PharMolix/UniProtQA huggingface dataset:
Protein: RUVA_METC4
Sequence: MIGKLKGIVDSYGEDFVILDVNGVGYVVHCSARTLQRLPKPGEATDLAIETHVREDMIRLYGFRVDAEREWFRLLQTVQGVGTRVALGVLSVLEPAQLATAIATGDKGAVARAPGVGPRLAARLVAELKDKAPAFAPIDPALIALTGAVEDRTAPQPVADAISALVNLGYAQIQASAAIAAALKGLGEEAGTVEAKTLIRLGLRELAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: DB10_NICSY
Sequence: MAVVTASSAGPSYAPEDPTLPKPWKGLVDGTTGFIYFWNPETNDTQYERPVPSSHAVSAPAHKSSVFVSSSVEKPSQGQRYDADGGHNRGSNNKIARSSSDRFHDGTSVHEGYGSLGVGSDISQESYCRRNEISVTGGDVPAPLTSFEATGFPSEIVREMHQAGFSAPTPIQAQSWPIALQGRDIVAIAKTGSGKTLGYLMPAFIHLQQRRKNPQLGPTILVLSPTRELATQIQAEAVKFGKSSRISCTCLYGGAPKGPQLRELSRGVDIVVATPGRLNDILEMRRVSLGQVSYLVLDEADRMLDMGFEPQIRKIVKEVPVQRQTLMYTATWPKGVRKIAADLLVNSVQVNIGNVDELVANKSITQHIEVVLPMEKQRRVEQILRSKEPGSKIIIFCSTKKMCDQLSRNLTRNFGAAAIHGDKSQGERDYVLSQFRAGRSPVLVATDVAARGLDIKDIRVVINYDFPTGIEDYVHRIGRTGRAGASGLAYTFFSDQDSKHALDLVKVLEGANQCVPTELRDMASRGGGMGRARNHWGSGPGGRGGRGGPYNSSYVGRNGGHGYDRGSRDSDRYGHGTYNADAPRKRSRSRSPNIGSGWSGKKSRFTD
What are the official names of this protein?
ATP-dependent RNA helicase-like protein DB10.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family.
Protein: FABZ_BORA1
Sequence: MELDIKGIMERLPHRYPMLLIDRVLEMVPGKSIVAVKNVSINEPFFNGHFPHHPVMPGVLIVEAMAQASALFSFTDDNGGLKADAGKTAYYLVGIDGARFRRPVVPGDQLRIEVEAERLSRTICKYQGRALVDGQLVAEAKLMCAIRSLEE
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_VIBCM
Sequence: MSVKIHYQNTHFITSAPDIRHLPEDEGIEIAFAGRSNAGKSSSLNRLTNQKNLAKTSKTPGRTQLINLFKVADGCHIVDLPGYGFAQVPLEMKLKWQRALGEYLQKRQSLKGLVVLMDIRHPMKDLDQQLIIWAVECGIPVQVMLTKADKLKSGARKAQVLKVREEAKTFGGDVAVDAFSSLSGIGVDTLRAKLDEWYAPMLAALAEQEEGEQPESSTDQ
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: MTC2_YEAS7
Sequence: MGDHNLPDFQTCLKFSVTAKKSFLCMYRDSVSKEKLASSMPSTCDIQLKRAINDAYPGGGIKVTVLNSTTASLDSLATTHVKEFEIVIIPDINSLLQPDQAKLVKIMRDCTVAIEKAQSTRIFIGVVHWNNPVQPSGAAKDGDEAGKPAPKTRIFLPTSFRMGAWLKHKFWFACAPPYLDFESSTESSINTRANNSIGMAEEEKQEPESKRSIILNEEANLNDVFVGSTVRRYILDIMVHLRTHRLTYNAKAGGVYTNSLDDVVLLSRLIGLHSGKMFVSPSHVKEASRWYFPMHLELVQRSSMDSSLLYGSDPNLVDEMLEKLAKIKCEEVNEFENPLFLESLVVKNVLSKVVPPV
What is the function of this protein?
May be involved in telomere capping.
What are the official names of this protein?
Maintenance of telomere capping protein 2.
What is the protein family that this protein belongs to?
Belongs to the MTC2 family.
Protein: TYSY_NITEU
Sequence: MYQYLDLMRHVLQYGHKKSDRTGTGTLSVFGYQMRFDLQTGFPLVTTKKCHVKSIIHELLWFLRGETNIDYLKRNGVSIWDEWADENGDLGPIYGHQWRSWAASDGTVIDQISQVIQQIKETPDSRRMIVSAWNVGDLDKMKLAPCHVLFQFYVADGRLSCQLYQRSADIFLGVPFNIASYSLLTLMIAQCCDLQPGEFVHTFGDAHLYLNHLEQARLQLEREPRALPAMQLNSTVRNIFDFGYEDFTLHDYDPYPPIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1105_HALWD
Sequence: MSETPDDLDELRQQRMEELRDQADGQQSQTSDNTAAAQEAAREKAEAQQEALLKQHLTDGARQRLNAIEMSKPDFAEKVKKQLVTLAQSGRIQDRIDEDQMRELLQELKPDSKSYNIRRR
What are the official names of this protein?
DNA-binding protein HQ_1105A.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: YAB4_ORYSJ
Sequence: MSSSSSSSAVFPLDHLAAPSPTEQLCYVHCNCCDTILAVGVPCSSLFKTVTVRCGHCANLLSVNLRGLLLPAPAPAPANQLHFGPSLLSPTSPHGLLDEVAFQTPSLLMEQAASASLSSITGRSSSSCASNAPAMQMPPAKPVQQEPELPKNAPASANRPPEKRQRVPSAYNRFIKDEIQRIKAGNPDISHREAFSAAAKNWAHFPHIHFGLMPDQGFKKTFKPQDGSEDILLKDSLYAAAAAAAAAAANMGVTPF
What is the function of this protein?
Seems to be associated with phloem cell differentiation.
What are the official names of this protein?
Protein YABBY 4, OsYAB7, OsYABBY4.
What is the protein family that this protein belongs to?
Belongs to the YABBY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS12_PICTO
Sequence: MANGLNAGKKLMKSRKTYRWSDRDYKRRVLNLKKKSDPLEGAPQAKGIVIEKVGIEAKQPNSGIRKCVKIQLIKNGRQLSAFAPGDGAINYIDEHDEVVVEGIGGRMGRSKGDIPGVRYKVIKVNGISLHELVKGRKEKTVR
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RUVA_YERPS
Sequence: MIGRLRGIILEKQPPLVLLETNGVGYEVQLPMTCFYELPELGQEAIIFTQFVVREDAQLLYGFNNKQERALFRELIKVNGVGPKLALAILSGMSAQQFVGAVEREDITTLVKLPGVGKKTAERLVVEMKDRFKGLNGDLFNNTGDISLPTASPQTSDADIEAEAASALVALGYKPQEASRLVSKIAKPGADCETLIRDALRAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RL3_NITOC
Sequence: MAIGLIGRKVGMTRVFTDEGASIPVTVIEATPNRISQVKTLEQDGYQAVQVTVGERRPARVTSSLKGHFAKANVEPGRKLQEFRFGAEEGRDIKASGELKVDLFEVGQKVDVTGITRGRGFAGVVRRYHFGGGDASHGNSLSHRAPGSIGQCQTPGRVFKGKKMAGQMGNVRRTVQNLELVRIDEGRQLLLIKGAIPGAPGGDVIVKPAVKTVVK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: YDHL_ECOLI
Sequence: MAEQLEFFPVQSPCRGICQSDERGFCRGCFRSRDERFNWNKMSDGEKQEVLRLCRQRLMRKLRANKPASSDEPEQPSLF
What are the official names of this protein?
Uncharacterized protein YdhL.
