PharMolix/UniProtQA huggingface dataset:
Protein: OV251_ONCVO
Sequence: MSLFRYNPRDYFYTSPMERFIVNLLDNTFDDRSSRPLHSVAPYWLHQPELNECNIGNTLGEVINEKDKFAVRADVSHFHPKELSVSVRDRELVIEGHHKERADSAGHGSIERHFIRKYVLPEEVQPDTIESHLSDKGVLTICANKTAVGTTASRNIPIRASPKEPEAKQKTKKQ
What are the official names of this protein?
Small heat shock protein OV25-1.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: TYRR_SALTY
Sequence: MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFAELEFTDFSSLMAEIRRISGVTDVRTVPWMPSEREHLALSALLEALPEPVLSLDMKSKVEMANPASCQLFAQSQERMRHHTAAQLINGFNFQRWLDGNPQSSHNEHVVINGQNFLMEITPVHLQNENDEYVLTGAVVMLRSTIRMGQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQARKLAMLSAPLLITGDTGTGKDLFAYACHQASPRSAKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEIGEMSPRMQAKLLRFLNDGTFRRVGEDHEIHVDVRVICATQKNLVELVQKGLFREDLYYRLNVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLSADLSTVLTRYGWPGNVRQLKNAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQLYRSYPSTRKLAKRLGVSHTAIANKLREYGLSQKKGEE
What is the function of this protein?
Dual transcriptional regulator of the TyrR regulon, which includes a number of genes coding for proteins involved in the biosynthesis or transport of the three aromatic amino acids, phenylalanine, tyrosine and tryptophan.  These three aromatic amino acids act as effectors which bind to the TyrR protein to form an active regulatory protein.  Acts by binding specifically to TyrR boxes in the promoter region of the target genes.
What are the official names of this protein?
HTH-type transcriptional regulatory protein TyrR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLCX2_MOUSE
Sequence: MLAFRKARRKLRMGTICSPNPSGTKTASEVCNADWMASLPAHLHNVPLSNLAIPGSHDSFSYWVDEKSPVGPDQTQAVIRLARISLVKKLMKKWSVTQNLTFREQLEAGIRYFDLRVSSKPGDTDQEIYFIHGLFGIKVWDGLMEIDAFLTQHPQEIIFLDFNHFYAMDESHHKCLVLRIQEAFGNKLCPACSVESMTLRSLWEKKYQVLIFYHCPFYKQYPFLWPGKKIPAPWANTTSVQKLILFLETTLSERAPRGAFHVSQAILTPRVKTIARGLVGGLKNTLVHRNLPAILDWVKTQKPGAMGVNIITSDFVDLIDFATTVIELNDLLEDRALTKC
What are the official names of this protein?
PI-PLC X domain-containing protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RD23B_MOUSE
Sequence: MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILSDDTALKEYKIDEKNFVVVMVTKPKAVTTAVPATTQPSSTPSPTAVSSSPAVAAAQAPAPTPALPPTSTPASTAPASTTASSEPAPAGATQPEKPAEKPAQTPVLTSPAPADSTPGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVDPPPQAVSTGTPQSPAVAAAAATTTATTTTTSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGSQGGGGGGGGGGGGGGGGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNFDED
What is the function of this protein?
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex.  The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs.  The orientation of XPC complex binding appears to be crucial for inducing a productive NER.  XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery.  Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation.  Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.  In vitro, the Xpc:Rad23b dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.  Xpc:Rad23b contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side.  Xpc:Rad23bB induces a bend in DNA upon binding.  Xpc:Rad23b stimulates the activity of DNA glycosylases Tdg and Smug1 (By similarity).
What are the official names of this protein?
UV excision repair protein RAD23 homolog B, HR23B, mHR23B, XP-C repair-complementing complex 58 kDa protein, p58.
What is the protein family that this protein belongs to?
