PharMolix/UniProtQA huggingface dataset:
Protein: NAA20_HUMAN
Sequence: MTTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE
What is the function of this protein?
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638).  Proteins with cell cycle functions are overrepresented in the pool of NatB substrates.  Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
What are the official names of this protein?
N-alpha-acetyltransferase 20, Methionine N-acetyltransferase, N-acetyltransferase 5, N-terminal acetyltransferase B complex catalytic subunit NAA20, N-terminal acetyltransferase B complex catalytic subunit NAT5, NatB complex subunit NAT5, NatB catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ARD1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MURD_CLOBH
Sequence: MKSNFSKFKDFIKYKKVAVVGIGVSNRPLIKFLVKLGAKVTAFDKKHREKLGSISLELEEIGVDLVLGENYLDKLDGYDVIFKTPSMRIDRPEFVKAKESGAYITSEMEEFIKYCPAKVFGITGSDGKTTTTTLVYEMLKKEGYRTWVGGNIGTPLFANIEEMKEDHMVVLELSSFQLMTMDVSPEISLITNLSPNHLDVHKDFEEYVWAKKNIFKYQSSNNLLVLNKDDDLTNGMENEALGDVLKFSLVEKVYNGACLSNNKLTIQGKEVCDSKDIKLKGRHNIANLLAAFCMVNKYVSIDSMKYVATNFSGVEHRCEFIREVNGIKYYNDSIASSPSRTLAGLNSFEKPVILIAGGYDKKIPFEPLAEGGYDKIKILILMGDTKNKIKSAFEKVISYKKCEMEIVIVNSMEEAVKVADNMAEKGDIITLSPACASFDMYPNFEIRGNEFKNIVNSL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHF2A_ARATH
Sequence: MEGAGETTTSEGHLTSAAAFVEGGIQDACDDACSICLESFCESDPSTLTSCKHEYHLQCILEWCQRSSQCPMCWQSISLKDPTSQELLEAVEQERNFRFNPTRNATIFRHPTLGDFELQHLPVGVDNAEIEERIIQHLAAAAAMGRARHGVRREGHRSRSSSQGHQQFMVFSSQPNASSPPPHPPMPSSPSQRDESDTVSNLPHNALGEGSHQSNTQPPTSSHPRQVSPSASDSNSRPLNQSSPSEQDRAGPSELQSFSESLKSRLNAVSTRYKESISKNTRNWKDRLFSRNTSMADLGSEVKREVSAGIATVSRMMERLETRENSRPSTASVSDVSENHTPETNNEHNRAAAGDEHSVNERGVKETCATGSGSS
What is the function of this protein?
E3 ubiquitin-protein ligase involved in the positive regulation of the gametogenesis progression.  Required for the degradation of KRP6, a cyclin-dependent kinase inhibitor which accumulates during meiosis and blocks the progression of subsequent mitoses during gametophytes development.  Functions in association with RHF1A.
What are the official names of this protein?
E3 ubiquitin-protein ligase RHF2A, RING-H2 finger F2a, RING-H2 zinc finger protein RHF2a, RING-type E3 ubiquitin transferase RHF2A.
