PharMolix/UniProtQA huggingface dataset:
Protein: UBQLN_HUMAN
Sequence: MWHAISRTSRMSQSGCPSGLLADKNISSSATRVIVKTAGNQKDFMVADDISVRQFKEMLLAHFQCQMDQLVLVFMGCLLKDHDTLSQRGIMDGHTIYLVIKSKQGSRSLAHSFRDLPTNDPCHRDRNTKGNSSRVHQPTGMNQAPVELAHFVGSDAPKVHTQNLEVSHPECKAQMLENPSIQRLLSNMEFMWQFISEHLDTQQLMQQNPEVSRLLLDNSEILLQTLELARNLAMIQEIMQIQQPSQNLEYPLNPQPYLGLETMPGGNNALGQNYADINDQMLNSMQDPFGGNPFTALLAGQVLEQVQSSPPPPPPSQEQQDQLTQHPATRVIYNSSGGFSSNTSANDTLNKVNHTSKANTAMISTKGQSHICATRQPAWIPALPSIELTQQLQEEYKDATVSLSSSRQTLKGDLQLSDEQSSSQITGGMMQLLMNNPYLAAQIMLFTSMPQLSEQWRQQLPTFLQQTQISDLLSA
What are the official names of this protein?
Ubiquilin-like protein.
Protein: BOD1_RAT
Sequence: MADSAGAGAAGQASGPAGGSSGAGGTVNPASLPPGDPQLIALIVEQLKSRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPAMNKNQLRNGLRQSVVQSGMLEAGVDRIISQVVDPKLNHIFRPQIERAIHEFLAAQKKEAVPAPPPEPEGQDPPAPSQDAS
What is the function of this protein?
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
What are the official names of this protein?
Biorientation of chromosomes in cell division protein 1, Biorientation defective protein 1, Protein FAM44B.
What is the protein family that this protein belongs to?
Belongs to the BOD1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.
Protein: HOKB_ECOLI
Sequence: MKHNPLVVCLLIICITILTFTLLTRQTLYELRFRDGDKEVAALMACTSR
What is the function of this protein?
Toxic component of a type I toxin-antitoxin (TA) system (Probable).  When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration (PubMed:10361310).  Expression leads to membrane depolarization; when protein levels are high enough depolarization probably leads to lowered metabolic activity which in turn induces some cells to enter the persistent state in which they transiently survive antibiotic exposure.  Its toxic effect is probably neutralized by antisense antitoxin RNA SokB, which is encoded in trans on the opposite DNA strand (PubMed:10361310).
What are the official names of this protein?
Toxic protein HokB.
What is the protein family that this protein belongs to?
Belongs to the Hok/Gef family.
What are the subcellular locations of this protein?
Cell inner membrane; Single- pass membrane protein.
Protein: GACT_DICDI
Sequence: MKNIFRRSVQIFHKDKKEGDKQDYTGSSGSSGNSGTDRSPTSSLSKKDKKHSKHHQNESYSGDNSPTLSRNHHDEIGHLQYTANHHIATSHHSHSHNHNHNHNHQLTQPIQQQQQTQHVNLASNNYYIRHIYTNNQYDETTQIVMNNGIPFIYNPNARKIFGVPLTQVPCRAGSNVPIIIEKLIDHIERTSLNSEGLFRIPGVDLTINQYIKLFDNGEDVDVSPIEPYTAAGLLKRFFRDLPVFVPQSINKRVVSLFIDEEGKKKPVDMEILSNLRVLVHQLPTVHFEVMQELTNLLGKLMSRSDQNKMTISNIAICLVPTLNCVPAIVTYSIQMHDFFYNEVFPQHHLYYMRPYEEKLVESAPTQPINIMTTSGGEKRYSSRPASITISGLLPSNGQNNSPSSSTITSTTITSPHDSTAPITFTVTTTFSPEQQQQMLQQQQQQQQQQEKQSSSSLSQSQQSIQPISDTNSTKSDRRTFRVDPNLDLTQYIEDTQYNVNRNYLYNGGPSGTTGTTPNGGSLSIGGGNGGNGGSSLSVGSGGGNGGSSLSVGSNTSVGVGGGGGGNNTTDQSKIYRRSVAYTNNEDTKAAIQQIKEKIDRYSKEKKTREEKEREKLLRYSIDLERYKDRTINNKQEKRASRDINKEIEREIEKKRLSPRERLNLFGLSSSSSSVNSTLTRSTANIISTIDGSGGSNRNSKNYGNGSSSSSNRRYSNTINQQLQMQLQQLQIQQQQYQQTQQSQIPLQYQQQQQQQQQQTTTTTTTSSGSNRFSSNRYKPVDLTQSSSNFRYSREIYDDDYYSNNNLMMFGNEQPNQTPISVSSSSAFTRQRSQSCFEPENLVLLQQQYQQYQQQQQQQQQIPFQANPQYSNAVIEQKLDQIRDTINNLHRDNRVSRDYTHYLREVEDLRSSLQKETVVSNEFIKNIELEDKLRREEEKNQRLIEEIHLLETYFILKEKSKAKRLSTTKDLLTRSRSPTLPSSINMSTSSLGSSSSSAYNNNNNNNNVPK
What is the function of this protein?
