PharMolix/UniProtQA huggingface dataset:
Protein: G6PI_FRATH
Sequence: MLFCDDSKKYLKEQNINLKNEFDKDDKRVEKFSLKHQNIYFDYSKNLINNYILKSLLESAEKSSLKDKIKQMFNGAKINSTEHRAVLHTALRDLSSTPLIVDGQDIRQEVTKEKQRVKELVEKVVSGRWRGFSGKKITDIVNIGIGGSDLGPKMVVRALQPYHCTDLKVHFVSNVDADSLLQALHVVDPETTLFIIASKSFSTEETLLNSISAREWLLDHYEDEKAVANHFVAISSKLDKVKEFGIDLEHCYKMWDWVGGRYSLWSSIGMSIAFAIGYDNFEKLLAGAYSVDKYFKETEFSKNIPVIMALLASYYSCTYNSQSQALLPYDERLCYFVDYLQQADMESNGKSVNIAGGTVNYQTGVVLWGGVGTNGQHAFHQLLHQGNIFIPVDFIAIATSHHNYDNHQQALLANCFAQSQALMFGQSYDMVYNELLKSGLNETQAKKLAAHKVIPGNRPSTTILLDELSPYSLGALIALYEHKIFVQGVLWDINSYDQWGVELGKKLGKNILKAMNDDSSDEYQNLDDSTRQLIAKVKNK
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_OENOE
Sequence: RIRYKGIVCDRCGVEVTSSKVRRERMGHIELAAPVTHIWYFKGIPSRMGLILDMSPRSLEEIIYFASYVVINPGNTPLEKKQLITEAEYRQYQDQYGTDTFDAKMGAEAIKELLAEVDLEKHAKELKNELKDATGQKRTRAVRRLDIVEAFIQSGNKPEWMVMDVVPVIPPDLRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPGIIVQNEKRMLQEAVDALIDNGRRGRPVSGPGNRPLKSLSHLLKGKQGRFRQNLLGKRVDYSGRSVIDVGPFLKMNQMGLPRQMAVELFKPFIYNRLIELGTENGGANNLRSARRLVERHEDVVQDVLEEVVKEHPVLLNRAPTLHRLGIQAFEPVLVSGKAMRLHPLVTTAYNADFDGDQMAIHVPLSDEAQAEARLLMLAASHILAPKDGKPIVAPSQDMTIGNYYLTTEEAGIKGEGMIFSSADEVKMALQNHEVELHTRIGIAASSFDKAKPFTDHQRARIMVTTVGKVIFNEILPDDFPYINEPKSENFNGIDGRFFLDPGTDIVGWFKNESLNGPFKSGFLSDIIAQIYARYQVTRTSVLLDDMKDLGYNISTRSGLTVRMSDVTELPEKGEVLKEAHEKVAKITKQFRRGLLTDDERYIQVTQTWSDAQDKIKSMLIASFDSKNPIFMMSDSGARGNISNSFQLAGMRGLMAAPNGKVIELPVTANFREGLCVLEMFISTHGARKGMTDTALKTANSGYLTRRLVDVAQEVIVREEDCGTDRGLDVSAIMDGNEVIEPLYDRILGRYAMKPVIDPKTGEVIAKKNQMIDEHVADQIIDAGIQTVTIRSIFTCRTEHGVCVKCYGRNMATGDIVEVGEAVGTVAAQSIGEPGTQLTMRTFHTGGVALSEDITQGLPRVQEIFEARNPKGRAEISEVTGKVTSIEENPADRTKTVTIEGETDTREYVLPISARLRVAEGDEIHRSEAINEGPLDPKELIKVSSTLKTENYMLAEVRKVYRMQGVGIA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: KLP2_SCHPO
Sequence: MEEEGHKSLTSHLPQSSSSLSQSREIAKEFTSNIPPPTIKTNSSSSNILKPRLSLQNEVNQLKPAKFPSKMLPPGSLASVKSSSLAKKARPFTASSNPRMPKSAHPISSRSVSASSHFGRPASAVSSSLNSSDDVRSMSDESMESYNDEKSVNASALRTTEDRLRSMEMAYAQLSAKVIPSPSKRPANYKFYEQRIAMLEESLEVERSRTSELQEQFSVALREKAEAEANKIVSQKGMESLEIMLNSMKSENHQRMAMLEENHARVMETAELQHQAELQDFASNIEQKANSLIMEYKNELQSAEEHFSHKIKELTSENELKISRLQEEKDSLLKKVQEGASLAMQRVQNKHDLEKKRLQSAIQPLQEENNSLKQQIEQLQRELASETVVKENLKSSLDQQSANVQKLESTNRALESTIKTLEEDVYTMKNKIIELEGILKSANVERDGLVEKLIAEETLRRKLHNTIQELKGNIRVFCRVRPPLGDGESAQIAFPDQNSEASTIEIVAQAPGSSLTGNGIKQYAFNFDRVFSPETTNEDVFNELSQLIQSAMDGYNVCIFAYGQTGSGKTHTMSSNTGMIPSSVRMIYNRSTSLKERGWEYRMEGQFLEIYNETIIDLLASGNEEEKGKKKLEIYHDTKAGRTTITNITSEPLDTPEQVTWLLDQASKNRSVAATNANEHSSRSHSVFMLHLNGSNSTTGETCRSTLNLIDLAGSERLSSSQSVGERLKETQAINKSLSCLGDVIHALGSGKEGTYIPYRNSKLTNLLQYSLGGNSKTLMFVNISPLKQHVPETLCSLRFATKVNNTQIGTARKVTK
What is the function of this protein?
Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle.  Required for the polarization of interphase microtubules where it orients the microtubule plus ends toward the cell ends and the minus ends toward the cell center.  Mediates minus end-directed sliding of cytoplasmic microtubules relative to each other, thereby promoting mitotic spindle disassembly.
What are the official names of this protein?
Kinesin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Note=During interphase. When in the nucleus, it associates with chromatin.
Protein: AAEB_ECOLC
Sequence: MGIFSIANQHIRFAVKLATAIVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGFLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRIENSYAWGLAGYTALIIVITIQPEPLLTPQFAVERCSEIVIGIVCAIMADLLFSPRSIKQEVDRELESLLVAQYQLMQLCIKHGDGEVVDKAWGDLVRRTTALQGMRSNLNMESSRWARANRRLKAINTLSLTLITQSCETYLIQNTRPELITDTFREFFDTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWVAAATRYQLLKRGVISNTKINATEEEILQGEPEVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCISLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAVSAMTTNVARRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSAFHRQMRRTADHVISARSDDKRRRYFGQLLEELEIYQEKLRIWQAPPQVTEPVHRLAGMLHKYQHALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y8656_DICDI
Sequence: MDIECDIRKINKLNYNNENEIYKLKKLNHPSIIKHYDIDEKKSEKNVIIYQESINGGISIDKFDNNNFFSQEVIREICEQILLALRFMDNHQIVHRDLNCSNVIIFPETLTIKIIDFGVTKTNFLNQDYQSPEVLKSNNFTHKSDIWSFGFILLKMIDKSLNNIPDDLPTEQFDFLHSCLATNLSDRLDAQTLLHHPFIINKPILRFSKSMKLISSPKKQFELVNKTEHEIILLTNGTSETFYLNKNESCKIKISTIDLYIGVRFDDGAILSSPRPTKLIEQEGTDINSFIIDQSCLMAHNITFPNISFFESISEII
What are the official names of this protein?
Probable inactive serine/threonine-protein kinase DDB_G0268656.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: CLD17_MOUSE
Sequence: MAFYPLQIAGLVLGFFGLVGTIGTTLLPQWRVSAFIGSNIIIFERIWEGLWMNCIQQAMVTLQCKFYNSILALPPVLEAARALMCVAVALALVALIIGICGMKQLQCTGSSERVKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYDPTVHAGQKRELGGALFLGWATAAVLFIGGGLLCGYCCCNRKERWHRYPVPAYRVPQKDNQRNVTVPRKSSTSYV
What is the function of this protein?
Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter.  In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions.  Does not affect water permeability.
What are the official names of this protein?
Claudin-17.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: RL21_AFIC5
Sequence: MFAVIKTGGRQFRVVPNDVLEIGKITGDVGTIVQLGEVMAVGGDTPVLGFPFIEGASVAAEILDHKRGPKVIAFKKRRRKNSKRKRGYRDEITVIRVTEILTDDKAPTIGPRAKKEKKVEAAPADGEAPAKKAPAKKAAAKKAAPKAAAKKAPAKKAAPKAKSE
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: VRAX_STAAN
Sequence: MIIYRQYHHEGAPVYEIITKTFQHVSIKCDDSFSDTEIFKLLSLLQDDIDHMKVS
What are the official names of this protein?
Protein VraX.
Protein: VPB13_ARCFU
Sequence: MPKIIEAIYENGVFKPLQKVDLKEGERVRVVVSEVVAKTRGLLKGCEMEEIIEEIESEGFL
What is the function of this protein?
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.  Its cognate toxin is VapC13 (Potential).
What are the official names of this protein?
Putative antitoxin VapB13.
What is the protein family that this protein belongs to?
Belongs to the UPF0165 family.
Protein: RL30A_SCHPO
Sequence: MASVVTKKSKKSGDTINAKLALTMKSGKYVLGYKSTLKTLRSGKAKLILIAGNCPPLRKSELEYYAMLSKANVHHYAGTNIDLGTACGKLFRVGVLAITDAGDSDILDA
What are the official names of this protein?
60S ribosomal protein L30-1, L32.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
Protein: DXR_TOLAT
Sequence: MQYLTILGSTGSIGRSTLDIVRRHPDRFAVTALTANQGVAQMMSDCLEFHPSYAVMADEASAIALKEALAGHKLKTEVLTGTDALCQVAAHSSVDIVMAAIVGAAGLLPAMAAIKKGKTVLLANKEALVMSGRLFMDAAHHYSARILPVDSEHNAIFQCLPAEAQSALGNCDLSAAGVDKILLTGSGGPFRYTSLSQLSSVTPEQAVAHPNWSMGRKISVDSATMMNKGLEFIEAKWLFNATEEQIQVIIHPQSVIHSMVQYRDGSVLAQMGQPDMRTPIAHALGFPERVASGVSPLDFSRVGELSFLPVDFERYPCLKLAIEACWAGQGATTALNAANEIAVDAFLSGKIGFTQIHTVVLDVLSELKQANINDLESILAIDAEARLMAHQKITRLAV
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: FZD3_CHICK
Sequence: YPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILR
What is the function of this protein?
Receptor for Wnt proteins.  Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts.  Involved in the migration of cranial neural crest cells.  May also be implicated in the transmission of sensory information from the trunk and limbs to the brain.  Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway.  Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP).  Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).
What are the official names of this protein?
Frizzled-3, Fz-3, cFz-3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell surface. Apical cell membrane; Multi-pass membrane protein.
Protein: CCNE2_HUMAN
Sequence: MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTHTNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH
What is the function of this protein?
Essential for the control of the cell cycle at the late G1 and early S phase.
What are the official names of this protein?
G1/S-specific cyclin-E2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin E subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YGL8_YEAST
Sequence: MPPEPVWHISAVTEKFPTHGAILYISLTFSFYKKMLRVLWHILLVYGKHAGKRKYRKVMTETNDSLYMKRNNCSGEYATLALSTRSCSFNMQQNDWVTMEGLFPFVMVLCHLETKPMKIGIQLILQVPFMGLGIHKENKEFYLIL
What are the official names of this protein?
Uncharacterized protein YGL118C.
Protein: PHOSP_ABLVH
Sequence: MSKIFVNPSAIRAGMADLEMAEETVDLINRNIEDNQAHLQGEPIEVDSLPEDIKKLDISEGRSKSLVDNPQDVECRMSEDFQMDEVEDPNIQFQSYLDNIGIQIVRKMRTGERFFKIWSQTVEEIISYVGVNFPSQSGKTTENKSTQTTPKKVKTEPSSTPAKRSDQLSKTEMAAKTASGPPALEWSTTNDEDDVSVEAEIAHQIAESFSKKYKFPSRSSGIFLYNFEQLKMNLDDIVKEAKSVPGVTSLARDGLRLPLRCILGWVGSSHSKKFQLLVGSEKLNKIMQDDLNRYMSC
What is the function of this protein?
Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication.  Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA.  Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity).
What are the official names of this protein?
Phosphoprotein, Protein P, Protein M1.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus protein P family.
What are the subcellular locations of this protein?
[Phosphoprotein]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P2]: Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P5]: Host nucleus.
Protein: SYK_LEPBJ
Sequence: MLDSNELIQQRIQKIEDLKNQGINPYPVRFFPDSKSKDIVEKFEKDPTGPETKFKLGGRLHSKRVMGKASFAHLKDSTGIIQLYATRDDLGEISYSIFKSLDLGDIIGLEGYLFKTQKGEVTLHVTSVELLAKCIRPLPVVKEKDGVIYDAFADVEQRYRMRYVDLVVNDHVRDTFITRSRIVSEIRNFLTNEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLIVGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYIAFADMNTMLDLTERLITHLAQKIHGALKIQYGKDLIDLSPPWRKITYTDIIKEYSGIDFSLITSLEEAKKKASELNVDVSKCNTIWKVADEVFSEKAEPNLIQPVFIIDYPKELSPLAKSNPDKPGYVERFEPYVAGREIGNAFTELNDPFDQKERFEDQVQQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTDSHSIRDTILFPLMRPE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP11_SCHPO
Sequence: MSNPDVDLDSIIDRLLEVRGSRPGRQVQLSEDEIRFLCNKAREIFISQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLEVICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMDQIQRIMRPTDVPDTGLLCDLLWSDPDKDLTGWGDNDRGVSFTFGPDVVSRFLHKHDMDLVCRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAEKKQRYGYQGSSQNWHMTPPRKNKTGNSK
What is the function of this protein?
Essential role in cell cycle control.  PP1 is perhaps required for exit from mitosis.
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-1.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRMD_BARQU
Sequence: MKFQARVLTLYPEMFPGFLGYSLAGQALERGIWSLETVQIRDFALDKHHSVDDTPAGGGAGMVMRADVLAAALDSCPHDSTRLLMSPRGRPFNQAYARFLACESGVTLVCGRFEGVDERIIEARKLEEVSIGDYILSGGETAALVLLDAIVRLLPGVMGNEASGKCESFENGLLEHPQYTRPSIFEGRCIPPVLTSGHHKAIADWRQQQAELLTRQRRPELYALYDKNRQKT
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_BACVZ
Sequence: MEPLKTHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFFDWRYLENGEPDPEFELNRKVYEGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPSFADIFHQNCFKNGMLPIRMPYDQWKKLAGQYENQSLNMTVDLENQLIHDSEGKEISFEVDPHWKEMLINGYDEISLTLLLEDDIQQFESKRSSWLQA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: VIRB6_RHIRD
Sequence: MNFTIPAPFTAIHTIFDVAFTTGLDSMLETIQEAVSAPLIACVTLWIIVQGILVIRGEVDTRSGITRVITVTIVVALIVGQANYQDYVVSIFEKTVPIFVQQFSVTGLPLQTVPAQLDTIFAVTQAVFQKIASEIGPMNDQDILAFQGAQWVLYGTLWSAFGVYDAVGILTKVLLAIGPLILVGYIFDRTRDIAAKWIGQLITIGLLLLLLNLVATIVILTEATALTLMLGVITFAGTTAAKIIGLYELDMFFLTGDALIVALPAIAGNIGGSYWSGATQSASSLYRRFAQVERG
What are the official names of this protein?
Protein VirB6.
What is the protein family that this protein belongs to?
Belongs to the TrbL/VirB6 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL27_RUEST
Sequence: MAHKKAGGSSRNGRDSAGRRLGVKLYGGQSAIAGNIIVRQRGTKFWPGEGVGIGKDHTIFATANGNVTFHKGLKGRTFISVLPAAEAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: MTM1_YEAST
Sequence: MSDRNTSNSLTLKERMLSAGAGSVLTSLILTPMDVVRIRLQQQQMIPDCSCDGAAEVPNAVSSGSKMKTFTNVGGQNLNNAKIFWESACFQELHCKNSSLKFNGTLEAFTKIASVEGITSLWRGISLTLLMAIPANMVYFSGYEYIRDVSPIASTYPTLNPLFCGAIARVFAATSIAPLELVKTKLQSIPRSSKSTKTWMMVKDLLNETRQEMKMVGPSRALFKGLEITLWRDVPFSAIYWSSYELCKERLWLDSTRFASKDANWVHFINSFASGCISGMIAAICTHPFDVGKTRWQISMMNNSDPKGGNRSRNMFKFLETIWRTEGLAALYTGLAARVIKIRPSCAIMISSYEISKKVFGNKLHQ
What is the function of this protein?
Involved in the mitochondrial activation of SOD2 by specifically facilitating insertion of the essential manganese cofactor.  Has the ability to activate iron regulon in an iron-dependent manner.  Responds to calorie restriction (CR) strength.
What are the official names of this protein?
