PharMolix/UniProtQA huggingface dataset:
Protein: HDG11_ARATH
Sequence: MSFVVGVGGSGSGSGGDGGGSHHHDGSETDRKKKRYHRHTAQQIQRLESSFKECPHPDEKQRNQLSRELGLAPRQIKFWFQNRRTQLKAQHERADNSALKAENDKIRCENIAIREALKHAICPNCGGPPVSEDPYFDEQKLRIENAHLREELERMSTIASKYMGRPISQLSTLHPMHISPLDLSMTSLTGCGPFGHGPSLDFDLLPGSSMAVGPNNNLQSQPNLAISDMDKPIMTGIALTAMEELLRLLQTNEPLWTRTDGCRDILNLGSYENVFPRSSNRGKNQNFRVEASRSSGIVFMNAMALVDMFMDCVKWTELFPSIIAASKTLAVISSGMGGTHEGALHLLYEEMEVLSPLVATREFCELRYCQQTEQGSWIVVNVSYDLPQFVSHSQSYRFPSGCLIQDMPNGYSKVTWVEHIETEEKELVHELYREIIHRGIAFGADRWVTTLQRMCERFASLSVPASSSRDLGGVILSPEGKRSMMRLAQRMISNYCLSVSRSNNTRSTVVSELNEVGIRVTAHKSPEPNGTVLCAATTFWLPNSPQNVFNFLKDERTRPQWDVLSNGNAVQEVAHISNGSHPGNCISVLRGSNATHSNNMLILQESSTDSSGAFVVYSPVDLAALNIAMSGEDPSYIPLLSSGFTISPDGNGSNSEQGGASTSSGRASASGSLITVGFQIMVSNLPTAKLNMESVETVNNLIGTTVHQIKTALSGPTASTTA
What is the function of this protein?
Transcription factor which acts as positive regulator of drought stress tolerance.  Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323).  Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters.  These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957).  Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters.  These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924).  Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485).  Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885).  Seems to promote cell differentiation (PubMed:25564655).  May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655).
What are the official names of this protein?
Homeobox-leucine zipper protein HDG11, HD-ZIP protein HDG11, Homeodomain GLABRA 2-like protein 11, Homeodomain transcription factor HDG11, Protein ENHANCED DROUGHT TOLERANCE 1, Protein HOMEODOMAIN GLABROUS 11.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class IV subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YTX2_XENLA
Sequence: MALSISTLNTNGCRNPFRMFQVLSFLRQGGYSVSFLQETHTTPELEASWNLEWKGRVFFNHLTWTSCGVVTLFSDSFQPEVLSATSVIPGRLLHLRVRESGRTYNLMNVYAPTTGPERARFFESLSAYMETIDSDEALIIGGDFNYTLDARDRNVPKKRDSSESVLRELIAHFSLVDVWREQNPETVAFTYVRVRDGHVSQSRIDRIYISSHLMSRAQSSTIRLAPFSDHNCVSLRMSIAPSLPKAAYWHFNNSLLEDEGFAKSVRDTWRGWRAFQDEFATLNQWWDVGKVHLKLLCQEYTKSVSGQRNAEIEALNGEVLDLEQRLSGSEDQALQCEYLERKEALRNMEQRQARGAFVRSRMQLLCDMDRGSRFFYALEKKKGNRKQITCLFAEDGTPLEDPEAIRDRARSFYQNLFSPDPISPDACEELWDGLPVVSERRKERLETPITLDELSQALRLMPHNKSPGLDGLTIEFFQFFWDTLGPDFHRVLTEAFKKGELPLSCRRAVLSLLPKKGDLRLIKNWRPVSLLSTDYKIVAKAISLRLKSVLAEVIHPDQSYTVPGRTIFDNVFLIRDLLHFARRTGLSLAFLSLDQEKAFDRVDHQYLIGTLQAYSFGPQFVGYLKTMYASAECLVKINWSLTAPLAFGRGVRQGCPLSGQLYSLAIEPFLCLLRKRLTGLVLKEPDMRVVLSAYADDVILVAQDLVDLERAQECQEVYAAASSARINWSKSSGLLEGSLKVDFLPPAFRDISWESKIIKYLGVYLSAEEYPVSQNFIELEECVLTRLGKWKGFAKVLSMRGRALVINQLVASQIWYRLICLSPTQEFIAKIQRRLLDFLWIGKHWVSAGVSSLPLKEGGQGVVCIRSQVHTFRLQQIQRYLYADPSPQWCTLASSFYRQVRNMGYDRQLFIIEPEGFLRNLSTLPAYYQDTLKTWSMVSVLRQGATEGEDILNEPLLYNPSFKTRMLESISIRRRLCQAQLTRVGDLLDFEKSDWVDSQAVMQRMGFLTTRVPHRLLKEIKDTISPDSHTFIDGVLHAGEPRPPWNSSPPDIIIAPKTRQSPQAPPSPNLSQLENFPLTRFHDITRKLLYSLMLHTVHFLALISRYDTIWRRVLNEGERPQWRAFYSSLVPRPTGDLSWKVLHGALSTGEYLARFTDSPAACPFCGKGESVFHAYFTCARLQPLLALLRKLYLQFWLHFSPHVYIFGRPVSRDNKEKDLLSNLLLALAKLVIHKSRKQCLEGGNPLPAEVLFRVLVRSRIRAEYTQAVFTGRLKEFADQWAIDGVLCSVSPDLVSVQTILTLPYLSAL
What are the official names of this protein?
Transposon TX1 uncharacterized 149 kDa protein, ORF 2.
Protein: RSGA_SALTY
Sequence: MSKNKLSKGQQRRVNANHQRRLKTSAEKADYDDNLFGEPAEGIVISRFGMHADVESADGEVHRCNIRRTIRSLVTGDRVVWRPGKAAAEGVNVKGIVEAVHERTSVLTRPDFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVGCETLQVEPLIVLNKIDLLDDEGMDFVNEQMDIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLGLQNEILTNDVSNVSGLGQHTTTAARLYHFPHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGHCKYRDCKHDADPGCAIREAVENGAIAETRFENYHRILESMAQVKTRKNFSDTDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_SINFN
Sequence: MTITIALPSKGRMKDDASAIFERAGMKIVAVGNDRSYRGRVEGWDDVEVAFLSASEISREVGSGAVDFGVTGEDLVREGIADVDARVEFAARLGFGHADVVVAVPEVWYDVDTMADLGDVAADFRARHGRRLAIATKYWRLTQQFFSGSHGIQLYRIVESLGATEGAPASGSADIIVDITSTGSTLKANHLKILSDGVILRSEACLVRARKPAHDGYPMIDRIISSVRSVL
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_FRATN
Sequence: MNKKILFLGVGGIGVSALAIAAKRLGAHVAGYDSAANKLTAKLEALGIVIFTSPSGVDVANFDIVVYSSAILSSHPLLSQARSLGIQCLQRAMFLAVLMKDFSYSLAITGTHGKTTTSSVLATLLCQLDKHSSFVVGGVVKYADSNIQVNGTDKLVIEADESDASFLFLSPQVVIITNIDLDHMATYNNSYQTLLENFTDFVSKESVKSIYLCVDDQGCRDLLAKYNQSDKNVTSYGFSINADVQIYDYHIIDEITHFKIRYKGDDLSFKLQLPGKYNVQNATACIIACLDLGFKYEDIRNALIKVTGVARRFDLYTKVISGHQVTVIDDYGHHPVEVANSISAVRDRYPNKKIIHVFQPHRYTRNRDLIKDWPKALSLADQLILLPTYSAGEQIIKGAESQDIAKGLSGYLLADGFDHAIYFLEKLANENTVILIQGAGDVTNLVEMLSE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBT3_ARATH
Sequence: MANRSEEAEYENDSRRNHQDKKKEGVLDLVLKRPLRWLRMLIEELHWSFFFGVIIVYGVSQGLGKGLSKVSTQYYFKDEQKIQPSQAQIYVGLIQIPWIIKPLWGLLTDVVPVLGYRRRPYFILAGFLAMISMMVLWLHTNLHLALALSCLVAGSAGVAIADVTIDACVTQCSISHPTLAADMQSLCGLCSSIGSLVGFSLSGVLVHLVGSKGVYGLLGVTAGLLVVVGMVLKESPSRSLGRKHVNDKFLDAGSAIWKTFQYGEVWRPCLFMLLSAAVSLHIHEGMFYWYTDSKDGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYFFIVVDEFVSHMISRIKWLPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSSWGGGVLLHALKVTRTQFDNLWLVIVIRSLLRVIPIGLVFLIPNVDSNSTILPAEMLTSRISEGVDTEKIEMTALISDEA
What is the function of this protein?
