PharMolix/UniProtQA huggingface dataset:
Protein: LPXB_CHRSD
Sequence: MRIYLVAGELSGDILGAGLMQALKRRHPDAEFRGIGGPRMLAEGMQSLYPLETLSVMGLVEVLKHLPGLIKVRRHLRRDALAWQPDVMIGIDAPDFNLGLERQLRATGMRTVHYVSPSVWAWRQGRVKTIARSVDAMLTFLPFEAAFYARHQVPVAFVGHPLADELPLVNDRQAARTALGLSSTAPLLAVLPGSRGNEIRFLGPTFLDSAVWLRERVPGLQVVIPAASPARRQELEVLLATHPAREFVHLRDGESRQAMTAADAVLLASGTAALEAMLCHRPMVVAYKMAAATHWLAKRMVKTEWISLPNLIAQETLVPELVQEDASCEAIGEALLTWLGDETHRQATETRFAALHATLQRGASERAAEAIDSLVVHGRLPEEPTA
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: ATPB_ATRBE
Sequence: MRINPTTSGSGVSTLEKKNLGRVVQIIGPVLDVAFPPGKMPNIYNALVVQGRDSVGQPINVACEVQQLLGNNRVRAVAMSATDGLTRGMEVIDKGAPISVPVGGATLGRIFNVLGEPVDNLGPVDTSTMSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEENIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDIIAILGLDELSEEDRLLVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAMNLEMESNLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: MNME_PSE14
Sequence: MNVPRETIAAIATAQGRGGVGIVRVSGPLAGRAAEAIIGRTLKPRFAHYGPFVDDAGQVLDEGIALYFPGPNSFTGEDVLELQGHGGPIVLDMLLQRCLQLGSRLARPGEFSERAFLNDKLDLAQAEAIADLIEASSAQAARNALRSLQGAFSRRVDNLTEKLISLRIYVEAAIDFPEEEIDFLADGHVLNMLDDVRAELSTVLREAGQGALLRDGMTVVIAGRPNAGKSSLLNALAGREAAIVTEIAGTTRDVLREHIHIDGMPLHVVDTAGLRDTQDQVEMIGVQRALKAIGEADRILLVVDATAPEAADPFALWPEFLEQRPDPAKVTLIRNKADLSGDPIDLQTSVDGHVTISLSARSGGAGLELLREHLKACMGYEQTSESSFSARRRHLEALRHASDSLEHGRAQLTLAGAGELLAEDLRQAQQALGEITGAFSSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_CUTAK
Sequence: MTTAVGASQQLDEVGDRRGTGTEFANEIFAVVDVLNRESGLRRAVSDTGSETKARQGLIDAVFTSKVSPDCKELLDATTTCKWRSPAALTRALERQGVRAVLRGARQADRFEAVADELFHVSRLVRGQAALQVALGDPNRSVADRQELLMKLVGGQVSEETLVLARRAVVASDSTFEQVIDGYLHVAAEMADRRRAIVTTAKALTDAQRAEMVKQLERITGSPIELSEVVDPTVLGGALINLGDEVIDSTVAHRLDQARRELG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL27_RHOP5
Sequence: MAHKKAGGSSRNGRDSAGKRLGIKTYGGEHVIPGNIIARQRGTTWHPGLNVGMGTDHTLFAKIEGHVQFRAKGNGRTFVSVLPIVAAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: FOXQ1_MOUSE
Sequence: MKLEVFVPRAAHGDKMGSDLEGAGSSDVPSPLSAAGDDSLGSDGDCAANSPAAGSGAGDLEGGGGERNSSGGPSAQDGPEATDDSRTQASAAGPCAGGVGGGEGARSKPYTRRPKPPYSYIALIAMAIRDSAGGRLTLAEINEYLMGKFPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRRRKRLSHRTTVSASGLRPEEAPPGPAGTPQPAPAARSSPIARSPARQEERSSPASKFSSSFAIDSILSKPFRSRRDGDSALGVQLPWGAAPCPPLRAYPALLPAAPGGALLPLCAYGASEPTLLASRGTEVQPAAPLLLAPLSTAAPAKPFRGPETAGAAHLYCPLRLPTALQAAAACGPGPHLSYPVETLLA
What is the function of this protein?
