PharMolix/UniProtQA huggingface dataset:
Protein: DNS2A_BOVIN
Sequence: MATLSSLLLTALLWVPVGTLTCYGDSGQPVDWFVVYKLPAHTGSGDATQNGLRYKYFDEHSEDWSDGVGFINSTTGAVGRSLLPLYRNNNSQLAFVLYNDQPPKSSESKDSSSRGHTKGVLLLDQEGGFWLIHSVPNFPPRASSAVYSWPPGAQKYGQTLICVSFPLTQFLDISKQLTYTYPLVYDHRLEGDFAQKFPYLEEVVKGHHVRQGPWNSSVTLTSKKGATFQSFAKFGNFGDDLYSGWLSEALGSTLQVQFWQRSSGILPSNCSGAQHVFDVTQTAFPGPAGPAFNATEDHSKWCVTPKGPWACVGDMNRNQREEHRGGGTLCAQMLWKAFKPLVKAWEPCEKKSRAYSLGSPAGLWT
What is the function of this protein?
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA.  Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation.  Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.
What are the official names of this protein?
Deoxyribonuclease-2-alpha, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II.
What is the protein family that this protein belongs to?
Belongs to the DNase II family.
What are the subcellular locations of this protein?
Lysosome.
Protein: GHRB_CITK8
Sequence: MKPSIILYKALPDDLLHRLEEHFTVTQVPNLRPETVEQHAQAFASAEGLLGSSETVNSALLEKMPKLRAASTVSVGYDNFDVAALNARSVLLMHTPTVLTETVADTVMALVLSTARRVVEVAERVKVGEWTKSIGPDWFGTDVHHKTLGIVGMGRIGLALAQRAHFGFNMPILYNARRHHPEAEERFNARYCDLDTLLQAADFVCLILPLTEETHHLFGAAQFAKMKSSAIFINAGRGPVVDETALIAALQSGEIHAAGLDVFEQEPLPVDSPLLSLPNVVALPHIGSATHETRYNMAACAVDNLIDALQGKVEKNCVNPQVAG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCRB_METBF
Sequence: MSDTVDIYDDRGKLLESNVDIMSLAPTRNAAIQSIIMDTKRSVAVNLAGIQGALASGKMGGKGRQILGRGLNYDIVGNADAIAENVKKLVQVDEGDDTNVIKVKGGKSLLIQSPKSRIIAGADFMSATTVGAAAVTQTIMDMFGTDPYDAPIVKSAVWGSYPQTMDLMGGQVQGILSIPQNNEGLGFSLRNIMANHVAAISNRNAMNASALSSIYEQSGIFEMGGAVGMFERHQLLGLAYQGLNANNLLYDIVKENGKDGTIGTVIESVVRRAIEAGIISVDKTAPSGYNFYKANDVPKWNACAAVGTLAATLVNCGAGRAAQNVSSTLLYFNDILEKETGLPGCDYGKVEGTAVGFSFFSHSIYGGGGPGVFNGNHVVTRHSRGFAIPCVCAAVALDAGTQMFSIESTSGLIGDVFGAIPEFREPIKAVAGVL
What is the function of this protein?
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB).  This is the final step in methanogenesis.
What are the official names of this protein?
Methyl-coenzyme M reductase subunit beta, Coenzyme-B sulfoethylthiotransferase beta.
What is the protein family that this protein belongs to?
