PharMolix/UniProtQA huggingface dataset:
Protein: RK21_STAPU
Sequence: MNTYAIIEAGGEQLQVQPGRFYDIRLNVPVTEFWENRKIVFSRVLMIRSESNTFLGKPWLEHATVNGRIFHPRRGNKLIIYKMRPKKHTSKKNGHRQTFMRLIIDSIFFNNQNL
What is the function of this protein?
This protein binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L21, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GPSB_LISW6
Sequence: MTSEQFEYHLTGKEILEKEFKTGLRGYNPEDVDEFLDMVIKDYSTFTQEIEALQAENIRLVQELDNAPVRTAPQPAPTFQAAAQPAGTTNFDILKRLSNLEKHVFGNKLDDND
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: UVRB_RICTY
Sequence: MNNFSIISAYKPAGGQPKAIDEIIAGLNSKKRSQMLLGITGSGKTFTMANIIERTNRPTLIMAHNKTLAAQIYLEMKSIFPKNAVEYFVSYYDYYQPEAYIVRTDTFIEKDSSINEQIDLMRHSATRSLLERRDVIVIASVSCIYGLGAPDLYYQMTVHLELGQSYPRDKLLNDLINLQYKRNDIGFERGCFRVKGDHIDIFPSHYSDKAWRLSFFGNELEYIHEFDPLTGEKLTQLDKAMVFGNSHFVMPQKTINNAISSIEVELQKHLDVLKSQDKLIEAKRLNQRTQYDLEMLTETGSCKGIENYSRFFTGRNAGEPPPTLFEYLPKDALLFLDESHVSIPQIRAMYNSDRARKEVLVEHGFRLPSALDNRPLKFEEWEKFRPQTVFVSATPGPFELEETGGTVVELIIRPTGLLDPECIIKPATNQVEDLISEIQTTITKGLRILVTTLTKKMAEDLTSYLQDLQYKTYYLHSNIHTLERIEILRDLRQGNIDILVGINLLREGIDIPECGLVAILDADKEGFLRSEVSLIQTIGRAARNSRGKVILYADKMTKSIDKAVSETLRRRQIQQEYNKKYGIIPKTINSAIHTLESLEEIHDNKLDKKQTNTLLNNPAKLKSYMDKLKKEMFKAASNLEFEQAAKLRNQLKTLEKAVLELS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_SHEB2
Sequence: MSNVFTHINADGNAHMVDVTEKAITEREARAEAFIEMASTTLEMIMSGSHHKGDVFATARIAGIQAAKKTSDLIPLCHPLMLTKVEVDLEAQPEHNRVRITSLCKLSGKTGVEMEALTAASVAALTIYDMCKAVQKDMVISQVRLLEKRGGKSGHFKV
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: BACE2_RAT
Sequence: MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGLALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
What is the function of this protein?
Responsible for the proteolytic processing of the amyloid precursor protein (APP).  Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.  It has also been shown that it can cleave APP between residues 671 and 672.  Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis.  Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus.  This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets.  Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
What are the official names of this protein?
Beta-secretase 2, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome.
Protein: DNAK_BACAH
Sequence: MSKIIGIDLGTTNSCVAVMEGGEPKVIPNPEGNRTTPSVVAFKNEERQVGEVAKRQAITNPNTIMSVKRHMGTDYKVEVEGKDYTPQEISAIILQNLKASAEAYLGETVTKAVITVPAYFNDAERQATKDAGRIAGLEVERIINEPTAAALAYGLEKQDEEQKILVYDLGGGTFDVSILELADGTFEVISTAGDNRLGGDDFDQVIIDHLVAEFKKENNIDLSQDKMALQRLKDAAEKAKKDLSGVTQTQISLPFISAGAAGPLHLELTLTRAKFEELSAGLVERTLEPTRRALKDAGFAPSELDKVILVGGSTRIPAVQEAIKRETGKEPYKGVNPDEVVALGAAVQGGVLTGDVEGVLLLDVTPLSLGIETMGGVFTKLIERNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMSADNKTLGRFQLTDLPPAPRGIPQIEVTFDIDANGIVNVRAKDLGTSKEQAITIQSSSGLSDEEVERMVQEAEANADADQKRKEEVELRNEADQLVFQTDKVVKDLEGKVDAAEVAKATEAKEALQAAIEKNELEEIRAKKDALQEIVQQLTVKLYEQAQAAAGQAEGAEGAQDAGAKKDNVVDAEFEEVKEDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: HEM1_VIBVU
Sequence: MSLLAIGINHHTASVDLREKVAFGPDKLANALQQLSQHEAVNGSVILSTCNRTEVYCDVKSGARSKVIDWLSQFHQIGLEELKPSLYVYEEQAAIRHLMRVSCGLDSLVLGEPQILGQVKQAYSDSREQQAVDASLEKLFQKTFSVAKRVRTETDIGGNAVSVAYAACTLAKHIFESLEKSTVLLVGAGETIELVAKHLHANGCSKMIVANRTRERALTLAEQFDAQVISLQEIPNHLAKADIVISSTASPLPIIGKGMVETALKQRRHQPMLLVDIAVPRDVEAQVGDLNDAYLYTVDDLQSIIDSNIEQRKVEAIQAEAIVAEESAAFMSWLRSLQAVDSIREYRQSANEIREDLLSKALLSLESGSDPEKVLRELSNRLTNKLIHAPTRALQLAAEQGEPAKLTVIRQSLGLDELK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: ARP4_ARATH
Sequence: MYGGDEVSAIVVDLGSHTCKAGYAGEDAPKAVFPSVIGAVDGVEAMDVDVDSTKTNSNSEDSKTESEKEKSKRKLYVGSQAMSYRRDHMEVLSPIKDGIVSDWDLVDNIWEHAFKSCLMIDPTEHPMLLAEPPLNTQQQREKAAELMFEKYKVPALFMAKNPVLTSFATGRATSLVVDCGGGSTTISPVHDGYVLQKAVVSSPLGGEFLTDCLLKSLESKGIKIRPRYSFKRKEVRAGEFQVEDVDIPDTTESYKLFCQRMIVGDIKDSICRVPDTPYDDKSYSNIPTTSYELPDGQTLEIGADRFKVPDVMFNPSIVQTIPGMEKYAEMIPSVRGLPHMVMESINKCDVDIRRELYSSILLAGGTSSMQQLKERLEKDLIEESPHSARVKVLASGNTTERRFSVWIGGSILASLGSFQQMWFSKSEYEEHGASYIQRKCP
What is the function of this protein?
Involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure.
What are the official names of this protein?
Actin-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP4 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized in the nucleus during the interphase, but is released into the cytoplasm during the mitotic phase (PubMed:12609034).
Protein: MINC_ALIFM
Sequence: MTKTADLKGSNFTLSVLHLPNDDVALALNMLEQKVAQAPSFFASAPVVVNIENVSNEINFVELKSGVERTGMIPVGITGCKDKEKQAQATAAGFAIMTSFTPQQVTQKANMQPTKVIKTPIRSGQQIYAKDADLVILNHVSPGAEVIADGSIHIHGTLRGRAIAGASGQAEAKVFCKNLQAELISIAGNYWLSDQIDKEYWHQNVMITMVEDRIQIDTLTL
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: TXND8_RAT
Sequence: MVQKIKSMREFKELLGAAGNRLVVVEFSAQWCGPCKMIAPAFQAMSLQYRNVMFAQVDVDSSQELTEHCSIQVVPTFQMFKHSRKVTPFSRLKRILCCFRSGPGSKKIFEFQGADIEKLEEKIQELM
What is the function of this protein?
May be required for post-translational modifications of proteins required for acrosomal biogenesis.  May act by reducing disulfide bonds within the sperm (By similarity).
What are the official names of this protein?
Thioredoxin domain-containing protein 8, Spermatid-specific thioredoxin-3, Sptrx-3.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus.
