PharMolix/UniProtQA huggingface dataset:
Protein: RHMA_ECOHS
Sequence: MNALLSNPFKERLRKGEVQIGLWLSSTTAYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAVAPYASQPVIRPVEGSKPLIKQVLDIGAQTLLIPMVDTAEQARQVVSATRYPPYGERGVGASVARAARWGRIENYMAQVNDSLCLLVQVESKTALDNLDEILDVEGIDGVFIGPADLSASLGYPDNAGHPEVQRIIETSIRRIRAAGKAAGFLAVAPDMAQQCLAWGANFVAVGVDTMLYSDALDQRLAMFKSGKNGPRIKGSY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
What are the official names of this protein?
2-keto-3-deoxy-L-rhamnonate aldolase, KDR aldolase, 2-dehydro-3-deoxyrhamnonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
Protein: GCSPB_STAA1
Sequence: MTSKSSPLIFERSREGRYAYSLPKSDIKTNSVESLLDDKFIRKNKAEFPEVAELDLVRHYTELSNKNFGVDNGFYPLGSCTMKYNPKINEKVARIPGFSESHPLQDEDQVQGSLEIIYSLQEELKEITGMDEVTLQPAAGAHGEWTALMIFKAYHENNGEGHRDEVIVPDSAHGTNPASASFAGFKSVTVKSNERGEVDIDDLKRVVNENTAAIMLTNPNTLGIFEKNIMEIREIVHNAGGLLYYDGANLNAIMDKVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVVKELASYLPKPMVIKDGDKFKYDNDIKNSIGRVKPFYGNFGIYLRAYTYIRTMGATGLKEVSEAAVLNANYIKARLSEHFEIPYKQYCKHEFVLSGVRQKEFGVRTLDMAKRLLDFGVHPPTIYFPLNVEEGMMIEPTETESKETLDYFIDTLISIAEEAKNDPDKVLEAPHTTVIDRLDEATAARKPILKFENLKQEK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: OPDD_PENO1
Sequence: MDLTLARTMEILRPLGLADGLRARGVPSTYPFTVRFSSGLGMKHSLSEWKLPSADQLRERIMSQNDGTMPLEPWLRVSGDVMEAFLKEKCEESHLVTLRFGWSVTQVIESATEVETRVRNPHTGGEKVIRSQYAVGCDGASSLVRKNMGIALDGGPIHSSVVLIHFKSRDLTRLHRQGRFWHTFFLLDPTISGDSVGGAIIAQDEVDTWTVHDFRAPGSKQSISCAEETIYRVLGAMGGPYPITIDEIIQQSTWTPSIALAKSYTGPLHRVFLAGDACHQTIPSGGYGMNMGIADVFDLGWKLAAMIQGWGGAQLVLSYEQERRPVAELMQHWGKVHAGKLMGLASAVTLNATIIDASDARGEEMRQKIHEYVQSNDAHNQCFGVEHGHQHHSDITVTSASSHPPFDPRSYTPTTHPGFRAPHVFLNDGSAIFDKFGKTLTLVEFIDAMPGPSSGGSFFRDTADEHHIPLRIASLVGEANAQQIWGARLVLVRPDHFVSWCGNDVGSKDEAKRVLLQAAGHICR
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of oxopyrrolidines, polyketide-amino acid hybrid compounds with feature structures of tetramic acid (PubMed:36005526).  Does not seem to play a role in oxopyrrolidines A and B biosynthesis (PubMed:36005526).  May be involved in further modifications of these oxopyrrolidines (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase opdD, Oxopyrrolidines biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: YDAL_BACSU
Sequence: MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVKMLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVVAIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFKADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISPMSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGGSIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSYLEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQVQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFEGGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQVKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERRSLG
What are the official names of this protein?
Uncharacterized protein YdaL.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: IL13_MOUSE
Sequence: MALWVTAVLALACLGGLAAPGPVPRSVSLPLTLKELIEELSNITQDQTPLCNGSMVWSVDLAAGGFCVALDSLTNISNCNAIYRTQRILHGLCNRKAPTTVSSLPDTKIEVAHFITKLLSYTKQLFRHGPF
What is the function of this protein?
Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:15361238).  Synergizes with IL2 in regulating interferon-gamma synthesis.  Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity).  Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (PubMed:34789557).  Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity).  Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils.  Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:8871614, PubMed:34795444).  Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:29305434).
What are the official names of this protein?
