PharMolix/UniProtQA huggingface dataset:
Protein: RPOH_CITFR
Sequence: MTKEMQNLALAPVGNLESYIRAANAWPMLSADEERALAEKLHYQGDLEAAKTLILSHLRFVVHVARNYAGYGLRQADLIQEGNIGLMKAVRRFNPEVGVRLVSFAVHWIKAEIHEYVLRNWRIVKVATTKAQRKLFFNLRKTKQRLGWFNQDEVEMVARELGVSSKDVREMESRMAAQDMTFDMSSDDESDSQPMAPVLYLQDKSSNFADGIEEDNWEDQAANKLTHAMEGLDERSQDIIRARWLDEDNKSTLQELADRYGVSAERVRQLEKNAMKKLRAAIEA
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is involved in regulation of expression of heat shock genes.
What are the official names of this protein?
RNA polymerase sigma factor RpoH, RNA polymerase sigma-32 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDP_STAEQ
Sequence: MRMIDIIEKKRDGKSLTKEEIEFFVNGYTHGEVPDYQASSLAMAIFFQDMNDEERAALTMSMVNSGEKIDLSDINGIKVDKHSTGGVGDTTTLVLAPLVAAVGVPVAKMSGRGLGHTGGTIDKLESVKGFNVEISEKDFIKLVNDNQVAVIGQSGNLTPADKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLDDAEALAHAMVRIGNNVGRNTMAIISDMSQPLGNAIGNALELKEAIATLKGNGPKDLTELVLTLGSQMVVLAEQATSLDEARQMLIDAIKTGKALNKFKTFLSNQGGDDSIVDSPEKLPSAKYQVEFKAKKDGYITEIIANEIGVASMMLGAGRQTKEDVIDLGVGIVLNKKVGEHVEKGENILTIHTNTKEIDDILYKLDNSITIESKGEAPTLIHKIITE
What is the function of this protein?
Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
What are the official names of this protein?
Pyrimidine-nucleoside phosphorylase, PYNP, Py-NPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: PHNX_BACC7
Sequence: MKIEAVIFDWAGTTVDYGCFAPLEVFIKIFRKRGVKITDEEARKPMGLLKIDHVRALTEMPRIANEWERVFGHLPTEADIHEMYEEFEEILFTILPHYATPIDGVKEVVASLRKRGLKIGSTTGYTREMMDIVAKEAEIQGYKPDVLVTPDDVSAGRPYPWMCYKNAMELGVYPMNHMIKVGDTVSDMKEGRNAGMWTVGVILGSSELGLSEWAAETMDPVELREKMEVVRKRFVENGAHFTIETMQGLENVIEQIEKQEFIIS
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
Phosphonoacetaldehyde hydrolase, Phosphonatase, Phosphonoacetaldehyde phosphonohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PhnX family.
Protein: AT1_TOXGM
Sequence: MAGLLSSCCGRVYALLPDSAHPSAQQKTPFGVNRYVLLVIYMIYALLTSSVYFGWRSMSAMLFKSGQFSWVCTGESADTSPEEGETDYLCALQDTKVQSLFTIAMACHFTCSAVAGYLLDTVGPKAVALLGQTFNALAWILLAFSGPNFRSVYPAFVFMGAGADVSVYPTLLIVNLFPGSTALIMATLGACISLSFFVPLVLRTMWESTGISFEAVCIGYAVAGPILCAVVAFFFIPFKAFKGVDNFSACVEAEKLANSPTAQSSPKAVDSPPCDEGASSRGRLAVSHNTERTAPDDEQEKDNTERISLSDLACDPRFKKQKVSFSSQAFTFLYFGICLYFTVCGWVMAYYQEAAGRFLCNDAEYTLEILTPLSTIPCLLFGVVINRIGIMPVILMLNTIGLLTYVCVVAAESVVAQYFSVIFFFMYISIFTTQMYVFVESTFDSAHFGKLIGVASLIGGLLSLISNVLYGDVTVGMLNGDTRPVVIALLAVIILMYPILLAMRTKRNRKKQMEQEDIRSRVLELKAAHAADAA
What is the function of this protein?
