PharMolix/UniProtQA huggingface dataset:
Protein: UPC2_YEAST
Sequence: MSEVGIQNHKKAVTKPRRREKVIELIEVDGKKVSTTSTGKRKFHNKSKNGCDNCKRRRVKCDEGKPACRKCTNMKLECQYTPIHLRKGRGATVVKYVTRKADGSVESDSSVDLPPTIKKEQTPFNDIQSAVKASGSSNDSFPSSASTTKSESEEKSSAPIEDKNNMTPLSMGLQGTINKKDMMNNFFSQNGTIGFGSPERLNSGIDGLLLPPLPSGNMGAFQLQQQQQVQQQSQPQTQAQQASGTPNERYGSFDLAGSPALQSTGMSLSNSLSGMLLCNRIPSGQNYTQQQLQYQLHQQLQLQQHQQVQLQQYQQLRQEQHQQVQQQQQEQLQQYQQHFLQQQQQVLLQQEQQPNDEEGGVQEENSKKVKEGPLQSQTSETTLNSDAATLQADALSQLSKMGLSLKSLSTFPTAGIGGVSYDFQELLGIKFPINNGNSRATKASNAEEALANMQEHHERAAASVKENDGQLSDTKSPAPSNNAQGGSASIMEPQAADAVSTMAPISMIERNMNRNSNISPSTPSAVLNDRQEMQDSISSLGNLTKAALENNEPTISLQTSQTENEDDASRQDMTSKINNEADRSSVSAGTSNIAKLLDLSTKGNLNLIDMKLFHHYCTKVWPTITAAKVSGPEIWRDYIPELAFDYPFLMHALLAFSATHLSRTETGLEQYVSSHRLDALRLLREAVLEISENNTDALVASALILIMDSLANASGNGTVGNQSLNSMSPSAWIFHVKGAATILTAVWPLSERSKFHNIISVDLSDLGDVINPDVGTITELVCFDESIADLYPVGLDSPYLITLAYLDKLHREKNQGDFILRVFTFPALLDKTFLALLMTGDLGAMRIMRSYYKLLRGFATEVKDKVWFLEGVTQVLPQDVDEYSGGGGMHMMLDFLGGGLPSMTTTNFSDFSL
What is the function of this protein?
Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c.  Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes.  Involved in sterol uptake and regulation of the sterol biosynthesis.  Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters.  May be involved in down-regulation of CWP2 during anaerobic adaptation.
What are the official names of this protein?
Sterol uptake control protein 2, Mannoprotein regulation by oxygen protein 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDRP_EHRRW
Sequence: MSNPVVLNLHLISDSTCETVAAVARSALEHFKSVEVNEFVWSCINSYEQIDKIMLTIEKDKYNFIMYTMFDDDIRKYLKQKAGIHEIPCIPILSHVIREISCYLNIKKDPYINTSIGLDDEYFTRIDAINYTIAHDDGQNLWDIDQADIIILGVSRTSKSPTSIYLAYRGYRVVNIPLINSIELSVDLSKMKNKLIVGLTIDIDRLIEIRRARLVSMKNQNNYGYVDYEHVLMEIRETKKICAKNGWPIIDVTQKSVEEIAATIIQYFTKMQH
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: MURC_ACAM1
Sequence: MQSAVDLGGRPIHFIGVGGIGMSALAHILLKRQLPISGSDARANHITQKLESQGAQIFSRQEATNIKQLCQGSSAPPQVICSTAIHEDNPEYQAAVQAGCPIFHRSDVLAALMQEFPQSIAIAGTHGKTTTSSLVGYLLLQASLDPTIIVGGEVAAWGGNARTGESPYLVAEADESDGSLVKFFPHIGVITNIELDHPDHYTSLDQVVSIFQEFVDHCHTLIVSVDCPTIADRFLALATDQSMITYSLSSKVSADYTVQNIDYSGQGTIVEVLERGESLGQLELPLLGEHNLSNALAAVAVGRYVGLEFPAIAKALRTFSGAKRRFEIYGEAQGICLIDDYAHHPSEIQVTLASAKLQAQAAAATYSQSRVVAVFQPHRYSRAATFFQEFSQSFQDADLVVVTDIYSAGEANPGTINGKKLADAIAANHSVVTFQPTLTNVIDFLQGHLQSGDVVLFLGAGDLNRIIPDLLTHFQVSSKPSPEVVLK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y470_STRMU
Sequence: MTTILVTGYKNFELGIFQDKDPKITIIKKAIKRDFIHFLEEGVDWFVFMGNLGFEYWALEVALSLQTEYDMQLATIFPFENHGEHWSEANQEKLFKFKQTDFVKSSYKRYQNSYQFKKYNQFLLDNTDRAYLFYDKDKETNLKYLYQMMTAKDNYPVSLLTFEDLDDIVQDFD
What are the official names of this protein?
