PharMolix/UniProtQA huggingface dataset:
Protein: ARC1_DROME
Sequence: MAQLTQMTNEQLRELIEAVRAAAVGAAGSAAAAGGADASRGKGNFSACTHSFGGTRDHDVVEEFIGNIETYKDVEGISDENALKGISLLFYGMASTWWQGVRKEATTWKEAIALIREHFSPTKPAYQIYMEFFQNKQDDHDPIDTFVIQKRALLAQLPSGRHDEETELDLLFGLLNIKYRKHISRHSVHTFKDLLEQGRIIEHNNQEDEEQLATAKNTRGSKRTTRCTYCSFRGHTFDNCRKRQKDRQEEQHEE
What is the function of this protein?
Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915).  Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915).  Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915).  May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).
What are the official names of this protein?
Activity-regulated cytoskeleton associated protein 1, dArc1.
What is the protein family that this protein belongs to?
Belongs to the ARC/ARG3.1 family.
What are the subcellular locations of this protein?
Extracellular vesicle membrane. Synapse. Note=Forms virion-like extracellular vesicles that are released from neurons (PubMed:29328915). Present at pre- and postsynaptic sites of the neuromuscular junction (PubMed:29328915).
Protein: Y4764_MYCA1
Sequence: MAATAEVGVTATLGAAARAVATRQGLLNDPYAEPLLGAVGIDYLTRAIADHTFAADESPVGDDPAVTSLLDALAAHTRFVDEFLAEAGRAGIRQVVILASGLDTRPYRLWWPRGTTVYEIDRPRVLDFKAGVLRGLDARLATNRCAVGIDLRDDWPAALRRVGFDAAQPTAWVAEQLLVGYLKPAEQNRLLRRLTAASAAGSRLAADHLPTWDPLQLEAERAFVEGWRRRGLDIDLASLTHPGEYHYVPEYLATHGWEPAARSIADLLGALGLGPRRRAGSGGAQFIPEYVTATRV
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MAV_4764.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: FTHS_RHIME
Sequence: MGEVKSDIEIARAARKQPIMEVGAKLGIPPEHLLPYGHDKAKVSAEFIAAQNEKRNGRLILVTAINPTPAGEGKTTTTVGLGDGLNRIGKKAIVCIREASLGPCFGIKGGAAGGGYAQVVPMEDINLHFTGDFHAITSAHNLLSALIDNHIYWGNEQAIDIRRIAWRRVMDMNDRALRQIVGSLGGVANGYPRETGFDITVASEVMAILCLAMDIKDLEKRLGNIIIGYRRDKSPVFARDIKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVTEAGFGADLGAEKFFDIKCRKAGLTPDAAVIVATVRAIKMNGGVKREDLGRESVEAVRKGCANLGRHIQNVKKFGVPVLVAINHFTSDTEAEVRAIKDYVRTLGSEAVLCKHWAEGSAGIEELAYKVVDLANAGHSQFSPLYPDEMPLFQKIETIAKDIYHASEVIADKLVREQLRTWEDQGYGDLPICMAKTQYSFSTDPNLRGAPTGHAVPIREVRLAAGAGFIVVITGEIMTMPGLPKVPSSERIRLNEQGYIEGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: CXL17_HUMAN
Sequence: MKVLISSLLLLLPLMLMSMVSSSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL
What is the function of this protein?
Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
What are the official names of this protein?
C-X-C motif chemokine 17, 6-Cys CXCL17, Dendritic cell and monocyte chemokine-like protein, DMC, VEGF coregulated chemokine 1.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLME_SINMW
Sequence: MTKPPVGSNRSGRKLGQKVKKGKLKASSRRWIERHINDPYVQRAQLEGYRARAAFKLLEIDEKHKILAGARRIIDLGAAPGSWSQIAAKVTNSTDTDPRVAAIDFLEMDAIPGVSFLQMDFLDPQAPEKLKEAIGGAPDIVLSDMAAPTTGHRQTDHIRTMHLCEVAAHFAVEVLAEGGHFLAKTFQGGTERDLLNMLKQNFRQVVHVKPASSRAESVEMFLLAKGFKGRHASRSDEPAEGAAEK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSK_DAUCA
Sequence: YIYTQ
What is the function of this protein?
In presence of 2,4-D, stimulates proliferation of the cells, but does not stimulate differentiation into the somatic embryos.
What are the official names of this protein?
Phytosulfokine-alpha, PSK-alpha.
What is the protein family that this protein belongs to?
Belongs to the phytosulfokine family.
What are the subcellular locations of this protein?
Secreted.
Protein: CMOA_SALPA
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPNTQVYDLGCSLGAATLSVRRNIRHEHCRIIAVDNSPAMIERCRRHIDAYKAPTPVEVVEGDIRDITIENASMVVLNFTLQFLEPAERQALLDKIYLGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLRQAGFEHSELWFQCFNFGSLVALKAGVAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: RS15_MESAU
Sequence: MAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
40S ribosomal protein S15, RIG protein.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: ERT1_YEAST
Sequence: MCTPDENDYKTSTDPDTSANTNHTLEKKKRKKRKNTNVACVNCSRLHVSCEAKRPCLRCISKGLTATCVDAPRKKSKYLAGIPNRELPMNIQPDLPPRKIMIPIYNNSSNSSLNVNNMGEQQKFTSPQHIVHKAKFLSNAADSEYSILSNIIYQDTLSNKIPIDILYSNTNSTSNSTIGNSSNNSPTGTNTSPEETEMEKIRQLYSEQRANIPPHPYPSSNQNVYSILLGPNSAKIVASQVNLFANHFPLVPVDSADNSLNFKRLLPRDPSEKSSQINWDSSINQYYLNSETVTFPELAIPLKRRKNHLVSVSLESCSPDAANIKSNVEWEHSLRYSTPMEIYTSINAPFSHTPGFHHLLVYLKHRFNQQDLVKMCRSIAEFRPIFIACSVTLTEEDMIFMEQCYQRTLLEYVKFIAQIGTPTCIWRRNGQISYVNEEFEILCGWTREELLNKMTFIVEIMDDESVRDYFKTLSKVAYRDFRGSEKMKVCRLLSPIKGKIIHCCCMWTLKRDVSGLPLMILGNFMPILN
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes like PCK1.  Involved in restriction of Ty1 transposition.
What are the official names of this protein?
Transcription activator of gluconeogenesis ERT1, Ethanol regulator of translation 1.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FA311_LITFA
Sequence: LDLAKHVIGIASKL
What is the function of this protein?
Lacks antibacterial activity against Gram-positive or Gram-negative bacteria.
What are the official names of this protein?
Fallaxidin-3.1.1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MSBA_IDILO
Sequence: MDSQLKKKTTFKRLLGYIKPYKAAFIAAILCMIGYSAIDTLFLSQIETLIDDGLTEQDSNILLYGALFVPFIFILRGSLNVASSYFLHWVGFKVVTKMRQQLFDHMMKLPVGFHDQHSTGDLISKITYDTQQVAEASSRAVLVLVKEGAFVAGLLGLMFYQSWQLSLVFLVIGPLVAKVVGVVSRRFRKVSSRIQTAMGNVTTTAEQMINGHKVVIMHQGQKGESTRFSEINNITRNQNMKLVNTRAISTSVIQFIASLSLSMVLVIASFPEMLGELSAGAFTTLLTAMIMLLRPLKQLTNVNSDFQRGIAAATSVFAILDEPIEVDKGSRVVDRAAGDIVFDDVTFSYQKDDEPALEHINFKVDQGKTVALVGRSGSGKSTISNLLTRFYDVEQGSILLDGHNINDYKLKCLRRQFALVSQHVTLFNDTIANNIAYGASKDVSRENIIKAAEQAYVTEFTDSMPKGLDTMVGENGVMLSGGQRQRIAIARALLQDAPILILDEATSALDTESERHIQDALGTLRKNRTAIVIAHRLSTIENADEILVMDNGEIIERGTHQQLLDQEGAYFQLHNLQFSGSA
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPA_DRANE
Sequence: MVTIRADEISNIIRERIEQYNREVTIVNTGTVLQVGDGIARIYGLDEVMAGELVEFEEGTIGIALNLESNNVGVVLMGDGLMIQEGSSVKATGKIAQIPVSEAYLGRVINALANPIDGRGKISASESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAIGQKASSVAQVVTSLQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYREQHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSQLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFSQFSSDLDKATQNQLARGQRLRELLKQSQSAPLTVEEQIMTIYTGTNGYLDGLEIGQVRKFLVQLRTYLKTNKPQFQEIISSTKTLTAEAESFLKEGIQEQLERFLLLEKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: TRBG_RHIRD
Sequence: MNIRHRRQRATLAIGLLVFAIVPLTVLDPRTALAADGVTANEAKGMGLSTQWRGSKGLVTKGADGKVIFLYGEVQPSVVCSPLQVCDIELQGGEVVRDVLVGDTVRWKVEPRHRALAGGQAIHLIVKPSEPGLVTSMVVTTSRRTYHIQLKSHPTQYMARVGFEYPEDVSTKLADVNARLEASTIPGTGVPAEQLSFSYSISGSAGWRPTRVYSDGLKTYIQFPRSISGQDAPVLFVVSGGQNRIVNYRMKSNMMVVDYNIDRAVLVSGVGWKQQKVTISRGGR
What are the official names of this protein?
Conjugal transfer protein TrbG.
What is the protein family that this protein belongs to?
Belongs to the TrbG/VirB9 family.
Protein: IF3_BRUA4
Sequence: MRRPFRATPVQKDGPRSNRDIRVPRVQLIDAEGQNHGDVSIQEAIAMAEEAGLDLVEIVPNAEPPVCKIVDLGKLKYQNQKKAAEARKKQKTVEIKEIKMRPNIDTHDYEVKMKAALRFFEEGDKVKVTLRFRGREMAHQELGMKLLQRVKEDTVEIAKVESEPKLEGRQMMMVLAPR
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_BLOFL
Sequence: MSDLSNFDVIIVGGGHAGTESALASSRMKCKTLLITHNVDTIGQMSCNPSIGGIGKGHLVKEVDAMGGIMAKAIDQSGIQFRILNTRKGAAVKSTRAQADKILYRQAIRHALEIQDSLFILQASVEDLIIKQNKVIGVVIPKIAIEIYAKSVVLTTGTFLNGKIHIGMNNFKGGRSGDLESSSSLSQKLRDLSFRINRLKTGTSPRIHAKGVNFDCMSVQNSDSPLPVFSFTGSFEQHPKQIPCYSTYTNKKTHDIIRLNLNQSPVYSGLINGISPRYCPSIEDKVVRFSDRDAHQVFLEPEGLTTSEIYVNGVSTSLPFNIQTEIIHSIFGLENAHIIRPGYAIEYDFFDPRDLKLTLESKFISGLFLSGQINGTTGYEEAAAQGILAGINAARYVQNKPGWYPRRDQAYLGVLVDDLCTYGTKEPYRMFTSRSEYRLSLREDNADLRLTTVAREFGLIDDNRWRIFCLKQENIEKERQRLRNTYIFPYSEDIVQLNRFLNSPIKNKVSGEDLLKRPEMNYVKLMQLNTFQSVKLDYQVFEQVEIQIKYSGYLLRQQEEIKKYLYYENTLLPIDINYHDIAGLSKEVIDKFNDCRPYSIGQASRIPGVTPAAISNVLIWLKKQGLLKKNVKCT
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXK_HUMAN
Sequence: MEEECRVLSIQSHVIRGYVGNRAATFPLQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSDELQELYEGLRLNNMNKYDYVLTGYTRDKSFLAMVVDIVQELKQQNPRLVYVCDPVLGDKWDGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGPDTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAMLLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGEGVRPSPMQLELRMVQSKRDIEDPEIVVQATVL
What is the function of this protein?
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:9099727, PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503) (Probable).  PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.
What are the official names of this protein?
Pyridoxal kinase, Pyridoxine kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: THI4_SOLM1
Sequence: MSLDERIITQAILETYFEKFKSSLDLDVAIVGGGPSGMTAARLLAADGFNVALFERKLSLGGGMWGGGMTFNMIVVQEESVHLLTDVGVPVKRYKDNYFTADAVAATTTLASAACLAGAKIFNCMSVEDVMLREENGVKRVTGIVINSSPVEIAGLHVDPVVLGSKYLVEATGHAVEVLQTLVRKNDVRLNTPSGGIEGEQSMWADTAEINTVKNTREIFPGLYVAGMAANASYGSYRMGPIFGGMLLSGEKVAADIAAKLKG
What is the function of this protein?
Involved in the biosynthesis of the thiazole moiety of thiamine.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
What are the official names of this protein?
Thiamine thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
Protein: EF1B_ARCFU
Sequence: MGSVMMKIRVMPSDVDVDLNEVLEKIKNIQMEGVEIRDSAIQPIAFGLKAIVLMAVMPDMEGIGDRYIEEIGKIEGVESVEIEDMELL
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: MEND_BACCN
Sequence: MNNHIEALSYYLGAFVDELARLNVCDVVISPGSRSTPLALLMEQHEQIKTYLHVDERSAAFFALGMAKAKKQPVAILCTSGTAAANYYPAVCEAYHARVPLLVLTADRPHELRDVGAPQAMNQFNLYGSFVKQFMEMALPEAREPMYQYVRMAAGRAVASASFAPMGPVHMNFPLREPLIPDFSLDGLWEQGCGEYTNRVQQGSMTLTSEYIRSLIKRLSRLEKGLIVCGDDSHLELVEVIAEFAEKTGYPVLADPLSNLRTGSHNQTMIIDCYDTFLRNELLKDTWKPDIIIRFGGMPVSKALTQYIKKQESAVHIIVDESGKWRDPALMTTEVVSASDVAFCKAMTEHMQKREQNDWFKKWKHINDKTKETLREVEAYDTAFEGKVITDIVRILPEGATLFVSNSMPIRDADTFLFTNEKKIHVMANRGVNGIDGIISTALGASTVCEPLVLVIGDLSFYHDLNGLLAAKLHDLNITIVVVNNDGGGIFSFLPQYESKEHFESLFGTPLGLDYEHVVKMYGGSFVRVSGWEAFREEVQKGIIERGLHVVEICTNREENVQLHRKLWAKSVIEIKDMLQGDTE
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: RN216_HUMAN
Sequence: MEEGNNNEEVIHLNNFHCHRGQEWINLRDGPITISDSSDEERIPMLVTPAPQQHEEEDLDDDVILTEDDSEDDYGEFLDLGPPGISEFTKPSGQTEREPKPGPSHNQAANDIVNPRSEQKVIILEEGSLLYTESDPLETQNQSSEDSETELLSNLGESAALADDQAIEEDCWLDHPYFQSLNQQPREITNQVVPQERQPEAELGRLLFQHEFPGPAFPRPEPQQGGISGPSSPQPAHPLGEFEDQQLASDDEEPGPAFPMQESQEPNLENIWGQEAAEVDQELVELLVKETEARFPDVANGFIEEIIHFKNYYDLNVLCNFLLENPDYPKREDRIIINPSSSLLASQDETKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKVLSSQDIKWALHELKGHYAITRKALSDAIKKWQELSPETSGKRKKRKQMNQYSYIDFKFEQGDIKIEKRMFFLENKRRHCRSYDRRALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQPQMPPYAFAHPPFPLPPVRPVFNNFPLNMGPIPAPYVPPLPNVRVNYDFGPIHMPLEHNLPMHFGPQPRHRF
What is the function of this protein?
Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome.  Promotes degradation of TRAF3, TLR4 and TLR9.  Contributes to the regulation of antiviral responses.  Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production.  Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B.  Promotes TNF and RIP mediated apoptosis.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF216, RING finger protein 216, RING-type E3 ubiquitin transferase RNF216, Triad domain-containing protein 3, Ubiquitin-conjugating enzyme 7-interacting protein 1, Zinc finger protein inhibiting NF-kappa-B.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAP22_CHAGB
Sequence: MAAQAPPTDELSKLSVEDADNKPQPDASNGNLNHDEDDSEDDAEDASAPAAGGAKKKKKRKPRKKKKNPTQQSDPPRVLISQLFPDKQYPKGEEVEYLNENSYRTTNEEKRHLDNLKSEFLNDYRHAAEAHRQVRQWAAKNIKPGQSLTDIANGIEDSVRALVGHQGLEEGDALIAGMGFPTGLSINHCAAHYTPNAGNKMILQQDDVMKIDFGVQVNGNIVDSAFTMAFNPRYDPLLEAVKAATNAGIKEAGIDVRLGEIGGVIQEVMESYEVEIDGTTYPVKPIRNLNGHTILPYNIHGGKSVPIVKSNDTTKMEEGDVFAIETFGSTGGGHVIEDGEVSHYAKRTDAPKVDLRLSSAKSLLSVINKNFGTLPWCRRYLDRLGQEKYLLGLNNLVSNGIVEAYPPLVDKKGSYTAQFEHTILIRPTVKEVISRGDDF
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-2, MAP 2-2, MetAP 2-2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPRA_ECOLX
Sequence: MIQTRNQYLQFMLVMLAAWGISWGARFVMEQAVLLYGSGKNYLFFSHGTVLMYLLCVFLVYRRWIAPLPVVGQLRNVGVPWLVGAMAVVYVGVFLLGKALALPAEPFMTKLFADKSIPDVILTLLTIFILAPLNEETLFRGIMLNVFRSRYCWTMWLGALITSLLFVAAHSQYQNLLTLAELFLVGLITSVARIRSGGLLLPVLLHMEATTLGLLFG
What are the official names of this protein?
Uncharacterized 24.3 kDa protein, URF 1.
Protein: SYT_MYCPN
Sequence: MLAGVLLLQSWLKANYPQVQFGSYGVQEGEFYLDFKVEKSFSIKEFEQLEQDLNAYFNQLNNVVQTKIDKTKSLKFFQADPFTTTLIESIESNSLVVTTVNEQTFWVHDLVLPLPKQGFVKLLNVSANYFLGDPTKPQLQRLVGIFAASKEQLKSLIAANEQKYQNDHRAIGKRLEIFTFDPLVGAGFPIWLEKGAVLKKIIGDFVHYQQLMFGFKTVSSPVLANLELYKISGHYVHYSEDMFPSVKLENQMMMLRPMTCPHHCLIFKHKRRSYKELPQRFCEDSILHRFEASGGLTGLERVRCMTLLDNHIFCRTDQIKAEIKNAFKLIQTVNNKFGFSFDRIDLALHDPNNKAKFIDNDQLWANSESQIESVFKELNVPYKIDVGAAAFYGPKIDFQFKTALNKMITIATIQLDFLLPERFELRYFDEQSNAQTPVIIHVGIVGTYERFIAALLEKTHGNLPLWMAPVQVVVIPVNIDKHEKAAKKLYQKLLKENIRVSLDESEDRLGKKVRTAIVNKIPLQIIVGDKEMQDLTRITCRGFKGEKVQKLYWANFVKKVRKDG
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA_ACIAD
Sequence: MRIDLNSDLGESYGSWIMGNDEQILPMVSSANIACGFHAGDPLGIFKTLKQAAKLGVTVGAHVSYPDLAGFGRRNMQLSYDELLTDVMYQISALQGLAKAAGTTVKYVKPHGALYNTIATDLQQAQAVLDAIKCLDSDLILVGLAGSPLITFAQQNGLNVVAEAFADRAYNADGSLVSRRLAGAVLHDPDFVAKRVVKMIQEGGVISIDGHFTPISAQSICLHGDTDGALSMAAAIRNALLTEGIEIRSFCEVN
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: CXXC1_HUMAN
Sequence: MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEPRDEGGGRKRPVPDPDLQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATPEPLSDEDLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADEVCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSSADR
What is the function of this protein?
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
What are the official names of this protein?
CXXC-type zinc finger protein 1, CpG-binding protein, PHD finger and CXXC domain-containing protein 1.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes.
Protein: O263_CONTS
Sequence: MEKLTILLLVAAVLMSTQALIQRGGAKRRKVNFFSIREPGAEDWREGNCTPWLGGCTSPEECCPGNCETYCRAWR
What are the official names of this protein?
Conotoxin TsMEKL-011.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP8_CEREH
Sequence: MPQLDTSTWLMMIMSMFLALFIIFQLKISKHNFHFNPELTLTKTQKQKTPWETKWTKIYLPLLLPQ
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: RLMI_SHIF8
Sequence: MSVRLVLAKGREKSLLRRHPWVFSGAVARMEGKASLGETIDIVDHQGKWLARGAYSPASQIRARVWTFDPSESIDIAFFSRRLQQAQKWRDWLAQKDGLDSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALISALQTLYPECAIYDRSDVAVRKKEGMELTQGLVTGELPPALLPIEEHGMKLLVDIHHGHKTAYYLDQRDSRLATRRYVENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQLLNEGGILLTFSCSGLMTSDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVM
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.