PharMolix/UniProtQA huggingface dataset:
Protein: LONP2_PICST
Sequence: MARYKNPKSPAKLKQQIVLPTCKLDSNLVLLPGIIYNVTFSRFKAAALLYRYKDLVSQVSIINNLLNEYEFNPSKDSDSVEEDDMVTSPITISKVAVEGIEQFFKYEAAFKNSQGLVSEKDIAEVAPSNEFDWLTLAIKPNLEKIKEPSNAQIDPTEHNSVVTIARIVGIVDDTTNIKLTLQAITRGLKIAPKKKTRPNEQLLEVDWSSDIPELRRHFKSLKDSSLDLFKVIDKFIVDYRQALSINSANGNKSNLQITKPGSRYKGANGSSQKPGDLLTLNPLANALYLQLAGSKDFSKAFLSLQKLYGQFASDENLKVDTKSYLRLLDLTCGILPFPNHEKLKLLHKISIDDRGNELINMINQLIKIFDTLDGNNSFVNHWFYNEATNIQKANVVANQLKSIRLLLEGMTNKTRPISNRGNIKSFNNSENGNNNKTNGSGITSRRPKSNEDGGEVYDEEDDDEEDDELRAITNFIKYKLPNITTLSPDSKRLIIKDFKRIRASSQSPGGGGNSDFHVIRNYLEIVMDIPWDKYVTKFKSNKDIDLNFAKKQLDDDHYGLEHVKKRLIQYLVVLKLLGINAEKQISDFRKENQVPSPSSSGSNLATQNSLVPASSIVIANNDETSFAHKQAQNKVKTSIKESNIENQTNQSIQVTKYNKSPIIMLAGPPGTGKTSLAKSIASSLGRNFQRISLGGVKDESEIRGHRRTYVGAMPGLIIQALRKSRSMNPVILLDEIDKVIGGSSGVNKFNGDPSAALLEVLDPEQNTSFIDHYLGFPVDLSQVIFICTANEPHNLTRPLLDRLEMIEVSAYDYNEKLIIGRKYLLPRQVKRNGFPASDRIEEFVNIDDASMKKIIVDYTREAGVRNLERKLGTICRFKAVEYCEGLSGKSFYNPNVEEADLPKYLGIPYSSGDFSSIETTISNNSRVGIVNGLSYNSDGSGSVLVFETIGFDKRVGNPNSSNTGCSLVMTGRLGEVLMESGKIGLTFIKSLIYKNLIQAKEQPDDKYLIEKFNNLELNLHVPMGSISKDGPSAGITMATSFLSVILDKPVPADVAMTGEITLRGLVLPIGGVKEKMMGAHLNGNIRRMIVPRENRKDLIEEFSRSVEEAGDVVDSNLMNELLKDNEEADFKMDKVEKFYLKRYGIQIFYAREFYDVMKILWGEDDLLTKPKSNRILEYHL
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix.  Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
What are the official names of this protein?
Lon protease homolog 2, peroxisomal.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Peroxisome matrix.
Protein: P7629_TITST
Sequence: TKCPTCQNDTCSNKI
What are the official names of this protein?
Peptide 7629.
What are the subcellular locations of this protein?
Secreted.
Protein: HSD_MYCTU
Sequence: MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT
What is the function of this protein?
Probably involved in steroid metabolism.  Catalyzes the oxidation of androsterone (3alpha-hydroxy-5alpha-androstan-17-one) and 20beta-hydroxyprogesterone (4-pregnen-20beta-ol-3-one), and the reduction of progesterone (4-pregnen-3,20-dione).  Shows a preference for NADH.  Has no detectable activity for oxidation of L-3-hydroxybutyric acid and only an insignificant activity for reduction of acetoacetyl-CoA.
What are the official names of this protein?
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase, NADH-dependent 3alpha, 20beta-hydroxysteroid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: REM2_MOUSE
Sequence: MHTDLDTDMDMDTETVALCSSSSRQASPLGTPTPEADTTLLKQKPEKLLAELDLSGPPPAPGVPRRRGSMPVPYKHQLRRAQAVDELDWPPQASPSGSSDSLGSGEAALTQKDGVFKVMLVGESGVGKSTLAGTFGGLQGDHAHEMENSEDTYERRIMVDKEEVTLIVYDIWEQGDAGGWLQDHCLQTGDAFLIVFSVTDRRGFSKVPETLLRLRAGRPHHDLPVILVGNKSDLARSREVSLEEGRHLAGTLSCKHIETSAALHHNTRELFEGAVRQIRLRRGRGHAGGQRPEPSSPDGPAPPTRRESLTKKAKRFLANLVPRNAKFFKQRSRSCHDLSVL
What is the function of this protein?
Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.
What are the official names of this protein?
GTP-binding protein REM 2, Rad and Gem-like GTP-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. RGK family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: KLEA1_ECOLX
Sequence: MSKNKIMPWVDALPNVEATDFQARRDQIEATMAEAAELVKQAEELRGKAYFAALSLEASAKGEWSSQAVEQAKRSVGW
What are the official names of this protein?
Protein KleA, KcrA1 protein.
What is the protein family that this protein belongs to?
To E.coli KleC (kcrB1).
Protein: XPT1_CRYNJ
Sequence: MPPTALPPLRPPAQPYDSYSSSLSPSSPRFHPASAPHGRRAPSPSRLESLLDAPHAPARSPSRKIRSALSRHIRPHLTPRTLTPLLLWTLALWLVHHFLFPFSSPLAALSRPKAEQHFLSTTFPPPPQRLGDDRLDSVDPRWRAFHPLPPPEPPFPRLRPTRFLPPQCLEQWFADGETLCGAKEMGEEETLDATWLWVNGSDHRWRDSMAEWREKENVNSPERHFREQNELVHSMRSVLDALPGHLRTFHLILADYPFNYPEDLDLVPPSIIPDLEVAASKGGQGRRHPRELARAPASVSNLTERLTPESISPSLARHLQSEWRILQTPTWLDFSRRDPSDPSHPFHPYSVSKAGEMRQHYAEASYPTLRYASHWEVFHIPSVDRDGREELMGEREWRENEWKKKALPSFNSMAIESRIGWLPGLADAIIALNDDFFLLRPHAVSDFHSPLYGSVIRFEHSYNQQVKPDVEKNHINDPGEMGGLYHANALLSRRFPHRLRPYFAHVPKVITRGLHHEASLMFQEALTLSSTRKFREMKIGEGDVQMQWLLTSLRVERWREALLWTWVVANMGTLSGSHDRWDSDTRSAIKHLFGFTEDDDDVVKIEVHRGERWTLEPGRMQKVFHQAGWEAPKATEFLFSSMDGIMPPLLRSGEDPSQNDRCIIDLNRCFGVFWTRQEDVLSADMMKRLTFQYPECGDCMIMALVTASGTLGLNAFFPPKETTITAPELGPGDAYPKYLPPPHLPLTPTWHEADYSLSNILSTTALPGEQVDIRQYCMRLLSRYLYLDAKSVSHFHMMKSAEHAKRVFKMIQDNPKVSILGMNDDIESDYDEVKRLMNEWFEMRWPRKAVWERDWDPVKDRYHD
What is the function of this protein?
Xylosylphosphotransferase that is specific for UDP-xylose as a donor and mannose as an acceptor to form a xylose-alpha-1-phosphate-6-mannose linkage.  Functions in the O-glycosylation of proteins en route through the secretory pathway (By similarity).
What are the official names of this protein?
3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase, Xylosylphosphotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the XPT1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type I membrane protein.
Protein: ORN_SHEON
Sequence: MAADANNLIWIDLEMTGLEPDVDRVIEIATLVTDQELNIIGQGPVIAIHQSDEVLAAMDDWNQKHHGESGLIERVRASQVNEAEAVAQTIAFLAQYVPKGVSPMCGNSVGQDRRFLNRYMRELEDYFHYRNLDVSTVKELVKRWSPETMAGFKKQNTHQALQDIQESIAELQYYRSKVFKI
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKA_VIBCM
Sequence: MTVMEHTKAAQIDLAQYGITGVTELVRNPSYEMLFAEETRSDLEGYERGVVTELGAVAVDTGIFTGRSPKDKFIVKDDTTRDTLWWTSDKAKNDNKPINQEVWNDLKALVTKQLSGKRVFVLDGYCGANADTRLSVRFITEVAWQAHFVKNMFIRPSEEELAHFKPDFVVMNGAKCTNAKWKEHGLNSENFTVFNLTERMQLIGGTWYGGEMKKGMFAMMNYFLPLQGIASMHCSANMGKAGDVAIFFGLSGTGKTTLSTDPKRALIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPDIYNAIRRDALLENVTVRSDGSIDFDDGSKTENTRVSYPIYHIDNIVKPVSKGGHATKVIFLSADAFGVLPPVSKLTPEQTKYHFLSGFTAKLAGTERGITEPTPTFSACFGAAFLTLHPTQYAEVLVKRMEAAGAEAYLVNTGWNGSGKRISIKDTRGIIDAILDGSIEKAETKHIPIFNLQVPTALPGVDPMILDPRDTYVDPLQWESKAKDLATRFINNFDKYTDNAEGKALVAAGPKLD
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_BURP0
Sequence: MTQSTTEDTLLRLAAVIDSRKGGDPEQSYVSRLFHKGDDAILKKIGEEATEVVLAAKDVRQGGAPSALVGEVADLWFHCLVALSHFDLSPADVIAELERREGMSGIEEKALRKRREREENGG
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERC_NEIMA
Sequence: MVLDGFAAHFDAYLENIVREGKSEHTVAAYRRDLEELFALLAQMPSEDAGGVPQGLSQRDFTAALRRLSQRGLNARTLARKLSSWRQYCAWLVKRGLLHTDPTADIKPPKQPERVPKALPQEWLNRMLDLPVDGGDPLAVRDHALFELMYGSGLRVSEIHGLNADDVYLDEAWVHVTGKGRKQRQVPLTGKSVEALKNYLPLRQTASDGKALFTGRNGTRLSQRQIQKRLAQWAAQNGDGRHVSPHMMRHSYAGHLLQASRDIRAVQELLGHSSLSTTQIYTKLDFDHIARLYDEAHPRAKRQDE
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_SHEPW
Sequence: MKIRIGHGFDVHKFGGEPPLILGGVTVPYEVGLIAHSDGDVVLHAISDAILGAMALGDIGKHFPDTDAEFKGADSRVLLKHCYQLALNMGFSMSNLDVTVIAQAPKMAPHIEAIRSVIAADLQSDIDDINVKATTTEKLGFTGRKEGIAVEAVVLMTKI
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RMT2_ASHGO
Sequence: MSLLHHLVTLPSRPITRDAYLPQLQNLLRSGIPATYTLEQLAAYEKGDEEGPGDEDTNTTPLHIMARSLPEAGQLSEAESEVVLEIMDTLFQYGAGWNFLDYEQKHAGDLLLEKGYGPGDALYERLVEAGVAAELLLRKVNGGEIEFLDGSDTEMGDKGGSARDVPASADSAPADSAGHSSSEPTAVDADATAAHQDTYLQTELEYIPGALVTKHNRDGVMMDWETDIMRVAAASIVKNREPAECQVLNIGFGMGIIDGFLQEQRPTRHYICEAHPDVLARMRREGWYERPDVVILEGRWQDTLSRLLDDGTVFFDGIYYDTFSEHYTDMLELYDLVVGLIKPCGIFSFFNGLGADRQVCYDVYRRIVELDMATYGMTCEYTTIDLRQLPTWDNVRRSYFNCDHYYHPEISFQ
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins.  Monomethylates ribosomal protein L12.
What are the official names of this protein?
Protein arginine N-methyltransferase 2, Protein-arginine N5-methyltransferase, Type IV protein arginine N-methyltransferase, Type IV PRMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ECOT1_LEIIN
Sequence: MSYCKIEAPYPTAEAGEKRIIFALDPKGDEAEQEQYMLQLIPGRVLEMSRNDAANHQTLGGSIEQHTVEGWGAKFFHVKLAKQAASTLMHVHDEDHSEKVRKFVAMPNPPLFPYRSRCPVVVYLPNDAELRYGIWCGGQQMQAVTE
What are the official names of this protein?
Ecotin-like protein 1, Inhibitor of serine peptidase 1, LiISP1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
Protein: LPXC_ACTPJ
Sequence: MIKQRTLKQATKVTGIGLHSGKKVTLTLRPAPANTGIVYARTDLEPAVYFPASAESIRDTQLCTCMINDDGVRISTVEHLNAAMASLGLDNLIVEVDAPEIPIMDGSASPFIYLLLDAGIEEQDAPKKFIRIRETVRVEEGDKWAEMKPYSKGLKLDFTIDFSHPMISKDVRNFKMELSAENFIHKISRARTFTFMKDVEYLQSIGLALGGSLDNAIVLDKYRILNEEGLRYKDELVKHKMLDSIGDLFMCGYNILGDFSAYKSGHGLNNKLLRAILANENAWEFVTFEDKEQAPEGYRIGEQVFI
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: RS17_DESOH
Sequence: MKTRGLKRQFEGTVVSDKMDKTVIVAVERLVKHQEYKKYVRRTAKFAAHDEQNQCAVGDKVIITESRPLSRTKHWRVVNVVEKAV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: KPPR_SYNY3
Sequence: MTTQLDRVVLIGVAGDSGCGKSTFLRRLTDLFGEEFMTVICLDDYHSLDRQGRKAAGVTALDPRANNFDLMYEQIKTLKSGQSIMKPIYNHETGLLDPPEKVEPNKVVVIEGLHPLYDERVRELVDFGVYLDISEEVKINWKIQRDMAERGHTYEDILASINARKPDFTAYIEPQKQYADVVIQVLPTRLIEDKESKLLRVRLVQKEGVKFFEPAYLFDEGSTIDWRPCGRKLTCTYPGIKMYYGPDNFMGNEVSLLEVDGRFENLEEMVYVENHLSKTGTKYYGEMTELLLKHKDYPGTDNGTGLFQVLVGLKMRKVYEQLTAEAKVPASV
What are the official names of this protein?
Phosphoribulokinase, PRK, PRKase, Phosphopentokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoribulokinase family.
Protein: SELU_SERP5
Sequence: MSATREREDGQDYRRIFLQDIPLIDVRAPVEFQQGAFANAVNLPLMNDDERQAVGTCYKQQGQQAAIALGHSLVNGRLREQRTAAWLAQCAQWPEGYIYCFRGGLRSQLVQQWLREAGVAYPRITGGYKALRNFLLTTLEQSAELPMVLIGGNTGSGKTLLVNELADGVDLEGAAHHRGSSFGRTLVSQSGQIDFENRLAVLLLKKQHGGCRRWVLEDEGRIIGSNNLPLPVFNRMQQAPVAVIDDPFEVRLARLQHEYIDRMRIEFEQAYGAQLGWQKYDEYLHHGLFAIRRRLGLERFQLLTQHLERALQYQQASGNSDEHQQWLVPLLQHYYDPMYHYQLEKKSQRIVFRGNYAEVREFLMTYSQNNGE
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: TCP21_ARATH
Sequence: MADNDGAVSNGIIVEQTSNKGPLNAVKKPPSKDRHSKVDGRGRRIRMPIICAARVFQLTRELGHKSDGQTIEWLLRQAEPSIIAATGTGTTPASFSTASLSTSSPFTLGKRVVRAEEGESGGGGGGGLTVGHTMGTSLMGGGGSGGFWAVPARPDFGQVWSFATGAPPEMVFAQQQQPATLFVRHQQQQQASAAAAAAMGEASAARVGNYLPGHHLNLLASLSGGANGSGRREDDHEPR
What is the function of this protein?
Transcription factor involved in the regulation of the circadian clock.  Acts as a repressor of CCA1 by binding to its promoter.  No binding to the LHY promoter.
What are the official names of this protein?
Transcription factor TCP21, Protein CCA1 HIKING EXPEDITION, Protein CHE.
What are the subcellular locations of this protein?
Nucleus.
Protein: MFD_STAA8
Sequence: MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFIDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNVEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIEYFQKDAIIAVDEFNRIKETEESLTVESDSFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA
What is the function of this protein?
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions.  Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
What are the official names of this protein?
Transcription-repair-coupling factor, TRCF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the helicase family. RecG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_CHLT3
Sequence: MERTLAILKPDCVRKNLIGAAIEKIQSAGFKVVAMKMTRLTKETAGEFYAVHKARPFYGELVEFMSSGACVPLMLEKENAVADFRTLIGATDPAEAAEGTIRKLYADSKGENIVHGSDSVENAKIECGFFFSTQEAVANMA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_XYLFT
Sequence: MNNFASNDPLVIAGTVYSSRLLTGTGKFKDLDETRLATEAAGSQIVTVAIRRVNIGQDPHQPNLLNVLSPDRYAILPNTAGCYTAEDAVRTCRLARELLDGHRLTKLEVLGDKKTLYPDVVQTLKAAEQLVAEDFQVMVYTSDDPILAKRLEEIGCVAVMPLAAPIGSGLGVQNRYNLLEIIENAQVPIIVDAGVGTASDAAIAMELGCDAVLMNTAIAGARDPVLMASAMRKAVEAGREAFLAGRIPRKRYAAASSPVEGLVG
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTC1_CHICK
Sequence: MASAADALEPESGSSTAGGGSHPVRAARSARGRRRRSGGTRRAAAPDREYLQRPSYCDAAFALEQIAKGRATGRRAPLWLRAKFQRLLFNLGCYIQKNCGKFLVVGLLYSAFAVGLRAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPQEDGTNVLTTEALRQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITEAGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLQWINFDPLEFLEELKKINYQVESWEEMLNKAEVGHGYMDRPCLNPADPDCPITAPNKNSTKPLDVALVLSGGCYGLSRKYMHWQEELIIGGTVKNSSGKLVSAQALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRMYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVTRVIQIEPQAYAENDNICYSSPPPYSSHSFAHETQITMQSTVQLRTEYDPHTQAYYTTAEPRSEISVQPVTVTQDSLSCQSPESASSTRDLLSQFSDSSVHCLEPPCTKWTLSTFAEKHYAPFLLKPKAKVVVIFLFLGLLGLSLYGTTRVRDGLDLTDIVPRDTREYDFIAAQFKYFSFYNMYIVTQKADYPNVQHLLYELHRSFSNVTYVLLEGDRQLPKMWLHYFRDWLQGLQDAFDSDWETGKITYSNYKNGSDDAVLAYKLLVQTGNRAKPIDISQLTKQRLVDADGIINPNAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRETSDFVEAIEKVRAICNNYTSLGIASYPNGYPFLFWEQYIGLRHWLLLSISVVLACTFLVCALFLLNPWTAGIIVVVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHIALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPACGRNRLPTPSPEPPPSIVRFALPPGHTNNGSDSSDSEYSSQTTVSGISEELHHYEATQSPGIPVHQVVVEATENPVFARSTVVQPESRHQSSPRLQSNPEAGTQQVWHQGRQPKQEVREGLRPPPYRPRRDAFEISTEGHSGPSNKDRLNHKAHSHNMRSPAFGAMGVPGSAYCQPITTVTASASVTVAVHPAVHSHNSCRGSFPSCEEYNEDDRGMFEDPHVPFNVRCERRNSKVEVIELQDVECEERTAGKISE
What is the function of this protein?
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH).  Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.
What are the official names of this protein?
Protein patched homolog 1, PTC, PTC1.
What is the protein family that this protein belongs to?
Belongs to the patched family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PIP11_VICFA
Sequence: MEGKEEDVRVGANKFPERQPIGTSAQSDKDYKEPPPAPFFEPGELSSWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRALYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHSWDDHWVFWVGPFIGAALAALYHVVVIRAIPFKSRS
What is the function of this protein?
Water channel required to facilitate the transport of water across cell membrane.  Its function is impaired by Hg(2+).
What are the official names of this protein?
Aquaporin PIP1.1, Plasma membrane aquaporin 1, Aquaporin 1, Plasma membrane intrinsic protein 1a, PIP1a.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUVA_LYSSC
Sequence: MYDYLKGLITRITPEYIVLEQKGIGWQLNTPNPFAFRTSAMEQQIYVHLHVREDAQVLYGFPNLDQRELFRKLILVSGIGPKGALAILATGNPQQVISAIEREDETFLVKFPGVGKKTARQMILDLKGKLGSLLETIELPSTEDELPLFGVHPYKHELEEAILALAALGYSEKELEKIRPLLEDNDKLETTDAYMKQALQLLLKLK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: MALEP_LEVBA
Sequence: MEITKSAAGTLNQQDVSKYVLTNQQGTQVAVLTWGATLQEFSVVEDGKRHSLIVNKPDLAGYDHNPYYLCQALGRVAGRIAGAQFELDGQTVHLEANEEPNASHGGPHGFTFVNWDATTNQTADTASVVLTHTSTPADDRYPGNLETTITYTLTEENRLDITFDAQSDAATLFNPTIHTYFNVTDDQHDLDQQWVKLSGDKRLVLDQAKIPTGEMVPTAGTGYDFSQPRTVKDGLDQLHQTGQVEYDDAFVVEPSKDTPIATIGDTTGHREVSIYSDRNGLVVFTANPTDDARADVRDYNALAMEAQTLPDAIHHADFGDVVLPANQPVEHTISYQYTRK
What is the function of this protein?
Catalyzes the interconversion of alpha and beta anomers of maltose.
What are the official names of this protein?
Maltose epimerase.
What is the protein family that this protein belongs to?
Belongs to the aldose epimerase family.
Protein: GLMM_CITBB
Sequence: MKKLFGTDGVRGVANVYPMTAEMAMQIGRAAAYIFKNGKKRHRIVIGKDTRLSGYMLESALMAGICSMGVDVLLVGPLPTPGIANITSSMRADAGVVISASHNPFEDNGIKFFSRDGFKLPDETELMMEELIFSKRIDSLRPTAKEVGKAYRIDDAQGRFVVFLKSTFPKDLDLSGLKIVLDCANGAAYKVAPAVFEELGAEVISIGVKPNGTNINADCGSLHPEVMSQAVKEHGADLGVALDGDADRVIFVDEYGNVVDGDRIMAICATEMIRQGILKQNTLVATVMSNMGLDIAMKRAGGQVIKTAVGDRYVVEEMLKGGYNLGGEQSGHMIFLDHNTTGDGVLSALQVLAIMQRHQKRLSELALVMEPLPQVLVNVRLAEKSDIMQVPEIAKLINDVEEKLKGEGRVLIRYSGTEPLLRIMLEGSDEGDIRCWANDIASIVAQKLGGEARG
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RN186_HUMAN
Sequence: MACTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAFCAICLKLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCPQGLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWVLTFIIALALLMSTLFCCLPSTRGSCWPSSRTLFCREQKHSHISSIA
What is the function of this protein?
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress (PubMed:23896122).  Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis (PubMed:23896122).  Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens.  Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR (PubMed:34623328).  Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3.  Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction (PubMed:33280498).  Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity (PubMed:31586034).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF186, RING finger protein 186.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.