PharMolix/UniProtQA huggingface dataset:
Protein: GREA_CHESB
Sequence: MNKVPMTLAGYESLKEELRWRQQEERPRIIEAIAEARAHGDLSENAEYHAAKEAQSLNEGRISELEDLIARAEVIDVTKLSGDTVKFGATVVLVDEDTEEEKTYQIVGDQEADVKSGRISISSPIARALIGKGVGDLIEVNAPGGARGYEVLRVQYG
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RL19_EXIS2
Sequence: MNTQQLFREITQEQIKSDVPAFRPGDTVRVHVKVVEGTRERIQLFEGVVIKRHGGGISETFTVRKISYGVGVERAFPLHSPRVAQIEVVRYGKVRRAKLYYLRNLRGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RL15_EHRRW
Sequence: MDVVMKLNNIFSGLPKKKKSKVLGRGIGCGKGKTSGRGHKGQKARSGVSINGFEGGQQSIFTRLPKRGFNSLPKNKYSIINLSLIQRLIDSGKIDNVSAITKEVLYNLGVISSVKQKIKILGDGKLNTTVCIEYDFISKSAKSQVTLLNSLSDSESK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PITX2_MOUSE
Sequence: METNCRKLVSACVQLGVQPAAVECLFSKDSEIKKVEFTDSPKSRKESASSKLFPRQHPGANEKDKGQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
What is the function of this protein?
Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis.  During embryonic development, exerts a role in the expansion of muscle progenitors.  May play a role in the proper localization of asymmetric organs such as the heart and stomach.  Isoform Ptx2c is involved in left-right asymmetry the developing embryo.
What are the official names of this protein?
Pituitary homeobox 2, ALL1-responsive protein ARP1, BRX1 homeoprotein, Homeobox protein PITX2, Orthodenticle-like homeobox 2, Paired-like homeodomain transcription factor 2, Paired-like homeodomain transcription factor Munc 30, Solurshin.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNY_STRS2
Sequence: MNIITVVVTLVSALIGLVLGYFAISLKMKSAKETAELTLLNAEQEASNVRGRAEEQAEVILKTAERDRQTLKKELLLEAKEEARKYREEIAEEFKSERQELKQIESRLTERATSLDRKDDNLTNKEKTLEQKEQSLTDKAKHIDEREQEVVKLEEQKALELERVAALSQEEAKEIILTDTRDKLTHEIATRIKEAEREVKERSDKMAKDLLAQAMQRISGEYVAEQTITSVHLPDDAMKGRIIGREGRNIRTFESLTGIDVIIDDTPEVVVLSGFDPIRREIARMTMETLLQDGRIHPARIEELVEKHRVEMDNRIREYGEAAAYEVGAPNLHPDLIKIMGRLHFRTSYGQNVLRHSIEVAKLAGVLAAELGENVNLARRAGFLHDVGKAIDREVDGSHVEIGTELAKKYKENPIVINAIASHHGDVEATSTIAVIVAAADALSAARPGSRRESMEAYIKRLQDLEEIANSFEGIKQSYAIQAGREIRIIVHPNKVTDDQITILAHDVREKIENNLDYPGNIKITVIRETRATDVAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: GCSH_CHLTE
Sequence: MNIPDNLRYTKDHEWIKLLEDGLTALVGITDFAQSELGDIVFVETKPVGTKVAAHGTFGTVEAVKTVADLFAPAAGEIVEVNAGLDDAAIVNSDPYNEGWIVKMKLDNPADVEALLSPADYSALIGE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: MED4_CANAL
Sequence: MLPFKKADSPFKSNPVSRVGSSTRLNQLGNIKSNPTTPNAALYVTSSLNPSKNLPTNAANVKSRLQTQKDLDAFKQLPMVQKVNEYERLLNELSEAVSQFKNDELQEKIGQIITCNDVLKQQIEDLNKHRNYSYEVDKLSDRNKILEENSKFILKELVSYRNELKKLPKLPKSDKMVNRNVDVDDILKYAFKLAKFTKAPATVANMPFQIHPNNYVWPAEDSLRRGMLAQASLQAEEIIRHELGETDKENSNEVKTESKVDHDDDDDDEMEDVRISNENTNDEQRSKPPAASEHDTSKRKEEQNQQPVDLNLDLFDPDDEYSD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 4, Mediator complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECA_MYCGA
Sequence: MLINWFKLISPKNRILKRATLAAKQVDALKDEMRALSDEQLFNKTEYFINELKNNKTTDDILVEAFAVIREVVYRETGNFAYLVQLIGAYVVHQGDFSEMMTGEGKTLTLVLAAYLNMLEKKGVHIVTVNEYLAERDAEQARRIFARLNLTVGCNKANLAPHLKKEAFDCDLTYTTNSELGFDYLRDNMVRNYRDKKIRGLHFAIVDEGDSILIDEARTPLIISGQPKKDFRMYFDADKFVETLSESDYKIDPESRSPSLTEKGITKAEKHFKINNLFDLENSDLFHKIGNALTARKIFQNGKEYIVRDDKILIVDHFTGRILEGRSYNGGLHQAVQAKERVPIEAENVVVATVTYQSFFRMYKKLAAVSGTALTESEEFLKIYNMVVVPVPTNRPVIRKDHPDFMFGNLKTKWEAVVNEIEKIHKTGQPILVGTGSVEDSETLHQMLLEKNIMHEVLNAKNHAREAHIIAKAGEVGSVTISTNMAGRGTDIKLGKGAKELGGLYVIGTERHESRRIDNQLRGRSGRQGDIGESRFFISFGDPLFKRFAQDRILKAQEKLASDYFDSKFFSRFLTMTQKKVESVNFDMRKNLIDYDHVLANQRELIYKQRDKILIASDLTEVVDRMAQNFVEGFVETFKDQANQTMVNPIELSIAVQKELLQGEEVTASQFYNQTLLAAKQTVLKLVKDAISKKIEVMTVGIANNVFRDIIIQQMDDAWIHHLDQMLKLREGVSLRSLEQTSPLNIYVEESKKLFDLMLNKIAKNVILAVCAIINPTRNVDINVEQEHRRLEALKRLEEIKKLEELQNNNNEPAKVLFKFPDQHGNMIEREVPVDNLIQLVDGQIIQAQVAEEPKQELNQLEKADQLDQTLIEAKLAEQQEQKNNSATDK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: SGTA_MOUSE
Sequence: MDNRKRLAYAIIQFLHGQLRHGGLSCDAQESLEVAIQCLETAFGVTLEDSDLALPQTLPEIFEAATSSKQEMPQDPRAPDRTPPSEEDSAEAERLKTEGNEQMKLENFEAAVHLYGKAIELNPANAVYFCNRAAAYSKLGNYVGAVQDCERAIGIDPGYSKAYGRMGLALSSLNKHAEAVAYYKKALELDPDNDTYKSNLKIAELKLREAPSPTGGVGSLDIAGLLNNPHFITMASSLMNSPQLQQLMSGMISGGHNPLGTPGSSPQQSDLASLIQAGQQFAQQMQQQNPEFVEQIRSQVVRSRTPSASHEEQQE
What is the function of this protein?
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol.  Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails.  Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module.  Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins.  It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states.  Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex.  Binds directly to HSC70 and HSP70 and regulates their ATPase activity.
What are the official names of this protein?
Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT.
What is the protein family that this protein belongs to?
Belongs to the SGT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis.
Protein: RB22A_CANLF
Sequence: MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQEAFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVKELRQHGPPNIVVAIAGNKCDLIDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSADANPPSGGKGFKLRRQPSEPQRSCC
What is the function of this protein?
Plays a role in endocytosis and intracellular protein transport (PubMed:11870209, PubMed:16537905).  Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905).  Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity).  Binds GTP and GDP and has low GTPase activity.  Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:11870209).
What are the official names of this protein?
Ras-related protein Rab-22A, Rab-22.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Early endosome. Late endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or Mycobacterium.
Protein: ACUK_EMENI
Sequence: METETGKGATAPPAESSGVEQDTAAVGAPADQPPKTNANATSNANGEDQPANGQKANPKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPDGALMPGIGGNNFYNNNSMSNGVPSGGINMNGANTVNSAASTQNSSANFYPTPQSNYSLYQENPINHQNSFPSQSPVSPTFSLKTNPTPRNTAPNNNNNNALTSSMPQPATTGVSNAPNQSQNPFAGPFFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPDSGTHRGSMGRSGSTQFASTPIGGTTTFGESPQNQQPFMFGDPLLNEWPSGQTSGQPHVNVGVYPQSSQGNVIPGHLSKPDAPHAFAIESGPNNFTSPGAATSPQINSGGYEDANAFNNVVTKSNGLSVNGQQRPPTISTPSLKHQSLQMNKRRHRNPSAVYESVKEPYAYTSRFHSLTAFIQRRFSPQKTLQIAKALASIRPSFIATTKTLNRDDLIFMEKCFQRTLWEYEDFINACGTPTIVCRRTGEVAAVGKEFSILTGWKKEVLLGKEPNYNVNTGGSSAANSRNITPRSSVESTGRPHPVFLAELLDDDSVVEFYEDFARLAFGDSRGSVTTRCKLLKYKTKEDMEAAQSDDNGQRWNNHLRKGGIANEAGMNQLGFKDGKVECAYCWTVKRDVFDIPMLIVMNVRLPLP
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes like acuF, acuG and acuN.
What are the official names of this protein?
Transcription activator of gluconeogenesis acuK, Acetate non-utilizing mutant protein K.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LSPA_LEPBL
Sequence: MKYFEKRFLDVYRPLYIGVIFLGIILDLVTKFLVILYFEPHRYLEVLGSFFRMTLTFNTGFVFGAFQDNAIPSLIATGIAIVFLIGYRWKNYDLGNPWGWNLVMAGAFGNFLDKFFVKIPGTGFRFGFQPNVGEYIGVVDFLDFDWPDFLLFSRWPAFNVADSCVTIGLTILIFTMKLEEEK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RELX_HYPSI
Sequence: WPRGPDYTERRVMCGLQYVRAAISICGPNMQTMRPRNGSGPIVPPPDFLAMYGMARYKPPLSKKCCSTGCNREDFRGYCYL
What is the function of this protein?
Uncertain.
What are the official names of this protein?
Relaxin-like protein AGF.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS20_STRMK
Sequence: MANIKSAKKRAKQTVVRNARNVAQRSMLRTAVKKVIKALDANDAAGAEAAFAVAQPILDRFSARGLIHKNKAARHKSRLNDRIKALKAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: HAKAI_CHICK
Sequence: MDHNDNDLQGTNSSASLGGLDVRRRIPIKLISKQTNKTKPAPRAPRAMNRMPAKTQAGDEEEFDFNEEERYECKGGEMFGNQRRFPGPIFWDYKINLLGEKDDTPVHFCDKCGLPIKMYGRMIPCKHVFCYDCAILHEKKGDKMCPGCNEPVQRIEQCVRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRPPLEPVHPPIAPPPAEIPERFIMPPEKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRPPPAEMSMAPPPPRPVSQDTFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVTHPHHIMPPQQHYAPPPPPPPPISHPLQHPPQAAGTPHMVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVNVSAPPPHHYNPNSLPQFSEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRMQGPPAQAPLAGPHHPDQARYRPYYQ
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates.  Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.
What are the official names of this protein?
E3 ubiquitin-protein ligase Hakai, Casitas B-lineage lymphoma-transforming sequence-like protein 1, c-Cbl-like protein 1, RING-type E3 ubiquitin transferase Hakai.
What is the protein family that this protein belongs to?
Belongs to the Hakai family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm.
Protein: CTX15_LACTA
Sequence: MKYFVVALALVAAFVCIAESKPAESEHELAEVEEENELADLEDAVWLEHLADLSDLEEARGFFGNTWKKIKGKSDKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKYYGKKALQKASEKL
What is the function of this protein?
Insecticidal, cytolytic and antimicrobial peptide.  Forms voltage-dependent, ion-permeable channels in membranes.  At high concentration causes cell membrane lysis (By similarity).
What are the official names of this protein?
