PharMolix/UniProtQA huggingface dataset:
Protein: POXQ_PENO1
Sequence: MARIPLEFLSITLPVLLLAYCLAIEYEVSLPTIAHTSPASNPEEYLQSIYEQLNLDLPSTCTVNHLSAFDNTPTSLLNFSTSPVEHFDAPKLPSGLNATAGEQWAFDGTSSSGRSGLLLGIYRDASYAFLGPGNFRLSLDLVWDNSTTWSTVDYLSSSTVHTCTDKVVGIWSHSADHYYVFTVTADAKHARIHFHTPDVVGAVDLYSTTPARYPDGALFPSEVSVTQNAPMLHWVEPIPGGLIDVDLKVKDTPFRWTGLGGHERWWSAKGWLDLMTHWEAVRLMAGPYVLSFWQPTSRVNGVAYPSAFLTKYGEKVFSAVSGKVSEVEDYILYSPVRMEKQARETGYEVELVSPAQGRRWVFGLEYRNQEFEFELGDAAGGRAYVGRAKGGEVHADDKPEEPSEGVFFIEHVDVKALTVPRAYVVVSFEFGPPIHGADIWVAC
What is the function of this protein?
Diels-Alderase; part of the gene cluster that mediates the biosynthesis of oxaleimides, cytotoxic compounds containing an unusual disubstituted succinimide moiety (PubMed:28365998).  The first step of the pathway is provided by the HR-PKS poxF that serves in a new mode of collaborative biosynthesis with the PKS-NRPS poxE, by providing the olefin containing amino acid substrate via the synthesis of an ACP-bound dec-4-enoate (PubMed:28365998).  The cytochrome P450 monooxygenase poxM-catalyzed oxidation at the alpha-position creates the enzyme-bound 2-hydroxydec-4-enoyl-ACP thioester, which may be prone to spontaneous hydrolysis to yield 2-hydroxydec-4-enoic acid due to increased electrophilicity of the carbonyl (PubMed:28365998).  2-hydroxydec-4-enoic acid can then be further oxidized by poxM to yield the alpha-ketoacid 2-oxodec-4-enoicacid, which is reductively aminated by the aminotransferase poxL to yield (S,E)-2-aminodec-4-enoic acid (PubMed:28365998).  The Hybrid PKS-NRPS synthetase poxE then performs condensation between the octaketide product of its PKS modules and the amino group of (S,E)-2-aminodec-4-enoic acid which is activated and incorporated by the adenylation domain (PubMed:28365998).  The resulting aminoacyl product can be cyclized by the Diels-Alderase PoxQ and reductively released by the reductive (R) domain of poxE to yield an aldehyde intermediate (PubMed:28365998) (Probable).  The released aldehyde is then substrate for a Knoevenagel condensation by the hydrolyase poxO followed by an oxidation at the 5-position of the pyrrolidone ring (PubMed:28365998).  The presence of the olefin from the amino acid building block allows for migration of the substituted allyl group to occur (PubMed:28365998).  This allylic transposition reaction takes place in a conjugate addition, semipinacol-like fashion to yield a succinimide intermediate (PubMed:28365998).  Iterative two-electron oxidations of the C7 methyl of the succinimide intermediate to the carboxylic acid can be catalyzed by one of two remaining cytochrome P450 monooxygenasess poxC or poxD to yield oxaleimide A (PubMed:28365998).  Subsequent oxidation yields the maleimide scaffold oxaleimide I (PubMed:28365998).  Both oxaleimide A and oxaleimide I can undergo oxidative modifications in the decalin ring to yield the series of products oxaleimides B to H (PubMed:28365998).
What are the official names of this protein?
Diels-Alderase poxQ, Oxaleimides biosynthesis cluster protein Q.
What is the protein family that this protein belongs to?
Belongs to the Diels-Alderase family.
Protein: Y0793_MYCTU
Sequence: MTSPVAVIARFMPRPDARSALRALLDAMITPTRAEDGCRSYDLYESADGGELVLFERYRSRIALDEHRGSPHYLNYRAQVGELLTRPVAVTVLAPLDEASA
What is the function of this protein?
