PharMolix/UniProtQA huggingface dataset:
Protein: NXT2_RAT
Sequence: MAMAVDFKMYVDQACRAAEEFVNIYYETMDKRRHALVRLYLDKATLIWNGNVVTGLEALANFFEMLPSSEFQINMLDCQPVHEQATQYQTTVLVVTSGVVKFDGNKQHFFNQNFLLTAQSTPNSTVWKIASDCFRFQDWASI
What is the function of this protein?
Regulator of protein export for NES-containing proteins.  Also plays a role in mRNA nuclear export (By similarity).
What are the official names of this protein?
NTF2-related export protein 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: PAND_LISIN
Sequence: MFRTMMNGKIHRATVTEANLNYVGSITIDSAILEAVDMLPNEKVQIVNNNNGARIETYIIPGEPGSGVICLNGAAARHVQVGDVVIIMSYGMFTSEEAKTHEPKIVVLDEKNHIEMILPEEKAHTTL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXA_SACD2
Sequence: MTFIHPTAIVDPAAKLADDVKVGPWTYIGEGVEIGAGSVIESHVVLKGPTQIGCNNHIYQFSSVGEATPDLKYKGEPTKLIIGDNNIIREGVTLHRGTVQDRGETRIGNNNLLMAYVHVGHDSVVGNHCILVNNAALAGHVIVDDYAILGGFTLVHQFSRIGAYSFTGMGSAVGKDIPAFMMVAGAPAAARSINMEGLKRRGFSKDDIAKLNKSFKLIYRRGLTLEAAIEELTPLAQDCAAIVTLIASLRASKRGIVR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y761_METJA
Sequence: MIDAHTHLDVRSFEDLEKMALSGIETIITCAHDPYKMSTPEVYLDHWDRLINLEVKRGEMAGVEVKVAVGVHPMGYPKNWEVLIKKLPEFLDNENVVAIGETGLHYLTEDEKNLLREQLYLAKDYNMPIIIHTPEKNKKEALIEILKILDEVKIKDSLVMIDHINKETVDLIDRDVYVGLTVQPSMKLTHEEAAEIIKNYNKKFILSSDLGSLKADIYALPRTKLYMKNIGVDEEKIIASVYKNAKGFYRL
What are the official names of this protein?
Uncharacterized metal-dependent hydrolase MJ0761.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
Protein: KAD_HELPS
Sequence: MKQLFLIIGAPGSGKTTDAELIAKNNSEKIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSDKGIILIDGYPRSVEQMQALDKELSAQNEVVLKSVIEVEVSENTAKERVLGRSRGADDNEMVFHNRMRVFLDPLGEIQNFYKNKKVYKAINGERSIEEIVHEMQEYILSFGN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBL75_ARATH
Sequence: MDLSGSRDVISSLPDDISSHILSFLPTKEAASTSVLSKKWRYLFAFVPNLDLDDSVYLNPENETEISTSFMDFVDRVLALQGNSPLHKFSLKIGDGIDPVRIIPWINNVLERGVSDLDLHLNLESEFLLPSQVYLCKTLVWLKLRFGLYPTIDVEDVHLPKLKTLYIEATHFEEHGVGLTKLLSGCPMLEDLVLDDISWFIWDFASVSVPTLKRLRFSWQERDEFPKSVLLDTPNLVYLKFTDTVAGKYPKVNLDSLVEAHIDLRLLKPLLINYHQGYGENDMVGNATDFIMRICNVKTLYLSANTLQVLTYSCDAIPIFNNLTHLTIESNPRVGWQSVPGLLKNSPNLETLIFQGLIHKATYRCGDVCLCKKPRKEILSC
What are the official names of this protein?
F-box/LRR-repeat protein At4g14103.
Protein: PSAM_PROM9
Sequence: MEPTQTINLIALSLIVVVHAGVLALRLGISLGRN
What are the official names of this protein?
Photosystem I reaction center subunit XII, PSI-M.
What is the protein family that this protein belongs to?
Belongs to the PsaM family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RL40_TRYCR
Sequence: MQIFVKTLTGKTIALEVESSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGVMEPTLEALAKKYNWEKKVCRRCYARLPVRASNCRKKACGHCSNLRMKKKLR
What is the function of this protein?
Component of the 60S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-60S ribosomal protein L40.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [60S ribosomal protein L40]: Cytoplasm.
Protein: EFP_LEGPC
Sequence: MAVYSTNEFKNGLKVMVDDAPCSILDCEFVKPGKGQAFTRIKIRNLKTGRVVERTFKSGDTLPSADVADVEMQYLYNDGEYWHFMVPDTFEQYAVTENVLADAAQWLKEQDVCVLTLWNNEPIQVTPPNFVILAITETDPGLKGDTSGGGGKPATLETGAVVRVPLFVQTGELIKVDTRKGEYVSRAKE
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_STRPD
Sequence: MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAEDYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGMDKTDKDEKILVFDLGGGTFDVSILELGDGVFDVLATAGDNKLGGDDFDQKIIDFLVAEFKKENGIDLSQDKMALQRLKDAAEKAKKDLSGVTQTQISLPFITAGSAGPLHLEMSLSRAKFDDLTRDLVERTKTPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQHIVIKSNDGLSEEEIDRMMKDAEANAEADAKRKEEVDLKNEVDQAIFATEKTIKETEGKGFDTERDAAQSALDELKAAQESGNLDDMKAKLEALNEKAQALAVKMYEQAAAAQQAAQGAEGAQANDSANNDDVVDGEFTEK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RL28A_STRCO
Sequence: MAANCDVCGKGPGFGNNISHSHRRTSRRWNPNIQRVRTVVSGTPKRVNACTSCIKAGKVSR
What are the official names of this protein?
50S ribosomal protein L28-1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: NU3C_MARPO
Sequence: MFLLQKYDYFFVFLLIISFFSILIFSLSKWIAPINKGPEKFTSYESGIEPMGEACIQFQIRYYMFALVFVIFDVETVFLYPWAMSFYNFGISSFIEALIFILILIIGLVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: KTHY_FRATO
Sequence: MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDEEIHSDSELLMIYAGRVQHYRNLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRALNNNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAGLEFFNRTRKVFKDLVKDLDNAIEIDAAKSIQEVEKQIYLILDKHFNFQN
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: FAEB_ASPNG
Sequence: MKVASLLSLALPGAALAATDPFQSRCNEFQNKIDIANVTVRSVAYVAAGQNISQAEVASVCKASVQASVDLCRVTMNISTSDRSHLWAEAWLPRNYTGRFVSTGNGGLAGCVQETDLNFAANFGFATVGTNGGHDGDTAKYFLNNSEVLADFAYRSVHEGTVVGKQLTQLFYDEGYNYSYYLGCSTGGRQGYQQVQRFPDDYDGVIAGSAAMNFINLISWGAFLWKATGLADDPDFISANLWSVIHQEIVRQCDLVDGALDGIIEDPDFCAPVIERLICDGTTNGTSCITGAQAAKVNRALSDFYGPDGTVYYPRLNYGGEADSASLYFTGSMYSRTEEWYKYVVYNDTNWNSSQWTLESAKLALEQNPFNIQAFDPNITAFRDRGGKLLSYHGTQDPIISSTDSKLYYRRVANALNAAPSELDEFYRFFQISGMGHCGDGTGASYIGQGYGTYTSKAPQVNLLRTMVDWVENGKAPEYMPGNKLNANGSIEYMRKHCRYPKHNIHTGPGNYTDPNSWTCV
What is the function of this protein?
Involved in degradation of plant cell walls.  Hydrolyzes of the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.
What are the official names of this protein?
Feruloyl esterase B, Cinnamoyl esterase, CinnAE, FAE-I, Ferulic acid esterase B, FAEB.
What is the protein family that this protein belongs to?
Belongs to the tannase family.
What are the subcellular locations of this protein?
Secreted.
Protein: ADDB_STRT1
Sequence: MKLLYTDMSQDLTEILTEQASSYAQKGKRVFYIAPSALSFEKERKVLEYLPQSASFDITVTRFTQMARYFILNTSNPKTQLDDTGLAMIFYKVLLHMGDDELKVYGRLRKDSNFINQLVDLYKELQQANMTVLDLQHLDQVEKQEDLVRIFSAAQDLLLAGDFDNQSKLSAFFKEITSGHLDEALSNTVLVIDGFTRFSAEEEALVALLNDKCHQIVVGTYTSQKAYKANFVYGNAYQASVDFLRTLAQTYKVIPDYVTTDKEGNLSFARISRLLESRHDFSTVDETVTEQDKHALKVWEVVNQKEEVAQVAKSIRQLLADGKRYKDILVLLGDEESYKLHVGQIFRKFDIPYYFGKEESMSSHPLVEFVDSLERIKRYNYRAEDLLNLVKSGLYGGFAQEDLDLFEYYVNFADIKGRHKFLSDFTANSRDKYNLDQINALRSQLIEPLDKFLNSRKQKGSSLLKKLVVFLEAVQLPSQMFELSTKASEAEKEQNEQVWKAFTHILEQVETIFGDESLSVDDFLSILRSGMLACDYRTVPATVDVVNVKKYDLIQPHSAPYVFALGMTQSHFPKVGQNKSLLSDEERSRINEATDEHRRLDIVTQINSKRGHFVAMSLFNAASEQLVLSQPQIINESQDDMSVYLKELLDLGIPLVEKGRNRFEAKGDQIGNYRDLLSTVIALNSSHLDLDLDKETQTFWSVAVRYLRKRLDKDQVLIPKVIDDVTTTKVDDQVMQLVFPEEEPLKLSATALTTFYNNQYLYFLRYVLELEELESIHPDARHHGTYLHRVFERVMGDSSSESFDDKLEKAIAQTNQDQPFEILYTEDQESRFSRQILEDIARSTASVLRDNAAVKVECEEVKFDLLLANSIKITGIIDRVDRLTDGALGVVDYKTGKNVFDIQKFYNGLSPQLVTYLEALRQTYKVDADQLFGAMYLHMQVPQLNLSQIGLEKLAAQAHKELTYKGLFVASETEHLTGGNYDLQKTVTYDKEDLETLLDYNIKLFRSAAEVIRSGNFAINPYTEDGKSVQGDQIKSITHFEADRHMGQARKLLRLPKKGKKEAYLELMAKTEEENQMQVSENTISFPVIDHAVRVDKKDQEDNHVD
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: NOS2_CAPHI
Sequence: VEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAQEMFEHICRHVRYATNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDG
What is the function of this protein?
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.  In macrophages, NO mediates tumoricidal and bactericidal actions.  Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2.  As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM.  Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8.
What are the official names of this protein?
Nitric oxide synthase, inducible, Inducible NO synthase, Inducible NOS, iNOS, NOS type II, Peptidyl-cysteine S-nitrosylase NOS2.
What is the protein family that this protein belongs to?
Belongs to the NOS family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization.
Protein: PHNW_SALTI
Sequence: MTSRNYLLLTPGPLTTSRTVKEAMLFDSCTWDDDYNIGVVEQIRQQLTALATASEGYTSVLLQGSGSYAVEAVLGSALGPQDKVLIVSNGAYGARMVEMAGLMGIAHHAYDCGEVARPNVQAIDAILNADPTISHIAMVHSETTTGMLNPIDEVGALAHRYGKTYIVDAMSSFGGIPMDIAALHIDYLISSANKCIQGVPGFAFVIAREQKLAACKGRSRSLSLDLYAQWRCMEDNHGKWRFTSPTHTVLAFAQALKELAKEGGVAARHQRYQQNQRSLVAGMRALGFNTLLDDELHSPIITAFYSPEDPQYRFSEFYRRLKEQGFVIYPGKVSQSDCFRIGNIGEVYAADITALLTAIRTAMYWTK
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase, 2-aminoethylphosphonate aminotransferase, AEP transaminase, AEPT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: RL16_RHILW
Sequence: MLQPKRTKYRKQFKGRIKGVAKGGSDLAFGEFGLKAQEPNRVNAREIEAARRAITRYMKRAGRVWIRVFPDVPVTKKPTEVRMGKGKGSVEYWACKVKPGRMMFEIDGVSEEIAREALRLGSAKLSVKTRFVQRIAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: A305_VACCW
Sequence: MSAVDFLERLIKAGVYIYVLRTKCVIAALLVKNYSIKDE
What are the official names of this protein?
Uncharacterized protein A30.5.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus A30.5 protein family.
Protein: AHDC1_HUMAN
Sequence: MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPPASPPDKAFSTHAFSENPRPPPRRDPSTRRPPVLAKGDDPLPPRAARPVSQARCPTPVGDGSSSRRCWDNGRVNLRPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPGDLQYSFFSSPSLANSIRSPEERATPHAKSERPSHPLYEPEPEPRDSPQPGQGHSPGATAAATGLPPEPEPDSTDYSELADADILSELASLTCPEAQLLEAQALEPPSPEPEPQLLDPQPRFLDPQALEPLGEALELPPLQPLADPLGLPGLALQALDTLPDSLESQLLDPQALDPLPKLLDVPGRRLEPQQPLGHCPLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKILCRRRKAGRGRKADAGPEGRLLPLPMPTGLVAALAEPPPPPPPPPPALPGPGPVSVPELKPESSQTPVVSTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLRVSAEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPAVVAAEAATVAAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQCAGRCSPPRCWTPSEPESVHQAPDTQSISHFLHRVQGFRRRGGKAGGFGGRGGGHAAKSARCSFSDFFEGIGKKKKVVAVAAAGVGGPGLTELGHPRKRGRGEVDAVTGKPKRKRRSRKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFASTGLESGASGRGSYYSTGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASRPESRKASGTYAGPPTSALPAQRGLATFPSRGAKASPVAVGSSGAGADPSFQPVLSARQTFPPGRAASYGLTPAASDCRAAETFPKLVPPPSAMARSPTTHPPANTYLPQYGGYGAGQSVFAPTKPFTGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKASFFSSSEGAPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASATSAASAASSSSSSFQPSPENCRQFAGASQWPFRQGYGGLDWASEAFSQLYNPSFDCHVSEPNVILDISNYTPQKVKQQTAVSETFSESSSDSTQFNQPVGGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFPTSASAAASGYPSKRSTGPRQPRGGRGGGACSAKKERGGAAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQSRAFGVGERDPCDFIGPYSMNPSTPSDGTFGQGFHCDSPSLGAPELDGKHFPPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPTKLAACEPLKHGLQGASLGHAAAAQAHLSCRDLPLGQPHYDSPSCKGTAYWYPPGSAARSPPYEGKVGTGLLADFLGRTEAACLSAPHLASPPATPKADKEPLEMARPPGPPRGPAAAAAGYGCPLLSDLTLSPVPRDSLLPLQDTAYRYPGFMPQAHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL
What is the function of this protein?
Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237).  Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237).  Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237).
What are the official names of this protein?
Transcription factor Gibbin, AT-hook DNA-binding motif-containing protein 1.
Protein: NITO_DROME
Sequence: MSSHRDGAGADRITIKIHNMKRSASRSPGPASRSSLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRRRLDRSPSRYGSPHREPYMRGPPPAERPAGYKVLCVSALPPKAPDDFIEETLYREYKKFGDFSVRLAHDLDERVAYVCFRTPEDAREAKHHKPRLIIYDKMAIVEPVYKSTTRPEYRPRGHSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPHPPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFKSSKPPYDESALEYRRPEYDPYYEESAAYAPRGGYSPYPPRGGYRGRGGYRGRGRGMYHYHNDVHRPPHPGSLAGSSSSVPPPGGVEDEWRRPPGESYDRGARSSSREPGVERSRSRSPLKRARSPGSDSDTSTRRNDALASASTVPDVARKCSTVWTGALILKSSLFPAKFHLTDGDTDIVESLMRDEEGKHNLRITQRLRLDPPKLDDVQKRIASSSSHAIFMGLAGSTNDTNCDDASVQTRPLRNLVSYLKQKEAAGVISLLNKETEATGVLYAFPPCDFSTELLKRTCHSLTEEGLKEDHLVIVVVRGGTA
What is the function of this protein?