Selective L-arginine transporter that is essential for parasite survival and virulence (PubMed:28205520, PubMed:30742695).  Does not require other inorganic ions such as sodium, chloride, potassium or calcium (PubMed:28205520).
What are the official names of this protein?
Arginine transporter 1, Amino acid transporter 1, Apicomplexan amino acid transporter 1, TgApiAT1, Major facilitator superfamily domain-containing protein, Novel putative transporter 1, TgNPT1.
What is the protein family that this protein belongs to?
Belongs to the SLC43A transporter (TC 2.A.1.44) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NGL3_YEAST
Sequence: MDSQVEGKISPSQKESSSTSGLVSPSEDGPAHQKIHRDQLSVDQIKKIREERAQKRQVRRNSLISQGKDPDFPTPDLQFIERPFLPINHDNSKGLTPATIQVTQDSLDVKIMTYNTLAQTLIRRDFFPESGPALKWHKRSKVLVHELKKYRPDVVSLQEVDYNELNFWQENFHKLGFDVIFKRHEGKTHGLLVAWNNKKFQLDNDWMLDYDNILAGNVISARTRTKNIALIISLYFKGITDSSSRGIIVANTHLFWHPFGVFERLRQSYLVLQKIQEIKACSKYNGWHSLLMGDFNTEPEEPPYLAITKRPLILKGPIRAMVECSLAYRYSKKRNGEESDQDDEECDEKSRGEGHSDQPQNPKPESFTATKEEKALVNQLVALHNSLHVKGVSLYGIGYGKVHPENANGSHGEPGLSNWANTWCGLLDYIFYIEGDHNQDTRQKEPLNAFEGNNNVKIIGYLRMPCAQEMPKHSQPFEGEYASDHISLMCQIRLFFGGEKVHSLK
What are the official names of this protein?
Probable RNA exonuclease NGL3.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
Protein: RRF_MALP2
Sequence: MEWKIYKEEFDKKAEVKLEWLDSEFNKIKSGRPNPKILDHVMVEAYGDKSKLFEIANMQVVEGKQIVVKPYDKTLLHDINSAIQKENLGLSVQVDADSLRIIFPSPTEETRKASVKKVKEFSEQVKVEIRNIRKDVHHKIKDDKELREDELKWYEEDLDKLTREWNAKVDKAFAEKEKELMTI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFB_RHOCB
Sequence: MIAAAASMSALGLGLGYLLGAAARKFHVETPPIVEEIAKILPGTNCGACGFPGCNGLAEAMAEGNAPVTACTPGGRDVALALAEIVTVEAGADAGPIAEIEPMVAFVFEDHCTGCQKCFKRCPTDAIVGGAKQIHTVVMDACIGCDACIEVCPTEAIVSRVKPKTLKTWYWDKPQPGLVAASAETAA
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity).  Required for nitrogen fixation.  Stabilizes RnfC (PubMed:9154934).
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Nitrogen fixation protein RnfB, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cellular chromatophore membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HXB1_ATEGE
Sequence: MDYNRMNSFLEYPLCNRGPSAYSAHSAHSAPTSFPPSSTQAVDSYASEGRYGGGLSSPAFQQNSGYPAQQPPSALGVPFPSSAPSGYAPAACSPSYGPSQYYPLGQSEGDGGYFHPTSYGAQLGGLSDGYGAGGAGPGPYPPQHPPYGNEQTASFAPAYADLLSEDKEAPCPSEPNTPTARTFDWMKVKRNPPKTGKVSEPGLGSPSGLRTNFTTRQLTELEKEFHFNKYLSRARRVEIAATLELNETQVKIWFQNRRMKQKKREREGGRVPPAPPGCPKEAAGDASDQSTCTSPEASPSSVTS
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Acts on the anterior body structures (By similarity).
What are the official names of this protein?
Homeobox protein Hox-B1.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Labial subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPEL_STRTD
Sequence: MTLDLIKIRRDLHQIPEIGLEEFKTQAYLLERIAEMTEGKDFVEQRTWRTGILVFLHGSAPEKTIGWRTDIDGLPIVEETGLDFKSIHEGRMHACGHDIHMTTALGLLDQMLQVQPKNNMLFLFQPAEENEAGGMLMYEDGAFGDWLPDEFYGLHVRPDFKVGDIATNTNTLFAGTCEVLVTFKGKGGHAAFPHEANDALVAASYFITQVQTIVSRNVDPIQGGVVTFGSFHAGTTNNVIAETAEVYGTIRTLTQEMSLLIQKRVRQIAEGVAASFGMEVDIMLKQGGYLPVENNPALAKELMAFFDASPMVNLIDCLPAMTGEDFGYLLSKVPGVMFWLGIDTPYALHHPKMSPNEEALAFAVSEIGKFLKYKAED
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: RLMN_HELPY
Sequence: MKASIYDFTLKELSQLLKPSFRAKQLYLWLYAKYKTSFKDMQNNFSKDFIAYLEREFALRTIEITHVRESVDGSKKYLFKSLRDNHTFEAVLLKMKDKKIDAETNAILEREKYTVCVSCQIGCQVGCSFCFTQKGGFVRNLKASEIIQQALLIKEDNNLPLEKALNIVFMGMGEPLNNLDEVCKAIEIFNTGMQISPKRITISTSGVADKIPILAGKNLGVQLAISLHAVDDKTRSSLMPLNKKYNIECVLNEVRKWPLEQRKRVMFEYLLIKDLNDSLDCAKKLLKLLNGIKSKVNLILFNPHEGSKFERPSLENARMFADFLNSKGLLCTIRESKALDIEAACGQLREKKLSQQI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PB1F2_I83A8
Sequence: MEQEQDTPWTQSTEHINIQKKGSGQQTQKLGRPNSTRLMDHYLRIMSQVDMHKQTVSWRLWLSLRNPTQGSLRTRALKQWKSFNKQGWTN
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: AZOR2_LISMF
Sequence: MSKVLFIKASPLPNEVSRSSQVAETFMAEYKAKNPSDTVEELVLYNTEVPLLDLELMTAGRELQAGKAFTDLAPDVQKKLNAYNALTEQFLAADKYVFVFPLWNLGIPPLLKAYIDTFVIAGKSFRYTEHGPEALLKDKKAILIHGSGGIYSAGPTSSFTHGEPYLRTILQFIGINVVPSIFVEGIDHNPSKEAEIVAAAKAVAQESAAEF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 2, Azo-dye reductase 2, FMN-dependent NADH-azo compound oxidoreductase 2, FMN-dependent NADH-azoreductase 2.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: CSN9_DANRE
Sequence: MKPAVDEMFPEGAGPYVDLDEAGGSSGLLMDLAANEKAVHSDFFNDFEDLFDDDDIQ
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity.  May play a role in cell proliferation.
What are the official names of this protein?
COP9 signalosome complex subunit 9.
What is the protein family that this protein belongs to?
Belongs to the CSN9 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nucleoplasm.
Protein: APT_FRATF
Sequence: MNLDFIKSKIAAVPDFPKPGIMFRDITPLLADPQGLRKTAEAMAQELKNKGIQPTIIAGTESRGFIFGVALAEVLGLGFVPVRKPGKLPRATYSVKYDLEYGSDSLEIHQDAFKVTDEVLVVDDLLATGGTAKATVDLIEKTQAKVAGLIFVMELDSLGGREVLAGYNVSALIKF
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPD_BACTN
Sequence: MKQSVIIVAGGKGLRMGSDLPKQFLPVGGKPVLMHTLEAFRKYDAMLQIILVLPREQQDFWKQLCEEHHFSVEHLVADGGETRFHSVKNGLALVQAPGLVGVHDGVRPFVTLEVIRRCYELAEQHKAVIPVVDVVETLRHLTDAGSETVSRTEYKLVQTPQVFEVELLKQAYGQEFTPFFTDDASVVEAMGVPVHLAEGNRENIKITTPFDLKIGSALL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: MENE_STAAS
Sequence: MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRLTPNEMKNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAGTDITMNGLLDNTMDIQYDTSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQILTIIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATLIETALQYNLPIYNSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTSTGKLQRNKLYRG
What is the function of this protein?
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
What are the official names of this protein?
2-succinylbenzoate--CoA ligase, o-succinylbenzoyl-CoA synthetase, OSB-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
Protein: DFI1_CANAL
Sequence: MEKLSINNNNNNRRYQSRRFDGITIIRIVVLVFIVTVSTYFVNSYTCNQPHHNHSTRPSHYLPINGTHGLMNNDDSLHNKGAIGHYNTTVSLERRADENNSTTNGLFPSTSSSTFIFTPSSSSSSTFQQSRSSPQTTSTSSFVATTSSFQQETSQTSIPDTTTDFSFSSFSEAPTTSTTSSTSEFSSTPQETSNTVTSTSSTSTSSSSSPTSSPATTSASQHVTTFSSVDNGKTIVVTRTSVISSSPTASNSNNNKNNDNGGGLSHTNRIVVGVVVGVGGSILIGLLAVLFYLRKRNNRDYEGGWTFWRKNEKLGSDEFFNGELGVRDRNINQGSNF
What is the function of this protein?
Cell-surface associated glycoprotein that acts as a plasma membrane receptor-type protein which senses the presence of matrix.  Binds to calmodulin in response to environmental conditions and initiates a signaling cascade that activates CEK1, thus promoting invasive filamentation.  Involved in the maintenance of the cell wall.
What are the official names of this protein?
Cell-surface associated glycoprotein DFI1, Defective in filamentous invasion protein 1.
What is the protein family that this protein belongs to?
Belongs to the MID2 like cell wall stress sensor family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell septum. Secreted, cell wall. Note=A part becomes cross-linked to the cell wall and thus links the cell wall to the plasma membrane and cytoplasm.
Protein: DDRGK_DANRE
Sequence: MDVVLYIAAAAILLVLIVFSVKIRGRTQDADVEDHQNVTARVSARPQAAPERAAGMPRRRRGLHSRVNAQRAQRASDNEDSPVEADEDEEGRNASEERPQAAGKVGAKKQRKLEEKQARKAQREAEQEEREERKRLQELRDQERQKEEEKERQQEQKQEEELQRVKEEQERREEEEYQRLKESFIIEDQGEAEELTEHESQSLLQEFIQYVQKSKVVLLEDLASQFGLRTQDAIARLQDLIADGSLTGVIDDRGKFIFITPEELNAVAQFIKQRGRVSISELAQASNTLINLTPDIHSSA
What is the function of this protein?
Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) (By similarity).  In response to endoplasmic reticulum stress, promotes recruitment of the E3 ufm1-protein ligase ufl1 to the endoplasmic reticulum membrane, leading to ufmylation of target proteins and subsequent reticulophagy of endoplasmic reticulum sheets (By similarity).  Plays a role in cartilage development through sox9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186).
What are the official names of this protein?
DDRGK domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the DDRGK1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum membrane. Note=Localizes to the endoplasmic reticulum membrane in response to endoplasmic reticulum stress.
Protein: RSXA_ECOSE
Sequence: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLNLIYLRTLAFILVIAVVVQFTEMVVRKTSPVLYRLLGIFLPLITTNCAVLGVALLNINLGHNFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rsx electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTTC2_METAC
Sequence: MAGKEEIIAKAKDSITEFDEEMAQEAANEALVAGLDPVEIIEHGYTAGMQYVGDQFEQGTLFLPHVLAAAEAMKAGIEVLQPEMEKRKAKTTTLGTVIIGTIEGDIHSIGKDIVASMLNIAGFEVVDLGRDVAIKTFVEKAKELKPDIVATSALMTTTMVNQIQLEEQLKEAGIRGQVKTMVGGAPVTQGWADKIGADIYGESATDAVNKIKAAIKS
What is the function of this protein?
Acts probably as a methyl group carrier between MttB and either MtbA or MtaA.
What are the official names of this protein?
Trimethylamine corrinoid protein 2, TCP 2.
What is the protein family that this protein belongs to?
Belongs to the methylamine corrinoid protein family.
Protein: GLMS_BARHE
Sequence: MCGIIGILGKRCVTSSLVESLKRLEYRGYDSSGIATVHNGRLYRIRAEGKLVHLEEKLQKTPLKGNLGIGHTRWATHGVAVERNAHPHVTERLAIVHNGIIENFVELQKELIEDGYTFETETDTEVIAHLITRALKSGLSPQEAIRTSWKRLQGAFAIVVIFEGEDNLMIAARSGPPLAIGYGKDEFFVGSDAIALAPFVDSISYMEDGDWAVLTREDITIYDVDNQPVKRPLTPLFEGALLASKGNHRHFMHKEMFEQPEVISHNLAHYLDLGNYTVRSFQKLIDWKKINRILFASCGTAYYSTLVARYWFESFAALSVDNDVASEFRYREPPINSDVLSVFVSQSGETADTLASLRYCREYGVKTATIVNVEQSTMAREADFVLPTRAGPEIGVASTKAFTCQLATLAAMALDAAKQRGFLAEQAEHQFVQQLAEVPRILNEVLKLDNKIEQICRNLVNVKGVLYLGRGTSYPIALEGALKLKELSYIHAEGYAAGELKHGPIALVDEAIPVIVVAPYDRWFEKTCSNMQEVAARNGRIILITDKKGAEAVHLDILSTIVLPNIPEFIAPIIYALPIQLIAYHTAVLLGTDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EGLN3_MOUSE
Sequence: MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHYNGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAINFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGVLRIFPEGKSFVADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALAKD
What is the function of this protein?
Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as PKM, TELO2, ATF4 and HIF1A (PubMed:24809345).  Target proteins are preferentially recognized via a LXXLAP motif (By similarity).  Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (By similarity).  Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (By similarity).  Also hydroxylates HIF2A (By similarity).  Has a preference for the CODD site for both HIF1A and HIF2A (By similarity).  Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site (By similarity).  Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (By similarity).  Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (By similarity).  ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia (By similarity).  Also hydroxylates PKM in hypoxia, limiting glycolysis (By similarity).  Under normoxia, hydroxylates and regulates the stability of ADRB2.  Regulator of cardiomyocyte and neuronal apoptosis (By similarity).  In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex (By similarity).  In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity (By similarity).  Also essential for hypoxic regulation of neutrophilic inflammation (PubMed:21317538).  Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (By similarity).  Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (PubMed:24809345).
What are the official names of this protein?
Prolyl hydroxylase EGLN3, Egl nine homolog 3, Hypoxia-inducible factor prolyl hydroxylase 3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-3, Prolyl hydroxylase domain-containing protein 3, PHD3, SM-20.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Colocalizes with WDR83 in the cytoplasm.
Protein: GPMA_AZOC5
Sequence: MDRLLVLVRHGQSEWNLKNLFTGWRDPNLTDQGVSEARRAGALLAAEGLSFDVAYTSALTRAQRTCQLVLEEMGLTGLRTIADQALNERDYGDLSGLNKDDARAKFGEEQVHVWRRSYDISPPGGESLRDTVARVLPYFVQEILPSVLRGERTLVAAHGNSLRALVMVLERLSPEGIMKRELATGAPILYRLGADATVSEKRDILI
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: RR12_NICSY
Sequence: MPTIKQLIRNTRQPIRNVTKSPALRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSKYGVKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL37A_RAT
Sequence: MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L37a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
What are the subcellular locations of this protein?
Cytoplasm.