PharMolix/UniProtQA huggingface dataset:
Protein: SUCC_COLP3
Sequence: MNLHEYQAKQLFAEYGLPVSEGFACDTPQEAAEAADKIGGDMWVVKTQVHAGGRGKAGGVKLVKSKEEIKEFAQHWLGKNLVTYQTDANGQPVAKILVESCTDIANELYLGAVVDRASQRVVFMASTEGGVDIEKIAEETPELIHQAEIDPLVGAQPYQARELGFKLGLNPTQMKQFVKIFMGLAKMFEDCDFALLEINPLVITDEGNLHCLDGKIGIDGNAIYRQPKMRAFHDPSQEDEREAHAAQWELNYVALDGTVGCMVNGAGLAMGTMDIVNLHGGKPANFLDVGGGANKERVSEAFKIILSDDNVKAVLVNIFGGIVRCDMIAEGIIGAVKEVGVKVPVVVRLEGTNAELGREVLKNSGLDIIAAESLTDAATKVVAAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: LDH2_LISIN
Sequence: MKPRKVMIIGAGNVGSAAAHAFVNQKFVEELILVDLNKERVEGNRKDLADAAAFMSGKMDISVREASDCADVDIAVITVTAGPLKEGQTRLDELRSTSRIVASIVPEMMKGGFKGIFLIATNPCDIITYQVWKLSGLPREQVLGTGVWLDTTRLRRLLAEKLDIAAQSIDAFILGEHGDSQFPVWSHSSIYGKPVNEYSMEKLGESLDLKLIGETARDTGFEIYHQKGCTEYGIAGTIVEICRHIFSGSQRALTVSCVLDGEYGQTGLAIGVPAVLSQNGVKEIISLKLNEQEQQAFDHSAAVIKENIKSI
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase 2, L-LDH 2.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT_CRYPV
Sequence: MSEEETQALVVDNGSGMVKAGVAGDDAPRCVFPSIVGRPKMPGVMVGMDQKDCYVGDEAQSKRGILTLKYPIEHGIVTNWEDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKVNRERMTQIMFETFNVPAMYVNIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYAIPHAIMRLDLAGRDLTDFLMKILHDRGYSFTTTAEREIVRDIKEKLCYIALDYEEEMKKSQESSELEKTYELPDGHVITVGSERFRCPEALFQPGFLGKEAVGIGETTFQSIMKCDLDIRKDLYANIVLSGGTTMYPGIGERMTKELTSLAPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQQMWITKEEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ATPF_SOLTU
Sequence: MKNVTDSFVSLGHWPSAGSFGFNTDILATNPINLSVVLGVLIFFGKGVLSDLLDNRKQRILNTIRNSEELRGGAIEQLEKARSRLRKVETEAEQFRVNGYSEIEREKLNLINSTYKTLEQLENYKNETIQFEQQRAINQVRQRVFQQALRGALGTLNSCLNNELHLRTISANIGMLGTMKEITD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NPL4_YEAST
Sequence: MLIRFRSKNGTHRVSCQENDLFGTVIEKLVGNLDPNADVDTFTVCEKPGQGIHAVSELADRTVMDLGLKHGDMLILNYSDKPANEKDGVNVEIGSVGIDSKGIRQHRYGPLRIKELAVDEELEKEDGLIPRQKSKLCKHGDRGMCEYCSPLPPWDKEYHEKNKIKHISFHSYLKKLNENANKKENGSSYISPLSEPDFRINKRCHNGHEPWPRGICSKCQPSAITLQQQEFRMVDHVEFQKSEIINEFIQAWRYTGMQRFGYMYGSYSKYDNTPLGIKAVVEAIYEPPQHDEQDGLTMDVEQVKNEMLQIDRQAQEMGLSRIGLIFTDLSDAGAGDGSVFCKRHKDSFFLSSLEVIMAARHQTRHPNVSKYSEQGFFSSKFVTCVISGNLEGEIDISSYQVSTEAEALVTADMISGSTFPSMAYINDTTDERYVPEIFYMKSNEYGITVKENAKPAFPVDYLLVTLTHGFPNTDTETNSKFVSSTGFPWSNRQAMGQSQDYQELKKYLFNVASSGDFNLLHEKISNFHLLLYINSLQILSPDEWKLLIESAVKNEWEESLLKLVSSAGWQTLVMILQESG
What is the function of this protein?
Substrate-recruiting cofactor of the CDC48-NPL4-UFD1 segregase (PubMed:31249135).  Assists CDC48 in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation (PubMed:11739805, PubMed:11740563, PubMed:11847109).  Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus (PubMed:8930904, PubMed:11733065).  Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1 (PubMed:11733065).  Regulates ubiquitin-mediated mitochondria protein degradation (PubMed:31249135).  Involved in spindle disassembly probably by promoting the degradation of spindle assemby factors ASE1 and CDC5 at the end of mitosis (PubMed:14636562).
What are the official names of this protein?
Nuclear protein localization protein 4, HMG-CoA reductase degradation protein 4.
What is the protein family that this protein belongs to?
Belongs to the NPL4 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane.
Protein: SPED_ECOLI
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPKLIDKTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDINGMKHFIDHEINSIQNFMSDDMKALYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTDSERQEITAALWKEMREIYYGRNMPAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: CNBD1_HUMAN
Sequence: MPMSSLPAAILSHMTAINNVPPPPLHSIPNLKKSKHINYGQLNALCHIRGQHSRSMSNILSAHDTFMKQYPKVFLHQKPRLPKLFKQEEQRELNEGKEESQHQQPDDSNNIAVHVQRAHGGHILYRPKRATEKFEEFLAILKKLPIHRTPYEHKTVWKFLKTIPDLTFQLNDKHLKTLSKTVFSETWLKGSTVVANDGFYVILKGLARPQTNVYKNLIEGSDSPDSFISQSFHSFIWSEEFKNSTLAEMYLPSYDSMLSKWSTFGTLEVMPQNESETQMFSVVTEDDCEILKIPAKGYAKIKEEKIKLENMQKLKLIRMCPYYEEWPTLSIYELIALLKWKKFPPGHVIVESGNIISFVGYINSGCCNIYRSIIGFVKLRSNKVKRSQKLVYMGKLKEKESFGEISVLLQVPFTCTIITKKEVEMAIIEDKDLFVA
What are the official names of this protein?
Cyclic nucleotide-binding domain-containing protein 1.
Protein: SYFA_ECO45
Sequence: MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKAELESAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDATRLLRTQTSGVQIRTMKAQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMGY_SCHPO
Sequence: MTTEAAPNLLVLTRHGESEWNKLNLFTGWKDPALSETGIKEAKLGGERLKSRGYKFDIAFTSALQRAQKTCQIILEEVGEPNLETIKSEKLNERYYGDLQGLNKDDARKKWGAEQVQIWRRSYDIAPPNGESLKDTAERVLPYYKSTIVPHILKGEKVLIAAHGNSLRALIMDLEGLTGDQIVKRELATGVPIVYHLDKDGKYVSKELIDN
What are the official names of this protein?
Phosphoglycerate mutase, PGAM, BPG-dependent PGAM, MPGM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: COAX_STRAW
Sequence: MLLTIDVGNTHTVLGLFDGEDIVEHWRISTDARRTADELAVLLQGLMGMHPLLGEELGDGIDGIAICSTVPSVLHELREVTRRYYGDVPAVLVEPGIKTGVPILMDNPKEVGADRIINAVAAVELYGGPAIVVDFGTATTFDAVSARGEYAGGVIAPGIEISVEALGVRGAQLRKIELARPRAVIGKNTVEAMQAGIVYGFAGQVDGVVTRMARELADDPDDVTVIATGGLAPMVLGEASVIDEHEPWLTLIGLRLVYERNISRT
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTR2_RAT
Sequence: METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
What is the function of this protein?
Receptor for the tridecapeptide neurotensin.  It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Neurotensin receptor type 2, NT-R-2, NTR2, High-affinity levocabastine-sensitive neurotensin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NCLN_CAEEL
Sequence: MQDEIIDFFRSPALLFYMTLMLTICVVNGSQQVGEVVETEFHAYRLHQYEISGNIYGCKNYRVSYEAVSLGARTLRRTMVTTWRDLLTTDVDDMWALSTGAVLIFIPDNLDELNDIDRKAFIDLEAKLLSAKTDLAVYVAPFNDDAVSILHDVNTRSEKAPTALQHLLQSLSGNTISITSSDQSPELPPSYKPLNIVGRLSSGDRAAPTIAFVAHYDTQSAVPGVSPGADSNGSGIVALLELLAVLSKFYDSPSTRPPYNILFIWTAAGKLNYQGTRHWIDEYQKGFDSADYAKSGLSRKGFSDDRVDLAICIEAIGRKTGGFFMHAGKTPSENSVAAQLLRRLKYFSSISPKKNIELVTKKISLTTVSAWEHEKFNIKRMPAITLSTLPSPSDPARNSILDLPSALDEDELIDNIRLIGEAVLGYILDLPESGPSSDSRVKSEATMLSKDAVDKQRVHHFIRQFASRPRPVGDQRATESITSNLASVAAGYGNVFKSAVTITDAKAFGVTQNRLVAERVKPAVFELVIAAGVFTYLSAFYYIATHSQNTIEGTVAAIRKSIF
What is the function of this protein?
Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER) (PubMed:19609303, PubMed:24567339).  In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER (PubMed:19609303).  Specifically, may promote the inclusion of alpha subunits unc-38 and unc-29 into L-AChR (PubMed:19609303).  Regulates L-AChR sensitivity to agonists such as nicotine and levamisole at neuro-muscular junctions (PubMed:15990870, PubMed:19609303).  In touch neurons, may prevent ER exit of incorrectly folded mec-4-mec-10 ion channel (PubMed:24567339).
What are the official names of this protein?
Nicalin, Inactive aminopeptidase nra-2, Nicotinic receptor-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the nicastrin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=During the assembly of acetylcholine receptor in muscles, colocalizes with L-AChR component unc-29 in the ER.
Protein: RIMM_STRS7
Sequence: MEYFNVGKIVNTQGLQGEMRVLSVSDFTEERFQKGARLALFDDKDRFVQEVEIASHRKHKQFDIIKFKGMYHINAIEQFKGCSLKIAKEHQGKLAEGEFYYHQIIGLEVYEKDQLVGQIKEILQPGANDVWVVKRQSKRDLLLPYIPSVVLGVDIEKGRVDVEIMEGLDDED
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMC2_YEAST
Sequence: MKVEELIIDGFKSYATRTVITDWDPQFNAITGLNGSGKSNILDAICFVLGIASMSTVRASSLQDLIYKRGQAGVTKASVTIVFDNTDKSNSPIGFTNSPQISVTRQVVLGGTSKYLINGHRAPQQSVLQLFQSVQLNINNPNFLIMQGKITKVLNMKPSEILSLIEEAAGTKMFEDRREKAERTMSKKETKLQENRTLLTEEIEPKLEKLRNEKRMFLEFQSTQTDLEKTERIVVSYEYYNIKHKHTSIRETLENGETRMKMLNEFVKKTSEEIDSLNEDVEEIKLQKEKELHKEGTISKLENKENGLLNEISRLKTSLSIKVENLNDTTEKSKALESEIASSSAKLIEKKSAYANTEKDYKMVQEQLSKQRDLYKRKEELVSTLTTGISSTGAADGGYNAQLAKAKTELNEVSLAIKKSSMKMELLKKELLTIEPKLKEATKDNELNVKHVKQCQETCDKLRARLVEYGFDPSRIKDLKQREDKLKSHYYQTCKNSEYLKRRVTNLEFNYTKPYPNFEASFVHGVVGQLFQIDNDNIRYATALQTCAGGRLFNVVVQDSQTATQLLERGRLRKRVTIIPLDKIYTRPISSQVLDLAKKIAPGKVELAINLIRFDESITKAMEFIFGNSLICEDPETAKKITFHPKIRARSITLQGDVYDPEGTLSGGSRNTSESLLVDIQKYNQIQKQIETIQADLNHVTEELQTQYATSQKTKTIQSDLNLSLHKLDLAKRNLDANPSSQIIARNEEILRDIGECENEIKTKQMSLKKCQEEVSTIEKDMKEYDSDKGSKLNELKKELKLLAKELEEQESESERKYDLFQNLELETEQLSSELDSNKTLLHNHLKSIESLKLENSDLEGKIRGVEDDLVTVQTELNEEKKRLMDIDDELNELETLIKKKQDEKKSSELELQKLVHDLNKYKSNTNNMEKIIEDLRQKHEFLEDFDLVRNIVKQNEGIDLDTYRERSKQLNEKFQELRKKVNPNIMNMIENVEKKEAALKTMIKTIEKDKMKIQETISKLNEYKRETLVKTWEKVTLDFGNIFADLLPNSFAKLVPCEGKDVTQGLEVKVKLGNIWKESLIELSGGQRSLIALSLIMALLQFRPAPMYILDEVDAALDLSHTQNIGHLIKTRFKGSQFIVVSLKEGMFANANRVFRTRFQDGTSVVSIM
What is the function of this protein?
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.  The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
What are the official names of this protein?
Structural maintenance of chromosomes protein 2, DA-box protein SMC2.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Protein: AROK_PSEAE
Sequence: MVNLILVGPMGAGKSTIGRLLAKELHLAFKDSDKEIEQRCGANIPWIFDVEGEVGFREREQAMLTELCAADGMVIATGGGAVMRDGNRQVLRAGGRVVYLHASVEHQIARTARDRNRPLLQKPNPGQILRDLMALRDPLYREIADVVVETDERPPRLVVQEILERLRKLPPR
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RURE_PSEPU
Sequence: MAIVIVGAGTAGVNAAFWLRQYGYKGGIRLLSRESVTPYQRPPLSKAFLTSETAESAIPLKPESFYTNNNISISLNTQIVSIDVGRKVVAAKDGEEYAYEKLILATGASARRLTCEGSELSGVCYLRSMEDAKNLRRKLVESASVVVLGGGVIGLEVASAAVGIGRRVTVIEAAPRVMARVVTPAAANLVRARLEAEGVGFKLNAKLTSIKGRNGHVNQCVLESGEKIQADLIIVGIGAIPELELATEAALEVSNGVVVDDQMRTSDTSIYAIGDCALARNLFFGTMVRLETIHNAVTQAQIVASSICGTSTPAPTPPRFWSDLKGMTLQGLGALKDYDKLVVAINNETVELEVLAYKQERLIATETINLPKRQGALGGSIKLPD
What is the function of this protein?
Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
What are the official names of this protein?
Rubredoxin-NAD(+) reductase, RdxR.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_SHEAM
Sequence: MSKRTFQPSNLKRKRSHGFRARMATANGRKVLARRRAKGRARLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: TUSD_ECO8A
Sequence: MRFAIVVTGPAYGTQQASSAFQFAQALIVEGHELSSVFFYREGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALNICVAAALRRGIVDETEAGRLGLASSNLQPGFTLSGLGALAEASLTCDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_OENOB
Sequence: MNDIPAIGSPIRTRTILNEYDLHASKRLGQNFLIDLNVLQEIVQGAAIGPDDTVIEIGPGIGSLTEQLAKAAKQVVAYEIDKKLIPILSETLRPYKNVEIVNRDILKADFSIFAKNQSLKIVANLPYYITTPILFYLLNSSLNFKSVTVMMQKEVAARLQAGVGSKDYGELSLAIQYRVNVEIILPVTRKSFMPSPNVDSAIVQLTPKENFQSFPHEEALFKIIKASFAHRRKSLVNNLLYYFGKNDENRTKIERSISETGFDLNIRGERLTLENYEQLVNNLSENMIFSKE
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AOXA_MOUSE
Sequence: MDPIQLLFYVNGQKVVEKNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKAIRHHPVNACLTPICSLHGTAVTTVEGLGNTRTRLHPIQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFCKASACCQSKENGVCCLDQEINGLAESQEEDKTSPELFSEEEFLPLDPTQELIFPPELMRIAEKQPPKTRVFYGERVTWISPVTLKELVEAKFKYPQAPIVMGYTSVGPEVKFKGVFHPIIISPDRIEELGVISQARDGLTLGAGLSLDQVKDILADIVQKLPEEKTQTYRALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLNLLSKDGERRIPLSEEFLRKCPEADLKPQEVLVSVNIPWSRKWEFVSAFRQAQRQQNALAIVNSGMRVLFREGGGVIEELSILYGGVGSTIISAKNSCQRLIGRPWNEGMLDTRCRLVLDEVTLAASAPGGKVEFKRTLIISFLFKFYLEVSQGLKREDPGHSPSLAGNHESALDDLHSKHPWRTLTHQNVDPAQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITADHLQEANTFGTETFLATDEVHCVGHLVCAVIADSETRAKQAAKQVKVVYQDLAPLILTIEEAIQHKSFFKSERKLECGNVDEAFKIVDQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKYIQDIVAATLKLSANKVMCHVRRVGGAFGGKVGKTSILAAITAFAASKHGRAVRCILERGEDMLITGGRHPYLGKYKAGFMNEGRILALDVEHYCNGGCSLDESLWVIEMGLLKLDNAYKFPNLRCRGWACRTNLPSNTALRGFGFPQAGLVTEACITEVAIKCGLSPEQVRTINMYKHVDTTHYKQEFSAKALSECWRECMAKCSYFERKAAIGKFNAENSWKKRGMAVIPLKFPVGIGSVAMGQAAALVHIYLDGSALVSHGGIEMGQGVHTKMIQVVSRELRMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQTAFDQSISLSAVGYFRGYESNIDWEKGEGHPFEYFVFGAACSEVEINCLTGDHKNIRTNIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQGTLYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVKAARQERGISGPWKLNSPLTPEKIRMACEDKFTKMIPRDEPGSYVPCNIPV
What is the function of this protein?
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin.  Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents.  Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent.  Also plays a role in the reductive metabolism of the xenobiotic imidacloprid (IMI) via its nitroreduction to nitrosoguanidine (IMI-NNO) and aminoguanidine (IMI-NNH(2)).  Is probably involved in the regulation of reactive oxygen species homeostasis.  May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen.  May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor.  May play a role in adipogenesis.  Cannot use xanthine and hypoxanthine as substrate.
What are the official names of this protein?
Aldehyde oxidase 1, Azaheterocycle hydroxylase 1, Retinal oxidase.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHE9_NEUCR
Sequence: MSSTTAIRLAARPSSWRGTGALSSGRPLSQFASLPRRSINPSISGMRQGTLRLSIHDGRLFFSTQPPKDTPENMNNKETGSSNVIFMPPPPPAQTEAPSSGSAKEDTTDATNKSETETPTAASESETSKSSESDVSSASTSDSANSSETTTTTSETTPENGNNDTAQPELPSRTEAHRARLSARFSTIMDNFQTRLLTATQTLNDLTGYSAIEQIKRKNAELEVAHGQAQSRLRDARHNYKSLTMHRASTQREVTTLLARKDTWNPLDLERFTSLYRLDHELEAQVAQAAQELTEAETEESRLSADLNAGILKRYHEEQIWSDRIRRQSTWGTWGLMGVNVLLFLVLQFVAEPWRRKRLMKGIAENEKGVIDEVRHELGQVRQALEASGLRETAHLARLMEQEREIQALASTSSSSGDPQGGGGRTEGEVEMDIGAEFMAAAAEEAAEEAATAQQQQQQQQQQQQQQHHQTPETQEEPQQPPLTWKQTAQKWQQTLSDPQQIKAAVVDLYSDRRIDLKMRDVSLLALESAATGAAVVASVAFFVLRSSGSGKA
What is the function of this protein?
Required for the maintenance of the structure of the mitochondrial inner membrane.  Involved in mitochondrial morphology.  Causes growth arrest when highly overexpressed (By similarity).
What are the official names of this protein?
Sensitive to high expression protein 9 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the SHE9 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SYA_SACEN
Sequence: MQTHEINQRFTEHFRKAGHTVVPSASLILDDPTLLFVNAGMVQFKPYFLGDAPAPYPRATSIQKCVRTGDIDEVGKTTRHNTFFQMAGNFSFGDYFKEGAMEHAWGLLTSSQADGGYGFDPERLWVTVFEKDEEAAALWQKVTGIPAERIQVRDAKDNYWDMGVPGPGGPCSEIYYDRGPKYGREGGPVVDEDRYIEIWNLVFMQDIRGELPPKEGHPPIGELPTKNIDTGMGVERVACLLQGVENVYETDLVRPVIAKAEELSGRSYGANHEDDVRFRVIADHARSGVMLVGDGVTPGNEARGYVLRRLLRRIIRSTRLLGVHEPVLGEFAAVVRDAMAPSYPELVTEFDRIDSVMRNEEDAFLSTLTAGSKIFDLAVADTKKAGGTQLAGAKAFQLHDTYGFPIDLTLEMASEQGLSVDEHGFRELMSEQRRRAKEDAKSRKSGHGDLSTYRTLLDQHGTTEFLGYTDLQAQSRVLGLLVDGVPAKSAAAGTEVELILDRTPFYAEGGGQIADTGRLTGPGVEVEVHDVQRAVPGLFVHRAKVTAGELGVDTSLEAAVDSKRRHAIERSHSATHLVHAAVRSAYGKRAAQAGSLNSPGRMRFDFTAPAAVSGAVLGGVEEEVNSYLQNDVEVQSYTTTMDRAMELGAVALFGEKYGDQVRVVDMGDYSRELCGGTHVGRIGQLGVVKLVADSSVGSGVHRVEALVGMDAMRHISKEHLLVSRLAEQFKVPAEELPERIAGVVSRLRSAEKELEQLRVAQVLQSAGELAGKGTDVHGVTLVAEQVPDGVDGGALRALAGEVRGRLGSRPAVVALFSADGDKVSFVVGVNTPAQDLGLKAGKLVPSFAAEVGGRGGGKPDMAQGGGSNPAGITAAIAALRTGLDQAVARG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB2_SACS9
Sequence: MVIMGNELQLENKILKGTTTVGIRVNDGVILAADRRASAGFFVANKMVRKVLYITDKIGITTAGSVADLQFIYDVLKNIYHYNSITKYGPISIKGIATRLANVLSATKYFPYIVQILIGGYDDQPRLFNLDYLGDITEENYVATGSGSPVAMGVLEDEYNPKMTLDEAADLAKRAVFSAIKRDSFTGTGVIVAKIHSKGHEELEFYLNKKM
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 2, 20S proteasome beta subunit 2, Proteasome core protein PsmB 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.