PharMolix/UniProtQA huggingface dataset:
Protein: NDHO_ACAM1
Sequence: MAVKKGSLVRIVPEKFENSVEAKASDRRLPPYVFEGTGEVLEIKGDYAQIQFRVPVPTVWLRVDQLEAA
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit O, NAD(P)H dehydrogenase I subunit O, NDH-1 subunit O, NDH-O.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhO subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: A1MA2_LOXDE
Sequence: WIMGHMVNAIAQIDEFVNLGANSIETDVSFDKNANPEYTYHGIPCDCGRTCTKSEKFNVFLQGLQKATTPGDSKYQEKLVLVVFDLKSSSLYDNQASDAGKKLAKSLLQNYWKNGNNGGRAYIVLSIPNLAHYKLITGFKETLKTEGHPELMEKVGYDFSGNDDIDQVAKAYKKAGVTGHVWQSDGITNCLPRGLDRVKQAVANRDSSNGFINKVYYWTVDKRSTTRGALDAGVDGIMTNYPDVIADVLSESAYKSKFRIATYEDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LdSicTox-alphaIB3aii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LAP1_AJECG
Sequence: MKFPSLLSLGVAASTTIVAAVPDQKPIGDIIEDVHLGKFLIELGPGDTRWVTEEEKWGLRRDGRRFFDITAEAGQGVFPKTFAQTTVTFPTELQNVAHVKKLASSLSKNRLQTFLTKFTSFYTRYYKSESGRQSAIWLFEQIEKTIQESSATEARVEKFEHPWGQFSIIATIPGQTNKTVVVGAHQDSINLLMPSILPAPGADDDGSGTATILEALRVLLKSEAVTQGKAPNTVEFHWYSAEEAGLLGSQAVFAQYKQDNRDVKSMLQQDMTGYSKGTTNAGHADSVGIITDFVDEGLTNFIKKVVTGYCGISYVLTKCGYACSDHASASRYGYPSAFVIESKFEYSSKLIHSTRDEVSSLDFDHMLQHAKMTLGLVYELAFADL
What is the function of this protein?
Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.
What are the official names of this protein?
Leucine aminopeptidase 1, Leucyl aminopeptidase 1, LAP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28E subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CMOA_PSYCK
Sequence: MSHTMSQSQPTTVKHDTLFTTPLDKAARFSFDEQVVACFPDMIRRSVPGYGQVLAMLPIFARRHCKYRQQSDSGQRVSRIYDLGCSLGAASMTLAGEFEPQDLQIKAIDISPAMTTEATTLLNDNYPEHDIEVITADIRDIELEPCDMVILNLTLQFLPAADRVAVLEKIYVALSEGGILVLTEKTHAFDEQYDAWLVERYYDFKRANGYTEMEISGKRNALENVLITDTLDEHHARLSDVGFQRHLTWFQFLNFVSIVAFK
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: EEPD1_BOVIN
Sequence: MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLMAEQQPHHLATAAAVPLTPRVNINTATPAQLMSVRGLTEKMAVSIVDYRREHGPFRSVEDLVRMGGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCVELNQPILPNIRKWKGPRGCWKAVVSETPSTQLQKGAGFAGFLWDTAAGVELRDAAWQESSPGNGHGKPVGPSPYLARFKVGSHDLTLVNLHLATLTLPGGENLSKNHSDSHRWASFTQTLQETLKGEKDVIVLGDFGQGPDSSDYDILRKEKFHHLIPAHTFTNISTKNPQGSKALDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWTRKEGPRSGNGLTLERSEANIKHER
What are the official names of this protein?
Endonuclease/exonuclease/phosphatase family domain-containing protein 1.
Protein: RL9_CELJU
Sequence: MEVILLDKVGKLGAIGDKVTVKSGYGRNYLLPQGKAVAATEKNIADFEARRAELEATAAAKISEATARAEKLASLEVTIAANAGTEGRLFGSIGTRDIAEAITAAGVAVAKSEVRLPQGVLREVGQFEIDIQLHAEVVQVVKLVVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: SELU_SALSV
Sequence: MNDGTDYRALLLADTPLIDVRAPIEFEQGAMPGAINLPLMMDDERAAVGTCYKRQGADAALALGHRLVCGDIRQQRLEAWKAAYQRFPNGYLCCARGGQRSHIVQRWLQETGIDCPLIEGGYKALRQTAIQATWQLAQKPILLIGGCTGSGKTQLVRQQPNGVDLEGLARHRGSSFGRTLKPQLSQASFENKLAVELLKINARQTLKRWVLEDEGRTIGANHLPECLRERMVQAPIAVVEDPFSLRLERLREEYFIRMHHDFTHAYGDEAGWQAYSEYLHHGLFAIRRRLGLQRFAELTDTLDRALAEQLSSGSTDGHMAWLVPLLNEYYDPMYRYQLEKKAANIVFRGTWQDVANWLKAQ
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: RPPH_POLAQ
Sequence: MLDREGYRPNVGIVLLNSRNEVFWGKRVGQHSWQFPQGGIQHGESPEQAMYRELHEEVGLLPEHVQIIGRTRDWLRYDVPEEYLRRQHATRVHRAAYRGQKQIWFLLRLVGLDSDIQLRASEHPEFDAWRWVPFWIQLDAVIGFKREVYELALSELARYLSRGVRMHQLAWGSPLDLLQSFYSKGEEGSPESSKTDKSK
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: RS15_STUS1
Sequence: MALSVEEKAQIVNEYKQAEGDTGSPEVQVALLTANINKLQDHFKANGKDHHSRRGLIRMVNQRRKLLDYLKGKDTTRYSALIGRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: ASSY_BACC2
Sequence: MEKKKVVLAYSGGLDTSVAIKWLQEKNYDVIALCLDLGEGKDLGFVKEKALSVGAIKSYMVDVQEEFANEYALMAMQAHTLYEGKYPLVSALSRPLIAKKLVEIAEQEGATAVAHGCTGKGNDQVRFEVSIQALNPYLEVIAPVREWKWSREEEIAYAKENDVPIPIHLDSPFSIDQNLWGRSNECGILEDPWAAPPEEAYEMTLALEDTPNKPEFVEIGFEAGVPTTLNGTAYSLAELIKTLNALAGKHGVGRIDHVENRLVGIKSREVYECPAAMTLITAHKELEDLTHVKEVAHFKPVIEQKITELIYNGLWFSPLKQALHAFLQETQKNVTGTVRVKLFKGHAIVEGRKSEYSLYDEKLATYTAQDEFNHDAAVGFISLFGLPTKVYSQVNQKKVEA
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2RY4_XENLA
Sequence: MTEDIMATSYPTFLTTPYLPMKLLMNLTNDTEDICVFDEGFKFLLLPVSYSAVFMVGLPLNIAAMWIFIAKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADKNNWPFGEVLCKLVRFLFYANLYSSILFLTCISVHRYRGVCHPITSLRRMNAKHAYVICALVWLSVTLCLVPNLIFVTVSPKVKNTICHDTTRPEDFARYVEYSTAIMCLLFGIPCLIIAGCYGLMTRELMKPIVSGNQQTLPSYKKRSIKTIIFVMIAFAICFMPFHITRTLYYYARLLGIKCYALNVINVTYKVTRPLASANSCIDPILYFLANDRYRRRLIRTVRRRSSVPNRRCMHTNHPQTEPHMTAGPLPVISAEEIPSNGSMVRDENGEGSREHRVEWTDTKEINQMMNRRSTIKRNSTDKNDMKENRHGENYLPYVEVVEKEDYETKRENRKTTEQSSKTNAEQDELQTQIDSRLKRGKWQLSSKKGAAQENEKGHMEPSFEGEGTSTWNLLTPKMYGKKDRLAKNVEEVGYGKEKELQNFPKA
What is the function of this protein?
Receptor for extracellular ATP, UTP, CTP, GTP and ITP.  The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.  May play a key role in the early development of neural tissue.
What are the official names of this protein?
P2Y purinoceptor 4, P2Y4, P2Y purinoceptor 8, P2Y8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RHAM_SALSV
Sequence: MIRKAFVMQVNADAHEEYQRRHNPIWPELEAVLKSHGAHHYAIYLDQERNLLFATVEIESEERWNAVASTDVCQRWWKHMRDVMPANPDNSPVSAELKEVFYLQ
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRE_ARATH
Sequence: MSTTEPSPENDRDPQPTTISTPTSTNAKLLKKIPAIPFRHSDKEGEDEQAKTDEVTTELAGEGPMSHDSPEILAPSSLGLNHIRTKSSPAPSPLRFSSATPLISPGQDDKDVAKEKPRVGVVDARADARARWPIPPHQPDQGKKVQWSQSKSQRVPANSNPGVESTHVGLAKETQSPRFQAILRVTSGRKKKAHDIKSFSHELNSKGVRPFPVWRSRAVGHMEEIMAAIRTKFDKQKEDVDADLGVFAGYLVTTLESTPESNKELRVGLEDLLVEARQCATMPASEFWLKCEGIVQKLDDKRQELPMGGLKQAHNRLLFILTRCNRLVQFRKESGYVEEHILGMHQLSDLGVYPEQMVEISRQQDLLREKEIQKINEKQNLAGKQDDQNSNSGADGVEVNTARSTDSTSSNFRMSSWKKLPSAAEKNRSLNNTPKAKGESKIQPKVYGDENAENLHSPSGQPASADRSALWGFWADHQCVTYDNSMICRICEVEIPVVHVEEHSRICTIADRCDLKGINVNLRLERVAESLEKILESWTPKSSVTPRAVADSARLSNSSRQEDLDEISQRCSDDMLDCVPRSQNTFSLDELNILNEMSMTNGTKDSSAGSLTPPSPATPRNSQVDLLLSGRKTISELENYQQINKLLDIARSVANVNVCGYSSLDFMIEQLDELKYVIQDRKADALVVETFGRRIEKLLQEKYIELCGLIDDEKVDSSNAMPDEESSADEDTVRSLRASPLNPRAKDRTSIEDFEIIKPISRGAFGRVFLAKKRATGDLFAIKVLKKADMIRKNAVESILAERNILISVRNPFVVRFFYSFTCRENLYLVMEYLNGGDLFSLLRNLGCLDEDMARIYIAEVVLALEYLHSVNIIHRDLKPDNLLINQDGHIKLTDFGLSKVGLINSTDDLSGESSLGNSGFFAEDGSKAQHSQGKDSRKKHAVVGTPDYLAPEILLGMGHGKTADWWSVGVILFEVLVGIPPFNAETPQQIFENIINRDIPWPNVPEEISYEAHDLINKLLTENPVQRLGATGAGEVKQHHFFKDINWDTLARQKAMFVPSAEPQDTSYFMSRYIWNPEDENVHGGSDFDDLTDTCSSSSFNTQEEDGDECGSLAEFGNGPNLAVKYSFSNFSFKNLSQLASINYDLVLKNAKESVEASNQSAPRPET
What is the function of this protein?
Modulates root tip growth.  May play a common role in the tip growth of plant cells.
What are the official names of this protein?
