PharMolix/UniProtQA huggingface dataset:
Protein: RL25_RICPU
Sequence: MSEILELEAESRTEFGTGAARALRRAGRVPAIIYGAGKTPVSISLEEKEITKYYRKPAFISQLINLTIDKKKYKVLPKAVELHPVTDIVRHVDFVFLEEKTQKMEVPVVYEGKERALGVKRGGYFNIVKRRVTLLCDVNNIPRNVTIDVTNMPMATSLKSSKIELPKGCSFVTKKEFVLATIIGRRGAKTEAEGEQQAAEAGK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: HIS6_PSEPK
Sequence: MALAKRIIPCLDVDNGRVVKGVKFENIRDAGDPVEIARRYDEQGADEITFLDITASVDGRDTTLHTVERMASQVFIPLTVGGGVRTVQDIRNLLNAGADKVSINTAAVFNPEFVGEAADRFGSQCIVVAIDAKKVSGPGEAPRWEIFTHGGRKPTGLDAVEWAKKMEGLGAGEILLTSMDQDGMKNGFDLGVTRAISDALGIPVIASGGVGNLQHLADGILEGHASAVLAASIFHFGEYTVPEAKAYMASRGIVVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGN_PROMI
Sequence: MMEELRQTLDLQLSQLNTIAGILRAEQQLLCAGSIDINKLHEITEQKNFVLTALGHTDQKRQILSKQVGIDRPYQGQPFLADLWGQLVDLTEELKHLNQHNGLLLEQHITRNSETLHFLQKNHSPTLYGADGQAQRSILAGRKIQI
What is the function of this protein?
Required for the efficient initiation of filament assembly.
What are the official names of this protein?
Flagella synthesis protein FlgN.
What is the protein family that this protein belongs to?
Belongs to the FlgN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABC3H_HUMAN
Sequence: MALLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKKCHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLGIFASRLYYHWCKPQQKGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLERIKIPGVRAQGRYMDILCDAEV
What is the function of this protein?
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms.  The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1.  After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA.  The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.  Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.  Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
What are the official names of this protein?
DNA dC->dU-editing enzyme APOBEC-3H, APOBEC-related protein 10, ARP-10, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H, A3H.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
Protein: MPPE1_MACFA
Sequence: MAMIEVGFERQNFYPLKRKSALLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTAYDGEQASHEPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERALQTALWLLQPEVVFILGDVFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVAMNGDGCGICSEAEAELIEVSHRLNCSREARGSRRCGPGPLLPVSAPVLLQHYPLYRRSDANCSGDDAAPPEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPEFSVPSFSWRNRNNPSFIMGSITPTDYALSKCYLPREDVVLVIYCGAVGFLVVLTLSHLGLLASPFLSGLNLLRKRKTR
What is the function of this protein?
Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi.  Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).
What are the official names of this protein?
Metallophosphoesterase 1, Post-GPI attachment to proteins factor 5.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. MPPE1 family.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi- pass membrane protein. Note=Also localizes to endoplasmic reticulum exit site.
Protein: CBPA_SALPB
Sequence: MELKDYYAIMGVKPTDDLKTIKTAYRRLARKYHPDVSKEPDAEARFKEVAEAWEVLSDEQRRAEYDQLWQHRNDPQFNRQFQQHEGQPYNAEDFDDIFSSIFGQHGRHSHHRHAARGHDIEIEVAVFLEETLEEHQRTISYSVPVYNAFGLVEREIPKTLNVKIPAGVSNGQRIRLKGQGTPGENGGPNGDLWLVIHIAPHPLFDIVNQDLEVVLPLAPWEAALGAKVSVPTLKERILLTIPPGSQAGQRLRIKGKGLASKKHTGDLYAIIKIVMPPKPDEKTAALWQQLADAQSSFDPRQQWGKA
What is the function of this protein?
DNA-binding protein that preferentially recognizes a curved DNA sequence.  It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock.  Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK.  Its activity is inhibited by the binding of CbpM.
What are the official names of this protein?
Curved DNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL4_TRIL1
Sequence: MPTIALYNMNREKIGEVALDEQIFAAEVKEPLIHQALKVQLANRRAGTVKTKTRAEVSGGGKKPFKQKGTGNARQGCSRAPQYPGGGTVFGPQPKTYNLGINKKARKAALRSLLSMQLKSEKITVLDQIEFAKISTKDFAGFMKKFDLERSLIITEEPSTNLALSSRNVPYVKLLKADGLNVFDVLKYQNIVMTEGAVRLVEGALQ
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: COQ7_BURP0
Sequence: MVFDELITEFDRGLRSIAGVSRMSRPVPKPAAAAPAELSAAERKHAAGLMRVNHVGEVCAQALYQAQKLTTSSAGLKEMFEHAAREEEDHLAWTAHRLKDLDSRPSLLNPLWYAGALAIGVVAGRLGDKMSLGFMAETERQVESHLDGHLSELPAADVESRAIVEQMRADEVKHGKSATDAGGIELPMPARMLMRAASKVMTSTAYYL
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: C5AR2_HUMAN
Sequence: MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV
What is the function of this protein?
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively.  Couples weakly to G(i)-mediated signaling pathways.
What are the official names of this protein?
C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DUT_SALG2
Sequence: MKKIDVKILDPRVGQQFPLPTYATSGSAGLDLRACLDDAVELAPGATTLVPTGLAIHIADPSLAAVMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSIWNRGQDSFTIEPGERIAQMVFVPVVQAEFNLVEAFDATERGEGGFGHSGRK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: GLPK_ALKOO
Sequence: MKKYVMALDQGTTSSRAILFDYEGKIVATSQKEFTQIYPKAGWVEHDPMEIWGTQSGVAREVLERMAISPQDIAAIGITNQRETTIVWDKNTGKPVYNAIVWQCRRTAAICDELKTQGMADYIRENTGLVLDAYFSGTKIKWILDHVEGAKEKAEKGELLFGTVDSWLIWNLTRGKVHVTDYSNASRTMLYNIKQLKWDDKILKALEIPKSMLPEVKESSAIYGYTDHQTFGGADIPIAGAAGDQQAALFGQGCFKEGMGKNTYGTGCFMLMNTGDQFVQSKNGLLTTLAWGIDGKVEYALEGSIFVAGASVQWLRDELKIIRDAEDTEYLAKKVPNSNGVYVVPAFTGMGAPYWDMYARGAIVGLTRGAKAEHIIRATLESIAYQTRDVLEAMEQDSGIQLKSLKVDGGAAMNNFLMQFQADILSVPVDRPKITETTALGAAYLAGLAVGFWKDKNEIESKWSVDTVFEPGMDHEEKERLYKGWKRAVNRALKWEEENELDVK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: CLPS_VIBC3
Sequence: MSKNFEWISPDFDLLEKEKTAVKPPSMYHVVLNNDDYTPMDFVIEILERFFSMDIERATQVMLKVHYEGKAICGTFTAEVAETKVAQVTMYSRENEHPLLCTMEQA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: CRYAA_PHOPH
Sequence: MDIAIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRSVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVTSGMDAGHSERAIPVSREEKPSSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.  Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: GLSA_SHEPC
Sequence: MPELALLEEVVEKVRPLLGQGKVANYIPALASVDAGKLGIAVTTVDGETLGAGDYLEPFSIQSISKVFSLTLALTLYEEAEIWSRVGKEPSGHSFNSLVQVELERGKPRNPFINAGALVIADLLQSRLGAPKHRMLELVRQLSQNDKVCFDKQVADSEYQHSARNAAIAYLMKSFGNFQGDVDTVLRTYFHYCALKMNCADLSRAMLYLANRGKTVDGTELISQVQTRQLNALLATSGLYDGAGEFAYRVGMPGKSGVGGGIIAVIPGELSICVWSPELDENGNSLAGTAMLEHLSQRLGRSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: RL20_OPITP
Sequence: MARVTNSPASRKRRKKVLKYAKGYFGSKSKLYRYAKEAVQHAWQYAYDHRRKKKSDFRALWIVRVNAACRNAGISYSRFMEGLKAANIALDRKVLADLAVRDEAGFNVLVKQAQDALKTKAASAKKA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: HPRK_CLOK1
Sequence: MSVTIEDIIKDLELEVINKGKNVNEINVSDINRPGLQFSGFYNYYANERVQIVGKAEWSFLDAMQPDLRKKRLEKYFEFDNPGTIVTRGLIPHKEFLESAIKNKRWILRTNNISTRFINRLMNYLDVKLAPETRLHGVLMDVYGIGILITGESGIGKSETALELIKRGHRLVADDAVDVKQIDGVLNGTSPYITSGMIEVRGMGIIDISALYGLSSVLKTKNIGLVICLEQWKKDENYDRLGIDKEYMDILNVPVRKLKIPIRPGRNLAVIIEAAAANYRYSLVSDVTPVDVISERIQELRKEDGGDE
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: CA141_MOUSE
Sequence: MTEKILEKFDALEEKERILEAIRENNTDRHHRQRKKPLITPLLFDLHVQFGDTITPSASKIIKNKPHDLKNPKRSVSFKYKPNNSRSDLEESDLRPPILGTMINYEESKLMDHKEENLKSRPISLRYLKDKDETEYANPLPFPQLWSKHLCKKSAESSVPTPKLTNESNASKKENVSPPFTDQHESRTKKSMHSTDHSADSSTSRGKCPPKGITKESELTRNDEARKPHPVKQSIMLPLDCEDLLKNPKIKTIDLRPAVTVHTSMKQSHANPIIFYDTEYVQMLFLTKRFTPYAMKCTERNIVLEKNYEVLKVLFSDEPSAVSEPIQQKHLQVFSAEYAQKSINEKRKKKHDRLVSKKISPNTRYNLSQTFSSLSKKFVGYFDKDVTQGKSYKANRFERFSKTKPPPTRKLTTLPIKYDSKPLKNIFEIHKLNNMTPLDNLLGLRA
What are the official names of this protein?
Uncharacterized protein C1orf141 homolog.
Protein: STE20_SCHPO
Sequence: MERGTLQPRKKAPNGYGITPIVAHKTGEPVRYEVEDDLRKLKPSRTAPKPPAINTNLAEDTFSGFPLSQSRTTVSRVSLGSRQHSSSSIRKLQTNVSDVRSYDERNQKKSAFENFVSSMSSFLTGGGSSPTSSYGSGSASPRKSTVISSPFDPKHVTHVGFNYDTGEFTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQSKKYLEEGAKPPFPRESTEKPLLSVSALSSSSHLQPTSATSSSSRLYPSRPAPTPPASSSSSPLLSSQTVKTTTSNASRQPSPLVSSKSTDNIIRSHSPVLLTPQTLSTSETKHIRPNNSTPYQRRAETSTKPKAVATPQKVEAPSAPRLQKRAPRQQSNDSAVLAKLQSICNPKNPTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEVVTNNTLSEGQIAAICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGELLRHPFLKQAVPVSSLIPLIKSIHHSGK
What is the function of this protein?
MAP4K component of the MAPK pathway required for the mating pheromone response.  Phosphorylates histone H2B to form H2BS10ph (By similarity).  Phosphorylates tea1.  Required for skb1-dependent mitotic inhibitory function.  Regulates microtubule dynamics and cell polarity.
What are the official names of this protein?
Serine/threonine-protein kinase shk1/pak1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes at cell ends, septum forming regions and at the mitotic spindle.
Protein: CCD54_MACFA
Sequence: MYTLHTKRVKAAAREMWTSNVSKVRQSFKNVYHKCKIRHQDSTRYPTVTSDDCNQDDVSYDGKMNLTVVLQDVKTAQVELFSQMTDIVHAIPKVHEKTDLYQKQMEVLETRMNVNEDKQGTTTKDILSMKEDIKALKKKVTELEKQNSYSRIHCLEIPEGERGEEITELLYKLIQPATLKNTLASTDREMSSAEPEKVPSYPKSTDHLEKITISPQIKTLKKRNHQNASRNFKIAKPNIYIYPDFSTWIKLTFVHGGKWTFFLSATKLEEFIQWLLSRPTILPEEPQVITQRYCPFTGLILSLTTICLSMFNNIYGFIRSLKEEVTRL
What are the official names of this protein?
Coiled-coil domain-containing protein 54.
Protein: ATPE_NYMAL
Sequence: MTLNLCVLTPNRIIWDSEVKEIILSTNSGQIGVLPNHAPIATAIDIGILRIRLDDQWLTMALMGGFARIGNNEITILVNDAEKGSDIDPQEAQRTLEIAEANLSKAEGKRQVIEANLALRRARARVEAINAISY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: PAGP_YERE8
Sequence: MSYKHLISACIFSSLCLGQVNAVLAEDKLPPSNTSTGQHSELSVDNDNLWQRLLRNISLAWDSPNQELYIPLNTWHNRWTYDDDKIESYNERPWGIGYGKYRYDENNNWHAVYAMAFMDSHNEVEPIIGYGYQKMWIPAEMDGWRFGVGFTASITARHEYHYIPIPLPLPLISIEYNKFSLQTTYIPGTYNNGNVLFTWMRWQF
What is the function of this protein?
Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.
What are the official names of this protein?
Lipid A acyltransferase PagP, Lipid A acylation protein.
What is the protein family that this protein belongs to?
Belongs to the lipid A palmitoyltransferase family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: TIG_PELPB
Sequence: MQKNIKNVSETEQELEIILSAEEFGTEYNQELEEAKRNIQIKGFRKGHAPASLIKKLAGPSIEATVAEKMASKYFGEIADAEKIKPASRAQIIDVAFAPEELKITLAYEIHPEFEVKDFSGYTFTQNRYVITDEDITREINLILKGHGTLNTVDEAALSTDTVIGDVYKLNEAGETDDDQKTDNHHFTLEYLPEENPFRKALTGKKAGESVDIENDEKESAQPSRFRVVISEIKRLELPELTDELVKEITGGRFESVTDFTADVRIQLEQHFLLKSDEELLESLSAKLIEENPVPAPNSMIASFSKMLLENAKRQMGGSFPKGFDDEQFRLAMKPNAEKHAQWLMISQKIAEDATLSVSDDDIKAYADKEAEKSESMDAEEILKTYLSPEFRDYITDTILKEKIYNIIKSKVTITEEEKSIPVRQE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ATL42_ARATH
Sequence: MYQIFFFFLPLLHSYASAQTPPPFRNGDLVANFEPSLAVVTGVLAIMFALTFVLLVYAKCCHIDLRSGSGDRRRHDRRLRQGIFFNRSTASSDRFSGLDKTAIESLPLFRFSALKGSKQGLDCSVCLSKFESVEILRLLPKCRHAFHIGCIDQWLEQHATCPLCRDRVSMEEDSSVLTNGNSFRFLNQSEIREDSSLELYIEREEEEERIHREELSGSSRFSIGESFRKILKLGNKEKTLLDEHVNDKDEKKLMHKFNHRIVVSDVVFKNRWSNVSSSDLMFLNSEMVNSISSERFSSLDHVKRGDEEDQIGILRIKEEMEAKRMLENKLTSMTTMFSSENGDSGSKSRSVMIEPGRRSVSDITAVPRLSISIHGDCSGSAAETASALQNGGNETEERRRRLWLPIARKTAQWFANREKRSQINTTHQHFDV
What is the function of this protein?
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8 in vitro.
What are the official names of this protein?
E3 ubiquitin-protein ligase ATL42, RING-H2 finger protein ATL42, RING-type E3 ubiquitin transferase ATL42.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CRADD_PONAB
Sequence: MEARDKQVLRLLRLELGAEVLVEGLVLQYLYQEGILTENHVQEINAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQINQLAQRLGPEWEPVVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSLHNGLRAVEVDPSLLLHMLE
What is the function of this protein?
Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis.  Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.
What are the official names of this protein?
Death domain-containing protein CRADD, Caspase and RIP adapter with death domain.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TILS_METPP
Sequence: MSGSRATAATTTPRSAEPPRGLAVAYSGGRDSTALLHATLIAARDSGLTVHALHVHHGLSARADAWLAHCESQCRRWARRGLPVCFRAMRVQLACRSGDSLEAVARAARYAALRTLAVEQGVALVLLAHHQRDQAETLLLQALRGAGVAGLAGMPRSIERDGITWARPWLARPREAIEAYVRRYRLSYIDDDSNDDPRFARNRLRLQVWPALQAAFPQAEGTLADAARWAQQAAACVADLAALDLAACAATNDVLPLTAWRQLAPHRAVHALRRWLQQAGVTAPTAADLERLMAELPAGAPARWPLKGGELRRYRGELRFVPTPDATREPPAVRETTLALRRGGRYRLPGWGGVLVAERVRAGGVPAAQLAVLSLQPRRGGEQFQGEAGRPARSLKKQYQAAAVPAWARGGPLLYGGDGRLLFVPGLGVDARAMAAPGEPQLALRWEPLPTG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPRK_STRA1
Sequence: MAVTVQMLVDRLKLNVIYGDEHLLSKRITTADISRPGLEMTGYFDYYAPERLQLVGMKEWSYLMAMTGHNRYQVLREMFQKETPAIVVARDLEIPEEMYEAAKDTGIAILQSKAPTSRLSGEVSWYLDSCLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDIMSLYGASAVKDSSQVQLAIYLENFETGKVFDRLGNGNEEIELSGVKVPRIRIPVKTGRNVSVVIEAAAMNHRAKQMGFDATQTFEDRLTHLISQNEVNDD
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: RMLA_NEIMA
Sequence: MKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILVITAPEDNASFKRLLGDGSDFGISISYAVQPSPDGLAQAFIIGEEFIGNDNVCLVLGDNIFYGQSFTQTLKQAAAQTHGATVFAYQVKNPERFGVVEFNENFRAVSIEEKPQRPKSDWAVTGLYFYDNRAVEFAKQLKPSARGELEISDLNRMYLEDGSLSVQILGRGFAWLDTGTHESLHEAASFVQTVQNIQNLHIACLEEIAWRNGWLSDEKLEELARTMAKNQYGQYLLRLLKK
What is the function of this protein?
Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.
What are the official names of this protein?
Glucose-1-phosphate thymidylyltransferase, dTDP-glucose pyrophosphorylase, dTDP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the glucose-1-phosphate thymidylyltransferase family.