Belongs to the RAD23 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: VL2_HPV29
Sequence: MVAHRARRRKRASATELYKTCKVAGTCPPDVIPKVEGTTLADRILQWGSLGVYLGGLGIGTGSGTGGRTGYVPVGTRPGTVVDVSIPTRPPVVIEPVGPSDPSIVTLLEESSVINSGATIPTFTGTSGFEITSSATTTPAVLDITPAGDNVVITSTNFNNPLFTEPSLLEIPQTGETSGRVLVGTPTSGVHGYEEIPMDTFATSGTGLEPISSTPVPGVSRVAGPRLYGKALTQVRVSDPAFLTQPSSFVTFDNPVYDPEDETIIFERPSPGTRVPDPDFMDIVKLHRPALTSRRGTVRFSRVGQKFSMRTRSGTNIGARVHYYHDLSPILPTEDIELEPLLPPADPTAEESLYDIYADVDEADMAFTGGGRGATTYGGRITPSVFSSTLSTRYGNVTIPFVSPVDVPLHTGPDIILPSSAQWPFVPVAPADTTHYVYIDGGDYFLWPVTFPVSRKRRRKRLSYFLADGFVAL
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: RL22_NITEU
Sequence: METSAVLRSVRLSAQKGRLVADQIRGLQVERAIRLLTFSPKKGASIILKLLESAVANAEHNEGADIDELKISQIFIGQGATLKRVSPRAKGRGNRISKPTCNIFLTVSNK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: FOLB_STAAN
Sequence: MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLAEAGRTDNVIDTVHYGEVFEEVKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVRENK
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.  Can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin.
What are the official names of this protein?
Dihydroneopterin aldolase, DHNA, 7,8-dihydroneopterin 2'-epimerase, 7,8-dihydroneopterin aldolase, 7,8-dihydroneopterin epimerase, Dihydroneopterin epimerase.
What is the protein family that this protein belongs to?
Belongs to the DHNA family.
Protein: PI3K1_SOYBN
Sequence: MTGNEFRFFLSCDISVPVTFRVERLEGNLPLPNPKSPDLETNAPTENRTKELFVECALYIDGAPFGLPTRTRLESSGPSYCWNELITLTTKYRDLTAQSQLTFTVWDLSHGEGLIGGATILLFNNKKQLKTGKQKLRLWAGKEADGTFPTSTPGKVPRHERGELERLEKLVNKYERGQIQRVDWLDRLTFKTMERIKERESLKNGSSHLYLVVDFCSFEHRVVFQESGANFLFPSPIASTNDIVVVWDPEVGKINPSEHKQLKLARSLTRGVIDRDLKPSSNERKSIQRILKYPPTRTLSGDERQLLWKFRFSLMSEKRALTKFLRCVEWSDVQEAKQALELMGKWEMIDVCDALELLSPVFESEEVRAYAVSVLERADDEELQCYLLQLVQALRFERSDKSRLSHFLVQRALRNIELASFLRWYVAVELYDPAYAKRFYCTYEILEENMMKIAAGVNGEEDGFKQWQSLVRQTELTAQLCSITREVRNVRGNTQKKIEKLRQLLSGLLSELTYFDEPIRSPLAPGVLIAGIVPSESSIFKSALHPLRLSFRTANGGTCKIIFKKGDDLRQDQLVVQMVSLMDRLLKLENLDLHLTPYKVLATGQDEGMLEFIPSRSLAQILSENRSIISYLQKFHPDDHGPFGITATCLETFIKSCAGYSVITYILGIGDRHLDNLLLRNDGGLFHVDFGFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFYLMAGSNIPDIASDPEKGILKLQEKFRLDLDDEASIHFFQDLINESVSALFPQMVETIHRWAQYWR
What is the function of this protein?
Associated with membrane proliferation.
What are the official names of this protein?
Phosphatidylinositol 3-kinase, root isoform, PI3-kinase, PI3K, PtdIns-3-kinase, SPI3K-5.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
Protein: DFB43_RAT
Sequence: MRLLLSILGVLTLLSILPLARSFLANQECFSEYRHCRMKCKANEYAIRYCADWTICCRVKKREAKKKIMW
What is the function of this protein?
Has bactericidal activity.
What are the official names of this protein?
