PharMolix/UniProtQA huggingface dataset:
Protein: CRYAA_TAMME
Sequence: MDVTIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTALDSGISEVRSDRDRFVILLDVKHFSPEDLTVKVLDDFVEIHGKHNERQDDHGYISREFHRRYRLPTAVDQSALSCSLSADGMLTFSGPKLVDPSHGERTIPVSREEKPSSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.  Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: EGY3_ORYSI
Sequence: MSSSSLVTSLLFSSSSSSNTATSTSSRRSFSLFSKNQYCKPSPLRRSSSLLLVRCSLQQQQEEKAAPAAESHHAGGGQDDAATASHHAVEGENGVADADGGGVKKSKEELEEEEQQEVDWRSDEEFKRFMGNPSIEGAIKLEKKRADRKLRELDREPDANPLAGLLRGLARGQLAREKERLELAENTFKALDLNKLKSCFGYDTFFAVDVRRFGDGGIFIGNLRKPVEEVRPKLEKKIAEAAGTDVTLWFMEEKNDDITKQVCMVQPKAEIDLQLEITKLSTPWGYLSAVALAVTTFGTIAIMSGFFLKPGATFDDYVSDVLPLFAGFLSILGVSEIATRLTAARYGVKLSPSFLVPSNWTGCLGVMNNYESLLPNKKALFDIPVARAASAYLTSVALAVSAFVSDGSLNGGKNALFVRPEFFYNNPLLSFVQAVIGPYADELGNVLPNAVEGVGVPVDPLAFAGLLGIVVTSLNLLPCGRLEGGRIAQALFGRGAAAVLSFATSVALGAGAIIGGSVLCLAWGLFATFVRGGEEIPAQDEITPLGSERYAWGLVLAVVCLLTLFPNGGGTYSSDFLGAPFFRGGI
What is the function of this protein?
Probable membrane-associated metalloprotease that may be involved in chloroplast development.
What are the official names of this protein?
Probable zinc metalloprotease EGY3, chloroplastic, Protein ETHYLENE-DEPENDENT GRAVITROPISM-DEFICIENT AND YELLOW-GREEN 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: FUMC_PSEPK
Sequence: MSRIETDSLGPVEVPEDAYWGAQTQRSLINFAIGKERMPLAVLHALALIKKAAARVNDRNGDLPADIARLIEQAADEVLDGQHDDQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGKGRGGKAPVHPNDHVNRSQSSNDCFPTAMHIAAAQAVHEKLLPAVTELSSGLAELSMRHHKLVKTGRTHMMDATPITFGQEVSAFVAQLDYAQRAIRATLPAVCELAQGGTAVGTGLNAPQGFAEAIAAELAALSGLPFITAPNKFAALAGHEPLTSLAGALKTLAVALMKIANDLRLLGSGPRAGLAEVRLPANEPGSSIMPGKVNPTQCEALSMLACQVLGNDAAIGFAASQGHLQLNVFKPVIIHNLLQSIELLADGCRNFQQHCVAGIEPDAEQMAAHLERGLMLVTALNPHIGYDKAAEIAKKAYSEGTTLREAALALKYLTNEQFDQWVRPENMLAPGGKG
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TKT_PANTR
Sequence: MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAKTFKGRGITGVEGKESWHGKPFPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVILKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELLKMFGIDKDAIAQAVRGLITKA
What is the function of this protein?
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
What are the official names of this protein?
Transketolase, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: CH10_STRLI
Sequence: MTTTSSKVAIKPLEDRIVVQPLDAEQTTASGLVIPDTAKEKPQEGVVLAVGPGRFEDGNRLPLDVSVGDVVLYSKYGGTEVKYNGEEYLVLSARDVLAIVEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOS2_MOUSE
Sequence: MACPWKFLFKVKSYQSDLKEEKDINNNVKKTPCAVLSPTIQDDPKSHQNGSPQLLTGTAQNVPESLDKLHVTSTRPQYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQNEKLRPRRREIRFRVLVKVVFFASMLMRKVMASRVRATVLFATETGKSEALARDLATLFSYAFNTKVVCMDQYKASTLEEEQLLLVVTSTFGNGDCPSNGQTLKKSLFMLRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFDVRSKHHIQIPKRFTSNATWEPQQYRLIQSPEPLDLNRALSSIHAKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERVVDCPTPHQTVCLEVLDESGSYWVKDKRLPPCSLSQALTYFLDITTPPTQLQLHKLARFATDETDRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLHVPAAFLLSQLPILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWIRNLKPQDPVPCFVRSVSGFQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQEEMQEMVRKRVLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLHGEQGHLYICGDVRMARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGSALEEPKATRL
What is the function of this protein?
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7503239).  In macrophages, NO mediates tumoricidal and bactericidal actions.  Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (PubMed:16373578).  As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (By similarity).  Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (By similarity).