Rho GTPase-activating protein involved in the signal transduction pathway.
What are the official names of this protein?
Rho GTPase-activating protein gacT, GTPase activating factor for raC protein T.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MKK5_LEIME
Sequence: MSRLKINLDAIERDGASATEGFCADGVRIGSLLVSSEGVRDNQGNLCVLSLSDLEVVPETEGGFLGKGSSGSVRRAVHRGSNKVVALKEIKVTGQTHINEIRRELETLHAGDFATPYLVSFYGAFAHEGSVFIAMEAMDGSLHELYKPVPPPVLACITRLMLKGLTYLHRNRHLIHRDLKPSNVLYNSRTGDIKISDFGVSSNLECTKADAHSFVGTVTYMSPERLRGEHYSYGADIWSLGLVVAELAVGVCPYAGLRGGSSEARFWALLQHLNGDGTALELPPEMDSDLADFISACVVKSPDRRPTCTELLRHPFIVRYTGAAPEAEAKPFSTTTPTVLAPGGLSSLLNRASPAAGSALPLASEGGTPKATSPSPAPVSPLTLSCPLERHDGETDADIADRTVVARWIHAVMKRAVLHKARGHGREELHQEPLAAVSASVATDSGEGGGAAGVSAASLDNGQAAQHREFRAERNLDGHSGDGGSAPVEEDCTAGVRSLTCDDLRWTSTGEPSVNLDDELNRLLF
What is the function of this protein?
Protein kinase which phosphorylates and activates MPK4 in vitro.
What are the official names of this protein?
Mitogen-activated protein kinase kinase 5, LmxMKK5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Protein: NIKR_ECOL6
Sequence: MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel (By similarity).
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: DNLJ_PSEU2
Sequence: MKAVETRILELRAELDQHNYRYHVLDEPSIPDVEYDRLFHELKALEAENPHLVTPDSPTQRVGSAALSAFTQVRHEMPMLSLGNAFEENDMLEFDRRVTEGLDLPAGDLFGEGGKVQYSCEPKLDGLAVSLLYRDGALVRGATRGDGTTGEDISVNVRTVRNIPLKLQGKGWPDVLEVRGEVFMSKAGFERLNASQLEIGGKTFANPRNAAAGSLRQLDSKITANRPLEFCCYGLGQTSAEIADTHIGVLEALKKWGMPVSRELKLANGVEECLAYYRDIGERRLTLTYEIDGVVFKVNNLAAQRELGFRAREPRWAIAHKFPAMEELTELLDVEFQVGRTGAVTPVARLKPVKVAGVMVANATLHNMDEVARLGLMIGDTVIIRRAGDVIPQVVQVVAERRPENARAVQVPQTCPVCGSHVERTQLIKRSKGKETVTEGAVYRCVGRLACGAQLKQAIIHYVSRRAMDIEGLGDKTIEQLVDEKLIGSPADLYKLKYEQIIDLEGFAEISSNKLLKAIADSRQPTLARFIYALGIPDVGEETAKVLARSLASLERVKQALPEVLTYLPDVGLEVAYEIRSFFEDEHNRSVIDALLGECGLQLQDQGELGAEFAASTTLEGLIDKLHIPSVGPGAAQKLADRFGTLEAIISADWLDMRQALPEKQAKSVRDFFDDSANAERARAIEAQLKDFGMHWRSEKKTVEGLPLAGQTWVLTGSLERMSRDVAKEKLESLGAKVSGSVSAKTHTVVAGPGAGSKLTKANELGLTVLDEDALLKRLIELGVAVD
