PharMolix/UniProtQA huggingface dataset:
Protein: MERTK_HUMAN
Sequence: MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6.  Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis).  Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1.  MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed:32640697).  Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis.  Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
What are the official names of this protein?
Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: FTSH_LACPJ
Sequence: MNNRRNGLFRNSLFYILMFLSLMGIIYFFFGGNSGSQTQNIRYSEFVKQLDKNNVKNVSIQPSGGVYKVTGSYRKARTTSSANALGIKSASTKTTSFSTTMLENNSTVDQVSKLAAKHDVKVTAKAEESSGIWVTLLMYIAPVILMLFLFYMMMGQAGQGGGNNRVMNFGKTKAKPADSKQNKVRFSDVAGEEEEKQELVEVVEFLKDPRKFVSLGARIPSGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKNAPSIIFIDEIDAVGRQRGNGMGGGHDEREQTLNQLLVEMDGFTGNEGVIVMAATNRSDVLDPALLRPGRFDRKILVGRPDVKGREAILKVHAKNKPLAADVDLKEIAKQTPGFVGADLENLLNEAALLAARRNKKQVDAADLDEAEDRVIAGPAKHDRVVNKHERETVAYHEAGHTIVGLVLNDARVVHKVTIVPRGRAGGYAIMLPREDQMLMSKRDAKEQMAGLMGGRAAEEIIFGAQSSGASNDFEQATQIARAMVTQYGMSEKLGPVELENANQQAAYQQGMGASAFSQHTAQLIDDEVRRLSQEAHQTATDIIESHREQHKLIAEALLKYETLDEKQILSLFKTGKMPEKDSNEFPSEKAATFEESKRELERREAEKHAQNQSADDKQADSADTTTNVSVAEPSFPSESDASSEVSADSSVNSTANSATESATDSDVATSATGLPNAESATPSSQDDTNSQA
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: YVPB_BACSU
Sequence: MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSDTDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLANQVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSISAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYLNDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK
What are the official names of this protein?
Uncharacterized protein YvpB.
Protein: SPOPA_XENLA
Sequence: MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIKDVEPDVFKEMMCFIYTGKASNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVMETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS
What is the function of this protein?
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
What are the official names of this protein?
Speckle-type POZ protein A.
What is the protein family that this protein belongs to?
Belongs to the Tdpoz family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: RNFB_ALKEH
Sequence: MLTPILALTALALIAGALLGFAAVRFRVEGNPIADQVDAVLPQTQCGQCGFGGCRPYAEAIAAGEAEINRCPPGGQDTVQTLADLLGVEPLPLDEERGEAPHTPQVAWVDEAVCIGCTRCIQACPVDAILGAAKQMHTVLKGECTGCGLCVDPCPVDCIHMVPVDLDLAEWHWPLPQNDTARREVA
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: CLH_SCHPO
Sequence: MAQQLPIRFSEVLQLASVGIQPSSFGFANVTLESDKYVCVRDNPNGVNQVVIVDLEDPSNVLRRPISADSVILHPKKKIIALKAQRQLQVFDLEAKAKINSYVMNQDVVYWTWISDSVIGMVTDTSVFHWTVSGSDPVKMFDRHSSLNGTQIISYKSNYNEEWFTLIGISSRDNRIAGNLQLYSKKRKVSQPLESHASAFAVIQPEGVDHEVQVLALASRLPTGSKLSIVEVDRNPNNPAFATKTVDLFFPPEAVNDFPIAIEIGSTYNVAYVVTKYGFIHVYDLETAKCIYMNRVSGESIFVTTAHKSVNGLMAINRKGQVLSVSINPETIIPYILSNLNDPGLAVRMASHANLPGADNLYMQQFQQLMAQGNYSEAAKVAASSPRGILRTSQVIDQFKLIQAAPGQIAPILQYFGTLLDKGPLNEHETIELARPVLAQNRIQLLEKWYGENKLACTEALGDLVKPYNTPFALKIYETANVPNKVVMCLSELGDFGKLATYTSQQNITPDYVSLLQNLVRVNPDQAAEFATQMFNSNPSINLEKIVDIFMSQNLVQQATAFLLDALKDDNPEHSHLQTRLLEINLINAPQVADAILGNQMFTHFDRAVIASLCERAGLVQRALELYDKPADIKRVIVHSNLLNPEWLMNYFSRFSPDEVYDYLREMLRSNLRQNLQIVVQIATRYSDLVGAQRIIEMFEKFKTFEGLYYYLGSIVNITEDPEVVYKYIQAACLMNQFTEVERICRDNNVYNPEKVKNLLKEAKLADQLPLILVCDRYDFVNDLVFYLFRNNMFQFIEIYVQRINPSKTPQVVGALLDIDCDEELVQNLLMSVVGQVPVDELVEEVERRNRLKLLLPYLESLLQSGSQDRAIYDALAKIYIDSNNNPEVFLKENNFYDTLTVGKYCEKRDPYLAFIAYEKGGNDTEIINLCNENSMFKQLARYLLKRSDSNLWSEVLQDSAYRRPLLDQVIATAVPESSDPEAVSIVVKALMEVDLPSQLIELLEKIVLQPSSFSENANLQNLLFLTAIKADKSRVMEYIDKLDKYDVDEIAEIAIENGLYEEAFRIYKIHNKHEQAMKVLVEDIVSLDRAQDYAETVEQPEVWSRLAKAQLDGIRIPDAIESYLKADDPSNYSEVIELASRAGKYEELIKYLLMARSKMHEPDVDSALLIAYAKTNQLTEMETFLIGSNVADVKAVGDECFESKNYEAAKLMYSSISNWSMLATTLVYLGEYQGAVDCARKANSIKVWKQVGTACIDKREFRLAQICGLNLIVHAEELPGLIRLYEERGYFEEVISLMEAGLGLERAHMAFYTELAILYAKYKPERMMEHLKLFWGRLNMAKVIRACDQMHLWNEAVFLYVHDQSYDNAAAVMMEQPEAFDHQSFKDIIVHVANLELYYRALNFYLEQHPMLLTDLLAALTPRIDHPRVIRIFEKSENTPLILNFMVAIQHLNIQAVNHAYNDLLIEMEDYQSLQDSIENYDHFDAIALARRLEKHSLLEFRRIAAYIYRKNKRWTQSIELSKQDRFYKDAIITARDSDQTTIAEDLMKYFVEIGNYECFAAILYTCYHLLRNDLVMEISWRKGLQDYAYPYFINFQCEMFSKVLNLEKDLKDRQAVKSEEESASTIGAGILGNTLMLTQGPMANNNDQFDSFQQASPMPRLGNF
What is the function of this protein?
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
What are the official names of this protein?
Probable clathrin heavy chain.
What is the protein family that this protein belongs to?
Belongs to the clathrin heavy chain family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Protein: ARI8_ARATH
Sequence: MEADDDFYSGTENYSDYADSDEDDADGEYEFVDDAADDSDDLIFRRRQQNYSVLSEADICKLQEDDISRISTVLSISRNSSAILLRHYNWCVSRVHDEWFADEEKVRDAVGLLEKPVVDFPTDGELDCGICFETFLSDKLHAAACGHPFCDSCWEGYITTAINDGPGCLTLRCPDPSCRAAVGQDMINLLAPDKDKQKYTSYFVRSYVEDNRKTKWCPAPGCDYAVNFVVGSGNYDVNCRCCYSFCWNCAEEAHRPVDCDTVSKWVLKNSAESENMNWILANSKPCPKCKRPIEKNQGCMHITCTPPCKFEFCWLCLGAWTEHGEKTGGFYACNRYEAAKQDGIYDETEKRREMAKNSLERYTHYYERWATNQSSRQKALLDLKKMQTDDIEKLSDIQCQPESQLKFIIEAWLQIVECRRVLKWTYAYGFYIPDQEHGKRVFFEYLQGEAESGLERLHQCAEKELLPYLDAKGPSEDFNEFRTKLAGLTSVTKNYFENLVRALENGLSDVNSHDAYDRTSSSKSLGGKTKGSSSKASSSDSSHWPCEYCTYVNPRSTTICQMCEHGR
What is the function of this protein?
