PharMolix/UniProtQA huggingface dataset:
Protein: HRD1_YEAST
Sequence: MVPENRRKQLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQHI
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC1 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation.  Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD).  Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).  In ERAD-L, facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with DER1 (PubMed:32327568).  Both proteins have lateral gates facing each other which form a channel through the ER membrane and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568).  Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1.  ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1.  Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome.  ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M.
What are the official names of this protein?
ERAD-associated E3 ubiquitin-protein ligase HRD1, HMG-CoA reductase degradation protein 1, RING-type E3 ubiquitin transferase HRD1.
What is the protein family that this protein belongs to?
Belongs to the HRD1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PAM17_NEUCR
Sequence: MLSSTATTMLRAGVSRSSGALQPMLLRSAACPCSPFSMNTKLSQPTSVRPLSTSPSALVLRFRAQQQAQLAQQQLRRASSSSSSSSSSTRPRSDAELDANAAEAAAAAQSAAHAGEPVLDWNTFFKLRKTRRRVQLAFSVIMTLITSGAGGAVLSTGVADAMVAQVPLEPMFAVGLMTASFGALGWLMGPAMGGMVFNALKSKYRGQMEIKEGQFFARIKKHRVDPSASSMGNPVPDFYGEKISSVAGYRQWLKDQRAFNKKRTTFV
What is the function of this protein?
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
What are the official names of this protein?
Presequence translocated-associated motor subunit pam17, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PAM17 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL38_AEDAE
Sequence: MPQEIKEVKDFLIKARRKDARAVKIKKNENNTKFKIRCSRYLYTLVVQDKEKAEKLKQSLPPGLQVKEVK
What are the official names of this protein?
60S ribosomal protein L38.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL38 family.
Protein: ISTB_BURM1
Sequence: MLMQHTLTQLKALKLDGMARAFEEQSTLTASTSLSFEERVGMLVDRELAWRDTRRLERLLRAAKLKNPQACVEDIEYRQTRGLDQRIVATLAGCDWVRNAQNLILTGPTGAGKTWLACAFGQQACRQGFSVFYVRVARLFEELKIAHGDGSFTRRLAQLAKIDVLILDDWGLQDLDQAARNDLLEVLDDRVGTRSTVITSQLPLEHWHAWLQDPTLADAILDRLVHQAHKLPVKGDSMRKKTKSESADA
What are the official names of this protein?
Insertion sequence IS408 putative ATP-binding protein, ORF2.
What is the protein family that this protein belongs to?
Belongs to the IS21/IS1162 putative ATP-binding protein family.
Protein: LACA_STRZT
Sequence: MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTLAVAAEVNKEEQNLGIVIDAYGAGPFIVATKIKGMVAAEVSDERSAYMTRSHNNSRMITMGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacA.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: ACSA_MOUSE
Sequence: MGLPEERRKSGSGSRAREETGAEGRVRGWSPPPEVRRSAHVPSLQRYRELHRRSVEEPREFWGNIAKEFYWKTACPGPFLQYNFDVTKGKIFTEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTKITYRELLVQVCQFSNVLRKQGIQKGDRVAIYMPMILELVVAMLACARLGALHSIVFAGFSAESLCERILDSSCCLLITTDAFYRGEKLVNLKELADESLEKCREKGFPVRCCIVVKHLGRAELGMNDSPSQSPPVKRPCPDVQICWNEGVDLWWHELMQQAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTIGGYMLYVATTFKYVFDFHPEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDEGRLWSIVDKYKVTKFYTAPTAIRMLMKFGDDPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGSQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSASFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHTRFETTYFKKFPGYYVTGDGCRRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPTLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDTSTVADPSVINHLFSHRCLTTQ
What is the function of this protein?
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:11150295, PubMed:16790548).  Acetate is the preferred substrate but can also utilize propionate with a much lower affinity (PubMed:11150295).
What are the official names of this protein?
