PharMolix/UniProtQA huggingface dataset:
Protein: AGE1_CAEBR
Sequence: MSMGRSSSTTFRNRTASHGSRSLGSAETARIPRKLSSQLSHTHANILHPQLQTMMEQWQMRERPSLETENGKGSLLLSSEGVADMIVLSSFGEVISVVFPWFLANVRTSFDIKLSEFKHQLFEQIGPMKWGKHSTQPQDYAFRQLNNFGEIEVIFNDDQQLSCLELHGTFPMLFLFEPDGFNRDKELMCDISHCLGYSLDKLEESIDEELRQFRASLWTQTKKTCFERGVDGVDHYAFPEEQYFCVGEKCPTDLESKVKAAKLDYQLFWTKRKSEANEVWEKMYKITIDFDPEFNPQSLMRMFVKELQCMNLFDPEDPPDEEWILQLAGRTSFVTRPEISLVSYDGIRSELESYRCPGFVVRRKSLVLKDYVRPKPLYEPHYVRVHERKMALDVLSVSIGTEVKHSGNSDKVWTDFRPTASLEQITLWDLDSNLMIRPVNVTGLPFTASHDIYLGMEFKVYVGTLTLATIKIPRVPTTKLVWKREFFTFDLYMKDMPPSAILSVRVYSMKTTKMKEEIELGWVNISLSDWRDELRQGQIKLNLWGPEPSANRSRIGHNGAKIGTSLSVTVEISSHGRRVKMPNEAQYKYLVDHRISWSDTVEIVGDDYEACIGDPGYKKLQDLVKKHESGVILDDSEQRHVWSWRNYIQKQEPDLLVVLSELRIVWTDRENFSELYVMLETWKAPSVAAALTLLGKRCTDRVIRKFAVNKLNDQLSQFNVHLFLLPLIQALKYEPRAYSEVGMMLLTRALSSYRIGHRLFWLLRSEICRLKDCATNNEEYRRISLLMEAYLRGNEEHIKGIIRQVDMVDELTRISSLVKGLSKEAAREKLRDQLRTISHKMESIDSPLDPVYKFGEMVIEKAIVLGSAKQPLRLVWKNKNPKSDLHLPFCEVIFKNGDDLRQDMLVLQVLEVMDTIWKAANIDCCLSPYGVLPMGEMIGIIEVVPNCKTIFEIQHKAGLVNTAARSVDSNFMNKWIRKQCGFVDEKKKYKKGGGPTVDSAQATKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEQFLTIIRSGKPVDGNSHEIQKFKTLCLEAYEVMWNNLKYKFQKTLCCKGETKEKARKFFAGVYEEAFNGSWSTKTNWLFHAMKHY
What is the function of this protein?
Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause.  Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3.  Could function in the development or neuroendocrine signaling of the dauer pathway.  Mediates susceptibility to enteropathogenic E. coli infection.  May negatively regulate AYI interneuron neurite outgrowth.  Plays a role in aversive olfactory learning when an odor is associated with food deprivation.  Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning.
What are the official names of this protein?
Phosphatidylinositol 3-kinase age-1, PI3-kinase age-1, PI3K age-1, PtdIns-3-kinase age-1, Aging alteration protein 1.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
Protein: SL9B2_MOUSE
Sequence: MEDEDKTAECQHSKPPTGITHEAPPHHELQEERVMSLRGTDRSEPTEGSNLLTSGEKKPQDSPTEPNGLQSLRRFLACPPRGCLARVITNGTMVVLLWAMVWSVTGPECLPGGNLFGIIILFYCSITGGKLFGLIKFPTLPPLPPLLGMLLAGFLLRNIPVINDSVRIQHKWSSSLRSIALSVILVRAGLGLDSKALRKLKGVCVRLAMGPCIVEACASAILSHFLMGLPWQWGFILGFVVGAVSPAVVVPSMLLLQEGGYGVGKGIPTLLMAAGSFDDILAITGFNTCLGVAFSTGSTVFNIFRGILEVVIGVAAGSFLGFFIQYFPSRDQDNLVWKRAFLVLGFAVLAVFSSVYFSFPGSGGLCTLVMAFLAGMRWTDKKSEVEKVIAVTWDVFQPLLFGLIGAEVSIVSLRAETVGLCVATLSIAVLIRILTTFLMVCFAGFNIKEKIFISFAWLPKATVQAAIGSVALDTARSHGEKQLEDYGMDVLTVAFLAILITAPIGSLLIGLLGPRVLQKSEHRTEEEVQGETSAHIQRKPEDSITEA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18508966, PubMed:17988971).  Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume.  Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (PubMed:23720317).  Involved in sperm motility and fertility (PubMed:27010853).  It is controversial whether SLC9B2 plays a role in osteoclast differentiation (PubMed:17988971) or not (PubMed:20441802, PubMed:22985540).
What are the official names of this protein?
Sodium/hydrogen exchanger 9B2, NHA-oc, Na(+)/H(+) exchanger NHA2, Na(+)/H(+) exchanger-like domain-containing protein 2, NHE domain-containing protein 2, Soditlum/hydrogen exchanger-like domain-containing protein 2, Solute carrier family 9 subfamily B member 2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Strong colocalization with LAMP1 and TCIRG1 in osteoclasts (PubMed:20441802). In beta-cells colocalizes with RAB4A and SYP (PubMed:23720317). Localizes to the basolateral membrane of polarized osteoclasts (PubMed:20441802). On the contrary to (PubMed:17988971) not detected at the mitochondrion membrane (PubMed:20441802, PubMed:23720317).
Protein: DF253_ARATH
Sequence: MRFASLFVVYCTFMFLDISHVKCEVEPVPYCKVITWYDVKCGADGNKTCVDHLIKGHIYDVPVCDCSELTTSGILCTCQHRFPCKEPPPLHRISIRKQIRG
What are the official names of this protein?
Putative defensin-like protein 253, Putative S locus cysteine-rich-like protein 15, Protein SCRL15, SCR-like protein 15.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: NFI_SULIY
Sequence: MVEKHLLEFLEKLQFLISKNVKISHYGIENVKKICGVDIAYKGNLGFSVGVSMDINSGDYNYKSYVGEVNFPYIPGFLFMREAPLMIKAIEGLDCHLLLVDGHGIAHPRKSGIAAVIGVLLDFPTIGVAKSRLTGDLVNESEITYVYLNGEKVGVKFGRYFYSPGNKVDLQDCIELGKRGYPKVLKIADMLTKKIKKE
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYG_SAPAP
Sequence: MGLSDGEWQLVLNVWGKVEADIPSHGQEVLISLFKGHPETLEKFDKFKHLKSEDEMKASEELKKHGATVLTALGGILKKKGQHEAELKPLAQSHATKHKIPVKYLEFISDAIVHVLQKKHPGDFGADAQGAMKKALELFRNDMAAKYKELGFQG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ATP62_SYNC1
Sequence: MTHPFVLLKWLIAKLHFGFSAEMLEQHGFFQHVTHTWLVMAILIGVGLLATHRAGLVPGGMQNFMELVLVEIRGMVRDTMGPKGMVYFPLIATLALFLLVSNLIGLIPGFAPPTASLNTNAALAVGVFLVTHIVGVREHGIRYFKHFMGPVWWLTPLILPIELIGHLARPLSLSLRLFGNMYGHEIVLMIFFSLVPLLLPIPMMLMGILVAFIQTFVFMLLSMIYIAGALEEAH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a 2, ATP synthase F0 sector subunit a 2, F-ATPase subunit 6 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SLYX_BRUC2
Sequence: MSAEERLIELEIRVAEQEKTIDELSSVLTEQWKTVDQLSKKLNALTNRFLELEEQAAPDVPVTKPPHW
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: RL30_STRPS
Sequence: MAQIKITLTKSPIGRIPSQRKTVVALGLGKLNSFVIKEDNAAIRGMITAVSHLVTVEEVN
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: DAPF_THISH
Sequence: MRIQFSKMHGLGNDFVVIDAIHQPVDLSPDQVRLLAHRRFGVGCDQVLLVERPSDPAAADFRYRIFNADGNEVEQCGNGARCFAVFVRERGLTAKDHIPVETAAGIIHLQVQPDGQVTVDMGPPRLKPWQIPFEAESAMTSYPLEVEGETYEIGAVSMGNPHAVLRVDNVQTAPVARLGPLIEAHPRFPRHVNVGFMQVVSPGEIRLRVYERGVGETLACGTGACAAVVSGRIQGLLDETVAVDLPGGRLVINWAGQEEAPVMMTGPATQVFTGSIDI
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAB_MYCPN
Sequence: MVSNKLEQTFKFANDKNIERAERVLMQALVQDAVGVDLILTKLEPKDFFGFPFNFIFQTAQENYSEGNKLFGSALLEAVKFKLDTDSKTQREIEGLFEDVLLKGLPFLERDIKVFVDVVKKASIFRQLKQFAKKVEKEEFKVKDDRFEGYLQAIQNDFTKIIHSAFVSIPGLSYDEIVREEEELIPKVYRGELTVKGLKSGFYPLDQLTSGWKEGELIVVAARPGRGKTALLINFLQGAVNDSEKFDKNKDVLLFFSLEMRNREIYQRHLMLESQVNYTLTSRQRLANVYDDLIKASEVLRDLPIKIFDYSTITLDEIRAQITEVSKTNNVKLVVIDYLQLVNAFKNSYNISRQQEVTMISKSLKSFAKEFNVPIIAAAQLSRRIEERKDSRPILSDLRESGSIEQDADMVLFIHRVKDEDSENQEAIGHNNIFQVELILEKNRSGPTGKVQFDFQSDVSTFRVREYNPDGYS
What is the function of this protein?
Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.
What are the official names of this protein?
Replicative DNA helicase.
What is the protein family that this protein belongs to?
Belongs to the helicase family. DnaB subfamily.
Protein: Y1430_MYCTA
Sequence: MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFMEASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLRDSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMGLLRSDQQLSVRALHRDLGRE
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein MRA_1430.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: RL32_XANOM
Sequence: MAVQKSRVTPSRRGQRRSHDALTAKQLSTDPTSGEIHLRHHITADGYYRGKKVITTKSSAVQED
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: MINE_DESAP
Sequence: MDFLARLLGRESPGSKNVAKERLRLVLIHDRADISPQLLQLLKNEIVEVISKYMEIDDKGLEVSLEHVDKQVALVANIPIRKMKRAANI
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RMD2_MOUSE
Sequence: MPHSTNKELILGIMAGTAGISLLAFWYHKVLKPRTTMNFPKLLSLGKKFGSLTLPEESHSAQGASVVFQRRQLQILEKLNELLTNMEELKEEIRFLKETIPKLEECIQDEFGGKVTVHKISPQHRARKKKGTTVQRSATSNSSEEAESEGGYITANTDTEEQNFPFPKALNTHIEELKLDVLLQKADHLRTNESHKMESFELLCDHKEKFSEETEFLWRLARAYGDMYDLSTSTQEKKHYANIGKTLGERAITRAPMNGHCHLWYAVLCGYVSEFEGLQNKINCGHLFKKHLEIAIQLLPEEPLLYYLKGRYCYTVSRLSWIEKKMAATLFGEIPYSTVHEALHNFLKTEELQPGYSMSNYMYTAKCYVELGEPQEACKFCNLALLLPVVTKEDKDAHKEVKKMISSLKR
What are the official names of this protein?
Regulator of microtubule dynamics protein 2, RMD-2, mRMD-2, Protein FAM82A1.
What is the protein family that this protein belongs to?
Belongs to the RMDN family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region (By similarity).
Protein: Y463_NEIG2
Sequence: MKIVLISGLSGSGKSVALRQMEDLGYFCVDNLPLEMLPSLVSYHIERADETELAVSVDVRSGIDIAQAREQIAYLRGLGHRVEVLFVEAEEAVLVRRFSETRRGHPLSNQDMTLLESLKKEREWLFPLKEIAYCIDTSKMNAQQLRHAVRQWLKVERTGLLVVLESFGFKYGVPNNADFMFDMRSLPNPYYDPELRPYTGMDKPVWDYLDGQPLAQEMVDGIERFVTRWLPRLEDESRSYVTVAIGCTGGQHRSVYIVEKLARRLKGRYELLIRHRQAQNLSGR
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein NGK_0463.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: SUB2_SCHPO
Sequence: MASAQEDLIDYEEEEELVQDQPAQEITPAADTAENGEKSDKKGSYVGIHSTGFRDFLLKPELLRAITDSGFEHPSEVQQVCIPQSILGTDVLCQAKSGMGKTAVFVLSTLQQIEPVDGEVSVLVLCHTRELAFQIKNEYARFSKYLPDVRTAVFYGGINIKQDMEAFKDKSKSPHIVVATPGRLNALVREKILKVNSVKHFVLDECDKLLESVDMRRDIQEVFRATPPQKQVMMFSATLSNEIRPICKKFMQNPLEIYVDDETKLTLHGLQQHYVKLEEKAKNRKINDLLDSLEFNQVVIFVKSVSRANELDRLLRECNFPSICIHGGLPQEERIKRYKAFKDFDKRICVATDVFGRGIDIERVNIVINYDMPDSPDSYLHRVGRAGRFGTKGLAITFSSSEEDSQILDKIQERFEVNITELPDEIDVGSYMNA
What is the function of this protein?
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus.  SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly.  May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.  Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC).
What are the official names of this protein?
ATP-dependent RNA helicase uap56.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PLSX_BURMA
Sequence: MTVKLTIDCMGGDHGPSVTVPAAVKFVRSHPDAHLMLVGIESAIRAQLKKCKALGEPALSVVPATEVVAMDDPVEVALRKKKDSSMRVALNHVKEGAAQACISAGNTGALMAVSRYVLKTLPGIERPAIAFALPNPTGYTMMLDLGANVDCEPQHLLQFAEMGHALVAALEGKERPTIGLLNIGEEVIKGNETIKRAGELLRASTLNFRGNVEGNDIYKGTVDVIVCDGFVGNVALKTSEGLAQMLADIIKEEFSRSLLSKLMAILALPVLLRFKKRVDHRQYNGAALLGLRSLVIKSHGSADAYAFEWAIKRGYDAVKNGVLERLSRAMAENAAPLGESGRDANGAGQASPSAGQPAEPSAALSSKT
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: CBPYA_AJEDR
Sequence: MKSLALALLVGGAIAAGPQQQVLQAPVDNPDVAEPPLQTIADTFDHLRGQATNLWNDVIDKVPNIMDTITHTPPPKKFNRRPDSEWNHIVRGAEIQAVWVEGDDGEKHRKVGGKLEAYDLRVKAVDPKSLGVDTVRQYSGYLDDNENDKHLFYWFFESRNDPENDPVVLWLNGGPGCSSLTGLFLELGPSSITEDLKVNYNPYSWNANASVIFLDQPVNVGYSYSGGSVSDTNAAGKDVYALLTLFFEQFPEYAKQDFHIAGESYAGHYIPVFASEIMAHKERNINLKSILIGNGLTDPLTQYPLYRPMACGEGGYPAVLDQASCQSMDNALPRCLSMIEACYSSESAWTCVPASIYCNNAIIGPYQRTGRNPYDVRTDCEGGNLCYTQLGDISKYLNQAEVMKALGAEVSTYDSCNMDINRNFLFRGDWMKPFHRLVPGLIAEMPVLLYAGDADFICNWLGNKAWAEALEYPGHAKFAAAEMKNLTIVDNKSKGKVIGQVKSAGNFTFMRLYGGGHMVPLDQPEASLEFMNRWLKGEWSAKSSS
What is the function of this protein?
Vacuolar carboxypeptidase involved in degradation of small peptides.  Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).
What are the official names of this protein?
Carboxypeptidase Y homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: ILVB_ARTPT
Sequence: MQDQKQAVKRVTGAFALIDSLRRHGVQHIFGYPGGSNLPIYDEIYRAEQAGEIKHYLVRHEQGAAHAADGYARSTGKVGVCLATSGPGATNLVTGLATAYLDSVPVLAITGQVPRSALGTDAFQEIDIFGITLPIVKHSYLVREPSELPRIVVEAFHLAMSGRPGPVLIDIPKDVGNAQIDYIPVEPGSVRRVGYRPTERGNPRQINQALQLISEATKPLLYVGGGAIMAGAHAEIAELSERFQIPVTSTLMGKGRFDENHPLSLGIVGMLGMHGTAYANFAVMELDFVIAVGVRFDDRVAGTGDQFAHSAKVIHIDIDPAEVGKNRSTDVPIVGDVRQVLGDMLQRTYHWERKLSRNKPRNGTDLNQLREPIPLTVPHPEDGISPQDGDWELSHQCPDAFYTTDVGQHQMWAGQFVQNGPRRWMTSGGLGTMGYGLPAAVGVKVAHPHDTVTCISGDGSFQMNMQELGTIAQYGIGVKVIILNNGWLGMVRQWQHMFYNDRYEATNLEDGTPEFARLADVYGLEAMNVRQRKIYQRRLPKALSHKGPMILDVRVTRDEDCYPMVAPGHDNSDMMGLSS
What are the official names of this protein?
Acetolactate synthase, ALS, Acetohydroxy-acid synthase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: YCF4_TRIV2
Sequence: MTASTTINKGDSPNGDSSASSVLHQKVLGSRRFSNYWWASIVTLGASGFLLAGISSYLKVNLLIVTDPTQLIFVPQGLVMGLYGTAGLLLASYLWLAILWDLGGGYNDFNRETGNIKIFRWGFPGKNRKIEIGSRIQDIQSVRIDIKEGLNPRRALYLRVKGRRDIPLTRVGQPLSLAELETQGAQLARFLGVPLEGL
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: TOX_MOUSE
Sequence: MDVRFYPPPAQPAAAPAAPCLGPSPCLDPYYCNKFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQTMDLPEITVSNMLGQDGALLSNSISVMQEIGNAEGAQYSSHPQMAAMRPRGQPTDIRQQASMMQPGQLTTINQSQLSAQLGLNMGGTNVAHNSPSPPGSKSATPSPSSSVHEDECEDASKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYTDPVDVKTSQPPQLVNSKPSVFHGPSQAHSALYLSSHYHQQPGMTPQLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLSMQQHQSLAMQQPLGSQLPMQVQTALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWSTDYCSSGGMQRDKALYLT
What is the function of this protein?
Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (PubMed:25527292, PubMed:20818394, PubMed:11850626, PubMed:18195075, PubMed:15078895, PubMed:25915732).  Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA (PubMed:25527292, PubMed:31207603, PubMed:31207604).  During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors.  Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate.  May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (PubMed:25527292).  Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches (PubMed:20818394).  Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment (PubMed:11850626, PubMed:18195075).  Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells (PubMed:18195075, PubMed:15078895).  Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC).  May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage (PubMed:25915732).  Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:20818394).  Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming.  May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (PubMed:31207603, PubMed:31207604).
What are the official names of this protein?
Thymocyte selection-associated high mobility group box protein TOX, Thymus high mobility group box protein TOX.
What is the protein family that this protein belongs to?
Belongs to the high motility group (HMG) box superfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACEK_ALBFT
Sequence: MFPTRLDSSLAYDIAKAMMDGFNRHYRLFRTESARAKHRFETADWHGQQRAQRDRIEFYDLRVRECFMRLAREFKADEQPMEVWQQVKLHYIGLLVDHHQPELAETFFNSVTTKILHHSYFQNDFIFVRPAVSTEYIENDESETSPTYRSYYPTHDSLAEVLVQMVLDFDLRCPFADLDSDAARVQAAMVEQLGEVKLRANFQLQVLSGLFFRNKGCYIVGKLINGFNEFPFALPVLYGRAGQLVIDAVLFGEDDLLMLFSFARAYFMVDMEIPSAYVQYLRSMMPRKPRNEIYNALGLAKQGKTLFYRDFLHHQRHSTDKFRIAPGIKGMVMLVFDLPSFPYVFKVIKDFYPPPKDTTREQIKAKYLLVKQHDRVGRMADTLEYSEVGFPRARFDDELIAELEKFAPSQLEISDRDGDGRIEVIIKHVYIERRMIPLNIYLQEAFDAGGANPDDTSPAALRAREQIERGVIEYGNALKDLVAANIFPGDMLWKNFGITRHGKVVFYDYDEIEYITDCNFRKVPQARNEEDEMSGEVWYRVGPKDVFPETFAPFLLGNPFVREVFMKHHAELLDAAFWQSHKERIQAGHVYDVFPYDQGKRFHPEISDAQVPSSI
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHA_RICCN
Sequence: MTKAYNIIHHKFDVVVVGAGGAGLRSAFGMAKEGLNTACITKLFPTRSHTVAAQGGISAALGNMGEDDWRWHMYDTVKGSDWLGDQDAIEYMCKNAPDAILELEHYGVPFSRTEEGKIYQRPFGGMTTEYGKGKAAQRTCAAADRTGHAILHTLYQQSLKHKVQFFVEYFAIDLLMEDGECRGVVAWNLDDGSLHCFRAHNVVLATGGYGRAYFSATSAHTCTGDGGGMAIRAGLPLQDMEFVQFHPTGIYSAGCLITEGARGEGGYLVNANGERFMERYAPAAKDLASRDVVSRAMTIEIREGRGVGEHKDHVFLHLNHLSPEILHSRLPGISETAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNYHGQVIIKDGKNHNSVVKGLMAIGEAACVSVHGANRLGSNSLLDLVVFGRSSALKAAELIKPASPHRSIKEESLEKIINRFDKVRHANGNILVAELRLKMQRTMQSHASVFRTQEVLDEGAGMISEIRSGYKDIKINDKSLIWNSDLVEALELDNLLDQALVTVYSAAARKESRGAHAREDYPDRNDEDWMKHTLSSIDEAGKVVLDYKPVTLTTLTDEVTAVPPVKRVY
What are the official names of this protein?
Succinate dehydrogenase flavoprotein subunit.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRC_PYRAB
Sequence: MELVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYELISKYPERPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVKEGDD
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.