PharMolix/UniProtQA huggingface dataset:
Protein: SPEA_HALH5
Sequence: MSRQEQTPLFSGVVAHAKHNPVQFHIPGHKKGAGMDPAFRSFIGDNALSIDLINIGPLDDLHHPHGIIKEAQELAAEAFGADHTFFSVQGTSGAIMTMIMSVVGPGEKIIVPRNVHKSIMSAIVFSGATPVFIHPEIDPLLGISHGITIEAVEKALDAHPDAKGLLVINPTYFGIAANLKKIVELCHSRDVPVLVDEAHGVHIHFHEALPLSAMQAGADMAATSVHKLGGSLTQSSILNVREGLVSAKRVQTIISMLTTTSTSYLLLASLDAARKHLATNGRDLIGYTIQLADQARDQINAIDGLYCVGKEILGTIATYDYDPTKLIISVKNLGITGYDAEVWLREHYQIEVELSDLYNILCIVSFGDTEREMDLLVKALSELADLHKHGICERSPVSVYVPNIPTLAMSPRDAFYAETEVVPFEDSVGRTIAEFIMVYPPGIPILIPGEIITESNLAYIRENNRAGLPVQGPEDDTFRTLRVIKEHEAIR
What is the function of this protein?
Catalyzes the formation of agmatine from arginine.
What are the official names of this protein?
Arginine decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-I family.
Protein: ARGJ_BURMA
Sequence: MAVNFPSIDPAQLHPVAGVTLGWAEANIRKPNRKDVLVVSVEEGATVSGVFTENRFCAAPVTVCREHLAKVRAGGAGIRALVVNTGNANAGTGEPGLAHARETCAELARLAGIAPGQVLPFSTGVILEPLPIERLKAGLPAALANRAAANWHDAAQAIMTTDTLPKAASRQVMIDGHTITLTGISKGAGMIKPNMATMLGFLAFDAKVAQPVLDALVKDVADRSFNCITIDGDTSTNDSFILIASGKASLPQIASTDSPAYAALREAVTSVAQALAQLIVRDGEGATKFITVTVEGGKSAAECRQIAYAIGHSPLVKTAFYASDPNLGRILAAIGYAGVADLDVGKIDLYLDDVLVAKAGGRNPAYLEEDGQRVMKQSEIAVRVLLGRGDAQATIWTCDLSHDYVSINADYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLF4_SHEEP
Sequence: XSSLPAASVSLPADSEGGEEEDLQCVCLKTTSGIHPRHISSLEVIGAGLHCPSPQLIATLKTGRKICLDQQNPLYKKIIKRLLKN
What is the function of this protein?
Released during platelet aggregation.  Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule.  Chemotactic for neutrophils and monocytes.  Inhibits endothelial cell proliferation.
What are the official names of this protein?
Platelet factor 4, PF-4, C-X-C motif chemokine 4.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: COBS_SHEHH
Sequence: MQLWQKQLNLFFIAMGFFTRIPMPKWIEVDADKLNKASRYFGLVGLLVGAISAAVYSLMLYWVSPSVAIVFAMITSVLVTGGFHEDGLADTADGLGGGWTVEAKLNIMKDSRLGSYGALALVLALLLKWQLLTELALFDPSSVSLALIVGHCLSRVVAASFIFSEEYVSDTDTSKSKPLAQQQGINELSILLASGVLALLLVGLVPALVLITGLVIVRYGFIRLFRSQIGGYTGDTLGAAQQGSELSCYLLLLILGVSW
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYE_SACEN
Sequence: MSTPEATAEAVSGHEPNRAVRARFCPSPTGTPHVGLVRTALYNWVFARHNQGKLVFRIEDTDASRDSEESYQALLDALRWLGLDWDEGPEVGGEYGPYRQSERRDIYADIARRLLEAGELYESFSTPEEVEARHRAAGRDPKLGYDNADRDLTDEQKAAFRAEGRNAVLRLRMPEHDITFADLVRGEITFPAGSVPDPVLVRGNGDALYTLTNPVDDALMRITHVLRGEDLLSSTPRQIALYDALRRIGVTDFTPEFGHLPFVMGEGNKKLSKRDPQSNLFHHRDRGFLPEGLLNYLALLGWSISEDRDVFTLDEMVEAFEIGRVSSNPARFDQKKADAINSAHLRALAPDDFLERVVPYLVSGGVLPAEPTEEQLATVRAAAPLVQERLIVLSDAVGMMRFLFDGDDFAPDPASAEKALGEDARPVLEAAVSALEALPEWTTEAIEAALKESVVDGLGIKPRKAFAPVRVAVTGRTVSPPLYESMELLGREVSLRRLRAPLG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_CAEEL
Sequence: MAPARKGKAKEEQAVVSLGPQAKEGELIFGVAHIFASFNDTFVHITDISGRETIVRVTGGMKVKADRDESSPYAAMLAAQDVADRCKQLGINALHIKLRATGGTRTKTPGPGAQSALRALARAGMKIGRIEDVTPIPSDCTRRKGGRRGRRL
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: GSHB_RHIME
Sequence: MAGIVNVGVQMDHVSGITIAGDSTFAMSLEAQARGYRLFHYTPDKLSLRDGRVYATAQQMQLRDVRGDHFTLGEDERIDLSTMDVILLRQDPPFDMAYITSTHLLERLHPKTLVVNDPAWVRNSPEKIFVTEFPDLMPKTLITRDPDEIARFRQEMGDIILKPLYGNGGAGVFHSARDDRNFSSLLEMFAQMFREPYIAQEYLPAVRKGDKRILLVDGEPVGAINRVPAEHDSRSNMHVGGRAEATDLTAREREICTRIGPALKERGFLFVGIDVIGDYLTEINVTSPTGIREVKKFGGADVASLLWDAIEKKRA
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, GSHase, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic GSH synthase family.
Protein: ATG8_CHAGB
Sequence: MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPSDLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGNFETA
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier ATG8.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor.
Protein: EI2BA_CAEEL
Sequence: MVQESIISSFRGKLENDPSKSTSLATVETLLEVLDRSRATTVAEFQNELNQVVAALEKTDYSSTSIRSAADLFTRFTSLAPAALLDQEDFSQVLDLYRQRARSFIKNVRGSRAKISKCARLFFTHHMNILTHSYSKVVLETILDAHKSGYHLHVWVTESQPDASGKLVFEELKKNGVPTTLVLDSCVGYVMERIQAVLVGAEGVMETGGIINKIGTVNVCIIAKSRHVPVYVCAETIKFVREFPLNQADIPQEFKYRTSVIERNNLELEHPDVDYTAPEFLTLIITDVGAMKPEAVGEELIKMYI
What is the function of this protein?
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
What are the official names of this protein?
Probable translation initiation factor eIF-2B subunit alpha, eIF-2B GDP-GTP exchange factor subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family.
Protein: AK1A1_HUMAN
Sequence: MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols.  Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318).  Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes.  Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic.  Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity).  Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:18276838, PubMed:11306097).  Displays no reductase activity towards retinoids (By similarity).
What are the official names of this protein?
Aldo-keto reductase family 1 member A1, Alcohol dehydrogenase [NADP(+)], Aldehyde reductase, Glucuronate reductase, Glucuronolactone reductase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Apical cell membrane.
Protein: YFCL_ECO57
Sequence: MIAEFESRILALIDGMVDHASDDELFASGYLRGHLTLAIAELESGDDHSAQAVHTTVSQSLEKAIGAGELSPRDQALVTDMWENLFQQASQQ
What are the official names of this protein?
Uncharacterized protein YfcL.
Protein: PEN3L_PENST
Sequence: MRLVVCLVFLASFALVCQGQGYKGPYTRPILRPYVRPVVSYNVCTLSCRGITTTQARSCCTRLGRCCHVAKGYSG
What is the function of this protein?
Antibacterial and antifungal activity.  Presents chitin-binding activity (By similarity).
What are the official names of this protein?
Penaeidin-3l, Pen-3l.
What is the protein family that this protein belongs to?
Belongs to the penaeidin family.
What are the subcellular locations of this protein?
Cytoplasmic granule. Note=Cytoplasmic granules of hemocytes and to a lesser extent in small granules of hemocytes.
Protein: LACA1_STRPM
Sequence: MAIILGADAHGNALKELIKSFLQEEGYDIIDVTDINSDFIDNTLAVAKAVNEAEGRLGIMVDAYGAGPFMVATKLKGMVAAEVSDERSAYMTRGHNNARMITIGAEIVGPELAKNIVKGFVTGPYDGGRHQIRVDMLNKMA
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacA 1.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: EFTU_BUCAI
Sequence: MSKEKFQRLKPHINVGTIGHVDHGKTTLTAAITTVLSKKFGGSARAFDQIDNAPEEKARGITINTSHVEYDTEFRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRDLLTQYDFPGDDTPIIRGSALKALEGDPEWESKIIDLSKFLDSYIPEPKRAVDQPFLLPIEDVFSISGRGTVVTGRVEKGIIKVGEEVEIVGIKKTTKTTCTGVEMFRKLLDEGRAGENVGVLLRGTKRDEIERGQVLAKPGSIHPHTTFESEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGSIELPEGIEMVMPGDNIKMTVTLINPIAMADGLRFAIREGGRTVGAGVVSKVLL
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRB_VIBVY
Sequence: MGLKKFLEDIEHHFEPGGKHEKWFALYEAAATLFYTPGLVTKKSSHVRDSVDLKRIMIMVWFAVFPAMFWGMYNAGGQAIAALNHMYAGDQLAQIIAGNWHYWLTEMLGGTISADASWGSKMLLGATYFLPIYATVFLVGGFWEVLFCMVRKHEVNEGFFVTSILFALIVPPTLPLWQAALGITFGVVVAKEIFGGTGRNFLNPALAGRAFLFFAYPAQISGDVVWTAADGFSGATALSQWAQGGNSALVNTVTGAPITWLDAFIGNIPGSIGEVSTLALLIGAAMIVYMRIASWRIIAGVMIGMIVVSTLFNVIGSDTNAMFSMPWHWHLVLGGFAFGMFFMATDPVSASFTNKGKWWYGILIGAMCVMIRVVNPAYPEGMMLAILFANLFAPLFDHLVVEKNIKRRQARYGK
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit B, Na(+)-NQR subunit B, Na(+)-translocating NQR subunit B, NQR complex subunit B, NQR-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OPSB_MOUSE
Sequence: MSGEDDFYLFQNISSVGPWDGPQYHLAPVWAFRLQAAFMGFVFFVGTPLNAIVLVATLHYKKLRQPLNYILVNVSLGGFLFCIFSVFTVFIASCHGYFLFGRHVCALEAFLGSVAGLVTGWSLAFLAFERYVVICKPFGSIRFNSKHALMVVLATWIIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIIPLSLICFSYSQLLRTLRAVAAQQQESATTQKAEREVSHMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACILEMVCRKPMADESDVSGSQKTEVSTVSSSKVGPH
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity).  Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (PubMed:21219924, PubMed:25416279).  Involved in ensuring correct abundance and localization of retinal membrane proteins (PubMed:25416279).  May increase spectral sensitivity in dim light (PubMed:11055434).
What are the official names of this protein?
Short-wave-sensitive opsin 1, S opsin, Blue cone photoreceptor pigment, Blue-sensitive opsin, BOP, Short wavelength-sensitive cone opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Cytoplasm, perinuclear region.
Protein: IMPA1_PIG
Sequence: MADPWQECMDYAVTLARQAGEIVREALKNEMNIMIKSSPADLVTATDEKVEKMLISSIKEKYPSHSFIGEESVAAGEKSVLTDNPTWIIDPIDGTTNFVHGFPFVAVSIGFVVNKGMEFGVVYSCMEDKMYTGRKGRGAFCDGQKLQVSPQKDVTNSLLVTELGSSRTPETVRIILSNMERLLCIPIHGIRGVGTAALNMCFVAAGVADAFYEMGIHCWDMAGAGIIVTEAGGVLMDITGGPFDLMSRRVIASSNKALGERIAKEIQIIPLQRDDED
What is the function of this protein?
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.  Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
What are the official names of this protein?
Inositol monophosphatase 1, IMP 1, IMPase 1, D-galactose 1-phosphate phosphatase, Inositol-1(or 4)-monophosphatase 1, Lithium-sensitive myo-inositol monophosphatase A1.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GVPA_HALWD
Sequence: MAQPDSSSLAEVLDRVLDKGIVVDTFARISLVGIEILTVEARVVVASVDTFLHYAEEIAKIEQAELTAGAEA
What is the function of this protein?
Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms.  They allow the positioning of the organism at the favorable depth for growth.  GvpA type proteins form the essential core of the structure.
What are the official names of this protein?
Gas vesicle structural protein, GVP.
What is the protein family that this protein belongs to?
Belongs to the gas vesicle protein type A family.
What are the subcellular locations of this protein?
Vacuole, gas vesicle membrane.
Protein: PYRG_MYCGI
Sequence: MPALRKHPHTATKHLFVTGGVVSSLGKGLTASSLGQLLTARGLQVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRNLSGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKRRVLEMAEPDEDGNRPDVVITEVGGTVGDIESLPFLEAARQVRHEVGRENCFFLHCSLVPFMAPSGELKTKPTQHSVAALRSIGIQPDALILRCDRDVPESLKNKIALMCDVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLAFRDVDWTQWNDLLHRVHEPRETVRIALVGKYIDLSDAYLSVAEALRAGGFAHHAKVEIRWIPSDDCETDVGAATALSDVDGVLIPGGFGIRGIEGKVGAIRYARKRGLPLLGLCLGLQCIVIEAARSVGLTEASSAEFDPDTPDPVISTMADQRDAVAGEADLGGTMRLGAYPAVLQKNSLVAKAYDATEVSERHRHRYEVNNAYRERIAESGLQFSGTSPDGQLVEFVEYPADVHPFLVGTQAHPELKSRPTRPHPLFVAFVGAAVEYNNGERLPVDIPAIPTADHQSNGAEHALEDAPARG
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: APOC2_ACIJB
Sequence: MGTRCLLVLLLVLLVLRCDVQGDDMARQDEATGPTLLSQMQESLYSYWGSAKAAAQDLYEKTYLTAVDEKIRDMYSTSTAAVRIYTGILTDQILSMLSGDS
What is the function of this protein?
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma.  Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase, the enzyme which hydrolyzes the triacylglycerols on chylomicrons and VLDL.
What are the official names of this protein?
Apolipoprotein C-II, Apo-CII, ApoC-II, Apolipoprotein C2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KCNK2_RAT
Sequence: MLASASRERPGYTAGVAAPDLLDPKSAAQNSKPRLSFSAKPTVLASRVESDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQNFIAQHACVNSTELDELIQQIVTAINAGIIPLGNNSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSVKRKLSAELAGNHNQELTPCRRTLSVNHLTSEREVLPPLLKAESIYLNGLTPHCAAEDIAVIENMK
What is the function of this protein?
Does not display channel activity but reduces the channel activity of isoform 1, isoform 2 and isoform 4 and reduces cell surface expression of isoform 2.
What are the official names of this protein?
Potassium channel subfamily K member 2, Outward rectifying potassium channel protein TREK-1, Stretch-activated potassium channel TREK-1, TREK-1 K(+) channel subunit, Two pore domain potassium channel TREK-1, Two pore potassium channel TPKC1.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 5]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VSP1_BORHE
Sequence: MRKRISAIIMTLFMVFMSCNNGGPELKSDEVAKSDGTVLDLAKISAKIKEASAFAASVKEVHTLVKSVDTLAGAIGKKIKSDGKFDAMAGKNGSLLAGAYNVALDINSKLTVLDGKAGLSSLLKAKVTAAKTSGESFSNKLKTEHTDLGKEEASDDNAKAALLVTNATKNKGVTELEALNTAVDALLKAAEGEVEAAIKELTAPVKVEKPSQNN
What is the function of this protein?
The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time.  Switching between these genes is a mechanism of host immune response evasion.
What are the official names of this protein?
Variable small protein 1.
What is the protein family that this protein belongs to?
Belongs to the variable small protein (Vsp) family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: FAL1_VANPO
Sequence: MSFSREEDKKLKFKTSKKLKISPTFESMNLKDDLLRGIYGYGFEAPSAIQSRAITQIISGTDVIAQAQSGTGKTATFTIGMLQAIDLKRKDLQALVLSPTRELASQINQVVSNLGDYMNVQSYAMTGGKTMKDDLNRMQKNGCQVVSGTPGRVLDMFKRHLLNTRNVQMLILDEADELLGESLGFKQQIYDIFTKLPAACQVVVVSATMSKDILEVTKKFMSDPVKILVKRDEISLEGIKQYYVNVEKEDWKFDTLCDLYDSLTITQCVIFCNTKKKVDWLSAKLTQSNFAVVSMHGDMKQEDRNKVMSDFRSGHSRVLISTDVWARGIDVQQVSLVINYDIPEIMENYIHRIGRSGRFGRKGVAINFITSSDLSKMKEIEKYYRIKISPVPADLSTIS
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase FAL1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MSBA_BURTA
Sequence: MSVKPTLSKPIGGQDASSPAVVMRRLWPYVKPLVWVLVAGVLAMAAVAATEAGIPALLKPLLDHGFGSKGDMTTKLYVPAAVVGLALARAIAQYASGYLLQYVSNRILLDLRIQMFERMIHTGVSFFQRETASTVINAVVFEVNQVLSVLMGVMITLVRDSLTVVFLLGYLFYLNWRLTLIVAILLPCIGWLVGKINRRLRRLNREHQTLTNQLAYIVEETVGGYKVVKVHNGESYEIGRFNELSRKLRGYSMRMTVSGGLAQPLTQFLASIALAVVLTIAVVQSSNDQTTVGGFVAFVTAMLLIISPLKHLMDVNQPLQRGMTAAELIFGLIDEPREPEGGGKPLARASGAIEFSHVSFSYGISRDGRQTLDDVSFTVAPGEMVALAGPSGSGKTTLVNLLPRFFDPSSGTVRVDGVALPEYSLHDLRNQIAMVSQDVVLFNDTIAANVAYGQTPERDGVEAALRAANLWETVTAMPDGIDTLVGDNGMRLSGGQRQRLAIARAIYKDAPILILDEATSALDSESERHVQAALETLMKGRTTLVIAHRLSTIERADRILVLEGGKIVESGSHRELLEQGGLYAHLHRIQFQQDAG
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNLJ_FRASN
Sequence: MSVDERGLAADERGLAADEVGLAADERGRAAELARELEEHAYRYYVLDKPTVADAEYDALMRELEAIEERHPELRTPDSPTQKVAGSYSTLFTPVEHLERLLSLDNVFTDEEFHAWAARAAREQPVTAWLCELKIDGLAVDLVYEGGRLVRAATRGDGRTGEDITPNVRTLASVPSRLRGPAVPELLEVRGEVFFPTERFTELNAALVEAGKAPFANPRNAAAGSLRQKDPRVTASRPLDMIVHGLGAHQGFDVASQSGAYARLAELGLPVSARHEVLASVEDVLAFVRRWGEHRHDVEHEIDGVVVKVDDFGQQRRLGATSKAPRWAVAFKYPPEEVTTRLRDIQVNVGRTGRVTPFGVLEPVKVAGSTVAMATLHNIDEVGRKGVLIGDTVVLRKAGDVIPEIVSPVVDLRDGSERAFVMPTHCPECGTQLVRPEGEVDIRCPNTVSCPAQLRESVFHLASRGALDIDGLGYETATVLLAEGRIHDIGDVFHLAPESFEGLRGFADKKIEQILRGLEAARDRPLWRLLVGLSIRHVGPTAARGLARELRSLDAIATAPAERLAAVDGVGPKIADAVVDWFADPRHRDIVARIASGGVRLADEGAGEGPGPLDGVVVVITGTLDGWSRDTATEAVQSRGGKVTGSVSKKTTFVVAGADPGASKYDKARTLKIPLLDEAGFAVLLRDGADAARALAVPEEVDG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.