PharMolix/UniProtQA huggingface dataset:
Protein: C3H31_ARATH
Sequence: MAVSSPTSSSSSSESLPLPSSNFASLPIMAMKRRIIDKILENRVTLIVGEPGCGKSSQVPQFLLEANMAPILCTQPRRFAVVAVAKMVAKSRNSDLGGEIGYHIGHSKILTEGSKILFKTAGVLLDEMLDKGLNALKYKVIILDEVHERSVESDLVLVCVKQFLMKNNDLRVVLMSATADITRYRDYFKELGRGERVEVVAIPSPDQRTIFQRRVLYLEQVAGLLGVSSDLSAYCPGPSPSSADTEIKPELQNLIHDLILYIHEKEPDIEKSILVFLPTYYSLEQQYHQLEPFFASFEVHILHRSIDTEQALAAMKICRSRRKVILATNIAESSVTIPKVAYVIDSCRSLQVFWDPSRKRDAVQLVWVSRSQAEQRRGRTGRTCDGEVYRLVPSAFFNKLEEHEPPSILKLSLRQQVLHICCTESRAINDANALLAKAMDPPDPDVVDDALRMLLSIQALRKSPRGRYEPTFYGRLLASFPLSFDASILVVKFGEMGMLRQGILLGVLMDTLPLPIHHPFGDDSLFLEYVDHYFGGSKTISGGRREMVLMANFCAFQFWQRVFKDKHRLENLKQLLSKEKDKDLKLMFPEIEKEWCDFHNIAQSSFYHVSELYEDTLSSFHRFRPQFISSSDSQPTYYNPYEFDHTCYIECQPSEDKYLHSEDVDNNQPPPEVRKCVSVPFVPPNAFQANAIAENMASIIKEIRTQCTPSESDNGHGALEPEDYVEYGEAPVCVYFLNGYCNRGGQCTFTHTLQSTRPACKFFASSQGCRNGESCLFSHAMRRRTTSYLPPPQCLPEEDGSSTSPLLDLFPTSSEGCILVFDDSDMHFTSSIANRYPSWRILSTSSSSETLFCDSSLADTRIFWGLNHPYQTIISKAGRENPIPWNEVKCVLWFLNPDSYADTPEKQKTILQNFFEHMAIRLLGDKLYKIRVVLTMNNVRFSLLQVEKLARESFFFLGESFPHDSESFGAFQDTLTIQKPMLVSRPISYVFNLHPPSDIQFGNYTSLLRKSLHNK
What are the official names of this protein?
DExH-box ATP-dependent RNA helicase DExH8, Zinc finger CCCH domain-containing protein 31, AtC3H31.
What is the protein family that this protein belongs to?
Belongs to the DExH box helicase family.
Protein: PPE25_MYCTO
Sequence: MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQYAEMWAQDAVAMYGYAAASASASRLIPFAAPPKTTNSAGVVAQVAAVAAMPGLLQRLSSAASVSWSNPNDWWLVRLLGSITPTERTTIVRLLGQSYFATGMAQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGASRAVSVSLARANKIGALSVPPSWVKTTALTESPVAHAVSANPTVGSSHGPHGLLRGLPLGSRITRRSGAFAHRYGFRHSVVARPPSAG
What are the official names of this protein?
Uncharacterized PPE family protein PPE25.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: RL4_THESM
Sequence: MKVKVFSLNGEPIEEITLPKVFQTPFRPDLIKRAVIASWTHRIQPQGRDPLAGKRRVTENIGKGRGMARVERIKTSPRFAAFVPFARGGRRAHPPKVEKVIWEGINKKEKKLALMSAIAATANYDLVRARGHVIDNIPQVPLVVENELEKVYRTAQTREIFKKLGIWEDIERAKRNTKVRAGKGKMRGRRYKKAKGPLIVVAKNEGIIQGARNHPGVDVVVVDNLGVELLAPGAHPGRLTIWTKGAIERLREFYG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ACCD_SHIBS
Sequence: MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARNRLHSLLDEGSLVEMGSELEPKDVLKFRDSKKYKDRLASAQKETGEKDALVVMKGTLYGMPVVAAAFEFAFMGGSMGSVVGARFVRAVEQALEDNCPLICFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPLGFQRSEFLIEKGAIDMIVRRPEMRLKLASILAKLMNLPAPNPEAPREGVVVPPVPDQEPEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSH1_SCHPO
Sequence: MGLLVLGTPLDWPESKKYCDYVRENGIMQFLHMYDTYISKKQDVLLWGDEIECIVVSMDDKSKKARVSLRQEDILNALGKYEETFRHVDFGPVYAALRNETCPKKIDAILSEVAKNPADYVERIGGNSNKDTIEITSSTKPHAQNAVPTFHPEYGRYMLESTPGAPYGSTLKDFTFVEYNMRLRRKIIENHLLPNELPLTITNFFRLGTPGFTDPEVEANGAISRSFFLPDDVINTHVRFPTLTANIRQRRGRKVAMNVPIFFDKNTIKPFHDPTVPWDRNLFPEDANARDGAALDNHIYMDSMGFGMGCCCLQITFQAKSCDEARLLYDQLTPITPLMLALSAGTPAFRGYLADQDCRWNVIAGAVDDRTEEEMKTVPKSRYDSVDLYISNDKRNLPEYNDVPVVINQDCYDKLIKDCIDERLAKHMAHIFSRDPLVIFSDSILQDNSVSNAHFENLNSTNWQSMRFKPPPPGSDIGWRVEFRSMEIQITDFENAAYSIFVVMLSRAILSFNLNLYMPISLVDENMKAAHARDAIHRKKFWFRCNPFPDASTDDESGQFRQLTIDELFNGEHRENGFPGLITIVRSYLYSCNPDAKTICLIERYIRLISQRANGQCLTAASWIRNFITTHPSYKQDSVVNDEINYDLIRRIAKIVDGDYDDTLLGKCS
What is the function of this protein?
Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 3 family.
Protein: KDUI_ECOBW
Sequence: MDVRQSIHSAHAKTLDTQGLRNEFLVEKVFVADEYTMVYSHIDRIIVGGIMPITKTVSVGGEVGKQLGVSYFLERRELGVINIGGAGTITVDGQCYEIGHRDALYVGKGAKEVVFASIDTGTPAKFYYNCAPAHTTYPTKKVTPDEVSPVTLGDNLTSNRRTINKYFVPDVLETCQLSMGLTELAPGNLWNTMPCHTHERRMEVYFYFNMDDDACVFHMMGQPQETRHIVMHNEQAVISPSWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVKDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: MDH_BURMS
Sequence: MAKPAKRVAVTGAAGQIAYSLLFRIANGDLLGKDQPVILQLLDLPQAQAAVKGVVMELDDCAFPLLAGVVITDDPKVAFKDADVALLVGARPRSKGMERKDLLSANAEIFTVQGAALNEVASRDVKVLVVGNPANTNAYIAMKSAPDLPKKNFTAMLRLDHNRALSQLAAKSGKPVASIEKLAVWGNHSPTMYPDFRFATAEGESLLKLINDDVWNRDTFIPTVGKRGAAIIEARGLSSAASAANAAIDHVRDWVLGTNGKWVTMGIPSDGSYGIPEDIIYGVPVICENGEYKRVEGLEIDAFSREKMDGTLAELLEERDGVAHLLK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: LEKR1_HUMAN
Sequence: MDHHIPMHALPEEIQKMLPEEKVCKYCGVSYLILHEFKAMEEKVKAMEKEMKFYQGSVDREKRLQEKLHSLSQELEQYKIDNKSKTERIYDVGMQLKSQQNEFQKVKKQLSHLQDELKIKYRQSYIFRLCFC
What are the official names of this protein?
Protein LEKR1.
Protein: RL24_STAAW
Sequence: MHIKKGDNVKVIAGKDKGKEGKVIATLPKKDRVVVEGVNIMKKHQKPTQLNPEGGILETEAAIHVSNVQLLDPKTNEPTRVGYKFVDGKKVRIAKKSGEEIKSNN
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: ZIPA_SALA4
Sequence: MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDDDVEEDEGVGEVRVHRVNHAPGQSQEHDAPRQSPQHQYQPPYASAQPRPAAPPQPQAPMQQPVQQPVQPASQPQQVQPSAPPVQPPQQQSAPPSQAPQPVAQPAPPPSAQTFQPAEPVVEAEPVVEEAPVVEKPQRKEAVIIMNVAAHHGSELNGEVLLNSIQQSGFKFGDMNIFHRHLSPDGSGPALFSLANMVNPGTFDPEMTDFTTPGVTIFMQVPSYGDALQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDRIREVMDANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: LCPS_NEUCR
Sequence: MYDYAFVHLKFTVPAAVLLTAIAYPILNRIHLIQTGFLVVVAFTAALPWDAYLIKHKVWSYPPEAIVGPRLLGIPFEELFFFVIQTYITALVYILFNKPVLHALHLNNQQNPPAWMRVVKVTGQVVLVALSVWGWNAAQVHQETSYLGLILVWACPFLLAIWTLAGRFILSLPWYATVLPMFLPTFYLWAVDEFALHRGTWSIGSGTKLDFCLFGKLDIEEATFFLVTNMLIVGGMAAFDQYLAVIYAFPTLFPKVNRYPTTHMLLQSRLINTSRYDLERIEGLREAVERLRLKSRSFYLANSLFSGRLRIDLILLYSFCRLADDLVDDAKSRREVLSWTAKLNHFLDLHYKDADATEDPKKKAERIDAYIKTAFPPCAYQALHLLPTHILPPKPLYDLIKGFEMDSQFTFHGTSDSTDLQYPIADDKDLENYAIYVAGTVGELCIALIIYHCLPDMSDTQKRELETAACRMGIALQYVNIARDIVVDARIGRVYLPTTWLKKEGLTHKMVLENPEGPEVIERMRRRLLENAFELYGGARPEMQRIPSEARGPMIGAVENYMAIGRVLRERKEGTVFVRMEGRATVPKRRRLSTLLRALYEQ
What is the function of this protein?
Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and from lycopene to beta-carotene via the intermediate gamma-carotene and from 3,4-didehydrolycopene to torulene (lycopene cyclase).  Torulene is further processed to the acidic carotenoid neurosporaxanthin.  The cyclase preferentially catalyzes single cyclizations at only one end of the substrate to produce monocyclic carotenoids (PubMed:11862485, PubMed:16928467).  Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities.  Phytoene synthase activity performed by the bifunctional enzyme al-2 first produces phytoene from geranyl-geranyl pyrophosphate (GGPP).  The phytoene dehydrogenase al-1 then introduces 5 desaturations to lead to 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene.  Al-2 cyclase activity then converts 3,4-didehydrolycopene into torulene.  Al-2 can also convet lycopene into gamma-carotene which in turn is converted to beta-carotene by an additional al-2 cyclization reaction.  Torulene is the substrate of the dioxidase cao-2 that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase ylo-1 mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
What are the official names of this protein?
Bifunctional lycopene cyclase/phytoene synthase, Protein albino-2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phytoene/squalene synthase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SSN3_PICST
Sequence: MASNSILTLGPFKHRKDLTRESVLSTYQIIGYIAAGTYGKVYKAKLKNTASAEQLFAIKKFKSDNHSSNRSHHNHDINGNEIVHYTGISQSAIREMSLCRELNNKNITKLVDIILENKSIYMIFEFCEHDLLQIIHYHSHPEVKPIPQATVKSLIWQILNGVTFLHQNWIFHRDLKPANIMVSSSGVVKIGDLGLARKFNNPLQSLYTGDKVVVTIWYRAPELLLGARHYTPAIDLWAVGCILAELLSLRPIFKGEEAKIDINNKKSVPFQKNQFQKIVEVLGTPSMKNWPALNKYPEFISFQQQLTTNYPPNLVNWYKMIGSSNKQCLELLKGLLEYDPLVRLTADNALVHPYFLELPKVQENAFEGLNLKYPKRRIYTDDNDIISNQAINQNFKRHGGAYDDQHNNSNNNTNNSLNANNANNVPRKRAR
What is the function of this protein?