What are the official names of this protein?
Nitric oxide synthase, inducible, Inducible NO synthase, Inducible NOS, iNOS, Macrophage NOS, MAC-NOS, NOS type II, Peptidyl-cysteine S-nitrosylase NOS2.
What is the protein family that this protein belongs to?
Belongs to the NOS family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization.
Protein: ACYP_GEOTN
Sequence: MKRVHVIVEGRVQGVGFRYFVQHEALKRQLTGWVKNNDDGTVEMEAQGHESAVQLFLDTIEAGTMFAKVSRMHIEQRDVRPDEKQFRIMYGGGL
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: PDXH_BRASO
Sequence: MTDPTSIKHQTTLTSGTSADFTQAGEPFALFAEWFAEASKSEPNDPNAMALSTVDADGLPDVRMVLMKGYDADGFVFYSHKASQKGQELAANPKAALLFHWKSLRRQVRIRGLVTPVTDAEADAYFATRPKQAQLGAWASKQSQPLESRFAFEQAIAKVATQYIIGEVPRPPGWSGWRITPVRMEFWHDRPFRLHDRIEFRREAAGQPWTKVRMYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: LEXA_GEOUR
Sequence: MEKLTPRQQMVLAFISAHLESHGYPPTLREIGGHLGINGTLGVMKHLDALERKGFITRNAGSSRGIVLVGAVAATSIPIVGVVRAGALQPAIEDIEGYFAVDRALVKGADCFFLRVKGDSMIEAGIRSGDLALVRPQATADNGDIVVARINDEATLKRFFREKDRIRLQPENSAMEPIIVKAKAGEVNIIGKVTGIFRSLE
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: MUKB_SHIB3
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAIERQEENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADSAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQLVVAINGPLARNEAWDVARELLREGVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPVWLAAQNSLNQLSEQCGEEFTSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLDGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVVFESDPEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRERLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAAYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLVISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFGQVNSVRLNVNVRETHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGTDEAPSQAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: ELOA1_SCHPO
Sequence: MYSLKDLCIQVAQKHVHDIDDIGDCPFELVKPILEKARPEHLIDLEEKSPHLKVDTQPLWKDHVLRDFGLELQKRTILNNIDDWRGLYGKLKKKRNAHYNVASAKLRSAYTKLEQSKQNKRIVPLEREPRAARPPKRPRPMSNYCPKSSLMARAKSDFLKKASATRHIVSATSSSRSFPQLHPLGRSSSNATNTSTKRPLTSNTYPSIPLPPKSFTSQNFKSFNAVKTQPSSSSSPSISRPTSFPMSFFPNPSRFSSQVPKRI
What is the function of this protein?
As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit rpb1 to trigger its proteolysis; plays a role in global genomic repair.
What are the official names of this protein?
Elongin-A, Protein pof4.
What is the protein family that this protein belongs to?
Belongs to the ELA1 family.
Protein: INO1_BRANA
Sequence: MFIESFKVESPNVKYTENEIHSVYDYETTEVVHENVNGAYQWIVKPKVVKYDFKTDTRVPKLGVMLVGWGGNNGSTLTAGVIANKEGISWATKDKVQQANYFGSLTQASSIRVGSFNGEEMYAPFKSLVPMVNPDDVVFGGWDISDMNLADAMGRAKVLDIDLQKQLRPYMENIVPLPGIYDPDFIAANQGSRANNVIKGTKKEQVDQIIKDMREFKEKNKVDKVVVLWTANTERYSNVIVGLNDTMENLMNSVDRDESEISPSTLYAIACVLEGIPFINGSPQNTFVPGLIDLAIKNNVLIGGDDFKSGQTKMKSVLVDFLVGAGIKPTSIVSYNHLGNNDGMNLSAPQTFRSKEISKSNVVDDMVASNGILFEPGEHPDHVVVIKYVPYVADSKRAMDEYTSEIFMGGKNTIVMHNTCEDSLLAAPIILDLVLLAEISTRIQFKSEKEGKFHSFHPVATKLSYLTKAPLVPPGTPVVNALSKQRAMLENILRACVGLAPENNMILEYK
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner.
What are the official names of this protein?
Inositol-3-phosphate synthase, MIP synthase, Myo-inositol 1-phosphate synthase, IPS, MI-1-P synthase.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHITL_CAEEL
Sequence: MGIKTLIWLSILVVGIYCEISDEDAPVHYCFVNPPPKTRLSPNLLQNITTCTHLVYGSIPIDRDTGYPQYSVSDVESGYDIDNIRTFMRLRKYHPNAKLLMGVVRTKPFEDAATSVKVANGLRSHVKSKRFDGLFVTFNGIHLEYRASTSFLETISKDKKMSLTFGVTGRRVFAFDALRRLQEINDLVEYIYLDMGELPSNEELARVTHINPLFYNGSIPFEETIQGTVEELSKEGILPSRIVVGLTAGGWKFEIKETQDPLKISHGQYAENNGKRVSYQDACRARGAVIYDWQTMNEITVYRQTWMSVNLPTIKAMGEKMKWILGQKFAGIGISHALFDDPRGDCGTDPLPAHRLVMELIRNTIPANPAKCTRLCYLDPEEVEETFPIDNLKSDYCSHIVVPYFALDLSDKMIEEDKAEDLVKKIDDWRSKIVEVAPRLILSVGSKQASTIWQFLLGNDFHRKELAEGLVKAINSTNADGLEISWTSQPMVSDFDKKNLKSFINDIVAADTAKMVEIVVATSQQSAYSDFYDYEHLNKTASLIVLHSHRLHSDSLPFTGHPSPLRATSSMTNQKMSWESLLSHWVEKRVLPSKLVLSLSASTLSMQSLADVRSSAATPFGQSAFVSMLRSKKGDIHSQQEICESLKSGTGVTHWVDGAEVPYLRRYDQMVAYENTRSAHIKAVWASMEGVGGLALHNMHQDDPSAVCDNRTAFPILNALSRAQVCQTCLKQHDFKKCEQHDFVVSCNFELKRSTPVFKTDIVPYERCTEVVVEQATLTLGGNVNFNDVQQEQVVKNLTSLRSKMVKCGMVLSLSCGDSEKYLNSILGDNMTFAIGNVMNIMEKYKFSGVQLDCEKVIRRGNHIYFNTFVKKLAQKFESGKASNGCNRTLSARFSHYTQKPSTYYSVSLLNRLSHIALRMTDKHSVDLPFFFNHTKPEFPSTEKFVNIWKNVGLKPDKLVLELSPFGWQTGKKVGEKKKMTQGVNCVTAGNRAVYEHDYETLTGMTKHENGTINMPMIEDFRYKIGYIQREQLGGIALNVNGDDYTGICGRGSFPILKSVYSSHKCR
What is the function of this protein?
Putative chitinase.
What are the official names of this protein?
Chitinase-like protein C25A8.4.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GATB_STRP3
Sequence: MNFETIIGLEVHVELNTNSKIFSPSSAHFGEDPNANTNVIDWSFPGVLPVMNKGVIDAGIKAALALNMDIHKEMHFDRKNYFYPDNPKAYQISQFDEPIGYNGWIEIKLEDGSTKKIRIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMRSPEEAYAYLTALKEIIQYTGISDVKMEEGSMRVDANISLRPYGQEQFGTKTELKNLNSFSNVRKGLEFEVERQAKLLRSGGAIRQETRRYDEANKGTILMRVKEGAADYRYFPEPDLPLYEIDDAWIDEMRAQLPQFPAQRRAKYEEELGLSAYDASQLTATKALSDFFETAVSLGGDAKQVSNWLQGEVAQFLNAEGKTIEEIALTPENLVEMIAIIADGTISSKMAKKVFVHLAKNGGSARAYVEKAGLVQISDPAVLVPIIHQVFADNEAAVADFKSGKRNADKAFTGFLMKATKGQANPQVAQQLLAQELQKLRD
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: YL103_MIMIV
Sequence: MPKYVRRKEVLEVLKVHYQTLYRMEEKGLIEVKRTNGGHRLYNLEKYLRDNGLDNKEKKGICYCRVSSKKQIKDLNRQVEYMEKNYPEYEIIKDIGSGINMERKGLLQLIQMAIDGEISEVVVTYKDRLARFGFELIEWIIKTYSNGQIKIIHKREEETPEEEITRDILQIMNVYVAKINGKKSGKLKAKK
What is the function of this protein?
Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products.
What are the official names of this protein?
Putative resolvase L103.
What is the protein family that this protein belongs to?
Belongs to the site-specific recombinase resolvase family.
Protein: CLPB_BORPE
Sequence: MRFDKLTTKFQQALADAQSLAARNDHPYIEPVHVLAALLGDPDSGAASLLARAGVAVNRVQPAIDSALKGLPQVQGDDNVQVGRELQSVLVRTDKEAARRGDTYIASELFLLALADDKGDAGRILREAGLQKKALEAAIDAVRGGENVSGAEGESNREALSKYTLDLTERARQGKLDPVIGRDDEIRRTIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNDEVPETLRGKRVLSLDLAALLAGAKFRGEFEERLKAVLKELAQDDGQNIVFIDELHTMAGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYRKYIEKDAALERRFQKVLVGEPDVESTIAILRGLQERYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAGARIRMEIDSKPEVMDRLDRRIIQLKIEREAVKKETDDASMRRLAVIEEELEKLQREYNDYEEIWKAEKAAVQGTQAIKEEIDRVRAEMAELQRKGQFDKLAELQYGKLPELEARLKAADSAEREAGESDSGKPRLLRTQVGAEEIAEVVSRATGIPVAKMMQGERDKLLRMEDFLHKRVVGQDEAVRLVSDAIRRSRAGLADPSRPYGSFLFLGPTGVGKTELTRALADFLFDSEEHMIRIDMSEFMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTVIVMTSNLGSQHIQSMAGKPYEVIKEVVWDELKHTFRPEFLNRIDEVVVFHGLEAQHIESIARIQLKRLGERLEKQEMRLDVSDAALAEIARSGFDPVFGARPLKRAIQQQIENPVAKLILEGVFGPRDVVPVDWQDGKFVFTRTLQ
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPA_AMOLO
Sequence: MFTLKKSLLLLFFLGTINLSLCEQERNAEEERRDEPDERNAEVEKRFLPIVGKLLSGLSGLLGK
What is the function of this protein?
Antimicrobial peptide with activity against Gram-positive and Gram-negative bacteria and against fungi (PubMed:17000029).  Has been tested against S. aureus (MIC=2. 0 ug/mL), E. coli (MIC=3. 0 ug/mL), B. dysenteriae (MIC=1. 5 ug/mL), and C. albicans (MIC=6. 5 ug/mL) (PubMed:17000029).  Can regulate or mediate antimicrobial response by stimulating mast cell degranulation (PubMed:17000029).  Induces histamine release (PubMed:17000029).  Shows cytotoxicity toward solid tumor cell line HepG2 (PubMed:17000029).  Also shows a weak hemolytic activity (PubMed:17000029).
What are the official names of this protein?
Temporin-ALa, Amolopin-2a.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FEN1_PHYIT
Sequence: MGIKGLMKLLQEEAPSCIKEVEKMSALAGHAVAIDASMALYQFLIAIRSADGGGPSQALTNADGEVTSHLQGMFSRTIRMMENGLKPVYVFDGKPPVMKSGELAKRSDRRQEAQKALEEATEKGNAEDIDRFNKRLVRATPQHNEDCKELLRLMGVPHITAPCEAEASCAALAKGGRVYAAGTEDMDALTFGVPVLYRRLTVSPAKKIPILEIRLERALQELEMTHEQFVDLCILCGCDYCDSIRGVGPKKAYAGIKEHKSIENFLEVLQKNKSKGVVIPDEWLGENPIYKNAREMFIKPEVVDAKETEIKWRDPQETELVDFLVKKHGFQEDRVLSAITRLKKSKSTQSQKRLDSFFTVMPSANGAKKRKAPAAKGGKKAATAKKGKK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: RK22_CHLSC
Sequence: MKKKRFNSDIEVQAFARHICMSAHKMRRVIDQIRGRSYEQTLMILELMPYRASYPIFRLIYSAAANASKTMGSKEADSLISKAEVNEGTFIKKLKPRARGRSYPIKKPTCHIIIVLKDKSKKPKSFLERKYGFVDKYMIGK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL14_HISS2
Sequence: MIQEQTMLDVADNSGARSVMCIKVLGGSHRRYAAIGDIIKVTVKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGAVIRFDGNACVILNNNTEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RL27_ECO55
Sequence: MAHKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: HEM1_XANCP
Sequence: MTLWVLGLNHQTAPVDLRERAAFAGDALPRALDSLRILPQVREAALLSTCNRTELYAMADDPQTLVAWLDMHAPGLSGYLYQHRDAEAVRHLFRVATGLDSMVLGEPQILGQVKDAWAVARAHGALGSGLDRLFQQTFSVAKRARTDTRVGANPVSVASTAVRLAQESFARLNESTVLLVGAGETIELAAKHLSEGRVRRLLIANRTLAHAQTLATQHGGVALPLTELDRHLAEADVVFSATAAREPVVTRVQVEQALRTRKRKPMLLFDLAVPRDIEASVAELSDAYLYTVDDLERAVEDNRRSRREAADQAEAIIDLQVARYVETLQANERQAPLKRLRAFGDSTRDELLAKARQQLSNGKPADEVLEQLAHALTNRLLHPPTAALRDAALNNDLDLTSAADRLFPEKPGYRHPPVATPIVRTDDANPAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RRF_MYCMS
Sequence: MTDLILKNAELQMKETIDAYVIHLRQIRTGKASGAILDKVMVNYYGSLMPLNQISQITTPEPNLIIIKPYDRNVITEAVGAIHKADLGLNPVSDATLIRIPIAPLTEDVRKNLVKKVHKELEGYKIRIRNIRRDAIDEIKKIENISKDLISDNEDQIQQITDKFIKQLDDLTKEKEKELMTI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.