Protein: PRMA_PSEP1
Sequence: MPWLQVRLAISPEQAETYEDALLEVGAVSVTFMDAEDQPIFEPDLNTTPLWSHTHLLALFEADADPEQVFAHLRLLTGAELPEHQAEVIEDQDWERSWMDNFQPMRFGRRLWIVPSWHDAPEKDAVNLLLDPGLAFGTGTHPTTALCLEWLDGQQLEGTQVLDFGCGSGILAIAALLLGAREAVGTDIDVQAIEASRDNAQRNGIADEKLALYLPEHMPAMQADVLVANILAGPLVSLAPQLSGLVRPGGLLALSGILAEQGEDVAAAYAADFELDPIVVRDGWVRISGRRR
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_CELJU
Sequence: MNTSVDKILSQTAEVDQASVQPFTGSQKIYVQGSRNDIRVPMREISLDDTPTDFGGEKNPPVRVYDTSGPYTDPEVAIDLRAGLPDIRSAWIEERGDTEILSDSQSIFTRERLDDPKLAHLRFNLTRKARRAKPGMNVSQMHYAKKGIITPEMEYIAIRENMALAQVRELGVLNQQHPGMSFGANIPGEITPEFVRSEVARGRAIIPANINHVELEPMIIGRNFLVKINGNIGNSALGSSIEEEVEKLTWGARWGADTVMDLSTGKNIHETREWIIRNSHVPIGTVPIYQALEKVNGIAENLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRVTGIVSRGGSIMAKWCLAHHRENFLYTHFEEICEIMKAYDVSFSLGDGLRPGSIADANDAAQFGELETLGELTEIAWKHDVQTMIEGPGHVPMHMIKENMDKQLEVCKEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWYGCAMLCYVTPKEHLGLPNKKDVKEGIITYKIAAHAADLAKGHPGAQLRDNALSKARFEFRWEDQFNLGLDPDTARAYHDETLPKESAKVAHFCSMCGPKFCSMKITQEVRDYAAQQGVNVEGISEDQLVKMIDVEAEMQEKAREFIEQGAELYHKV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: MUL1A_DANRE
Sequence: MEDFPVLEMVCLGSSVALSGLFYYIYRKKRKTVDKLKEAPVMALDAKLIDLLNATPGKCLQYVVVEGTVQPVGEPLRSQFQESSVGVIQKLVLREHKLVWNSLGRIWTDSERVLLQRVNAVPFNLLGLNKSFVRVLCPLEATGPKMEIVHEKFHQATYGFTDLIGQYLSGEKPKGQLETEEMLKVGASLTVVGELILDTDRLLKIRPPTDGSEYFLSSADFETLLMEQEGQAEVWRVFACICALAGVAVLIWTGRRYYRQLKLRWEQENLRREFEGMGTGEREEDNGVENACVICLSNPRGCVLLDCGHVCCCFRCYQALPQPFCPICRQHIKRVVPLYQA
What is the function of this protein?
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology.  Promotes mitochondrial fragmentation and influences mitochondrial localization.  Inhibits cell growth.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
What are the official names of this protein?
Mitochondrial ubiquitin ligase activator of nfkb 1-A, E3 ubiquitin-protein ligase mul1-A, RING-type E3 ubiquitin transferase nfkb 1-A.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: RL15_HAHCH
Sequence: MKMNTLKPAEGSKQSPKRLGRGIGSGLGKTGGRGHKGQTSRSGGTIRPGFEGGQQPLQRRLPKFGFTSRVGRFSEEVRLSEIDSLGTDIIDLAALKAANIVDQQAKQVKVILSGEITRAVTVKGLKVTKGAQEAIQAAGGKVEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: AKH1_SCHGR
Sequence: MVQRCLVVALLVVVVAAALCSAQLNFTPNWGTGKRDAADFGDPYSFLYRLIQAEARKMSGCSN
What is the function of this protein?
This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
What are the official names of this protein?
Adipokinetic prohormone type 1.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: MIAA_CAUVC
Sequence: MESSDIASRIWLIAGPTASGKSAYALDLAERIDGEIVNADSMQIYAGLRVLTAGPSQEETARAPHHLFQIVDPALGWSVGRWLEAATQALAEIQARGKPAIVVGGTGLYFRALTHGLADVPPVPETQREISSLLYAARGETEFREILKPLDPEAEARIESGDRQRLVRAHAVAITTGKSLTAWQTDTKPALAPGSWKGLVLDPPRAELYARCDARLAVMVEQGALDEVRALETRGLDPALPALKAVGYREFAAHLRGETSLDQALDAARQETRRYAKRQLTWFRNQTPDWERIVP
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: Y907_METJA
Sequence: MVDGMKHLILKVTNRCNLNCIYCYANNKNNKDMDFKTAKNAIDYLLNLDNQIKIQFTGGEPLLNFNLIEKIVDYCNDNYSNCNIQYAIQTNATLINEKIAEKIKELDIKVGISIDGLEINDILRPYKNGKPSTLDTLKGMYILKSYNIPFGITTVVTNKNLPYLEEFVKYLIAFGVKSISFDLLKPKKKEHLTLMPNIEEFNKLLNKLGRYPIYIKNLQKRPKDKYCYLNSGDLLFVNEFGDIYLCPTLEGLSCLGNINDKNKIKLPKVKSKGCYAREFLIKTFKK
What are the official names of this protein?
Uncharacterized protein MJ0907.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
Protein: LEUC_BACHK
Sequence: MGKRLLDKLWERHVVTTNENGLDLLYIDLHLVHEVTSPQAFEGLRLTNRKVRRPDLTFATMDHNIPTKDVWNITDRIAKQQLDTLRANCKQFQVPLADIGDEEQGIVHVIGPELGLTQPGKTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLWQRKPKAMGIELKGKLQKGVYAKDIILHLLSKYGVAVGTGYVMEFYGETIGAMEMEERMTLCNMAIEGGAKAGIIAPDEKTFVYVKGRKYAPRDYETFEKKWFELYTDADAIYDLHISIDVTDLAPYVTWGTNPSMGVRIDEKLPEKHDVNDERAFSYMGLIPGQSTYDIPVQHVFIGSCTNSRLSDLEIAASVVKGRKVKEGVRALVVPGSKRVRDAAIQKGLHHIFEEAGFEWREPGCSMCLGMNPDQVPEGEHCASTSNRNFEGRQGKGARTHLVSPAMAAAAALYGHFVDTRKESYDGAISYS
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: TPS28_ARATH
Sequence: MEAIRVFGPKLGSRLSIRSHTTAFPACKLSRFPLTSFPGKHAHLVLLKATTIPLASGDKENNRKFEKLGPSEWGNQFLFAHVDLSEMDALEREIEALKPKVRDMFMSFKGMKSNKKNLFLIYLLVSLGLAHHFEDEIEESVKGCSQEMVEMMDGENDLYTVSIIFWVFRTYGHNISSDIFNRFKGHNGKFKECLATDAKGILSLYEAAHMGTTTDYILDEALSFTLSYLESLAANGTCKPNLVRRIRNALGLLQNKNVEILVAKEYIRFYEQEEDCDKTILEFSMLNLKFLQLHYLQELKLLTKWYKEQDFESKLPPYYRDRIVELHLATLAYINPKYSRVRIILTMIYTIQIILDDTCDRYASLREVESLAATIERWDHNDHAMEGLPDYLKSVAKFIFHTFQEFEREVSSESGGSYSLKATIEDCKRMMRSNLQLAKWAVTGHLPSFDEYLDVAGVEIAVYFTVAGILLGMENINKKEAYEWLIFRDKLVRAMSTKARLVNDLFGYKDDMRRGYVTNSINCYKKQYGVTEEEAFRKLHQMVADGDKMMNEEFLKPINVPHQVLKAVLDTLRAINICYDNEDGFTRLNGNLKNYITSMYVDL
What are the official names of this protein?
Terpenoid synthase 28, AtTPS28.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYK2_MOUSE
Sequence: MVGTMPLCGRRAILEDSKADGTEAQPLVPTGCLMVLLHWPGPEGGEPWVTFSQTSLTAEEVCIHIAHKVGITPPCLNLFALYNAQAKVWLPPNHILDTSQDMNLYFRMRFYFRNWHGMNPQEPAVYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGKHEFMNDVVSLRDLSSEEEIHHFKNESLGMAFLHLCHLALSRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRFLRAFRPGHLSQQVVMVKYLATLERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAGDPGPELPSGPPTHEVLVTGTGGIQWHPLQTQESERGNSRGNPHGSRSGKKPKAPKAGEHLTESPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVALVDGYFRLTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLHRLILTVAHRNPAFSNGPRGLRLRKFPITQQPGAFVLDGWGRSFASLGDLRLALQGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSSPELATLTRQCLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQEKYQGQVPSVFSVC
What is the function of this protein?
Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:11070174).  Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (By similarity).  Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:22859374).  The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (By similarity).  In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (By similarity).  In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (By similarity).  Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (By similarity).
What are the official names of this protein?
Non-receptor tyrosine-protein kinase TYK2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Protein: SSB1_SALTI
Sequence: MASRGVNKVILVGNLGQDPEVRYMPSGGAVANLTLATSESWRDKQTGEMKEQTEWHRVVMFGKLAEVAGEYLRKGSQVYIEGQLRTRKWTDQSGQERYTTEINVPQIGGVMQMLGGRQGGGAPAGGQQQGGWGQPQQPQQPQGGNQFSGGAQSRPQQSAPAPSNEPPMDFDDDIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein 1, SSB 1.
Protein: EFTS_AYWBP
Sequence: MKITAEMIKDLRQKTHAGMNECHKALQQTEGNIEKAIVFLREKGIIKAAQKQGRVTSEGITNIVFAGNNAFLYEINSETDFVSKNEHFQQLVKMLGEIILKKQLSNVKDLLAFNYQNKTVQELLFEKTSVLGENITLKRVLKVTKKPQESFGIYKHQGGRISVLVVLKNDCPSVSEDIAMHIAASKPQFLTPDKVDPTFLAEEKKILHKQAAKELSDKPAQMIEKIIENRLGKMLKDMCLSEQPFVKNADQKVKDYLKANNTDVVYYVRWEMGN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O51M1_HUMAN
Sequence: MSVQYSLSPQFMLLSNITQFSPIFYLTSFPGLEGIKHWIFIPFFFMYMVAISGNCFILIIIKTNPRLHTPMYYLLSLLALTDLGLCVSTLPTTMGIFWFNSHSIYFGACQIQMFCIHSFSFMESSVLLMMSFDRLVAICHPLRYSVIITGQQVVRAGLIVIFRGPVATIPIVLLLKAFPYCGSVVLSHSFCLHQEVIQLACTDITFNNLYGLMVVVFTVMLDLVLIALSYGLILHTVAGLASQEEQRRAFQTCTAPLCAVLVFFVPMMGLSLVHRFGKHAPPAIHLLMANVYLFVPPMLNPIIYSIKTKEIHRAIIKFLGLKKASK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 51M1, Odorant receptor HOR5'beta7, Olfactory receptor OR11-40.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCH1_PORGI
Sequence: MTEIEKEEACSRLQQHYAQVLSLLGEDPKREGLLKTPLRVAKAMQFLTKGYNEDPEAILRAAMFEEDYQQMVIVKDIDFFSMCEHHMLPFFGKAHVGYIPNRYITGLSKLPRVVDVFARRLQVQERLTTQIKECIQNTLNPLGVIVVIEAQHMCMQMRGVEKQNSLTTTSDFTGAFEESTTREEFLNLIGRRR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: CRYAA_RABIT
Sequence: MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVQSGLDAGHSERAIPVSREEKPSSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.  Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: RPO5_MIMIV
Sequence: MEPNKSILQIMKSNSDKVKIILGNIITMLGNRIYIDNNGDSKPLLDPTNAFKNMEERGDNVFIIKADNGDLYAVKVIFQKITAISKQSVISEFLDEYETYKKIIVTKDYTGKIDTFILRNSGQIFKEHEFLADLLSNEFQPRFQLLSPSEMESVKTEYNANPYTLKKIVRSDPIVRYFALKKNDIIRIIRPSATSGQGIDYRVVV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Virion.