PharMolix/UniProtQA huggingface dataset:
Protein: FRPA_NEIMB
Sequence: MNEGEVVLTPEQIQTLRGYASRGDTYGGWRYLANLGDRYADDAAAIVGKDANLNGLNLWMKKGVENLWDDTVGKKTRLEKFDRVALQHFSQYVDLINENNGRLPNTSEIERSYYKAVTENGVSSSAAIDLVINRSLPDMADGYWALGLGIEAERIHNEQAVNNPNGSERDNRKQLISALDKGFDGSFKEKHFTFLQSVIMDVTKLGVEYTIDGWQKIGGWGNGIINDLYKSVVKREWTGIFEIVNNNIKQFRDLFPNPEGWIDDGHQCFAPWVKETKKRNGKYHVYDPLALDLDGDGIETVAAKGFSGSLFDHTNNGIRTATGWVSADDGLLVRDLNGNGIIDNGAELFGDNTKLADGSFAKHGYAALAELDSNGDNIINAADAAFQSLRVWQDLNQDGISQANELRTLEELGIQSLDLAYKDVNKNLGNGNTLAQQGSYTKTDGTTAKMGDLLLAADNLHSRFKDKVELTAEQAKAANLAGIGRLRDLREAAALSGDLANMLKAYSAAETKEAQLALLDNLIHKWAETDSNWGKKSPMRLSTDWTQTANEGIALTPSQVAQLKKNALVSLSDKAKAAIDAARDRIAVLDAYTGQDSNTLYYMSEEDALNIVKVTNDTYDHLAKNIYQNLLFQTRLQPYLNQISFKMENDTFTLDFSGLVQAFNHVKETNPQKAFVDLAEMLAYGELRSWYEGRRLMTDYVEEAKKAGKFEDYQKVLGQETVALLAKTSGTQADDILQNVGFGHNKNVSLYGNDGNDTLIGGAGNDYLEGGSGSDTYVFGEGFGQDTVYNYDYATGRKDIIRFTDGITADMLTFTREGNHLLIKAKDGSGQVTVQSYFQNDGSGAYRIDEIHFDNGKVLDVATVKELVQQSTDGSDRLYAYQSGNTLNGGLGDDYLYGADGDDLLNGDAGNDSIYSGNGNDTLDGGEGNDALYGYNGNDALNGGEGNDHLNGEDGNDTLIGGAGNDYLEGGSGSDTYVFGKGFGQDAVYNYDYATGRKDIIRFTDGITADMLTFTREGNHLLIKAKDGSGQVTVQSYFQNDGSGAYRIDEIHFDNGKVLDVATVKELVQQSTDGSDRLYAYQSGNTLNGGLGDDYLYGADGDDLLNGDAGNDSIYSGNGNDTLDGGEGNDALYGYNGNDALNGGEGNDHLNGEDGNDTLIGGAGNDYLEGGSGSDTYVFGEGFGQDTVYNYHVDKNSDTMHFKGFKAADVHFIRSGSDLVLSASEQDNVRISGFFYGENHRVDTFVFDDAAISNPDFAKYINAGNNLVQSMSVFGSNTAATGGNVDANIQSVQQPLLVTPSA
What is the function of this protein?
May participate in the pathogenesis of meningococcal disease.
What are the official names of this protein?
Iron-regulated protein FrpA.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Secreted.
Protein: CTGE8_HUMAN
Sequence: MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF
What are the official names of this protein?
cTAGE family member 8, Protein cTAGE-8.
What is the protein family that this protein belongs to?
Belongs to the cTAGE family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LEUC_MICAN
Sequence: MSARTLFDKVWDAHTVKILPSGQTQLFIGLHLVHEVTSPQAFSMLRERGLKVLFPRRTIATVDHIVPTENQARPFLDDLAEEMIRAIETNVQTNHIPFYGIGSGNQGIVHVIAPEQGLTQPGMTIACGDSHTSTHGAFGAIAFGIGTSQVRDVLATQTLSLSKLKVRRVEVNGDLNPGVYAKDVILHIIRQLGVKGGVGYAYEYAGSTIERMSMEERMTICNMAIEGGARCGYINPDQITYDYLKGRDFAPKDWESAVNWWESIKSDADAVYDDVVVFDAGEIEPTVTWGITPGQGIGVNEVIPTPESLPASERAIAEEAYQYMKLTPGAPIKGTKIDVCFVGSCTNGRISDLREAAKFAQGHRVAPHVKAFIVPGSERVKKQAEAEGLDQIFLASGFEWREAGCSMCLAMNPDKLQGDQISASSSNRNFKGRQGSASGRTLLMSPAMVVAAAIKGEVTDPRELLN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RS15_MYCBO
Sequence: MALTAEQKKEILRSYGLHETDTGSPEAQIALLTKRIADLTEHLKVHKHDHHSRRGLLLLVGRRRRLIKYISQIDVERYRSLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: METK_ALKOO
Sequence: MFKKLFTSESVTEGHPDKMCDQISDAILDAILEKDPAARVACETSVSTGLVLVAGEITTKCYVDIPKIVRKTIEEIGYTRAKYGFDSDTCAVLTAINEQSADIALGVDEALESKKGEHRDELEAIGAGDQGIMFGFACNETPELMPLPISLAHKLAKRLSDVRKDGTIGYLRPDGKTQVTVEYDGDKPVRVDTIVISTQHGPEVDAATIEKDMIEHVVQKIVPAELLDENTRYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAGLADKCEIELAYAIGVSRPISILVETFGTGKIAEADIAELIGKHFDLRPAAIIRDLGLRNPGYRNVAAYGHFGRADLDLTWERTDKAELLRKEAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOC2_STAAW
Sequence: MHSAKLIDHTLLKPESTRTQIDQIIDEAKAYHFKSVCVNPTHVKYAAERLADSEVLVCTVIGFPLGASTTATKAFETEDAIQNGADEIDMVINIGALKDGRFDDVQQDIEAVVKAAKGHTVKVIIETVLLDHDEIVKASELTKAAGADFVKTSTGFAGGGATAEDVKLMKDTVGADVEVKASGGVRNLEDFNKMVEAGATRIGASAGVQIMQGLEADSDY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase 2, DERA 2, 2-deoxy-D-ribose 5-phosphate aldolase 2, Phosphodeoxyriboaldolase 2, Deoxyriboaldolase 2.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_ENCCU
Sequence: MTAASEKTTRRFTIDCTKPASDSLISPSDLGAFLQQKIKCYTGKKEKLLHINANGNIVEVDVTGGFIGKQGLKWQIGRFLHMKKLRAFIKIFAQGLDGFELRYINVEEGKEE
What are the official names of this protein?
60S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL22 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPB_CHLT3
Sequence: MTEPLIFEKSKSGRKGYTLPKCDVPVQEVSELIPAQFLRKAKADLPEVQENEVVRHFVKLSTLNHHVDKGMYPLGSCTMKYNPKVNEVTSALPGFSALHPLQPQESVQGALKLMYELQEWLKEICGMKAVSLQPVAGAHGELTGILLIRKYHEKQGKPRKKILVPDSAHGTNPASSAIAGYMTVGVKTNARGLTDMDDLRAKLDEDVAALMLTNPNTLGIFESQILEISELLHANGSLLYMDGANMNALLGITRPGDMGFDVVHYNLHKTFSTPHGGGGPGSGPVGVSEKLVEFLPTPAIEKKESGEKTSYCLNYDLPDSIGKMSGFYGNFSIMVRAYTYLLMHGAKGLRAVSENAIINATYLLSRLRGKFDVPYDEQIMHEFCLSGERQKTNGVKTLDMAKRLLDFGFHAPTIYFPLIVKECMMIEPTESETKETLDDFADVMLRIAEEAESNPEMVLNAPHNTPVKRLDDAYASRNINIKYTPKEKETVEA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: THIM_RHIL3
Sequence: MQTRTTPGAMLKAMREKPPLVQCITNYVAMNIAANVLLAAGASPAMVHAAEEAGEFAAIASALTINIGTLSTQWIDGMQAAAKAATSAGKPWVLDPVAHYATAFRRNAVAELLALKPTIIRGNASEIIALAGGESRGQGVDSRDPVEQAEGSARWLAERQRAVVAVTGAVDFVTDGERAVRIEGGSALMPQVTALGCSLTCLVGAFAATAPEDIFGATVAALSTFAIAGEEAALGAAGPGSFSWRFLDALAALDAETLDARARISAA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: YRAJ_BACSU
Sequence: MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRSGPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSDTYVYTGSDGPVGYKCN
What are the official names of this protein?