Putative monooygenase that might be involved in antibiotic biosynthesis, or may act as reactive oxygen species scavenger that could help in evading host defenses.
What are the official names of this protein?
Putative monooxygenase Rv0793.
Protein: PETG_OENGL
Sequence: MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RSAD1_BOVIN
Sequence: MALPRSQARGWVKAAKMAQRRRPADDTGGPQSPAPGSQRAALYVHWPYCEKRCSYCNFNKYIPRGVDEAALRRCLVIEAQTLLRLSGVRRVESVFFGGGTPSLASPHTVAAVLEAVAQAAHLPADSEVTLEANPTSASGSRLAAFGAAGVNRLSIGLQSLDDTELQLLGRTHSARDALQTLAEAQRLFPGRVSVDLMLGLPAQQVGPWLRQLQGLLRCCDDHVSLYQLSLERGTTLFTQVQQGALPAPDPELAAEMYQEGRAVLREAGFRQYEVSNFARNGALSTHNWTYWQCGQYLGVGPGAHGRFIPQGAGGHTREARIQTLEPDSWMKEVMLFGHGTRRRVPLSELELLEEVLAMGLRTDVGITHQHWQQFEPQLTLWDLFGASKEVKELQEQGLLLLDHRGLRCSWEGLAVLDSLLLSLLSRLQEAWQQRTPSSVPRG
What is the function of this protein?
May be a heme chaperone, appears to bind heme.  Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (By similarity).  Binds 1 [4Fe-4S] cluster.  The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).
What are the official names of this protein?
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial, Putative heme chaperone.
What is the protein family that this protein belongs to?
Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: 3L22_DEMVE
Sequence: MKTLLLTLVVVTIVCLDFGYARTCLKTPEVKSEPCPPGQEVCYTKAWRDRMCSFRGKVIELGCAATCPRQEPGKEITCCSTDDCNTHP
What is the function of this protein?
Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), whereas it binds with a low affinity to neuronal alpha-7/CHRNA7 nAChRs.
What are the official names of this protein?
Long neurotoxin LNTX-2.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: T22D1_MOUSE
Sequence: MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGGGSASALNAAGTGVSGAAPSSEDFPPPSLLQPPPPAASSTQGPQPPPPQSLNLLSQAQLQGQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHHPHHGHHLHHGHHHSSHAAVAGPSIPGGPPSSPVSRKLSTTGSSDGGVPVAPPPAVPSSGLPASVMTNIRTPSTTGSLGINSVTGTSATNNVNIAAVGSFSPSVTNSVHGNANINTSNIPNAASISGGPGVTSVVNSSILSGMGNGTVSSSPVANSVLNAAAGITVGVVSSQQQQQQQQQPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYEKENAVPATEGVAINKVVETVKQTPTEASSSERESTSGSSVSSSVSTLSHYTESVGSGEMMGAPAVVAPQQPPLPPAPPGLQGVALQQLEFSSPAPQSIAAVSMPQSISQSQMSQVQLQPQELSFQQKQTLQPVPLQATMSAATGIQPSPVSVVGVTAAVGQQPSVSSLAQPQLPYSQTAPPVQTPLPGAPPQQLQYGQQQPMVPAQIAPGHGQPVTQNPTSEYVQQQQQPIFQAALSSGQSSSTGTGAGISVIPVAQAQGIQLPGQPTAVQTQPAGAAGQPIGQAQTAVSTVPTGGQIASIGQQANIPTAVQQPSTQVTPSVIQQGAPPSSQVVLPAPTGIIHQGVQTRASSLPQQLVIAPQSTLVTVPPQPQGVETVAQGVVSQQLPTGSPLPSASTISVTNQVSSAAPSGMPSVPTNLVPPQNIAQPPATQNGSLVQSVSQSPLIATNINLPLAQQIPLSSTQFSTQSLAQAIGSQMEDARRPAEPSLGGLPQTMSGDSGGMSAVSDGSSSSLAAPASLFPLKVLPLTTPLVDGEDESSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGSTA
What is the function of this protein?