Could mediate folate transport.
What are the official names of this protein?
Probable folate-biopterin transporter 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PURA_THEKO
Sequence: MPSYIVVGGQWGDEGKGSVIAYLALKDEPEVIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQTKARLLVGAGVLVDPEVFFHELEHLKDFNVRGRVGIDYRCAIIEEKHKQLDRSNHHLHEEIGTTGSGCGPANADRVMRRAKLAKDIKELEPYLTDVAAEVNDALDDGKLVLIEGTQGFGLSLYYGTYPYVTSKDTTASAIASDVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPQEEAERLGLVEYGTVTGRRRRVGWFDFEFARYSARINGATMLALTMLDKYDGEAFGVTDYDKLPKRAKEFVEEIEERVGVPVGLIKTGPELEHVIDRRENI
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2A_BOTJR
Sequence: MRTLWIMAVLLVGVEGSLWQFGKMINYVMGESGVLQYLSYGCYCGLGGQGQPTDATDRCCFVHDCCYGKVTGCDPKIDSYTYSKKNGDVVCGGDDPCKKQICECDRVATTCFRDNKDTYDIKYWFYGAKNCQEKSEPC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that displays edema-inducing activities (activity that is inhibited by EDTA and dexamethasone), inhibits phospholipid-dependent collagen/ADP-induced platelet aggregation, possess hypotensive as well as anticoagulant activities.  In addition, this enzyme shows bactericidal activity against E. coli and S. aureus.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 BthA-1, svPLA2, BOJU-III, BthA-I-PLA2, Hypotensive phospholipase A2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y266_ARCFU
Sequence: MKKWIVLALTVTFWGLAFTAIKYSVRFLSPIAIASLRFAIANTLFAVIIILGKRIKWKDLPKVFALGIFGVSVYHVFLNLGEVYISSGVASVVISLAPIFVLILSAIFLRERITYSKVVGIIIAFLGVVVISEPSYANIYGIALVMVSTVAAAIYTTFGKSLLSKYNPITLTSNAMVLGSIPLYPFLPDSIRSLGGDLNLIGSIVFLGIFSTFFGYLGWYYFLEKEEASRASVFLLAIPVVSLLAGNILLAEPLTLRTVAGSGLVLLGIYIVVRKR
What are the official names of this protein?
Uncharacterized transporter AF_0266.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECF_LEPBL
Sequence: MFLKHLTLQNFRSYEELSLDFNSRLIFFVGDNGEGKTNLLEAICMLSWLKSFRESEDSNLIRWGSENYFLRGKIKGDQKESVLEVGFTAKPTVKRKLKFNQEEVKKRTDLIGKFITVLLTPMDLKIIEGGPAERRKFIDAFISSFDPFYLECLLEYNKILKHRNALLKTGISDASHLSIWDRKLIEKGVLILNKRKEIVFGLNSFYQPNLNKLSGGKDELEMIYGPNVKDKDEFVEKLGRNLGKDLRLGYTSVGIHRDDLFIGADKRDITEFGSQGQKRSTVIALKAATFNYYRNVLDTMPVLLIDDVIRELDVKRREYFVDLVINAGQAFFTTTDLEGIQDYVGKLKDQKQIFLIQQGNIQFAK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y625_MYCTO
Sequence: MSTHNDSAPTSRRRHIVRLVVFAGFLVGMFYLVAATDVIDVAAVRGAVSATGPAAPLTYVVVSAVLGALFVPGPILAASSGLLFGPLVGVFVTLGATVGTAVVASLVGRRAGRASARALLGGERADRTDALIERCGLWAVVGQRFVPGISDAFASYAFGTFGVPLWQMAVGAFIGSAPRAFAYTALGAAIGDRSPLLASCAIAVWCVTAIIGAFAARHGYRQWRAHARGDGADGGVEDPDREVGAR
What are the official names of this protein?
