PharMolix/UniProtQA huggingface dataset:
Protein: CYSC_SALG2
Sequence: MALHDENVVWHSHPVTVAAREQLHGHRGVVLWFTGLSGSGKSTVAGALEEALHQRGVSTYLLDGDNVRYGLCRDLGFSDADRQENIRRVGEVASLMADAGLIVLTAFISPHRAERQLVKERVGHDRFIEIYVNTPLAICEQRDPKGLYKKARAGELRNFTGIDAIYEAPDSPQVHLNGEQLVTNLVSQLLDLLRRRDIIRS
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: GPMA_STRP1
Sequence: MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIEFDLAFTSVLTRAIKTTNLALENAGQLWVPTEKSWRLNERHYGALTGKNKAEAAEQFGDEQVHIWRRSYDVLPPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAMPYWEEKIAPALLDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDEKLNIVKEYYLGGE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: PLSX_ANAMF
Sequence: MVRDSGACVSVALDAMGADLGPEVAIKGADLVLSGAVPCKHKVHLSIYGKESAVLPVLGKYKLVEKNSVFIDTPDAVLCDDRPSFALRHRRKSSMWCAIEDVKKGVVASAVSAGNTGALMAISRYLLGTLQGIDRPAIATVLPSRKGSFVALDLGANAECAPGLLFQFAIMGRAFARAVLGVEHPKVGLLNIGAEDTKGTYNIQEAFALMRDAKQDINFYGYVEAKEAFDGVADVVVADGFSGNIMLKTCEAVAGLTLHILKKEICSSLMGRAAMRILRSCYFKRTSGSALDVRSYNGAVLLGLNGIVVKSHGSADATAFAHAIKEAVCVISQGDMAKEMISEVSNG
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: DXR_HELPG
Sequence: MVVLGSTGSIGKNALKIAKKFGVEIEALSCGKNIALINEQIQVFKPKKVAVLDPNDLNNLEPLGAEVFVGLEGIDAMIEECASNLVLNAIVGVAGLRASFKSLQRNKKLALANKESLVSAGHLLDISQITPIDSEHFGLWALLQNKTLKPKSLIISASGGAFRDTPLELIAIQNAQNALKHPNWSMGSKITIDSASMVNKLFEILETYWLFGASLKIDALIERSSIVHALVEFEDNSVIAHLASADMKLPISYAINPKLASLNASIKPLDLYALSAIKFEPISMERYTLWRYKDLLLENPKLGVVLNASNEVAMKKFLNQEIAFGGFIQIISQALELYAKKSFKFSTLDEVLELDKEVRDRFKNYR
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: ASPD_ACIBY
Sequence: MKKLMMIGFGAMAAEVYAHLPQDLQLKWIVVPSRSIEKVQSQVSSDIQVISDIEQCDGTPDYVIEVAGQAAVKEHAQKVLAKGWTIGLISVGTLADSEFLVQLKQTAEKNDAHLHLLAGAIAGIDGISAAKEGGLQKVTYKGCKSPKSWKGSYAEQLVDLDHVSEPTVFFTGTAREAAMKFPANANVAATIALAGLGMDETMVELTVDPTINKNKHTIVAEGGFGQMTIELVGVPLPSNPKTSTLAALSVIRACRNSVEAIQI
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
What are the official names of this protein?
L-aspartate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: MRAY_MYCBT
Sequence: MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHTKRGTPSMGGVAILAGIWAGYLGAHLAGLAFDGEGIGASGLLVLGLATALGGVGFIDDLIKIRRSRNLGLNKTAKTVGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVTLAPVLFVLFCVVIVSAWSNAVNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLALIAAATAGACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEILAVVLGALFVAEITSVVLQILTFRTTGRRMFRMAPFHHHFELVGWAETTVIIRFWLLTAITCGLGVALFYGEWLAAVGA
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KLF7_MOUSE
Sequence: MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLHASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKASLSSVKVGGVAAAAAVTPAGAVKSGQSDSEQGGGGADTCPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI
What is the function of this protein?
Transcriptional factor (PubMed:11245580).  Plays a critical role in neuronal morphogenesis (PubMed:11336497, PubMed:15964824).  Represses the corneal epithelium differentiation (By similarity).  Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells.  Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (By similarity).
What are the official names of this protein?
Krueppel-like factor 7.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZIPA_YERP3
Sequence: MQDLRLILIVVGAIAIIALLLHGLWTSRKERSSLFRDRPVKRTKQERVETPIESLDEGVGEVRVRTSHPQEKPSFNHLDDDDDEVPVIQHAETKSAQVKTASRQAPFASVQTDYDDPLLGGLSAEQPPHDLSRDPLLGKADESYSQPQHAEPPHVEKPAHQVAPQQHVESQQEPVAPAPEAKPQKLKETVLVLHVAAHHGGVIGGEVLLQSVLQSGFQFGEMGIFHRHLSPAGSGPVLFSLANMVKPGSFDPDTMSDFSTPGVSMFMMVPSYGDANQNFKLMLQSAQRIADDVGGVVLDDERRMMTPQKLESYKARIREVLDANTIA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: Y215_METTH
Sequence: MMYKVRNMRETEVVISDKTANPAPLGLLGFGITTILLNLHNAGLFPINSMILAMGFAYGGIAQILASVMEYRKGNTFGTVAFGSYGLFWWSLVLLLVIPNLKFLETSGTAAASADPVAMASYLFMWGLFTLLMFIATLKLKRGIQVIFISLAVLFFLLTAGEITGSALITAVAGYEGIFTGAAAMYVGLAEVINETHGRDILPT
What are the official names of this protein?
Uncharacterized protein MTH_215.
What is the protein family that this protein belongs to?
Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GEMI2_MOUSE
Sequence: MAWVPAESAVEELMPRLLPVEPCDLTEGFDPSVPPRTPQEYLRRVQIEAAQCPDVVVAQIDPKKLKRKQSVNISLSGCQPAPEGYSPTLQWQQQQVAHFSTVRQSVHKHRNHWKSQQLDSNVAMPKSEDEEGWKKFCLGERLCAEGATGPSTEESPGIDYVQVGFPPLLSIVSRMNQTTITSVLEYLSNWFGERDFTPELGRWFYALLACLEKPLLPEAHSLIRQLARRCSEVRLLVGSKDDERVPALNLLICLVSRYFDQRDLADEPS
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity).  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity).  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity).  Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity).  Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity).
What are the official names of this protein?
Gem-associated protein 2, Gemin-2, Component of gems 2, Survival of motor neuron protein-interacting protein 1, SMN-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the gemin-2 family.
What are the subcellular locations of this protein?
Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm (By similarity).
Protein: PHNC2_PSEU2
Sequence: MNEAIHVQGLNKTFSHKSALIDLALSIQPGEMVALIGASGSGKSTLLRHLAGLACCDRSNGGQVQVLGREVQSSGRLNSQVRRLRADIGYIFQQFNLVNRLSVLDNVLLGCLGRMPRWRGSLALFNNEEKQRAMVALERVGLADLAAQRASTLSGGQQQRVAIARALTQRAEVILADEPIASLDPESARRVMEILADINRRDGKTVVVTLHQVDYAVRYCPRAVALKSGRIHFDGQAQDLSKQFLNDLYGADADASLMITERSQRVRQKARLTLAKV
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: WNT2_DANRE
Sequence: MNFLPNGICFYLSVAICWFSSRVDASWWYMGTLGSQVMCDNIPGLINKQRQLCRQHPKVMQAIGAGIKNWIGECQHQFRTHRWNCNTMAREHNLFGRLLHRSSREAAFVYAISSAGMVYTLTRACSQGELENCSCDPGKKGSSRDAKGAFDWGGCSDHVDHAIKFTQVFIDAKERKERDARALMNLHNNRAGRKAVKRFMNLECKCHGVSGSCNVRTCWLAMADFRQTGDYLRKKYNNAIQVVMNQYGTGFTSAYRMLKRPNKNDLVYFEDSPDYCIWDHESGSVGTGGRVCNRTSRGTDSCEVMCCGRGYDTSRVSRTTKCECKFQWCCAVHCRDCQEEVDVHTCKTQS
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity).
