PharMolix/UniProtQA huggingface dataset:
Protein: M3K15_HUMAN
Sequence: MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGGGPRRALRAVYVRSESSQGGAAGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSCVYYKETLLNDIRKAREKYQGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDMFCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETSLELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVWYLRSLVQNLLLIRRFKKTIIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKDKA
What is the function of this protein?
May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 15, Apoptosis signal-regulating kinase 3, MAPK/ERK kinase kinase 15, MEK kinase 15, MEKK 15.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Protein: ACTL3_HYDVU
Sequence: LEATVSRNKKYKFTMGNVVRSWKCTVENKSNKTLYADGSTPVSGSMATVLTDIAPGGTGVFLWEQSKGAARGAVGVVYYRYEDKILSLMASIPYDWHLYNAWANARVSNKKESFSNLYNGYDGAQQPTIAGNWGEVDGTKFFLTDKSHAEFNVIFSG
What is the function of this protein?
Pore-forming protein that forms hydrophilic pores and causes cytolysis (PubMed:31513812).  Compared to equinatoxin-2 (AC P61914), it reveals lower cytolysis activity (5-12-fold difference, tested on erythrocytes), a larger pore size (probably 2-3 nm) and different affinity to membrane lipids (100-fold lower affinity to sphingomyelin) (By similarity).  Binds to the two sphingolipids, lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) (PubMed:31513812).  Does not bind (or only weakly) to sulfatides (SFT) (PubMed:31513812).  Shows cytolytic activity on HeLa cells, with a different potency than its paralogs (from most potent to less potent: HALT-4>HALT-6~HALT-1>HALT-3>HALT-7>HALT-2) (PubMed:31513812).  Pore formation is a multi-step process that involves specific recognition of membrane lipid by a protein aromatic residues rich region, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers (By similarity).  In vitro, binds to the folate receptor alpha (FOLR1), a GPI-anchored membrane protein that plays a major role in the uptake of folate/folic acid into cells via endocytosis, suggesting a possible involvement of this receptor in the mechanism of HALT-1-induced cell lysis (By similarity).  In vivo, does not cause visible paralysis in larvae of the blowfly Sarcophaga faculata, the most common arthropod prey of Hydra (By similarity).
What are the official names of this protein?
Hydra actinoporin-like toxin 3, HALT-3, Alpha-pore-forming toxin, alpha-PFT, DELTA-hydritoxin-Hma1c, DELTA-HYTX-Hma1c.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. HALT subfamily.
Protein: Y030_OSHVF
Sequence: MKRSYDSINECGAYINNAADNICQCKMNRIDSAFGGWLTNLTEVYYCPTHNIYHHCDGDGTCIIVNSVCTRSGTCMGISTLVGVTHDLMDIDSLPAFDRFKLRMMNKGYFWISMQDRLKEELEEAKSGDEGMTMETHFRNKPDVESTLTRLYYYFKRELGMITRGTQESKLEKVYIMFEEMALRLLESRMTNHDKKQKLLAKVSKLISKQNTKSHFTTSVNKLITSDLTYPERIVKPLMDLKLSELYI
What are the official names of this protein?
Uncharacterized protein ORF30.
Protein: TIG1_DESHY
Sequence: MSVKMEKIEKNTVELEVTVDAKVFSAAVTKAAKALANKVNIPGFRKGKAPRTMVERYVGTAALYNDAVDDILGVEYMKAVNEAGIEPVDRPDVDLIQMEDGKELVFKAKVTVKPEVELGSYKGLEVEKTAAVVTDEELEQELQRKQEQHAKVLNLEEGTVQAQDTVNIDFAGSVDGVAFEGGTAEGYDLVIGSGSFIPGFEEQLIGAQIGQEVDVNVRFPDEYHVADLQGKDALFKVKVNKLKRKEYAPLDDEFAKDISEFETLDELKADLRDKLMTAAEQRAEMEQKNAIVAKAVENASVEIPEAMVNSRIDMMLDDMAQNLSYQGLDLETYCHYTGTSMDTMREELRPRASENLKTELVLEAIAKVEGITVSEEELNNELAKLAERYQTSPENLKQALMARGDMGMYRQSLVSEKTVNFLVEQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor 1, TF 1, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: LPLT_ECO24
Sequence: MSESVHTNTSLWSKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSKLVKANGLMEASTIAAILLGSVAGGVLADWHVLVALAACALAYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVLIFSLQHELLPAYALLMLIGVMGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGIYSLAVMVGIPVVPIGIGFGALFALAITALWIWQRRH
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SMS_MYXGL
Sequence: AVERPRQDGQVHEPPGRERKAGCKNFFWKTFTSC
What is the function of this protein?
Somatostatin inhibits the release of somatotropin.
What are the official names of this protein?
Somatostatin.
What is the protein family that this protein belongs to?
Belongs to the somatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: BGBP1_MANSE
Sequence: MLKSVFVLFLVNYLNSVRCLEVPDAKLEAIYPKGLRVSIPDDGYTLFAFHGKLNEEMEGLEAGHWSRDITKAKNGRWIFRDRNAKLKIGDKIYFWTYILKDGLGYRQDNGEWTVTGYVNEDGEPLDANFEPRSTASTAAPPQAGAGQAPGPSYPCELSVSEVSVPGFVCKGQMLFEDNFNKPLADGRIWTPEIMFPGEPDYPFNVYMKETDNLHVGNGNLVIKPMPLVTAFGEDAIWKTLDLSDRCTGLLGTAQCKRDPSDAIIVPPIVTAKINTKKTFAFKYGRVEISAKMPRGDWLVPLIQLEPVNKNYGIRNYVSGLLRVACVKGNTEYIKTLVGGPIMSEAEPYRTANLKEFISNEPWTNEFHNYTLEWSPDAITMAVDGIVYGRVTAPAGGFYKEANEQNVEAAARWIQGSNIAPFDDMFYISLGMDVGGVHEFPDEAINKPWKNTATKAMVNFWNARSQWNPTWLESEKALLVDYVRVYAL
What is the function of this protein?
Involved in the recognition of invading microorganisms.  Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade.  Causes aggregation of invading microorganisms.
What are the official names of this protein?
Beta-1,3-glucan-binding protein 1, BGBP-1, Beta-1,3-glucan recognition protein 1, BetaGRP-1.
What is the protein family that this protein belongs to?
Belongs to the insect beta-1,3-glucan binding protein family.
Protein: RISB_CUPNH
Sequence: MDHGFYPSNLDGEGLRIGIVQARFNEPVCAELLEACVAELEKLGVEGEDTLVVTVPGALEIPLALQKMCESGQFDALVALGAVVRGETYHFELVSNESGAGITRVGLDFNVPIANGILTVDTDEQAHARTREKGRDCARAAVEMANLVAALDSLRGQEDEDEDDDE
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RL9_CUPPJ
Sequence: MQIILLEKVINLGNLGDIVKVKDGYARNFLIPSKKARRATQTAIQEFEVKRAELEKAAAEKLAAAQAEGEKLNGQTVQISQKSGVDGRLFGSVTNADIAIALGTQGFKVEKAQVRLPNGPLKTVGEHPVAVALHTDVVVDVTVAVVGEQV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: EIF3K_CAEBR
Sequence: MSFERLQRDLHEAIEGVNRYNPENVAELAACVQAMVAENKYDKDIVLTILKLYQLNPERYDENVVRQVLLKTLMVLPSSDFALAKCLIDTNRIGSQELRRIFDLGAVLESCNFAVFWKLMKGTYKPTTNPNEPFKVPAEISKMIKPMAGFEDAIKHYACRVISVTFQNIEKKLLSSLLGGASDKEVTALAKKFGWETKENGEVFFVANHEGTIKTRNIDEKIQFSHVADLLTSNVPPLAF
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit K, eIF3k, eIF-3 p25.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit K family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGFR4_DANRE
Sequence: MLSILKVFIAICFMELVCSRSITSGEPRAKDIRVSRHILTPGYPENATVLVGGHVKLVCKLHQPASTRLQWFKKDSNRLGPDGSPVLTALTPLLENLSKVNIFPLVNISLEDAGEYVCKAENSAGQATRSAWVEVLSEVSEEPTEEPSEHLLLELGDVLKLRCDTNRPGAVQWFKSGVRVQHNARIQIRAAVMEIADVTYEDSGVYVCMLRGTKEALRNFTITVADAVGSGDDDDEDNGLDDIGPETENDQVYISRAPYWTHTQRMEKKLYAVPAGNTVKFRCPATGSPLPTIRWLKNGREFRGEHRIGGIKLRHQHWSLVMESVVPSDRGNYSCVVENKYGSIAHTYLLDVLERSPHRPILQAGLPKNTTAIVGGDAQFLCKVYSDAQPHIQWLKHIEMNGSRYGPDGIPYVKIVKTGSLNMSEVEVLYLTNISMEDAGEYSCLAGNSIGFSHQSAWLTVLSEEDVAKEVDLMEAKYTDIIIYASGFLALVMAIVIVVLCRMQVHPSREPFDTLPVQKLSKFPLRRQYSVESNSSGKSSASLMRVARLSSSCSPMLAGVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEAYGINKENQDHMATVAVKMLKDDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTFKDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKTTNGRMPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEELDRVLVSISDEYLDLSTPFEQYSPSCEDTSSSCSSDNDSVFTHDALSTEPCLLGYHDVHSRMDLKTTMR
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.  Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.  Phosphorylates PLCG1 and FRS2.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).
What are the official names of this protein?
Fibroblast growth factor receptor 4, FGFR-4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.
Protein: ASSY_CORGB
Sequence: MTNRIVLAYSGGLDTTVAIPYLKKMIDGEVIAVSLDLGQGGENLDNVRQRALDAGAAESIVVDAKDEFAEEYCLPTIKANGMYMKQYPLVSAISRPLIVKHLVEAGKQFNGTHVAHGCTGKGNDQVRFEVGFMDTDPNLEIIAPARDFAWTRDKAIAFAEENNVPIEQSVKSPFSIDQNVWGRAIETGYLEDLWNAPTKDIYAYTEDPALGNAPDEVIISFEGGKPVSIDGRPVSVLQAIEELNRRAGAQGVGRLDMVEDRLVGIKSREIYEAPGAIALIKAHEALEDVTIERELARYKRGVDARWAEEVYDGLWFGPLKRSLDAFIDSTQEHVTGDIRMVLHAGSITINGRRSSHSLYDFNLATYDTGDTFDQTLAKGFVQLHGLSSKIANKRDREAGNN
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR12_ILLOL
Sequence: MPTIKQLIRNTRQPIKNVTKSPALRGCPQRRGTCTRVTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNSQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSKYGVKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UFL1_DANRE
Sequence: MAADWEEIRRLAADFQRAQFAETVQRLSERNCIEIVSKLVEDKKLDVVHTLDGKEYVTPAQISREIRDELYMHRGRINVVDLQKIINVDLVHVEGRANEIAKSDRGTQLILGQLIDEAYLDRLAEEVNDKLQEAGQVNIAELCKTYDLPGDFLTEALNARLGRVIQGQLDQYNRGMIFTQAFLSRHKACICGLFSGITRPTQINNLLNLYGFQENLVYSMLEELVNSARLKGSVVGGRQDKAIYIPDIYSKAQSTWVESFLKQNGYLEFESLTRLGIPDPINYIKKRFKSSRLLFLKTACVGRTIVDQLEASVEEAINSATWVDLQPMLPSILSEEDVGILLNEVLRSMNVQSSARLLSTSVVSEKFIAGCIALFEDLMQQKAQKEVKNNPVFLITEDDVKQSSALLETSASSKKDKRDERRKKAAEGGGSVKSGGGGNAREIRIRKTKKKGRKEEDSDEETTHSSQGRNKLGDVQFLSVEEIVEVLEEKVCDSSEEMLQELAEQLQRPLSKMYQEVVTTAFLSTSSSGAGGSRKKNMKDLQEEINNLYNNIRLFEKGTKLFSDETQATVAKHVLKTVCTDVTNVLLSFVAAEHMTSDSSAAMTSEIRLKILAKLSDEVRSPLMKLHNSLNGKAIEEFLSCLETSAEECGLFLKKGDKKRERQALSVHRQALCEQLRDAEDPALVLHLTSVLLFQNVTHCMLHAPGRCVPHIIGFLQSKIPEDQHKLLSQYQSLVVKQLVVQGHGAEKKTVPPEGAGGPADSDDTESLQRELHSLSRDIKDTVLAQRKPSVTE
What is the function of this protein?
E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.  In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane, and mediates ufmylation of proteins, thereby promoting reticulophagy of endoplasmic reticulum sheets.  Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR).  Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response.  Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 (By similarity).  Required for hematopoietic stem cell function and hematopoiesis (By similarity).
What are the official names of this protein?
E3 UFM1-protein ligase 1, E3 UFM1-protein transferase 1.
What is the protein family that this protein belongs to?
Belongs to the UFL1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Cytoplasm, cytosol. Nucleus. Chromosome. Note=Recruited to double- strand breaks following DNA damage.
Protein: PRIB_SHEB5
Sequence: MTTNNLVLSGTITRSRRFKSPAGIAHSVIMLEHKSQRYEADMLRNVYVQIQVILSGPRFESVAEDLKAGVEVQVQGFMTLQQGRNGQNRLVIHAENVELKT
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: YEAV_ECOLI
Sequence: MVLLAMGLVIYLATSKYGNIRLGEGKPEYSTLSWLFMFICAGLGSSTLYWGVAEWAYYYQTPGLNIAPRSQQALEFSVPYSFFHWGISAWATYTLASLIMAYHFHVRKNKGLSLSGIIAAITGVRPQGPWGKLVDLMFLIATVGALTISLVVTAATFTRGLSALTGLPDNFTVQAFVILLSGGIFCLSSWIGINNGLQRLSKMVGWGAFLLPLLVLIVGPTEFITNSIINAIGLTTQNFLQMSLFTDPLGDGSFTRNWTVFYWLWWISYTPGVAMFVTRVSRGRKIKEVIWGLILGSTVGCWFFFGVMESYAIHQFINGVINVPQVLETLGGETAVQQVLMSLPAGKLFLAAYLGVMIIFLASHMDAVAYTMAATSTRNLQEGDDPDRGLRLFWCVVITLIPLSILFTGASLETMKTTVVLTALPFLVILLVKVGGFIRWLKQDYADIPAHQVEHYLPQTPVEALEKTPVLPAGTVFKGDN
What is the function of this protein?
Probable transporter whose substrate is unknown.  Is not involved in aerobic D-malate transport.
What are the official names of this protein?
Uncharacterized transporter YeaV.
What is the protein family that this protein belongs to?
Belongs to the BCCT transporter (TC 2.A.15) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PRHH_PENBI
Sequence: MEEPLTVAAIFRDPFNILAISEVLKVVAAVGWSVNYIGMVHRAWKDQIPSIGILPLCCDIGWEFVYAWMFPDFSSHWQGVVRVWFFLHSAVLLVTLKVSPNDWVHTPLGHRHIVFIYIFVTLVFGAGQYALAAEIGPALGFHWGGALCQFLSSSCGIAQLLSRGHTRGASYLIWFARAISTFAGFIKLCIRFQHNVDGAPWLDSPMCWFYIVTVLSFDAAYPFLYSSMRKLETPALRKESRIKNQ
What is the function of this protein?
Terpene cyclase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture (PubMed:27602587).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity).  Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity).  The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B (PubMed:27602587).  The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK (PubMed:27602587).  Finally, prhA leads to berkeleydione via the berkeleyone B intermediate (PubMed:27602587, PubMed:29317628).  PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione (PubMed:27602587, PubMed:29317628).  Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable).  The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable).  Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable).
What are the official names of this protein?
Terpene cyclase prhH, Paraherquonin biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the paxB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PPK1_MYCTU
Sequence: MMSNDRKVTEIENSPVTEVRPEEHAWYPDDSALAAPPAATPAAISDQLPSDRYLNRELSWLDFNARVLALAADKSMPLLERAKFLAIFASNLDEFYMVRVAGLKRRDEMGLSVRSADGLTPREQLGRIGEQTQQLASRHARVFLDSVLPALGEEGIYIVTWADLDQAERDRLSTYFNEQVFPVLTPLAVDPAHPFPFVSGLSLNLAVTVRQPEDGTQHFARVKVPDNVDRFVELAAREASEEAAGTEGRTALRFLPMEELIAAFLPVLFPGMEIVEHHAFRITRNADFEVEEDRDEDLLQALERELARRRFGSPVRLEIADDMTESMLELLLRELDVHPGDVIEVPGLLDLSSLWQIYAVDRPTLKDRTFVPATHPAFAERETPKSIFATLREGDVLVHHPYDSFSTSVQRFIEQAAADPNVLAIKQTLYRTSGDSPIVRALIDAAEAGKQVVALVEIKARFDEQANIAWARALEQAGVHVAYGLVGLKTHCKTALVVRREGPTIRRYCHVGTGNYNSKTARLYEDVGLLTAAPDIGADLTDLFNSLTGYSRKLSYRNLLVAPHGIRAGIIDRVEREVAAHRAEGAHNGKGRIRLKMNALVDEQVIDALYRASRAGVRIEVVVRGICALRPGAQGISENIIVRSILGRFLEHSRILHFRAIDEFWIGSADMMHRNLDRRVEVMAQVKNPRLTAQLDELFESALDPCTRCWELGPDGQWTASPQEGHSVRDHQESLMERHRSP
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: CLSA_YERPP
Sequence: MTTFYTVISWLSVFGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSFGELHLGKRRAERAKAMWPSTARWLSELKECQHIFANSNSEVASPLFQLCERRQGINGVKGNQLQLLTTTDDTLKALVRDIELARHNIEMVFYIWQPGGLVDQVAESLMAAARRGVHCRLLLDSAGSKQFFRSPYPAMMRNAGIEVVEALKVNVFRMFLRRMDLRQHRKIVLIDNYVAYTGSMNMVDPRFFKQDAGVGQWIDMMARMEGPVATTLGIVYACDWEIETGKRILPPPPDANIMPFEEETGHTIQVIASGPGFPEEMIHQALLTAVYAAREQLIMTTPYFVPSDDLLHAICTAAQRGVDVSIIVPRENDSMMVRWASRAFFTELLNAGVKIYQFEGGLLHSKSVLVDGQLSLVGTVNLDMRSLWLNFEITLVIDDDGFGADLAQVQDDYIARSALLDGERWNKRPLWHRVTERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS9_STRSV
Sequence: MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLVINQPFAVTSTAGSYDVFVNVVGGGYAGQAGAIRHGIARALLQVDPDFRDSLKRAGLLTRDSRKVERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: G1L4_ORYSJ
Sequence: MDLSPNPDSPPSGGGNGGGGGSSSSNSSPSMGAGAPQSPSRYEAQKRRDWNTFGQYLRNHRPPLSLAQCSGAHVLEFLRYLDQFGKTKVHTAACPFFGHPSPPAPCPCPLRQAWGSLDALVGRLRAAFEENGGRPESNPFAARAVRLYLREVREHQARARGVSYEKKKRKKPQQQQLQGGDSSGLHGHQHHPPPPPPAGAAC
What is the function of this protein?
Probable transcription regulator that acts as a developmental regulator by promoting cell growth in response to light.
What are the official names of this protein?
Protein G1-like4.
What is the protein family that this protein belongs to?
Belongs to the plant homeotic and developmental regulators ALOG protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HXK_SCHOC
Sequence: MVHLGPKPPQHRKGSFLDVPEYLLKELTELEGLLTVSGETLRKITDHFISELEKGLSKQGGNIPMIPGWVMDFPTGKEMGDYLAIDLGGTNLRVVLVKLGGNRDFDTTQSKFALPENMRTAKSEELWEFIAECLQKFVEEEFRNGVLSNLPLGFTFSYPASQGSINEGYLQRWTKGFDIEGVEGHDVVPMLQAAIEKRKVPIEVVALINDTTGTLVASMYTDPEAKMGLFSGTGCNGAYYDVVDNIPKLEGKVPDDIKSSSPMAINCEYGAFDNEHIILPRTKYDIQIDEESPRPGQQAFEKMISGYYLGEVLRLILLDLTSKQLIFKDQDLSKLQVPFILDTSIPARIEEDPFENLSDVQELFQEILGIQTTSPERKIIRRLAELIGERSARLSICGIAAICKKRGYKTAHCAADGSVYNKYPGFKERAAKGLRDIFQWESEEDPIVIVPAEDGLGAGAAIIAALTEKRLKDGLPLV
What is the function of this protein?
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively).  Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.
What are the official names of this protein?
Hexokinase.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
Protein: NADE_CAMJD
Sequence: MDWQKITEKMCDFIQEKVKNSQSQGVVLGLSGGIDSALVATLCKRALKENVFAFLMPTQISNKTNLEDALRLCVDLNLEYKIIEIQSILDAFIKQSENTTLVSLGNFAARIRMSLLYDYSAMKNSLVIGTSNKSELLLGYGTIYGDLAYAFNPIGSLYKSEIYALAKYLNLHENFIKKTPSADLWENQTDEADLGFSYAKIDEGLKALETNDEKLLKILDPSLIAMLKNRMQKNAFKGKMPEILEI
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.