PharMolix/UniProtQA huggingface dataset:
Protein: P5CR3_BOVIN
Sequence: MAAAAEESGWRRVGFVGAGRMAEAIAQGLIQAGKVEAEHVLASAPSDRNLCRFRAMGCQTTHSNLEVLHSCSLVFFATKPHILPAVLVEVAPAVTAEHILVSVAAGVSLSTLEKLLPPMARVLRVSPNLPCIVQEGAMVMARGCCAGSYEAQLLRSLLEACGQCEEVPEAQVDVHTGLSGSGVAFVCAFSEALAEGAIKMGMPSGLAHRIAAQTLLGTAKVLLQKGQHPAQLRTDVCTPGGTTIYGLHVLEQGGLRATAMSAVEAATCRARELSRNPSPVVAQVPSVLQALQGEGALAHREHSSVARS
What is the function of this protein?
Enzyme that catalyzes the last step in proline biosynthesis.  Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs).  PYCRL is exclusively linked to the conversion of ornithine to proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase 3, P5C reductase 3, P5CR 3, Pyrroline-5-carboxylate reductase-like protein.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_TREDE
Sequence: MDYEKNVTLKEKSHAELSVKIKKSDVQESYKKLLNKYSKELQIPGFRKGKVPVSVLETKYGDAIKGDLAGDLIEESLKEIFESLDEYERPLPYSYPELNEKPELKVEEDFSFTVHYDVFPKVEIKKTEGFTIEVPEASVSEKDIKKELERLQERNALVTACKEGTSAEKDHIATIDYCELDDEGKTISGTERKDFVFTIGSGLNIYKIDDDIVGMKKGESKEITKTFPEDDSNKDLAGKTKKIKVTLTALKYKDLPALDDDFAQDINEKYKNLDELKADIKKKFEISVEEKIKSLQKNALTEQMVKEHTIDLPESMVRAELESRWMMMANQFRTTPEELEKMFGKGPQSKAALLEGWREDSEKTLKERVLIETLLKEKNIEVSDDEIEAEYVRLSERMDIALDELKKYYSNPREKEYLSEGLKEEKLFKALYEKSTIKKGKKLTFDELLKD
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PSBN_CHLSC
Sequence: METATLVAISISGSLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: EMBP1_WHEAT
Sequence: MASSSSATSGDDRPPAAGGGTPAQAHAEWAASMHAYYAAAASAAGHPYAAWPLPPQAQQHGLVAAGAGAAYGAGAVPHVPPPPAGTRHAHASMAAGVPYMAGESASAAGKGKRVGKTQRVPSGEINSSSGSGDAGSQGSSEKGDAGANQKGSSSSAKRRKSGAAKTEGEPSQAATVQNAVTEPPLEDKERSASKLLVLAPGRAALTSAAPNLNIGMDPLSASPSSLVQGEVNAAASSQSNASLSQMDERELKRERRKQSNRESARRSRLRKQQECEELAQKVSELTAANGTLRSELDQLKKDCKTMETENKKLMGKILSHDDKMQQSEGPSVVTTLSIQVEAPEPHQGGHGKAS
What is the function of this protein?
Interacts specifically with the 8-bp sequence 5'-CACGTGGC-3'in the abscisic acid response element (ABARE).  Also binds to the hexamer motif 5'-ACGTCA-3' of histone gene promoters.
What are the official names of this protein?
DNA-binding protein EMBP-1, Histone promoter-binding protein 1a(1), HBP-1a(1).
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HBB2_GOBGI
Sequence: VEWTDFERATINDIFSKLEYEVVGPATLARCLVVYPWTQRYFGNFGNLYNAAAIAENPMVSKHGITILHGLDRAVKNMDDIKNTYAELSVLHSEKLHVDPDNFQLLADCLTIVVAARFGNTFTGEVQAAFQKFLSVVVSSLGRQYH
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-2, Beta-2-globin, Hemoglobin beta-2 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: NEUA_PONAB
Sequence: MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENVAKQFGAQVHRRSSEVSKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVSVSDKLAVVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSGAPADACSTAQKAVGYICKCNGGRGAIREFAEHIFLLMEKVNNSCQK
What is the function of this protein?
Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid.  Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity).
What are the official names of this protein?
N-acylneuraminate cytidylyltransferase, CMP-N-acetylneuraminic acid synthase, CMP-NeuNAc synthase.
What is the protein family that this protein belongs to?
Belongs to the CMP-NeuNAc synthase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIAA_MYCTU
Sequence: MRPLAIIGPTGAGKSQLALDVAARLGARVSVEIVNADAMQLYRGMDIGTAKLPVSERRGIPHHQLDVLDVTETATVARYQRAAAADIEAIAARGAVPVVVGGSMLYVQSLLDDWSFPATDPSVRARWERRLAEVGVDRLHAELARRDPAAAAAILPTDARRTVRALEVVELTGQPFAASAPRIGAPRWDTVIVGLDCQTTILDERLARRTDLMFDQGLVEEVRTLLRNGLREGVTASRALGYAQVIAALDAGAGADMMRAAREQTYLGTRRYVRRQRSWFRRDHRVHWLDAGVASSPDRARLVDDAVRLWRHVT
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: GSTUK_ARATH
Sequence: MANLPILLDYWPSMFGMRARVALREKGVEFEYREEDFSNKSPLLLQSNPIHKKIPVLVHNGKPVCESLNVVQYVDEAWPEKNPFFPSDPYGRAQARFWADFVDKKFTDAQFKVWGKKGEEQEAGKKEFIEAVKILESELGDKPYFGGDSFGYVDISLITFSSWFQAYEKFGNFSIESESPKLIAWAKRCMEKESVSKSLPDSEKIVAYAAEYRKNNL
What is the function of this protein?
Exhibits glutathione-dependent thiol transferase activities.  Can use glutathione (GSH) and 1-chloro-2,4-dinitrobenzene (CDNB) as substrates.  Involved in the regulation of far-red light influence on development (PubMed:17220357).  Regulator of the interplay between light and JA signaling by increasing JAR1/FIN219 efficiency (PubMed:28223489).  Maybe involved in gravitropic signal transduction (Probable).
What are the official names of this protein?
Glutathione S-transferase U20, AtGSTU20, FIN219-interacting protein 1, GST class-tau member 20.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Tau family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: TCB1_MOUSE
Sequence: EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSASYQQGVLSATILYEILLGKATLYAVLVSTLVVMAMVKRKNS
What are the official names of this protein?
T-cell receptor beta-1 chain C region.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HUTI_HALH5
Sequence: MVQHFDTLLVNIGQLLPMESKGPKRGKEMSELQLLEHAALGIRDGKVAFIGTMVEADTFTANQMIDCQGKLVTPGLVDPHTHLIFGGSREHEMALKQQGVPYLEILKNGGGILATVEATRAASEEELITKAICHLNRMLSYGVTTIEAKSGYGLDRETEWKQLRAAKAVGEQHPIDIVSTFLGAHAIPTSHRNDPDRFLDEMADMLGEIKEQNLAEFVDIFTETGVFTVEQSRTFLQKAKERGFGLKLHADEIDPLGGAELAGELGAISADHLVGASDQGIQKMAAAGTIACLLPGTTFYLGKDTYARARDMIDQGLAVTISTDFNPGSSPTENLQLIMSIAALRLKMTPEEIWHAVTVNGAHAIGRGDTAGQLAVGRAADVVVWDAKNYYYVPYHYGVNHVHSVWKKGEVVYERRRAFEGLSISR
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
Protein: RLMF_PSEA6
Sequence: MTITTTVKAKTLAVNNKNAPHTSATMHPRNVHRNGYPMSALCQSYPTLEAHVIKAKSGQQSIDFSKAASVKALNAALLIHYYGLNMWDIPEGYLCPPVPGRADYIHGLADLLAKDNKGVVPTGNRVIGLDIGVGANAIYPIIGSQTYGWDFVGSDIDDVALKSATTLANNNPKLKPLLAVRKQHDKAYIFAGIIQPDDHFTFSLCNPPFHKSAEEAAMGSLRKVKGLGRNKQKSNNTGNAQPITANKLNFAGQSNELWCDGGELAFIQRMIKESVEYQSQVGWFTCLVSKSLHLKAIETSARYFGAKQFMKVDMGQGQKISRFVAWKFRD
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_HELAH
Sequence: MKFLALFFLALVGVAFAYDGGMDGMDMIKSYSILGAMIGLGIAAFGGAIGMGNAAAATITGTARNPGVGGKLLTTMFVAMAMIEAQVIYTLVFAIIAIYSNPFLS
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MRAY_VIBVY
Sequence: MIIWLAELLQPYFSFFRLFEYLSFRAILSVLTALGLSLWMGPRLIKRLQLLQIGQVVRNEGPESHFSKRGTPTMGGVMILAAISITILLWANLSNPYVWAVLAVLMGYGAVGFVDDYRKVVRKNTDGLIARWKYFWQSAIALVVAFALYAYGKDTAATQLVVPFFKDVMPQLGLMYIVLTYFVIVGTSNAVNLTDGLDGLAIMPTVLVAAGFAVIAWATGNVNFSQYLHIPYLPHASELVVVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGTIAVLVRQELVLVIMGGVFVMETLSVILQVGSYKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISMVLVLIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF2_YERPB
Sequence: MTDVTVKSLAAEIQTPVDRLVQQFADAGIKKSDVDSVTQQEKEILLAHLNREHGSVPNKLTLQRKTRSTLNIPSTGGKSKSVQIEVRKKRTYVNTPEAEQAKAEEQAQREAEEQAQREAEATAQKIAEEKAKREAEEQAKREAAEKAKRQAAEKEKVTNQQTDEKTKPAQTDKARREAEAAELKRSVEEETRRKVEEDAKRVAEEARKMAAENEGKWPEPVAEQTESADYHVTTSQHARAAEDENDAKVEGDRRSRTRGGKATKQKKGNKLSESKADREEARAVGRKGKRKPSTLQQSFNKPVVAVNRDVVIGETVTVAELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEALMSDRDIGVEAAAEHRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAANVPVVVAVNKIDKPEADPDRVKTELSQYGIQPEEWGGESQFINVSAKAGIGIDELLNAILLQAEVLELKAVRTGMANGVVIESFLDKGRGPVATVLVQQGTLNKGDIVLCGFEYGRVRAMRDELGRDITSAGPSIPVEILGLSSVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVSELNIVIKSDVQGSCEAICDSLEKLSTDEVKVRIVGSGVGGITETDATLAAASGAIILGFNVRADASARRVVETEGLDLRYYSVIYSLIDEVKQAMSGMLAPEYKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVIKRNNPIRVLRDNVVIYEGELESLRRFKDDVSEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIKRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTA_PECCP
Sequence: MNAKRIRGLLIFAAVIAIAVLIWRHFTQTSPAAPGTSEQHAARTSHSGNNSSGNGGGRRAAMRTLAPVQAAVTQSASVPYYLSGLGTVTSANTVTLRSRVNGQLMALHFQEGQQVKAGDLLAEIDPRPFQVELTQAQGQLAKDRAVLANAQQDLARYQQLVKTNLISRQELDAQTAAVRQAEGTLKADEGAVASAQLQLDYSKITAPISGRIGLKQVDVGNYITSGDTNGIVVITQTYPIDVVFTVPEAEISTILNAQKSGQPPMVEAWDRANQKKLSQGTLLSMDNQIDATTGTIKLKARFDNLDDALFPNQFVNIRMKVDTLKNAVVAPSAAVQMGNEGRFVWILNDKNEVSKRQVTTSIQYGQLVVVTAGLDADVKVVTDGIDRLTEGAKVEVVPSALTEKTPAIAGEKS
What are the official names of this protein?
