PharMolix/UniProtQA huggingface dataset:
Protein: SIRN_LEPMC
Sequence: MTVETKDLPESNYLLDYDDTEKRRLREQHDLIKAYTGKLILAPLDLTKPNLKILDSGTFDGHWLTEAAKPLTTPLLTGTDISPAAFPNPPPQNTSFHIQSITDPWPASWQNTFDLVHQRLVLAGTTPTGGLDAVRNLAGLAKPGGWVQLIEGKLLAESQRTRFPALHRFHSFIERMLPGFGWNIRAGLMVGGWLGEVGLEEVGEMEVEIPVGRANGDGRLGAMAEKNLRDVMGVWRQASSKLPADSPFKASELEEIFVDWDKEIETIGSLLRFAVVWGRRPALD
What is the function of this protein?
N-methyltransferase; part of the gene cluster that mediates the biosynthesis of sirodesmin PL, an epipolythiodioxopiperazine (ETP) characterized by a disulfide bridged cyclic dipeptide and that acts as a phytotoxin which is involved in the blackleg didease of canola (PubMed:15387811, PubMed:18272357, PubMed:19762440).  SirD catalyzes the O-prenylation of L-tyrosine (L-Tyr) in the presence of dimethylallyl diphosphate (DMAPP) to yield 4-O-dimethylallyl-L-Tyr, and therefore represents probably the first pathway-specific enzyme in the biosynthesis of sirodesmin PL (PubMed:19762440, PubMed:21038099, PubMed:24083562).  4-O-dimethylallyl-L-Tyr, then undergoes condensation with L-Ser in a reaction catalyzed by the non-ribosomal peptide synthase sirP to form the diketopiperazine (DKP) backbone (PubMed:18272357).  Further bishydroxylation of the DKP performed by the cytochrome P450 monooxygenase sirC leads to the production of the intermediate phomamide (PubMed:27390873).  This step is essential to form the reactive thiol group required for toxicity of sirodesmin PL (PubMed:27390873).  The next steps of sirodesmin biosynthesis are not well understood yet but some predictions could be made from intermediate compounds identification (PubMed:18272357).  Phomamide is converted into phomalizarine via oxidation, probably by sirT (PubMed:18272357).  Further oxidation, methylation (by sirM or sirN) and reduction steps convert phomalizarine to deacetyl sirodesmin (PubMed:18272357).  Finally, acetyltransferase sirH probably acetylates deacetyl sirodesmin to produce sirodesmin PL (PubMed:18272357).
What are the official names of this protein?
N-methyltransferase sirN, Sirodesmin biosynthesis protein N.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Protein: ATPD_HALHL
Sequence: MAERSTLARPYARAVFELAGDDATERQAWSRRLAAVAEVVQVPQLASLLTHPRISAEQLAGIVCEAAGDLGQTGENFVRLLASNRRLQYAPEVARVYEELRAEAEGIVDVEVLSATQLEDAQQERLAEALRKRLGREVRLQTRVDESLIGGAMIRAGDTTIDGSVKGKLARLSSALVH
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ZRAP_SALTI
Sequence: MKRNNKSAIALIALSLLALSSGAAFAGHHWGNNDGMWQQGGSPLTTEQQATAQKIYDDYYTQTSALRQQLISKRYEYNALLTASSPDTAKINAVAKEMESLGQKLDEQRVKRDVAMAQAGIPRGAGVGYGGCGGYGGGYHRGGGHMGMGNW
What is the function of this protein?
Binds zinc.  Could be an important component of the zinc-balancing mechanism (By similarity).
What are the official names of this protein?
