PharMolix/UniProtQA huggingface dataset:
Protein: NU2C_MESVI
Sequence: MEFKDLIASLNIDAVLPEAIIICSSLFILIIDLIFQRRANAVLPYMAILGLILSMLSLLFQWNGKEVTAFLGSFQTDSLSIAFRLLIALSSMLCVLLSIEYLENSKKTLSEFLVIFLTATLGAMLLCGSNDILMIFLSLETLGLCSYILTGYMKKDIRSNEASIKYLLIGAASSSILLYGFSLLYGLSHGHIEIHEIAANLIKDQNGNSLASLVALALIIVGISFKIAAAPFHQWAPDVYEGAPTPVVAFLSVSSKAAGLMLATRIMTILFPYIINEWHNIFQILAILSMAIGNIIAISQTNIKRMLGYSSIAQAGFLLVGLLAGNINGYSSMLVYMLIYLFMNLGAFACVILFSLKTGSDQIRDYGGLYLKDPILALCLSICLLSLGGIPPFGGFFGKLYLFWAGWEAGSYLLVFVGLLTSVISIFYYIKIIKMMIIKESPEVSFAIKNYSQKRWSIKDITPIEVSILICVIGTTISGIFVNPIISIAQQTVIDSSWLMAI
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic, NAD(P)H dehydrogenase, subunit 2, NADH-plastoquinone oxidoreductase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: THOP1_HUMAN
Sequence: MKPPAACAGDMADAASPCSVVNDLRWDLSAQQIEERTRELIEQTKRVYDQVGTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC
What is the function of this protein?
Involved in the metabolism of neuropeptides under 20 amino acid residues long.  Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185).  Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185).  Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
What are the official names of this protein?
Thimet oligopeptidase, Endopeptidase 24.15, MP78.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_ENTFA
Sequence: MARIAGVDIPRDKRVVVSLTYIYGIGNTTAKKVLANVGVSEDVRVRDLTNEQTDAIRAEIDKLKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPTRGQNTKNNARTRKGPTKTVAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RR2_CUSGR
Sequence: MTKKYWNINLEDMLEARVHLGHSTQNWNPKMAPYISAKRKGIHIINLTRTARFLSEACDLVFYAASKGKKFLIVGTNNAADEAVARASKRARCHYVNKKWLGGMLTNWSTTETRLQKFRDLRMEQKKGGLNNLPKKEATMLKRKLARLQKYLGGIQYMTGLPDIVIIIDQHKEYTALQECRILGIPTISLIDTNCDPNLSDIAIPANDDAMASIRFILNKLVFAICQGYFSDLRKP
What are the official names of this protein?
Plastid 30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid.
Protein: DRS4_AGASP
Sequence: MAFLKKSLFLVLFLGLVSLSMCEEEKRENEVEEEQEDDEQSELRRSLWSSIKDMAAAAGRAALNAVNGILNPGEQ
What is the function of this protein?
Antimicrobial peptide with activity against Gram-positive and Gram-negative bacteria and fungi (PubMed:31671555, PubMed:31422479).  Has been tested against E. coli (MIC=47. 25-128 uM), S. aureus (MIC=189-512 uM), K. pneumoniae (MIC=189 uM) and C. albicans (MIC>189 uM) (PubMed:31671555, PubMed:31422479).  Probably acts by disturbing membrane functions with its alpha-helical amphipathic structure (Probable).  May penetrate bacterial membranes, but stay at the mammalian membrane surface (Probable).  Shows a weak hemolytic activity (PubMed:31671555).
What are the official names of this protein?
Dermaseptin-SP4, DRS-SP4.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: T4S20_HUMAN
Sequence: MTCCEGWTSCNGFSLLVLLLLGVVLNAIPLIVSLVEEDQFSQNPISCFEWWFPGIIGAGLMAIPATTMSLTARKRACCNNRTGMFLSSLFSVITVIGALYCMLISIQALLKGPLMCNSPSNSNANCEFSLKNISDIHPESFNLQWFFNDSCAPPTGFNKPTSNDTMASGWRASSFHFDSEENKHRLIHFSVFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSKRRSQIV
What is the function of this protein?
Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293).  In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293).  Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).
What are the official names of this protein?
Transmembrane 4 L6 family member 20.
What is the protein family that this protein belongs to?
Belongs to the L6 tetraspanin family.
Protein: MYF5_COTJA
Sequence: RVRARIPGLSSPEGEFPEDFEPRELPPFGAPAPTEPACPEEEEHIRAPSGHHQAGHCLMWACKACKRKSTTMDRRKAATMRERRRLKKVNQAFETLKRCTTANPNQRLPKVEILRNAIRYIESLQELLREQVENYYHLPGQSCSEPTSPSSSCSDAMGRTAAGPVWPARGSSFEAGYCPEMPHAYATEQSGALSSLDCLSRIVDRLSPAEEPGLPLRHAGSLSPGASIDSGARTPGSPPPRTYQAL
What is the function of this protein?
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.  Induces fibroblasts to differentiate into myoblasts.  Probable sequence specific DNA-binding protein (By similarity).
What are the official names of this protein?
Myogenic factor 5, Myf-5, Myogenic factor 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: NDHK_NICTO
Sequence: MNSIQFPLLDRTAQNSVISTTLNDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAVIDAITKLRKKISRELYEDRIRSQRANRYFTTNHKFHVQHSIHTGNYDQRVLYQPPFTSEIPTEIFFKYKNSVSSPELVN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: ACCA_ECODH
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQIAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMQMAERFKMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLGVPVVCTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLADLADLDVLSTEDLKNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2CG1_AMOCU
Sequence: MFTMKKPLLLLFFLGTISLSLCQEERGADEDDGEMTEEVKRGLWNTIKEAGKKFAINVLDKIRCGIAGGCKT
What is the function of this protein?
Antimicrobial peptide active against a variety of Gram-positive and some Gram-negative bacterial strains.  Has antifungal activity against a slime mold isolate.  Has hemolytic activity against human erythrocytes.
What are the official names of this protein?
Palustrin-2CG1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GATDH_CERSP
Sequence: MDYRTVFRLDGACAAVTGAGSGIGLEICRAFAASGARLILIDREAAALDRAAQELGAAVAARIVADVTDAEAMTAAAAEAEAVAPVSILVNSAGIARLHDALETDDATWRQVMAVNVDGMFWASRAFGRAMVARGAGAIVNLGSMSGTIVNRPQFASSYMASKGAVHQLTRALAAEWAGRGVRVNALAPGYVATEMTLKMRERPELFETWLDMTPMGRCGEPSEIAAAALFLASPAASYVTGAILAVDGGYTVW
What is the function of this protein?
Catalyzes the interconversion of galactitol to the rare sugar L-tagatose (PubMed:7551050).  Shows activity with a wide range of substrates, and catalyzes the oxidation of a variety of polyvalent aliphatic alcohols and polyols to the corresponding ketones and ketoses, respectively, and in the reverse reaction, it reduces ketones with high stereoselectivity yielding the corresponding S-configurated alcohols (PubMed:7551050, PubMed:15296184).  Shows high activity with D-threitol, xylitol, 1,2-hexanediol, 1,2-pentanediol, 2-hexanol, L-erythrulose, D-ribulose and acetoin (PubMed:7551050).  Specific for NAD(+) (PubMed:7551050).
What are the official names of this protein?
Galactitol 2-dehydrogenase (L-tagatose-forming), Galactitol dehydrogenase, GDH, GatDH, Galactitol:NAD(+) 5-oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: GATA_NOVAD
Sequence: MTNLTDLGIAAIRDGVARGDFTATEVATAFNAAVEAAQPALNAFIVTTPEEALEAAGKVDADRTAGRPLGKMAGVPIGMKDLFATRGTQTTAASKILEGFMPEYESTVSQKLWDAGAGMLGKLNLDQFAMGSSNETSAFGNVISPWRRPGDTAPLAPGGSSGGSSSAVAARIAPAATGTDTGGSIRQPAAFTGISGIKPTYGRCSRWGIVAFASSLDQAGPMARDVADCAIMLEAMAGFDPKDSTSLDMPVPEWTANLDPDMRGKKVGIPREYRLDGMDPDVARSWEDGIAWLKDAGAEIVEISLPHTKYALPTYYIIAPAEASSNLARYDGVRYGLRDLPEGAGLQDMYAATRAAGFGPEVKRRILIGTYVLSAGFYDAYYTQAQKVRTLISHDFTNAFREVDVILAPTAPSSAFALGEKSADPLEMYLNDVFSVPASLAGLPAMSVPAGLDRNGLPLGLQVIGRAFDEQGVLNAGLALEQRARFSARPAKWW
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: Y853_RICPR
Sequence: MNNAIVLNNVNTNLFKKDIINNFVNNLTKSTCSTIANMLAIDYTLRLNSKPEAEKYIKKCVTRLKSYLGMRVINDDNFSVALELFAIMITYEYENEQNKDNILEQSQNVIAANLVEVYFSDAKITSSEKEKIKNIFKTLLKEKNFDKIINYAESHKKLFKMSVMYAMQKYNNIDQATIYIKKEFNKILDMSLAFTQKCNIFKQTTGKIVGAVCALLVGAISVATAGAAFSIIIVPTLIFAIRYAPALGEKIGEFILNNDNVIKLEQSNIDEFMKTLQNNKENLLSQEKVKKIKNNITVVPPTINSKLIKKVVNNKKNIDRIY
What are the official names of this protein?
Uncharacterized protein RP853.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: C1S_PIG
Sequence: MWCIVLLSLLAWVDAEPTMYGEILSPNYPQAYPNEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIKSGGREEGKLCGQKTSKNPKSAVVEEFQVPYNKLQVIFTSDFSNEERFTGFAAYYVAVDVNECTDFADSPCSHFCNNYIGGYFCSCPPEYFLHEDKKNCGVNCSGDVFTTLIGEVASPNYPNPYPENSRCDYQILLEEGFQVVVTMRREDFDVEPADSGGHCPDSLIFVAGNQQFGPYCGNGFPGPLTIETKSNALNIIFQTDETEQKKGWKFRYHGDPIPCPKEVTANSFWEPEKAKYVFKDVVKITCLDGFEVVQGTVGSTSFYSTCQSNGKWSNSKLRCQPVDCGSPEPIPHGKVEDPEHTLFGSVTRYSCEQPYYYMETDGSEEYRCAGNGSWVNELLGAELPKCVPVCGIPSEPFKGMQRIFGGIITKIESFPWQVFFQNPRAGGALIDEQWVLTAAHVVEGNREPVMYVGSSSVVTSHLANGQMLTAERVFIHPGWEEQDASERKNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYDPSVGDLGLISGWGRTNTKDHVVKLRGAKLPVAPSDKCQEIKGTNPRIGTSSFVFTDNMICAGGRGVDSCNGDSGGAFAMQVPNEETPKFYVAGLVSWGPQCGTYGIYTRVKNYIDWIRETMQQNSAPSVD
What is the function of this protein?
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.  C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity).
What are the official names of this protein?
Complement C1s subcomponent, C1 esterase, Complement component 1 subcomponent s.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: MURG_ALIFM
Sequence: MKNKNKRLLVMAGGTGGHVFPGLAVAKQLQSEGWEIRWLGTADRMEADLVPKHGIEIDFIKVKGLRGQGLKKLIAAPFQILGAISQAKKHIKAWQPDVVLGMGGYVSGPGGIAAWLSGIPVVLHEQNAVAGLTNQWLSKIAKRVFQAFPGAFPNAEVVGNPVREDVCQLPHPKERFAQRTGPIRLLVMGGSQGARILNTTLPEALPQLSHEIEIWHQAGKGSQETVEQAYRDNGIADAKVTEFIDNVAEAYAWADLLVCRSGALTVSEVSAAGVGSIFIPFMHKDRQQALNADHLVQCGAAQMIEQQDLTVQGLVDTLNGLERKQLLDMACNARDAAIIDADVRVANAIKSLAK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HMCS2_PIG
Sequence: MQRLLTPVRQVLRVKRAMQEASFMPPLLPPAAHQRFSTVPAVPVAKADTWPKDVGILALEVYFPAQYVDQTDLEKFDNVEAGRYTVGLGQTHMGFCSVQEDINSLCLTVVQRLMERTQLPWDSVGWLEVGTETIIDKSKSVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWVESSAWDGRYAVVVCGDIAVYPRGNSRPTGGAGAVAMLVGPEAPLALERGLRGTHMENAYDFYKPNATSEYPLVDGKLSIQCYLRALDRCYTLYRQKIEKQWKQAGIERHFTLDDLQFMIFHTPFCKLVQKSLARLMFSDFLLADSDTQSSLYKGLEAFRGQKLEDTYANKDIEKAFQKASLDLFNKKTKPSLYLSLHNGNMYTSSLYGCLASLLSQCSAQDLAGSRIGAFSYGSGLAASFYSLRVSQDASPGSPLEKLVSSVSDLPERLASRKRVSPEEFTEIMNQREQYYHKVNFTPPGDPNSLFPGTWYLERVDELYRRKYARHLV
What is the function of this protein?
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
What are the official names of this protein?
Hydroxymethylglutaryl-CoA synthase, mitochondrial, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CSY3_PSEAB
Sequence: MSKPILSTASVLAFERKLDPSDALMSAGAWAQRDASQEWPAVTVREKSVRGTISNRLKTKDRDPAKLDASIQSPNLQTVDVANLPSDADTLKVRFTLRVLGGAGTPSACNDAAYRDKLLQTVATYVNDQGFAELARRYAHNLANARFLWRNRVGAEAVEVRINHIRQGEVARAWRFDALAIGLRDFKADAELDALAELIASGLSGSGHVLLEVVAFARIGDGQEVFPSQELILDKGDKKGQKSKTLYSVRDAAAIHSQKIGNALRTIDTWYPDEDGLGPIAVEPYGSVTSQGKAYRQPKQKLDFYTLLDNWVLRDEAPAVEQQHYVIANLIRGGVFGEAEEK
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential).  Involved in crRNA production or stability.  The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.
What are the official names of this protein?
CRISPR-associated protein Csy3.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csy3 family.
Protein: TRXB_VIBCH
Sequence: MSNVKHSKLLILGSGPAGYTAAVYAARANLKPVLVTGMQQGGQLTTTTEVENWPGDAEGLTGPALMERMKEHAERFDTEIVFDHINSVDLSSRPFRLTGDSQEYTCDALIISTGASAKYLGLESEEAFKGRGVSACATCDGFFYRNQKVAVVGGGNTAVEEALYLSNIASEVHLVHRRDSFRSEKILIDRLMDKVANGNIVLHTHRTLDEVLGDEMGVTGVRLKDTQSDMTENLDVMGVFIAIGHQPNSQIFEGQLEMKNGYIVVKSGLEGNATQTSIEGVFAAGDVMDHNYRQAITSAGTGCMAALDAERYLDSQGK
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_ROSDO
Sequence: MTDLTPREIVSELDRFIIGQNDAKRAVAVALRNRWRRKQLADDLRDEVYPKNILMIGPTGVGKTEISRRLAKLARAPFLKVEATKFTEVGYVGRDVEQIIRDLVDNAISMTRDHMRDDVKANAHQAAEERVITAIAGEDARESTREMFRKKLKAGDLDDTVIELDVADTSSPFPMMDIPGQPGGNMGMMNLGDIFGKALGGRTTRKKMTVSQSYDILIGEEADKLLDDETVNRAAIEAVEQNGIVFLDEIDKVCAKSDTRGGDVSREGVQRDLLPLIEGTTVSTKHGPIKTDHILFIASGAFHIAKPSDLLPELQGRLPIRVELRALTEEDFVRILTETDNALTLQYTALMGTEEVTVSFTEDGIAALAKIAAEVNQSVENIGARRLYTVMERVFEELSFSAPDRAGEEIIVDAAFVDENLGALAKSTDVSRYVL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPI_CRYNJ
Sequence: MSPSVFKISPGINSYDWGKKGSASLAAQLATTSIPDFSIDEDKAYAELWMGTHPNNPSRLSDNTLLSEHLKSHPELIGSSVSSKFEDCKDGSLPFLFKVLSIGTALSIQAHPDKPLAKKLFDEKPDVYKDPNHKPEMAIALTPFLAFLNFLPLSVLLLHLLTVPELQEFVDSSLTESLASSLGLPTSQPPDTSLFKPTESPATAEQKDILKQIFAALMSADKKLVEEAISKLIKRYQAKRDIKENEKSLVDLALRLNDQYPGDVGVLCVFLLNVVELKRGEAAFLGANEPHAYIEGDIIECMATSDNVVRAGLTPKLRDVDTLVSMLTYEAAPGNKQLLQPTPFQKGDDTTKLYDPPIAEFSVLRTELSKGMKTSHRPVEGPSLCVITEGEGVVRNGNDRSEFVRGDVIFVGAGKEVEWEAIKGLEMFRAYVEA
What is the function of this protein?
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
What are the official names of this protein?
Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZCPW1_HUMAN
Sequence: MMTTLQNKEECGKGPKRIFAPPAQKSYSLLPCSPNSPKEETPGISSPETEARISLPKASLKKKEEKATMKNVPSREQEKKRKAQINKQAEKKEKEKSSLTNAEFEEIVQIVLQKSLQECLGMGSGLDFAETSCAQPVVSTQSDKEPGITASATDTDNANGEEVPHTQEISVSWEGEAAPEIRTSKLGQPDPAPSKKKSNRLTLSKRKKEAHEKVEKTQGGHEHRQEDRLKKTVQDHSQIRDQQKGEISGFGQCLVWVQCSFPNCGKWRRLCGNIDPSVLPDNWSCDQNTDVQYNRCDIPEETWTGLESDVAYASYIPGSIIWAKQYGYPWWPGMIESDPDLGEYFLFTSHLDSLPSKYHVTFFGETVSRAWIPVNMLKNFQELSLELSVMKKRRNDCSQKLGVALMMAQEAEQISIQERVNLFGFWSRFNGSNSNGERKDLQLSGLNSPGSCLEKKEKEEELEKEEGEKTDPILPIRKRVKIQTQKTKPRGLGGDAGTADGRGRTLQRKIMKRSLGRKSTAPPAPRMGRKEGQGNSDSDQPGPKKKFKAPQSKALAASFSEGKEVRTVPKNLGLSACKGACPSSAKEEPRHREPLTQEAGSVPLEDEASSDLDLEQLMEDVGRELGQSGELQHSNSDGEDFPVALFGK
What is the function of this protein?
Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) (PubMed:32744506, PubMed:20826339).  Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity).  Essential for male fertility and spermatogenesis (By similarity).  Required for meiosis prophase I progression in male but not in female germ cells (By similarity).
What are the official names of this protein?
Zinc finger CW-type PWWP domain protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ACTP_SALCH
Sequence: MKRVLTALAAALPFAAHAADAISGAVEHQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAVHPKGTAIMSPGGLVQDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAYKDAAGALIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFRKGATEREELKVSKITVLVLGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLLTAVVLMILGPTIWVQILGHEKAIFPYEYPALFSISVAFLGIWFFSATDNSAEGNREREQFRAQFIRSQTGFGVQQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SELO_MYCSS
Sequence: MTNLSLDGRFARELPEMAVRWKAEEAPDPRLLVLNDELASGLGLDADWLRSPDGVRLLVGNSVPDGATPVAQAYAGHQFGGFAPRLGDGRALLLGELVDGDGRMRDVHLKGSGHTPFARAGDGLAAVGPMLREYLVSEAMHALGIPTTRSLAVVATGRPVRRESVLDGAVLTRVASSHLRVGSFQYAAVTGDTDLVRRLAGHAIARHHPEVAGAADPYLGLFEAVCSAQAQLIARWMLVGFVHGVMNTDNMTISGETIDYGPCAFMDVYDPETVFSSIDSWGRYAYGNQPSIAAWNLARFAETLLPLFDDDIDRAITLAQNALGAFGRHYEGALTAGMQAKLGLTGVDGPAVAPLLDELLKLLQDNHIDFTSFFRALGLAARGDNEPVRGLFVDLAGFDAWLDSWRALGPDGAAMDRVNPVYIPRNHLVEEALTAAAAGDMEPFETLLDAVTGPFDERPGLQRYAEPAPEAFGRYRTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: NU5M_PELSU
Sequence: MPNLQLILKTILITELLILALSALMTMLPPILNKLTWDPEKAMTTTFRLSLTSILIHILIEEPSSISSLYSPTMLNLAMSIKIDYYSLIFISIALFITRAILQYTKWYMASDRDLKKFSMFLLLFLMSMIMFIAANNFFPMLVGWGTMGLMSYLLISWWHGRTEATTSGLQAILYNRLADIGFILTFSWCITYMSSLDLNTFFATSTLVTGVPILGMLMAAMGKSAQFGMHPWLPAAMEGPTPVSALLHSSTMVTAGVYLLIGMHPILSQTQGFSEACLTMGAATALYASFKALLQNDLKKIIAFSTLSQLGFMMATVGLNHPNLAFMHLCMHAFFKAMMFLCAGSISHALFGEQDIRKMSGMIKVTPITASCFTLSTLALAGFPFLTGFFSKDLIIETILLSKINMLWATMLLISTMFTAIYSLRMTLRILTGTPWYNDLLTYEENPTCTKPIMKLALASIVTGSLFSLFTPPIYTPLQTMPPTIKLAALTLTFMSAFLAMYLISLANNKPLPKNTIQNHMLQTAKDLKIITHRHLMAKLLKASQKTALQILDNHWKLKAGPKYIEKTQIPMSMKTSTQSGLIKTYFMAFLVTFVIILYIMLFY
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.