Beta-defensin 43, BD-43, Defensin, beta 43.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NAGK_ERWT9
Sequence: MFYGFDIGGSKIALGVYNAHRQLIWQRRVATPKDDYAQLLAAIDTLTQQADGFCGVRGSVGIGVPGLPIADDGTIFSANIPAARGRTLRADLSARLGREVRIDNDANCFALSEAWDDEFMQYPVVLGMILGTGVGGGLIVDGKPVTGRNYVVGELGHMRLPVDALRVLGRDIPLLPCGCGKYGCIEGYLSGNGFSWLWHYFYQKTHSAPEIIRRYYEGDTDALAHTERYRELLAVCLGNILTLLDPHLVVLGGGLSNFDALYDGLSERVSSHLLPVARPPRFERARHGDAGGMRGAAFLHLKF
What is the function of this protein?
Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
What are the official names of this protein?
N-acetyl-D-glucosamine kinase, GlcNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NagK subfamily.
Protein: YCTB_SCHPO
Sequence: MESIQSTMKNINLYDIKAAVRKAQNVVMNYTSMEARVREATNNEPWGASTSLMMEIAQGTHNYSQLNEILPMIYRRFTEKTAEEWRQIYKALQLLEFLVKNGSERVVDDARAHQATIKMLRNFHYIDHRQKDQGLNVRTRAKELVELLNDSERIRKERKRARQNRGKFIGVGSDGDSRISTSSKSRFPSFGSSRGSYRTRVYGDGGGFTDYGNGYHDSSSMSDSRDASDNDVEEYNEDGDGGSSDAATANSTRGSRRTTTKQSDKAPEQPKQESAMIDLLGLDNEPSPAQPQTNTSAPLAFEDDGFGDFQSSAAAPASSTLNNASLFMGSQTASTAAKNDDDAFDDFQSAPSAKPASNTAAFSSISFGGFNSLNQLPTSSSAFTPQPTTFNTGYTSAFGMSSGLSNTSSQAGLGLTSQQPTAAKSSGSNGDAFGSLWSSAVNKVHQENSTRERVVSSSSEPVSKTQNFLDNDNLLL
What are the official names of this protein?
ENTH domain-containing protein C794.11c.
Protein: RNAS2_SAISC
Sequence: MVPKLFTSQICLLLLLGPLGVEGSLHAKPRQFSWAQWFSIQHIQMAPLRCTYAMRAINKYERRCKNQNTFLHTTFADVVNVCGNTNMTCPRNASLHNCHHSRVQVPLTYCNLTGPPTISNCVYSSTQANMFYVVACDNRDPRDSPQYPVVPVHLDTII
What is the function of this protein?
This is a non-secretory ribonuclease.  It is a pyrimidine specific nuclease with a slight preference for U.  Cytotoxin and helminthotoxin.  Possesses a wide variety of biological activities (By similarity).
What are the official names of this protein?
Non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2, RNase 2, Ribonuclease US.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Lysosome. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.
