PharMolix/UniProtQA huggingface dataset:
Protein: UBXN6_MOUSE
Sequence: MKKFFQEIKADIKFKSAGPGQKLTDSAGEKTTKGKSPQLALRQPRQGPTDEAQMAAAAALARLEQKQPRARGPTSQDSIRNQVRKELQAEATSSNNPGAPGTNSVPEPKEEISPHLAVPGVFFICPLTGVTLRRDQRDAHIKQAILSHFSTDPVAASIMKIHTFNRDRDRVKLGVDTIAKYLDNIHLHPEEEKYQKIKLQNKVFQERINCLEGSHEFFEAIGFKKVTLPVPDQEGQEEFYVLGEDARAQPQNLARHKQQLLDAEPVRATLDRQLRVFRPSALASHFELPSDFFSLTAEEVKREQRLRTEAVERLSSLRTKAMREKEEQRELRKYTYALVRVRLPDGCLLQGTFYAREKLSALFRFVREALQNDWLPFELRASGGQKLEENEALALNECGLVPSALLTFSWDASVLEDIRAAGAEPAKSVLRPELLAAIEQLS
What is the function of this protein?
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes.  As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation.  It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins.  Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.
What are the official names of this protein?
UBX domain-containing protein 6, UBX domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Note=Localizes at the centrosome both in interphase and during mitosis. May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP. Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains.
Protein: TRMFO_DESVV
Sequence: MTTITTAAIIGAGLAGCECALRLARAGVRVTLFEMKPAAFSPAHSNPDLGELVCSNSLRSDDIASGVGLLKQEMRELGSIVMEAADATRVPAGKALAVDRDLFARHITAVIEAEPGITLERREVASLDDPALASADVVVVAAGPLASAGLSDSLAAMVGGQLYFYDAIAPIIAAESIDLSIAFSGSRYGEPGEEGDYLNCPMNRDEYDAFYEALLAAEKVPSRDFEKELHFEGCMPIEALAERGPRTLVFGPFKPVGFTDPRTGTRPYAIIQLRAENRNKTAFNIVGCQTKLKYAEQERVFRMIPGLAGAEFVRHGSVHRNTYVNAPRVLADDLSLRADKRVFLAGQITGVEGYVESAACGMWLGMVLAARIQGRELPTPPPQTALGALLMHLRTPVKNFQPSNANFGLMPELGLKVKKRERKPLYSARAREHFVRWLAEAGVTPVIEPLLPTAPDAADATGAIDTTGATGAAREETAPTEA
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_TAEAS
Sequence: MGIDISHRNKRKVVRRNPKSGDVYLRLMVKLYKFLARRTHSKFNNIVKRRLFMSRINRAPLSLSRLTRQMKKPGREGKIAVVIGTVTNDIRMREVPKLTVCALRVTAGARTRILKAGGKVMTVDQLALKAPLGKGTVLLQGPRKAREACRHFGPAPGVPGSHTKPYVISKSRERTNAHRA
What are the official names of this protein?
60S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL18 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_RHIME
Sequence: MRIGLFAVGRLKAGPEKDLAGRYLDRFAKAGPAVGLELARVVETAESRAANAETRKREEAGQLEKALADGSLLVLLDERGKALDSEAFARLLGTLRDSGKRDLMIAIGGADGLDPALHARADAVLNLGKMTWPHQLVRILIAEQLYRAVTILSGHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_PSEA7
Sequence: MFVTLIKPLARLHPRAWDFVQLVRLDRPIGIYLLLWPTLWSLWIAAGGVPELKNLLIFVLGVTLMRAAGCVINDFADRDFDGHVARTKARPLATGKISVREAWITFTILVALSFGLVLLTNAPTIWLSFGAVAVASLYPFMKRYTYYPQVVLGAAYSWGILMAFTAERGELPASAWLLFLANVLWTVAYDSYYAMTDREDDLKIGIKSTAILFGDADRLIIGSLQGLTLLLLALAGNRFELGACFYLGLVVAAACFAWEAWSTRDRDPQACFRAFLHNHWAGLAIFLGTVADYALR
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NQRA_ACTP7
Sequence: MITIKKGLDLPIAGTPAQVIHNGNTVNEVAMLGEEYVGMRPSMKVREGDVVKKGQVLFEDKKNPGVVFTAPASGTVVTINRGEKRVLQSVVIKVEGDEQITFTRYEAAQLASLSAEQVKQNLIESGLWTAFRTRPFSKVPALDAIPSSIFVNAMDTNPLAADPEVVLKEYETDFKDGLTVLTRLFNGQKPVYLCKDADSNIPLSPAIEGITIKSFSGVHPAGLVGTHIHFVDPVGATKQVWHLNYQDVIAIGKLFTTGELFTDRIISLAGPQVKNPRLVRTRLGANLSQLTANELNAGENRVISGSVLSGATAAGPVDYLGRYALQVSVLAEGREKELFGWIMPGSDKFSITRTVLGHFGKKLFNFTTAVHGGERAMVPIGAYERVMPLDIIPTLLLRDLAAGDTDSAQNLGCLELDEEDLALCTYVCPGKNNYGPMLRAALEKIEKEG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit A, Na(+)-NQR subunit A, Na(+)-translocating NQR subunit A, NQR complex subunit A, NQR-1 subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrA family.
Protein: LAC4_TRAVE
Sequence: MGRFSSLCALTAVIHSFGRVSAAIGPVTDLTISNADVSPDGFTRAAVLANGVFPGPLITGNKGDNFQINVIDNLSNETMLKSTSIHWHGFFQKGTNWADGAAFVNQCPIATGNSFLYDFTATDQAGTFWYHSHLSTQYCDGLRGPMVVYDPSDPHADLYDVDDETTIITLSDWYHTAASLGAAFPIGSDSTLINGLGRFAGGDSTDLAVITVEQGKRYRMRLLSLSCDPNYVFSIDGHNMTIIEADAVNHEPLTVDSIQIYAGQRYSFVLTADQDIDNYFIRALPSAGTTSFDGGINSAILRYSGASEVDPTTTETTSVLPLDEANLVPLDSPAAPGDPNIGGVDYALNLDFNFDGTNFFINDVSFVSPTVPVLLQILSGTTSAADLLPSGSLFALPSNSTIEISFPITATNAPGAPHPFHLHGHTFSIVRTAGSTDTNFVNPVRRDVVNTGTAGDNVTIRFTTDNPGPWFLHCHIDFHLEAGFAIVFSEDTADVSNTTTPSTAWEDLCPTYNALDSSDL
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products.
What are the official names of this protein?
Laccase-4, Benzenediol:oxygen oxidoreductase 4, Diphenol oxidase 4, Urishiol oxidase 4.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: COFH2_METMA
Sequence: MYTKKPTIPENVIERAYKGKCTKEDALLLLEGNPFELFELANDLRAIAAGDTVSYVVNRNIYITNKCVGNCGFCAYRTEKGYILSIEEILKKAGDARKAGAVEVCVQGGYTPEADMEFYLEVIESLKAEYPDLCLHALSPMEVNYAAETSGMSVEEALRRLKKSGLDSLTGTSAEILSDRVRKIICPSKISTQQWIDTVTAAHKAGISTNATIMYGHVETLKERLDHVFTIREIQKETGGFTELIPMSFLPYNNPVGEKMLASGKFSSTGLEDLQLIAISRVILHTYVKNIQATWVKLGKKLAQVALQCGANDLGGTLMEDQISTASGGSHGEYVSPAEFEWMIKGAGRVPVQRDTLYRKIESGFPGQEGLFPGYAKAGMGSKE
What is the function of this protein?
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
What are the official names of this protein?
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase 2, FO synthase subunit 2 2.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. CofH family.
Protein: H2B3_WHEAT
Sequence: MAPKAEKKPVAEKAEKTTAAKKTKAEKRPPASKEGGDKKGKKKSKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAGESAKLARYNKKPTITSREIQTSVRLVLPGELAKHAVSEGTKAVTKFTSA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.3, wcH2B-8.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: GLRX2_VACCW
Sequence: MKNVLIIFGKPYCSICENVSDAVEELKSEYDILHVDILSFFLKDGDSSMLGDVKRGTLIGNFAAHLSNYIVSIFKYNPQTKQMAFVDINKSLDFTKTDKSLVNLEILKSEIEKATYGVWPPVTE
What is the function of this protein?
Glutaredoxin necessary for virion morphogenesis and virus replication.  Functions as a thiol-disulfide transfer protein between membrane-associated OPG128/A2. 5 and substrates OPG095/L1 or OPG053/F9.  The complete pathway for formation of disulfide bonds in intracellular virion membrane proteins sequentially involves oxidation of OPG072/E10, OPG128/A2. 5 and OPG088/G4.  Exhibit thioltransferase and dehydroascorbate reductase activities in vitro.
What are the official names of this protein?
Glutaredoxin-2.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: RL13_DANRE
Sequence: MAPSRNGMILNPHFHKDWQKRVRTWFNQPARKIRRRKARQAKARRIAPRPVSGPLRPVVRCPTIRYHTKVRAGRGFTLEELKAAGINKKVARTIGISVDSRRRNRSTESLQANVQRLKEYRTKLIIFPRKAAKPKKGDSTEEELKMATQLTGPVMPIKKVHKKEKARVISEDEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  As part of the LSU, it is probably required for its formation and the maturation of rRNAs.
What are the official names of this protein?
60S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_SHEPC
Sequence: MSEGESKSTHFGYKTVEADKKAELVAGVFHSVAAKYDIMNDVMSFGIHRFWKRHTIEVSGARPGMKVLDLAGGTGDLTAKFSHLVGDKGEVVLADINDSMLKVGRTKLRDKGIVNNVSYVQANAEALPFPDNHFDIITIAFGLRNVTDKDAALRSMNRVLKPGGKLLVLEFSKPQHEIMRKVYDLYSFKVLPKMGELITKDADSYEYLAESIRMHPDQDTLKQMMVDAGFEQVDYTNMTDGIVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: LEUD_CORJK
Sequence: MEKFNTHTGVAAPLNRSNVDTDQIIPAVYLKRVTRTGFEDGLFAGWRKDPEFILNQEPYKNASVLVAGPDFGTGSSREHAVWALMDYGFRVVLSSRFADIFRGNSGKAGLLAAQMEQSDIELIWKLLEQQPGAEITVNLEDRTVTLGTHTFGFDVDDYTRWRLMEGLDDIGLTLRNEEAIEAFESQRASFKPRTIPAS
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: DFFB_RAT
Sequence: MCAVLPQPKCVKLRALHSSCKFGVAARSCQELLRKGCIRFQLPVPGSRLCMYEDGTEVTDDCFPSLPNDSELLLLTAGETWHGYVSDITRLLSVFNEPHAGVIQAARQLLSDEQAPLRQKLLADLLHHVSQNITAETREQDPSWFEGLESRFRNKSGYLRYSCESRIRGYLREVSAYISMVDAAAREEYLRVLSSMCHKLKSVQYNGSYFDRGAEASSRLCTPEGWFSCQGPFDLESCLSKHSINPYGNRESRILFSTWNLDHIIEKKRTVVPTLAEAIQDGREVNWEYFYSLLFTAENLKLVHIACHKKTTHKLQCDRSRIYRPQTGSRRKQPPRKQPPRKRPPRKRQ
What is the function of this protein?
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis.  Degrades naked DNA and induces apoptotic morphology.
What are the official names of this protein?
DNA fragmentation factor subunit beta, Caspase-activated deoxyribonuclease, CAD, Caspase-activated DNase, DNA fragmentation factor 40 kDa subunit, DFF-40.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: THIG_PERMH
Sequence: MFNEEQFFKDDKLVIGDREFTSRLIVGSGKYKDFEETAKATEASGAEIITVAVRRVNITDPDKPNLLDYIDTSKVMILPNTAGCYTAEEAVLTAKLAREALGHGFVKLEVIGDQKTLYPDMVETLKAAEILVKEGFTVLPYITDDPIMAKKFEDIGCAAVMPLAAPIGSGLGLQNPYNIIFIKEAVNVPVIVDAGIGTASDAAIVMELGVDGVLMNTAIAQAKDPIKMAVAMKYAVKAGRLAYLAGRIPKKMYASASSPIEGMIGR
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_XANCB
Sequence: MSEIQSLTAQALADVAAAHTPDQLETLRVALLGKNGSITAQLKQLGTLPADQRKAAGEAINLARDALTTALSERKQVLETAALDARLEGERIDVTLPGRRGERGGLHPVTRTLERIVEIFARLGYELSDGPEIEDDWHNFEALNFPPHHPARAMHDTFYFGDGRLLRTHTSGVQVRYMDTAVATKSGPPLRMIAAGKVYRSDSDQTHSPMFHQVEGLLVDEHSNFADLKGTLSEFVRAFFERDFEMRFRPSYFPFVEPGAEVDIAWQQPDGSTRWLEVLGCGMVHPNVLRSVGIDPERYTGFAFGLGVERFAMLRYGVNDLRAFFENDVRFLRQFA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRAP_STAEQ
Sequence: MYLYTSYGTYQFLNQIKLNHQERSLFQFSTNDSSIILEESEGKSILKHPSSYQVIDSTGEFNEHHFYSAIFVPTSEDHRQQLEKKLLHVDVPLSNFGGFKSYRLLKPTEGSTYKIYFGFANRTAYEDFKASDIFNENFSKDALSQYFGASGQHSSYFERYLYPIEDH
What is the function of this protein?
Contributes to virulence and biofilm formation.
What are the official names of this protein?
Signal transduction protein TRAP, Target of RNAIII-activating protein.
What is the protein family that this protein belongs to?
Belongs to the TRAP family.
What are the subcellular locations of this protein?
Membrane. Note=Membrane-associated.
Protein: Y875_PEDPA
Sequence: MEIPLINGFYFYVLRCADNTLYGGYTINLINRVERHNKGQGAKYTKARRPVQLIYFESFDNQHDAMSAEYQFKQRTRSSKIKFLKKNGISLTNLK
What are the official names of this protein?
UPF0213 protein PEPE_0875.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: VRAB_STAHJ
Sequence: MKEAVVIWAKRTPFGKYGGALRHLEPEALLLPLFQNLKQTFPEVMDQVDDVVLGNVVGNGGNVARKSLLEAGLNHRIPGITLDRQCGSGLESIIYACRMVQCEAGKVFIAGGVESTSRAPWKIKRPQSVYEMQLPQFFERASFAPEGQDPSMIEAAENVAQHYNISRNDQDLFAARSHRLVATHFNNGDINREIVPLTIKGALFDRDESLKPNLTEARLHRLRPILPNGTVTVGNSCMKNDGAGIALIMEKEMAVAMGIKWGMLYRDAVTTGVDPTLLGIGPVPAVSQLLKRQKLNIEDISAIELNEAFSSQVLASINELHLGLDKVNQWGGAIATGHPYSASGAALVARLLNLPNWQYGIATMGIGGGMGNAVLFEKWRQ
What are the official names of this protein?
Putative acetyl-CoA C-acetyltransferase VraB.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
Protein: RS4_ENDTX
Sequence: MSRYLGSVCKLCRREKEKLFLKGERCSSNCALNRKRGKNSPGQHGASKVKMSDYAKHLREKQKARRMYGLTEEQFSNYYKTAEKMKGSAGDNLLKLLELRLDNVVYRLGLASSKKMARQIVNHGNILVNEKKIDVPRYRLKIGDVITFPEKYKSNVIIKKLIEKMVSSIPAWLSFDKSRIAGTVVSEPLAGETSHPINSQLIVEYYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: FTSY_MYCGE
Sequence: MGFLSKLIAKLKPKKSVAKQLKEEVEKQSLFQTNNKTYYQGLKKSATTFAKTINELSKRYVNVDEQFKENLFEGLVLLDVGYHAANKICDAIIEQIKLNRITDFQLIKELIIDQIIVYYIQDKLFDTDLIVKPNFTNVYLFVGVNGVGKTTTLAKIADFFIKQNKRVLLVAGDTFRAGAIEQLNQWAKLLNCDIVLPNPKEQTPAVIFRGVKKGIDDKYDFVLCDTSGRLQNKLNLMNELQKIYQIIQKVSGSEPSETLLVLDGTVGQTGLSQAKVFNEFSKLTGIVLTKMDGSAKGGIILAIKDMFNLPVKLIGFGEKTSDLAIFDLEKYVLGLLNNLNLDNKEN
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
What are the official names of this protein?
Signal recognition particle receptor FtsY, SRP receptor.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. FtsY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: SALL_METJA
Sequence: MGIYMRDDILDIITLTTDFGTNEGYVGAMKGRILNILKKYNKDAKIIDISHEIKPFNIYHGAYVLLTAIPYFPPSVHVAVIDPTVGSERKSIVIETKSGYYLVGPDNGLFTYVAEKLGIKRIIKIDEERYKPSSTFHGRDVYAVVGAEILINNGYDGEELDEMVKIDETKKRVIHIDRFGNIITNIKKDEVTFKYYDTIMIKIRHKNGIEKIIKCKFVKSYFEEKNNFICLINSEGFLEISKFMDNASKLLNVDYLDEIEIIY
What are the official names of this protein?
Chlorinase MJ1651.
What is the protein family that this protein belongs to?
Belongs to the SAM hydrolase / SAM-dependent halogenase family.
Protein: GSK3A_HUMAN
Sequence: MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
What is the function of this protein?
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350).  Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350).  Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350).  Regulates glycogen metabolism in liver, but not in muscle (By similarity).  May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001).  In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088).  Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548).  May be involved in the regulation of replication in pancreatic beta-cells (By similarity).  Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity).  Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity).  Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899).  Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors.  Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B.  The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity).  Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075).
What are the official names of this protein?
Glycogen synthase kinase-3 alpha, GSK-3 alpha, Serine/threonine-protein kinase GSK3A.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Protein: ACP_PELPB
Sequence: MTAAEIKDKVYDIIVSKMGVNRDQIKMESKFSDDLGADSLDTVELIMELESEFGVQIPDEDAEKIGTVQQAIDYIVNKK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPLT_ARATH
Sequence: MVRTTASFGTSSSFVLRLGQTLFSSASLLFMCFNDDEDFYAYTTFCYLVTVMGLVTPWSVTLALMEAYSILVKKLPMQATVISVIVAGDFVLSFLSLGGACSTASVAVLLMDAGEKQCDRYKLSATMAFLSSFLSFASTFFNFCLLPSLMSH
What are the official names of this protein?
CASP-like protein 5C1, AtCASPL5C1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RGT1_YEAS7
Sequence: MNELNTVSTNSSDSTKNGGTSNSPDDMDSAAAASHAIKKRTKASRACDQCRKKKIKCDYKDEKGVCSNCQRNGDRCSFDRVPLKRGPSKGYTRSTSHPRTNEIQDHNNSRSYNTFDNSNNTLNNNTGNSGDNGINSNTVPSTPSRSNSVLLPPLTQYIPQVGGIPPSFQNPAIQSTMPAGNIGQQQFWKVPYHEFQHQRKGSIDSLQSDISVRTLNPNEQLSYNTVQQSPITNKHTNDSGNANGSVTGSGSASGSGGYWSFIRTSGLLAPTDDHNGEQTRRSSSIPSLLRNTSNSLLLGGQPQLPPPQQQSQPQAHQQKLQQGQNPYSYSQFSQQQPYNPSISSFGQFAANGFHSRQGSVASEAMSPSAPAMFTSTSTNPVNVAQQTQRPQGQQVPQFSSELDGNKRRQSAPVSVTLSTDRLNGNENNNGEINNNNGSNNSGSSKDTSQHSQESVTTPAALEASSPGSTPQRSTKKRRKSYVSKKTKPKRDSSISITSKDSAHPMTTSSTIAYGQISDVDLIDTYYEFIHVGFPIIPLNKTTLTSDLLLVNTQPISNIHEVNSYVILWFRNSLELLVRVALKQKPGGKFFDNIVGVALSPSNDNNKAGFTTATARDDAEKTRRDSHNEVQDTLEVQSVFIAALNECFQKIVDIHPKFRENNDQISPKIKVIYLSTFILLNYILAFVGYDNSFVLGMSVTIFNEFKLYKLLLFPEPDVNDVKAPVDEEANTGNGNTKTSEFEIGSESAGHMNPSNSPNSMDENISHYSVLFKRLYVLLSVFDSLQSCAFGGPKLLNISIQGSTERFFSNDLGSKWCLEQSQLRLKSVLQSLKLGELMSELTRNRISMNGNRKPGFDITNSSSLLSEYVETQPLSVAQLFCKLLIGKHNFINCLLSLYDSEAGVYSDLTLDLSSKIADSLCSLISIILQVLTLILRLNPTNSIDFNYRPPNPPANNPTVQEGPSAMGSSPVAGNLNAAPPSEGNPDFYKKLLGLKQDTGTILSDLCRGIISPFAIAILHEVYNITELVKQMPTSLISIMMTATTTQNTQDTKKSQDLVMKLSNSMNEVVQITSVLTMIKPFKIFEHELNKPIMSLTGGLSSTTRNDVMWPKSGQGLRESSVMKTLLDERRTSGTQPTTAPVAAEESRLENVALENFVSIGWKLLDDSELGWY
What is the function of this protein?
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose.  In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator.  In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription.  Binds the consensus binding site sequence 5'-CGGANNA-3', of which multiple copies are present in all HXT promoters regulated by RGT1 (By similarity).
What are the official names of this protein?
Glucose transport transcription regulator RGT1, Restores glucose transport protein 1.
What is the protein family that this protein belongs to?
Belongs to the EDS1/RGT1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.