PharMolix/UniProtQA huggingface dataset:
Protein: RL23_PSESM
Sequence: MNQERVFKVLLGPHVSEKATVLADKKGQFVFKVATDATKLEIKKAVESLFSVKVERVTTLNVLGKSKRTARGLGKRNDWKKAVISLQPGQDLDFSSSAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: TO1F_ATRRO
Sequence: MNTATGVIALLVLATVIGCIEAEDTRADLQGGEAAEKVFRRSPTCIPSGQPCPYNENCCSQSCTFKENETGNTVKRCD
What is the function of this protein?
Insecticidal toxin that reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels (Cav) in cockroach DUM neurons.  Also causes a modest block of insect sodium channel currents (Nav).  Induces potent excitatory symptoms, followed by flaccid paralysis leading to death in house crickets (By similarity).
What are the official names of this protein?
Omega-hexatoxin-Ar1f, Omega-HXTX-Ar1f, Omega-atracotoxin-Ar1f, Omega-ACTX-Ar1f.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 08 (Shiva) family. 01 (omega toxin) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: METE_PSYIN
Sequence: MAKLHHLGFPRIGNKRQLKFALEKFWGGELSEQQLQTSAADLRQQNWLDQQDLALDLYTVGDFSLYDQVLDMSFLVGNIPSRAKQSEQDNSLDNYFRVARGRSQPQECCAASHGQSGESQAGEMTKWFNTNYHYIVPEFDAQTTFLLNAKQLLLQIEALQKINKNVKPVIIGPVTYLWLGKEKDNSQKLTLLPELLEVYAELLALFAEKNITWVQIDEPILVLEIPKQWQEALQSSYQKLGQSKVKLLLTTYFGELKNNLKLACELPIAGLHLDAVNAPHEIDSAIDYLGTDKILSLGIINACNIWKTDLNQTLNQLLPIHQKLQDRLWLAPSSSLLHVPIDLNNEDKLDYEVKSWLAFAVQKLQELSLIGRALNDGLSSVEAAFTYNKLCIENRRQSPQVHKQDIKSKVLNITPELGQRNLAIKQREALQQSYLNLPSYPTTTIGSFPQTSDIRQLRQAKRLGDINEEQYKKSIKESIEFCINEQDQLGLDVLVHGEAERNDMVEYFGELLDGFVFTQFAWVQSYGSRCVKPPILFGDVSRPKAMTVEWSSYAQSLTEKKVKGMLTGPVTILNWSFVRDDQPLQTTCMQIALAIREEVLDLEKAGINIIQIDEAALREKLPLHRSQWQQYLNWAIAAFRLCANGVNDKTQIHTHMCYSEFNDIIAAIAQMDADVITIETSRSDMVLLDVFEAFSYPNGIGPGVYDIHSPNIPDVEQMVSLMKKAALRIPAEQLWVNPDCGLKTRRWEEVKPALLNMVAAAKKLRAS
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: PLSY_AGRVS
Sequence: MPSLDYSQVTITALIASLAIGYLLGSIPFGLLLTRMAGLGDVRNIGSGNIGATNVLRTGNKKLAAATLLLDALKATAAALIAQKLFGSDTVHLPGLLGGFAAFIGHLFPVWLGFKGGKGVATYIGTLLGIFPLMVLVFAIVWLSIAFLSRYSSLSALVATLVIPVALWILGQPEAAMITSAMTVITWGKHKANIERLISGTESKIGKKG
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: METK_HALSA
Sequence: MTDRNIQVQSLDRSAVEDDAVEIVERKGLGHPDSICDGIAEHVCETLAREYRDRVGHVLHFNTDETQLVAGDAAPAFGGGNVIDPIYILVVGRATSHYVEADGTEHHIPVESIALEAAREYLRETLPHLDLETDVIVDVKLGEGSGDLQDVFTDDDDGPAVPMANDTSFGVGHAPLTETERIVLEAERSLNGPYAEHTPAVGEDVKVMGKREDDHIDLTIAAALVDAHVPDMDAYIAQVEAIREHVFDLATEHTDREVTVHVNTADDYESGSIYLTTTGTSAEQGDDGSVGRGNRANGLITPNRAMSMEATSGKNPVNHIGKIYNLLSTQIAEAVVAEVDGIRDLRVRLLSQIGRPIDEPHVADVEVVTEDGTAVADVDAEIERIVDAQLASVTDLTRRVIDGERTTF
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase 2 family.
