PharMolix/UniProtQA huggingface dataset:
Protein: DHE2_YEAST
Sequence: MLFDNKNRGALNSLNTPDIASLSISSMSDYHVFDFPGKDLQREEVIDLLDQQGFIPDDLIEQEVDWFYNSLGIDDLFFSRESPQLISNIIHSLYASKLDFFAKSKFNGIQPRLFSIKNKIITNDNHAIFMESNTGVSISDSQQKNFKFASDAVGNDTLEHGKDTIKKNRIEMDDSCPPYELDSEIDDLFLDNKSQKNCRLVSFWAPESELKLTFVYESVYPNDDPAGVDISSQDLLKGDIESISDKTMYKVSSNENKKLYGLLLKLVKEREGPVIKTTRSVENKDEIRLLVAYKRFTTKRYYSALNSLFHYYKLKPSKFYLESFNVKDDDIIIFSVYLNENQQLEDVLLHDVEAALKQVEREASLLYAIPNNSFHEVYQRRQFSPKEAIYAHIGAIFINHFVNRLGSDYQNLLSQITIKRNDTTLLEIVENLKRKLRNETLTQQTIINIMSKHYTIISKLYKNFAQIHYYHNSTKDMEKTLSFQRLEKVEPFKNDQEFEAYLNKFIPNDSPDLLILKTLNIFNKSILKTNFFITRKVAISFRLDPSLVMTKFEYPETPYGIFFVVGNTFKGFHIRFRDIARGGIRIVCSRNQDIYDLNSKNVIDENYQLASTQQRKNKDIPEGGSKGVILLNPGLVEHDQTFVAFSQYVDAMIDILINDPLKENYVNLLPKEEILFFGPDEGTAGFVDWATNHARVRNCPWWKSFLTGKSPSLGGIPHDEYGMTSLGVRAYVNKIYETLNLTNSTVYKFQTGGPDGDLGSNEILLSSPNECYLAILDGSGVLCDPKGLDKDELCRLAHERKMISDFDTSKLSNNGFFVSVDAMDIMLPNGTIVANGTTFRNTFHTQIFKFVDHVDIFVPCGGRPNSITLNNLHYFVDEKTGKCKIPYIVEGANLFITQPAKNALEEHGCILFKDASANKGGVTSSSMEVLASLALNDNDFVHKFIGDVSGERSALYKSYVVEVQSRIQKNAELEFGQLWNLNQLNGTHISEISNQLSFTINKLNDDLVASQELWLNDLKLRNYLLLDKIIPKILIDVAGPQSVLENIPESYLKVLLSSYLSSTFVYQNGIDVNIGKFLEFIGGLKREAEASA
What is the function of this protein?
NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.
What are the official names of this protein?
NAD-specific glutamate dehydrogenase, NAD-GDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: AROQ_CAMJD
Sequence: MKIMIIQGPNVNMLGVREVGIYGAMKMEEIHEQMKLAASQNNVELDFFQSNFEGEIVDKIQECLGTVDGIIINAAGYTHTSVAIRDAIAAVALPTIEVHISNVYRREEFRQKNLIAPVCSGTIVGFGPFGYHLALMGIIQICEQIKNLRAMQQAQQTNK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: YPU2_RHOCA
Sequence: MNNPWLVALTTIFVWWFSTGAILWRIRRADLSGRAAHMRSVVGGLPLLIGGYIAMANSADDSSVRGAHVAFLSAVSVWGWFELAFLSGVVAGPNRDHCPPFASMTERFLRSVGTLLWHEIGLISALILCAVLVWTGENHFGLWTFATLFFARVSAKLNLFLGVPRINTQFLPKPLAHLASHFRHARMNFLFPVSITVLTFATGCWMERAADAQTDGIFIGFVLLTVLTALALLEHWFMVLPLPDQKLWTWMLPSVEDPAETVAEPVPGRIPVGE
What are the official names of this protein?
