PharMolix/UniProtQA huggingface dataset:
Protein: RND_XANOR
Sequence: MPHWITHPSELTDRLQAARPARIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMNAALKEWLTATDIVKVMHSASEDLVTFKCACGVLPRPLFDTQIAAALAGVGGGMGYQKLVQEVTGTLLTKGETRSDWMRRPLSPSQLEYAADDVRYLFAIHDELTRRLTEQNRLGWLAEDAERLLATVEHDDGERWPHVSLRTAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILDNEVASQLARFPPADLDALLQQFDKFPKAPRKLANAVWDALNTPLPDEEHAPLAQAATDGNKAVLKRLQDTVAQRSHELGLPDGLLASRRHLETLIEQRSWPAALGQWRRAVLEAQVMPLLEASEA
What is the function of this protein?
Exonuclease involved in the 3' processing of various precursor tRNAs.  Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.
What are the official names of this protein?
Ribonuclease D, RNase D.
What is the protein family that this protein belongs to?
Belongs to the RNase D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPA_METPE
Sequence: MFEGVLPAIVTPFQNDHAKSLDLLGLQSNLAFLVSKGVHGVVPCGSTGESATLSFEEHVKVIEATIEAVAGKVPVLAGAGSNNTDEAIRFTRSAKDLGADGVLIISPYYNRPNRSGLIKHFSAIADLDIPVVLYNVPSRTGQNLSPDLVAELSRHPNIVGIKEASGNISQVSQIIEETMDQDFTVISGDDGMTLPVMALGGGGVISVAANVEPERMVGMYRAYTEGDWDDAISLHYELAPLFRALFIDSNPIPVKKAINLRGLASGPLRLPLDELDAEKTAALTEVLSTYD
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSM6_AJECN
Sequence: MENGSASEGKDPSAFLSEITGAPVTVKLNSGVVYKGELQSVDGYMNIALEKTEEYVDGKLRRSYGDAFVRGNNVLYISAD
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates.  Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6. U5 tri-snRNP, and free U6 snRNP).  It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm6.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TIG_SHIFL
Sequence: MQVSVETTQGLGRRVTITIAADSIETAVKSELVNVAKKVRIDGFRKGKVPMNIVAQRYGASVRQDVLGDLMSRNFIDAIIKEKINPAGAPTYVPGEYKLGEDFTYSVEFEVYPEVELQGLEAIEVEKPIVEVTDADVDGMLDTLRKQQATWKEKDGAVEAEDRVTIDFTGSVDGEEFEGGKASDFVLAMGQGRMIPGFEDGIKGHKAGEEFTIDVTFPEEYHAENLKGKAAKFAINLKKVEERELPELTAEFIKRFGVEDGSVEGLRAEVRKNMERELKSAIRNRVKSQAIEGLVKANDIDVPAALIDSEIDVLRRQAAQRFGGNEKQALELPRELFEEQAKRRVVVGLLLGEVIRTNELKADEERVKGLIEEMASAYEDPKEVIEFYSKNKELMDNMRNVALEEQAVEAVLAKAKVTEKETTFNELMNQQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
Protein: DAPA_LISMH
Sequence: MDLGKVITAMVTPIHPEKDKVCKKRIHHLVNHLIENGSDGLVIAGTTGESPTLSHDEKIKLFRQVIETNDGRAKLIAGTGSNNTAETIAFTKEVAELGGIDAVLIVAPYYNKPNQDGLYAHFAAVAEASDLPVVIYNIPGRSVVNIEPETIIRLAALPNIVGVKESSGNLDNISKIIAETSDDFQVYSGDDSLTLPILAVGGNGVISVASHVVGNEMQEMIQAFERGEVQKAAQIHRELLPLMNGLFSVPNPAPTKYLLNQQGISVGPVRLPLVDLNAEQGTKLQAILEGLSK
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSB_RHOP2
Sequence: MTAPRTLVLIPARMAATRLPGKPLLDIGGVPMVVHVLRRALAANIGRVAVATDTPAIADAVRAHGGEVVMTRADHPSGSDRIHEALQTLDPQRTIETVINLQGDFPTIRPEQIGAVLAPLDDPAVDIATLAAEIHTEEESTNPNVVKVVGSHIGTTRLRALYFTRATAPWGDGPRYHHIGLYAYRRAALERFVALPPSPLEQREKLEQLRALEAGMRIDVGIVDSVPRGVDTPADLETARRVLAG
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_YERPA
Sequence: MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDIYLLADENLNTLIDYRFVKSFRAERGQNGQSRDCTGKRGKDITIKVPVGTRVLDQGTGEIVGDMVRHGQRLMVAKGGFHGLGNSRFKSSVNRAPRQKTMGTEGETRELMLELLLLADVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVRMDYEQSFVIADIPGLIEGASDGAGLGIRFLKHLERCRVLLHLVDLAPIDESDPAENAKVIVNELQQYSENLAEKPRWLVFNKIDLIDPEEAEKRAKAIVETLGWEGKYYMISAANRDNVNALCWDVMSFLNSQPKAMAIAESVPEKVEFMWDDYHREQLAEVEAEAEDDWDDDWDEEDDDGVEIIYER
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_PSYCK
Sequence: MNINSTLIGQAIAFAIFVMFCMKFVWPPLIGAINDRQRKIAEGLNAAEKAKADLATAERDVQQELDLAKTKAAALIEQANKSANQLVEDAKSQAQVEGERIRQQAQASIDQEINQARESLRAQVAELAVLGAEKILQDKVDVQKHASMLDQLAAKL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: SYY_SYNP6
Sequence: MTDSWTWLQRGTHEIFPDQPESADPDVSLLARLQQGDRPLRIKLGIDPTGSDIHLGHSIIFRKLRQFQDAGHTAVLIIGDFTARIGDPTGKSEVRRQLTAEDVQRNAETYLDQLRPILDFETPGRLEIRYNSEWLAGLDLAKILELLGTMTVGQMLAKEGFSERYDKGTPVYLHEFLYPLMQGYDSVAVQSDVELGGTDQKFNIAVGRDLQRHFGLQPQFGLLLPILIGLDGSQKMSKSLGNYVGLNEDALSMYSKLEKVPDALVADYFELLTSQDLAALPENPRDRQKLLALDVVSQYHGAEAAAAAQKAAQELVQGSAVQAEAVPEFPLSQVNFPAKAFYLVSAVGLGLTSSEARRQIQGGAVRLDGQKLDDPNHIFEAPTALKGRVIQVGKKKFVRLVL
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPGF6_HUMAN
Sequence: MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases.  Does not interact with cAMP.
What are the official names of this protein?
Rap guanine nucleotide exchange factor 6, PDZ domain-containing guanine nucleotide exchange factor 2, PDZ-GEF2, RA-GEF-2.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Upon binding to M-Ras, it translocates to the plasma membrane.
Protein: KMO_CAEEL
Sequence: MPSVAIAGAGLVGALNACFFAQKGWDVSVYEFRKDIRTMKHVQGRSINLALSQRGKSALEAVGLKEYIVNQGVPLYARLIHNKDGKTYSRQPYGKPGEHIVSINRRHLNEVMITQAEKSPNVKFFFEHKVKNVDYDKKQLVVQCTSQPSKIPTFGNKSPPQEHAEFHVEADLILACDGAYSAVRRSLMTIPRFDFSQEYIEHGYVELNIMANNNEFAFEENVFHLWPRGHFTLIALANRDKTFTVTIFAPFSEFEKHMSTSEDVLSFFEENFPDAFLLLGKEHIADTFNRVKPQPLVSIKCSPHSFFDNLVLMGDAAHAMVPFYGQGMNCGFEDCLVFSETLEEYGNDIAKAVKVYSDGRVNDAHSINDLAMYNYEELKDLVNKSSYKLRKKFDTIMNSIFPKSWIPLYSMVTFSRIPYSEVIERRKRQDKILSRIMTTTSTLALIGAAAGIYVNRGKLGL
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Multi-pass membrane protein.
