PharMolix/UniProtQA huggingface dataset:
Protein: MTND_XANAC
Sequence: MSRLRIFADTNPATPEFDSRDGDAIAAELVKIGVTFERWHASAPVEPGATPEQVMDAYRADIDRISAERGFKTVDVVSIAPDNPKREEMRAKFLDEHFHKEDEVRFFVAGSGLFTLHVDAKVYEIECVKDDLIAVPDGTLHWFDMGPEPHFVAIRFFTEPDGWVGHFTGTEIAKQFPRYAPKKPHKAS
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: GCH1_MYCBT
Sequence: MSQLDSRSASARIRVFDQQRAEAAVRELLYAIGEDPDRDGLVATPSRVARSYREMFAGLYTDPDSVLNTMFDEDHDELVLVKEIPMYSTCEHHLVAFHGVAHVGYIPGDDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALMKKLDPRGVIVVIEAEHLCMAMRGVRKPGSVTTTSAVRGLFKTNAASRAEALDLILRK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: RIBB_BUCBP
Sequence: MTQNLLDQFGTPKTRVKNAISALRYGHGIIVLDNEDRENEGDLIFSGETMTTEQMALTIRYGSGIVCLCITESKRKQLKLPMMVQNNTSKFGTNFTVTIEAAEGISTGVSAKDRLTTIRAAINDNAKPSDLNRPGHIFPLQAHKNGILGRIGHTEAAIEFVTLAGFKPAGIICELTNRNGTMSKVPDIIKFSKLKKMTIVTIRDLIQYISR
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: HPF_SALTY
Sequence: MQLNITGHNVEITEALREFVTTKFAKLEQYFERINQVYVVLKVEKVTHISDATLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTRHKDKLKQH
What is the function of this protein?
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
What are the official names of this protein?
Ribosome hibernation promoting factor, HPF, Hibernation factor HPF.
What is the protein family that this protein belongs to?
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Protein: RSMA_STAAC
Sequence: MLDNKDIATPSRTRALLDKYGFNFKKSLGQNFLIDVNIINNIIDASDIDAQTGVIEIGPGMGSLTEQLARHAKRVLAFEIDQRLIPVLNDTLSPYDNVTVINEDILKANIKEAVENHLQDCEKIMVVANLPYYITTPILLNLMQQDIPIDGYVVMMQKEVGERLNAEVGSKAYGSLSIVVQYYTETSKVLTVPKSVFMPPPNVDSIVVKLMQRTEPLVTVDNEEAFFKLAKAAFAQRRKTINNNYQNYFKDGKQHKEVILQWLEQAGIDPRRRGETLSIQDFAKLYEEKKKFPQLEN
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBZ_CUCSA
Sequence: MTIAFQLAVFALIVTSSILLISVPVVFASPDGWSGNKNVVFSGTSLWIGLVFLVGILNSLIS
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: RF3_STRM5
Sequence: MSEVANEASRRRTFAIISHPDAGKTTLTEKLLLFGGAIQMAGSVKGRKAARHATSDWMALEKERGISVTSSVMQFPYEGKIVNLLDTPGHADFGEDTYRVLTAVDSALMVIDVAKGVEERTIKLMEVCRLRDTPIMTFINKLDREGKDPIELLDEVETVLGIQCAPVTWPIGMGQRLKGVVHLLTGEVHLYEPGRNFTRQDSTIFPSIDAPGLAEKIGAQMLAELRDELDLVQGASHPFDLDAYRAGKQTPVFFGSGVNNFGVQPLLDFFVEHAPPPQARTTTGRVIAPEENKLTGFVFKIQANMDPQHRDRVAFMRICSGRFSAGMKTFHVRTGKDMKLANALTFMASDREIAAEAWPGDVIGIHNHGTISIGDTFTEGEAVTFTGIPNFAPELFRRARLRDPLKLKQLQKGLAQLSEEGATQFFRPLTSNDLILGAVGVLQFDVAAYRLKDEYGVEATFEQVSVSTARWVHCSNEKKLEEFREKNALNLALDAAGHLVYLAPTRVNLQLAQERSPDVRFSATREAAHTVSVG
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT76_CYRHA
Sequence: DPSGSPHIRILPQETFEDICRLPSDSGDCLRFFEMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Dual-function toxin that inhibits both serine proteases and voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type serine protease inhibitor HNTX-0109076.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 03 (sub-Kunitz) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RIMM_XYLFT
Sequence: MKDNERRILLGRVVGGFGLRGEIKIESWTEPRDAIFRYQPWLLRSPTGTESMLNGARGYETGKRLIATFPGINDRNGVEAICGTEIYVPRSALPPPHPDEYYWVDLEGLQVHTLEGVVLGSVSHLFSNGANDVIVIHGERERLIPFVQPDYVKSVDFEAERIVVDWDPEF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RJ1_HHV6U
Sequence: MARVMTRGMARVSTLATVRVSTLARARFSVRDSFMVSVIVGVRVRVDVLVRVNVLVRARPRVRVRARPRVRVRVRARPRVRVRVRASPRVRVRVITPPFFSPPGGFDVIFKTRGIPSPGETVLDKKVSRPWRGLTSRRGATMI
What are the official names of this protein?
