PharMolix/UniProtQA huggingface dataset:
Protein: MF6LA_XENLA
Sequence: MSSTKQWDISKALTVATLFYFFHNVGKFCLMPFLTLYFRQLGLGAPLVGIIFGFKHAVHLLWAPLCSFLAKNHHKQRFFIMTSLLLSAGVGSLFAYYPPLDKNIVSLFCNTSMPWKEQLNPPIDISVSVDENLNTTYAAPTDHQTTTGALNTLPSSVGKLATDPAMTSLDLEITTHQRFTDQFPVTSNTILEHQTKNVLGSGKAQKVMSSKSAASNSKQRSSLNNHTSPYATHPNVSHHPSIHERKVRDIGIDFTDNSLDPQHKIFLIVLVLVIIWEILAAPLEWIADDSLYEYLDFVDATDRHGKLWIWGYLGASMGSIFITFLVDNLNCFVIYDIPRVFFHFFCYGGFLIGTLFLSTLYPIHVSKKTEHSNKTVKALGFLGSDGRIVLTALTVFLLGAVGSTTQNFLFWQMQDVGSSELYMGLSIAVGLLSELTLYFFRNKLLKIFTFKWMVALGLFSLGVQCLYYSFLWAPWSVLAIQILNAFSSGVIWWAINSQVVDLASPGTERSLQLALRWLAYGCGSSTGSFASGFIISRFSLAVLYQACCITLLLWIIIFLLVQPKLPNTKKINYSRLLAADNSDMSDSDEEQDRDWLVTAMKDENSNRNW
What are the official names of this protein?
Major facilitator superfamily domain-containing protein 6-like protein A.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. MFSD6 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: US17_HCMVA
Sequence: MSPNSEATGTAWAPPPPRPSRGVIMISSVSTNDVRRFLLCMRVYSTVAVQGTCTFLLCLGLVLAFPHLKGTVFLCCTGFMPPLSLMVPTICLALLHGKRDEGSFTSPPSPGLLTIYSVLTTLSVIVASACSSSTLVTFSGLLACVLFSLCSCVTGLAGHNHRRWQVIVTLFVIGVIAFLIALYLQPVPLGHKLFLGYYAMALSFMLVVTVFDTTRLFEIAWSEADLLTLCLYENLVYLYLLILILFTTEDSLDKLIAWMTWLSSRATGATNAASISGCDLLREVQRNLTRTMA
What are the official names of this protein?
Uncharacterized protein HVLF1.
What is the protein family that this protein belongs to?
Belongs to the cytomegalovirus US12 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: COX1_POLSX
Sequence: FWFFGHPEVYILILPGFGMISHIVAYYSGKNEPFGYMGMVWAMMAIGLLGFIVWAHHMYTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGAIKWETPMLWALGFIFLFTVGGLTGIILANSSLDIMLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLHSTWTKIHFGVMF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL3_NEIM0
Sequence: MTLGLVGRKVGMTRVFDEQGVSVPVTVLDMSANRVTQVKSKDTDGYTAVQVTFGQKKANRVNKAEAGHFAKAGVEAGRGLIEFALTEEKLAELKAGDEITVSMFEVGQLVDVTGISKGKGFSGTIKRHNFGAQRTSHGNSRSHRVPGSIGMAQDPGRVFPGKRMAGQYGNTKATVQKLEVVRVDAERQLLLVKGAVPGAVNSDVVVRPSVKVGA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: URK_GEOKA
Sequence: MGKKPVVIGVAGGSGSGKTSVARAIYDHFGDRSILVLEQDFYYKDQSHLPFEERLKTNYDHPLAFDNDLLIEHIHKLLRYEPIDKPVYDYTLHTRSSDVIRVEPKDVIIVEGILVLEDERLRNLMDIKVYVDTDPDIRIIRRLIRDIKERGRTFDSVIEQYLSVVRPMHNQFVEPTKRYADVIIPEGGQNVVAIDLMVAKIRTVLEQKAVL
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_LEPIC
Sequence: MMLTLALPKGRLAEESIDLMISKGWLSSKPDPNSKELIYNDPKGKIRILLVRSQDVATYVEQCAADAGISGWDVLKEGGYDLATPLDLKIGKCRLSLAAPNGFTLEAHHRKIRVATKYPNLAREFFFLKGLSCEIFKLYGSIELAPLVGLSDCIVDLVSTGGTLKANGLKELDIILESSARLVFNRSSLYGKRKEAVEFMDSLSKI
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_HALMA
Sequence: MADNEEDVEAEEEYTELTDISGVGPSKAESLREAGFESVEDVRGADQSALADVSGIGNALAARIKADVGGLEVESETEAEVEEEGGEEAPDEDVETELQARGLTEKTPDLSDEDARLLTQRHRVGKPQFNRQDHHKKKRVSTSWRKPRGQLSKQRRGIKGKGDTVEAGFRSPTAVRGKHPSGFEEVRVHNVDDLEGVDGDTEAVRIASKVGARKRERIEEEAEDAGIRVLNPTYVEVEVSE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L32e, Hl5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
Protein: RS8_YERPA
Sequence: MSMQDPIADMLTRIRNGQAANKVAVTMPSSKLKVAIANVLKEEGFIEDFKIEGDTKPVLELALKYFQGKAVVESIQRISRPGLRIYKKKDELPKVMAGLGIAVISTSKGVMTDRAARQAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: LPTD_NITEC
Sequence: MSLLSKLHLILYICLLLLPLRFVNAEQLSGSGESQPVHIEADRIDGHYQQEIEATGNVRMRRGDQTLSADHVKYYQDTEDVEVKGNALLERPDDTLWGTFLQMNLQTDIGELRDPRYALKGGNGRGSGSLLLLEGENQYRIKKARYTTCPEDNHDWYILADDLEIDNEKKVGTARHASIRFKDVPILYLPWMNFSFSKERKTGFLSPIMGNTSRSGVEVSVPFYWNIAPNYDATITPRLMSRRGVMLDNEFRYIGQGLGGRLQFDYLPNDLVTDTTRYGLQFNHSQFLGSGWFGALNYNRVSDHNYFRDLGNNILFTSQVNLLQQATASYFSELGRNGMLTFSTLMQQFQTVQDPRAPIISPFKILPRFTLNAVKSNVYGLDFDLASSFTHFSHPTLPHGLRFTAFPSVALPLENSFGFIRPRVGLHYTKYDLNTPAFPGTNDKHPDRSVPIFSLDSGVVLERDMTLGGGNFIQTLEPRVFYTYIPYREQRLLPNFDSAEMDFSFAQLFMEKRFSGEDRINDANEITLAMSSRLIHSATGNERLRFSVGQRIRFSDRRVLLTSPQVTRAGSDFIAELSGSLAQHVKTDAGIQLNQNNLLIEKIRTGISYNPAPGQVINAGYRFTRDVLEQVDLSTQWPFLKRWQGFAAINYSLKNDKLLAGLLGLEYNACCWSLRLVASRFTTATQKTSTNIFVQLELNDLMRIGTNPIRVLQQSIPGYVRTDLQ
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: PA2HA_SISTE
Sequence: MRALWIVAVLLLGVEGSLVEFETLIMKIAGRSGVWYYSSYGCYCGTGGQGWPQDASDRCCFEHDCCYAKLTGCDPITDVYTYRQEDGEIVCGGEDPCGTQICECDKAAAICFRDSMDTYNHKYWRFSLENCQGESQPC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini.
What are the official names of this protein?
Acidic phospholipase A2 homolog sistruxin A, SA, svPLA2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EFG_PARMW
Sequence: MARDFPLERVRNIGIAAHIDAGKTTTTERILFYSGVVHKIGEVHDGAAVTDWMAQERERGITITAAAISTSWQDHRINIIDTPGHVDFTIEVERSMRVLDGVIAVFCAVGGVQPQSETVWRQADRYSVPRMVFVNKMDRTGADFLKVHGQIKDRLKANAVPIQLPIGAEGDLSGIIDLVGNKAYIYKNDLGTDIEEAEIPAEMADEAAEWRATLMETIAETDEALIEKFLETGELSTEELKKGIREGVLKHGLVPMLCGSAFKNKGVQLVLDAVIDYLPAPVDVPPIQGVLPDGKEAVRPSDDKAPFSALAFKVMADPYGKLTFVRMYSGILEKGSYVLNSTKGEKERISRLVVLKADDREEVDALRAGDLGAVLGLKNTTTGDTLCTQDDPIVLETLFIPEPVISVAVEPKTKGDMEKLSKALVSLAEEDPTFRVNTDSETGQTVIAGMGELHLEILVDRMLREFKVEANIGAPQVSYRETIRGSAGGEGKFSRQTGGKGQYGHVVIEMEPGEPGSGFEFVNKIVGGIVPKEYIKPAEQGMRETCESGVIAGYPLIDVRCTLVHGSYHDVDSSEMAFKIAGSMAFKDGVKKCNPVLLEPMMKVEVEVPEDFLGSIIGDLSSRRGQVEGQGVEDGTSKISAKVPLAEMFGYATELRSMTQGRGIFSMEFDNYAEVPRNVAEAIISKNQGN
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AQPC_DICDI
Sequence: MPFLHLFTPYTNADNTKLILRVNESRLRLFTRQLLAEFFGTLFVVYIVSGSTLAANFAVSDPIVRVCLICLVQGFAFAAIIWSISGISGCQLNPAVTVGCVTTGRMGILNGIAFIIFQCVGALVGAGMMKASLPTFYERDLSATTLATGVNVARGFFLEMVTTSFLVFVVLGVAVYNEWDPKISRVAPLAIGCAVIAGVGFLNLFTGGSLNPARSFGPAVFSDTWHRHYIYWFGPICGGIIAGLFWRIFLSEKVLLIDRPYTDFHRSTYGTATK
What is the function of this protein?
May form a water-specific channel.
What are the official names of this protein?
Aquaporin C, Aquaporin-like protein wacA, Water channel protein A.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNMA_DEHMB
Sequence: MSDSSELVMVAMSGGVDSSVTAMLLLEQGYNVAGVSLQLKSNNEPYGNGYNLKLINRAREVAAALNIPHYVVDLSDIFSQRVIADFCQQYSQGRTPNPCIRCNYYVKIGALLNKIQDFKADYLATGHYARIVSDENGTHLLRGADGKKDQSYFLYTLPPESLSRLMFPLGQKYKKDIVRLATNMKLPVSQKESQDVCFIPDGDYKSFLATRMGFTPGKILDTTGKILGEHQGLPLYTVGQRQGLGLASNEKLFVSDMNADANTITVAGHDQLYTSRILLSNFIWRESGIPLDTSGMIVKVRYKAAPAEVKKISQSGDFYILELASPVWAATPGQAAVIYLDDMVLGGGIIESGGDTI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y754_RICCN
Sequence: MLAIISSAKTLNFEKLAPKTELTIPMFLTLTNKLLSTLQSYSENQLSKIMNISAKLALINKERFKDFDNQESKAAIFTYAGDVFNNIHIEKLTNHALNFLQSHLLIISGLYGVLKPLDTIKPYRLEMATKLNEINLTNFWQDEVTNYINKILAKQENKYLLNLASQEYSSVINPNKLKYQLVNVHFKENRNGKLSRIGINAKKARGAMVKVIANNLIDSPELLKNFSYLGYAFSTKHSSDNELVFIKS
What are the official names of this protein?
UPF0246 protein RC0754.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: FLAB_VIBPA
Sequence: MAVNVNTNVSAMTAQRYLNNANSAQQTSMERLSSGFKINSAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSANGSNSKAERVAIQEEVTALNDELNRIAETTSFGGNKLLNGTHGAKSFQIGADNGEAVMLELKDMRSDNKMMGGVSYQAESGKGKDWNVAQGKNDLKISLTDSFGQEQEININAKAGDDIEELATYINGQTDLVKASVDQDGKLQIFAGNNKVEGEVSFSGGLSGELGLGDDKKNVTVDTIDVTSVGGAQESVAIIDAALKYVDSHRAELGAFQNRFNHAISNLDNINENVNASKSRIKDTDFAKETTAMTKSQILSQASSSILAQAKQAPNSALSLLG
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.  FlaB/D is not essential for polar flagellar synthesis and swimming motility.  Homomer of FlaB/D is not able to form a functional filament.
What are the official names of this protein?
