PharMolix/UniProtQA huggingface dataset:
Protein: SUFU_HUMAN
Sequence: MAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH
What is the function of this protein?
Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:27234298, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:28965847).  Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597).  Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340).  Part of a corepressor complex that acts on DNA-bound GLI1.  May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340).  Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340).  Negative regulator of beta-catenin signaling (By similarity).  Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:24311597, PubMed:28965847).  GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:24311597, PubMed:28965847).  Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:24311597, PubMed:28965847).  When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:24311597, PubMed:28965847).  Required for normal embryonic development (By similarity).  Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).
What are the official names of this protein?
Suppressor of fused homolog, SUFUH.
What is the protein family that this protein belongs to?
Belongs to the SUFU family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MEPA_SALPA
Sequence: MKKTAIALLAWFVSSASLAATPWQKITHPVPGAAQSIGSFANGCIIGADTLPVQSDNYQVMRTDQRRYFGHPDLVMFIQRLSHQAQQRGLGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRWSQAQLLRPQALDLVSRDGKHVVPSRWSSDIASLIKLAAQDNDVTRIFVNPAIKQQLCLDAGSDRDWLRKVRPWFQHRAHMRVRLRCPADSLECEDQPLPPPGDGCGAELQSWFEPPKPGTTKPEKKTPPPLPPSCQALLDEHVL
What is the function of this protein?
Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands.  Likely plays a role in the removal of murein from the sacculus.
What are the official names of this protein?
Penicillin-insensitive murein endopeptidase, D-alanyl-D-alanine-endopeptidase, DD-endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M74 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL17_PROMM
Sequence: MRHQCRVPKLGRPTDQRKAMLRGLTTQLIREGRVTTTKARAKALRDEAERMITLAKNGSLASRRRAIGYIYDKQLVHALFDKAQDRYGDRQGGYTRIIRTVPRRGDNAEMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: TRHDE_MOUSE
Sequence: MGEDDAALRASGRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSIVALLAVTMLAVLLSLRFDECGASAAMPGTDGGLGGFPERDSNSSFPGSARRNHHAGGESSQRESGEVGTPGTPSAQPPSEEEREQWQPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQVAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYVIHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPAWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALRRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRILITQQHFIYDIGAKTKALQLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRIAYLDRGSWILGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAALIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPRNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKSYDGVASASFSRAVETVEANVRWKRFYQDELFQWLGKAMRH
What is the function of this protein?
Specific inactivation of TRH after its release.
What are the official names of this protein?
Thyrotropin-releasing hormone-degrading ectoenzyme, TRH-DE, TRH-degrading ectoenzyme, Pyroglutamyl-peptidase II, PAP-II, TRH-specific aminopeptidase, Thyroliberinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: NUDL_YERP3
Sequence: MSELITGQYLSEFINRFQLQLPQPDNVLTHSHYFSATNRRAAVLIPIICRPEPTLLLTRRADHLRKHAGQVAFPGGKADPDDQSLISTALREAEEEVAIPASVVHVLGKLAPLNSSSGYHVTPIVGLVPANIPFYGNDEEVAGLFEIPLHEALSLSRYHSLDIHREGINHRVYLSWYENQFIWGLTATIIRHLAQQVSI
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Uncharacterized Nudix hydrolase NudL.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Protein: KCY_BACAC
Sequence: MDKRISIAIDGPAAAGKSTVAKVVAKKLSYVYIDTGAMYRTITYAALEQKVDIENEEQLMEVVKNVKIEFQQGENTQLVFLNGQDVSEVIRTPEVTNRVSIVAKHRLVREEMVRRQQELAEKGGVVMDGRDIGTHVLPDAEVKIFMLASVEERAERRHLENMNKGFDSNLEQLKEEIAQRDKLDSEREVSPLKKADDALELDTTSLSIEEVVQKIMGIVLGVFAK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE2_HPV49
Sequence: MEALNARFNVLQEMLMDIYESGKEDLETQIEHWKLLRQEQALLFFARKHSIMRLGYQPVPPMAVSETKAKQAIGMMLTLQSLQKSPFGKEKWTLVNTSLETYNAPPAQCFKKGPYNIEVIFDGDPENLMVYTAWKEIYFVDSDDMWQKVQGEVDYAGAYYKDGTIKQYYVTFADDAVRYGTSGQYEVRINNETVFAPVTSSTPPSTGLRESSNASPVHDTVDETPTSTTATTTTFSTTTATATATGAPELSSKTGTRKGRYGRKDSSPTAASNSRKEVSRRRSRSRTRTRRREASTSRSQKASRSRSRSRSTSRGSRGSGGSVTTSRDSSPKRTRRGRGRGGRSRRSPTPTSTSKRERRRSRSRGGEPVSGGVGISPDKVGSRVQTVSGRHLGRLGRLLEEASDPPVILLRGDPNILKCYRYRDKKRKLGLVKHYSTTWSWVGVDGNERIGRSRMLLSFTSNSTRSQYVKIMKLPKGVEWSFGNFDKL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: GUN_PHAVU
Sequence: MGYHSVFIAVFLWSSMVCHNGLAMMDDGKLTSSSGPPNYDYADALAKAILFFEGQRSGKLPSSQRVKWREDSALSDGKLQNVNLMGGYYDAGDNVKFGWPMAFSTSLLSWAAVEYESEISSVNQLGYLQSAIRWGADFMLRAHTSPTTLYTQVGDGNADHNCWERPEDMDTPRTVYKIDANSPGTEVAAEYAAALSAASIVFKKIDAKYSSTLLSHSKSLFDFADKNRGSYSGSCPFYCSYSGYQDELLWAAAWLYKASGESKYLSYIISNQGWSQTVSEFSWDNKFVGAQTLLTEEFYGGKKDLAKIKTDAESFICAVMPGSNSRQIKTTPGGLLFTRDSSNLQYTTSSTMVLFIFSRILNRNHINGINCGSSHFTASQIRGFAKTQVEYILGKNPMKMSYMVGFGSKYPKQLHHRGSSIPSIKVHPAKVGCNAGLSDYYNSANPNPNTHVGAIVGGPDSNDRFNDARSDYSHAEPTTYINAAFVASISALLAKT
What is the function of this protein?
Involved in ripening fruit process.
What are the official names of this protein?
Endoglucanase, Abscission cellulase, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 9 (cellulase E) family.
Protein: SWF1_SCHPO
Sequence: MDFFYKYLALVAIASLMVFILLFGQIPKLKYTVIGKLNRFFMVTIPYHLHVLDSRYADGRCSAAMRSLSNYVLYKNNPLVVFLYLALITIGIASFFIYGSSLTQKFSIIDWISVLTSVLLPYISLYIAAKSNPGKIDLKNWNEASRRFPYDYKIFFPNKCSTCKFEKPARSKHCRLCNICVEKFDHHCIWINNCVGLNNARYFFLFLLCTIQLLFHSILRLGYHFNALRDMRQYPSFLRSWWFAIKSEGELGSVFLISLICSVLVLCLLGYEFFLVYAGYTTNESEKWSDLAHLVKNRKVYMYYENGSQLLALDKDASNDAILVTSMSQIDNIYDNGFYNNFFSLVFPYRHLYSTT
What is the function of this protein?
Palmitoyltransferase that targets several endosomal SNAREs.  Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain.  May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).
What are the official names of this protein?
Palmitoyltransferase swf1.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CBBR_SINMW
Sequence: MRNVSLRQLRTVEAVCRLGKINLAAEALGLTGPALTLQIQHLERDTGVALFDRTRGGMVPTAYGLAFLEAARAVEDSLAALEDSIGAISGLRTGRLRLGVVSTGKYFAPQLIAAFRDQVPAVEINLFIGNRAEIIAKLRDHEIDIALMGRPPRDFEVRAQVFGDHPLVFIAPAGHPLAGVLEISRERIAREQFLVREKGSGTRISLEIFLSDTPHELEELGTEIASNETIKQAVIAGLGIAFISAHTIEQEVKLGRLVILDVIDTPIRRQWFTVSRLDRAATPAMQAFEQFVLSSGARYLPVVSKPYPANAFG
What is the function of this protein?
Transcriptional activator for the cbb operon for RuBisCO and other Calvin cycle genes.
What are the official names of this protein?
HTH-type transcriptional regulator CbbR, RuBisCO operon transcriptional regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: RRF_SYNJB
Sequence: MELAEIEELMNKAVQATQRSFNTVRTGRANSSLLDRIQVEYYGVPTPLKALASLTTPDSSTLLIQPFDPSTLAAIERAIVASDLGLTPSNDGKVVRLTIPPLTEERRKELSKQVAKLAEEGRVSIRNIRRDGIDSVRKREKNGELSEDESKSLQDDIQKLTDRYIKKIDELLAEKEKELTTL
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCMB_PARDP
Sequence: MKALLIRDLRLATRAGGGFGLALAFFLIVCTLVPFGVGPEGGTLSRIAPGILWVGALLSCLLSLDRIFALDFEDGSLDLLATAPLPLEGAVAIKALAHWLVTGLPLALSAPVFGLLLHLPGPAYPWLVASLLLGTPALSMLGAFGAAVTVGLRRGGLLLSLLVLPLYVPTLIFGAEAVRRGAAGADPMTALVFLAAITLATLALAPFAAAAALRVNLR
What is the function of this protein?
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
What are the official names of this protein?
Heme exporter protein B, Cytochrome c-type biogenesis protein CcmB.
What is the protein family that this protein belongs to?
Belongs to the CcmB/CycW/HelB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL18A_METAC
Sequence: MVMMKSFIVKGKFKAGSTWEKFTKKIESQNEKNATDKTYSIFGSKHGVKRSQVQIESVAEE
What are the official names of this protein?
50S ribosomal protein L18Ae, 50S ribosomal protein L20e, 50S ribosomal protein LX.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
Protein: PPZF_METRR
Sequence: MSAHPGKPGRYYLISYPRTASNLLLKILALDSQPNFSSGEVDGGYFFMPADDILIEPRIRARSIGDWTADERAQVKESFQACFEAQQQWLEATESQGRSVFVKEHTVFFADPTARSDLQFGPSPTREPAWTVEYAGGSTHSKLNITVLPDEFLLTWLPTFLIRHPALAFPSLYRTVIKREGKESAAADNFASLLTTVEWSRSLYDFYVQNRESLPCSPDQSLEWPMILDADDIIAHPATVALYCNKIGMDPRKLCFHWDQFKSEELSQIEPNQLAMRMSLYQSTGIDTSKSSRGINVDDEASKWRSEFGIAVGDHIEKLVRGAMADYEYLRARRLRADRG
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of pyrrolopyrazines, secondary metabolites showing insecticidal activity (PubMed:30452111).  The single multifunctional NRPS ppzA is responsible for the biosynthesis of peramine (PubMed:30452111).  The condensation domain of ppzA is proposed to catalyze formation of a peptide bond between 1-pyrroline-5-carboxylate and arginine (By similarity).  The methylation domain of ppzA would catalyze the N-methylation of the alpha-amino group of arginine (By similarity).  The reductase domain is proposed to be responsible for reduction of the thioester and the cyclization to form an iminium ion resulting in release from the peptide synthetase (By similarity).  Deprotonation of this intermediate and oxidation of the pyrroline ring would give rise to peramine (By similarity).  This final oxidation to give the pyrrole functionality may be spontaneous (By similarity).  In Epichloe species that produce only peramine, the peramine synthetase gene is not localized in a gene cluster, in contrast to Metarhizium rileyi that contains additionnal pyrrolopyrazine biosynthesis genes (Probable).  The 2-oxoglutarate-Fe(II) type oxidoreductases ppzC and ppzD could be candidates for conversion of proline into an oxidized derivative to be used by the ppzA A1-domain as substrate (Probable).  The other ppz genes encode proteins predicted to derivatize peramine into more complex pyrrolopyrazine metabolites (Probable).
What are the official names of this protein?
Pyrrolopyrazine biosynthesis cluster protein F.
Protein: GUN17_ORYSJ
Sequence: MAAAGGAVLLLVLATATSVTGQHDYSDALHKSILFFEGQRSGRLPPDQRLRWRRDSALNDGATAGVDLTGGYYDAGDNVKFGFPMAFTATLMSWGLIDFGRSFGAHAAEAREAVRWATDYLMKATATPNTVYVQVGDAFRDHSCWERPEDMDTPRTVYKVDPSHPGSDVAAETAAALAAASIVFRDADPDYSNRLLDRAIQVFEFADKYRGPYSSSLHAAVCPCYCDYSGYKDELLWGAAWLHKASRRREYRDYIKRNEVVLGASEAINEFGWDNKHAGINVLISKEVLMGKDEYFQSFRVNADNFICTLLPGISNHPQIQYSPGGLLFKVGNSNMQHVTSLSFLLLAYSNYLSHANVRVPCGTSSASPVQLRRVAKRQVDYILGDNPLRMSYMVGYGSRYPLRIHHRGSSLPSVAAHPAQIGCKAGATYYASAAPNPNLLVGAVVGGPSNTSDAFPDARAVFQQSEPTTYINAPLLGLLAYFSAHPNLAQSDLLYD
What are the official names of this protein?
Endoglucanase 17, Endo-1,4-beta glucanase 17, OsGLU13.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 9 (cellulase E) family.
What are the subcellular locations of this protein?
Secreted.
Protein: BETA_PSEP1
Sequence: MSQEFDYIIVGAGSAGNTLATRLTEDAGVTVLLLEAGGPDYRFDFRTQMPAALAFPLQGRRYNWAYETDPEPYMDGRRMECGRGKGLGGSSLINGMCYIRGNAMDFDGWAELPGLEDWTYLDCLPYFRKAETRDIGPNDYHGGDGPVSVATPKAGNNPLFHAMVEAGVQAGYPRTEDLNGYQQEGFGPMDRSVTKNGRRSSTARGYLDQAKKRPNLTIVTHALTDRVLFDGKRAVGVTYLVGDSEERVEARARKEVIVSSGAIASPQLLQRSGVGPRALLESLDIPVVHDLPGVGENLQDHLELYLQYACTQPVSLYPSLLWWNQPAIGAEWLFNGTGIGASNQFEAGGFIRTRPEFKWPNIQYHFLPVAINYNGSNGVKEHGFQAHMGSMRSPARGRIQAKSKDPRQHPSILFNYMSTEQDWQEFRDGIRLTREIMAQPALDPYRGREISPGAHVQTDEELDKFIREHAETAFHPSCSCKMGTDDMAVVDGEGRVHGMKGLRVVDASIMPLIITGNLNATTIMIAEKISDKIRGRKPLPRSTAKYYVAGDAPVKGKPMREVKQG
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: RNC_CAUVN
Sequence: MDRRVAAVGDLERRIGHRFEDRELLERALTHASVGDGAKKVRDNEVLEFIGDRVLGLLAAEALAQRFPKAKEGELAPRLNALVSRETCARVARKAELGPALRLSASSSKIGGRETDSILAGATEALMAALYQDGGLEAARKVFLDLWNDEFDRAGEGRPRDPKTALQEWAQGQGRPLPTYRVLDRTGPDHAPVFTVEVSVTGVDPAIAKGKSRQEAEKAAAKALLEREGAG
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_SHEPC
Sequence: MGQKVHPNGIRLGITKPWISTWYADKSDYANNLNSDWEVRKFLVEKLQAASVSKIVIERPAKSIRVTIHTARPGVVIGKKGEDVEVLRAAVSKLAGTPAQINIAEIRKPELDAKLVADSIAQQLERRVMFRRAMKRAVQNAMRIGAQGIKVQVSGRLGGAEIARDEWYREGRVPLHTLRADIDYSTSESHTQYGVIGVKVWIFKGEVLDGMLPQIEEPKQQQPKRKPRGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: GLGA_VIBVU
Sequence: MATNPLSILFVASEVEGLIKSGGLADVAKALPEALVNLQHDARIAIPAYTAIPDVCDDEVILDTHLETWPHTHYQVKKRFLGDNPVYLIACGHYFDRPSMYAENNQAYTDNGERFAFFSAACLDMLPKIGFQPDIVHANDWHTGLVPFLLKHRYGQDPFFAQTKSILSIHNAVFKGVFHYDEMQCLPEFHCRNVPDAAVSSTHMTMLKAGVMNADKINAVSPTYAEELKTELGSHGMAWEFQQRAGDLVGILNGCDYSAWHPDTDSYLPINYKATKQSMVRGKNGCKRALQEQVGLPIKDVAMFGMVCRLTHQKGVHYLLPVLTEFLKLDVQLVLVGTGDPLLAAQLRDVAAQFGEKFVFVEAYNNQLAHLVEAASDFFLMPSEFEPCGLNQIYSMAYGSLPIVRGVGGLKDSVCDYDVNPETATGFVFYEPTAQALLITMQRALLLYAQNLTELRRVQLYAMERDFCWNKAAEQYVELYRSALK
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: HIS4_BRASB
Sequence: MILFPAIDLKNGQCVRLEQGDMARATVFNLDPAAQAKSFADQGFDYLHVVDLDGAFAGKPMNAQAVEAMLKVVKMPVQLGGGIRDLKTVEAWLNKGITRVIIGTAAVRDPELVKTAAKAFPGRVAVGLDARDGKVAVEGWAETSEVTALDIAKRFEDAGVAAIIFTDIARDGLLKGLNLDATIALGDAVSIPVIASGGLASIEDVKAMLTPRARKLEGAIAGRALYDGRLDPAEALALIRAARKAGA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1775_VIBCM
Sequence: MSCYCGNTQPYSQCCEPIHLNPHSAQVPEQLMRARFSAHILKNVEFVIETYHPSCQASNERDAISESVHSHWLRLEIISTQMGATPNEGFVHFKAFLDQEGKVFCLEERSRFLKENNCWFYIDGEFPAAIKQGRNDPCACGSGKKYKKCCG
What are the official names of this protein?
UPF0225 protein VCM66_1775.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: RL11_WOLPM
Sequence: MSVIVAKINLLMEAGKAVPGPKIASVLGPRGIPVPKFCEAFNKVTSAANANYKVGDLVTVRISIKDDRSHDFTVSGPPVAYLLKQEAKLSKSSGNPGKELVAKLPMSAIIKVAKCKMVDMKVDNEDSAVKMVVGTAKSMGIEVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ADMX_SERPL
Sequence: MKLRHLEIFYTVMTCGSLSRAAESLNISQPAASKSLKNAELKLGFKLFQRVRGKLLPSREALELFEKAQGIYQDLSNLRLLADNLARDPRAKFTLGCLPCLGLSLVPEIATDFYQQNSNLVMTLTAEHTETLVKKLDLREIDLALTMQPVQQGDIMATLIAEVPLVYVDKDYRQGAVEIDSIDQQRWISPGLDSLSTAIAAHRVFPATGLNVETCYMAMEFVKRGVGCCITDIFSARHSLTPEMIHQISPPMKIDLYLLRRADASLSPVTQKFVDFLCKRLRNELREINLELYPGNKKSIVSPV
What is the function of this protein?
Positively regulates the biosynthesis of andrimid, a broad-spectrum antibiotic, by activating the expression of the adm biosynthetic gene cluster (PubMed:26914969, PubMed:30500953).  It specifically binds to a region within the adm promoter (PubMed:30500953).
What are the official names of this protein?
HTH-type transcriptional regulator AdmX.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_COXBN
Sequence: MISIDVQHATQFEDLPSLSNIEQWVETALQFIVTDKNKSALTIRFIDKEESTELNEHYRHKKGPTNVLSFPDEPIPGFPSESFGDLAICAPLVAEEAHAQHKTTEAHFAHLITHGFLHLLGYDHVENEDAEEMENLEIKILSQLGFENPYEE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNY_STAAB
Sequence: MNLLSLLLILLGIILGVVGGYVVARNLLLQKQSQARQTAEDIVNQAHKEADNIKKEKLLEAKEENQILREQTEAELRERRSELQRQETRLLQKEENLERKSDLLDKKDEILEQKESKIEEKQQQVDAKESSVQTLIMKHEQELERISGLTQEEAINEQLQRVEEELSQDIAVLVKEKEKEAKEKVDKTAKELLATAVQRLAADHTSESTVSVVNLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRREIARTALVNLVSDGRIHPGRIEDMVEKARKEVDDIIREAGEQATFEVNAHNMHPDLVKIVGRLNYRTSYGQNVLKHSIEVAHLASMLAAELGEDETLAKRAGLLHDVGKAIDHEVEGSHVEIGVELAKKYGENETVINAIHSHHGDVEPTSIISILVAAADALSAARPGARKETLENYIRRLERLETLSESYDGVEKAFAIQAGREIRVIVSPEEIDDLKSYRLARDIKNQIEDELQYPGHIKVTVVRETRAVEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y, Conserved virulence factor A.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: YIGB_SHIFL
Sequence: MRFYRPLGRISALTFDLDDTLYDNRPVILRTEREALTFVQNYHPALRSFQNEDLQRLRQAVREAEPEIYHDVTRWRFRSIEQAMLDAGLSAEEASAGAHAAMINFAKWRSRIDVPQQTHDTLKQLAKKWPLVAITNGNAQPELFGLGDYFEFVLRAGPHGRSKPFSDMYFLAAEKLNVPIGEILHVGDDLTTDVGGAIRSGMQACWIRPENGDLMQTWDSRLLPHLEISRLASLTSLI
What is the function of this protein?
Catalyzes the dephosphorylation of flavin mononucleotide (FMN).
What are the official names of this protein?
Flavin mononucleotide phosphatase YigB, FMN phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
Protein: PXPA_BURVG
Sequence: MEIDLNADLGEGCGSDEALLDLVTSANIACGWHAGGANAMRDCVRWAVQKGVSIGAHPSFHDPENFGRKEMQLPPGDIYAGVLYQLGALSAIAQAEGGRIAHVKPHGALYNQAARDPTIADAVVSAIHDFDPSLSVFGLANSVFVAAARHAGLVAIEEVFADRGYRADGTLVPRSQPGALIDDEDAVLARTLDMVRERQVRAVTGEWVPLNAQTVCLHGDGPHALAFAKRIRAALETAGIDVIAPGALQAGEDA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: DUS2_MOUSE
Sequence: MPIAMGLETACELECAALGALLREPREAERTLLLDCRPFLAFCRSHVRAARPVPWNALLRRRARGTPAAALACLLPDRALRARLGRGELARAVVLDESSASVAELPPDGPAHLLLAALQHEMRGGPTTVCFLRGGFKSFQTYCPDLCSEAPAQALPPAGAENSNSDPRVPIYDQGGPVEILPYLYLGSCNHSSDLQGLQACGITAVLNVSASCPNHFEGLFHYKSIPVEDNQMVEISAWFQEAISFIDSVKNSGGRVLVHCQAGISRSATICLAYLIQSHRVRLDEAFDFVKQRRGVISPNFSFMGQLLQLETQVLCH
What is the function of this protein?
Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:16288922).  Can dephosphorylate MAPK1 (PubMed:16288922).
What are the official names of this protein?
Dual specificity protein phosphatase 2, Dual specificity protein phosphatase PAC-1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Nucleus.