Protein: RPE_HUMAN
Sequence: MASGCKIGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITFGHPVVESLRKQLGQDPFFDMHMMVSKPEQWVKPMAVAGANQYTFHLEATENPGALIKDIRENGMKVGLAIKPGTSVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPSLDIEVDGGVGPDTVHKCAEAGANMIVSGSAIMRSEDPRSVINLLRNVCSEAAQKRSLDR
What is the function of this protein?
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
What are the official names of this protein?
Ribulose-phosphate 3-epimerase, Ribulose-5-phosphate-3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the ribulose-phosphate 3-epimerase family.
Protein: GLK_YERPB
Sequence: MTTYALVGDVGGTNARLALCAVATGEILQAKTYSGLEYESLEDVIKQYLSEHQAKVTDACIAIACPITGDWVAMTNHTWAFSIAAMQQNLGLDHLEVINDFTAVSMAIPVLPAQDVLQFGGTQPQPGKPVAVYGAGTGLGVAHLVNVDRRWISLAGEGGHVDFAPNSEEEDQILAVLRQELGHVSAERVLSGPGLVNLYRAIVISDARLPEKLAPKDITARALADSCTDCRRALSLFCVIMGRFGGNLALNLSTFGGVYIAGGIVPRFMEFFKASGFRAAFEDKGRFKDFLQDIPVYMITHPQPGLLGAGAYLRQKLGYELSS
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YD109_YEAST
Sequence: MEAGRSADEVLYHNQSSVKLGELERYVITYELYQGDSIPADITLDSLWVKIKNTTKLSYKPAYLLGPFILYCDVRAKDYESSYKIICSADKPVFQSNLQAQQKFIAELSLHHIKPRYVWIVDIVSQILFNKETKVTFEIVVGNSKASLKRKIRCNDSLPDKACNILHTGLSVHRLTTADIWKVPRPIDMSQKSHLVILTHGFQSNVSADMEYLMEEIYKAQMNNPNERLVIKGYMKNACETEKGIKFLGVGLANYIIDELYDDSVGKISFIGHSLGGLTQTFAICYIKTKYPYFFKKVEPINFISLASPLLGIATSTPNYVKMSLSMGIIGTTGQELGLKDGNYGDKPLLYLLSEESLISVLARFKRRTLYANAVNDGIVPLYSSSLLFLDYSQLLQKLGGQTTAPCDPLFQPEVSPIGELPNHSDVANDDDGINASSWNTFWKSKENNCDKKSKRLMNASVIKSMKSVLLSPCPDAKFFSDPDARVATIIHDKIYTEKNLPPPSPTLYEGTAAKEGETRKTRKEMEEIIARRWHKGMHWRKVVVLLKPDAHNNIIVRRRFSNAYGWPVVDHLVTAHFQRDDPIASPMQDKQFAEEDINMATGGVEPNKFYSWLTKIEDPSVYHGGIVSTASQLASSWISKHSSVTD
What is the function of this protein?
Involved in lipid metabolism.
What are the official names of this protein?
Putative lipase YDL109C.
What is the protein family that this protein belongs to?
Belongs to the putative lipase ROG1 family.
Protein: LEUE_SALTY
Sequence: MFAEYGVLNYWTYLVGAIFIVLVPGPNTLFVLKNSVGRGVKGGYLAACGVFIGDAILMFLAYAGVATLIKTTPVLFNIVRYLGAFYLLYLGAKILYATLTSKGRAATETVVPFGAIFKRALILSLTNPKAILFYVSFFVQFIDVTAPHTGVSFFILATTLEIVSFCYLSFLILSGAFVTHYIGTKKKLAKVGNSLIGLLFVGFAARLATLQS
What is the function of this protein?
Exporter of leucine.
