PharMolix/UniProtQA huggingface dataset:
Protein: YIF1B_RAT
Sequence: MHATGLAAPAGTPRLRKWPSKRRVPVSQPGMADPHQFFDDTSSAPSRGYGGQPSPGSLGYPTSSSEAAFLAAPMSNMAMAYGSSLAAQGKELVDKNIDRFIPVSKLKYYFAVDTVYVGKKLGLLVFPYLHQDWEVQYQQDTPVAPRFDINAPDLYIPAMAFITYILVAGLALGTQDRMIGGVLTGLLFGKIGYYLVLAWCCVSIFVFMIRTLRLKILAQAAAEGVPVRGARNQLRMYLTMAVAAAQPVLMYWLTFHLVR
What is the function of this protein?
Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi (By similarity).  Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (PubMed:18685031).  Plays also a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments (By similarity).
What are the official names of this protein?
Protein YIF1B, YIP1-interacting factor homolog B.
What is the protein family that this protein belongs to?
Belongs to the YIF1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=Shuttles between the endoplasmic reticulum, the intermediate compartment and the Golgi apparatus.
Protein: MEND_PROMT
Sequence: MTISLARYNFFISLELLKTLVAKGVKYFVLCPGSRSGPLALAAASLSKRKELTLITSIDERSAAFLALGISAASGQVSCVITTSGSAVANLLPAAVEADRSCHPLLFLTADRPLRLKECGANQAVNQQDFLKSVCRHFDESPKEGIHLISKERLTSLVGKSFEMASNIPGPVHINLAYEEPLHPCELDQKKVLDGWVIEGFLKGKITPTKDEVVKSFQSLKLLKLDPFSLGIIIVGPWRGKVKQLNSFRGALKKWQKLTGWPILADPLSGVENDQEGLINHWDLFFSIGLFEKIKEIQVLRLGPIPPSRELQTWLKKPGKFQLLITEGDSRNLDPIGGSTQFSEGFSCWVDKMLEVIPVKPAIDKKIVSKKLIKELIKYDLFIHDWLDKRLFRNGLITEPALARLLPRLLPESIPVMIASSSPIRDWLSYSGEGAFLRRCFGFRGASGIDGTLSMGMGLSIIMGRMVLVTGDLALLHDTNGWLFSKDKNISLIVIMIDNGGGGIFNQLNIDRIEEGDFEDIFLMPQQVCHLTLAKAYGLKYKQVACLDDLEKAIEWSFSLSTNVLIRVCTNSIEDHRLRVNLSDDLKKTLSENLSSFD
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: PHNC_TRIV2
Sequence: MSDYVIECHNLETAYVGSLNRPILNEISCHIKQGEFVVLLGLNGAGKSTLLRSLVGLVPLVKGEVHINGVAMNSRILPQIRRDVGMLFQGGGLIPQLSAIENVLCGRLGTRTTWQTLFGFPKRDRLLALELLEQLGLRELAYQRTSKLSGGQQQRVAIARALIQSPQILLADEPTTGLDVIATQQVMETLAELHTQQGMTVVAVLHDLGMAARYAQRAIVLDAGRIVYEGSCDNLQAQFVVNSQ
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYGA_DESAH
Sequence: MNFQDVILTLNNFWAEKGCVLIQSYDTEVGAGTFHPTTLLKALGPEPWKVAYVQPSRRPTDGRYGENPNRLQHYYQYQVIIKPSPSNIQALYIESLKKLGIDPLDHDIRFVEDDWESPTLGASGLGWEVWLDGMEVTQFTYFQMAGSIELKPVSVEITYGLERLCMYLQGVDSVYDLKWNDTITYGDVYHQQEVEQSTYNFEVADTDMLFDFFNKYESEALRIIEKGLVLPAYEFGLKCSHTFNLLDARGAISVTERTGYIGRIRKIARACSNAYVAQREQMGHPLLNRPVKQERKVSK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPI_PHYPA
Sequence: MHTAAQFSISTLNNLYEISSVEVGQHFYWQIGSFEVHAQVLITSWIVIAILLSLAVLATRDLQTIPTSGQNFVEYVLEFIRDLTRTQIGEEEYRPWVPFIGTMFLFIFVSNWSGALLPWRVLELPHGELAAPTNDINTTVALALLTSVAYFYAGLHKRGLNYFGKYIQPTPVLLPINILEDFTKPLSLSFRLFGNILADELVVAVLISLVPLVVPIPMMFLGLFTSAIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ALLC_RALPJ
Sequence: MAMPTLDPNAPDFTRRYPNLADPRLGAEATFATDEFFAPKDRMLNPEPAVFIPGKYDDHGKWMDGWETRRRRNGGYDHCIVRLARPGVVKGVDIDTSHFTGNFPPAASIEAAYLPDGEPTDATQWTEIVPSTTLQGNSHAYVAVASTQAFTHLRVNIFPDGGIARLRVYGQPQVDWKGADRTKLFDLAAMENGAYVVEANNEHFGPASRMLMPGRGVNMGDGWETRRRREPGNDWCVIALANPGRIRKIEVDTAHFKGNFADRVSIQAARVVGGTDSSLKTQAMFWQTLLPEQKLQMDLQHYYEAEIADLGIVTHVRFNMFPDGGVSRLRLWGVIE
What are the official names of this protein?
