PharMolix/UniProtQA huggingface dataset:
Protein: HSPQ_SALPB
Sequence: MIASKFGIGQQVRHSLLGYLGVVVDIDPEYSLDEPSPDELAVNDELRAAPWYHVVMEDDDGQPVHTYLAEAQLRSEMRDEHPEQPSMDELARTIRKQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGCS_METMP
Sequence: MDFVSLVNTVNSFVWGPYMLVLLLGTGIFLTLRLGFMQIHTLPYALKLAFSKHQDETSEGDISHFQALMTALAATIGTGNIAGVATAYVLGGPGAIFWMWVTAFFGMATKYAEAVLAIKYRTVDDNGEMAGGPMYFLEKGLPDHGLGKILGVAFAFFGAFAAFGIGNMVQTNSVADAVASNFGVDPLITGFVLAIFTAAVILGGIKSIGKATGIIVPFMAVFYILAGLVILAMNIGYIIPAFGTIFSSAFNFSAGFGALIGTAIMWGVKRGVFSNEAGLGSAPIAAAAAKTDHPGRQALVSMTGTFLDTIVVCTITGLVLTIAGLKAFPGLTDLTGASLTAASFDALMPMGGLIVTIGLVFFAYSTVLGWSYYGEKCFEYLIGTKGIRLYRIAFVLVAFWGATASLPLVWNIADTLNGAMAIPNLIGLLLLSGVVVSETKAFNEIRKNEAKNA
What is the function of this protein?
Catalyzes the sodium-dependent uptake of extracellular D-alanine and L-alanine (PubMed:15659675, PubMed:30659158).  Can also transport glycine (PubMed:30659158).  Binds glycine and both enantiomers of alanine, while strictly excluding other amino acids (PubMed:30659158).
What are the official names of this protein?
Sodium/alanine symporter AgcS, Alanine permease, Alanine/glycine:cation symporter.
What is the protein family that this protein belongs to?
Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UCSE_ACRSP
Sequence: MATRTADKLEKKLVVVVGGTSGLGFAVAQAAVDRKANVVVASSKQASVDDALSRLQAGLASDDDVARVRGLTLDLAAANVEEQIVALYDFASKNGQQKIDHIAVTAGDSLYPKALDQVKAEDFINASQVRVIGALLLAKHAAKYLAKSAASSFTLTSGVRDVRPAANFAPVAPVSAAVKSLAKTLAHDLAPIRVNSISPGAVRTEFFTKIAGEHADAVLQGLAEQTLTKSNGVAEDIAEIYLVVMTSAYIDGADLVADGGSLIA
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of UCS1025A, a member of the pyrrolizidinone family that acts as a strong telomerase inhibitor and displays potent antibacterial and antitumor properties (PubMed:29373009).  These compounds share a hemiaminal-containing pyrrolizidinone core fused with a gamma-lactone, giving a furopyrrolizidine that is connected to a decalin fragment (PubMed:29373009).  The polyketide synthase module (PKS) of the PKS-NRPS ucsA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:29373009).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with a 2S,3S-methylproline derived from L-isoleucine by the 2-oxoglutarate-dependent dioxygenase ucsF which converts L-isoleucine to (4S,5S)-4-methylpyrroline-5-carboxylate that is further converted to 2S,3S-methylproline by the pyrroline-5-carboxylate reductase ucsG (PubMed:29373009).  Reductive release of the completed aminoacyl polyketide from the assembly line can form the 3-pyrrolin-2-one structure via an intramolecular Knoevenagel reaction (PubMed:29373009).  Because ucsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase ucsL (PubMed:29373009).  This keto acyclic precursor is the substrate of the Diels-Alderase ucsH, that catalyzes the Diels-Alder cycloaddition (PubMed:29373009).  Oxidation of the 3S-methyl group to a carboxylate by the cytochrome P450 monooxygenase ucsK allows an oxa-Michael cyclization that might involve the reductase/dehydrogenase ucsI and which furnishes the furopyrrolizidine (PubMed:29373009).  The oxidase ucsJ likely plays a critical role in stereoselective reduction of the C5-C6 double bond to afford the required R-configured carboxylate group (Probable).  Further enolization and oxidation at C5 by an unidentified enzyme affords the last intermediate that can undergo oxa-Michael cyclization to yield UCS1025A (Probable).
What are the official names of this protein?
Short-chain dehydrogenase/reductase ucsE, UCS1025A pyrrolizidinone biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL33_PROM9
Sequence: MAKKGTRVVVTLECTEARTSTDPKRSNGVSRYTTEKNRRNTTERLELKKFNPHLNRMTIHKEIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: MURG_NEIM0
Sequence: MGGKTFMLMAGGTGGHIFPALAVADSLRARGHHVIWLGSKDSMEERIVPQYGIRLETLAIKGVRGNGIKRKLMLPFTLYQTVREAQRIIRKHRVECVIGFGGFVTFPGGLAAKLLGVPIVIHEQNAVAGLSNRHLSRWAKRVLYAFPKAFSHEGGLVGNPVRADISNLPVPAERFQGREGRLKILVVGGSLGADVLNKTVPQALALLPDNARPQMYHQSGRGKLGSLQADYDALGVQAECVEFITDMVSAYRDADLVICRAGALTIAELTAAGLGALLVPYPHAVDDHQTANARFMVQAEAGLLLPQTQLTAEKLAEILGSLNREKCLKWAENARTLALPHSADDVAEAAIACAA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MDH2_BURVG
Sequence: MAKPAKRVAVTGAAGQIAYSLLFRIANGDLLGKDQPVILQLLDLPQAQAAVKGVVMELEDCAFPLLAGVVITDDPKVAFKDADVALLVGARPRSKGMERKDLLSANAEIFTVQGAALNEVASRDVKVLVVGNPANTNAYIAMKSAPDLPKKNFTAMLRLDHNRALSQLAAKTGKPVASIEKLAVWGNHSPTMYPDFRFATAEGESMLKLVNDDVWNRETFIPTVGKRGAAIIEARGLSSAASAANAAIDHVRDWVLGTNGKWVTMGIPSDGSYGIPEDIIYGVPVTCENGEYKRVEGLEIDAFSREKMDGTLAELLEERDGVAHLLKN
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: SYDND_BRUMB
Sequence: MHRYRSHTCAALRKTDVGSNVRLSGWVHRVRDHGGILFIDLRDHYGITQIVADPDSPAFKVAETVRGEWVIRVDGEVKARADDAVNTNLPTGEVEIFATEIEVLSPAKELPLPVFGEPDYPEDIRLKYRFLDLRRETLHKNIMSRTKIIAAMRRRMTEIGFNEFSTPILTASSPEGARDFLVPSRIHPGKFYALPQAPQQYKQLLMVAGFDRYFQIAPCFRDEDPRADRLPGEFYQLDLEMSFVTQEEVWETMEPVMRGIFEEFAEGKPVTKVFRRIAYDDAIRTYGSDKPDLRNPIEMQAVTDHFAGSGFKVFANMIANDAKVEVWAIPAKTGGSRAFCDRMNSWAQSEGQPGLGYIFWRKEGDKLEGAGPIAKNIGEERTEAIRKQMGLEDGDACFFVAGLPSKFYKFAGDARTRAGEELNLVDRDRFELAWIIDFPFYEWDEDNKKIDFAHNPFSMPQGGMDALENMDPLEIKAYQYDLVCNGFEIASGSIRNQLPEVMVKAFEKVGLSQQDVEERFGGLYRAFQYGAPPHGGMAAGIDRVIMLLVGAKNLREISLFPMNQQALDLLMGAPSEVSPAQLRDLHVRLAPVQKS
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_RICAE
Sequence: MEIILIKPVRKLGKIGDILKVADGFGRNYLLPQKLAIRATEPNKELIVKQKHEFEAKDKQIREEVEKINALIKDQQLVFIRQTSNDGKLFGSVTNKEVADKLSENISYNISHSNIILDKQIKSTGIYTVEIRLHAELNAIVTVIVARSESEAQDYLREQKTETSEDLAESA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: Y4052_ARATH
Sequence: MVVVTKKTMKIQIHLLYSFLFLCFSTLTLSSEPRNPEVEALISIRNNLHDPHGALNNWDEFSVDPCSWAMITCSPDNLVIGLGAPSQSLSGGLSESIGNLTNLRQVSLQNNNISGKIPPELGFLPKLQTLDLSNNRFSGDIPVSIDQLSSLQYLRLNNNSLSGPFPASLSQIPHLSFLDLSYNNLSGPVPKFPARTFNVAGNPLICRSNPPEICSGSINASPLSVSLSSSSGRRSNRLAIALSVSLGSVVILVLALGSFCWYRKKQRRLLILNLNDKQEEGLQGLGNLRSFTFRELHVYTDGFSSKNILGAGGFGNVYRGKLGDGTMVAVKRLKDINGTSGDSQFRMELEMISLAVHKNLLRLIGYCATSGERLLVYPYMPNGSVASKLKSKPALDWNMRKRIAIGAARGLLYLHEQCDPKIIHRDVKAANILLDECFEAVVGDFGLAKLLNHADSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGLRALEFGKTVSQKGAMLEWVRKLHEEMKVEELLDRELGTNYDKIEVGEMLQVALLCTQYLPAHRPKMSEVVLMLEGDGLAERWAASHNHSHFYHANISFKTISSLSTTSVSRLDAHCNDPTYQMFGSSAFDDDDDHQPLDSFAMELSGPR
What are the official names of this protein?
Probable LRR receptor-like serine/threonine-protein kinase At4g30520.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ECP_PANTR
Sequence: MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRVINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHQSRFRVPLLHCDLINPGAQNISNCRYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDATI
What is the function of this protein?
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity.  Possesses a wide variety of biological activities.  Exhibits antibacterial activity (By similarity).
What are the official names of this protein?
Eosinophil cationic protein, ECP, Ribonuclease 3, RNase 3.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
Protein: PDUE_CITFR
Sequence: MNTDAIESMVRDVLSRMNSLQGESATPVAASSSAHTAKVTDYPLANKHPEWVKTATNKTLDDFTLENVLSNKVTAQDMRITPETLRLQAEIAKDAGRDRLAMNFERAAELTAVPDDRILEIYNALRPYRSTKDELMAIADDLENRYQAKICAAFVREAAALYVERKKLKGDD
What is the function of this protein?
The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
What are the official names of this protein?
Propanediol dehydratase small subunit, Diol dehydratase small subunit, DDH small subunit, Propanediol utilization protein PduE.
What is the protein family that this protein belongs to?
Belongs to the diol/glycerol dehydratase small subunit family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: KAD_SHESM
Sequence: MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQDDCVKGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDEEATVRKRLGIYHEQTKPLVEYYGKVAAAGNTQYHKFDGTQSVAAVSAQLASVLK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_ANOFW
Sequence: MKQYLQLLEDILQNGVYKDDRTGTGTLSVFGRQLRFDLREGFPLLTTKKLHIRSIIHELLWFLSGDTNIRYLKENGVTIWDEWADEKGDLGPVYGAQWRSWRGADGRTIDQISEVIEQIKTNPNSRRLLVSAWNVAELDHMKLPPCHYAFQFYVENGTLSCMWQQRSVDTFLGLPFNIASYALLTYMVAQQCDLQPKELIFTGGDVHLYMNHIEQAKLQLTREPRPLPKLIIKRKPASIFEYRFEDFEIVDYDPHPHIKADVSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN821_MOUSE
Sequence: MSRRKQTNPNKVHWDQVFAGLEEQARQAMMKTDFPGDLGSQRQAIQQLRDQDSSSSDSEGDEEETTQDEVSSHTSEEDGGVVKVEKELETAEAPVSSGDALAEREVTENLNSDPLLQLCQCPLCQLDCGSREQLIAHVYQHTAAVVSAKSYMCPVCGRALSSPGSLGRHLLIHSEDQRSNCAVCGARFTSHATFNSEKLPQVLNMESVPQVHSEGPSSAEGKDIACSPPVYPAGILLVCNNCAAYRKLLETQTPSVRKWALRRQNEPLEVRLQRLERERTAKKSRRDNETPEEREVRRMRDREAKRLQRMQETDEQRARRLQRDREAMRLKRANETPEKRQARLIREREAKRLKRRLEKMDMMLRAQFGQDPSAMAALAAEMNFFQLPVSGVELDSQLLGKMAFEEQNNSSLH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 821.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYV_EHRRG
Sequence: MIMQSLFSNKYKFKDTEEKLNAYWDKIKLYKWKNLQGKQFIIDTPPPTISGQLHIGHVFSYCHTDFIARYQRMLGKDVLYPIGFDDNGLPTERLVEKIKKVRAADIDRKEFKALCNEVSAKFRMEFKILFQSLGISYDWDLEYHTISEEIQKLSQMSFIALYNMGKIYRKLQPIFWDCADRTAIARVEVEEKEMSSFMSTIAFSTEAGERINIATTRPELMPACVALFFNPLDIRYQHLQGQYAIVPIFGNKVPILSDEQVKIDKGTGLVMCCTFGDELDVYWWNKHNLNTQIIISKSGTLDLKHNIAETDTLSGKLHGVSIVEARKLVLETLSKCNLLIKKEEILHNVKCAERSGMPIEILLSNQWFIKVVEVKHELLEQVRKINWYPQSMRKQIEMWIDGLNWDWCISRQRYFGIPFPVWYSKRDNEEIIIPDVNELPIDPTETLPQGYSKEEVEADVDVMDTWATSSLSPQFNSIHTGINSIPLVPASLRAQSHEIIRSWAFYTILQAYYHHNSIPWENIMVSGWCLAADKSKMSKSKGNALIPNQLLQEYGADVIRYWAANSRLGSDTVFSDEVLQLGKRLVTKLWNASKFVSMFVSQCQIPDLNYVTETMDKWVLTKLYKVIVKATESFDVFEYCVALDYIESFFWKDFCDNYLELVKKRAYGESVTSKENLSAVNTLSFVLTTLLKMLAPFMPYITEEIYSTLYNNGSIHDHDNWPIVNTSLCNEMDEQLGEDFIEILNQVRKIKANAQLSVKCKIYKLIINSENYDFPTSWENDLKAVCNAEHIVRDKRTSYYDDKFLVSVQFAS
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUMP4_ARATH
Sequence: MGVKSFVEGGIASVIAGCSTHPLDLIKVRLQLHGEAPSTTTVTLLRPALAFPNSSPAAFLETTSSVPKVGPISLGINIVKSEGAAALFSGVSATLLRQTLYSTTRMGLYEVLKNKWTDPESGKLNLSRKIGAGLVAGGIGAAVGNPADVAMVRMQADGRLPLAQRRNYAGVGDAIRSMVKGEGVTSLWRGSALTINRAMIVTAAQLASYDQFKEGILENGVMNDGLGTHVVASFAAGFVASVASNPVDVIKTRVMNMKVGAYDGAWDCAVKTVKAEGAMALYKGFVPTVCRQGPFTVVLFVTLEQVRKLLRDF
What is the function of this protein?
PUMPS are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation.  This leads to a decrease in the efficiency of oxidative phosphorylation and an increase in heat production.  May be involved in protecting plant cells against oxidative stress damage (By similarity).  Recombinant PUMP4, reconstituted into liposomes, transports a wide range of dicarboxylic acids including malate, oxaloacetate and succinate as well as phosphate, sulfate and thiosulfate.  However, it is unknown if these transports are of any biological significance in vivo.
What are the official names of this protein?
Mitochondrial uncoupling protein 4, AtPUMP4, Mitochondrial dicarboxylate carrier 2.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PYRC_LISMO
Sequence: MYVLKNGQVLNASGKLESKDVLIQNGKVNLIADSIEVTSGEEFDATGKLITPGFIDVHVHLREPGGEHKETILTGTKAAARGGYTTICSMPNTKPVPDSKEVMESIQAKIKETAKVRVLPYASITTSLGTDELVDFEALKEAGAFAFTDDGVGVQLAGTMYEAMKRAAALDMAIVAHCEDNSLIYGGVVHDGIFAEKEGLKGIPNIAESVQIARDVLLAEAAGCHYHVCHISTKESVRVVRDAKRAGIRVTAEVSPHHLILDEEAIPGNDGNWKMNPPLRSKEDRAALLEGLLDGTIDFIATDHAPHAAEEKNVPMEQAAFGIVGLETAFPLLYTHFVKTNEWTLKQLIDWMTVKPAECFKLPYGKLEEGSVADIVVLDLEKEANIDPDTFYSKGKNTPFVGETCIGWPVATFAEGTLVYNEGEIK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: EAF1_ASPFU
Sequence: MLRDELLRSKNDEIARCLLSRKRKLSELYFATVGFAGATENAPTNALYHQKEQTFLDANDLTKGRYFNEATLPPFPDFAALIPRPEEQHSSLEITEPVVQTDDVSSVIAPKAEGAVRGIAPSFQQQEGQTAQVIEQRLVEDSLKKDDARIHQQPALATTSEIPQVANSPTTPAQPDQLPQKASFAVPDTPPTSTSHESVDASVSPALKGLPPSEVAPPRAVSNQLPSAQRKPESRPSLVLAQPSEDQPLSPASSAGPYSNNTPAPVAVSPDTSPAEEVTEGADEVALSPKRVGPVQLQPGLVPSTPDEQLQLEAAQSLQQNALASKSIGDVTTASSLSNEVIKEDVGPTPSAAADSSKETQDQTSTSVEAPEPKRPDGVVVAPEESQPPAQSIQEETQSQVGAEVKVVASTTPAGKKPTAAAVLPAQPERMTTRVSSGAIRHKSVSEILGETPKPSAVQPEKAHAIEKPADMVRAPASASPESAAKMRLKDRKAREKERSKLSTVVFPKQQQQQQQQQEKDDSLDIVRQYAGELARLNEEQDYLFTLFQNKAYAPPRGTNLSTLLASAHKTLTTSNHLLEYQEQMDCRTLRRIYALQNANRWPLRQLKRSVEPPRQGTHWDVLLDHMKWMRTDYREERKWKIAAAKSCADWCAEYVNSDPEHRALLRVPCRIPSKFEKKEAHASSMISPPEETTEEMLVVSQPTPDLIPSAEDESVSDGFNDEIRHDIRDTVAPAAIFSLGSDEFTFSLDMTPAAQKLLDELPIYTPVKIAPGANVPMFEQPPDSAWKTELLPVSKYASGRIKFHETESPRKRSRYDYSQYDSNPEHGMLDLPPEQTNVALFRPENKPIRDRIHPGHSFRPPTEYPMPSVGFFESRQSSQWTYAEDDELRRLVKEYSYNWSLISSCLTPSSQFTSGAERRTPWECFERWVGLEGLPADMSKTQYFRAYHQRIETAQRTVLAQQQAAQQQQQQQQQQQQQGGNNSGQAQPPIRRRTTQPVRVDRRRSSKHLALLDAMRKLAKKRETMLQKQQHASHLASLRKVNDANQPKPPISSPAEFSRLKYDRELKLQERQEQYRQQMIAQQRANLAAQRAGQIPSQQPMMNAPPGRTPNGIPHNPGTPGIPGATPNGMHNGMPNALPNGIPPGMGVSQGRPHMQGVPAGGPPMNGPIPPNPMAMKMMPQTGMPQGPGGRPGMPMQTSPDNTRVMREANRLQEQQRILQSRQQQPQPPQHQQPQAQQAQQQFHNQQQFGPQGSHSPNMNLPNVNGTPNNPAMMAAIQAGSGMQSPSLHNAMPQGVSTPSPRMGQPNLLSGGVVPTISSIQSQIQRSNPNMPPEQVNKLATDRLHQYQQQRMSQVAMNAAAGNMASVQANYQVPHDGNFQSPQPGMNGTPGMQVPQSQGFSPMMRVPQPAQQNRMGVGNSPAMNVALPQQSRSATPQTQRSGSAQAGPVPGSSKSPHPPQAQIPSG
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
Chromatin modification-related protein eaf1, Esa1-associated factor 1, Vacuolar import and degradation protein 21.
What is the protein family that this protein belongs to?
Belongs to the EAF1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MUTS_BRUA4
Sequence: METTANEHGSEAEENTAEAAPVRLTPMMEQYIEIKAANVDSLLFYRMGDFYELFFDDAVEASAALGITLTKRGKHLGEDIPMCGVPVHAADDYLQKLIAKGYRVAVCEQVEDPAEAKKRGSKSVVKRDVIRLVTPGTLTEEKLLDPSEANFLMAMGRTRGDGALALAWIDISTGTFRVAETTPDRLFADVMRVDPRELVVADSAFHDEELRPVFDLVGKAVTPQPATLFDSAAAETRIQRYFNVATLDGFGQFSRPELSAISGAIAYIEKTQISERPPLMRPEREHEGGTLFIDPATRASLELARTMSGNRDGSLLKAVDRTVTGGGARLLAERLTAPLTNPKEIALRLDSVSWFLSEQSLCEAMRAELKGVPDMPRGLSRLAVGRGGPRDLGSLARGFEAAHVIASLLESALLPDELAHARDAVSAMPAIFTAHLDRALADELPLLKRDGGFVRGGYNSELDEMRALRDQSRRVIAGLQANYIEETGIKSLKIKHNNVLGYFIEVTANNAGAMTDTDEAKSRFIHRQTMANAMRFTTTELAELESKIANAADRALSIELAVFEELTAEAVSHADSIRAAASALAVFDVSASLAVLAEEQGYCRPQVDDSLSFNIVAGRHPVVEQALRRQAANPFVANDCDLSPQADGGNGAIWLLTGPNMGGKSTFLRQNALIAIMAQMGSFVPAGSAKIGVVDRLFSRVGASDDLARGRSTFMVEMVETAAILNQAGERSLVILDEIGRGTATFDGLSIAWAAVEYLHEKNRCRALFATHFHEMTALSEKLERLSNVTMRVKEWDNDVVFLHEVAKGAADRSYGVQVARLAGLPEAVVNRARDVLHQLEAGETSGKADKLIDDLPLFSVVLQQEKPKLQVQGKDSDLTKAVSAISPDELTPREALDLIYKLKELAGRA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: H4_BLAAD
Sequence: MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISALIYEETRSVLKTFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: UCN2_RAT
Sequence: MTRWALVVFMVLMLDRVPGTPIPTFQLLPQNYPETTPSSVSSESPSDTTTGPSASWSNSKASPYLDTRVILSLDVPIGLLRILLEQARNKAARNQAATNAQILARVGRR
What is the function of this protein?
Suppresses food intake, delays gastric emptying and decreases heat-induced edema.  Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).
What are the official names of this protein?
Urocortin-2, Urocortin II, Ucn II.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPB_FRATF
Sequence: MNNIYQKDLGLQQYTKVFEDMLEFTSTRTPETNDEIWLVEHPAVFTQGKHGKPEHILNSHNIPIVATDRGGQVTYHGPGQAVIYFLLDIKRNKLGAKKLVTTVEQACINMLDKYYNLKAHIIDGAHGIYINNQKIASLGLRIKQGKSYHGIAINTNMDLTPFSYINPCGYSGLKMCQLANFYQEADIKKVQQQYTAEFVTLLNNSI
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_LACPL
Sequence: MIKMRDIIREGNHTLRAEAKQVKFPLSEADQKLANDMMEYLENSQDPELAKKYGLRAGVGLAAPQVDVSEQMAAVLVPSENEDDEPVFKDVIINPVIISHSVQPGALTEGEGCLSVDRDIAGYVIRHDRITLRYYNMAGEEKKIRLKNYPAIVCQHEIDHLHGILFYDHINGDNPFAADDDLVLIS
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: LCE2D_HUMAN
Sequence: MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCPPQCPAPCSPAVSSCCGPSSGSCCGPSSGGCCSSGGGGCCLSHHRPRLFHRRRHQSPDCCESEPSGASGCCHSSGGCC
What is the function of this protein?
Precursors of the cornified envelope of the stratum corneum.
What are the official names of this protein?
Late cornified envelope protein 2D, Late envelope protein 12, Small proline-rich-like epidermal differentiation complex protein 1A.
What is the protein family that this protein belongs to?
Belongs to the LCE family.