PharMolix/UniProtQA huggingface dataset:
Protein: Y1447_SHEB9
Sequence: MLGWTLVFLVVAVIAGLLGFTGIAGAAAGIAKIIFFVFIVLLVISLLVNAFRGKSPRL
What are the official names of this protein?
UPF0391 membrane protein Sbal195_1447.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PRS6B_MANSE
Sequence: MEEIGIILPEKDDQVTDAKGLPFAGPQTFDELESEDLYTKYKKLQRMLEFLEVQEEYIKDEQRNLKKEYLHAQEEVKRIQSVPLVIGQFLEAVDQNTGIVGSTTGSNYYVRILSTIDRELLKPSASVALHKHSNALVDVLPPEADSSISMLQADEKPDVQYSDIGGMDTQKQEIREAVELPLTHVELYRQIGIEPPRGVLMYGPPGCGKTMLANAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITAKMNLSEEVDLEEFVARPDRVSGADINAICQEAGMNAVRENRYIVLPKDFEKGYKNNIKKDESEYEFYK
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
What are the official names of this protein?
26S proteasome regulatory subunit 6B, ATPase MS73.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: UNG_ECOLU
Sequence: MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIATPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRHHVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQHGETPIDWMPVLPAESE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_RHIEC
Sequence: MADNKTENTLSSDATEVRAQKLKLLREQIGDVYPAHFHRSLTNAELATRYEGLDPDVETQDIVTVAGRVYSSRNSGMFMDIHDASGKIQIFSHKDVTGEEARALLPMIDIGDIIGVTGIVRRTKRGELTINAQKIEMLTKSLLPMPEKWHGLSDIELRYRKRHLDILTNEDSKLRFQQRSKIVSGIRRFMENDGFMEVETPMLQSIYGGATAEPFKTHHNTLKLDMYLRIAPELFLKRTLVSGLTDKVFEINRNFRNEGVSTRHNPEFTMMECYWAYADYEDMMDLVERLFETLALSIHGTTEFDFGDKRLSFKGPFKRVPMPDAVKEVTGIDFLAIKTDEEARAAAKAAGFAVEKDWTWGECLAFIFEEKVEATLIQPSHVTHFPKDISPFAKEVPGEPRLVERFETYCNAWELGNAFSELNDPEEQRRRMVEQLEQAHARGEKEKQLDEEFLDAIDQGMPPAGGLGIGVDRLIMLLTNAPSIRDVILFPARRSKAD
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFH_COXB2
Sequence: MISIIIAYATPEKQVEIPLTVEESCTLVVAVKRSGILQQFPEINLSQAIVGIHNKRTALDAGLRDGDRIEIYRPLTMDPKQARLLRAKRGKIRRMVRGEAG
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: RBFA_ACIC1
Sequence: MNDRARARKLADRIKVVVAETLERRVKDPRLGFVTITDARVTPDLREATVFYTVLGDDTALAETAAALESAKGVLRAEVGRQTQVRFTPTLTFVPDTVPRQARQIEELLARARAADREVAERAKSAQPAGEPDPYRFDGAAAADDDEPAT
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_RHDSA
