PharMolix/UniProtQA huggingface dataset:
Protein: RBL_NEOHI
Sequence: MSQSVESRTRIKSERYESGVIPYAKMGYWDADYVIKETDVLALFRITPQPGVDPIEASAAIAGESSTATWTVVWTDLLTACDLYRAKAYRVDPVPNVADQYFAYIAYDIDLFEEGSIANLTASIIGNVFGFKAVKALRLEDMRMPVAYLKTFQGPATGLIVERERMDKFGRPFLGATVKPKLGLSGKNYGRVVYEGLKGGLDFLKDDENINSQPFMRWKERFLYSMEGVNKASAAAGEIKGHYLNVTAATMEDMYERAEFSKEVGSIICMIDLVIGYTAIQTMAIWARKHDMILHLHRAGNSTYSRQKNHGMNFRVICKWMRMAGVDHIHAGTVVGKLEGDPLMIKGFYNTLLESETDINLPQGLFFAQNWASLRKVVPVASGGIHAGQMHQLLDYLGDDVVLQFGGGTIGHPDGIQAGATANRVALESMVMARNEGRNYVAEGPQILRDAAKTCGPLQTALDLWKDISFNYTSTDTADFVETPTANI
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DNLJ_PSEA7
Sequence: MTDTQAAAERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEHPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSLGNAFEEQDLLDFDRRVREGLADLLPGGDLLGGGAEVEYSCEPKLDGLAVSLLYENGQLVRGATRGDGSTGEDITSNVRTIRNVPLKLHGEGWPDILEVRGEVFMSRAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGRVSGTLPDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAIAHKFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQVVLERRPADAQPIEVPEHCPVCGSAVERTQLVRRSKGRESLSEGAIYRCVGRLSCQAQLKQAIIHFVSRRAMDIDGLGDKIVEQLVDRGLVASPADLYTLTYDQVFELEGFAELSTNNLLAAIADSRTPSLARFIFALGIPDVGEETAKLLARSLGSLERIGKALPEVLTYLPDVGAEVAYEIHNFFADEHNRQVIAQLRDAEHGVQLQEEGEVAAEFAACASLAGFIDKLNIPFIAATGAEKLASRFGSLDGIIRADWLDLRQVERLPERAAKSLRDFLDEPANVQRALAIEAQLREFGMHWQSERKAVEGLPLAGQTWVLTGTLEAMSRDVAKEKLEGLGAKVAGSVSARTHCVVAGPGAGSKLAKANELGLKVLDEDGLLKLLDEYGVAH
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: SPT5_ASPFU
Sequence: MSRNFLNEDFGSEEEDDDFNPAPAEDSDEEDVKPQSTSRGRINEEEEDDDHADVKPERADREGSEDDVKEDIDADEADAGGERDEGEDEEEGENDEDDEDDEEEGEEEEEDEDDEDEDEDEDEQDVSSGRPRKRRKRLGGVHNFIDTEAGVDEEEDEAEDEEDEMEFGAEMHPDDLDALPAGADTDDRRHRQLDRQRELEASMDAEKQAQLLKERYGRNRAAATDAVVVPKRLLLPSVDDPSIWGVRCKAGKEREVVFAIQKRIEERPPGSRKPIRIISAFERGGAMSGYIYVEARRQADVMEALEDMSNVYPRTKMILVPVREMPDLLRVQKSEELNPGGWVRIKRGKYQGDLAQIEEVDTNGLDVTVRLVPRLDYGLNEDSGAPVVDIKRKRPGMASGGPRPPQRLFSEAEAKKRHGKYLSATSGLGGKSWSYLGETYIDGFLIKDMKVQHLITKNVNPRLEEVTMFARGSDDGTSNLDLASLAETLKNSTAEESYLPGDPVEVFRGEQQGLVGRTTSTRGDIVTLQVTEGELAGQMIEAPVKSLRKRFREGDHVKVIGGSRYQDELGMVVQVKDDTVTLLSDMSMQEITVFSKDLRLSAETGVDGKLGMFDVHDLVQLDASTVACVVKVDRESLRVLDQNGSIRTVLPSQIANKITPRRDAVATDRNGAEIRIGDTVRELYGDQRSGVILHIYRSFLFLHNKAQAENSGIVVVRTTNVVTVSAKGGRSTGPDLTKMNPALMRSGIPGASMGPPKSFGHDRLIGKTVQVRKGPYKGLVGIVKDSTDVQARVELHSRNKLVTIPKDVLIVKDPVTGQTLDMSRKGGQRVPYGASAAPPSGWSGGRTPMAAADSSRTPAWGGASSARTPAWAGISGSRTPAWKMDGSRTSNPYDGSRTAYGGAGSRTPAWNAGARTPYDSGSGSSGFDAFAAGSRTPAWGGANAGGRTPAWSASSSAGSGNRDSRGYDAPNPGGAYSAPTPGAYTAPTPGASAPTPGAWADSAPTPGVFNAPTPGGLSGRPYDAPTPAMGGAAATPGAGAYGDGEDGGPRYDEGTPSP
What is the function of this protein?
The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing.  This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
What are the official names of this protein?
Transcription elongation factor spt5, Chromatin elongation factor spt5.
What is the protein family that this protein belongs to?
Belongs to the SPT5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LKA41_PICST
Sequence: MSKFENISKRSHELDPCTNSNYAEFKVVHTDLSLSVSFESKNISGNVIYTLKKLTKTNRLVLDTSFLEVSTAKVNGKEVVFELLPHKAPFGSPLVIPIDGENESLTVEVDFRTTDKCTAIQFIQGDTGPYVFSQCQAIHARSLFPCFDTPGVKSPYKFTAKSPSVCTMSGRPQPSNEAGVYHFDQPIPIPSYLVSITSGNLHKAPIGPRSDVYSEEPSLKDCQWEFEKDMENFIQIAEKIVFEYEWSRFDSLVLPSSFPYGGMEIPNMTQLTPTLISKDRTQVKVMAHELAHSWSGNLVTNCSWEHFWLNEGWTVYLERRIIGAIAAAEAQEEGRANPEKYGEQVRHFNAIIGWNALVETVESFDPKFTSLVWDLASGDPDDAFSRIPYEKGFNFLFHIETKVGGTKEFDPFIKHYFKKFRYQSLNSAQFIETLYDFYTPLGKKDALDTIDLEKWLFQPGLPDDPKFDTTLADQVYVLVEKWVDFVKSGETEVKFSEADVKEFEGEQEMLFIETLTDRFKDLDVSPELIRKLPSIYPKYAASKNGEVLARWNELLIKYGNYTSSDEQVKFFADWLGTVGRMKYVRPGYKLLQTSVSIEFAVETFKRFEDKYHPICKTMVQKDLNLA
What is the function of this protein?
Aminopeptidase that preferentially cleaves di- and tripeptides.  Also has low epoxide hydrolase activity (in vitro).  Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
What are the official names of this protein?
Leucine aminopeptidase 2-1, Epoxide hydrolase, Leukotriene A-4 hydrolase homolog 1, LTA-4 hydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: COBQ_MYCTO
Sequence: MSGLLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNNSMVCRGPDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLMGKPWGEVASSSWCAGRRALAEAACRAFDALAARYDVVVAEGAGSPAEINLRAGDYVNMGLARHAGLPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAGFVVNKFRGDSDLLAPGLRDLERVTGRRVYGTLPWHPDLWLDSEDALDLQGRRAAGTGARRVAVVRLPRISNFTDVDALGLEPDLDVVFASDPRALDDADLIVLPGTRATIADLAWLRARDLDRALLVHVAAGKPLLGICGGFQMLGRVIRDPYGIEGPGGQVTEVEGLGLLDVETAFSPHKVLRLPRGEGLGVPASGYEIHHGRITRGDTAEEFLGGARDGPVFGTMWHGSLEGDALREAFLRETLGLAPSGSCFLAARERRLDLLGDLVERHLDVDALLNLARHGCPPTLPFLAPGAP
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity).
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: NTE1_CHAGB
Sequence: MDVVNSTARAAVTSATAVTAVTGTGDRHPNPLSSAVAAASDVANAHGSSSWLGLFARVVLWLLQFVSMVLYYAIKLATISVPTLLYTLFSTSLTVTMNATTLMLIVAAMIGAISWVVRYRYLNMYSRLPPEPQRKEPDVDLFPDTHEEGIKSGLSNYFDEFLSAIKIFGYLERPVFHELTRSMQTRKLIAGESFNLEEEKGFCLVVDGLVEIFVKSSSYNRRYPHGPYFSPNSEAPSSDDEHPAPGQQRYQLLTEVRNGAPMSSLFSIMSLFTEDVPLRHADEDNSEPGTTTHSGLFPNYPASADFRKSRVRMDSVPNTPQMDASASSSANNLPGQLDRGLPHVPPISLDGTGFSKPQRPVPKRSNTTSAHPDIIARATVDTTVAIIPASAFRRLIKIYPKATAHIVHVILSRFQRVTLATAYNYLGLTNEVLQIERQMLKYTTQQLPNHLRGDALDRLKEKFKREVERMGEEDDVSKGIALHNARAGRRRRSTATLRKEAALQAFSKQRNISSMSGSSLAIPNAGDLVTHLQQSRGGGNRAQSVAFTDGPSPHLDVEREAVSPLAQRTFDPFVTPRSIHVALEKRETLDEDNLFRESILECMFRSIGLTGSGGSNKDADSNQASPRLISFDQRRQKALYTNHAFGFMDGLDGSADGDTESITSAGLSLPASPNPQFLAQEMRDEMEIVFFPKGSVLVEQGERNPGLYYVVDGFLDICTQEDAAASDVVHPTSRTSLHAMDSAQSIRSPQRSPQPFAESMRSGNKVDDAEIKSKPNRRSVALIKPGGLAGYVGTISSYRSFIEVVAKTDVYVGFLPLTSIERIVDRYPIVLLTMAKRLTNLLPRLILHIDFALEWLQVNAGQVIFHEGDESEAIYIVLNGRLRLVEDRKDGGMNVKAEYGQGESIGELEVLTETSRSGTLHAIRDTELVKFPRTLFNSLAQEHPNITIKISKIIASRMRALIDDPSTMLGIKDSSGRSSINKSSTTLNLRTVAVLPVSAGVPVVEFSNRLLSALTEVGAPNGATSLNSAAVLNHLGKHAFNRMGKLKLSQYLADLEEKYGLVIYVADTNVNAPWTQTCVAQADCVLMVGLADGSPEIGEYERFMLGMKSTARKILVLLHQERYSNSGLTRKWLKNRVWINGGHFHVQMTYSPNAVPIHPPAKPSGPTLRERVQILQAEIQKYTSRKVRHSPFYSPDAPFKGDFHRLARRLCGKSVGLVLGGGGARGIAQIGIIRAMQEAGIPIDIVGGTSIGAFIGALYARHADFVPIVNAAKKFSGRMASMWRFALDLTYPSASYTTGHEFNRGIFKAFGNTQIEDFWLDYYCNTTNISKSRAEFHTSGYAWWYVRASMSLAGLLLPLCDEGSMLLDGGYVDNLTVSHMKSLGSDVIFAVDVGALDDNTPQAFGDSLSGMWAFFNRWNPFSSVANPPTLAEIQARLAYVSSVDALERAKTLPGCIYMRPPIEEYGTLDFGKFMEIYGVGYKYGQEFLAKLRERGGVLPIGEEMGGKKGLRRTMAPRRASI
What is the function of this protein?
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho).  Plays an important role in membrane lipid homeostasis.  Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
What are the official names of this protein?
Lysophospholipase NTE1, Intracellular phospholipase B, Neuropathy target esterase homolog.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SY111_ORYSJ
Sequence: MNDLMTKSFMSYVDLKKAAMKDLEAGGDGVELPEVGVTDERLKGFFQETEAVEEEMAAIRDALARLNAANEEGKSLHQPDALRALRGRVNADIIAVLRRARDIRARLEAMDRANAAQRRLSAGCREGTPLDRTRTALTAALRKKLKDLMLDFQALRQRIMSEYKDTVERRYYTLTGEVPEEEVIERIISEGRSEELLCAAVAEHGKGAVLATVHEIQDRHDAAREVERSLLELHQVFLDMAVVVESQGEQLDDIERHVNSATTYVQGGNKELRKAREHQRSSRKWLCIGIIILLLLVLLVIVPIATSFKRS
What is the function of this protein?
Vesicle trafficking protein that functions in the secretory pathway.
What are the official names of this protein?
Syntaxin-111, OsSYP111.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
Protein: NIFW_FRAAA
Sequence: MSATTDAGQLAAFHRCSTAEEYFTLLEVDYDPRVVAVNRLHILKHFAGELAKLPEAGADAANPRHLLHDYRDALVRSYEAFTNATALDHRLFKVLKDRAPKSAFVPASEITVERLGSTQPSETSEQTEEAR
What is the function of this protein?
May protect the nitrogenase Fe-Mo protein from oxidative damage.
What are the official names of this protein?
Nitrogenase-stabilizing/protective protein NifW.
What is the protein family that this protein belongs to?
Belongs to the NifW family.
Protein: RAPA_PECCP
Sequence: MPFTLGQRWISDTESELGLGTVVAVDTRMITLLFPASGENRLYSRSDAPITRVMFNPGDTVTSHEGWQLKVDDVREEKGLLVYCGQRLDDETSAELREVFLDSKLTFNKPQDRLFAGQIDRMDRFALRYRARKHQNEQALQQWGGLRGMRASLIPHQLHIAHEVGQRHAPRVLLADEVGLGKTIEAGMIIHQQLLAGRASRVLIIVPETLQHQWLVEMLRRFNLLFSLFDDERYAEAKLDSSNPFETEQLVICSLGFVQRNAQRFAQLVNADWDLLVVDEAHHLVWSEESPSAEYQAVETLARATPAVLLLTATPEQLGQQSHFARLRLLDPNRFHDYQEFLAEQQQYRPVADAVTLLLAGEKAQTAELNALSDLLGEQDIEPLLKAINSDSDDNQKARQELIAMLMDRHGTSRVLFRNTRQGVKGFPQRILHQIRLPLPSQYQTAIKVSGIMNANKTLEVRARDMLYPEQIYQQLEGDDATWWNFDPRVEWLLNYLTANRDEKVLVICAQAATALQLEQVLRTREAIRAAVFHEGLSILERDRAAAYFASEEEGAQVLICSEIGSEGRNFQFASHLVMFDLPFNPDLLEQRIGRLDRIGQAKEIQILVPYLENTAQAMLVRWYHEGLDAFEHTCPTGRTIYDAHHAQLIERLTTVGEQQGLDEFIHTCRQQHDNLKQQLEQGRDRLLEMHSNGGEQAQLLAQAIAEQDNDVNLVTFALNLFDIVGINQEDRSDNLIILTPSDHMLVPDFPGLPQDGCTITFDRDQALSREDAQFISWEHPLIRNGLDLVLSGDTGSCAVSLLKNKALPVGTLLAELVYVVEAQAPKHLQLTRFLPPTPVRLLMDRKGTNLAAQVEFESFNRQLNAVNRHTSSKLVNAVQADVHAMLQQAEALVEAQARQLITEAQEQADLQLRRELERLEALKAVNPNIREDELTALESQREQVLSNLHEANWRLDAIRLVVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: Y3196_ORYSJ
Sequence: MAGSGSCMKKSCVCCQKYLEHLDGKMNCFVRRMTADSRRSMIMPCKFVNHFGGDFSGTIKLQSPNGILYVVEVTKCKNKTVLRCGWEAFVDAHHIEENDSLLFRCVENSRFEVLIFDSDDCEKVFSCAGIRNTCKSIQEKSSSSCDDTAESSESEGFARNQKGSFSHRRKTANLASSSEDSGEDSPSEHESVESGDLETSQEPYVLSRRSYLSEFQKEKVDALIQEIQPETTAFVAIMRKSNVQLPTPFLVISFCYAEVHFPHKSVTVTLQRPCKSKKWHPRFYKRKDARMNILRGSWVEFVKDNRVQEQDICVFVPTKDARRNFTFTVHLLRVAAAYSWGGTGVDRAGSSLGRTDVKSASEISIKEEPIDQEENVSSRNRNGVSDESEEDEDSEGPAHPPYIVPCKSHLSRLQKKIVEEKVRSFQSKFPVYVAIMKKSNVERSASRCQLELGARFAAAVHLPDRRQTVVLQRRGERWATVMQIRSGTRRLLISGWHRFVRDNRLRVGDICLFEFKTHERWRLTMAVHAIFREQCC
What are the official names of this protein?
B3 domain-containing protein Os03g0619600.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU3M_NELNE
Sequence: MNMLVTMLINTTLSFVLILIAFWLPQLNIYTEKANPYECGFDPMSSARLPFSMKFFLVAITFLLFDLEIALLLPMPWAMQTQDIKTMTLTAFILLSVLALGLAYEWTQKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NTPPA_CLOPE
Sequence: MKVILASKSPRRVEILEKIVKEFEVVQSNFDENTIDFKGDIEKYVKDLSRNKAIEVSKRLNEPSIVISADTVVFQDGKVLEKPKNEEDAFSMLSSLSGNTHKVYSGICLINTYDDTVVTDCDCTEVRFSELNPRQIRNYINSGEPMDKAGAYGIQGLGGAFVEGIKGCYYNVMGLPLNKLYKALENYDITIL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_ANADE
Sequence: MKTIVLKLGGEIVHSPELDLVARDLRTLVDGWNRVAIVHGGGPQATALQKRLGLETRMVAGRRYTDEATLEVMKYVVAGQLNVDLCARLLANGVMPVGLHGASGHAVQATRRPPRVMQGAGPEPVDLGLVGDVVGFNLPLLGDLFERRYVPVLACLGCDDAGQALNINGDTVASQLAGALRADALVLVTSTPGVLRDVKDPSSRIPRITRAEFERLVADGTISGGMIPKLEESFEVLRGGARSVVILGKLSPGDLVAAVLEPGSAGTVLE
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2006_MYCTO
Sequence: MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDYLTRRPQRTGEDHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDLTDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSHRNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANPGRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAAVTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPEAATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDGLWLAGSHGFELVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAVHYRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKALDWIGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVRHNEHGDRRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDPWTLVFHGYDPGQERLREALCAVGNGYLGSRGCAPESAESEAHYPGTYVAGVYNQLTDHIEGCTVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRSLRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDGGVHNTLVDRYRQLSSQHLTTAEIEVLADSVLLRTQTSQSGIAIAVAARSTLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSRDAATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTEELRLVRLHLLHLLQTISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLSLRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEVSQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGAELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNAYTNVMAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMFVPFHDGVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQASKQADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGSTLSAVVHAWVLARANRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDLLQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRISGRSATLTAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR
What are the official names of this protein?
Uncharacterized glycosyl hydrolase MT2062.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the glycosyl hydrolase 65 family.
Protein: ENV_HV1MN
Sequence: MRVKGIRRNYQHWWGWGTMLLGLLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATQACVPTDPNPQEVELVNVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDLRNTTNTNNSTANNNSNSEGTIKGGEMKNCSFNITTSIRDKMQKEYALLYKLDIVSIDNDSTSYRLISCNTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKKFSGKGSCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSENFTDNAKTIIVHLNESVQINCTRPNYNKRKRIHIGPGRAFYTTKNIIGTIRQAHCNISRAKWNDTLRQIVSKLKEQFKNKTIVFNQSSGGDPEIVMHSFNCGGEFFYCNTSPLFNSTWNGNNTWNNTTGSNNNITLQCKIKQIINMWQEVGKAMYAPPIEGQIRCSSNITGLLLTRDGGKDTDTNDTEIFRPGGGDMRDNWRSELYKYKVVTIEPLGVAPTKAKRRVVQREKRAAIGALFLGFLGAAGSTMGAASVTLTVQARLLLSGIVQQQNNLLRAIEAQQHMLQLTVWGIKQLQARVLAVERYLKDQQLLGFWGCSGKLICTTTVPWNASWSNKSLDDIWNNMTWMQWEREIDNYTSLIYSLLEKSQTQQEKNEQELLELDKWASLWNWFDITNWLWYIKIFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSLQTRPPVPRGPDRPEGIEEEGGERDRDTSGRLVHGFLAIIWVDLRSLFLFSYHHRDLLLIAARIVELLGRRGWEVLKYWWNLLQYWSQELKSSAVSLLNATAIAVAEGTDRVIEVLQRAGRAILHIPTRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: PETD_GLOC7
Sequence: MAVLKKPDLSDPKLRAKLAKGMGHNYYGEPAWPNDLLYVFPVVIMGTIGLVVGLAVLDPGMIGEPADPFATPLEILPEWYLYPVFQILRILPNKLLGIACQAAIPLGLMLIPFIESVNKFQNPFRRPVATTFFMIGTLVTLWLGAGAIFPIDKSLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: COX7C_PONPY
Sequence: MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLIVRHQLLKT
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7C, mitochondrial, Cytochrome c oxidase polypeptide VIIc.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIc family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: USPB_YERPB
Sequence: MISTVALFWALCVVCVVNMARYYSSLRALLVVLRGCDPLLYQYVDGGGFFTSHGQPSKQIRLVGYIFAQRYLDHHDPEFIRRCERLRGQFILTSALCGLVVVSLVALMLWY
What are the official names of this protein?
Universal stress protein B.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL21_CHLFF
Sequence: MKPYAIIQTGNKQYQVSEGDVIDVELLDGVSEGQEVVFEQVLFTFDGSKASLGTPTVSNAVVKGEMLSRVRGEKVIAYKYKRRKNYHRKTGHRQNYLRVKISNLVM
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: IF2_STRZP
Sequence: MSKKRLYEIAKELGKESKEVVARAKELGLDVKSHSSSVEEAVAAKIAASFKPAAAPKVEAKPAAPKVSAEKKAEKSEPAKPAVAKEEAKPAEPVAPKTEKVAAKPQSRNFKAEREARAKEQAERRKQNKGNNRDQQQNGNRQKNDGRNGGKQGQSNRDNRRFNDQAKKQQGQQKRRNERRQQEDKRSNQVAPRIDFKARAAALKAEQNAEYARSSEERFKQYQAAKEALAQANKRKEPEEIFEEAAKLAEQAQQVQAVVEVVPEKKEPAVDTRRKKQARPDKNRDDYDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKNKKGNNKNNRNQTPKPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGETIELLMVDYGIEAKQKVEVDNADIERFFVEDGYLNEDELVERPPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIVENGKKITFLDTPGHAAFTSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTAWGGDSEFVEISAKFNQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAVATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGDHFAVYEDEKSARAAGEERAKRALMKQRQATQRVSLENLFDTLKAGELKSVNVIIKADVQGSVEALSASLQKIDVEGVKVTIVHSAVGAINESDVTLAEASNAFIVGFNVRPTPQARQQAEADDVEIRLHSIIYKVIEEMEEAMKGMLDPEFEEKVIGEAVIRETFKVSKVGTIGGFMVINGKVARDSKVRVIRDGVVIYDGELASLKHYKDDVKEVTNGREGGLMIDCYNDIKMDDVIEAYVMEEIKR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.