PharMolix/UniProtQA huggingface dataset:
Protein: DPOL_CEV01
Sequence: MSQWQFKLFEFDIREELETDKNEFIPGRDTKRFIIQMYGIDENGKTACIFVKGFNPFFYVKVLDEWDNSKVTEFVAFVRKEMGAYFGDSLVSAKIVYRHKFYEFDNKKLYKFVQLKFTSIGAFNKCKNLWYNETKYGEDRKLKENGLEFLDTKTTLYEAQVPPLLRLFHIRQIKPSGWVALKNGHYSQNRKQLTTCDYEFTVNYKNIYPINDERLEKICVPFKILSLDIEASSSHGDFPLARKNYLKLATNIVDYLINNNIETCDKDLLSNLIKTGFSYRINKDIEKIYLKKSITEEELDELIDNLVDIKPGKKENYIDIKDEDENSDSSDIENDGIVEEFTTKKRQKVTGTKNKDSNILEIINDLTCNRNTRILELAKCFGQHNPNRDNKWEGKFPELEGDQVTIIGSTIRRNGEDKPYLQHAIVVNDCNSIDNVVIESYKTERDALLAWTNFVQRENPDIIIGYNHHGWDEGFMYDRSIELNCMTQFSKLSRFKNEKCIKEIFQGKNKPKKITIEESSTKLASGQFDLRYFKMSGRLQIDFLNLFRREEQLPSYKLDYVAGHFIGDNIKKIEYDENCSILYSKNLTGLSKNDYIVIQEIGYSTDQYANGKKFKVLDIVDDKIILNDKITPDTNKILRWCLGKDDVGPQDIFRLTNEGPEGRAIVTKYCIKDCDLVQDLMRKNDTMTSYDEMSNLCWVPKSFLVTRGQGIKLTSYVAQKCREKNTLMPVIDKGIDGEGYEGAIVLEPKCNLYLKKPVACVDYSSLYPSSIISENISHDSKVWTKEYDLDDNLINETGEKDENGKFIYDELPEYDYIDITYDTFKWIRKTPKAAATKVKSGYKTCRYVQFQNNEKAILPSILDELLGARKSTKRQMKNETDPFMQNVLDKRQLSIKITANSLYGQAGAKTSTFYDKDIAASTTATGRKLLIYAKELIEACYDNTIEETTNYGEVKCYGEYIYGDSVASYTPIYVRYNKSIIDICSVEELAEKYGNGWHLESPKEYCELNNIESWTENGWTECHRVIRHRLAPYKKMVRILTHTGLVDVTDDHSLVKNTGEEISPKDVSIGTKLLHCTMSENESNIESDISIDEARIMGFFFGDGSCGIYDCPSGHKASWALNNSNKELIEKYYNLCKSVYPEFEWKVYDTLNSSGVYKICFNKKSGSKSKIQFIEKYRSMLYNKKSKIIPSEIINGSIELRKSFWEGLYDADGDKDKNGYTRIDQKSQISAAYICWLANSIGYKTSLNIRDDKTDIYRITATKNKQRRDGDKIKKIVNIQNSANIQNSANIQNSVNIQNSVNIQNSKDNQDYVYDLTTENHHHFAAGIGNMIVHNTDSVFFTFNLKDLDSKEIVGKKALEITIELAKKAGWLATMFLKSPHDLEYEKTFLPFCLLSKKRYVGILYEEDPNKGKRKEMGLVLKRRDNCAQVKDVYGGAIDILMKDQVVHKAVDFVKHSLQDVIDEKISQQKLIITKSLRSYYKNPKQIAHNVLAIRIGERDPGNKPKPGDRMEFIYIKNSDKKALQGDRIETPLFINENNIEIDYGFYITNQIMKPLQQLFALVLEDMEDFVTKRGISMKSWKAEIDKLHEKWTEPDKFSKKYEELRCKEVKSILFDPYIKLLK
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: DCNL3_PONAB
Sequence: MGQCVTKCKNPSSTLGSKNGDRDPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT
What is the function of this protein?
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage.  At the cell membrane, can promote and as well inhibit cullins neddylation.
What are the official names of this protein?
DCN1-like protein 3, DCNL3, DCUN1 domain-containing protein 3, Defective in cullin neddylation protein 1-like protein 3.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=After UVC treatment, the protein enters to the nucleus gradually. Cell membrane localization is essential for CUL3 neddylation.
