PharMolix/UniProtQA huggingface dataset:
Protein: PT1_STRCO
Sequence: METTLRGVGVSHGVAIGEVRHMGTAVLEPPAKQIPAEDAEREQGRARKAVEAVAADLMARGNLAGGEAQAVLEAQAMMAQDPELLADVERRITVGSTAERAVYDAFAAYRALLAGAGEYLAGRVADLDDVRNRIVARLLGVPMPGVPDSDEPYVLIARDLAPADTALLDPTLVLGFVTEEGGPTSHSAILARALGVPAVVALPGAGEIPEGTVVAVDGSTGEIFVNPAEEKKARLAAEAAERKAALAAATGPGATSDGHKVPLLANIGGPADVPAAVEAGAEGVGLFRTEFLFLDDSANAPSEEKQITAYRQVLEAFPEGRVVVRVLDAGADKPLDFLTPGDEPNPALGVRGLRTLLDHPDVLRTQLTALAKAAEGLPVYLEVMAPMVADRADAKAFADACREAGLRAKFGAMVEIPSAALRARSVLQEVEFLSLGTNDLAQYTFAADRQVGAVSRLQDPWQPALLDLVALSAEAAKAEGKSCGVCGEAAADPLLACVLTGLGVTSLSMGAASLPYVRATLAKFTLAQCERAAAAARAADSAEEARTAAQAVLSGE
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
What are the official names of this protein?
Phosphoenolpyruvate-protein phosphotransferase, Phosphotransferase system, enzyme I.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_LEPIC
Sequence: MENIIVTQVKSSIGVKKEHKLTLHALGLRRTGQQRKHKVSPQLQGMLNSVRHLIKVEKA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: Y786_MYCTU
Sequence: MQLTHFGHSCLLAEFGQTRLLFDPGTFSHGFEGITGLSAILITHQHPDHIDVTRLPTLLEDNPAAELYADPQTAAQLGEPWRAVHVGDELPLAELTVRAVGGCHAVIHPEIPVIENISYLVGDSKHRARLMHPGDALFVPGEQVDVLATPAAAPWMKISEAVDYLRAVAPARAVPIHQAIVAPDARGIYYGRLTEMTTTDFQVLPEESAVTF
What are the official names of this protein?
Protein Rv0786c.
Protein: INS_PIG
Sequence: MALWTRLLPLLALLALWAPAPAQAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREAENPQAGAVELGGGLGGLQALALEGPPQKRGIVEQCCTSICSLYQLENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RK22_IPOPU
Sequence: MYQVLKKKKPEVYALGQHISMSADKARRVIDQIRGRSYEETLMILELMPYRAGYPIFKLVYSAAANASYTMASNEANLVISKAEVNEGTTVKKFKPRARGRSYPIKRTTCHITIVLKDISLDDSESIELNLLKKPRWKKNSTAMAYYDLHNRGGLWDKK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MIAB_RHOPB
Sequence: MTQPRKLHIKSFGCQMNVYDAQRMVDALAPEGFVETANADEADLVILNTCHIREKASEKVYSELGRLRVAKDEAALQGRRMNIAVAGCVAQAEGAEIIRRQPAVDVVVGPQSYHHLPQLLAEAARGGRALETEFPVDDKFGFLPPPQPDAIRARGISAFVTVQEGCDKFCTFCVVPYTRGAEVSRPVDKIVEDVRRLADNGVREITLIGQNVNAYHGDGPDGRPWPLGALLHHLAKIPGIVRLRYSTSHPRDVDQSLIDAHRDLPALMPFVHLPVQSGSDAILAAMNRKHSADDYRRLVDRFRSANPAIAFSSDFIVGFPGETDEDFAATLALVTQIGYAGAYSFKYSPRPGTPAAELQETVSAAVMDERLVRLQELIDSQQAAFNAAVIGTTVEVLFERAARNPGQIVGRTAYLQPAHVMAAPDIIGQVLPVRIDSLERYSLIGELAAPQQHSGFATRSEDSPQSLPITTGA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCR_PANAY
Sequence: MSTEQFDPMTFALFLGALSLIPILMIVCTCFLKISMVLLITRNAIGVQQVPPNMALYGIALAATLFVMAPVFNQMQQQFSQAPADMSNMDNLKTSITNGVAPLQKFMTHNTDPDILIHLQENSVKMWPKPMSDDVSKDNLLLVIPAFVLSELQAGFKIGFLIYIPFIVIDLIVSNVLLTLGMQMVTPMTLSLPLKMLLLILINGWTRLLDGLFYSCL
What is the function of this protein?