Sequence: MSSTKLSTSILPDLVEIQRASFCWFLEEGLAEEIKSFSPITDYTGNLELHFFGDQFKLKCPKYNLLESKRRDATYSVQVYVPARLINRDTGIIKEQEVFIGDLPLMTDRGTFIINGAERVIVNQIVRSPGIYYKSETDRQGRRTYSGSLISNRGAWVKFETDRNDLVWVRIDKTRKIPAHVFLKAMGLSDSDIYNGLRHPEYLKKSFRVEGNYTTEEALIQMYTKLRPGEPATVNGGQQILYSRFFDPKRYDLGKVGRYKINKKLALSIPENIKVLTPQDTLSAIDYLINLKFNIGETDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIRERMTICDSESLAPNTLVNPKPIIAAIREFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLNRDRAGFAVRDIHPSHYGRICPIETPEGPNAGLIGVLATHARINSYGFIETPFYQVINGKVVSDGNPVYLTADQEDNFRIAPGDIAIDENNAINNDIVPVRYRQEFTITKPEQIDYIQVSPIQVISIATSLIPFLEHDDANRALMGSNMQRQAVPLLYPESPLIGTGIEAQAARDSGMVVVSYQDGRVTYVSANKICITDDEGKEVVYYLQKYQRSNQDTCINQRPSVWLGEKVVAGQVIADGAATEGGELALGQNILIAYLPWEGYNYEDAFLISERLVYNDVYTSVHIEKYEIEARQTKLGSEEITRELPNIGEYSLRKLDDNGIIVIGSWVEVGDILVGKVTPKGESDQPPEGKLLRAIFGEKARDVRDTSLRVPNGGRGRVLDVRIFTREKGDELPTGANIVIRVYVAQTRKIQVGDKMAGRHGNKGIISRILPRQDMPYLPDGTPVDLVLNPLGVPSRMNVGQIFECLLGLAAENLDKRFKIIPFDEMNGAEASRVLVNEKLMEARTLTEKDWIFDLRHPGKTQLFDGRTGEAFDNPVTVGISYMLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQHGGQRLGEMEVWALEAFGASYTLQELLTVKSDDMQGRNETLNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIGAYKIENLPDGQTRGIEVDLMSNLHNRRVPSRPTYESITREDLENSFA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PIMT1_SYNFM
Sequence: MINFQKARDRMVETQLVSRGIHDRRVLEAMRKVPRHLFVDEALKEQAHSDHPLPIGDKQTISQPYIVALMTQSLELQGHEKILEIGTGSGYQAAVLAELAERVFSIERNPNLAYRANQTLQKLGYKNIIVRVADGTLGWPDEAPFDAILVTAGTPKIPQPLLDQLAEGGRLVVPVGDRLAQELVLVESGPEGMKHTNLGGVRFVDLVGKWGWEG
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase 1, L-isoaspartyl protein carboxyl methyltransferase 1, Protein L-isoaspartyl methyltransferase 1, Protein-beta-aspartate methyltransferase 1, PIMT 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_MARMS
Sequence: MKSSELRQSFLSYFESKQHQIVESSSLVPGNDPTLLFTNAGMVQFKDVFLGEDIRPYSRATTSQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKKDAIHYAWEFLTVVLKLPTEKLLVTVYADDDEAFDIWNKDIGLPVEKIIRIGDNKGGRYQSDNFWAMGDTGPCGPCTEVFYDHGEHIWGGPPGSPEEDGDRFIEIWNVVFMQFNRSADGTMASLPKPSVDTGMGLERIAAILQGVHSNYEIDLFQNLIKAAAQVVGTQDLSAQSLRVIADHIRSCSFMIVDGVIPSNEGRGYVLRRIIRRAIRHGNKLGQKGVFFHKLVEALDVEMGEAYPELTKLKERVAAILLKEEEQFAKTLDQGMKILEEAISGLGDQKVIPGETVFKLYDTYGFPADLTNDVARENGLEIDEAGFEVAMDAQRARARSASNFSMDMSGSVSVDGATEFTGYSNLNGQSAVEQIIVEGESVSSLQAGQTGLVVLAETPFYGESGGQVGDQGWLRGPAAAKVTNTTKQGKVHLHHVDVREGTLAVGDLVTTEVDRSLRNATALNHSATHLLHEALRRVLGDHVQQKGSLVNPERLRFDFSHFEGMTAAEFEQVEDMVNEQVRLNHEVVTEVMDIDSAKAKGAQALFGEKYESQVRVLTMGADYSIELCGGTHVSRTGDIGLFKIVSEGGIASGVRRIEALTGKAAIDATRHTETALGKIAGLFKASKEAALDKVVALNDQARALQKELDVLKGKMAALAGADLASQAVDINGGKLLVAQVEVEDPKALRDLLDELKSKLESAVILLAAVNDGKVSLIAGVTKELTKNVKAGDLIKMVAPYVDGKGGGRPDMAQAGGNNPEGLSAALELVPGWVAERV
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_ANADE
Sequence: MLDLSLPSGLRDLLPDHSAHLAELSSKLHDVFSRFGYRRVFLPTLERLDVVERGLSPAALADVMKFVEPGSGEVVAIRPDITPQIARLYAARPDALPSPARLCYDGPVLRAREARAGRPREVYQAGVELLGAGGASADAEALVLLARSLERVGLKAPRVEVGHARFAEAVMEAARLPQRLRSAAWEALSRKDRAALGAAAAKGRGSSEAREAVPQLAGLFGDGALDRARAIARAVPGAAAPLAETEAALRIARRRGVREVAVDLGEARGLGYYTGITFAGYAPGAGAAVARGGRYDGLLARFGRPGPAIGFAVDLEFATQALERANGRGRGVRPRRASARGGRAGTRPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPT35_YEAST
Sequence: MSDKISFLPPEPIQLLDEDSTEPELDIDSQQENEGPISASNSNDSTSHSNDCGATITRTRPRRSSSINANFSFQKAHVSDCTIVNGDHGTKFAVWRITVFLEPNLKAFAAKRESYKIQTYKRYSDFVRLRENLLTRIKTAKPEKLNCLQIPHLPPSVQWYSSWKYQEVNLNKDWLAKRQRGLEYFLNHIILNSSLVEMTKDILIQFLEPSKRVA
What is the function of this protein?
Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
What are the official names of this protein?
Endosomal/vacuolar adapter protein YPT35, PX domain-containing protein YPT35.
What is the protein family that this protein belongs to?
Belongs to the YPT35 family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=Localizes to nuclear envelope-vacuole contact sites during respiration.
Protein: SYS_BRUSI
Sequence: MLDIKWIRENPETLDKALAKRGAAPLSSELIALDEKRREHVGKVQAAQERRNAASKEIGKAMAAKDMGTAEKLKAEVGELKDFLAHAEEDERRLSKELSDALSTIPNIPLDDVPLGKDESDNVELRRIGNPHNFSFQPKEHFELGEALGYMDFERAAKLAGARFTVLKGPLARLERALGQFMLDLHTTEHGYTEVMPPLMVRDEAVYGTGQLPKFSEDLFRTTDGRWLIPTAEVPLTNLVAEEIVDMKGLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFLKVEMVSITDAESSVAEHERMTACAEEVLKRLGLPFRTVVLCTGDMGFGAQRTYDIEVWLPGQNTYREISSCSTCGDFQGRRMNARYRPEGEKSTRFVHTLNGSGVAVGRALIAVMENYQQEDGSIHIPEALQPYIGGLTRIEKAA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICS1_CAMIR
Sequence: MGKVNEVLFMNRGEGEISYAQNSAFTQKVASMAMPALENAVETLFSKDFHLLQALTAADLGCAAGPNTFAVISTIKRMMEKKCRELYCQTLELQVYLNDLFGNDFNTLFKGLSSEVVGNKCEEVSCYVMGVPGSFHGRLFPRNSLHLVHSSYSVHWLTQAPKGLTSREGLALNKGKIYISKTSPPVVKEAYLSQFHEDFTMFLNARSQEVVPNGCMVLILHGRQSSDPSEMESCFTWELLAIAIAELVSQGLIDEDKLDTFNVPSYWPSLEEVKDIVERDGSFTIDHLEGFELDSLEMQENDKWVRGDKFAKMVRAFTEPIISNQFGHEIMDKLYDKFTHILVSDLEAELPKTTSIILVLSKIVG
What is the function of this protein?
Involved in the biosynthesis of caffeine (PubMed:16333668).  Catalyzes the conversion of 7-methylxanthine (7mX) to theobromine, to some extent, able to convert paraxanthine to caffeine and, slightly, mediates the conversion of theobromine to caffeine (PubMed:16333668).
What are the official names of this protein?
7-methylxanthine methyltransferase ICS1, TCS1b, Theobromine synthase ICS1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
Protein: RK36_OENEH
Sequence: MKIRASVRKICTKCRLIRRRGRIIVICSNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y1819_LISIN
Sequence: MNLETPSQENLDFMLAEITTKLKMVNVGVFENLELDSVDYNALTDIYQLIKRKSNFSPREMQLFAEELRRIRK
What are the official names of this protein?
UPF0435 protein lin1819.
What is the protein family that this protein belongs to?
Belongs to the UPF0435 family.
Protein: ODAM_PANTR
Sequence: MKIIILLGFLGATLSAPLIPQRLTSASNSNELLLNLNNGQLLPLQLQGPLNSWIPPFSGILQQQQQAQIPGLSQFSLSALDQFAGLLPNQIPFPGQASFAQGAQAGHVDPLQLQTPPQTQPGPSHVMPYVFSFKMPQEQGQMFQYYPVYMLLPWEQPQQTVPRSPQQTRQQQYEEQIPFYAQFGYIPQLAEPATSGGQQQLAFDPQLGTAPEIAVMSTGEEIPYLGKEAINFRHDSAGVFMPSTSPKPSTTNAFTSAVDQTITPELPEEKDKTDSLREP
What is the function of this protein?
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth.  May be incorporated in the enamel matrix at the end of mineralization process.  Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK.  Plays a role in attachment of the junctional epithelium to the tooth surface.
What are the official names of this protein?
Odontogenic ameloblast-associated protein, Apin.
What is the protein family that this protein belongs to?
Belongs to the ODAM family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Nucleus.
Protein: SYE_NEIG2
Sequence: MTVKTRFAPSPTGYLHIGGVRTALFSWAFARHHKGEFLLRIEDTDLARSTAESVNIILDGMKWVGLDYDNADNVVYQTRRFDRYKEVIAELLAKGDAYYCYCSKEELEAMREKAEKEGTATYDRRWRPEAGKTLPEIPAGVQPVVRFKTPLDGVTKWTDLVKGEISIPNEALDDLIIARADGTPTYNFCAVVDDYDMGVTHIIRGDDHVNNTPKQINILKAIGANLPEYGHLPMILNEQGKKISKRSGDTVAITDFGAMGILPEAMLNYLARLGWAHGDDEFFTTEQFIEWFDLKDVSPSPSRMDLKKLYWINGEHIKITPDGKLTELVKPRLALRDIHETEKPALEDVLALVKDRAQDLNALADECLYFYKKQVPAEADVAKHWDDEAAARMLRFAERLEGLEDWNAKAIHDLFKPFCDEEGIKMGKLGMPLRLAVCGTAKTPSVDAVLALISKEEVLKRIRA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_PORG3
Sequence: MKADPIEILVSNDDGFRAQGIRELAEALRPLGNVTIVAPDGPRSGASAAITSTLPIKLKLRHREEGYTVYSCTGTPVDCVKLAMNTVFKERKPDLLVTGVNHGNNAGICVIYSGTVGAAMEGCVCDVPALAVSLDDHSEICDMSHATAYAVHVSRMILKNGLPQDTMLSMNVPKGKPLGLKPCAVTDGRFVDEYMASEDARGNAVYWMTGRQINKGTIEGDLELMHAGYVTLSPIKLNMTSRRYLPVLEELLKRSV
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_GEMAT
Sequence: MTASSGTPPHQTVERARELREQLGTAQHEYYVLDRPTLSDQEYDRLFRELQGIEAEYPTLCTEDSPTRRVGAPVQSAFSPHRHLVRMLSLDNAFDLSELEDFEQSLKRVVGDAIHTSGYTVELKIDGAAVALTYREGVLVTAATRGDGTDGEDVTANVRTIRGVPLRLHGDNHPPLMEVRGEVYLPFAGFERMNEARVAAGEPVYVNPRNAAAGSMRQLDSANTAARPLRFFGYAAVLPDGSAPARSQWELLEQLSAWGVPVAPHRQRCHTIQEAEAWATVVEHETRATLGFAIDGGVVKVNDMALQDELGIRADRTPRWGVARKFAPDMALTKLRRIDVNVGRTGVLTPFAVLEPVDVGGATVTFASLHNADQIAAKDLREGDTVQVVRAGDVIPYVLGPVPEQRDGSQQPWSMPTQCPRCNTPVERYGDDVAVYCPNVACPGRQLEGLVHFSSKDALDIDGLSYARIQQLLDAGLVHDVADLFDITVDQLTSLERFAKKSAENLVAAIAAAKQQPLSRLMFGLGIRHVGAQAAQLLSRQYGSLDALMNATAEQLGAVRGIGSIIAQSVASYFADPTTRALMERLRARGLRFDEPNAVQADGVLTGATVVLTGTLPSLSRGEATALVEQAGGRVTSSVSKKTTFVVAGEEAGSKLDKAKELGVTVLTEAELLEKLSGASADASADASA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: VE2_HPV45
Sequence: MKMQTPKESLSERLSALQDKILDHYENDSKDINSQISYWQLIRLENAILFTAREHGITKLNHQVVPPINISKSKAHKAIELQMALKGLAQSKYNNEEWTLQDTCEELWNTEPSQCFKKGGKTVHVYFDGNKDNCMNYVVWDSIYYITETGIWDKTAACVSYWGVYYIKDGDTTYYVQFKSECEKYGNSNTWEVQYGGNVIDCNDSMCSTSDDTVSATQIVRQLQHASTSTPKTASVGTPKPHIQTPATKRPRQCGLTEQHHGRVNTHVHNPLLCSSTSNNKRRKVCSGNTTPIIHLKGDKNSLKCLRYRLRKYADHYSEISSTWHWTGCNKNTGILTVTYNSEVQRNTFLDVVTIPNSVQISVGYMTI
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: YP135_YEAST
Sequence: MAEPHPKVLNLTSSITPVESLTLICNLITSPHAGAPTRPVPTLGNFLSNEPTFLGCV
What are the official names of this protein?
Putative uncharacterized protein YPL135C-A.
Protein: ATPG_HAEDU
Sequence: MAGAKEIRTKIASVRNTQKITKAMEMVATSKMRKTQERMAAGRPYSETIRKVISHIAKGSIGYKHPFLIERDVKKVGYLVISTDRGLCGGLNINLFKTTLNEFKAWKDKDVSVELGLVGSKGVSFYQSIGLKVRAHITGLGDSPEMERIVGAVNEMINAYRNGEVDMVCIAYNRFENTMSQKTVIAQLLPLPKLENDELETKCSWDYLYEPNPQVLLDSLLIRYLETQVYQAVVDNLASEQAARMVAMKAATDNAGALIDELQLVYNKARQASITNELNEIVAGAAAI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DTD_BURM1
Sequence: MIALIQRVKRADVRVGERVTGEIGAGLLALVCAERGDTEAAADKLLAKVLGYRVFSDAAGKMNLPVSNIDGAGRAGGLLLVSQFTLAADTNSGLRPSFTPAAPPDEGARLFDYFVAAARARHPIVETGEFGADMQVSLVNDGPVTFWLQVRP
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_STAA3
Sequence: MLLEKAYRIKKNADFQRIYKKGHSVANRQFVVYTCNNKEIDHFRLGISVSKKLGNAVLRNKIKRAIRENFKVHKSHILAKDIIVIARQPAKDMTTLQIQNSLEHVLKIAKVFNKKIK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: PROC_BOVIN
Sequence: XTSLLLFVTIWGISSTPAPPDSVFSSSQRAHQVLRIRKRANSFLEELRPGNVERECSEEVCEFEEAREIFQNTEDTMAFWSFYSDGDQCEDRPSGSPCDLPCCGRGKCIDGLGGFRCDCAEGWEGRFCLHEVRFSNCSAENGGCAHYCMEEEGRRHCSCAPGYRLEDDHQLCVSKVTFPCGRLGKRMEKKRKTLKRDTNQVDQKDQLDPRIVDGQEAGWGESPWQAVLLDSKKKLVCGAVLIHVSWVLTVAHCLDSRKKLIVRLGEYDMRRWESWEVDLDIKEVIIHPNYTKSTSDNDIALLRLAKPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDETKRNRTFVLSFIKVPVVPYNACVHAMENKISENMLCAGILGDPRDACEGDSGGPMVTFFRGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAQEAPLESQVP
What is the function of this protein?
