PharMolix/UniProtQA huggingface dataset:
Protein: RHG36_MOUSE
Sequence: MAWMLDCLFASAFEPRPRRVSVLGGAPGQNSDRSMDMVSIHSLSELERLKLQETAYHELVARHFLSEFKPDRALPTDRPNTLEKWFLMLRGQDRAASLKTFGIRLEEVLVNELTRRKQRELTPTMQVEDINGSTGRRRRGNVVQRMLGRMRRFFSRRRNEPTLPREFTRRGRRGAVSADSADELENGALLLQILQLSQLSSPIGQRLLGSKRKMSLNPIAQQIPQIVETCCKFIEKHGLSSVGIFTIEYSLRRVLELRELFDKGLDIVLDDSVNVHDVAELLKEFFREMKDPLLPDDLYMSFLLTATLKPKDQVSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGVDGQLVPGNRMTSTNLALVFGTALLKKGKLANKESRKTKLGIDHYVASVNVVRAMIDNWDILFQVPPHIQKEVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVENSAEAQAAILAQSQPFDEDPEGAPDVHEVLNDNLNYDFEDESDFEDQDHLDLAEVPYLDVIPNNEDTDSDADVIPGPSEEPAVPASTAGSPDKEEGAAGNPPNADRPLPRVPQGKKGKFATRFFP
What is the function of this protein?
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
What are the official names of this protein?
Rho GTPase-activating protein 36.
Protein: MEOX1_MOUSE
Sequence: MDPVANSCVRNPQPPAPVWGCLRNPHSEDSSASGLSHYPPTPFSFHQKSDFPATAAYPDFSASCLAATPHSLPRTERIFNEQHPAFPQTPDWHFPISEAGQRLNLGPAGSAREMGAGSPGLVDGTAGLGEDCMVLGTIANETEKKSSRRKKERSDNQENGGGKPEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWFQNRRMKWKRVKGGQPVSPQEQDREDGDSAASPSSE
What is the function of this protein?
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development.  Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:19520072).  Binds specifically to the promoter of target genes and regulates their expression.  Activates expression of NKX3-2 in the sclerotome (PubMed:15024065).  Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation.  While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000).  Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome (By similarity).
What are the official names of this protein?
Homeobox protein MOX-1, Mesenchyme homeobox 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes predominantly in the nucleus.
Protein: WTF6_SCHKA
Sequence: MKNNYTSLKSPIDEEDELKTDHEIDLEKGPLPEYDSEEESTLPPYSDHARLKNPPYTHREKNPSRSTDNSSPFLIKLLISFTSIILFNAPAVCYLKYKDAFFKNYGAAEWTLFGFWCLVCTLALISLTYFYETWTKAVKVTVISLAQCVKACGKGIKHFLKNWRNMIFAFCKSSLFCLVLLKAENELSSHLGDQQWGWKCSASAFTFMAVSSILIFIAETVEPGSCSTDLVKRVQAYCGYEARQYASSNTAIPLHEMNPENEA
What is the function of this protein?
Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons (PubMed:28631612).  Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole (By similarity).  Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote (By similarity).
What are the official names of this protein?
Meiotic drive suppressor wtf6.
What is the protein family that this protein belongs to?
Belongs to the WTF family.
What are the subcellular locations of this protein?
Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: Y634_CHLMU
Sequence: MRVVKRIAVACYLGITIFSGIAFGYEGSFPSSSLEQNPSGVAIHNRVLFKIDEDTVVTTLDVIHKLNILFYSTCPQLVDSVSARSQYYSAMWPVVLESVINEFLMAADAKEKKIFIDPTSVNQEIEAMFGRDLSPFAKFFDMTPGDIFNVVHRVLVAQRIEGMMVRSRVMLKVTPGMVRDRYQKLVEDASQVSQWTYRVLTIKAGSELLANKIAGKVQERLNEGDSWDKERLAAMVLSQGGQLICSDEFIREDAQLSAAHKKALEEINFPEERCGKALEHASGLKLFVLFDCSTKTLEPLEKMEAQIKQRLMMELAEEEEANYKNKLRARYGFDPSIITQLLSEDAPQLFSLL
What are the official names of this protein?
Uncharacterized protein TC_0634.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_1058/CT_355/TC_0634 family.
Protein: CRCB_RHOPA
Sequence: MAYLLVFVGGGLGAMFRHFINTLSGRLLGTAFPYHTFFINVTGSIVMGLIAGYLAFKGGSSQHFRLFLMTGILGGYTTFSAFSLDAALLYERGAVGLAVVYVLGSVVLAIAGLFGGMALIRAMT
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECR_BACCN
Sequence: MHYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLDMKEDDVLDFAKSLVNAKRNLTYCSVCGHITDRDPCYICDDSHRDQSVVCVVQEPKDVIAMEKMKEYQGVYHVLRGAISPMEGIGPEDINIPQLLKRLQDETVQEVILATNPNIEGEATAMYISRLLKPTGIKVTRIAHGLPVGGDLEYADEVTLSKALEGRREV
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RL32_DESDA
Sequence: MAVQQNKKSRSRKGMRRSHDRVAIPAVIYCSCGEPTVPHCVCPSCGTYKGRQVVAKSDNE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: COAX_MYCTA
Sequence: MLLAIDVRNTHTVVGLLSGMKEHAKVVQQWRIRTESEVTADELALTIDGLIGEDSERLTGTAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGFSVDHDVAIVATGHTAPLLLPELHTVDHYDQHLTLQGLRLVFERNLEVQRGRLKTAR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY2_RHIL3
Sequence: MVFWIAGAVGLAIAYLLGSTPSGYLAGKLIRGIDIREHGSKSTGATNVLRTLGKWPALVVLLVDVLKGVGAVVFARWFYSWFSTLSSGMPPTALDLQSLEPWAVCLTGLAVLLGHGRSVWLNFTGGKSVAAGLGVLLAMSWPVGLGAAMVFGVALAISRIVSLSSMLAALTAIALVCGLEQPLPYRLLVIAGGIYVIARHRTNIRRLLAGTEPRLGKVA
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 2, Acyl-PO4 G3P acyltransferase 2, Acyl-phosphate--glycerol-3-phosphate acyltransferase 2, G3P acyltransferase 2, GPAT 2, Lysophosphatidic acid synthase 2, LPA synthase 2.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MYO2_SCHPO
Sequence: MTEVISNKITAKDGATSLKDIDDKRWVWISDPETAFTKAWIKEDLPDKKYVVRYNNSRDEKIVGEDEIDPVNPAKFDRVNDMAELTYLNEPAVTYNLEQRYLSDQIYTYSGLFLVAVNPYCGLPIYTKDIIQLYKDKTQERKLPHVFAIADLAYNNLLENKENQSILVTGESGAGKTENTKRIIQYLAAIASSTTVGSSQVEEQIIKTNPVLESFGNARTVRNNNSSRFGKFIKVEFSLSGEISNAAIEWYLLEKSRVVHQNEFERNYHVFYQLLSGADTALKNKLLLTDNCNDYRYLKDSVHIIDGVDDKEEFKTLLAAFKTLGFDDKENFDLFNILSIILHMGNIDVGADRSGIARLLNPDEIDKLCHLLGVSPELFSQNLVRPRIKAGHEWVISARSQTQVISSIEALAKAIYERNFGWLVKRLNTSLNHSNAQSYFIGILDIAGFEIFEKNSFEQLCINYTNEKLQQFFNHHMFVLEQEEYMKEEIVWDFIDFGHDLQPTIDLIEKANPIGILSCLDEECVMPKATDATFTSKLDALWRNKSLKYKPFKFADQGFILTHYAADVPYSTEGWLEKNTDPLNENVAKLLAQSTNKHVATLFSDYQETETKTVRGRTKKGLFRTVAQRHKEQLNQLMNQFNSTQPHFIRCIVPNEEKKMHTFNRPLVLGQLRCNGVLEGIRITRAGFPNRLPFNDFRVRYEIMAHLPTGTYVESRRASVMILEELKIDEASYRIGVSKIFFKAGVLAELEERRVATLQRLMTMLQTRIRGFLQRKIFQKRLKDIQAIKLLQANLQVYNEFRTFPWAKLFFNLRPLLSSTQNDKQLKKRDAEIIELKYELKKQQNSKSEVERDLVETNNSLTAVENLLTTERAIALDKEEILRRTQERLANIEDSFSETKQQNENLQRESASLKQINNELESELLEKTSKVETLLSEQNELKEKLSLEEKDLLDTKGELESLRENNATVLSEKAEFNEQCKSLQETIVTKDAELDKLTKYISDYKTEIQEMRLTNQKMNEKSIQQEGSLSESLKRVKKLERENSTLISDVSILKQQKEELSVLKGVQELTINNLEEKVNYLEADVKQLPKLKKELESLNDKDQLYQLQATKNKELEAKVKECLNNIKSLTKELENKEEKCQNLSDASLKYIELQEIHENLLLKVSDLENYKKKYEGLQLDLEGLKDVDTNFQELSKKHRDLTFNHESLLRQSASYKEKLSLASSENKDLSNKVSSLTKQVNELSPKASKVPELERKITNLMHEYSQLGKTFEDEKRKALIASRDNEELRSLKSELESKRKLEVEYQKVLEEVKTTRSLRSEVTLLRNKVADHESIRSKLSEVEMKLVDTRKELNSALDSCKKREAEIHRLKEHRPSGKENNIPAVKTTEPVLKNIPQRKTIFDLQQRNANQALYENLKRDYDRLNLEKHNLEKQVNELKGAEVSPQPTGQSLQHVNLAHAIELKALKDQINSEKAKMFSVQVQYEKREQELQKRIASLEKVNKDSLIDVRALRDRIASLEDELRAA
What is the function of this protein?
Required for cell division.  It is a component of the cdc12 'spot', a structure thought to mark the site of septation.  May work in conjunction with myo3.
What are the official names of this protein?
Myosin type-2 heavy chain 1, Myosin type II heavy chain 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Protein: Y117_HELPJ
Sequence: MAKENLPIVFGPVLSRRFGKSLGVDLSPSKKQCNYNCIYCELGKAKPIERMEEVIKVETLISTIQNALNNLTTPIDVLTITANGEPTLYPHLLELIQSIKPFLKGVKTLILSNGSLFYEPKVQQALKEFDIVKFSLDAIDLKAFERVDKPYSKDINKILEGILSFSQIYQGQLVAEVLLIKGVNDSANNLKLIADFLKKINTARVDLSTIDRPSSFKAPKLSEDELLKCSLFFEGLCVSLPKRSTAQAKKLVSCGIDELLALISRRPLSAEEAPLILDPNAFKHLETLLNHKQITIKKVGSLEFYCAF
What are the official names of this protein?
UPF0026 protein jhp_0109.
What is the protein family that this protein belongs to?
Belongs to the UPF0026 family.
Protein: TRXR2_MOUSE
Sequence: MVAAMVAALRGPSRRFRPRTRALTRGTRGAASAAGGQQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHGTQFLKGCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLEPTVTGCUG
What is the function of this protein?
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity).  Maintains thioredoxin in a reduced state.  May play a role in redox-regulated cell signaling (By similarity).
What are the official names of this protein?
Thioredoxin reductase 2, mitochondrial, Thioredoxin reductase TR3.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DBP1_YEAST
Sequence: MADLPQKVSNLSINNKENGGGGGKSSYVPPHLRSRGKPSFERSTPKQEDKVTGGDFFRRAGRQTGNNGGFFGFSKERNGGTSANYNRGGSSNYKSSGNRWVNGKHIPGPKNAKLEAELFGVHDDPDYHSSGIKFDNYDNIPVDASGKDVPEPILDFSSPPLDELLMENIKLASFTKPTPVQKYSIPIVTKGRDLMACAQTGSGKTGGFLFPLFTELFRSGPSPVPEKAQSFYSRKGYPSALVLAPTRELATQIFEEARKFTYRSWVRPCVVYGGAPIGNQMREVDRGCDLLVATPGRLNDLLERGKVSLANIKYLVLDEADRMLDMGFEPQIRHIVEECDMPSVENRQTLMFSATFPVDIQHLARDFLDNYIFLSVGRVGSTSENITQRILYVDDMDKKSALLDLLSAEHKGLTLIFVETKRMADQLTDFLIMQNFKATAIHGDRTQAERERALSAFKANVADILVATAVAARGLDIPNVTHVINYDLPSDIDDYVHRIGRTGRAGNTGVATSFFNSNNQNIVKGLMEILNEANQEVPTFLSDLSRQNSRGGRTRGGGGFFNSRNNGSRDYRKHGGNGSFGSTRPRNTGTSNWGSIGGGFRNDNEKNGYGNSNASWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).  Redundant to DED1, may be required in conditions in which DED1 expression is decreased.
What are the official names of this protein?
ATP-dependent RNA helicase DBP1, DEAD box protein 1, Helicase CA1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAA_LOTJA
Sequence: MIIRSPEPEVKILVDRDPIKTSFEEWAKPGHFSRTIAKGPDTTTWIWNLHADAHDFDSHTSDLEDISRKIFSAHFGQLSIIFLWLSGMYFHGARFSNYEAWLSDPTHIRPSAQVVWPIVGQEILNGDVGGGFRGIQITSGFFQIWRASGITSELQLYCTAIGGLVFAALMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLSWAGHQVHVSLPINQFLNAGVDPKEIPLPHEFILNRDLLAQLYPSFAEGATPFFTLNWAKYADFLTFRGGLDPVTGGLWLTDIAHHHLAIAILFLIAGHMYRTNWGIGHGIKDILEAHKGPFTGQGHKGLYEILTTSWHAQLSINLAMLGSLTIIVAHHMYSMPPYPYLATDYGTQLSLFTHHMWIGGFLIVGAAAHAAIFMVRDYDPTTRYNDLLDRVLRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPIFAQWIQNTHALAPGITAPGATTGTSLTWGGGDLVAVGNKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSISDQGVVTHITGGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLFFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPATQPRALSIVQGRAVGVTHYLLGGIATTWAFFLARIIAVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: HICDH_THET2
Sequence: MAYRICLIEGDGIGHEVIPAARRVLEATGLPLEFVEAEAGWETFERRGTSVPEETVEKILSCHATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKSRPVPGSRPGVDLVIVRENTEGLYVEQERRYLDVAIADAVISKKASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGLAPSGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDLVLERGPRTPDLGGDATTEAFTEAVVEALKSL
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidative decarboxylation of homoisocitrate to 2-oxoadipate (alpha-ketoadipate), a reaction involved in lysine biosynthesis through the alpha-aminoadipate pathway.  In addition, has high activity with isocitrate, but is inactive with 3-isopropylmalate.
What are the official names of this protein?
Isocitrate/homoisocitrate dehydrogenase, Homoisocitrate dehydrogenase, HICDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Protein: CYT5_ARATH
Sequence: MTSKVVFLLLLSLVVVLLPLYASAAARVGGWSPISNVTDPQVVEIGEFAVSEYNKRSESGLKFETVVSGETQVVSGTNYRLKVAANDGDGVSKNYLAIVWDKPWMKFRNLTSFEPANNGRFL
What is the function of this protein?
Specific inhibitor of cysteine proteinases.  Probably involved in the regulation of endogenous processes and in defense against pests and pathogens (By similarity).
What are the official names of this protein?
Cysteine proteinase inhibitor 5, AtCYS-5.
What is the protein family that this protein belongs to?
Belongs to the cystatin family. Phytocystatin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATNI_ARTSZ
Sequence: MGQHIASSESSTNGHVSLETNGDEKTDYSRWRLIDDQGRQSWRYLESDKERVDWPQTTYEKHFLGLDTELPDLTKAQTPLQAAQGAMSYFSQLQLPSGQWASECIGPLFILAFVVIAGYVTDTPLPAGYAVEIRRYLFARQCVADGGWGWHAEASESSAIGTVLSYVVLRLLGTTRDDPRLVRARTLLHEFGGATHAPGLAKFWLCILGVMKWECVNPFLPEFWLSPDSDPASPSKWYLHTRTNFTSMSYVWSKQWSYAGDAITEQLKAELYTQPYDTIDFAGHRSSLAAVDNNYPKWWLVNLMNWLTVAVYIPYFRKPATAESAERKVWDLIVTEDKNTEYIGLSPISKAANLVACYIHDGPDGSSVRAHRRTMGQYFWMTQDGMACNLSDGIQVWDTSLAVQALCAAGASSNPRFQSTLVKAHAFLADHQLLEDVQDQEKCHRWPRKGGWPFSTRYQGYMISECTGEGLRSAMQLQGISHLGLTQRIPEERLRDAVECLLNLQNDTGGFGVYEKRLGSPKLAWLEMGEFVGKTMVTYDYVECTTAAVSALLSFSKLHPNYRAAEIEATTAQGLGFIKQSQKPDGGWYGAWGVCFTYAGMFALETLALAGETYATSEASRRGCDFLLDKQKDDGGWGESYLSLQREEYVQHEESQVVQTAWVCMALMHAGYPGREPIKRGLRLIMSRQQSKGQWYQEALEGGVGDG
What is the function of this protein?
Terpene cyclase/mutase; part of the gene cluster that mediates the biosynthesis of the meroterpenoids arthripenoids (PubMed:29797385).  The pathway begins with the HR-PKS atnH that catalyzes two chain-extension steps to form a reduced triketide, which then primes the SAT domain in the NR-PKS atnG to initiate three more cycles of extension to give a linear hexaketide corresponding to the polyketide part of arthripenoids (PubMed:29797385).  The FAD-dependent monooxygenase atnJ then performs an oxidative decarboxylation at C11 of the atnH/atnG product, via an electrophilic aromatic hydroxylation with concomitant ipso-decarboxylation (PubMed:29797385).  The membrane-bound polyprenyl transferase atnF then introduces a farnesyl group before the FAD-dependent monooxygenase atnK functions as the first epoxidase on terminal C12'-C13' olefin, followed by a second epoxidation on C7'-C8' catalyzed by atnA (PubMed:29797385).  The terpene cyclase/mutase atnI then initiates the sequential tricyclic ring formation through protonation of the terminal epoxide and catalyzes the regioselective and stereoselective 6/6/6-tricyclic ring formation (PubMed:29797385).  The cytochrome P450 monooxygenase atnM is responsible for hydroxylating both C1' and C10' (Probable).  The next steps may involve ketoreduction and acetyl transfer by the ketoreductase atnB and the acetyltransferase atnC, and lead to the production of arthripenoid B, the final biosynthetic product of the atn cluster (PubMed:29797385).  The hydroquinone moiety in arthripenoid B is prone to undergo spontaneous oxidation to afford a benzoquinone compound, a key intermediate for generating structure diversity (Probable).  For instance, addition of a cysteine followed by ring contraction gives arthripenoid A, tautomerization gives the main product arthripenoid C, addition of a molecular of water or amine affords arthripenoid D or E, respectively, and loss of one water forms arthripenoid F (Probable).
What are the official names of this protein?
Terpene cyclase/mutase atnI, Arthripenoid biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: MGLA_SHIFL
Sequence: MVSSTTPSSGEYLLEMSGINKSFPGVKALDNVNLKVRPHSIHALMGENGAGKSTLLKCLFGIYQKDSGTILFQGKEIDFHSAKEALENGISMVHQELNLVLQRSVMDNMWLGRYPTKGMFVDQDKMYRETKAIFDELDIDIDPRARVGTLSVSQMQMIEIAKAFSYNAKIVIMDEPTSSLTEKEVNHLFTIIRKLKERGCGIVYISHKMEEIFQLCDEVTVLRDGQWIATEPLAGLTMDKIIAMMVGRSLNQRFPDKENKPGEVILEVRNLTSLRQPSIRDVSFDLHKGEILGIAGLVGAKRTDIVETLFGIREKSAGTITLHGKQINNHNANEAINHGFALVTEERRSTGIYAYLDIGFNSLISNIRNYKNKVGLLDNSRMKSDTQWVIDSMRVKTPGHRTQIGSLSGGNQQKVIIGRWLLTQPEILMLDEPTRGIDVGAKFEIYQLIAELAKKGKGIIIISSEMPELLGITDRILVMSNGLVSGIVDTKTTTQNEILRLASLHL
What is the function of this protein?
Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Galactose/methyl galactoside import ATP-binding protein MglA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KC2D2_DANRE
Sequence: MALTICTRFTDEYQLFEELGKGAFSVVRRCVKISSGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVHHCHVNGIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEAPKHPWICQRSTVASMMHRQETVECLKKFNARRKLKGAILTTLLVTRNFSAAKSLLNKKPDGVKVNNKTNLASSPKDTGPAPALEPQTTVIHNPVDRNKESTESANTTIEDEDLKARRFGNLSINSIWQPSVGRPQNSEPKQAPNSSVQTCQVINKARKQEIIKVTEQLIESINNGDFEAYAKICDPGLTSFEPEALGNLVEGHDFHRFYFENALSKGNKPVHTILLNPHVHLIGEDAACIAYIRLTQYMDGSGMPRTMQSEETRVWHRRDGKWLNIHFHRSGAPSVPIN
What is the function of this protein?
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system.
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type II delta 2 chain, Calcium/calmodulin-dependent protein kinase type II delta-A chain, CaM kinase II subunit delta-A, CaM-kinase II delta-A chain, CaMK-II subunit delta-A.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Protein: ALFL8_ORYSI
Sequence: MDGGGAHRTPEDVFRDFRARRAGMIKALTTDVEKFYQQCDPEKENLCLYGLPNETWEVNLPAEEVPPELPEPALGINFARDGMDEKDWLSLVAVHSDTWLLAVAFYFGARFGFDKESRKRLFSMINNLPTIYEVVTGTAKKQSKEKTPKTSGKSNKSGTKPSRQPEPNSRGPKMPPPKDEDDSGGEEEEEEEDHENTLCGACGDNYGQDEFWICCDACETWFHGKCVKITPAKAEHIKHYKCPNCSSSSKRARA
What is the function of this protein?
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
What are the official names of this protein?
PHD finger protein ALFIN-LIKE 8.
What is the protein family that this protein belongs to?
Belongs to the Alfin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1176_SULIY
Sequence: MSYLVVTIKVILITGMPGSGKSEFAKLLKERGAKVIVMSEVVRKRYSIEAKPGERLMDFAKRLREIYGDGVVARLCVEELGTSNHDLVVFDGVRSLAEVEEFKRLLGDSVYIVAVHSPPKIRYKRMIERLRSDDSKEISELIRRDREELKLGIGEVIAMADYIITNDSNYEEFKRRCEEVTDRVLKNG
What are the official names of this protein?
UPF0200 protein YG5714_1176.
What is the protein family that this protein belongs to?
Belongs to the UPF0200 family.
Protein: RRP4_PYRHO
Sequence: MKRIFVQNRELVVPGTLLAQGPYKNGRGTFREGSRIYSTVIGLVDIKGNTIRVIPLEGPYIPEVGDNVIGKIVDVKFSSWVVDIGAPYLANLKIQDFTDEKIDLLRTDLRKFFDIGDIIYGKVKAITEVNNIDLTTKGMPFNGGPLKGGQIVKITPSRVPRVIGRGGSMINMIKKLTMTRIIVGQNGWIWVNGKNEALEKLAIEAILKIDRESHTKGLTDRIKSLLLSRLQELKEKGVIEEIPELEEEPQEETEVNNNDGETRRT
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Increases the RNA binding and the efficiency of RNA degradation.  Confers strong poly(A) specificity to the exosome.
What are the official names of this protein?
Exosome complex component Rrp4.
What is the protein family that this protein belongs to?
Belongs to the RRP4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UD17_MOUSE
Sequence: MAPADFPASLPLCVCLLLASGLAQAGRLLVVPMDGSHWFTMQTVVEKLLHKGHEVVVVVPEVSWQLTKPLNFVVKTYAVSHTQEDLNREFKIFIDAQWKSQQEGGILPLLDSPAKGFFELLFSHCRSLFNDKKLVEYLKQTSFDAVFLDPFDVCGLTVAKYFSLPSVVFSRGIFCHYLEDAAQCPSPPSYIPRMLLKFTDTMTFKERTRNLLAYMGERAFCHKFFKSAADIASEVLQTPVTMTDLFSPVSIWLLRTDFVLEFPRPVMPNVIYIGGINCHQGKPLSKEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH
What is the function of this protein?
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile.  Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds.  Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol.  Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties.  Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II.  Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan.
What are the official names of this protein?
UDP-glucuronosyltransferase 1A7, UGT1A7, UDP-glucuronosyltransferase 1-7C, UDPGT 1-7C, UGT1*7C, UGT1-07C, UGT1.7C, UDP-glucuronosyltransferase 1A7C.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.