PharMolix/UniProtQA huggingface dataset:
Protein: P4KG8_ARATH
Sequence: MAVALDPLTDRFSQFSRSSQRCRLQSLTNLDFNFLGFNTKQTNLSASSHSLNNRSVSTPCFSISGSNLDGSATPHIEILGGQRVPTVRSLVAEVTIAIVSGAQPLLLPSGLGGAYLLQTEKGNNIAVAKPVDEEPLAFNNPKGSGGLTLGQPGMKRSIRVGESGIRELAAYLLDHQGFSSVPPTALVRISHVPFHDRGSDHAAYKVASLQRFVGHDFDAGELGPGSFTVVSVHRIGILDVRVLNLDRHAGNMLVKKIHDQDETTCSNGVGAAELVPIDHGLCLPECLDDPYFEWLNWPQASVPFTDIELQYISNLDPFKDAELLRTELDSIQESSLRVLIVCTIFLKEAAAAGLSLAEIGEKMTRDICRGEESSSVLEILCNKAKASAVSGSDDDDDYSSEWNEVEAELECGIFQFDDEVECKELPDMLQVPIFTRVPSIAANLSALMRCPPNQWISTYDTNIEEERRDRSIVRSKSHPICVNYDEKEGVYFGDMSGDEWEMFLHSFQMLLPEALEGSTSKGPKPRFGSSCKF
What is the function of this protein?
The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
What are the official names of this protein?
Phosphatidylinositol 4-kinase gamma 8, AtPI4Kgamma8, PI-4Kgamma8, PI4K gamma 8.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
Protein: YAO_ORYSJ
Sequence: MAPRPRKRVSRPKPRATSRGRGGGDEDPFFESEPKRRRGGGRDEDIESEDSDLEGVAAAAAGGVGDDGEEEEEEEEEQETAGEKKMRIAKELLKKVTDAARRRREDDEDEDEGEEAGRRRVADILLKRQFEESGRKRMELADRILQPDPEDGFKMLVKHRQPVTAVVLSKDSDKGFSASKDGVIVHWDVETGKSEKYLWPSENVLVSHHAKPPLSAKRSKQVLALAVSADGRYLASGGLDRHIHLWDVRSREHIQAFSGHRGAISCLSFGPDSSELFSGSFDRKIMQWNAEDRTYMNCLFGHQNEVLTMDALSKDRLLTVARDRTMHLWKIPEESQLLFRAPATASLECCCFIDDKEFLTGSDDGSVELWSIMRKKPTHIIRNAHPVFRNNLNSLENNVEENGIHKPESVSSAQSWVSAIAARRGSDLAASGAANGSVRLWAIEPDSKGIRPLFSLRLDGFVNSLAIPKSGRFIVAGVGQEPRLGRWGRVRSAQNGVVIHPIRLKEESEDL
What is the function of this protein?
Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (By similarity).  Essential for embryogenesis (By similarity).
What are the official names of this protein?
U3 snoRNP-associated protein-like YAOH, Protein YAO homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RRP9 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: OHRL1_STAEQ
Sequence: MAVQYETKATNVGGRKGHVHTDDNAINVDVLPPQQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAEPEVTLTVRLEDDPDAESPKLSVDIHAKVKNVLSQEDAEKYLQDAHDFCPYSKATRGNIDVNLNVEVVE
What are the official names of this protein?
Organic hydroperoxide resistance protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the OsmC/Ohr family.
Protein: NDB4S_HETPE
Sequence: MKTQFVILLVALVLFQMFAQSEAIFSAIGGFLKSIFGKRGLQDLDMDDLDQLFDGEISQADINFLNQLMR
What is the function of this protein?
Amphipathic peptide with antimicrobial activity.
What are the official names of this protein?
Peptide Hp1035, Non-disulfide-bridged peptide 5.10, NDBP-5.10.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: RL10_MYCPU
Sequence: MHIESKNRQIKKDIVVEITKKINDSQSLFLAEYRGLTVAKLLNLRKEAKKHNVEIKVYKNRLVKLATQKLGHSDLDKFLVGPNLFVFSNELGMDGAKVLAEFAKKNKKLVLKAGIFDGKVVDAAGVKAVAELPTYEEALTILASSLLGPLRQISLSFKLLVDENKLSN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: AP18B_YEAST
Sequence: MSSLYTKLVKGATKIKMAPPKQKYVDPILSGTSSARGLQEITHALDIRLSDTAWTIVYKALIVLHLMIQQGEKDVTLRHYSHNLDVFQLRKISHTTKWSSNDMRALQRYDEYLKTRCEEYGRLGMDHLRDNYSSLKLGSKNQLSMDEELDHVESLEIQINALIRNKYSVSDLENHLLLYAFQLLVQDLLGLYNALNEGVITLLESFFELSIEHAKRTLDLYKDFVDMTEYVVRYLKIGKAVGLKIPVIKHITTKLINSLEEHLREETKRQRGEPSEPQQDRKPSTAISSTSSHNNNSNDKNKSIAQKKLEQIREQKRLLEQQLQNQQLLISPTVPQDAYNPFGSQQQDLNNDTFSFEPTQPQMTAQVPQPTANPFLIPQQQQQALQLTSASTMPQPSEIQITPNLNNQQTGMYASNLQYTPNFTGSGFGGYTTTENNAIMTGTLDPTKTGSNNPFSLENIAREQQQQNFQNSPNPFTLQQAQTTPILAHSQTGNPFQAQNVVTSPMGTYMTNPVAGQLQYASTGAQQQPQMMQGQQTGYVMVPTAFVPINQQQQQQQHQQENPNLIDI
What is the function of this protein?
Involved in endocytosis and clathrin cage assembly.
What are the official names of this protein?
Clathrin coat assembly protein AP180B.
What is the protein family that this protein belongs to?
Belongs to the AP180 family.
What are the subcellular locations of this protein?
Bud. Bud neck. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: RBSD_SYMTH
Sequence: MKKTTLLNQALSEVVAGMGHGDLLVIGDYGLPCPKGVRRIDLALRPGIPAFLDVVETILAELQVEAAVVARETAERNPAVQEGLTRLLGGVPVTTVSHEELKEISARAVALVRTGECTPYANVILRAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPC_SHEEP
Sequence: KSEQSSFSSSSSVRNELSVYHNSRQKPPAEKTNQSSKNIGKKAAPFKKQKRANKGSSGAQVLYAKDSGGAQNESLRSNEADLAKKKNPNPSGDTGSSKNQDSMAAQNVHQKSQMSVETCTTPSKSNLILESLGLQFFGREVTLFRLKNYLTSERHSDVDDNVVQENLNDSRGEIPDSTPESKMHHKLVLPSYTPNVRRTMRTRSKPLEYWRGERIDYQARPSGGFVIGGILSPDTVSSKRKAKGNLGRIITTANRKRICLENAPIKNKFMVNLNIPLGDPLQPTRVKDPETQETVLMDLIRPRDTYQFCVEHDELKVYKTLDTPFFSSGKLIIGPLQEKGKQHVGLDTLVFYVNLGYLLCTLHETPYIVTTGDSFYVPSGNYYNIKNLLNEERVLLFTQIKS
What is the function of this protein?
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.  CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
What are the official names of this protein?
Centromere protein C, CENP-C, Centromere autoantigen C, Centromere protein C 1, CENP-C 1.
What is the protein family that this protein belongs to?
Belongs to the CENP-C/MIF2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes exclusively in the kinetochore domain of centromeres.
Protein: QUEF_SALHS
Sequence: MSSYENHQALDGLTLGKSTDYRDNYDASLLQGVPRSLNRDPLGLTADNLPFHGADIWTLYELSWLNSQGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFDTWETVRQTLERDLRACAQGNVSVRLHRLDELEGQPVAHFHGACIDDQDISIDNYQFTTDYLQHAVSGEKQVEETLVSHLLKSNCLITHQPDWGSIQIQYRGRKIDREKLLRYLVSFRHHNEFHEQCVERIFNDILRFCQPETLSVYARYTRRGGLDINPWRSNTDFVPATGRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS25_DANRE
Sequence: MPPKDSKQKKDAGKSKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLYKEVPNYKLITPAVVSERLKIRGSLARAALQELLGKGLIKLVSKHRAQVIYTRNTKGTDEAAPEKEA
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
40S ribosomal protein S25.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS25 family.