Uncharacterized protein YraJ.
What is the protein family that this protein belongs to?
To B.subtilis YraI.
Protein: NU5M_PODAN
Sequence: MYLSIIILPLLGCIVSGFLGRKVGVKGAQLITCSNVVITTILSILAFIEVGFNNIPVTINLFRWIDSEWFNIIWGFQFDSLTVSMLIPVLIISSLVHIYSISYMSSDPHNQRFFSYLSLFTFMMIILVTANNYLLMFVGWEGVGVCSYLLVSFWFTRIAANQSSISAFLANRVGDCFLTIGMFAILWSLGNLDYSTVFSLAPYINSKVVLIIGICLLIGAMAKSSQVGLHVWLPMAMEGPTPVSALIHAATMVTAGVYLLMRSSPLIEYNSTVLLLCLWLGAITTVFSSLIGLFQQDIKKVIAYSTMSQLGMMVIAIGLSSYNVALFHLINHAFYKALLFLGAGSVIHAVADNQDFRKYGGLINFLPLTYSVMLIASLSLVAFPFMTGFYSKDFILESAYGQFSFSGVAVYIIATIGAIFTTLYSVKVLYLTFLSNPNGTRAYYNYKPALEGDLFLTLPLIILAIFSIFFGFITKDIFIGLGSNFFGDNSLFIHPTHEIMIDTEFAVPVLFKLLPFIFTISFSIIALTISEFLSELVIYFKLSRLGYNIFGFFNQRFLIELFYNKYITNLILDLGGQMTKILDKGSIELFGPFGLEKGLVNFSKNISSLSTSHVTTYALYILVAFILYLLYNYLSFNFLPFLIAGLTILTTI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SYV_CHLFF
Sequence: MEEDVFPKAYDPKGLEDKLYAFWEDAGMFTAQSASNKPPYAIIMPPPNVTGILHMGHALVNTLQDVLIRYKRMSGFEVCWVPGTDHAGIATQTVVERHLYSSLGKRRIDFSREEFLEYVWEWKEKSEGIILSQLRQLGCSCDWSRLRFTMEPLASRAVKKAFKVLFDRGHIYRGYYLVNWDPVLQTALADDEVEYEEKDGWLYYIRYRVVDSSDEIIVATTRPETLLGDTAIAISPDDERYSHLLGAKVHLPFVDREIPIIGDMSVDPLFGTGAVKITPAHDRDDYRTGINHNLPLVNILTPTGKINENGGIFAGLSKEKARDDIITALDAMGLFVKKEPYTLRVGVSYRSGAVIEPYLSKQWFVSVDSFRDSLREFVASDSIKIFPPEFTRNYLSWVNNLRDWCISRQLWWGHRIPVWYHKSDEDRIICYDGEGLPEEVAQDPDSWDQDPDVLDTWFSSGLWPLTCLGWPDVEAKDLKKFYPTSVLITGHDILFFWVTRMVLLCSAMVGEKPFSDVFLHGLIFGKSYKRYNNLGEWTYISGEEKHAYDMGKPLPKDVTAKWEKLSKSKGNVIDPLEMIDKYGADAVRMALCSCANRGEQIDLDYRLFEEYKNFANKIWNGARFIFGHISNLTGKDLADGINQNLLGLEDYYILDGFNRLLKELESAYQSYAFDRVTTMAYEFFRNDFCSTYIEIIKPTLYGKQGNDEDRLTKQKLLAVLLVNILGVLHPIAPFVTETLFLKLKEAIGVIVDASSDEITAHALNMLRADSYVLAPYPQAMRITIPDNLHASFALAERLVYTIRNIRGEMQLDPRASLEAFVICPEGVSVDTYVPMMCALGGLSSVEHLTEEPKDRVYSLGVVEGIRLGVFVPIEQITKEKNRLEKEKIRLEKAIESVSRLLGSENFRAKANPDLVSAKEEALKNNRMELQSILDKLASFS
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSD_DICLA
Sequence: MNGTEGPFFYVPMVNTTGIVRSPYDYPQYYLVSPAAYAALGAYMFLLILLGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNMEGFFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFGENHAIMGLAFTWVMACSCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFACHFIIPMCVVFFCYGRLLCAVKEAAAAQQESETTQRAEKEVTRMVVIMGIAFLICWCPYASVAWYIFTHQGSEFGPVFMTLPAFFAKTSSVYNPLIYILMNKQFRHCMITTLCCGKNPFEEEEGASTASKTEASSVSSSSVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (PubMed:18422881).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: DNBI_HHV8P