TVP38/TMEM64 family membrane protein MT0653.
What is the protein family that this protein belongs to?
Belongs to the TVP38/TMEM64 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS17_RHORT
Sequence: MPKRIMQGVVVSDKMDKTIVVQVERRFKHAVYKKFIKRTKKFAAHDELNQFKIGDLVRIRECAPISRRKTWEVVLDNAE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: CECR9_HUMAN
Sequence: MQSHLAPLACAAAAGRAGGSCQAAQPEDRRVLRYPGTAVMVTCPNRPLVPRPLLTPGGSRASLALCAFVAVPQRIPQPLLPAYILLMLPSLVVDMALPSSRLLRSIKPIQPASQVVRKERNPNPNCPQSDPLMKASSTSFLSHTYLINKTRSTTRKVEEHSWFTCTGAKYFAIPLAERNTKRLTKRSTHAQLLRGKQDGSEWVVPRSSASSNVLYH
What are the official names of this protein?
Putative cat eye syndrome critical region protein 9.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1774_YERPB
Sequence: MLAGMPSLSHEEQQEAVERIHKFMSEGMSSGEAIALVAAEIRERHQNDPQAMAIFEDHDFDEHTESDYRRDDEPDADDIEDLYEG
What are the official names of this protein?
UPF0181 protein YPTS_1774.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: HAP2_NEMVE
Sequence: MGRGQIIMILVGLLCLANESYSDVIAKSSLQMCENTGNSDDPYNVVDQKACEKKLIVTLSVRSGQNGTEFLKAVTNVSKVYDQTEKEMARLYNPFIITLAKTPVKLTYPYYYLAMVNNKPTERVVISDSKWHASGSYHACSDAWDDEDALCGFYTDAEGKPIWDSQGFCCRCTEQEKWRGSFNDKNPYSRAGINCKLFGTQAAAHCMTFDDLWYTVNEVGLWQMDFSIHVKAYDLVVEKVGNKTQSKWVDGGEIVIGPTIRSGVGVHGRLHATFIGEFQSHKQFPVLTTKYLLIPYVSEKVDPKTHPQFRNGPHDYMLIDKHEVNYKSSGPHECDKIGVSFSAFRAQAPMGCSQKQGDCLHNQPKDYFEEDTKRRASGKTPYYFPQKFGKLLGVNQRKDNNHFVLTYEVDEVMTSMVTLQISADDVILIYNRAEGKILRAYAQDFEALSRDGNLYVIVQNIGLVTADFYVVIKECSVGIGKLLEKAASINPQQTHSFTFSVKAQQWKGGDNFCIVQLYDARRKMVDSSNVTFRTTEPCVCASSCGCSCFKNGFKCTKREDRDFTKTKPKDSGLDLGFFPKLWNKIKNVWDTVTSVFNFMESGWALLGTALGLLSLGGLKAFLGFRKTGSRIARFGFGGANKGRVRRRDGSGRMVTMEFNETGDRIDPETKEVIEPRNKKKELLLNLFFFFILPFLLIYHLVGWIRWRMRKPGSEDEEQAGTGDEQGGASPLHNIEARAAVDQFLQPDTIVYHSYSQDDYVAQFLINPGKRFCMAGRMTSLSGPSADQFRFDLLQAIQIYEVIDNKRRRLESVNSLNAHYFSRLLNAEAMIDCLSLKPAFPCLNVNRKRKPKQK
What is the function of this protein?
During fertilization, required on male gametes for their fusion with female gametes (PubMed:25111819).  Probably initiates the fusion of gamete cell membranes by inserting part of its extracellular domain into the cell membrane of a female gamete (PubMed:20080406).
What are the official names of this protein?
Hapless 2, Generative cell specific 1.
What is the protein family that this protein belongs to?
Belongs to the HAP2/GCS1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: KSHB_MYCTO
Sequence: MTEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSPYTDDALAVTVKRTADGYASNWLCDHAQVGMRIHVLAPSGNFVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLLYANRDDRSVIFGDALRELAAKYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVPAQQVHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLDAPFSCREGHCGACACTLRAGKVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE
What is the function of this protein?
Involved in the degradation of cholesterol.  Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A.
What are the official names of this protein?
3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component, 3-ketosteroid-9-alpha-hydroxylase, ferredoxin reductase component, KSH, Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase, Rieske-type oxygenase, RO.
Protein: ORN_YERP3
Sequence: MAENQNNLIWIDLEMTGLDPERDRIIEIATLVTDANLNILAEGPVLAVHQSAEQLGLMDEWNVRTHTGSGLVERVKTSPFNDRDAELQTIEFLKQWVPAGVSPICGNSVGQDRRFLFRYMPELEAYFHYRYVDVSTLKELARRWKPEILAGFKKQNTHQALDDIRESVAELAYYREHFIQS
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPC6_MOUSE
Sequence: MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPVIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPILPPTGVVRAPCGLCPVFEDCHEGGEISPSNCIYMTEWLEF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  May direct RNA Pol III binding to the TFIIIB-DNA complex.  Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.  Acts as nuclear and cytosolic DNA sensor involved detecting AT-rich DNA, in innate immune response.  Can sense non-self dsDNA that serves as template for transcription into dsRNA.  The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).  Preferentially binds double-stranded DNA (dsDNA) (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC6, RNA polymerase III subunit C6, DNA-directed RNA polymerase III subunit F.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FEN11_PHYPA
Sequence: MGIKGLTKLIADNAHGAVKEQKFENYFGRKIAIDASMSIYQFLIVVGRSGSELLTNDAGEVTSHLQGMFNRTIRVLEAGLKPVYVFDGQPPDLKKRELAKRFARREDAAEDLVTAKETGNEADVEKYSKKTVKVTKQHNEDCRKLLRLMGVPVVEAPSEAEAECASLCKAEKVFAVASEDMDSLTYGSTRFLRHLMEPTSRKLPVLEFDIAKVLEGLGLNMDQFVDLCILCGCDYCDTIRGIGPQTALKMIRQHGSLEIVLENLNKDRYQVPDPWPYQEARRLFKEPLVTPPEKVPEFKWTAPDTEGLRQLLVEENGFNNDRVMKAIEKLKVAKNKASQGRLESFFGVSSSSSNKRKEAPDSEASAGKQVKTAAAVKPAKAASKKGPAKGGKKK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1-A, FEN-1-A, Flap structure-specific endonuclease 1-A.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: ZFN2A_MOUSE
Sequence: MEFPDLGKHCSEPTCKQLDFLPITCDACKQDFCKDHFSYVGHKCPFAFKKDVQVPVCPLCNAPIPVKRGEIPDVVVGEHMDRDCTFHPGRNRNKVFTHRCSKEGCRKKEMLQLACAQCHGNFCIQHRHPLDHNCQAGSSSASRGRTSTSRAAEQKPSGVSWLAQRLRRTVK
What are the official names of this protein?
AN1-type zinc finger protein 2A, Arsenite-inducible RNA-associated protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NLTPC_RICCO
Sequence: MKNVVFSVLLLLSFLFCLANTNEAAVPCSTVDMKAAACVGFATGKDSKPSQACCTGLQQLAQTVKTVDDKKAICRCLKASSKSLGIKDQFLSKIPAACNIKVGFPVSTNTNCETIH
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
What are the official names of this protein?
Non-specific lipid-transfer protein C, cotyledon-specific isoform, NS-LTP C, Phospholipid transfer protein, PLTP.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: GCH1_SALCH
Sequence: MPSLSKEAALVHDALVARGLETPLRPPMDELDNETRKSLIAGHMTEIMQLLNLDLSDDSLMETPHRIAKMYVDEIFAGLDYANFPKITLIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILTVLQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHP
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: SYC_ACIBC
Sequence: MQPFVLYNSEQRKKVEFVPRKEGHIDMYVCGMTVYDYCHIGHARVMVAFDYIIRFLRSQGWKVRYIRNITDIDDKIIKRANENGETIQQLTTRFIDAMNEDAANLGCLAPDEAPKATEYIDQMQNMIGNLVNKGAAYPASNGDVYFEVTKFEKYGRLSGRKLEDMQAGASERVDVEVEKKHPFDFVLWKHAKENEPSWASPWGNGRPGWHIECSAMSTCCLGNHFDIHGGGSDLMFPHHENEIAQSEASTGEQYVNYWMHVGFINVDGEKMSKSLGNFFTIRDVMEKFHPEVIRYFIVSSHYRSPVNFSDVALKEAKTSLTRFYHSFKAYQQVYGQTTTEALDQSFIERFNNAMCDDFNTAEAMAVLFELNKELNRAVKEEQADQATVLYSTLRHLTNILGLVQHNVDDFLKSDIGQDALALSDAEIEDFIQQRVDAKKAKDFAKADSIRQSLLEQGVVLEDTRQGTVWRRAD
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUX8_ARATH
Sequence: MDLQRGFVFLSLVLSFMIIETTAYRERQLLLLQPPQETAIDTANAVVTVQDRGLKTRRPEHKNAYATMMYMGTPRDYEFYVATRVLIRSLRSLHVEADLVVIASLDVPLRWVQTLEEEDGAKVVRVENVDNPYRRQTNFNSRFKLTLNKLYAWALSDYDRVVMLDADNLFLKKADELFQCGRFCAVFINPCIFHTGLFVLQPSVEVFKDMLHELQVGRKNPDGADQGFLVSYFSDLLDQPLFSPPSNGSVLNGHLRLPLGYQMDASYFYLKLRWNIPCGPNSVITFPGAVWLKPWYWWSWPVLPLGFSWHEQRRATIGYSAEMPLVIIQAMFYLGIIVVTRLARPNITKLCYRRSDRNLTTIQAGFKLIALLSVVAAYIFPFFTIPHTIHPLIGWSLYLMASFALSSISINTLLLPTLPVLTPWLGILGTLLVMAFPWYPDGVVRALSVFAYAFCCAPFVWVSFRKITSHLQVLIEKEVLFPRLGDSGVTSGFSKLY
What are the official names of this protein?
Putative glucuronosyltransferase PGSIP8, Glycogenin-like protein 8, Plant glycogenin-like starch initiation protein 8.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PSBZ_TETOB
Sequence: MTSVLQIALLALIAVSFALVVGVPVVFATPNGWSENKGIVFSGLSLWLVLVFAVGIFNSFVI
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: PDXA2_CLOBK
Sequence: MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNINSIKKADEGKFTLGTIDLIDLNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDAIATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEVRGMRVFFLTRHVSLRKACDLVTKERVLDYIIRCSEALEKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQKMGYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSVDHGTAFDIAGTGQASSVSMVEAIVLAAKYSPKFKK
What is the function of this protein?
Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).
What are the official names of this protein?
Putative D-threonate 4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family. PdxA2 subfamily.
Protein: TMCAL_STRS2
Sequence: MSISGIIAEYNPFHTGHKYLLEQAEGLKIVVMSGNFMQRGEPAIVDKWTRAQMALEHGADLVVEMPFLVSVQSADHFAKGAISILHRLGVEKLVFGTEEMLDYQKIADIYVDKSEEMENFVKNLPDNFSYPQKTQAMWQEFAGLTFTGDTPNHILALAYAKGVAGTGIQLSPVQRQGAGFHSEEVETSYASAIAIRKGADQLDLVRDFLPSASLFEEATKVSWRNYFPLLRYQITTHPDLSQVFQVNEELASRIRSAIGSVATVEELVEAVTTKRYTKARVRRVLTYILINAVETPLPDAVHVLGFSARGQAYLKQVKERVGLVTRIGKEPWDSLTQQADLVYQLGADAMAEQTYGRVPVRVE
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.