Protein: SPY_ARATH
Sequence: MVGLEDDTERERSPVVENGFSNGSRSSSSSAGVLSPSRKVTQGNDTLSYANILRARNKFADALALYEAMLEKDSKNVEAHIGKGICLQTQNKGNLAFDCFSEAIRLDPHNACALTHCGILHKEEGRLVEAAESYQKALMADASYKPAAECLAIVLTDLGTSLKLAGNTQEGIQKYYEALKIDPHYAPAYYNLGVVYSEMMQYDNALSCYEKAALERPMYAEAYCNMGVIYKNRGDLEMAITCYERCLAVSPNFEIAKNNMAIALTDLGTKVKLEGDVTQGVAYYKKALYYNWHYADAMYNLGVAYGEMLKFDMAIVFYELAFHFNPHCAEACNNLGVLYKDRDNLDKAVECYQMALSIKPNFAQSLNNLGVVYTVQGKMDAAASMIEKAILANPTYAEAFNNLGVLYRDAGNITMAIDAYEECLKIDPDSRNAGQNRLLAMNYINEGLDDKLFEAHRDWGWRFTRLHPQYTSWDNLKDPERPITIGYISPDFFTHSVSYFIEAPLTHHDYTKYKVVVYSAVVKADAKTYRFRDKVLKKGGVWKDIYGIDEKKIASMVREDKIDILVELTGHTANNKLGTMACRPAPVQVTWIGYPNTTGLPTVDYRITDSLADPPDTKQKQVEELVRLPDCFLCYTPSPEAGPVCPTPALSNGFVTFGSFNNLAKITPKVLQVWARILCAVPNSRLVVKCKPFCCDSIRQRFLTTLEQLGLESKRVDLLPLILFNHDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCVTMAGSVHAHNVGVSLLTKVGLGHLVAKNEDEYVQLSVDLASDVTALSKLRMSLRDLMAGSPVCNGPSFAVGLESAYRNMWKKYCKGEVPSLRRMEMLQKEVHDDPLISKDLGPSRVSVTGEATPSLKANGSAPVPSSLPTQSPQLSKRMDSTS
What is the function of this protein?
Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway and circadian clock.  OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine.  Probably acts by adding O-linked sugars to yet unknown proteins.  Acts as a repressor of GA signaling pathway to inhibit hypocotyl elongation.  Functions with GIGANTEA (GI) in pathways controlling flowering, circadian cotyledon movements and hypocotyl elongation.  Acts as a light-regulated promoter of elongation via its interaction with GI.  Acts as an activator of cytokinin signaling.  Required with SEC for gamete and seed development (PubMed:12136030).  Its OGT activity has been proved in vitro but not in vivo (Ref. 5, PubMed:11457967, PubMed:12136030, PubMed:15155885, PubMed:15608330, PubMed:8799194).  Possesses O-fucosyltransferase activity on specific serine and threonine residues (PubMed:28244988).  Mediates O-fucosylation of the DELLA protein RGA, a repressor of the GA signaling pathway (PubMed:28244988).  O-fucosylation enhances RGA activity by promoting RGA binding to key transcription factors in brassinosteroid and light-signaling pathways (PubMed:28244988).  Regulates root hair patterning upstream of the transcription factor WER, independently of DELLA proteins and GA signaling (PubMed:32928908).  Involved in abscisic acid (ABA) signaling partly through functional ABAR (PubMed:34712252).  Mediates O-fucosylation of CPN20 that may depress ABA responses during seed germination and seedling development (PubMed:34712252).  Involved in the modulation of the pace of the circadian clock by mediating O-fucosylation of APRR5, one of the core circadian clock components (PubMed:31899321).  O-fucosylation promotes APRR5 proteolysis (PubMed:31899321).
What are the official names of this protein?
Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY, GDP-fucose protein O-fucosyltransferase SPINDLY.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.