PharMolix/UniProtQA huggingface dataset:
Protein: Y2426_SACD2
Sequence: MKLSLNETRVIGVLIEKEVTTPDQYPMSLNALTNACNQKTNREPVLNLSETEVQESLDALAKQGLVVESRVGNRIPKYKHRFCNSEFGELQFTKQELAIVCTLFLRGAQTPGELRTRTNRLCTFADVQETEKVLQGLIDHSRGSYVVKLEREPGKRESRYAHLFSGDAATTVAQIPATTNTSTPAQSNSPQNNAELLERVEMLELTVEELQNQINKLVEQLGG
What are the official names of this protein?
UPF0502 protein Sde_2426.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: AGUA_STRR6
Sequence: MMDSPKKLGYHMPAEYEPHHGTLMIWPIRPGSWPFQGKAAKRAFTQIIETIAEGERVYLLVEQAYLSEAQSYLGDKVVYLDIPTNDAWARDTGPTILVNDKGKKLAVDWAFNAWGGTYDGLYQDYEEDDQVASRFAEALERPVYDAKPFVLEGGAIHSDGQGTILVTESCLLSPGRNPNLTKEEIENTLLESLGAEKVIWLPYGIYQDETNEHVDNVVAFVGPAEVVLAWTDDENDPQYAMSKADLELLEQETDAKGCHFTIHKLPIPAVRQVVTEEDLPGYIYEEGEEERYAGERLAASYVNFYIANKAVLVPQFEDVNDQVALDILSKCFPDRKVVGIPARDILLGGGNIHCITQQIPE
What are the official names of this protein?
Putative agmatine deiminase, Agmatine iminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the agmatine deiminase family.
Protein: NUOH_BARHE
Sequence: MIYDFFMTWLFPLLIIVGKTLLLLVILLLLVAYLLYADRKIWAAVQLRRGPNVVGPWGLLQSFADLIKFVVKEPIIPAGANKGVFLLAPFVSATLALSTWAVIPVNEGWAVANINVGLLYILAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVLVTVILVSGSLDLTTIVQKQSHGMGTALGLPFNSFLDWNWLVLFPMFIIFFISALAETNRPPFDLVEAESELVAGHMVEYSSTPYMLFFLGEYVAIVLMCALTTILFLGGWLPPLDVWWLNWVPGIIWFVLKVCFVFFWFAMVKAFVPRYRYDQLMRLGWKVFLPLSLAMVVITAAFLKYTGFA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HYAL_ECHPL
Sequence: MYHIWIKFLAAWIFLKRFNGVHVMQAKAPMYRNEPFLVFWNAPTTQCRLRYKVDLDLKTFHIVSNANDSLSGSAVTIFYPNHLGVYPHIDDRGHFFHGIIPQNESLTKHLNKSKSDINRIIPLKAFHGLGVIDWENWRPQWDRNWGSKNVYRNRSIQFARDLHPELSEDKIRRLAKKEYEKAAKSFMRDTLLLAEEMRPDGYWGYYLYPDCQNYDYKTKGDQYTGKCPEIEMSRNDQLLWLWRDSTALFPNVYLEIILRSSDNALKFVHHRLKEAMRIASMAREDYALPVFAYARPFYAYTFEPLTQEDLVTTVGETAAMGAAGIVFWGSMQYASTVDSCQKVKKYMNGPLGRYIVNVTTAAKICSRVFCRKNGRCVRKHSDSNAFLHLFPESFRIMVYANATEKKVIVKGKLELENLIYLRENFMCQCYQGWKGLYCEEYSIKDIRKI
What is the function of this protein?
Snake venom endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments.  In venom, it is not toxic by itself, but increases the diffusion of other venom proteins by degrading the extracellular matrix.  In addition, it displays antiedematogenic activity (By similarity).
What are the official names of this protein?
