PharMolix/UniProtQA huggingface dataset:
Protein: TS101_HUMAN
Sequence: MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
What is the function of this protein?
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.  Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs).  Mediates the association between the ESCRT-0 and ESCRT-I complex.  Required for completion of cytokinesis; the function requires CEP55.  May be involved in cell growth and differentiation.  Acts as a negative growth regulator.  Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P.  This interaction is essential for viral particle budding of numerous retroviruses.  Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).  It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426).
What are the official names of this protein?
Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring. Nucleus. Note=Mainly cytoplasmic. Membrane- associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis.
Protein: GK_EHV1K
Sequence: MLLGGRTAYLSVLGLITAYAAFTIWYTLTAQLHNPCVYATVSIDSKDGIAAKWEVYNSTIVYAYPENGAKRFSDGLSGFDYVCRENWVNESKLDVLKNMKELHDKVRIVVGTRNCRAYLWSVQLQMITGAWLIYIAFLCLRQERRLLGPFRNQNEFLSPTGYTFNYATYTLATTVLKTHYTKFALLLCEASLRRVALSRTFKRDPIGFLCEHSAALALIGLEVGTHFVARLLVVGTVTLVHTPCSQIYPIYLKLASWGFVVAVTIVEIVAIIYEKPPKTGSSANPPTPATHGVKGLCTSCCSTVLANLCGKLVYLLLVIGAVSILLHYEQRIQIGLLGESFSS
What is the function of this protein?
Glycoprotein that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes.
What are the official names of this protein?
Envelope glycoprotein K, Syncytial protein.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein K family.
What are the subcellular locations of this protein?
Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with UL20 to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Cell surface expression of gK is required for virus-induced cell-to-cell fusion. Likely not present in extracellular virions (By similarity).
Protein: PURA_BRASB
Sequence: MANVVVVGAQWGDEGKGKIVDWLSEQADIVVRFQGGHNAGHTLVINGATYKLALLPSGVLRTGKLSVIGNGVVFDPQAFLDEVSKLQSQGVAISPDNLRVAENVTLILPLHRELDALRESASAATAIGTTRRGIGPAYEDKVGRRAIRLMDLADLDTLPHKIDRLLAHHNALRRGLGLEQIDGKDILRELTAFAPKLLPYAETVWRLLDIKRREGKRMLFEGAQGALLDVDHGTYPYVTSSNTVAAQAATGAGLGPGAIGYVLGLCKAYTTRVGQGPFPTEQDNETGRKIGERGREFGTNTGRPRRCGWFDAVLVRQAVRTCGINGLALTKLDILDGFDTIDVCTGYRLDGKEIDHFPAGEGAQARVEPIYETIEGWKQPTANARSWADLPAQAIKYVRRIEELVGCPIALLSTSPEREDTILVQNPFEA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DERL1_BOVIN
Sequence: MSDIGDWFRSIPTITRYWFAATVAVPLVGKLGLISPAYFFLWPEAFLYRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ
What is the function of this protein?
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins.  Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane.  This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome.  The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first.  May mediate the interaction between VCP and the misfolded protein.  Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.  By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.
What are the official names of this protein?
Derlin-1, Der1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the derlin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GLGB_CLOP1
Sequence: MRNCKELKHEKNGNVTEKIGKNKGKSKKVSKDESLLSFDLFLEGKEHSAYKFMGAHFVTENRKRGVRFTTWAPRSSKIYVIGDFNNWELKEEYSMKKINERGIWSLFLPKLEEGIKYKFAVVNECGNNTVYKADPYAFKSELRPNTASVLTKIKSFRWGDKRWLNKREKEGLDNKPMNIYELHLGSWKRKDGEFMTYEEISEVLVEYVKEMGYTHVEFMPINEHPLDASWGYQGVGYYSVTSRYGDLNGLKALINKLHKNNIGVLLDWVPSHFCKDEHGLFMFDGSPTYEYGAWWKANNEGWGTCNFDLGRPEVKSFLFSNAMYWINEFHIDGLRVDAVSNMLYLDYGREYGEWEPNIYGGNGNLEAIAFLKELNTIIKKEGKGAITVAEESTSWEGITKPVEEDGLGFDYKWNMGWMNDTLSYIELDPIYRKYHHNKMNFSMMYNYSEKFILPISHDEVVHGKKSLINKMWGDDWKKYAGLRLYASFMMGHPGKKLMFMGCEFGQFVEWREWEELQWNIIEEFDIHKKTQEYFKALNHFYLENSSLWSLDYEEEGFKWIDADNSEESVLSFIRIGKNKKEKLIFICNFTPEVYYDFKVGVPELGEYVEVFNSDSLEFGGAGNIMGDSILKATEESFKDFDYSIIVKVPPLGTLVLKVK
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: GATA_NEIMA
Sequence: MTQYTLKQASVLLQSKQISAVELASAYLAAIAEKNPALNGYITIDQDKTLAEARAADERIAQGNASALTGIPVAYKDIFCQTGWRSACASKMLDNFISPYTATVVQKLLDEGMVTLGRTNMDEFAMGSTNENSFYGAAKNPWNPEHVPGGSSGGSAAVVAARLAPAALGSDTGGSIRQPASHCGITGIKPTYGTVSRFGMVAYASSFDQAGPMAQTAEDCAILLNAMAGFDPKDSTSLEREKEDYTRDLNQPLKGLKIGLPKEYFGEGNSADVLTALQNTIDLLKAQGAELIEVSLPQTKLSIPAYYVLASAEASTNLSRYDGVRYGHRAAQFSDLEEMYGKTRAEGFGSEVKRRIMIGTYVLSHGYYDAYYLKAQKLRRLVADDFQTAFARCDLILAPTAPSAAPKIGADASPVETYLSDIYTIAVNLAGLPALTLPAGFSSGGLPIGVQLIGNYFSEAKILGAAHQIQLNSDWHGKRPE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: YP038_YEAST
Sequence: MVCRFVHHSRVIFISIYDFLSTKGKKNMYNYTQEKKTKQKNTFTQASIYYENFFESYRTISCL
What are the official names of this protein?
Uncharacterized protein YPL038W-A.
Protein: LEC1_CAEEL
Sequence: MSAEEPKSYPVPYRSVLQEKFEPGQTLIVKGSTIDESQRFTINLHSKTADFSGNDVPLHVSVRFDEGKIVLNSFSNGEWGKEERKSNPIKKGDSFDIRIRAHDDRFQIIVDHKEFKDYEHRLPLSSISHLSIDGDLYLNHVHWGGKYYPVPYESGLANGLPVGKSLLVFGTVEKKAKRFHVNLLRKNGDISFHFNPRFDEKHVIRNSLAANEWGNEEREGKNPFEKGVGFDLVIQNEEYAFQVFVNGERYISFAHRADPHDIAGLQISGDIELSGIQIQ
What is the function of this protein?
Binds galactose.
What are the official names of this protein?
32 kDa beta-galactoside-binding lectin, 32 kDa GBP.
Protein: PNP_RICFE
Sequence: MFNEITKSVTWNGKVLELSTGKIARQADGAVTVKMGNSVLLCTAVVAKKAKEGIGFFPLTINYREMAYATGKIPGGFFKREGKASDREVLVSRLIDRPIRPLFHPAFVNETHVTCSVLSYDPETPVDILAIIGASAALSLSPAPYLEIVAASKVGLINGEFVLNPTLELLKTSQLDLVVAGTSDSVMMVESEAHLLAEEQMLEAVKFGFESFQPVIKIIKELAEEAKKPKLEMQDLYPASLKKEIEKLFVKEIEQAFAIKSKQERSTNLDLIPEKVLTHFVSDIENKKYSNYQIESALKSIESDILRNEILEKNRRIDGRSTTDIRQIACEIGLLPSAHGSALFTRGETQSLVSTTFGTSLDEQIVDSLEGEYKERFMLNYIFPPYSVNEAMPMKAPSRREVGHGKLAWRAINPILPNKVQFPYSIRVVAETTESNGSSSMATVCGSSLALMYAGVPIKAPVAGIAMGLVKEGKKFAVLSDILGDEDYFGDMDFKVAGTSEGITALQMDIKISGVDFKIMTVALEQARLGRLHILEQMNKVISKPNSELSKNAPSTTTIKIDKDKIRDIIGPGGKVIKEICETSGAKIDISDDGSVSVYASDRDKLKVALDKIKAIAVEPEIGEIFNGTVMKVLDSGAFINYLGNKDGFVHISEISEERIETVSSVLKQGDIVKVKLIGFDNKGKAKLTIKNADKDKSSNNPKPKNNVNNAKENSEPERRDSSKKRAWNEDSNNDKEEAITERKYFN
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHP2_XENLA
Sequence: MTKVKKEECEEVPETPSKSYDELLSYLNPVAKPLAGRKLTKKLYKCVKKAIKQKNIRRGVKEVQKFINKGEKGIVVMAGDTLPIEVYCHIPVMCEDRGIPYSYVPSKSDLGAAAGSKRPTCVILIKPHEDYQEAYDECLEDVQALPLPY
What is the function of this protein?
