PharMolix/UniProtQA huggingface dataset:
Protein: EFG_ACIAD
Sequence: MARQTPISNYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTCFWSGMGNQFAQHRINVIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWRQANKYKVPRLAFVNKMDRTGANFFRAVEQVKTRLGGNPVPIVVPIGAEDTFAGVVDLIEMKAIIWDEASQGMKFEYADIPADLVDTSNEWRTKMVEAAAEASEELMDKYLEEGDLSKEEIIAGLRARTLASEIQVMLCGSAFKNKGVQRMLDAVIEFLPSPTEVKAIEGILDDKDETKASREASDEAPFSALAFKIMNDKFVGNLTFVRVYSGVLKQGDPVYNPVKSKRERIGRIVQMHANERQDLDEIRAGDIAACVGLKDVTTGDTLCDEKNIITLERMEFPEPVISLAVEPKTKADQEKMSIALGRLAKEDPSFRVRTDEESGQTIIAGMGELHLDIIVDRMKREFGVEANIGKPMVAYRETIKKSVEQEGKFVRQTGGKGKFGHVYVRLEPMDVEEAGKEYQFAEEVVGGTVPKEFFGAVDKGIQERMKNGVLAGYPVVGIKATLFDGSYHDVDSDELSFKMAGSYAFRDGFMKADPVLLEPIMKVEVETPEDYMGDIMGDLNRRRGMVQGMDDLPGGTKAIKAEVPLAEMFGYATQMRSMSQGRATYSMEFAKYAETPRNVAEGIIAKFQSGGKKGDDE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAGBG_MOUSE
Sequence: MSQSSEECAADQGQTCEETQKLQVAAASIDVEEPCSSPHLMATSLKDQTSEETQVSKDVEEPCSSSQLLMASDQDDSEDETASTSSDLQHPYDSSSESTEDLDDQEVQGSPVIPPDQSDSTDLPVMTVDGKVDFLVNYMLYKYQVKEVMSMNDIMTLIVREDEDRFHEILMRASERMEMVFGLDVKEVDPINHCYALFIKLGLTYDGMRNDEYSFPKTGLLILILGVVFMKGNRATEEEIWEVLNPMGIYAGMTHFMFGDPRELITDEFVREQYLEYQPIANSDPIQYEYVWGLRAKAETSKMRVLEFVAKVHGSDPTVFLSQYEEALIEEEERTLTMLLEHADSSSTSGESSSDTSSNFSQV
What are the official names of this protein?
Melanoma-associated antigen B16, MAGE-B16 antigen.
Protein: YL101_MIMIV
Sequence: MAFETSTDSFGNTFLKCISCTFDIDSLYNQTETVKKPNKGIIFVGFDDTIITQLNSVYYNRDIIYLTTNNGENYHLMINNSSCPQFCDKTIRASGVSVVLKQGESYYSLLMKDRTKKILTCIGGVCTQSEYKSNPDYSLMVVKRELKEETQGIVEVVSRKLQGETQGFVEIGTDKIYCSGIVLSNSDQLDIIAQAEFLSVYYGLKVPDFYTCYKHTINTSDLYDKFRVFVGLMFDDRNRLPNGDYQLNYLDNSETEYIYAIKLSDNIITTETHNFQTVMNNISDQTSKIDLNGSRISNLHMFFNYLHLKSITENSESLSHEFSDPEMFSKLKLHPSLKKLSYKW
What are the official names of this protein?
Uncharacterized protein L101.
Protein: YJR1_YEAST
Sequence: MLQSIVLSVCMFMLHTVAASGPQSYQKLDFTNVGFTGSYVDVNKFKDITNNESCTCEVGDRVWFSGKNAPLADYLSVHFRGPLKLKQFAFYTSPGFTVNNSRSSSDWNRLAYYESSSKTADNVTFLNHGGEASPCLGNALSYASSNGTGSASEATVLADGTLISSDQEYIIYSNVSCPKSGYDKGCGVYRSGIPAYYGYGGTTKMFLFEFEMPTETEKNSSSIGYYDLPAIWLLNDHIARTSQYPTNANCSCWASGCGEYDIFEAMNGTEKNHLYSTFHTFQGIEDLGTGIQSYGYITRNTTGTMKGGVVFDSSGNVVSFISDATPFNGTVSADTVNDLLAAIPENETYSSQLMSISATAPSTTSKSNGVALTKMQNGVWYYILAIFTAFTQVVLI
What are the official names of this protein?
