PharMolix/UniProtQA huggingface dataset:
Protein: 3L22A_OPHHA
Sequence: MKTLLLTLVVVTIVCLDLGYTLLCYKTPSPINAETCPPGENLCYTKMWCDAWCSSRGKVIELGCAATCPSKKPYEEVDCCSTDNCNPHPKLRP
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Alpha-elapitoxin-Oh2a, Alpha-EPTX-Oh2a, Long chain neurotoxin.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1747_RHOPA
Sequence: MTVFAAEQQFHDAERPLPSHQARLACRAGLAETTAGVAPGFVQGNLAILPEKYAAAFHRFCQLNPKPCPIVGMSDVGNPMIPSLGIDLDIRTDLPRYRVWRDGELVEEPTDIVAHWRDDLVAFVIGCSFSFEEALLADDIPIRHIEEKVRVPMYRTNIPCAPAGPFSGPMVVSMRPLKPKDAIRAIQITSRFPSVHGAPVHIGLPQSIGIADIAKPDYGDPVPIGPDELPVFWACGVTPQAVIAAAKVPFAITHAPGLMLVTDLKNKHLAVL
What are the official names of this protein?
Putative hydro-lyase RPA1747.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: LGT_BRUO2
Sequence: MIETLLPASALAFPAIDPVIFRVGPLAVHWYGLGYVVGILFAWWYGKKLLRSHRLWANNQPPMAPEALDDFVIWAALGVVLGGRIGYVLFYNFSYYISNPLAIPALWDGGMSFHGGILGTTLAMILFARSRGILVWSMFDTIAAGVPIGLGVVRVANFINSELWGRVSDVPWAVYFPNGGPLPRHPSQLYEAFLEGLVLFFVLFVLVWGARKLKQPGFVAGAFVTGYGLSRIAVEFFREPDAQIGYLFGGWLTMGMVLSVPMVLLGLWAMWRANRAAARNA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GYRA_NICBE
Sequence: MKLHTLNPQTPLTQSKPMAFSTGITPSRFSGLRKTSSELRFLSSVTPPPRKQLRPVSARRKEEEVGDEGNGSVILRDRGENEDRNGGERVVLTELHKEATEAYMSYAMSVLLGRALPDVRDGLKPVHRRILYAMHELGLSSKKPYKKCARVVGEVLGKFHPHGDTAVYDSLVRMAQDFSLRSPLIRGHGNFGSIDADPPAAMRYTECRLEALTESMLLADLEQNTVDFVPNFDNSQKEPSLLPARVPNLLLNGASGIAVGMATNIPPHNLGELVDALSALIHNPEATLQELLEYMPGPDFPTGGIIMGNIGILEAFRTGRGRVVIRGKTDIELLDSKTKRAAIIIQEIPYQTNKASLVEKIADLVENKILEGVSDIRDESDRSGMRIVIELKRGSDPAIVLNNLYRLTALQSSFSCNMVGILNGQPKLMGLKELLQAFLDFRCSVVERRARFKLSQAQERNHIVEGIIVGLDNLDEVINTIRKASSNALAAASLRKEFELSEKQAEAILDISLRRLTALERNKFVEEGKSLRTQISKLEELLSSKKQILQLIEEEAIEIKNKFFNPRRSMLEDTDSGDLEDIDVIPNEEMLLAISEKGYVKRMKPDTFNLQNRGTIGKSVGKLRVNDAMSDFLVCRAHDKVLYFSDKGTVYSSPAYKIPECSRTAAGTPLVQILSLSDGERITSIIPVSEFAADQYLVMLTVNGYIKKVSLNYFASIRCTGIIAIQLVPDDELKWVKCCSNNDFVAMASQNGMVILTPCANIRALGRNTRGSVAMRLKEGDKVASMDIIPDALQKELDKTLEVQQRQYRSMKGPWLLFVSESGYGKRVPVSRFRTSPLNRVGLFGYKFSSEDCLAAVFVVGFSLGEDGESDEQVVLVSQSGTVNRIKVRDISIQSRYARGVILMRLEHAGKIQSASLISAADADPEDEDATAVAA
What is the function of this protein?
