PharMolix/UniProtQA huggingface dataset:
Protein: CRFA2_CONTE
Sequence: MSGRGFLLLALLLLVTVEATRVEKKHSGILLAWSGPRNRFVRIGRRDMQSPLLSERLRFRALGFRQPSSQKQ
What is the function of this protein?
This peptide activates human sensory neuron-specific G-protein coupled receptors MRGPRX1, but not mouse receptors (EC(50)=0. 54 uM) (PubMed:30243794).  Compared with the agonist chloroquine (anti-malaria drug), it is 600-fold more potent (PubMed:30243794).  In vivo, induces itch sensation, since intradermal cheek injection into humanized transgenic mouse (mouse MRGPRX1 replaced by human MRGPRX1) induces scratching (PubMed:30243794).  In vivo, treatment of zebrafish larvae with high doses (10 uM) induces hypoactivity at the beginning of the experiment during the dark phase and hyperactivity in the strobe phase after one hour, even after the removal of the toxin from the solution (PubMed:33764053).
What are the official names of this protein?
Conorfamide-Tx2, CNF-Tx2, Cono-RFamide-Tx2.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: URE1_LARHH
Sequence: MSTISRQQYADLFGPTTGDKIRLGDTSLFVSIEKDLRTYGDEAVYGGGKTLRDGMGMDNELTSIGGAPDLLITNVTIIDAVLGVIKADVGIKDGRICGIGKAGNPSTMPGVTPSLAVGPATDAISGEHLILTAGGIDAHVHMISPQQAEAALSNGITTLFGGGLGPTDGTNGTTITSGTWNLEMMMRSFDALPINVGLLGKGNSSGMKPIVEQIEAGAAGLKVHEDWGSTVGAIRTSLEAADEYDVQVAIHTDTLNEGGFVENTIAAFDGRTIHTYHTEGAGGGHAPDIIRVASYSNVLPSSTNPTLPFGINSQAELFDMTMVCHNLNPKVATDVAFAESRVRPETIAAENVLHDMGVISIISSDSQAMGRVGESWARSIQTADAMKQGRGKLPEDNADDDNFRVLRYVAKITINPAIAQGISHLVGSVEVGKFADLVLWEPAFFGAKPKFVIKGGMIAWSLMGDPNASLPTPQPVIYRPMYGAFASALHKTCITFASQAGVANGIAERYGLQRLVEPVRNTRAITKNDMVRNAHTPHIEVNPETFAVMVDGVHATVAPIRSVSLGQLYFFS
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_VIBA3
Sequence: MNTEKISLIKASIKSIPDYPKAGILFRDVTSLMEDPAAYKATIDLLVDTYKGMGFTKIVGTEARGFLFGAPLALELGVGFIPVRKPGKLPRQTVAQSYELEYGTDTLEIHTDAIVEGDKVLMVDDLLATGGTIEATTKLIRQLGGVVEHAAFVINLPEIGGDKRLQGLGLEVFSICEFDGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP7_ROTHO
Sequence: MYGIEYTTVLTFLISVILLNYVLKSLTRIMDFIIYRFLLIIVILSPFLNAPNYGINLPITGSMDTPCTNSTREEVFLTSTLCWYYPTEAATEINDNSWHGTLSQLFLTKGWPTGSIYFKAYTNIASFSVDPQLYCDYNLVLMKYDATLQLDMSELADLLLNEWLCNPMDITLYYYQQTDEANKWISMGSSCTIKVCPLNTQTLGIGCLTTDTNTFEEVATAEKLVITDVVDGANHKLNVTTNTCTIRNCKKLGPRENVAVIQVGGSDILDITADPTTAPQTERMMRVNWKKWWQVFYTIVDYVNQIVQAMSKRSRSLNSAAFTNRI
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: SSPN_BACVZ
Sequence: MGINKKDGQPQYAPSHLGTKPVKYKRNKGEKFHDKSNGHPIVMQTKGE
What are the official names of this protein?
Small, acid-soluble spore protein N, SASP N.
What is the protein family that this protein belongs to?
Belongs to the SspN family.
What are the subcellular locations of this protein?
Spore core.