Protein: MHPD_ECOHS
Sequence: MTKHTLEQLAADLRRAAEQGEAIAPLRDLIGIDNAEAAYAIQHINVQYDVVQGRRVVGRKVGLTHPKVQQQLGVDQPDFGTLFADMCYGDNEIIPFSRVLQPRIEAEIALVLNRDLPATDITFDELYNAIEWVLPALEVVGSRIRDWSIQFVDTVADNASCGVYVIGGPAQRPAGLDLKNCAMKMTRNNEEVSSGRGSECLGHPLNAAVWLARKMASLGEPLRAGDIILTGALGPMVAVNAGDRFEAHIEGIGSVAATFSSAAPKGSLS
What is the function of this protein?
Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.
What are the official names of this protein?
2-keto-4-pentenoate hydratase, 2-hydroxypentadienoic acid hydratase.
What is the protein family that this protein belongs to?
Belongs to the hydratase/decarboxylase family. MhpD subfamily.
Protein: PYRD_BRUSU
Sequence: MSGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMAAGYDKNAEVPDALLKLGFGFAEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHEAAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFYQLARYFTVNISSPNTPGLRNLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGIIVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAETALAKIKAGADLVQLYTGLIYRGPGLPGEILRGLSTAIKHEGVSSIAELRDRDTKEWAARKLIS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PEPT_SALCH
Sequence: MDKLLERFLHYVSLDTQSKSGVRQVPSTEGQWKLLRLLKQQLEEMGLVNITLSEKGTLMATLPANVEGDIPAIGFISHVDTSPDFSGKNVNPQIVENYRGGDIALGIGDEVLSPVMFPVLHQLLGQTLITTDGKTLLGADDKAGVAEIMTALAVLKGNPIPHGEIKVAFTPDEEVGKGAKHFDVEAFGAQWAYTVDGGGVGELEFENFNAASVNIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADEAPETTEGYEGFYHLASMKGTVDRAEMHYIIRDFDRKQFEARKRKMMEIAKKVGKGLHPDCYIELVIEDSYYNMREKVVEHPHILDIAQQAMRDCHITPEMKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAELTAKRGQ
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_STAA8
Sequence: MKLQTTYPSNNYPIYVEHGAIDHISTYIDQFDQSFILIDEHVNQYFADKFDDILSYENVHKVIIPAGEKTKTFEQYQETLEYILSHHVTRNTAIIAVGGGATGDFAGFIAATLLRGVHFIQVPTTILAHDSSVGGKVGINSKQGKNLIGAFYRPTAVIYDLVFLKTLPFEQILSGYAEVYKHALLNGESATQDIEQHFKDREILQSLNGMDKYIAKGIETKLDIVIADEKEQGVRKFLNLGHTFGHAVEYYHKIPHGHAVMVGIIYQFIVANALFDSKHDINHYIQYLIQLGYPLDMITDLDFETLYQYMLSDKKNDKQGVQMVLIRQFGDIVVQHVDQLTLQHACEQLKTYFK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ELAV1_MOUSE
Sequence: MSNGYEDHMAEDCRDDIGRTNLIVNYLPQNMTQEELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAISTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNMALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGISGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK
What is the function of this protein?
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability.  Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (PubMed:24394384).  Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (By similarity).  Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs.  Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs.  In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs.  Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity).  With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A.  Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity.  May also bind with ZNF385A the CCNB1 mRNA (PubMed:21402775).  Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:27616329).
What are the official names of this protein?
ELAV-like protein 1, Elav-like generic protein, Hu-antigen R, HuR, MelG.
What is the protein family that this protein belongs to?
Belongs to the RRM elav family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, Stress granule. Cytoplasm, P-body. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2. Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (By similarity). Localizes to the stress granules in the presence of PLEKHN1.
Protein: DPH22_CANAL
Sequence: MTSETVIAPSLSTAQNDGTFTYDKVKSTAKERKHLNLKNPSDANEIKSKIWNYYSLSELIQYLGQKENDDFKYKRITLQFPDNLICDSATIVHELQRELNIVPQANQDTGESNTAQRVWILADTSYSACCVDEVAAEHVRSDLVVHFGDACLNEIDKLQAVFVLGKPTLDVDAIVKQIKTAYSTEQKVVLMSDAPHTYLLPEIAKQLPDYDILIADLPKTSRAKIIGYTPPPTGHKKFNRVFNTDTVEFGKYELFHITSPESPRLLQLTTNFASVTTYDPISGTVSTGPFPNLMRRYKYVHQARMAGTVGILVNTLSLANTKVLLNTIKEKIKEAGKKHYIFVVGKPNVAKLANFESVDIWCILGCDHQGIIIDQINEYYKPIVTPYELLLGLSDELSWTGKWVVDYKSVLEEYGNEVIQQNEDPDTDEDLPPVFDPVTGRYVSTSKPLRQINHLMVTSSEQGGVDDHDNQLVKRFSNAVAIKGTVSTSAIHLQNRHWTGLGSDYTEDENAAGALVEDGRKGIARGYDI
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity).  Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2-2, Diphthamide biosynthesis protein 2-2.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASK_HORSE
Sequence: MKSFFLVVNILALTLPFLGAEVQNQEQPTCHKNDERFFDLKTVKYIPIYYVLNSSPRYEPIYYQHRLALLINNQHMPYQYYARPAAVRPHVQIPQWQVLPNIYPSTVVRHPCPHPSFIAIPPKKLQEITVIPKINTIATVEPTPIPTPEPTVNNAVIPDASSEFIIASTPETTTVPVTSPVVQKL
What is the function of this protein?
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
What are the official names of this protein?
Kappa-casein, Kappa-CN.
What is the protein family that this protein belongs to?
Belongs to the kappa-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS17_CERS4
Sequence: MPKRILQGTVTSDKNEQTVTVLVERRFKHPLLKKTVRLSKKYRAHDPENQFKVGDIVRIEECAPISKTKRWKVVTDAVVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: G3BP2_HUMAN
Sequence: MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGVDASGKPQEAVYGQNDIHHKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPERKFMQTFVLAPEGSVPNKFYVHNDMFRYEDEVFGDSEPELDEESEDEVEEEQEERQPSPEPVQENANSGYYEAHPVTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKNLEELEEKSTTPPPAEPVSLPQEPPKAFSWASVTSKNLPPSGTVSSSGIPPHVKAPVSQPRVEAKPEVQSQPPRVREQRPRERPGFPPRGPRPGRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELRINTKGVGGKLPNFGFVVFDDSEPVQRILIAKPIMFRGEVRLNVEEKKTRAARERETRGGGDDRRDIRRNDRGPGGPRGIVGGGMMRDRDGRGPPPRGGMAQKLGSGRGTGQMEGRFTGQRR
What is the function of this protein?
Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.
What are the official names of this protein?
Ras GTPase-activating protein-binding protein 2, G3BP-2, GAP SH3 domain-binding protein 2.
Protein: TRPA_ECO27
Sequence: MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEVLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAECEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKAFVQPMKAATRR
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: H2B_DROER
Sequence: MPPKTSGKAAKKAGKAQKNITKTDKKKKRKRKESYAIYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: VG12_ICHVA
Sequence: MTSPREEITVRLSCGHPLRVPDGEFCFGDGAYCCDCDERAVFFAPDHLTTVLSKVAPEGLDALTEKSWKLAKAIVTCGTCGDVLYQPVIHERCGHVCCRFCFRDKCAECGLMRTAVRPLPDLERLIQESLFGHDTRGLEYSDKFTAELMGPQGKEVILLYDGALGNVFVDLVTGISAVIADRAEKPIDLVDIVLNPDWSPVPCTIPYRLFRLLVKANAEMGVHDWSDLVTLGAWNILVEYGAVPGLDRSRLLEFLRYLVIPGFDGAETFPALTETFLSILAECTWVGDSRCGYRDACSR
What are the official names of this protein?
Putative zinc-binding protein ORF12.
