PharMolix/UniProtQA huggingface dataset:
Protein: TYSY_ECO81
Sequence: MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_XANOM
Sequence: MSKFFRRRKFCKFTAEGVKEIDYKDLNTLRQYLTENGKIVPSRVTGTKSKYQRQLATAVKRSRFLALIPYTDNHDV
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RSMH_THENN
Sequence: MRKYTHYHIPVMVREVIEYLKPEDEKIILDCTVGEGGHARAILEHCPGCKLIGIDVDSEVLQIAEKKLKDFSDRVSLFKASYRDADFLLKTLEIEKVDGILLDLGVSTYQLKGENRGFTFEREEPLDMRMDLESEITAQKVLNELSEEELARIIFEYGEEKRYARRIARKIVENRPLNTTLDLVKAVSEALPSHEIRRRKRHFATRTFQAIRIYVNRELENLREFLLNKAEKLLRVGGRIVVISFHSLEDRIVKEAFRNSRKLRILTEKPVRPSEEEVRENPRSRSARLRAAELVEEGGD
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_HELPG
Sequence: MSKLNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGSTGVGKTEIARRIAKIMELPFVKVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEKLKDKIEEAVIEKIAKKLLPPLPNGVSEEKKQEYANSLLKMQQRIAQGELDNREIEIEVRKKSIEIDSNVPPEILRVQENLIKVFHKEQDKVKKTLSVKEAKEALKAEISDTLLDGEAIKMEGLKRAESSGVIFIDEIDKIAVSSKEGSRQDPSKEGVQRDLLPIVEGSVVNTKYGSIKTEHILFIAAGAFHLSKPSDLIPELQGRFPLRVELENLTEEIMYMILTQTKTSIIKQYQALLKVEGVEIAFEDDAIKELAKLSYNANQKSEDIGARRLHTTIEKVLEDISFEAEDYSGQKVTITKELVQSKLEDLVADENLVKYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_CAMJJ
Sequence: MSKEKEVLLNEEIRADEIRCVGDDGKVYGIISSDEALEIANRLGLDLVMIAADAKPPVCKIMDYGKFRYQQEKKQKEAKKKQKVIDIKEIKLSVKIAQNDINYKVKHALEFLEQGKHVRFRVFLKGREMATPEAGVALLEKIWTMIENEANRDKEPNFEGRYVNMLVTPKKA
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2HB_TRIBO
Sequence: MRTLWIMAVLLVGVEGSVIELGKMILQETGKNPVTYYSAYGCNCGPLGRRKPLDATDRCCFMHKCCYKKLTDSNPIKDSYSYSWENKAIVCKEKNPRLKEMCECDKAVAICFRENMGTYNKKERINTKIFCKKTSEPC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks catalytic activity (PubMed:15955061).  It induces local edema (PubMed:15955061).  Is myotoxic (By similarity).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog Tbo-K49, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GALU_PSEAE
Sequence: MIKKCLFPAAGYGTRFLPATKAMPKEMLPVVNKPLIQYAVEEALEAGLSEIGIVTGRGKRSLEDHFDISYELEHQIRNTDKEKYLVGIRRLIDECTFAYTRQVEMKGLGHAILTGRPLIGDEPFAVVLADDLCLNLEGDSVLKQMVKLYNQFRCSIVAIQEVPPEETNKYGVIAGEMIRDDIFRVNTMVEKPKPEEAPSNLAIIGRYILTPDIFDLIEQTEPGKGGEIQITDALMKQAQDGCVLAYKFKGKRFDCGSAEGYIEATNFCYENLYKTGKAH
What is the function of this protein?
May play a role in stationary phase survival.
What are the official names of this protein?
UTP--glucose-1-phosphate uridylyltransferase, Alpha-D-glucosyl-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, Uridine diphosphoglucose pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 2 family.
Protein: A1AG2_MOUSE
Sequence: MALHMILVMVSLLPLLEAQNPEHVNITIGDPITNETLSWLSDKWFFIGAAVLNPDYRQEIQKTQMVFFNLTPNLINDTMELREYHTIDDHCVYNSTHLGIQRENGTLSKYVGGVKIFADLIVLKMHGAFMLAFDLKDEKKRGLSLNAKRPDITPELREVFQKAVTHVGMDESEIIFVDWKKDRCSQQEKQQLELEKETKKDPEEGQA
What is the function of this protein?
