PharMolix/UniProtQA huggingface dataset:
Protein: MED16_ARATH
Sequence: MNQQNPEEEVSLVNNSGGGGIIEAPAIVEEKEEEGLQQKQEETIESTDPILVVVEEKLLEKSVDGEKEDDNSSSSNMEIDPVSPATVFCVKLKQPNSNLLHKMSVPELCRNFSAVAWCGKLNAIACASETCARIPSSKANTPFWIPIHILIPERPTECAVFNVVADSPRDSVQFIEWSPTSCPRALLIANFHGRITIWTQPTQGSANLVHDATSWQCEHEWRQDIAVVTKWLTGASPYRWLSSKPSSGTNAKSTFEEKFLSQSSESSARWPNFLCVCSVFSSGSVQIHWSQWPSNQGSTAPKWFSTKKGLLGAGPSGIMAADAIITDSGAMHVAGVPIVNPSTIVVWEVTPGPGNGLQATPKISTGSRVPPSLSSSSWTGFAPLAAYLFSWQEYLISEIKQGKKPSDQDSSDAISLSCSPVSNFSAYVSPEAAAQSAATTTWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPYDPDEGPSITGWRVQRWESSVQPVVLHQIFGNPTSNFGGQVPTQTVWVSRVDMSIPPTKDFKNHQVAAAGPSVDAPKEPDSGDEKANKVVFDPFDLPSDIRTLARIVYSAHGGEIAIAFLRGGVHIFSGPTFSPVENYQINVGSAIAAPAFSPTSCCSASVWHDAAKDCAMLKIIRVLPPALPRNQSKVDQSTWERAIAERFWWSLLVGVDWWDAVGCTQSAAEDGIVSLNSVIAVMDADFHSLPSTQHRQQYGPNLDRIKCRLLEGTNAQEVRAMVLDMQARLLLDMLGKGIESALVNPSALVFEPWRVDGETITGINPEAMAVDPALVSSIQAYVDAVLDLASHFITRLRRYASFCRTLASHAASAGTGSNRNNVTSPTQNASSPATPQVFPDKSLYLAVGQPTTTTTTTATTNSSGSSHVQAWMQGAIAKISSSNDGSNSTASPISGSPTFMPISINTGTFPGTPAVRLIGDCHFLHRLCQLLLFCFLQRSSRFPQRNADVSSQKLQTGATSKLEEVNSAKPTPALNRIEDAQGFRGAQLGTGVKGIDENSARTTKMGSGNAGQGYTYEEVRVLFHILMDLCKRTSGLAHPLPGSQVGSGNIQVRLHYIDGNYTVLPEVVEAALGPHMQNMPRPRGADAAGLLLRELELHPPSEEWHRRNLFGGPGSEPEDMILTDDVSKLSNSLDLPDTNFSGICDGYNRVHSLWPRKRRMSERDAAFGSNTSVGLGAYLGIMGSRRDVVTATWKTGLEGVWYKCIRCLRQTSAFASPGATKQPNPNERETWWTSRWVYCCPMCGGTWVRVV
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Involved in the regulation of the circadian clock, in the control of flowering time, in freezing- and osmotic-stress tolerance and in both salicylic acid- and jasmonate-mediated defense gene expression.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 16, Protein SENSITIVE TO FREEZING 6.
What is the protein family that this protein belongs to?
Belongs to the plant Mediator complex subunit 16 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GHDC_MOUSE
Sequence: MLLLWLLLLLLLLVPLLAILWQQRSRGARPCWLISLQHRVAWGMLGWAAAWQQWRLDRSTLNVGQSQQQALMWCLKKAQGSCCLPREDTDMRTFRNHLPLTQTSHTQEQESEETLPSPASPQYHGDASLQATLLGLITLNKAYPEALAPGSTACVTPTSPWPCSVPWLGHALGRVSPDGAKDPRTLLLEALISPGLRVLEARTAVELLDVFVGLEADGEELAEAIAAGILGTLLPKRAAELKEALEQGPRGLARRLWPKLQVVVTLDSGGQAEAVAALRVLWCQGLAFFSPAYAASGGVVALNLWPERPQGSYLLPPGVPFIELLPIKEGTQEEAASTLLLTDAQREKEYELVLTNHTSLTRCRLGDVVQVVGTYNQCPVVRFTCRLGQTLNVRGEVTDETVFSVALAQAVGQWPGAKLLDHVCVESRVLDSCEGSAPHYEVFVELRGLRNLSEENRDKLDNCLQEASAQYKSLRFRGSVGPAKVHLVRPGSFRVLREALAAFSSSSCRPPEMPRVIRLRHLAQLLQKRVIS
What are the official names of this protein?
GH3 domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the GH3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Nucleus envelope.
Protein: MUTS_SHESM
Sequence: MNPIDTDDLEKHTPMMRQYLTMKAEHHDMLLFYRMGDFYELFYDDAKRASELLGISLTARGKSGGDPIPMAGIPYHAVEGYLAKLVQIGQSVAICEQIGDPATSKGPVERKVVRIVTPGTLTDEALLQERQDNLLAAVYQGKVGFGYATLDVSSGRFVIAELETKESLEAELQRTNPVEILYSEDFGAMELLHHFKGKRRRPEWEFDYDTSIKLLLAQFGTKDLHGFGITDARLSLQAAGCLMQYVKDTQRTALPHINAITRFNQTDTIVLDAATRRNLELTQNLSGGRDNTLAAVLDNTATAMGSRMLQRWIHQPLRDHAQIFARQTAVNELLETTAHESLHEQLKALGDIERIMARLALRTARPRDFARLRQALNLLPKLQQSLAQLSAPHTVKLGQLLGEFPEEQQLLERAIVDNPPMLIRDGGVIREGYNAELDEWRGLSEGATDYLVQLEAREKERTGIATLKVGYNRVHGYYIEVSRLQSQQVPLNYQRRQTLKNMERYITPELKEYEEKVLSSQGKALALEKQLWDELFDLILPKLHELQAFARAAAELDVLSNFAERAETLGYTCPELSSEIGVKIEAGRHPVVERVSQTPFIANPVTLYNQRRMLIVTGPNMGGKSTYMRQVALITLMAHIGCFVPADRAIIGPIDRIFTRIGASDDLASGRSTFMVEMTETANILHNATAQSLVLMDEIGRGTSTYDGLSLAWSAAEYLAQQVGAMTLFATHYFELTQLPELMAGVYNVHLDAIEHEDTIAFMHAVQEGAASKSYGLQVAALAGVPARVIKAAKHKLHQLESRDHQVEGVNVNGTRAPIQTLLALPEPVENPAVSKLKAINPDNLTPKQALDLLYELKRLS
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: TEX10_DANRE
Sequence: MSKKRKRQDDFQKTKLKVGKKKPKADNATNVNFRSKSIHLPEQLKHGESGPTTHRHLDIKDLLSQLHHFNSNVKQGALVGLRELLSANPTMVELHASVVLSEVAALFTDKDGSVRAAAVRLLRFVAQCIPSERVAPFFPLLSAHLTCAMTHISEAIQEEALRVLDVLLEHYPGLLSQRHTVLLGNFLELISQRRKSGTGQDKSGKGSYALTVTTNRSVTAQQWRLTVLLRLSNFLQAVVEERPLEEGVSSRIGLGMWAVEKGLVTPVDVTWEEHVNGQGKIQLFENSGAGPTSHSAYRLRPDSKSGAGMDKELCSAETVQGFAATLVPLLLEIWVEAAGGGRVQTDSGHLLSAESMALMFQILSILQLLRRMTPQRDQQDVLDAWFRNSYLTDFKQHFMKNFPYGLLEVARHKKKADGKRIKQPVAAGVVAGSTVEPLAVNVTLCQVMVTLSLRGQDHVAAEDADWLGPIRVFIRETLSNGSKLSSKHLAALLEVVWRMIVTQRSRVVTDELLQAVYVQYQQRNLSVNVRSLLLRFFSQLYIQEHQNHPHIARSRILARWLASLPVQLVQLGSRNPQLSAQLLETVQPAAARGNKDLLQSLQKNACSLYDPQEGCVVVLPVESQKRLVQILHFLPEFPAELLACLSEVCNTGRVSASLATTLIRTVHLRSPLSGCSSASQDVPLKDVDYLSFFFTTLTGFSSDMLRALQDKDEDDLLAASTLSPLSVYTTSLDQFLHHWDVVEVVCHCLDTLGSRAQCFDVIQNAIINNLAGLVVVPDCVCVALLRCVPRLLDVNFLPSDTLLHFLSDCCLSMLSLLLQLEQSARKRDAVWEACFAALSSVPRLLRLVLQSFRVLDLCEDELPVLAQILSLLLQHTQLRNHMMANASFLQHIIQDLTHYYGGESREQWLIDLLYCYSVTLSTHRANMGIRDIY
What is the function of this protein?
Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit.
What are the official names of this protein?
Testis-expressed protein 10 homolog.
What is the protein family that this protein belongs to?
Belongs to the IPI1/TEX10 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus.
Protein: DTD_CORK4
Sequence: MKAVVTRVRSASVVVDDSVVGSIPDSDVGGLLVLIGVATGDTSATARAMAEKLARLRIFEGSTADGRPTEVSALDVDAPMLVVSQFTLMGDTSHGRRPSWSAAAKPAEAEPIFNACVEELRDRGLSVDTGVFGAYMAVESVNDGPFTVLVDIPSGDRS
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_CHRSD
Sequence: MANKDAALKALIEPVVTAMGFELWGVDYLSQGKHSRLVIYIESADGVTVDDCAAVSRQVSGVLDVEDPISGEYRLEVSSPGMDRPLFTLEQFASFKGSHVKVKLSTPFEGRRKFQGQLAGVEGDEILLHLDGQEYCFPIESIEQARVVPQFDN
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_GEOMG
Sequence: MKTKFIFVTGGVVSSIGKGLASASLGALLEARGLRVSMQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYTSARLSKRSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDEIKHKILENAKGADVAIVEVGGTVGDIESLPFLEAIRQFKADRGAGNVLYLHVTLVPYIKTAGELKTKPTQHSVKELREIGIQPDILICRCEKDLPHDMKAKIALFCNVEEKGVITSADAEHIYAVPLALHKQGLDDQVVDKLNIWTKAPDLAPWESVVEKLRNPLKGEVHIAIVGKYVNLTESYKSLAEALTHGGIANDCRVYLRYLDSEKLESEGLGGLLDDVDAILVPGGFGERGTEGKIKAIEYARTRKVPFFGICLGMQMAVVEYARNVCGLDNAFSSEFRPDCANPVIHLMEEQKGVERKGGTMRLGAYPCSLSKGTFAHRAYGSLDVSERHRHRYEFNNAFREILVSKGLVISGIYKEGDLVEIVEVADHPWFLGCQFHPEFKSKPLNPHPLFRTFIAAALEHRGKRSQA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PDXH_METPP
Sequence: MRPDIADLRKSYEQGELDEAHSAADPLQQFEQWLDQALKAKLPEPNAMTLATVGADGRPSTRVVLIKGCDARGIVWYTNYESRKGRELAAHPFAALQFHWVDLERVVRIEGRVEKVSDTESDAYYRSRPLDSRLGAWASPQSQVIASRAVLVANAAKVGAQFLLNPPRPPHWGGFRLRPDRWEFWQGRKSRLHDRLRYTQQPTGGWLRERLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: YBEY_PASMU
Sequence: MKQVIIDLQLVCENTDNLPSEAQIQAWANRAIQPEFSDVEMTVRIVDEAESHDLNLTYRGKDKPTNVLSFPFECPDEVELSLLGDLVICRQVVEKEAEEQGKPLMAHWAHMVVHGCLHLLGYDHIEDAEAEEMEGLETEIMQSLGFDDPYLSEKEMHG
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_FUSNN
Sequence: MNKGTITQIISAVVDIAFKDELPAIYNALKVKLEDKELVLEVEQHLGNNVVRTVAMDSTDGLKRGMEVIDTGKPITIPVGKAVLGRILNVLGEPVDNQGPLNAETFLPIHREAPEFDDLETETEIFETGIKVIDLLAPYIKGGKIGLFGGAGVGKTVLIMELINNIAKGHGGISVFAGVGERTREGRDLYGEMTESGVITKTALVYGQMNEPPGARLRVALTGLTVAENFRDKDGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPNLATEMGALQERITSTKSGSITSVQAVYVPADDLTDPAPATTFSHLDATTVLSRNIASLGIYPAVDPLDSTSKALSEDVVGKEHYEVARKVQEVLQRYKELQDIIAILGMDELSDEDKLTVSRARKIERFFSQPFSVAEQFTGMEGKYVPVKETIRGFREILEGKHDDIPEQAFLYVGTIEEAVAKSKDLAK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MAZF_STAAE
Sequence: MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRTLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  A sequence-specific endoribonuclease, it cuts between the first and second nucleotides of 5'-UACAU-3' (PubMed:19251861, PubMed:23994560).  Cleaves the artificial ssDNA-RNA substrate 5'-AAGTCrUrACATCAG-3' between rU and rA in vitro (PubMed:23994560).  Originally found to be a ribosome-independent, with a consensus sequence of 5'-[ACG]UU[ACG]-3' in single-stranded RNA (PubMed:17933891, PubMed:19168622).  Its overexpression inhibits protein synthesis and induces bacterial stasis, it is neutralized by coexpression with cognate antitoxin MazE (PubMed:17933891, PubMed:19168622, PubMed:19251861).  Not all mRNAs are equally susceptible in vivo (gyrB, recA and sarA for example are not degraded), while no degradation of rRNA has been seen (PubMed:19168622).
What are the official names of this protein?
Endoribonuclease MazF, MazFSa, Toxin MazF, mRNA interferase MazF.
What is the protein family that this protein belongs to?
Belongs to the PemK/MazF family.
Protein: Y1595_GLUDA
Sequence: MTDTPPFWQVRSLDEMTTEEWESLCDGCGRCCLHKLREDVTDQVLYTDVACRLLDLESCRCSDYAQRRRKVPDCVQLTPAALADIDWLPPSCAYRLLAEGQTLAWWHPLVSGSPDTVHEAGISVRGRAVSERRAGPLEHHIADWPGTMPRPRRPRIRRPA
What are the official names of this protein?
UPF0260 protein GDI1595/Gdia_1801.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: GPMA_YERE8
Sequence: MAVTKLVLVRHGESQWNNENRFTGWYDVDLSEKGRTEAKAAGKLLKDEGFTFDFAYTSVLKRAIHTLWSILDELDQAWLPTEKTWKLNERHYGALQGLDKSETAAKYGDEQVKLWRRGFAITPPALDKSDERFPGHDPRYAKLTDAELPTTESLALTIDRVIPYWEEVIKPRIASGERVIIAAHGNSLRALVKYLDNLNEEEILELNIPTGVPLVYEFDENFKPIKHYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: RT106_PHANO
Sequence: MVFTSMNTQVRVPQPPPVPAAVVNPTVVTPAGPHPEEIDEAFASSHELRKRTSLFRDISTFILGQASQPSAEPAAKKRKLEEKTTSQSAPAAPGGSLVSSATKAWRTYPGVSFSIPQRKKFTLELLDKKDGGIRAIGASGNVEFSIAWKDVDQVFCLPIPEKAKKQHNFVVIPVHGDGINPLPEHLQGAAPEPIIWTFEEATGKNIVEGEDPGPGPMAEAIHHCLIQAGTGKQVIFPDAEEFASATPESHRKGDKAYHVKAHRGSKEGYLFFTSVGILYGYKKPLAYFDFASVNSIAYAAVLRNTFNLVITTQTQEIEFGMLDQADYAGINDYVQKHGLQDASLAAARRAKKLNVNKPKDKSNGTAPPDADDAEEEEGELQKAERELQDQEDEEEEDYDPGSEGESEGSGSDSEDEDGGGGYDEGDGDEVEADDDEMEE
What is the function of this protein?
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing.  Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA.  Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
What are the official names of this protein?
Histone chaperone RTT106.
What is the protein family that this protein belongs to?
Belongs to the RTT106 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: YNFB_ECOK1
Sequence: MKITLSKRIGLLAFLLPCALALSTTVHAETNKLVIESGDSAQSRQRAAMEKEQWNDTRNLRQKVNKRTEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVIIP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: SMG_COXBU
Sequence: MKDESVLNVLMYLFKNHMQENCTLDLGEKKLLVQLEELGFHRTVIDQALSWLNNLSYSGREPMQLPQKNSFRVFSDYECDLLDTECRRFLITLEQQAILNPHTRELVINQALELSCEGIDVSLLKWVTLMVLFNQSSEKEALASMELLVLDDTVGGIH
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: YIDG_ECO57
Sequence: MPDSRKARRIADPGLQPERTSLAWFRTMLGYGALMALAIKHNWHQAGMLFWISIGILAIVALILWHYTRNRNLMDVTNSDFSQFHVVRDKFLISLAVLSLAILFAVTHIHQLIVFIERVA
What are the official names of this protein?
Inner membrane protein YidG.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FDFT_RAT
Sequence: MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
What is the function of this protein?
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene (PubMed:9575210).  Proceeds in two distinct steps.  In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate.  In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene.  It is the first committed enzyme of the sterol biosynthesis pathway (By similarity).
What are the official names of this protein?
Squalene synthase, SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TCAIM_MOUSE
Sequence: MFCHLRPLRRFGLRKVLPHWLHYSRALSGAEAINALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPTQLTFYIREKTAQNSSEGQEPISTTGFRAVRFTLHSSDLLSTVLYILNSCSLPVEHVQSLNTNVHSQPLKEATGMPDRPIKWHRSYYSFTGFKDPDEDLTHVSRVETTLTSWLGSNGKGAVKKLRNSLPLRKELDRLKNELSELLQLSDIRWQRGWGVAHRCSQLHSLSRLAQQNPGPLQNVKGCTVVFTDRSGMSALGHVMLGTMDVHHHWTRLFESLPSYFDLQRRMSALEAQISNLLGGIQVVYIEELQPALTLDQYYSLLHTFYNQLLRSRVPPHPHPQSLSGLQMILSSDRYAPSLHELGHFDIPALSDPASLQSFMRTKAQQARENMTRREKLKVMENELIQASTKQFSLEKLYKEPSISSRQMVDCCKRLLEQSLPYLHGMHLCVSHFYSVMQDGDLCIPWNWKKGEAMK
What is the function of this protein?
May regulate T-cell apoptosis.
What are the official names of this protein?
T-cell activation inhibitor, mitochondrial, Tolerance associated gene-1 protein, TOAG-1.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YPFA_BACSU
Sequence: MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTGRTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQYVRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEHTRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME
What are the official names of this protein?
Uncharacterized protein YpfA.
Protein: MALK_ECOUT
Sequence: MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV
What is the function of this protein?
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Maltose/maltodextrin import ATP-binding protein MalK.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CWP10_TOBAC
Sequence: QYVKDPDKQVVARIFLDLQLVQR
What are the official names of this protein?
48 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: CHPEP_HELPY
Sequence: MKMILFNQNPMITKLLESVSKKLELPIENFNHYQELSARLKENQEWLLIADDECLEKLDQVDWLELKETISQNKNSVCMYKKGNEAQPFLEGFEVKIKKPFLPTEMLKVLQKKLGSNASELEPSQNLDPTQEVLETNWDELENLGDLEALVQEEPNNEEQLLPTLNDQEEKEEVKEEEKEEVKEEEKEEVKEEEKEEVKETPQEEKKPKDDETQEGETLKDKEVSKELEAPQELEIPKEETQEQDPIKEETQENKEEKQEKTQDSPSAQELEAMQELVKEIQENSNGQENKEKTQESAEIPQDKEIQEVVTEKTQAQELEVPKEKTQESAEALQETQAHELEKQEIAETPQDVEIPQSQDKEVQELEIPKEETQENTETPQDVETPQEKETQEDHYESIEDIPEPVMAKAMGEELPFLNEAVAKIPNNENDTETPKESVTETSKNENNTETPQEKEESDKTSSPLELRLNLQDLLKSLNQESLKSLLENKTLSIKITLEDKKPNA
What is the function of this protein?
Plays an essential role in chemotaxis.  Regulates flagellar rotation through the formation of a complex with chemotaxis protein CheZ (PubMed:21791582, PubMed:26061894).  Plays a major role in colonization of the stomach (PubMed:21791582).
What are the official names of this protein?
Chemotaxis regulatory protein ChePep.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the cell poles.
Protein: MTNK_BACC3
Sequence: MGYYSLTEVTAVQYAKEHGYFEKKANVVCHEIGDGNLNYVFKLDDGEKSIIIKQALPYAKVVGESWPLSIKRATIESKALQIFAKYVPEYVPVVYSHDEELAVTVIEDLSRLTITRKGLIDGEEYPLLSQHIGRFLANVLFYTSDFGLQSEEKRVLEGTFVNPDLCKITEDLVFTDPFGHYDTNDYEPELQLTIDELWSDKTLKLKVAQYKYKFLTRKEALIHGDLHTGSIFSSPSETKVIDPEFATYGPFGFDIGQFIANLLLNALSREEEQRGVLFFHIEKTWSYFVETFTKLWIGEGVEAYTKEKQWLPIILQNIFTDTVGFAGCELIRRTIGLAHVADLDEITNKETRIQAKKQALSLGKELIKYESKNADIQLFRTLFQQTVSGGIKA
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
What are the official names of this protein?
Methylthioribose kinase, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: SFRP1_RAT
Sequence: VRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHQLDNLSHNFLIMGRKVKSQYLLTAIHKWDKKNKE
What is the function of this protein?
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.  They have a role in regulating cell growth and differentiation in specific cell types.  SFRP1 decreases intracellular beta-catenin levels (By similarity).  Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response.  In vascular cell cycle, delays the G1 phase and entry into the S phase.  In kidney development, inhibits tubule formation and bud growth in metanephroi.  Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
What are the official names of this protein?
Secreted frizzled-related protein 1, sFRP-1.
What is the protein family that this protein belongs to?
Belongs to the secreted frizzled-related protein (sFRP) family.
What are the subcellular locations of this protein?
Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding (By similarity).
Protein: KADA_SULIK
Sequence: MKIGIVTGIPGVGKTTVLSFADKILTEKGIPHKIANYGDYMLNTALKEGYVNSRDEIRKLQIEKQRELQALAARRIVEDLSLLGDEGIGLIDTHAVIRTPAGYLPGLPRHVIEVLSPKVIFLLEADPRIILERQKRDNSRARADYSDTTVINEVIQFARYSAMASAVLVGASVKVVINQEGDPSIAASDIINSLM
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase.
What is the protein family that this protein belongs to?
Belongs to the archaeal adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAG_YERPN
Sequence: MIEQPRICVQVHSIYVETQSIPEEERFVFAYTVTVRNLGRSNVQLLGRYWLITNSNGRQTEVQGEGVIGEQPLILPGNEFQYTSGAVLETPLGTMEGHYEMIDHLGQAFRTVIPVFRLAIPALIH
What are the official names of this protein?
Protein ApaG.
Protein: COAA_BACSU
Sequence: MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEFLNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPRIFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMAASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE7_HPV54
Sequence: MHGNVATIEDIVLDLKPEPFDLYCREQLEDSDAEDETAVTQPDKQAFKVLSQCGGVCCKTVRLCVYSTHTGIRVLQELLHQDALQIVCPTCASRL
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.