Protein: RSMH_BORA1
Sequence: MKFEHRPVLLEPTVDALLQADFGGRGASRARPRDEAAALTRQATGIFVDGTFGRGGHSRELLGRLGPQARLVVFDKDPEAIAVAQALAAEDARVTVVHGGFATMTEELAARGIERIDGVMLDLGVSSPQIDDADRGFSFMREGPLDMRMDTSRGPTVADWLAQASVEEMREVIADYGEERFAFQVAKAIAARRATRPLHTTLELAECVASAVRTREKGQHPATRTFQALRIYINRELEELARALASAIELLVPGGRLAVISFHSLEDRMVKQCIAAAARPAAAHPRLPLRESELPQPILQTLGKVVADDAEVAGNARSRSAILRAAERTSQPLPATGAEDFVPAVPGAAEKGRRR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_YERE8
Sequence: MNTTHASMTVIGAGSYGTALAITLARNGHQVVLWGHDPKHIQTLQQDRCNQAFLPDVPFPDTLLLETDLARALAASRDVLVVVPSHVFGAVLNQLKPHLRPDARIVWATKGLEAETGRLLADVAREVLGESIPLAVVSGPTFAKELAAGLPTAIALASTDVQFSEDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMTRLGSALGADPSTFMGMAGLGDLVLTCTDNQSRNRRFGIMLGQGLGVQEAQDKIGQVVEGYRNTKEVLALAQRNGVEMPITEQIYQVLYSHKNAREAALTLLGRTKKDEKSGI
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFTA_MYCUA
Sequence: MDRETEAETAELVTESLVEEVSIDGMCGVY
What is the function of this protein?
Precursor peptide that leads to mycofactocin (MFT) after extensive post-translational modifications by enzymes encoded by adjacent genes.  Mycofactocin acts as a redox cofactor of nicotinamide-dependent oxidoreductases encoded in the same locus.
What are the official names of this protein?
Mycofactocin precursor peptide.
What is the protein family that this protein belongs to?
Belongs to the mycofactocin precursor peptide family.
Protein: Y514_METJA
Sequence: MITLIEIKKSLDEILSKIDGDKKYINEVAKKITPITYKLLYINETKCIRCNLCYKECPVDAIEKAKVKKSAKIIEDKCVKCEICAQTCPVGAIYVIEGRAEIEDSEVHYTIKEKSIPHRKIRLKKYELDENTCIKCGICARFCPTNAIKAVRRKSIEVNLDLCMGCGACAEVCPKKCIKVERELGEVIKTRDIEVDKNLCVGCLVCIEECPINAIDQDGDKVKINKDKCILCGRCVDVCPTNAIKMWEKK
What are the official names of this protein?
Uncharacterized polyferredoxin-like protein MJ0514.
Protein: SYH_THESQ
Sequence: MKYRRIKGTNDIFGEEIWYWRYVEETFRNVCESAGIEEIRTPIFEQTELFVRSVGEESDIVQKEMYTFQDKAGRSITLRPEGTAPVVRAFLENSLIDRGFQQRYYYIGPMFRYEKPQSGRLRQFHQVGFEIIGPESPKADFEVIMLVDTFLRRLGLTKYKIHLNSIGCPVCRKNYREALKEYYGQVLDNLCDDCKRRYETNILRLLDCKVDHEYSLNAPKSVDYLCDSCRAHYKKLKEYLNTFEIEYVEDHTLVRGLDYYTRTVFEVRHEGLGAQSAIAGGGRYDGLFAELGGSSVPALGFAGGIERIILALKAEGIEIPMKNVHLVYIATLGEKAFMDGVRLAGELRKKGLSVDVDIMDRKLSGQLKHASRMGSRYAVIIGDEELEKGIVILRDLETGDQVEIDRDFAADYIAERVSKD
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR8_JASNU
Sequence: MCRDTIAEILTSIRNAYMDRKRVVRIASTNITENIVKILFREGFIENVRKHREKNKSFLILNLQWNRKRLHKNLFSFKLKRISRPSLRIYSNSQRIPRIFGGMGIVILSTSRGIMTDREARLHGMGGEILCCIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSBB_NUPAD
Sequence: MGLPWYRVHTVVLNDPGRLLSVHIMHTALVSGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWSITGGTITNPGIWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLEIFCDERTGKPSLDLPKIFGIHLFLSGVACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQPISPSWGAEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKALRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVNAGLAENLSLSESWSKIPDKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPIFRDKEGHELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTVEFYGGELDGVSYNDPATVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGTFQKLGDPTTRRQVV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RBG4_ARATH
Sequence: MAFCNKLSGILRQGVSQSSNGPVTSMLGSLRYMSSKLFVGGLSWGTDDSSLKQAFTSFGEVTEATVIADRETGRSRGFGFVSFSCEDSANNAIKEMDGKELNGRQIRVNLATERSSAPRSSFGGGGGYGGGGGGGY
What is the function of this protein?
