PharMolix/UniProtQA huggingface dataset:
Protein: CS1A_MOUSE
Sequence: MWCLVLFSLLASFSAEPTMHGEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGGIEEGRLCGQKTSKSPNSPIIEEFQFPYNKLQVVFTSDFSNEERFTGFAAYYTAIDINECTDFTDVPCSHFCNNFIGGYFCSCPPEYFLHDDMRNCGVNCSGDVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTMQREDFDVEPADSEGNCPDSLTFASKNQQFGPYCGNGFPGPLTIRTQSNTLGIVFQTDLMGQKKGWKLRYHGDPISCAKKITANSTWEPDKAKYVFKDVVKITCVDGFEVVEGHVSSTSYYSTCQSDGQWSNSGLKCQPVYCGIPDPIANGKVEEPENSVFGTVVHYTCEEPYYYMEHEEGGEYRCAANGRWVNDQLGIELPRCIPACGVPTEPFQVHQRIFGGQPAKIENFPWQVFFNHPRASGALINEYWVLTAAHVLEKISDPLMYVGTMSVRTTLLENAQRLYSKRVFIHPSWKKEDDPNTRTNFDNDIALVQLKDPVKMGPKVSPICLPGTSSEYNVSPGDMGLISGWGSTEKKVFVINLRGAKVPVTSLETCKQVKEENPTVRPEDYVFTDNMICAGEKGVDSCHGDSGGAFAFQVPNVTVPKFYVAGLVSWGKRCGTYGVYTKVKNYVDWILKTMQENSGPRKD
What is the function of this protein?
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.  C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity).
What are the official names of this protein?
Complement C1s-1 subcomponent, C1 esterase, Complement C1s-A subcomponent, Complement component 1 subcomponent s-A, Complement component 1, S subcomponent 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: ELMG_STROV
Sequence: MDRIEIPVLVVGGGLTGLAAAVFLRQQGVDCLLVERHRSTTFLTRASGINARTMELLRNAGLEETVIDRSLHLIEGKRWRELGQPADRIPWVVLRARDLADIERAVIVEEPSLDVADVSPTRAQWCGQDKLEPILRDEAVRRGADIRFHTRLDSFAQDADGVDAVIVDRGTGARTAVRSRYLIAADGVRSTVRQALGVTGTGHGSLGKAMSVLFQADFEPVLHGRRFVITYMANPQAPGVLQTFDENRWIFGFFCDAYGGGDAAFDTGRCADIVRTSLGIPDIPLDVQLVQPWEMSHHVADSYRSGRVFLAGDAAHVHPPAGAFGANGGIQDAHNLAWKLASVLHGRASDALLDTYHQERHPVGTEIAEQAWTRHTYRLDGDDELGRRLVDTKVVAAGYRYTSSAVLGAAYPTAIPHELALTGLPGQRVPHVWLDHDGRRVSTVDLAVDGFVLLARADGTPWADAAARLAATTGIPLTAHVVGKTLTDPADALAAATGLGEAGALLLRPDGFVAWRSDTSADDPEAVLDGVLARILART
What is the function of this protein?
Involved in the biosynthesis of elloramycin, an antitumor polyketide (PubMed:11325225).  In vivo, probably catalyzes the triple hydroxylation of 8-demethyltetracenomycin A2 (tetracenomycin B2) at positions C-4, C-4a and C-12a to give 8-demethyltetracenomycin C (8-DMTC) (Probable).  In vitro, catalyzes the triple hydroxylation of tetracenomycin A2 (TCM A2) to give tetracenomycin C (TCM C) (PubMed:11009387, PubMed:11325225).  Uses either NADH or NADPH as an electron donor and requires molecular O(2) (PubMed:11325225).
What are the official names of this protein?
Tetracenomycin B2 monooxygenase-dioxygenase, Tetracenomycin B2 oxygenase, Tcm B2 oxygenase.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: RSMA_ACIF2
Sequence: MQEGGLPRAKKRFGQNFLVQPQIVERIVAAIRPASGDHLVEIGPGPGALTKSLLRLLPQFTVVELDRDMIAGLRALAPPEQLRVLQADALEVDFAALAGAGNALRIVGNLPYNVATPLIFHILEHAEQVRDMHFMLQKEVVDRVVAMPGSKAYGRLSVMIQAYCAVESLFTVAPGNFFPVPKVDSAFMRLIPHRPGLLPPHLQAPFARIVATSFAQRRKTLANNLRGILSADDLRGLQIDPGSRAETLDQAAFFRLAEATVEQGNRS
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S45A1_RAT
Sequence: MIPPAGSTPPGEALIPSVAPQDFWRSPISGYSGSVTRHISHRANNFKRHPKRRKYIRPSPPPPPNTPCPIELVDFEDLHPQRSFWELLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLLLNGRDIGMALADTATNHKWGILLTVCGVVLMDFSADSADNPSHAYMMDVCGPVDQDRGLNIHALMAGLGGGFGYVVGGIHWDKTSFGRALGGQLRVIYIFTAITLSVTTVFTLVSIPERPLRPLGEKRTAMKSPSLPLPPSPPVLLEEGAGDTLPSTTATSLYASFSSPISPPSPLTPKYGSFISRDSSLTGINEFASSFGTSNIDSVLIDCFTAGHDNYLALPSSVPRQAISVSFPRAPDGFYCQERGLERREGPLTLGLDGDVLRVGSLDTSKPRASGILKRPQTLALPDVAGGNGPETSRRRNVTFSQQVANILLNGVKYESELTGSSEQSEQPLSLRRLCSTIYNMPRPVRNLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHASEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEECLSVRTLYFIAYLLFGLGTGLATLSRNLYVVLSLCTHYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFASLVSFLGCLYSSLCVTYEIPSADAADEERQPLLLNV
What is the function of this protein?
Proton-associated glucose transporter in the brain.
What are the official names of this protein?
Proton-associated sugar transporter A, PAST-A, Solute carrier family 45 member 1.
What is the protein family that this protein belongs to?
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: PLPHP_PONAB
Sequence: MWRAGSMSAELGVGCALRAVNERVQQAVALRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKILSLGPEIKWHFIGHLQKQNVNKLMAVPNLFVLETVDSVKLAGKVNSSWQKKGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSVDFQHAIEVGSTNVRIGSMIFGERDYSKKPAPDKCAADVKAPLEVAQEH
What is the function of this protein?
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
What are the official names of this protein?
Pyridoxal phosphate homeostasis protein, PLP homeostasis protein, Proline synthase co-transcribed bacterial homolog protein, Pyridoxal phosphate-binding protein.
What is the protein family that this protein belongs to?
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
Protein: AROQ_YERPP
Sequence: MSDKFHILLLNGPNLNLLGTREPEKYGYTTLAEIVSQLEIQAQGMDVALSHLQSNAEHALIDSIHQARGNTDFILINPAAFTHTSVALRDALLGVQIPFIEIHLSNVHAREPFRHHSYLSDIAVGVICGLGADGYNFALQAAVNRLSKSN
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: ENL15_ARATH
Sequence: MASSSLLVTIFLCISVFFFSSVNANEVTVGGKSGDWKIPPSSSFSFNEWAQKARFKVGDFIVFKYEAGKDSVLQVTREAYEKCNTTSPKASYTDGNTKVKLDQAGPVYFVSGTEGHCQKGQKLRLVVITPRNSAFSPGPSPSEFDGPAVAPTSGAAKLAGGFSVVFGLVLGLWAFFF
What is the function of this protein?
May act as a carbohydrate transporter (PubMed:24470637).  Required, together with ENODL11, ENODL12, ENODL13, ENODL14 and ENODL15, for male-female communication and pollen tube reception and burst at the synergid cell surface of the female gametophyte (PubMed:27524487).
What are the official names of this protein?
Early nodulin-like protein 15, AtENODL15, Phytocyanin-like protein ENODL15.
What is the protein family that this protein belongs to?
Belongs to the early nodulin-like (ENODL) family.