Protein: BOA5_BOTFB
Sequence: MQAVIQTGPGTLQLTENVPKPSVEPGSRKVLVKVHAVALNHSDWKMVDFSAKPGAISGYDMAGVLEAIDDSMNSDLAVGDRVLGVTSIHGGAFAEYVVTDGDLLVKIPENMDFQHAASYGVGIVTTGLALYGNECLALNWPNTDGTGSAAPQKTRVGPRGWSGGDALTDNDNETPRIPVLVYGASTSTGTLAIQLLKLSGYEPIAVCSPHNFGLVQSRGASKCFDYHSQGCGAMIKQYTYNRLEYALDCITTASSMRLCYEAIGATGGKYVSLDPFNARVQRSRADVKPFFCYALTIFGLPIELSGEFARGAKPEDRKLAEKFVKIAEKLIEKGRLKAHPTMLKSGGLGGIASSIDLLRKGKVSGSKLVFDVVGN
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster A that mediates the biosynthesis of botcinic acid and its botcinin derivatives, acetate-derived polyketides that contribute to virulence when combined with the sesquiterpene botrydial (PubMed:18208491, PubMed:21722295).  Botcinic acid and its derivatives have been shown to induce chlorosis and necrosis during host plant infection, but also have antifungal activities (PubMed:18208491, PubMed:21722295).  Two polyketide synthases, BOA6 and BOA9, are involved in the biosynthesis of botcinins.  BOA6 mediates the formation of the per-methylated tetraketide core by condensation of four units of malonyl-CoA with one unit of acetyl-CoA, which would be methylated in activated methylene groups to yield a bicyclic acid intermediate that could then either be converted to botrylactone derivatives or lose the starter acetate unit through a retro-Claisen type C-C bond cleavage to yield botcinin derivatives (PubMed:23203902).  The second polyketide synthase, BOA9, is probably required for the biosynthesis of the tetraketide side chain of botcinins (Probable).  The methyltransferase (MT) domain within BOA6 is probably responsible for the incorporation of four methyl groups (Probable).  The trans-enoyl reductase BOA5 might take over the enoyl reductase function of BOA6 that misses an ER domain (Probable).  The monooxygenases BOA2, BOA3 and BOA4 might be involved in further hydroxylations at C4, C5 and C8, whereas BOA7, close to BOA9, could potentially be involved in the hydroxylation at C4 in the side chain of botcinins (Probable).
What are the official names of this protein?
Trans-enoyl reductase BOA5, Botcinic acid biosynthesis cluster A protein 5.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: NTPPB_XANOR
Sequence: MMPRLILASTSAYRRQLLSRLQLEFDTGRPEVDEQPQSGEAPSALASRLAAEKAAAVAVRLPGAWVIGSDQVADLDGQALGKPGTRAQAQAQLTAMSGRTVRFHTAVSLIGPERELHALDLTEVQLRALTPAEIERYLDAEPALDCAGSFKCEGLGISLFDAIRSQDPTALVGLPLIALARLLREAGFHLP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VEA_COCH5
Sequence: MSNIVVSNETKSQSVRTTKDGRQIRYNLQVIQQPERARACGSGAKSSADRRPVDPPPIVELRVFENDQEITFAYNANFFLHASLENARTIAPGRAPSTAGPSFPVLTGTPVAGMAYLDRPTPAGYFIFPDLSVRHEGKYRLSFALFENLAEVKDLDPEDPDVIYDGNHFVTHRCEVKSAPFTVFSAKKFPGLSESTALSRMVAEQGCRVRIRRDVRMRRRENKSSKEWDEYDEEGGGYDRARGTATPDNYGQAPNAPLGDRPRSLSSASNPALAPPRRPSIEEMGHGYSASNGYQQQMPPPQTPAYAQMPSYGSNQPQYSQQYQTPQPAPMMQPPQPPQHSTPYSQHSQHSSYSSQHQAQPPVPMNQQYGYSNYQQQPQQPQSQSQPQYDHAAPPRQEQMSSDYAHPSDYRRSSITQSPAQQYTASSHPVQPYHPMDQYGRSQQMSQPLHSSPQSYASSAPSHQSLPSLRPIVADKLEPVSPSYQSPPTSMSAAISVNSDGSNQHYALPKFNPQTQGLPPMSATSNKRSFSSTFDSRHLNERMVAGSRPQPSGAGYSYDPGSPDMEEPMDRAAMSYRRADGTQRQRHVPEVGS
What is the function of this protein?
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity).  The velvet complex acts as a global regulator for secondary metabolite gene expression (By similarity).  Controls the expression of the T-toxin gene cluster (PubMed:22383877).  Promotes oxidative stress tolerance and acts as a virulence factors during infection (PubMed:22383877).  Negatively regulate mycelial pigmentation and controls sexual development, as well as asexual development during vegetative growth (PubMed:22383877).
What are the official names of this protein?
Developmental and secondary metabolism regulator VEL1, Velvet complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the velvet family. VeA subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Enriched in the nucleus in the dark (By similarity).
Protein: SUFS_ECO81
Sequence: MTFSVDKVRADFPVLSREVNGLPLAYLDSAASAQKPSQVIDAEAEFYRHGYAAVHRGIHTLSAQATEKMENVRKRASLFINARSAEELVFVRGTTEGINLVANSWGNSNVRAGDNIIISQMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLETLPTLFDEKTRLLAITHVSNVLGTENPLAEMITLAHQHGAKVLVDGAQAVMHHPVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEMPPWEGGGSMIATVSLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVSALGLNNIAEYEQNLMHYALSQLESVPDLTLYGPQNRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAYYNVPAMCRASLAMYNTHEEVDRLVTGLQRIHRLLG
What is the function of this protein?
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation.  Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine.  Selenocysteine lyase activity is however unsure in vivo.
What are the official names of this protein?
Cysteine desulfurase, Selenocysteine beta-lyase, SCL, Selenocysteine lyase, Selenocysteine reductase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR4_SOLTU
Sequence: MSRYRGPRFKKIRRLGALPGLTNKKPRTGSDLRNQSRSGKKSQYRIRLEEKQKLRFHYGLTERQLLKYVRIARKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPAARQLVNHRHILVNGHIVDIPSYRCKPRDIITAKDEQKSRALIQISLDSSPHEELPNHLTLQPFQYKGLVNQIIDSKWVGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CAO2_NEUCR
Sequence: MSPHEVIGTVPKNSTTFRTQADEHDDHEEALQNLRTGKYEDWPNEAAFDGLTEERGPIKIAVTGNIPTWAAGSLYRTGPGLYKIDTDAGTTFEMSHWFDGLAHTHRFDIIPNEEGSVDIFYSSRRQAEEMMDVIKKQGTWPYYSFGQKADPCLGFFAKAMAAFKGLREPSGEKWHNNVNVAVHVNPPGLEAVRNIVGTRKPAVAENDANVLGHRPELPKSIWVSTDNSTMKQIDPQTLEPIGWATQDVLHPELTGAMSCAHAQRDPDTGDFFNFNLEFGPKPTYRVFRVDASSGKTEILATIREPSVSPAYIHSLFLSPSFVILCIPTSHFGLSGTQIPWERNLVDAIKPYDPSRKTQWIVIDRKHSKGVVARFETDGRFFFHTVNSFEEKAGSDSSDINLYCDVIDFGSHEFIHSLYLDVILNRDSAAKKFYEDEQRARNSLAHLTRYHFIINPDSPTTNLPVTPTPDPKNHEAFRIPAPHAGEIPTINPLYATRKHRYVYSLPFRGRGTITDAIVKTDTVTREALFWDNPKGHTPGEAIFIPRPGGEEEDDGVLLSLVLDGEKGKSYLLCLDAKTMAEMGRAEVDFAIALGFHGAHVPSGRTLTRVEGPEY
What is the function of this protein?
Torulene dioxygenase; part of pathway that mediates the biosynthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigments and leading to orange pigmentation (PubMed:17610084).  Cao-2 mediates the cleavage of torulene into beta-apo-4'-carotenal, the aldehyde corresponding to the acidic neurosporaxanthin (PubMed:17610084).  Is not able to use gamma-carotene (that it is not desaturated at the C4'-C5' bond) as substrate, which suggests a high specificity of cao-2 in cleaving the C4'-C5' double bond (PubMed:17610084).  Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities.  Phytoene synthase activity performed by the bifunctional enzyme al-2 first produces phytoene from geranyl-geranyl pyrophosphate (GGPP).  The phytoene dehydrogenase al-1 then introduces 5 desaturations to lead to 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene.  Al-2 cyclase activity then converts 3,4-didehydrolycopene into torulene.  Al-2 can also convet lycopene into gamma-carotene which in turn is converted to beta-carotene by an additional al-2 cyclization reaction.  Torulene is the substrate of the dioxidase cao-2 that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase ylo-1 mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
What are the official names of this protein?
Carotenoid dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
Protein: CYB_PHYMC
Sequence: MTNIRKSHPLMKIINNAFIDLPTPSNISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTTTAFSSITHICRDVNYGWTIRYLHANGASMFFICLYTHMGRGLYYGSYIFQETWNVGMMLLITVMATAFVGYVLPWGQMSFWAATVITNLLSAIPYIGTTLVEWVWGGFSVDKATLTRFFTLHFILPFITLTLTMVHLLFLHETGSNNPTGIPSNMDKIPFHPYHTIKDTMGALLLILSLLTLTLFAPDLLGDPDNYTPANPLNTPTHIKPEWYFLFAYAILRSVPNKLGGVLALLLSILILVFIPMLHTAKQRSMMFRPFSQFLFWTLIMDLLTLTWIGGQPVEHPYVTVGQLASILYFLLILILMPTASLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TRPA_HELPJ
Sequence: MRYQNMFETLKKHKKMAFIPFVTLGDPNYELSFEIVKTLIISGVSALELGLAFSDPVADGTTIQASHLRALKHASMAKNFQLLKKIRGYNHDIPIGLLAYANLIFSYGVDGFYAQAKECGVDSVLIADMPLIEKELVIKSAQKHQIKQIFIASPNASSKDLEQVATHSQGYIYTLARSGVTGASHTLENDASAIIKTLKTFSSTPALLGFGISKKEHITNAKGMGADGVICGSALVKIIEENLNNEDAMLEKIKGFVGGMIS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: GLYA_SALPB
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAQGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDEMAKLAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGDEELYKKLNSAVFPSAQGGPLMHVIAGKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRIGSPAVTRRGFKEAEVKELAGWMCDVLDNINDEATIERVKAKVLDICARFPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDB4T_MESSU
Sequence: MKTQIVILIVAVLFLQLVSQSDAFLKGIIDTVSKLFGKRGLKNLDQYNDLFDGEISDADIKYLQDLMR
What is the function of this protein?
Amphipathic peptide that shows no antibacterial activity even at 50 uM but shows a low hemolytic activity against human erythrocytes.
What are the official names of this protein?
Amphipathic peptide CT2, VsCT2, Non-disulfide-bridged peptide 5.12, NDBP-5.12.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: RHG23_HUMAN
Sequence: MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGSASSSSQESLRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQPPRRSAASRLHQCL
What is the function of this protein?
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
What are the official names of this protein?
Rho GTPase-activating protein 23, Rho-type GTPase-activating protein 23.
Protein: PURA_OSTLU
Sequence: MRGREDANARVLGSQWGDEGKGKLVDILAREYDVVARCQGGANAGHTIYDDDGKKYALHLVPSGILNENATCVVGNGVVVHLPGMFDEIDALLKAGVDARGRMMVSDRAHLLFDLHKEIDGLREAELSGNKIGTTKRGIGPAYASKATRNGVRLGDIRDADKFANALRTLAADAAARFDGFEYDVEAEIVRYREIASRIEPFIADTVEYVNDAHRNGKKILVEGANATMLDLDFGTYPFVTSSNPAIGGVSNGLGLAPRKFETIIGVAKAYTTRVGAGPYPTELFGDVADKLRELGYEYGTTTGRPRRIGWLDMVALNYANQINGFTHLNITKLDVLSEMDELKIGVAYELPNGKTTTAFPADIATLENVKVVYETLPGWKTDIANVRSWDDMPENAKKYILRCEELSGVECRYIGVGPGRDAMVIKP
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, chloroplastic, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.