PharMolix/UniProtQA huggingface dataset:
Protein: SSRP_RICRO
Sequence: MTEYKKVIAQNKKALFHYFIEERLEAGIVLKGSEVRSLRQGKASIEESHAADTGHEVFLYNCHIAEYEKANRFNHATRRPRKLLLHTKEIKKIIGRIRIKGYTLVALSMYFNKKNKVKVELGIAKGKKLHDKRESIKEKDWKRDQSRLIRQK
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: VP2_FCVC6
Sequence: MNSILGLIDTVTNTIGKAQQIELDKAALGQQRELALQRMNLDRQALNNQVEQFNKLLEQRVQGPIQSVRLARAAGFRVDPYSYTNQNFYDDQLNAIRLSYRNLFKN
What is the function of this protein?
Minor structural protein present in one or two copies per virion.  Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).
What are the official names of this protein?
Protein VP2, Minor capsid protein.
What is the protein family that this protein belongs to?
Belongs to the vesivirus VP2 protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: CG13_CANAL
Sequence: MFPNSPDAFHQVRMMQSSIKASNFKLQSMEFRCHSNNVCEYQMEMLHHLLSVEAKTLPNLSLIEQQPEIKLGMRPLLLDFLMEVITILSLSRSTFPLTVNLIDRYCSTRIVKKQHYQLLGLTSLWISCKNLDSKFKVPTLNDLRKICVDSYYKELFVEMEKHILKSLEWVVNAPTFDAFIDLYSNLLISNSSNFEVANIIKKSSHKIKLFSNYIGELFQFYPNIYYDYTSSQIALIAILITVLTLKIPVDLISLLNFYNGLVKTEMFKSNVEQGAEDQFEEILSVDSFKSLFNKSFFKNLIKIIDNPPSSLKIKYFAENGKYSVLMKQLVTTASNTLKCILDPVPTTPKANSFVKHQQQQHHYHPRPPMSINTSMIPLTPVSNSTSPNRFSPDQIFSENESTPGIAFGTMTPDSQSTSPGEKRSYECIDELEIGTSTIAGYTLKNHDTLKRSKSANYGTLFYLQQ
What is the function of this protein?
G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition.  CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.  Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae.  Degradation is mediated by GRR1.  Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.
What are the official names of this protein?
G1/S-specific cyclin CLN3.
What is the protein family that this protein belongs to?
Belongs to the cyclin family.
Protein: IF1_CAMJ8
Sequence: MAKDDVIEIDGTVLEALPNANFKVELDNKHVILCHIAGKMRMHYIRIMPGDKVKVELTPYSLDKGRITFRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_CALS4
Sequence: MTVRKPEWLKVRILSEDLNRMEAFLKNMALNTVCQSANCPNMGECFARRTATFMIMGNICTRNCRFCAVEKGHPQPLDEEEPRRVAEAARRLGLRHVVVTSVTRDDLPDGGASHFAKTIYELKKLPGVTVEVLVPDFMGNEEAIRTVVEAKPDVINHNVETVPRLYSRVRPKADYIRSLNLLKKVKELDPLILTKSGIMVGLGETEEEVIEVMKDLRDIDCDMMTIGQYLRPSHKHIEVAEYVTPEQFKRYEEIGYKLGFKHVASGPLVRSSYHADVGLSLARG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_RHOP5
Sequence: MTKRSEAKYKIDRRMGQNIWGRPKSPVNRREYGPGQHGQRRKGKLSDFGVQLRAKQKLKGYYANISERQFHAIYVEATRLKGDSGENLIGLLERRLDTVVYRAKFVATMFAARQFINHGHVKVNGKRVNISSYKVKVGDLIEVKESSKQLAFVLEASQLGERDTPDYVEVDHSKMTAKFIRVPHLSDVPFAVQMEPHLIVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: NEUL3_MOUSE
Sequence: MGSLLSPEANAEVPREALSFHGNATGAQVHLDDQRSTARRRSTFHDGIVFSQRPVWPGERVALRVLRHEEGWCGGLRVGFTRLDPAQVAASCLPPFVCPDLEEQSPTWAALLPEGFVRAGNVVCFWVNRRGWLFAKVNAGRPLLLRKDVLVQGAPLWAVMDVYGTTKAIELLDPKANAWIRSGEPVPESEVISGEECVICFHNTANTRLMPCGHSHFCGSCAWHIFKDTARCPICRWQIEEVAVVSSLKAEEGS
What is the function of this protein?
