PharMolix/UniProtQA huggingface dataset:
Protein: RBFA_BURL3
Sequence: MSRKRTSPNRNVQIADQIQRDLSELIMREVKDPRIGIVTIQSVELTPDYAHAKVYFTALTGDPAKTQEALNHASGHLHNLLFKRLHIHTVPTLHFHYDQTIEKAVEMSRLIKEANSTRAKDDDEADAAAKDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFDB_HALMA
Sequence: MQGNLPPEAQEKLEELQDLQQTAQQVAAQKQQAETELQESQTALDELDDIDEDSTMYREVGELLVKTEFDEAQDDLEEKVNSLEVRVETLEKQEERVQEQFEELQSELQQMLGGAGGAGPAGGPGAGGA
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_STAAB
Sequence: MTVEWLAEQLKEHNIELTETQKQQFQTYYCLLVEWNEKMNLTSITDEHDVYLKHFYDSIAPSFYFDFNQPISICDVGAGAGFPSIPLKIMFPQLKVTIVDSLNKRIQFLNHLASELQLQDVSFIHDRAETFGKGVYRESYDVVTARAVARLSVLSELCLPLVKKGGQFVALKSSKGEEELEEAKFAISVLGGNVTETHTYELPEDAGERQMFIIDKKRQTPKKYPRKPGTPNKTPLLEK
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 535 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_CUPTR
Sequence: MTAKHRGAQAEASAPAGALPADAAASRVAWLREELDRHNYQYYVLDAPTVPDAEYDALFSELMALELEHPELQTPDSPTQRVGGEPLSAFDSVRHRVPMLSLNNAFADEDVLNFDRRCAQGLGRTAPAAGEADLFSAADAVEYACELKFDGLAMSLRYEDGRLVQAATRGDGETGEDVTVNVRTIKAIPLKLRGQAPAVLEVRGEVFMFRRDFDKLNARQAEAGEKTFVNPRNAAAGSLRQLDPRITARRPLSFFAYGLGELQGVERPPTHSAMLDGFAALGLPVCKDRAVVKGAQGLLDFYRDIGKRRDDLPYDIDGVVYKVNALAEQERLGFVSRAPRFALAHKFPAQEMTTVVEDIEVQVGRTGAITPVARLRPVFVGGVTVTNATLHNEDEIRRKDVHVGDTVIVRRAGDVIPEVVAVVAERRPADARAFVMPTACPVCGSHIEKLEDEAIARCTGGLICAAQRKQSLLHFAQRRAMDIEGLGDRLVEQLVDQGIVRTPADLYKLGVAKLAALERMADKSAANLVAAIDKSRATTMNRFIFALGIRHVGEATAKDLARHFGKLDALMAADEAALLEVNDVGPVVAQSIAHFFAEPHNVEVIEQLRAAGVHWPESEPVAKSPAPLSGKTFVLTGTLPTLSREDAKELLEAAGAKVAGSVSKKTDYVVAGAEAGSKLDKAEALGVPVLDEAGMLALLAQAGAAPAEE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: SBDS_DICDI
Sequence: MSIFTPVNNKTLTNIVVVRYKKGAAKFEIACYPSKVQSYRSKIEKDLNEVIQIHRIFTNVSKGIIAKKDELIKAFGTDNEQEIILLILEKGELQVSSKERDNQSEQTFKDIATIVAEKCVNTETQRPIPVSIIEKAMKDVHYSIHPTKSSKQQSLEVIKQISSVIPIQRAQMRLNITIPTKESKTLNRDKLMVLVSKIEEEDRDGGGLSIVCLVDPGSYRKIDELIKQETKGKGFIDIINLAVAKEGETKINETGKSAPTSTTTTTTTTTSSSK
What is the function of this protein?
Required for the assembly of mature ribosomes and ribosome biogenesis.  Triggers the GTP-dependent release of ribosome maturation factors from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly.  Required for normal levels of protein synthesis.  May play a role in cellular stress resistance.  May play a role in cellular response to DNA damage.  May play a role in cell proliferation (By similarity).
What are the official names of this protein?
Ribosome maturation protein SBDS.
What is the protein family that this protein belongs to?
Belongs to the SDO1/SBDS family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (By similarity).
Protein: NTRB_ECOLI
Sequence: MATGTQPDAGQILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLVIDGRSHILSVTAQRMPDGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQADRLRNLVDRLLGPQLPGTRVTESIHKVAERVVTLVSMELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALGPEGGEIILRTRTAFQLTLHGERYRLAARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGHTEFSVYLPIRK
What is the function of this protein?
Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation.  Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC.  In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.
What are the official names of this protein?
Sensory histidine kinase/phosphatase NtrB, Nitrogen regulation protein NR(II), Nitrogen regulator II, NRII.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2850_PARDP
Sequence: MPEAMTAMDSQDERAQRLVLVTGPSGAGRSTAINVLEDLGYEAIDNLPLSLIPRLLDGPARPMPLALGVDVRNRDFSVANLIELIDRLTRLPEYAPEVLFLDCTTEQLLRRFNETRRRHPLRGEGSPLDAIRAERDMLGPIRARADVLVDTSELSPHDLKAELARWFETEPGRRLTVSVQSFSYKRGVPRGVDMMFDCRFLANPHWRTELRPLDGRDSPVQQYVMADSRFDEFFRRVRDLVLFALPAHLEEGKAHLAIGFGCTGGRHRSVTMAEKMADALAKAGWQVSIRHRELERREKAPAPGDEGHMRAARTAWAQG
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Pden_2850.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: YITU_BACSU
Sequence: METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCISTGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISESYNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEEDVPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAFGDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL
What is the function of this protein?
Catalyzes the dephosphorylation of the riboflavin precursor 5-amino-6-(5-phospho-D-ribitylamino)uracil and of flavin mononucleotide (FMN) in vitro (PubMed:26316208).
What are the official names of this protein?
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YitU.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: UREF_MYCBP
Sequence: MTSLAVLLTLADSRLPTGAHVHSGGIEEAIAAGLVTGLATLEAFLKRRVRTHGLLTASIAAAVHRGELAVDDADRETDARTPAPAARHASRSQGRGLIRLARRVWPDSGWEELGPRPHLAVVAGRVGALSGLAPEHNALHLVYITMTGSAIAAQRLLALDPAEVTVVTFQLSELCEQIAQEATAGLADLSDPLLDTLAQRHDERVRPLFVS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFEO_ECO45
Sequence: MLHPRARTMLLLSLPAVAIGIASSLILIMVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSNEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVFVLGIGGLILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRQKQQPPHDNV
What are the official names of this protein?
Putative ion-transport protein YfeO.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACCD_DAUCA
Sequence: MERWWFDSILFKKGFEHRCGLSKSMGGLGPIENTSESEDPNRNDMKKNSHSWGSRDNSSYSNVDYLFGVKDIWNFISDETFLVVDRNGNSYSIYLDIEKHIFEIDSGHFFQSGLESSFYSYWNLSYLNNGSKTDDPHDDHYMDDTQYSWNNHINSYIDIYLESQIFIDTYIVSGSDNYSNSYISRSVCGESESKGSNISTSTNGSTIIESSNDLDITQKYRHLWVQCENCYGLNYKKILKSKMNLCEQCGYHLKMSSSDRIELSIDPDTWDAMDEDMVSLDPIEFHSEEEPYKDRIDSYQRKTGLTEAVQTGIGQLNGIPIALGVMDFQFMGGSMGSVVGEKITRLIEYATNQLLPLIIVCASGGARMQEGSLSLMQMAKISSALYDYQSNKKLFYVPILTSPTTGGVTASFGMLGDIIIAEPNAYIAFAGKRVIEQTLNKTVPEGSQAAEYLFQKGLFDLIVPRNLLKSVLSELFQLHAFFPLNKNSIEH
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: ISCS_RUMFL
Sequence: MEKRFIYADNAATTAVSEEVLSAMLPYFRTAYGNASSIYKLGRDAQRDVELAREKVAKALGAEPREIYFTSCGSESDNWAIKGTAELMAKKGKKHIVTSVFEHHAVLHTCEYLEKHGYEVTYVPVNDKGLIDPEDVRKAVREDTALVTIMYANNEIGTIQPIEEIAAVCREKGVLFHTDAVQAVGHVDIDVHKQGIDMLSLSGHKIHAQKGIGAIYIRKGIVLPNLVHGGGQERGKRAGTENVPAIVGLGVAIEAAVRNTAEKAAIIIPRRNRIIDELLKIPYTRLNGDREKRLPGNINISFEGIEGESLLLMLDLNGICASSGSACTSGSLDPSHVLLSIGLKHAVAHGSLRLSIEEDVSDEDVEYIIETIPKVVQRLRSMSPVWERMMKGEKYD
What is the function of this protein?
Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKHG5_MOUSE
Sequence: MGTGPGVSGRRAAARPSSELPSPDSQLLWVGGHAHSSDSQVCHHADCQQLHHRGPLNLCETCDSKFHSTLHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAADLEEEEEGCTDGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKPGDEGKVEQGVKDSKSLSLPALRPSGAGPPVSERVDPQSRRESSLDILAPGRRRKNMSEFLGEAGIPGHEPPAPSSCSLPVGSSGGTSSGINESWKNRAASRFSGFFSSSPSTSAFSREVDKMEQLESKLHAYSLFGLPRMPRRLRFDHDSWEEEEEDDEEDEESSGLRLEDSWRELTDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYNAQNQLQQLRAQLSAQEHPGSQHLQSLEEEEDEQEEEGEESGTSAASSPTILRKSSNSLDSEHCTSDGSTETLAMVVVEPGATLSSPEFEGGPVSSQSDESSLSNTASSVTPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPHPVVEPAPVPQTPSPQPSPRLRRRTPVQLLPRPPRLLKSKSEASLLQLLSGTPAARGVPPAPSRSLSELCLISVAPGVRTQRPLQEGGPGWNGPGMCDPCHGPQLSESENRPSHMTGGPADSARRRCREMPSGTMSRVQSEPPSGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
What is the function of this protein?
Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (PubMed:29084947).  Involved in the control of neuronal cell differentiation.  Plays a role in angiogenesis through regulation of endothelial cells chemotaxis (PubMed:21543326).  Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity).
What are the official names of this protein?
Pleckstrin homology domain-containing family G member 5, PH domain-containing family G member 5, Synectin-binding RhoA exchange factor, SYX.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Cell junction. Cell projection, lamellipodium. Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane (PubMed:16467373). Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (PubMed:21543326).
Protein: THIC_ZYMMO
Sequence: MADISDQNIPGHVTTGPIRGSRKIYVEGKNGVRVAMREIDLEPSANEQPVRVYDCSGPYTDPNIKIDIAAGLKPLRREWILARGDVESYEGREIKPEDNGQLGPDRSGGVPPFPNVNHHPLRAKAGANVTQMHYAKKGIVTSEMEYIAIRENCGRAQMKEAMIRDGESFGANIPDFITPEFVRDEIAEGRAVIAANINHPEAEPMIIGRNFLVKINANIGNSAVASDVAAEVEKMVWAIRWGADTVMDLSTGRNIHDTREWILRNSPVPIGTVPIYQALEKVNGIAENLTWEVFRDTLIEQAEQGVDYFTIHAGVRLAYIPLTANRITGIVSRGGSIMAKWCLAHHQENFLYTHFEDICEILKRYDIAFSLGDGLRPGCIADANDRAQFAELETLGELTKIAWKHDVQVMIEGPGHVPMHKIKPNMDKELVACHEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAMLCYVTPKEHLGLPDRDDVKVGVVTYKLAAHAADLAKGHPTAHFRDNALSRARFEFRWKDQFNLSLDPDTAESFHDQTLPAEGAKAAHFCSMCGPKFCSMKITQEVREFAAQGMEEMSDQFKEKGGEIYLPAAE
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: SGAT_MAIZE
Sequence: LDYVYGPGRRAMNSPAVPALTKVLLEDVKKALTNTLSPGDRLLLVDMDEWGVDVALTGSQKALSFPTGMGLVCASPRVFFDWKDYLRTYWHYDQALDLELAVEAWGLSNRYNLSLGLGLNKVAGGKVFRDVGYPVK
What are the official names of this protein?
Serine--glyoxylate aminotransferase, SGAT, Alanine--glyoxylate aminotransferase, AGT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: WOX6_ORYSI
Sequence: MEGSSNSPDRQSSGGSPPEERGGGGSGGGGGRSAAGEPVRSRWTPKPEQILILESIFNSGMVNPPKDETVRIRKLLERFGAVGDANVFYWFQNRRSRSRRRQRQMQAAAAAAAAAASSSSPSANTSPAAASAATVQVGLPPVAVVHTMAMGGSACQYEQQASSSSSSGSTGGSSLGLFAHGAGASGAGGYLQASCGASASASSALAPGLMGDVVDSGGSDDLFAISRQMGFVGSPRCSPASSPATPSSAATAAQQQFYSCQLPAATITVFINGVPMEMPRGPIDLRAMFGQDVMLVHSTGALLPVNDYGILMQSLQIGESYFLVARPT
What is the function of this protein?
Transcription factor which may be involved in developmental processes.
What are the official names of this protein?
WUSCHEL-related homeobox 6, OsWOX6.
What is the protein family that this protein belongs to?
Belongs to the WUS homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROL_SODGM
Sequence: MTQHLFMVGARGCGKTTVGQALARVLGYAFADTDDMLWRSTGKTVAEIVAKEGWTGFRARESEILTSVTQGNAVVATGGGIILSAANRRFMRARGTVVYLHATAQELSRRLRAYPEDDQRPSLTGKPMIEEIAEVLAAREKLYQEAAHHVLDASQPPDDVVSAILQQLYPSAAS
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_SALG2
Sequence: MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: LIS1_CRYNJ
Sequence: MAALSDRQKDELHRAMLAYLHAAGMHNAYAALQHDAALADVDPRDRAVGLLEKKWTSVIRLQKKVIDLENRNAALLAELAAAARPAAPGPFLPRPPPRHTLASHRAPVTRLAFHPTWTLLASASEDATVKLWDWEAGDMERTLKGHTKAVMDVDFDPRGGLMATCSSDLTLKLWDTANQYTNVKTLHGHDHSVSSVRFMPDGETLVSASRDKTIRVWQVSSGYCIKTFSGHAEWVREAVPSEDGRWLVSASNDQTSRIWDFSTGETKMELRGHEHVVECAVFAPVNAYPAIRELAGLKPPAPRDTRAKSPGVYAATGSRDKTIKLWDALSGQCLRTLVGHDNWIRALVFHPSGKYLLSASDDKTIKVWDLANGRCTKTIEAHSHFVTSMTWGRAVGASGGIEKVNGDASSKEPRRINVLATGSVDQTIKVWTP
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  Plays a central role in positioning the mitotic spindle at the bud neck during cell division.  Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
What are the official names of this protein?
Nuclear distribution protein PAC1, Lissencephaly-1 homolog, LIS-1, nudF homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules and the mitotic spindle poles.
Protein: CBPQ_RAT
Sequence: MRFLFFLFVAVVHLFSLGSGKAIYKSGVSQRTFQEIKEEIANYEDVAKAIINLAVYGKYQNRSYERLGLLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLENVHLEQVRIPHWERGEESAVMVVPRIHKLAILGLGGSIGTPPEGITAEVLVVASFVELQRRASEARGKIVVYNQPYTDYGKTVQYRERGAVEAAKVGAVASLIRSVASFSIYSPHTGHQGYQDGVPKIPTACITIEDAEMMSRMASRGDKIVIHLKMGAKTYPDTDSFNTVAEITGSKYPEEVVLVSGHLDSWDVGQGALDDGGGAFISWEALSLVKDLGLRPKRTLRLVLWTAEEQGGVGASQYYELHKANISKYSLVMEADSGTFLPTGLQFTGSDKARAIMKEVMSLLQPLNITKVFNDAEGTDINFWIQAGVPGASLRDDLYKYFFFHHSHGDTMTAMDPKQMNVAAAVWAVVAYVVADMEEMLPRS
What is the function of this protein?
Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides.  Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids.  May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
What are the official names of this protein?
Carboxypeptidase Q, Hematopoietic lineage switch 2 related protein, Hls2-rp, Liver annexin-like protein 1, LAL-1, Plasma glutamate carboxypeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Lysosome. Secreted. Note=Secretion is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin.
Protein: CHS4_MEDSA
Sequence: MVSVSEIRKAQRAEGPATILAIGTANPANCVEQSTYPDFYFKITNSEHKTELKEKFQRMCDKSMIKRRYMYLTEEILKENPSVCEYMAPSLDARQDMVVVEVPRLGKEAAVKAIKEWGQPKSKITHLIVCTTSGVDMPGADYQLTKLLGLRPYVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEVTAVTFRGPSDTHLDSLVGQALFGDGAAALIVGSDPVPEIEKPIFEMVWTAQTIAPDSEGAIDGHLREAGLTFHLLKDVPGIVSKNIDKALVEAFQPLGISDYNSIFWIAHPGGPAILDQVEQKLALKPEKMRATREVLSEYGNMSSACVLFILDEMRKKSTQDGLKTTGEGLEWGVLFGFGPGLTIETVVLRSVAI
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 4, CHS12-1, Naringenin-chalcone synthase 4.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: FLAA_HELMU
Sequence: AFQVNTNINALTTSAGATQLGLKNSLEKLSSGLRINKAADDASGMTISDSLRSQASALGQAISNANDGIGIIQVADKAMDEQLKILDTIKVKATQAAQDGQSLESRKAIQSDIIRLIQGLDNIGNTTSYNGQSLLSGQWTNKEFQIGTYSNQSIKVSVGSTTSDKIGQVRINTGAMITAASEATLTFKQINGGGTSPLEGVKISHSVGTGLGVLAEVINKNSDKTGIRAKASVETTSDKEIMSGNLKNLTINDVNIGNIVDIKKGDADGRLVQAINALTSSTGVEASTDSKGRLNLRSVDGRGIVLKADASEDNGDGKSAPMAIDAVNGGQSITDGEGAANYGRLSLVRLDARDIVLTSSDKPDENKFSAIGFGDNNVAMATVNLRDVLGKFDASVKSASGANYNAVIASGNSNLGAGVTTLVGAMLVMDIADSARKTLDKIRSDLGSVQGQMVSTVNNISVTQVNVKAAESRMREVDFAAESAEFNKYNILAQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.  Important for motility and virulence.
What are the official names of this protein?
Flagellin A.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: RIP2_GYPVA
Sequence: VVTITLNLANPSKGQYSSFVDRIRNNVRDPKLKYGGTDIAVIGAPPTREKYLRINLQGPRGTVSLGLRRENLYVVAYLAMDNTNTNKAYYFRNQITSAELRTVFPEATATNQIVIQYGEDYQSIERNAQITQGSQSRKELGLGIDLLVTSIDGVNRKARVVRNEARFLLIAIQMTAEAARFRYIQNLVTFNFPKKFDSDNKVIQFEVSWGKISRAIYGDCKNGVFNKDYDFGFGKVRQAKQLQMGLLMYLGRPG
What is the function of this protein?
Exhibits N-glycosylase activity (PubMed:35878187).  Catalyzes the release of one adenine from a ribosome (PubMed:35878187).  Acts as a ribosome-inactivating protein and inhibits protein synthesis (By similarity).  Induces cell death in Huh-7 liver cells (PubMed:35878187).  May contribute to the protection against plant pests and predators or play a role in regulating the death of plant cells (PubMed:35878187).
What are the official names of this protein?
rRNA N-glycosylase sapovaccarin-S2, Ribosome-inactivating protein sapovaccarin-S2, RIP sapovaccarin-S2, rRNA N-glycosidase.
What is the protein family that this protein belongs to?
Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.
Protein: REGX3_MYCS2
Sequence: MTSVLIVEDEESLADPLAFLLRKEGFEATVVGDGPSALAEFERSGADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRGADNDDAGADDGVLEAGPVRMDVERHVVSVNGEPITLPLKEFDLLEYLMRNSGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEEDPANPVHLVTVRGLGYKLEG
What is the function of this protein?
Member of the two-component regulatory system SenX3/RegX3 involved in stress response (PubMed:17526710, PubMed:18083811, PubMed:22956756).  The system is involved in phosphate starvation response (PubMed:17526710).  Once phosphorylated by SenX3, activates the expression of the alkaline phosphatase phoA, the high-affinity phosphate transporter pstSCAB, phnDCE, phnF and senX3 (PubMed:17526710, PubMed:18083811).  May act as a negative regulator of NhaA (PubMed:22956756).  Acts by binding to a DNA motif consisting of an inverted repeat (PubMed:17526710).
What are the official names of this protein?
Sensory transduction protein RegX3.
Protein: HIS5_LEPIN
Sequence: MIAILDYGMGNIHSCLKAVSLYTKDFVFTKDHSTIENSKALILPGDGHFDKAMENLNSTGLRKTIDKHVTSGKPLFGICIGFQILFESSEEIAQGSKKEQIEGLGYIKGKIKKFHGKDFKVPHIGWNRLQIRRKDKSVLLKGIGDQSFFYFIHSYRPTDAEGNAITGLCDYYQEKFPAVVEKNNIFGTQFHPEKSHTHGLKLLENFIRFI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.