UPF0398 protein SMU_470.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: CA1A_CONRE
Sequence: SNKRKNAAMLDMIAQHAIRGCCSDPRCRYRCR
What is the function of this protein?
This toxin target two types of receptors, the nicotinic acetylcholine receptor (nAChR) and the G-protein-coupled receptor GABA(B).  It specifically inhibits the alpha-9-alpha-10/CHRNA9-CHRNA10 nAChR, with preference for rat receptors (PubMed:16445293, PubMed:21888386, PubMed:22774872, PubMed:25740413, PubMed:28223528, PubMed:18242183, PubMed:18295795).  It interacts with the alpha-10(+)/alpha-9(-)interface of the receptor (PubMed:25740413).  It shows a two order of magnitude species difference potency for the rat versus human alpha-9-alpha-10 nAChR, due to the Thr-86 located in the alpha-9 nAChR subunit (PubMed:22774872).  This toxin also shows inhibition of high voltage-activated (HVA) calcium channels (Cav2. 2) by acting on GABA(B) receptors (GABBR1 and GABBR2) (PubMed:18945902, PubMed:21888386).  In vivo, this toxin produces an acute antinociceptive effect in peripheral nerve-injured rats, which may be related to the inhibition of immune cell buildup at the site of nerve injury (PubMed:17101979).  In addition, when intramuscularly injected into rats following chronic constriction injury of the sciatic nerve, this toxin protects peripheral nervous tissues as well as prevents central maladaptive plasticity by inhibiting glial cell activation (PubMed:25008370).
What are the official names of this protein?
Alpha-conotoxin RgIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SMG_ECOK1
Sequence: MFDVLMYLFETYIHTEAELRVDQDKLEQDLTDAGFDREDIYNALLWLEKLADYQEGLAEPMQLASDPLSMRIYTPEECERLDASCRGFLLFLEQIQVLNLETREMVIERVLALDTAEFDLEDLKWVILMVLFNIPGCENAYQQMEELLFEVNEGMLH
What are the official names of this protein?
Protein Smg.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: HRTA_STAA8
Sequence: MALVVEDIVKNFGEGLSETKVLKGINFEVEQGEFVILNGASGSGKTTLLTILGGLLSQTSGTVLYNDAPLFDKQHRPSDLRLEDIGFIFQSSHLVPYLKVIEQLTLVGQEAGMTKQQSSTRAIQLLKNIGLEDRLNVYPHQLSGGEKQRVAIMRAFMNNPKIILADEPTASLDADRATKVVEMIRQQIKEQQMIGIMITHDRRLFEYADRVIELEDGKITD
What is the function of this protein?
Part of the ABC transporter complex hrt involved in hemin import.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative hemin import ATP-binding protein HrtA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. HrtA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RADA_STRPQ
Sequence: MAKKKATFICQECGYQSPKYLGRCPNCSAWSSFVEEVEVKEVKNARVSLAGEKSRPVKLKDVDNISYHRTQTDMSEFNRVLGGGVVPGSLILIGGDPGIGKSTLLLQVSTQLANKGTVLYASGEESAEQIKLRSERLGDIDNEFYLYAETNMQAIRTEIENIKPDFLIIDSIQTIMSPDITGVQGSVSQVREVTAELMQLAKTNNIATFIVGHVTKEGTLAGPRMLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEIGIFEMQSGGLVEVLNPSQVFLEERLDGATGSAVVVTMEGSRPILAEVQSLVTPTVFGNARRTTTGLDFNRVSLIMAVLEKRCGLLLQNQDAYLKSAGGVKLDEPAIDLAVAVAIASSYKEKPTSPQEAFLGEIGLTGEIRRVTRIEQRINEAAKLGFTKVYAPKNALQGIDISQGIEVVGVTTVGQVLKAVFS
What is the function of this protein?
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks.  Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster.  Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB.  Does not have RecA's homology-searching function.
What are the official names of this protein?
DNA repair protein RadA, Branch migration protein RadA.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RadA subfamily.
Protein: CSPL7_ORYSI
Sequence: MFSAKARWIVAVVLRVAAAGAAAVAAVLMAMSHDEVIVYGMEVQAKFRYTPSLVFFVAANAAVSACSLVVLLVPSSTSKLAARLLLMADVVLGMVLAGAFAAAGAMAELGKNGNSHAGWIAICVQVPLFCDRVRSALVAGSATIVLYYLMLMYSIYTLPMFP
What are the official names of this protein?
CASP-like protein 1C1-2, OsCASPL1C1-2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SURE_XANOP
Sequence: MRVLVSNDDGVDAPGIQILAEALRHGGHEVMVVAPDRDRSGASNSLTLDVPIRTRRIDAQTCAVAGTPTDCVHLALTGMLDCDPDIVVSGINNSANLGDDVIYSGTVSAAMEGRFLGLPAVAVSLVTHNHQAHHYDTAARAAVEIVARLKADPLPADTILNVNVPDLAWSDVLGFEVTRLGNRHRSEPCVPQRDPRGRTVYWIGPAGPEQDAGAGTDFHAVRTGHISITPIHVDLTRYQALETVAGWVGGLTAALDGPA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHEB_YERPN
Sequence: MSKIRVLCVDDSALMRQLMTEIINSHPDMEMVAAAQDPLVARDLIKKFNPQVLTLDVEMPRMDGLDFLEKLMRLRPMPVVMVSSLTGKNSEITMRALELGAIDFVTKPQLGIREGMLAYSELIADKIRTAAKARLPQRVLENKPAMLSHTPLLSSEKLIAIGASTGGTEAIRAVLQPLPPTSPALLITQHMPPGFTRSFAERLNKLCQITVKEAEDGERVLPGHAYIAPGDRHLELARSGANYQVRIHDGPAVNRHRPSVDVLFRSVAQYAGRNAVGVILTGMGNDGAAGLLEMHRAGAYTLAQNEASCVVFGMPREAIAMGGVNDVVELNQISQRMLAQISSGQALRI
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METAA_METII
Sequence: MPINIPDDLPAASILESEKIFVMNENRARHQDIRPLEILIFNLMPSKVETETQILRLLSNSPIQIDIDLLRTETYISKHTSQDYLQHFYKTFNEIKNKKYDGMIITGAPVENMPYESVKYWKEFCEILDWSLTNSFSTMHICWGALAALYYHYGIPKHPLDEKISGIYAHVPLEYYHPLLRGFDDVFYMPHSRYMTVKESDLKGDLKVLARSEETGPAIIMSDKLRQVFVTGHLEYDTMTLANEYKRDLEKGLHPVIPENYFPDNDPNAAPKKLWRSHASLLFSNWLNYYVYQQTPYDLLKIGRS
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IKZF_MYXGL
Sequence: MIQGSAPGGLSRLPSNKLTCEICGMVCIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHVKLHTDEKPFKCSLCSYACRRRDALMGHIRTHSVGKPYKCNFCSRSYKQRSSLEEHQERCPGFHQGLPSSHLAENAFSKYGTTTERADWEHVIRPGQEPPLLDDSALLPTDVRLGLDPAIETQLEPGFDKLSNQDRFSNNFQAKRKSSTPQKVFGQKRMQLELSDIHYDQATSSLSERLHEVPGPVCAQTLEPSASVFLNTPSPVTRSAGQALEATRRLESESPGLPSDIGSIVRPVYSQSVDNRFQHDSPLSTSRSGLSQQPGRHHPSPGILGGSLGGICGRPAEAVGDSRPVNMPPGRGATSSPSNSCPDSTDTESSHEERSHHRTGSGSSTSRPNGSTGRPHRPEMHQDNGRLNRVSGASDSSSLPTYNVSGSDGEALRTYPCHHCGLLFLDHVMYTLHMGCHGFRDPFECNVCGYRSRDRYEFSSHIIRGEHLPTAE
What are the official names of this protein?
Ikaros family zinc finger protein, Ikaros-like transcription factor, HIL.
What is the protein family that this protein belongs to?
Belongs to the Ikaros C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KDSA_NEIM0
Sequence: MDIKINDFTLGNNSPFVLFGGINVLESLDSTLQTCAHYVEVTRKLGIPYIFKASFDKANRSSIHSYRGVGLEEGLKIFEKVKAEFGIPVITDVHEPHQCQPVAEVCDVIQLPAFLARQTDLVVAMAKTGNVVNIKKPQFLSPSQMKNIVEKFHEAGNGKLILCERGSSFGYDNLVVDMLGFGVMKQTCGNLPVIFDVTHSLQTRDAGSAASGGRRAQALDLALAGMATRLAGLFLESHPDPKLAKCDGPSALPLHLLEDFLIRIKALDDLIKSQPILTIE
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT25_LODEL
Sequence: MRIQTDAVNVVSRASSYLLSGLLKRKPLWFDVVAKYPPKQNLIKVPYIQSKENKDPRNDQFELKKRDRKRPLSALYQTRASKMENGNLNRKIHRIPKLKFLEDEIRDYFHLRHPWENARPKTLVENSGDEVLRKCDWSRMLQLYKPLDGESVVQRTMYILQNDPEVKDVFEAYDIARFEYYKLRMAEEMESHVAKEESVMHGAVFESTHLDWNLTTEQKYIDDWVKIASEKTQVLEANRSKSNAPAGSMGGEEVEAAQVSIFEVFCKLVHQRELKVSKERRSRVQQKTHEETSRALYIIEMKMKRILEK
What are the official names of this protein?