Functions as transport protein in the blood stream.  Binds various ligands in the interior of its beta-barrel domain (By similarity).  Appears to function in modulating the activity of the immune system during the acute-phase reaction.
What are the official names of this protein?
Alpha-1-acid glycoprotein 2, AGP 2, Orosomucoid-2, OMD 2.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: COBT_SHEPW
Sequence: MFNIKPLSSEFEEAIQQKIDTKTKPLGALGDLEGLALQIAKVLGKDNPQINNPKMMVFAADHGIASSGVSIAPSEVTAQMVRNFMAGGAAINVFTRQVGLELEVIDCGVLQPFDSDSGVIDQRLGAGTGPIHKRAAMTLGAVKQGFEMAADRIQLHHQNGCNLIALGEMGIGNTSSAAAIMSVLTGVAASDCVGRGTGIDAATFKRKQMLIEQAVLLHHSELDDPMQVLACIGGFEIVQMTGAILAAAERGMLVVIDGFIASAAALVAVNINSHCRDYMIFSHQSDEKGHYLMLEYMQAKPLLNLGLKLGEGTGAALAFPLIQAAVNFYNQMASFEDAGIEI
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: TSAD_MESH7
Sequence: MKILGIETSHDDASVALFSENKVEILLTISQFELHEQFGGTVPELASREHSRNLAIILEKLLGKNIDFSTIDAIAYTKNPGLIGPLKIGFLFASALSLFFNKPLIPIDHLLGHFWSAAIENDLEFPVLSLLISGGHTQLIFAENKNNLEIIGSTVDDALGEIYDKIGRSLGCGYPGGPKIDLIWQQNNVRNMELIDFSLPKVLENPLDFSFSGLKTQVINYTNNLKENYLFSQKKVVEIAVSFQKTVIKYLKRQLDLALKTKKNVKTITLVGGVAANSEIRKLIKTYENKYKVVIPKKEFCTDNGAMIAKAAQIFLKFNEEK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_SHEDO
Sequence: MATVNQLVRKPRAPKVEKTNVPALNACPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCAGVNTRRQGRSKYGAKRPKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RM07_SCHPO
Sequence: MLGIRKNIRISVNFLQRRTITVKQKLGKNRPLPGWDPNSEYFRPGPTMLNRLQEHLHDTILPDVLAASYRHDIDTALSTDEHTQKDRLPRWIGDNPYYKNRPPQKMRGNKPLLPVKESVNPKNLPSISKVVVSTMHKEALVDKTQLLSTMMAFRSITGLQPEIVYARKDVSPWKLRSGVPVGVKVTLTGESMYTFLSILSELVLPQLHDFKGLSPTSGDQTGNISFGLPSEVMPLFPQIEAVYEMYPHSLPGFNVNITTNSKDTRLARFFVSSLIPFTDGNKEGYVG
What are the official names of this protein?