Protein RJ1, Protein LT1.
Protein: ROA1_PANTR
Sequence: MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
What is the function of this protein?
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection.  Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.  Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1.  May bind to specific miRNA hairpins.
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand-binding protein, hnRNP core protein A1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes.
Protein: NHAB_SHIDS
Sequence: MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMTSAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRHQRTRQDKIRLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLSSISDNVFVGTIYINEAKAAMESGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PANC_ECOLI
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIITIAGQELNEKGFRADDIQIRDADTLLEVSETSKRAVILVAAWLGDARLIDNKMVELA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMS2_CAEEL
Sequence: MTNSSEFTDVLQSRDPCVSNGIVINIDPIDPEPTPIRKEFTCEDTFHHEHHGNSEGFKTLTAFLCLMLSAFLNFFLLTVIHDVVPRQPLPDLTFMIIPQQRWAWSVGDVLSTVSSVVAFTIIFLHHQRWIVLRRTFLLGAIMYGLRAVILGVTFLPPSFHNRDEICQPQVNRTAMYGMEIATRFLTYVITLGLTSGQDKILCGDLMFSGHTVVLTIMYFVQLQYTPRGLVILRYIAAPITFLGIAALVVSGGHYTMDVLIAYWLTSHVFWSYHQIFEMRKDDRPQAPLSRLWWFWLCYWFESDVADGKLVNKWNWPLEGPQRMHTIMNRINYKLQ
What is the function of this protein?
Sphingomyelin synthases (SM synthase or SMS) synthesize the sphingolipid sphingomyelin (SM) through transfer of the phosphatidyl head group of 1,2-diacyl-sn-glycero-3-phosphocholine (phosphatidylcholine, PC) on to the primary hydroxyl of ceramide (N-acylsphingoid base), yielding 1,2-diacyl-sn-glycerol (diacylglycerol, DAG) as a side product.  Functions as a bidirectional lipid cholinephosphotransferases capable of converting PC and ceramide to SM and DAG and vice versa depending on the respective levels of ceramide and DAG as phosphocholine acceptors, respectively.
What are the official names of this protein?
Phosphatidylcholine:ceramide cholinephosphotransferase 2, PC:ceramide cholinephosphotransferase 2, Sphingomyelin synthase 2, CSS3alpha2, SMS-2.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelin synthase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RGI2_YEAS2
Sequence: MTKKDKKAKGPKMSTITTKSGESLKVFEDLHDFETYLKGETEDQEFDHVHCQLKYYPPFVLHDAHDDPEKIKETANSHSKKFVRHLHQHVEKHLLKDIKTAINKPELKFHDKKKQESFDRIVWNYGEETELNAKKFKVSVEVVCKHDGAMVDVDYKTEPLQPLI
What is the function of this protein?
Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
What are the official names of this protein?
Respiratory growth induced protein 2.
What is the protein family that this protein belongs to?
Belongs to the RGI1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPG_METTH
Sequence: MVVILIIDNYDSFTHNLYQLAGEILRDEGMDEEIMVLRNDEARISDLRALDPEKIIISPGPGNPSRRSDFGVCMDVIGEFTDRPLLGVCLGHQGIFHAFGGRVDQGEPVHGKIVEVFHDGSELFRDVPNPFRATRYHSLVCRPEDTPADIEVTAVTSDEIIMAIKHREYPVYGLQFHPESAGTPSGRTVIRNFLRM
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 2, AS, ASII, Anthranilate synthase, GATase component, Anthranilate synthase, glutamine amidotransferase component.
