PharMolix/UniProtQA huggingface dataset:
Protein: NAGS_SCLS1
Sequence: MPLSLSSRVREELAKETCEKLSTQHQAKKKAKAIDRDFFLSVLGSSATKREARSYIQNFKPPNTAPTKSKIQESTQQNSTENGANLGSIYTATRAVAESPKFVQQPVLPKPAPEGPLLHVALVKIRAPQLLDDETLSGIGKTLSRLSRLGLVSTVVVDGDDGSDTFLRISNCEWRNMVKEQAARVVAAIDASGTEARLVDNVIGIAEDGSNFEQRPYLKGRVHVTLRELLMTPLRRGVLPIIPSIGHTDITQTVVSATANDVVLALTREFAGIWSSESPDEHPNVVKERLQALRSEVSLDRLILVDPLGGIPASDRKNGYHVFLNMEQEYELAKQDLINRGGMHSVAPQKPTLPEASANFTVGDPILLSSFTENKPGELDDSPPPQNGSPAKHDPRMKFHLENLELVRSTLSLLPPSSSALITTPHEAANSEKQPEFKAAGVGTRRQRNPLIHNLLTDKPAFSSSLPVGRLGPMDKNEPISSSTKFAPTTFAKHGMPVTIFPDPKTTPWQPPIAGVPQISLTDPQIDLPRLVHLIEDSFNKKLDVQHYLRRVNNRIAGVIIAGEYEGGALLTWELPPGVPDGSEESRKRMVPYLDKFAVLKKSQGSGGVADVVFKSMVRDCFPGGDNPVNKWYFERSRATLKLSDTNWTMFFTTPEENMDHQTFKDYEAVCKFFGRENVGGYYQQGKRGIYVLDSE
What is the function of this protein?
N-acetylglutamate synthase involved in arginine biosynthesis.
What are the official names of this protein?
Amino-acid acetyltransferase, mitochondrial, Arginine-requiring protein 2, Glutamate N-acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UBP33_MOUSE
Sequence: MTTFRNHCPHLDSVGEITKEDLIQKSLGACQDCKVRGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTPPSLPHVRQPQQTQENSVQDFKIPSNPALKTPMVAVSEDLDIEVEEEDELKARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPANLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEMEEEPQTLTSEETVEEEKSQSDVDFQSCESCSSSEKAENESGSKGFPEDSNETTMLIQDEDDLEMAKDWQKEKVCNKINKANADVELDKDRDTVCETVDLNSQETVKVQIHGRASESITDVHLNDLATSQILPSNESVSPRLSASPPKLGSLWPGLSPPHKKAQSTSAKRKKQHKKYRSVISDIFDGTVISSVQCLTCDRVSITLETFQDLSLPIPGKEDLAKLHSSSHPTIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGIPPRKASYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIELEKIEKRRKTELEIFIRLNRAFQEEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGSVMLKQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDVLQAEEKIEVETRSL
What is the function of this protein?
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling.  Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate.  Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling.  Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1.  Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2).  Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2.  Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2.  This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins.  Deubiquitinates DIO2, thereby regulating thyroid hormone regulation.  Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 33, Deubiquitinating enzyme 33, Ubiquitin thioesterase 33, Ubiquitin-specific-processing protease 33, VHL-interacting deubiquitinating enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP20/USP33 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (By similarity).
Protein: BBRB_ORYSJ
Sequence: MDDDASMSIRWGGFFESPARNLGLQLMSSVPAERDTKQLLSGSPFLHHQHQQHVPHHHHQPHHPRDCGANGNANGGAMPPPPATEAPPSMPMNFARSDMWMHPQQQQQHHHPREHKALHNLTVGHGSSHIAHHDPVGYGMIPGTHTLQMMQQQTEPQLQPPPPPQQPKEECISSPLIEENVPVIDEPPPPKKRQQGRQPKVPRAKKPKKSAAPREDGAPPNAPAPRRRGPRKNIGMVINGIDLDLSRIPTPICSCTGAPQQCYRWGAGGWQSACCTTTISTYPLPMSTKRRGARIAGRKMSHGAFKKVLEKLAGEGYNLNNPIDLKTFWAKHGTNKFVTIR
What is the function of this protein?
