PharMolix/UniProtQA huggingface dataset:
Protein: PTMAA_DANRE
Sequence: MADTKVDTSKEVSAKDLKEKKQVEEAENGKDAPANGNAENEENGDQENEVDEEDDDVAEEDEEDDGEGDDDDEDEEAEGGTGKRAAEDDDDDEDDVDPKKQKTDV
What are the official names of this protein?
Prothymosin alpha-A.
What is the protein family that this protein belongs to?
Belongs to the pro/parathymosin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y2584_MYCLE
Sequence: MDTRRRVWPVAIITPHVTDVFAQRATLTRSLQLLSEFRYEQPYPARFYRALAADTVAMVGDLWLSTHGAPPVGRILLDVGSGSGYFAAAFADAGVRYIGVEPDPREMHAAGPALVPKAGAFVRASGMALPFADDAVDICLSSNVAEHVPQPWQLGNEMLRVTKPGGLVVLSYTIWLGPFGGHEMGLTHYLGGARAATRYVRKHGHRAKNDYGSSLFPVSAADGLNWAASTGVAVAAFPRYHPRWAWWLTSVPVLREFVVSNLVLVLRPR
What are the official names of this protein?
Uncharacterized methyltransferase ML2584.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: MURC_SYNS9
Sequence: MPRLLTPQTPVHFIGVGGIGMSALAKILVDRGHPVSGSDPRDNPTVQHLESRGVTVFKEQTAECIQSVLATNQQPPVVVISTAIPDTNPELENARAHQLAIWHRSDLLAALIDQQASIAVAGSHGKTTTSTLITTLLIEAGEDPTAVIGGVVPCLGSNGHSGQGRLLVAEADESDGSLVKFRPSLGVITNLELDHTDHYDGLDDLISTLQRFGGGCERLIANYDDPILQEHFEPTAWWSNKQSENIAFAALPLQLDGDRCTARFYENGSAVGDFTLPMAGLHNLSNATAALAACRMEGIPFEALVEGLAQLQAPGRRFDLRGTWEGRHIVDDYAHHPSEVRATLTMAQLMVSSGRSPLPSPPQRLVAVFQPHRFSRTQQFFEAFAEALQNCDALLLAPVYAAGEQTIPGVCSNALAQRIRSLRPDLEIEVAENLNQLTDLVKQRSRPDDLVLAMGAGTVNSLWGRLTE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_KORCO
Sequence: MSKLLTESDSLKVIRRILEGSPKRRFNEAVDLVVVLRGIDLKRDPNAKINEVVELPHSPRNRKTKVAVIGKGEFLSKAKEAGADRVLEPEEIEAIAANKRALKKLANEYDFFIAQADVLPKIVKYIGPVLGPRNKMPINLPAMAVSQLPDLIEKLRRSVRIRTKDQPIIHTKVGSRDMKPEEIVENIRAVLSAIERKYEDPSKISRVYVKTTMGPAEELPLAAGRR
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: RS13_LEPBJ
Sequence: MARIAGIDLPREKRIVVGLTYIFGIGNSLSRVILKKAGIDESIRVKDLNESQEAAIRKALEESAKVEGDLRSEIQLNIKRLMDIGCYRGLRHRRGLPVNGQRTRTNARTRKGGKKTVANKKKVTK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MBL2_TRAOB
Sequence: MSLFPSLPLLLLSVVATSYSETVTCEDSQKICPAVIACNSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGESPDCDSSLAASERKALQTEMAHIKKWLTFSLGRQVGNKFFLTNGEMMTFDKVKALCAKFQASVATPRNAAENRAIQNLIKEEAFLGITDENTEGQFVDLIGNRLTYTNWNNGEPNNAGSDEDCVLLLKNGKWNDVPCSSSHLALCEFPI
What is the function of this protein?
Calcium-dependent lectin involved in innate immune defense.  Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.  Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
What are the official names of this protein?
Mannose-binding protein C, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin.
What are the subcellular locations of this protein?
Secreted.