Protein: P56_BPGA1
Sequence: MNKEKNSYRDAIKDVELTMMAIDSHFRTHKGFTDSYLLVMILENEVGETRLEVSEGLTFDEVGYIVGSVSDNILHMHTYNYCEKNREDIYKWLKASRIEKFKSDYAKMLMNMHFGKENNVGSNINLKEEF
What is the function of this protein?
Inhibits the host uracil-DNA glycosylase (UDG), an enzyme which removes uracil residues from DNA by the base excision repair (PubMed:21542855).  Interacts with host uracil-DNA glycosylase and prevents the latter from binding to DNA (By similarity).  Since the viral DNA polymerase efficiently incorporates dUMP into DNA, the virus needs to prevent the deleterious effect caused by host UDG when it eliminates uracil residues present in the viral genome (By similarity).
What are the official names of this protein?
Protein p56.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus protein p56 family.
Protein: AFUB_ECOLI
Sequence: MESLPGQIDKSLDEASLSLRAGSLRTITHILLPLLRPAILSALIYSFVRAITTVSAIVFLVTPDTRVATAYILNRVEDGEYGVAIAYGSILIVVMLAIIFIFDWLIGESRTSRSKAKNQA
What is the function of this protein?
A severely truncated paralog of the AfuB uptake protein, homologous only to the last 20% of the intact protein in Actinobacillus.
What are the official names of this protein?
Putative ferric transport system permease-like protein AfuB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FbpB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=When overexpressed using vectors that provide a promoter and ribosome binding site (PubMed:15919996).
Protein: MUTT1_MYCS2
Sequence: MMPVDDLQEIPLSKDTTEKSKHTVRAAGAVLWRDASEHGGTTGHPATVEVAVIHRPRYDDWSLPKGKLDQGETEPVAAAREIHEETGHTAVLGRRLGRVTYPIPQGTKRVWYWAAKSTGGDFSPNDEVDKLVWLPVDAAMDQLQYPDDRKVLRRFVKRPVDTKTVLVVRHGTAGRRSRYKGDDRKRPLDKRGRAQAEALVAQLMAFGATTLYAADRVRCHQTIEPLAQELDQLIHNEPLLTEEAYAADHKAARKRLLEIAGRPGNPVICTQGKVIPGLIEWWCERAKVRPETTGNRKGSTWVLSLSDGELVGADYLSPPDEK
What is the function of this protein?
Catalyzes the conversion of 8-oxo-dGTP to 8-oxo-dGDP, and 8-oxo-GTP to 8-oxo-GDP (PubMed:16585780, PubMed:28375146).  At high enzyme concentrations, can also catalyze the conversion of 8-oxo-dGDP to 8-oxo-dGMP, and 8-oxo-GDP to 8-oxo-GMP (PubMed:28375146).  In addition, catalyzes the hydrolysis of the diadenosine polyphosphates diadenosine hexaphosphate (Ap6A), diadenosine pentaphosphate (Ap5A) and diadenosine tetraphosphate (Ap4A) (PubMed:28705712).
What are the official names of this protein?
8-oxo-(d)GTP phosphatase, 8-oxo-(d)GTPase, 8-oxo-(d)GDP phosphatase, Diadenosine hexaphosphate hydrolase, Ap6A hydrolase, MsMutT1.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: PSD_ECO81
Sequence: MLNSFKLSLQYILPKLWLTRLAGWGASKRAGWLTKLVIDLFVKYYKVDMKEAQKPDTASYRTFNEFFVRPLRDEVRPIDTDPNVLVMPADGVISQLGKIEEDKILQAKGHNYSLEALLAGNYLMADLFRNGTFVTTYLSPRDYHRVHMPCNGILREMIYVPGDLFSVNHLTAQNVPNLFARNERVICLFDTEFGPMAQILVGATIVGSIETVWAGTITPPREGIIKRWTWPAGENDGSVALLKGQEMGRFKLGSTVINLFAPGKVNLVEQLESLSVTKIGQPLAVSTETFVTPDAEPAPLPAEEIEAEHDASPLVDDKKDQV
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL28_SERP5
Sequence: MSRVCQVTGKRPVSGNNRSHAMNATKRRFLPNLHSHRFWVEAEKRFVTLRVSAKGMRVIDKKGIETVLADLRTRGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RFBB2_KLEPN
Sequence: MEPVINFSNVTKEYPLYHHIGSGIKDLVFHPKRAFQLLKGRKYLAIEDISFTVAKGEAVALIGRNGAGKSTSLGLVAGVIKPTKGSVTTHGRVASMLELGGGFHPELTGRENIYLNATLLGLRRKEVQQRMERIIEFSELGEFIDEPIRVYSSGMLAKLGFSVISQVEPDILIIDEVLAVGDISFQAKCIKTIREFKKKGVTILFVSHNMSDVERICDRVVWIENHRLREIGSAERIIELYKQAMA
What is the function of this protein?