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
What are the official names of this protein?
Barley B recombinant-like protein B, BBR-like protein B, GAGA-binding transcriptional activator BBR-B.
What is the protein family that this protein belongs to?
Belongs to the BBR/BPC family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PEPB_SHIB3
Sequence: MTEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKIDGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVEWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGEDLREQGYMGLHTVGRASERSPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPEMIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASASQENEPFWRLPLAEFHRSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHF11_RAT
Sequence: MAEETAPPCGPVSTGGSLSPEKMEKRTCALCPDGHEWSVIYFAPSANIAAHENCLLYSSGLVECGPHDPRNPARSFAVKSVKKEIWRGRRLKCSLCNKGGATVGCDLSSCRKSYHYVCAKKDHAIPQVDEDLGTYKIFCPEHPPQQEETTERADSPSVKKTGKKKSLSSGPPTEPKKMKFSRFKRLMKEEPHGHKDAAVKAPFLKKCLEAGLLTELFEQILEKMDSIHGRFMDETASESDYEGIKTLLFDCGLFGDILRKFQEVIKSKTCEYEERLNQMKQKLEALADLQENLCSFQECGDLDPSGSTSGSLLPPEDHQCRCQESPEVQAGSGDSL
What is the function of this protein?
Positive regulator of Th1-type cytokine gene expression.
What are the official names of this protein?
PHD finger protein 11.
What are the subcellular locations of this protein?
Nucleus.
Protein: THIP_BRUAB
Sequence: MTATPARRTSLASPATKPVAGGLALAFLATLAGGALLALALEAGGGGFDAAANFDTYLWRVARFTIWQAVASSLLSVLFAIPIARALYAEARFPGRGLILRLFALPLALPALVAVLGVTSIYGRNGLIAHISDMLGHPMQPDIYGIAGILIAHIFFNMPLAVRLLLAAYESIPDDHWKLAAQLGMGSRARFRLIEWPVIRRSLPGMIGLVFMLCVTSFTTVLTLGGGPRATTLEVAIYQSLHFDFDPARAVALTFTQLALTLLILLILRLTGRPSEEGFTQTATPRRYGSPRKTERLFNIIVIALGFLYVALPIAGVVVSGLTADLVRLLSERIVWHAIATSLALGFSAALLAVFLSLALVAAREATRNARIANIFDTGASLILVMPPIVIGAGWFILLRHFTDPFVMAPLMVVTVNAAMAMPFAVRLLRPAWDTAASRHNKLCSQLGIKGFNRLRLIDWPSIRRPCGMAFAFAMALSLGDLGTIALFGSDALVTLPYLLLQRMGSYRTFDAAGLALILGVLCLALMMIADRAAASRKEAFLQ
What is the function of this protein?
Part of the ABC transporter complex ThiBPQ involved in thiamine import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Thiamine transport system permease protein ThiP.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DRC11_HUMAN
Sequence: MSNAMYNKMWHQTQEALGALLDKEPQKMIEPQRNQVFIFQTLATFYVKYVQIFRNLENVYDQFVHPQKRILIRKVLDGVMGRILELKNEMVELELTEFHYFDDILQDLKLAPQQLDIPIPKYFLKEKLEVIKGREKILAQILADSGIDTSDMKYPVKSIPFDEAVKLIQIAERARQGRLRALFMKQIYLQEYRAKQSKMLGKKVTDTWAAALRIQKVWRRFHQRKETEKLREEEMIFLGMNPPPLFNEVSATVIQAEKVDRLRNEVQIKHEEDYREALVTIKNDLKLIEGVDIKENLQDQIRHWFIECRNLTGTFPDYPDVEEGGSAIIFSDKTIQQVIEDIIANQEEEEKNKKKKKKKEKQPKKAKKQKKGTKEKNKEEDEKWKMSPSLFLPAMKEGCNAYKEIWMKKDESWNFSQDYDPELIKEEKRKELQSEIRIQVDELMRQELKNLKLAVDRERERPVKAGKKKDKKGKKGKKKEKKAKKDKDLTADRTIESLYKELVEEGLLIQALKVNLSDYIGEYSYLGTTLRQVSIEPMPSLLDVRQLITLYGIWPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGLQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKKHLPQILKLLKPDDRILIVGTTRRPFDAELQSFCKVYQKIILVPRPDYASRYVLWKQIIERNGGVLTSALNVSCLAKVTDGFTQGHIVEVVKGVLTDQRIRRQIHKPLTAVEFITAITSMNPVYKEEEESFKNWYAKTPLGKKRALAITGGSTEKAKDKGKRK
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
What are the official names of this protein?