Uncharacterized 30.4 kDa protein in puhA 5'region, ORF274.
Protein: SODC_MYCLE
Sequence: MSKLAGHRNVAAVTRSALSLSFVAACVALLSACIQNQPPATLPGTTPTVWTGSPAPSGMLGAEAESMGPPNIITRLNAPDGTQVATAKFEFNNGFATITIATTGVGHLAPGFHGVHIHKVGKCEPSSAGPTGGAPGDFLSAGGHFQVPGHTVEPASGNLTSLQVRKDGIGTLVTTTDAFTMNDLLAGQKTAIIIHAGADNFGNIPPERYSQVNGTPGPDATTISTGDAGKRVACGVIGAD
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.  May play a role in favoring mycobacterial survival in phagocytes (By similarity).
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: KTHY_ECO57
Sequence: MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVGDEIITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQDKSIHTIDATQPLEAVMDAIRTTVTRWVKELDA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: WHIA_STAAS
Sequence: MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: RAPA_SHEPA
Sequence: MPFSLGQRWISDTESELGLGTVVGVEGRMVTVLFPATGENRLFSRTEAPLTRVIYNPGDTVESHEEWKLTVTEVEEKDSLIIYHGTHSETGEQVSLRETLLNHNIRFNKPQDRLFAGQIDRLDRFNVRYQCQLLRNKLATSDLLGLQGPRVGLIPHQQWIAHEVGQRFAPRVLLADEVGLGKTIEAGLIIHQQLLTGRAERILVIVPDTLRHQWLVEMLRRFNLRFSVFDEDRCVEAYADHDNPFYTEQLVICSLDLLRKKRRLDQALDADWDLMVVDEAHHLEWSEEAPSRAYQIVEALSEEIPGVLLLTATPDQLGHQSHFARLRLLDPDRFYDYEAFLKEEDSYKDVATAADALASGEILSDESIAGLTQLLAEKDISASITLIQDDAADADSRFQARDELLQDLLDRHGTGRVLYRNSRASVKGFPVRNLHVHPQKMPEQYVTAYRVSSMMNKHLDTNAKVRQVLSPEKIYQDFDSGSAAWWKFDPRVDWLIDFLKNNRSKKVLIIASQAETALSLEEALRTREGIQATVFHEGMSIIERDKAGAYFAQESGGAQALICSEIGSEGRNFQFASNLVLFDLPLNPDLLEQRIGRLDRIGQKNDVEIHLPFLANTAQERLMQWYHQGLNAFECTCPSGHILFNEFSGELLESLLNNDEAVLESLLDGTKARYQELKVAMEQGRDKLLEINSHGGERANQLVKTLADKDEDTQLIGSVIRLWDIIGVEQEDSGENAIVLHPSEHMMFPTYPGLPEDGITVTFDREMALSRDDIALITQEHPLVQTGLDLITSSETGTTSVAVLKNKALPAGTIFLELIYLADASAPKSSQLYRYLPPTPIRVLLDKNGNNLSDNVTYESFNKQLSAVNRHIASKLVNASQAILHPLFAKAESFATTQLETLTECAREKMTSQLSGELERLKALKAVNPNIRDEELSHLSEQMAELNRYLDSSQLQLDAIRLVLVSHA
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: MUKB_SALTY
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLSLAELKDKLDEMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRLTLEAIRVTQSDRDLFKHLISEATDYVAADYMRHANERRVHLDQALAFRRDLYTSRKQLAAEQYKHVDMARELGEHNGAEGSLEADYQAASDHLNLVQTALRQQEKIERYEADLEELQIRLEEQNEVVAEAAEMQDENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAISALARAKELCHLPDLTPESAAEWLDTFQAKEQEATEKLLSLEQKMSVAQTAHSQFEQAYQLVAAINGPLARSEAWDVARELLRDGVNQRHLAEQVQPLRMRLSELEQRLREQQEAERLLAEFCKRQGKNFDIDELEALHQELEARIASLSESVSSASEQRMALRQEQEQLQSRIQHLMQRAPVWLAAQNSLNQLSEQCGEEFTSSQEVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGAEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQIAEQLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPSLPIFGRAARENRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLSVAFEDDPEAEIRRLNGRRVELERALATHESDNQQQRLQFEQAKEGVSALNRLLPRLNLLADETLADRVDEIQERLDEAQEAARFVQQYGNQLAKLEPVVSVLQSDPEQFEQLKEDYAWSQQMQRDARQQAFALAEVVERRAHFSYSDSAEMLSGNSDLNEKLRQRLEQAEAERTRAREALRSHAAQLSQYSQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARQRRDELHAQLSNNRSRRNQLEKALTFCEAEMENLTRKLRKLERDYHEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADELRSMSDKALGALRLAVADNEHLRDVLRLSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQSVSFGQVNSVRLNVNVRETHATLLDVLSEQQEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDEARRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGTQTEDTPSEAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: CLPP2_MYCBO
Sequence: MNSQNSQIQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLSGVIQGQFSDLEIQAAEIERMRTLMETTLARHTGKDAGVIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_ARCFU
Sequence: MGDPKRHRKKYTTPTHPWDKARLEKEMQLVIKYGLRNKRELWRFQNILRKYRRVARDLLAEIGLPGKEGEIAKAKAQTVIKKLNKMGILPENATLDDILNLSVEDFLERRLQTMVYRQGLARTIKQARQFITHGHIAVDGRRVTSPSFIVTKELESKISFYRNSPLAKTEVV
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: NDUV3_HUMAN
Sequence: MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKKPAPVPAEPFDNTTYKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.  May be the terminally assembled subunit of Complex I.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial, Complex I-9kD, CI-9kD, NADH-ubiquinone oxidoreductase 9 kDa subunit, Renal carcinoma antigen NY-REN-4.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFV3 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: NHR4_CAEEL
Sequence: MNERGMLVDPRFDAFFKLEQIDDYKYDGADTSPSTSNGLPETSNGGRLICDVCGDVAFGKHYGINACNGCKGFFRRSVWSRRQYSCRFGGDCPVVKEHRNVCRSCRLKKCFEVGMNPDSVQNERDRNAKNGGMGGPMSSPTQSSLCKELTISNGQIKRKRLRPETVEKTTQTDGKLEINDDFDFENMQQNPTPPGLLPLKIERISTPPSDLPVPMDFSIHSAVLDIEQKVFYNCPVAVDNSINATKTPITLPFEVVFRQPHLVCNRYPMRFSNTRVLTPEDLIDGWRRHFTYYSDWCHAMDEFKALSPEDQIVLAKKKIILHGWLVHAYYSYKSGCNGICFANGAAHLPEGGHPSITEFYKECMPRYLNYVIYPMHNFQMDDAEMVLIKCIMFFSSESGLSAAGRQIVSAAREKYLSALYNYGRANKCTTSAQATLRIAKFMIMLSAITSLTHLMNEGVHVTSLFNIIEFDELIQATHKTTPPQHSPPAPMG
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-4.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCP60_HUMAN
Sequence: MAAVLNAERLEVSVDGLTLSPDPEERPGAEGAPLLPPPLPPPSPPGSGRGPGASGEQPEPGEAAAGGAAEEARRLEQRWGFGLEELYGLALRFFKEKDGKAFHPTYEEKLKLVALHKQVLMGPYNPDTCPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGEVVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEENIGCEEKAKKNANKPLLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR
What is the function of this protein?
(Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites.
What are the official names of this protein?
Golgi resident protein GCP60, Acyl-CoA-binding domain-containing protein 3, Golgi complex-associated protein 1, GOCAP1, Golgi phosphoprotein 1, GOLPH1, PBR- and PKA-associated protein 7, Peripheral benzodiazepine receptor-associated protein PAP7.
Protein: RHMD_ECOK1
Sequence: MENIMTLPKIKQVRAWFTGGAIAEKGAGGGDYHDQGANHWIDDHIATPMSKYRDYEQSRQSFGINVLGTLVVEVEAENGQTGFAVSTAGEMGCFIVEKHLNRFIEGKCVSDIKLIHDQMLNATLYYSGSGGLVMNTISCVDLALWDLFGKVVGLPVYKLLGGAVRDEIQFYATGARPDLAKEMGFIGGKMPTHWGPHDGDAGIRKDAAMVADMREKCGEDFWLMLDCWMSQDVNYATKLAHACAPYNLKWIEECLPPQQYEGYRELKHNAPAGMMVTSGEHHGTLQSFRTLSETGIDIMQPDVGWCGGLTTLVEIAAIAKSRGQLVVPHGSSVYSHHAVITFTNTPFSEFLMTSPDCSTMRPQFDPILLNEPVPVNGRIHKSVLDKPGFGVELNRDCNLKRPYSH
What is the function of this protein?
Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).
What are the official names of this protein?
L-rhamnonate dehydratase, RhamD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
Protein: FOLD_NATPD
Sequence: MTEVIDGNAVASDIRDDLTDAIATLADAGARPGLATVLMGDDPASETYVNMKQRDCEEVGIESYHVDVDGDAPPETLYDEIAALNQNDDVHGYIVQAPVPDHVDYREVIRRVDPQKDVDGFHPENVGRLVAGDARFRPCTPHGVQKLLEAADIDTEGKDVTIVGRSDIVGKPLANLLIQKADDGNATVTVCHSRTENLAAKTRRADIVVAAAGAPELVDGSMIGEGSVVIDVGVNRVDADNEKGYELVGDVEYESATQNASAITPVPGGVGPMTRAMLLYNTVKAASLQEDIDVALP
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RECA_STRGC
Sequence: MAKKQKNLDDITKKFGDERQKALDNALKNIEKDFGKGAIMRLGERAEQKVQVMSSGSLALDIALGAGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAAFIDAEHALDPSYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVIDSVAALVPRAEIDGDIGDSHVGLQARMMSQAMRKLSASINKTKTIAIFINQLREKVGVMFGNPETTPGGRALKFYASVRLDVRGNTQIKGTGDAKDTNVGKETKIKVVKNKVAPPFKEAFVEIMYGEGISKTGELIKIATDLNIIKKAGAWYSYNDEKIGQGSENAKKYLADHPEVFDEIDRQVRVRFGLIEDDQEGEATAAETTGKITENIEEVTLELDDAIEIEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WCAB_SHIFL
Sequence: MLEDLRANSWSLRPCCMVLAYRVAHFCSVWRKKNVLNNLWAAPLLVLYRIITECFFGYEIQAAATIGRRFTIHHGYAVVINKNVVAGDDFTIRHGVTIGNRGADNMACPHIGNGVELGANVIILGDITLGNNVTVGAGSVVLDSVPDNALVVGEKARVKVIK
What are the official names of this protein?
Putative colanic acid biosynthesis acetyltransferase WcaB.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: RN2A_LITCL
Sequence: GLFLDTLKGAAKDVAGKLLEGLKCKIAGCKP
What is the function of this protein?
Antibacterial activity against Gram-positive bacterium S. aureus and Gram-negative bacterium E. coli.  Has activity against C. albicans.
What are the official names of this protein?
Ranatuerin-2Ca.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Ranatuerin subfamily.
Protein: 1A1D_BURO1
Sequence: MNLQRFPRYPLTFGPTPIQPLKRLSAHLGGKVDLYAKREDCNSGLAFGGNKTRKLEYLVPDALAQGADTLVSIGGVQSNQTRQVAAVAAHLGMKCVLVQEHWVNYEDPVYDRVGNIQLSRMMGADVRLVSDGFDIGIRRSWEEAMESVRQAGGKPYPIPAGCSEHPLGGLGFVGFAEEVRAQEAQLGFKFDYVVVCSVTGSTQAGMVVGFAADGRADRVIGIDASAKPEQTREQITRIARHTAELVELGRDIVEQDVVLDTRYGGPEYGLPSDGTLEAIRLCARLEGMLTDPVYEGKSMHGMIDKVRLGEFEPGSKVLYAHLGGAPALSAYNGIFRNG
What is the function of this protein?
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate.  Allows growth on ACC as a nitrogen source.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate deaminase, ACC deaminase, ACCD.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: HBA1_IGUIG
Sequence: VLTEDDKNHIRAIWGHVDNNPEAFGVEALTRLFLAYPATKTYFAHFDLNPGSAQIKAHGKKVVDALTQAVNNLDDIPDALAKLADLHAEKLRVDPVNFGLLGHCILVTIAAHNHGPLKADVALSMDKFLTKVAKTLVAHYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1, Alpha-1-globin, Hemoglobin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: MQO_ACIBC
Sequence: MKKFLKYLLVLIILILIAGIVFLFRPIASKQVQTAKDEPVVDAVLVGGGIMSATLGTYFTELEPNWQIRMFERLDQVAQESSNGFNNAGTGHSGFMEMNYTEEKNGKMEIAKAEKVASQFEVAKQFWSYQVKQGVLAEPKTFINPVPHIAFVWGDNVKFLEKRYAAMIQSPLFKGMKFTEDPAVIKQWAPLVMTDRDPTQKVAATRMEVGSDVNYGSITKQLVNHLNQNPNFKLQTSTEVTGISQNDDKTWTVSFKNLKTGKTDHVKTRFVFIGAGGAAVKLLQLTGLPEAKQYAGFPVGGEFLITDNPAITAQHTAKVYGRAELGAPPMSVPHIDTRYIDGKKYVLFGPFATYSNKFLKNGSQLDLLASTNKSNVLPMTTVGLENLDLVKYLVSQVMMSDEDRLNELRKYYPDAKAEDWRLSQGGQRVQIIKKEPGKPATLQFGTEIFASKDGAVTALLGASPGASTSPYIMLNLLEKAFPQQTEGKWNQKLHEIVVSYKQDLSKDPVLLDKVRQYTSSTLGLNYTSPFKAANDETAAAPVAKAN
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: PHNG_PENHR
Sequence: MAAETATSKQNLVILGGSYAGLSTAHYLLRHVVPQLPGKESYQVILISASSEAMCRPACPRALISDDMFQQDKLFVSIPAQFEQYLKDTFKFIHGTVTSLDHQDRCVTVSVKDGDPEKIKCHAIVIATGASTASPLLGLNRDSETLRTNWNEFRAALPTAKHIVIAGGGPAGVETAGELGEYLNGRAGWFHSKLENPKVEITLVTADSKILPILRPALATKAEKLLNKVGVTVIKKSRVTNVTPPGAGAEDALTANATVTLEDGKELQADLYIPATGMTYNSSFVDASLLTDYGRVETDPGTLRVVNGGALLYAIGDVGSHARPAVHNILNTVPILCANMKRDLLLAVQPDASVGEDRQFKEDTRETQLVPVGRSKGVGAFMGFRQPGFMVWLIKGRDYWLWTTEGLWSGKHWAKGS
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of phenalenones such as herqueinone, compounds that have been reported to treat tumors, bacterial infections and/or mycoses, and rheumatic diseases (PubMed:26978228).  The non-reducing polyketide synthase phnA synthesizes the heptaketide backbone and cyclizes it into the angular, hemiketal-containing naphtho-gamma-pyrone prephenalenone.  The product template (PT) domain of phnA catalyzes only the C4-C9 aldol condensation, which is unprecedented among known PT domains (PubMed:28240554, PubMed:26978228).  The transformation of prephenalenone to phenalenones requires an FAD-dependent monooxygenase phnB, which catalyzes the C2 aromatic hydroxylation of prephenalenone and ring opening of the gamma-pyrone ring simultaneously (PubMed:28240554, PubMed:26978228).  Subsequent intramolecular deprotonation of C3 phenolic oxygen accelerates phenalenone ring closure to yield the tricyclic phenalenone core with a C2 hydroxylation (PubMed:28240554, PubMed:26978228).  The prenyltransferase phnF further catalyzes reverse C-prenylation of phenalenone by direct electrophilic substitution at C6, or possibly via first a forward O-prenylation of a neighboring phenol in phenalenone, followed by a Claisen rearrangement (PubMed:28240554).  The hydroalkoxylation enzyme phnH catalyzes the 5-exo-trigcyclization via acid catalysis after the spontaneous deprotonation of 7-OH, which leads to the formation of the dihydrobenzofuran atrovenetin (PubMed:28240554).  Atrovenetin is further converted to deoxyherqueinone by the O-methyltransferase phnC which can methylate C2-OH to stabilize the northern portion of the phenalenone core (PubMed:28240554).  Finally, the oxidoreductase phnG converts deoxyherqueinone to herqueinone via C6 hydroxylation (PubMed:28240554).
What are the official names of this protein?
Oxidoreductase phnG, Phenalenone biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
Protein: PFDB_PYRAE
Sequence: MAQIPPSLQDLVNRFNQAQAQLQNVLLRKQQYEAELKEVEKAISEIERLPQDAKIFKNVGNFLVPQSRDVALQELRDRKELLELHVKTLTRQESMLREQLDKLREEINKELAKLKGGATEAAKGGG
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_XYLFM
Sequence: MASDFLPVHRALLSVSDKTGLVELARVLLAYNIELLSTGGTATIIREAGLPVQDVADLTGFPEMMDGRVKTLHPVVHGGLLGRAGIDDAVMAKHGIAPIDLLILNLYPFEQITAKKDCTLADAVDTIDIGGPAMLRSAAKNFARVAVATSPDQYPDLLAELQEHHGQLSAEKRFALAVAAFNHVAQYDAAISNYLSSVSDMHTTLPLRHEFPAQLNNTFVKMTELRYGENPHQTGAFYRDVHPQPGTLATFQQLQGKRLSYNNLVDADAAWECVRQFEAPACVIVKHANPCGVAVGMACSDAYEAAYATDPTSAFGGIIAFNRTLDAVTMKSILDRQFVEVFIAPYYDADALAYAAKKANVRVLRIPSSAAMKATNQYDFKRIGSGLLVQSADTMHIHSDVLRTVTTLAPTDKQRRDLMFAWRVVKYVKSNAIVYAKDNRTIGIGAGQMSRVYSARIAGIKAADAHLAVTGSVMASDAFFPFRDGIDAAAATGIKAVIQPGGSMRDNEVIAAADEHGIAMLFTGIRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: ORN_HYDCU
Sequence: MKSENNLIWIDLEMTGLDHKADQIIEIATVVTDAELNVLAEGPVMAIQTEQHYLDGMDAWCTTHHGNSGLTKRVQESTITMAQAEQETIKFLKPYVPKGKSPMCGNSICQDRRFLIEQMPELEQFFHYRNLDVSSLKELARRWAPTVYSGYKKKGAHLALDDIYESIEELKYYRQNLFLPEFQQ
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL10_BOVIN
Sequence: MHSSALLCCLVFLAGVAASRDASTLSDSSCIHLPTSLPHMLRELRAAFGKVKTFFQMKDQLHSLLLTQSLLDDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEKVKRVFSELQERGVYKAMSEFDIFINYIETYMTTKMQK
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.