Protein: HPM4_HYPSB
Sequence: MSWESPVNYSVGGEDLDLDLGAFLGSLSDFDGQIEPAHSLEDEYSGQSGQGADDDPDSDGPKVLTIMASIDAIHRHLENERKKGNGKANVAIKLKDPTMRKSITFSIPELQSPTTTASSAGSPSCAPLRLPSPEAFDLGEAIFSHPTAGSSFPEEVTPAAEDDVLSSIASPFATPEGLFFPQDEDVLPSIAPLLKAANLAHATEPSLGLISPRATASESSMMPDEEAMADVVQYRDGTGTTPESLSPGDMEQDEWPHTVSSRQTRSRQAARACQTPSTMSTKDKKCIDSSSCSLKQMNSQHQKRNSIETAPSRTIKRPRVESPDLLTLIPNHDEYQRVQELTAALDPLLAYKMVRNARAILPQSVAEDMAHSADMEVDGPLHYQNNQQSPSSQEEIMQQFCETVRRIEWVERAAFKSMVEYRVLFVQLYQHYLRLQEIVVTRKGERRVTLAKEQLYRTLYPGVEKMTSSGLTSDEWEKFNRCIRRGKQWNTIASKLGVGILQRMPSSICHSWVEQKLQTKEQLHIWIEIVSLLA
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of hypothemycin, a resorcylic acid lactone (RAL) that irreversibly inhibits a subset of protein kinases with a conserved cysteine in the ATP binding site such as human ERK2 (PubMed:18567690).  The first step is performed by both PKSs hmp3 and hmp8 and leads to the production of 7',8'-dehydrozearalenol (DHZ) (PubMed:18567690, PubMed:20222707).  The highly reducing PKS hpm8 synthesizes the reduced hexaketide (7S,11S,2E,8E)-7,11-dihydroxy-dodeca-2,8-dienoate, which is transferred downstream to the non-reducing PKS hpm3 (PubMed:20222707).  Hpm3 then extends the reduced hexaketide to a nonaketide, after which regioselective cyclization and macrolactonization affords DHZ (PubMed:20222707).  The next step is the conversion of DHZ into aigialomycin C and is performed by the O-methyltransferase hmp5, the FAD-binding monooxygenase hmp7, and the cytochrome P450 monooxygenase hmp1 (PubMed:18567690).  The wide substrate tolerance of the hmp5 and hmp7 implies that the reactions from DHZ to aigialomycin C can occur in any order (PubMed:18567690).  The steps from aigialomycin C to hypothemycin are less well established (PubMed:18567690).  The FAD-linked oxidoreductase hmp9 presumably catalyzes oxidation of the C-6' hydroxyl to a ketone (PubMed:18567690).  The timing of this oxidation is important, since the resulting enone functional group is a Michael acceptor that can react spontaneously with glutathione, an abundant metabolite in fungal cells (PubMed:18567690).  The glutathione S-transferase hmp2 catalyzes cis-trans isomerization of the 7',8' double bond with equilibrium favoring the trans isomer (PubMed:18567690).  The hpm6-encoded transporter might preferentially pump hypothemycin out of the cell relative to the trans isomer aigialomycin A.  The cis-to-trans isomerization may be coupled with C-4' hydroxylation, since all known hypothemycin analogs containing the enone functional group also have hydroxyl groups at both C-4' and C-5' (PubMed:18567690).
What are the official names of this protein?
Hypothemycin biosynthesis cluster protein hpm4.
Protein: MURG_SYNJA
Sequence: MNGDRRDPTSPPRLLVAASGTGGHIFPALAVVEQLPTWQIEWLGVPQRLEAKLVPDRYPLHRVAMSGWQGSPWQKLGSLVQLARATLQVRQILASGQFDVVLTTGGYIAAPTILAARSLGVPVLLHESNCLPGKVTRWLGRFCRLVALGMAETAEHLPGAVTRVVGTPVRAEFYQPQPLPADLPIPEGDPLIVVMGGSQGARGLNRLVAACAPAWLEAGAWIVHLTGGSEVGIPSHPRYRAFPFRADVAALLQRATFAISRAGALSLAELWATATPAILIPYPFAAEDHQYHNALAFVGRGGGVVMRESEANLDLLRQTALAWLAQPQVVAQMAANLKATAPPAASKAVARLLQEICRDSAR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y075_ACTP2
Sequence: MFGKGGLGGLMKQAQQMQERMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRIEIDPSLMEDDKEMVEDLVAAAFNDAVRRAEEMQKEKMASVTAGMQLPPGMKFPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein APL_0075.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SEPF_NOCFA
Sequence: MSTLHKFKAYFGMVPLEDYEDDYVDDRAPRASERGGARGPRPYSERAGYGADRYGEDRYSADRFGPERFGAERFGPDRFGADRFDEDADYPEPAYKSYKSGYPVARRDDYPEDAYGEDRYEAPRRPTRIDAAPSSGRFRAGGGAPMLRGATRGALAVDPEAEERRLEERMRPEPVVARRPGIFEDGGPLSKITTLRPRDYSEARIIGERFREGNPVIMDLVELSNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSAEERRRIAETGFYNQK
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: PCKA_PSEA7
Sequence: MTQANNAVYTDISAAQLVEEAIRRGEGELAANGSLVVRTGHRTGRSPVDRFIVEEPSTKDAIAWGNINRPFPADKFDALWARVEAFNNAQDHFVSHVHVGAAEAYYLPVKMTTATAWQNLFGRCLFIEPEQYNPAGKDEWQVLNVANFECVPERDGTNSDGCVILNFAQKKVLIAGMRYAGEMKKAMFSVQNFLLPERDVLPMHCAANIGEAGDVTLFFGLSGTGKTTLSADESRYLIGDDEHGWGEGVVFNVEGGCYAKCIDLSEKNEPVIWKAIKFGAVLENVVLDEERVPDYADDSLTQNSRAAYPLEHVEKRSEKNLGGEPNAVIFLTCDLTGVLPPVSILNNEQAAYHFLSGYTALVGSTEMGSGGGIKSTFSTCFGAPFFPRPAGVYAELLIKRIKAFGSKVYLVNTGWTGGGYGVGKRFNIPTTRGVIAAIQSGALVDAETEHLDIINLDVPKAVPGVETNLLNPRNTWADKAAYDEAAKGLARQFIENFKKFEVSDAIKAAGPQL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_CAUVC
Sequence: MRIEFVPVDTQAGATAALAVLAHEGAALSPEARAANEATGGALARAIAGGRFTGAKGQTLDIVAPNGLEAARVVLVGVDGSGAVEPEAVELAAASAFQAVKTSGVVELVLKLGADAETAARAAFGARLAAYRFDKYRTTEKAEKKPSVQVVKIAAADPVKAQKAYEPLAALADAIVFSRNLVSEPANILHPEEFAARAKGLESLGLEVEILGEAEMAKLGMGSLLGVGQGSVRESQLVIMKWMGAADKSAQPIAFVGKGVCFDTGGISIKPADGMEDMKWDMGGAAAVAGVMHALAGRKAKVNAIGVLGLVENMPDGNAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQERFKPQFMIDLATLTGAIIISLGHDYAGLFSNNDGLSEKLLAAGKAERESLWRLPLPAAYEKQIESPIADMKNIGGRPAGSITAGLFLQKFVNGVPWAHLDIASVAWKKPSADPTVPDGAVGYGVRLLNRLVADAYEG
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOCS3_DROYA
Sequence: MMESEVDSEQSRLKREIAELRAALNRKEQCLRELEASVSSDASAEEQVVGNALESPGRAVHTKLTNDDIARYSRQLILPDFGVQGQLKLKNSSVLIVGLGGLGCPAAQYLAAAGCGRLGLIDYDEVERSNFHRQILHSESRCGMSKAESARIALLELNPHCEIHCHSRLLYSQNALHIIRGYDVVLDCSDNVPTRYLLSDACVMLRKPLVSGSALKMDGQLTVYNYGNGPCYRCIYPVPPPPEAVTNCGDGGVLGAVTGTIGAMQALEAIKVIVGLGDVLAGRLLIFDGSSGLFRNIRIRSKRPNCHVCSAQPLITELIDYEMFCGMHATDKDNPLQLLSTDERLSVKDYHAKLQAQPHLLIDVRPTAEFEICQLPEAVNVPLVEILDDSYLKRFGKQLEDKELPIILLCRRGNDSQIAVQHVRNRFPMHSVRDLIGGLHAWTNSVDPSFPIY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Also essential during biosynthesis of the molybdenum cofactor.  Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A.  Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase MOCS3, Molybdenum cofactor synthesis protein 3, Ubiquitin activating enzyme 4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMG7_ARATH
Sequence: MMTLQMDKTTASSSWERAKSIYDEIAELANKRQKAGNPPDPNLLQLLREKYEAIILESHTFSEQHNIEIPLWQLHYKRIEYFRLHINRVLASSTSTAAQNVKGPSKAEQIAQLKLQFRTFLSEATGFYHDMILKIRSKYGLPLGSFSEDQQSQNLSDKDGKELAEVQKALKSCHRCLIYLGDLARYKGMYAEGDSRSRQYASASSYYLQAASLWPASGNPHHQLAIVASYSRDEFVTTYRYFRSLAVEYPFPTARDNLIVAFDKNRQSYEKLFVPSKDSSKRLTGKGRGKGADISLKDATLVAGPEKDKVTIANEMLKAFSIRFVHLNGILFTRTSLETFFDVLASTSSSLREVISLGSAKELTLGIDTSDSALFIVRVVTMLIFSVHNSKKETEGQSYAEIVQRVEPARNSLTASFELLGLVIEKCVQLGDPSSSYFLPGVLVFVEWLACCPDIALGSDPDDRQTAVRNSFWNQFVVFFNQVLSLGPTFIDDVEDETCFSNMSLYDERETENRLALWEDYELRGFLPLLPAQTILNFSRKHSFGTEGPKEKKARIKRIFAAGKALTSVIKVDQNHVYFDSKKKKFLVGVKPADDFLDSHSSPPKACNALQDNQVMIDHNSPIMQLDQQIYMGEEDDDDEVIVFKPLVTEKRKEASDQIYVPSGGFRKSDQVTTMGDFKALSGSDVAFHENQILQARGNASIQVPASVGANLLGPLQPSTQSQAMHMQQVQTQVQVPASVGANLLGLLLTSTQSQAMHMQQVQTQAVNPQPAQSLAASRLQPIQSQVAQPLPSRVVHFQQTQAQVSHVSPAHSQSTSFGGGSKWSPEEAASLASSLSGFAQLGNGHVMRNEMQGNHGVSYYPAHSLPVHQSYNGNGMGGMPYSQSRTPEAVFPPKIDPVLSSGVVADGLGVQSSLAKKNPISRAFRHLGPPPGFNSVPAKLQKEPAPGSELSGNNHLPVDDYSWLDGYQAQSSRGVGLNSSLNYATSGKPEHLGSTGNGLNGPANFPFPGKQVPTSQVQADFPYFQNPQKDNFVDKNHQSTQLPEQYQGQSTWSSRHFV
What is the function of this protein?
Plays multiple roles in growth and development.  Involved in nonsense-mediated mRNA decay (NMD).  May provide a link to the mRNA degradation machinery to initiate NMD and serve as an adapter for UPF proteins function.  Required for meiotic progression through anaphase II of pollen mother cells.  May counteract cyclin-dependent kinase (CDK) activity at the end of meiosis.  May play a role in plant defense through its involvement in NMD.  Together with EXA1, helps to restrict cell death induction during pathogen infection in a salicylic acid- (SA) and reactive oxygen species- (ROS) independent manner (PubMed:29073135).
What are the official names of this protein?
Nonsense-mediated mRNA decay factor SMG7, Protein SMG7, SMG7 homolog.
What are the subcellular locations of this protein?
Cytoplasm, P-body.
Protein: COAX_EHRRG
Sequence: MLIIDIGNTNIKFGICINNQIIQTLRISSQPRRTADEYFFFLNTMRNQLNTNNFTITHIIISSVVPSITKPMIELSTHYFNITPTIINNQHADICNIKIDLNDKLLGSDRLASIIGAVTLYPNKNLLVISMGTATVFNLISKERSIYGQVITPGAHIMAQSMRQHTALLPEISQIKVNKVVHNTLFYAIEAGVYWGYIAMVEGIVKQILHEENKDLHIVATGGNSILFIDHKNFIKNIDPDLTMKGMIYLHNMLFNK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQCE_BACSU
Sequence: MNYWVLALHYNWASSEMVKQAIHLKDCSPEDLQEGIEKKLITAEQYKEITGEAI
What are the official names of this protein?
Uncharacterized protein YqcE.
What is the protein family that this protein belongs to?
To B.subtilis XkdX.
Protein: RL4_STRU0
Sequence: MANVKLFDQTGKEVSSVELNDAIFGIEPNESVVFDVVISQRASLRQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLPQKVRRLALKSVYSAKVAEDKFVAVEGLSFAAPKTAEFAKVLSALSIDSKVLVIVEEGNEFAALSARNLPNVKVATATTASVLDIVNSDKLLVTKEAISTIEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.