Acetyl-coenzyme A synthetase, cytoplasmic, Acetate--CoA ligase, Acetyl-CoA synthetase, ACS, AceCS, Acetyl-CoA synthetase 1, AceCS1, Acyl-CoA synthetase short-chain family member 2, Acyl-activating enzyme, Propionate--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RL34_STAES
Sequence: MVKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PYRG_NEUCR
Sequence: MKFVLVSGGVVSGVGKGIIASSCGLLLKTLGLKVTAIKIDPYINVDAGTMNPKEHGECFVLHDGGETDLDLGNYERYLGVDLARDNNITTGKVYQQVIENERKGKYLGRTVQVVPHVIDAIIDTINRVSRVPVDKSGEEPDVCIIELGGTVGDIESMPFVEALTQLRHRAGKNNFINIHVSYVPVVNGEQKTKPTQHAVKSVRSAGLIPDLIACRCEKPLEQGTINKVASSCQVEVNQVLAVRDMPTIYQVPLLLEEQGLLRELKETLKLDDVKLSPARVSQGQEVWAKWQKIVPLGYAETVDIVLVGKYVELHDAYLSVIKALEHSAMRCGRKLNLIWVDSEHLEEKTQKEDPTKYHKAWHDVCVAKGILVPGGFGHRGTEGMIRAAQWAREQKTPFLGVCLGMQVAVIEAARNLCELKDATSEEFDANAEHRVIIFMPEGSKEKLGGTMRLGTRSTHFQPGSEFSKLRALYGEATTIEERHRHRYEVNPDYIEKLEQSGLIFIGKDDSGERMEVVEIKDHPYYVGVQYHPEYTSRVLDPSRPFLGFVAAAIGCLDQITKEILQDAGFANGSINGAHF
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
What are the official names of this protein?
CTP synthase, CTP synthetase, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: DLG1L_DANRE
Sequence: MSPSIKKLDCFSPMLCHCKVACTNSTISLMFGCKKYRHQDEDTGSPQEPSSPQFTDDTPGPELVQVAEKSLSQIENVHGFVAHSHISPMKVESLECIFDGPSPVVKEESPPSPSTPLSNPYPQSPVSVQANPPPVVVNTESLDSAPYVNGTEADFEYEEITLERGNSGLGFSIAGGTDNPHIGEDPSIFITKVIPGGAAAQDGRLRVNDVILRVNEVDVRDVTHSKAVEALKEAGSLVRLYVRRRKSASEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKLLAVNSSCLEEVTHEHAVTALKNTPDVVYLKVAKPNSVFMNDSFAPPDITNSYSQHMENHISPPSYLSQPLPPVHSGRFSPTPKTTVGDDDVTREPRKVVLHRGTTGLGFNIVGGEDGEGIFISFILAGGPADLCGELRKGDRLVSVNGIDLRGATHEQAAAALKNAGQTVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVVNASDDEWWQARQVTAQGEVEEMGVIPSKRRVEKKERARLKTVKFNSKSREKGDNPDDMLSKGQSGQEEYVLSYEPVSQQEVNYSRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVVSREQMERDIQEHKFIEAGQYNSHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQVAMLYPIGIFIKPKSVENIMEMNKRLTEEQGRKTYDRAMKLEQEFMEHFTAIVQGDTLEEIYDQVKQIIEEQSGPYIWVQSKEKL
What is the function of this protein?
May play a role in synapse assembly and function.
What are the official names of this protein?
Discs large homolog 1-like protein, Synapse-associated protein 97B, SAP-97B, SAP97B.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: Y2613_METAC
Sequence: MKTLLIFTLTLLCSGCLEDTAVTPINTINPDSVEYYGVAAANNAFAFDMYSKLVQLESREKNNILFSPYSVSAAMAICYEGTEGTAKEQISNVFYFPANNTVFKVRLKETNDKVYSGSDGYELENANAIWVQEEYPVKEEYIFNVKNYYRSEVTNLDFVEKPDESRDAINEWVEDKTDRKIKDIVPKGSITDDTRLILTNAIYFNGKWEHEFDKKMTSKKTFYPTKREEVSVDMMYISSNFNYSENLKAKIIELPYKGNDLSMYIVLPKGNNITEFENNFTVNEYTELKYNMESLGDVETSIPKFKFETKTELSDSLIEMGVADAFDLKLANFSGISEIRLLISRMIHQDFIDVQEEVTEAAASTTVFIGSVSSSKSKSREFKADLPFIFFIEDRRTDCILFMGKVEYPEYEGTGRFWSLPWNK
What are the official names of this protein?