E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:15936721, PubMed:35792897).  Seems to utilize UBE2E1.  Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897).
What are the official names of this protein?
E3 ubiquitin-protein ligase NEURL3, Lung-inducible neuralized-related C3CH4 RING domain protein, Neuralized-like protein 3, RING-type E3 ubiquitin transferase NEURL3.
Protein: MOAC_BRUC2
Sequence: MSGKLTHIDQTGAANMVDVGSKDETERQAVAEGAVRMKPETLALILEGNAAKGDVIGTARLAGIMAAKRTSDLIPLCHPLMLTKVAVEIEPDENLPGLRVRALARLKGRTGVEMEALTAASVTCLTIYDMAKAVDRHMEIGSIRVIEKSGRKSGDWAVSDPASMR
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: RIMO_CHLP8
Sequence: MATSNERKPAIFLLSLGCSKNTVDSERLTAQAVASGLTFTDDVDEASIILINTCGFIEDAKKESIDEMLAAIGKKEEGIVREVYVMGCLVELYRKELSEEMPEVDGWFGTRQLPDVLAAIGAHYCEELYDRRELLTPPHYAFLKISEGCNRRCSFCSIPKIRGPYVSQPIEQLLREAALLQEQGVRELNLIAQDISVYGYDLYGKPALNDLTLRLSDMGFDWIRLLYAYPLNFPLEVIDTMRQRRNVCNYLDMPLQHINDRILKSMQRGIGRKGTEELIDAIRQKNPDIRLRTTMIAGYPSETREEFDELLDFVRQARFDRLGCFPYRHEEHAPAYALEDTISDKEKEERVGELMELQESIAASLNRKLEGQTLTVLIDRIEDNVAYGRTEYDAPEVDNDVIIEIGDEAVEEGEFRQVTVEDSTAYELFGRVGSECS
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPW_BPP2
Sequence: MTARYLGMNRSDGLTVTDLEHISQSIGDILRTPVGSRVMRRDYGSLLASMIDQPQTPALELQIKVACYMAVLKWEPRVTLSSVTTARSFDGRMTVTLTGQHNDTGQPLSLTIPVS
What is the function of this protein?
Baseplate protein that is part of the outer wedges of the baseplate.  Probably plays a role as a connector between the central and peripheral parts of the baseplate.  Plays a role in tail assembly.
What are the official names of this protein?
Baseplate protein W, Gene W protein, GpW.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family.
What are the subcellular locations of this protein?
Virion.
Protein: UREF_PSEE4
Sequence: MNTDLALLRLLQLASPGLPVGGFTYSQGLEWAVEAGWVRSVAGFAAWQREQLHDTLGYLDWPVLARLYRACQADDAEVFAYWSRFLLANRETSELRLEETQRGSALARLLDGWQLGQDPAWRNGLELSQLGGMAWLGAHWAIPLRDLALGHGFAWLEGAVMAGVKLVPFGQQAAQTLLRDLGEELPAVLDHALVLDDEQLGGGLPLLAIASSRHETQYTRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQS3_CAEEL
Sequence: MPPKIHPSLSTGYFVSLDTMPPKNLCHQKVCHLGMKADLFALLKHAEIMKHIASFNVSVHGV
What are the official names of this protein?
Uncharacterized protein F21H12.3.
Protein: RNPH_CLOBB
Sequence: MRIDGRKNEQIRHVKVTRHYTKYAEGSVYIEVGDTKVLCNVSIEDKVPPFMKGTGSGWITAEYNMLPRSTETRKIRDIARLKIDGRTMEIQRLIGRALRSVVDLKALGEKTLWIDCDVIQADGGTRTTAISGAFIALVDAVNKLHKIKPFKIYPIRSFVAAVSVGIVNEEKILDLCYQEDSKAKVDMNIIMTDEGSFVEVQGTGEESPYTRAELNELLDLGEKGIKQMINVQKESLKMDSLWIGTGGNN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: AMER1_MOUSE
Sequence: MESQQDEAVQTKGASTSSDAQDQGAEKGAKNKTTEATEGPTSEPPLSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKVSSKKSLNKSKTHDGLSEASQGPEDVVIEETDLSTPLSKSSAQFPSSQSANGALEIGSKHKTSGTEAIEKAGVEKVPSVHKPKKSLKSFFSSIRRHRKGKTSGADQSVPGAKELEGARTRSHEHVSSISLPSSEEIFRDTRKENAKPQDAPGPKMSPAQVHFSPTTEKAACKNPEKLTRTCASEFMQPKPVLEGGSLEEPHTSETEGKVVAGEVNPPNGPVGDQLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDNDDEEEEEEEEEEEEEEEEEEEEEEEEEEEELLEDEEEVKDGEENDDLEYLWASAQIYPRFNMNLGYHTAISPSHQGYMLLDPVQSYPNLGLGELLTPQSDQQESAPNSDEGYYDSTTPGFEDDSGEALGLAHRDCLPRDSYSGDALYEFYEPDDSLEHSPPGDDCLYDLRGRNSEMLDPFLNLEPFSSRPPGAMETEEERLVTIQKQLLYWELRREQREAQEACAREAHAREAYARDTHTRESYGRNVRARETQALEAHSQEGRVQETKVRQEKPALEYQMRPLGPSVMGLVAGTSGGSQTSHRGTTSAFPATSSSEPDWRDFRPLEKRFEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRKAYPSYSPPEEPEEEEEEKEGNATVSFSQALVEFTSNGNLFTSMSYSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFNNDEDLTASLEAFELGYYHKHAFNSYHSRFYQGLPWGVSSLPRYLGLPGVHPRPPPAAMALNRRSRSLDNAESLELELSSSHLAQGYMESDELQAHQEDSDEEGEEEEGEWGRDSPLSLYTEPPGVYDWPPWAHCPLPVGPGLAWMSPNQLYEPFNQSSYVQATCCVPPVAMPVSVPGRTPGDSVSQLARPSHLPLPMGPCYNLQSQASQSGRAKPRDVLLPVDEPSCSSISGANSQSQAKPVGITHGIPQLPRVRPEPFQLQPNHYRASNLDLSKERGEQGASLSTSYSSTAMNGNLAK
What is the function of this protein?
Regulator of the canonical Wnt signaling pathway.  Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.  Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation.  Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane.  Promotes CTNNB1 ubiquitination and degradation.  Involved in kidney development (By similarity).
What are the official names of this protein?
APC membrane recruitment protein 1, Amer1, Protein FAM123B.
What is the protein family that this protein belongs to?
Belongs to the Amer family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2 (By similarity).
