PharMolix/UniProtQA huggingface dataset:
Protein: FSHR_FELCA
Sequence: MTFLLVSLLAFLSLGSGCHHRICHCWHRVFLCQESKVTEIPSDLPRNAVELRFVLTKLRVIPKGAFSGFGDLEKIEISQNDVLEVIEANVFFNLSKLHEIRIEKANNLLYIDTDAFQNLPNLRYLLISNTGIKHFPAVHKIQSLQKVLLDIQDNINIHTVERNSFMGLSFESMILWLNKNGIQEIHNCAFNGTQLDELNLSDNINLEELPNDVFQGASGPVILDISRTRIHSLPSYGLENIKKLRAKSTYNLKKLPSLDKFVALMEASLTYPSHCCAFANWRRPISELHPICNKSILRQEVDDMTQARGQRVSLAEDEESSYTKGFDMMYSEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYDILRVLIWFISILAITGNIIVLMILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIYTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTVITLERWHTITHAMQLECKVQLRHAAIIMLLGWIFAFMVALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICCCYAHIYLTVRNPNIVSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEVQAQTYRSETSSTAHNFHPRNGHCPPAPRVTNSSNYILIPLRHLAKN
What is the function of this protein?
G protein-coupled receptor for follitropin, the follicle-stimulating hormone.  Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
What are the official names of this protein?
Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYFB_PROMM
Sequence: MRVPLSWLQDLVQLNETVEILAEGLSMAGFEVEAIDDLASHAQGVVVGLVKDHQPHPNADKLSVCQVDVGSGEGLQIVCGAPNVRIGIHVPVAMVGATLPAVGIKIKASELRGVPSQGMICSLAELGLESNGNGIAILEEIAENVPDLGQPVGPLLGLDDTVLELAITANRPDGMSMVGIAREVAALTGASLQLPQLDMAPIHKSFEPDSTSSASMLKGGLYGLTALENVDGELTSPAWLKQRLERSGCKSVNGVVDITNLVMLEQGQPLHAFDIDALEMITGQTVSAESFGLRQARNNELFNGLDGHQLQLNENCQIVTCHDIPIALAGVMGSAESGVSAKTRRVWLESAMFTPTAVRTTCRAVGLRTDASSRFEKGLPVEMTLASARRAVTLMEEHLGIKSNGCWVYGESPKSAEPVKLRREAIHRLLGPIGVENDNRYLEDDIIETSLLALGCELSPYNEGWLVIVPPSRRRDLSREVDLIEEVSRLVGFDRFEANLPDPLEPGGLTTAQTAERLLRQMLCGAGLQEVTTLSLVGADSDEPQRIAISNPLLAETSHLRTNLWEEHLRICQRNLQSSQPGCWLYEIGNVYTVTDELINQRAVLGGVICAERSFERWSTSGKIKSMTYHQARGQLSQVFQGLKLDINDRPLKDNHSLHPGRSAELFVEGKLLGDFGQLHPALSERLDLPEATYLFALDLQCIIQAATRSNRWNPTFRPFPTVPAMELDLAVIVSKECSCSDLIQAIRKAGKPLLEHVELIDRFEGGQLDPYSCSQAFRLRYRSKDRTLSEDKVNPIHEKVRQALVKQFSAELRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDM12_CRYNJ
Sequence: MSLDINWSLLSQPDESATDQLSESLIALLNAQLAEAHRPSFIGPITVTAFDFGNAGPDLEVKDIRDVWRVFDQGDDEGDFAEEEKQREKEREERDKLRNEALKSSLDGERYELVDRYSSTEGTSSFEYQPEYDIHEQHGDDYRIRGRRPLSYTFGYPHDRLAVHRSSSSRSFIPFPFDHPPPALHIPSTPGLNPSLVSHPISARFSRRPMSIAASAAPRPTPRRRPIEPSSTSPSPPAHPAGLPPKVSSSSIPSLQLHLRLSHASDLHLTLLTSLQVNYPSALFMALPLKLSITGFQLNADIVMAYSGEKNRVHLTIVDDESNPAHKEDKQIPLGQRLLSNLQIESEIGHADAHVLRNVGKVERFIVDVVRKTLVDELVFPNFHTVAL
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: RLMH_MYCMS
Sequence: MKIKILCFGKLDKKFYIDAFNDYFKRLKKYVDLEIIELKEEVNGELNKIKDENSNLLLKKLQNYKDFEKVVLDVNSRLISTENLVEIIKTNLNYKSAKILFIIGPSDGYSKSFLNSFTNKFSLAKITLPHQLCRIVLIEQIYRVFKIINNEKYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_OLEA2
Sequence: MPRKGPIPRREVLPDPVYNSRLAARFVNRMMVDGKKGAAEKIFYKSLEVLQEKTGEDAIKAFEKAVDNVKPFVEVKSRRVGGATYQVPVEVRSDRQVSLAIRWLITYARARGEKGMVGRLSGELLDAFNNRGGAVKKKDDTHRMAEANKAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RS18_GEOSW
Sequence: MAGRKGGRAKRRKVCYFTANGITHIDYKDVDLLKKFISERGKILPRRVTGTSAKYQRKLTVAIKRARQMALLPYVADE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TPS12_DICPU
Sequence: MYSLFKNIKFPNHWIPPIEFENKEQVKEKYFKRYCELGFYNENSIKDKVMNSSSVLLSYYFFSVAKNDQEFNLGYDIMAAFFSTDDFFDGKPENYNNQTAKERIFNIIKNEGNCSFSDFNQNEKFLIKYIIDSKEYSKNNSNKQILYYKILQGWIDYVESLGPYNLLENYSYNETIHLFIRRFDIAYLPACDLAIMMVIENLNISIMYHPKYCLMHLDLAKSLSLINDLHSFEKEFLDGQIKNNYLYKIIEKGNDNKSFDVGSFDIGVKKIFNDINKLNQSAENYEKELLEEFQLKLNEKQFDEFKKVITASLLINGGNLVWGNTNARYSTKNSIFIELKEKYEESCTTYLNTKSLFG
What is the function of this protein?
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpenes beta-elemene, valencene; alpha-selinene, 7-epi-alpha-selinene and a yet unidentified sesquiterpene.
What are the official names of this protein?
Terpene synthase 12.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: MUTS_RALSO
Sequence: MAEHSAPALEIDPKYGPFDKHTPMMQQYLKLKSAHPHTLVFYRMGDFYELFFEDAEKAARLLDITLTSRGTTNGQPIRMAGVPFHAVEQYLAKLVKLGESVAICEQIGDPATTKGPVERKVVRVVTPGTLTDAALLSDKVNNHLLAIAQIPGKRGAAPLVGLAWLNLVGGELRLMECSAEQLDRELERIRPAEVLADDATLNAVAFDVARTRLPDWHFDVEAGARRLREQLGVASLVAFGCETLTAALAAAGALLNYAAATQGQSLRHVIGLTVEHESEFIGLDTATRRNLELTETLRGQESPTLFSLLDTCATSMGSRLLRHWLHHPLRDRAVPQARQQAIEVLLAGDWQSLRGTLRTLSDVERITGRLALLSARPRDLSSLRDTLARLPEVRDQLPQSDDAQLLGDLHAALAIPEDAHALLQRAVMAEPAAMVRDGGVIARGYDADLDELRDISENCGQFLVDLEARERERTGIANLRVEYNRVHGFYIEVTNGQAAKVPDDYRRRQTLKNAERYITPELKAFEDKALSAQDRALSREKYLYEDLLQKLLPHLPVLKRIAAALAQADVLATLAERAHALSWSRPALTDAPGIELIRARHPVVEQQVEQFVANDCVLQETRKLLLITGPNMGGKSTFMRQTALVVLLAYVGAFVPADAATIGPIDRIFTRIGAADDLAGGRSTFMVEMTEAAAILHRATPNSLVLMDEIGRGTSTFDGLALAWAIARHLLSHNRSHTLFATHYFELTQLPQEFAQAANVHLSAVEHGDGIVFLHAVQEGPASQSYGLQVAQLAGVPQPVIRAARKRLAWLEQHSADTGATPQLDLFALPSDPSDDDAAEAAAPAAPSALAEALDGIDPDSMTPRDALDALYRLKALSDASA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RBL1A_METPP
Sequence: MNKPMEDAAITDVKKRYSAGVLKYRQMGYWMPDYVPKDTDTICLFRITPQDGVDPVEAAAAVAGESSTATWTVVWTDRLTACDSYRAKAYKVEPVPGIPGQFFAWVAYDIILFEEGSIANMTASLIGNVFSFKPLKAARLEDIRIPVAYVKTFKGPPTGLVVERERLDKFGRPLLGATTKPKLGLSGRNYGRVVYEGLKGGLDFMKDDENINSQPFMHWRDRYLYVMDAVNKASAATGEIKGSYLNVTAATMEDMYERAEFAKELGSVIVMIDLVIGYTAIQSMSNWARRNDVILHLHRAGHGTYTRQKNHGVSFRVIAKWMRLAGVDHIHTGTAVGKLEGDPMTVQGYYNVCRDSVTKQDLPRGLFFDQDWADLKKVMPVASGGIHAGQMHQLIDLFGDDVVLQFGGGTIGHPQGIQAGAVANRVALECMVKARNEGRDIKNEGPEILRKAAQFCAPLKQALDTWGEISFNYTPTDTSDYAVTPGVA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain 1, RuBisCO large subunit 1.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: G3P_CORGL
Sequence: MTIRVGINGFGRIGRNFFRAVLERSDDLEVVAVNDLTDNKTLSTLLKFDSIMGRLGQEVEYDDDSITVGGKRIAVYAERDPKNLDWAAHNVDIVIESTGFFTDANAAKAHIEAGAKKVIISAPASNEDATFVYGVNHESYDPENHNVISGASCTTNCLAPMAKVLNDKFGIENGLMTTVHAYTGDQRLHDAPHRDLRRARAAAVNIVPTSTGAAKAVALVLPELKGKLDGYALRVPVITGSATDLTFNTKSEVTVESINAAIKEAAVGEFGETLAYSEEPLVSTDIVHDSHGSIFDAGLTKVSGNTVKVVSWYDNEWGYTCQLLRLTELVASKL
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAOC_ECOLI
Sequence: MKFDKPAGENPIDQLKVVGRPHDRIDGPLKTTGTARYAYEWHEEAPNAAYGYIVGSAIAKGRLTALDTDAAQKAPGVLAVITASNAGALGKGDKNTARLLGGPTIEHYHQAIALVVAETFEQARAAASLVQAHYRRNKGAYSLADEKQAVNQPPEDTPDKNVGDFDGAFTSAAVKIDATYTTPDQSHMAMEPHASMAVWDGNKLTLWTSNQMIDWCRTDLAKTLKVPVENVRIISPYIGGGFGGKLFLRSDALLAALAARAVKRPVKVMLPRPSIPNNTTHRPATLQHLRIGADQSGKITAISHESWSGNLPGGTPETAVQQSELLYAGANRHTGLRLATLDLPEGNAMRAPGEAPGLMALEIAIDELAEKAGIDPVEFRILNDTQVDPADPTRCFSRRQLIECLRTGADKFGWKQRNATPGQVRDGEWLVGHGVAAGFRNNLLEKSGARVHLEQNGTVTVETDMTDIGTGSYTILAQTAAEMLGVPLEQVAVHLGDSSFPVSAGSGGQWGANTSTSGVYAACMKLREMIASAVGFDPEQSQFADGKITNGTRSATLHEATAGGRLTAEESIEFGTLSKEYQQSTFAGHFVEVGVHSATGEVRVRRMLAVCAAGRILNPKTARSQVIGAMTMGMGAALMEELAVDDRLGYFVNHDMAGYEVPVHADIPKQEVIFLDDTDPISSPMKAKGVGELGLCGVSAAIANAVYNATGIRVRDYPITLDKLLDKLPDVV
What is the function of this protein?
Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes.  It might play a role in the detoxification of aldehydes to avoid cell damage.
What are the official names of this protein?
Aldehyde oxidoreductase molybdenum-binding subunit PaoC.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y2677_KLEP7
Sequence: MKKKTSLSEEDQALFRQLMTGTRKIKQDTIVHRPQRKKITEVAPKRLLQEQVDNSHYFSDEFQPLLNTEGSTKYVRPDVSHFELKKLRRGDYSPELFLDLHGLTQQQAKQELGALIAACRREHVFCACVMHGHGKHILKQQTPLWLAQHPHIMAFHQAPKEYGGDAALLILIEVEEWQPPELP
What are the official names of this protein?
UPF0115 protein KPN78578_26770.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: RL4_AERHH
Sequence: MELVMKDAKSALEVSETTFGREFNEALVHQVVVAYAAGARQGTRAQLTRSEVSGGGKKPWRQKGTGRARAGSIRSPIWRSGGVTFAAKPQDHSQKVNKKMYRGAIRSILSELVRQERLIVVEKFGIEAPKTKELIAKLKEMELTDVLIVTAEVDENLFLAARNLYKVDVRDVAGIDPVSLIAFDKVLMTADAVKQIEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PP4P1_RAT
Sequence: MAADGERSPLLSEAGDGGAGGNGLAGPGGSATGPGGGLTPSAPPYGAGKHAPPQAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSPINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKPAQQYGGIYAAWAFVILLAVLCLGRALYWGCMKVSHPVQNFS
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity).  Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).  Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity).  Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity).  May play a role in the regulation of cellular cholesterol metabolism (By similarity).
What are the official names of this protein?
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase, Type 1 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase I, Transmembrane protein 55B.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: TCPA_MONDO
Sequence: MEGPLSVFGERTTGESIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSIIGGYRLACKEAVRYINENLIINTDELGKDCLINAAKTSMSSKIIGIDGDFFANMVVDAVLAVKYTDVKGQPRYPVNSINVLKAHGRSQKESMLINGYALNCVVASQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRKREADITKERIQKILATGANVILTTGGIDDMCLKYFVESMTIAVRRVLKRDLKRIAKASGATILSTLASLEGEESFEASMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLIIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVNGKPRDNRQTGVFEPTMVKVKSLKFATEAAITILRIDDLIKLHPESKDDKRGGTYEDAVHSGAIED
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.  The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.  As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.  The TRiC complex plays a role in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit alpha, TCP-1-alpha, CCT-alpha.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: PLSX_MESM1
Sequence: MKIIAFDVMGSDKGVGPAVLASINFVKKNLDYKIILVGDKTLITKYVSENERIEIYDEPLEVKKGENLKAVLSKTTSMSVAIDLVKDNKAEVVLSAGDSASYLALCVIKLKRLEGITRPAFMPIFPTILDDKKFVLLDVGANIEVDTEYLVQWAKLGSVFAKIMWNIDKPNVGILNIGTEDFKGFKYHQEANQILKEANLSEMNYKGFVEPRDILKGNFDVIVADGYGGNLVLKSLEGTVIDFSSLIKRKITSTFFRKIGALILKKSFKEIKEHLDYRNVGGAWVIGVNSIAVKAHGSSDEKAFKGAFNQIKIAVENNVIENFKEIL
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
Protein: ITPA_BOVIN
Sequence: MAASLAGKKIVFVTGNAKKLEEVIQILGDKFPCTLVAQKIDLPEYQGEPDEISIRKCQEAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLEGFQDKSAYALCTFAFSTGDPNEPVRLFRGRTMGRIVVPRGCRDFGWDPCFQPDGYEQTYAEMPKAEKNTISHRFRALLALQEYFSSLTPGVGDDHPSWGSGEG
What is the function of this protein?
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_SHEWM
Sequence: MAIGLIGRKVGMTRIFTEDGASIPVTVIEIAANRVTQVRTLETDGYRALQVTTGTKKANRITKPEAGHFAKAGVEAGRGLWEVRLADDEGEGIEVGAELNVDIFADVAKVDVTGQSKGKGFQGGIKRWNFHAQDMTHGNSLAHRSNGSIGQNQTPGRVFKGKKMSGHMGAERVTTQNLDVVRVDAERNLLLVKGAVPGATNGNLIIKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: AROC_HELPG
Sequence: MNTLGRFLRLTTFGESHGDVIGGVLDGMPSGIKIDYALLENEMKRRQGGRNVFTTPRKEDDKVEITSGVFEDFSTGTPIGFLIHNQRARSKDYDNIKNLFRPSHADFTYFHKYGIRDFRGGGRSSARESAIRVAAGAFAKMLLKEIGIVCESGIIKIGGIEAKNYDFNHALKSEIFALDEEQEEAQKTAIQNAIKNHDSIGGVALIRARSIKTNQKLPIGLGQGLYAKLDAKIAEAMMGLNGVKAVEIGKGVESSLLKGSEYNDLMNQKGFLSNHSGGVLGGMSNGEEIIVKAHFKPTPSIFQPQQTIDINNNECECLLKGRHDPCIAIRGSVVCESLLSLVLADMVLLNLTSKIEYLKTIYNEN
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: DER_SHESW
Sequence: MIPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAFLSGYEFIVVDTGGIDGTEEGIETKMAEQSLAAIEEADVVLFMTDARAGLTAADLSIAQHLRSREKTTFVVANKVDGIDADSACAEFWSLGLGEVYQMAASQGRGVTNMIEYALTPYAEAMGIERQGEEEVVDERQYTEEEAEAEQKRLQDLPIKLAIIGKPNVGKSTLTNRILGEERVVVYDEPGTTRDSIYIPMEREGREYVIIDTAGVRRRSKVHQVIEKFSVIKTLKAVEDANVVLLIIDAREGVAEQDLGLLGFALNAGRALVIAVNKWDGIDQGIKDRVKSELDRRLGFIDFARIHFISALHGTGVGHLFESIEEAYDSATRRVSTSMLTRIMQMSQDDHQPPLVNGRRVKLKYAHVGGYNPPIVVIHGNQVSRLPDSYKRYMMNYFRRSLKVVGTPIQLRFQEGDNPFENKTEKLTMSQERRRKRALSHIKDRKTK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ANEH_ASPA1
Sequence: MAVEQNIAPAKLIDRFSHDGPGKCRTSEWRFEVPLNHSKPDEGTVRLFARSIHCVLGVDDPELPWMLYLQGGPGLGCKTPLEYAWLPSILEKGYRVLFLDERGTGQSSPITAKTLAQQGDHKKQADLLKRFRADNIVRDCEAVRKHLYQDAPADQSKWSVMAASFGGFCAISYVSMFPNSLVEVFIGGGPCPMVNEPGQVIPRLFAVAARRNEVYYKKYPEDVGRVKRIIKYLKENKVALSKGTLTPERFQQLGVMLGLHGGIDYIHGVVQRTDNDLDMFKFLTAPTLDLIENSGMAHNVIYSLLQEPMYCQGKAGGWCADKCRKADPRFSLNERNAQIWFTGEAIFSDMFESYDELKDLKPVAELLARSSDWGQLYNEAQLARNEVPVYVATAVEDMYVSYDLGCHTASKVKNLQQVVNNTWYHDAVETKASEVMPALFALKEDRID
What is the function of this protein?
Proline iminopeptidase; part of the gene cluster that mediates the biosynthesis of aculenes, a unique type of norsesquiterpenes that contain a nordaucane skeleton linked to an L-proline moiety and are of mixed biosynthetic origin (PubMed:31618514).  The pathway begins with the synthesis of dauca-4,7-diene by the terpene cyclase aneC using farnesyl pyrophosphate (FPP) as substrate (PubMed:31618514).  The cytochrome P450 monooxygenase aneF then performs the initial oxidation at C-12 of dauca-4,7-diene to yield asperaculane D (PubMed:31618514).  Asperaculane D is substrate of the cytochrome P450 monooxygenase aneD for C-10 hydroxylation to yield asperaculane E (PubMed:31618514).  The cytochrome P450 monooxygenase aneG then converts asperaculane E into aculene D via C-2 oxidation (PubMed:31618514).  The monomodular nonribosomal peptide synthtase aneB adenylates L-proline and the thiohydrolase aneE transfers this activated L-proline derivative to aculenes D and C to produce respectively aculenes B and A (PubMed:31618514).  The dioxygenase aneA converts aculene D into aculene C, and aculene B into aculene A by introducing the 5,6-alkene moiety (PubMed:31618514).  Asperculanes A, B, C and F, as well as 14-prolyl asperculane C, might be shunt products of the pathway (PubMed:31618514).
What are the official names of this protein?
Proline iminopeptidase aneH, PIP, Aculenes biosynthesis cluster protein HA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUCS_CORK4
Sequence: MRLVIATCSVDYVGRLTAHLPKATRLLMVKADGSVSVHADDRAYKPLNWMTPPCTLTVHPIAIDDPDTDFTDGSSVGNSEEQGTDGSAHTAHEEELWVVENKKGEQLRITVHDKISDTTYDLGEDPGLTKDGVEAHLQELLAQHPEALGEGFTLVRREYPTPIGPVDILTRDASGKTVAVEVKRRGGIDGVEQLTRYVELLNRDEILAPVQGLFAAQEIKPQARTLAEDRGFTCVTVDYDELRGTPSQELRLF
What is the function of this protein?
Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
What are the official names of this protein?
Endonuclease NucS.
What is the protein family that this protein belongs to?
Belongs to the NucS endonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCAL_CERS5
Sequence: MSFRLQPPPPARPNRCQLFGPGSRPALFEKMAASAADVVNLDLEDSVAPDDKAQARLNIIEAINTLDWGKKYLSVRINGLDTPFWYRDVVDLLEQAGDRLDQIMIPKVGCAADVYAVDALVTAIERAKGRTKPVSFEVIIESAAGIAHVEEIAAASPRLQAMSLGAADFAASMGMQTTGIGGTQENYYMLHEGQKHWSDPWHWAQAAIVAACRTHGILPVDGPFGDFSDDEGFRAQARRSATLGMVGKWAIHPKQVALANEVFTPSDKAVAEAREILAAMEAAKARGEGATVYKGRLVDIASIKQAEVIVRQAEMISA
What is the function of this protein?
Involved in the ethylmalonyl-CoA pathway for acetate assimilation.  Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to yield beta-methylmalyl-CoA (By similarity).
What are the official names of this protein?
L-malyl-CoA/beta-methylmalyl-CoA lyase, (3S)-malyl-CoA/beta-methylmalyl-CoA lyase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.