Interleukin-13, IL-13, T-cell activation protein P600.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBL_PROM4
Sequence: MQVNPNPNKLPVELNRTSLYLGLLLTFVMGILFSSYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: YB74_YEAST
Sequence: MIFDSLTMTQSSLSLLLLTGAIFSISALYLTLFHRCATFSATSDLFLLVPLKFVSRDINDRLKTHYHHSCLGSPFLCIIFLFISPLLNYHFRSLVRPPKIHQKGSIPTLTKNAETRCSHHLKQAAATGEVCKVVVIIKGHILKDCSIFFFIIFPLIYPLFINCSSKYNGLQ
What are the official names of this protein?
Putative uncharacterized membrane protein YBR224W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SIA7C_HUMAN
Sequence: MACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRTHYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYGMINDTYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHPNWTLS
What is the function of this protein?
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage.  Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains.  ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:16169874, PubMed:17123352).  GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity).  Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (PubMed:17123352).
What are the official names of this protein?
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, GalNAc alpha-2,6-sialyltransferase III, ST6GalNAc III, ST6GalNAcIII, STY, Sialyltransferase 7C, SIAT7-C.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: LEUC_LEPIN
Sequence: MKTMFEKIWEDHLVGELDAGSYLIYIDRHLIHEVTSPQAFEGLKLAGRKVRRPEATFATMDHNVSTRTRDLSLADPVSAIQMQTLKKNCDENGIRVYDFQNPDQGIIHVIAPEMGLTHPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLVQKRAKTMEIRVDGKLSDKVTAKDIILAIIGKIGTAGATGYVIEYRGSAIQALSMEARMTICNMSIEAGARAGLIAPDETTFNYIQGKDFSPKGVEWDLAVKKWKHYVTDEGAKFDRTVILHADEIAPMVTWGTSPSQVVSIKGVVPDPKDANDPVEKIGIESALKYMDLKSGQKIEDISINKVFIGSCTNSRIEDLRAAAATVKGKKVSSKVQAIVVPGSGRVKRQAEQEGLDKIFTAAGFEWRNPGCSMCLAMNDDVLEPGDRCASTSNRNFEGRQGKGGRTHLVGPEMAAAAAIEGHFVDIRNWK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: COX8C_EULFU
Sequence: MAHLPRVCPFIRRLRVALLCLRPGHRFAHSEPQRQRPASALEMAVGIVVIFSAFLTPSAYVLSNLSQFRRE
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 8C, mitochondrial, Cytochrome c oxidase polypeptide 8 isoform 3, Cytochrome c oxidase polypeptide VIII isoform 3, COX VIII-3, Cytochrome c oxidase subunit 8-3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIII family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: UBIA_SHEAM
Sequence: MSKMAQKWDAYYRLMRLDRPIGTMLLLWPCLMALLLAADGMPDLRVLIIFIIGVVVMRACGCIINDYADRKLDSHVARTRSRPLASGEVTVAEALTLFVVLGLFAFSLVLLLNPLVVQLSVVGIILTIIYPFTKRWTNMPQMFLGVVWSWSIPMAYAAQTGEVPASAWWLFAANWCWTVAYDTMYAMVDRDDDLKVGIKSTAILFGRFDREIIGAFQLAALGCFIAAGWSGDRGLLYGLGVLTFVGFSAYQQRLIYGRERGDCFKAFLNNNWAGLSLFLALGADYAFAAL
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRPE_SYNS9
Sequence: MSGDASTSAQDQNVESNDVPAIPDVDAGTPIDPVVEETPTLDTEIDPANRLQQLEQELNSLKQEHEAVQSQYMRIAADFDNFRKRQARDQDDLRQQLVCSTLTEILPVVDNFERARQQLNPEGEEAQALHRSYQGLYKQLVDVLKQQGVARMEVVGQEFDPTLHEAVLREENQEHAEDIVCEELQRGYHRDGRVLRHAMVKVSMGPGPESSSDAASEQPQEGDA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_TRIEI
Sequence: MYLKHLHLRQFRNYRDQQVKFDGAKTILLGDNAQGKSNLLESVELLSTLKSHRAIRDRDLILDSKQASKIQASLERQLGNIDLALTLRSQGKRTVAVNGETISRHLDFLSILNVVHFSSLDLDLVRGGPEVRRYWLDRLLVQLEPVYAHILLQYNQVLRQRNALLKKIRQQKMAAETTGSSPSILTQELALWDAQLATTGSRVIRRRQRLLQKLAPLAGEWHCAISGSMEVFKMEYLANVIVDSNELIIQDSLEGVRQAFLEKIKVRAIAEQYQGTTVVGPHRDDVIFTINDTPARQYGSQGQQRTLVLALKLAELQLIEEVVQEPPLLLLDDVLAELDLHRQNQLLEAISNRFQTLITTTHLGCFDGQWLQDTQILSVKSGNISSFLDF