M-zodatoxin-Lt8e, M-ZDTX-Lt8e, Cytoinsectotoxin-1e, CIT-1e.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 06 (cytoinsectotoxin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: LUTB_ALKCK
Sequence: MAIKISDAPFSKRVEKGLQDGFMRQAVSSAQERLKTSKGSAEKELGNWEEWRTLAEEIRSHTLNHIDFYLHQLSENVEKAGGHVYFAQTAEEANQYIKEIVSSKEAQKVVKSKSMVTEEISMNKALEDIGCEVIETDLGEYILQIDDHDPPSHIVAPALHKNKEQIRDTFKARKGYTKSENPQELTLFAREQLRKEFLSADVGITGCNFAVAESGSISLVTNEGNARLATALPKTHIAVMGMERIVPTWEELDILVSMLCRSAVGQKLTSYVTGLTGPREDGDADGPEEFHLVIVDNGRSNILGTEFQAALHCIRCAACINVCPVYRHVGGHSYGSIYPGPIGAVLTPLLEGYEDHKELPYASSLCAACTDACPVKIPLHELLIKHRRVIAEQKRTARTEALAMKGFGIGASSPMLYKAGTKVVPFLLFPFVKDGAIPKGPGPLKGWTDVRHLPAPAKERFRDWFKARQKEGAHD
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.  Has probably a role as an electron transporter during oxidation of L-lactate.
What are the official names of this protein?
Lactate utilization protein B.
What is the protein family that this protein belongs to?
Belongs to the LutB/YkgF family.
Protein: KDPA_HALS3
Sequence: MASPPPIVEYAVFFTILAVLVFVAGEYLAWVYREQANSDHRPPGYLSWFERLDEIFTPIENGLYRLSGINPRREMTWKGYLKAVLVFNVCIWVLLFVVLMFQDALPMNFVGVGGESWDLAFHTASSFTSNTNQQHYSGETLSVFTHTFGIGIAMFLTPATGLALMPAFARAFTNKEDPRLGNFYENVVRGLVRFLLPISLLIAIILMAEGSVQTILGGQLTANTFTMGIQNIRIGPHAGIEAIKMFGTNGGGINAANAATAFENPTPLSNLVLTLAMPIGTFSAIYAWGAWVGNRSHGVAIVAAFFVIYMALTGVAVVGETGTNAGMVVTGNGLHVDQTVGNMEGKETRFGPTASAIWGLSTTGTTNGGVNSMHNSWTALGAFSLLFAFATNNISNGVGTGLLNILMFVILTAFIGALMIGRRPQYLGKKLEWQEMRYVFVVILVLPILVLIPQAAAVVYQGAIDSMNNPGFRGFSEVLYEFFSASANNGSGFEGLGDGTLFFNLVNGVQVLLARYVPITAQLAIAGYLANKKVSPESKGSLDTDTPAFVGLLIGVIIIVSALVFLPALVFGPIGELLSGGI
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel (By similarity).  The Kdp system is essential for growth under K(+) limitation, and for survival under desiccation and salt crystal inclusion (PubMed:18633573, PubMed:23757278).
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAT1_CLOPF
Sequence: MKFNLIDIEDWNRKPYFEHYLNAVRCTYSMTANIEITGLLREIKLKGLKLYPTLIYIITTVVNRHKEFRTCFDQKGKLGYWDSMNPSYTVFHKDNETFSSIWTEYDENFPRFYYNYLEDIRNYSDVLNFMPKTGEPANTINVSSIPWVNFTGFNLNIYNDATYLIPIFTLGKYFQQDNKILLPMSVQVHHAVCDGYHISRFFNEAQELASNYETWLGEK
What is the function of this protein?
This enzyme is an effector of chloramphenicol resistance in bacteria.
What are the official names of this protein?
Chloramphenicol acetyltransferase, CAT.
What is the protein family that this protein belongs to?
Belongs to the chloramphenicol acetyltransferase family.
Protein: GGACA_DANRE
Sequence: MIAIHILLLVFSNIVLPALCINVFVYGTLKKGQSNYHELTNTTHGQAEFITCARTKDPYPMVIATKDKFPFLLNVPGSGQQVYGEIYNVDQNMLDFLDEFEECPDLYQRTSIQLKILKGNGDSEEAFVYSTSTFDPDWLNKPTFSVYDATGDPGNNCVSRE
What is the function of this protein?
May contribute to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue.  Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.
What are the official names of this protein?
Gamma-glutamylaminecyclotransferase A, GGACT A, AIG2-like domain-containing protein 1-A, Gamma-glutamylamine cyclotransferase A, Gamma-glutamylamine cyclotransferase, tandem duplicate 1.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamylcyclotransferase family.
Protein: IF_HUMAN
Sequence: MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIAMNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENWAPSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
What is the function of this protein?
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum.  After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.
What are the official names of this protein?
Cobalamin binding intrinsic factor, Gastric intrinsic factor, Intrinsic factor, IF, INF.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic cobalamin transport proteins family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1665_HAEIN
Sequence: MPLIKVKSSAESLRNGGVGYYPTSNFIHVDTGPVRTWKGV
What are the official names of this protein?
Uncharacterized protein HI_1665.
Protein: EXO5_BOVIN
Sequence: MAETEEEETVSEEASGFSDLSDSELLDLEDTQESSASASKPGPSYELPGKDDKLIRSPKWKRRLDVSSPMERFHLKYLYVTDLSTQNWCEQQMVYGKEFSGFLTPEKSAILDTGASIHLARELEVHDLVSIPITSKEDAWAVKFLNILSMIPTLQSEGRIREFPVFAEVEGVLLVGVIDELHYTASGELELTELKTRGNPVLPSDAQKKKDYFQVSLYKYIFDAMVQGKVTAASLIHHTKLDPEKPLGPSVLRHAQQGGYSVKSLGDLIELVFLSLTLSDLPLIDSLKIEYVHQGTATVLGTEMVAFAEKEVRSKVQHYMTYWMGHREPQGVDVEEAWKCRMCNYADICEWKKSGGLISATLEPQVKKAK
What is the function of this protein?
Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair.  Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage.  Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends.  Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity (By similarity).
What are the official names of this protein?
Exonuclease V, Exo V, Defects in morphology protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the EXO5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Note=Localizes to repair foci in response to DNA damage.
Protein: FMT_VEREI
Sequence: MKVVFAGTPGFARVALQRLLDAGFSLPLVLTRPDQPAGRGLQWQASPVKQCALAHGLAVAQPRSLRLDGRYPQDAAAARAALLAAQAEVMVVAAYGLILPQWVLDLPARGCLNIHASLLPRWRGAAPIQRAIEAGDTHTGVTIMQMDAGLDTGAMLLSQGSAIAPTDTTATLHDRLAALGADLIVQALEKMAAGADLPALAQPAQGVAYARKIEKSESSIDWSLPAQRIGQRIRAFDPAPGASTTCNGTSIKLWGYAIDGATIDGQRGVPRMHPGQILSADDSGIAVACGQGTALRLTVLQRAGGKRLAAADFLRGFALQPGMWLGAARA
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: ATPE_LEPBL
Sequence: MFAHKLNVSVISPEKILYKGEVDSLVVPGSEGFFGILPNHAPLVATLGIGVLEIRKGEKLKNISVEGGFIEVKDNTVSILTDHGALKEDIDIEAEKKALAEVEKLSPSDSKNLLLQKTKTRILVASR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DPO4_NEIMA
Sequence: MSSRKIIHIDMDAFYASVELREQPHLKGRPVVVAWEGARSVICAASYEARQFGLHSAMSVATAKRLCPQAVYVPPHFDLYRQVSAQIHAVFRRYTDLIEPLSLDEAYLDVTRNFKNIPYASEVAKEIRAAIFAETGLTASAGIAPNKFLAKIASDWRKPNGQFVLPPHKVMAFLETLPLGKIPGVGKVTLKKMQSLGMQTAGDLRRFERGELLNHFGRYGYRLYDLARGTDERPVKAERECLQISTEITLPEDLPLEQAAGHLPHLAEDLWRQITRKNVEAQSVTLKLKTYDFRIITRTLTYSSVLPDCTALLQAAQMLMARVPPQTEDAFRLIGIGVGHLVPKNQQQDLWA
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_CHLT2
Sequence: MSRKARDPIVLPQGVEVSIQNDEISVKGPKGSLTQVLAKEVEIAVKGNEVFVAPAAHVVDRPGRMQGLYWALIANMVKGVHTGFEKRLEMIGVGFRAAVQGSLLDLSIGVSHPTKMPIPTGLEVSVEKNTLISIKGINKQLVGEFAACVRAKRPPEPYKGKGIRYENEYVRRKAGKAAKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.