PharMolix/UniProtQA huggingface dataset:
Protein: CRLD1_MOUSE
Sequence: MMCKAQEWLRVTALLFVARAVPAMVVPNATLLEKLLEKYMDEDGEWWTAKQRGKRAITDNDMQSILDLHNKLRSQVYPTASNMEYMTWDVELERSAESWAEMCLWEHGPASLLPSIGQNLGAHWGRYRPPTFHVQAWYDEVRDFSYPYENECDPYCPFRCSGPVCTHYTQVVWATSSRIGCAVNLCHNMNIWGQIWPKAVYLVCNYSPKGNWWGHAPYKHGRPCSACPPSFGGGCRENLCYKEGSDRYYTPREEETNEIERQQSQVHDTHVRTRSDDSDRNDVISTQQMSQIVSCEVRLRDQCKGTTCNRYECPAGCLDSKAKVIGSVHYEMQSSICRAAIHYGIIDNEGGWVDVTRQGRKHYFIKSNRNGIQTIGKYHSANSFTVSKVTVQAVTCETTVEQLCPFHKPASHCPRVYCPRNCMQSNPHYARVIGTRIYSDLSSICRAAVHAGVVRNHGGYVDVMPVDKRKMYTASFQNGIFSESLQNPTGGKAFRVFAVV
What are the official names of this protein?
Cysteine-rich secretory protein LCCL domain-containing 1, CocoaCrisp.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOB_FRAP2
Sequence: MGIGNENKGFITASADALINWVRTGSLWPVTTGLACCAVEMMHAGAARYDLDRFGIVFRPSPRQSDVLIVAGTLCNKMAPALRQVYDQMPDPKWVISMGSCANGGGYYHYSYSVVRGCDRIIPVDIYVPGCPPTAEALVYGIIQLQNKIIRKDTIARK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HSCB_BORPE
Sequence: MAADDHFSLFGLPTRFALDPVQLEQAWRAVAARVHPDRYATASAAERRVAMQWAARANEAYRQLRDPMLRARYLCEQAGVDLQTESNTAMDPAFLMQQMEWREMLDDARRDPAAFAALRAELEQARLRMQQTLSELIDERGDYQQAGTKVREWMFVEKLAQELSAAQPMQ
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: KYNU1_ASPNC
Sequence: MSSQLGHESSVSSPLSYKTDSNAFTREYAESLDAQDPLRDFRKEFIIPSKVDLKRKTLAIDDSSKDESDPRCIYLCGNSLGVQPRNARKYIDYYLRTWAIKGVTGHFLPHEDQLLPPFVDVDDAGAKLMAPIVGALESEVAVMGTLTANLHFLMASFYRPTQERYKIILEGKAFPSDHYAIESQIRHHNLRPEDAMVLIEPEDRLKPILRTEQILRVIDEHASSTALVLLSGIQFYTGQYFDIEKITAHAQSKGILVGWDCAHAAGNVDLRLHDWNVDFAAWCNYKYLNSGPGGMAALFVHERHGRVDMDKVGSDEEPFRPRLSGWWGGDKKTRFLMNNNFLPQTGAAGFQLSNPSVLDMNAVVASLELFNRTSMAEIRQKSLNATGYLEHLLLNYPADFSTGKRPFSIITPSNPAERGAQLSLLLEPGLLDSVLETLEEHGVVVDERKPDVIRVAPAPLYNTYTEYPTYRT
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase 1, Biosynthesis of nicotinic acid protein 5-1, L-kynurenine hydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_STAAM
Sequence: MSERNDRKVYVGKVVSDKMDKTITVLVETYKTHKLYGKRVKYSKKYKTHDENNSAKLGDIVKIQETRPLSATKRFRIVEIVEESVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: DAPB_STRP4
Sequence: MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQDIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELKEFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKTAELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGLTLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIT_SALDC
Sequence: MTSTVEFINRWQRIALLSQSLLELAQRGEWDLLLQQEVSYLQSIETVMEKQTPPGITRSIQDMVAGYIKQTLDNEQLLKGLLQQRLDELSSLIGQSTRQKSLNNAYGRLSGMLLVPDAPGAS
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PYRDB_BACCZ
Sequence: MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRVAETPGGMLNAIGLQNPGLEKVMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPNVHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEVPVYVKLSPNVANIVEIAKAIENAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPIIGMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGRSWKQTCHSR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYCN_YEREN
Sequence: MSWIEPIISHFCQDLGVPTSSPLSPLIQLEMAQSGTLQLEQHGATLTLWLARSLAWHQCEDAMVKALTLTAAQKSGALPLRAGWLGENQLVLFVSLDERSLTLPLLHQAFEQLLRLQQEVLAP
What is the function of this protein?
Functions as a specific chaperone for YopN.  It could facilitate the secretion and the subsequent translocation of YopN.
What are the official names of this protein?
Chaperone protein SycN.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein. Note=Not exported across the inner membrane.
Protein: L_ABLVH
Sequence: MIDPGEVYDDPIDPVEPEPELKNNTVIPNILRNSDYNLNSPLIEDSARLMLEWLTTGNRPGRLTLTDNCIRSYKTLKCYFRKVDVGSLKVGGLAAQAMISLWLHGEHSESNRSRKCLSDLTQFYQKSSPIEKLLNYTLGNRGLRIPPEGVLFCLKKVDYDRAFGRYLANIYASYLFFHVIILYMNALDWDEEKTILALWKDLSSVDIKKDQVKFRDPIWGSLIVTKDFVYSQNANCLFDRNYTLMLKDLFLSRFNSLLILLSPPEPRYSDDLISQLCQLYIAGDNVLSMCGNSGYDVIKMLEPYVVNSLVQRAEGFRPLIHSLGDFPLFIRDKVGQLEGTFGPSARKFFQVLDQFDNIHDLVFVYGCYRHWGHPYIDYRKGLSKLYDQVHIKKVIDGTYQECLASDLAKRVLRWGFDKYSKWYLDPKLLAQDHPLTPYIRTQTWPPKHIVDLVGNTWHRLPITQIFEIPESMDPSEILDDKSHSLTRTKLASWLAENRGGPVPSEKVIITALSKPPVNPREFLKSIDLGGLPDDDLIIGLKPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDRVTGQGLQDYSRVTYAFHLDYEKWNNHQRLESTKDVFSVLDQVFGLKKVFSRTHEFFQKSWVYYSDRSDLIGLWEDQIYCLDMSDGPTCWNGQDGGLEGLRQKGWSLVSLLMIDRESQTRNTRTKILAQGDNQVLCPTYMLSSGLSQEGLLYELESISRNALSIYRAIEDGASKLGLIIKKEETMCSYDFLIYGKTPLFRGNILVPESKRWARVSCISNDQIVNLANIMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILSADGDDFLLAMSRIIYLDPSLGGVSGMSLGRFHIRQFSDPVSEGLSFWKEIWSSSSEPWIHSLCQEAGNPDLGDRSLESFTRLLEDPTTLNIRGGASPTILLKDAIRKALYDEVDKVENSEFREAILLSKTHRDNFILFLKSIEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRRSLSRSLEESFYNSEIHGINRMTQVPQRIGRVWSCSSERADLLREISWGRKVVGTTVPHPSEMLTLLPKSSISCVCGPTGSENPRVSVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRALSLKESINWFIARDSNLAQTLIKNIISLTGPQFPLEEAPVFKRTGSALHRFKSARYSEGGYSSICPNLLSHISVSTDTMSDLTQDGRNFDFMFQPLMLYAQTWTSELVQKDIRLKDSTFHWHLRCQKCIRSIDDITLDTSQVFEFPDVSKRISRMVSGAVPQFQKLPEVYLKPGHFDSLCGKDKSRHIGSAQGLLYSILVATHDPGYNDGTIFPVNIYSKISPKDYLRGLARGVLIGSSICFLTRMTNININRPLELISGVISYILLRLDNHPSLYVMLRESSLRSEIFSIPQKIPAAYPTTMKEGNRSVLCYLQHVLRYERDIITSSPENDWLWIFSDFRSTKMTYLTLITYQSHILLQRIERSLSKKMRADLRQLSSLMRQVLGGHGEDSLDSGEDIQRLLRDALQRTRWVDQEVRHAAKTMTGDHSPSKKTSRKAGCSEWICSAQQVAISTSSNPAPVSEMDIRTLSRKLQNPLISGLRVVQWATGAHYKLKPILDDLNAYPSFCLVVGDGSGGISRTVLNMFPDAKLVFNSLLEVSDLMASGTHPLPPSAIMSGGDDIVSRVVDFESIWEKPSDLRNLSTWRYFQSVQSKLNMSYDLIICDAEVTDIISVNKITLLMSDFVLSIDGPLDLIFKSYGTMLVNPDYKAIQHLSRAFPKATGYITQLTSSFSSELYLRFSKRGKFFRDVEYLTSSTLREMSLVLFNCSSPKSELQRARSLNYQDLIRGFPEEIVSNPYNEMIITLIDSEVESFLVHKMVDDLELQRGTLSKMSIIIAIVIVYSNRVFNVSKPLSDPVFYPPSDPKILRHFNICCSTMLYLSTILGDVPNFARLHELYNSPITYYFKKQIIRGSIYLSWSWSDDTSVFKRVSCNSNLSLSSHWIRLIYKIIKTTRFTGSHVDLSKEVEKHLKGYNRWITFNDVRSRSSLLDYSCL
What is the function of this protein?
RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA.  The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N).  The replicase mode is dependent on intracellular N protein concentration.  In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
What are the official names of this protein?
Large structural protein, Protein L, Replicase, Transcriptase.
What is the protein family that this protein belongs to?
Belongs to the rhabdoviruses protein L family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=L and P are packaged asymmetrically towards the blunt end of the virus.
Protein: L_RABVS
Sequence: MLDPGEVYDDPIDPIELEAEPRGTPIVPNILRNSDYNLNSPLIEDPARLMLEWLKTGNRPYRMTLTDNCSRSFRVLKDYFKKVDLGSLKVGGMAAQSMISLWLYGAHSESNRSRRCITDLAHFYSKSSPIEKLLNLTLGNRGLRIPPEGVLSCLERVDYDNAFGRYLANTYSSYLFFHVITLYMNALDWDEEKTILALWKDLTSVDIGKDLVKFKDQIWGLLIVTKDFVYSQSSNCLFDRNYTLMLKDLFLSRFNSLMVLLSPPEPRYSDDLISQLCQLYIAGDQVLSMCGNSGYEVIKILEPYVVNSLVQRAEKFRPLIHSLGDFPVFIKDKVSQLEETFGPCARRFFRALDQFDNIHDLVFVFGCYRHWGHPYIDYRKGLSKLYDQVHLKKMIDKSYQECLASDLARRILRWGFDKYSKWYLDSRFLARDHPLTPYIKTQTWPPKHIVDLVGDTWHKLPITQIFEIPESMDPSEILDDKSHSFTRTRLASWLSENRGGPVPSEKVIITALSKPPVNPREFLRSIDLGGLPDEDLIIGLKPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDRVTGQGLLDYSRVTYAFHLDYEKWNNHQRLESTEDVFSVLDQVFGLKRVFSRTHEFFQKAWIYYSDRSDLIGLREDQIYCLDASNGPTCWNGQDGGLEGLRQKGWSLVSLLMIDRESQIRNTRTKILAQGDNQVLCPTYMLSPGLSQEGLLYELERISRNALSIYRAVEEGASKLGLIIKKEETMCSYDFLIYGKTPLFRGNILVPESKRWARVSCVSNDQIVNLANIMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILSAEGESFLLAMSRIIYLDPSLGGISGMSLGRFHIRQFSDPVSEGLSFWREIWLSSQESWIHALCQEAGNPDLGERTLESFTRLLEDPTTLNIRGGASPTILLKDAIRKALYDEVDKVENSEFREAILLSKTHRDNFILFLISVEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRKSLSKTLEESFYNSEIHGISRMTQTPQRVGGVWPCSSERADLLREISWGRKVVGTTVPHPSEMLGLLPKSSISCTCGATGGGNPRVSVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRALSLKESINWFITRDSNLAQALIRNIMSLTGPDFPLEEAPVFKRTGSALHRFKSARYSEGGYSSVCPNLLSHISVSTDTMSDLTQDGKNYDFMFQPLMLYAQTWTSELVQRDTRLRDSTFHWHLRCNRCVRPIDDVTLETSQIFEFPDVSKRISRMVSGAVPHFQRLPDIRLRPGDFESLSGREKSHHIGSAQGLLYSILVAIHDSGYNDGTIFPVNIYGKVSPRDYLRGLARGVLIGSSICFLTRMTNININRPLELVSGVISYILLRLDNHPSLYIMLREPSLRGEIFSIPQKIPAAYPTTMKEGNRSILCYLQHVLRYEREIITASPENDWLWIFSDFRSAKMTYLSLITYQSHLLLQRVERNLSKSMRDNLRQLSSLMRQVLGGHGEDTLESDDNIQRLLKDSLRRTRWVDQEVRHAARTMTGDYSPNKKVSRKVGCSEWVCSAQQVAVSTSANPAPVSELDIRALSKRFQNPLISGLRVVQWATGAHYKLKPILDDLNVFPSLCLVVGDGSGGISRAVLNMFPDAKLVFNSLLEVNDLMASGTHPLPPSAIMRGGNDIVSRVIDLDSIWEKPSDLRNLATWKYFQSVQKQVNMSYDLIICDAEVTDIASINRITLLMSDFALSIDGPLYLVFKTYGTMLVNPNYKAIQHLSRAFPSVTGFITQVTSSFSSELYLRFSKRGKFFRDAEYLTSSTLREMSLVLFNCSSPKSEMQRARSLNYQDLVRGFPEEIISNPYNEMIITLIDSDVESFLVHKMVDDLELQRGTLSKVAIIIAIMIVFSNRVFNVSKPLTDPSFYPPSDPKILRHFNICCSTMMYLSTALGDVPSFARLHDLYNRPITYYFRKQVIRGNVYLSWSWSNDTSVFKRVACNSSLSLSSHWIRLIYKIVKTTRLVGSIKDLSREVERHLHRYNRWITLEDIRSRSSLLDYSCL
What is the function of this protein?
RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA.  The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N).  The replicase mode is dependent on intracellular N protein concentration.  In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
What are the official names of this protein?
Large structural protein, Protein L, Replicase, Transcriptase.
What is the protein family that this protein belongs to?
Belongs to the rhabdoviruses protein L family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=L and P are packaged asymmetrically towards the blunt end of the virus.
Protein: A1X1_LOXRE
Sequence: ANKRPVWIMGHMVNAVYQIDEFVNLGANSIDTDVS
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LrSicTox-alphaI-1, Mammalian toxin, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y627_BACTN
Sequence: MGRAFEYRKAAKLKRWGHMAKTFTRLGKQIAIAVKAGGPEPENNPTLRSVIATCKRENMPKDNIERAIKNAMGKDQSDYKSMTYEGYGPHGIAVFVDTLTDNTTRTVADVRSVFNKFGGNLGTMGSLAFLFDHKCMFTFKIKDGMDMEELILDLIDYDVEDEYEQDDEEGTITIYGDPKSYAAIQKHLEECGFEDVGGDFTYIPNDLKEVTPEQRETLDKMIERLEEFDDVQTVYTNMKPEEGGNEE
What are the official names of this protein?
Probable transcriptional regulatory protein BT_0627.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP4M1_BOVIN
Sequence: MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHDDRHFIHIRHSGLYLVATTSENISPFSLLELLSRLATLLGDYCGSLGEATISRNVALVYELLDEVLDYGYVQTTSTEVLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVYLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLPPKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELGEGALRWDLPRVQGGSQLSGLFQMDVPGLPGPPGQGPSASAPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
What is the function of this protein?
Component of the adaptor protein complex 4 (AP-4).  Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection.  They control the vesicular transport of proteins in different trafficking pathways.  AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.  It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons.  Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos.  The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
What are the official names of this protein?
AP-4 complex subunit mu-1, AP-4 adaptor complex mu subunit, Adaptor-related protein complex 4 subunit mu-1, Mu subunit of AP-4, Mu-adaptin-related protein 2, mu-ARP2, Mu4-adaptin, mu4.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome. Note=Found in soma and dendritic shafts of neuronal cells.
Protein: TLR4_GORGO
Sequence: MMSASRLAGTLIPAMAFLSCVRPESWEPCVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEYLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMTFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVRRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLRVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENVYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
What is the function of this protein?
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS).  Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate.  In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42.  In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36.  This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.  Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).  Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (By similarity).
What are the official names of this protein?
Toll-like receptor 4.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Early endosome. Cell projection, ruffle. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation.
Protein: SERB_ECO57
Sequence: MPNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLGAAMVIVAAWCVEDYQVIRLAGSLTARATRLAHEAQLDVAPLGKIPHLRTPGLLVMDMDSTAIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRSRVATLKGADANILQQVRENLPLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVIGDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKAEVTIRHADLMGVFCILSGSLNQK
What is the function of this protein?
Catalyzes the dephosphorylation of phosphoserine (P-Ser).
What are the official names of this protein?
Phosphoserine phosphatase, PSP, PSPase, O-phosphoserine phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. SerB family.
Protein: ISPF_ECO8A
Sequence: MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: WFDC1_CHICK
Sequence: MDSRMLSDQRFCRRIFAAALCVLVLLADSGCARNLWKRALHLKMTEKYDDYEYPLHSHSAHYQKNDRCPPPPQTLPDRACEVPSCRSDSECERHKRCCYNGCIYACLESVQPPPVLDWLVQPKPRWLGGNGWLLDGPEEVLQAEACSTTEDGDEPLHCPTGYECHIINPGNTAEGIPNRGQCIKLRGNPDGRNLRHKYYKEYFGSNSNNVVGYVKNQQKHLG
What is the function of this protein?
Has growth inhibitory activity.
What are the official names of this protein?
WAP four-disulfide core domain protein 1, Protein ps20.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPX_RICRS
Sequence: MVVEADKKALICSFCSKKQHEVKKLIAGPAVFICDECIDLCTDIMKEENKVALKQITSSIPTPQKICGILNDYVVGQDQAKKILAVAVYNHYKRLEYIQSGNNDVELNKSNILLIGPTGSGKTVLAQTLAKILDVPFTMADATSLTEAGYVGEDVENILLRLLIASEFNIAKAQKGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQDFVQLDTSNILFICGGAFMGIDSIITSRTNHSSIGFAANVNIDKEKNNSEILKSLEIEDLTKFGLIPEFIGRLPIVTTLDELDKEALITILTKPKNAIVKQYQKQFELDDAELVIDDSALETIAEKALAKKTGARGLRSILEHLLLDSMYKVAELKKQRVTITKEVVNGLVEPIMTSLISTKSNKKQPIIADIPA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: PYRH_ARTS2
Sequence: METVNNSVQSEKSRRRVLLKLSGEVFGGGKLGVDPDTVRGVAKQIAAAVPDVEVAIVVGGGNFFRGAELSQSGMDRSRADYMGMLGTVMNCLALQDFLEQAGVETRVQSAITMGQVAEAYIPRRAIRHMEKGRVVIFGAGAGLPYFSTDTVAAQRALEVHADVVLMAKSGVDGVYTADPKKDPEAEKLDHLSYDEALRRDIRVMDQTAMTMCKDNNLTMVVFGMEGEGNVTRAIRGEQLGTVVTP
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_GEOMG
Sequence: MSKTHVYELAKKMGVENKELMARLKSLGIEVKSHLSVLEDEDVQKVTAPPTPPKGVQQQEEVRVTTTVIRRRPKAVAQPPEEVAPAAVESAVIEEAPAPRVEAVPEEPKASPAFAETVPAVEEPKGVEPKIGVPKVETPVASESKAEEPRVTAPPAQPKPVAAEEEKPTMNRARILGRVELPGLTTASKPVPKPAERREVVIPPKRKMEERAVTPQPAAPVADDRKKKAKTFTEPETPAGGAPGAKKGAPGGKKKEAFKKAELLEKRERIFEPGPKTGKGRRRERESVTFGKKTEITVPKAIKRIIKISESITVGELAKRMGVKATDLIRVLMKMGMMATINHPLDVDTATLIAAEFSYEIENVAIDTDEMLESAPDTPESLKKRPPVVTIMGHVDHGKTSLLDAIREANVIAGEAGGITQHIGAYDVELNGRKITFLDTPGHEAFTAMRARGAKVTDIVILVVAADDGVMPQTREAINHSKAAGVPIIIAINKIDKPEAKPERVKQELMEFGLVSEEWGGETIFVEVSAKKRINLPELLEMVLLQADVMDLKANPDKEARGTIVEAKLDRGRGPVATVLVQEGTLKVGDYFVAGVHSGRVRAMQNDRGDKVLAAGPSMPVEVIGFTGVPDAGDVFISLSDEKKAKEIASHRQQKLRETELAKHSKMSLEQLYDKIQKGEVKDLNAIVKADVQGSVEAVSDSLRKLSTDAVRLNVIHSSVGAITETDVNLASASNAIILGFNVRPEPKASAMAEKEGVDVRLYNIIYDAVEDIKKAMEGLLEPTLREKYLGRAEIREVFSVPKVGNVGGCYIQDGKVLRNASVRLLRDNVVVYEGKMSSLRRFKDDVKEVATGYECGIGLENYNDIKVGDIIEAFEIEKIATKL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.