PharMolix/UniProtQA huggingface dataset:
Protein: SSRA_HUMAN
Sequence: MRLLPRLLLLLLLVFPATVLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGETIFMYMFLAGLGLLVIVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSWIPQETLNQINKASPRRLPRKRAQKRSVGSDE
What is the function of this protein?
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.  May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
What are the official names of this protein?
Translocon-associated protein subunit alpha, TRAP-alpha, Signal sequence receptor subunit alpha, SSR-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAP-alpha family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: Y3697_CUPMC
Sequence: MTDTPDTPDTPMATGASSRPPLRALTPLEGRVVAVLLEKQFTVPDTYPLSLNALAAGCNQKTARSPVMSVGEDEILTAIDGLKSLSLVFEGSSSRVPRFEQNLARVLGVPSQSAALLSTLLLRGPQTAAELRLNTARLHAFADISSVEAFLDELAERDPALVVKLPRGPGEREHRWTHLLCGEVSLAEAPGLRTSASIEIAPSELEALRISHRELEDKVARLQALVEEMAEQLGISIDPDRLS
What are the official names of this protein?
UPF0502 protein Rmet_3697.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: RS13_BRUA4
Sequence: MARIAGVNIPTNKRVVIALQYIHGIGPKFAREIVTKVGIADDRRVNQLSDAEVLQIREAIDADYQVEGDLRREVSMNIKRLMDLGCYRGLRHRRSLPVRGQRTHTNARTRKGPAKAIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: YCF78_TUPAK
Sequence: MFFANALKDYIDQLNDLTILLNDNFTVFTFLKSLIIYLFDSIKFVFIYLVSCKWLTDFIELPCTFKSNYTAILEGKSILETNVTPSFFHFLETKPLTSNSFLTGFLNSFFLTLPFSVPHLLSLRAFLINGLPAGISAALGTILGQFTFFICVFFGFEGILIPFLTFEPLNYILGFVIVVNVLYNMAHKPNMEVLNKSQLTILSKFFGLNFVLSWTEQTSLFHYCGNLTFNNVPTLLQSAEEGVSKLNGITTFFLPNFLYLVGILLGSFLWTALLGFLFTIFRNGLSRVLTIPFMFLNDKIHKFIFVLTFTFCLTSIPYYGFDYLVSAPLGFIGQDRALEFFKAKPYYQIATPAKDKVYGEVFLNPIPFDRTGQLELQLSEKPVATFEDYSVDSENAWRNRQKRRPQNTKLQSTQTSRKTFENKERNQDQTFIETFYKSIKITEKSKLSKVEKDIDQIASKLFNPIAYDYYDQGMDHSPYTRKLFREKFYNNPVYKSFVHLDMISFLQGQPESYNLTAIDEAALYRRRFLLENYLASIHDYKDLILKKQTNNSYAENVYNQQFKGSLDLVRHYFSISLTSDINQFDSFGSLLLSDNQKTKKILKFDQPLYKNYLQESNPILHEELDLEVKTNLLQNSVKKKKTELFKKDREVTLTQSKEETEATPFYIGWDGTLRKFLVKKACTPGIPFGNEAFSKNPTPYLPTGLPTYLSFQSWPLNLNENNFKSIFDKGVSIPYTPLSKENALKVAELFELENFKFDHANLSNLLQNQNLPLYNWNILLGNSKDPLLPKNLNAYIDLGNTLPPQFGGFAWPGETIKLPGFLNFLNSNKNDSSF
What are the official names of this protein?
Uncharacterized membrane protein ycf78, ycf1.
What is the protein family that this protein belongs to?
Belongs to the ycf78 family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: AGTR2_MOUSE
Sequence: MKDNFSFAATSRNITSSRPFDNLNATGTNESAFNCSHKPSDKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLALADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKGSSLREMDTFVS
What is the function of this protein?
Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8726696).  Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways (By similarity).  Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15539617).
What are the official names of this protein?
Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VPS10_AJECH
Sequence: MILRRLLLAGSLLLATAFTSAKKADGPKISVTKFKDEPVNLFYFDDSDTVMFQDGKNGDVYVSRDAGANWDIVDVSGMRGKAWSLLPHPTDRTKAYIMSNGGTHWVTEDQAKSWREFTVDADLSRYEYPLVFHGKDSNRVMLLGHKCNGLDCKEKTYYTTDGFKTAHLLMENGRHCAWAVSTPTFGEGLDLPKEVNDRIFCVVSGLHSSWAEANRLLYSDRFFKDEQGTEVPLDNGRAVSGVIRTASVQKYILAATKSARTNELALFVTDNASTWHRTEFDGHRVEEDAYTILESTSYSLQVDVVSTYSSTIGTLFTSNSNGTYFTRNIEHTNRNMYGFVDFEKISSIQGIILVNTVKNWEDVEKSNGVQKKVISKISFDDGRTFQPLKVGKHDLHLHSVTDATNSGRVFSSPAPGLVMGVGNTGGHLKDYLDGDLFVSDDAGINLEEKLWTMLINMNSVIKASNWHKASLPDGVQIRAKVLTTAPGSTTLKFLLLGSAKADIGMEYYIISIDFAEMEDALVRRKTSKIGCQIERENEPDADGHKHPDAPEGVCKNPDDKFTGSSGFRLIPGNVCIREGGVDLDKQTERVCSETFKNPPAGQIVVEKSFFTADYYKDYFYLERKESSKGEDETVIMITSEQQIFLSRDHGKKWKQILEEEKITRIEPHRFFDDVAYFLTNNGDGWYTLDRGDTFRKFKAPLPPNQDKLPVLSFHPDRRDWLIWTGADECNGNGGNCHSVAYYTTNLGGEWHFLMRYVRRCEFISRDARGSSDKLVFCEQFENENPSNKHLQLLSTEDWFAEKRLHYSNILDFATMQEFIIVAIRGENSQDSLRIGVSIDGKTFADAELPANVQIPIQRAYTVLESRTHAAFLHVTINNIEDHEYGSIIKSNSNGTSYVLSLSAVNRNSRGYADFEKMQGLEGVAMANVVGNVADVENGAAKKFRTMITHNDGAEWTLMRPPDKDSEGRSYACSTKGGKPTDACALHLHSYTERADPRDTYSSPSAVGIMIGTGNVGDYLSLKSKADTFITRDAGITWEEVKKGKYQWEFGDSGSIIVLVPESTPTKTLLYSLDEGRSWKDFEFSEVEMQIQDISTVPSDTSRNFLLWGKEVGQGKKPGIATVNIDFSGLKERSKQCVLDEKKPEADDYYLWEPKHPLQPNGCLFGHRAKYHRKRPDKDCYNGRELQHLDSIGDICECTRSDYECDYNYEPQSDGSCARVAGLEPLDPKLVCTENPKAVEWYEPTGYRRIPLTKCQGGKQLNHIVAHPCPNKEEEFFKKHPRLRGIGLFFVILIPICLAATAGYYVYNHWDGKFGRIRLGETGSGGLFDRDSLLVSIPVSMVAGVVAVITALPLLVSSLWRSVSGYVRVPGGASSRRPYSSRDSFAARRSDYVGVVEDEDELLGTDDFDDDEEGDERNGQV
What is the function of this protein?
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.  Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
What are the official names of this protein?
Vacuolar protein sorting/targeting protein 10, Carboxypeptidase Y receptor, CPY receptor, Sortilin VPS10, Vacuolar carboxypeptidase sorting receptor VPS10.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Protein: ISPE_BUCAI
Sequence: MIYTCLSPAKINLFLYVTGRRKDGYHNIQTLFQFLDYGDQFKIIANKTGNIELFTEKKIFMNVQNSIIIAAKLLKKTALLQGKLQNSSYGAKIFLKKNIPMGSGLGGGSSNAATTLVVLNKLWNTQYTLKELSLLGLRIGADVPGFVMGNTAVIEGIGDILYPIVQKEKWYLVVYPCINISTRYMFSSPFLMSNTAKKSLQVLLKTPFKNDFENIAKKQFVPIKKLIRMLSSYAPSRMTGTGSCVFSEFDNKKSAQKIFSVLPKNVQGFIAKSVNISPLHKTLYKR
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: YDAJ_BACSU
Sequence: MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPAEYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFLMSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYNMNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNGFLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGRYSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGYMSGTQTHSFDNLLPLLAERKLFNENIIQ
What are the official names of this protein?