Protein: SK1_POLAY
Sequence: EQFDDYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-1, PolAe-SK-1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ANEF_ASPA1
Sequence: MIAGLVLVVLLTKYLQRVFLHPLSKFPGPSIAAVSHLWEFWHDWVKNGTFLEGVADLHRSYKSPVVRIAPNHLHVNDVEVYHQVFKVNTNFYKAPYFYEAFGFATSIATITNPHRHKPLRTTVAPMFTGTAVDGMSDEMYDMVRKATDLLAARSTGTGNKFNVMQFLRCITTDVSCNLIFGETLDLVSNGYHSDRFLGNLDTFVENVWIMVHAPWIAQFALMLPNSLTDKIVPGYAYFREQCISWIDKVRARRAKGITLMRNGRPTLFDVLMDDNPDKNYKVPSKSELIDQAFLFAIAGTDTTSMATTFAVFHILNNPAVRERLCEELRGASAIIRDQYNYREVRKLPYLSAVIKEALRMSSPFPGRLPRVVPPEGMKLDNKFVPGGTIISISSRCIMDDPKIYPEPEKFLPERWMGENAKSMDRNMIAFGKGSRSCLGTNLAYLKMYTMLSTMFCRWDLRLVSPTDHKLRYLDHALIEMKSQVVVEILADHWTT
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aculenes, a unique type of norsesquiterpenes that contain a nordaucane skeleton linked to an L-proline moiety and are of mixed biosynthetic origin (PubMed:31618514).  The pathway begins with the synthesis of dauca-4,7-diene by the terpene cyclase aneC using farnesyl pyrophosphate (FPP) as substrate (PubMed:31618514).  The cytochrome P450 monooxygenase aneF then performs the initial oxidation at C-12 of dauca-4,7-diene to yield asperaculane D (PubMed:31618514).  Asperaculane D is substrate of the cytochrome P450 monooxygenase aneD for C-10 hydroxylation to yield asperaculane E (PubMed:31618514).  The cytochrome P450 monooxygenase aneG then converts asperaculane E into aculene D via C-2 oxidation (PubMed:31618514).  The monomodular nonribosomal peptide synthtase aneB adenylates L-proline and the thiohydrolase aneE transfers this activated L-proline derivative to aculenes D and C to produce respectively aculenes B and A (PubMed:31618514).  The dioxygenase aneA converts aculene D into aculene C, and aculene B into aculene A by introducing the 5,6-alkene moiety (PubMed:31618514).  Asperculanes A, B, C and F, as well as 14-prolyl asperculane C, might be shunt products of the pathway (PubMed:31618514).
What are the official names of this protein?
Cytochrome P450 monooxygenase aneF, Aculenes biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DAPB_PROMM
Sequence: MTSVPPELIPVVVVGALGRMGAEVIKAVHLASDCELVGAVDTTPGKEGVEIGEELGIGVLDVALTSDIEACLCSVSQSFHRTGPGQGAVLVDFTHPSVVYEHTRAAFAYGVHPVIGTTGLSHQQLVDLSEFAAKASMGGAVIPNFSVGMVLLQQAAAAAARFYDNAELTELHHNRKADAPSGTCIKTAEMMEELGKSFNSPEVDEHESLTGSRGGLRASGLRLHSLRLPGLVAHQEVMFGAPGESYTLRHDTIDRSAYMPGVLLTVRKVRQLQGLVYGLERLI
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMLC_MYCTO
Sequence: MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLDVRQVNCSVSSAGVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVDIREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAEYNPQREHTICATDPTLAVDWPLVDGAAPSLSDRDAAAPSFEDVRASGLLPRWEQTQRFIGEMRGT
What is the function of this protein?
Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.  Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.
What are the official names of this protein?
dTDP-4-dehydrorhamnose 3,5-epimerase, Thymidine diphospho-4-keto-rhamnose 3,5-epimerase, dTDP-4-keto-6-deoxyglucose 3,5-epimerase, dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase, dTDP-L-rhamnose synthase.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
Protein: ICE2_HUMAN
Sequence: MSSKMVISEPGLNWDISPKNGLKTFFSRENYKDHSMAPSLKELRVLSNRRIGENLNASASSVENEPAVSSATQAKEKVKTTIGMVLLPKPRVPYPRFSRFSQREQRSYVDLLVKYAKIPANSKAVGINKNDYLQYLDMKKHVNEEVTEFLKFLQNSAKKCAQDYNMLSDDARLFTEKILRACIEQVKKYSEFYTLHEVTSLMGFFPFRVEMGLKLEKTLLALGSVKYVKTVFPSMPIKLQLSKDDIATIETSEQTAEAMHYDISKDPNAEKLVSRYHPQIALTSQSLFTLLNNHGPTYKEQWEIPVCIQVIPVAGSKPVKVIYINSPLPQKKMTMRERNQIFHEVPLKFMMSKNTSVPVSAVFMDKPEEFISEMDMSCEVNECRKIESLENLYLDFDDDVTELETFGVTTTKVSKSPSPASTSTVPNMTDAPTAPKAGTTTVAPSAPDISANSRSLSQILMEQLQKEKQLVTGMDGGPEECKNKDDQGFESCEKVSNSDKPLIQDSDLKTSDALQLENSQEIETSNKNDMTIDILHADGERPNVLENLDNSKEKTVGSEAAKTEDTVLCSSDTDEECLIIDTECKNNSDGKTAVVGSNLSSRPASPNSSSGQASVGNQTNTACSPEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPISRKVPELPLMNLENSKQPSVSEQLSGPSDSSSWPKSGWPSAFQKPKGRLPYELQDYVEDTSEYLAPQEGNFVYKLFSLQDLLLLVRCSVQRIETRPRSKKRKKIRRQFPVYVLPKVEYQACYGVEALTESELCRLWTESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAPHKRKIT
What is the function of this protein?