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BBP_NEUCR
Sequence: MSWRNQGITGSNNIPLGSRRRFAGDGEEEDGARSVTPSAPSSVTNGDRDRDRDGPVYSNDRDVKRGRSPERSEDGPKRRKKRNRWGEATENKAAGLMGLPTAIVANMTSEQLEAYTLHLRIEEITQKLKIDDVVPADGDRSPSPAPQYDNHGRRVNTREYRYRKKLEDERHKLIEKAMKTIPNYHPPSDYRRPTKTQEKVYVPVNDYPEINFIGLLIGPRGNTLKKMETESGAKIAIRGKGSVKEGKGRSDAAHSSNQEEDLHCLIMADTEEKVNKAKKLIHNIIETAASIPEGQNELKRNQLRELAALNGTLRDDENQACQNCGQIGHRKYDCPEKQNYTANIICRVCGNAGHMARDCPDRQRGASWRNDGPGAGRTAGRIGSSGGGDAVDREYEQLMQELGGTGAAPARIEAGPGSFSNGPSGGNGDAKPWQRGPTGGPAPWRTRNMDRDHEGGPGGPPSGPSGGPAPWARDRNERRHDDRDRGDSYYGGDRRHDDYGRGSSGGGGPAPWHQPPPGAPSAPAIPTAPAYPGAYGGYPGYGAPPGMGAAPPPGLPPPPPGAPPGLSGPLNALIQQYANAAPPPPPPAAEAPPPPPMDLPPPPPPGA
What is the function of this protein?
Necessary for the splicing of pre-mRNA.  Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity).
What are the official names of this protein?
Branchpoint-bridging protein.
What is the protein family that this protein belongs to?
Belongs to the BBP/SF1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AZOR_ALBFT
Sequence: MKLLHVDSSILGTYSVSRQLSAEIVAEWRKSRPDTTVEYLDLALNAPNHFGADAIAIKGIAQPEPTEAQRAENALSEQLVSQFLASDVIVIGAPFYNFSIPTQLKAWIDRLAQPGRTFTYNEKGPLGLATGKTVIVASTRGGAYSTSEGGQAMEHQESYLKVVFGFFGITDVRIVRAEGLAMGDAPKAAALSAARADMELATA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: MURB_AZOC5
Sequence: MTTPAFPDLVPALAAALPELRGKLTANAPIADVTWFRVGGPAQVLFQPADEADLAYALAHLPAEIPVTVIGLGSNLIVRDGGVPGMVIRLGRGFTDIAVDGTTIVAGAGVPDVKVARAAADAGLAGLAFLRGIPGAIGGALRMNGGAYGGETKDALMSARAVDRAGRIHILSLDDMGFTYRHSAAPEDFIFTQATFRGTPGEVAEIQAEMERITSSREATQPIKSRTGGSTFKNPPGHKAWQLVDAAGCRGLVLGRAQVSEMHTNFLINLGCATAAEIEGLGEEVRRRVLETSGVTLEWEIKRIGLPA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLTF_AERHH
Sequence: MPIFSTRVLTYLRCIFRLFIGLTLLLTLVGCDFYTPSSQLEQIRQRGEIRVGTIYGPTSYYQRDDTAQGFDYELAQSYADWLGVKLTIVPVYSTAELVELLRKGKLDLAAAAIVVTPERRQLFRFGPGFYQVSPKLVYRNGSPKPKDIGDLKGNIVVPAGSTGEDLLKELAKQYPNLKWSTNRDADVEELLKQVADGKIDYTVVQDTVLARTQRYYPELTEGMTLAKNQTVAWAMTKLPDDSLYASIIDFFGQRFMDGAIAKLDEKYFGHVQNFDFVDTRTFLQRAKSLLPKYQDLFKTHANVVDWRLLAAISYQESHWDPEARSYTGVRGMMMLTEPTAKAMGVNNRLHPEESIKGGARYLEQMMEKVPASVPDDEKVWFALTAYNIGYGHMMDARRLTKELGKNPDAWSDVKEVLPLLQQSRWHRKVRYGYARGGEARNYVNNVRQYYQSLLWLDNEQQKAHRREELDDDDSSEPPSAERPTVIAEVVKQITLR
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: LPXA_ALISL
Sequence: MIHETAQIHPSAVIEGDVTIEANVSVGPFSYISGNVTIGEGTEVMSHVVIKGDTIIGKDNRIFSFAIIGEESQDKKYGGEATKVVVGDRNFIRESVQIHRGTVQDRGVTTVGNDNLLCVNVHIAHDCIVGSNIIMGNNATLAGHVTIEDYAIVSALSPVHQFCTVGAHSFIGGASVVVQDVPPFVMAQGNHCKPFGINIEGLKRRGFEKPEIHAIRRAYKALYRNGNTLEEAKEEIKTEIEAFPVLQGFLDLFEKSTRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: E1A_ADECT
Sequence: MKYTIVPAPRNLHDYVLELLEEWQPDCLDCEYSHGSPSPPTLHDLFDVELETSHSPFVGLCDSCAEADTDSSASTEADSGFSPLSTPPVSPIPPHPTSPASISDDMLLCLEEMPTFDDEDEVRSAATTFERWENTFDPHVGPIFGCLRCAFYQEQDDNALCGLCYLKALAEEPASAGAEEEDDEVIFVSAKPGGRKRSAATPCEPDGVSKRPCVPEPEQTEPLDLSLKPRPN
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E1A protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome.  Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore.  This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K.  Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection.  Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation.  The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif.