Hyaluronidase, Hy, Hyaluronoglucosaminidase, Venom spreading factor.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 56 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAA_BUCBP
Sequence: MSPSIWEKCLKYLQNKLSPIEFSMWIRPLKAEFKKNILILYAPNEFSFNWIKDNYIENLKKLLKNFCNINTTPTLMLKICKPKIIQKKFFNELTLKKNILNSKLTYNVNTKLSNIIYSSEINTNYTFQNFTKGQSNQLAFKTIYKIAHNPGKNYFNPLFLYGKSGLGKTHLLHAVANTILKYKNTIKIIYINSENFIQNMITSLKNNTIEEFKKYYRSVNTLLIDDIQFFAYKKHSQEELFHTINALLNRNQQIIITSDQFPQKIHGIETRLKSRFECGLTIRIDPPDLNTRTKILIKKSHIYDINLSYKVAFFIAKNLKSNIRELEGALNKILANSDSKKKIITINFAYKTLQELFSLPKKSITIKNIQKVVSNYYHITIINLLSQCRLKSIVKPRQIAMAISKKLTNKSLSEIGREFNGRNHATVLYACKKIKKLQEKNNNIKKDFLTLLKILSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBI_LIRTU
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MDL1_PRUDU
Sequence: MEKSTMSVILFVLHLLVLHLQYSEVHSLANTSAHDFSYLKFVYNATDTSLEGSYDYIVIGGGTSGCPLAATLSEKYKVLLLERGTIATEYPNTLTADGFAYNLQQQDDGKTPVERFVSEDGIDNVRARILGGTTIINAGVYARANISFYSQTGIEWDLDLVNKTYEWVEDAIVVKPNNQSWQSVIGEGFLEAGILPDNGFSLDHEAGTRLTGSTFDNNGTRHAADELLNKGDPNNLLVAVQASVEKILFSSNTSNLSAIGVIYTDSDGNSHQAFVRGNGEVIVSAGTIGTPQLLLLSGVGPESYLSSLNITVVQPNPYVGQFLYNNPRNFINNFPPNPIEASVVTVLGIRSDYYQVSLSSLPFSTPPFSLFPTTSYPLPNSTFAHIVSQVPGPLSHGSVTLNSSSDVRIAPNIKFNYYSNSTDLANCVSGMKKLGDLLRTKALEPYKARDVLGIDGFNYLGVPLPENQTDDASFETFCLDNVASYWHYHGGSLVGKVLDDSFRVMGIKALRVVDASTFPYEPNSHPQGFYLMLGRYVGLQILQERSIRLEAIHNIQESM
What is the function of this protein?
Involved in cyanogenesis, the release of HCN from injured tissues.  Catalyzes the stereospecific addition of HCN to a variety of aldehydes in vitro.  It is a major seed constituent, and could have the additional role of a storage form for reduced nitrogen (By similarity).
What are the official names of this protein?
(R)-mandelonitrile lyase 1, Hydroxynitrile lyase 1, (R)-oxynitrilase 1.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: GCS21_PAEAT
Sequence: MGRVAVRTFGVEEELLIADPVDGMPLALASGILDVAGFSETDNSSDAGPSLKSEFKQEQIEVNSLPCRTAKELRAEIRAGRALADSAARAVGARVAALATPPVFHATPTAGNQRYAAMGTEFGLISREQLTCGFHVHVSIESPEEGVAVLDRMRHWLPVLLALSANSPFWMGADTGFASYRTQIWNRWPTAGPMDVFGSADGYRQVLSELLGTGVPLDEGMIYFDARLSRGHPTVEVRIADVCLYAEDALTIAILARALVETSASEWRKGEPPSGVMTPVIRMANWKASRFGVTNQLLHPLEQAPFAAADVAGALLRHIRRALTESGDLALARTGVANILRRGTGERLQRQAYGRRFRLSDVVSTAIASTHNYGERSDAGLLSR
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2-1, Gamma-glutamylcysteine synthetase 2-1, GCS 2-1, Gamma-GCS 2-1.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: HSP70_THEAN
Sequence: MTGPAIGIDLGTTYSCVAVYKDNNVEIIPNDQGNRTTPSYVAFTDTERLIGDAAKNQEARNPENTIFDAKRLIGRKFDDRTVQEDMKHWPFKVTNGPNGKPNIEVTFQGEKKTFHAEEISSMVLTKMKEIAESFLGKSVKDVVITVPAYFNDSQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKKGGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKATAGDTHLGGEDFDNLLVEHCVRDFMRLNNGKNISSNKRALRRLRTHCERAKRVLSSSTQATIELDSLYEGIDYNTTISRARFEELCNEKFRSTLVPVEKALESSGLDKRSIHEVVLVGGSTRIPKIQTLIKNFFNGKEPCRSINPDEAVAYGAAVQAAILSGNQSEKIQELLLLDVAPLSLGLETAGGVMTVLIKRNTTIPTKKNQIFTTNEDRQEGVLIQVFEGERAMTKDNNLLGKFHLTGIAPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKSEHVTITNDKGRLSQEEIDRMVEEAEKYKEEDEKRRRCVESRHKLENYCYSMKNTLSEDQVKQKLGADEVDSALSTITDALKWVEANQLAEHDEYEDKLKHVEGVCNPLVTKLYQSGAAPGGPDMSGGFPGGAAPPPQSSGPTVEEVD
What are the official names of this protein?