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: TOPZ1_CALJA
Sequence: MRRHPPLDPTMAPGPEDNVRNLRKRQARGPGTARGCGPEVGGRRKNRQKRRMVAQASPGKDKVERDRSVAASGAEKATRRRVERPRGQVSPSDRRGIQAAKEAELRLQTERHTKEKRKVTEASSDDPQPEIDLVRKESLTSSESFQTVECLQSLSKEGIVEGIKRRRIRNKKLKSLENPPLKVTENEATQNIKVEFQDELYKNTPKYSCNILSPEVENNSILKLHVCNCFPHSKGCNDENNLPYKPDGGCMHVAENSSKLKKENLRSLAEKSDTNSIPRLLQTKESVMGVNKLLLEESDLCQSKTNDLLSCLQREKNKYSIEESSVGRKSRKRIKSEKAVTESETVTEMNFYEYNKSELMLQENKMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSLPEMVGKETSPEHHVNAVCQKTIEPLLKEETENASEPLGYESMAQTEDFKSMKSSIGKSPNEYHIEKRSSQEELRRESEELKLSCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLPGSQESCRQDDVLKHQTNQTHLTDSKLLLQSSLTETNIESSSKEKLDSNSNCLSSVSAIEHTLMVMKEPIIEDDKKIKSEELSKSGSEVVSNTTEDTQLISETQILTGNKKKDRGNLTKLNLIATSKDGQEANNSTGRTIHRKSCVAKQTFVAPDLVKILNTGRLTNFKIPLLKNKTEKRKEINAKSSEREAYSPLELLDNLSGAEVRQNRSKESVSMTTSGPQTLSIQNSVTPAQASSDSFYDKNSCSIYPRFTKQDNNNKPSNHISERGNIVSNKEVASLTVENNTFSYDPGYVEKNSFFSCNEQETFQPVSSEVSVRKITKNFSEIKVGSPDILKAYEDDVLLIDVIQDDPDLFGVSNEGELSCTSGVSRISQEPNVAGEDQSADFKYMETPVKKEPSDNLRELSVLDTGSIKSEACASNSAASEIRHDSKDVNTSLGKVANKASENETLEDFSEQIKGSNLDKKHRFTDKVIIKEEKEKIYEVCKSKDSRNADIMVDECQFAAPVPKPLCLLVPPLNLSGHQEETVLNTWTNDFRFLGKHSVLKLQNPATCEIFKREKNVGVLQKSLGLMLPYKYCRFHFNTLRGCERPLCKFVHVPEQGDEKVCMDVFKKYININELCLLQRAVNIFMEYYRKFPPGIHFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKIQPSLKILLNIFEHVATMKLRNAVPALTDIFCKLIEAGMVLDPEHFNYIVKLLYQVQASKQEITAVLEMRSRLQTRLFKKNWKCDLDSALNKLEHCKEKGDWTRLGKLYLNVKMGCEKLADFETFCACIAKTLTKHYEKEGPDVPFCEFAETVSKDPQNSKVDESVLGRIGISALFFYHKLLQWSKGRKVLDKLYELKIHFTSLKGLIGPEMLASRCQIVNVAAEIFLKSGSLNGAIWVMRESEWIINTPLWPCDRLDVLNRHNLLCTIAHDILAKSLFRQAFEVLQNLPGFQNSQETVEVSQYSILFNKLLDSCIESNSLGTSSSVAEFMISKSVPIDFSFLRRLITSLGRSCLWLKARAHYKSALSLGCYPQLEGNLYRKLLLIPSYLSEIEMLLAMEIFMVSNASSIQSPGTSTQILQIVLKRCENNQSQRNDDYQAAVERLIMAARISDPKLFIKHMTVNINKEQVYSLEHCSVLKWLKENMKWAGKVWLFSNH
What is the function of this protein?
Important for normal spermatogenesis and male fertility.  Specifically required for progression to the post-meiotic stages of spermatocyte development.  Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
What are the official names of this protein?
Protein TOPAZ1, Testis- and ovary-specific PAZ domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PG121_VACCW
Sequence: MGITMDEEVIFETPRELISIKRIKDIPRSKDTHVFAACITSDGYPLIGARRTSFAFQAILSQQNSDSIFRVSTKLLRFMYYNELREIFRRLRKGSINNIDPHFEELILLGGKLDKKESIKDCLRRELKEESDERITVKEFGNVILKLTTRDKLFNKVYIGYCMACFINQSLEDLSHTSIYNVEIRKIKSLNDCINDDKYEYLSYIYNMLVNSK
What is the function of this protein?
Decapping enzyme that remove the protective 5'-cap from both host and viral mRNAs to commit transcripts for decay by the cellular exonuclease XRN1 (PubMed:17881455, PubMed:35290794).  Accelerates viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins.  Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis.
What are the official names of this protein?
mRNA-decapping protein OPG121.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: POLG_NIGSP
Sequence: SGNEDAGNVKPAAGTKENKSDKEKDKPESGNAANAKATSNTKEDGGESGTKPTTANKDKDVDVGSTGTFVIPKLKKVSPKMRLPMVSNKAILNLDHLIQYKPDQRDISNARATHTQFQFWYNRIKKEYDVDDEQMRILMNGLMVWCIENGTSPDINGYWTMVDGNNQSEFPLKPIVENAKPTLRQCMMHFSDAAEAYIEMRNLDEPYMPRYGLLRNLNDKSLARYAFDFYEINSRTPNRAREAHAQMKAAAIRGSTNHMFGLDGNVGESSENTERHTAADVSRNVHTYRGAKI
What is the function of this protein?
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae genome polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein]: Virion.
Protein: TATA_PARPJ
Sequence: MGSLSIWHWLIVLLIVALVFGTKKLRNIGGDLGGAVKGFKEGMKEADAPAAEAQQRELPRNGAVDVEAKEKTPRSGDYR
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LPOA_VIBCM
Sequence: MAMNHHQRRSVPRLLTPIALSIVLSACSTQPSSPDVVDITAQPLLTAQTYLMRADASQGNQQNDWLIMALKAAIEENNPDQAQLLIMRLAKQPLTPTQQAQWQLLRAQLLANTEQYQEALEQLSFQANWSLPQVQWQQYHQLRADIFTALDRSFDSTRELVALYGLSSNKDKEALADQIWANLNHYSASKIIKLSTEPDEAQLDGWLQLAIYMKTLGSDLPQLKNTLEKWLAENPQHPAAIYTPKAITDILALEIVKPTNTALLLPLTGKFAKQAQFIRDGFVFAMMNDADRQTNATLTIIDTNAETLESVDAILTSKQIDFVVGPLIKGNIEKLQQFQQSRGQMIPTLALNIPDQIDTTAGACYLALSPEQEVAQAAKHLFTQGYRYPLILAPQNAYGERVVEAFNEEWRRYSKNKVAVNLFGDKRQLQRNINSIFGLQDSQQNIAQMESLLGMGLESQPRSRRDIDAVYIVANSSELTLIKPFIEVAINPDTRPPKLFSNSNSNTGGRQYEDLSGVTYSDIPLLIQPAPSIKEQLTQIWPESSNAERRLQALGMDAYRLMVELPQMKIVEGYTIDGQTGVLSIDEQCVVQREISWAEHGVR
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
What are the official names of this protein?
Penicillin-binding protein activator LpoA, PBP activator LpoA.
What is the protein family that this protein belongs to?
Belongs to the LpoA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: TAP_MYCBP
Sequence: MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ
What is the function of this protein?
Efflux pump that contributes to intrinsic antibiotic resistance.  The pump uses the electrochemical gradient as a source of energy.  Confers resistance to various antibiotics, including tetracycline, acriflavine, spectinomycin and p-aminosalicylate.  May be involved in export of toxic by-products that accumulate during stationary phase when nutrients are limited.
What are the official names of this protein?
Multidrug efflux pump Tap.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Drug:H(+) antiporter-3 (DHA3) (TC 2.A.1.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RTL2_ORYSJ
Sequence: MAPPPAMKPASRKRGPPAPDPVELPPPGFVADRAEAAARVERLLRYQFRDGRLLEEALTHQSFADDAVSYQRLEFVGDSALGLAFSNFLYLTNPTLGPGPLSTLRAANISTEKLARVAVRHDLYPLLRRNCPRLDLLVGQFIETVKQEPEDDLSTVPYGGSVVKAPKVLADIVEAIAAAVYVDCKFDLEKLWKVTRWLFEPIITAETIDEQPVTMLHELCQKHGKMAQFKTWQKGGMTVVNVFVAGELVGIGSSEQKVIAKLNAARDATRKLAGAKKQVLTTGVGNGLGDEIGELRECKQKLNEQCSRQNWPKPIFK
What is the function of this protein?
Cleaves double-stranded RNA (dsRNA).
What are the official names of this protein?
Ribonuclease 3-like protein 2, Ribonuclease III-like protein 2, RNase III-like protein 2.
Protein: PEPDB_LACLA
Sequence: MKIENRRKGSCTTVLVGRKASIDGSTMIARNDDGHEALDPQRFIVIQPEEQPRHYKAVLSDLELDLPENPLRYTSTPNAVLKEGIWPAAGINSANVAMSATETITTNPRILGLDPYVENGMGEEDLVTLVLPYIKSAREGVERLGQLLKTYGTYEPNGIAFADKEEVWWLETIGGHHWAAVRIPDDSYVVAPNRMNIDEFKFDNDDYMCSSDLKQLIDANHLNPDFEGYESHYNLRHIFGSSSIKDSVYNNPRTWYGQNFLGNPSEDPQNQELPFICEASRKITVEDVKFVLSSHFENTKYDPYGSTNSPEERKLFRPIGINRNHSVHILQVRNNVPDELAGVQWLAFGANTFNHVVPFYTAINDTPASYRDAKGEYDPTNMYWLSATTAVLGDSNYDLFVDLRNTFELNTMAKFHEIQNETDKNFETAEDKIAYLTQANEKLAEAAFKAQTELLGRMVVLGSANMKLRFDFND
What are the official names of this protein?
Probable dipeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C69 family.
Protein: CYS3_NEUCR
Sequence: MSSADFNFGDFTTTYTSPTIPAYPDTLGQLQPIQPNPQAAYPPVSQHHASHHVQHPHQPGYVLSNPPQLSGNKRKASDAMSVPPTPGARVMSFEEASRLAAEEDKRKRNTAASARFRIKKKQREQALEKSAKEMSEKVTQLEGRIQALETENKWLKGLVTEKHGSKEDILKLLREFSAHAAKVSKDAAAAAADKAEAAADKADAERAREESSFCVSTSSPSSDESVDTDNKKRRKD
What is the function of this protein?
Turns on the expression of structural genes which encode sulfur-catabolic enzymes.  Binds to sequence elements upstream of these genes.
What are the official names of this protein?
Regulatory protein cys-3.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. GCN4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SPRC_BOVIN
Sequence: MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKDLVI
What is the function of this protein?
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines.  Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes.  There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
What are the official names of this protein?
SPARC, Basement-membrane protein 40, BM-40, Osteonectin, ON, Secreted protein acidic and rich in cysteine.
What is the protein family that this protein belongs to?
Belongs to the SPARC family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.
Protein: KDSB_ENT38
Sequence: MSFVVIIPARFASTRLPGKPLVDINGKPMIVHVLERARESGADRVIVATDHEDVARAVEAAGGEVCMTRADHQSGTERLAEVVEKCGFSDDTVIVNVQGDEPMIPAAIIRQVAENLAQRQVGMATLAVPIHHAEEAFNPNAVKVVMDAEGYALYFSRAAIPWDRDRFAASQEVIGDTFLRHLGIYGYRAGFIRRYVTWAPSPLEHIEMLEQLRVLWYGEKIHVAVAQEVPGTGVDTPEDLERVRAELH
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATAD1_XENTR
Sequence: MVHGEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMRQIGVKNVKLTEYEMSIAAHLVDPLSMLVTWSDIAGLDDVITDLKDTVILPIRKRYLFENSRLLQPPKGVLLYGPPGCGKTMIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAVKLQPSIIFIDEIDSFLRSRSSSDHEATAMMKAQFMSLWDGLDTDFNCQVIVMGATNRPQDLDTAIMRRMPTRFHINQPSLKQREAILDLILRNESVDSHVDLMEIARGSDGFSGSDLKEMCRDAALLCVRDSVNNSSEESPCEEIRPIHQQDLLRAIDKMKRSKSATNQNVLMHVSLD
What is the function of this protein?
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity).  Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity).  Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity).
What are the official names of this protein?
Outer mitochondrial transmembrane helix translocase, ATPase family AAA domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. MSP1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. Postsynaptic cell membrane; Single-pass membrane protein.
Protein: SPC25_DROPE
Sequence: MADLKASEGDLSDYYMRLKKIFSNETRLQSREASISKRSSRVHKNIISAKEAIERQERDFGKLQKVLLNRNQELERRFTLGEALAQQLEVTRQRNADMEAQLLRHTTEGRQRSNELMECMHSLKQATGTYINHEALPARLNGVSVVRADDGDIKLIPFSLDGNDADGLHTLWRSLHTRTDNNASKWRKLISDQEVAGASPVTPSGSERPKATSKHSNFMPTSIIEIDLTSPTNDAS
What is the function of this protein?
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis.  Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.  Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics.  The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
What are the official names of this protein?
Kinetochore protein Spc25.
What is the protein family that this protein belongs to?
Belongs to the SPC25 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore.
Protein: GLPK_BACAA
Sequence: MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITNQRETAVVWDKTTGKPIYNAIVWQSRQTAEICDELKEKGYSEMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLLFGTIDTWLVWKLSGGKAHVTDYSNASRTLMFNIHDLQWDDELLDMLTVPKSMLPEVRPSSEVYGETIDYHFFGQNVPIAGVAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGMRMFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAMFGVTRGTTKEHFIRATLESLAYQIKDVLCAMEADSGIELKTLRVDGGAVKNNFLMKFQSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAETSEELYAGWKKAIEATKAFK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: Y227_METJA
Sequence: MHLPNSQIYKNFGESMNPFDIMKASQIACCLEVSSFKPGNVHRNRDYRDIKYHHFINAGIAFGNVVYEAAQKDRDVGLYIKKAVIESKKWSPTNANLGIIMLHIPIAMAAGKLENFDENKLKENLKKIAENTTVEDALNVYDAINIAMAYVNKPKKGPDVTSEDAKKELIEKGLTLLDVYKISAEWDNISKEWVDNFKISFEGYNLLKKYYDELNNINLAVTKTFLNLLAKYPDTLIARKRGFETALKVSKMAEDVLNNFKEEKVKEFDKYLSKEGNKLNPGTTADLIASSLMIFILDRIDKRETILW
What are the official names of this protein?
Uncharacterized protein MJ0227.
Protein: RSMC_ECO7I
Sequence: MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARLDTAASRAHTQQFHHWQVLSRQMGDNARFSLVATANDVADCDTLIYYWPKNKPEAQFQLMNLLSLLPVGTDIFVVGENRSGVRSAEQMLADYAPLNKVDSARRCGLYFGRLEKQPVFDANKFWGEYSVDGLTVKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATLAANSVEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPDVLDETFGFHEVIAQTGRFKVYRAIMTRQAKKG
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_CITK8
Sequence: MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQLDEHHAVRTDAGMFDVSHMTIVDLRGSRTREFLRYLLANDVAKLTKTGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPYAIDITVRDDLSLIAVQGPNAQAKAATLFTEEQRKAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIAMPNEKAADFWRALVESGVKPCGLGARDTLRLEAGMNLYGQEMDEGVSPLAANMGWTIAWEPADRDFIGREALEVQREKGTEQLVGLVMTEKGVLRNELPVRFTDAQGNQLEGVITSGTFSPTLGYSIALARVPAGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: RDRP_I75A3
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAAQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLIANESGRLIDFLKDVIESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPEWFRNILSIAPIMFSNKMARLGKGYMFESKRMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFSEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.