PharMolix/UniProtQA huggingface dataset:
Protein: MUTS_SYNC1
Sequence: MTKLTPMMRQYLDIKAQYPDAILFFRLGDFYEMFMEDAVTASRILDITLTSRNKGAAEEVPLCGIPYHSCQPYVARLVEAGHKVAICEQVEDPKTVKGIVKREVVRVVTPGLVVDADTLTPKENNFLAAIAVSAQERYGIAVLDITTGEFRVTEVEGREAACSEVVSLQPREILVSEDQQQFCEQLLQGASGSWLINPLPDWVCDLEACGQRLQSFFNCGSLESFGCARLPEAVRAAGGVVYYVEQTQKGVAGHIRPLVTYHSRDYMVLDNSTRRNLELTATLQDGGRKGSLLGVLDRTVTAMGGRKIRQWIHHPLVDLKAIRDRHLSVQELVGQSLVRGDLRADLDGVYDLERLNSKIAMGHANAKDLVALRKSFEKLPRILQHLDELSAPLAAGIGSRIDPLTDMAELIGRAIVEDPPFVLREGGLMCDGYHLELDELRDIRRNGKEWIAKLEADERERTGIGSLKVRFNKVFGYYIEVTRTHLGRVPEDYQRKQTLANAERFFTPQLKEYEEKVLGAEDRLFDLEFELFQDLRERVAEQGERVQRTAEALAELDVLLSLADVAHSCDYVCPTMDDSDRLVIRDGRHPVIEAMNLGEHFVPNDVEMDCRENQIMVITGPNMAGKSTYMRQVALITLMAHMGSLVPAASAHIGLVDRIFTRVGASDNLAQGQSTFMVEMTEAAHILNHATSRSLIVLDEIGRGTSTFDGISIAWAVAEYLHDNGHVAAKTLFATHYHELTDLILTCERVKNLNIAVREWNEQIIFLRKIVKGPASHSYGIQVARLAGLPVAVIDRAKEILVNLESGELAEEGQPRLAQRAGGGQHRPNPQMSLFDAAADPVREKLAALDISTISPLEGLNFLHELQKLV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: URE32_BRUSU
Sequence: MHLTPREFDKLVIHMLSDVALKRKNKGLKLNHPEAVAVLSAYVLDGAREGKTVEEVMDGARSVLKADDVMDGVPDLLPLIQVEAVFSDGSRLVSLHNPIT
What is the function of this protein?
Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when inoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.
What are the official names of this protein?
Urease subunit gamma 2, Urea amidohydrolase subunit gamma 2.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APC11_YEAST
Sequence: MKVKINEVHSVFAWSWHIPSTSDEDAANNDPIGNDEDEDVCGICRASYNGTCPSCKFPGDQCPLVIGLCHHNFHDHCIYRWLDTPTSKGLCPMCRQTFQLQKGLAINDAHVQKFVEIVSRRREEMIEEGVAEEFVDFDEPIRQNTDNPIGRQQVDTILDEDFLLR
What is the function of this protein?
Probably catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.  In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition.  In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.  APC11 is required to recruit the ubiquitin-conjugating enzyme E2 to the APC/C.
What are the official names of this protein?
Anaphase-promoting complex subunit 11.
Protein: NU2C1_POPTR
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFDGSFIFPECILIFGLILLLMIDSTSDQKDMPWLYFISSTSLVMSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATTKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMIVGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNGGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLHLFWCGWQAGLYFLVSIGLLTSVLSIYYYLKIIKLLMTGQNQEITPHVRNYRGSPLRSNNSIELSMIVCVIASTIPGISMSPIIEIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 A, chloroplastic, NAD(P)H dehydrogenase, subunit 2 A, NADH-plastoquinone oxidoreductase subunit 2 A.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CH603_RHILE
Sequence: MSAKEIRFSNDARDRLLRGVELLNNAVKVTLGPKGRNVVIDKAYGAPRITKDGVSVAKEIELADKFENMGAQMVREVASKTNDLAGDGTTTATVLAASIFREGAKLVAAGMNPMDLRRGIDLGVTAVVKEIKARAMKVKSSSEIAQVGTIAANGDAAIGEMIAKAMDKVGNEGVITVEEARTAETELDVVEGMQFDRGYLSPYFVTNAEKMRVELEDPYILVHEKKLGSLQAMLPILEAVVQTGKPLLLISEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAVLTSGQMISEDLGIKLDNVTLDMLGHAKRVLIDKESTTIIDGSGEKAAIQARIQQIKAQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGATETEVKEKKDRIDDALNATRAAVEEGIVPGGGVALLRAKSALTGLTGENADVTAGISIVLRALEAPIRQIADNAGFEGSIVVGKLAGSNNHNQGFDAQTETYVDMIEAGIVDPAKVVRTALQDAGSIAALLITAEVMIADIPARDSAPAAGNGGMGDMGY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 3, 60 kDa chaperonin 3, Chaperonin-60 3, Cpn60 3.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1979_PYRFU
Sequence: MYRIKDEWGEFLVRLARRAIEEYLRTGREIEPPKDIPPELWEKMGVFVTLNRHNVPPQAALRGCIGFPLPIYPLVKATIKAAIYAAVDDPRFPPVKLEEMNNIVVEVSVLTPPELIEGPPEERPKKIKVGRDGLIVEKGIYTGLLLPQVAVEWGWDEEEFLAETCWKAGLPPDCWLDEDTKVYKFTAEIFEEEYPRGPVKRKPLIPQSQD
What are the official names of this protein?
Protein PF1979.
Protein: IPPK_DANRE
Sequence: MELDKMDENDWKYHGEGNKSIVVSHLRHCQVLRLLKVPSEDSAHTRQTAEQTLRHILNIMDYSKHVMKPLLGEKYVHSGEVVRLPLDFLRQMSLKVQQERPELRCDKVMDTFSGCGLCLPDLTQLPLHHLRDHRPPICVEIKPKCGFLPFSRHMTKECKWKVCRFCMHQHYKLANGKWKRLSRYCPLDLFSGSKQRMYVALKNLLEEPQNNLKIFKGGELIFSCKDDAKQQPDLNNLIQHLRPYFPHTNGLYNGHQPGKVILNEFIQVICSALLSGGDSNRSGEPRKMHLSESKPHCEASPFPRDLIRNGHHGLPKDSVLAKILQVQMLDNLDIEGIYPLYKRVEQYLEEFPKERIRLQIDGPYDESFMDTVKSCLNEDDGSVEYAIGKVHQYRVAMTAKDCSVMITFAPCEEDEEHKLNLEKPRFTYSVSILDLDTKPYEGIPHQYKLDSKIVNYYLRSTQAPPPSSLYKERQECTLLFHAV
What is the function of this protein?
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).  InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis and ion channel regulation.  InsP6 also acts as a key regulator of left-right asymmetry in embryo, probably by regulating asymmetric Ca(2+) during left-right specification.
What are the official names of this protein?
Inositol-pentakisphosphate 2-kinase, Inositol-1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase, InsP5 2-kinase.
What is the protein family that this protein belongs to?
Belongs to the IPK1 type 2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MNME_OCEIH
Sequence: MLDTDTITAISTPVGEGAIAIVRLSGSEAITITSQIFEGKNLQEVPSHTIQYGKIIDPGTNEVAEEVMVSIMRGPKTFTREDVVEINCHGGMVAVNRVLEIVLAKGVRLAEPGEFTKRAFLHGRIDLSQAEAVMDLIRAKTDKAMSVALKQMDGRLSKLIQKLRQELLETVAHVEVNIDYPEYDDVEEMSHAMMKEKSKEVRDELDKLLQIAQQGKILREGLSTAIIGRPNVGKSSLMNTLVQENKAIVTEIPGTTRDIIEEYVNVRGVPLRLVDTAGIRETEDIVERIGVDRSRQVLKESDLILFVLNYNEPLSEDDKKLFEAVDGLEYIVIINKTDLEQQLDLDEVREFAKDRPVVTTALLEEQGVDELEKAIADTFFTGDIDTGDMTYVSNVRHIQLLKQAKQALEDAMEGIELGMPMDIVQIDVTRSWEFMGEIIGDTASDSLIDQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_XANOR
Sequence: MSPFSIVLIGFAMSTDAFAAAIGKGAAMRKPQWRDALRAGLIFGCIEAITPVIGWVLGRAASSYLSAYDHWIAFVLLGALGTHMMIAGLRNGPDDANDAEAKTPKRHGLLGLATTGFATSIDAMAVGVSLAFLDVHIGVVAVVVGLCTFSMVTAGVMLGRALGNLIGKRAEILGGLILVIVGSVILYEHLGAAT
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPF_FRATO
Sequence: MSFRIGHGYDVHKFTSAKQNIIIGGVEIAYHLGLEAHSDGDVLIHALCDAIIGALGLGDIGKHFLDTDNQFKNIDSKFFLAEIKKMLDEKQYSISNIDCTIIAQAPKMLPHIEKMRACLANILEIQISQINIKATTTERLGFIGREEGIATHVVCLLYR
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: APT_CERSK
Sequence: MTHKSVRDYIRTIVDFPHEGILFRDVTTLFADPRGFRIAIDQLLAPYAGMRFDKVAGLEARGFILGGAVAHQLSTGFVPIRKKGKLPGRTISVSYQLEYGEAVVEVHDDAIQAGEKVLLVDDLLATGGTAEAGIKLIEQLGGQVVGCAFVVDLPDLGGRKRLEAMGMEVHALCAFEGL
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G137B_MOUSE
Sequence: MEAPPWEPVRNDSLPPTLSPAVPPYVKLGLTAVYTVFYALLFVFIYAQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFRDFVAANSFSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLVFLLVNLTCAVLVKTGDWDRKVIVSVRVAINDTLFVLCAISLSICLYKISKMSLANIYLESKGSSVCQVTAIGVTVILLYTSRACYNLFILSFSQIKNVHSFDYDWYNVSDQADLKSQLGDAGYVVFGVVLFVWELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQGLQGSFAPDYCDWGQQNNSFLAQAGTLHQDSTLDPDKASQG
What is the function of this protein?
Acts also as a negative regulator of osteoclast activity (PubMed:31173907).  Involved in interleukin-4-induced M2 macrophage polarization (PubMed:30595385).
What are the official names of this protein?
Integral membrane protein GPR137B, Transmembrane 7 superfamily member 1 protein.
What is the protein family that this protein belongs to?
Belongs to the GPR137 family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Note=Colocalized with MTOR in lysosome after amino acid stimulation.
Protein: PCDG6_PANTR
Sequence: MAPPQRHPQRSEQVLLLTLLGTLWGAAAAQIRYSIPEELEKGSFVGNIVKDLGLEPQELAEHGVRIVSRGRMQLFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSYFSVDVQSEAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSIAQILVTVLDVNDNTPVFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADRIPDILADLGSLEPSAKPNDSDLTLYLVVAVAAVSCVFLAFVIVLLALRLQRWHKSRLLQASGGGLASMPGSHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLINQESYEKSEPLLITQDLLETKGDPRQLQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin gamma-A6, PCDH-gamma-A6.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RLMN_ECO7I
Sequence: MSEQLVTPENVTTKDGKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2045_ALKPO
Sequence: MSADWSYLREKSASRLAPSMAKDHPNLPVVKEEGCYYYGVDGVKYLDFTSGIAVTNVGHRHPKIVQAIKEAADHLTHGPIGVIQYESILKLADELADILPGDLDCFFFANSGTEAIEGALKLAKFVTKRPYVVSFTGCFHGRTQGSLGVSTSKSKYRKFLQPNGLTYQVPYFKPSDPRILDEEGEVVESLACELLEEEFTNLFKYHVSSEEVAAVILEPVLGEGGYIIPPASWLAKVREICNRHDILLIFDEVQTGFGRTGEWFAAQTFGVTPDIMAIAKGIASGLPLSATVANHKLMQQWPLGSHGTTFGGNPIACSAALATLDVLKEENLLDNAREVGAYARERLNLLKEKYEMIGSIRSVGLMIGIEIIDPQTKKPDGAAVLRILDLALQEGVLFYLCGNEGEVIRMIPPLSVTKEQIDDGLDMLQRALVKYKEETHQPASL
What are the official names of this protein?
Uncharacterized aminotransferase BpOF4_10225, ORF B.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: GLMM_YERPS
Sequence: MSNRKYFGTDGIRGKVGESPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSALFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDDVEEAIEAEMEKPLTCVESAELGKANRIVDAAGRYIEFCKGTFPSELSLNELKIVVDCANGATYHIAPSVLRELGATVITIGCEPDGMNINEECGATDVRLLQERVLAEGAHVGLAFDGDGDRLMMVDHLGNKVDGDQILYIIAREGLRQGQLKGGAVGTLMSNMGLQLALKDLGIPFVRAKVGDRYVLEAMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLTAMVRNHMSLHDLCSGMKLLPQILVNVRFSGEHNPLKSDEVEEVTRQVEKELGGRGRVLLRKSGTEPLIRVMVEGDAEESLIAEMANRIADAVKAAG
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: KAPR_YARLI
Sequence: MTLPPAYVDELNLLNREVTTKQPTDILRFCADYFNERLAKREEADDDGPRSKPLGGGFREPGFGSSSRSTDGSLFRSSFADTSSEGPGSASSEPAAPFTRRTSVSAESIAPGAFAGAASGVASNNLSAEQLESLYKSVSHNFLFGNLDEEACRSVLQSLQEKKCDSGEKIITQGDEGDYFYIVESGAVEFIKDGVKVNSSGPGSSFGELALMYNAPRAATVVATQPCVLWSLDRVTFRKILLDGTHQRRSMYDGFLKEVPILSDLGSYERNKLADALTSQVVEPGTAVITEGEAGDAFYLVESGEAEVTKKGESGVVATLKQGDYFGEVALLNDLPRQATVTAKTKLKVATLGKDGFQRLLGPVLDHLKENDPTK
What are the official names of this protein?
cAMP-dependent protein kinase regulatory subunit, PKA regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the cAMP-dependent kinase regulatory chain family.
Protein: YMDB_CITK8
Sequence: MKSRIHVQHGDITQLTVDVIVNAANASLLGGGGVDGAIHRAAGPTLLEACKKVRQQQGECPAGHAVITLAGNLPAKAVIHTVGPVWRGGDHNESQLLEDAYFNSLQLVLANGYRSVAFPAISTGAYGYPRPAAAEIAVNTVADFLARHALPEQVYFVCYDEETARLYERLLTQQGDE
What is the function of this protein?
Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate.  Down-regulates ribonuclease 3 (RNase III) activity.  Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
What are the official names of this protein?
O-acetyl-ADP-ribose deacetylase, Regulator of RNase III activity.
What is the protein family that this protein belongs to?
Belongs to the YmdB family.
Protein: MED26_XENLA
Sequence: MTAAPVSPREIRERLLQAIDKQSNIQNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTSNEDLAKRAKKLLRNWQKLIEPVTQNEQLVRGIPNLPGSANGGGSHNCKADPAPTNLLAGKPIQELKGRNDIQKAHSPKADKTPKRKRKEHRDGGQGTPGHLSKPNHELFQNSSPPPTNGIGGSPPDNLPSPLDGGLQSNNRLEPAENDKHGKIPINAVRPHTNSPGLVKHPSTSSLLKVVVLQQHSGGLDDALSHQPRSPRCSSFSPRGTRAELATRQHTTYAPKGSAPSPSQRLPGVDSAHQSPLHPSTPPATAKRLESPRQDRVSSPHKPVEQLPSTDCHQVLPRTSQQHIPRSSLVDSQTPRTGFSPESSKLDSDDAASGSDNLKRKKSRLRIECEGQSADGTGKPARVKKERRLTFDVITGQIKPLTLKDPAQVESSAPTEQHRTETDKQDLTLSLPSPFQLTNWKELSGNEIIQSYLHRQSSLLSSSGIQTQSAHYYMSEYLKQEECTKRESRKTHVLVPIVLPSDLPGRTREITSSDTDRIQNQHWPGVNGCHDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 26, Cofactor required for Sp1 transcriptional activation subunit 7, CRSP complex subunit 7, Mediator complex subunit 26.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 26 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AIM36_KOMPG
Sequence: MFRQTLRLGTRMRHSPKFLGTSQMVEQFPSIAARKYSNHPSSSFNNDGGPKVRHFLFVGLVGTMLFVLVVNKINEQDPKTSLAKKKNTYSEQEWESYVAGLKRKKQRFDSSSNKEFYAVPFANKNPKQIENLKRKVSKSSSQEDVGVVDINELIAKQMNNSESAYGLLLKTTLVENDPSSQSCTYSFNWNLAKGIFSKLVCDELTRMINESPQLDRFLLLNFPNNLPEAIKFEQDVANITELIVFNEEQKEDVVVKYFDTVDKVSISK
What are the official names of this protein?
Altered inheritance of mitochondria protein 36, mitochondrial, Found in mitochondria protein 39.
What is the protein family that this protein belongs to?
Belongs to the AIM36 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: PCKG_ACIB5
Sequence: MTTVNAPEFVRHPKLIAWVEEIANLTKPAKIEWCDGSEEEYQRLIDLMIANGTMQKLNQEKHPGSYLANSDPSDVARVEDRTYICSQNKEDAGATNNWEDPAVMREKLNGLFEGSMKGRTMYVVPFSMGPLGSHIAHIGIELTDSPYVAVSMRKMARMGKAVYDVLGTDGEFVPCVHTVGAPLAEGQKDVAWPCNPEKYIVHYPETREIWSFGSGYGGNALLGKKCLALRIASVMGREQGWLAEHMLILGVTNPQGEKHYIAAAFPSACGKTNFAMLIPPAGYEGWKIETVGDDIAWIKPGEDGRLYAINPEAGFFGVAPGTNTKTNPNCMATLHKDVIYTNVAVTDDGQVWWEGLSKEVPANLTNWKGQPHVNGEKAAHPNARFTVAAGQCPSIDADWENPAGVPISAFIFGGRRADTVPLVSEAFDWVDGVYKAATMGSETTAAAVGQQGIVRRDPFAMLPFAGYNMADYFDHWLNLGAKVSEKAEASGNKLPKIFNVNWFRRDAEGNFVWPGFGQNMRVLEWIIDRCEGRANAVETPIGFVPTYEDLNWEGTEFTKEQFDLITNQDRDQWVTEIESHTELFNKLGERLPKALKERQAALLEAVKTGF
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT1B_CONCL
Sequence: RTKRDVCELPFEEGPCFAAIRVYAYNAETGDCEQLTYGGCEGNGNRFATLEDCDNTCARY
What are the official names of this protein?
Kunitz-type serine protease inhibitor conotoxin Cal9.1b, Conkunitzin-Cal9.1b.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: CANB2_MOUSE
Sequence: MGNEASYQTELCNHFDQEEIRRLGKSFRKLDLDKSGSLSIEEFMRLPELQQNPLVGRVIDIFDTDGNGEVDFHEFIVGTSQFSVKGDEEQKLRFAFRIYDMDNDGFISNGELFQVLKMMVGNNLKDWQLQQLVDKSILVLDKDGDGRISFEEFSDVVKTMEIHKKLVVFVEHGQEDLKA
What is the function of this protein?
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.  Confers calcium sensitivity.
What are the official names of this protein?
Calcineurin subunit B type 2, Protein phosphatase 2B regulatory subunit 2, Protein phosphatase 3 regulatory subunit B beta isoform.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Localizes in the mitochondria in a SPATA33-dependent manner.
Protein: RNPA_PSEMY
Sequence: MVSRGFGREKRLLTPRQFKAVFDSPSGKAPGKSVLLLARDNQLDHPRLGLVIGKKSVKLAVERNRIKRQIRESFRLNQDNLVGWDIVVVARKGLGDLENGELAQQFGKLWKRLARSRPSRDADVSPGTSDNPHA
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: Y022_RICBR
Sequence: MIRMSKRLGVILFVSCISINSFAKSMEADVNAVPEYNYDNIPYYENEGSLLVKMRLNGVFAHAKQKNLPAPTVPQPLPVGEFVKNGYGGDISTTIFFNNYFATELSLGFNVLRTKNSVLSNVSYNYGVGATPGKSKPLYMIPATITGQFHVAPFGGIRPYVGLGYHGSYMITQSSGIKIRNGNGFVGQIGLDFYAKDDTVINLDIKQYYLNPKIVYKPSLVGNQNITSRTKLNPLVVSIGIGFSF
What are the official names of this protein?
Putative outer membrane protein RBE_0022.
What is the protein family that this protein belongs to?
Belongs to the OmpW/AlkL family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: LEUC_BRUO2
Sequence: MSAPRTLYDKIWDDHVVDQQEDGTCLLYIDRHLVHEVTSPQAFEGLRMAGRPVRHPEKTLAVVDHNVPTSPDRINGIQNEESRIQVEALARNAADFGVEYYSERDKRQGIVHIVGPEQGFTLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLIQKKAKNMLVRVDGKLPAGVTAKDIVLAIIGEIGTAGGTGYVIEYAGEAIRSLSMEGRMTICNMSIEGGARAGLIAPDETTFEYIKGRPRAPQGETLEQAINYWKTLHSDEGAHFDKIVTLDAGSLPPIVSWGSSPEDVVSVTGVVPNPDDIADETKRASKWRALDYMGLKPGTKITDIAVDRVFIGSCTNGRIEDLRAAAKVVEGKKVAPTVNAMIVPGSGLVKEQAEAEGLHKIFIEAGFDWREPGCSMCLAMNDDRLKPGERCASTSNRNFEGRQGFKGRTHLVSPAMAAAAAIAGHFVDIRAWK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.