PharMolix/UniProtQA huggingface dataset:
Protein: SARNP_HUMAN
Sequence: MATETVELHKLKLAELKQECLARGLETKGIKQDLIHRLQAYLEEHAEEEANEEDVLGDETEEEETKPIELPVKEEEPPEKTVDVAAEKKVVKITSEIPQTERMQKRAERFNVPVSLESKKAARAARFGISSVPTKGLSSDNKPMVNLDKLKERAQRFGLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEAKKRKRAERFGIA
What is the function of this protein?
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form.  Specifically binds to scaffold/matrix attachment region DNA.  Also binds single-stranded RNA.  Enhances RNA unwinding activity of DDX39A.  May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis.  Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA.  TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.  The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
What are the official names of this protein?
SAP domain-containing ribonucleoprotein, Cytokine-induced protein of 29 kDa, Nuclear protein Hcc-1, Proliferation-associated cytokine-inducible protein CIP29.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: DNAJ_HALMA
Sequence: MSQDFYEILGVSRDASEDEIQEAYREKAREYHPDVSDDPDAEEKFKQAKKAKEVLTDEEKRQMYDQMGHERFEQAEKRGGAGGGGGRGGMGGDPFGGGAGGFDMQDIFDQFFGGGGRGGRGGSRRRQGQDLQTRLEIDLEEAYNGATKQLNVTRPEACDDCDGAGHPPGADSETCPECNGQGQTTQVQQTPMGRVQQRTTCRRCDGEGTLYDETCSTCRGNGVVQNDASLEVEIPSGIADGQTLRMEREGAPGENGGPNGDLLIEVQVRDHPDFERDGDSLQHQQAISFPQAVFGDTITVPTLDGEVEVDVPSGTQSGEVFRLEGKGMPRLRRRGHGDLYVQVQVVTPDSLNAEQKEALEQFAEAGGEEVDVDEGFFEKLKNSL
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HLDE_ECOL6
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQLDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: QOX2_STAES
Sequence: MSKFKSLLLLFGTLILLSGCSNIEVFNAKGPVASSQKFLIIYSIIFMLVIVAVVLSMFAIFIFKYSYKKNSESGKMHHNSLIETIWFVVPILIVIALAIPTVKTLYDYEKPPEKDKDPLVVYAVSAGYKWFFAYPDQHIETVNTLTIPKDRPVVFKLQSMDTMTSFWIPQLGGQKYAMTGMTMNWTLTADQLGTFRGRNSNFNGEGFSRQTFKVHSVSQNDFDKWVKEAKGKKTLSQDTFDKQLLPSTSNKELTFSGTHMAFVDPAADPEYIFYAYKRYNFEQKDPNFTAEEDLYKDVKDKPIKPARKVHITNPNYERHGMKPMILGNNEKYDNEFKKEEDHNSKEMEKISKGAKDENASKLHKKEHDDHGGGH
What is the function of this protein?
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.  Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I (By similarity).
What are the official names of this protein?
Probable quinol oxidase subunit 2, Quinol oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1218_PSEPF
Sequence: MSTAICPCGSGNLLDACCGHYHAGHPAPCAEALMRSRYSAYVLGLIDYLVATTLPAQQAGLDRQSISNWSAQSTWLGLDVESSEVLGGQPEHAFVTFTARWHDGQGEHSHRERSSFVQNSGRWYFIDPTVQLKLGRNDACPCASGQKFKKCCAGYFGS
What are the official names of this protein?
UPF0225 protein Pfl01_1218.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: RXLRK_PHYIT
Sequence: MRFYSVLLTIVTLIASTYDAKVNASGIQAIAVSSISHDAPAARMLRADHADERGISVPSASKIVEWMLSPKVAKELTFLENRKVQKWVDKQKTQEYVFTKLGLNSGLDKALSNPKLHVYAAYIDRFNVKNPSNKVALLDKFSEKYTDEGVAKMVEMGIRSSNLETENFASRLWRELLNKWMDNAESAEGVFKILKLDEVGGGIFVTPLFNTWYAFIKEGYTRQAEDVVLRVLSDRYGYDGLSRIFFRGQRNFDLVGDLPIKLETRMVNNWLNKDVSPDKVFKLLKLDEGLDKLLTNSNMQVWESYMMKYNLMPDVEPTTMMQTITRFYNFKELSSMLENAKMVPELNKVAERWQHELRVHYLRAPKMKKEG
What is the function of this protein?
