PharMolix/UniProtQA huggingface dataset:
Protein: T1S1_METJA
Sequence: MFYKEENFKKTEIGEIPEDWEIVELKDVCKKIKAGGTPKTSVEEYYKNGTIPFVKIEDITNSNKYLTNTKIKITEEGLNNSNAWIVPKNSVLFAMYGSIGETAINKIEVATNQAILGIIPKDNILESEFLYYILAKNKNYYSKLGMQTTQKNLNAQIVKSFKIPLPPLEEQKQIAKILTKIDEGIEIIEKSINKLERIKKGLMHKLLTKGIGHSRFKKSEIGEIPEDWEVFEIKDIFEVKTGTTPSTKKSEYWENGEINWITPLDLSRLNEKIYIGSSERKVTKIALEKCNLNLIPKGSIIISTRAPVGYVAVLTVESTFNQGCKGLFQKNNDSVNTEFYAYYLKFKKNLLENLSGGSTFKELSKSMLENFKIPLPPLEEQKQIAKILSSVDKSIELKKQKKEKLQRMKKKIMELLLTGKVRVKT
What is the function of this protein?
The specificity (S) subunit of a type I restriction enzyme; this subunit dictates DNA sequence specificity.  The M and S subunits together form a methyltransferase (MTase) that methylates A-3 on the top and bottom strands of the sequence 5'-CAAN(7)TGG-3'.  In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site.  Whether the DNA is cut or modified depends on the methylation state of the target sequence.  When the target site is unmodified, the DNA is cut.  When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated (PubMed:12654995) (Probable).  After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage (By similarity).
What are the official names of this protein?
Type I restriction enzyme MjaVII specificity subunit, S protein, Type I specificity subunit S.MjaVII, S.MjaVII, Type-1 restriction enzyme MjaXIP specificity subunit, S.MjaXIP.
What is the protein family that this protein belongs to?
Belongs to the type-I restriction system S methylase family.
Protein: HIS4_ECO7I
Sequence: MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSPDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGEINDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSI_LYSSC
Sequence: MTEKIVLPPQSGKPSDVERIKTESNYLRGTLERTMNDPLSSGIPEDDNRLMKFHGSYLQDDRDLRNERQRQKLEPAYQFMVRVRTPGGAATPAQWLVMDEMARKYGNGSLKLTTRQAFQVHGILKWNVKKYMQEINEVLLDSLAACGDVNRNVMCNVNPNQSALHEEVYNWSAKLSEHLLPRTRAYHELWLDGEKVIDSQDDEIEPIYGAQYLPRKFKIAIAIPPSNDVDVFSQDIGLIAIVEDEKLIGFNVAVGGGMGMTHGDHATYPQLAREIGFITPDKLLETAEKIITIQRDYGNRSVRKNARFKYTIDARGLEWFNEELTRRLGWSIQEARPYTFERTGDEFGWIKGAEGKWHYTLFIQNGRIKDFQDYKLLTGLREIAKVHTGDFRLTPNQNLMISNVTPQKKKKIAAIIEQYKLTDGAHYSALRRNSIACVSLPTCGLAMAEAERYLPSLITKIETIIDETGLNDTEIVIRMSGCPNGCSRAAMAEIGFIGKGPGKYNLYLGASFTGNRLNKIYRENIGEEEILAELRPILVHYAKERLVGEHFGDFVIRAGYVTAVYDGREFHV
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: MRAY_ENTHR
Sequence: MEWTQALIPIVSSCAMTIAAMPLFIGYFQMKKQGQAIREEGPKWHNVKAGTPTMGGLVFLVAAILTGIWVGRPWQNQSTPTLFILLFVLALYGVIGFLDDFIKIFKKRNMGLNSKQKLLGQIIGGIIFYLVYRSEGYPGTLNFFGIELPLGLFYGVFAIFWLVGFSNAVNLTDGIDGLVAGLGTISFATYGIIAWHQQQYDVLVICLSVLGGLLGFFAYNRKPAKIFMGDVGSLALGGLLAAISIMLNQEWTLLLVGLIYVMETASVMLQVTSFKLTGKRIFKMSPIHHHFGMCGWSEWKIDIIFWLVSIVTSLITLWFIW
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRH_BRUSU
Sequence: MTGKPAYKRVLLKASGEALMGSQGFGIDVSVADRIANDIKQARALGVEVGVVIGGGNIFRGVAVASKGGDRVTGDHMGMLATVINSLALRTSLHKIGVDSVVLSAIAMPEICESFSQRQATAYMDEGKVVIFAGGTGNPFFTTDSAAALRAAEIEADALLKGTQVDGIYSADPKKDPGATRFDQLTHKEFLDRGLAVMDTAAVALARENNIPIIVYSIHENGGLADILQGKGRCTIVSDN
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGFB1_ONCMY
Sequence: MRAVCLMLTALLMLEYVCRSDTMSTCKSLDLELVKRKRIEAIRGQILSKLRLPKEPEIDQEGDTEEVPASLMSIYNSTVELSEEQVHTYIPSTQDAEEEAYFAKEVHKFNMKQSENTSKHQILFNMSEMRSVLGTDRLLSQAELRLLIKNHGLLDDSEQRLELYRGVGDKARYLKSHFVSKEWANRWVSFDVTQTLNEWLQGAGEEQGFQLKLPCDCGKPMEEFRFKISGMNKLRGNTETLAMKMPSKPHILLMSLPVERHSQLSSRKKRQTTTEEICSDKSESCCVRKLYIDFRKDLGWKWIHEPTGYFANYCIGPCTYIWNTENKYSQVLALYKHHNPGASAQPCCVPQVLEPLPIIYYVGRQHKVEQLSNMIVKSCRCS
What is the function of this protein?
Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity).  Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix.  At the same time, LAP chain interacts with 'milieu molecules', such as ltbp1, lrrc32/garp and lrrc33/nrros that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus.  TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1.  Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (tgfbr1 and tgfbr2), which transduce signal (By similarity).  While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'.  Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation.  Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (By similarity).  Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).
What are the official names of this protein?
Transforming growth factor beta-1 proprotein.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix. SUBCELLULAR LOCATION: [Transforming growth factor beta-1]: Secreted.
Protein: RLMKL_ECOUT
Sequence: MNSLFASTARGLEELLKTELENLGAVECQVVQGGVHFKGDTRLVYQSLMWSRLASRIMLPLGECKVYSDLDLYLGVQAINWTEMFNPGATFAVHFSGLNDTIRNSQYGAMKVKDAIVDAFTRKNLPRPNVDRDAPDIRVNVWLHKETASIALDLSGDGLHLRGYRDRAGMAPIKETLAAAIVMRSGWQPGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGRWGFSGWTQHDEAIWQEVKAEAQTRARKGLAEYSSHFFGSDSDARVIQRARTNARLAGIGELITFEVNDVAQLANPLPKGPYGTVLSNPPYGERLDSEPALIALHSLLGRIMKNQFGGWNLSLFSASPDLLSCLQLRADKQYKAKNGPLDCVQKNYHVAESTPDSKPVMAAEDYANRLRKNLKKFEKWARQEGIECYRLYDADLPEYNVAVDRYADWVVVQEYAPPKTIDAHKARQRLFDIIAATISVLGIAPNKLVLKTRERQKGKNQYQKLGEKGEFLEVTEYNAHLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKDFLNLFSYTGSATVHAGLGGARSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLIQADCLAWLREANEQFDLIFIDPPTFSNSKRMEDAFDVQRDHLALMKDLKRLLRAGGTIMFSNNKRGFRMDLDGLAKLGLKAQEITQKTLSQDFARNRQIHNCWLITAA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYG_ACET2
Sequence: MEVKKTMEKIVALAKNRGFIYPGSEIYGGLANSWDYGPLGVELKNNIKKAWWKKFVQENPYNVGVDCAILMNPQVWVASGHVGGFSDPLIDCKECKTRHRADKMIEEWNLKNNENVKVDGWSNEMLMNYIREKGVTCPECGGKNFTDIRKFNLMFKTFQGVTEDSKSEIYLRPETAQGIFVNFKNVQRTTRKKIPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFCEPGTDLEWFEYWKNFCFNWLLSLNIKKENLRMRDHSKEELSHYSNATTDIEYLFPFGWGELWGIADRTDFDLRQHAEHSKEDLSYFDPNTNRKYIPYCIEPSLGADRVALVFLCDAYDEEEVEEGDIRVVLRFHPAIAPVKIAVLPLSKKLGDEAYKIYEMLIKKYNCEYDETGSIGKRYRRQDEIGTPYCVTFDFDSLNDRCVTVRDRDSMQQVRIKIDELLSYFEGKFDF
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PME50_ARATH
Sequence: MGYISMSVVAFLVVFASPVVLATDTDPIPENRAQIPQWFKTNVKPYSQRKGTLDPALEAAEAARQIITVNQKGGANFKTLNEAIKSIPTGNKNRVIIKLAPGVYNEKVTIDIARPFITLLGQPGAETVLTYHGTAAQYGTVESATLIVWAEYFQAAHLTIKNTAPMPKPGSQGQALAMRINADKAAFYSCRFHGFQDTLCDDKGNHFFKDCYIEGTYDFIFGRGASLYLNTQLHAVGDGLRVITAQGRQSATEQNGYTFVHCKVTGTGTGIYLGRSWMSHPKVVYAFTEMTSVVNPSGWRENLNRGYDKTVFYGEYKCFGPGSHLEKRVPYTQDIDKNEVTPFLTLGYIKGSTWLLPPPKY
What is the function of this protein?
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
What are the official names of this protein?
Probable pectinesterase 50, PE 50, Pectin methylesterase 50, AtPME50.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: 3MGH_RICRO
Sequence: MNKLIPLPREFFARDTNVVSTELIGKTLYFQGKTAIITETESYIGQNDPACHAARGRTKRTDIMFGPAGFSYVYLIYGMYYCLNFVTEAKGFPAATLIRGVHVISPENLYLNGPGKLCKYLGINISHNKCDLINNNEFFVGDIGLKLPYSTTARIGITKGTDKLWRYVVTDITNLISQYNVQP
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: SYR_FRAAA
Sequence: MTPADLADAIVAAIGRAVADGDLDVTVPTTVTVERPKTAGHGDYASPVALQLAKAARRKPREVAEVLAGRLATQSGIASVDIAGPGFLNFTLAGDALGEIARTVVRAGESYGHAAKPRGVRVNLEFVSANPTGPVTLASARWAAVGDALARILTAAGFSVGGEYYVNDAGVQIERFGASVLAAAAGREIPAEGYHGAYVAEIAAAVLAGRPDLLDLPEDAALAVTTEEGLALMLTEIRSTLEGFGVHFDRWASERALHTAGALTKAIDDLRAQGHVYDADGAVWLRTTDFGDDKDRPLVKSDGQPTYFCADAAYYRDKRGRGFDQLIYLLGADHHGYVARLKAISACFGDDPATNLDVIIGQLVTLSRGGAPVKMSKRAGTFLTLHDLVDAVGVDAARYSLVRSSLDSSLDLDLDLVTRQTSDNPVFYVQYAHARISSLLRNAEALGLPTASETADVALLTHPREVDLLRGLGEFPRVIEAAASLRGPHRVARYLEELAGVYHRFYDACRVLPQGDEEAGPLTGARLLLVAATRVVLANGLGLLGVSAPERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOC_AGRFC
Sequence: MSEALNDLAAYVKEARGSLVVSADIAYGELTLNTTPENVIALLTFLRDDVQCGFVNIIDICGVDWPQREKRFDVVYHLLSPRQNLRVRIKLQVAEDEGVPSSTPVYMGAEWFEREAWDMYGIPFEGHKDLRRILTDYGFEGHPLRKDFPVTGFVEVRYDDVLKRVLYEPVELKQEFRNFDFLSPWEGTEYVLPGDEKAKQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NDK_DEIRA
Sequence: MERTFAMIKPDGVRRGLTPEILARIHNKGYRVVGLKQMMMPRETAEQHYGEHRERPFFGELVDFITGGPVVAIALEGENAIAGWRAMMGATNPANAAPGTIRADFATSTGENVTHGSDSPESAERELALFFGDGELLS
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_STREM
Sequence: MSKTIAINAGSSSLKWQLYQMPEEKVLAQGIIERIGLTDSISTVKYDGKKEEHILDIPDHTEAVKRLLNDLIHFGIIDTYDEITGVGHRIVAGGEYFKESVVVDDKVVEQVEELAALAPLHNPGAAAGIRAFRKILPDITSVCVFDTSFHTTMQKHTYLYPIPQKYYTDYKVRKYGAHGTSHKYVAEEAAKMLGRPLDELKLITAHVGNGVSITANYHGQSVDTSMGFTPLAGPMMGTRSGDIDPAIIPYLIAQDPELKDAADVVNMLNKQSGLGGVSGISSDMRDIEAGLQANNPDAVLAYNIFIDRIKKFIGQYFAVLNGADALVFTAGMGENAPLMRQDVVNGLSWFGMEIDPEKNVFGYRGDISTAASKVKVLVISTDEELCIARDVERLKKTVSS
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_ARCFO
Sequence: MTNIRKMHPLAKIINNSLIDLPAPSNISAWWNFGSLLAVCLALQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTLMETWNIGIILLFTIMATAFMGYVLPWGQMSFWGATVITNLLSAVPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFVASALVMVHLLFLHETGSNNPSGVSSDSDKIPFHPYYTIKDILGALLLILILMLLVMFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILTLAVIPLLHTSKQRGMMFRPISQFLFWLLVADLLTLTWIGGQPVEHPFIAIGQLASILYFTILLILMPIAGIIENYILKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PPR37_DANRE
Sequence: MNCEDQAVDLCKAIDLCNVSDNTISHPTPAEEILPRDGLQLMDGDQEEQDAAVLTRLKDVHLKDDALHTKNNGSIAVSADPVNGSAGDLQQSTVEEPLATKCSVGDVGDDGEMDIGVDLSLDENGVLEFEPTAQTQSEESASSCENSLISDTVIELHSQEPLEEHSVDVPSETVPAAATPVVEEAGIKHGLKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVEEILNAYRQACQKLNCKPIPKVLKQTQDLKDLTQRNECLDLKGEKLDYKSCESLEEIFKRVQFKLVDLEQTNLDEDGASALFDMIEYYESATHLNISNNKHIGTRGWQAAAHMMRKTNSLQYLDARNTPLLDHSAPFVARALRISSSLTVLHLENSGISGRPLMLLATALKMNMNLRELYLAENKLNGLQDSAQLGNLLKFNYNIQILDLRNNHILDSGLAYVCEGLKEQRKGLVTLVLWNNQLTHNGMGYLAAALPFTQSLETLNLGHNAVGNEGVHKLKDGLISNRSILRLGLASTKLSCEGAVAIAEFIAESPRLLRLDMRENEIKTGGLMALSLAFKVNTSLLRLDLDREPKKETVKSFIETQRALLADIQNGCKRNFILAREKEETEQKMRLSASMAEIATEDQTHEEEEEEEASPLKKIEEETTDALKDATQESSEVSENQEPKDQESTPQDDSDSDTEDEETPTNTSLTSTSPIPIPAAADTSKTIPSTPPIASPAVISGITVTEASIVTPSSPGRCISVSSPGRGHKIFMVTRVESPPEQQQTSIAMLKSIQPSAITDIKAPSQTQNSTQPTEKSHAEKTPDAQQEDSVSTSTPSLDANIDQTQLTESVSEEEQKKAETLNNEADINEDANTGAPLPNGLKPEFALFEFEGAKPASCIMEHVSVTAELSCGQDLEELLLDASLETSRDAP
What is the function of this protein?
May inhibit phosphatase activity of protein phosphatase 1 (PP1) complexes.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 37, Leucine-rich repeat-containing protein 68.
What is the protein family that this protein belongs to?
Belongs to the PPP1R37 family.
Protein: SWNT_METRA
Sequence: MAKLGTMPPQHAAKPVDEHAARLIPEDSVPIQTQKPFTTLSAIGIGYGVTNTAVGIPLILSTAMPMGGSPQVFWGFLAMAAVGLATATTLAELVSAMPHPGGQYIWVNALAPKRYRRGLSYTTAMISWVAAVATGSSGNLSVPLNAFSIVTLLQPDFVYRRWMGFAAFQAINVVTCFGACFEHALPKLSKAFLLFNVVSVGVIIVALFAMADARTSAKDFFTTVNTSGWPDGVAFIIGLNGANWCFSCLDVATHLAEEIPSPGTNIPKALLWTIFIASTSGLLVVLAVLVNLGPVDVSDYSGIGIFYRITGSKAAAIGLWIPVLILVLASVWSIQTWQSRLAWTISRESGFPLHRHFSKIFPAPFYTPIWSLVGSAVGTALFGCLYLASELAFNSLIATGILLQYISYSIPTVLVLWQGRRNFRHGQFWYPRLGLVANFIMLAWTVVAFVFYCFPANAQVRPSQMNYVSGVLVVIATFIAALWILYARKNYRVMEI
What is the function of this protein?
Transmembrane transporter; part of the gene cluster that mediates the biosynthesis of swainsonine, a cytotoxic fungal alkaloid and a potential cancer therapy drug (PubMed:28381497).  Does not mediate the secretion of SW and the exact role of swnT in SW biosynthesis remains to be determined (PubMed:32786262).
What are the official names of this protein?
Transmembrane transporter swnT, Swainsonine biosynthesis gene cluster protein T.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid/choline transporter (ACT) (TC 2.A.3.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CYB_MIRAN
Sequence: MANIRKTHPLAKIINNSFIDLPTPPNISAWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHMGRGLYYGSYTFTETWNVGIILLFTIMATAFMGYVLPWGQMSFWGATVITNLLSAVPYVGNDLVQWIWGGFSVDKATLTRFFALHFILPFVALALAAVHLLFLHETGSNNPSGIPSDSDKIPFHPYYTIKDILGALLLILTLMLLVLFSPDLLGDPDNYIPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILAIIPLLHTSSQRGMMFRPISQCLFWLLVADLLTLTWIGGQPVEHPYIIIGQLASILYFMILLVLMPITSIIENHILKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GRAN_GVCPM
Sequence: MGYNKSLRYSRHDGTSCVIDNHHLKSLGAVLNDVRRKKDRIREAEYEPIIDIADQYMVTEDPFRGPGKNVRITLFKEIRRVHPDTMKLVCNWSGKEFLRETWTRFISEEFPITTDQEIMDLWFELQLRPMHPNRCYKFTMQYALGAHPDYVAHDVIRQQDPYYVGPNNIERINLSKKGFAFPLTCLQSVYNDNFERFFDDVLWPYFYRPLVYVGTTSAEIEEIMIEVSLLFKIKEFAPDVPLFTGPAY
What is the function of this protein?
Component of the virus occlusion bodies, which are large proteinaceous structures, that protect the virus from the outside environment for extended periods until they are ingested by insect larvae.
What are the official names of this protein?
Granulin, Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the polyhedrin family.
Protein: KANK1_HUMAN
Sequence: MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGTSVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVCETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEAAVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD
What is the function of this protein?
Involved in the control of cytoskeleton formation by regulating actin polymerization.  Inhibits actin fiber formation and cell migration (PubMed:25961457).  Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457).  Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457).  Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2.  Inhibits neurite outgrowth.  Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing.  In the nucleus, is involved in beta-catenin-dependent activation of transcription.  Potential tumor suppressor for renal cell carcinoma.  Regulates Rac signaling pathways (PubMed:25961457).
What are the official names of this protein?
KN motif and ankyrin repeat domain-containing protein 1, Ankyrin repeat domain-containing protein 15, Kidney ankyrin repeat-containing protein.
What are the subcellular locations of this protein?
Cell projection, ruffle membrane. Cytoplasm. Nucleus. Note=Colocalizes with KIF21A in membrane ruffles (PubMed:19559006). Shuttles between the cytoplasm and nucleus (PubMed:16968744). SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus.
Protein: CODY_ALKCK
Sequence: MDLLTRTRKINEMLQKTSGQHVNFREMAMTLREAIGSNVFVVSRRGKLLGFSIEEEIENDRMKKMLDERQFPEEYTDGLFKIEDTSANIDVDSEYTAFPVENRDIFKNGLTTIVPIKGGGQRLGTLILSRLNRSFSDDDLILAEYGATVVGMEILHEKTQEIEEEARSKAVVQMAISSLSYSELEAVEHIFEELDGREGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKGTYIKVLNDKFLLELERMKED
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.