PharMolix/UniProtQA huggingface dataset:
Protein: PIGP_MOUSE
Sequence: MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVNKMFFLGAKELNT
What is the function of this protein?
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
What are the official names of this protein?
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5 homolog, Phosphatidylinositol-glycan biosynthesis class P protein, PIG-P.
What is the protein family that this protein belongs to?
Belongs to the PIGP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ARGDC_PYRIL
Sequence: MQTTTQVKTPIVGKHVYGELYGVDEALLRDEEKLRRIVIEAAHIAKMHLVEVNSWRFKGGDKEGVSVIALVLESHIAIHTWPVYNYATVDVYTCGEHSDPMAAFRYIVSQLAPKRFTVNYSDRSYK
What is the function of this protein?
Specifically catalyzes the decarboxylation of L-arginine to agmatine.  Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.
What are the official names of this protein?
Arginine decarboxylase proenzyme, ADC, ArgDC, Pyruvoyl-dependent arginine decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: IFNB_HUMAN
Sequence: MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN
What is the function of this protein?
Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:6157094, PubMed:6171735, PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041).  Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041).  Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity).  Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity).  Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity).  IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).
What are the official names of this protein?
Interferon beta, IFN-beta, Fibroblast interferon.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL18_BURM7
Sequence: MDKTQSRLRRARQTRIKIAELQVARLAVHRTNTHIYAQVFSPCGTKVLASASTLEAEVRAQLADKSGKGGNVAAATLIGKRIAEKAKAAGIESVAFDRSGFRYHGRVKALAEAAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RS15_LACPL
Sequence: MAISREKKTELINKYARHEGDTGSVEVQVAVLTEDINELNEHLRVHKKDFHSQRGLMKKIGHRRNLLAYLRKEDVNRYRDLIQSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SYFA_CHRSD
Sequence: MDHLPQLVAEARAAIESAEDVQSLDEVRVRYLGKKGEITALLKGLGKLPAEERPKAGEQINDAKQVLSDELEARKKHLQDAELNARLAQERIDVTLPGRGEPTGGLHPVTRTLERIESLFAHIGFDVAVGPELEDDYHNFEALNIPAHHPARGMADTFYFDASRLLRTHTSPVQVRTMKEQAPPIRIVCPGRVYRSDSDLTHTPMFHQVEGLLVDEDVSFADLKGTIEDFLKAFFERESLSVRFRPSYFPFTEPSAEVDIQCVMCGGDGCRVCSHSGWLEVMGCGMVHPEVFRHSGIDAERYTGFAFGMGAERLTMLRYGVNDLRLFFENDLRFLRQFG
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBB2_DOLAU
Sequence: SHQDCYEALHKCMASHSKPFSCSMKFHMCLQQQ
What is the function of this protein?
Has antibacterial activity against Gram-negative bacteria E. coli JM109 and DH5-alpha, H. influenza IID 983, and V. vulnificus RIMD 2219009.  Has antibacterial activity against Gram-positive bacteria S. aureus IID 1677, B. subtilis RIMD 0225014 and L. monocytogenes VIU206.  Possesses antifungal activity against S. cerevisiae A581A, S. pombe IFO 1628, C. albicans ATCC 36232 and TIMM-1623, and C. tropicalis TIMM-0313.
What are the official names of this protein?
Dolabellanin-B2.
What are the subcellular locations of this protein?
Secreted.
Protein: RS2_CHLT3
Sequence: MAQLKLEDLLKSGAHFGHLTRRWCPKMKPYIFMEKNGIHIIDLKKTVSLADDALNAVGAIASTGKEILFVGTKKQAKAIVAEQAERAGMPYVAERWLGGMLTNFSTIRQSIRRLNSIERMEIDGTFDMITKKERLMLMREKEKLVRVLGGISKMTRLPAAIFLIDVKKEHIAVREAYSLGIPIFAIVDTNCDPEFIDYVIPANDDAIRSIELITSSVADAIIDATAVQKDDEDAAATNLASEAQDEKSEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: TGT_KORVE
Sequence: MSMSFSFQVEATQGAARAGRMITPHGEVETPVFMPVGTVATVKGIPQDLLEELGVQILLNNTYHLYLRPGVEQIRKLGGTHKFMSWDRSILTDSGGFQVFSLSELRKVTEEGVSFRSHLDGSSHLFSPESAMASQIGIGADIIMAFDECTEYPAERTRTERSMELTLRWAERSKNAFEAHKHEVPWFAERGKKSQALFGIVQGGMFPNLRKESAERTVEIGFPGYALGGFSVGEPREKTAELVANTVPLLPENKPRYLMGVGYPEEIVQYARMGIDMMDCVLPTRAARHGLLFTSEGRLTIKNQRFASDEGPLDPNCSCKVCKRYSRAYLRHLYASNEVLAQVLNTTHNLSYYLDTMRRVRQAIILGENSVSLPVVRSPHLSAT
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: Y3932_BACCR
Sequence: MFGQRQSMIVYLHSLKHAKILRKYGNIHYISKRLKYAVVYCDMEQIEHMMHKLNKLPFVKKIEQSYRPYLKTEFENSRPDRAKEYDYS
What are the official names of this protein?
UPF0298 protein BC_3932.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXC4_HUMAN
Sequence: MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-C4, Homeobox protein CP19, Homeobox protein Hox-3E.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFP_EXIS2
Sequence: MVSVNDLKTGLTIKTSDGMIWQVLEFQHVKPGKGAAFVRTKMRNIRNGNIQEMTFRGGERVERAHIERNKMQYLYPMGETYVFMDTESYEQLELTTAQVEAALPFLLENMEVQIAIYNGEVLGIELPNTIVMTIVEAEPGVKGDTASNVKKNATVETGHIIHVPLFIEAGEKVTVDTRTGDFTGRYNG
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH3_AQUAE
Sequence: MPSLKISPSEAEKIQNYLVSSGFRKINAPYTLWALEGNGVKVYYYKTGSLLIQGKNSEKVLKEVLNLLEKKKLPGCDESGKGDIFGSLVLCCVCIPEENYLKVSSLNPRDTKRLSDKRVERLYLALKPLVKAYCYEIKPEEYNKLYRKFRNLNKMMTHFYKLLIERVKEECGVSEVVVDKYQPSNPFGEDVIFETEAERNLAVAVASIFARYKFLQSLKEVERELGIKIPKGTSKEVKELAKSLKNPERFIKLNFNV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIR1_VZVD
Sequence: MEFKRIFNTVHDIINRLCQHGYKEYIIPPESTTPVELMEYISTIVSKLKAVTRQDERVYRCCGELIHCRINLRSVSMETWLTSPILCLTPRVRQAIEGRRDEIRRAILEPFLKDQYPALATLGLQSALKYEDFYLTKLEEGKLESLCQFFLRLAATVTTEIVNLPKIATLIPGINDGYTWTDVCRVFFTALACQKIVPATPVMMFLGRETGATASCYLMDPESITVGRAVRAITGDVGTVLQSRGGVGISLQSLNLIPTENQTKGLLAVLKLLDCMVMAINSDCERPTGVCVYIEPWHVDLQTVLATRGMLVRDEIFRCDNIFCCLWTPDLFFERYLSYLKGASNVQWTLFDNRADILRTLHGEAFTSTYLRLEREGLGVSSVPIQDIAFTIIRSAAVTGSPFLMFKDACNRNYHMNTQGNAITGSNLCTEIVQKADAHQHGVCNLASINLTTCLSKGPVSFNLNDLQLTARTTVIFLNGVLAAGNFPCKKSCKGVKNNRSLGIGIQGLHTTCLRLGFDLTSQPARRLNVQIAELMLYETMKTSMEMCKIGGLAPFKGFTESKYAKGWLHQDGFSTISYLDLPWCTLRDDICAYGLYNSQFLALMPTVSSAQVTECSEGFSPIYNNMFSKVTTSGELLRPNLDLMDELRDMYSCEEKRLEVINILEKNQWSVIRSFGCLSNSHPLLKYKTAFEYEQEDLVDMCAERAPFIDQSQSMTLFIEERPDGTIPASKIMNLLIRAYKAGLKTGMYYCKIRKATNSGLFAGGELTCTSCAL
What is the function of this protein?
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis.  Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase large subunit, R1, Ribonucleotide reductase large subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: RS52_ARATH
Sequence: MATAADVDAEIQQALTNEVKLFNRWTYDDVTVTDISLVDYIGVQAAKHATFVPHTAGRYSVKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHAMEIIHLLSDLNPIQVIIDAIVNSGPREDATRIGSAGVVRRQAVDISPLRRVNQAIFLITTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDEIERVAKANR
What are the official names of this protein?
40S ribosomal protein S5-2, AtRPS5A, Protein ARABIDOPSIS MINUTE-LIKE 1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Y5516_ARATH
Sequence: MNSSHTAFVAASFFFLLLAATAVLVSADLASDEQALLNFAASVPHPPKLNWNKNLSLCSSWIGITCDESNPTSRVVAVRLPGVGLYGSIPPATLGKLDALKVLSLRSNSLFGTLPSDILSLPSLEYLYLQHNNFSGELTTNSLPSISKQLVVLDLSYNSLSGNIPSGLRNLSQITVLYLQNNSFDGPIDSLDLPSVKVVNLSYNNLSGPIPEHLKKSPEYSFIGNSLLCGPPLNACSGGAISPSSNLPRPLTENLHPVRRRQSKAYIIAIVVGCSVAVLFLGIVFLVCLVKKTKKEEGGGEGVRTQMGGVNSKKPQDFGSGVQDPEKNKLFFFERCNHNFDLEDLLKASAEVLGKGSFGTAYKAVLEDTTAVVVKRLREVVASKKEFEQQMEIVGKINQHSNFVPLLAYYYSKDEKLLVYKYMTKGSLFGIMHGNRGDRGVDWETRMKIATGTSKAISYLHSLKFVHGDIKSSNILLTEDLEPCLSDTSLVTLFNLPTHTPRTIGYNAPEVIETRRVSQRSDVYSFGVVILEMLTGKTPLTQPGLEDERVVIDLPRWVRSVVREEWTAEVFDVELLKFQNIEEEMVQMLQLALACVARNPESRPKMEEVARMIEDVRRLDQSQQLQQNRTSSEATSNVSE
What is the function of this protein?
Probable leucine-rich repeat receptor-like protein kinase.
What are the official names of this protein?
Probable leucine-rich repeat receptor-like protein kinase At5g05160.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GPPA_SHIFL
Sequence: MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENDLSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQENQWQSYVHWPLEVH
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: ZMIZ1_HUMAN
Sequence: MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQSDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPAQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQNIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPAPNPPRPLTSPNYPGQRMPSQPSSGQYPPPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTNSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQSGPPLHHSGAPPPPPSQPPRQPPQAAPSSHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN
What is the function of this protein?
Acts as transcriptional coactivator.  Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation.  The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984).  Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850).  Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC.  Involved in thymocyte and T cell development (By similarity).  Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (PubMed:30639322).
What are the official names of this protein?
Zinc finger MIZ domain-containing protein 1, PIAS-like protein Zimp10, Retinoic acid-induced protein 17.
Protein: PETG_GRATL
Sequence: MVEPLLSGIVLGLIPVTLFGLLVAAYLQYRRGNQFGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HIS6_SACD2
Sequence: MPLAKRIIPCLDVDKGRVVKGVQFVDIRDAGDPVEVAKKYNEQGADEITFLDITASVEGRETTVQTVEKIAAEVFIPLTVGGGIRTLEDIRTMLNAGADKVSINSAAVKDPEFVKAAAEGFGSQCIVVAIDAKKVSAEGEPPRWEIFTHGGRKPTGIDAIEWAIRMTDYGAGEILLTSMDKDGTKDGFDLAVTRAIADAVPVPVIASGGVGNLQHLVDGVIEGGADAVLAASIFHFGEYTVPQAKEYMQERGVEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_RUEST
Sequence: MSRRCELTGKGPMTGNNVSHANNKTKRRFLPNLNDVTLQSETLGRGVKLRISAAALRSVDHRGGLDAFLAKAKDEELSAAALKVKKEIAKAQAAEA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: SUH_PONAB
Sequence: MAWIKRKFGERPPPKRLTKEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPPNESNTNSEGSYTNASTNSTSVTSSTATVVS
What is the function of this protein?
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations.  Acts as a transcriptional repressor when it is not associated with Notch proteins.  When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes.  Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively.  Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.  Binds specifically to methylated DNA.  Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen).  Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).
What are the official names of this protein?
Recombining binding protein suppressor of hairless, J kappa-recombination signal-binding protein, RBP-J kappa.
What is the protein family that this protein belongs to?
Belongs to the Su(H) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA1, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
Protein: RS24_PYRHO
Sequence: MEIKITEVKENKLIGRKEIYFEIYHPGEPTPSRKDVKGKLVAMLDLNPETTVIQYIRSYFGSYKSKGYAKYYYDKERMLYIEPEYILIRDGIIEKKEGE
What are the official names of this protein?
30S ribosomal protein S24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: DEF83_ARATH
Sequence: MATNKFLSILLLSLMAFAAILLPMISGQIITCLPGECTNPSECNAACKSNGYKGGACVSMSIGSTTGACCCKPNFKSQDSFKSNDIIINNN
What are the official names of this protein?
Putative defensin-like protein 83, Putative low-molecular-weight cysteine-rich protein 46, Protein LCR46.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENO_PROM2
Sequence: MKETIDFLIDTIEARQVLDSRGNPTVEAEVFLECGASGIAIVPSGASTGAHEAHELRDGGSKYMGKGVLSAVNKIHETISPALCGLSALDQTAVDKLMTEIDGTLNKSNLGANSILAVSLATARASANALDIPLYRYLGDPLSNLLPVPLMNVINGGAHAPNSLDFQEFMLVPHGVNNFSESLRMGTEIFHSLKSLLDQKGLSTAVGDEGGFAPNLSSSEEAGDLLLEAIQKAGFKPGEQVSLALDAASTEFYNDGIYKYEGKSLNSSEMISYLSRLVSNYPIVSIEDGLAEDDWEGWSELNKELGDKVQLVGDDLFVTNTERLRKGIMEKSANSILIKVNQIGTLTETLEAIELAKMSGFTSVISHRSGETEDTTIADLSVATRSGQIKTGSLSRSERIAKYNRLLKIEEELGNQARFAGALGLGPKNI
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL9_PSEAB
Sequence: MEVILLEKVANLGNLGDKVNIKGGYARNFLLPQGKATVATAENVAAFEARRAELEKAAAEKKAAAEARAAQLSELVVTLGAHAGDEGKLFGSIGTRDIAEAVSAAGYPLEKAEVRLPNGALRNTGEFDVAVHLHTDVETTLKLIIVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: Y898_MYCBO
Sequence: MRIGVGVCTTPDARQAAVEAAGQARDELAGEAPSLAVLLGSRAHTDRAADVLSAVLQMIDPPALVGCIAQAIVAGRHEIEDEPAVVVWLASGLAAETFQLDFVRTGSGALITGYRFDRTARDLHLLLPDPYTFPSNLLIEHPNTDLPGTAVVGGVVSGGRRRGDTRLFRDHDVLTSGVVGVRLPGMRGVPVVSQGCRPIGYPYIVTGADGILITELGGRPPLQRLREIVEGLSPDERALVSHGLQIGIVVDEHLAAPGQGDFVIRGLLGADPSTGSIEIDEVVQVGATMQFQVRDAAGADKDLRLTVERAAARLPGRAAGALLFTCNGRGRRMFGVADHDASTIEELLGGIPLAGFFAAGEIGPIAGRNALHGFTASMALFVDDME
What are the official names of this protein?
Uncharacterized protein Mb0898c.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv0628c.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLMI_YERPY
Sequence: MTVRLILAKGREKSLLRRHPWIFSGAVQRLEGDALSGETIDILDSQGKWLARAAYSPESQILARVWTFQQDEVIDCAFFIRRLQQAQNWRDWLAQRDGLNGYRLIAGESDGLPGITIDRFQNFLVLQLLSAGAEYQRETLVSALQHCYPECSIYDRSDVSVRKKEGLPLTQGLICGEMPPALLPISENGMQLFVDIQQGHKTGFYLDQRDSRLAARNYANGRRVLNCFSYTGAFAVAALMGNCQQVISVDTSQSVLDIAKQNIELNQLDLSKTEFVRDDVFQLLRSYRAQGEKFDLIIMDPPKFVENKSQLASACRGYKDINMLAIQLLRPGGILLSFSCSGLMPVDLFQKILADAALDAGHDIQFIEQFRQAADHPVIAAYPEGLYLKGFACRVM
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.