Protein: LEU1_HISS2
Sequence: MQNNIIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSAGDFESVQTIARHIKNSRVCALSRAVDKDIDIAADALKVAEAFRIHTFIATSALHVEAKLRRTFDDVVEMAIQAVKRARRYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIPDTVGFCLPTEYGNIIDQVMNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTALEEVVMAIKTRQDIFKGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMVKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKSHMDAMGYQQNDYDLDKLYAAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLSLDVITSQTISNLPASAFVQVELDGKKISQVSNGGNGPVDAVYNAILAITDMDITMLHYNLTAKGEGAEALGQVDIVVEHKGRRFHGVGLATDIVESSARALIHAINAIYRANKVADLKSHKISQ
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: CAIT_ECOL5
Sequence: MKNEKRKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLIDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSVLVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD
What is the function of this protein?
Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
What are the official names of this protein?
L-carnitine/gamma-butyrobetaine antiporter.
What is the protein family that this protein belongs to?
Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPEH_PROM4
Sequence: MIGKHCILELCECNSVKLDDEAFIRTTIQMASKVAGAQLLNLITHKFVPQGVTGLALLAESHISIHTWPESGYAAVDVFTCGDQTMPDKACQLLVEELQSKRHSLKTLRRDTPVMISNALIN
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: RS16_CAMFF
Sequence: MATVVRLTRMGRNKRPFYRIVVTDSRKRRDSGWIESIGYYNPMVEPEVVKVDADRLAYWKSVGAKLSDRVARITK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RNZ_HALMA
Sequence: MTMRVTFLGTSGAVPTTQRNTSSIFVNRDGDYLLFDCGEGTQRQMMRYGTGFAIDHLFVTHLHGDHVLGIPGLLQTWDFNERERAIAIHTPAGTRGNIKQLIQANGTTPSFPVRINEVSAGDVVLDRSEYEIRAIETAHRCASVGYVLDEDDRKGKFDREKAEEEFGIPPGPKYSKLHRGEAVEHEGETIQPEAVVGPARPGRRFVYTGDTLPTESVIEASEDADLLVHDATFAEDRKERAKATAHSTAREAADVARQAGASTLALTHISTRYAASADELVDEARDAFDGEVVLAEDGMERRVEFPDADEY
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: MUTS_YERPB
Sequence: MKNNDKLDSHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYSDAKRASQLLDISLTKRGASAGEPIPMAGVPYHSIENYLAKLVQLGESAAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDAKGFGYATLDISSGRFRVAEPADLETMAAELQRTNPAELLYPENFEPMSLIEHRHGLRRRPLWEFELDTAKQQLNLQFGTRDLIGFGVEQAHLALRAAGCLLQYVKDTQRTSLPHIRGLTMERQQDGIIMDAATRRNLELTQNLSGGSENTLAAILDCSVTPMGSRMLKRWLHMPIRDIRVLTDRQQAIGGLQDIAAELQTPLRQVGDLERILARLALRTARPRDLARMRHAFQQLPEIHRLLQPIDVPHVQNLLSQVGQFDELQDLLERAIVETPPVLVRDGGVIASGYNAELDEWRALADGATDYLDRLEIREREKLGLDTLKVGFNGVHGYYIQVSRGQSHLVPIHYVRRQTLKNAERYIIPELKEYEDKVLTSKGKALAIEKGLYEEIFDLLLPHLPELQLSANALAELDVLANLAERAETLNYSCPTLSDKPGIKIMGGRHPVVEQVLKEPFISNPLTLSPQRRMLIITGPNMGGKSTYMRQTALIVLLAHLGSYVPADQATIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEQSLVLMDEIGRGTSTYDGLSLAWACAENLASRIKAMTLFATHYFELTTLPEKMEGVANVHLDALEHGETIAFMHSVQEGAASKSYGLAVAALAGVPRDVIKRARQKLKELESLSNNAAASTIDGSQMTLLNEEIPPAVEALEALDPDSLSPRQALEWIYRLKNMV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: UTP6_SCHPO
Sequence: MAEKVQYYMEQSVPELEDLLEKNIFNRDEINNIIKTRRVFEEKLARRQVKLNDFLSYIQYEINLETLRAKRHKRLNITGKITISDYAGPRKVLFLFLRATNKFFGDVTLWLDYIHYAQKIKAVNIVGKICVAALQKHPNNAELWVVACDHEFSINANVSAARALMNRALRLNQENPVIWAAYFRLELSYMTKLFARSQILTGNISSKTENITNGVSEDTIGSLSSDTIQLPMVSMEEFLGSSSSEVRKNDSDLNISDDIGNISSKEQQTQKFANVLLQIILNSRKNLSLQNYVGFFVSVLDALFECFDVPVVQYMYQENIIGICNEHFEHFKNESGEIYGVLLHRWCFLEIFIKLRGAYPSNDSGISGKGIFGLKKNDPRITSMVLTDPGFVDDLQAIVEKYQSISSDFQIPFKTKKIFYSFFVKTLHAISSSSAAESSIALALHMLVINAFQSMEKLKILTFDDSLQEIYKEAQIQSGTFMSNATLS
What is the function of this protein?
Component of the SSU processome, a pre-ribosomal particle required for the maturation of the 18S rRNA from the 35S pre-rRNA precursor.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 6, U3 snoRNA-associated protein 6.
What is the protein family that this protein belongs to?
Belongs to the UTP6 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ATPG_RHOP5
Sequence: MASLKDMRVRIASTKATQKITKAMQMVAASKLRRAQLAAEAARPYAERMDAVISNIAGAAAGSPGAPVLLAGTGKDQVHLLLVCTGERGLSGAFNSSIVRLARERAFALMNQGKEVKIFCVGRKGYEQLRRNFDRQIVENIELRSVRQLGFVNAEDIAAKVIARFDAGEFDVCTLFYSRFKSVISQIPTAQQIIPLVVEAPAAGAGPAPSYEYEPEEDEILASLLPRNLAVQIFRALLENNASFYGAQMSAMDNATRNAGDMIRKQTLIYNRTRQAMITKELIEIISGAEAI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS19_KORCO
Sequence: MSSREFRYRGYTLEQLQTMTLDELANVMPSRIRRTLKRGLSIENKKLLDKIRKYKAMGIDKVIRTHRRDMPILPEMVGSKIAVHNGKEFVEITIVPEMIGHYLGEFAMTNRIVRHGKPGKGATRSSKFVPLK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: PSMD9_RAT
Sequence: MSSEEVRHRAESSEARAAAVSDIQELMRRKEEIEAQIKANYDVLESQKGIGMNEPLVDCEGYPRADVDLYQVRTARHNIICLQNDHKALMKQVEEALHQLHARDKEKQARDMAEAREEAMNRRLASDSPALPKAFARVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLQNVGTVVQHSEGKPLNVMVIRRGEKHQLRLTPTRWAGKGLLGCNITPLQR
What is the function of this protein?
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC).  During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process (By similarity).
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 9, 26S proteasome regulatory subunit p27, Transactivating protein Bridge-1.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit p27 family.