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
What are the official names of this protein?
Little elongation complex subunit 2, Interactor of little elongator complex ELL subunit 2, NMDA receptor-regulated protein 2.
What is the protein family that this protein belongs to?
Belongs to the ICE2 family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Protein: AMIF_AGRVS
Sequence: MNGLGGLNKSEHGVGIGLVQLQLPVTVTPQDLARQTQVIVDLVAKARRNQPGMDLVVFPEYALHGLSMDINPDIMCRMDGPEVAAFKAACKQNRIWGCFSIMEYNPGGMPYNSGIIIDDTGALKLYYRKMHPWVPVEPWEPGDLGIPVIDGPKGAKLALIICHDGMFPEMARECAYKGAEIMIRTAGYTAPIRESWRFTNQSNAFCNLMVTANVCMCGSDGTFDSMGEGMICNFDGSIIAHGTSGRVNEIITAEVRPDLVREARLGWGVENNIYQLGHRGYVAVAGGAQDAPYTYMHDLAAGRYRLPWEVEVKITDGTACGFEKPTRLYGKPAKSAAE
What is the function of this protein?
Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide.
What are the official names of this protein?
Formamidase, Formamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: RBM5B_XENLA
Sequence: MGSDKRVSRSERSGRYGSAFDRDDRDDRDSRSRRRDSEYKRYRDERNDQYDDYRDYESPERERMRDRERRNSDRSEDGYHSDGDYMDHDYRQDYYMDEKESKTIMLRGLPININENDIRELVESFEGPQPADVRLMKRKTGLSRGFAFVEFYHLQDATRWMEANQKKLVIQGKTIAMHYSNPRPKFEDWLCNKCGLYNFRRRLKCFRCGAAKAESDMEAPSGSSETPQSADYYSDSGYVSSAIILRNIGPHTVVDSILSALAPYVSLVVSNIRLIKDKQTQQNRGFAFVQLPSALEASQLLQILQTLHPPLKIDGKTIGVDFAKSARKDLVLPDGHRVSAFSVASTAIAAAQWSATQPAQQSGEAGDYAYLQQGQEGNSNFGQCSQDYQPFYQTQTAAVDQDTAPQSEGSPVPATTSAVVCQSPQMYQQPGSPTQSGTSTAASTTPASTTSTEEATTPTAIVPGVKYSVPDTSTYQYDESSGYYYDPQTGLYYDPNSQYYYNSLTQQYLYWDGEKQTYLPAADGTGQSGAQPNGANPGTSKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPLSSRDEERKESAAADAGFALFEKKQGALFERQFLPDMMMMMVNTEEEKPPNAKYRDRAAERREKYGIPEPPEPKRKRFDPTVVNYEQPTKDGIDNSNIGNKMLQAMGWKEGSGLGRKSQGITAPIQAQVRMRGAGLGAKGSSYGVNTSDSYKDAVKKAMFARFSEME
What is the function of this protein?
Component of the spliceosome A complex.  Regulates alternative splicing of a number of mRNAs.  May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron (By similarity).
What are the official names of this protein?
RNA-binding protein 5-B, RNA-binding motif protein 5-B.
What is the protein family that this protein belongs to?
Belongs to the RBM5/RBM10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CATA_STAS1
Sequence: MSNNKKLTSLFGAPVSDRENSMTAGPRGPLLMQDWYFLEQMAHFDREVIPERRMHAKGSGAFGTFTVTNDITQYTSASIFSEVGKQTEMFARFSTVAGERGAADAERDIRGFALKFYTDEGNWDLVGNNTPVFFFRDPKLFASLNHAIKRDPRTNMRSAQNNWDFWTSLPEALHQVTILMTDRGIPKGFRNMHGFGSHTYSMYNDKGERVWVKFHHRTQQGIENLQPDEAARTIAEDRESSQRDLFEAIENKDYPKWKTYIQVMTEEQARNHKDNPFDLTKVWYKGDYPLIEVGEWELNRNPDNYFQDVEQAAFAPTNIVPGIDFSPDRMLQGRLFSYGDAQRYRLGVNHWQIPVNQPKGVGIENICPFSRDGQMRILDNNQGGSTHYYPNSEGAFEDQPEFKKPGLKVEGEAYEYDFREDDDNYFEQPGRLFRLQSKEQQERIFENTANEMQGTTLEVQHRHIRHCYKADSEYGKGVAKALGIDINDVDLEVKD
What is the function of this protein?