Dynein regulatory complex protein 11, IQ and AAA domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. DRC11 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: BACR_HALHM
Sequence: GIGTLLMLIGTFYFIARGWGVTDKKAREYYAITILVPGIASAAYLSMFFGIGLTTVEVAGMAEPLEIYYARYADWLFTTPLLLLDLALLANADRTTIGTLIGVDALMIVTGLIGALSHTPLARYTWWLFSTIAFLFVLYYLLTVLRSAAAELSEDVQTTFNTLTALVAVLWTAYPILWIIGTEGAGVVGLGVETLAFMVLDVTA
What is the function of this protein?
Light-driven proton pump.
What are the official names of this protein?
Bacteriorhodopsin, BR.
What is the protein family that this protein belongs to?
Belongs to the archaeal/bacterial/fungal opsin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y469_SYNWW
Sequence: MPQLPGETVSFKLERDDENKVRAILHTVYQALQEKGYNPINQLVGYMISGEPAYITSHSEARNLICKVDRDEIMEVLLKSYLQNSMGKGE
What are the official names of this protein?
UPF0297 protein Swol_0469.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: IF2_NATTJ
Sequence: MEKIRVYQLAKEIGLESKELVTTLQELDISVKNHMSTLSEEEADTVRELYTESSAKDEDNKDETSQQQDEKQEDKKEQGTTTDKPLVAPPITVGELAEQIGVESTSIITKLISKGVMANINQNLEEDSLEYLAQEFDFVVTQEEPEEDEKSEEDRIIEQIRSEEPKGEPLERAPVVTVMGHVDHGKTSILDSIRKTKSIEKEAGGITQHIGASRVLYNDKTVVFLDTPGHEAFTEMRARGAHVTDIAILVVAADDGVMPQTVEAINHAKSAGVPIIVAINKTDKPDANPDRVKQELTEYNLVTEEWGGDTICVSVSAVQNEGIDELLEMVQLVAEMNELTSYPQNTGKGTVIEAKLDKGRGPVATVLVEDGTLKVGDSVLCGSTFGNIRAMVDDRGKRLKQANPVTPVEILGLENIPEAGDEFQVVPDEKMAREIAKKKQEKEREEKLKRSQSVSLDNLFDQIKEGEQKELNIIVKGDVRGSVEALRESLLKLNDNEHEIKVNVIHAGVGTVSESDIMLAVASNAIIIGFNVRPDPNARKAAEREQIDMRVYRVIYEAIEDVKAAMAGLLDPEYKEVVQGQIEVRQLFKVSRIGTIAGCYVTDGYIRNNSYIRVIRDGRVIHEGNIKNLKRFQDDVKEVQQGYECGILLEKFNDLKEGDIFEAYTYEEISPDV
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ULAD_ECOHS
Sequence: MSLPMLQVALDNQTMDSAYETTRLIAEEVDIIEVGTILCVGEGVRAVRDLKALYPHKIVLADAKIADAGKILSRMCFEANADWVTVICCADINTAKGALDVAKEFNGDVQIELTGYWTWEQAQQWRDAGIQQVVYHRSRDAQAAGVAWGEADITAIKRLSDMGFKVTVTGGLALEDLPLFKGIPIHVFIAGRSIRDAASPVEAARQFKRSIAELWG
What is the function of this protein?
Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
3-keto-L-gulonate-6-phosphate decarboxylase UlaD, 3-dehydro-L-gulonate-6-phosphate decarboxylase, KGPDC, L-ascorbate utilization protein D.
What is the protein family that this protein belongs to?
Belongs to the HPS/KGPDC family. KGPDC subfamily.
Protein: RS19_STRPM
Sequence: MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSFIGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: BYST_DICDI
Sequence: MGKDVKKVHKLRHDPLSKQIEESESAYQKPHKRVGKLRKKKAEMENDTGIDETESVIPSALSKKILDQIREQAIEVEVEDRKKEKQEKLLTFEQERIQSKLLSFNDFIDDDDDDEDADQDDNKRRSNGNDFDENDGFEQFSDTESQFGVGGEVEIDEEDERVLSMFMGGGGGDGQEQQFQTRFTLGDIIESKLKEHESRQVSSENAINPKVIDVYTKVGKLLETYTSGKIPRAFRILPNFTNWEDLLYLTRPDKWTPHSIRVATKLFCMSTNSKITQRFLSIVVLPRVRDNIAEYKKLNYHLYMALKKSLYRPAAFYKAILLPLAESGDCTLLEAKIIGSVVCKVSIPVLHSSVALMKLSQLTRYNGATSMFIRMLCDKKYALPYRVIDGLVDHFVMFDEEVRELPVLWHRALLSFVQRYKTDITKDQKEKLKIILRKHNHHIITAEIRRELFFSNSRGGVAPSNFTDDTSSMME
What is the function of this protein?
Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
What are the official names of this protein?
Bystin.
What is the protein family that this protein belongs to?
Belongs to the bystin family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: XERD_SELRU
Sequence: MLLYILLIESRFIMKIKDNFMLIKNARIENNERLSLKAKRRLEKSKADNTLKAYACDWSDFSDWCQYHGVTDLPASPETIVNYINDLADDAKANTVSRRVTAISENHIAAGFSGRHNPAKDGMVRAAMSAIRREKGTFQRGKSPILMETLYLLADLFDEEKLSGLRDKALIYLGFAGAFRRSELVHIQYEDLTFTPQGVIIFMAHSKGDQLGHGEQIAIPYAPQAEICAVRALKKWLDTAQIHRGPIFRPITRVQSLRNTQLSDKSVALIVKKYVGLAGLDEHLFAGHSLRRGFATSAAQHDIDALTIMRQTRHKSEKMVHRYIEQGNIFKDNALNRMYNK
What are the official names of this protein?
Integrase/recombinase xerD homolog.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: MTND_SULSY
Sequence: MARLVFRKNGKVIENPEEIKSFLSQYGVVYDVWGVDRLPEDVRKNYDIDEENSKAIIQAYEKELKELKEKMGYITEDIVVLSEKTPNLDGLMAKFKREHHHIDDEVRFVVDGSGIFPVKIEDDIVDIHVEAGELIVVPAGARHWFELDENRKIKCIRVFKTPAGWEAIYNENETATMRD
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: CLXN_HUMAN
Sequence: MNRKKLQKLTDTLTKNCKHFNKFEVNCLIKLFYDLVGGVERQGLVVGLDRNAFRNILHVTFGMTDDMIMDRVFRGFDKDNDGCVNVLEWIHGLSLFLRGSLEEKMKYCFEVFDLNGDGFISKEEMFHMLKNSLLKQPSEEDPDEGIKDLVEITLKKMDHDHDGKLSFADYELAVREETLLLEAFGPCLPDPKSQMEFEAQVFKDPNEFNDM
What is the function of this protein?
Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule.  Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity).  Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality (By similarity).
What are the official names of this protein?
