PharMolix/UniProtQA huggingface dataset:
Protein: BIOB_EMENI
Sequence: MSVSFTRSFPRAFIRSYGTVQSSPTAASFASRIPPALQEAVAATAPRTNWTRDEVQQIYETPLNQLTYAAAAVHRRFHDPSAIQMCTLMNIKTGGCSEDCSYCAQSSRYSTGLKATKMSPVDDVLEKARIAKANGSTRFCMGAAWRDMRGRKTSLKNVKQMVSGVREMGMEVCVTLGMIDADQAKELKDAGLTAYNHNLDTSREFYPTIITTRSYDERLKTLSHVRDAGINVCSGGILGLGEADSDRIGLIHTVSSLPSHPESFPVNALVPIKGTPLGDRKMISFDKLLRTVATARIVLPATIVRLAAGRISLTEEQQVACFMAGANAVFTGEKMLTTDCNGWDEDRAMFDRWGFYPMRSFEKETNAATPQQHVDSVAHESEKNPAAPAAEAL
What is the function of this protein?
Biotin synthase; part of the cluster involved in the biosynthesis of biotin (also known as vitamin B8 or vitamin H), a water-soluble vitamin that functions as a prosthetic group of many carboxylases, such as acetyl-CoA carboxylase and pyruvate carboxylase (PubMed:20713166).  Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism (By similarity).
What are the official names of this protein?
Biotin synthase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CYTIP_RAT
Sequence: MSLQRLLQQQSSNGNLEYCADSAYSSYPTLTGPLTVEDNRRIQMLADTVATLPRGRKQLALARSSSLGDFSCSQRKVVTVEKQDNGTFGFEIQTYRLQNQNICSSEVCTMICKVQEDSPAHCAGLQVGDIFANVNGVSTEGFTHKQVVDLIRSSGNLLTIETLNGTMIHRRAELEAKLQTLKQTLKKKWVELRSLHLQEQRLLHGDAANSPNLENMNLDESSLFGNLLGPSPAFLDRPRLSSESSCKSWLSSLTVDSEDDYGTSVSEDSIRGAFSRQTSTDDECFHSKDGDEILRNASSRRNRSISITSSGSFSPLWESNYSSVFGTLPRKSRRGSVRKQILKFIPGLHRAVEEEESRF
What is the function of this protein?
By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
What are the official names of this protein?
Cytohesin-interacting protein, Pleckstrin homology Sec7 and coiled-coil domain-binding protein.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome. Note=Recruited from the cytosol to endosomes by SNX27.
Protein: C85A2_ARATH
Sequence: MGIMMMILGLLVIIVCLCTALLRWNQMRYSKKGLPPGTMGWPIFGETTEFLKQGPDFMKNQRLRYGSFFKSHILGCPTIVSMDAELNRYILMNESKGLVAGYPQSMLDILGTCNIAAVHGPSHRLMRGSLLSLISPTMMKDHLLPKIDDFMRNYLCGWDDLETVDIQEKTKHMAFLSSLLQIAETLKKPEVEEYRTEFFKLVVGTLSVPIDIPGTNYRSGVQARNNIDRLLTELMQERKESGETFTDMLGYLMKKEDNRYLLTDKEIRDQVVTILYSGYETVSTTSMMALKYLHDHPKALEELRREHLAIRERKRPDEPLTLDDIKSMKFTRAVIFETSRLATIVNGVLRKTTHDLELNGYLIPKGWRIYVYTREINYDTSLYEDPMIFNPWRWMEKSLESKSYFLLFGGGVRLCPGKELGISEVSSFLHYFVTKYRWEENGEDKLMVFPRVSAPKGYHLKCSPY
What is the function of this protein?
