PharMolix/UniProtQA huggingface dataset:
Protein: MIAA_PSECP
Sequence: MGTPPVIAVVGPTGSGKSDLAVNLALELDGEVINADAMQFYRGMDIGTAKITPAERRGIPHHLLDILDVTQEASVSDFQDQARRLIGDIHSRGKRAILVGGSGLYVRAALDILEFPGTDPALRRRLEDDLAAHGTATLRARLQDVDPVSAERLSDDRRIIRALEVHELTGRPFSSFMPRREYFQPAVQVGLSVDRAALHERLAARVHAMVDSGLQAEVRRLDGLGLRTGKTACRALGYSQFLQVLDGSATVAEAAESTIVATRQFARRQLTWFRADPRITWIDWQDPDLVARAAGLCSQ
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RECA_SHEHH
Sequence: MKTDPNKEKALNAVLSQIEKQFGKGSIMKLGEDRSMDVETISTGSLSLDVALGAGGLPMGRIVEIYGPESSGKTTLTLEVIAAAQKQGKTCAFIDAEHALDPIYAKKLGVDIDNLLCSQPDTGEQALEICDALTRSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRTGAIKDREEVIGNETRVKVVKNKIAAPFKQAEFQILYGQGINSTGELVDLGVQHKLIEKSGAWYAYKGNKIGQGRANAGKYLIENPEVSDEIETTLRAMLLGNGEKIAPDAADTAGDNVDLETGEVF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA_BURP6
Sequence: MNAPHTPHLNEAEAAAAVEANAAELGRRALTRREQKEAYENNKLFKRLVRQVGQAIGDYNMIEHGDKVMVCLSGGKDSYALLDILLRLRERAPIDFDIVAVNLDQKQPGFPEHVLPEYLTKIGVPFHIENQDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVAGELGATKIALGHHRDDIVQTLLLNMFYGGKLKGMPPKLQSDDGKNIVIRPLAYAKETDLEKYAELREFPIIPCNLCGSQPNLKRAEMKALIRDWDKRFPGRVDNMFNALANVVPSHLMDARLFPFAGLRATGEADPNGDIAFDEDPCGTDASAPGGAKSVSIVQFDDL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_BRUMB
Sequence: MPDTTPQLRLYNTLTRTKEAFAPIDAKNVRMYVCGPTVYDFAHIGNARPVIVFDVLFRLLRHVYGAQHVTYARNITDVDDKINARAARDYPDLPFNEAIRKVTESTNAQFQADVTALGNLQPTVQPRATEHMDEMRAMIDRLVQRGVAYVAQDHVLFSPSAMNARKGPRYGALARRSLDEMLAGARVDVASYKRDEMDFVLWKPSKKGEPGWPSPAGIETLGRPGWHIECSAMSMAKLLEPFGGGLKCDDPERNQFDIHGGGIDLVFPHHENEIAQSCCALGTERMANIWMHNGFLQVEGQKMSKSLGNFITIRDVLNDGLPQLGEWGDNTVRDRWAGLAARLSMLQTHYREPINWTAQRLAESADELHRWYGLLRDEGFGAPEKLSHASAVAAALCDDLNSWAAITALRQAFKVRDVAALGEGMALMGLLDPYFVTASDVPIFARADVDASAIAARIAERLNFINAKNWAEADRIRDELLQEGVQLKDSKDPATGERITTWDVVG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEA49_ARATH
Sequence: MGSSKDSASVTNISVEEHFSVSQSSPGGQFVGPTEEISTAAEALIGRSTTLTEALKAASMNVGHKPVETTDVAAIKEVETRAIGGDIESEGGVTAVASKAVARNQKIGKDNEKTNLGDVIAEIDVKVTRDREVTSEDAEAVIRAELNHSPFNNIIPGGVAESVAAAYKLNHDPSSL
What is the function of this protein?
LEA proteins are late embryonic proteins abundant in higher plant seed embryos.  The function of those proteins is not known.
What are the official names of this protein?
Late embryogenesis abundant protein 49, LEA 49.
What is the protein family that this protein belongs to?
Belongs to the LEA type SMP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PSAA_ATRBE
Sequence: MIIRSPEPEVKILVDRDPVKTSFEEWARPGHFSRTIAKGPDTTTWIWNLHADAHDFDSHTSDLEEISRKVFSAHFGQLSIIFLWLSGMYFHGARFSNYEAWLSDPTHIGPSAQVVWPIVGQEILNGDVRGGFRGIQITSGFFQIWRASGITSELQLYCTAIGALVFAALMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLSWAGHQVHVSLPINQFLNAGVDPKEIPLPHEYILNRDLLAQLYPSFAEGATPFFTLNWSKYADFLTFRGGLDPVTGGLWLTDIAHHHLAIAILFLIAGHMYRTNWGIGHGLKDILEAHKGPFTGQGHKGLYEILTTSWHAQLSLNLAMLGSLTIVVAHHMYSMPPYPYLATDYGTQLSLFTHHMWIGGFLIVGAAAHAAIFMVRDYDPTTRYNDLLDRVLRHRDAIISHLNWACIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPVFAQWIQNTHALAPGATAPGATASTSLTWGGGDLVAVGGKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPERGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSVSDQGVVTHITGGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLFFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPATQPRALSIIQGRAVGVTHYLLGGIATTWAFFLARIITVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: HDEA_BRUA2
Sequence: MIKALFNKNTALAAVAILALSGGAMAESAKTHKTDMAKKKVSELTCEDFNGLEESFKPTVVGWVVGFNKKGKEEDAVIDVDGIETVTPAIIEACKQEPKASFWKKAEAELKKVF
What is the function of this protein?
Required for optimal acid stress protection.  Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins (By similarity).  Contributes to acid resistance.  Not required for wild-type virulence in the BALB/c mouse model.
What are the official names of this protein?
Probable acid stress chaperone HdeA.
What is the protein family that this protein belongs to?
Belongs to the HdeA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: LNAC_ASPFN
Sequence: MIGEQYTSIITGFKSALAVSCIAVSLFLLSPWIAYARLPSSIKSPIKAKGPLSALRACLNEISAGAKTSTRGYELYSKKGQSFAMLNINFRPQVILPPEHVRWLVTQPEDILSHAKASDDADALGYIWPLFDASALHSFSKVLQIDLTRNVTQTEKDVLEEVQHIMDELVGQTESWKEVNMVQAFERIMYQATQRVYVGLPLCRDSTYMGYVKGYARSLGTAMVFAAQLTPWPLRQVTALLAGLPVYYYVLRVRSYLSPLFKERMERLKEKGGTQDDNLEGEPRNLITWMSDGVLSGVGPKSISPSEMVTWLGILALLPTDNLWTTCTNVLLDLLSSESEHAYLHTIREEARTVFASSKESGKPVSHGLHHIDSAIRESLRMNSLSPRSLHRQVVRRGGVVLPDGQKVPTGTWLCVLSGNIQRDEDYYEDAQTYKPFRFVPKLTEAGGDKAPLLPLTNEKYLTFGYGRHACPGRWFSFQVMKIVIAYILANYDIQPLEKRPDNIVFADLNIPHLSHIIRIKRMT
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the lna gene cluster that mediates the biosynthesis of diastereomeric piperazines.  Lna and lnb clusters encode sets of enzymes that produce overlapping sets of previously undescribed metabolites such as piperazinomycin-like metabolites or morpholine (PubMed:23281040).  The lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure (PubMed:23281040).  One primary function of the non-canonical nonribosomal peptide synthetases lnaA and lnbA consists in the reduction of L-tyrosine (PubMed:23281040).  The presence in the clusters of tailoring enzymes such as the oxidoreductases lnaB, lnbB, lnaE or lnbE, as well as of the cytochrome P450 monooxygenases lnaC, lnaD, or lnbC, might explain formation of various diastereomeric piperazines (PubMed:23281040).
What are the official names of this protein?
Cytochrome P450 monooxygenase lnaC, Lna diastereomeric piperazines biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ERA_STRP3
Sequence: MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVINKIDKVHPDQLLEQIDDFRSQMDFKEVVPISALEGNNVPTLIKLLTDNLEEGFQYFPEDQITDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEETDKVHIRATIMVERDSQKGIIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNEKEY
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: RET3_BOVIN
Sequence: MVRKWALLLPMLLCGLTGPAHLFQPSLVLEMAQVLLDNYCFPENLMGMQGAIEQAIKSQEILSISDPQTLAHVLTAGVQSSLNDPRLVISYEPSTLEAPPRAPAVTNLTLEEIIAGLQDGLRHEILEGNVGYLRVDDIPGQEVMSKLRSFLVANVWRKLVNTSALVLDLRHCTGGHVSGIPYVISYLHPGSTVSHVDTVYDRPSNTTTEIWTLPEALGEKYSADKDVVVLTSSRTGGVAEDIAYILKQMRRAIVVGERTVGGALNLQKLRVGQSDFFLTVPVSRSLGPLGEGSQTWEGSGVLPCVGTPAEQALEKALAVLMLRRALPGVIQRLQEALREYYTLVDRVPALLSHLAAMDLSSVVSEDDLVTKLNAGLQAVSEDPRLQVQVVRPKEASSGPEEEAEEPPEAVPEVPEDEAVRRALVDSVFQVSVLPGNVGYLRFDSFADASVLEVLGPYILHQVWEPLQDTEHLIMDLRQNPGGPSSAVPLLLSYFQSPDASPVRLFSTYDRRTNITREHFSQTELLGRPYGTQRGVYLLTSHRTATAAEELAFLMQSLGWATLVGEITAGSLLHTHTVSLLETPEGGLALTVPVLTFIDNHGECWLGGGVVPDAIVLAEEALDRAQEVLEFHRSLGELVEGTGRLLEAHYARPEVVGQMGALLRAKLAQGAYRTAVDLESLASQLTADLQEMSGDHRLLVFHSPGEMVAEEAPPPPPVVPSPEELSYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVQLVWQKLVDTAALVVDLRYNPGSYSTAVPLLCSYFFEAEPRRHLYSVFDRATSRVTEVWTLPHVTGQRYGSHKDLYVLVSHTSGSAAEAFAHTMQDLQRATIIGEPTAGGALSVGIYQVGSSALYASMPTQMAMSASTGEAWDLAGVEPDITVPMSVALSTARDIVTLRAKVPTVLQTAGKLVADNYASPELGVKMAAELSGLQSRYARVTSEAALAELLQADLQVLSGDPHLKTAHIPEDAKDRIPGIVPMQIPSPEVFEDLIKFSFHTNVLEGNVGYLRFDMFGDCELLTQVSELLVEHVWKKIVHTDALIVDMRFNIGGPTSSISALCSYFFDEGPPILLDKIYNRPNNSVSELWTLSQLEGERYGSKKSMVILTSTLTAGAAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTDLYLTIPTARSVGAADGSSWEGVGVVPDVAVPAEAALTRAQEMLQHTPLRARRSPRLHGRRKGHHRQSQGRAGSLGRNQGVVRPEVLTEAPSGQKRGLLQCG
What is the function of this protein?
IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
What are the official names of this protein?
Retinol-binding protein 3, Interphotoreceptor retinoid-binding protein, IRBP, Interstitial retinol-binding protein, Protein 7S.
What is the protein family that this protein belongs to?
Belongs to the peptidase S41A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
Protein: PF23A_XENLA
Sequence: MLETTMGEASPEDPPLNLKSLSQPPQKRSRTVEDFNRFCSFVLAYAGYIPPPAKEERAWTPPSSVSPHRTEESDGWDSPDPPQLPIPSDPRQPPASSDISTIETFVMKAKSQGGGGGNSENVEGPVGSGEQAQVKKGSRRKRRQRHRGGVTMSDTDTDEEERGERLAGSLPAPQLPPSAESSRDGGGSSSDADTQVMDEDIMVESGDDSWDLVTCYCEKPFAGRPMIECNICCTWVHLSCAKIRKSNVPDVYYCQKCRGGKGSGGTAPKGEP
What is the function of this protein?
Acts as a negative regulator of autophagy.
What are the official names of this protein?
PHD finger protein 23A.
What is the protein family that this protein belongs to?
Belongs to the PHF23 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: Y1146_PASMU
Sequence: MRILAAGSLRQPFTLWQQALIQQYQLQVEIEFGPAGLLCQRIEQGEKVDLFASANDVHPRSLQARYPHIQLVPFATNRLCLITKKSVITHHDENWLTLLMSPHLRLGVSTPKADPCGDYTLALFSNIEKRHMGYGSKLKEKAMAIVGGPDSITIPTGRNTAEWLFEQNYADLFIGYASNHQSLRQHSDICVLDIPDEYNVRANYTLAAFTAEALRLVDSLLCLTCGQKYLRDCGFLPANHT
What are the official names of this protein?
Uncharacterized protein PM1146.
Protein: SECB_BURO0
Sequence: MSDVENQPFFNIQRVYLKDMSLEQPNSPAIFLEQDMPSVEVEVDVKADRLAESVFEVVVSGTVTAKVKDKVAFLIEAKQAGIFDIRNIPDEQLDPLVGIACPTILFPYLRSNIADAITRAGFPPIHLAEINFQALYEQRLAQLQQQAGAAAGAPNGAPNGTTLN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
Protein: GATB_LISIN
Sequence: MNFETVIGLEVHVELKTNSKIFSSAPAHFGAEPNTNTTVVDLGMPGVLPVLNKRAVEYGMKAAMAINCEIAEHTKFDRKNYFYPDNPKAYQISQFDKPIGEHGWIEIEVGGKKKKIGITRLHLEEDAGKNTHTSHGYSLVDINRQGTPLIEIVSEPDIRSAEEAYAYLEKLKSIIQYTGVSDVKMEEGSMRCDANISIRPIGQEEFGVKTELKNLNSFNNVRKGIEYEEKRQAEVLKSGGIIEQETRRFEEATGKTSLMRIKEGSDDYRYFPEPDLVDLFIDDAWKERIRAEIPELPDKRQIRYINDLGLPAYDAMVLTLTKEMSDFFEATLAAGADAKQASNWLMGEVSAYLNAEQKELHDTGLTPENLAGMIKLIEAGTISSKIAKKVFRELAQNGGDAEQVVKDKGLVQISDEGALRTIIGEILDNNEQSIIDYKNGKDRAVGFLVGQVMKATKGQANPPMVNKILLEEMNKR
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: RGS17_CHICK
Sequence: MRKRQQSQNEGTSAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVRNEDRGDNAGRPTHTTKMESIQVIEECQNPTADEILSWAQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEKARLIYEDYISILSPKEVSLDSRVREVINRNLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKSLVESITGSTSET
What is the function of this protein?
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity).  Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.  Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities.  Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
What are the official names of this protein?
Regulator of G-protein signaling 17, RGS17.
What are the subcellular locations of this protein?
Membrane. Synapse, synaptosome. Nucleus. Cytoplasm.
Protein: RL2_LACJO
Sequence: MAIIKYKPTTNGRRNMTSSDFAEITKKKPEKTLLESQSHTAGRNSYGHITVRHRGGGHKQKYRIIDFKRNKDDVKAVVKAIEYDPNRTANIALLHYTDGIKAYILAPKGLKVGAVVESGPDADIKPGNALPLSAIPAGTEIHNIELKPGKGGQLVRSAGTVAQVLGNDGKYTLVRLQSGEVRKILSTCRATIGSVGNEQHSLIQLGKAGRSRWLGKRPQSRGSVMNPNDHPHGGGEGKAPVGRPQPMTPWGKKSRGIKTRNSKARSEKLIIRHRKGNK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CD3E_CANLF
Sequence: MQSRNLWRILGLCLLSVGAWGQDEDFKASDDLTSISPEKRFKVSISGTEVVVTCPDVFGYDNIKWEKNDNLVEGASNRELSQKEFSEVDDSGYYACYADSIKEKSYLYLRARVCANCIEVNLMAVVTIIVADICLTLGLLLMVYYWSKTRKANAKPVMRGTGAGSRPRGQNKEKPPPVPNPDYEPIRKGQQDLYSGLNQRGI
What is the function of this protein?
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.  When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.  All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.  Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.  In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development.  Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E.  Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
What are the official names of this protein?
T-cell surface glycoprotein CD3 epsilon chain.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: UPPP_SYNS3
Sequence: MTPDPGLLEACWRDFVLGVVQGLTEFLPISSTAHLKVVPVLAGWGDPGLSVTAVIQLGSIVAVIAYFRADLAGVLKGISGAFRRGQWREPEARLGIAMLIGTLPILIAGLCIKLYWPGYATSSLRSVPAIAVVSIVMALLLGFAELLGPRLKQLNQVDGRDGLVVGLAQVFSLIPGVSRSGSTLTASLFDGWKRADAARFSFLLGIPAITIAGLVELKDAFSGSSAGGVLPVFVGICSAAVVSWLAIDWLIKYLESHSTRIFVVYRLLFGVLLLVWWSGSASN
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: 3S13_LATLA
Sequence: MKTLLLTLVVVTIVCLDLGYTRRCFNHPSSQPQTNKSCPPGENSCYNKQWRDHRGTITERGCGCPTVKPGIKLTCCQSEDCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin OKI-01/OKI-19.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CYB_SACPA
Sequence: MAFRKSNVYLSLVNSYTIDSPQPSSINYWWKMGSLLGLCLVIQIVTGIFMAMHYSSNIELAFSSVEHIMRDVHSGYILRYLHANGASFFFMVMFMHMAKGLYYGSYRSPRVTLWNVGVIIFILTIATAFLGYCCVYGQMSHWGATVITNLFSAIPFVGNDIVSWLWGGFSVSNPTIQRFFALHYLVPFIIAAMVIMHLMALHIHGSSNPLGITGNLDRIPMHSYFIFKDLVTVFLFMLILALFVFYSPNTLGHPDNYIPGNPLVTPASIVPEWYLLPFYAILRSIPDKLLGVITMFAAILVLLVLPFTDRSVVRGNTFKVLSKFFFFIFVFNFVLLGQIGACHVEVPYVLMGQIATFIYFAYFLIIVPVISTIENVLFYIGRVNK
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS3_YERE8
Sequence: MGQKVHPNGIRLGIVKAWNSTWYANTKEFADNLDSDFKVRQFLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: ENLYS_BPPRD
Sequence: MQYTLWDIISRVESNGNLKALRFEPEYYQRRMERGDWDNSIIQNIRAANKCSLGTARMIYCSSWGAVQIMGFNLYLNGAFNLSVAHFMENEAYQVNEFRRFLLKNGLTEYTPERLASDKAARVKFAKVYNGAESYADLILQACQFYGVK
What is the function of this protein?
Endolysin involved in host peptidoglycan digestion after permeabilization of the cytoplasmic membrane by holin.  Involved in host cell lysis and liberation of progeny phages.  Displays strong lytic activity against chloroform-treated Gram-negative cells.
What are the official names of this protein?
Endolysin, Beta-1,4-N-acetylmuramidase, Lysozyme, Lytic enzyme, Muramidase, Protein P15.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 24 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Note=May be associated with the viral membrane via P20 and P22.
Protein: HLDE_YERPY
Sequence: MKVTLPDFRRAGVLVVGDVMLDRYWYGPTSRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGAVARLVGLTGIDDAARALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGALNSVQPMIQLARKANVPVLIDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQGMTLLQLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGTSTVSPIELENAIRGRAETGFGVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQRMVVLGALEAVDWVVPFEEDTPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGRG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: RL22_FERNB
Sequence: MQTIIKREGLKRSKFHAKRKETLATLPKYEARAVARFVRISPRKARSVINSIRGKNVSEAFNLLEFSSKKAARIVYNVLKSAVANATNNLGLSEENLYVAACYVNDGPRMKRVWPRGRGRADIIQKRMSHITVIVRDREKENETKAK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: NFIL3_XENTR
Sequence: MQLRKMPTIKREQECADSRNNMENILVLSSNIPDMSESMDSSNDMLYSEGAPAKNKNSSCRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDMVLENKLIALGEENASLKTELLSLKLKFGLISSASYAQEIQKVTTSTAMYFQEYSSSKPNVMSYNSDHEHSVMTSSCISVIKHSPQSSLSDVSEASSVEHVQPSTVQSNCRSTDINFQRIKQEPMERENFSRDAREDSNTFQGSIYTNYIGNTFSGYSHSPPLLHINRSSSNSPRTSEADEGVVGKTSDGEDEQQVPKGPIHSPVELKNGHTTIIKVPEVNSSALPHKLRIKAKAMQIKVEALESELNSTQKLTLPIDMSSKRHLQLEKHNSETMVHSSLSPLSVQVTNIQDWPLKPGQWHHRELDKIPSVCKTSGIVDIKDNVFKASESESLYLKQGIANLSAEVATLKRLIVTQEICASNSS
What is the function of this protein?
May act as a transcriptional regulator of a number of proteins of the circadian clock.
What are the official names of this protein?
Nuclear factor interleukin-3-regulated protein.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. NFIL3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PCF6_ORYSJ
Sequence: MEAAVGDGEGGGGGGGRGKRGRGGGGGEMVEAVWGQTGSTASRIYRVRATGGKDRHSKVYTAKGIRDRRVRLSVATAIQFYDLQDRLGFDQPSKAIEWLINAASPAIDTLPSLDPAAFAAIPHAAADAAPTRRRSQQQQQQLSNKSGCSSTSETSKGSDKEVTVASAPAQAASFTELLIAGVAASSAGGGAIGNGADCVGIAHPGKGGAEGASTYGFSAASSFGDAPPIGMVPAPPFNFSAPGADMAAHYSLAQDQLAAPPPPAGGDYNLNFSMSSGFLGANRGTLQSNSPSNMSGHHHHHHQQQLQRLDGSTISFLLGHAAAAAHPAASEGQITSTAALQLWDGFRHSGMKEKSKN
What is the function of this protein?
Transcription activator.  Binds the promoter core sequence 5'-GGNCC-3'.
What are the official names of this protein?
Transcription factor PCF6.
What are the subcellular locations of this protein?
Nucleus.