PharMolix/UniProtQA huggingface dataset:
Protein: KCS16_ARATH
Sequence: MDYPMKKVKIFFNYLMAHRFKLCFLPLMVAIAVEASRLSTQDLQNFYLYLQNNHTSLTMFFLYLALGSTLYLMTRPKPVYLVDFSCYLPPSHLKASTQRIMQHVRLVREAGAWKQESDYLMDFCEKILERSGLGQETYVPEGLQTLPLQQNLAVSRIETEEVIIGAVDNLFRNTGISPSDIGILVVNSSTFNPTPSLSSILVNKFKLRDNIKSLNLGGMGCSAGVIAIDAAKSLLQVHRNTYALVVSTENITQNLYMGNNKSMLVTNCLFRIGGAAILLSNRSIDRKRAKYELVHTVRVHTGADDRSYECATQEEDEDGIVGVSLSKNLPMVAARTLKINIATLGPLVLPISEKFHFFVRFVKKKFLNPKLKHYIPDFKLAFEHFCIHAGGRALIDEMEKNLHLTPLDVEASRMTLHRFGNTSSSSIWYELAYTEAKGRMTKGDRIWQIALGSGFKCNSSVWVALRNVKPSTNNPWEQCLHKYPVEIDIDLKE
What are the official names of this protein?
3-ketoacyl-CoA synthase 16, KCS-16, Very long-chain fatty acid condensing enzyme 16, VLCFA condensing enzyme 16.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DNAK_CHLTR
Sequence: MSEKRKSNKIIGIDLGTTNSCVSVMEGGQPKVIASSEGTRTTPSIVAFKGGETLVGIPAKRQAVTNPEKTLASTKRFIGRKFSEVESEIKTVPYKVAPNSKGDAVFDVEQKLYTPEEIGAQILMKMKETAEAYLGETVTEAVITVPAYFNDSQRASTKDAGRIAGLDVKRIIPEPTAAALAYGIDKEGDKKIAVFDLGGGTFDISILEIGDGVFEVLSTNGDTHLGGDDFDGVIINWMLDEFKKQEGIDLSKDNMALQRLKDAAEKAKIELSGVSSTEINQPFITIDANGPKHLALTLTRAQFEHLASSLIERTKQPCAQALKDAKLSASDIDDVLLVGGMSRMPAVQAVVKEIFGKEPNKGVNPDEVVAIGAAIQGGVLGGEVKDVLLLDVIPLSLGIETLGGVMTPLVERNTTIPTQKKQIFSTAADNQPAVTIVVLQGERPMAKDNKEIGRFDLTDIPPAPRGHPQIEVTFDIDANGILHVSAKDAASGREQKIRIEASSGLKEDEIQQMIRDAELHKEEDKQRKEASDVKNEADGMIFRAEKAVKDYHDKIPAELVKEIEEHIEKVRQAIKEDASTTAIKAASDELSTHMQKIGEAMQAQSASAAASSAANAQGGPNINSEDLKKHSFSTRPPAGGSASSTDNIEDADVEIVDKPE
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, 75 kDa membrane protein, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: VP1_POVM3
Sequence: MAPKRKSGVSKCETKCTKACPRPAPVPKLLIKGGMEVLDLVTGPDSVTEIEAFLNPRMGQPPTPESLTEGGQYYGWSRGINLATSDTEDSPENNTLPTWSMAKLQLPMLNEDLTCDTLQMWEAVSVKTEVVGSGSLLDVHGFNKPTDTVNTKVISTPVEGSQYHVFAVGGEPLDLQGLVTDARTKYKEEGVVTIKTITKKDMVNKDQVLNPISKAKLDKDGMYPVEIWHPDPAKNENTRYFGNYTGGTTTPPVLQFTNTLTTVLLDENGVGPLCKGEGLYLSCVDIMGRRVTRNYDVHHWRGLPRYFKITLRKRWVKNPYPMASLISSLFNNMLPQVQGQPMEGENTQVEEVRVYDGTEPVPGDPDMTRYVDRFGKTKTVFPGN
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins.  Interacts with terminal alpha(2,3)-linked sialic acids on the cell surface to provide virion attachment to target cell.  This attachment induces virion internalization predominantly through caveolin-mediated endocytosis.  Once attached, the virion is internalized by caveolin-mediated endocytosis and traffics to the endoplasmic reticulum.  Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating.  Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal.  In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA.
What are the official names of this protein?
Major capsid protein VP1, Major structural protein VP1.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses coat protein VP1 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RN146_PONAB
Sequence: MAGCGEIDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYGERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVSAQSGASVQPLVSSVRPLTSVDGQLTSPATPSPDASTSLEDSFAHLQLSGDNTAERSHRGEGEEDHESPSSGRVPAPDTSIEETESDASSDSEDVSAVVAQHSLTQQRLLVSNANQTVPDRSDRSGTDRSVAGGGTVSVSVRSRRPDGQCTVTEV
What is the function of this protein?
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation.  May regulate many important biological processes, such as cell survival and DNA damage response.  Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex.  Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2.  Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation.  Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'.  May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location.  Neuroprotective protein (By similarity).  Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity).  Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity).  Does not affect PARP1 activation.  Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity).  Promotes cell survival after gamma-irradiation.  Facilitates DNA repair (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF146, Iduna, RING finger protein 146, RING-type E3 ubiquitin transferase RNF146.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding (By similarity).
Protein: MFRN1_MOUSE
Sequence: MELRRGGVGNQAAGRRMDGDCRDGGCGSKDAGSEDYENLPTSASVSTHMTAGAMAGILEHSIMYPVDSVKTRMQSLNPDPKARYTSIYGALKRIMHTEGFWRPLRGLNVMMMGAGPAHAMYFACYENMKRTLNDVFSHQGNSHLANGVAGSMATLLHDAVMNPAEVVKQRLQMYNSQHQSAFSCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPRRDYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENMALSLANVSGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYILTKRQLENRTLY
What is the function of this protein?
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.
What are the official names of this protein?
Mitoferrin-1, Mitochondrial iron transporter 1, Mitochondrial solute carrier protein, Solute carrier family 25 member 37.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PTH_THEON
Sequence: MFRYKQVMVIRKDLKLSKGKMAVQVAHGAVTAALKVQKEKPEWFKAWFHEGQKKVVVKAENERELFELKAHAEKLGIPTALIRDAGLTEIPPGTITCLAVGPAPEELVDKVTGHLKLV
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDHBB_DANRE
Sequence: MASVLQKLITPLFSGPLEPPRNKVTVVGVGQVGMACAVSVLLRELADELALVDVVEDKLKGEMMDLQHGSLFLKTPKIVSGKDYSVTANSRIVVVTAGVRQQEGESRLNLVQRNVNIFKHIIPQIVKYSPNCILIVVSNPVDVLTYVTWKLSGLPKHRVIGSGTNLDSARFRYLMAERLGIHPSSFNGWILGEHGDSSVPVWSGANVAGVSLQKLNPDIGKDTDRENWKETHKKVVDSAYEVIRLKGYTNWAIGLSVADLTESIMKNLNRVHPVSTMVKGMYGISDEVYLSLPCVLNSAGVGSVVNMTLTVDEVSQLKKSADMLWHIQRDLRDL
What are the official names of this protein?
L-lactate dehydrogenase B-B chain, LDH-B-B.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_BIFLS
Sequence: MIKVSVVGAKGRMGSHVVEAVNKAEDTQLALALDADDDLTQVTTDNTDVVVEFTVPSVSLNNVLTLIGQGVDVVVGTTGWTDEKLTQVKSAIANGPKPETQKVFIAPNFAISAVLADYFATKAARYFESAEVIELHHPTKVDAPSGTAIHTAHGIAEARKAAGLAPVPDATETDGGSRGQVVDGIHVHAVRLRGLNAHEEVLFGNAGEQLTIRADSFDRTSFMPGVLLAVRKLAGDAPAGLTIGLDHFLDL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIVIB_ENTF6
Sequence: MWKISNENDIFKKRKPLPPKKSEESQPELTPWQKQNQEYLKKQAEEAASKGENEQAEVTITLQEQSQEEPQQHLPQETVEEEEHFADRLPNVKKTRNKRLYRRLAFILTCLGTAILVALYFVSPLSRLSEVTVSGNKSVESQAIIQQSKLETGSGLWEQYSNRNYFSANIQKKFPIIKKANIKLNGINSFKIDIQEYQIVALAATKGGYHPILENGKTLAETTKAAESGKPIFENFKEDKLIPELMASYNKLPQEIKQGISEIKYAPSKTNKDLINVYMNDGNRVIVNISDLSEKMAYYSQVAEQMDKPGIVDMEVGIFSYPYEKESEETGSEVSEDSAVENQEVVDPNAGVATDGANNGTPTNGENQEVQQAE
What is the function of this protein?
Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.
What are the official names of this protein?
Cell division protein DivIB.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. DivIB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: DNAA_SALA4
Sequence: MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNTFCGADAPQLRFEVGTKPVTQTLKTPVHNVVAPAQTTTAQPQRVAPAARSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKIADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2B_HALSA
Sequence: MDYEEQLDRAMDEKPDVTGSETRFEVPDPNVRKEGNVTVYENFQATLDALSRTQDHVLKFLQNEVGTSASIDESGRARLTGEFGQRRVSDTLDAYVETYVTCPECGLPDTNLETDGDTIQLHCEACGARSTV
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit beta, aIF2-beta, eIF-2-beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: CHA4_YEAST
Sequence: MMLEPSPPPLTTTVTPSLPSSLKKSVTDNDQNNNNVPRKRKLACQNCRRRRRKCNMEKPCSNCIKFRTECVFTQQDLRNKRYSTTYVEALQSQIRSLKEQLQILSSSSSTIASNALSSLKNNSDHGDAPNEKILKYGETAQSALPSSESNDENESDAFTKKMPSESPPPVGTNSIYPSNSLSIIKKKTDGSTRYQQQQVSLKNLSRSPLILRSLSLFFKWLYPGHYLFIHRETFLSAFFGDTNTKSYYCSEELVFAIAALGSLISYKSETELFQQSEVFYQRAKTIVLKKIFQLEDSSLAESSSSSKLAIIQTLLCLAFYDIGSGENPMAWYLSGLAFRIAHEIGLHLNPEAWSNVYEDELSIMDFEVRSRIYWGCYIADHLIAILFGRSTSLRLSNSTVPETDELPEIETGIEEYIYDPKVILSTANPLKKLIVLSRITEIFASKIFSPNETLLQRSEYLAKFNLEVYNWRRDLPPELQWTKRSLMEMTDFNPTIAYVWFHYYIVLISYNKPFIYEIKQSRELVEGYVDELYYLLKVWKNKFKTFEKATIYMIYSAILAIQCMKSNLIKKDRKQDFLNFLSAPTLNYELARKFIENSEDALHNSETMDLLGTLSHGNDFALEYNFDFTLLNEIDMLIGGNTNDGLSK
What is the function of this protein?
Activates the CHA1 gene for L-serine dehydratase.  Binds to the DNA sequence 5'-GVGGARAYRTRATTCCRC-3'.
What are the official names of this protein?
Activatory protein CHA4.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y994_METTH
Sequence: MNMLVVENGTILRGPELTPQRKNLVIEDGIIKEITDERAPSGERIDASKLMVCPALVNSHVHIGDSVALDVGDGRPLEDIVRPPNGLKHRILESSPPGMLMEAMRNSARDMITHGIGSFIDYREGGPEGVELLREAIGDLPISGIILGRDPVVFDQEASRAEIRRRVRGVLRVSDGFAPSGMGEITDETASIIVEECERAGKIASIHVAEHRESQRRSLEDTGMSEVERALNAGFKLLVHLTNPVREDLKLVRESGASVVLCPRSNGALSSGIPPIRRMHELGINLLLGTDNLMFNSPDMLREMEYTLKVTRGCARRYFPPVEVLRMATSNTSAFTGTGVIEEGFPADLILVEKLSGDPYLSIINRTESKNIIYLIIKGKLVKR
What are the official names of this protein?
Putative aminohydrolase MTH_994.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
Protein: Y4OM_SINFN
Sequence: MTKESKPDRLRQMGALNPKPESVRAPWFREAGFFDPLDLVQVKYEMLRHAREDGTNKADAAALFGLSRQTYYQAEAAFERDGMSGLLPRTRGPKSAHKLTGEVMRLVEEHLDANGQLQARSLADLVHSRLGISVHPRSIERAVARKKKR
What are the official names of this protein?
Uncharacterized protein y4oM.