Probable 54S ribosomal protein L7, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LEPA_PSYWF
Sequence: MTALSNIRNFSIIAHIDHGKSTLADRFIQTCGALQDREMQAQVLDSMDIERERGITIKAQSVTLYYDHPNGERYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAAQGVEAQSVANCYTAVDLGLEVLPVLNKIDLPQVEPERVIQEIEDIIGIEADDAPRVSAKSGLGVDELLEALVERIPAPTGDRDAPLQALIIDSWFDNYLGVVSLVRVRQGSLSKGDKILIKSTMDSHLVTSIGVFTPKPLETGKLEAGEVGFVIAGIKDIHGAPVGDTMTHAKTPDVDLIPGFKQITPQVYAGLFPVDSSDFEKFREALQKLQINDSALFFEPDTSDALGFGFRCGFLGMLHMEIIQERLEREYNLDLITTAPSVIYEIKKKNGEILLIDNPSRLPDPGFVEEFREPIARCHILVPQDYLGNVMTLCMERRGTQVDMRFMGKQVQLIFDIPLGEVVMDFFDRLKSVSRGFASLDYEFDRYEVDKLVKVDVLINGDKVDALAMICHQEQARYRGGQLVEKMKELIPRQMFDVAIQAAIGSQIIARSTVKAMRKDVLAKCYGGDVSRKKKLLSKQKEGKKRMKQVGSVEIPQEAFLAVLQVDNQ
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYFA_CLONN
Sequence: MKEKLQQIKNTALEELNKISNKAELENIRVKYLGKKGELTQILRGMGKLSSQERPVIGKLANEVRGSIEELIEKAVTEIKLKEKEAKLKNEVIDISMPGRKQTVGRKNPLQLTLDSIMDIFISMGFSIEEGPEVEKDYYNFEALNIPKNHPARGEQDTFYINDDVVLRTQTSPIQVRTMENQKPPIKMIAPGKVYRSDSVDATHSPIFYQIEGLVIDKGITFADLKGTLELFTKKMFGEKMQTKFRPHHFPFTEPSAEMDATCFVCGGKGCNVCKNSGWIELLGCGMVHPDVLRNCGIDPEVYSGFAFGFGLDRMVMQKYELDDIRLLYESDMRFLNQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCS_ECO57
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLRNRLWNGIKDIEEVYLNGDLEHGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis (biotin, thiamine, molybdopterin).  Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine, then delivers the sulfur to an acceptor protein such as CyaY, IscU, IscX, MoaD/MoeB, ThiI, or TusA.  Transfers sulfur to acceptor proteins via a transpersulfidation reaction; the flexibility of the persulfide sulfur-carrying Cys-328 allows it to reach different partners docked on the homodimer surface.  May function as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2017_CORGL
Sequence: MAGSSHTIEPEIYRGVSTLDEPSAAWGWHGLKRNTIQLAGWISVLFMLGYNFGNHKGHVETIWLLVITALLVIGLLIHLFEPKLSQVRTITSRNKPVGHVEPDWTYDQATLTGTWGNLTDSQLRSVNIEPSRVAHLRAADSAKELDN
What are the official names of this protein?
Uncharacterized membrane protein Cgl2017/cg2211, P20.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCSH_CLOK5
Sequence: MNFPKELMYTESHEWVKIEGDKALVGLTDYAQSELGDLVFVNLPEEGDEVTAGEVFLDVESVKAASDVYAPLGGVIEEVNEELLDRPGWINEAPYEAWLVKIGEISDREKLLTAEEYEAVVNSEKE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: GLUQ_PSEA7
Sequence: MTSSYVGRFAPTPSGYLHFGSLVAAVASYLDARAVGGRWLVRMEDLDPPREVPGAQRAILETLERYGFEWDGAVERQSERFPAYASVIEQLLRSGLAYACTCSRKQLEDFAGIYPGFCRDAGHARDDAAIRLRVPELEYRFVDRVQGEVCQHLGREVGDFVIQRRDGLYAYQLAVVLDDAWQGITDIVRGADLLDSTPRQLYLQELLGLSQPRYLHVPLIVQPDGHKLGKSYRSPPLPAEQAAVPLTRALRALGQRPPAELAEGSAGEALAWGVAHWDATRIPRRATLPEESL
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: NHAA2_MYCGI
Sequence: MAATPLPPPRRPVFSRGSWAETRRVTEILRKETVGGVILLVAAAAALIWANSPWAEGYFALRDLELGGEWFGLHLNLTLGAWAADGLLAIFFLVVGLELKREFVAGDLRDPSRAALPIAAAVGGMVVPALIFVLVNLNTGDGALRGWAIPTATDIAFAVAVLAVIGTHLPSALRTFLLTLAVVDDLLAITVIAVFYTEDINGLALALAAVPLALFALCVQRGVQKWWVLVPLSVATWVLMHESGVHATVAGVLLGFAVPVRRQATPRGRGPAPSQRVGMAEYFEHRVRPVSAGIAIPVFAFFAAGVSIGGLDGFTRALSDPITLGIVLGLVLGKPIGIVLTTRVLSAVTRANLDASLRWVDVVGMSMLAGIGFTVSLLIGDLAYGLGSERDEFVKIGVLFGSLLAAGVAAVVLLTRNRAYRRIYREETVDEDRDGVPDVYQTRQDRT
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 2, Sodium/proton antiporter NhaA 2.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SHU1_ECOLX
Sequence: MKKYDRGWASLETGAALLIVMLLIAWGAGIWQDYIQTKGWQTEARLVSNWTSAARSYIGKNYTTLQGSSTTTTPAVITTTMLKNTGFLSSGFTETNSEGQRLQAYVVRNAQNPELLQAMVVSSGGTPYPVKALIQMAKDITTGLGGYIQDGKTATGALRSWSVALSNYGAKSGNGHIAVLLSTDELSGAAEDTDRLYRFQVNGRPDLNKMHTAIDMGSNNLNNVGAVNAQTGNFSGNVNGVNGTFSGQVKGNSGNFDVNVTAGGDIRSNNGWLITRNSKGWLNETHGGGFYMSDGSWVRSVNNKGIYTGGQVKGGTVRADGRLYTGEYLQLERTAVAGASCSPNGLVGRDNTGAILSCQSGTWKTSGSLNGSYTNLGSHRGSFSGRNSGGSTLFIYASGGNGGSAGGACANTSRLQGYVGGTLISVNASNNPAYGKTAFISFAVPAGTSYQITSYPTENTSCGAGVFSVFGYQT
What are the official names of this protein?
Shufflon protein A.
Protein: RECA_XYLFM
Sequence: MDENKKRALSVALSQIEKQFGKGSVMRMGDRVIEAVEAIPTGSLMLDLALGIGGLPKGRVVEIYGPESSGKTTLTLQAIAQCQKKGGTAAFIDAEHALDPIYAGKLGVNVDDLLLSQPDTGEQALEIADMLVRSGSIDIMVIDSVAALTPKAEIEGEMGDQLPGLQARLMSQALRKLTGNIKRSNTLVIFINQLRMKIGIMMPGQSPETTTGGNALKFYASVRLDIRRIGAIKKGDEIIGNQTKIKVVKNKLAPPFKQVVTEILYGEGISREGELIEMGVEAKLVEKAGAWYSYGGERIGQGKDNARGYLRENPHLAAKLEADLREKFEPTELSREEGDEDTLEDAM
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MILL1_MOUSE
Sequence: MLLSRNLRALAAIHLWIVYLLLEDLLGTCAEGDNQRLVASAPYQDIEITLEKPRVQAVAEPHTLRYDLMALSLEVPGLPQFLTLRYFDDEPFLPYKKNSSITDSQEPRIKDHLRAETWGRETDDLQEEEEQLKGMLAEITAQNGQNTDLHILQATFGCELQRNGSTRGFWKLGYDGQNFLTFDQKTLTWTVDGPSTQKNKTFWKTRAPRADLVKTFLDDICPAQLQRYLASLRNGLLNTGFPKVIVTFRNYPVGRITLTCRAFRLYTRVATLTWLQYRKPVQQKTFGSETILPSGDGTYQAWVSIRVLPGQESQFSCNLKHGNHNINEPAATEAPVYGARREQPPTSGVGSRVGKSLWSAMTTALVVISWTLSQKLMGPLLWFCSGGFCSFLQCW
What are the official names of this protein?
MHC class I-like protein MILL1, MHC class I-like located near the leukocyte receptor complex 1.
