PharMolix/UniProtQA huggingface dataset:
Protein: Y8322_DICDI
Sequence: MGDDESDNNNNNNNNNNNNNNNNIGCKILKTVISGRRSILLESYNNNNKNKNNNNIIIKSYEDEFNLFKLNNKKELSIEKLQTIAKDNGLPFDENENDLYNRIEIYYNIKIKLEKEVKQQHDNNPFNKGHPILLINNDNKNEILFWKVFRNKLIFKNIFSNFKYSNLFNYSRLFSVYNIYNDFNNCIEIIRDKVKSNSYLAFGHCLDNFSGLSTILKNIKKDTQENQLFHNRLLNNYCNKLIHAGNFFKIIIESFNLLALKSFFNNKTLKIKKVKINFEINKISELKFLEYLFNNHKEYIEIQKIIITILKPNIFEKFKLGELIKLVMILYDDEIYTKIEKLDNLKNKLIYNKIKEFQFSDKELNENLLTLLKPVTKSDRFYIKLNDNYNNKLNIIFKYINIFYKLVGGSTIKPFEYYFTHMGEKELIENKPNEINQRQTKMVINSNIKRILLKNNNDTHETINSIKSIDMLDSLFNNYQDQFFKDRNENWKYVNSITILKHYEKLMLSLGRKFSFNNSNVIEIGSKGIQSKLYLIAINNPSLYQVIGEKKKKKDYVLNLNFIAFPGKLTFISLIESNYFKNIKISESLEFTKYITISRWISDNCISIFSDNNKPEIYIQLPNLKKINIVSGISSGSGISSGSGGNDGKIKIILDQLQLVQILYNSNRIDDIFKIKNLDSNIITSFIKNISPHISLDFVNRLIIRGYFNNYQKKNNFLNQIVLNNNLPIIKFLYLNHSSCFFYYNLKDLLLLAISNDNYQIAELFFVFCNFTRKELKSVIKTKFSLIELIHGNKLKLGIEIIKK
What are the official names of this protein?
Putative uncharacterized protein DDB_G0281631.
Protein: LEU1_COREF
Sequence: MPVKRYLPFEVEVEDITLPDRTWPDKKITQAPQWCAVDLRDGNQALIDPMSPERKRRMFELLVKMGFKEIEVGFPSASQTDFDFVREIIEKNMIPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRDVVFRMNKDQVKTLATDAAELIKTIAQDYPDTNWRWEYSPESYTGTEVEYAKEVVDAVVEVMDPTPENPIIINLPATVEMITPNVYADSIEWMHRNLNRRDSIILSLHPHNDRGTGVAAAELGYMAGADRIEGCLFGNGERTGNVCLVTLALNMLTQGVDPQLDFSDIKHIRRTVEYCNQLRVPERHPYGGDLVFTAFSGSHQDAINKGLDALAAKVKPGASSTEVAWEELRSTEWEVPYLPIDPKDVGRDYEAVIRVNSQSGKGGVAYIMKTDHGLKMPRSMQVEFSAVVQNVTDAEGGEVNSKEMWDIFATEYLDRSAPVEQIALRVENAQTENDDATITAELVVDGENQTVSGRGNGPLAAYANALESLNIDVEIQEYSQHARTSGDDAEAAAYVLAEVNGRMVWGVGIAGSITYASLKAVTSAVNRALDFKHQQLQNGGV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: XYN_PENCH
Sequence: MIPNITQLKTAALVMLFAGQALSGPVESRQASESIDAKFKAHGKKYLGNIADQGTLNGNPKTPAIIKANFGQLSPENSMKWDATEPSQGQFSFAGSDYFVEFAETNGKLIRGHTLVWHSQLPSWVSSITDKTTLTDVMKNHITTVMKQYKGKVYAWDVVNEIFEEDGTLRDSVFSRVLGEDFVRIAFETAREADPEAKLYINDYNLDSATSAKLQGMVSHVKKWIAAGVPIDGIGSQTHLGAGAGAAASGALNALASAGTEEVAVTELDIAGASSTDYVDVVNACLDQPKCVGITVWGVADPDSWRADESPLLFDASYNPKEAYNVSQLLSRQHAFDLYLKLGNLLLSRLHSD
What is the function of this protein?
Cold active endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
What are the official names of this protein?
Endo-1,4-beta-xylanase, Xylanase, 1,4-beta-D-xylan xylanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
What are the subcellular locations of this protein?
Secreted.
Protein: AFTS1_ALTAL
Sequence: MNYEKWRHPPVSLVESVKASRAVYKRLGNSGLVVSNPILGGMHIGNPKWNDWVLDEKESIALLKAAYERGVNTWDTANMYSNGESEKIMGKALRVHNIPRSKVVIMTKCCRAVTDPNIEPDIGISTAFYPELSGQSKDYVNHFGLSRASIFQQVEASLQRLNTDYIDVLQIHRFDPEVPPEETMKALHDLVQMNKVRYLGASSMWAHEFAILQHAAEKNNWTKFVSMQNHYSLLYREEEREMIKYCNLTGVGVISWGSLASGRLARPPDQRTVSPRGVNGTIYKDYNPTQSEEIIRRVHQTAVSRGIPMSQVALAWLNKRIVAPVIGLSSVERIDEALDAKAVELSHEEERYLESAYRAQSIQGHA
What is the function of this protein?
Aldo-keto reductase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) AF-toxins responsible for Alternaria black spot of strawberry disease by the strawberry pathotype (PubMed:12019223).  AF-toxin I and III are valine derivatives of 2,3-dyhydroxy-isovaleric acid and 2-hydroxy-isovaleric acid respectively, while AF II is an isoleucine derivative of 2-hydroxy-valeric acid (PubMed:15066029, Ref. 3, PubMed:22846083).  These derivatives are bound to a 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) moiety (PubMed:15066029, Ref. 3, PubMed:22846083).  On cellular level, AF-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The aldo-keto reductase AFTS1 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV) by reduction of its ketone to an alcohol (PubMed:15066029).  The acyl-CoA ligase AFT1, the hydrolase AFT2 and the enoyl-CoA hydratases AFT3 and AFT6, but also the polyketide synthase AFT9, the acyl-CoA dehydrogenase AFT10, the cytochrome P450 monooxygenase AFT11 and the oxidoreductase AFT12 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common EDA structural moiety (PubMed:12019223, Ref. 3, PubMed:18986255).  The exact function of each enzyme, and of additional enzymes identified within the AF-toxin clusters have still to be determined (PubMed:12019223, Ref. 3, PubMed:18986255).
What are the official names of this protein?
Aldo-keto reductase AFTS1, AF-toxin biosynthesis protein S1.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: MVHA_METTH
Sequence: MVKLTMEPVTRIEGHAKITVHLDDAGNVEDTRLHVMEFRGFEKFLQGRPIEEAPRIVPRICGICDVQHHLAAAKAVDACFGFEPEDVLPAAYKMREIMNWGSYMHSHGLHFYFLAAPDFIAGKDRKTRNVFQIIKDAPDIALQAIELRKNALELVRATGGRPIHPTSSTPGGISTELDDETQKDLLKKAQRNVELAEATLELAVPIFEENIDLVNSLGNIETYHTGLVKDGVWDVYDGIVRIKDKEGNMFREFKPADYADTIAEHVKPYSWLKFPYIKDLGYPDGVYRVSPLSRLNVADKMPDAAPKAQEHFKEFRENFGYAQQTLLYHWARLIELLACAECAADALEGDLSGEKFPDSLERQAGDGVGIVEAPRGTLTHHYTCDENGLITKANIVVATIQNNPAMEMGIQKVAQDYIKPGVEVDDKIFNLMEMVIRAYDPCLSCATHTIDSQMRLATLEVYDSEGDLVKRI
What is the function of this protein?
Part of a complex that provides reducing equivalents for heterodisulfide reductase.
What are the official names of this protein?
F420-non-reducing hydrogenase subunit A, Methyl viologen-reducing hydrogenase subunit alpha, MVH subunit A.
What is the protein family that this protein belongs to?
Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
Protein: P2RY6_HUMAN
Sequence: MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR
What is the function of this protein?
Receptor for extracellular UDP > UTP > ATP.  The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
P2Y purinoceptor 6, P2Y6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAD26_MOUSE
Sequence: MDTRGCAWLLLLLSLPQGQSHQPLHRSKRRWVLTTLELQEEDPGPFPKLVGELFNNMSNNVSLIYLIRGPGVDEFPEIGLFSIEDHQSGKIYVHRPVDREVTPSFMVHFDAVDRSTGKVVDESLIFNIRIRDVNDHAPQFPEKEFNISVKESQAAGQPIFQLLTVDLDQENTPNSQVLYFLVSQTPLLRESGFRIDLISGEVRLSGCLHYETAPLFTLIVRASDCGEPSLTSTATIHVSVEDSNNHMPTFMEDRYEIRISEGQVEQGVLYLPVQDGDSPFTPAWRTQFNIWDGNEEGHFDIVTDPETNQGLLSIIKPLDYESQVAHSLVVVVENQEQLFVCTEGQLQPLRKAMASTMVSVQVLDTNDPPAFHPQSFIVSEEDGAWPAIQLGYFNATDPDRADSQIRYKLVHDPENWVTVDEKSGVVTTKKQIDRESPHVNDSFYTIIVHAVDNGLPPLTGTGTLMLFLSDVNDNAPTLRPHSRHLEVCESAGSQPLLIEAEDADLDPYADPFTFDLDNAQGDVEETWMLRTKQGEGHSAELTMLRSVPPGDYLVPLFIADRQGLAQKQTVHVRICSCRSGSECEEPSDTWLLWWALSPVGAALMVLSAALLCLLRCSCTFGPKRLRGFIPSDSGHQTLIVYNEESKVPSAQGCDTFFEPRGVKTLLSSTPVYLDRMVPRQQPLQLLEGRVVEAWSQKLQSIDVLEGDTGYLPHVYREEGECEGAETLSSLTFLEQDLSPKLLGCSGSKSTPSEAMCFTSRVPS
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.  Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation.
What are the official names of this protein?
Cadherin-like protein 26.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: DRC5_CHLRE
Sequence: MAAPNLITPLRDICVKVVAANFEGCPTFGPLPDKYVKRIIDILPLDLPLELVGSLIADEDYWRRRSQARWKNCEVAAHGYSWKQLFFERNLMEFLEQYDPAVTDLSSLKRLLTYSRRFVQTVHIRQLPSHLDLQILFECMVNTPSSLALSYNLKEVGMDYDRSLFGMKLSDCRALAKALEHTETLTHLDLSNNSLDDDKVRMLASGLVENLSITHLNLSHNKIADRGVRALAKLLDGHSVISLLELHDNQIHTEGAESLARAFKSNQCLLSVNLRLNRMGDEGCKAVVESVRGSPTLQRLNISANAAGPGTAAAVVALLRLNNTLTELDVSCNQFGEDACGNVRRALEQNGSVRLMDVRMTGINPDDEMAIAENLRARQERVDKARVLGK
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (PubMed:23427265, PubMed:25411337).  May play a role in the assembly of N-DRC (PubMed:23427265).
What are the official names of this protein?
Dynein regulatory complex subunit 5, Flagellar-associated protein 155.
What is the protein family that this protein belongs to?
Belongs to the DRC5 family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Detected along the length of the sperm flagellum.
Protein: HRTB_STAS1
Sequence: MKLAWQEIKYYKFRYILIMLIILLLGIMVLFISGLAQGLARENISMLDNMKSEKYVLQDNKQPQIEKSIIKPEQQNKIEDITGQEPLKMAPQTLKIDKNEEDVLMINTVKNEKPELKAGHYPTKDNEVAINNKLTADGINVGDKIKLKDGKALKVSGVLNDTMYSHSSVVMMSDNGFNTLNKQASTIYPVKDLSKSEQEKVNDISGVKVFTENDITSEIPSYQAEQAPLNMMIVSLFVISAIVLSAFFYVMTIQKIPEIGILKAIGMKTKHLLSALIIQILITTMIGVIISVAIITGLSFLMPVSMPFHVTTSNLLLVVGVFIIVAIIGAILSFIKLFKVDPIEAIGGGE
What is the function of this protein?
Part of the ABC transporter complex hrt involved in hemin import.  Responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Putative hemin transport system permease protein HrtB.
What is the protein family that this protein belongs to?
Belongs to the ABC-4 integral membrane protein family. HrtB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RR18_AMBTC
Sequence: MDKSKQPFRKSKRSFRRRLPPIGSGDRIDYRNMSLIGRFISEQGKILSRRVNRLTLKQQRLITIAIKQARILSPLPFLNNEKQFERTESLPRITGTRTIKK
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PGK_CROS8
Sequence: MSVIKMTDLDLAGKRVLIRADLNVPVKEGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTEGEYNEEFSLLPVVNYLKDKLNSPVRLAKDYLDGVEVAEGELVVLENVRFNKGEKKDDETLAKKYASLCDVFVMDAFGTAHRAQASTHGVAKFADVACAGPLLAEELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYEADLVDEAKRLLGTCDIPVPTDVRVATEFSETAPATLKSVTEIKDEEQILDMGDVSAEKLAEILKNAKTILWNGPVGVFEFPNFRKGTEIVARAIAESDAFSIAGGGDTLAAIDMFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEERAKK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_RHOP5
Sequence: MSKANTTNARRKNRVRMALRRTASGRPRLSVFRSSKHIYAQVIDDLKGVTLASASSLEKTMREAGNTGADIDAAKAVGKLLAERAVKNGVKEVVFDRGGYLYHGRIKALADAARESGLSF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CYSD_BRUO2
Sequence: MKNLTHLQRLEAEAIHVFREVAATFSNPVMLYSVGKDSSVMLHLAMKAFYPAPPPFPFLHVDTTWKFREMIEFRDAQAREKGFELLVHVNEQGVRDGIGPFTHGSNVHTHIMKTVGLRQALDKYRFDAAFGGARRDEEKSRAKERIFSFRNAQHGWDPKNQRPEMWKIYNTRVSKGESIRVFPLSNWTELDIWQYILQENIPIVPLYFAARRPVVERDGMLIMVDDDRMKLRPGEQVENRLVRFRTLGCYPLTGAIPSSAANLSDIVEEMLIARTSERQGRAIDRDEAGSMEKKKREGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: Y105_ARCFU
Sequence: MKENVAGALSYLLGPITGILFLLMEKESQFVKFHAMQSTITFAGFWVLDIALSFIPYIGVLLIPIVGLVAFITWLVCIYKAYSNEWFKLPVVGDIAEQQIGGV
What are the official names of this protein?
UPF0132 membrane protein AF_0105.
What is the protein family that this protein belongs to?
