PharMolix/UniProtQA huggingface dataset:
Protein: T10IP_BOVIN
Sequence: MGQETNMLNAHQQLVRTSSGRPGHDKRQQTPGTATGLLKLLSSTPYAEQRSLGSGDGVIHAQKQRSRSAGQTPKKDRRLRGRNKKGQSSAEAEDVVPSSPRKPSFPFQWAWESFTTDGRALHQPSSVLAPGHQALPLPLAVHHHKSRRKSTPALPEAHSFCWKTEEPNLERRQQLRACSCTSIPPGRGTSQELEPSGEGGLQSPRKSSGSGLEPEESEPEGLGAEEAERGLIPGELPQLPRRGLILEEEQFSEATEEAEDGEHRAPWRRRTSSRRKGRNSGEEAWEESEVRRLESVSSSTNLREPQRRKPRAKELEGPWDLEKLQRKLQQELDCGPEKQPWKSLRAAVQASNWSRKAHPLGDDETFLFANFPNRTFHKRQEATRNLLRAWELQQREEQQQAEVRRAREQRVQHQVARCLAAYAPRGSRGPGAAQRKLEELRRQERQRFVEYQAELQGIQHRVQARPYLFQQAMQANARLNVTRRFSQVLSALGLDEEQLLAKAGKRDMEGAPRRHRSHRSVGARMEPSSQSPPKMEPTGSQADQHFAPNPDQELSP
What are the official names of this protein?
Testis-specific protein 10-interacting protein, Tsga10-interacting protein.
Protein: CHMO_ARATH
Sequence: MMTTLTATVPEFLPPSLKSTRGYFNSHSEFGVSISKFSRRRFHNPTRVFAVSDISKLVTEFDPKIPLERASTPPSSWYTDPQFYSFELDRVFYGGWQAVGYSDQIKESRDFFTGRLGDVDFVVCRDENGKIHAFHNVCSHHASILASGNGRKSCFVCLYHGWTYSLSGSLVKATRMSGIQNFSLSEMGLKPLRVAVWGPFVLLKVTAATSRKGEVETDELVASEWLGTSVGRLSQGGVDSPLSYICRREYTIDCNWKVFCDNYLDGGYHVPYAHKGLMSGLDLETYSTTIFEKVSIQECGGGSKVGEDGFDRLGSEALYAFVYPNFMINRYGPWMDTNLVLPLGPRKCKVVFDYFLDPSLKDDEAFIKRSLEESDRVQMEDVMLCESVQRGLESQAYDKGRYALVEKPMHHFHCLLHHNLKL
What is the function of this protein?
Catalyzes the first step of the osmoprotectant glycine betaine synthesis.
What are the official names of this protein?
Choline monooxygenase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the choline monooxygenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: NSP1_ROTSP
Sequence: MATFKDACFHYRRLTALNRRLCNIGANSIWMPVPDAKIKGWCLECCQIADLTHCYGCSLPHVCKWCVQNRRCFLDNEPHLLKLQQLKHPITKDKLQCIIDLYNIIFPINDKVIRKFERMIKQRECRNQYKIEWYNHKLLPITLNAAAFKFDENNLYYVFGLYEKSVSDIYAPYRIVNFINEFDKLLLDHINFTRMSNLPIELRAITQEYFQLSRLPSSKLKQIYFSDFTKETVIFNTYTKTPGRSIYRNVTEFNWRDELELYTDLKNDKNKLIAAMMTSKYTRFYAHDNNFGRLKMTIFELGHHCQPNYVASNHPGNASDIQYCKWCNIKYFLSKIDWRIRDMYNLLMEFIKDCYKSNVNVGHCSSVENIYPLIKRLIWSLFTNHMDQTIEEVFNHMSPVSVEGTNVIMLILGLNISLYNEIKRTLNVDSIPMVLNLNEFSSIVKSISSKWYNVDELDKLPMSIKSTEELIEMKNSGTLTEEFELLISNSEDDNE
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7.  Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.
What are the official names of this protein?
Non-structural protein 1, NSP1, NCVP2, Non-structural RNA-binding protein 53, NS53.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP1 family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton.
