PharMolix/UniProtQA huggingface dataset:
Protein: RLMN_ECOLI
Sequence: MSEQLVTPENVTTKDGKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.  Unmodified tRNA is not a suitable substrate for RlmN, which suggests that RlmN works in a late step during tRNA maturation.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_STAAR
Sequence: MIGIIGAMEEEVTILKNKLTQLSEISVAHVKFYTGILKDREVVITQSGIGKVNAAISTTLLINKFKPDIIINTGSAGALDESLNVGDVLISDDVKYHDADATAFGYEYGQVPQMPVAFQSSKPLIEKVSQVVQQQQLTAKVGLIVSGDSFIGSVEQRQKIKKAFPNAMAVEMEATAIAQTCYQFNVPFVVVRAVSDLANGEAEMSFEAFLEKAAVSSSQTVEALVSQL
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: YNG1_AZOBR
Sequence: STIQIDGDVVTRLLKGRDTAGNSVVIGVHKDAVDVSFRYWSFLIDALGRFAGKAVNTLVGDTG
What are the official names of this protein?
Uncharacterized protein in nodG 5'region, ORF 1.
Protein: CLPP_LIRTU
Sequence: MPIGVPKVPFRSPGEEDAIWVDVFNRLYRERLLFLGQEVDSEISNQLVGLMVYLSIEDDTRDLYLFINSPGGWVIPGISIYDTMQFVPPDVHTICMGLAASMGSFILVGGEITKRLAFPHARVMIHQPASSFYEAPTGEFILEAEELLKLRETLTRVYVQRTGNPLWVVSEDMERDVFMSAAEAQAHGIVDLVAVENTGDFA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RIMM_XANAC
Sequence: MKQNERRILLGRIVGAFGVKGELKLESWTEPRTAIFRYQPWIVRSPSGQESVVSGVRGRDQGKNLIAVFPGVTDRDTVEAMHGTEIYVARSALPPPKPDEYYWVDLEELQVETVEGVKLGTVSHLFSTGSNDVVVVRGDRERMIPFVFPDFVKSVDFEANLIVVDWDPDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_YERPB
Sequence: MFRGATMVNLDSKGRLAVPTRYRESLNEESQGQMVCTIDLHQPCLLLYPLPEWEIIEQKLSRLSSMNPAERRVQRLLLGHASECQMDGAGRLLIAGTLRQHAGLNKEVMLVGQFNKFELWDEQTWYQQVKDDIDAEQSTQEPLSERLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: YPR14_YEAST
Sequence: MSCIFSADLGVEYSCAESRITNLVLCILCIREEKAAPVVKKDKFLFFIFLSSKENLFCEISSRSSVSEVKSLRAKNNFICPHAVIGFQGAKAQLGIRFPQLNGLLRLQH
What are the official names of this protein?
Uncharacterized protein YPR014C.
Protein: RL10E_PYRNV
Sequence: MPVRPARCYKRIKGPPYTREEYIHGAPMIQIPKFDMGTTSAAARAAFPLVAKLVVQERGQIRMQALEAARQMAYKYLSKYVGDANYYLRLEAVPHHVLRENRMLAMAGADRLQEGMRLAFGSPAGRAARVEAGQVIFYAEFKPEHVAHMKEALRRASTKLPLPTRIVIEAKGDGGGKAATQG
What are the official names of this protein?
50S ribosomal protein L10e.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: CYSG_ALCBS
Sequence: MEFLPISWRLQGKVALLAGGGEVALRKGRLLHRSGAILTVVAPQVCDELLDIVVRSGGSCVVRAFESADLDGVALVICATDDRSTNAEIAKQAQQRGLPVNVVDDPSLGDFIFPAIVDRSPVLISISSSGASPVLARKLRAQLESTLPARWGRLADLMARFRQPLKDKLSNIGARRLFWEQTLDSPVVEKVLAGKDSEAEAMLAAAIESADATTLSRGEVYLVGAGPGDPDLLTFRALRLLQKADVVLYDRLVGKGIVDLARRDAELVYVGKARDKHALPQDNINELLVHYAKQGKKVCRLKGGDPFIFGRGGEEIDLIVAEGIDFQVVPGITAASGCASYAGIPLTHRDHAQSVRFVTGHRKDGSVDLDWKHLVSETETVVFYMGLVGLREICSQLIAHGRGGDTPIALVSRGTTNLQEVITGRLDQLPDDIEGREIHAPTLIIVGSVVSLHPKFGWFKP
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: PFKA_STAA9
Sequence: MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_DESHY
Sequence: MINDVLKEAEDRMVKAVEALKREYATIRAGRANPNMLDKITVEYYGTQTPVNQLANISVPEPRMLTIQPWDKSSLPMIEKAILKSDLGLNPSSDGTVIRLLIPQLTAERRTEIVKTVKKKAEDSRVAVRNIRRDSNDELKKLEKDHTASEDEVKRAQDDVQKMTDKFVKEIERIMGTKEKEIMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_BORA1
Sequence: MNANTPTPIDGQPTELTPSTQAALEPANHAPASPGATHIRSFVHRRGHITQRQRDALEQLMGKWAIPYAPRPLNPATAFGREAPTILEIGFGMGETTEKIALARPEDNFLGVEVFNAGVGSMLHRIETSQIPNVRIIQHDAVEVVRDMIAPDSLAGVHVYFPDPWPKKRHHKRRLLQPAFVQLLASRIKPGGYLHCATDWQDYAVQMLEVLGGEALLENTAQDYAERPAYRPQTKFETRGLRLGHGVWDLIFKRKA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: PSAM_CYACA
Sequence: MITDSQVFIGLVIALVPAILAFKLGLSLYE
What are the official names of this protein?
Photosystem I reaction center subunit XII, PSI-M.
What is the protein family that this protein belongs to?
Belongs to the PsaM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MOAP1_HUMAN
Sequence: MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLAPLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDPDNTFLSRLNEFLAGEGMTVGELSRALGHENGSLDPEQGMIPEMWAPMLAQALEALQPALQCLKYKKLRVFSGRESPEPGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESLRGPALDVIRVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEAAEEEEALLQAILEGNFT
What is the function of this protein?
Retrotransposon-derived protein that forms virion-like capsids (By similarity).  Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (PubMed:11060313, PubMed:16199525).  Required for death receptor-dependent apoptosis (PubMed:11060313).  When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (PubMed:15949439).  Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314).  Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (PubMed:33393215).
What are the official names of this protein?
Modulator of apoptosis 1, MAP-1, MAP1, Paraneoplastic antigen Ma4.
What is the protein family that this protein belongs to?
Belongs to the PNMA family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion outer membrane. Extracellular vesicle membrane. Note=Forms virion-like extracellular vesicles that are released from cells.
Protein: 3S166_MICAT
Sequence: MKTLLLTLVVVTIVCLDFGHTLICYNYETPLDKTTECCGNGVTTCFAKSWRDHRGLRTDRGCGCPNVKPGVTINCCKTDRCNG
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Three finger toxin MALT0066C, MALT0066C.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TLS1_PONAB
Sequence: MPVVRKIFRRRRGDSESEEDEQDSEEVRLKLEETREVQNLRKRPNGVSAVALLVGEKVQEETTLVDDPFQMKTGGMVDMKKLKERGKDKISEEEDLHLGTSFSAETNRRDEDADMMKYIETELKKRKGIVEHEEQKVKPKNAEDCLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDQGIDAKIKNIISTEDAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKPEPERSPPNRKRPANEKATDDYHYEKFKKMNRRY
What is the function of this protein?
Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (By similarity).  May also modulate exon inclusion events (By similarity).  Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (By similarity).  Binds U5 snRNA (By similarity).  Required for proper chromosome segregation (By similarity).  Not required for splicing of shelterin components (By similarity).
What are the official names of this protein?
Splicing factor C9orf78 homolog.
What is the protein family that this protein belongs to?
Belongs to the TLS1 family.
Protein: GLU2A_ORYSJ
Sequence: MDPPPRPRPHRVAVLLLLLLASSPAARAWKKDEFRNCNQTPFCKRARTRAPHSLDAPLSLDAASLAVATDGSLTASLSHPSRLRPLLLRLSALPPHALRLQIDEDYSSNTPPHRRFQVPDVLLPDVEARTLHLPQPKTSAAGVSTFALSSDVDVVVKHDPFELTVRRAGSGAPVLSFNSHGLFDFEPLQESKQEGETWEEQFRSHTDTRPRGPQSITFDVSFYGADFVYGLPEHGSTSLALRPTRGPGAEESEPYRLFNLDVFEYLHESPFGLYGSIPFMIAHGDGPSSGFFWLNAAEMQIDVLAPGWDGASSTENGRIDTLWMAEAGVVDAFFFVGSEPKDVIKQYISVTGTPSMPQQFAVAYHQCRWNYRDEEDVAGVDSGFDEHDIPYDVLWLDIEHTDGKRYFTWDHSAFPNPEVMQGKIADKGRKMVTIVDPHIKRDSSFHLHEEATAKGYYVKDATGKDFDGWCWPGASSYPDMLNPEIREWWADKFSYENYKGSTPTLYIWNDMNEPSVFNGPEVTMPRDAVHYGDVEHRELHNAYGYYFHMATADGLLKRGEGKDRPFVLSRAFFAGSQRYGAIWTGDNSADWDHLKSSIPMVLTLGLTGMTFSGADIGGFFGNPEPDLLVRWYQVGAFYPFFRGHAHHDTKRREPWLFGERRTALMREAIHMRYSLLPYYYTLFREASVTGVPVMRPLWLEFPDDKETYNNGEAFMVGPSLLAQGIYEEGQKSVSVYLPGEELWYDLRNGSPYKGGVSHKLEVSEDSIPSFQRAGAIVPRKDRFRRSSTQMVNDPYTLVIALNSSSAAEGELYVDDGKSYDYQQGAFIHRRFVFADNKLTSMNIAPKNLGNKKFSTECVIERIIILGVSSGSKKAIVEPGNHEVDIELGPISLRSGSSSVAPTVRKPNVRVVDDWTIRIA
What is the function of this protein?
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.  May be required for defense response elicited by pathogen-associated molecular patterns (PAMPs).
What are the official names of this protein?
Probable glucan 1,3-alpha-glucosidase, Glucosidase II subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 31 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: EFP2_CHLMU
Sequence: MVRVSTSEFRVGLRVEIDGQPYVILQNDFVKPGKGQAFNRIKVKNFLTGRVIEKTFKSGESIETADVREQQMRLLYTDQEGATFMDDETFEQELIFWDKLENIRQWLLEDTVYTLVRYNGDVISVEPPIFMELSIAETAPGVRGDTASGRVLKPATTNTGAKIMVPIFIEEGEVVKVDTRTGSYESRVSK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
What are the official names of this protein?
Elongation factor P 2, EF-P 2.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_STAAR
Sequence: MAQVEYRGTGRRKNSVARVRLVPGEGNITVNNRDVREYLPFESLILDLNQPFDVTETKGNYDVLVNVHGGGFTGQAQAIRHGIARALLEADPEYRGSLKRAGLLTRDPRMKERKKPGLKAARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: FPG_AGRVS
Sequence: MPELPEVETVKRGLAPSMEGRRLTRLELRRTDLRFPLPVDFAARTQGRLIVSLSRRAKYLLIDLDDGVSIVSHLGMSGSYRIEAANETGLPGQFHMARSRDEKHDHVIFHLSGPEGDPLRVIYNDPRRFGFMDMVERRHMDRHAAFAGLGPEPVGNALDADYLAFRFKGKAQPLKTALLDQKVIAGLGNIYVCEALWRAHLSPETPARALVNAEGKPVAALEDLTQAIRTVIAEAIEAGGSSLRDHIQADGSLGYFQHSFNVYDREGEACRTPGCTGTVERMTQAGRSTFHCPQCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: H2B_PLADU
Sequence: MPPKVASKGAKKAASKAKAARSGEKKKKRRRRESYSIYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SYA_CLOBA
Sequence: MKFTKTNDLRDAYLKFFESKDHLKLESFSLVPQNDKSLLLINAGMAPLKPYFTGLQEPPKKRITTCQKCVRTGDIDNVGITSRHGTFFEMLGNFSFGDYFKKEIIPWAWEFLTGVLELPKEKLYVTIYLDDDEAYEYWTTLTDVDKTHIFRLGKEDNFWEHGAGPCGPCTEIHFSRTDEVPTNSEKFVELSDEDKIIEVWNLVFTQFDGDGKGNYEKLASTNIDTGMGLERLAVVMQNKNSIFEIDTLENILKEVGNLANVKYGEDNKIDVSLRIITDHIRSITFMISDDIMPSNEGRGYVLRRLLRRAARHGKTLGIKDAFLCNLCDVVIRDCGSAYSDLEAKKDYIKKVIKIEEDKFRETLDSGMEILNNLISELKENNEKVLKGADGFKLYDTFGFPMELTKEILEDEDLSLDEDGFHKEMKEQRERARSARKTSNYMGTDVKTLDVISGEIETTFDGYENDSLIAEVKTLVNGEDFTNSIIEGNNAVVVTDVTPFYAEMGGQIGDTGTIYNDNFKGKVLDTKKNIGGKIIHFVEAISGELKVGDKVKLEVDNARRENIKRNHTATHLLDAALVKVLGSHVHQAGSYVSADRLRFDFSHFEGVKEEELLKVEQLVNEAIMSVTPVNTTEMDLQEAKNSGAVGIFDDKYAEKVRVVCAGEYSKELCGGTHIDNTGKIGLFKIISENGIAAGTRRIEAVTGIEAYKWVNEKAELLKHISGKLKCSEKEITIKLDQQSKEIKEKEKEITNLKSKFASMEINDIINSVKDVKGINVVTYALTDVDGEALRGLCEKVRDKVNNSLTLLTSSIDGKVVICAMADKEAVSKGAHCGKVIKEAATILGGGGGGRPDMAQAGGKLPEKISDALDSVYKIVETLVK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MKNK1_XENLA
Sequence: MVSSQPVPFDDGGKRRKKKRKTRAMESFTGKFADLYRLTDELLGEGAYAKVQGCVSLQNGKDYAVKIVEKKAGHSRSRVFREVETLYQCQGNKNILELIEFCEDDARFYLVFEKLLGGSILSHIQKRKHFNEREASKVVKDIASALDFLHTKGIAHRDLKPENILCEFKDKVSPVKICDFDLGSGVKLNSACTTITTPELTTPCGSAEYMAPEVVEVFTEEATFYDKRCDLWSLGVILYIMLSGYPPFVGNCGTDCGWDRGEVCRVCQNKLFESIQEGKYEFPEKDWSHISISAKDLISKLLVRDAKERLSAFQVLQHPWLQGDAPERGLPTPLVLQRNSSTKDLTIFAAEAIAFNRQLSQHDNDLNEEDESFIHAVCSMRLSPPSKSRLAKRRAQAHARKGGSHPTHSTVTASQGTP
What is the function of this protein?