Effector that enhances P. infestans colonization of Nicotiana benthamiana leaves.
What are the official names of this protein?
RxLR effector protein PITG_12731.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Host cytoplasm.
Protein: RECX_ENTFA
Sequence: MTTITRISKDKGEFYLLWLSSGEKLRVSEDILVRQRLLKGQELSDTLIEEIKKASSYDVGLQMAMNYLSYQLRSKKEIFTYLKEKEIVPEDRVKIVQRLEELRLLDDAIFSESYVRTAMRTSDKGPRNVAQQLKQKGISEEDIQHGLTFYTLDEQLNVATATAEKAMKRYRTKSFKDALQKMRLHLMQKGFTNEIIDLALESLAFEKDEEQEQQALDKEGERLWRANQRFDFSKKVQKVKQSLFQKGFDYDLIQQFISEKEVEHDE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SODM_STRA5
Sequence: MAIILPDLPYAYDALEPHIDAETMTLHHDKHHATYVANANAALEKHPEIGEDLEALLADVSQIPEDIRQAVINNGGGHLNHALFWELMSPEETQISQELSEDINATFGSFEDFKAAFTAAATGRFGSGWAWLVVNAEGKLEVLSTANQDTPIMEGKKPILGLDVWEHAYYLNYRNVRPNYIKAFFEIINWNKVNELYQAAKA
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.  Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site.
What are the official names of this protein?
Superoxide dismutase [Mn/Fe].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: XERDL_STRU0
Sequence: MIKHIEAFLASKTISENTLKSYRYDLNQFLMLIDHKLSDEKLVLYQKSLNHLSASAKKRKFSTVNQFLHYLYKVNVTDRFFELSGKVSLPSTKVPFTYQLDDKRFYQKTQHPSGQLIALLILELGLLPSELSKLRLSEIDLDFQLIRVDNGSTVKVLSFSQAILKHLSEMEVGSTYLFENKGKPYSRQWFFNQLNAFLLEIGYDQLSAQSLREQFIIREKEKGTSLMELTQKLGLKSPITLEKYYRL
What is the function of this protein?
Putative tyrosine recombinase.  Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site.
What are the official names of this protein?
Tyrosine recombinase XerD-like.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD-like subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACOX2_YARLI
Sequence: MNPNNTGTIEINGKEYNTFTEPPVAMAQERAKTSFPVREMTYFLDGGEKNTLKNEQIMEEIERDPLFNNDNYYDLNKEQIRELTMERVAKLSLFVRDQPEDDIKKRFALIGIADMGTYTRLGVHYGLFFGAVRGTGTAEQFGHWISKGAGDLRKFYGCFSMTELGHGSNLAGLETTAIYDEETDEFIINTPHIAATKWWIGGAAHTATHTVVFARLIVKGKDYGVKTFVVQLRNINDHSLKVGISIGDIGKKMGRDGIDNGWIQFTNVRIPRQNLLMKYTKVDREGNVTQPPLAQLTYGSLITGRVSMASDSHQVGKRFITIALRYACIRRQFSTTPGQPETKIIDYPYHQRRLLPLLAYVYALKMTADEVGALFSRTMLKMDDLKPDDKAGLNEVVSDVKELFSVSAGLKAFSTWACADVIDKTRQACGGHGYSGYNGFGQAYADWVVQCTWEGDNNILTLSAGRALIQSAVALRKGEPVGNAVSYLKRYKDLANAKLNGRSLTDPKVLVEAWEVAAGNIINRATDQYEKLIGEGLNADQAFEVLSQQRFQAAKVHTRRHLIAAFFSRIDTEAGEAIKQPLLNLALLFALWSIEEDSGLFLREGFLEPKDIDTVTELVNKYCTTVREEVIGYTDAFNLSDYFINAPIGCYDGDAYRHYFQKVNEQNPARDPRPPYYASTLKPFLFREEEDDDICELDEE
What is the function of this protein?
Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons.  Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group.
What are the official names of this protein?
Acyl-coenzyme A oxidase 2, Acyl-CoA oxidase 2.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA oxidase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: STYC_PSEFL
Sequence: MLHAFERKMAGHGILMIFCTLLFGVGLWMHLVGGFEIIPGYILEFHVPGSPEGWARAHSGPALNGMMVIAVAFVLPSLGFADKKPHLLGNIIILDGWANVGFYFFSNFSPNRGLTFGPNHFGPGDIFSFLALAPAYLFGVLAMGALAVIGYQALKSVGSRKAVPHATAE
What is the function of this protein?
Epoxystyrene isomerase that catalyzes the second step in the aerobic styrene degradation pathway by converting epoxystyrene to phenylacetaldehyde.
What are the official names of this protein?
Styrene-oxide isomerase.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NUOB_ROSDO
Sequence: MTVATNVNAAGVDREVATQELNRELQDKGFLLTSTEDIINWARTGSLHWMTFGLACCAVEMMHTAMPRYDMERFGTAPRASPRQSDLMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALLYGIMQLQRKIRRTGTIVR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DAPE_SHEFN
Sequence: MNNDVVELAKDLISRPSVTPLDEGCQTLMANRLAAVGFNIEPMVFEDTTNMWARRGNCDPVFCFAGHTDVVPTGDLNRWHTPPFEPTIIDNYLHGRGAADMKGSLAAMIIATERFVAKHPDHNGSIAYLITSDEEGPFINGTTRVIDTLEARNEKMTWALVGEPSSTHKLGDVVKNGRRGSLTGNLTVNGIQGHVAYPHLADNPIHKAVPALTELAQMHWDNGNEFFPPTSFQIANINGGTGASNVIPGELTVMFNFRYSTEVTAEELILRVVSILDAHGLDYDINWIFNGLPFLTGDGPLLDATREAIREVTGYETDPQTSGGTSDGRFIAPTGAQVLELGPVNATIHKVNECVNVADLEILANCYERILEKLLCK
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: 3SOC1_MICCO
Sequence: MKTLLLTLVVVTIVCLDFGYTIVCYKRHASDSQTTTCLSGICYKKITRGISRPEMGCGCPQSSRGVKVECCMRDKCNG
What are the official names of this protein?
Alpha-neurotoxin homolog 1, NXH1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group XII sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CP2E1_PIG
Sequence: MTALGITVALLVWLVTLLLISIWKHIHSSWKLPPGPFPLPIVGNIFQLDLKNIPKSFTMLAERYGPVFTVYLGSRRIVVLHGYKAVKEVLLHYKNEFSGRGEIPTFQVHKDKGVIFNNGPTWRDTRRFSLTTLRDFGMGKQGNEQRIQREAHFLLEALRKTHGQPFDPTFLIGCAPCNVISDILFRQHFDYNDKTCLRLMSMFNENFYLLSTGWIQLYNNFSGYLRYLPGSHRKLMKNISEIKDYALERVKDHRDSLEPSCPRDFTDTLLMEMEKEKYSAEPIYTLDNIAVTVADMFFAGTETTSTTLRYGLLILMKYPEVEEKLHEEIDRVIGPNRIPAIKDRLVMPYLDAVVHEIQRFIDLIPSNLPHEATRDTDFRDYIIPKGTVVIPTLDSVLYDSQEFPEPEKFKPEHFLNENGKFKYSDHFKAFSAGKRVCVGEGLARMELFLFMAAILQHFNLKSLVDPKDIDLSPIAIGFAKIPPHYKLCVIPRSQV
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids.  May be involved in the oxidative metabolism of xenobiotics.