Protein: NUDI_SHISS
Sequence: MRQRTIVCPLIQNDGAYLLCKMADDRGVFPGQWALSGGGVESGERIEEALRREIREELGEQLLLTEITPWTFSDDIRTKTYADGRKEEIYMIYLIFDCVSANREVKINEEFQDYAWVKPEDLVHYDLNVATRKTLRLKGLL
What is the function of this protein?
Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
What are the official names of this protein?
Nucleoside triphosphatase NudI, Nucleotide diphosphatase NudI, Pyrimidine deoxynucleoside triphosphate diphosphatase, dCTP diphosphatase, dTTP diphosphatase, dUTP diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudI subfamily.
Protein: Y304_TREPA
Sequence: MAPAAIPLPSEETTPPVIKIKAGSIRHECSVSMRFLKGSTLPLPCACRVDCPIGLHRTLLSNTMGPMNARAALALAMVFTFQRLCAEERFVISTEYFDIIYTEASTESARILAKHADRYEEQISLMLNRVPDKKKRTTVVLYAHTQDAGGSFSSKPSRKIIINDTRVPNLGLGSFKDSLLSIFYHELTHKISLDFFMPLLPPLFTEGVAVAFESNDGTQGRLHDPLTMHYLIQNKLENVSPSWREVAELRYNYPHGMPYVYGGKFTEYLQKIYGKERCARLWQNSWRLFIRHRFWDVFQKNLGTAWNEFIDSIPIPEKVAQPQLLSEREAQGHYGARSAAPTGFAYYDRDRHAVRFRDKAGGVRTLFSHDNTLHHLNFSEDGRYLAVSDTIDTWSERTHRVRVFDTHSGSFSPEVYTGASEACFVGNGQKIVFVRVQGQYSRLTLKDRTDPTFEKVLYEAGPGLPFGALYAPAYAGDGTVAIIGARGMERNLLFIPVDDRPMMQVPREQMPHAMRELQSQKIKGSWTLTFSWANMNMLSRLGFYDVSRHTFRLMDQDVSGGVFAPVVYEALPAAVHEESAAEATIRGEEPVVRVAYTGRHRMHMSQYQRDDRALRERRVSLVPLHPAEAEEQSRPATLMVNGEFIADVHEADRGRRYRAAQWMWPPTFSPRFVPPNSFSSLKDLGHTGLGVNMKFADPFGLVEVNLQSVSHFYPFFTSLGLKSSFYVGKTTYALRAYHEIDTGGFRYTKLGGAFETLTNFPMQDDRNAFFVRTAVGVDSYSCLCANGGGNGNCCGNNGGQQCCACNGQGANGPHYYKSLESPFIQAQVEMGYSFSQRAERTGTNWFVADVTGVSLKLHVANSFDTGKTKDAVLVQTKGSFRLPVVPLRVGVSAYVGYNAGWRGGKGNILAEHPVYGFPGPTYLPKLAGVGGMEGSCKKSKSAGFGAEAVLTILDYDISIYDPYLPVFYRNIVWNVSCEYVLNAPDFSSPKHLCVASTSLVLEFDLADVKVRAGVQYGFQLAETQSATTPGFSPIFSMAV
What are the official names of this protein?
Uncharacterized protein TP_0304.
