PharMolix/UniProtQA huggingface dataset:
Protein: RIMO_AKKM8
Sequence: MPLTVGLISLGCPKNLVDSEIMIGHLQKAGMTMTPEPELADVMVVNTCAFIDQAKQEAIDAILDIVRARENGAYPENQKLIVAGCLSQRFRKELPALLPEVDAFIGPDQITKLPEIITQVMDRTIQDRNFIEGKCRYVPDWNTPRYRLTPPHTAYIKIAEGCNHGCAYCIIPMIRGRHRSRSQQDVVREAETLIRSGVKEICLIAQDITYYGMDKWTDARPNRRSAVDSSRGESLASLLRALNAIEGEFWIRLLYTHPAHWSDELTAAIAECPKVARYVDIPLQHISDNMLDAMQRVTDGNYIRTLLRNIRKAVPGIAIRTTFITGFPGETEDDHQELMEFIEEFRFERAGIFTFSREEGTKAYKMPNQVHHRTKARRYNEATLLLARLASETGQEQIGRQIRVLVDAPGVARTEWDAPDIDGTVSVPLTLPVGQFATVTVTDAVAYELTAE
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB_METBF
Sequence: MDNDKYLKGTTTVGVVCTDGIVLASEQRATMGNFIASKTAKKVYQIDDLVAMTTAGSVGDAQQLVRLVNVESQLYKMRRNESMTIKGIATLMSNFLNSNRYYPMMVQLLIGGVDKNGPGIYSLDALGGSIEETRISATGSGSPMAYGVLEDQYREDMTVKEGLDLAIRAIHNATKRDSASGENIDVVVITKEAFRRLDPEEVKSIRASLPK
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PsmB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAN1_CHAGB
Sequence: MYSNPNNFFGGNAMGPGAPQYGAGQPQQQQQQQQQPDPFAPQPTGFAQAPLQQQYTGYPGLQAPQGQLQPQFTGYGQTPQQGMATGAPPMPAIPQQYQQQFQQQQTQQQQPQQQQMPFAAAPPQPTQTLAPPPPVKPQATGFSEMAASFHAGGGARSQPSAAPRKANTVPNIRLSFITAPDQAKFETLFKSAVGDGQTTMSGEKARDLLLRSRLDGDSLSHIWTLADTTRSGQLHFPEFALAMYLCNLKLTGKSLPPSLPDNIKNEVSSMVDIINFSIAEESGSASATSTNAPDFGVRQNTATPPVIQHPQPQPSSSQLLQAQMTGFPAQQTGFMGQGLQPQQTGMPQATGYTGPRPPMPPMPTGFGSNLSPNVGPGGMIAPLNAQPTGRPGQWGLVNTPATGLPNIDALQARMMPQQGREQQDYTTAGLQGNAVIPWAITKDEKTRYDALFRAWDGLNKGYIGGDQAIEIFGQSGLEKPDLERAWTLADHGNKGRLDLDEFAVAMHLIYRKLNGYPIPNQLPPELVPPSTRNFNESLGTIKNMLHKESDFRKNSGASLLPQKTGVSYLKNHSFRGTGGASGNRKDATVFKNNDDAVGYRSSARRRVGNASPRPESPASVGSNEELSLDQLRKKIKEKQVLLDAMDFADEKNMEEDDILDRRDRREAEELYRRIRRIQEDIDNHPDASPIGGDSEAERRALKRQLQNLTDKIPELASQVRKTEKAIADARLELFRLKDAKAHPGSAAAIVGTGPGGAITESDRLKARAKAMMQQRTAALTGKKIDVTSDQDAEKRLEEESIKARTEKENNERMVRDVEDSVRDFAKGIEDNLKEGGQDSTTEHEKRRWEDALGVEDEVRDFIYDLQRSSRASRIRSQDRQGGRKATQEPVSAEAPPTARVDSPASISRTASPAAPPAAGGSYSSYKTPEERAAFIKQQAEQRMAERLAALGIKAPTKPGETAAQRAEREQAERAAKLRQAEEEDARRETERQARLAEEQGVPPPAVSQAAKPEGKKPPPPPSRKAAKPDDRRAEEELATKKAEEERLERERGEQERATRELESQAKAQEDELAKEREEADARLRALEEQVRQGKLKKEEEKRKKKAALAEAKEKEAQLAQRRAEIEAARKREEELRRQLEAMDDDSSSDDEGPEQITPQASTPTMNDSHIVNREPERQPTPPPAPVVSPPQIVTSSPPTEGESRNPYFRMMSHSSDASPATAPAPPVAPPVAPPAPPQPEASTNPFHRIAQAPAPETSPVPVTRRRPDDDGWGSDKDEEDEESDDDRPGGKSAAALASILFGTMAPPRPLSATGDKSATSPTVSSPVAPPPESASPPAASPSAPPPPPPMPGSFPSASPGPGAPPPPPPPPPPMPSAGGPPGAPPAPPPPPPGMAPPAPPPPPPAGGPPAAAPAGGRPAGLLGQIQAGKALKKTTTRDKSAAAVAGRVLD
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein PAN1.
What is the protein family that this protein belongs to?
Belongs to the PAN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: HIS8_BREBN
