PharMolix/UniProtQA huggingface dataset:
Protein: CY169_POSPM
Sequence: MTVTAVNVLLSLGVAALAVAVWKAVVMVIQIATSPLRNIPGPPNSNWVYGNLKEIFAAENSVLHEGWVAKYGNTIKYKGWLSRNRLFTVDTRALNYILSHSNEYQKPALARYNLGEVLGEGLLIVEGEQHRQQRRIMNPAFGPAQIRELTEIFVEKAQKLCLFWRNEISKSGEPARIDVLNGLSKMTLDVIGLAGFNYEFDSLNIDGKPNELNQAFSVMFRSLEGFAIVFPLLKALIPPLRLIPDGRSRRIAKARKVMRRMGMELITKKKAEILRAAAGEKEKDNLQSRDLLTLLIKANLATDLPESHRLSDEDVLAQVPTFLVAGHETTSNATAWCLYALTQAPEVQQKLRDELWSIPTENPSMDELNELPYLEAVVRETMRVHAPVPSTIRVAMTDDVIPLDTPFVDVHGQVQDSIRVKKGDPIFIPILVINRSKALWGEDAFEFKPERWESVPDAVQHIPGVWANQMSFLGGPRACIGYRFSLIEMKALIFALVRAFEFELAVPPEEIIKKSTAVQRPLVRSEMVKGCQLPLLIKPYHTV
What is the function of this protein?
Cytochrome P450 monooxygenase that is able to use 7-ethoxycoumarin, carbazole, phenanthrene and trans-stilbene as substrates for oxidation.
What are the official names of this protein?
Cytochrome P450 monooxygenase 169.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LEUD_GLUOX
Sequence: MDKFTELTAIAAPMPTENIDTDQIIPARFLKTIQRTGLGKNAFAAQRYDADGNEKPDFVLNQEPYRHAEILITYDNLGCGSSREHAPWALLDFGIRCVIAPSFADIFFNNCFKNGILPIRLPREICDELMDDARQGANSRLTVDLERQVIVRPNGEGIPFDVDPFRRHMLLEGLDDIGQTMAHDAEITSFEHRPSRAWVPSITIGTVK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: DPO3_BACSU
Sequence: MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASKSWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCIEELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPDLQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQIKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFAREKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKRVELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKMIYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGEIIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNASFDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHRAIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGLKNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVEDIASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYLNDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQKVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKSIIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPECQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFSGEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLVQGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLLKLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTLGIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIGCRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKYMFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMEDINAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNSIPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSLF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2AZ_EMENI
Sequence: MPGGKGKSIGGKAGSKDSAGKAQKSHSAKAGLQFPCGRVKRFLKNNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPRINRALLLKVEQKKKKDA
What is the function of this protein?
Variant histone H2A which can replace H2A in some nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received.  Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins.  Required for the RNA polymerase II and spt15/TBP recruitment to the target genes.  Involved in chromosome stability (By similarity).
What are the official names of this protein?
Histone H2A.Z.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL24_CHLTA
Sequence: MKRRSVCVGDTVYVLAGNDKGKQGKVLRCLKDKVVVEGINVRVKNIKRSQENPKGKRINIEAPLHISNVRLSIDNQPARLFVKVREKGRELWNKHSDGSSSLYRSVRERKG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: GET1_ASPTN
Sequence: MLSLIWTVFFVHVAIYLINTIGASTIDGLLWLLYLKLPTSTSKCAQEQTRLKREVVQLKREMNNTSSQDEFAKWAKIRRRHDKTMEEYEKINKTLNAQKTSFDWSVKIARWLSTNGLKIFLQFWYSKTPVFALPQAWFPYYVEWVLSFPRAPMGSVSIQVWSNVCATAISVLAEIVTAAFMQMASRTAVPVAAEDKKEL
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
What are the official names of this protein?