Belongs to the UPF0132 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: H2B11_ORYSI
Sequence: MAPKAEKKPAEKKPVEEKAEKKPKAEKRVPGAKEGGGEKKGKKKAKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAQEAARLARYNKKPTITSREIQTSVRLVLPGELAKHAVSEGTKAVTKFTSS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.11.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MSRA_YERP3
Sequence: MQNVDNTAVIDAANALPGRLTSIPVSPLHAVHGHSMTYIPEGMDLAFFAMGCFWGAERLFWQQPGVYSTAAGYSGGHTPNPTYHEVCSGRTGHAEVVRVVFDPAVISYQQLLQIFWENHDPAQGMRQGGDVGTQYRSAIYVLTPEQEEQAHKSRERFQQAMEKAGDQRVITSEITVALPFYYAEDDHQQYLHKNPHGYCGLGGIGVCLPPNV
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: JIP1_MOUSE
Sequence: MAERESGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGSSGSAGSRLQAEMLQMDLIDAAGDTPGAEDDEEEEDDELAAQRPGVGPPKAESNQDPAPRSQGQGPGTGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGSPVPTQDRGTSTDSPCRRSAATQMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDPAEPTSTFMPPTESRMSVSSDPDPAAYSVTAGRPHPSISEEDEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCVINGEEHEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWIDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDALEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
What is the function of this protein?
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.  Required for JNK activation in response to excitotoxic stress.  Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun.  May also participate in ApoER2-specific reelin signaling.  Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function.  Appears to have a role in cell signaling in mature and developing nerve terminals.  May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins.  Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity).  Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway.  Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells (PubMed:23963642).
What are the official names of this protein?
C-Jun-amino-terminal kinase-interacting protein 1, JIP-1, JNK-interacting protein 1, Islet-brain-1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the JIP scaffold family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity).
Protein: PLSB_SHEFN
Sequence: MSKPDSIFLRALRWIQKWMVQTIVVPHDPFDDLNIDPTKPLVYLMKTESISDIAALSEITEGFGLPSPYEPLQLDGLTVPRVVCLEGRKPLFGKRESGDKFLNYFTSLLSLHSESPELDIQLVPVCLYWGRTPGKEEDSMKAAVFERENPTWLRKWLMILFLGRHNFVQFSNALSLRHMADEHGTDKRIAHKLTRVARVHFRRQRKVMTGPQLPNRQALFASLLKSESIKKAIEEESANKKVTVEKARETAIEYLDEIAADYSDSLVRIAERFLTWLWNKLYSGINIKGAEQVRQLHHDGHEIVYVPCHRSHMDYLLLSYILYYQGMVPPHIAAGINLNFWPAGPMFRRGGAFFIRRSFNGNKLYTAVFREYLDQLFAKGYAVEYFTEGGRSRTGRLLAPKTGMLAMTINSVLRGIERPVTLVPVYLGYDHVMEVATYHKELSGKKKKKESVWQVFGAIRKLGNFGQGYVNFGEPINLQQFLNQQAPEWRDELAKDPDQKPSWFTPSVNLLANRVMTNINGAAAASSVTLTSLVLLASEQNALERSQLERQLDLYLALLKTVPYTEYASVAEGNGKSIVDHCLSLNKFVSTKDLIGEIISVDEKIAITMSYYRNNIIHLMALPSLIASCLVHYDVCDRQRIHAIVMDFYPLLKAELFMSIDDVPKHVDCILDFMVEQGLLTGSDQFEITPRHITQVLLLAETISETLQRYAIIFNLLAIKPDLERSELERDSHLLAQRLGALHGITAPEFYDKKLYNTLSVKLKELGYLCSDEHRAEVIRIRDNANKLLSSLVRQTIVDSVEAEHGQ
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SLYX_ECOHS
Sequence: MQDLSLEARLAELESRLAFQEITIEELNVTVTAHEMEMAKLRDHLRLLTEKLKASQPSNIASQAEETPPPHY
What are the official names of this protein?
Protein SlyX.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: RL21_BURCJ
Sequence: MYAVIKTGGKQYKVAVGEKLKVEQIPADIDAEITLDQVLAVGEGESIKFGTPLVSGASVKATVVSHGRHAKVTIFKMRRRKHYQKHGGHRQNYTELRIDAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: SYI_RICAE
Sequence: MTNTKYYPEVNSNADFAGLEREILKFWQDNNIFQKSIDDRNGELEFIFYDGPPFANGLPHYGHLLTGFIKDVYARYQTIKGKKVERRFGWDCHGLPAEMQSEKELGISGRLAIANFGIEKFNAHCRASVMKYANDWEEYVTRQARWVNFKNSYKTMDKNFMESVLWAFKELYNKGLLYESMRVMPYSWACETPLSNFETRLDNSYRERADKAVTVSFVLSHPVATTTGSFKEYRILAWTTTPWTLPSNLALAVGSDIDYALVPKNDVCYIIAAYSVSKYAKELGLSGEENFEIIKGSALQGLNYKSLFDYFENHPNSFKIFAGDFVVEGDGTGVVHMAPGFGEDDQILCESKGIELVCPVDNSGKFTKEIPDLEGLQVFDANDKIIIKLKEQGNWLKTEQYIHNYPHCWRTDTPLIYKAVPSWYVKVTQFKDRMVELNQQINWIPFHVKDNLFGKWLENARDWSISRNRFWGTPLPVWKSDDPKYPRIDVYGSIEELEKDFGVKVTDLHRPFIDELTRPNPDDPTGKSTMRRIEDVFDCWFESGSMPYGQAHYPFENKEWFEDHFPADFIVEYSAQTRGWFYTLMVLSTALFDRPPFLNCICHGIILDSTGQKLSKRLNNYADPLELFDKYGSDALRVTMLSSNVVKGQELLIDKDGKMVFDTLRLFIKPIWNAYHFFTMYANTDSLKGKLNFSSKNVLDVYILSKLKIAVQKIEESLDNFDTQTAYHAVSEFFEVLNNWYIRRSRARFWKSEKDTDKQNAYNTLYSCLDTMAIAMSALVPMISEAIYKGLHHCEERNDTALSGKSNVIVRKDTSLDKAISGVSHKIATALSVPCNDAISVHLCNYPTLSDFEINHELVATMDNVLDICSNSLFIRSTENIRVRQPLASIAIISKHNNNLKDFEDLIKDEINVKAVIYRDDLENYASKKLSINFPMLGKRLPHKMKEIIAASKKGEWEAIAGGLAICGETLNSDEYKLVLEPYSHIKGAASFENNSSLLILDLELTPELIEEGYARDIVRFIQQARKDADFSITDRILIEIISEFNLSKIIDNYGDFIKEQTLGEFAKNFTPDYVSKVELENHQIQLKVKKS
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_CLOB1
Sequence: MSFDFIKDKNKHIHFIGIGGISMSGLAEILLYNNFSISGSDMNSSPITEKLKDKGAKIYIGHKKENVKDADLIVYTAAIASDNPEITKAKEKNIKLMDRADFLGNLMKGYKYNIAISGTHGKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGESDFFITEACEYKSSFLKFFPYIGVILNIDADHLDYYKDLDDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEASCNVITYGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNMKDKDIIEGIESFFGTHRRFELKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVFQPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGIISSDMLGDKLRDRGLKCTNFHKFDDIKNYLIENTKDGDLILTVGAGDIYKVGEMYINL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NNTM_HUMAN
Sequence: MANLLKTVVTGCSCPLLSNLGSCKGLRVKKDFLRTFYTHQELWCKAPVKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQNLVKQGFNVVVESGAGEASKFSDDHYRVAGAQIQGAKEVLASDLVVKVRAPMVNPTLGVHEADLLKTSGTLISFIYPAQNPELLNKLSQRKTTVLAMDQVPRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFDVKDDFDFGTMGHVIRGTVVMKDGKVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMSTASAYTAGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHLYPSTTSQGLAALAAFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPAGTFVGGYLAALYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLAATLGVLKPGPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIAEYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLIAYGKLQGLLKSAPLLLPGRHLLNAGLLAASVGGIIPFMVDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK
What is the function of this protein?
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity).  May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (PubMed:22634753).
What are the official names of this protein?
NAD(P) transhydrogenase, mitochondrial, Nicotinamide nucleotide transhydrogenase, Pyridine nucleotide transhydrogenase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PNT beta subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.