Sequence: MQPKQRILNAPVYQPGKPIDDVKREFGLTEVIKLASNENPFGSSPKAKAAISEQLDNLALYPDGASLNLRWDLADFLGVKPSQLFFGNGSDEILLMISRAFLSEGTNAVMATQTFSQYRSNGIIEGADLIEVPLKDGVHDLEAMAAAINEQTKVVWVCNPNNPSGTIVTTSELEAFMKKTPKDVLVVLDEAYYEYVVDPEYPQTVPMLAEYPNLIILRTFSKIYGLAALRIGYGIASEELISSLEHVREPFNTGTLGQVAARAALKDQEFVKSCRDRNREGMKQFTDSFDEWGLSYYPSQTNFILVDLKMDSDEVFKKLLSQGIIVRSGNALGFPGFQRITIGTKEQNDKILSVLKEIVTGALK
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: ASSY_BURCJ
Sequence: MSTILESLPTGQKVGIAFSGGLDTSAALHWMKLKGAVPYAYTANLGQPDEDDYDAIPKRAIEYGAAGARLIDCRAQLVAEGIAALQSGAFHITTAGVTYFNTTPIGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQTFIDELGGRAEMSEFMNQAGFAYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVKIAAEEVTVRFEAGQPVALNGVEFNDQVELLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLYIAYERLVTGIHNEDTIEQYRENGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAITGEVKIELRRGNDYSILSTKSPNLTYQPERLSMEKVASTFSPRDRIGQLTMRNLDITDTRDKLRVYSQVGLLTPGEASALPQIKGDGDK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAC3_RAT
Sequence: MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGDLRDVPSAGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSVFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKRYRTDKHRGIIIETEGEHPKGIEMDGKMMNSHFLDGNLIPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTASMSEVHTDEPEDFASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRVEEEQLEEGMTPAILNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPEVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEEEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHVSAGTLAFSVTLFTIFAFVCLSVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYVLFATLEAYCYIKGF
What is the function of this protein?
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8798769, PubMed:9486131).  Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain.  In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum.  SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline.  Contributes to Ca(2+) transport during excitation-contraction coupling in muscle.  In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory.  Required for normal oligodendrocyte differentiation and for normal myelination.  Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis.
What are the official names of this protein?
Sodium/calcium exchanger 3, Na(+)/Ca(2+)-exchange protein 3, Solute carrier family 8 member 3.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell membrane, sarcolemma. Cytoplasm, sarcoplasm. Cell junction. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Detected at neuromuscular junctions.
Protein: QUTR_NEUAF
Sequence: MNNIPARHVGDVAARDPLPLPHKSSSVASGMKRSFATMAMLYANDSDTGNSDDAGSNARRPPRPLSNSPSTSNYRVGSWSAPNSPPRRALPYYPITASFDADASIVVAGIRGAGKSTLAIMASTAMKRKIVDLESEFHHLTGLSSSTYKKRHGPADYGRRQITILQNILNLHRTRAILVCSWLERDVQALLQDFSTSNPVIYVLRDAKAIEAHLKGYDKSKVGTLLDATSAVLRRCTRFEFFNVSEENLDTHSGSASPPAVPDQRHTAPYLTLKRAERHFLKFLSLILPKGTIPFVESAFPLASVPVEQRRFTYALALSISAFLDKGVDIQELDAGVDAIEIIVDDLATSESGPASPLGLAPHRASDISRVVGEIRRDTVIPIILHVVFPERALHEEALLVLYMAYLTHALRLAPDYLTVDLRLDSGLLGQLTAVKGITKVIGNKQLADANSPLWGDPSWLLAYQKAQNTGCDLVRLTRPASNSRDNTDIRQFQVAVEAVGGPRLPFISYNTGRLGRTSMCFNEILTPVTPEPFKEDTLGLQNSANRHLQPPLTALEATQALYSAFVHDPMKLYVFGANVGYSLSPAMHNAALKACGIPHHYRPLSTANIGTLREVISDPQFAGASVGLPFKVEIISLTHSLSRHAKAIGAVNTLIPVRHLSADGGIPDEVSMFNNISQAGPVKALYGENTDWIGIRACLRRGLSPANAVRSTSTGLVIGAGGMARAAVYAMLQLGVKKILIFNRTFANAEKLVLHFENLLARDALPLLSTGPRSHDNTSFHIIRSRDELLPENFKNPTMIVSCIPTHTVDNTPDPEFTVPLHWLDNPTGGIVLELDYKCLTSPLLEQTRREAHRGWVAMDGLDLLPEQGFAQFELFTGRRAPRRLMRREVLRAYPDDQEKSYTAQLQPRLNKIATQIS
What is the function of this protein?
Multi-domain repressor protein that negatively regulates transcription of the quinate utilization pathway genes.  May mediate its repressor activity by binding directly to the qa-1f activator protein (By similarity).
What are the official names of this protein?
Quinate repressor protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the shikimate dehydrogenase family.
Protein: PUS2_ARATH
Sequence: MLSISQLPSFSLTTAKSLRYPSSPSSSLSIFFSFFPKVSNFVRASSGIPNLVACSPTEIIIPRVNNAGLRIEEIVDAAKGKIRLDSWISSRINGVSRARVQSSIRLGLVTVNGRVVDKVSHNVKSGDEVNCTISELQPLKAEAEDIPLDIVYEDKHVLVVNKPAHMVVHPAPGNPTGTLVNGILHHCSLPCVDYSNSEEDDDSDEETFSDDEEMTTSPSSYAASVRPGIVHRLDKGTTGLLVVAKDEHSHAHLAEQFKLHTIERVYVSLTTGVPSPPQGRIEIPIGRDSSNRIRMAAIPGGVRGGRARHAASRYKVIETFAGGGSALVEWRLETGRTHQIRAHAKYMGVPLLGDEVYGGTKSMALSLLQKRVSRSDQEEIIELISRMDRPCLHAIVLGFTHPCTGEIVKFSCPPPSDLAEIVGLLRRSGL
What are the official names of this protein?
RNA pseudouridine synthase 2, chloroplastic, RNA pseudouridylate synthase 2, RNA-uridine isomerase 2.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COAD_RALPJ
Sequence: MVIAVYPGTFDPFTRGHEDLVRRASNIFDELIVGVAQSPNKRPFFALEERIEIAREVLGHYPNVRVEGFSGLLKDFVRKNGARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFLTPSDQYQFISGTFVREIAVLGGDVSKFVFPSVEKWLKEKTGKTEGSGKSE
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBP47_XENTR
Sequence: MRPGEESHLVPKEIENAADEPRVLCIVQDTTSCKNINERITLNLPASTSVKQLYEDVSSKAGYVSGTFSLMWGNGASNMVDMAALDPTPDRTLQEAGFEAGKKNFLHLTDKNGEQPQLASDESGTADSSGLDDSTQEKFIGPLPREESVACTSDYVSQNYSYSSLLSKSDTGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVSSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINQLYQGKLKDYVKCLECGYESWRIDTFLDIPLVIRPFGSNTAFGSMEEALQAFIQPETLDGPNQYFCERCKRKCDARKGLKFLHFPYLLTLQLKRFDFDYTSMHRIKLNDRMTFPDELDMSPFIDVEDEKSPQTDSCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLETNSNIEKLNKSVSEKNSLYELFSVMVHSGSAAGGHYYACIKSFADGQWYSFNDQHVSRITQEDIKKTYGGSTGNRGYYSSAFASSTNAYMLMYRLKNPARNAKFPEAIEFPEHIKLLVQKEQEQEEQEKRQREIERNTCKLKLFCMHPVKQIMMESKLEVHKDKTMKEAVEIAHKLMDLEGVISLDCCRLVKYDEFHDYLERSYEDEEDRTMGYLLGGVKSSYMFDLLLETKRSDQVFQSYKPGEVMVKVYVVDLKTETVAPPVSVRAYLSQTIIEFKQLISKSVDLLPDTMRVVLERCYNDLRLLNVANKTLKAEGFFRSNKVFVESSDSLDYQLVFTDSHLWKLLDRHANTIRLYVSLPEHTPQTARSVGPKGGGDSNLSEDYCSRVKGNVKSVDAILEESTEKLKSLSLQQHQDGGNGDSSKSTEGSDFENIDSPLNEADSGSADNRELENRILPADPENNFQPEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAPIPLANGLDSHSITSSRRSKANDGKKETWDTAEEDSGTDSEYDESGKSRGEAQYMYFKAEPHAGEGCLGEGNKCLLVSVDKRITLAAFKQQLESFVGVSSSQFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRVKIFQLLVNEPEPCKFLLDAVFSKGMTVRQSKEELLPLLRDQCGLDLSIDRFRLRKKTWKNPGTVFLDYHVYENESISSSWEVFLEALDETEKMKSMSQLSLFTKRWRPSELKLDPFKEIVMESNSVDELRDKICDISAIPLENLEFAKGRGTFPCDISVLEIHQDLDWNPKVSTLNAWPLYISDDGAVIFYRDKMEELVELTDEQRNDLAKKESSRLQKTGHRVTYSPRKEKALKIYLDGPSNKDSSQD
What is the function of this protein?
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 47, Deubiquitinating enzyme 47, Ubiquitin thioesterase 47, Ubiquitin-specific-processing protease 47.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP47 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCDD_ACIFV
Sequence: MTDNPWLIMMINMTIVFGVLIVLGILMVLIHAVDPTKKVQGKKKPVVAKPAPSAAASKRQEEEKVAAMAAVLALVQDEDDMIAAALSAAIAEHKRKMEPMNLPHHSF
What is the function of this protein?
Part of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).  Possible membrane anchor for the alpha subunit.
What are the official names of this protein?
Glutaconyl-CoA decarboxylase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the OadG family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: VATB_PYRNV
Sequence: MLTPVVSYSTVKEVKGPLLVIERTRGVAYGEIGEVVGPDGEPRRVQVIEVGTDYAVAQVLGGTLGLPAKGSTVRFYGKTLKLPVSEELIGRILDGKGQPRDHMPLPPPEDFRDVNGEPLNPYSREYPEEPIETGISAIDGLYTLVRGQKLPIFSGTGLPHNLMAAQVVRQSTVRGSEEGFAVVFVGVGIKTEEAIFFMDEFRKTGALRRAVAVLNLASDPVAERILAPRVGLTIAEYLAWQLGYHVLVVITDMTNYCEGLRELSSGRGELPGRRGYPGYMYTDLATIYERAGKARGKKGSVTQFPILTMPHDDITHPIPDLTGYITEGQLVLSRSMWGKGIYPPFDVIMSLSRLAKDAIGEGKTREDHKDVANTLISAYSKALELRNLATLVGERNLGWRERRYLRFADAFEQRFIKQGYYERRSFEETLDIGWDVMSILPEDELTNARPQITQKFYRRHIFESIKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: SYP_SYNR3
Sequence: MRVSALLLVTLRDDPAEAEIPSHKLLLRGGYIRRVASGIYAYLPLMWRVLRKVSAIVRQEMDAAGALETLLPQLQPAELWQRSGRWSGYTAGEGIMFHLQDRQDRELGLGPTHEEVITALAADLLRSYRQLPVNLYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFHASAEDLGRGYAAMDQAYRRIFSRCGLQVVAVQADSGAIGGSASQEFMVTAEAGEDLILSSADGSYAANQERAESLPAEPVPLQSATAAELDTPGQTSIDALVEAQGWHASQLVKVILLVARFEQGRQQPLLVSLRGDQQLNEVTLANWLNQQHGQAWGALLGIEPLEAKHLAAEKVPAFGYLGPDLSDAVLQGSKKLESSFLRLADPTALDLPLFICGANRFNAHRLAANWSEPGMASPQRVELRAALPGDRCCHDPSQQLQARRGIEVGHIFQLGLKYSEALGATFANEQGQDAPLWMGCYGIGVSRLAQAAVEQHHDSAGMVWPVPIAPFEVVIVIASSKEAQQVELAEDLYGQLQQAGVDVLLDDRNERAGVKFKDAELIGIPWRLVVGRGAVNGQVELVERCSGEKQEGPHQDLMAQLLQTLDQQRQGL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF13_YEAST
Sequence: MSRKLKKTNLFNKDVSSLLYAYGDVPQPLQATVQCLDELVSGYLVDVCTNAFHTAQNSQRNKLRLEDFKFALRKDPIKLGRAEELIATNKLITEAKKQFNETDNQNSLKRYREEDEEGDEMEEDEDEQQVTDDDEEAAGRNSAKQSTDSKATKIRKQGPKNLKKTKK
What is the function of this protein?
Functions as a component of the DNA-binding general transcription factor complex TFIID.  Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation.  TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 13, Function unknown 81 protein, TAFII-19, TAFII19, TBP-associated factor 13, TBP-associated factor 19 kDa.
What is the protein family that this protein belongs to?
Belongs to the TAF13 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TVB58_HUMAN
Sequence: MGPRLLFWALLCLLGTGPVEAGVTQSPTHLIKTRGQQATLRCSPISGHTSVYWYQQALGLGLQFLLWYDEGEERNRGNFPPRFSGRQFPNYSSELNVNALELEDSALYLCASSL
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 5-8.
What are the subcellular locations of this protein?
Cell membrane.
Protein: PSPA_MYCTO
Sequence: MANPFVKAWKYLMALFSSKIDEHADPKVQIQQAIEEAQRTHQALTQQAAQVIGNQRQLEMRLNRQLADIEKLQVNVRQALTLADQATAAGDAAKATEYNNAAEAFAAQLVTAEQSVEDLKTLHDQALSAAAQAKKAVERNAMVLQQKIAERTKLLSQLEQAKMQEQVSASLRSMSELAAPGNTPSLDEVRDKIERRYANAIGSAELAESSVQGRMLEVEQAGIQMAGHSRLEQIRASMRGEALPAGGTTATPRPATETSGGAIAEQPYGQ
What is the function of this protein?
Involved in resistance to stress.  Facilitates intracellular growth of M. tuberculosis.  Associates with and regulates lipid droplets (LDs) homeostasis under conditions of stress and may regulate non-replicating persistence (NRP).  Could be involved in preservation of envelope integrity and tolerance to surface stress.
What are the official names of this protein?
PspA protein, 35 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PspA/IM30 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the surface of lipid droplets (LDs).
Protein: RL16_SHEWM
Sequence: MLQPKRMKFRKMFKGRNRGLANGTEVSFGDFGLKAVGRGRLTARQIEAARRAMTRHIKRQGQIWIRVFPDKPITSKPLEVRMGKGKGNVEYWVCQIQPGKVLYEMDGVSEELAREAFALAAAKLPLKTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: FETP_ECO55
Sequence: MSRTIFCTFLQREAEGQDFQLYPGELGKRIYNEISKEAWAQWQHKQTMLINEKKLNMMNAEHRKLLEQEMVNFLFEGKEVHIEGYTPEDKK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: TEG1_EHV1B
Sequence: MDGGGSSSWTHVSKNLIERRAVKGCLLPTPSDVMDAAVMALKDVTENIVGQQLFSVDRTNALSVIHTNEVPESIIATAIARDTSRDYLREYEGAAKCNLAATDLSHDEMWEVVIKRYWRYLRESSGAEVVDRGAVGQATQSVLSVLLLQSTFGKKRLSKNPFKHKGPNVGYKSNLEDLRSAFTKIEKYMYYMRPNDPMTKSEDTELRLHELLAYVTTCYRWLLWFMDLTDAKVLRNIDKGPVITHGPRESRPPDELVRRHLKSGPAISAGTGVALTLSTATADALIVLLRMSVSWTSHSWKSNTHGVTGAIVAAVELVTLIHHHLQYIINTVFAGYVCWLDGGVENSYLNSALRSQGRFDHFVGKLVPIMATLSWANMEKGTVMWFKYALAKSIVCHGSPTQHYLTVLESIASKRTGACPPQGSTFGRNPSGFPGQFCCPPQGPLPAPPNSKTRGTFRRCRPGSLRSSRQLPTSPPSNIVSPRTNPAIEGSTAAKNVQGAETIQVRSSGEFNDCIWYINGAYPHQRSDSSSSDNSTCSSTETQYITLPSTPSPTGDVVYTNPLLGPDEEVDASPQPVDPMSDYSAPKNPDYMRPRSTLVEEVWQLRDSDYTPYMRPSRAGRSRVRVEDQTLEPSSPAGCNPPANSPENDSDDAAVDSPPISPEVVYGTFRPRAKCVYDQYGLTALAALSASRAKARRTRPGPTQPDVCRERDEESAEPRHDGFIRRTMSTTGPPRKHPDQTERVSSL
What is the function of this protein?
Modulates alpha trans-inducing factor-dependent activation of alpha genes.
What are the official names of this protein?
Tegument protein UL46 homolog, Tegument protein VP11/12 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HHV-1 VP11/12 protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cell membrane; Peripheral membrane protein.
Protein: ARNC_PROMH
Sequence: MSTFEKINKVSVVIPVYNEEESLPQLLERTIKSCKQLEQEYELILVDDGSSDNSAKMLEEAANIEDNHVIAIILNRNYGQHSAIMAGFNQADGDLVITLDADLQNPPEEIPRLVATAEEGYDVVGTRRRNRQDSWFRKTASKMINAMITKATGRSMGDYGCMLRAYRRHIIDAMLQCHERSTFIPILANTFARRTIEIEVAHAEREYGDSKYSFLKLINLMYDLLTCLTTAPLRLLSVVGSVIAVAGFLLAVLLIVLRLIFGAIWAADGVFTLFAILFMFIGAQFVAMGLLGEYIGRIYNDVRARPRYFIQKVVGVKKPNKNQEED
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.