Sequence: MALKGPQTLEENIGSAAPTGPCGYLYAYVTHNFPIGEASLLGNGYPEAKVFSLPLLHGLTVESDFPLNVKAVHKKIDATTASVKLTSYHREAIVFHNTHLFQPIFQGKGLEKLCRESRELFGFSTFVEQQHKGTLWSPEACPQLPCANEIFMAVIVTEGFKERLYGGKLVPVPSQTTPVHIGEHQAFKIPLYDEDLFGPSRAQELCRFYNPDISRYLHDSIFTGIAQALRVKDVSTVIQASERQFVHDQYKIPKLVQAKDFPQCASRGTDGSTLMVIDSLVAELGMSYGLSFIEGPQDSCEVLNYDTWPIFENCETPDARLRALEVWHAEQALHIGAQLFAANSVLYLTRVAKLPQKNQRGDANMYNSFYLQHGLGYLSEATVKENGASAFKGVPVSALDGSSYTLQHLAYASSFSPHLLARMCYYLQFLPHHKNTNSQSYNVVDYVGTAAPSQMCDLCQGQCPAVCINTLFYRMKDRFPPVLSNVKRDPYVITGTAGTYNDLEILGNFATFREREEEGNPVEDAPKYTYWQLCQNITEKLASMGISEGGDALRTLIVDIPSFVKVFKGIDSTVEAELLKFINCMIKNNYNFRENIKSVHHILQFACNVYWQAPCPVFLTLYYKSLLTVIQDICLTSCMMYEQDNPAVGIVPSEWLKMHFQTMWTNFKGACFDKGAITGGELKIVHQSMFCDLFDTDAAIGGMFAPARMQVRIARAMLMVPKTIKIKNRIIFSNSTGAESIQAGFMKPASQRDSYIVGGPYMKFLNALHKTLFPSTKTSALYLWHKIGQTTKNPILPGVSGEHLTELCNYVKASSQAFEEINVLDLVPDTLTSYAKIKLNSSILRACGQTQFYATTLSCLSPVTQLVPAEEYPHVLGPVGLSSPDEYRVKVAGRSVTIVQSTLKQAVSTNGRLRPIITVPLVVNKYTGSNGNTNVFHCANLGYFSGRGVDRNLRPESVPFKKNNVSSMLRKRHVIMTPLVDRLVKRIVGINSGEFEAEAVKRSVQNVLEDRDNPNLPKTVVLELVKHLGSSCASLTEEDVIYYLGPYAVLGDEVLSLLSTVGQAGVPWTAEGVASVIQDIIDDCELQFVGPEEPCLIQGQSVVEELFPSPGVPSLTVGKKRKIASLLSDLDL
What is the function of this protein?
Plays several crucial roles in viral infection.  Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein.  May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.  Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle.  Can also catalyze the renaturation of complementary single strands.  Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments.  This process is driven by the protein which can form double-helical filaments in the absence of DNA.
What are the official names of this protein?
Major DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae major DNA-binding protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=In the absence of DNA replication, found in the nuclear framework- associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).
Protein: C1D_PONAB
Sequence: MAGEEINEDYPVEIHEYLSAFENSIGAVDEMLKTMMSVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFVKNALWEPKPKNASKVANKGKSKS
What is the function of this protein?
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5. 8S rRNA.  Forms a multi-subunit complex with MPHOSPH6 and EXOSC10 and this complex along with MTR4 is required for the 3'-5' end processing of the 5. 8S rRNA.  Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA.  Can induce apoptosis in a p53/TP53 dependent manner.  May regulate the TRAX/TSN complex formation.  Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
What are the official names of this protein?
Nuclear nucleic acid-binding protein C1D.
What is the protein family that this protein belongs to?
Belongs to the C1D family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization. Colocalizes with TSNAX in the nucleus.
