PharMolix/UniProtQA huggingface dataset:
Protein: NET3_MOUSE
Sequence: MPTWLWGLLLTAGTLSAALSPGLPASADPCYDEAREPRSCIPGLVNAALGREVLASSTCGRSANRVCDSSDPQRAHSADLLTSAPGTASPLCWRSDLLQQAPFNVTLTVPLGKAFELVFVSLRFCSAPPTSVALLKSQDHGRSWVPLGFFSSSCTLDYGRLPAPADGPSGPGPEALCFPAPQAQPDGGGLLAFSVQDGSPQGLDLDNSPVLQDWVTATDIRIVLTRPAIQGDTRDGGVTVPYSYSATELQVGGRCKCNGHASRCLLDTHGHLVCDCQHGTEGPDCSRCKPFYCDRPWQRATGQEAHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRVLSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPVPGPTEESSPVEPQDCESHCRPARGSYRISLKKFCRKDYAVQVAVGARGEARGSWTRFPVAVLAVFRSGEERARRGSSALWVPTLDAACGCPRLLPGRRYLLLGGGPGAAAGSTAGRGQGLSAARGSLVLPWRDAWTRRLRRLQRRERRGRCGTA
What is the function of this protein?
Netrins control guidance of CNS commissural axons and peripheral motor axons.
What are the official names of this protein?
Netrin-3, Netrin-2-like protein.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: ILVD_SULIA
Sequence: MPAKLNSPSRYHGIYNAPHRAFLRSVGLTDEEIGKPLVAIATAWSEAGPCNFHTLALARVAKEGTKEAGLSPLAFPTMVVNDNIGMGSEGMRYSLVSRDLIADMVEAQFNAHAFDGLVGIGGCDKTTPGILMAMARLNVPSIYIYGGSAEPGYFMGKRLTIEDVHEAIGAYLAKRITENELYEIEKRAHPTLGTCSGLFTANTMGSMSEALGMALPGSASPTATSSRRVMYVRETGKALGSLIENGIKSRDILTFEAFENAITTLMAMGGSTNAVLHLLAIAYEAGVKLTLDDFNRISKRTPYIASMKPGGDYVMADLDEVGGVPVVLKKLLDAGLLHGDVLTVTGKTMKQNLEQYKYPNVPHSHIVRDVKNPIKPRGGIVILKGSLAPEGAVIKVAATNVVKFEGKAKVYNSEDDAFKGVQSGEVREGEVVIIRYEGPKGAPGMPEMLRVTAAIMGAGLNNVALVTDGRFSGATRGPMVGHVAPEAMVGGPIAIVEDGDTIVIDVESERLDLKLSEEEIKNRLKRWSPPSPRYKSGLLAKYASLVSQASMGAVTRPA
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RL101_PLAVT
Sequence: MRGAYSVITALLVVASSQIAAESDYQLQVYHHDVTVAGNAVVKSLPKRYLRGSQHVHDSNEERSVYSVLASMINEGVSKMPQAAEAVEKMPQAAEAVKKMPHAATAGKKVSRVTRTGKKMTSHGANARKGPLRADFVEKMPHAAEAKEEMQRANQHDLLKAIHQADEALEKSWHPSSDTAAIRYASHGISSNVILTLKEWRKNFRGMREMAVSSEHKDIIKPIHKAFVRLCGENMDPTTIEMSHIWNMMDWNVAASPATSHRQNLVSQAQRYVLIGLRSMKKDPAVWKEWNKLSKSLRFGVLDYLLNLHYQRWVRMYNIFKRHRPDKWDVPMNDKLSLDGNTDTNSALALQTHSNKQSLYPNEPSNAAWTSKGDRFVSSKRSRRTFNGNTDTASLPSKRSKVRSSKSFVPLSTESTTFGDHSVSTKTSRVSAVAPPKRPKAHNLDVLASAATALALKDSEFVMHES
What is the function of this protein?
Secreted effector that partially suppresses the host cell death induced by cell death-inducing proteins.
What are the official names of this protein?
Secreted RxLR effector protein 101.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: C_SENDF
Sequence: MASATLTAWIKMPSFLKKILKLRGRRQEEESRSRMLSDSSMLSCRVNQLTSEGTEAGSTTPSTLPKDQALPIEPKVRAKEKSQHRRPKIIDQVRRVESLGEQASQRQKHMLETLINKIYTGPLGEELVQTLYLRIWAMEETPESLKIPQMREDIRDQVLKMKTERWLRTLIRGEKTKLKDFQKRYEEVHPYLMKEKVEQVIMEEAWSLAAHIVQE
What is the function of this protein?
