PharMolix/UniProtQA huggingface dataset:
Protein: TRUA_METPE
Sequence: MRLAFQLSYDGNQFRGSQLQPAYRTVEGELITACQRVQLFDDPCKAGFALAGRTDRGVHARGQVGAFSTPFPERAVEALNGQLSPDLWCNGFAEVPPSFHPRFDAISRTYRYFFADWPLDIRAMDQAAAALIGTHDFSRLARVREKSPIRTVKSARVFQDRGIPVFEVTAHTYLWHMVRCMAAALLLIGTHEREPELMERLLSGKCRRNPPAAPADGLVLWDVDCGVTFTPTEPDPRSRDWIGSARREAMVRERIIGLLDRSGVDRRGKEPGDDSGRDLL
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: SCG1_HUMAN
Sequence: MQPTLLLSLLGAVGLAAVNSMPVDNRNHNEGMVTRCIIEVLSNALSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEAGAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQREDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQEESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRASEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRVQENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSSHHTAEKRKRLGELFNPYYDPLQWKSSHFERRDNMNDNFLEGEEENELTLNEKNFFPEYNYDWWEKKPFSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFYDSEEPVSTHQEAENEKDRADQTVLTEDEKKELENLAAMDLELQKIAEKFSQRG
What is the function of this protein?
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
What are the official names of this protein?
Secretogranin-1, Chromogranin-B, CgB, Secretogranin I, SgI.
What is the protein family that this protein belongs to?
Belongs to the chromogranin/secretogranin protein family.
What are the subcellular locations of this protein?
Secreted. Note=Neuroendocrine and endocrine secretory granules.
Protein: RECU_STAAN
Sequence: MNYPNGKPYRKNSAIDGGKKTAAFSNIEYGGRGMSLEKDIEHSNTFYLKSDIAVIHKKPTPVQIVNVNYPKRSKAVINEAYFRTPSTTDYNGVYQGYYIDFEAKETKNKTSFPLNNIHDHQVEHMKNAYQQKGIVFLMIRFKTLDEVYLLPYSKFEVFWKRYKDNIKKSITVDEIRKNGYHIPYQYQPRLDYLKAVDKLILDESEDRV
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: N4B3B_XENLA
Sequence: MAAAQTFSANCDPVNFHNLQSYPSESVTYSCKMGNVSSLMEKQDFPNEGFNLDFRPFPEPSCKRGLHQKEFLSYLNITKKEGKNNKKFPSGLGFRREHSLQAEENDYPVFYHKDHRGTEFSKSSLPERGHSDKSRFGPSALKSNVKAFMSIQSLHQSTNKLSKSNGSLNTLGCVGSPPCRGPLQPSNSHSNNPSESGNDEDDDSLSDSKQNSINSLNSYSPSFTVARGQISASLGHINHIGGSLDRASRGLRDTMAGEKGTLSCRNMATLSRLQCSGEPPPPYEYSESVEDVARQLEKRLQEKGMEAQQLRRNASDNDDPFTQVFEDKRRLWMEELDELKQMYMSKLQQISQQALRSQRALQLQLYKVQQEKKRLQEELNSLQGENEELRQKQSQSDNSGPNLEDSKWEISQKAGEISFLKQQLRDSQAEINLKLGEVVSLKVQLREAKALVKEKEKESAELSDCLQALEDVKSQTPVDLPRDSSDTIDVERLRAELMLERRQNEAQILIFETERKVWKEEKDKVLRYQKEIQSSYLEMYQRNQALERQVLELRQGVGQSLSSPASWMDTVET
What is the function of this protein?
Plays a role in axon and dendrite arborization during cranial nerve development (PubMed:24044555).  Also important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (PubMed:28104388).
What are the official names of this protein?
NEDD4-binding protein 3-B.
What is the protein family that this protein belongs to?
Belongs to the N4BP3 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Cell projection, axon. Cell projection, dendrite. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites.
