PharMolix/UniProtQA huggingface dataset:
Protein: STX4_HUMAN
Sequence: MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG
What is the function of this protein?
Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity).  Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity).  In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).  Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity).
What are the official names of this protein?
Syntaxin-4, Renal carcinoma antigen NY-REN-31.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type IV membrane protein. Cell projection, neuron projection. Note=Localizes to neurite tips in neuronal cells.
Protein: NQR1_ORYSJ
Sequence: MEAAAARPVIRVAAICGSLRKASYNGGLLRAAAGVCEESIPGLRVDHVDISGLPLLNTDLETADGGFPPAVEAFRDKVRQADCFLFGSPEYNYSIATPLKNALDWASRGQNCWADKPAAIVSAGGGFGGGRSQYHLRQVGVFLDLHFINKPELAVKAFEQPPKFDSDGNLIDAQIRERIKQVLLSLQAFTLRLQKKD
What is the function of this protein?
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways.
What are the official names of this protein?
Probable NADPH:quinone oxidoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the SsuE family.
Protein: EIF3H_DROVI
Sequence: MANRGARHARTEDSDNTINYVQCDGLAVMKMVKHCHEESSNMDLAQGALLGLVVDKCLEITNCFPFPKSGDETMDEEMYQLTVMRRLRRVNVDHLHVGWYQSSDVGNSLSLALLESQYHYQTSIEESVVVVYDTQKSSRGFLCLKAYRLTPQAIQMYKDGDFTPEAFRTLKVGYESLFAEIPIVIKNSPLTNIMMSELNELLPEDKGHNFLDLGTASVLENHMRSLIERVDELYQEAVRYNKYQQVVFKQDTEKHRALAKLAAENAVRTSKGEPTVPEEEVIKQFRPMPVPARLTATITSGQINTHAQHIAQFCSQSLAKLFITESLQNAKETKEIK
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit H, eIF3h, Eukaryotic translation initiation factor 3 subunit 3.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITA6_HUMAN
Sequence: MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWITKWNENESYS
What is the function of this protein?
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity).  Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity).  Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity).  ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778).  ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).  ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).
What are the official names of this protein?
Integrin alpha-6, CD49 antigen-like family member F, VLA-6.
What is the protein family that this protein belongs to?
Belongs to the integrin alpha chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor.
Protein: AROQ_STUS1
Sequence: MATLLVLHGPNLNLLGTREPGVYGAVTLAQINQDLEQRARAAGHHLLHLQSNAEYELIERIHAARSEGVDFILINPAAFTHTSVALRDALLAVSIPFIEVHLSNVHKREPFRHHSYFSDVAVGVICGLGASGYRLALEAALEQLAAS
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: TRHO_BORPA
Sequence: MTAVVNIAAYKFVSIANPADLREPMLEQAGQRQLKGTVLLAPEGINLFLAGAADAIEGFLRWLRADARFADLQAKYSESARMPFRKLLVKVKREIIRMDHPAIRPEAGRAPAVDAATLRRWLAQGRELVMLDTRNAFEVEVGTFRGALDWRIERFTQFPQAVRDNQAALAGKTVVSFCMGGIRCEKAAIYMAEAGIEHVYQLEGGILKYFEETDGAGFDGACFVFDERVALDAALAPQA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: TEG7_HHV8P
Sequence: MSSPWYTWTCCGINLFGRGNHAYKRLGDPLEGCPERWRQEIDLGLPPGVCLGDVVQSNLGTTALHQTYLLAVQSNKITDYLKRFDVAKIPAGCQETVKTQVKKLQSIQNVVWNTMLALAVGEITVDDSALQSLLNKRAGECVSLMEMEKLATAMASDDSVIWASEISHSLSEPTSVLPLTPAVTRQPEATLPKPPTEDPSVSAMHSSIPPRPSSTLEETTESAIGST
What is the function of this protein?
Plays several roles during the time course of infection, including egress of virus particles from the perinuclear space and secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes.
What are the official names of this protein?
Tegument protein ORF55.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL51 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host Golgi apparatus.
Protein: HCHA_STAAN
Sequence: MSQDVNELSKQPTPDKAEDNAFFPSPYSLSQYTAPKTDFDGVEHKGAYKDGKWKVLMIAAEERYVLLENGKMFSTGNHPVEMLLPLHHLMEAGFDVDVATLSGYPVKLELWAMPTEDEAVISTYNKLKEKLKQPKKLADVIKNELGPDSDYLSVFIPGGHAAVVGISESEDVQQTLDWALDNDRFIVTLCHGPAALLSAGLNREKSPLEGYSVCVFPDSLDEGANIEIGYLPGRLKWLVADLLTKQGLKVVNDDMTGRTLKDRKLLTGDSPLASNELGKLAVNEMLNAIQNK
What is the function of this protein?
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals.  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals.  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE).  Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA.  Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair.  Plays an important role in protecting cells from carbonyl stress.
What are the official names of this protein?
Protein/nucleic acid deglycase HchA, Maillard deglycase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family. HchA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_MYCLB
Sequence: MMVLEQSETSRLGPVFDSCRADNRAALIGYLPTGYPDVPTSVDAMIELVESGCDIIEVGVPYSDPGMDGPTIARATEVALRGGVRVRDTLAAVEAISQAGGRAVVMTYWNPVLRYGVCAFARDLESAGGHGLVTPDLIPDEARQWIAASEKHRLDRIFLVAPSSTPHRLVTTVGASRGFVYAVSVMGVTGARDAVSQVVPELVARVKAVSDIAVGVGLGVRSREQAAQIGGYADGVIVGSALVSALGDGLPRLRALAEELAAGVRQRTFM
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RL34_BREBN
Sequence: MKPSFNPNNRKRKKDHGFRKRMSTKNGRKILAARRQRGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: KDSB_HELPG
Sequence: MIIIPARLKSSRFENKVLEDIFGLPMVVRCAKNANLVDECVVACDDESIMQTCQKFHIKAVLTSKHHNSGTERCLEAVQILGLKNDERVLNLQGDEPFLEKEVILALLEATKNAPFMATCAKVIDEEQAKSPNLVKVVLDSQNNALYFSRSLIPFLRDFDAKRQTPLLGHIGIYGFHNKEILEELCALKPCVLEEIEKLEQLRALYYQKKILVKIVQSQSVGIDTQEDLQNALKIFSPDLLER
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WHIA_NATTJ
Sequence: MSFAKSCKNELSRIEINRECCERAELAAFIHMNGSLTIKGDVTLHLTTENPAIARRIFRVFKSRFKKEMQILMRKKMRLQKGNSYSLILTGKNTVSLVLSNLEITKGSFDLNTGITPELVANRCCKRAYLRGAFMARGSIANPDASYHMEMTADYEEYLDDLIKVMQYFELSPGKLARKKEYVSYLKDSEQICEFLNIIGAHKTLLDYENVRVMKGMRNKINRLVNCETANLQKTVVASLRHIKNIQTIDENLGLTQLPKSLQEVAIKRVEYPEANLKELGELLEPPVGKSGVNHRLRKLEKIAEQLHQTGYYDENNGYLQ
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: ACPS_SHEON
Sequence: MAIVGLGTDIVEIERISAHVARSGDKLAKRVLTEAEFEIYQQHSQPSRYLAKRFAAKEAAAKALGTGIGRGVSFQHIHIGNTPDGAPTIDFTEGAQQRLTLLNGVVGHISIADEKSYAIATVILESR
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGAT2_DICDI
Sequence: MVRFVPWNVPLYRRLETMAVAIYAMVLPVCLIMAFNLIVIPLFWGIAIPYLVWMFYFDTKHESGGRRVSLVRNSILWRYFRDYFPISLIINSNYDPKKNYIFAYHPHGIISIGAFCNFATNANNIDEKLPGLKVHLLTLESNFKIPFLRDVLMSFGMSSVSKKSCENILNSGAGESICLVVGGAEESLDARPGLNEITLKKRKGFIKLALVNGASLVPVYSFGENDIYDQVPNPRGSLVRKIQTKIKDLTGIAPPLFMGRGIFNYDFGLLPVRHKIVTVVGEPIDIPKIKSPTDQVIEHYHQIYVEALQNLFDKHKNSCADKETGNLKIN
What is the function of this protein?
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.  Required for storage lipid synthesis (By similarity).
What are the official names of this protein?
Diacylglycerol O-acyltransferase 2, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, Diglyceride acyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GCSPB_STAAR
Sequence: MTSKSSPLIFERSREGRYAYSLPISDIKTNSVESLLDDKFIRKNKAEFPEVAELDLVRHYTELSNKNFGVDNGFYPLGSCTMKYNPKINEKVARIPGFSESHPLQDEDQVQGSLEIIYSLQEELKEITGMDEVTLQPAAGAHGEWTALMIFKAYHENNGEGHRDEVIVPDSAHGTNPASASFAGFKSVTVKSNERGEVDIDDLKRVVNENTAAIMLTNPNTLGIFEKNIMEIREIVHNAGGLLYYDGANLNAIMDKVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVVKELASYLPKPMVIKDGDKFKYDNDIKNSIGRVKPFYGNFGIYLRAYTYIRTMGATGLKEVSEAAVLNANYIKARLSEHFEIPYKQYCKHEFVLSGVRQKEFGVRTLDMAKRLLDFGVHPPTIYFPLNVEEGMMIEPTETESKETLDYFIDTLISIAEEAKNDPDKVLEAPYTTVIDRLDEATAARKPILKFENLKQEK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: RS12_STRFL
Sequence: MPTIQQLVRKGRQDKVEKNKTPALEGSPQRRGVCTRVFTTTPKKPNSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: CAH1_MONDO
Sequence: MANLNWSYEGENGPEHWSKLYPIANGDNQSPIDIKTKEVKHDASLKPISVSYNPATAKEIVNVSHNFQVNFEDKDNQSVLKGGPFTGSFRLRQFHFHWGTADDHGSEHTVDGVKYSSELHIVHWNSEKYSSFSEAAEKPDGLAIIAVFIKAGQANPGLQKVIDALSSIKTKGKKAPFANFDPSLLIPQSSDYWSYHGSLTHPPLHESVTWIIYREPISASSEQLAKFRSLLSTAEGEKASSILHNHRLPQPLKGRQVKASFK
What is the function of this protein?
Catalyzes the reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase 1, Carbonate dehydratase I, Carbonic anhydrase I, CA-I.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MZRA_SALA4
Sequence: MLKPRITARQLIWISAFLLMLTILMMTWSTLRQQESTLAIRAVNLGASMPDGFSVLHHLDANGIHFKSITPKNDMLLITFDSPAQSAAAKTVLDQTLPHGYVVAQQDDDNETVQWLSRLRESSHRFG
What is the function of this protein?
Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.
What are the official names of this protein?
Modulator protein MzrA.
What is the protein family that this protein belongs to?
Belongs to the MzrA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CYB_NEGBR
Sequence: MAINIRKTHPLLKIMNHALIDLPAPSNISLWWNFGSLLGLCLIIQILTGLFLAMHYTADISMAFSSVVHICRDVNYGWLIRNIHANGASLFFICVYLHIARGLYYGSYLYKETWNIGVILLFLLMATAFVGYVLPWGQMSFWGATVITNLLSAFPYIGNMLVQWIWGGFSVDNATLTRFFAFHFLLPFLILALTVIHLLFLHETGSNNPLGINSDADKISFHPYFSYKDLLGFFVMIFLLATLALFTPNLLGDAENFIPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLFSIFILMLVPLLHTSKQRSIIFRPLTQIFFWFLVANSIILTWIGGQPVEQPFIMVGQIASISYFSLFLIIMPFTSWCENKILSLN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL17_CHLTA
Sequence: MQHARKKFRVGRTSSHNRCMLANMLKSLIHNERIETTLPKAKELRRHADKMITLAKKNTLAARRLAVGRLMVRYNTLTSKEARQVKAGDLSAYNVDRRVIGKLFDVLATRFSSRNGGYTRILKLQNRVGDNAQKCIIEFLA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: GFA1_SCHPO
Sequence: MCGIFGYINYLVERDRGYILKTLVKGLKRLEYRGYDSSGCAVDGDEGEDFIMFKEVGNVSKLEASIKGSNVNKSTKFINHCAISHTRWATHGIPSPINCHPQRSDPHSEFIVVHNGILTNYRELRTVLESRGMVFESETDTECVAKLAKFIYDTTPGVDFTSLAKLVFRELEGAYALLIKSSHYPGEVVATRRGSPLIVGVKSEQKLKVDFVDVEFPEPAEGLPGTPKPTSLHPVFSNPATNGMLRGDKPDLLHRAQSRAFVSGEGVPGPIEYFFASDATPIIEYTKRVMFLEDDDIAHVRDGELHVHRLRREGGGSTTRTIETLEMEIASVMKGNYDHYMIKEICEQPDSLLNTMRGRVNFVNRLVTLGGLESYYDIIRKSRRLIFVACGTSYHSCVAVRPLFEELTNIPVVVELASDFVDRCPSVFRDDTFIFVSQSGETADSLLALQYTLENGALAIGVVNCVGSSISRKTHCGVHINAGPEICVASTKAYTSQYVALVLMALYLSRDSVSRLERRNEIIDGLAEIGEKVQETLHLNAAIKQTAIEQLINKDKMLIIGRGYHYATALEGALKVKEISYTHAEGVLAGELKHGVLALVDNDMPIVMLLPDDYNFPKAWNAFEQVRARGGKPIIITDKKLDNLEGFTIIKVPKTVDCLQGILNVIPFQLLSYWLAVKRGHNVDQPRNLAKSVTVE
What is the function of this protein?
Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
What are the official names of this protein?
Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing], GFAT, D-fructose-6-phosphate amidotransferase, Hexosephosphate aminotransferase.
Protein: ANGL2_HUMAN
Sequence: MRPLCVTCWWLGLLAAMGAVAGQEDGFEGTEEGSPREFIYLNRYKRAGESQDKCTYTFIVPQQRVTGAICVNSKEPEVLLENRVHKQELELLNNELLKQKRQIETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENRILNQTADMLQLASKYKDLEHKYQHLATLAHNQSEIIAQLEEHCQRVPSARPVPQPPPAAPPRVYQPPTYNRIINQISTNEIQSDQNLKVLPPPLPTMPTLTSLPSSTDKPSGPWRDCLQALEDGHDTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGVYWAEFRGGSYSLKKVVMMIRPNPNTFH
What is the function of this protein?
Induces sprouting in endothelial cells through an autocrine and paracrine action.
What are the official names of this protein?
Angiopoietin-related protein 2, Angiopoietin-like protein 2.
What are the subcellular locations of this protein?
Secreted.
Protein: Y3913_SHEON
Sequence: MLIEIPNVFSKQEVNQLREQLDARTWIDGNQTSGMMASTRKRNQQLDKDDPVALQIGELIMARLLAHPLFVSAALPLQFYPPLFNRYQGGDTFGYHIDNAIRSTSDGMVRTDLSATLFLSELNAYEGGELVIQDTYGQQSIKLAAGSLVLYPSTSLHQVTPVTSGERTSAFMWLQSMVRDEGQRRLLFQLDQSIQTLTAQQAAEQELFNLTGVYHNLLRRWSEL
What are the official names of this protein?
PKHD-type hydroxylase SO_3913.
Protein: TM254_PONAB
Sequence: MATAAGAAYFQRGSLFWFTVITLSFGYYTWVVFWPQSIPYQNLGPLGPFTQYLVDHHHTLLCNGYWLAWLIHVGESLYAIVLCKHKGITSGRAQLLWFLQTFFFGIASLTILIAYKGKRQKQT
What are the official names of this protein?
Transmembrane protein 254.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PTN11_MOUSE
Sequence: MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLVDQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQRSFR
What is the function of this protein?
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:14967142).  Positively regulates MAPK signal transduction pathway (By similarity).  Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity).  Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity).  Dephosphorylates CDC73 (By similarity).  Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (PubMed:29644115).  Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (By similarity).
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase SYP, SH-PTP2, SHP-2, Shp2.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_LEPIN
Sequence: MNLQDVILTPIVTEKSQDLETIGANSKKGTRMVKYTVKVHIDANKTLIKEAFKKIFKVTPSSVNVQVYRGKIKRFRNMPAARPHWKKAIVTFRDGASIDFAKEA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: NANA_STAA2
Sequence: MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQKKQVFKVAKEAVGDKVKLIAQVGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIRDYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEKIVGVKYTAPNFFLLERIRKAFPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSNDIIETVLSMGIYPTLKEILRHRDIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP3_BACHK
Sequence: MADWLIGIIMGAVEGLTEFLPVSSTGHMILTGHLIGFDDDRAKVFEVVIQLGSILAVVVIFWKRLWSLVGIGKVTDGPSLNLLHIIIGMIPAGVLGVLFHSAIKEVLFGPGPVVISLVAGGILMIVAEKFSKPSTARTLDEITYKQAFTIGMFQCLALWPGFSRSGSTISGGLLARVSHTAAAEYTFILAVPMMVAASGLDLIKSWDILSTADIQLFATGFITAFVVAMLAIVSFLKLLSRVKLTPFAYYRFILAAVFYFFIM
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 3, Bacitracin resistance protein 3, Undecaprenyl pyrophosphate phosphatase 3.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.