PharMolix/UniProtQA huggingface dataset:
Protein: PEX9_YEAST
Sequence: MNEVTCSITGDNPIHKINNGLGLKWNNLGKFSDFQTNDSAARDARTIDYIFTNCQTGSSIGKIDFRAALPADKSQHSGVSEKEFSRLENQWSKEFSCFPKNKNADVTKPSRNKHEKRSANLHNRYFAQYYSTAYQQNRIYPCRISYNEHSSVSNGWEFQFKSIENQLLNELKIENNVEEKTVGYEYVAEYEETIDFMHMLSSVPQTYQFLKSNIYITERDPYKIGCVLMDNGSNLNEVVMAFEAAISQDPSHINAWLKLGIVNFENESESNGELALRNCLNLDPNNTIALENLAIHHINQQNESESLKLFHKWILSKFSKVFQPSAGENKDSINKIPKKAHLAHILESLLNMGIEKKDQYDIYSVLSILYYSDQKIKQSQKCLEFLLLEKPNNGTIWNRYGAILANTKSYHSAINAYNKCKQLRPNFTRVRYNLAIAYMNKGDYVKASKMLIEVILLRSKGYEHNKAKMQNKFMQNLKNALIASKNFDSLDLINGSHNTESLISTLKAIYNKMD
What is the function of this protein?
Peroxisomal import receptor that mediates the peroxisomal import of both malate synthases MLS1 and MLS2 in oleate-grown cells (PubMed:27678487, PubMed:27663510).  Recognizes the C-terminal peroxisomal targeting signal PTS1 sequence SKL of MLS1 and MLS2, probably via its TPR domains (PubMed:27678487).  Interacts with the PTS1-receptor docking protein PEX14 but not with peroxins PEX1, PEX3 through to PEX8, PEX10, PEX11, PEX12, PEX13, PEX15, PEX17, PEX18, PEX19 and PEX21 (PubMed:27678487).
What are the official names of this protein?
Peroxisomal targeting signal receptor 9, PTS1 receptor 9, PTS1R 9, Peroxin-9.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal targeting signal receptor family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Peripheral membrane protein.
Protein: CDP_ACRMI
Sequence: MFLFSLTVLSALVLITESIPSVATDFPFFEITKKFDDIETYNNDYGILKFQEQEPMENLTCASCEAPSERECTLNQTAVVCDQDPNIACLTFEAFNNFTMTTTFRRGCFLSGILCENACRSFNASQDGNLTSCVQDCCNSSLCNAGSLPTEVTTEASTTAQETTATSTTTKQSTGASTTAEPSTTAAPSTTTKQTTVASTTATTTKPTTAPQTRATTLPTTAPTTAPAPIACGGVLRGRGTFTSPGFPGNYPNNVRCEWRVFLPRRQAIVFRIVSLDLADPGDSLEFFDSGRVIRTFRGLSRRKRSPSHRQTTNEKVLGEGEDGYYDDQEYVDYYYYDGRRKREPYFYQRRKKRRQQDRIVIQGRNQVAGAIFQSDAAGNAAGFSTQFVQGAADSESEASASSESSDED
What are the official names of this protein?
CUB domain-containing protein.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPB_FUSV7
Sequence: MSSALSPEGDRRYSDDSLSSVSTTSLVFERIQEKTEMDADNDKEKDPRALDDEDPLRDEDDLETGPFLGPGASLHREPMDRGLRRILIIVAVVFIGGWLAGLGIFIASGSYHHESDTEHDPDANSRGSGKSLSMDQLFDGTWSPKYHSISWIAGPKGEDGLLLEVGASNKPYIVVEDIRSDKNVATRDDAEPKASNSRTLMEHPYFEYDGKQYSPSWSEPSPDLTKVLLGVDRKKNWRHSFSAIYFVLDVKTQEAEPLVPDQVDARIQLASWSPKSDAVSFTRENNLYIRRLTGDKDVTQITKDGGPEYFYGIPDWVYEEEVFSGRSATWWSDDGKYLAFLRTNETGVPEYPVQFFIERPSGTTPEDGEEAYPEVEQIKYPKAGAHNPVVDLQFYDIGKKDTFSVEIDGAFADDDRIINNLLWAGDKAIVKQTNRVSDVLKVVLVDVPSRKGKTINTININEIDGGWFEISHKMTYIPADPKNGREHDGYVDSVIHEGYDHLAYFTPLDNSEPIMLTKGNWEVDDAPSAVDLANNLVYFIAAKESSIQRHVYSVKLDGSDLQALTDPKTEAYYDASFSKGAGFVFLSYRGPKVPTQKVISTPVSASSYERIIEDNAELADRARRHELPILKYGTLDLDTGVKVNYVERRPPHFDAKKQYPVLFHQYSGPGSQSVTKRFAVDFQAYVAAALGYLVITVDPRGTGFLGRKHRVTVRSKLGVHEAHDHIAAAASFASRPYVDAERLAIWGWSYGGFTTLKTLEQDAGRTFSYGMAVAPVTDWRFYDSIYTERYMRTPQDNPDGYDLSKVANATALGENKRFLLMHGVADDNVHFQNSLTLLDDLDLAGVENYDVHVFPDSDHSIYFHNGNRIVYDKLRNWLINAFNGEWLKVSNPQPQKDPVEKEKRHMVPQALV
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: ACEK_YERPS
Sequence: MVAKLEQLIAQTILQGFDAQYGRFLEVTAGAQHRFEQADWHAVQQAMKKRIHLYDHHVGLVVEQLKYITDQRHFDVEFLARVKEIYTGLLPDYPRFEIAESFFNSVYCRLFKHRDLTPDKLFVFSSQPERRFREIPRPLARDFIPKGDLSGMLQMVLNDLSLRLPWENLSRDIDYIVMAIRQAFTDEQLASAHFQIANELFYRNKAAWLVGKLRLNGDIYPFLLPIHHNESGELFIDTCLTSKAEASIVFGFARSYFMVYVPLPAAMVEWLREILPGKSTAELYTAIGCQKHGKTESYREYLAFIHQSSEQFIIAPGVKGMVMLVFTLPSFDRVFKVIKDQFAPQKEVTQARVLECYQLVKEHDRVGRMADTQEYENFVIDKHRISPELLAELQHEVPEKLEDLGDKIVIKHLYMERRMTPLNLYMEQADDQQLKDAIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRYPEDEMASEPWYSVSPNDVFPEEFRHFLCSDRKVRHFFEEMHGDLFQASYWRGLQQRIRDGHVEDVFAYRRKQRFSQRALN
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAST1_MOUSE
Sequence: MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFARAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVRLEEQDSGGSNTPEQDDTSEGRSSTSKAKKPPGESDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTDAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVSASGASKRDPSAKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARRRFSALLEPSRFTAPQEDEDEARLRRPPRPSSDPPSSLDTRVPKEAVQGEGTSTPGEPEATERSHPGDLGPPSKDGDPSGPRATNDLVLRRARHQQLSGDLAVEKRPSRTGGKVIKSASATALSVMIPAVDPHGGSPLASPMSPRSLSSNPSSRDSSPSRDYSPAVSGLRSPITIQRSGKKYGFTLRAIRVYMGDSDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRPSAKDGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAGNIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPLLKRVQSAEKLGASLGADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPIEGPGATRQVAVRRLGRQESPLSLGADPLLPDGVQRPMASSKEDSAGGTEACTPPRATTPGSRTLERDSGCTRHQSVQTEDGPGGVARALAKAALSPVQEHETGRRSSSGEAGTPPVPIVVEPARPGVKTQAPQPLGTDSKGLKEPVAQMPLMPDAPRGRERWVLEEVEERTTLSGLRSKPASPKLSPDPQTPTLVPTKNVPRSAAPSVPPASLMVPGTKPEAGLNSRCPAEAVTPAGLTKTGAPSPASLGP
What is the function of this protein?
Microtubule-associated protein essential for correct brain development (PubMed:30449657).  Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins.  Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins.
What are the official names of this protein?
Microtubule-associated serine/threonine-protein kinase 1, Syntrophin-associated serine/threonine-protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Note=Also localized in the soma of neurons (PubMed:30449657). Observed as punctate clusters in the processes of interneurons and along the cell body periphery. Colocalizes with syntrophins at the cell membrane.
Protein: SYDND_PROM2
Sequence: MRNKICKELNNTDIGKLVNLCGWVDRRRDHGGVIFIDLRDHSGFLQITINPDDGADLFKQAETLRNETVIMVSGIINERPKDSINTNLSTGELELKVKDLQVLNQIKNNLPFPVSIHDYENTKEELRLKYRYLDLRRGKLLENLKTRHKIIKVSREFLDNFGFTEVETPLLTKSTPEGARDFLVPARLSNGEFFALPQSPQLFKQLLMVGGLDKYYQIAKCFRDEDLRADRQPEFTQLDIEMSFVSEEEIISFNESLIKKIWKEVLNINFNNAFPRMSWQAAMDNYGTDRPDTRYEMLLKDLGGVLGDIGFNIFTKAIKAGGYIKSITVKGGNSSISNVRIKPGGDIFQVAQDAGAGGLAFIRVKGDELETIGAIKNNLSEEHIADILKITEAKDGDLILLGAGDKQIVNQSLDRVRQYIAKDLNLIDKSKWNFLWVTDFPMFERNEDENRYEALHHPFCSPKNIKSKDSDKMQKEIENSIANAYDLVLNGMELGGGSLRIHEANLQREVLKTVGLTDKEIDEKFGFLIEALEMGAPPHGGIAFGLDRITMLLIGADSIRETIAFPKNQQAKCLLTNAPSNVSESQLKELDIEITIDE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRA_SHISS
Sequence: MKSNRQARHILGLDHKISNQRKIVTEGDKSSVVNNPTGRKRPAEK
What is the function of this protein?
Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein.
What are the official names of this protein?
Stationary-phase-induced ribosome-associated protein, SRA, 30S ribosomal protein S22.
What is the protein family that this protein belongs to?
Belongs to the SRA family.
Protein: SELD1_PEPAC
Sequence: MDIKKLKLHHRLETNKLKTNKHYEEEVKLTQMVRAAGUAAKLGPEYLAKALEIIPQVFNKDLLVGYEHSDDAAVYRINSETALILTLDFFTPVVDDPYLFGLISATNSLSDVYAMGGKPLVAMNIVCFPACKDVGILAQILKGGFDKVQESGAILVGGHSVDDNEPKYGLSVCGIVHPGRVLSNSAAKVGDVLVLTKPLGTGIINTGIKAGIVGQQTVDEVVKIMTHLNKYAALAFDDIRVNSATDVTGFGFLGHTMEMARGSDVTIEITVAQIPFIAETEELAKSGIIPAGAYRNRDFVKNDVRMEGIADHISDILYDPQTAGGLLVSVPENDAKALVAKMLAYGSLDARIVGRVIPKADKYVIVR
What is the function of this protein?
Synthesizes selenophosphate from selenide and ATP.
What are the official names of this protein?
Selenide, water dikinase 1, Selenium donor protein 1, Selenophosphate synthase 1.
What is the protein family that this protein belongs to?
Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Protein: HP251_BOVIN
Sequence: MPGGRRRVGSMNIAGFWILAQFVLLLVANVKSSADSELCGPRGARGPPGLSGLPGPPGYTGPIGMPGLTGRPGLPGLVEKCPPLPQSAFSVKLSGPFPGPSQPIVFQEVLYNHQGHFDPATGVFNCSVPGVYHFGFDIELFQSAVKVGLMRNGIQIRDKRAEAGDSHEQASGSSVLELEKGDRVWLESKLDREESEKGTTHAVFYGFLLNGN
What are the official names of this protein?
Protein HP-25 homolog 1.
Protein: RL16_SYNR3
Sequence: MLSPRRVKFRKQQRGRMRGIATRGNTIAFGTFALQAQECGWITSRQIEASRRAMTRYTKRGGKIWIRIFPDKPVTMRAAETRMGSGKGNPEFWVAVIKPGRILFEIGGPEITEELAKEAMRLAQYKLPVKTKFLVKEEQEAAVEATAQTAAVES
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: URK_LIGS1
Sequence: MANRENKPVIIGVTGGSGSGKTTVSRAIFEQLHGHSLLMLQEDSYYNDQSDMPFEERIKTNYDHPNAFDTELLVKQLKDLLDWKTIEKPIYDYTEHTRSSEVEKVEPKEVIILEGILVLNDPALRDLMDIKIFVDTDDDIRIIRRIQRDIEERGRSLQSVIDQYKSTVKPMYHQFIEPTKRYADIIVPEGGENQVAIDLLVTKVRDILRKREK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BLM_CAEEL
Sequence: MIKNREIEVAPPRRTIQFGGYTFVEPDLNFKAPIFSCCGSIRDPSCEEREEEYIDNGHDEEPPVEVNRIQESTSFDEPVSSPPRYRPSENPGPSSSSYEPGHYSFNEYQQFPSRPQKRLVDPPIVDLDEEPPIVDLDDSFDNFHVGSTSEEVVSGDIAPEEEEEEGHDSFDDFESVPAQPPSKNTLASLQKSDSEIALNQQRHDMHGRFRGFLQDDSEEFSDEVGLLGADMNKELYDTLKSKFGFNQFRHRQKQCILSTLMGHDTFVLMPTGAGKSLCYQLPAVILPGVTVVVSPLRSLIEDQKMKMKELGIGCEALTADLGAPAQEKIYAELGSGNPSIKLLYVTPEKISASGRLNSVFFDLHRRGLLARFVIDEAHCVSQWGHDFRPDYTKLSSLREKYANPPVPIIALTATATPKIVTDARDHLKMQNSKLFISSFVRDNLKYDLIPKAARSLINVVEKMKQLYPGKSGIVYCLSRKECETVQMMLTKAGLSAEVYHAGLNDNLRVSVQRSWIANKFDVICATIAFGMGIDKPDVRFVIHYSLPKSIEGYYQETGRAGRDGMPSYCLMLYSYHDSIRLRRMIEEGNTTTGVRSMHLNNVLQVVAYCENVSVCRRKMLVEHFGEVYDEQSCRNSKTPCDICERQRKNAEAIRLFDVSTDALSILKCLPRMQKATLKYISELYRGALIKKSQEQAMRLGHTKLPFYSKGQGMSEQDALRFVRKLVIEGYIHERLYSVPNQAAAVFAYAELTEAGRDLANGKKTAKVYLHIVTCERKRKNAGLIELSNMNIVSEAQALKERHMVKHGDVFTRCLQDLTHLITAVAESSGLSGPYSIVSREGIEQIAALLPRTNSDLLRIDSMTQIKVTKYGRLIMELLATYWKQVDEREEEEMRNQLDKLKSGEIVMGGFATLQSDPGFPSVPYMKPLGGGGGCRGRGKKRAFSGFSSGRATKKPRATAPSARGKTSGRGGAKPATSLKRNMYPATSM
What is the function of this protein?
ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction.  Participates in DNA replication and repair.  Negatively regulates sister chromatid exchange (SCE) (PubMed:27010650).  Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution.  Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction.
What are the official names of this protein?
RecQ-like DNA helicase blm-1, Bloom syndrome protein homolog, High incidence of males protein 6, RecQ helicase homolog.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes on chromosomes during pachytene in meiotic prophase I in oocytes. Co-localizes with rmh-1 at mid-pachytene and late-pachytene in meiotic prophase I (PubMed:27011106). Localization at nuclear foci is dependent on rmh-1 during meiotic recombination (PubMed:27011106).
Protein: LEUD_BACAC
Sequence: MEPFRIHKGTAAVLMNDNIDTDQIIPKQYLKRIERTGFGKFLFDEWRYDNERHENPNFPLNAPDRKGASILITGNNFGCGSSREHAPWALADYGFRVIIAGGFADIFYMNCMKNGMLPIVMDKEMREKLVKTDAREQIEVDLENEVITTSTHRFHFTIEKMWKEKLLNGLDEISITMQYEQEIKEYERRIAAY
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: CSN12_DEBHA
Sequence: MNTPLSDYIQKVCLSVNLEDSQKFRSCITINPGINEGTIRAHFPEPNDFDLHPIPEKFRNVVKSYLKLMKSVYIANSINASFFDLNEMVNNLNRAADTQTNWINQPLINACTELISVYQVRSKNFPEEEEMELSNLENNEYGNSSSSLERLAATINGSFKLSLNDKNLDLSQSKRLDIYFFLGNLIKIYFKLGKLELAKSVEKALKGTRFNLPKLNGAGSSKRYAVTYLYYSALLSLDDADFTTSEEKLVKAMEILSCYKDPKNVKNQTEKILIILLPLKLYNKRLTPSNEIWEKFPKLKFMYKDNLFDAIKNGNLKKFDQALTKYQLILLKNHLYLLFEMMKSLCYLKLVKKTVSIIHSLNSETKSHIVPLSAIQLALEFSTNDSYKESDKFAYNLDAVECILANLISSGKIKGYLSHANRCIVLSKANAFPSLEYK
What are the official names of this protein?
Protein CSN12 homolog.
What is the protein family that this protein belongs to?
Belongs to the CSN12 family.
Protein: PRS51_HUMAN
Sequence: MFQLLIPLLLALKGHAQDNPENVQCGHRPAFPNSSWLPFHERLQVQNGECPWQVSIQMSRKHLCGGSILHWWWVLTAAHCFRRTLLDMAVVNVTVVMGTRTFSNIHSERKQVQKEEERTWDWCWMAQWVTTNGYDQYDDLNMHLEKLRVVQISRKECAKRINQLSRNMICAWNEPGTNGIFKVLTPAQPPPPSRETVGHLWFVLFMEPRDSSKWVSSVGA
What are the official names of this protein?
Serine protease-like protein 51.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CP7A1_RABIT
Sequence: MITIFWIWGICLSVCCCLWLILGLRRRRMGEPPLEKGWIPYLGCALQFGANPLDFLRANQRKYGHVFTCKLMGKYVHFITNSLSYHKVLCHGKYFDWKKFHFTTSAKAFGHRSIDPRDGNTTENINNTFNKTLQGDALISLTDAMMENLQLTLRRPEPKSRAWVTEGMYSFCYRVMFEAGYLTLFGRELTRQDAQRAFILNSLEDFKQFDKVFPALVAGLPIHIFMTAHNAREKLAEGLKHDNLRTRDHISELIRLRMFLNDTLSTFDAMEKAKTHLAILWASQANTIPATFWSLFHMMRSSEALKAATEEVNKALEDADQQINFEGKPIHLNQTQLNDMPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPMTFKYDRYLDENRKTKTTFYSKGLKLKYYYMPFGSGATICPGRLFAIQEIKQFLILMLSYFELEFVDSHVKCPPLDQSRAGLGILPPLNDIEFKYKFKHL
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity).  Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable).  Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (Probable).  7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol (By similarity).  Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity).
What are the official names of this protein?
Cytochrome P450 7A1, 24-hydroxycholesterol 7-alpha-hydroxylase, CYPVII, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Protein: MRAY_GLOC7
Sequence: METKLFSSASLIKPSGTSLLILLTVVLFLLMTLFQWLLTSSLEGIYAVILPVSVSAIACGLLGFGVIPLLRWLKTGQFVREDGPQSHLKKAGTPTMGGIFFIPVAVGVALIGSKFDPQVVAVGIVTLAYMMIGWVDDWQVLRQKSNKGISPKMKLLLQIAVAVLFCLWMLWTGSPNITNLSLPGNLIIPLGWLFWILAIFVLVAESNATNITDGVDGLASGTCAIAFLGLAAIVAPTSVGLMIFCACLSGGCLGFVLHNRNPAKVFMGDTGSLALGGALAAVGLLSGNLWGLFIISGIFFVESLSVIAQVSYYKATKGPDGQGKRLLKMAPLHHHLELSGWSETQIVGVFYLINAGLAILGFISR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDXS_BACP2
Sequence: MSNKGTERVKRGMAEMQKGGVIMDVVNAEQAKIAEEAGAVAVMALERVPADIRAAGGVARMADPRIVEEVQNAVTIPVMAKARIGHIVEARVLEALGVDYIDESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEAVRHMRKVNAQIRKVAAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATPADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYGLIAELSKELGTAMKGIEISNLLPEERMQERGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: RBL1A_HYDMR
Sequence: MAKTYNAGVKEYRETYWMPEYEPKDSDFLACFKVVPQPGVPREEIAAAVAAESSTGTWTTVWTDLLTDLDYYKGRAYRIEDVPGDDSAFYAFIAYPIDLFEEGSIVSVMTSLVGNVFGFKALRSIRLEDIRFPLAYVMTCGGPPHGIQVERDKMDKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVTSQPFMRWRDRFLFCQDAIEKAQDETGERTGHYLNATAGTPEEMYERAEFAKEIGSPIVMHDFLTGGLTANTGLANYCRKNGLLLHIHRAMHGVIDRNPLHGIHFRVLSKVLRLSGGDHLHSGTVVGKLEGDRGSDLGWIDIMRDSFIAEDRSRGIMFDQDFGEMPGVIPVASGGIHVWHMPALVAIFGDDSVLQFGGGTIGHPWGNAVGAAVNLVALEACVQARNEGQEIEKNGKEILTNDGKHSPELKIAMETWKEIKFEFDTVDKLDLSHK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain 1, RuBisCO large subunit 1.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: TUSC_SALPK
Sequence: MKRIAFVFSTAPHGSASGREGLDALLATSALTEALGVFFISDGVFQLLPGQKPDAVLARDYIATFKLFDLYDIDQCWICAASLRERGLENVNFVVNATPLEPVALRRELGNYDVILRF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_ECOHS
Sequence: MPVITLPDGSQRHYDHAVSPMDVALDIGPGLAKACIAGRVNGELVDACDLIENDAQLSIITAKDEDGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVIDNGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHEARETFANRGESYKVSILDENIAHDDKPGLYFHEEYVDMCRGPHVPNMRFCHHFKLMKTAGAYWRGDSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSDYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZFAN3_MOUSE
Sequence: MGDAGSERSKAPSLPPRCPCGFWGSSKTMNLCSKCFADFQKKQPDDDSTPSTSNSQSDLFSEETTSDNNNTSVTTPTLSPSQQSLPTELNVTSPSTEECGPCTDTAHVSLITPTKRSCGADSQSENEASPVKRPRLVENPERPEESGRSKQKSRRRCFQCQTKLELVQQELGSCRCGYVFCMLHRLPEQHDCTFDHMGRGREEAIMKMVKLDRKVGRSCQRIGEGCS
What are the official names of this protein?
AN1-type zinc finger protein 3, Testis-expressed protein 27.
Protein: FIMA1_PORGN
Sequence: MKKTKFFLLGLAALAMTACNKDNEAEPVTEGNATISVVLKTSNSNRAFGVGDDESKVAKLTVMVYNGEQQEAIKSAENATKVEDIKCSAGQRTLVVMANTGAMELVGKTLAEVKALTTELTAENQEAAGLIMTAEPKTIVLKAGKNYIGYSGTGEGNHIENDPLKIKRVHARMAFTEIKVQMSAAYDNIYTFVPEKIYGLIAKKQSNLFGATLVNADANYLTGSLTTFNGAYTPANYANVPWLSRNYVAPAADAPQGFYVLENDYSANGGTIHPTILCVYGKLQKNGADLAGADLAAAQAANWVDAEGKTYYPVLVNFNSNNYTYDSNYTPKNKIERNHKYDIKLTITGPGTNNPENPITESAHLNVQCTVAEWVLVGQNATW
What is the function of this protein?
Structural subunit of the major fimbriae (PubMed:1987052).  These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome.  They play an important role in the invasion of periodontal tissues (PubMed:1987052, PubMed:11748193).  Fimbriae and their constituents are major virulence factors.  FimA proteins from different strains have highly divergent sequences, and this has been used for classification.  The sequence-based classification correlates with pathogenicity.
What are the official names of this protein?
Major fimbrium subunit FimA type-1, FimA1, Fimbrillin, Fimbrilin, Major fimbrial subunit protein type I.
What is the protein family that this protein belongs to?
Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.
What are the subcellular locations of this protein?
Fimbrium. Cell outer membrane. Note=Synthesized as palmitoylated precursor. The lipidated propeptide is removed during processing to the mature protein.