RNA-binding protein that acts as an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs (PubMed:27919077, PubMed:29535189, PubMed:29555755).  M6a modification plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:29535189, PubMed:29555755).  In the WMM complex, may act by binding target RNAs and recruiting the WMM complex (PubMed:29535189).  Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:26324914, PubMed:29535189, PubMed:29555755).  M6A methylation is also required for neuronal functions (PubMed:27919077).  Acts as a positive regulator of canonical Wg signaling during wing disk and eye development (PubMed:16547102, PubMed:18174108).
What are the official names of this protein?
RNA-binding protein spenito.
What is the protein family that this protein belongs to?
Belongs to the RRM Spen family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RF1_SACD2
Sequence: MKASILEKLEHLAERFTEVGALMGDPDVISNQDKFRDLGREYAELEPVIKCYNEYNTVLGNIAEAKVLISDSDPDMRAMGQDELKENEAALEPLELELQKLLLPKDPNDGKNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAESKGWKVEIISENQGEHGGYKEIITRVVGQGVYSELKFESGAHRVQRVPETESQGRIHTSACTVAVMPEADEMAEVNINKADLRIDTFRASGAGGQHVNKTDSAIRLTHIPTGVVVECQDERSQHKNRAKAMSLLASRLSMAQEEKAAAEQASARKSLVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMQGALGDVIQPLVNEYQADQLAALSE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLYP_YERPS
Sequence: MKKRALLLSMSVLAMLYIPAGQAAEIDRLTVVKQYVDNVLNKASDTYHGDKPSPLLADGVDPRTGQQMEWIFPDGRRAVLSNFSAQQNLMRVMSGLSELSGDPQYQKRAEDIVRYHFQNYQDNSGLLYWGGHRFVDLKTLQPEGPSEKEKVHELKNAYPYYDLMFSVDSDATTRFIRGFWNAHVYDWRILETSRHGEYGKPMGALWESTFEQQPPFFATKGLSFLNAGNDLIYSASLLYKYQQDQGALVWAKRLADQYVLPRDAKTGLGVYQFTQALKREEPTDDADTHSKFGDRAQRQFGPEFGPTALEGNMMLKGRTSTLYSENALMQLQLGKDLGGQGDDLLKWTVDGLKAFAKYGYNEQDNTFRPMIANGQDLSNYTLPRDGYYGKKGSVLKPYKAGNEFLISYARAYAVDNDPLLWKVARGIASDQGLGDIGSAPGKEMKVKLDTTNSDPYALFALLDLYNASQVAEYRSLAEKVADNIIKTRYIDGFFMASPDRQYADVDAIEPYALLALEASLRNKPQAVAPFLNGAGFTEGAYLMADGSARISTRDNELFLLNVGETLQPNGRK
What are the official names of this protein?
Periplasmic pectate lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 2 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SYP_SULIA
Sequence: MQITREKWSKNFSEWFDWVLREGEFYDYGRYPVKGMGVWMPYGFKLRQNIISIIRNLLDSTGHEEVLFPLLIPEDLLSRESTHIKGFEEEVFWVTKGGSEDLDVKLALRPTSEVAITTMENLWLKSYKQLPKKYYQIVSVFRYETKATRPMIRLREITTFKEAHTVHETYDDAQRQVEEAIEIYKKIFNNLAIPYVLSERPEWDRFAGALHTYAFDTIMPDGKVMQIGTVHHLGQNFSRALDFKIQKKDGSLDYPHQTSYGISDRAIASVIAIHGDDHGPILPPSVAPIKVVVVPIPAKNEEGTQQVMKYSVEICEMLNKNNITCVTDQDTEKTPGEKFYIWEIKGVPIRLEIGPRELASSTVFIKRRDNLKSYTVKKEEVVNKVKEVLNEIQEDLRKRAWESLKSRIEYANDIEKAKNLLENNSGIVEVPWCGSKECGLKIEELTNARVLGYPIEDRKVNDKCVICKMNAKTVLRVAKTY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNX16_HUMAN
Sequence: MATPYVPVPMPIGNSASSFTTNRNQRSSSFGSVSTSSNSSKGQLEDSNMGNFKQTSVPDQMDNTSSVCSSPLIRTKFTGTASSIEYSTRPRDTEEQNPETVNWEDRPSTPTILGYEVMEERAKFTVYKILVKKTPEESWVVFRRYTDFSRLNDKLKEMFPGFRLALPPKRWFKDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPGPFDSLEESRAFCETLEETNYRLQKELLEKQKEMESLKKLLSEKQLHIDTLENRIRTLSLEPEESLDVSETEGEQILKVESSALEVDQDVLDEESRADNKPCLSFSEPENAVSEIEVAEVAYDAEED
What is the function of this protein?
May be involved in several stages of intracellular trafficking.  Plays a role in protein transport from early to late endosomes.  Plays a role in protein transport to the lysosome.  Promotes degradation of EGFR after EGF signaling.  Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.
What are the official names of this protein?
Sorting nexin-16.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Lysosome.
Protein: RL4_LIMRD
Sequence: MTSVNLYKQDGSQNGTVELNDAVFGVEPNENVVFDAILRQRASLRQGTHAVKNRSAVSGGGKKPWRQKGTGRARQGSIRSPQFRGGGIVFGPTPRSYKYSLPRKVRQLAIKSALSQKVLDNSFVVVDALNFDAPKTKEFADVMGNLNVAEKTLVVVTDDDKNAALSARNLANATVVTPAGVNILNVVDNQKIVITKSALSQVEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ACEK2_PSET1
Sequence: MQPRHIAELILTGFKKHYLLFQKTTAKAPLAFAKRDWQAINDISRLRISHYDDRVNETTATLRQQQTEQLDEQLWLEVKKLYQHFLCFHPQAELAETFYNSVFCRLYHRRYFHNDFIFVEATLKDAPAVPVEAEYRSYFPVVDGLKPTIKQIINHFDFKAPFVNLERDIRLLVKAFYKQAPDTHHKAWQMRFDILHTPFYRNKAAYIVGRVVSQSGVQPFIIAVLHHEDKGLYLDALLTKSSQMRVIFGFARAYFMVETHAPCALVRFLNQLMPNKTIAELYNAIGFHKQGKTEFYREFLNHLTHSNDEFTIAPGTPGMVMMVFTLPSFGYVFKVIKDKFGESKPFGRDTVLKRYQLVKKHDRVGRMADTIEYSNVVFPLARFDSNLLQQLHQTIGSSMVIEGDWLIIKHLYIERRMTPLNLFLENADDASAADAIEEYGQALKEMIAVNIFPGDMLLKNFGVSKHKRIIFYDYDEVQYLTDMNFRALPKAKTYDDYLMDEQSYSVAPQDVFPEQLCTFVMPNPIYKQFLMSTHPELIDVNFWKQAQQNIKNGQVSHIYPYPTAQRFIHHW
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase 2, IDH kinase/phosphatase 2, IDHK/P 2.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAHX_ARATH
Sequence: MGITGSLTPDQLDFFHSQGYLVIESFASEDEIRGLRKRMDELLNQFDCSVSSIFSTKNQKHTTDNYFFESAEKISFFFEEKAFGDDGKLKQPKQLSINKVGHALHELDPLYKDFTYSSKFSSLASSLGYRRPVVMQSMYIFKQPGIGGEVVPHQDNSFVYTDPQSCTGLWIALEDSTLVNGCLWAIPGSHKNGLVRRFIRGDNGITFDQPSPSYEQKDFVSIEMKAGSLIAIHGDLIHQSFENLSSKSRHAYSLHVVESDGCKWAKDNWIQRAKMPEPLYVLP
What is the function of this protein?
Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
What are the official names of this protein?
Phytanoyl-CoA dioxygenase, Phytanoyl-CoA 2-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.