PharMolix/UniProtQA huggingface dataset:
Protein: VE1_BPV1
Sequence: MANDKGSNWDSGLGCSYLLTEAECESDKENEEPGAGVELSVESDRYDSQDEDFVDNASVFQGNHLEVFQALEKKAGEEQILNLKRKVLGSSQNSSGSEASETPVKRRKSGAKRRLFAENEANRVLTPLQVQGEGEGRQELNEEQAISHLHLQLVKSKNATVFKLGLFKSLFLCSFHDITRLFKNDKTTNQQWVLAVFGLAEVFFEASFELLKKQCSFLQMQKRSHEGGTCAVYLICFNTAKSRETVRNLMANTLNVREECLMLQPAKIRGLSAALFWFKSSLSPATLKHGALPEWIRAQTTLNESLQTEKFDFGTMVQWAYDHKYAEESKIAYEYALAAGSDSNARAFLATNSQAKHVKDCATMVRHYLRAETQALSMPAYIKARCKLATGEGSWKSILTFFNYQNIELITFINALKLWLKGIPKKNCLAFIGPPNTGKSMLCNSLIHFLGGSVLSFANHKSHFWLASLADTRAALVDDATHACWRYFDTYLRNALDGYPVSIDRKHKAAVQIKAPPLLVTSNIDVQAEDRYLYLHSRVQTFRFEQPCTDESGEQPFNITDADWKSFFVRLWGRLDLIDEEEDSEEDGDSMRTFTCSARNTNAVD
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: CLPX_THEPX
Sequence: MVKYDNQKQLKCSFCGKTQDQVKRLVAGPGVYICDECIELCQEIINEEFEEDIDMGIGELPKPKEIKEFLDQYVIGQEKAKKALAVAVYNHYKRINSRIKPDDVELQKSNILLLGPTGSGKTLLAQTLAKLLNVPFAIADATSLTEAGYVGEDVENILLKLIQAADYDIEKAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTIANVPPQGGRKHPHQEFIQIDTTNILFICGGAFEGIEKIIESRIGKKSLGFGAEVQSRKEKDLSEILSHIMPQDLLKFGMIPEFIGRVPIVVTLDPLSKDDLVRILTEPKNALTKQYEKLFELDGVKLEFDKKALGLIADMALERKTGARGLRAILEEIMLDVMYEIPSSDNIEKCIITEETVLKKAPPTLVYSDAQKAKKKIKKTESVS
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RL35_BART1
Sequence: MPKMKTKSSAKKRFKVTASGKIKVAAAGKRHGMIKRSNKFIRDARGTMVLCEQDAKKVIQHYLPNGL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: SYR_TREPS
Sequence: MQDLCEMWRHAVARVLSQLQGPAVEPVEGAQLVMEEPPEPGMGDIAFPLFLFAKRVRRSPAQLAQQLCTLLEEDTSMCAYGTPQARGPYLNVFLNKECVAAHTLDAIFAQGERYGHTQYLQGKRIMVEFSSPNTNKPLHVGHLRNNAIGESLSRIIAFCGADVFKVNIINDRGVHICKSMCAYQKFAHGKTPAHTGIKSDRFVGDWYVQFNRYAQQYPEEAEHDVRDLLQRWESADPHVRALWRTMNEWALRGIKQTYERTGISFDKLYFESETYTKGREEVRRGLACGVFYQMEDNSIWVDLSSLGLDKKALLRSDGTTMYITQDIGTAIFRAQDWPFDQLLYVVGNEQNYHFKVLFFVLRLLGYPWAQQLHHVSYGMVNLPHGRMKSREGTVVDADDILDRLHSAAEEEIAKKGRENALKHAQCIAENVAIAALHYFLLQVSPQKDMVFHPEESLSFNGNTGPYLQYMGARISSLLKKVQEDVEQKGPREVRCDPALLTHEAEWELVKALARFPACVTRAAQGHDPSVITGYLYTLSKSFSRFYHDCPILCEARPDYACARLELVRAVRIVLRTAMRLVLIPFLEEM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_MYCUA
Sequence: MARAVGIDLGTTNSVVAVLEGGDPVVVANSEGSRTTPSVVAFARNGEVLVGQPAKNQAVTNVERTMRSVKRHMGGDWSIEIDDKKYTTPEISARVLMKLKRDAEAYLGEDIADAVITVPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKGEKDQTILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDDRVVEWLVDKFKGTSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRITQDLLDRTRKPFQSVIADTGISVSDIDHVVLVGGSTRMPAVTELVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTKLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGVSQIEVTFDIDANGIVHVTAKDKGTGKENTIRIQEGSGLSKDEIDRMIKDAEAHAAEDHKRREEADVRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKSALAGTDIAAIKSAMEKLGQESQALGQAIYEATQADAAAAGAPGGQPGGAEPGADDVVDAEVVDDDQESK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: LUXE_PHOLU
Sequence: MTSYVDKQEITASSEIDDLIFSSDPLVCAYDEQEKIRKKLVLDAFRHHYKHCQEYRHYCQAHKVDDNITEIDDIPVFPTSVFKFTRLLTSNENEIESWFTSSGTNGLKSQVPRDRL
What is the function of this protein?
