Protein: BADA_BARHN
Sequence: MKKLSVTSKRQYNLYASPISRRLSLLMKLSLETVTVMFLLGASPVLASNLALTGAKNLSQNSPGVNYSKGSHGSIVLSGDDDFCGADYVLGRGGNSTVRNGIPISVEEEYERFVKQKLMNNATSPYSQSSEQQVWTGDGLTSKGSGYMGGKSTDGDKNILPEAYGIYSFATGCGSSAQGNYSVAFGANATALTGGSQAFGVAALASGRVSVAIGVGSEATGEAGVSLGGLSKAAGARSVAIGTRAKAQGEESIAIGSSVKNGDKDGSAVAQGAKAIAIGSNSISFQHYAVAVGAKAHALLSKTVALGYDSVADVDAGIRGYDPVEDEPSKDVSFVWKSSLGAVSVGNRKEGLTRQIIGVAAGTEDTDAVNVAQLKALRGMISEKGGWNLTVNNDNNTVVSSGGALDLSSGSKNLKIVKDGKKNNVTFDVARDLTLKSIKLDGVTLNETGLFIANGPQITASGINAGSQKITGVAEGTDANDAVNFGQLKKIETEVKEQVAASGFVKQDSDTKYLTIGKDTDGDTINIANNKSDKRTLTGIKEGDISKDSSEAITGSQLFTTNQNVKTVSDNLQTAATNIAKTFGGGAKYEDGEWIAPAFKVKTVTGEGKEEEKRYQNVADALAGVGSSITNVQNKVTEQVNNAITKVEGDALLWSDEANAFVARHEKSKLGKGASKATQENSKITYLLDGDVSKDSTDAITGKQLYSLGDKIASYLGGNAKYEDGEWTAPTFKVKTVKEDGKEEEKTYQNVAEALTGVGTSFTNVKNEITKQINHLQSDDSAVVHYDKNKDETGGINYASVTLGKGKDSAAVTLHNVADGSISKDSRDAINGSQIYSLNEQLATYFGGGAKYENGQWTAPIFKVKTVKEDGEEEEKTYQNVAEALTGVGTSFTNIKSEITKQIANEISSVTGDSLVKKDLATNLITIGKEVAGTEINIASVSKADRTLSGVKEAVKDNEAVNKGQLDKGLKHLSDSLQSDDSAVVHYDKKTDETGGINYTSVTLGGKDKTPVALHNVADGSISKDSHDAINGGQIHTIGEDVAKFLGGAASFNNGAFTGPTYKLSNIDAKGDVQQSEFKDIGSAFAGLDTNIKNVNNNVTNKFNELTQNITNVTQQVKGDALLWSDEANAFVARHEKSKLGKGASKATQENSKITYLLDGDVSKDSTDAITGKQLYSLGDKIASYLGGNAKYENGEWTAPTFKVKTVKEDGKEEEKTYQNVAEALTGVGASFTNVKNEITKQINHLQSDDSAVVHYDKNKDETGGINYASVTLGKGKDSAAVTLHNVADGSISKDSRDAINGSQIYSLNEQLATYFGGGAKYENGQWTAPIFKVKTVKEDGEEEEKTYQNVAEALTGVGTSFTNIKSEITKQIANEISSVTGDSLVKKDLATNLITIGKEVAGTEINIASVSKADRTLSGVKEAVKDNEAVNKGQLDTNIKKVEDKLTEAVGKVTQQVKGDALLWSNEDNAFVADHGKDSAKTKSKITHLLDGNIASGSTDAVTGGQLYSLNEQLATYFGGGAKYENGQWTAPTFKVKTVNGEGKEEEQTYQNVAEALTGVGASFMNVQNKITNEITNQVNNAITKVEGDSLVKQDNLGIITLGKERGGLKVDFANRDGLDRTLSGVKEAVNDNEAVNKGQLDADISKVNNNVTNKFNELTQNITNVTQQVKGDALLWSDEANAFVARHEKSKLEKGVSKATQENSKITYLLDGDISKGSTDAVTGGQLYSLNEQLATYFGGGAKYENGQWTAPTFKVKTVNGEGKEEEQTYQNVAAAFEGVGTSFTNIKSEITKQINNEIINVKGDSLVKRDLATNLITIGKEIEGSVINIANKSGEARTISGVKEAVKDNEAVNKGQLDTNIKKVEDKLTEAVGKVTQQVKGDALLWSNEDNAFVADHGKDSAKTKSKITHLLDGNIASGSTDAVTGGQLYSLNEQLATYFGGGAKYENGQWTAPTFKVKTVNGEGKEEEKTYQNVAAAFEGVGTSFTNIKSEITKQIANEISNVTGDSLVKKDLDTNLITIGKEIAGTEINIASVSKADRTLSGVKEAVNDNEAVNKGQLDANISKVNNNVTNKFNELTQSITNVTQQVKGDALLWSDEANAFVARHEKSKLEKGVSKATQENSKITYLLDGDISKGSTDAVTGGQLYSLNEQLATYFGGGAKYENGQWTAPTFKVKTVNGEGKEEEQTYQNVAAAFEGVGTSFTNIKSEITKQINNEIINVKGDSLVKRDLATNLITIGKEIEGSVINIANKSGEARTISGVKEAVKDNEAVNKGQLDTNIKKVEDKLTEAVGKVTQQVKGDALLWSNEDNAFVADHGKDSAKTKSKITHLLDGNIASGSTDAVTGGQLYSLNEQLATYFGGGAKYENGQWTAPTFKVKTVNGEGKEEEKTYQNVAAAFEGVGTSFTHVKNEITKQINHLQSDDSAVVHYDKDDKNGSINYASVTLGKGKDSAAVALHNVADGSISKDSHDAINGGQIHTIGEDVAKFLGGDAAFKDGAFTGPTYKLSNIDAKGDVQQSEFKDIGSAFAGLDTNIKNVNNNVTNKLSELTQNITTVTQQVKGNALLWSDEANAFVARHEKSKLEKGASKAIQENSKITYLLDGDVSKGSTDAVTGGQLYSMSNMLATYLGGNAKYENGEWTAPTFKVKTVNGEGKEEEQTYQNVAEALTGVGTSFTNIKSEIAKQINHLQSDDSAVIHYDKNKDETGTINYASVTLGKGEDSAAVALHNVAAGNIAKDSRDAINGSQLYSLNEQLLTYFGGDAGYKDGQWIAPKFHVLQFKSDGSSGEKESYDNVAAAFEGVNKSLAGMNERINNVTAGQNVSSSSLNWNETEGGYDARHNGVDSKLTHVENGDVSEKSKEAVNGSQLWNTNEKVEAVEKDVKNIEKKVQDIATVADSAVKYEKDSTGKKTNVIKLVGGSESEPVLIDNVADGKIEADSKQAVNGGQLRDYTEKQMKIVLDDAKKYTDERFNDVVNNGINEAKAYTDVKFEALSYTVEEVRKEARQAAAIGLAVSNLRYYDIPGSLSLSFGTGIWRSQSAFAIGAGYTSEDGNIRSNLSITSSGGQWGVGAGITLRLK
What is the function of this protein?
Mediates bacterial adherence to host endothelial cells and host extracellular matrix proteins (collagen type I, III, IV, laminin and fibronectin).  Static versus dynamic adherence results differ slightly; in dynamic adherence studies bacteria bind to fixed components under a constant defined flow rate to simulate in vivo infection conditions (PubMed:15534369, PubMed:17060468, PubMed:18627378, PubMed:21536788, PubMed:23163798).  Induces secretion of host proangiogenic cytokines such as VEGFA, ADM, IGFBP-3 and IL-8.  May prevent bacterial phagocytosis by macrophages (PubMed:15534369) (Probable).  Probably mediates bacterial autoagglutination (PubMed:17060468, PubMed:18627378).  Negatively impacts type IV secretion system effectors (VirB/D4 T4SS and its substrate Bep proteins), possibly by preventing close association of host and bacterial cells.  This implies the 2 factors are expressed at different times during infection (Probable).
What are the official names of this protein?
Autotransporter adhesin BadA, Bartonella adhesin A, BadA, Non-fimbrial adhesin A, Type 5 secretion system autotransporter BadA, Type IV pilus.
What is the protein family that this protein belongs to?
Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
What are the subcellular locations of this protein?
Cell surface. Cell outer membrane. Note=Forms long (about 240 nm) filaments extending from the cell surface, which were initially called type IV pili (PubMed:15534369, PubMed:18627378, PubMed:21536788, PubMed:21981119, PubMed:23163798). The C-terminal translocator domain is localized in the outer membrane and the passenger domain is at the cell surface (By similarity).