Protein: COX1_CARAU
Sequence: MAITRWFFSTNHKDIGTLYLVFGAWAGMVGTALSLLIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTTINMKPPAISQYQTPLFVWSVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKWETPMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAAFVHWFPLLTGYTLHSAWTKIHFGVMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYALWNTVSSIGSLISLVAVIMFLFILWEAFAAKREVLSVELTMTNVEWLHGCPPPYHTYEEPAFVQIQSN
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KMO_MYXXD
Sequence: MSEARKDTVTVVGAGLVGSLLSIYLARRGHTVELLERRPDMRRETVDGGRSINLAISTRGLHALRQVGLENEALKHAIPMRGRMIHPPQGELVYQPYGKDDSQHINAMSRGWLNAFLMTAAEATGKVRIRFKQRVTDVDFGSGALTVHDDATGEARQEPGRVVFGTDGSASAIRQALEKRPDFKGTQEQLGHGYKELTIPAGPGGAFQMEKHALHIWPRGTFMLIALPDEEGSFTCTLFLPWQGPVSFASLDTPAKLEAFFGAQFPDAKALIPDLVEAFFSRPTGSMVTVKGAPWHAGGQTLLLGDAAHAIVPFFGQGMNCGFEDCVVLDQLLGQGAGWEQVFTDFERLRKTNADAIADMAVENFVEMRDSTGDPRFLFRKAVEKVLLNAFPGEFVSRYSLVSFSHVPYRLAYQMGALTDGIVSELSEGLPRAEDVDLKRAAELIRSRLTPFMKEHADGFRTEG
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Protein: MURC_BURCH
Sequence: MKHIVKHIHFVGIGGAGMSGIAEVLVNLGYAVSGSDLSRNAVTDRLEALGARIAIGHDAANIEGANAVVVSTAVRSDNPEVLAARHQGVPIVQRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAAGGLDPTFVIGGRLISAGANARLGTGDFIVAEADESDASFLNLYPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGSAVVCVDDPNVRQIIPFISKPVVRYGLSPDAQVRAEDIDARDGRMHFTVIREGRAPLAVVLNMPGLHNVQNALAAIAIATDLGVSDDAIQLALAEFNGVGRRFQRYGEVPSADGGQYTLIDDYGHHPVEMAATIAAARGAFPGRRLVLAFQPHRYTRTRDCFDDFVNVLSTVDALVLTEVYAAGEAAIPTASGDALSRALRAVGKVDPVFVATVDDVPDALAKVAQNGDVVITMGAGSIGGVPAKLVQHIQQKA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARD1_DICDI
Sequence: MVSIRPCQIGDLMSMQNANLTCLPENYQMKYYLYHFLTWPQTSFVAEDDKGNVVGYVLAKIDENEPKRGHITSLAVLRSQRKLGIATKLMKQAEVALLEVYDADCVSLHVRKSNRAAFSLYHEVLKFKIDEIEKEYYGDKEDAYSMVLYLKPEVEEEKEREKQLEKINKAAKESIEAAKRANEEPKPVSNVIHGKKKNVKKIE
What is the function of this protein?
Seems to be involved in N-acetylation.
What are the official names of this protein?
N-terminal acetyltransferase complex ARD1 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ARD1 subfamily.
Protein: DPH1_HUMAN
Sequence: MAALVVSGAAEQGGRDGPGRGRAPRGRVANQIPPEILKNPQLQAAIRVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTEAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRVLYVFVDIRIDTTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAARQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPEVDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISWQQPYPMDFYAGSSLGPWTVNHGQDRRPHAPGRPARGKVQEGSARPPSAVACEDCSCRDEKVAPLAP
What is the function of this protein?
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:30877278).  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity).  Acts as a tumor suppressor (PubMed:10519411).
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1, Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, Ovarian cancer-associated gene 1 protein, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization.
Protein: DNAJ1_DROME
Sequence: MGKDFYKILGLERKASDDEIKKAYRKLALKYHPDKNKSPQAEERFKEIAEAYEVLSDKKKRDIFDNYGEDGLKGGQPGPDGGGQPGAYTYQFHGDPRATFAQFFGSSDPFGAFFTGGDNMFSGGQGGNTNEIFWNIGGDDMFAFNAQAPSRKRQQDPPIEHDLFVSLEEVDKGCIKKMKISRMATGSNGPYKEEKVLRITVKPGWKAGTKITFPQEGDSAPNKTPADIVFIIRDKPHSLFKREGIDLKYTAQISLKQALCGALVSVPTLQGSRIQVNPNHEIIKPTTTRRINGLGLPVPKEPSRRGDLIVSFDIKFPDTLAPSLQNQLSELLPN
What are the official names of this protein?