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
What are the official names of this protein?
Catalase.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
Protein: THIM_PECAS
Sequence: MNTQPADFSAAQAATSLTQFRSAAPLVHCLTNDVVQSFTANVLLALNASPAMVVDPEEAAQFSAVADALLINVGTLERTRAEAMRAAVNSAHQAGTPWVLDPVAVGGLTFRTEFCRELLTWKPAAIRGNASEIMALAGLAAQGRGVDSADDSLAALPAARELARQVGTIVVVTGAVDYVTDGERDIAVTGGDSMMTRVVGTGCALSAVVAGFCSLEGDRLSHVTAACYVMALAGQQATSVSQGTGSFIPHFLDRLYTLRAEDLA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: YDJZ_ECOLI
Sequence: MMMMQSRKIWYYRITLIILLFAMLLAWALLPGVHEFINRSVAAFAAVDQQGIERFIQSYGALAAVVSFLLMILQAIAAPLPAFLITFANASLFGAFWGGLLSWTSSMAGAALCFFIARVMGREVVEKLTGKTVLDSMDGFFTRYGKHTILVCRLLPFVPFDPISYAAGLTSIRFRSFFIATGLGQLPATIVYSWAGSMLTGGTFWFVTGLFILFALTVVIFMAKKIWLERQKRNA
What are the official names of this protein?
TVP38/TMEM64 family inner membrane protein YdjZ.
What is the protein family that this protein belongs to?
Belongs to the TVP38/TMEM64 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DGKA_MOUSE
Sequence: MAKEKGLISPEDFAQLQKYIEYSTKRVSDVLKVFDDGEMNRFCQGDAIGYLGFEQFMKMYLEMEEVPHHLCWALFWSFHTSQVAAEKTKSKANVICLSDVYCYFTLLEGGRPEDKLEFTFKLYDMDRNGILDSTEVEKIILQMMRVAEYLDWDVSELRPILQEMMREMDQDGSGSVSLDEWVRAGATTVPLLVLLGMDVTMKDDGNHIWRPKRFTRLVYCNLCEQSISLGKQGLSCNFCKYIVHDHCAMKAQPCEVSTYAKSRKDIGVQSHLWVRGGCHSGRCDRCQKKIRTYHSLTGLHCVWCHLEIHDDCLQAVGPECDCGLLRDHILPPCSIYPSVLVSGQECKHKTTDDTSLCTPEAFRIEPVSNTHPLLVFINLKSGGKQGQSVLWKFQYILNPRQVFDLKDGPEPGLRFFKDVPQFRILVCGGDGTVGWVLETIDKANFATVPPVAVLPLGTGNDLARCLRWGRGYEGENLRKILKDIELSKVVYLDRWFLEVIPQQNGEKSDPVPSQIINNYFSIGVDASIAHRFHLMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESVTVEICGKLLDLSDLSLEGIAVLNIPSTHGGSNLWGDTKRPHGDTCEINQALGSAAKIITDPDILKTCVPDMSDKRLEVVGIEGAIEMGQIYTRLKSAGHRLAKCSEITFQTTKTLPMQIDGEPWMQAPCTIKITHKNQMPMLMGPPSNSYNFFGFWS
What is the function of this protein?
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids.  Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes.  Also plays an important role in the biosynthesis of complex lipids.  Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group.  Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol.
What are the official names of this protein?