Protein: RPOC_PARD8
Sequence: MAFRKENKIKSNFSKITIGLASPEEILENSSGEVLKPETINYRTYKPERDGLFCERIFGPIKDYECHCGKYKRIRYKGIVCDRCGVEVTEKKVRRERMGHIHLVVPVAHIWYFRSLPNKIGYLLGLPTKKLDSIIYYERYVVIQPGCVDTVGELDLLSEEEYLDILDSLPRENQLLEDTDPNKFIAKIGAEAVYDLLARLDLDSLSYELRHRANTDTSQQRKNEALKRLQVVESFRASRGRNKPEWMIMKVIPVIPPELRPLVPLDGGRFATSDLNDLYRRVIIRNNRLKRLIDIKAPEVILRNEKRMLQEAVDSLFDNSRKSSAVKTDANRPLKSLSDSLKGKQGRFRQNLLGKRVDYSARSVIVVGPELKMHECGLPKNMAAELYKPFVIRKLIECGIVKTVKSAKKIVDRKEPVVWDILEYVMKGHPVLLNRAPTLHRLGIQAFQPKLIEGKAIQLHPLACTAFNADFDGDQMAVHLPLGNEAVLEAQMLMLASHNILNPANGAPITVPSQDMVLGLYYITKLRKGTQGEGLTFYGPEEATIAYNEKKLDIHAPIHVYVEDLDENGNLVKTMVETSVGRLMVNEFVPKEIGYVNEVLGKKSLRDIIGRVIKACGVARTAQFLDDIKNLGYYMAFKGGLSFNLADVLIPPEKDELVQKGYDEVEQIMANYNMGFITNNERYNQIIDTWTHVNSNLSNILIKQLTADNDGFNSIYMMMDSGARGSKEQIRQLSGMRGLMAKPQKSGAEGGQIIENPILSNFKEGLSVLEYFISTHGARKGLADTALKTADAGYLTRRLVDVSHDVIVNEEDCGTLRGLVCTELKNNEEVIASLYERILGRVSVHDVIHPITGEVIVRSGEEIREDAAKAIQDSPIESVEIRSVLTCESKKGVCAKCYGRNLATNRMVQKGEVVGVIAAQSIGEPGTQLTLRTFHVGGIASNIATENSITSKYDGILEIDELRAVEAVDEVSGKKHLVVVSRLAEMRIVDPNTKIVLLTHNIPYGSKLFFNNGDSIKKGDVIIEWDPFNAVIVSEVSGKIEFESLVENVTYKVESDETTGLKEKIIIESKDKTKAPAAHIVDENGNYLKNYSLPLGAHVVKDNGDVVKAGEVLVKIPRAVGKAGDITGGLPRVTELFEARNPSNPAVVSEIDGEVGFGKIKRGNREITVTSKLGEVKKYMVPLSKQLLVQENDYIRAGMPLSDGATTPSDILAIKGPTAVQEYIVNEVQDVYRLQGVKINDKHFEVIVRQMMRKVEVVDPGDTRFLEQQIVDKLEVMDENDRIWGKKVVTDPGDSQTLQAGQIVTARKLRDENSMLKRRDLKLVEVRDAIPATANQILQGITRAALQTNSFMSAASFQETTKVLNEAAINGKVDRLEGLKENVICGHLIPAGTGQREFDKLIVGAKDEFDRIFANRKNVVDFNAMDKDDEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PSA_SULIY
Sequence: MAFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSGVVIASEKRKAQSLLDVDSIEKVFLIDDHVGCSFAGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVADVKQMYTQHGGVRPFGVALVIAGIDKSVPKLYMTEPSGQYMPYQAVAIGQGYYTATEFLEKNYKEDLTIEDTILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTSEDKNMYLQKL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PsmA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPAC_STRS2
Sequence: MSKFLVFGHRNPDTDAIASSYGWAHLEREVFGRDAEAVVLGTPNEETAFALDYFGVTAPRVVESAKAEGVSQVILTDHNEFQQSIADIKEVEVAAVIDHHRVANFETANPLYMRLEPVGSASSIVYRAFKENGVIPPKEVAGLLLSGLISDTLLLKSPTTHVTDPQVAAELAEIAGVNLEEYGLALLKAGTNLASKSAEELIDIDAKTFGLNGNDVRVAQVNTVDIAEVLERQAEIEAAMTAASVANGYSDFVLMITDIVNSNSEILALGSNMDKVEAAFNFKLENNHAFLAGAVSRKKQVVPQLTDAFNA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_BACTN
Sequence: MKQEFTRIAVKVGSNVLARRDGTLDVTRMSALVDQIAELNKSGVEIILISSGAVASGRSEIHPQKKLDSVDQRQLFSAVGQAKLINRYYELFREHGIAVGQVLTTKENFSTRRHYLNQKNCMTVMLENGVIPIVNENDTISVSELMFTDNDELSGLIASMMDAQALIILSNIDGIYNGSPSDPASAVIREIEHGKDLSNYIQATKSSFGRGGMLTKTNIARKVADEGITVIIANGKRDNILVDLLQQPDDTVCTRFIPSTEAVSSVKKWIAHSEGFAKGEIHINECATDILSSEKAASILPVGITHIEGEFEKDDIVRIMDFLGNQVGVGKANCDSAQAREAMGKHGKKPVVHYDYLYIE
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAGR1_HUMAN
Sequence: MSLARGHGDTAASTAAPLSEEGEVTSGLQALAVEDTGGPSASAGKAEDEGEGGREETEREGSGGEEAQGEVPSAGGEEPAEEDSEDWCVPCSDEEVELPADGQPWMPPPSEIQRLYELLAAHGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEDPSPASPPLRSSGSSLFPRQRKY
What is the function of this protein?
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation.  However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex.  Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460).  However, its function in DNA damage has been questioned (By similarity).  During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity).  Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327).  Acts as transcriptional cofactor for nuclear hormone receptors.  Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582).
What are the official names of this protein?
PAXIP1-associated glutamate-rich protein 1, Glutamate-rich coactivator interacting with SRC1, GAS, PAXIP1-associated protein 1, PTIP-associated protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: TSN9_DANRE
Sequence: MARGCLCCVKYMMFLFNLLFWLSGCGLLGVGIWLSVSQGSFATFSPSFPSLSAANLVITLGSVVMVTGFLGCLGAIKENKCLLLSFFIVLLIILLAELILLILFFVYTEKVSENAKQDLKDGLRLYNTDNNVGLRNAWNIIQAEWQCCGVTGLSDWHEALQEKSVPDRCCQEHYTECGRNTTNVFWSQGCYEKVEEWLNDNKHLLGTIAMCVLVLQLLGMAFSMTLYQQIHRAGKKYDA
What are the official names of this protein?
Tetraspanin-9, Tspan-9.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYT_RICFE
Sequence: MINISFPDGSVKQFESNITAFEVANAISMSLAKAAMVAEINGELKDLSTIIENDCKLRILTAKDSECLEIIRHDAAHIIAEAAKELFPDIQVTIGPAIENGFFYDFAKDKPFTPDDVAMIEARMHEIVKRNEQITRELWDRDKAVEFFKSIGEHYKAEIIASIPAGEPITLYRQGSFIDLCRGPHAPSTGFVKHFKLMKVAGAYWRGDSRNEMLQRIYGTAWATKEQLDNYLFMLEEAEKRDHRKLGRELDLFHFQEEAQGMVFWHDKGWSIYNTIEQYIRKKIRKNGYTEVKTPVLVDKSLWEASGHWEKFREDMFALETDDKTLALKPMNCPCHVQIFKQGIKSYRDLPLRMSEFGLCHRNEASGALHGLMRVRSLVQDDAHIFCAEEQITDETVSFCKLLTEVYKDFGFTDIKVKFSDRPEIRAGSDEVWDKAENALKEAVEKAGFTYTLNPGEGAFYGPKLEFVLTDAIGRQWQCGTLQMDFVLPERLDASYIAASGEKKRPVMLHRAILGSLERFIGILIEEYAGRFPIWLAPIQVAIATITSDLNDYALEVQKALIDNGVRTDINISPDKINYKIREFSNQKIPMIAVIGKQEKENKHVTIRRLGTTDQEVLSIEQLIALIKKENEKYL
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMBD1_ASPOR
Sequence: MALLQTSLIWAVYAIVVAILAAVASVFIYTYQTPRDRCPSVILTCIVAVTTLLATVLLVPVDVALVSSTINPALGRRQDWATQSEVDRILLCLKIVYYFLYSLDALLCLIVIPFIYFLYEEYDEVASETEQQSFGQRFWAAFKYTVSFLAIVVVLFLVGFFVPVAKDGDGGGLDYFKHLLTENRGERALTFALGLLITIGLCLYVLYTSTGLALFPITLIKEGPSVISPTLKATTAVQLCSNRERQRQLEGRCRGNPGLLSSKDRRELDTLVREERTLIRRQRLADEAHGKHQNWLMQLWLKFGAIFRPFQLLSGVIFSLLALIIWISMLLTTIDKAKNSFCKQRCGYILGHINVFNPINWVFVQSAKIFPVDYVIFTLLVLFLFSSSIVGISAVGIRFLWIRIFQIRKGHTSPQALLLATAMLMLIILALNYSTSMILAPQYATYGPQTFCDRELSFSEKQPDCSRDKHLIRPCSEVADSLAAKQVCTPSVVSTFLNRVTMNFPFFGAIFFWAQFAFLGIYLLVMVTALLHSPKLDERQLDEDAEEAEEESLLANTRGRAETTWEDITSRLRRQNEVDRAGA
What is the function of this protein?
Probable lysosomal cobalamin transporter.  Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).
What are the official names of this protein?
Probable lysosomal cobalamin transporter.
What is the protein family that this protein belongs to?
Belongs to the LIMR family. LMBRD1 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: CYB_BRANP
Sequence: MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLAACLAVQILTGLFLAMHYTSDTATAFDSVAHICRDVNYGWTLRYLHANGASMFFICLYLHVGRGLYYGSYTYSETWNVGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVSALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLIMLTALSALVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIVPMLHISKQRSMMFRPLSQCLFWLLVAVLLTLTWIGGQPVEYPYVIIGQVASVLYFLIFLVFMPLVSAMENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
Protein: SYH_MYCPN
Sequence: MSVLQKPRGVKDWYGEELIYFNWTVHQITNLAWKWGFSEVKTPLLEYAEAFKRTNANADIVKKELYEFHDKSNRLLALRPEATAGIVRLVCENKLLQPQNYPLRLFTIGTMYRYERPQSNRYREHYQFSCEVIGDTNPTVLLDTLLLGHAIIQQLGIEGVILKLNNLGNSATIQQWNQALQAYLTQFKAQLTELSQSRLSTNPLRILDDKVDGQLPFISDAPQIEQFLDAEQQALNTWLQQQLTQQQVPFEWNPTLVRGLDYYTGVVFEFVKDDTTVLAGGVYDNLVEELGGTPTKALGFACGIERSINCLSAVKKQAILANQPPRLLVIGLTEAALEKLLQLSLGWRAYHPVTIYPKVIRIINGIRAAQRLGYRFLGVIGGNNLEQQTITVKDLATEQQTTYTWDEFRQRQVL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UXUA_SALSV
Sequence: MKQTWRWYGPNDPVTLSDVRQAGATGVVTALHHIPNGEIWSVDEIQKRKAIVEEAGLEWSVVESVPIHEDIKTHTGQYDLWIKNYQQTLRNLAQCGIYTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFELHILKRPGAEADYTAEEIAQAERRFATMSEEDKARLTRNIIAGLPGAEEGYTLEQFRQHLATYKDIDKAKLREHFAYFLKAIIPVADEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVETVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTLREENPKTFHEAAHLHGDVDMYEVVKAIVEEEHRRKAEGSDDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIQRAFFSK
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: XTH15_ARATH
Sequence: MGPSSSLTTIVATVLLVTLFGSAYASNFFDEFDLTWGDHRGKIFNGGNMLSLSLDQVSGSGFKSKKEYLFGRIDMQLKLVAGNSAGTVTAYYLSSQGATHDEIDFEFLGNETGKPYVLHTNVFAQGKGDREQQFYLWFDPTKNFHTYSIVWRPQHIIFLVDNLPIRVFNNAEKLGVPFPKSQPMRIYSSLWNADDWATRGGLVKTDWSKAPFTAYYRGFNAAACTASSGCDPKFKSSFGDGKLQVATELNAYGRRRLRWVQKYFMIYNYCSDLKRFPRGFPPECKKSRV
What is the function of this protein?
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET).  Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.  Has a high XET activity, but little or no XEH activity in vitro.  Acceptor preferences are XXXGol > XLLGol = XLFGol > XXLGol > XXFGol.
What are the official names of this protein?
Xyloglucan endotransglucosylase/hydrolase protein 15, At-XTH15, XTH-15.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family. XTH group 2 subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted, extracellular space, apoplast.