Probable allantoicase, Allantoate amidinohydrolase.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.
Protein: AROC_PYRNV
Sequence: MNTFGRELRITTFGESHGKAIGVVIDGVPAGLELTEEDIKRELERRMFCHIPVLNPRCEPEEVEILSGVKEGYTQGTPIAVVIWNRRVISSYYEELWMKPRPGHADFAYYLKYGRHYDHRGGGRASGRTTAAVVAAGAVAKKMLALAGAEVAGHIVELGGVEINASYTYEDVKKSWGRPLPVVDQQALDKMLEKIREAAMRGDSIGGGVEVWAVGVPPGLGEPHFGKIKADIAAAAFSIPGAIALDWGMGRALAKMWGSEANDPITVANGRPTLATNKIGGVLGGITVGTPIYFRAWFKPTPSVRKPQQTVDLAKMEPTTIEFKGRYDVSIVPKALVALEAITAVALADHLLRAGLIRRDKPLGR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: NADE_STAAN
Sequence: MSKLQDVIVQEMKVKKRIDSAEEIMELKQFIKNYVQSHSFIKSLVLGISGGQDSTLVGKLVQMSVNELREEGIDCTFIAVKLPYGVQKDADEVDQALRFIEPDEIVTVNIKPAVDQSVQSLKEAGIVLTDFQKGNEKARERMKVQFSIASNRQGIVVGTDHSAENITGFYTKYGDGAADIAPIFGLNKRQGRQLLAYLGAPKELYEKTPTADLEDDKPQLPDEDALGVTYEAIDNYLEGKPVTPEEQKVIENHYIRNAHKRELAYTRYTWPKS
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: DSIP_RABIT
Sequence: WAGGDASGE
What is the function of this protein?
When infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
What are the official names of this protein?
Delta sleep-inducing peptide, DSIP.
Protein: LFTR_VIBPA
Sequence: MAIYLTELDSTFNFPSPYEALSDPNGLLAFGGDLDPHRILSGYYQGIFPWYGPGEPILWWSPSPRAVFDPLTFKPSKSLKKFQRKHQYKVTINQATEHVIQLCSSTRPADETWLNEEMQAAYIQLSNLGHCHSVEVWHDNTLVGGLYGISVGQLFCGESMFSLKDNASKIALWYLCTHLASKHGQLIDCQVMNPHLASLGAFELDRDEFIQKLLSLREKQTASDTFTPQVLQDSES
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SULU_CAEEL
Sequence: MAPAVLQKPGVIKDPSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLFSMNAMSALYHIAQNDPPTLSPIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMYLDETEGKEGSEGNGASDDLDFHGNEANSIGRAGDSASSRSASLTSFRSMQSSGGAGLLVSTNTTGAMDNVHGSSGYGNGSSSTTSSARRRPPIPSQMLSSTSTSGVGTMPSHGSVGASITAIAVNPTPSPSEPIPTSQPTSKSESSSILETAHDDPLDTSIRAPVKDLHMPHRAVKERIATLQNHKFATLRSQRIINQEQEEYTKENNMYEQMSKYKHLRQAHHKELQQFEERCALDREQLRVKMDRELEQLTTTYSKEKMRVRCSQNNELDKRKKDIEDGEKKMKKTKNSQNQQQMKLYSAQQLKEYKYNKEAQKTRLRSLNMPRSTYENAMKEVKADLNRVKDARENDFDEKLRAELEDEIVRYRRQQLSNLHQLEEQLDDEDVNVQERQMDTRHGLLSKQHEMTRDLEIQHLNELHAMKKRHLETQHEAESASQNEYTQRQQDELRKKHAMQSRQQPRDLKIQEAQIRKQYRQVVKTQTRQFKLYLTQMVQVVPKDEQKELTSRLKQDQMQKVALLASQYESQIKKMVQDKTVKLESWQEDEQRVLSEKLEKELEELIAYQKKTRATLEEQIKKERTALEERIGTRRAMLEQKIIEEREQMGEMRRLKKEQIRDRHSQERHRLENHFVRTGSTSRSSGGIAPGVGNSSSIQMAM
What is the function of this protein?
Acts as a negative regulator of cortical contractions during early embryonic cell division, possibly by regulating rho-1-dependent actomyosin contractility (PubMed:23064028).  Plays a role in polarity establishment in early embryos by regulating the size of the anterior and posterior cortex in the first asymmetric cell division (PubMed:23064028).  Might play a role in cell cycle progression (PubMed:23064028).  In the germline, involved in the regulation of meiotic progression during oogenesis, possibly by modulating the timing of mpk-1 activation (PubMed:26510792).  Plays a role in meiotic recombination events (PubMed:26510792).  Involved in pharyngeal pumping (PubMed:11733138).
What are the official names of this protein?
Serine/threonine-protein kinase SULU, Protein kinase 18.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Localized to the anterior cortex in embryos; localization to the anterior cortex depends on par-3 and rho- 1.
Protein: SECA_LEUCK
Sequence: MANPIRKLVDNSKKQLKKLNHIADKVEDYADEMAALSDEALQAKTPVFKEKIADALRDVTETDKQNKVLAKTLDALLPEAFAVAREAAKRVLGLYPFRVQIMGAAVLNDGNLAEMRTGEGKTLTATMAVYLNALTDRGVHVVTVNDYLSARDAEQMGQLYNWLGLSVGVNVGDAPAEEKRAAYDADITYSTNFNIGFDYLRDNMVRRAEERVMQRGLNFALIDEADSILIDTARTPLIISGPGSGVSQLYGRADRFVKTLQQDEDYKIDEEAKTTMLTNDGIHKGEIFFNLDNLYDAGDTALTHHIDQALRANFNYINDKDYVVQDGEVKLIDQSTGRISEGTRLSDGLHQAIEAKEGVEIQEENKSMAQITYQNLFRMYKKLSGMTGTAKTEEEELREIYNMEVITIPTNRPIKRVDYPDLLYPSIRAKYNAVVKLIQELHEKGQPILIGTGSVESSELLSKILMAQNVPHNVLNAKNNAKEAEIIANAGQRGAVTVATNMAGRGTDIKLGPGVADLGGLAVIATERHESRRIDNQLRGRAGRQGDDGFSQFFLSLEDDLMIRFGAERIRAVWERMNLDEEETVIKNRLITRSVESAQKRVEGNNYDTRKNVLQYDDVVREQRELIYHQRDIIIDESQSLDWVLMPMVSRTINRVVTVQTKSKKPSEWQLQQIIVFAENVLVNEGALTENDLSGLSREDIEAKLYALAKENYANKKRQLYEPEQMLEFEKVVILRAVDQHWTDHIDALDRLRQGVGLRGYGQLNPLIEYQNEAFENFNKMIADVEYDATRTFMKAEIRQNLKA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: MSCL_LACPL
Sequence: MIKEFKEFIARGNVIDLAVGVIIGSAFTAIVKSLTDNLINPLIGIFLGKVDLSNLKFSIGDATFKYGSFLNAIINFFIVAIVVFILVKIINKVVKNEPEEPEEEEVDVSAQYLEEIRDLLKEQAKK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS14Z_STAAM
Sequence: MAKTSMVAKQQKKQKYAVREYTRCERCGRPHSVYRKFKLCRICFRELAYKGQIPGVRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: HEMA_I96A3
Sequence: MKAKLLVLLCTFTATYADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECESLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVSASCSHNGKSSFYRNLLWLTEKNGLYPNLSKSYVNNKEKEVLVLWGVHHPSNIGVQRAIYHTENAYVSVVSSHYSRRFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFESGIITSNAPMNECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSRGLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLERRMENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNNECMESVKNGTYDYPKYSEESKLNREKIDGVKLESMGVYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: Y1085_CROS5
Sequence: MFRIYTAHSLGQKWVENYQECSAIFACIVGFTETGLIPGISAAGATPEARKYTAIADAEFLINGVQSSYHYPLPPLSQGVSPVFITRAVVEACNIPIYLFNAGLPTPPSVPYIDLKGKSANCLTTGKALPLPLVYELFQQGLKWGKKLAKDHTKNYLILSECVVGGTTTALSILTGLGINATEKVNSSHPHCNHKQKELIVKEGFKNAGYSYNLKPINPFELVAAVGDPMQIVVAGMAISASLKTGVMLAGGTQMLAVYALIKSIINTSKYQGNLDNIIVGTTRWVAEDLTGDTVTLAESIGTVPLFATQLNFSSSSYQQLQMYEQGYVKEGVGAGGCAIAASLSYNWTQEKLLNRIENLVNNYHRIRN
What are the official names of this protein?
UPF0284 protein cce_1085.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: RL30_SULAC
Sequence: MNELIGVIRIRGWAATPWYIQDTLSMLRLKNAFNAMIYPKDSSIQGMLNLVSSYVTWGELNDEGLRLLVSKLEISRGKKVNEEYVKDKLNVDFQSFVESIKDGKLRLNKLDEIFSLPIRLHPPKGGFKGKVSRPFRAGGEFGYRGDKINELIRRMV
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: HOA5_RHOJR
Sequence: MTTRLFIQDVTLRDGMHAVRHRITPDDVGKIVAALDAAGVDGIEVAHGDGLAGGSLNYGPGSNTDWEWIEAAADNLTHARLTTLLLPGIGTIAELEHAYVLGVRSIRIATHCTEADVSAQHIGKARELGMDVSGFLMMSHMASPAELAAQAKLMESYGAHCVYVTDSGGRLTMDGVRERVRAYRDVLDEATEIGIHAHENLSLSVANSVVAVEEGVTRVDASLAGHGAGAGNCPIEPFIAVADLQGWKHNSDLFALQDAADDLVRPLQDRPVRVDRETLTLGYAGVYSSFLRHAEAASQRYGIDVRTILLEVGRRGLVGGQEDLIVDIALDLLAANSDSVAS
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 5, HOA 5, 4-hydroxy-2-keto-pentanoic acid aldolase 5, 4-hydroxy-2-oxopentanoate aldolase 5.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: SC5A8_HUMAN
Sequence: MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQIYPPLPERTLPLHLDIQGCNSTYNETNLMTTTEMPFTTSVFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYILTKEDFLSNFDIFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSDQSGKSNGTRL
What is the function of this protein?
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1.  Catalyzes passive carrier mediated diffusion of iodide.  Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane.  May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract.  Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines.  May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
What are the official names of this protein?
Sodium-coupled monocarboxylate transporter 1, Apical iodide transporter, Electrogenic sodium monocarboxylate cotransporter, Sodium iodide-related cotransporter, Solute carrier family 5 member 8.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein: SELO_ECOLC
Sequence: MTLSFVTRWRDELPETYTALSPTPLNNARLIWHNTELANTLSIPSSLFKNGAGVWGGEALLPGMSPLAQVYSGHQFGVWAGQLGDGRGILLGEQLLADGTTMDWHLKGAGLTPYSRMGDGRAVLRSTIRESLASEAMHYLGIPTTRALSIVTSDSPVYRETAEPGAMLMRVAPSHLRFGHFEHFYYRRESEKVRQLADFAIRHYWSHLEDDEDKYRLWFSDVVARTASLIAQWQTVGFAHGVMNTDNMSLLGLTLDYGPFGFLDDYEPGFICNHSDHQGRYSFDNQPAVALWNLQRLAQTLSPFVAVDALNEALDSYQQVLLTHYGQRMRQKLGFMTEQKEDNALLNELFSLMARERSDYTRTFRMLSLTEQHSAASPLRDEFIDRAAFDDWFARYRGRLQQDEVSDSERQQLMQSVNPALVLRNWLAQRAIEAAEKGDMMELHRLHEALRNPFSDRDDDYVSRPPDWGKRLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: RLMC_SHEPA
Sequence: MKCAHFDQQQCLSCRHIKQSMSVQVAAKSQVLSQLLSDFEVEQWHEPVFGPDSGFRNKAKMVVLGAAHQPILGIVTPTGEPVSLCDCNLYPEDMQLLLHRLEQFVRQAGIPPYNVDKAKGELKFILLTRSQIKGEYLLRFVLKSHKSIERIERELPKLLSEYPQIKVVSVNIQPVHMAILEGEEEIFLTEETRLSEQFNDVPLFIRPKSFFQTHPQIAAKLYQTAREWVAELKPSSLWDLFCGVGGFGLHCASKTIPLTGIEISSEAIACAKISAETMGLTQVDFTALDSTGFAQGCDATDKPDVVIVNPPRRGIGESLCQSLSDFAPKAILYSSCNPHTLAKDLANIQGYHIQKVQLFDMFPHTDHFEVLVMLVKPS
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: CMOB_HELPH
Sequence: MLTCNDKINPKTLLEEIMALRPWRKGPFEISQIKIDSEWDSSIKWDLVKNATLLKDKVVADVGCNNGYYLFKMLEHGPKSLVGFDPGVLVKKQFEFLAPFFDKEKKIIYESLGVEDLHEKYPNAFDVIFCLGVLYHRKSPLEALKALYHALKIKGELVLDTLIIDSPLDIALCPKKTYAKMKNVYFIPSVSALKGWCERVGFENFEILSVLKTTPKEQRKTDFILGQSLEDFLDETDHSKTLEGYDAPLRGYFKMLKPSKR
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: M21_HRSVA
Sequence: MSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT
What is the function of this protein?
Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription (PubMed:19386701, PubMed:22675274).  Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription (PubMed:10364337, PubMed:27194388, PubMed:8552680, PubMed:9420254).  Preferentially binds to poly(A)-rich sequences (PubMed:24434552).  Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding (PubMed:18579594).  Also, can activate host NF-kappa-B through association with host RELA (PubMed:15629770).
What are the official names of this protein?
Protein M2-1, Envelope-associated 22 kDa protein, Transcription antitermination factor M2-1, Vp24.
What is the protein family that this protein belongs to?
Belongs to the pneumoviridae M2-1 protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus. Note=Localizes in cytoplasmic inclusion bodies substructures called inclusion bodies associated granules (IBAGs) (PubMed:22675274, PubMed:28916773, PubMed:29489893, PubMed:31649314). Forms a layer between the matrix and nucleocapsid (PubMed:23776214, PubMed:24760890).
Protein: HFQ_YERPY
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQVESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNTPSGSTNNYHGSNPSAPQQPQQDSDDAE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: RL23_SYNS3
Sequence: MTERFTGRLADVIRRPLITEKATRALEQNQYTFEVDHRAAKPDIKAAVEQLFDVKVTGISTMNPPRRSRRIGRFAGKRAQVKKAVVRLAEGNSIQLFPES
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: YKD6_CAEEL
Sequence: MTADSLRERLKSQNADYSLLNTSQASNRSAFEDKMSPVCKSRYVNDNQRLEQSRITMLETRIKWHIILLTGFSIDHLVLNSSFTSAILLFGFFPSYVNSSISLFVIIYSLIMIASYAFEIKFPNALKQLVYNKVQSKPPRPESSKSTPIVPDAQNVLDTSVQSNDLSWVDAHRFGTPSFKSSQLQQSPSPNKKSPSYSQVMSNVSVSDTSGILEDTKGGWKSPAVYGKSNESIHTRKQLDVLLRSNQDEIPVDMNTSTFSSIWSVFGLGRSGQISANNTWQVSEEITNDGNTNSSYRMKIGKNGRTEVKMLRRGKDGEIEEEDEDELVRLHKILNAAKLTPEGKTGILKRSNSIDRAGIRSRRRSHSSPERSTSTENEIRYQTGELLTEDQQKRAEFMTRAWIRNTILEPLAEHIDKVNKILDKEHANPPLRVGVSSVDALKLAAIERDSLKSSDLPFLLPFLSVHPNQKYLISRIKELCATQFMDAYKWNSGGSEPTDDNDQMTRLVRREWNDSLPTDAVLVFDIFLAYMDAQLNSNCLVGDSRLDQPFTSRFCVKNAQKPSSAQRTPFSFYLHMVTKSPPHAEFVHIDENGYAIKCNVLRQSPNLFRAIAQFIHFVKHENHGYLDQTSIGPSGINMTYVLA
What are the official names of this protein?
Uncharacterized protein B0464.6.