Protein: TRPA_STRPN
Sequence: MPKTLTEKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLANTDIALIPLVSLTTGIERQKELIEGAEGFIYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKALHQGEPIQDFIRQAVAYQK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: SYC_BLOPB
Sequence: MLKIFNTLTKKKEKFIPINAGKIKIYVCGVTVYDLCHLGHARTFIVFDSVIRYLRHCGYQVSYVRNITDIDDKIIKRAYENNETTQQLTNRMIQEMHLDLDALNILRPNYEPKVTEHIDIIIKFICLLISKKHAYTAPNGDIMFSVETMHNYGVLSNKENPPKIHDNILKIPNIKKNPMDFVLWKKTTYNNKLGEPCWSSPWGLGRPGWHIECSAMNYSIFGNQIDIHGGGSDLIFPHHDNEIAQSVCAHETSYANIWMHSGLLLLNYEKMSKSLNNFFTIRDILKHYDPETIRFFLMSAHYRSQLKYNDNNLKNAQTSLKRLYIALRDTNPTIQPNGGDNEGEYFISKFISKMNDDFNTPEAYSVLFDIAHRLNNLKIKGHSLLAQGMAATLKYLANIIGLLHQNPEIFLKKITLKHNKNRHFEKIQKLIQCREVARKNNQWELADSIRKKLTVMGITLEDGPTGITKWHFK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR4_XENLA
Sequence: MLRVGPGSLAITGGSRLLGHRVGSECCPFHLDCSLLEKQSAAPGQEGSADSHGSDKILAAAFSPSGEYFALTDDNKRLVLFRTKPAWEKISVRWVSRRCTALTFSPCGNHILVADKSGDVFSFSVPRALEQGRLELGHLSMLLDVTVSLDGKHIITCDRDEKIRVSCWGAPHVIMSFCLGHTEFVSQLLPLPGQEKLLLSGSGDGTLRLWEYESGKEVHSVTLRSLAHELEDQENKRFAVSRISCCSCNGIQLAVLCEGVPGIFLFSVSPEPRLTFTQYIALTHTPIDLDFDGSAFLWVLSGVREEPLLKYKELDDQWQSVSNDEELTRLTGIIQENWGDLEGAGAPESRFVGLYKAVFDNMATYLQKKELRLESEKRKAADGQVVLASKVQKTES
What is the function of this protein?
Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs).  In the METTL1-WDR4 methyltransferase complex, wdr4 acts as a scaffold for tRNA-binding.  Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop.  M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay.  Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs.  Also required for methylation of a specific subset of miRNAs.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4, WD repeat-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRF_HERAR
Sequence: MTFIDKLSAAWQTQNSQLCIGLDPDPAKFPAHLQGKPDAILDFCKAIIDATADAACSFKPQIAYFAALRAEDQLEEICKYLRERYPHIPVVLDAKRGDIGATAEQYAREAFERYGADAVTVNPYMGFDSVQPYLERQDKGVIVLCRTSNAGGSDLQFLDVGGQPLYQHVAHLVADKWNTNGQCALVVGATFPNELAQVRAIVGDMPLLIPGIGAQGGDIKATVEAGRTANGTGMMINSSRAILYAKPDEMFAQAARQVALETRDAINRFCV
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: RPOB_KARMG
Sequence: MKKIIKIRRFKFPFTKEKTINFASVRNKISYPDFLDIQIKSFTNFFCINYTYKNISNKGFYKVFIEYFPISDSKNKFIIDFISYKIYDPLYSIEECIKRGLTYNVYIRARFKIYRTRKRKITIENKRTKYFETIYQDVYFGTCPYMTPSGSFIFNGSERVIVSQLHRSPGVFFGQYDIPNLPKISYARIIPLKGSWIELSTDINNVMYIYLDIKKRLPITTLLRALGYTRDIDILNIFNLAEEVNINKVNYKKFLGRTLAARIFKTSYQKFEENDILLERNIKLKKYHIDIILYYKIKVISLYKKNEKNEKNLYYSIIHNTLKKDPTNSQKEANIYIYKELKDSFPKNDKKAKLFINKFFFDETHLGEVGRYKLNKTLKLDFPLKDQILNIEDIISIIENLIALCNNKKEVDDIDNLANRRVKTVGEQLYTQYTIGIARVSRIIKERINVKDNETLTPLELINSKTLTSVINSFFGTDELSQFMDQTNPLAEMTHKRRISSLGPGGLSRERAGFEIRDVNYSHYGRLCPIETPEGPNIGLISSLCVFAKINSMGFIETPYFKVKKGKVVINEAPIYISSDQEYGKLITQANAILNYKTGVLKNNIIVRVNADFPMVNYKKINYIDVSTNQIASISASLIPFLEHDDANRALMGSNMMRQSVPLLNPKAPIVGTGLEKHLAQYVNALIYAEGDGIVESVDANNIKVKYFNSEKEKLLSFEKRIKTYKLIKFRKTNQNTCLNIRPIVKKGMYVTKGQVLCEGFATQNGKLALGRNIKVAFMPFKGYNFEDAIVISEKVVREDWFTSIHIDEYSLEVRDTKLGMEEFTFDIPNFNEENKKKLDKYGIIKIGSEVKPGDVLIGRITPKKEGYPSSEENFLKAIFGKKVGTIKNTSLKADSSLFGVVIDTKIYSKFSSKEDEQKQFQIKKLNNKFMKNLKLLRKLLINKLILVLEGSVSEGILNSSYKEIIPKGKILNKLNLKKLLKNQEIIYQNWVNNKYKNNLVFKIIKFYYLKINELKIKLKRKKNRLLIGDEITSGIIKIAKVLIAKKRKLKVGDKMSGRHGNKGIVARIVKEEDMPYLEDGTSVDLVLNPLGVPSRMNLGQIYETILGWAGEKLGINFSTPIFDGASIEEISKYTDIANLPSFGNTYLFDGETGEKFDQPVTVGVIYMLKLNHMVDDKMHARSIGPYSLITQQPLGGKSKFGGQRLGEMEVWALEAFGAANILREILTVKSDDVKGRTKTYEAIVKRETIPNPGIPESFHVLLKELKGLGLSLKLEVIKKKEKKNQKIKVRIEIKEKDIIKYKKKVKEIKLKKLKELKEQLSKSNKKK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CENPQ_MACFA
Sequence: MSGKANASKKNFEQLKRNPKRKKDNEEVVLSEKKVRNTVKRNKNHLKDLFSEGQTKHTNLKQIKIAPNKRKTWQPLSKSTRDYLQTMMESVLRTILSDRIKDKEEIQYHLNFLKNRLLQLCETLKVPPKKMEDLTNVSRLLNMERARGKANEEGLALLQEEIDKMVETTELMTGNIQSLKNKIQILASEVEEEEERVKQIHQINTSGVLSLPELSQKTLKAPTLQKEILALIPNQNALLKDLDILHNSSHMKSMSTFIEEAYKKLNAS
What is the function of this protein?
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.  Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores.
What are the official names of this protein?
Centromere protein Q, CENP-Q.
What is the protein family that this protein belongs to?
Belongs to the CENP-Q/OKP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Protein: MIAA_NITHX
Sequence: MSGTNPGEADGGAADAVLIAGPTASGKSALALSLAERTGGIVINTDSMQVYRDLRIITARPTPDEEARVPHRLYGHVDADVNCSAGMWVADAAAALEEALAQNRLPIFAGGSGLYFKALTRGLSAVPPIPSQVRDDVRARLERDGAEALHAVLARRDPAAAQRLKPRDRARIARALEVVEATGRSLTDWHRDGLPPLLPPDKVRAIFLAPDREALYARIDARFGAMLAAGALEEVRALAERHLDPLLPAMKAHGVPALMRHLRGEISLEEAAEIGRADTRHYAKRQFTWFRHQLPEFRWTSPEEAEAQLSCVIPGPR
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RECQ_HAEIN
Sequence: MLDSPLLSKIIEKPTALSVLKSVFGYQSFRKGQEEVINAALNGQDALVVMATGNGKSLCYQIPALCFDGLTLVISPLISLMKDQVDQLQANGIEADFLNSSQTLEQQQQVQNKLISGQLKLLYVSPEKVMTNSFFQLISYSKVCFIAIDEAHCISQWGHDFRPEYTQLGGLKASFPDAPIMALTATADYATQQDILRHLNLKNLHKYIGSFDRPNIRYTLEEKYKPMEQLTRFVLAQKGKSGIIYCNSRNKVERIAESLRNKGVSAAAYHAGMETAIRERVQQDFQRDNVQVVVATIAFGMGINKSNVRFVAHFDLPRSIESYYQETGRAGRDDLPAEAVLFYEPADYAWLQKILLEKPETPQRQIEQHKLEAIGEFAESQTCRRLVLLNYFGEHRQTPCNNCDICLDPPKKYDGLVDAQKVMSTIYRVGQCFGAHYVIAVLRGMHNQKIIERQHHKLSVYGIGKDKSKEHWQSVIRQLIHLGFVQQVISELNPTLQLTESAKVILKGEEPLELAMPRISAISKIAHNPQRQGVANYDKDLFARLRFLRKQIADKENIPPYIVFNDATLQEMAQYMPTSNIEMLQINGVGSIKLERFGQPFMALIQEHKAILANAQNND
What is the function of this protein?