Required for ribosome biogenesis.  Part of a complex which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit 2-like protein, Nucleolar protein family A member 2-like protein, snoRNP protein NHP2-like protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PYRG2_CHICK
Sequence: MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERHGDYLGKTVQVVPHITDAVQEWVMNQAKVPVDDDRKEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQPNATGEQKTKPTQNSVRALRGLGLSPDLIVCRSAKPIEMAVKEKISMFCHVEPEQVIFIHDVSSTYRVPILLEEQGIIKYFKQRLNLPIDDQPSDLLMKWKKMADRYERLLKVCSIALVGKYTKLSDCYASVFKALEHSALAINHKLDLMYIDSTELERSTEVENSVKYHQAWHKLCKADGILVPGGFGIRGTEGKLQAISWARTKKKPFLGVCLGMQLAVVEFARNCLNWKDANSTEFDPDTKSPVVIDMPEHNPGDMGGTMRLGKRRTVFKTQNSILRKLYGDEMFVEERHRHRYEVNPELTHCFEEKGLKFVGHDTEGNRMEMIELENHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGTLNAYLQRGCKLSPSESYSDLSDDSSPEKEFPKSETS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity).
What are the official names of this protein?
CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: RS29_GUITH
Sequence: MSHKNIWNKHSRTYGKGSRGCRICGNRSGLIRKYGLSICRQCFREKSQNLGFDKYR
What are the official names of this protein?
40S ribosomal protein S29A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: KUP_PSEAE
Sequence: MSDAATRAEETSEGHSSSAIGLMVGAVGVCYGDIGTSPLYTLKEVFIGGYGVQANHDGVLGVLSLIFWSLVWVVSIKYVIFVLRADNQGEGGVMALSALARRAAAPFGRLQTFVVVAGLIGAALFYGDSMITPAISVLSAVEGLEIAFDGLEHWTVPLALIVLIGLFLIQKHGTARIGILFGPVMVLWFGALAALGVYGVIQQPEVLQAMNPVWAVRFFSSHPGIGVAILGATVLALTGAEALYADMGHFGRKPIARAWFLLVLPALVLNYFGQGATILSNAEAARNPFYLLAPGWALLPMVALSTLATVIASQAVISGAFSLTRQAIQLGYVPRMTIQHTSSHEQGQIYIGGVNWALMVGVVLLVLGFESSASLAAAYGVAVTGTMLITTLLMGVVIWRLWKWPLWLGVPFFCVMLAVDSLFFAANLPKVIQGGAFPVIAGIVIFILMSTWKRGRQLLVERLDEGSLPLSVFISSMRVQPPHRVQGTAVFLTARTDAVPHALLHNLLHNQVLHEQVVLLTVVNEDSPRVSPDRRFEVEAYGDGFFRVILHFGFMEEPDIPAALRLCHLNELDFSPMRTTYFLSRETVIPSKRIGMARWREGLFAFLLKNANGNLRYFNLPLNRVIELGTQVEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BRX1_SCHPO
Sequence: MSTVYKLKTSERAPKNEDEDEEYVPVQNGQGNKHSAGFVPIKQKVLVLSSRGVTYRQRHLLNDLVSMMPHSKKDSKLDSKDRLYQLNELAELYNCNNIFFFESRRREDLYLHIARAPNGPTVKFHVENLHTMDELNMTGNALKGSRPILSFDKTFDTAPHLKVVKELLQQTFGIPKGARRSKPFIDRVCTLTIADGKIWFRNYEIRENEDKSKDPVTLIEIGPRFVMTIINILEGSFGGPVIYKNDTFVSSTMVRAAIRNQAAQRYVNRQESKLERQVRAQQNVIPEDPLDNVFA
What is the function of this protein?
Required for biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein brx1.
What is the protein family that this protein belongs to?
Belongs to the BRX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm.
Protein: MED5_ASPFU
Sequence: MTSPVQWGTFFHQCLLHRIDANEFRNLSKLLLQKCPIAETALLDALLQTRSESRIKWDPLLPLYIDCLCRTGRVRTSTVLTSLLKYSSIHDKPQLSTSEGKDGSKCYTLMTDIRVIQDTMLSVSTGSTPKTNAEAVAIFFAIIDWIHAVASWHNSHFDPGQHSSGIMSSPDVVSLFESLGILLAALSGTGKGLEVLSADSHEGLKVKLGQALSAYLPLCVEVSLPLRNRLDGLQKEFNLYGERVPKSLDVPMMENMNVNALQFEASVMDGPVINSRAGLYVFINAMLVGRPLVDDGMLINYLANRYGGHYEALVEEILTASFDVLSNGMYRNESSRMMFVFRSFLVNKLPPFFAAMLASTMVSIPMEMCISHALSRLDPNTFPSFSQMFEMQGNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGYNKDELVSQINANPERAEQLINEIESMEGNAGAIIGAITEVMHNLCNQKETMTLKNICNSLSRRPQALDVVLIFRNPKQVLQPLCALLDSWHWDEDQGEYQPVYDEFGSILLLVLAFKYRFDLRPADLGISSSDSFVLRLLERGSCSQKLDALDEKQNKNLGSWIAALFIAEGISEETMSACSPQEFYLLVATLFSQSLEACETGKLEFDTLKGGFEYLLEPFLLPSLIFALTWLGDHIWEMELDPSIPLKVLHSLVNPSSISGEAREIHRTVLNIAARTLEEQLKDVRTRHPSRTDIKPILDSLEPCLSFQLVGSSHRSELEGWTTHSSGGLLGSIRSTFQSLVLWSTNPEVSMAPPPYTHRQLIAGVRMLGASRVLPALIEELKLQTEAGNGPLALDLAATLICAPMAETFSVEQNSHQPVDPNKEALPRCGILTLRDVLALQHENVPKISEKDPLRAEVLVRLYRRVNALLAPPSQVPNLDVNNIIQNMQLGGVGVGAGQMELDATGAADHGVGPDDAENIHRMIDNAAAAAGLDSSGTGLDTSIDDVLNAADMAVGNPEFLDLDMEGMF
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 5, Mediator complex subunit 5.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DSA2D_HUMAN
Sequence: MNHTVQTFFSPVNSGQPPNYEMLKEEHKVAVLGVPHNPAPPTSTVIHIRSKTSVPHHVVWSLFNTLFMNPCCLGFIAFAYSVKSRDRKMVGNVTGAQAYASTTKCLNIWALILGILMTILLIIIPVLIFQAHR
What are the official names of this protein?
Putative dispanin subfamily A member 2d, DSPA2d.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PXPA2_BRADU
Sequence: MKTIDLNCDLGEGFGAWEMGNDAAMIELASSVNVACGFHAGDPDIMRRTVELAKARGVSVGAHPGYRDLHGFGRHPIAGLKASEIENLVAYQIGALQAIATAAGHKVTHVKAHGALSNVACEDDMTAKAIAAGIKAVDPSLIFVVLANSKLVKAGEAANLPMVHEVFADRAYEDDGNLVSRKKPGAVLHDAKAIADRVVRMVQDGAVVSVTGKVIKMRTDTVCIHGDTHGAVEIARTLRQALKDAGIEVAPFKRGA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A 2, 5-OPase subunit A 2, 5-oxoprolinase (ATP-hydrolyzing) subunit A 2.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: NMI_HUMAN
Sequence: MEADKDDTQQILKEHSPDEFIKDEQNKGLIDEITKKNIQLKKEIQKLETELQEATKEFQIKEDIPETKMKFLSVETPENDSQLSNISCSFQVSSKVPYEIQKGQALITFEKEEVAQNVVSMSKHHVQIKDVNLEVTAKPVPLNSGVRFQVYVEVSKMKINVTEIPDTLREDQMRDKLELSFSKSRNGGGEVDRVDYDRQSGSAVITFVEIGVADKILKKKEYPLYINQTCHRVTVSPYTEIHLKKYQIFSGTSKRTVLLTGMEGIQMDEEIVEDLINIHFQRAKNGGGEVDVVKCSLGQPHIAYFEE
What is the function of this protein?
Acts as a signaling pathway regulator involved in innate immune system response (PubMed:9989503, PubMed:26342464, PubMed:29038465, PubMed:29350881).  In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (PubMed:9989503, PubMed:29377960).  Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (PubMed:9989503).  In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (PubMed:10779520, PubMed:10950963).  In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 (PubMed:26342464).  In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881).  Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity).  Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (PubMed:29038465).  Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465).
What are the official names of this protein?
N-myc-interactor, Nmi, N-myc and STAT interactor.
What is the protein family that this protein belongs to?
Belongs to the NMI family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Note=Cytoplasmic NMI localizes in punctate granular structures (PubMed:9781816, PubMed:10950963). Nuclear localization increased following IFN-alpha treatment (PubMed:9781816, PubMed:10950963). Extracelullar following secretion by macrophage (PubMed:29038465).
Protein: NU4C_TOBAC
Sequence: MNYFPWLTIIVVFPIFAGSLIFFLPHKGNRVIRWYTICICILELLLTTYAFCYHFQSDDPLIQLVEDYKWINFFDFHWRLGIDGLSIGPILLTGFITTLATLAAWPVTRDSRLFHFLMLAMYSGQIGSFSSRDLLLFFIMWELELIPVYLLLCMWGGKKRLYSATKFILYTAGGSVFLLMGVLGLALYGSNEPTLNFETSVNQSYPVVLEIIFYIGFFIAFAVKSPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLIRINMELLPHAHSIFSPWLMIIGTIQIIYAALTSLGQRNLKKRIAYSSVSHMGFIIIGISSLTDTGLNGALLQIISHGFIGAALFFLAGTTYDRIRLVYLDEMGGIAIPMPKMFTMFSSFSMASLALPGMSGFVAELIVFFGIITGQKYLLIPKILITFVMAIGMILTPIYSLSMSRQMFYGYKLFNAPKDSFFDSGPRELFLSISIFLPVIGIGIYPDFVLSLAVDKVEVILSNFFYR
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ATG8_NEOFI
Sequence: MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGDC
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier atg8.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor.
Protein: REX_LISIN
Sequence: MMEETTKIPQATAKRLPLYHRYLKYLDESGKERVSSAELSEAVKVDSATIRRDFSYFGALGKKGYGYNVSYILDFFSKTLSQDKQTNVALIGVGNLGTALLHYNFMKNNNIKIVAAFDVDPAKVGSVQQDIPIYHLNDMEEIVRENGVEVVILTVPADEAQVTVDRLIEADVKGILNFTPARISVPKQVRVHHIDLTTELQTLIYFLENYPAKTE
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BBE21_ARATH
Sequence: MIATQTFVSVFFFVFFLVSLPFFSSAAPPSSDSIYESFVQCFSDKTKSPQAQITDNVFSRTNPSFSSVLRAYIRNGRFNTSSTPKPAIIVTPRSDIHVSAAVTCSKSLNFLLKIRSGGHDYEGLSYISDKPFFILDMSNLRDVSVDIADQSAWISAGATLGEVYYRIWEKSKVHGFPAGVCPTVGVGGHISGGGYGNMLRKFGLSVDNLIDAKIVDVNGQILDRKSMGEDLFWAISGGGGASFGVVLGYKVKLVPVPETVTVFRVEKYMDSGAVDMVHKWQSVGPKTDRNLFLRMLIQPVTRKKVKTVRATVVALFLGRAEEVVALLGKEFPELSLKKENCSEMTWFQSALWWDNRVNPTQIDPKVFLDRNLDRANFGKRKSDYVASEIPRDGIESLFKKMTELGKIGLVFNPYGGKMAEVTVNATPFPHRSKLFKIQYSVTWQENSVEIEKGFLNQANVLYSFMTGFVSKNPRNAYLNYRDVDIGVNDHGTNSYEEGEVYGRKYFGDNFDRLVKVKTAADPDNFFRNEQSIPTVLSKA
What are the official names of this protein?
Berberine bridge enzyme-like 21, AtBBE-like 21.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Secreted, cell wall.