What are the official names of this protein?
Leucine efflux protein.
What is the protein family that this protein belongs to?
Belongs to the Rht family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ZNUC_ECOUT
Sequence: MTSLVSLENVSVSFGQRRVLSDVSLELKPGKILTLLGPNGAGKSTLVRVVLGLVTPDEGVIKRNGKLRIGYVPQKLYLDTTLPLTVNRFLRLRPGTHKEDILPALKRVQAGHLINAPMQKLSGGETQRVLLARALLNRPQLLVLDEPTQGVDVNGQVALYDLIDQLRRELDCGVLMVSHDLHLVMAKTDEVLCLNHHICCSGTPEVVSLHPEFISMFGPRGAEQLGIYRHHHNHRHDLQGRIVLRRGNDRS
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CL19A_HUMAN
Sequence: MQRWTLWAAAFLTLHSAQAFPQTDISISPALPELPLPSLCPLFWMEFKGHCYRFFPLNKTWAEADLYCSEFSVGRKSAKLASIHSWEENVFVYDLVNSCVPGIPADVWTGLHDHRQVRKQWPLGPLGSSSQDSILI
What are the official names of this protein?
C-type lectin domain family 19 member A.
What are the subcellular locations of this protein?
Secreted.
Protein: YICS_SALTY
Sequence: MKRKTLLLIATLVALPGVTYADSPFSSLQSAHEKNTILKDLRKMCTPKGALTDEAWEKKIMASEGNQQHIREAMIAIERNNQHNYWQALGKVECPEM
What are the official names of this protein?
Uncharacterized protein YicS.
Protein: ATG1_CHAGB
Sequence: MSERTSSSRRSKPASDDTIGNFVIDKEIGKGSFAQVYSGRHKVTGALVAIKSVELARLNTKLKDNLYGEIEILKRLRHPHIVALHDCVESRTHINLIMEYCELGDLSLFIKKRDKLITNPGTHELARKYPVAPNSGLNEVVIRHFLKQLTSAIRFLREANLIHRDVKPQNLLLLPSPQYREANKMHKQILSASHDSFTPAAGLPSLPMLKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMATGRPPFRAVNHVDLLRKIEASGDVIRFSRECVVSSEVKGLVRALLKRNPVERISFEDFFHHPVITGPIPGLVEDDIPKPEKPVLAETKSRIRRANPELSHTRRSRAGPHLLATPIEPKPNPLEQVASPRLSYSPRQEADEGLGIRRPLAQPSTSAPVRPISYVDRSRRYSNASTKVPARDTPPPPHEGSNRSRPKSAVSRPLTDEDKAAQDVAFERDYIIIDKTAVEVNALADQISLYPQQGQPKSGGQIVRRATQQGHPTSTTGAVPSHPGRNAQGGRNDHYRKASHDKTLSGSPGATTSVISKAIQDASLRLFGFKYSPQMLSKGQSPPQIYSPFPAYPTPSTPAGLIMDGKQSAPVDEDSRVAQCIEDYATRSDVVYGFAEVKYKQLVPLAPSVEHGLGGVPTDRMGEEEEGLTMDAVVSLSEEALVLYVKALSLLAKSMDIASLWWSRKSRPESSNNVHSATRDSVNTQALVLKINAAVQWIRSRFNEVLEKAEIVRLRLVEAQNQLPEEHPSHPSNRPPETSALGGSSGGQATFPSVGISAEKLMYDRAVEMSRTAAINEIASEDLPGCEISYVTAVRMLEAVLDSDDDHLPKRRVSTSSKEEQSVAAQDASDDMSSDDKQAVQKMVQMINTRLTYLRKRMHTIAAASKAQQQQQQQQVVVRRRSGDVTPRSVPT
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
What are the official names of this protein?
Serine/threonine-protein kinase ATG1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: CH60_ACISJ
Sequence: MAAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASKTNDIAGDGTTTATVLAQAIVREGSKYVAAGLNPMDLKRGIDKAVVALVEELKKASKATTTSKEIAQVGSISANSDESVGKIIADAMDKVGKEGVITVEDGKSLENELEVVEGMQFDRGYLSPYFINNPEKQAAILDNPFVLLFDKKISNIRDLLPTLEQVAKASRPLLIIAEDVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQAKRIEVGKENTTIIDGAGAAADIEARVKQIRIQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALLRAKQAVGNLSTGNPEQDAGIKLVLKAVEAPLREIVANAGGEPSVVVNEVLNGKGNYGFNAANDTYGDMLEMGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDESAAPAMPGGMGGMGDMGM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_ECOHS
Sequence: MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RPOZ_BEII9
Sequence: MARVTVEDCIDKVENRFELVLLASHRARLIASGTPITVERDNDKNPVVALREIADETLTPEDLKEDFIQSLQKHVEVDEPEAEAVPALSSAPDAAQSDAMGDVQFDRMTEEDLLRGLEGLVPPAATDDDGE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: TRAF1_MOUSE
Sequence: MASSSAPDENEFQFGCPPAPCQDPSEPRVLCCTACLSENLRDDEDRICPKCRADNLHPVSPGSPLTQEKVHSDVAEAEIMCPFAGVGCSFKGSPQSMQEHEATSQSSHLYLLLAVLKEWKSSPGSNLGSAPMALERNLSELQLQAAVEATGDLEVDCYRAPCCESQEELALQHLVKEKLLAQLEEKLRVFANIVAVLNKEVEASHLALAASIHQSQLDREHILSLEQRVVELQQTLAQKDQVLGKLEHSLRLMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVDTSA
What is the function of this protein?
Adapter molecule that regulates the activation of NF-kappa-B and JNK.  Plays a role in the regulation of cell survival and apoptosis.  The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14.  The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).
What are the official names of this protein?
TNF receptor-associated factor 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_PSYIN
Sequence: MSFISKIRCAFTLGQGVLIENEALKETNDPILFFNNWLKKAQDTGIILPESMSISTCTPEGRPSSRMVLLKEVDSKGFVFFTNYDSRKAHDLEANPFAALLFHWNILQRQVRIEGRVERISTAQSNAYFQSRGRGSRIGAWASHQSQELNDRQTLVERVKYFEEKFAGKEIPLPEFWGGYRVIPESIEFWQGKADRLHDRFVYQPTEKNWTVKRLNP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RS13_FLAPJ
Sequence: MARIAGVDIPKNKRGVIALTYIFGVGRSRAIEVLEKAQVSQDKKVQDWNDDEIGGIREAVSFYKIEGELRSEVSLNIKRLMDIGCYRGIRHRSGLPLRGQRTKNNSRTRKGKRKTVANKKKATK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: NEF_HV1H3
Sequence: MGGKWSKSSVVGWPAVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAANNAACAWLEAQEEEKVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWRYKLVPVEPEKLEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: SYY_BACTN
Sequence: MNFVEELRWRGMLQDIMPGTEELLNKEQVTAYLGIDPTADSLHIGHLCGVMILRHLQRCGHKPLALIGGATGMIGDPSGKSAERNLLNEETLRHNQACIKKQLAKFLDFESDVPNRAELVNNYDWMKEFSFLDFVREVGKHITVNYMMAKDSVKRRLNGEARDGLSFTEFTYQLLQGYDFLHLYETKGCKLQMGGSDQWGNITTGAELIRRTNGGEVFALTCPLITKADGGKFGKTESGNIWLDPRYTSPYKFYQFWLNVSDSDAERYIKIFTSIEKEEIEALVAEHQQAPHLRALQKRLAKEVTIMVHSEEDYNAAVDASNILFGNATSESLRKLDEDTLLAVFEGVPQFEISRDALAEGVKAVDLFVDNAAVFASKGEMRKLVQGGGVSLNKEKLEAFDQVITTADLLDGKYLLVQRGKKNYFLLIAK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.