PharMolix/UniProtQA huggingface dataset:
Protein: TLR8_HUMAN
Sequence: MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY
What is the function of this protein?
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612).  Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653).  Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses (PubMed:33718825).  Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:33718825).  In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).
What are the official names of this protein?
Toll-like receptor 8.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Endosome membrane; Single-pass type I membrane protein. Note=Endosomal localization confers distinctive proteolytic processing.
Protein: RNH2_RICRO
Sequence: MEVDLLHFEKKYHNCIVAGIDEAGRGPLAGPVVASAVIVDNANIITGIKDSKKLSKKKRELLYEQITSNYAWATAIISHTEIDDINILEATKKACSIAVANLSLEPEIVLVDGNMQFKDERFVSIINGDNLSLSIAAASIIAKVTRDRLMLDLSAEFPQYLWHKNSGYGTKEHIEAINIHGLSPYHRRSFRCC
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYV_CORGL
Sequence: MVCVTDQNNETTSQNRADKLPKSWDPKAVEADLYQGWVDAGYFTADPASDKPGFSIVLPPPNVTGQLHMGHALDHTLMDALARRKRMQGFEVLWLPGMDHAGIATQTKVEEMLKETEGKTRYDYDREEFIAKVWEWKQEYGGKIGEQMRAIGDSVDWSRERFTLDDGLSRAVQTIFKKLFDAGLIYQANRLVNWSPVLETAVSDIEVIYKDVEGELVSIRYGSLNDDEPHVIVATTRVETMLGDVAVAVHPDDERYKDLVGQTLPHPFRDDLSLKVVADDYVDPEFGSGAVKITPAHDPNDYALGLRHNLDMPTIMDKTGRIADTGTQFDGLTREEARIKVREELAAQGRIVKEIRPYVHSVGHSERSGEAIEPRLSLQWFVKVEELAKMSGDAVREGDTTIHPKSLEPRYFDWVDNMHDWTISRQLWWGHRIPIWYGPNDEIICVGPDEQAPEGYVQDPDVLDTWFSSALWPFSTMGWPEKTPELEKFYPTSVLVTAYDILFFWVARMMMFGTFAAKETPELLGEGKDGRPQVPFTDLFLHGLVRDEHGRKMSKSLGNGIDPMDWVENYGADALRFTLARGANPGVDLPVGEDSAQSSRNFATKLFNATKFALMNGAVSEGLPAREELTDADRWIVDLLEQVRLDVDAYLDNYQFAKANEELYHFAWNEFCDWYLEIAKVQIPREGTSAQGENTQKVLGHVLDALLRLLHPAMPFVTEVLWQALTDRTSIVVASWPTAADTNGGVAVDADAARRIGDVEKLVTEVRRFRADQGVKPSQKVPARLDFVACDLQDLEDSVRSLVRIEQPEDDFAASASLEIRLSQATITVELDTSGTVDVAAERKRLEKDLANAQKELETTAKKLGNEAFLSKAPDAVVDKIRGRAQIAQEEVERINKRLEELA
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_DESDA
Sequence: MADKISVCVAGGGSWGTALGHLLARGGHDVSIWLRDDAVARTINRKHENPRYLPGLPLDPRLAATTDPAVLARPLVVLAVPCQQLRPWLAGHACHFQPGVTLVNAAKGIETGSLATCAEITAQELGGLNPRYAVLSGPSFAADVLRDLPTAVVLASYDEALGRYLRGVFSGPAFRCYSSTDVVGVEMGGALKNVMAIAAGTCDGLGLGANSRAALVTRGLAEMSRLGVARGAQAHTFMGLSGLGDLTLTCTDDLSRNRQVGLRLGRGEKLEHITQSLGMVAEGVKTTAAIHEMAQKLQVEAPLTRAVYGILYKEMAPPTVLSDLMARDLREE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_SHIF8
Sequence: MKAKELREKSVEELNTELLNLLREQFNLRMQAASGQLQQSHLLKQVRRDVARVKTLLNEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: MASZ_MARN8
Sequence: MTERVQVGGIQIAKNLYDFVNNEAIPGTGIEADKFWAEFDKIVNELAPRNRELLLKRDEIQEKMDTWNREHKGQKLDMAEYKAFLKDIGYLVDEPADFKISTSNVDPEIATMAGPQLVVPVMNARFALNAANARWGSLYDALYGTDAISEENGAEKGRGYNPVRGAKVIEWARNLLDGSAPLASGSHKDAAKYYIDGGKLAVKLQNGDVTGLKDESGFVGYTGAADAPTGVLLVKNGMHFEIQIDASHPIGKDDGAHVKDVLMESALTTIMDCEDSVAAVDADDKVVAYKNWLGLMKGDLEESFEKGGQMMTRRMNGDRTYTGADGSELTLKGRSLLFVRNVGHLMTNPAILLKDGSEIPEGLMDGLVTSLIAIHDLKGDGKFQNSTKGSVYIVKPKQHGPEEVAFTNEFFGRVEDALGLPRFTLKVGIMDEERRTTVNLKACIHAAKERTVFINTGFLDRTGDEIHTSMELGPFIRKGPMKQAAWINAYEQWNVDIGLEAGLSGVAQIGKGMWAMPDLMAGMLEAKIGHPKAGANTAWVPSPTAATLHATHYHQVNVFDVQKELANRQRASLDDILTVPVMEDPSSLSAEDIQQELDNNAQGILGYVVRWIDQGVGCSKVPDINDVGLMEDRATLRISSQLLTNWLYHGICSEEQIMETMKRMAAVVDKQNAGDAAYRNMAPNFDDSIAFQAAVDLVLKGREQPAGYTEPLLHAYRQKAKAKYGQ
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_TRIL1
Sequence: MGRKKISLIGGGQIGGVLAQLCALRELGDVVMFDIVEGMPQGKMLDIAEASPVDGFDVCLQGTQDYKDIAGSDVVIVTAGLPRKPGMSRDDLIATNSKIMTSVAEGIKQYASNAFVIIISNPLDAMVTLCQKITGMPANRVVGQAGVLDSARFKAFIAWELGVSVKDVSAMTLGGHGDDMVPLVRYAAVNGIPVMELLEQKYGAEKAKEVMEAMVNRTRLAGGEVVALLKTGSAFYSPASSAIAMAESVLKDQKRVLPTCCLLNGEFGVNGYYVGVPAVLGASGVEKILQFKLDATEQAMMDKSVAAVKGLVDSLDSILKG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: MURD_PARMW
Sequence: MAQTVVVGLGRSGQGAARLLQATGHPVSVIDSGQGEQLEKKAEGLRQQGVEVQLQAPLAIDSFRPWLDQLQRVVISPGVPWDHPTLDDLRQRGVAVDGEMAVAWDALKHIPWVGITGTNGKTTVTHLLSHVLCQAGLAAPMGGNMGVSAAEMALNLQQEHTTAPDWLVMELSSYQIEAAKRIRPRIGIWTTLTPDHLERHGTVEAYRAIKRGLLERSDHAIFNADDPDLRQQRQSWTGGTWVSAESAQPDGHPADLWINGKGWVCDRSQPLFPAEALAMPGAHNRQNLLLVTAAARQIGLSPASIVAGLRSFPGVPHRLEPVGRIGNAQVFNDSKATNYDAAAVGLKAMQGPVVVLAGGSTKQGDATGWLEELNRKACAVVLFGAGTEELHGLITGANFTGELTRRTDLTSAVEEAVRSAEALGATSLLLSPACASFDQYRDFEARGDHFKQLIHQVQSGLN
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARB_STRGC
Sequence: MPKRKDIQKIMVIGSGPIVIGQAAEFDYAGTQACLSLKEEGYSVVLVNSNPATIMTDKEIADRVYIEPITLEFVARILRKERPDALLPTLGGQTGLNMAMELSKSGLLEELGVELLGTKLSAIDQAEDRDLFKQLMEELGQPIPESEIVNTVDEALEFAAGIGYPVIVRPAFTLGGTGGGICSNEGELQEIAENGLKISPVTQCLIERSIAGFKEIEYEVMRDGADNALVVCNMENFDPVGIHTGDSIVFAPSQTISDYEYQMLRDASLKIIRALKIEGGCNVQLALDPNSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEIINPVTGSTYAMFEPALDYVVAKIPRFPFDKFEHGERRLGTQMKATGEVMAIGRNIEESLLKACRSLEVGVDHNELPALSQVSDDELMRKIVKVQDDRLFYISEAIRRGYSPDEIAELTKIDVFFLDKLLHIYEIEQELASHIGDSYVLKKAKQNGFADTKIATLWDMTAQQVRRIRQDQKIMPVYKMVDTCAAEFESATPYFYSTYGFENESVKSSKESVLVLGSGPIRIGQGVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDLEQPKGVIVQFGGQTAINLAEPLSKAGVKILGTQVADLDRAEDRDLFEQALKELDIPQPPGQTATNEEEAIEAARKIGFPVLVRPSYVLGGRAMEIVENEADLRSYMRTAVKASPDHPVLVDSYIVGDECEVDAISDGRQVLIPGIMEHIERAGVHSGDSMAAYPPQTLSQKVKDTIADYTKRLALGLNCIGMMNIQFVIKDEQVYVIEVNPRASRTVPFLSKVTDIPMAQVATRLILGETLAELDYEDGLHPESFMVHIKAPVFSFSKLAKVDSLLGPEMKSTGEVMGSDRTLEKALYKAFEASYLHLPNFGNVVFTIADDSKEEALQLAQRFANIGYGIWATKGTASYFENHGLHVRLVEKIGSDDDKDIPAYIRKGKIQAIINTVGTKRTADKHGQIIRSSAIEHGVPLFTALDTADAMLKVLESRSFTTEAI
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: DNAK_VIBPR
Sequence: MGKIIGIDLGTTNSCVAVLDGDKPRVIENAEGERTTASVIAYTDGETLVGQPAKRQAVTNPTNTLFAIKRLIGRRFEDEEVQRDIEIMPYKIVKADNGDAWVEAKGQKMAAPQVSAEVLKKMKKTAEDFLGEEVTGAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKKGGDRTIAVYDLGGGTFDISIIEIDEVEGEKTFEVLATNGDTHLGGEDFDNRLINYLVDEFKKEQGIDLKTDPLAMQRVKEAAEKAKIELSFTSQTDVNLPYVTADATAPKHMNVKVTRAKLESLVEDLVQRSLEPLKVALADADLSVNDITDVILVGGQTRMPMVQAKVAEFFGKEARRDVNPDEAVAMGAAVQGGVLAGDVKDVLLLDVTPLSLGIETMGGVMTKLVEKNTTIPTKANQVFSTAEDNQSAVTIHVLQGERKQAMYNKSLGQFNLEGIQPAPRGMPQIEVTFDLDADGILHVSAKDKQTGKEQKITIQASGGLSDDEIEKMVQEAEANKEADKKFEELATARNQADQMIHGTRKQVEEAGDALPAEDKEKIEAAVSELEDARKGDDKEAIDAKVQALMTASQKLMEIAQQQAQAQAAQGGDEAAQSKDDDVVDAEFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RBGA_BACSH
Sequence: MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMIEDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKEILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQWVKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYPERLKERYALDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLSFEQPTM
What is the function of this protein?
Essential protein that is required for a late step of 50S ribosomal subunit assembly.  Has GTPase activity that is stimulated by interaction with the immature 50S ribosome subunit.  Binds to the 23S rRNA.  Required for the association of ribosomal proteins rplP and rpmA with the large subunit (By similarity).
What are the official names of this protein?
Ribosome biogenesis GTPase A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTC1A_PSESH
Sequence: MNARHFLSMMDYTPDELLGLIRRGVELKDLRIRGELFEPLKNRVLGMIFEKSSTRTRLSFEAGMIQLGGQAIFLSHRDTQLGRGEPIADSAKVMSRMLDAVMIRTYAHSNLTEFAANSRVPVINGLSDDLHPCQLLADMQTFLEHRGSIKGKTVAWIGDGNNMCNSYIEAAIQFDFQLRVACPAGYEPNPEFLALAGERVTIVRDPKAAVAGAHLVSTDVWTSMGQEEETARRMALFAPFQVTRASLDLAEKDVLFMHCLPAHRGEEISVDLLDDSRSVAWDQAENRLHAQKALLEFLVAPSHQRA
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.
What are the official names of this protein?
Ornithine carbamoyltransferase 1, anabolic, OTCase 1, Ornithine carbamoyltransferase 1, phaseolotoxin-sensitive, SOCT.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_BORDL
Sequence: MSTIKSGDIDKGSFLLFKGMPHIVLEREFSKMGRGGSIVRLKLKNLKNKSVIKETLKGSDTVEEIEVLEVNSQYLYKDNESLIFMDLETYDQFSVNLRDVVNLEDKVLFLQEAEVYSLIKWGNEVIDLKLPPKVAFEVIDAEIAVKGDTVTNAMKNVTLHTGLVVKAPLFINIGDKILVNSETKEYAERVKV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3535_HELPS
Sequence: MEKLPKKRVSKTKSQKLINSLTTQKNRAFLKKISASEMLLELEKGAFKKNEAYFISDEEDKNYVLVPDNVISLLAENARKAFEARLRAELERDIITQAPIDFEDVREVSLQLLENLRQKDGNLPNINTLNFVKQIKKEHPNLFFNFDNMFKQPPFNENNFENFDNSDEENF
What are the official names of this protein?
UPF0763 protein HPSH_03535.
What is the protein family that this protein belongs to?
Belongs to the UPF0763 family.
Protein: RS10_NITOC
Sequence: MAKQQIIRIRLKAFDHRLIDQSAREIVDTAKRTGAHVRGPIPLPTRKERFTILISPHVNKDARDQYEIRTHKRLMDIVDPTEKTVDALMKLDLAAGVDVQIKLT
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ATPB_XYLFA
Sequence: MNQGKIVQIIGAIVDVEFPRNNVPKVYNALKIDGTAIILEVQQQLGDGIVRTIALGSTDGLKRNLIATDTGHAITVPVGTGTLGRIMDVLGNPIDEAGPITYTDQWEIHRNAPSYEDQASTTELLETGIKVIDLMCPFAKGGKVGLFGGAGVGKTVNMMELINNIAKAHSGLSVFAGVGERTREGNDFYHEMKDSNVLDKVAMVYGQMNEPPGNRLRVALTGLTMAEYFRDEKDSSGKGKDVLLFIDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTANGSITSIQAVYVPADDLTDPSPATTFGHLDSTVTLSRSIAALGIYPAVDPLDSSSRQMDPLIIGEEHYNTTQRVQQTLQKYKDLKDIIAILGMDELSEDDKLAVSRARKIERFFSQPFHVAEVFTGAPGKYVPLKETIRGFKAIVDGEYDHLPEQAFYMVGNIEEVIEKANKMTA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TBG_RETFI
Sequence: MPREIITLQVGQCGNQIGTEFWGRLIAEHGIGPDGIVKEFATEGTDRKDVFFYQADDQHYIPRALLIDLEPRVINSLQESEFKNLWNPENVYIDSQGGGAGNNWAVGYTHATEKYEHIMDMIDREDNSDSLEGFVLTHSIAGGTGSGFGSHMLEQLTDRYPKKIIQTYSVFPNDSERSSVVVHPYNSVLALKRLILNADAVVVIDNTSLHRIADERLQLDFASFKETNSIISTVMAASTTTLRYPGYMNNDLVGLIASLVPTPRAHFLMTSFTPLVIKGAQRRIQKTSVLDVMRRLLQPKNIMVSCGTKKGVYVSILDIIRGDVDPTDIHKSLQRIREKKIVNFIPWGPASIQVALSKQSPYANVPYRVSGCMMANHSNLGNLFARIIRTYDILRKRNAFLNVYKETPVFSENLDEFEDAKETITNLIEEYKAIQTSDYINWGMKQQQSQISQKESSSLANENGNGANNKPGKSAMAL
What is the function of this protein?
Tubulin is the major constituent of microtubules.  The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
What are the official names of this protein?
Tubulin gamma chain, Gamma-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: ACCA_SODGM
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINLDEEVQRLREKSVELTRKIFSDLGAWQIAQLARHPMRPYTLDYVRHIFTDFDELAGDRAYADDKAIVGGIARLDSRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMADRFNLPLFTFIDTPGAYPGVGAEERGQSEAIAKNLREMSGLRVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPIAAEAMGIIASRLKELELIDSIVPEPLGGAHRDVQAIAASLKAQLLDDLSELDGLNTEELLNRRYHRLMNYGYC
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPSS2_METAR
Sequence: MIQLSNPRINKTFEALFALEDIREVFRQSLPTGLSSAEEQALKGKLAEIRKYLDEIEADGVGNGARQKYTGKIGSLDVRTREEEYINIHPIQAAGRLTPEARKAIIAYGDGYSTCDYCRKPFRLDKITKPGIQDFHGDLARWLNMDQARVVPGARRGFQAVASALVEKGDSVIVSALAHYTEFLAVEQAGGVVKEVPKNEQNLITADATAQKIEDVRRTTGKLPVLIMIDHFDYMFANEHDVYGIAKVAKQYGIPFLYNGAYTVGIAPVDGKKIGADFVVGSGHKSMASVAPSGVLATTDEFAAKVFRTTQMVGDVTNRKFGIKEVENMGCTLMGGTLLSMIASFPAVVKRSQPQNWEDEVRKSNYFLEQFRRVQGSNVLSEWPRKHTLTKVDTTGSYNKVAETHKRRGYFFNDELTAKGIIGEFAGATKTWKLNTYGLSWEKTKYLSEAFLDIARKYDLPIN
What is the function of this protein?
Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
What are the official names of this protein?
O-phospho-L-seryl-tRNA:Cys-tRNA synthase 2, Sep-tRNA:Cys-tRNA synthase 2, SepCysS 2.
What is the protein family that this protein belongs to?
Belongs to the SepCysS family.
Protein: NADK_CAMJD
Sequence: MQNKIDHKNIKKIGLVTRPNVSLDKEILKLQSILSIYKVELVLFKESSEILDLPKYGLDDLFKISDFVISLGGDGTLISLCRKACEYDKAVLGIHAGHLGFLTDFKVDEAENFFQAFFQGEFRIEKPYLLSVFLEDKQGKILEKLAFNDVVISKNNQAPMAHIEVFRKEKKFNEYFGDGLIVATPAGSTAYNLSANGPIVYTLAQAFILTPVCSHSLTQRSIVLPKGFEIEIMAKDCILCIDGQENYKMNDFKSIKVGLSDKNVALIHPKNRDYFQILKEKLHWGN
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO4_STAA2
Sequence: MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGLTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTNKNMTIYDFI
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_PYRAB
Sequence: MDLYERWKRTVEMLEREGIIRSLEVKEAFLKYPRYMFVEDRYKSYAHIDEPLPIPAGQTVSAPHMVAIMLEIAKLKEGMNVLEVGTGSGWNAALISYIVKTDVYSIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKVPEPLVEQLKPGGRLIIPVGSYHLWQELLEVVKKKSGEIKVRNHGGVAFVPLIGEYGWRE
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins (By similarity).
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_RUEPO
Sequence: MSDLNTLTLAQARDALRKGETTSVALTEACLAAIEGAGALNAFVHKTPELALERAKAADERLQGREEAPKMCGLPIGIKDLFCTKGVPSQAASRILEGFKPEYESTVSQQLADAGAVMLGKLNMDEFAMGSSNETSCYGNAVNPWRRGNDDAALTPGGSSGGSAAAVAADLCLAATGTDTGGSIRQPAAFVGITGIKPTYGRCSRWGIVAFASSLDQAGPMTKDVRDAAIMLEAMCGHDPKDSTSAELAVPDFEAMLTGDIRGKVIGIPREYRMDGMPEEIEALWQQGTEMLRAAGAEIRDISLPHTKYALPTYYVIAPAEASSNLARYDGVRYGHRAKLAQGDGITEMYEKTRAEGFGHEVQRRVMVGTYVLSAGFYDAYYNRARKVRSLIKKDFEDVFAAGVDAILTPATPSAAFGLGEMTDADPVQMYLNDVFTVTVNLAGLPGVSVPAGLDKQGLPLGLQLIGRPWEEGDLLNTAYALEQAAGFVAKPSKWW
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: ISPB_SHIFL
Sequence: MNLEKINELTAQDMAGVNAAILEQLNSDVQLINQLGYYIVSGGGKRIRPMIAVLAARAVGYEGNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKATANAAFGNAASVLVGDFIYTRAFQMMTSLGSLKVLEVMSEAVNVIAEGEVLQLMNVNDPDITEENYMRVIYSKTARLFEAAAQCSGILAGCTPEEEKGLQDYGRYLGTAFQLIDDLLDYNADGEQLGKNVGDDLNEGKPTLPLLHAMHHGTPEQAQMIRTAIEQGNGRHLLEPVLEAMNACGSLEWTRQRAEEEADKAIAALQVLPDTPWREALIGLAHIAVQRDR
What is the function of this protein?
Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone.
What are the official names of this protein?
Octaprenyl diphosphate synthase, All-trans-octaprenyl-diphosphate synthase, Octaprenyl pyrophosphate synthase, OPP synthase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: TRPD_MYCBO
Sequence: MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.