Protein: MURG_BUCA5
Sequence: MIPKKIIIMAGGSGGHVFPGLTIARYLIEKGWLVNWIGTKNSIESRIIPTYGIKIHYISIKGLRNTSLKNLIISPIYILRAYYAVKKIIKTWSPDIVLGMGGYVSGPGGVASWNCNIPLLLHEQNKIAGITNKWLSRISTKNMQASPGVLRNAEVVGNPVCQSIIKVPNPINRFKNRTGLLRVLVIGGSQGSSILNRILPKVSFLLKEKIIFWHQTGNYELEKTKKKYNKLRLNQNLITSFIKNIASAYEWADLIICRSGALTVSEISIVGLGAIFIPYPHKDKQQHRNAEDLELIGAAKIIDQSNLNTKLIVNILNSLDRDKLFIMAKKAHSLGVRDAIFNIFNVINKISKKT
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS5_STAS1
Sequence: MARREEAKEFEERVVTINRVAKVVKGGRRFRFTALVVVGDKNGRVGFGTGKAQEVPEAIKKAVEAAKKDLVVVPRVEGTTPHTITGRFSSGSVFMKPAAPGTGVIAGGPVRAVLELAGITDILSKSLGSNTPINMVRATINGLKNLKNAEDVAKLRGKSVEELYN
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: SYS_XANOM
Sequence: MLDPALLRQHPADLAERLRSTRGFALDTAKLESLESERKHMQVRTQELQSLRNSKSKAIGQAKAKGEDVAALMAEVAGVGDELLHSHGRLTVVQHELEKIYAVIPNLPHADVPLGKSEADNVEQSRWGTPRQFDFPVKDHVELGAPNGWLDGETAVKLSGARFTVLRGPIARLHRALAQFMLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFRIYENEYEGHTDEETGESFYTPTGGVDPDPAYYLIPTSEVPLTNIVRDEIIDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACAPEDSDAEHQRMTRCAEVVLEQLGLPYRKVLLCTGDMGFSAIKTYDLEVWLPSQNTYREISSCSNCGDFQARRMQARWRNPVSGKLELLHTLNGSGTAVGRAMIAVMENYQNADGSIDVPQVLRPYMGGIERIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPS3_MOUSE
Sequence: MVRLYNLHPFGSQQVVPCQWEPEQVCCGGSDALFVAAGCKVEAFAVQGEELCRQRCAFSTLGRVLRMAYSEAGDYLVAIEEKNKTIFLRAYVNWRSKRSDNSRVCIRMVGHNVEASFCESFRDQMSIIEMPMSEAPLCFSCCPVKGDLLVGCTNKLVLFTLKYDIINEEFSILNFERSLIIHIDNITPVEISFCVGYVAVMSDLEVLLLKLESDPIHGESVDHHPQETSNPLKEAEGVSNETSQLESEDFVICLKPMELIGEKCEQSGISVKLESTGLEDEKVKYLRVRHLLYRRFAPDISSYVLSDNIKLHSLQLLPIHQSGFHPDENDLSPKKEMPNLFCFFSLPHVGYLYMVVKSVELMSVYWYPEKSQQAVLTPQFLHVITSQSLQCFTVRCSAAVAHEEDLYMDTTLKACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTKAEPEAIPERRESPKKLISRKDASVRSGTPHVAEAAWNLYLVNTTAPVQLYKEMVDYSNSYKTVKTESCLHLLSEAHLLVRAALMDGSQLEPAEKAELLEAFKESCGHLGDCYSRLTTEQSHLALPYYKMSGLSLAEVLARVDWTEESESQKYERGLVFYINHSLYENLDEELSKELAAKVAQIFHMAEPKQLPHVLSSPSMKNIDPLTALHYLRKLDSCGVSPVLVTLTKAAVALKMGDLDMYRNEMKSHSEMKLVYGFILEPRLLIQQWKGQIVPTELAIDLKETQPGLLVASVLGLQKNDKIGIVETDSFFKVLCGKDEDAVPQLLIDFWEAQLVACLPNVVLEELFFKLISQYVWRLSERRCPDTVPLRTAEDLINACSHYGLVNPWVHVLTTSDSLADKNYTDDLLKLQSLICSPSLDVASIIPFLEPLSEDTVAGLSTHALCHTRLQEYEQCIDTLLERCPEAVIAYANQELKEDHWILWWKKLLPELCQRVKSGGERSHLHLSLLKETLSVIAVGLDLRDFLNVLPEDGAAAFFLPYLLFCSRKKSLT
What is the function of this protein?
Involved in early stages of melanosome biogenesis and maturation.
What are the official names of this protein?
BLOC-2 complex member HPS3, Cocoa protein, Hermansky-Pudlak syndrome 3 protein homolog.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol.
Protein: AP1S2_ARATH
Sequence: MIHFVLLVSRQGKVRLTKWYSPYAQKERSKVIRELSGVILNRGPKLCNFVEWRGYKVVYKRYASLYFCMCIDQEDNELEVLEIIHHYVEILDRYFGSVCELDLIFNFHKAYYILDELLIAGELQESSKKTVARIISAQDQLVEVAKEEASSISNIIAQATNR
What is the function of this protein?
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE).  The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).
What are the official names of this protein?
AP-1 complex subunit sigma-2, Adaptor AP-1 19 kDa protein, Adaptor protein complex AP-1 sigma-2 subunit, Adaptor-related protein complex 1 sigma-2 subunit, Clathrin assembly protein complex 1 sigma-2 small chain, Clathrin assembly small subunit protein AP19-2, AtAP19-2, Sigma 2 subunit of AP-1 clathrin, Sigma-adaptin 2, Sigma2-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SEPF_SYNJA
Sequence: MEGQEDYQLLYEGRRSQPAPEEQEASALPRGRRQRGVEAGEGSVGREEARGHRRSQHRDRLGGGSMGSNVIGLPGVNPPTSEVVVLEPRSFDEMAQVIQYLRERKTVIMNLTLMDPAEAQRSVDFVAGGTYAIDGHQERIGENIFLFTPSTVTVSTPSSQGMPPLQRPLQSPTPLWPSGYEHLQAVGQH
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: TBX3_MOUSE
Sequence: MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEDVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFEERHKKETSDESSSEQAAFNCFAQASSPAVSIVGTSNLKDLCPSEAESDAEAESKEEHGPEACDAAKISTTTAEEPGRDKGSPATRAQLFPAEPSRARDTARLDKASPDSRHSPATISSSTRVPGADERRSPGREGPVATKVDEARAIPAKDAFAPLSVQTDATAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPGQFAMGGAFSSMAAGMGPLLATVSGASTGVSGLESTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASTAAASSSVHRHPFLNLNSMRPRLRYSPYSIPVPVPDSSSLLATALPSMASAAGPLDGKAAALAASPASVAVDSGSELNSRSSTLSSGSVSLSPKLCSEKEAATSELQSIQRLVSGLEAKPDRSCSGSP
What is the function of this protein?
Transcriptional repressor involved in developmental processes (By similarity).  Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity).  Probably plays a role in limb pattern formation (By similarity).  Required for mammary placode induction, and maintenance of the mammary buds during development (PubMed:16222716).  Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (PubMed:27720610, PubMed:16222716).  Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (PubMed:27720610).  Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (PubMed:33795231).  Acts as a negative regulator of PML function in cellular senescence (By similarity).
What are the official names of this protein?
