PharMolix/UniProtQA huggingface dataset:
Protein: RL13_FRATO
Sequence: MKTFTAKPSNIKREWLLIDATDKTLGRLATEVAMILRGKNKPEYTPHMDTGDYVVIVNAEKVAVTGNKRKAKTYYHHTGYIGGIKSVSFEKLIATHPERAIEKAVRGMLPRTPLGRTMFKKLKVYAGEAHPHTAQQPKAHNI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: CRCB1_CLOAB
Sequence: MKKYILIGLGGAIGAILRCFIRNTKIPVYKGEFPISTLMINLSGAFILAVILITANEIWSFNEEIRLGIATGFVGAYTTFSTMCKETIILMNKNLYFLAFCYVTVSVVFGLLFAYFGALSARKILSRLLKVRKEDEKAS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRC_AGRVS
Sequence: MRSLTIRRPDDWHLHLRDGAMLEGVIGDTSRHFARAIIMPNLVPPVVTTADAEAYRQRILAAVPKGDRFEPLMTLYLTEQTSPDDVEEGKTTGLITAVKLYPAGATTNSHGGVRDLDKAMPVLERMAKIGLPLCVHGEVTTPEVDIFDREAVFIDTVLDPLRRRLPELKVTMEHVTTSDGIDYILSADSNLAGSITTHHLIINRNAILVGGIRPHYYCLPVAKRESHRLALRRAATSGDSRFFLGTDSAPHVDPLKECGCGCAGIYTSINTMSCLAHVFEEDEALERLEAFVSLNGPAWYGLQPNDEMITLVRRDAPVAFPAKIETGAGPVTVFDPMFPIHWDVEAAIQA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: AAKB1_PONAB
Sequence: MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQRDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
What is the function of this protein?
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.  In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.  AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.  Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.  Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).
What are the official names of this protein?
5'-AMP-activated protein kinase subunit beta-1, AMPK subunit beta-1, AMPKb.
What is the protein family that this protein belongs to?
Belongs to the 5'-AMP-activated protein kinase beta subunit family.
Protein: TPC1_YEAS7
Sequence: MFKEEDSLRKGQNVAAWKTLLAGAVSGLLARSITAPMDTIKIRLQLTPANGLKPFGSQVMEVARSMIKNEGIRAFWKGNIPGSLLYVTYGSAQFSSYSLFNRYLTPFGLEARLHSLVVGAFAGITSSIVSYPFDVLRTRLVANNQMHSMSITREVRDIWKLEGLPGFFKGSIASMTTITLTASIMFGTYETIRIYCDENEKTTAAHKKWELATLNHSAGTIGGVIAKIITFPLETIRRRMQFMNSKHLEKFSRHSSVYGSYKGYGFARIGLQILKQEGVSSLYRGILVALSKTIPTTFVSFWGYETAIHYLRMY
What is the function of this protein?
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
What are the official names of this protein?
Mitochondrial thiamine pyrophosphate carrier 1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DUT_RICAE
Sequence: MTITQVKIKKLENFSGSLPEYATEHSAGMDLIAANEQPITIKAAAIQLIPTGIAIALPDSFEAQIRPRSGLAVKHGITVANSPGTIDADYRGEIKVILINLGKEDFIIEKGMRIAQMIIAKYERILWEESSSLMETMRGSGGFGSTGV
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: Y1766_ALKOO
Sequence: MEDHYGYMSIKNMPMSERPREKLLSFGSQSLSNAELLAIILSTGTKDRTAIDLARSILNTSTEGLRGLKDCTIEELSQVKGVGLAKASQIIAAVELGKRISLTTKVNNYKIKGPDDVSNLLMEEMRYLNKEIFNILLLTTKHDIIAIENISVGSLNASIVHPREVFNRAIKRSSSAIILAHNHPSGDPNPSGEDINITKRLIEAGNIIGISVLDHIIIGDGVYFSMKEHKLI
What are the official names of this protein?
UPF0758 protein Clos_1766.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: FPUD_BACAN
Sequence: MQKALETKRLTLSYGETIIIDELNLEIPKGEITIFIGSNGCGKSTLLRSLARLLKPTTGDILLDNQAIQSMQTKQIARQMAILPQGPQAPEGLTVLQLVKQGRYPYQTWLKQWSEKDEEMVQNALAATGMTEFAERDVHALSGGQRQRAWIAMTLAQDTDIILLDEPTTYLDMTHQIEVLDLLFELNETEQRTIVMVLHDLNLACRYADNIVAIQDKQIYAQGKPEEVVDEKLVRDVFRMECQISTDPLFGTPLCIPHGKGRRVRKEVAHAMR
What is the function of this protein?
Part of an ABC transporter complex involved in ferric-petrobactin uptake.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Petrobactin import ATP-binding protein FpuD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PNP_CUPPJ
Sequence: MSMFNKVVKQFQWGQHTVRMETGEIARQAGGAVIVDVEDTVVLATVVAAKSPKPGQDFFPLTVDYIEKTYAAGKIPGGFFKREGRPSENETLTSRLIDRPLRPLFPEGFYNDVQVVVHVVSLNPEIPADIPALIGASAALAVSGIPFNGPVGAARIGYKDGQYLLNPTRSQMATSDLDLVVAGTERAVLMVESEANQLSEDVMLGAVVYGHEQMQIAINAIHDLVREGGKPEWDWAPAPKNEALIAKVTEVALPLLQEAYQLRQKSARSQKLKEVSANVTAALAEAGVDADKVEVGNIMFDLEAKIVRGQILGGEPRIDGRDTRTVRPIEIRSSVLPRAHGSALFTRGETQALVVATLGTKSDEQIIDALAGEYRDRFMLHYNMPPFATGETGRVGSPKRREIGHGRLAKRALIPVLPKDDEFAYTIRLVSEITESNGSSSMASVCGGCLALMDAGVPVKAHVAGVAMGLILEGNKFAVLTDILGDEDHLGDMDFKVAGTDNGITALQMDIKVQGITKEIMQVALAQAKEGRLHILGAMQGAMGHARTELSAHAPRMITMKIHPDKIREVIGKGGSTIQALTKETGTTIDIQEDGTITIASTSTDGMAEAKRRIEGITAEAEVGKIYNGTVLKLLDFGAIVNILPGKDGLLHISEIVNERVKDIKDWLKEGQQLRVKLIQADEKGRLRLSLKAALAEEGGSISPVNAGEAAPAPAPAAAPATPSDQQQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRP14_YEAST
Sequence: MANTGCLSPGAFLSKVPEFFQTANEKHITVRLTAKRLIEHDPVEGNLEFDSTNHPDYDVSKKASEISVSSRSDREYPLLIRMSYGSHDKKTKCSTVVKASELDQFWQEYSSVFKGGMQNLIKKKKKKSKNGTISKTGKKNKVAKKN
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:7925282, PubMed:10573124).  The SRP complex is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences (PubMed:10573124).  It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting (PubMed:10573124).  SRP14 binds scR1 RNA to form the probable Alu domain of SRP responsible for elongation arrest (PubMed:10573124).
What are the official names of this protein?
Signal recognition particle subunit SRP14, Signal recognition particle 14 kDa protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SRP14 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ERA_GLAP5
Sequence: MTDQKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRILGIKTEGAYQEIYVDTPGLHIEEKRAINRLMNRAAASAIGDVDMVIFVVEGTKWTDDDEMVLNKLRSTKAPVILAINKVDNIKEKEELLPHLTALSQKFPFKEIIPISAQRGKNVHILEKFVRESLKEGIHHYPEDYVTDRSQRFMASEIIREKLMRFMGEELPYSVTVEIEQFKTNERGTYEINGLILVEREGQKKMVIGNKGQKIKVIGTEARADMERLFDNKVHLELWVKVKAGWADDERALRSLGYIDE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: BIOH_PROMH
Sequence: MNKLYWQTLGEGKTHLVLLHGWGLNAQVWQSIITRLSSHFTLHLVDLPGYGRSQGFPVLTLKEMADIVFSQAPEKKAIWLGWSLGGLVASRIALDNPNNVRALITVASSPCFAAHEAWPGIKPDVLKGFEQQLSDNFHRTVERFLALQTLGTQSAREDTKALKAVVLAQPLPSVETLNGGLEILRTEDLREQLTTLCCPFIRLYGYLDGLVPRKVAALLDARYPDSPSVIFRHAAHAPFISHPDEFSETLLKQCEALSILA
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLP19_ARATH
Sequence: MMKGYITLSFLIILIFNFLDEFAASTRHLCDPDQSDAILEFKNEFETLEESCFDSNIPLKTESWTNNSDCCYWDGIKCDAKFGDVIELDLSFSCLRGQLNSNSSLFRLPQLRFLTTLDLSNNDFIGQIPSSLETLSNLTTLDLSRNHFSGRIPSSIGNLSHLIFVDFSHNNFSGQIPSSLGYLSHLTSFNLSYNNFSGRVPSSIGNLSYLTTLRLSRNSFFGELPSSLGSLFHLTDLILDTNHFVGKIPSSLGNLSHLTSIDLHKNNFVGEIPFSLGNLSCLTSFILSDNNIVGEIPSSFGNLNQLDILNVKSNKLSGSFPIALLNLRKLSTLSLFNNRLTGTLPSNMSSLSNLKLFDATENHFTGPLPSSLFNIPSLKTITLENNQLNGSLGFGNISSYSNLTVLRLGNNNFRGPIHRSISKLVNLKELDLSNYNTQGLVDFTIFSHLKSIEYLNLSHLNTTTTIDMYEILSSFKLLDTLDLSGSHVSTTNKSSLSNSSLVLISQLYLSGCGITEFPKFLRSQELMLTLDISNNKIKGQVPGWLWMLPVLNYVNLSNNTFIGFERSTKLGLTSIQEPPAMRQLFCSNNNFTGNIPSFICELPYLSTLDFSNNKFNGSIPTCMGNIQSPYLQALNLRHNRLSGLLPENIFESLISLDVGHNQLVGKLPRSLSHISSLGLLNVESNKISDTFPLWLSSLQELQVLVLRSNAFYGPIEKTQFSKLRIIDISGNQFNGTLPANFFVNWTAMFSLDENEDQSNGETMSNMYMSTDYFYFDSMVLMNKGVEMELERVLKVFTVIDFSGNKFEGEIPKSIGLLKELHVLNLSNNALSGHIASSMGNLMALESLDVSQNKLSGEIPQELGKLTYLAYMNFSHNQLVGLLPGGTQFQTQKCSSFEDNHGLYGPSLEKICDIHGKTPQQSDMAPEPEEDEEEVISWIAAVIGFILGTALGLTFGCILFSYKPDWFKNPFVRDKRRNIGTITH
What are the official names of this protein?
Receptor-like protein 19, AtRLP19.
What is the protein family that this protein belongs to?
Belongs to the RLP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: EASF_ARTOC
Sequence: MGNTNPPHILDIRRSKFEESIPKQVEAGLLSSPKTLPALLFYSTEGIQHWNRHSHAPDFYPRHEEIQILKEQATDMAASIADGSVVVDLGSASLDKVIHLLEALEAAQKKVTYYALDLSFSELTSTLQAIPTEQFIHVQFSALHGTFEDGLHWLKETPVIQDQPHCLLLFGLTIGNFSRPNAAAFLRNIASQALTGSPSQSSILLTLDSCKVPTKVTRAYTAEGVVPFALESLRYANTLFPQDGEERVFDPHDWHFLSEWNYILGRHEASLIPQSRDIKLGSPLDRIVVAKHEKIRFGCSYKYDCGERKELFESAGLHDVKIWSKEGCDVAFYQLKCCPN
What is the function of this protein?
4-dimethylallyltryptophan N-methyltransferase; part of the gene cluster that mediates the biosynthesis of fungal ergot alkaloid (PubMed:22403186).  DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:22403186).  The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (PubMed:22403186).  The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by easD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:22403186).  Chanoclavine-I aldehyde is the precursor of ergoamides and ergopeptines in Clavicipitaceae, and clavine-type alcaloids such as fumiclavine in Trichocomaceae (PubMed:22403186).  However, the metabolites downstream of chanoclavine-I aldehyde in Arthrodermataceae have not been identified yet (PubMed:22403186).
What are the official names of this protein?
4-dimethylallyltryptophan N-methyltransferase easF, 4-dimethylallyltryptophan methyltransferase, Ergot alkaloid synthesis protein F.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: ATPB2_BURP1
Sequence: MADPQATNGTGAACAERDASDVGDARDEGAGRVVAVRGAVIDVAFDGGALPALNEALTIPVDGAAPILAEVHAHLSDAAVRALALGPTGGLRRGAAVRATGGPIRVPVGDAVLGRLLSVTGAPGDDGAALAADVERRPIHRGAPLLAEQKSANALFATGIKVIDLLAPLAQGGKAAMFGGAGVGKTVLVMELIHAMVERYRGISVFAGIGERSREGHEMLLDMRGSGVLGRTVLVYGQMNEPPGARWRVPLTALAIAEYFRDERAQNVLLLMDNVFRFVQAGAEVSGLLGRLPSRVGYQPTLASEVAALQERIASVEGAAVTAIEAVYVPADDFTDPAVTAIAAHVDSMVVLSRAMAAEGMYPAIDPVASSSILLDPLVVGEAHVEVAIEVRRVIEHYRELQDVIALLGIDELGADDRRLVGRARRLQRFLTQPFAVTEAFTGQAGASVEIADTIAGCRAILRGDCDDWRESSLYMVGTLDDARRKEAAAREADARREAAAAASGAGPGTTSDPASGSAEPQGARHGR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 2, ATP synthase F1 sector subunit beta 2, F-ATPase subunit beta 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UP02_EPHDI
Sequence: DPLGSTEEFSR
What are the official names of this protein?
Unknown protein 2.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: CALM1_DAUCA
Sequence: MADQLTDDQISEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin-1/11/16, CaM-1/11/16.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: FDHE_SALCH
Sequence: MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNVYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEANDQGKPPLDIHVLPRDKHWQKLLHSLIAELKPEMSGPALAVIENLEKASEQELEQMASALFASDFASVSSDKAPFIWAALSLYWAQMASLIPGKARAEYGEARQYCPVCGSMPVSSMVQISTTQGLRYLHCNLCETEWHVVRVKCSNCEQSRDLHYWSLENEQAAVKAESCGDCGTYLKILYQEKDPKVEAVADDLASLVLDARMEQEGFARSSINPFLFPGEGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_LACLS
Sequence: MTNYLLEIGLEEIPAHLVTPSINQLAERMEAFLNENRLKFDKIIKFSTPRRLALIVEGLSESSEAIDEEVKGPSAKIAKDAEGNWSKAIQGFSRGQGATPDDLILKGDYYYAKKHVDGVKAEEILSKVGDEVIAKMTFSTYMKWGNNDFLFVRPIQWIVSLLEDEIVAFDLLDVTANRFSRGHRFLANVEIELKNANDYASKMPENFVLVDAEHRKAEISAQILALASENNWQVTLHKDLLEEVNNIVEYPTAFVGSFDPKYLSVPAEVLVTSMRDNQRYFEVYNQEGQLAPNFISVRNGNAEHIENVVLGNEKVLVARLEDAEFFWKEDQKLKIEDLVAKLGKVTFHAKIGSITEHMARTKLIAAKLADIAGLTDEEKVDVARSAEIYKFDLLTGMVGEFDELQGVMGEKYALLAGENANVAAAIREHYMPTSADGQLPETKVGSVLAAADKIDSVLSFFNVGLIPSGSNDPYALRRAVQGLIRIIEKMNWHFDLSLFIDQFEGQNHAEILEFVKARVQKLLLEKLDRYDIVEAAINSSNFDITNMMESAFVIDGHKLHEPFKPAIENVSRSINLVKKAADIAEINPALFEEDTEQALYDAVISLQNQWTYKPCEEKFRAIVHTLAPAIEAFFDNVMVMAEDLAVRDNRIALLSEVVALTSVMADFSLINTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PB2_I000F
Sequence: MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIMEMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGPTTSTVHYPKVYKTYFEKIERLKHGTFGPVRFRNQVKIRRRVDINPGHADLSSKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKIAPLMVAYMFERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMVGILPDMTPNTEMSLRGVRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQDPTMLYNKMEFEPFQSLVLKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGALTEDPNEGTAGVESAVLRGFLILAKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: FTSH_KOSOT
Sequence: MDQRPKFGMILFYIVLGVFLMVALRGLYTTDTNLSVPYNRFLEDVNDKKIIKIVIYDDGRIVYTTSESSKRSLETKVSPQTLSTDRFQNYIDQLVTDGVNVVYEKGNDSLFWVNLLGTIIPLAIIVFIWFFAMRSLSGRNSQAFTFTKSPAKKYLSNDKNVTFKDVAGVDEAIEELQDAVNYLKNPNAFSQTGARMPKGILLVGPPGTGKTLLARAVAGEANVPFFYISGSDFVELFVGVGAARVRDLFSQAKASAPSIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQILVEMDGFDAKTGVIVMAATNRPDILDHALLRPGRFDKKITVDPPDVKGRAEILKIHMRGKPVDPDVDVWLLARRTPGFVGADLENLVNEAAILAARRKKKIIGMKELEEAIDRVIAGPARKSRIMNPKEKKIVAYHELGHAIVGLALPNAYPVHKVTVIPRGSASLGFTESLPSEDRYLVSRSEMLDNLAQILGGRAAEEIVFGEITTGAANDLERATQMARTMVCQLGMSDRLGPIAWGKEEGEVFLGRELTRMRNYSEEIASEIDNEVKKIVIEAHERARKLVEKFRDKLDKAAEYLIEKETITGKELAEIVGLAESGNYYRDPLAETKGSKRKVSAVSTNEEAKEGNEDEKN
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: KEFG_CITK8
Sequence: MMSQPAKVLLLYAHPESQDSVANRVLLKPAMQLSNVTVHDLYAHYPDFFIDIAHEQALLREHDVIVFQHPLYTYSCPALLKEWLDRVLSRGFASGPGGNQLAGKYWRSVITTGEPESAYRYDALNRYPMTDVLRPFELTAAMCRMHWMSPIIIYWARRQSEQELASHAKAYGEWLANPVLAGGR
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefB.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefG, Putative quinone oxidoreductase KefG.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NDK_ACET2
Sequence: MERTLVILKPDSVKRKLVGEIISRFEKRNFTILHLKMMNIDRELACEHYSHVKDKPFFNDMIDYITSGPVVVMVLSGYRVIEAVRSMVGATSNFDSKPGTIRGDYGYHRFENLIHASDSCESAEIEIKRFFPELDS
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_DEIDV
Sequence: MQNLSSLDVKGKRVLVRVDYNVPVKDGVVQDDTRVTASLPTVNALLGAGASVVLMSHFGRPKGGPEDKYSLRPVAPVLEKVLGRPVKFIASLPGSDETLQAVQELQPGEVALLENVRFEAGEEKNNPELNQKLARLGDAFVLDAFGSAHRAHSSVSGVAAQLPHAAGTLLQTEVEALGRLIEAPESPYVVIIGGAKVSDKIKVIENLLPKVDRMLIGGGMMFTFIKARGGVIGNSLVEDDQVDYARGLLEQFGDKLMLPTDAVAADRFAADADTRVVPADQIPEGWMGLDIGPDTQQAYTEALRGAKTVFWNGPMGVFEFPAFAAGTNAVAAAVGSLKNQAYTVVGGGDSVSAINKSGKADQIDHISTGGGASLELLEGKALPGVEAMR
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TINAG_BOVIN
Sequence: MCAGYKILILAYLTTEIWMERQYLSQREVDPGAEFTRNHTISEGTRFKRAVFEGQYCRRFGCCADRDDGCVTQFYEADALCYCDKFCERENSDCCPDYKSFCREEKGWPPRTKPWSPEGCHRDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVQPGLIEHVNKGDYGWTAQNYSQFWGMTLEEGFKYRLGTLPPSPLLLSMNEVTASLTKTTDLPEFFIASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSQGRYTANLSPQNLISCCAKKRHGCNSGSVDRAWWYLRKRGLVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATTPCPNSIEKSNRIYQCSPPYRVSSNETEIMREIMQNGPVQAIMQVHEDFFNYKTGIYRHITSTNEDSEKYRKFRTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSADEP
What is the function of this protein?
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3.  This is a non catalytic peptidase C1 family protein (By similarity).
What are the official names of this protein?
Tubulointerstitial nephritis antigen, TIN-Ag.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane.
Protein: MNME_PROM5
Sequence: MESIVDTEDTIAAIASAISLGKGGIAVIRVTGEEAINSCKNIVETKSKYAWESHRVFHGYVKDNLENKYIDEILISVMHSPNSFTGEDVVELHCHGGVIVVNKVMDTLLSNNNKVRIANPGEFSQRAFLNGKIDLTQAESINQLINAKNLKSAEIAFNGVKGEIKKKIDVIKNDLIEQLSEIEARVDFEEDFSDFNYHDFSRSIKNIKEKIEILIENTKRGASIHNGISIALIGKTNVGKSSLLNLLSKKEKAIVTNIPGTTRDMIEVNLTIKDIPIKLVDTAGIRDTDEYIENIGIEKTFEMIQKSDYIIYLYSLEDGFNKDDEEIISKIPREKLITILGNKKDLIDSKKNDQKTFSSDIVLMSIKNNEGEKDLVDKIVKKCGSKEFENIDIFLNERQISNLRDCLKNLNDTDPIIANQLPFDLLSIEVRDGIKNLSRITGQELTEDLLNNIFSKFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.