Component of the srb8-11 complex.  The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription.  The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase SSN3, Cyclin-dependent kinase 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVB_RHOE4
Sequence: MNFDPIDDFDDESQVSAELVAGDGDVEASLRPKSLDDFIGQPRVREQLQLVLTGAKLRGSTPDHILMSGPPGLGKTSMAMIIAGELGSSLRLTSGPALERAGDLAAMLSNLVEGDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPEELQQILMRSAGILGVNLEVDAGAEIARRSRGTPRIANRLLRRVRDFAEVRADGIVTMDVAQAALAVYDVDQLGLDRLDRSVLSALVRSFGGGPVGVSTLAVAVGEEPSTVEEVCEPFLVRAGMIARTPRGRVATAAAWTQLGMTPPPDAAAGGIEVRVNEPQATLFDPNGE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: DCD_SALNS
Sequence: MRLCDRDIEAWLDEGRLSITPRPPVERINGATVDVRLGNKFRTFRGHTAAFIDLSGPKDEVSAALDRVMSDEIVLPDGEAFYLHPGELALAVTFESVTLPPDLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNRRQDAKYRDQQGAVASRIDKD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: H2AZ_MOUSE
Sequence: MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV
What is the function of this protein?
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  May be involved in the formation of constitutive heterochromatin.  May be required for chromosome segregation during cell division.  Essential for early development.
What are the official names of this protein?
Histone H2A.Z, H2A/z.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
Protein: BRO1_KLULA
Sequence: MKTVLLPLKIKDTESISWTKGLITYLKRSYGSSQWSVFYDGDKTAEIDSCRTTANSDLAPESLLDQNYKYAAILEQIYLRLGAHSGSLQMDFTWYEAEYHSRLSEKKFKQHTVVFEKSSVMYNIGVLLSQIAKKKMSDNYKSAIPYLSKAMACFDYMSNNFLNSPSIDCAAENTSFLSTLLHAEAQEMFLMTLINGPDASKRASLISKLAHTALNLYEKCQEFYEDSSTATFGTTPYGEDKWKDIITLKVHLYRAISTYNHLRVLEEAKKIGEAIAYGKLAVHEIKEAGFYKVYVKDEIDLTGLKAVIEEKLKSLIKDNDFIYNDLIPADVSIESIKTMDAVKPVTWEEQLKVYLEQVVDLCNGAFKGIVPMEVYENESIYSEEKASLLRKEVEETDTADWEYQSFIEFTDLPKLIKDLESRYVHGGNGSSDDPQYEIMKQKITTWSKVVQDSNFKDVRAQMQNILDKRNEILTILSSVSPDQRENALKIKNSLVQASQSDDKIFASINPCLEEVNLLANHQLLWSIMSKFQIRNDEPSLLDLDDSKNQQILDRLHNIKHNQEILRLLKEERTRNLKDFKESLNNDDITQKLILLTGKPKKEMRVIFEEELTKFKPLSTRIEATIFKQNNLINDIKIKLDEVFKLIGVQDKTPEQENTVKERQTFFDKVEKAFNQFVIFSTDLPKGLNFYDTLLKMTRELSHASTPGQSVNLIDSNTLPPNLPQKSTQSTTLTKSFANLNLCNDVNDSVTQSPANLANTNNTGVNPGPPQLPPKPLSTGISGLVSDQKLQNGPTSFYNNPSVFDENLYSKFSK
What is the function of this protein?
Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.
What are the official names of this protein?
Vacuolar protein-sorting protein BRO1, BRO domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the BRO1 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome.
