PharMolix/UniProtQA huggingface dataset:
Protein: RPOZ_STAA2
Sequence: MLNPPLNQLTSQIKSKYLIATTAAKRAREIDEQPETELLSEYHSFKPVGRALEEIADGKIRPVISSDYYGKE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: FABPL_RHIAE
Sequence: MAFNGTWNVYAQENYENFLRTVGLPEDIIKVAKDVNPVIEIEQNGNEFVVTSKTPKQTHSNSFTVGKESEITSMDGKKIKVTVQLEGGKLICKSDKFSHIQEVNGDEMVEKITIGSSTLTRKSKRV
What is the function of this protein?
Involved in intracellular lipid transport.  Binds free fatty acids and their coenzyme A derivatives, lysophospholipids, prostaglandins, retinoids, bilirubin and some other small molecules.
What are the official names of this protein?
Fatty acid-binding protein, liver, Fatty acid-binding protein 1, Liver basic FABP, Lb-FABP, Liver-type fatty acid-binding protein, L-FABP.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_ASHGO
Sequence: MYLQRWLFSTNAKDIAILYFIFSTFCGLAGTAMSFIIRMELSAPGQQYLQGQNQLFNVLVTGHTILMVFFLVMPMLIGGFGNYYLPLMIGASDMSFARLNNISFWTLPPTLICLLTSTMVESGTGTGWTVYPPLSSIQSHSGASVDLAIFSLHLTTISSLLGTINFIVTALNMRTNGMTLHKMPLFTWSILITAVMLLMSLPVLSAGVTMLLMDRNFNTSFFEVQGGGDPILYQHLFWFFGHPEVYIMIVPTFGMMSHIVSTYSKKPVFGEISMIYTMGSISLLGFLVWSHHMYVVGLDTDTRAYFTSATMIITIPTSIKVFSWLTTIYGGSLRLTTPMLYTLSFLFLFTVGGLTGVVLANTSLDVAFHDTYYVVTHFHYVLSLGAVFSMFAGYYYWSPTVLGLNYNEKLSQIQFWLIFLGTNIIFFPMHFLGINGMPRRIPDYPDTFTGWNLVSSFGSMMTIMSLMLFTYIIYDQLMNGLTNKVNNKSINYMKTPDFIESNNIFLMNTTKSSSIEFMLNSPPTIHSFNTPTIQS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y1861_EDWI9
Sequence: MVGGMPALTHEQQQQAAERIQTLMTQGMSSGEAIAQVAAEIRASHRGEQIRVAFDEADDDEASQ
What are the official names of this protein?
UPF0181 protein NT01EI_1861.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: GLNA2_HALMT
Sequence: MSDTSTVKSQCEDQNIDLIRLLYVTPSGVIQANTVDVSEVDAAVESGVTLSEVIQVYDAFACRNRNSRFDAVGEVHLCPDPETFRPLPYADRAGAMLCNIRTLDGEPWDVDSRSSLQSVERDLRAKGLSPQVAFESEFSLFSRDGDGKINRGDEAGAYRTESIRGTHDAILHIVDALKAQGIDVKKYHPEFSPGKHEIVTGHHTGLEAADEHLLLRETVKSVAEQDGYQATFLPKPFDDGTNGCHINVSLWNGENQFFDPNHGDISETARQFIAGVLDHAPAVLALTAPTVNSYSRLQPRHGAAGYICWGWLNREALIRVPAPAQGREADSTRIEFRGADNTANPYLGLIGLLAAGNDGIERELEPPEPVSVDPCDLTDAQRTAKGIKRLPQTLGEALDALETNEVLREALGPDLFDAYVEVKRNHWKLFTESAGAWQRERLRNLY
What is the function of this protein?
Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine.  Not required for glutamine synthesis (PubMed:34439822).  Is not able to compensate for the loss of glutamine synthetase (PubMed:32296946).
What are the official names of this protein?
Gamma-glutamylputrescine synthetase, Gamma-Glu-Put synthetase, Glutamate--putrescine ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
Protein: TX32B_CYRHA
Sequence: MKLCAVIIASLLVCAAVASSSDNQKEFAQEKEMTREETQSLGEHEKDDEVTGSEERSCIEEWKTCENDCECCGMSTLCAASWVDGHQIKLCRNEGGKLKKVLHFIQKSVSKIKSCKK
What is the function of this protein?
Putative ion channel inhibitor.
What are the official names of this protein?
Hainantoxin-XV.2, HNTX-XV.2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 03 (Tx2) family. 02 subfamily. HNTX-XV sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOG_MYCTU
Sequence: MTQAADTDIRVGQPEMVTLTIDGVEISVPKGTLVIRAAELMGIQIPRFCDHPLLEPVGACRQCLVEVEGQRKPLASCTTVATDDMVVRTQLTSEIADKAQHGVMELLLINHPLDCPMCDKGGECPLQNQAMSNGRTDSRFTEAKRTFAKPINISAQVLLDRERCILCARCTRFSDQIAGDPFIDMQERGALQQVGIYADEPFESYFSGNTVQICPVGALTGTAYRFRARPFDLVSSPSVCEHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCDKGRWAFTYATQPDVITTPLIRDGGDPKGALVPTSWSHAMAVAAQGLAAARGRTGVLVGGRVTWEDAYAYAKFARITLGTNDIDFRARPHSAEEADFLAARIAGRHMAVSYADLESAPVVLLVGFEPEDESPIVFLRLRKAARRHRVPVYTIAPFATGGLHKMSGRLIKTVPGGEPAALDDLATGAVGDLLATPGAVIIVGERLATVPGGLSAAARLADTTGARLAWVPRRAGERGALEAGALPTLLPGGRPLADEVARAQVCAAWHIAELPAAAGRDADGILAAAADETLAALLVGGIEPADFADPDAVLAALDATGFVVSLELRHSTVTERADVVFPVAPTTQKAGAFVNWEGRYRTFEPALRGSTLQAGQSDHRVLDALADDMGVHLGVPTVEAAREELAALGIWDGKHAAGPHIAATGPTQPEAGEAILTGWRMLLDEGRLQDGEPYLAGTARTPVVRLSPDTAAEIGAADGEAVTVSTSRGSITLPCSVTDMPDRVVWLPLNSAGSTVHRQLRVTIGSIVKIGAGS
What is the function of this protein?
Plays a critical role in M. tuberculosis ability to inhibit apoptosis of infected macrophages; thus helps the bacterium in its struggle to resist the host immune response (PubMed:17658950).  In fact, via a NuoG-dependent mechanism, M. tuberculosis can neutralize NOX2-derived reactive oxygen species (ROS) in order to inhibit TNF-alpha-mediated host cell apoptosis (PubMed:20421951).  Also mediates inhibition of neutrophil apoptosis, leading to delayed activation of naive CD4 T cells (PubMed:22264515).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit G, NADH dehydrogenase I subunit G, NDH-1 subunit G.
What is the protein family that this protein belongs to?
Belongs to the complex I 75 kDa subunit family.
Protein: EIPR1_XENTR
Sequence: MEDDAPVIYGLEFQARALAAQTAETDAIRFLVGTQSLRYDNQIHVIDFDDENNIINKNILLHHAGEIWQISASPADRNVLATCYNKISDSKVLTCAAVWRIPKELQGGNHESPDDTSSNAQALELLCHLDNTAHGNMACVTWEPLGDGKKLLSLADNYLMIWDLQESSTKSVLSSSVTLEGKGQLRFTSGKWSPHHNCTQVATANDTAIRGWDIRSMRQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNIHEPVKTLEEHSHWVWSVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDEDLSDQEDNLQEEKTKEPLQDSVIATYEEHEDSVYAVEWSSADPWLFASLSYDGRLVINRVPRALKYNILL
What is the function of this protein?
May act as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network.
What are the official names of this protein?
EARP-interacting protein homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EIPR1 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network.
Protein: RECF_CLOBB
Sequence: MYIKAIMLANYRNYNNLELNLSEGVNVFIGDNAQGKTNVLESIYYCAFAKSHRTSRDKDLINWKENEAYISLLVGKKRLDKRIDIKILRDGKKAIKVNSIKINKIGELFGTFNVVMFSPEDLKIIKESPGIRRKFLDMELCQISKKYYFNLVQYNKILNERNVILRSRDFNKDILEVYDLQLVECADYIVKERLEYIDKINYYGKFIHNEITSGKEDIVFKYDSGIKFKDDFKYAFLEKLKNNLLRDREQGITSIGPHRDDFNVLINNIDVKKFGSQGQQRTAVLTMKFSSLKIIKEITKEYPILLLDDVLSELDINRKRYVLSTLNDIQTIITCTGINDLEDYLDDKSKVFKVCNGEIVN
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NR2E3_HUMAN
Sequence: METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
What is the function of this protein?
Orphan nuclear receptor of retinal photoreceptor cells.  Transcriptional factor that is an activator of rod development and repressor of cone development.  Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit.  Enhances rhodopsin expression.  Represses M- and S-cone opsin expression.
What are the official names of this protein?
Photoreceptor-specific nuclear receptor, Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS13_BURMA
Sequence: MARIAGVNIPNHQHTEIGLTAIFGIGRTRARSICVASGVAFSKKVKDLTDADLEKLREEVGKFVVEGDLRREVTMNIKRLMDLGCYRGVRHRKGLPLRGQRTRTNARTRKGPRRAAQALKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: UPPP_STRA1
Sequence: MLIIELLKALFLGVVEGVTEWLPVSSTGHLILVQEFMKLNQSKSFVEMFNIVIQLGAIMAVIVIYFKRLNPFQPGKSAREIRLTWQLWLKVVIACIPSILIALPFDNWFEAHFNFMIPIAIALIFYGFVFIWVEKRNAHLKPQVTELASMSYKTAFLIGCFQVLSIVPGTSRSGATILGAIIIGTSRSVAADFTFFLAIPTMFGYSGLKAVKYFLDGNVLSLDQSLILLVASLIAFVVSLYVIRFLTDYVKRHDFTIFGKYRIVLGSLLILYWLVVHLF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: H6ST1_CRIGR
Sequence: MVERASKFVLVVAGSACFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTPDPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDPAGLRSPRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCPYNLANNRQVRMLADLSLVGCYNLSFIPESKRAQLLLESAKKNLRGMAFFGLTEFQRKTQYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRHIEELNDLDMQLYDYAKDLFQQRYQYKRQLERREQRLRNREERLLHRSKEALPREDTEEPGRVPTEDYMSHIIEKW
What is the function of this protein?
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.  Also transfers sulfate to CDSNS-heparin and performs the crucial step modification in the biosynthesis of anticoagulant heparan sulfate (HSact).  Critical for normal neuronal development where it may play a role in neuron branching.  May also play a role in limb development.  May prefer iduronic acid.
What are the official names of this protein?
Heparan-sulfate 6-O-sulfotransferase 1, HS6ST-1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 6 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: MNMA_RICRO
Sequence: MINLGAKQSTIVVAMSGGVDSSAVAAMLNEQGHNVIGITLQLYDHGMAVGKKNACCAGQDIYDAKMVANKLGIPHYVLDYESKFKESVIDNFVDSYLQGETPLPCVQCNKSVKFRDLIKTARELGADKLATGHYVRKINGDNGAELHTGLDPAKDQSYFLFTTTKEQLEYLRFPLGGLTKGETRKLASKFGLEVADKPDSQDICFIPDGNYKSVINKIRPNSSESGKIIHVNGFELGEHSGIINYTIGQRRGLGIAYNEPLYVVKIDPKDNIVYVGPESALNVQEFIIRDVNWLADEIKDNEKLEVAVKIRSTRPPRLAEISKLGDDKMKVKFLCKEKAVAPGQACVIYAGARVLGGGWITREIR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGLR_ECOLI
Sequence: MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQGGKQ
What are the official names of this protein?
Beta-glucuronidase, GUS, Beta-D-glucuronoside glucuronosohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: GLMM_ACIBC
Sequence: MSYFGTDGIRGKFGQMPITPEFALKLGFAAGKVLKRTSPKNKPLVVLGKDTRLSGYILESALQAGLNAAGVYVHLLGPLPTPAIAHLTRALHAHAGIVISASHNPYFDNGIKFFSSEGKKLPDSLQEEINKELEKDLFIEDTANLGKSVRVTDANGRYIEFCKSTFPYHFDLNNLKIVVDCAHGAAYSVGPSVFRELGAKVVALYNEPDGLNINENCGSTHPESLQKAVVEHGADLGIAFDGDADRVVMVDKFGSLIDGDHILYILATQAKNKPAGVVGTVMSNMALEVALEKANVGFVRAKVGDRYVLQALEENGWVTGGEPSGHILTLDKSTTGDAIIAALQVLTVMVEQNKALHELVHDFKLYPQVLVNVRLEQMLDPYSIPALVAEFNKAEEQLKGRGRILIRKSGTEPVIRVMVEGDNEQEVKTLAEHLANAVRSQAQVA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RPOZ_BRUME
Sequence: MARVTVEDCVDKVENRFELVLLAGHRARQISQGAPITVDRDNDKNPVVALREIADETLSPDDLKEDLIHSLQKHVEVDEPEAAPAQIANAAEEIAEGIAEAGEEDVVTFDRMSEEELLAGIEGLVAPEKNDGF
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: SPIKE_BPPM2
Sequence: MIVKKKLAAGEFAETFKNGNNITIIKAVGELVLRAYGADGGEGLRTIVRQGVSIKGMNYTSVMLHTEYAQEIEYWVGDLDYSFQEQTTKSRDVNSFQIPLRDGVRELLPEDASRNRASIKSPVDIWIGGENMTALNGIVDGGRKFEAGQEFQINTFGSVNYWVSDEEIRVFKEYSARAKYAQNEGRTALEANNVPFFDIDVPPELDGVPFSLKARVRHKSKGVDGLGDYTSISVKPAFYITEGDETTDTLIKYTSYGSTGSHSGYDFDDNTLDVMVTLSAGVHRVFPVETELDYDAVQEVQHDWYDESFTTFIEVYSDDPLLTVKGYAQILMERT
What is the function of this protein?
Receptor binding protein located at the fivefold vertices.
What are the official names of this protein?
Spike protein P1, Protein I.
What are the subcellular locations of this protein?
Virion.
Protein: ZN618_HUMAN
Sequence: MNQPGGAAAPQADGASAAGRKSTASRERLKRSQKSTKVEGPEPVPAEASLSAEQGTMTEVKVKTELPDDYIQEVIWQGEAKEEKKAVSKDGTSDVPAEICVVIGGVRNQQTLDGKAPEGSPHGGSVRSRYSGTWIFDQALRYASGSYECGICGKKYKYYNCFQTHVRAHRDTEATSGEGASQSNNFRYTCDICGKKYKYYSCFQEHRDLHAVDVFSVEGAPENRADPFDQGVVATDEVKEEPPEPFQKIGPKTGNYTCEFCGKQYKYYTPYQEHVALHAPISTAPGWEPPDDPDTGSECSHPEVSPSPRFVAAKTQTNQSGKKAPASVVRCATLLHRTPPATQTQTFRTPNSGSPASKATAAESAFSRRVEGKAQNHFEETNSSSQNSSEPYTCGACGIQFQFYNNLLEHMQSHAADNENNIASNQSRSPPAVVEEKWKPQAQRNSANNTTTSGLTPNSMIPEKERQNIAERLLRVMCADLGALSVVSGKEFLKLAQTLVDSGARYGAFSVTEILGNFNTLALKHLPRMYNQVKVKVTCALGSNACLGIGVTCHSQSVGPDSCYILTAYQAEGNHIKSYVLGVKGADIRDSGDLVHHWVQNVLSEFVMSEIRTVYVTDCRVSTSAFSKAGMCLRCSACALNSVVQSVLSKRTLQARSMHEVIELLNVCEDLAGSTGLAKETFGSLEETSPPPCWNSVTDSLLLVHERYEQICEFYSRAKKMNLIQSLNKHLLSNLAAILTPVKQAVIELSNESQPTLQLVLPTYVRLEKLFTAKANDAGTVSKLCHLFLEALKENFKVHPAHKVAMILDPQQKLRPVPPYQHEEIIGKVCELINEVKESWAEEADFEPAAKKPRSAAVENPAAQEDDRLGKNEVYDYLQEPLFQATPDLFQYWSCVTQKHTKLAKLAFWLLAVPAVGARSGCVNMCEQALLIKRRRLLSPEDMNKLMFLKSNML
What is the function of this protein?
Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization.
What are the official names of this protein?
Zinc finger protein 618.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes at genomic loci that are enriched for 5-hydroxymethylcytosine (5hmC).
Protein: MSCL_ECO24
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLTEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIMO_VIBVY
Sequence: MTVQTFTPNQTTTLDTAKKTIEQQSQELTPSGGNKIGFVSLGCPKNLVDSERILTQLRTEGYEIVNSYHDSDVVIVNTCGFIDSAVQESLDTIGEALKENGKVIVTGCLGAREDEIREVHPGVLGITGPHAYENVLEHVHQFAPKPEHNPFTSLVPDHGVKLTPKHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPVGEILSEAERLKNAGVKELLVISQDTSAYGVDSKHSLGFANGSPVRQNIKALSEELGKMGIWVRLHYVYPYPHVDDLIPLMAEGKILPYLDIPFQHASPNVLKAMKRPGRAERTLDQIKKWREICPELVIRSTFIVGFPGETDEDFEMLLEWLKEAQLDRVGCFKYSPVEGAAANDIDDQISEEVKQERFERFMLVQQEISAAKLQKRIGSTMKVIIDEVDEEGAIGRTYADAPEIDGLVYLNGETSLKAGELVDVLIEHADEYDLWGSLVRA
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JTX2B_CHIFL
Sequence: MDPRISSRLRALALLVFVISITDGIPNRAKRSSSEINAEIDGLIQQLTTVDADTKGIQETLTELKTTVSANPSRISQVSAVVKSVGSSLAKFKTGDPYNIVSGCLDILSSIATTYNGPYGVGLGAVASLLSSVIGLFAQDGFKNSLKSIVDEAFKRYRDEELQGQLKGASRTFNDVIGTLKNLTDKDTAVTDLEFSLATSSVSVSQFSNMLGIIESRINTGSTTTDLAEAKRTVDFIFLYLELAVMRETLLTQLILFTKKLGKFENYANGISASIDANKQAVHDTILFLHQMEPKNAVCGAYYYPVHHSDVSEGIFTFTRYFGLPDPPRNTFQGVYRVENRYWPAWHICKESYMGNHMFRGCSYIKSAGVHISALDNGYLKLNLKGKNMYITKHAQGWAWGTADNDPGEQGYFIFVPLKSGYYMISTKKWPNYFVYMESSASGYIRSWHNNPGLQGHWKLT
What is the function of this protein?
The fraction containing this toxin and CfTX-B shows potent hemolytic activity (PubMed:24403082).  This fraction causes minor effects on the cardiovascular system of anesthetized rats (at 25 ug/kg), since it has no significant effects on heart rate but produces relatively small increases in mean arterial pressure (PubMed:24403082).
What are the official names of this protein?
Toxin CfTX-B, Toxin B, TX-B.
What is the protein family that this protein belongs to?
Belongs to the jellyfish toxin family. Type II subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Target cell membrane. Note=Forms a membrane channel in the prey.
Protein: CCNB2_RANJA
Sequence: MATRRAAIAREVDNAVGAMRSKAQLNGRRAALGEIGNKVTVRAVKQPAKNSNTTSKTTRPVAKVSNVSVKPKAVTVTEAPSQVKEASPVPMDVSMKEEEELCQAFSEVLNHVVDIDAEDGGNPQLCSEYVVDIYNYLREREVQQSIKQRYLDGMEINERMRAILVDWLIQVNSRFQFLQETLYMGIAIMDRFLQVQPISRGKLQLVGVTSLLLASKYEEMYSPEVADFAYITDNAYTTSQIREMEMIILRELKFDLGRPLPLHFLRRASKACSADAEQHTLAKYLMELTLVDYEMVHFHPSEIAAAALCLAQKVLGVGSWGSTQHHYTGYTEEDLTPIIKHIAKNVTKVNQNRTKHVAVRNKYASSKLMKISTHPQLMSLVITELAASLTSQ
What is the function of this protein?
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
What are the official names of this protein?
G2/mitotic-specific cyclin-B2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: Y5759_CUPNH
Sequence: MQDSALERTRIAAVNAARAARASYRAGTVQPTAGIAPGMTQANMIALPRDWAWDFLLYAQRNPKACPVLDVIEAGAQQTVLAQGADIRTDIPLYRVWRDGKLAEEVADATPLWTEHPDLVTFLIGCSFTFETPLQEAGIEVRHIADGSNVPMYRTNRQCRPAGRLHGEMVVSMRPIPAHRVADAVSISGRFPSVHGSPVHVGDPAALGIADLARPDFGDAVRIEPGEIPVFWACGVTPQAAVMASGVPFAVTHAPGHMFITDVPDSTYHV
What are the official names of this protein?
Putative hydro-lyase H16_B1759.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: TYW2_MACFA
Sequence: MGENVVVSNMERETGKPVAVVAVVTEPRFTQRYREYLERQKLFDTQHRVEKMPDGWVALPVLGETLPEQHLQELRNRVAPGSACMLTRLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGVKWSAELEADLPRSWQRHGNLLLLSEDCFQANQWKNLGPELWETVASALGVQRLAKRGRVSPDGTRTPAVTLLLGDHGWVEHVDNGILYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKLKLSNIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQPLEVSKTEKEHWLYPQQITTNQWKNGATRDTRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQILHIQPVKSYAPHVDHIVLDLECCPCPSVG
What is the function of this protein?
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.  Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity).
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 2 homolog, tRNA-yW-synthesizing protein 2, tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
Protein: ARPC1_DICDI
Sequence: MSAFEIEHLASCITAHAWNADRSRVALCPNNNEVHIYAKQGTSWVVEHVLAEHDQLVTSIDWAPKTNRILTSSQDRNAYVWTFKDGQWKPVLVLLRINRAATHVKWSPQENKFAVATGAKLVCICFFEEEHDWWASNHIKKHKSTVLKVDWHPNNLLLATSSSDYKVRVFDAYIKKADGRSVTRPYGEVAFGEPVFEFDQCASWVHALKWSPSGSTLAYSSHDGVFAVANFSTNPPTIEKLRVRNLPLRDLLYITENSIAGVGYDCAPLLITNQNGWKYSGEMDKASEGGAAAGSETSARKLFQNKVDLGESKSADKKLTTVHQNCITSIVPFKSVGGVVSDFSTSGLDGNIVVWHVKALEAKNKFKVI
What is the function of this protein?
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the pointed end of the daughter actin filament.  The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis.  In concert with a group of other proteins, the Arp2/3 complex plays a general role in the rapid activation and adaptation of the actin system to its multiple functions.
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 1, Arp2/3 complex 41 kDa subunit, p41-Arc.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ARPC1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Cytoplasm, cytosol. Cytoplasm, cell cortex. Cell projection, pseudopodium.