PharMolix/UniProtQA huggingface dataset:
Protein: RL17_PORGI
Sequence: MRHNKKFNHLGRKAAHRKAMLSNMAASLILHKRIFTTVAKAKALRIYVEPLLTKTKEDTTHSRRIAFSYLQNKYALKELFGDVAAKIADRPGGYTRILKTGYRLGDNAAMCFIELVDYNENMLGEAAKKATKTRRSRKRKSADVVVEAAPAEETPKAAEE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RS11_RICPU
Sequence: MNQTVKVKKKKKTITLGVVHIRASFNNTIVTFTDIQGNTISSASAGGNGFKGARKATPYAAQVTIDRASEKAKEYGLKTISIRIGGPGAQRESAMRALFGQNFVVTSILDVSSIAHNGVRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: CHM4A_HUMAN
Sequence: MSGLGRLFGKGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTKNKRAALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISRPMGFGDDVDEDELLEELEELEQEELAQELLNVGDKEEEPSVKLPSVPSTHLPAGPAPKVDEDEEALKQLAEWVS
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.  ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.  The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).  ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.  When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding.  Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.  CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
What are the official names of this protein?
Charged multivesicular body protein 4a, Chromatin-modifying protein 4a, CHMP4a, SNF7 homolog associated with Alix-2, SNF7-1, hSnf-1, Vacuolar protein sorting-associated protein 32-1, Vps32-1, hVps32-1.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane. Late endosome membrane; Peripheral membrane protein. Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Protein: TATA_SHEB8
Sequence: MGGISIWQLLIVALIVVLLFGTKKLRSLGGDLGGAVKGFKNAMSSEEDKKALEDTEAAKTAQTTQQATEKKPESNKEQA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: FDM3_ARATH
Sequence: MNNKLSDFEKNLYKKLKSGKLEVKVSYRTFLCPYCPDNKKKVGLYVDILQHASGVGNSQSKKRSLTEKASHRALAKYLIKDLAHYATSTISKRLKARTSFIPAETGDAPIIYDDAQFEKLVWPWKGVLVNIPTTSTEDGRSCTGESGPKLKDELIRRGFNPIRVRTVWDRFGHSGTGIVEFNRDWNGLQDALVFKKAYEGDGHGKKDWLCGATDSSLYAWLANADDYYRANILGENLRKMGDLKSIYRFAEEEARKDQKLLQRLNFMVENKQYRLKKLQIKYSQDSVKLKYETEEKEKILRAYSEDLTGRQQKSTDHFNRIFADHEKQKVQLESQIKELEIRKLELAKREAENETQRKIVAKELEQNAAINSYVQLSALEQQKTREKAQRLAVDHKMQKEKLHKRIAALERQLDQKQELELEVQQLKSQLSVMRLVELDSGSEIVNKVETFLRDLSETEGELAHLNQFNQDLVVQERKSNDELQEARRALISNLRDMGLHIGVKRMGELDTKPFMKAMRIKYCQEDLEDWAVEVIQLWEEYLKDPDWHPFKRIKLETAETIVEVIDEDDEKLRTLKNELGDDAYQAVANALLEINEYNPSGRYISSELWNFREDRKATLEEGVNSLLEQWNQAKHLKS
What is the function of this protein?
Acts in association with FDM4 and FDM5 for RNA-directed DNA methylation (RdDM).
What are the official names of this protein?
Factor of DNA methylation 3.
Protein: VSN1_NEIMC
Sequence: MDRLTPEQRKKCMQSNKSKGTKPELALAKAMWALGLRYRKNSGSIFGKPDFSFKKYKVAVFVDGEFWHGKDWEQRKAEIKGNREFWIAKIERNIRRDMEVTGRLKVEGWAVLRFWSNDVVKNTTCCAEKVRQAVRDKQGLSKFQTREK
What is the function of this protein?
May nick NmeDI sequences that contain T/G mispairs resulting from m5C-deamination.  If unrepaired, these mismatches can lead to C-to-T transition mutations.  The very short patch (VSP) repair process counteracts the mutagenic process by repairing the mismatches in favor of the G-containing strand.  This enzyme is an endonuclease that nicks double-stranded DNA within the sequence RTCGGB next to the thymidine residue that is mismatched to 2'-deoxyguanosine.  The incision is mismatch-dependent and strand-specific.
What are the official names of this protein?
Type II nicking enzyme V.NmeDIP, V.NmeDIP, NmeDIP very short patch repair endonuclease.
What is the protein family that this protein belongs to?
Belongs to the Vsr family.
Protein: FTSK_HAEIN
Sequence: MEAVQLDKNQEPNYKGYSGSLIHPAFQQQTTKREKPSTPLPSLDLLLKYPPNEQRITPDEIMETSQRIEQQLRNFNVKASVKDVLVGPVVTRYELELQPGVKASKVTSIDTDLARALMFRSIRVAEVIPGKPYIGIETPNLHRQMVPLRDVLDSNEFRDSKATLPIALGKDISGKPVIVDLAKMPHLLVAGSTGSGKSVGVNTMILSLLYRVQPEDVKFIMIDPKVVELSVYNDIPHLLTPVVTDMKKAANALRWCVDEMERRYQLLSALRVRNIEGFNEKIDEYEAMGMPVPNPIWRLGDTMDAMPPALKKLSYIVVIVDEFADLMMVAGKQIEELIARLAQKARAIGIHLILATQRPSVDVITGLIKANIPSRIAFTVASKIDSRTILDQGGAEALLGRGDMLYSGQGSSDLIRVHGAYMSDDEVINIADDWRARGKPDYIDGILESADDEESSEKGISSGGELDPLFDEVMDFVINTGTTSVSSIQRKFSVGFNRAARIMDQMEEQGIVSPMQNGKREILSHRPEY
What is the function of this protein?
May function as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination.  FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation.  FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
Protein: SYGA_CUPTR
Sequence: MLTFQQMILTLQAYWDRQGCALLQPIDLEVGAGTSHVHTFLRAIGPEPWRAAYVQPSRRPKDGRYGENPNRLQHYYQYQVVLKPAPENILVLYLGSLEALGLDLKQNDIRFVEDDWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGIDCKPITGEITYGIERLAMYLQKVENVYDLVWTEWVENGETRRLTYGDVYHQNEVEQSTYNFEHSNTEILFRHFAEHEGEAKRLMGNGDGADAAAETGTRLALPAYEQVLKAAHTFNLLDARGAISVTERAAYIGRIRNLSRQVAQAYYDSREALGFPMCGQRDGARA
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_BACCQ
Sequence: MTIKRKKVSVIGAGFTGATTAFLLAQKELADVVLVDIPQLENPTKGKALDMLEASPVQGFDANIIGTSDYADTADSDVVVITAGIARKPGMSRDDLVATNSKIMKSITRDIAKHSPNAIIVVLTNPVDAMTYSVFKEAGFPKERVIGQSGVLDTARFRTFIAQELNLSVKDITGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERLEAIVERTRKGGGEIVGLLGNGSAYYAPAASLVEMTEAILKDQRRVLPAIAYLEGEYGYSDLYLGVPVILGGNGIEKIIELELLADEKEALDRSVESVRNVMKVLV
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: PTH_FRATF
Sequence: MPKIKMIVGLGNIGKEYQDTRHNVGEWFIAKIAQDNNQSFSSNTKLNCNLAKVSIDYNNVVLVFPTTYMNNSGLAVSKVANFYKIAPAEILVAHDELDIDSGEIRLKKGGGHGGHNGLRSINQHLGTNDYLRLRIGIGHPGHKSKVANYVLSNPSIAQKKDIDSAIDNGICFLDDIINYKLEPVMQKLHTK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AI2B_DICDI
Sequence: MRIQIEKDQLGWVAGLLDSCGNIMFSKTHVSGNIEIKLKLTDYECLENMKTKYGGAVKVSRTGTRYRLNHSEGLKKLLEDINGQIRIPVRVKKVKEVCEKNNIEIKYPDKELSLDTAWLSGFFDGVGSIVINQTTLENKKQLVLTFNQKNNQILIKIQRIVGGNFYINTNTQSGKYKYALYFTSKEEILQLYEYFKKYPSRAYKNKRIGLIPQYYELQTLMTSIHDNQLQETLWKKFMIQWDYKEIDEIQSGEILKQKGVIR
What is the function of this protein?
Mitochondrial DNA endonuclease involved in intron homing.
What are the official names of this protein?
Intron-encoded DNA endonuclease ai2b.
What is the protein family that this protein belongs to?
Belongs to the LAGLIDADG endonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL35_AERS4
Sequence: MPKMKTNRGAAKRFKKTGSGRFKCKHNHLRHILTKKSSKRKRKLGPKFMVSAADHKRVVACLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: NU1M_LATCH
Sequence: MTKIITHLLNPLAVIIPILLAVAFLTLIERKVLGYMQLRKGPNIVGPYGLLQPLADGLKLFIKEPVRPSTSSPLLFITTPMLALTMALTLWLPLPLPHPMTNLNLGMLFILAISSLTVYSILGSGWASNLKYALIGALRAVAQTISYEVSLGLILLAMIIFAGGFTLTTFNTSQETIWLLTPGWPLAAMWYISTLAETNRAPFDLTEGESELVSGFNVEYAGGPFALFFLAEYANILLMNTLSTILFMGAMHNPITPELTSINLMIKASALSMLFLWVRASYPRFRYDQLMHLVWKNFLPITLAMILWHTSLPIFTGSLPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CBPM_PSEE4
Sequence: MSSTLIVQLDMRTLCQEADVSADWVIEIVEHGIVEPSGRTPEEWVFDDRAPVTLKRAVKLHQELELEWEGVALALELLEEVQQLRSENSMLKQRLGRFTQM
What is the function of this protein?
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA.  Together with CbpA, modulates the activity of the DnaK chaperone system.  Does not inhibit the co-chaperone activity of DnaJ.
What are the official names of this protein?
Chaperone modulatory protein CbpM.
What is the protein family that this protein belongs to?
Belongs to the CbpM family.
Protein: GGT2_ARATH
Sequence: MSLKALDYESLNENVKNCQYAVRGELYLRASELQKEGKKIIFTNVGNPHALGQKPLTFPRQVVSLCQAPFLLDDPNVGMIFPADAIARAKHYLSLTSGGLGAYSDSRGLPGVRKEVAEFIERRDGYPSDPELIFLTDGASKGVMQILNCVIRGQKDGILVPVPQYPLYSATISLLGGTLVPYYLEESENWGLDVNNLRQSVAQARSQGITVRAMVIINPGNPTGQCLSEANIREILRFCCDERLVLLGDEVYQQNIYQDERPFISSKKVLMDMGAPISKEVQLISFHTVSKGYWGECGQRGGYFEMTNIPPRTVEEIYKVASIALSPNVSAQIFMGLMVSPPKPGDISYDQFVRESKGILESLRRRARMMTDGFNSCKNVVCNFTEGAMYSFPQIKLPSKAIQAAKQAGKVPDVFYCLKLLEATGISTVPGSGFGQKEGVFHLRTTILPAEEEMPEIMDSFKKFNDEFMSQYADNFGYSRM
What is the function of this protein?
Catalyzes the Glu:glyoxylate aminotransferase (GGT), Ala:glyoxylate aminotransferase (AGT), Ala:2-oxoglutarate aminotransferase (AKT) and Glu:pyruvate aminotransferase (GPT) reactions in peroxisomes.
What are the official names of this protein?
Glutamate--glyoxylate aminotransferase 2, AtGGT2, Alanine aminotransferase GGT2, Alanine--glyoxylate aminotransferase GGT2, Alanine-2-oxoglutarate aminotransferase 2.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
What are the subcellular locations of this protein?
Peroxisome.
Protein: ECPR_SHIBS
Sequence: MTWQSDYSRDYEVKNHMECQNRSDKYIWSPHDAYFYKGLSELIVDIDRLIYLSLEKIRKDFVFINLNTDSLSEFINRDNEWLSAVKGKQVVLIAARKSEALANYWYYNSNIRGVVYAGLSRDIRKELAYVINGRFLRKDIKKDKITDREMEIIRMTAQGMQPKSIARIENCSVKTVYTHRRNAEAKLYSKIYKLVQ
What is the function of this protein?
Part of the ecpRABCDE operon, which encodes the E. coli common pilus (ECP).  ECP plays a dual role in early-stage biofilm development and host cell recognition.  Positively regulates the expression of the ecp operon (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator EcpR.
What is the protein family that this protein belongs to?
Belongs to the EcpR/MatA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOTZ_DROPE
Sequence: MSRLIHLSFVLALLACLTGTISANPIDDDRDRLNQLLSNPEPADDAELLRNTQEAIALYKKHARRTLPGHQVELDLDRDIRAFETENLTVDGLPIQGGVWDLIKKGADKVPDEVKDQAKELAKTTAKALFNKLTEYLKKKISGEDAAKKDT
What is the function of this protein?
A humoral factor that may play a role in stress tolerance.
What are the official names of this protein?
Protein Turandot Z.
What is the protein family that this protein belongs to?
Belongs to the Turandot family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGE_PROMH
Sequence: MNIKLPTFIELYRQLIATPSISATDAKTDQSNEALINLLANWLETLGFSIEIQPVPETRGKFNLLATLGSGTGGLLLCGHTDTVPFDEGRWTQDPFTLTEKEGKLYGLGTADMKGFFAFIIDALRDIDTSQLTHPLYILATADEETSMAGARYFAANTAIRPDFAIIGEPTSLQPIRAHKGHLSNAIRITGQSGHSSDPEKGVNAIELMHESITHLSTLRDRLKTRYNNPAFVIPYPTMNFGYINGGDAANRICACCELHMDIRPLPGLTLQDLDDLLHETLAPVKARWPGRLSVEALHEPIPGYECPTDHKMVAVIEKLLGEKAQTVNYCTEAPFIQALCPTLVLGPGSIEQAHQPDEFIDMAFIEPTRELMGQLIENFCLAEKAK
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHJ_SYNS9
Sequence: MSDSAPTNPTPTNPAPEESASAVATLEPGPVSQWLNTQGFDHDVLDPDHVGVEQIGVESAVLPIIVAAIKSHGFDYLQCQGGYDEGPGERLVCFYHFIAMAEQVEAMTAGRPHELREVRLKVFLSREGTPSLPSIYGLFRGADWQERETFDMYGIEFEGHPHPKRLLMPEDWKGWPLRKDYVQPDFYEMQDAF
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J, NDH-1 subunit J, NDH-J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: 3SA5_NAJMO
Sequence: LKCKKLIPLFSKTCPEGKNLCYKMTMRLAPKVPVKRGCIDVCPKSSFLVKYECCDTDRCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes (PubMed:8182052).  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
What are the official names of this protein?
Cytotoxin 5, CTX M5, CTX V.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: HIUH_SALTY
Sequence: MKRYILATVIASLVAAPAMALAAGNNILSVHILDQQTGKPAPGVEVVLEQKKDNGWTQLNTGHTDQDGRIKALWPEKAAAPGDYRVIFKTGQYFESKKLDTFFPEIPVEFHISKTNEHYHVPLLLSQYGYSTYRGS
What is the function of this protein?
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
What are the official names of this protein?
5-hydroxyisourate hydrolase, HIU hydrolase, HIUHase, Transthyretin-like protein, TLP.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: FDX2_XENLA
Sequence: MAVFLLKRGVWASLMIGGFGPRAVLFSKLGQNHARLSQATPEKLETSNEEEGSSSAQITAGVESDAENQRAELSEETVEVVFLDRSGQRIPVKGKVGESVLCLAHRYNIELEGACESSLACSTCHVYVNTEYFHKLPEPDEREDDMLDMAPLLQENSRLGCQIILTKQLNGAEFTLPKITRNFYVDGHVPKPH
What is the function of this protein?
Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity).  The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis.  This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner.  Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly.  Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).
What are the official names of this protein?
Ferredoxin-2, mitochondrial, Adrenodoxin-like protein, Ferredoxin-1-like protein.
What is the protein family that this protein belongs to?
Belongs to the adrenodoxin/putidaredoxin family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SH24A_RAT
Sequence: MLRQILSEMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREAAMERKESLPVKSRPKKENGKSVHWKLGADKQVWVWVMGEHHLDKPYDVLCDEILAEREHLRAAKDAELRKAQSLQFTNSLKVKSLNCDLQAVKKTEPQNVTRKAAAEEATDQGPRAIPTKKDDKAQTKDLTKKKDSEELKQTEDEKTKQIYKNWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPKRPPLPPKPQFLQPLGSPPKSLGNQGVIRTKTSSTQEDIIRWFKEEQLPFRAGYQKNSDTIAPWFHGILTLKKANELLSTGMPGSFLIRVSEKIKGYALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLFPCGQQDKPPDYLELFQ
What is the function of this protein?
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation.  May play a role in T-cell development and function (By similarity).
What are the official names of this protein?
SH2 domain-containing protein 4A.
What are the subcellular locations of this protein?
Cytoplasm. Note=Located at podocyte foot processes.
Protein: TGFR1_PIG
Sequence: MEVAAGAPRSRLLLFVLAATATLAPEATAFQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTVGPFPGKPPSGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
What is the function of this protein?
Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.  Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.  The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2.  Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4.  The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes.  This constitutes the canonical SMAD-dependent TGF-beta signaling cascade.  Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.  For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis.  Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity).
What are the official names of this protein?
TGF-beta receptor type-1, TGFR-1, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Membrane raft. Cell surface.
Protein: LLDD_SALPA
Sequence: MIISAASDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNETLSMPVALAPVGLCGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTIQRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWIREFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKAGVANLLDLVEKEMKVAMTLTGAKSISEISGDSLVQELGKSLPAALAPMSKGDAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y1120_THEKO
Sequence: MIINETKGKAWHGKVKLADTFLKRFRGLMLVKNVNHALVFVLPAETRANASIHMFFMLSDIDVIWLDSSRRVVDFKTAKKWRLYTPKKAAQYIIEGPVGLIRTLEVEEGDLISWTPTEEREKAVPVKSLIPGKINLNGSKNSIAMVESVKEVKANEV
What are the official names of this protein?
UPF0127 protein TK1120.
What is the protein family that this protein belongs to?
Belongs to the UPF0127 family.