PharMolix/UniProtQA huggingface dataset:
Protein: HOOK3_XENLA
Sequence: MQSLDRVDLCESLLTWIQTFHVDAPCKTVEDLTSGVAMAMVLQKIDPVYFDENWLNRIKTDVGDNWRLKISNLKKILKGILDYNHEILGHQVNDFTLPDVILIGEHSDASELGRMLQLILGCAVKCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKETPVSIGTDAYAELDRQLKKANEELNDALSAKEEIAQRCHELDMQVAGLQEEKSSLLAENQILMERMNQSDSLEDPNSPAGRRHLQLQTQLEQLQEETFRLEASKDDYRIRCEELEKEITEFRQQNEDLITLADEAQSLKDEMDVLRHSSDKVAKLESQVDSYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLEFEYKRLKEKIDSLQKEKDRLRSERDSLKETIEELRCVQAQEGQLTSAGLMPLGNQEPTDSLAAEIVTPEIKEKLIRLQHENKMLKINQEGSDNEKISLLQSLLDDANMRKNELETENRLVNQRLIEMQSQVEELQKSLQEQGAKTEDSLLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRYNNSSMKIEELQDALRKKEEDMKQMEERYKKYLEKAKSVIRTLDPKQNQGTGPEIQALKNQLQERDKMFVSLEKEFEKTKTQRDQEEKLIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATASDVIA
What is the function of this protein?
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin.  Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track).  Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor.  Component of the FTS/Hook/FHIP complex (FHF complex).  The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).  May regulate clearance of endocytosed receptors such as MSR1.  Participates in defining the architecture and localization of the Golgi complex.  FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
What are the official names of this protein?
Protein Hook homolog 3.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Golgi apparatus.
Protein: ZAPB_YERPS
Sequence: MSFEVFEKLEVKVQQAIDTITLLQMEIEELKEKNNTLTQEVQDAAGSREALVRENEQLKQEQHVWQDRLRALLGKMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: ISPD_KLEP3
Sequence: MAATFPGVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHAVAALLANACVQRVVIAVSPGDRRFSQLPLAQHPQITVVDGGAERADSVLAGLKALPEAQWVLVHDAARPCLHQDDLSRLLALSETSRVGGILAAPVRDTMKRAEPGKTAIAHTVDRNDLWHALTPQFFPRELLVDCLTRALNEGATITDEASALEYCGFHPQLVAGRADNIKVTRPEDLALAEFYLTRSRHQEKA
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: NNJA8_MAIZE
Sequence: MDDDNGLELSLGLSLGGSSGKAKARDAPLEPKAEPQVEESSSKGGLQTPDAPSGKFYQKSADNHEQNSKQRHSPVAPQFGNFWGQPGNSSGPVVDGSVEPVSHQPQLSSYQDGRMPINSGNNSEEQKPVSGNHKLPSEEMNFQKKHQTASDQPDAFSKSSDGGAKNAPISISTDDGSTGENEDVAESEAEGSNSWLVAQREDSAKGSVVNKGSDRKRSADAAADGFKGKRQPSFSGSESSSGKLTPGNLISMQASNVVALPYQVPGQVSGPPVLTNAPNFHPVCTVQLRPPTNGGLAVQTMGSASQVAFGYPAVQLPTLETGSSWAFGAPPQALSSFTAKDKADQTGTKQVDDGKKPQEAGASSSAHAEDEKKADRGLSLMGSAIRPGIAPNVKFGGSGSYPDLPWVSTIGAGPNGRTISGVTYKFGRNEVKIVCACHGTHMSPEEFMRHASADAPAQDNSATLPAFPAGNQATSAEN
What are the official names of this protein?
Ninja-family protein 8.
What is the protein family that this protein belongs to?
