PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_WIGBR
Sequence: MFKKNINIKIKTKILNLRKKIEMWNNNYYVKNLSLVSDEKYDSTLFELNELEKKYSMFLNTSYSNKIVAKNICNKFKKIKHLSNMLSLESIFNYKNLLNFHEKVKKNLFYNEKRYYCCELKIDGLAINLIYKNGILDSASTRGDGLQGEDVTKNALEIKSIPHILKKNNLSFPKKIEIRGEVFIKLSTFNKINKMLKSKRKKLFSNARNMASGSLRQINPKITKNRSLSFYGYGIGYVNEKKYYYDQHDALKLINSWGIPIEKNTELCKSLNEVKNFYEKSIKIRDYLDFNIDGIVVKVNSMKLQKKLGCSSKYPRWAIAYKFSSEEKCTKILGVNFNVGRTGVITPVAKLKPVYFMGTIIKYSSLHNKDIIDKLGIMINDTVCLKKSGDVIPKISRVIFEKRKNVKEIIFPKTCIFCKSKIEFCLRKKNLYCTGGFLCYAQRKQLLNHFVSREALNIKGMGNKIISQLIEKKIIKYPSDIFKLNTDKIIFLKGMGLKSSENLIKEIIKSKTTELYRVIYGIGIPNVGIYTSMNLANYYKNISNFINTSYEDLRSIKGIGSFTSNCIKKFLKDKRNISIISDLLNVNLKIK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL29_ACTSZ
Sequence: MKAQELRNKNVEELNAELNNLLGEQFKLRMQAATGQLQQTHQLKQVRRNIARVKTVLNQKAGE
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: PTPRE_MOUSE
Sequence: MEPFCPLLLASFSLSLARAGQGNDTTPTESNWTSTTAGPPDPGASQPLLTWLLLPLLLLLFLLAAYFFRFRKQRKAVVSSNDKKMPNGILEEQEQQRVMLLSRSPSGPKKFFPIPVEHLEEEIRVRSADDCKRFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHCRVILSQVDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQRSATIVMLTNLKERKEEKCYQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIHPQLPDSCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPSHAGPIVVHCSAGVGRTGTFIVIDAMMDMIHSEQKVDVFEFVSRIRNQRPQMVQTDVQYTFIYQALLEYYLYGDTELDVSSLERHLQTLHSTATHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEFTDYINASFIDGYRQKDYFMATQGPLAHTVEDFWRMVWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGDITIEIKSDTLSEAISVRDFLVTFKQPLARQEEQVRMVRQFHFHGWPEVGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
What is the function of this protein?
Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase epsilon, Protein-tyrosine phosphatase epsilon, R-PTP-epsilon.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin can induce translocation to the membrane. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Protein: SYH_STRU0
Sequence: MKLQKPKGTQDILPGEAAKWQYLENVARETFKKYHYGEIRTPMFEHYEVISRSVGDTTDIVTKEMYDFHDKGDRHITLRPEGTAPVVRSFVENKLFAPEVQKPVKLYYIGSMFRYERPQAGRLREFHQIGVECFGSANPASDVETIAMASHLFETLGIKDMTLHLNSLGNPSSRAAYRQALIDYLTPMREQLSKDSQRRLDENPLRVLDSKEVEDKVAVENAPSILDYLDEESKAHFEAVQEMLTTLNIPFVIDTNMVRGLDYYNHTIFEFMAKVEGSDLTICAGGRYDGLVSYFDGPETPGFGFGLGLERLLLILEKQGITLPIEEPMDVYLAVLGEAANSKALALVQAIRKQGFTAERDYLGRKIKAQFKSADSFNAKTIITLGESEVETGKVIIKNNQTREEMEVSLEEITSNFATIMEKLV
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA1_LEGPH
Sequence: MNWSNTPSFLEKQRQRLERYQFQIKVSEQGRVVSVGDGIIWIKGLPGAAIDEILISEDECCIAMVFHLTEELVGAVMLVQTKKLKAGTPIFPLKRVLSIPVGDKLLGRVIDPLGHPLDGGEIPPHEEQGLLDRLSPPILHRDFVNRPLYTGNKMLDNLIPIGKGQRELLIGDNGLGKSALALDIVMNQKDKKVYCVYVLIGQKRSTVSSTIQLLKEANALDYTTVVVAQATALPGLLYLAPFAGCAIAEHWMKKGLDALVIYDDLSAHANSYRELSLLLRRPPGREAFPADIFYLHSRLLERSTCLSPALGGGSMTALPIIETKEGEMATYIPTNLISITDGQIFFDESLFSSGFLPAIDITKSVSRVGGKAQHPQIKKESGRMKLDYLQFLDLELFTRFGAKLDAKMQKQIQKGRVLREILKQERFSPLPIEFQLAWLIAYNEGFFDELNLEDIPKMLKKIEEEIKQSTLSLGSPREQWKKAIKEWLMA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 1, ATP synthase F1 sector subunit alpha 1, F-ATPase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HUTU_MOUSE
Sequence: MSSLQELCSGLPLRPLPENRGRWAGVPHAPVRTPNLSPEEEQLALRNALRYFPPDVQKLLALEFAQELRQFGHIYMYRFCPSIEMRAYPIDQYPCRTRAAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFRLTMSYLSKMTEEQTLVMYSGHPLGLFPSSPRAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGRRYLGIENLAGKVFVTSGLGGMSGAQAKAAAIVGCIGVIAEVDKAALVKRHRQGWLMEVTDSLDRCIARLREARKKKEVLSLGYHGNVVDLWERLVHELDTTGELLVDLGSDQTSCHNPFNGGYYPVQLSFSEAQSLMSSNPAAFKHLVQESLRRHVAAINRLAQEKFFFWDYGNAFLLEAQRAGADVEKKGANKMEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDHLATSVLEKAIADGVKASVKLQYMDNIRWIREAAKHQLVVGSQARILYSDQKGRVAIAVAINQAIASGKIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTAEAEQKARMMLSWDVSNGVARRCWSGNPKAYEIICQTMQENSGLVVTLPHEVADEQVLQQALRP
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
Protein: CENPS_ARATH
Sequence: MFNISYAKRNAKYLFKLLAWCMMIEEAGPNIGNKQKVVLQLSKMLIMYIILHINAAFWTWRGYLKRCVLHFVFPRIFLPLLSDSPTITQAKKPSYCFAMDVGGEDISDLQVDQIVEEYSMDDLIRDRFRLSAISIAEAEAKKNGMEIGGPVVACVADLAFKYAENVAKDLELFAHHAGRKVVNMDDVVLSAHRNDNLAASLRSLCNELKAKEPQSERKRKKGSAKKEDKASSSNAVRITTDL
What is the function of this protein?
Involved in the promotion of spontaneous somatic homologous recombination (HR) events, which is opposite to the function of FANCM in ordered HR.  Only FANCM is essential for replicative repair in the absence of the endonuclease MUS81 (PubMed:24635147).  Acts in the same pathway as FANCM to restrain class II meiotic crossing over (CO), and acts with FANCM during meiosis to repair interstrand cross-links (ICLs) (PubMed:24635147, PubMed:25038251).  This common pathway between MHF1 and FANCM is in parallel to the pathway that involves the RECQ4A helicase (PubMed:24635147).
What are the official names of this protein?
Protein MHF1 homolog, AtMHF1.
What is the protein family that this protein belongs to?
Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: REV_HV190
Sequence: MAGRSGASDTELLQVCKIIKILYQSNPCPEPTGTRQARRNRRRRWRARQRQIREISERILTSCLGRPPEPVTLQLPPLERLTLNCSEDCGTSGEKGEGSPQISLESSTILGTGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: LEMD2_MOUSE
Sequence: MAGLSDLELRRELQALGFQPGPITDTTRNVYRNKLRRLRGEARLRDDERLREDAGPREDAGPRGPERQREEARLREEAPLRARPAASVLRSEPWPLSPSPPAPSAASDASGPYGNFGASASPWAASRGLSYPPHAGPGPLRRRASVRGSSEDDEDTRTPDRHAPGRGRHWWAPPSASARPHSALLGADARPGLKGSRTGSAGAGRTRPEVGRWLERCLSRLLLWASLGLLLGFLAILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVLEAQEYIANVTSSPSSRFKAALTWILSSNKDVGIWLKGEDPSELATTVDKVVCLESARPRMGIGCRLSRALLTAVTHVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER
What is the function of this protein?
Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization and maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967).  Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (By similarity).  Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (By similarity).  During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (By similarity).  Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (PubMed:36377660).  Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT (PubMed:25790465).  Required for myoblast differentiation involving regulation of ERK signaling (PubMed:17062158, PubMed:19720741).  Essential for cardiac homeostasis and proper heart function (PubMed:36377660).
What are the official names of this protein?
LEM domain-containing protein 2, Nuclear envelope transmembrane protein 25, NET25.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein. Nucleus envelope. Cytoplasm, cytoskeleton, spindle. Note=Lamina-associated protein residing in the inner nuclear membrane (INM) of the nuclear envelope (NE) (PubMed:16339967). The localization to the INM is dependent on LMNA (By similarity). Evenly distributed around the NE during interphase (PubMed:16339967). During metaphase, found in a reticular network (By similarity). Recruited to the reforming NE on chromatin disks in early anaphase (By similarity). In late anaphase, concentrates at the NE core proximal to spindle microtubules, and then broadening to a distributed nuclear rim pattern (By similarity).
Protein: UNC4_HUMAN
Sequence: MMDGRLLEHPHAQFGGSLGGVVGFPYPLGHHHVYELAGHQLQSAAAAASVPFSIDGLLGGSCAAAASVVNPTPLLPAACGVGGDGQPFKLSDSGDPDKESPGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIARKELEKMEKKKRKHEKKLLKSQGRHLHSPGGLSLHSAPSSDSDSGGGGLSPEPPEPPPPAAKGPGAHASGAAGTAPAPPGEPPAPGTCDPAFYPSQRSGAGPQPRPGRPADKDAASCGPGAAVAAVERGAAGLPKASPFSVESLLSDSPPRRKAASNAAAAAAAGLDFAPGLPCAPRTLIGKGHFLLYPITQPLGFLVPQAALKGGAGLEPAPKDAPPAPAVPPAPPAQASFGAFSGPGGAPDSAFARRSPDAVASPGAPAPAPAPFRDLASAAATEGGGGDCADAGTAGPAPPPPAPSPRPGPRPPSPAEEPATCGVPEPGAAAGPSPPEGEELDMD
What is the function of this protein?
Transcription factor involved in somitogenesis and neurogenesis.  Required for the maintenance and differentiation of particular elements of the axial skeleton.  May act upstream of PAX9.  Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).
What are the official names of this protein?
Homeobox protein unc-4 homolog, Homeobox protein Uncx4.1.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Unc-4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: G3PC2_HORVU
Sequence: VNDPFITTDYMTYMFKYDTVHGQWKHHEVKVKDSKTLLFGEKEVAVFGCRNPEEIPWAAAGAEYVVESTGVFTDKDKAAAHIKGGAKKVIISAPSKDAPMFVCGVNEKEYKSDIDIVSNASCTTNCPAPLAKVINDRFGIVEGLMTTVHAMTATQKTVDGPSSKDWRGGRAASFNIIPSSTGAAKAVGKVLPELNGKLTGMAFRVPTVDVSVVDLTVRLAKPATYEQIKAAIKEESEGNLKGILGYVDEDLVSTDFQGDSRSSIFDAKAGIALNDNFVKLVSWYDNEWGYSTRVVDLIRHMHSTK
What is the function of this protein?
Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.  Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_RALSO
Sequence: MQHAPLNFVPDAAKVPPTPGQSPNARWSREAIEALFALPFNDLLFQAQQVHRAHFDANAVQLSTLLSIKTGGCPEDCSYCPQSARYDTGVEAEKLMPIDTVLEAAARAKQNGASRFCMGAAWRNPKPHQLDAVADMVRGVKAMGLETCVTLGMLKQEQAQQLKDAGLDYYNHNLDTAPEFYGEIITTRTYQDRLDTLEHVRDAGINVCCGGIVGLGESRHERAGLVAELANMEPYPDSVPINNLVKVEGTPLAGNEALDPFEFVRTIAVARITMPKAMVRLSAGREAMDDALQALCFMAGANSIFYGEKLLTTDNPEADADRKLLARLGMRVEVQDHLHQAEGAQHSHSSHCHIDITPAD
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: Y7503_DICDI
Sequence: MADDNKDNDNEIIFTPKNIKHCEEKSNKFFNVLLANKNNFNKKECKDAFEDLSQCCEASNNLPDPVDKIHPAVKLLQHCLPRLFTNDLPRERTIIADTLAYLMPKVFDPEDDDEDD
What are the official names of this protein?
Putative uncharacterized protein DDB_G0287517.
Protein: RS9_MOUSE
Sequence: MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEEED
What is the function of this protein?
Component of the small ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
What are the official names of this protein?
40S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: BLI_ARATH
Sequence: MASATSSRRQEDVEAGRRKLEQFRKRKAAEKAKKASQNTQPVDNSQQSVIDSDGAGASISNGPLKQSAESTSNETHTKDVYNLSFSNTAMDDGSKERSRQDDGQESVGKVDFSNSLELIGSSKDLTVNTRPEVVPYSNIDKQSSESFDRASTLRETASLFSGTSMQMDGFIHGSGLTSSRKDSLQPTTRMAGSFDEVAKNQQGSGELGGSIVQKPTLSSSYLFNSPDTSSRPSEPSDFSVNITSSSPLNSAKSEATVKRSRPSFLDSLNISRAPETQYQHPEIQADLVTSSGSQLSGSDGFGPSYISGRRDSNGPSSLTSGASDYPNPFEKFRSSLYPAANGVMPGFTDFSMPKQNDDFTALEQHIEDLTQEKFSLQRDLDASRALAESLASENSSMTDTYNQQRGLVNQLKDDMERLYQQIQAQMGELESVRVEYANAQLECNAADERSQILASEVISLEDKALRLRSNELKLERELEKAQTEMLSYKKKLQSLEKDRQDLQSTIKALQEEKKVLQTMVQKASSGGKSTDLSKNSTSRKNVSTSTEGLAISDTTPESSNQETDSTTLLESDSSNTAIIPETRQLTLEGFSLSVPADQMRVIHNINTLIAELAIEKEELVQALSSELSRSAHVQELNKELSRKLEAQTQRLELVTAQKMAIDNVSPEKQQPDTHVVQERTPIADEGDEVVERVLGWIMKMFPGGPSKRRTSKLL
What is the function of this protein?
Is required for normal leaf, flower and seed development and controls cotyledon and leaf patterning by inhibiting premature differentiation.  Regulates the expression of a subset of PcG target genes.  Is required for the repression of the floral specific genes PI, SEP2, and SEP3, but also for the activation of FLC (PubMed:20647345).  Involved in response to cold.  Involved in the regulation of COR15A, COR15B, BAM3 and AMY3 transcripts, and ascorbate levels in response to prolonged chilling temperatures (PubMed:20674078).
What are the official names of this protein?
Protein BLISTER, Protein KOLD SENSITIV-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=May shuttle between the nucleus and the cytoplasm.
Protein: BAMA_ECODH
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFEDVRVLRDGDTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTIADIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAEIQQINIVGNHAFTTDELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYVTVNITEGDQYKLSGVEVSGNLAGHSAEIEQLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSMPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDAVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYAVGINGTKNDYQTYAELSVTNPYFTVDGVSLGGRLFYNDFQADDADLSDYTNKSYGTDVTLGFPINEYNSLRAGLGYVHNSLSNMQPQVAMWRYLYSMGEHPSTSDQDNSFKTDDFTFNYGWTYNKLDRGYFPTDGSRVNLTGKVTIPGSDNEYYKVTLDTATYVPIDDDHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYFPHQASNYDPDYDYECATQDGAKDLCKSDDAVGGNAMAVASLEFITPTPFISDKYANSVRTSFFWDMGTVWDTNWDSSQYSGYPDYSDPSNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: CYCM_RICBR
Sequence: MSGKELNKIVAAILFASLIAMMVGFIANILYKPVLEPKHRGYSIAVQEVSEAPTTQAQAPINIPELMKTANADNGREIAKKCLMCHSLDKDGPNKIGPHLWDVAGRPKASITDYKYSPALSALGGNWDDDSLFAFLHKPSSYAPGTKMSFAGISKPQDIADVILFLKTYVHDK
What is the function of this protein?
May be involved in electron transfer from bc1 complex to aa3.
What are the official names of this protein?
Cytochrome c homolog.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: CHEB_CHAGB
Sequence: MGSFEIPEKHTALLQGEGGSLVIARDVPLPTLGPGHLLVKTAAVALNPCDFKTPAAFPNPGYYNGCDFAGTVVALGSDNIRDGGPWKIGDRIFGAIHGANPSDWDSGSHAEYVKAVSVFSYRIPDWMTFEEAAGLSPCCIATMGVSLFKALELPGTFEEPATKPLDVLIYGGSSSVGSLGIQMVKLTGHRLGHRCITTCSPKNFDLVKSYGADEVFDYKSPTCAQDIRKATRNCLKYAVDPFGEVKTMAICTEAIGRAGGRYSALEKFQEDVCDRKTVKRELTMGAIIIGHGLDLGGRYTRPHSPEMRAWGIEWYKSIQRLVDARKFKPHPIRVLKGGFEDMLEGLAMLKRREISAEKLVVSLDPAVSGLTADSTAR
What is the function of this protein?
Enoyl reductase; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317, PubMed:33622536).  Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C. globosum (PubMed:33622536).  The first step of the pathway is the synthesis of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase cheA, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase cheB (PubMed:23611317).  Further multiple oxidation steps performed by the cytochrome P450 monooxygenases cheE and cheG, as well as by the FAD-linked oxidoreductase cheF, lead to the formation of chaetoglobosin A (PubMed:23611317).  Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317).  Within the pathway, the cytochrome P450 monooxygenase cheE catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317).  The FAD-linked oxidoreductase cheF performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317).  Finally, the cytochrome P450 monooxygenase cheG can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317).  The Diels-Alderase cheD may play a role in the post-PKS-NRPS biosynthetic steps catalyzing Diels-Alder cyclization (Probable).
What are the official names of this protein?
Enoyl reductase cheB, Chaetoglobosin A biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: ENO_META3
Sequence: MDNSFDILDIKAREVIDSRGNPTVEVEVLTAGGYGSAIVPSGASTGTHEAVELRDKSQRFGGKGVLVAVDNVNSIIAPELIGFDSRTQREIDTYMIELDRTANKGKLGANAILAVSMAVAKAAASTASLPLYKYIGGCNSYIMPVPMMNVINGGEHAGNALEFQEFMIMPVGADSISEAIRMCAETYHTLKKVIVSKYGKNASNVGDEGGFAPPVSDIRETLDLLTDAVKMAGYEDEITFALDCAASEFYNKDDNKYIVKGAPLSSDQLISLYKEICDEYPVISIEDPLDEEDFEGFASLTKELKGVQIVGDDLFVTNTERLKKGIEMGAGNALLLKVNQIGTLSESIDAANLAFRNGYGVVVSHRSGESEDNTIADISVALNAGQIKTGAPARGERTAKYNQLIRIEEEIGYPKYAGKNIRCPF
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SUPT3_HUMAN
Sequence: MNNTAASPMSTATSSSGRSTGKSISFATELQSMMYSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDEDDLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRIGPLSPFTNAYRRNGMAFLAC
What is the function of this protein?
Probable transcriptional activator.
What are the official names of this protein?
Transcription initiation protein SPT3 homolog, SPT3-like protein.
What is the protein family that this protein belongs to?
Belongs to the SPT3 family.
What are the subcellular locations of this protein?
Nucleus.