PharMolix/UniProtQA huggingface dataset:
Protein: ZN736_HUMAN
Sequence: MGVLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLGLAIFKPDLMTCLEQRKEPWKVKRQEAVAKHPAGSFHFTAEILPDHDIKDSFQKVILRKYGSCDLNNLHLKKDYQSVGNCKGQKSSYNGLHQCLSATHSKTCQCNKCGRGFQLCSIFTEHKDIFSREKCHKCEECGKDCRLFSDFTRHKKIHTVERCYKCEECGKAFKKFSNLTEHKRVHTGEKPYKCEGCGKTFTCSSTLVKHKRNHTGDRPYKCEECGKAFKCFSDLTNHKRIHTGEKPYKCEECNKAYRWFSDLAKHKIIHTGDKPYTCNECGKAFKWFSALSKHKRIHTGEKPYICEECGKAFTRSSTLFNHKRIHMEERPYKCEECSKTFKCFSDLTNHKRIHTGEKPYKCEECGKASSWFSHLIRHKRIHTREKLHKC
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 736.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TNNC2_HUMAN
Sequence: MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ
What is the function of this protein?
Troponin is the central regulatory protein of striated muscle contraction.  Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.  The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
What are the official names of this protein?
Troponin C, skeletal muscle.
What is the protein family that this protein belongs to?
Belongs to the troponin C family.
Protein: RUVB_SHESR
Sequence: MIEADRLIQPQLQGQDDVIDRAMRPKLLDEYTGQDDTRAQLKVFIQAAKNREEALDHMLIYGPPGLGKTTLAMIVANEMGVNIKSTSGPVLEKAGDLAALLTNLEAGDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGALTSPLRARFGIPLRLEFYNVKDLSTIVSRSAQVMGLAIDSEGAIEIAKRSRGTPRIANRLLRRVRDYAEVKHDGAVTKKVAEHALDLLDVDGEGFDYMDRKLLLAIIDKFMGGPVGLDNLAAAIGEERETIEDVLEPFLIQQGFIQRTPRGRIATNRAYLHFGMIKPE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RS15_CUTAK
Sequence: MDAAEKKKIIEEYATHPGDTGSPDVQVAILTKRIAELTEHLKVHKGDHHSRRGLMLMVGQRRRLLNYIAKNDIEHYRELIARLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SMP07_NAUMA
Sequence: LYSLLTEK
What are the official names of this protein?
Uncharacterized protein SMPP7.
Protein: EST2_PSEFL
Sequence: MTEPLILQPAKPADACVIWLHGLGADRYDFMPVAEALQESLLTTRFVLPQAPTRPVTINGGYEMPSWYDIKAMSPARSISLEELEVSAKMVTDLIEAQKRTGIDASRIFLAGFSQGGAVVFHTAFINWQGPLGGVIALSTYAPTFGDELELSASQQRIPALCLHGQYDDVVQNAMGRSAFEHLKSRGVTVTWQEYPMGHEVLPQEIHDIGAWLAARLG
What is the function of this protein?
Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity.
What are the official names of this protein?
Carboxylesterase 2, Esterase II.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Protein: RPE5A_ARATH
Sequence: MEVKGKETASVLCLSKYVDLSSEESHRYYLARRNGLQMLRDRGYEVSDEDINLSLHDFRTVYGERPDVDRLRISALHRSDSTKKVKIVFFGTSMVKVNAIRSVVADILSQETITGLILVLQNHVTNQALKAIELFSFKVEIFQITDLLVNITKHSLKPQHQVLNDEEKTTLLKKFSIEEKQLPRISKKDAIVRYYGLEKGQVVKVNYRGELTESHVAFRCVW
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase V involved in RNA-directed DNA methylation-dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements.  Required for establishment of DNA methylation.
What are the official names of this protein?
DNA-directed RNA polymerase V subunit 5A.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BGLR_RAT
Sequence: MSPRRSVCWFVLGQLLCSCAVALQGGMLFPKETPSRELKVLDGLWSFRADYSNNRLQGFEKQWYRQPLRESGPTLDMPVPSSFNDITQEAELRNFIGWVWYEREAVLPQRWTQDTDRRVVLRINSAHYYAVVWVNGIHVVEHEGGHLPFEADITKLVQSGPLTTFRVTIAINNTLTPYTLPPGTIVYKTDPSMYPKGYFVQDISFDFFNYAGLHRSVVLYTTPTTYIDDITVTTDVDRDVGLVNYWISVQGSDHFQLEVRLLDEDGKIVARGTGNEGQLKVPRAHLWWPYLMHEHPAYLYSLEVTMTTPESVSDFYTLPVGIRTVAVTKSKFLINGKPFYFQGVNKHEDSDIRGRGFDWPLLIKDFNLLRWLGANSFRTSHYPYSEEVLQLCDRYGIVVIDECPGVGIVLPQSFGNVSLRHHLEVMDELVRRDKNHPAVVMWSVANEPVSSLKPAGYYFKTLIAHTKALDPTRPVTFVSNTRYDADMGAPYVDVICVNSYLSWYHDYGHLEVIQLQLTSQFENWYKMYQKPIIQSEYGADAVSGLHEDPPRMFSEEYQTALLENYHLILDEKRKEYVIGELIWNFADFMTNQSPLRVTGNKKGIFTRQRNPKMAAFILRERYWRIANETRGYGSVPRTQCMGSRPFTF
What is the function of this protein?
Plays an important role in the degradation of dermatan and keratan sulfates.
What are the official names of this protein?
Beta-glucuronidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: Y1357_BACC7
Sequence: MQNKIQVKSVEKRENALIFCAENSEIEVKELSARNHVLVDSDNLSFLYILENESSFIYVSIPHTCWEAMHEAMNNDVVMFVRVNDIEMELEGLKEEVEYLVENIEGNANYGEELVTAVEKVFL
What are the official names of this protein?
UPF0738 protein BCAH187_A1357.
What is the protein family that this protein belongs to?
Belongs to the UPF0738 family.
Protein: BRM_ARATH
Sequence: MQSGGSGGGPARNPAMGPAGRTASTSSAASPSSSSSSVQQQQQQQQQQQQQQQLASRQQQQQHRNSDTNENMFAYQPGGVQGMMGGGNFASSPGSMQMPQQSRNFFESPQQQQQQQQQGSSTQEGQQNFNPMQQAYIQFAMQAQHQKAQQQARMGMVGSSSVGKDQDARMGMLNMQDLNPSSQPQASSSKPSGDQFARGERQTESSSQQRNETKSHPQQQVGTGQLMPGNMIRPMQAPQAQQLVNNMGNNQLAFAQQWQAMQAWARERNIDLSHPANASQMAHILQARMAAQQKAGEGNVASQSPSIPISSQPASSSVVPGENSPHANSASDISGQSGSAKARHALSTGSFASTSSPRMVNPAMNPFSGQGRENPMYPRHLVQPTNGMPSGNPLQTSANETPVLDQNASTKKSLGPAEHLQMQQPRQLNTPTPNLVAPSDTGPLSNSSLQSGQGTQQAQQRSGFTKQQLHVLKAQILAFRRLKKGEGSLPPELLQAISPPPLELQTQRQISPAIGKVQDRSSDKTGEDQARSLECGKESQAAASSNGPIFSKEEDNVGDTEVALTTGHSQLFQNLGKEATSTDVATKEEQQTDVFPVKSDQGADSSTQKNPRSDSTADKGKAVASDGSQSKVPPQANSPQPPKDTASARKYYGPLFDFPFFTRKLDSYGSATANANNNLTLAYDIKDLICEEGAEFLSKKRTDSLKKINGLLAKNLERKRIRPDLVLRLQIEEKKLRLSDLQSRVREEVDRQQQEIMSMPDRPYRKFVRLCERQRLEMNRQVLANQKAVREKQLKTIFQWRKKLLEAHWAIRDARTARNRGVAKYHEKMLREFSKRKDDGRNKRMEALKNNDVERYREMLLEQQTNMPGDAAERYAVLSSFLTQTEDYLHKLGGKITATKNQQEVEEAANAAAVAARLQGLSEEEVRAAATCAREEVVIRNRFTEMNAPKENSSVNKYYTLAHAVNEVVVRQPSMLQAGTLRDYQLVGLQWMLSLYNNKLNGILADEMGLGKTVQVMALIAYLMEFKGNYGPHLIIVPNAVLVNWKSELHTWLPSVSCIYYVGTKDQRSKLFSQEVCAMKFNVLVTTYEFIMYDRSKLSKVDWKYIIIDEAQRMKDRESVLARDLDRYRCQRRLLLTGTPLQNDLKELWSLLNLLLPDVFDNRKAFHDWFAQPFQKEGPAHNIEDDWLETEKKVIVIHRLHQILEPFMLRRRVEDVEGSLPAKVSVVLRCRMSAIQSAVYDWIKATGTLRVDPDDEKLRAQKNPIYQAKIYRTLNNRCMELRKACNHPLLNYPYFNDFSKDFLVRSCGKLWILDRILIKLQRTGHRVLLFSTMTKLLDILEEYLQWRRLVYRRIDGTTSLEDRESAIVDFNDPDTDCFIFLLSIRAAGRGLNLQTADTVVIYDPDPNPKNEEQAVARAHRIGQTREVKVIYMEAVVEKLSSHQKEDELRSGGSVDLEDDMAGKDRYIGSIEGLIRNNIQQYKIDMADEVINAGRFDQRTTHEERRMTLETLLHDEERYQETVHDVPSLHEVNRMIARSEEEVELFDQMDEEFDWTEEMTNHEQVPKWLRASTREVNATVADLSKKPSKNMLSSSNLIVQPGGPGGERKRGRPKSKKINYKEIEDDIAGYSEESSEERNIDSGNEEEGDIRQFDDDELTGALGDHQTNKGEFDGENPVCGYDYPPGSGSYKKNPPRDDAGSSGSSPESHRSKEMASPVSSQKFGSLSALDTRPGSVSKRLLDDLEEGEIAASGDSHIDLQRSGSWAHDRDEGDEEQVLQPTIKRKRSIRLRPRQTAERVDGSEMPAAQPLQVDRSYRSKLRTVVDSHSSRQDQSDSSSRLRSVPAKKVASTSKLHVSSPKSGRLNATQLTVEDNAEASRETWDGTSPISSSNAGARMSHIIQKRCKIVISKLQRRIDKEGQQIVPMLTNLWKRIQNGYAAGGVNNLLELREIDHRVERLEYAGVMELASDVQLMLRGAMQFYGFSHEVRSEAKKVHNLFFDLLKMSFPDTDFREARNALSFSGSAPTLVSTPTPRGAGISQGKRQKLVNEPETEPSSPQRSQQRENSRIRVQIPQKETKLGGTTSHTDESPILAHPGELVICKKKRKDREKSGPKTRTGGSSSPVSPPPAMIGRGLRSPVSGGVPRETRLAQQQRWPNQPTHPNNSGAAGDSVGWANPVKRLRTDSGKRRPSHL
What is the function of this protein?
ATPase subunit of a multiprotein complex equivalent of the SWI/SNF complex that acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA.  Represses embryonic genes in leaves and controls shoot development and flowering.  Activates flower homeotic genes.  The association of BRM with its target genes requires REF6 (PubMed:27111034).  Necessary to acquire heat stress (HS) memory, by globally binding to HS memory genes (PubMed:27680998).
What are the official names of this protein?
