PharMolix/UniProtQA huggingface dataset:
Protein: FOLD_MYCPN
Sequence: MSFDGKQLAHEILLTYKNRDWSQVKLVILQTNNDVSSDAFIRQKMNACNTLGAQSELIKYHESVTEKELLEKIQQLNTDPEVTGIILQLPVYPHLKQNKLLKAIDPYKDVDYLTGNCPLPIRSCVVEAVLILKEHFHHDFTNKQIVVVGLGVTGGGPIFHYLKETGHQVVGCDKHTPNTMELIKTADVVITAIGKPHFFKTTNFKPGVILYDVGVSRNVLNKLCGDIDPNGIEKVAKWWSPTPGGVGPFTVLAIMKNLWVLYEAHQRRI
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SYFA_STAHJ
Sequence: MTQNDSMAELKQQALVDINEAQNERELQDVKVKYLGKKGSVSGLMKNMKDLPNEEKPAYGQKVNELRQTIQKELDEKQELLKNEKLNQQLAEETIDVTLPSRQISIGSKHPLTRTVEEIEDLFLGLGYEIVDGYEVEQDYYNFEALNLPKSHPARDMQDSFYITDEILMRTHTSPVQARTMEKRNGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDKNIKMSDLKGTLELVAKKLFGADREIRLRPSYFPFTEPSVEVDVSCFKCKGKGCNVCKHTGWIEILGAGMVHPNVLEMAGFDSNEYSGFAFGMGPDRIAMLKYGIEDIRYFYTNDVRFLEQFKAVEDRGEA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_THIDA
Sequence: MQTLTVDLGDRSYPIHIGAALLTRADLVLPHLAQKRVMVVTNTTVGPLYLAQLKAALEAAGVRVAEVVLPDGEAYKNWETLNLVFDALLRERAERKTTLIALGGGVIGDMTGFAAACYQRGVPFIQIPTTLLSQVDSSVGGKTGINHPLGKNMIGAFYQPKLVLADAATLGTLPARELSAGLAEVIKYGLIWDVEFLAWLEANMDRLRALDAEAISHAIYRSCEIKAQVVAEDEREGGLRAILNLGHTFGHAIETGMGYGAWLHGEAVAAGMVLAAETSQRLGWLGEADVARTRALIRAAGLPDVAPNLGVDAYLEYMGHDKKVEGGKMRFVLLKKLGEAVITDAVPADVLTAVLTPPH
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APE2_CANAL
Sequence: MASNNTSQRSGFSSFFCRLKTYFCNHFLCLFVLSFFPLSFRRLCLLCHLCEKSNLWLSSDNSASVVKQEREVLPTNVKPLHYDLTIEPIFDNFTFKGEETIDFQVNEKTNFITLNSLEIEVQEAKIDGKSVTDISFDAGKQTVTFKFDDDLSTGSIAKLYIKFTGELNDKMAGFYRASYQEDGKTKYMATTQMEPTDCRRAFPSYDEPAAKSKFTISLIADKELVCLSNSSEKETVSLDGNKKKVTFQTTPLMSTYLVAFIVGDLRYISNDNYRVPIRVYSTPGTEHLGEYSANIAAQTLKFFDQQFGIDYPYDKLDMVAVPSFSAGAMENCGLVTFRTVDLLIDADNANVNTKQRVTEVVMHELAHQWFGDLVTMEFWDGLWLNEGFATWMSWYACNSLYPDWKVWESYVSDSLQHALTLDALRASHPIEVPVKRADEINQIFDAISYSKGSSLLRMISKWLGEDVFVKGVSNYLKKHKWGNTKTSDLWEALSEASGEDVVKVMDIWTKNIGFPIVKVEEIGNGEIKVTQNRFLATGDVKESEDKTLYPVFLGLKTSEGVDESSVLETRSKTIKLPTSDDFFKINGDQSGIYRTAYEPARWTKLGKAGVEGKLSVEDRVGLVADAGSLASSGFIKTSSLLDLVKSWSKESNYVVWNEILTRIGSIKAALMFEDEATKKALEIFTRDLISEKLKETGWEFSADDSFADQQLKSSLFASAANAEDPEAVAFAKEAFAKFIAGDKKAIHPNLRASIFNTNAKYGDEKTFDELYNIYRNPSSVEEKIAALRSFGRFTKPEILDKVTGLLLQTDIVKQQDIYIPMQGLRAHKLGVEKLWTWLSENWDQIYILLPPGLSMLGSVVTLGTSGFTKEEQKKKVEEFFAQKDNKGYDQSLAQSLDIITAKSKWTDRDAKSIYEWLEANEYTK
What is the function of this protein?
Metalloprotease that specifically hydrolyzes peptides with N-terminal alanine, arginine and leucine residues.
What are the official names of this protein?
Aminopeptidase 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: ATPA_STRP2
Sequence: MAINAQEISALIKQQIENFKPNFDVTETGVVTYIGDGIARAHGLENVMSGELLNFENGSYGMAQNLESTDVGIIILGDFTDIREGDTIRRTGKIMEVPVGESLIGRVVDPLGRPVDGLGEIHTDKTRPVEAPAPGVMQRKSVSEPLQTGLKAIDALVPIGRGQRELIIGDRQTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRQYGALDYTIVVTASASQPSPLLFLAPYAGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELLLLLRRPPGREAFPGDVFYLHSRLLERSAKVSDELGGGSITALPFIETQAGDISAYIATNVISITDGQIFLGDGLFNAGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRIDLASYRELEAFTKFGSDLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVTILYALTHGFLDTVPVDDIVRFEEEFHAFFDAQHPEILETIRDTKDLPEEAVLDAAITEFLNQSSFQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FIS_ACTSZ
Sequence: MLEQQRNPAEALIVSVLNSQSQVTNKPLRESVKQALKNYFAQLDGEDATDLYELVLSEVEHPMLDMVMQYTRGNQTRAALMLGVNRGTLRKKLKKYGMS
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: G1PDH_SULIL
Sequence: MNVKEHVISLPRRVFVGHDIIYDISIYFSQLGITSPFLIVTGTKYTKKIADRVIENLPKNAKYEVIEIDTATLDDVYKVEEVVKKVNPNILLGIGGGKVIDVTKYAAFRNNLEFVSIPTSPSHDGITSPFASIKGLQKPVSVKAKEPLAIIVDIEILSLSPRRLINAGIGDTIGKIIAVRDWRLAAKLRGEYYGDYTASLALMSAKHAFQCTKIINKDIKYGVRMLIEALISSGVAMGMAGSTRPASGSEHLFAHAVELLHPEGVLHGELVGLGTIIMAYLHGINWKIIRDRLKKIGFPVKAKDLGLSDEEVIKALTIAHTIRPERYTILGDRGLTWSSAEKIARVTKIID
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTHP_ECOLI
Sequence: MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKLMAELE
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I.  Phospho-HPr then transfers it to the PTS EIIA domain.
What are the official names of this protein?
Phosphocarrier protein HPr, Histidine-containing protein.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
Protein: GUAAB_SULTO
Sequence: MSFDPQKFVDEISPQLKEIVDGRAIAAVSGGVDSTTAAVLSYKILGDKVIPVMIDTGFLRENEAENVKNMLKDLMPLQVIDEREKFISSLEGMSDAEEKRKKFRQLFYDTLSRIVKEFNAKYLIQGTIAADWVETQGGIKTQHNVLVQLGIDTEKEWGFKVVEPLADLYKDEVRALAKYLGLPRDIYNRQPFPGPGLLVRVVGKLTREKLEILRKVTTTVEKNLSELNLSQYFAVIFDSAAEYNKELSNEVGCDVKVYKTLATGVKGDVRAYGNIAGIECRKDYESLREIMEKLTSYNITHVVVKIKDKNPEGIYTIGIRAVNTQDFMTADFAKINWNILEKIANEINDKKIKEVVYDITTKPPATIEYE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase.
Protein: NUOC_AZOC5
Sequence: MDETLKDLAAHVTGALPGAVVAHKIAYGELTLETTPDHILKLATFLRDDPSCLFTCIVDVCGADYPAREQRFEVVYHLLSLKQNARVRVKLSAGEETLVPSVTGIWPGANWFEREAYDLYGILFTGHPELRRLLTDYGFDGHPLRKDFPLTGFVEVRYDDELKRVVYEPVRLAQEFRNFDFLSPWEGVEYILPGDEKASSQPGAPAAPKAS
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YHD7_YEAST
Sequence: MYRSSISIQVFICVLFLPLDSGRPLIYMIDLSYICSDATVFSGKSRVIFFSNPICEHTRGNFYLFYLNYIINTFAPKNRGTRRCKPFGLHINCRKKIDCLHVQLSYILCKNKSRKRHMDAHAITLAWLAHALT
What are the official names of this protein?
Uncharacterized protein YHL037C.
What are the subcellular locations of this protein?
Secreted.
Protein: GCSP_SHIBS
Sequence: MTQTLSQLENSGAFIERHIGPDAAQQQEMLNAVGAQSLNALTGQIVPKDIQLATPPQVGAPATEYAALAELKAIASRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVASDVHPQTLDVVRTRAETFGFEVIVDDAQKVLDHQDVFGVLLQQVGTTGEIHDYTALISELKSRKIVVSVAADIMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEYKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPVGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAGVLARAEAAEINLRSDILNAVGITLDETTTRENVMQLFSVLLGDNHGLEIDTLDKDVAHDSRSIQPAMLRDDEILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYQQMIAQLADWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLTDLRAKAEQAGDNLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKKASQVAILNANYIASRLQDAFPVLYTGRDGRVAHECILDIRPLKEETSISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESESKVELDRFIDAMLAIRAEIDQVKAGVWPLEDNPLVNAPHIQSELVAEWAHPYSHEVAVFPAGVADKYWPTVKRLDDVYGDRNLFCSCVPISEYQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: Y2925_BORPE
Sequence: MPARASRPAPGLPARAGLGFKPEHYATLVEQPPDLGFFEIHAENYMVPGGPAHAQLAWLRERYAISVHGVGLSLGGHDPLDARLLAGHRQLQRRYAPDSISEHLAWSRHDGRYFNDLLPIVYDDAALRRVCAHIDQFQQCLGQPILLENPATYVRFEASHIDEAQFLCELVARTGCGLLLDVNNVYVSAVNHGFDARAYLARLPLAAVGEIHLAGHARQRDAHGRAVLIDSHDAPVDEAVWDLYEYTLALTGPVATLLERDGNIPPLAGLLAETGRVTACLARGLALAA
What are the official names of this protein?
UPF0276 protein BP2925.
What is the protein family that this protein belongs to?
Belongs to the UPF0276 family.
Protein: CHA9_LYMDI
Sequence: RAAVAADRGIIGGYGLGAPYGLAGGYGLEVPYGLAGYADYRYPAGACGIDAYGGIGEGNVAVAGELPVAGTTAVAGQVPIMGAVKFGGDVCAAGSVSIAGKCACGCGDYGYGYGLGAPYLY
What is the function of this protein?
This protein is one of many from the eggshell of the gypsy moth.
What are the official names of this protein?
Chorion class A proteins Ld9.
What is the protein family that this protein belongs to?
Belongs to the chorion protein family.
