PharMolix/UniProtQA huggingface dataset:
Protein: IF1_XANC8
Sequence: MSKDDSIEFEGSVSETLPNTTFRVKLENGYEIIAHISGRMRKNYIRILTGDRVKVEMTPYDLTKGRITYRMK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_MYCA9
Sequence: MTIKLHHLRPAPGSKTERTRVGRGEGSKGKTAGRGTKGTKARKNVPVTFEGGQMPIHMRLPKLKGFKNRFRTEYQVVNVADIERLFPEGGDVTIEALVAKGAVRKNELVKVLGNGDLKVKVSVSANKFSDSAREKITAAGGSINEV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: FPG_PSEE4
Sequence: MPELPEVETTRRGIAPHLVGQRVSRVVVRDRRLRWPIPEDLDVRLSGQCIVSVERRAKYLLINAEVGTLISHLGMSGNLRLVELGLPAAKHEHVDIELESGLMLRYTDPRRFGAMLWSLDPLNHELLIRLGPEPLTDLFDGERLFQLSRGRSMAVKPFIMDNAVVVGVGNIYATEALFAAGIDPRREAGGISRARYLKLAIEIKRVLAAAIEQGGTTLRDFIGGDGQPGYFQQELFVYGRGGQPCKVCGTELREVKLGQRASVFCPKCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RDLB_STRCO
Sequence: MIKKVVAYAAIAASVMGASAAAAPQAMAIGDDSGPVSANGNGASQYFGNSMTTGNMSPQMALIQGSFNKPCIAVSDIPVSVIGLVPIQDLNVLGDDMNQQCAENSTQAKRDGALAHLLEDVSILSSNGEGGKG
What is the function of this protein?
Forms part of the rodlet layer on the spore surface; despite their high similarity both RdlA and RdlB are required for rodlet formation (PubMed:12067338, PubMed:15228525).  Plays a role in cell adhesion to polystyrene plates (PubMed:12067338).  Forms amyloid-like fibrils in vitro composed of stacked beta-sheets (PubMed:28211492).
What are the official names of this protein?
Rodlin protein RdlB.
What is the protein family that this protein belongs to?
Belongs to the rodlin family.
What are the subcellular locations of this protein?
Secreted, cell wall. Spore wall. Note=Found on the surface of aerial hyphae and probably on the surface of the spore wall (PubMed:12067338). Rodlins probably contribute to the semi- transparent sheath-like structure which encapsulates spores, probably outside the chaplin layer (Probable).
Protein: INH6_TABYA
Sequence: MLPYWCPLLLAALVLQYATIDAVNYCNLPCRGDRFHVGCGESAFAQECGESPETLDLLKEHTDEILSKINDVRDHVAKGSWGLPMAARMKVVVWDEELARLATRHTKGCLAETHACRNTERFLFPGQLNFEYTDDKLPQTKELIDAAIKKGHLQKHNISREIIESYRDNGPDGNVEELALALSDRVTAVGCGLTTWQDGAKARALLTCNFSSQNTWGRPVYKIGNSPGEKCIEKDETYKNLCSASEPIDPNESN
What is the function of this protein?
Inhibits platelet aggregation induced by all agonists tested (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and snake venom snaclecs (TMVA that activates platelet through GPIB, and stejnulxin that specifically acts through GPVI (GP6))) (PubMed:19531497).  May act by competing with fibrinogen for binding to glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:19531497).
What are the official names of this protein?
Tabinhibitin 6.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: TOM7_MOUSE
Sequence: MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFTRGADPGMPEPSVLSLLWG
What is the function of this protein?
Required for assembly and stability of the TOM complex (By similarity).  Positive regulator of PRKN translocation to damaged mitochondria.  Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity).
What are the official names of this protein?
Mitochondrial import receptor subunit TOM7 homolog, Translocase of outer membrane 7 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the Tom7 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: ITPK1_BOVIN
Sequence: MQTFLKGKRVGYWLSEKKIKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQALELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEENGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTALDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIASVLQGQSSGVAGAGDVAPLKHSRLLAEQAGGLAAERTCSASPGCCSSMMGQEPPWTPEADMGGVGAGSTAKLPHQRLGCTAGVSPSFQQHCVASLATKASSQ
What is the function of this protein?
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.  Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5.  This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not.  Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:8662638).  Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4.  May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium.  Probably acts as the rate-limiting enzyme of the InsP6 pathway.  Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.  Plays an important role in MLKL-mediated necroptosis.  Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation.  Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity).
What are the official names of this protein?
Inositol-tetrakisphosphate 1-kinase, Inositol 1,3,4-trisphosphate 5/6-kinase, Inositol-triphosphate 5/6-kinase, Ins(1,3,4)P(3) 5/6-kinase.
What is the protein family that this protein belongs to?
Belongs to the ITPK1 family.
Protein: PG160_VARV
Sequence: MNCFQEKQFLRENLLKMPFRMVLTGGSGSGKTIYLLSLFSTLVKKYKHIFLFTPVYNPDYDGYIWPNHINFVSSQESLEYNLIRTKSNIEKCITVAQNHKKSAHFLLIFDDVGDKLSKCNTLIEFLNFGRHLNTSIILLCQTYRHVPILGRANITHFCSFNISISDAENMLRSMPVKGKRKDILNMLNMIQTVRSNNRLAIIIEDSVFCEGELRICTDTADKDVIEQKLNIDILVNQYSHMKKNLNTILESTKTKLCNSDQSSSSKNVSS
What is the function of this protein?
Participates in viral DNA packaging and virion morphogenesis.
What are the official names of this protein?
DNA packaging protein OPG160.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG160 protein family.
Protein: TAF6_YEAST
Sequence: MSTQQQSYTIWSPQDTVKDVAESLGLENINDDVLKALAMDVEYRILEIIEQAVKFKRHSKRDVLTTDDVSKALRVLNVEPLYGYYDGSEVNKAVSFSKVNTSGGQSVYYLDEEEVDFDRLINEPLPQVPRLPTFTTHWLAVEGVQPAIIQNPNLNDIRVSQPPFIRGAIVTALNDNSLQTPVTSTTASASVTDTGASQHLSNVKPGQNTEVKPLVKHVLSKELQIYFNKVISTLTAKSQADEAAQHMKQAALTSLRTDSGLHQLVPYFIQFIAEQITQNLSDLQLLTTILEMIYSLLSNTSIFLDPYIHSLMPSILTLLLAKKLGGSPKDDSPQEIHEFLERTNALRDFAASLLDYVLKKFPQAYKSLKPRVTRTLLKTFLDINRVFGTYYGCLKGVSVLEGESIRFFLGNLNNWARLVFNESGITLDNIEEHLNDDSNPTRTKFTKEETQILVDTVISALLVLKKDLPDLYEGKGEKVTDEDKEKLLERCGVTIGFHILKRDDAKELISAIFFGE
What is the function of this protein?
Functions as a component of the DNA-binding general transcription factor complex TFIID and the regulatory transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK.  Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation.  TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.  SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes.  At the promoters, SAGA is required for recruitment of the basal transcription machinery.  It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8).  SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac).  SAGA interacts with DNA via upstream activating sequences (UASs).  SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation.  SLIK is proposed to have partly overlapping functions with SAGA.  It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 6, TBP-associated factor 6, TBP-associated factor 60 kDa, TAFII-60, TAFII60.
What is the protein family that this protein belongs to?
Belongs to the TAF6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TFLM_HUMAN
Sequence: METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEEPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKRKKERKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARIAGLMRSITGSSVSENAAIAMAGIAKVFVGEVVEEALDMCEMWGETPPLQPKHLREAVHRLKPKGLFPNSNYKRVMF
What are the official names of this protein?
TATA-box-binding protein-associated factor 11-like protein 13.
What is the protein family that this protein belongs to?
Belongs to the TAF11 family.
Protein: WECF_YERPE
Sequence: MITLTHVLGSDIPHHNLTVLRFFNDVLAKCLPVEQVRHFMVAAKETAPFSSFPQLDINTYSDKKALAEAVIARAQADRSARFFWHGQFNVTLWLALLSGKIKPGQVYWHVWGADLYEDAKSLKFRLFYLLRRIAQGRVGHVFATRGDLIHYQQRHPRVPASLLYFPTRMDPALTAINIDKPLAGPMTILVGNSGDTTNRHIEALKAIHQQFGPDVRVIIPMGYPANNEAYIEQVRQAGLALFSQDNLRILTEQIPFDDYLNILRECDLGYFIFNRQQGIGTLCLLTQFGVPFVLSRKNPFWQDLAEQHIPVFFYGDTLDEPMIREAQRQLAGLDKQAIAFFNPNYIEGWKQALALAAGEHP
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LACB2_FELCA
Sequence: ATLPPTMEDLDIRQVAGTWHSMAMAASDISLLDSETAPLRVYVQELRPTPRDNLEIILRKRENHACIEGNIMAQRTEDPAVFMVDYQGEKKISVLDTDYTHYMFFCMEAPAPGTENGMMCQYLARTLKADNEVMEKFDRALQTLPVHIRIILDLTQGKEQCRV
What is the function of this protein?
Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
What are the official names of this protein?
Beta-lactoglobulin-2, Beta-LG-2, Beta-lactoglobulin II.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MRAY_BACC7
Sequence: MLEQGLLVTAGVAFLISVALSPLFIPFLRKLKFGQSIRDEGPKSHQKKSGTPTMGGIVIYVSMMVTSLIMAIKFNHLGAEVSLLLLVTFGYGLIGFLDDYIKVVKKRNLGLTSKQKLVGQLVIAIAFFLIGKGQAFHTYIMIPGTDVKFELGWAYFVLVLFMLIGGSNAVNLTDGLDGLLSGTAAIAFGAFSIIAVAQEQFGVAIFCMAVVGAVLGFLVFNANPAKVFMGDTGSLALGGAIAAVAILLKQELLLVIIGGVFVMETLSVIIQVISFKTTGKRVFKMSPLHHHYELCGWSEWRVVVTFWSVGFLLAVLGIYIGVWM
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYV_RICPR
Sequence: MKEFPKHYNFTENEKKWQNIWQELQIYAYDPNISKAEIYIVDTPPPTVSGQLHIGHIYSYTQTDFIVRFQRMIGKNIFYPIGFDDNGLPTERLVEKQKQIKAYNMERDEFIKICLEVVKNEEAKFRSLFKQIALSVDWSLEYQTISPLSRKISQMSFLDLLHKGEVYRANQPILWDTVDGTALAQADIEDKQKISSMNYITFKTEQGDQLTIATTRPELLPACVAVFYHPDDVRYKHLADKSAITPLFNEKVPILADPLVQQDKGTGLVMCCTFGDQTDITWWKSHNLPLKTIITKKGTINFPHKLDIDGLTIKEARTKIIDILKEQSLLTKQEEIIQTVKCAERSGAPLEILTVTQWFIKTITHKEALLKRTNELNWYPKNMKMRLENWINSLSWDWCISRQRYFGVPFPIWYSKRIGEEGKILYADISQLPVDPLKDLPIGYSKEEVDPDLDVMDTWATSSVSPQLSTYGISEDLAINKVRHDKLFPMDLRPQAHEIIRTWAFYTILKSHLHQNILPWKNIMVSGWCLAEDRSKMSKSKGNVLVPEKLLERYGADVIRYWSANSKLGADTAYSEDVMKNGKRLVNKLWNAAKFVSIHFDKLTSEDKKVSLFDIKEKITNEFDQWMINKLVALVKLATNALQNYEYANAIYLTEKFFWSIFCDNYLEISKTRSYDEANKNPQGQYSSILTLYHIMQTLLKLFAPFMPHITEELYQILYNKNSIHMQGNWINYGDLNYEIDVQGPEGLLEILDIVRKFKAEYNLSIKAPIKLLEVSGIVLSTELVEDLKNVTSAEEIQFKAKDDQIKVNIKLFV
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_VIBC1
Sequence: MDALALIMTMAAYLLGSISSAVLICRLLRLPDPRKVGSNNPGATNVLRIGGKGAAVAVLLCDMLKGTIPVWGGYFLGIDPIILGVIAIAACLGHMYPIFFHFKGGKGVATALGAIAPIGLDLTGLVMLTWLSVAVLFRYSSLAALVTVLVTPFYTWMFKPQYTLPVAMLCCLIVFKHHQNIRRLLSGEEPKIGEKKLIEKNSA
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OPSD_BOVIN
Sequence: MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Required for photoreceptor cell viability after birth (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins (PubMed:10926528, PubMed:12044163, PubMed:11972040, PubMed:16908857, PubMed:16586416, PubMed:17060607, PubMed:17449675, PubMed:18818650, PubMed:21389983, PubMed:22198838, PubMed:23579341, PubMed:25205354, PubMed:27458239).  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:1396673, PubMed:15111114).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: RS8_GEOSE
Sequence: MVMTDPIADMLTAIRNANMVRHEKLEVPASKIKREIAEILKREGFIRDYEYIEDNKQGILRIFLKYGPNERVITGLKRISKPGLRVYVKAHEVPRVLNGLGIAILSTSQGVLTDKEARQKGTGGEIIAYVI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, BS8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RL14_EXISA
Sequence: MIQQESRLKVADNSGARELLTIKVLGGSGRKTANIGDIIVATVKQATPGGVVKKGDVVRAVVVRTKRGARRKDGSYIRFDENAAVIIKDDKSPRGTRIFGPVARELREKEFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: Y1427_STAEQ
Sequence: MNDKWYRHIIGARTIKTGLATFFTSLFCMLLNLTPIFAILTAIVTIEPTAKASLKKGYKRLPATVIGALFAVVFTYVFGDQSPLSYALSATFTILICTKLNLQVGTTVAVLTSVAMIPGIHEAYVFNFFSRLLTALIGLVTAGLVNFIILPPKYYHQLEEQLALSEKKMYRLFYERCNELLLGKFSSEKTSKELSKLNIIAQKVETLMSYQRDELHYHKNEDNWKLLNRLTNRAYNNRLFISHLSNIIYLPKHTSIAFDANEKIALINISNSINGIIQKGSFARQKKSIATLKSSVKQMDEFDQNQMKSTLIYEILLIYKILDSRYAK
What are the official names of this protein?
UPF0421 protein SERP1427.
What is the protein family that this protein belongs to?
Belongs to the UPF0421 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTH_STRMK
Sequence: MAGLRLIVGLGNPGSEHARTRHNAGFHFVEALAEKAGARWNVDSKLFGETAKVEIAGQTVWLLKPATFMNLSGKSVTAAQRFWKIEPEETLLAHDELDLAPGVARLKFDGGHGGQNGLRDTIRLLGHGKFHRLRVGIGHPGHKDRVVGWVLGRPSKEDDVLIARAIDDAIDVMPLAVQGDFSEAMKRLHTPK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUBR1_ARATH
Sequence: MAAETKVQVSDPEAEFLNSKQETGYEWELFKENVRPLKRGRNVGILNHALKSHSDHQLRKNLIEKRRNLIEAIDEYEGDDPLSPWIECIKWVQEAFPPGGECSGLLVIYEQCVRKFWHSERYKDDLRYLKVWLEYAEHCADAEVIYKFLEVNEIGKTHAVYYIAYALHIEFKNKVKTANEIFNLGISRDAKPVEKLNDAYKKFMVRTMRRSNTADEEPKENNDLPSRSFGTLLSRGDNNARRQALGSSNPQAKKLKPNQSSKTPFAIYADAVSDTTSGNQPESDKSRPEFGSWLMLGGRAERNKENNSLPRKWASFKVPQKPIVRTVAAASASTFEVFVDEEECTEEEEEKKKNDETISSSSNVLPLNGGREIKKETELLRQNPLRHFPPNSFLR
What is the function of this protein?
Essential component of the mitotic checkpoint.  Required for normal mitosis progression.  The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle.  One of its checkpoint functions may be to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C (By similarity).
What are the official names of this protein?
Mitotic spindle checkpoint protein BUBR1, BUB1-related protein 1.
What are the subcellular locations of this protein?
Chromosome. Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Cytoplasmic in interphase cells. Accumulates onto both kinetochores and the spindle microtubules in cell arrested in metaphase. Associates with unattached kinetochores in early prophase upon spindle assembly checkpoint (SAC) activation. Present in chromocenters.
Protein: HIS4_RUBXD
Sequence: MGPREPFVVFPAIDLKGGRCVRLRQGDFGRERVYDADPVGRAREWERRGARALHVVDLDGAREGRPVQLALIREIARAAGVPLQVGGGIRTLEDVRAARRAGAARVVVGTAAVADRDFRLRALEELGADLVVAVDAREGVVATHGWQRQSGVGAAELAGELAAEGVRAVLFTDISRDGTGEGAALERTAEVAGIIPTIASGGVRGAGDIRALARTPGVVGAVVGTALYEGQATLEELLAAAGG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URED_SACD2
Sequence: MNAILPKISTLPAKPAPTREWLAGIDLLLAKRYQRTALMSSKHFGPLRVQRPFYPEPDGCCHIYLLHPPGGLVIGDNLHIGASLQQGAQALITTPSAGKLYGAKGASEKQGQQVEFNLAAESCLEWLPQETIIFDGANGTLSTKVNLTGNAQYFGWDIIRLGRVASGEPFNTGTCAQRLQLWRDGLPLFIEKTKFEASSNMHREKWGLQNANTCATLTATLQLTRDSIDEMLEALAQLGVTNTGEWGLTQKESLFIVRYLGNSITDCRKGFEFIWQQTRAVFNGKPAEVPRIWRT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEMP1_MOUSE
Sequence: MAGGIKVSVWSAVGPGPRCWGAGGGGGATWLLLVVAGCVVCGSADVNVVMLQESQVDMNSSQQFCYKNVLIPKWHDIWTRIQVRVNSSKLVRVTQVDNEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEMIEKDTTYSVTVTRRFDPKLFLVFLLGLTLFFCGDLLSRSQIFYYSTGMSVGIVASLLIVIFMISKFMPKRSPIYVILVGGWSFSLYLIQLVFKNLQEIWRSYWHYLLSYILTVGFMSFAVCYKYGPLENERSINLLTWTLQLLGLGLMYSSIQIPHVAFALIVIALCTKNLEYPIHWLCSTYRRMCKASGKPVPPRLLTEEEYRIQGEVETQKALQELREFCNSPECSAWKTISRIQSPKRFADFVEGSFHLTPNEVSVHEQEYGLGSIFTQDEELSSEEEGSEYPTFTQNNFLT
What is the function of this protein?
Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640).  Required for female fertility (PubMed:32923640).
What are the official names of this protein?
Nuclear envelope integral membrane protein 1.
What is the protein family that this protein belongs to?
Belongs to the NEMP family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side. Nucleus envelope. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope.
Protein: PSBT_ADICA
Sequence: MEALVYTFLLVATLGIIFFAIFFREPPKVPNRGK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.