PharMolix/UniProtQA huggingface dataset:
Protein: TOCA2_CAEEL
Sequence: MIPVSRFFTVQDPSNALLSYTQKGIDFFEKLGQFSKEKAAIEEEYSTKLRSLAKKYAKKSEEDDEILKSVSYTSSFNSFLQQLDQIATRHQTSAEHIRGGVVSYVASKTCQMRSSRKNAINDLKTINDKLEDQINEMCKSGKCYLKSFKDAENSYQKFYKADKNLEISRLELEKARALANARNEACELAKQDYSALVRKTNAEQKRYHVELLPVIFARLKAVDKECIADMRQVLQKIVSFDDSLADSTEECRKIMQREVGKIDAEGDAQLVLKSVEATIEQPAPFEIEDLGDPKNCDSRTNDSADGSGGKLLKSSPSKNRIIRNFLGILKEKEADEKPEASNNDQLMYTDKSKPAHVRLSCLRSKIRDMEKQLEQAIQGREGITRLQQAYYTNPQHGNPSACTEPLISYAKKIEKLKMDIHNLKEFYAMLEMSVEEGQERSFGGRDTPDTTRSMSGSSTNQSSSKTIEDVLSGEAGNSSSADDSSKNILRQLFTTPKRLISSPKTSKSSTPTPLRRRAEISSPKILRSSFSGAIRKSLSTPDSVKVETAVTVTALFEFAKSSAETMSIEQGEILLVLEHDHGDGWTRTKNCRKHNEESGFVPTSYLQFPQ
What is the function of this protein?
Plays a role in protein trafficking, actin organization and embryonic morphogenesis (PubMed:19798448).  Potentially acts as cdc-42 effector (PubMed:25775511).  May play a role in egg laying (PubMed:19798448).  Together with toca-1, is required for protein trafficking regulating yolk protein clathrin-mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14 (PubMed:19798448, PubMed:25775511).  Also, together with toca-2, controls the distribution of actin at cell junctions (PubMed:19798448, PubMed:26578656).
What are the official names of this protein?
Transducer of Cdc42-dependent actin assembly protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the FNBP1 family.
What are the subcellular locations of this protein?
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Recycling endosome. Note=Diffuse cytoplasmic localization (PubMed:19798448). Localizes to the rachis, which is the central core of the cytoplasm connecting developing oocytes in the syncytial gonad (PubMed:19798448). Co-localizes with toca-1 on recycling endosomes (PubMed:25775511).
Protein: Y3297_STRCO
Sequence: MLVLRSAALFVVAALFEIGGAWLVWQGVREQRGWLWAAGGVLALGAYGFVATFQPDAHFGRILAAYGGIFVTGSILWGVVADGYRPDRWDIAGALVCLAGMALIMWAPRNGG
What are the official names of this protein?
UPF0060 membrane protein SCO3297.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TNNT3_PIG
Sequence: MSDEEVEHVEEEYEEEEEAQEEAPPPPAEVHEVHEEVHEVHEPEEVQEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEEAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDALYQLEIDKFEYGEKLKRQKYDIINLRSRIDQAQKHSKKAGTTPKGKVGGRWK
What is the function of this protein?
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
What are the official names of this protein?
Troponin T, fast skeletal muscle, TnTf.
What is the protein family that this protein belongs to?
Belongs to the troponin T family.
Protein: LEXA_SALPA
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVLEIVSGASRGIRLLQEEEDGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPSADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFTPIVVDLREQSFTIEGLAVGVIRNGEWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RPOA_ECOLI
Sequence: MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
What is the function of this protein?
Part of the processive rRNA transcription and antitermination complex (rrnTAC).  The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNAP.  It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: CLSA_SALPK
Sequence: MTTFYTVVSWLVILGYWVLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAQENSSVASSLFKLCERRQGIAGVKGNQLQLLTDSDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRDIHCRLMLDSAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSMNMVDPRFFKQDAGVGQWVDLMARMEGPVATAMGIVYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTATYAAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSLLVGWASRAFFSELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLVIDDTGFGADLAAVQDDYISRSRLLDARLWVKRPLWQRITERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PARK7_CHICK
Sequence: MASKRALVILAKGAEEMETVIPTDVMRRAGIKVTVAGLTGKEPVQCSRDVLICPDASLEDARKEGPYDVIVLPGGNLGAQNLSESAAVKDILKDQESRKGLIAAICAGPTALLAHGIGFGSKVITHPLAKDKMMNGAHYCYSESRVEKDGNILTSRGPGTSFEFGLAIVEALMGKEVAEQVKAPLILKD
What is the function of this protein?
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals.  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals.  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage.  Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA.  Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair.  Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity.  Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease.  It is involved in neuroprotective mechanisms as well as cell growth and transformation.  Its involvement in protein repair could also explain other unrelated functions.  Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death.  Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria.  Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells.  Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress.  Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (By similarity).
What are the official names of this protein?
Protein/nucleic acid deglycase DJ-1, Maillard deglycase, Parkinson disease protein 7 homolog, Parkinsonism-associated deglycase, Protein DJ-1, DJ-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cytoplasm. Nucleus. Membrane raft. Mitochondrion. Endoplasmic reticulum.
Protein: RCN3_RAT
Sequence: MMWRWTLMLLLLLLRHWALGKPSPDAGPHGQDRVHHGTPLSEAPHDDAHGNFQYDHEAFLGRDVAKEFDQLTPEESQARLGRIVDRMDLAGDSDGWVSLAELRAWIAHTQQRHIRDSVSAAWHTYDTDRDGRVGWEELRNATYGHYEPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVVAETLEDLDKNKDGYVQVEEYIADLYSAEPGEEEPAWVQTERQQFRDFRDLNKDGRLDGSEVGYWVLPPSQDQPLVEANHLLHESDTDKDGRLSKAEILSNWNMFVGSQATNYGEDLTRHHDEL
What is the function of this protein?
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (By similarity).  Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity).  By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity).  Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity).  This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity).
What are the official names of this protein?
Reticulocalbin-3.
What is the protein family that this protein belongs to?
Belongs to the CREC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: CCA_PSEE4
Sequence: MQIYKVGGAVRDRLLGRPVSDVDWLVVGATVEQMQAQGFRPVGADFPVFLHPKTGEEYALARTERKSGRGYGGFTFHASPDVTLEEDLIRRDLTINAMAEDEHGDLHDPYHGKTDLDQRILRHVSLAFAEDPLRVLRVARFAARYAPMGFRVADETLELMRQISASGELLALTAERSWKEIERALMEDQPQVFIEVLRACGALKELMPEVDALFHGEVSQGSHALDVLQQAAAQQQPLAVRWACLLLALGGKQIKTVNQRFKAPRECQELAILVGEFHEQGHRAMELAPEMLLDLLQKFDVYRRPQRFEEFIEACRMDALLGGRDYPQSEYLRGAAATARAVDVKPLMESGLTGQALGGALKAARLSALQAYKAR
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 2 subfamily.
Protein: RL2_KINRD
Sequence: MGIRKYKPTTPGRRGSSVADFVEITRSEPEKSLVRPLSKTGGRNSSGRITTRHIGGGHKRAYRLIDFRRHDKDGVPAKVAHIEYDPNRTARIALLHYVDGEKRYIIAPAKLKQGDRIENGPEADIKPGNNLPLRNIPVGTVIHAIEIRPGGGAKIARSAGASVQLVAREGRFAQLRMPSGEIRNVDVRCRATIGEVGNAEQSNINWGKAGRMRWKGKRPTVRGVAMNPIDHPHGGGEGKTSGGRHPVSPWGQPEGRTRRPGKESDKLIVRRRRTGKKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: INO1_TRYBB
Sequence: MPAVRTKSGHGVEYTDEAITATYSYNTTRVEKEANGDVTVQPIQLHLKFRTQRKVQRTGVMLIGWGGNNGTTVTAALMAHKHRXSWRTKTGTKQPDYLGSITQSSTMSVGLTSEMEEVFVPMKALVPMINPAELVIGGWDCSGMNIADAMRRAQVLDVTLQDALYNYLKDMHPLPAAFDLDFVAENQLSRADNIMQTKNKWESVEQLRADIRNFREKNSLEEVIVLWTANTERFSEHITGVHDTADHLIDAIRRNENEIAPSVLYATAAIMEGCSYVNGAPQNTLCAGLIELARRHGVFVVGDDFKSGQTKVKSGLVEFFMDAGIKPECIASYNHLGNNDGYNLAAPKQFRSKEVTKGGVLDDMVSSNSILYPPGSRGPDHCIVIKYLPYVGDSKRALDEYNFSIFMGGEQTVVLHNTCQDSLLAAPLIIDLVVLTELMHRVTVTQCDGEDCCDKKEKMTSYTHMETVLSLLSYLLKAPRVPEGTPVVNGLNRQGQAIKNVLRALVGLPPDNNMQLECRLPFLRGVGS
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:16824097, PubMed:16246027).  Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).  De novo-synthesized myo-inositol is essential for incorporation into GPI (glycosylphosphatidylinositol) glycolipids in the bloodstream form (PubMed:16246027).
What are the official names of this protein?
Inositol-3-phosphate synthase, Myo-inositol-1-phosphate synthase, MIP synthase, TbINO1.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
Protein: CLIC1_PIG
Sequence: MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDI
What is the function of this protein?