Calaxin, EF-hand calcium-binding domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: MSH3_DICDI
Sequence: MPRLKLPKSFKDELESEKTTTTSSRKKAPVVDPKQTLMSSFFTPVSKSTDTKEINNKEDKDEDKDKDKDNKKTKKSKDTSDNEDMVDDNNKQQKEKKATPNKSNSPQSPQTSKSPLTRRSSANGNSDSKIDNKEKEKEKEKEKEKDKSTPTKTTSSRVKKDTEVSKSIPPKLSKQTKKKQISSDNDIYDDEKDSEEEDLEDDHDDEEEKVVVKKPSKPTSKSITAKPASTKATTTTTTTTTTTSTGRTRVNRVNLDISFSSESEEDEKPKKKIIGKKRKKKDDSDFDSESESDTISEASEVEPESEEDLDSFKFNSKKKNNNKNNNNKKKNDEYEDEEEDEDDELFKDIEMKDKPEEEEKEEEGDPIVIGSGRVVLPKGTPDFQPDPKAGKKLLKAHLEIQSKEEAKRLQQANGGGGDGGGGQIKGSDDEDEEVKKPTKGGSKASAKKKGPAYTPLEQQYIAIKKENPDTVLMVECGYKYKFFGEDAEVANKVLNIYSYVAKNFLNCSIPTQRLFFHLRRLVMAGYKVGIVEQTETAALKAISSSKSQPFERKLTRVYTSSTFIDDDIDDQLTSSSPQFLVSFYESTPKNKNDDVIKKQRDNEEEGIDSSNESSTSTISFVAVSVKTGEIIYDTFKDNVMRSQLETILTHIKPSEILIPPTTTTVNKQKVNNGIGTNHYYFSNLTSKCLKTYTKSTNVRTQAMDSQLYDYEYSLGKLIDFYEDESNNNNNNNNCEDVLKFVKSTLNKEQIICLGILLSYLNEFIHFGSILKVESNFKAFRVSNHLVLPHSTIVNLELLVNESDNKEKGSLIWLMNRTSTFSGSRMFINWICKPLNQLELIKERQDAVEELVNGIKTNSPPIVSIISLFKSHIPDLQRNLSRIYYKVQCTPKEFLNTMTSLQRIVELFKEINNNNSSYKFNSTLLNSIFKLQNDNKDGDSDSFDYIGGEDKLSKRIKYFLSNINKETAKEYGTVGCDKSNLWVDLEKYEKIRETKEKIEQVEKEFKNVLKNIRKELSKPSLEYHHMPGLGLEYLLELPPSFKAVPKSWIKVNSTQKMARYHAPEVLEQLKILSQSRETLKIQSQESWISFLGEFSVDYSLFSNFVNKISNLDCLFSLAKVSSLEGYIRPQFVKEKKDGGIQIENGRHPVVEAILSGSDGSYVPNTIELRESACKSMIITGPNMGGKSSLLRQTALIVIMAQVGCFVPATSCSLSVFDAIYTRMGARDSIGTGKSTFFIELEETSDILKNSTQNTLVILDELGRGTSTNDGVAIAYSTLKYIVEVMKCYCLFVTHYPLLAQLELQYPTQVGNFHMGYLEEKQDQQLQKSVIPKVIFLYKLVKGAAQNSYGLNIARLAGLPMEVIADALKKSNEMKESITRRANLSDGKDQQQIENEIKSIIKNWNSNRTTLNSNDLLQFIEKFKSIQLKL
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis (By similarity).
What are the official names of this protein?
DNA mismatch repair protein Msh3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
Protein: PURA_YEAS2
Sequence: MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELETLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRELELSGRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPGAWEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKEIK
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2225_STAHJ
Sequence: MGRKWNNIKEKKAQKDKNTSRIYAKFGKEIYVAAKSGEPDPESNQALRLVLERAKTYSVPNHIIDRAIDKAKGAGDENYDHLRYEGFGPSGSMLIVDALTNNVNRTASDVRAAFGKNGGNMGVSGSVAYMFDHTATFGIEGKSADDILEALMEQDVDVRDVIEDGDLTIVYAEPDQFAHVQDALRQTGVEEFKVAEFEMLPQTDIELSEDDQATFEKLIDALEDLEDVQNVFHNVDLK
What are the official names of this protein?
Probable transcriptional regulatory protein SH2225.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSIO_DICDI
Sequence: MKEKIKLSLLILTSIILAVANSQTQPKTLAMTATVYDQHTFYNDNFENQGPAYLTKNMVVSKLDKTLKIPQLVSLDINVEGKTGVNYFGTMYNPKLFKYFFSENTNASPDDKNSGKNFPLLMDLILTLNETSGAYEFSKQEYFPINGKGFNDPSYKVPPKYKADSPNVDWFKMAGGGYSQNNYNYCIKLNSKFTYFNKGEVFNFRGDDDVWVFIDNRLVVDLGGLHTAETANIKLKDITNPPLQTNKIYDLDFFYCERRATGSSIQLSTTLEIFCVDDYCGVCNGDGTSCCTSSTCEDNNACTIDKCPKLGSVAPGKFTKDDCVYSEVVCPIESNQCLRPYCDPKEGCKTSPVECVNGNIDKCFEQFGSCDSSLGCQYNYKCNAYGKCNLGCSGGQCKVKTSEQCSEEFGNDPCYTYSCDVELGCVRTEKCSQEDAKLCTINTCLKNVTREDDRCELVSIQEECNCCAGHTVDPCQLPGCGEPGECKPVDKIIDDNNLCTIDKCENGTITHTPVKCGGCSICDSKTGQCVINPPICDDDNVCTIDTCSLVENPNGSIDGVCSNKIFDCASNDTDLCNIWTCDANNGGCQSIKKVCDDPSPCLVSKCEPSTGQCVDSPRTCDHGGAFCLISECDERLGCIVYNRQCASDNRKCQAGVCVNGTSSEEGHCTSVDYDPLPFGCNTAAVVSTAVIAGVTVAAVVGLGIFLYGGKKGYDYYQDNKSKGMTGANSNPLYKESGNAGQNPLYNDNNL
What are the official names of this protein?
Protein psiO.
What is the protein family that this protein belongs to?
Belongs to the prespore-cell-inducing factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PTH_LIMRJ
Sequence: MKMIVGLGNIGTRYDETRHNTGFMVVDQLARDYHLGAFTHLKQEAVAVSGVINGEKVMLVKPTTFMNDSGRAVGPLVDYYDIDLDDLVIVNDDLDMPVGKVRLKTHGASGGHNGLKSIISVLGTKNFNRVKVGIDHPQHGTVVSHVLGKFSKEERPKFDQAVEQAEHALEDWINGEDFAKLMNAYN
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTM1_KLULA
Sequence: MSTDKTQVKLRFFTREEDETLHVNDAPIYAPVSLKRYGLSEIVNHLLELPKSMPFDFLIDGELLRTSLQDYLIKKGLSSETFLNVEYTRAVLPPSYLSSFDNEDWVSSLDVGSNYIYSGSYDGIVRTYNLSGKVEKQYSGHSGPIRAVHYISSTRLVSAGNDRTLRLWKTKNDDLKSIDEEEIEDGKTLAILEGHKAPVVSIDVSKDRILSASCDNTVSLWSTNYKEMTVIDPMEDLGGNVSTAAKKRRKLTLKDGSIRRRAPLALFESHSAPVEAVIFDKSDDTVGYSVSQDHTIKTWDLITAKCVDTKTTSYSLLSVAQLPKLNLLACGSSARHITLHDPRVNSSSKITQQQLVGHKNFVVALDTCPENEYMICSASHDGTVKVWDVRSNTAMYTITREDKNVVKGVNDKVFAVKWAKGVGIISGGQDKKIQINKGDNIFSN
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein YTM1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR12/YTM1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: OMP2_CHLMU
Sequence: MSSKLVNSLRLTFLSFLGIVSTSLDAMPAGNPAFPVIPGINVEQKSACAFDLCNSYDVLSALSGNLKLCFCGDYIFSEEAQVKDVPVVTSVTTSGVGPSPTITSTTKNRNFDLVDCSLSANCVAAAFSLPDRTMSAIPLFDASFEVKIGGLKQYYRLPMNAYRDFTSDPLNSESEVTDGLIEVQSNYGFVWDVSLKKVLWKDGVSFVGVGVDYRHASCPIDYIIANSQANPEVFIADSDGKLSLKEWSVCLGLTTYVNDYILPYVAFSVGNVSREAPDNSFKKLEERFTNLKFKVRKITSSHRGNICIGATNYIADNFFYNVEGRWGSQRAVNISGGFQF
What are the official names of this protein?
Outer membrane protein B.
What is the protein family that this protein belongs to?
Belongs to the chlamydial OMP family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: CSN2_MOUSE
Sequence: MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
What is the function of this protein?
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.  Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
What are the official names of this protein?
COP9 signalosome complex subunit 2, SGN2, Signalosome subunit 2, Alien homolog, JAB1-containing signalosome subunit 2, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP-15.
What is the protein family that this protein belongs to?
Belongs to the CSN2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.