PharMolix/UniProtQA huggingface dataset:
Protein: PDXH_PSEA7
Sequence: MTQSLADMRREYTRDGLSEANAPSDPFSLFRQWFDDAVKTERLPVEPNAMTLATVDADGHPHCRILLLKGLDERGFTFFTNYESAKGRQLAANPRAAMTFFWPALERQVRIEGEIEKVTAQESDAYYQVRPLGSRLGAWASPQSRVIADRAELERLLAETERRFADQAPSCPEHWGGYRLLPQRIEFWQGRPSRLHDRLDYRHQDGVWARERLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: ATPF_SALAI
Sequence: MFFLAAEGGETSHSPILPVWQEIVVGLVAFGLLAFVLMKFVFPRMEQTFQARVDAIEGGIKRAEAAQAEANQLLEQYRAQLSEARSDAAKIRDDARADAEGIRQDILAKAREESDRIIAAGKEQLVAERATIVRELRTEVGTLAVDLASKIVGESLADEARRAGTVDRFLDGLESAGAR
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: EFTS_CALS8
Sequence: MISAEMVKELRERTGAGMMDCKKALEDANGDMEKAIELLRERGLAKAAKRASRVAAEGIVESYIHGNGRIGVLVEINCETDFVARNEEFRQFAKDIAMQIAAANPKYVSREEIPQEVIEREKAILRQQALNEGKPENVVDRIIEGRLEKFFEEVCLLEQPWIKNPDMKIKDLLTEKIAKIGENIVIRRFARFERGEGIEKAASC
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU2M_MORBE
Sequence: MNPLIMSIILATIILGTTIVMTGSHWLMIWIGFEMNMLAIIPMLMKQHNPRSTEAATKYFFTQATASMLLMLAGIINLMYSGQWTGVKLVNPTASIIMTLALAMKLGLAPFHFWVPEVTQGIPLSSGLILLTWQKLASMTGLYMISPGINLNMLMTMSMLSIAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAILIYNPTMTLLNLVIYILMTTTMFMLFMINSSTTTLSLSHTWNKMPLITTTTLVTLLSMGGLPPLMGFLPKWMIIQEMTKNNNIVLPTIMAITALLNLFFYMRLTYATSLTMFPTTNNMKIKWQFENPKYLSLLTPMIMMSTLTLPLAPMMMILN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SERB_CAMJD
Sequence: MIKLCVFDFDATLMDGETIDILATAHGKGNQISEITRYAMAGELDFFESLQKRVSFLKGMSYKKVLELGSTLPLMHGAHELIQYLKSKNIQIVIFSGGFHEGIDPAMQKLGINLGFANYLHHKNDILTGLIGGEIMFSNSKGLMLQRLKSFLNLKTDEVMCVGDGANDLAMFNESGLKIAFCAKEILRSQADICIDIKDLKEIIKVI
What are the official names of this protein?
Phosphoserine phosphatase, PSP, PSPase, O-phosphoserine phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. SerB family.
Protein: Y4182_POLSJ
Sequence: MPAALLPGAGCPCGRLGASGKPLAFAQCCGRYLDDFAGTPAPDAESLMRSRYCAFVRERADYLLATWHASQRPPSIDFDPGVKWLGLEVRQHRQLDATHAEVEFVARQKSPGSPAVRLHERSRFVHEAGRWYYVDGDTR
What are the official names of this protein?
UPF0225 protein Bpro_4182.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: CAPSD_BNYVS
Sequence: MSSEGRYMTWKDMSHNKFMTDRWARVSDVVSVIKQSHAMDLSKAANLSIIKTALAGLGSGWTDNNPFVSPMTRFPQTLTMYGALVLYVNLSDPEFALIMTKVSTLTDSGLADNASANVRRDVVSGNKAESSGKTAGTNENSAYTLTVSLAGLAQALRLEELMWTRDKFEDRLKLPWTPVQGRTSPPGQXQLAAARVTAHIRAAKRALLYPGDSPEWVGWKHFYPPPPYDVYDVPPLDIINAKLAADDIGGLVTPTPASSHGLPFEVSEEVEQANRNSLWLTVGLLLAALAVGIGVAAYHRKKLQSRLRELKLLWGSTGGSGGGGGFDTELYMRATDTVSLGTTLSEHAASAPSGLRHRPAATDSGPHEALPFEVWVFDNLAVVYDSIGMSDLFYTVREFVGVFNGEFEGLIELLESPDDDDGVYTNAPRDTAIDAYESQENYDRIDIETVLIERRINLKKLLLEEAELERRERDMTMIADEEQRTLLHRLESSRVEATHAVAKAEADARAAVAMAALASKEANDYDSKMAFDRSCKEQELRLRELEVNSMPSKTERYVHTGIQGGAQLAGAMAVGAMLRRGAGSSSQTVSSGANIGSRSQSLTRGRSASQPLSSVGGSTRGVNNNISNTNLVRAGNSAEVSAGRSTNSGNSNFWSKLRVGEGWSKYSVERAATRAQRAIVLPAPPSAPAG
What is the function of this protein?