Belongs to the Ninja family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROC_THIDA
Sequence: MSGSTLGKLFCVTVFGESHGPAIGCVVDGCPPGMTLGESDIQHDLDRRKPGTSRHVTQRRESDTAEILSGVYEGRTTGTPIALLIRNEDQRSKDYGNIAATFRPGHADYTYTQKYGFRDPRGGGRSSARLTAPIVGAGAIAKKWLKEKYGIVIRGYMSALGPLDIPFESWDEVDNNAFFSPNAAIVPELEQYMDALRKSGDSVGARVSVVAENVPPGWGEPLYDKLDADLAHALMGLNAVKGVEIGDGMQAARQLGTEHRDEITPAGFLSNHAGGVLGGISSGQAIVAHVAIKPTSSMRLPGRSVDLDGQPIEVVTHGRHDPCVGIRATPIVEALTAIVLMDHALRHRAQCGDVASGVPIVPARLD
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RIMO_CAMJ8
Sequence: MSKLYLMSLGCNKNLVDSEIMLGRLSAYELCDEPSKADVLIVNTCGFIDSAKKESINAILDLHEQRKKDSLLVVTGCLMQRYREELMKELPEVDLFTGVGDYERIDEMILKKTNLFSNSTYLQSENSKRIITGSNSHAFIKIAEGCNQKCSFCAIPSFKGKLKSREISSIIAELKDLVARGYKDFSFIAQDTSSYLFDKGEKDGLIRLIDEVEKIKGIRAARILYLYPTSASEALIKRIIASEIFINYFDMPLQHISDNMLKIMKRGANSTRLKEMLNLMKSAPNSFLRTGFIVGHPGESEADFEELCEFVKDFGFDRISVFAYSKEEDTAAFDMEQVPFKVINKRLKIIEKIVDEVIEKSFEKEVGQKRLVVCTGKSSEGEFFIAAKDLRWDREIDGEILINESECGNLEMGQIYECEILQNLDKKLLAKALRKVDAN
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_RHIME
Sequence: MKADIHPDYHTIKVVMTDGTEYETRSTWGTEGATMNLEIDPKSHPAWTGGNQQLVDRGGRVSKFKKRFEGLGL
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: SELU_ECO24
Sequence: MQERHTEQDYRALLIADTPIIDVRAPIEFEQGAMPAAINLPLMNNDERVAVGTCYKQQGSDAALALGHKLVAGEIRQQRMYAWRAACLQNPQGILCCARGGQRSHIVQSWLHAAGIDYPLVEGGYKALRQTTIQATIELAQKPIVLIGGCTGCGKTLLVQQQPNGVDLEGLARHRGSAFGRTLQPQLSQASFENLLAAEMLKTDARQNLRLWVLEDESRMIGSNHLPECLRERMTQAAIAVVEDPFEIRLERLNEEYFLRMHHDFTHAYGDEQGWQEYCEYLHHGLSAIKRRLGLQRYNELAARLDAALTTQLATGSTDGHLAWLVPLLKEYYDPMYRYQLEKKAEKVVFRGEWAEVAEWVKAR
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: KUP_LACGA
Sequence: MNSNLRKKVTLAGLLVSIGIVYGDIGTSPLYVMKAIVNENGGIAHVSREYIVGSISLILWTITLLTTVKYVLIALKATNHGEGGIFSLYALVRKKAKWLVIPALVGGAALLADGTLTPAVTVTTAIEGLKNMKFGNDIPVPNQNSVIMITIVILLFLFSIQRMGTSIIGKTFGPIMLVWFTFLGLTGIMNLSHDWSLLEALNPLLAVKILFSPANKVGVLILGAVFLATTGAEALYSDVGHVGKGNIMGSWPYVFICLALNYLGQGVWILENPNYHAGATDFNPFFEALPSQWKFFAIILATLAAIIASQALITGSFTLVSEASGLKFLPRMKIIYPSTEQGQLFIPSINKMLCAATIGIVFLFRTSEHMEAAYGLAITVTMLMTTVLLFEYLSLRKVNLSLRLVFLLLFGAIETMFLISSLAKFLHGGYVTVIIAAFIGAIMYIWYFGNKIRDKREAENAYVRLDEFTTMLSNLSHDESIPLYATNLVYMAKVKYNKFIKRDMLYSILDKRPKRAHAYWFVTVNVTNEPFTAEYAVNTYGTKNVINVQLYLGFKQQQKVNVYLRQIVHDLIKDGTIESQPQEYTTTPGRDVGDFSFVIVNDVISPQTQLRSYEKFLVEARVWLQNLSSNPASWFGLDYADTVIERVPLILGNQRRQHITRIAPKKFEDIKKKLQAEGELKE
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 8ODP_HUMAN
Sequence: MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
What is the function of this protein?
