PharMolix/UniProtQA huggingface dataset:
Protein: ACDH_CUPTR
Sequence: MNKIRCALIGPGNIGTDLLYKLRRSDILEPVWMVGVEPTSEGLARARELGLKTTSDGIDGLLPHLEADDIRIAFDATSAYVHAEHSAKLTARGVRVIDLTPAAIGPFCVPPVNLAAHIGSNEMNVNMVTCGGQATIPMVYAVSRVQPVAYGEIVATVSSRSVGPGTRRNIDEFTRTTAGAIEAVGGARQGKAIIVINPAEPPLIMRDTIHCLTEDAPDVAAITASVHDMIAEVRKYVPGYTLKNGPVFDGKRVSIFLEVEGLGDYLPKYAGNLDIMTASAARTAECIAAAMRAGSPETATA
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: RPOA_METPP
Sequence: MQTNLLKPKAINVEPLSAAKGAHRAKVTLEPFERGYGHTLGNALRRVLLSSMVGYAPTEVTIAGVLHEYSAIDGVQEDVVHVMLNLKGVVFRLHNRDEVTLVLRKEGEGPVKAGDIQTPHDVEIINPDHVITHLSQGGKLDMQIKVEKGRGYVPGTMRRFGDEPTKSIGRIVLDASFSPVRRVSYTVESARVEQRTDLDKLVMEIETNGAITPEEAIRASAKILVEQLAVFAQLEGQINDIFDAQPAQRSTQFDPILLRPVDELELTVRSANCLKAENIYYIGDLIQRTETELLKTPNLGRKSLNEIKEVLASRGLTLGGRLENWPPQGLDKR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: MOBA_PSEMY
Sequence: MPVTHASFPCSVLLLCGGRGQRMGGRDKGLLEWRGRPLIAWLHEQVRPLSDDLILSCNRNHERYAHYADQLVTDEDQDFQGPLAGIRAGMAVAHHEQMLVLPCDAPLVDRQLLEALLAHAGARPVVVRQGDYWQPLFCLLPTALKADLEQLWQAGERSPQRWFSRLAPVAVECPIDDPRLANLNTPEMLAAASLSADARES
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BOPA_BURPS
Sequence: MINVDAFVASARSGARVVVGGDARGPVVSAARLGMKERLFAFLAHVPLLKHCDAVRRYAEQVRMENRRSLEVFVLALSKRYGPEGAKAAFDYGARRDGAPLDQRRVRNMVSIAEHFHGTGDAKPLARQMVFRSWECRGLDHPGHASLTIKNQADADAGRHVYEHVSWWPNQRLGSKEHFDRIEPKTLDGYRIDKRSEISSATEQRLREGDAARRKILADGFKYANQDERHDARFFPRAGQKLDKDAEWGLSARKVYFPAIGFNHDRRDTDRPRAFVLFGLNEAAMLRDARTVKEGAKSGELMYQMISKKENCASMALRVLRAGGAEHFVPYTAAWISEDPNHAHAYALAVQARIDALNQRRADVERRCERLRDSASVRQAWRAFSEAGGASASPLAEDAGRGRASAHMRQARLDEHAREVERIGAYFAELSAGRSGKHRDRADAALADAMKRCAPSARDDVAALTRKASVLVETLGRHLDAPPPSDSSALRRLAAHAMIGRIEAFMAAAIAA
What is the function of this protein?
Plays a role in mediating bacterial evasion from the host autophagic pathway.
What are the official names of this protein?
Effector protein BopA.
What is the protein family that this protein belongs to?
Belongs to the BopA/IcsB family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the bsa type III secretion system.
Protein: RL18A_HALLT
Sequence: MSTYTVTGQFQSRDGFQPFTKDVEAENEDLARERIYTTVGSQHNRKRPQIEIKEVSAA
What are the official names of this protein?
50S ribosomal protein L18Ae, 50S ribosomal protein L20e, 50S ribosomal protein LX.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
Protein: RPS4R_ARATH
Sequence: METSSISTVEDKPPQHQVFINFRGADLRRRFVSHLVTALKLNNINVFIDDYEDRGQPLDVLLKRIEESKIVLAIFSGNYTESVWCVRELEKIKDCTDEGTLVAIPIFYKLEPSTVRDLKGKFGDRFRSMAKGDERKKKWKEAFNLIPNIMGIIIDKKSVESEKVNEIVKAVKTALTGIPPEGSHNAVVGALGNSDAGTSSGDKKHETFGNEQRLKDLEEKLDRDKYKGTRIIGVVGMPGIGKTTLLKELYKTWQGKFSRHALIDQIRVKSKHLELDRLPQMLLGELSKLNNPHVDNLKDPYSQLHERKVLVVLDDVSKREQIDALREILDWIKEGKEGSRVVIATSDMSLTNGLVDDTYMVQNLNHRDSLQLFHYHAFIDDQANPQKKDFMKLSEGFVHYARGHPLALKVLGGELNKKSMDHWNSKMKKLAQSPSPNIVSVFQVSYDELTTAQKDAFLDIACFRSQDKDYVESLLASSDLGSAEAMSAVKSLTDKFLINTCDGRVEMHDLLYKFSREVDLKASNQDGSRQRRLWLHQHIIKGGIINVLQNKMKAANVRGIFLDLSEVEDETSLDRDHFINMGNLRYLKFYNSHCPQECKTNNKINIPDKLKLPLKEVRCLHWLKFPLETLPNDFNPINLVDLKLPYSEMEQLWEGDKDTPCLRWVDLNHSSKLCSLSGLSKAEKLQRLNLEGCTTLKAFPHDMKKMKMLAFLNLKGCTSLESLPEMNLISLKTLTLSGCSTFKEFPLISDNIETLYLDGTAISQLPMNMEKLQRLVVLNMKDCKMLEEIPGRVGELKALQELILSDCLNLKIFPEIDISFLNILLLDGTAIEVMPQLPSVQYLCLSRNAKISCLPVGISQLSQLKWLDLKYCTSLTSVPEFPPNLQCLDAHGCSSLKTVSKPLARIMPTEQNHSTFIFTNCENLEQAAKEEITSYAQRKCQLLSYARKRHNGGLVSESLFSTCFPGCEVPSWFCHETVGSELEVKLLPHWHDKKLAGIALCAVVSCLDPQDQVSRLSVTCTFKVKDEDKSWVPYTCPVGSWTRHGGGKDKIELDHVFIGYTSCPHTIKCHEEGNSDECNPTEASLKFTVTGGTSENGKYKVLKCGLSLVYAKDKDKNSALETKYDMLIGKSFQETSEGVDGRVKKTKGKYVMPVEKNFQETTEGVDGRVKKKKKTRMDNGRPKKKQRSGRDDNQTRMQVELQEGNINSVIMHTVKNF
What are the official names of this protein?
Inactive disease resistance protein RPS4, Resistance to Pseudomonas syringae 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYD_MYCPA
Sequence: MTRSPCSTTSRWISSMSTSEYRAVDAESDLPISAAELAALASQLYAASIRPGPDSPPQQAPVAPRGSVPDATAATSAGRTAAGTADVYPGPVPQVGGRDVYLPPPASPAPEAPPQAAPPAPRGSAPDATAATSAGRAAAGTSDVYSSWVPQLGVADIYLGAPTPAGPEAPPQSAPPAPRGQVPDTTAAATAYGADLSAFAVPTGIVSTAPGVQAGTAPPVPVVPRAATAPSWLPEAPSVADLGWSDAPAPDAPAGDEHDYHFLTKTDPVPQFRDEHEVFDVAAIRSDFPILKETVNGKPLIWFDNAATTQKPQVVIDRLSHFYAHENSNIHRAAHELAARATDAYEEARDTVAEFIGAPSSDNIVFVRGTTEAINLVAHAWGAKHLQPGDEIVITHLEHHANIVPWQLISQKTGAILKVAPIDDAGNLLLSEFEGLLGPRTKLVAASHVSNALGTVMPVDKIVELGHRYGARVLIDGAQSIQHIPIDVAELGADFFVFSGHKIYGPTGIGALYGTEEALTETPPWQGGGHMIADVTLERSLYQGPPTKFEAGTGNIADAVGLTEALRYVQRLGVERIAAYEHALLEYATPRLADIPGVRLIGTAQEKASVLSFVLAGHEPLEVGKALNAEGIAVRAGHHCAQPALRRLGLEATVRPSFAFYNTFEEIDVFLRAVRRIAEGGANVG
What is the function of this protein?