Protein: CH60_TSUPA
Sequence: MAKTIAFDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNMAAGANPLGLKRGIEKAVEAVTEHLLKEAKEVETKEQIAATAGISAGDPAIGELIAEAMDKVGKEGVITVEESNTFGLQLELTEGMRFDKGFISGYFATDAERQEAVLEDAYILLVSSKISTVKDLLPLLEKVIQSGKPLAIIAEDVEGEALSTLIVNKIRGTFKSVAIKAPGFGDRRKAMLQDMAILTGGQVISEEVGLSLETAGLELLGQARQVVVTKDETTIVDGAGSKEQIEGRVSQIRAEIESSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGAALAQSGKVFETLNLEGDEATGANIVKVALDAPVKQIAINAGLEPGVVAEKVRNSPAGTGLNAATGVYEDLLAAGINDPVKVTRSALQNASSIAALFLTTEAVVADKPEKAGAPVDPTGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60, Heat shock protein 60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELO_SHEFN
Sequence: MQFKQDFFEQLEGFYSQVYPLPISNPHWLGWSDDAAQLIGLEKPNAELLMQLSANYAAPGASYYAQVYSGHQFGGYTPRLGDGRSIILGEAIGPNGAWDVALKGGGPTPYSRQGDGRAVMRSAVREFLVSEALAALNVPTSRALAVIGSDLPVWRESQETAAITVRLAKSHIRFGHFEYFFHSEQGDAAKLTQLVNFTIQQHFPHLSTDAAGYKQWFYEVVQSTAKMIAHWQSVGFAHGVMNTDNMSILGDTFDFGPFAFLDTFKEGFICNHSDHEGRYAFGQQPGIGLWNLKRLAQTLTPIIESDDLIAALNTYQFELVQQYLLLMRAKLGFSQPNQSPNAINAEEQADLGNKDLQLVGQLTGLLETNQLDYTNSLRRFGQLDPSSAHSSLRDDMVDLAGFDTWYQAYQSRVGEVADVNAWQCERNSANPKYILRNYLAQEAIIAIEENGDNSKLLQLQQLLQRPFDEQSEMEDFAKRPPQWGQGLIMSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: YCIZ_SALPA
Sequence: MSDIEAQRIAARIDTVLDILVAGDYHSAINNLEILRAELLDQVKDGISPSQAPGSPWEI
What are the official names of this protein?
UPF0509 protein YciZ.
What is the protein family that this protein belongs to?
Belongs to the UPF0509 family.
Protein: CTAA_RICRS
Sequence: MQKSLITKWLCINCIMVIATIVIGGITRLTGSGLSIVEWRPVTGILPPFSFESWQSEFAKYKAFPEYNSVNYGITLSQFKFIYLLEFIHRLLGRITALIYIVPVIYFYFKDVIKNRDMLPYIIALLLFCVQGFIGWYMVKSGLLNSPYVSHFRLAFHLIIAVIIYHILFYQLIKNRCDILLIPSQTDFKLPLIFSGIAITVVYVQIFLGALVAGLDAGLIYNSFPLMDDRFIPMEIKDNFFDLKNWYDPVFIQFIHRLVGYSVFLVVVVLIICLLKIEHPKLNKIAYFLMIALFMQVSTGIITLLYSVPIIIASIHQLFAIILLSVIIWCYFLIKSF
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ILVD_CAMJD
Sequence: MRSDAIKKGHLKAPNRSLLRACGLKDEDFDKPFIGVANSYIDIIPGHYFLNDYAKIIKDEIRKNGCVPFEFNTIGIDDGIAMGHEGMLYSLPSREIIANSIETVMNAHQLDALICIPNCDKITPGMLMGALRVNVPTIFVSGGPMASGVTKKGEKISLSSVFEAVGAYEAKKISEEEFKDIECSACPSGGSCSGMFTANSMNTLCEAMGIALEGNGTILALSKEREELLRKAARRICEIALDERFKIRNIITQKAVRNAMIVDMAMGGSSNTVLHMLAISREAGVALDIKDLNFISSKVAHIAKIAPSLNSVYMDDIHKAGGVSAVMAEISSRQGHILELDALTITGESLEERLKNAKIKDENIIRKVDNAYSKVGGLAILFGNLAEQGCVIKTAGIIGERKFKGKAVCFNSQDEAIKGIIKGKVQKGNVCVIRYEGPKGGPGMQEMLSPTSLLMGMGLGADVALITDGRFSGATRGLSIGHISPEAAEGGLIGLLKDGDEIEIDVDAYTIHANLSEKEITQRKKEFVLPQKEVPSRWLRMYQKLVSNASKGAVLDME
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RL29_MYCMM
Sequence: MAVGISPGELRELTEEELTERLRESKEELFNLRFQMATGQLNNNRRLRTVRQEIARVYTVLRERELGLAAGPGEPDGKES
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: GLO22_ECOLI
Sequence: MNYRIIPVTAFSQNCSLIWCEQTRLAALVDPGGDAEKIKQEVDDSGLTLMQILLTHGHLDHVGAAAELAQHYGVPVFGPEKEDEFWLQGLPAQSRMFGLEECQPLTPDRWLNEGDTISIGNVTLQVLHCPGHTPGHVVFFDDRAKLLISGDVIFKGGVGRSDFPRGDHNQLISSIKDKLLPLGDDVIFIPGHGPLSTLGYERLHNPFLQDEMPVW
What is the function of this protein?
Type II glyoxalase, isozyme of GloB, that hydrolyzes (R)-S-lactoylglutathione to (R)-lactate and glutathione.  Plays a minor contribution to methylglyoxal (MG) detoxification in E. coli, compared to GloB.  The two isoenzymes have additive effects and ensure maximal MG degradation.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase GloC, Accessory type II glyoxalase, Glyoxalase II 2, GlxII-2.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: HPT_MUSSA
Sequence: MRALGAVVTLLLWGQLFAAELGNDAMDFEDDSCPKPPEIANGYVEHLVRYRCRQFYRLRTEGDGVYTLNDEKQWVNTAAGEKLPECEAVCGKPKHPVVQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAKNLFLNHSETASAKDIAPTLTLYVGKNQLVEIEKVVLHPNHSVVDIGLIKLKQRVLVTERVMPICLPSKDYVAPGRVGYLSGWGRNVNFRFTERFKYVMLPVADQDKCVVHYENSTVPEKKNFTSPVGVQPILNEHTFCVGLSRYQEDTCYGDAGSAFAIHDMEEDTWXAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAKK
What is the function of this protein?
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine.  Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage.  Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response.  Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
What are the official names of this protein?
Haptoglobin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DDX49_MOUSE
Sequence: MAGFAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLLEQGCTDFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEPFFWEAQATVRTVEQLDQRYLLVPEKVKDAYLVHLVQTFQDQLEDCSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQLAELVVEEAEVLQILTQVNVVRRECEIKLEASHFDEKKEINKRKQMILEGKDPDLEAKRKAELAKIKQQNRRFKEKVGQTLRRQKAGSTVRRSRPPRSRPQEPAQAEAQD
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX49, DEAD box protein 49.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
Protein: MED10_HUMAN
Sequence: MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 10, Mediator complex subunit 10, Transformation-related gene 17 protein, TRG-17, Transformation-related gene 20 protein, TRG-20.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRYS_CRIFA
Sequence: MASAERVPVSFNKPGRVPFGEVQGYAPGHIPAYSNKHDHFFSGERSIDDNVFCGFKYQCVEFARRWLLERKGLVLPDVNWACHIFKLKNVKDAATAEEVPVIAVRNGTEAKPEPDTLIIYPSSDVNTVGHVGAITEVGDDYVCIADQNYRFHKWEASYSYKLKLQHKDGVWTIIDDIDPNDVEIPLGWVTFPGYENRPEGAAPPALHPSLHFQPPEEPYLVRKTYEPTETKANWLDLNDPAEKLFVEEFGMDVSRSRLEETTVNYYECDHEFHLRCIAYGTQLHDYFMEATAQVINDDERLRIFKIPEELWPRMRHSWKYQQTYISGRFDFAYNNETHQMKCFEYNADSASTLLECGRIQQKWAESVGLDKEGTRGSGWAVERNLRTAWATCGATGRVHFLVDDEKEEQYTALYCLQAAEAVGLEGKLCVMYDEFRFNEEGYVVDSDGVRVRNIWKTWMWESAISDYFAAQAERGADWKATPADKVRLCDLMLGKDWDILYFEPMWKLIPSNKAILPIIYHNHPDHPAILRAEYELTDELRAVGYARKPIVGRVGRNVTITDGTGEVHAESGGNFGERDMIYQELFSLTKQDGYYAIIGGWMLGDAFSGTGIREDKSIITGLDSPFAAIRIKINAIPRPLTHKDLDKLAEDE
What is the function of this protein?
Conjugates glutathione (gamma-Glu-Cys-Gly) and glutathionylspermidine to form trypanothione (N(1),N(8)-bis(glutathionyl)spermidine), which is involved in maintaining intracellular thiol redox and in defense against oxidants.
What are the official names of this protein?
Trypanothione synthetase, Cf-TS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family.
Protein: RL10_PSEE4
Sequence: MAIKLEDKKAIVAEVNEAAKVALSAVVADARGVTVGAMTGLRKEAREAGVYVRVVRNTLLKRAVEGTEFSILNDAFKGPTLIAFSNEHPGAAARLFKEFAKGQDKFEIKAAAFDGKFLAANQIDVLATLPTRDEAIAQLMSVIQGATSKLARTLAALRDQKEAAAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.