PharMolix/UniProtQA huggingface dataset:
Protein: SCAL_DROME
Sequence: MKNITSSSTCSTGLLQLQNNLSCSELEVAEKTEQQAVGPGTIPSPWTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKVQFWQPGLQPSTSQDFYDYSIKPFPQPPYPAGKTSTAVSGDETGIPPSQLPWEGRAIATHKFRLLEFTAFMEIQRDEIYHRHLFVQLGGKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCWADLNTDLTTGSETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGTTHHIYRLIKE
What is the function of this protein?
Transcription factor which plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein.  The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam.  Sd promotes nuclear localization of Yki.  Involved in the regulation of cell-specific gene expression during development, particularly in the differentiation of the nervous system.  When in combination with vestigial (vg) it acts as a transcriptional activation complex that regulates gene expression in the wing.  Binding to vg switches the DNA target selectivity of sd.  Required autonomously for cell proliferation and viability within the wing blade.  Required for proper sensory organ precursor (SOP) differentiation at the wing margin; required for correct expression of sens.
What are the official names of this protein?
Protein scalloped.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL10_SYNPW
Sequence: MGRTLESKQQIVEELKQLLGEAEMALVLDYQGLSIKEMSDLRTRLQAANGVCKVTKNTLMRRAIDGDSAWSNLDSLLTGTNAFVLVKGDVGGAVKAVQAFQKDTKKSETKGGLFEGKLLSQDEIKAIGDLPSKEALMAQIAGAINAVATKVAVGINEVPSGLARALKQHAESGEG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RL27_MESH2
Sequence: MAKTKAGGSTKNGRDSAGRRLGQKIGDGQFALTGSIIYRQRGTRIYPGKNVGIGNDDSLFALVDGIVKFQKIRKRKYATVVMAK
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: Y0067_DICDI
Sequence: MDQNEANIYNENNENNENNENENCQNEPIRIKIII
What are the official names of this protein?
Putative uncharacterized protein DDB_G0294382.
Protein: TPM2_PODCA
Sequence: MSGEEKLGKLRAKLKEITEQIDDADQKKVEAKHALVDSLARLEKNEVEVNSAKRRIKLIEKDLEDSSERLKVAEEKLIKVEAEEKKIEEARNLLEEAESADDEKMYNIEEEFKESKRTLESNETKYIEAQRKGVVISRDVEKTRDKADTLEKRVAVLEQTIASAGESLVELEEREGESSEREEINEEKLIFLAGQFKESEVRAEAAERSCNVLERNIFETENEINTWIQKRKEIEDEMIEMDTVADEPDDE
What are the official names of this protein?
Tropomyosin-2.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
Protein: GPAA1_MOUSE
Sequence: MGLLSDPVRRRALARIVLRLNTPLCVLSYVAGIAWFLALAFPPLTQRTYMSENAMGSTMVEEQFVGGDRARSFARDFAAHRKKPGALPVAWLERSMRSVGLEVYTQSFSRKLPFPDETHERYMVSGTNVYGILRAPRSASTESLVLTVPCGPDATNSQAVGLLLALAAHFRGQIYWAKDIIFLVTDHDLLGTEAWLEAYHDINVTGIQSSPLQGRAGAIQAAVALELSSDVVTSLDVTVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPQDWTSLEGPLQGLQTLLLMVLRQASGRPHGPHGLFLRYGVEALTLRGINSFRQYKYDLATVGKALEGMFRKLNHLLERLHQSFFFYLLPALSRFVSIGLYMPATGFLLLVLGLKALELWMQLHQAGVNPEEAGKAPSPGTPLLPTQGVGLASLTAPLLISQAMGLALYFLPVLGQHLATQHFPVAEAEAVVLTLLAIYVAGLALPHNTHRVVNSQVPDRGWMALKLVALIYLALQLGCIALLNFSLGFLLAATMVPAAALAKPHGPRTLYAALLVVTSPAVTLFGSLFLWRELLEVPLSLAEGWQLFLTALAQGVLEHYTYGALLFPILALGLYPCWLLFWNVLFWK
What is the function of this protein?
Essential for GPI-anchoring of precursor proteins but not for GPI synthesis.  Acts before or during formation of the carbonyl intermediate.
What are the official names of this protein?
Glycosylphosphatidylinositol anchor attachment 1 protein, GPI anchor attachment protein 1, GAA1 protein homolog, mGAA1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HN1BB_DANRE
Sequence: MFTDMVSKLTSLQQELLSALLDSGVTKDVLVQALEDLCPCPAEFGIKIEKPLSPSSANGGSDCGDSKPVFLTLTGAQGKGGKLSGDEGSEDGDDFDTPPILRELQSLNTEEAAEQRAEVDRMLSEDPWRVARTIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTAKRAALYTWYVQKQREIDRQFDRVQGSDPSDSASQDQVLFFFPEFNHGGHSSGAAGGSGAAVGDEGEPGSKRMRRNRFKWGPASQEILYQAYERQKNPSKEEREALVEECNRAECVQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDTYTPHMNPLLSHTASLSHHHSSESKLRYSQQAASEVTSSTTISHPSVLQQVSPGGLDHCHGLLSTDAKMISVSGGVLPPVSTLTNIHSLSQSSHHHHHHHHQQAQSLIMSLAAQSLTSPQSQSVPVINSVSGLTTLQPMQFPQSSSLTQLTTAHISQQPFAQSHMYSPKQEAGQFSHPSRYSTMDSSTITHLGSSKQCPLQAW
What is the function of this protein?
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity).  Acts downstream of hnf1ba but is not required for induction of rhombomere r5/r6 gene expression in the hindbrain.
What are the official names of this protein?
Hepatocyte nuclear factor 1-beta-B, HNF-1-beta-B, HNF-1B-B, Hepatocyte nuclear factor 1-beta-like, Hepatocyte nuclear factor 1-gamma, HNF1g.
What is the protein family that this protein belongs to?
Belongs to the HNF1 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LRGB_BACCZ
Sequence: MASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNTGGKMISFFLEPATIAFAIPLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVIVYALGALFLKTFRVKHPIAKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA.  The LrgAB and CidA proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. LrgB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TSAD_RICAE
Sequence: MIKILGIESSCDDTAVSIITKNREILSNIIISQNTEHAVFGGVVPEIAARSHLSHLDKALKNVLKESNTKLTDISTIAATSGPGLIGGVIVGSMFAKSLSSALKKPFIAINHLEGHALTARLTDNIPYPYLLLLASGGHCQFVAVLGLGKYKILGSTIDDAVGEAFDKVAKMLNLAFPGGPEIEKRAKLGDPHKYKFPKPIINSGNCNMSFSGLKTAVRTLIMNLKEINDTVINDIAASFQFTIGEILSSKVQDAIRAYEQITNNFDKKNIVIAGGVAANKYLQKILSSCAKIYGYRLIYPPIHLCTDNAAMIAYAGLERYNNKLFTPLNFCPKARWSLEDISN
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPAG8_HUMAN
Sequence: METNESTEGSRSRSRSLDIQPSSEGLGPTSEPFPSSDDSPRSALAAATAAAAAAASAAAATAAFTTAKAAALSTKTPAPCSEFMEPSSDPSLLGEPCAGPGFTHNIAHGSLGFEPVYVSCIAQDTCTTTDHSSNPGPVPGSSSGPVLGSSSGAGHGSGSGSGPGCGSVPGSGSGPGPGSGPGSGPGHGSGSHPGPASGPGPDTGPDSELSPCIPPGFRNLVADRVPNYTSWSQHCPWEPQKQPPWEFLQVLEPGARGLWKPPDIKGKLMVCYETLPRGQCLLYNWEEERATNHLDQVPSMQDGSESFFFRHGHRGLLTMQLKSPMPSSTTQKDSYQPPGNVYWPLRGKREAMLEMLLQHQICKEVQAEQEPTRKLFEVESVTHHDYRMELAQAGTPAPTKPHDYRQEQPETFWIQRAPQLPGVSNIRTLDTPFRKNCSFSTPVPLSLGKLLPYEPENYPYQLGEISSLPCPGGRLGGGGGRMTPF
What is the function of this protein?
Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity).  Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity).  Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270).  May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252).
What are the official names of this protein?
Sperm-associated antigen 8, HSD-1, Sperm membrane protein 1, SMP-1, Sperm membrane protein BS-84.
What is the protein family that this protein belongs to?
Belongs to the SPAG8 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium axoneme. Note=In mature sperm cells, detected in the acrosomal region of the head and in the middle piece of the tail (By similarity). Localized to the nucleus and cytoplasm of spermatocytes and round spermatids while, in elongating spermatids, expressed in the cytoplasm but not in the nucleus (By similarity). During the cell cycle, localized on the microtubule-organizing center (MTOC) during prophase. In metaphase, extends along spindle microtubules. In anaphase, detected on the astral microtubules and mid-zone. In telophase, remains at the mid-zone. After cytokinesis, returns to the MTOC (PubMed:19548270). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By similarity).
Protein: T161B_HUMAN
Sequence: MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKTKKDRKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLVTEVYYNFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQSPVSKLTFKFFLAIFCSFIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESIPLMTEATFDTLRLWLIILLCALRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNHSWGIYPESISTLPVDNSLLSNSVYSELPSAEGKMKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA
What is the function of this protein?
Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival (By similarity).  Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm (By similarity).
What are the official names of this protein?
Transmembrane protein 161B.
What is the protein family that this protein belongs to?
Belongs to the TMEM161 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PUP12_ARATH
Sequence: MLLLKEEDEGRRRTSVPTQLMKLNRSQWWILVFISIFFLISAQAISVLLGRFYYNEGGNSKWISTLVQTGGFPILYLPLSLLPASQSSSSSSSSSSFKTLVWIYLSLGFAIGLDNFLYSVGLLYLSASTYSILCASQLAFNGVFYYYINSQKITCLIFFSVLFLSISAVLVSLDDDSNSPSGDSKWSYLIGCFCAVFASLIYSLQLSLMQFSFEKVLKSETLSMVLEMQIYTSLVASCVAVIGLFASGEWMLLSVEMEEFQEGQVIYVLTLVGAAVSCQLGCVGAVSLIFLVSSLFSNLISTLSLIVTPLAAIAVFHDKLTEVKMVAMPIAFTGFTFYIYQNYLDDLKVQRAREAQAE
What are the official names of this protein?
Putative purine permease 12, AtPUP12.
What is the protein family that this protein belongs to?
Belongs to the purine permeases (TC 2.A.7.14) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CSR2B_HUMAN
Sequence: MDSSIHLSSLISRHDDEATRTSTSEGLEEGEVEGETLLIVESEDQASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFFRFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHWTFLLGNRKKTSTWWSTVAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEKLSASTLKIKAASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGFLDRSTSSTPVKFISRGRRPDVILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFSAPGTPASHSATPSLLSEADLIPDVMPPQALFHDDDEMEGDGVIDPGMEYVPPPAGSVASGPVVGVRKKVRGPEQIKQEVESEEEKPDRMDIDSEDTDSNTSLQTRAREKRKPQLEKDTKPKEPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLFDLDQVVNAALLLVDGIYGAKEGGISRLPAGQATYRTTCQDFRILDRYQTSLPSRKGFRHQTTKFLYRLVGSEDMAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHRSDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKVIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR
What is the function of this protein?
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.  May function as a scaffold for the ATAC complex to promote ATAC complex stability.  Has also weak histone acetyltransferase activity toward histone H4.  Required for the normal progression through G1 and G2/M phases of the cell cycle.
What are the official names of this protein?
Cysteine-rich protein 2-binding protein, CSRP2-binding protein, ADA2A-containing complex subunit 2, ATAC2, CRP2-binding partner, CRP2BP, Lysine acetyltransferase 14.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly nuclear.
Protein: RR7_PSINU
Sequence: MSRQSETKKRTAKSDPIYRNRSVSMFINHILKDGEKSLAHKILYRAMKQIKRKTKKNPLSVLRQAVYRVTPNVAVKSRRVGGSNYQVPVEVKPARGKALAIRWIVGASRNRSGRSMASKSSYELIDAARNTGSAIRKKEETHKMAEANKAFAHLR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CDKC2_ORYSJ
Sequence: MAVAAPGQLNLDESPSWGSRSVDCFEKLEQIGEGTYGQVYMAKETETNEIVALKKIRMDNEREGFPITAIREIKILKKLHHQNVIQLKEIVTSPGPERDEQGKPIEGNKYKGSIYMVFEYMDHDLTGLADRPGMRFTVPQIKCYMRQLLTGLHYCHVNQVLHRDIKGSNLLIDNEGNLKLADFGLARSFSSDHNGNLTNRVITLWYRPPELLLGSTRYGPAVDMWSVGCIFAELLNGKPILTGKNEPEQLSKIFELCGTPDELIWPGVTKMPWYNNFKPQRPMKRRVKESFKHFDQHALDLLEKMLTLDPSQRISAKDALDAEYFWTDPLPCDPKSLPKYEASHEFQTKKKRQQQRQAEEAAKRQKLQHPPPHSRLPPIQNPGQPHQIRPGQPMHNAPPVAAGPSHHYAKPRGPGGPNRYPQGGNQGGYNPNRGGQGGGYGSGPYPQQGRGPPPYPGGGMGGAGGPRGGGGSGYGVGGPNYQQGGPYGASGPGRGPNYNQGGSRNQQQYGNWQ
What are the official names of this protein?
Cyclin-dependent kinase C-2, CDKC;2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: XYLA_STRDI
Sequence: MSYQPTPEDKFTFGLWTVGWQGRDPFGDATRGALDPAESVRRLAELGAHGVTFHDDDLIPFGATDSERAEHIKRFRQGLDETGMKVPMATTNLFTHPVFKDGGFTANDRDVRRYAVRKTIRNIDLAVELGAQTYVAWGGREGAESGAAKDVRVALDRMKEAFDLLGEYVTSQGYDTPFAIEPKPNEPRGDILLPTIGHALAFIDGLERPELYGVNPEVGHEQMAGLNFPHGIAQALWAGKLFHIDLNGQSGIKYDQDLRFGPGDLAAAFWLVDLLESAGYEGPRHFDFKPPRTEDFDGVWASAAGCMRNYLILKERAAAFRADPEVQEALRAARLDELAQPTAGDGLQALLPDRSAFEDFDPDAAAARGMAFERLDQLAMDHLLGARG
What is the function of this protein?
Involved in D-xylose catabolism.
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURNU_ECOLI
Sequence: MSKLIVPQWPQPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADCLPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILAWLGPAIGPRAFEVGGEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine (PubMed:31978345).  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345).  Also has adenosine deaminase activity (PubMed:31978345).  May also act as a polyphenol oxidase: able to oxidize syringaldazine and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) in vitro (PubMed:16740638).
What are the official names of this protein?
Purine nucleoside phosphorylase YfiH, Adenosine deaminase YfiH, Polyphenol oxidase YfiH, S-methyl-5'-thioadenosine phosphorylase YfiH.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
Protein: PFF1_AJECH
Sequence: MASSRAQRFNPIAFTPWPVTCITTIVYLALLIPILVINLVVPSAPETNPKGVNLTEAWRDLQHLTGGFHPYNSRRNDEVHEWLLSRINSIIRPTVEAGQRSSATDNLPEVFVFDDNRSNLTYSNGGVGKTSIVGVYFESTNIIVYIRGSEDDSENWRERSNGKPKGKGGVLVNAHYDSVSTGYGATDDGIGVVSLLQLLRYFTTPGNNPRKGLVLLFNNGEEDYLNGAHVFSQHPLSNFTHTFLNLEDTEVTRFYGNTKHPFGSVLAADGFKMGLLRSQTDYVVFNGILGLRGLDLAFIAPRSRYHTDQDDTRHTSIDSLWHMLSASIGTTEGLVSYTGMDFDGKSKGQNKVNSGAGSLGVWFDMFGTAFAVFRLHTLFAISVALLVIAPLVIFITSVILSKTDRMYLFSMSKSLEGTGDQVSLRGLRGFSRTPIILVIATTIPICLAYLLEKVNPYIVHSSQFSVWSMMFSAWIFLAWFLACAADFFRPSALHRAYSYTWIFVATWIMLVINTVYANQKGIAAGYFLLFYFAGAFLATWISYLELFALPRKGDFARQTTGRRPSSLSSRLLTSSADELRSNASPSTAEFPGAAGEDTDPTESTSLLRGQRTTFANYRTSGPGGAAEETDEREDINKGGTFEHEQSWSWTLPRWTWVLQLLLLAPIVLILVGQLALFLTASMCQVGSDGVSTFVVYLACAVFTTLLCIPLFPLIHRFTYHIPTFLFLVFIGTLIYNLVAFPFSPANRLKTFFIQEVDLDNGSSTVSLTGIQPYLTEAINSIPSAAGQNITCDKTTPFGMLERCSWSGLSPNVLGQGRERDTEIVPDKWITYNITKTVGKNKARIEISGRNTRACKLKFDRAVANFQVSGSAVDHRMPPTSRQGPGVIPALDEVRLYAPSWIAISKAADGLVEASHSFTIQ
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: SLS4_TRYBB
Sequence: MISYPFFSLSPPGLVPPPMAVPPVEMYSGSFWNRMRKPLPLRTQVIRFTVVFVIVSFILAVALQITHERMPDPKVTKPLPDLGFELLTKVPGMYVLADCCIGFLNILSVFTAFKLYLLHRHCVGSGEPELPCNIPGVSRFFLSVWLCKENCRIELRNIHTIAWIRFITSYALLLLFRSAVIVMTSLPAPDDLCQDPPKIENPVKNVILTVLTAGGGSIHCGDLMYSGHTVILTLHLMFHWIYGAMVHWSFRPVVTVVAIFGYYCIVASRFHYTDDVLVAIYLTIATFIAVGHNADGAPWQLQLFIRWWPCCGANSREVTEDSQPVMVAFKSEELDEMNGVLEGRQKKHGGVGDGESLMFKCGAYV
What is the function of this protein?