The different products prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways.  They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2.  Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cytoplasm.  They inhibit IFN-gamma induced serine phosphorylation of STAT1.  Block the IFN-gamma pathway by binding to and stabilizing the parallel form of the STAT1 dimer, further inducing high-molecular-weight complex formation and inhibition of transcription by IFN-gamma.  May also have a role in preventing the cell to enter apoptosis.  Modulate regulation of viral transcription and replication.  Overexpression inhibits the viral RNA polymerase.  The absence of all C', C, Y1 and Y2 proteins leads to viral delayed growth.  Plays an important role in virion particles release.  Modulates virion shape.
What are the official names of this protein?
Protein C'.
What is the protein family that this protein belongs to?
Belongs to the respirovirus protein C family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Protein C' seems to localize around the Golgi.
Protein: V018_FOWPN
Sequence: MNSYIKNHCYLCITQEKIMTLTYKYSTMDRLLSLHNILKENNVDRLRELIESDKDVINMYDSNRLLPLHIAIEHSDIEIVEMLLDNNAVINGGETIKTHPINIAMILAGGRMMLYNDNKPVKPSKRIRRLLTVNNTEKYTKIVKLLIKHGADLKMVCRSYVLDFYKGGSYCIKTGYAIGYSYFSTIPLCQILWEETKHPSLYYMRRITIKCAIRAVNIELVKHFISNNLLADTDTALEDYFLEAVKTNSPKMVKLFLDSGIDINSTICENSHTALYHAVEQENVTLVMLLLNHGADPDIGDIYSMLKYAIMSSKHGVKLFNILVKNGARIRCCNDILIEAICKRYYSIISYILSLPVNYLPISILCMCIYELRNLPITRKLLKKINDINVSCDACNMYPIHAAVSINTSRLTRLLINKGADVNVRNRYGKTPIHLACMYSKIGNIKVLIKNGANVNERDNYGITPLMICSREGKVSNMEYLLANGADVNQTDYDKNTALTYAIRNKSKECTRVLLEHGADMCFMNRFHTPITIHKTHDNPAVFLAVIYLYFSVINDSSIRNKQGFVRNMRFVNNHKETKSLKDEIENELSIMKDNVFYTGDKKISLYDVLILDKLDDLANTIKRIRRIDLKQIIIFRRFIKKHIKYMEKRNSAIESVLSIINEYTSKDHLSRWWLLSPEIHRVIVSNLSMEDLKTISGYY
What are the official names of this protein?
Putative ankyrin repeat protein FPV018.
Protein: NPL42_ARATH
Sequence: MMMLRIRSRDGLERVTAEGAHITVSQLKTLIADQLQIPLHKQTLSTNRDLLLAKTPADLLAFTDLTDPNLPLSSLNLGHGSMLYLAYDGERSIPGAPPVTPAGSFGRKMTVDDLIARQMRVTRQETSHCDSVSFDRDAANAFQHYVNESLAFAVKRGGFMYGTVTEEGQVEVDFIYEPPQQGTEANLILMRDADEEKRVDAIAMGLGMRRVGFIFNQTVVQDKTEYTLSNAEVLQAAELHAESELKEWVTAVVKLEVNEDGGADVHFEAFQMSDMCIRLFKEEWFETEIMPDDDPKLSKMKKEVVVGVKDLKEVDNDFFLVLVRILDHQGPLSSTFPIENRSSRATMRALKTHLDRAKSLPLVKKMSDFHLLLFVAQFLDVSSDVPALAECVRLQSPVPEGYALLIESMANTC
What is the function of this protein?
May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
What are the official names of this protein?
NPL4-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the NPL4 family.
Protein: COAE_SHIDS
Sequence: MRYIVALTGGIGSGKSTVANAFADLGINVIDADIIARQVVEPGAPALHAIADHFGANMIAADGTLQRRALRERIFANPEEKNWLNALLHPLIQQETQHQIQQATSPYVLWVVPLLVENSLYKKANRVLVVDVSPETQLKRTMQRDDVTREHVEQILAAQATREARLAVADDVIDNNGAPDAIASDVARLHAHYLQLASQFVSQEKP
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP1_ROTW3
Sequence: MATFKDACYHYKKLNKLNSLVLKLGANDEWRPAPVTKYKGWCLDCCQYTNLTYCRGCALYHVCQWCSQYNRCFLDEEPHLLRMRTFKDVVTKEDIEGLLTMYETLFPINEKLVNKFINSVKQRKCRNEYLLEWYNHLLMPITLQALTINLEDNVYYIFGYYDCMEHENQTPFQFINLLEKYDKLLLDDRNFHRMSHLPVILQQEYALRYFSKSRFLSKGKKRLSRSDFSDSLMEDRHSPTSLMQVVRNCISIHINDCEWNKACTLIVDARNYISIMNSSYTEHYSVSQRCKLFTKYKFGIVSRLVKPNYIFSSHESCALNVHNCKWCQINNHYKVWEDFRLRKIYNNVMDFIRALVKSNGNVGHCSSQESVYKYIPDLFLICKTEKWNEAVEMLFNYLEPVDINGTEYVLLDYEVNWEVRGLVMQNMDGKVPRILNMNDTKKILSAMIFDWFDTRYMRETPMTTSTTNQLRTLNKRNELIDEYDLELSDVE
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7.  Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.
What are the official names of this protein?
Non-structural protein 1, NSP1, NCVP2, Non-structural RNA-binding protein 53, NS53.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP1 family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton.
Protein: IF2G_THEKO
Sequence: MAKKKEFRQAEVNIGMVGHVDHGKTTLTKALTGIWTDTHSEELRRGITIKIGFADAEIRKCPHCGKYSTSPVCPYCGHETEFERRVSFIDAPGHEALMTTMLAGASLMDGAVLVIAANEGVMPQTREHLMALQIVGNRNIVIALNKIELVDREKVMERYQEIKEFVKGTVAENAPIIPISALHGANVDVLLAAIEEFIPTPKRDPNKPPKMLVLRSFDVNKPGTPPEKLVGGVIGGSIVQGKLRVGDEIEIRPGVPYEEHGRIKYEPITTEITSLQAGGRFVEEAYPGGLVGVGTKLDPFLTKGDLMAGNVVGKPGQLPPVWDELTLEVHLLERVVGTEEELRVEPIKRREVLLLNVGTARTMGLVTGLGKDTVELKLQIPVCAEVGDRVAISRQVGSRWRLIGYGFIRE
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit gamma, aIF2-gamma, eIF-2-gamma.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: PQQB_PSEAE
Sequence: MHIRILGSAAGGGFPQWNCNCRNCRGVRDGSVAAQPRTQSSIALSDDGERWILCNASPDIRAQIAAFPALQPARRPRDTAIGAIVLLDSQIDHTTGLLSLREGCPHEVWCTQMVHQDLSEGFPLFPMLSHWNGGLRHRPIALDGEPFAIPACPRLRFTAIPLRSSAPPYSPHRGDPHPGDNIGLFVEDLDSAGALFYAPGLGEVDEALLEWMRRADCLLVDGTLWRDDEMLVCEVGDKLGRQMGHLAQSGPGGMLEVLAKVPAARKVLIHINNTNPILDTASAERAELDASGIEVAWDGMHIQL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.
Protein: CB2A_PYRPY
Sequence: MATTMASCGIGSRCAFAGAQLSSVKPQNNQLLGVGGAHGEARLTMRKATGRKSVAASIDSPWYGPDRVMYLGPFSGEPPSYLTGEFPGDYGWDTAGLSADPETFAKNRELEVIHSRWAMLGALGCVFPELLARNGVKFGEAVWFKAGAQIFSEGGLDYLGSPQLIHAQSILAIWACQVILMGAIEGYRVAGGPLGEVTDPIYPGGNFDPLGLADDPDAFADVKVKEIKNGRLAMFSMFGFFVQAIVTGKGPIENLADHLADPVNNNAWAYATNFVPGK
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
What are the official names of this protein?
Chlorophyll a-b binding protein 1A, chloroplastic, LHCII type II CAB-1A, LHCP.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: CC146_HUMAN
Sequence: MEDSSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGVYTTAEQRPNAYIPEADATLPLPKPYGALAPFKPSEPGANMRHIRKPVIKPVEI
What are the official names of this protein?
Coiled-coil domain-containing protein 146.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to only one centriole identified as the mother centriole by co-staining with CEP164.
Protein: RSL2_ARATH
Sequence: MEAMGEWSNNLGGMYTYATEEADFMNQLLASYDHPGTGSSSGAAASGDHQGLYWNLGSHHNHLSLVSEAGSFCFSQESSSYSAGNSGYYTVVPPTVEENQNETMDFGMEDVTINTNSYLVGEETSECDVEKYSSGKTLMPLETVVENHDDEESLLQSEISVTTTKSLTGSKKRSRATSTDKNKRARVNKRAQKNVEMSGDNNEGEEEEGETKLKKRKNGAMMSRQNSSTTFCTEEESNCADQDGGGEDSSSKEDDPSKALNLNGKTRASRGAATDPQSLYARKRRERINERLRILQNLVPNGTKVDISTMLEEAVHYVKFLQLQIKLLSSDDLWMYAPIAFNGMDIGLSSPR
What is the function of this protein?
Transcription factor involved in the regulation of root hair elongation (PubMed:20139979, PubMed:27452638).  Does not seem to be a direct transcriptional target of RHD6 and RSL1 (PubMed:20139979).  Involved in the regulation of root hair elongation in response to low phosphate (PubMed:29651114).
What are the official names of this protein?
Transcription factor RSL2, Basic helix-loop-helix protein 85, AtbHLH85, bHLH 85, Protein ROOT HAIR DEFECTIVE 6-LIKE 2, Protein RHD SIX-LIKE 2, Transcription factor EN 115, Transcription factor bHLH85, bHLH transcription factor bHLH085.
What are the subcellular locations of this protein?
Nucleus.
Protein: UVRC_ECO55
Sequence: MSDQFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQQIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVEGLVSEEEYAQQVEYVRLFLSGKDDQVLTQLISRMETASQNLEFEEAARIRDQIQAVRRVTEKQFVSNTGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELSEVVETFVGQFYLQGSQMRTLPGEILLDFNLSDKTLLADSLSELAGRKINVQTKPRGDRARYLKLARTNAATALTSKLSQQSTVHQRLTALASVLKLPEVKRMECFDISHTMGEQTVASCVVFDANGPLRAEYRRYNITGITPGDDYAAMNQVLRRRYGKAIDDSKIPDVILIDGGKGQLAQAKNVFAELDVSWDKNHPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSSLETIEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUFE_SHIFL
Sequence: MALLPDKEKLLRNFLRCANWEEKYLYIIELGQRLPELRAEDGSPQNSIQGCQSQVWIVMRQNAQGIIELQGDSDAAIVKGLIAVVFILYDQMTPQDIVNFDVRPWFEKMALTQHLTPSRSQGLEAMIRAIRAKAAALS
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_PROMP
Sequence: MAYSKNFSIEELRFDNKGLIPAIAQDWLDGSILMLAWMNKESLNKTLETRNVHYWSRSRSEIWRKGATSGSTQFLKEIRFDCDNDALVLSIEQNGSGACHTGEKSCFFNEIDSISMNKTAKKTSPFSNICSELFDTLHERSINPLEKSYTNHLLTKGSNTILKKIGEETAEFIMACKDNDKDEIANEASDIIYHLQVALIYKGVKWRDVLNVLESRRGKNN
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisIE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUT9_MOUSE
Sequence: MTSTSKGILRPFLIVCIILGCFMACLLIYIKPTNSWVFSPMESASSVLKMKNFFSTKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDFNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN
What is the function of this protein?
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth (PubMed:12626397, PubMed:9756916, PubMed:15121843, PubMed:16973732).  Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis (By similarity).  Furthermore, it is capable of synthesizing Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis (By similarity).  May also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.
What are the official names of this protein?
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9, Fucosyltransferase 9, Fucosyltransferase IX, Fuc-TIX, FucT-IX, Galactoside 3-L-fucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Golgi apparatus membrane.
Protein: ACTG_CHICK
Sequence: MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, cytoplasmic 2, Gamma-actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HIS4_FRAP2
Sequence: MNIFPAIDLINGKCVRLEKGDFNKTTTYELEPKDVAKAYQQAGAEFIHVVDLDGAKKGQTCQFETIQKIRENCNMTLQVGGGVKDFETIEKLLEIGVDRVVIGSLAVKDIALTKKFFEKYGAEKIVLALDVFIKNGVPYIATHGWQESSTTTLDEILQTYLGDGLEYVLCTDISRDGMLQGPNFELYRIYSSIYPDVQFMASGGVGSLEDLEILKEQNTYGVIIGKALYENKFTLQEALEC
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPPK_MYCTU
Sequence: MRRNIRVTLGAATIVAALGLSGCSHPEFKRSSPPAPSLPPVTSSPLEAAPITPLPAPEALIDVLSRLADPAVPGTNKVQLIEGATPENAAALDRFTTALRDGSYLPMTFAANDIAWSDNKPSDVMATVVVTTAHPDNREFTFPMEFVSFKGGWQLSRQTAEMLLAMGNSPDSTPSATSPAPAPSPTPPG
What are the official names of this protein?
Putative lipoprotein LppK.
What is the protein family that this protein belongs to?
Belongs to the MTB12 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: SOK3_PHYPA
Sequence: MARGEDSSSVQVLYQLSWDGKLEHPHMIEVHYPPNQGGLRLRDVKKRLTTLRGHGINDSFSWSSKRNYKNEFIWNDLCDDDVIQPLRGSGEYVLRASELFDTFTNKPWEHPSKHSNERMQSSRTMSVDNVTLQQGLINVKLHSGALAREDDQPSGEKLCCSGRRSCINLEDCSSKGVAIDIPKNLQNLSVDQETIDVEKSDFCLSSSDNEVSPRLKTAADCITPVKDVGLVVMTRSTTVHGLHTPAPRSLTSPTEPPFSPGSAKRMWKKEIRKSLFRTSRNSSNVNPVLSGENAALDVDVPPITLSTQEDVSFWRDGRSKSASPSSLNELREVQNEKEKEAEQSTSQLIRLLWARWTGGSSKGKRTPQSTCEDPLPKSPEAKQMPRSRTKTPCKEIRSTNHIAGSLPVTCPSPAVDNKAHSSLDRQEIPPQEECKNRPSPMTLQSCEEITSPVTEIEQDVEIGDIKAIVEEQASNKFPEPEFQQNLRTEQIVLSVQIPDLHIDALDSPTSDTQGSPAEADIPKSATARVKTSNSLPRVKTTTSPKPLPPGFHKGTNDTKPVQIITPRRTPRTSIPLASPPPLVRTFNRVSVRSLSSIAAITLSPENDSAASNLSPENPIVKKRINFRERDEMPLIPGLTTLDWEKALQEAVTDCLPPPNFREILQECSTCGRTFKPDSLQVHMRGCHPPQYARAFSARASPHVVRSRAS
What is the function of this protein?
SOSEKI proteins locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes.
What are the official names of this protein?
Protein SOSEKI 3, PpSOK3.
What is the protein family that this protein belongs to?
Belongs to the SOSEKI family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NS1_BRSVA
Sequence: MGSETLSVIQVRLRNIYDNDKVALLKITCHTNRLILLTHTLAKSVIHTIKLSGIVFIHIITSSDYCPTSDIINSANFTSMPILQNGGYIWELMELTHCFQTNGLIDDNCEITFSKRLSDSELAKYSNQLSTLLGLN
What is the function of this protein?
Plays a major role in antagonizing the type I IFN-mediated antiviral response by degrading or inhibiting multiple cellular factors required for either IFN induction or response pathways.  Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3.  Also disrupts the association of IRF3 with CREBBP.  Interacts with host mitochondrial-associated membrane (MAM) MAVS and prevents the interaction with RIGI.  Interacts with TRIM25 to suppress TRIM25-mediated RIGI ubiquitination and thereby RIGI-MAVS interaction.  Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C.  The degradasome requires an intact mitochondrial MAVS.  Decreases the levels of host TRAF3 and IKBKE/IKK-epsilon.  As functions other than disruptions of the type I IFN-mediated antiviral signaling pathways, induces host SOCS1 and SOCS3 expression.  Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth.  Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication.  Suppresses proliferation and activation of host CD103+ CD8+ cytotoxic T-lymphocytes and Th17 helper T-lymphocytes.
What are the official names of this protein?
Non-structural protein 1, Non-structural protein 1C.
What is the protein family that this protein belongs to?
Belongs to the pneumovirus non-structural protein 1 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host mitochondrion. Host nucleus. Note=Most NS1 resides in the mitochondria as a heteromer with NS2.
Protein: ATPF_VIBAL
Sequence: MNINATLLGQAISFALFVWFCMKYVWPPLMKAIEERQKKIADGLQAAERAAKDLDLAQANASDQLKEAKRTATEIIEQANKRKSQILDEAREEAQAERQKILAQAEAELEAERNRARDDLRKQVATLAVAGAEKILERSIDKDAQKDILDNITAKL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PA2PA_OXYMI
Sequence: MHPAHLLVLLAVCVSLLGASDIPPLPLNLAQFGFMIKCANHRSRPVSHYMDYGCYCGKGGSGTPVDELDRCCQVHDECYGEAEKRFKCVPYMTLYSWKCYGTAPSCNTKTDCQRFVCNCDAKAAECFARSPYQNKNWNINTKARCK
What is the function of this protein?
Monomer (alpha chain): Snake venom phospholipase A2 (PLA2) alpha chain that possesses the same high enzymatic activity than the heterotrimer.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
What are the official names of this protein?
Basic phospholipase A2 paradoxin-like alpha chain, svPLA2, PLA-4, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.