Protein: HIS5_BACAC
Sequence: MIAIIDYGMGNIRSVEQALKYIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDILEEKDLVRMLQEIGRSRKPLLGICLGMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWNELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISDYGVKVPGFVAKGNIYGAQFHPEKSGDIGMQMLKNFKGVVETWKSSQLSI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_BURTA
Sequence: MQYSFTEKKRIRKSFAKRSIVHQVPFLLATQLESFSTFLQADVLPAQRKSEGLQAAFTSVFPIVSHNGFARLEFVSYALSSPAFNIKECQQRGLTYCSALRAKVRLVLLDKESPSKPVVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDVLYFRVDRRRKMPVTILLKAIGLTPEQILANFFVFDNFTLMDEGAQMEFVPERLRGEVARFDITDREGKVIVQKDKRINAKHIRDLEAAKTKYISVPEDYLLGRVLAKNVVDGDTGEVIANANDEITEGVLDKLREAKIKEIQTLYTNDLDQGPYISSTLRVDETVDKTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEDAYDLSKVGRMKFNRRVGRDEITGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAISNDGSLVDELVSSREAGETMMVTPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTVAVDSGTTVQALRGGVVDYVDAGRIVIRVNDDEAVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVARGDVLADGASTDLGELALGQNMLIAFMPWNGYNFEDSILISERVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREGIQRDKRAQQIIDDELKRYRLDLNDQLRIVEGDAFQRLARMLVGKVANGGPKKLAKGTKIDQAYLEDLDHYHWFDIRLADDEAAAQLEAIKNSIEEKRHQFDLAFEEKRKKLTQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPVEDMPYMADGRPADVVLNPLGVPSRMNVGQVLEVHLGWAAKGLGWRIGEMLARQTKIEELRVFLTKIYNESGRAEDLESFSDDEILELAKNLREGVPFATPVFDGATEEEMSKMLDLAFPDDIAEQLDMNPSKNQVRLYDGRTGEPFERRVTVGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDIDLDRN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: ACUC_STAAS
Sequence: MQQHSSKTAYVYSDKLLQYRFHDQHPFNQMRLKLTTELLLNANLLSPEQIVQPRIATDDELMLIHKYDYVEAIKHASHGIISEDEAKKYGLNDEENSQFKHMHRHSATIVGGALTLADLIMSGKVLNGCHLGGGLHHAQPGRASGFCIYNDIAITAQYLAKEYNQRVLIIDTDAHHGDGTQWSFYADNHVTTYSIHETGKFLFPGSGHYTERGEDIGYGHTVNVPLEPYTEDASFLECFKLTVEPVVKSFKPDIILSVNGVDIHYRDPLTHLNCTLHSLYEIPYFVKYLADSYTNGKVIMFGGGGYNIWRVVPRAWSHVFLSLIDQPIQSGYLPLEWINKWKHYSSELLPKRWEDRLNDYTYVPRTKEISEKNKKLALHIASWYESTRQ
What is the function of this protein?
Role in growth on acetoin or butanediol.  Involved in the breakdown of these compounds used as a carbon source (By similarity).
What are the official names of this protein?
Acetoin utilization protein AcuC.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family.
Protein: ATP6_PSEE4
Sequence: MAAETASGYIQHHLQNLTYGQLPDGSWGFAHSAAEAKAMGFWAFHVDTLGWSLAMGLLFIWLFRMAAKRATTGVPGGLQNFVEVLVQFVDSSVKDTFHGRNPLIAPLALTIFAWVFLMNSIDLVPVDWIPQIAMAISGDEHLFFRAVPTTDPNATLAMSLSVFALIIIYSIKVKGLGGFLGELTLHPFSSKNIVLQIILIPVNFLLEFVTLIAKPFSLALRLFGNMYAGELVFILIAVMFGAGLLWLSGIAVVLQWAWALIHIFIITLQAFIFMMLTIVYLSMAHEDNH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TERF1_HUMAN
Sequence: MAEDVSSAAPSPRGCADGRDADPTEEQMAETERNDEEQFECQELLECQVQVGAPEEEEEEEEDAGLVAEAEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRNSAEAIIHGLSSLTACQLRTIYICQFLTRIAAGKTLDAQFENDERITPLESALMIWGSIEKEHDKLHEEIQNLIKIQAIAVCMENGNFKEAEEVFERIFGDPNSHMPFKSKLLMIISQKDTFHSFFQHFSYNHMMEKIKSYVNYVLSEKSSTFLMKAAAKVVESKRTRTITSQDKPSGNDVEMETEANLDTRKSVSDKQSAVTESSEGTVSLLRSHKNLFLSKLQHGTQQQDLNKKERRVGTPQSTKKKKESRRATESRIPVSKSQPVTPEKHRARKRQAWLWEEDKNLRSGVRKYGEGNWSKILLHYKFNNRTSVMLKDRWRTMKKLKLISSDSED
What is the function of this protein?
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length.  Involved in the regulation of the mitotic spindle.  Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection.  Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
What are the official names of this protein?
Telomeric repeat-binding factor 1, NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
Protein: UBP72_SCHPO
Sequence: MVTGETLVDSQKSLINNDTLLNEKLKEDFEENVSIDVKIHEELRRALPDYEESGFQRFTWHIKSWHELDRRAVSPQFAVGSRQFKITYFPQGTLQSAGFTSIFLEYIPSEEEKLSNKYGCCCQFAFVISNPRKPSLSVANSAHCRFSPEIVDWGFTQFAELKKLLCRQAPDVPPIVEDGALLLTAYVRILKDPTGVLWHSFNDYDSKIATGYVGLKNQGATCYMNSLLQSLYIIHAFRRIVYQIPTDSPQGKDSIAYALQRCFYNLQFMNEPVSTTELTKSFGWDSLDSFMQHDVQEFNRVLQDNLERSMRDTKVENALTNLFVGKMKSYIACVNVNFESARSEDYWDIQLNVKGMKNLEDSFRSYIQVETLEGDNCYFADTYGFQEAKKGVIFESFPPILHLQLKRFEYDFERDMMIKINDRYEFPLEFDAKAFLSPEADQSQNCEYVLYGVLVHSGDLHNGHYYALLKTEKDGPWYKYDDTRVTRATLREVLEENYGGDYIMHPPFRSPVKLKRFMSAYMLLYLRKDKLDELMNPVSADEIPEHLKEALNPSIQLAELRRKERLESHLYTKVQLITPEFYSEHHEFDIADFGNAYKEETIPQFRIKKEAKFSEFIPIVAEKLGYPQECMRFWYVVKRHNCTVRVESPVNELNSTMEEVKNVWNSQGEILRLYLEITPENELSSSLTHQNTGEWNAFIFVKYFDRKSQEISGCGTLHVNKSDEIRSICPLLCERANLPKNTPLNIYEEIKPGMVDFLRLEKTFTQSELSTGDIICFEPCRPSALEDDIVNSGFDSALKLYDFLSNKVLVLFRPRFIDQDSIIEFEMLLDRRIKYDDLCIELGQKLGIGADHIRLTTCNPLTYSAGMVVPNDSNITLYEILYSSEEEMPSNVIFYETMDVSLSDLDRKRLVRLRWLVDGLANIELVEAYINKSGDINDLFGAVCERFPDSDLRKKKVRVYEVFESRYHRDLSLRTLIRTINPAATLVGEVVPLDQLQLYPEEKIVQVHHFHKDIARIHGIPFSFVIKPQEKFIDTKLRLAARTQYPESIFSVIKFCVVDFDNNRVVYLNDEDITYDVVEKLNGTLALDRAKKDSKKPNILDRAIQMKN
What is the function of this protein?
Hydrolase that deubiquitinates target proteins (By similarity).  Cleaves the UBL propeptide in sde2 (PubMed:28947618).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: NIT2_MOUSE
Sequence: MSTFRLALIQLQVSSIKSDNLTRACSLVREAAKQGANIVSLPECFNSPYGTTYFPDYAEKIPGESTQKLSEVAKESSIYLIGGSIPEEDAGKLYNTCSVFGPDGSLLVKHRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCKVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRARAVDNQVYVATASPARDDKASYVAWGHSTVVDPWGQVLTKAGTEETILYSDIDLKKLAEIRQQIPILKQKRADLYTVESKKP
What is the function of this protein?
Has omega-amidase activity (PubMed:19596042, PubMed:28373563).  The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19596042).  Can also hydrolyze gamma-monomethyl-alpha-ketoglutarate in vitro (PubMed:19596042).
What are the official names of this protein?
Omega-amidase NIT2, Nitrilase homolog 2.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
What are the subcellular locations of this protein?
Cytoplasm.