PharMolix/UniProtQA huggingface dataset:
Protein: RR3_OSTTA
Sequence: MGQKVHPIGFRIGVTQTHRSQWFAKPKDYAKLVEEDLLIREFAESRLPDAGISRINISRQVDRIEIEFFTARPRALVGAKGETLTQLRDEIKAKLPDTRNVALYVTKTQQPEMEAICIAENIAEQLEKRTPFRRTMRQAIMRARKAGAEGIKIQISGRLNGAEIARHEWAREGRVPLHTIRADIDYATARAQTIYGILGIKVWVCKGEKSC
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: OPY1_YEAST
Sequence: MIAGATAPSSQHEILIASNLIKKPSTSQNKTPTAQSSSGNNGAADGAPQGYHHHHHHHRHLWWPRTTDHQYWCVLRKNQFAYYKTRDEREAISVIPRFDILNFKISELDGILTVYTPSKDLIFKFPRGQNEKVGMELMHNWKIALEKFLSSPSGNESVTTGSDYDEEEDDDDLIVVDEKAGPSSSKHSCSLTMDEQLSREDKEFYRMFDPRNAEHQVCSGILYTKVKKKKLFNRAKWQKFNVELTNTSFNLYSFKTGKLKKSIKLDKIIDCIELDNNSKMKNDDTNFALITFDERLSFKAANDQDMVDWIINFKSGILIRKKLKAENI
What are the official names of this protein?
Protein OPY1, Overproduction-induced pheromone-resistant yeast protein 1.
Protein: SSRP_CLAMS
Sequence: MPRERGEKVVATNRKARHDYTIESTYEAGLVLTGTEVKSLRQGRASLVDGYAFVDAGEAWLDAVHIPEYNQGTWNNHPVRRKRKLLLHKEQILKIHSKVKEGGYTVVPLQLYFVDGRAKVELAIAKGKKEYDKRQTLRERQDKREADRAMSSHRRLGE
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RNZ_STRPF
Sequence: MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHIFGLPGFLSSRSFQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFHEFDDKSLGKIMETDKFVVYAERLAHTIFCMGYRVVQKDLEGTLDAEALKAAGVPFGPLFGKIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYGKGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKMVQDLEEVII
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: PXPA_ECO55
Sequence: MKIDLNADLGEGCASDAELLTLVSSANIACGFHAGDAQTMQACVREAIKNGVAIGAHPSFPDRENFGRSAMQLPPETVYAQTLYQIGALATIARAQGGVMRHVKPHGMLYNQAAKEAQLADAIARAVYACDPALVLVGLAGSELIRAGKQYGLTTREEVFADRGYQADGSLVPRSQPGALIENEEQALAQTLEMVQHGRVKSITGEWATVTAQTVCLHGDGEHALAFARRLRSTFAEKEIVVAA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: HXNY_EMENI
Sequence: MAPTAPPILDFSPFYGTDGAAKAKLVQQVRESCEYNGFFQITGHRIPRELQVRVMDAAKRFFALPLEEKMAIDKNLNSFNRGYELLRSQMLEVGTAPELKEGLYIGEEIGADHPYYINGRLNSGPNQWPATVPDAQEFRETSMEYYHAVYELAKDVLAVLALTLDVEESFFDPLTEGGVATMRMLHYPSQPKDEDEKLNRGIGAHTDFGCITLLLQDEVDGLQVLDAPSGQWLDVQPVLGAYVVNLGDLMMRMANDRYKSNIHRVINKSGRERYSIPFFFSGNPDHVCKCLPNCCKAGEQPKYPPITVEDMVRGAYKQSYGRAEAYKKELAEKAKAHKIEAASATAMVS
What is the function of this protein?
2-oxoglutarate-Fe(II) type oxidoreductase, part of the hnx cluster involved in the purine degradation (PubMed:29212709).  The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism (PubMed:29212709).  The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid (PubMed:29212709).
What are the official names of this protein?
2-oxoglutarate-Fe(II) type oxidoreductase hxnY, Nicotinate catabolism cluster protein hxnY.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: SIGA_MYCTO
Sequence: MAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKPASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHATKPRAPKDAQHEAATDPEDALDSVEELDAEPDLDVEPGEDLDLDAADLNLDDLEDDVAPDADDDLDSGDDEDHEDLEAEAAVAPGQTADDDEEIAEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA, Sigma-A.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICAL_SHEEP
Sequence: MNPTEAKAIPGSKQLEGPHSPNKKRHKKQAVKTEPEKKSQSTKPSVVHEKKTQEVKPKEHTEPKSQPKHPSDTRSKHAPKEKAVSKSSEQPPSEKSTKPKTKSQDEISGGGKSAVPAVAAAASAEPADKNKESKLLTSAVPVESKPSKPSAKSDMDTALDDLIDTLGEPEETKEDTTTYTGPEVSDPMSSTYIEELGKREVTLPPKYRELLNKEEGIAGPPPDSSKPLGPNDAIDALSSDFTCSSPTADAKKTEKEKSTEEALKAQSAGVIRSAAPPKEKRRKVEEDTMTEQALEALSASLGTRKPRPELDPSSIKEVDEAKAKEEKVKKCGEDEERVPSEYRLKPATDKDGKPLLPEAEEKPKPLSESELIDELSEDFDRSKCKEKQSKPTEKNRGIPGRCPRACARGCASDLHVFCAVSSTHSSSSEGMVPDDAVEALAGSLGKKEADPEDGKPVEDKVKEKAKEEDREKLGEREETIPPDYRLEEAKDKDGKPLPPKEVKEPLPPLSEDFLLDALSKDFTVPSDTSSPQFEDAKLSVVVSEVVSQTPAPTTQAAGPPRDSARDNKELDDALDQLSDSLGQRQPDPDEHKPVEDKVKEKAKAEHRDKLGERDDTIPPKYQHLLDDNKEGTPGKPKRSESPRHQRSPRHQRNLQVPRTPLTPSQGTWTAVPQLQKPQQTQQRTKTRSLLPSDKAPRNGGKAKDSTKAKEETSKPKADGKSTS
What is the function of this protein?
Specific inhibition of calpain (calcium-dependent cysteine protease).  Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue (By similarity).
What are the official names of this protein?
Calpastatin, Calpain inhibitor.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I27 (calpastatin) family.
Protein: GREA_LISMH
Sequence: MATEKVFPMTLDGKAKLENELQELKTVKRKEVVERIKIARSFGDLSENSEYDSAKDEQAFVEGRITTIENMIRNAQIIDAAEAHNGLVTLGNTVTFIELPDGEEETYTIVGSAEADPFEGKISNDSPIAKGLLGHKEGEEVTIQTPAGDMSVKIEKITAS
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RLMM_ESCF3
Sequence: MNKVVLLCRPGFEKECAAEITDKAGRQEIFGFARVKENAGYVIYECYQAEDGDKLIRELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELLKFCRKFTVPLRAALRDAGVLANYETPKRPVVHVFFIAPGCCYTGYSYSNNNSPFYMGIPRLKFPADAPSRSTLKLEEAFHVFIPADEWDERLANGMWAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFKFRPTRNNISWMVCDMVEKPAKVAALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYIQAQLDEHGINAQIQARQLYHDREEVTVHVRRIWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA_CAUVC
Sequence: MTSRPLAISAGDPAGVGAEIIAKAWRALRQDGPTFVVIGDAQLLASAGGGVKVRAVTRPQEAAQVFPDALPVLDIPVLSPVVYGRPSPSHAPQIIRWIETGVGLALSGAVSGLVTAPIAKAPLYEAGFQFPGHTEFLAELTAAASMVGARGPVMMLAAGDLRATLVTIHTALAKAPSALTTEAIINSGLVTAQALRKDFGIAEPRLAVAALNPHAGEGGALGREEIDIIAPAVEALRALGVQASGPAPADTLFHPEARARYDGVLCMYHDQALIPVKMLDFWGGVNITLGLPIVRTSPDHGTGFDIAGRGIARPDSLIAAIQLAAKIAARRGV
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_AGARV
Sequence: MANVQYYDVILKPVVTEKSMNAMAEKKYTFLVHPDANKTMIKEAVERMFEGTKVAKVNTMNCEGKNKRRGMVTGKTAKTKKAIVQLTADSKDIEIFAGL
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: ATPD_XANOP
Sequence: MSQALTLARPYGRAAFAIAREGGTFAPWSDALAFSAQVAGDPRVAALLLNPALGQEQAVTLLAPPQAGEDYLCFLGVLADAQRLSLLPEVAGLYEHLRAEAEHVVKATVTSAAAMSQTELDTIAAALKKRFGRDVDITTAVDASLIGGAVIDTGDVVIDGSLKGKLARLQSSLAH
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DTDA_HALMA
Sequence: MLGIVVSHADAASMHIGEHLRSLRDWETSVDETRPDDEGGGTVYQIDSVELREFEALHLDIENVAAAFDDPDLLVFASKHAGETDELLTAHHTGNFGVAEHGGEDGQFARACPGAHKAVVSALQRHAPPDYEVGMECTHHGPTAVGVPSMFVEVGSAEPQWEDPDAAEAAARAILDLADEPADRPRENGTRRHLLGVGGGHYAPRFERVVRETDWAVGHIAANWSLDALAEWADSDEERDTVLDRAFRASAADYALMEGDRPDLTAAIESLGYRVVSETFVQEATGVNLGLVEALEDAIRPVDEGLRFGALAPGYDGEWTVLDLPKELISDVRGVDSEALRDTIERQSIAYATEQNGTVVTGPIVCPATTELEAVVDPLVEILKQRFDSVERNADELVARETAFDPDLARTADIPEGPKFGKLASGESVEIDGEEIDPERFQRERIRRYTL
What is the function of this protein?
D-aminoacyl-tRNA deacylase with broad substrate specificity.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, D-tyrosyl-tRNA(Tyr) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DtdA deacylase family.
Protein: Y9I2_ENCCU
Sequence: MDSEARIKKIMEATGCSHDVARKAENESQGNLDLAIKIAGRKGNVLYSGGKSGLYVEERPSRKSITQYKNGILVEDKFYDFSVDDNIRLREMLEKKTFDASLLGLHGDTAEVIYTEKPDEEYRENSKAPEAKARPSFVGEGRRLGDSSREIPHVNIPDMLEIAKDGNVLFKVMIGSKRVTVRMLRSQTVGDFFDYIERYYDFGLVLSSNGKEIPPSHSVEEISNKLVLLSRR
What are the official names of this protein?
Uncharacterized protein ECU09_1820.
Protein: RL16_OENOB
Sequence: MLVPKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKRGGKVWIKIFPQKSYTSKGVGVRMGNGKGAPEGWVAPTKRGTIMFEVGGVSEAVAKEALRLAMHKLPVKAKIVSKAEASKEVNA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: ATPB_RICBR
Sequence: MKKNIGKITQIISAVVDVKFTNKGKLPQILNALECYNDKQRIVLEIAQHIGDDTVRCIAMNSTEGLVRGMEVVDTGSPISIPVGIETLGRIMNVVGEPIDGKGKIKGSSISSIYKSAPSFTQQSTDRNILVTGIKVVDLLAPYTKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYTVFAGVGERTREGNDLYHEMIDSGVINLEEPEKSKVALVYGQMNEPPGARARVALTGLTVAESFRDMNEGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGELQERITSTKHGSITSVQAIYVPADDLTDPAPATSFAHLDATTVLSRQIAELGIYPAVDPLDSTSQVLDPMIVGEEHYNVARKVQQILQTYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFHVAEVFTGAEGKFVNLADTIAGFKGLTEGKYDDLPEAAFYMVGTIEEALEKAKTLK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL34_FRATM
Sequence: MKRTFQPSNLKRKRTHGFRARMKTLSGRKVIRNRRAKGRAKLAA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RL18_CROS8
Sequence: MDKKSARIRRATRARRKLKELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PYRG_AGRFC
Sequence: MARYVFITGGVVSSLGKGIAAAALGALLQSRGYRVRLRKLDPYLNVDPGTMSPTQHGEVFVTDDGAETDLDLGHYERFTGRSATKTDNITTGRIYKNIIDKERRGDYLGATVQVIPHVTNEIKDFVTEGNDDYDFVICEIGGTVGDIEAMPFMEAIRQLGNDLPRGTAIYVHLTLMPYIPAAGELKTKPTQHSVKELQALGIHPDILLVRADREIPEAERRKLSLFCNVRPSAVIQALDVANIYDVPIAYHNEGLDSEVLAAFGIEPAPKPRLEQWEEVCNRIRTPEGEVTIAIVGKYTGLKDAYKSLIEALHHGGFANRVKVKLEWIESEVFEKEDPTPYLEKVNGILVPGGFGERGSEGKIMAAQFARERNVPYFGICFGMQMAVVEAARHLAGIENASSTEFGPTAEPVVGLMTEWVKGNELEKRSTKGDLGGTMRLGAYKAALKKDTKIAEIYGTTDISERHRHRYEVNVDYKDRLEECGLVFSGMSPDGVLPETVEYPDHPWFIGVQYHPELKSRPLDPHPLFASFVEAAVEQSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: TYRDC_ENTF3
Sequence: MKNEKLAKGEMNLNALFIGDKAENGQLYKDLLIDLVDEHLGWRQNYMPQDMPVISSQERTSESYEKTVNHMKDVLNEISSRMRTHSVPWHTAGRYWGHMNSETLMPSLLAYNFAMLWNGNNVAYESSPATSQMEEEVGHEFAHLMSYKNGWGHIVADGSLANLEGLWYARNIKSLPFAMKEVKPELVAGKSDWELLNMPTKEIMDLLESAEDEIDEIKAHSARSGKHLQAIGKWLVPQTKHYSWLKAADIIGIGLDQVIPVPVDHNYRMDINELEKIVRGLAEEQIPVLGVVGVVGSTEEGAVDSIDKIIALRDELMKDGIYYYVHVDAAYGGYGRAIFLDEDNNFIPYEDLQDVHEEYGVFKEKKEHISREVYDAYKAIELAESVTIDPHKMGYIPYSAGGIVIQDIRMRDVISYFATYVFEKGADIPALLGAYILEGSKAGATAASVWAAHHVLPLNVAGYGKLIGASIEGSHHFYNFLNDLTFKVGDKEIEVHTLTHPDFNMVDYVFKEKGNDDLVAMNKLNHDVYDYASYVKGNIYNNEFITSHTDFAIPDYGNSPLKFVNSLGFSDEEWNRAGKVTVLRAAVMTPYMNDKEEFDVYAPKIQAALQEKLEQIYDVK
What is the function of this protein?
Also involved in drug metabolism, being able to catalyze decarboxylation of levodopa (L-dopa) to dopamine.  In gut microbiota this enzyme is in fact exclusively responsible for the decarboxylation of levodopa, and thus reduces in situ levels of levodopa in the treatment of Parkinson's disease.  It was shown that abundance of bacterial tyrosine decarboxylase in the proximal small intestine - the primary site of levodopa absorption - contributes to interindividual variation in drug efficacy and can explain the requirement for an increased dosage regimen of levodopa treatment in Parkinson's disease patients.
What are the official names of this protein?
L-tyrosine decarboxylase, TDC, TyrDC, Levodopa decarboxylase, L-dopa decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. Tyrosine decarboxylase subfamily.
Protein: VATD_ANADE
Sequence: MSRAATTRMGLLEVRARRAVAGKGARLLRAKREVLASELWRLVHDVLEGRARLDEALRRAVKALELAKALEGEERLASLALPAARAVPLAVTVRRVWGVPTPSVAAPPLVRAADQRGSSPVSWGPSGAAAARHHEESLEVLLTIASKELHLARLGEEIQETSRRINALEQLVLPALRSEASRIAAALDERDREDAVRLRRFRARHPRPA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: TM221_MOUSE
Sequence: MGRSYGGRVLAAMTLLGIPAAVLVALAAQLLFQLQAGRAELRRVRTDGLHPELDPDAGLPEAAAGALLPLATALAALAQVLGLSCLLLAALCGHLGAELARGPGPGRSDWFLYDCRLLRHSALGLFCCGVSVYLAALAIYALLLFEIEAGAAAASILGSGALILVAIMTHTLFRAVQATRRGLRELSPPSFEDEPARPSEDSKSGCRAQPPQDEETETPIGAVTHQGSHF
What are the official names of this protein?
Transmembrane protein 221.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RLMD_SALPA
Sequence: MAQFYSAKRRVTTRQIITVKVNDLDSFGQGVARHNGKALFIPGLLPEESAEVIITEDKKQFARARVSRRLNDSPERETPRCPHFGVCGGCQQQHVGIDLQQRSKSAALARLMKHEVNDIIAGAPWGYRRRARLSLNCPPDKPLQMGFRKAGSSDIVNVEQCPVLAPQLAALLPRIRACLASLHGTRHLGHVELVQAGSGTLMILRHTAPLSAADKEKLERFSHSEGLSLFLAPFSEILETVSGEAPWYDSHGLRLAFSPRDFIQVNEAVNQQMVARALEWLDVRAEDRVLDLFCGMGNFTLPLATRAASVVGVEGVPALVEKGRENAIRNGLHNVTFFHENLEEDVTKQPWAKNGFDKVLLDPARAGATGVMRHIIKLKPIRIVYVSCNPATLARDSEALVNAGYEVTRLAMLDMFPHTGHLESMVLFERM
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: NOP10_NITMS
Sequence: MRFQLRKCSKCFQYTLKEICPKCKEQTISAHPAKFSPDDKYMRYRLAERYN
What is the function of this protein?
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
What are the official names of this protein?
Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
Protein: HPT_CANLF
Sequence: EDTGSEATNNTEVSLPKPPVIENGYVEHMIRYQCKPFYKLHTEGDGVYTLNSEKHWTNKAVGEKLPECEAVCGKPKNPVDQVQRIMGGSVDAKGSFPWQAKMVSHHNLTSGATLINEQWLLTTAKNLFLGHKDDAKANDIAPTLKLYVGKNQLVEVEKVVLHPDYSKVDIGLIKLKQKVPIDERVMPICLPSKDYAEVGRIGYVSGWGRNSNFNFTELLKYVMLPVADQDKCVQHYEGSTVPEKKSPKSPVGVQPILNEHTFCAGMSKFQEDTCYGDAGSAFAVHDQDEDTWYAAGILSFDKSCTVAEYGVYVKVPSVLAWVQETIAGN
What is the function of this protein?
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine.  Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage.  Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response.  Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
What are the official names of this protein?
Haptoglobin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: Y942_TREPA
Sequence: MDGARVSDEEVARRVATLKRLKALLQEQREKFAQYLVVLQQQQVAIEAQDAETVLRHVELEEALLGDVQRVQKALAPMEQLCLQQASGVQELAQLRCDLSRVQEQVYAQNEKNRALLRAQVSDLRQQLDEFRAARGLVSYEDGEDSGTVIDLSL
What are the official names of this protein?
Uncharacterized protein TP_0942.
Protein: THII_LYSSC
Sequence: MIWKEILIRYGELSTKGRNKMDFIRRLRENIRHAFADLGHLHIRTERDRMFIAIENDAQMQTLVTGLPKIFGIQSFSPVAACEKDMESMKQLAITIMETFKDQPYTFKVEVKRTDKTFPLESHAIQREIGGYVLPQFNNLSVKVKQPDIELRVEVRHDATYMMAQVIPGAGGMPVGSNGKSLLMLSGGIDSPVAGYLMMKRGVRLEAIHFFSPPYTSQNSLEKVKVLANELTKFGANIRLHVIPFTEIQVLIKEKVPSNVSMTTTRRMMLKVADQVREEIGALAIVTGESLGQVASQTLESLTAINAVTNTPILRPLISSDKLEIIELAEQIGTYETSIQPFEDCCTIFTPASPKTKPKLEKVEHYESFSDFDELIARAVKNREVYIFPKKEEEQQQDKFADLL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFCB6_MACFA
Sequence: FLETDNEGNGILRRRDIKNALYGFDIPLTPREFEKLWASYDTEGKGHITYQEFLQKLGVNYSPAVHRPCAEDYFNFMGHFTKPQQLQEEMKELQQSTEKAVAARDKLVDCYQDISKAFTKIDKSKTNYISICKMQKVLEECGCSLTEGELTNLLNSWGVSRHDNSINYLDFLRAVENSKSTGAQPKEKEESMPINFATLNPQEVVRKIQEVVESSQLALSTAFSALDKEDTGFVKSTEFGQVLKDFCHKLTDNQYHYFLRKLRIHLTPYINWKYFLQNFSCFLEETAEEWAEKMPKGPPPTSPKAMASRDILARLHKAVTSHYHAITQEFENFDTMKTNTISREEFRAVCNRNVQILTDEQFDRLWNEMPVNAKGRLKYPDFLSRFSSERAATPTATGDSAAAQRGSSVPDVSEGIRSALSLPNQELRPGSKPQSHPCTAASTTAIPGTPPLQNCDPIESRLRKRIQGCWRQLLKECKEKDVARQGDISASEFLALVEKFNLDISKEECQQLIIKYDLKNNGKFAYCDFIQSCVLLLKAKESSLMQRMKIQNAHKMKDSGAETSSFYSALLRIQPKIVHCWRPMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEYYDKTLSSNISYNDFLRAFLQ
What is the function of this protein?
Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.  Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 6, DJ-1-binding protein, DJBP.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, cilium axoneme.
Protein: RS8_ECO27
Sequence: MSMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLKEEGFIEDFKVEGDTKPELELTLKYFQGKAVVESIQRVSRPGLRIYKRKDELPKVMAGLGIAVVSTSKGVMTDRAARQAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.