Mitochondrial carrier protein MTM1, Manganese trafficking factor for mitochondrial SOD2.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TIG_ACTSZ
Sequence: MSTIETTQGLERRVSITIPADEVETAVREQLKGFAKNARVDGFRKGKVPHHIIAQRFGSSARSEALNDLLPRHFFDLAFKEKLNLAGRPTFAVENAESGKDVVFTATFEVYPEVELKGLENIKVEKPVVEITEADVDNMIEVLRKQQATWAESQAAANAEDRVTIDFSGTIDGEEFEGGKASDFVLFMGQGRMIPGFEEGVIGHKAGEQFDIDVTFPADYHAENLKGKAAKFAITLKKVEVMVLPELTEEFVAKFGPNTKTVADLRNEIQKNMRRELKNALTSRVKQQVIDGLLAENAIDVPFAAVDQEIEVLRGQAAQRFGGNTQQAAQLPRELFEEQAKRRVQVGLLFGEIISSNELKADEERVKAMIEDIASAYEQPAEVIEYYNKNNELMNNLRNVVLEEQAVDAVLAKAQVTEKTASFDEIMNPQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: KDSB_RICPU
Sequence: MRHQDVAIIIPSRLSSTRLKQKPLQLIGSITLIERVFKQVNQAGLEHTYVATDSEEIASVITKVGGKVIFTDSAIPTGTNRTYEAFKLIPNNQNINYIVNVQGDMPFIEPSSILKIIEYLKNSKYDIVTPIVKVDRESVKASSNVTVAVDSAGTALYFSRSLIPNGAEEFLYHVGMYGFRKNALEKFVSLKPTFLEKTERLEQLRVLENGMTIGTCLVENVPISVDTEEDLKKAVKFYENISKLGL
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMG_NEIM0
Sequence: MTEVIAYLIEHFQDFDTCPPPEDLGMLLEEAGFDTMEIGNTLMMMEVLLNSSEFSAEPADSGALRVYSKEETDNLPQEVMGLMQYLIEEKAVSCEQREIIIHALMHIPGDEITVDTAKVLTLLLLWANKSELPVLVGDELMSALLLDNKPTMN
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: TPIS_XENTR
Sequence: MSSRKFFVGGNWKMNGDKKSLTELINTLNSGKISADTEVVCGAPTIYLDFARQKLDAKFAVSAQNCYKVAKGAFTGEISPAMIKDCGATWVILGHSERRHVFGESDELIGQKVAHALSENVGVIGCIGEKLDQREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPEQAQEVHKKLREWLKTNVSEDVAKSVRIIYGGSVTGGTCKELGAQPDIDGFLVGGASLKPEFIDIINAKQ
What is the function of this protein?
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
What are the official names of this protein?
Triosephosphate isomerase, TIM, Methylglyoxal synthase, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_HAEIE
Sequence: MKNIQKILPLYFVAGTQDCRHLGENLSENLLFVLKQALEGGITCFQFRDKGKFSLEHTPSAQKALAMSCRDLCREYGVPFIVDDNVDLALEIEADGIHVGQSDMPVQEIRAKTDKPLIIGWSVNRLDEAKIGENLAEIDYFGIGPIFPTQSKENPKPTLGMAFIQTLRNVGITKPLVAIGGVKLAHVKTLREFGADGVAVITAITHADNVQAATKALREASDEYAK
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RL11_PSEPG
Sequence: MAKKIQAYIKLQVKAGQANPSPPVGPALGQHGVNIMEFCKAFNARTQGQEAGLPTPVIITVYSDRSFTFETKSTPASVLLKKAAGLTSGSARPNTVKVGTVTRAQLEDIAKAKQADLTAADLDAAVRTIAGSARSMGLNVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: 096R_FRG3G
Sequence: MWSQFIAILSQSMPIGVCRKYPVCQTHLKKLKVADLSQESKDSEMAAMTEYISSNRPWGQGSYPSNGYVSPVSGCTLHFGNVSTLHPDSAALDGRLREMAEVLGVQDYASAPVRVSSTGYIDKVKAMVYEIDGVESMSMADLMGCTQLHQLAGKVASDIQSGAINHREFAGEILSNMVGPLRELLPKEDCDSIVSILEKVRDGEAVSADEVFPIITKFQEAGF
What are the official names of this protein?
Uncharacterized protein 096R.
Protein: IRC22_YEAS2
Sequence: MRFSMLIGFNLLTALSSFCAAISANNSDNVEHEQEVAEAVAPPSINIEVKYDVVGKESENHDSFLEFYAEDTATLAYNVTNWEDTNITIFGVNGTIVTYPHGYPVADITGASIGPYEMEVNGTSKFGQDVTLNLPEGQYFLIPFLLASRFDEIVRIAAPPTLFEIVSPPISFFNPQFLSVQVIFLAIIGGVSYYYMKSKTNQRPSKKSATVKKVDESWLPETYKK
What is the function of this protein?
Is probably involved in a pathway contributing to genomic integrity.
What are the official names of this protein?
Increased recombination centers protein 22.
What is the protein family that this protein belongs to?
Belongs to the IRC22 family.
Protein: RL13_NANEQ
Sequence: MEFLGELIYDAEGLVLGRLASIVARNLKRGYRVKIVNAEKAIITGDPNMVKKEWLQKVKRGDYYKGPFYPKRPDNILKRVIRGMLPRKTARGRELLKNVKVYIGVPEELKDKPKLGLNLENAKGYPEALIKEVLKAKPKFERGNIKYIELGELSKYLGAKFT
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.