PharMolix/UniProtQA huggingface dataset:
Protein: CAPP_ECOSM
Sequence: MNEQYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDLYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGHEPDPRVEQALMVTIAGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: FLGI_SALSV
Sequence: MFKALAGIVLALVATLAHAERIRDLTSVQGVRENSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASYPPFARQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAIIERELPTQFGAGNTINLQLNDEDFTMAQQITDAINRARGYGSATALDARTVQVRVPSGNSSQVRFLADIQNMEVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQLNVNQPNTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSANLNSVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: TGFI1_MOUSE
Sequence: MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQTGSGESSGTTGDKDHLYSTVCKPRSPKPVAPVAPPFSSSSGVLGNGLCELDRLLQELNATQFNITDEIMSQFPSSKMAEGEEKEDQSEDKSSPTVPPSPFPAPSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAASPTREGCPSPPGQTSKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCSGCSTTLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFSGGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERASKPYCQPCFLKLFG
What is the function of this protein?
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus.  Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.  May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity.  In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity.  May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence.  May have a zinc-dependent DNA-binding activity.
What are the official names of this protein?
Transforming growth factor beta-1-induced transcript 1 protein, Androgen receptor-associated protein of 55 kDa, Hydrogen peroxide-inducible clone 5 protein, Hic-5, TGF beta-stimulated clone 5, TSC-5.
What is the protein family that this protein belongs to?
Belongs to the paxillin family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers.
Protein: ISPH_ROSDO
Sequence: MTKPPLTLYLAAPRGFCAGVDRAIKIVELALDKWGAPVYVRHEIVHNKFVVDGLRAKGAIFVEELSECPDDRPVIFSAHGVPKSVPTAAQARNLVYVDATCPLVSKVHIEAQRHADNGLQMIMIGHAGHPETVGTMGQLPEGEVLLVETPEDVATVKVRDPAKLAYVTQTTLSVDDTADVVHALQQRFPLIVGPHKEDICYATTNRQEAVKAMAPKCDAMLVVGAPNSSNSRRLVEVGARAGCQYAQLVQRATDIDWRALDGISSIGITAGASAPEVLINEVIAAFDAHYDVTQEVVETAVENVEFKVPRVLREPA
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: NADK2_SYNP6
Sequence: MPDVGIIYNDSKPRACTIAEELQQQLQDRGWGVRLATSQSGLLGYSNPDTVICHTPVESLVPRGFDASLRWAIVLGGDGTVLAAARQLAPIGVPMLTVNTGHLGFLAEAYLDSLPAAIEQLCKGEYSIEERTMMEVKVLRRELIRWEALSLNEMALHREPLTSMCHFEVAIGKHVPVDIAADGVIVSTPTGSTAYSLSSGGPVVTPDVPVFQLVPICPHSLASRALVFANREPMTIFPATPERLMMVVDGNAGCYVWPEDRVLIQRSRYPAQFIRLQPNEFFRVLREKLGWGLPHVAKPSAPDQS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase 2, ATP-dependent NAD kinase 2.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBB_WIGBR
Sequence: MNKKLLSEFGDPVQRVKNALQSLKRGNGILVLDDENRENEGDMIFAAENMTVNQMALAIRFGSGIVCICLTKEKCKILNLPMMVKKNNSKYKTAFTVSIESAYGITTGVSAYDRIITIKTAIKDNAKPDDLNRPGHVFPLQAHPGGILSRAGHTEAAVDLTKLAGLKPAGVICEVMNDDGSMARMPEIINFSKKYNMPVLIIKDIIEYYNFIN
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: Y144_MYCGE
Sequence: MDPQNKSPKPQVKSTRLVVKKQPAGVVFPKLSIPVNDFEKTVTLTRAQKKEAKLLKKAQRKANKLNNKQDSTFFNSASGETNNTILPPGVKNQADNKTNRFSKFISFFTSSKNKQPDEITERLVDDPTVKNRFSAFNKKLIWVLKDKKLRARAWKIVGYTNLVIVAFFAGLLAVMNKFITLSSVEYPAIALQLPINNALWGISIFVISIVTLPFWTMFILFLMGVKDVRTSRSIHYFIWIVLIINVVLLLVSCLLMIAAYAHLDGYNIWRNLESLNPNN
What are the official names of this protein?
Uncharacterized protein MG144.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RP35_VACCT
Sequence: MQHPREENSIVVELEPSLATFIKQGFNNLVKWPLLNIGIVLSNTSTAVNEEWLTAVEHIPTMKIFYKHIHKILTREMGFLVYLKRSQSERDNYITLYDFDYYIIDKDTNSVTMVDKPTELKETLLHVFQEYRLKSSQTIELIAFSSGTVINEDIVSKLTFLDVEVFNREYNNVKTIIDPDFVFRSPFIVISPMGKLTFFVEVYSWFDFKSCFKDIIDFLEGALIANIHNHMIKVGDCDETVSSYNPESGMLFVNDLMTMNIVNFFGCNSRLESYHRFDMTKVDVELFIKALSDACKKILSASNRL
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of D6 and A7, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 35 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 35 kDa subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle.
Protein: ATPG_PARL1
Sequence: MASLKDLRNRIASVKATQKITKAMQMVAAAKLRRAQEAAEAARPYAERMDRVLANLATGMTGRSDAPALLAGTGSDQVHLVIVATADRGLCGGFNSSIVRLARQHINKLVGEGKTVKILTVGRKGRDALKRDHASRIVKSYEFTGIRHIGFEQAEDISRTVIDLFEAGEFDVATIFYSKFVNVVSQIPTAQQLIPASVPADAGGSVDLGGAVYEYEPDEGEILKDILPRNLSVQIFRALLENVAGEFGAKMSAMDNATRNAGDMIKKLNITYNRSRQAMITKELIEIISGAEAL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AVL9_PONAB
Sequence: MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATVFGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGASLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHGLSDCSQYRPRKSMSEDGGLQESNPCADDFVSASTADVSHTNLGTVRKVIAGNHGEDAAMKTEEPLFQVEDSSKGQEPNDTNQYLKPPSRPSPDSSESDWETLDPSVLEDPNSKEREQLGSDQTNLFPKDSVPSESLPITVQPQANTGQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQKHLGDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKILSDYGTTFVTAWKNTHDYRVWNSNKHPALAEINPNSVQNSERGKKIGNVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTTSTSQSLTEPPDGKP
What is the function of this protein?
Functions in cell migration.
What are the official names of this protein?
Late secretory pathway protein AVL9 homolog.
What is the protein family that this protein belongs to?
Belongs to the AVL9 family.
What are the subcellular locations of this protein?
Recycling endosome. Membrane; Single-pass membrane protein.
Protein: RPIA_LACJO
Sequence: MNKTEQDQLKKEAATKAAKMVEPNSVLGVGTGSTVAFFIDALGERKEREGFSLKHIVTTSNRSKKQLEGLGFKVDELADIDQADLTVDGADRVDDNLDGIKGGGGALTLEKNVAINSKKIIWIVDESKLVHHLSGFPLPVEVLPVSAEQNFKRFEAEGLKPQWRLNDEGKRYVTHYGNYIIDLAADPTPVPHGLADYLDHTVGVVEHGLFLDMCDEVIIAHSDGTIEDKKRK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: D1_ONCVO
Sequence: VVSTSPTKLVNVSYNNLTVNLGNELTPTQVKNQPTKVSWDAEPGALYTLVMTDPDAPSRKNPVFREWHHWLIINISGQNVSSGTVLSDYIGSGPPKGTGLHRYVFLVYKQPGSITDTQHGGNRPNFKVMDFANKHHLGNPVAGNFFQAKHED
What are the official names of this protein?
Protein D1.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylethanolamine-binding protein family.
Protein: PSB2B_ARATH
Sequence: MECVFGLVGNGFAIVAADTSAVHSILLHKNKEDKIMTLDSHKLVAASGEPGDRVQFTEYVQKNVSLYQFRNGIPLSTAAAANFTRGELATALRKNPYSVNILMAGYDKEAGASLYYIDYIATLHKVDKGAFGYGSYFSLSTMDRHYRSDMSVEEAIELVDKCILEIRSRLVIAPPNFVIKIVDKDGAREYGWRISTADA
What is the function of this protein?
Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit beta type-2-B, 20S proteasome beta subunit D-2, Proteasome component GA, Proteasome subunit beta type-4.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: THIQ_VIBPA
Sequence: MLVLDDVQYTYQRELFRFELSIERGQIVSLMGPSGAGKSTLLALVAGFIHPDQGDIRVDGESIVRKEPYQRPFSMLFQEHNLFSHLSVRDNIGLGLHPGLKLTVDQKRQVEQAAQQVGVAEYLDRLPEHLSGGQRQRVALARCFVQPHPMWLLDEPFSALDPVLREEMLSLVKKLAAERGITVLMVTHHLSDAKAIASHFAFVANGKVEAVGEIDALTAEHPSKTLQAFVRAAG
What is the function of this protein?
Part of the ABC transporter complex ThiBPQ involved in thiamine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Thiamine import ATP-binding protein ThiQ.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VATG_DROME
Sequence: MASQTQGIQQLLAAEKKAAEKVAEARKRKARRLKQAKDEATEEIEKFRQERERAFKEFEAKHMGSREGVAAKIDADIRVKLADMDRAIQTRKDPFILEILQYVYNISPEVHKNYNHK
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334).  Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334).
What are the official names of this protein?
V-type proton ATPase subunit G, V-ATPase subunit G, V-ATPase 13 kDa subunit, Vacuolar proton pump subunit G.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase G subunit family.
Protein: VIRD4_AGRRH
Sequence: MNSSKITPQRLALSIVCSLAAGFCAASLYATFRHGFNGEAMMTFSVFAFWYETPLYIGHATPVFFCGLSIIIATSVVVLLSQLIISLRNREHHGTARWAAFGEMRHAGYLQRYNRIKGPVFGKTCGPLWFGNYLTNGEQPHSLVVAPTRAGKGVGVVIPTLLTFKGTVIALDVKGELFELTSRARKSSGDAVFKFSPLDPERRTHCYNPVLDIAALPPERQFTETRRLAANLITAKGKGAEGFIDGARDLFVAGILTCIERGTPTIGAVYDLFAQPGEKYKLFAHLAEESRNKEAQRIFDNMAGNDTKILTSYTSVLGDGGLNLWADPLVKAATSRSDFSVYDLRRKRTCVYLCVSPNDLEVVAPLMRLLFQQVVSILQRSLPGKDERYEVLFLLDEFKHLGKLEAIETAITTIAGYKGRFMFIIQSLSALSGTYDEAGKQNFLSNTGVQVFMATADDETPTYISKAIGEYTFQARSTSYSQARMFDHNIQISDQGAPLLRPEQVRLLDDKSEIVLIKGQPPLKLRKVRYYSDRMLRRLFECQIGALPEPASLMLAQDVHQDGQDHLSQQAAVTAALGLGDIDSLVNNGETPTQQNSDMNDEQDNLAIGIYAPQVSVEIDDVVEDANARGVAPVSSVPAEMAPALSAQQQLLGQIIALQQRYRPVSSNPIE
What are the official names of this protein?
Protein VirD4.
What is the protein family that this protein belongs to?
Belongs to the VirD4/TraG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOB_SYNS3
Sequence: MSSSAIQVAKTVTYLPDLVEVQRASFKWFLDKGLIEELESFSPITDYTGKLELHFVGSEYRLKRPRHDVEEAKRRDATFASQMYVTCRLVNKETGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDKNGRRTYNASVIPNRGAWLKFETDKNDLLHVRVDKTRKINAHVLMRAMGLSDNDVVDKLRHPEYYKKSIEAANDEGISSEDQALLELYKKLRPGEPPSVSGGQQLLQTRFFDPKRYDLGRVGRYKINKKLRLTIPDSVRTLTHEDVLSTLDYLINLELDVGGASLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWRVENGVVQKSGDPIYLSADLEDECRVAPGDVATDADGQILAELIPVRYRQDFEKVPPEQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTGLETQVARDSGMVPISRVNGTVTFVDATAIVVRDEEGYDHTHFLQKYQRSNQDTCLNQRPIVRQGDPVIIGQVLADGSACEGGEIALGQNVLIAYMPWEGYNYEDAILVSERLVNDDLYTSVHIEKYEIEARQTKLGPEEITREIPNVAEESLGNLDEMGIIRIGAFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPSTERGRVVDVRIYTREQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDICLNPLGVPSRMNVGQVFELLMGWAAANLDCRVKIVPFDEMYGPEKSQQTVQAYLKEAASQPGKDWIYNPEDPGKLLLRDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIAVFTDEGKEVDLMQDVNPRRSTPSRPTYESLGVADYDED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: GBLP_MACFA
Sequence: MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR
What is the function of this protein?
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules.  Interacts with a wide variety of proteins and plays a role in many cellular processes.  Component of the 40S ribosomal subunit involved in translational repression.  Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation.  May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6.  Inhibits the activity of SRC kinases including SRC, LCK and YES1.  Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle.  Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer.  Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC.  Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix.  Involved in PKC-dependent translocation of ADAM12 to the cell membrane.  Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A.  Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation.  Required for PTK2/FAK1 phosphorylation and dephosphorylation.  Regulates internalization of the muscarinic receptor CHRM2.  Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L.  Inhibits TRPM6 channel activity.  Regulates cell surface expression of some GPCRs such as TBXA2R.  Plays a role in regulation of FLT1-mediated cell migration (By similarity).  Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-2-like 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Perikaryon. Cell projection, dendrite. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery (By similarity). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity).
Protein: ARGJ_STRAW
Sequence: MSVTAAQGFTASGIAAGIKENGNPDLALVVNNGPRLAAAGVFTSNRVKAAPVLWSEQVLKGGVVSAVVLNSGGANACTGPKGFQDTHATAEKVAETLDLNAGEVAVASTGLIGVLLPMDKLLPGVERAVAGLSEHGGEKAAIAIKTTDTVHKTSVVTKDGWTVGGMAKGAGMLAPGLATMLVVLTTDADLDRDALDRALRAATRTTFDRVDSDGCMSTNDTVLLLASGASEVTPKQEEFAEAVRAVCDDLGQQLIQDAEGASKDIKVEVVGAATEDDAVEVGRSIARNNLLKCAIHGEDPNWGRVLSAIGTTRAAFEPDQLNVAINGVWVCKKGGVGEDRDLVDMRYREVHIVADLAAGTETATIWTNDLTADYVHENSAYSS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBE4A_MOUSE
Sequence: MTDQENNNNISSNPFAALFGSLADAKQFAAIQKEQLKQQSDELPASPDDSDNSVSESLDEFDYSVSEISRSFRTHQEMCEQLNINHMIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQAIFARLLLQDPGNHLISMTSSTTLNLSADRDAGERHIFCYLYSCFQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAHFEDVTEFLEEVIEALLLDEEVRTFPEVMIPVFDILLSRIKDLELCQILLYAYLDILLYFTRQKDMAKVFLEYIQPKDPSNGQMYQKTLLGVILNISCLLKTPGVVENHGFFLNPSRSSPQEIKVQEANIHQFMAQFHEKIYQMLKNLLQLSPETKHCILFWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNPTYCVLKDLNDEERKIKSVHMRGLDKETCLIPAVQEPTFPQSYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQSSSPAADNLREQFERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAIGNEGSQPIELSFPLPDGYSSLAYVPEFFADNLGDFLIFLRRFAEDILETSADSLEHVLHFITIFTGSIERMKNPHLRAKLAEVLEAVMPHLDQTPSPLVSSVFHRKRVFCNFPYAPQLAEALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDCYRESIKYLSKIKIQQIEKDRGEWESLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLSFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIVAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMSDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQPE
What is the function of this protein?
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases.  May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.  Mediates 'Lys-48'-linked polyubiquitination of substrates.
What are the official names of this protein?
Ubiquitin conjugation factor E4 A.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin conjugation factor E4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_CHESB
Sequence: MANVVVVGSQWGDEGKGKIVDWLSERADVVVRYQGGHNAGHTLVIDGVSYKLSLLPSGVVRSGKLSLIGNGVVFDPHAFVAEIERLKGQGISVTPESLKVAENTALILSLHRELDAFREDAASNSGTKIGTTRRGIGPAYEDKVGRRAIRVMDLADPETLSLKVDRLLTHHNALRRGLGHAEVSHEAIMQELTSVADKILPFVDRVWKILEDARRAGSRILFEGAQGTMLDIDHGTYPFVTSSNTVAGQAATGSGLGPGAVGYVLGITKAYTTRVGEGPFPTEQDNEIGEFLGNRGHEFGTVTGRKRRCGWFDAVQVRQSVVTNGMSGIALTKLDVLDGMEEIKVCTGYRLDGQVIDYLPASQGAQARLDPIYETLEGWKETTRGARKWNDLPAQAVKYVRHIEELIGAPVAILSTSPEREDAILVKDPFQD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADA29_MOUSE
Sequence: MNMIEALLSMRVLFLTQVFGIFLCFPGLTKAGHLHYHSSIEVVIPMKVTEKTRGMNLPNWISYSLKLGGQRYIIHMKIKNLFLTRHLPVFTYSDQDSLLEDYPFVQDDCYYQGYVEGDSESLVSLSSCFGGFHGLLEINNIVYEIMPKKFSRKFEHLVYKVDINKTESRGSSLMQDNITCQVELQKSGNPILKQSSFEDWWTHTKIVELVVVVDKTLYDHYGNYTVMLSDLYSVINIVDTIYEVIGIKILLVGVEVWNKKNLIVIDDVSKSLRLYCRWKASNFLHRLKHDVSHLFIYRHLRGLSGIGSTGGICDPKRSCAVVTFIDRTLNLRAIGVAHHLGHNLGMKHDEDICKCSYSKCIMHMDSPPIPKFSNCSYNYFWSYTVKNTRCLMENMYTKDIFDRTRCGNGVVEDKEQCDCGSLRNCTNDLCCMSNCTLSTGSSCAFGLCCKNCQFLPSGTLCRKRDNICDLPEWCNGTSHECPDDAYVEDGIPCGVSAYCYEKQCNDRNEHCRQIFGQNAKTASVHCYREINTKGDRFGHCGLQGPTYIKCKSNDALCGRIQCDNVVQIPNMKDHSTIHFALVKNVSCWGTDYHTGTSLTDIGDVKDGTECEQNHICINRHCVHISTLDSNCTPAFCNYRGICNNKHHCHCNFHWDPPNCMIRGHGGSVDSGLPPKTNKKKHFFYLLLLQLIILACLLSCLLWLLFNIKGSKRKPQVQPTPVKTKKVSKKVPSQKPSPVPSPSLPQLRMPSRSASPTSSIKSTN
What is the function of this protein?
May be involved in spermatogenesis and fertilization.  Seems to be a non catalytic metalloprotease-like protein (By similarity).
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 29, ADAM 29.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.