Required for the secretion of harpin.
What are the official names of this protein?
Harpin secretion protein HrcR.
What is the protein family that this protein belongs to?
Belongs to the FliP/MopC/SpaP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VE4_HPV08
Sequence: MADHKAPPPPDHHQDKQTQTPPPRPPPPPLTPRPDSSGPLQNSHNKPKPKDEGTGDGRPAEQDRKKSRGDQGRDTAPGLAPGRSPGLGPLAPPPYPGPGPRRSPRQFGPGPDRDPEDGLQPPLGEGQVEGHPGDGDQPQGHPPPTPSNGHKGEEGDGEEEGAVGGDGNDHPPPPPPPPNVQEGSLLGCVGSLLLKWEDQFNLLVQNIQGDLEDYWTKLSTPQ
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: PSBK_STIHE
Sequence: MESILMIFAKLPEAYAPFDPIVDVLPVIPVLFLLLAFVWQAAVSFR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y1621_HAEIN
Sequence: MHLSEGVLHTPILLAGAVLAVAGIAVGLRRLESERLPLTALFAAAFFVAGTIHVPVGIGSVHLILNGMAGLFLGWAVFPAFLIALLLQVIFFSFGGFAVLGVNLCVMATPAVIAHYLFRSRLQPQMALKDRLLVGIGAGVIGVGGAGALASFVLMLDGGKSYLNLVWLLLVSHIPVFILDSIISVGVITLLGKMYPEVMNRTENFS
What is the function of this protein?
May be involved in metal transport.
What are the official names of this protein?
Putative metal transport protein HI_1621.
What is the protein family that this protein belongs to?
Belongs to the CbiM family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NDC80_YEAST
Sequence: MQSSTSTDQHVLHHMDPHRFTSQIPTATSSQLRRRNSTNQGLTDMINKSIARNTISGTGIPTGGINKNKRTRSTVAGGTNGTALALNDKSNSRNSVSRLSINQLGSLQQHLSNRDPRPLRDKNFQSAIQEEIYDYLKKNKFDIETNHPISIKFLKQPTQKGFIIIFKWLYLRLDPGYGFTKSIENEIYQILKNLRYPFLESINKSQISAVGGSNWHKFLGMLHWMVRTNIKLDMCLNKVDRSLINQNTQEITILSQPLKTLDEQDQRQERYELMVEKLLIDYFTESYKSFLKLEDNYEPSMQELKLGFEKFVHIINTDIANLQTQNDNLYEKYQEVMKISQKIKTTREKWKALKSDSNKYENYVNAMKQKSQEWPGKLEKMKSECELKEEEIKALQSNISELHKILRKKGISTEQFELQNQEREKLTRELDKINIQSDKLTSSIKSRKLEAEGIFKSLLDTLRQYDSSIQNLTRSRSQLGHNVNDSSLKINISENLLDRDFHEGISYEQLFPKGSGINESIKKSILKLNDEIQERIKTIEKDNITLEKDIKNLKHDINEKTQINEKLELELSEANSKFELSKQENERLLVAQRIEIEKMEKKINDSNLLMKTKISDAEELVTSTELKLEELKVDLNRKRYKLHQQVIHVIDITSKFKINIQSSLENSENELGNVIEELRNLEFETEHNVTN
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Kinetochore protein NDC80, 80 kDa spindle component protein, Nuclear division cycle protein 80, Two-hybrid interaction with DMC1 protein 3.
What is the protein family that this protein belongs to?
Belongs to the NDC80/HEC1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Protein: GLMU_ECOLU
Sequence: MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REX_CARHZ
Sequence: MKGFKIPEATISRLSVYSRYLENLYRKGITTVSSADIAQGVGVTSAQVRKDLAYFGEFGTRGVGYNVKELLDHTLKILGLNNTWNMVVVGAGNLGSALCAYRGFRERGFYIVGVFDNDLTKIGKKINEYEVLPIDKLEEVVRENNVEIGIIAVPAAYAQDVATRLVKAGVKGILNFAPTVLNVPDKVIVRSVDLTVNLEVLTFNIRRD
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y955_TREPA
Sequence: MTGVPTPILIIPIHEIKSFQNRLDIRDAARWIALATVLERAQFFLKNFTIFELFPGLPARHRRKHKLIFPLRSRAWLLWGSSRKVPLRFK
What are the official names of this protein?
Uncharacterized protein TP_0955.
Protein: GL89_ORYSJ
Sequence: MASPSFCLFAALLALVSWQAIASDPSPLQDFCVADKHSPVLVNGFACLDPKYVTADHFFKAAMLDTPRKTNKVGSNVTLINVMQIPGLNTLGISIARIDYAPLGQNPPHTHPRATEILTVLEGTLHVGFVTSNPNNTLFSKVLNKGDVFVFPVGLIHFQFNPNPHQPAVAIAALSSQNPGVITIANAVFGSKPPISDEVLAKAFQVGKGTIDWLQAQFWENNHY
What is the function of this protein?
Plays role in broad-spectrum disease resistance.  Probably has no oxalate oxidase activity even if the active site is conserved.
What are the official names of this protein?
Germin-like protein 8-9.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: CCF31_ORYSJ
Sequence: MEAAAAAAAEEEAGNPDGVEGAAVAAVAPEAAAEGPSEPNAGEASREPDAGQASREPGAAGPSREPDVAGPSREPDAAGPSREPGAAGGSREPGAAGGSRQPVPDAAQLAVVPYVEDIDRYLRSLEAEQTRRPMINYVQEIQGGIINMDVRGILVDWMADVAYVFNLQEETLHHAVSYVDRFLSKIAFPGDKLKLLGTTALFVASKYEEIHPPHVRNFSAVTVNTYTTQQVSKMELDILRFLNFDVGSPTVITFLRKFLTSCCGGNNSSNRKLELMCNYLAELSLLDDYYIRFLPSIVAAACLFVGKFTLNPNTRPWFGSVSTITPPENIKGGVEKYMVSRIYMCVFDLPMLFLMETWSSSGVSNHTKLQLKQNMMELPIENPTFISAS
What are the official names of this protein?
Putative cyclin-F3-1, CycF3;1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin F subfamily.
Protein: DUS29_TETNG
Sequence: MSSGVKSKSRNPYTAVRVDPDSDYVTPGTLDLEQLFWTGPEVQYTHVNLVWPGIYIGDEKTALELPGLRDLGITHVLNAAEGKWNNVLTGAGYYSDANICYYGVEADDKPTFNISQFFQPAAQFIHEALSQPHNNVLVHCVMGRSRSATLVLAYLMMRHSLSVVDAVEQVRQRRCILPNHGFLKQLRALDITLQEERLRQKREAPGQEKHT
What is the function of this protein?
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity).  Involved in the modulation of AMPK and MAPK1/2 signaling pathways (By similarity).
What are the official names of this protein?
