PharMolix/UniProtQA huggingface dataset:
Protein: CP142_MYCTO
Sequence: MRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPLG
What is the function of this protein?
Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection.  Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate.  Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
What are the official names of this protein?
Steroid C26-monooxygenase, Cholest-4-en-3-one C26-monooxygenase, Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming], Cholesterol C26-monooxygenase, Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming], Cytochrome P450 142, Steroid C27-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: SYFA_RICBR
Sequence: MDNIETILRLAEEKILLVQSLKVLQEYKVEFLGKNGIVTNELKKLGSLSEQDRKEFGLKINKLKEEIQNIIKAKEEILEEEELNLKLSSDKIDLSLPARRYKQGSIHPITQCMEELIQVFAKFGFSIEDGPNIENDFHNFTALNFEDDHPARQMHDTFYLKGQENDKPMLLRTHTSTVQIRAMKNGKPPFRFIAPGRTYRSDSDMTHTPMFHQIEGLVIDKDINMGHLKYVITEFIRCFFENSNIELRFRPSFFPFTEPSAEVDIRMSKTDKWLEVLGCGMVHPNVLKNVGIDNSQYQGFAFGLGVERFAMLKYNIKDLRQFFEGDMRWLKHYSFSSFDIPNLAGGLTK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DF180_ARATH
Sequence: MERITSLVFFASFLIIFVSGVNQTRADSCDESLGLCETCDERCQAKHGPSCISKCDGEVGMLSCTCTYECGPPLPPKGNVCSGGTGMCSGKCPYKCCDTSCAQKYNGGRGFCNSFGNYNFCQCEYPC
What are the official names of this protein?
Putative defensin-like protein 180, Putative low-molecular-weight cysteine-rich protein 58, Protein LCR58.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAA_HELHP
Sequence: MKLKILHFTSGNKLHIDNILKKLKSKLSEFEYQFYISLMEYDENASRTDMKVFYVPNIFVANWIKSNHLESIIDAFEEESNNGVRPEIHIKVKEKKENVKSLKNNKSMLYFNTNGLSLNPFYTFENFVVGKSNEYAYTIAKLVLQQQASAYNPVLLYGKSGLGKTHLLNAIGNDVKEKNKNVLYVTSEDFLNDYMDKIKRKTMDSFRDKYRKCDYLLIDDVQFFGGKEGIQEELLHTFNTLHNSQKQIVMTSDKPPKEIKGLEERLRTRFEWGAMAEITNPELETKIAIIKSKCEVNRIVLENEVIDYIASNIYGNIRQIEGILSTINAHINLSPESSSLKIAKNVLKNYQIEKLEGITLDNIIKVVSKELNIKPSEIVSKERNRKVTFARRAVIYLAHSLMINSMNIIAKELGMKDHSSVSKALKAIKKEIAENSTTRNIIEDMKSKIQQSLDSV
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_ECO7I
Sequence: MAKTLYEKLFDAHVVYEAENETPLLYIDRHLVHEVTSPQAFDGLRAHGRPVRQPGKTFATMDHNVSTQTKDINACGEMARIQMQELIKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGKDFDDAVAYWKTLQTDEGATFDTVVTLQAEEISPQVTWGTNPGQVISVNDNIPDPASFADPVERASAEKALAYMGLKPGIPLTEVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRNIK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: MOAA_VIBC3
Sequence: MERCSVAQQFEDRFQRKFYYLRLSITDVCNFKCTYCLPDGYKPSAGRPASFLTVNEIRRVVSAFAHCGTSKVRITGGEPSLRKDFGEIIHTIAQTPGIQKVATTTNGYRLAKHIGEWREAGLTQLNVSVDSLDPRMFAQITGENRFQQVMSGIDRAFEVGFEQVKVNVVLMKNLNHLELPQFMAWIKTRPIQLRFIELMQTGEMDALFARHHVSGISIRDYLFGNGWLLKARADNDGPAQVFIHPDFQGEIGLIMPYEKDFCRSCNRLRVSALGKLHLCLFGEQGIELRDLLQDDHQENALIERIQTQLQNKAETHFLHDGNSGVTPHLASIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: Y352_HAEIN
Sequence: MQLIKNNEYEYADIILSSFVNLGDSELKKIKNVQKLLTQVDIGHYYLNKLPAFDAYLQYNELYENKRITSGVYMCAVATVMGYKDLYLTGIDFYQEKGNPYAFHHQKENIIKLLPSFSQNKSQSDIHSMEYDLNALYFLQKHYGVNIYCISPESPLCNYFPLSPLNNPITFILEEKKNYTQDILIPPKFVYKKIGIYSKPRIYQNLIFRLIWDILRLPNDIKHALKSRKWD
What are the official names of this protein?
Uncharacterized protein HI_0352, ORF1.
Protein: SQS10_PANGI
Sequence: MGSLGAILKHPEDFYPLLKLKIAARHAEKQIPSEPHWAFCYSMLHKVSRSFGLVIQQLGPQLRDAVCIFYLVLRALDTVEDDTSISTEVKVPILMAFHRHIYDNDWHFSCGTKEYKVLMDEFHHVSNAFLDLGSGYKEAIEDITMRMGAGMAKFICKEVETIDDYDEYCHYVAGLVGLGLSKLFHASGAEDLATDSLSNSMGLFLQKTNIIRDYLEDINEIPKSRMFWPRQIWSKYVDKLEDLKYEENSAKAVQCLNDMVTDALVHAEDCLKYMSDLRGPAIFRFCAIPQIMAIGTLALCFNNTQVFRGVVKMRRGLTAKVIDQTKTMSDVYGAFFDFSCLLKSKVDNNDPNATKTLSRLEAIQKICKNSGALTTKRKSYIIENESGYNSTLIVILFIILAILYAYLSSNLPNSL
What is the function of this protein?
Component of the triterpene saponins (e. g.  ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:29378087).  Catalyzes the biosynthesis of squalene (By similarity).
What are the official names of this protein?
Squalene synthase 10, PgSS10, SQS 10, FPP:FPP farnesyltransferase SS10, Farnesyl-diphosphate farnesyltransferase SS10.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MIF_SHEEP
Sequence: MPMFVVNTNVPRASVPDGLLSELTQQLAQATGKPAQYIAVHVVPDQLMTFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLTERLRISPDRIYINFCDMNAANVGWNGSTFA
What is the function of this protein?
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens.  The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense.  Counteracts the anti-inflammatory activity of glucocorticoids.  Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known.  It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
What are the official names of this protein?
Macrophage migration inhibitory factor, MIF, L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase.
What is the protein family that this protein belongs to?
Belongs to the MIF family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non- classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
Protein: YIC4_YEAST
Sequence: MSNFLLVIPEDVIKGCSKADKLVVTGEFDNWRHSDYVLQYDGSTQNYRVQIPRRKGQRSTMFKVVINDKKWVTLNYFDTVTDKSGYTNNILHFKDNEASQLMDIPLSPHTRSNTAKGKPEDDSLNDYVNLSSHSDLSSTEEIVCWNSDMEDENMDATIQCDFHQAFNSRKESLNGLMCIAKKVKTYWNK
What are the official names of this protein?
Uncharacterized protein YIL024C.
Protein: CH60_CAMLR
Sequence: MAKEIFFSDEARNKLYEGVKKLNDAVKVTMGPRGRNVLIQKSFGAPTITKDGVSVAKEVELKDSLENMGASLVREVASKTADQAGDGTTTATVLAHAIFKEGLRNITAGANPIEVKRGMDKACEAIVAELKKLSREVKDKKEIAQVATISANSDEKIGNLIADAMEKVGKDGVITVEEAKSINDELNVVEGMQFDRGYLSPYFITNTEKMTAELQNPFILLFDKKIANLKDLLPILEQIQKTGKPLLIIAEDIEGEALATLVVNKLRGVLNISAVKAPGFGDRRKAMLEDIAILTGGEVISEELGRTLESASIQDLGQASSVIIDKDNTTIVNGAGEKANINARINQIKAQIAETSSDYDREKLQERLAKLSGGVAVIKVGAATETEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIKAKSKISLNLQGDEAIGAAIVERALRAPLRQIAENAGFDAGVVVNTVENSKEENTGFDAAKGEYVNMLESGIIDPVKVERVALLNAVSVASMLLTTEATISEIKEDKPAMPDMSGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUUR_DROER
