Protein: PFSYN_ROSSX
Sequence: MSNMAPLPTMGVEQQALSLSCPLLPHDDEKHSDNLYEQATRHFGLSRDKIENVLPCTSFQCDVIDCAVDDRRHAIGHVVYDIPNTVDIQRLAAAWKEVVRQTPILRTGIFTSETGDSFQIVLKEGCLPWMYATCLGMKGAVIQDEAVAAMTGPRCNRYVVLEDPSTKQRLLIWTFSHALVDYTVQERILQRVLTVYDGRDVECPRIKDTEHVSRFWQQHFEGLDASVFPLLPSHLTVCNPNARAEHHISYTGPVQRKWSHTSICRAALAVLLSRFTHSSEALFGVVTEQSHNSEDQRRSIDGPARTVVPIRVLCAPDQYVSDVIGAITAHEHAMRGFEHAGLRNIRRTGDDGSAACGFQTVLLVTDGDAPKTPGSVLHRSVEESDRFMPCANRALLLDCQMAGNSASLVARYDHNVIDPRQMSRFLRQLGYLIQQFHHHVDLPLVKELDVVTAEDCAEIEKWNSERLTMQDALIHDTISKWAAGDPNKAAVFAWDGEWTYAELDNISSRLAVYIQSLDLRPGQAILPLCFEKSKWVVATILAVLKVGRAFTLIDPCDPSARMAQVCQQTSATVALTSKLHNTTLRSVVSRCIVVDDDLLRSLPHADGRLKATVKPQDLAYVIFTSGSTGEPKGIMIEHRGFVSCAMKFGPALGMDEHTRALQFASYAFGACLVEVVTALMHGGCVCIPSDDDRLNNVPEFIKRAQVNWVILTPSYIGTFQPEDVPGLQTLVLVGEPISASIRDTWASQVRLLNAYGQSESSTMCSVTEVSPLSLEPNNIGRAVGARSWIIDPDEPDRLAPIGCIGELVIESPGIARDYIIAPPPDKSPFLLAPPAWYPAGKLSNAFKFYKTGDLVRYGPDGTIVCLGRKDSQVKIRGQRVEISAVEASLRRQLPSDIMPVAEAIKRSDSSGSTVLTAFLIGSSKSGDGNGHALSAADAVILDHGATNEINAKLQQILPQHSVPSYYIHMENLPRTATGKADRKMLRSIASKLLGELSQNVTSQPIEKHDAPATGIEVKLKELWFLSLNLNPNSQDVGASFFDLGGNSIIAIKMVNMARSAGIALKVSDIFQNPTLAGLVDVIGRDPAPYNLIPTTAYSGPVEQSFAQGRLWFLDQIELDALWYLLPYAVRMRGPLHIDALTIALLAIQQRHETLRTTFEEQDGVGVQVVHASPISDLRIIDVSGDRNSDYLQLLHQEQTTPFILACQAGWRVSLIRLGEDDHILSIVMHHIISDGWSIDILRRELSNFYSAALRGSDPLSVVSPLPLHYRDFSVWQKQVEQETEHERQLEYWVKQLADSSAAEFLTDFPRPNILSGEAGSVPVTIEGELYERLQEFCKVEQMTPFAVLLGAFRATHYRLTGAEDSIIGTPIANRNRQELENMIGFFVNTQCMRITVDGDDTFESLVRQVRTTATAAFEHQDVPFERVVTALLPRSRDLSRNPLAQLTFALHSQQDLGKFELEGLVAEPVSNKVYTRFDVEFHLFQEAGRLSGNVAFAADLFKPETISNVVAIFFQILRQGIRQPRTPIAVLPLTDGLADLRAMGLLEIEKAEYPRESSVVDVFRKQVAAHPHAFAVVDSASRLTYADLDRQSDQLATWLGRRNMTAETLVGVLAPRSCQTVVAILGILKANLAYLPLDVNCPTARLQTILSTLNRHKLVLLGSNATTPDVQIPDVELVRISDILDRPINGQAKLNGHTKSNGYSKPNGYTHLKGYSNLNGYSKQNGYAQLNGHRERNNYLDLNGHSLLNGNSDITTSGPSATSLAYVIFTSGSTGKPKGVMVEHRSIIRLAKKNRIISRFPSVAKVAHLSNIAFDAATWEMFAALLNGGTLVCIDYMTTLDSKTLEAAFAREQINAALLTPALLKQCLANIPTTLGRLSALVIGGDRLDGQDAIAAHALVGAGVYNAYGPTENGVISTIYNITKNDSFINGVPIGCAISNSGAYITDPDQQLVPPGVMGELVVTGDGLARGYTDPALDAGRFVQIMINDKAVRAYRTGDRARYRVGDGQIEFFGRMDQQVKIRGHRIEPAEVERAILDQDSARDAVVVIRHQEGEEPEMVGFVATHGDHSAEQEEADDQVEGWKDFFESNTYADMDTIGQSAIGNDFTGWTSMYDGSEINKAEMQEWLDDTMRTLLDGQAPGHVLEIGTGSGMVLFNLGAGLQSYVGLEPSRSAATFVTKAINSTPALAGKAEVHVGTATDINRLRGLRPDLVVLNSVVQYFPTPEYLLEVVESLVRIPGVKRVVFGDIRSHATNRHFLAARALHSLGSKATKDAIRQKMTEMEEREEELLVDPAFFTALLQGQLADRIKHVEILPKNMRATNELSAYRYTAVIHVRGPEEQSRPVYPIQVNDWIDFQASRIDRRALLRLLQRSADAATVAVSNIPYSKTIVERHVVESLDNNNRENTHRAPDGAAWISAVRSKAERCTSLSVTDLVQLGEEAGFRVEVSAARQWSQSGALDAVFHRYNLPTQSNSRVLIQFPTEDGQTRRSATLTNRPLQRLQSRRFASQIREQLKAVLPSYMIPSRIVVIDQMPLNANGKVDRKELTRRAQIAPKSQAAPAKPVKQVDPFVNLEAILCEEFAEVLGMEVGVNDHFFQLGGHSLLATKLVARLSRRLNGRVSVRDVFDQPVISDLAVTLRQGLTLENAIPATPDSGYWEQTMSAPTTPSDDMEAVLCKEFADVLGVEVSATDSFFDLGGHSLMATKLAARISRRLDVPVSIKDIFDHSVPLNLARKIRLTQAKGHEATNGVQIANDAPFQLISVEDPEIFVQREIAPQLQCSPETILDVYPATQMQRVFLLNPVTGKPRSPTPFHIDFPPDADCASLMRACASLAKHFDIFRTVFLEARGELYQVVLKHVDVPIEMLQTEENINSATRSFLDVDAEKPIRLGQPLIRIAILEKPGSTLRVILRLSHALYDGLSLEHILHSLHILFFGGSLPPPPKFAGYMQHVASSRREGYDFWRSVLRDSSMTVIKGNNNTTPPPPPQQQSTPSGAHHASKVVTIPTQANTDSRITRATIFTTACALMLAKEDNSSDVVFGRTVSGRQGLPLAHQNVIGPCLNQVPVRARGLNRGTTHHRELLREMQEQYLNSLAFETLGYDEIKAHCTDWPDVPATASFGCCIVYQNFDSHPDSRVEEQRLQIGVLSRNYEAINEGLVHDLVIAGESEPDGDDLRVTVVANRRLCDEERLKRMLEELCGNIRALALV
What is the function of this protein?
Nonribosomal peptide synthetase that synthesizes cyclooctadepsipeptides (CODPs) PF 1022 that show powerful broad-spectrum anthelmintic activity with low toxicity in animals (PubMed:10751395, PubMed:19072825).  Couples 4 N-methyl-L-leucines and a varying content of alpha-D-hydroxy acids (D-lactates or D-phenyllactates) in an alternative fashion (PubMed:10751395, PubMed:19072825).  The enzyme is capable of synthesizing all known natural cyclooctadepsipeptides of the PF1022 type differing in the content of D-lactate and D-phenyllactate, using from 4 D-lactates (PF 1022F) to 4 D-phenyllactates (PF 1022B), respectively (PubMed:10751395).  The formation of different PF-related compounds is mainly controlled by the molar ratio of the hydroxy acids (PubMed:10751395).  N-methylation of the substrate L-leucine takes place after covalent binding prior to peptide bond formation (PubMed:10751395).
What are the official names of this protein?
PF 1022-synthetase, PFSYN, Cyclooctadepsipeptide synthetase PFSYN, Nonribosomal peptide synthetase PFSYN.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.