T-box transcription factor TBX3, T-box protein 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: VATA_HALVD
Sequence: MSQATQDSVREDGVIASVSGPVVTARGLDARMNDVVYVGDEGLMGEVIEIEGDLTTIQVYEETSGVGPGEPVESTGEPLTVDLGPGMMDAIYDGVQRPLDVLESKMDSAFLDRGVDAPGIDLDEKWEFEPTVSEGDEVAPGDVVGTVPETVTIEHKVMVPPDFGGGEVVAVEEGEFSVTEAVVELDSGEEITMHQEWPVRQARPAAEKKTPREPLVSGQRILDGLFPIAKGGTAAIPGPFGSGKTVTQHQLAKWADADIVVYVGCGERGNEMTEVIEDFPELDDPKTGNPLMARTCLIANTSNMPVAARESCIYTGITIAEYYRDMGYDVALMADSTSRWAEAMREISSRLEEMPGEEGYPAYLAARLSEFYERAGYFTTVNGEEGSVSVIGAVSPPGGDFSEPVTQNTLRIVKTFWALDADLAERRHFPAINWNESYSLYQEQLDPWFVENVEDDWAEERQWAVDVLDEENELQEIVQLVGKDALPEDQQLTLEIARYLREAYLQQNAFHPTDTYCSPEKTYGILTAIHAFNDEAFKALEAGVPVEEIQAIEAAPRLNRIGVQEDWEAYIEDLKAEITEQLRELY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: SFSA_SULIL
Sequence: MNERDSRNQIGDLPFRVKEGFSVYEFIEQLYEAHVVERINRFLVKVTFNGKEFLAHLHDPGRLKDLIYPGNLVLIRETKGYKTKFSITAAYSNSRFVVLDSRLHNIIASKFLPEAYEKEIKVGNSRIDFKYDNTYLEVKGCTLVENEIAYFPDAPTERGRRHLKELRELMKKGFNSILLILVMRDDAKCFLPNEKTDPKFSIEFWNSINEGLNVNIKTFKLVGNKIIYVRDIPLCKTNLT
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: CAIC_ECOHS
Sequence: MDIIGGQHLRQMWDDLADVYGHKTALICESSGGVVNRYSYLELNQEINRTANLFYTLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLREESAWILQNSQACLLVTSAQFYPMYQQIQQEDATQLRHICLTDVALPADDGVSSFTQLKNQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHIDCQCTAAMAAFSAGATFVLVEKYSARAFWGQVQKYRATITECIPMMIRTLMVQPPSANDRQHRLREVMFYLNLSEQEKDAFCERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRAGFCYEAEIRDDHNRPLPAGEIGEICIKGVPGKTIFKEYFLNPKATAKVLEADGWLHTGDTGYCDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFRFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIRKNLK
What is the function of this protein?
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.  Also has activity toward crotonobetaine and gamma-butyrobetaine.
What are the official names of this protein?
Crotonobetaine/carnitine--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: SAMD7_HUMAN
Sequence: MAVNPLLTPTGQQTIPLIPSPFGPPTVDRDVLPSTVAPTDPRQFCVPSQFGSSVLPNTNMANVLSSRIYPGWGILPPESIKAVARRNEMIQRHHTARTEMEMYAIYQQRRMEKINPKGLAGLGIPFLYGSSVPAAPAAYHGRSMLPAGDLHFHRSTLRNLQGNPMLAATAPHFEESWGQRCRRLRKNTGNQKALDSDAESSKSQAEEKILGQTHAVPYEEDHYAKDPDIEAPSNQKSSETNEKPTTALANTCGELEPTHRKPWGSHTTTLKAKAWDDGKEEASEQIFATCDEKNGVCPPVPRPSLPGTHALVTIGGNLSLDEDIQKWTVDDVHSFIRSLPGCSDYAQVFKDHAIDGETLPLLTEEHLRGTMGLKLGPALKIQSQVSQHVGSMFYKKTLSFPIRQAFDQPADTSPLLDPNSWSDTMNIFCPQDTIIPKGIERGSMRN
What is the function of this protein?
Involved in the regulation of gene expression in the retina.  It functions as a negative regulator of CRX-controlled genes.
What are the official names of this protein?
Sterile alpha motif domain-containing protein 7, SAM domain-containing protein 7.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: FLIR_PECCC
Sequence: MLTFNSWDMVNWVSQFFWPFVRILALISTAPVFNERAIGNRVKIGLGVLITLLVAPYLPLNTTPIFSVAGVWLLIQQILIGVTLGLSMQLAFAAIRHAGELIGLQMGLAFATFFDPTGGPNMQVVARFLNILAILLFLTFDGHLWMISLLADSFYTLPISANPIISHAFLALARAGGLIFINGLMLALPIITLLLTINLALGMLNRVAPQLSIFVVGFPITLTVGIMTLGLLLPLIPPFAEHLFSEVFDLLADILTQLSSS
What is the function of this protein?
Role in flagellar biosynthesis.
What are the official names of this protein?
Flagellar biosynthetic protein FliR, Flagellar biosynthetic protein MopE.
What is the protein family that this protein belongs to?
Belongs to the FliR/MopE/SpaR family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Protein: NS1_I56A3
Sequence: MDSNTVSSFQVDCFLWHIRKRFADQKMGDAPFLDRLRRDQKSLKGRSSTLGLDIESSTLAGRQIVKRILKEESDSEPKGTITSVPTSYYLTDMTLEEMSRAWFMLIPNQKRVGSLCIRMDQAIMDKEITLKANFSVVFNKLETLTLLRAFTDDEAIIGEILPIPSLPGHTNEDVKNAIEILIGGLEWNNNTVRISEILQRFTWRNSNENGGFLLSPKQKQKMEGTTGPEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: RS12_LEPBP
Sequence: MPTINQLIRIGREDQKKRTKSPALKACPQRRGVCTRVMTFTPKKPNSALRKVARVRLTTGIEVTAYIPGEGHNLQEHNVVLIRGGRVKDLPGVRYHIIRGTLDTLGVDKRRKGRSKYGAKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: MSRA_CHRVO
Sequence: MEKAILGGGCFWCLEAAFSQLKGVERVVSGYCGGHTDSPDYRQVCSGDSGHVEVVEISYDPALIDYATLLQVFFAVHDPTTLNRQGHDVGTQYASAIFYLDETQRECARRVIAQLDAEQIFDAPIVTRVESAPRFHPAEDYHQNYYAQNQQQNYCQLVISPKLAKIRRRFSHLLQN
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: THAP1_XENTR
Sequence: MVQSCSAYGCKNRYDKDKPISFHKFPLKRPLLCRKWEAAVRRADFKPTKYSSICSDHFTADCFKRECNNKLLKDNAVPTIFAHTEIKKKSGKAVKKEQLPAEPEPVPSVPEVDPAIGLLLPPLYTPSHIAVICDHNYTVEDTVHQRRRIQQLEEQVDKLRKKLKIANQKCRRQERSLEKLEREVSEYREAKGSGYVIFPGNYYEVLNENEYKELAPEITYKEIIL
What is the function of this protein?
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression.  Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).
What are the official names of this protein?
THAP domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the THAP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: APT_BURVG
Sequence: MPHSSSGAPLDPVAFIHSQIRTVPDWPQPGVMFRDITTLLQSPKALRILVDLFVERYVDAKLDYVAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYKTCSESYDLEYGSATVEIHEDACRPGDRVIIMDDLIATGGTMMAGRNLLQRLGAVVVEGAAIIDLPDLGGSTLLRNAGLPIYTVTEFAGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANE_STRZT
Sequence: MPQISKEALIEQIKDGIIVSCQALPHEPLYTEAGGVIPLLVKAAEQGGAVGIRANSVRDIKEIKEVTKLPIIGIIKRDYPPQEPFITATMKEVDELAELDIEVIALDCTKRERYDGLEIQEFIRQVKEKYPNQLLMADTSIFEEGLAAVEAGIDFVGTTLSGYTSYSPKVDGPDFELIKKLCDAGVDVIAEGKIHTPEQAKQILEYGVRGIVVGGAITRPKEITERFVASLK
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: CARA_SYNR3
Sequence: MDGLLVLADGTVFRGQGFGAKGTAIGEVVFNTGMSGYQEVITDPSYTGQLITFTYPELGNTGVNQEDLEADTPAVKAVLCRCLAPQPSNWRSSGTLEQWLEQHGVVGLKGIDTRAVVRQLRDGGAINGAVSTDGTSPAELLKQVLAAPSMAGQNLAERVSTTRAYRWSSPTAAAFDRRLQDQPVDRYRVVAIDFGIKRAILERLSAHGCDVEVLPAGSDADAVLALKPDGVFLSNGPGDPSAVGSGIALAKQLLSDPALPMFGICLGHQILGLALGGSTFKLGYGHRGLNHPCGGSGLVEITSQNHGFALDANSLDPQRVAVTHHNLNDRTVAGLELRDQPVFGVQYHPEASPGPHDADHHFARFINLMASRRNADKIERLS
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: NAT1_YEAST
Sequence: MSRKRSTKPKPAAKIALKKENDQFLEALKLYEGKQYKKSLKLLDAILKKDGSHVDSLALKGLDLYSVGEKDDAASYVANAIRKIEGASASPICCHVLGIYMRNTKEYKESIKWFTAALNNGSTNKQIYRDLATLQSQIGDFKNALVSRKKYWEAFLGYRANWTSLAVAQDVNGERQQAINTLSQFEKLAEGKISDSEKYEHSECLMYKNDIMYKAASDNQDKLQNVLKHLNDIEPCVFDKFGLLERKATIYMKLGQLKDASIVYRTLIKRNPDNFKYYKLLEVSLGIQGDNKLKKALYGKLEQFYPRCEPPKFIPLTFLQDKEELSKKLREYVLPQLERGVPATFSNVKPLYQRRKSKVSPLLEKIVLDYLSGLDPTQDPIPFIWTNYYLSQHFLFLKDFPKAQEYIDAALDHTPTLVEFYILKARILKHLGLMDTAAGILEEGRQLDLQDRFINCKTVKYFLRANNIDKAVEVASLFTKNDDSVNGIKDLHLVEASWFIVEQAEAYYRLYLDRKKKLDDLASLKKEVESDKSEQIANDIKENQWLVRKYKGLALKRFNAIPKFYKQFEDDQLDFHSYCMRKGTPRAYLEMLEWGKALYTKPMYVRAMKEASKLYFQMHDDRLKRKSDSLDENSDEIQNNGQNSSSQKKKAKKEAAAMNKRKETEAKSVAAYPSDQDNDVFGEKLIETSTPMEDFATEFYNNYSMQVREDERDYILDFEFNYRIGKLALCFASLNKFAKRFGTTSGLFGSMAIVLLHATRNDTPFDPILKKVVTKSLEKEYSENFPLNEISNNSFDWLNFYQEKFGKNDINGLLFLYRYRDDVPIGSSNLKEMIISSLSPLEPHSQNEILQYYL
What is the function of this protein?
Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala.  N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.  NAT1 anchors ARD1 and NAT5 to the ribosome and may present the N termini of nascent polypeptides for acetylation.
What are the official names of this protein?
N-terminal acetyltransferase A complex subunit NAT1, NatA complex subunit NAT1, Amino-terminal, alpha-amino, acetyltransferase 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTL_MOUSE
Sequence: MYTFVVRDENSSVYAEVSRLLLATGYWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLAQLVNYYRGADKLCRKASLVKLVKTSPELSESCSWFPESYVIYPTNLKTPVAPAQNGIQLPVSNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDSQGQVHVIQKYLERPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEEFNQYLTSALNITLESSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLLGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDTEQVPQQPAAFVKL
What is the function of this protein?
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
What are the official names of this protein?
Tubulin--tyrosine ligase, TTL.
What is the protein family that this protein belongs to?
Belongs to the tubulin--tyrosine ligase family.