Putative lipoprotein YdaJ.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: YRKN_BACSU
Sequence: MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDGPIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQGIGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRNGREDDKPLLNDDDFFRFVKIMKKKD
What are the official names of this protein?
Uncharacterized protein YrkN.
Protein: ASL2_SARSH
Sequence: MAAPSLESNWLVQIPNQSGSHVAQARKDSFAEHMSYNKTHIEAGRMVLAGPLVEALPQDGQPPVITGSIMVWKATAGEREMLDKWLSDNPFATSGVWDLTKMECTPFLCGVRKGL
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of xenovulene A, an unusual meroterpenoid that has potent inhibitory effects on the human gamma-aminobutyrate A (GABAA) benzodiazepine receptor (PubMed:29773797).  The first step of xenovulene A biosynthesis is the biosynthesis of 3-methylorcinaldehyde performed by the non-reducing polyketide synthase aspks1 (PubMed:17912413, PubMed:29773797, PubMed:20552126).  The salicylate hydroxylase asL1 then catalyzes the oxidative dearomatization of 3-methylorcinaldehyde to yield a dearomatized hydroxycyclohexadione (PubMed:29773797).  The 2-oxoglutarate-dependent dioxygenase asL3 further catalyzes the oxidative ring expansion to provide the first tropolone metabolite (PubMed:29773797).  The cytochrome P450 monooxygenase asR2 allows the synthesis of tropolone hemiacetal (PubMed:29773797).  In parallel, a previously unrecognised class of terpene cyclase, asR6, produces alpha-humulene from farnesylpyrophosphate (FPP) (PubMed:29773797).  The putative Diels-Alderase asR5 probably catalyzes the formation of the tropolone-humulene skeleton by linking humulene and the polyketide moiety (PubMed:29773797).  Oxidative-ring contractions catalyzed by asL4 and asL6 then processively remove carbon atoms from the polyketide to yield xenovulene A (PubMed:29773797).
What are the official names of this protein?
Xenovulene A biosynthesis cluster protein asL2.
Protein: T23O_DROSE
Sequence: MSCPYAGNGNDHDDSAVPLTTEVGKIYGEYLMLDKLLDAQCMLSEEDKRPVHDEHLFIITHQAYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYNQKYSDVFSDEEARNSIRNSEKDPSLLELVQRWLERTPGLEETGFNFWAKFQESVDRFLEAQVQSAMEEPVEKAKNYRLMDIEKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIRKKLINKSV
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Protein vermilion, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: NACA_ASPFU
Sequence: MADPRVEELPDEEVPKANVEDAGSDSESEAGEESSIPAGAAVTIHSRNEKKARKAIGKLGLKHVPGITRVTLRRPKNILFVINQPDVYRSPSSNTWIIFGEAKIEDLNSQAQASAAQQLAAAEAAAGEHAGHDHDHDHGKGKAPETEAKKEEEEDDGEEVDETGLEAKDIELVMAQANVSRKKAVKALRENDNDIVNSIMALSI
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  Egd2 may also be involved in transcription regulation (By similarity).
