PharMolix/UniProtQA huggingface dataset:
Protein: TRM56_SULTO
Sequence: MHHRPERDKRVTTHVALVARAFGAKGIFIHGEDMNLLKTIEKVKANWGGKYFSIEFVKNPKKVVRDWRNSGGIVVHLTMYGIPIDNIMEKIINKNTKILVVVGSEKVEGWYYYNSDYNIAIGNQPHSEVAALAIFLDRIYKGGELNIQFSDAKLSIIPQERGKKVRKNE
What is the function of this protein?
Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
What are the official names of this protein?
tRNA (cytidine(56)-2'-O)-methyltransferase, tRNA ribose 2'-O-methyltransferase aTrm56.
What is the protein family that this protein belongs to?
Belongs to the aTrm56 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAZF3_MYCTU
Sequence: MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNTQTIPVCDLGRQIGYLLASQEPALAEAIGNAFDLDWVVA
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rRNA only cleaves once in the ribosomal A site in dissociated but not intact ribosomes.  Cleavage of 23S rRNA inhibits protein translation; the 23S rRNA region cleaved is involved in tRNA-binding in the A site, 30S and 50S subunit interaction and ribosome recycling factor association (PubMed:23650345).  Upon expression in E. coli and M. smegmatis inhibits cell growth and colony formation.  It dramatically increases persister cell formation in M. smegmatis upon challenge with gentamicin or kanamycin.  Overexpression leads to bacteriostasis rather than bacteriocide.  Its toxic effect is neutralized by coexpression with cognate antitoxin MazE3.
What are the official names of this protein?
Endoribonuclease MazF3, 23S rRNA endonuclease MazF3, Toxin MazF3, mRNA interferase MazF-mt6.
What is the protein family that this protein belongs to?
Belongs to the PemK/MazF family.
Protein: DHQS_KORCO
Sequence: MRSKELIILADSSPDSVVEKAIKMGLKVAAVDQSVKERLKGYLDPSLIVEVSEWPSEGELTLFKIRGPEDVEILRREANERKFLIESESWKIIPLENIIAEVGGERIYAIADDLEEARSLLGVLEIGVKGVVIPIKDSAQLERALRLSEEVNPLNLREARVTEVKQVGMGDRVCVDTTSILSKGEGMLVGGSASFLFLVHSENIESPFTSPREFRVNAGAVSNYLLAPGGKTLYLSEVRAGSEVLAVSVDGRRRAVSVGRAKVERRPMVLVRASSDGEEGWTVLQLAETIPLVKPDGSTVAVTDLKPGDRVLVYVSERKARHFGTAVDEFIEER
What is the function of this protein?
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
What are the official names of this protein?
3-dehydroquinate synthase, DHQ synthase, 3-dehydroquinate synthase II.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type DHQ synthase family.
Protein: TX14B_MYRGU
Sequence: MGKIFFFVLMIAIIGSTFLIEEALGSLVGCPRPNFLPSWNRCKCICKNNKPMCRKLPNLLKTTA
What is the function of this protein?
May have antimicrobial properties, like most ant linear peptides.
What are the official names of this protein?
U-myrmeciitoxin(01)-Mg4b, MIITX(01)-Mg4b, U-MIITX(01)-Mg4b.
What is the protein family that this protein belongs to?
Belongs to the ant myrmeciitoxin-01 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL7_STRA1
Sequence: MALNIENIIAEIKEATILELNDLVKAIEEEFGVTAAAPVAAAAASGEAAAAKDSFDVELTAAGDKKVGVIKVVREITGEGLKEAKAIVDNAPSVIKEGASEAEANEIKEKLEAAGASVTLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: SIRPG_HUMAN
Sequence: MPVPASWPHPPGPFLLLTLLLGLTEVAGEEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGPVLWFRGVGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISSITPADVGTYYCVKFRKGSPENVEFKSGPGTEMALGAKPSAPVVLGPAARTTPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPTGQSVAYSIRSTARVVLDPWDVRSQVICEVAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQPMRVGNQVNVTCQVRKFYPQSLQLTWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDDVVLTCQVKHDGQLAVSKRLALEVTVHQKDQSSDATPGPASSLTALLLIAVLLGPIYVPWKQKT
What is the function of this protein?
Probable immunoglobulin-like cell surface receptor.  On binding with CD47, mediates cell-cell adhesion.  Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
What are the official names of this protein?
Signal-regulatory protein gamma, SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-b2, SIRP-beta-2.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: MALK_PHOLU
Sequence: MSSVTLRNVSKAYGETIISKNINLEIQEGEF
What is the function of this protein?
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Maltose/maltodextrin import ATP-binding protein MalK.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RECN_RICBR
Sequence: MFHSLSVKNFILIDELEIEFTNGLCVITGETGAGKSILLDAILFCLGYKTSSAGIIKHGKDYAAVNIVFSLNDEIKNFLTQNFIELEESLLIKCVQKAEGRKNFFINNQVVNKAIMQQLATYLFELHGQNNNISLLEINTQRDILDSFGDLLELRMQLAKCYQAWQNIRNEIAEIALKQNSIEQEIDYLNFVTEELIKLNVQTGEEEQLTNIRKDLQNKDKDLQLIKDIFEQVNNPEINSSISKAEKLLAKQSQNEEFANISTNLEEAYNNLEEARQNLSNLLENFNKLDYNLEEIEERLFAIKAISRKYNVSADALKTFLEESLNRLNSLKGKIANQAELQVQEAKLSTEYYKLGKDLSGKRLAAAKRLEEVLHHELKQLKMEKATFHVNIAERKEAAAYGIDDIVFKASTNPGMSPEAINKIASGGELSRFMLALKTSLFNKMVKPAIIFDEIDVGIGGEVADKVGERLKKLSSATQVIVITHQPQVAGKADLHIKIEKTQLEKETKVTVKALNLAERQQELARMISGKAITEASLKAAKELLCHPVA
What is the function of this protein?
May be involved in recombinational repair of damaged DNA.
What are the official names of this protein?
DNA repair protein RecN, Recombination protein N.
What is the protein family that this protein belongs to?
Belongs to the RecN family.
Protein: CYBR1_XENTR
Sequence: MEGYKSFLVFLVSSLLLGFLGVIFTLVWVLHWREGLGWDGGAAEFNWHPVLVTSGFIFIQGIAIIVYRLPWTWNCSKLLMKFIHAGLHLTAFVFTIVALVAVFDFHNAKNIPNMYSLHSWIGLTVVILYALQLVLGVSIYLLPFARDTLRAALMPVHVYSGLLIFGTVIATALMGITEKLIFSLKEPPYSKMPPEAIFVNTFGLIILVFGGLVVWMVTTPAWKRPREQEIKALNPTVSSPDGTEEGSTITDCSNTEKSDVELNSEAARKRILKLDDAGQRSTM
What is the function of this protein?
Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+).  It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration (By similarity).  May also function as a cupric transmembrane reductase (By similarity).
What are the official names of this protein?
Plasma membrane ascorbate-dependent reductase CYBRD1, Cytochrome b reductase 1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Protein: ALF_MYCTU
Sequence: MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTH
What is the function of this protein?
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
What are the official names of this protein?
Fructose-bisphosphate aldolase, FBP aldolase, FBPA, Fructose-1,6-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family.
Protein: SLY1_ENCCU
Sequence: MLRELQKQRIKAFLVAPNNPWKILVLDSRTQQIIGPLMKVSELRECGITAHFLVTQERHPISNTPAVYFVESADGVLDDVLAELYSEYYLNFATSVTRGEIESLGLGLSERGLGLRIRSVYDQFVDFIALQDDMFTLGMKGSFIEMENPDTWRRMVMSVMSVFVTLGEVPFIVATDDDVTTQMARMLETKIRNTGVIKRGSKRPVLVLVSRSHDVITPVQHVWSYSALMNDLFALESNKITLKSGKVFDLDPQDELWRRNANEYFPVVVERVEKELLEYKKEMALRSIDEKTDKKVIQEALDKAPELAKRNESVNAHISICSEMVEMIKERAIDDFYKVEKGGHTNQELIELSEKGSDEDVLRLAILLLNTKDFDLIDPLLRKRKIKSKAIEFFRRHGGTRSEKLGTLYSQVVTSLMGNVKKLLPVKEQTPISSLVETIYGDIKSQIYSGLRVFDSMGSKSIYASEISRLVVFGVGGGTYTELKTLKLLEERIGVPIIYGSTEILNAREFLRQVEGRMSLD
What is the function of this protein?
Involved in vesicular transport between the endoplasmic reticulum and the Golgi.
What are the official names of this protein?
SEC1 family transport protein SLY1.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Protein: IF3_METPB
Sequence: MPAPQKDGPRANRDIRGVRDVQLIDQDGQNRGVVPFFDALAMAEEVGLDLVEIAPNSVPPVCKFLDYGRFRFNEQKKQNEARKRQKTVEVKEIKLRPGIDKHDYDVKMKAVQRFFEEGDKVKVTLRFRGREIAHQDIGLRLLERVKQETQEVAKVESEPMLEGRQMIMILAPR
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSK2_NEIMB
Sequence: MFWIVLIVILLLALAGLFFVRAQSEREWMREVSAWQEKKGEKQAELPEIKDGMPDFPELALMLFHAVKTAVYWLFVGVVRFCRNYLAHESEPDRPVPPASANRADVPTASDGYSDSGNGTEEAETEEAEAAEEEAADTEDIATAVIDNRRIPFDRSIAEGLMPSESEISPVRPVFKEITLEEATRALNSAALRETKKRYIDAFEKNETAVPKVRVSDTPMEGLQIIGLDDPVLQRTYSHMFDADKEAFSESADYGFEPYFEKQHPSAFSAVKAENARNAPFHRHAGQGKGQAEAKSPDVSQGQSVSDGTAVRDARRRVSVNLKEPNKATVSAEARISRLIPESQTVVGKRDVEMPSETENVFTETVSSVGYGGPVYDETADIHIEEPAAPDAWVVEPPEVPKVPMTAIDIQPPPPVSEIYNRTYEPPSGFEQVQRSRIAETDHLADDVLNGGWQEETAAIADDGSEGAAERSSGQYLSETEAFGHDSQAVCPFENVPSERPSCRVSDTEADEGAFPSEETGAVSEHLPTTDLLLPPLFNPEATQTEEELLENSITIEEKLAEFKVKVKVVDSYSGPVITRYEIEPDVGVRGNSVLNLEKDLARSLGVASIRVVETIPGKTCMGLELPNPKRQMIRLSEIFNSPEFAESKSKLTLALGQDITGQPVVTDLGKAPHLLVAGTTGSGKSVGVNAMILSMLFKAAPEDVRMIMIDPKMLELSIYEGIPHLLAPVVTDMKLAANALNWCVNEMEKRYRLMSFMGVRNLAGFNQKIAEAAARGEKIGNPFSLTPDDPEPLEKLPFIVVVVDEFADLMMTAGKKIEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRIAFQVSSKIDSRTILDQMGAENLLGQGDMLFLLPGTAYPQRVHGAFASDEEVHRVVEYLKQFGEPDYVDDILSGGGSEELPGIGRSGDDETDPMYDEAVSVVLKTRKASISGVQRALRIGYNRAARLIDQMEAEGIVSAPEHNGNRTILVPLDNA
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination.  FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation.  FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
What are the official names of this protein?
DNA translocase FtsK 2.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Note=Located at the septum.
Protein: LRC27_HUMAN
Sequence: MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRNPTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDLSELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKELPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRREKRALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDEVLKLKLGLTLNKDRRRAALTGNLSLGLPAAQPQNTFFNTKYGESGNVRRYQ
What are the official names of this protein?
Leucine-rich repeat-containing protein 27.
Protein: YUBF_BACSU
Sequence: MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGYYIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES
What are the official names of this protein?
Uncharacterized membrane protein YubF.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1196_FRATN
Sequence: MNFDMSKLMQQAQKMQEQMKKAQQERENMEVIGESGAGLVTVTMTGKYDVKSVSIDNSLMSEDKEILEDLIAAAVNSAVKKVEENSTASSDIHKMAKDAGIDLPSGINFPFK
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein FTN_1196.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL7_ECO45
Sequence: MSITKDQIIEAVAAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPVEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKALEEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: NOT1B_DANRE
Sequence: MAQVKSLAQSLYPCSSQRLEHQMKLQILKNSSVTCNDGTPAGYYIKESRGSRRWLVFLEGGWYCFSKHTCDSRYESMRRLMSSSNWPPTRTGTGILSPQPEENPHWWNANTVFVPYCSSDVWSGSTPKTDQRGHQGALN
What is the function of this protein?
Probable inactive palmitoleoyl-protein carboxylesterase.
What are the official names of this protein?
Inactive palmitoleoyl-protein carboxylesterase notum1b.
What is the protein family that this protein belongs to?
Belongs to the pectinacetylesterase family. Notum subfamily.
Protein: SSTT_SHEHH
Sequence: MKQKTSLFARLADGSLVLQILVGIVAGVILATVSKSGAESVAFLGELFVGALKAIAPILVFILVAASIANQKKNAKTNMRPIVILYLFGTFSAAVTAVLMSFLFPTTLALSLDAAQASPPEGIGEVIHTLLFQLVDNPVNAVLTGNYIGILAWGVGLGLALHHATDSTKQVFADVSHGVSQMVRFIIRLAPIGIFGLVSATFATTGFTAIAGYMHLLLVLLAAMAIMALIINPAIVYFKIRRNPYPLVFTCLRESGVTAFFTRSSAANIPVNMALCEKLKLHEDTYSVSIPLGATINMGGAAITITILTLAAANTMGIQVDLLTAILLSVVAGVSACGASGVAGGSLLLIPLACSLFGISNDVAMQVVAVGFIIGVIQDSAETGLNSSTDVIFTAAACEAAERKENA
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WECA_ECOLI
Sequence: MNLLTVSTDLISIFLFTTLFLFFARKVAKKVGLVDKPNFRKRHQGLIPLVGGISVYAGICFTFGIVDYYIPHASLYLACAGVLVFIGALDDRFDISVKIRATIQAAVGIVMMVFGKLYLSSLGYIFGSWEMVLGPFGYFLTLFAVWAAINAFNMVDGIDGLLGGLSCVSFAAIGMILWFDGQTSLAIWCFAMIAAILPYIMLNLGILGRRYKVFMGDAGSTLIGFTVIWILLETTQGKTHPISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLASIGVLAEYSHFVPEWVMLVLFLLAFFLYGYCIKRAWKVARFIKRVKRRLRRNRGGSPNLTK
What is the function of this protein?
Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).  It is the first lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis, and an acceptor for the addition of subsequent sugars to complete the biosynthesis of O-antigen lipopolysaccharide (LPS) in many E. coli O types.  The apparent affinity of WecA for the polyisoprenyl phosphate substrates increases with the polyisoprenyl chain length.  WecA is unable to utilize dolichyl phosphate (Dol-P).
What are the official names of this protein?
Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase, Undecaprenyl-phosphate GlcNAc-1-phosphate transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. WecA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to discrete regions in the plasma membrane.
Protein: DNAJ_PICTO
Sequence: MAKDYYAILGVDRNASQDDIKKAFRELAKKYHPDANPGNKEAEEKFKEIAEAYEVLSDPQKRKQYDETGTTDFNAGSGFNWQDFTHFDDINDIFNQFFGGNFGDTFFGGYTNQPDLDIYLRVNISLEDAYYGASKNVKYRRNAMCEHCSGTGAENKVLITCPTCHGSGQERITRGQGFFRMVTVTECRTCHGRGKIPQKPCTVCHGTGTVSKNEDISVNIPKGADTNLKLRLKNMGNSYGGVTGDLYIVLIVNNPPGIRRSGQDIYVEHTIDFPEAALGGEEEIKLFRESYNLKIPAGTQPGEILKIKGAGMPRINGHGSGDLNVIIKIEVPKHLTSRQKELLEEFRNEKKKSWFHF
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HNT2_YEAS6
Sequence: MNKPIYFSKFLVTEQVFYKSKYTYALVNLKPIVPGHVLIVPLRTTVLNLSDLTMPESQDYFKTLQLIHRFIKWQYKADSINVAIQDGPEAGQSVPHLHTHIIPRYKINNVGDLIYDKLDHWDGNGTLTDWQGRRDEYLGVGGRQARKNNSTSATVDGDELSQGPNVLKPDSQRKVRALTEMKKEAEDLQARLEEFVSSDPGLTQWL
What is the function of this protein?
Cleaves A-5'-PPP-5'A to yield AMP and ADP.  Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine.  Is most effective on dinucleoside triphosphates.  Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock (By similarity).
What are the official names of this protein?
Bis(5'-adenosyl)-triphosphatase, AP3A hydrolase, AP3Aase, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, Dinucleosidetriphosphatase, Hit family protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion.
Protein: ISPF_AGARV
Sequence: MRVGMGYDVHKLVEGRDLILGGVKVPHTLGLLGHSDADVLLHAIMDALLGAAALGDIGKHFPDTDPAYEGISSLKLLEHVRDLIAKKGYVIENIDATVIAQKPKLRPYIEQMEQNVADTLQIAKEQVNIKATTEEWLGFTGREEGIASQAICSLTGLYEASMQVGGGCSGCGGCQAD
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: GCSH_MYCSK
Sequence: MSEIPAELYYTDEHEWVLRTGDDTLRVGITDYAQAALGDVVFVQLPDVGAELTSGESFGEVESTKSVSDLYAPVSAKVLAVNGNLEASPDLVNSDPYGEGWLVDLQLDADDMEAALGGLLDADGYRGVVTE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: PYRG_BRUME
Sequence: MARYVFITGGVVSSLGKGIAAAALAALLQARGYRVRIRKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTGRPANQQDNITTGRIYRNIIEKERRGDYLGATVQVIPHVTDEIKNFVLEGNEDYDFVLCEIGGTVGDIEAMPFLEAIRQLGNELPRGTAVYIHLTLMPYIPAAGELKTKPTQHSVKELRSIGIAPDILLVRADREIPESERRKLSLFCNVRESAVIQALDVATIYDVPIAYHKEGLDSEVLSAFGIDPAPKPRMDRWEEVSHRLHNPEGEVTIAVVGKYTGLKDAYKSLIEALHHGGLANKVKVNLDWIEAEVFESEDPAPYLEKVHGILVPGGFGERGAEGKILAAKFARERKVPYFGICFGMQMACIEAARNLVGIEDASSSEFDPTREPVVGLMTEWLKGNMLEKRAAAGDLGGTMRLGAYEAVLKPDSKIAQIYGSTDIHERHRHRYEVNIDYKDRLEAAGLNFAGMSPDGVLPETVEYADHPWFIGVQYHPELKSRPFEPHPLFASFIEAAIEQSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: NMO_PSESP
Sequence: MSNSLLSLLNIELPIIQSPMVGVSTPRLAAAVSNAGGLGSIGIGASNVEQARAMLRETAALTDRPFNVNLFCHVPARADAAREAQWLAFLAPLFAEFESPAPAALREIYTSFVEDFAMLEMLLEEKPAVVSFHFGLPPQSSIDALKDAGIVLLACVTNLAEAQQAEHAGVHALVAQGYEAGGHRGVFDPQQDSEMGTFALVRVLTDACQLPVIAAGGIMDGAGIKAVMQLGASAAQLGTAFILCPESSANPAYRDALQGPRAHQTRVTSAISGRPARGMVNRNYIDLETNAPALPDYPIAYDANKALNAAAANKANTDFAVQWAGQGAPLARSMPAAALVNLLAAEMKA
What is the function of this protein?
Nitronate monooxygenase that uses molecular oxygen to catalyze the oxidative denitrification of alkyl nitronates.  Acts on propionate 3-nitronate (P3N), the presumed physiological substrate.  Is likely involved in the degradation of P3N, that allows Pseudomonas sp.  JS189 to grow on 3-nitropropionate/P3N as the sole source of nitrogen, carbon, and energy (PubMed:20382807).  Also probably functions in the detoxification of P3N, a metabolic poison produced by plants and fungi as a defense mechanism (By similarity).  Is not active against 3-nitropropionate, nor with neutral or nitronate forms of 1-nitropropane, 2-nitropropane, nitroethane, nitromethane, 1-nitropentane, and 2-nitroethanol (PubMed:20382807).
What are the official names of this protein?
Nitronate monooxygenase, NMO, Propionate 3-nitronate monooxygenase, P3N monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the nitronate monooxygenase family. NMO class I subfamily.