PharMolix/UniProtQA huggingface dataset:
Protein: PIA2_PLEOS
Sequence: SAGKFIVIFKNGVSDDKIRETKDEVIAEGGTITNEYNMPGMKGFAGELTPQSLTKFQGLQGDLIDSIEEDGIVTTQ
What is the function of this protein?
Specifically inhibits an intracellular serine proteinase (proteinase A).
What are the official names of this protein?
Serine proteinase inhibitor IA-2, Proteinase A inhibitor 2.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I9 family.
Protein: PURL_CORAM
Sequence: MTVSNDTVDNAKATPELDQPWEELGLKQDEYDKIVGILGRRPTDAELTVYSVMWSEHCSYKSSKTHLRYFGETTTEEMASKILAGIGENAGVVDIGDGDAVTFRVESHNHPSFVEPYQGAATGVGGIVRDIMAMGARPIAVMDQLRFGPADAPDTARVLPGVVSGIGGYGNSLGLPNIGGETVFDESYAGNPLVNALCVGTLRVEDLKLAFASGTGNKVMLFGSRTGLDGIGGVSVLGSASFEEGEERKLPAVQVGDPFAEKVLIECCLELYAAGVVVGIQDLGGGGLACATSELAAAGDGGMVVNLDNVPLRAENMSAAEILASESQERMCAVVSPDNVEKFREICEKWDVTCAEIGEVTDKKDTYLVYHNGELVVDAPPSTIDEGPVYERPYARPQWQDEIQQAPEIARPESLVQAFKDMVSSPALSSRAFITEQYDRYVRGNTVKAKQSDSGVLRINEETSRGVAISADGSGRYTKLDPNMGARLALAEAYRNVAVTGARPYAVTNCLNFGSPENTDVMWQFREAVHGLADGSKELNIPVSGGNVSFYNQTGDEPILPTPVVGVLGVIDDVHKALAHDLGGIDEPETLILLGETKEEFGGSIWQQVSGGGLQGLPPQVDLANEAKLADFFVGNTSVAASHDLSEGGLAIAAFEMAQKNNVGVDLDLSVVHEDALTALFSESASRVLISTASDHLDGILQRASELGIPAVVVGTTNDSGNITFAGEEVATAELREAWSATLPNLFGHAVGANSVVE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMJ_ALCBS
Sequence: MRQSEWLDTVLGLLPGCPKGLPGFWVENEAQASGQALELVLGWHDDCLGLWRPGGKQTPLTVSFCDGKQGYRLTPERVRHERLIKALGKPKDDRIRVLDATAGLGRDAALMAQAGFQVMLAERSPILHAMLADGLQRAPASLVANMQLLACADSKIAEPSALHAVYLDPMFPAREKSAAVKKDLQWLQRLCPYPDEVEEQQLLDWARALGASRVVVKRPVKAGFLAGVTPSFSQKGKAVRFDIYTCP
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_FRATO
Sequence: MMAFLLDIITFLQISFSTNIFRINYKWVSDGYDEYKKRLSKLIPLELIELPIAKRTKTGNPKLWMEQEAKTILGKLNDSDHLVILDVNSKIISTEELADKMQNWKFNNPNVVILIGGPDGIDQSIKDIAKEKISISKMTFPHPLVRIIAEQLYRAYTILEGHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF205_ASFB7
Sequence: MVEPREQFFQDLLSAVDQQMDTVKNDIKDIMKEKTSFMVSFENFIERYDTMEKNIQDLQNKYEEMAANLMTVMTDTKIQLGAIIAQLEILMINGTPLPAKKTTIKEAMPLPSSNTNNDQTSPPASGKTSETPKKNPTNAMFFTRSEWASSKTFREKFLTPEIQAILDEQFANKTGIERLHAEGLYMWRTQFSDEQKKMVKEMMKK
What is the function of this protein?
Induces host endoplasmic reticulum stress and consequently activates autophagy and NF-kappa-B signaling pathway.  In turn, may induce autophagy-mediated STING1 degradation and innate immune evasion.