Diacylglycerol kinase alpha, DAG kinase alpha, 80 kDa diacylglycerol kinase, Diglyceride kinase alpha, DGK-alpha.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RS16_FUSNN
Sequence: MLKLRLTRLGDKKRPSYRIVAMEALSKRDGGAIAYLGNYFPLEDSKVVLKEEEILNYLKNGAQPTRTVKSILVKAGLWAKFEESKKK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: DAPE_EHRCJ
Sequence: MAIDPIKLSQELISFPSITPTDNGAIDFLSNTLSQYGFTCHVLTFGDDQVQVRNLYAQLGNGSPNLCFAGHTDVVPTGDSEKWKFDPFSGKIEDNILYGRGVVDMKSAICAFVAAVSRIDFNQINGSISFLISGDEEGNYFKYGTPAVLKWLTDNNKKIDFCLVGEPTSQSSVGDTIKIGRRGSINFKIVCNGVQGHVAYPHLAENPVDNMISILYKISNTVLDNGNEYFQPSNCEITSVDVGNTATNVIPDKITANLNIRYNDMHTSESLFNIINNICAEITEKYELFTAVSGSSFITHPGKHSDMLSSAIKKVTGQDAILSTSGGTSDARFIKDFCPVIELGLSNETAHKINEHAPVDDIYKLTDIYEEFIRQFFNIS
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: ASIP_MOUSE
Sequence: MDVTRLLLATLVGFLCFFTVHSHLALEETLGDDRSLRSNSSMNSLDFSSVSIVALNKKSKKISRKEAEKRKRSSKKKASMKKVARPPPPSPCVATRDSCKPPAPACCDPCASCQCRFFGSACTCRVLNPNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).  Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti coat color protein, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: MAP1S_BOVIN
Sequence: MAATVAGSGAAEVPSSLLLVVGGECGCRGLLAYVLEELERGIRSWDIDPGVCSLDEQLKVFVSRHSATFSSIVKGQRSLHHRGDTLETLVLLNPSDKSLCDELRNLLLDTASHKLLVLAGPCLEETGELLLQTGGFSPRHFLQVLGDKEIRDLLASTPPPAAPPKLTITCPTFGDWARLAPEVPGLQGVLHLRLNPPVQLPASEGLREFLEYVAESLEPPSPFELLEPPASVGLLRLARPCCYIFPGGLGDAAFFAVNGFTVLVNGGSNPKSSFWKLVRHLDRVDAVLVTHAGADSLPGLNSLLRRKLAERDEAAAGGGSGDDRLRRLISPNLGVVFLNARAAASRLVRGEDEAELALSLLSQLGITPVPLNRGPLPAEPTVLFQKMGVGRLDMYVLHPPSAATTDHTLASVCALLVWHPAGPSEKVVRVLFPGCTPPARLLDGLVHLQHLGFLREPVVTPQDMAGPRRAESKESVASRDSLRREGRTTVPSRPTQERPGVARKDSPRTEAPRRAEKEARPSREVKKDPRPSAPRTQPREVRRAASAVVSGKNVGAQVAPKTRRAPNTPRPGVPPAENGPRSPPSFRSGEASPPTEACSSPAPQLVATPSQESSLDLGLSPAGEEGGSLEEKTLELLLAASTPEPCTPSPAGAQQGPTESSGPLSLSPLRGGEPGPDASPTVTTPSLPAEVGSPHSTEVDESLSVSFEQVLPPPAAAASEAGLSLPLCGPRVRRSASPHDVDLCLVSPCEFEHRKAVPMAPAPVSPGSSNDSSARSQERAGAPGGAEETPPTSVSESLPTLSDSDPLPAAPGTADSDEDTEGFGVPRRDPLPDPLKIPPPLPTPPSICMVDPEMLPPEQARLKGGGSRTRKPLTRPSSGTTPPKATPVTAAKIKGLASGDRASRPLSARSEPSDKGNRASLSRKPSVPKTTTRGPSGSAGSRSGGSAAPPGSPVYLDLAYLPSGGSARLVDEEFFRRVRALCYVISGQDQHKEEGMRAVLDALLAGKQQWDRQLQVTLIPTFDSVAMHEWYEETHTRHQALGITVLGSNSTVSMQDEAFPACKVEF
What is the function of this protein?
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD).  Plays a role in anchoring the microtubule organizing center to the centrosomes.  Binds to DNA.  Plays a role in apoptosis.  Involved in the formation of microtubule bundles (By similarity).
What are the official names of this protein?
Microtubule-associated protein 1S, MAP-1S.
What is the protein family that this protein belongs to?
Belongs to the MAP1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. Detected in filopodia- like protrusions and synapses (By similarity).