Protein: HSPB3_RAT
Sequence: MAKIILRHLIETPVRYQEEFEARGLEDCRLDHALYALPGPTIEDLRKARGTPKALAEDSDSAETPPGEGKSRFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVETKDLSAILCHDGILVVEVKDPLETK
What is the function of this protein?
Inhibitor of actin polymerization.
What are the official names of this protein?
Heat shock protein beta-3, HspB3.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.
Protein: VG79_ICHVA
Sequence: MDFECGSLVTDGERVSNPTDRGFRWSAAPRGMLKPSGWRADGGVWFCDVTLDYDTIVAHGTLQDDNLVFMTRLYFGPKGGLIPDDVKSDRHVCPDCGVKVIRFTLVDDFLDEHVYHSRGGCPRIRQFLGQRVLSEYYELTQFLKGDRPYPARRKWDLSRDSAVLKAYAVYASPKDNSVQTG
What are the official names of this protein?
Uncharacterized protein ORF79.
Protein: BTUB_VIBCH
Sequence: MQKSALAIALASLLTPISYLHANEAQPQETVVVTANRFEQKASSTLADVEIITRQDIEQTQAKTLPELLRRLTGVQITQNGGRGQLASLFVRGTSSDQVLVLVDGIRFARAAKGAVDFNQIPLTYVDRIEYVRGARASLYGSEAIGGVINIITKARSQQQGTTVSAGLGSLDYQELSIASGVAIGEKGQMNVALGTESDKGYNVRPVPGVNDGDRHGFRSDNALLGYVHQFDESWSLFANARAYENIYQYDNSYGTRDYKEAEKDDLSFTIGTQYQSERWVSELQLTTQKQKSWDYTQSKGKYSDTSDNLEQRNIQWINRYLVNDVWTFAGGVDWRDESYIDKTADKEFDRSNTAAFAVVAAEWQQWLLEASLRFDDNQEYGSQTTHNIALGYQFIPEFGVKASYGSAFKAPNLYQQYDPSYGNVNLQPEDADSAELSFYGLFSGIKWSITGYDYKINNLIDYNSTTKNYQNVIGESNIKGVEFTAEFATGIVQHQLSVDLKDADDSKGKTLQRRAEHMYKWNALVAFEQVDWSIGYQYVGKRPDLDYNTYPTQNITLDAYSLVDTSVSYYVTDSTTISARIDNLLDKEYETANGYPAAERAYYLNIGYQF
What is the function of this protein?
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space.  It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
What are the official names of this protein?
Vitamin B12 transporter BtuB, Cobalamin receptor, Outer membrane cobalamin translocator.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: ADRA2_LABOS
Sequence: MDPLNATGMDAFTAIHLNASWSADSGYSLAAIASIAALVSFLILFTVVGNILVVIAVLTSRALKAPQNLFLVSLATADILVATLVMPFSLANELMGYWYFGKVWCGIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPKRVKCIIVIVWLISAFISSPPLLSIDSNNYISSQPQCMLNDDTWYILSSSMASFFAPCLIMILVYIRIYQVAKTRTRSMSGKEPRPDGVTQTENGLNKANSPCHGDRENGHCQCPPTPSQRTVTIGQQTDDADMDESFSSEGKGHKPQRQDSQRAKRPGLKKSSISKQSARISRVSNKSVDLFASRRKRRRSSIAEKKVSQAREKRFTFVLAVVMGVFVVCWFPFFFSYSLHAVCRDYCKIPDTLFKFFWIGYCNSSLNPAIYTIFNRDFRRAFQKILCKSWKKSF
What is the function of this protein?
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
What are the official names of this protein?
Alpha-2 adrenergic receptor, Alpha-2 adrenoreceptor, Alpha-2 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HDFR_SALTY
Sequence: MDTELLKTFLEVSRTRHFGRAAEALYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTTAGEKLLPYAETLMNTWQAARKEVAHTSRHNEFSIGASASLWECMLNAWLGRLYQLQEPQSGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGHFTLALYCSSPARKKSELNYLRLEWGPDFQQHETGLIAADEVPVLTTSSAELARQQLSALNGCSWLPVNWANEKGGLHTVADSATLSRPLYAIWLQNSDKYSLICDLLKTDVLDEQ
What is the function of this protein?
Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
What are the official names of this protein?