Transcriptional repressor (By similarity).  Acts on the C-type natriuretic peptide (CNP) promoter (By similarity).
What are the official names of this protein?
TSC22 domain family protein 1, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, TSC22-related inducible leucine zipper 1b, Transforming growth factor beta-1-induced transcript 4 protein.
What is the protein family that this protein belongs to?
Belongs to the TSC-22/Dip/Bun family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CAPSH_ADE16
Sequence: MATPSMMPQWAYMHIAGQDASEYLSPGLVQFARATDTYFSMGNKFRNPTVAPTHDVTTDRSQRLMLRFVPVDREDNTYSYKVRYTLAVGDNRVLDMASTFFDIRGVLDRGPSFKPYSGTAYNSLAPKGAPNTCQWKDSDSKMHTFGVAAMPGVTGKKIEADGLPIGIDSTSGTDTVIYADKTFQPEPQVGNASWVDANGTEEKYGGRALKDTTKMKPCYGSFAKPTNKEGGQANLKDSETAATTPNYDIDLAFFDNKNIAANYDPDIVMYTENVDLQTPDTHIVYKPGTEDTSSESNLGQQAMPNRPNYIGFRDNFIGLMYYNSTGNMGVLAGQASQLNAVVDLQDRNTELSYQLLLDSLGDRTRYFSMWNQAVDSYDPDVRIIENHGVEDELPNYCFPLNGVGFTDTYQGVKVKTDAVAGTSGTQWDKDDTTVSTANEIHGGNPFAMEINIQANLWRSFLYSNVALYLPDSYKYTPSNVTLPENKNTYDYMNGRVVPPSLVDTYVNIGARWSLDAMDNVNPFNHHRNAGLRYRSMLLGNGRYVPFHIQVPQKFFAVKNLLLLPGSYTYVWNFRKDVNMVLQSSLGNDLRVDGATISFTSINLYATFFPMAHNTASTLEAMLRNDTNDQSFNDYLSAANMLYPIPANATNIPISIPSRNWAAFRGWSFTRLKTKETPSLGSGFDPYFVYSGSIPYLDGTFYLNHTFKKVSIMFDSSVSWPGNDRLLSPNEFEIKRTVDGEGYNVAQCNMTKDWFLVQMLANYNIGYQGFYIPEGYKDRMYSFFRNFQPMSRQVVDEVNYTDYKAVTLPYQHNNSGFVGYLAPTMRQGEPYPANYPYPLIGTTAVKSVTQKKFLCDRTMWRIPFSSNFMSMGALTDLGQNLLYANSAHALDMTFEVDPMDEPTLLSLVFEVFDVVRVHQPHRGVIEAVYLRTPFSAGNATT
What is the function of this protein?
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid.  Assembled into trimeric units with the help of the chaperone shutoff protein.  Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid.  Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
What are the official names of this protein?
Hexon protein, CP-H, Protein II.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae hexon protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.
Protein: SUCC_ALCBS
Sequence: MNLHEYQSKQLFADYGLPVSTGFACDTPEEVAAKAKEIGGDKWVVKAQVHAGGRGKAGGVKLVDTPEDAAAFAKKWLGKQLVTFQTDEHGQPVSKILVETCTDIAKELYLSAVLDRASRRVVFMASTEGGVDIETVAEETPEKILKAEIDPLVGAQPYQAREIAFKLGLEGKQVNQFAKIFVGLAKLFVDKDLALIEVNPLVITDTGDLHCLDAKINVDGSALYRHPDIKALDDPSQEDERERRAAEWDLNYVALEGNIGCMVNGAGLAMGTMDLVKLKGGAPANFLDVGGGATKERVTEAFKIILSDDQVKGVLVNIFGGIVRCDLIAEGIIGAVEEVGVTVPVVVRLEGNNAELGSQKLAESGMNIIAAQSFDDAAEQVVKAVGGAA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: CCNA_HYDVD
Sequence: LFFQKKYFLDKQLNQNAIQIYQDNLTNQNNNIGKKAKLEDEKHAHNKSITSKYKRVPLASISNVQGSRIQPTRAAKEKLKPPQNISDSQLVNDSLKSSNSIQAHNTKNDLHKENLYNESALDTFKESPMVFSPFLSDSSCKKYSSLNGIQDIDSKLHEVFELPEYAQDIHNYLKKSEAKYRPKSNYMRKQTDINSSMRAILIDWLVEVSEEYKLIPQTLYLSVSYIDRFLSHMSVLRGKLQLVGAACMLVAAKFEEIYPPEVAEFVYITDDTYTAKQVLRMEHLILKTLAFDLSVPTCRDFLSRYLFAANAKPESQLKYLAEYLSELTLINCDISVKYAPSMIAASSICVANHMLNSIPWTPTLEFYSGYNIQDLRSCLNEIHLLHLAASTNPQQAIQQKYKSPKFGCVSSLVPLEMPCF
What is the function of this protein?
Essential for the control of the cell cycle at the G2/M (mitosis) transition.  Interacts with the CDC2 and CDK2 protein kinases to form MPF.  G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (By similarity).
What are the official names of this protein?
G2/mitotic-specific cyclin-A.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: LOVG_ASPTE
Sequence: MRYQASPALVKAPRALLCIHGAGCSPAIFRVQLSKLRAALRENFEFVYVTAPFPSSAGPGILPVFADLGPYYSWFESSSDNNHNGPSVSERLAAVHDPIRRTIVDWQTQHPHIPIVGAIGFSEGALVTTLLLWQQQMGHLPWLPRMSVALLICPWYQDEASQYMRNEVMKNHDDDNDSKDTEWQEELVIRIPTLHLQGRDDFALAGSKMLVARHFSPREAQVLEFAGQHQFPNRPRDVLEVINRFRKLCVTAQTLE
What is the function of this protein?
Esterase that catalyzes the release of covalently bound dihydromonacolin L from LovB during lovastatin biosynthesis.
What are the official names of this protein?
Dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase, Esterase lovG, Lovastatin biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the LovG family.
Protein: U76E1_ARATH
Sequence: MEELGVKRRIVLVPVPAQGHVTPIMQLGKALYSKGFSITVVLTQYNRVSSSKDFSDFHFLTIPGSLTESDLKNLGPFKFLFKLNQICEASFKQCIGQLLQEQGNDIACVVYDEYMYFSQAAVKEFQLPSVLFSTTSATAFVCRSVLSRVNAESFLLDMKDPKVSDKEFPGLHPLRYKDLPTSAFGPLESILKVYSETVNIRTASAVIINSTSCLESSSLAWLQKQLQVPVYPIGPLHIAASAPSSLLEEDRSCLEWLNKQKIGSVIYISLGSLALMETKDMLEMAWGLRNSNQPFLWVIRPGSIPGSEWTESLPEEFSRLVSERGYIVKWAPQIEVLRHPAVGGFWSHCGWNSTLESIGEGVPMICRPFTGDQKVNARYLERVWRIGVQLEGELDKGTVERAVERLIMDEEGAEMRKRVINLKEKLQASVKSRGSSFSSLDNFVNSLKMMNFM
What is the function of this protein?
Possesses low quercetin 3-O-glucosyltransferase and 7-O-glucosyltransferase activities in vitro.
What are the official names of this protein?
UDP-glycosyltransferase 76E1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: HEMH_BRASB
Sequence: MTAAISFDNARSPDNALPLPAASTARVGVLLVNLGTPDTADAAGVRVYLKEFLSDRRVIEDQGLLWKIILNGIILNVRPRKKAKDYQSIWNTEKNESPLKTITRAQSEKLSAALADRSHVIVDWAMRYGNPSIKAGVDGLMAKGCDRILVVPLYPQYSAATSATVCDEAFRVLTELRAQPTLRVTPPYYNDDFYIEALAVSIEEHLKTLSYKPELIVASFHGMPKEYVDKGDPYREQCVATTELLRKRLGMDDTKLLLTFQSRFGFSEWLQPYTDKTIEKLAKDGVKRIAVVMPGFAADCLETLEEISGENCEIFKHNGGEEFSAVPCLNDSAPGMEVLRQLVLRELQGWL
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BOKB_DANRE
Sequence: MNVFARSSVLAAEMIDVFDRTHTEKELVFQSKELCRDFIHSRITREGLSWSKVELDLPEPRGVLVDVSVVLLKLGDELECMRPYVYRNIAKQLNISVSVEAVVSDAFLSVATEVIAMGITWGKVVAIYAVAAGLAVDCVRLGHPVMVHTIVDSLGEFVRRSLVPWLKKRGGWVDILKCVVNMDSRAHVHWLSTAVLTWREFIKTMYVYLTK
What is the function of this protein?
May play a role in apoptosis.  Does not appear to show pro-apoptotic activity when expressed ectopically in early embryos.
What are the official names of this protein?
Bcl-2-related ovarian killer protein homolog B, zBok2.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: MTNB_TALSN
Sequence: MPEATNIQVVIASGLDNEENNDHLVQSSDPQHPANLIPEMCRKFYTWGWVTGTGGGTSIRHGDHIFIAPSGVQKELIQPENIFVMQFPTPKYPPSERKYIRKPKNLKPSDCTPLFLTAFERGAMCCIHTHSQWAVLVTLLVERIYGKEAHFEISNIEQIKGIPKGKGKGMHNYHDTLRIPIIDNTPFEEDLTEGLERAIAANPDTYAVLVRRHGIYVWGDTPAKAKTQCESLDWLFQLAVEMHKLGLPWDINKTK
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_MESH2
Sequence: MKKVSRNLLQARQMVDKNRFYSLEEAMELVKKTSYTKFSGSVDLAIRLNLDTRKADQQLRGAVVLPHGTGKSVRVLVATDSSEVAAKSLEAGADLIYSTAELEQNLKIDNFNFDVIVVEPKLMPILGRYGKKLGPKGLMPNPKTGTVSPNPEKAVAEIKKGKANYRADRYGIIHSLIGKTNMEVPQLVENANTLLRLIKRLKPNTVKGNYFKNLTVSASMGPSIKIRFDNL
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: ACT_COLSC
Sequence: MADGEEVSALVCDNGSGMVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFSVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYAFTTTAEREIVRDIKEKLAYVALDFEQEMQTAQNSSSLEKSYELPDGQVITIGSERFRCPEVLFNPALIGMESAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWIAKSEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: GCS21_LEGPC
Sequence: MRLLSFKKSKIVSIGTELEFQIIDRSSLSLVSRSKELMRALKDMRYRDQIKPEITQSMIEINSSIHQSAKEMYDELLELQKILVETAASIDIAFCGGGTHPFQQWTMQKIFPSKRFKKKFNQYRYLSKRATVFGQHIHIGCPTGDDAIYLTHALARYVPHFIAISASSPFYLGINTNYCSSRSTIFNAFPLSGVIPYLRNWQEFSDYYRKMYRWKIIENMKDFYWDIRPKPELGTIEIRVCDTPLTLRKSILITAYIQALALYLLKEKPVQLSHDLYYVYNYNRFQASRHGLEGELTVTDKDKPILIMDDILETIKKIEQYINGLGNSEYIEELYSDVINKQNDSVLINKIYKQDGSFTKLVAAQCELWLSDSKDRKWMTQPS
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2-1, Gamma-glutamylcysteine synthetase 2-1, GCS 2-1, Gamma-GCS 2-1.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: NEC1_HHV6U
Sequence: MTVHKSRIRRSRSLSVTHRIQKRPDHREKTKLYLQLKLHDLHTVFNLFPEYEQKFLAIIKLPITGKEPIDVPFSLSNHHQHTCLEFSPYANEQISKSACLHCESVSVPTSSDAMVAHLNQVNNVMQNRLYFYGFRKDMELIRMSAKQPTIFQIFYIVHNTINNIFPIMFERKQKLGMHIVFQSRTLHIPCECIKQIVAVSSGYNVYLDILQESVILTVLCETLDTNTNIHIDIGMLQKKLEEMDIPNEISDRLEKYKGHLIGFH
What is the function of this protein?
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell.  Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2.  Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space.  There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
What are the official names of this protein?
Nuclear egress protein 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae NEC1 protein family.
What are the subcellular locations of this protein?
Host nucleus inner membrane. Note=Remains attached to the nucleus inner membrane through interaction with NEC2.
Protein: SYS_STRPI
Sequence: MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKKIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTGARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLTNYYRDEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVALSTGDMGFSAAKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEALRPYMGGAEVIKP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERC_RUTMC
Sequence: MSQVYNFSAGPAMLPTQVLKQMQDELLEYGNTKASVMEISHRDPYFIAMAQKLEQDLRDLMGIPNHYKVLFLQGGASAQFSMVPINLLQGKTKANYAHTGHWSKKAITEGKRYCEVNICTDSSDNKYTDIDVFENWNIDPDGAYLHYTPNETIAGLEFDYVPEVDMPLVADMSSSILSREVDVSKYGVIYASAQKNIGIAGLTIVIVRENLMGNVLANQPVLFDYTTQANNDSMYNTPSTYSWYAASRVFEWLKQQGGLSAMAKINQTKAKTLYDAINGSDFYSNPVAIKYRSWMNVPFLLADESLNGFFLEKAIANNLITLKGHRSVGGMRASIYNAMPQDGINELVNFMKVFEKENT
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMCL2_MOUSE
Sequence: MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK
What is the function of this protein?
Possible function in spermatogenesis.  Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
Germ cell-less protein-like 2, BTB domain containing 35, family member 1, Germ cell-less protein-like 1-like, mGclh.
What are the subcellular locations of this protein?
Nucleus matrix.
Protein: GCSPB_THEMA
Sequence: MTIFERSKKGRKAFRLPESDIPEYSLPDRFLRRTPPELPEVSEPDLVRHYTNLARKNYSVDLGIYPLGSCTMKYNPKLNEKAANLEGFREIHPYQPVETVQGSLRLMYELKKMLCEITGMDDMTLQPAAGAHGELTGMLIVREYFKNRGDTGRKKVLVPDSAHGTNPASASMVGFEVVEIKSKNGMVDVEDLKKLLDEEVAAVMLTNPNTLGLFEKDILKIAEMTHECGALLYYDGANLNAIMGKVRPGDMGFDIVHLNLHKTFSTPHGMGGPGSGPVGVKKHLVDFLPFPQVKKNGELYELFVPEKTIGRVRSFFGNFPVLVKAYTYILTMGRDGLERVSEMAVLNANYLKKKIEKFLEIPYNGFCMHEFVASAEKVFRETGVRTLDIAKRILDFGVHPPTVYFPLIVPEALMIEPTETENKETLDKYAEILERVVKEAYENPDALKNAPHNTPVRRVNEVLASKKPVFRWRG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: SPXH_BACAN
Sequence: MDKQEAKHINMPSPSACEYKSVEAYLFIDPLCKDCWEIEPFIIKLWLEYGKYFSIRHIVTGKVDGTNASSHKWNKPANIRFVWEKTTSLHGFSYDGKVHMQEASSTPYLVSMAIKAAELQGRKAGSKFLRKLQEYIFLENVSNPDCELLLACAKDSDIDVEEFKKDLYSASAKKAFQCDLKFTNEMHITEIPSLVFFHANSDEEGIKIAGTYSYDVYVQLLKELVKCEIEPEPLPSLEVLLEATQFISSKEVAFIYDCSKQEIERELKKLQLKRKVQMIDVKCERYWKWIAKEKDLV
What is the function of this protein?
Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions.  Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP.
What are the official names of this protein?
ClpXP adapter protein SpxH.
What is the protein family that this protein belongs to?
Belongs to the SpxH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC31_DESAC
Sequence: ADSLTQFDGIKGRYSHEAFYEEKACDSCHLNK
What is the function of this protein?
Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin.
What are the official names of this protein?
Cytochrome c3, 10 kDa.
What are the subcellular locations of this protein?
Periplasm.