Polar flagellin B/D.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: AROE_XANCB
Sequence: MPVSRYAVFGHPVAHSLSPAIHADFGKQTGIALDYTAIDAAPEEFTAALERFAADGGKGANVTLPLKEAAFALSASPSDRARVAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERHGLDLRGRRVLLLGAGGAARGVAPALLEAGITEMVVVNRSPERADALCDALGEPGRVVSRYLEDLRELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGATAIAFLAWARSAQCRYAIDGLGMLVEQAAESFALWHGVRPQTDPVYDALRARDAVLVSAD
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: DXS_EXIS2
Sequence: MKLTEIQDPSFLKRMSVSELELFAGDIRRFLIEELATTGGHLAPNLGVVELTLALHREFDSPNDKFVWDVGHQAYVHKILTGRAGQFDTLRQHKGLCGFPKRNESVHDVWETGHSSTSLSAAMGIAVSNELKGNDDRAIAIIGDGALTGGMALEALNHIGAEQQNVIVILNDNEMSIAPNVGAMHQMLGRIRSSRKVRYAQDELETLIKKIPLIGGKLEKGGEKLKEAVKGALVPGMFFEELGFNYYGPVDGHDLTDLIEQLNYVKKEEGPVLLHVITKKGKGYRPAEYDGIGTWHGLGPYKIESGEVIKGKSKAPSYSFTVADTLTKMAREDDKLTLITPAMSVGSKLDCFEKEFPERMFDVGIAEQHAVTFAAGQATQGMKPVVSIYSTFFQRAYDQLVHDVARQNLDVTFTIDRSGLVGADGETHQGVFDIAFMRHVPNIRIVMAKDENELQHLLYSAVKYEGPIAVRFPRGEGIGVPMDETLHEISLDTWDVEREGTDVAIMAFGPQVQDALKIAELLEGDVSVRVINARTIKPLDEKMLNALYAEGIPLVTLEEAVLKGGFGSAVLEHANEQEAFPRVKRFGIPDWYIEHGGVNELLEEIGLLPGQIAEEVRSFVNQGKKQSV
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: OSPF_SHIDY
Sequence: PQMLSANERLKNNFNILYNQIRQYPAYYFKVASNVPTYSDICQFFSVMYQGFQIVNHSGDVFIHACRENPQSKGDFVGDKFHISIAREQVPLAFQILSGLLFSEDSPIDKWKITDMNRVSQQSRVGIGAQFTLYVKSDQECSQYSALLLHKIRQFIMCLESNLLRSKIAP
What is the function of this protein?
Catalyzes the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3.  This epigenetic modification results in inhibition of the transcription of a specific subset of pro-inflammatory genes, and ultimately to a reduced immune response against the invading pathogen.  The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host (By similarity).
What are the official names of this protein?
Phosphothreonine lyase OspF, Effector protein OspF.
What is the protein family that this protein belongs to?
Belongs to the phosphothreonine lyase family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the type III secretion system (TTSS). Localizes in the nucleus of the infected cell (By similarity).
Protein: TUSD_SALPC
Sequence: MRYAIMVTGPAYGTQQASSALQFAHALLNEGHELASVFFYREGVYNANLLTSPASDEYDLVRAWQKLNTQHGVALNICVAAALRRGIIDETEAGRLALPSANLQPGFTLSGLGALAEASLTCDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYH3_HUMAN
Sequence: MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
What is the function of this protein?
Promotes guanine-nucleotide exchange on ARF1 and ARF6.  Promotes the activation of ARF factors through replacement of GDP with GTP.  Plays a role in the epithelial polarization (By similarity).
What are the official names of this protein?
Cytohesin-3, ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell junction, tight junction. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
Protein: TM169_HUMAN
Sequence: MEEPTAVEGQVQLPSPHQGSLRKAVAAALALDGESTMGHRKKKRKESRPESIIIYRSDNEKTDEEPGESEGGDQPKEEEGDDFLDYPVDDDMWNLPLDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKESSRETTPEGRMACQMGADRGPHVVLWTLICLPVVFILSFVVSFYYGTITWYNIFLVYNEERTFWHKISYCPCLVLFYPVLIMAMASSLGLYAAVVQLSWSWEAWWQAARDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISSTLSNKDPIQEVETSTV
What are the official names of this protein?
Transmembrane protein 169.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DAPD_BEII9
Sequence: MANDKLESLIEAAFEDRAQINASTQGDVRDGVERALLELDSGKLRVAEKQAGATGPDAWKVNQWLKKAVLLSFRLNDMSTIEGGPGGSSWWDKVPSKFAGWTAAEHAAAGFRSVPNCVVRRSAYIAPGVVLMPSFVNLGAYVDTGSMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDDCFIGARSEIVEGVIIGQGSVVSMGVFISSSTKIIDRATGKIHIGYVPPYSVVVSGNLPGKNLPDGTPGPSLYCAVIVKTVDAQTRSKTGINELLRD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADB_SHEHH
Sequence: MIYQSPTIEVELLEDNIAHLCFKAQGSVNKFDRETIDSLNAALDSIKQDTSIKALMLSSAKDAFIVGADITEFLGLFAEEDAVLQSWLEQANVVFNKLEDLPFPTLSAINGFALGAGCETILATDFRIADTTARIGLPETKLGIIPGFGGTVRLPRVIGADNALEWITSGKDQRPDAALKVGAIDAVVAPEQLRPAALRMLKDAMAEKLDWQTRRAKKLAPLTLPKLEAMMSFATAKGMVFKIAGKHYPAPMAVISVIEQAAQCGRAEALQIEHQAFIKLAKTEVAQALIGIFLNDQLVKGKAKKAGKLAKKVNSAAVLGAGIMGGGIAYQSASKGTPIVMKDIAQPALDLGLGEAAKLLTAQVKRGRSTPAKMATVLNNITPALDYAPVKDTDIIVEAVVEHPKVKSMVLAEVEEHVSEDAIITSNTSTISINLLAKSLKKPERFCGMHFFNPVHKMPLVEVIRGENSSDETVASVVAYASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSGLLADGADFAAIDKVMEKQFGWPMGPAYLLDVVGLDTGHHAQAVMAEGFPDRMGKSGKDAIDVMFEAERFGQKNNKGFYQYSVDHRGKPKKDLDPTSYELLQAEFGEQKAFESDEIIARTMIPMIIETVRCLEEGIIASPAEADMGLVYGLGFPPFRGGVFRYLDTIGVANFVALADKYAHLGGLYQVTDTMRELAANNGSYYQQA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: MDTB_ECODH
Sequence: MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA
What is the function of this protein?
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGR_SHEB5
Sequence: MQTTKNQDDLVRIFKSILKEERFGSQSEIVTALQAEGFGNINQSKVSRMLSKFGAVRTRNAKQEMVYCLPAELGVPTAGSPLKNLVLDVDHNQAMIVVRTSPGAAQLIARLLDSIGKPEGILGTIAGDDTIFICPSSIQDIADTLETIKSLFNYAE
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP151_IXOPE
Sequence: MESFVAMKVVCILFLFVVAAEAASTKESPAVNPSKGKDRIKFNFPRYVPNHHVFASNLLKLCTEYTPETQARNDGSQATYKPRINDLQVNFKNCTFLCKREFGNVTLNLPVDTPCGPNKQTCADKSKCVGHIPGC
What is the function of this protein?
Salivary tick protein that downregulates host immune system by binding to both dendritic cells, and CD4(+) T cells.  Specifically binds to the CD4 coreceptor on T cells.  This interaction prevents the activation of the Src kinase, Lck, and its downstreamsubstrate Zap-70, and results in deficient activation of PLCgamma1, the repression of calcium fluxes triggered by T-cell antigen receptor (TCR) ligation, and a subsequent reduction in interleukin-2 production.  This salivary protein also binds to DC-SIGN (CD209) on dendritic cells (DC) and activates the Raf-1 kinase/MEK signaling pathway that results in down-regulating expression of pro-inflammatory cytokines.  Furthermore, it inhibits T cell proliferation induced by DCs (By similarity).  It also inhibits in vitro keratinocyte inflammation induced by Borrelia burgdorferi or by the major outer surface protein (OspC) of Borrelia.  In addition, it downregulates chemokines and monocyte chemoattractant protein 1, as well as several antimicrobial peptides such as defensins, cathelicidin, psoriasin, and RNase 7 (By similarity).  Apart from its immunomodulatory activities, it is also associated with protection of Borrelia spirochetes from antibody-mediated killing through its binding to OspC.  In vivo, tests on different immune disease animal models show promising therapeutic results, e. g. , in inhibiting HIV infection, experimental autoimmune encephalomyelitis, transplantation rejection, and asthma (By similarity).
What are the official names of this protein?
Salivary protein 15 Iper-1, Salp15 Iper-1, Salp15-like.
What is the protein family that this protein belongs to?
Belongs to the salp15 family.