Protein: HEAT1_DANRE
Sequence: MTSLAHQLKRLALPQNDSSLLGRKEVVSVLFDPKDAASMDRSTFHALGCTGLEELMGIDAAFSEFQETLFSQGSLTLERSVQSKEVNKKLDKSISLFLTRLSPYFLLKPALKCIEWLLHRFHIHLYNQDSLIACVLPYHETKVFVRVIQLFKIEDPTHKWHWLHGIQKPGVPLARGTLLTHCYKDLGFMDFVCSMVTNSVKAYSELTRDGNCPQLRVIFSFYASTIVSALDAVEKITNSIIAKLLPFVQLGLKSNLSDYTAATYMIVCQMAVKVVMEAQLVDSLSVQLSRSLGRTPQLIREGLSCIIILLQNQKKGVIGQKTYGYLCAVPTLVSTLQSISTVHDISPLLSYLLPHLIHSVMTQNDEQQNEGLSDSTGLLQSVFQNLQLSSNLENTAAKLLLEEYVVCGNELPSDGISALNQRIQPTVRLFESRYPCALDMALENHVKNVSSDNEKNLLHQFISLTLSCGKYQILPESETSLMLSLNHPLPSVRNMAVDYLKEILNSEHNSFDEAFLKDALLERIKDDSPEVVLSALKALQHHMGLMDVEDTVSSLISLLHRIKPSADWCPVLKEAVRVLDDPRIIEGNPDLKAYISWELLPFLVMTRAAPECVELQMTSAITETTLISQHPLTQGWAKVLKAVLAKTSESDLLGVANEMLTTTLIKNLANMDHATKRNTLENVCDILSRQGSSVRDRAAFVVFSSALLQSLQSMTESQHLHTAQSVYKLLEPLLLQAYTIQPEQVSDQPADECLPVCVALGEFLQKISCGLSAEQEQGLLLLSLLRLFITTLKCPDSTFKGEPWWNPEKMETTTCCYLRLLCRLFDVVISGASQGPLAPCFRSLMQPLLQVHLNEPMVLFKFLSLSWGYNSNLGDQLDCRVSAILQTQALYVGKAFLSSQPVKTLNLLASDSSPVVPSLLVCVCSGVCEVRRAAIAVLQCLSGLVSSPYHPLVEKLLKSSEEIIADSSYLTQALSKFYEEAVSRKDKNKKLASVEQLLQCLQSPFCPSYTSKTLLRALQDVHGEPVLSVLLPAVERLLEQCAPDSCTFLPDEALLLQLLLSKFSEMSAPLLVKDPRCLEVFIRALHTSARPYPTIPSFQITALEQITKPFFTAIGDEKIQQKILSILFDLLVGNKSPACAQSINSVFKTIAVDCELVANELIPADKQRVTATVQQTRRSKMRKTQDTSGAVPEESVVSWPRVTLILELLQHKKKLKRAQYLVPALFNLLSRCLEPAAAEQENIEYTKQLILICLLNVCQKLSPEGGPISKDVLEEDKFNMELVVQCVRVSEMPQTHHHALLLLGALAGIFPEKVLHNIMPIFTFMGANIMRLDDTYSFQVINKTVQAVIPALIKAHEGGSSQSEGHMETVVAQIIHVFVDALPHVPEHRRLPILSQLMSTLGPSRFLWVLMLLLFKQHVTQTSAGATGAEKEAVVERDQDFWILVCCEFEVKEQLTSLIKILQYLMTLPQDREEAPEKKKPRGRSAVKKDETVSDLIFSVETHSGKDLRHFKFISISFMAQLLASDGFVGKVADCEDITESTLQALQQDLLVEVLRYIQAVARCVEDNADKPTAKFWRALLSKSYDTLDKVNALLPMDTFITVMRGLVGNQLASVRRKAMELLNNKLQQRTKWLKEQITALLELIGTLLSIVGRSHRQVTAQEEEELAINRQTALYSLKLLCRNFGSDHKEEFVPVLNKAVELVADKDEEKNVMGSALLCVAEVTSTLKALAIPQLHRLMPAVLDTLKERKDLLNNEIYLLSAVTALQRASETLPHFISPYLLDTILQVTRLTLLARRLTSCPQLSVRLASLSSTLATKLPPRVLIPTITKCYCSMVDAQQNRLSPLMNILKEHISHMDKDQLNNHQSELTSFFLSALDFRAQHCQGDLKKTAEIEGCVIDCLLVMIMKLSEVTFRPLFFKLFDWSKIDGASKDRLLTFYRLADRIADKLKGLFVLFAGQLVKPFSDLLHQLNISHTDKAFFDSEDESDDDSDEEADDNVTKSSLLLQYVLDCLHKIFLYDTQHFLSKERADALLCPLVDQLENMLGGEETYKSRITTHLVPCIAQFAVAMRDDSQWKVLNYQILLKTRHSSPKVRFSALVMLLELAGKLRENYMVLLPETIPFLAELMEDECEEVEHQVQKVIQEMETILGEPLQSYF
What is the function of this protein?
Ribosome biogenesis factor.  Involved in nucleolar processing of pre-18S ribosomal RNA.  Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (By similarity).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).  Required for cell survival in the CNS through its role in rRNA synthesis and processing.
What are the official names of this protein?
HEAT repeat-containing protein 1, Protein BAP28.
What is the protein family that this protein belongs to?
Belongs to the HEATR1/UTP10 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.