PharMolix/UniProtQA huggingface dataset:
Protein: ATPE_STRM5
Sequence: MSTIRCDIVSAEQEIFRGEATLVVATGELGELGIAPKHAPLITRLKPGKVVVTTPNGEQLDFAISGGILEVQPQVVTVLADTAIRAQDIDEASVRKAKEEAERILANRGEAMEVAEAQQKLAEAVVQLQALERLRKTLKH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YCSN_BACSU
Sequence: MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGITTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTSKSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNFKDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVFTENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAINALSYKLDQDQWFRIFTAVQGYDIP
What are the official names of this protein?
Uncharacterized oxidoreductase YcsN.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Protein: IDI_BURM1
Sequence: MEERLILVDTDDRPIGICEKMRAHHEGLLHRAFSIFVFDSAGRLLLQQRALNKYHSGGLWSNTCCGHPRPREALPDAVRRRLGEEMGFACELRPVDALVYRARFENDLIEHEFVHIHVGRFDGTVAPDFAEVAAWRWIDVPTLLEWMADEPSAFTVWFHCMIERAGLPVLHRWAHR
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_RIPO1
Sequence: MSRTYKATGIILKGMPIGEADRLVTILSPEWGLIRAVVPGARKSKSRLRGRSELFVINDLLIAKGRSLDKITQADTLESYPKLSQELGKLASGQYLAELVLCLAVSEQPQGELYELLKEHLRRLEDISSGQSLHSHLAQAVFHLLAIAGIGPQVHRCCLTQETLAANFSDPRWRVGFSFEGGGLINLSPQNPPQTPVPRINQELGAIELCLLQHLGYSFLPQPRQILPPESLNDFLGVAWVRLELLLRNYAQYHLGRSFRSAELVDTLSGLEF
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RL27_MOUSE
Sequence: MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  Required for proper rRNA processing and maturation of 28S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
60S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL27 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: ATPO_CANGA
Sequence: MFSRVFVRAASNAAKAGVKPPVKLFGVEGTYASALFTAASKETSVESASSSLVKLSSLIKEDAKLKHIMENPALSTKDRAVVVDSLVKSSANLDKPVVNLLKVLAENNKLGLFDKISSQFSILNDAHNGLIRGSVTTAQPLDSKNFKRLEKALQQSSLVGQQKTLKLDNVVKPDIKGGLIVEVGDQTIDLSVSSKIQKLNKVLEETI
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
What are the official names of this protein?
ATP synthase subunit 5, mitochondrial, ATP synthase chain 5, Oligomycin sensitivity conferral protein, OSCP.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: DPHB_SULIK
Sequence: MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEADRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTANEALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKWMLMS
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: FMT_PARPJ
Sequence: MSHSLRVIFAGTPEFAAAALAAIHSAGFQVPLVLTQPDRPAGRGMKLQASPVKRYAQEHGLAVAQPPSLRRVGKYPAEAAAAIDQLRATPHDVMVVAAYGLILPQEVLDIPLLGCINIHASLLPRWRGAAPIHRAIEAGDAETGITLMQMDVGLDTGAMISEARTAITADDTTATLHDRLAQDGAKLIVEALIELERTGKLAATPQPAEGVTYAEKIGKHEAALDWRRPAAVLARQVRAFDPFPGGVATLEDGTSIKLWAAVARDTQANGAPGTITDVSPEGVVVACGEGALRLTQLQKPGGKRLPVREFLAGSTLAVGQRFQLPETK
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: M2_I97A1