Probable serine/threonine protein kinase IRE, Protein INCOMPLETE ROOT HAIR ELONGATION, AtIRE.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Protein: ATPB_PARD8
Sequence: MGEIKGYISQVIGPVVDIHFDYGTEETVTLPRIHDAMEISRPNGKILIVEVQQHIGENTVRTVAMDTTDGLRRGMEAVSYGMPITMPTGDQVKGRLMNVTGDPIDGMAQLTKDGALPIHREPPKFEDLTTTQEVLYTGIKVIDLLEPYAKGGKIGLFGGAGVGKTVLIMELINNIAKKNNGFSVFAGVGERTREGNDLLREMIQSGVIRYGEEFKKSMEAGNWDLSKIDYDELAKSQATLVFGQMNEPPGARSSVALSGLTIAESFRDKASEGERKDILFFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGAMQERITSTKKGSITSVQAVYVPADDLTDPAPATTFTHLDATTVLSRKITELGIYPAVDPLESTSRILDPLIVGKEHYDTAQRVKQILQRNKELQDIISILGMEELSDEDRLTVNRARRVQRFLSQPFSVAEQFTGVPGVMVSIEDTIRGFKMIMDGETDDIPEQAFLNVGTIEDVLEKAKQLKEQAN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HIS7_BURP0
Sequence: MRVAQVVRNTSETQISVKIDLDGTGRQKLATGVPFLDHMLDQIARHGLVDLDIEAHGDTHIDDHHTVEDVGITLGQAVAKAVGDRKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAHHQLETVFKAFGRALRMAVELDERAAGQIPSTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAV1_ARATH
Sequence: MESSSVDESTTSTGSICETPAITPAKKSSVGNLYRMGSGSSVVLDSENGVEAESRKLPSSKYKGVVPQPNGRWGAQIYEKHQRVWLGTFNEEDEAARAYDVAVHRFRRRDAVTNFKDVKMDEDEVDFLNSHSKSEIVDMLRKHTYNEELEQSKRRRNGNGNMTRTLLTSGLSNDGVSTTGFRSAEALFEKAVTPSDVGKLNRLVIPKHHAEKHFPLPSSNVSVKGVLLNFEDVNGKVWRFRYSYWNSSQSYVLTKGWSRFVKEKNLRAGDVVSFSRSNGQDQQLYIGWKSRSGSDLDAGRVLRLFGVNISPESSRNDVVGNKRVNDTEMLSLVCSKKQRIFHAS
What is the function of this protein?
Binds specifically to bipartite recognition sequences composed of two unrelated motifs, 5'-CAACA-3' and 5'-CACCTG-3'.  May function as negative regulator of plant growth and development.
What are the official names of this protein?
AP2/ERF and B3 domain-containing transcription factor RAV1, Ethylene-responsive transcription factor RAV1, Protein RELATED TO ABI3/VP1 1.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. RAV subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURL_META3
Sequence: MDLNDLKFIEEQLGRKPNDVEIGMFENLWSEHCSYRSTKKLLSMFGKTVKENQNIVVGPGDDAALIKIDDETDLCVAMAMESHNHPSYIDPYNGAATGVGGIVRDIISMNAKPIALLNALRFGDINGEEKDKVRWLVEGVVDGIRDYGNRIGVPNVGGECEFDKSYDYNNLVNVVCIGLVKEGDIVTGKAKETDLTLILVGSTGRDGIGGASFASKDLTSESEGDRPSVQIGDAFTEKCVIDSTLEACATKKVKAIKDLGAAGITSSCSELCYSGGVGAELYLENVILRDEGMTAYEIMVSESQERMLLAVEKGSEEEIIKIFEKYELPVSIIGKTTDTKRFFVKMNDEVVVDLPLDLLCEATLTDSEEKETILETPDNKENIAEPEPAELNNILLKLLKSPNINSKKWIYEQYDHEVQLNTVVRPGKDASVLRLKEAHPKALALVADCNPTYCKLNPYGGSLNLVCESVRNLATVGAKPIGMLDNLNFGNPEKPERFYQIKKCIEGLADGAEIIGVPVVGGNVSLYNETVIDGKDYPINPTPVISIVGTIENINNIPKGAKEGDILIITAPTKDEMGGTEYYKQIHNTEEGIVPKANLEVEKEIYSKVCELVNNGLINEAVDCSKGGLGVAISKLCMTNNIGVELDLGDYNTNGLRNDILLFSESSGRIILSVDKNNADKVVKELNGAIIGTVKGNELKIKLNDNELINLPIEEMKNKYENAFSEMMGENI
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_ECO45
Sequence: MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRAVEGTPFECLKDAFVGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELIPASQIDRLATLPTYEEAIARLMATMKEASAGKLVRTLAAVRDAKEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: NADA_APLCA
Sequence: MSPVAIIACVCLAVTLTSISPSEAIVPTRELENVFLGRCKDYEITRYLDILPRVRSDCSALWKDFFKAFSFKNPCDLDLGSYKDFFTSAQQQLPKNKVMFWSGVYDEAHDYANTGRKYITLEDTLPGYMLNSLVWCGQRANPGFNEKVCPDFKTCPVQARESFWGMASSSYAHSAEGEVTYMVDGSNPKVPAYRPDSFFGKYELPNLTNKVTRVKVIVLHRLGEKIIEKCGAGSLLDLEKLVKAKHFAFDCVENPRAVLFLLCSDNPNARECRLAKRFYRIA
What is the function of this protein?
Synthesizes cyclic ADP-ribose (cADPR), a second messenger for calcium mobilization from endoplasmic reticulum; ADP-ribose is a minor product (PubMed:1650254, PubMed:10861229).  Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate from 2'-phospho-cADPR and nicotinic acid as well as from NADP(+) and nicotinic acid; with NADP(+) as substrate preferentially catalyzes NADP(+) hydrolysis rather than NAADP(+) synthesis, about 70-fold better at pH 7. 4 (PubMed:11829748, PubMed:16690024).  Has cADPR hydrolase activity at very high enzyme concentrations, which is probably not physiological (PubMed:10861229).  The conversion of NAD(+) into ADP-ribose is also only observed at high enzyme concentrations and results from the hydrolysis of cADP-ribose (PubMed:10861229).
What are the official names of this protein?
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase, ADPRC, ADRC, NAD glycohydrolase, NAD(+) nucleosidase, NADase.
What is the protein family that this protein belongs to?
Belongs to the ADP-ribosyl cyclase family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Note=Localized to vesicles or granules within ova of all stages.
Protein: RNH_BPT4
Sequence: MDLEMMLDEDYKEGICLIDFSQIALSTALVNFPDKEKINLSMVRHLILNSIKFNVKKAKTLGYTKIVLCIDNAKSGYWRRDFAYYYKKNRGKAREESTWDWEGYFESSHKVIDELKAYMPYIVMDIDKYEADDHIAVLVKKFSLEGHKILIISSDGDFTQLHKYPNVKQWSPMHKKWVKIKSGSAEIDCMTKILKGDKKDNVASVKVRSDFWFTRVEGERTPSMKTSIVEAIANDREQAKVLLTESEYNRYKENLVLIDFDYIPDNIASNIVNYYNSYKLPPRGKIYSYFVKAGLSKLTNSINEF
What is the function of this protein?
Plays essential roles in DNA replication by removing the RNA primers from lagging strand fragments.  Exhibits 5'to 3' exonuclease activity on either RNA/DNA or DNA/DNA duplexes and endonuclease activity on either flap or fork DNA structures.
What are the official names of this protein?
Ribonuclease H, RNase H.
Protein: INCA1_MOUSE
Sequence: MQGQEDGDSILPFAKCSRVVSRFSPCSLPPQNRRPMPQPYGDAFWENLSQRSSSNWMVEQYIPPILRATDCSRPSLHPLEGLPPPEKLWRRKRKKLHLERMQKGPGSIPARVRAVTYHLEDLRRRQGIINELKRAQWGSSDATPELPALEEGFELLSTTKYFDVEEERATYPQKETYSVTPRDQLLWTPWTPVGQQGTYASGQLSSLTYSTATARKNPVYDPQAMELESEE
What is the function of this protein?
Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor.  Inhibits cell growth and proliferation and may play a role in cell cycle control (PubMed:21540187).  Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (PubMed:21750715).
What are the official names of this protein?
Protein INCA1, Inhibitor of CDK interacting with cyclin A1.
What is the protein family that this protein belongs to?
Belongs to the INCA family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RL27_NITMU
Sequence: MAHKKAGGSSRNGRDSNSKRLGVKRFGGELIPAGSIIIRQRGTRVHPGENVGMGKDHTLFAKVDGRVNFTVKGLPQRKTVSIIPA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: TR2M2_AGRVI
Sequence: MSASSLLDKQCDHFSTKIVDLIMVDKADELDRRVAAAFSEREASRERRISQISGECNAGLACKRLADGRFPEISAGQRVAVLSAYIYVGEEILRWILEPEASVRTRVSGLVAIDLAPSCMDISRAQLLQTMNLLSGKRCAPSDLSHFVAISISETARSRTLQMAPYEEGSLKSVTGFTVIIEEAVPFDMVAYGRNLMLKASAGSFPTIDLLYDYRLFLDKCSDSGRIGFFPEDVPRPKVAVIGAGISGLVVASELLHAGVDDVTIYEAGDRVGGKLWSHAFKDAPGVVAEMGAMRFPPAASCLFFFLERYGLSSMRPFPNPGTVDTDLVYEGCRYMWKAGQQPPKLFHRVYSGWHAFLKDGFLEGDIVLASPDAITEALKSGDIRRAHDSWQIWLNRFGRESFSSAIERIFLGTHPPGGETWSFPHDWDLFKLMGIGSGGFGPVFESGFTEILRLVINGYEENQRMCSEGISELPRRIASQVVNGVSVSQRIRHVQVRAIEKEKTKIKIRLKSGISELYDKVVVTSGLANIQLRHCLTCDTTIFRAPVNQAVDNSHMTGSSKLFLLTERKFWFDHMLPSCVLMDGFAKAVYCLDYEPQDPNGKGLVLISYTWEDDSHKLLAVPDKKERLCLLRDAISKSFPVFAQHLVPACADYDQNVVQHDWLTDENAGGRFKLNRRGEDFYSEELFFQALDTTNDTGVYLAGCSCSFTGGWVEGAIQTACNAVCAIIHNCGGILAKDNPLKHPWKRYNYRNRN
What are the official names of this protein?
Tryptophan 2-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2-monooxygenase family.
Protein: GLMU_MYCBT
Sequence: MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHEVMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNNRVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGTSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASEMACQQPTQPPDADQTP
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_SHEON
Sequence: MMRILVSNDDGVNAPGIKALTEALAEIATVMTVAPDRNCSGASNSLTLTNPLRINRLDNGYISVHGTPTDCVHLAIRELCDGEPDMVVSGINAGANMGDDTLYSGTVAAAMEGRFLGFPAVAISLNGKAFKHYHTAAVYARRIVQGLLAHPIASDQILNINVPDLPLDEIKGISVTRLGARHKAEGIVRTQDPAGREIFWLGPPGLEQDASEGTDFHAIAHGYVSITPLTVDLTAYRQLSILQNWVDKI
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRSM1_MOUSE
Sequence: MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLVTIKVLDLHENQLTALPDDMGQLTVLQVLNVERNQLTHLPRSIGNLLQLQTLNVKDNKLKELPDTLGELRSLRTLDISENEIQRLPQMLAHVRTLETLSLNALAMVYPPPEVCGAGTAAVQQFLCKESGLDYYPPSQYLLPVLEQDGAENTQDSPDGPASRFSREEAEWQNRFSDYEKRKEQKMLEKLEFERRLDLGQREHAELLQQSHSHKDEILQTVKQEQTRLEQDLSERQRCLDAERQQLQEQLKQTEQSIASRIQRLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETENLRQREIAAAMQQMLTESCKSRLIQMAYESQRQSLAQQACSSMAEMDKRFQQILSWQQMDQNKAISQILQESVMQKAAFEALQVKKDLMHRQIRNQIRLIETELLQLTQLELKRKSLDTETLQEMVSEQRWALSNLLQQLLKEKKQREEELHGILAELEAKSETKQENYWLIQYQRLLNQKPLSLKLQEEGMERRLVALLVELSAEHYLPLFAHHRISLDMLSRMSPGDLAKVGVSEAGLQHEILRRAQDLLAVPRVQPELKPLENEVLGALEPPTAPRELQESVRPSAPPAELDMPTSECVVCLEREAQMVFLTCGHVCCCQQCCQPLRTCPLCRQEISQRLRIYHSS
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos (By similarity).  Bacterial recognition protein that defends the cytoplasm from invasive pathogens (By similarity).  Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase LRSAM1, Leucine-rich repeat and sterile alpha motif-containing protein 1, RING-type E3 ubiquitin transferase LRSAM1, Tsg101-associated ligase.
What are the subcellular locations of this protein?
Cytoplasm. Note=Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (By similarity).