Protein: COXX_BACCZ
Sequence: MNHATSELHDESAVTSIPETTRLQDLKALVKMGIVNSNTLTVFTGFWLALHFNGLSVMDNLDKLFFTIVGSGLVMAGVCCLNNYIDRDIDPLMERTKTRPTVTGKYKPGFALTFGLVILLLGFVFLLLTTPMAVLMGFIGAFTYVVLYSLWTKRKYTLNTVVGSISGAVPPLIGWAAIDPSLGHPIAWMLFLIMFIWQIPHFLALAMKRVDEYRNAGIPMLPVVHGFEITKRQIMIWTVCLLPLPFYMSGLGITFMVIATLLNIGWIVLGFYGFRKKDDIKWSVQMFVYSLNYLTILFVSMIVVTFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURG_KLEP7
Sequence: MSGQEKRLMVMAGGTGGHVFPGLAVAHHLMDQGWQVRWLGTADRMEADLVPKNGIEIDFIRISGLRGKGIKAQLLAPVRIFNAWRQARAIMKRFQPDVVLGMGGYVSGPGGLAAWSLGIPVVLHEQNGIAGLTNKWLAKIAKKVMQAFPGAFPHADVVGNPVRTDVLALPLPGQRLVGRQGPIRVLVVGGSQGARVLNQTMPQVAAKLGATVTIWHQSGKGGQQTVQQAYAAAGQPQHKVTEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGAAKILEQPEFTVEAVASTLASWDRETLLDMAERARGASIPDATERVAEEVSAVALAR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL33_HAEIG
Sequence: MAAKGAREKIRLVSTAETGHFYTTDKNKRNMPEKMEIKKFDPVVRKHVIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: TIG_PARDP
Sequence: MQVKETQNEGLKRGYEFTLPAADLAAQVDAKLKEAQPEVEMKGFRKGKVPMALLKKQFGQRIMGDAMQEAIDKALRDHLEKSGDRPALQPKIEMVNGETWKEGDDVVVTVAYEALPAIPEADLSGVELERLVVEASEEQVTEALENLAKNAQSFEDRKKGTKAKDGDQIVIDFKGMVDGEAFEGGSAEDYPLVLGSKSFIPGFEEQLVGAKAGDEVKVEVKFPEDYGHPALAGKDAVFETTVKAVKAPKAAEIDDELAKKFGAESLDALKGQIRERLEAEYKGASRQVLKRTLLDRLDEMVKFDLPESLVEAEAHQIAHQLWHEEHPEEHGHNHGEIEPTDEHKKLAERRVRLGLLLAEIGQKAEITVSDQEMTQAVLRQARQFPGQERAFFEFIQQNPQAQQQLRAPIFEDKVVDHIVEGAKVSEKPVTKDELEKAIEALDQV
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ACTP_SHIB3
Sequence: MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLFANVFKKGATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGTMLGGWLGLITAVVLMILGPTIWVQILGHEKAIFPYEYPALFSISVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF6_RAT
Sequence: MAVRASFENNCEVGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDSLT
What is the function of this protein?
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm.  Behaves as a stimulatory translation initiation factor downstream insulin/growth factors.  Is also involved in ribosome biogenesis.  Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.  Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity.  In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR.  Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis.  Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC).  Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.  Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
What are the official names of this protein?
Eukaryotic translation initiation factor 6, eIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Protein: Y2604_MYCBO
Sequence: MYPCERVGLSFTETAPYLFRNTVDLAITPEQLFEVLADPQAWPRWATVITKVTWTSPEPFGAGTTRIVEMRGGIVGDEEFISWEPFTRMAFRFNECSTRAVGAFAEDYRVQAIPGGCRLTWTMAQKLAGPARPALFVFRPLLNLALRRFLRNLRRYTDARFAAAQQS
What are the official names of this protein?
Uncharacterized protein Mb2604.
Protein: RSMA_MESHJ
Sequence: MQKPVPKKHLGQNFLKDRKIAEKIVENIDLKNKEIIEIGCGTGFLTNFLLEKAKFVTCYEIDRNLIPILEKKFKNKNLRIINEDFLLAELEFKEKKTIIANLPYYITSKILFKIFANFEKFDKIILMVQNEVADRIVAKPKTPTYSKLSLASQYIAHVKKLFVVGPDSFFPKPKINSAVVFFDLRTNLDAKKTEQFFWFTKKCFQFKRKTLYNNLIFFLNKQQIEKIYNFFQFAQNIRPQQLDLVTYIRLADFYFNNIF
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBPC_HALSA
Sequence: MTVEIANIVGSGDLGVELDVEPLEADLSTPYSEYDPSNYHGLYVRLEENGPLITVYRSGKYIITGCASMESLHETNEEFLGMLADLGVTEEDTQTGFTVENVVCTAMLDELVSLNALAIGLGLEVTEYEPEQFPGLVYRPEEIGAVLLVFANGKMVITGAKDTETAESAYEYFQSKVQELV
What is the function of this protein?
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
What are the official names of this protein?
TATA-box-binding protein C, Box A-binding protein C, BAP C, TATA sequence-binding protein C, TBP C, TATA-box factor C.
What is the protein family that this protein belongs to?
Belongs to the TBP family.