ATP-dependent helicase BRM, Protein BRAHMA, AtBRM, Protein CHROMATIN REMODELING 2, AtCHR2.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH10_CAMJ8
Sequence: MNFQPLGKRVLVKRVEETKTTASGIIIPDNAKEKPLMGEVVAVSKEITDIANGDKIVFAKYGGTEIKLDNNEYLVLNLDDILGILK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGB_TREDE
Sequence: MRLIIKNSYEDCSKWTADYICNKIIEFKPTKEKPFVLGLPTGSTPLGVYKELIKKHKEGILSFKHVVTFNMDEYVGLEASHPQSYHYFMMDNFFNHIDIEPKNIHILDGMAKDKKKECEDYEKAIRSYGKIHLFLGGIGADGHIAFNEPYSSLTSRTREKTLTRDTIIMNSRFFEGNEDLVPKTALTVGIGTIMDAEEVLIMATGHAKAEAVHQAVEGGVSHVWTVSALQLHPKSIIICDDAATDELKVKTVKYFLDIEKGNIETNVSRK
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: BZPQ_DICDI
Sequence: MEEFENFFSQLIPAPDQDIWLLAAQQTPQNNDGVSTSGIPIGWSLQNLAASTNNIAAIDSNPQIREQLQQLQQQQQQQQTQIQQQLQSYQQQQQQHYQQRQQQYQQQYQQPYTTPSPPDQIDYNQQLSPQQQQQQQQQQQQQQQQQQQQPQLQQQNNTISQQQQQQNLNFQVQFLQQQQQHQQQLQQQQEQFQHQQLQHQQQQYFIKQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQHLSPILSPLPPIQQLQQYQQQQQQQQQQQQQQQQQQQQQQPQQQSINIGSSNTPLQHQAMLQAQSLMDSINTKQPPIPPTLQSPTQHQFLNTPVLDQHILSSIRPSYSQVTKANISTLPTEITNSLTNFNGTNNSTPNFEDLTGGKLSSNNIKNTATPLSSPPSTKNGKQKQPKNNNNNNNSSNNNNNNNQTTTQQKQSKNNNSYGNNSNNNNNNNNFNNNKLKKQNDSTTTPTITSPNMTSPIDSNGDFDLLDEDEKKKSISRINQNLASRNYRQRRKEYIKEIESKMAALTFENHQLKKENESLKETGGVEVMRPEPELITMVVEGKQIIIQLSQALKKNDDRSLIYLLHLYHCAIAKRYSIVEREVEKIVHPYTQSKLAAMGYIPKSDKMFLNCIAGPAADSWFQLFKNEAEITLEQSNKLEALRTQHGKIDSALLQERQELDLDIKKFYYTKILVLPNNPLIIGDIPAQPYNGELSQSPISNSPLEISQLLDFAGKLESLKKNFILHRNLMLDTLASLSSILTPRQEAMLLVRVHFYTSYDFSHMELLKDVWTNIVSSKSITGPLNISEALKKLSDTTNTHHSIENIVKPPQFHQYTPKQLKFENQSNNFGNNNGSKSKNIENNLNNSVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNSNNNNNVNSNSSNVNSNNNNFNNAPQMVLNPPSADAIPYPSTTQLDKRFQWVSYPSAPPPN
What is the function of this protein?
Probable transcriptional regulator.
What are the official names of this protein?
Probable basic-leucine zipper transcription factor Q.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEMTB_CAMJ8
Sequence: MTYNEKIISMNNDLLDHQHKELFEISKKLSLMNQRHVGTKELKIVLRELLIMINRHFSDEEAFMREIEYPYINHHTRIHRKIILEIEEIIISEAKFVNIMTEKLNLVVQDFIFKHTAKEDSKIVKYYEEKFKK
What is the function of this protein?
Oxygen-binding protein.  May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes.  The oxygen-binding site contains two iron atoms.
What are the official names of this protein?
Bacteriohemerythrin.
What is the protein family that this protein belongs to?
Belongs to the hemerythrin family.
Protein: TRMFO_LACGA
Sequence: MVKNVTVIGGGLAGSEAAWQLAKRGIEVELYEMRPKKTTPAHETANFAELVCTNSMRSNQLSNAVGLLKEEMRQLDSLIMKAADETAVPAGGALAVDRDKFSSVVTQTLKDLPNVHVHEEEITKIPKDGITIIATGPLTSDTLAEQIKDFCGTDSLHFFDAAAPIVAASSIDRDIVYKKSRYDKGEAAYLNCPMTKEEFFNFYKNLVSAETATLHGFEDKNVFEGCMPIEVMAKRGEKTMLFGPLKPVGLEDPKTGKTPYAVVQLRQDNAASTMYNIVGFQTHLKYGEQKRVFSMIPGLENAKFVRYGKMHRNTYIASPEVLNANYEARKQAGLFFAGQMTGVEGYVESAGSGLIAGINAARETVGEETLVFPKSTALGSMAHYITTTSAKHFQPMNASYALLPKLDYKVRNKQERHLEISKRALKDLETFKEEKKLD
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2C31_ORYSJ
Sequence: MGNGITKNPCFSGDPYAAAVASDPLPDDSHGHSFTYVPSSAAAFDHSPRSAAASSETSYFSLSGAAISANPATSASMPSFRLYNELTWPPSTACTFESSRSFAAAPLIQAAPPRLSMSGPLHATSGRFSEASGSASTASDRFSDHPFMDGMLDRASSASSTARLMPSFSHLMSEPRVAQSGLSNERSLIRSLVRVASKLRFGVPLSGRRSNGPAEPTTKSDGDYRSTPKGNVEWAQGMAGEDRFHVAVSEEHGWVFVGIYDGFNGPDATDYLFANLYVAVHRELKGVLWDDIQGVDVVTDNLPDPALANATHLCFLDAGGVGGGGDDDPDAERKAKRGRIERNADDDGASSVHRDVLKALARALARTEEAFFAAAEERAAQSPELGLVGSCVLVMLMKGKDVYLMNVGDSRAVLARRREPDFKDIFFRPDQDLQLLKAEVMRELEAHDRNGLQCVQLTPEHSAAAEEEVRRIRSQHLTDRQAVVNGRVKGKLSVTRAFGAGYLKQPKWNDRLLEAFKVDYIGAEPYISCTPSLRHHRISSNDRFLVLSSDGLYQYFTNKEVVDQVAMFTAEQPDGDPAKHLVGELVLRAARKAGMDCRRLLEIPHGDRRNYHDDVSIIVMSFEGRIWRSSV
What are the official names of this protein?
Probable protein phosphatase 2C 31, OsPP2C31.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: HIS4_ACIB3
Sequence: MLIIPAIDLKDGKCVRLKQGRMEDDTVFSDDPVATAQHWVNEGARRLHLVDLNGAFAGTPIHKPVVEAIAKAQPELPIQIGGGIRSLETIEHYLEAGVTFVIIGTKAVQEPEFVEEACKRFAGHIIVGIDAMNGMVATDGWANVTDVKATDLAKRFADAGVSSIVYTDIARDGMMQGVNVEQTVNLAQYSGLPVIASGGVTNLDDVRNLKGQPGILGAITGRAIYEGTLNLREAQLLLDENRL
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYL1_KLULA
Sequence: MSKPVLKASDITDELRDEIFELSSNATANYKLEREIAAYIKKQLDVSQGETWHVIVGKNFGSYVTHEKGYFVYFYIGPLAFLVFKTA
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).  Also a component of the nuclear pore complex (By similarity).
What are the official names of this protein?
Dynein light chain 1, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus, nuclear pore complex.
Protein: PSPC1_BOVIN
Sequence: MMLRGNLKQVRIEKNPARLRALESAAGEGDPAALALALPGEPPVPAAPAGEDRPADEGGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEDDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGNQGPPAMMGMNMNNRGTIPGPPMGPGPAMGPEGAANMGTPMMPDNGAVHNDRFPQGPPSQMGSPMGSRTGSETPQAPMSGVGPVSGGPGGFGRGSQGANFEGPNKRRRY
What is the function of this protein?
Together with NONO, required for the formation of nuclear paraspeckles.  Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line.  Binds to poly(A), poly(G) and poly(U) RNA homopolymers.  Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.  Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
What are the official names of this protein?
Paraspeckle component 1.
What is the protein family that this protein belongs to?
Belongs to the PSPC family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Nucleus matrix. Nucleus speckle. Note=In punctate subnuclear structures localized adjacent to nuclear splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA- dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps (By similarity).
Protein: SPE4A_MOUSE
Sequence: MGEGTPGVDSARVQEEGGRDQSLGFVEGRIQVGRIVTAGQLSLCSEEQSPQPGITRPSPGVVVDGESSGLAEPRVEATPQPPSSIQKRKRDESLDSEDDLAELFEPDPQPVWSVEMLCGLRMRLKRRRVSTVRPEHHKVFTKLLEDPVVKKFLTWDKMLRVSDKYLLSMVIAYFSRAGLFSWQYRPIHFFLALYLANDMEEDNQAPKQDIFYFLYGKSYAQRPMFHKLRFQFIRSMGWKIWVSREECEEIQAYNPDLWVWARDRTNLT
What is the function of this protein?
Promotes progression through the cell cycle via binding and activation of CDK1.
What are the official names of this protein?
Speedy protein E4A, Rapid inducer of G2/M progression in oocytes E4A, RINGO E4A, mSpy/Ringo E4A.
What is the protein family that this protein belongs to?
Belongs to the Speedy/Ringo family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURG_STRS7
Sequence: MTKKIIFTGGGTAGHVTLNLILIPKFIKDGWEVHYIGDDNGIEHQEIKKSGLDVAFHTIATGKLRRYFSWQNLLDIFKVGFGVMQSLFIIARLRPKALFSKGGFVSVPPVIAARLLGVPAFIHESDLSMGLANRIAYRFATTMYTTFEQEQTLVKLKHVGAVTKVTAPKSHSVASKQLAAVLEYFDPNLKTLLFIGGSAGARVFNRFITDHPELKEDFNIINISGDPSLNELSRHLYRVDYVTDLYQPLMEMADLVVTRGGSNTLFELLAMRKLQLIIPLGKEASRGDQLENAHYFTTRGYAEQLLEQELTLPHFQEKVREVFAKQSDYLSAMTSSSELQSPESFYQLLSADISSATKEN
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS20_RHIEC
Sequence: MANTTSAKKATRKIARRTDVNKARRSRVRTFVRQVEEAIASGDADKAKAAFLAAQPELARAASKGVLHSNTASRKVSRLAARVKALSVSPTA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RS19_LACLA
Sequence: MGRSLKKGPFVDEHLMKKVEAQVNAERKSVIKTWSRRSTIFPNFVGLTIAVYDGRKHVPVYVQEDMVGHKLGEFAPTRTYRGHAADDKKTRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: THIG_NITEC
Sequence: MDTLVIAGKSYTSRLLLGTGKYKDFTETRAAVDVSGTQIITVAIRRTNIGQNPDEPNLLDVLPPSQFTLLPNTAGCYTAADAVRTLRLARELLDGHALVKLEVLGDQKTLFPDVVATLEAARILVKDGFHVMVYTSDDPIVARQLEDIGCAAIMPLASLIGSGMGILNPWNLQIIIDKVKVPVIVDAGVGTASDAAIAMELGCDGVLMNTAVASARNPILMASAMRKAVEAGREAWLAGRMPKKIYQATPSSPSEGMITGSPHSAANN
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSPG_SHIDS
Sequence: MKITSTIIQTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESESLFPIDFRNIYAEYYAATKKDKEIIDRRLQMRTNDFYSLLNRKYL
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  This protein is a kinase that is involved in down-regulation of the host innate response induced by invasive bacteria (By similarity).
What are the official names of this protein?
Protein kinase OspG, Effector protein OspG.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Secreted. Host cell. Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cell.
Protein: MSHA_CORU7
Sequence: MRIAMISMHTSPLEQAGTGDAGGMNVYIRNTAEQLAKLGLSVDIFTRATRPLQGEVVELGDGVRVINCVAGPYEGLSKEELPTQLAAFTGSVLAFTRQHGLSYDLIHSHYWLSGQVAWLLRDLWNIRWVHTPHTLAAVKNNYLSEGDHREPESRRICEQQIVDNADVLIVNTDAEVADVEEGYDSHKARIAVVTPGADIEKFTPGTERATENARRALGIPLSAKVIGFVGRLQRLKGPHVLLQAAATLIERYPDMPIRVLICGGPSGSGLERPKCLEELAEELGISRAVRFLKPRPPEELVSIYQAADVVAMPSANESFGLVALEAQATGTPVVATRIGGLQAAVAEGKSGLLVDGQDPQAWADALGQLLSDDDQRIAMAEYAPQHAARYSWENTAKQLVELYRSLPTMPEEGPAERHPAGSAN
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.