Zinc resistance-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ZraP family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HBOH_AZOSB
Sequence: MNPSLCIAVAFACPLSALAASGAPGVGFNEKPSFLGEIVQRSVDGVSDDLLTAGLGRDGIQSATPPLVSASPTATELRRLAIYNNYRALVDTTSGGGFGSLFGPLIAVDAGGRVSAPGDGKIAGTEYLAYAIDRGDDSKVTLMVQVPAHFNPKAPCIVTGTSSGSRGIYGAIGTSGEWGLQKGCAVAYADKGTGNGMHDLDTNTVGLIDGTRADAVAAGVASHFTADLTEAERTQFLASWPHRVAVKHAHSRANPEAHWGQDTLDAVRFAFFVLNETYGRRTPRGIVRTILPPNTVVIASSVSNGGGAALAAAEQDDERLIDGVAVGEPQIQLRENDAVRVVRGSQVRTGTGRPLYDYTTFANLLQPCAVLSPRAAGSPGEAFIPAALAANRCEALAAHEFITGNTPAERGDSALDALVAYGWEPESTPLTASHYAFAVPPIALTYANAYGRFGVEERVCNYSFAATDAAGTPIAWPAASAATSFGTGNGIPPAAGLQIINDASLGGPRRDGASISPSTGKLDFNVDGALCLRQLWTGGGASAREVHESVDEVQVSAQLQGRPAIIVHGRADALVPVGFTSRPYLGLNSLAEHGRSRLRYVEVTNAQHFDAFIGTATLPGYDTRFVPLHVYFRQALDLMYSHLTARTPLPPSQLVRTTPRAGTPGAAVAITAANVPPIRMKPAAADLITVRRGEVVVPD
What is the function of this protein?
Participates in the degradation of poly-3-hydroxybutyrate (PHB).  It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.
What are the official names of this protein?
D-(-)-3-hydroxybutyrate oligomer hydrolase, 3HB-oligomer hydrolase, 3HBOH.
What is the protein family that this protein belongs to?
Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.
What are the subcellular locations of this protein?
Secreted.
Protein: LGT_BRUA1
Sequence: MIETLLPASALAFPAIDPVIFRVGPLAVHWYGLGYVVGILFAWWYGKKLLRSHRLWANNQPPMAPEALDDFVIWAALGVVLGGRIGYVLFYNFSYYISNPLAIPALWDGGMSFHGGILGTTLAMILFARSRGILVWSMFDTIAAGVPIGLGVVRVANFINSELWGRVSDVPWAVYFPNGGPLPRHPSQLYEAFLEGLVLFFVLFVLVWGARKLKQPGFVAGAFVTGYGLSRIAVEFFREPDAQIGYLFGGWLTMGMVLSVPMVLLGLWAMWRANRAAARNA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PRR9_BOVIN
Sequence: MSFNEQQCKQPCVPPPCLQKTQEQCQAKAEEVCLPPCQDPCQEKCPTKVQEVCVPQCQALSQDNCPQQSQDPCLPLCPDQCPSQCTEPCQELSQTKCVEVCPQKIQEKCLPPGKGK
What are the official names of this protein?
Proline-rich protein 9.
Protein: GUNF_FUSOX
Sequence: MHTLSVLLALAPVSALAQAPIWGQCGGNGWTGATTCASGLKCEKINDWYYQCVPGSGGSEPQPSSTQGGGTPQPTGGNSGGTGLDAKFKAKGKQYFGTEIDHYHLNNNPLINIVKAQFGQVTCENSMKWDAIEPSRNSFTFSNADKVVDFATQNGKLIRGHTLLWHSQLPQWVQNINDRSTLTAVIENHVKTMVTRYKGKILQWDVVNNEIFAEDGNLRDSVFSRVLGEDFVGIAFRAARAADPAAKLYINDYNLDKSDYAKVTRGMVAHVNKWIAAGIPIDGIGSQGHLAAPSGWNPASGVPAALRALAASDAKEIAITELDIAGASANDYLTVMNACLAVPKCVGITVWGVSDKDSWRPGDNPLLYDSNYQPKAAFNALANAL
What are the official names of this protein?