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase ARI8, ARIADNE-like protein ARI8, Protein ariadne homolog 8, RING-type E3 ubiquitin transferase ARI8.
What is the protein family that this protein belongs to?
Belongs to the RBR family. Ariadne subfamily.
Protein: Y1414_SHESM
Sequence: MNKDDDKEGMAMFSALIEGIKPIAQDKRHFRTPLKTKQEIELKEQQLHANSYFSDTYQPLLPVQGPMRWLDEGVDSLELKRLRRGDYQPDLLLDLHGYRQSEAKLELAALIQACVKQQSQCCCVMHGYGTGILKQQVPMWLVQHPMVKAFHQAPKEWGGDAALLVLIDIGDQPHRR
What are the official names of this protein?
UPF0115 protein Shewmr4_1414.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: TPIS_BUCAP
Sequence: MKKKIIAANWKLNGSIKTISYFLTFLKSQISSFLKNNIIIIAPPTVFLERVYKDINSINIHLAAQNIDVNLTGAFTGENSALMMKDIGVKYIIIGHSERRLLHNENNEIIAKKFCLVKNLNLVPILCIGETEAEKKSNKTEKILKEQLNSIFNSFGEKAFRNAVIAYEPIWSIGTGVSADPKNVQLIHKFIKNYIKKYDIVSAENLIVQYGGSVTSLNAGNFLKQPDIDGLLIGSASLKHEEFLKIIKISDSFL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_BURP6
Sequence: MAKASNTAAQRVRKKVKKNVAEGVVHVHASFNNTIITITDRQGNALAWATSGGQGFKGSRKSTPFAAQVAAESAGRVAMEYGVKNLEVRIKGPGPGRESAVRALHGLGIKITAISDVTPIPHNGCRPPKRRRI
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: FTMT_HUMAN
Sequence: MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIAPRRPLAAAASSRDPTGPAAGPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSREETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAMECALLLEKNVNQSLLELHALASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGLAEYLFDTHTLGNENKQN
What is the function of this protein?
Catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form (PubMed:11323407, PubMed:15201052).  Important for iron homeostasis (PubMed:11323407, PubMed:15201052).  Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:11323407, PubMed:15201052).
What are the official names of this protein?
Ferritin, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ferritin family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CCKAR_RABIT
Sequence: MDAVASLLGNASGIPPPCELGLDNETLFCLDQPPPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAISDLMLCLFCMPFNLIPNLLKDFIFGSALCKTTTYLMGTSVSVSTLNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFAIMTPYPIYSNLVPFTKTNNQTANMCRFLLPSDVMQQAWHTFLLLILFLIPGIVMMVAYGMISLELYQGIKFDASQKKSAKERKASTGSGRFEDNDGCYLQRSKPTRQLELQQLSGGGGGRVSRIRSSSSAATLMAKKRVIRMLMVIVVLFFLCWMPIFSANAWRAYDTVSAERRLSGTPISFILLLSYTSSCVNPIIYCFMNRRFRLGFMATFPCCPNPGPPGPRAEAGEEEEGRTTRASLSRYSYSHMSASAPPS
What is the function of this protein?
Receptor for cholecystokinin.  Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach.  Has a 1000-fold higher affinity for CCK rather than for gastrin.  It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system.  This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
What are the official names of this protein?
Cholecystokinin receptor type A, CCK-A receptor, CCK-AR, Cholecystokinin-1 receptor, CCK1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS11_PYRCJ
Sequence: MSTAETPQQPQQQQKLRWGIAWIYSSSNNTIITITDLTGAETVARVSGGMVVRADKDKPSPWAAMQAAYKAAQLALARGINAVHIKVRGPGGYGMKVPGPGASAAIRALARSGLVIGRIEDVTPIPHDTIRPPSGRKGRRV
What is the function of this protein?
Located on the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ISPG_VIBCH
Sequence: MQHESPIKRRPSTRIYVGDVPIGDGAPIAVQSMTNTRTTDVAATVAQIKSLEKVGADIVRVSVPTMEAAEAFKLIKQQVSVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEARIRSVVDCARDKGIPIRIGVNGGSLEKDLQLKYGEPTPEALVESAMRHVDILDRLNFDQFKVSVKASDVFLAVDSYRLLAKKIDQPLHLGITEAGGARAGSVKSAVGLGMLLAEGIGDTLRISLAADPVEEIKVGFDILKSLRIRSRGINFIACPSCSRQEFDVIGTVNALEQRLEDVLTPMDVSIIGCVVNGPGEAEVSHLGLAGSNKKSAFYEDGVRQKERFDNDDLVAQLEAKIRAKAARLDEKNRIDIKHVEQD
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: PUB47_ARATH
Sequence: MADSTADESTNADTLWRELHKVLPEIWYDGGGKDHCEIDEAIRILTCLRKIESKNPESDISPVEVPKEFICTLSNKIMIEPMLIASGQTFEKSYILEWLKHERTCPRTKQVLYHRFMIPNHLINEVIKEWCLIHNFDRPKTSDEVIDLFTGDLESLLQRISSPSSVEDQTEAAKELALKAKRFSSVCVYFVAKIPDSITRLLTPLSISEDSNPEFLENIVTALHIFSTSEKNKTLVAENPLVLPLLAKYMKQGTVLTRIHSAATVNSLSYTDSNKIIIGNSEVLKALIHVIEEGDSLATSEAFSALSNLCPVKEISEKAVSEGLIRAAIKKIKAGSNVSMLLSLLAFVSTQNHQTTEEMDNLGLIYDLFSILRNSNSLVNDENAVVIVYNICKSYKALQNVVLREEKRDVVLEEENKHGTFTRLENQEAGRATSLAKRILEWILR
What is the function of this protein?
Functions as an E3 ubiquitin ligase.
What are the official names of this protein?
Putative U-box domain-containing protein 47, Plant U-box protein 47, RING-type E3 ubiquitin transferase PUB47.
Protein: TOP2_TRYCR
Sequence: MAEASKYKKLTPIDHVLIRPEMYVGSVDTSSSSMFVFDHEKGRMVWESLKVNHGLLKIVDEILLNASDNIANKGGRMTYIRVHITEAGEITIENDGAGIPIVRSKEHKLYIPEMVFGHLLTSSNYDDTSQNAVAGRHGYGAKLTNILSHRFSVCCRTKGKEFHMSWHDHMRRATAPRVSNVDPKEKNLTRVKFLPDYERFGLDANKISHDMKRVLHKRIMDLAAMFPSIEISLNGVPFAFKSFADYAMLYSSPSSSGEMPPAPFVYESRNGAIAFIPSLTAGTRRIFGVVNGVVTHNGGTHCNAAQEVLQSSLESVEKALKKDNKVIDTNRVLRHFMILVFLVQVQPKFDSQNKARLVSVPTMPRVPRQELMDFLLRMPFLEAHVNTVTGQLADELNKEMGAGRRMSSKSLISSITKLVDATTTRRDPRFVRTLIVTEGDSAKALAQNSLSSDQKRYTGVFPLRGKLLNVRNKNLKRLKNCKELQELFCALGLELGKIYKDAEELRYQRLLVMTDQDADGSHIKGLVINAFEALWPSLLNRNPGFISIFSTPIVKVRLRDKSTHSFFSLKEFHKWQKTHGNVSYTAKYYKALGTSTTAEGKEYFKDMDKHTMRLVVERNDHKLLDSVFDSQEVEWRKDWMTKANAYTGEVDIDRSKKTLTVPDFVHKEMVHFALAGNARALAHAVDGLKPSQRKILWAIMRRSGNESAKVAQLSGYISEVSAFHHGEMSLQETIIKMAQNFTGGNNINLLIPEGQFGSRQQLGNDHAAARYIFTKLSSLARILFPSEDEPLLDYVTEEGQQVEPNHYVPILPLLLCNGSVGIGFGFASNIPPFHPLDVSAAVRSMINGEAAKVVVRRLVPWAVGYQGEVRRGPEGEFIAAGSYQYYVDGRVHVTEIPWTLSIEAFRDHISVLASKDVVQRIADYSGANHVDIDLELTNGAMTTYAECESELSLTQRIYINGTVFSPTGVLTPLEGDLAPVLQWHYDRRLDLYKKRRQRNLGLLEAELAREKSTLKFVTHFREGKIDIVNATDDSLAKTCSKLGMVRVDDSYDYVLRKPITFYTKTSLENLNRKISETEKRIDKLKKTAPVQMWLDELDRFDRAFEEHENTAVATILKERRVNPPTGDVSRNLQQPRLELEEVKVSSSGGKSVPMRVRVRKYVPPPPSKRPHVGQSVGGGGGGGSVRSSAAAVVAHVKAEKKAARARSMQKMLLDVVARQVARVLPRLPWFLF
What is the function of this protein?
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands.  Topoisomerase II makes double-strand breaks.
What are the official names of this protein?
DNA topoisomerase 2, DNA topoisomerase II.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARP4_NEUCR
Sequence: MSHQQPLSSSVQPTDIYGGDEVSALVLDPGYCNTRAGYAGEEMPKQVLPSFYGHINGRDVFGDEYIVPKPGFEVRNYMNRDSVVEDWDAATRMWEHVLVKRLQPERSTPPSKKGINISDDGDVPMEDDGNNNEDATDALEKPLAENPLLMTEAPWNSPKAREKAIEISMETWGVPAFWLSKTPVLAAFAAGKATALVIDVGGANTSVTAIHDGMVLKRSIQRSPVGGVWLSSQICKMWDGSEPKVDVVPRFMVESKKPVEAGAPAEANLRKFNFDIHPSFRAYEEERVLTEFKESVVEVWRGPQRFTTPGNEDAVRTQPGRVFEMPDGSNQMWREQRFKVSEGMWDETAAYNSTDEEGRVTKAQTIPALIKAALEGVDVDLRPNILGNVVVTGSTSLLNGFNDRLNHELAQMYPGVKIKIHAAGLTTERRFGAWIGGSILASLGTFHQMWISRKEYDENGAGIVEKRCK
What is the function of this protein?
Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair.  Is required for NuA4 complex integrity.  Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A. Z leading to transcriptional regulation of selected genes by chromatin remodeling.  Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
What are the official names of this protein?
Actin-related protein 4, Actin-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: NFUA_BAUCH
Sequence: MIIITDTAQKYLTTLLAKQKSGTQIRVLVLNPGTPIAECSLSYCPIDTVTKKDIKLEFDQFCVYVDQLSTSYLEDALIDCVLDELGTQLIIQAPHLIEKIDSNTPLLERVNQIILSCINPQLANHGGKVTLITITEDMFAIIQFSGGCNGCSMVSYTLKEHIEKKLLQLFPELKGVKDLTQHNHSQYSFY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: HOA_KLEP3
Sequence: MNGKKLYISDVTLRDGMHAIRHQYSLAQVQQIAGALDKAGVDSIEVAHGDGLQGSSFNYGFGAHSDIAWIEAAAEAVSQAKIATLLLPGIGTLHDLKAAYQAGARVVRVATHCSEADVAAQHIAFARELGMDTVGFLMMSHMISPQALAQQALKMESYGATCIYVVDSGGAMNMNDIRDRFRALKAVLKPETATGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMNAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHSEAAAERYGLSAVDILVELGKRRMVGGQEDMIVDVALDLLNRNK
What is the function of this protein?
Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde.  Is involved in the meta-cleavage pathway for the degradation of aromatic compounds.
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase, HOA, 4-hydroxy-2-keto-pentanoic acid aldolase, 4-hydroxy-2-oxopentanoate aldolase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: ISCS_BUCAT
Sequence: MKTPIYLDYAATTPVEFEVAKKMMNYLTIDGVFGNSASRSHKFGWKAEEVVDIARNQISELIGADSREIVFTSGATESNNLAIKGIASFHQNKGKHIVTSKTEHKSVLDTCRYLENKGFTVTYLTPKNNGIIDLNNLKKNIKKDTILVSIMHVNNEIGIIQDINSISQICRNHGVFFHVDATQSVGKIPIDLKKIPIDLMSFSAHKIYGPKGIGGLYVRRKPRVRLLSLIHGGGHERGMRSGTLPVHQIVGMGESFVLAKRKIHDDFIHLTKLKNILWNGIKNIEEVYLNSDLQQGAPHILNVSFNYVEGESLIMALKDLAISSGSACTSASLEPSYVLKSLGIRDELAHSSIRFSIGRFTTEKEIIHAIKLVHKSIHRLRELSPLWEMFKSGVDLNSIEWDHV
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_LATSS
Sequence: MAEHRFEDFNGLVMYRKNYKEKDMLVKILTDRFGKKMFYLRGANKPKFRLSAAILPFTQAEYGGDIRDDGLSFLNNVKSATQFQTISQDLFLNAYATYILNLIDVGFPDSEPLGIWYDKVEQALNLIDEGFDAAMITHIIEIQLLQVFGVQPQLQGCAVCGRTDLAFDYSESYGGLLCQRHWHLDPNRFHSSQRAIYYLRLFSVIDLFKIQSVNVKEATQVELKMIIDRLYQDTVGLSLKSKQFIDKMYSFDSQLPQLKKVPSEIDSTPKDD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: P14_ASFM2
Sequence: MADFNSPIQYLKEDSRDRTSIGSLEYDENADTMIPSFAAGLEEFEPIPDYDPTRSTSLYSQLTHNMERIAEEDDINFQHDTREFTSLVPEETDNKPEDDEESGAKPKKKKHLFPKLSSHKSK
What is the function of this protein?
Structural protein required for transport of intracellular particles from the assembly sites to the plasma membrane (By similarity).  Binds to both ssDNA and dsDNA (By similarity).  Suppressed the activation of the cGAS/STING pathway by interfering with the recruitment of IRF3 to TBK1, which in turn suppresses IRF3 phosphorylation, decreasing interferon production (By similarity).
What are the official names of this protein?
Structural protein p14.5.
What is the protein family that this protein belongs to?
Belongs to the asfivirus structural protein p14.5 family.
What are the subcellular locations of this protein?
Virion. Note=Localizes at the surface of the intracellular virion.
Protein: THII_STRP6
Sequence: MDYSEIMVRHGELSTKGKNRMRFINKLKNNIQDVLAPFPAITVRSDRDRTHVYLNGTDYQPVVEALKLVFGVQALSPVYKLEKSVPLLVTAVQDIMTSLYRDGLTFKIATKRSDHAFELDSRELNSLLGGAVFEVLPNIQAQMKHPDVTLKVEIRDEAAYISYEEIKGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGLDIEVVHFASPPYTSPGALAKAQDLTRRLTRFGGNIQFIEVPFTEIQEEIKNKAPEAYLMTLTRRFMMRITDAIREQRKGLVIVNGESLGQVASQTLESMQAINAVTSTPIIRPVVTMDKLEIIEMAQAIDTFDISIQPFEDCCTIFAPDRPKTNPKLGNAEKYEERFDIDGLVQRAVSGIVVTEITPEIVNDEVENLIDALL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.