A type II topoisomerase that seems to play a critical role in chloroplast nucleoid partitioning by regulating DNA topology.  DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A, chloroplastic/mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion.
Protein: SYM_SALSV
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSDENRELSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSADQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTTSFEEYWKKDSDAELYHFIGKDIVYFHSLFWPAMLEGSHFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLKHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLAAELADPQLYKTFTDAAVVIGEAWESREFGKAIREIMALADVANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPTLSERVEAFLNSELNWDAIEQPLLGHKVNTFKALYNRIDMKQVEALVEASKEEVKAAAAPVTGPLADFPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRQTVMVANLAPRKMRFGVSEGMVMAAGPGGKDIFLLSPDDGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_VESOH
Sequence: MAKTLYNKLMDAHIIRENISTALIYIDRHLIHEVTSPQAFEGLSIANRKLWRKSTNLAVPDHNVPTTNRSSGVSSISDPISRIQIETLGRNCELFGIDEISMNDTRQGIVHIIGPEQGATFPGMSIVCGDSHTSTHGALGALAFGIGTSEVEHVLATNCLWQSKSKNFNIEVNGSLNQHVSAKDIALYIIGQLGTAGGMGFAIEFSGNTIQNLSIEGRMTLCNMAIEAGARIGMVAVDEKTINYVKDRPLAPSGIKWRKAVKYWRTLHSDKNAHFDKTMHFDAKDIKPQVTWGTSPDMVVATDGYVPNPNNAKNQTEKISWKNALNYMHLNANTKISDIKIDKIFIGSCTNSRIEDLRIAADILKDKKIANNIKLALVVPGSGIIKKQAEEEELDKIFINSGFEWREAGCSMCLAMNADKLEVGERCASTSNRNFEGRQGQGSFTHLVSPAIAASSAIAGYLSEVK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: GIN1_BOVIN
Sequence: MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFVFKEKKKVLRECHENDTGAHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKNTVILAPKQHLLKVENPWSIVTVDLMGPFHTSNRSHVYAIIMTDLFTKWVVILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIHQINVELCELFGTKQIVISHASQTINPAESTPSTIKTFLSKHCVDYPNDWDDHLPAVSFAFNVTHLEPTKNTPYFQMFNRNPYMPESSDIREVDGDNTSMFAKILDAIKEADKIMENKTTSVGQMENNNCHELNKSKIIVKKKPKQQNPFHLKVGHEVLRQRKNWWKDGRFRSEWVGPCVIDYITENGGAVLRDSSGARLKRPIKMSHLKPYVRESGEQDSLHLLHGSVVADHDYVGMPELPVGAYQASILVEDAAIGVDDSELLTSSKDRELLEYRNAKISPLMEDHNALEKQTFSLLDSSNQVLEYLT
What are the official names of this protein?
Gypsy retrotransposon integrase-like protein 1, GIN-1.
Protein: MDH_SHEPC
Sequence: MKVAVLGAAGGIGQALALLLKTQLPAGSKLSLYDIAPVTPGVAVDLSHIPTAVEIKGFAGEDPTPALVGADVVLISAGVARKPGMDRSDLFNINAGIVRNLIEKVAATCPKALVGIITNPVNTTVAIAAEVMKKAGVYDKNRLFGVTTLDVIRSETFIAELKGLNVADVKINVIGGHSGVTILPLLSQVEGVTFSDEEVASLTKRIQNAGTEVVEAKAGGGSATLSMGQAACRFGMSLVRGLQGEANVVECAYVDGGSEHAEFFAQPVLLGKNGIEKVLPYGEVSAFEANARDSMLDTLKGDIKLGVDFVK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: SWT16_ORYSJ
Sequence: MADPSFFVGIVGNVISILVFASPIATFRRIVRSKSTEEFRWLPYVTTLLSTSLWTFYGLHKPGGLLIVTVNGSGAALEAIYVTLYLAYAPRETKAKMVKVVLAVNVGALAAVVAVALVALHGGVRLFVVGVLCAALTIGMYAAPMAAMRTVVKTRSVEYMPFSLSFFLFLNGGVWSVYSLLVKDYFIGIPNAIGFALGTAQLALYMAYRRTKKPAGKGGDDDEDDEEAQGVARLMGHQVEMAQQRRDQQLRKGLSLSLPKPAAPLHGGLDRIIKSFSTTPIELHSILHQHHGGHHHHHRFDTVPDDDDEAVAAGGTTPATTAGPGDRH
What is the function of this protein?
Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
What are the official names of this protein?
Bidirectional sugar transporter SWEET16, OsSWEET16.
What is the protein family that this protein belongs to?
Belongs to the SWEET sugar transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IRO1_CANAL
Sequence: MLDRLNRKQSKERFVNKIPISTTKIDKSLEHTRRDDESNNAKRGVNPDESYSSDTSFTPTVVSGTEDAALTRTSTNRQRQGKSSFKSFFRTMSLKVNSKTRNKDRKTKEELAAEKALAELRNLPRNPLDLELNELHVASNFNEVRKIIDDIFIDENHDAASKAIRISTQNKSFSAMEKPYSLTKIKSLQTEDDYSLPITSFIIETLEENSIHADLSHNDNAITSTDILIEEEEEMEQEEEEEMLNYDDLDVISDKIDEVGAESSISTSNDRGIIANATANGPIIVGDSTESVDTSNIENRKLVVVNSTPDDHDYYATNDMNDNFITPNPSNESVETLAGVYKDFEVTNATEANTEAGKTTDINAETSNAIDAVADTENKVTAEDDATDTVNTGESMTDTTTSTTDNKNDKEVDKEVENAVDSNVTTNDTIPDKAANIDNESSSDNSIDATTANTTNTNNFNDAEVNTEATNTIVDNVTNDKFNSVDVSTTTPTATTVSGIPTADEMTNNVNTNRISTATVDSFTGKTGENYESFITNAGKDSNDNNADLKTPTNNSATTTTNTQSGVSNKKSNSKTGSSEQNPFQKKLMNYLNSLN
What is the function of this protein?
Transcription factor involved in iron utilization and virulence.
What are the official names of this protein?
Transcription factor IRO1, Iron utilization protein 1.
Protein: NEF_SIVM1
Sequence: MGGAISKKRSKPPRDLRQRLLRARGENYGRLFKGVEDGSSQSLGGLDKGLSSLSCEGQKYNQGEYMNTPWRNPAEERKKLPYRKQNIDDIDEEDDDLVGIPVEARVPLRTMSYKLAIDMSHFIKEKGGLEGIYYSARRHRILDIYLEKEEGIIPDWQIHSGPGIRYLKMFGWLWKLIPVNVSDEAQEDEEHYLVHPAQTSQWDDPWGEVLAWKFDPTLAYTYEAYIRYPEEFGSKSGLSEKEVKRRLAARGLLEMADRKETS
What is the function of this protein?
Interferes with TCR signaling from the cell membrane.  Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Associates with the inner plasma membrane through its N-terminal domain.
Protein: VIT1_SOLIN
Sequence: MWYLAFLLIIGAYAADHAWETGNEYHYLIESRTLTVLDKLSQQFSGIVIKGGLTIQVKSPDTLQAVVSKTQYAPVHKTLENWNDEIADLKFDELSMSGKSFEIKLKHGVIRDVLIDQDVLTWEVNLIKSIVSQLQVDLQGENVIASSDNQIPDDSQPFGVYKAMEDSVGGKCEVLYSITPVPENFDSIPFPNLRKDGLNFFVTKTKNYNKCEQQMAYHSGITDKMNWKLGSNDGVLSRSSTSSIIISGNVKHFTIQSSLTTSEIFVRSKLHDTYSSAVYDSVKLTLDRMNQISNPMSASNNLVSTGNLVYIYNNPFSNQRKLRQPSVSLNSMEARSSENSNEENRSDDDRSNFLSNSGEEREYLQSKPTLNEAPESPLLPYFIGYKGESIQKSEDITSVAARFIAQIAWNLETSPVNAFNFSPSTEYIEPCIILIRLIRTMNVEQIAELENKLSDPIYHLQGNKLPTEYKKSYDKTTWDIFFNAVVSAGTGPALISIKNMIKNGQLKDTQAAMIISKIPKTALTPTSEYVNKFFELITDEQVTKQRFLNTSALLAFAELVRYTQSNRSIHYPVHSFGHMVSKQDNALLETYIPYMANQLTEAIKDGDSRRIQTYIMALGNFGHPKVLSVFEPYLEGTLPASTFQRLMMVVSLNRLSENFPRLARSVAFKIYMNIMEAYELRCAAVYVVMKTNPPLVMLQRMAEFTNQDQDRHVNSVIKTNIDALANLEQPEFQDLAAKARIARELLNPHIDTESYSQGFLFKKIIPSLNMAEITILQIIGSQDTTVPKSSYLNIYQSYGGFNLPPSRMSYEISSFRALLDMWYEMPWMIENETQKKLIIEETIEKLGIKGEDPVQFEGNIFVNTLYSSQFSPLDNNTIEETINAFKRIISSWQRSSKNFTSENINYLHYYDMTVAFPTESGLPFIYTLTVPKLLRINIGGGHKGSKTEHFKELTAAGYIMVHEKVQSRIGFVTPFEHRHYVAGIDTNTRLVTPLGLSISVNTTEENKKFKLTLQPSKYIRYGTGHSTVHFSVVPYTARNNILDLEHDFSKQDNDTLPVHTKEPHEIHFYISNWMFVAKSDLIDSKASEKQGMEAIKETVNLFCNSRGAYYRRFDGLMYFGEVRIRASYDFAKLDSDSSEATIPTIVNKEPDSEERKKQFLKEVGKNMNSAYGYVFDMSIDQGFDVQVFTLAYSYSQIDHKSQALFYWNVQSVDDPKIYAELGAIGYVKSKSISLNPEKALEQIPNDEFKAEIRLGNNFNEEMIKLEGNWTRTDDVKDMAMKSEIVKKCRQDMKQGNILLPACQKANKLINQKDLLMMSIDTTSDILYASANRGILWIQSLISENYVETMNLRSSSKNTIDMEIKMLPDNDDAKISLRTSQADVSFSLKDIIGNDSNVSMKDTFKEQLDDESVCVLDKTHAVTFDGKVYPLKLGKCWHVMMTIYPKRDPNNFEKTLSIPSDMRAIVMAQEMDDGSKQIKMILGDQEVHLQKSGDCLEASVDGETANFSDHKSHQEKDFEIYGSNETITVFSPTYEITVEYDGEHILLMISDNYLNAVRGLCGNYDTQPNNDFIIPENCILTKAEEFAATYAMTQESCQGPAPENKRKAEQSTCMSRSYRPSDVISDREAGRSSTKNRGWGYH
What is the function of this protein?
Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.
What are the official names of this protein?
Vitellogenin-1, Vitellogenin, VG.
What are the subcellular locations of this protein?
Secreted.
Protein: AROK_XANCP
Sequence: MNPAPNLVMIGPMGAGKSCIGRRLAERFGLDFVDVDQAIVEQVGSSIPAIFEQHGEARFRQHEAEALHGLLAQSNKLVSTGGGAILDAGNRQRIRERGFVVYLHVSVPAQLTRLARDRNRPLLQRPDREQVLHGMAALRTPLYQEVADLTLETDHLSPAEATAQLVLRLAAQWRMSSTPA
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYQ_SALNS
Sequence: MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYQGQCNLRFDDTNPVKEDIEYVDSIKNDVEWLGFHWSGDIRYSSDYFDQLHAYAVELINKGLAYVDELTPEQIREYRGTLTAPGKNSPFRDRSVEENLALFEKMRTGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYPQGESEMVTMPNHPNKPEMGSREVPFSGEIWIDRADFREEANKQYKRLVMGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPIEIRLYDRLFSVPNPGAAEDFLSVINPESLVIKRGYGEPSLKAAVAGKAFQFEREGYFCLDSRYATADKLVFNRTVGLRDTWAKAGE
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLYX_CUPPJ
Sequence: MDDRLNELEIKLAFQEDLLETLNLTVARQQQQLDLLQEQFRALYQQVTSAPSTAAESNPQHEIPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: ENVR_ECO57
Sequence: MAKRTKAEALKTRQELIETAIAQFAQHGVSKTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQPSLRELIQEHLTAGLEHDPFQQLREKLIVGLQYIAKIPRQQALLKILYHKCEFNDEMLAEGVIREKMGFNPQTLREVLQACQQQGCVANNLDLDVVMIIIDGAFSGIVQNWLMNMAGYDLYKQAPALVDNVLRMFMPDENITKLIHQTNELSVM
What is the function of this protein?
Potential regulator protein for the acrEF/envCD genes.
What are the official names of this protein?
Probable acrEF/envCD operon repressor.
Protein: PANC_YERPP
Sequence: MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPLQFERPDDLAHYPRTLQEDCEKLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEGASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIRKMVADMGYDINIVGVPTVRAKDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEEAAAQLLRVGFTPDELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_PROMO
Sequence: MKKMGPIILAVVIAIGTFALKMMGVIGFKTPPLVEGPKIMFYVPLPEAMHDFPFAMEMASGVYGFPVTITVISTWFVMLFLIMVFRWSSKNLEVVPERKQAFFETIYGFLDDLYGQLLGNWKKKYFTYIGTLFLFLLISNIVSFFPIPGFSSENGVFSIAPALRTPTADLNTTVGLALLTTYSFIAASFRTSGFFGFFKGLFEPMPLMFPINLAGEFAKPTNISIRLFGNMFAGMVILGLLYKAAPVLIPAPLHLYFDLFSGVVQSFVFIMLTMVYIQGSIGDAEYLED
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, sodium ion specific, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MD2L2_BOVIN
Sequence: MTTLTRQDLNFGQVVADVLCEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLPISSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKSS
What is the function of this protein?
Adapter protein able to interact with different proteins and involved in different biological processes.  Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis.  Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions.  Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs).  During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection.  Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.  May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1.  Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle.  Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
What are the official names of this protein?
Mitotic spindle assembly checkpoint protein MAD2B, Mitotic arrest deficient 2-like protein 2, MAD2-like protein 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.
Protein: EFNA2_MOUSE
Sequence: MAPAQRPLLPLLLLLLPLRARNEDPARANADRYAVYWNRSNPRFQVSAVGDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMERYILYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNLVDRPCLRLKVYVRPTNETLYEAPEPIFTSNSSCSGLGGCHLFLTTVPVLWSLLGS
What is the function of this protein?
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.  Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
What are the official names of this protein?
Ephrin-A2, CEK7-ligand, CEK7-L, ELF-1, EPH-related receptor tyrosine kinase ligand 6, LERK-6.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: RL18_OLEA2
Sequence: MKLTKNESRMRRKIRIRKKVSGNGARPRLVVYRSNLHIYAQLVDDQTGTTLAATSTLALGKQNGNALRLTVDNASLVGKEIAKLAKEKNIERVVFDRNGYIYHGRIKAVADGAREAGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RLMKL_HAEDU
Sequence: MSNQITYFATAARGFEEMLKIELEQICGADGKVVQGGVHFTTNQKGAYQALLHSRLASRILLPLVSTKIFSDLDLYATIIAINWADIFDPRDTFYVDFNGTNREIRNTQFGAMRVKDGIVDYFERKRFARPIVDKDRPDIRIHVYLDREKLIVSLDLSGEALHMRGYREDTGKAPLRETLAAIIVLRSGWQKGTPLVDPMCGSGTLLIEAAQMQAGIVPQLQRKYWGFNAWKGHQQAIWQQVLEEAHSQKNTQIDPLFYGFDLDHRVLAKAKQNAQNAGVAHLIHWQQADIAALKNPCLDQKGTLVSNPPYGERLGTTPALIALYSVFGQRLKQQFAGWNVSIFSGEPSLLNCLRLRSTRQFKAKNGPLDCLQKNYQIAEYAIHNQHISESSVAQNTQVAPDFANRLTKNIKKIEKWAKQQQLDAYRLYDADLPEYNFAVDRYSDHIVIQEYAAPKSIEQNKARQRLLDAVTATLHVTGIETNKLVLKVRQKQKGTNQYEKLANKGEYFYVNEYGAKLWVNLTDYLDTGIFLDHRLTRKMVGQMAKGKTFLNLFAYTGSATIHAALHGAKATTSVDMSNTYLNWAEQNLELNGLKSRNHRLFQADCLQWLAECRERFELIFVDPPTFSNSKRMEDSWDVQRDHIKLMTQLKRILTSDGMIVFSNNKRGFKMDFNGLTALGLVAENISYKTLPLDFERDPHIHNCWIIRHIEN
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAH43_RANDH
Sequence: GLWQLIKDKFKDAATGFVTGIQS
What is the function of this protein?
Has no antimicrobial activity.
What are the official names of this protein?
Dahlein-4.3.
What are the subcellular locations of this protein?
Secreted.
Protein: GPC6A_RAT
Sequence: MALSFVFITCFMILLDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRQPQIQKCVGFEISVFLQTLAMIHSIEMINNSSLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVIFQCDYSSYVPRVKAIIGAGYSEISMAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWVGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFNKAIERKISKIWIASDNWSTAAKIITIPNVKKLGKVVGFTFRRGNMSSFHSFLQTLHMYPSDNNKPLHEFAMLFSACKHIKDGDLSQCISNYSQATWTYDTTKTIETHLFKRNDFLWHYTEPGLIHSIQLAVLALGHAIRDLCQDRDCQKPNAFQPWELLAVLKNVTFTDGKNSFHFDAHGDLNTGYEVVLWKETNGLMTVTKMAEYDLQHDVFITTNQETKHEFRKLKQILSKCSKECIPGQMKKATGSQHSCCYECVNCPENHYSNETDMDHCLVCNNETHWAPVRSTMCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAVGIIFTRNLKTPVVKSSGGLVVCYVMLACHALNFASTGFFIGEPQDFTCKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPTLKTFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPTVEENTSLPRVIILECEEGSALAFGTMLGYIAVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYATTFGKYLPAVEIIVILISNYGILCCTFFPKCYIILCKQKTNTKSVFLQMVYNYSAHSVDSLALSHVSLDSASHSTATTNPRPGNKTAACQNYKHLPVQVLAHTGMEKTMHASKTLHQKRSSSI
What is the function of this protein?
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids.  The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+).  Activated by extracellular calcium and osteocalcin.  Seems to act through a G(q)/G(11) and G(i)-coupled pathway.  Mediates the non-genomic effects of androgens in multiple tissue.  May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (By similarity).
What are the official names of this protein?
G-protein coupled receptor family C group 6 member A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
Protein: SPC25_YARLI
Sequence: MTTLPTLPPLPEDIVTGMEELKIVMSAALERQRSQLVQSRQDVNRVLKELEEESKGVSLEIESHMARQHDLRLQISELDKQIEDSKGTIVEYSRRRSELESKVEAAQRACDEGRQRLEEQQSLRRRQVQHVMEQSVRNVPELMYMEDLLGMKIEAVQDDQLRFVFVKLDPNDYAREFAFVLDMADVNYRVEQLEPTLDLSVVDRVVGKLNSSRNFPQFLKEIRQAFKDAIME
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Probable kinetochore protein SPC25.
What is the protein family that this protein belongs to?
Belongs to the SPC25 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.