Heat shock 70 kDa protein, 70 kDa heat shock protein, HSP 70.1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ASTC_SHISS
Sequence: MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALIDDATCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYAYMHYGVTPDLLTTAKALGGGFPVGALLTTEECASVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNTINHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
What is the function of this protein?
Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate.  Can also act as an acetylornithine aminotransferase.
What are the official names of this protein?
Succinylornithine transaminase, SOAT, Succinylornithine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily.
Protein: NU3C_CHAVU
Sequence: MGTLQEYDYLWFFLVIASIVPILAFTISEILAPIRSGPEKLTSYESGIEPKGQAWIQFHIRYYMFALVFVVFDVETVFLYPWAISFHSLGISAFIEALLFILILMVGLVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TMA20_SCHPO
Sequence: MFKRFNSREDIKGTTPIKSSIQRGIKAKLVQAYPNLKQVIDELIPKKSQLTQIKCEDRLFLYTLNGEIILFQHFDGPIIPSLRLVHKCPDAFTQVRVDRGAIKFLLSGANIMIPGLVSKGGNLPDDIEKDQYVIVTAEGKEAPAAIGLTKMSAKEMKETNKGIGIENVHYLGDNLWKTILE
What is the function of this protein?
Involved in translation.
What are the official names of this protein?
Translation machinery-associated protein 20.
What is the protein family that this protein belongs to?
Belongs to the TMA20 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_ESCF3
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLDDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLEWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRIC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_WIGBR
Sequence: MPRRKMVNQRAILPDPKWNSEILSKFINILMVNGKKSISEKIIYTALNNLKKKLNKDHLTIFDLALEKVRPIVEVKSRRVGGSTYQVPIEVRSSRRNALAMRWIIEAARKRKDKSMSLRLAKEIEDALENKGTAVKKREEVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: GREA_BEII9
Sequence: MDKFPMTPEGYHALDEELKRRQQEERPRIIQAIAEARSHGDLSENAEYHAAKEAQSLNEGRIAELEDKLSRAEIIDVSKLSGNTVMFGATVTLVDEDTEEEKIYQIVGESEADVKAGRVSITSPTARALIGKKIGDSVEVNTPGGGKSYEILNVAFQ
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: H33_TETTS
Sequence: MARTKQTARKSTGVKAPRKQLATKAARKSAPVSGGVKKPHKFRPGTVALREIRKYQKTTDLLIRKLPFQRLVRDIAMEMKSDIRFQSQAILALQEAAEAYLVGLFEDTNLCAIHARRVTIMTKDLHLARRIRGERF
What is the function of this protein?
Macronuclear replacement variant which replaces conventional H3 in a subset of nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  Functions redundantly to H3. 4.  H3. 3 deposition into chromatin is mainly transcription-associated and DNA replication-independent, but it can also enter a replication-coupled pathway.  Although not essential for vegetative growth, minor H3 variants are required for producing viable conjugation progeny by affecting late developmental stages of conjugation.
What are the official names of this protein?
Histone H3.3, Minor histone H3 variant, hv2.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes mainly to the large, transcriptionally active, somatic macronucleus (MAC) and only faintly to the small, transcriptionally inert, germ line micronucleus (MIC).
Protein: UGTP_STAES
Sequence: MVTQNKKILIITGSFGNGHMQVTQSIVNQLNEMNLNHLSVIQHDLFMEAHPIMTSICKKWYINSFKYFRNTYKRFYYSRPNELDKCFYKYYGLNKLINLLIKEKPDLILLTFPTPVMSVLTEQFNINIPIATVMTDYRMHKNWITPYSQRYYVATKDTKDDFIEAGVPASYIKVTGIPIADKFEESIDKEEWLSQQHLDPSKPTILMSAGAFGVSKGFDYMINNILEKSPNSQVVMICGRSKELKRSLKAKFKDNPSVKILGYTNHMNEWMASSQLMITKPGGITISEGLSRCIPMIFLNPAPGQELENAYYFESKGFGKIADTPNEAIDIVSDLTNNEETLKVMSSKMLESKVGYSTRKICKDLLDLIGHSSQPDEIYGKVPLYARFFVK
What is the function of this protein?
Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids.  Is able to successively transfer two glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol).  Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).
What are the official names of this protein?
Processive diacylglycerol beta-glucosyltransferase, Beta-diglucosyldiacylglycerol synthase, Beta-DGS, DGlcDAG synthase, Glc2-DAG synthase, Beta-gentiobiosyldiacylglycerol synthase, Beta-monoglucosyldiacylglycerol synthase, Beta-MGS, MGlcDAG synthase, Diglucosyl diacylglycerol synthase (1,6-linking), Glucosyl-beta-1,6-glucosyldiacylglycerol synthase, UDP glucosyltransferase, UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. UgtP subfamily.
What are the subcellular locations of this protein?
Cell membrane.
Protein: AT2A2_FELCA
Sequence: MENAHTKTVEEVLGYFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYKKFGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKVMSVIREWGSGSDTLRCLALATHDNPLRREEMNLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKDDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEPAILE
What is the function of this protein?
Involved in the regulation of the contraction/relaxation cycle.  Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation.  Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation.
What are the official names of this protein?
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA2, SR Ca(2+)-ATPase 2, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CYMEB_MELDN
Sequence: GLPICGETCFTGKCYTPGCTCSYPICKKN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide mden-B.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: RK36_NASOF
Sequence: MKIRASVRKICEKCRLIRRRGRIIVICSNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CH10_YERPG
Sequence: MKIRPLHDRVIVKRKEVESKSAGGIVLTGTAAGKSTRGEVLAVGNGRILDNGEIKPLDVKVGDVVIFNDGYGVKAEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_ARTS2
Sequence: MDLFEYQARDMFEAHGVPVLAGIVAHTPEEAKAAAEKIGGVTVVKAQVKVGGRGKAGGVKVAKTADEALEHSTNILGMDIKGHTVNKVMIAQGADIAEEYYFSVLLDRANRNYLAMCSVEGGMEIEQLAVERPDALAKVAIDPAVGIDQAKADEIVAAAGFAEELRGKVADVILKLWDVFKKEDATLVEVNPLVKTGAGDIVALDGKVTLDENADFRHAKHALLEDKDAADPLEAKAKAQDLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGENHGNVKPANFLDIGGGASAEVMAAGLDVILGDEQVKSVFVNVFGGITACDAVAKGIVGALAELGHSANKPLVVRLDGNNVEEGRRILAEANHPLVTLAATMDEGADKAAELANAAK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: CH10_ACIBS
Sequence: MSNIRPLHDRVVIRRVEEETKTAGGILLPGSAAEKPSQGEVIAVGNGQITDNGVRALDVKVGDKVLFGTYAGTTVKVNGEELLIMKESDILAVLEG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGY0_YEAST
Sequence: MGIITLSGNVLHLLKAYPKKGLEEVSQPEPNTANDSSTEYKGKSKDDFQMVEKSNTDERYNFTRTKKWFLLMTSEYYKLMENRLLMFCIIACSFICAIQFLFFIIYWTNIVPRKTQRAITNLNYDYLTAHLKEQCVPYAKILDQCIL
What are the official names of this protein?
Uncharacterized protein YGL230C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NAAA_LYSSP
Sequence: XNVVFLNXPXPQW
What is the function of this protein?
Has bacteriolytic activity.
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase L2.
What are the subcellular locations of this protein?
Secreted.
Protein: PCKA_PSET1
Sequence: MTSSATRFVDLTAAELVEHAIRRGEGTLAANGAFVANTGHRTGRSPKDRFIVQESSTENEIQWGNVNRPFDADKFDALWARVEAYVQSNDHFISHLEVGADPEHYLPVVVTTETAWHHIFAKNMFIQPKSYNSSDVPQWQVMNVPSFVCEPERDGTNSDGTVLINFAQRKVLLAGMRYAGEMKKSMFSVQNFLLPAKGVLPMHCSANVGEAGDTALFFGLSGTGKTTLSADPTRFLIGDDEHGWAPGSVFNIEGGCYAKCIDLSQKNEPVIWDAIRFGTILENVVLDENRVPDFNDTSLTQNSRAAYPLEHVEKRKVENRAGEPKAVVFLTCDVSGVLPPVSILTEEAAAFHFLSGYTAKVGSTEIGSTSDIESTFSTCFGAPFFPRPAGVYAELLMKRVREFGAKVYLVNTGWTGGPYGTGKRFDIPTTRAVVDAIVSGKLVGVETQHIDVLNLDVPVAVPGVDSNLLNPINTWEDKAKYAEYAAKLAADFTENFTKYDVSDEIKNAGPKAQ
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLS4_PHAJA
Sequence: FLSLIPHAINAISAIAHHL
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Phylloseptin-J4, PLS-J4, PS-J4.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.