May play a role in the response to environmental stress and cytokines.  Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).
What are the official names of this protein?
MAP kinase-interacting serine/threonine-protein kinase 1, MAP kinase signal-integrating kinase 1, MAPK signal-integrating kinase 1, Mnk1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Protein: PG161_VAR67
Sequence: MMTPENDEEQTSVFSATVYGDKIQGKNKRKRVIGICIRISMVISLLSMITMSAFLIVRLNQCMSANEAAITDATAVAAALSTHRKVASSTTQYKHQESCNGLYYQGSCYIFHSDYQLFSDAKANCATESSTLPNKSDVLTTWLIDYVEDTWGSDGNPITKTTTDYQDSDVSQEVRKYFCVKTMN
What is the function of this protein?
Forms a complex with OPG162 and OPG190 to coordinate the incorporation of OPG164 into wrapped enveloped virion (EV) membranes and, subsequently, the production of actin tails.  Therefore plays an essential role in efficient cell-to-cell spread of viral particles.
What are the official names of this protein?
Protein OPG161.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG161 family.
Protein: FDHE_YERE8
Sequence: MSIRIVPKDQLGKQSEKGTTAGNIPPLLFANLKSLYTRRTERLQQLALDNPLADYLDFAAKITQAQQKALHDHPLVLDMQAELAQSAASGKPPLDLSVFPRTDHWRKLLSALIAELRHDAPDHIVAVLDNLDKASVHELELYADALLNREFAQIGSEKAPFIWAALSLYWAQMASQIPGKARAEYGEHRQFCPVCGSIPVSSVVHIGTQNGLRYLHCNLCESEWHVVRIKCSNCEQTRDLNYWSLDTELAAVKAESCGDCGTYLKILYQEKDPMVEAVADDLASLILDAKMEGEGFARSSINPFLFPGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE homolog.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URK_SALPB
Sequence: MTDQSHQCVIIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLQALKRGSAIELPVYSYVEHTRMQETVRVEPKKVIILEGILLLTDARLREEMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCDB_METMP
Sequence: MILSDKDIFNYVTSKRVLIEPFNSKFVGPCSYDVTLGSEFIKYNEDVYDVKKTLNHSKFKIENSVMVCPLNHHLDETIIKNYKEKYNVDCVVSGGLLGTTNEYVELPNDVCAQYQGRSSFGRVFLQTHQTAGWIDSGFKGKITLEIVAYDKPVILYKNQRVGQLIFSKTLSPADIGYSDRKCSKYAGQTSVMASLIKKDFETNEEE
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: USP6_PINMG
Sequence: MLFRFLSVRAVFFLAVFSVVILWTYACDCPDETRQQKCRRTDFTFLGNANFVALTSVQSSLYIRYCFSIWRVFKDRSFALSSPCIVTPFDTIACGIRIQLYEPYIVSGVHTRSGNIAQACDWNERWSDVPFFYRFQVLNQPDYCLP
What are the official names of this protein?
Uncharacterized shell protein 6, Prism tissue inhibitor metalloproteinase protein 3.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2857_SHESH
Sequence: MSEQAKVGLGLRREMLDEFCDSTPDAIDFFEVAPENWMTLGGKFGRQFKQLTERKPFFCHGLSLSIGGPSPLDIQFVKDIKAFMDLHNISTYSEHLSYCSGTGHMYDLMPIPFTQEAVMHVVKRVKQVEDILERPLILENVSFYAAPGAEMTEFEFVNAVLSEADCRLLLDVNNIYVNSVNHHYDASQFLGSMPTERIAYLHIAGHYEEAEDLIVDTHGADIISPVWQLLRECYEIHGVHPTLLERDFNIPPTSELLNEIDQIHEYQHAVPSLLSRSA
What are the official names of this protein?
UPF0276 protein Ssed_2857.
What is the protein family that this protein belongs to?
Belongs to the UPF0276 family.