PharMolix/UniProtQA huggingface dataset:
Protein: G6PI_LISW6
Sequence: MTHIKFDYSKALRFFEERELDYLEPAVKAAHDSLHNGTGAGNDALGWINLPTDYDKEEFARIKKATEKIHSDSDVLIVIGIGGSYLGARAAIETLNHSFYNVLEKGARKTPQVFFAGNSISSSYLHDLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKELLIKKYGEEGAKKRIYATTDKAKGALKTLSDNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGARAASKDFDKPELKNNISYQYAAARNVLYRKGKVTELLISYEPGLQYLNEWWKQLFGESEGKDKKGIYPSSANFSTDLHSIGQYIQDGRRNLFETVIKVDKPRHNLTINKEEVDLDGLNYLAGETVDFVNTKAFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPGVEAYKANMFALLGKPGFEDKKAELEKRLND
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT29_MOUSE
Sequence: MLTGITRLFSRVQKLDPRCFLHMSVQATQNSQVPAERPRTVSRTSDSDPAKHGEQHEGQHYSIPLQDLKTVFPHGLPPRYMMQVKTFGEACLMVRKPALELLGYLKNTNFAHPAVRYLLYGEKGTGKTLSLCHAVHFCARHDWLILHIPDAHLWVKNCRELLQSTHNKQRFDQPLEASTWLKNFKTTNERFLSQIKVQEKYVWNKRESTEKGSPLGEVVEQGLTRVRNATDAVGVVLKELKAQSALGLFHLLVAVDGVNALWGRTTLKKEDRTLIAPEELSLVHNLRKMVKNDWHGGAIVLSLSQTGSLFKSRTAYLPHELLGKEGFNALEPFLPILIPNYNPKEFESSFQYYLENNWLQHEKASTEEGRKELRFLSNCNPEQLERLCASL
What is the function of this protein?
Involved in mediating interferon-gamma-induced cell death.
What are the official names of this protein?
28S ribosomal protein S29, mitochondrial, MRP-S29, S29mt, Death-associated protein 3, DAP-3.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS29 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CAS3_ECOLI
Sequence: MEPFKYICHYWGKSSKSLTKGNDIHLLIYHCLDVAAVADCWWDQSVVLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFDIRFQYKSAESWLKLNPATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLSEQSLGDFFSFFDAAPHPYESWFPWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDCSSLLAGFCSLADWLGSWTTTNTFLFNEDAPSDINALRTYFQDRQQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPVAPGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSPNLILAHGNSRFNHLFQSIKSRAITEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHTDPVENNSAYPLINWRGVNGAQRFDLLAHPEQLPPRFSIQPEPICLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNTQVDIDLFHARFTLNDRREKENRVISNFGKNGKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRPAGFEIPVATILLPDGEGYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMDEPEWVGNGMDKFESAECEKRFKARKVLQWAEEYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTWKRSFSEVVDEDGLLWLEGKQNLDGWVWQGNSIVITYTGDEGMTRVIPANPK
What is the function of this protein?
Acts as an endonuclease, a 3'-5'exonuclease, and an ATP-dependent dsDNA helicase.  Anneals and unwinds R-loops (in which crRNA binds the target DNA, displacing the noncomplementary strand).  Unwinding requires ATP, annealing does not.  Required along with the Cascade complex for resistance to bacteriophage lambda infection as well as the ability to cure CRISPR-encoding high-copy number plasmid.  A Cas3-CasA fusion protein purified with the Cascade complex nicks target plasmid in the presence but not absence of Mg(2+), and degrades plasmid fully in the presence of Mg(2+) and ATP, suggesting the helicase activity is required for complete degradation.
What are the official names of this protein?
CRISPR-associated endonuclease/helicase Cas3.
What is the protein family that this protein belongs to?
In the central section; belongs to the CRISPR-associated helicase Cas3 family.
Protein: NS1_I02A4
Sequence: MDSNTVSSFQVDCFLWHVRNRFADQELGDAPFLDRLRRDQKSLRGRASTLGVDIETATRAGKQIVERIMEKEFDEALKMTIASLSALRYLTDMTLEEMSRDWFMLMPKQKVAGSLCIRMDQAIMDKTIILKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTDEDVKNAIGVLIGGLEWNDNTVRVSETLQRFAWRSSDEGGRPSLPPKQKRKMARTTESEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: CATIN_ARATH
Sequence: MGSHGKGKRDRSGRQKKRRDESESGSESESYTSDSDGSDDLSPPRSSRRKKGSSSRRTRRRSSSDDSSDSDGGRKSKKRSSSKDYSEEKVTEYMSKKAQKKALRAAKKLKTQSVSGYSNDSNPFGDSNLTETFVWRKKIEKDVHRGVPLEEFSVKAEKRRHRERMTEVEKVKKRREERAVEKARHEEEMALLARERARAEFHDWEKKEEEFHFDQSKVRSEIRLREGRLKPIDVLCKHLDGSDDLDIELSEPYMVFKKKKVRIGIWLNFQLSITNVYVEAEYKNDSACLLLRSRVDILLNKGLTVKDMEELRDDIKMYLDLDRATPTRVQYWEALIVVCDWELAEARKRDALDRARVRGEEPPAELLAQERGLHAGVEADVRKLLDGKTHAELVELQLDIESQLRSGSAKVVEYWEAVLKRLEIYKAKACLKEIHAEMLRRHLHRLEQLSEGEDDVEVNPGLTRVVEENEEEINDTNLSDAEEAFSPEPVAEEEEADEAAEAAGSFSPELMHGDDREEAIDPEEDKKLLQMKRMIVLEKQKKRLKEAMDSKPAPVEDNLELKAMKAMGAMEEGDAIFGSNAEVNLDSEVYWWHDKYRPRKPKYFNRVHTGYEWNKYNQTHYDHDNPPPKIVQGYKFNIFYPDLVDKIKAPIYTIEKDGTSAETCMIRFHAGPPYEDIAFRIVNKEWEYSHKKGFKCTFERGILHLYFNFKRHRYRR
What is the function of this protein?
Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity).  Required for embryogenesis (PubMed:23454656).
What are the official names of this protein?
Splicing factor Cactin.
What is the protein family that this protein belongs to?
Belongs to the CACTIN family.
Protein: NIFZ_AZOCH
Sequence: MLPQFEYGDEVRLIRNVRNDGTYPGMDTGALLIRRGAVGCVYDVGTYLQDQLIYRVHFLNEGRTVGCREEELILASAPWIPNLFEFRDNVIATRSLAVRGQVLVTRGQLGSIMKVLRDESELGIQYHVHFGDGLVLQVPEQSLVMAETEAAMEVLDEL
What are the official names of this protein?
Protein NifZ.
What is the protein family that this protein belongs to?
Belongs to the NifZ family.
Protein: Y4GI_SINFN
Sequence: MKRRVIKMATRASDMHLLNVPLSQPHFFDPHSAWLRHGPFGMWLVHALRPRRIVELGTHYGFSYFCFCQAVAAGDLATECFAVDTWQGDEHAGFYGEEIYHRVMAHNQQYVRFSRLLRKTFTEALDDIEDSSVDLLHVDGRHFYHDVKADFENWIPKLSPRSVVLFHDTEVREHGFGVWQYWAELAAIRPSLNFPYQHGLGMLFWGKEIAEGLAPLARTLTDTERLNWPVEYFALAGESYVRDATQRGVIKRLELAEATIEERKAETVLVQQKLQEARRRPLKQLKRKLVFNMLRAAAKASPPLPSRTAERFRRSAAKRDPMRDDLQTLSGQGFMTYEAVVRGWGKQRQALAGRLSELVRRLQNGPLISVVVPVYNPDPALLVEMIESVRAQSYANWELCLADDCSTDPEVGRVLRNYAAQDPRVRVVFREANGHMSQASNSAIEIARGAYIALLDHDDLLDPDALVLVVQVIDAHPDAKIIYTDEDKIVEGGTRCDAHFKPDWNRDLLYGINYISHLGVFDAALVREVGAFREGFEGAQDYDMLLRCIERVQDRQIHHIAKVLYSWRATPGSAAASNRAKPYANEAGRRALEEHLARTTGKSIPVVLGPIPFSYRALWPMEGTPLVSIIIPTRDHLNVLRATVESILGRTMYGNFELIVVDNGSVEADTLEWFGQIEGSDRRVRVLRDARPFNYSALNNAAVAQSRGEIVALVNDDVEVIAPDWLSEMVALAQRPGVGCVGAKLYYPDGRIQHAGVVIGLGGVAGHGHLLYPGEHAGYFCRLKLRQNYSAVTAACLVIKREIFDAVGGLNESELTVAFSDIDLCLKVRAAGYNNVWTPWAELYHHESASRGHEDTPEKRARFRREVDYMKRRWKTHDFADPAYNPNLALERNDFVLSSPRWCISTKLT
What are the official names of this protein?
Uncharacterized protein y4gI.
Protein: SQHC_SINFN
Sequence: MNKHSGNRTAIDPAALEMSIASATEALLAYRHADGHWAFELEADSTIPSEYILLRHYLAEPIDVVLEAKIGNYLRRTQGAHGGWPLVHDGPFDMSASVKSYFALKMIGDSVDAAHMVKAREAIRARGGAANSNVLTRFLLALYGVVSWRAVPVLPIEIVLLPIWSPFHLYKISYWARTTIVPLMVLAVLKPRAKNPKGVGIEELFLQDTKSVGMNPKAPHQSWGWFLLFRGIDGILRVIEPHLPKKLRERAIASALAFTEERLNGEDGMGAIYPSMANIVMMYDALGKDDHFPPRAIARRAIDKLLVIGEEEAYCQPCLSPVWDTALTCHALQEVGGANAVAKAKQGLDWLKPRQVLDVKGDWAVKAPNIRPGGWPFQYNNAHYPDLDDTAVVVMAMDRAQRHAGSKEYATAIARGREWIEGMQSRDGGWAAFDVNNLEYYLNNLPFADHGALLDPPTEDVTARCVSMLAQVGEFTQRSKAVAEGIAYLRRTQHAEGSWYGRWGLNYIYGTWSVLCALNAAGIDHQDPMIRKAVEWLVSIQSWDGGWGEDAISYRLDYSGYEQAPSTSSQTAWALLGLMAAGEVEHPAVARGVNYLKNAQTENGLWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYRNLRSTNV
What is the function of this protein?
Catalyzes the cyclization of squalene into hopene.  Probably part of an operon y4aABCD involved in the synthesis of an isoprenoid compound.
What are the official names of this protein?
Probable squalene--hopene cyclase, Squalene--hopanol cyclase.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: LPXD_RHOCS
Sequence: MADPRFFRRAGPFSLAQLASLSGAEIAPGADPALLLHDVAPLESAGPEQLSFLDNRKYADAFARTGAGACIVHPDLAGRAPAGTALLLSRKPYRAYALCAQAFYPAPAAEGGVSPGAHLHPTARVGEGTEVAPGAVIEAGAEIGNGCRIGPNAVIGRNVRIGDGTTVGACASLSHCEIGSRVVIYPGVRIGQDGFGFAMDVAGHVRVPQLGRVLVEDDVEIGANVTIDRGAGPDTVIGRGCMIDNLVQIGHNVHLGPGCVVVAQAGISGSTKLDHHVILAAQAGITGHLKIGAGARIAAQSGVMRDVAPGEQVGGSPAVPMRQWLRQVAVLGRLVRGRGDEDNGRNG
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: SURE_XANC8
Sequence: MRVLVSNDDGVDAPGIQILAEALRRAGHEVMVVAPDRDRSGASNSLTLDVPIRTRRIDAQTCAVAGTPTDCVHLALTGMLDYDPDIVVSGINNSANLGDDVIYSGTVSAAMEGRFLGLPAVAVSLVTQNHEAHHFETAARAAVEIVARLKADPLPADTILNVNVPDLAWADVLGFEVTRLGNRHRSEPCVPQNDPRGRTVYWIGPAGPEQDAGAGTDFHAVRTGHISITPIHVDLTRYQALDTVAGWVGGLTAALDAPA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBID_MYCSJ
Sequence: MRGTTSNGAAPSGTGVAVVIAVKRLADAKTRLAPIFAPHDRETVVLAMLVDTVAAAAAVASVTVVTPDPAAAEAARALGAQVLDDPTPAGHPDPLNNALRAAEAAVRATVPNVVALQGDLPALQAQELSEAIAAARTRPRSFVGDRHGTGTSALFAFGVPLDPRFGPDSAERHRRSGAVELTGSWPGLRYDIDTPDDLLAARRLGVGTQTARAVGAER
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
Phosphoenolpyruvate guanylyltransferase, PEP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: DAPB_NITSB
Sequence: MLNVGIYGGSGRVGSLLIKNLQHDEVARVSVVHVLKGIELAVPGATVTNDIDTLIQKSDVIIDFTLPEGTESLLERLLEHPKPLVSGTTGLNKHQQNLMQTLAQKTPVLYATNMSLGIALLKRLVAVTSEKLRDFDIEIVEMHHRYKKDAPSGTALTLAEFAAKARGLDLEKVRVSGRDGNIGERSKEEIGVFALRGGDIVGRHTVGFYNDGEYIELNHTATSRDTFAKGAIKAAKWLVSQEPGFYTIDDCLGL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLI4_CRYNJ
Sequence: MAVHAPYNHAPPPTQEINGQKPTLAPAITLERPADCINRGQYPAFYIICGYLNRLRADAPHKKYELLTRIFGNWREKVGPDLYPLIRLLLPDKDRERPVYNLKESMLARCYIDILSLEKHSEAAQRLIKWKQPAGNSPNPTGDFAKVCYNEIKARSTVEEGQLSVEAVNMLLDKLAVGKMKQKDYVPILKAINMQCTAEEQEWIIRIILKDLHISIRERGVLSAFHPDAIDLYNVCSDLKRVCWTLYDPGFRLNKNETHLELFHSFLPQLCGRMNDASLENIAKAIGAPKEFIMEEKLDGERIQLHMRGNGAQWFYCSRKAKDYTYLYGAHPGEGSLTRYIATAFQDNVRNVILDGEMMVWDPVVERYLAFGTLKSAALAFSLVKVFDILFLNDHCLSRKRLSERKRLLRSGKIFKNIENYKGRLEFVDEKRGKNAKDIREYLERVVETKGEGLVVKKTDVIYQTNSRGYDWIKVKPEYSDQMGENLEVLVLGGWWGKGGRSGKISRLLCGLREQAFDDGTLQDFLFNRFWNELLGLRVDFVSHLMHLRSMRCSPTHLSQCRNKHKKHWRPFDRSNPPPFMKLGPVGLDDKPDVYIEPENSFVIEVKASEIVPAGYGIGFTLRFPRCKYIYYDKNSRDYALDDECLWTVGQGFFYKTRKLIKRTDFMDLFSRPKRSYDDSQGPGNFRGQKLSDADVETSIFSDMTFSDLEALVHKHGADFTQAQLSDLSAIVISPDQKNPLVRAQIRHGVNVIKPEWVFESIARRTALPFLKEFLVFASEEAQDGRYYNKTLEQYDKVSFVRDRTGGALVDEDGDADVEDEIMDGEDKDEIDVEESRESKNRRMAREDLKEKESNRTLEQKKLQEAWGLRSRASPGDSDSEPEEEMSLKEESDTDSERSRGLRAIYEDEEDGENDSHESDVGVNGDDYRAVPLSGLNDKEEGLMGESPEAMHYDEDRIFYHLAFYIDTAKNAAVNGLESSSPSFDTQERLVKVEKLLIENGGRVARSISDPKLTHIIMDDEDSRRYVELTRKTAMPKRKHIVTPKWVEDCVDEETLLDEDLYKPK
What is the function of this protein?
Involved in ds DNA break repair.  Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining.
What are the official names of this protein?
DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SIM35_MOUSE
Sequence: MAGDDSISTLGMILGVGLSLLLVSILGYSLAKWYQRGYCWDGPNFVFNLYQIRNLKDLEVGPPFTISGHMSSPDGGYMKFSNDRV
What are the official names of this protein?
Small integral membrane protein 35.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SSRP_ECO45
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVLLRDGEAFLFGANITPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRVNREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDIKEREWQVDKARIMKNAHR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RRF2M_DROAN
Sequence: MLKYEFLHGLQKRSHYLRQLSGQFFSRSYSSKIRNIGILAHIDAGKTTTTERMLFYAGKTRTLGEVHRGNTVTDYLTQERERGITICSSAVTFAWNGHRINLLDTPGHIDFTMEVEQSLYAVDGVVVVLDGTAGVEAQTVTVWTQADKHKLPRLIFVNKMDRPDADFEKCIADLKEKLEAHPVCLQYPVKNEDGVLAINDVITLERLTWQQKDLGQKYIRMKLEPSDELRDLQEKRNELIDRLSGVDDELADVVISTESFDKVDNHLIERALRRATGQLKVVPVLLGSAYKNVGIQRLMDAVNSYLPAPEERNQIYDCFGSEVAGKVFKIVHDKQRGALTLVRILRGEIKKGMRLISARGQAEVVSKLYEPLADEYREVNAVQSGDVVICAGLKSTVTGDLLTSSQSTLKNAQKRLKQSLGTTESVIPELDDESEESEDMFGLDPQIPDAVYFCSIEPPSISSQTAMEQALRQLQREDPSLRVSYDSVTGQTVLGGMGELHMDIIKSRILSEYKIDVDLGPLQIAYKETIESPALTTLSVEKEIAGAKQNVSITLELVKDKSEIFSLDKSPENMPNLNTLRPRILQVLKKGAIGALERGPRVGGQVVDTQIRLHNATIGRGTADSFVMATAAQCVQKVLSTSGTRLLEPIMSLQIVAPSERISGIMADLSRRRAQINDVLPKGERNKMILVNAPLAELSGYSSALRTISSGTASMTMQPCGFSAMNSVDESQAERRAQGLE
What is the function of this protein?
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.  Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
What are the official names of this protein?
Ribosome-releasing factor 2, mitochondrial, RRF2mt, Elongation factor G 2, mitochondrial, EF-G2mt, mEF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GATB_AJECH
Sequence: MIRQFVSHRGIPCYRLAVRRVELTEPFHHPSPWPLGRKNWSTSDEAKSKRAAMRKGGAPPPEHEDWELTVGIEIHAQLDTDAKLFSSASAALDDVPNSNIALFDIALPGSQPLFQPSTLIPAIRAAIALNCDVQRVSRFDRKHYFYQDQPAGYQITQYYEPYAKNGSIWLGAHDGIAKEDGEGVQIGIKQIQMEQDTAKSQELPSSTYLLDFNRVSRPLIEIITLPQIHSATTAAACVRKIQAILQSVGAVTTGMEMGGLRADVNVSVRKRSEAAGDHQYDGVAGLGQRTEIKNLSSFKAVEYAIIAERDRQIAVLKAGGTIQGETRGWTLGSTETRKLRGKEGEVDYRYMPDPDLGPVIIGDDVISDLRRNIPGLPDELLQMLVQDPKYGLSTVDAKTLIELDDGQRLEYYQDAVEILTTLQPDLSADFSAGKVVGNWVLHELGGLLTKSSAHWDSQRVPAQSLAEIINLLSRKNITSSSAKSLLAMAFDGDKRSISQIVEDKNLLFQSLSRHEYLALAEEVMRQNPKMVSEIREKAQLGKMGWLVGQIKRIGDPNRVEAQKAEEILRELILK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial, Glu-AdT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TTL3A_DROME
Sequence: MQTRPSSEPHRSRDQVTDGDRNRDQPQKCASATLAKKPVTPPAAPPPTPSNRVVAPLTVPVIQLTPAQSDSPVKLARPATPKETAISVPDHSNKENQPARTPPPSKSCPLGAPTNYVARRTWITTERMNELRRKAQEAAKQNKIFTIRGCFNSVRNALLMRGWVEKLDVHRKVMPAGQMTYEDLTQRLPKRKAGETRRQYVQKCERNIMSRFLEHMPVDFLWTNRKEKCDYIDQAKNPGMTINKFHRAPFTSKEGLCSQLRDFHWFFEEGTAEMYFPRCYNVWSPEELGEFIENFKLTACVAFLRAMLCKYHKQGSDAVFSCSGKIPYSAIDFAYKRLVEYIDSCQHNDIDFEDPPKIWEHDWDAFLFQHQQLVNEDGRIQHDGGQRLEPMVKSCLSLVDKMKVHWPQYSLDGYQNMWIVKPANKCRGRGIILMDNLKKILGVVNLSIASKSRYVVQKYIERPLILFQTKFDIRQWFLITNTQPLVVWFYRESYLRFSSQEYSLSNHHESVHLTNYAIQKKYTNGKRDKRLPSENMWDCYSFQAYLRQIGKYNMWLERIFPGMRKAIVGCMLASQENMDRRPNTFELFGADFMICENFYPWLIEINSSPDLGATTSVTARMCPQCLEDVVKVVIDRRTDPKAELGNFELAYRQVVPPTPAYMGLNLFVKGKQVLQKANHGGGHGHYYYQQQRKERSLATSSVYRQRSAIIHPATSISRIHRAMPTFNATEYMEKYMVEPLSSSRSSLCSQLPQKSPSAAPALTATPSGATSSYILKQAGRSITQLLSATHKRNTGGSLSGEQVQSTALPPKRQRSCGPRLSSTNPVESTEKKFKILIKNYSSNGNENMQDARPEVANSATATAISERKWRSLRNIAATAGGSSNLAARSKGPPLIAPPSLPTRRLTRTKSEIDSTGMHAIGRTFGRKSNGPRLPISISVQALHRGEPIVAALKQATSELQLSQAQMMSPRTALANKLNGSTLMVPASALPVG
What is the function of this protein?
Polylycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin.  Involved both in the side-chain initiation and elongation steps of the polyglycylation reaction by adding a single glycine chain to generate monoglycine side chains and by elongating monoglycine side chains to polyglycine side chains.
What are the official names of this protein?
Tubulin glycylase 3A, dmTTLL3A.
Protein: HNF6_HUMAN
Sequence: MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVAHRGSHLPPAHPRSMGMASLLDGGSGGGDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPLSSSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGNSSSSSSTCTKA
What is the function of this protein?
Transcriptional activator.  Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR.  Important for liver genes transcription.
What are the official names of this protein?
Hepatocyte nuclear factor 6, HNF-6, One cut domain family member 1, One cut homeobox 1.
What is the protein family that this protein belongs to?
Belongs to the CUT homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECA_SINFN
Sequence: MVSLGGLARKLFGSANDRRVRGYQGRVDAINALEAEMKALSDEALAAKTVEFRQQLAEGKTLDDLLVPAFAVVREAARRVLGLRPFDVQLIGGMILHERSISEMKTGEGKTLVATLPVYLNALAGKGVHVVTVNDYLAQRDAGMMGRIYGFLGLTTGVIVHGLTDEQRRDAYACDVTYATNNELGFDYLRDNMKYERAQMVQRGHFFAIVDEVDSILVDEARTPLIISGPLDDRSDLYNTINDFIPLLSPEDYEIDEKQRSANFSEEGTEKLENLLRQAGLLKGESLYDIENVAIVHHVNNALKAHKLFTRDKDYIVRNDEIVIIDEFTGRMMPGRRYSEGQHQALEAKEKVQIQPENQTLASVTFQNYFRMYEKLAGMTGTAATEAEEFGNIYGLEVVEVPTNLPIKRADEDDEVYRTAGEKYKAIIDEIKAAHERGQPMLVGTTSIEKSELLADMLKKSGFSKFQVLNARYHEQEAFIVAQAGVPGAVTIATNMAGRGTDIQLGGNPDMRIQQELAEVEPGPEREAREKAIREEVQKLKEKALDAGGLYVLATERHESRRIDNQLRGRSGRQGDPGRSKFFLSIQDDLMRIFGSDRMDGMLQKLGLKEGEAIVHPWINKALERAQKKVEARNFDIRKNLLKYDDVLNDQRKVIFEQRLELMDAESVSDTVADMRNEVIEDIVSKRIPERAYAEQWDVTGLKADVQQYFNLDLPVPDWAAEEGIAEDDILERVTAAVDAAAAERAERFGPEIMQYVERSVVLQTLDHLWREHIVNLDHLRSVIGFRGYAQRDPLQEYKSEAFELFQALLVNLRQAVSAQLMRVELVRETPQEPQPLPPMQGHHIDPLTGEDDFAEAPLLAVAPADRNPAEPSSWGKVARNEPCPCGSGKKYKHCHGIYEA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ENO_STAAM
Sequence: MPIITDVYAREVLDSRGNPTVEVEVLTESGAFGRALVPSGASTGEHEAVELRDGDKSRYLGKGVTKAVENVNEIIAPEIIEGEFSVLDQVSIDKMMIALDGTPNKGKLGANAILGVSIAVARAAADLLGQPLYKYLGGFNGKQLPVPMMNIVNGGSHSDAPIAFQEFMILPVGATTFKESLRWGTEIFHNLKSILSKRGLETAVGDEGGFAPKFEGTEDAVETIIQAIEAAGYKPGEEVFLGFDCASSEFYENGVYDYSKFEGEHGAKRTAAEQVDYLEQLVDKYPIITIEDGMDENDWDGWKQLTERIGDRVQLVGDDLFVTNTEILAKGIENGIGNSILIKVNQIGTLTETFDAIEMAQKAGYTAVVSHRSGETEDTTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDELFETAKYDGIKSFYNLDK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: CDIB_ECOLX
Sequence: MRHRQDNLLANRTLLPGMASGQYVFRLCTFSPVVRYFSLLPCLCILSFSSPAAMLSPGDRSAIQQQQQQLLDENQRQRDALERSAPLTITPSPETSAGTEGPCFTVSSIVVSGATRLTSAETDRLVAPWVNQCLNITGLTAVTDAMTDSYIRRGYITSRAFLTEQDLSGGVLHITVMEGRLQQIRAEGADLPARTLKMVFPGMEGKVLNLRDIEQGMEQINRLRTEPVQIEISPGDREGWSVVTLTALPEWPVTGSVGIDNSGQKSTGTGQLNGVLSFNNPLGLADNWFVSGGRSSDFSVSHDARNFAAGVSLPYGYTLVDYTYSWSDYLSTIDNRGWRWRSTGDLQTHRLGLSHVLFRNGDMKTALTGGLQHRIIHNYLDDVLLQGSSRKLTSFSVGLNHTHKFLGGVGTLNPVFTRGMPWFGAESDHGKRGDLPVNQFRKWSVSASFQRPVTDRVWWLTSAYAQWSPDRLHGVEQLSLGGESSVRGFKDQYISGNNGGYLRNELSWSLFSLPYVGTVRAVAALDGGWLHSDSDDPYSSGTLWGAAAGLSTTSGHVSGSFTAGLPLVYPDWLAPDHLTVYWRVAVAF
What is the function of this protein?
Probable member of a two partner secretion pathway (TPS) in which it mediates the secretion of CdiA.
What are the official names of this protein?
Outer membrane transporter CdiB.
What is the protein family that this protein belongs to?
Belongs to the TPS (TC 1.B.20) family.
What are the subcellular locations of this protein?
Cell outer membrane.