Cell wall protein YJL171C.
What is the protein family that this protein belongs to?
Belongs to the PGA52 family.
Protein: CA1P_ARATH
Sequence: MISLPLTTPILPSRCLLHKTRRQNSTRRRLLIRSSSSLQDQFTVETTKRVVLVRHGQSTWNEEGRIQGSSDFSVLTKKGESQAEISRQMLIDDSFDVCFTSPLKRSKKTAEIIWGSRESEMIFDYDLREIDLYSFQGLLKKEGKEKFGEAFKQWQEDPANFIIDGHYPVRELWSRARSCWPGILAHESKSVLVVAHNAVNQALLATAIGLGTEYFRSLLQSNCGVSVLDFIPRADGGSPHVCLNRLNQTPNSPLAGGSSGGRKASKQIILVCHGQGNNEDSAVINQAANNDQAMNMLGVIHSQKTAELLLDLRVSSIVCSPKTASIESSGVISRVQEAAGCLGVDNVPHYVKTKQMNELDVESVLRKSNKDNDVIASQLDEEAFSALWNRSEKAWESLLDELSDEKSNPGEIMVVVGPAMTHISLIAQCLNLTKEALGLFHLDAGSISVIDFPDGPSSKGVIRCTNYTAHLGRWSIPITKPA
What is the function of this protein?
Phosphoglycerate mutase-like protein lacking PGM activity, but having 2-carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase activity.  Prevents the accumulation of D-glycero-2,3-pentodiulose-1,5-bisphosphate (PDBP) a potent inhibitor of ribulose-1,5-bisphosphate carboxylase (RuBisCO).  PDBP is produced during the oxidation of ribulose-1,5-bisphosphate, the substrate of RuBisCO.
What are the official names of this protein?
Probable 2-carboxy-D-arabinitol-1-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family.
Protein: SUBC_METRA
Sequence: MPTSANKVETAWSALLAGAAETRQEHLAPSPLFILRQTLFCVLAAYLFCGAGMVWNDWIDRDIDANVARTKNRPLASGKVTTAQAFVWMALQVIASCAVLHVMLDGKDV
What is the function of this protein?
Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of the immunosuppressants subglutinols, meroterpenoids consisting of an alpha-pyrone (4-hydroxy-5,6-dimethyl-2-pyrone) moiety attached to a decalin core fused to a five-membered cyclic ether carrying a prenylside chain (PubMed:27189118).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase subA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (PubMed:27189118).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase subD through the action of the prenyltransferase subC to yield a linear alpha-pyrone diterpenoid (PubMed:27189118).  Subsequent steps in the subglutinol biosynthetic pathway involve the decalin core formation, which is thought to be initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase subE (Probable).  The following cyclization cascade would be catalyzed by the terpene cyclase subB (Probable).  Lastly, the FAD-dependent dehydrogenase subF probably catalyzes the five-membered cyclic ether formation to complete the formation of subglutinol A (Probable).  Subsequent redox reactions appear to give rise to subglutinol C and D, however, it remains unclear which enzymes are responsible for these transformations (Probable).  SubD may have secondary function in the conversion of the identified subglutinols to subglutinol analog 45, which seems to be the major product of the cluster (PubMed:34863012).
What are the official names of this protein?
Polyprenyl transferase subC, Subglutinol biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PLSY_SYNSC
Sequence: MIQTAFTALLLLAIGYLLGAIPSGYLAGRWLKGIDLRDCGSGSTGATNVLRNVGKGPALVVFLIDVGKGALAVLLAKSVGLNDWLQVLTGLAALAGHIWPVWLGWKGGKAVATGLGIFLGLAWPVGLACFGLFMAVISIFRIVSLSSVVAAIGLPLLMLLSGSSSAYVVVSLVASLMVLWRHRSNIERLLAGTEPKIGAKAKG
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COAX_SYNP6
Sequence: MSRLVLAIGNSRWHWGIFSRDQAPQFWDAIAPHQPFSRSDLATFLQAQDPAIVADTPIAIASVVPQQLALLPEDWPQRRLQLRDVPLTNCYPQLGLDRAIALYEAGCQAGWPVLMIDCGTAITINAGDAEGQFAGGAILPGVTLQLRSLAQGTAALPSVEISAEGDRWGMDNQSAIASGVIYGIAGALRGFIEDWRSHHPQRPIYFTGGDGELLAKLLTDLPDIRVEPHLLLHGIDRLAQAMMTDPD
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_YARLI
Sequence: MESLVRQSKKLCPYIGRTSASSLKQLGNGRLTQKAGQCPIMGKAMGVRGFKSDAGSNAESATVDVHAAVDTSKGTCPHAAQYSPVYPSSRLDNYPFGMTQRGLGKVPTQDAHNATTFNYESFYENKINAKHQDKSYRYFNNINRLAAEFPRAHRGSIEEDKVTVWCANDYLGMGRNPVVVDAMHETLDKYGAGAGGTRNIAGHNRHAVELEAAIADLHKKEAALVFSSCYVANDSTLSLLGQALPNCVYFSDASNHASMIHGIRHGGSEKVVWKHNDLADLEAKLARYPKSTPKVIAFESVYSMCGSIGPIEEICDLADKYGAITFLDEVHAVGMYGPTGAGVAEHLDFEHYHSGAQTQRQPIMDRVDIFTGTLGKAYGCVGGYIAGSAKFVDMVRSYAPGFIFTTTLPPATMAGARAAINYQKATMKDRVAQQTHTRYVKDKLANRGIPVVPNPSHIVPVLVGDAQKAKAASDLLLTKHQIYVQAINFPTVPIGQERLRVTPTPGHHEGLCDELVAALEDVWQELDLKRVEDWTAEGGLCGVGEGVEVEPLWSEEQLSYGRD
What is the function of this protein?
Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
What are the official names of this protein?
5-aminolevulinate synthase, mitochondrial, 5-aminolevulinic acid synthase, Delta-ALA synthase, Delta-aminolevulinate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CNSC_PENEN
Sequence: MKLAPAFPRSYFMGRFWAGNTTGDGLEQTWLDGYYRYTKRGKVFARKTELNNWSLIFPSELSHDWRNLPLDQISFQHWAQEGGKIKHHTVLTKAHSKVALLFAKKELLLAVQKILVKETLSLLPGIIGDKWVSLDLMQVCSDLVIKLNARILYGPAYADDQDFHKRLITFANGVDGINSIYFTWPRSLWKIVSLVHPTIRGFYANLPHLKKRMLPDIRSRIAKLQAKAAQGEGKVPASDEDVTFMTALIKMHMEEGTLGEQDSDLEKVCMEAVFYTYEFWGPIMPTLFFMLMAIGKNPGYLQALREEISSALESNDWSSDFLARTPKLESFIREVLRLYVPAQWLITDIHRASLATVSRRTEKPIYVQSMDMHIPAGVNLCVPAKYIHRDPDFYPNPTTFDGFRFYDPVTNNVTIRATTATDTYLSFSHGSGLCPGRVFGAHVVQVLCAVFIMEYDVKVDPSKTFPDVQSTKEGRGDGMVGTTDILIRKRTSAKV
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals (PubMed:25571861).  Communesins are biosynthesized by the coupling of tryptamine and aurantioclavine, two building blocks derived from L-tryptophan (PubMed:25571861).  The L-tryptophan decarboxylase cnsB converts L-tryptophan to tryptamine, whereas the tryptophan dimethylallyltransferase cnsF converts L-tryptophan to 4-dimethylallyl tryptophan which is further transformed to aurantioclavine by the aurantioclavine synthase cnsA, probably aided by the catalase cnsD (PubMed:25571861).  The cytochrome P450 monooxygenase cnsC catalyzes the heterodimeric coupling between the two different indole moieties, tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacyclic communesin scaffold (PubMed:26963294).  The O-methyltransferase cnsE then methylates the communesin scaffold to produce communesin K, the simplest characterized communesin that contains the heptacyclic core (PubMed:25571861).  The dioxygenase cnsJ converts communesin K into communesin I (PubMed:25571861).  Acylation to introduce the hexadienyl group at position N16 of communesin I by the acyltransferase cnsK leads to the production of communesin B.  The hexadienyl group is produced by the highly reducing polyketide synthase cnsI, before being hydrolytically removed from cnsI by the serine hydrolase cnsH, converted into hexadienyl-CoA by the CoA ligase cnsG, and then transferred to communesin I by cnsK (PubMed:25571861).  Surprisingly, cnsK may also be a promiscuous acyltransferase that can tolerate a range of acyl groups, including acetyl-, propionyl-, and butyryl-CoA, which lead to communesins A, G and H respectively (PubMed:25571861).  The roles of the alpha-ketoglutarate-dependent dioxygenases cnsM and cnsP have still to be determined (PubMed:25571861).
What are the official names of this protein?
Cytochrome P450 monooxygenase cnsC, Communesin biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: HGD_BORBR
Sequence: MSLQYQTGFGNACATEALPGALPAGRNSPQICPYGLYAEQLSGTAFTAPRAENRRSWLYRIRPGVQHLPFAPFAGAQRWLSDFGRQPVTPNQLRWSPLPMPDAPTDFIDGMHTWGGNGGPEEQSGVGIHLYAANRSMQGRFFYNADGEMLIVPQQGRLRLATELGLIDIEPYEIAVVPRGVRLRVELLDDVARGYMLENFGTAMRLPELGPIGSNCLANARDFQIPVAWYEDVEGDFELIAKFTGGFWRAPIAHSPLNVVAWHGTHAPYKYDLRNFNTVGSISYDHPDPSIFTVLTSPSDTPGTANMDFAIFPPRILAMENTFRPPWFHRNIASEFMGLIHGVYDAKAEGFAPGGASLHNCMSGHGPDADTFEKASHADTSQAHYIRDTMAFMFETRRVIRPTAQALASPQRQDDYYQCWQGLQKHFDPEQA
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: Y1738_PHOPR
Sequence: MQIWVDADACPNVIKEILFRVANRVGIMVTLVANHHIRVPPSPHIRSTQVLAGFDVADDHIVQQAEPGDLVITADIPLADELITNGVHALNPRGELYTKDTIKQRLQMRDFMETMRSSGVQTGGPPPLNQGDRQNFANKLDTFLVKNFKK
What are the official names of this protein?
UPF0178 protein PBPRA1738.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: CH10_STRPG
Sequence: MLKPLGDRVVVRFDDEKEQTVGGFVLAGTHKESTRKATVLAVSETGVRTITGDSVLPSVSVGQEVLVENGHDLEVTVDDEKVSIIRESDIIAIVTK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETR2_ORYSJ
Sequence: MPPIPSLWIRVFFSWLLLSLPAAAAADFSHCGGCDDGDGGGGIWSTDNILQCQRVSDFLIAMAYFSIPLELLYFATCSDLFPLKWIVLQFGAFIVLCGLTHLITMFTYEPHSFHVVLALTVAKFLTALVSFATAITLLTLIPQLLRVKVRENFLRIKARELDREVGMMKRQEEASWHVRMLTHEIRKSLDRHTILYTTMVELSKTLELQNCAVWMPSESGSEMILTHQLRQMETEDSNSLSIAMDNPDVLEIKATKDAKVLAADSALGIASRGKLEAGPVAAIRMPMLKASNFKGGTPEVMETSYAILVLVLPEDGSLGWGEEELEIVEVVADQVAVALSHAAVLEESQLMREKLAAQHRDLLRAKHETTMATEARNSFQTAMYDGMRRPMHSILGLVSMMQQENMNPEQRLVMDAIVKTSSVASTLMNDVMQTSTVNREYLSLVRRAFNLHSLVKEAISVVRCLTGCKGIDFEFEVDNSLPERVVGDEKRVFHIVLHMVGTLIQRCNAGCLSLYVNTYNEKEERHNQDWMLRRANFSGSYVCVKFEIRIRESRGNLLSSSSSRRLQGPNSTSSEMGLSFNMCKKIVQMMNGNIWSVSDSKGLGETIMLALQFQLQHVTPVSGASSDLFRSAPIPNFNGLQVILVDSDDTNRAVTHKLLEKLGCLVLSVTSGIQCINSFASAESSFQLVVLDLTMRTMDGFDVALAIRKFRGNCWPPLIVALAASTDDTVRDRCQQAGINGLIQKPVTLAALGDELYRVLQNN
What is the function of this protein?
Ethylene receptor related to bacterial two-component regulators.  Acts as negative regulator of ethylene signaling.  May delay the transition from the vegetative stage to the floral stage by up-regulating GI (GIGANTEA) and RCN1 and cause starch accumulation in stems by down-regulating the alpha-amylase AMY3D.
What are the official names of this protein?
Ethylene receptor 2, OsETR2, OsPK1.
What is the protein family that this protein belongs to?
Belongs to the ethylene receptor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GCSPB_NITMU
Sequence: MLIFEHSRPGRRNYSQSPKAAEATDIPEKLLRKTLPLLPEVSEMDAVRHYTRLSQKNFSIDTHFYPLGSCTMKYNPRACNSLAMLPQFLARHPRSPESTGQGFLACMYELQEILKDVTGMAGVSLTPMAGAQGELIGIAMIRAYHESRGDTARTEIIVPDAAHGTNPATAVMCGYKVVEIATDKEGNVDMAALKAAVGPKTAGLMLTNPSTLGVFEENVAEMSRIVHQAGGLLYYDGANLNAILGKVKPGDMGFDVIHINLHKTFSTPHGGGGPGSAPVGVAPRLLPFMPVPIVAFENGTYRWQTEKDIPQSIGRLSAHMGNAGVLLRAYVYVRLLGAEGMHRVAEFAALNANYLMAELRKAGFEIAYPNRRASHEFIVTLKDLKEKTGVTAMNLAKRLLDKGYHAPTTYFPLLVPECLLIEPAETESKETLDAFVTAMKEILEETRTQPDLVKSAPHTTPVRRLDDVKAARELDLAWKAPTRNITRTETLTPIPTVSVA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: V250_FOWPN
Sequence: MDRNINLPEEELKYIKECCEVLYLPQPTRMDIIGVMNDSDISWNENLIILMSEDGKIYVYDDEALYKVADTMEEFSEIGLINLGNEVYHCREDIKPLPEEDRDKDEYIMKIREKARQLIDNSQKDFEAILDSLENKHVSI
What are the official names of this protein?
Uncharacterized protein FPV250, BamHI-ORF4.
Protein: RNPH_NEIG1
Sequence: MPDYIRTSRAADSLRDIKITPHFLPHTDGSCLIECGNTKVICTASVDENAPPFLHGKNQGWVTAEYGMLPASTALRMRREASAGKQSGRTQEIQRLIGRSLRAVVDMEKLGERQILIDCDVIQADGGTRTASITGAFVALQIAVGKLVSDGILSENPILEAVAAVSAGVVNGVPLLDLDYPEDSGCDSDVNIVMTASGKIIEIQGTAEGAPFSLDELGKLVALAQKGIGELLRYQQNALSVA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: INH9_TABYA
Sequence: MTSNLYYVLISPYSLAYMVQYRSVTTAAGECRGDMWAVCARISSDVTCARHANLQRSIRRCFYIRSTMCEIMLLRDHGDYPVASRMKVIVWDEELAALAKRHTQGCVPEAYKCRHTLRFWTPGQLNFEFYADKMPFTMSLISTAIKRGHMQKHNITRDIVEKYQPVGPKGNVKELALAIFDRVTAVGCGLTTWKLGGKARAFFTCNFFSENDYNRPVYKTGNSPGEKCIKKDETFKNLCFAQEPINPNEHNL
What is the function of this protein?
Inhibits platelet aggregation induced by all agonists tested (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and snake venom snaclecs (TMVA that activates platelet through GPIB, and stejnulxin that specifically acts through GPVI (GP6))) (By similarity).  May act by competing with fibrinogen for binding to glycoprotein IIb/IIIa (ITGA2B/ITGB3) (By similarity).
What are the official names of this protein?
Tabinhibitin 9.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: HN1BA_DANRE
Sequence: MFANMVSKLTSLQQELLSALLDSGVTKDVLLQALEDLDPSPSAFGVKLDSLQMSPSGSKLSDTDSKPVFHTLTNGHSKGKLSGDEGSEDGDDYDTPPILKELQSQNTEEAAEQRAEIERMLAEDPWRAARMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQATQGSGATMLDKGNQDQVLLFFSEFSQSGQGMVQPGDDAAIEPACKKLRRNRFKWGPASQQILYQAYERQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSGPAHSLNSLLSHSSPHHPQTSSSPPSKMQGVRYSQQGPGEVTSSTTINHHSSNAMSTSQSVLQQVSPGALDPSHSLLSPDAKMISVSGGGLPPVSTLTNIHASHHVHQQTPNLIMPLSGVMAIAQSLNTSQAQTVPVINSVAGSLAALQPVQFSQQLNSQHQQLMQQSSGHMSQQSFMASVSHSHMYPHKQEPPQYSHSSRFPPAMVVTDANSLSTLSSMSSSKQCPLQAW
What is the function of this protein?
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity).  Required for induction of rhombomere r5/r6 gene expression in the hindbrain.
What are the official names of this protein?
Hepatocyte nuclear factor 1-beta-A, HNF-1-beta-A, HNF-1B-A, Hepatocyte nuclear factor 1-beta-2, HNF-1B-2, Transcription factor 2, TCF-2, Variant hepatic nuclear factor 1, vHNF1.
What is the protein family that this protein belongs to?
Belongs to the HNF1 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIPM_BACVZ
Sequence: MEKETWRFIDSGNESPAFNMALDEALLYWHSQKKIPPVIRFYGWNPATLSVGYFQNIKKEINFDAVHKHGLGFVRRPTGGRGVLHDKELTYSVIVSEDHPEMPATVTEAYRVISEGILQGFRNLGLDANFAIPRTEKEKESLKNPRSSVCFDAPSWYELVVEGRKVAGSAQTRQKGVILQHGSILLDIDEDKLFDLFLYPSDRVRERMQRNFKNKAVAINALAPKRVTMDEARIAFKAGFEEGLNIHLEPYTLTSEELAFVNELAETKYASDEWNYKR
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation.
What are the official names of this protein?
Octanoyltransferase LipM, Octanoyl-[acyl-carrier-protein]:[GcvH] N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the octanoyltransferase LipM family.
Protein: SYI_COXB2
Sequence: MTDYKDTLNLPQTDFPMRANLPEREPQTLARWQTLDLYRKIRKDREGQPKFILHDGPPYANGRAHLGTAFNKTLKDIVVKSKTLSGFDAPFVPGWDCHGLPIELNVEKKLGKDKLSANAFRQACRDYAFSQIELQRDDFQRLGVLGDWQHPYLTMDFGYEADTVRALAKIVANGHLLRGQKPVHWCAACGSALAEAEVEYRDKASPAVDVGFEAVDAEAVRQRFGVKNATTRVLVPIWTTTPWTLPANEAVSVHPELHYALVKSELQNQPVYLILAKDLVDSAMQRYGVDDYEVHGNLKGDALEGMQLQHPFLDRIVPIILGEHVTTEAGTGNVHTAPAHGLEDYFVAEKYNLPINNPVDARGRFIPDTFLVGGQPVFKANEPIIVLLADSGHLLHSETIQHSYPHCWRHKTPLIFRATPQWFIGMNKNGLRERALAEIEKVTWLPAWGEARIGKMVADRPDWCISRQRLWGIPIPLFIHKKSGELHPKSPALMEKVAQLIEKESVDAWFDLDPKVLLGDDADHYEKVTDVLDVWFDSGVTHFCVLEKRRELKVPADIYLEGSDQHRGWFQSSLLTSLAIRDKAPYKSVLTYGFVVDSQGRKMSKSLGNVILPADVVKNLGADVLRLWAASMDYTVEVNVSDEILKRASDAYRRIRNTARFLLSNLYDFDPKKDKVAVDQLVALDRWAIFTTQKLQEKIITAYDRYRFPAIYQAIHNFCTVEMGSFYLDIIKDRLYTSKESGLPRRSAQTALYYIAEAFVRWIAPIISFTADEIWQFMPGDREPSVFLTQWFSDFPNAALSGEEEQRWQLLLQIRDEVNKALETYRNEGKIGSALTAEVVLYADERLNAAIATLGEELRFVLITSEASVLPFNEKSKAAFDTALPGLALEINVSEFEKCARCWQRRSSVGQIKEHADLCDRCVSNAFEDGDMRQFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I68A0
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRFFEHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).