PharMolix/UniProtQA huggingface dataset:
Protein: MANF_ASPFU
Sequence: MHPLPSVALLSAIGAVAAQVGPWGQCGGRSYTGETSCVSGWSCVLFNEWYSQCQPATTTSTSSVSATAAPSSTSSSKESVPSATTSKKPVPTGSSSFVKADGLKFNIDGETKYFAGTNAYWLPFLTNDADVDSVMDNLQKAGLKILRTWGFNDVNSKPSSGTVYFQLHDPSTGTTTINTGADGLQRLDYVVSAAEKRGIKLLIPLVNNWDDYGGMNAYVKAYGGSKTEWYTNSKIQSVYQAYIKAVVSRYRDSPAIMAWELSNEARCQGCSTDVIYNWTAKTSAYIKSLDPNHMVATGDEGMGVTVDSDGSYPYSTYEGSDFAKNLAAPDIDFGVFHLYTEDWGIKDNSWGNGWVTSHAKVCKAAGKPCLFEEYGLKDDHCSASLTWQKTSVSSGMAADLFWQYGQTLSTGPSPNDHFTIYYGTSDWQCGVADHLSTL
What is the function of this protein?
Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.
What are the official names of this protein?
Mannan endo-1,4-beta-mannosidase F, Endo-beta-1,4-mannanase F.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACP_NEIG2
Sequence: MSNIEQQVKKIIAEQLGVNEADVKNESSFQDDLGADSLDTVELVMALEEAFGCEIPDEDAEKITTVQLAIDYINAHNG
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHAB_ENT38
Sequence: MTLRHCVAVDLGASSGRVMLACYAPEQRTLTLREIHRFVNCLQKQGGVDTWDIDSLEAEIRTGLNKVCEEGILIDSIGIDTWGVDYVLLDRNGARIGLPVSYRDSRTDGVMARAIEQLGKADIYGRSGIQFLPFNTLYQLRALAEQQPELIKNVAHALLIPDYFSYRLTGNMNWEYTNATTTQLVNINSDNWDENLLNWTGVSAAWFGTPTHPGNVIGHWICPLGNQIPVVAVASHDTASAVIASPLASQDAAYLSSGTWSLMGFESKTPYTSDAALAANITNEGGAEGRYRVLKNIMGLWLLQRVLKEQNVSDLSALIADTETLAACRFVINPNDDRFINPANMSTEIQAACRETNQPVPNTPAELARCIFDSLALLYADVLQELATLRGKPFSQLHIVGGGCQNRLLNQLCADACGITVVAGPVEASTLGNIGIQLMTLDELTNVDDFRTVVTGNYALTTFTPHSCHEIARYRAQFQQKRLTKELCA
What is the function of this protein?
Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose).  Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.
What are the official names of this protein?
Rhamnulokinase, RhaB, ATP:L-rhamnulose phosphotransferase, L-rhamnulose 1-kinase, Rhamnulose kinase.
What is the protein family that this protein belongs to?
Belongs to the rhamnulokinase family.
Protein: UPP_CLOB8
Sequence: MSKVIEINHPLILHKLAILRDEKTGSKDFRKLVEEISMLMAYEVTRDLNTEEVEVKTPVAVTKCKMLSGKKMAVVPILRAGLGMVDGVLNLIPAAKVGHIGLYRDEKTLQPVEYFCKMPQDIAERDIIVVDPMLATGGSAIDALTMLKNRGAKNLKLMCLVGAPEGIEAIKKAHDDVDIYLASIDEKLNEHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: LEUC_KINRD
Sequence: MARTLAEKVWDDHVVRKGQDGEPDLLYIDLHLVHEVTSPQAFDGLRAAGRPVRRLDLTIATEDHNTPTVDIDRPLSLLEDKTSAKQLQTLRENCAEFGVRLHPLGDAEQGIVHVVGPQLGLTQPGMTVVCGDSHTSTHGAFGSLGMGIGTSEVEHVLATQTLPLKPFKTMAITVDGTLKPGTTAKDVILAVIAEIGTGGGQGYVLEYRGEAIRNLSMEGRMTICNMSIEAGARAGMVAPDETTFAYLEGRPHAPQGADWDAAVEYWRTLRTDDDAEFDAEVVLDGSALEPFVTWGTNPGQGVPLSGSVPEPERIGDDGVRQGVERALEYMGLEGGTPMRDIAVDTVFIGSCTNSRIEDLRAAADVVRGRRKADSVRVMVVPGSAKVRLQAEAEGIDTVFKEFGADWRFAGCSMCLGMNPDQLAPGERCASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADLEPPVPTNV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: CYB_SPECI
Sequence: MTNTRKTHPLXKIINHSFIDLPAPSNISAWWNFGSLLGLCLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTYFETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVMIHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDILGILLLILTLMMLVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALIFSILILMLFPLLHLSKQRSMMFRPMSQCVFWILVADLLTLTWIGGQPVEHPFVIIGQLASILYFAIILLILPTVSMIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KHSE_PASMU
Sequence: MLRIYAPASSANLSVGFDTLGTAVSPIDGSLLGDVVQIEALPSGFELESAGYFVRKLPKEAQKNIVYQAYVLFSERLKLRNIAVRPLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHAEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGVQLMVQSLGNICQQLPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDVISQARHLGSFVHACHTRQAQLAALMMKDVIAEPYREALLPNFADVKQATRDLGALATGISGSGPTIFAIAPDLGTAMKLSTYLENHYLQNNEGFVHICKVDNQGARALD
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_ECO55
Sequence: MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTBDG_MOUSE
Sequence: MKMLNSVSGSFRKKAGDSRSRECRTRLERRIVGATNRWRFPQDHFCGDLLALSQMCNVLNVDLDEALKNPDRLCISKFQKLFSENIMNSGTQSGEADVILECLGFKWELHHPQIFQSGTLAKLYLTALIQNMKSSQRELDKVQKAHPSGKIKKRSPVKKIIISMRINDPAVTRVAFALALKNLYMKEVEMTVDNVLGVLASAHILQFNRLFQKCVNMMMNRLAPSTIKNFYLAGCKYEEEQLTMACEKWLAMNLVPLVGTQIHLRQIPEPLLYKVLKSPRLFTFSEFHLLKTLLMWVYLQMNCKVQMVPIHETILAFFNSFPKKCCFLEQDPGQNWMPLFLCLRLHGITSGKDLEVLKHINFFPESWLVRVTANHYHALESGGNMVHLKDLSTQAMRFGLLFRQEYTTYSERISIYGYFFEIKGIKHDPTSYSFSMQRIKHTDLECPSPVCEHSTISLRSERLVKYEIQAQTLVDGRWQEFRTNQIMQKFGFIKPGCKSHVLKIQTVGIPIYASFAFIFPAS
What are the official names of this protein?
BTB/POZ domain-containing protein 16.
Protein: H2B_MAGOY
Sequence: MPPKAADKKPASKAPATASKAPEKKDAGKKTAASGDKKKRTKTRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ADD_ECOBW
Sequence: MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVREGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKTFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: CWP01_TOBAC
Sequence: GLVPPADKY
What are the official names of this protein?
70 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RNH2_SHESM
Sequence: MAVFKTLTDADMAIFSAGLVAGVDEVGRGPLVGDVVTAAVILDPNRPIAGLNDSKKLTEKRREALFDEICEKALSYHVGRATPSEIDELNILHATMLAMQRAVAGLARTPELVLVDGNRSPAFTHQGLSLTSHSIVKGDGLIASISAASIIAKVTRDREMDALDAAYPQYGFAKHKGYPTKAHFDAIAEHGVFDQYRKSFKPVKALLER
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_CAPBU
Sequence: MVREKVKVSTRTLQWKCVESRRDSKRLYYGRFILSPLMKGQADTIGIAMRRALLGEIEGTCITRAKSENIPHDYSNIVGIQESVHEILMNLNEIVLRSNLYGTRNALICVQGPGYITARDIILPPSVEIIDNTQHIATLTEPIDLCIELKIERNRGYSLKMSNNFEDRSYPIDAVFMPVQNANHSIHSYGNGNEKQEILFLEIWTNGSLTPKEALHEASRNLINLFIPFLHVEEETFYLENNQHQVTLPFFPFHNRLVNLRKKTKELAFQYIFIDQLELPPRIYNCLKKSNIHTLLDLLNNSQEDLIKIEHFHVEDVKKILDILEKK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BGLA_THEMA
Sequence: MNVKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSISWPRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIYHWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVRFMHQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSGHLVKFDPDAPAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGLED
What are the official names of this protein?
Beta-glucosidase A, Beta-D-glucoside glucohydrolase, Cellobiase, Gentiobiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: OV39_ONCVO
Sequence: IEAAKSSNNCAVPPFVGDLPIAENKEVLSIWKDYKSGEDCSNQRRETQQVIDDLPDEVRAMVFGRLPSFLNGASTDVKKMFRAIMYNRTLNYDLKKQELSKLAEEILSKKQLAEF
What are the official names of this protein?
OV39 antigen.
Protein: MIAA_BARQU
Sequence: MTQRTITLIAGPTVSGKSALALQMAQKKNALIINTDSMQVYDVLNILTARPTEADTAIVPHYLYGYVSPALHYSVGQWLCDVRKLLTTFTSKSLIFVGGTGLYFRALLEGLSEIPHISDAVRQKWRLRLDKEGAENLYRQLLRIDAVFAEKISSQDGQRIIRALEVYDVTGKKLSWWQKKKTPPLISPNCSEKILLIPPRQWLYERIHKRLDNMIERGALEEVFAMKKLMLSPFLPAMKAIGMPEFTAYFDGYKSFEDALEMAKTQTRRYAKRQMTWFRNQFDEEWTLISSCEEV
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: PINR_ECOL6
Sequence: MSRIFAYCRISTLDQTTENQRREIESAGFKIKPQQIIEEHISGSAATSERPGFNRLLARLKCGDQLIVTKLDRLGCNAMDIRKTVEQLTETGIRVHCLALGGIDLTSPTGKMMMQVISAVAEFERDLLLERTHSGIVRARGAGKRFGRPPVLNEEQKQVVFERIKSGVSISAIAREFKTSRQTILRAKAKLQTPDI
What are the official names of this protein?
Putative DNA-invertase from lambdoid prophage Rac.
What is the protein family that this protein belongs to?
Belongs to the site-specific recombinase resolvase family.
Protein: GR57A_DROME
Sequence: MAVLYFFREPETVFDCAAFICILQFLMGCNGFGIRRSTFRISWASRIYSMSVAIAAFCCLFGSLSVLLAEEDIRERLAKADNLVLSISALELLMSTLVFGVTVISLQVFARRHLGIYQRLAALDARLMSDFGANLNYRKMLRKNIAVLGIVTTIYLMAINSAAVQVASGHRALFLLFALCYTIVTGGPHFTGYVHMTLAEMLGIRFRLLQQLLQPEFLNWRFPQLHVQELRIRQVVSMIQELHYLIQEINRVYALSLWAAMAHDLAMSTSELYILFGQSVGIGQQNEEENGSCYRMLGYLALVMIPPLYKLLIAPFYCDRTIYEARRCLRLVEKLDDWFPQKSSLRPLVESLMSWRIQAKIQFTSGLDVVLSRKVIGLFTSILVNYLLILIQFAMTQKMGEQIEQQKIALQEWIGF
What is the function of this protein?
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
What are the official names of this protein?
Putative gustatory receptor 57a.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr57a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FKB1A_RABIT
Sequence: MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
What is the function of this protein?
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand.  Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.  May modulate the RYR1 calcium channel activity.  PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP1A, PPIase FKBP1A, 12 kDa FK506-binding protein, 12 kDa FKBP, FKBP-12, Calstabin-1, FK506-binding protein 1A, FKBP-1A, Immunophilin FKBP12, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRG_SYNS9
Sequence: MAKFVFITGGVVSSIGKGIVAASLGRLLKSRGYNVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTDTAMSRLNSVTTGSIYQSVINKERRGAYNGGTVQVIPHITGEIRERIHRVAANSGADVVITEIGGTVGDIESLPFLEAIREFRGDVGRQDLAYIHVTLLPFIGTSGELKTKPTQHSVKELRSIGIQPDVLVCRSDREISEDLKRKIGGFCGVPNRAVIPSLDADTIYAVPLTLEEGGLCREVLDVLQLTDHESDMTAWSQLVHNLRNPGPSVKVALVGKYVQLNDAYLSVVEALRHACIAQDASLDLHWVCAEQIETEGADALLRGMDAVVVPGGFGNRGVDGKIAAIRWAREQRVPFLGLCLGMQTAVIEWARNQAGLPEATSEELDPGTPHPVIHLLPEQQDVVDLGGTMRLGVYPCRIAPDTLADRLYGEQVVYERHRHRFEFNNAYRSLFLEAGYVVSGTSPDGRLVELIELKGHPFFTACQYHPEFLSRPGRPHPLFRGLIEAAQQRLPDSPAQAIRNQGEVTTP
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: UPP_RHIE6
Sequence: MDGVTVIDHPLVQHKLTIMRRKETSTGSFRRLLREISTLLCYEVTRDLELTMETIETPLQTIESPILEGKKLVFASILRAGNGLLEGMLDLVPSARVSHIGVYRDHETLQPVEYYFKAPEDVAERLIIVVDPMLATGNSSIAAIDKLKERGAHNIRFLCLLAAPEGIRNFRAAHPDVPVFTAAIDSHLNEKGYIVPGLGDAGDRMYGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: GRIA3_HUMAN
Sequence: MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
What is the function of this protein?
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission.  L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.  Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.  The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.  In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
What are the official names of this protein?
Glutamate receptor 3, GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression.
Protein: PTH_RICRO
Sequence: MLLVIGLGNPGKEYQYTRHNVGFIAIEKIANQYNSSFSTKKKFNCEIAETISYGQKIIFIKPTTYMNLSGKSVISVKTYYNIYPAKSFVIHDDIDLETGRVKFKTGGGNGGHNGLKSIDGVIGNNYNRIRIGVGRPQNNQDLADYVLNHFSKPEYKTVMQAIDRITSNFGLILENKLEEFKNKMA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUI1_THEVO
Sequence: MKDKNFTGMPKELQPWEGFGREAQAVKIVVDKRRYGKFVTIIEGIDPKIEDIEKIAKELKKKVASGGTVKEGRIIELQGDHRQEVKKFLEDMGFKVSVEQ
What are the official names of this protein?
Protein translation factor SUI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: NDK_SHIDS
Sequence: MAIERTFSIIKPNAVAKNVIGNIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLEGENAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSVESAAREIAYFFGEGEVCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRK_METBF
Sequence: MLPLNATIVQINEESPLVRTFFFDFQFETMEPGQFVMVWVRGVDEVPMGLSSKNSITVQKVGEATSKLFELKEGDSFGLRGPFGKGFSLPSEGEKTLIIAGGVGAAPLAPYAEAARSAGSEVHTVLGARSAGDLLFEKRFAEAGKVYISTDDGSKGTKGFVTDVLTDLDLSVYDRIAVCGPEIMISSVFRLLKDRQVLEKSEFSLQRYFKCGIGVCGACCIDKSGLRVCRDGPVFSGVQLLDSELGKYARDASGRRVKI
What is the function of this protein?
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
What are the official names of this protein?
Probable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit, Dihydroorotate oxidase B, electron transfer subunit.
What is the protein family that this protein belongs to?
Belongs to the PyrK family.
Protein: IRX1_MOUSE
Sequence: MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGTAELGAGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTTPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQIDERDGDQSNEDEEDKAEAPRARVAPPASARDQSSPLSAAETLKSQDSPLGLVKEVSEPGSTRLLSPGAAAVGLQGAPHSKPKIWSLAETATSPDGAPKASPPPPSSHASAHGPPSGSPLQHPAFLPSHGLYTCHIGKFSNWTNGAFLAQGSLLNMRSFLGVSAPHAAPHGPHLTAPPPPQPPVQVATGVLHGEKASARSSPALPERDLVTRPDSPPQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
What are the official names of this protein?
Iroquois-class homeodomain protein IRX-1, Homeodomain protein IRXA1, Iroquois homeobox protein 1.
What is the protein family that this protein belongs to?
Belongs to the TALE/IRO homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HROB_MOUSE
Sequence: MTCGFQKLFSVEEDFEDEDFLSALENAENHVVSALPRDAGCLRPVSSRPQETVQTQSSRPVPSYPTSNQSVPRLCLPPSSMRENAKAPLSTGVMSLRPASISSSSLSSQQRMTGAKVFQESSGPQPSAAHSGYIFESHQQGIGDFEAPDQDDLDKALASMEFEGAGLELEADSGATQILPAKHCEDPVLAKKARVADLSGSLRKEPMVHCRNPWPSLRPTSATGSLPVPATSCVSTSQQRGSPAPAPQYLPVAGRTIRSSPQNYGPGQPLQSPRAWSSGKPRFSGPQRPHGSSAAFCQGPLSSRAPVSSVESPVSTPRNTSTPVTQPALQTPVVTNHLVQLVTATNRTPQQPSRPSIRAKTRRFPGPAGLLPHQHSGENLEEIMVSTPQTPTHGALAKFQTEIATSSQGSVEEDFGQGPWLTMKSALGLDEGDPTCFLYTYSIVMVLRKAALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMLGTVHRVLLETHQSELRPGSVLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSLDSGDGDFLEPPQPLPKDLGNSHGSLQPDVAAEPTRGLRTAQNPAVAFPEEELSEADDLDGLLSELPEDFFCEPSS
What is the function of this protein?
DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis.
What are the official names of this protein?
Homologous recombination OB-fold protein.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localized to the sites of DNA damage.
Protein: SIGA_MYCTU
Sequence: MAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKPASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHATKPRAPKDAQHEAATDPEDALDSVEELDAEPDLDVEPGEDLDLDAADLNLDDLEDDVAPDADDDLDSGDDEDHEDLEAEAAVAPGQTADDDEEIAEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth (Probable).
What are the official names of this protein?
RNA polymerase sigma factor SigA, Sigma-A.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.