PharMolix/UniProtQA huggingface dataset:
Protein: ATPL_HELP2
Sequence: MKFLALFFLALAGVAFAHDGGMGGMDMIKSYSILGAMIGLGIAAFGGAIGMGNAAAATITGTARNPGVGGKLLTTMFVAMAMIEAQVIYTLVFAIIAIYSNPFLS
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRPE_BORPA
Sequence: MTAPQEPVDSTPESGENAATPGLEDDLSAELAALRAELEAAQATVKAQQEQVLRAAAEAENVRRRAQEDVAKARKFGIESFAESLVPVKDSLEAALAQPDQAAQAWREGVEVTLKQLTAAFERNLLKEIAPAQGDKFDPHLHQAISSVPADQPANTVLQLLQKGYVIADRTLRPALVVVSAGQG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_SHEFN
Sequence: MTDKYAVFGNPIAQSKSPFIHTEFAKQTQQDLSYEAILAPVDQFDSSLVAFFADGGKGANVTAPFKEQAFSMCDELSEMAKLAGSVNTLFNLPYGKIGGDNTDGVGLVNDLEMLFGSLKGKRVLLVGAGGAARGCILPILQHNVAQLIICNRTHEKAEQLQTLFNEYGNFFAKPIEELISPFDLVINSTSAGLSGQLIALPSVIVDETTDCYDMTYSQQTTVFNQWAQAQNARKTADGLGMLVGQAAKSFSLWRGITPDTGSVMRKLRESLAQEAID
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: TATD_ESCF3
Sequence: MFDIGVNLTSSQFAKDRDDIVTRAFAAGVNGLLITGTNLRESQQAQKLARHYPHCWSTAGVHPHDSSQWQAATEEAIIELAAQPEVVAIGECGLDFNRNFSTPEEQERAFVAQLRIAAELNMPVFMHCRDAHERFITLLEPWLEKLPGAVLHCFTGTREEMQACVARGIYIGITGWVCDERRGLELRELLPLIPAEKLLIETDAPYLLPRDLTPKPTSRRNEPAYLPHILQRIAQWRGEDAACLAATTDTNVKTLFGISF
What is the function of this protein?
3'-5' exonuclease that prefers single-stranded DNA and RNA.  May play a role in the H(2)O(2)-induced DNA damage repair.
What are the official names of this protein?
3'-5' ssDNA/RNA exonuclease TatD, DNase TatD.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METXA_CORU7
Sequence: MRSDLLPASGTYADIPIGEVLTEAGASIPETSLRLYAFYDAAEQAAVPTPPEERPIVLIEHALTGDGNAADWWADMVGVGKPIDTAKYLVLCANALGGCAGSTGPSSLHPEGGFWGSRFPGLSIRDLVQAEKQLLDVLEIPRVHVIIGASMGGARTLEWSLLYPEMMDAILPIAVSARASAWQIGIQSAQIRVIEADPLWHGGDYYEAGMGPVWGLGEARRIAHLTYRGELEVDERFGAEPQQGENPLGKFRSPDQRFSVEGYLDRQAMKLRNRFDAGSYVTLTDALNRHDLGRDRGGMNAALGNSTVPTMVCGIDTDILYPYHQQEHLSRNLGTFLGLSQITSPTGHDGFLIEARQMGNVLEKFLVTAEKLAKDPEQRANILQQHHH
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNY_AYWBP
Sequence: MKDASWRDHCTMGCSLFFLALICGSIIGYFLYSFFNQKKLEEKKQAFDNKLKEKEKDLQKREQEMMRNAKIEIASLRQKLELDLEQRTNTIVDLESKNNRREELLNNRTESLNKREEHLDSEKQIISHTKKNLEQQIKEQETILNTQKQQLEKIASLTQDQARQIIMKETRDQTTYEMMSYIKQEEEKAKSEASKKAKTLLVLAMQKYSGDITGEKNISVVNIPNEDMKGRIIGRQGRNIKSLEVLTGVDLIIDESPCTVILSSFDPIRREIAKKTLEFLVSDGRIHPSRIEKALETSTIEVDNFIKEMGEEATFITKIGEVHPDLIKILGKLHFRISYSQNVLKHSLEVAFLAGKLASEIGENEILARRAGLFHDIGKALDHEMEGSHVEIGVSIASKYKEKKEVIDAIASHHEDQEPQSIIAALVAIADTLSSARPGARKESVENYIQRLTKLETIANSTKGVAKSYAIQAGREIRVIVEPDKIADNFIFQTARTIKEQIEKEIIYNGVIKVTVLRETRAVEMAKL
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: AAEB_ECOSM
Sequence: MGIFSIANQHIRFAVKLATAIVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGFLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRIENSYAWGLAGYTALIIVITIQPEPLLTPQFAVERCSEIVIGIVCAIMADLLFSPRSIKQEVDRELESLLVAQYQLMQLCIKHGDGEVVDKAWGDLVRRTTALQGMRSNLNMESSRWARANRRLKAINTLSLTLITQSCETYLIQNTRPELITDTFREFFDTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWVAAATRYQLLKRGVISNTKINATEEEILQGEPEVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCISLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAVSAMTTNVARRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSAFHRQMRRTADHVISARSDDKRRRYFGQLLEELEIYQEKLRIWQAPPQVTEPVHRLTGMLHKYQHALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HBA1_SCHPO
Sequence: MTSKMENNKDESISTKNALEEKSNETKDETSKRKHDPAEEESAVSTKVSKSEPLEDKGNAEVKEFKETTKSNGVKPEVEITESTKIQKESNTEPCISTGGKVEEKELKVNKDVDENEGHVAVETGKKESAAKPAASVSPFSQFASFSNASSPFSNVSTASSEPKEEKSAFGAFASSKSAFTMKSVKDSPFKKFAAGTAVETESGSGKEKENDKKSSENFDELLANTSAKAFENQKGSAGETKSEPKEADKGSGDSTKSTMHQLSDSEIITGEEEEESIFSVRARLYVVADEKKTWKERGQGILKVNVPKQRGSGSGRLLMRNDAVHRVIMNVPLFQGMSKKSLQIASASSGGSANYLKIFVIENGKSVLYAVRVKDNSLAEQLRNHVLEAIPKGGREDA
What are the official names of this protein?
Brefeldin A resistance protein, Caffeine resistance protein 1.
Protein: MSBA_BURL3
Sequence: METQNTLRKPMDGTGTSPVTVLKRLWPYIRPLIGIVVLAVMTMGVVAATEAGIPALLKPLLDHGFGSHGSDSAKWYVPMAVIGLALVRGVSQYASNYLLNYVSNRILLQLRLEMFQRMLHTGASFFQRETASTVINAIVFEVNQILSVLTGVMVTLVRDSLTVIFLLGYLFYLNWRLTLIVAVILPGIGWLVSKINRRLRRLNREHQTLTNELSYIVEETVGGYKVVKVHNGEAYEMDRFTQMSKRLRGYAMRMTISGGLAQPLTQFLASIALAVVITIAVVQSSNDQTTVGGFVAFVTSMLLVISPLKHLIDVNQPLQRGMTAAELIFGLIDEPAEPQGGGRPLAQSRGDIEFRNVTFDYGAAERPTLDRISFKVAPGEMIALAGPSGSGKTTLVNLLPRFFDPTDGAILVDGVPVADYDLHALRSQMAMVSQDVVLFNDTIAANVAYGQTPDRARVQAALEAANLADAVAAMPDGLDTLVGGNGMRLSGGQRQRLAIARAIYKDAPILILDEATSALDSESERHVQAALERLMEGRTTLVIAHRLSTIERADRILVLEAGKIVEEGSHDELLRHGGLYAHLHRIQYQQQAA
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YMO7_YEAST
Sequence: MRKKCPQGKKLLKKATRPFVGAFRRRIRAKKNLISQFGQTGCIGCDGKFSIGITIEKYVLNLVVRIIIVFALCRITELSVFDSSLRCKSRKTRLSKAARKKETDHFHEQCRYVEVKFGLQMAYLQS
What are the official names of this protein?
Uncharacterized protein YMR007W.
Protein: RL23_PARMW
Sequence: MTERFQGRLADVIRRPLITEKATRALEFNQYTFEVDHRAAKPDIKAAIEQLFDVKVTGISTMNPPRRTRRMGRFAGKRAQVKKAVVRLAEGNSIQLFPES
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RNH3_STRGC
Sequence: MGQFTLTPSEQEIQAFLKQYKKYLSSSKNPYIRYFFRLEQATASVYTSGKLLLQGEEADKYALFFKETADLTRPPQKITYQAMIGTDEVGNGSYFGGLAVVASFVTKEQEDFLRKLGVGDSKTLTDQKIRQLAPILKEKITHQALLLSPKKYNQVIASGYNAVSVKVALHNQAIYLLLEKGIKPDQIVIDAFTSSTNYQRYVKQERNQVSQAIHLEEKAEGKYLAVAVSSIIARDLFLENLEILSQELGYQLPSGAGAKSDQVASQILKAYGMAGLETSAKLHFKNTQKAKQLLER
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCDC_ACIFV
Sequence: MRKFNVNVNGTVYTVEVEEVGGAVTAAPAAPAAPAAAPAAAPVAAAPAAAPAPAPAAAPAAAPAPAAKPAAAAPAGSVTVSAPMPGKILSVNVKPGDKVEAGDVLLILEAMKMQNEIMAPEDGTVSEVRVNAGDTVATGDVMVIL
What is the function of this protein?
Biotin carrier subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).
What are the official names of this protein?
Glutaconyl-CoA decarboxylase subunit gamma, Biotin carrier.
Protein: NGFV1_NOTSC
Sequence: MSMLCYTLIIAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELGSVANIIVDPKLFQKRRFQSPRVLFSTQPPPLSRDEQSVEFLDNEDTLNRNIRAKRENHPVHNQGEHSVCDSVSDWVIKTTATDIRGNMVTVMVDINRNNEVYKQYFFETKCRNPNPNPVQSECRGIDSRLWNSYCTTTQTFVRALTMEGNQASWRFIRIDTACVCVIIRKTDNF
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor 1, v-NGF-1, vNGF-1.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: EX7S_RUTMC
Sequence: MAKKFDFNQGLIDLEKIVKTMESGDLSLENSLDYFSKGVALTKLCQSALNEAEQKIFMLTEQDNYTNENPLKDL
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGT5_YEAST
Sequence: MCDSPATTGKPTILFIADPCETSATLNSKAFKEKFRILRYQLDTKEAFLNFLERHEQDKICAIYAGFPAFKKIGGMTRSIIEHKSFPRKNLKCIVLCSRGYDGWDLDTLRKHEIRLYNYQDDENEKLIDDLKLHQVGNDVADCALWHILEGFRKFSYYQKLSRETGNTLTARAKAAEKSGFAFGHELGNMFAESPRGKKCLILGLGSIGKQVAYKLQYGLGMEIHYCKRSEDCTMSQNESWKFHLLDETIYAKLYQFHAIVVTLPGTPQTEHLINRKFLEHCNPGLILVNLGRGKILDLRAVSDALVTGRINHLGLDVFNKEPEIDEKIRSSDRLTSITPHLGSATKDVFEQSCELALTRILRVVSGEAASDEHFSRVV
What are the official names of this protein?
Putative 2-hydroxyacid dehydrogenase YGL185C.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: EIF3L_ASPCL
Sequence: MSYEERVNAHPNLGDESDVEEEALVNDYREQVNFDDGMSELERTTSLGAASQTQDLQAQLAAAATPLEYQATLETKFASYDNYCSLFHYILNSEGPVELEVPSYYWAWDVIDEFIYQFESFCRYRNRVARSGSNEEEAQLLRENPNTWGCYSVLNVLYSLIQRSQINEQLAAIKRGEDPLTVAGEYGSRPLYKMLGYFSIIGLLRVHCLLGDFSLALKTLDDIEMNKKAMFARVMAAHFTTYYYVGFSYMMMRRYGDAIRMFSHILVYVSRTKNFQKGGNSYDAIAKKNDQMYALIAICVALHPTRLDDTIHSALREKYGEQLIRLQHGGPEALPLFEELFRSACPKFISPTPPDFDNPAVNVDPVDHHTAIFMDEVKNTLYNPTIRSYLKLYTTMDLKKLAGFLEVEPEKLRSWLLVNKQRSRQVRWVEGGLLEGEPVNANDLDYALENDLIHVSETKAGRRLVDWYLRNLARVY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_MAGMM
Sequence: MIEELHQEVSDRGFLLTSADKLVNWGRSMSMWPMTFGLACCAVEMMNAGASRYDLDRFGVVFRGSPRQSDVIIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRILPVDVYIPGCPPTAEAVMYGIMQLQKKINREGQVYSGWRKRV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CDSA_RICBR
Sequence: MIIQKGKEHLAKDKQKSNLYLRILSGIVLVPSFVVAILWLKPLFYVLMILVAIGMLSEWYDMTHSSIMYLLIGLIIIPIPISLLIFLSSNPINNWLIMLYFCIVWSVDIFAMIGGKTLGGAKLAPKISPKKTWSGLITGILSAGLVATLISFIPSFYIENYYFSNRIYLFIISCTLALTAQLSDLFISYFKRKFNIKDSGNIIPGHGGVLDRFDSIILTAPILFFINGLYL
What are the official names of this protein?
Phosphatidate cytidylyltransferase, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MOAC_SHIF8
Sequence: MSQLTHINAAGEAHMVDVSAKAETVREARAEAFVTMRSETLAMIIDGRHHKGDVFATARIAGIQAAKRTWDLIPLCHPLMLSKVEVNLQAEPEHNRVRIETLCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDMVIGPVRLLAKSGGKSGDFKVEADD
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: ARGJ_CITLA
Sequence: MYLSVPHYPSLKFTAFQSHKRNFRVFAVATNEAANYLPEAPILIPDGPWKQIDGGVTAAKGFKAAGLYGGLRAKGEKPDLALVTCDVDAISAGAFTKNVVAAAPVLYCKKALDISETARAVLINAGQANAATGDAGYQDVIECVNNLSKILQIRPEEILVESTGVIGHRIKKDALLNSLPQLVRSLSSSVGGAASAAVAITTTDLVSKSVAIESQVGGSTIRIGGMAKGSGMIHPNMATMLGVVTTDAVVACDVWRKMVQISVDRSFNQITVDGDTSTNDTVIALSSGLSGFNSNIISSLKSREAGQLQECLDVVMQGLAKSIAWDGEGATCLIEITVSGASTEAEAAKVARSVAGSSLVKSAIYGRDPNWGRIAAAAGYAGVPFDQMKLKVSLGNILLMDGGEPQSFDRAAASNYLRRAGETHDTVRIFISIGDGQGEGRAWGCDLSYDYVKINAEYTT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RSMG_STAHJ
Sequence: MNGIEWLAKELSEHGIELSDKQKEQFQTYYRLLVEWNEKMNLTSITDEHEVYLKHFYDSITPSFYYDFNQPLTICDVGAGAGFPSIPLKVVYPELKVTIVDSLNKRIQFLNHLAAELGLTQVSFVHDRAETFGKGVNRETYDVVTARAVARLTVLSELCLPLVKKGGQFIALKSSKGEEELEEAQFGISILGGVFSDSYTFDLPEDAGERQMIIIDKRRQTSKKYPRKPGTPNKSPLLEN
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 535 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CXCR4_CERAT
Sequence: MEGISIYTSDNYTEEMGSGDYDSIKEPCFREKNAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQKPRKLLAEKVVYVGVWIPALLLTIPGFIFASVSEADDRFICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
What is the function of this protein?
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation.  Involved in the AKT signaling cascade (By similarity).  Plays a role in regulation of cell migration, e. g.  during wound healing.  Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels.  Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).  Involved in hematopoiesis and in cardiac ventricular septum formation.  Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells.  Involved in cerebellar development.  In the CNS, could mediate hippocampal-neuron survival (By similarity).
What are the official names of this protein?
C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, Fusin, Leukocyte-derived seven transmembrane domain receptor, LESTR, Stromal cell-derived factor 1 receptor, SDF-1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).
Protein: SYVM_RAT
Sequence: MPHLPLASFRPPLWGLRPSWGLARPRALCTQPEPHGSPVSRRNREAKQKRLREKQAALEAGLAEKSKTPAVPTKAWSHKEVVLYEIPTRPGEKKDVSGPLPPAYSPQYVEAAWYQWWVREGFFKPEYQARLPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDAFVRWHRMRGDRVLWIPGSDHAGIATQAVVEKQLWRERRVRRHELSREDFLRAVWQWKQEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYDLGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRTVLRLPGCPIPVSFGLLVSIAFPVDGDPGTEIVVGTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQHLPLITDTTVQPHVGTGAVKVTPAHSPADAEMGTRHGLTPLSVIAEDGTMTSLCGDWLQGLHRFVAREKIMCTLRERGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDRAAKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVGGEKAEDDREECWVVGRSEAEARAAAAKQTGRPEAELTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLTLLETGSDLLTFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISGQELQVLQAKLRDGNLDQGELAVAAAAQKKDFPYGIPECGTDALRFALCSHGILGGDLHLSVSEVLNYRHFCNKLWNALRFILRALGDDFVPQPAEKVTPSSPMDAWILSRLAFAANECERGFLSRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSSAPCPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRQGGSMAPSICVAPYPSGHSLVSRGQESWRQPELEHCFSRVQEIVQALRALRATYQLTRARPHVLLQSSDPGEQGLVQPFLEPLGVLSHCGAVGFLPPGAAAPSGWALAPLGDTIKIYMELQGLVDPQSQLPRLAARRQKLQKQLDDLLNRTVSDGPAERQQRISSLQLELSKLDQAASHLQQLMEEAPDAREL
What are the official names of this protein?
Valine--tRNA ligase, mitochondrial, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HEM1_PROM2
Sequence: MHIVVVGVSHRTAPVEVREKLSIPDHSITESLKALKAFSEVLEVSILSTCNRLEIYALAKDKNTGISSIKEFLSEYSGIIFEDLDPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQVKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGTGAVSISSAAVELAQLKIGQEKGFDTLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILVNRNIDRALNLAQDFPDLKIVCRGLNELDENISISSLVFTSTASEVPIIDLAKIEKLNLNNKLKFIDIGVPRNISNDVKQHEFVKSFDVDDLQEVVSRNQEFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSDLELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKILHTPVTKLRSPQSREERQVSLKIVEKLFSLAEEDKNN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.