PharMolix/UniProtQA huggingface dataset:
Protein: ACP_HELPY
Sequence: MALFEDIQAVIAEQLNVDAVQVTPEAEFVKDLGADSLDVVELIMALEEKFGVEIPDEQAEKIINVGDVVKYIEDNKLA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_YERPY
Sequence: MNLLEHMGKAAKQASWQLAMLSTAKKNQALAVIANLLESESQTILQANERDMAAARESGMSEALLDRLLLTPARLAAIANDVRQVCRLNDPVGRVIDGSLLDSGLKLERRRVPLGVIGVIYEARPNVTIDVASLCLKTGNAVILRGGKETHHTNQATVNVIQRALEQCGLPAAAVQAIESPDRQLVNELLRLDRYVDMLIPRGGASLHKLCREQSTIPVITGGIGVCHTFVDENADFEKALLVIENAKIQRPSACNSLETLLVHQAVAKTFLPLLSARMHAFGVTLHASPLAMPYLADGKAKVVAVEAADYDDEWLSLDLNVDIVTDIDAAIDHIREHGTSHSDAILTRSLSHAEYFVRAVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLDALTTYKWIGYGDDLVRS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_BORA1
Sequence: MSSNTVAQFATELKMPANVLLEQLRAAGVDLKSVDDSVTDSDKAKLLDSLRRAHGATDGKKITLTRRQTSEIRQADATGRSRTIQVEVRKKRVFVKRDPAELAAEAAAEAKAAAEQAAAEAVDMQPESVEAQAPAPQSVEALAQAPVEAVKPVEAEAPKIETPPVETPAVEAVEAAAPKIEASEAPAEPVQTQTAQAVEETPAPAETPEPVPAVKAEAEPQSAQPAASREQSTAQPVEPEAKKESVAAPKTQEAGPESVVHAQTDLNSKTPAPVAKSETAPSAPKAAQGRPQVAEAARPPVVNDRAREDARRAAEAEAAALREMLNRPRKVLRAPEPEPAGTNNAALSGTLHKPAGKKDAAAAPAAAPKKEGGNKPAAAGAGGKKVIKTAEVSSTWNDDASRKKPADKAAAPGGNSRDGWRSGGKGGGKNSRNGRNQHQDRRNESAAQEFIAREIHVPETISVADLAHKMSVKAAEVIKQLMKLGQMVTINQVLDQETAMIVVEELGHVAIAAKLDDPEAFLDETPGVSEAEALPRAPVVTVMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETDRGSVTFLDTPGHEAFTAMRARGAKATDIVILVVAADDGVMPQTREAIHHAKAAGVPLVVAVNKIDKPEANPDRVKQELVAEQVVPEEYGGDVPFVPVSAKTGAGIDDLLENVLLQAEILELTAPVEAAAKGIVIEARLDKGRGPVATILVQSGTLKRGDVVLAGASFGRVRAMLDENGKQVQSAGPSIPVEIQGLTEVPAAGDELISLSDERRAREIALFRQGKFRDVKLARQQAAKLESMFDNMGEGTQTLPLIVKTDVQGSQEALVAALTKLSTDEVRVQVVHAAVGGISESDVNLAIASNAVVIGFNVRADQSAKKLADNNGIDLRYYNIIYDAVDEVKAAMSGMLAPEKREEIIGLVEVREVYTISRIGTVAGCMVLDGLVRRDSQVRLLRNNVVTWTGQLDSLRRFKDDVKEVKSGFDCGLTLRGNNDLQMGDQLEVFEIKEIARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THLA_CLOD6
Sequence: MREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKRANITPDMIDESLLGGVLTAGLGQNIARQIALGAGIPVEKPAMTINIVCGSGLRSVSMASQLIALGDADIMLVGGAENMSMSPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMGITAENIAEQWNITREEQDELALASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDEYIKPGTTMEKLAKLRPAFKKDGTVTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIVSYGTAGVDPKIMGYGPVPATKKALEAANMTIEDIDLVEANEAFAAQSVAVIRDLNIDMNKVNVNGGAIAIGHPIGCSGARILTTLLYEMKRRDAKTGLATLCIGGGMGTTLIVKR
What is the function of this protein?
Catalyzes the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA.
What are the official names of this protein?
Acetyl-CoA acetyltransferase, Acetoacetyl-CoA thiolase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_SYNR3
Sequence: MAFSGHHARKRFGQHWLKDESVLQRIVAAAALQPDDHVLEVGPGRGALTAQLLASPAASVQAVELDRDLVAGLQQRFAAEPRFQLQSGDVLALPQLGDGERRPTKVVANIPYNITGPLLERLVGRLDRPVEPPYQRLVLLVQQEVARRISARAGQSSFSALSVRMQLLAHCRSVCPVPPRCFQPPPKVQSEVISLDPLPADQRPPQAVAKQVEHLLRLAFSARRKMVRNTLASAAPAVGLEVWLADAGLTPQQRPQEIAAQQWVALAAALQPAL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACBG2_RAT
Sequence: MTQEKKAEDPDRGMDTTSAAPRLWSTHCDGEVLLRLSKHGPGHETPMTIPELFQESVERFGAYPALASKNGKKWDTLTFSQYYDVCRKAARSLIKLGLQRFHGVGILGFNSVEWVVAALGAILAGGLCVGIYATNSAEACQYVIKQANVNVLIVENDQQLQKILSIPPDKMETVKAIVQYRLPLMENSTNLYSWQDFMELGNAIPNIQLDRVILSQKANQCAVIIYTSGTTGSPKGVMLSHDNITWTAGAMAREIELIHVSGKQDTIVSYLPLSHIAAQLMDIWIPIKVGVLTFFAQPDALRGTLVYTLQEVKPTYFLGVPRVWEKMQDTIKENVAKSSNLRKKAFAWAKMLGLKVNTKKMLGKRDIPMNYRMAKALVFTKVRTSLGLDNCHTFFSGASPLSQDVSEFFLSLDIPIGEIYGMTECSGPHTVSCKSIYRVLSCGKVLNGCKNMLYKQNKDGVGEVCMWGRHVFMGYLGKEDATLEVLDEDGWLHSGDIGRLDSHDFLYITGRIKEVLITAGGENIWPIPIETLVKEKIPIISHAMLVGDKAKFLSMLLTLKCETDQMSGEPLDKLNLEAISFCQMLGSQAVTVSDILKIRDPVVYTAIQYGIDIVNQQAVSDSHRIRKWIILEKDFSIQGGELGPTSKLKRDLITQKYKAQIDNMYSS
What is the function of this protein?
Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.  Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.  Has increased ability to activate oleic and linoleic acid.  May play a role in spermatogenesis.
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase ACSBG2, Acyl-CoA synthetase bubblegum family member 2, Arachidonate--CoA ligase ACSBG2.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: MURG_STREM
Sequence: MTKKIIFTGGGTAGHVTLNLILIPKFIKDGWEVHYIGDDNGIEHQEIKKSGLDVTFHAIATGKLRRYFSWQNLLDAFKVGFGVMQSLFIIARLRPKALFSKGGFVSVPPVIAARLLGVPAFIHESDLSMGLANRIAYRFATTMYTTFEQEQTLVKLKHVGAVTKVTAPKSRSVASKQLAAVSEYFDPNLKTLLFIGGSAGARVFNRFITDHPELKEDFNIINISGDPSLNELSRHLYRVDYVTDLYQPLMEMADLVVTRGGSNTLFELLAMRKLQLIIPLGKEASRGDQLENAHYFTTRGYAEQLLEQELTLPHFQEKVREVFAKQSDYLSAMTSSSELQSPESFYQLLSADISSATKEN
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACT1_STENO
Sequence: MADKQTVVVDNGSGVVKAGFSGEDAPRAVFPSIIGRPKNVSALIGVDSASEYIGDEAQQKRGVLKIFYPIEHGIIKDWEDMEKIWNHTFYVELRVQPDEHPVLLTEAPLNPKTNREKMTQIMFETFNVPALYVAIQAVLSLYSAGRTTGIVCDAGDGVTHTVPIYEGFSIPHAVSRIQLAGRDLTTFMAKLLTEKGYVFTSSAEMEIVRDIKEKLCFVALDYEAAMKQSYESTTFEKNYELPDGRVITIGNARFRCPEYLFKPLEMNGKELDSIQSLTYNSIQECDVDVRRDLYQNITLSGGTTMYEGIGERLLKEIEARAPKSINVKVIASPDRRFAVWRGGSTLTSLSTFASMWITKEDYDENGASIVHRKCL
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, cytoplasmic, Actin, macronuclear.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: DNAA_RICAH
Sequence: MNTNQIILTDQGDNYVNLWSHVAQDLYNHYGETLYNSWFSKVNFIESSLNTVILCAPTNFVRDWIKSKYSMVILQLFQHYNNTIKSIDIITKELPGTTQTVIELPTKTFADIGSSELNSENIFSTLDVRFTFDNFVVGAPNELAYAAARAVAESSGAVSESNPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAEKFMYQFVKALRNKEVILFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLIDNNRQMVISCDRSPSDLDNIEDRIKSRLGWGLVADVHSTTYELRLGILESKIEQMNVKIPKDVIDFLASKIVSNVRELEGALNKVIAHSNFTLKEITLENTQNILRDLLRSNERIITVEDIQKKVASRYNIKLSDMSSSRRLREVARPRQIAMYLSKALTLKSLADIGKKFGKKDHTTVMYAIKKVEELLENDIELREEINLLMKILQH
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABA_VIBCM
Sequence: MQNKRDSYNREDLLASSQGELFGEGYPQLPAPNMLMMDRITKMSETEGEFGKGLILAELDITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLGWVGGKGKGRALGVGEVKFTGQILPTAKKVTYEINMKRVVNRKLVMGLADGRVLVDGKEIYVAKDLKVGLFQDTSAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGGGP_PYRAB
Sequence: MEVKAFIEIMRPHNCILAGVVGILGSLVAYEGIPSIEKLGLVFLVVYLGCSAGNTINDYFDVEIDRVNRPNRPIPRGAIPRKVALYYALLQYMLGLALARFLGVEALLFALGAYALTFIYAWKLKPLPFIGNVAVALLTAATPIYGALGVGRVGLAGYLAICAFLVNVSREIMKDIEDIEGDMKMGAKTLPIIIGKRRAAMISSIFGVLTVITSFLPVKVGIGLGYAPIILVDAMILKASIDVVKNPESASKGQKTLKIATFIAVISFLLGALTKGV
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP).  This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Digeranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, Geranylgeranylglycerol-phosphate geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YEAL_ECO5T
Sequence: MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLSTFFPWIEKQGLSIGIIILTIGVMAPIASGTLPPSTLIHSFLNWKSLVAIAVGVIVSWLGGRGVTLMGSQPQLVAGLLVGTVLGVALFRGVPVGPLIATGLVSLIVGKQ
What are the official names of this protein?
UPF0756 membrane protein YeaL.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PEPE_NOSS1
Sequence: MSKRLLLLSNSTNIGEEYLFYARQEIKNFLGSSVKKIAFIPFAAVTSTYQHYSEKVRKVFQDIGYEFDAIHLVESSHELIKNAEAVVVGGGNTFHLIHCLHETKLLDDIRNKVSNGTPYIGWSAGSNVACPTIKTSNDMPIIEPISFQGLNLVPFQINPHYTNAVIPNHNGETREQRLEDFLVLNPDIYVVGLPEGTMLKIEDSSIRLIGNKTIYLFKFGEEKQEYYPHDNLDFLLERASFT
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISY2_NEPCA
Sequence: MSMNWWRDGAAKKRMDESSAVKLQQQQCVALIVGVTGLVGNSLAEMLPLSDTPGGPWKVYGVARRPRPSWNEDHPINYISCDVSNTAEVEAKLPPLSDVTHIFYATWTSRSSEEENCEANGKMLKNVLDTMIPNCPNLKHICLQTGRFHYVASVVDWKINGSHDTPLTEDLPRLNTNNFYYTQEDILLEEVKRKEGLTWSVHRPGTIFGFSPYSMMNLVGTLCVYAAICKQEGAVLRFPGCKGAWDGYSDCADADLIAEHYIWAALDPHAKNQSFNVSNGDVFKWKHLWKVLAEQFGVECGGYEYEEGQQVRLQDVMKDKGPVWDKIVRENGLSNTKLEDVGKWWFSDTILWNECRLDSMNKSKEHGFLGFRNSKNCFLYWIHKLKAYKIVPSSTIS
What is the function of this protein?
Iridoid synthase that catalyzes the first step in generation of the iridoid ring scaffold using the linear monoterpene (6E)-8-oxogeranial as substrate (PubMed:29091815).  Iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and antibacterial activities (Probable).  Catalyzes the conversion of the linear monoterpene (6E)-8-oxogeranial to (S)-8-oxocitronellyl enol, a precursor of nepetalactones, which are metabolites that are both insect-repellent and have euphoric effect in cats (PubMed:29091815).
What are the official names of this protein?
(S)-8-oxocitronellyl enol synthase ISY2, Iridoid synthase 2, NcISY2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: OPA1_RAT
Sequence: MWRAGRAALACEVCQSLVKHSSGVQRNVPLQKLHLVSRSIYRSHHPALKLQRPQLRTSFQQFSSLTNLSLHKLKLSPTKYGYQPRRNFWPARLAARLLKLRYIILGSAVGGGYTAKKTFDEWKDMIPDLSDYKWIVPDFIWEIDEYIDLEKIRKALPSSEDLANFAPDLDKIAESLSLLKDFFTAGTPGETAFRATDHGSESDKHYRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQDEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQGRLKDTENAIENMIGPDWKKRWIYWKNRTQEQCVHNETKNELEKMLKVNDEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFIDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKVKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
What is the function of this protein?
Isoforms that contain the alternative exon 4b (present in isoform 2 and isoform 3, but not in isoform 1) are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane.
What are the official names of this protein?
Dynamin-like 120 kDa protein, mitochondrial, Optic atrophy protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space. Mitochondrion membrane. Note=Detected at contact sites between endoplasmic reticulum and mitochondrion membranes.
Protein: Y1050_HAEIN
Sequence: MKKLCTALLLSLFAISFAHANETKQIVLKVKEMNCQLCAYLVNKELRNINGVISTKASIKDGLVTVVEDPNVTNQQLFDAIHKLKYTAEVVN
What are the official names of this protein?
Uncharacterized protein HI_1050.
Protein: YBAM_ECOLI
Sequence: MSLENAPDDVKLAVDLIVLLEENQIPASTVLRALDIVKRDYEKKLTRDDEAEK
What are the official names of this protein?
Uncharacterized protein YbaM.
Protein: HIS6_BACLD
Sequence: MITKRIIPCLDVKDGRVVKGVQFVELKDAGDPVELAEVYDHEGADELVFLDISASHEGRKTMVDVVERVAAKLAIPFTVGGGINRLDDMKTILRAGADKVSVNTAAVLRPELITEGADFFGSQCIVVAIDAKYDPEADLYYVYTHGGRKKTNLEAVSWAKEAVRRGAGEILLTSMDSDGEKNGFDCRLTKLVSEAVSVPVIASGGAGRADHMYDAFAEGRADAALAASIFHYKETSVKEVKAYLKERGVNVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENC_PROMH
Sequence: MRNAKLYSFSLPMEAGVVLRYQRLKTRDGFLVCLEQNGKQGWGEISPLPEFSHETLEQAQDAAQSWLAAWCLGENPTDSELPSVAFGISCALAELEGTLPEEANYRAAPLCNGDPDDLILSLNEMSGEKVAKVKVGLYEAVRDGIVVNLLLEAIPDLKLRLDANRSWTPAKAEGFAKYVNPQWRDRIAFLEEPCKTPEESLAFSQATGINIAWDETVRDEGFEVKAQEGVTAIVIKPTLVGSLARCQSIVEQAHALGLEAIISSSIESSFGLTQLARVAQWLTPDSIPGLDTVDLIKQQLIRCWPDVDIPLITLEQLKTVWQQ
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: RS7_DESRM
Sequence: MPRRGGIPKRDVLPDPIYGSKIATKLVNQMMLDGKRGVAEKIIYDAFEIIKEKTGKSPLEVFDAAMKNVMPVLEVKARRVGGANYQVPVEVRAERRQTLGIRWMVLFTRKRAGKSMAEKLAAEIMDAANNTGATVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: CH60B_DROME
Sequence: MFRSCVPKAITSSRCFARMYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFTVARSIALKDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGTITVKDGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLIIIAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDDINYSKMEEAKLEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQDELAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEEGIVPGGGTAFLRCIPYLQELKTESADLQKGVDIVCNALRMPCQTIAQNAGVDGPMVVAKVLNGSEDYGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVASLLSTTEVVITDSRNDDLLSKLSGAGGGMDDGLDMNMGGLEELAALSGLGGMGGMGGMGGMGGMGGMGGGFGGMGAGGGMSASASNDGPTAEEMNEMVKAIPGMEQVEVRDIDSGMM
What is the function of this protein?
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
What are the official names of this protein?
60 kDa heat shock protein homolog 1, mitochondrial, 60 kDa chaperonin, CPN60, Heat shock protein 60, HSP-60, Hsp60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: DJB11_RAT
Sequence: MAPQNLSTFCLLLLYLIGAVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPQAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGAPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHRIFERRGDDLYTNVTVSLVEALVGFEMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEEAKEGIKQLLKQGPVQKVYNGLQGY
What is the function of this protein?
As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins.  Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed.  May help recruiting HSPA5 and other chaperones to the substrate.  Stimulates HSPA5 ATPase activity.  It is necessary for maturation and correct trafficking of PKD1.
What are the official names of this protein?
DnaJ homolog subfamily B member 11, ER-associated DNAJ, ER-associated Hsp40 co-chaperone, Endoplasmic reticulum DNA J domain-containing protein 3, ER-resident protein ERdj3, ERdj3, ERj3p, Liver regeneration-related protein LRRGT00084.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: VS48_BRSV
Sequence: MKSYFCVTPSGWQETQTRPRIVPKHSEKCSRTYSRPRSSLSDSEGRCVVLPRDGGGRKRKSNGSQGRCSNNPGRPSRKWTEKTIAASRQGFFSKRDNGYWVPKSPEKKYVPKVFPRNMDNKKSFKDVLTSPAKIQIKPTPESILLAQKIQNSTFKSRGKVTLSQFSLPLINRFQEIQLTTHLEPVEESTPFGVNDQRAQHLFCKKVPRKIGRNTVLVCPITGTESHIDAKRGISARIVDSMASVVHTENLPAYERGHVVTKNVSRTKRVCTPVPIIGTFSDRAIRVECDDHTDELASASSVPSIWKPSKKQHAVPISSSNEMGSAVGTKPDWYTPVKTCTHRQYQKVQRVFLDAMNIMRTLRFHTGPQELRETWVKCWLQVHKKNVAFPGWMITPLLSGTVPCEQEFFLPKAGETRGFATVCYA
What are the official names of this protein?
Satellite RNA 48 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the nepovirus satellite RNA 48 kDa protein family.
Protein: RS19_LEGPL
Sequence: MARSIRKGPFIDHHLISKVEAAIESKSKKPIKTWSRRSTIVPEMIDLTIAVHNGKDHVPVFITDNMVGHKLGEFAMTRTFKGHSGDRKAKGK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: YMDB_ECO57
Sequence: MKTRIHVVQGDITKLAVDVIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDCPTGHAVITLAGDLPAKAVVHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPAISTGVYGYPRAAAAEIAVKTVSEFITRHALPEQVYFVCYDEENAHLYERLLTQQGDE
What is the function of this protein?
Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate.  Down-regulates ribonuclease 3 (RNase III) activity.  Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
What are the official names of this protein?
O-acetyl-ADP-ribose deacetylase, Regulator of RNase III activity.
What is the protein family that this protein belongs to?
Belongs to the YmdB family.
Protein: SSUB1_PSE14
Sequence: MPESLMNIRVDRKAFAGNTVLQDIDLSLQSGEIVSLLGPSGCGKSTLLRIVAGLEQDFRGSVDNIEGEVAFVFQEPRLMPWLTVEQNIGFSDDAGYDRRWVGQLIEEVGLSGFADALPKALSGGMAQRVAIARGLYSHPTVLLLDEPFSAVDAFTRMKLQDLLLQLAERHAITLLLVTHDVDEALYLSDRVLVMGSRPGTITQQLPVGLQAPRDRRDPLLARLKAQALTELHQAHII
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.