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.  Exerts a protective effect on the endothelial cell barrier function.
What are the official names of this protein?
Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted. Golgi apparatus. Endoplasmic reticulum.
Protein: NDC1_DROME
Sequence: MSASSSSNACKLLLLGRCLRAVLLSVAIQFLLLTVFLLFVNFQLLHPLAWVTGTLRLVASWYTWFASIPLVASVVLYGVILCQQHLSERRYCPTRYRWLLHYGPRKVLFLFAHLLVGLLTAWLYTGYLHTDYQHLKYKCYGQDCISAYNVYLLGIGMTAGCYYFVSVHMRKEISIEFPIVEQSRAEKMRELLYASLAKSLLSSLLPTISYTAVFCLFGPMVCHRLSHILSVDMDERLDGFFGVVTNVRLLFYGYLLTAQILSNMHLMRCFYGILLSEDLPLVVTKPRAAFAHEQDITLVAGLGVFNVYVVQCLAAHHFYKLALRKNSPQRAEIFQLTEPGNRPASWRSLCDQCLSILGSFTEELTESMQKISILKCAQSLPMPKITESLTTSLMAEKVLLRQYNQKHGIRPIVSPSREVAVESPADGIRHFPNWCERVSTQLEQSLQRLLQRVPGIVYLFNEPEGAKTTFLLANSLPVVYMTQALAQVCAASLKEDPYGVVQNDLPAIIKAINKLRNELDKLSSVIGNIRISSSSFNVLRCAVRRSLYAICLSFCDYLDDLLPPGEELRQLQDLVCQE
What is the function of this protein?
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope.
What are the official names of this protein?
Nucleoporin Ndc1.
What is the protein family that this protein belongs to?
Belongs to the NDC1 family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.
Protein: ACPS_NEIMB
Sequence: MIYGIGTDIVSLKRIIRLNKKFGQAFAGRILTPEELLEFPQAGKPVNYLAKRFAAKEAFAKAVGTGIRGAVSFRNIGIGHDALGKPEFFYGPALSKWLEEQGISRVSLSMSDEEDTVLAFVVAEK
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE1_PSESM
Sequence: MKISRQAYADMFGPTVGDKVRLADTELWIEVEKDFTTYGEEVKFGGGKVIRDGMGQGQLLAADVVDTLITNALIIDHWGIVKADVGIKNGRIAAIGKAGNPDIQPDVTIAVGAATEVIAGEGMILTAGGVDTHIHFICPQQIEEALMSGVTTMIGGGTGPATGTNATTVTPGPWHMARMLQASDSFPMNIGFTGKGNVSLPGPLIEQVKAGAIGLKLHEDWGTTPAAIDNCLSVADEYDVQVAIHTDTLNESGFVETTLAAFKNRTIHTYHTEGAGGGHAPDIIKACGSPNVLPSSTNPTRPFTRNTIDEHLDMLMVCHHLDPSIAEDVAFAESRIRRETIAAEDILHDLGAFSMLSSDSQAMGRVGEVIMRTWQTADKMKKQRGPLPQDGPGNDNFRAKRYIAKYTINPAITHGISHEVGSIEVGKWADLVLWRPAFFGVKPTLILKGGAIAASLMGDANASIPTPQPVHYRPMFASFGSSLHATSLTFISQAAFDAGVPETLGLKKQIGVVKGCRTVQKKDLIHNDYLPDIEVDPQTYQVKADGVLLWCEPADVLPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.