Protein: PVK2_PERRU
Sequence: GSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, PerRu-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOA1_FRATO
Sequence: MSNNNSKLEFVPNIQLKEDLGAFSYKVQLSPVEKGMAHILGNSIRRVLLSSLSGASIIKVNIANVLHEYSTLEDVKEDVVEIVSNLKKVAIKLDTGIDRLDLELSVNKSGVVSAGDFKTTQGVEIINKDQPIATLTNQRAFSLTATVSVGRNVGILSAIPTELERVGDIAVDADFNPIKRVAFEVFDNGDSETLEVFVKTNGTIEPLAAVTKALEYFCEQISVFVSLRVPSNGKTGDVLIDSNIDPILLKPIDDLELTVRSSNCLRAENIKYLGDLVQYSESQLMKIPNLGKKSLNEIKQILIDNNLSLGVQIDNFRELVEGK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha 1, RNAP subunit alpha 1, RNA polymerase subunit alpha 1, Transcriptase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: GPH_PSESS
Sequence: LQKMGVEMALITNKPERFVAPLLDEMKLGRFFRWIIGGDTMPQKKPDPAALFFVMKMAGVPASQALFVGDSRSDVQAAKAAGVACVALSYGYNHGRPIAEENPAMVIDDLRKLIPGCLDMDAEILLPDIKRPSPRESIVVVTRKLWMKVIKALARWRWRA
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.  Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity).
What are the official names of this protein?
Probable phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: INSF3_ECOLI
Sequence: MKYVFIEKHQAEFSIKAMCRVLRVARSGWYTWCQRRTRISTRQQFRQHCDSVVLAAFTRSKQRYGAPRLTDELRAQGYPFNVKTVAASLRRQGLRAKASRKFSPVSYRAHGLPVSENLLEQDFYASGPNQKWAGDITYLRTDEGWLYLAVVIDLWSRAVIGWSMSPRMTAQLACDALQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRGSMSAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRATVFNYIECDYNRWRRHSWCGGLSPEQFENKNLA
What is the function of this protein?
Involved in the transposition of the insertion sequence IS3.
What are the official names of this protein?
Transposase InsF for insertion sequence IS3C.
What is the protein family that this protein belongs to?
Belongs to the transposase IS3/IS150/IS904 family.
Protein: SPEB_HUMAN
Sequence: MLRLLASGCARGPGPGVGARPAAGLFHPGRRQSRQASDAPRNQPPSPEFVARPVGVCSMMRLPVQTSPEGLDAAFIGVPLDTGTSNRPGARFGPRRIREESVMLGTVNPSTGALPFQSLMVADLGDVNVNLYNLQDSCRRIQEAYEKIVAAGCIPLTLGGDHTITYPILQAMAKKHGPVGLLHVDAHTDTTDKALGEKLYHGAPFRRCVDEGLLDCKRVVQIGIRGSSTTLDPYRYNRSQGFRVVLAEDCWMKSLVPLMGEVRQQMGGKPIYISFDIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVMGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV
What are the official names of this protein?
Agmatinase, mitochondrial, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: OBG_STRTD
Sequence: MSMFLDTAKISVQAGRGGDGMVAFRREKYVPNGGPWGGDGGKGGSVIFKVDEGLRTLMDFRYNRKFKAKNGEKGMTKGMHGRGAEDLIVSIPPGTTVRDAETGKVITDMVEDGQEFVVAHGGRGGRGNIRFATPRNPAPEIAENGEPGEERELQLELKILADVGLVGFPSVGKSTILSVVTAAKPKIGAYHFTTIVPNLGMVRTKSGESFAMADLPGLIEGASQGVGLGTQFLRHIERTRVILHVIDMSASEGRDPYEDYLQINKELETYNLRLMERPQIIVANKMDMPEAEENLKEFKEKLAANYDEFDELPQIFPISSLAHQGLENLLEATAELLDQTDEFLLYNEDDMEQEEVYYGFNEEERPFEISRDDDASWVLSGEKLEKLFVMTNMERDESIMKFARQLRGMGVDEALRERGAKDGDIVRIGNFEFEFVD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_AERPE
Sequence: MGRGPRYRVPLRRRREGKTNYYRRFRLVKSGKPRMAVRISNEYLWVQFLEARIEGDRVIAAAHSRELIKKFGWKGDGNNTCAAYLTGYLAGLRALEKGVREAVLDVGLHKPVKGSRVFAALKGALDAGVEIPHSEEILPGDERVRCEHIAQWAEALKEENAELYQRQFSRYLDRGLNPEELPGHVEEVKKAIEEAYKHVAEETAAEGEEVEVKA
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TXMG6_MACGS
Sequence: MRTIVFLIVSILLLSSAVLMLAEGNAASHELQEYPIEESLEEQRKCVDGSCDPYSSDAPRCCGSQICQCIFFVPCYCKYRGK
What is the function of this protein?
