PharMolix/UniProtQA huggingface dataset:
Protein: ARUC_PSEAE
Sequence: MSAPHAQVERADFDRYMVPNYAPAAFIPVRGEGSRVWDQSGRELIDFAGGIAVTSLGHAHPALVKALTEQAQRIWHVSNVFTNEPALRLARKLVDATFAERVFLANSGAEANEAAFKLARRYANDVYGPQKYEIIAASNSFHGRTLFTVNVGGQPKYSDGFGPKFEGITHVPYNDLEALKAAISDKTCAVVLEPIQGEGGVLPAQQAYLEGARKLCDEHNALLVFDEVQSGMGRVGELFAYMHYGVVPDILSSAKSLGGGFPIGAMLTTGEIAKHLSVGTHGTTYGGNPLASAVAEAALDVINTPEVLDGVKAKHERFKSRLQKIGQEYGIFDEIRGMGLLIGAALTDEWKGKARDVLNAAEKEAVMVLQASPDVVRFAPSLVIDDAEIDEGLERFERAVAKLVRG
What is the function of this protein?
Transaminates both N(2)-acetylornithine and N(2)-succinylornithine.
What are the official names of this protein?
Succinylornithine transaminase/acetylornithine aminotransferase, ACOAT, SOAT, Succinylornithine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_SYNWW
Sequence: MRTYEMMFVLRPDLEEEQVLETKERLQKIIADFGGEFINAADGWGKKRLAYAIDDYVEGIYSLWYFKGKPETVDELDRIIKISENFLRHIIIRQDEK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: BNP_PROFL
Sequence: MFVSRLAASGLLLLALLALSLDGKPVHQSKPGRSPPISPLSAQQWMPEGRPPHPIPPLSVQQWSQGRPRSEVPPVVVQPHESPAGGTTAFREELSPGPEAASGPAAPHRLPKSKGASATSAASRPMRDLRTDGKQERQKWGRMVQPDHHAAPGGGGGGGGGARRMKGLAKKAMGKGCFGHKLDRIGSTSGLGC
What is the function of this protein?
Has a vasorelaxant activity in rat aortic strips and a diuretic potency in anesthetized rats.  Is as potent as Tf-CNP.
What are the official names of this protein?
Bradykinin-potentiating and C-type natriuretic peptides, BPP-CNP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: PUTP_ECOLI
Sequence: MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGLTLGAWINWKLVAGRLRVHTEYNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSLEVIKQKSIENVDMLKGLNFVAIISLMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNDHPALAGAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIALAANPENRVLGLVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVIVWKQFGWLGLYEIIPGFIFGSIGIVVFSLLGKAPSAAMQKRFAEADAHYHSAPPSRLQES
What is the function of this protein?
Catalyzes the sodium-dependent uptake of extracellular L-proline (PubMed:3512540, PubMed:1567896, PubMed:9693004).  This protein is also capable of using lithium as the transport cation (PubMed:1567896, PubMed:9693004).  Also catalyzes the uptake of propionate (PubMed:17088549).
What are the official names of this protein?
Sodium/proline symporter, Proline carrier, Proline permease, Propionate transporter.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SUCC_RHIME
Sequence: MNIHEYQAKALLKSYGAPVAEGVAIFSADEAEAAAKKLPGPLYVVKSQIHAGGRGKGKFKELGPDAKGGVRLAKSVDEVVANAKDMLGNTLVTKQTGPAGKQVNRLYIEDGADIDRELYLSILVDRSVGQVAFVVSTEGGMDIEAVAEHTPEKIVTVAIDPEKGVTAENLKTLADALKLEGEARADAEKLFPILYKAFVEKDMSLLEVNPLIVMTNGRMRVLDAKVSFDGNALFRHEDVVALRDTTEEDDKEIEASKYDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGASKEKVTQAFKIITADPAVKGILVNIFGGIMKCDVIAEGVLAAVKEVGLKVPLVVRLEGTNVELGKKIINESGLNVISADDLDDAAQKIVAAVKGA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: COAE_DEIRA
Sequence: MTRSPAPSSPTHPRRLGLTGSIGAGKSTVARLLRERGLTVLDADAEARWVTEQPEVLTELNEAFPGVVTGGTLDRAGLAARVFSDPAQVARLNAITHPRVRARMEALEAAATARGEHWVVQDIPLLFEGGLERGMDAVLVVDAPLELRLERALARGGLTREDILARDARQLSSEEKRRRATIVLDNSGPLEALEGQLDAALRQLEIT
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXA_YERPA
Sequence: MIDKTAFIHPSSIVEEGAIIGAGVYIGPFCIVGSQVEIGAGTELKSHVVVNGITKIGCDNQIYQFASIGEANQDLKYAGEPTRVEVGDRNRIRESVTIHRGTTQGGGVTKVGCDNLLMVNTHVAHDCVIGNRCILANNAALGGHVEIDDYAIIGGMTAIHQFCVIGAHVMVGGCSGITQDVPPFVIAQGNHATPFGINIEGLKRRGFDKESLHAIRSAYKLLYRSGRTLDEVKPEIAELAEQYPVVKAFNDFFARSTRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NECT3_HUMAN
Sequence: MARTLRPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV
What is the function of this protein?
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions.  Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1.  Also involved in the formation of cell-cell junctions, including adherens junctions and synapses.  Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.  Plays a role in the morphology of the ciliary body.
What are the official names of this protein?
Nectin-3, CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Postsynaptic cell membrane.
Protein: RT07_YEAST
Sequence: MLHCARRYMLVRPRLLWQSGTCVARFQSSVRTPASEPSAEKGVDEWLEAINELREEFSAKEYLPETSLAPPGQSKVDLLQGSQAGSKIKPTAEQLAQWEALKSVPIPPRKNATLDHITNMIMRHGKKEKAQTILSRALYLVYCQTRQDPIQALEKSLDELAPLMMTKTFNTGVAKASVIPVPLNKRQRNRIAWNWIVQSANQRVSSDFAVRLGEELTAIAKGTSSAFEKRDQIHKTAIAHRAYIQLK
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
37S ribosomal protein S7, mitochondrial, Mitochondrial small ribosomal subunit protein uS7m.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Y2093_METPP
Sequence: MVPDAKHAPLPCPCGRPAYDRCCGRHVGTALPAPDAETLMRSRYSAFVLDRREHLLATWHASTRPAAIEPPPPGLRWLGLEVRQHRLTGPDAAEVEFVARSKLAGRAHRLHERSRFVRDQGRWFYLDGEIDPPVAG
What are the official names of this protein?
UPF0225 protein Mpe_A2093.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: Y1705_LISW6
Sequence: MYLPKEKEIIQIKSYKHNGKLHRTWKKTVVLKSTENIIIGGNDHTLVVEADGRKWVTREPSICYFHSDYWFNVISMIREDGIYHYCNLGTPFAVDEQALKYIDYDLDIKVFPDGRFHLLDEGEYEQHRRQMKYPDSIDRILKTNVDVLSHWILDKKGPFSPDYIDIWYEKYKEYR
What are the official names of this protein?
UPF0374 protein lwe1705.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: CP2BC_RAT
Sequence: MEFGVLLLLTLTVGFLLFLVSQSQPKTHGHLPPGPRPLPFLGNLLQMNRRGFLNSFMQLQEKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFATGERWKTLRRFSLVTMKEFGMGKRSVDERIKEEAQCLVEELKKYKGAPLNPTFLFQSIAANTICSIVFGERFDYKDHQFLHLLDLVYKTSVLMGSLSSQVFELYSGFLKYFPGAHKQIFKNLQEMLNYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFNHQNLVISVLSLFFAGTETTSTTLRCTFLIMLKYPHVAEKVQKEIDQVIGSHRLPTPDDRTKMPYTDAVIHEIQRFADLTPIGLPHRVTKDTVFRGYLLPKNTEVYPILSSALHDPRYFEQPDTFNPEHFLDANGALKKSEAFLPFSTGKRICLGEGIARNELFIFFTAILQNFTLASPVAPEDIDLTPINIGVGKIPSPYQINFLSR
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
What are the official names of this protein?
Cytochrome P450 2B12, CYPIIB12.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: VATE_METM7
Sequence: MGAEKITSKIVEDANKNAEKILAEALNEKEAILTEAKEEASKKEQAIAKKGEKDAEMTKNRILAEARLSAKKKLLEEREKTIQLTLEKLEEDLVKLPQKEEYKDILLKLIISGVYSVGGGELELLLNKKDFEVIDDSTLWALEKEMEDRLKKVTVLKKGEAKSIIGGCIIKTADKTKVSDNSLEATFERNLDSVRAKIAEMLF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: LEUD_HERA2
Sequence: MQPINTFQAKAVALPIENIDTDQIIPARYLKVTDKNGLGEALFTDWRGEPDFVLNQPYAQGAGVLIAGHNFGCGSSREHAPWALQGFGFQAVISTYFADIFKGNALKNGLLPIVVDAPTLARLTEQCLANQTIDVSVDLENQQVHVAGETISFPIDAFSKHCLLHGVDQLGYIQAQETAIQAYEASHAARVNTVGA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: Y352_GLUOX
Sequence: MLHYAIVFFIISIIAGVFGFSGISAATAGIAKLFFIVFLVLAVLAILAGVAGLHAL
What are the official names of this protein?
UPF0391 membrane protein GOX0352.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROA_YERPG
Sequence: MLESLTLQPIALVNGTVNLPGSKSVSNRALLLAALAEGTTQLNNVLDSDDIRHMLNALQALGVDFRLSADRTCCEVDGLGGKLVAEQPLSLFLGNAGTAMRPLAAVLCLGNSDIVLTGEPRMKERPIGHLVDALRQGGAQIDYLEQENYPPLRLRGGFRGGELTVDGRVSSQFLTALLMTAPLAEQDTTIRIMGDLVSKPYIDITLHLMKAFGIDVGHENYQIFHIKGGQTYRSPGTYLVEGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGAKVTWGDDYIECSRGELQGIDMDMNHIPDAAMTIATTALFATGPTTIRNIYNWRVKETDRLTAMATELRKVGAEVEEGEDYIRVVPPLQLTAADIGTYDDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQFARLSQLA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BLA3_KLEPN
Sequence: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
What is the function of this protein?
This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
What are the official names of this protein?
Beta-lactamase SHV-3.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: DNAG_PYRAE
Sequence: MGALTIVAKYMIVAQIEVNGSVDKSDIIGALFSQTEGLLGKDMDLRELQMMGRIGRIEVDIFEKNGKTKAKIHIPSNLDRYETALVAALIESIERVGPYPAAVKVVEIRDLREEKRKKIIEKAKELVKLIEEEILPDTKEIIEKLKEDVAKAEIIEYGPERLPAGPDVDKSDSIIIVEGRADVVNLVKHGYRNVIALEGISRGVPQTIIELSKKKNVTVFIDGDKGGELVLRELLKVAHVDYIARAPPGKEVEQLTAKEIAKALRNKITLEEWLAQQKAAGEKAETPQQPPPQQPVPQQEVREEAQKPAFPFDITKKIDEMLGTLEAEIYDENWTLVKRLPVRELPDFLTTSGDSIYAIILDGITTQRIVDLAAKKGVKIIVTARTGPLTKVPENMQILTFDQLKKVE
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Also part of the exosome, which is a complex involved in RNA degradation.  Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: RPOB_STAEQ
Sequence: MAGQVVQYGRHRKRRNYARISEVLELPNLIEIQTKSYDWFLKEGLLEMFRDISPIEDFTGNLSLEFVDYRLGEPKYDLEESKNRDATYAAPLRVKVRLIIKETGEVKEQEVFMGDFPLMTDTGTFVINGAERVIVSQLVRSPSVYFNEKIDKNGRENYDATIIPNRGAWLEYETDAKDVVYVRIDRTRKLPLTVLLRALGFSTDQEIVDLLGDSEYLRNTLEKDGTENTEQALLEIYERLRPGEPPTVENAKSLLYSRFFDPKRYDLASVGRYKANKKLHLKHRLFNQKLAEPIVNSETGEIVVDEGTVLDRRKLDEIMDVLETNANSEVFELEGSVIDEPVEIQSIKVYVPNDEEGRTTTVIGNALPDSEVKCITPADIVASMSYFFNLLNGIGYTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTDSITPQQLINIRPVIASIKEFFGSSQLSQFMDQANPLAELTHKRRLSALGPGGLTRERAQMEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSYARVNEFGFIETPYRKVDLDTNSITDQIDYLTADEEDSYVVAQANSRLDENGRFLDDEVVCRFRGNNTVMAKEKMDYMDVSPKQVVSAATACIPFLENDDSNRALMGANMQRQAVPLMNPEAPFVGTGMEHVAARDSGAAITAKHRGRVEHVESNEILVRRLVEENGTEHEGELDRYPLAKFKRSNSGTCYNQRPIVSIGDVVEYNEILADGPSMELGEMALGRNVVVGFMTWDGYNYEDAVIMSERLVKDDVYTSIHIEEYESEARDTKLGPEEITRDIPNVSESALKNLDDRGIVYVGAEVKDGDILVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGAGGIVLDVKVFNREEGDDTLSPGVNQLVRVYIVQKRKIHVGDKMCGRHGNKGVISKIVPEEDMPYLPDGRPIDIMLNPLGVPSRMNIGQVLELHLGMAAKNLGIHVASPVFDGANDDDVWSTIEEAGMARDGKTVLYDGRTGEPFDNRISVGVMYMLKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTYKSDDTVGRVKTYESIVKGENISRPSVPESFRVLMKELQSLGLDVKVMDEHDNEIEMADVDDEDAAERKVDLQQKSAPESQKETTD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: LPPX_MYCLE
Sequence: MNDRKWVTSSVMLVTLSACLALGLSGCSSTKPDAQEQSSSSSPASSDPALTAEIKQSLETTKALSSVHVVVQTTGKVDALLGISNADVDVQANPLAVKGTCTYNDQPGVPFRVLGDNISVKLFDDWSNLGSISDLSTSHVLDPNTGITQVLSGVINLQAQGTEVVDRIPTNKITGTVPTSSVKMLDPKAKGSKLATVWIAQDGSHHLVRASIDLGSGSIQLTQSKWNEPVNTN
What is the function of this protein?
Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall.
What are the official names of this protein?
Putative phthiocerol dimycocerosate transporter LppX, Lipoprotein LppX.
What is the protein family that this protein belongs to?
Belongs to the LppX/LprAFG lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cell surface. Secreted, cell wall. Secreted.
Protein: APE1_AERPE
Sequence: MDGYALFYLVGALRDGSVYRYSRNYYVIWYSSNKDYLERVIVSKLRILGFHNVRVYQYKRGAYRVRISSKQLFHILVNQFEHPLSTSSRKTPWPTPQRVKDGPLALQIEYVKGFVDAEGSVIKSSKGVQVDVSQQIMEPLKFLAQVLEKVGVKVTGIYLGSDGVWRLRIASLASLRRFAHYIGFRHPCKSKKLNELLGRPLPGPSKLKGIGGGAPQGVEPAA
What is the function of this protein?
Endonuclease involved in 16S rRNA intron I-alpha homing.  Recognizes the minimal target 5'-GCAAGGCTGAAACTTAAAGG-3'; generates 4 base 3' protruding ends 5'-AAAC-3' and 5'-GTTT-3'.
What are the official names of this protein?
Homing endonuclease I-ApeI, rRNA intron-encoded homing endonuclease 1.
Protein: LCB4_YEAST
Sequence: MVVQKKLRAILTDEGVLIKSQSHHMFNKHGQLRSGDSLSLLSCLSCLDDGTLSSDGGSFDEDDSLELLPLNTTIPFNRILNAKYVNVGQKGFNNGKISSNPFQTENLSSSSENDDVENHSLSNDKAPVSESQSFPKKDKWDTKTNTVKVSPDDSQDNSPSLGIKDNQQLIELTFAVPKGHDVIPQKLTLLIDHVSRKSRANTGEENISSGTVEEILEKSYENSKRNRSILVIINPHGGKGTAKNLFLTKARPILVESGCKIEIAYTKYARHAIDIAKDLDISKYDTIACASGDGIPYEVINGLYRRPDRVDAFNKLAVTQLPCGSGNAMSISCHWTNNPSYAALCLVKSIETRIDLMCCSQPSYMNEWPRLSFLSQTYGVIAESDINTEFIRWMGPVRFNLGVAFNIIQGKKYPCEVFVKYAAKSKKELKVHFLENKDKNKGCLTFEPNPSPNSSPDLLSKNNINNSTKDELSPNFLNEDNFKLKYPMTEPVPRDWEKMDSELTDNLTIFYTGKMPYIAKDTKFFPAALPADGTIDLVITDARIPVTRMTPILLSLDKGSHVLEPEVIHSKILAYKIIPKVESGLFSVDGEKFPLEPLQVEIMPMLCKTLLRNGRYIDTEFESM
What is the function of this protein?
Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively (PubMed:9677363, PubMed:11102354, PubMed:11795842, PubMed:16141212, PubMed:25345524).  Involved in the biosynthesis of sphingolipids and ceramides (PubMed:12493772).  Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle.  Involved in heat-induced transient cell cycle arrest (PubMed:11056159).  Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling (PubMed:11278643).  Involved in heat-stress resistance (PubMed:11967828).
What are the official names of this protein?
Sphingoid long chain base kinase 4, LCB kinase 4, Sphinganine kinase 4.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=LCB4 is synthesized in the cytosol, palmitoylated at the Golgi apparatus by AKR1, and then transported to the plasma membrane (PM) via the late Sec pathway. Most of the LCB4 is delivered further to the cortical ER (cER), which is closely adjacent to the PM. In stationary phase, G1 cell cycle arrest causes ER-localized LCB4 to be transported to the Golgi apparatus via the early Sec pathway, and finally to the vacuole via the MVB pathway, where it is degraded.
Protein: FWCH1_MOUSE
Sequence: MPLPEPSEQDCESLRAGQEPSVGARKPQESSNLVPARDKERPKPTDVASQETSSTATLPNNTLQVAPVKKQGRIIHRKRSRVDAVPPQPLEFLKTPFGGRLLVHKSFLYKQEKAVGDKVYWKCRQHSELSCRGRAITRGFRVTEMRDHCHPPEKEGLDRKKRHRGRPPSSALPEGAEVQEDEVSLWLYPVEPEPTPQPSIETPEEEQGYRSLALQSLPPKKRPTPGVVRYRPLEFLKTCYGGTFLVHQSFLYKREKTVGGKVYWTCREHAVHGCRSRAITQGQRVTVMRSHCHSPDIEGLQARRQQEKTIKKIQARRIGAGDLEDCDDIEDSLLQGVDSLFYRRGQGTLTLSRSKSKSKSKSRSKSKSKSRSRSRKRAKKQQESSQEPPEEDQDVDPRGPEFLKTPLGGNFLVYESFLYRREKVAGEKVYWTCRDQARMGCRSRAITQGRQVTVMRSHCHPPDLLGLETLRQREKRPGPSQWDGPEGPEFLKTPLGGSFLVYESFLYRREKATGDKVYWTCRDQARMGCRSRAITQGQRVMVMRRHCHPPDMGGLEALRQRENFPNLTHWEGPEPLQPLEFLRTSLGGRFLVYESFLYRKEKAAGEKVYWMCRDQARLGCRSRAITQGRRVMVMRSHCHPPDLAGLEALRQREKAPSAAKKKKKKKKKKKGIH
What is the function of this protein?
Transcription cofactor.  Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding.  May play a role in DNA-damage response signaling.  Binds specifically to DNA sequences at peri-centromeric chromatin loci.
What are the official names of this protein?
FLYWCH-type zinc finger-containing protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRE_COXBU
Sequence: MNQATEIAKLLLNIKAVTLNLHEPYRYTSGILSPIYCDNRLIISYPEKRKMIIEAFLQLIEKNHLSFDIVAGTATAGIPHAAWIADRLDLPMIYVRAKAKTHGKQNQIEGRIRKGQRALIVEDLISTGKSALAAGLALREKGVTVTDCIAIFSYQLPQAQQNFSDANINCHALSHFDTLIEMAVDEGYIDEIEKQKALAWNKDPEHWQP
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PEPB_ECOSE
Sequence: MTEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKIDGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVEWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGEDLREQGYMGLHTVGRGSERSPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPEMIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASASQENEPFWRLPLAEFHRSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCYB_ONCHC
Sequence: MDALLTSPFIPLKKPSHNRKSNTTTASSSSSSFLQLIPQTKKETLDFDLPRYNTLISPTLDLAVVGGGPAGLAVAKRVSDAGLSVCSIDPYPNLVWPNNYGVWVDEFAAMDLLDCIDASWNSASVFIDDNNRKLLSRPYARVDRRRLKSRLLNAYLSNGVRFHQSKVLNVVHEEAKSVLLCSDGTRIPAAVVLDATGFSRCLVQYQQPYNPGYQVAYGILAEVEEHPFELDQMVFMDWRDSHLGFRPELKKRNDGLPTFLYAMPFSSDLIFLEETSLVARPGLLIEDIQERMIERLRHLGIRIKRIEEDERCVIPMGGPLPVLPQRVLGIGGTAGMVHPSTGYMVARTLAAAPIVADAIVGYIGGSGAEVSARVWKDLWPIERRRQREFFCFGMDVLLKLDLEGTRRFFDAFFGLEERYWHGFLSSRLFLPELVGFGFSLFGRASAGCRLEIMAKGTVPLIKMIRNLLKDLE
What is the function of this protein?
Catalyzes the double cyclization reaction which converts lycopene to beta-carotene and neurosporene to beta-zeacarotene.
What are the official names of this protein?
Lycopene beta cyclase, chloroplastic, OgLCY-B.
What is the protein family that this protein belongs to?
Belongs to the lycopene cyclase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.