Protein: LPTD_PSEF5
Sequence: MALKSPAFRKKFPLLVTGSLLALQPLATSFVVAAEQYDCSVSASGGWACAPKTSAAQLPPRPVHDANSVSSSVATAADATGEEASGDKSKLVTEAKGRGLKSRSADYSHLDWVPREKLTAAQLAETGPYCSGSYIEPIRPGMNDKTNKSDAPTFIGAKASRYQQEEQVATLAGDVVMRQGSMQVEADEASLYQAENRGELSGNVRVRDNGALLVGDHADIQLDTGEAKVDNAEYVLHKSRVRGNALYAKRAENAIIRLKDGTYTTCEPNSNAWQLKGNNITLNPATGFGTATNVTLRVKDIPVLYTPYIYFPIDDRRQSGFLPPSFSTGSDTGFMLVTPYYFNLAPNYDATLYPRYMAKRGLLMEGEFRYLTKSSEGQFGAAYLNDDDTDRKKQTDYEKTRYMLNWQHKGGLDSRLMTEVDYTKISDPYYFQDLQTDQIGVKATDYVNQQGVVTYRGDDYTARLNVQAYELASVANITPYNKLPQITFNGALPYHPQGLDFTYETELVRFDRDLLTGNYTDKDGGPIDPVTGAVGTRRLDTNVAGLARANGDRLNLKPGVSLPLNWSYGYLTPSLKYMYTQYNLDLDGTGKEGIVAARNYATATGTRYVGGDYSRNQNRGVPIASLDGGLYFDRNTQWFGKNYRQTLEPRAFYLYVPEEDQKDIPVFDTGEPTFNYASLFRDNRFSGSDRVGDENKLSLGVTSRWIEDNGFQRQRISVGQALYFKDRTVQLPGIDYRTRADATSNVSPYALEYEYRYNRDWRATADYNWDPDSHSARSGSAMFHYQPEDNPNKVVNAGYRYRNDQIRYDQNSGTWKMGGDYGTPGQPGYVKDYYKIQQHDFSVIWPIVPQWNAISRWQYDYNRNRTLEAFGGFEYDNCCWKLRLISRYWVKYDEFSQNAPENEKGDRGIFLQIVLKGLGGVMGTKVESFLDKGIQGYREREDQAF
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: PETN_CHLRE
Sequence: MLAEGEPAIVQIGWAATCVMFSFSLSLVVWGRSGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, chloroplastic, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single- pass membrane protein.
Protein: LPOA_GLAP5
Sequence: MPTILVQSYGFRQKMKTIFIPTALALLLAACSGNKVTETLKNEAYGNSEFYINKAEQSRNIEEQQSYRLLAVRKLIEENKVVEAQNTFSEILVAKLNDEQKLEHRLLIAQLAALQGNTEAQGVLRALPQTLLSQSQRLRVYQTQARIAENQNDVIAAVNARALMDSYMTDTQSRQANNDKIWEMLRNANRGMLEKAVAGPGEIGLAGWLALVVAYNQNMSNPAQLPQVIEMWKQQYPNHSAVLLLPIELRNVSSFQQTQLNGVALLLPLSGDAKILGEIIKRGFDDAKGTTTMQVQVFDTDSAPINDLLMQAKQQGAQTIIGPLLKPRVDEMLTSPEISNINVLALNSTPNVRAVAKVCYYGLSPEAEARSAAERFLKDGLQHAVVVAPNGDFGTRSAEAFAQRWRQLTNRDTDIRYYNQAFEVTSLLQGSGIGQGSGLYALGTAEQLSDLKQSLDNSPLANQFPIYTSSRSNSPNNGPDFRLTMEGVKFSEIPLLSDPSSSEYKKAEQIVESDFSMMRLYAMGSDTWSIANKFNEFRQIPGYKVHGLTGVLSAGPNCNIEREMNWLQYRGGSIVDAN
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
What are the official names of this protein?
Penicillin-binding protein activator LpoA, PBP activator LpoA.
What is the protein family that this protein belongs to?
Belongs to the LpoA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: Y1469_STAAN
Sequence: MMDNKDYKKFYLIREDVLPESVVKTLKIKDALKSDPTLSIYDAVKQFDLSRSAFYKYRETIFPVDDKMLDHREFTLILYVTDIVGMLARVLDVISKLELSVLTIHQSIPMEEKATITLSLNAKSKETSVEDVIGALRNLDYVSKVELISMSM
What are the official names of this protein?
UPF0735 ACT domain-containing protein SA1469.
What is the protein family that this protein belongs to?
Belongs to the UPF0735 family.
Protein: UVRB_STRTD
Sequence: MKGKTMIDRKEDNQFHLVSKYEPSGDQPQAIETLVDNIKGGEKAQILKGATGTGKTYTMSQVIQRVNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYADSAVSLRPGQEISRDKLLNDLVDIQFERNDIDFQRGKFRVRGDVVEIFPASRDENAFRVEFFGDEIDRICEIESLTGRNLGEVEHLVLFPATHFMTNEEHMEEAIKNIMEEMEVQVNQFEAEGKLIEAQRIRQRTEYDVEMLREMGYTNGIENYSRHMDGRKEGEPPFTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQARKKMLVDYGFRLPSALDNRPLRREEFESHVHQIVYVSATPGDYEMEQTETVVEQIIRPTGLLDPEVEVRPTMGQMDDLLGEINARTEKGERVFVTTLTKKMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSDGHVIMYADKITESMQKAMDETARRREIQMAYNKEHGITPQTIKKEIRDLISITKTNEAEVAEDTVNYSAMNKKERQEAIKKLQKQMHEAAELLDFELAAQIRDMVLELKSMD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_CERS4
Sequence: MEPLVETVIEDGRWEELDLPALATRAAEATLAALDMPAEGFTLVVMGCDDARIAELNGAFRQKGKPTNVLSWPSEERASEEPGMAPEPPEPGDPEDPEPLGDVAIAFETCQREAAEQGKPVTDHVTHLLVHGVLHLLGYDHVEEADGDLMEATETRILAGLGVPDPY
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_LACLM
Sequence: MSRIGNKVIVIPAGVSVEVNGATVTVKGPKGELVRSFNENITLEIAENEITVKRPNDTKEMKMLHGTTRALLANMVEGVSNGFSKALEMIGVGYRAQLQGTKLVLSVGKSHQDEVEAPENIKFVVATPTSIVVEGISKEAVGQTAAYIRSRRSPEPYKGKGIRYVGEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: DXS_CHRVO
Sequence: MYPLLENINSPADLRLLPRTQLPQLAGELREFLVESVSKTGGHFASNLGSIELTIALHYVFDTPHDRLVWDVGHQTYPHKILTGRRERMHTMRQHNGLAGFPKREESEYDTFGVGHSSTSIGAALGMAVAAKTLGVDRKSVAIIGDGAMTAGQAFEALNNAGAMDTDLLVILNDNDMSISPNVGALNNYLAKLMSGRFYAAMREGSSKVLGIAPPLKEIASKVEEHVKGFFTPGTLFEEFGFNYIGPIDGHDVDVLVDTLKNIRSLKGPQFLHIVTKKGQGYKLAENDPVKYHGVTKFDPANGLASGKGGAGKPQYTQVFGDWLCDMAKLDKRLVGITPAMREGSGMVRFEKEHPDRYYDVAIAEQHAVTFAGGMACDGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVMFALDRAGLVGADGPTHAGAFDLSYLRCIPNMTVMAPSDENECRQLLYTAFQLDTPTAVRYPRGTGPGAEIQQQMAALPIGKGVVRRRGKQVAILAFGSMVHPALAAAEALDATVADMRFVKPLDAELIRKLAQTHELIVTVEENVVMGGAGSGCGEALQAMGLAVPTLHLGLPDDYVEHGDPALLLSLCGLDAAGIEKSIRERLAG
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RS12_PHOLL
Sequence: MATINQLVRKPRSMKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGYEVSSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQGRSKYGVKKPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: VPS41_DANRE
