PharMolix/UniProtQA huggingface dataset:
Protein: CRYAB_SQUAC
Sequence: MDIAIQHPWLRRPLFPSSIFPSRIFDQNFGEHFDPDLFPSFSSMLSPFYWRMGAPMARMPSWAQTGLSELRLDKDKFAIHLDVKHFTPEELRVKILGDFIEVQAQHEERQDEHGYVSREFHRKYKVPAGVDPLVITCSLSADGVLTITGPRKVADVPERSVPISRDEKPAVAGPQQK
What is the function of this protein?
May contribute to the transparency and refractive index of the lens.
What are the official names of this protein?
Alpha-crystallin B chain, Alpha(B)-crystallin.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: RR7_STAER
Sequence: MSRRSTAEKETAKSDPIYRNRLVNMLVNRILRHGKKSLAYRIIYRAMKNIQQKTEKNPLSVLRQAIRGVTPNVTVKTRRVGGSTYQVPIEIRSTQAKALAIRWLLGASRKRPPGRNMAFKLSYELMDAARENGNAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CASP3_MESAU
Sequence: MENNETSVDSKSIKNFEVKTIHGSKSMDSGIYLDSSYKMDYPEMGVCIIINNKNFHKSTGMTPRSGTDVDAAKLRETFMALKYEVRNKNDLTREEIVELMKNASKEDHSKRSSFVCVILSHGDEGVIFGTDGPIDLKKLTSYFRGDYCRSLIGKPKLFIIQACRGTELDCGIETDSGTEDDMTCQKIPVEADFLYAYSTAPGYYSWRNPKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYFYH
What is the function of this protein?
Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity).  At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (By similarity).  Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (PubMed:8605870).  Cleaves and activates caspase-6, -7 and -9 (By similarity).  Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).  Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity).  Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (By similarity).  Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity).  Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity).  Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).
What are the official names of this protein?
Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_ROSCS
Sequence: MAALLNDAEIEERLGDLTGWTRQGNEIRKTFQLPSFPSAIAFVVNVAFLAEAAGHHPDIDIRWRKVTLSLSTHDAGGLTGKDFDLAAQIDEII
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: NSP1_ROTRA
Sequence: MATFKDACFHYRRVTKLNRELLRIGANSVWTPVSTNKIRGWCVECCQLTELTFCHGCSLAHVCQWCIQNKRCFLDNEPHLLKLRTFESPITKEKLQCIIDLYNLLFPINSSIVNKFKKTVKQRKCRNEFDKLWYNQLLLPITLNAAVFKFHSRKVYVFGFYEGSSPCVNLPYKLVNCIDLYDKLLLDQVNFERMSSLPSNLQSIYANKYFKLSRIPSMKLKQIYYSDFSKQNLINKYKFKSRIVLRNFTEFTWDFQLSLHYDLFNNKDKIFAALSTSSLKQFETHDLNLGRVKADVFELGRHCKPNYISSNHWQPASTISQCKWCNVKYAFRDMDWKMESMYNELLSFIQSCYKSNVSVGHCSSIERAYPLVKDVLWHSITKYIDQTIEKLFNVMNPVQVNNQKVISFHWQIDIALYTHIKMILKTERLPFTFTLDQFNSVIKGIVNQWCNVNELDNLPLCTEQTDTLVRLEEEGKLAEEYELLISDSEDDD
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7.  Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.
What are the official names of this protein?
Non-structural protein 1, NSP1, NCVP2, Non-structural RNA-binding protein 53, NS53.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP1 family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton.
