PharMolix/UniProtQA huggingface dataset:
Protein: RAD25_ANTLO
Sequence: MTRCGWHTCTRVRPRMGETLLPRKASQHEFEPEEIRMKQEHTECPLLVSHNGIIILETFTANAKQATDFLIAIAEPVSRPAHVHEYRITPYSLYAAVSVGLTTEDILSTLDRFAKNTVPDTIVRFVRECTLSYGKTRLVFKGGRFLVEAATREVFDVLTGDAEISRLRAAGTVRDADARYVFEVRVDCIEQVRRRCIEIDYPMIEEYDFRDDVALRSLDMDLRDTVSIRTYQEVSLNKMFGNRRARSGVIVLPCGAGKTLVGITAMCTIKKPCIVLCTSGVSVEQWRQQVLAFSTVSADAVSRFTSERKEMFEADAGILITTYTMLAFSGRRSAEAQRVMEWLRGTEWGLMILDEVHVVPAAMFRKVVSAVSHHCKLGLTATLVREDDKIEDLNFLIGPKLYEADWQDLSMQGHIARVECVEVWCDMTAEFYREYLGQDPRRRRVLSIMNPAKFQTCEFLIRKHEALGEKIIVFSDNVLALRTYALKLGKPFIYGPTGQTERMRILRQFQTNPAINTLFLSKVGDTSIDLPEASCLIQISSHFGSRRQEAQRLGRILRAKRRNDPGFRVYFYTLVSKDTEEMYYSRKRQQFLVDQGYTFRTVTALEGFRDTDVRVFRGKAEQRELLATVLLASEEDLESEESEDGDEAAADRRHLRTRGGAEDTVPASRTRTERHLLFRKMHKRHRR
What is the function of this protein?
ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH helicase subunit XPB, TFIIH subunit XPB, DNA repair helicase RAD25, RNA polymerase II transcription factor B subunit SSL2, TFB subunit SSL2, Suppressor of stem-loop mutation 2.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD25/XPB subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS12_RUEPO
Sequence: MPTIQQLIRKPRQPKVKRSKSQHLEQCPQKRGVCTRVYTTTPKKPNSAMRKVAKVRLTNGYEVISYIPGESHNLQEHSVVLIRGGRVKDLPGVRYHILRGVLDTQGVKDRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ARGP_SALSV
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENMFGQPLLVRTVPPRPTEQGQKLLALLRQVELLEEEWLGDEQTGSTPLLLSLAVNADSLATWLLPALAPVLADSPIRLNLQVEDETRTQERLRRGEVVGAVSIQHQALPSCLVDKLGALDYLFVASKPFAERYFPNGVTRSSLLKAPAVAFDHLDDMHQAFLQQNFDLPPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELESGELINLTPGLLQRRMLYWHRFAPESRMMRKVTDALLEYGHKVLRQD
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: CLPP_STRPZ
Sequence: MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGKTIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSG3_HUMAN
Sequence: MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.
What are the official names of this protein?
Medium-wave-sensitive opsin 3, Green cone photoreceptor pigment, Green-sensitive opsin, GOP, opsin 1 cone pigments medium-wave-sensitive 3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LOLD_EHRRW
Sequence: MSIVFALSAISKSFGKNNQVNIIINANLQIKKGEIVALIGPSGSGKSTLLHIAGLLDTPSSGSVFINNIECSATTSDREKTYLRRNFLGFVYQFHHLLQEFSVLENVMLPQIIIGKSNEVARKNAIELLSLVKLQDKLLMSISQLSGGERQRVAIARSLINYPSIILADEPTGSLDNDTALEVFSLLHKYAKEKNISVFLATHNHILAKKADKIVQINSGTLQNYTDY
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HEM1_CHLPM
Sequence: MNIISVGVNHKTAPIEIRERISLSEVQNKEFVTGLVSAGIAHEAMVLSTCNRTEIYVVPAMHEVTGEYLKDYIISFREAGKDVRPEHFFSRFYCGTARHLFEVSSAIDSLILGEGQILGQVKEAYRIAAEVQTAGILLTRLCHTAFSVAKKVKTRTKIMEGAVSVSYAAVELAQKIFSNLSMKKVLLVGAGETGELAAKHMFAKNARNIVITNRTRSKSEALAEELGTNQVLPYESYKEHLHEFDIIITAVSTKEYIISEAEMHAAMLKRRLKPVIILDLGLPRNVDPEVSKVQNMFLKDIDALKHIIDKNLERRSGELPKVHAIIDEELVAFGQWINTLKVRPTIVDLQSKFIEIKEKEIERYRHKVSEEELRRMEHLTDRIMKKILHHPIKMLKAPISTSDSMPSRVDLVRNVFDLEEPNQSH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: MMP11_XENLA
Sequence: MHLLILLPALCVLGAHSAPLSYTYLQHRIQEKPQKDHGRLQFNSLHYPHIKGLLNAHGSWNPPRCGVPDIPAPPDSSSGRNRQKRFVLSGGRWDKTNLTYKIIRFPWQLSKVKVRRTIAEALKVWSEVTPLTFTEVHEGRSDIIIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDEAWTIGNNIGTDLLQVAAHEFGHMLGLQHSSISKSLMSPFYTFRYPLSLSADDKHGIQFLYGAPRPPTPSPTPRVEVNQVENESNEIPAAEPDACKTNFDAVSTIRGELFFFKSGYVWRLRGGKLQNGYPALASRHWRGIPDTVDAAFEDSVGNIWFFYGSQFWVFDGKLQASGPFPITDIGISVTQIQAAFVWGTEKNKKTYLFRGGEYWRFNPETRRVESRHSRRIGDWRGVPKGIDAAFQDEQGYAYFVKGRQYWKFDPFKVRVMDGYPHLISQDFFNCQASSTFVNSLR
What is the function of this protein?
May be involved in the modification of the extracellular matrix during metamorphic apoptosis.
What are the official names of this protein?
Stromelysin-3, ST3, Matrix metalloproteinase-11, MMP-11.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: ISPH_ECOL6
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRVDIREVD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: EF1B_PYRCJ
Sequence: MSAEVALVYRVLPESVEVDVEKLKEAIVNRLAPKYKVDKVEVEEIGFGIKALRFYIRMPESDEYSSDEVEEILRSVEGVGGFELEYFSRLSF
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: BARD1_MOUSE
Sequence: MPRRPPRVCSGNQPAPVPAMEPATDGLWAHSRAALARLEKLLRCSRCANILKEPVCLGGCEHIFCSGCISDCVGSGCPVCYTPAWILDLKINRQLDSMIQLSSKLQNLLHDNKDSKDNTSRASLFGDAERKKNSIKMWFSPRSKKVRYVVTKVSVQTQPQKAKDDKAQEASMYEFVSATPPVAVPKSAKTASRTSAKKHPKKSVAKINREENLRPETKDSRFDSKEELKEEKVVSCSQIPVMERPRVNGEIDLLASGSVVEPECSGSLTEVSLPLAEHIVSPDTVSKNEETPEKKVCVKDLRSGGSNGNRKGCHRPTTSTSDSCGSNIPSTSRGIGEPALLAENVVLVDCSSLPSGQLQVDVTLRRKSNASDDPLSLSPGTPPPLLNNSTHRQMMSSPSTVKLSSGMPARKRNHRGETLLHIASIKGDIPSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKVVELLLQHNALVNTPGYQNDSPLHDAVKSGHIDIVKVLLSHGASRNAVNIFGVRPVDYTDNENIRSLLLLPEENESFSTSQCSIVNTGQRKNGPLVFIGSGLSSQQQKMLSKLETVLKAKKCMEFDSTVTHVIVPDEEAQSTLKCMLGILSGCWILKFDWVKACLDSKVREQEEKYEVPGGPQRSRLNREQLLPKLFDGCYFFLGGNFKHHPRDDLLKLIAAAGGKVLSRKPKPDSDVTQTINTVAYHAKPESDQRFCTQYIVYEDLFNCHPERVRQGKVWMAPSTWLISCIMAFELLPLDS
What is the function of this protein?
E3 ubiquitin-protein ligase.  The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability.  Plays a central role in the control of the cell cycle in response to DNA damage.  Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function.  Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
What are the official names of this protein?
BRCA1-associated RING domain protein 1, BARD-1, RING-type E3 ubiquitin transferase BARD1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.
Protein: ALKB4_MOUSE
Sequence: MAAAAEVSLLQECGCKGIRTCLICERQRHRDPPWQICLQKKCCFLYCPDTGWAAGAEGSDLEGWAFPFPGVTLIQDFVTPEEEAEMVRLMDCDPWKLSQSGRKKQDYGPKVNFRKQKLKMAGFQGLPGFSQKVVQRMGLYPGLEDFQPVEQCNLDYSPERGSAIDPHLDDAWLWGERLVSLNLLSATVVSMSPEAPGSLLLCSAPSVRPDAFEDSLVAPSRSVPCQEVEVAITVPRRSLLVLTGAARHQWTHAIHRRHIKARRVCATFRELSSEFLPGGKQQELGQELLQAALSFQGRPV
What is the function of this protein?
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (By similarity).  Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity).  In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (PubMed:30982744).
What are the official names of this protein?
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4, Alkylated DNA repair protein alkB homolog 4, DNA N6-methyl adenine demethylase ALKBH4, Lysine-specific demethylase ALKBH4.
What is the protein family that this protein belongs to?
Belongs to the alkB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody. Note=Associates with the contractile ring and midbody.
Protein: HIS8_METKA
Sequence: MDRVRPLAGGRNVRIREAVLNIDPYVPGKSKEEIAREYGIEPDEIVKLGSNENPLGPSPKAVKAAKRELERLHEYPEPLAPPSLYEAIIDYLADPPYPAGEPVEITREHLVVGGDGADEIIDVLTRVLVDPGDPVVIPVPTFSQYGISARACGAEVRKPRFDPERGFELDEDSLFEALDREVRLVYLCTPNNPTGNRIRERVVRDVVEECRGVVLIDHAYVEFADHDYTPLALEYDNVLVLRTCSKALGLAGARVGYGIANPELIEHLHRIKPVFSLTRPSAAAAEATFRDRDYIEKSVRLMIESRKYLYRELRKLDRLTPFPSEANYLLVDVSNTGMNASEFTEELLKRGVIVRDCSSFEGIEPFYVRVSTGTLEEDRKFIEVVKDVLEV
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: MRE11_METAC
Sequence: MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIQDAVDMQVDAVVHAGDLFDSRNPTLEDLLETMNILSRLKAVDIPFFGIVGNHESKQNTQWLDLFEEMGLAERLGKTPKLVGNTTIYGIDSVPKSKIPLYDYSGFELPDSLPENCKKLLVMHQIVQPFPYADWDCAEVLENLPFKVDAILLGDYHKYEKIKVGEEETWATYSGSTERNSASENEPRSYNIITLSGEGLEISRRTIPTRNFLFITAKIDGEEKPYEQIFSAINEHLEEIPESVVFLDISGNSDSVLSFSEIEEYLLSKGALVSKVKDARIKETLPEEVAKVAFSDPDHAVAEEIRRMSLNDGGLIVDEIIRSPDVVRSRVDEETENRLLRLIETIDFEDPDFRIEIPASPISSTDSIDPVSPINHPVSSADSVSAVSPESSADHVSPDIIENNEKPIPAVEAEKIETLDPAGETEFVAGIAGKTETFRAPVRIKNSESLNEALKKSYEAPDKVREAPDVNPEPPEPLPAFKNIGSPETFGSCETTVSSEVPEKGGERTELEDDAVNKTEKETGKLSGFGVEAGSEKEDADRIEKPAHVPDKAEKPVKQSQRKGKGKSAVPRQYNLGDYL
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair.  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA.  Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
What are the official names of this protein?
DNA double-strand break repair protein Mre11.
What is the protein family that this protein belongs to?
Belongs to the MRE11/RAD32 family.
Protein: FACE2_RAT
Sequence: MAALGGDGLRLLSVSRPERQPESAALSSPGPGLCCWVSVFSCFSLACSYVGSLYVWKSELPRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLCMDCPCDLTDGLKVVLAPRSWARRLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCTGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGSIFLSAGHLIGPVLCHSFCNYMGFPAVCAALEHPQKWPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCMLLERTGASETLLCS
What is the function of this protein?
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins.  Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity).
What are the official names of this protein?
CAAX prenyl protease 2, Farnesylated proteins-converting enzyme 2, FACE-2, Prenyl protein-specific endoprotease 2, RCE1 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase U48 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VATA_MESAU
Sequence: VGHSELVGEIIRGVNVSALSRHKIMLPPRFSMVQVWPVRLPANHPLLTGQRRTALVANTSNMPVAAREASIYTGITLSEYFRWAEALREISGRLAEMPADSGYPAYLGARKHFPSVNWLISYSKALDEYYDKHFTEFVPLRTVGMLSNMISFYDMARIKADYAQLLEDMQNAFR
What is the function of this protein?
Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).  May play a role in neurite development and synaptic connectivity (By similarity).
What are the official names of this protein?
V-type proton ATPase catalytic subunit A, V-ATPase subunit A, V-ATPase 69 kDa subunit, Vacuolar proton pump subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Lysosome. Note=Co-localizes with WFS1 in the secretory granules in neuroblastoma cell lines.
Protein: CHLB_EQUAR
Sequence: KRLLEDLGIKINEIIPEGASVKNLINLPKAWFNIVPYREVGLMTASFLQKDFGMPYILTTPMGIIDTADFIRQVQKNVNKLAPFFLNKTFDYESYIDYQTKFV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex (By similarity).
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MURA2_BACC1
Sequence: MEKLLIEGGRALNGTIRVSGAKNSAVALIPATILADTPVTIGGVPNISDVKMLGDLLEEIGGRVTYGQEEEMVVDPSNMVAMPLPNGKVKKLRASYYLMGAMLGRFKKAVIGLPGGCHLGPRPIDQHIKGFEALGAHVTNEQGAIYLRADELRGARIYLDVVSVGATINIMLAAVRAKGRTVIENAAKEPEIIDVATLLTSMGARIKGAGTDVIRIDGVDSLHGCHHTIIPDRIEAGTYMILGAASGGEVTVDNVIPQHLESVTAKLREAGVQVETNDDQITVNGDRRLKVVDIKTLVYPGFPTDLQQPFTTLLTKAHGTGVVTDTIYGARFKHIDELRRMNAQIKVEGRSAIVTGPVLLQGAKVKASDLRAGAALVIAGLMADGITEVTGLEHIDRGYENIVDKLKGLGANIWREQMTKQEIEEMKNA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2, Enoylpyruvate transferase 2, UDP-N-acetylglucosamine enolpyruvyl transferase 2, EPT 2.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TVAM1_HUMAN
Sequence: MTSIRAVFIFLWLQLDLVNGENVEQHPSTLSVQEGDSAVIKCTYSDSASNYFPWYKQELGKGPQLIIDIRSNVGEKKDQRIAVTLNKTAKHFSLHITETQPEDSAVYFCAAS
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 13-1.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RL34_VIBC3
Sequence: MSKRTFQPSVLKRKRTHGFRARMATANGRKVLNARRAKGRKRLSK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RS15_NEIG1
Sequence: MALTVEQKAQIVKDFQRKEGDTGSSEVQVALLTFRINDLTPHFKANPKDHHSRRGLLKMVSQRRRLLAYLRRTQPDTYRALITRLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: HUT1_CANAL
Sequence: MTTQKQHQQQHHLQSGQEKNKALTLIICVCGLYGTFLTWSILQERINTKPYGDNNEYFKAPIIINLIQALFASIIGFIYNYVTTTTTSTKTTTKTKTKTNSNPFSIFFTNGKQNCNVLKFMILISITSSIASPIGYKSLKHLDYLAYLLAKSCKLIPVMIVHFIFYQTKFPNYKYLVAGLVTLGVILFTMAHVTTKTKINDGNTLLGLTYLIGSMILDGLTNSTQDQLFKLPLENKLTSGKLMSLLNLFIFIWTSLYTIIFHKYEIDYTINFINNYPELLIDIIGFAICGAIGQVFIFIILEKFDSIILITATVTRKMLSMILSVILFGHHLSWEQWVGVGLVFGGIGLEAFIKFKQQSQQKMKIKSKVA
What is the function of this protein?
May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen.  Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity).
What are the official names of this protein?
UDP-galactose transporter homolog 1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PTG3C_STAAE
Sequence: MRKKLFGQLQRIGKALMLPVAILPAAGLLLAIGTAMQGESLQHYLPFIQNGGVQTVAKLMTGAGGIIFDNLPMIFALGVAIGLAGGDGVAAIAAFVGYIIMNKTMGDFLQVTPKNIGDPASGYASILGIPTLQTGVFGGIIIGALAAWCYNKFYNINLPSYLGFFAGKRFVPIMMATTSFILAFPMALIWPTIQSGLNAFSTGLLDSNTGVAVFLFGFIKRLLIPFGLHHIFHAPFWFEFGSWKNAAGEIIHGDQRIFIEQIREGAHLTAGKFMQGEFPVMMFGLPAAALAIYHTAKPENKKVVAGLMGSAALTSFLTGITEPLEFSFLFVAPLLFFIHAVLDGLSFLTLYLLDLHLGYTFSGGFIDYFLLGILPNKTQWWLVIPVGLVYAVIYYFVFRFLIVKLKYKTPGREDKQSQAATASATELPYAVLEAMGGKANIKHLDACITRLRVEVNDKSKVDVPGLKDLGASGVLEVGNNMQAIFGPKSDQIKHEMQQIMNGQVVENPTTMEDDKDETVVVAEDKSATSELSHIVHAPLTGEVTPLSEVPDQVFSEKMMGDGIAIKPSQGEVRAPFNGKVQMIFPTKHAIGLVSDSGLELLIHIGLDTVKLNGEGFTLHVEEGQEVKQGDLLINFDLDYIRNHAKSDITPIIVTQGNITNLDFKQGEHGNISFGDQLFEAK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in glucose transport.
What are the official names of this protein?
PTS system glucose-specific EIICBA component, EIICBA-Glc, EII-Glc, EIICBA-Glc 1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OPPC_LACLA
Sequence: MTEKKHKNSLSLVHSIKEELKKDKLAMISTIFLVAVFLIVYIYSMFLKQSNYVDVNIMDQYLAPLTNGHLLGTDNGGRDIIMMLMISARNSFNIAFAVTLITLVVGNILGVITGYFGGRFDLIFMRFTDFVMILPSMMIIIVFVTIIPRFNSWSLIGIISIFSWIGTTRLIRARTMTEVNRDYVRASKTSGTSDFKIMFREIWPNLSTLVIAEATLVFAGNIGLETGLSFLGFGLPAGTPSLGTMINEATNPETMTDKPWTWVPATVVILIVVLAIIFIGNALRRVADQRQATR
What is the function of this protein?
Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Oligopeptide transport system permease protein OppC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.