Sequence: MYHFVSEQTPELRLSAEALVTSRVTQYLKSFQLDAVRFVYDRLAKREFCILNDESGLGKVATVAALLSALPPAKKTLVVLQNDEQLLTGWRFHLDTLTDLQVYIIQGVHDTTDSPHSVYLAKWSQLRSIGDLSRLKFDYIMVDNRGHSLNNSFCTSMLLKQFEGRVNVLISSVDITSDVKLLYNVLRLGDRLEHQYKSFSRFDRKFHLPDPKEVFSKRIDLEEYYKQRGFLSEYIKDFRLRRFRHQFDKTLPLVAPEQYKHNLNLWLASKNSQSTLSGSEVCSTVASIENNPPQQNETVLVEESDRISEHSVDDVVAMSPLIFESSESDDEPITVDPVANENPVLVVSSDDCEIVTPPNTPPNRTPLVNKSPRTKSKKKCSKKPSPCKEADLTDSEKDDEGLTMPPRKSTRAATVHFTPKTRRLNVRLLRVSLDALSTPTPSGATTAIITPKTEPSARRKNRTKQPMDVGRPATRGMQRLTRSAESKINSKYLKHHVLDDAKRNFPRRIKAEGNQTPKTSKRIVKQESKAKAKPEQKKKIKTVDKPAQETPKRKPGRPRKCKTLTETLGKSKTKPNSKPLPPTPQVLSGSSLSSEYMQCAQRIPDDLDAIESPAFRVPFTPQQTPMLLTLPSTHNLLNDSEVVAIPLFKDQVETVVINSSHDESSPQDPSQSRRTKALKRKRKPDAPVNSSFGGGLGLPQAKRSATNKSPDLFSISSDLSQIPLAQPRPSSPFEGFKIFGSEVKQFQQQHAKVTIPAPKKKRDRSCLDILEQMFEPRLQQSSKTSPKVLPTLPLIQKDDATTTFTQRRGTLLEDDFFEITNNGQFGSRMRLNASGEVSPVQQDQQSVRPTQANKITNYLIGSVITQERTQPSNGNRNSIVASLRKSPKSPKHGARTTQATKLTRWFGSVFGGGASQTSSVESVSAPSTPVNPSTSAAACQTRTARSGGATGPTKRKRLELFK
What is the function of this protein?
Required for underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes.  Controls chromatin organization in polytene chromosomes (By similarity).
What are the official names of this protein?
Protein suppressor of underreplication.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Binds to polytene chromosomes from salivary glands. Localized at late-replicating intercalary heterochromatin and pericentric heterochromatin. Colocalizes with many Polycomb Group proteins binding sites on polytene chromosomes (By similarity).
Protein: GLTB_MAIZE
Sequence: MATLPRAAPPTPAALLPLPRAAPPLLLAGRAAAARRSRLRARGPSAAARRSWVVASAASSSSRAVVGGVARREAPPAPQKPTQQAADLNHILSERGACGVGFVANLKNMSSFDIVRDALMALGCMEHRGGCGADSDSGDGAGLMSAVPWDLFDDWASKQGLALFDRRNTGVGMVFLPQDEKSMEEAKAATEKVFVDEGLEVLGWRPVPFNVSVVGRNAKETMPNIQQIFVKVAKEDNADDIERELYISRKLIERAAKSFSWADELYFCSLSSRTIVYKGMLRSEVLGQFYLDLQNELYKSPFAIYHRRFSTNTSPRWPLAQPMRLLGHNGEINTIQGNLNWMRSRETTLKSPVWRGREHEICPFGDPKASDSANLDSTAELLLRSGRSPAEALMILVPEAYKNHPTLSIKYPEVTDFYDYYKGQMEAWDGPALLLFSDGRTVGATLDRNGLRPARYWRTSDDFVYVASEVGVIPMDESKVVMKGRLGPGMMITVDLQTGQVLENTEVKKTVASASPYGTWLQECTRLIKPVNFLSSTIMDNETVLRHQQAFGYSSEDVQMVIESMASQGKEPTFCMGDDIPLAVLSQRPHLLYDYFKQRFAQVTNPAIDPLREGLVMSLEVNIGKRGNILEVGPENADQVALSSPVLNEGELETLLNDSKLKPKVLSTYFDIRKGLDGSLDKTIQALCEEADAAVRSGSQLLVLSDRSEAPEPTRPAIPILLAVGAIHQHLIQNGLRMSASIVADTAQCFSTHHFACLIGYGASAVCPYLALETCRQWRLSNKTLNLMRNGKMPTVTIEQAQRNFIKAVKSGLLKILSKMGISLLSSYCGAQIFEIYGLGQEVVDLAFCGSVSKIGGLTLDELGRETLSFWVKAFSEDTAKRLENFGFIQSRPGGEYHANNPEMSKLLHKAIREKRDNAYTVYQQHLASRPVNVLRDLLELKSDRAPIPIGKVESATSIVERFCTGGMSLGAISRETHEAIAIAMNRIGGKSNSGEGGEDPIRWNPLTDVVDGYSPTLPHLKGLQNGDTATSAIKQVASGRFGVTPTFLVNADQIEIKIAQGAKPGEGGQLPGKKVSAYIARLRNSKPGVPLISPPPHHDIYSIEDLAQLIYDLHQINPKAKVSVKLVSEAGIGTVASGVSKANADIIQISGHDGGTGASPISSIKHAGGPWELGLTETNQTLIQNGLRERVVLRVDGGFRSGQDVLIAAAMGADEYGFGSVAMIATGCVMARICHTNNCPVGVASQREELRARFPGVPGDLVNYFLFVAEEVRAALAQLGYEKLDDIIGRTDLLKPKHISLVKTQHIDLGYLLSNAGLPEWSSSQIRSQDVHTNGPVLDETILADPEIADAIENEKEVSKAFQIYNVDRAVCGRVAGVIAKKYGDTGFAGQLNITFNGSAGQSFGCFLTPGMNIRLVGEANDYVGKGMAGGELVVVPVDKTGFVPEDATIVGNTCLYGATGGQVFVRGKAGERFAVRNSLCQAVVEGTGDHCCEYMTGGCVVVLGKAGRNVAAGMTGGLAYILDEDDTLVPKVNKEIVKMQRVNAPAGQMQLKGLIEAYVEKTGSEKGIAILREWEAYLPLFWQLVPPSEEDSPEACAEFERVLAKQATTQLSAK
What are the official names of this protein?
Ferredoxin-dependent glutamate synthase, chloroplastic, Fd-GOGAT.
What is the protein family that this protein belongs to?
Belongs to the glutamate synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: REX_LACLM
Sequence: MTDHKPSKSLPKATAKRLPQYYRLFKSLVEENVTRTNSQLISEKIGVDAATIRRDFSLFGELGRRGYGYETKVLRDFFGELLGQDQETHIALIGVGNLGRALLHYQFQDRNKMRITQAYDISGNPLVGTQTDDGIPIYNISDLEKNVKKSDIKTAILSVRKENAQEVVDTLVKAGIKGFLNFAPIRLKVPSDVVVQSIDLTKELQTLLFFMGAQEE
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBID_VIBVY
Sequence: MSFKDLRDFLNHLEKKGQLKRITHPVDPAYEMTEISDRTLRAGGPALLFENPIGYDIPVLTNLFGTAERVAMGMGREQVKELREVGQWLAYLKEPEPPKGFKDALDKLPVFKQVLNMPVKRLRKAACQEVVWQGEEVDLDKIPVMSCWQDDVAPLLTWGLTITRGPNKKRQNLGIYRQQKIAKNKIIMRWLAHRGGALDLRDWMEKYPGKPFPVSVAFGADPATILGAVTPVPDTLSEYAFAGLLRGSKTEVVKSASNDLEIPVSAEIVLEGYIDPNEYADEGPYGDHTGYYNEKEKHHVFTITHITMRKEPIYHSTYTGRPPDEPAVLGVALNEVFVPILQKQFPEIEDFYLPPEGCSYRMAVVTMKKQYPGHAKRVMMGVWSFLRQFMYTKYVVVCDESVNARDWDDVVKAMTENMNPILDSLFIESTPIDSLDFASPVAGLGSKMGLDATIKWEAELALQGATTSTEFASQIGFDVNALKAVHPLISDIYVPGVASGQFMVVKINKTHAGQCKEVVESLWQVESVKQRNKFIVVCDDDVKADDWHDIIWAITTRMDPARDTLKIDGSKSCSAKLVFDATNKYSEEITREWGKPIKKDPKLVAKVDALWQEFGIL
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CLPB_ECO57
Sequence: MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVSPLLTSAGINAGQLRTDINQALNRLPQVEGTGGDVQPSQDLVRVLNLCDKLAQKRGDNFISSELFVLAALESRGTLADILKAAGATTANITQAIEQMRGGESVNDQGAEDQRQALKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLALDMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSKPEELDRLDRRIIQLKLEQQALMKESDEASKKRLDMLNEELSDKERQYSELEEEWKAEKASLSGTQTIKAELEQAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQLEGKTMRLLRNKVTDAEIAEVLARWTGIPVSRMMESEREKLLRMEQELHHRVIGQNEAVDAVSNAIRRSRAGLADPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDEAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNLGSDLIQERFGELDYAHMKELVLGVVSHNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLKRLYKRLEERGYEIHISDEALKLLSENGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKVIRLEVNEDRIVAVQ
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_BACLD
Sequence: MTNVKTSSLGFPRIGLNREWKKSLEAYWKGNTDRETFLKEMDEQFLAALQTQLDQQIDIIPVSDFTMYDHVLDTAVMFNWIPDRFKDINDPLDTYFAMARGTKDAVSSEMTKWFNTNYHYIVPEYEKGAQYRVTRNKPLQDYQRAKAALGTETKPVILGLYTFVALAKGYEQQDIKDIYNQMTPLYIQVLKELEQEGVKWVQIDEPALVTASPEEAAAVKEIYQTITEEVSELNILLQTYFDSVDAYEELISFPVAGIGLDFVHDKGKNFEHLKAHGFPKDKVLAAGILDGRNIWKANLEERLDLTLELIQRAGVDEVWIQPSNSLLHVPVAKHPGEHLADDLLNGLSFAKEKLLELTLLKNGLVSGKAAIQAEIDEAHGHLQDLKQYGAATNSAFAEERGKLTEEDFKRPTAFEERLRIQNDSLGLPLLPTTTIGSFPQTADVRSARQKWRKKEWSDEQYEAFIQEETKKWIDIQEDLGLDVLVHGEFERTDMVEYFGEKLGGFAFTKYAWVQSYGSRCVRPPVIYGDVEFKEPMTVKETVYAQSLTSKKVKGMLTGPVTILNWSFARYDLPRKEIAFQIACALRKEVEALEKAGIQIIQVDEPALREGLPLKERDWDEYLKWAAEAFRLSTSSVEDTTQIHTHMCYSNFEDIVDAIEDLDADVITIEHSRSHGGFLDYLEQHPYLKGLGLGVYDIHSPRVPSSDEMLTIIEDALKVCPADRFWVNPDCGLKTRQPEETIAALKNMVEAAKQARGKLAQTV
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: SDC2_HUMAN
Sequence: MRRAWILLTLGLVACVSAESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGADEDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSERKMDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA
What is the function of this protein?
Cell surface proteoglycan which regulates dendritic arbor morphogenesis.
What are the official names of this protein?
Syndecan-2, SYND2, Fibroglycan, Heparan sulfate proteoglycan core protein, HSPG.
What is the protein family that this protein belongs to?
Belongs to the syndecan proteoglycan family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SAT_STACT
Sequence: MATATQIINYTSTPHGGELINRQLEGAEREALIKEAEAFPKLTLNAWSLSDLELIAIGGFSPLTGFMGEADYTNVVENLHLADGTLWSIPITLPVTEEQADAYELGSKIALYGEDDKLYGVLDLQEKFTYDKEKEAENVYGTTEEAHPGVKKVYEKGNVYLAGPIQLVNRPDHSEFEEFELDPIEVRQMFHDLGWKTVVGFQTRNPVHRAHEYIQKSALETVDGLLLNPLVGETKADDIPADVRMESYQVILKNYFPENRARLAIYPAAMRYAGPREAILHAIVRLNYGCTHFIVGRDHAGVGDYYGTYEAQELISQYEDELGINIMKFEHAFYCTKCENMATAKTCPHDKKYHVHLSGTKVREKLRNGEPLPKEFSRPEVAEVLIRGLRRHREQNGEG
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: JIP5_SCLS1
Sequence: MFENLCTLPLSSELFTQTLHPTEPILAVGLSGGHVHAFRLPVEEQELDEHGDADGNGSVLSTGTSTIETEWRTRRHKGSCRTLGFSGDGGVLYSAGTDSLLKAAASATGQVISKIRIPNSNTDALDPPTLLHALSPQTLLLATDSCALHLYDLRDVSSFKSGKPAQTHYPHDDYISSLSPLPPTEMSTSGFSKQWVTTGGTTLAVTDLRRGVLVKSEDQEEELLSSVFVGGLPARGKYGREKVCVGNGNGVVTLWEKGVWDDQSERIIVDGGGKAGGESLDSMVAVPEELEGSYGGKCVVVGCGDGSVRVVRVGGMKGVVEDLKHDDIEAVVAVGFDIGGRLISGGGETVKVWQEKVEDEEEEEEEEQEDIEDHDDDVIGGSGKRTLEKDSDDSDVKADSSDEEDGGRKKRKKKKRGKKGQVGNGILGFKGME
What are the official names of this protein?
WD repeat-containing protein jip5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NADA_VIBC1
Sequence: MSHILDKIETVYPFPPKPIPLSQEEKADYIERIKKLLKEKDAVLIAHYYTDPEIQALAEETGGFVGDSLEMAKFGNRHPASTLIIGGVRFMGESAKILTPEKRILMPTLEAECSLDLGCPADKFSEFCDAHPDHTVVVYANTSAAVKARADWVVTSSIALDIVEHLDAEDKPIIWGPDRHLGSYIAKKTGADMLLWHAECVVHDEFSADALRKMKNVYPDAAILVHPESPASVVELADAVGSTSQLIKAAKELPQQQMIVATDKGIFFKMQQLVPEKELIEAPTAGAGATCRSCAHCPWMAMNGLKAIEKALSEGGAEHEIFVDEALRVKSLIPLNRMLDFAEQLNMQVKGNA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_METST
Sequence: MDLQVEKINKISGVIKAPASKSYSHRAFIAAALAEGQSILRDPLYSADTIATLEACEQLGALFQRYPDKCIVQGTAGYIRTPENIIDVKNSGTSVRILSSVAAIAPRANYTIFTGDESLRKRPMQDLIDALENLGVQISSSQSNGTPPIIVKGGFEGGQTDIKGDVSSQFISSIIMAAPYSKKPVTLNVKGTFVSKPYVNMTLSVISKFGIDFEYDTTNIPEYSSYYIEPQKYEATDYTIEGDYSSASYILAAAAMLPSNLTVKNLYKDSMQGDKIIIDIIKKMGAEVTVDDDQIHIESDGNLKAFDINLEDAPDLLPTISILMAQAEGVSKITGVEHARFKETDRVHNCAVELENVGVDVEELQDGLIIKGNPTGGYVDSHMDHRMVMAFYVLGLKIGNIIIKDASCYDISFPNFLEVMHTISEE
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_STRZP
Sequence: MKIIIQRVKKAQVSIEGQIQGKINQGFLLLVGVGPEDQEEDLDYAVRKLVNMRIFSDAEGKMNLSVKDIEGEILSISQFTLFADTKKGNRPAFTGAAKPDMASDFYDAFNQKLAQEVPVQTGIFGADMQVELVNNGPVTIILDTKKR
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_VIBCH
Sequence: MSVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVKVEAGAEAFTLKTAGRFVDKLPANPQENIVYDCWQVFARELEKKSVVLKPLTMTLEKNMPIGSGLGSSACSIVAALDALNQFHASPLDETELLALMGEMEGKISGSIHYDNVAPCYLGGVQLMLEELGIISQSVPSFDDWYWVMAYPGIKVSTAEARAILPAQYRRQDIVAHGRYLAGFIHACHTQQPELAAKMIKDVIAEPYREKLLPGFAKARNYAASAGALATGISGSGPTLFSVCKEQAVAERVARWLEQNYVQNEEGFVHICRLDKQGSKVTGSEL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_CORK4
Sequence: MIDSLHGEVLHVGLNYVVIECSGVGYRATASPSLLGTLRKGEDARILVTMNVRDDGIDLYAFESDEARQMFAMLRKVSGVGPTSAMAICSIFKPDEFARIITDEDDAELRNVKGIGKRTAERIIVDLKSKVAVFDSGDSASEPQSGVGGNSEAEVDSGVVGTVTQALVELGFPEKQAEKTATSAAAEGGSVSEILKRALRSMSSERN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.