Sequence: MSLLTEVETLTRNGWGCRCSDSSDPLVVAASIIGILHLILWILDRLFFKCIYRRFKYGLKRGPSTEGVPESMREEYRQEQQNAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: CINA_BACAH
Sequence: MNAEIIAVGTELLLGQIANTNAQFLSEKLASIGINVYYHTVVGDNNKRLQQAIEVAEGRADMLIFTGGLGPTKDDLTKETIASSLAEELVYDEKALASISDYFKRTGREFTENNKKQALVLDGATVFANDHGMAPGMGLNKNGKVYILLPGPPKEMKPMYVSYVEPFLRNFTTGENIYSRVLRFFGIGESQLEVKVQDLIDGQTNPTIAPLANDGEVTLRLTAKHQNVDEAEKLIQHVEDLILERVGEFFYGYDQEFLHDKAIELLKKKGLTLSCAESLTGGLFGNQVTESAGVSSVFKGGVICYHNDVKQHVLHVPEEVLFTDGAVSKECARYLAENVKELLEADIGISFTGVAGPDASEHKEPGTVFVGLAIKDEPTVVFPLNLSGSRQQIRERSAKYGFYHLYKKLEEI
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: FTSQ_ACIC5
Sequence: MAKTTRHNSDSQRGLTLVEEDFLDEFEDAVPPVPSAANLRAAEPGPRAQARTRRPLPPSPEDSGLEEEPFLRVRRRVPVRSGPLPSWTKHRWGKILLASLFLLALGLILFVVLAVRHFLDHDPRFEISSAASIQTMGNSELSRADLLSVFGSDIGRNIFFVPLGERAAQLESIPWVKHATVMRILPDQLRVSIVERTPVAFLRIGSRISLIDAEGVVLDMTPELMAKHHFDFPVITGIDPAIPLAMRAQRMQLYLHFLSALNSDSQHVIDQVSEIDLADPEDVRATFNYGGHELLLHFGYTNFAARYRNYASHIQTWEQLYPRLASIDLRYDDQVVLRMATPPAPPAKLDAKPASPAAHSHGRKAAHHKVRRVIRHAHPTHHATRRAR
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: CLPX_AROAE
Sequence: MTDKKAGGEKLLYCSFCGKSQHEVRKLIAGPSVFICDECIELCNDIIRDEIAETVDAEGTRTTLPTPQEICEILNQYVIGQTQAKRNLSVAVYNHYKRLRHLSGRKEEVELSKSNILLIGPTGSGKTLLAQTLARLLNVPFVMADATTLTEAGYVGEDVENIIQKLLQKCDYDVDKAQHGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASIPPQGGRKHPNQDFIQIDTTNILFICGGAFDGLEKVIRNRTEKIGIGFGAEIKSREGKNVSESFRQVEPEDLIKFGLIPEFVGRLPVVATLQELDEEALIQILVEPKNALVKQYQKLFSMEGVDLEIRPAALHAVARKAIRRKTGARGLRSILESALLDIMYDLPTLEGVEKVVVDEGTIEEGAQPLLMYAEQPKVSGSN
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: NAGB_STRP3
Sequence: MKIIRVQDQIEGGKIAFTLLKDSLAKGAKTLGLATGSSPISFYQEMVKSPLDFSDLTSINLDEYVGLSVESDQSYDYFMRQNLFNAKPFKKNYLPNGLATDIEAEAKRYDQIIAEHPIDFQVLGIGRNGHIGFNEPGTSFEEETHVVDLQESTIEANSRFFTSIEDVPKQAISMGIASIMKSKMIVLLAFGQEKADAIKGMVFGPITEDLPASILQKHDHVIVIVDEAAASQLD
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: DNCH_GLOC7
Sequence: MMIYYRTVRLGDTDAAGVVYFATALSICHEAYEASLEQAYINLRKFFNDPEQAIPIVHGEIDFFRPLFCGEKLEIHLLARQLKDSEFEIEYQIFKGSSEGEKAARALTRHVCINPISRQRSRLPDLMVQWLARINTTESERLY
What is the function of this protein?
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA hydrolase, DHNA-CoA hydrolase, DHNA-CoA thioesterase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
Protein: FB19_ARATH
Sequence: MSYLLRSDPVSRIHPEPQSLTSFDHFDLLPDSLLLLIFDKVADVKDLGRCCIVSRRFHSLVPFVENVLVRVDCVISDDDSSSSDENHRFSLNTASISDAGGAGGSFSALFRLVFAPIFKPFQMLGQILGPKRSSSSFDASFSAINDEIGVTHHSPTQVLKNFGEIRFLKIELPTGELGIEDGILLKWRADFGSTLDNCMILGASSVIQSNSVKNHENSVDEDNGNIPESFYTNGGLKLRVVWTISSLIAASARHYLLQPIINEHKSLDRLVLSDADGQGVLCMNREQLEELRVTPLSASSASKRTLVPALNMRLWYAPELDLPDGTVLKGATLVAIRPSESKKEVCDASWLSDAFEEPFGTVAKMLIKRRTYCLEMNSF
What are the official names of this protein?
F-box protein At1g30200.
Protein: COXX_BACC2
Sequence: MNHATSELHDESAVTSVPETTRIQDLKALVKMGIVNSNTLTVFTGFWLALHFNGLSVMDNLDKLFFTIVGSGLVMAGVCCLNNYIDRDIDPLMERTKTRPTVTGKYKPGFALTFGLVILLLGFVFLLLTTPMAVLMGFIGAFTYVVLYSLWTKRKYTLNTVVGSISGAVPPLIGWAAIDPSLGHPIAWMLFLIMFIWQIPHFLALAMKRVDEYRNAGIPMLPVVHGFEITKRQIMIWTVCLLPLPFYMSGLGITFMVIATLLNIGWIVLGFYGFRKKDDIKWSVQMFVYSLNYLTILFVSMIVVTFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MROH9_HUMAN
Sequence: MLTRNPKTKSSLQILQDSVKWHHMAHKVNSLLDAYSGLLSNESMILAVNSSFVDPLLQFESQLKIIESSFGMLVVMPSLDKVKEMGSSYEYIEDMENLYHNILNIYENILTSLVSKDLYKLQILKEMLVWMSKDSSYLQERIMVIINKVLRFTVTKVRKYISVDAPCLGLLAAELSLLCSHEDPSIVKQASLGMCHLLYIARCQNDIGTNKPTNGKSHSLQFPSSDVEFLPKEFQQDESKIAQRVGQTLLPPLLTDFVQSLLMKLSSPDDKIASDAASILIFTLEFHAEKVTMVSKIVDAIYRQLCDNNCMKDVMLQVITLLTCTSPKKVIFQLMDYPVPADDTLIQMWKAACSQASVAPHVLKTILLILKGKPGEMEDTVTEGKRFSLDITNLMPLAACQALCTFLPLGSYRKAVAQYFPQLLTTLMFQVFYNSELKPILKDRALYAQDALRVLLNCSGLQQVDITLMKENFWDQLSEDLCYYHGVCFIAKTLSEYNFPQFPETLSYLYKLSVEGPRRSEDTVIVLIFLTEVSFVDCEQLCSHFLFLPKFKSKFQFLVSLPLNVGSYQDLRS
What are the official names of this protein?
Maestro heat-like repeat-containing protein family member 9.
Protein: METH_BOVIN
Sequence: MAPTLQDLTPSAGMKKTLQDEIEAILQERIMVLDGGMGTMIQRHKLSEEDFRGQEFKDHARPLKGNNDILSITQPNVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEDISLQTGIKRYVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYKEQAKGLLDGGVDILLIETIFDTANAKAALFAVQKLFEEEYVPRPVFISGTIVDKSGRTLSGQTGEAFVISVSHADPLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPHVMAMHLKDFAVDGLVNIVGGCCGTTPDHIREIAEAVKNCKPRVPPATVFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRRFAKLIMAGNYEEALSVAKMQVEMGAQVLDINMDDGMLDGPSAMTRFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKFGAAVVVMAFDEEGQATETDPKIRVCTRAYHLLLKKLGFNPNDIIFDPNILTIGTGMEEHNLYAVNFINATKVIKETLPGAKVSGGLSNLSFSFRGMEAIREAMHGVFLYHAIKFGMDMGIVNAGSLPVYDDIHKELLQLCEDLIWNRDPEATEKLLHYAQTQGKGGKKVIQTDEWRNGPLEERLEYALVKGIEKYIIEDTEEARLNQEKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETKVLTGKIEDEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEILEEYEDIRQDHYESLKERRYLTLRQARENGFHIDWLSEPPPVKPTFLGTRVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFDDKTVGEEAKKVYDDAQNMLQALISQKKLQARGVVGFWPAQSIQDDIHLYAEGAVPQASEPIATFYGLRQQAEKDSASSDPYLCLSDFIAPLHSGIPDYLGLFAVACFGVEELSKAYEEECDDYSSIMVKALGDRLAEAFAEELHERARRELWGYCSGEQLAVADLRRLRYEGIRPAPGYPSQPDHTEKLTVWRLADVEQRTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQIEDYASRKNMSVAEVEKWLGPILGYDTD
What is the function of this protein?
Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol.  MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis.  Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate.  The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
What are the official names of this protein?
Methionine synthase, MS, 5-methyltetrahydrofolate--homocysteine methyltransferase, Cobalamin-dependent methionine synthase, Vitamin-B12 dependent methionine synthase.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 dependent methionine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGR_GEOSE
Sequence: MNKGQRHIKIREIIMSNDIETQDELVDRLREAGFNVTQATVSRDIKEMQLVKVPMANGRYKYSLPSDQRFNPLQKLKRALVDVFIKLDGTGNLLVLRTLPGNAHAIGVLLDNLDWDEIVGTICGDDTCLIICRTPKDAKKVSNQLLSML
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_BACC2
Sequence: MENAFKLLYKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKEMVDVFYHCFVLLAEKNIALEDVMREVKERNGKLSRVGDRREIDTL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_SHIBS
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVLLRDGEAFLFGANITPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRVNREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDIKEREWQVDKARIMKNAHR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: GLMU_VESOH
Sequence: MNNIHAIILAAGKGTRMNSTKPKVLQILSNNTLLEHVLSQVKTLCNKIHIAYGFEGKQVQQKINNPSINWVKQVKQLGTGHAVAQVMPYIEGNSISLILYGDVPLIKRSTLYDLINKTQQSGIALLSVILNNPTGYGRIIRNNKQIQAIVEQKDASNMQLNINEVNTGIMAINSQLLKQYLNEIDSRNTQGELYLTDIIACAAADKKTISSIISKNKFEVLGVNDKVQLAELERLFQKDQAIQFMKQGLGLKDPTRFDCRGTLTFGQNCEIDVNTLIKGKVALGNSTTIEPNCIIKNTIIGNHVSIFPNCVIEDAVIGEGVTIGPFVHIRPQTHIQTHAKIGNFVEIKKSTIGKNTKISHLSYVGDSTIGKNVNIGAGVITCNYDGVNKHQTIIADGAFIGSDSQLIAPIKIGKNAKIGAGSTITKSVSENQLSVSRTKQKNLKYRSKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGAL_HORVU
Sequence: TGVTYDHRALVIDGXXXVLVSGSIHYPRAASSWYAVET
What is the function of this protein?
