PharMolix/UniProtQA huggingface dataset:
Protein: FEM1A_HUMAN
Sequence: MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398168, PubMed:33398170).  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398168, PubMed:33398170).  The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (PubMed:33398168, PubMed:33398170).  Promotes ubiquitination and degradation of SLBP (PubMed:28118078).  Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity).  Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity).
What are the official names of this protein?
Protein fem-1 homolog A, FEM1a, FEM1-alpha, Prostaglandin E receptor 4-associated protein.
What is the protein family that this protein belongs to?
Belongs to the fem-1 family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: SC4AA_DANRE
Sequence: MARLLPPTGTSVFRRFTPESLVEIERLIQEKSTREELEGAEEEPQAPSSDLEAGKCLPMIYGDPPGDLLNTPLEDIDPFYKTQKTFIVISKGNTIFRFSSEPAMFCISPFSIVRRGAIKILIHSLFSMFIMITILSNCVFMTMSNPPAWSKTVEYVFTGIYTFEATVKVLSRGFCIGPFTFLRDPWNWLDFMVISMAYVTEFVDLGNVSALRTFRVLRALKTITVIPGLKTIVGALIQSVKKMIDVMILTIFALAVFALIGLQLFMGNLRQKCIRWPILNSTIFDVYNSNMVNDTTLNVTDTFDFKAYINNEENQYFLEGSLDALLCGNSSDAGRCPEGYTCMKAGRNPNYGYTSYDNFGWAFLALFRLMTQDFWENLFQLTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYDEQNEATLAEARDKEEEFQRLLEQLKNQETGSKASLASQKTQSRGSNRTGSLHDLADEDVIKDCNGRIVPRLIVNRVSSNKELSAEEDQKSLSSKHSMQYLDQPKLSKRTASALSVLTATMEGLEDAQRPCPPGWYKFADMFLKWDCCAPWILFKKWVHFVVMDPFVDLGITICIVLNTLFMAMEHYPMSPHFEHVLSVGNLVFTGIFTAEMVFKLIAMDPYYYFQVGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKISEDCELPRWHMNDFFHSFLIVFRILCGEWIETMWDCMEVAGASMCLIVFMMVMVIGNLVVLNLFLALLLSSFSGDNLSGGDDDGEMNNLQIAIGRITRGIDWVKALVASMVQRILGKKPDNTKEEGEGDIELYALNHLDEGKMADGLTNCLSPTLTVPIARCESDVEEDEDSESSDEEDAKATLNDGDSSVCSTVDYQPPEPEPEPEEVEEEEPEPEEPEACFTEGCIRRCACLSVDITEGWGKKWWNLRRTCFTIVEHDYFETFIIFMILLSSGALAFEDINIERRRVIKTILEYADKVFTYIFIVEMLLKWVAYGFKTYFTNAWCWLDFLIVDVSLVSLTANLMGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTEERIPMDVVNNKSDCMALMYTNEVRWVNVKVNYDNVGLGYLSLLQIATFKGWMDIMYAAVDSREVDEQPSYEINLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKSKFGGKDIFMTEEQKKYYNAMKKLGAKKRPKPIPRPSNIIQGLVFDFISKQFFDIFIMVLICLNMVTMMIETDDQSAEKEYVLYQINLVFIVVFTSECVLKLFALRQYFFTIGWNVFDFVVVILSIAGLMLSDIIEKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKQAGIDDIFNFETFGGSIICLFEITTSAGWDGLLLPILNSGPPDCDPDFENPGTDVRGNCGNPGMGIMFFCSYIIMSFLVVVNMYIAIILENFNNAQEESGDPLCEDDFDMFDETWEKFDVDATQFIEYDRLFDFVDALQEPLRIAKPNRLKLISMDIPIVNGDKIHSQDILLAVTREVLGDTIEMDAMKESIEAKFIMNNPTSASFEPIITTLRRKEEERAAIAVQRIYRRHLLKRAIRYACFMRRSKRKVRNPNDNEPPETEGLIARKMNTLYGSNPELAMALELETRPMRPNSQPPKPSQVTQTRASVTFPRPQGQLILPVELTSEVILRSAPITHSLNSSENATTIKESIV
What is the function of this protein?
Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient.  Alternates between resting, activated and inactivated states.  Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles.
What are the official names of this protein?
Sodium channel protein type 4 subunit alpha A, Voltage-gated sodium channel subunit alpha Nav1.4a.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CCD14_MOUSE
Sequence: MSPGGPRPSSRKRKLRGRDKGGPDISAVNSFFLKYSFPYAWALLRLREMVRSGSRPGQVISSGRQPGAKLPNGKKGTHVRKIAHFNVDSACPVQSDSESQTDTLQGLDGCASLLRDILKNEDSGSEMVYSENRCNSKPLEGRKNRSKKKGPEKHVPSVVRKEILSSENRKWISNEASTGSDTAQRWSLQDHYRMYSPIIYQALCEHVQTQMSLMNSLALKNGPNGIHAVCHTMSNSGSQATPHSGFGCSPSASVWPPQQPSCPLMVHSEVQTDADNQFESQSQATSVKYGDVPRDPFSVHPGVACGLPHADSPAVAKSRQLDLTSCILPQQRAPKEAELLKCFQTHTSLFPAHGKDALSDSQAYQSPSQLQPAFLATNEEKCAKEQFEEATNEGKHLSTHVQDAKIAKNVQQAENVSQTAEKIRLAKCLLGELKALMEEDSEVQRLVTEVEACVSGLSAVSGHPNVEVEIALALQPLRSENAQLRRQLRILNQRLREQEKTEKGPGNLELFSLQSLNMSLQNQLQESLKSQELLQSKNEELLKVIENQKEENKKFTTLFKDKEQTLLHNKQQFDIEMTRVKMELEEALANEKNLRFKLETAEKESQILGITLRQRDAEVARLRELTRTLQSSMAKLLSDLSMDTARCRMGNSLTKSLLNVYDQQLQQDPAPAQTSIMSYLNKLETNHSFIHSKLLNNEAAIEPDRLCESVLPPQRPPHSDAGTADGGSASGTVSAASVEDSDMDCETLTVIEDGCNVDSTVYIPFARNTSKKHSPLCKRLSPQPKLSVAAAQLVSGSAQTSKGESKPRAPAVCSSRNEAEDAPGDLSSTYDTEDVQLLRKIKEAIGKIPAAAEHAKEQATHHGPSAHPSPGVPVKGSIVPDSSFLNSDLMSDWSISSFSTFTSHDEQDFRNGLAALDANIARLQKSLKTGLLEK
What is the function of this protein?
Negatively regulates centriole duplication.  Negatively regulates CEP63 and CDK2 centrosomal localization.
What are the official names of this protein?
Coiled-coil domain-containing protein 14.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle.
Protein: Y1025_RICBR
Sequence: MFDDKLSKDLLLSARANNNLAVIRILQDTTSAINPNLQDENGKTALHWAVINLNPLITCYILKIEKVNVNIQDNTGFTVLHYLAKTISNLKFTTINGSFYKSNNYSILKTLFEYGIDVNIQDNKGNTALHYAICKNNFFFIEELLSNNASPFILNKAGFSILYKLNTKNCNFKDEIIESLHSKYPESIELGLVDNKIIIYDIHKLLYNLPYFMYEHNILILGNDA
What are the official names of this protein?
Putative ankyrin repeat protein RBE_1025.
Protein: KCY_FLAJ1
Sequence: MKKITIAIDGFSSTGKSTLAKQLAKELEYVYVDTGAMYRAVAYFAMQNKFIGADFFNKEALIEALPKIQLEFKFNSDLGFAEMYLNGENVEKQIRTIEVSNFVSKVAEVSEVRSKLVEQQQEMGTNKAIVMDGRDIGTVVFPNAELKIFMTASAETRAQRRFDELQQKGDNVSYEDVLKNVVERDYIDTHREDSPLVIADDAIEIDNSYLNKEEQFAAVLELVNDVVKID
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF1_ORYSJ
Sequence: MGDGERREDENPTTSAADDDDDEDYDEPGGGNHFLGFMFGNVDDSGDLDADYLDEDAKEHLFALADKLGPSLKDIDLIKPSAAPTDPSEQDYDAKAEDAVDYEDIDEEYDGPEVEAATEEDHLLSKKDYFSSNAVYASVNSKVSVFDEENYDEDEEPPNDNDLPSDNIVQNCTSASAEQLDMAPSNDNLAVEKMSSSLSEPEESFESEAFQKEMVAEEQLESKTATSLPVLCIEDGSVILKFSEIFGAQEPVRKAKMDRHKRPVNKELQITNFTDIVEEDEEVFLRSTIQNLSALKHIKTNDNFVESDSDESTSDVALRLKDSCLSEQPMKDKDIPTAVQSPVFPDFYPLEHENWENDIVWGNSPTTAIQPCLTSCAISKESLDDHNEDQAEGYVSGCWDVQNKFHSSSVMADPFGHTEIPDSTSYRSPENSYSPLRKETAQENNSLDEPNNITQPVKIDTTRHLNKLSLLNKELLEGSWLDNIVWDPSEDVPKPKLIFDLKDDHMLFEILDEKNGDHLRSHARAMIVTRPMKTSAVENVDHNNQAIALSGRFNISNDKFYSNRKMSQQARSHAKKRATMGLKLVHSVPAQKLQTMKPKLSIKEIANFHRPKAKWYPHENKLTARFQGDECSHGPMTAIVMTLGGKGVKFLVNAEETPLSVKSKASKKLEFKPSEKIKLFCSGKELQDDISLAMQNVRPNSILHVVRTEIHLWPKAQRLPGENKPLRPPGAFRKKSDLSVKDGHVFLMEYCEERPLLLANAGMAARLCTYYQKTSPSDQTATSLRSNSDGLGTMLAIDPADKSPFLGNIRSGSHQSCLETNMYRAPVFPHKVATTDYLLVRSPKGMLSLRRIDKLYAVGQQEPHMEVFSPGTKNMQNYILNRILVYVYREFRAREKPGIIPQIRADELPIQPPITEAIVRKRLKHCADLRKGPKGHLFYIQRPDFRIPSEEELRRLLTPENVCCYESMQAGQYRLKHLGIEKLTQPVGLASAMNQLPDEAIELAAAAHIERELQITSWNLTSNFVACTNQDKENIERLEITGVGDPSGRGLGFSYVRVTPKAPVSNSTHKKKSAAAKGTTVTGTDADLRRLSMDAARELLLKFGVPEEQIDKLTRWHRIAMVRKLSSEQAASGVTMDEIPVSKFARGQRMSFLQLQQQTKEKCQEIWDRQIQSLSAMDGNENGSDTEANSDLDSFAGDLENLLDAEEFDDEDVGNTDIRSDKMDGMRGLKMRRCHTQSQINEEIQDDVAEAALVEKLLEESDSDMKRKKQPVETTNYSTPMYNQGNKMKQGKAGQMIKSSVYAGALTPKESIPREAKEVENFAEGSLPSKLRTKTGFDANDDIILVKRKNIPGKDGFKEKRQGARGDTLVCGACGQLGHMRTNKLCPKYGEDPETSEMDVNSIRSHPPDIVSNAQIKTSNKRLVAKVSSEAFETEGPESIEKAKPVPVKFKCGAPEKSLDRNMSISASLVSDKRMMDATDSKSTGKVNKIKISNKIKYDDYPPDTPKPSVVIRPPAEVEKDLPRKKIIIKQPKVLGDQQRPTELRSGQEPRKTRKIVELSSFEKRDREDDNGFSGQPIQINSSHDRGWGLVGKRSKGIMESSESWRAFEEQRERQEQRLIEARIYDARREDELQKAKKKNKKKKKHEFRDDDLLDPRPYKNDRRVPERGRAAKRRTPADMTEYTPPAKRHRGGEVELSNILEKIVDHLRTMSCSFLFRKPVTKKEAPDYFDIIERPMDLGTIRDKVRKMEYKNREDFRHDVAQIALNAHTYNLNRHPHIPPLADELLELCDYLLEESADVLDDAEYAIED
What is the function of this protein?
Largest component and core scaffold of the TFIID basal transcription factor complex.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 1, TAFII250.
What is the protein family that this protein belongs to?
Belongs to the TAF1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAP1_RAT
Sequence: MADMQNLVERLERAVGRLEAVSHTSDMHCGYGDSPSKGAVPYVQAFDSLLANPVAEYLKMSKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSDLLAPISEQIQEVITFREKNRGSKFFNHLSAVSESIQALGWVALAAKPGPFVKEMNDAAMFYTNRVLKEYRDVDKKHVDWVRAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSGLPSGPSVGSGPPPPPPGPPPPPVPTSSGSDDSASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKPATKKEPALLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSRDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG
What is the function of this protein?
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
What are the official names of this protein?
Adenylyl cyclase-associated protein 1, CAP 1.
What is the protein family that this protein belongs to?
Belongs to the CAP family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ILVB1_BRANA
Sequence: MAAATSSSPISLTAKPSSKSPLPISRFSLPFSLTPQKDSSRLHRPLAISAVLNSPVNVAPPSPEKTDKNKTFVSRYAPDEPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSTIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADAMLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVDDIPRIVQEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWDQPMRLPGYMSRLPQPPEVSQLGQIVRLISESKRPVLYVGGGSLNSSEELGRFVELTGIPVASTLMGLGSYPCNDELSLQMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRSELSEQKQKFPLSFKTFGEAIPPQYAIQILDELTEGKAIISTGVGQHQMWAAQFYKYRKPRQWLSSSGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKILLLNNQHLGMVMQWEDRFYKANRAHTYLGDPARENEIFPNMLQFAGACGIPAARVTKKEELREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFKDVITEGDGRTKY
What are the official names of this protein?
Acetolactate synthase 1, chloroplastic, ALS I, Acetohydroxy-acid synthase I, Acetolactate synthase I.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y262_SPHAL
Sequence: MTRAAAEARGRRAERRAAWWLRLHGWRIVGQRLRVPVGEVDLVARRGRTVAFIEVKWRDRAADLDLAIDPYRLRRVAAAAEMLAPRFARPYDDIRIDVMLLAPRRLPRHLVHVWQP
What are the official names of this protein?
UPF0102 protein Sala_0262.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: ABC3G_PANTR
Sequence: MKPHFRNPVERMYQDTFSDNFYNRPILSHRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSKLKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDVATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTSNFNNELWVRGRHETYLCYEVERLHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLHQDYRVTCFTSWSPCFSCAQEMAKFISNNKHVSLCIFAARIYDDQGRCQEGLRTLAKAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLEEHSQALSGRLRAILQNQGN
What is the function of this protein?
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms.  Exhibits antiviral activity against vif-deficient: HIV-1 and simian immunodeficiency viruses (SIVs) and also against simian foamy virus (SFV).  After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA.  The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.  Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.  May inhibit the mobility of LTR retrotransposons.
What are the official names of this protein?
DNA dC->dU-editing enzyme APOBEC-3G, Deoxycytidine deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic, small amount are found in the nucleus.
Protein: HOA2_PSEFK
Sequence: MKLEGKKVTVHDMTLRDGMHPKRHQMTLEQMKSIACGLDAAGIPLIEVTHGDGLGGSSVNYGFPAHSDEEYLGAVIPLMKQAKVSALLLPGIGTVEHLKMAKDLGVNTIRVATHCTEADVSEQHITQSRKLGLDTVGFLMMAHMASPEKLVSQALLMQGYGANCIYVTDSAGYMLPDDVKARLSAVRAALKPETELGFHGHHNLAMGVANSIAAIEAGATRIDAAAAGLGAGAGNTPMEVFIAVCARMGIETGVDVFKIQDVAEDLVVPIMDHVIRIDRDSLTLGYAGVYSSFLLFAKRASAKYGVPARDILVELGRRGMVGGQEDMIEDTAMTMARERGLTLTAA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 2, HOA 2, 4-hydroxy-2-keto-pentanoic acid aldolase 2, 4-hydroxy-2-oxopentanoate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: Y3441_DESHY
Sequence: MPRPMKWRKVCCLPESNRFGPLDLNAGDQNQVKMTVDEYETIRLIDLEGFTQEECAKKMNVARTTVQGIYIEARKKLAESLVNGKVLQIEGGEYRLCDGLGNGCGQGCYKRRRRMGCSGKEEGED
What are the official names of this protein?
UPF0251 protein DSY3441.
What is the protein family that this protein belongs to?
Belongs to the UPF0251 family.
Protein: PYRF_ALBFT
Sequence: MTFLDMLRAAERQNGSMLCVGLDPEPTRFPAHYSGDVSKIYDFCAAIVDATADLVMAFKPQIAYFAAHRAEPQLERLIAHMRRAAPHVPVILDAKRGDIGSTAEQYAKEAFERYGADAVTLSPFMGFDSLQPYLRYHGKGAFLLCRTSNPGGDDLQSQRLASVEGTPLLYEHIARLAQGPWNLNGQLGLVVGATYPAELERVRALAPTLPLLIPGVGAQGGDCAATVRAAWRAAPGTSGEALDTLAPIIVNSSRAILYASSGADFAQAARREALATRDLLQAARQPA
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: LPXK_PHOPR
Sequence: MAALIEKFWFGHHPKGLMLLLNVLFWPVFWPLSKLFGFISVRRRNKYQTGEKVAYRAPVPVVVVGNITAGGNGKTPVVVWLVEQLQAKGLKPGVVSRGYGGKAPHYPYLVEDKTSTDLVGDEPVLIRRRTGAPVAVSPIRSDAVMMLLEHDVDVIITDDGLQHYALARDIEFVVIDGQRRFGNQQLLPLGPLRETCDRLADVDFLICNGGKAQKNEAPMHLQPSALINVKTGERCSINELENIVAMAGIGHPPRFFKTLEELGVTPVHCQPFTDHQAFSETELKHLAQQGQHLVMTEKDAVKCHAFAQSNWWYVPVDAVIPTSNATAIINRIIKVKEEYGSPSA
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: TAM_ACIET
Sequence: MHDWDPALYQRFESERTRPAVELLARVSHPAPRHIVDLGCGNGNSTQLLLERFPQSQLIGLDNSEAMLASARKRLPGVPFVQADIADWAPTVAPDLIFANASLQWVAGHAGLFARLMRCLAPGGVLAVQMPDNLDQPSHQLMRELASQSAWRDQLAHAADQRAALLSVEAYYDLLAPMACRVDIWHTAYRHVMPSVQAIVEWLESTGLKPFLDPLSAVLRDAYLQAYTQRIGEAYTKRADGHRLFAFPRLFIVAQRAP
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_ACTP7
Sequence: MAKQIKKIAVLTSGGDAPGMNAAIRGVVRAALNEGLEVYGVQDGYYGLYTDRVIPLDRRSVSETINRGGTFLGSARFPQFKDPDVRKKSVETLKKYDIDALVVIGGDGSYMGAKLITEEFGYPCIGIPGTIDNDIVGTDYTIGYQTALETAVEAIDRLRDTSTSHQRISIVEIMGRHCGDLTISAALASGCEYIIVPEKGLDKESLMRNIEDGFNKGKRHAIIAITELMTDVQALAKEIEDRFGHETRATVLGHIQRGGAPCPFDRILASRMGVYAVDLLLQGHGGRCIGIKNENLVHHDIIDAINNMRRPFKEELFEAARKLF
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACH23_CAEEL
Sequence: MHRIYTFLIFISQLALGLSNNPDIPIQYELANNIMENYQKGLIPKVRKGSPINVTLSLQLYQIIQVNEPQQYLLLNAWAVERWVDQMLGWDPSEFDNETEIMARHDDIWLPDTTLYNSLEMDDSASKKLTHVKLTTLGKNQGAMVELLYPTIYKISCLLNLKYFPFDTQTCRMTFGSWSFDNSLIDYFPRTFTNGPIGLANFLENDAWSVLGTKVNREEKKYTCCPVNYTLLHYDVVIQRKPLYYVLNLIAPTAVITFISIIGFFTSVNPFTNFCNVSSSVHDLRQEKITLGITTLLSMSIMIFMVSDKMPSTSTCVPLIALFYTLMITIISVGTLAASSVIFVQKLGSIGNPPASKTMKWTHRIAPFVLIQMPLVMKQAYAKRAKEEKHRKRMSRKNSMWTKVYHLARDHSKLMETVPDGAVKFNQISDFKNNDIGNMESPRMAESQTSETFAAPMDTSFTESLHIPELNRVASSNSIQSVLKPTEIQLTPYCTRNIVELEWDWVAAVLERVFLIFFTICFLFSAIGINLYGWYIWYTENHFLF
What is the function of this protein?
Betaine receptor that functions as a ligand-gated non-selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion.  The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions.  Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA.
What are the official names of this protein?
Betaine receptor acr-23, Acetylcholine receptor subunit alpha-type acr-23.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL5_AZOVD
Sequence: MARLKEIYRNEIAPKLKNELQLVNVMEVPRITKITLNMGLGEAVGDKKVIENAVADLEKITGQKPVVTYARKSIAGFKIREGWPIGVKVTLRRDRMYEFLDRLLSISLPRVRDFRGLNAKSFDGRGNYSMGVKEQIIFPEIDYDKIDALRGLDITLTTTARTDDEGRALLRAFNFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: Y05O_BPT4
Sequence: MKFSDFSQSGKPSKADEYLGLLMAAQAYFHSAHFETKSYARHKAYDFIFSELPDLIDKFGEQYLGYSGRKYTPSIPDASKLPTDTIKMIDRILDQSNSIYKEMPPAIQSTIDDITGMFYQSKYLLSLE
What are the official names of this protein?
Uncharacterized 14.6 kDa protein in mobD-ri intergenic region.
Protein: AZUR_PSEAE
Sequence: MLRKLAAVSLLSLLSAPLLAAECSVDIQGNDQMQFNTNAITVDKSCKQFTVNLSHPGNLPKNVMGHNWVLSTAADMQGVVTDGMASGLDKDYLKPDDSRVIAHTKLIGSGEKDSVTFDVSKLKEGEQYMFFCTFPGHSALMKGTLTLK
What is the function of this protein?
Transfers electrons from cytochrome c551 to cytochrome oxidase.
What are the official names of this protein?
Azurin.
What are the subcellular locations of this protein?
Periplasm.
Protein: GPDA_RALSO
Sequence: MRISVLGAGAWGTALASHAAQSHDVVLWGRDAALVAQMAATRANERYLPGIPLHASLRFEAEMSAALDHATGEDALVVIASPVAGLADLTRGVAAHGGVRNVIWLCKGFDPESGALPHAIVAGVLAQTGRADLATGALSGPSFAKEVAQGLPCAMTVASASTALCTRTQRAFHHHAMRVYASDDLVGVEVGGAVKNVLAIATGAADGLGLGLNARAALVTRGLAEMTRLGTALGGRPETFMGLTGMGDLLLTATGDLSRNRTVGMQLAQGRSLDEILAHLGHVAEGVRCARAVAALARAKGVDMPITFAVCEVLFDGLAPSRAVDRLLQRDAKAESVR
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_BIFLD
Sequence: MQELEERIQSEGTVKAGNVLKVDAFLNHQCDVRLFDRMGSAWAAHFAGKHITKILTIEASGIGIACVAAQHFGNVPVVFAKKAQSINLDGDQYTTTVYSFTKQKEFPVIVAKKYLNAGDHVLLIDDFLANGKALRGLIDLCEAAGATVEGIGIAVEKGFQGGGDALRAEGYDVDSLAIVESMNPETGEITFRH
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PVK2_THEPT
Sequence: GSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, ThePe-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MOSMO_DANRE
Sequence: MDKLTIISGCLFLAADIFAIASIANPDWINTGGQEGALTVGLVKQCQTIHGRNRICVSPSLPPEWVTTLFFIILGIVSLTITCGLLVISHWRREATKYARWIAFMGMVLFCMAALIFPVGFYINQVGGQPYKLPNNTVVGSSYVLFVLSIFFTIVGLLFAGKVCLPG
What is the function of this protein?
Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane.  Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation.
What are the official names of this protein?
Modulator of smoothened protein, Attenuator of hedgehog.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein.
Protein: DNAA_ECO5E
Sequence: MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADAPQLRFEVGTKSVTQTPQAAVTSNVAAPAQVAQTQPQRAAPSTRSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.