Protein: OBF1_MOUSE
Sequence: MLWQKSTAPEQAPAPPRPYQGVRVKEPVKELLRRKRGHTSVGAAGPPTAVVLPHQPLATYSTVGPSCLDMEVSASTVTEEGTLCAGWLSQPAPATLQPLAPWTPYTEYVSHEAVSCPYSTDMYVQPVCPSYTVVGPSSVLTYASPPLITNVTPRSTATPAVGPQLEGPEHQAPLTYFPWPQPLSTLPTSSLQYQPPAPTLSGPQFVQLPISIPEPVLQDMDDPRRAISSLTIDKLLLEEEESNTYELNHTLSVEGF
What is the function of this protein?
Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2.  It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2.  It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2.  It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:23045607).  Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (PubMed:23045607).
What are the official names of this protein?
POU domain class 2-associating factor 1, B-cell-specific coactivator OBF-1, BOB-1, BOB1, OCA-B, OCT-binding factor 1.
What is the protein family that this protein belongs to?
Belongs to the POU2AF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEUD_ALCBS
Sequence: MEKFVRHDGLVAPLDRANVDTDQIIPKQFLKSIKRTGFGPNLFDEWRYLDEGFPGQDNAARLVNNDFVLNQPDYQGASILLTRRNFGCGSSREHAPWALMDFGFKAIIAPSFADIFYNNCFKNGLLPIVLSEDNVEALFQVVSSKGGYRITIDLEGQQVIPESGEPLPFEIDEFRKHCLLNGLDEIGLTLNEADAIRAYERSRIEREPWVFADH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: FOLD_DECAR
Sequence: MTAQIIDGKALAEELRQGFKARVEALTAKGHKPGLVVILVGADPASEVYVRNKVNGCLAIGMHSEKITYDATIDQATVLNKIAELNADPNIHGILVQLPLPKHFDEEAVLEAISAEKDVDGFHAENVGALAQGNPRFIPCTPYGVMKMFEKGNVDLTGKEAVVIGRSNIVGKPMALLLINAGATVTVCNSRTKDLKFHTSRADILVAAVGKPKFVTGDMVKPGAVVIDVGINRLPDGKLCGDVDFASCLEVAGQITPVPGGVGPMTITMLLANTIEAAERKAGL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SEPF_TROWT
Sequence: MAGGLKKAMVYLGLAEDNQELHSAPSGMSHLRRVPHPKQQMSEIFTFHPKKYSEVSGIVERFRQNIPVIIDMSQLSDTDARRMIDFASGLSQGLVGKIERVVGKVFLLSPEHISISTESKKEE
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: SYL_LACH4
Sequence: MYNHKVVEKKWQDYWAKHDTFKTGTDPKKKNYYALDMFPFPSGKGLHVGHPEGYTATDIVSRMKRAQGYNVLHPMGWDAFGLPTEQYALKTGEDPAVVTKNNIANFKRQLNKLGFSYDWDREITTSDPNYYKWTQWVFEQMYKKGLAYEAEVPVNWSPDLGTVVANEEVIDGKTERGGYPVYRRNMRQWMLKMTAYADRLLEDLDDLDWPEPVKEMQRNWIGRSVGAQVTFKIKDSDKTFDIFTTRPDTLFGCSYTVLAPENKLVQEITTDGHRDEVNAYIKKIESKSDLERTDLNKDKTGVFTGAYAINPVNGKEVPIWISDYVLASYGTGAVMAVPAHDDRDYAFAKKFDLPINQVLEGGDLSKAAFTEDGPHINSEFLNGLNIKDAKKKMVDWLEEHNCGEKKVNYKLRDWDFSRQRYWGEPIPVIHWEDGTTSLVPEDQLPLRLPHATDIKPSGTPESPLANLTDWVNVVDEMGRKGKRETNTMPNWAGSSWYYLRYVDPHNDKELADYDLLKQWLPVDLYIGGAEHAVRHLLYARFWHKVLYDLGVVPTKEPFQRLYNQGLILKNHEKMSKSKGNVVNPDEVIDEYGADSLRMYEMFMGPLDASIDWDDNGPASTKKFLDRVWRLFVNDLDLKAIPQERIVDKNDGELDKVYAETVKKVTEDFDALHFNTAISQMMVFINAAQKAKTIPREYVEGFVKLLAPVAPHMMEEIWQVFGHDESITYAKWPTYDPAKLVESTVEIMVQVNGKLRGKFEAAKDADRDDVQKQAMALPHVQKFLEGKDVKKVIVVPNKIVNIVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.