May form an ATP-driven O-antigen export apparatus, in association with RfbA.
What are the official names of this protein?
O-antigen export system ATP-binding protein RfbB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HEM6_SALEP
Sequence: MKPDAHHVKQFLLRLQDDICQKLSAVDGANFVEDSWRREAGGGGRSRVLRNGGIFEQAGVNFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGADPVWWFGGGLDLTPYYGFEEDAVHWHRTARDLCQPFGDNVYPRYKKWCDDYFFLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGNGYTEAYLPIVERRKAMVWGERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWI
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_JANSC
Sequence: MNQELTNNPFNPLTPPKAFDEIKVSLASPERILSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKYRGVVCEKCGVEVTLQKVRRERMGHIELAAPVAHIWFLKSLPSRIGLMLDMTLRDLERILYFENYVVIEPGLTDLTYGQLMGEEEFMDAQDAYGADAFQANIGAEAIREMLSQIDLESEANQLREDLKEATGELKPKKIIKRLKIVESFLESGNRPEWMVMTVVPVIPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLIELRAPDIIIRNEKRMLQESVDALFDNGRRGRVITGANKRPLKSLSDMLKGKQGRFRQNLLGKRVDFSGRSVIVTGPELKLHQCGLPKKMALELFKPFIYSRLEAKGLSSTVKQAKKLVEKERPEVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCSAFNADFDGDQMAVHVPLSLEAQLEARVLMMSTNNVLSPANGAPIIVPSQDMILGLYYVTLAREGMKGEGMIFADVDEVRHALDAGEIHLHSKITARLPQIDEEGNEIMVRFDTTPGRVMLGALLPLNAKAPFDLVNRLLRKKEVQQVIDTVYRYCGQKESVIFCDQIMSMGFKEAFKAGISFGKDDMVIPDTKWTLVEDARDQVEEFEQQYMDGLITQGEKYNKVIDAWSKVNDKVTDAMMGTISASKRDENDAEMEPNSVYMMAHSGARGSVTQMKQLGGMRGLMAKPNGEIIETPIISNFKEGLTVLEYFNSTHGARKGLSDTALKTANSGYLTRRLVDVAQDCIVRMDDCGTENTIKAEAAVNDGEVVASLAERILGRTAGEDVFIPGTDEIIVAKGELIDERKADAVEAAGVTTMQMRSPLTCEAEEGVCATCYGRDLARGTKVNTGEAVGIIAAQSIGEPGTQLTMRTFHIGGVAQGGQQSFQEVNVDGKVEFRNANLLKNANGESVVMGRNMVLAIMDDQGSERASFKLGYGTNVLVEDGKKVVRGDRLFEWDPYTLPIIAEAAGTAKFVDLVSGISIRDETDDATGMTQKIVSDWRTAPKGNELKPEIIIAGEDGEPMRNDQGNPVTYTMSVDAILSIEEGQTVKAGDVIARIPREGAKTKDITGGLPRVAELFEARRPKDHAIIAEIDGYVKFGRDFKNKRRIGIVPADESLEPVEYMVPKGKHIPVAEGDFVQVGDYIMDGNPAPHDILAVLGVEALADYMIDEVQDVYRLQGVKINDKHIEVIVRQMLQKWEIQDSGETTLLKGEHVDKAEFDSANAKAVRDGRRPAQGEPILLGITKASLQTRSFISAASFQETTRVLTEASVQGKKDRLVGLKENVIVGRLIPAGTGGATQDVERIAKGRDQVVIDAAQAEAEAAAALAAPVMEDAAPDTDAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: TOLA_PSEAE
Sequence: MKQQFERSPSESYFWPVVLAVVLHVLIFAMLFVSWAFAPELPPSKPIVQATLYQLKSKSQATTQTNQKIAGEAKKTASKQYEVEQLEQKKLEQQKLEQQKLEQQQVAAAKAAEQKKADEARKAEAQKAAEAKKADEAKKAAEAKAAEQKKQADIAKKRAEDEAKKKAAEDAKKKAAEDAKKKAAEEAKKKAAAEAAKKKAAVEAAKKKAAAAAAAARKAAEDKKARALAELLSDTTERQQALADEVGSEVTGSLDDLIVNLVSQQWRRPPSARNGMSVEVLIEMLPDGTITNASVSRSSGDKPFDSSAVAAVRNVGRIPEMQQLPRATFDSLYRQRRIIFKPEDLSL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolA.