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: PVK1_PSEFV
Sequence: GASGLIPVMRN
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, PseFl-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMFO_RHOPA
Sequence: MTSRTAPASPVVHVIGAGLAGSEAAWQIARAGVRVVLHEMRPVRTTEAHKTDGLAELVCSNSFRSDDAANNAVGLLHAEMRRLGSLIMQAADANQVPAGGALAVDRDGFSAAVTKALAEHPLIEICREEIDGLPPQEWTNVVIATGPLTSAPLADAIRGLTDESALAFFDAIAPIVHRDSIDMSVAWFQSRYDKVGPGGTGADYLNCPMTREQYDAFVDALIEGEKVDFKDWEKDTPYFDGCLPIEVMAERGRETLRHGPMKPVGLTNPHNPTVKPYAIVQLRQDNKLGTLYNMVGFQTKLKHGAQLRVFRTIPGLENAEFARLGGLHRNTFLNSPKLLDESLRLRASPRLRFAGQMTGCEGYVESASIGLFAGLAAAADLVGQSLAPPPPTTALGALLGHITGGHIETIDAGPRSFQPMNINFGLFPPLANPPTKGPDGKRLRGPEKSVAKKQALSARALADIDAWIAAHLKLPKAA
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POLG_WMV2U
Sequence: LSVTRKQCLELGMVLSLSPMGTYLEGTMGCLQLKHGHGGFVIHNTTQLRIHFIQGKDAILIRMPKIFLRLQSATSLDNQNVRNEFAWLEQTFKRRAYGQQSQSSSIILPEGKGSFWIHWITTQDGFCGLPLVSVNDGHVVGIHGLTSNDSEKNFFVPFTDGFEKEYLDNADNLSWDKHWFWEPSKIAWGPLNLVEEQPKEEFKISKLVSDLFGNTVAVQSRKERWVLDAMEGNLVACGQADSALVTKHVVKGKCPYFAQYLSLHDGAXQFFEPLMGAYQPSRLNKDAFKKDFFKYNKPVVLNEVDFNAFEKAVEGVITMMVDFEFAECLFVTDPDEIYGSLNMKAAVGAQYKGKKQDYFSGMDSFDKERLLYLSCERLFNGEKGIWNGSLKAELRPIEKVQANKTRTFTAAPLDTLLGAKVCVDDFNNQFYSFNLKCPWTVGMTKFYGGWDKLMRSLPDGWTYCHADGSQFDSSLTPLLLNAVLSIRCCFMEDWWVGREMLENLYAEIVYTPILAPDGTIFKKFRGNNSGQPSTVVDNTLMVVIAMYYSCCKQGWSEEDIERRLVFFANGDDIILAVKDEDVWLYDTLSASFAELGLNYNFDERTKKREELWFMSHQAMLVDGIYIPKLEPERIVSILEWDRSKELMHRTEAICAAMIEAWGYTELLQEIRKFYLWLLSKDEFKELAASGKAPYIAETALRKLYTDVNTQPSELQRYLEVLDFNHIDGCCESVSLQSGKETVENLDAGKESKKDASDKGNKPQNSQVGQGSKEPTKTGTVSKDVNVGSKGKEVPRLQKITKKMNLPTVGGKIILSLDHLLEYKPSQVDLFNTRATKTQFESWYSAVKVEYDLNDEQMGVIMNGFMVWCIDNGTSPDVNGVWVMMDGEEQVEYPLKPIVENAKPTLRQIMHHFSDAAEAYIEMRNSESPYMPRYGLLRNLRDRELARYAFDFYEVTSKTPNRAREAIAQMKAAALAGVNSRLFGLDGNISTNSENTGRHTARDVNQNMHTLLGMGPPQ
What is the function of this protein?
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae genome polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein]: Virion.
Protein: MT1H_HUMAN
Sequence: MDPNCSCEAGGSCACAGSCKCKKCKCTSCKKSCCSCCPLGCAKCAQGCICKGASEKCSCCA
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
What are the official names of this protein?
Metallothionein-1H, MT-1H, Metallothionein-0, MT-0, Metallothionein-IH, MT-IH.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: NUOH_COXBU
Sequence: MTDQLITLIWIIIKIVLILVPLLVAVAFITLAERKVIGYMQSRVGPNRVGFRGLAQPIADIFKLLLKEVIIPTASSRYLYLIAPILSLVPALAAWAVIPFAQGWVLANVNAGLLFLFAMTSLGVYGILVAGWASNSKYAFFGALRSAAQVVSYEIPMGFALVGVLLAAGTMNLQGIVLRQSGGLWHWFWLPLLPLFVTYWITAVAETNRAPFDVAEGESEIVAGFHVEYAGVTFALFFLAEYANMVLVSAIATVIFLGGWLSPFQGIPGLESLFAWVPGIVWFVLKLSLFIFTYFWMRATFPRYRYDQIMRLCWKVLIPVTLVWIIILALAIEFHWTHWL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTNN_SHEDO
Sequence: MKIGIIGAMEPEVAHLIQSLTSAEHSLIAGIEFISGQIAGKDVVITRSGIGKVAASIATTLLIEKFAVTQVVNTGSAGGFVDSLKIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFIPDAALVEAAKKAVSALGEVKAIEGLICTGDSFICDPERTKVMRANFPTMAACEMEGAAIAQVCHQFKVPFVVIRSLSDNANNDSPVDFDSYIIKAGHHSAMMVVALLTEL
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: EUTC_PSEA8
Sequence: MNDKHLPDASAENPWLPLRQLTPARIALGRTGTSLPTRPQLDFQYAHAQARDAVHLPFDHAAISDGLRQRGRDSLLLHSAAADRHVYLQRPDLGRRLDEASVQRLREHAAGYDGQIDLAIVVADGLSALAVQRHTLPFLERLEEQALAEGWSLSPVVLVEQGRVAVADEIGELLRAKMSVILIGERPGLSSPDSLGLYFTWAPRVGLTDAYRNCISNVRLEGLSYGMAAHRLLYLMREACRRQLSGVNLKDEAEVQALDGEAPRTGNFLLARD
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: COAX_MYCSJ
Sequence: MLLAIDVRNTHTTVGLISGSGDHAKVVQQWRIRTESEATADELALTIDGLIGEDSERLTGAVGLSTVPSVLHEVRLMLEQYWPSVPHVMIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYHRFGTAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELTRPRSVIGKNTVECMQSGALFGFAGLVDGLVNRIREDVAGFSGTDVAVVATGHTAPLVLPDVHTVAHYDRHLTLDGLRLVFERNRDGQRGRR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCD_PROM5
Sequence: MSLIDWFAARRKDQFVGKVSQDTEESDGLWVKCSECGQVAYRKDLISNFNVCSNCSHHNRINSDERINIIADKDSFKEFDDSLSPTDPLKFKDRRSYSDRIKESQEGTGLKDGVITGICSINSMPLALAVMDFRFMGGSMGSVVGEKITRIIEKATIENYPIVIVCASGGARMQEGMLSLMQMAKISGALKKHRAKNLLYMPLLTHPTTGGVTASFAMLGDLILAEPKALIGFAGRRVIEQTLREKLPDNFQTAEYLLEHGFVDVIVNRKELKSTLTSILKIHGVKDLMGAN
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUP6_MOUSE
Sequence: MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE
What is the function of this protein?
Binds pheromones that are released from drying urine of males.  These pheromones affect the sexual behavior of females.
What are the official names of this protein?
Major urinary protein 6, MUP 6, Alpha-2U-globulin, Group 1, BS6.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RFU1_CANGA
Sequence: MKSTQQLGQEAREFEFNPNIPLHLYLKTCVTLLNNASECFQRGDKSLSYFYYFRYVDLCTNKLPNHPTIRSTSTGLDNDSKLYVQEYKQLLRLEVPHILKIMEELKTELDAMYERHKVSLANNIASPISYKHNNRMDALLHDYYTERGCTGHSMQHKTSLHKNENFNERINLMKDSFMGRAPNGSQEVRNVSNTFYPDLPTLS
What is the function of this protein?
Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.
What are the official names of this protein?
Regulator of free ubiquitin chains 1.
What is the protein family that this protein belongs to?
Belongs to the RFU1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: OPTN_MACMU
Sequence: MSHQPLSCLTEKGDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVTRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSIGTSRSAEGAKNYLEHEELTVSQLLLCLREGNQKVERLEIALKEAKERVSDFEKKASNRSEIETQTEGSTEKENEEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLAMLQLTHNKLLQEHNHALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDPDQQAYLVQRGTEDRDWQQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
What is the function of this protein?
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8.  Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation.  Negatively regulates the induction of IFNB in response to RNA virus infection.  Plays a neuroprotective role in the eye and optic nerve.  Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death.  May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD).  Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment.  Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
What are the official names of this protein?
Optineurin.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans- Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy.