PharMolix/UniProtQA huggingface dataset:
Protein: MRAY_SINMW
Sequence: MLIWLVELADHFQFFNLFRYITFRTGAALFTSALIVFLFGPAMIASLRIRQGKGQPIRADGPQTHFKKAGTPTMGGLMILAGIVVSSLLWADLSSIYVVSTLLVTLGFGAIGFYDDYLKVTKQSDKGFSGKARLGIEFVIASIAVFFMMQAALSAGAAGSTFGSSVTFPFFKDLMLNLGYFFVLFGGFVIVGAGNSVNLTDGLDGLAIVPVMIASAAFGLIAYLAGNAVFANYLQIHFVPGTGELAVILGAVIGAGLGFLWFNAPPAAIFMGDTGSLALGGLIGTVAVATKHEIVMVIIGGLFVMETLSVIIQVFWFKRTGHRVFLMAPIHHHFEKKGWTESQVVIRFWIIAVILAMVGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YBEY_SHEPA
Sequence: MSDSQMVIDLDVQVAVEGFELPSQAELELWVKTALRDTMSEAELTIRIVDVEESQELNMTYRGKDKPTNVLSFPFEAPPGIELPLLGDLVICAAVVEQEAIDQNKPLLAHWAHMVVHGCLHLLGYDHIEDVEAEEMESLETQLIESLGYINPYKEQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETG_PROM0
Sequence: MIEPLLCGIVLGLVPITLLGLFVSAWNQYRRGSGMLDID
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RL2_SALG2
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLVEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKAGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: BIOD_CAMJE
Sequence: MQIYVSGIHTDVGKTHFSAAFCANFNYDYFKLIQAGTPTDSEFIAKFSPKTKIFKEGIFLQTPASPHLGKIKEKLDYKALDIILPKSKNLLIELAGGLFSPMDENYTMIDFVNIFKHPTILVAKYYLGSINHILLSIEALKQRNINLLALVMMGKKDILQDDFIKNYAKIPIINLDFFDENSILNKDFKEQMQEILQLKIP
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMNMT_HORVV
Sequence: MDKISAPFFSGTSPAAASVAGVDEDDRLCFQAQELMFAYNISMVLRAAIQLGLLDALSAAGGKALTPNELVENVETSSNKAEAAAAVDRILRYLSCFNVVTCSSEAAGPDGTLVRRYTTGPLCRWLTKDRGDGTLSPFAVFVVDPDHLFPWHHIAEAVTAGGPSAFERTQKWPYYEYMGKNQRLGTLFDNAMAQHSVILVTKMLERFKGFDGVQRLVDVGGGTGSTLGMITSKYKHMTGINYDLPHVIAQGLPLPGVEHVAGDMYESIPTGDAVLLQWITLMLNDDEFVKILSNCHNALPKDGKVIVVDGILPENPDSSLTARDAFTLDIIMFVLFKGAKQRTEKEFARLAKQAGFTGGIKKTYIFFNFYALEFTK
What is the function of this protein?
Methylates 3-aminomethylindole (AMI) and N-methyl-3-aminomethylindole (MAMI), two substrates involved in gramine biosynthesis, a toxic indole alkaloid.  Can use S-adenosyl-L-methionine (AdoMet) as a methyl donor.  Unable to mediate caffeic acid O-methylation.
What are the official names of this protein?
3-aminomethylindole N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: LPXD_BRUA1
Sequence: MADPIFFKPSRELTIGDVADFTGASLRDPKLAPRSVERLASLKDAGEGALVFVEGKKNVSSLVGLKAAGVLCTESLADSVPSGIAVLVSRHPHRDFSAVGRMLFPASVRPESWLGETGISPAAFIHPTAQIEDGATVEAGAVIGSGVTIGAGTLIAATAVIGQNCQIGRNSYIAPGVSVQCAFIGNNVSLHPGVRIGQDGFGYVPGAAGLDKVPQLGRVIIQDNVEIGANTTVDRGSLDDTVIGEGTKIDNLVQIAHNVRIGRFCLVAAHCGISGSCVIGDQTMLGGRVGLADHLIIGSRVQVAAASGVMNDIPDGERWGGIPARPIKQWFRDIANIRSIGQSRKDASSDE
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: SYY_SALPA
Sequence: MASSNLIKQLQERGLVAQVTDEDALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVAKIRKQVAPFLDFDCGENSAIAANNYDWFGSMNVLTFLRDIGKHFSVNQMINKEAVKQRLNRDDQGISFTEFSYNLLQGYDFACLNKLHGVALQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMDIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLVAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDAELQPSRGQARKTIASNAVTINGEKQSDPEYIFNDEDRLFGRYTLLRRGKKNYCLICWK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CM3G_CONRE
Sequence: CCMALCSRYHCLPCC
What are the official names of this protein?
