PharMolix/UniProtQA huggingface dataset:
Protein: HTYD_ASPRU
Sequence: MSEGSISLCFLGSLPNDVVNFVRAVVRILADIRGIVVEERSAEELSLSNPPTLTLAALDNTEPGSPAICSLYAFLTHLCTALETIGRHAEVSSLQHVLDLCRTTTDRGGLAIIRDESSGWTSGPTQLQSVQSLIEAWLEALNAAESATQLPAPLPAKTPNTWPMTLAEKILVQHAFSLPSPQGVSVGELMRVSVDWVIASELSWVGMKHSMISIGEQPTVWRNDRFWLAGDHTVDPRTYHQPRVQELIGGMEDAKKTFKMTENQGSNYTILHTEFVRERAEPGMLVIGSDSHTCSAGAVSSLAIGLGAADVMAALATGETWFKSPESIRVEFSGEPAWYIRGKDIILYILKKLKRNTHAADRIVEFGGPGAKHLSCDARFAICNMCTELGAITGIFVPDEVTHQFISNRRHSRYRSNSVYFQPDSDASYAATFQIDLSEVESFIALYPSPDNVVPVTETLDMPLDGCFIGACTTTEEDLVLAALVLEVGLQQGLELAIGKRMVVPGSLPIVSNLRVLGLLDVFEQAGFEQPAVSCSLCLGMGADRAGHGENWLSSQNRNFKNRMGHGSIGHICSAAVVAASSFSMRVTDPRPLLSQIPPERYQTLLDKCRDWRSAEPAARRHPGKIAIANQRTKPAPTMPAYVEPYRSFQPPVPPSSDQPQSMKDHGKTSNGENGILISKVYALGDFVDTDAIIPAAFILESPTDVLLGSHCLEFTNPDFRSQVRAGLEVVVAGKAFGCGSSREEAPRALKGLGVKCVIAKSFSFIYGRNQPTIGLLGIVITDERFYDAARTGVAIEINPSARTVTVAGQSFPFVMDDMELALIRRDGLATAYKALGKGVFRSLCADVPGKGGCGQTQGTIYMQVSMSLRVTPAVSRD
What is the function of this protein?
Aconitase; part of the gene cluster that mediates the de novo generation of L-homotyrosine from acetyl-CoA and 4-hydroxyphenyl-pyruvate (PubMed:22998630).  L-homotyrosine is a building block of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent (PubMed:22998630).  L-homotyrosine 4-hydroxyphenyl-pyruvate first undergoes an aldol-type condensation by htyA with the C-2 of acetyl-CoA followed by the release of CoA to form 2-(4-hydroxybenzyl)-malate (PubMed:22998630).  This is followed by isomerization of 2-(4-hydroxy-benzyl)-malate to 3-(4-hydroxybenzyl)-malate by htyD (PubMed:22998630).  Thereafter, 3-(4-hydroxybenzyl)-malate undergoes decarboxylation and oxidation to form 2-oxo-4-(4-hydroxybenzyl)butanoic acid, coupled to reduction of NAD(+) to NADH by htyC (PubMed:22998630).  The product then undergoes transamination catalyzed by htyB to form L-homotyrosine (PubMed:22998630).
What are the official names of this protein?
Aconitase htyD, L-homotyrosine biosynthetic cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: DHSD_HALSA
Sequence: MSESYDRGLVADFGRWTEFSAGMWAWVFHKFTGWVLVGYLFTHISVLSTSLQGAQVYNSTLSGLESLAIVRLLEVGLLAVAVFHILNGIRLLFVDLGVGLEAQDKSFYASLVLTGVIVVASVPTFLTGAF
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase hydrophobic membrane anchor subunit.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PANE_MYCTO
Sequence: MATGIALVGPGAVGTTVAALLHKAGYSPLLCGHTPRAGIELRRDGADPIVVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRRDDVAALSRRYVAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
What are the official names of this protein?
2-dehydropantoate 2-reductase, Ketopantoate reductase, KPR.
What is the protein family that this protein belongs to?
Belongs to the ketopantoate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA_THET8
Sequence: MKVDLNADAGESYGAFAYGHDREIFPLVSSANLACGFHGGSPGRILEAVRLAKAHGVAVGAHPGFPDLVGFGRREMALSPEEVYADVLYQIGALSAFLKAEGLPLHHVKPHGALYLKACRDRETARAIALAVKAFDPGLPLVVLPGTVYEEEARKAGLRVVLEAFPERAYLRSGQLAPRSMPGSWITDPEEAARRALRMVLEGKVEALDGGEVAVRADTLCIHGDNPNAPEVARAVREALEQAGVEVRAF
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: HBB1_TORMA
Sequence: VSLTDEEIRLIQHIWSNVNVVEITAKALERVFYVYPWTTRLFTSFNHNFKASDKQVHDHAVNVSNAISAAIGDLHDINKNFSALSTKHQKKLGVDTSNFMLLGQAFLVELAALEKDKFTPQYHKAALKLFEVVTEALSCQYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PSBL_ATRBE
Sequence: MTQSNPNEQSVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RS13_RHOOB
Sequence: MARLAGVDLPREKRMEIALTYIYGIGRTRSKEILDATGVSPDLRSKDLSDEDLAKLREYIEESLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGLPVRGQRTKTNARTRKGPKRTIAGKKKAK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: CSLA3_ORYSJ
Sequence: MAMAGADGPTAGAAAAVRWRGGESLLLLLLRWPSSAELVAAWGAARASAVAPALAAASAACLALSAMLLADAVLMAAACFARRRPDRRYRATPLGAGAGADDDDDDEEAGRVAYPMVLVQIPMYNEREVYKLSIGAACGLSWPSDRLIVQVLDDSTDPTVKGLVELECKSWGNKGKNVKYEVRNTRKGYKAGALKEGLLRDYVQQCNYVAIFDADFQPEPDFLLRTIPYLVRNPQIGLVQAHWEFVNTSECLMTRIQKMTLHYHFKVEQEGGSSTFAFFGFNGTAGVWRISALEEAGGWKDRTTVEDMDLAVRAGLKGWKFVYLADVKVKSELPSNLKTYRHQQHRWTCGAANLFRKVGAEILFTKEVPFWWKFYLLYSFFFVRKVVAHVVPFMLYCVVIPFSVLIPEVTVPVWGVVYVPTTITLLHAIRNTSSIHFIPFWILFENVMSFHRTKAMFIGLLELGGVNEWVVTEKLGNGSNTKPASQILERPPCRFWDRWTMSEILFSIFLFFCATYNLAYGGDYYFVYIYLQAIAFLVVGIGFCGTISSNS
What is the function of this protein?
Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose.  The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase.  Galactomannan is a noncellulosic polysaccharides of plant cell wall.
What are the official names of this protein?
Probable glucomannan 4-beta-mannosyltransferase 3, Cellulose synthase-like protein A3, OsCslA3, Glucomannan synthase, Mannan synthase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: DAPB_BARHE
Sequence: MRLTVVGANGRMGRELITAIQRRKDVELCAVLVRKGSSFVDKDASILIGSDFLGVRITDDPESAFSNTEGILDFSQPQASVLYANYAAQKSLIHIIGTTGFSKTEEAQIADFAKYTTIVKSGNMSLGVNLLANLVKRAAKALDDDFDIEIYEMHHANKVDSPSGTALLLGQAAAEGRNIMLKNVSVNGRSGHTGKREKGTIGFACSRGGTVIGDHSITFAGENERIVLSHIAQERSIFANGALKAALWAKNHENGLYSMLDVLGLNE
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IGW3_HETFR
Sequence: NIVLTQPESAVKKPGESHKLSCTVSGFDVNGHHMNWVKQVPGEGLEWLLSYRKTYNTYYASGIQGRITFSTESSTTFIEIPNLRVEDTAMYYCARGTGFPQWGYWGSGTFLTVTSVTQ
What are the official names of this protein?
IgW heavy chain V region W26.
Protein: GA2L1_HUMAN
Sequence: MADPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAAARPARGVAFQAHSVVPGSFMARDNVATFIGWCRVELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQFEQEIERELRAAPPAPNAPAAGEDTTETAPAPGTPARGPRMTPSDLRNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPALRSQSRDRLDRGRPRGAPGGRGAQLSVPSPARRARSQSREEQAVLLVRRDRDGQHSWVPRGRGSGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASIFRTPLQLDPQQEQQLFRRLEEEFLANARALEAVASVTPTGPVPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGDSGRTANGLPGPRSQALSSSSDEGSPCPGMGGPLDAPGSPLACTEPSRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTWHALHSVTPRAEPDSWM
What is the function of this protein?
Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950).  Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950).
What are the official names of this protein?
GAS2-like protein 1, GAS2-related protein on chromosome 22, Growth arrest-specific protein 2-like 1.
What is the protein family that this protein belongs to?
Belongs to the GAS2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Note=Colocalizes with the tips of microtubule plus ends.
Protein: CAP12_ARATH
Sequence: MKLWKRAAAAIKDRKSLLAVGFSRRNSSYRNADLEAAIIKATSHDDSSVDYSNAHRVYKWIRSSPLNLKTLVYAISSRVNHTRSWIVALKSLMLLHGVLCCKVPSVVGEFRRLPFDLSDFSDGHSCLSKTWGFNVFVRTYFAFLHHYSSFLSDQIHRLRGNNRRSLEKTSDSVIQELERIQKLQSLLDMILQIRPVADNMKKTLILEAMDCLVIESINIYGRICGAVMKVLPLAGKSEAATVLKIVNKTTSQGEDLIVYFEFCKGFGVSNAREIPQFVRIPEEEVEAIEKMIDTVQEKPKLEKDEEKEDEKAMVVLEQPKKLQTIITDKWEIFEDDYRCFDRKDKWEIFEDEYHQNHLPLITMNQPVYITYTMPDLITF
What are the official names of this protein?
Putative clathrin assembly protein At1g68110.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalized with clathrin in the Golgi area.
Protein: MBCD_SOLTU
Sequence: MHKLFAVRSLSSAIVKSFKSLQNQQAAFSTSLLLDDTQKQFKESVAKFAQENIAPYAEKIDRTNSFPKEINLWKLMGDFNLHGITAPEEYGGLNLGYLYHCIALEEISRASGAVAVSYGVQSNVCINQLVRNGTPDQKQKYLPKLISGDHIGALAMSEPNAGSDVVSMKCRADRVDGGYVLNGNKMWCTNGPVANTLIVYAKTDTTAGSKGITAFIIEKEMPGFSTAQKLDKLGMRGSDTCELVFENCFVPNENVLGQEGKGVYVLMSGLDLERLVLAAGPVGIMQACMDIVIPYVRQREQFGRPIGEFQLIQGKLADMYTALQSSRSYVYAVAKDCDNGKIDPKDCSGTILLAAERATQVALQAIQCLGGNGYINEYPTGRLLRDAKMYEIAAGTSEIRRLVIGRELFKHQ
What is the function of this protein?
Short/branched-chain acyl-CoA dehydrogenase (SBCAD).  Uses 2-methylbutanoyl-CoA as substrate.  Minor activity with the straight-chain substrates, butanoyl-CoA, valeryl-CoA, hexanoyl-CoA, and octanoyl-CoA but no activity with isovaleryl-CoA.
What are the official names of this protein?
2-methylacyl-CoA dehydrogenase, mitochondrial, 2-methylbutanoyl-CoA dehydrogenase, 2-methylbutyryl-CoA dehydrogenase, 2MBCD, Isovaleryl-CoA dehydrogenase 1, St-IVD1.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL15_DESAH
Sequence: MKLHELSPSEGSRKKRKRVGRGPGSGMGGTSTRGNKGHNQRSGGGTRPGFEGGQMPLHRRLPKRGFKNILAKSILIVNLSDLDRFEDKAVIDVAALKQTGLIKGMFDKVKILGDGEVSKAFTFKQCLVSKTARQKIEAAGGSIEL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: CHX18_ARATH
Sequence: MATNSTKACPAPMKATSNGVFQGDNPIDFALPLAILQIVIVIVLTRVLAYLLRPLRQPRVIAEVIGGIMLGPSLLGRSKAFLDAVFPKKSLTVLETLANLGLLFFLFLAGLEIDTKALRRTGKKALGIALAGITLPFALGIGSSFVLKATISKGVNSTAFLVFMGVALSITAFPVLARILAELKLLTTEIGRLAMSAAAVNDVAAWILLALAIALSGSNTSPLVSLWVFLSGCAFVIGASFIIPPIFRWISRRCHEGEPIEETYICATLAVVLVCGFITDAIGIHSMFGAFVVGVLIPKEGPFAGALVEKVEDLVSGLFLPLYFVASGLKTNVATIQGAQSWGLLVLVTATACFGKILGTLGVSLAFKIPMREAITLGFLMNTKGLVELIVLNIGKDRKVLNDQTFAIMVLMALFTTFITTPVVMAVYKPARRAKKEGEYKHRAVERENTNTQLRILTCFHGAGSIPSMINLLEASRGIEKGEGLCVYALHLRELSERSSAILMVHKVRKNGMPFWNRRGVNADADQVVVAFQAFQQLSRVNVRPMTAISSMSDIHEDICTTAVRKKAAIVILPFHKHQQLDGSLETTRGDYRWVNRRVLLQAPCSVGIFVDRGLGGSSQVSAQDVSYSVVVLFFGGPDDREALAYGLRMAEHPGIVLTVFRFVVSPERVGEIVNVEVSNNNNENQSVKNLKSDEEIMSEIRKISSVDESVKFVEKQIENAAVDVRSAIEEVRRSNLFLVGRMPGGEIALAIRENSECPELGPVGSLLISPESSTKASVLVIQQYNGTGIAPDLGAAETEVLTSTDKDSD
What is the function of this protein?
May operate as a cation/H(+) antiporter.
What are the official names of this protein?
Cation/H(+) antiporter 18, Protein CATION/H+ EXCHANGER 18, AtCHX18.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NTPPB_ALIF1
Sequence: MQSKLILASTSPFRKEILSKIQLDFDAISPVCDETPLKNESPINLVTRLAETKANSCGIEDPNYLIIGSDQVCVINEKIVGKPLTREKAVQQLEEASGHKITFYTGLSVFNTTTKQADTICEEFNVYFRQLTRKQIENYVDKEEPFYCAGSFKCEGLGIALFEKLEGKDPNTLIGLPLISLIDMLEKQGLNVL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK2_OENBI
Sequence: MAIHLYKTSTPSTRNGAVDSQVKSNTRKNLIYGQPRCSKGRNARGIITAGHRGGGHKRLYRKIDFRRNERDIYGRIVSIEYDPNRNASICLIHYGDGEKRYILHPRGAIIGDTIVSGTEVPIKMGNALPLKMPLGTALHNIEITLGKGGQLARAAGAVAKLIAKEGKSATLKLPSGEVRLISNNCSATVGQVGNVGVNQKSLGRAGSKRWLGKRPVVRGVVMNPVDHPHGGGEGRAPIGRKKPATPWGYPALGRRSRKRNKYSENLILRRRSK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLD2_MOUSE
Sequence: MASLGVQLVGYILGLLGLLGTSIAMLLPNWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAMSSLACIISVVGMRCTVFCQDSRAKDRVAVVGGVFFILGGILGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISALFSLVAGVILCFSCSPQGNRTNYYDGYQAQPLATRSSPRSAQQPKAKSEFNSYSLTGYV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
What are the official names of this protein?
Claudin-2.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: Y2696_CROS8
Sequence: MKTKLNELLEFPTPFTYKVMGLAKPELVDLVVEVVQRHAPGDYTPQVKPSSKGNYHSVSITINATHIEQVETLYEELGDIDIVRMVL
What are the official names of this protein?
UPF0250 protein ESA_02696.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: SYH_PROMH
Sequence: MAQKIQAIRGMNDYLPADTRVWQKIENTLKQILAGYGFSEIRTPIVEHTPLFQRAIGEVTDVVEKEMYTFTDRGEDAQSLTLRPENTAGCVRAGIEHGLLYNQEQRLWYLGPMFRYERPQKGRYRQFHQLGAEVFGLQGPDIDAELIMLTARWWKALGIAEHVTLELNSIGSLEARAKYREALVAFLEQHVDQLDEDCKRRMYSNPLRVLDSKNPEIQTLLNDAPELFDYLDDESREHFDGLCALLDAVGITYRVNQRLVRGLDYYNRTVFEWVTSALGSQGTVCAGGRYDGLVKQLGGHPTPAVGFAMGMERMILLVQAVNPEFVADTHVADVYLASFGDNSQSAALMLAEEIRDQLPTLRLMTNHGKGNFKKQLGRADKHGAKIALILGEDEINAGTVAVKDLRSGEQTIVSRSELAQQLTLLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGO4_MOUSE
Sequence: MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRIDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKHPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPSQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKMNAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEITQELLYSQEVVQDLTSMARELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKMERVGKSGNVPAGTTVDSTVTHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA
What is the function of this protein?
Required for RNA-mediated gene silencing (RNAi).  Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them.  Lacks endonuclease activity and does not appear to cleave target mRNAs.
What are the official names of this protein?
Protein argonaute-4, Argonaute4, mAgo4, Argonaute RISC catalytic component 4, Eukaryotic translation initiation factor 2C 4, eIF-2C 4, eIF2C 4, Piwi/argonaute family protein meIF2C4.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body.
Protein: TIG_NOCSJ
Sequence: MKSAVETLSPTRAKLTVEVPFEELKPSLDAAYKQIAKQINVPGFRRGKVPPAIIDRQVGRGAVLDQAINDVVPQKYVEALQANSLQPLAQPEIEVTKFEDNQALEFTAEVDIRPEIALPDYDGVEAQVDDIELSDADVEEQVEALRERFATLIDVERPAAEGDFVVMDLVATRDGEPIEGAEVSGMSYRVGRGGMLDGLDEALVGMSAGDEKTFQSELVGGDMVGEAVDVAVTVSQVQEQELPELDDEFAQMASEFDTVEELTADVRERLGRGRRLEQAAAARDAVLEQLLDRVEVPLPEVVVTDELNARRQNVEQQLAYAGITMEKYLEDEGQTMEEFEADLERRVRDAVAAQFLLDEVAKKEEFGIDQAELSEHLVRRAQQSGQDPQEFANHMFEHNHIPELVQEILRGKALARIVEAAVVKDGSGNVVELKNLRPDGTIGEPEDEIEAETEIEIEPAAETDTEADTEQ
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RNF8_DANRE
Sequence: MEKTEEPPSSNNEEDSPAKEKIWCLQRVGRDSDWLRLFEDSEVSVGRGLNVTHQILSSSCPLMISRIHCVFKLNEGRQWTVTDNKSLNGVWVNGKRIPPSTPCILHQSDSVRLGVPLDGNPVEFDYILVQKNFDDVKSFLSGNLGKDSGAASLSQKLKNSKRKFDGGDESEPCPTQHSKSKLYRSSAPDKSRAQPCPSGERRETLKLSSRPLEEDRDKAGSSSSTCSDSSQHLATLHRYNRSLMVLKGRVGDTQKRAAELEQQQTQTPEREKEMQDLQTQLEALRGQLRSQQEQALRRMETLEKSFCEEERRLETEKAQQNEVGLKKQLEEALKEHRKVIEELKHAWQGFKEVLQAKDKELEVTKEEKEKAKAQKEEVVTQMTEVLESELQCSICSELFIEAVTLNCAHSFCQHCISEWRNRKDKCPMCWQNITSQTRSLVLDNCIDRMVENLSADMRERRLVLINERKGERSKSESISSSGGNK
What is the function of this protein?
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.  Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF).  H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates.  Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins.  In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.
What are the official names of this protein?
E3 ubiquitin-protein ligase rnf8, RING finger protein 8, RING-type E3 ubiquitin transferase rnf8.
What is the protein family that this protein belongs to?
Belongs to the RNF8 family.
What are the subcellular locations of this protein?
Nucleus. Note=Following DNA double-strand breaks, recruited to the sites of damage.
Protein: C28D1_DROME
Sequence: MCPISTALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLMQKCIQVRRESPAAQQRDDFLNYMLQLQEKKGLNAAELTSHTMTFLTDGFETTAQVLTHTLLFLARNPKEQMKLREEIGTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMPALKGGVWLDFVERN
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 28d1, CYPXXVIIID1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: MASZ_PSEAE
Sequence: MTERVQVGGLQVAKVLFDFVNNEAIPGTGVSADTFWTGAEAVINDLAPKNKALLAKRDELQAKIDGWHQARAGQAHDAVAYKAFLEEIGYLLPEAEDFQAGTQNVDDEIARMAGPQLVVPVMNARFALNASNARWGSLYDALYGTDVISEEGGAEKGKGYNKVRGDKVIAFARAFLDEAAPLESGSHVDATSYSVKNGALVVALKNGSETGLKNAGQFLAFQGDAAKPQAVLLKHNGLHFEIQIDPSSPVGQTDAAGVKDVLMEAALTTIMDCEDSVAAVDADDKVVIYRNWLGLMKGDLAEEVSKGGSTFTRTMNPDRVYTRADGSELTLHGRSLLFVRNVGHLMTNDAILDKDGNEVPEGIQDGLFTSLIAIHDLNGNTSRKNSRTGSVYIVKPKMHGPEEAAFTNELFGRVEDVLGLPRNTLKVGIMDEERRTTVNLKACIKAAKDRVVFINTGFLDRTGDEIHTSMEAGAVVRKGAMKSEKWIGAYENNNVDVGLATGLQGKAQIGKGMWAMPDLMAAMLEQKIGHPLAGANTAWVPSPTAATLHALHYHKVDVFARQAELAKRTPASVDDILTIPLAPNTNWTAEEIKNEVDNNAQGILGYVVRWIDQGVGCSKVPDINDVGLMEDRATLRISSQLLANWLRHGVISQEQVVESLKRMAVVVDRQNASDPSYRPMAPNFDDNVAFQAALELVVEGTRQPNGYTEPVLHRRRREFKAKNGL
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF3_SYNPW
Sequence: MPRSNRNDNFIDKSFTVMADLIVKLLPINARAKEAYVYYRDGLSAQNDGDYAEALENYEESLKLEENPIDRGETLKNMAIIYMSNGEEDRALATYQKALDENPKQPSCLKNMGLIFEKRGRTAEEEGRRDDADGWFDQAAEVWTQAVRLNPGGYLDIENWLKSTGRSNVDVYF
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.