PharMolix/UniProtQA huggingface dataset:
Protein: NGFV2_NAJSP
Sequence: MSMLCYTLITAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPQKAEDQELRTAANIIVDPKLFQKRQFQSPRVLFSTQPPLLSRDEESVEFLDNEDSLNRNIRAKREDHPVHNLGEHSVCDSVSAWVTKTTATDIKGNTVTVMENVNLDNKVYKQYFFETKCKNPNPVPSGCRGIDSSHWNSYCTETDTFIKALTMEGNQASWRFIRIDTACVCVITKKTGN
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor 2, v-NGF-2, vNGF-2, Nerve growth factor II.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECA_PSESM
Sequence: MDDNKKKALAAALGQIERQFGKGAVMRMGDHDRQAIPAISTGSLGLDIALGIGGLPKGRIVEIYGPESSGKTTLTLSVIAQAQKMGATCAFVDAEHALDPEYAGKLGVNVDDLLVSQPDTGEQALEITDMLVRSNAIDVIVVDSVAALVPKAEIEGEMGDMHVGLQARLMSQALRKITGNIKNANCLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRTGAVKEGDEVVGSETRVKVVKNKVAPPFRQAEFQILYGKGIYLNGEIVDLAVLHGFVEKSGAWYSYQGSKIGQGKANSAKFLADNPEICKALEKQIRDKLLTPGVDTKAVGSREAVVADDVAEADADS
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFA99_HUMAN
Sequence: MAYYGKCIETVIEQLDKFTPKRDNPEQFLEAAATSLQALSPQKQSFVLEVLSGCLEYRKLLTVVVDAFYVEDGRLCLRVDHSRFEVICYLATFLLEELGFQLFCNIIKSQPVDKMCKFLRFFFNPLHLCSWIKDEWSLIYEPAHVKENWIDPLMRWQPEVQELINHLEGVSASQSSPLKTKAKVTEPKEFNLTAPRPRTIPAPEPVPVVAKPRPVPQSTYQPPKEQQQLETVKRYNRRKAEELLLRANIEELRCAMPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWEEPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARADAFPGLQAQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA
What are the official names of this protein?
Cilia- and flagella-associated protein 99.
What is the protein family that this protein belongs to?
Belongs to the CFAP99 family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum.
Protein: LIPA_DESVV
Sequence: MSSPDNSSPSLRIPPWLRVKLPCSHTFADTRALVEGLGLNTVCNSAKCPNMFECFSSGTATFLILGNVCTRNCAFCNITPGHVSPPDPDEPRRVAEAAARLALRHVVVTSVTRDDLDDGGAAHFAATITRLRAALPAATVEVLIPDFRGDHAALRTVMAAAPHIVNHNVETPPAHYARIRPQADYRQSLELLRRVKAAGGVAKSGLMVGLGENDTEVEGVLADLADCGCDIVTVGQYMRPSRQHPPVERYVHPDTFESFAACGRGMGIPFVFSAPLVRSSYNAESAYNALCTLRRKPA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_ALKEH
Sequence: MTATTQTPRHDWSKDEVLALFEQPFNDLLHQAQTTHRAHFDPNTVQVSTLLSIKTGACPEDCKYCPQSVRYDTGLEREQILAVEEVVAAARRARDAGATRFCMGAAWRSPKDRDLETVEAMVREVKALGLETCLTLGMLRDGQAERLREAGLDYYNHNLDTSEDYYDEIITTRSYQDRLDTLARVRDAGLKTCCGGIIGMGETRQDRAELLRTLASLPVQPQSVPINQLVQVPGTPLHGVEPPDPFEFVRTIAVARILMPASYVRLSAGREQMSDELQALCFLAGANSIFYGDKLLTTGNPEADKDRRLLARLGMGFEAHACAQAEAEDLG
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: SYA_STRP3
Sequence: MKELSSAQIRQMWLDFWKSKGHCVEPSANLVPVNDPTLLWINSGVATLKKYFDGSVIPENPRITNAQKSIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAIEWGFELLTSPDWFDFPKDKLYMTYYPDDKDSYNRWIACGVEPSHLVPIEDNFWEIGAGPSGPDTEIFFDRGEDFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPNKNIDTGAGLERLAAVMQGAKTNFETDLFMPIIREVEKLSGKTYDPDGDNMSFKVIADHIRALSFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGINETFLYKLVPTVGQIMESYYPEVLEKRDFIEKIVKREEETFARTIDAGSGHLDSLLAQLKAEGKDTLEGKDIFKLYDTYGFPVELTEELAEDAGYKIDHEGFKSAMKEQQDRARAAVVKGGSMGMQNETLAGIVEESRFEYDTYSLESSLSVIIADNERTEAVSEGQALLVFAQTPFYAEMGGQVADTGRIKNDKGDTVAEVVDVQKAPNGQPLHTVNVLASLSVGTNYTLEINKERRLAVEKNHTATHLLHAALHNVIGEHATQAGSLNEEEFLRFDFTHFEAVSNEELRHIEQEVNEQIWNALTITTTETDVETAKEMGAMALFGEKYGKVVRVVQIGNYSVELCGGTHLNNSSEIGLFKIVKEEGIGSGTRRIIAVTGRQAFEAYRNQEDALKDIAATVKAPQLKDAAAKVQALSDSLRDLQKENAELKEKAAAAAAGDVFKDVQEAKGVRFIASQVDVADAGALRTFADNWKQKDYSDVLVLVAAIGEKVNVLVASKTKDVHAGNMIKELAPIVAGRGGGKPDMAMAGGSDASKIAELLAAVAEIV
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCAP_I78A7
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYKRVDGKWMRELVLYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGIGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFSARSALILRGSVAHKSCLPACVYGPAVASGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRLLSFIRGTKVSPRGKLSTRGVQIASNENMDTMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFDKSTIMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: DAPB_SYNP2
Sequence: MENINKIPVVINGAGGKMGREVVKAVAGAADMEIIAAVDKNPALLGQDAGEIAGCGAVEVPIVNDLEASLVMATQSKIQGVMVDFTHPSGVYANTRAAIAYGVRPVVGTTGLSEEQINDLKEFAEKASTGALIIPNFSIGVVLLQQASLQAAKYFDHVEIIELHHNQKADAPSGTAIKTAQMLAELGKQFNPAEVEEKEEMPGAKGAVTEDNIRIHSVRLPGLIAHQEMIFGAPGQIYTLRHDTSDRSCYMPGVLLSIRKVTELNTLVYGLENIL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SH3GH_CAEEL
Sequence: MSLSGLRKQFNKANQYLSETMGAAEPTKLDDVFNEMEKNVDTTYNLITDLVAGTNEYLQPNPATRAKMATQVALSKVRGTTKTSPYPQTEGMLADVMQKYGQQLGDNSDLGKSLNDAAETYRQMADIKYQMEDNVKQNFLDPLTHLQNNELKDVNHHRTKLKGRRLDYDCKKRQQRRDDEMIQAEEKLEESKRLAEMSMFNVLSNDVEQISQLRALIEAQLDFHRQTAQCLENLQQQLGHRIKDAAARPREEHVPLSVLANESRTPRSSFRSPAPSDMSHNSTAAAAFKMPPQNGGGITQAPPSYQGPPPGGLPPPLSQQQKPQCRALFDFDAQSEGELDFKEGTLIELVSQIDENWYEGRVNGKTGLFPVTYVQVLVPLK
What is the function of this protein?
Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis (PubMed:14622579, PubMed:21029864).  By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion (PubMed:21029864).  In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels (PubMed:22157748).  Plays a minor role in responses to mechanical stimuli (PubMed:17928447).  Plays a minor role in unc-26/synaptojanin localization to synapses (PubMed:14622579).
What are the official names of this protein?
Endophilin-A homolog, Endophilin-1 homolog, Uncoordinated protein 57.
What is the protein family that this protein belongs to?
Belongs to the endophilin family.
What are the subcellular locations of this protein?
Synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Membrane; Peripheral membrane protein. Note=Localizes to neuromuscular junctions. Co-localizes with snb-1/synaptobrevin and rab-3 but not dyn- 1 and apt-4 (PubMed:14622579, PubMed:21029864). Exocytosis promotes dissociation from synaptic vesicles (PubMed:21029864).
Protein: SEP11_HUMAN
Sequence: MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVNNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNASFT
What is the function of this protein?
Filament-forming cytoskeletal GTPase.  May play a role in cytokinesis (Potential).  May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).  During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.
What are the official names of this protein?
Septin-11.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Synapse. Cell projection, dendritic spine. Cell projection, axon. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
Protein: GPP2_YEAST
Sequence: MGLTTKPLSLKVNAALFDVDGTIIISQPAIAAFWRDFGKDKPYFDAEHVIQVSHGWRTFDAIAKFAPDFANEEYVNKLEAEIPVKYGEKSIEVPGAVKLCNALNALPKEKWAVATSGTRDMAQKWFEHLGIRRPKYFITANDVKQGKPHPEPYLKGRNGLGYPINEQDPSKSKVVVFEDAPAGIAAGKAAGCKIIGIATTFDLDFLKEKGCDIIVKNHESIRVGGYNAETDEVEFIFDDYLYAKDDLLKW
What is the function of this protein?
Glycerol-1-phosphate phosphohydrolase involved in glycerol biosynthesis.  Plays a role in osmoadaptation.
What are the official names of this protein?
Glycerol-1-phosphate phosphohydrolase 2, (DL)-glycerol-3-phosphatase 2, Hyperosmolarity-responsive protein 2.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YQGF_ANAPZ
Sequence: MLCESIRELFSALEPGRRILGIDFGERKIGLALSDPTYLIAIPHSVYHRRNMRQDLGELSAVLRSEDAAVVVMGNPLQSDGLEGEMCQIVRAFAQKLIKKSGVSIYLHDERYTTAMASRATREAGLRRKESQKIDDKISAALVLQQVLDIARAEGIQATGGNNSCL
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_SYNS9
Sequence: MSRRNAAVKRPILPDPQFNSRLATMMVARLMQHGKKSTAQRILSDAFGLINERTGGDPLELFETAVKNATPLVEVRARRVGGATYQVPMEVRQERGTAMALRWLVSFSRARNGRSMSQKLAGELMDAANEAGSAVRKREETHKMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SYFB_SULAC
Sequence: MPTIVSYKWTLINNLKISDNQLEELLFKLKSEVKPIDADHVEIEVNNDRPDLFFPYGIIRAAKGILGKELGEPKYDIKQSVYSFEVKEVKSRPYAVAGIVKDIKLDDESLRELIQFQEKLHITVGRKRKKVAIGIHDLDKITSTKIYYKPLPLDYKFIPLNQSKLMTIKEVIEQTPQGREYGNISIYDGLSPAIVEENGDVLSIPPIINSDKTRIDEKTRNIFIDVTGTSFEAVSSTLDILVTDLAEMGGKIELLNFISPSKFEFSPLLRRYTVSVSANYISKNLGINLSLNEIEKYLRMARFDTKVLNDVVEVTVPPYRVDILSQIDLVEEIAMTIGYDKLSPKDYTIKATGKLSAETELIRTLRDLSIGAGFSEIFTFILSNDKRLRNEYVSIVNPVTVEYNAVRNSLIPTLLNFLKYNQHAIMPVYVFEIGDVVIKDKRTDTGYKNSLRAVYGIMNSKVNYEDLQSRVHQILMSLDIEPTYKTYLDDMFIPGRGAKIIDTSKSVEIGVIGEINPVLLEELEIEFPVVISEIYLDSLVKR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCLK_DROPS
Sequence: MEVHNSLHCTAPVLSSLQASASGSGTPKKTAASSAAAQNSKQLLDQLSQQQKAQEEAETHSRRDCDSPASSNSEPEKDLDELRDLNGSLTGSGSVGKSNGSLSGASSTTSAPAGTSTPGSANTNGSASGAASLSVVSATAHLKKRITSSRTPTRKAHRIKFYRNGDRFYPGITIPVSNERYRSFESLYEDLTRLLEENVKIPGAVRTIYDMVGKKITALEELEDGQSYVCSCNNENFKKVDYNTSSQPLANLTLANNSRTSSHRLAKLQRPASPLKNGVLNSIAPVPVGGGAAANGSPLNTSRFSERDSVVHPRIVTLIRNGTKPRRIIRLLLNKRNSPSFDHVLTAITQVVRLDTGYVRKVFTLSGVSVLQLSDFFGSDDVFFAYGTERVNTVEDFKLESEEQRAINAIRKTLRTAGTACKGPKPKMPVKSKKAYPPGELKAQAEAQLQASAAPANEDEEQAALLKSTGVEVAELPAAIRDNYTLSQIIGDGNFAIVLKIKDRQTGIPHALKIIDKSKCKGKEHYIDAEVRVMKKLHHPHIISLIMDVDQDTNMYLVLEYVSGGDLFDAITQVTRFSESQSRIMIRHLGSAMSYLHSMGIVHRDIKPENLLVELDDFGNVVQLKLADFGLACEVTEPLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGVYEFPDPYWSDIGDGVRDLIANMLQSDPDVRFTSEDILDHYWTMGNEEIGCGDYSR
What are the official names of this protein?
Serine/threonine-protein kinase GA29083, Doublecortin-like and CAM kinase-like protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Protein: IDUA_DROME
Sequence: MLSLLLVLTTLARIHAHYTSGDVVYHTMPHFWTGVGFCPAGRIDHEGISAALGDPALRLNLRLIAALPVGAVTHIRIHWLLELIQFWQYDPSGIPIYDFSKFDDFIDFLHEELRLSPVLEWMGNLGGVFSENPMQQSFYWEHLVKTTINHQIARHGSSRLVNWRYETWNEPDLRGYNKQNFTAHTFLDYVQAVRRGLSKAGNLDNQDGKVPLPMYRSLRGPAGLFKDSNHPLCWNLLELCSQRVVYCPIDILTFHRKGIEGTATEIVNGSLSLMAKIYEEYPNLKQLPVANDEADPVAGWSTSRDFQADVRYGITLISTVMQFWHAKLAGGPLSRLESISHDNAFLSYHPHEFTQRTLLAHFRMNETKPPHSQLVQKPVYAALGMLAKLGTRAADVEMVNMDTKHSVQVLRTVSGGLGGPGQYMATIFLSPEEAGPKMTAFHHKYTLNMSIANESAFVTELLVPKETDPYYIWQQAGSPAYPNATLREAMRRAQAPRLYKTGPIWQYNSELVINSASIPLPWAMLLRVCSASWPKLRRPQQLSIAEVTQREVFISWMEHPKSTQCLLSYEVWFKERDNLGRSADWMLISQGWHLPYPSFQYAPGDKGSVNGFYKVRGVDVFNETSPYSQIVEYLEL
What is the function of this protein?
Essential lysosomal hydrolase responsible for the degradation of the glycosaminoglycans (GAG) heparan sulfate and dermatan sulfate (Probable).  Required for lysosome function and autophagy (PubMed:35011691).  Consequently, has an essential role in the development, maintenance and function of various cells, tissues, and organs, including the muscles and the central nervous system (CNS) (PubMed:35011691).
What are the official names of this protein?
Alpha-L-iduronidase, D-idua.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 39 family.
Protein: PALI_MAGO7
Sequence: MLRPATPLAVLLAAAFGLLLISVLSTPIIKAIPLGEYVGVTFGVFGYCINNNARCSPIEIGYDEGLAAALADKNANFDLPSQARRTLSTILIIHPVAALVTLIMFAMSIAAHFHSPSHSARYLLIVFIVGLLNFVICLLAFLVDVLLFVPHMAWGSYLVLAATILVALSGLVACAMRRTLVSRKARKKRIEENAEMSGENFYNRQAQQVTPPAENKPTVPVVSGANGAVGDKLPSFATYEKRDDLSSEDRVPLTANSPANRSPNAQYNDPNRPDGQFNQPRRAPSGRDQYGNPMEGPTDSYGVQRAPSAERMNPGARGGYRGRGYGPPGRGGYGYGPPPGSRGGYGPPGRGGYGPGPNGRGGYGPPPRGGYGPPMRGRAPPPGYQYDRRGSPAEAYGPPPGQGPYGQRQQSPGPPSAPGYGMNGSTPTVSSAAYGHQHTPSDDLPRAESPPPLPGTEPMPPVGQAVAMDAKTGSPQVPQNGFTAMPPPNRFGGGQQFRDSDADIQGMVGLQQGITPAGQQPPSQRHQTLMSEPSHYSQEGPQYVPARQNWNDQRSKTPGAESVIHPSMMPQPLNASRTDLSISRNSPGPGGAPARSRTSEYYEDVAPRFATPDPSLRGTPVPGQAGGRIPPPINLPAGGPDFDEMPDGSRSPAASERSTFTSISQRGINPRWNPPPPSMMPGYGPAPQRRPNRNDMLLNSNPDFELPTNRGGRGGSPPRAPGTSMIPGSAYPNGRL
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
What are the official names of this protein?
pH-response regulator protein palI/RIM9.
What is the protein family that this protein belongs to?
Belongs to the palI/RIM9 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LACC_STAA8
Sequence: MILTLTLNPSVDISYPLTALKLDDVNRVQEVSKTAGGKGLNVTRVLAQVGEPVLASGFIGGELGQFIAKKLDHADIKHAFYNIKGETRNCIAILHEGQQTEILEQGPEIDNQEAAGFIKHFEQLLEKVEAVAISGSLPKGLNQDYYAQIIERCQNKGVPVILDCSGATLQTVLENPYKPTVIKPNISELYQLLNQPLDESLESLKQAVSQPLFEGIEWIIVSLGAQGAFAKHNHTFYRVNIPTISVLNPVGSGDSTVAGITSAILNHENDHDLLKKANTLGMLNAQEAQTGYVNLNNYDDLFNQIEVLEV
What are the official names of this protein?
Tagatose-6-phosphate kinase, Phosphotagatokinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
Protein: FLQE2_MYCTU
Sequence: MRAISSLAGPRALAAFGRNDIRGTYRDPLLVMLVIAPVIWTTGVALLTPLFTEMLARRYGFDLVGYYPLILTAFLLLTSIIVAGALAAFLVLDDVDAGTMTALRVTPVPLSVFFGYRAATVMVVTTIYVVATMSCSGILEPGLVSSLIPIGLVAGLSAVVTLLLILAVANNKIQGLAMVRALGMLIAGLPCLPWFISSNWNLAFGVLPPYWAAKAFWVASDHGTWWPYLVGGAVYNLAIVWVLFRRFRAKHA
What is the function of this protein?
Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export.  Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Fluoroquinolones export permease protein Rv2686c.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLYA_GEODF
Sequence: MSILENFDPAVAHAIRVETERQEFNLELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCHNVDIVENLAIDRAKELFGAEHANVQPHSGSQANMAVYFTVLKPGDTVLGMNLAHGGHLTHGSPVNFSGKFFNIVPYGVTKESQTIDYAEVERLAVEHKPKMIVVGASAYPRTIDFAAFRKIADKVGAVVMVDMAHIAGLVAAGLHPSPVPHAEFVTTTTHKTLRGPRGGMILCREEFAKALNSNIFPGIQGGPLMHVIAAKAVAFKEALSPEFKQYQQQIVNNAKALAVALMKNGFKLTSGGTDNHLMLVDLSETPLTGKVAEEALDKAGITVNKNGIPFDTRSPFITSGIRIGTPAATTHGLKEPEMAQVAGFIADALANVDNDAKLAEIKGRVNTMMKQFPLYSSRLA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COF_YERP3
Sequence: MYRLAAFDMDGTLLMRDHKIGSITLNALHQLADAGVTLTFATGRHYLDMKGILSHSGLNGYLITGNGTRVCDAEGNPLYGMDLPAELVEFVLRTPWQTNASIHLFRDDGWFTDRNDPDLLIAHTTSGFHFQLTEWDELPLTGNHKFCFIASHQELVELKAQLEQQMSGEADFCFSATDCLEVLPRGCNKGVALEKLSHHLDLTLADCMAFGDAMNDKEMLSRVGRGLVMGNALPQLKQELPQLQIIGRCEQQGVAHYLHHWLSSPHLTYSPEF
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: CSM6_ENTI1
Sequence: MKILFSPIGNTDPWRNDRDGAMLHIVRHYQPDRVVLFFTESIWQGNQHFSGQQAFDWVKIIQSINENCQIEIKCDTIEVENDFDAYKDLFHQYLVEEKRKYPNAEIFLNVTSGTPQMETTLCLEYVTYPDKMRCIQVSTPLKTSNAKTKYAQADCQEVDLEIVNEEESQQPSRCHKIAILSFREAIVRNQIKSLLDNYDYEAALQLVASQKSFRNGKEIRKKLKELIDDIKMHRVFSYLIKQYPRNEKLQKALLHTILLEMRHQRGDIAETLIRVKSIAEYIVEQYIQKNYPYLIIYKEDKPYFNVSYSQELTESYLALMDSRNKKTNKKMTVDSLDRILGFPAYRDFLQLLEASNEMTNEMNKVNEINNLRNKVAHNLDSLNLDRDKNGRKITNAVTAVRTMLLAVFPEVQENDFHYLKQFNQSIKELL
What is the function of this protein?
A single-strand-specific endoribonuclease (ssRNase) (PubMed:28722012).  Activity is stimulated by cyclic oligoadenylates (cOA); maximal stimulation is seen with cyclic hexaadenylate (cA6) (PubMed:28722012).
What are the official names of this protein?
CRISPR system endoribonuclease Csm6, CRISPR type III-A associated protein Csm6.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csm6 family.
Protein: KLEF2_ECOLX
Sequence: MPRQEPKQPGYVCPTTGRVAVLVKDYADSDLNGDASAYWFNPEAEGWGMDPWKLVEGVDPHTQGCSMDVCFADGSSKTVGPLMTFFLSAKDAARLAALKGQRQE
What are the official names of this protein?
Protein KleF, KcrB4 protein.
Protein: YICR_ESCF3
Sequence: MKNNAQLLMPREKMLKFGISALTDVELLALFLRTGTRGKDVLTLAKEMLENFGSLYGLLTSEYEQFSGVHGIGVAKFAQLKGIAELARRYYNVRMREESPLLSPEMTREFLQSQLTGEEREIFMVIFLDSQHRVITHSRLFSGTLNHVEVHPREIIREAIKINASALILAHNHPSGCAEPSKADKLITERIIKSCQFMDLRVLDHIVIGRGEYVSFAERGWI
What are the official names of this protein?
UPF0758 protein YicR.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family. YicR subfamily.
Protein: ATPF_BORPE
Sequence: MNLNATIFFQMLVFFVLGWFTMKFVWPPLTKAIDERRQKIADGLAAAEKGKADLAQAQARVSLIEASAKSETHARIIEAEKQAASMIEQARREAEAERARIVAQAAQDAAQEVQRAREALRDDVAALAVKGAEQILKREVDARAHAELLNQLKAQL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.