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:22556419, PubMed:26238318, PubMed:24695224, PubMed:24695225, PubMed:28679043).  Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:10373420).  Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:10373420, PubMed:11139615).  Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004).  Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205).  Through this antimutagenic activity protects cells from oxidative stress (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:24695224, PubMed:24695225, PubMed:30304478, PubMed:32144205).
What are the official names of this protein?
Oxidized purine nucleoside triphosphate hydrolase, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, Methylated purine nucleoside triphosphate hydrolase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
What are the subcellular locations of this protein?
[Isoform p18]: Cytoplasm, cytosol. Mitochondrion matrix. Nucleus. Note=Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328). SUBCELLULAR LOCATION: [Isoform p26]: Mitochondrion matrix.
Protein: EFG_CAMC5
Sequence: MADRKTPLHMVRNIGIAAHIDAGKTTTSERILFFTGMSHKIGEVHDGAATMDWMEQEKERGITITSAATTCFWKQHQINLIDTPGHVDFTIEVERSMRVLDGAVAVFCSVGGVQPQSETVWRQANKYHVPRIVFVNKMDRIGANFYNVESQIRNRLKANPVPIQIPIGAEDDFKGVIDLVRMKAYVWEDDKKPTDYVEKEIPAELLEKAQEYRAKLIEAVSETDDSLMEKFFSGEELSEEEIKKGIKAGCLRMSIIPMLCGTAFKNKGIQPLLNAVVDYLPAPDEIEAIKGVYEDGTEVTVESTDDGEFAALAFKIMTDPFVGQLTFIRVYRGSLESGSYAYNTVQDSKERIGRLLKMHSNKREEISVLHAGEIGAVVGLKNTLTGDTLASEKDKVILEKMDFPEPVISVAVEPKTKADQEKMAIALQKLAQEDPSFRVNTDEESGQTIISGMGELHLEIIVDRMLREFKVDAEVGQPQVAYRETIRKPVEQEYKYAKQSGGRGQYGHVFLRIEPLEPASGFEFVNDIKGGVVPKEYIPAVEKGCREALQNGVLAGYPVEDVKVTLYDGSYHEVDSSEMAFKLAASMGFKEGARKANPVILEPMMKVEVETPEEYMGDVIGDLNKRRGQVSSMDERNGSKIITAFCPLAQMFGYSTDLRSGTQGRATYSMEFDHYEEVPKNVSEEIIKKRNG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRML_STAND
Sequence: MTLALALYEPDIAQNAGTLARAVACLGLELHIVEPAGFPVGDAGFRRAGMDYLDRAVIRRHASFKAFEEWRRAEGRRLVLATTRGAVAHVDFAFTETDVVLLGRESAGVPEAVHESADARIVIPLNEGARSLNVALAGAMILGEALRQTGGFARTGTG
What is the function of this protein?
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA).  Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
What are the official names of this protein?
tRNA (cytidine(34)-2'-O)-methyltransferase, tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSXT_PONAB
Sequence: MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMNMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQGQYGNYQQ
What is the function of this protein?
Appears to function synergistically with RBM14 as a transcriptional coactivator.  Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.
What are the official names of this protein?
Protein SSXT.
What is the protein family that this protein belongs to?
Belongs to the SS18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHAC1_MOUSE
Sequence: MKQESASQSTPPPSLSPAPSSAQPSWGDGDPQALWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDREGCTWGVAYQVRGEQVNEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLEAIVDAVGTLLPCSYLPEQPLALT
What is the function of this protein?