Uncharacterized serpin-like protein MA_2613/MA_2612.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
Protein: RS21_TERTT
Sequence: MPSVKLKENEPFDFALRRFKRSCEKAGVLAEVRRREFYEKPTSVRKRKAAAAVKRHAKKVQRENRKFQRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: LPXA_RICTY
Sequence: MSNSNIHTTAIIAEGAKFGKNVKVGPYCIIGPEVVLHDNVELKSHVVIDGITEIGENTVIYPFASIGQPPQILKYANERSSTIIGSNNTIREYVTVQAGSKSGGMITRVGNNNLFMVGVHIGHDCKIGNNLVFANYVSLAGHIKVGDYAIIGGLSAVHQYTRIGEYSMIGGLSPVSADVIPFGLVSSKRAVLEGLNLIGMNRKGFDKVDSLTALNAVEEIFLGKGNFADRIKQVAEKYKNNSIVTQIIDFLNQDSSRSFCHFKK
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_CUPPJ
Sequence: MSHTMTPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDTIVRDLAEMAIKQTRESEMKKVRTKAEEAAEDRLLDVLLPPPRDIGFSQPEEKDSNTRQVFRKKLREGQLDDKDIELEVAAGLPSMDIMGPPGMEEMTEQIRSMFAGMGQGKKHRRKMKVKEAFKLLIDEEAAKLVNDEELKHKAIANVEQNGIVFLDEIDKIANRSELGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTDHILFIASGAFHLSKPSDLIPELQGRFPIRVELESLSVQDFEAILTQTDASLTKQYQALLKTEEVELQFAPDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLEDLSFHASKSSGETVTIDAAYVNERLGDLAVNEDLSRYVL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLO2_FRAT1
Sequence: MQIKRWFLNNSLRNYQYLLYDKSHAIVIDPLKSDIFAEFIAKNKLQLEAILITHKHGDHIAGVKKLLAIYLNAKVYAYTGNDLFKPDIYVKDGSFINLGFTSFRVMYIPGHIDDHVCFLFEQERALFCGDTLFNAGVGGVQAESADINQLYDSLVKITKLDGDIKPYPAHDYWLGNLDFALSILADDSYFNYYRNQVAELAAEDKPIVNLAEEAKLNIFIRAMSDKALLKALPDYSLGREMFVKLRQLKNNF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: VPK04_HUMAN
Sequence: WASQVSENRPVCKAIIQGKQFEGLVDTEADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGQDLLQQWGAEITMPAPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKVPVEAKINQKREGIGYPF
What is the function of this protein?
Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle.  Endogenous Pro proteins may have kept, lost or modified their original function during evolution (By similarity).
What are the official names of this protein?
Endogenous retrovirus group K member 104 Pro protein, HERV-K104 Pro protein, HERV-K_5q13.3 provirus ancestral Pro protein, Protease, Proteinase, PR.
What is the protein family that this protein belongs to?
Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.
Protein: PYRE_RUEPO
Sequence: MIPAAYPTREEIARLTARMLLEIGAVNFNTKEPYILASGLPSPSYIDCRKLISFPRIRSTLMDFLTVTVMRNAGFEAFDNIAGGETAGIPFAALVAERMALPMTYVRKKPKGYGRNARIEGAMSEGQRVLLVEDLTTDGGSKLSFVDAIRETGASCGHTAVIFYYDIFPETEKTLGDHGVALHYLCTWWDVLAEARAQKAFDEVTLSGVEAFLKDPRAWQAANKR
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: TRXH_CHLRE
Sequence: MGGSVIVIDSKAAWDAQLAKGKEEHKPIVVDFTATWCGPCKMIAPLFETLSNDYAGKVIFLKVDVDAVAAVAEAAGITAMPTFHVYKDGVKADDLVGASQDKLKALVAKHAAA
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide.  The H form is known to activate a number of cytosolic enzymes.
What are the official names of this protein?
Thioredoxin H-type, Trx-H, Thioredoxin-CH1.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant H-type subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_COXBN
Sequence: MAKKITGYIRLQIKAGEANPSPPVGPALGQHGVNIREFCESFNTATKNIEKGLPTPVIITVYADRTFSFITKTPPASILLKKFVLKGKSGSARPNTEKVGKATRQQLEEIAKMKTPDLTAADLEAAIRTIAGTARSMGIDVEGVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: TRPC6_MOUSE
Sequence: MSQSPRFVTRRGGSLKAAPGAGTRRNESQDYLLMDELGDDGYPQLPLPPYGYYPSFRGNENRLTHRRQTILREKGRRLANRGPAYMFNDHSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAILNGDAETRQPGDFGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEEKKFGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHLNSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRKLGERLSLEPKLEESRR
What is the function of this protein?
Thought to form a receptor-activated non-selective calcium permeant cation channel.  Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.  Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C.  Seems not to be activated by intracellular calcium store depletion.
What are the official names of this protein?
Short transient receptor potential channel 6, TrpC6, Calcium entry channel, Transient receptor protein 6, TRP-6.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARGOS_ARATH
Sequence: MIREISNLQKDIINIQDSYSNNRVMDVGRNNRKNMSFRSSPEKSKQELRRSFSAQKRMMIPANYFSLESLFLLVGLTASLLILPLVLPPLPPPPFMLLLVPIGIMVLLVVLAFMPSSHSNANTDVTCNFM
What is the function of this protein?
Promotes cell proliferation-dependent organ growth.  Takes part in the AXR1-dependent auxin signaling pathway that requires ANT during organogenesis.
What are the official names of this protein?
Protein AUXIN-REGULATED GENE INVOLVED IN ORGAN SIZE, AtARGOS.
What is the protein family that this protein belongs to?
Belongs to the plant organ size related (OSR) protein family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum.
Protein: YQGF_AERHH
Sequence: MSSRSIMGFDYGTKSIGVAIGQELTGTAQPLRAIKANDGIPNWDDIDKLLKEWQPDLLVVGLPLNMDGTEQEITVRARKFGNRLHGRFGKQVEFKDERLTTTDARARLFERGGYRALEKGSVDGVSAQLILEAWMEEQYG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP33A_CAEEL
Sequence: MAANEDRDDAAAILNWEGTSEIKSANEYSRNLLFSVLDSLDGNKTIVWDRDRSVMHRVNLFAGASVLAAHGVVANHSIETKKSASTPHVVFFLAPTMVSLDLLCDYIDNVRNDSKILYQVFFIPEAWFVVRESLKTRAEGKYWERLESVKEIPLCWLPRDGECLSLSSPQIAARLLINGDWTHLHKCAVALNQLIDMCRGRSSSSNQRPMSIYAKGKWASDVAKMMGKIRNSAEADSMTKNLDPIEGLLKINRIVLIDRWMDPLTPMLSQLTFYGLLDEIYGIGMVNSVKVPEMEFKNEKDGDPFQEKEVYLIDEVYHRLKHSHINAVSIEASKVLAEIRDDEQFDRDKMSVAEYSVLVKKMPKIINRKKMIEVHMRLAEMIQSHVYCKQSDSIKLERDLLEYSDSDKAIPLIEDLIFDASPLNAVLRLISVHSLTCGGLKPSVLQHYRRIVNQSYGSSALNKVLKMQKMGLIREKGGGGKMQCEYAQMMFQQMKKNHDMLPEEFSEAKLDDMAYAYSGFSPLLCKMLEEGDRVKWVGWPKTVIGDKSDLIAERDGRGTCVFVIGGLTRSELAIIRENLPNVALITTSALITGDKLLNNITNI
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:25273556, PubMed:26783301, PubMed:27558849).  Believed to act as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556).  The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity).  Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells (PubMed:24501423, PubMed:25273556).  Required for endosome/lysosome fusion (PubMed:26783301, PubMed:27558849).  Required for early embryonic development (PubMed:27558849).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 33A, Protein slp-1.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
What are the subcellular locations of this protein?
Lysosome. Early endosome. Late endosome. Apical cell membrane; Peripheral membrane protein. Note=Localizes to lysosome-related gut granules.
Protein: RL20_AZOC5
Sequence: MARVKRGVTSHAKHKKVFKAAKGFYGRRKNTIRAAKSAVERSMQYNYRDRKVKKRTFRALWIQRINAGVRELGMTYGRFIDGLGKAGIEVDRKVLSDIAVHEPETLKALVEKAQAALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: SODF_AQUPY
Sequence: MGVHKLEPKDHLKPQNLEGISNEQIEPHFEAHYKGYVAKYNEIQEKLADQNFADRSKANQNYSEYRELKVEETFNYMGVVLHELYFGMLTPGGKGEPSEALKKKIEEDIGGLDACTNELKAAAMAFRGWAILGLDIFSGRLVVNGLDAHNVYNLTGLIPLIVIDTYEHAYYVDYKNKRPPYIDAFFKNINWDVVNERFEKAMKAYEALKDFIK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Fe], Fe-SOD.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: ARMH3_ARMME
Sequence: MEAQVPLSTDILVIGGGPAGSYAAAVLAREGFKVVLLEKDVFPRYHIGESMLPSCRPFLRFIDFEEKMKNYGFFPKPGAALKLNQDKREGYTDFTANGPDNAAWNVVRSEFDDLLLRHAAELGVHVYEGVQVEKIHFSPDESTRPVSLAWSKGDGTQGDVSFNWLVDASGRNGIMSTRYLKNRTFNKSLKNVAVWGYWTGAGRYAPGTKRENAPWFEALTDETGWAWFIPLHNGATSVGVVLAEDESKRKKAQHRAESNGKSLSEVQHDCYMADLQRAPGLIQLLGSEAKFEGKLMSAGDYSYHASEYAGSHFRIAGDAGAFIDPFFSSGIHLALTGGLSAASTIAASIRGNCTEEEACAFHSSKVETAYTRFLFVVLGIYKQIRAQETAVLYEAEEDNFDRAIDSLRPVIQGCADADENLTEAELQSTLDFCRSVLAPNQQQNNLRTPVDTGAADVKAKHAPSETDAQNPLQSMDDCKRNFGTEVINGFYVKMEQGMLGLVCA
What is the function of this protein?
Flavin-dependent halogenase involved in the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols.  The halogenase catalyzes the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product.  The enzyme acts on free substrate and does not depend on carrier-protein-dependent acceptor molecules.
What are the official names of this protein?
Flavin-dependent halogenase armH3.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: RPOA_RICBR
Sequence: MLSLSKNWNALIKTDKVSYESFPETNNKSKIIVEPLERGFGLTLGNAMRRVLLSSLQGAAVTSIKIPGIEHEFSSIPGVKEDISEIILNVKGIEIKMHVAEKRVIRLKATGPGAITAGMIEAGHDVEILNPDHVICNLAKNKQFEMELTCKVGKGYTLSTNNNEDNNLPIGEIAIDALFNPVKSVTYKVENTRIGQVTDYDKLIMFVETNGDILPEMAVGLAARILQEQLQLFISFEEQEEDKQVKTDALPFSPYLLKRVDELELSVRSANCLKNDNIIYIGDLVKRTEADMLRTPNFGRKSLNEIKEILAKFSLRFGMDVPDWPPENIHELSKRYEDSYN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: GATE_SACS2
Sequence: MSELNYEELGLKVGLEIHQQLNTPHKLFCNCSTNLEEEYKLTLERYLRPALSELGEVDVAALFEWKKGKKYVYRIPITTSCLVEADEEPPHAINEEALKIALAIAMALNSNIVDEIYVMRKIVIDGSNTTGFQRTAIIALGGMLKDEEVSIQSIAVEEDAARKIDEGTDQVTYSLDRLGIPLIEISTGPDIRSPEQAERVALKIGQLLRMTGKVKRGIGTIRQDLNISIKGGTKIEIKGVQKLELIPDIVRYEAIRQFNLLKIKEELYRRGLTKELVLSNFVVKDVTELFKNTNSKIIKNGIEKGGLVYGIRAYKLKGVLGWELIPKKRRFGTEIADYVRALAGLGGLFHSDELPNYGITEEEINKVREALNATTEDALILIVGERERLDKAVEVIKDRILLAFDGIPKETRGALDDGTTKFLRPQPGSARMYPETDIPPRRIDEKLLEDAKKLVPESPESKMKRYIVLGLSEELAKEIIRDPRLDLFEELVNKYSPRVPPVVIASTITNTLKYVKSKGGDISKINEEDIEELIKSIYESRISKDSISEILVEYTTSKNVELKDIIRKYEVLPIEELEKIIDDIINSNLDEIRKRKDKAVNLIMSKVMSKVKGRADGKIVLELIRSRLKNVIE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit E, Glu-ADT subunit E.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatE subfamily.