What are the official names of this protein?
Uncharacterized protein K205R, pK205R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus K205R family.
Protein: CYC2_CAMAC
Sequence: MSWWWAGAIGAARKKFEEDDAPRDCQSVALIIGVTGIVGNSLAEILPISDTPGGPWKVYGVARRPRPAWNADHPVEYIQCDISDASDTHTKLSPLTDVTHIFWVTWANRPTESECCELNGTMLRNVLNALIPKAANLHHICLQTGHKHYIGPFEAFGKIKPHEPPFTEDMPRLNAPNFYYTLEDMLVEASEKKAGLNWSVHRPAVIFGFSPFSMMNIIGTLCVYAAICKHENTPLKFPGTKAAWNCYSVASDADLIAEHQIWAAVDPYAKNEAFNCSNGDLFKWKHLWKVLAEQFGVEYAEFDESEKPTSLVERMKDKGPVWEEIVRENGLHTTKLEGVATWWFADVILGGECLLDSMNKSKEHGYLGFRNTKNSLISVIDKMKAHKIVP
What is the function of this protein?
Iridoid synthase that catalyzes the first step in generation of the iridoid ring scaffold using the linear monoterpene (6E)-8-oxogeranial as substrate.  Iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and antibacterial activities.
What are the official names of this protein?
(S)-8-oxocitronellyl enol synthase CYC2, Cyclase 2, Iridoid synthase, ISY.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. Highly divergent.
Protein: QUEC_PARD8
Sequence: MKQQDAALVCFSGGQDSTTCLFWAKKHFSRVEAVCFTYGQKHSLEIEVARKIAADADVPFQLLDVSLISQLDPNCSLTNASIEMDQEKPEDSYPNTFVPGRNMVFLTFAAILARGKGIYHLVTGVSEADYSGYPDCRDTFVRSLNVTLNLAMDEQFVIHTPLMDRDKSEVWELSDELGVFDLVRTQTLTCYNGVMAEGCGHCPACKLRKDGLEKYLKRKEENQK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: PYRB_STRA5
Sequence: MNHQTQTLSLEHFVSLEELSNQEVMSLIKRSIEVKENPSNIGFDKDYYVSNLFFENSTRTHKSFEMAELKLGLKTIEFNADTSSVNKGETLYDTILTMSALGLDVCVIRHPDIDYYKELIASPNIHSAIVNGGDGSGQHPSQSLLDLVTIYEEFGYFKGLKIAIVGDLTHSRVAKSNMQVLKRLGAEIFFSGPKEWYSSQFDEYGQYLPIDQLVDQIDVLMLLRVQHERHDGKGVFSKESYHQQFGLTKERYKHLRDTAIIMHPAPVNRDVEIASDLVEADKARIVKQMSNGVYARIAILEAVLNSR
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: DEF_HELPS
Sequence: MALLEIIHYPSKILRTISKEIVSFDSKLHQQLDDMRETMIASEGIGLAAIQVGLPLRMLIINLPREDGVQHKEDCLEIINPKFIETKGTIMYKEGCLSVPGFYEEVERFEKVKIEYQNRFAEVKVLEASELLAVAIQHEIDHLNGVLFVDKLSILKRKKFEKELKELNKNPKSKS
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RL22_GRAFK
Sequence: MGVRKRERAEQIKEAKKQVAFAKLNNCPTSPRKMRLMADLVRGEKVEKALHILKFSKKEASNRLEKLLVSAIANWQAKNEDANLEEAELFVKEIRVDGGSMLKRLRPAPQGRAHRIRKRSNHVTLVLGANNNTQS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: OBG_SALNS
Sequence: MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAIAEALGWEGKYYLISAASQLGVKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQLAEVEEDADDDWDDDWDEDDEEGVEFIYKR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FDHE_ECOSM
Sequence: MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNLYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTTRIKEASAQGKPPLDIHVLPRDKHWQKLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCGSMPVSSMVQIGTTQGLRYLHCNLCETEWHVVRVKCSNCEQSGKLHYWSLDDEQAAIKAESCDDCGTYLKILYQEKDPKIEAVADDLASLVLDARMEQEGYARSSINPFLFPGEGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZBT24_DANRE
Sequence: MSALPPSSSSPAVLALHSATHKDTILHKFDTLRRSELLCDITLIVEDVHFKAHKALLAASSEYFSALFTAEEQVSQSLYKLDGMTANTFSSVLEFMYSAVVLVDESSSEQLMEMARFLVIPDLIKAHEDLQAVDEHMQVKRKRGRPKKNQDLSQKENPESELQAQTSSEIQEVNEEPASPATDGSDGEFNPREERRREGKRKIKQPIRLKGFRMDDLMEGKEPGKRGRRRKYPDTEARCEECGKVFKSHLFLKIHQRTHTGEKPFRCSVCGKEFTQKHTLLVHQRMHTGEKPYICTVCSKALSTKHSLLEHMNLHTENKLFTCEECGKSFSQQRQLKSHNRVHTGKGLPECAECHHKFMDAAQLKKHLRTHTGEKPFTCEICGKCFTAKSTLQTHIRIHRGEKPYVCKVCDKTFSDPSARRRHEVSHTGKKTFSCSICKVSFARKDNLKAHIKTHNKENPPAQAESTDKPPQSAPEQQEQEQQQQQQTSGDKELHSILQLQPFQLPAHGEQEIQLLVTGENLSLDQEQSISIITSEDTEQSLALLTQPSGHVQNLAVVTPDGNAQIQTISVLGGEVNGGDPEQMHVITLSKEAMEQLQVHHGAPQQLQVIHQLSEEQTGPVAGIHISGQSGQAISISQTTEQIPSDQIQGQTFQIQAGTVSYLYTTSMNPQN
What is the function of this protein?
May be involved in BMP2-induced transcription.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 24, Zinc finger protein 450.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NKL_HORSE
Sequence: MTSRALLLLASALLGTPGLTFSGLNPESYDLATAHLSDGEQFCQGLTQEDLQGDLLTERERQGIACWSCRKILQKLEDLVGEQPNEATINEAASRVCRNLGLLRGACKKIMRTCLRLISRDILAGKKPQEVCVDIKLCKHKAGLI
What is the function of this protein?
May be an effector molecule of cytotoxic activity.  Has antimicrobial activity (By similarity).
What are the official names of this protein?
Antimicrobial peptide NK-lysin.
What are the subcellular locations of this protein?
Secreted.
Protein: ORF24_TTVV4
Sequence: MSWRPPAHNAEGQEGLWYRSVCQSHGAFCGCGDFVGHLNRLAERLGRPQPPRPPGGPPGPAIRVLPALPPAEGSPRRHNRTENQPCGGGDADFGDQRDAGDGGAAADDLSPADVEDLLDWLDAPDRSKTPKNRGPRGRCRRRLTFQGEKTPSLARLDLGRNRERSRSPRREDATGAAPTAAQRATTAQMRNPVHVPAINKNAASPPRPSYPSISPKALLFPERLPQMWTKQDWETEQQAAAVWDRPMRNNLTDPPFYPWMPRYRVSLRLGFNPQ
What are the official names of this protein?
Uncharacterized ORF2/4 protein.
Protein: YL232_MIMIV
Sequence: MSNNIFTNNYTIVDKLSEGTYGIVYKVEHIESKKNFACKKFVIDNNFTYCNYNELIAHNEFNHSNLIEIYDILVDYGHDKCTYYVIMELCDGCLFDILFCDKVFLDESQRLDYLIQIIDGLEYMWSKGFVHNDLSLTNILVKNNKIKIADFGFMYNRFIKQDIYHRNTIYIQPPELISGHPRICDPNKIDTWALGQIFYVMCYNSVLYNYSNKTDYYLDIISKTNTPSLDIIDKLYLSDKYKKLYYNIFRKNIKKLTQNAINELVCYNKSTNKFSNDNLRKKTSSNKFIKKHMNWSVRHRPDIKQSRKLFYEILANKYPIYNSPIIQSIIPSTISFREFSFHKLWSSMNNYDYLFKSNLLFGIHFEYKIRLHHRFDYQYNLIVKIMLLMGKIIRSCFSKYNKFKCLNKFIYPNNNYLLSSQISRLENSFDRFYSMGKIIYCHYPFFENYIFDYDTIKLSNSLEFQYHFIDILDKEIPCLDAYDIFLLSNCNKMYQKYFKYMYYLFVSSPNATVFDNNIVYQSIMLIIISYKNSLIYKKLINQFLKLNISTKIKYSREINHCFNDDIINVIEIDNDYGINLNYFTVDTIITAYYIIHICRLITNEKYNLLNINFAIESKFIKYLDKLVSVIDME
What are the official names of this protein?
Putative serine/threonine-protein kinase L232.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: RL4_PYRAE
Sequence: MMNEVLLKFKQLDLSPYIQPLPEKPAEKLKVYGIDGAYVADIEAPLHFLEPIRPDLIRRAYLSALSARFQPKGVYEGAGKEHSCESFGVGLGIARIPRYKGSLWPRGCFAPNTRGGRRAHPPKVEKKLHEEINKKEKKLAIRSAIAATAYRSWVAARGHVVEKVPSLPVVVVGDAEKINRAKEAKKLFEALGLWPDVERAAEGVKIRAGKGKMRGRRYKEPKSVLVVVSDLNAPLIAAVRNFPGVDVVAVNNLNILVLAPGGVPGRLTLWTAPAVEKLRGLFL
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RS17_STRE4
Sequence: MERNQRKTLVGRVVSDKMDKTITVIVETKRNHPVYGKRINYSKKYKAHDEKNLAKEGDIVRIMETRPLSATKRFRLVEIVEEAVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ISPH_MYCVP
Sequence: MPPTVNMGIPGASRTALGSVAGDVTGKRVLLAEPRGYCAGVDRAVETVERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTDEVPEGAIVVFSAHGVAPTVHEEAAARHLRTIDATCPLVTKVHNEAKRFARDDYDILLVGHEGHEEVVGTAGEAPDHVQVVDNPDAVDKVTVRDPNKVIWLSQTTLSVDETMETVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSKNSSNSVRLVEVALGAGASAAHLVDYADDIDPAWFDGVTTVGVTSGASVPEILVRGVLDRLAEHGYDVVQPVTTANETLVFALPREIRPARQ
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RIP11_CRIRI
Sequence: RLCIPVIFPC
What is the function of this protein?
Induces mouse splenocyte proliferation through binding to CCK-BR.
What are the official names of this protein?
Riparin-1.1.
What are the subcellular locations of this protein?
Secreted.
Protein: PCDB6_MOUSE
Sequence: METTLAKTPEKRQVVFLAILLLLWEAGSEAIRYSIPEETESGYLVAHLAKDLGFRVGELATRRARIHHRGNKELLQLDVETGNLLLKEKPDREALCGATEPCVLHFQIILENPVQFFQTELQLTDINDHSPEFPDTEMLLKIQESTQPATVFLLKAAQDSDIGSNAVQNYTVSPNLHFHVVTLSRSDGRKYPELVLDRALDREEQPELTLILTALDGGAPPKSGTTTVRIEVVDINDNAPEFVQSLYSVEVPENSPLDALVVTVSARDLDAGIHGNVAYSLFQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGGLSGKCTVAIQVLDVNDNAPKLTISSLTSSIPENAPEAVVAVFSVSDPDSGDNGRMVCSIQNELPFLLKPTFENYYTLAAEGPLDREIREEYNITIIVSDLGTPRLTTQHTITVQVVDINDNAPAFTQTSYTMFVHENNNPALHIGTISATDSDSGSNAHITYSLLPPHDLQLSLASLVSINADNGQLFALRAMDYEALQAFEFHVVARDGGSPALSSQALVRVVVLDDNDNAPFILYPMQNASAPCTELLPRAAEPGYLVTKVVAVDSDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPRSASVTLHVLLVDGFSQPYLPLPEVQHDSSQDEDMLTLYLVIALASVSSLFLLSVLLFVGVRLCRRVREASLGACSVPEGHFSGHLVDVSGMGTLSQSYQYEVCLSGDSGTTDFKFLNHYSQ
What is the function of this protein?
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523).  Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523).
What are the official names of this protein?
Protocadherin beta-6, PCDH-beta-6.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GLSA_GLUOX
Sequence: MSTVASIIVSIAEEMRTASERGTVANYIPPLARVDLNRFGMAVVGMDGETHTVGDAEVPFSVQSVSKVFSLSMALNAMGDELWGRVRQEPSGSAFNSIVQLENEHGIPRNPFINAGAIVIADILVSRYGRENAQTRLLEFLRPLVSDPSSIDIDTDVARQERETGFRNMALANYMRTFGNIRNVVEDTLDFYFHQCALTMSCHQLAQVGTCLMTGGRNPLTGERIMSERNAQTILALMMMCGHYDGSGAFAIRVGLPGKSGVGGGILAIAPGVASIAVWSPGLNAQGNSLLGTRALERLVQHTGWSVFRANPWVANPT
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: PDXJ_CHESB
Sequence: MPVKLSVNLNAVAMLRNRRDLPWPSVTALGRIALGAGAHGLTVHPRPDQRHIRFSDLPHIRALIDDEFPDREFNIEGYPSEDFLRLVEETQPEQVTLVPDDPSQATSDHGWQFQEHERFLAAAVGRLKRRGFRVSLFADPDADEAALAVAKAVGADRVELYTGPYGACYDDAEKAAKELRKLEKTAKTAQGLGLAVNAGHDLTVANLPALVEHVPSLAEVSIGHALTADALEYGMAETVRRYLSACEA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_PSEF5
Sequence: MHCPFCGANDTKVIDSRLVAEGEQVRRRRECLACGERFTTFETAELVMPRLIKTDGSRQPFDEEKLRAGMQRALEKRPVSVERLEAALVHIKHKLRATGEREVKSLVVGELVMTELQKLDEVAYIRFASVYRRFQDLNEFREEIDRLAREPAKQ
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: DHQS_HALMA
Sequence: MTRSVWLKADSEVGDWETRKRRITAGIEAGVDWVLVDEEDVDRVSELGEINIAAFTNGDVHVMEAEAEDSEADATIVGKDGEGDGTVDLPSDFSGSADLSTLRQNGAAPDGGYVRIFDEDYEAFAEAVAAEADFTIVIGENWQIIPLENLIARVGEETDLIAGVRTAEDARTAYETLELGADGVLLDTDEVDEIRKTVEVRDEMGRESLDLEYAEVTAIEQTGSADRVCIDTGSLMEHDEGMLVGSMARGLFFVHAETAESPYVASRPFRVNAGAVHAYVRTPDGGTKYLSELQSGDEVQIVDANGRTREAIVGRAKIEKRPMFRVQAETEDSDRIETLLQNAETIKVHTQDGRTAVTDLEPGDEILIHHEDTATHFGERIEESIIEK
What is the function of this protein?
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
What are the official names of this protein?
3-dehydroquinate synthase, DHQ synthase, 3-dehydroquinate synthase II.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type DHQ synthase family.
Protein: THIM_STAA2
Sequence: MNYLNKIRIENPLTICYTNDVVKNFTANGLLSIGASPAMSEAPEEAEEFYKVAQALLINIGTLTAQNEQDIIAIAQTANEAGLPIVFDPVAVGASTYRKQFCKLLLKSAKVSVIKGNASEILALIDDTATMKGTDSDANLDAVAIAKKAYAIYKTAIVITGKEDVIVQDNKAIVLANGSPLLARVTGAGCLLGGVIAGFLFRETEPDIEALIEAVSVFNIAAEVAAENENCGGPGTFSPLLLDTLYHLNETTYQQRIRIQEVE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RUVA_LEPIC
Sequence: MISGLKGILRKLEVGFVHIETGGITYEVTISFKTYLELKNLPLLKEVQLQIFHSINERGQKLFGFLTEQDKEFFKVMKGLQGIGELTALKILSFFSAEDLYRIVQSGEVKELEKIPKVKGKTSEKIFFEVKQNLKKLELFLSGSSKESSVILTSLLQSPEEMAFSKKRETVILGLVQLGFEEKTASKEVDKVLKIFSSNDPGEIIREILKSL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: APYC1_BPSBS
Sequence: MAHTTQLTMVGTGSAFSKKFYNNSALVQFTNGYNLLIDCGHSVPKGLHDLGIPLESIDGILITHTHADHIGGLEEVALYNKFVLGGRKIDLLVPETLVEPLWENSLKGGLRYPDEDSPEPELSDYFTVRSLKTSDYGVAHTQIEENMAVRLYPTVHVSHMDSYAVGLVDRGEDKVFYSSDTIFDEYLIDYALTYPWVFHDCQFFTGGVHASLDELLNYIPEEDQARVFLMHYGDNLEDFFNKTGRMRFALQGRTYIL
What is the function of this protein?
Counteracts the host Pycsar antiviral defense system.  Phosphodiesterase that enables metal-dependent hydrolysis of host cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.
What are the official names of this protein?
Anti-Pycsar protein Apyc1, Apyc1.
What is the protein family that this protein belongs to?
Belongs to the anti-Pycsar protein Apyc1 family.
Protein: RNH_ACTP2
Sequence: MKLVEIFTDGSCLGNPGKGGIGIVLRYNGHEKQVSKGYLQTTNNRMELRAVIEALAMLKEPCQVQLNSDSQYMKDGITKWIFSWKKNNWKTANGKPVKNKELWIALDQEIQRHKIEWTWVKGHSGHRENEICDELAKAGANNPTLEDIGYNAD
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_NOCFA
Sequence: MSSNRKDDHVRHAVDQHRDRTPVNDFDAIGFQHHALAGIDAADVDLGVDIAGKRWHTPLFINAMTGGSAAATDINRGLAIAARETGLPVASGSLSAYFRDPGLAGSFRVLREENPHGVVIANVNATATLDQARRAVDLLAADALQIHLNAVQEIVMPEGDRSFRSWPRRIEHLAAGVPVPVIVKEVGFGLSRPTVAWLRDAGVAVADVGGRGGTNFARIENDRRPAADFSFLDTWGQSTPACLLDSAEVTGIALVASGGIRSPLDVAKALALGADATGVAGRFLATLLDRGAEGLIETIRAWLDQLRSIATVLGAATPADLRRCDLLITGEVAAFCRLRGIDAAAYAHRSHWWHPSERRSLL
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_THISH
Sequence: MAKRDYYEILGVAKNASEAELKKAFRRLAMKHHPDRNPGDKESEEKFKEAKEAYEILTDPQKRAAYDQFGHAGVDPSAGGGARGGASFSDIFEDIFGDIFGGGRGGGSRVYRGSDLQYNLELTLEEAVFGTEVKIRVPSLVECGECHGSGAEKGTTPETCGTCGGVGQVRMQQGFFSVQQTCPRCHGTGKMITHPCKACHGQGRVEEHKTLSVKVPAGVDSGDRIRLSGEGEAGINGGPPGDLYVQIHVKAHKLFTRKGNDLMCEVPISFATAALGGELEIPTLDGRVNLKIPEETQSGRLFRLRAKGVKSVHGGAQGDLICRVSVETPVNLTKRQKELLKELDETMKAGGTRHSPQEEGWLDGVKGFFEDLKFWNK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.