PharMolix/UniProtQA huggingface dataset:
Protein: SYDP_PSEA6
Sequence: MTSTVNQSLDDFMGRFAAFVKEHAEAGAIEYDEDWPSPCYATDVTPESGTSIPWKPVLREQTSEFKDLSEALELTLHPDVAQFYSRYWSDNIVAQHPSGKLQILQAWNEEDFERLQQNIVGHILMKRRLRQPETIFIALTDEDDFVLSVDNQTGAVMLEQVGLQPKEQISPDLATFLDEIEPTTTD
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: ANKR6_MOUSE
Sequence: MSQQDAVAALSERLLIAAYKGQTENVVQLINKGAKVAVTKHGRTPLHLAANKGHLSVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEILTALIREGCALDRQDKDGNTALHEAAWHGFSQSAKLLVKAGANVLARNKAGNTALHLACQNSHSQSTRILLLGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLNAFCSVHEKNQAGDTALHVAAALNHKKVVKVLLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQILRFSRGRSLRKRRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVPQKEEARRDCPPASQEPRKDERRRKSRPEVSALSDPTPAADQQPGHQKNLHSHHHPKKKSRHRCWSPPPPHGFRAYQLYTLYRGEDGKVMQAPIKGCRCEPLINKLENQLEATVEEIRAELGSVQDKVNAKLGQMESKTQHQMCVLDKLMVERLSAERTECMNRLQQHAAAEKQEGEKRQMSLVDELKAWCMLKIQSLELRLSGESRTFRAKSTPPPSDSTPAVDQPVVAAGPGAASDSSSQVVRPKDKALNASAAHSHQQELPPSDCTGSGLRKIKAPGASRCDQQTGSCVNRGTQTKKSGRSGQTKHRGQQPTASSPSGQQPSAASSDVRDASQALELTQYFFEAVSAQMEKWYERKIEEARSQASQKAQQDEATLKEHIRSLEEELARLRTKVQK
What is the function of this protein?
Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.
What are the official names of this protein?
Ankyrin repeat domain-containing protein 6, Diversin.
Protein: CSPL5_VITVI
Sequence: MEVESKTSFGGMESKSKEVKVVTGGKLRPFDLVLRVVALALTLVAAVLLGVDKQTKVVSLQLLPTLPPMDVPVTAKWRYLSAFVYFVVSNAIACSYAALSLLLSVGNSKGNKGLGLAITVMDLVMVALLFSSNGAAGAIGLMGYEGNSRVRWGKVCNVFGKFCNQVAVALGLSFFGGLAFFLLVVMAAFALNKRH
What are the official names of this protein?
CASP-like protein 1E2, VvCASPL1E2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECO_BREBN
Sequence: MLVKWEGIVIRSVDYGESSKVVTMFTRENGKLGVMARGAKKTKSRLAAVSQLFSHSYYLCKAGPGTGMPDLSQGDMLDSFRDMRQSLTATAYAAYIAELLDRLTQEREPNPYLFQLLLHTFRHLDEGRDAEILCRIFETKMLIVAGISPQLTACANCGEQREPYAISVGQGGLLCPVCLPSDPYAMAVTPSTWKLLRLFQVFDLERLGDIEVKPATRNQLKHVLRSFMDEYLDLRLKSRSFLEQLERMERMTQSDQD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: MBB1_YEAST
Sequence: MYKVSACGVRIMSGISEIWIGELRDYKYALRLDREEYPAVLVYEYDSSSTRNYLFTIKYSDQRPNWQLITRDAALTAYDLLNRGGEFTTLSFPGATIHRSVSELSRLH
What is the function of this protein?
May be involved in metabolic processes.
What are the official names of this protein?
Uncharacterized protein MBB1.
Protein: MSHB_NOCDD
Sequence: MMVHAHPDDESIVTGATLAKYAAEGAGVTLVTCTLGEEGEVIPDDLAHLTSDREGTLGEHRIGELDKACLALGVRDHRFLGGPGRYRDSGMMGAPTNEHPRAFWGADVEEAATLLAQVIREVRPHVLVSYDEHGGYGHPDHIQAHRVARRAFLRAGERAMPGTPWQVRKLYAIAQPVSRIEESIARLREESGSFTPPARVSDIARGTPETAVTTRVDATDHWAAKALAMRAHATQITVEGERFALSNDIAQEIDAVEYFTLLVGPTPRIQHGEYETDLFAGL
What is the function of this protein?
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
What are the official names of this protein?
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, GlcNAc-Ins deacetylase, N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family.
Protein: HSAA_MYCTO
Sequence: MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNWHLALFDQRAQEEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKDGRPVDFGSFLIPRSEYEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFGLPPGDTMV
What is the function of this protein?
Catalyzes the o-hydroxylation of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol.
What are the official names of this protein?
Flavin-dependent monooxygenase, oxygenase subunit HsaA, 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, oxygenase subunit, 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the HpaH/HsaA monooxygenase family.
Protein: C2C4B_HUMAN
Sequence: MRLLEKLCSSAAGSSAPKPAFAKVLTPNRIPEFCIPPRLPAPCTLESPIRAAAVPRRCAAESDLWPRAADEDAGRTDWDPRSQAALSLPHLPRVRTTYGFCALLESPHTRRKESLLLGGPPAPRPRAHSCGGGGGPDAPLGTLCGPRGPGPATPAAPGGPRLPQDALAAGPRRCRLLRVPDGLLSRALRAGRSRRLARVRSVSSGNEDEERRAGSESPARAPSSSPLSSRAPLPERLEAKGTVALGRAGDALRLAAEYCPGTRRLRLRLLRAESLFGGAPGPRAVRCRLSLVLRPPGTARWQCSAVVGRSRKASFDQDFCFDGLSEDEVRRLAVRVKARDEGRGRDRGRLLGQGELSLGALLLL
What is the function of this protein?
May be involved in inflammatory process.  May regulate cell architecture and adhesion.
What are the official names of this protein?
C2 calcium-dependent domain-containing protein 4B, Nuclear-localized factor 2, Protein FAM148B.
What is the protein family that this protein belongs to?
Belongs to the C2CD4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CNSP_PENEN
Sequence: MSTTTVITPGTITREKNENGAPLYPDYMPFYDPLEKVEDIGAFEHFDPGHRADPKLPNLLKNATKVWELSPHVGTEIHGVQLSQLDSAGLDELALLAAQRGALVFRDQDFVNIGFDAQKKLVSHFGPLHIHGWAPHPAAGSEEHMIIYDHKDDLRVRQSWAGRSPVQWHTDQSPEQQPPGTTFIAMLESPTTAGGDTLVSSSVRAYSSLSPRFRKRLEGLTAIHTNNDGVSQELKHGQQAVMRRGVLQAEHPVVLVHPVTKQKALYVNPVYTKKIVGFDQEESDCILKFLFDHIAKRQDFSCRIRYEAGTVLVWDQRVTNHSQTLDYPIGDRRHGFRLTPLANKPIPAKIEEDDEEFSTDDARHLVGNAS
What is the function of this protein?
Alpha-ketoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals (PubMed:25571861).  Communesins are biosynthesized by the coupling of tryptamine and aurantioclavine, two building blocks derived from L-tryptophan (PubMed:25571861).  The L-tryptophan decarboxylase cnsB converts L-tryptophan to tryptamine, whereas the tryptophan dimethylallyltransferase cnsF converts L-tryptophan to 4-dimethylallyl tryptophan which is further transformed to aurantioclavine by the aurantioclavine synthase cnsA, probably aided by the catalase cnsD (PubMed:25571861).  The cytochrome P450 monooxygenase cnsC catalyzes the heterodimeric coupling between the two different indole moieties, tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacyclic communesin scaffold (PubMed:26963294).  The O-methyltransferase cnsE then methylates the communesin scaffold to produce communesin K, the simplest characterized communesin that contains the heptacyclic core (PubMed:25571861).  The dioxygenase cnsJ converts communesin K into communesin I (PubMed:25571861).  Acylation to introduce the hexadienyl group at position N16 of communesin I by the acyltransferase cnsK leads to the production of communesin B.  The hexadienyl group is produced by the highly reducing polyketide synthase cnsI, before being hydrolytically removed from cnsI by the serine hydrolase cnsH, converted into hexadienyl-CoA by the CoA ligase cnsG, and then transferred to communesin I by cnsK (PubMed:25571861).  Surprisingly, cnsK may also be a promiscuous acyltransferase that can tolerate a range of acyl groups, including acetyl-, propionyl-, and butyryl-CoA, which lead to communesins A, G and H respectively (PubMed:25571861).  The roles of the alpha-ketoglutarate-dependent dioxygenases cnsM and cnsP have still to be determined (PubMed:25571861).
What are the official names of this protein?
