAIQSMKEAVRVITEKNLSLIMFPEGTRSGDGRLLPFKKGFVHLALQSHLPIVPMILTGTHLAWRKGTFRVRPVPITVKYLPPINTDDWTVDKIDDYVKMIHDIYVRNLPASQKPLGSTNRSK
What is the function of this protein?
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.  This enzyme uses erucoyl-CoA as an acyl donor.
What are the official names of this protein?
1-acyl-sn-glycerol-3-phosphate acyltransferase, 1-AGP acyltransferase, 1-AGPAT, Lysophosphatidic acid acyltransferase, LPAAT.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BX9_MAIZE
Sequence: MASSRTGAGAGGRVVVFPFPFQGHFNPVMRLARALHARGLAITVFHSGALDPADYPADYRFVPVTVEADPKLLASEDIAAIVTTLNASCDAPFRARLSALLAAEGRDSVRCVFTDVSWNAVLTASSDLGVPALGMMTASAASLRDYMAYRTLIDKGYLPVKEERKEDPVPELPPYLVKDLLRVDTSDLEEFAELLARTVTAARRASGLIFNTFPLIETDTLAEIHKALSVPVFAVAPLNKLVPTATASLHGVVQADRGCLQWLDTQQPGSVLYVSFGSMAAMDPHEFVELAWGLADSKRPFVWVVRPNLIRGFESGALPDGVEDEVRGRGIVVAWAPQEEVLAHPAVGGFLTHNGWNSTVEAISEGVPMVCCPRHGDQFGNMRYVCDVWKVGTELVGEQLERGQVKAAIDRLFGTKEGEEIKERMKEFKIAAAKGIGIGVDVDETASPRTDLTDLVDLIKSF
What is the function of this protein?
Glucosyltransferase involved in the last step of benzoxazinoid glucoside biosynthesis.  Catalyzes the glucosylation of hydroxamic acids utilizing UDP-glucose as glucose doner, reducing the toxicity of these natural insecticides for storage.  Can use DIMBOA and DIBOA as substrates, HMBOA (2-hydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) and HBOA (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one) with a lower efficiency, but not indole acetic acid or quercitin.
What are the official names of this protein?
DIMBOA UDP-glucosyltransferase BX9, 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase BX9, Protein BENZOXAZINLESS 9.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: ATPA_GLUDA
Sequence: MMEIRPAEISDILKQQIATFDTPVDIAETGTILSVGDGIARVYGLQNVQAGEMVEFPGSGQRGMALNLENDNVGVVIFGDDADMREGDTVSRTGAVVEVPTGKALLGRVVDGLGNPIDGKGPLVGDVVMKRADVKAPGIMPRQSVGEPMQTGIKAIDALVPIGRGQRELIIGDRQTGKTAILIDTIVAQKSVNALGDDKKSLYCIYVAIGQKRSTVAQLVRTLEETGAMEYSIVVAATASDPAPMQYLAPYAACAMGEYFRDNGMHALIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMSDEYGAGSLTALPVIETQAGDVSAYIPTNVISITDGQVFLETDLFYRGIRPAVNVGGSVSRVGSAAQIKAMKQVAGKIKLELAQYREMAAFSQFASDLDPATQKQLARGARLVELLKQPETSPLAVEEQVCVLFAGTRGFIDAVPVDKVSSYERQLLAELHTGGKEILESIRTERQITKDNETRLTDFLTSFGRQFAG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PTAL_PESFW
Sequence: MKHIVIIGGGFAGVSTAHRFLKNVGKSTTAPYKVTLVSRDSHFFWNIAAPRGIIPGQIPEEKLFQPIAEGFSQYGPDKFEFVLGTATDLDVGGKTLVVDVDGKATRISYDYLIIGSGSRTKIPGPFKSDGSTDGVKQTIHDFQERVKAAKTIVVVGAGPTGVETAGELAFEYGTSKKIILISGGPTVLENRPASVTKTALKQLETLNVDVRVNTKAKDPVTLPDGKKELTLSGGEKLVVDLYIPTFGVLPNSSFVPSQYLDSNGFVQVDQYFQVKGAEGVFAIGDVSDSEAPQFWFVEKQSVHIAKNLILSLSGKAPTPYKASATGMMGLQIGKNSGTGHFGNFKLPGFLVKTIRKTLFVENLPKTVDGSML
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes (PubMed:24302702).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS ptaA (PubMed:24302702).  As the ptaA protein is TE/CLC domain-deficient, hydrolysis and Claisen cyclization of the polyketide could be catalyzed by ptaB containing a beta-lactamase domain (PubMed:24302702).  The ptaB protein might hydrolyze the thioester bond between the ACP of ptaA and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrated to form endocrocin anthrone (PubMed:24302702).  Endocrocin anthrone is then converted to endocrocin, catalyzed by the anthrone oxygenase ptaC (PubMed:24302702).  Spontaneous decarboxylation of endocrocin occurs to generate emodin (PubMed:24302702).  An O-methyltransferase (ptaH or ptaI) could methylate emodin to form physcion (PubMed:24302702).  PtaJ could then catalyze the oxidative cleavage of physcion, and rotation of the intermediate could then afford desmethylisosulochrin (PubMed:24302702).  PtaF, a putative NADH-dependent oxidoreductase, might also participate in the oxidative cleavage step (PubMed:24302702).  Desmethylisosulochrin is then transformed by another O-methyltransferase (ptaH or ptaI) to form isosulochrin (PubMed:24302702).  Chlorination of isosulochrin by ptaM in the cyclohexadienone B ring then produces chloroisosulochrin (PubMed:24302702).  PtaE is responsible for the oxidative coupling reactions of both benzophenones isosulochrin and chloroisosulochrin to RES-1214-1 and pestheic acid respectively, regardless of chlorination.
What are the official names of this protein?
Oxidoreductase ptaL, Pestheic acid biosynthesis cluster protein L.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
Protein: AROB_PECAS
Sequence: MERITVTLGERSYPITIAAGLFDDPASFMPLKAGDQAMLVTNQTLAPLYLDCVRGVLENHGVHVDQVILPDGEQYKSLTVLDQVFTALLAKPHGRDTTIVALGGGVIGDLAGFAAASYQRGVRFLQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPVSVVIDLDCLKSLPARELSSGLAEVIKYGIILDRDFFLWLEENIEAVRELQHDALAYCIRRCCEIKAAVVAADERENSMRALLNLGHTYGHAIEAEMGYGNWLHGEAVAAGMVMAAHTARRLGQFSDSDVERVKSLLVRAGLPVNGPTQMTPESYLPHMMRDKKVLAGELRLVLPTAIGQSEVRGGVAHDMVLASIADCLA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_POLNA
Sequence: MRIALGISYSGSAYEGWQSQLSGKTVQDKLELALSRFAVQPIRVMCAGRTDAGVHALMQVVHFDTPLQRETSSWVRGTNAFLPSDIAVQWAQPVPDEFHSRASAIARRYAYVVLESPVRPSVEAGRVGWVYRPLDGDAMRQAALHLMGEHDFSSFRAAQCQAKSPVKTMSRIEISQRAGPGSRYWRFEFEANAFLHHMIRNIMGCLLAIGQGNHPPEWLAEVVAARRRDAAAPTFSPDGLYFLGPVYEERHGLPSRTAAYDWLP
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: H2A_STRPU
Sequence: MSGRGKSGKARTKAKTRSSRAGLQFPVGRVHRFLRKGNYAKRVGGGAPVYMAAVLEYLTAEILELAGNAARDNKKSRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTAKSS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A, embryonic.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: Y956_ARCFU
Sequence: MNFIESFDMDDEEKEKLLEKLASQQLRADYRKALGSEHKRRYMDMEIEKIFKKGKKDER
What are the official names of this protein?
Uncharacterized protein AF_0956.
Protein: R9BP_HUMAN
Sequence: MAREECKALLDGLNKTTACYHHLVLTVGGSADSQNLRQELQKTRQKAQELAVSTCARLTAVLRDRGLAADERAEFERLWVAFSGCLDLLEADMRRALELGAAFPLHAPRRPLVRTGVAGASSGVAARALSTRSLRLEAEGDFDVADLRELEREVLQVGEMIDNMEMKVNVPRWTVQARQAAGAELLSTVSAGPSSVVSLQERGGGCDPRKALAAILFGAVLLAAVALAVCVAKLS
What is the function of this protein?
Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction.  Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform.  Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place.  Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale.  It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity).
What are the official names of this protein?
Regulator of G-protein signaling 9-binding protein, RGS9-anchoring protein.
What is the protein family that this protein belongs to?
Belongs to the RGS7BP/RGS9BP family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein.
Protein: YCIC_ECO8A
Sequence: MSITAQSVYRDTGNFFRNQFMTILLVSLLCAFITVVLGHVFSPSDAQLAQLNDGVPVSGSSGLFDLVQNMSPEQQQILLQASAASTFSGLIGNAILAGGVILIIQLVSAGQRVSALRAIGASAPILPKLFILIFLTTLLVQIGIMLVVVPGIIMAILLALAPVMLVQDKMGIFASMRSSMRLTWANMRLVAPAVLSWLLAKTLLLLFASSFAALTPEIGAVLANTLSNLISAILLIYLFRLYMLIRQ
What are the official names of this protein?
UPF0259 membrane protein YciC.
What is the protein family that this protein belongs to?
Belongs to the UPF0259 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRH_CLOPS
Sequence: MGTCKYKRVMLKLSGEALAGENGFGIDFNIAMNIAKAVKELVDMGIEVGAVVGGGNIWRGRSGEGMDRTTADYMGMLATSINALALQDSLESLGVDTRVQTAIEMKEIAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFSTDTAAALRAAEIEADVILLAKKVDGVYDKDPHKYDDAKKYDELSYIEVLEQGLQVMDSTATSLCMDNNIPILVFALDNPENIKKVVLGENIGTIVSKK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCDB_MYCVP
Sequence: MLLSDRDIRAEITAGRLGVDPFDDSLVQPSSVDVRLDNLFRVFNNTRYTHIDPAQRQDDLTSLVEPKEGEPFVLHPGEFVLGATLERCTLPDDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCLLRLTSPAEHPYGSSSVGSKYQGQRGPTPSRSYQNFVKND
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: YGFZ_ECOK1
Sequence: MAFTPFPPRQPTASARLPLTLMTLDDWALATITGADSEKYMQGQVTADVSQMTEDQHLLAAHCDAKGKMWSNLRLFRDGDGFAWIERRSVREPQLTELKKYAVFSKVTIAPDDERVLLGVAGFQARAALANLFSELPSREKQVVKEGATTLLWFEHPAERFLIVTDEATANMLTDKLRGEAELNNSQQWLALNIEAGFPVIDAANSGQFIPQATNLQALGGISFKKGCYTGQEMVARAKFRGANKRALWLLKGSASRLPEAGEDLELKMGENWRRTGTVLAAVKLEDGQVVVQVVMNNDMEPDSIFRVRDDANTLRIEPLPYSLEE
What is the function of this protein?
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs.  It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
What are the official names of this protein?
tRNA-modifying protein YgfZ.
What is the protein family that this protein belongs to?
Belongs to the tRNA-modifying YgfZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_LISMF
Sequence: MVMTDPIADFLTRIRNANMVKHDKLELPASKIKKEIAEILKREGFIRDVEYIEDDNAGTIRVFLKYGATGERVITGLKRISKPGLRVYAKSTEVPKVLNGLGIAIVSTSQGVLTDKEARAKQVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RFU1_YEAS1
Sequence: MKSSKQLVQDAKDYRFNPAIPLRIYLKTCIGILEKAQCAFQANDLSLSFIYYFRYVDLLTNKLSRHPELLRMDASSSSSSSYIHKREYLQLIKLEVPAVCKIIESLRTQIDSQYSKLQTSLANNIAKPNINANTTPVQVEQQPLPKKSFDEYSFNQSISFFQKISNAQLNTGASSQSQATARDEAYRLNYPELPRLTFST
What is the function of this protein?
Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.
What are the official names of this protein?
Regulator of free ubiquitin chains 1.
What is the protein family that this protein belongs to?
Belongs to the RFU1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: PDIA6_MOUSE
Sequence: MARLVLGLVSCTFFLAVSGLYSSSDDVIELTPSNFNREVIQSDGLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGSFPTITPREPWDGKDGELPVEDDIDLSDVELDDLEKDEL
What is the function of this protein?
May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:24508390).  Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity).  May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity).  Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity).
What are the official names of this protein?
Protein disulfide-isomerase A6, Thioredoxin domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Cell membrane. Melanosome.
Protein: PAN3_ASPFU
Sequence: MASAGKPALDDSRRGTGSPKIKGRENAKDTLCRNITIYGRCRYEDKGCAFNHDPHKVNSSNQSDSKKRFNVDSPSFTPSLLSSNGSSPTSTPATTKKMTTISPKAANAAPFQPRSVVSRSNASTPGLRQDTVTPDWTVAEVQEFVPQGFDNSHLAALQGNGNGPITSTSPFDPFVTTPTPLSAGGAVGPVQPNPYSHDAAAALGGAAFFPGAAGFQQPVQYHLYAPIGPHNQNTLGYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQIDYFHSLVPLDLNHQKNATIFGFPSWVYKAQSSKDGNYYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTVHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLGAGQQRFQGRHNVQHIPEQILWGYMTQIANALKAIHSNGLAARVIDASKILLTGKNRIRLNACAIMDVVQFDSQRTVADLQRQDLVNFGQLIVTLGANSPTVMHNPTKAMEHFTRAYSPQLKNSVFWLLNGMQKDQDRNIDVFITGISSQLMSTFDSALHLDDQLTSDLSRELENGRLVRLMAKLNFVNERPEYEHDRQWSENGERYFLKIFRDYVFHQVDAQGDPVVDLGHVITCLNKLDAGTEEKITLISRDEQSCFIVSYKELKKALESSFQALMKPARRMH
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.  pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit PAN3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCM31_MAIZE
Sequence: MEINEEAMAAHKRAFLDFLDQDVGKGVYMQAVRDMVQNKRHRLIIGMDDLRNHNLDLARRVIRTPGEYMQPASDAVSEVARNLDPKFLKEGERVMVGFSGPFGFHRVTPRDLMSSFIGTMVCVEGIVTKCSLVRPKVVKSVHFCPVTGDFLSREYRDITSFVGLPTGSVYPTRDDNGNLLVTEYGMCEYKDHQTLSMQEVPENSAPGQLPRTVDVIVEDDLVDCCKPGDRVSIVGVYKALPGKSKGSVSGVFRTVLIANNVSLLNKEANAPVYTREDLKRMKEISRRNDTFDLLGNSLAPSIYGHLWIKKAVVLLMLGGVEKNLKNGTHLRGDINMMMVGDPSVAKSQLLRAVMNIAPLAISTTGRGSSGVGLTAAVTSDQETGERRLEAGAMVLADRGVVCIDEFDKMNDQDRVAIHEVMEQQTVTIAKAGIHASLNARCSVIAAANPIYGTYDRSLTPTKNIGLPDSLLSRFDLLFIVLDQMDPEIDRQISEHVARMHRYCTDDGGARSLDKEGYAEEDDGDANAAIFVKYDRMLHGQDRRRGKKSKQDRLTVKFLKKYIHYAKNLIQPRLTDEASDHIATSYAELRDGSANAKSGGGTLPITARTLESIIRLSTAHAKMKLRHEVLKSDVEAALQVLNFAIYHKELTEMEEREQKEMEMKQQAEHDAGATGGTVDGHGSSGNDPMDVDVGSNDQNVSAERIEAFEALLGQHVLANHIDQMSIDEIEQMVNRESTAPYTRSQVEFILERMQDANRVMIRDGVVRII
What is the function of this protein?
Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle.  Required for DNA replication and cell proliferation (By similarity).  May act as a component of the MCM complex which is the putative replicative helicase of the replication licensing system in eukaryotic cells.
What are the official names of this protein?
DNA replication licensing factor MCM3 homolog 1, Replication origin activator 1, ROA-1.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus.