PharMolix/UniProtQA huggingface dataset:
Protein: LEXA_BARQU
Sequence: MLTCKQYELLLFIHNHMKEIGVPPSFDEMKIALELTSKSGIHRLITALEERGFIRRLPNRARAVEVVRLPEKITFNLSSARKISPNVIENNRRKISKNSKNLNNFDIEDKKNVTVPIMGRIAAGVPVSAIQQQTNTLCLPADMISLGEHYALEVKDDSMIEAGILDKDTIIVRRQNTATPGEIIIALIDKEEATLKRYRRNGASIALEAANPHYETRIYRPERIEIQGKLIGLIRKY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: CFD1_DEBHA
Sequence: MDTSEPQESPKSLSNVKHIILILSGKGGVGKSSVTTQTALTLVNKGFNTGVLDIDLTGPSLPRMFGVETKQVHQSSAGWVPVSVYNNGQEKNEENKRGNLSLMSLGFLIGNRNSSVVWRGPKKTAMIRQFLKDVVWSGGENNVPLDYLLIDTPPGTSDEHIAIAEELRWANPDGAIIVTTPQQVATADVRKEINFCKKVNFDVLGVVENMSGFICPHCSECTNIFSSGGGKELSEKLDLQFLGNIPIDPSFVEMVEMQDNDQNDGKKKLVDLYDDCELKGIMEGIVDKVLEQQHPARF
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.  Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor CFD1, Cytosolic Fe-S cluster-deficient protein 1.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTH_ECOL5
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRRKLKRVLWIPVEGERSIPLAKRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQIERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXB_ECO27
Sequence: MKILVDENMPYARDLFSRLGEVTAVPGRPIPVAQLADADALMVRSVTKVNESLLAGKPIKFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSSLLMLAERDGFSLHDRTVGIVGVGNVGRRLQARLEALGIKTLLCDPPRADRGDEGDFRSLDELVQHADILTFHTPLFKDGPYKTLHLADEKLIRSLKPGAILINACRGAVVDNTALLTCLNEGQKLSVVLDVWEGEPELNVELLKKVDIGTPHIAGYTLEGKARGTTQVFEAYSKFIGHEQHVALDTLLPATEFGRITLHGPLDQPTLKRLVHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVICDDASAASLLCKLGFNAVHHPAR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 6PGL_ECO57
Sequence: MKQTVYIASPESQQIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAYRIAPDDGALTFAAESALPGSPTHISTDHQGQFVFVGSYNAGNVSVTRLEDGLPVGVVDVVEGLDGCHSANISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTVEGAGPRHMVFHPNEQYAYCVNELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTRWAADIHITPDGRHLYACDRTASLITVFSVSEDGSVLSKEGFQPTETQPRGFNIDHRGKYLIAAGQKSHHISVYEIVGEQGLLHEKGRYAVGQGPMWVVVNAH
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: RL20_BORGP
Sequence: MARAKNGTVHVARRKRILKKTKGFWGTKKSNYKKAKDTLRKGMMYATRDRKARKRDFRRLWISRISAALSDTGISYSRFIEGLLKSNIKINRKILSNLAIEDAEAFKKIVLEIRR
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: Y114_MYCPN
Sequence: MDTKLTPPWLRQENNLLNPEVTQRLFINQDNIPNLPTEAPQVYLARFLEWVEPLVSKVKFVKAQAAVQDYLNSKACAQIETIIAERAQNTHSSWLANWWVQYAYLTSTGPVSPEVNAPYYLELPTVGWSQAELAAALSAQLWHIYQQVQKRQLTSFSVKDKLFSLDTLQSIFASCQIHRADGDVYFVNDQPANFIVVIKNNVFYKLVIDNSGSLEQLQAQLQLSFVQILDNELSHPPHWNLLTATTTKAESQSLLDQLWAQNPEMLLDIYNSAFIVNLDNVELTTPLQLLRNSTWTPNFNRWHAKGIQLVITKNAQLVILADHTSFDGSSVATLANIFVSKLQKVNTEGASALTPTMLSFPTVDQDKQKYFKQLSKNFKDYVYNAVMFELKWDWFTKPLIKAKGIKNSEAFIHLCYQIAQYQTNKKLQNTYVAVDMRQYFRGRTECLRPLSKQSVAFVKRYCKDPKGTLKQFRKYYPAIESLHFEKTRLAQKGSGVNRHLLGAYLAWNEHQDTIAKPALFETKAWKTIAANPLSTSSIVDKYLRNFSFDPVEPNGIGIAYAIDDTNFRAILSVYQHNLQYLKDWMKHFEQTVKTILKTLK
What are the official names of this protein?
Putative acetyltransferase MPN_114.
What is the protein family that this protein belongs to?
Belongs to the carnitine/choline acetyltransferase family.
Protein: HSH2D_MOUSE
Sequence: MAEARRLPPPLPPRLDWFVHTQADLLAQSGIPEWFHGTISREAAENMLESQPLGTFLIRVSHSHVGYTLSYKAQTCCRHFMVKLSEDGTCAFAGDHMTHASLHALVTFHQQKPIRPFGELLTQACGQEDPANVDYEDLFLYSNALVQDAESQILRTEVQRSSCPPEEASERKPSTTTKGEFASASCSPKALFEDSGQKLWKNLRSLPQTSQRVKQRLTSHLLAMNLLGDARQVAQQHHSPVTRAFSWDSTSHSEDSCAATTSLQNPAEPQALRGREATFRDSRPASWRKAFSGVKAWRGKVVRALSAQEPVDFPEAQGWLPEEYLPPPPFAPGY
What is the function of this protein?
Adapter protein involved in tyrosine kinase and CD28 signaling (By similarity).  May be a modulator of the apoptotic response through its ability to affect mitochondrial stability.
What are the official names of this protein?
Hematopoietic SH2 domain-containing protein, Hematopoietic SH2 protein, Adaptor in lymphocytes of unknown function X.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: GUAA_SHIDS
Sequence: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFITVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRVDAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RHOD_HUMAN
Sequence: MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLRKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSRGRNFWRRITQGFCVVT
What is the function of this protein?
Involved in endosome dynamics.  May coordinate membrane transport with the function of the cytoskeleton.  Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB.  Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling.  Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
What are the official names of this protein?
Rho-related GTP-binding protein RhoD, Rho-related protein HP1, RhoHP1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome. Note=Colocalizes with RAB5 to early endosomes (By similarity).
Protein: VE1_HPV51
Sequence: MDCEGTEDEGAGCNGWFFVEAIVEKKTGDNVSDDEDENADDTGSDLINFIDSETSICSQAEQETARALFQAQELQANKEAVHQLKRKFLVSPRSSPLGDITNQNNTHSHSQANESQVKRRLLDSYPDSGYGNTQVETVEATLQVDGQHGGSQNSVCSSGGGSVMDVETTESCANVELNSICEVLKSSNAKATLMAKFKELYGISYNELVRVFKSDKTCCIDWVCALFGVSPMVAENLKTLIKPFCMYYHIQCLSCDWGTIVLMLIRFSCAKNRTTIAKCLSTLVNIPQSQMFIEPPKLRSTPVALYFYRTGISNISNTYGETPEWITRQTQLQHSFEDSTFELSQMVQWAFDHEVLDDSEIAFHYAQLADIDSNAAAFLKSNCQAKYVKDCGTMARHYKRAQRKSLSMSAWIRYRCDRAKDGGNWREIAKFLRYQGVNFMSFIQMFKQFLKGTPKHNCIVIYGPPNTGKSLFAMSLMKFMQGSIISYVNSGSHFWLQPLEDAKIALLDDATYGCWTYIDQYLRNFLDGNPCSIDRKHRSLIQLVCPPLLITSNINPQEDANLMYLHTRVTVLKFLNTFPFDNNGNAVYTLNDENWKNFFSTTWSRLDLEEEEDKENGDPMPPFKCVPGENTRLL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ACSA_XYLFT
Sequence: MSDLYTIDPMLAKDAHIDRAHYKTLYHESIEQPEAFWNKVSQRLEWFKAPTKIKNVSYQLEDVHIRWFEDGELNASVNCLDRHLTLRGDKTALLFEPDAPDAPSSRITYRELYERVCQLGNALRHLGIEKGDRVTIYLPMIPDAVVAILACARIGAIHSVVFGGFAANSIADRVNDCGSKLIITADEGLRGGRKIPLKANVDAALKIHGTQSVETVLVVRHTGSTINMHTPRDRWFHDLVDIQATECAPERMNAEDSLFILYTSGSTGKPKGVLHTTGGYLVYTSYTHETVFDLRENDIYWCTADIGWITGHSYIVYGPLANGTTVLLFEGTPHYPTVSRFWEVIDKHHVTLFYTAPTAIRALMREGDTPVKKTSRKSLRLLGSVGEPINPEAWHWYYTIVGNGRCPIVDTWWQTETGGILITPLIGATDLKPGSVTLPFFGIRPALVDTNGQTLDGPAAGNLVLLDSWPGQMRTLYGDHQRFIDTYFRTYPNTYFTGDGCRRDADGYYWITGRVDDVINISGHRIGTAEIESTLVAHPKVAEAAVVGFPHPIKGQGIYAYVTLITGETPSEALHQELLTWVRKEIGAIAIPDHVQWASNLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSIVDLLLNERLKH
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: CMKMT_XENLA
Sequence: MESSVPLGNSVRTGAACGRIMAVPSKAAQGDARARWKLLGQALRKERLDDSLQKVSVRRFNSFRLFSVVEMKEIKREADCQTWFQYTCVFCPQYSLCLRHNSGISNVADILTSFDNTGNVCVWPSEEVMAYYCLKHKDIFRGLAVCELGGGMTCLAGLMVAISADVKEVLLTDGNEKAIKNVSDIIRRPQNEEMFKDRLVSSRVLRWDNETDVSQLEGHFDIVICADCLFLDQYRACLVDAIKRLLKPSGKAMVFAPPRGNTLSQFCNLAEAAGFSIQRHENYDEHISNFHSKLKEKEAAVYDENLHYPFLLVLCKTR
What is the function of this protein?
Catalyzes the trimethylation of 'Lys-116' in calmodulin.
What are the official names of this protein?
Calmodulin-lysine N-methyltransferase, CLNMT, CaM KMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y3483_SHESW
Sequence: MARPKKCRQLSSCVPCSLFKPNGIPSVELTHIQLEADEFEALELGDVQRLSQLDAAALMGISRQTFGYLLASARKKVATAITQGEVLRLPSKTDKDLS
What are the official names of this protein?
UPF0251 protein Sputw3181_3483.
What is the protein family that this protein belongs to?
Belongs to the UPF0251 family.
Protein: RNY_LACLM
Sequence: MDIISIVLLVLLVVLVVAFIFYAQNIKKNKQDAESLFNEAENKANEVMASAKREAESLKREAEAFKKEARYTLREEEQKQRREIEDEFKQERQELKETEKRLKQREEILDRKDDTLTKKEENLDSKEENLVRKTDTLSKREEQLAHIEEKKRLELERISNLSMDDAREIILSETRDGLTKEMAQTIRQSEEKAQAEADKRAKNIISLAIQRVSSDSVAEQTVSVVNLPDDGMKGRIIGREGRNIRTFEALTGIDVIIDDTPEAVVLSGFDPIRREIARMTLEQLVQDGRIHPARIEELVEKNRKALDHKMREYGEQAAFEVGAHNLHPDLMKIMGRLHFRTSYGQNVLDHSVEVAHIAGNLAGEMGENEALAKRSGFLHDIGKALDHEVEGSHVEIGTELARKYKENPIVINTIASHHGDTEPLSNIAVLVAAADALSAARPGARRESIENYIKRLKDLEAISTSFDGVETAFALQAGREIRVMVKPDKLTDDQIVILARDVKNRIEDEMDYPGNIKVTVIRETRAIDYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MUC24_RAT
Sequence: MSGASRGLFWAATCLAALCLSAAQSNSSASPNVTDPPTTTSKVVPTTLTTTKPPETCESFNSCVSCVNATLTNNITCVWLDCHEANKTYCSSELVSNCTQKTSTDSCSVIPTTPVPTNSTAKPTTRPSSPTPTPSVVTSAGATNTTVTPTSQPERKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL
What is the function of this protein?
Sialomucin that may play a key role in hematopoiesis.  May be involved in cell adhesion.  Promotes myogenesis by enhancing CXCR4-dependent cell motility.  Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).
What are the official names of this protein?
Sialomucin core protein 24, MUC-24, Endolyn, Multi-glycosylated core protein 24, MGC-24, MGC-24v.
What is the protein family that this protein belongs to?
Belongs to the CD164 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.
Protein: ILVD_CAMFF
Sequence: MRSDIIKDGYTRTPHRSLLRATGLKDDDFKKPFIGVANSFIEIIPGHFFLNKYSEILKDEIRKNGCVPFEFNTIGVDDGIAMGHEGMLYSLPSREIIANSVETVMNAHALDALVCIPNCDKIVPGMLMGALRVNVPTIFVSGGPMAAGVGAKGEALDLNSAFEAVGAYETKQIDEKELKFIECNACPSGGSCSGMFTANSMNTLCEAMGVALEGNGTVLALTSEREELIRKAARRICEIALDERYQIRNIINEKTIKNAMVVDMAMGGSSNTILHMLAISREAGYPLDIASLNDISRSVPHITKIAPSLPSVHMQDVAKAGGLSAVINEIAKFNSDLLSLDALTVSGESLGDRVKNAEILDESVIHTVQNAYSKVGGLAILFGNLAEQGCVIKAAGIIGSRQFSGKAVCFNSQDEAIKGISKGKVQKGDVVVLRYEGPKGGPGMQEMLSPTSLIVGRGLGADVALITDGRFSGATRGLSIGHVSPEAAEGGMIGLLKDGDIIDIDVDKFSINVRLSDTEIEARRKEWKYAGKPVNSRWLRQYQKLVTNASNGAILEA
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CUTC_BACFN
Sequence: MKNYLFEVCTNSVESCIAAQEGGANRVELCAGIPEGGTTPSYGEIAMAREVLTTTRLHVIIRPRGGDFLYSPVEVKTMLKDIEMARQLGADGVVFGCLTTNGGIDVPVMKQLMEASKGLSVTFHRAFDVCRDASEALEQIIDLGCDRILTSGQQATAELGIPLLKELRERANGRITLLAGCGVNEKNICRIAKETGIQEFHFSARESIKSGMEYKNEAVSMGGTVHISEYERNVTTVKRVKDTIESITSSL
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_CHLAD
Sequence: MGDNRWLKNSFVYLIILVAALALFFQYLGPGASQTEEKGIADVIADAQAGLVREIQAQAGDEQIIVTYNDGKKYRSRLESADSVMRLLADYGVPLRNEQGQRTINVIVQPAPAWGGLLSIFTILLPTLLLIGFFVFFMRQAQGSNNQAMSFGKSRARMFAGDKPTITFADVAGQEEAKQDLAEIVEFLKFPDKFAALGARIPRGVLMVGPPGTGKTLLSRAVAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFDQAKRNAPCIVFIDEIDAVGRQRGAGLGGSHDEREQTLNQILVEMDGFDTNTNVIVIAATNRPDVLDPALVRPGRFDRQVVLDAPDVRGRIEILKVHVKGKPLAEDVNLEILARQTPGFSGADLMNVVNEAAILAARRSKRKISMAEFQDAVERVAIGGPERRSRVMTDRQKLVVAYHEAGHAIVGAALPKADKVQKVTIIPRGQAGGYTLFLPDEDSLNLRTVSQFKARLAVSLGGRVAEEIVFGNEEVTTGASGDLVQVTRIARAMVTRYGMSQRLGPIVFGEKEELIFLGREISEQRNYGDEVARQIDEEVHAIVSEAYETAQQILLQNRAVLDDMANALIEYETLDGEQLEELIRRVKPLTLDFSKSGSTTPNGRTEDRPAQPDAPQMGLGGPSPLPA
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: FTSK_TROW8
Sequence: MSAKKSYLKVWRGLAGAAGSCARVFSKKSLARRDRRDQLPFALFLFGLVGAVFQWFLYGNWLSGIVSEYTVAAFFGGFSIVLPILLIGFSIWLFRNPQKTHDNIRVSIGLFMFSSFSAAFLHFSAGFPYPSSGIRILSTAGGIIGWLVGLPLTTLPSYLAKTVCIIFIVLSVSVISKTPISKIVRVIFRYAKWLFNSDSVKTSPNSSVSSSSEHQELTGRDMPDTAGDNRHDETVTVLSGTSLTGSPVSEYRGESSDYALPSLDILNSYPPVKHDDAENEKVITALSGVLRQFSVNARFSGFSRGPTVTQYELELGEGVKVERIIALTKNISYAVASDKVSILSPIPGKSAIGIEIPNKKRELVALGSVLQSIHPDAHPMTVGLGKDSSGGFVLTNLTTMPHLLVAGATGSGKSSFVNSMITSILLRAHPSQVRLVLIDPKRVELAIYSGVPHLITPIVTDPKKASEVLQWVVKEMERRYDDLASFGFRHIDDFNLAVRAKKIASDSRELTPYPYLLVIVDELADLMLVAAKDVEESIVRITQLARASGIHIVLATQRPSVNVVTGLIKANVPSRLAFAVSSLVDSRVILDRPGAEKLVGQGDGLFLPISAGKPIRIQSSWVTENEILRVVEYVKSQAHPDYYVLEVQNQGNIDSHIGDDMPLLLKATELVINSQLGSTSMLQRKLRVGFAKAGRLMDLMESMGIVGPGQGSKAREVLVTPQDLDSTLARISASVSDSKLD
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: KHSE_SYNPW
Sequence: MAQPRIGQTVVVDVPATTANIGPGFDCLGAALDLNNRFTMRRIEGDGERFELIIEGQEGSHLRGGAENLVYRAAQRVWKAAGEEPVALEARVRLAVPPARGLGSSATAIVAGLVGANALVGEPLSKEKLLELAIDIEGHPDNVVPSLLGGLCMTAKAASQRWRVVRCEWMHSVKAVVAIPAIRLSTSEARRAMPKTVPVGDAVVNLGALTLLLQGLRTGNGDLIADGMHDRLHEPYRWRLIKGGQEVRQAALEAGAWGCAISGAGPSILALCSEDKGPGISQAMVRAWESVGVASRAPLLNLQTTGSHWQPWDAG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAD1_CLOM2
Sequence: MEIKNGLCTQKYTKVYAEDKEKWKFNAPHHFIVGKADCEDEYIEPIEYVNFQEGPIKEYGINGVNNEDLILMVITRLQAFQDSPYKCRENAMAITKLQECLMWLGKRTLDREVKGIEGTSEI
What is the function of this protein?
Blocks activity of the Thoeris antiviral defense system (ThsA and ThsB) (PubMed:36174646).  Binds and sequesters the cyclic ADP-D-ribose signal molecule (cADPR) generated by ThsB (AC J8G8J6), ThsB' (AC J8CSK2, probably 3'cADPR), BdTIR (AC I1GTC2, 2'cADPR) and AaTIR (AC A0A1H7VGH3, 3'cADPR).  Sequestration prevents the signal from activating the Thoeris antiviral defense system; heating cmTad1 bound to the signal (95 degrees Celsius for 15 minutes) restores the ability of the signal to activate the NAD(+) hydrolase activity of ThsA (AC J8G6Z1) (PubMed:36174646).
What are the official names of this protein?
Thoeris anti-defense 1, cmTad1.
What is the protein family that this protein belongs to?
Belongs to the Tad1 family.
Protein: HDFR_SHIBS
Sequence: MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLHTVVDSTTLSRPLYAIWLQNSDKNALIRDLLKINVLDEVY
What is the function of this protein?
Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
What are the official names of this protein?
HTH-type transcriptional regulator HdfR, H-NS-dependent flhDC regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: SYA_STAA8
Sequence: MKKLKASEIRQKYLDFFVEKGHMVEPSAPLVPIDDDTLLWINSGVATLKKYFDGRETPKKPRIVNSQKAIRTNDIENVGFTARHHTFFEMLGNFSIGDYFKQEAIEFAWEFLTSDKWMGMEPDKLYVTIHPEDMEAYNIWHKDIGLEESRIIRIEGNFWDIGEGPSGPNTEIFYDRGEAYGQDDPAEEMYPGGENERYLEVWNLVFSEFNHNKDHSYTPLPNKNIDTGMGLERMASVSQNVRTNYETDLFMPIMNEIEKVSGKQYLVNNEQDVAFKVIADHIRTIAFAISDGALPANEGRGYVLRRLLRRAVRFSQTLGINEPFMYKLVDIVADIMEPYYPNVKEKADFIKRVIKSEEERFHETLEDGLAILNELIKKAKATTNEINGKDAFKLYDTYGFPIELTEEIAVQAGLKVDMTTFESEMQQQRDRARQARQNSQSMQVQSEVLKNITSASTFVGYDTATAQTTLTHLIYNGEEVSQVEAGETVYFMLTETPFYAISGGQVADTGIVYNDNFEIAVSEVTKAPNGQNLHKGVVQFGQVNVGATVSAEVNQNDRRDIQKNHSATHLLHAALKSVLGDHVNQAGSLVEADRLRFDFSHFGPMTNDEIDQVERLVNEEIWKGIDVNIQEMDIASAKEMGAMALFGEKYGDVVRVVNMAPFSIELCGGIHVRNTSEIGLFKIVSESGTGAGVRRIEALTGKAAFLYLEDIQEKFNTMKSQLKVKSDDQVVDKLTQLQDEEKALLKQLEQRDKEITSLKMGNIEDQVEEINGYKVLVTEVDVPNAKAIRSTMDDFKSKLQDTIIILASNVDDKVSMVATVPKSLTNNVKAGDLIKQMAPIVGGKGGGRPDMAQGGGTQPENISKSLSFIKDYIKNL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIFL_ECOL6
Sequence: MKNVFKALTVLLTLFSLTGCGLKGPLYFPPADKNAPPPTKPVETQTQSTVPDKNDRATGDGPSQVNY
What are the official names of this protein?
Uncharacterized lipoprotein YifL.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: 1104L_ASFWA
Sequence: MLVVFFLGILGLLANQILGLPTQAGGHLRSTDNPPQEELGYWCTYMESCKFCWECAHGICKNKVNKSMPLIIENSYLTSCEVSRWYNQCTYSEGNGHYHVMDCSDPVPHNRPHQLLKKIYEKEDL
What is the function of this protein?
Causes the redistribution of lumenal ER protein to an enlarged ERGIC compartment.
What are the official names of this protein?
Protein MGF 110-4L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 110 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment.