PharMolix/UniProtQA huggingface dataset:
Protein: TILS_BACCR
Sequence: MKDTFVEKVDDFVKQHDVLKNDSTIVVGVSGGPDSLALLYYLLEKRAEKQLEIVVAHVDHMFRGDESYEDLQFVQGLCEELGIICETIRINVSQYQQQYGMNAQVAARECRYAFLERIMKKYDARYVALGHHGDDQVETILMRLVRGSTPKGYAGIAVKRPFHNGYLIRPLLGVTKEEIVDYCNKLNLMPRIDPSNKKEVYTRNRLRKYVLPHLKEENPQMHEKFQKFSVQMQEDEAYLQELAFEKMNKVITKKSDKQISLSIPAFESMSMPLQRRGIQLILNYLYEYKIPSSLSSIHIDKLIEFFKRTQPSGSLDFPGDLKIVRSYEECSFRFKQEIVSPFSQDLLVPGTITLLNGDKFVTEVSEDIPSNMNETVFVAKYNDISYPLRIRSRENGDRMSIQGMNGTKKIKAIFIEAKVPKEKREEWPVVCDASGTIIWVPLLKRSAFAISKEMAKKDKYMIIHYKSKESSGRIMK
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEP2_MOUSE
Sequence: MKHPLCTLLSLITFMCIGSKGLAEQLTNENLTTSFLPANFHKENTVTNDWIPEGEEDEDYLDLEKLLGEDDDYIYIIDAVSPTDSESSAGNILQLFQGKSRIQRLNILNAKFAFNLYRVLKDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEVHSVLHFRDFVNASSKYEVTTIHNLFRKLTHRLFRRNFGYTLRSVNGLYIQKQFPIREDFKAAMREFYFAEAQEANFPDPAFISKANNHILKLTKGLIKEALENIDPATQMLILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGISDQRIAIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVTNPAKS
What is the function of this protein?
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate.  In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT).  Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
What are the official names of this protein?
Heparin cofactor 2, Heparin cofactor II, HC-II, Protease inhibitor leuserpin-2, Serpin D1.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
Protein: MSCL_BACC3
Sequence: MWNEFKKFAFKGNVIDLAVGVVIGAAFGKIVSSLVKDIITPLLGMVLGGVDFTDLKITFGKSSIMYGNFIQTIFDFLIIAAAIFMFVKVFNKLTSKREEEKEEEIPEPTKEEELLGEIRDLLKQQNSSKDRA
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: K1H2_MOUSE
Sequence: MPSVCMPTTYRPASCLSKTYLSSSCQPSNRRPTGCISSSMGTYGLFCEGAFNGNEKETMQVLNDRLANYLEKVRQLEKENAELEGKIQDVYQGQVLTMCPDYQSYFQTIEELQQKVLCTKAENARMIVHIDNAKLAADDFRTKYETELALRQLVEADTNGLRRILDELTLNKADLEAQVESLKEELLCLKRNHEEEVGVLRQQLGDRLNIEVDAAPPVDLTRMLEEMRCQYETMVETNHRDVEEWFNMQMEELNKQVATSSEQLQSYQSDIIDLRRTVNTLEIELQAQHSLRDSLENTLGETEGRFTSQLSQMQCMITNVESQLSDIRCDLERQNQEYKVLLDVKARLECEIDTYRGLLESEDSKLPCNPCSTPSCQPCAPSPGVSRTVCVPHTVCVPCSPCLQTRY
What are the official names of this protein?
Keratin, type I cuticular Ha2, Hair keratin, type I Ha2, Keratin-32, K32.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: ALBU_BOMMX
Sequence: MKWTILTALLIISAESKNLYKRDSEPHIRFLGEVYKKVDTIDFRGLVLITLAQHLQKCPFEELAKQVEQITTLAQACAAGARHADCATPLITLFLNRICAVPELSATYDWSTECCAKSDPERHQCFRAHRNPAPGTHYKRPEPEELCESYKKNKEDVLAHYIYEVSRGHPVLYSPAVLGFAYQFNGICSHCCEEEDKTTCFKDRMTQLKKALHIVEVQQKESCRILDNFGVRVLQALKLVKISKKNPKATFEVAQKLTSEVTHLNEDCCHGDMLECMIERMELTEHTCEHHEDISTKLKTCCEKPLIERTHCIVNLENDDIPEDLPKKVTKFVEDPEVCKLFADKKDIFLAEFLYEYGRRHPELSDQLLLRIAKGYEHQLEKCCELENFLECLKDGEHVLADAIKESTELTEKDCAIQQKLGDYLFQNVLLIRYTKKMPHVTTPSLIHITKHMTEVGDKCCALPNTQKMPCAEGGLSLIIGEFCEMEKTHPINEHVKNCCWKSYSNRRNCFTNLGPDDSYVAPEITDDTFHFTEDLCTLPEEELKNKKQGFIATLVKVKPHVTDELYGQIAVEFTKMREKCCAAEDHQACFNAEEPILIEHCKQLAA
What is the function of this protein?
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs.  Its main function is the regulation of the colloidal osmotic pressure of blood (By similarity).  Potent inhibitor of trypsin but has no inhibitory effect on thrombin, chymotrypsin, elastase and subtilisin.
What are the official names of this protein?
Serum albumin, BmA-serum, BmA-skin.
What is the protein family that this protein belongs to?
Belongs to the ALB/AFP/VDB family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSRP_METCA
Sequence: MSSKKSAPGSANIAQNRQATHEYFIEERLEAGLVLEGWEVKSLRAGKAQLKESFVMLKNGEAWLFGAHFSPLPSASTHVQPDPTRSRKLLLHAEELSRLIGQVERKGYTLVPLSLYWKQGRAKLEIGLARGKKQHDKRAAEKERDWEREKQRVMRRG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: AP3M_SCHPO
Sequence: MSTIEAIYLVDTNGALLLQLESRGRTSPITLEHIKNELFRYKLRNEEPPFILHNKNFLIFQELEEDVRLCIPTTCDTEPLYIHDIMRRIVDVVKTFFGGFNASKVEKNVCVIVQLLAEMIDYGYATCMEPNALQDIVPLPSFMNKFMAVTGLQTNTPTLARDTVPWRTAKAKYATNEFFIHVLERVSAVYQPNGKLAFGTVKSDMECKCQISGMPLLLLSLRPGTKLGNVRFHQSVNLKRWKQHPDQIEFIPPDGKFTLASFQTDFATQKSLPVVVEAKNKLDGRFEVRIRNTGKKSVENLKILITIPQALKSVTVTEGNYIFRASKYTHMEEGILEWSVKKLAWTSPALVLTGFLAPLKKDANSTEESSSYSKLEHLDLQYKLQGSTLHNFKVESLKMLNHPDKKSYKGVKHTIIAQNVSFRFR
What is the function of this protein?
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated.  The complex is associated with the Golgi region as well as more peripheral structures.  It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).
What are the official names of this protein?
AP-3 complex subunit mu, Adaptor-related protein complex 3 subunit mu.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Membrane; Peripheral membrane protein. Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes at the cell tip and the barrier septum (PubMed:16823372). Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity).
Protein: CYSK2_CAEEL
Sequence: MSRELMVETGGELIGNTPLLKLNKIGKDLGASIAVKVEYMNPACSVKDRIAFNMIDTAEKAGLITPGKTVLIEPTSGNMGIALAYCGKLRGYKVILTMPASMSIERRCLLKAYGAEVILTDPATAVKGAVQRAEELRDVIPNAYILNQFGNPANPEAHYKTTGPEIWRQTQGKVDIVCFGVGSGGTCTGVGRFLKEKNPSVQVFPVEPFESSVINGLPHSPHKIQGMGTGMIPDILDLTLFSEALRVHSDDAIAMAKKLADEESILGGISSGANVCAAVQLAKRPENKGKLIVTTVNSFGERYLSTALYAELRDNAANMKQLNLDDSIKIAKEYLGI
What is the function of this protein?
Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide.  Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from either S-sulfocysteine or O-acetylserine and hydrogen sulfide (PubMed:24100226).  By catalyzing the assimilation of cyanide produced by P. aeruginosa, mediates resistance to infection (PubMed:21840852).  Involved in fertility, growth and aging (PubMed:24260346).  Does not mediate survival in high levels of hydrogen sulfide (PubMed:21840852).
What are the official names of this protein?
Bifunctional L-3-cyanoalanine synthase/cysteine synthase, CAS, O-acetylserine (thiol)-lyase 2, OAS-TL.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: YOPA_BACSU
Sequence: MENIALESSFLEYDINEPIKIYTGHFTIEVADDFFEILGEVKIAFLPKARLIFEGAISGNLSKLFEFEKAMKSNNMMINVPGFMKSEVLISGITDGSKGNKVSGILKRSILTSAETKVNRMEFTVVNFVNDLGRRIVHGRFKFSGRTKLKYKDWEIILDKRYDYSNKKIFDRLKNSGGYLITHVGYLKRVDDKLFDTKEVEPLISGLYWLLSFSAGRHVAIPTLEGYHNEEVIWSKYQVPLIDGWTNNITWFPKQKSPSLEHLFPKVIEKQEDPFWNKVLWEVLSWYSQAHSSSIVENKVVSVQVALETLAWVYLIVDRKSNISKSKYKYMNAAEKFREILSRFSIDLSIPKLFIDIKDNYDDGPHLFTVFRNKIVHPTRELDFDNPIDKLHVLYLGVWYLELLTLGILGYEGSYVNRLKVPIIEGVYEFVPWKTRDN
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YopA.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RS20_FRACC
Sequence: MANIKSQIKRNLTNEKRRLRNKAVKSELKTHVRRFRDAVDAGDVERAGETLRIASRKLDKAVSKGVIHANQAANKKSALARTHANLAAS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: LOLA_VIBVU
Sequence: MKKWLVVFFLSASALANPQQELNQRLGMNDGFSANFNQTVTSPEGEVVMEGEGSVDIARPSLFRWSTSLPDENLLVSDGKTLWYYSPFIEQVSIYWQEQAVQQTPFVLLTRNQSSDWENYQITQDGNVFTLVPKAADSTQGQFQIDIDAKGIVHGFNVIEQDGQKGIFKFTDMKLGKPAAARFTFNIPEGVEVDDQRN
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MDTH_SODGM
Sequence: MSSVSQARSLGKYFLLMDNMLVVMGFYVVFPLISIRFVDQLGWAALLVGIALGLRQFIQQGLGIFGGAFADRLGAKPMIIAGMLMRALGFVLMGIADEPWLLWLSCALSALGGTLFDPPRTALVIKLTRPWERGRFYSLLMMQDSACSVIGALLGSWLLRYDFKLVCLAGAVLFVFAAIFNAWLLPGYRISTVRAPMLEGMRRVLRDQRFVTYVLTLTGYYMLSVQVMLMLPIRINEVAGQPAAVKWMYAIEAALSLSLLYPIARWSEKRFRLETRLMAGLTVMLLSLFPIGLIEDLRALFMLIGLFYIGSIIAEPARETLGASLADNRARGSYMGFSRLGLALGGAIGYSGGGWLYDVGNRLEIPQLPWFMLGLIGFITLLGLYRQFQQRPIEPAMLNGRGEGS
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUOK_ECOL5
Sequence: MIPLQHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IOLE_BACVZ
Sequence: MGKQDILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVAGFQGTEVGGFFPEPSVLNKELALRNLRIAGKWFSSFIIQDGIEKMAEQFTEHCDYLQKVGADVAIVSEQTYSVQGLDIDVFKEKPHFSDEEWDTLCQGLNRLGKIAGEYGLDLTFHHHLGTGVQTAEEVDRLMDGTDPRYVHLLYDTGHAYISDGDYMTILNKHMDRIRHVHFKDARFDIMERCRQEGKSFRQSFLQGIFTVPGDGCIDFTEVYRTLVRHDYSGWIVIEAEQDPAVANPLEYALIARKYIDSELLDPAN
What is the function of this protein?
Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).
What are the official names of this protein?
Inosose dehydratase, 2-keto-myo-inositol dehydratase, 2KMI dehydratase.
What is the protein family that this protein belongs to?
Belongs to the IolE/MocC family.
Protein: UXUA_MANSM
Sequence: MEQTWRWYGPNDPVSLADIRQAGATGIVNALHHIPNGQVWSVEEIEKRKAIIEAAGLTWSVVESVPVHEEIKTQTGNYKTWIENYKQTLRNLAQCGIDTVCYNFMPVLDWTRTDLAYELPDGSKALRFDQIAFAAFELHILKRPGAEQTYTAEEQKQAKAYFDKMSDADIKQLTSNIIAGLPGAEEGYTLEEFQGQLDRYKDISPEKFRTHLAYFLNEIIPVAQEVGIKMAVHPDDPPRPILGLPRIVSTIEDMQWYVDTCDLPANGFTMCTGSYGVRADNDLVKMTEKFGDRIYFAHLRSTCREDNPLTFHEAAHLQGDVDMFNVVKALLTEEYRRKANGETRLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEFRGLEMALKKVFFEK
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: APOE_MUSPA
Sequence: MKALWAVLLVTLLAGCLAEGEPEVTDQLEWQSSQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVHTMLGQSTEEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSALRERLGPLVEQGRQRTANLGAGAAQPLRDRAQAFGDRIRGRLEEVGNQARDRLEEVREHMEEVRSKMEEQTQQIRLQAEIFQARLKGWFEPIVEDMHRQWANLMEKIQASVATNPIISTPMPQENQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: FFSJ_ASPFV
Sequence: MRLTRALTPAILALPAAHAAASLQDWQSLNTTLDHRLHAVTPLALPCFSIYNNHSHAPNEDACLNIQDHYTNASYRVDQVSAYVFSQSETCSPIPSQQCELDPSDPSNPAAYTNISCNTGSLPAYYIDVQHASDVTAAFHFAAKTNTAISIKNSGHDYNGRSSGPGSLSLRTRTLRSTTYHPSFTPASCKTPTGKAVTLGAGVNFHEVYTFAHENKVTFVGGSGPTVGASGGWVLTGGHGVLSRAYGLGIDRVVEFELVTPDGEHRIANACQNADLFWALRGGGGSTFGVVLSSTHRVEPEAPLSLAYLALPPNASSSTSAAFLDLLVNYTLPWAEDAWGGFGNAAATILATPLLSLPEAKTSMATAIDFVTAHGGTGYVETLSSFYEMYTKYIVPSASAVGSVRFNHNWIIPNSLFATASGQKKLRKHLDWMGSVGLVPGLLETTPYLYSGNGHGRSNNNNSNNSSTSTSTSTSSKNGSVKPYAYGGKETTSSTPAWRNSAAVLIAEVGWAFNATLSEKKALAKTLVEASERVRELAPGSGAYANEAHPWVEDWQDAFWGGNYRRLADLKKKWDPKGLLGCWHCVGSEGEGKKETGTAWRAEVVGGKCLGRLI
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the cytotoxic leucine-containing cytochalasans, including aspochalasin C, aspochalasin E, TMC-169, flavichalasine F, aspergillin PZ, aspochalasin M and flavichalasine G (PubMed:32913332).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS ffsA that utilizes 8 units of malonyl-CoA to iteratively assemble the octaketide chain before addition of L-leucine by the C-terminal NRPS modules (PubMed:32913332).  Because ffsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase fssC (Probable).  The methyltransferase (MT) domain of ffsA catalyzes the alpha-methylation at C10 and C14 using S-adenosyl-L-methionine as the methyl-donating cosubstrate (Probable).  Reduction by the hydrolyase ffsE, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ffsF then yield the required isoindolone-fused macrocycle (By similarity).  A number of oxidative steps catalyzed by the tailoring cytochrome P450 monooxygenase ffsD, the FAD-linked oxidoreductase ffsJ and the short-chain dehydrogenase/reductase ffsI, are further required to afford the final products (Probable).
What are the official names of this protein?
FAD-linked oxidoreductase ffsJ, Cytochalasans biosynthesis cluster protein ffsJ.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: GLYA2_VIBCH
Sequence: MNANLNKAYPNVSLENFFSTPLAATNDAVFAAIQAEYTRQNEQIELIASENIVSKAVMQAQGTCLTNKYAEGYPGRRYYGGCEHVDSVEQIAIERAKMLFQCQYANVQPHSGAQANGAVMLALLQPGDTIMGMSLDAGGHLTHGARPALSGKWFNAVQYGVDRQTLEINYDSVRALALEHKPKMIIAGGSAIPRTIDFAQFRSIVDEVGALLMVDMAHIAGLVATGAHPSPLPHAHVVTTTTHKTLRGPRGGMILTNSEEIHKKINSAVFPGLQGGPLMHVIAAKAVAFGEALGPEFRTYIDSVIDNAKVLAEVLQTRGCDIVTGGTDTHLMLVDLRPKGLKGNQVEQALERAGITCNKNGIPFDEEKPMITSGIRLGTPAGTSRGFGREEFKLIGEWIGDVLDGLVASPEGNPDVEQQVRKQVKALCQRFPLYQ
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 2, SHMT 2, Serine methylase 2.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_LACLS
Sequence: MTEVNINVTEIMEALPHRYPFLLVDRVIDIADDEITAIKNVTINEEFFQGHFPQYPVMPGVLIMEALAQAAGVLELSKPENKGKLVFYAGMDNVKYKKQVTPGDQLVLHAKFIKRRGPIAVVEAEATVDGKLAAKGTLTFALGK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT24_CAEEL
Sequence: MLRSIQHVEALSSRQISTTSMLLKNRAGKTKSTSNRTQLLTYEMAQKPHHIGVRKSWLTWHSQNLEEFRQSQPLVVAQDEVVRRFIRGFFPQNLVVSGNEIVIKRRGNVLIVAGFLQYSRRLDIRRIYWMFGFAEEFLSILLKQPVKLEMAFVESEEDVAYNYI
What are the official names of this protein?
28S ribosomal protein S24, mitochondrial, MRP-S24, S24mt.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: THIK_SALCH
Sequence: MRSNNNNPLTRDEILSRYFPQYRPAVAASQGLSGGSCIIAHDTHRVVLRRHHDPDAPPAHFLRHYRALSQLPASLAPRALFYTPGWMAVEYLHGVVNSALPDADELAALLYHLHQQPRFGWRIALSPLLAQYWSCCDPARRTPFWLRRLKQLQKNGEPRPLRLAPLHMDVHGDNIVLTSAGLRLIDWEYAGDGDIALELAAVWVEDERQHRQLANAYAACARIDARQLWRQIRLWHPWVIMLKAGWFEYRWRQTGEQQFIRLADETWRQLRMKG
What is the function of this protein?
Catalyzes the phosphorylation of thiamine to thiamine phosphate.
What are the official names of this protein?
Thiamine kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine kinase family.
Protein: FBID_SALAI
Sequence: MTQVWTVVVPVKRLGVAKSRLRGALPDQPHEALALALAVDTVSAVLACPVVADVLVVTDDPAVATETGMAGARVVPDRPAAGLNSAVRHGAATAGAGWIAGLTADLPALRPAELAAALSAARTGPTSRRYLPDAPGTGTVLLAAPPGVPLNPRFGGSSAAAHAASGALALLGDWPSLRRDVDTATDLAEAARLGLGPRTALLCGTAAPTAGRSV
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
Phosphoenolpyruvate guanylyltransferase, PEP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: CCL26_CANLF
Sequence: MKSFPVAFLVLLIFILSVHRGVTTRGSDVAKFCCFQYSHKILPWKWIQSYKFTRSSCSQQAVIFTTKKGHKVCAQPKEKWVQRYIALLREQQQS
What is the function of this protein?
Chemoattractant for eosinophils and basophils.  Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils.  Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis.
What are the official names of this protein?
C-C motif chemokine 26, Eotaxin-3, Small-inducible cytokine A26.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.