What are the official names of this protein?
Protein Wnt-2.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: DUS1L_RAT
Sequence: MPKLQGFEFWSRALGGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANYRKENLYCDVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGRYGAFLQEEWDLLQRMILLAHERLSVPVTCKIRVFPEIDKTVRYAQMLEKAGCQLLTVHGRTKEQKGPMAGTASWEHIKAVRKAVGIPVFANGNIRCLQDVERCIQDTGVQGVMSAEGNLHNPALFEGRSPAVWELADEYLDIVRQHPCPLSYVRAHLFKLWHHTLQVHQQLREELAKVKTLEGVAAVSQALKLRCQEDMARQQEGVRPADNLPAFHWICQPYIRPGPKEGSKENSSGRSKRALEEEEGSMEGLSKNKLKKQLRNPHKTFDPSLKPKYAKCDQCGNPKGNRCVFNLCRGCCKKRAFRETADCPGHDCFLRPN
What is the function of this protein?
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
What are the official names of this protein?
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like, Liver regeneration-related protein LRRG08/LRRG09, tRNA-dihydrouridine synthase 1-like.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus1 subfamily.
Protein: TRL12_ARATH
Sequence: MDAISSLGTNCVLSGVSPFSQENQSKSKLSPFMSLDLKEHPMASADFTNQTLTAFSSSSASPFQAKTSSIGMSRGMRWWEKSTNHNMLEIQSANHLVDSLLNAGDRLVVLDFYSPGCGGCKSLHPKICQLAETNPNVMFLKVNQEELRTMCHGLNVHVLPFFKFYRGAEGKVCSFSCTIATINKFKKALDKHGSERCSLGDAKGLDEKELAALASVGELKMNSLTMHQASNIGYKTEEQYQTMVL
What is the function of this protein?
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
What are the official names of this protein?
Thioredoxin-like 1-2, chloroplastic, Atypical cysteine/histidine-rich thioredoxin 5, AtACHT5, Lilium-type thioredoxin 1-2.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TIG_LACAC
Sequence: MSVKWEKTGKTTGELTFDISKDEIKLGLDQAFKRIKKNLRVPGFRKGHVSRVIFDQYYGEEALYEDALNIVLPNAYAAAVKEAGINAVGQPQIVPVSMDKDKDWTMKATVTVQPEVELGEYKGIEVPKQNTRVYQKDIDAELDKRREQSAELVLKKGKAENGDTVTIDYKGTIDGKEFDGGSAENYSLELGSGTFIPGFEDQLVGHEAGDDVDVVVTFPKDYGAKDLAGKEAHFATKIHEVKSKQLPELDDEFAKDVDDSVDTLDELKEKIKKDLKDQKEQVANDAIQEAAIEGAVKNATIDEIPDAMIQEDVDTQLNQYLGNMQRQGIDPQTYYKLTNTTEDQLRSQFAKNAAERVKTNLVLEAIVAAEDLKATKEEIDKEIKDLAAEYNMDEKVVRNTLSDDMLGHDITVRKAMDLITDNAKQVAKSKLEAKDSDDKESK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: TRUA_ACTPJ
Sequence: MKIALGIEYDGSRYFGWQRQDEVESVQQKLEEALSIVANAPIEVFCAGRTDSGVHGTGQVVHFETQAIRPLQSWCFGTNANLPDDIAVKWAVEVSEDFHARFSATARRYRYIIFNNKLRSAILPKGVSHYHYELDHQKMHEAGQFLLGENDFSSFRAAKCQSHTPWRNVHYLNVSRLGNYIVVDIQANAFVHHMVRNIVGSLIEVGQGRQPVEWIQWLLAQRDRTLAAPTAKAEGLYLVDVHYPERFGIPKTALGPLFLADS
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: COXX_RICAH
Sequence: MSSLVTQIDLDKINHSQSTVKDYILLMKPRVMSLVMFTGFVGMWLAPYSVHPFIAVIVLACISLGAGSAGAINMWYDRDIDSLMKRTQKRPLVRGAIEPDEALSFGLITGFFAVFFMALCVNLLASFLLLFTIFYYICIYTIWLKRRSIQNIVIGGVSGALPPVIGYAAVSNTISLESIILFLIIFIWTPPHSWALALFCNDDYKNCKVPMMPTVKGILYTKEQILIYSILLFLVSLMPFFIGMNNFIYLIIAGMLGLVFLYYSGSLFYDTPDNKQAKRLFAYSIFYLFFIFLLLSSTSTISNIS
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MU147_SCHPO
Sequence: MLAQNSREVLDKDLESHIPGAYSPAPPSSSLPTQNESNLQQSEKPLKHFENKKFKGEDVFAHSISKPFDGQNDEEKPSLYSHLTNELYETHDSSDYFGTYMEREESGHDEEEADKDASFTGYYNSRNNDEEGSELADSQMLPMTESFADIEDIHHHQHEDEFSSSNKDKGFTYEKPVTELPPKRPPYHYESSSTSISFVNGGPNFRKVKSGLLKPDADAASNLSTTSLVNQEYVMKQVTPNEYSMEYLRESFPQTPMGTEASGYSFDRTPHKSDIQASDRLNALNEKLLQGIQQSHQPYHYTNVKDSQGSHQTKVTIEENMEAPSHQAANRTTLTDSPLGIVEDETTILTDLEPSGPGLQKRASETSMSTNVSLPYYQNGRRVRNILTPYPTVSLASTMTSETEDVSEERI
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 147 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRPD_RUMCH
Sequence: MIQEAIYQVINKQDLDLDKTIQVMEEIMEGRATNAQIGSFLTAMRMKGETIDEITACATVMRQKCKRIHPEKDVLDIVGTGGDEANTFNISTVSSFVVSAGGVPVAKHGGRSVSSKCGSADLLEALGINIALSAEQSAEILQKIGMCFMFAPTYHASMKYAAPVRKELSVRTIFNILGPLANPAGANMQLLGVYDENLVEPLARVLLNLGVKRAMVVHGHDGLDEVTLCNTTTICEVSNGNINSFFLSPEQLGFSRCLLKELVGGDPKKNASIALDILNGSKGPKRDIVVLNSALCLYMSYNQITLRDCVKMAEQLIDSGAAKAQLNKFIELSNSFNQEVK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: SYA_SULAC
Sequence: MVKANENEYRLNFFLSRGYERKICRSCSTPFWTLDKSKENCSDVPCTDYYFFDIKIKSPPLTVRESREKFLRFFEKRGHTIVPPKPVVAKWRDDLYLTIASIVDFQPFVTSGLAKPPANPLVVSQPCIRLEDVDNVGITFGRHLTTFEMAAHHAFNYPDKQIYWKDETVAFAKEFFTEELGIPEDQLNFKESWWEGGGNAGPCFEVTVGGLELATLVFMQYEIRGQDYVPLKLKIVDTGYGVERIAWFTQRTPTAFHAIYGNLVSSFYKKIGVGEVNNELLKAAAIYAGRIDPDIKETITAHREHLAKQLGLDLKYVNEELTRAARVFQVLDHTKTIALMLADGLVPSNSGEGYLGRLLIRRALRVLRLLGSDVKLHELIKDQIDYWKEDFPQMLKNKDYIVDAVINEEEKYNDTISKIPSILSTLSKKSKVDLDELINIYDSNGISPDLILDEARKRNININVEIPHNFYSIVAKKHQNALVRENRKDKIPKEVIDEINNKKIEPTVPLYYKDQYLRTFNAKVLLNYKNFLVLDQTTFYPEGGGQIGDTGIIRSIEGNKQAKVIDTQKYKGVIVHILDKDSPFIQGEQVYGEIDWQRRYRIMKHHTVTHVILSATRRVLGEHAWQAGAEKTEYKGRLDVTHYKLPTEEEIRKIEDFANYIINDRRKVRPLYIERTEAEMKYGVSIYAGGIPEGSEIRLIEIENWDIEGCGGTHLINTGEIGGVKIVNVEKLQDGVIRLEYVAGDMVSNYARQQDEKLNEISKLLNSPVSQINVRLKKHLEEYENLQNLLDKYRKIVLDRIQEIAERISVNGITIYILRDFIDEQLIKEVMRKITSNNQNIVISIRGKDTKNVEIATSKDIKVDKIVDELRKIGGRGGGKGTYGSVSITVEEEKIIDTIRSAITNGV
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EED_CHICK
Sequence: MSERGEAPAAAASAGAGGEMPAKKQKLSSDENSNPGDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHGQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMINAIKESYEYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEIEDPHKAKCTTLTHPKCVAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
What is the function of this protein?
Polycomb group (PcG) protein.  Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity).
What are the official names of this protein?
Polycomb protein EED.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ESC family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNTH_SALTI
Sequence: MTDNRVENSSGRAARKLRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELFFSQPDMAQLGKGMVIPALPNPEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGTRQQRYSATKWDVAIAMTIAGFVNLAMMATAAAAFHFSGHTGIADLDQAYLTLEPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFVRFHIPLWVRRTITMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSNATLMGELVNTRRVKQIGWIIVVLVVALNIWLLVGTVMGLS
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KHSE_STRSV
Sequence: MKIIVPATSANIGPGFDSVGVALSKYLEIEVLEESQEWVIEHDLNPRIPKDRRNLLVKIALQLAPDIQPRRLKMTSDIPLARGLGSSSSVIVAGIELANQLAHLNLSDYQKLKIATKIEGHPDNVAPAIYGNLVVSSSSRNQVSAVVADFPDADFIAYIPDYELRTVESRQVLPNRLSYKEAVAASSIANVAIAALLKGDMKIAGRAIESDLFHEKYRQPLIKEFSDIKFLARKNGSYATYISGAGPTVMVLSPKHKTETIYQLLQKQNFKGQIFRLQVDTEGVRVEK
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_PYRAE
Sequence: MKLHEYEAKELFSKYGVKIPPGKVALTPEEVLKIAREIGAPVVLKAQVVVAGRGKAGGIKVANSPEEAYELSKRMFGMNIKGLIVKKLYVTKFVEVEREMYLSLIIDRASRRYLFLASPVGGMDIEEIAKTSPEKIKRVYVDPATGLRDYHVRSIVSWLGFKQGTSQWQQAASIVQAMYRIMVDYDAELVESNPLAVTKEGEVIPLDARVIVDDNALFKHPELEKALEEDPRDVTEFEAYAKKIGFHYVELDGDVGIIGNGAGLTMATMDLVYHFGGRPANFLDIGGGASREVVKEAVKVLLHHPRVKVIFVNIFGGITRADEVALGIKEALAESGGTNKKIVVRMKGTNEELGRAILAEIGVPLFDSAEEAAKKAVELARV
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: YGFB_SALPC
Sequence: MSIQNEMPGYNEMNRFLNQQGAGLTPAEMHGLISGMICGGNNDSSWQPLLHDLTNEGLAFGHELAQALRKMHAATSDALEDDGFLFQLYLPEGDDVSVFDRADALAGWVNHFLLGLGVTQPKLDKVTGETGEAIDDLRNIAQLGYDESEDQEELEMSLEEIIEYVRVAALLCHDTFTRQQPTAPEVRKPTLH
What are the official names of this protein?
UPF0149 protein YgfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: COX2_DROPE
Sequence: MSTWANLGLQDSASPLMEQLIFFHDHALLILVMITVLVGYLMFMLFFNSYVNRFLLHGQLIEMIWTILPAIILLFIAMPSLRLLYLLDEINEPSITLKSIGHQWYWSYEYSDFNNVEFDSYMIPTNELSNDGFRLLDVDNRIVLPMNSQIRILVTAADVIHSWTVPALGVKVDGTPGRLNQTNFFINRPGLFYGQCSEICGANHSFMPIVIESVPVNYFIKWISNSVNS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.