Dual specificity phosphatase 29, Dual specificity phosphatase DUPD1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MDH_XANOP
Sequence: MKAPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLELSNEKAQAALKGVMMELEDCAFPLLAGMVGTDDAEVAFKDIDVALLVGARPRGPGMERKDLLLENAKIFTAQGAALNKVAKRDVKVLVVGNPANTNAYIAMKSAPDLNPNNFTAMLRLDHNRALSQLALKLGKPVGGIEKLVVWGNHSPTMYPDYRFATSDGASIGDAINDQEWNASTFIPTVGKRGAAIIEARGLSSAASAANAAIDHVRDWVLGSNGKWVTMGVPSDGSYGISEGVIFGFPVTTENGQYSLVKDLPIDDFSQKYIDKTLAELEEERSGVSHLLG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: TGS1_MOUSE
Sequence: MCCEKWNHVAEMLLFIEDREEEYKILCLCSRAFVEDRKLYNLGLKGYYVKSSGNNAGDQGTEEEEDGHSNGTAESHSPNESDLDSEAKLMRSMGLPIQFGRMSSHENFEMSMNARNKAKVKQKRRKHQKRYLDEMVRESWRNDYEEDDLVVSDDPSSVEHCENNRTCEIQSKAGSEVENLPVENTLAPKLEVPENWEKYWNEYGEGLLWQSWQEKYPDQTLSSEPWNLPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFTASQNCDKDVYTSHTEVDQNAESSLKADVMTFSSSPNIVEDEIPGSNDNDHNEIITAINNITVSAEKVEQSQLDSSQHCDEPLSEITGKECPASGGSDSCNGTPKENDISENRSSDQPAKELQESSGTNKGKHRPHHNGADGHESDDDPPEHKPSKVKRSHELDVDENPDSEVDDNGFLLGFKHGSGQKYGGIPNFSHRQVRYLEKNVKYKSKYLDLRKQMPVKSKHILFTEDSGKPFVVCKSKVRSKVEKFLKWVNERVDEETSQDSLSQNKMQDTCTSSDSEEQDMSLEKADNLMETRDPEPEKCQIISSATELEAEKSEVGSLVATVPENCSTEEIPNSPHAETEVEIKKKKKKNKNKKINDLPPEIASVPELAKYWAQRYRLFSRFDDGIKLDKEGWFSVTPEKIAEHIAGRVSQAFRCDVVVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGIADKIEFICGDFLLLAPCLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQKITNNIVYFLPRNADIDQVASLAGLGGQVEIEQNFLNNKLKTITAYFGDLIRRPALLKTSTSEAEV
What is the function of this protein?
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure.  The enzyme is specific for guanine, and N7 methylation must precede N2 methylation.  Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs).  Plays a role in transcriptional regulation (By similarity).
What are the official names of this protein?
Trimethylguanosine synthase, Nuclear receptor coactivator 6-interacting protein, PRIP-interacting protein with methyltransferase motif, PIMT, PIPMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Protein: TM182_CHICK
Sequence: MKLSVGIFFGGLFAALGVLLFLVAFGTDYWLLATEIGRCSKAPEDAGTEKATFHHEGFFWRCWFSGNVREHNTSMWKFWYTNQSPSKNCTHAYLSPFPHIRDEHNSTSYDSAVIYRGFWTVLMLLGVITIVMASFLIICAAPFASHILYKAGGGFYILAGVLFSLVVVMYVIWVQAMADLENYTNMKKMDCPDFAVYVRYGWSFMLAPIGVFFALLAGMLFLLVGRAIYLNSD
What is the function of this protein?
Negatively regulates myogenesis and skeletal muscle regeneration via its association with ITGB1 (PubMed:34427057).  Modulates ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting ITGB1-mediated intracellular signaling during myogenesis (PubMed:34427057).
What are the official names of this protein?
Transmembrane protein 182.
What is the protein family that this protein belongs to?
Belongs to the TMEM182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLNE_BIFLD
Sequence: MESSIFKPSSMDLIRAGLQDLDKARALFDQLKADDIPDERCAELLSALAHACDPDMALSNFVDIVNAMQSSQRDLEHVIPDNDALKRLVTVLGVSDAMGKFMRFKPQLVEAAAVDNCNSHLFNHAQRRARLLKAVGADPDEPAMPVASKDLAEAATALRSSYRNQLAAIIAQDAVADDPTSIQPTISRELSDLADAALEGALAIARHETEGSEHVRFTIIGMGKLGAQELNYVSDVDLIYVVEPADKDVDHQTLIRVGTKMGTMLQRVCQSAIMGVAEQPLWQIDGGLRPEGKDGALVRVLSSHKNYYEQWAENWEFQALLKARPVAGDPDLGQAYMDMTRPFVWSASKRKNFVYDCQKMRKRVEDLIPAPLKDREIKLGRGGLRDVEFTVQMLQLVHGRTDESLRTSNTLDSLQRLSEGGYVSRKQAVRMSQDYRFERVMEHRQQIWSLKRTHLFPDLGRASVGGLEKKRDIDVDELNQNQELRRLARAFGLHPEELVDKYDDTRREVRHLHLDIYYRPMLPVNAQMENDQIVLSVEAAQERFESIGFGDPDAAIRHVQALTAGVGRAAKINRIILPAVLQWLGEGQNPDMGLLNWRKLEENFGTESGYLGFLRDSTSAAQRLCHILSNSRFLGDALNKSVESISWLGDDDNLQARTREALDVQTGSALERFGSNINEFATSMRAMRRHEIERIGLSWMSGVISDSDSLKAMTDVYDAIIDASLTWAVRHQIAEFGVETAPAGITVIAMGRYGGREVNFSSDADAILIYRPADDADDGQANAFAKKVVEDLRNILQGPTTLEPKIELDLDLRPEGKNGPLVRSYASCEEYYESWASTWERQALLRARYAAGDAELARDFLINIADPLRYPTTELTEAELQNIRKLKARMEAERLPRGVRRERHLKLGKGGLSDVEWTVQLMQLQHAGDIKDLRVNGTLEALDVLEAKKLISAIDAIQLRKAWTLCTAARNGSYLWSGRANQADILPDDIYSLGGIAVYLGYGAHRGQHFENDLLAVMRKCRDVCQRLFYGKTEGEAAAATTATASAATQQPQTAPRPRMHVIAPRLERNRRRAQR
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: SNAPN_MOUSE
Sequence: MAAAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGVYPPGSPSK
What is the function of this protein?
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes.  In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.  The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension.  Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.  May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25.  Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis.  May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:16760431, PubMed:19546860, PubMed:21998198).  As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery.  Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
What are the official names of this protein?
SNARE-associated protein Snapin, Biogenesis of lysosome-related organelles complex 1 subunit 7, BLOC-1 subunit 7, Synaptosomal-associated protein 25-binding protein, SNAP-associated protein.
What is the protein family that this protein belongs to?
Belongs to the SNAPIN family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Golgi apparatus membrane. Lysosome membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells.
Protein: SYGA_RICRS
Sequence: MKKLSFQQIILTLQNYWQDYGCAILQPYDAYVGAGTFHPATVLRCLGTKPWSVAYVQPSRRPGDSRYGMHPNRMQHYYQFQVILKPSPDNIQELYLKSLECLGIDLKIHDIRFVEDDWESPTLGAAGLGWEVWCNGMEVSQFTYMQQIGGIECRPVAGEITYGLERLALYIQGVDEVRELDWNGQVGEKALKYGEVDFEAEWQFSKYNLELADSEMLLRHFKDSEDQCERLIKANLPMPAYDECLKASHAFNQLNALGVISVTERASYVLRVRHLARICCTKWLEMNK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14Z_STRA3
Sequence: MAKKSMIAKNKRPAKFSTQAYTRCEKCGRPHSVYRKFQLCRVCFRDLAYKGQVPGVTKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: HIS2_BACHK
Sequence: MRNAFTLLFETIEERKNNPLPESYTNYLFSKGEDKILKKIGEECSEVIIASKNNDNEELVKEMVDVLYHCFVLLAEKNIPLKDIMEEVTERNGKLSRVGDRREIDTL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_COLP3
Sequence: MAQLYFYYSSMNAGKSTHLLQSSYNYQERGLVTAIYTAKIDDRFAKGKVASRLGIDADAFLFDEKINLFKDVDQKHQAEKIDCVLIDEAQFLSTEQVKQLTDIVDLLHIPVLAYGIRTDFLGQTFSGSAALLAWADKLVELKTICHCGRKANFVIRQDANGKAVQNGEQVEVGGNERYEPLCRAHFKQLVWL
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_LACGA
Sequence: MAQQRRGGRRRKVDFIAANHIDYIDYKDVDLLKRFISERGKILPRRVTGTSAKNQRKLTVAIKRARVMGLLPFVAED
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RSSA_ASPFN
Sequence: MAPSQLPPIFNPTQQDIEQLLAAQCHLGSKNLQVHMEPYLWKTRPDGVNVINIGKTWEKILLAARIIAAVENPADICVISARPYGQRAVLKFAAHTGATAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDSQAIKEASYVNIPVLALCDTDSPTDFVDVAIPTNNKGRHSIGLVWWMLAREVLRLRGTLATRETEWDVVPDLYFYRDPEAEENKEIADESKVATAEEVGAGAIESGFAGENWDTQGAGAGVPGTAFAAASAAGPTSWEADGADWAASSAPAAAGESWAETQPAEGKW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.