PharMolix/UniProtQA huggingface dataset:
Protein: CBX3_MOUSE
Sequence: MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEDFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ
What is the function of this protein?
Component of heterochromatin.  Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.  Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A.  Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.  Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (PubMed:24413057).  Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (By similarity).
What are the official names of this protein?
Chromobox protein homolog 3, Heterochromatin protein 1 homolog gamma, HP1 gamma, M32, Modifier 2 protein.
What are the subcellular locations of this protein?
Nucleus. Note=May be associated with microtubules and mitotic poles during mitosis (Potential). Associates with euchromatin and is largely excluded from constitutive heterochromatin.
Protein: RPOA_HORMA
Sequence: MVREEVAGSTQTLQWKCVESRVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGEIEGTCITRAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRDASICVKGPRYITAQDIILPPSVETVDTAQPIANLTEPIDFCIDLQIKRDRGYQTELRKNYQDGSYPIDAVSMPVRNVNYSIFSCGNGNEKHEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHAEEEGTSFEENKNRFTPPLFTFQKRLTNLKKNKKGIPLNCIFIDQLELTSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMEDRKHIWDTLEKHLPIDLLKNKLSF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AG1L2_HUMAN
Sequence: MGATAGWAVTVYDKPASFFKEAPLDLQHRLFMKLGSTHSPFRARSEPEDPDTERSAFTERDSGSGLVTRLHERPALLVSSTSWTEFEQLTLDGQNLPSLVCVITGKGPLREYYSRLIHQKHFQHIQVCIPWLEGRGLPPLLGSVDLDVCLDTSSSGLDLPMKVVDMFRCCLPACAVNFKCLHELVKHEENRLVFEDSEELAAQLQYFADAFLKLS
What is the function of this protein?
Putative glycosyltransferase.
What are the official names of this protein?
Putative glycosyltransferase ALG1L2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family.
Protein: HIS5_HALMA
Sequence: MSVRQTTADVVVVDYGLGNLRSVTRGLERAGANVSLSEDPAEFDAADGIVLPGVGAFSEGMDNAGPFREALVEQAEAGKPLFGICLGMQMLLTTSEEADHEGQGDAEGLDLIPGKNVRFSRDQTVPHMGWNELDVTRDHPLVEGVDSVGSKTPRADGTGGSVDGEHAYFVHSYYAVPDDESATVATTDYGTDFASIVANDAGNVFGTQFHPEKSGETGLRILRNYVDYCLDH
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_MYCCT
Sequence: MSFNIKEISEMIEKQIRNYNKEVVQTEQGTVVSVGDGIALIYGLDNAIMGELLLFSNNVYGMVLNLEEGAVGSVILGDETLIREGDIVKRTNKVVETPVGDALLGRVIDALGQPIDNLGPIDFTKTRPVERVATSVMARKSVSQPLETGILAIDSAIPIGKGQRELIIGDRQTGKTAIAIDAIINQKNRNVKCIYVAIGQKDSTIVQVVEKFKKYGAMDYTVVVNAGASQPASLQYLSPYTGITIAEEWMESGNDVLIVYDDLTKHAVSYREMSLLLRRPPGREAYPGDVFYLHSRLLERAARVNENYGGGSITALPIIETQAGDISAYIPTNVISITDGQIFLSSELFNQGVRPAVDIGPSVSRVGSAAQIKSIKQVSGTLKLELAQYYELESFAKFGSDLDETTKATLDQGAKIIQMLIQKQFNPLEQVDQAILLLTIKSHLLKWLPLDSIYNFKHEILSHFKNDQQAAKLRKKLDEQKTFDDQLQKEILKQAQKVVLKITKNIKEYKPEAFGNITEYQNLGK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SIEB_LAMBD
Sequence: MMSIEMDPLVILGRVFSNEPLERTMYMIVIWVGLLLLSPDNWPEYVNERIGIPHVWHVFVFALAFSLAINVHRLSAIASARYKRFKLRKRIKMQNDKVRSVIQNLTEEQSMVLCAALNEGRKYVVTSKQFPYISELIELGVLNKTFSRWNGKHILFPIEDIYWTELVASYDPYNIEIKPRPISK
What is the function of this protein?
Has a role in the prevention of superinfection by phages that are insensitive to repression.
What are the official names of this protein?
Superinfection exclusion protein B.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: Y1304_MYCBO
Sequence: MLLALLRQHIRPYRRLVAMLMMLQLVSTLASLYLPTVNAAIVDDGVAKGDTATIVRLGAVMLGVTGLQVLCAIGAVYLGSRTGAGFGRDLRSAMFEHIITFSERETARFGAPTLLTRSTNDVRQILFLVQMTATVLVTAPIMCVGGIIMAIHQEAALTWLLLVSVPILAVANYWIISHMLPLFRRMQSLIDGINRVMRDQLSGVRVVRAFTREGYERDKFAQANTALSNAALSAGNWQALMLPVTTLTINASSVALIWFGGLRIDSGQMQVGSLIAFLSYFAQILMAVLMATMTLAVLPRASVCAERITEVLSTPAALGNPDNPKFPTDGVTGVVRLAGATFTYPGADCPVLQDISLTARPGTTTAIVGSTGSGKSTLVSLICRLYDVTAGAVLVDGIDVREYHTERLWSAIGLVPQRSYLFSGTVADNLRYGGGPDQVVTEQEMWEALRVAAADGFVQTDGLQTRVAQGGVNFSGGQRQRLAIARAVIRRPAIYVFDDAFSALDVHTDAKVHASLRQVSGDATIIVVTQRISNAAQADQVIVVDNGKIVGTGTHETLLADCPTYAEFAASQSLSATVGGVG
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein Mb1304c.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. MsbA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS3_BACAH
Sequence: MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSGHVQHVQSLYLDCDQDSIVVVVKQVGPACHTGEKTCFHYKII
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAEA_BOVIN
Sequence: MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSGCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKGRQSEHDAKTGRKSRVASGSPKESEDLGMETIKGKPELSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQVMGMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNSSVFTLTLQAGLSAIKTPQCYKEDGSSRSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM
What is the function of this protein?
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.  MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex.  MAEA is required for normal cell proliferation.  The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity).  Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity).  Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity).  Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis.  Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity).  May contribute to nuclear architecture and cells division events (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein transferase MAEA, Macrophage erythroblast attacher.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Detected in a nuclear, speckled- like pattern (By similarity). Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (By similarity). Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages. Colocalizes with F-actin in macrophages (By similarity).
Protein: QUEF_CAMJJ
Sequence: MRYGEKEIKEFDVENMEIWPNDAKNDYIIKITLPEFMCCCPRSGYPDFATIYLEYMPDKFVVELKAIKLYINTFMYRNVSHEASINEIYNTLKDKLKPKWIKVVGDFNPRGNVHTVIECRSDMVVPK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCTD1_MOUSE
Sequence: MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVNAGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELRRTPRVPSVIRIKQEPLD
What is the function of this protein?
May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.
What are the official names of this protein?
BTB/POZ domain-containing protein KCTD1.
What are the subcellular locations of this protein?
Nucleus.
Protein: URED_UREU1
Sequence: MILSKEKINNYAAYLYIKVAYDEAHNKMAHTVYFTNFYRSSKPLFLDEEDPINPCFQTISMGGGYVSGEVYRSDFEVEANARCIITTQSSAKAYKAVDGKTSEQHTNITLGKNSILEYISDNVIVYEDGKFAQFNNFKMDSTATLIYTECFGPGWSPHGSAYQYEKMYLNTKIYYDNKLVLFDNLKFQPRKNDESAFGIMDGYHYCGTMIVINQEVVEEDVIKIRDLVKEKYPDMDMIFGVSRMDIPGLGLRVLANTYYHVEKINAVAHDYFRRKLFNKKPLILRKP
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XYNB_ASPKW
Sequence: MLTKNLLLCFAAAKAVLAVPHDSVVERSDALHKLSERSTPSSTGENNGYYYSFWTDGGGDVTYTNGNAGSYSVEWSNVGNFVGGKGWNPGSAKDITYSGTFTPSGNGYLSVYGWTTDPLIEYYIVESYGDYNPGSGGTYKGTVTSDGSVYDIYTATRTNAPSIQGTATFTQYWSVRQNKRVGGTVTTSNHFNAWAKLGMNLGTHNYQILATEGYQSSGSSSITIQ
What is the function of this protein?
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
What are the official names of this protein?
Endo-1,4-beta-xylanase B, Xylanase B, 1,4-beta-D-xylan xylanohydrolase B, Endo-1,4-beta-xylanase G1, Xylanase G1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 11 (cellulase G) family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM_SULAC
Sequence: MKVLVTSAWPYVNAVPHLGNLIGSILSADVFARYARLKYGKENVVFVSGSDEHGTPIEIEARKRNIEPKKLTDQAHAYDKKLFIDTWKISFDNYSRTESEVHKEFVRNFLVKLEKYIKVEEDEIPYCEKDKLFLPDRFIKGVCPYCGFEDARGDQCDNCGRLLTPRSLVNAKCALCGNPPVFKVTKHWFFDLSEFGDKIRDWISSSSTMPDNVKSVALSWVKEGLRPRSITRDNMWGIPAPFAGAENKTIYVWFEALLGYLSATVEYFKNLGKEEMWKEFWLYNDTKTYYFIGKDNIPFHAVILPAMLMASNEKYNLPSVIAATEYLLYEGQKFSKSRKIGVWIDEADKLMDVEYWRFILIRLRPEEKDTNFTWREALRIVNTELNDDIGNYANRVLSMVKRYYDGVVPSPKEAIFNDEDKNLITLIKESPKRMGELFELGKIKAGSEEILKLARSGNLYLNNRAPWSLVKTNKEEANNVLYISVNSLRTLAIMLYPIMPTYSSNLYQQLGLSNLESETWDSAGSLKIMPGHKIGEIRSLFKKIEMSPEELMKKLDEIRREVEKERPDLLR
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_MARN8
Sequence: MSNFLGSHAINMDAKGRLAIPTKVREELAQLCGGRIVLTANADEEKCLLLYPEPEWEVLRPKIEALPNMNKAAKRLQRLILGNAALMELDASGRILVPQTLRNHANLEKRLMLVGLGKKYELWSEESWNAYLDASAADEEMPPEMEALSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RPE65_MOUSE
Sequence: MSIQIEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFPDPCKNIFSRFFSYFKGVEVTDNALVNIYPVGEDYYACTETNFITKINPETLETIKQVDLCNYISVNGATAHPHIESDGTVYNIGNCFGKNFTVAYNIIKIPPLKADKEDPINKSEVVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDCFESNESMGVWLHVADKKRRKYFNNKYRTSPFNLFHHINTYEDNGFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKRNAMKAPQPEVRRYVLPLTIDKVDTGRNLVTLPHTTATATLRSDETIWLEPEVLFSGPRQAFEFPQINYQKFGGKPYTYAYGLGLNHFVPDKLCKMNVKTKEIWMWQEPDSYPSEPIFVSQPDALEEDDGVVLSVVVSPGAGQKPAYLLVLNAKDLSEIARAEVETNIPVTFHGLFKRS
What is the function of this protein?
Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins.  Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:15765048, PubMed:9843205, PubMed:23407971, PubMed:28500718).  Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17251447).  Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid.  The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester.  The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol.  The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).
What are the official names of this protein?
Retinoid isomerohydrolase, All-trans-retinyl-palmitate hydrolase, Lutein isomerase, Meso-zeaxanthin isomerase, Retinal pigment epithelium-specific 65 kDa protein, Retinol isomerase.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor. Microsome membrane. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated. Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells (By similarity).
Protein: COBT_GEODF
Sequence: MSLIDDTLEQIKAVDPALLAEAQVVLDNKTKPPGSLGRLEEFARRYVAIIADPENSDLELLGTKVVYTFAADHGVVEEGISLYPKEVTQQMVLNFLNGGAGVNVLARHVGAEVRVVDIGVDYYFGMVPGLVVRKVARGTANLAQGPAMTREQAVAALEVGIGLAAQAKKTGVTMLGTGEMGIGNTTPSSAIIAAISGKTVKEVTHRGTGINDAALENKIRVIEQGLAVNKPDPKDPIDVLAKVGGLEIAGIAGLILGAAANRIPVVVDGFISTAGALIASELNPHVKDYMFAAHESVEIGHSFMLQHIGLKPILDLQLRLGEGTGAALAMGLIEAGVKIYKEMATFAEAGVASE
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RL27_DICTD
Sequence: MAHKKSGGASRNGRDSNPKYLGVKRFEGQLVEAGNILVRQRGTKIYPGMNVGMGRDFTLYALQPGIVKFSIKHGKKYVNVLSIQ
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: IF2_GEODF
Sequence: MSKTRVYELAQQMGIDNKELMAKLAAVGVEVKNHMAAIDDADIKKLSAPATVKEVSQEEVRVKPTLIRRRAKVVEAVAEEPPVEPKAEPAPAEVTTEKVAEKARVEEAPAPEAPVQAAEPVKIATEEAVPERATANKAKILGRVEIPGLTQRAKPPVQREAQPTARVVERPEARPSAERPAPGQRPEGQRPGQRPEGGYRPAGPRPAGQRPEGPRPGYTERPVTRGPERPGQARGPERPAPVVPLEMPPAGEDRRKGRKGKEVAGAGKKGPAGAAVPKRKEEFKKTELFEKHERVFEPGPRGKGKKRQAEKIQIGKKTEITVPKAIKRIIKISETITVGELAKRMGIKANDLIRALMKMGVMATINHALDFDTATILATDFGYEIENVALDIDEILESTPDTPESLVKRPPVVTIMGHVDHGKTSLLDAIRQTNVIAGEAGGITQHIGAYDVTLNGRKITFLDTPGHEAFTAMRARGAKVTDIVILVVAADDGVMPQTREAVNHSKAAGVPIIVAVNKIDKPEAKPERVKQELMELGLVSEEWGGETIFVDVSAKKRVNLPTLLEMVLLQADVLELKANEDKAARGTIVEAKLDKGRGPVATVLVQEGTLKVGDYFVAGIHFGRVRAMQNDRAEKVLSAGPSMPVEVIGFTGVPDAGDVFVALADEKQAKEIASLRQQKVRETELAKHSKLSLEQLYEKIQMGEVKDLNTIVKGDVQGSVEAVSESLRKLSTDAIRLNVIHASVGAITETDVNLATASNAIILGFNVRPEVKAQALAEKEGVDIRLYNIIYDAVDDIKKAMEGLLEPTLREKFLGRAEVRETFSVPKHGTVAGSYVLDGKMIRNSQVRLLRDNVVVFEGKMGSLRRFKDDVKEVASGYECGISIENYNDIKVGDIIESFEMEKVATKL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSFX3_HUMAN
Sequence: MASQNTEQEYEAKLAPSVGGEPTSGGPSGSSPDPNPDSSEVLDRHEDQAMSQDPGSQDNSPPEDRNQRVVNVEDNHNLFRLSFPRKLWTIVEEDTFKSVSWNDDGDAVIIDKDLFQREVLQRKGAERIFKTDSLTSFIRQLNLYGFCKTRPSNSPGNKKMMIYCNSNFQRDKPRLLENIQRKDALRNTAQQATRVPTPKRKNLVATRRSLRIYHINARKEAIKMCQQGAPSVQGPSGTQSFRRSGMWSKKSATRHPLGNGPPQEPNGPSWEGTSGNVTFTSSATTWMEGTGILSSLVYSDNGSVMSLYNICYYALLASLSVMSPNEPSDDEEE
What are the official names of this protein?
Heat shock transcription factor, X-linked member 3.
What is the protein family that this protein belongs to?
Belongs to the HSF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYSA_RHILO
Sequence: MEVRVANVRKEFERFPALHDVSLDIKSGELIALLGPSGSGKTTLLRLIAGLERPTRGKIFFGDEDASQKSIQERNVGFVFQHYALFRHMTVADNIGFGLKVRHGSSRPPAQEIRRRASELLDLVQLSGLEKRYPAQLSGGQRQRVALARAMAIEPKVLLLDEPFGALDAQVRRELRRWLREIHDRTGHTTVFVTHDQEEALELADRVVVMSQGRIEQVGTADDIYDTPNSPFVYGFIGESSSLPVKVENGEIWLADRPIGLSAPHAPEGEATLYFRPHDVELLDGCSGCIAGTVAASRRVAGTRRVELEIGGERQRVEIELPVGHPAAQKSRVAFRPGRWKLFPAA
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LCAT_PIG
Sequence: FWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNPDVVNWMCYRFTIWLDLNMFLPLGVDVPGFGKTYSVEYLDNSKAAPYDWRLEPSQQEEYYLKISLGAPWGGSDLHFEEGWYDLLAGLPAPGVEVYCLYGVGLPTPRXYIFDXGFPYXDPVQQQPVHLLPLPGTQHLNMVFSXQTLEXINAILLG
What is the function of this protein?
Central enzyme in the extracellular metabolism of plasma lipoproteins.  Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs).  The cholesterol ester is then transported back to the liver.  Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels.  Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins.  Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).  Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107).  Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity).  Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity).  Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity).
What are the official names of this protein?
Phosphatidylcholine-sterol acyltransferase, 1-alkyl-2-acetylglycerophosphocholine esterase, Lecithin-cholesterol acyltransferase, Phospholipid-cholesterol acyltransferase, Platelet-activating factor acetylhydrolase, PAF acetylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into blood plasma (PubMed:8820107). Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (By similarity).
Protein: NHAP2_CROS8
Sequence: MDAGTIISLFILGSVLVTCSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYLISNLALAVILLDGGMRTQASSFKVALGPALSLATVGVLITSGLTGMAAAWLFHLDIMEGLLIGAIVGSTDAAAVFSLLGGKGLNERVSSTLEIESGSNDPMAVFLTITLISMIQEHQTALSWLFLVHIIQQFGLGILIGLGGGWLLLKTINRIPLPSGLYPLLALSGGIMVFSVTTALDGSGILAVYLCGFVLGNKPIRNRYGIQQTFDGLAWLAQIGMFLVLGLLVTPSHLLPIAIPALLLSLWMIFVARPLSIFTGLLPFRGFTLRERVFISWVGLRGAVPIILAVFPMMAGLPRANLFFDVAFFVVLVSLLFQGTTLGWAAKKAKVVVPEVGRPQSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKETRIAALFRENQLMHPTGSTRLREGDVLCVIGRERDLPALGKLFSQSPPVALDQRFFGDFILEADAKFSDVAFIYGLDDQSAVDQNRTIGEVVLALIGAAPVVGDQVDFAGMTWTVAEKENNQIRRIGLKVAEDSDE
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MRAZ_LACPL
Sequence: MFFGEFEHALDAKGRLIIPAKFRELLGTSFVITRGMDGCIFGYPAERWATLQAQLDDLPLTRKDARAFVRFFYAAAAECELDKQGRVMIPATLRQYAKLEKQCVIVGVSDRFEIWGAEHWQQFETETAANFDDLAENLIDF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.