Protein: MNMA2_CLOBL
Sequence: MSKGTVALAMSGGVDSSVSAYILKERGYDVIGIYMDLWRDEREEYCNKSAAEDARRVAEKLDIPFHVINIEKKFKNNVIDYFIDEYLSGRTPNPCVACNKTIKFEAFFNAAKEFGADFMATGHYCKIEERNGRKVIVKAEDDKKDQTYMMYNLKQYQLERTIMPCGEYKKDHIREIAESIGLDVYNKKDSQEICFIPDNDHGGFIKRNYKRKISEGNFVDKEGNIIGKHKGIIYYTIGQRKGLGIALGKPAYVIDINPITNEVVIGEEEDIFRTELIAKDVNFIPFDKLEKPMELEAKVRYSAKPSKATIIPLENNKVKVVFQNKQRAITKGQSVVFYDKDILAGGGIIEGIV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA 2.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NM111_CANGA
Sequence: MTIMNEGKKRSHSSSSDDHLAKRQYVEHGNECIMADEDIDTAIFEDGIKNNMQWQDTISKVVKAVVSIHFAQVAPFDCDPALVSEATGFVVDSELGIILTNRHVVGAGPFVGYVVFDNHEECDVIPIYRDPVHDFGFLKFDPKKIKYTKIHALELKPSLAKVGSEIRVVGNDAGEKLSILAGFISRIDRNAPDYGELTYNDFNTEYIQAAASASGGSSGSPVVNVDGYAVALQAGGSTEASTDFFLPLDRILRALKCIQADQPITRGTIQTQWLLKPYDECKRLGLTPEHESTSRALFPDRIGLLVAETILREGPSDGKIKEGDILIAINGQRISTFIQVDDILDSNVGNNVEFTVQRGGTDINVTCTIGDLHAITPSKYVEVCGATFNELSYQMARFYALPIRGVFLSSASGSFNFDNKEKIGWIVDSVNYQDTPNLDAFVEVMKTIPDKSRVTVRYHHLTDQHSPNVTSIYIDRHWCSEFRIYERNDKTGIWDYTNVADPISEEPLKPHTAKFIPIPSTNPEIAKLSSSLCMVHTVAAIPIDSLSAETLKTSGLIIDAEQGYVIVSRRAVPHDCLDVFVTIADSIVIPATIEFLHPMQNYAIVKYDPNLVKAPVVTPKLSNRRMKRGESAQFIGYTHNNRLITSETSVTDISSVSIPSNLIPRYRATNLEAISIDSNISPRCNFGIMTDQDGTVRALWLSFLGERQENKEKVYLMGLDIMDCKNVINILKSGKKPQVHIIDAGFGSISILHARIRGVPEEWIQKMEAESNNRLQFITVSRVSYTEETVKLQTGDVILSVNDKLVTEMDQLSGIVHASDENIDSHVLHFKVVRDGKIVDLDMKTVQVDETDQIVIFAGCILQKPHHAVRQAMSDIPKGVYCTFRGESSPAIQYGISATNFITHVNEIPTPDLDKFLEVVRQIPDNTYCKIRMMTFDNVPFAISLKTNYHYFPTAELKKNKDTGKWIEKEYNNSQEIPK
What is the function of this protein?
Nuclear serine protease which mediates apoptosis.
What are the official names of this protein?
Pro-apoptotic serine protease NMA111.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEBP2_MOUSE
Sequence: MAEEPEPDLGVAEGSEDQALEMPSWKAPEDIDPQPGSYEIRHYGPAKWVSTCVESLDWDSAIQTGFTKLNGYIQGKNEKEMKIKLTAPVTSYVEPGSSPFSESTITISLYIPSEQQPDPPRPSESDVFIEDRAEMTVFVRSFDGFSSGQKNQEQLLTLANILREEGKVFNEKVFYTAGYSSPFQLLDRNNEVWLIQKNEPSVENK
What is the function of this protein?
Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions (By similarity).  May have low affinity for heme (PubMed:15518569).
What are the official names of this protein?
Heme-binding protein 2, Protein SOUL.
What is the protein family that this protein belongs to?
Belongs to the HEBP family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion.
Protein: Y2027_ARATH
Sequence: MLFKMRSFVAFVLLLSWFGSCCSLKDQAVDFLKSEDSLKKDLSSDEDSTYLKAFGFHRKTLVRNPYKDLPSRKDRKNRVVAATTTPSSSPEPAPKHVSTKASTVSEPQKRSSTQDVSPSPSAPLANSPIPRNSHSSVPLVVGCVGGAFFLLLVATGLYFFTSKAGKTVNPWRTGLSGQLQKVFVTGIPVLKRSEIEAACEDFSNVIGSCPIGKLFKGTLSSGVEIAVASFATTTAKDWKDSTEIHFRKKIEMLSKINHKNFANLLGYCEEKEPFTRILIFEYAPNGSLFEHLHYKESEHLDWGMRLRIAMGLAYCLDHMHQLNPPIAHTNLVSSSLQLTEDYAVKVSDFSFGSSETETNINNNTVIDTHISALNPEDNIYSFGLLLFEMITGKLIESVNKPDSVDSSLVDFLRGETLAKMVDPTLESYDAKIENIGEVIKSCLRTDPKERPTMQEVTGWLREITGLSPNDATPKLSPLWWAELEVLSTA
What are the official names of this protein?
Inactive receptor-like serine/threonine-protein kinase At2g40270.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: TOMT_MOUSE
Sequence: MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRGFRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSCCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG
What is the function of this protein?
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (PubMed:18794526).  Required for auditory function (PubMed:18794526, PubMed:28504928).  Component of the cochlear hair cell's mechanotransduction (MET) machinery.  Involved in the assembly of the asymmetric tip-link MET complex.  Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells.  The function in MET is independent of the enzymatic activity (PubMed:28504928).
What are the official names of this protein?
Transmembrane O-methyltransferase homolog, mTOMT, Catechol O-methyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Note=Localized to the cell body of the cochlear hair cells, but is not present in the stereocilia. Present but not restricted to the apical cistern, Hensen's body and the subsurface cistern.
Protein: BIOD_METNO
Sequence: MSTLFVAGAGTEIGKTYVTAALTRALRASGRPVRALKPVASGVPDLSDPDFSASDTALLLAAQDLPVTPETVAAMTPWRFAAPLAPDLAAAREGRSLALADLVAWCETAIAAPAPGTAVLIEGVGGLMSPLTAEATGLAWLKALRLPVLLVSGSYLGAISHALTAIETLHHHAVDLRAVVVSETPGAPTPPETVAEAIARHAGVRVLCVARGGGFPAEGLDVVPA
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_ECO7I
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRNHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVISHRVETGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIDGQSKPLLIYGKPEAQQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: HIS7_CHLT3
Sequence: MPKRRARVTRKTKETDIAIELVLDGNGKYEIQSGIRFLDHMLESFSKHSRIDIALTCTGDVDVDDHHSIEDIAIVLGSAISQALGDKRGIQRYGWAIIPMDESLARAAIDLSGRSYLFFDAVFDRPTVSDLSTEMVEHFFFSLAEHLKANIHLEILHGKNTHHKVEALFKSLAVAMREAVKITSNEVLSTKGVI
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_SINFN
Sequence: MHNYLDFEKPISDLEGKILELKKLAGEDESVNTSDEVARLEGRVRDAMMEIYSKLSPWQKTQVARHPSRPHFLDYAAELFTEFTPLAGDRNFANDDAIQAGLARFRGAPVAVIGQEKGNDTKSRIKHNFGSPRPEGYRKAVRVMEMADRFGLPLITLVDTAGAYPGVNAEERGQAEAIARSTEMCLNVKVPIVTVVIGEGGSGGAIAIATGNRVYMLEHSIYSVISPEGAASILWRDSTRAKEAASNMKITAEDLKSLGVIDGIIPEPVGGAHRDPQAVIGRTGTVIADALKELSGRNGDELRADRRQKYLNIGRNL
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_CALS4
Sequence: MIQKIIFATLLSFTVAIISGRFFIPYLRKLKFGQKVREDGPKTHLKKSGTPTMGGIIFVVATFLTSLIFSPWNKYLFILLAGFLGYGLIGFADDFLKVYFKRSLGLRAREKLLAQFLLAIVISWFIKSNVGTEIIVPFFKRSVDLANFYIPFAVFIIVGTVNSVNLTDGLDGLAAGVSTIVMAFFAMIALFLNDVTYGVFSASLTGGLLGFLRYNKHPAEVFMGDTGSLAIGGAVATVALLTKLPLILPVLGIIYVAEAISVILQVFSFKLFGKRIFKMSPLHHHFELSGWKEEKVVYSFWLVTLIALFVSFYSLS
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATP6_ENT38
Sequence: MASENMTPQDYIGHHLTNLQMDLRTFSLVDPHNPPATFWTLNIDSMFFSVVLGLLFLAMFRSVAKKATSGVPGKFQTAIELVIGFVHGSVKDMYHGKSKLIAPLALTVFVWVFLMNLMDLLPIDLLPYIGEHVFGLPALRVVPSADVNITLSMALGVFILILFYSIKMKGVSGFVKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.