Involved in cell wall degradation.  Degrades polysaccharides containing beta-(1-->4)-linked galactans, acting as an exo-(1-->4)-beta-D-galactanase (By similarity).
What are the official names of this protein?
Beta-galactosidase, Acid beta-galactosidase, Lactase, Exo-(1-->4)-beta-D-galactanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
Protein: YBEY_RUTMC
Sequence: MVVIQNIIHDSSINEYDLSNTLQEVIKELDRGESELLIRLVNETEIKNLNKVYRHQDKLTNVLSFQSDLPIEIDEAVLGDVVICTQVVLKESIEQHKSFNNHLTHMAIHGMLHLLGYDHIDTKDAQQMENLEIKILAKIGINNPY
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_NITSB
Sequence: MENIRNFSIIAHIDHGKSTLADRLIQECGAIEDRKMSDQVMDTMDIEKERGITIKAQSVRLTYKKDGKEYILNLIDTPGHVDFSYEVSRSLASSEGALLVVDASQGVEAQTIANVYIALENDLELIPVINKIDLPAADPERVKADIENTIGLDCTDAIEVSAKTGQGINELLDAIIERIPAPSGDPTAPTKALIYDSWFDSYLGALALVRVFEGEIKKGQEVLVMGTGKTHEVIDLMYPHPINPQKTSTIKTGEIGIVVMGLKNIGDVQVGDTITDAKNPTPEPIEGFEEAKPFVFAGLYPIDTDKFEDLREALNKLKLNDAAIAFEPETSAALGFGFRVGFLGLLHMEVVKERLEREFGLDLIATAPTVTYKVKKTDGETIEIQNPSELPPPQEIDTIYEPYVKATIITPTEFLGNVLNLLSEKRGVQLKMDYITQDRVMLEYEIPMNEIVMDFYDKLKTVTKGYASFDYEPSGYKEGDLVKLDIRVAGEVVDALSIIVPKEKAQYKGRELVKKMKELVPRQLFEVAIQASIGNKIIARETVSAMRKNVTAKCYGGDITRKRKLLEKQKEGKKRMKAIGKVQLPQEAFLSVLKID
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y456_METJA
Sequence: MKIDTFIFLMFISIGILLLLLNIINPMEVFHIVEWKTIFSLFYLMVIINIMRDTKFLDYISLKILKKSKRIFIALIFLTLFLSSLITNDVSLFVIIPLTLIIHRYTNMPFKDLEKLIIFEGVSANIGSGLTPIGNPQNLFLFHFYNIGTLEFIINMIPFEIFGILAILPFLEFKKYDTKINIDIKFKKEWIFYILSFILVLLCVFGYLNFIYILPLILAILMYKRVKVDYLFLLTFIFLFVDIEGLKRIGIINIFSIKCGNVMLMIYASLLSQIISNVPATVLLSHLYKNWLPIAYGVNIGGNGTLIASFANLITLRLSNGNVRVGRFLLIGGIIYIMHLIVLVAYAKIFWV
What are the official names of this protein?
Uncharacterized transporter MJ0456.
What is the protein family that this protein belongs to?
Belongs to the CitM (TC 2.A.11) transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNPH_LEGPH
Sequence: MRPSNREHDQLRPVTITRNFTNYAEGSVLVEFGQTKVICNASIVEGVPRFLKGKNQGWITAEYGMLPRATHSRTEREASKGKQGGRTLEIQRLIGRSLRACIDLKVLGENTITLDCDVIQADGGTRTAAITGSCVAMRDAIHWMVQREKIKKMPAFNYVAAVSVGIYRGQPVLDLDYAEDVLAETDMNVVMNEQGHFIEVQGTAEDNSFNREQLNSMLSLAEIGIPQLIEIQKNA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.