Belongs to the methyl-coenzyme M reductase beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_CUPPJ
Sequence: MIDLGISKLALIGAVALIVIGPERLPRVARTVGALVGRAQRYINDVKAEVSREVELEELRKMRTEFEDAARDVERTIHKEVSEQTQALNEALGGIEPSAESGGGVSDFVPSWHSAHKAHNGRKSWRVKQGARPLWFKRQNNVRVWVQSGAARVKRHRPAAGRARSFFE
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ACSA_WOLSU
Sequence: MTQTHSTELFKPNRAFAKTARIKNLCEYEDLRLDAEEDFEGFWGKLAKEKIDWMEPFSKVLDESEAPFYKWFVGGKLNVCAQCLDRHLDTRKNKAAIIFEGELGDSRIITYRELFYEVKRTANLLKNKFNVKKGDRVVIYMPMIPEAAFMMLACARIGAIHSVVFGGFSAEALRDRIIDAEAKLVITADGAYRRGKPYMLKPVVDDALAEGACPSIEKVLIVIRNKEEINYVPGRDYIYNEMIGLESAHCPPEPMDAEDPLFLLYTSGSTGKPKGVQHNQAGYILWAQTTMEWVFDVKENDTYWCTADVGWITGHTYIVYGPLAMGATTVMYEGVPIYPDTGRWWKMIEHYRVNQFYTAPTAIRLLHKEGKEEPKKYNLSNLKVLGTVGEPINPDAWNWYYNEIGGGQCPIVDTWWQTETGGHMISPLPGATPIKPGCATLPLPGIFAEVIDEEGNPKPAGEQGYLCITKPWPSMIRNIWGDPKRYESSYFSTCKKNGKPVYFAGDGAIRDERGYITITGRMDDVINVSGHRLGTAEIESAIAKHPGVAETAVVSRLDEIKGESVYAFIVLKPGYEDNVAEELQLLKEINAVITREIGPLAKADTMLFVPGLPKTRSGKIMRRILRSIARGEEITQDTSTLEDPAIVQKIQQLA
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: ADD_ECOSM
Sequence: MIDTTLPLTDIHRHLDGNIRPQTILELGRRYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVREGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNRARDADWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKMFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: M1010_ARATH
Sequence: MIGGDSVEAIERRLLAKYPEGSPSAEIIEMARIEAEDLFEIKAQIIQRMALYDPTGDWMARGARALDNPRTTSGEESLERLYDIWKDLQETGPLSDEFSRLQEKVFLKKGGPGGDPIA
What are the official names of this protein?
Uncharacterized mitochondrial protein AtMg01010, ORF118.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL11_RALPJ
Sequence: MAKKIIGFIKLQIPAGKANPSPPVGPALGQRGLNIMEFCKAFNAQTQGMEPGLPVPVVITAFADKSFTFVMKSPPATVLIKKAAGIQKGSAKPHTDKVGKITRAQAEEIAKAKNADLTAADLDAAVRTIAGSARSMGITVEGL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SP100_PANTR
Sequence: EGDRGASKNWKLSIRCGGYTLKVLTENKFLPEPPSTRKKRILESHNNTLVDPCEEHKKKNPDASVKFSEFLKKRSEMWKTIFAKEKGKFEDMAKADKAHYEREMKTYIPPKGEKKKKFKDPNAPKRPPLAFFLFCSEYRPKIKGEHPGLSIDDVVKKLAGMWNNTAASDKQFYEKKAAKLKEKYKKDIAACRAKGKPNSATKRVVKAEKSKKKKE
What is the function of this protein?
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis.  Functions as a transcriptional coactivator of ETS1 and ETS2.  Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA.  Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion.  Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening.  May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis.  May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation (By similarity).
What are the official names of this protein?
Nuclear autoantigen Sp-100, Nuclear dot-associated Sp100 protein, Speckled 100 kDa.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Cytoplasm. Note=Accumulates in the cytoplasm upon FAS activation.
Protein: Y152_LACLM
Sequence: MTHTHDHEHDHNHEPDYITLVDENGNESLFQILITIDGQEEFGKNYVVLQPTEFEEDEQGLIDVLAYSFTENADGTEGDLQPIPEDAEDEWDMIEEVFNSFMDEQED
What are the official names of this protein?
UPF0473 protein llmg_0152.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: RADA_RICFE
Sequence: MTKDKKHYICSNCGNTSPKWSGQCFDCGVWGSIVEEIVSTNKAIVKTGSKQDFDKLSGHVAEQLRIPTPIGELNRVLGGGLVLGSAILIGGDPGIGKSTLLLQLAASNFASKMNCLYITGEESLDQIKLRAIRLNLTNYNTDILAATNLEDIIASIEANKNNIDLVVIDSIQTITTKELSSPPGTVSQIRICANELVNYAKQNNIIILLSCHVTKDGQLAGPKILEHLVDTVLYFEGDHNNHFRILRSYKNRFGGVGEIGVFEMCGSGLIEVTNPSELFLMKREQNVIGTSIFAGIEGSRPLLMEVQALIVPSNMVTPRRSAVGWDANRLSMILAVLSSRIGLNLANYEVYLSIAGGLKIADPASDLAVAASLISAATGKPVPEHSVFFGEISLSGEIRKTAKAETRIKEAVKLGFNKIICSKLENLTYDFISSVSHLKDLKEIIR
What is the function of this protein?
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks.  Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster.  Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB.  Does not have RecA's homology-searching function.
What are the official names of this protein?
DNA repair protein RadA, Branch migration protein RadA.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RadA subfamily.
Protein: ESXB_CORDI
Sequence: MSQGFKTEADVMRNTAHRVDDTNQEVSAELSRLRSIVDGVRASWEGTAQVSFDNLMQRWDASAKGLQDALQSISDNIRGNATSFENVEADNQSAFSAVGGQGLAL
What are the official names of this protein?
ESAT-6-like protein EsxB.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. CFP-10 subfamily.
Protein: MURE_GEOMG
Sequence: MRLEDLARVINPSEAGGSLALEIEGLYCDSRQVRSGGLFFALRGVATDGHDYIVASRDRGAVAVVVEDPSRVPEGMTWLKVDDARLAMSRAAAAFYGNPTDGIPVVGITGTNGKTTTTYLVEAVMARAGIPVAVLGTISYRFGDKTIPAPHTTPESVDLQRTIRDLVDRGAQGVVMEVSSHALEQRRVDGCRFDVGVFTNLTRDHLDYHRDMESYFESKARLFTELLAADDTKPRRAAVINVDDPYGARLASDAVAPVVSYGLSPSVMVRAEMVTFSVDGISGTLVTPLGTIPFHSRLLGRFNLYNILAAVAAGVALGLSPDAIRGGIEGDVRVPGRLERVDNDHGITVLVDYAHTGDALENVLKTVAEIATGRIITVFGCGGDRDRGKRPVMGEIAGRFSDLSIVTSDNPRTEDAGAIIGEILGGIRSLGLREYGAEELITGFDAKGFAAVESRREAIRLAARVARPGDVLLLAGKGHEDYQIIGTMKHHFDDREEVAAAFRELSSKGQG
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDS5C_ARATH
Sequence: MSDSDKELENQIIEAGEKLIDPPSSLDELLSFLDKLFVSLAEVEQSPPDSMQNALTPLMKGLVGGKLFKHSDVDVKVAVAACISEITRITAPDAPYDDDQMKEVFKLIVSSFEDLVDKSSRSYAKRISILETVAKVRSCVVMLDLECDALLIEMFQHFLKAIRDHHSGNVFSSMENIMTLVLEESEDIPSEMLSPILHSVKKDDEISQVSRRLAEQVLSNCASKLKTYLTEAVKSSGVPLDKYSNIVASICEGTFSALQQDQVVANEKEDSQGHIKRETEVEKAAEISTPERTDAPKDESGKSGVSNGVAQQNDSSVDTDSMKKQDDTGAKDEPQQLDNPRNTDLNNTTEEKPDVEHQIEEKENESSSVKQADLSKDSDIKEETEPAELLDSKDVLTSPPVDSSVTAATSSENEKNKSVQILPSKTSGDETANVSSPSMAEELPEQSVPKKTANQKKKESSTEEVKPSASIATEEVSEEPNTSEPQVTKKSGKKVASSSKTKPTVPPSKKSTSETKVAKQSEKKVVGSDNAQESTKPKEEKKKPGRGKAIDEESLHTSSGDNEKPAVSSGKLASKSKKEAKQTVEESPNSNTKRKRSLGQGKASGESLVGSRIKVWWPMDQAYYKGVVESYDAAKKKHLVIYDDGDQEILYLKNQKWSPLDESELSQDEEAADQTGQEEDASTVPLTKKAKTGKQSKMDNSSAKKGSGAGSSKAKATPASKSSKTSQDDKTASKSKDSKEASREEEASSEEESEEEEPPKTVGKSGSSRSKKDISSVSKSGKSKASSKKKEEPSKATTSSKSKSGPVKSVPAKSKTGKGKAKSGSASTPASKAKESASESESEETPKEPEPATKAKSGKSQGSQSKSGKKRKR
What is the function of this protein?
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex (PubMed:26648949).  Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin (PubMed:26648949).  May couple sister chromatid cohesion during mitosis to DNA replication (By similarity).  Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (PubMed:26648949).
What are the official names of this protein?
Sister chromatid cohesion protein PDS5 homolog C, Precocious dissociation of sisters protein 5-C, AtPDS5C.