Acyl-protein synthetase activates tetradecanoic acid.  It is a component of the fatty acid reductase complex responsible for converting tetradecanoic acid to the aldehyde which serves as substrate in the luciferase-catalyzed reaction.
What are the official names of this protein?
Long-chain-fatty-acid--luciferin-component ligase, Acyl-protein synthetase.
What is the protein family that this protein belongs to?
Belongs to the LuxE family.
Protein: Y1168_SULIK
Sequence: MVKVMVVAEVRPSEDVNKVLSAISNFFDFEKTNTRKEGIIDILVLEARTLKSLLKFHRVLRNERILDSARKYLMKGIEGNTIAFMIHKQAAAVGVLSFVDNDKESPLGAIKFYIEYQNPKEVVDWLAPRTAHGVPLWDNPIPPDV
What are the official names of this protein?
UPF0201 protein M164_1168.
What is the protein family that this protein belongs to?
Belongs to the UPF0201 family.
Protein: METL5_MOUSE
Sequence: MKKLKLKELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSNRMSKLFDTVIMNPPFGTKNNKGTDMAFLKTALGMARTAVYSLHKSSTREHIQKKAAEWKVKIEIIAELRYDLPALYNFHKKKSVDIEVDLIRFSF
What is the function of this protein?
Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:32783360, PubMed:35033535).  N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (PubMed:32783360, PubMed:32217665).
What are the official names of this protein?
rRNA N6-adenosine-methyltransferase METTL5, Methyltransferase-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Nucleus. Presynapse. Postsynapse.
Protein: METN_MANSM
Sequence: MIKLKNISKIFDVAGKKLNALDNVSLDIPKGDICGVIGASGAGKSTLIRCVNLLERPTSGSVFVDGQDLTQLSEAQLIAERRNIGMIFQHFNLLSSRTVYENVALPLTLEHMAKEKIHEKVTALLALVGLTDKKDVYPANLSGGQKQRVAIARALASDPKVLLCDEATSALDPATTQSILKLLKEINRTLGITILLITHEMDVVKNICDQVAVIDKGQLIEQGSVSEIFSNPKTELAQEFIRSTFQANLPEEYLAKLTDTPKRSDSYPIIRFEFTGRSVDAPLLSQTSRKFNVSFNILVSQIDYAGGTKFGFTIAEVEGDEDSITQAKIYLMESNVRVEVLGYVD
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LIPA_CHLT2
Sequence: MTDSESPTPKKSIPARFPKWLRQKLPLGRVFAQTDNTIKNKGLPTVCEEASCPNRTHCWSRHTATYLALGDACTRRCGFCDIDFTRNPLPPDPEEGAKIAESAKALGLKHIVITMVSRDDLEDGGASALVHIIETLHTELPTATIEVLASDFEGNIAALHHLLDTHIAIYNHNVETVERLTPFVRHKATYRRSLMMLENAAKYLPNLMTKSGIMVGLGEQESEVKQTLKDLADHGVKIVTIGQYLRPSRRHIPVKSYVSPETFDYYRSVGESLGLFIYAGPFVRSSFNADSVFEAMRQRETSTSSLLPNKD
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD_ACIF5