HTH-type transcriptional regulator HdfR, H-NS-dependent flhDC regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: QRT3_ARATH
Sequence: MELRKSQVAMPVFLAIMSLMVSQVVFAEKDSGSMSPHDRALAEMQALKASLVRRNLPALVSPPPTPPQAVPGPRVYQVISYGADPTGKLDSTDAILKAMEEAFDGPNHGVLMQGINDLGGARIDLQGGSYLISRPLRFPSAGAGNLLISGGTLRASNDFPVDRYLIELKDESSKLQYIFEYITLRDLLIDCNYRGGAIAVINSLRTSIDNCYITRFGDTNGILVKSGHETYIRNSFLGQHITAGGDRGERSFSGTAINLMGNDNAVTDTVIFSARIGVMVSGQANLLSGVHCYNKATGFGGTGIYLRLPGLTQNRIVNSYLDYTGIVAEDPVQLQISGTFFLGDAFILLKSIAGYIRGVSIVDNMFSGSGHGVQIVQLDQRNTAFDDVGQVVVDRNSVNGMVEKSTVARGSVDGNGTSWTVDFNPVLLFPDLINHVQYTLVASEAGVFPLHALRNVSDNRVVVETNAPVTGTVYVTVNQGV
What is the function of this protein?
Polygalacturonase required for degrading the pollen mother cell wall during microspore development.
What are the official names of this protein?
Polygalacturonase QRT3, AtQRT3, PG QRT3, Pectinase QRT3, Protein QUARTET 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
Protein: FLII_AGRFC
Sequence: MTMPESMLSESKLSGWAISPKLAQLASLAGHYADPEFSVAHGGHVRTIAAGHYTVSGLSRHVRLGEFVAHRSATGIHLGEVVRVEPDICYVCPIEPGEPIGIHDTVIRKGAFRVSPDESWCGRTINALGEPIDGQGPLASGIVRRSISNNAPPSMTRKRVETPFKTGVRAIDIFSPLCLGQRLGIFAGSGVGKSTLLSMLAKADAFDKVVIALVGERGREVREFIEDTMGDNMSKSVAVVATSDESPMLRKMAPLSAVTIAEHFRDQGDNVLLIIDSVTRFAHAIREVAVASGEPPVARGYPASVFTELPRLLERAGPGAEGTGTITAIVSILVDGDNHNDPIADSTRGILDGHIVLDRSLAEEGRYPPINPLASISRLAKKAWTPDQEKLVSRLKALVHRFEETRDLRLIGGYRPGTDPDLDMAVKQVPIIYETLKQLPDEPAAQDAYADLATALRGGAQNGQPQVNPRMRG
What is the function of this protein?
Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.
What are the official names of this protein?
Flagellum-specific ATP synthase.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_SYNWW
Sequence: MKVLVVNAGSSSIKYQVVDMTDESVLAVGLVDRVGIPGTTLDHSPLGKDKVTIKKDLPDHTAGMELVLQVLVNEEYGCIKSMDEIGAVGHRVVHGGEGFAESVVIDDEVKRVIKECFEIAPLHNPPNMMGIEACQRLMPNVKHVAVFDTAFHQTMGPANFMYALPYDVYEKFRVRRYGFHGTSHFYVAHRAAEMLGKPYEECKIITLHLGNGASMAAIKDGKVIDTSMGFTPLEGLVMGTRSGDIDPAIVFFLMDKLGMNSSEANNYFNKKSGMLGLSGVSNDLRDILEAAGSGNERAKIALDVYYNKVKGYIGNYIAKLNGVDCLVFTAGVGENAIDIRENVCANLDYLGIKMDVEKNKVRGKEVDVATADSKVRIFLIPTNEELVIARDTFNLAK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF6_NITMS
Sequence: MDIIKFDVYRGPNIGVYISVNDNTILLPMGFAKTKAEKLAKYLGVNYLFTSIANTRLIGALCIMNNKGILLPKTAYQNEFDFLKKELDLEVGVLDSKLTALGNVICANDKGAVVSPWLSKEDCQTISDVLGVETIQKKIAGFNQTGVVMVANNSGAAIHPEADEEDMKTFSNLLGVKIEQSSINNGIPYVSSGILANNNCIIVGSLTTGPEIMMLTRAFLN
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.