Induces flaccid paralysis when injected into lepidopteran larvae.  Intracranial injection into mice causes awkwardness of movement and laboured respiration until death.
What are the official names of this protein?
U7-hexatoxin-Mg1a, U7-HXTX-Mg1a, Neurotoxin magi-6.
What is the protein family that this protein belongs to?
Belongs to the rTX family.
Protein: DAPE_LARHH
Sequence: MNPTLELACELIRRNSTTPDDAGCQELMIARLERIGFTVERMRFGEVDNFWARRGSDSPTLCFAGHTDVVPTGPLTAWHSDPFEPVERDGHLFGRGAADMKASLAAFVTAIEDFVAGHPDHKGSIALLVTSDEEGVAVHGTRAVVETLAARGETFDWCIVGEPTSARQFGDTIKNGRRGSLSGKLTVKGVQGHIAYPHLARNPVHLLAPALAELAAIRWDEGNAHFPPTSWQVSNIHGGTGATNIIPGTVEVQFNFRFSTEQTADGLKNAVHSLLDRHGLDYELEWNLSGNPFLTATGDLIAAIETAVKDVTGIMPELNTSGGTSDGRFIKDVCREVVEFGPLNATIHKVNECVAVEDVPKLSEIYRRTLASLLAR
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: UBA5_DICDI
Sequence: MATPYREKIEKMSSEVIDSNPYSRLMALKKMGIVNNYENIRNLSVIIVGLGGIGSVAAEMLTRCGIGKLLLFDYDTVEIANMNRLFFRPEQSGKSKTMAAQETLSSINPDVQFESHNYNITTIDNFEHFKGRIEKGGLVEGEPVDLVLGCVDNFEARTAINQACLELGKSWMESGVSENAISGHIQLIIPGESACFQCVPPLIVASGIDERTLKREGVCAASLPTTMGIVAGMLVQNTLKYLLKFGEVSSLLGYNALLDYFPKDNMKPNPECSNSFCIIHQQKYKEFLKNNPKENLIQNNNNNNINNNEKKSTYENEWGIELIETSEDFNNNNNNNNKPSNNSFEFSYDKKPTVELNEQSTVKVNSSSNLEDLMNQLKNMK
What is the function of this protein?
E1-like enzyme which activates ufm1.
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme 5, Ubiquitin-activating enzyme 5.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
Protein: RBL_NASOF
Sequence: MSPQTETKANVGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGEETQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALAALRLEDLRIPPAYTKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHVHAGTVVGKLEGDRESTLGFVDLLRDDYVEKDRSRGIFFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAIEGNTIIREACKWSPELAAACEVWKEIRFNFPTVDTLDTQE
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y4995_PSEPK
Sequence: MKTLAPSYLKHQFLIAMPHMADPNFAQTLTYIVEHNEHGAMGLVVNRPQELSLADILEQLRPDETPPASTLQVPIYQGGPVQTDRGFVLHSSECSFQASVALEGLSLTTSQDILLAIAAGVGPKQSLITLGYAGWEAGQLEAELADNAWLNCPFDPEIVFGMASDLRLEAAAASLGINLHLLTSQAGHA
What are the official names of this protein?
UPF0301 protein PP_4995.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: PROB_PARP8
Sequence: MRSVIADSRRLVVKVGSSLVTNDGRGLDHTAIGRWAAQIAALREQGKEVVLVSSGAIAEGMQRLGWTRRPREIDELQAAAAVGQMGLAQVYESRFSEHSIRTAQILLTHADLADRERYLNARSTLLTLLRLGVVPIINENDTVVTDEIKFGDNDTLGALVANLIEGDALIILTDQQGLFTADPRKDPAATLVQQADAGTPELEAMAGGAGSSIGRGGMLTKILAAKRAAHSGANTVIASGREADILARLASGEAIGTQLIARTARMAARKQWMADHLQVRGHVVIDDGAVEKLTEGGKSLLPIGVVGVQGAFARGEVIACLNAAGREVARGLTNYSSAETKLIQRRPSGEIESVLGYMLEPELIHRDNLVLV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_BRUMB
Sequence: MLDIKWIRENPETLDKALAKRGAAPLSSELIALDEKRREHVGKVQAAQERRNAASKEIGKAMAAKDMGTAEKLKAEVGELKDFLAHAEEDERRLSKELSDALSTIPNIPLDDVPLGKDESDNVELRRIGNPHNFSFQPKEHFELGEALGYMDFERAAKLAGARFTVLKGPLARLERALGQFMLDLHTTEHGYTEVMPPLMVRDEAVYGTGQLPKFSEDLFRTTDGRWLIPTAEVPLTNLVAEEIVDMKGLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFLKVEMVSITDAESSVAEHERMTACAEEVLKRLGLPFRTVVLCTGDMGFGAQRTYDIEVWLPGQNTYREISSCSTCGDFQGRRMNARYRPEGEKSTRFVHTLNGSGAAVGRALIAVMENYQQEDGSIHIPEALQPYMGGLTRIEKAA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_MYCTO
Sequence: MRLVFAGTPEPALASLRRLIESPSHDVIAVLTRPDAASGRRGKPQPSPVAREAAERGIPVLRPSRPNSAEFVAELSDLAPECCAVVAYGALLGGPLLAVPPHGWVNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPIYGVVTEVIQPTDTAGDLLKRLAVSGAALLSTTLDGIADQRLTPRPQPADGVSVAPKITVANARVRWDLPAAVVERRIRAVTPNPGAWTLIGDLRVKLGPVHLDAAHRPSKPLPPGGIHVERTSVWIGTGSEPVRLGQIQPPGKKLMNAADWARGARLDLAARAT
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: SSB_ANAVA
Sequence: MSINIVTLVGRVGTDPDIKYFESGSVKCRLTLAVNRRSKNDKPDWFTLELWDKTAEVAGNYVRKGSLIGVKGSLKFDSWSDRQTGVNRSTPVIRVDQLELLGSKQDRDGGSSDFAPENF
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: EFG1_SYNAS
Sequence: MKNDIKKVRNIGISAHIDSGKTTLTERILFYTKRIHAMHDVKGKDGVGATMDSMELERERGITISSAATFCTWGDHEVNIIDTPGHVDFTIEVERALRVLDGAILVLCAVGGVQSQSITVDAQMKRYKVPCVAFVNKCDRSGANPARVVEQLKTRLGHNALLMQLPIGLEADFQGIVDLISMKAVYFDGAGGELLRTEAVPESLLPEAISRREELIDSVSLFSDSLTEAILEGTEISEVMIMEAVRQGTLERKITPVFIGSAYKNKGIQPLLDAVTRYLPCPADIENSALDLSREEAPVQLTSNTEDPVVALAFKLEDGIYGQLTYIRVYQGILSRGATVVNARDGKKVRIGRLVRMHADQMEDIEAIHAGYIGALFGLECQSGDTFAAQGLNLAMTSMFVPEPVISLAIVPKDKKSMVNMSKALNRFTKEDPTFRTHLDPETSETIIEGMGELHLDIYVERIRREYNAEVTTGNPRVAYRETITQKAAFNYTHRKQTGGSGQYGRVAGYIEPLSDEDFLFENKITGGAIPTQFIPACEKGFRMSMAKGPKMEFPVTGVKVVIDDGAFHAVDSSDMAFQAAARGAFREAYNKAKPVILEPIMKVVVETPNEFQGAVMGLLNQRRGMIVGTQDEGQTCVIEAQTPLAEMFGFSTVIRSATQGKAQFTMEFSAYRQVPQSIAEKITEEVAKRKKSAA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 1, EF-G 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_CUPTR
Sequence: MNIHEYQGKEILRKYNVPVPRGIPAFSVDEALKAAEQLGGPVWVVKAQIHAGGRGKGGGVKVAKSMDEVKTYASNILGMQLVTHQTGPEGKKVNRLLIEEGADIKKELYVSLVVDRVSQKIALMASSEGGMDIEEVAAHTPEKIHTLIIEPSTGLTDADADDIARKIGVPDASVAQARQALQGLYKAFYETDASLAEINPLILTGDGKVIALDAKFNFDSNALFRHPEIVAYRDLDEEDANEIEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATTEKVTEAFKLMLKNPNVQAILVNIFGGIMRCDVIAEGVISASKAVSLNVPLVVRMKGTNEELGRKMLADSGLPIISADTMEEAAQKVVAAAAGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: CLCN3_HUMAN
Sequence: MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN
What is the function of this protein?
Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons.
What are the official names of this protein?
H(+)/Cl(-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Isoform 1 is localized mainly in late endosomes. SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein. Note=Isoform 2 is mainly enriched in the Golgi (PubMed:12471024). Colocalizes with SLC9A3R1/EBP50 in membrane ruffles (PubMed:11967229).
Protein: STEEP_HUMAN
Sequence: MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDAAKHAHKFCNTEDEETMYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK
What is the function of this protein?
Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (PubMed:32690950).  Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (PubMed:32690950).
What are the official names of this protein?
STING ER exit protein, STEEP.
What is the protein family that this protein belongs to?
Belongs to the STEEP1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Detected in the nucleus and cell soma of various neuronal types.
Protein: MRK1_ENCCU
Sequence: MATLSQKKLMESVRLMEREWVKMHKALVRSRCGEVKEVRYRYVEMIGRGSFGVVVKIMDDRHNFFALKRVYQDRRYHNRELGILMEVDHPNIVRLVSYFHTDKTSSGAYLNIITDFVGMNLEEYIKANRGVETEEIRSVYRQILEGLRYLHEKNICHRDMKPSNILIDTNGLVKICDLGSAKVIKSGERNITYICSRFYRAPENLLDYKEYDFKIDIWSVGCVIAEFRHPGPIFKGDTSGSTLNRILEIVRVTSDDLIGLGCLKPDLKQGVGIRKYLEAFFSDPDLLEVLEKSLAFSPCKRSTASELLRKQFFQQAHE
What is the function of this protein?
May play a role in the initiation and completion of mitosis.
What are the official names of this protein?
Probable serine/threonine-protein kinase MRK1 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRUB_YERPA
Sequence: MGRPRRRGRDINGVLLLDKPLGLSSNDVLQKVKRLFSANRAGHTGALDPLATGMLPICLGEATKFSQFLLDSDKRYRVVARLGQRTDTSDAEGALISEREVNLTQAQIDTALESFRGESQQIPSMYSALKHQGKPLYEYARQGIEVEREARSITVYELLFIRWEGNDLELEIHCSKGTYIRTIIDDLGELLGCGAHVSYLRRLQVATYPSERMVTLEQLTAMVEAAQAEGRSPNPELDSLLLPMDSAVLNFPEVNLLPSVAAYVKQGQPVHVSGAPSEGMVRITEGKERNFIGIGTIAEDGRVAPKRLVVESVEVENLPVENKK
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: BLE_STAAU
Sequence: MLQSIPALPVGDIKKSIGFYCDKLGFTLVHHEDGFAVLMCNEVRIHLWEASDEGWRSRSNDSPVCTGAESFIAGTASCRIEVEGIDELYQHIKPLGILHPNTSLKDQWWDERDFAVIDPDNNLISFFQQIKS
What is the function of this protein?
Binding protein with a strong affinity to the bleomycin family of antibiotics, which confers resistance to these antibiotics by preventing the bleomycin-induced DNA breakage.
What are the official names of this protein?
Bleomycin resistance protein, BRP, Bleomycin-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bleomycin resistance protein family.
Protein: RN168_XENTR
Sequence: MAKVQKLPLPWSECICPICQEILLEPVTLPCKHTLCNPCFQMTVEKASLCCPFCRKRVSTWARQHSRTRTLVNKELWEVIQKQYPKQCQRRASGQESDDLSDELTSCPVPVLCKPGEIRQEYEAEVSKIEAERTAQEEAERKASEDYIQKLLAEEEAEENLHAEASQREIEEQLKRDEELARLLSGDMDLSNASCTSVSPVTSKKVVSKSSKIVKSKQRVSGDIERFLSPKPRRALAAFGINESRNSDTSGSCILLDEDEDEIPDLSPQCPSTSLIQERDVELPMPYLPNCYKLESDAASQQDSCSERNDICNGTYSCSDSIDVEVSKTMEQQRATADSQEYRMETNAMSYSTPKRKCEECYLDIEEKAGSCQSVKKKKLSLSEDSPVLSVHAGKFIELEENLYERRKQEEHDRLFALQLQRELDKELKQVNRGKGSPDEYQLRPKRGLKLQECNDSPLPHNEQTPVQDKGGNTQSGYSPDENKKPSRKKSITSSQVRQSRAVTNTERSSEGMNVLKPSNKQPTILDLFQRSAGK
What is the function of this protein?
E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage.  Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination.  Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates.  This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of tp53bp1 and brca1.  Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
What are the official names of this protein?
E3 ubiquitin-protein ligase rnf168, RING finger protein 168, RING-type E3 ubiquitin transferase rnf168.
What is the protein family that this protein belongs to?
Belongs to the RNF168 family.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage.
Protein: Y673_PEDPA
Sequence: MAVNIYDTANQMEQEIRQTSEYKSLQEAFAEVRKDEHASALYSKFQDVQSNLQQKQMNGEELTEEEIKNVHEIADQIEKVDLIKDLMDKERNMNQLFSDVSQIIVKPIQELYKN
What are the official names of this protein?
UPF0342 protein PEPE_0673.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.