Sequence: MAEVEEQGRKLSEESTDESEEEDTEEEPKLKYERLTNGVTEILQKDAASCMTVHDKFLALGTHFGKVFLLDIQGNVTQKFEISSVKINQISLDESGDHVGICSEDGKVQVFGLYTREGFHENFDCPIKVVALHPQFSKSNNKQFVTGGNKLLLYERNWLNRWKTSVLHEGEGNITSVKWRGNLIAWANNVGVKIYDIGSKQRITNVLRDNTSLRPDMYPCSLCWKDNTTLIIGWGCSVKICAVKERDPTEMRDLPSRYVEIVSAFETEFFISGLAPLADQLVTLYYVKENSDHMEEEFRTRPRLDIIQPLPEGCEEISSDALTVRNFQENQCRDYRLEHSEGESLFYIISPKDIVVAKERDQDDHIDWLLEKKKYEEALMAAEISFKNIKRHDVQKIGMAYINHLVEKGDYDTAARKCQKVLGKNMDLWENEVYRFKTIGQLKAISQYLPRGDLRLRPAIYEMILHDFLKTDYEGFATLIREWPGELYNNMAIVQAVNEHLKKDPTNSILLTTLAELYTYDQRYDRALEIYLRLRHKDVYQLIHKHNLFSSIKDKIVLLMDFDKEKAVDMLLDNEDKISMDKVVEELKDRPELLHVYLHKLFKRDHHKGQKYHERQISLYAEFDRPNLLPFLRESMHCPLEKALEICQQRHFVEETVFLLSRMGNCRRALQMIMEELANVDKAIEFAKEQDDRELWEDLISYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILHDYNLQILLREGCKKILVADSLSLLQRMHRTQKKGVRVDEENICESCHTPILPSDTAQAFGVVVFHCRHMFHKECLPSPGSIPGIQYCNICSAKRRGPGSGILEMKK
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways.  Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 41 homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS41 family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasm, cytosol.
Protein: PG077_VACCP
Sequence: MAEFEDQLVFNSISARALKAYFTAKINEMVDELVTRKCPQKKKSQAKKPEVRIPVDLVKSSFVKKFGLCNYGGILISLINSLVENNFFTKDGKLDDTGKKELVLTDVEKRILNAIDKSSPLYIDISDVKVLAARLKRSATQFNFNGHTYHLENDKIEDLINQLVKDESIQLDEKSSIKDSMYVIPDELIDVLKTRLFRSPQVKDNIISRTRLYDYFTRVTKRDESSIYVILKDPRIASILSLETVKMGAFMYTKHSMLTNAISSRVDRYSKKFQESFYEDITEFVKENERVNVSRVVEYLTVPNITISSNAE
What is the function of this protein?
DNA-binding protein which binds to the hairpin form of the viral telomeric sequence.  Required for the production of mature virions (MV).
What are the official names of this protein?
Telomere-binding protein OPG077, Telomere-binding protein I1.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG077 family.
Protein: PGXB_ASPNC
Sequence: MYLLPLTLFLTAAFGVSIPRSPLIPGAQIVPASSTADLRAIGAQHHKYPDRETVTIRASRNALDDVSSDFLWGLKQANHGGRLLLKQGETYVIGKKLDLTFLDNIEVQLEGEIQFTNNITYWQANNFYYDFQKSITFWRWGGQDIKIFGSGVLNGNGQKWYDEFAGKQILVYNTFYRPILFLTDNATRISVEGITQLNSPCWTNFFVRTNDVSFDNVYIHAFSTNASSDPANTDGMDSLDVDGVSFTNMRIDVGDDCFSPKPNTTNIFVQNMWCNNTHGVSMGSIGQYAGEMDIIENVYIENVTLLNGQNGARLKAWAGQDVGYGRINNVTYKNIQIQNTDAPIVLDQCYFDINATECAKYPSAVNITNILFENIWGSSSGKDGKIVADLVCSPDAVCTNITLSNVNLTSPKGTAEIVCDDIQGGIGVDCVSDESVTR
What is the function of this protein?
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
What are the official names of this protein?
Probable exopolygalacturonase B, Galacturan 1,4-alpha-galacturonidase B, Poly(1,4-alpha-D-galacturonide)galacturonohydrolase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS12_ARTS2
Sequence: MPTINQLVRKGRTPKVKKTKAPALNGSPMRRGVCTRVYTTTPKKPNSALRKVARVRLNGGVEVTAYIPGVGHNLQEHSIVLVRGGRVKDLPGVRYKIVRGALDTQGVKNRKQARSRYGAKMEKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.