PharMolix/UniProtQA huggingface dataset:
Protein: Y4645_ARATH
Sequence: MHARQRNVGNGYRSGSIGMGMSGSRISPERPMRGHGFYGSEHQHRGFNRGYGRGRGRSKSYHNQLPPPLPPPPVQRRSSGGDVFMEAGRLATEYLVSQGVLPQTVLSSKWQNGNFRKQAGEFQSSRSQEEARMDVSAPAAEKRRYIDGYSSAGSRNSLKGRRSHRYDSDFGRSGSWSERSKAFETETGDDSVSGHQEEQPLAEDIASSVQRSASGEFMRKCEGAGDSESVLDKYNLQDEAQSKTGSSSAGKDIVQDCEISKVSEGSSSLSAGSGEMKGRSGGNGGEDENQTAIEDGSIHQRCEDASIDQQCGADESFTKSGIDLATLCKFEKVPTRTRSSLTAKGPKLYLSHNIKDTSHNSGLEEEDQTENRCETRGQSSGKADSTGDENDQVEDFALVQYIENSKCHRSNSFPSSILRDNSEKESGLELPNLHRSHSVGKVGEKRPGEGSDLEEGSKRQRDWVAVSEANERFNMFKTSGNQCDPEEEGKTSSFNKRLIDGAAGKRVSHESLVNNSTYNRTHTGRTGPGYAEEHQLFPASFKMCDLNLGGASDVNDGIKESRQAVDFDLSISSSSKSLEFGTSTRMSNGKEIEVINLDDDQEVVKSSNDPGRKQEAAPYMGIDDVPDYNERLMMVEYLDSFTPINQGTSSVPQNNNTVSLQDREGAIGNDQVPNNTDDDSIFMSLGEIPLTFLQAWDQPPARGYEKPF
What are the official names of this protein?
Uncharacterized protein At4g26450.
Protein: PPIG_RAT
Sequence: MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELVPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSDSSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEADNVDAQPQSTVRPEEIPPIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRFGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKIEKEKKVKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKQLDSKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREESQSRNKEKYRSQDSKSSHRKENSEGEKRMYSKSRDHSSSNNNREKKADIDQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDKSG
What is the function of this protein?
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.  May be implicated in the folding, transport, and assembly of proteins.  May play an important role in the regulation of pre-mRNA splicing.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase G, PPIase G, Peptidyl-prolyl isomerase G, Cyclophilin G, Matrin cyclophilin, Matrin-cyp, Rotamase G.
What are the subcellular locations of this protein?
Nucleus matrix. Nucleus speckle. Note=Colocalizes with splicing factors at nuclear speckles.
Protein: CSPL1_CHLAT
Sequence: MAAVEAAKTPRFILLIIEWVFALVAFAVMGHYLFDDRRSSFEYLTAICILVWLVVMIYMVILCCGRALPPLIEAAIFLLFAILVFIAFLVTAVKCNNSETIVIAGQTISRKVCEGESEPKAAAAFAFLLGLLLAGSSVLGCIAFRRPSAPPLSSFQNPTSSV
What are the official names of this protein?
CASP-like protein 0U1, CaCASPL0U1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VNS2_AHSV9
Sequence: MAEVRKQQQFTRSVCVLDLGQKTYCGKVVRAVDGVYYTIKIGRTVQCGVTPTPIPKSYVLEIRECGRYRIQDGTDVLSLMITESGIEVTQNRWEEWSFEALTPVPMAVAVNVGRGSFDTEIKYVRGSGAVPPYTKNGMDRRAMPSLPGITTLDVGVRDLRLKMRENREAEREKMERALSGGLDMGSCRMYGGGRNDVREITLDEAGPSRTPRKLSVQSNESRSDDVARRHAELVEMERLRIMKNEPVRTESMWCQSDSDDQSDEDHEVGGTEPENYITEEYTRRLNEVKTKYSKELSSLAMRVPKNEGNCGKPIFSKKCKWENVPIYNYDEASGNYRFVSVGSRTHYHCCANDLSYMILPAGGSG
What is the function of this protein?