Conotoxin reg3g.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPA_CYTH3
Sequence: MIELPVVPSASDRKSKPDWLRVKLPIGKEYTKLRALVDEHKLHTICQSGNCPNMGECWGAGTATFMILGNVCTRSCSFCAVATGRPTEYDIDEPKRVAEAVRLMNVKHCVITSVNRDELKDKGAEVWYQTVVRVKEESPQTTIETLIPDVKSDWASLERMISGGQEVVSHNMETVERLYRRVRPQAKYSRSLEEIQRIKAFGKRTKSGIMLGLGETKDEVLKAMDDLVAHGLDVLTLGQYLQPTKMHLEVAEFIHPDQFAEYKEIGLSKGLNYVESGPLVRSSYHAEKHI
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O11H6_HUMAN
Sequence: MFFIIHSLVTSVFLTALGPQNRTMHFVTEFVLLGFHGQREMQSCFFSFILVLYLLTLLGNGAIVCAVKLDRRLHTPMYILLGNFAFLEIWYISSTVPNMLVNILSEIKTISFSGCFLQFYFFFSLGTTECFFLSVMAYDRYLAICRPLHYPSIMTGKFCIILVCVCWVGGFLCYPVPIVLISQLPFCGPNIIDHLVCDPGPLFALACISAPSTELICYTFNSMIIFGPFLSILGSYTLVIRAVLCIPSGAGRTKAFSTCGSHLMVVSLFYGTLMVMYVSPTSGNPAGMQKIITLVYTAMTPFLNPLIYSLRNKDMKDALKRVLGLTVSQN
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 11H6, Olfactory receptor OR14-35.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HTRM_HALMA
Sequence: MSAVTKRSGSYGRTLGVGAVLVLVLATLAVVNVYTNLAPEMSGSQQSMLLSGLVSILLIVAVALLFVATIIGRERTAAVETLAAQARQIEQGELDVDLATNRTDDVGDIYRALAVLRDSEQLDRQHGVSAEVVAQYCETAVEISNGNDDSRLEENVDDPQLAELAMRFNEILDQRKRDAEIDSR
What is the function of this protein?
The HtrM-Xop2/SRM complex may interact with CheB or CheR and modulate their availability to Sop1 or Sop2.
What are the official names of this protein?
Probable sensory rhodopsin transducer, HmHtrM.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL11_META3
Sequence: MATEVVDVLVTGGKATAGPPLGPAVGPLGINIMNVVKEINEKTKDYAGMSVPVKVIVNTDDRSFEIEVGIPPTSALIKTELGLDKGSTEPKAIVAGNLSMEQAVKIAKMKKDSMLSFTLKNATKEVIGTCVSTGINVEGMSPRDAQKAIDAGEFDEYFNE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CATW_FELCA
Sequence: MAITVYLSCLLVLSMAGLAQGIKSSLRSQDPGPQPLELKQAFTLFQIQYNRSYSNPEEYARRLDIFAHNLAQAQQLEEEDLGTAEFGVTPFSDLTEEEFGRLYGHRRMDGEAPKVGREVGSEEWGESVPPTCDWRKLDGVISSVKKQESCSCCWAMAAAGNIEALWAIKYRQSVELSVQELLDCGRCGDGCRGGFVWDAFITVLNNSGLASEKDYPFQGQVKPHRCLAKKRTKVAWIQDFIMLPDNEQKIAWYLATQGPITVTINMKLLKLYKKGVIEATPTSCDPFLVDHSVLLVGFGKSESVADRRAGAAGAQPQSRRSIPFWILKNSWGTKWGXGGYFRLYRGNNTCGITKYPLTARVDQPAKKRPVSCPP
What is the function of this protein?
May have a specific function in the mechanism or regulation of T-cell cytolytic activity.
What are the official names of this protein?
Cathepsin W.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: HRP1_PLAFA
Sequence: MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
What are the official names of this protein?
Histidine-rich protein PFHRP-II.
Protein: F221A_XENLA
Sequence: MEKLQFQGGDRAVDEYAEYRRIVGDDDGGKLFTPEEYEQYKKTVLPMRLQNRLYVSWRSPCGMDCKLVGPETACFCTHRYKQHKTDFKELPKERPVLLPCKVSKCPCKSFHYIPLNGSRPIRCRCKHFADEHSLAGTYHCTKCTKCSGFHSSFTCGCGQPAYAHDTIVETKEERLAQGKPVGHDVPYASMGGLTGFSSLAEGYMRLDASGTGAPGASFLESSQSGASHPFLKMYDMPCTVQGVSEPPGIDKQVSSMRLSEEDDMAYFERRYQERLRKEKEHKRQKNSKPPTTQRP
What are the official names of this protein?
Protein FAM221A.
What is the protein family that this protein belongs to?
Belongs to the FAM221 family.
Protein: RSSA_BLAGS
Sequence: MAPSNLPPIFNATSQDIEMLLAAQCHLGSKNLQVHMDPYLWKTRPDGINVINIGKTWEKIVLAARIIAAIDNPADVCVISARPYGQRAVLKFAAHTGAAAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDHQAIKEASYVNIPVIALCDTDSPTEFVDVAIPTNNKGRHAIGLIWWMLAREVLRLRGTIASRETEWDVVVDLYFYRDPEAEENKEIEEAKVPGAEEVGAAAIESGLVGDSWEAQVAPAFAATGAAVPAGAAPGWEAEAAGEWAASSGAAAGAAETWATDTAAPDAGVKW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WZZB3_ECOLX
Sequence: MRVENNNVSGQNHDPEQIDLIDLLVQLWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIITQPDVGQIAGYNNAMNVIYGQAAPKVSDLQETLIGRFSSAFSALAETLDNQEEPEKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKLAQYIQQVDDKVNQELEKDLKDNIALGRKNLQDSLRTQEVVAQEQKDLRIRQIQEALQYANQAQVTKPQIQQTQDVTQDTMFLLGSEALESMIKHEATRPLVFSSNYYQTRQNLLDIDNLDVDKLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNYNAK
What is the function of this protein?
Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS).  Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111/M92) and of 17 (in strain K12).
What are the official names of this protein?
Chain length determinant protein, Polysaccharide antigen chain regulator.
What is the protein family that this protein belongs to?
Belongs to the WzzB/Cld/Rol family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SDHF2_YEAS7
Sequence: MHNMFPALTKTLSLQGYKIINSQTGSAAWSCGRRWFSSDKDDHDDVVTRIKISPIKRTNEPLDKKRARLIYQSRKRGILETDLLLSGFAAKYLKKMNEEELEEYDSLLNELDWDIYYWATKNFKTSPLPDKWANSKLLKQLQEFSENKEKEILSMPDLSKYQ
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 2, mitochondrial, SDH assembly factor 2, SDHAF2.
What is the protein family that this protein belongs to?
Belongs to the SDHAF2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SYCE2_HUMAN
Sequence: MERQGVDVPHVKCKDQEPQPLGESKEHPRWEENCEEEAGGGPASASCQLTVLEGKSGLYFSSLDSSIDILQKRAQELIENINKSRQKDHALMTNFRNSLKTKVSDLTEKLEERIYQIYNDHNKIIQEKLQEFTQKMAKISHLETELKQVCHSVETVYKDLCLQPEQSLRLRWGPDHSRGKSPPRPGNSQPPDVFVSSVAETTSQATASEVQTNRDGEC
What is the function of this protein?
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase.  Requires SYCP1 in order to be incorporated into the central element.  May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).
What are the official names of this protein?
Synaptonemal complex central element protein 2, Central element synaptonemal complex protein 1.
What is the protein family that this protein belongs to?
Belongs to the SYCE family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE1 in the central elements (By similarity).
Protein: MURB1_BACC1
Sequence: MEQLVNELIEANVGRVLVDEPLARYTTMKIGGPADILIVPKHVAGIEKTLQLVKKYKTKWTVIGRGSNLLVSDLGIEGVVIRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGLEFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGTIDWLTHEEMEFSYRTSVLQTKRPGIVLEAEFQLQIGEREGIVSVMQKNKDYRRETQPWNHPCAGSVFRNPIPYFAGDLIEKAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALVKQTIKDKFSVEMHTEVEIIGR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase 1, UDP-N-acetylmuramate dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MD2L1_HUMAN
Sequence: MALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
What is the function of this protein?
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:29162720, PubMed:15024386).  In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720).  Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386).
What are the official names of this protein?
Mitotic spindle assembly checkpoint protein MAD2A, HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the MAD2 family.
Protein: RSEP_SALT1
Sequence: MLSILWNLAAFIIALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDRYGTEYVIALIPLGGYVKMLDERAEPVAPELRRHAFNNKTVGQRAAIIAAGPVANFIFAIFAYWLVFIIGVPGVRPVIGEITPNSIAAQAQIAPGTELKAVDGIETPDWDAVRLQLVSKIGDQQTTVSVAPFGSDQRQDKTLDLRHWAFEPDKQDPVSSLGIRPRGPQIEPVLSEVQANSAASKAGLQAGDRIVKVDGQPLTQWMKFVTFVRDNPGKPLALEIERQGSALSLTLTPDTKSVNGKAEGFAGVVPKIIPLPEEYKTIRQYGPFSAILEATDKTWQLMKLTVSMLGKLITGDVKLNNLSGPISIAQGAGMSAEFGVIYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKLKGGPVSERVQDFSYRIGSILLVLLMGLALFNDFSRL
What is the function of this protein?
A site-2 regulated intramembrane protease that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA.  Part of a regulated intramembrane proteolysis (RIP) cascade.  Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA.  This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA.
What are the official names of this protein?
Regulator of sigma-E protease RseP, S2P endopeptidase, Site-2 protease RseP, S2P protease RseP, Site-2-type intramembrane protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLND_ECO5E
Sequence: MNTLPEQYANTALPTLPGQPQNPCVWPRDELTVGGIKAHIDTFQRWLGDAFDNGISAEQLIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECMLEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPIDDEFQLRGTLIDLRDETLFMRQPEAILRMFYTMVRNSAITGIYSTTLRQLRHARRHLQQPLCNIPQARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVNVWPRLPSTELIFIAALFHDIAKGRGGDHSILGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEVLHQIWSRCRANYFVRHSPNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLSADRHEVIRFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLELIALDQPGLLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: RLMN_MYCSJ
Sequence: MPNPLPLVFDAPRRAKPPRHFADLDATARAAAVAELGLPAFRAKQLATQYYGRLTADPQQMTDLPAAVREQVAEALFPDLLTAVREIETDAGETRKVLWRAVDGTTFESVLMRYSDRNTVCISSQAGCGMACPFCATGQGGLQRNLSTAEILEQVRAAAVELRDRDGEGIAPAARGGRLSNIVFMGMGEPLANYNRVIAAVRRIVAPPPDGFGISARSVTVSTVGLAPAIRKLADERLNVTLALSLHAPDDELRDTLVPVNNRWKVSEALDAARYYADVTGRRVSIEYALIRDVNDQPWRADLLGKRLHGALGPLVHVNVIPLNPTPGSEWDASPKPAEREFVRRVRERGVSCTVRDTRGREIAAACGQLAAEG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG12_YEAS7
Sequence: MSRILESENETESDESSIISTNNGTAMERSRNNQELRSSPHTVQNRLELFSRRLSQLGLASDISVDQQVEDSSSGTYEQEETIKTNAQTSKQKSHKDEKNIQKIQIKFQPIGSIGQLKPSVCKISMSQSFAMVILFLKRRLKMDHVYCYINNSFAPSPQQNIGELWMQFKTNDELIVSYCASVAFG
What is the function of this protein?
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.  Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function.  The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.  ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity (By similarity).
What are the official names of this protein?
Ubiquitin-like protein ATG12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Localizes to the isolation membrane (IM), a membrane sac which is generated from the pre-autophagosomal structure (PAS) (By similarity). Ultimately, the IM expands to become a mature autophagosome. Localizes also to a dot at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS) (By similarity).
Protein: Y1481_ARCFU
Sequence: MKTISIRDDVYRKLLEMKDEEDSFSDVIEKLLKRKKTDIRRYFGVLKDSEVLDEIEKSLNARKSARFRV
What is the function of this protein?
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Putative antitoxin AF_1481.
What is the protein family that this protein belongs to?
Belongs to the UPF0330 family.
Protein: SCX5_CENEX
Sequence: AKDGYLVSKSTGCKYECFWLGKNEGCDKECKAPNQGGGYGYCHAFACWCENLPESTPTYPIPGKSCGKK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Neurotoxin Cex5.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.