PharMolix/UniProtQA huggingface dataset:
Protein: UVRB_CHLTR
Sequence: MGGGVLKQQFVLHAPFLPCGDQPEAIRRLSQGITDGVPAQVLLGTTGSGKTFTMANVIANVNVPTLVLAHNKTLAAQLYQEFKAFFPENAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKLRLSATRSILERRDTLIVSSISCIYGIGSPDNYSSMALTLEVGKEYPRSQLSSQLVRMHYQASSTPQRSAFRERGSVIDIFLAYESDLAVRLEFMNDTLISIEYVDPLTMIPSHTTSSITLYPGSHYVTPEAVREQAIRTIREELEQRMLFFEGRPVEQERLFQRTTHDIEMIKEIGFCKGIENYSRHFTGAAPGEPPTCLLDYFPDDFLLIIDESHQTLPQLRAMYRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEARRYFHRVIYVSATPGDLEIQESRGHIIEQIIRPTGIPDPLPEIRPAKGQIDDLLEEIRQRLRKDQEKILVISVTKKLAEDIAAFLAELGIAATYLHSGIETAERTQILTDLRLGNIDVLIGVNLLREGIDLPEVSLVAILDADKEGFLRSSASLIQFCGRAARNIHGKVICYADRITPSMDHMLKETERRRKIQLDYNQQHKITPQPIIKPILANPITKEAGQEETRLKMQSSKELEASIKTYEEAMYQAAQEFQFDEAAKYRDLMNAAKKQLLFQKGEEENGD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OMP2A_BRUCA
Sequence: MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKGARFALMFNTNSETELGTLGTYTQLRFNYTSNNSRHDGQYGDFSDDRDVADGGVSTGTDLQFAYITLGGFKVGIDESEFHTFTGYLGDVINDDVVAAGSYRTGKIAYTFTGGNGFSAVIALEQGGEDVDNDYTIDGYMPHVVGGLKYAGGWGSIAGAVAYDPVIEEWATKVRGDVNITDRFSVWLQGAYSSAATPNQNYGQWGGDWAVWGGAKFIATEKATFNLQAAHDDWGKTAVTANVAYQLVPGFTITPEVSYTKFGGEWKDTVAEDNAWGGIVRFQRSF
What is the function of this protein?
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
What are the official names of this protein?
Porin Omp2a.
What is the protein family that this protein belongs to?
Belongs to the alphaproteobacteria porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: RPOA_ACOCL
Sequence: MVREEVVGSTRALQWKCVESRADSKRLYYGRFILSPLLKGQADTIGIAMRRALLGEIEGTCITRAKSEKVPHEYSTIAGIEESVHEILMNLKEIVLRSNLYGTRDASICVRGPRCVTAQDIISPPSVEVVDTTQHIASLTEPIDLCIGLQIQRDRGYRMKTTKNSQDGSYPIDAVSMPVRNANHSIHSYGNGNQKQEILFLEIWTNGSLTPKEALHEASRNLIDLFIPFLHAEEEDINFEENQNRFTVPPFTFPDRLANLKKNKKEIALKCIFIDQSELPPRTYNCLKRSNIHTLLDLLSNSQEDLMKIEYFRIEDVKQILDTLQKHFAIDLPKNKF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PA2B1_AGKPI
Sequence: NLFQFEKLIKKMTGKSGMLWYSAYGCYCGWGGQGRPKDATDRCCFVHDCCYGKVTGCNPKMDIYTYSVDNGNIVCGGTNPCKKQICECDRAAAICFRDNLKTYDSKTYWKYPKKNCKEESEPC
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 APP-D49, svPLA2, App-dimer, AppP3, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPD_ALIFM
Sequence: MSEMATIARPYAKAAFDFAVEKGELSQWAQMLTFCSEVAKNKDVAQLLDGAVASEQLAEIFISICGEQLNEFGQNLIHVMAENGRLKVLPGVLEQFILLQHEFEKVIDADVTSAIELTEQQKADIGAKLEARLERKVKLNCSVDETLLAGVIIRAGDLVIDNSARGRLGRLSETLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CDK14_CALJA
Sequence: MSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPTNQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
What is the function of this protein?
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin.  Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway.  Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3.  Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo.  May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 14, Cell division protein kinase 14.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.
Protein: MAIA_ASPFU
Sequence: MEDSTSPKVTLYTYFRSSCSARLRIALNLKSIPYTPIAVNLLKGEQSSPENIALNPSGTVPTLIVEHDSKEPVTITQSLAALEYLEEITPASSHALLPPASNPEARAVVRTLVDIMSCDVQPVTNLRILKRVAPFGVDRAAWSKDLIEDGFRAYEAIAAKSAGLFSVGDSITMADVCLLPAVWGAERAGVKVEKFPTIYRVAQRLEEEDAVKRAHWRTQPDTPEEFRVSSS
What is the function of this protein?
Maleylacetoacetate isomerase; part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin (PubMed:19028908, PubMed:22046314).  The 4-hydroxyphenylpyruvate dioxygenase hppD catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisic acid (HGA) (PubMed:19028908, PubMed:22046314).  The protein hmgX is crucial for this conversion and thus, probably functions as an accessory factor to mediate specific activity of hppD (PubMed:22046314).  The homogentisate 1,2-dioxygenase hmgA is then involved in the cleavage of the aromatic ring of HGA and its conversion to 4-maleylacetoacetate (PubMed:19028908, PubMed:19715768).  When hmgA activity is lowered by the cell wall integrity (CWI) signaling pathway, HGA accumulates and leads to the production of pyomelanin through benzoquinone acetic acid after oxidation and polymerization (PubMed:19715768).  On the opposite, in non-stress conditions, both hppD and hmgA activities are balanced and HGA is degraded into 4-maleylacetoacetate (PubMed:19715768).  4-maleylacetoacetate is further converted to 4-fumarylacetoacetate by the maleylacetoacetate isomerase maiA, which is degraded into fumarate and acetoacetate by the fumarylacetoacetase fahA (Probable).
What are the official names of this protein?
Maleylacetoacetate isomerase maiA.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Zeta family.
Protein: MUTS_CHLAA
Sequence: MATIELHAWYRQYRKLKEEAADAILLFRFGDFYETFDDDAKLIAELLDITLTRKEYAVDKRLPKDQQKLYAPMAGMPYHAVDRYVSELIARGYRVAIAEQLSETEAMRNDTRPRSVYAAGLTPVESSGKMVQRAIVRVITPGTVIDPAMLPDRTNNYLAAVIVEQGKVGLAYADLSTGEFAAAEFTDARALMQLQAELARLSPAEVLVPDDEALRLPNLEPVQARLSQDLAPLTKEEREALLPHERVARRLEGASAASWTQGYVTEWPLWRWELATTTEVLCEHLALPSLAVCGLDGRPLATRAAGALLQYAQVTQRQRVSQLRALRVYHTGAYMLLDPQTRRNLELLESGGRQGAKASLIAVLDRTCTAMGARLLRRWITQPLIVIEPLQVRQHAVARLVAETMARLEVRSALADLPDMERALNRIAQGITVATPRDMTQLRAALRKLPAVAQAVQALLPDLLAAEMPGEPPLVFDVCADVLDLLERALDDDPPALLGSSNYLRAAEEGGERPRRVIRPGFDQRLDALIRASRHAQEFIDRLESKERERTGIRSLKVGYNQVFGYYIEISRAVDAKLIPAHYERKQTLVNAERYVTEELKYYEGLLSDARLKLVDLERDIFQRLCDELQPHLDRLRATIAAVARIDALAALAEVAVRGRYVQPRLRTDRVLRIKQGRHPVVERTLSEPFIGNDIDLDGEQAQILIITGPNMAGKSTFLRQVALITLMAQIGSFVPADEAEIGLVDRIFTRIGAQDDIATGQSTFMVEMTETAALLMQSTPRSLIILDEVGRGTSTYDGMAIARAVVEYIHDHPRLGCRTLFATHYHELIALERELPRVRNYHMAAVERDGRVVFLHELRPGGADRSYGIHVAELAGIPPEVIRRASALLADLEGQRPPSSPAQPPAPPAPVVVPAQETGQGMQLSFFDLAPHPVVEYLRRLRIEELTPLEALNRLAELQRLAGQG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: PERM1_HUMAN
Sequence: MENFQYSVQLSDQDWAEFSATADECGLLQAGLASGDELLSSDIDQGDSSGSSPPRAPPLPTGQLAAGGRSRRGCEEEDVATQQPVSRSQGEPVLALGTGQQTPSTSARAEAPPSLGPGASPPSQFSSCPGPASSGDQMQRLLQGPAPRPPGEPPGSPKSPGHSTGSQRPPDSPGAPPRSPSRKKRRAVGAKGGGHTGASASAQTGSPLLPAASPETAKLMAKAGQEELGPGPAGAPEPGPRSPVQEDRPGPGLGLSTPVPVTEQGTDQIRTPRRAKLHTVSTTVWEALPDVSRAKSDMAVSTPASEPQPDRDMAVSTPASEPQSDRDMAVSTPASEPQPDTDMAVSTPASEPQPDRDMAVSIPASKPQSDTAVSTPASEPQSSVALSTPISKPQLDTDVAVSTPASKHGLDVALPTAGPVAKLEVASSPPVSEAVPRMTESSGLVSTPVPRADAAGLAWPPTRRAGPDVVEMEAVVSEPSAGAPGCCSGAPALGLTQVPRKKKVRFSVAGPSPNKPGSGQASARPSAPQTATGAHGGPGAWEAVAVGPRPHQPRILKHLPRPPPSAVTRVGPGSSFAVTLPEAYEFFFCDTIEENEEAEAAAAGQDPAGVQWPDMCEFFFPDVGAQRSRRRGSPEPLPRADPVPAPIPGDPVPISIPEVYEHFFFGEDRLEGVLGPAVPLPLQALEPPRSASEGAGPGTPLKPAVVERLHLALRRAGELRGPVPSFAFSQNDMCLVFVAFATWAVRTSDPHTPDAWKTALLANVGTISAIRYFRRQVGQGRRSHSPSPSS
What is the function of this protein?
Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity.  Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A.  Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.
What are the official names of this protein?
PGC-1 and ERR-induced regulator in muscle protein 1, PPARGC1 and ESRR-induced regulator in muscle 1, Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shows a nuclear localization in the presence of PPARGC1A.
Protein: S5A2_PIG
Sequence: MPVRCQQSPVLAGSATLAALGALALYFAEPSGYGKYTESLTPAAIRLPARAAWFLQELPSFVVPAGILAGQPRSLFGPPATVLLGLFCAHYFHRTFVYSLLTRGRPFPVVFLFRGFVFCMGNGLLQGYYLVYCAEYPAEWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEVIYKIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYVKMFEDYPKSRKALIPFIF
What is the function of this protein?
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids.  It plays a central role in sexual differentiation and androgen physiology (By similarity).
What are the official names of this protein?
3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, SR type 2, Steroid 5-alpha-reductase 2, S5AR 2.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family.
What are the subcellular locations of this protein?
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ZN609_MOUSE
Sequence: MSLSSGACGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEKDQQKLEMSGSKEVGIPAPNAVATLPDNIKFVTPVPGPQGKEGKSKSKRSKSGKDASKPTPGTSLFSPSEGAASKKEVQGRAGDGASAGGLVAAVAPKGSEKAAKASRSVAGSKKEKENSSSKGKKERSEGVGTCSEKDPGVLQPVPLGGRGSQYDGSAGMDTGTVEPLGSIAIEPGAALNPLGTKPEPEEGENECRPLKKVKSEKMESPVSTPAVLPLHLLVPVVNNDISSPCEQIMVRTRSVGVNTCDVALATEPECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWRNKTYVGTLLDCTRHDWAPPRFCDSPTSDLEMRNGRGRGKRMRPSSNTPVSEAAAASDSKGTSSSSKTRAGANSKGRRGSQNSSEHRPPASSTSEDVKASPSSANKRKSKPLSDMELNSSSEDSKGSKRVRTNSMGSATGPLPGTKVEPTLVDRNCPSPVLIDCPHPNCNKKYKHINGLKYHQAHAHTDDDSKPEADGDSEYGEEPALHADLSCNGAPVPQKGSLSPARSATPKVRLVEPHSPSPSSKFSTKGLCKKKLSGEGDTDPGALSNDGSDDGPSVMDETSNDAFDSLERKCMEKEKCKKPSSLKSEKIPSKSLKSARPIAPAIPPQQIYTFQTATFTAASPGSSSGLTTTVVQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKKKDSSKELESPLTPGKVCRAEEGKSPFRDAAGDGIKVESLLNGSSESHQSRLASIKAEADKIYSFTDNAPSPSIGGSSRLDSTTPTQPLTPLHVVTQNGAEASSVKTNSPAYSDISDAGEDGEGKVDSAKSKDPEQLVKEGAKKTLFPPQPQSKDSPYYQGFESYYSPGYAQSSPGTLTSSSQAGMEGQPLKTKKDEEPESVEGKVKNDVCEEKKPELSNSSQQPSVIQQRPNMYMQSLYYNQYAYVPPYGYSDQSYHSHLLSTNTAYRQQYEEQQKRQSLEQQQQQQRGLDKKTEMGLKEREASLKEEWKQKPSIPPTLTKAPSLTDLVKSGPGKAKEPGTDPAKSVIIPKLDDSSKLPSQPPEGLKGKLGEASHLGKEASEAKTGTECGRQAEVDPILWYRQETESRMWTYVYPAKYSDIKSEDDRWKEERDRKLKEDRSRSKDSVPKEDGKESTSSDCKLPPSEESRLGSKEPRPSVHVPVSSPLTQHQSYIPYMHGYSYSQSYDPNHPSYRGMPAVMMQNYPGSYLPSSYSFSPYGSKVSGGEDADKARASPSVSCKASSESKALDILQQHASHYKSKSPTISDKNSQERDRGGCGVVGGGGSCGSVAGAGGTDRSADRPRTSPSQRLMSTHHHHHHLGYSLLPAQYNLPYAAGLSSTAIVASQQGSTPSLYPPPRR
What is the function of this protein?
Involved in regulation of myoblast proliferation during myogenesis.
What are the official names of this protein?
Zinc finger protein 609.
What are the subcellular locations of this protein?
Nucleus.
Protein: NADE_PSEAB
Sequence: MQQIQRDIAQALQVQPPFQSEADVQAQIARRIAFIQQCLKDAGLKTLVLGISGGVDSLTAGLLAQRAVEQLREQTGDQAYRFIAVRLPYQVQQDEADAQASLATIRADEEQTVNIGPSVKALAEQLEALEGLEPAKSDFVIGNIKARIRMVAQYAIAGARGGLVIGTDHAAEAVMGFFTKFGDGACDLAPLSGLAKHQVRALARALGAPENLVEKIPTADLEDLRPGHPDEASHGVTYAEIDAFLHGQPLREEAARVIVDTYHKTQHKRELPKAP
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: LPTD_BORPA
Sequence: MRMLRWLILSAFSVAGAVQAQGNQDSAAASASSASIGAPVLRTSPGLRVHRLPDEKIPAFMEADQISGDPDSEVTLTGNAQVRRVDGIIKGDRINYRRDTGDVDVQGSARMLRDGTLITGPSARLNVDTYSGEIQEPNFWIGASGGTAQARHADIFSKSQMRLSQVTYSGCPCPKPSWYIKADTVDLDFDENEGVARNGVLYFKDVPILASPYLTFPVKKERKSGFLMPTYGTTSNSGFDISLPYYFNLAPNYDLTLVPRYLSKRGAQLGGEFRYLGSGYRGVAIGTYLPDDNETGRDRWMYRTYHRQLLGNGFYTDWDIAGASDDNYFRDISELGLNTASTTYLPRRGRVGWSSTYWQTYAQVYKYQTLQDPDAPLAPPYDKVPELWLKGARYDWGGFDAEWVSTAVRFQRPLLNGRRLGPDGDRLQTYPTVSYPIVRPGWFLVPKVGVHYTQYRTDWYNRDWNRIGLSNYKRTESRTVPIMSLDAGMIFERDASLFGKAATQTLEPRLYYLRVPYRDQSALPVYDTTLADFSFDQAFQENIYTGGWDRIANANQLTAALTTRWLDANTGFERLSLSAAQRIYFQDQEVTLPAEQPRKNVRSDFLVGATAALTDTLTTDVAAQYNPYDNKWSRGMVSARWSPQRLTTVAVAYRYQRDPLPGISYQPQGQNQVSLAVQWPIHRRWYGVGRVDYSLRSEPATAAAAEQSPRVTQAIAGLEYKGDCCWVGRVVYQRYAVSAADTNTALFFQLELTGLGALGTDPISLLNRSIPGYQSVVPPTPTGTTFERYE
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: TX72F_SCOMU
Sequence: MLVFYAILFVTVFSNTVMGATIDKPIPKPIFREAIEEMEVNKRAKNPYCKEEKCPVGKHCPKKPIVCRIGPCCV
What is the function of this protein?
Inhibits voltage-gated potassium channels.
What are the official names of this protein?
Kappa-scoloptoxin(07)-Ssm2f, Kappa-SLPTX(07)-Ssm2f, Kappa-scoloptoxin-Ssm2f, Kappa-SLPTX-Ssm2f.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-07 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GCH4_COPPD
Sequence: MRDVQSERDPRNVPLDYVGIENVRLPITVRTKEGGKQPTVGTFSIGVDFPHSFRGTHMSRFMEVLYQHLEEISQTRLRVTLEDIKERLKATKAMIEVAFPFAIKKSTPVTKLETVMYVDASFKAELNSTRGYVVTSTVTVPVHSLCPCSRDISEFGAHNQRVDVTVSWQGDLWIEDVIALVESSASQPLYPLLKRPDEKYVTEKAYLNPKFVEDIAKDLFLKLDPLSPCFRIKVVSYESIHPHNAVAIKEKRAEVSESSVRSNDQEHRDCT
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RS14_NEIMA
Sequence: MAKKALINRDLKRQALAKKYAAKRAAIKAVINDSNATEEERFEARLRFQSIPRNAAPVRQRRRCALTGRPRGTFRKFGLGRIKIREIAMRGEIPGVVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: AOFA_HUMAN
Sequence: MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
What is the function of this protein?
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519).  Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519).  Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
What are the official names of this protein?
Amine oxidase [flavin-containing] A, Monoamine oxidase type A, MAO-A.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Protein: TGT_SHEON
Sequence: MKFELDTTDGRARRGRLIFDRGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFLDPEKSMQIQHALGSDVVMIFDECTPYPATEDEARKSMQMSLRWAKRSRDEFDRLENPNSLFGIIQGSVYEDLRDESLKGLVEIGFDGYAVGGLAVGEPKEDMHRILEHVCPQILADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFTSEGVIKIRNARHRDDTSPLDPKCDCYTCKNYSRAYLYHLDRCNEILGARLNTIHNLRYYQMLMEGLRGAIETGTLDAFVKDFYTSQGREVPELVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: QUEC_METBF
Sequence: MKAITLLSSGLDSVAALAIAAEDFDIEMAITFDYGQRAREREIEYSRKVCEYFGIEHRVIKLDWLSEITSTSLVNRDVEVPSLSFEDIGEAAPAEITDASAKAVWVPNRNGVMLNIAGSFAESRECEYLVVGFNGEEAGTFPDNSLDYVKAMDRAFFYSTQNGVKILAPLIELGKTEIVRRALEAKAPLEYSWSCYRGEEIPCGECESCVRRARAFKNAGVKDPLLERLGI
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, Archaeosine biosynthesis protein QueC, PreQ(0) synthase.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: EZ1_MAIZE
Sequence: MEAEAAAAVVASSASASASAGRSRPSSSAAQVTSNSAVRAGEENAASLYVLSVIDSLKKRITADRLTYIKNRIGENKTNISSYTQRTYNLSKNRQISTSKGTDSASNLLTKRQDDALCTLHSLDIIPVDKDGGTFQDESPFSSSNVMFGGNLGPKNAIIRPIKLPEVPKLPPYTTWIFLDRNQRMTEDQSVLGRRRIYYDTSCGEALICSDSEDEAIEDEEEKKEFKHSEDHIIRMTVQECGMSDAVLQTLARHMERAADDIKARYEILHGEKTKDSCKKGTEHNVKVEDLYCDKDLDAALDSFDNLFCRRCLVFDCKLHGCSQDLVFPTEKQPAWSGVDDSVPCGIHCHKLASEPDAAAGADHMLFDVEEPTHSSDNVMNQPGSNRKKNGSSGRKTKSQQSESSSTARVISESSDSEVHPISNKSPQHSPSPSKVKIGPKGGIRKITNRRIAERILMSVKKGQREMASSDSNFVSGYLLARDMKLRSDTRNGNKELIVSSQQSSPSTRSSKKKSTPQIGNSSAFAEAHNDSTEEANNRHSATDGYDSSRKEEFVNENLCKQEVYLRSWKAIEQGLLVKGLEIFGRNSCLIARNLLGGMKTCKDVFQYMNYIENNSASGALSGVDSLVKGYIKGTELRTRSRYFRRRGKVRRLKYTWKSAGYNFKRITERKDQPCRQYNPCGCQSTCGKQCPCLSNGTCCEKYCGCPKICKNRFRGCHCAKSQCRSRQCPCFAADRECDPDVCRNCWVGCGDGTLGVPNQRGDNYECRNMKLLLKQQQRVLLGRSDVSGWGAFLKNSVSKHEYLGEYTGELISHKEADKRGKIYDRENSSFLFNLNNEYVLDAYRMGDKLKFANHAPDPNCYAKVIMVTGDHRVGIFAKERILAGEELFYDYRYEPDRAPAWARKPEASGAKDDGQPFNGRAKKLAQNNRG
What is the function of this protein?
Polycomb group (PcG) protein.  Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes.  PcG proteins are not required to initiate repression, but to maintain it during later stages of development (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase EZ1, Enhancer of zeste protein 1.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: IAAB_HORVU
Sequence: MASKSSCDLLLAAVLVSIFAAVAAVGSEDCTPWTATPITPLPSCRDYVEQQACRIETPGPPYLAKQQCCGELANIPQQCRCQALRFFMGRKSRPDQSGLMELPGCPREVQMDFVRILVTPGFCNLTTVHNTPYCLAMDEWQWNRQFCSS
What is the function of this protein?
Part of a complex with inhibitory activity, but CMb is inactive as a separate subunit.
What are the official names of this protein?
Alpha-amylase/trypsin inhibitor CMb, Chloroform/methanol-soluble protein CMb.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I6 (cereal trypsin/alpha-amylase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: METAA_STRGC
Sequence: MPIKIDKKLPAVEILSSENIFVMDDDRADHQDIRPLNILVLNLMPQKMVTETQILRHLANTPLQLTIDFLYMSSHQSKTTRAEHMETFYKTFDEVKNRYFDGLIITGAPVEHLPFEAVDYWEEFQQVIEWSKTHVFSTLHICWGAQAGLYARYGVDKHQMTRKLSGVYSQSADSNNLLFRGFDDEFYAPHSRHTEVLKEDIVNLTNLEILSYGEDTGLSVLASRDLREVYSFGHMEYDRDTLSKEYFRDLKAGKNPHIPENYFKNDDVHETPALCWSSAAALFFNNWINYAVYQETPFDWENPENDASYFAYL
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.