Minor capsid protein involved in virus transmission by the vector S. subterranea.
What are the official names of this protein?
Capsid readthrough protein, CP-RT.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
[Capsid readthrough protein]: Virion. Note=Associated with one extremity of viral particles. SUBCELLULAR LOCATION: [Isoform Capsid protein]: Virion.
Protein: TOPZ1_MACFA
Sequence: MRRPPPLGPTTASGPEGNVRNLRKRQAPGPGAAGGCGPEAGGRGENRQKRRMVARATPGRGEVKSDKSVAASGAGKAARRRVEGRRGQVSPSDRRGLEAAKEAEFPLQTERHTKEKRKVTEASSDDPQPGFDLVRKESLTSSESFQTVECLRSLGKEGIVEGIKRRIRNKKLKSLENPPLKITENEATQNIKVEFQDELYKNTLKYSCNILSPEVENNFVFKLRDCNCFPHSKDCNDENNLPYEPDGGCMHVAENFSKKENFRSLAEKSDTNNIPQLLQTEENVMGVNKLLPEESDLYQSKINGLLPCLQREKNKYSIEESSVGRKPRKRMKLSEKADETVTQMNFSNEYNKSELMLQENQMIADGKEAEAKSPLNVLRKVSHNTVSLMDHLLSVPEMVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGYENMALKEDFKSKSCIGKSPEYHIERRSSREDLRSDSEELKLSCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLPGSQKSCKKVDVPKHQTNKTHLTDSKLLLQSSLTETNTESSSKEKLDSNLNCLFSVSAVEHTLMVIKEPIIKDDKKIKSEELSRSGSEVISNTTEDTQLTSDTQSLTGNKKRDRGNLTKLNLTAASKDGQEANNSTGKTIHRKACVAKQTFVVPDLVKILNTGRLTNFKIPLLKNKTKKRKEVNAKSSEREGYSPLELLDNLSGADTRQNRSKENVSMTMLGPQTLSIQNSVTPVQASSDSFYNKNSCSISPSFTKHGNSSKPSNHFSEPGNIVSNKEVASLTVENNAFSCDPGYVEKSPSFCCNKQETFRPVSSEVRGRKITKNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFGVSNEGELSFTSEVPRISQEPNVPGEHQSTDSKYVETPVKKEPSDDLRELPVLDCGPIKPDICASNSAASEIKHDPKDANTSLGEVANETSENETLGDFSEQIKGSDLDEKHRFTDKVITKEEKENIYEVRKSKDSRNADIMVGECQFAAPVPKPLCLLVPPLNLSGHQEDTILNTWMNDFRFLGKHSVLKLQNPETCEIFKREKNVGVFQKSLGLMIPYKYCKFHFNTLRGCERPLCKFAHVPEQGDEKVCMDVFKKYININELCLLQRAVNVFMEYYRKFPPGIYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKMLPSLKILLNIFEHVATMKLRNAVPALIDIFCKLVEAGMVLDPEHFNYIVKLLYQVQASKQEITAVLEMKSRLQMRQFKKNWKCDLDSALNKLEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFCACIAETLTKNCEDERPDTPFCEFAETVSKDPQNSKVDKGVLGRIGISAMYFYHKLLQWSKGRKVLDKLYELKIHFASLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGALWVMRESEWIIDTPLWPCDRLDVLNRHNLLCTIAHETLAKSLYRQTFEVLQNLPGFQNSQETVEVSQYSLLFNKLLGSCIESNSLGMSSSVAEFMISKSIPIDFSFLRRLITSLGRSRLWLKARAHYKSALSLGCYPPLEGNLYRKLLLIPSYLSEIEMLLAIEIFMVSNASSIQSPGTSTQILQIVLKRCEDNQSRSNDDYQAAVERLIMAARISDPKLFVKHMTVNVNKEQVYSLEHCSALKWLKENMKWAGKVWLFSNH
What is the function of this protein?
Important for normal spermatogenesis and male fertility.  Specifically required for progression to the post-meiotic stages of spermatocyte development.  Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
What are the official names of this protein?
Protein TOPAZ1, Testis- and ovary-specific PAZ domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HIS8_ECO24
Sequence: MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPTLDNWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAIVVADEAYIEFCPQASLTGWLAEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVTQIIAEREYLIAALKEIPCVEQVFDSETNYILARFKASSTVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQRVIDALRAEQV
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: TAL_THEP1
Sequence: MKIFLDTANLEEIKKGVEWGIVDGVTTNPTLISKEGAEFKQRVKEICDLVKGPVSAEVVSLDYEGMVREARELAQLSEYVVIKIPMTPDGIRAVKTLSAEGIKTNVTLVFSPAQAILAAKAGATYVSPFIGRMDDLSNDGMRMLGEIVEIYDNYGFETEIIAASIRHPMHVVEAALMGVDIVTMPFAVLEKLFKHPMTDLGIERFMNDWKKYLENLKK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YH214_YEAST
Sequence: MFNRFNKFQAAVALALLSRGALGDSYTNSTSSADLSSITSVSSASASATASDSLSSSDGTVYLPSTTISGDLTVTGKVIATEAVEVAAGGKLTLLDGEKYVFSSDLKVHGDLVVEKSEASYEGTAFDVSGETFEVSGNFSAEETGAVSASIYSFTPSSFKSSGDISLSLSKAKKGEVTFSPYSNAGTFSLSNAILNGGSVSGL
What are the official names of this protein?
Putative GPI-anchored protein YHR214W.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: GBPA_VIBVU
Sequence: MKKQPQKTLLAIALSVVSGTAMSHGYVSAVENGVAEARVTLCKFAASTGEKNTNCGAIQYEPQSVEGPDGFPASGPRDGKIASAESALANALDEQTADRWVKRPIQAGAQNFEWTFTANHVTKDWKYYITKPDWNPNQPLARASFDLTPFCVVDGGMVQPPKRVSHTCNVPEREGYQVILAVWDVGDTAASFYNVIDVKFDGDGPALPDWQQGGQIIPTMNLNVGDTVFTRVFDLAGENPAYTTELAIDSDALTVANNWSHALAVKINQTQSEIAAGQLNEQNQFVPVYGTNPIFLKSGSNLQRVEIGYKIETPAPEYDVTLSGLASEYQIGDAPVTLDLGLQATGDITTELTIYNHHKEPLAFETVAMTDGENKAVSMTLSKSEAGHHMLVTKVLDKDGTLQKQQTSDFMLTETQTPPPSDDYDFVFPDGLSSYTADTKVLASDGAIYQCKPFPYSGYCVQWTPTATQYQPGTGSHWQMAWDKL
What is the function of this protein?
Probably interacts with GlcNAc residues.  May promote attachment to both epithelial cell surfaces and chitin.
What are the official names of this protein?
GlcNAc-binding protein A.
What is the protein family that this protein belongs to?
Belongs to the GbpA family.
What are the subcellular locations of this protein?
Secreted.
Protein: FMA6_DICNO
Sequence: MKSLQKGFTLIELMIVVAIIGILAAFAIPAYNDYIARSQAAEGVSLADGLKVRIAENLQDGECKGPDADPASGVVGNKDTGKYALAEIDGTYDASKTAAGDPNGCKVNITYGQGTAADKISKLITGKKLVLDQLVNGSFIQGDGTDLADKFIPNAVKAKK
What are the official names of this protein?
Fimbrial protein, Pilin, Serogroup B1/AC6.
What is the protein family that this protein belongs to?
Belongs to the N-Me-Phe pilin family.
What are the subcellular locations of this protein?
Fimbrium. Membrane; Single-pass membrane protein.
Protein: LEU1_RHOPT
Sequence: MTTTTQSEQDRVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDGDFEAVHEIAKRSKNSVICGLSRAAHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYRELFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGIGERAGNAALEEVVMAMRVRQDKLPYWNRIETTMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKMEELGYKLSRNQIEDVFVRFKALADRKKDVYDEDIEALVDEQLLHGQDQIKLMSLTVIAGTHGPQRATMKLDVDGQIRIEEAEGNGPVDAVFNCIKALVPHDAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQRSVREDAPTVAVAG
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: CATD_CHICK
Sequence: MAPRGLLVLLLLALVGPCAALIRIPLTKFTSTRRMLTEVGSEIPDMNAITQFLKFKLGFADLAEPTPEILKNYMDAQYYGEIGIGTPPQKFTVVFDTGSSNLWVPSVHCHLLDIACLLHHKYDASKSSTYVENGTEFAIHYGTGSLSGFLSQDTVTLGNLKIKNQIFGEAVKQPGITFIAAKFDGILGMAFPRISVDKVTPFFDNVMQQKLIEKNIFSFYLNRDPTAQPGGELLLGGTDPKYYSGDFSWVNVTRKAYWQVHMDSVDVANGLTLCKGGCEAIVDTGTSLITGPTKEVKELQTAIGAKPLIKGQYVISCDKISSLPVVTLMLGGKPYQLTGEQYVFKVSAQGETICLSGFSGLDVPPPGGPLWILGDVFIGPYYTVFDRDNDSVGFAKCV
What is the function of this protein?
Acid protease active in intracellular protein breakdown.  In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL.
What are the official names of this protein?
Cathepsin D.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: DDIT4_BOVIN
Sequence: MPSLWDRFSSSSSSSSLSRTPTPNQPPRSAWGSAAREEGLGRCGSLESSDCESLDSSNSGFGPEEDSAYLDGVSLPDFELLSDPEDEHLCASLMQLLQESLAQARLGSRRPARLLMPGQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVGQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLFSSANSPFVPGFSQSLTLSTGFRVIKKKLYSSEQLLIEEC
What is the function of this protein?
Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1).  Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB.  Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage.  Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity.  Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes.  Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity.  Required for normal neuron migration during embryonic brain development.  Plays a role in neuronal cell death.  Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).
What are the official names of this protein?
DNA damage-inducible transcript 4 protein.
What is the protein family that this protein belongs to?
Belongs to the DDIT4 family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm, cytosol.
Protein: CYB_UROWA
Sequence: MTKTRKTHPLXKIINHSFIDLPAPSNISAWWNFGSLLGLCLAIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTYFETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFVLPFIIAALVMVHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDILGVLLLISALMTLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILMLFPLLHLSKQRSMMFRPLSQCMFWILVADLFTLTWIGGQPVEYPFVIIGQLASILYFTIILLILPTVSLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SMAD4_BOVIN
Sequence: MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPPSMLVKDEYVHDFEGQPSLSTEGHSIQTIQHPPSNRASTETYSTPALLAPSESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGGRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
What is the function of this protein?
Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor).  Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling.  Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription.  Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta.  Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.  Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions.  May act as a tumor suppressor.  Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.  In muscle physiology, plays a central role in the balance between atrophy and hypertrophy.  When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4.  MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity).
What are the official names of this protein?
Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, SMAD family member 4, SMAD 4, Smad4.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation in response to TGF-beta.
Protein: S10A4_RAT
Sequence: MARPLEEALDVIVSTFHKYSGNEGDKFKLNKTELKELLTRELPSFLGRRTDEAAFQKLMNNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGCPDKEPRKK
What is the function of this protein?
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy.  Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity).  Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity).  Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity).  Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity).  In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity).
What are the official names of this protein?
Protein S100-A4, Metastasin, Nerve growth factor-induced protein 42A, P9K, Placental calcium-binding protein, S100 calcium-binding protein A4.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
What are the subcellular locations of this protein?
Secreted. Nucleus. Cytoplasm.
Protein: CWC24_YEAST
Sequence: MFRKRLVNKSSSDEKNQKKRQKINFSEEKLVASDEEKGSSDLMSLAKSGNSRTLQLSHENEGKLQKKGEDLDKYTLTVNDDSTKEDLLNFERKELAEKAKKRRPSDDNELVLNMSGKNKRLTKQINQPTNIRTTVLMDFQPDVCKDYKQTGYCGYGDSCKFLHSRDDFKTGWKLNQEWNADKEDSKAVTLDLEKIPFKCTLCKEDYKSPVVTNCGHYFCGSCFAKDMKKGTKCFICHKETHGSAKVASDLQKMLNKRKS
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC24, Complexed with CEF1 protein 24.
What is the protein family that this protein belongs to?
Belongs to the CWC24 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR15_CERDE
Sequence: MIKNSFISVIPQEDKKRKRGGSVEFQVFNFTNKIRILTSHLELHRKDYSSQRGLRKILGKRQRLLAYLSKKNRVRYKELIGQLDIREPKTR
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y1733_MYCTO
Sequence: MIATTRDREGATMITFRLRLPCRTILRVFSRNSLVRGTDRLEAVVMLLAVTVSLLTIPFAAAAGTAVHDSRSHVYAHQAQTRHPATATVIDHEGVIDSNTTATSAPPRTKITVPARWVVNGIERSGEVNAKPGTKSGDRVGIWVDSAGQLVDEPAPPARAIADAALAALGLWLSVAAVAGALLALTRAILIRVRNASWQHDIDSLFCTQR
What are the official names of this protein?
Probable membrane protein MT1774.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PRIM_VZVD
Sequence: MDKSSKPTIRLLFATKGCAISHSLLLLTGQISTEPLYVVSYTWTPDLDDVFVKNGREEITQVIPTKRPREVTENDEENQIMHLFCSRDVNVIFYLIGGFSTGDVRSRVWPIFFCCFKTQTDFKALYKALWYGAPLNPHIISDTLCISETFDIHSEVIQTLMVTTHHLNRKGLSDNGLCITEATLCKLVKKSVGRQELTSLYAHYERQVLAAYRRLYWGYGCSPFWYIVRFGPSEKTLVLATRYYLLQTDTSYNTLETPLYDLQAIKDLFLTYQVPALPNCSGYNISDLLSFDKLSMFCCSSTYTRGLTAKNALSYILQRIHTDTTEIHAVSEYITNDRKGLKVPDREFVDYIYLAHFECFNRKQIADHLQAVTYSDFVNKPVLLKSSNLGKRATANFFNHVRSRLNMRDYIKKNVICDVTELGPEIGHKYTITKTYTLSLTYAAKPSKFIGVCDLATTLTRRVENIEKQFSPYGWSSTIPSNPPGFDELSNFEDSGVSAEALRAANFANDTPNQSGRTGFDTSPGITKLLLFFSAATGIATHDVSILSYKTPLEALIGHSEVTGPMPVYRVALPHGAQAFAVIANDTWSSITNRYTLPHEARLIAEDLKQINPCNFVAASLRDMQLTLLLSTSVKNVSKISSNIPKDQLYINRNELFNTNLIITNLILDVDFHIRKPIPLGILHAGMRAFRHGILTAMQLLFPKAVVNPNKDPCYFYKTACPEPTVEVLDDDNLLDITSHSDIDFYIENGELYTCVEENYTEDVWFFDTQTTSEVHTHADVSNNENLHETLPCNCKEKIGFRVCVPIPNPYALVGSSTLKGFAQILQQAVLLEREFVEYIGPYLRDFSFIDTGVYSHGHSLRLPFFSKVTTTGTAVGQLLPFYVVPEQCIDILAFVTSHRNPANFHFHSRPQSNVPVQFILHNLGGEYAEFFERKVARNKQIFSSPQISLTKALKERGVTCLDAFTLEAFVDSTILESIVEHIAVHFPGRDREYTLTSSKCIAIKRDWVLFQLICGTKGFTCLRYPHRGGRTAPRTFVSLRVDHHNRLCISLAQQCFATKCDSNRMHTIFTLEVPNYPNLTSS
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Protein: VPB28_MYCTO
Sequence: MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLPA
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Antitoxin VapB28.
Protein: HSP1_MONRE
Sequence: MARYRCCRSPSRSRCRRRRRRCRRRRRRCCRRRRRVCCRRYTVRCRRR
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: XYNA_TALFU
Sequence: MSALNSFNMYKSALILGSLLATAGAQQIGTYTAETHPSLSWSTCKSGGSCTTNSGAITLDANWRWVHGVNTSTNCYTGNTWNTAICDTDASCAQDCALDGADYSGTYGITTSGNSLRLNFVTGSNVGSRTYLMADNTHYQIFDLLNQEFTFTVDVSNLPCGLNGALYFVTMDADGGVSKYPNNKAGAQYGVGYCDSQCPRDLKFIAGQANVEGWTPSTNNSNTGIGNHGSCCAELDIWEANSISEALTPHPCDTPGLTVCTADDCGGTYSSNRYAGTCDPDGCDFNPYRLGVTDFYGSGKTVDTTKPFTVVTQFVTDDGTSSGSLSEIRRYYVQNGVVIPQPSSKISGISGNVINSDFCAAELSAFGETASFTNHGGLKNMGSALEAGMVLVMSLWDDYSVNMLWLDSTYPANETGTPGAARGSCPTTSGNPKTVESQSGSSYVVFSDIKVGPFNSTFSGGTSTGGSTTTTASGTTSTKASTTSTSSTSTGTGVAAHWGQCGGQGWTGPTTCASGTTCTVVNPYYSQCL
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
1,4-beta-D-glucan cellobiohydrolase xynA, Beta-glucancellobiohydrolase xynA, Exocellobiohydrolase xynA, Exoglucanase xynA.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.