PharMolix/UniProtQA huggingface dataset:
Protein: IDI_SACEN
Sequence: MEQVVLLNDSGQAIGVTDKATVHHLDTPLHLAFSCYVFNGRGQLLLTQRAHEKRTWPGVWTNTCCGHPAPQEAMPEAITRRLGEELGLTVRDLTLVLPRFRYRAVMGNGVVENEICPVFAAFTDDEPAPNREEVAGTAWADWSGFSAEVLAGTTDISPWCRQQVAELVELGANPAEWPAADPADLPDAAVIAAG
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPB41_XENLA
Sequence: MTTEKGLLAEAESPPQDQKQEGEEEVESCTTQPVVGSGDKDPETEQSQESPSTTSPSTRKSKDRHSQGKGLSRLFSSFLKRPKSQVSSDEKEVELLGEKGQDQKDVDEGLGEQLEDDVFLKAPIAAPEPELRTDPSLDLHSLSSAETQPAQEEQKEDQDPEADCEDVEGKEPIKKPEGESKASHKVVRRSPNMRCKVTLLDDTVYECDLEKHAKGQDIFKKVCSHLNIVEEDYFGLAIWESPTCKVWLDPLKDIRKQVHGGPCEFTSNVKFYPPDPAQLSEDITRYYLCLQLRKDIFSGRLPCSFATLALLGSYTVQSEVGDYEEDLHGVDYVSEFKLSPNQTKDLEEKVGELHKSYRSMTPAQADLEFLENAKKLTMYGVDIHQAKDLEGVDIKLGVCSGGLMVFKDNLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYKAAKKLWKVCVEHHTFFRLTSTESIPKHRFLSLGSTFRYSGRTQAQTRHASALIDRPAPHFVRTGSKRASRSLDGAAVATPEASRTHRPVSAPVFPPEFPAVQRKTPGPRVEEMPKKTEEKPKEGMPNQRESPKDVKATQQDSPSPTVNGDKVKDLEKTQDEIIRHHASIRELKKSFMESVPAPRPSEWDKRLSTHSPFRTLSFNGQVQTGTDGPPLVKTQTVTISNATNGEKGEIPTKEVPLVHTETKTITYEAARSDDVNTDQEPGILLTAHTITSETTSSTTTTQITKTVKGGISETLIEKRIVITGDGDLDHDQVLVQAIKEAKEQHPDMSVTKGVVHQETEIA
What is the function of this protein?
Protein 4. 1 is a major structural element of the erythrocyte membrane skeleton.  It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction.  May be required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
What are the official names of this protein?
Protein 4.1, Band 4.1, Erythrocyte membrane protein band 4.1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Protein: PFKA_ECOBW
Sequence: MIKKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAIENMKRPFKGDWLDCAKKLY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase isozyme 1, ATP-PFK 1, Phosphofructokinase 1, 6-phosphofructokinase isozyme I, Phosphohexokinase 1.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYOE_ACIAD
Sequence: MLKKYLFLTKPGILFGNFITTLGGFFLAAQGHVDFLLLILTLLGTTFVVASGCVVNNVIDQDIDQKMERTQNRALVKKTVSPSTALIFAFILGIIGFGILWFWVNPYSFSFAIIGFVVYVGFYSLWTKRTSIHQTIIGSISGASPPVIGYTAVTHQFDVAALLIFLAYGLWQMPHSWAIAIYRFDDYKNAGIPILPVARSVYRTKVECLIYIVLFAAVLNGLYCFGYTNVFFLLTFNVLTAYWLYLSIIGFKAENDQLWAKRLFLFSVILITLLSLSFSFTYQSPAPNLPLF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NMD3B_RAT
Sequence: MESVRTLWLSVALALAVGSRVVRGHPQPCRVPTRAGASVRLAALLPRAPAARARVLAALATPAPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASIAFPEARPELRLLQFLAAATETPVVSVLRREVRTALGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDPGSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVPAAVLLGCSTARAHEVLEAAPPGPQWLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAVVHDMVELVAQALSSMALVHPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAVWVTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAEQERSGPKDELPATDGAGRWRRVRRAVERERRVRFLLEPGEAGGDRPWLCSNGPGLQAELRELELRIEAARERLRSALLRRGELRALLGDGTRLRPLRLLHAAPAES
What is the function of this protein?
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium.  Mediated by glycine.
What are the official names of this protein?
Glutamate receptor ionotropic, NMDA 3B, GluN3B, N-methyl-D-aspartate receptor subtype 3B, NMDAR3B, NR3B.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane.
Protein: YFMI_BACSU
Sequence: MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVTLISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVFIIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAFLGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLRTIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLSERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQNITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFSQLQFKKKVNKHISF
What are the official names of this protein?
Uncharacterized MFS-type transporter YfmI.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CHLD_ARATH
Sequence: MAMTPVASSSPVSTCRLFRCNLLPDLLPKPLFLSLPKRNRIASCRFTVRASANATVESPNGVPASTSDTDTETDTTSYGRQFFPLAAVVGQEGIKTALLLGAVDREIGGIAISGRRGTAKTVMARGLHEILPPIEVVVGSISNADPACPDEWEDDLDERIEYNADNTIKTEIVKSPFIQIPLGVTEDRLIGSVDVEESVKRGTTVFQPGLLAEAHRGVLYVDEINLLDEGISNLLLNVLTDGVNIVEREGISFRHPCKPLLIATYNPEEGAVREHLLDRVAINLSADLPMSFEDRVAAVGIATQFQERCNEVFRMVNEETETAKTQIILAREYLKDVKISREQLKYLVLEAVRGGVQGHRAELYAARVAKCLAAIEGREKVTIDDLRKAVELVILPRSSLDETPPEQQNQPPPPPPPPQNSESGEEENEEEQEEEEEDESNEENENEQQQDQIPEEFIFDAEGGLVDEKLLFFAQQAQKRRGKAGRAKNVIFSEDRGRYIKPMLPKGPVKRLAVDATLRAAAPYQKLRREKDISGTRKVFVEKTDMRAKRMARKAGALVIFVVDASGSMALNRMQNAKGAALKLLAESYTSRDQVSIIPFRGDAAEVLLPPSRSIAMARNRLERLPCGGGSPLAHGLTTAVRVGLNAEKSGDVGRIMIVAITDGRANITLKRSTDPESIAPDAPRPTSKELKDEILEVAGKIYKAGMSLLVIDTENKFVSTGFAKEIARVAQGKYYYLPNASDAVISATTRDALSDLKNS
What is the function of this protein?
Involved in chlorophyll biosynthesis.  Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.  The magnesium-chelatase is a complex of three subunits, CHLI, CHLD and CHLH.  The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP-dependent chelation step.  Does not bind abscisic acid.
What are the official names of this protein?
Magnesium-chelatase subunit ChlD, chloroplastic, Mg-chelatase subunit D, Mg-protoporphyrin IX chelatase subunit ChlD, Protein ALBINA 1, Protein PIGMENT DEFECTIVE EMBRYO 166.
What is the protein family that this protein belongs to?
Belongs to the Mg-chelatase subunits D/I family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MTNB_PHANO
Sequence: MSTTAQDVEALVHSDDPNHPANHICTLCAKFYTLGWVTGTGGGTSIRHEDKIYIAPSGVQKELMKPTDMFVMDFESKEYLRRPQVLKPSACTPLFMAAFERGAGCCIHTHSQWAVLVTLLVERDLGTEACFEIEEIEQIKGIPKGRGKQGNLGYYDRLRIPIIENTAHEEDLRESLEAAMERWPDSYAILVRRHGIYVWGDNVHKAKTQCESIDYILQLAVEMKKLGLPWTKS
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL349_YEAST
Sequence: MAPLNMEQGKRYAMLVNCSRGITFSFNKSYAPNLTVVYVHCLNTAALRPEYNPTTPSFAKILSNILKSVGLGIGAACSLTLAKSRGCVTMVAKIPAAPPYHHGYLIFLPADSFALVDMPSSCCVIFSTLSEQEKRTSTHKYAYDYVYPYIYIHYKPTARPFPAPNIAA
What are the official names of this protein?
Putative uncharacterized protein YLR349W.
Protein: MNTH_LISMO
Sequence: MKKDKTERTKQSWRKAQNAPSLSEVNNSVAIPKNAKFFRKLFAFMGPGALIAVGYVDPGNWATSIAGGSEFGYTLLSVILISNILAVLLQSLASKLGIVTGRDLAQASSDHFSKPFGFVLWILAELAIIATDIAEVIGSAIALNLLFGIPLIWGVCITALDIFLVLFLQHKGFRYIEVIVITLMVTILVCFGAEMVMSHPDMQAIAKGFIPQSEIVTNPAMLYIALGILGATVMPHNLYLHSSIVQTRQYARTKEGKKEAIRFSFIDSTFSLTIALLINASILILAAAAFYTTGQHNVAGIEDAYKLLNPTLGSSIASTVFAVALLASGQNSTLTGTLAGQIVMEGFLNIRLKPVVRRLLTRVLAIVPAVIITALYGANGINELLIFSQVILSMQLSFAVIPLVMFTSDKQKMGEFVNPTWLKIISWAVAIFIAVLNIYLLFYTLTSL
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MGSA_BURO1
Sequence: MSKPRIALIAHDAKKDEIVALAGQYRETLAQCRLVATGTTGGRIAAAHGLEVERKLSGPLGGDLQIGAEFADGRVDIVVFLRDPMTAQPHDPDITALVRACDVHDVPVATNVATARMLLDDLARNMQDVC
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: RL23_STRPF
Sequence: MNLYDVIKKPVITEKSMIALEAGKYTFEVDTRAHKLLIKQAVEAAFDGVKVASVNTVNVKPKAKRVGRYTGFTSKTKKAIITLTADSKAIELFAAEAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: MNMA_CHLCV
Sequence: MNKTVVVAMSGGVDSSVVAYLLKTTTPYKVIGLFMKNWEEEDSDGLCSTAKDYEDVERVAGQLDIPYYTVSFAKEYRERVFSRFLREYSKGYTPNPDVLCNREIKFDLLQRKVRELGGDFLATGHYCRLSSAAEGRHLLRGLDPQKDQSYFLCGTRRESLDNVLFPLGGMTKTKVRAIAEQARLATAQKRDSTGICFIGKRPFKSFLEKFVPNVEGDIVDYDSQKVVGRHEGAHYYTIGQRRGLDLGGSEKPCYVVGKDMEKNIVYIVRGEDHPLLYQTELTAKELNWFVSPESITRCSAKVRYRSEDEECEILHSDEDSEVRVRFSSPVKAITPGQTIAFYDGEKCLGGGVIEVSMTPH
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_FRATH
Sequence: MAKSVRSSKKKVKRVVPDAVAHIYSSFNNTIVTITDRQGNALSWATSGGSGFRGSRKSTPFAAQVAAERAADMALEYGVKNVDVLVKGPGSGRDSAIRALNAKNLKVTSITDVTPLPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: AMPA_NOSP7
Sequence: MTIQPSDKPLLEWAGDSLAIGLFEDAVELTGELATLDQKFSGVLKELIAEEEFKGKANSTIFTRVNPGRPVRKLILVGLGKPDALKLDTLRRAAAAVARVAKKQKSKILGFSFPLWNNDPAASAQAIAEGVELALYQDIRFKSEPEDKGSQIETVDLLGFSGQEAAITLANQIVSGVNLARELVAAPANAVTPITLAETAQAIAKDYGLQVEILEKEDCEKLGMGAFLGVAQASELPPKFIHLTYKPEGTPKKKLAIIGKGVTFDSGGLNIKGAGSGIETMKMDMGGAAATLGAAKAIAQIKPDVEVHFISAVAENMISGRAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYAEKLGLDAIVDLATLTGANVIALGDDIAGLYTPDDDVASQIEKAAQTSGEKIWRMPMEEKYFEGLKSGIADMKNTGPRPGGAITAALFLKQFVKETPWAHLDIAGPVWTDKENGYNGAGATGYGVRLLVNWVLGIGE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOC_TRIL1
Sequence: MADTNRAVEKLQGKFEASILEVKQDRGDWIVTVKKEDIVAVLAFLKQECKFDMLTDVTAVDYLGKAADRFMMVYQLTSVPFKDRLRIKAPVAEADCVIGSATQVYGSANWLEREVFDLFGIRFDKHPDLRRILMTPDWEGHPLRKDYPLQGPGREPYKGRLS
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MSCL_PHOV8
Sequence: MGKSSFLQDFKAFAMRGNVIDMAVGVIIGGAFGKIVSSIVADVIMPPIGLLVGGVNFTDLKLQLKPAEVVDGVEKAAVTLNYGNFLQATFDFIIIAFSIFLFIRLLAKLNRKKEEVPAPAAPPAPSKEEVLLTEIRDLLKEQAGKK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LPLT_ECOLI
Sequence: MSESVHTNTSLWSKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSKLVKANGLMEASTIAAILLGSVAGGVLADWHVLVALAACALAYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVLIFSLQHELLPAYALLMLIGVMGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGIYSLAVMIGIPVVPIGIGFGALFALAITALWIWQRRH
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLCA_ECO24
Sequence: MKTDTPSLETPQAARLRRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQLARSKAASASENT
What is the function of this protein?
Proton-coupled chloride transporter.  Functions as antiport system and exchanges two chloride ions for 1 proton.  Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
H(+)/Cl(-) exchange transporter ClcA.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ZN287_HUMAN
Sequence: MLASSKRMNSSSRSQILLRWKSDKAQSGPYNVEKEILTSRFLRDTETCRQNFRNFPYPDLAGPRKALSQLRELCLKWLRPEIHSKEQILELLVLEQFLTILPGEVRTWVKSQYPESSEEAVTLVEDLTQILEEEAPQNSTLSQDTPEEDPRGKHAFQTGWLNDLVTKESMTFKDVAVDITQEDWELMRPVQKELYKTVTLQNYWNMVSLGLTVYRPTVIPILEEPWMVIKEILEGPSPEWETKAQACTPVEDMSKLTKEETHTIKLEDSYDYDDRLERRGKGGFWKIHTDERGFSLKSVLSQEYDPTEECLSKYDIYRNNFEKHSNLIVQFDTQLDNKTSVYNEGRATFNHVSYGIVHRKILPGEKPYKCNVCGKKFRKYPSLLKHQSTHAKEKSYECEECGKEFRHISSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQHQTTHTGEKSYICNICGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQGANLTQHQRIHTGEKPYKCNECGKAFIYSSSLNQHQRTHTGERPYKCNECDKDFSQRTCLIQHQRIHTGEKPYACRICGKTFTQSTNLIQHQRVHTGAKHRN
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 287, Zinc finger protein with KRAB and SCAN domains 13.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YTFE_ECOSE
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVEVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMDHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP1_BACHK
Sequence: MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQAAELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEVKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYDRLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKELEKVATPDQKAIEEVSAFLNIEADKCIKSMVFKVDEKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEIKELLNCEVGSLGPIGVNGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTQPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKAVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEVKVEELQTYIANILK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase 1, Prolyl-tRNA synthetase 1, ProRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGCT2_HORVU
Sequence: MKITVHSSKAVKPEYGACGVAPGCTADVVPLTVLDKANFDTYISVIYAFHPPAPPNAVLEAGLGRALVDYREWAGRLGVDANGDRAILLNDAGARFVEATADVALDSVMPLKPTSEVLSLHPSGDDGPEELMLIQVTRFACGSLVVGFTAQHLVSDGRATSNFFLAWSQATRGVAVDPVPVHDRASFFHPREPLHVEYEHRGVEFKPYEKAHDVVCGADGDEDEVVVNKVHFSREFISKLKAQASAGAPRPCSTLQCVVAHLWRSMTMARGLDGGETTSVAIAVDGRARMSPQVPDGYTGNVILWARPTTTAGELVDRPVKHAVELISREVARINDGYFKSFIDFANSGAVEKERLVATADAADMVLSPNIEVDSWLRIPFYDMDFGGGRPFFFMPSYLPVEGLLILLPSFLGDGSVDAYVPLFSRDMNTFKNCCYSLD
What is the function of this protein?
Involved in the synthesis of hordatines (antifungal hydroxycinnamoylagmatine derivatives).  Specific for agmatine as the acyl acceptor, inactive towards tyramine and putrescine.  Has activity with the acyl donors 4-coumaroyl-CoA, cinnamoyl-CoA, caffeoyl-CoA, feruloyl-CoA, and to a lesser extent sinapoyl-CoA.
What are the official names of this protein?
Agmatine coumaroyltransferase-2.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: PVK2_LUCVE
Sequence: GSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, LucVe-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS6_METBU
Sequence: MLTKRIIPCLDVTLDASGGTVVKGVEFVDLKKAGDPVDLAKRYNEQGADELVFLDITASHEGRSTMIDVIERTANEVFIPLTVGGGINSVEDVRQILRAGADKVSVNTAAVKNPEFIREASNIFGSQCIVTAIDCKRNLDVENNQDKTILELEDGTLAWYEVVIYGGREPTGLDTVQWAKKVEELGSGEILLTSMNRDGTYDGFDIPITKKLSEELDIPIIASGGVGNPEHMYKGFVDGKADAGLAASIFHFGEYTVRDVKEALRAKNIPVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIMP1_HORSE
Sequence: MAPFAPLVSGILLLLWLTAPSRACTCVPPHPQTAFCSSEFVIRAKFVGTSEVNQTTLQRRYEIKMTKMFKGFSALGDAPDTWFVYTPAMESLCGYFHRSENRSEEFLIAGQLLDEKLYITTCSFVAPWNSLSSAQRQGFTKTYAAGCGECSVFPCSSIPCKLQSDTDCLWTDQLLTGSDKGFQSRYLACLPREPGLCTWQSLRPRTA
What is the function of this protein?
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor.  Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16.  Does not act on MMP14.  Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1.  Plays a role in integrin signaling (By similarity).
What are the official names of this protein?
Metalloproteinase inhibitor 1, Tissue inhibitor of metalloproteinases 1, TIMP-1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I35 (TIMP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL35_ACIBS
Sequence: MAKLKTRRGAAKRFKATANGFKRKQAFKRHILTKKSAKRIRQLRGCVMVHVSDVASVRRMCPYI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.