Can insert into membranes and form chloride ion channels.  Channel activity depends on the pH.  Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity).
What are the official names of this protein?
Chloride intracellular channel protein 1, Nuclear chloride ion channel 27.
What is the protein family that this protein belongs to?
Belongs to the chloride channel CLIC family.
What are the subcellular locations of this protein?
Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).
Protein: ETHD_METRA
Sequence: MAISDSVSPEPQQLLCLTITAFRKPGMSEAAYREYMTKTHAPLVSGLMEEYGIVRYNMTHNNSKSRPLLFQLYDPEFSKLSDYDCIVQFVFRRMEDFLRMKSDPRFLEKVAPDHQKFADTSRSTMTIGYFEEFLENGKVVPK
What is the function of this protein?
Dehydratase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:28447400).  The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (Probable).  The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (Probable).
What are the official names of this protein?
Conidial pigment biosynthesis dehydratase EthD.
What is the protein family that this protein belongs to?
Belongs to the tpcK family.
Protein: ISPH_CHLTE
Sequence: MKINLDRTSSGFCIGVQGTIHVAEEKLAQSGELYCLGDVVHNEVEVKRLEALGMETIDIPAFEELRNAEVLIRAHGEPPSTYETARKNNLAITDTTCPVVAKLQRTAKMLHQLGYQVVIYGKKVHPEVIGINGQCDDEGVVIKHPDLSDPEEIAPLDLSRKTALISQTTMDVPGFYELKRNLEKLFAEHGHRNPGTQSGEWMAVRDIDITAEKTGALAMPKLVFKDTICRQVSSRNGKLRDFALANDCIVFAAGRKSSNGQVLYSICKDANPHSYFIEDVDEIRPEWFVGENGKPVESVGICGATSTPMWLLEKVANYIDKTFGDGSSNPNA
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: PLD6_XENTR
Sequence: MLLWGRWKVVAGLAGLALSLELLLRYMRRRKPIREVLFFPAPVTCIEPVLYPMKQCSCPLPHTDSAFSRLLLLLLRAQRSLELCVFTFSCPSLARAVLLLHSRGVRVRVITDNDYMAASGSQIGPLRSAGVAVRHDQSSGYMHHKFAVVDGTVVLTGSLNWTVQATQTNRENILITDDRVIVKAYQQEFERLWQEYDPASYDFFPEKENK
What is the function of this protein?
Presents phospholipase and nuclease activities, depending on the different physiological conditions.  Plays a key role in mitochondrial fusion and fission via its phospholipase activity.  In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid.  Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission.  Regulates mitochondrial shape through facilitating mitochondrial fusion.  During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity).  piRNAs provide essential protection against the activity of mobile genetic elements.  piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation.  Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity).  Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity).  Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface.  Although it cannot be excluded that it can act as a phospholipase in some circumstances, this activity could not be confirmed (By similarity).
What are the official names of this protein?
Mitochondrial cardiolipin hydrolase, Choline phosphatase 6, Mitochondrial phospholipase, MitoPLD, Phosphatidylcholine-hydrolyzing phospholipase D6, Phospholipase D6, PLD 6.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: MNMG_BORBZ
Sequence: MDFDAIVIGGGHAGIEAALALSRLNFKTLMITQNLDTIGKLSCNPAIGGLAKGNMVREIDALGGEMGRIIDFSMIQFRVLNKSRGPAVQAPRAQADKLMYQTKAKETLERQDNLDLFQDTVVDFLLNSMRNEIEGVVTERGNKFRSSVVVLTTGTFLRGKIFIGEYRADMGRLAEFSAYGLDKTLLGLGFEMGRLKTGTPARIHKKSVDFSKTEVQFGDSDIIPFSFSNGKLDKSQLSCYVTYTNKKTHEIISENMHLSPLYSGEIVGNGPRYCPSIEDKIVKFKDKDRHQIFIEPEGFNTEEMYLNGLSSSLPENIQQKLINSIEGLEHAVITRPGYAVEYDYINPIELYPNLESKRVKGLFIAGQTNGSSGYEEAAAQGLMAGINAALRLQNKKPMILTRTSSYIGVLIDDLVTKGTKEPYRMFTSRAEHRLNLRHDTSDKRLIKIGYDLGLVDEKRYSRYLFKESRVEEIKELLKQRRLSLKDVVDEQLKKHVSKDFYHILKDPSISLDNLIKIDPSLSDSKVILEQVELDVKYEGYINRQKDLIKRLDNLELVKLPFDFNYEIIEGLSREAREKFSKIQPATLAQASRIPGIRSTDITVLLIYFSNPKNKVVINFSL
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STL1_YEAST
Sequence: MKDLKLSNFKGKFISRTSHWGLTGKKLRYFITIASMTGFSLFGYDQGLMASLITGKQFNYEFPATKENGDHDRHATVVQGATTSCYELGCFAGSLFVMFCGERIGRKPLILMGSVITIIGAVISTCAFRGYWALGQFIIGRVVTGVGTGLNTSTIPVWQSEMSKAENRGLLVNLEGSTIAFGTMIAYWIDFGLSYTNSSVQWRFPVSMQIVFALFLLAFMIKLPESPRWLISQSRTEEARYLVGTLDDADPNDEEVITEVAMLHDAVNRTKHEKHSLSSLFSRGRSQNLQRALIAASTQFFQQFTGCNAAIYYSTVLFNKTIKLDYRLSMIIGGVFATIYALSTIGSFFLIEKLGRRKLFLLGATGQAVSFTITFACLVKENKENARGAAVGLFLFITFFGLSLLSLPWIYPPEIASMKVRASTNAFSTCTNWLCNFAVVMFTPIFIGQSGWGCYLFFAVMNYLYIPVIFFFYPETAGRSLEEIDIIFAKAYEDGTQPWRVANHLPKLSLQEVEDHANALGSYDDEMEKEDFGEDRVEDTYNQINGDNSSSSSNIKNEDTVNDKANFEG
What are the official names of this protein?
