PharMolix/UniProtQA huggingface dataset:
Protein: ASSY_VIBCM
Sequence: MSKVQVKKVVVAYSGGLDTSVIIPWLKENYDCEVVAFVADVGQGDEELKGVEAKALSSGASECYIVDLKEEFVKEYIYPTLKTGAYYEGKYLLGTSMARPVIAKAQVEIARKVGADALAHGCTGKGNDQVRFEGAFAALAPDLHVIAPWREWDLRSREACLDYLAERNIPCAASLTKIYSRDANAWHVSTEGGVLESTWNAPNEDCWVWTVDPEQAPNEAEYVTLQVAHGEVVAVDGEAMTPYNALLYLNQKGAKHGVGRIDIVENRLVGMKSRGCYETPGGTIIMEALRAVEQLVLDKTSFEFREELGIKASHLVYDGRWFTPLRQAVFAAADELAKDVNGEVVIKLYKGQAVATQKRSANSLYSEDFATFGADEVYDHSHAGGFIRLYSLSSRIRALSQNKQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_BORT9
Sequence: MGQKVHPYSLRIKINRDWKSKWYFDKKLYSEILHEDFLIRRETMKFLKGIRFDISDIEIIRNNLQRVTVIISTPRPGSVIGVKGANLEKIGQLLTRKISKKINIKIKEIKKPEFDAQIVANGIAKQLENRASYRKLLKSSLLSSISKGVQGVKIKVSGRLGGAEIARSFEVKEGRIPLHTLRANIDYGFAEAQTTYGVIGVKVWLFKGEVLGKQTNSDAGQVINKKTSREKSEYFDKNRVDDKSKKVVNDDKFSRKKLEFGSKSNSSFKKKNGSDV
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: NU6M_SARGL
Sequence: MNSLFMIFSLGIVGASLMVISTPNPVYSVFWLVIAFVNAAVMFISLGLDYIGLIFIIVYVGAIAILFLFVIMLIQQPNKIDSQDHSHFLPIGLSVIFLFYSLLTNSPKYISNPVIGSRTNIGAIGSHLYTTYYELVLIASLVLLVAMIGAILLAKQPNSPFLYNSHGESLRSRQDLFLQISREHL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: NUOB1_BURM7
Sequence: MSIEGVLKEGFVTTTADKLINWTRTGSLWPMTFGLACCAVEMMHAGAARYDLDRFGVVFRPSPRQSDVMIVAGTLCNKMAPALRRVYDQMAEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALVYGVIQLQAKIRRTSTIARQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 1, NADH dehydrogenase I subunit B 1, NDH-1 subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SDIS_NOCSI
Sequence: MSAEVKAAVARYLDAVAGGSPAAIAALYAPDATLEDPVGADLVRGRAAIEEFYGALAGAKVSTELLAVRAVAGHAAFSFRVTTDAGDQQYVVEPIDVMTFDADGQITSMRAFWAPGDMVVTPA
What are the official names of this protein?
Steroid Delta-isomerase, Delta(5)-3-ketosteroid isomerase.
Protein: YACG_VIBVY
Sequence: MTKITIVKCPQCGTDVEWGEQSPHRPFCSKKCQMIDFGEWADEENAIPGAPDMSDSDGWSEEQY
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: ACEK_RHOP2
Sequence: MTATRHPFASDIDAATRIAEPDFDLLDALVRTDDPDDQAHTLARVVLAAFDNYYAVSRRIPALAQAAFEARDWAATVRLSKIRLGLYTACIDQLVPLLKAGLPELANDEQLWARAEAELLAAIAERYEADFAFAFWQSLRRKLVSDEWRPVSYDTGPAARPKATSAAILKTIATTLPIRPAVIRDILDGAGLRGPWRDRDGDAALAAAAIEAALEPLGPRAGETAKIEIAESGFFRNRGACLVGRVRLRDRGDMPMRNLPLLIALLNEDDGLVVDAVLCDADELQYAFSSTLANYHATNPHYHELARLLHELMPKRPLGTQYSCIGFHHLGKVAVMTEILAEHRRSKEKLDTAPGFKGTVAIAFTMPSSAYVLKIIRDHPTDDYKFDYFDGLDAVLRKYNLVHEIDRAGSMLDNIIYSNVKLERTMFAPDLLDELLESGIDTVTLERGALVFRHLIVQIKLTPLPLYLTTASAADARAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDYDAVEPLTDVRVRGDDAPPGPEFEDGVVFRPADMLGGLRIDDPALRRAFRDAHPELMQPEYWQGMQRALRAGKVPRVMNYPAARRLRR
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLND_SALTI
Sequence: MNTLPEQHANTALPTLPDQPQNPGVWPRAELTVAGIKARIDIFQHWLGEAFDSGICAEQLIEARTEFIDQLLQRLWIEAGFGQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDEQAQKVGELLTLLWDVKLDVGHSVRTLEECLLEGLSDLTVATNLIETRLLIGDVALFLALQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTPAECAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNDPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPVDDEFQLRGTLIDLRDDTLFIREPQAILRMFYMMVRNSAITGIYSTTLRHLRHARRHLSQPLCYIPEARTLFLSMLRHPGAVSRGLLPMHRHSVLWAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFAKEETRQRHPLCVDLWPRLPHPELILIAALFHDIAKGRGGDHSVLGAQDVLTFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTETRLRFLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEAALHKIWTRCRANYFVRHSPNQLAWHARHLLQHDLSQPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLAADRHDVIRTGLEQTITQHSWQPPQPRRQPAKLRHFTVETEVNFLPTHTDRKSFMELIALDQPGLLARVGQIFADLGISLHGARITTIGERVEDLFIIATADRRALNNVLQLEVQQRLTAALNPNDKG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: ACAC_CATRO
Sequence: RISSSVIAHKTQLDSGKREVYSSHMQLGGPK
What are the official names of this protein?
Acetyl-CoA carboxylase, ACC.
Protein: RL29_PECCP
Sequence: MKANELREKSVEELNTELLGLLREQFNLRMQAASGQLQQTHLVKQVRHNIARVKTLLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: F181B_BOVIN
Sequence: MAVQAALLSTHPFVPFGFGGSPDGLGGAFGALEKGCCFEDEETGTPAGALLAGAESGDAREATRDLLSFIDSASSNIKLALDKPGKSKRKVNHRKYLQKQIKRCSGLMGAAPPGPSSPGAADTPAKRPLAGAQTVPVPVPAHGKAAPRREASQAAAAASLQSRSLAALFDSLRHVPGGADPAGVAEAVPAAGLVRGDAAGSAGGPAVPGARKVPLRARNLPPSFFTEPSRAGGCVCGPSGPGVSLGDLEKGSEAAEFFELLGPDYGAGTEAGALLAAEPLDVFPAGAAVLRGPPELEPGLFDPQPAMVGSLLYPEPWSAPGGPATKKPPLPAPGGGLTLNEPLRSVYPAAADSPGGDDGPGLLASFTPFFSDCALPPAPPPQQVSYDYSAGYSRTAFAGLWRPDGAWEGAPGEEGAPRD
What are the official names of this protein?
Protein FAM181B.
What is the protein family that this protein belongs to?
Belongs to the FAM181 family.
Protein: ODPB_RAT
Sequence: MAAVAGLVRGPLRQASGLLKRRFHRSAPAAVQLTVREAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDDNPVVMLENELMYGVAFELPTEAQSKDFLIPIGKAKIERQGTHITVVAHSRPVGHCLEAAAVLSKEGIECEVINLRTIRPMDIEAIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, PDHE1-B.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RECR_TROW8
Sequence: MYVRIVQDLIRELGKLPGIGPKSAQRIAFFILQNPSFDIDRLSETLQSVRKQVQFCKVCGNFSEEDECVICSDPRRDRGVICVVEEPKDVVAIEKTREFSGLYHVLGGAISPIDGVGPDDLNIRQLLQRLADGTITEVVLATDPNMEGEATASYIARVISAMRIRVSKLASGLPVGSDLEYADEITLGRALEGRQYIN
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RL18_BURP1
Sequence: MDKTQSRLRRARQTRIKIAELQVARLAVHRTNTHIYAQVFSPCGTKVLASASTLEAEVRAQLADKSGKGGNVAAATLIGKRIAEKAKAAGIESVAFDRSGFRYHGRVKALAEAAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: K1C27_CAPHI
Sequence: MSVRFSSASRRLGSCGGAGSVRLSSGGAGFGVGSTGSVPGFGSGFTCAFGGSSSAGSYSGGLGGGSASCTAFTGNEHGLLSGNEKVTMQNLNDRLASYLDNVRALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFTVIDDLRNQIISATTSNANIVLQNDNARLTADDFRLKFENEQALHQSVDADVSSLRRVLDELTLCRTDLEIQLETLSEELAYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISDDAGATTSARNELTEMKRTLQTLEIELQSLLATKHSLECSLTETEGNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCRLIDGEDGSCTKSKGYGGPGNQIKDPSKATVVKTIVEEIDPRGKVPSSRVHTVEEKSTKVNNMKSEQRVPS
What is the function of this protein?
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).
What are the official names of this protein?
Keratin, type I cytoskeletal 27, Cytokeratin-27, CK-27, Keratin-27, K27, Type I inner root sheath-specific keratin-K25irs3, Type I keratin intermediate filament C29.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HETS_PODAS
Sequence: MSEPFGIVAGALNVAGLFNNCVDCFEYVQLGRPFGRDYERCQLRLDIAKARLSRWGEAVKINDDPRFHSDAPTDKSVQLAKSIVEEILLLFESAQKTSKRYELVADQQDLVVFEDKDMKPIGRALHRRLNDLVSRRQKQTSLAKKTAWALYDGKSLEKIVDQVARFVDELEKAFPIEAVCHKLAEIEIEEVEDEASLTILKDAAGGIDAAMSDAAAQKIDAIVGRNSAKDIRTEERARVQLGNVVTAAALHGGIRISDQTTNSVETVVGKGESRVLIGNEYGGKGFWDN
What is the function of this protein?
Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition).  Forms a prion for the non-Mendelian trait [het-s].  Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons.  It is unknown if the native, soluble protein has a cellular function.
What are the official names of this protein?
Heterokaryon incompatibility protein s, Small s protein, Vegetative incompatibility protein s.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPOLA_BPPM6
Sequence: MSYLQPPLFTTVSSDWVAPDLSTLPSWEGAKRVAIDCETRDPDLRKLGPGAGRRPNSYITGISFAIEDGPGGYLPIRHEGGGNLPLEGVLAYLRAQAKVFTGDLVGANLPYDLDFLAGDGIEFERVRYFRDIQIADPLICELHDSYSMQAIAERWGFHGKDEALLRAAAVDYGIDPKKDMWMLPAKFVGKYAEEDTRLPLNILRRQEREIDEQDLWGVYNLESKLLPILTGLRRRGVRIDCDRLDMIERWALEKETEALAQVRSITGHRIAVGDVWKPEVIAPALEHIGIKLNKTSQGKPNIDKELLGSIDHPVADLLERARKVNKLRTTFASSVRDHMVNGRLHGTFNQLRRQKDDESDGTAGAAYGRLSSEHPNLQQQPARDEFAMMWRAIYLPEEGQHWASNDYSQQEPRMAVHYACLAKDLIGHQAWLSAIEARDKYRNDPNTDNHQMMADMAGIKRKDAKEIYLGLSYGMGGAKMCRKLGLPTMMAVRGPRFQLFDVNSPEGQRLVAEGARRFEAAGPEGQALLDTFDHKVPFIKKLAKACEARAKAVGYITTLSGRRCRFPKDKDGNYDWTHKGLNRLIQGSSADQTKMAMVACAEAGLDIIIQVHDEIAFSVHDMKEAAEAAHIMRTCTPLELPSKVDVEIGQSWGHSMGWDGNPPS
What is the function of this protein?
DNA polymerase that replicates the viral genomic DNA (Probable).  Also incorporates 5-hydroxymethyl-2'-deoxyuridine (5-hmdU) instead of dTMP into DNA during replication, as an early step in the pathway of thymidine hypermodifications of the viral genome (PubMed:34522950).  As a final result of the pathway of hypermodification, 5-aminoethyl-2'-deoxyuridine (5-NedU) substitutes for about 30% of thymidines in the viral DNA (PubMed:34522950, PubMed:29555775).  These modifications probably prevent degradation of viral genome by the host restriction-modification antiviral defense system (PubMed:34522950).
What are the official names of this protein?
DNA-directed DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-A family. DpoZ subfamily.
Protein: PHB2_RAT
Sequence: MAQNLKDLAGRLPSGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK
What is the function of this protein?
In the plasma membrane, is involved in IGFBP6-induced cell migration (By similarity).  Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates.  Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
What are the official names of this protein?
Prohibitin-2, B-cell receptor-associated protein BAP37, BAP-37.
What is the protein family that this protein belongs to?
Belongs to the prohibitin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Cytoplasm. Nucleus. Cell membrane.
Protein: RS10_UREPA
Sequence: MNQELRIRLESYDHRLLDDTVKTIVNISNSTGSKLRGPIPLPTKKEIFTILRSPHVNKSSREQFERRTHKRLIILENPQPKTMEALKRLSVPFGVEVTFKI
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RIMM_NOCFA
Sequence: MELVVGRVAKSHGVRGELVVEVRTDDPDARFAEGTVLRGRLPRSTEVREFTVESAREHSGRLLVSLAGVDDRSAADALRGTLFVVDSAELPPSDDPDEFYDHELEGLSVRDTAGAVLGTVTEVLHSAAGELLSMRAAEDGREILIPFVTAIVPTVSVAEGYVVIDPPEGLLDPE
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STI1_YEAST
Sequence: MSLTADEYKQQGNAAFTAKDYDKAIELFTKAIEVSETPNHVLYSNRSACYTSLKKFSDALNDANECVKINPSWSKGYNRLGAAHLGLGDLDEAESNYKKALELDASNKAAKEGLDQVHRTQQARQAQPDLGLTQLFADPNLIENLKKNPKTSEMMKDPQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLNMDDINQSNSMPKEPETSKSTEQKKDAEPQSDSTTSKENSSKAPQKEESKESEPMEVDEDDSKIEADKEKAEGNKFYKARQFDEAIEHYNKAWELHKDITYLNNRAAAEYEKGEYETAISTLNDAVEQGREMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLTEHRTADILTKLRNAEKELKKAEAEAYVNPEKAEEARLEGKEYFTKSDWPNAVKAYTEMIKRAPEDARGYSNRAAALAKLMSFPEAIADCNKAIEKDPNFVRAYIRKATAQIAVKEYASALETLDAARTKDAEVNNGSSAREIDQLYYKASQQRFQPGTSNETPEETYQRAMKDPEVAAIMQDPVMQSILQQAQQNPAALQEHMKNPEVFKKIQTLIAAGIIRTGR
What is the function of this protein?
May play a role in mediating the heat shock response of some HSP70 genes.  It is required for optimal growth of yeast cells at both low and high temperature.
What are the official names of this protein?
Heat shock protein STI1.
Protein: YDCA_BACSU
Sequence: MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRDTVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYAGSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLAFAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY
What are the official names of this protein?
Putative rhomboid protease YdcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEPH_ASPFN
Sequence: MFTLTEYFIAACVWLVLYKVGNLLWNRHHYFKQQKARGCGEIKHYRHRDPILGLDFVYTLSKAFKEHRWLPWQQELFAAQGVKTFQANFLGSRAIYTSESENMKAMSTTYWREFGLEPLRRGSGAADPVAGPGVSTVDGPMWDFSRNIIKPYFTRDGYSNLARLEVFVNRLLDLVPTDGSTFDMQPLLQRWFLDTSSEFLFGKTVDSLTHPENVKVAKAMVDTMRGIRVRLTMSKLMFLHRDPVWMENVKIVRDFVDERIDASLTQLQDVKSGKGTSCTENQPDGRTDLLWDMVQQLQDKEALRGQIMAVFIPSNDTTSILISNAIYALARHPHVYQTLREEVLALGDQEITFEKLRGLRYLRYVINETHRLYPNGIQMVRIALEDTTLPVGGGPDQSQPIFIQKGDIVHANRYLMHRDPDNWGPDAEVFRPERWGDVRPLWKFVPFGGGPRICPAHVLVDTEASYVLLRFVQRFRTLEPRDERPYKAIMRIGPSNLHGVNVAVKTA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster 23 that mediates the biosynthesis of a family of 2-pyridones known as leporins (PubMed:20447271, PubMed:26051490).  The hybrid PKS-NRPS synthetase lepA and the enoyl reductase lepG are responsible for fusion of phenylalanine with a hexaketide and subsequent release of the stable tetramic acid precursor, pre-leporin C (PubMed:26051490).  Because lepA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase lepG (PubMed:26051490).  It is possible that the dehydrogenase lepF also participates in production of pre-leporin C (PubMed:26051490).  Cytochrome P450 monooxygenase lepH is then required for the ring expansion step to yield leporin C (PubMed:26051490).  Leporin C is then presumably further oxidized by the N-hydroxylase lepD to form leporin B (PubMed:26051490).  LepI may possess a function in biosynthesis upstream of lepA (PubMed:26051490).  Leporin B is further oxidized in the presence of ferric ion to give the leporin B trimer-iron chelate, but whether or not this reaction is catalyzed by an enzyme in the pathway or by ferric ion is not determined yet (PubMed:26051490).
What are the official names of this protein?
Cytochrome P450 monooxygenase lepH, Leporins biosynthesis protein H.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: EX7S_LACJO
Sequence: MAIKKNNFEEQLNELQEIVNKLESGNVPLEDALSEFQAGVKLSRELEKKLNDAEQTVAKLVDKDGNEKALDPQNASAPEEE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_SALPB
Sequence: MAKRDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDAQKRAAYDQYGHAAFEQGGMGGGFGGGFNGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMDLTLEEAVRGVTKEIRIPTLEECDVCHGSGAKAGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCHKCHGHGRVEKSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVMLKVPSETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLSEKQKQLLKDLQESFGGPTGEKNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_XANAC
Sequence: MSGLLCYCRPGFEPELAAELSVRAAFVGIAGYARTQRNDGYVLFVCDEAAQLAAKLQWRELIFARQKLVVIAELKGIDPKDRITPILAALDGQQRFGDLWVEHPDSDAGKPLAGLARSFGNALRPALRKAGLLTDKPQPRQPRLHVCFLDGDHALLAVADSADSAPWPLGIPRLKLLPEAPSRSALKLDEALLTLLTPEERDALVKPGMRAADLGAAPGGWTWVLTRQHVHVTSVDNGPLREHVLETGLVEHLRADGFHWKPAQPLDWMVCDMVEQPRRVAERMATWVREGWCRNTIFNLKLPMKKRWDETRLCLDLFEQQAERSLSVRAKQLYHDREEITVLAMRD
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR219_MIMIV
Sequence: MNKTTSQEILKTNNCLEWLFEKIFKQLVPNKQELYDLPFSEIYSRTFCNSQIHQLIAESLKSTVIEIETYLTDKKFIEKFLFVSVRREYKFRIKKLHVQIMLKEYDKIEFLINSGYKVDFDSLKLACLNGSLDILNLLLKFYQKKLSSELLMYCSEFSHYDIYQLLTTKYNLYPNLSVFYRAVLSDSIEIVEDVSSNISANQQVMENAFKTNHTDIINLLLIRAKKDGTHIDRNLVVYPIMNCNFELLTILSNMNLIDWHVELYYSALLSGSMEMITYLEDKIDKINPDFHKKKILDSSHQSSGKNSLLLEDIIYEIDGKKYFSHTMNYAIQSGSVNVVDYIWSRGYGITVSNFITAIKQGSVEILERLCKWYHLKLPIYLIHYFSTKSYVTNKIAKAKVLIENKLLMINEPVQECIELYKKEETHIKLIEQPTQIVSDSKYDPDYLMQYSMFFIPMKGFKLNHRLITQIRINLQLNYMDSLVELYTRDRNYADKMILLNNLFLFGTIDQIKILYPLLKTKYCPDKPILMEIICKCEITKLCYLKNNRLLDNDVVQSLIPLVIMLENPLINALFSKLTTVNLIDKYIVLSNNVTLIRKWLNESPVIDKNQIKSLFLLDDTKITDSILSKYSVTICKHKEEFLDWCQEEDLLDTRQKIEKKYLK
What are the official names of this protein?
Putative ankyrin repeat protein R219.