Putative endoglucanase type F, Cellulase, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
Protein: PUR5_SYNC1
Sequence: MSDQKKMTYKDAGVDIDAGNRFVQLIKPLVKATSRPEVLTDIGGFGGLFSLHADKYKKPTLVASTDGVGTKLKLAFMMDKHDTVGIDLVAMCVNDIVVQGAEPLFFLDYMATGKLTPEKAQDVVKGISEGCIQAGCALIGGETAEMPGFYGEGEYDLAGFTVGIVDNTSIIDGSGITVGDRLIGLASSGLHSNGYSLARKVLFEHLGLNADSKVEELDLSVGEELLKPTRIYVKTILNLLRDFQIKGMAHITGGGLVENVPRMMPKNCQAIIHKDSWPKPPIFELLRKAGNIEEEEMYRTLNYGIGMVLVVPETEAEEIMVRLSGLKEDAFIIGEIAKSAEEGEPTVTLI
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UGTP_STAS1
Sequence: MVTQNKKILIITGSFGNGHLQVTQSVVNQFKEMNLDNLTVIEHDLFLEAHPILTSICKKWYINSFKYFRNMYKAFYYSQPDQLDKCFYKYYGLNKLMNLLLKEKPDLILLTFPTPVMSVLTEQFDMNIPIATVMTDYRMQKNWITPFSQRYYLATEELKDEFASIGIPKDKLKVTGIPISDKFETDIDKTAWLSQNHLDPDKPTILMSAGAFGVSKGFGQMIQEILNRSPHAQVVMICGKNKDLKRSLTSQFKDFNNVLILGYTKHMNEWMASSQLMITKPGGITISEALTRQIPMIFLDPAPGQELENAVYFEEKGYGRIANTPEAAIEQVAALTNAPTKLASMSESMDASRIPYSTYKLCKDLLNLLNHSSHYEEVYGKVPLYAKLFVK
What is the function of this protein?
Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids.  Is able to successively transfer two glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol).  Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).
What are the official names of this protein?
Processive diacylglycerol beta-glucosyltransferase, Beta-diglucosyldiacylglycerol synthase, Beta-DGS, DGlcDAG synthase, Glc2-DAG synthase, Beta-gentiobiosyldiacylglycerol synthase, Beta-monoglucosyldiacylglycerol synthase, Beta-MGS, MGlcDAG synthase, Diglucosyl diacylglycerol synthase (1,6-linking), Glucosyl-beta-1,6-glucosyldiacylglycerol synthase, UDP glucosyltransferase, UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. UgtP subfamily.
What are the subcellular locations of this protein?
Cell membrane.
Protein: HIS7_RHOPB
Sequence: MRTATIKRKTKETAIEVTVDLDGTGASNIATGIGFFDHMLDLLARHSRIDITVKAVGDLHIDYHHTTEDVGIALGQAVKQALGNMAGITRYAGIHLPMDETLTRVVIDISGRPTLVFKAEFPRDKIGEFDTELVREWFNAFAMNAGVTLHVETLYGENSHHIAESCFKGLARVLRAAVAIDPSAAGEVPSTKGQLGG
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_LEPBL
Sequence: MAETQAPAGYLFSEKHEWVKVEGDTALIGISDFAQSALGDIVFVDLPKSGKTVKQFETFGTIESVKAAEDLYAPVGGEVIESNSALSKNPGDVNSKPFDSWMIKVKGFSTSELEKLLSPEKYKALVAKLE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: PB1F2_I56A1
Sequence: MEQEQDTPWTQSTEHINTQKGGSGQQTRKLERPNSTQLMDHYLRTMNQVDMHKQTASWKQWLSLKDPTQESLKIHVLKRWKLFNKQEWTN
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: Y2163_STRP8
Sequence: MLTFLIPTAKEMTTPKESHPHLLPQDSQAILKIMTAMTTEDLAKSYRIKEEAAKKEQQRWQDMASQQSLAYPAYQLFNGLMYRHIKRDKLTTQEQAYLTQQVYITSSFYGIIPANHPIAEHRHDFHTRIKIEGQSLKSYWRPCYNQFAKEHPQVISLLSSEFDDVFSKDCKQLWISPKFMAEKEGQFKTHSTISKKARGAFLTACMENNCQTVDSLKSLVFAGFYYHPDLSTDHEFVYIKKEA
What are the official names of this protein?
UPF0246 protein spyM18_2163.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: MAP2_UNCRE
Sequence: MAVQAPEVDKLSLNEESVAKAPTKGSAAQGTAGDEDAENEESDEDDDQGVAEGAVATGDKKKRKRKPKKKKKKGVAKVQSNPPRVPLSTLFPNSQYPEGDIVEYKDDNAYRTTNEEKRHLDRMNNDFLSDYRQAAEIHRQVRQYAQKELIKPGRSLTEIAEGIEDSVRALTGHMGLEEGDSLVAGMGFPTGLNINHCAAHYSPNAGNKMVLQHGDVMKVDFGVHVNGRIVDSAFTVAFDPVYDNLLEAVKDATNTGIREAGIDVRMSDIGAAIQEAMESYEVELNGTTYPVKAIRNLNGHTIGHYLIHGGSTGKSVPIVKGGDQTKMEEGETYAIETFGSTGKGYVRDDMEVSHYARVPDAPNVPLRLSSAKNLLNVITKNFGTLPFCRRYLDRLGQDKYLLGLNNLVSSGLVDAYPPLVDVKGSYTAQFEHTILLRPNVKEVITRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2, MAP 2, MetAP 2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAAH_CUPTR
Sequence: MKPVTTDLCDAHEDRLAEGTLRVMAPVFRAFGKQPAFAGPAATLKVFEDNSLVRATLESPGRGRVLVIDGGGSLRCALVGGNLGLLAEKNGWVGIVVNGCIRDTAELDVCDIGIRALAAHPQKSQKRNVGESEVTVQMPGAVVRPGNWIYVDVDGILVADDKLER
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: CCMA_AROAE
Sequence: MVKSTPMLYAADLACLKGDRLLFRGLSLHVAPGAMLRIAGPNGFGKTSLLRILCGLAHPEAGEIRWNGRPIAGDRESFHRTLLYLGHAPALNDLLTPLENLRFACAAAGDDVDEDACVDALVRIGLADQLDLPARVLSQGQRRRVGLARLFLGIRRSLWVLDEPFTALDAAAVADLATTLSDHCAAGGVVILTTHQDAPFAVPPTVLDLSEVAA
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TAA7A_MOUSE
Sequence: MDKLVDHFLSDQSRTMNEDLFSATSTELCYENLNRSCVRSPYSPGPRLILYAVFGFGAALAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSTVRSVEGCWYFGESYCKFHSCFEGSFCYSSIFHLCFISVDRYIAVSDPLTYPTRFTASVSGKCITFSWLLSIIYSFSLLYTGANEAGLEDLVSVLTCVGGCQIAVNQSWVFINFLLFLIPTLVMMTVYSKIFLIAKQQAQNIEKMSKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFITPTYVYEILVWIAYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSTTNLFPE
What is the function of this protein?
Orphan olfactory receptor specific for trace amines.
What are the official names of this protein?
Trace amine-associated receptor 7a, TaR-7a, Trace amine receptor 7a, mTaar7a.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IAP_ASFH8
Sequence: MFPKINTIDPYISLRLFEVKPKYVGYSSIDARNQSFAIHGIKNYEKFSNAGFFYTSPTEITCYCCGMKFCNWLYEKHPLQVHGFWSRNCGFMRATLGIIGLKKMIDSYNDYYNNEVFVKHKNRVYTHKRLEDMGFSKPFMRFILANAFIPPYRKYIHKIILNERYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL
What is the function of this protein?
Prevent apoptosis of host cell by inhibiting caspase-3/CASP3 activation to promote the viral replication.  Induces also the activation of host NF-kappaB.
What are the official names of this protein?
Inhibitor of apoptosis protein, IAP, IAP-like protein p27.
What is the protein family that this protein belongs to?
Belongs to the asfivirus IAP family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion. Note=Probably accumulates in the perinuclear cytoplasmic viral factories. Found in association with viral nucleoid.
Protein: NPT1_HUMAN
Sequence: MQMDNRLPPKKVPGFCSFRYGLSFLVHCCNVIITAQRACLNLTMVVMVNSTDPHGLPNTSTKKLLDNIKNPMYNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPCISISEKEYITSSLVQQVSSSRQSLPIKAILKSLPVWAISTGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTAAGFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAPRYFGFIKACSTLTGMIGGLIASTLTGLILKQDPESAWFKTFILMAAINVTGLIFYLIVATAEIQDWAKEKQHTRL
What is the function of this protein?
Important for the resorption of phosphate by the kidney (PubMed:7826357).  May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:7826357).  Plays a role in urate transport in the kidney (PubMed:27906618, PubMed:25252215).
What are the official names of this protein?
Sodium-dependent phosphate transport protein 1, Na(+)/PI cotransporter 1, Na/Pi-4, Renal Na(+)-dependent phosphate cotransporter 1, Renal sodium-dependent phosphate transport protein 1, Renal sodium-phosphate transport protein 1, Sodium/phosphate cotransporter 1, Solute carrier family 17 member 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: ILVD_DESVV
Sequence: MRSKKMTHGLEKAPHRSLLHALGLTREELARPLVGVVNAANEVVPGHIHLDDIAEAVKAGVRAAGGTPLEFPAIAVCDGLAMNHEGMRFSLPSRELIADSIEIMATAHPFDALVFIPNCDKSVPGMLMAMLRLDVPSVMVSGGPMLAGATLAGRADLITVFEGVGRVQRGDMTEAELDELVEGACPGCGSCAGMFTANSMNCLAETIGLALPGNGTTPAVTAARIRLAKHAGMKVMEMLERNIRPRDIVTEKAVANAVAVDMALGCSTNTVLHLPAVFAEAGLDLTLDIFDKVSRKTPNLCKLSPAGHHHIQDLHAAGGIPAVMAELDSIGLIDRSAMTVTGRTVGENLDALGAKVRDADVIRSVDAPYSPQGGIAILKGSLAPGGAVVKQSAVAPEMMVREAVARVFDSEEAACEAIMGGRIKAGDAIVIRYEGPKGGPGMREMLTPTSAIAGMGLGADVALITDGRFSGGTRGAAIGHVSPEAAEGGPIGLVQEGDRIRIDIPARALDLLVDEDELARRRAVFVPVEKEITSPLLRRYARMVSSAATGARQR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: MNMA_PSYA2
Sequence: MSAMPNTSSISVSAAFDAHRPLTLTYIDNPSTKHVIVGMSGGVDSSVSAVLLQQAGFVVEGLFMKNWEEDDGTEYCTAMDDLADAQAVCDKIGIKLHTANFAMEYWDRVFEHFLAEYKAGRTPNPDILCNKEIKFKAFLDYALTLGADYIATGHYTRRSVNYKNNDGIEVAQLLRGLDNNKDQSYFLHAVGGDKLAKTLFPVGELEKPVVRQIAEEHDLITANKKDSTGICFIGERRFKDFLQQYLPAQKGDIVTDDGINIGTHDGLMYYTLGQRGGIGIGGVKDRPEEPWFVLAKDLDNNRLIVGQGHEHPMMLSNELHAYKLDWTDGLPPTDIFSLEGLRCMAKSRYRQPDQACRVFAVNADGSEVRVIFDEPQRAVTPGQSAVFYIEEVCLGGGVIASIDAPCGF
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_LIMRD
Sequence: MIDVNKFESMQIGLASPDKIRSWSYGEVKKPETINYRTLKPEKQGLFDERIFGPTKDYECACGKYKRIRYKGRVCDRCGVEVTSAKVRRERMGHIELAAPVSHIWYFKGIPSRMGLVLDMSPRSLEEVIYFASYVVLDPGDTPLEKKQLLTEAEYRDKKAEYGDRFKAEMGAAAIQKLLADVDLEKEAAELKEELKEATGQKRTRAIRRLDILEAFIKSGNKPEWMVMDVIPVMPPDLRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLKLQAPGIIVQNEKRMLQEAVDALIDNGRRGRPVAGPGNRPLKSLSHLLKGKQGRFRQNLLGKRVDYSGRSVIDVGPSLKLNQMGLPVPMALELFKPFIMHELVKRGLSANVKSAKRKIDRSDDDVFDVLEDVIKEHPVLLNRAPTLHRLGIQAFEPILVSGKSMRLHPLVCSAYNADFDGDQMAIHVPLSDEAQAEARLLMLAAHHILSPRDGEPIVSPSQDMVIGNYYMTTEDKGREGEGMIFKDTDEAELAYRNDYVSLQTRVGVQVSAFPEKPFTDDQRGKIMVTTVGKLLFNRIMPKDFAYINEPTDANIQNGVDDRFFLEPGQDIHEYLENAPLVPPFKKGFLSDLIAEVYKRYKVTKTSQFLDRIKDLGYYESTISGLTTAMSDIHDLPEKPEILDKAQKQVTLITKQFRRGLITDDERYERVIGAWNDAKDEVQNKLIEHMDIHNPINMMSDSGARGNISNFTQLAGMRGLMASPNGKIMELPVKSNFYEGLSVLEMFISSHGARKGMTDTALKTANSGYLTRRLVDVAQDVVVREKDCGTDRGLEVTAITNGNEMIEPLYDRIMGRYTMKSVFDPKTGEKIVGKNVLIDEEMAQKIVDAGVKKVTIRSAFTCNTEHGVCERCYGRNAATGDRVEAGEAVGTVAAQSIGEPGTQLTLRNFHTGGVAGNDDITQGLPRIQEIVEARNPKGRATITEVTGEVVSIEENPAERTKDITIKGETDTRTYTLPITARMKVAEGDFIHRGAPLNEGSIDPKELIQVRDVLSTETYLLSQVQGVYRMQGIDLLDKHVEIMIRQMMRKVRVMDPGDTDLLPGQLMDISQFRDANKDTLVAGNIPATARPVILGITKAALETNSFLSAASFQETTRVLTDAAIRGKNDPLVGLKENVIIGKIIPAGTGMSAYRNIKPKEVSVAAYSIKDIEAKLKEEDKQN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: FCN2_MOUSE
Sequence: MALGSAALFVLTLTVHAAGTCPELKVLDLEGYKQLTILQGCPGLPGAAGPKGEAGAKGDRGESGLPGIPGKEGPTGPKGNQGEKGIRGEKGDSGPSQSCATGPRTCKELLTQGHFLTGWYTIYLPDCRPLTVLCDMDTDGGGWTVFQRRLDGSVDFFRDWTSYKRGFGSQLGEFWLGNDNIHALTTQGTSELRVDLSDFEGKHDFAKYSSFQIQGEAEKYKLILGNFLGGGAGDSLTPHNNRLFSTKDQDNDGSTSSCAMGYHGAWWYSQCHTSNLNGLYLRGPHKSYANGVNWKSWRGYNYSCKVSEMKVRLI
What is the function of this protein?
May function in innate immunity through activation of the lectin complement pathway.  Calcium-dependent and GlcNAc-binding lectin (By similarity).
What are the official names of this protein?
Ficolin-2, Collagen/fibrinogen domain-containing protein 2, Ficolin-B, Ficolin-beta, L-ficolin.
What is the protein family that this protein belongs to?
Belongs to the ficolin lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL4_METPB
Sequence: MKLDITTLDGGSAGSLELNEAIFGLEPRADILQRMVRYQLAKRRAGTHAVKNRSDVDRTTKKLYKQKGTGNARHGAASAPQFRGGGRAFGPVVRDHSHDLPKKVRALALKHALSSKAKTSTLIVVDDIKVDSHKTKAMIERFEKLGLSSALIIGGSEVDENFGRAARAIPKIDVLPVQGINVYDILRRDTLVLTRAAVDALEERFK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RL6_PECCP
Sequence: MSRVAKAPVVIPAGVEVKLNGQDISIKGKNGELSRKIHDAVEVKQADNALTFAPREGFVDGWAQAGTTRALLNAMVIGVTEGFTKKLQLVGVGYRAAVKGNVVNLSLGFSHPVDHALPAGITAECPSQTEIVLKGADKQVIGQVAAELRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: EFTU_ACIAD
Sequence: MAKAKFERNKPHVNVGTIGHVDHGKTTLTAAIATICAKTYGGEAKDYSQIDSAPEEKARGITINTSHVEYDSPIRHYAHVDCPGHADYVKNMITGAAQMDGAILVCAATDGPMPQTREHILLSRQVGVPYIVVFLNKCDLVDDEELLELVEMEVRELLSTYDFPGDDTPVIRGSALKALEGDAGQYGESSVLALVEALDTYIPEPERAIDKAFLMPIEDVFSISGRGTVVTGRVEAGIVKVGESVEIVGIRDTQTTTVTGVEMFRKLLDEGRAGENCGVLLRGTKREDVQRGQVLAKPGTIKPHTKFDAEVYVLSKEEGGRHTPFLNGYRPQFYFRTTDVTGAIQLKEGVEMVMPGDNVEMSVELIHPIAMDPGLRFAIREGGRTVGAGVVAKVTA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.