PharMolix/UniProtQA huggingface dataset:
Protein: NU4LM_MYTED
Sequence: MVWMKFLGVLLMSMGCFVIFRMNKHLLCLFVGLEMMSLGLLFVTHVFLMNQFWLILLILCLAVCEASICLALLVMVMRLCGDDLMSSLLSDGS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: OBG_FRAT1
Sequence: MRFVDEVVIKLQAGKGGNGCVSFRREKYVPRGGPDGGDGGNGGSIYLKADENVNTLIDYRYKREYYAENGRPGEGRNCYGKAGEDLYLVVPVGTSVFDIDTNKKIGEVLQHGQTFKLVSGGKRGIGNTHFKSSTNQAPRKFTLGEEGEYKEVRLELNLLADVALLGLPNAGKSTLIRSVSEATPKVADYPFTTMYPHLGVVKVGVDSFVMADIPGVIEGAAEGAGLGLRFLKHLTRARCVLHVVDICPFNESDPVENYFAVEKELEKYSQELFDKPRFLVINKIDLLADKVEQKCQEFVEQIGYQGNYYTISAAMKKGTDELAKKLNEFLQKQE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_ALKCK
Sequence: MKVIFTEDVKGKGKKGELKDVSEGYARNYLIPKNLAVAATSGNIKDLEAQEKSKQKKAEAELQKAKAMKEELEALKIEIPAKAGEGGRLFGAVSTKQIAEALGKQGKKVDKRKIQLDEPIRSLGYTKVPIKIHPEVVATATVHVVEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: LYTR_STAA8
Sequence: MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDENGIELGAKIQKMKEPPAIIFATAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKAKDDNNASAIANDMSANFDQSLPVEIDDKIHMLKQQNIIGIGTHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFKASIGLL
What is the function of this protein?
Member of the two-component regulatory system LytR/LytS that regulates genes involved in autolysis, programmed cell death, biofilm formation and cell wall metabolism (PubMed:19502411).  Participates also in sensing and responding to host defense cationic antimicrobial peptides (HDPs) (PubMed:23733465).  Upon phosphorylation by LytS, functions as a transcription regulator by direct binding to promoter regions of target genes including lrgA and lrgB, to positively regulate their expression (PubMed:8824633, PubMed:25491472).
What are the official names of this protein?
Transcriptional regulatory protein LytR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_ANAD2
Sequence: MLDLSLPSGLRDLLPDHSAHLAELSSKLHDVFSRFGYRRVFLPTLERLDVVERGLSPAALADVMKFVEPGSGEVVAIRPDITPQIARLYAARPDALPSPARLCYDGPVLRAREARAGRPREVYQAGVELLGAGGASADAEALVLLARSLERVGLKAPRVEVGHARFAEAVMEAARLPERLRSAAWEALSRKDRAALAAAAAKGRGSAEAREAVPQLAGLFGDGALDRARAIARAVPEAAASLAETEAALRIARRRGVREVAVDLGEARGLGYYTGITFAGYAPGAGAAVARGGRYDGLLARFGRPGPAIGFAVDLEFATQALERVNGRGRGVRPRRASARGGRARARPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_TRIEI
Sequence: MLKSTDLKNESEMSRVKVLSEALPYIQKFTGRKIVVKYGGAAMRDSNVKDQVMRDIVLLSCVGIRPIVVHGGGPEINSWLGKLGIEPQFKDGLRVTDASTMEVVEMVLVGKVNKEIVSLINQAGGCAVGLCGKDASLIQARPEGIEGIGFVGEVSNVKIDILQSLVDNGYIPVVSSVATDEQGQAYNLNADTVAGEIAAAMEAEKLILLTDTAGILEDYHNPDSLIVKLDIQEARELIEKGIVSGGMIPKVNCCVRSLAQGVRAAHILDGRVPHVLLQEILTDTGVGSMIVA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_HELAH
Sequence: MEITLFDPIDAHLHVREGVLLKAVLKYSSEPFSAAVIMPNLSKPLIDTQITLEYEGEILKNSSNFKPLMSLYFNDGLTLEELQHAKHQGIKFLKLYPKGMTTNAQNGTSDLLGEKTLEILEDAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFAHSFPKLKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTQKDQERLLSLALKAHPKISFGSDSAPHVISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKKIYTLDNLPSKKVRLSKKPFIVPTHTLCLNEKIAILREGETLSWNIQEIA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: HBSAG_HBVE1
Sequence: MGLSWTVPLEWGKNISTTNPLGFFPDHQLDPAFRANTRNPDWDHNPNKDHWTEANKVGVGAFGPGFTPPHGGLLGWSPQAQGMLKTLPADPPPASTNRQSGRQPTPITPPLRDTHPQAMQWNSTTFHQALQDPRVRGLYFPAGGSSSGTVNPVPTTASLISSIFSRIGDPAPNMESITSGFLGPLLVLQAGFFLLTKILTIPQSLDSWWTSLNFLGGAPVCLGQNSQSPTSNHSPTSCPPICPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMTLAQGTSMFPSCCCSKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFAGLSPTVWLSVIWMMWYWGPSLYDILSPFIPLLPIFFCLWVYI
What is the function of this protein?
The middle envelope protein plays an important role in the budding of the virion.  It is involved in the induction of budding in a nucleocapsid independent way.  In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
What are the official names of this protein?
Large envelope protein, L glycoprotein, L-HBsAg, LHB, Large S protein, Large surface protein, Major surface antigen.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus major surface antigen family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: DNAJ_HALHL
Sequence: MAKRDYYEVLGVNKNASDAEIKKAYRRMAQKFHPDRNPGDEESAERFKEVKEAYEVLSDAQKRAAYDQFGHAGVDPSAGGGPRGYGGGAGPGGPDFSDIFSDVFGDIFGSGGGRGGGRSRAFRGADLRYTLELSLEDAVRGTEEQIQVPTHVECDACKGSGSRAGSKPQTCPTCKGHGDVRVQQGFFSIQQTCPRCGGEGTMVTDPCPKCRGRGRVEDRKTLNVRIPAGVDTGDRIRLSGEGEPGERGGPPGDLYVQVAVREHEFFERDGADLHCQVPVDIVTAALGGEVEVPTLDGRVNLRIPPGTQPNQVFRLRGKGVKPVRGNRQGDLLCRIHVETPVNLTKRQRELLEEFQATLQDTGGKHHPHTSSWLDKVKRFIEEWRI
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_BACC4
Sequence: MANIKSAIKRAKLSEERRAHNASIKSDMRSAVKTVEALVTNNDLENAKEAFKTASKKLDKAARKGLIHQNAAARQKSRLAKQVNA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: MUTL_THEYD
Sequence: MNRIKILPETIVGKISAGEVVERPASVVKELIENSIDAGANSISVYIKEFGIAEIKVIDDGEGIPSDDVILAFQRHATSKIKDEKDLQRISSLGFRGEALYSIANVSKLKIITQYKDEDTGTEVYLTGGNLVSQKPVVTKGTTVEIRDLFFNTPVRRKFLKSSYTEKAHIIETVQNYCLAYPEISFSLFIDREEVLNIPQVKTLYDRISQVFGLEFTEKLKFKTISKDNYKIELFLGGEELLRKSKGRQLIFVNRRPVKDFSIVNTIYKAFHINENHPQFFIFINLPPEDVDFNVHPAKKEVRFREPQIIHQLIFRMSEYQVKSSMIAEETNQWKVNADLSSISQISAFYTESIFNKEEIFHFFSIGDAIVVIQRVDGIVFLDFHAAHERVNFEKILNKMSEQIVKLTFPHVINLNPQDYVLIKENLHILNELGIEAEDFGENSIVIRALPEIIKYIDIAGMIENIALTLKEGTSTPDFIEIKRKIAATIACHSSLRANEKINHFEIKALLQELERTSDPEHCPHGRPVRKFISLDEIKKWFLR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: HLDE_SHIDS
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNITSLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRAETGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: Y7697_DICDI
Sequence: MLLKLILILCFLVTLSLSVKVDSADPALFTQGPTIASGGTGNTGANPCYGHDDEDGSKDPAMFTQGPVSSGSGSGSGGYCPHHKNRAQEGGKKDTTKEQPKENNNNKNLGRHSSSGSGSGSGSGCGVTGDTGTGSGRTTAPVNDGVTYKSSNVKETEQYRGGAGRGKHNQATEENVQDCGEITGW
What are the official names of this protein?
Uncharacterized protein DDB_G0274485.
What are the subcellular locations of this protein?
Secreted.
Protein: NADE_METTH
Sequence: MKCVPGLCSEVVSVIEDFIRQKVAESGASGVVLGLSGGVDSSTVAYLAVNALGPDRVLGLIMPSSTTPRDDLRHARTVADELGIESETIDIDPIIESLTGLCSHNANELALANLKPRARMVILYYHANSLNRLVAGTGNRTELLLGYFTKYGDGGVDMLPIGGLYKGQVRELAGRLGVPPEIIKKPPTAGLWHGQTDEEELGMKYDLLDELLCLLVDRKLPVEEVASTLSLPPSEVERIASMVKGSEHKLKPPEVPDIWEVMECSH
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: PUR9_GLOC7
Sequence: MGRLVLLSVSDKTGLIELARQLVEEFEFEIISSGGTAKSLQDAGIPVIKVGDYTGSPEILGGRVKTLHPRIHGGILARRDVPQDLKDLDANNIRPLDLVVVNLYPFEQTIAKDNVTVAQAIEQIDIGGPAMLRATAKNFAHLTVLCNPKYYQPYLEELRQHNGETSLAFRQKMAGETFALTNAYDQAIASYFASLTPEATENPLPTRFSVAGLELQSLRYGENPHQSASWYQSGTQPTGWTAATKLQGKELSYNNLVDLEAARRIIVEFDRSEPSCAILKHTNPCGVAVGTTLAEAYNKAFNADSMSAFGGIVALNQPIDPETAKALTKTFLECVVAPGCDEEAQKILSAKSNVRVLILPDLRSGPKQTVKVIAGGLLVQASDDALDNPETWQVVTEKQPTPEMMAELLFGWKVAKHVKSNAIVVSKNRTTLGVGAGQMNRVGSVKIALETAGEAAKGGYLASDGFFPFDDSVRTAAAAGITGIIQPGGSLKDKDSIKAANELGLVMVLTGMRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: ECO1_KLULA
Sequence: MSKYRSPKTKKSIQATLQFKSTPTLVKCPKCSITYSTNSPSDLVQHKRYHDLHLNGKRWSQSWGDIINRVEALKTEKQLKYSMVSEKDKKVMSFQLPSQTLYEEDEYIVMISPKKANEVKAALDLMSIVNEELNAPHDENAFWSEVDKSGKSQGKAFIYVKKNRAVGVITIEYIENTNRGKWMVLDTKAIVPNVVPDVKLGISRIWVCRNQRQHGIATRLLEVARKKSIYGCIVNKWELAWSQPSQSGSILAKSYNAAKHRSGKLLIPCYI
What is the function of this protein?
Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together.  In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase.  Acts by acetylating the cohesin complex component SMC3 (By similarity).
What are the official names of this protein?
N-acetyltransferase ECO1, Establishment of cohesion protein 1.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ECO subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CP17A_MACMU
Sequence: MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST
What is the function of this protein?
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis.  Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways.  A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage.  The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol.  Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione.  Has 16-alpha hydroxylase activity.  Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA.  Also 16-alpha hydroxylates androgens, relevant for estriol synthesis.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Microsome membrane.
Protein: SRP54_ACIAM
Sequence: SKLLDNLRDAVRKFLTGSSSYDKAVEDFIKELQKSLISADVNVKLVFSLTNKIKERLKNEKPPTYIERREWFIKIVYDELSNLFGGDKEPKVIPDKIPYVIMLVGVQGTGKTTTAGKLAYFYKKKGFKVGLVGADVYRPAALEQLQQLGQQIGVPVYGEPGEKDAVGIAKRGVEKFLSEKMEIIIVDTAGRHGYGEEAALLEEMKNIYEAIKPDEVTLVIDASIGQKAYDLASKFNQASKIGTIIITKMDGTAKGGGALSAVAATGATIKFIGTGEKIDELEVFNPRRFVARILGMGDIETILEKIKEVENYDKMQKKMEEVISGKGKLTLRDVYNQLIALRKMGPLSKLFQLLPGIGMLGQIPEDQLKVGEEKMRKWLAIMNSMTYEELDNPSIIDKSRMRRIALGSGTEIEDVKELIEHYNLMQRTIKMLKRRKKDVEKLLGQFGGEST
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle 54 kDa protein, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: YP077_YEAST
Sequence: MKDLQKKSSVRRQITNEDDERYGEDSIHDLPRTIPNVNPYIRNSGFRPSYSSQIPSTRSLFNNYYNRSSANTVGNDTIDTDSVSYNGVAKFRRNSVDIPLQTHNRLEVRPIIDRQDYLWREIDALDDVKRQAQATELYDQFPPGFENKLMQLRQAHSKLLQVLRDRNAKIEEEQRREVAVATAAAMMTRTPSPTGKSVGDEATSNNMHSSSAIRNPNGPTVDPEEGKYIQELVNTIRELQ
What are the official names of this protein?
Uncharacterized protein YPL077C.
Protein: LRC17_MOUSE
Sequence: MRIVAILLLFCLCRAAEPRKSSPGVLRSQGNPSRSHGRGGRRGSSPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPDWPQDLLHMLLARNKIRVLKNNMFAKFKRLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEAFIYTPLLSYLRLYDNPWHCTCELETLISMLQIPRNRNLGNYAKCGSPPALRNKKLLQLKPQELCDEEEKEQLDPKPQVSGIPAVIRPEADSTLCHNYVFPIQTLDCKRKELKKVPSNIPPDIVKLDLSSNKIRQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLIHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYSIHYLYYWLKHHYNVHYNGLECKTPEEYKGWSVGKYVRSYYEECPKDKLPAYPETFDQDTEDDEWQKIHRDHPAKKHRVRITIVG
What is the function of this protein?
Involved in bone homeostasis.  Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors.
What are the official names of this protein?
Leucine-rich repeat-containing protein 17.
Protein: DCTA_SALHS
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHYYPELGAQMKPLGDAFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAQAVAVYAAQAKEQGIIAFLMDVIPGSVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGSLVQLGQLIICFYITCILFVVVVLGTIARVTGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSHMDIFHQITLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATVVVAKWVKELDHQKLDDVLNNRAPDGKTHEISS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DSD1_YEAST
Sequence: MSDVLSQYKGCSVRDLPTPNFVINEEKFDKNCTTMLNNVEKLSQECGVPIKFRAHVKTHKTAKGTLKQLGHGLPLAKRTTRAILVSTLKEAEELLNYQDRQCSDYIDDITYSLPCCVPEFIPLLSNLSRRVNNFQVFVDNIEHLENLKNFGRPASGKKWSVFIKVDMGTKRAGLAFDSPEFLSLLKKLTSSEIKEVIEPYGFYAHAGHSYSSTSINDTQNLLMEEVKAVNSAAKVLCSVDPQFDPSKLTLSVGATPTSNSLKLDNKSTLVKFITTQLVSTLEIHCGNYCMYDLQQVATGCVQDHELSGFVLGTVLSSYPSRGELLSNTGVMCLTREASSIKGFGICADLEHVLKSESFSREWYVARVSQEHGILRPIRNWNETTPLKLGSKIAVLPQHACITMGQFPYYFVVNSEGIVNDVWLPFQKW
What is the function of this protein?
Catalyzes the conversion of D-serine to pyruvate and ammonia (PubMed:17869212, PubMed:17937657).  May play a role in D-serine detoxification (PubMed:17869212, PubMed:17937657).
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the DSD1 family.
Protein: CAIE_ECO45
Sequence: MSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCIMHGYCDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFRGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHAALHETQPLRQMEENRPRLQGTTDVTPKR
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: KDSA_ECO27
Sequence: MKQKVVSIGDINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTFGVKIITDVHEPSQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFKEGGNEKVILCDRGANFGYDNLVVDMLGFSIMKKVSGNSPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEAHPDPEHAKCDGPSALPLAKLEPFLKQMKAIDDLVKGFEELDTSK
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_CLOP1
Sequence: MHIKPEEITSIIKNEIKNYEKELETVDSGTIIQIGDGVARVYGLEECMEGELLEFPNQVFGMALNLEQDNVGCVLLGSEEGIKEGDIVKRTGKIVEVPVGEDLIGRVVNSLGQPIDGKGPIKNDGYRAIEVPAPGILERSSVNEPLQTGIKAIDSMIPIGRGQRELIIGDRQTGKTAIAIDTIINQKGKDVICIYVAIGQKQSTVANIVNTLTEEGAMDYSIVVTASASESAPLQYIAPYSGCTMGEYFMNKGKHVLIIYDDLSKHAVAYRTMSLLIRRPPGREAYPGDVFYIHSRLLERAAKLSKENGGGSLTALPIIETLAGDVTAYIPTNVISITDGQIFLETELFNAGQRPAVNPGISVSRVGGNAQIKAMKQVSGTLRLELAQYRELASFAQFGSDLDKDTQARLEKGKRLIEILKQDQYKPMAVEKQIMIIYAAVNNFLLDIKVSDIKRFEKEFLEYMDTHHREIGKAILDKKVLDDELKSALESAIVEFKKIFLM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PYG7_ARATH
Sequence: MFESNMVLQTLSSSSPPIHRLYLHHSQILPSSGSPSKISLQIHGRTLAIRSFHDYVFAEISARGLPALNKASLKKLPIKGSTFLLGQSLLMVSAHPQLAAAAEIIKPEPIYEVGELFELSIQLSYLLLLLGLLGVGTFYVIRQVLVRRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQKWDGDDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVARPRRDALKDRVKLYKGVVAVKSKKR
What is the function of this protein?
Nuclear genome-encoded factor required for the accumulation of photosystem I (PSI).  Functions as PSI biogenesis factor (PubMed:16679416, PubMed:28522455).  Cooperates with PSA3 to promote the stable assembly of PSI in the thylakoid membrane.  May target primarily the PsaC subunit (PubMed:28522455).
What are the official names of this protein?
Tetratricopeptide repeat domain-containing protein PYG7, chloroplastic, Protein PALE YELLOW GREEN 7.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Copurifies with PSI.
Protein: FRDD_VIBVY
Sequence: MKPNYNVDRAPKRSDEPVWWSLFGAGGTWFAMITPVTVLVLGILVPMGVINAEALSYDRVVSFATSIIGALFIIATLALPMWHAMHRVHHGMHDLKFHTGVVGKIACYAIAGLISALAVVFIFML
What is the function of this protein?
Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.