Cargo protein of a type 2A encapsulin nanocompartment involved in sulfur metabolism.  Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.
What are the official names of this protein?
Probable cysteine desulfurase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Encapsulin nanocompartment. Cell membrane.
Protein: L37A1_HUMAN
Sequence: MSSAQCPALVCVMSRLRFWGPWPLLMWQLLWLLVKEAQPLEWVKDPLQLTSNPLGPPESWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQESTENLVPFLDTWDSAGEQPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLAEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESKTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPTTEETSTQPPDLGLAIIPEPTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEPAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDLYKPLSATRINNHAWKLHKKSSNEDKILNRDPGDSEAPTEEEESEALP
What are the official names of this protein?
Leucine-rich repeat-containing protein 37A.
What is the protein family that this protein belongs to?
Belongs to the LRRC37A family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PSAF_MASLA
Sequence: MQRLFALILAIFLWFHFAPPAQALGADLVPCSESPAFQQRAQVARNTTADPESGKKRFERYSQALCGPEGLPHLIVDGRLDHAGDFLIPSILFLYIAGWIGWVGRAYLQTIKKQGSNVEQKEIQIELPIALPIMLSGFAWPAAAIKEFLSGELTAKDEEITISPR
What is the function of this protein?
Probably participates in efficiency of electron transfer from plastocyanin to P700 (or cytochrome c553 in algae and cyanobacteria).  This plastocyanin-docking protein contributes to the specific association of plastocyanin to PSI.
What are the official names of this protein?
Photosystem I reaction center subunit III, PSI-F.
What is the protein family that this protein belongs to?
Belongs to the PsaF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: ENO_SYNFM
Sequence: MSEILSVKAREILDSRGNPTVEAEVILDSGYSGTAAVPSGASTGSREALELRDGDPARYLGKGVLQAVQNVNDEIAPKVIGMDGRDQVGLDSFLIELDGTENKGRLGANAILSVSMAAAKAAAAECELPLYRYLGGAMASLLPVPMMNVINGGAHADNNVDIQEFMIVPAGAPTFGEALRMGAETFHNLKKVLKSKGLNTAVGDEGGFAPNLSSNEEAMEVLMQAIEAAGYRPGEDIYIAIDAAASEFYKDGSYHMSAEQSPTKSAEEMIAFYEAWAGRYPLICIEDGMAEGDWGGWQALTRKLGYNVQLVGDDVFVTNTSIIAKGIADGVANSVLIKLNQIGTVTETLQAINMAFKAGYTVVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAKYNQLLRIEEELGASGCYAGMSAFRV
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: VERC2_PENPO
Sequence: MLCWELANRRKRIGPNRFGFPIAILTRQQLIEVLYTALSDKSKVKTGKKVVRIESEERRITTWTEDGSEYEGELVVGADGVHSVTRSEMWRAADNQQPGFIQEEEKYSLSAEYSCIWGLSTPVPGIRQGEQIIRSYDRLTFLIFPSQNGCLGWFAIQKLNRKHVYPDIRPFSQKDTLARCEALRDLPIWNDVKFGDLLTLTEVCAMTPLEENLFQTWNYGRILCIGDSISKLTPNIAQGANTAIEGAAAVANGLHQLLHHNGLNQPSYDEIQEVLGRYSQSQRKRMKKLHWISHMVTRLQSREGLINKFVGRYIYSHTGNSTFYLTGKMIAQGPVLNYLSTPKEIEIGLRASFDQYGKDGGDMPWKTTIMFIALLTIVVLIYSFI
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the neurotoxin verrucosidin, a methylated alpha-pyrone polyketide that inhibits oxidative phosphorylation in mitochondria and thereby causes neurological diseases (PubMed:34093475).  The carbon backbone of verrucosidin is synthesized by the HR-PKS verA, and further modified by the other verrucodidin cluster enzymes (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase verC2, Cluster 4 protein C2, Verrucosidin biosynthesis cluster protein C2.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MNTP_CITK8
Sequence: MNITATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGLGMLASKFVLEWNHWVAFILLVFLGIRMIIEGVRGGNDEDDEPLRRHSFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGIMVGRFIGPLLGKRAEILGGAVLIGIGAQILWTHFHG
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GMHA_YERPE
Sequence: MYHDLIRSELNEAADTLANFLKDDSNIDAIQRAAILLADSFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHLSCVSNDFGYDYVFSRYVEAVDREGDVLLGISTSGNSGNIIKAIEAARAKGMKVITLTGKDGGKMAGSADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVKA
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK5_CHLAT
Sequence: MVQRLKAIYLEKAAPRLREMFEYKNVHQIPRIEKIIINCGLGEASQNAKSLDSAMKELSIIAGQKGVITRAKKAIANFKLRKDMPVGISITLRGNSMYAFLDRLINLALPRIKDFQGVSSKGFDGHGNYNLGLKEQLMFPEINFDQIDQIRGMDISIVTTCNTDSEGFYLLETLGMPFKEKFTKN
What is the function of this protein?
Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L5, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DNAT_SALA4
Sequence: MSSRILTSDVIGIDALLHDHHAVLAKSTGGAVAVFANNAPAFYAVTPARMAELLALEEKLSRPGSDVALDAQFYEEPEAAPVAIPCGKFAMYPAWQPDADFQRQAALWGVALREPVTAEELAAFIAYWQAEGKVFHHIQWQQKLARSVQISRSSNGGMPQRDINSVSEPDNHIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: ABLB1_PHYIT
Sequence: MRSLLLTVLLNLVVLLATTGAVSSNLNTAVNYASTSKIRFLSTEYNADEKRSLRGDYNNEVTKEPNTSDEERAFSISKSAEYVKMVLYGFKLGFSPRTQSKTVLRYEDKLFTALYKSGETPRSLRTKHLDKASASVFFNRFKKWYDKNVGPS
What is the function of this protein?
Secreted effector that acts as an elicitor of hypersensitive response (HR) specifically on plants carrying defense protein RGA2/Rpi-blb1 (PubMed:18682852, PubMed:19888819, PubMed:19794118, PubMed:20479869, PubMed:21483488).  Enhances P. infestans colonization of plant hosts Nicotiana benthamiana and potato Solanum bulbocastanum leaves (PubMed:28350531, PubMed:30329083).  Associates with host legume-type lectin receptor kinases and disrupts attachments between the host plasma membrane and cell wall (PubMed:14999409, PubMed:21483488).
What are the official names of this protein?
RxLR effector protein Avrblb1, Avirulence protein Avrblb1, In planta-induced protein O1, IPI-O1.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus, host nucleolus. Host nucleus. Host cell membrane.
Protein: BIG3_ARATH
Sequence: MASTEVDSRLGRVVIPALDKVIKNASWRKHSKLAHECKSVIERLRSPENSSPVADSESGSSIPGPLHDGGAAEYSLAESEIILSPLINASSTGVLKIVDPAVDCIQKLIAHGYVRGEADPTGGPEALLLSKLIETICKCHELDDEGLELLVLKTLLTAVTSISLRIHGDSLLQIVRTCYGIYLGSRNVVNQATAKASLVQMSVIVFRRMEADSSTVPIQPIVVAELMEPMDKSESDPSTTQSVQGFITKIMQDIDGVFNSANAKGTFGGHDGAFETSLPGTANPTDLLDSTDKDMLDAKYWEISMYKSALEGRKGELADGEVEKDDDSEVQIGNKLRRDAFLVFRALCKLSMKTPPKEDPELMRGKIVALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASNLMIIFQLSCSILLSLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPDFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGTVTTLLPPQEAAMKLEAMKCLVAVLRSMGDWVNKQLRLPDPYSAKMLEIVDRNLEEGSHPVENGKGDGGHGGFERSDSQSELSSGNSDALAIEQRRAYKLELQEGISIFNQKPKKGIEFLIKANKVGDSPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFEFQGMEFDEAIRAFLRGFRLPGEAQKIDRIMEKFAERFCKCNPKDFSSADTAYVLAYSVILLNTDAHNPMVKSKMTADGFIRNNRGIDDGKDLPEEYLRALYERISRNEIKMKDDGLGPQQKQPTNSSRLLGLDTILNIVVPRRGDDMNMETSDDLIRHMQERFKEKARKSESVYYAASDVIILRFMVEVCWAPMLAAFSVPLDQSDDAVITTLCLEGFHHAIHVTSVMSLKTHRDAFVTSLAKFTSLHSPADIKQKNIEAIKAIVKLAEEEGNYLQDAWEHILTCVSRFEHLHLLGEGAPPDATFFAFPQTESGNSPLAKPNSVPAIKERAPGKLQYAASAMIRGSYDGSGVAGKASNTVTSEQMNNLISNLNLLEQVGDMSRIFTRSQRLNSEAIIDFVKALCKVSMDELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSDNLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVVVMRKSGAVEIRELIIRCVSQMVLSRVDNVKSGWKSMFMIFTTAAHDAHKNIVFLSFEMVEKIIRDYFPHITETETTTFTDCVNCLVAFTNCKFEKDISLQAIAFLQYCARKLAEGYVGSSLRRNPPLSPQGGKIGKQDSGKFLESDEHLYSWFPLLAGLSELSFDPRAEIRKVALKVLFDTLRNHGDHFSLALWERVFESVLFRIFDYVRQDVDPSEDDSTDQRGYNGEVDQESWLYETCSLALQLVVDLFVNFYKTVNPLLKKVLMLFVSLIKRPHQSLAGAGIAALVRLMRDVGHQFSNEQWLEVVSCIKEAADATSPDFSYVTSEDLMEDVSNEDETNDNSNDALRRRNRQLHAVVTDAKSKASIQIFVIQAVTDIYDMYRMSLTANHMLMLFDAMHGIGSNAHKINADLLLRSKLQELGSSLESQEAPLLRLENESFQTCMTFLDNLISDQPVGYNEAEIESHLISLCREVLEFYINISCSKEQSSRWAVPSGSGKKKELTARAPLVVAAIQTLGNMGESLFKKNLPELFPLIATLISCEHGSGEVQVALSDMLQTSMGPVLLRSCC
What is the function of this protein?
Activates the ARF proteins by exchanging bound GDP for free GTP.  Plays a role in vesicular protein sorting (By similarity).  Involved both in the nuclear division phase and in the nuclear fusion phase.
What are the official names of this protein?
Brefeldin A-inhibited guanine nucleotide-exchange protein 3, BIG3, ARF guanine-nucleotide exchange factor BIG3, Protein EMBRYO SAC DEVELOPMENT ARREST 10.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Soluble and partially membrane-bound.
Protein: BIN1_HUMAN
Sequence: MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVP
What is the function of this protein?
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling.  Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653).  Is a negative regulator of endocytosis (By similarity).  Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792).  In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity).  May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822).  Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).
What are the official names of this protein?
Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1.
What are the subcellular locations of this protein?
[Isoform BIN1]: Nucleus. Cytoplasm. Endosome. Cell membrane, sarcolemma, T- tubule. SUBCELLULAR LOCATION: [Isoform IIA]: Cytoplasm.
Protein: SYK_HELPG
Sequence: MFSNQYIQQRIHKANSLREEGKNPYKNGLKRSLTNAAFLEKYAYVKDLEEPKDKEKCESIVGRVKLLRLMGKACFIKIEDESAILQAYVSQNELNDEFKSLKKHLEVGDIVLVKGFPFATKTGELSVHALEFHILSKTIVPLPEKFHGLSDIELRYRQRYLDLIVNPGVKDVFKKRSLIVSSVRKFFEMEGFLEVETPMMHPIPGGANARPFITYHNALEVERYLRIAPELYLKRLIVGGFEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLKTLNLDSKIIYNDMEVDFNQTSVISYLDALETIGGISRGILEKEDRLLAYLLEQGVKVEPNLTYGKLLAEAFDHFVEHKLINPTFVTQYPIEISPLARRNDSNPNIADRFELFIAGKEIANGFSELNDPLDQLERFKNQVAEKEKGDEEAQYMDEDYVWALAHGMPPTAGQGIGIDRLVMLLTGAKSIKDVILFPAMRPVKNDFNVESGE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3A_METTP
Sequence: MARRAQRKAERAKVKQWYKVLAPEMFGRTPVGETLANDPNKLLGRVIETTLGDLTNNFSKQNTKLRFKIDAVAGDTAYTKFIGHEMTTDYIRSLVKRRTSRIDAVVDVTTSDGYLVRVKPSCFTVKRARANQVKAIREISRQVIISRAGNIDLNGLIQEVVLGKLSLDIYKDAKAVYPLRRVEIRKTEILAGPGEVPHPAAVPEPTVTAGS
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: PURL_SULDN
Sequence: MSQQLQEIEKVLSSHKLSGDDYAHIKQILGREPNLVEIGIFSAMWSEHCSYKSSKVHLSGFPTKAPWVIQGPGENAGVIDIGGGYAAVFKMESHNHPSFIEPYQGAATGVGGIMRDVFTMGARPIANLNALRFGDVLKDNKTSAHQRYLVRGVVAGIGGYGNCMGVPTIGGETSFDECYNGNILVNAFTLGLAKSDEIFYGRADGIGNPVIYVGAKTGRDGLGGAVMSSDSFTEESKSLRPTVQVGDPFTEKLLLEACLELFKTDHVVGIQDMGAAGLTSSSFEMAGRSGSGMIMHLDRVPAREEGMTPYDFMLSESQERMLLCAKKGSEAEIIKIFEKWDLDAAVIGEVTATGNMELFWHGDKVAEVPVNPVSEEAPVLNRPMSRPAYLDKIASVTIDDFARVPNQEAFERLTKSMEVVDKSWIYTQYDSMVQTNTIKKGGMLDASVVRVKENGKALAMSADCNVRYCYIDPKGGAAAAVIESGRNVAMSGARPLAITDCLNFGNPENPEVMWQFGQSCLGIKEACSALTTPVIGGNVSLYNETNGVSVFPTPSIATVGVNDDQNKVLMSSFQGEGNTLYLVGESNSEFGGSLYMKEICGVVAGVLPEIDYEKELTLWDLVIEANKKGILECAKDASSGGVAIALAKMAAVSGLGCSARMLVNDERDIFAESMSRAIIEVKQENSASFESMAGVLQCQKLGTVGGDIVKINNVSMSMKELQDNYFNTFKRVIERDI
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACOHC_CUCMC
Sequence: HEAKTENAVQANMELEFKRNRERFGFLKWGSSAFHNMLVVPPGSGIVHQVNLEYLGRVVFNTNGLLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFKLVGKLRNGVTATDLVLTVTQMLRKHGVVGKFVEFYGEGMGELSLADRATIANMSPEYGATMGFFPVDHVTLQYLKLTGRKDETISMIESYLLANKMFVDYSEPQVERVYSSHIELNLSDVEPCISGPKRPHDRVPLKEMKADWHACLDNRVGFKGFAIPKEAQVKVAEFNFHGSPAQLRHGDVVIAAITSCTNTSSSVMLGAALVAKKACELGLEVKPWIKTVLLQALGVVTKYLAKSGLQKYLNQLGFNIVGYGCTTCIGNSGDIDESVASAITGNDIVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGTVDIDFESEPIGVGKDGKKVFFRDIWPTSEEVAVVVNSNVLPDMFRATYQAITEGNATWNLLSVPEGTLYSWDPTSTYIHEPPYFKDMSMSPPGPHGVKNAYCLLNFGDSITTDHISPAGSIHKDSPAAKYLLERGVDRRDFNSYGVAVVMMRLWHVHFANIRIVNKLLKGEVGPKTIHIPSREKLSVFDAAMRYKSEGQDTIILAGAEYGIGSSRDWAAKGPMLLGVKAVIAKSFERIHRSNLVGMGIIPLCFKAGEDADSLGLTGHERFTIDLPSNVGEIRPGQDVAVVTDTGKSFSCILRFDTEVELAYFDHGGILQYVIRNLIHSKH
What is the function of this protein?
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
What are the official names of this protein?
Aconitate hydratase, Aconitase, Citrate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.