Protein: VF199_ASFK5
Sequence: MSCTPVSTKCNDIWIDFSCTGPSVSELQKKEPNAWAAILRSQKNQQTAEDDTIIGSICDKQGLCSKDEYAYSQYCACVNSGTLWAECAFAPCNGNKNAYKTTEQRNILTNKQCPSGLTICQNIAEYGGTGNISDLYQNFNCNSVINTFLINVMNHPFLTLILIILILVIIYRLMSSSAAKQNGDKLPPPSLIFSNLNNF
What is the function of this protein?
Essential for viral fusion with host endosomal membrane and core release (By similarity).  Not required for virus morphogenesis and egress (By similarity).  Induces complete autophagy through the interaction with and down-regulation of host PYCR2 (By similarity).
What are the official names of this protein?
Inner membrane protein E199L, pE199L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus E199L family.
What are the subcellular locations of this protein?
Virion membrane. Host membrane; Single-pass membrane protein. Note=Found in the perinuclear cytoplasmic viral factories during assembly (By similarity). Part of the virion inner membrane (By similarity).
Protein: RS12_BIFLS
Sequence: MPTIEQLVRKGRQAKPKKSKTLALKGSPLRRGVCTRVYTTTPRKPNSALRKVARVRLSSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGALDTQGVKDRKQGRSLYGAKKAK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: NU3M_NEUCR
Sequence: MRSMTLFILFVSIIALLFLLINLVFAPHIPYQEKNSEFECGFHSFHQTRFPFDSPIAAQAICFVILDLEIFTMFPYVGSLGINTFYSLVVILGFMFVVSAGFVFELGKGALKIDSKQNMGGDSTHLELKNLKDISSLNLCPPSAFKN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane.
Protein: H13A5_CYRHA
Sequence: MKTAIFTVVLALAVFAVLSFGWEANEKALSEESTELIHEKEAASETEARECRYFWGECHDHMPCCDWLVCRYKWPITYNICVWNRTFPEK
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U7-theraphotoxin-Hhn1a 5, U7-TRTX-Hhn1a, Hainantoxin-XIII.5, HNTX-XIII.5.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 13 (Hntx-13) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS10_METMA
Sequence: MQKARIRLSGISPKDLDGVCNQVKSIAERTGVNISGPVPLPTKKLVVPTRKSPSGDGTATWDHWEMRVHKRLIDIAADERALRQLMRIQVPKDINIEIVLEG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: HMF1_YEAST
Sequence: MVTTLTPVICESAPAAAASYSHAMKVNNLIFLSGQIPVTPDNKLVEGSIADKAEQVIQNIKNVLEASNSSLDRVVKVNIFLADINHFAEFNSVYAKYFNTHKPARSCVAVAALPLGVDMEMEAIAAERD
What are the official names of this protein?
Protein HMF1, High dosage growth inhibitor, Homologous mitochondrial matrix factor 1.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion intermembrane space.
Protein: RIMP_STAA2
Sequence: MSKITEQVEVIVQPIMEDLNFELVDVEYVKEGRDHFLRISIDKEGGVDLNDCTLASEKISEAMDANDPIPEMYYLDVASPGAERPIKKEQDFQNAITKPVFVSLYVPIEGEKEWLGILQEVNNETIVVQVKIKARTKDIEIPRDKIAKARHAVMI
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_BACAH
Sequence: MGQKVNPIGLRVGVIRDWESRWFAEKDYATLLHEDIKIREYINVRLKDSAVAKVEIERAANRVNVTIHTAKPGMVIGKGGTEVEALRKALNQLTGKRVHINILEVKRADLNAKLVGENIARQLENRVSFRRAQKQVIQRAMRAGAKGIKTQVSGRLGGADIARAESYSEGTVPLHTLRADIDYAAVEADTTYGKLGVKVWIYRGEVLPTKKKASEEGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: DMS1_PHAJA
Sequence: GLWKNMLSGIGKLAGQAALGAVKTLV
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Dermaseptin-J1, DRS-J1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VATL_SOLLC
Sequence: MSNFAGDETAPFFGFLGAAAALVFSCMGAAYGTAKSGVGVASMGVMRPELVMKSIVPVVMAGVLGIYGLIIAVIISTGINPKTKSYYLFDGYAHLSSGLACGLAGLSAGMAIGIVGDAGVRANAQQPKLFVGMILILIFAEALALYGLIVGIILSSRAGQSRAE
What is the function of this protein?
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase 16 kDa proteolipid subunit, V-ATPase 16 kDa proteolipid subunit, Vacuolar proton pump 16 kDa proteolipid subunit.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase proteolipid subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: ATP8_HYLLA
Sequence: MPQLNTTVWPTIIMSMLLALFLLMQLKTLNTHYHPPASPKLTNIKPHNNPWEHKWTKIYSLHSLPPQF
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: RS9_SYNJA
Sequence: MTQAASSQRAVYWGTGRRKTAVARVRLVPGTGKLIINDRPGDQYLQYQEALLASVKAPLELLGLENSYDILVRAHGGGVHGQADAIKLGVARALCEVDPANRGPLKTEGYLKRDPRAVERKKYGLRKARKAPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: DF229_ARATH
Sequence: MKSTTLFMVSCVLIFCVLSHVREVKSVETKAKRVKKVCEKAQVFEQNCGWDGNKTCIRGFNKIKEYPFHCECGIYDAPNSRRICKCKFPYSPC
What are the official names of this protein?
Defensin-like protein 229, S locus cysteine-rich-like protein 27, Protein SCRL27, SCR-like protein 27.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: HISZ_NOSS1
Sequence: MVYQPAAGARDLLPLDVAQKRWIEDKLQQVFHRWGYHRIITSTLERMDTLMAGEAIQRQMVIQLQNSEDEELGLRPELTASIARAVVTRMANLRHPQRLYYNANVFRRIWENRHNRQQEFYQAGVELLGVGGLLANAEVLLLAGNCLTALGLQDWHLILGEAGITRSLLDAFPINLRAKVRSAIAHLDRITIDTLPLTDELRERARIMLDLRGNSADVLQKVSSLNLDAEQQEAVNNLKSLVELLESGGKFPIILDLSLIQTIDYYTGLVFEIVNNTDSQARVLGRGGRYDQLLGLYHPQGENIPGIGFVLNIEDLYQVLLSTQQLPQETPASDWLVVPENPAAHSAAFAYAQKLRESPDLVRVELDLGSTDRATIKQYARDRSIAQIAWIKADGSPIIEKVSQ
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_BIFLO
Sequence: MAELTIDPASIRKALDDFVSSYKPSDTPTQEVGYVATAGDGIAHVTGLPGCMANELLTFEDGTLGLAFNLDAREIGVVILGDFAGIEEGQEVRRTGEVLSVPVGDGYLGRVVDPLGKPLDGLGEIQGIEGRRILEAQAPDVMHRHPVDEPLSTGLKAIDAMTPIGRGQRQLIIGDRQTGKTAIAIDTIINQKANWESGDPKKQVRCIYVAIGQKGSTIASVKQSLEDAGAMEYTTIVASPAADSAGFKYIAPYTGSAIGQHWMYNGKHVLIVFDDLSKQAEAYRSISLLLRRPPGREAYPGDVFYLHSRLLERCAKVSDDLGGGSMTGLPIVETKANDVSAYIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGAAQTKALKKVSGTLKISLAQYRSLESFAMFASDLDAASKAQLTRGAHLTELLKQPQFHPYSPEQEVVSVWTGTHGKLDDLDLKDVLPFEQGLLDYIDHNTDILKTIRETEEFTADTEAALDKAVDEFRSTFVSSAGKPLVEKKPDVDKAAPVDQEKIVAGEK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL22_GEOSM
Sequence: MESSAKLSSVRLSPRKTRLVVDLVRGKGIQTALNTLRFSPQPSAKLISKLLSSAVANAEQKGCSDVDKLFVKTIFVDGGAVLKRFTPRAMGRASKIRKPTSHITVVLAEKK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: ASNA_ECO8A
Sequence: MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEERLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLQLEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_FRATW
Sequence: MNIRPLQDRVLVRRAEEEKKSAGGIILTGSAQEKPSQGEVVAVGNGKKLDNGTTLPMDVKVGDKVLFGKYSGSEVKVGDETLLMMREEDIMGIIA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB175_ARATH
Sequence: MTMTTTISHLPTELLDEIISRVPLKSTRAVRLTCKNWDSLFKNRSFMKEEAAAKEGESRMIVLMDKNLFAMSIFFNGIDIDPSAEQRGKLTCLYDDSEQVKISQVFHCEGLLLCVLEDDKCSLVVWNPYWGQTRWIEPRYFSRIQNCYGRYMYVYALGYNNKSRSHKILRFIDGAFDFPFWYEIYDFDSDLWTTLDVTPQWFINFPPRGCYNRGVTLKGNTYWCAIRRKSNTNWFVDLDHIICFDFTSERFGPLMPLPFVRYTSGSLVTLSCVREEKLAVLFCNNATVEVWITTKIETDKISWSKFLTVNMYVDLLEGSFFIDEVKKVAMIFDIPMNRETVYIVGEAGNVKELHLGQPVDVDKHFSPLFVCSYVPSLVQIKQPPGCQRKQESSLEKRRCDDENISRLIAHEETYVVYGRYVPSRKKPR
What are the official names of this protein?
Putative F-box protein At3g22421.
Protein: RLME_JANSC
Sequence: MVKKTSGRGQRDLKVKVKTARGRKLSSTRWLERQLNDPYVAAARRDGYRGRAAYKIIDLDDKYRFLVPGARVVDLGCAPGGWCQVAVKRVNALGEKSGKAVGRIIGLDLQEMEPIAGCELHQLDFMEDDADLKVKDWLGGRADVVMSDMAASASGHKQTDHMRIMALCEAAAELAFDVLEPGGTFVAKVLAGGAEGTLQRLLKQRFKKVANVKPGASRADSSEKFVVATGFRGRDEA
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPOD2_DROME
Sequence: MTNRLETKYENLSSIFRLKGHDYQKQFFHLYAHRLAEMTRLLTPLAQKKWGNKEPIKKLCELRGEQDVHCILIGTIFKHQAHKPSILRDISEENQLAPQPPRQNYSDPEDKIVLEDELQRVRLQGKLNGQLLATGVVCAALGGTDSDGFFNVEDILFYESGPQKPLAPIKRSRLLVLASGLDQLQAHKFVEALNLFQYWLAGSLGNNKEAGSMVRLIVAGNSVRASAMAHVPTLQVARTQANANDTVQAVSQLDQWFASWARSLPVDIMPGPYDPANFMLPQQPFHKCMFPQAAQLATFQAVTNPYSCRLDEALVVGTSGQNVSDLLRSTSLDSALEALRCTLTWGHVAPTAPDTLACYPYIESDPFILRECPHVYYAGNCESFATELHEGSEGKRTRLVCVPSFSKTQSVAVVDLDTLDCRMVNFSVDAE
What is the function of this protein?
Accessory component of both the DNA polymerase delta complex and possibly the DNA polymerase zeta complex (By similarity).  As a component of the delta complex, participates in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (By similarity).  Appears to promote the function of the DNA pol-delta complex accessory subunit PolD3 in both embryonic and postembryonic somatic cells (PubMed:31100062).
What are the official names of this protein?
DNA polymerase delta subunit 2, Pol31 polymerase delta subunit.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase delta/II small subunit family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Note=In embryos, accumulates in the nucleus during interphase but disperses into the nucleoplasm at the onset of mitosis.
Protein: UVRB_LEPBA
Sequence: MANFKMVSPFKAAGDQVKAIENIAKSFGEGKNKITLVGVTGSGKTFTMAEVITRVKKPTLILSHNKTLAAQLFREFKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDMSMNEEIDKLRLRATSSLLERDDVIIVSSVSCIYGLGSPEDYMNSVVMLQVGDKIDRDQIIRKFLHIQYARNDIDFSRGNFRVRGDTIEIMPSYQEEGIRIELFGDEIDGLSKIDPLTGKVKIKLDRVVVYPAKHFITSGPKIKDAMEKIKEEMAAQKEYFLKQGKHLEAERIESRTNYDMEMLLELGYCSGIENYSRHLTGRAEGERPACLLDYFPGKDFLLIIDESHVTLPQIGGMYAGDRSRKQTLVEFGFRLPSALDNRPLNFTEFEAMTPRTLYVSATPDQNELNKSEAVFEQIIRPTGLLDPVVEVRPTTNQIEDLLNEIRLRINQKERVLITTLTKKMSEDLTDYYKEVGLKIAYLHSEIDTIERTEIIRDLRKGVYDCIVGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLVQTIGRAARNVNGKAILYADRMTDSIKKAMSETERRRLIQEAHNEKMGITPQTIQKEIHDILPREMAEEDSKEEALKDLEKEFTLKKYKTKDKLREALKREMLRYANDMDFEKAAMFRDKMLALGPDKIET
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPE_BURVG
Sequence: MSATLALTEQLIARASVTPDDQHCQQIMTERLAALGFECETIASHGVTNLWAVKRGTAGRDGKLLAFAGHTDVVPTGPLEQWTSPPFIPAHRDGKLYGRGAADMKTSLAAFIVASEEFVAAHPDHRGAIAFLITSDEEGPATDGTVKVVELLDARGEQLDYCIVGEPTSSAELGDVVKNGRRGSMSGELIVKGVQGHIAYPHLAKNPIHLLAPALAELAAEQWDAGNEYFPPTTWQVSNLRAGTGATNVIPGHADLMFNFRFSTASTVEGLQARVHAILDKHGLDYTLKWSVSGLPFLTPRGELSNALEHAIRAETGVTTELSTTGGTSDGRFIARICPQVIEFGPPNGSIHKIDEHIELRFVDPLKNVYRRVLEQLIA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: GH317_ARATH
Sequence: MIPSYDPNDTEAGLKLLEDLTTNAEAIQQQVLHQILSQNSGTQYLRAFLDGEADKNQQSFKNKVPVVNYDDVKPFIQRIADGESSDIVSAQPITELLTSSGTSAGKPKLMPSTAEELERKTFFYSMLVPIMNKYVDGLDEGKGMYLLFIKPEIKTPSGLMARPVLTSYYKSQHFRNRPFNKYNVYTSPDQTILCQDSKQSMYCQLLCGLVQRSHVLRVGAVFASAFLRAVKFLEDHYKELCADIRTGTVTSWITDSSCRDSVLSILNGPNQELADEIESECAEKSWEGILRRIWPKAKYVEVIVTGSMAQYIPTLEFYSGGLPLVSTMYASSECYFGINLNPLCDPADVSYTLLPNMAYFEFLPVDDKSHEEIHFATHSNTDDDDDALKEDLIVNLVNVEVGQYYEIVITTFTGLYRYRVGDILKVTGFHNKAPQFRFVQRRNVVLSIDTDKTSEEDLLNAVTQAKLNHLQHPSSLLLTEYTSYADTSSIPGHYVLFWELKPRHSNDPPKLDDKTMEDCCSEVEDCLDYVYRRCRNRDKSIGPLEIRVVSLGTFDSLMDFCVSQGSSLNQYKTPRCVKSGGALEILDSRVIGRFFSKRVPQWEPLGLDS
What is the function of this protein?
Catalyzes the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin.  Strongly reactive with Glu, Gln, Trp, Asp, Ala, Leu, Phe, Gly, Tyr, Met, Ile and Val.  Appears to favor Glu over Asp while the other GH3 favor Asp over Glu.  Little or no product formation with His, Ser, Thr, Arg, Lys, or Cys.  Also active on pyruvic and butyric acid analogs of IAA, PAA and the synthetic auxin naphthaleneacetic acid (NAA).  The two chlorinated synthetic auxin herbicides 2,4-D and 3,6-dichloro-o-anisic acid (dicamba) cannot be used as substrates.
What are the official names of this protein?
Indole-3-acetic acid-amido synthetase GH3.17, Auxin-responsive GH3-like protein 17, AtGH3-17.
What is the protein family that this protein belongs to?
Belongs to the IAA-amido conjugating enzyme family.