Protein: IF2_KLEOX
Sequence: MTDVTIKALASEIQTSVDRLIQQFADAGIRKSADDSVTAQEKQTLLTHLNREHGSAPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEEAAKREAQLKAEREAAEQAKRELADKAKREAAEKDKVSNQQTDDMTKTAQAEKQRRENEAAELKRKSEEEARRKLEEEARRVAEEARRMAQENEKNWTEAPETPEETTDYHVTTSQHARQAEDDNDREVEGGRGRGRNAKAARPAKKGNKHAESKADREEARAAVRGGKGGKHRKGSALQQGFQKPAQAVNRDVIIGETITVGDLANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETDNGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAQVPLVVAVNKIDKPEADLDRVKNELSQYGVMPEEWGGEAQFIPVSAKAGTGIDDLLNAILLQAEVLELKAVRNGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITETDATLAAASNAILVGFNVRADASARKVIDAESLDLRYYSVIYHLIDEVKAAMSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGTIKRHNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRVGDMIEVFEIIEIQRTID
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUSP_VAR67
Sequence: MDKKSLYKYLLLRSTGDMRRAKSPTIMTRVTNNVYLGNYKNAMNAPSSEVKFKYVLNLTMDKYTLPNSNINIIHIPLVDDTTTDISKYFDDVTAFLSKCDQRNEPVLVHCVAGVNRSGAMILAYLMSKNKESSPMLYFLYVYHSMRDLRGAFVENPSFKRQIIEKYVIDKN
What is the function of this protein?
Serine/tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses.  Dephosphorylates the OPG144 protein.
What are the official names of this protein?
Dual specificity protein phosphatase OPG106, Late protein H1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Approximately 200 molecules of H1 are packaged within the virion and are essential for the viability of the virus.
Protein: TMT1A_HUMAN
Sequence: MELTIFILRLAIYILTFPLYLLNFLGLWSWICKKWFPYFLVRFTVIYNEQMASKKRELFSNLQEFAGPSGKLSLLEVGCGTGANFKFYPPGCRVTCIDPNPNFEKFLIKSIAENRHLQFERFVVAAGENMHQVADGSVDVVVCTLVLCSVKNQERILREVCRVLRPGGAFYFMEHVAAECSTWNYFWQQVLDPAWHLLFDGCNLTRESWKALERASFSKLKLQHIQAPLSWELVRPHIYGYAVK
What is the function of this protein?
(Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.
What are the official names of this protein?
N6-adenosine-methyltransferase TMT1A, Methyltransferase TMT1A, Methyltransferase-like protein 7A, Protein AAM-B, Thiol methyltransferase 1A.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: COX3_MYCPA
Sequence: MTSAVGTSGTAITSRVHSLNRPNMVSVGTIVWLSSELMFFAGLFAMYFTARAQSGGKWPPPPTELNLYQAVPVTLVLIASSFTCQMGVFAAERGDVFGLRRWYVITFLMGLFFVLGQGYEYYHLMGHGTTIPGSAYGSVFYLATGFHDLHVTGGLVAFIFLLARTAMSKFTPAQATASIVVSYYWHFVDIVWIALFTVIYFIR
What are the official names of this protein?
Probable cytochrome c oxidase subunit 3, Cytochrome aa3 subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2358_MYCBO
Sequence: MPPVFLPQIGRLTPDAVGEAIGIAADDIPMAARWIGSRPCSLIGQPNTMGDEMGYLGPGLAGQRCVDRLVMGASRSTCSRLPVIASVDERLSVLKPVRPRLHSISFIFKGRPGEVYLTVTGYNFRGVP
What are the official names of this protein?
Uncharacterized protein Mb2358.
Protein: YICR_ECO5E
Sequence: MKNNAQLLMPREKMLKFGISALTDVELLALFLRTGTRGKDVLTLAKEMLENFGSLYGLLTSEYEQFSGVHGIGVAKFAQLKGIAELARRYYNVRMREESPLLSPEMTREFLQSQLTGEEREIFMVIFLDSQHRVITHSRLFSGTLNHVEVHPREIIREAIKINASALILAHNHPSGCAEPSKADKLITERIIKSCQFMDLRVLDHIVIGRGEYVSFAERGWI
What are the official names of this protein?
UPF0758 protein YicR.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family. YicR subfamily.
Protein: B3A3_PLEMO
Sequence: MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSGRHTRRKRKKEKTSVPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGSPPKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPRTDKSPQHSGSFPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDSHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSIFGGLVRDVRRRYPYYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLEAGLEPNGSALPPTEGPRGPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
What is the function of this protein?
Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane.
What are the official names of this protein?
Anion exchange protein 3, AE 3, Anion exchanger 3, Solute carrier family 4 member 3.
What is the protein family that this protein belongs to?
Belongs to the anion exchanger (TC 2.A.31) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HBCL1_METS5
Sequence: MVTVQDFFRKFIEFQNSPNEKSLQEIVKLVGQLDLRRFNWVRDVFEDIHVKERGSKTALIWRDINTGEEAKLSYHELSLMSNRVLSTLRKHGLKKGDVVYLMTKVHPMHWAVFLAVIKGGFVMVPSATNLTVAEMKYRFSDLKPSAIISDSLRASVMEEALGSLKVEKFLIDGKRETWNSLEDESSNAEPEDTRGEDVIINYFTSGTTGMPKRVIHTAVSYPVGSITTASIVGVRESDLHLNLSATGWAKFAWSSFFSPLLVGATVVGINYEGKLDTRRYLGEVENLGVTSFCAPPTAWRQFITLDLDQFRFERLRSVVSAGEPLNPEVIKIWKDKFNLTIRDFYGQTETTAMVGNFPFLKVKPGSMGKPHPLYDIRLLDDEGKEITKPYEVGHITVKLNPRPIGLFLGYSDEKKNMESFREGYYYTGDKAYFDEEGYFYFVGRGDDVIKTSDYRVGPFEVESALLEHPAVAEAAVVGVPDTVRWQLVKAYIVLKKGYMPSKELAEEIREKMKTLLSPYKVPRIIEFVDELPKTISGKIRRVELRKREEEKRKKGEVGQNEYVF
What is the function of this protein?
Involved in the 3-hydroxypropionate/4-hydroxybutyrate cycle which incorporates carbon dioxide into cellular carbon.  Catalyzes the ligation of coenzyme A (CoA) to 4-hydroxybutyrate (4HB).  It can also use butyrate, valerate, propionate, acetate and 3-hydroxybutyrate (3HB) as substrates.
What are the official names of this protein?
4-hydroxybutyrate--CoA ligase 1, Acetate--CoA ligase, Butyrate--CoA ligase, Propionate--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ATG17_PICAN
Sequence: MAIPIAQWVADARANLAHAEQVCNDANMYLTSTSEKLRRREMKVPKLIYYLDALKQQLRLLEIIRDSLVLNLNGVMEKRAALQSQLLKDVDRLHQTIDTLKNTVVVFDGQTTLYEYISESGVEELFNGVSQNLKDIQTLIKGNRTDALLIRLTSDLDHLSNELNALDSKFRDMRLVDTQSSSIDPISKLLEINAELEHDMVAILTSFNNHYDQCEKGEAILKDPAVPQDEKDELVSVLQNDVEELPEAQRSLTSNAEIIKKNCKEVMKILDIFEDYFQRVETYVCELQEYGESKLRVQLKEFSDINTEVSRKLEIAQTHQDELVQYNSDFQQFVRSYYSLILELDRRMRVNEHISSAIDNFRSTISNIVEKDHEKRMEFLQKHGDFIPQNLVDSSVINSGTPQISINFDQEPLPAISKEVVQLAKKMQK
What is the function of this protein?
Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation.  Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles.  Plays particularly a role in pexophagy and nucleophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 17.
What is the protein family that this protein belongs to?
Belongs to the ATG17 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: FMT_ECODH
Sequence: MSESLRIIFAGTPDFAARHLDALLSSGHNVVGVFTQPDRPAGRGKKLMPSPVKVLAEEKGLPVFQPVSLRPQENQQLVAELQADVMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRGAAPIQRSLWAGDAETGVTIMQMDVGLDTGDMLYKLSCPITAEDTSGTLYDKLAELGPQGLITTLKQLADGTAKPEVQDETLVTYAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLEIEGQPVKVWKASVIDTATNAAPGTILEANKQGIQVATGDGILNLLSLQPAGKKAMSAQDLLNSRREWFVPGNRLV
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RLMC_VIBVY
Sequence: MSCPYFEQKSCTSCTHMNTPYSQQLETKDNALRTLFSDVAQSAWLAPVQSDSMHCRNKAKMVALGAAHQPTLGIESVQDGTPISLVHCPLYTQDSQALLAYLQEWIRTSGIPPYNKVKKKGELKFVLLTRSQARGEFMLRFVVRSEAALERIRHNLPRLQQAFPAVRVISANIQPIHMARLEGEQEIFLTDAHYLLEEFNGVPMVVRPKSFFQTNPHVAAQLYATARDWVAELKPRQMWDLFCGVGGFALHCAPHAEQVIGIEIEEEAINSAKLSAQQLGIGNLRFSALDSAAYSQAQTQAADLILVNPPRRGLGQALSEQLEQLAPQYLIYSSCNPVTMQQDLAHLPSYQVERAQWFDMFPHTDHAEVMMLLVRQ
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: PEX34_YEAST
Sequence: MVSKKNTAEISAKDIWENIWSGVSSLLDFFAVLENLGVVNDKLYVSGLLRKVWLCYSCISVIKCVWKLIKLCKVKFKIDQRLDGEGNGLVKDKLINFKKKYNEHIRHITAALLQDLSYLMVLIYPGTRLFKRLSNIITLCRIIV
What is the function of this protein?
In concert with the three peroxisome divisional factors, PEX11, PEX25 and PEX27, controls peroxisome morphology and abundance under conditions of peroxisome proliferation.  Maintains mature peroxisomes in actively dividing cells.
What are the official names of this protein?
Peroxisomal membrane protein PEX34, Peroxin-34.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: RS18_LEPBL
Sequence: MEGKPQRKQNKYKKKVCRFTADPELAKQINYKNIELLERFITNRGKIIPRRITGTSARYQRVLAREIRKARSIGLLPYKVN
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: DAPF_SALTI
Sequence: MQFSKMHGLGNDFMVVDAVTQNVFFSPELIRRLSDRHLGVGFDQLLVVEPPYDPELDFHYRIFNADGSEVSQCGNGARCFARFVRLKGLTNKRDIRVSTANGRMVLSVTEDELVRVNMGEPNFEPAQVPFRANKAEKTYIMRAAEQTILCGVVSMGNPHCVIQVDNVDTAAVETLGPVLESHERFPERANIGFMQVVRREHIRLRVYERGAGETRACGSGACAAVAVGIQQGLLAEEVRVELPGGRLDIAWKGPGHPLYMTGPAAHIYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCB_BURVG
Sequence: MVSLKDSHFDLFHLPAQFALDDAALDDAYRTVQTQVHPDRFAAAGDAQKRIAMQWATRANEAYRTLRDPLQRASYLLSLRGVDIGAENNTAMEPAFLMQQMEWREGIEDAAAARNVDALDALLAELRDEKRVRIERLGTLLDSGADQAAAEAVRQLMFIERVASEVGAQIERLET
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: MDTB_SALPK
Sequence: MQVLPPGSTGGPSRLFILRPVATTLLMAAILLAGIIGYRFLPVAALPEVDYPTIQVVTLYPGASPDVMTSSVTAPLERQFGQMSGLKQMSSQSSGGASVVTLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPIYSKVNPADPPIMTLAVTSNAMPMTQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAIRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPERAVTLSANDQMQSADEYRKLIIAYQNGAPVRLGDVATVEQGAENSWLGAWANQAPAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVRDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCACMLSQQSLRKQNRFSRACERMFDRVIASYGRGLAKVLNHPWLTLSVAFATLLLSVMLWIVIPKGFFPVQDNGIIQGTLQAPQSSSYASMAQRQRQVAERILQDPAVQSLTTFVGVDGANPTLNSARLQINLKPLDARDDRVQQVISRLQTAVATIPVVALYLQPTQDLTIDTQVSRTQYQFTLQATTLDALSHWVPKLQNALQSLPQLSEVSSDWQDRGLAAWVNVDRDSASRLGISIADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTASTPGLAALETIRLTSRDGGTVSLSAIARIEQRFAPLSINHLDQFPVTTFSFNVPEGYSLGDAVQAILDTEKTLALPADITTQFQGSTLAFQAALGSTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALIIAGSELDIIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIAMVGGLLVSQVLTLFTTPVIYLLFDRLSLYVKSRFPRHKEEA
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HASP_STRCO
Sequence: MKTESDVQTGAPTAADGALIALAREVCPGFAPGEVVYRSRTSLVVGGELDGVEALAKVRTPDWRRQCLREIDTYDLFDAVPPPVPVPRRFASDRERAVLVMERLTGEVLAPDRFPVTPVSREDLAGVLEAVERLRHWRPAAAGAWAVDYRGMLEGVHAQGVFDDGHWADLLRLLELSGAPREFGHGDLVLANVVRSRGRQVLIDWASSALYLPGLDLAQLWMLLGDVPGARARIEVEVADRADDRDGMMPFLVNLTLLLYRERRAHRRFTDDASRARAVGLDAAWELTRHRVRQCLATAG
What is the function of this protein?
Phosphotransferase that is responsible for the production of the 3-phosphohydroxyasparaginyl residues found at position 9 in the non-ribosomally synthesized calcium-dependent antibiotic (CDA) derivatives CDA1b and CDA2a/b.  It is not known whether the phosphorylation reaction takes place before, during or after peptide assembly.
What are the official names of this protein?
3-hydroxyasparagine phosphotransferase, CDA 3-hydroxyasparaginyl phosphotransferase.
Protein: RBL_DARCA
Sequence: VGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLSHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDYIEKDRARGIYFSQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREARKW
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HH_DROWI
Sequence: MDSQSNQTPWASASVTCLSLDAKRHSQCLDDAIKSGHQVNYSPARSLRYIAYTQRCGIRLTMLMLIMCLTFMPAHSCGPGRGLGRRRVQNLYPLVLKQTVPNLSEHQLGASGPLEGEIPRDSPKFKDLVPNYNRDIVFKDEEGTGADRLMTKRCREKLNALAYSVMNEWPGVRLLVIESWDEDHDHGQESLHYEGRAVTIGTNDRDLSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSTISHVHGCFTPESTAQMENGEKKPLSQLSIGDRVLSMGSNGQPVYSEVILFMDRNLEQLENFVQLHTDGGAVLTVTPAHLISVWQPDSQQLNYVFADRVEEMNYVLVNDVVTGELLPQRVIKVTSVHSKGVVAPLTREGTIVVNSVVASCYAVINSQSLAHWGLAPMRLLSSLQSLMPAKGQLRTTSSATQPTKEVSRAEQQNGIHWYANALYKVKDYVLPKSWRHE
What is the function of this protein?
The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.  Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks.  Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc.  In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu).  Essential component of a signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection.  During photoreceptor differentiation, it up-regulates transcription of Ubr3, which in turn promotes the hh-signaling pathway by mediating the ubiquitination and degradation of cos.
What are the official names of this protein?
Protein hedgehog.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. SUBCELLULAR LOCATION: [Protein hedgehog N-product]: Cell membrane; Lipid-anchor. Note=The N-terminal peptide remains associated with the cell surface. Heparan sulfate proteoglycans of the extracellular matrix play an essential role in diffusion. Lipophorin is required for diffusion, probably by acting as vehicle for its movement, explaining how it can spread over long distances despite its lipidation.
Protein: HSP1_MURLO
Sequence: MARYRRHSRSRSRSRYRRRRRRRSRHHNRRRTYRRSRRHSRRRRGRRRGYSRRRYSRRGRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.