Bifunctional sphingomyelin (SM)/ethanolamine phosphorylceramide (EPC) synthase with minimal inositol phosphorylceramide (IPC) synthase activity (PubMed:18699867, PubMed:20457606, PubMed:19545591, PubMed:21899277).  Specificity is likely to be defined by residues in the lumenal catalytic domain that interact with the polar head groups of the phospholipid donors (PubMed:21899277).  SM is synthesized by both stages of the parasite life cycle, bloodstream forms (BSF) and procyclic forms (PCF), by transferring the phosphoryl headgroup from a 1,2-diacyl-sn-glycero-3-phosphocholine to an N-acylsphing-4-enine (ceramide) or an N-acylsphinganine (dihydroceramide) with release of 1,2-diacyl-sn-glycerol (PubMed:18699867).  Also catalyzes the reverse reaction, production of ceramide from sphingomyelin (PubMed:21899277).  EPC is synthesized by transferring phosphoethanolamine from a 1,2-diacyl-sn-glycero-3-phosphoethanolamine to ceramide or dihydroceramide by BSF and PCF, while IPC is confined to PCF (PubMed:18699867).  The ceramide/dihydroceramide ratios are skewed towards dihydroceramide in PCF parasites and ceramide in BSF parasites, this is likely due to differential expression and/or regulation of dihydroceramide desaturase, the enzyme responsible for converting dihydroceramide to ceramide (PubMed:18699867).
What are the official names of this protein?
Phosphatidylcholine:ceramide cholinephosphotransferase 4, TbSLS4, Ethanolamine-phosphorylceramide synthase, EPC synthase, Sphingomyelin synthase, SM synthase.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelin synthase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: OBG_YERPP
Sequence: MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDIYLLADENLNTLIDYRFVKSFRAERGQNGQSRDCTGKRGKDITIKVPVGTRVLDQGTGEIVGDMVRHGQRLMVAKGGFHGLGNSRFKSSVNRAPRQKTMGTEGETRELMLELLLLADVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVRMDYEQSFVIADIPGLIEGASDGAGLGIRFLKHLERCRVLLHLVDLAPIDESDPAENAKVIVNELQQYSENLAEKPRWLVFNKIDLIDPEEAEKRAKAIVETLGWEGKYYMISAANRDNVNALCWDVMSFLNSQPKAMAIAESVPEKVEFMWDDYHREQLAEVEAEAEDDWDDDWDEEDDDGVEIIYER
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_STRCO
Sequence: MADVPADLAAVWPRVLEQLLGEGRGQGVESKDEHWIRRCQPLALVADTALLAVPNEFAKGVLEGRLAPIVSETLSRECGRPIRIAITVDDTAGEPAGPAPQAPQSPPSRPQHRYEEPELPAPGQGGREEYRDRDEYEGYGRNRADQLPTARPAYPQEYQRPEPGSWPRPAQQDDYGWQQQRLGFPERDPYASPNQEPYGQEPPPPYSHENRTSYQQDYRPQPPERPSYDAQRGDYEQARGEYEQPRGDYDKPRGDYDQQRGDYDQRGPRRDLPEPPPGSGHVHRGGPVGPGPATGAPGPLAAQPAPATGPGEPTARLNPKYLFDTFVIGASNRFAHAAAVAVAEAPAKAYNPLFIYGESGLGKTHLLHAIGHYARSLYPGTRVRYVSSEEFTNEFINSIRDGKGDSFRKRYREMDILLVDDIQFLADKESTQEEFFHTFNTLHNANKQIVLSSDRPPKQLVTLEDRLRNRFEWGLITDVQPPELETRIAILRKKAVQEQLNAPPEVLEFIASRISRNIRELEGALIRVTAFASLNRQPVDLGLTEIVLKDLIPGGEDSAPEITSTAIMGATADYFGLTVEDLCGTSRGRALVTARQIAMYLCRELTDLSLPKIGALFGGRDHTTVMHADRKIRNLMAERRSIYNQVTELTNRIKNG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.