DnaJ protein homolog 1, DROJ1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP11_DAUCA
Sequence: MSIIPSFFGGRRSNVFDPFSLDVWDPFKDFPLVTSSASEFGKETAAFVNTHIDWKETPQAHVFKADLPGLKKEEVKVELEEGKVLQISGERNKEKEEKNDKWHRVERSSGKFLRRFRLPENAKVDEVKAAMANGVVTVTVPKVEIKKPEVKAIDISG
What are the official names of this protein?
17.8 kDa class I heat shock protein, Clone DCHSP17.7.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOA_PELPB
Sequence: MDQTLSNFGNVFAFLALGVVFVAGGYLTARMLRPSRPNPAKNSTYECGEEAVGSAWVKFNIRFYVVALIFIIFDVEVVFLYPWATVFKQLGEFALIEALVFAGILVLGLAYAWVKGDLDWVRPTPNIPKMPEMPSGKSGALRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRDB_LACLM
Sequence: MTENNRLSVKLPGLDLKNPIIPASGCFGFGEEYAKYYDLNKLGSIMVKATTLHPRFGNPTPRVAETASGMLNAIGLQNPGLEVIMTEKLPWLNENFPELPIIANVAGSEEADYVAVCAKIGDAANVKAIELNISCPNVKHGGQAFGTDPEVAAALVKACKAVSKVPLYVKLSPNVTDIVPIAKAVEAAGADGLTMINTLMGVRFDLKTRQPILANITGGLSGPAIKPVALKLIHQVAQVVDIPIIGMGGVANAQDVLEMYMAGASAVAVGTANFADPFVCPKIIDKLPELMDQYRIESLESLIQEVKEGKK
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.  Cannot use fumarate as an electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBT_PHOV8
Sequence: MKNFHIEYPDEGLREALIDKINNLTKPKGSLGVLEDLALQIGLIQQTLSPTLSHPHNVLFAADHGIVEEGVSKSPKEITWQQLSNFLHGGAGVNFLCRQHGFKLVLVDSGVDYDLPYEKGIINCSVGRGTHSFLKGPAMSMEEMELCLERGAKITDMIHADGCNVVSFGEMGIGNTSPSSVWMHLLTGISLEQCVGAGSGLDSEGIRHKYNVLKQSVDHYAGDGSAKDIIAWFGGYEMVMAIGGMLRAAELRMIILVDGFIMTNCILAASKLHPEVLSYAIFGHQGDETGHKLVLDAMKVRPLLNLGLRLGEGTGAICAYPIVVSSVNMMNEMDNFAHASITKYF
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RS20_ACIB5
Sequence: MANSAQAKKRARQNVKARKHNASLRSMVRTYIKRTLSAIAGGDYAVATEAYKKAVPVIDRMADKGIIHKNKAARHKSRLNAQVKALAN
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: BIOD_MYCBT
Sequence: MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAVALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIATVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN260_MOUSE
Sequence: MLESLQPESHLLHDEPDPGESVYECNECKETFSLEQNFVEHKKTHSGEKSPECTGCGEESSQASSLTLHLRSRPRRESYKCGECGKAFSQRGNFLSHQKQHTEERPSESKKTPVPMTTTVRNQRNTGNKPYACKECGKAFNGKSYLKEHEKIHTGEKPFECSQCGRAFSQKQYLIKHQNIHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKSNLTEHEKIHIGEKPYKCNECGTIFRQKQYLIKHHNIHTGEKPYECNKCGKAFSRITSLIVHVRIHTGDKPYECKICGKAFCQSSSLTVHMRSHTGEKPYGCNECGKAFSQFSTLALHMRIHTGEKPYQCSECGKAFSQKSHHIRHQRIHIH
What is the function of this protein?
Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling.  Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA.  Also acts as a cofactor with GATA4, a key cardiac regulator.
What are the official names of this protein?
Zinc finger protein 260, Zfp-260.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.