Catalyzes the C6-oxidation step and lactonization in brassinosteroids biosynthesis (PubMed:15710611).  Converts 6-deoxocastasterone (6-deoxoCS) to castasterone (CS), and castasterone to brassinolide (BL) (PubMed:15710611).  May also convert 6-deoxoteasterone (6-deoxoTE) to teasterone (TE), 3-dehydro-6-deoxoteasterone (6-deoxo3DT, 6-deoxo-3-DHT) to 3-dehydroteasterone (3DT, 3-DHT), and 6-deoxotyphasterol (6-deoxoTY) to typhasterol (TY).  Seems also able to convert teasterone (TE) and typhasterol (TY) to 7-oxateasterone (7-OXTE) and 7-oxatyphasterol (7-OXTY), respectively (PubMed:18685225).  Catalyzes the conversion of 6-deoxo-28-norteasterone (6-deoxo-28-norTE) to 28-norteasterone (28-norTE), 6-deoxo-28-nordeoxoteasterone (6-deoxo-28-nor-3-DHT) to 28-nordeoxoteasterone (28-nor-3-DHT), 6-deoxo-28-nortyphasterol (6-deoxo-28-norTY) to 28-nortyphasterol (28-norTY) and 6-deoxo-28-norcastasterone (6-deoxo-28-norCS) to 28-norcastasterone (28-norCS) (PubMed:22170941).  Involved in a negative regulation of responses to abscisic acid (ABA) and drought tolerance (PubMed:27455172).
What are the official names of this protein?
Cytochrome P450 85A2, AtCYP85A2, 28-norcastasterone synthase, 28-nordeoxoteasterone synthase, 28-norteasterone synthase, 28-nortyphasterol synthase, 3-dehydroteasterone synthase, Brassinolide synthase, Brassinosteroid-6-oxidase 2, BR6ox 2, C6-oxidase 2, Castasterone synthase, Teasterone synthase, Typhasterol synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Endoplasmic reticulum. Note=Concentrates in endoplasmic reticulum subdomains adjacent to chloroplasts when farnesylated.
Protein: RS15_CROS5
Sequence: MSLTASEKQVLMSEYQVHETDTGSADLQVAILTKRITQLTDHLKQNPKDHASRRGLLKMIGRRRRLLGYINKKDSNRYQTLIKRLGIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PIG21_CLAP2
Sequence: MSAMSAMGKPEHGSATTSDLEHRATESSLEKQDVEAAPPGPVKPVDPSPKQSTLKTTLLLASVFLAMFLVAVDRTIISTAIPSITNDYNSLNDVGWYGSIYLLTCCAFQLLFGKLYAMYSARVVLLVSLVIFLAASALCGAAPNSEAFIVGRAISGVGSAGIFAGNIVAIVHTIPLAKRPKIQGLMGAVMGLATIIGPLIGGAFTTRVTWRWCFYINLPFGGLALVAIFFYFKVPNRSPAADLSLKQKILSLDIPGTILLVPAIVCLLLALQWGGQVYDWNNKYIIVLLTLMAVLFVAFIAVQICLPKTATVPPRLLMHRSVVAGFLTTIAIGSAQYIFVYYIPIWFQTVRGVNAVDSGIQLLPLMISFVVASIVGGLLNQRIGYYTALGIFGSSVMAVGAGLMTTWNLEISQGKVIGYQILFGFGMGLAFQTPNLAVQTVLPRPEVPMGIALMFFGQLLSAAIFVAVGQNILANQLLSRLAGIDGFEHLKSLILSGGVTAVIDAVPEESKHRVLVAYSDALQQVFIVGLAMSCVGVVGTSCMEWKNILKKPAPPAGPPAGAPTESAPVETKAAGHT
What is the function of this protein?
MFS-type transporter; part of the ergochrome gene cluster responsible for the typical purple-black color of the ergot sclerotia (Probable).  The ergochrome gene cluster produces several ergot pigments including the yellow ergochrome secalonic acid and its derivatives, as well as the red anthraquinones endocrocin and clavorubin (PubMed:28955461).
What are the official names of this protein?
MFS-type transporter CPUR_05422, Ergochrome biosynthesis cluster protein CPUR_05422.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNHD2_STAA8
Sequence: MLSNLLILPMLLPFLCALILVFLKNNDRISKYLYLGTMTITTIISLMLLIYVQRHRPITLDFGGWSAPFGIQFLGDSLSLIMVTTASFVITLIMAYGFGRGEHKANRYHLPSFILFLSVGVIGSFLTSDLFNLYVMFEIMLLASFVLITLGQSVEQLRAAIIYVVLNIIGSWLFLLGIGLLYKTVGTLNFSHIAMRLNDMGDNRTVTMISLIFLVAFSAKAALVLFMWLPKAYAVLNTELAALFAALMTKVGAYALIRFFTLLFDQHNDLIHPLLATMAAITMVIGAIGVIAYKDIKKIAAYQVIISIGFIILGLGTNTFAGINGAIFYLVNDIVVKTLLFFIIGSLVYITGYRQYQYLNGLAKKEPLFGVAFIIMIFAIGGVPPFSGFPGKVLIFQGALQNGNYIGLALMIITSLIAMYSLFRILFYMYFGDKDGEEVNFKKIPLYRKRILSILVVVVIAIGIAAPVVLNVTSDATELNTSDQLYQKLVNPHLKGED
What are the official names of this protein?
