Protein: PADA_STRGC
Sequence: MKDFLKKVLILFTVLLMSMPSSVLNLGTSVVRADDPLNIETRRIDEHTTITQNGCYRKIEKTDATDWTVPRKPIDLVILQDASGSFRTTIPSVKNALKRLTTYVSPEQYDENDPHLVKTDDPRTTDRVFVASYQGLDQVRYFENNDFSGNPANVYTDANSTGKNYTYGNSGLTSDQNKVHNFIDNIAVDGGTPTVPAIDDTIAQYNRVKGNMENGRKTVFLLVTDGVANGYRLPGTNTVVMDKSWTRTDAIQKAWRVDSYPEAAQDIIGRANELKAAGNQLKAAVGSEGSVVVGFWERVDNFTEKYYQYGPAYLNGFGNTINIGDNRSVQAIFHDALQSMASPDKVVNGKNVSFYVNEQNNIDVFSQKILESVAAALVKDDITGEFDITEGYKVDAIRINGKKIVPKVTDPSKEIRGTITQTGNKVKISVPDSVFNPGKNSFDYDLSKEARAPETDEDSEVDPPENYVPEKEEITVPELTGKFKAGDFETRQIGGRNQTVEVQKLEYCYPSATKTVKDADASNDIGVIPDPLELTKKPSYSAQLSKKDEEFTYTVDYNFNNVPYEFEKNVMLTDPIDYRLEVVSHSAQGPDGQSWPTRVVTQQDAGGNSQSVVVADVPPQGKDYNYLIMKKAKLKMTVRLKEEYRKNQASKAYLAILQNNNGYGLVNQGNIMWNGEDDSPNQDAHAKTKDKASTIRRSNPIYVKPPLDTEVDKKVNEKEHEGLQADGEEFEYKVTAPWPGIADKFTLTDTVVDELEIVPNSAKVTVAGKSYNALTKAISINGQTIDITLDKAQLTSLNRLISRRGGSEVQEIELIFKAKIRPGADLSKYKKNGAVNIPNTADVILNDKKKTSKEVTVTPPKPKEPTVSKKINNTLDSLVTFDGQPYTYNITTAVPSDVAGYKKFVISDKLDADLEFDGQASISGPLADVFEIQTNGQTVTATVKEGKFKELAKYSFVELTIPAKVKAGVTGKTIENKAKISFTNENNVAKEVESNPVTVTPPPVTKKINENLDHLDIATGQPYKYNVKTTLPSDITSYKEFVITDTLEDELSVINEGTDKPVISGPAAEFFDVTVSGQKVTATMKNFAGASALAGQEIELVIPAKINDGVTRSNIPNKATFSFKDKNDHKGEKETIPVTVTPPTEPNVSKKINGDQDNATIAAETDFTYNIKTTLPNDIDTYKSFAITDTLDENLGVVNPEPSISEEAKKFFDITVSGNTVTATMKDFAKASALANKEIELVIHAKVKKESVLPEIPNTAKITYTNKNNESKEKETEPVKVTPPPITKKVNGKDQEDLASLTSTFKYTVDSKVPIVADKFVLSDTLEEVLTFDGDATVTIDGQTVTDVTVAKKDQKLTVTFDKDQVKKYAGKAVQVAFDAKIKSGYTVDQLVAKYPNGDKAAIPNKASFVVNDNPETEKFSNPVTVTPPPPNTPEIEKKVNGADSYNLQTRLEEFTYSLNTAMPTNATEFTVTDELKSVLEFAGKKGDVQVKIDGKAANDQATISTDKNTLTVAFAEKAVKANAGKSIEVTFKAKIREGANLLDYLVPGQGIRIPNKASYDIDHNPKFHKDSNEVPVTPPSPEQPPIEKDVNDKAEATLEARDEEFTYHVKTKIPYEATAFNITDTLKEVLDFSGEKGQAEATVDGKKLSDDHIAINGQTITVTLNQEELKANADKEIKLTFKAKIRPNANLAAYVVGDKVVINNQASYNVDLPDNPGVHKDSNIVPVTPPSPEKPEIEKTVNDAKEATLANRDEIFTYKVKTKVPFDATAFSIDDTIKDVLEFADAGSATLNGEALEADRISIADQKITLTLTEDQVKNNGGKEVVLTFKAKIRQGANLSGYIEKGKTVINNQASYNAAFPNDPNFHKDSNIVPVTPPNPENPPIEKKVNEAESANLGARDEEFTYTIDTTVPLDVTGFAVYDTIEKVLEFSGENGQASATVDGQPLDASHITIKGQKITVKLTEDEAKALGGKAVHVSFKAKIKAGANLSDYIEKDGTTRIYNTAKYNFNNDPGTEQSSKPVPVIPPTPTEPELKKEVNGKEAETLANRDDVFTYTVKTTVPQDATAFSISDSLVPVLEFAGEDAEASLTLNGEKLDAKQIKLKDQTISAELTEAQVKANGGKEVVLNFKAKIREGANLADYIEADGVTRVPNKASYVANFPHRPKVEKDSNIVPVTPPSPENPPVEKKVNNKPSATLDSRDEEFTYTIDTKVPVDATGFKITDELKDVLEFSGKKGQAEVTVDGDKDVIEDSQITVDKQVLTVTLTKDQVKKYGNKAVHVSFKAKIRKNVSLAGYIEADGVTRIPNIAKYIINDDPKTEKSTEPVPVIPPSPEEPGIKKEVNGQPEATLKERYEEFTYKVTTSVPQDATAFSVSDTLVPVLEFSGEKGQATATLDGQEIDANRINVADQTISMALTEDEVKANGGKEVTLTFKAKIREGANLSAYIEKGKTSIPNTASYTAGFPNRPEIHKDSNRVPVTPPTPEEPEIKKDVNGKEEETLANRNDEFTYHINTKVPFDATAFSINDELKDVLEFADGTGRATASLNGQALDADRISINGQTITVNLTEEQVKNNGGKDVNLTFTAKIRQGVNLSGYIKDGKTSIPNKASYRVDFPNNPGVTKDSNEVPVTPPSPENPPIEKKVNEAESANLGARDEEFTYTIDTTVPLDVTGFAVYDTIEKVLEFSGENGQASATVDGQPLDASHITIKGQKITVKLTEDEAKALGGKAVHVSFKAKIKAGANLSDYIEKDGTTRIYNTAKYNFNNDPGTEQSSKPVPVIPPTPTEPELKKEVNGKEAETLANRDDVFTYTVKTTVPQDATAFSISDKLEDVLEFAGESSATLAGEDLKADQITTDGQIIKLTLTEDQVKANGGKEVVLNFKAKIREGANLSAYMKADKAEVPNKASYTVGFPNKPAVTKDSNEVPVTPPSPEQPPIEKDVNSKPSETIADRTEEFTYNIHTTMPQDATGFTVTDELKDVLEFAGDVQVTLGGKKADAAVAKNGQTLEVTFPEETVKANGGKKVQVTFKAKIKADADLTPYETANSYSVPNTASYLINNNPTSKKETKPVTVEVPKQPGPEVTKKINRTLDHLDVDRDVPYMYNVNTQIPKDIRLYKEFTVTDTLEPVLEITGTPVAYVDGYATDAVETKVEGNTVTVTVKDFARISGYKEIQLYIPAKLKADSDLSAYENQTVPNKATIAFKDSNGKNGTKESNPVTVRPRDPEKPEEPKPNEPAKTVGPADGSNPSTAYRLKELKEGFRFDVTAKVPTDPVDESGNPIKDAQGRDVKTELNSFTVTDELEKVLKVDRVAVKVEENKVAEAIAKITAKIEKAESDLKELEGKETNGTFAKKLAEAEKKVEELTAQLAAAKEKAAAAPATPAPASDSDAGNATATPAPADNNAEVAALEESLKAAQAELEQLKADGAKAGNLATPEEQKVEQDKLNKNLEQLKESKEKLEKALEAFTTVNDKGEITDEALAKIAKVTVEGQKVTVEVTDKAVLEALKGSTFRVIIYSSIKDGADLSSYLNKENNETKIPNKATVTFNDKPKVTNTVNVYPPEPTTPPQTPPHTPPTTPGTPPPTTPDTPPAPKGDLPPAPTPEPEKPKNILPKTGTSATMVNEVIIGMILVLMGLLLRRKPKH
What is the function of this protein?
A cell wall protein involved with Hsa in host cell interactions required for colonization and pathogenesis (PubMed:19884334, PubMed:21071690, PubMed:24136582, PubMed:27616700).  Involved in recognition of platelets.  Interacts with human platelet integrin receptor GPIIbIIIa (a complex of ITGA2B and ITGB3) (PubMed:19884334).  Involved in platelet spreading, presumably by activation of outside-in signaling leading to platelet activation and then spreading.  Spreading also involves GPIIbIIIa (PubMed:21071690).  Binding to platelets under static conditions causes platelet dense granules to secrete ADP (similar to release induced by fibrinogen binding), has no effect on platelet alpha granule release.  The N-terminal 656 aa residue fragment (called F2) also binds platelets, causes dense granule secretion and allows platelet spreading (PubMed:24136582).  Acts in concert with Hsa to promote binding to human fibronectin (FN1) and vitronectin (VTN), and biofilm formation.  F2 bind activated platelets more strongly than unactivated platelets.  Binding to both FN1 and VTN is mediated at least in part by their glycosylation (PubMed:27616700).
What are the official names of this protein?
Platelet adherence protein A, Adhesin PadA.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor.