PharMolix/UniProtQA huggingface dataset:
Protein: RISB_METRJ
Sequence: MVAHTRADSAPKPTDPALAGARILVVEARYYDAIADELLAGALAAIEAADARATVVTVPGALEIPAAAAILLDTGAYDAVVALGCVIRGETGHYDIVAGESARALMDLSVQRRVPLGNGILTVETEAQALARARVAEMNKGGGAAEAALGVLALKRMADGARPR
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: CRCB_THEMA
Sequence: MIELDYLTIAFGGAIGAVLRYLVSRTINSLLPFSYIPLGTIIVNSVGSFFLSFLMFAAIEKVPLSKEAILFFGTGLLGAFTTFSTFTYETLSLIEESPARGVAYALANLLFAFTCAYFGMILGRGKV
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS3_ACET2
Sequence: MGQKVNPHGLRIGIIKDWDTKWYANDKNFSEYLVEDFKIRKFIKNKLYSAGISRIEIERAANKVKINVHAAKPGLIIGKGGAGIEELRKQLEKMTQKNILINITEIKVPELDAQIVAENIASQLEKRISFRRAMKQAMARAMRLGAKGIKTAVSGRIAGAEIARTEHYHEGTIPLQTLRADIDYGFAEANTTYGKLGVKVWIYKGEVLPAVKKDKGRKEEISNVNA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PUR7_PSYA2
Sequence: MQKQEMLYKGKAKSVYETEDNDLLILHFRDDTSALDGKRIEQLARKGVVNNRFNAFIMQKLADAGIETHFEKQLSDDEVLVKRLDMIPVECVVRNFAAGSLVRRLGLEEGQALTPPTYELFYKDDALGDPMVNESISISLGWATDAQLAKMKELSHQVNEVLTALFDAGDLILVDFKLEFGVFHDRIILGDEFSPDGCRIWDKATKKKLDKDRFRQSLGDVIEAYEEVASRIGVPLS
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RIMP_POLNS
Sequence: MKEQQVISAELENLGYSLVEIEREAGGLLRVTIENPDYERLITVLDCEKVSHQLSYTLPVENIPYERLEISSPGLDRPVKSAADFQRFAGMEVDLKLRVAAGNRKNFRGELQGLLSGELNSPDAKFGLVFEGADGQSSQLEFSLAEVDKTRLVPVIDFKGRKS
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_GLUOX
Sequence: MRHDWTRDEVEALISLPFPELMYRAQTLHRRYFDPTKVQISTLLSIKTGGCPEDCAYCPQSALHEKSVKAERLMAVESVIKEARAAKKAGAGRFCMGAAWRTPKDHDLDTVCEMIEGVKSLGLETCVTLGMLDAQQTERLKKAGLDYYNHNLDTSEEFYGSIISTRTYQQRLDTLSNVRDAGINVCCGGIVGMGEDLSDRAGLLMTLANLPKHPESVPINLLVRVEGTPLGEAEAVDPITFVRIIATARIMMPESHVRLAAGRENMTDEAHALCFLAGANSIFCGEKLLTTPNPAEHRDRQLLSALGMSPMVQSEAEMGTMRPAVTEDAVCEMAVS
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RSSA_CAEBR
Sequence: MSSGAAHSALTEEDVMKLLATQAHLGSTNLNFQMQQYVYKRRFDGPNIINVKKTWEKLLLAARAIAAVENPADVVVVSARPYAQRALLKFAAHTGATAIFGRFSPGCLTNQIQKTFKEPRLLVISDPRIDHQAVTEASYVGVPVISFVNTESPLKLIDIGVPCNNKGERSIGLMWWMLAREILILRGKISRQTGFVLDGKEIMPDLYFYRDPTETEKEETGAHAEVAETQEFQQQPDIDFTAQGGKVEDWAAETATWTNEGKTAADEWATGAQTQSNW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein SA.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAGK_STAEQ
Sequence: MRKRARIIYNPTSGKELFKRVLPDALIKLEKAGYETSAYATEKIGDATFEAERALESEYDLLIAAGGDGTLNEVVNGIAEQPNRPKLGVIPMGTVNDFGRALHLPSDIMGAIDVIIDGHTTKVDIGKMNNRYFINLAAGGKLTQVSYETPSKLKSIVGPFAYYIKGFEMLPQMKAVDVRIEYDDNIFQGEALLFLLGLTNSMAGFEKLVPDAKLDDGYFTLIIVEKANLAELGHIMTLASRGEHTKHPKVIYAKAKSINISSFTDMQLNVDGEYGGKLPANFLNLEQHIEIFTPKDVFNEELLENDTITDITPDKQ
What is the function of this protein?
Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid.  Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway.
What are the official names of this protein?
Diacylglycerol kinase, DAG kinase, DAGK.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family.
Protein: SPOT_SPICI
Sequence: MDRDIKYEEVLAQIKLYIKDEATLKEIQKAYEYAEEKHHGQVRNSGARYIIHPLWTTFFLAQWRMGPKTLIAGLLHDVLEDTPATFEELQELFGIEIANLVEGVTKVSYFAKENRTQIKAQYLRKLYLSMAKDIRVIIVKLADRLHNLKTIGYLKPERQQIIARESLEIYSAIAHRLGMKAVKQEIEDISFKIINPVQYNKIVSLLESSNKERENTINQKIEELKKILITEKKMSVKVYGRSKSIYSIYRKMNQFGKNFDDIHDILAVRIITNSVDDCYKVLGFVHQHYTPLNNRFKDYIATPKHNLYQSLHTTIVADDGLIFEVQIRTEEMDELAEQGVAAHWRYKEGENYDIAKKQKDIDERLDIFKRILDLENISVQERDEIQQEVYKPDHLMEQIIQNDIFSSLIYVLTPNGKVVTLPFGSTVLDFAYKIHSEIGEKTIGAKINGLFSPISTVLKSGDVVDIKTAATQKPNHSWLVVSKTSSALEKIKKYLKKELVEVTSDAKSVNLEKIKQTKSQIEEYIAKKDLKWKLVNSETQLERLHAINFNNIEDFLLDVANDEYTLEEAINLVYLDHETSQNEKILKKLQDKQYKKAQLKDDIIVQGISNIKVVISQCCLPIPYEDITGYVSKAEGIKVHLKTCRNIQSGDKQDRQVEVSWNEAVCKNKQYDCAIRIEAIDRPALLVDVTKVLSHLNASVQMMSANVSGDLMNLTIKTIIKVSNADRLQQIRSSLLTIPDIKVVERVMM
What is the function of this protein?
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.  This enzyme catalyzes the degradation of ppGpp into GDP.  It may also be capable of catalyzing the synthesis of ppGpp (By similarity).
What are the official names of this protein?
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase, Penta-phosphate guanosine-3'-pyrophosphohydrolase, (ppGpp)ase.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: RL23_METHJ
Sequence: MILKYPYATEKASMIVERDGQLQFIVDRKASKGQIKVAIEKMFDQPVTRVRTLMNNRGEKKAMVSFSNPKAAEEILSRLGIM
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: CLPC_STAAW
Sequence: MLFGRLTERAQRVLAHAQEEAIRLNHSNIGTEHLLLGLMKEPEGIAAKVLESFNITEDKVIEEVEKLIGHGQDHVGTLHYTPRAKKVIELSMDEARKLHHNFVGTEHILLGLIRENEGVAARVFANLDLNITKARAQVVKALGNPEMSNKNAQASKSNNTPTLDSLARDLTVIAKDGTLDPVIGRDKEITRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQAIVNNEVPETLKDKRVMSLDMGTVVAGTKYRGEFEERLKKVMEEIQQAGNVILFIDELHTLVGAGGAEGAIDASNILKPALARGELQCIGATTLDEYRKNIEKDAALERRFQPVQVDEPSVVDTVAILKGLRDRYEAHHRINISDEAIEAAVKLSNRYVSDRFLPDKAIDLIDEASSKVRLKSHTTPNNLKEIEQEIEKVKNEKDAAVHAQEFENAANLRDKQTKLEKQYEEAKNEWKNAQNGMSTSLSEEDIAEVIAGWTGIPLTKINETESEKLLSLEDTLHERVIGQKDAVNSISKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESMFGDDDAMIRVDMSEFMEKHAVSRLVGAPLGYVGHDDGGQLTEKVRRKPYSVILFDEIEKAHPDVFNILLQVLDDGHLTDTKGRTVDFRNTIIIMTSNVGAQELQDQRFAGFGGSSDGQDYETIRKTMLKELKNSFRPEFLNRVDDIIVFHKLTKEELKEIVTMMVNKLTNRLSEQNINIIVTDKAKDKIAEEGYDPEYGARPLIRAIQKTIEDNLSELILDGNQIEGKKVTVDHDGKEFKYDIAEQTSETKTPSQA
What is the function of this protein?
Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpC.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpC subfamily.
Protein: MURI2_BACSU
Sequence: MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSKGKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINKCTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKIIKYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLADRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase 2.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: LEXA_SALTI
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVLEIVSGASRGIRLLQEEEDGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPSADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFTPIVVDLREQSFTIEGLAVGVIRNGEWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: NEF_HV2G1
Sequence: MGASGSKKHSKHSQRLRERLLRAHGGGYVQQCNASGGEYSQSQEGSGKGQKSPSCEGQQYRQGDFMNTPWRTPAIEGQKKLYKQQNMDDIDSSDDDLVGVPVTPRVPLRAMTYKLAVDMSHFIKKRGLDGMFYSRDRHRILDLYLEKEEGIIPDWQNYTHGPGVRYPMCFGWLWKLVPVDVSQEAEDDETNYLTHPAQTSRHDDEHGETLLWRFDPTLAYDYKAFILHPEEFGHKSGLPEKEWKAKLKARGIPYS
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Associates with the inner plasma membrane through its N-terminal domain.
Protein: SYME_ECOK1
Sequence: MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAIDVKVMEGCIVLTAQPPAAEESELMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
What is the function of this protein?
Involved in the degradation and recycling of damaged RNA.  It is itself a target for degradation by the ATP-dependent protease Lon.
What are the official names of this protein?
Endoribonuclease SymE.
What is the protein family that this protein belongs to?
Belongs to the SymE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD2_CAEEL
Sequence: MGVPKTQQSAQPATQSAGPTETLARGIRAIFIGPPGSGKGTQAPAFAQKYFSCHLATGDLLRAEVASGSEFGKELKATMDAGKLVSDEVVCKLIEQKLEKPECKYGFILDGFPRTSGQAEKLDEILERRKTPLDTVVEFNIADDLLVRRITGRLFHIASGRSYHLEFKPPKVPMKDDLTGEPLIRRSDDNEETLRKRLVQYHQMTVPLVDYYKKHGVHVAVDAAKPMTDVKAHIDQVFAKFTQKKERVSFV
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase, Lethal protein 754.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: KDSB_BRUAB
Sequence: MLQTMKTLTLIPARLGSTRLPNKPLADICGKPMIVHVADRAAAAKLGRTVIATDSEEIFKVVAAHGHEAIMTRGDHESGSDRIYEALAKLDPSGEIDAVVNVQGDLPTIDPDTIRRALLPLEDGPADIATLGVEITVEEEKTNPNVVKIVGSPLAGNRRLRALYFTRATAPYGEGPLYHHIGLYAYRRSALERFVKLGPSPLEKREKLEQLRALEAGMRIDVEIVKTVPLGVDTQADLDRARTFCSQAGTI
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_PSEPG
Sequence: MRIGHGYDVHRFCDGDFITLGGVRIPHKYGLLAHSDGDVLLHALSDALLGAAALGDIGKHFPDTDPQFKGADSRALLRHVVGIVRAKGWKVGNVDATIVAQAPKMAPHIETMRQLIAEDLQVELDQVNVKATTTEKLGFTGREEGIAVHSVALLLPA
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RHO_STRRD
Sequence: MTIETTTKKRPRAARPPRPRESDAYLETVAGLLDVRDKTGYIRTHGYLPGVDDVRVPHAQIRQYGLRPGDHVVATTRKPYERLAEVESVNGSTDWRNRPDFADMTPIHPRERLRLETESVTSRVIDLFAPIGKGQRGLIVAPPKAGKTMVLQDLAAAITRNHPDCHLMVVLVGERPEEVTEMRESIHGEVAASTFDRPDRDHTALAELAVERAKRLAESGHDVVVLLDSLTRLGRAYNNLAPGGGRTLAGGLDAAALLPPRRFFGAARNLRDGGSLTILATALVETGSRMDDNLFEEFKGTGNMELRLSRALADKRLYPAVDLDASGTRREEILLDPQEHQLTWRLRRTLGGLEKQQALELLTDRLRETPSNAAFLQQVRQTT
What is the function of this protein?
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
What are the official names of this protein?
Transcription termination factor Rho, ATP-dependent helicase Rho.
What is the protein family that this protein belongs to?
Belongs to the Rho family.
Protein: AROE_AZOSB
Sequence: MDRYAVVGNPIAHSKSPQIHAAFAHQTGEALGYEAILAPLDGFVDTVLAFRAVGGRGMNVTVPFKLEAHALATRLTPRAAAAGAVNTLAFGGPETPDDILGDNTDGAGLVRDLTVNLGCPLHGRRVLLLGAGGAARGALLPLLEQAPAALTIANRTAAKAVELAAGFAAGHPGVAIDGGGFDALAGRRFDVVINATAASLADQAPPLPAGIYAEGALAYDMMYGRGDTPFLAAARADGAGRLADGLGMLVEQAAESFLLWRGVRPDTAPVLADLRARLAAA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: IF2P_CALMQ
Sequence: MSENYRAPIVVVVGHVDVGKTLLLDKIRNTMVAYREPGMITQHIGLSYLPWPIIEKYAAPVIERYRLKGKVWVKGFLMVDTPGHAAFSNLRRRGGSVADLAILVIDLTRGFEEQTYESLILLKSRNIPFVVAANKVDRIYGWKPIPNASILDSYNAQDEETQGRLEEALANIIMDFNKQGFEAERFDRITDFSRQVPIVPTSAVTGEGIPDLLVLMAGLTQRLVKDRLRLVGGPGKGVVMEVKEEKGLGTTMDVVLYDGVMRKGDTIVAMGLNGPVVTRIRMMVMPKPLDEMRDPEDKYMHINEVEAAAGVKVIADGLDDVVPGSSVYVVQGDPKPYIDEVVKDAASVKIETDQIGVVAKADTLGTLEAMVLYLRSQGIPVRKADIGPVTRRDIIDASVVRRKNPLYGVVLAFNVKVPKEVEEEAKVQLVTIFQNNILYRLVEEFTKWFNEEKSRLIESELSKYVRPGKIAIIPGYVFRRSDPAIVGVEVLGGLIKPGYRLVKANGKEVGVIMQIQDKGKPIQVAKKGMSVAISIEGNVIVGRHIKEGDVLYVNVPLEHAVKLIMQYKDHLSSDEVEVLEEFMKLRSTWKAQAQ
What is the function of this protein?
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes.  Seems to function along with eIF-2.
What are the official names of this protein?
Probable translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Protein: RL24_METCA
Sequence: MRRIKKGDQVIVIAGKDKGKKGLVLSVLSGDKLVVEGVNLVRKHQRPNPMRGVTGGIVEKAMPIHSSNVALFNAAINKGDRVGFRLLADGRKVRFYRSTNELIDA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: LPOA_YERP3
Sequence: MLSSTFVRSKAGLVPVILAALILAACTGDAPQTPPPVNIQDEASANSDYYLQQLQQSSDDNKADWQLLAIRALLREAKVPQAAEQLSTLPANLSDTQRQEQQLLAAELLIAQKNTPAAADILAKLEATQLSANQKVRYYQAQIAANQDKATLPLIRAFIAQEPLLTDKAHQDNIDGTWQSLSQLTPQELNTMVINADENVLQGWLDLLRVYQDNKQDPELLKAGIKDWQTRYPQNPAAKNLPTALTQISNFSQASTAKIALLLPLSGPAQVFADAIQQGFTAAQNGSAVTASVPVTPNVTESSPTDTAAVVSDDTPATLPAPVTPPVVTNAQVKIYDTNTQPLAALLAQAQQDGATLVVGPLLKPEVEQLSATPSTLNILALNQPEASNNSPNICYFALSPEDEARDAAHHLWEQQKRMPLLLVPRGALGERIAKAFADEWQKQGGQTVLQQNFGSTTELKQSINSGAGIRLTGTPVSVSNVAAAPASVTIAGLTIPAPPIDAPVVSTSSSGNIDAVYIIATPSELTLIKPMIDMATSSRSKPALFASSRSYQAGAGPDYRLEMEGIQFSDIPLMAGSNPALLQQASAKYANDYSLVRLYAMGIDAWALANHFSEMRQIPGFQVKGVTGDLTASSDCVITRKLPWLQYRQGMVVPLA
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
What are the official names of this protein?
Penicillin-binding protein activator LpoA, PBP activator LpoA.
What is the protein family that this protein belongs to?
Belongs to the LpoA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: ALR1_ECOL6
Sequence: MQAATVLINRRALRHNLQRLRELAPASKLVAVVKANAYGHGLIETARTLPDADAFGVARLEEALRLRAGGITRPILLLEGFFEADDLPTISAEHLHTAVHNEEQLVALENAELKEPVTVWMKLDTGMHRLGVLPEQAEAFYQRLSQCKNVRQPVNIVSHFARADEPQSGATEKQLDIFNTFCEGKPGQRSIAASGGILLWPQSHFDWARPGIILYGVSPLEDGTTGADFGCQPVMSLTSSLIAVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPVILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  Provides the D-alanine required for cell wall biosynthesis (By similarity).
What are the official names of this protein?
Alanine racemase, biosynthetic.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: PDXS_CLONO
Sequence: SRMSDPKMIKEIIDAVSIPVMAKVRIGHVVEAQILQAIGIDYIDESEVLTPADDLFHINKKEFNVPFVCGARNLGEALRRIGEGACMIRTKGEAGTGNVIEAVRHMRTIQSQIRKLKVMPKEELMIAAKELGAPYDLVEYVRENGKLPVINFAAGGIATPADAALMMQLGCDGVFVGSGIFKSENPAKRAKAIVEAVKNYNNPLKIAEVSEGLGEAMTGLEIDKLDVTFAER
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: DNAA_CERS1
Sequence: MTNETWVQVREGLLKRVGRNNFVTWIEPLRLMGLDEGVARFEVPTLFFGDWVQRNFADHIRMRLTEAGSPVERLEFAVSNTPRAPLKEVKAAAPAASPARARPAPPEEDLRGAPLDARFTFDSFVVGKPNELAHAAARRVAEGGPVTFNPLFLYGGVGLGKTHLMHAIAHDLQKRQPGARVLYLSAEQFMYRFVQALREREILGFKELFRSVDVLMVDDVQFIAGKDSTQEEFFHTFNALVDQNKQIVISADRAPGEIKDLEERIKSRLQCGLVVDLHPTDYELRLGILQQKADFYREQYRGLVIADGVLEFLAHRITTNVRVLEGALTRLFAFASLVGREITLDLAQDCLADILRASDRKVTIEEIQRKVAEHYNIRLSDMIGPKRLRTIARPRQVAMYLAKQLTPRSLPEIGRRFGGRDHTTIMHGVRKIEELMATDSQLADDLQLLRRLLQA
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YLII_ECOLI
Sequence: MHRQSFFLVPLICLSSALWAAPATVNVEVLQDKLDHPWALAFLPDNHGMLITLRGGELRHWQAGKGLSAPLSGVPDVWAHGQGGLLDVVLAPDFAQSRRIWLSYSEVGDDGKAGTAVGYGRLSDDLSKVTDFRTVFRQMPKLSTGNHFGGRLVFDGKGYLFIALGENNQRPTAQDLDKLQGKLVRLTDQGEIPDDNPFIKESGARAEIWSYGIRNPQGMAMNPWSNALWLNEHGPRGGDEINIPQKGKNYGWPLATWGINYSGFKIPEAKGEIVAGTEQPVFYWKDSPAVSGMAFYNSDKFPQWQQKLFIGALKDKDVIVMSVNGDKVTEDGRILTDRGQRIRDVRTGPDGYLYVLTDESSGELLKVSPRN
What is the function of this protein?
Aldose sugar dehydrogenase with broad substrate specificity.  The physiological substrate is unknown.  Can oxidize glucose to gluconolactone.  Can also utilize D-arabinose, L-arabinose and 2-deoxy-glucose.  Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose.  It may function to input sugar-derived electrons into the respiratory network.
What are the official names of this protein?
Aldose sugar dehydrogenase YliI, Asd, Soluble aldose sugar dehydrogenase YliI.
What is the protein family that this protein belongs to?
Belongs to the PQQ oxidoreductase GdhB family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: MAMK_MAGSA
Sequence: MSEGEGQAKNRLFLGIDLGTSHTAVMSSRGKKFLLKSVVGYPKDVIGLKLLGRPYVVGDEAFEMRSYLDIRYPLQDGVLSEISDRDIEVARHLLTHVVKSAEPGPNDEICAVIGVPARASAANKALLLKMAQEVVHTALVVSEPFMVGYGLDKLINTIIVDIGAGTTDICALKGTVPGPEDQVTLTKAGNYVDERLQNAILERHPELQMNVNVACAVKEQFSFVGTPTEVASFEFRAAGKPVRADVTEPVKIACEALMPDIIESIETLLRSFQPEYQATVLQNIVFAGGGSRIRGLAAYVKEKLRPFGDANVTCVKDPTFDGCRGALRLAEELPPQYWRQLGDVSGS
What is the function of this protein?
Protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that organize magnetosomes into long chains running parallel to the long axis of the cell (Probable) (PubMed:21883528, PubMed:28790202, PubMed:23204522, PubMed:24957623).  Turnover of MamK filaments is probably promoted by MamK-like, which provides a monomer pool (PubMed:24957623).  Forms twisted filaments in the presence of ATP or GTP (PubMed:20161777, PubMed:23204522, PubMed:27391173).  Serves to close gaps between magnetosomes in the chain (PubMed:26884433).  Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation (PubMed:20471399).  Expression in E. coli yields a filament in the cell's longitudinal axis; the protein nucleates at several sites and one extremity of the filament is located at the cell pole (PubMed:17085581, PubMed:20161777).
What are the official names of this protein?
Actin-like protein MamK, Magnetosome cytoskeleton protein MamK.
What is the protein family that this protein belongs to?
Belongs to the FtsA/MreB family. MamK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Magnetosome membrane; Peripheral membrane protein. Note=Tagged protein forms straight lines extending along most of the cell associated with its inner curvature, in the correct position to be filaments that are seen associated with magnetosomes (PubMed:17085581, PubMed:16373532, PubMed:20471399, PubMed:27481925, PubMed:21883528). Colocalizes in filaments with paralog MamK-like (PubMed:24957623).