Sequence: MPEINNFTMNFGPQHPSAHGVLRLVLELDGEVIERADPHIGLLHRATEKLAENKTYLQNLPYMDRLDYVSMLCNEHAYCLAVEKLLGVEVPVRAQYIRTLFDEITRILNHLLWLGAYALDVGAMSVFLYCFREREDLMDVYEAVSGARMHAAYYRPGGVYRDLPAQMPQYQPSPYRDARRLQELNANRQGSMLDFIEDFARRFPTYVDEYETLLTDNRIWKQRTVGIGVVGPERAIQLGFTGPMLRSSGVAWDLRRTQPYAAYADLDFDIPVGKTGDCYDRYLVRVAEMRQSNRIIVQCVDWLRKNPGPVITDDFKIAAPSREEMKTSMEALIHHFKLFSEGMAVPAGEVYAAVEAPKGEFGIYMISDGANKPYRMKIRAPGFPHLAAMDEMARGHMIADVVAILSTMDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MQO_BACAN
Sequence: MSNMQQKTDVILIGAGIMSATLGSLLKELAPEWEIKVFEKLASAGEESSNEWNNAGTGHSALCELNYTSEKSDGSIDISKAVKVNEQFQLSRQFWAYLVKSKLIRNPQDFIMPLPHMSLVQGEKNVEFLKNRFEALSKNPLFQGMEFSDAPETLKKWLPLIMEGRTSNEPMAATKIDSGTDVNFGALTRMLFDYLKTKDVELNYKHSVENIKRTKNGLWEVKVHDMNSGKIEHHTAKFVFIGGGGGSLPLLQKTGIPESKHIGGFPVSGLFMVCKNQKVVEQHHAKVYGKAKVGAPPMSVPHLDTRYIDNKKALLFGPFAGFSPKFLKTGSNLDLIGSVKPNNVLTMLAAGVKEMGLTKYLIQQVMLSHEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTDAGGKGTLQFGTEVVSAADGSIAALLGASPGASTAVHVMLEVLEKCFPSRMVEWEGKIKEMIPSYGISLTENPRLFQDLHTSTGRTLGLNEKETVHN
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: HEM1_LISMO
Sequence: MFILTMGLNHHTAPIDIREKLVFKETEEEMALVTLQQEKSILENVIISTCNRTEIVAVVDQIHTGRYYLKRFMANWFQMDMEKIEPYLFFHEETEAVNHLYKVTAGLDSLVLGETQILGQVKHAFEIAKQTETTGTLLNKLFREVVTFAKKVHHHTKINENAVSVSYAAVEVAKKLYGSLDNKKIVLVGAGEMSELALQNLAGSGIADITIINRTKSNAELLANQFQAKVGAYENMNEHLMLADIVLVSTSATEPIIKQAAMQDLMEQKASSMLVIDIGLPRNVEHDCSYIPNFHLYDIDDLAGVVSANSLERQRIVLELENTIEVEVRNFFEWEKQLGVVPVIRALREKALDMQEVAMTSLENKLPGLTEREYIQIGKHMKSIINQMLKQPISELKEMSVEEDATTSIEHFKRIFGLSETDVTVIEKEQAETRS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: TIG_PSEA6
Sequence: MQVSVETTQGLERRLTITVPAESIDSQVKSRLQQLAKTQRINGFRPGKVPVSVIKKRYGQAVRQEIAGEAMQRNFYEAIVQEKITPAGMPNFEMKTDVDGQDLEFVAAFEVYPEVEVKDVEKIEVEKPVVEITDADLETMMETLRKQHATWKEVKRKSKKDDRVTVDFVGTIDGEEFEGGKAENFELEMGKDRMIPGFEKPIVGAKAGEEVVADVTFPEDYHAEALKGKEAQFKITVNKVEGLSLPKVDEEFAKLFGVEDGDVEALNAEVRKNMQRELEQTLKANVKEQVIEGLLANNEIDLPKALVDQEINALREQAKQRFSQQQGGNVDNLPELPADLFQENARKRVSIGLLLGEIIKTEELKVDSAKVDALIETAASAYEDPQEVIEYYKTNDELMQQMQNVALEEQAVEVLLSKANVKEVNKAFDEIMNKQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: DAPAT_LEPBJ
Sequence: MANINENYLKLKAGYLFPEISKRVKTYSEKNPSAKIIRLGIGDVTLPIVPSVVDAMIAASKEMGTAGGFHGYGPEQGYSFLLKSIANNDYGSLGIKIDESEIFVSDGSKCDCGNIQEIFSTDAKIAVSDPVYPVYVDTNVMAGRTGEIGADGRYSNLIYMPATKENGFQPEIPKEKADIIYLCYPNNPTGTVTTKEALRAWVEYAKKNNSIILYDSAYEAFISEPGVPRSIYEVAGAKEVAIEFRSFSKTAGFTGLRCAYIVIPKELKGRTRGGEEVSINSLWSRRHTTKFNGVSYVTQKGAEACYSPQGKKEIQASIAYYMSNAAKIREGLKKAGYEVFGGVNAPYIWLKTSDNLSSWDFFDRLLDKAQVVGTPGSGFGPAGEGYFRLSAFGKKEDVEEAIARISFL
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: ACTN2_CHICK
Sequence: MNSMNQIETNMQYTYNYEEDEYMTQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHLSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHEQWAYGKEQILLQKDYESASLTEVRAMLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAASVNDRCQKICDQWDSLGTLTQKRREALERTEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLISAHDQFKATLPEADGERQAILSIQNEVEKVIQSYSMRISASNPYSTVTVEEIRTKWEKVKQLVPQRDQSLQEELARQHANERLRRQFAAQANVIGPWIQTKMEEIARSSIEMTGPLEDQMNQLKQYEQNIINYKHNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNDFRASFNHFDRRKNGLMDHDDFRACLISMGYDLGEAEFARIMSLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILADELRRELPPEQAQYCIKRMPQYTGPGSVPGALDYTSFSSALYGESDL
What is the function of this protein?
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures.  This is a bundling protein (By similarity).
What are the official names of this protein?
Alpha-actinin-2, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein.
What is the protein family that this protein belongs to?
Belongs to the alpha-actinin family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, Z line.
Protein: DXS_BRUME
Sequence: MSRPSTPLLDKAPTPDRLRALPEQDLPQLAEELRTELIDAVSTTGGHLGAGLGVVELTVALHHVFNTPYDRIIWDVGHQAYPHKILTGRRDRIRTLRQAGGLSGFTKRAESEYDPFGAAHSSTSISAGLGMAVASELSGEKRNVIAVIGDGSMSAGMAYEAMNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLVSGRTYRSVREAAKQVAQKLPKFLQDKARKSEEYARAFFTGGTLFEELGFYYVGPIDGHNLDHLLPVLKNVRDTQKGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGKQAKPPANAPSYTKIFGTSLIEEARHDDKIVAVTAAMPTGTGLDLFGEAFPKRVFDVGIAEQHAVTFAAGLASEGYKPFCAIYSTFLQRGYDQVVHDVSIQNLPVRFPIDRAGLVGADGPTHAGSFDTGFLAALPGFVVMAASDEAELRHMVRTAAEYDEGPISFRYPRGDGVGVDLPERGSVLEIGKGRIVREGTKVALLSFGTRLQECLAAAEELGAAGLSTTVADARFAKPLDHDLIRRLAREHEVLVMVEEGAVGGFGSHVLQFLATDGLLDRGFKVRALTLPDIYQDHGKPDAMYAEAGLDRTGIVRTVFAALHRDELGHEALPTPFRA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: GPN_PYRAB
Sequence: MIVVFVGTAGSGKTTLTGEFGRYLEDNYKVAYVNLDTGVKELPYEPSIDVREFVTVEEIMREGYGPNGAIVESYDRLMEKFNEYLNKILRLEKENDYVLIDTPGQMETFLFHEFGVRLMENLPYPLVVYISDPEILKKPNDYCFVRFFALLIDLRLGATTIPALNKVDLLSEEEKERHRKYFEDIDYLTARLKLDPSMQGLMAYKMCSMMTEVLPPVRVLYLSAKTREGFEDLETLAYEHYCTCGDLT
What is the function of this protein?
Small GTPase that may be involved in genome maintenance.  Has weak intrinsic GTPase activity but displays no ATPase activity.
What are the official names of this protein?
GPN-loop GTPase PAB0955.
What is the protein family that this protein belongs to?
Belongs to the GPN-loop GTPase family.
Protein: ENO_BACSU
Sequence: MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTGEYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTENKGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNVDIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEALQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEELVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGNSILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTGAPSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate at Lys-339; once secreted, it remains attached to the cell surface.
Protein: SDHE_SALTY
Sequence: MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRNRERGPVAI
What is the function of this protein?
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins.  Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
What are the official names of this protein?
FAD assembly factor SdhE.
What is the protein family that this protein belongs to?
Belongs to the SdhE FAD assembly factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUMO2_RAT
Sequence: MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.  Plays a role in the regulation of sumoylation status of SETX (By similarity).
What are the official names of this protein?
Small ubiquitin-related modifier 2, SUMO-2, SMT3 homolog 2, Sentrin-2, Ubiquitin-like protein SMT3A, Smt3A.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body.
Protein: SYA_PELTS
Sequence: MTGNEIRESYLKFFEKKGHKILPSASLIPLNDPSILWTAAGMVPFKPFFTGAAKPEYTRVTTCQKCIRTPDIESVGKTARHHTFFEMLGNFSFGDYFKESAIPWAWEFVTEHLRLPADKLWISIFLDDDEAFEIWNKTVGVPAGRIVRMGKDTNFWEIGVGPCGPCSEIYVDLGAERGCGSPECKVGCDCDRFLEIWNLVFIQFFKDEEGNYTPLTSKGIDTGFGLERVASVMQGVPTNFDTDLFREIMDFTAGLFGLKYGVDGRVDVALKVIADHCRAITFAVADGALPSNEGRGYVIRRLLRRAVRFGRLLGIEDPFLHEVSGAVVRQMGRVYPELVTQREHVFRVIRREEERFGETLAQGTEMLNRLIAEARQAGSAVVSGEDAFRLYDTYGFPLELTQEMAGEQGLTVDTDGFGRAMEEQRQRARSARQETDYISGRDAMFKKMREEVGETVFVGYDALEATGRVLRIVQGGKRLESAQAGEEVEFILDVTPFYAESGGQVSDRGKVTAADLEVEIHEVTKPVENLFVHRGKVVAGILKEHDTVTARVDPARRAATCRNHSATHLLHKALKEVLGGHVNQAGSLVEPERLRFDFTHYAAATPEELQKVEELVNRMVLSALPVEAFETSLAEARKMGAAALFGEKYGERVRVVKMGDFSLELCGGTHLRNTAEVGLFKLLGESSVGAGLRRIEAVTGEGALSYVKAKEEQLAEIARLVKAAPHEAVRRVEGLLQTVRDLEAENEALQARLARYQVQDLMDRLREVKGVKVLAGQAAAPDMDSLRGMVDLLRDRVGSGVIVLGSAGENRVNLVAAVTKDLVEKGLHAGKLVKELAPVVGGGGGGRPEMAQAGGKDPSRLKEALEKTYKAVESQLK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_ECOUT
Sequence: MAKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLDNAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDEEGRALLAAFDFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RIMK_ECOSM
Sequence: MKIAILSRDGTLYSCKRLREAAIQRGHLVEILDPLSCYMNINPAASSIHYKGRKLPHFDAVIPRIGTAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAHSPDDTSDLIDMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIKEAQGCDIRCLVVGDEVVAAIERRAKEGDFRSNLHRGGVASVARITPQEREIAIKAARTMALDVAGVDILRANRGPLVMEVNASPGLEGIEKTTGIDIAGKMIRWIERHATTEYCLKTGG
What is the function of this protein?
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF).  Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate.  The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
What are the official names of this protein?
Ribosomal protein S6--L-glutamate ligase, Poly-alpha-glutamate synthase, Ribosomal protein S6 modification protein.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: PSIE_ECOLU
Sequence: MTSLSRPCVEFISTILQTVLNLGLLCLGLILVVFLGKETVHLADVLFAPEQTSKYELVEGLVVYFLYFEFIALIVKYFQSGFHFPLRYFVYIGITAIVRLIIVDHKSPLDVLIYSAAILLLVITLWLCNSKRLKRE
What are the official names of this protein?
Protein PsiE.
What is the protein family that this protein belongs to?
Belongs to the PsiE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.