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: RDRP_ROTHK
Sequence: MGKYNLILSEYLSFVYNSQSAVQIPIYYSSNSELETRCIEFHAKCVDNSKKGLSLKPLFEEYKDVTDNATLLSILSYSYDKYNAVERKLVSYAKGKPLEADLTANELDYENNKITSELFQSAEEYTDSLMDPAILTSLSSNLNAVMFWLERHSNDIADANKIYKRRLDLFTIVASTINKYGVPRHNEKYRYEYEVMKDKPYYLVTWANSSIEMLMSVFSHEDYLIAKELIVLSYSNRSTLAKLVSSPMSILVALIDINGTFITNEELELEFSDKYVKAIVPDQTFDELQEMINNMKKIGLVDIPRMIQEWLIDCSLEKFTLMSKIYSWSFHVGFRKQKMIDAALDQLKTEYTKDVDDEMYNEYTMLIRDEIVKMLEIPVKHDDHLLRDSELAGLLSMSSASNGESRQIKFGRKTIFSTKKNMHVMDDIAHGKYTPGVIPPVNVDKPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLLYAKHTREYAEFYSQSNQLLSYGDVTRFLSSNSMVLYTDVSQWDSSQHNTQPFRKGIIMGLDMLSNMTNDPKVVQALNLYKQTQINLMDSYVQIPDGNVIKKNQYGAVASGEKQTKAANSIANLALIKTVLSRIANKYSFITKIIRVSGDDNYAVLQFNTDLTKQMIQDVSNDVRYIYFRMNAKVKALVSTVGIEIAKRYLAGGKIFFRAGINLLNNEKRGQSTQWDQAAILYSNYIVNKLRGFETDREFILTKIIQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQKSGIADEIASSQTFKNYVSKLSDQLLVSKNVIVSKGIAVTEKAKLNSYAPIYLEKRRAQISALLTMLQKPVSFKSNKNTINEILRDIKPFFVTTEDNLPIQYRKFMPTLPDNVQYVIQCIGSRTYQIEDSGSKSSISKLISKYSVYKPSIEELYKVISLREQEIQLYLVSLGVPLVDASAYVASRIYSQDKYKILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEIINYAIKNRAWISVFCNYPKSEMIKLWKKMWSITALRSPYTSANFFQD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).
Protein: PPNP_YERPE
Sequence: MLKFNEYFTGKVKSIGFDSDSIGPASVGVMEKGEYTFSTAKAEEMTVITGSLKVLIPGSPDWQTFMPGETFYIPGESEFNLQVAEASSYLCKYLS
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: PRTT_ASPFC
Sequence: MMHIQTLRKITILDVQDKQRCLSTNQNVPDNVFQLIACWCYFPPFLSIAKIKPLIALKAGISENPVLIGCRRIKMAHCPYSEAMTRTTSVEDVKFEIPAWDNSNVDVADGSGRPESSTSGDTIRPKGRIRRSMTACNTCRKLKTRCDLDPRGHACRRCLSLRIECKLPETAERFQDNASMWSDATAAIPSIEERLISLERSMTEMTSMMRRMMDRSPSISGSSVSMLTRSGITDETASIEGSQSSSFAPRPIRLLQDLQSDFTGEANVLPADSRSLGDLFTKGIIDPKLSQKLIQLFVDHFGIWISVDNPSDIHNELRATDPLLYSTACLLASRYVPGIPLSVIHAMYLQIRHATVNVLWNKTPLKHETLQALALLALWPTAVQKETPMDSWLLSGISINHAIISFDFLNHAPSDLIVDNDMVAKLRVWNALCLTQLQSAIGNARPFHIQQRYLEHCPRLLEHPAATFEDGKIVAEIQLYLIALKLQNFSHRMRLGDFEYEEIERWKMEWAHLLKLSLWYCQLLLYRTAMRFHWESEHLISEILRNSRLILSKFLLVRFPNALAFPDQIYYIVGYAALNLCDFSPMDPLIDQVQTFLLHLSPNEDHIAYRFSYTITELKRRCATGPNPHNVVKGAFGDTRKLSMGQQIPFMNPLMDTMMGEYGGLEHLIPEVPPNSLPDMLTSVAGELQAFRTAIL
What is the function of this protein?
Transcription factor required for protein utilization and degradation.  Regulates transcription of major secreted proteases including a serine alkaline protease (alk1), a metalloprotease (mep), an aspergillopepsin (pep1), a sedolisin (sed2) and two dipeptidyl-peptidases (dppIV and dppV) (By similarity).
What are the official names of this protein?
Transcriptional activator of proteases prtT, Zn(2)-C6 zinc finger-containing protein prtT.
What is the protein family that this protein belongs to?
Belongs to the prtT family.
What are the subcellular locations of this protein?
Nucleus.