Single-stranded RNA-binding protein.
What are the official names of this protein?
Non-structural protein NS2.
What is the protein family that this protein belongs to?
Belongs to the orbivirus non-structural protein NS2 family.
Protein: VSR_GVAIS
Sequence: MDDPSFLTGRSTFAKRRRARRMNVCKCGAIMHNNKDCKSSSISSHKLDRLRFVKEGRVALTGETPVYRTWVKWVETEYHIYIVETSDDED
What is the function of this protein?
Suppressor of viral-induced RNA silencing.  The potential mechanism of action is based on sequestering siRNAs.
What are the official names of this protein?
RNA silencing suppressor.
What is the protein family that this protein belongs to?
Belongs to the carlaviruses nucleic acid-binding protein family.
Protein: ISPG_CLAM3
Sequence: MPAVNLGMPKVPEVLAPRRKTRQISVGKVKVGGNAQVSVQSMTTTQTTNINATLQQIAELTATGCDIVRVAVPHQDDADVLHILAKKSQIPIIADIHFQPRYVFTAIDAGVGAVRVNPGNIRKFDDQVGAIAKAAKAAGVSIRIGVNAGSLHPSLLQKYGKATPEALVESAVWEASLFEEHDFHDFKISVKHNDPVIMVKAYRLLAERGDWPLHLGVTEAGPAFQGTIKSATAFGILLSEGIGDTIRVSLSAPPAEEVKVGLQILQSLNLRERKLEIVSCPSCGRAQVDVYSLAEQVTEGLKHVNVPLRVAVMGCVVNGPGEAREAELGVASGNGRGQIFVKGEVIKTVPEAEIVQTLIEEANRLAAEMPAGSIGSPEILV
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: AMPA_PHOPR
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGKERELDERQYKQIIKKTISTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVETTKDSLYTFNQFKSNKPETRRPLRKLVFNVPTRRELSLGERAITHGLAVASGVKASKDLGNMPPNVANPAYLASQARRLADDFDTVTTKIIGEQEMKELGMTSYLAVGQGSKNEAMMSVIEYKGSADPDAKPIVLIGKGLTFDSGGISIKPSAQMDEMKYDMCGAASVFGAMKSLAQLNLPINVVGVIAGCENMPGGNAYRPGDIITTMSGKTVEVLNTDAEGRLVLCDALTYVERFDPDCVVDVATLTGACVVALGHHISGLLGNHNPLAHELINASEQSGDRAWRLPMSDEYQDQISSPFADMANLGSPGAGTITAGCFLSRFTKKYNWAHLDIAGTAWVGGKEKGSTGRPVPLLVQFLLNRAGLENVE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHP2_CAEBR
Sequence: MGKRNLDETMNESAVSEIAEDVAALTTEKDEYQALCELVNPIAQPLANRKLAKKVYKLIKKAAAGEKTLREGIKDVQKELRKNEKGICILAGNVSPIDVYSHIPAICEEKEIPYVYIPSREQLGLAVGHRRPSILIFVKPSADFQELYDEVAETLHHLTVDAA
What is the function of this protein?
Required for ribosome biogenesis.  Part of a complex which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
What are the official names of this protein?
Putative H/ACA ribonucleoprotein complex subunit 2-like protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HIS4_PROM3
Sequence: MEIIPAIDLLDSACVRLHQGDYAKVTRFSEDPVAQALSWQKQGATRLHLVDLDGAKSGEPVNDSCVRAITSALNIPVQLGGGVRTLERAEELLAYGLEQVILGTVAIEQPQLVKQLAQRNPGRIIVGIDAKNGKVATRGWISQSEVNATDLAADFNAAGIAAIISTDIATDGTLEGPNLESLRAMANASSVPLIASGGVGCMADLLSLLALEPYGVSGVIVGRALYDGKVDLKEAIRAIGDGRLQDPPSSKPLMA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_NEIMA
Sequence: MTYEIQASVREAQGTGASRRLRREGQIPGILYGEGQEPVAIAVDHKTVFYALEKESFHTALIKLSLNGETKDVIVRDFQMHPFRREVQHIDFQAVKADQPVRIRVPLHIVNAENSQAVKLQGGRVSLLNTTVEVVALPANIPAFLDLDCAEVVAGDILHLSDIKLPEGVESVSLKRNENLAVATVTGKKR
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: SCM4_YEAST
Sequence: MQVSPAIVKGIAVSSLGLYAGILTSSTVISITTPINVLTQHLKNVLCTLGCWSTVLGGLATGAFGLSYYLAAPGERPNYLLCGLGVAPLSAAYLYLVSLFNHKLAPKCTRDQNDLEKQKDEKLPQHHPEVKDGEAACPFSKMNNAKTLKPESERSVKCHSYMSLHMSIVTGITIFTFGKCILDGFKA
What are the official names of this protein?
Protein SCM4, Suppressor of CDC4 mutation 4.
What is the protein family that this protein belongs to?
Belongs to the ATG33 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RR3_PELHO
Sequence: MGQKINPLGFRLGTTQTHHSIWFEKRKDYSEGLQEDHKIREHIQNYIEKERISSDSDVISRIQIDKSIDVVKVIIYMGFSQLLTEDEPPKTKIKELQVSLKKAIHFIQNRKLNLAVRKMKKPYGDPTILGKYIANQLKNRVSFRKVMKKAVELVEKAYKKGIQVQIAGCIGGKAQEMARVEWLRKGRVPLQTVTAKIDFCSTQVITIRGVLGIKVWIF
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MURA_SYNY3
Sequence: MLQVATPTATEETQTVIEIEGRASLKGEVRISGAKNSALAIMAGTILCSDDCRLSNLPALADIDKMCQILAAIGVNLERDGDRLVVDSSNVGHGPAPYELVSQLRASFFVIGPLLSRLGMTKVPLPGGCAIGTRPVDLHVRGLQAMGADVHIEHGVVNASIKGHSRRLTGAKIYLDYPSVGATETILMAATLAEGETVIDNAAREPEIVDLANFCRSMGAQIRGDGSSRIIINGVEKLHSTDFPIIPDRIEAATFLCAGAITHSEISLFPVVPDHLASAIAKLREIGPEVAIDAPDRVRLIPRDLRGTDIETLPYPGFPTDMQAQFMALLAVSEGNSVVTETVFENRLQHVAELQRMGANIKLKGNAAFIQGVPFLSGAPVMSTDLRASAALVIAGLAAEGKTIVQGLRHLDRGYEDIEGKLRKLGAKLTRIEQPVTL
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSC_PARPJ
Sequence: MSASRGAVIWMTGLSGAGKSTLANALHQRLMEAGHAAIVLDGDVLRRGLNADLGFTPEDRTENLRRIAHVAALFMQQGFVVIAAVISPEHRHRCSAREIVGDGFIEVFVNAPLNVCEARDAKGLYARARRGEIPHFTGISGPFEAPLAPDVVIESDRMPVDESVDRLLAHLAAMGRPGH
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: SSRP_STAA1
Sequence: MAKKKSPGTLAENRKARHDYNIEDTIEAGIVLQGTEIKSIRRGSANLKDSYAQVKNGEMYLNNMHIAPYEEGNRFNHDPLRSRKLLLHKREIFKLGEQTREIGYSIVPLKLYLKHGHCKVLLGVARGKKKYDKRQALKEKAVKRDVARDMKARY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RN19A_PIG
Sequence: MQEQEIGLLSKYNEGLCINTDPNSILMSILDMSLHRQMGSDRDLQSSASSVSLPSVKKAPKKRRISIGSLFRRKKENKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTSISKQIGDFIECPLCLLRHSKDRFPEIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPCPRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVTLSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDINVGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMALAGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSILNSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDDGSAARSHPGGLSGGLPEGKSSATKWSKEATAGKKSKSGKLRKKSNMKINETREDMDAQLLEQQSTNSSEFEAPSLSDSMPSVADSHSSHFSEFSCSDLESMKTSCSHGSTDYHARFATVNILPEVENDRLENSPHQCSISVLTKTASCSEDPQLNHIAEEHSNNGIRPNVDLYFGNALKETNNNHSHQTMELKVAIQTDI
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF19A, Double ring-finger protein, Dorfin, RING finger protein 19A.
What is the protein family that this protein belongs to?
Belongs to the RBR family. RNF19 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: GPDA_ACTP2
Sequence: MSEMYSAPVTVLGAGSYGTALAIALARNGHKTYLWGHQPEKMAVLATERMNNAFLPDIAFPDALEIESDLVQAIAKAKDILIVVPSHVFADVLKQIKPLLSAHHRIMWATKGLERNTGRLLQTVAQEILGNQYPLAVLSGPTFAKELAQGLPTAIALSSTDSQFADEMQQRIHCAKAFRVYLNNDMIGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGLAEISRLGASLGANANTFMGMAGLGDLVLTCTDNQSRNRRFGLMLGQGKSAEEAMAEIGQVVEGFYNTKEAYLLAQTQGVEMPIVEQIYQMLFCGKNAHDVATSLLGRERKGE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSS_PTPV
Sequence: MSNINYYARELPIMSTSPNQLKRVTVDFVPFGKRHNAPVSLYKGMEIPLHNLRQSVIAKNRLITFLNNYDLPKEWGYEQGLVIKASPSFFDVTIARISMLDVKDALKWCEPNIKRALSWPLTYPTFKIFEFSTLDGYQLNWEKKCDFATQICRVGKGLGLDDSLMFTYKTMMRELSVRNIPAEVFTGQAIEKEIAYIQLIRFMTALEHDKRDDCCQSELFKLVELQYEVTSKELLGNRLWLPLTMLNQDI
What are the official names of this protein?
Non-structural protein NS-S.
What is the protein family that this protein belongs to?
Belongs to the phlebovirus NS-S protein family.
Protein: CHED_SYNC1
Sequence: MSDLILGIGEYGVSKTPGSMVKTYALGSCVAVTMYEPNLKIAGMVHVALPESKLNTAKGEQCPGYFADLGVPLLFKEMVRLGCHARGRGLVVKMLGGAAVMAGNDTFNIGKRNILAVKKILWKLGMGPVAEDVGANYSRTVSLHVDTGLVNVSCPGRGQWQI
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: CYB_HEMDE
Sequence: MTNIRKSHPLAKIINESFIDLPTPSNISAWWNFGSLLGICLILQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWIIRYMHANGASLFFICLFMHVGRGMYYGSYTFSETWNIGILLLFSVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIISALAAVHLLFLHETGSNNPSGMSSDLDKIPFHPYYTIKDILGLLLLIMVLMLLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALIMSILILAIIPLLHTSKQRSMMFRPLSQCMFWLLVANLLILTWIGGQPVEHPFITIGQLASMSYFSILLILMPISGIIENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RODZ_SHIF8
Sequence: MNTEATHDQNEALTTGARLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPADLASTFLRGYIRSYARLVHIPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMTFTWLVLFVVIGLSGAWWWQDHKAQQEEITTMADQSSAELSSNSEQGQSVPLNTSTTTDPATTSTPPASVDTTATNTQTPAVTAPAPAVDPQQNAVVSPSQANVDTAATPVPTAATTPDGAAPLPTDQAGVTTPAADPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEQSPAQ
What is the function of this protein?
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
What are the official names of this protein?
Cytoskeleton protein RodZ.
What is the protein family that this protein belongs to?
Belongs to the RodZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Forms helical filaments along the long axis of the cell.
Protein: SYI_BURA4
Sequence: MSNKKADSKPQAKYPVNLLDTPFPMRGDLPKREPQWVKEWEERGIYEKIRAASKGRPKFILHDGPPYANGDIHLGHAVNKILKDIVVKSRNMAGFDAPYVPGWDCHGMPIEIQIEKQFGKSLPAAEVMSKARAYATEQIEKQKVGFKRLGVLGDWANPYKTMNFVNEAEEIRALGKIIEKGYVYRGLKPVNWCFDCGSALAEAEVEYKDRTDPTIDVMFAFAEPEKTAQAFGLPALPRAEGGIVIWTTTPWTIPANQALNLHPEIVYALVDTERGLLIIAEERVAACMADFKLTGRVVATAPGVKLANLRFHHPLASAHPGYKRTAPVYLGDYVTTDTGTGVVHSSPAYGIEDFMSCKAHGMTDSDFINPVMGDGRYIESLPLFGGLSIWDANPKIVDALNVAGSLLRSEKYTHSYMHCWRHKTPIIYRATSQWFAGMDVTPRDDGRTLREAALEGVEATAFYPSWGKQRLFSMIANRPDWTLSRQRQWGVPMAFFVHKETGELHPRTLELLEEVAKRVEQSGIEAWQSLDPRELIGDDANMYEKNRDTLDVWFDSGTTHWHVLRGSHKDQLQFPADLYLEGSDQHRGWFHSSLLTASMIDGRAPYKGLLTHGFTVDGEGRKMSKSLGNGVDPHEVANRLGAEIIRLWIASTDYSGELAISEEILKRVTEGYRRIRNTLRFLLANLSDFDFAQHAVPVDEWLEIDRYAVAFSAQLQTELLGHYEKYEFHPVVAKLQTYCSEDLGGFYLDVLKDRLYTSAADSRARRSAQTALYHLTHGLLRVLAPFLSFTAEEAWKVFQPASDTVFTETYYAYPEVAGSAALIDKWALLRDVRGNVTKALEEARTANRIGSSLQAEVAVHASGARYDALTSLGDDLKFVLITSAATVVKVDDEAQESVDVAASKYQKCERCWHYREDVGAHADHPTLCGRCFSNLFENGEIRSAA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBLN3_HUMAN
Sequence: MLGAKPHWLPGPLHSPGLPLVLVLLALGAGWAQEGSEPVLLEGECLVVCEPGRAAAGGPGGAALGEAPPGRVAFAAVRSHHHEPAGETGNGTSGAIYFDQVLVNEGGGFDRASGSFVAPVRGVYSFRFHVVKVYNRQTVQVSLMLNTWPVISAFANDPDVTREAATSSVLLPLDPGDRVSLRLRRGNLLGGWKYSSFSGFLIFPL
What is the function of this protein?
May be involved in synaptic functions in the CNS.
What are the official names of this protein?
Cerebellin-3.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Secreted. Synapse. Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on an association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity).
Protein: A1KA6_LOXSA
Sequence: WIMGHMVNAIAQIDEFVNLGANSIETDVSFDKNANPEYTYHGIPCDCGRTCTKWEYFNTFLGGLRKATTPGDSKYHEKLVLVVFDLKTGSLYDNQAYDAGTKLAKSLLQNYWNKGNNGGRAYIVLSIPNLDHYKLITGFKETLTKEEHPELMDKVGYDFSGNDDIGDVAKAYKKAGVTGHVWQSDGITNCLLRGLDRVRKAVANRDSSNGYINKVYYWTVDKRASTRDALDAGVDGIMTNYPDVIADVLGESAYTAKFRIATYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LsaSicTox-alphaIB1avi, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DTD_STRPZ
Sequence: MKLVLQRVKEASVSIDGKIAGAINQGLLLLVGVGPDDNAEDLAYAVRKIVNMRIFSDADGKMNQSIQDIKGSILSVSQFTLYADTKKGNRPAFTGAAKPDLARQLYDSFNEQLAEFVPVERGVFGADMQVSLINDGPVTIILDTKCH
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEO1_HUMAN
Sequence: MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD
What is the function of this protein?
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.  PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.  PAF1C is required for transcription of Hox and Wnt target genes.  PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.  PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3).  PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription.  PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors.  In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription.  Involved in polyadenylation of mRNA precursors.  Connects PAF1C to Wnt signaling.
What are the official names of this protein?
RNA polymerase-associated protein LEO1, Replicative senescence down-regulated leo1-like protein.
What is the protein family that this protein belongs to?
Belongs to the LEO1 family.
What are the subcellular locations of this protein?
Nucleus.