What is the protein family that this protein belongs to?
Belongs to the PDS5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSIE_SALTY
Sequence: MMPLSRSRLEFIATILQNVLNLGLLTLGLILVVFLGKETVHLADALFAPEQASKYELVEGLVIYFLYFEFIALIVKYFKSGLHFPLRYFVYIGITAIVRLIIVDHKTPMDVLLYSAAILLLVITLWLCNSNRLRRE
What are the official names of this protein?
Protein PsiE, Mig-7.
What is the protein family that this protein belongs to?
Belongs to the PsiE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SP1L2_ARATH
Sequence: MGRGVSAGGGQSSLGYLFGSGEAPKLAAVNKTPAETESSAHAPPTQAAAANAVDSIKQVPAGLNSNSANNYMRAEGQNTGNFITDRPSTKVHSAPGGGSSLDYLFGGGSN
What is the function of this protein?
Acts redundantly with SPR1 in maintaining the cortical microtubules organization essential for anisotropic cell growth.
What are the official names of this protein?
Protein SPIRAL1-like 2.
What is the protein family that this protein belongs to?
Belongs to the SPIRAL1 family.
Protein: UVRB_TREPA
Sequence: MKEFKLHASFQPAGDQIAAIDALVRGLHAGARFQTLKGVTGSGKTFTVANVIARVQKPTLVISHNKTLSAQLYREFKGFFPDNAVEYFVSYYDYYQPESYVPARDLYIEKDASINAEINRMRLSATFSLMERRDVIVVATVSCIYGLGLPESWRDLRIHVEVNQCLDLEDLKRQLVSLQYERNDAVLECGRFRVRGDVIEIFPAYLEEFYRIECDWDRVVRIRRIHPVSGAVLREFEELTVYPAKHFVLKEDAIPRAMDRIRQELDERLVQLTQENKLAEAARLKTRTEYDLEMLGEMGYCHGIENYSAPIAGRKSGEPPVTLLHYFPKDFVLFVDESHVTLPQLGAMYEGDRVRKQNLIDFGFRLPCARDNRPLKDSEFEALLNQAVFISATPGVKERTQSVQIVEQLIRPTGLLDPCIEVRKTDGQIEDICQRVKACSARNERSLVLTLTKKMAEDLTDYFNGLGIRTKYVHSEIETIERVEILTSLRAGECEVLVGINLLREGIDLPEVAFIAILDANIVGFLRSTTSLIQIIGRAARNARGTVVMYADAISDAMREAIEETARRRKIQMAYNRAHGITPRTIKKSIEDILVREQEVKKDAARVQVAPLLRAADADVRTHAARKKMVQALRLHMKVCARELRFEEAALIRDKILQLQRQDEQNGV
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y483_TREPA
Sequence: MSIISRVCIPCAVLLFAQLHAKELVHVSQLKEQEARISWQEVPGAVSYRVLIRNAHGRIVTNAVATTRSYSFSRLRPGSYQYQIIAYDVLHRASASAWTSLSIEKVHKPKTGGITPSTIEHVVGGEAYTVVXDRXWTYEKGWTIALFPDDKADEAGAYVKPLSVSKNKEGNWMVAIPNAALKTGSYTLRAITPRNIYAEVRGILHVVLWRRPIFFYYDLSVGYAPVYRPQDHAATINGVSDFFKICSPIGFVGTFEMCFFKRNSSTISAGFNAQMHSDSKQVDVKLDGNFAYLYELYPRIEVGGMLGLGYSLPFGQRKEDDSMYSYVTGTMKYFFTNSIYLRVQQQHMLTVKPSFTGVSLQQTPSLSFGYRFHN
What are the official names of this protein?
Uncharacterized protein TP_0483.
Protein: MACB_PSEPK
Sequence: MATPLIELCDIRKAYGGVDTPRVEVLRGISLRVHAGEFVAIVGASGSGKSTLMNILGCLDRPSAGSYRFAGKDVAELDSDELAWLRREAFGFVFQGYHLIPSGSAQENVEMPAIYAGTPAAERQARASALLGRLGLASRTANRPHQLSGGQQQRVSIARALMNGGHIILADEPTGALDSHSGAEVMALLDELASQGHVIILITHDREVAARAHRVIEIRDGLVISDSAADQPPAHAHKGIQAEELRQRLDRGATQHGAWKGELLESLQAAWRVMWINRFRTALTLLGIIIGVASVVVMLAVGEGSKRQVMAQMAAFGSNILYLNGSPPTLREPAGRITLDDVAAIGELPQVKHIMPVLGEKMMVRHGNNSQQFYVGGNNTFFPEIFNWPAVEGSFFTETDEASSAAVAVIGQKVREKMLAPGSNPIGQYLLIGNVPFQVVGILAGKGASSGDQDSDGRIVVPFSAAAIRLFGHRDPDYIAIAARDSGQVKDTEAAIDRLLRQRHQGKHDFELTNDAALIQAEARTQNSLSLMLGAIAAISLLVGGIGVMNIMLMTVRERTREIGIRMATGARQRDILRQFLSEAIMLSMVGGLTGIALALVVGASLTLADIAVAFALPAIVGAFACAVITGVVFGFMPARKAARLDPVKALTSE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y3802_BACFR
Sequence: MDWLQDLLWNPNSVAHIVFLYAFVVAAGVYLGKIKIFGVSLGVTFVLFAGILMGHFGFTGDTHILHFIREFGLILFVFCIGLQVGPSFFSSFKKGGMTLNMLAVGIVVLNIAVAMALYFILGGRIELPMMVGILYGAVTNTPGLGAAQEALNQLSYSGPQIALGYACAYPLGVVGIIGSIIAVRYIFRINFAKEEENWNQETDGTHHKPHLMSLEVHNEAIYGKTLGTISSFLGRPFVCSRIRKNGHVSIPNHGTILEQNDQLFVVCSEEDSDAIVAFIGREVQVDWEKQDMPMVSRRILVTKPEINGKKLGMLNFRSMYNVNITRVNRSGVDLFANPNLILQVGDRVMVVGSEDAVERVASVLGNSLKRLNEPNIITLFVGIFLGILCGSLPIAFPGMPTPVKLGLAGGPLVVAILIGRFGHKLHLVTYTTQSANLMIREIGIVLFLASVGIEAGANFVDTVIHGDGLLYVGCGFLITIIPLLIIGVIARSYYKINYFMLMGLIAGSNTDPPALAYSNQATGSDAPAVGYSTVYPLSMFLRILAGQMILLLMM
What are the official names of this protein?
Uncharacterized transporter BF3802.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM3_STRMK
Sequence: METVRIATRKSPLALWQSEHVADRLRQAHPGLHVELVPMSTRGDEVLDRSLAAIGGKGLFLKELELAMLRGEADCAVHSLKDVPMELDPPFALPAMLTRHDPADGFVSNLYASLDALPIGARVGTSSLRRQAQLRALRPDLELLDLRGNVNTRLAKLDNGGYDAIVLAVAGLERLGLGERIVARLQPPQWLPAPAQGAVAVECDGGNARLMALFAPLDDAATRACVEAERAMNRALHGSCHVPVAAIAQWQGDDLHLQGLVGSASDGRAVRAEAVGPANDPEGLGQRVAKLLLDDGAGELLNV
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: AMYM_GEOSE
Sequence: MKKKTLSLFVGLMLLIGLLFSGSLPYNPNAAEASSSASVKGDVIYQIIIDRFYDGDTTNNNPAKSYGLYDPTKSKWKMYWGGDLEGVRQKLPYLKQLGVTTIWLSPVLDNLDTLAGTDNTGYHGYWTRDFKQIEEHFGNWTTFDTLVNDAHQNGIKVIVDFVPNHSTPFKANDSTFAEGGALYNNGTYMGNYFDDATKGYFHHNGDISNWDDRYEAQWKNFTDPAGFSLADLSQENGTIAQYLTDAAVQLVAHGADGLRIDAVKHFNSGFSKSLADKLYQKKDIFLVGEWYGDDPGTANHLEKVRYANNSGVNVLDFDLNTVIRNVFGTFTQTMYDLNNMVNQTGNEYKYKENLITFIDNHDMSRFLSVNSNKANLHQALAFILTSRGTPSIYYGTEQYMAGGNDPYNRGMMPAFDTTTTAFKEVSTLAGLRRNNAAIQYGTTTQRWINNDVYIYERKFFNDVVLVAINRNTQSSYSISGLQTALPNGSYADYLSGLLGGNGISVSNGSVASFTLAPGAVSVWQYSTSASAPQIGSVAPNMGIPGNVVTIDGKGFGTTQGTVTFGGVTATVKSWTSNRIEVYVPNMAAGLTDVKVTAGGVSSNLYSYNILSGTQTSVVFTVKSAPPTNLGDKIYLTGNIPELGNWSTDTSGAVNNAQGPLLAPNYPDWFYVFSVPAGKTIQFKFFIKRADGTIQWENGSNHVATTPTGATGNITVTWQN
What is the function of this protein?
Converts starch into maltose.
What are the official names of this protein?
Maltogenic alpha-amylase, Glucan 1,4-alpha-maltohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: KAD2_PHANO
Sequence: MAPTTDPAVNELKSTVHKLEQRIAELEGRLSGHGGGSSSAQESVRMILMGPPGAGKGTQAPRIKEKFCACHLATGDMLRAQVAAKTPLGREAKKIMDAGGLVSDEIMVNMIKTELENNQECAKGFILDGFPRTVTQAEKLDGMLEATQKPLQHAVELQIDDQLLVSRITGRLVHPASGRSYHKIFNPPKAPMTDDATGEPLIQRSDDNEETLKKRLSTYHAQTSPVVAYYQKTGIWKPVDASQDPGQVWKSLLKIFDDKAYVAGRSGSLLNKIGLKN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: CAPPA_PYRAR
Sequence: MMHIPRLMCTQHPDTTVKITTAEEVDEAIVAYTAYGCDEVMVDYEGKMTPYGQPKEIVMKAIRGDVPLGDEFYITVRLPNPKLEEFDRAMLSLEAALVANYFSRRYADAQAVRWVVLPMVEDFDTVILVRRMLRRKAEIYKSETGVDVGEVEVIPLIEDAFVQVKAKVIVGEVFKSEEAREVRVFLGKSDSAVRHGHLASALAIIYAMSKLKEFEAESGIRVRPILGMGSPPFRGALNNPRLAHLEVVQYAGYYTATIQSAVRYDTSLDEYVKVRESILNACCGTRGLVGEEVLPLIQEASAKYRSQAMKHVDKIAEVARLVPSTRDRVSWKEYGRSLLDGDRVVHMPRAIVYTSAWYAMGFPPTLIDAPLLLELAKSDKLDAVFKLLPTYKMELEYDYEFFDPQTARNYLSEELVYAAVELADYLGVEARPTPTYTALLKMPRSEPNIIALSKYRKFLG
What is the function of this protein?
Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 2 family.
Protein: PXL2A_RAT
Sequence: MSFLQDSSFFSMGMWSIGVGAFGAAALALLLANTDMFLSKPQKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAVVKEKVKREVEDFQPYFKGEIFLDEKKKFYGPERRKMMLMGLVRLGVWYNSFRAWKGGFSGNFEGEGFILGGVFVIGSGKQGVLLEHREKEFGDRVNLLSVLEAVKKIKPQTPASRQS
What is the function of this protein?
Involved in redox regulation of the cell.  Acts as an antioxidant.  Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation.  May affect bone resorption and help to maintain bone mass.  Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.
What are the official names of this protein?
Peroxiredoxin-like 2A, Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes, Protein PAMM, Redox-regulatory protein FAM213A, Sperm head protein 1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=Secreted from mature adipocytes but not from preadipocytes.
Protein: ZFPL1_CAEBR
Sequence: MGLCKCPKRKVTNLFCYEHRVNVCEFCLVDNHPNCVVQSYLNWLTDQDYDPNCSLCHTTLTQGETIRLNCLHLLHWRCFDDWAASFPPTTAPAGYRCPCCSQEVFPPINEVSPLIEKLREQLKQSNWARNALGLPVLPELNRPVKNIAPIPPPPPPQVKHVSYDDSPAQKEIPIHHNRSETPATHLEMEDTASYSVSNSDVTFARKKNFASESSSDTRPLLRQDRDADNEENKYKRRPTIDWMRGLWRAKHGTGVPEDRTSGRKMAIFVMFLALLALITIITVLKRAGYNGEHSSDPMFDPMANPNIRVAVDDSRLPHL
What are the official names of this protein?
Zinc finger protein-like 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the ZFPL1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.