Multidrug resistance protein MdtA, Multidrug transporter MdtA.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LEUD_MYCS2
Sequence: MTGRVWVFGDSLNTDAMYPPDAMKLDVAAAAKMVFYQVRPGWTDEVQRGDIVVAGNNFGLGSSRPVAALFNELGVAALVAEEFNSLFFRNAVNAGLPAMTVPGVTEAFSDGDIGTFDLGTGEWHNDTTGAGGTVPVLPDLILDILAGGGVLPRLAERGYLPAELAETLRSAAVAVAGSGGGA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: COX3_ONCCL
Sequence: MAHQAHAYHMVDPSPWPLTGAIAALLLTSGTAVWFHFHSLTLLTLGNILLLLTMYQWWRDIIREGTFQGHHTPPVQKGLRYGMILFITSEVFFFLGFFWAFYHASLAPTPELGGCWPPTGITTLDPFEVPLLNTAVLLASGVTVTWAHHSIMEGERKQTIQALTLTILLGFYFTFLQGMEYYEAPFTIADGVYGSTFFVATGFHGLHVIIGSTFLAVCLLRQVQYHFTSEHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: G6PI_THELI
Sequence: MKYKEPFGVKLDFETGIIENAKKSVRRLSDMKGYFIDEEAWKKMVEEGDPVVYEVYAIEQEEKEGDLNFATTVLYPGKVGNEFFMTKGHYHSKIDRAEVYFALKGKGGMLLQTPEGEARFIEMEPGTIVYVPPYWAHRTINTGDKPFIFLALYPADAGHDYGTIAEKGFSKIVVEENGKVVVKDNPKWRM
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESR1_BOVIN
Sequence: MTMTLHTKASGMALLHQIQANELEPLNRPQLKIPLERPLGEVYMDSSKPAVYNYPEGAAYDFNAAAPASAPVYGQSGLPYGPGSEAAAFGANGLGAFPPLNSVSPSPLVLLHPPPQPLSPFLHPHGQQVPYYLENESSGYAVREAGPPAYYRPNSDNRRQGGRERLASTSDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRNEAVPSGDMRAANLWPSPIMIKHTKKNSPVLSLTADQMISALLEAEPPIIYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLALHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLRSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHFRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPANFGSAPPEDVNQSQLAPTGCTSSHSLQTYYITGEAENFPSTV
What is the function of this protein?
Nuclear hormone receptor.  The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling.  Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components.  Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner.  Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter.  Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP.  Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences.  Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP.  Can activate the transcriptional activity of TFF1.  Also mediates membrane-initiated estrogen signaling involving various kinase cascades.  Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
What are the official names of this protein?
Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Protein: RPPH_SHEDO
Sequence: MIDSDGFRANVGIIICNQYGQVMWARRFGQHSWQFPQGGLDDGESAEEAMYRELYEEVGLRPEQVKILTSTRSWLRYRLPKRLVRQDSKPVCIGQKQKWFLLQLNGNDNNINLNSSGHPEFDDWRWVNYWYPVRQVVSFKRDVYRKVMKEFAPTTLAFQVNDTGRKRNRPRN
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: RF1_FRATW