Possibly has a role in RNA transcription or processing during stress (PubMed:16207746).  Binds sequence non-specifically to RNAs and DNAs (PubMed:16207746).  Mediates cell-to-cell trafficking of RNA interference (RNAi) signals (small RNAs (sRNA), e. g.  small interfering RNA (siRNA) and microRNA (miRNA)) which regulate growth and development, as well as responses to environmental inputs, including pathogen attack; can compromise zucchini yellow mosaic virus (ZYMV) and tobacco rattle virus (TRV) infections at the early stage (PubMed:31812689).
What are the official names of this protein?
Glycine-rich RNA-binding protein 4, mitochondrial, AtGR-RBP4, AtRBG4, Glycine-rich protein 4, AtGRP4, Mitochondrial RNA-binding protein 1b, At-mRBP1b, Small RNA binding protein 4, AtSRBP4.
What is the protein family that this protein belongs to?
Belongs to the GR-RBP family.
What are the subcellular locations of this protein?
Mitochondrion. Secreted. Note=Observed in the phloem translocation stream.
Protein: TIF1A_MOUSE
Sequence: MEVAVEKAAAAAAPAGGPAAAAPSGENEAESRQGPDSESGGEASRLNLLDTCAVCHQNIQSRVPKLLPCLHSFCQRCLPAPQRYLMLTAPALGSAETPPPAPAPAPAPGSPAGGPSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKYTGNQIQNRIIEINQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNTTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQSSQPPGGLPSNQLSKFPTQISLAQLRLQHIQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQHPPPRLINFQNHSPKPNGPVLPPYPQQLRYSPSQNVPRQTTIKPNPLQMAFLAQQAIKQWQISSVQAPPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSLPDIDCSSTIMLDNIARKDTGVDHAQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNTNYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPGLHQENSSNGKSEWSDASQKSPVHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPTLTNFPSGEWICTFCRDLSKPEVDYDCDVPSHHSEKRKSEGLTKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLESYFEELLKNLYPEKRFPKVEFRHEAEDCKFSDDSDDDFVQPRKKRLKSTEDRQLLK
What is the function of this protein?
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes.  Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac).  Has E3 protein-ubiquitin ligase activity.  During the DNA damage response, participates in an autoregulatory feedback loop with TP53.  Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation.  After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (By similarity).  Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels.  Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1.  Modulates transcription activation by retinoic acid (RA) receptors, including RARA.  Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).  Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway.  Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (By similarity).
What are the official names of this protein?
Transcription intermediary factor 1-alpha, TIF1-alpha, E3 ubiquitin-protein ligase Trim24, RING-type E3 ubiquitin transferase TIF1-alpha, Tripartite motif-containing protein 24.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Detected in the cytoplasm of the zygote. Translocates into the pronucleus at the time of genome activation. Colocalizes with sites of active transcription.
Protein: RLMN_HELPS
Sequence: MKASIYDFTLKELSQLLKPSFRAKQLYLWLYAKYKTSFKDMQNNFSKDFIAYLEQEFTLRTIEITHVRESVDGSKKYLFKSLRDNHTFEAVLLKMKDKKIDEETNAILEGEKYTVCVSCQIGCQVGCAFCFTQKGGFVRNLKASEIIQQALLIKEDNNLPIEKALNIVFMGMGEPLNNLDEVCKAIEIFNTGMQISPKRITISTSGVADEIPILAGKNLGVQLAISLHAVDDKTRSSLMPLNKKYNIECVLNEVRKWPLEQRKRVMFEYLLIKDLNDSLDCAKKLLKLLNGIKSKVNLILFNPHEGSKFERPSLESARMFADFLNSKGLLCTIRESKALDIEAACGQLREKKLSQQI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA3_ARATH
Sequence: MNILNRLGLGSSGQTNMDPSPIAQGNDDDTPAPGNQFAQFGAGCFWGVELAFQRVPGVTQTEAGYTQGTVDNPSYGDVCSGTTGHSEVVRVQYDLNDCTYESLLDLFWSRHDPTTLNRQGNDVGTQYRSGIYFYTPEQEKLARESLERHQQQMERKIMTEILPAKKFYRAEEHHQQYLSKGGRFGQGQSTAKGCNDPIRCYG
What is the function of this protein?
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins.  Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation.  May prevent cellular oxidative damage due to light exposure.  MSRA family specifically reduces the MetSO S-enantiomer.
What are the official names of this protein?
Peptide methionine sulfoxide reductase A3, AtMSRA3, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase, Protein-methionine-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: SSB2_LACLA
Sequence: MINNVVLVGRITRDPELRYTPQNQAVATFSLAVNRQFKNANGEREADFINCVIWRQQAENLANWAKKGALIGVTGRIQTRNYENQQGQRVYVTEVVADSFQMLESRSAREGMGGGTSAGSYSAPSQSTNNTPRPQTNNNNATPNFGRDADPFGSSPMEISDDDLPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein 2, SSB 2.
Protein: NSUN3_MOUSE
Sequence: MLTRLKAKSEGKLAKQLCRVVLDQFDKQYSKELGDSWSTVRDVLISPSLWQYAILFNRFNYPFELEKALHLRGYHTVLQGALPHYPKSMKCYLSRTPDRMPSERHQTGSLKKYYLLNAASLLPVLALELRDGEAVLDLCAAPGGKSVALLQCAYPGYLLCNEYDRPRGRWLRQTLESFIPQPLINVIKVSELDGREMGDAQPATFDKVLVDAPCSNDRSWLFSSDSQKAAYRIHQRKNLPVLQVELVRSAIKALRPGGLLVYSTCTLSKAENQDVISEVLTSDSNIVPVDISGIARTFSQDFTFAPTDQKCSLLVIPEKGKAWGPMYIAKLKKGMSTRKRQGEFCKPC
What is the function of this protein?
Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met).  mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position.  mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation.
What are the official names of this protein?
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial, NOL1/NOP2/Sun domain family member 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PLSY_SALA4
Sequence: MSAIAPGMILFAYLCGSISSAILVCRIAGLPDPRESGSGNPGATNVLRIGGKGAAVAVLIFDILKGMLPVWGAYALGVTPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKLKKKRQKD
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SECB_SHESH
Sequence: MAEVANNEQQEPQFNIQRVYTKDISFETPNSPAVFQKEWNPEVKLDLDTRSAKLADNVFEVVLSLTVTAKNGEETAFLCEVQQAGIFAINGLTEQQLAHSLGAYCPNILFPYARETVGSLVGRGTFPQLNLAPVNFDALFAQYVNQRQEGAEEAAQTEEASA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPLA_BLOPB
Sequence: MCSLRLLLSDSYDPWFNLSLEEYIYKNIPKKQSILFLWRNQNTVVIGRAQNAWKECNTRRMERDGIKLARRNSGGGAVFHDLGNTCFTFISTQEHYDKSISSNIVLNGLSYIGIKAIISGRNDIVIRTENGEHRKISGSAYRETSGRKFHHGTLLLHVDIDKLDYYLNPDFKKLETKGITSIRSRVANLNELKPGINHQEVCLGLTEAFFQHYGMKVKPEILSTDNFCKIPEFFKQFNKQSDWNWNFGSAPAFTHQLDTRFDWGSVTLHCDIERGIIHRSHIFTDSLDPSPLEILAKKLVGIPYNNKSILCCCKEWMQSWPQYKKELSEVSHWLIKTIS
What is the function of this protein?
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
What are the official names of this protein?
Lipoate-protein ligase A, Lipoate--protein ligase.
What is the protein family that this protein belongs to?
Belongs to the LplA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSP1_STRMT
Sequence: MKNTVKLEQFVALKEKDLQKIKGGESRLPKIRFDFIFPRKK
What is the function of this protein?
Acts as a pheromone, induces cells to develop competence for genetic transformation.
What are the official names of this protein?
Competence-stimulating peptide, CSP.
What is the protein family that this protein belongs to?
Belongs to the ComC family.
What are the subcellular locations of this protein?
Secreted.