PharMolix/UniProtQA huggingface dataset:
Protein: SYT_LACCB
Sequence: MALDITFPDGNVKQFPDGTTVKAITEGISNSLAKKAVAGKLDGDLIAYDEPIAHSGQLQIMTKDDAEGLTVLRQTAAFVLAAALKDLYPDIHFGQGQATEDGFYYDTDRADGQVSVDDLPTVQKKMEAIIKENAALEPVVLSRAEAFQAFKNDPFKKQLVEAAGDPIKGYKLGDFVDFEEKVLLPSLKDLKHLKLLSVAGAYWQGKSSNPMLQRIYGTAYWSEKGLEDDAKRRQEAAEHDHRVIGRDLDLFFVDPKVGAGLPYWMPNGATIRRVIERYIIDKEIADGYEHVYTPVLANLDLYKTSGHWDHYREDMFPPMDMGDGEMLELRPMNCPSHIQIYNHHIRSYRELPLRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVALDQVQEEFKKILRLIMDVYEDFNITDYSFRLSYRDPKNTEKYFDDDEMWTRSQSMLKGAMDDLKLDYYEAEGEAAFYGPKLDIQTKTALGNDETMSTIQLDFMLPERFNLTYVGKDGEEHRPVMIHRGIVGTMERFIAYLTEIYKGAFPTWLAPTQAVLIPVNNDLHLDYVNRIKKQMLAAGLRVKVDDRNEKMGYKIREAQTKKIPYTVVVGDKELNDAAVSVRRYGDEHTEEEAGNMFIDALVAEVKNYSRDGKTKPGEATKVLGD
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_LACDB
Sequence: MRLLGLDVGSKTIGVAVSDPLGITAQAVMTIPIDEDRHNFGMRSLKKLVREYEANGFVLGLPKNMDGTAGRSVSRSKAMGERLEQKFGLPVYYDDERLTTVASERILVEEAGMHDRRQRKEVVDQMAAVLILQNYLDLQRKE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPM2_CHICK
Sequence: MEAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQGLQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEEADRKYEEVARKLVVLEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLGEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
What is the function of this protein?
Binds to actin filaments in muscle and non-muscle cells.  Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.  Smooth muscle contraction is regulated by interaction with caldesmon.  In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
What are the official names of this protein?
Tropomyosin beta chain, Beta-tropomyosin, Tropomyosin-2.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Associates with F-actin stress fibers.
Protein: GRB10_PIG
Sequence: MALAGGPDSFLHHPYYQDQVEQTSPHHPRDLAGPGFPAQPDRLAPHQEDDVDLEALVNDMDASLESLCSASETAPLLHNGQHARGPPPPGARPLRPQASPRHRVPRSQPLHILAARRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLSPGSLPPGQAAAKQDVKVFSEDGTCKVVEILADMTARDLCQLLVYRSHCVDDNSWTLVEHHPHLGLERGLEDHERVTQVQHTLASESKFLFRKNYAKYEFFKNPTNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGRKSWKKLYVCLRRSGLYCSTKGASKEPRHLQLLADLEDSSIFSLIAGRKQYGAPTDYGFCIKPNRVRTEAKELRLLCAEDEQSRTCWMTAFRLLKYGMLLYQNYRVPQQRKAVLSPFSAPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
What is the function of this protein?
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways.  Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors.  The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation.  Delays and reduces AKT1 phosphorylation in response to insulin stimulation.  Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation.  Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways.  A similar role in the mediation of ubiquitination has also been suggested with INSR.  Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6.  Positive regulator of the KDR/VEGFR-2 signaling pathway.  May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 (By similarity).
What are the official names of this protein?
Growth factor receptor-bound protein 10, GRB10 adapter protein.
What is the protein family that this protein belongs to?
Belongs to the GRB7/10/14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBID_CROS8
Sequence: MKYHDLRDFLALLEQQGELKRITLPVDPYLEMTEIADRTLRAGGPALLFENPKGHTMPVLCNLFGTPKRVAMGMGQEDISALREVGKLLAFLKEPEPPRGFRDLFDKLPQFKQVLNMPTKRLRNAPCQEKVWQGDEVDLNRIPIMQCWPDDAAPLITWGLTVTRGPHKERQNLGIYRQQLIGKNKLIMRWLSHRGGALDFQEWCQAHPGERFPVAVALGADPATILGAVTPVPDTLSEYAFAGLLRGTKTEVVKCLSNDLEIPASAEIVLEGYIEPGEMAPEGPYGDHTGYYNEIDNFPVFTVTHVTQRENAIYHSTYTGRPPDEPAVLGVALNEVLVPILQKQFPEIVDFYLPPEGCSYRLAVVTMRKQYAGHAKRVMMGVWSFLRQFMYTKFVIVCDDDINARDWNDVIWAITTRMDPARDTVMVENTPIDYLDFASPVSGLGSKMGLDATNKWPGETQREWGTPIKKDPNVTARIDAIWDELAIFHDGKGA
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NNJA4_MAIZE
Sequence: MWSPIPGTLMRTSSLPAVIEASGNDDWKKRKEAQSLKRLEVKKKRIERRNSLACNTSKEAAGQSPKEMNANTDKLVSSDETIVSANESHSSGKHLVKGLPPKYQATITSEDSSSAMRKKPNSAFKAITEEQNSSSSVPSSGEAISSVTAPSLPLLSLVPITATLGSREDQSILGRAGARANGMGDVERRMMQEMPGVFTKGLSNGSRVEGFLYKYSKGEVRIVCICHGSFLTPSEFVEHAGAGKVDNPLRHIVVSATPNL
What are the official names of this protein?
Ninja-family protein 4.
What is the protein family that this protein belongs to?
Belongs to the Ninja family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YUKB_BACSU
Sequence: MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFNSGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFTGNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKINANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRTPRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVSLAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFHFPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDDLMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDLRFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLEDDKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTLVRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVSFLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAGTTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGSKNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAELKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATDSKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDTGLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLFPSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADVYTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFREKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFMLTATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFAQMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLERKPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGLFDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRFSQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTEMKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESAR
What is the function of this protein?
Required for YukE secretion.  Probable component or regulator of the ESX/ESAT-6-like secretion system (BsEss).
What are the official names of this protein?
ESX secretion system protein YukB.
What is the protein family that this protein belongs to?
Belongs to the EssC family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPD_STRPF
Sequence: MTKKEQALIEQYAKSLVEVASEHHSLDTLQADVLAILETFETTNLDQSLSSLAVPHAEKIKLLTLLERNNSVYMNNFLNLILQNEREAYLYQMLQAVLNEIAIVSNQYNVTVTSSLPLTEEQKSRVRAVVAKKFAVTAGRLIEKVDPSLIGGFIISVNNKVIDTSIRRQLQAFKMNLK
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL35_EDWI9
Sequence: MPKIKTVRGAAKRFKKTAGGGFKRKHANLRHILTKKSTKRKRHLRPKSQVSKGDLGLVVACLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: APT_SALPC
Sequence: MTATAQQLEFLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIELLVERYKNAGITKVVGTEARGFLFGAPVALGLGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDNVLVVDDLLATGGTIEATVKLIRRLGGKVTDAAFIINLFDLGGEQRLEKQGITCYSLVPFPGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPD13_HUMAN
Sequence: MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVLGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS
What are the official names of this protein?
Putative speedy protein E13.
What is the protein family that this protein belongs to?
Belongs to the Speedy/Ringo family.
Protein: BRXL3_ORYSJ
Sequence: MLACIACSSKEGGEDGSRGAATPHGRDAVKSLTSQLKDMVLKFSGSNKHQHYKAATAGSPSFRSRSYRRPYPGFIDDSAFMTTTRPGGEAYMYTRAAPPPPVRAASTSMATWDMTRSKSNRGWQQDAGRSPGGTTWIQSIEEEAGADDVTVVEDAVPREWTAQVEPGVQITFVTLPGGGNDLKRIRFSRERFGEDRAKVWWEHNRDRIQAQYL
What are the official names of this protein?
Putative protein Brevis radix-like 3, OsBRXL3.
What is the protein family that this protein belongs to?
Belongs to the BRX family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRF_PYRAB
Sequence: MIVLALDVYDEDRALKIAEETKDYVAMIKVNWPLIIGSGLDIIRKLKDRTGLKIIADLKLADIPNTNKLIARKVYEAGADYIIVHPFVGRDSVEAVNELGEIILVVEMSHPGALEFINPLTDKFIELANDVEPFGVIAPGTRPERVKYIRERLKEGVKILTPGIGAQGGKAKEAIEAGADYVIVGRSIYNAPNPREAAREIYDEIRGE
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: CYAC3_MOUSE
Sequence: MASGWFYLSCMVLGSLGSMCILFTAYWMQYWRGGFAWDGTVLMFNWHPVLMVAGMVVLYGAASLVYRLPSSWVGPRLPWKVLHAALHLLAFTCTVVGLIAVFRFHNHSRIAHLYSLHSWLGITTVVLFACQWFLGFAVFLLPWASQWLRSLLKPLHVFFGACILSLSITSVISGINEKLFFVLKNATKPYSSLPGEAVFANSTGLLVVAFGLLVLYVLLASSWKRPDPGALTDRQPLLHDRE
What is the function of this protein?
Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome (PubMed:16911521).  Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters (Probable).  It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis (Probable).
What are the official names of this protein?
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3, Cytochrome b ascorbate-dependent protein 3, Cytochrome b561 family member A3, Lysosomal cytochrome b, LCytb.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein: MDH_HELHP
Sequence: MFEKIAIIGGSGNVGSHIAFLGAMRHIAKEILLFSNDIPRCKGVGLDISQAAAIFDIPILIKGCNSYEEIAESEVVIITAGFPRTPNMTRNDLLLKNASIIQEISSNVARIAPQSLLIVVSNPLDAMCLVAKQWSKFEKERVIGMAGILDSARLTYESKVMLGDFNKHIQSYVIGSHSDDMLPLLRHCLCEGKVFTDIFTPKMQEELIKETKGGGAKIVNYYQKGSAYFAPASGVIKILEAISTLNEEILVCSVFTEGEYGIKDIYLGLPIKLGKKGVEHIVELPLNQQEQEMLNISTQGIKEQVEILKDNKLLY
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily.
Protein: RSXC_SALTY
Sequence: MLKLFSAFRKDKIWDFDGGIHPPEMKTQSNGTPLRQVPLAPRFVIPLKQHIGAEGELCVSVGDRVLRGQALTRGRGRMLPVHAPTSGTVIAIAPHSTAHPSALAELSVIIDADGEDRWIEREGWSDYRAHSREALIERIHQYGVAGLGGAGFPTGVKLQGGGDKITTLIINAAECEPYITADDRLMQDCAAQIVEGIRILAHILQPREVLIGIEDNKPQAISMLRAVLADAHDISLRVIPTKYPSGGAKQLTRILTGKQVPHGGRSSDIGVLMQNVGTAYAVKRAVIDGEPITERVVTLTGEAVSRPGNVWARLGTPVRHLLNDAGFCPSADQMVIMGGPLMGFTLPWLDVPVVKITNCLLAPSVTEMGAPQEEKSCIRCSACADACPADLLPQQLYWFSKGQQHDKATAHHIADCIECGACAWVCPSNIPLVQYFRQEKAEINAIRLEEKRAAEAKARFEARQARLEREKAARLARHKSAAVQPAAKDQDAIAAALARVKEKQAQATQPVVIQAGSQPDNSAVIAAREARKAQARAKQAAHPMADSAIPGDDPSKAAVEAAIARAKARKQEQQAGSEPAEPVDPRKAAVEAAIARAKARKQEQQAGSEPVEAVDPRKAAVEAAIARAKARKQEQQTGSEPAEAVDPRKAAVEAAIARAKARKQEQQTGSEPAEPIDPRKAAVEAAIARAKARKQEQQAGSEPAEPADPRKAAVAAAIARVQAKKAAQQQVVNED
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rsx electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LRWD1_MOUSE
Sequence: MAPLTPQLLLQRGRPKTDKLGKIQSLNLSGLQLLSEHLDPNLLGRLKKLRELDLSNNLLETLPANLGLSHLRILRCTNNQLGDVTALHQFPELEELNLEGNPFLTVSDNLKVSFLLPKLRKVNGKDTASTCSQVENLDRELMDRVTAHWQKFIATVSPEEETDKVRADFMRSAVRDVCYGPESLIEFTQWRVRMIAEELVASGGAQVQDAKVPVEHPQAAGASKFRAREVASKRPGKDPVTLPPSKRVRALPPAQAEGSPMGADGGQAALHLEPLHFLQCHSRNNSPKDLETQLWACAFEPAREEGHSRATSQTVATCGGEAVCVIDCQTGLVLHKYKVPGEEFFSVAWTALTVVTQAGHKKRWNMLAAAGLRGMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHETHLFTASYDKRIILWDIGVPNQDYKFQASQLLTLNCGSVPLRLCPVATCPDDFLLAGCEGGCYCWDVRLDQPQKQRVCEVNFIFSEDSKVSGQRVDGLAFVNEDVVASKGSGQGTIYLWSWSQTWAGRGRQSVLPVVILVRLQWSPTNLAYFSLSTCPGKNLVLCGDEEGSVWIYDVEHLLKEPPQATTLQPPTQILKWPQPTALGQPVTKTMINTVVANAAFTYLTALTDSNIVSIWRRC
What is the function of this protein?
Required for G1/S transition.  Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells.  Binds a combination of DNA and histone methylation repressive marks on heterochromatin.  Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity).  Required for silencing of major satellite repeats.  May be important ORC2, ORC3 and ORC4 stability.
What are the official names of this protein?
Leucine-rich repeat and WD repeat-containing protein 1, ORC-associated protein, ORCA, Origin recognition complex-associated protein.
What is the protein family that this protein belongs to?
Belongs to the LRWD1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.
Protein: ARGB_ACIAC
Sequence: MTDLQSIAPRDKAEILAQALPYIRKFHGKTIVIKYGGNAMTDPALQADFAEDVVLLKLVGMNPVVVHGGGPQIETALKRLGKQGHFIQGMRVTDAETMEVVEWVLAGEVQQDIVGLINQAGGKAVGLTGRDGGLIRARKLKMVDKDDPSKEHDIGQVGDIVSIDPSVVKALQDDAFIPVISPLGFGEENESYNINADVVASKLATVLKAEKLMMLTNIPGVLNKSGALIPELTAREIDELVVDGTISGGMLPKIAGAIDAAKSGVNAVHIVDGRVPHAMLLEILTEQAYGTMIRSH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INF2_HUMAN
Sequence: MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ
What is the function of this protein?
Severs actin filaments and accelerates their polymerization and depolymerization.
What are the official names of this protein?
Inverted formin-2, HBEBP2-binding protein C.
What is the protein family that this protein belongs to?
Belongs to the formin homology family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.
Protein: RBT1_CANAL
Sequence: MRFATAQLAALAYYILSTEATFPLLGDIFNCIPHNTPPVCTDLGLYHDSSISLGGSKNKREAEIANKDGTIEKRTFGSAGVNAGFNAAFVVSNAKKLSDGSYGIDCNFKSDSSVQLNSAFGKKVKQLSITGTGYSDISLLGNVANPFEWSASLKVKAEIVKGKCCLPSGFRIVTDFESNCPEFDAIKQFFGSSQIIYKVNAVSNAIGTFDASALFNAQVKAFPAKRELDEFEELSNDGVTHSKRTLGLLLGLLKKVTGGCDTLQQFCWDCQCDTPSPSTTTVSTSSAPSTSPESSAPSTTTVTTSSSPVTSPESSVPETTTVTTSSVPETTPESSAPETTTVTTSSVPSTTPESSAPETTPESSAPESSVPESSAPETTPESSAPESSVPESSAPETETETTPTAHLTTTTAQTTTVITVTSCSNNACSKTEVTTGVVVVTSEDTIYTTFCPLTETTPVPSSVDSTSVTSAPETTPESTAPESSAPESSAPESSAPVTETPTGPVSTVTEQSKTIVTITSCSNNACSESKVTTGVVVVTSEDTVYTTFCPLTETTPATESASESSAPATESVPATESAPVAPESSAPGTETAPATESAPATESSPVAPGTETTPATPGAESTPVTPVAPESSAPAVESSPVAPGVETTPVAPVAPSTTAKTSALVSTTEGTIPTTLESVPAIQPSANSSYTIASVSSFEGAGNNMRLTYGAAIIGLAAFLI
What is the function of this protein?
GPI-anchored cell wall protein required for mating efficiency, biofilm formation, and virulence.  Involved in normal disseminated infection, but not in intestinal colonization.
What are the official names of this protein?
Cell wall protein RBT1, Repressed by TUP1 protein 1.
What is the protein family that this protein belongs to?
Belongs to the HWP1 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Protein: MTGA_YERPE
Sequence: MISVRRGFSQLWYWGKRGVIGIIALWMAGILIFAFLPVPFSMVMIERQLGAWLTGDFAYVAHSDWVPMDEISPYMALAVMAAEDQKFPDHWGFDVGAIESALSHNQRNQKRIRGASTLSQQTAKNVFLWDGRSWVRKGLEVGLTAGIELIWTKRRILTVYLNIAEFGNGIFGVEAAARHFFNKPASKLSASEAALLAAVLPNPLRFKVNAPSGYVISRQQWILRQMHQLGGKTFLQENTLD
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NECA1_HUMAN
Sequence: MEDSQETSPSSNNSSEELSSALHLSKGMSIFLDILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNESRYMIYEFWENSSVWNSHLQTNYSKTFQRSNVDFLETPELTSTMLVPASWWILNN
What are the official names of this protein?
N-terminal EF-hand calcium-binding protein 1, EF-hand calcium-binding protein 1, Neuronal calcium-binding protein 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_GEOKA
Sequence: MLDVKILRTQFEEVKEKLMQRGGDLTNIDRFEQLDKDRRRLIAEVEELKSKRNDVSQQIAVLKREKKDAEPLIAQMREVGDRIKRMDEQIRQLEAELDDLLLSIPNVPHESVPIGQSEEDNVEVRRWGEPRSFSFEPKPHWEIADRLGLLDFERAAKVAGSRFVFYKGLGARLERALINFMLDIHLDEFGYEEVLPPYLVNRASMIGTGQLPKFAEDAFHLDSEDYFLIPTAEVPVTNLHRDEILAADDLPIYYAAYSACFRAEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYDELEKLTRQAETILQRLGLPYRVVALCTGDLGFSAAKTYDIEVWLPSYGTYREISSCSNFEAFQARRANIRFRRDPKAKPEYVHTLNGSGLAIGRTVAAILENYQQEDGSVIVPEALRPYMGNRDVIR
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_COXBU
Sequence: MLDPKILRQNLEHVVEKLRRRGFEMDSDTFLQLENKRKEAQLAIQSFQTKRNQLSKTIGMAKSKGENPELLMAEVSQLNDELKQEEANFETIQKAFSDFQLAIPNLPHDSVPDGKSENDNREIRQWGAPPGFDFTPKDHTVLGERDNQLDFEAAAKLSGARFVVLRGSLARAHRALAQFMLDLHTDQHGYEEVYVPYLVHEECLYGTGQLPKFREEQFQVAGDRNFFLVPTGEVPLVNLARDEIIEAPALPKKWVAQTPCFRSEAGSYGKDVRGMIRQHQFQKVELVQLVQPENSYQALEEITRQAEKVLQLLALPYRVVELCAGDLGFAAAKTYDLEVWLPSQNKYREISSCSNCEDFQARRIQARWRNPKTGKPELLHTLNGSGLAVGRTLVAVMENYQQADGHIRVPDALKSYMGGVDYF
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.