37S ribosomal protein S25, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS23 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TMCAL_BACAN
Sequence: MQQTKKLTHSDITIAVMSGPFLQRGEPALVSKWYRTKMALACGVDLVVELPYAFSTQKAETFANGAISILNALHVSEICFGSEDGQIENFYNTISVQKNEEETFNRLVKQFMNAGNSYAKATSEAFLHILSSEKNIDMSQPNNILGFQYIKAILMQNSSMQAQTIKRFASHYHDETFNDQHIASATSIRKQLFSENSSFTEIESFIPKATASLLASYKQNYGTLHNWEQYFSFFKYKLMTMSPENLRHIYEIEEGLEHRILSKIQTSSSFHSFMESLKTKRYTWTRLQRACTHILTNTTKEEIYCANIEQHAPYIRLLGMSQKGQTYLSKNKKKIELPILTHTKTFDHPTLHIERKANSVYFSIMKEPLRTQLLKRDATHHPIRYDETTAKFL
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABC3G_PAPAN
Sequence: MKPQFRNTVERMYRDTFFYNFNNRPILSRRNTVWLCYEVKTRGPSMPTWDAKIFRGQVYSKAKYHPEMRFLHWFRKWRQLHRDQEYEVTWYVSWSPCTGCANSVATFLAEDPKVTLTIFVARLYYFWKPDYQEALRVLCQKRGSPHATMKIMNYNEFQHCWNKFVRGRREPFEPWENLPKHYTLLHATLGELLRHLMDPGTFTSNFYNKPWVSGQHETYLCYKVERLHNGTWVPLNQHRGFLRNQAPDIHGFPKGRHAELCFLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLCIFAARIYDDQGRCQEGLRTLHRDGAKIAMMNYSEFEYCWDTFVDRQGRPFQPWDGLDEHSQDLSGRLRAILQNQGN
What is the function of this protein?
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility.  After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA.  The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.  Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA (By similarity).
What are the official names of this protein?
DNA dC->dU-editing enzyme APOBEC-3G, Deoxycytidine deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic, small amount are found in the nucleus.
Protein: Y023_SYNS9
Sequence: MAGFGLPNFGQLTEAFRKAQQIQQDAQALQEELDGMEIEGKNSDGRASVWLSGNQQPLRVRLDPALVQDGAEACETATLEALQAAYEQSTATMKGRMEELTGGLNLNLPGMGG
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Syncc9902_0023.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MRAY_STRPC
Sequence: MFLTLIAAIISFMVSAFTMPYFIKFYQLKKIGGQQMHEDVKQHLAKAGTPTMGGTVFLLVATAVSLLVSLFSIKNTQSLALISGILSIVVIYGIIGFLDDFLKIFKQINEGLTAKQKLALQLVGGLMFYFLHVSPSGISSINVFGYQLPLGIFYLFFVLFWVVGFSNAVNLTDGIDGLASISVVISLVTYGVIAYVQSQFDVLLLIGAMIGALLGFFCFNHKPAKVFMGDVGSLALGAMLAAISIALRQEWTLLIIGIVYVLETSSVMLQVSYFKYTKKKYGEGRRIFRMTPFHHHLELGGLSGKGKKWSEWQVDAFLWGVGSLASLLVLAILYVF
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLMM_FRATO
Sequence: MAKYFGTDGIRGEVANSTITVEFTQKLGNAVGSLINQKNYPKFVIVGQDTRSSGGFLKFALVSGLNAAGIDVLDLGVVPTPVVAFMTVKHRAAAGFVITASHNKFTDNGIKLFSSNGFKLDDALEEEVEDMIDGDFIYQPQFKFGSYKILANAIDEYIESIHSRFAKFVNYKGKVVVDCAHGAASHNFEALLDKFGINYVSIASNPDGLNINVGCGATCVSNIKKAVKEQKADLGISLDGDADRIIIVDENGQEIDGDGILNILAQYSDICGGTNGIVGTQMTNMSYENHYRANKIPFIRSKVGDRYVLEDLVKYGYKIGGESSGHVINLNFGTTGDGLFTAIQLLAIFSQAYKPVSEFKLQGELMQQTLINVPLTKKVAREDLQKVASDVNDVEKRLGNRGRVLLRPSGTEPVLRVMVEADDKSLATNEAEYLVEKVKQKLV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MRAY_SODGM
Sequence: MLVWLAEHLVQFYSGFNVFSYLTFRAIVSLLTALFLSLWMGPRLIAWLQKLQIAQVVRNDGPESHFSKRGTPTMGGLMILTSITISVLMWAYPSNPYVWCVLFVLVGYGIVGFIDDYRKVVRKDTKGLIVRWKYFWQSVIALAVAFTMFAVGKDTPATQLAVPFFKDIMPQLGLWYVLLAYFVIVGTSNAVNLTDGLDGLAIMPTVFVAAGLALVAWATGNMNFAGYLHIPYVRFAGELVVVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGTIAVLLRQEFLLLIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: S22A6_PSEAM
Sequence: MPFSELLEQVGSTGRFQVLHVTLLCIPVLMMASHNLLQNFVATVPSHYCNAHANLSQARLSLEESLLITVPLDGAGKPQRCQRYAAPQWHLLGKNGTSGSGDLADATESMDAALQECSDGWSYNSTVRSSTIISEWHLVCDMHSFKQMGQTIYMGGVLVGALLFGGLSDRYGRRILLLISNLLMAVSGTCAAFSSSFSLFCVFRFGCGLALSGLGLNTFSLIVEWIPTRIRTAVGTTTGYCYTLGQLILVLLAYFIRDWRWLTLAVSLPFYVFFLIAWWFHESSRWLALSNRTEHALKNLKSVARFNGRHEEAEKLDIKMLHESMKKEMSCTQGSYSILDLFNTPAMRKRTLCLSAVWLSTSFAYYGLAMDLDKFGVDIYLIQVIFGAVDIPAKVVVVVSMSLIGRRRSQCAVLVVAGITILLNLLVPYDKQTIRTCLAVLGKGCLAASFNCCYLYSGELFPTIIRQNGMGWVSMMARIGAMVAPMVLLTRDYIPWLPGLIYGGAPILSGLAAIFLPETLGYPLPDTIQDVEESGSGRKSKMSTKETITLQDKQANLLKQSA
What is the function of this protein?
Involved in the renal elimination of endogenous and exogenous organic anions.  Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc).  Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS), 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate (By similarity).  Mediates the sodium-independent uptake of p-aminohippurate (PAH).  PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity).  PAH uptake is inhibited by glutarate.
What are the official names of this protein?
Solute carrier family 22 member 6, Organic anion transporter 1, Renal organic anion transporter 1, ROAT1, fROAT1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM2_PHYPA
Sequence: MVGVMMAAAATPGCGVSQALTACGSHEGLRRVAPVFGPGVVSVSAPCKLPRKLNVQAVAEPIAKSSPRTIEECEANVVAGNAPAAPPVPAKPSAPEGTPAISPLVMPARPRRNRRSPALRAAFQETTISPANFILPLFVHEGEQNAPIGAMPGCQRLGWRHGLIDEVYKARDVGVNSVVLFPKVPDALKSSTGDEAYNPDGLVPRCIRLLKDKFPDLVIYTDVALDPYSSDGHDGIVREDGLIMNDETVHQLCKQAVAQAQAGADVVSPSDMMDGRVGAIRKALDLAGHQDVSIMAYTAKYASAFYGPFREALDSNPRFGDKKTYQMNPANYREALIETRMDEAEGADILMVKPAMPYLDVIRLLRDNTALPISAYQVSGEYSMIRAAAAAGMLDEKKAVLESLLSIRRAGADVILTYFAIQAAQWLCAERV
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, chloroplastic, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LPXA_BURM9
Sequence: MSRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYKDEPTRLVIGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIGHDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVRIGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGGDGDAAVKSLVDFVESSQRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POP7_HUMAN
Sequence: MAENREPRGAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTDFKAQLARCQKLLDGGARGQNACSEIYIHGLGLAINRAINIALQLQAGSFGSLQVAANTSTVELVDELEPETDTREPLTRIRNNSAIHIRVFRVTPK
What is the function of this protein?
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9630247, PubMed:30454648).  Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).
What are the official names of this protein?
Ribonuclease P protein subunit p20, RNaseP protein p20, Ribonucleases P/MRP protein subunit POP7 homolog, hPOP7.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Cytoplasmic granule. Note=Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules.