PharMolix/UniProtQA huggingface dataset:
Protein: SOAT2_CHLAE
Sequence: MEPGGARLRLQRTEGPGGEREHQPCRDGNTETHRAPDLVKWTRHMEAVKAQLLEQAQGQLRELLDRAMWEAIQSYPSQDKPPPLPPPDSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARPGARGTWTLGAGLGCALLAAHALVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYIRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGAQARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQHTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQTTFWGLVTPRSWSCHT
What is the function of this protein?
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol.  Plays a role in lipoprotein assembly and dietary cholesterol absorption.  Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates.  May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
What are the official names of this protein?
Sterol O-acyltransferase 2, Acyl-coenzyme A:cholesterol acyltransferase 2, ACAT-2, Cholesterol acyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YQGF_BRUA4
Sequence: MAVVEIEEIPALLQSGQTIAGLDLGTKTIGLAVSDLGLSFAHPRPVIKRVKFSIDAQVLLKALDADKVGVIVIGLPMNMDGTSGPRVQATRAFVRTMQPLTDLPFVFWDERLSTVAAERALIGMDVSRGKRADRIDSAAASFILQGALDRLHSIRRSASDDYDAG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLB_BLOFL
Sequence: MTIFQKSFILLIIWNFSLFAFSDMKIEITHGINTAHPIAVIPFINNENITHELNNDNIEDIASIIAADLRNSGKFNTLPIAYLPYQPSKLTDIIPTFWEKLGINTVVLGAINIKNENYVISYQLIDTSNNPALVILDNQYEIEKKHLRYTAHTISDEIFEKLTGIKGVFCTRIAYILYTNNIKYAYELCTSDYDGHNQVSICRSSEPLMSPAWSPDGKKLAYVTFASGHSELIIQTLTNRSIDNIIQFPNHNGAPAWSPDGKKLAFSLSKTGSLNLYIMDLSSNNIQQITSNRYNNTEPSWFPDSQNLAYTSDQGGVPQVYKININNNRDSHRISWLNGSNQKPNISMDGTFMVMVNRNKGKQYISKLNFLTGEEETLTADSVLADTPSISPNGIMFMYSSIILNNSSSELYLDKKFTNIPDNNQSILSLASIDGKFKAHLNGSTGSIRFPTWSSLSCSY
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.  TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ESPG2_MYCTO
Sequence: MLTTTVDGLWVLQAVTGVEQTCPELGLRPLLPRLDTAERALRHPVAAELMAVGALDQAGNADPMVREWLTVLLRRDLGLLVTIGVPGGEPTRAAICRFATWWVVLERHGNLVRLYPAGTASDEAGAGELVVGQVERLCGVAEAAPLRPVTVDADELLHAVRDAGTLRSYLLSQRLDVDQLQMVTMAADPTRSAHATLVALQAGVGPEKSARILVGDSTVAIVDTAAGRICVESVTSGQRRYQVLSPGSRSDIGGAVQRLIRRLPAGDEWYSYRRVV
What is the function of this protein?
Specific chaperone for cognate PE/PPE proteins.  Plays an important role in preventing aggregation of PE/PPE dimers.
What are the official names of this protein?
ESX-2 secretion-associated protein EspG2.
What is the protein family that this protein belongs to?
Belongs to the EspG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNRHR_CANLF
Sequence: MASASPEQNQNHCSAVNNSNMLMQGNLPTLTLSGKIRVTVTFFLFLLSTIFNASFLLKLQKWTQKKEKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLAMKNNGKLGQSMIGLAWLLSGIFAGPQLYIFRMIHLADSSGQTEGFPQCVTHCSFPQWWHQAFYNFFTFSCLFIIPLFITLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLRTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRVSDPVNHFFFLFALLNPCFDPLIYGYFSL
What is the function of this protein?
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH).  This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NHAA_VIBC3
Sequence: MSDMIRDFFKMESAGGILLVIAAAIAMVIANSAMGEGYQAFLHTYVFGMSVSHWINDGLMAVFFLLIGLEVKRELLEGALKSRETAIFPAIAAVGGMLAPALIYVAFNFNDPAAIQGWAIPAATDIAFALGIMALLGKRVPVSLKVFLLALAIIDDLGVVVIIALFYSSDLSTIALTIGFIMTGVLFMLNAKHVTKLSIYLVAGLILWIAVLKSGVHATLAGVVIGFAIPLKGNKGEHSPLKHLEHALHPYVAFAILPVFAFANAGISLQGVSLAGLTSMLPLGVALGLFLGKPLGIFSFSWAAVKLGVAKLPEGINFKHIFAVSVLCGIGFTMSIFISSLAFGQANEAYDTYARLGILMGSTTAALLGYSLLRLSLPLKKA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYR_AZOVD
Sequence: MKDTIRQLIQQALTRLTDDGVLPAGLTPAIQVENTKDKSHGDFASNIAMMLAKPAGLKPRQLAEKLVAALPADASVSKVEIAGPGFLNFFQNSDALARRLEVALADERLGVRKHGDLQRVVVDLSSPNLAKEMHVGHLRSTIIGDAVARVLEFLGDVVIRQNHVGDWGTQFGMLLAHLEEKPASAESELADLEQFYRAAKKRFDESEAFADRARELVVRLQAGEPECLRLWQRFNAISLSHCQEVYERLGVRLTPDDIRGESAYNDELPGIVQALRDKGLLTESEGAQCVFLDEFRNAEGNPLPVIVQKAGGGYLYATTDLASMRYRSQVLKADRVLYFVDQRQALHFQMTFAVARRAGFVRDDTALEHMGFGTMNGADGRPFKTRDGGTVKLIDLLDEAEQRAYALVKGKNPELPEEELRHIARAVGIGAVKYADLSKHRTSDYSFNFELMLSFEGNTAPYLLYAYTRVASVFRKLGREIDEIDGSPAPEAGQELALAARLAQFGEVLGNVAEKGLPHLLCAYLYDLAGLFSSFYENCPILTADTPARQQSRLLLAALTGRTLRQGLELLGLEPLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_SHEPC
Sequence: MAISAAQVKELRDRTGAGMMDCKKALEETNGDMELAIDNMRKSGAAKAAKKAGNIAADGTILIKNGEGFAVLLEVNCQTDFVAKDANFLGFANSVLDVAAASKVALEDLKAQFEEARVALVAKIGENINVRRVEYIDGAKLASYRHGERIGVVVTGDADDETLKHIAMHVAASKPEYVNPEDVPADVVAREQALQIEISMNEGKPADIAEKMVVGRMKKFTGEISLTGQAYIMEPKKTVGEFLKEKGAKVTNFIRLEVGEGIEKKEEDFAAEVAAQIAASKKA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RING1_MOUSE
Sequence: MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPMPGSDQTATMSGGEGEPGEGEGDGEDVSSDSAPDSAPGPAPKRPRGAGAGASSVGTGGGAAGGACGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQETTEPGGPGGGASDTGGPDGGGGERGVAGGGEGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
What is the function of this protein?
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation.  H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.  Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.  Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RING1, Polycomb complex protein RING1, RING finger protein 1, RING-type E3 ubiquitin transferase RING1, Transcription repressor Ring1A.
What are the subcellular locations of this protein?
Nucleus speckle.
Protein: ECM2_HUMAN
Sequence: MKIAVLFCFFLLIIFQTDFGKNEEIPRKQRRKIYHRRLRKSSTSHKHRSNRQLGIQQTTVFTPVARLPIVNFDYSMEEKFESFSSFPGVESSYNVLPGKKGHCLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQTVIPEGECCPVCSATVSYSLLSGIALNDRNEFSGDSSEQREPTNLLHKQLPPPQVGMDRIVRKEALQSEEDEEVKEEDTEQKRETPESRNQGQLYSEGDSRGGDRKQRPGEERRLAHQQQRQGREEEEDEEEEGEEGEEDEEDEEDPVRGDMFRMPSRSPLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNIK
What is the function of this protein?
Promotes matrix assembly and cell adhesiveness.
What are the official names of this protein?
Extracellular matrix protein 2, Matrix glycoprotein SC1/ECM2.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: NOS1_MOUSE
Sequence: MEEHTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGTPTKAVDLSRQPSASKDQPLAVDRVPGPSNGPQHAQGRGQGAGSVSQANGVAIDPTMKNTKANLQDSGEQDELLKEIEPVLSILTGGGKAVNRGGPAKAEMKDTGIQVDRDLDGKLHKAPPLGGENDRVFNDLWGKGNVPVVLNNPYSENEQSPASGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEQICMGSIMLPSHHIRKSEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVEFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
What is the function of this protein?
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.  In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.  Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.  Isoform NNOS Mu may be an effector enzyme for the dystrophin complex.
What are the official names of this protein?
Nitric oxide synthase, brain, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS.
What is the protein family that this protein belongs to?
Belongs to the NOS family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
Protein: COQ4_PLACH
Sequence: MNNFAKIFQSNWIDLNKLGKLEIFLKTISGIYKAPNRTHLLAHAADISSFYAVKNIYEYMKNDDEGKVILKNKPLLIRQDIQFNELKKLPKNTLGYKYMEFLEAYKLHAHDREAAHFFDDINYSYILTRYRQIHDIGHVVYNLNISIESEAALKMIELIHTKLPITLLAILVAPFMTPLYRFQYIFKDKIPPNFLNPNFDYTYKDDYNYIDELSLKQYVYNLTEYFHIDKIDNNIFFQKLYKYYFDNLNNSNNIRGTIIYGYNNEDNNDIIFDDINNEYIFLKNPEKNYFLFKYKPRQTLLKQLYPWAYMAGMAATKPLHSIHIENWLKDIDLFRKTYNIIPLPDHLNLMSGIN
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial, Coenzyme Q biosynthesis protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: NAGD_ECOLI
Sequence: MTIKNVICDIDGVLMHDNVAVPGAAEFLHGIMDKGLPLVLLTNYPSQTGQDLANRFATAGVDVPDSVFYTSAMATADFLRRQEGKKAYVVGEGALIHELYKAGFTITDVNPDFVIVGETRSYNWDMMHKAAYFVANGARFIATNPDTHGRGFYPACGALCAGIEKISGRKPFYVGKPSPWIIRAALNKMQAHSEETVIVGDNLRTDILAGFQAGLETILVLSGVSSLDDIDSMPFRPSWIYPSVAEIDVI
What is the function of this protein?
Catalyzes the dephosphorylation of an unusually broad range of substrate including deoxyribo- and ribonucleoside tri-, di-, and monophosphates, as well as polyphosphate and glucose-1-P (Glu1P).
What are the official names of this protein?
Ribonucleotide monophosphatase NagD.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. NagD family.
Protein: CPGP1_ZINOF
Sequence: DVLPDSIDWREKGAVVPVKNQGGCGSCWAFDAIAAVEGINQIVTGDLISLSEQQLVDCSTRNHGCEGGWPYRAFQYIINNGGINSEEHYPYTGTNGTCDTKENAHVVSIDSYRNVPSNDEKSLQKAVANQPVSVTMDAAGRDFQLYRNGIFTGSCNISANHYRTVGGRETENDKDYWTVKNSWGKNWGESGYIRVERNIAESSGKCGIAISPSYPIKEXXX
What is the function of this protein?
Cysteine proteinase with a high level of diversity in substrate specificity, an amino acid bearing a proline residue at the P2 position is preferred.
What are the official names of this protein?
Zingipain-1, Cysteine proteinase GP-I.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: GLYA_CHLPM
Sequence: MDTDILKMQDREVFEAIALETGRQMETLELIASENFTSRAVMQACGSVMTNKYAEGYPGKRYYGGCEFVDIAENLARDRAKKLFGCEYVNVQPHSGSSANMAVLFSVLKPGDCIMGLDLSHGGHLTHGSSVNFSGQMYKAHAYGVDGETGIIDMNQVEKMALEVRPRLIICGASAYSQGFDFKAFREIADKVGAFLMADIAHPAGLIVSGLLSDPMPHCHFVTTTTHKTLRGPRGGMIMMGKDFENPMGITIKTKNGQRVKMMSEVMDAEVMPGIQGGPLMHIIAGKAVAFGEALRPEFRQYAMQVRSNAAAMSERFLSLGYNIVSGGTKNHLMLLDLRNKDITGKVVENTLHEAGITVNKNMVPFDDKSPFVTSGIRIGTAAMTTRGMNEDDSRLIAELIDRVILSAASPESSSVCRSVKEEIRSLCLRNPLEGYGVTPS
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRRM1_HUMAN
Sequence: MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRKAQVSPQS
What is the function of this protein?
Part of pre- and post-splicing multiprotein mRNP complexes.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).  Involved in numerous pre-mRNA processing events.  Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome.  Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex.  Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions.  Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
What are the official names of this protein?
Serine/arginine repetitive matrix protein 1, SR-related nuclear matrix protein of 160 kDa, SRm160, Ser/Arg-related nuclear matrix protein.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus matrix. Nucleus speckle.
Protein: PANB_KLEP7
Sequence: MKPTTIALLQKCKQEKKRFATITAYDHSFAKLFADEGINVLLVGDSLGMTVQGHDSTLPVTVEDIAYHTRAVRRGAPNSLLLADLPFMAYATPEQTFANAAIVMRAGANMVKLEGGAWLADTVRMLAERAVPVCGHLGLTPQSVNVFGGYKVQGRGDAAQTLFEDALALEAAGAQLLVLECVPVELAKRITDALTIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAEAGDIRAAVRQYIAEVESGVYPGEEHSFH
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYNS_POPTR
Sequence: MEDNKTTIINRLEAVKRNSGKSCSQIAEQTGLTNVYVAQLLRRQAQLNPDTAPSLRAALPELPEDLLQEMMRPPMRSYDPNLIQEPCVYRLNEAVMHFGESIKEIINEEFGDGIMSAIDFYCSVDKVKGVDGKDRVVVTFDGKYLPYTEQKSEHMVSRPRPH
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: RL7_PARPJ
Sequence: MAIAKEDILEAVSSMSVLELNELVKAFEEKFGVSAAAVAVAGPAGGGAAAAAEEQTEFTVNLTEVGANKVSVIKAVRELTGLGLKEAKDLVDGAPKPVKESVPKAAAEEAKKKLEEAGAKAEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: SKL2_ARATH
Sequence: MAAFASGLAIIFNSPSLNPVTTQATFLSSNRIRSSPRVFSGFHSLRRRGFRRFSQNVIPDRFNSFSCNCLSAVSTSTIDYEFTDGGKEVELRLRLKTGEILSPKDISVDADGTSLAVKEKRNGLLITLLETNHLFEKIMPSETIWYIDEDQLVVNMKKVDGELKWPDIVESWESLTAGMMQLLKGASIYIVGDSTEINQKVSRELAVGLGYSPLDSKELLESFSKQTIDSWILAEGPDSVAEAESSVLESLSSHVRTVVSTLGGKHGAAGRADQWRHLYSGFTVWVSQTEATDEESAKEEARRSKQEREIGYSNADVVVKLQGWDPTHAKSVAQASLSALKQLIISDKGLPGKKSLYIRLGCRGDWPNIKPPGWDPSSDTGPHPQFT
What are the official names of this protein?
Probable inactive shikimate kinase like 2, chloroplastic, AtSKL2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: THIG_PECAS
Sequence: MLHIADTILTSRLLTGTGKFATPELMLAALEASGSQLVTMAMKRVDLNGGNDAILAPLRQLGIKLLPNTSGAKTADEAVFAARLAREALGTHWLKLEIHPDVKYLLPDPIETLKAAEQLVKEGFTVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLQTRDFLRIIIEQARIPVIVDAGIGAPSHAADALEMGADGVLVNTAIAVARDPVAMARAFRLAVNAGGLARQAGQGNKQFVASATSPLTGFLHQQTEGAER
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL117_HCMVM
Sequence: MVMFSQDHVQIVYGSTRICKSLAPANKRKTHRTIVVAPRRGFLRIPPDGQDVNHVKIVPTTTSSSLAPPRDDERRPTPPLRPPLTVYPYGTSLIRRSARDAKLRSKLIVFHITRPALGQHPQNPGISGPAAMDHSEFLTSFRREVDRQTVLTAESAPATVEVCLGDALPGGVMGGGGLPAGVGSASAAVAAAAAAVAGVPVAANPVMPATATVTTPPMIDLTSHHRPLTLFTPASAAAAPAVATNGGNATYILPADCRYAPLFASKYKYVFEEVSRLMRLHDSTAVQLQISASCGNAFQALKSALLKLHNVTVLAGQQLITQTMPHTPQAVATFKFFHQDPNRVLDCIRPVVPRSTSYHETGVYQMWVSGATKKDLFDAVTLCASIVEKQPDVFNINVSLLTYPSIAAPHLPLYNEFTSFRLPTS
What is the function of this protein?
Plays a role in the inhibition of host DNA replication in the infected cell.  Targets the mini-chromosome maintenance (MCM) complex and blocks the accumulation of MCM proteins and their loading onto host chromatin (By similarity).
What are the official names of this protein?
Protein UL117, pUL117.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae U84 family.
What are the subcellular locations of this protein?
[Isoform UL117]: Host nucleus. Note=The major fraction localizes to nuclear compartments. SUBCELLULAR LOCATION: [Isoform UL117.5]: Host nucleus.
Protein: RL6_CLOBA
Sequence: MSRVGRLPIAVPAGITVTVTPDNVVTVKGPKGELVKTMHKDINIAVENNEVIVTRPSDQKAHRALHGLTRALINNMVIGVNEGYQKTLELVGVGYRAQLQGKKLVMNLGYSHPVEIEPIDGITFETPAATKVIVKGIDKEKVGAAAADIRKWRLPEPYKGKGIKFENEVIRRKEGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NHAB_ECO7I
Sequence: MEISWGRALWRNFLGQSPDWYKLALIIFLILNPLIFIISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMTSAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCMAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLICGLLTCLLVEKLRCFGYGETLPEKVREVLQQFDDQSRQQRTRQDKIRLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIHFVLQASEHAQLSLFYIFNGLLSSISDNVFVGTIYINEAKAAMESGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTLVLTVVGLLCVEFTLAPVTEWFMQMGWIATL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.