PharMolix/UniProtQA huggingface dataset:
Protein: H2AW_HUMAN
Sequence: MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVGAPVYMAAVIEYLAAEILELAGNAARDNKKARIAPRHILLAVANDEELNQLLKGVTIASGGVLPRIHPELLAKKRGTKGKSETILSPPPEKRGRKATSGKKGGKKSKAAKPRTSKKSKPKDSDKEGTSNSTSEDGPGDGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHPTTAEIDLKEDIGKALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHCHIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLKAISAHFDDSSASSLKNVYFLLFDSESIGIYVQEMAKLDAK
What is the function of this protein?
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  May be involved in stable X chromosome inactivation.
What are the official names of this protein?
Core histone macro-H2A.2, Histone macroH2A2, mH2A2.
Protein: RIMO_ACISJ
Sequence: MSQALSPAKTPKIGFVSLGCPKNLTDSELLLTQLSAEGYETSKTFEGADLVIVNTCGFIDEAVKESLDTIGEALAENGKVIVTGCLGARAGETGGNLVKEVHPSVLAVTGPHAAQEVMEVVHTHCPKPHDPFLDLVPGGFGEAGIKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPVGDVLKEAKALFEGGVKELLVISQDTSAYGVDVKYRTGFWDGKPVKTRTLELVQKLGEMAATYGAWVRLHYVYPYPSVDDIIPLMAQGLVLPYLDVPFQHSHPDVLKRMKRPASGEKNLERILRWREACPEIVIRSTFIAGFPGETEEEFQHLLDFVREAQIDRAGCFAYSDVEGAAANELPGMLPMELREERRARFMAVAEEVSTAKLQRRVGQTMQVLVDQAVGLGKKGGVGRSYADAPEIDGVVHLLPPEKFSKTYKVGDFVKARIVGTQGHDLVGVPV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHF3_SCHPO
Sequence: MNNITKLMKQKNILTPPLPLYRRVLRAHRYHLGAEERALGDEYVKAEFRRHRNVTNPLHLVGFLSSWERYADALENESWKQEKYSNTDLLESLNDQQIGQLYELSKALQEQKKSE
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Promotes maturation of the iron-sulfur protein subunit sdh2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants.  May act together with SDHAF1.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 3, mitochondrial, SDH assembly factor 3, SDHAF3.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. SDHAF3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: EFTS_ORYSI
Sequence: MAWSQSARKPMIGLLFRAQQHGARGYSYSAFQAHLSSSNVDQSATLLRRFSSEVPASEQMNLIKQLRERTSAPIKDVKASLVSCNWDIDAAQKDLRKRGVVLAAKKSSRTAAEGLLAIAQDEKRAAVVELNCETDFVARNDVFQYLASSLAKLALSARDPGELVFPFGPDYLEVNLNVNLDHPKLSGETTVQSAVTELAAMVGENVKFRRGFIMSTTAHGVVCSYMHTCPQPGLGRLAGLITLEAEDSNAPLDALQRVGKSIAMHIVATKPLFLSKELVSASAVENERDILRTQAESSGKSQMAMEKMVEGRLRKYFEEVVLLEQKYVVNDSTNIKSVLNDLSKEVGSKVTVGNFARMEVGEGVSKLFQQILIVTRKRKEWILSK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, mitochondrial, EF-Ts, EF-TsMt.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FOLD2_SALTO
Sequence: MTATLLDGKATAAEIKDELRVRVKALAERGVTPGLGTVLVGADPGSQAYVNGKHRDCAEVGVASLRRELPTDATQEQVDAVLADLNNDPACHGYIVQLPLPAHLDTQRVLELIDPDKDADGLHPVNLGRLVLGYPGPLPCTPRGIVELLRRHDVALRGARVVVIGRGNTVGRPLGLLLTRRSENATVTLCHTGTLDLTAHTRAADIVIVAAGVPGLLTSDMITPGAVVVDVGITRVIGPDGKGRYTGDVDPGVGEVAGALVPMPGGVGPMTRAMLLTNVVERAERG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 2.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PMT5_YEAST
Sequence: MNKEHLLKVDPIPDVTIKRGPLRSFLITKPCDNLSSLRTVTSSKEKLLVGCLLIFTAIVRLHNISLPNSVVFGENEVGTFVSQYVNNIFFTDVHPPLVAMLYATVSSVFGYKGLFNYGNIGTEYTANVPYVAMRFFSATLGIVSVLVLYLTLRVSGVKIAVAAICAVCFAIENSFVTLSRFTLIEGPFVFFMACAVYFFRRSELYLPNSCKANKSLLAASIALGFAVSSKWAGLFTIAWAGIIVLWRVWFMIGDLSRPIGSSIKYMAFQFTCLLAIPAFIYFLIFSVHIKTLNVNGISSSFFPAEFRKTLKYNNVIKETVAEVAVGSAVSLNHVGTAGGYLHSHLHNYPAGSMQQQVTLYPHIDQNNKWIIELAEHPNENVTSFQNLTDGTIIKLRQLKNGCRLHSHDHKPPVSQNADWQKEVSCYGYEGFEGDINDDWIIEIDKKRSEPGPAQEHIRAIETKFRLKHYLTGCYLFSHPEKLPEWGFGQQEVTCAYFAREDLTSWYIEENENEISLPNPEKVSYKKMSFWQKFVAIHKFMFYLNNYMDTSHAYSSEPKTWPLMLRGIDFWNENGREVYFLGNAVLWWSVTAFICTFIIGVAVELLAWKLGVNILRDKHIINFHYQVFQYLLGFAAHYFPYFFVGQKLFLYDYLPAYYFGILAFGHALDLISTYISNKRNNTGYIVVAIFMVVCFYFFSEHSPLIYATGWSSNLCKRSKWLGSWDFYCNSLLLSDSHYELNAES
What is the function of this protein?
Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity.  Forms a heterodimeric complex with PMT3 and more rarely with PMT2 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins.
What are the official names of this protein?
Dolichyl-phosphate-mannose--protein mannosyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 39 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PYRR_BACC3
Sequence: MQEKAVVLDDQMIRRALTRISHEIVERNKGVDNCVLVGIKTRGIFIAQRLAERIGQIEGKEMEVGELDITLYRDDLTLQSKNKEPLVKGSDIPVDITKKKVILVDDVLYTGRTVRAAMDALMDLGRPSQIQLAVLVDRGHRELPIRADYVGKNIPTSSEERIEVDLQETDQQDRVSIYDK
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: DOF41_ARATH
Sequence: MDHHQYHHHDQYQHQMMTSTNNNSYNTIVTTQPPPTTTTMDSTTATTMIMDDEKKLMTTMSTRPQEPRNCPRCNSSNTKFCYYNNYSLAQPRYLCKSCRRYWTEGGSLRNVPVGGGSRKNKKLPFPNSSTSSSTKNLPDLNPPFVFTSSASSSNPSKTHQNNNDLSLSFSSPMQDKRAQGHYGHFSEQVVTGGQNCLFQAPMGMIQFRQEYDHEHPKKNLGFSLDRNEEEIGNHDNFVVNEEGSKMMYPYGDHEDRQQHHHVRHDDGNKKREGGSSNELWSGIILGGDSGGPTW
What is the function of this protein?
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
What are the official names of this protein?
Dof zinc finger protein DOF4.1, AtDOF4.1.
What are the subcellular locations of this protein?
Nucleus.
Protein: HDA_YERPS
Sequence: MLLNTPAQLSLPLYLPDDETFASFYPGENPSLLAAIQSAVHQPHGSYIYFWSREGGGRSHLLHAACAELSQQGEAVGYVPLDKRAYFIPEVLEGMEQLALVCIDNIECIAGDEQWEMAMFNLYNRIVETGRTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDDEKLQALQLRAKLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILSL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: CM4B_CONPE
Sequence: MMSKLGVLLIICLLLCPLTAVPQDGDQPADQPAERMQDDISSEHHPFFDPVKRCCKYGWTCWLGCSPCGC
What is the function of this protein?
Mu-conotoxins block voltage-gated sodium channels (Nav).  Blocks reversibly sodium channels in molluskan neurons, but has no effect on sodium currents in bovine chromaffin cells or in rat brain synaptosomes.  Induces paralysis in bivalve mollusks (Mytilus).  No effect are observed on fish (Gambusia) and fly larvae (Sarcophaga).  Is approximately 6 times more potent than PnIVA in blockade of the sodium current in Lymnaea neurons.
What are the official names of this protein?