Sequence: MKDSIKAKLQSLIERHEEVSALLSEAGIISDQNKFRDLSKEYSHLEPIVKAFKEYTQALEDKQAAYEMLNEKDAELVEMAKEELKLANEAIEKLESELQIFLLPRDPNDDANVFLEIRAGTGGDEASIFSGDLFKMYSKYAEQRGWKIEVISASEGEHGGYKEIISRIYGDGVYSQLKFESGAHRVQRVPATESQGRIHTSACTVAVMPEADEVEGIDINPADIKVDTFRASGAGGQHVNKTDSAIRITHIPTGVVVECQDQRSQHKNRAAAMSMLKSKLLQAEIDKQQKEQSDTRKSLVGSGDRSERIRTYNYPQGRVTDHRINLTLYKLDEVMEGSLDSIIQPLVLEHQADLLATMSDE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_ACTP2
Sequence: MSLKPYATPTYWQRVKVAFQYIFPQLPVTRLAGWLAEQKWGAVTHFIIRTFAKQYKVNLSEAQKSNASDYATFNEFFIRPLKENARPINQDAQALCLPADGKVSESGKIEDDRLLQAKGHFFTLETLLANDQEMANKFKDGHFITTYLSPRDYHRVHMPCDATLRKMIYVPGELFSVNPFLAEHVPNLFARNERVICEFETEFGPMVQILVGATITASMSTVWAGIINPPRTKEVVEYHYETSGETAVHLKKGQEMGAFRLGSTVINLFPKDSVEFEAHLQAGVETRMGERLAKIVK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: URE2_ECOLX
Sequence: MIPGEIKVNHALGDIELNAGRETQTIQVANHGDRPIQIGSHYHFYEVNDALKFERENTLGFRLNIPAGMAVRFEPGQSRTVELVAFSGKREIYGFHGKVMGKLESEN
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_ARCFU
Sequence: MRIAEWKEKVESQGCYDAVSEMLERIEKSRLNAYITVCKDEALKMAEKYDRGELKGRLAGIPVAVKDNISTKGILTTCASKMLSNYRPVFDAHVVEKLKQEGAIIIGKANMDEFAMGTTTETSYFGVVRNPHDEARVAGGSSGGSGAVIAADEAVLSLGSDTGGSIRCPASFCGVYGLKPTYGLVSRYGLIPYANSLEQIGPMADSIEDLALLLEVIAGKDTRDSTNAGREFRFEPEDRKLRVGIIAEMGGNDDVMKRFNEAVEVIREKHEVGEVSMPSFKYALAAYYIIAMSEASSNLARYDGVRYGFALEKLDSWRRYFSKVRAEGFGDEVKRRIMLGSYALSAGYYGKYYLKAQKVRTLVIRDFKKAFEEYDVLISPTMPALPFKIGELADPLTMYKADVNTVPVNLAGLPALSVPVGMVKGLPVGLQVIGNYFSENTLLNFGKWVGERFGEGD
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: ZAPC_ALIF1
Sequence: MLKPSDTWTWYYDNKAQSLMLDLGMDMVFCVNLPHKVLVEGAFSECKFSVDDASAYQMFVEHISYLPLSEPRKVELALNCVAAKRFHKPMLPKSWFFETQSDAGYAPEEGEVISLKNDLGEGHFIIVENYECASMCMLVDMDAFALNPTKYMAFCEPIKVMHDRMAPMQVVNSSYYAMVG
What is the function of this protein?
Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ.  Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
What are the official names of this protein?
Cell division protein ZapC.
What is the protein family that this protein belongs to?
Belongs to the ZapC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEAH_SALA4
Sequence: MTWFIDRRLNGKNKSTVNRQRFLRRYKAQIKQSISEAINKRSVTDVDSGESVSIPTDDISEPMFHQGRGGLRHRVHPGNDHFIQNDRIERPQGGGGGGSGSGQGQASQDGEGQDEFVFQISKDEYLDLLFEDLALPNLKKNQHRQLNEYKTHRAGFTSNGVPANISVVRSLQNSLARRTAMTAGKRRELHALETELETISHSEPAQLLEEERLRREIAELRAKIERVPFIDTFDLRYKNYEKRPEPSSQAVMFCLMDVSGSMDQATKDMAKRFYILLYLFLSRTYKNVEVVYIRHHTQAKEVDEHEFFYSQETGGTIVSSALKLMDEVVKERYDPGQWNIYAAQASDGDNWADDSPLCHEILAKKLLPVVRYYSYIEITRRAHQTLWREYEHLQATFDNFAMQHIRDQEDIYPVFRELFQKQSANQSA
What are the official names of this protein?
UPF0229 protein YeaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.