Putative antiporter subunit mnhD2, Mrp complex subunit D2, Putative NADH-ubiquinone oxidoreductase subunit mnhD2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EX7S_STRPN
Sequence: MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKELQATLDKAEKTLVKVMQEDGTESDFE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_YEAST
Sequence: MSVINFTGSSGPLVKVCGLQSTEAAECALDSDADLLGIICVPNRKRTIDPVIARKISSLVKAYKNSSGTPKYLVGVFRNQPKEDVLALVNDYGIDIVQLHGDESWQEYQEFLGLPVIKRLVFPKDCNILLSAASQKPHSFIPLFDSEAGGTGELLDWNSISDWVGRQESPESLHFMLAGGLTPENVGDALRLNGVIGVDVSGGVETNGVKDSNKIANFVKNAKK
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: HEM1_LISMC
Sequence: MFILTMGLNHHTAPIDIREKLVFKESEEEMALVTLQQEKSILENVIISTCNRTEIIAVVDQIHTGRYYLKRFMANWFQMDMEKIEPYLFFHEESDAVNHLYKVTAGLDSLVLGETQILGQVKHAFEIAKQTATTGTLLNKLFREVVTFAKKVHHHTKINENAVSVSYAAVEVAKKLYGSLDNKKIVLVGAGEMSELALQNLAGSGIADITIINRTKSNAELLANQFQAKVGAYENMNEHLMLADIVLVSTSAAEPIIKQAAMQDLMEQKASSMLVIDIGLPRNVEHDCSYIPNFHLYDIDDLAGVVSANSLERQRIVLELEKTIEAEVRNFFEWEKQLGVVPVIRALREKALDMQEVTMTSLENKLPGLTEREYIQIGKHMKSIINQMLKQPISELKEMSVEEDATTSIEHFKRIFGLSETDVTVIEKEQAETRS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: TPIS_SHESM
Sequence: MALRRPMVAGNWKMNGSAALAQELFKKFASKLQNDSAEVVLCPPSIYLESVRQLLEANKEALDGSLVRMGAQNLSQHDFGAYTGEVSGQMLKDCGCRYVIIGHSERRRMYGETSNIVAEKFAAAQKHGLTPILCVGESGPAREARRTFEVIAEELDIVIQKNGTMAFDNAIIAYEPLWAVGTGKSATPEQAQEVHAFIRKRLSEVSPFIGENIRILYGGSVTPSNAADLFAQPDVDGGLIGGASLNSSEFLSLCTIAMSA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUL3A_ARATH
Sequence: MSNQKKRNFQIEAFKHRVVVDPKYADKTWQILERAIHQIYNQDASGLSFEELYRNAYNMVLHKFGEKLYTGFIATMTSHLKEKSKLIEAAQGGSFLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKTHVHPMGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERIGEVIDRGLMRNVIKMFMDLGESVYQEDFEKPFLDASSEFYKVESQEFIESCDCGDYLKKSEKRLTEEIERVAHYLDAKSEEKITSVVEKEMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLVTVRDVMTSHLREMGKQLVTDPEKSKDPVEFVQRLLDERDKYDKIINTAFGNDKTFQNALNSSFEYFINLNARSPEFISLFVDDKLRKGLKGITDVDVEVILDKVMMLFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSEDTMRGFYGSHPELSEGPTLIVQVLTTGSWPTQPAVPCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTNMGTADIKAIFGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPAADLKRCLQSLACVKGKNVIKKEPMSKDIGEEDLFVVNDKFTSKFYKVKIGTVVAQKETEPEKQETRQRVEEDRKPQIEAAIVRIMKSRKILDHNNIIAEVTKQLQPRFLANPTEIKKRIESLIERDFLERDSTDRKLYRYLA
What is the function of this protein?
Component of the cullin-RING ubiquitin ligases (CRL), or CUL3-RBX1-BTB protein E3 ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  The functional specificity of the CRL complex depends on the BTB domain-containing protein as the susbstrate recognition component.  Involved in embryo pattern formation and endosperm development.  Required for the normal division and organization of the root stem cells and columella root cap cells.  Regulates primary root growth by an unknown pathway, but in an ethylene-dependent manner.  Functions in distal root patterning, by an ethylene-independent mechanism.  Functionally redundant with CUL3B.
What are the official names of this protein?
Cullin-3A, AtCUL3a.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
Protein: RSMH_RUMCH
Sequence: MEFKHTSVLLDECIEYLNINQEGIYVDGTIGGAGHSSEIYKRLGEKGCLVGLDQDSFAVETSIKRLDEIKSNADFKVVNTNFKNIKSACSGLGINEVDGILLDLGVSSHQLDEASRGFSYQHDAPLDMRMNTKSELSAYDVVNKYSEQDIYRIIRDFGEEKWASRIAKFITEARQNEPVETTYDLVDIIKKAVPSSARRDGPHPAKRTFQAIRIEVNNELGILNKTIEDCVDLLKRGGRLCIITFHSLEDRIVKMQYNKMVNPCTCPPAFPVCACGKKPKAVLINKKPIVSDIRELDKNPRARSAKLRVLQKI
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I72A4
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRFFEHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIEL
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: YTH1_CANAL
Sequence: MLQSNPVIHPNTSNRHFKFEPFLRQEYNFGLDPDRPVCQFYNPLNPDNSCPQGNNCPNKHVSAMYSNKIVCKHWLRGLCKKGDHCEFLHEYNLRKMPECLFYSKNGYCTQTSECLYLHVDPQSKIPECLNYNQGFCSEGPNCKNRHVRRVLCPLYLYGFCPKGPECEFTHPKFDFHNLNLRIRPDNLIQMTSKHVDNSKEESDKKEDSEPKEESI
What is the function of this protein?
Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
What are the official names of this protein?
mRNA 3'-end-processing protein YTH1.
What is the protein family that this protein belongs to?
Belongs to the CPSF4/YTH1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FLGB_CERS1
Sequence: MTGFRDQLGVHAQALVLRETRNNLLTSNIANAATPHYKARDIDFGAELARASGNGTLRTTEARHFAAGGPAARGEALYRDPVSPSLDGNTVEMAVEQMEFAENTLRYQTSLALLNRRISGLMTAIKGE
What is the function of this protein?
Structural component of flagellum, the bacterial motility apparatus.  Part of the rod structure of flagellar basal body (By similarity).
What are the official names of this protein?
Flagellar basal body rod protein FlgB.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: LEUC_BURP1
Sequence: MAQTLYDKLWNSHVVHTEEDGTALLYIDRQLLHEVTSPQAFEGLKLAQRPVWRISANLAVSDHNVPTTDRSHGIADPVSKLQVDTLDANCDAYGITQFKMNDVRQGIVHIIGPEQGATLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLLQKKSKNMLVKVEGQLPRGCTAKDIVLAIIGRIGTAGGTGYAIEFGGSTIRALTMEGRMTVCNMAIEAGARAGMVAVDDTTVEYLKGRPFVPTGAEWDQAVEYWKTFRSDEGAQFDRVVELDAAQIVPQVTWGTSPEMVTSIDGRVPDPEREKDPVKRDAMERALAYMALAPNTPIEAIKVDKIFIGSCTNARIEDIRAAAYVVKKLNRRVAPNVRLAMVVPGSGLVKAQAEREGLDKVFTEAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGQGGRTHLVSPAMAAAAAIEGHFVDIRRLG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: KPTA_FLAJ1
Sequence: MNENIAKSISKFLSLVLRHSPEKIGLKLDENGWADVNELIEKCTKKGNRLDAELLDYVVENNDKKRFAYNEDKTKIRASQGHSISVELNLAETEPLEYLYHGTVGKFMESIQKEGLKKMSRQHVHLSKDKETAVKVGSRRGVPQILTVRSGAMYRDGFKFYLSENNVWLTDEVPPKYIEFKS
What is the function of this protein?
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P).  May function as an ADP-ribosylase.
What are the official names of this protein?
Probable RNA 2'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: ACP_METPB
Sequence: MSDIAERVKKIVVEHLGVEPEKVTEASNFIDDLGADSLDTVELVMAFEEEFNVEIPDDAAETIQTVGDAIKFLEKNSA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VITH2_ARATH
Sequence: MDQSGSNTNMDIEKESTTFDYSKRSQWLRAAVLGANDGLVSTASLMMGVGAVKHDVKAMILSGFAGMVAGACSMAIGEFVSVYSQYDIEVAQMERDSVEIEKEKLPSPMQAAAASALAFSAGAIVPLLAAAFVKEYKMRIISVVVAVTVALMVFGWLGAALGKAPAVRSSARVLFGGWLAMAVTFGLTKLIGLYGL
What is the function of this protein?
Probable vacuolar iron transporter involved in the transfer of iron ions from the cytosol to the vacuole for intracellular iron storage (PubMed:25360591).  Involved in regulation of cellular iron homeostasis (PubMed:25360591).  Vacuolar iron storage is required for seed embryo and seedling development (PubMed:25360591).
What are the official names of this protein?
Vacuolar iron transporter homolog 2, Protein NODULIN-LIKE 2, Vacuolar iron transporter-like 2, AtVTL2.
What is the protein family that this protein belongs to?
Belongs to the CCC1 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: MUTS_HAEI8
Sequence: MISEENFQQHTPMMQQYLKLKAENPDILLFYRMGDFYELFYDDAKKAAALLDISLTKRGQSAGQPIPMAGMPYHAVEGYLAKLVQLGESVAICEQIGDPSTSKGPVERQIVRIVTPGTVSDEALLPERQDNLIAAVYQEKEKFGLATLDMTSGRFQLCEPADKETLRAELQRIVPVELLYCEEFNEMAAIEHCKGLRRRPIWEFELSTAITLLNRQFGTKDLRAFGVEKSPLGLSAAGCLLQYAKETQRTALPHIQSISLIQNQDCIQLDAATRRNLELTQNLSGGTENTLASVLDKCVTPMGSRLLKRWIHQPIRDVEKLKQRQQAIAEILNFDLVDELQPYLQLVGDMERILARVALRSARPRDLTRLRTALEQIPALRTIVQQKTSPFLTALFSQIADFSEQWDLLQRALIETPPLLIRDGGVIAEGYHAELDEWRMLSDGATQYLENLEKRERESTGIDTLKIGFNAVHGYYIQISQGQAHKAPIHYVRRQTLKNAERYIIPELKEYEDKVLKSKGAALALEKQLYDELFDLLLPHLGSLQLASLALSELDVLVNLAECADTLNYVMPTFCDEVSVKIENGRHPVVEQVLKDPFIANPVELNHNRHLLIITGPNMGGKSTYMRQTALITLLAYIGSFVPADSARIGPIDRIFTRIGASDDLASGRSTFMVEMTEMANILHQATEQSLVLIDEIGRGTSTYDGLSLAWACAEWLAKKIRSLTLFATHYFELTALPEQLEGIANIHLDALEHNNSIAFMHAVQDGAASKSYGLAVAALAGVPQSVIKLAKQKLTQLEKNSSYSAEQQIQALREANHNQGELLFEQETDALREAIEKLDPDDLSPKQALAYLYQLKKMVG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: GMHBB_SALTI
Sequence: MAKSVPAIFLDRDGTINVDHGYVHEIDAFEFIDGVIDAMRELKKMGYALVVVTNQSGIARGKFTEAQFETLTEWMDWSLADRDVDLDGIYYCPHHPQGSIEEFRQVCDCRKPHPGMLISARDFLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKPVTAEAENAADWVLNSLADLPSAIKKQQK
What is the function of this protein?
Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position in vitro.  Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7-bisphosphate and 2-deoxy-D-manno-2-octoulosonate-8-phosphate in vitro.
What are the official names of this protein?
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase, D,D-heptose 1,7-bisphosphate phosphatase, HBP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the GmhB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIRE_HYPVG
Sequence: MPKPWVVFGLGTLVLFLWRLNKIGRRPKNYPPGPPTLPLIGNLHLMPKKNAHLQFQRWAEEYGPVYSLMLGTKVAIVLSSDVAVKDLLDKRSSIYSGRPELYMGQEIMSGGNRPLFMGINSVWRRVRKLAHGLLNVKVSRTYVPYQDLESRDMLMGLLESPKDFLNHIRRYTTSLTTQMAFGYRTPSSDDKGLLEMFENFDELSRLTGSQSAAILDLYPIARILPDFLLPARRLGREYYEREKKLFMKHFLNARQQLNSGTSKPCCAIDLLRAQKEYGFSDEFGCYLSGSLLQAGSETTAIILTGFFQAMLVFPEVSKEAQEEIDRVCGDRLPDLNDYPNLPYIRACLKESLRWMPATALGVPHAVIQDDSYLGYHIPKDAGLILNVWAIHNDSKRHPDPRRYNPARWAGDNQNSAQAAVNPDPTKRDHFVFGAGRRLCQGMHIADRSLFLAISRTLWAFDLKRPVDKETGHEIIPDVDNIKDGLFISPMPFAADIVPRSESRAAAVRQEWENVAGLLDDDMQWKTVPEGLKWKDYEPLDDENEDLLESLS
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of virensols and trichoxide, fungal natural products that contain or are derived from a salicylaldehyde core (PubMed:31790246).  The pathway begins with the synthesis of the reduced chain in virensol C by the highly reducing polyketide synthase virA via condensation of one acetate and 8 malonate units (PubMed:31790246).  VirA has interesting programming rules since the first 2 ketides are fully reduced, the 3 following ketides undergo beta-dehydration, and the last 3 ketides are only reduced to beta-hydroxys to yield the trihydroxy portion (PubMed:31790246).  The production of aldehyde virensol C by virA alone is surprising, since virA does not contain a reductase (R) domain that is typically associated with reductive product release in HRPKS (PubMed:31790246).  The cupin-domain enzyme virC is involved in enhancing virA product turnover (PubMed:31790246).  The short-chain dehydrogenase virB then oxidizes the C-7 alcohol of virensol C to a ketone, yielding virensol D (PubMed:31790246).  Virensol D is further transformed to salicylaldehyde 5-deoxyaurocitrin by the short-chain dehydrogenase virD (PubMed:31790246).  VirD catalyzes the dehydrogenation of C-3 to form the beta-ketone aldehyde, which is followed by the generation of the nucleophilic C-2 that is required for the intramolecular aldol condensation between C-2 and C-7, itself followed by dehydration and aromatization which leads to salicylaldehyde 5-deoxyaurocitrin (PubMed:31790246).  While the dehydrogenation of virensol D is definitely catalyzed by virD, the aldol condensation and dehydration may be uncatalyzed or assisted by virD (PubMed:31790246).  The short chain dehydrogenase virG then converts salicylaldehyde 5-deoxyaurocitrin into virensol B which is further hydroxylated by the cytochrome P450 monooxygenase virE to yield the hydroquinone virensol A (PubMed:31790246).  VirI then may oxidize virensol A to form the quinone, while virH performs the epoxidation (PubMed:31790246).  Finally, the two remaining short-chain dehydrogenases, virK and virL, are probably responsible for reducing the ketones to the corresponding alcohols to furnish the epoxycyclohexanol structure in trichoxide (PubMed:31790246).
What are the official names of this protein?
Cytochrome P450 monooxygenase virE, Trichoxide biosynthesis protein virE, Virensol biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: Y1906_XYLFA
Sequence: MGRGPSIEARKNASDSKRGKIFTKIIRQIGVAARAGGGDPSNNPSLRVVIDKALASNMSKDVIERAIKKAIGEMEGVQYEEVRYEGYAPGGVAVIVDCLTDNRLRTVSDVRHAFSKCGGNMGTEGSVAFMFKRLGVLSYAHAIADEERITEAAIDAGAEDVMVYTEDDEIEVITTPEAFSRVKEEMAALGLMPYHAQITFRADSDIVVDGDTAIQVRKLLDILEDLDDVQDVYSNVDQVTLGKR
What are the official names of this protein?
Probable transcriptional regulatory protein XF_1906.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_CHLAB
Sequence: MDLFSPAKLNLFLKLHGKTSHGFHEMTTLYQVIDFGDRLSLESSSEDSLICNLPELNTPQNLIWKSIQVFRDYTQIYSPVAWRLYKCIPIGSGIGGGSSNAATALYALNQHFQTQLSNDVLQELGKKIGMDVPLFFSLGSALGIGCGEEILSYDNDHRDERYVLYFSDQPVLTKDAFSYVRPEDFSKREECLSLYARNNDLEQSVFRFRKDLEEKKHMLKRIWSPFNAHVRMSGAGATLFVSYSREIETDPSTAKALHATIHNSQGLLVNSLRKYNGWFEHGDNLLATTRQ
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.