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide.  Acts specifically on glutathione, but not on other gamma-glutamyl peptides.  Glutathione depletion is an important factor for apoptosis initiation and execution.  Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity).  Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
What are the official names of this protein?
Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, Blocks Notch protein, Botch, Cation transport regulator-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network.
Protein: RL27_STAES
Sequence: MLKLNLQFFASKKGVSSTKNGRDSESKRLGAKRADGQYVSGGSILYRQRGTKIYPGENVGRGGDDTLFAKIDGVVKFERKGRDKKQVSVYAVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: GREA_BACAN
Sequence: MATEKTYPMTQEGKQKLENELEDLKTVKRKEVVERIKIARSFGDLSENSEYDAAKDEQAFVEGRITQLENMIRNAVIITDNGEESTVVTLGKTVTFKELPNGDEEAYTIVGSAEADPFEGRISNDSPIAKSLLGKQIGEKVAIQTPGGEMQVEIISVK
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: YR624_MIMIV
Sequence: MQSLKKSVDDTGNTNNIVSSGLPLDKSLEKIESSKYVVLGNVDAGKSSFVGVMKKCILDDGNGYARSLIAKTKHEKETGRTSTQSSHYIVNNGEITTLIDLCGHEKYLKTTMFGITGLFCDYGLVIVSANSTLEARGVTMEHISLLNANRIPFIVIVTKIDICPENILISLKKKFDYIASKSKKKILYFEDSEEEFNGSYLKESHQILIDSFQNRKTFVMPVIMVSNKTGHNINFVRELLTSIKSRSYLERKGLIKPMNKLSDKYPMIMYIDSSFSVPGIGIVLSGTVKYGSIKVGQKLFLGPVNNTYINITVKSIHNCISENVDTLEKNESGSIGIRLDTKGSFSKEMFTKGQIVTNDFDFAMKNTCYSFNCRISVFNHPTTIMNGYQTVIHCKTIRQPGRFKLNDNQVLRANSTTSLDIKFTRRPEFILPKSIFMFRDGRTKGMGIIEGGIPFIEDTPDIIKKQKKSVKKIPEKKIGK
What are the official names of this protein?
Putative GTP-binding protein R624.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.
Protein: SSPH2_BACCN
Sequence: MNVQRAKEISESAEQANVSFQGMPVMIQHVDENSETARIYDAANPERELTVPVKSLEER
What are the official names of this protein?
Small, acid-soluble spore protein H 2, SASP H 2.
What is the protein family that this protein belongs to?
Belongs to the SspH family.
What are the subcellular locations of this protein?
Spore core.
Protein: CH10_CALS4
Sequence: MRLKPLGDRVVVKVIQSEEVTKGGVILPGTAKEKPQQGEVVAVGPGQYIDGKRVEPEVKVGDRVIFSKYAGTEVKLDGEEYLLLRESDILAIIE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYC2_DICDI
Sequence: MLKSLSKLTPSIRGVVSINRSFCTKKFLPTNRSVSESDPEIYDLMMKEKQRQFTGLELIASENFTSRAVMESIGSCFTNKYAEGLPGARYYGGNEVVDQLENLCIKRALETFNLNPEEWGVNVQPYSGSTANFAAFTGLLKPHDRIMGLDLPSGGHLTHGYQTDKKKISATSIFFESMPYQVNETGYVDYNKMEANAALFRPKLLIAGASAYPREWDYERMRKIADKHGAYLLCDMAHISGMVAGKQAISPFLFCDVVTTTTHKTLRGPRAGLIFFRKTKRRDAKGNIIDDDLENRINFAVFPSCQGGPHENTIAGIAVALKEASSPDFQEYTKQVRRNSQTMGEELKKRGYSLVTEGTDNHLVLWDLRPQGITGSKIEKACDEAHITVNKNAVYGDTNAIAPGGVRLGAPALTSRGLKEQDFVKVVDFLDRVVKISLDIQSKVGKKMPDFQRAIADNQDLKQIRQEVKEFSTKFGMPGEL
What is the function of this protein?
Interconversion of serine and glycine.
What are the official names of this protein?
Serine hydroxymethyltransferase 2, SHMT 2, Glycine hydroxymethyltransferase 2, Serine methylase 2.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
Protein: FLR_MEGG1
Sequence: MKRSLGAKPLLFPTPVLVVGTYDDQGRPNAMTAAWGGICCSKPPCVTVSLRKATYTYASLMARKAYTLHVTDEPHLTASDFLGMASGRDGDKLGTLGLTTVRSELVDAPIIQEYPLVLECKIVHVHDLGLHTMFVGEVQDIKADARVLDEKGHLLLDALKPLGFMPEVRTYHGMGPALGRAFDAGKLHMPKKAE
What is the function of this protein?
Participates in the reduction of hydrogensulfite from hydrogen.
What are the official names of this protein?
Flavoredoxin.
What is the protein family that this protein belongs to?
Belongs to the flavoredoxin family.
Protein: NU2M_EQUAS
Sequence: MNPLILTIILMTVFLGTMIVMASSHWLMIWIGFEMNLLAIIPILMKKYNPRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWTITKVFNPTASIIMTLALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMAAILVYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKAPLITTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFETKQITLLPPLIIASSLLLPLTPMLSILD
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HEM3_STAAN
Sequence: MRKLVVGSRRSKLALTQSQQFINKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSLKDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTEDYDAIILAAAGLRRMGWSDDIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGSCQVPIAGYATISDQKEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEIIKRLNEQH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PWP2A_MOUSE
Sequence: MAAVAAEAAATAASPGEGGAGEAEPELEPIPGSEAGTPLPVTATEAAVPDGEADGRQSAPQADEQPLPPPPPPPPPGELADSSEAEEAKPPEPAAVPVSPPEQPPAAPEQPEDAPRPPPAPALVPPAGGDSAVSHLIPGSEVRVTLDHIIEDALVVSFRLGEKLFSGVLMDLSKRFGPHGIPVTVFPKREYKDKPDAMQLQSTTFQEGIEVKQEVNGAVPDDLSPVPPPERLWASKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRKMYREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGSSDSSRYEDKKRRNDSVATVNKKLKTDHKVDGKNQNESQRRNTVVRVSSIAHSRGRVVKVSAQANTSKAQLNTKKVLQSKNMDHAKAREVLKIAKEKAQKKQSETSTSKTAHAKVHFTRRYQSPSSGSLPPRVRLKPQRYRNEENDSSLKTGLEKIRSGKLAPKPQSRCTSTRSAGEAPSEKPSPSEGPEESAGEVQDTSRVRVPGEQEELRMLGKKGSKSSISVYLTLNQETSDSSSASVCSIDSMDDLKSSNSECSSSESFVFPPGCMHAPSASSTSTSFSSKEENSLRNSLKMKIFSKNVSKCITPDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDNGLLARQEARISWFASPTTSSLALSQLSPFLENFQLRFNKKRKGLYRRAITEAAKAAKQLTPEVRALLTQFET
What is the function of this protein?
Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A. Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:33235983).  Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A. Z (By similarity).  Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (PubMed:30228260, PubMed:33235983).  Essential for proper mitosis progression (By similarity).
What are the official names of this protein?
PWWP domain-containing protein 2A.
What are the subcellular locations of this protein?
Nucleus.
Protein: MECA_STACT
Sequence: MRIERVDDTTVKLFITYGDIESRGFKREDLWTNRQRGEEFFWSMMEEINEEEDFVVEGPLWIQVHAFEKGVEVVISKSKNEEMMNMADDNMNNEFDRQLNELLEQSFEDENEESVQGNQQQRRSHASDHSKRARHTNGRLVIVKFEDLESVIDYAHHSNQPTDDFEDLLYMLNNEYYYAIHFDDNVGEEVINDFYSQLLEFTQPSDRSEMYLNDYAKIIMSHNVTAQVRRFFTDTEEI
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.