What are the official names of this protein?
Cytochrome P450 2E1, 4-nitrophenol 2-hydroxylase, CYPIIE1, Cytochrome P-450-J, Cytochrome P450-J.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Note=Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein.
Protein: SOMA_FELCA
Sequence: MAAGPRNSVLLAFALLCLPWPQEVGTFPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRGGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
What is the function of this protein?
Plays an important role in growth control.  Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1.  It stimulates both the differentiation and proliferation of myoblasts.  It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y3666_EDWI9
Sequence: MIIPWQQIAPETLDSLIEAFVLREGTDYGEQERSLTQKVEDVRHQLKCGEAVVVWSELHESVNIMPRSQFNGVD
What are the official names of this protein?
UPF0270 protein NT01EI_3666.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: PIS_YEAST
Sequence: MSSNSTPEKVTAEHVLWYIPNKIGYVRVITAALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCFLCVQYPQWCVFFQLMLGLDITSHYMHMYASLSAGKTSHKSVGEGESRLLHLYYTRRDVLFTICAFNELFYAGLYLQLFSNSATFGKWTTIISFPGYVFKQTANVVQLKRAALILADNDAKNANEKNKTY
What is the function of this protein?
Catalyzes the synthesis of phosphatidylinositol (PtdIns).
What are the official names of this protein?
CDP-diacylglycerol--inositol 3-phosphatidyltransferase, Phosphatidylinositol synthase, PI synthase, PtdIns synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: YNBE_SHIFL
Sequence: MKILLAALTSSFMLVGCTPRIEVAAPKEPITINMNVKIEHEIIIKADKDVEELLETRSDLF
What are the official names of this protein?
Uncharacterized protein YnbE.
Protein: SECD_HALVD
Sequence: MSTLRDNWRVIFLVAAILLSTFALFSPTMGNQSPIGEDDSATNLQFGLQLDGGTRIRAPLVGVTAEDVEFEGDSERVVERQVAAQIAGADAADIIVRTGAESSTVEATIENVTADDLSAALDAAGYAHGEVRDGVTGTTRAETVRVLQSKINEAGLSGGTVQQVTTATGEHFILVEVPNRDQSDVVDLVGERGTVQIDIYYPTGTDNGSRTYETREAVLTQADFTSIGTAQESQTGSGAFVPVSVRDDPAAEFQTAIQDTGLAQPGGTRCTYMEDGGRNTTEGCLLLVVNGEVVNAFGMSGGLADTMRAGEWAGAPSFQLQTRNTSEAQEIAINLRAGALPARLDLSGEDSGTSSYISPSQGESFKFDSLITGIVAVLAVAGVVFIRYGKPQVALPMIVTGLSEVYILLGFAAAIGYPLDLSVIAGFIAVIGTGVDDLIIIADEVMGEGSVKSRKVFQSRFRRAFWVIGAAAATTIIAMSPLAVLSLGDLQGFAIFTILGVIVGVLVTRPAYGDILRLLLTEDR
What is the function of this protein?
Involved in protein export.
What are the official names of this protein?
Protein-export membrane protein SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ESA1_ASPOR
Sequence: MGVRDSHGEATATPDPVEKGFATLNTIRIGVKAMVQKDGELRKAEILSIRQRKDGPSFYVHYVDFNKRLDEWIDSTRIDLSHEVEWPQPEKPEKKKAGPGNKAPSKNAQKRARAGSREVSATPDLLTGKNTNIGKAQRPSKAGGKENRDETPANLSVLDSEAISADVTPKPEMEDVDMIGVSFTDTKEEHEQGKMSREEEIERLRTSGSMTQNPTEIHRVRNLNRLQMGKFDIEPWYFSPYPASFSDVDMVYIDEFCLSYFDNKRAFERHRSKCTLVHPPGNEIYRDDRISFFEVDGRRQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMATRDETGCHLVGYFSKEKDSAEGYNLACILTLPQYQRLGYGRLLIAFSYELSKREGKLGSPEKPLSDLGLLSYRQYWRETLVELLIEPGRESMSENELAVLTSMTEKDVHETLVVFNMLRYHKGNWVIVLTDQVVEQHNKRLEKEKIKGSRKIDPARLQWKPPVFTASSRTWNW
What is the function of this protein?
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A. Z (By similarity).  Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity).  The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation.  The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity).  Recruitment to promoters depends on H3K4me.  Also acetylates non-histone proteins (By similarity).  In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
What are the official names of this protein?
Histone acetyltransferase ESA1, Protein 2-hydroxyisobutyryltransferase ESA1, Protein acetyltransferase ESA1, Protein crotonyltransferase ESA1.
What is the protein family that this protein belongs to?
Belongs to the MYST (SAS/MOZ) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Following DNA damage, localizes to sites of DNA damage, such as double stand breaks (DSBs).
Protein: GSIA_SHISS
Sequence: MPHSDELDAGNVLAVENLNIAFMQDQQKIAAVRNLSFSLQRGETLAIVGESGSGKSVTALALMRLLEQAGGLVQCDKMLLQRRSREVIELSEQSAAQMRHVRGADMAMIFQEPMTSLNPVFTVGEQIAESIRLHQNASREEAMVEAKRMLDQVRIPEAQTILSRYPHQLSGGMRQRVMIAMALSCRPAVLIADEPTTALDVTIQAQILQLIKVLQKEMSMGVIFITHDMGVVAEIADRVLVMYQGEAVETGTVEQIFHAPQHPYTRALLAAVPQLGAMKGLDYPRRFPLISLEHPAKQAPPIEQKTVVDGEPVLRVRNLVTRFPLRSGLLNRVTREVHAVEKVSFDLWPGETLSLVGESGSGKSTTGRALLRLVESQGGEIIFNGQRIDTLSPGKLQALRRDIQFIFQDPYASLDPRQTIGDSIIEPLRVHGLLPGKDAAARVAWLLERVGLLPEHAWRYPHEFSGGQRQRICIARALALNPKVIIADEAVSALDVSIRGQIINLLLDLQRDFGIAYLFISHDMAVVERISHRVAVMYLGQIVEIGPRRAVFENPQHPYTRKLLAAVPVAEPSRQRPQRVLLSDDLPSNIHLRGEEVAAVSLQCVGPGHYVAQPQSEYAFMRR
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Glutathione import ATP-binding protein GsiA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Glutathione importer (TC 3.A.1.5.11) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RECO_BIFAA
Sequence: MPLYQDEGVVLRTAKLGEADRILTLLTRDHGKVRAVAKGVRRTKSRFGGRLEPFMRVALLIAEGRSLDVVSQAESIAAYAGPICADFQAYTAANVICETADKLVATEKEPAVAQYRLVLGALNALAKHAHEPSTIGDSYVLRALAIAGWTPRLRVCVVCGEPISSALSWYFSIPAGGLMCAADHTPESEAVSWDAICRLSALVDGDWGELDGVPASASIQRETHQIVEEWGEYYLERPIRSMRLLD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: TI214_NANDO