What is the protein family that this protein belongs to?
Belongs to the TolA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: KNRL_DROME
Sequence: MMNQDNPYAMNQTCKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNLSSISDCKNNGECIINKKNRTACKACRLKKCLMVGMSKSGSRYGRRSNWFKIHCLLQEQQQQAVAAMAAHHNSQQAGGGSSGGSGGGQGMPNGVKGMSGVPPPAAAAAALGMLGHPGGYPGLYAVANAGGSSRSKEELMMLGLDGSVEYGSHKHPVVASPSVSSPDSHNSDSSVEVSSVRGNPLLHLGGKSNSGGSSSGADGSHSGGGGGGGGGVTPGRPPQMRKDLSPFLPLPFPGLASMPVMPPPAFLPPSHLLFPGYHPALYSHHQGLLKPTPEQQQAAVAAAAVQHLFNSSGAGQRFAPGTSPFANHQQHHKEEDQPAPARSPSTHANNNHLLTNGGAADELTKRFYLDAVLKSQQQSPPPTTKLPPHSKQDYSISALVTPNSESGRERVKSRQNEEDDEARADGIIDGAEHDDEEEDLVVSMTPPHSPAQQEERTPAGEDPRPSPGQDNPIDLSMKTTGSSLSSKSSSPEIEPETEISSDVEKNDTDDDDEDLKVTPEEEISVRETADPEIEEDHSSTTETAKTSIENTHNNNNSISNNNNNNNNNNNSILSDSEASETIKRKLDELIEASSENGKRLRLEAPVKVATSNALDLTTKV
What are the official names of this protein?
Knirps-related protein, Nuclear receptor subfamily 0 group A member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR0 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEF2_NPVAC
Sequence: MANASYNVWSPLIRASCLDKKATYLIDPDDFIDKLTLTPYTVFYNGGVLVKISGLRLYMLLTAPPTINEIKNSNFKKRSKRNICMKECVEGKKNVVDMLNNKINMPPCIKKILNDLKENNVPRGGMYRKRFILNCYIANVVSCAKCENRCLIKALTHFYNHDSKCVGEVMHLLIKSQDVYKPPNCQKMKTVDKLCPFAGNCKGLNPICNY
What is the function of this protein?
Plays an essential role in viral DNA replication.  Does not seem to participate in the initiation step but is rather important for the amplification of DNA.  Also required for expression from the vp39 and polh promoters.
What are the official names of this protein?
Primase-associated factor LEF-2.
What is the protein family that this protein belongs to?
Belongs to the baculoviridae LEF-2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host cytoplasm. Note=Colocalizes with the active viral DNA replication sites in the nucleus of infected cells.
Protein: Y004_MYCLE
Sequence: MIESNESYSYGGDTIEPLGTLSGFDLVRRALEEARAAACAQGKDAGRGHVVPPVPFRVTDRRRNWSGPGPDVRDPQPLGKVAHDLAKKRGWSAQVAEGRVFGQWASMVGGQIADHAFPVGLNNGVLSVTAESTAWATQLRIMQAQLLAKIAAAVGNGVVTSLKITGPTAPSWRKGPWHIAGRGPRDTYG
What are the official names of this protein?
UPF0232 protein ML0004.
What is the protein family that this protein belongs to?
Belongs to the UPF0232 family.
Protein: CLPP_CERS4
Sequence: MKDPIDLYMNTLVPMVVEQTSRGERAYDIYSRMLKERIIFLSGPVHDGMSSLICAQLLFLEAENPSKEIAMYINSPGGVVTSGLSIYDTMQYIRPKVSTLVIGQAASMGSLLLTAGEKGMRFSLPNSRVMVHQPSGGYQGQATDIMIHARETEKLKRRLNEIYVRHTGQDLETVEAALERDNFMSAEDAKAWGLIDEILESRNRPDDTAK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC65_HUMAN
Sequence: MARVAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLAAAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPAPAAKPDPDGGRADEWACELRLFGRVLERAACLRRCKRTLPAFQVPYPPRQLLRDFQSRLPYQYLHYALFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYQGMLDVADESLTDLEAQPYEAVFLRAVKLYNSGDFRSSTEDMERALSEYLAVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGYFVDKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEEEDFQPREEAMLYHNQTAELRELLEFTHMYLQSDDEMELEETEPPLEPEDALSDAEFEGEGDYEEGMYADWWQEPDAKGDEAEAEPEPELA
What is the function of this protein?
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils.  Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.
What are the official names of this protein?
Endoplasmic reticulum protein SC65, Leprecan-like protein 4, Nucleolar autoantigen No55, Prolyl 3-hydroxylase family member 4, Synaptonemal complex protein SC65.
What is the protein family that this protein belongs to?
Belongs to the leprecan family.
Protein: TRX1_ORYSJ
Sequence: MVIAVEGGFVHEEEEVDHPIRYLPLGRVYSSSAPCPLPKKPRSAEDGKPPVIVYYRRRRKKPRVEGPPPSPATAPPMLHPREDDEDEEVTRRKGSLKYELLSLGQAPPALGGDGEEPARRRCLRRSGGAERRGYFSEPKRRQRQGVHKEAASSAGRRWLELEIEAADPLAFVGLGCKVFWPLDEDWYKGSITGYNEATKKHSVKYDDGESEDLNLADERIKFSISSEEMKCRNLKFGISNLNKRGYDELLALAVSLHDYQGLDPGDLVWAKLTGHAMWPAVVVDESNVPANRALKPGRLDQSILVQFFGTHDFARIKLKQAVPFLNGLLSSLHLKCKQARFYRSLEEAKEFLCTQLLPENMLQLQKSMEKGSSDANSNKDVHSCDNLSEDKTAESGGDYDEMTPIELGNLRVSKLGRIVTDSDYFHNKKHIWPEGYTAFRKFRSVKDPHVVILYKMEVLRNSDIKARPLFRVTSEDGTQIDGSTPNTCWKEIYCRLKEKQRNVASGLDRDVCQGSGSYMFGFSNPQIRQLIQELPNARSCLKYFENAGDTFRGYRAVHVNWKDLDYCSVCDMDEEYEDNLFLQCDKCRMMVHARCYGELEPLNGVLWLCNLCRPEAPRVSPRCCLCPVTGGAMKPTTDGRWAHLACAIWIPETCLKDVKRMEPIDGLSRINKDRWKLLCSICGVAYGACIQCSHPTCRVAYHPLCARAADLCVELEDDDKIHLMLLDEDEDPCIRLLSYCKKHRQPSTERPSLESNLAKPAVVVQTDAVPPSGCARTEPYNIHGRRGQKQPQVMATASVKRLYVENMPYIVSGFCQNRVGHDAISEPIQSVGFLDVAHQEAVGNVSSMIEKYKSMKATFRRRLAFGKSRIHGFGVFAKVSHKAGDMMIEYIGELVRPPISDIRERRIYNSLVGAGTYMFRIDDERVIDATRAGSIAHLINHSCEPNCYSRVISVLGDEHIIIFAKRDINPWEELTYDYRFVSSDQRLPCYCGFPKCRGVVNDVEAEGQSAKIRVNRSELFQQ
What is the function of this protein?
Possesses histone H3 methyltransferase activity in vitro (PubMed:24420930).  Methylates 'Lys-4' of histone H3.  H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.  Functions as a receptor for the lipid messenger phosphatidylinositol 5-phosphate (PI5P), which regulates negatively its transcriptional activation activity (By similarity).  Involved in the regulation of flowering time and floral induction under long day (LD) conditions.  Acts as an activator of flowering under LD conditions.  May function through binding to EHD3, a repressor of GHD7 (PubMed:24420930).
What are the official names of this protein?
Histone-lysine N-methyltransferase TRX1, OsTrx1, Protein SET DOMAIN GROUP 723, SET family protein 33, OsSET33.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MEND_SHEAM
Sequence: MDHLHSSTAELNLLWGSLILEELTRHGVMHLCMAPGSRSTPLTLAAAAQDKLTRHLHFDERGLGFLALGLAKASQAPVAIITTSGTAVANLYPAIVEASLTHVPLIILSGDRPWELIGCGANQAIEQLGIFGGYARQLNLPTPDLRIGPEVLLSALDEQLANLDRPLHINCMYPEPLYPSEHRFDQFDSYLSRLGQWQDTQVPYLSVANASLSAFPPRDAMMRFVHGKGVIVAGTLTEAETPTELITLSQKLGWPLLTDAQSQLRQHPGAIGHIDQLLLNPRARALLDQAERVLVFGGRLLSKRLISYLAEKDWHSYWQVLPHQERLDPSHSNKQLWLGRAGDVCALEWPRSSEANWAASLISLNQSVEQDFIHHIDGGEFGEAQVIRAIAASHTAEQQLFIGNSLPVRLYDMFAPIGCCAASTYTNRGASGIDGLIATACGVARHSGRPTTLILGDLSALHDLNSLALARDCQSPLVIVVLNNDGGNIFNLLPVPTEELRSDFYRLSHGLEFGYGAAMFGLPYDRAEDMEAFIDAYQAALEHPGASVIEVTVAQDQASNQIRRMAEWIRSR
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: RNFB_PASMU
Sequence: MIITTVYFILVAIAVLALIFGAILGFASVKLKVEADPIVEKIDALLPQSQCGQCGYPGCKPYAEAIANGDDITKCIPGGQTVIVNIAELMGVEPPTTDIEGDPAPMVAFIDEDMCIGCTKCIQACPVDAIIGTNKAMHTIIPDLCTGCELCVPPCPTDCISMIKVESTIHNWNWKFDPKLVIPIVDTTTTQKKLIKGE
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: HIS6_SYNSC
Sequence: MVALRLIPCLDVARGRVVKGVNFVGLRDAGDPVELACRYSRAGADELVFLDIAASHEGRGTLIDMVRRTAESVTIPFTVGGGISTVEGITELLRAGADKVSLNSSAVRRPELVREGADQFGCQCIVVAIDARRRDAGGWDVYVKGGRENTGLDVVEWAQRVAGLGAGEILLTSMDGDGTQAGYDLALTRAVADAVPIPVIASGGAGCLDHIAEALDVGPTGGHASAALLASLLHDGVLTVEEIKQDLLSRGLTIRP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_XYLF2
Sequence: MLKKSDFHYDLPEELIAQGPLPERSASRLMLVPSAPEQFQDCYVRDLPELLQPGDLLVFNDTRVIPARLFGRKVSGGRVELLIERFLGTHQAVVQLRTSRSLKVGNRILLDAGGHAEVLGRDGEFYLLSFDVESPLEQWLSDVGQLPLPPYIHREPDEYDRERYQTVFARSVGAVAAPTAGLHFDESLLARLRARGVEFGYITLHVGAGTFQPVRVALLQEHVMHSEWFKVGAELVEQVRSARARGGRVIAVGTTVVRSLESAMRHGELQPFVGETQIFIFPGYCIRSVDAMVTNFHLPESTLLMLVAAFAGRTRILDAYYHAVQQRYRFFSYGDAMLLFPRNAGEQ
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSN8_ASHGO
Sequence: MSASYWDSSQRNKWQYSRESLARTRQKLWMLECQLYPQGTNILMEGGGKDAQPVTKNIPITHRDLHYDRDYNLRIYCYFLIMKLGRRLNVRQYALATAHVYLARFCLKASIREVNLYLLVTTCIYLACKVEECPQHIRTLVNEARSLWPEFVPPDPTKVTEFEFYLIEELQSYMIVHYPYRAMEQIAAALRRPPYNLVLSPDDLQNSWSLINDSYITDVHLLYPPHVIAMACLFITVCLRSAAGARDLQETFNRFMADSQVDLHEVMDTIQDFITLYDHWDKYNEPWIKFLLHNLYLRPHAGGTTVSGAAAGSAGPAGSVLTPNGTITGSTS
What is the function of this protein?
Component of the SRB8-11 complex.  The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
RNA polymerase II holoenzyme cyclin-like subunit.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSP23_DROME
Sequence: MANIPLLLSLADDLGRMSMVPFYEPYYCQRQRNPYLALVGPMEQQLRQLEKQVGASSGSSGAVSKIGKDGFQVCMDVSHFKPSELVVKVQDNSVLVEGNHEEREDDHGFITRHFVRRYALPPGYEADKVASTLSSDGVLTIKVPKPPAIEDKGNERIVQIQQVGPAHLNVKENPKEAVEQDNGNDK
What are the official names of this protein?
Heat shock protein 23.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.