Plays a role in hair follicle differentiation.
What are the official names of this protein?
Forkhead box protein Q1, HFH-1l, HNF-3/forkhead-like protein 1, HFH-1, Hepatocyte nuclear factor 3 forkhead homolog 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: SRAP_STAAU
Sequence: MSKRQKAFHDSLANEKTRVRLYKSGKNWVKSGIKEIEMFKIMGLPFISHRIVSQDNQSISKKMTGYGLKTTAVIGGAFTVNMLHDQQAFAASDAPLTSELNTQSETVGNQNSTTIEASTSTADSTSVTKNSSSVQTSNSDTVSSEKSENVTSTTNSTSNQQEKLTSTSESTSSKNTTSSSDTKSVASTSSTEQPINTSTNQSTASNNTSQSTTPSSANLNKTSTTSTSTAPVKLRTFSRLAMSTFASAATTTAVTANTITVNKDNLKQYMTASGNATYDQSTGIVTLTQDAYSQKGAITLGTRIDSNKSFHFSGKVNLGNKYEGHGNGGDGIGFAFSPGVLGETGLNGAAVGIGGLSNAFGFKLDTYHNTSTPNASAKAKADPSSVAGGGAFGAFVTTDSYGVASTYTSSSAADNAAKLNVQPTNNAFQDFDINYNGDTKVMTVTYAGQTWTRNISDWIAKSGTTNFSLSMTASTGGATNLQQVQFGTFEYTESAVTQVRYVDVTTGKDIIPPKTYSGNVDQVVTIDNQQSALTAKGYNYTSVDSSYASTYNDTNKTVKMTNAGQSVTYYFTDVKAPTVTVGNQTIEVGKTMNPIVLTTTDNGTGTVTNTVTGLPSGLSYDSATNSIIGTPTKIGQSTVTVVSTDQANNKSTTTFTINVVDTTAPTVTPIGDQSSEVYSPISPIKIATQDNSGNAVTNKSTGLPSGLTFDSTNNTISGTPTNIGTSTITIVSTDASGNKTTTTFKYEVTRNSMSDSVSTSGSTQQSQSVSTSKADSQSASTSTSGSIVVSTSASTSKSTSVSLSDSVSASKSLSTSESNSVSSSTSTSLVNSQSVSSSMSDSASKSTSLSDSISNSSSTEKSESLSTSTSDSLRTSTSLSDSLSMSTSGSLSKSQSLSTSTSDSASTSQSVSDSTSNSISTAESLSESASTSDSISISNSIANSQSASTSKSDSQSTSISLSTSDSKSMSTSESLSDSTSTSDSVSGSLSVAGSQSVSTSTSDSMSTSEIVSDSISTSGSLSASDSKSMSVSSSMSTSQSGSTSESLSDSQSTSDSDSKSLSLSTSQSGSTSTSTSTSSSVRTSESQSTSGSMSTSQSDSTSISTSFSDPTSDSKSASTASSESISQSVSTSTSGSVSTSTSLSTSNSERTSTSMSDSTSLSTSESDSTSDSTSTSDSISEAISGSESTSISLSESNSTGDSESKSASAFLSESLSESTSESTSESLSGSTSDSTSLSDSNSESGSTSTSLSNSTSGSTSISTSTSGSASTSTVKSESVSTSLSTSTSTSLSDSTSLSTSLSDSTSGSKSNSLSASMSTSDSISTRKSESLSASTSLSGSTSESESGSTSSSASQSDSTSMSLSMSQSISGSTSTSTSTSLSDSTSTSLSLSASMNQSGVDSNSASQSASTSTSISTSESDSQSTSTYTSQSTSQSESTSTSTSISDSTSISKSTSQSGSTSTSASLSGSESESDSQSVSTSASESTSESASTSLSDSTSTSNSTSESTSNAISTSASASESDSSSTSLSDSTSASMQSSESDSQSTSTSLSNSQSTSTSIRMSTIVSESVSESTSESGSTSESTSESDSTSTSLSDSQSTSRSTSASGSASTSTSTSDSRSTSAPTSTSMRTSTLDSQSMSLSTSTSTSVSDSTSLSDSVSDSTSDSTSTSTSGSMSASISLSDSTSTSTSASEVMSASISDSQSMSESVNDSESVSESNSESDSKSMSGSTSVSDSGSLSVSTSLRKSESVSESSSLSGSQSMSDSVSTSDSSSLSVSMSLRSSESVSESDSLSDSKSTSGSTSTSTSGSLSTSLSGSESVSESTSLSDSISMSDSTSTSDSDSLSGSISLSGSTSLSTSDSLSDSKSLSSSQSMSGSESTSTSVSDSQSSSASNSQFDSMSISASESDSVSTSDSSSISGSNSTSTSLSTSDSMSGSVSVSTSTSLSDSISGSISVSDSSSTSTSESLSDSMAQSQSTSTSASGSLSTSISTSMSMSASTSTSQSTSVSTSLSTSDSISDSTSISISGSQSAVESESTSDSTSISDSESLSTSDSDSTSTSTSVSTSGSTSTSVSESLSTSGSGSTSVSDSTSMSESDSTSASMSQDKSDSTSISNSESVSTSTSTSLSTSDSTSTSESLSTSMSGSQSISDSTSTSMSNSTSMSNSTSTSMSGSTSTSESNSMHPSDSMSMHHTHSTSTSISTSEATTSTSDSQSTLSATSEATKHNGTRAQSEERLPDTGESIKQNGLLGGIMTLLVGLGLMKRKKKKDENDQDDSQA
What is the function of this protein?
Mediates binding to human platelets, possibly through a receptor-ligand interaction.  Probably associated with virulence in endovascular infection (By similarity).
What are the official names of this protein?
Serine-rich adhesin for platelets, Adhesin SraP, Staphylococcus aureus surface protein A.
What is the protein family that this protein belongs to?
Belongs to the serine-rich repeat protein (SRRP) family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Exported by the accessory SecA2/SecY2 system. Anchored to the cell wall by sortase A (By similarity).
Protein: ISPE_SPHAL
Sequence: MSATMRETGWAKINLALHVRARRADGYHDIETLFAFVDGGDTIEAALAATDTLVIDGEFAEGLSSGADNLVLRVLALLRARYGADRVPPLAVRLTKRLPLAAGIGGGSADAAAMARLVRTHFLPELGDATLARIVGPLGADIAACVASTTCMGSGTGEDLHAVAGLRIAGVPVLLVNPRQPVATGPVFAAWDGIDRGPLYIGTDYRAQLIGARNDLQRPALAACPAISDILLELGALRPWLARMSGSGATCFALFDAAADRDAAKAVLAARHPGWWLMAGALR
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: MHPB_COMTE
Sequence: MSGSAIATARRAFLGMSHSPLLGLNPVAADDQIAIDKAIAAARAAVHEFAPELIVLLGPDHYNGFFNELMPPFCIGSQATAVGDYLSPAGPLNVAGELAIALADHLMDRHFDIAVSRRMLVDHGFSQALQFLWGDEMDTPPVIPIFMNAVAQPGIARMARCKALGEGVGSFLDQLPLRTLLIGSGGLSHEPPVPTLAHPDPAVRERITVRSTPTEQERELKTERVKAAGLALAHGDSWMKPLNPEWDLQWMDAMASGQLDGLCAMNEASIGAMAGNSAHESKTWLVARSALPANTRLSCPVRAYRAIPSLIAGYGVMFMHH
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: 3SOE_HEMHA
Sequence: LICHNRPLPFLHKTCPEGQNICYKMTLKKTPMKLSVKRGCAATCPSERPLVQVECCKTDKCNW
What is the function of this protein?
This toxin has a very low toxicity.
What are the official names of this protein?
Cytotoxin homolog, Toxin 9B/9BB.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group XIV sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FOS_BOVIN
Sequence: MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDYCTDLAVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGVPTPSAGAYSRAGVMKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLSGGLPEAATPESEEAFTLPLLNDPEPKPSVEPVKSVGSMELKAEPFDDYMFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHGGSLGMGPMATELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL
What is the function of this protein?
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.  On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling.  Has a critical function in regulating the development of cells destined to form and maintain the skeleton.  It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity).  In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A.  This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
What are the official names of this protein?
Protein c-Fos, Cellular oncogene fos, Transcription factor AP-1 subunit c-Fos.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Fos subfamily.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity).
Protein: CUTC_ALISL
Sequence: MPIQIEVCIDNLESLHNAINGGADRIELCSSLALGGLTPSFGFMKKAAAISSVPVYAMIRPRQGDFLYDNDDISAMIEDIHAAKLAGLQGVVFGVLKANGDIDMPLSTRLMKIANDNDLGVTFHRAVDQCSNYKKAIENIAELGCERILTSGLAANAYDGMTVLNDMVKLANGRFKILAGAGVTAENAKEIIEKTGVTEIHLSGKSTRPSKMKLMLDGVKMGAGDLDDFIVPVTDSKKIDAVRQNIK
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTAS_STAAB
Sequence: MSSQKKKISLFAFFLLTVITITLKTYFSYYVDFSLGVKGLVQNLILLMNPYSLVALVLSVFLFFKGKKAFWFMFIGGFLLTFLLYANVVYFRFFSDFLTFSTLNQVGNVESMGGAVSASFKWYDFVYFIDTLVYLFILIFKTKWLDTKAFSKKFVPVVMAASVALFFLNLAFAETDRPELLTRTFDHKYLVKYLGPYNFTVYDGVKTIENNQQKALASEDDLTKVLNYTKQRQTEPNPEYYGVAKKKNIIKIHLESFQTFLINKKVNGKEVTPFLNKLSSGKQQFTYFPNFFHQTGQGKTSDSEFTMDNSLYGLPQGSAFSLKGDNTYQSLPAILDQKQGYKSDVMHGDYKTFWNRDQVYKHFGIDKFYDATYYDMSDKNVVNLGLKDKIFFKDSANYQAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDEALEEYINDLKKKGLYDNSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFTDLNRTGFWIKIPGKSGGINNEYAGQVDVMPTILHLAGIDTKNYLMFGTDLFSKGHNQVVPFRNGDFITKDYKYVNGKIYSNKNNELITTQPADFEKNKKQVEKDLEMSDNVLNGDLFRFYKNPDFKKVNPSKYKYETGPKANSKK
What is the function of this protein?
Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate.  Is required for staphylococcal growth and cell division process (By similarity).
What are the official names of this protein?
Lipoteichoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the LTA synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Processed glycerol phosphate lipoteichoic acid synthase]: Secreted.
Protein: M3B_CONTE
Sequence: MSKLGALLTICLLLFSLTAVPLDGDQHADQPAQRLQDRIPTEDHPLFDPNKRCCPPVACNMGCKPCCG
What is the function of this protein?
Intracranial injection into mice causes scratching, hyperactivity and circular motion.
What are the official names of this protein?
Conotoxin tx3b, Tx3.3.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL7_NEIPE
Sequence: MAITKEDILEAVGSLTVMELNDLVKAFEEKFGVSAAAVAVAGPAGAGAAAAEEKTEFDVVLASAGDQKVGVIKVVRAITGLGLKEAKDIVDGAPKTLKEGVSKAEAEDIQKQLEEAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: Y2550_BRUO2
Sequence: MRSSIHASRLRKMGQSIPASTGPMARSANRFLQNRAAIFGLVLLTPLLFAVLTYPLWLPYKPNDIDLMAMNSAPSWKHWFGADGVGRDVFARTMEGGRISLLVAVSSVVLSTAIGFLIGAISALGGRWADAIAMRSVDLAMTLPPVIFLLVLASIIGSGIWSTVVVIALLSWPVLSRMIRARLLELREREFVMASRGMGAGLGHLLFRHGLPNSIDILVVYATLQVANAILLEAGLSFLGLGVPPPAASWGNMLNAARSTAVLEQFPWQWLFPGGALVLAVLAINFIGDGLRDAFDPRAELN
What is the function of this protein?
Probably part of an ABC transporter complex that could be involved in peptide import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Putative peptide permease protein BOV_A0350.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LMBL3_MOUSE
Sequence: MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDESEMESVKKATATTTWMVPTAQDAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGVPFRLKEQSKADGLQFCENCCQYGNGDECLSGGKYCSQNCARHAKDKDQKDERDGGEDNDEEDPKCSRKKKPKLSLKADSKDDGEERDDEMENKQDGRILRGSQRARRKRRGDSAVLKQGLPPKGKKTWCWASYLEEEKAVAVPTKLFKEHQSFPYNKNGFKVGMKLEGVDPDHQAMYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLRPPKGYKEEEFNWQSYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAADKKSPSVICVATVTDMVDNRFLVHFDNWDESYDYWCESNSPHIHPVGWCKEHRRTLITPPGYSHVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEAVDKRNPLFIRVATVADTDDHRIKVHFDGWSSCYDYWIDADSPDIHPVGWCSKTGHPLQAPLSPAELMEPSETGGCPTLGCRGVGHFKKSRYLGTQSGANCPYSEINLSKERIFPDRLSGDTSPPTTPSFPRSKRMDTRESSSSPETREKHANNFKEDSEKKKENEVKTSAEAKVVREEPTPSVQQSQPPQQVQQVQHAQPPQQAQKAPQAQQAQQAQQAQQAPQAPQTPQPQQAPQVQQAQQAPQAQQAQQPQQAQQPQQAPPVQQPQQVQQAQPTQQQAQTQQQAQRRSAVFLSFKPPIPCLPLRWEQQSKLLPTVAGIPASRVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
What is the function of this protein?
Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression.  It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (By similarity).  Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2.  It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:30442713).  Also involved in the regulation of ubiquitin-dependent degradation of methylated DNMT1 and E2F1 (By similarity).  Required for normal maturation of myeloid progenitor cells.
What are the official names of this protein?
Lethal(3)malignant brain tumor-like protein 3, L(3)mbt-like protein 3, MBT-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y3939_KLEP7
Sequence: MDGMENLMPREKMLQYGIETLTDVELLALFLRVGTRRQDVLSYAQALLQRFGSLYALLSADKAQLIAVDGLGLAKYAQLKGIAELARRYFSSQLVEEAALVTPSMTREFLQSQLTEEEREIFMVIFLDNQNRVLKHSRLFSGTLSHVEVHPREIVREAIKVNAAAVILAHNHPSGSPEPSQADRLITERVIKCCRFMEIRVLDHLVIGRGAYVSFAERGWI
What are the official names of this protein?
UPF0758 protein KPN78578_39390.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family. YicR subfamily.
Protein: BLA2_KLEPO
Sequence: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
What is the function of this protein?
This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
What are the official names of this protein?
Beta-lactamase SHV-2, SHV-2A.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: DCD_BURM1
Sequence: MSIKSDKWIRRMAEEHKMIEPFVPDQVRASEDGRRIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEGSFVDFKGDVCIIPPNSFALARTVEYFRIPRTVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVLFFESDEVCDVSYADRGGKYQGQRGVTLPKT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: MYH10_MOUSE
Sequence: MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVDRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGIKFAKDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDVEALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHIEGASLELSDDDTESKTSDVNDTQPPQSE
What is the function of this protein?
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.  During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity).  Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
What are the official names of this protein?
Myosin-10, Cellular myosin heavy chain, type B, Myosin heavy chain 10, Myosin heavy chain, non-muscle IIb, Non-muscle myosin heavy chain B, NMMHC-B, Non-muscle myosin heavy chain IIb, NMMHC II-b, NMMHC-IIB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells.
Protein: DDL_RHIME
Sequence: MSSKHVAVLLGGFSSERPVSLSSGTACADALEAEGYRVTRVDVGRDVAAVLQELRPDVVFNALHGPFGEDGTIQGILEYLEIPYTHSGVLASALAMDKDQAKHVAKAAGIPVAEALVMDRRSFGNQHPMKPPYVVKPVREGSSFGVVIVKEDQSHPPQVITSSEWRYGDRVMVERYIAGREFTCGVMGDVALGVTEIIPQGHAFYDYDSKYVKGGSKHVIPAQISPNIYQKIQTLALKAHQAIGCRGVSRSDFRFDDRGDGEGELIWLEINTQPGMTPTSLVPEMAQHAGLQFGEFLRWMVEDASCLR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOS3_CAVPO
Sequence: WYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATVSFMKHLENEQKGRGGCPADWGWDPCPPSRA
What is the function of this protein?
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway.  NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).
What are the official names of this protein?
Nitric oxide synthase, endothelial, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII.
What is the protein family that this protein belongs to?
Belongs to the NOS family.
What are the subcellular locations of this protein?
Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Cell membrane. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.