Mu-conotoxin PnIVB.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GLYA_ACTP2
Sequence: MFTANMNIQDYDPILWQAIENENRRQEEHIELIASENYASPRVMQAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAIDRAKQLFGADYVNVQPHSGSQANAAVYGALIQPNDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITAEGLIDYEDVRQKALECKPKMIVAGFSAYSQIVDWAKMREIADEVGAYLFVDMAHVAGLIAAGVYPSPLPYAHVVTTTTHKTLGGPRGGLILSACGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPEYKIYQQNVVKNAKAMVEVFKQRSYEVISNGTENHLFLVSFVKQGLTGKAADAALGQANITVNKNSVPNDPQKPFITSGIRIGTPAVTRRGFKEADVQALAGWMCDVLDSIGKDNHEQVIAETKAKVLDICARLPVYAK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_XANC8
Sequence: MSVVVRHDWDRKELHALFALPFPELLHRAASVHRAHFDPAEVQVSTLLSVKTGGCPEDCAYCPQAQRYDTGVSAQKLMDTEDVVAKARQAKAAGASRFCMGAAWRSPKDRDIPKVAAMIREVKAMGLETCATLGMLDAGQARALKDAGLDYYNHNLDTAPDYYDSIIHTRQYQDRLNTLEHVRDVGLKTCCGGIVGMGETREHRVGLLHALATLPAHPDSVPINQLVQVPGTPLHGTEPLDAFEFVRMIAVARIAMPKSMVRLSAGREAMSDELQALCFLAGANSIFYGEKLLTTGNPDTERDQGLFQRLGLRPMQITVDAAEHDHPGTVHADITCGAACEHAA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: CYSD_BRUA4
Sequence: MHHASLTKNLTHLQRLEAEAIHIFREVAASFSNPVMLYSVGKDSSVMLHLAMKAFYPAPPPFPFLHVDTTWKFREMIEFRDAQAREKGFELLVHINEDGVREGVGPFSHGSNVHTHVMKTVALRQALDKYKFDAAFGGARRDEEKSRAKERIFSFRSAQHGWDPKNQRPEMWKIYNTRVSAGESIRVFPLSNWTELDIWQYILQENIPIVPLYFAAHRPVVERDGMLIMLDDDRMKLRPGETVENRLVRFRTLGCYPLTGAIESSAADLSDIVEEMLIARTSERQGRAIDRDEAGSMEKKKREGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: MT2_MALDO
Sequence: MSSCCGGKCGCGSVCSCGSGCNGCGMAPDLSYMEGSTTETLVMGVAPQKSHMEASEMGVAAENGCKCGDNCTCNPCNCK
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-like protein type 2.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
Protein: YL434_YEAST
Sequence: MLSHQYIVCSLFRKDYHYKNFSQISLDSTFLPVAINTNCLNHFDIHLYLFQNFSCHRLLKHEFSNSEKERTTGKQKGKMYKSFNVFESRGIIIKERSKAFNICFIKGIIQRKVFLDSFFFDVLAQLP
What are the official names of this protein?
Putative uncharacterized protein YLR434C.
Protein: LPXD2_SULDN
Sequence: MLLSSIAQHLKLPFFGEDLELDSMNELALSLPSQLTFAINKKYSQELESSKSKAFLIIDTLVENLPKESSYIICPDVSISMAQATKLFNKRPIEPQLPSATIGEGSMIDSMVRVENGTCIGSNVIVMAGAYIGANCVIGDDTTIYPNVTIYRDTIIGKECIIHAGVVIGADGFGFSHTKEGEHIKIYQNGNVIIEDCVEIGANCAIDRAVFNSTIIRRGTKLDNFIHIAHNCDIGEHSIFVAQTGVGGSTKLGRNCVVSGQSAFSDHLNIAPFSTFSARSGVTKSIEKSGGVYSGFPLMNHKEWKRLQVKIARLND
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: FABZ_IDILO
Sequence: MKITESGFDIQGVLDLLPHRYPFLLIDRVIETNSKDSLHAIKNVTFNEPMFNGHFPAKPIFPGVLLLEAIAQACGLLGFKITESKKNANDLYLFAGIDNARFKRQVIPGDTVDFFVTFEKERRGIWKFTGRAEVDGDVACTAEIICARREV
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG21_YEAS7
Sequence: MKVLQFNQDATCCVVAASSHQISIFNCDPFGKCFEIDTKNSKKKTSNNNGTASNSESRNNEESILITNGSRDRTDAEEEEDNEDNALVTGNILKEGEFVIEMLFSTSLIAIADRGQGLNKGKKLKIVNTKRKSTICEIVFPHEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYKRSQANSFSNASNTGTLEGDSANLNRVATNLLANATQKSVNGSNPSVRTRRNSLRSKIRPRMVLSNDDRSILCFTAYSSPKKNKPNSEALYDVVIYDTLNVTPVNYLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLCNLYQLAFDKSMTMIGCVGDTDTIHLFKLDDASNSLPGDNSSNGHWNEEEDILASNSNPSMGTPKEIPLSKPRIANYFSKKIKSSIPNQNLSRNFAYITVNESNRSCLGFPDEFPNQVYIASDDGTFSIYSIPSKPGECVLTKNNKFT
What is the function of this protein?
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy.  Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure.  Protects ATG8 from ARG4-mediated cleavage.  Essential for maturation of proaminopeptidase I (By similarity).
What are the official names of this protein?
Autophagy-related protein 21.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Cytoplasm. Vacuole membrane. Note=And perivacuolar punctate structures.
Protein: FRDC_HELPY
Sequence: MQQEEIIEGYYGASKGLKKSGIYAKLDFLQSATGLILALFMIAHMFLVSSILISDEAMYKVAKFFEGSLFLKAGEPAIVSVVAAGIILILVAHAFLALRKFPINYRQYKVFKTHKHLMKHGDTSLWFIQALTGFAMFFLASIHLFVMLTEPESIGPHGSSYRFVTQNFWLLYIFLLFAVELHGSIGLYRLAIKWGWFKNVSIQGLRKVKWAMSVFFIVLGLCTYGAYIKKGLENKENGIKTMQEAIEADGKFHKE
What is the function of this protein?
The fumarate reductase enzyme complex is required for fumarate respiration.  This subunit anchors the complex in the membrane and binds a diheme cytochrome b.
What are the official names of this protein?
Fumarate reductase cytochrome b subunit, Quinol-fumarate reductase cytochrome b subunit, QFR cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the diheme cytochrome b FrdC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YAII_ECOSM
Sequence: MTIWVDADACPNVIKEILYRAAERMQMPLVLVANQSLRVPPSRFIRTLRVAAGFDVADNEIVRQCEAGDLVITADIPLAAEAIEKGAAALNPRGERYTPATIRERLTMRDFMDTLRASGIQTGGPDSLSQRDRQAFAAELEKWWLEVQRSRG
What are the official names of this protein?
UPF0178 protein YaiI.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: WOX10_ORYSJ
Sequence: MDRTATASWEVMSRRGEQQQQLMMQAPASHNGGSGGGEPARSRWAPKPEQILILESIFNSGMVNPAKDETARIRRLLERFGAVRDANVFYWFQNRRSRSRRRARQLQQACGAALHQLPSAAAAAGAGGGGDYYHHHHQPSSSPFLMHGGGGGGVVTSTTAAPAVAASGHFLADEVDGGGDDDLFAISRQMGLMARHGGGDHHYSSYADSDATQLSYQPTGTIQVFINGVAYDVPSGGALDMAGTFGRDAMLVHSSGEVLPVDEHGVLINSLQMGECYYLVSKSI
What is the function of this protein?
Transcription factor which may be involved in developmental processes.
What are the official names of this protein?
WUSCHEL-related homeobox 10, OsWOX10, Protein WOX11/12.
What is the protein family that this protein belongs to?
Belongs to the WUS homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MT3B_ORYSJ
Sequence: MSDKCGNCDCADKSQCVKKGTSYGVVIVDAEKSHFEMAEEVGYEENDGKCKCTTGCSCAGCNCGK
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-like protein 3B, Class I metallothionein-like protein 3B, OsMT-I-3b.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
Protein: WFD12_COLGU
Sequence: MGSSSFLVLMVSLALVTLVVVEGVKGGIEKAGVCPADNVRCFKSNPPQCHTDQDCLGERKCCYLHCGFKCVIPVKKLEEGGNKDEDVSGPHPEPGWEAKSPGSSSTGCPQI
What is the function of this protein?
Antibacterial protein.  Putative acid-stable proteinase inhibitor (By similarity).
What are the official names of this protein?
WAP four-disulfide core domain protein 12.
What are the subcellular locations of this protein?
Secreted.
Protein: CBOA_CONVX
Sequence: METLTLLWRASSSCLLVVLSHSLLRLLGVRCLEKSGAQPNKLFRPPCCQKGPSFARHSRCVYYTQSRE
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  The toxin with a disulfide connectivity C1-C2, C3-C4 (shown in the sequence annotation) block the rat nicotinic acetylcholine receptor (AChR) alpha-9-alpha-10/CHRNA9-CHRNA10 with an IC(50) of 1. 2 uM, whereas the one with C1-C3, C2-C4 shows a lower activity with an IC(50) of 3. 9 uM.
What are the official names of this protein?
Alpha-conotoxin VxXXIVA, AlphaB-conotoxin VxXXIVA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin B superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOC_STRA5
Sequence: MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPEREGLFDEVIFGPTKDWECACGKYKRIRYKGIICDRCGVEVTRAKVRRERMGHIELKAPVSHIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPMDTPLEPKSLLTEREYREKLQEYGYGSFVAKMGAEAIQDLLKRVDLDAEIAVLKEELKSATGQKRVKAVRRLDVLDAFKKSGNKPEWMVLNILPVIPPDLRPMVQLDGGRFAASDLNDLYRRVINRNNRLARLLELNAPGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLGKRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVARDLAGNVKAAKRMVERGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNADFDGDQMAIHVPLSEEAQAEARLLMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEDAGREGEGMIFKDHDEAVMAYQNGYVHLHTRVGIAVDSMPNKPWTEEQKHKIMVTTVGKILFNDIMPEDLPYLIEPNNANLTEKTPDKYFLEPGQDIQAVIDNLEINIPFKKKNLGNIIAETFKRFRTTETSAFLDRLKDLGYYHSTLAGLTVGIADIPVIDNKAEIIDAAHHRVEDINKAFRRGLMTEEDRYVAVTTTWREAKEALEKRLIETQDPKNPIVMMMDSGARGNISNFSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIIREDDCGTDRGLTITAITDGKEVTETLEERLIGRYTKKSIKHPETGEILVGADTLITEDMAAKVVKAGVEEVTIRSVFTCNTRHGVCRHCYGINLATGDAVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRIQEIFEARNPKGEAVITEVKGEVVAIEEDSSTRTKKVFVKGQTGEGEYVVPFTARMKVEVGDEVARGAALTEGSIQPKRLLEVRDTLSVETYLLAEVQKVYRSQGVEIGDKHVEVMVRQMLRKVRVMDPGDTDLLPGTLMDISDFTDANKDIVISGGIPATSRPVLMGITKASLETNSFLSAASFQETTRVLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNIEPLAVNEVEIIEGTPVDAEVTEVSTPTTED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: ATG12_PENRW
Sequence: MNTSSPTRSPQSSPSPNPQSTLSHRPSPRQPQSSDTPPNSSANAPIPDDEHGADLPMNMTASVMLTNLPRDAHQALADVESIDSGKVTVRFQPLPSAPILKNRVFKVSASQKFETVVKFLRKKLDCKDTDSVFCYVNSVFAPGLDEGMGGLWRCFKTDDQLIVAYSMTPAFG
What is the function of this protein?
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.  Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function.  The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Ubiquitin-like protein ATG12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: RS4_CAMJD
Sequence: MARYRGPVEKLERRFGVSLALKGERRLAGKSALDKRPYAPGQHGARKGKISEYGLQLREKQKAKFMYGVSEKQFRRLFAEAARREGNTGVLLIQLLEQRLDNVVYRMGFATTRRFARQLVTHGHVLVNGKRVDIPSFRVEAGAKIEIIEKSKNNPQITRAIELTAQTGIVAWVDVEKDKRFGIFTRKPEREEVVIPVEERFIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: TILS_RICAE
Sequence: MLYEKFEYNINNLIGNFGLSKISIAVSGGSDSVALLYLANIWAEKNNIELFVISVDHNLREQSKQETHYIQNISNSLNRKHYSLSFYHQNNFSNLQERAREGRYDLMTNLCLELDILVLLTAHHEDDYVENFCLRLERNSGIFGLSSSNINWYNNIQIIRPLYNIPKSKLVEYLVRHNIKWFEDESNSSDKYRRNVIRQKLAKGADYIRHFSKPVYREEFKGDTERSTAAYTLVREDASTGTASKLSLEAKCGKMSKAAIISQQLKTNKLIENEFKPELISAIAEAVKIFEYGFAFLDLVKFDKFSNEVKVQIINFLLIIISGQSRVARFYSVEPILKLITQDVNFKNTLHGCIIKRIQNELLIYREFGKKLPESKILLDKSVIWDNRFCITKNQETPNCFVTHLSLKDYKIIKKQLDLEPLKNLSCKNHNAVLLTLPIIKILEKVIAIPHISYYDNDMWNFEVSFSPNFVSRFTHFC
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSN17_MOUSE
Sequence: MPGKHQQFQDPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELAAGILAFVFKDWIRDQLNLFINNNVKAYRDDLDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDIRLKLELEQEGSIYTKGCVGQFEKWLQDNLIVVAGVLVGIALLQIFGLCLAQNLVSDIKAVKANW
What is the function of this protein?
Regulates ADAM10 maturation.
What are the official names of this protein?
Tetraspanin-17, Tspan-17, F-box only protein 23, Tetraspan protein SB134, Transmembrane 4 superfamily member 17.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.