Alpha-ketoglutarate-dependent dioxygenase cnsP, Communesin biosynthesis cluster protein P.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
Protein: CR7AB_BACUA
Sequence: MNLNNLGGYEDSNRTLNNSLNYPTQKALSPSLKNMNYQDFLSITEREQPEALASGNTAINTVVSVTGATLSALGVPGASFITNFYLKITGLLWPHNKNIWDEFMTEVETLIEQKIEQYARNKALAELEGLGNNLTIYQQALEDWLNNPDDPATITRVIDRFRILDALFESYMPSFRVAGYEIPLLTVYAQAANLHLALLRDSTLYGDKWGFTQNNIEENYNRQKKHISEYSNHCVKWYNSGLSRLNGSTYEQWINYNRFRREMILMVLDIAAVFPIYDPRMYSMETSTQLTREVYTDPISLSISNPDIGPSFSQMENTAFRTPHLVDYLDELYIYTSKYKAFSHEIQPDLFYWCVHKVSFKKSEQSNLYTTGIYGKTSGYISSGAYSFRGNDIYRTLAAPSVVVYPYTQNYGVEQVEFYGVKGHVHYRGDNKYDLTYDSIDQLPPDGEPIHEKYTHRLCHATAISKSTPDYDNATIPIFSWTHRSAEYYNRIYPNKIKKIPAVKMYKLDDLSTVVKGPGFTGGDLVKRGSNGYIGDIKATVNSPLSQKYRVRVRYATSVSGLFNVFINDEIALQKNFQSTVETIGEGKDLTYGSFGYIEYSTTIQFPNEHPKITLHLNHLSNNSPFYVDSIEFIPVDVNYDEKEKLEKAQKAVNTLFTEGRNALQKYVTDYKVDQVSILVDCISGDLYPNEKRELQNLVKYAKRLSYSRNLLLDPTFDSINSSEENGWYGSNGIVIGNGDFVFKGNYLIFSGTNDTQYPTYLYQKIDESKLKEYSRYKLKGFIESSQDLEAYVIRYDAKHRTLDVSDNLLPDILPENTCGEPNRCAAQQYLDENPSSECSSMQDGILSDSHSFSLNIDTGSINHNENLGIWVLFKISTLEGYAKFGNLEVIEDGPVIGEALARVKRQETKWRNKLAQMTTETQAIYTRAKQALDNLFANAQDSHLKIDVTFAEIAAARKIVQSIREVYMSWLSVVPGVNHPIFTELSGRVQRAFQLYDVRNVVRNGRFLNGLSDWIVTSDVNVQEENGNNVLVLNNWDAQVLRNVKLYQDRGYVLRVTARKIGIGEGYITITDEEGHTDQLRFTACEEIDASNAFISGYITKELEFFPDTEKVHIEIGETEGIFLVESIELFLMEELC
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of Coleoptera.
What are the official names of this protein?
Pesticidal crystal protein Cry7Ab, 130 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryVIIA(b).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: REL2_HUMAN
Sequence: MPRLFFFHLLGVCLLLNQFSRAVADSWMEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETINMMSEFVANLPQELKLTLSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC
What is the function of this protein?
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.  May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
What are the official names of this protein?
Prorelaxin H2.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: THI4_HALWD
Sequence: MSFDEFADVSEAQVTRAIAKDWGNEFIDRVDTEVIIVGGGPSGLVTAKELAERGVDVTIVEKNNYLGGGFWLGGFLMNKVTVRDPAQSVLDELDVPYEESDEASGLYVADGPHAVSSLIKSACDAGAEVQNMTEFTDVVTRENHRVGGIVLNWTPVHALPRELTCVDPVAVESDLVVDSTGHDAVVISKLSERGVLNAPGIEHANEHNTGMDNTADDEYGAPGHDSPGHDSMWVSRSEDQVVEHTGVVHPGVVATGMAVATVEGLPRMGPTFGAMLLSGKRGAQACLNELGREATPIDFTPAAPADD
What is the function of this protein?
Involved in biosynthesis of the thiamine precursor thiazole.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate.  The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
What are the official names of this protein?
Thiamine thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
Protein: YBIX_ECO7I
Sequence: MMYHIPGVLSPQDVARFREQLEQAEWVDGRVTTGAQGAQVKNNQQVDTRSTLYAALQNEVLNAVNQHALFFAAALPRTLSTPLFNRYQNNETYGFHVDGAVRSHPQNGWMRTDLSATLFLSDPQSYDGGELVVNDTFGQHRVKLPAGDLVLYPSSSLHCVTPVTRGVRVASFMWIQSMIRDDKKRAMLFELDTNIQSLKSRHGESEEILSLLNLYHNLLREWSEI
What are the official names of this protein?
PKHD-type hydroxylase YbiX.
Protein: CYC2_CERS4
Sequence: MKFQVKALAAIAAFAALPALAQEGDPEAGAKAFNQCQTCHVIVDDSGTTIAGRNAKTGPNLYGVVGRTAGTQADFKGYGEGMKEAGAKGLAWDEEHFVQYVQDPTKFLKEYTGDAKAKGKMTFKLKKEADAHNIWAYLQQVAVRP
What is the function of this protein?
Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway.  However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.
What are the official names of this protein?
Cytochrome c2, Cyt c2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DXR_PLAFX
Sequence: MKKYIYIYFFFITITINDLVINNTSKCVSIERRKNNAYINYGIGYNGPDNKITKSRRCKRIKLCKKDLIDIGAIKKPINVAIFGSTGSIGTNALNIIRECNKIENVFNVKALYVNKSVNELYEQAREFLPEYLCIHDKSVYEELKELVKNIKDYKPIILCGDEGMKEICSSNSIDKIVIGIDSFQGLYSTMYAIMNNKIVALANKESIVSAGFFLKKLLNIHKNAKIIPVDSEHSAIFQCLDNNKVLKTKCLQDNFSKINNINKIFLCSSGGPFQNLTMDELKNVTSENALKHPKWKMGKKITIDSATMMNKGLEVIETHFLFDVDYNDIEVIVHKECIIHSCVEFIDKSVISQMYYPDMQIPILYSLTWPDRIKTNLKPLDLAQVSTLTFHKPSLEHFPCIKLAYQAGIKGNFYPTVLNASNEIANNLFLNNKIKYFDISSIISQVLESFNSQKVSENSEDLMKQILQIHSWAKDKATDIYNKHNSS
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, 1-deoxyxylulose-5-phosphate reductoisomerase, DOXP reductoisomerase, DXP reductoisomerase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: VTM2L_MOUSE
Sequence: MGAPLAAALGALHYLALFLQLGGATRPAGHAPWDNHVSGHALFTETPHDMTARTGEDVEMACSFRGSGSPSYSLEIQWWYLRSHRDWTDKQTWASNQLKASQQEDSGKDATKISVVKVVGSNISHKLRLSRVKPTDEGTYECRVIDFSDGGRGVPRVLCLLIPLPAPPRAPRPRGQPPGEEPGRGPTLLFLIILPGTGSGTPREAEPHQPHAGGCPARQS
What are the official names of this protein?
V-set and transmembrane domain-containing protein 2-like protein.
Protein: METK_LACP3
Sequence: MQERHLFTSESVSEGHPDKIADQISDAILDAMLEQDPDSRVACETTVTTGLVLVVGEISTKAYVDIQSVVRGTIKKIGYTKESGFDPDSVGVLVALDEQSPDIAQGVDESLEARESDTDPLDKIGAGDQGMMFGFAIDETENYMPLPISLAHALMRKTDSLRHKGEISYLRPDAKAQVTVEYDDDDNPIRVDSVVVSVQHDPDVTLEEIRRDVEAKIIRTVIPEALMDDDTKIYVNPTGRFVLGGPQADSGLTGRKIIVDTYGGFARHGGGAFSGKDATKVDRSASYAARYIAKNVVAAGLAKRVEVQLAYAIGVAKPVSVSVNTFGTSAVSEDVIEQAIRENFDLRPAGIIKMLDLKRPIYEQTAAYGHFGRTDVDLPWEHLDKVQALLKYRD
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_SYNY3
Sequence: MGRSLKKGPFVAASLLRKIDKLNDKGDKQVVKTWSRASTILPQMVGHTIAVHNGRQHVPVFVSEQMVGHKLGEFAPTRTFRSHSKSDKKARK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: YIHI_YERPE
Sequence: MKQPNKAPRANIAAPKGTATPKRRRKTRDELDAEARDRKRQKKHSGNRSGARTNVEGSNKKGHSQTQEKDPRVGSKVPVPLVIESQVKAKSMPKPVEKNVVKPRLTPEEELAKLENDERLDALLDRLDNDEVLNKEDQAYVDLTLDRIDALMEQLGIELGDDEDDVEREEKQEDILQLLKRGNPKDTF
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: MURC_ALKOO
Sequence: MTTIDMNQDLGKHIHLIGIGGISMSAIAEILLNQGYRVSGSDMNDSNIINKLRAHGAEIFIGHNEDNVKDPDLVVYTAAIKEHNPERMAAKERNIPQIDRAEMLGIIMKNYKKAIAVSGSHGKTTTTSLISLIMEYSNLDPTIMVGGELDEIGGNIKIGNSEHFITEACEYVESFLKFYPFIGIILNIDEDHLDYFKDLNHIKEAFRKFINLIPQEGFLIANGDDANVQEILHSIECNLITYGLDSSNTFVARNISFTNDGYPIFTVDFKGESMGTFELNIPGKHNIYNALASIATAYLLGVEPSEIQNHIKKFRGIHRRFDILGEVKGCKIVDDYAHHPVEISATLEAAKNYPHNKIWCVFQPHTFSRTKALLEDFSRSFTNADHIIITDIYAAREQDTGEVHSEILANMIQKNNMHSQVRYMKDFEDIAAYIYDHMEPGDLVLTMGAGNVYQIGQKILQRHNE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y833_FRATN
Sequence: MILTTADTLGKREIIEYKGLVTGIIVRTPTITQGILGGLKNIIGGKNTSYTNVCKEARLHAEQEMINQAKELGANAIVAIRYDSSSLGGNTSGTEVFCYGTAVVVR
What are the official names of this protein?
UPF0145 protein FTN_0833.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: SYT_STRAW
Sequence: MSDVRVIIQRDSEREERVVTTGTTAADLFPGERTVVAARVGGELKDLAYEVKDGEEVEPVQISSEDGLNILRHSTAHVMAQAVQELFPEAKLGIGPPVKDGFYYDFDVAKPFTPEDLKAIEKKMQEIQKRGQRFSRRVVTDEAAREELADEPYKLELIGIKGSASNDDGANVEVGSGELTIYDNLDAKTGDLCWKDLCRGPHLPTTRNIPAFKLMRNAAAYWRGSEKNPMLQRIYGTAWPSKDELKAHLDFLAEAEKRDHRKLGNELDLFSIPDQIGSGLAVFHPKGGIVRRVMEDYSRRRHEEEGYEFVYTPHATKGKLFETSGHLDWYADGMYPPMQLDEGVDYYLKPMNCPMHNLIFDARGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRARGFTQDDAHIYCTREKMADELDKTLTFVLNLLRDYGLTDFYLELSTKDPEKFVGSDEVWEEATETLRQVAEKQGLPLVPDPGGAAFYGPKISVQAKDAIGRTWQMSTVQLDFNLPERFDLEYTGPDGSKQRPVMIHRALFGSIERFFAVLLEHYAGAFPAWLAPVQAVGIPIGDAHVEYLQKFAAEAKKKGLRVEVDSSSDRMQKKIRNAQKQKVPFMVIAGDEDMTAGAVSFRYRDGSQENGIPLDEAIAKIAKVVEERTQV
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_HAEDU
Sequence: MNILLSNDDGYHAEGIQTLATRLREAGHCVTVIAPDRNRSAASSCLTLMEPIRVHQLGTFDYSVIAGTPADCVHLALNGLFETSFDLVVSGINHGANLGDDVVYSGTVAAALEGRHLRLPSLAVSLVGKQSEGHLFGNNHFETAAQVVLDVLPKLVDMALPRQILNINVPDLPYSAIKGMLVTRLGQRSPSAEILKSQDPRGSTIYWLGENGSAIDNGEGTDFYALAHDYVSITPIHADMTAHHAIKVLSEML
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBC12_CAEEL
Sequence: MFNLQKRINGNNEDGRYLETRIAVRDKLLAQELQQLETALRDQKQKLWHLEVPSTSCLHELELTVTPQEGIYRGGKFRFKITVPPEYNNVPPVVKCLTKVWHPNINEDGSICLSILRQNSLDQYGWRPTRNLTDVVHGLVSLFNDLMDFNDALNIQAAQMWSQNRESFNHRVREYISRYC
What is the function of this protein?
Accepts the ubiquitin-like protein NEDD8 from the uba-3-ula-1 E1 complex and catalyzes its covalent attachment to other proteins (PubMed:10993680).  Plays a role in male tail tip morphogenesis (PubMed:21408209).
What are the official names of this protein?
NEDD8-conjugating enzyme ubc-12, NEDD8 carrier protein, Ubiquitin-conjugating enzyme E2 12.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI11_HUMAN
Sequence: MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCRENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
What is the function of this protein?
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (By similarity).  Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (By similarity).  May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (By similarity).  May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity).  Mediates MED15 ubiquitination leading to proteasomal degradation (PubMed:16904669).  May contribute to the innate restriction of retroviruses (PubMed:18248090).  Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression (PubMed:18248090).  Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain (PubMed:18248090).  May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle (PubMed:18248090).  Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 (PubMed:27498865).  Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (PubMed:27498865).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM11, Protein BIA1, RING finger protein 92, Tripartite motif-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MEND_MYCTF
Sequence: MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: RS17_YERPN
Sequence: MTDQIRTLQGRVVSDKMEKSMVVAIERVVKHPIYGKFIRRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAIL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.