Sequence: MIFNSFLLGNLLSLCMKIINSVVVVGLYYGFLTTFSIGPSYLFLLRARVMEEGTEKEVSATTGFITGQLMMFISIYYAPLHLALGRPHTITVLVLPYLLFHFFWNNHKHFFDYGSTTRNSMRNLSIQCVFLNNLIFQLFNHFILPSPTLARLVNIYMFRCNNKMLFVTSSFVGWLIGHILFMKWVGLVLFWIRQNRSIRSNKYLVSELRNSMARIRIFSILLFITCVYYLGRIPSPIVTKKLKETSKTEEREESEEETDVEIETTSETKGTKQEQEGAAEKEVKDDKDLFWFEKPLVTLLFDYKRWNRPLRYIKNERFENAVRNEMSQYFFYTCISDGKQRISFTYPPSLSTFFEMIQKKLFLCTTEKISSEELYNHWAYTNEQKRNNLSKEFINRIETLDEGSLDLDILEKKTRLCNDENEQKCLPKIYDPFLNGPHRGTIQNLYSHSSMNNLLITSIKDSIKTLWINKYQGILDTDCREFEKEFAEEPMPNLNLKSPSSQGKFYSENQSKNFFDAATTYPNDQTIIDIEESLEINEIKKTVPRWLYKLTDDLEEEEIENDEESKPDHGIRSRKAKRVVIFTDNEKNQNTPTSTTETTSTAETTSTTETTSTTKNTSTTKNTSTTETTSTTENENTSNQDQSDEVALTRYSQQPDFRRDLIKGSMRAQRRKTVTWELFQATVRSPLFLDRVDKTFFFSFDISGTLKYFFRNWMGKDAEFKISNSEEEDTKEKEKKREEKRQENERIRISETWDTIIFAQAIRGYMLVTQSILRKYIVLPSLIIAKNIGRMLLFQFPEWHEDLKAWNKEMHVKCTYNGVQLSEKEFPKNWLTDGIQIKILFPFCLKPWHRSKVQFDHRDPMKKKGKPENFCFLTVWGMEAELPFGSPRKRPSFFEPIWKEIEKNIIKMKKKCFIALRILKERTKWFIRVSKEKTRWVIKIFLFIKRIMKELAKAKVSPIPLFGLREIDESSINTNQKYYINIKSNQIIHESPIRIRSLDWINYSLTAKKIKDVVDRTSTIRNQIEKITKDKKKLFLTPDRNINPNKIGCDDKGLESLKKIWQKLKRRSNRLIRKCYYFLKFFIERIYTDILFCIINSLRIKVKLFLEAKNKLFYKNSSNDETNKKGIDETNPNTIHFISTIKKSLSNINNSNNNSQIFCDLDSLSQAYVFYKLSQTQVFNKYHLRSVLQYRGTLLFLKDRIKDSFGTQGIFHSESGHKKLRNFRMNEWKNWLRGRYHYQYDFSQTRWSRLVPQKWRNRIHQRCMVQTKNSTYSDLYEKDQLIHYEKQNNYAVELNQKDKFKNYKYDKYDRLSHKYIHYEDKKDSYIYRSPLQVNEAKEFLYNYNTYNYSTYNPKLFFMSGDISLNNYLREDSDTEKNLDRKYFDWKIFNFCLRTKIDIEYWTNMDIGANVNKKTKTQTNYYQIIDKKDLFSIAIHKQINPAKQTKTSFDWMAMNEEILNCPISNLELWFFPEFVSFYNAYKIQPWTIPINLLLLNFNGNENVSEKQNINGKEKKDLPILSKSNQKKSLELKNKEEKKKPAQENIGSDTQKQGNPGSDPSTQQKDIKKNVKEDYDGRSDIQKRKKKKQSTGNIAAELDLFLKRYFLFQLRWDNPLNKKIINNVKVYCLLLRLKNPKEIAIASIQRDEMSLDVMPISKTLTLAKLINKGMLIIEPARLSIKRDGQFLLYQTITISRVHKNKHQTNQRYQEKRNVDKNGLEKSIARHEKLVGNRDKNPLLVLENILSSQRRRELRIRICLNSGNVNVVDRNPVFCNGNNASNCDQFLNEERHLDIDTNKFLKFKLLLWPNYRLEDLACINRYWFDTNNGSRFSMSRIRMYPQLRIS
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: RS4_GLUDA
Sequence: MSKRLESKYKINRRLGVNLWGRAKSPVNKREYGPGQHGQRRKQKPSDFSVQLMAKQKLKGYYGNISEKQFRKYYDEAVRRKGDTSENLIDLLERRLDAVVYRLKFAMTPFAARQFVSHGHITVNGRKVNIPSYIVRDEDVIEVREKSKHLAIVLDAAQSGERDVPEYMEVDHRQMKGRFLRAPKLSDVPYPVQMEPNLVIEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.