Sugar transporter STL1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NU4C_AETGR
Sequence: MNYFPWLTIIVVFPISAGSLMLFLPYRGNKVHKWYTICICILELLLTTYTFCYNFKMNDPLIQLSEDYKWINFLDFYWRLGIDGLSIGTILLTGFITTLAILAAFPVTRDSRLFHFLMLAMYSGQIGSFSSQDLLLFFIMWELELIPVYLLLSMWGGKKRLYSATKFILYTAGSSIFLLIGVLGISLYGSNEPTLNLELLANQSYPVTLEIILYIGFLIAFAVKSPLIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLVRINMELLPHAHSMFSPWLMVVGTIQIIYAASTSPGQRNLKKRIAYSSVSHMGFIIIGIASITDPGLNGAILQIISHGFIGAALFFLAGTSYDRIRLVSLDEMGGMAISIPKIFTMFTILSMASLALPGMSGFVAEFIVFFGIITSQKYLLMAKILIIFVMAIGMILTPIYLLSMSRQMFYGYKLINVQNFSFFDSGPREFFLSISSLLPIIGMGIYPDFVLALASNKVESILSNYFYG
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: BKRB1_CHLAE
Sequence: MASWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICSFGLLGNLFVLLVFLLPRRRLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRGINGVIKANLFISIFLVVAISQDRYCLLVHPMASRRRQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILAFLLPLAAIVFFNYHILASLRGREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAIRGCFWEDFIDLGLQLANFLAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
What is the function of this protein?
This is a receptor for bradykinin.  Could be a factor in chronic pain and inflammation.
What are the official names of this protein?
B1 bradykinin receptor, B1R, BK-1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNZ_CLOK5
Sequence: MLDVCLLGCGGSMPIPDRNLTAMIVSYQGRKLLIDCGEGTQVSLKILGWKIRNIDVILFTHFHADHIAGLPGLLLTIANSGRLEPITIIGPYGLIKIVMGLKVIAPVLPYSIELVELHGKEKYFQKIGYFNINILSVDHGIPCFAYSIDVQRNRKFDREKALKNKVPLIFWSKLQKGEEIKQRDKLYTPDMVLGYGRRGLKISYCTDSRPSRELVEFVKKSDVFICEGMYGDDEKKHKAISYKHMIFSEAAVIAKEAEVEELWLTHFSPSLIEPQAYIENAKNIFKNTIIGQDRYVKSINFKE
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: KGX33_CENSC
Sequence: DRDSCVDKSRCAKYGYYGQCEVCCKKAGHRGGTCDFFKCKCKV
What is the function of this protein?
Blocks Kv11/ERG potassium channels.
What are the official names of this protein?
Potassium channel toxin gamma-KTx 3.3, CsErgTx2, CsErg2, ErgTx2, Ergtoxin-like protein.
What is the protein family that this protein belongs to?
Belongs to the ergtoxin family. Gamma-KTx 3 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NU4M_ATRNM
Sequence: PIAGSMVLAAILLKLGGYGIIRMMQILPTTKTDLFLPFIVLALWGAILANLTCLQQTDLKSLIAYSSISHMGLVVAAIIIQSPWGLSGAMALMIAHGFTSSALFCLANTTYERTHTRILILTRGFHNILPMATTWWLLANLMNIATPPTLNFTSELLIMSTLFNWCPTTIILLGLSMLITASYSLHMFLSSQMGPTPLNNQTEPTHSREHLLMTLHLAPLMMISMKPELII
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.