Protein get1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL9_STRAW
Sequence: MKIILTHEVSGLGAAGDVVDVKDGYARNYLIPRNFAIRWTKGGEKDVEQIRRARKIHEIQTIEQANEIKARLEGVKVRLAVRSGDAGRLFGSVTPADVASAIKASGGPEVDKRRIELGSPIKTLGAHETSVRLHPEVAAKVNIEVVAA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RECO_ALKOO
Sequence: MLITTEGFILKNRKFGETDSILTIFTRKAGKITAIAKGARRPKSNLLAGIQPFCYSEFVLYKGKNMYTVSQCEAKEIFYPLREDLKRLSYASYLVELVEAVTTEGQTNHRLFNLFGKTLFLLKKSDIEINPIVRAFEIKLMNYLGYKPQLMSCVNCDSKETTAWKFSATEGGLLCSSCYSADLFAMKISNTAVKLAIFLLMKDITEVQKLKISDHLNEELKKILKQYILTHTNKYDFKSLEVAEKL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: LEUC_BIFAA
Sequence: MGTTLAEKVWADHLVRKGSDGAPDLLYIDLMLMHEVTSPQAFEGLRLAGRKPRHVDQLIATEDHNTPTVDIDRPNPDETSALQLSTLEKNCKDFGVRLCPLGDADQGVVHAFAPVLGLTQPGMTIVCGDSHTSTHGAFGAMAIGIGTSEVEHVMATQTLSLKPFKTMAVNIEGDLPKGVTAKDIILAIIAKIGTGGGQGHVIEYRGEAIKKLSMDARMTICNMSIEAGARAGMIAPDEVTFEYLKGRPHAPEGEMWDKAVEYWKTLKTDDDAVFDKEVTINAEDLEPYVTWGTNPGQGVKISGVVPDPASFNDETERSAAERAIAYMGLKPGMRIKDIAVDTVFIGSCTNGRLEDLRVAASIMKGHHKADNIHRVLVVPASSRVRLQAEKEGLDKIFKDFGAEWRNAGCSMCLGMNPDKMVARERSISTSNRNFEGRQGKGSRTHLASPAVAAATAIRGTICSPADL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RRF_LEUCK
Sequence: MAFDLTDAKSRMQGAQDALQRELTSIRTGRANPHILDRIEVEYYGAMTPLNQVASISVPEARVLLITPFDKTALEEIIRAINMSDLGLNPSSDGNIVRLMIPQMTEEGRKDLAKQVKAEAEKAKVSVRNVRRDAMDSVKKEKEMPEDDVRKAENDIQKLTDNNIKAIDDIASEKEKELLTI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPL13_HUMAN
Sequence: MSSLPVPYTLPVSLPVGSCVIITGTPILTFVKDPQLEVNFYTGMDEDSDIAFQFRLHFGHPAIMNSCVFGIWRYEEKCYYLPFEDGKPFELCIYVRHKEYKVMVNGQRIYNFAHRFPPASVKMLQVFRDISLTRVLISD
What is the function of this protein?
Binds beta-galactoside and lactose.  Strong inducer of T-cell apoptosis.
What are the official names of this protein?
Placental protein 13-like, Charcot-Leyden crystal protein 2, CLC2, Galectin-14, Gal-14.
What are the subcellular locations of this protein?
Nucleus.
Protein: COAX_BIFAA
Sequence: MLLMAVDIGNTNVVIGFIDDGRIAGTYRITTKANHTSDEYGLMITQFLALSGYKPADVDDVIISSVVPKVMHSFRASIVKFLDIDPMIVGPGIKTGLNIRMDNPQNMGADCIADCAGAYYEYGGPILVADFGTATTFNYVTADASVISGLITTGIRTAAAALWEGTAQLPEVEITRPKSILAKSTKPAMQAGLYYNFLGGIERTIAQFHKEIDEDFRVVATGGLSRVFADGTNMIDIYDPDLIFKGMWHIYDRNVR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABAH2_ORYSJ
Sequence: MAFLLFFVFVTAAVLCFVVPAFLLLCTSVQRRRDVGQGGGRDWQKKKKLRLPPGSMGWPYVGETLQLYSQDPNVFFASKQKRYGEIFKTNLLGCPCVMLASPEAARFVLVSQARLFKPTYPPSKERMIGPSALFFHQGEYHLRLRRLVQAALAPDSLRALVPDVDAAVAATLAAWSGGHVASTFHAMKKLSFDVGVVTIFGGRLGRRHREELRTNYSVVERGYNCFPNRFPGTLYHKAIQARKRLRAILSEIVAERRARGGGGGGGGDDLLGGLMRSRDDGTAGAVALLTDDQIADNVVGVLFAAQDTTASVLTWILKYLHDSPKLLEAVKAEQMAIYVANEGGKRPLTWTQTRSMTLTHQVILESLRMASIISFTFREAVADVEYKGFLIPKGWKVMPLFRNIHHNPDYFQDPQKFDPSRFKVAPRPSTFLPFGSGVHACPGNELAKLEMLVLVHRLVTAYRWEIVGASDEVEYSPFPVPRGGLNAKLWKQEAEEDMYMAMGTITAAGA
What is the function of this protein?
Involved in the oxidative degradation of abscisic acid.
What are the official names of this protein?
Abscisic acid 8'-hydroxylase 2, ABA 8'-hydroxylase 2, Cytochrome P450 707A6, OsABA8ox2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NEC2_ALHV1
Sequence: MASGKKLIDQLCSVVSSFLCPSISSLDIDRCAVGPHIFSRGSSQAICTVKLLHGEVYNLEFVYRYWAHILEKYNFPFSPTFIICNNGLAVTLKCYVSEPRDLSSRYGQATSMALDVNLQRNSFVVLSQDDFIKFKTPLVFAKDLDITNSMVVCRTYLTSSRNSLQFLVVKSKNPRRLENVLDMIKRAVEATGSNLPATREKPLPLEQTEQLESTLPSSGHLRVLQSTSLTGRCPSWGAACALLLLSLAVGLMAILAAKLMQWP
What is the function of this protein?
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell.  Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2.  Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space.  There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
What are the official names of this protein?
Nuclear egress protein 2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae NEC2 protein family.
What are the subcellular locations of this protein?
Host nucleus inner membrane; Single-pass membrane protein. Note=Localizes also at the transient membrane of perinuclear virions.
Protein: CBID_ALKMQ
Sequence: MERYIIKDGKKLRYGYTTGSCATAASKAAAQMLLQPGEVHEVDIDTPKGWSLKLKVEDIQRSHGAVSCAIIKDAGDDPDVTNKLAIYSKLIWRQDTKIEIHGGEGVGTVTRPGLQIPVGKPAINPIPLQMIEREVREVIGPGRGVDIVISVPKGQEVAKKTFNPKLGIQGGISILGTSGIVEPMSEEAMKDSLALELPMAKAEKIKTFVFVPGNYGRDMAREKYKIHDKNMIKISNFVGFMMDQSVIQNVERILIIGHIGKLVKVAGGIFHTHSKVADGRREILAAHLAALGASQQLVLRVLESNTTEEAVGLIQEKGFDRLFSHLADKITEKCVERTQGNIEIGTIIFSMEQGVLAHCSQAGRLLEILKSEGVKDE
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: GUF1_NEOFI
Sequence: MRGCLQLARWLSAAPKGTAASLTRAPFVLANAPRFFTSSASHAGSRSTATKPVSDLENRIAAIPIERYRNFCIVAHVDHGKSTLSDRLLELTGTIEPGSNKQVLDKLDVERERGITVKAQTCSMIYNHNGEDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGIQAQTVANFYLAFAQGLELIPVINKVDLPSAEPERALEQMKNSFELDTENAVMVSAKTGLNVEKLLPTVIEKIPAYGYFPVYLHKLFPLLTLTSPIGDCKKPLRMLLVDSWYDSYKGVICLVRIFDGEIRAGQQVVSFATGLKYYVGEVGIMYPNETPQSVLRAGQVGYIYFNPGMKRSKEAKIGDTFTRVGFEKAVEPLPGFEEPKSMVFVAAYPVDADHFEHLEDSINQLVLNDRSITVQKESSEALGAGFRLGFLGTLHCSVFEDRLRQEHGASIIITPPSVPVKIIWKDGKEEIITSPAKFPEDEELRSKVAEIQEPYVLATLTFPEEYLGKVIELCEANRGEQKSLEYFTATQVILKYELPLAQLVDDFFGKLKGSTKGYASLDYEESAWQTGNIVKLQLLVNKAPVDAVARIVHLSQVERLGRQWVTKFKEHVDRQLFEVVIQAAVGKKIIARETVKPYRKDVLAKLHASDVSRRRKLLEKQKEGRKRLRAVGNVVIEHKAFQAFLAK
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor guf1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase guf1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: METXA_CLAM3
Sequence: MTDAQIRSLIGRPPASGAWREGDPVADRLFASVGGVDLEAGGRIPSVRVAYETFGERDPDGGNAVLVLHALTGDSHLRGPAGPGQPTGGWWSGIVGPGLAIDTDRWFVVAPNMLGGCQGTTGPASLAPDGAEWGARFPFITIRDQVAVQAALADALGIDVWAAVVGGSMGGMQALEWGVGLPGRMRRLAILAAPAIASADQIALNSVQAEAIRMDPAYRDGDYFDAADGDGPHRGLALARRMALLNYRSPDELNQRFSRSWQSGISPMGDEGRYAVESYLDFHGNKFTRRFDATSYIRLIDAMSSHDVGRDRGGVEAALASVRAATLVVGIDSDRLFPVPDQRLVARHVPGSVDGGEVVVISSDYGHDGFLIENEAVGRALARLLDTPA
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OCE3_LEPPU
Sequence: MAFLKKSLFLVLFLGLVSLSICDEEKRQDEDDDDDDDEEKRGVIDIIKGAGKDLIAHAIGKLAEKV
What is the function of this protein?
Has antibacterial activity against Gram-negative bacterium E. coli ATCC 25922 (MIC=320 uM) but not against S. pneumoniae ATCC 700603, S. choleraesuis ATCC 14028 or Gram-positive bacterium S. aureus ATCC 29313.  Shows no hemolytic activity and no cytotoxicity.
What are the official names of this protein?
Ocellatin-PT3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Ocellatin subfamily.
Protein: SECM_YERPP
Sequence: MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPLNLSGVPDHAALANTSSSQSRQNHGTTNFNSLALLHDIHRRLSFSVDYWQQHALRTVIRHLSFALAPQAAYARVQEVAETERVAPSKIQQLALLDTLNALLTHEFKPPAIIRYTEQVERPVLSPYKPGLWLAQVQGIRAGPANLS
What is the function of this protein?
Regulates secA expression by translational coupling of the secM secA operon.  Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
What are the official names of this protein?
Secretion monitor.
What is the protein family that this protein belongs to?
Belongs to the SecM family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Protein: Y1314_MYCBO
Sequence: MTRYLARRLLNYLVLLALASFLTYCLTSLAFSPLESLMQRSPRPPQAVIDAKAHDLGLDRPILARYANWVSHAVRGDFGTTITGQPVGTELGRRIGVSLRLLVVGSVFGTVAGVVIGAWGAIRQYRLSDRVMTTLALLVLSTPTFVVANLLILGALRVNWAVGIQLFDYTGETSPGVAGGVWDRLGDRLQHLILPSLTLALAAAAGFSRYQRNAMLDVLGQDFIRTARAKGLTRRRALLKHGLRTALIPMATLFAYGVAGLVTGAVFVEKIFGWHGMGEWMVRGISTQDTNIVAAITVFSGAVVLLAGLLSDVIYAALDPRVRVS
What are the official names of this protein?
Putative peptide transport permease protein Mb1314c.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NEF_HV1B8
Sequence: MGGKWSKSSVVGWPAVRERMRRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIHHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPEKEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHMARELHPEYFKNC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: ENO_LEVBA
Sequence: MSIISDIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKSRFMGKGVTKAVDNVNNIIAKEIIGYDVTDQRAIDQAMIDLDGTPNKGKLGANAILGVSLAAARAAADELGQPLYNYLGGFNGHVLPTPMMNVINGGKHANNKVDFQEFMIMPVGAKSVTEAIRMGSETFHNLKNLLNEKGYSTAVGDEGGFAPDLKNNEEPFEILVEAIKNAGYVPGKDVAIAFDCASSEFYNADTKKYELVGDGKEYTAEEFVSLLESIVDKYPVVSIEDPLDENEWEDWQMATERLGKKVQLVGDDLFVTNTDYLAKGIKMGVGNSILIKLNQIGTLTETVEAVEMAKQAGYTAVISHRSGETEDTTIADLVVALNAGQIKTGSMSRGERIAKYNQLMRIEDQLGKTSEYKGIHSFYNLDEDARMAIVNK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: IF6_NEUCR
Sequence: MAVRAQFENSNEVGVFSTLTNSYALVAVGASENFYSVFEAELQDVIPICRTTIAGTRIIGRLTAGNRKGLLVPTTTSDQELQHLRNSLPDDVRIQRIEERLSALGNVIVCNDHTALIHPDLERETEEIIADVLGVEVFRQTIADNVLVGSYMALSNQGGLVHPKTSIQDQDELSSLLQVPLVAGSVNRGSNVIGGGMVVNDWMAVTGLDTTAPELSVIESVFRLGEGAAPGQINSSLKDTMVESFY
What is the function of this protein?
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm.  Is also involved in ribosome biogenesis.  Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.
What are the official names of this protein?
Eukaryotic translation initiation factor 6, eIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Protein: CENPH_HUMAN
Sequence: MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSMVDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKISRQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKNKQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQLEKNVDMM
What is the function of this protein?
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.  Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
What are the official names of this protein?
Centromere protein H, CENP-H, Interphase centromere complex protein 35.
What is the protein family that this protein belongs to?
Belongs to the CENP-H/MCM16 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.
Protein: PANB_BURPS
Sequence: MTYLQESSRPAVTVPKLQAMREAGEKIAMLTSYDASFAALLDRANVDVQLIGDSLGNVLQGQATTLPVTLDDIAYHTACVARAQPRGLVVADLPFGTYGTPADAFASAVKLMRAGAQMVKLEGGEWLAETVRFLVERAVPVCAHVGLTPQSVHAFGGFKVQGKTEAGAAQLLRDARAVEEAGAQLIVLEAVPTLVAAEVTRELSIPTIGIGAGAECSGQVLVLHDMLGVFPGKRPRFVKDFMQGQPSIFAAVEAYVRAVKDGSFPGPEHSF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_RICTY
Sequence: MALKNFNPITPSLRELVQVDKTNLWKGRPLKSLTKGMSKTGGRNQQGRITSWHRGGGHKKLYRVIDFKRKKIDIFAVVERIEYDPNRTAFIALIKYDDGEYSYILAPQKLSIGDRVISSQAADIKIGNCLPLKSIPIGTTLHNVEMKVGKGGQIARSAGTSVELVGKDSGYAQIKLRSGEFRLVPLDCKATIGSISNPDQKNINLGKAGRNRWLGWRPHVRGVAMNPIDHPHGGGEGKTSGGRHPVTPWGFSTKGKKTRKNKRTSKFIVKKRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.