DNA helicase.
What are the official names of this protein?
ATP-dependent DNA helicase RecQ.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
Protein: TRIB3_BOVIN
Sequence: MRASPLAVPANAPSRKKRLELDDDLDTECPSQKQARSGPQPRLPSCPLTLNPPPAPVHAPDVTTPSRLGPYVLLEPEEGSRTYRALHCPTGTEYICKVYPACERLAVLEPYWRLPHHGHVARPAEVLAGTQLLYAFFLRPHGDMHSLVRRRRRLPEPEAAALFRQMAAALAHCHQHGLVLRDLKLRRFVFTDRERTKLVLENLEDACVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPALLFGKIRRGAFALPEGLSAPARCLVRCLLRREPTERLTASGILLHPWLRENAIPAALPRSRHCEADQVVPEGPGLEEAEEEGERDMGLYG
What is the function of this protein?
Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (By similarity).  Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress.  May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity).  Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity.  Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation.  May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity).  Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity.  Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity).  Can inhibit APOBEC3A editing of nuclear DNA (By similarity).
What are the official names of this protein?
Tribbles homolog 3, TRB-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: BRD7_CHICK
Sequence: MGKKHKKHKSDKHPYEEYVEKPLKLVLKVGGNEVAELSTGSAGLDSSLYEDKSEHEKHKDRKRKKRKKGEKQVPGEEKEKRKRKVKEDKRKRDREHPDSEGEQELRCQTPIRLELSPEKPLTSSLSKQEEVEQTPLQEALNQLMRQLQRKDPSSFFSFPVTDFIAPGYSMIIKNPMDFSTMKEKIKNNGYQSIEELKDNFKLMCTNAMTYNKPDTIYYKAAKKLLHSGMKILSQERIQSLKQSIEFMADLQKTRKQKDKVELQLSGEDESGSGKDKGEPVDGDTKAFKTPNKEHKKKDKDLLEDKLRINSLEREQEQIDRIVRESGGKLTRRLANSQCEFERRKPDGTTTLGLLNPVDLTAGEAGYCPVKLGMTAGRLQSGVNMLQGFKEDKRNKVTPVTYLNYGPYSSYAPTYDSTFANISKEDSDLIYSTYGEDSNQGSFSIHEFLMKSQDYPFLMADSLLDVLTKGGHSRSLRELETPLEEDEGPHERSDALKEIMEIDIAARLDSANNDRLTALKAVTNFGMPMEEFDSEEAEIFQRKLDETTKLLRELQDAQNERLSTKPPPNMICLLGPSYREMHLAERVTNNLKELAQQVTPGDIVSTYGIRKAMGISIPLPDIGDSGVDLTDEFQEPKKTVTITENECGPVTV
What is the function of this protein?
Acts both as coactivator and as corepressor.  May play a role in chromatin remodeling.  Participates in the Wnt signaling pathway.  Transcriptional corepressor that down-regulates the expression of target genes.  Binds to target promoters, leading to increased histone H3 acetylation.  Coactivator for TP53-mediated activation of transcription of a set of target genes.  Required for TP53-mediated cell-cycle arrest in response to oncogene activation.  Inhibits cell cycle progression from G1 to S phase (By similarity).
What are the official names of this protein?
Bromodomain-containing protein 7.
What are the subcellular locations of this protein?
Nucleus.
Protein: CCSA_GOSHI
Sequence: MIFSTLEHILTHISFSVVSIVITIHFLTLFLLVDEVVGLYDSSEKGMIVTFFCITGLLVTRWIYSGHFPLSDLYESLIFLSWGFSLIHMVSYLKFKKRKNNLSAITAPSAIFTQGFATSGLLTKMHQSAILAPALQSQWLMMHVSMMVLGYAALLCGSLLSVALLVITFRKAIKIIGENNNFSFSFGKIQYMNERSNVLLNTYFLSSKNYYRYQLTQQLDRWSYRIISLGFIFLTIGILSGAVWANEAWGSYWNWDPKETWAFITWTVFAIYFHTRTNTNLEGVNSALVASMGFLIIWICYFGVNLLGIGLHSYGSFTLN
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GCS2_POLSJ
Sequence: MSLEVFHKSAALSLGVELELQLVNTHDYDLAPYAEDMLRLMHKIPLPGSVVPEMTSSMIEISTGVCSSSSEVLGQLSQIRDALVKSADKLNIAVVGGGTHPFQQWHERRIYDKPRFRELSELYGYLSKQFTIFGQHVHVGCPNADSALLTLHRMSRYIPHFIALSASSPYVQGQDTAFDSARLNSVFAFPLSGRAPFALTWDDFKVYFDKMTRTGVVKSMKDFYWDIRPKPEFGTIEIRVFDTPLTVERATALAGFVQSLASWFMNEQPFMPTEDDYLVYTYNRFQACRFGLDAVYVDPATGGHMPLREHILMTMERIARHAGAVGAGASLHLLQTSVERSDNDARWLREKQGEERLLAEVIRQAAQRFRGGVTHTQLP
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: RLME_WIGBR
Sequence: MKNMCSNWWLSEHYSDKFVKESKKCKYRSRAWFKIDEIQKKNNIIKPGMVVLDIGSSPGGWSKYSSQKVGMSGKVIACDIDLMNPIPNVSFILGNIFEKITIKKIKKVKKKVHIILCDISPNITGLSIIDHSRWISLNNNILNICKYLLLKNGKLIIKSFNSVEIKNFCKKIENSFKKIKIFKPISSRSRSKEIYIVAVNYKL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_STAAE
Sequence: MKKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGRVKTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAIENIDIGGPTMLRAAAKNYKHVTTIVHPADYQEVLTLLRNDSLDESYRQSLMIKVFEHTAEYDEAIVRFFKGDKETLRYGENPQQSAYFVRTSNAKHTIAGAKQLHGKQLSYNNIKDADATLALVKKFDTPATVAVKHMNPCGVGIGDTIEQAFQHAYEADSQSIFGGIVALNRAVTPELAEQLHSIFLEVIIAPKFTDEALDILKQKKNVRLLEIDMTIDSNEEEFVSVSGGYLVQDKDNYVVPKEEMKVVTEVAPTDEQWEAMLLGWKVVPSVKSNAIILSNNKQTVGIGAGQMNRVGAAKIALERAIEINDHVALVSDGFFPMGDTVELAAQHGIKAIIQPGGSIKDQDSIDMANKHGIAMVVTGTRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: GCH1_STRPY
Sequence: MKRERLMSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFAGLKKDPKEEFTAVFTEHHEDVVIVKDISFYSMCEHHQVPFYGKAHIAYLPSDGRVTGLSKLARAVEVASKRPQLQERLTAQIADALVEALHPTGVLVLVEAEHMCMTMRGIKKPGSKTITTTARGLYKEDRSERQEVMALMTKV
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: COX1_STRPU
Sequence: MQLSRWLFSTNHKDIGTLYLIFGAWAGMVGTAMSVIIRAELAQPGSLLNDDQIYNVVVTAHALVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLIPPSFILLLASAGVENGAGTGWTIYPPLSSNITHAGSSVDLAIFSLHLAGASSILGLINFITTIINMRTPGMSLDRLPLFVWSVFVTAFLLLLSLPVLAGAITMLLTDRNINTTFFDPAGGGDPILFQHLFWLFGHPEVYILILPGFGMISHVIAHYSGKREPFGYLGLVYAMIAIGVLGFLVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGLKVFSWMAKLQGSNLQWSLPLLWTLGIVFLFTLGGLTGIVLANSSIDFVLHDTYYVVAHFHYVLSMGAVFAIFAGFTHWFPLFSGYSLHPLWGKVHFFIMFVGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTISSIGSTISVVAMLFFLFLIWEAFASQREGITPEFSHASLEWQYTSFPPSHHTFDETPSTIIIVK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.