PharMolix/UniProtQA huggingface dataset:
Protein: SLX8_YEAST
Sequence: MARRPDNQNPEGENLRIKRVRLESVRQNDEEEENEVSRTQNIVTDNRHDSPEAVVEIIGERALENTSEEDGDDDLSLFRALEEDPGSDHNTSNNDSGNHDRETMHTEEPEASSGNNITLTNNVEELHTMDVLSQTANTPSASPMLDAAPPTTKPGTNSKEQTVDLTADAIDLDAEEQQVLQISDDDFQEETKEAPKEYGAAKDYRCPICFEPPETALMTLCGHVFCCPCLFQMVNSSRTCRQFGHCALCRSKVYLKDVRLIILRKKQVKKKVKS
What is the function of this protein?
Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation (PubMed:11139495, PubMed:16325482, PubMed:18032921, PubMed:17669696, PubMed:17848550, PubMed:18499666, PubMed:18948542, PubMed:31015336).  The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins (PubMed:18032921).  The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin (PubMed:26960795).  The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis (PubMed:23785440).  The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins (PubMed:26906737).  During replication, the complex helps to prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2 (PubMed:16325482, PubMed:17591698).  The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination (PubMed:30479332).  It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57 (PubMed:18032921).  Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets (PubMed:31015336).
What are the official names of this protein?
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8, RING-type E3 ubiquitin transferase SLX8, Synthetic lethal of unknown function protein 8.
Protein: NACB_PHANO
Sequence: MDQAKLARMQASVRIGGKGTPRRKVKKVHKSSGTDDKKLQTALKKLNVQPIQAIEEVNMFKSDGNVIHFSAPKVHASVPSNTFAIYGNGEDKELTELVPGILNQLGPDSLASLRKLAESYQSMQKEKGEDGDKKDDDDEDDDDIPELVAGDNFESKTEVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: UVRC_MICAN
Sequence: MFGNNLNSTLIQDLDRLENRLREIPLEPGVYFLRDQNGEILYIGKSKKLRSRVRSYFRPSQPLSPRIALMVRQVTEIEFIVTDTEAESLALEANLIKQHQPHFNTLLKDDKKYPYICITWSETYPRIFITRKRRINNQKDRYYGPYVDTRLLRYTLHLIKRTFPLRQRPQPLFKDRPCLNYDIGRCPGVCQKLISPQDYRETLQKVAMIFQGRTGELLEKLATKMLAASENLDFEQAATIRDQIRGLQALNTDQKVSLPDDTVSRDAIALAKDEQHCCIQLFQVRSGRLVGRLGFFADSQSANEGEILQKVLEEHYLSVEGVEIPSEILLPCELPEGEVLAGWLREKKGRKVELTVPQRQSKADLLAMVEKNALYELEKTKRSADRDLQSLQDLAVILDLPALPHRIEGYDISHIQGSNAVASGVVFIDGVAANQHYRHYKIKNPEVKIGHSDDFASLAEVIRRRFRRYAENPDNIAESDDFPDLVMIDGGKGQLSAVVAVLGEMNLLEQVKVVSLAKQREEIFLPGESSPLETDKEQPGVQLLRRVRDEAHRFAVSFHRQQRMQKSRRSRLDEIPGLGFKRQKELLAHFHSLDYIREASLEQLQQVTGIGEQLAKEIYNYFHPR
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRY_PIG
Sequence: MVQSYASAMFRVLKADDYSPAAQQQNILALGKGSSLFPTDNHSSNDGRETRGSGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKWLGCKWKMLTEAEKRPFFEEAQRLQAVHRDKYPGYKYRPRRKGERAQNLLPAEAAVLCSQVRVEERMYPFTYTVAKAKCSGTESQLSHSQPMNITSSLLQQEDRCNWTGLCHSRVTSTGQIRADLPFHRGLQPGLSHIYFPY
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity).
Protein: CP20A_BOVIN
Sequence: MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTLDPFETMLKSLLRYQSDSGNVSENHMRKKLYENGVTNCLRSNFALLIKLSEELLDKWLSYPESQHVPLCQHMLGFAMKSVTQMVMGSTFEDEQEVIRFQKNHGTVWSEIGKGFLDGSLDKSTTRKKQYEDALMQLESILKKIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDTMIFSLASCMITAKLCTWAVCFLTTYEEIQKKLYEEIDQVLGKGPITSEKIEELRYCRQVLCETVRTAKLTPVSARLQDIEGKIDKFIIPRETLVLYALGVVLQDPGTWSSPYKFDPERFDDESVMKTFSLLGFSGTRECPELRFAYMVTAVLLSVLLRRLHLLSVEGQVIETKYELVTSSKEEAWITVSKRY
What are the official names of this protein?
Cytochrome P450 20A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YR746_MIMIV
Sequence: MAAAIVAVRINNSNSDEERERRHYQSRKIMDQTDDEVRIASQINNQYAPTKTGMGYMWYKLNCKYGVCIPNFKVIHAGYKLNQIYQSLEETVRFYIGRKQNIDLLIYQIKGIDPSLASYNIVTSSSNPCVFLKIRPKCDNLFWMKGNDSFIKIIYQKINFMAMYQEYRKQLIYLTKQDLTRLYIETFNKKSPKIFSMSRMRSRLLNYKLNKLLTE
What are the official names of this protein?
Uncharacterized protein R746.
Protein: GLSL_HUMAN
Sequence: MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV
What is the function of this protein?
Plays an important role in the regulation of glutamine catabolism.  Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate.  Increases cellular anti-oxidant function via NADH and glutathione production.  May play a role in preventing tumor proliferation.
What are the official names of this protein?
Glutaminase liver isoform, mitochondrial, GLS, L-glutaminase, L-glutamine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: MQO_PROM3
Sequence: MAVSDVAGSQSRYDAVLVGAGIMSATLAALLHELDPELRLLMVERLQAPGLESSAAENNAGTGHAANCELNYTPLQPDGSVATAKALAINTAFERSLEFWASLTEKGKLLPQQFLHLVPHISVVFGDADLAFLHQRFQQLSALPAFASMQWSTDAAELAEWMPLVMEGRANAESVAATCIKRGTDVDFGLLTRAYVKSLQASGALELSCGCEVVHLHRLGKHRWNLDLKHSSGSRSVQTPFVFLGAGGGALPLLQRSGIPEAAAYAGFPVSGQWLVCSEPGLTARHHAKVYGKAKVGAPPMSVPHLDSRWIDGCRSLLFGPYAGFSSKFLKQGSRLDLLRSVRRSNFRSMLEVGFKNFDLVTYLLSELQQSEKDRFETLKQFLPNAQLNDWKLSVAGQRVQIIKGTAEGGRLQMGTEVVSAEDGSLAALLGASPGASTAVTVMLEVLQRCWSERMASESWQERLQKLLPSYGHDPNSDPLLLMQMRIRSNELLSFT
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: PCKA_METNO
Sequence: MSDIGVFNAAVGADRAGLRNLKRVFWNLEAPGLYEQALQRGEAQLAVGGALVAETGIHTGRSPKDKFVVRDAETEAQVWWDNNGAISPEQFDRLHADFIAHAEGRELFAQDLYGGAEPAHRVRARVFTEFAWHSLFIRNLLIRPERDELATYEPDLTIIDLPSFKADPARHGVRSETMIACDFTRRIMLIGGTSYAGEMKKSVFTYLNYILPQAGVMPMHCSANVGGAGDSALFFGLSGTGKTTLSSDPARALLGDDEHGWSPKGIFNFEGGCYAKTIRLSREAEPEIYATTERFGTVMENVVIDPVTRLPDFDDASRTENTRCAYPLPFIPNASPTGRAGHPKNIVMLTCDAFGVLPPIAKLTGAEAMYHFLSGYTAKVAGTEKGLKGPEATFSTCFGAPFMPRHPSVYGNLLRDLIARHHVDCWLVNTGWTGGGVGTGRRMPIRVTRRLLTAALDGSLAKADFRRDPYFGFAVPTSVPGVEPHILYPVKTWQDKAAFAETAKKLVEMFQANFKRFEAHVDADVRAAEPTMSIAA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR11_PSINU
Sequence: MPKPIKRLSSHKKKRVIFKGIIQIKASFNNTIVTVTNSQGQVITWSSAGACGFKGTKRSTPFAAQIATENAIRTLISQGMKQAEVMISGPGPGRDTALRTIRKSGLVLHFVRDVTPLPHNGCRPPKRRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DSBL_ECOL6
Sequence: MSKLGISSLFKTILLTAALAVSFTASAFTEGTDYMVLEKPIPNADKTLIKVFSYACPFCYKYDKAVTGPVSEKVKDIVAFTPFHLETKGEYGKQASEVFAVLINKDKAAGISLFDANSQFKKAKFAYYAAYHDKKERWSDGKDPAAFIKTGLDAAGMSQADFEAALKEPAVQETLEKWKASYDVAKIQGVPAYVVNGKYLIYTKSIKSIDAMADLIRELASK
What is the function of this protein?
Involved in disulfide-bond formation.  Acts by transferring its disulfide bond to other proteins.  Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbL.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbL subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: GUNS_ACETH
Sequence: MVKSRKISILLAVAMLVSIMIPTTAFAGPTKAPTKDGTSYKDLFLELYGKIKDPKNGYFSPDEGIPYHSIETLIVEAPDYGHVTTSEAFSYYVWLEAMYGNLTGNWSGVETAWKVMEDWIIPDSTEQPGMSSYNPNSPATYADEYEDPSYYPSELKFDTVRVGSDPVHNDLVSAYGPNMYLMHWLMDVDNWYGFGTGTRATFINTFQRGEQESTWETIPHPSIEEFKYGGPNGFLDLFTKDRSYAKQWRYTNAPDAEGRAIQAVYWANKWAKEQGKGSAVASVVSKAAKMGDFLRNDMFDKYFMKIGAQDKTPATGYDSAHYLMAWYTAWGGGIGASWAWKIGCSHAHFGYQNPFQGWVSATQSDFAPKSSNGKRDWTTSYKRQLEFYQWLQSAEGGIAGGATNSWNGRYEKYPAGTSTFYGMAYVPHPVYADPGSNQWFGFQAWSMQRVMEYYLETGDSSVKNLIKKWVDWVMSEIKLYDDGTFAIPSDLEWSGQPDTWTGTYTGNPNLHVRVTSYGTDLGVAGSLANALATYAAATERWEGKLDTKARDMAAELVNRAWYNFYCSEGKGVVTEEARADYKRFFEQEVYVPAGWSGTMPNGDKIQPGIKFIDIRTKYRQDPYYDIVYQAYLRGEAPVLNYHRFWHEVDLAVAMGVLATYFPDMTYKVPGTPSTKLYGDVNDDGKVNSTDAVALKRYVLRSGISINTDNADLNEDGRVNSTDLGILKRYILKEIDTLPYKN
What is the function of this protein?
This enzyme catalyzes the exohydrolysis of 1,4-beta-glucosidic linkages in cellulose with a preference for amorphous or crystalline cellulose over carboxymethyl cellulose.
What are the official names of this protein?
Cellulose 1,4-beta-cellobiosidase (reducing end) CelS, Cellobiohydrolase CelS, Cellulase SS, Endo-1,4-beta-glucanase, Endoglucanase SS, EGSS, Exocellulase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 48 (cellulase L) family.
What are the subcellular locations of this protein?
Secreted.
Protein: DADA_PSESM
Sequence: MRVLVLGSGVIGTTSAYYLARAGFQVTVVDRQPAVGMETSFANAGQVSPGYASPWAAPGVPLKAIKWLLQRHSPLAIKATADIDQYLWMAQMLRNCTANRYAVNKERMVRLSEYSRDCLDELRIETGIAYEGRSLGTTQLFRTQAQLDNAAKDIAVLEQSGVPYELLDRAGIARVEPALAGVTGILSGALRLPNDQTGDCQLFTTRLAQMAVELGVEFRYGQNIERLEHAGDTVSGVWIDGVLETADRYVLALGSYSPQLLKPLGIKAPVYPLKGYSLTVPISNPAMAPTSTILDETYKVAITRFDNRIRVGGMAEIAGFDLSLNPRRRETLEMIVGDLYPQGGDLSQASFWTGLRPTTPDGTPIVGATPLRNLFLNTGHGTLGWTMACGSGRLLADLIARKRPQISAAGLDISRYGNPQENAQHVNPAPAHQ
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: BIP_YARLI
Sequence: MKFSMPSWGVVFYALLVCLLPFLSKAGVQADDVDSYGTVIGIDLGTTYSCVGVMKGGRVEILANDQGSRITPSYVAFTEDERLVGDAAKNQAANNPFNTIFDIKRLIGLKYKDESVQRDIKHFPYKVKNKDGKPVVVVETKGEKKTYTPEEISAMILTKMKDIAQDYLGKKVTHAVVTVPAYFNDAQRQATKDAGIIAGLNVLRIVNEPTAAAIAYGLDHTDDEKQIVVYDLGGGTFDVSLLSIESGVFEVLATAGDTHLGGEDFDYRVIKHFVKQYNKKHDVDITKNAKTIGKLKREVEKAKRTLSSQMSTRIEIESFFDGEDFSETLTRAKFEELNIDLFKRTLKPVEQVLKDSGVKKEDVHDIVLVGGSTRIPKVQELLEKFFDGKKASKGINPDEAVAYGAAVQAGVLSGEDGVEDIVLLDVNPLTLGIETTGGVMTKLINRNTNIPTKKSQIFSTAVDNQSTVLIQVFEGERTMSKDNNLLGKFELKGIPPAPRGVPQIEVTFELDANGILRVTAHDKGTGKSETITITNDKGRLSKDEIERMVEEAERFAEEDALIRETIEAKNSLENYAHSLRNQVADKSGLGGKISADDKEALNDAVTETLEWLEANSVSATKEDFEEKKEALSAIAYPITSKIYEGGEGGDESNDGGFYADDDEAPFHDEL
What is the function of this protein?
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.  Is required for secretory polypeptide translocation.  May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.
What are the official names of this protein?
Endoplasmic reticulum chaperone BiP, Immunoglobulin heavy chain-binding protein homolog, BiP.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: GGEE3_HUMAN
Sequence: MSEHVRTRSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENEGAPAVQGPDMEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP
What are the official names of this protein?
Putative G antigen family E member 3, Prostate-associated gene 2B protein, PAGE-2B.
What is the protein family that this protein belongs to?
Belongs to the GAGE family.
Protein: SYL_SHEB2
Sequence: MQEQYNPSEIEALVQKHWHDNKTFEVTEDANKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVVARFQRLQGKNVLQPIGWDSFGLPAENAAINNKTAPAPWTYENIEYMKNQLKLLGFGYDWSREIATCTPEYYRWEQWFFTKLYEKGLVYKKTASVNWCPNDETVLANEQVQDGCCWRCDTPVEQKEIPQWFIKITAYAEELLNDIDTLDGWPDQVKTMQRNWIGRSEGVEMTFGVAGHDKSFDIYTTRPDTLMGVTYVAIAAGHPLAEIAAHTNPELAAFIDECKNSTTSEAELATMEKRGVATGLFAIHPITGKQVPIWAANFVLMNYGTGAVMSVPGHDQRDFEFAKKYGLAIEAVIKPVDGDVDISEAAYTEKGVLFNSGEFDGLDFEAGFNAIANKLVAEGKGKRQVNYRLRDWGVSRQRYWGAPIPMVTLADGTVIPTPADQLPVLLPEDVVMDGIQSPIKADKEWAKTQVNGQDALRETDTFDTFMESSWYYARYCSPHADEMLDPAKANYWLPVDQYIGGIEHACMHLLYFRFFHKLLRDAGLVNSNEPAKQLLTQGMVLADAFYYINEKGARVWVSPLDVATTEKDDKGRITKAIDKDGNELVYTGMSKMSKSKNNGIDPQVMVEKYGADTVRLFMMFASPPELTLEWQESGVEGAHRFIKRLWKLANEHVNQDNSEALDVSTLTSDQKALRREVHKTIAKVTDDIGRRQMFNTAVAAVMELMNHLQKAPQTTGQDNAIIGEALSAIVRLLYPIIPHVSFNLWNELGNASNIEDSQWPVVDEAALVEDSKLIVVQVNGKVRAKITVAADADKESVEALGMIDEHVIKYLDGLTVRKVIYVPGKLLSIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_BACAC
Sequence: MTAIRYEFIKTCKQTGARLGRVHTPHGSFDTPTFMPVGTLATVKTMSPEELKAMDSGIILSNTYHLWLRPGHEIIREAGGLHKFMNWDRAILTDSGGFQVFSLSDFRRIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPFPATFEYMKKSVERTSRWAERCLKAHERPQDQGLFGIVQGGEFEELRRQSAKDLVSMDFPGYAVGGLSVGEPKDIMNRVLEFTTPLLPDNKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIARNGTCMTSEGRLVVKNAKFARDFGPLDPNCDCYTCKNYSRAYIRHLMKCDETFGIRLTSYHNLHFLLNLMEQVRQAIREDRLGDFREEFFEQYGFNKPNAKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: ATPI_SOLBU
Sequence: MNVLSCSINTLKGLYDISGVEVGQHFYWQIGGFQVHGQVLITSWVVIAILLGSATIAVRNPQTIPTGGQNFFEYVLEFIRDVSKTQIGEEYGPWVPFIGTMFLFIFVSNWSGALLPWKIIQLPHGELAAPTNDINTTVALALLTSVAYFYAGLTKKGLGYFGKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMLLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: HSCA_SHEPC
Sequence: MALLQIAEPGQSAAPHQHRLAVGIDLGTTNSLVAAVRSGETATLPDEDGQHSLPSIVRYTQDTVEVGALAALSSAQDPKNTIVSVKRFMGRSLTDIQTGEQSFPYEFAESENGLPLFVTPQGLVNPVQVSAEILRPLIARAEKTLGGELQGVVITVPAYFDDAQRQGTKDAAALLGVKVLRLLNEPTAAAIAYGLDSKQEGVIAIFDLGGGTFDISVLRLNRGVFEVLATGGDSALGGDDFDHLLQEHMQQVWLLGDIDVQLRRQLLIEARRVKEALTDANETEARIILADGSELKQVVTKRDFDSLISPLVKKTIASCRRTLRDAGVTAEEVLETVMVGGSTRVPLVREQVEAFFGKPPLTSIDPDRVVAIGAAIQADILVGNKPESDLLLLDVIPLSLGIETMGGLVEKVVSRNTTIPVARAQEFTTFKDGQTAMAFHVVQGERELVADCRSLARFTLKGIPPLAAGAAHIRVTFQVDADGLLSVTAMEKSTGVQSSIQVKPSFGLSDTEIATMLKDSMKYAKDDISRRMLAEQQVEAARVLESLHAALAKDGDLLNDDERGQIDATMANVAQLATGDDAEAIKQAIERLDEQTQDFAARRMDNSIRVAFKGQSIDNI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: HIS3_CITBB
Sequence: MIKIDFEKMGGLIPAVIQDNESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGEESGNTQDVVEVLTDCDADTVVIKVKQNGPAACHTGNRSCFYVRYENGAWVEHSNPLFDPNTVYKK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_CUPPJ
Sequence: MKRTYQPSVTRRKRTHGFRVRMKTRGGRAVINARRAKGRKRLAI
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: OPGG_ECO55
Sequence: MMKMRWLSAAVMLTLYTSSSWAFSIDDVAKQAQSLAGKGYEAPKSNLPSVFRDMKYADYQQIQFNHDKAYWNNLKTPFKLEFYHQGMYFDTPVKINEVTATAVKRIKYSPDYFTFGDVQHDKDTVKDLGFAGFKVLYPINSKDKNDEIVSMLGASYFRVIGAGQVYGLSARGLAIDTALPSGEEFPRFKEFWIERPKPTDKRLTIYALLDSPRATGAYKFVVMPGRDTVVDVQSKIYLRDKVGKLGVAPLTSMFLFGPNQPSPANNYRPELHDSNGLSIHAGNGEWIWRPLNNPKHLAVSSFSMENPQGFGLLQRGRDFSRFEDLDDRYDLRPSAWVTPKGEWGKGSVELVEIPTNDETNDNIVAYWTPDQLPEPGKEMNFKYTITFSRDEDKLHAPDNAWVQQTRRSTGDVKQSNLIRQPDGTIAFVVDFTGAEMKKLPEDTPVTAQTSIGDNGEIVESTVRYNPVTKGWRLVMRVKVKDAKKTTEMRAALVNADQTLSETWSYQLPANE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SCKH_MESMA
Sequence: MKIFFAVLVILVLFSMLIWTAYGTPYPVNCKTDRDCVMCGLGISCKNGYCQSCTR
What are the official names of this protein?
Neurotoxin X-29S.
What are the subcellular locations of this protein?
Secreted.
Protein: LEXA_PARPJ
Sequence: MTKLTARQQQVFDLIRRAIERTGFPPTRAEIAAELGFSSANSAEEHLRALARKGVIELAAGASRGIRLLAGPEDSPHQFTLPHASIMQLSLPLIGRVAAGSPILAQEHISQHYACDPALFSSKPDYLLKVRGLSMRDAGIFDGDLLAVQKRSEAKDGQIIIARLGDDVTVKRLKRRPNGLELIAENPDYENIFVETGSAEFALEGIAVGLIRPGEF
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: MURE_CALS4
Sequence: MRLVDLLKGVKHEIKGNPNVDISGVCYDSRKAKPKYLFIAIKGFKTDGLLYVEEAIKNGAVAVVTDRDISEYPGVTVVLVEDARAAMAKIASNFYNNPTSKLTLIGITGTNGKTSVTYMLKAILEQQNNKVGLVGTIQNMIGDRVIPTTHTTPESLDLQELFSLMVNEGVKYVVMEVSSHSLALHRVDSCDFDIAVFTNLSQDHLDFHESMEEYAKTKSKLFKMAKKASVINIDDKYSSMMIESSKGKVLTYGIKDFAYVMAKEIKNSLSGVKFKVQIQDKKEEISLKIPGLFSVYNALAAITVADFLGIPLRSVREALSHVTVKGRFEPVETGRDFYVFIDYAHTPDGIRNIMEALKEYEAGRKILVFGAGGDRDKSKRPLMGEVAGKYADFCILTSDNPRSENPKEIIAQIEEGIKKTNCPYVVIEDRREAIRYALSNAQKDDVIILAGKGHETYQIIGDKVIPFDEREIVKEILAESEK
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.