What are the official names of this protein?
Early E1A protein, Early E1A 25 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1A protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: SYH_EHRRG
Sequence: MQHNKLREVRGTKDLLDDELYRFQYIQHLAQTIASRYGFIPVDTPIIEFTEVFTKLGNTSDIVTKEMYNFKDKAGEDITLRPEFTSAIVRLLISKNLTIPVKLFSSGPVFRYERPQKCRQRQFHQINFEFFGSDSPIADVEMISLCYNILSELKLSDRIKLEINFLGDQETINSYKIHLVEYLNKYQKDLSEDSQRRLVVNPLRILDSKSPEDCKILLNAPSISDFYTQNSQNFFKEVLDGLDNLSINYVINHNIVRGLDYYCKTVFEFTTSELGSQNSVIAGGRYDGLVKSMGGHSTPAIGFAAGVERLSALIDYEHKKPKRIVLIPIGDDATSYAIKLAYELRCKGIHVCWNNYRGTSLKNELRKANDTDIVLIFGDEELQSNTVKVKDMKTGDQQNVAVCDLLDNLLHRIV
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_AGRFC
Sequence: MAKTSAVEKNKRRRKSVAQQATKRAALKAIVMNQSLPIEDRFKATLKLASLPRDGSKTRIRNRCEVTGRPRAFYRKLKMSRIALRELGNSGKVPGIVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: OL476_MOUSE
Sequence: METQNHTTVTEFILLGLTESSTLRVILFMVFLGIYTVTLVGNFSIISLIRSCPQLHTPMYLFLSHLAFVDIGFSTSITPTMFKGFLGNRLVLSVAACIAQFCITVTFGTVECFLLAVMAYDRYVAICSPLLYSTHMSPRICFLLVGASYVGGCVNSGAFTSCLSILSFCGPNQIDHFFCDFPAVLKLSCSDVSIIGIIPSISAGSIIVITVFVIAVSYAYILITILKMRSTEGRQKAFSTCTSHLTAVTLYYGTITFIYVMPKSNYSTAQNKILSVFYTVVIPMLNPLIYSLRNRDVKEALRKAIIRIFP
What is the function of this protein?
Potential odorant receptor.
What are the official names of this protein?
Olfactory receptor 476, Olfactory receptor 204-3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRC_CLOBA
Sequence: MELLIKNARIIDAIQDFKGDIYIKDGVINEIAKEINKDNVEVLNCEEKILMPAFIDTHAHFRDPGLTWKEDLESGSKAALKGGYTGVCLMANTKPICSSKEVVQYVRDKSKELDLIDIHQCISVTQNFDGKTLDHLNEFKDDNKVKAISDDGVGVSNSNIMLEAMKIAKENNWVLMSHAESPEFSKSDMRIAENMMTIRDVELAKLSGAHVHMCHVSTKEALKCIIAAKNEGANITLEVTPHHIGLTKEINDYRVNPPIREKEDVEEIIKAIKMGNIDTIGTDHAPHTLEEKSKGSPGMVGLETAFPICYTKLVRENGVSLNELSKLMSLNPAKLLGMNKGKISIGVDADLVLIDIDKKIKVDSNEFISKGRNTPFEGMEYYGEVLATIKSGKIKYKK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: PXPA_ECOLC
Sequence: MKIDLNADLGEGCASDAELLTLVSSANIACGFHAGDAQTMQACVREAIKNGVAIGAHPSFPDRENFGRSAMQLPPETVYAQTLYQIGALATIARAQGGVMRHVKPHGMLYNQAAKEAQLADAIARAVYACDPALILVGLAGSELIRAGKQYGLTTREEVFADRGYQADGSLVPRSQPGALIENEEQALAQTLEMVQHGRVKSITGEWATVTAQTVCLHGDGEHALAFARRLRSTFAEKEIVVAA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.