PharMolix/UniProtQA huggingface dataset:
Protein: DVRA_ASPFU
Sequence: MTSFLPVNNTSSPQTRPMEEVATAATPRPHTNVSATEENRSRTMNSGTEDATPLNLHKVQEDSASRTKPSLGHNGTSHGESDADRDGSDHDSDAAGNAPPSKKKKGQRFYCTDFPPCNLSFTRSEHLARHIRKHTGERPFQCHCSRRFSRLDNLRQHAQTVHVNEEIPGDSLAATGTRFQRQIRTDRVRPQGRARAGTGGSQGTHSRGHSRNLSTSSIASTTSTYSQPPELRRRPPPLIMANDGSARTRLGLDTMADIPTTPPGQVRGIPGPAVAVGSPYTPSHRLFAAGGNGSPHLASARPAAAHMSGFWDGKTAARRLSVPTSANPFASQQPNNYPPSLVGSATPTTAAYPPGGVFASPVSSTHSFSREENAYSAADADLRRRTWHPSTHFALPRPATSGLSHYQTPDTVDAPVNASGATEQPPRLPGIESFDKVVLHQRPLTPPVRRPSPMQIDSHRKPSPSYALGGGFNYSQPANRPAPPISGPGHRRGHVSWDMSLHTNLTGLHIRDKPLPRDASHWSQQTIAELQNVSSRPSSSYQQQVQESRGITGHSAYEKMQGWYGGHTSGSQATRTSPEDSSSSEGVHTPSTASLEYHPAIVHNSGYIESHPPSMACDTSHSACPPLSQFSDGYQPHVKPDPRPDFYHNASVRDSGMGRLEALVAVATSENKNTAKLYG
What is the function of this protein?
Transcription factor that seems to function as negative regulators of virulence by affecting the capacity to damage host cells and to stimulate a pro-inflammatory response.
What are the official names of this protein?
C2H2 finger domain transcription factor dvrA.
What are the subcellular locations of this protein?
Nucleus.
Protein: WTR1_ARATH
Sequence: MAGDMQGVRVVEKYSPVIVMVMSNVAMGSVNALVKKALDVGVNHMVIGAYRMAISALILVPFAYVLERKTRPQITFRLMVDHFVSGLLGASLMQFFFLLGLSYTSATVSCALVSMLPAITFALALIFRTENVKILKTKAGMLKVIGTLICISGALFLTFYKGPQISNSHSHSHGGASHNNNDQDKANNWLLGCLYLTIGTVLLSLWMLFQGTLSIKYPCKYSSTCLMSIFAAFQCALLSLYKSRDVNDWIIDDRFVITVIIYAGVVGQAMTTVATTWGIKKLGAVFASAFFPLTLISATLFDFLILHTPLYLGSVIGSLVTITGLYMFLWGKNKETESSTALSSGMDNEAQYTTPNKDNDSKSPV
What are the official names of this protein?
WAT1-related protein At1g01070.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RBSA_ECOL5
Sequence: MEALLQLKGIDKAFPGVKALSGAALNVYPGRVMALVGENGAGKSTMMKVLTGIYTRDAGTLLWLGKETTFTGPKSSQEAGIGIIHQELNLIPQLTIAENIFLGREFVNRFGKIDWKTMYAEADKLLAKLNLRFKSDKLVGDLSIGDQQMVEIAKVLSFESKVIIMDEPTDALTDTETESLFRVIRELKSQGRGIVYISHRMKEIFEICDDVTVFRDGQFIAEREVASLTEDSLIEMMVGRKLEDQYPHLDKAPGDIRLKVDNLCGPGVNDVSFTLRKGEILGVSGLMGAGRTELMKVLYGALPRTSGYVTLDGHEVVTRSPQDGLANGIVYISEDRKRDGLVLGMSVKENMSLTALRYFSRAGGSLKHADEQQAVSDFIRLFNVKTPSMEQAIGLLSGGNQQKVAIARGLMTRPKVLILDEPTRGVDVGAKKEIYQLINQFKADGLSIILVSSEMPEVLGMSDRIIVMHEGHLSGEFTREQATQEVLMAAAVGKLNRVNQE
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: O3L2_ARATH
Sequence: MFTAIDKIDRTFTVDQEFACLSSSTSSDSIGENSDDDEGGENEIESSYNGPLDMMESLEEALPIKRAISKFYKGKSKSFMSLSETSSLPVKDLTKPENLYSRRRRNLLSHRICSRGGISKKPFKSVLAMSQREGDSSSSGDDSLPTLRQHHKTLTPRLRKGSFGNCVPVVDSPRCFQTAAGRNIHNIIC
What are the official names of this protein?
Protein OXIDATIVE STRESS 3 LIKE 2, AtO3L2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL33_GLOC7
Sequence: MASKKGVRLIITLECTECRSNPDKRSAGVSRYTTSKNRRNTTGRLELKKFCTHCNKHTVHKEIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PLSC_LIMDO
Sequence: MAKTRTSSLRNRRQLKPAVAATADDDKDGVFMVLLSCFKIFVCFAIVLITAVAWGLIMVLLLPWPYMRIRLGNLYGHIIGGLVIWIYGIPIKIQGSEHTKKRAIYISNHASPIDAFFVMWLAPIGTVGVAKKEVIWYPLLGQLYTLAHHIRIDRSNPAAAIQSMKEAVRVITEKNLSLIMFPEGTRSRDGRLLPFKKGFVHLALQSHLPIVPMILTGTHLAWRKGTFRVRPVPITVKYLPPINTDDWTVDKIDDYVKMIHDVYVRNLPASQKPLGSTNRSN
What is the function of this protein?
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.  This enzyme uses erucoyl-CoA as an acyl donor.
What are the official names of this protein?
1-acyl-sn-glycerol-3-phosphate acyltransferase, 1-AGP acyltransferase, 1-AGPAT, Lysophosphatidic acid acyltransferase, LPAAT.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CAIC_SALEP
Sequence: MDIVGGQNLRQMWDDLAGVYGDKTALIFESCEGIVRQFSYASLNEEINRTANLFYSLGIRKGDRVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLGEESAWILQNSQVSLLVTSVQFYPMYREIRQDNSTPLNHICLIGEQLPADDGVSHFSQLQARQSATLCYTPALSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQIALRDDDVYMTVMPAFHIDCQCTAAMPAFSAGSTFVLLEKYSARAFWDQVRKYQATVTECIPMMIRTLMVQPAAPTDRQHHLREVMFYLNLSEQEKDDFTERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRVGFSYEAEIRDDQNRPLPAGEIGEICIKGIPGKTIFKEYYMQPEATARALEPEGWLHTGDSGYQDEDGYFYFVDRRCNMIKRGGENVSCVELENIISAHPKIQDIVVVGIKDAIRDEAIKAFIVLNEGETLSEAEFFSFCENNMAKFKVPSFMEIRTDLPRNCSGKIIKKNLK
What is the function of this protein?
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.  Also has activity toward crotonobetaine and gamma-butyrobetaine.
What are the official names of this protein?
Crotonobetaine/carnitine--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: PSBJ_MAIZE
Sequence: MADTTGRIPLWLIGTVTGILVIGLIGFFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NICA_PSEPK
Sequence: MQTTISLQVNGQPVEVSAMPDTPLLLILRNDLCLNGPKYGCGLGECGACTVIIDGVAARSCVIPLAGAAGRNITTLEGLGSKAAPHPVQQAFIDEQAAQCGYCMNGMIMTAKALLDRIPEPSDEQIRNELSANLCRCGTHVEILRAVRRAAETRRKP
What is the function of this protein?
Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway.  Mediates conversion of nicotinate into 6-hydroxynicotinate (6HNA).
What are the official names of this protein?
Nicotinate dehydrogenase subunit A, Nicotinate degradation protein A, Nicotinate dehydrogenase small subunit.
Protein: LIAS_DROWI
Sequence: MLRTIKSPIKVIVRPASASASANAEKLDEIRERLAKGPSFQDFIQNPNNTKNEWDNYDGKLRREKVEEQRLRLPPWLKTTIPMGKNYAKIKDQLRELKLSTVCEEARCPNIGECWGGGEHGTQTATIMLMGDTCTRGCRFCSVKTARAPPPLDENEPVNTAKAVASWGLDYIVLTSVDRDDLSDGGSKHIAQTVKEIKARNQNIFVECLVPDFRGDLECVKTIANCGLDVYAHNIETVEKLTPFVRDRRAHYRQTLKVLSEAKRFNPNLITKSSIMLGLGETDAEVEQTMLDLREVGVECLTLGQYMQPTKKHLKVIEYVTPEKFKHWEERGNQLGFLYTASGPLVRSSYKAGEFFITSILANRKKQNDAPK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DCD_ECO55
Sequence: MRLCDRDIEAWLDEGRLSINPRPPVERINGATVDVRLGNKFRTFRGHTAAFIDLSGPKDEVSAALDRVMSDEIVLDEGEAFYLHPGELALAVTLESVTLPADLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNRREDAKYRNQQGAVASRIDKD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: TAM_RHOPS
Sequence: MADWSAEQYLKFEDERTRPARELLAQVPVLAPRKVADIGCGPGNSTELLVERWPQAAVIGVDTSADMLRQARERLPQQKFIEANVAHWAPPPDTDVLFANAVFQWVPDHLKHLKRLVSGLETGGALAVQMPDNLDEPSHILMREVAFEEPWRHQLSKAAESRDMLPKPGVYYDALRPLCSRLEIWHTVYNHVLDDAAAIVEWVKGTGLRPFIDPLDLHERKAYLAAYTARVAAAYPPQADGKVLLRFPRIFFVAIK
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_STAAW
Sequence: MARKQVSRKRRVKKNIENGVAHIRSTFNNTIVTITDEFGNALSWSSAGALGFKGSKKSTPFAAQMASETASKSAMEHGLKTVEVTVKGPGPGRESAIRALQSAGLEVTAIRDVTPVPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: VPS52_MOUSE
Sequence: MAAAATMAAAARELVLRAGASDVEEEEGPLGGGSGLQEPLQLGELDITSDEFILDEVDVHIQANLEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDYIQESENIASLHNQITACDAVLERMEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAKAAAVREQEAMGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQAALLKYRFFYQFLLGNERATAKEIRDEYVETLSKIYLSYYRSYVGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKPSLRSRNTIFTLGTRGTVISPAELEAPILVPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFIVSGPAAHDLFHAVMGRTLSMTLKHLESYLADCYDAIAVFLCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSINQTIPNERTLQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEFIEELLSPPFGGLVAFVKEAEALIERGQAERLRGEEARVTQLIRGFGSSWKASVESLSQDVMRSFTNFRNGTSIIQGALTQLIQLYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHKPNF
What is the function of this protein?
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).  The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.  Acts as component of the EARP complex that is involved in endocytic recycling.  The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 52 homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS52 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
Protein: AK_MYCBO
Sequence: MALVVQKYGGSSVADAERIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLLDLAQQVCPAPPPRELDMLLTAGERISNALVAMAIESLGAHARSFTGSQAGVITTGTHGNAKIIDVTPGRLQTALEEGRVVLVAGFQGVSQDTKDVTTLGRGGSDTTAVAMAAALGADVCEIYTDVDGIFSADPRIVRNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRHNIPVHVRSSYSDRPGTVVVGSIKDVPMEDPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVADADVNIDMVLQNVSKVEDGKTDITFTCSRDVGPAAVEKLDSLRNEIGFSQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGLGGDEEATVYAGTGR
What is the function of this protein?
Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.
What are the official names of this protein?
Aspartokinase, Aspartate kinase, ASK.
What is the protein family that this protein belongs to?
Belongs to the aspartokinase family.
Protein: PPIB_BOVIN
Sequence: MLRLSERNMKILFVAALVVGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDIGRVVIGLFGKTVPKTVDNFVALATGEKGFGYKDSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMDVVRKVESTKTDGRDKPLKDVTIADCGKIEVEKPFAIAKE
What is the function of this protein?
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase B, PPIase B, Cyclophilin B, Rotamase B, S-cyclophilin, SCYLP.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Melanosome.
Protein: CCL3_BOVIN
Sequence: MKVAVAALAVLLCAMALCSQVFSAPFGADTPTACCFSYVARQLSRKIVADYFETSSQCSKPGVIFQTKKGRQVCANPTEDWVQEYITDLELNA
What is the function of this protein?
Monokine with inflammatory and chemokinetic properties.  Binds to CCR1, CCR4 and CCR5 (By similarity).
What are the official names of this protein?
C-C motif chemokine 3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, Small-inducible cytokine A3.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: JAL3_ARATH
Sequence: MVLTSSYSVEGKPASLGPWGGQSGHAWDDGMYTTVKQIIIAHGSGIDSIQIEYDKNGSSVWSEKRGGKGGKKFDKVKFDYPHEYLISVNGTYGSFDVWGTICVRSLTFESNRRKYGPFGVDSGTFFALPKSGSKIIGFHGKAGWYLDAIGVHTQPIPKENNPSSKILLHSHQSFSQGDKKHEYSVLQGSVGQNFDIVVTLRKKDPTLPSFESRDSAGAEVTKHKLVTDTEKSQSKIEGGAKTYGPWGGTGGIMFDDGIYTGIRQINLSRNVGIVSMKVCYDFRGQAVWGSKHGGVGGFKHDKIVFDYPSEVLTHVTGTYGPLMYMGPNVIKSLTFRTNRGKHGPYGEEQGPSFTHQMDEGKVVGFLGREGLFLDSIGVHVMECKISSLKPSSPHNAIVPHNNSGTAQIENSPWANKLVLAANGHGEEVDRGVVKEPTPSGPGPWGGDGGQAWDDGVFSGIKQIFVTRGNDAITSIQIEYDRNGQSVWSIKHGGDSNGVATHRIKFEYPDESITCISGYYGPLNNSDRYNVVKSLSFYTSRGRYGPYGEETGTFFTSTTTQGKVLGFHGRSSFHLDAIGVHMQHWLGNNKSYYSRASCFKLF
What are the official names of this protein?
Jacalin-related lectin 3, Mannose-binding lectin superfamily protein.
What is the protein family that this protein belongs to?
Belongs to the jacalin lectin family.
Protein: H2N01_CYRHA
Sequence: MKVTLIAILTCAAVLVLHTTAAEELEAESQLMEVGMPDTELAAVDEERLFECSVSCEIEKEGNKDYKKKKCKGGWKYKFNMCVKV
What is the function of this protein?
Postsynaptic neurotoxin.
What are the official names of this protein?
U4-theraphotoxin-Hhn1f, U4-TRTX-Hhn1f, Hainantoxin-II-14, HNTX-II-14.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL31_GLAP5
Sequence: MKQGIHPNYVEITATCSCGNVIKTHSTVGKDLNLDVCGNCHPFYTGKQRVVDTGGRVERFNKRFSIPSTK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: PANB_BARHE
Sequence: MTIHKAVKRITASEIRSRKGQEPIVSLTAYQAYSARIADPYCDLLLVGDSVGMVVHGFETTLPVSLDMMILHGQAVMRGSKRALVVVDMPFGSYEESPEQAFSNASRILAETGCSAVKLEGGVYIAETIDFLCKRGIPVMSHVGLTPQAVNRFGGFKTQGRNESNWQQIEADAAAIEKAGAFAVVVEGVVEPLAVKLTQMLSIPTIGIGASSQCDGQILVMEDMLGYGTWVPKFVRRYGVLEQEMEKAIKSYADDVKSRTFPSDEEIYKLKQKSG
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_STRSV
Sequence: MIFDQEDYKAFDPEIWEAVAKEEERQQHNIELIASENVVSKAVMAAQGSILTNKYAEGYPGRRYYGGTDVVDVIEGLAIERAKEIFGAKFANVQPHSGSQANCAAYMALIEPGDTVMGMDLSAGGHLTHGASVSFSGQTYNFVSYSVDPETELLDFDAILQQAKEVQPKLIVAGASAYSHIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPVPYADITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLEHVVAAKAVAFKEVLDPAFKVYAQQILDNAQAMAQVFRQHDKFRVISDGTENHLFLVDVTKVVENGKVAQNLLDEVNITLNKNSIPYETLSPFKTSGIRIGTAAIAARGFGVTESIKVAELIIKALENAENEAVLNQVRAEVRELTDAFPLYEGLN
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB2_MOUSE
Sequence: MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRVIDKDGIHNLENIAFPKRDS
What is the function of this protein?
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit beta type-2, Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I, Proteasome component C7-I.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: RS8_MARMS
Sequence: MSMQDTLADMFTRIRNAQMAAKTSVSMPSSKMKSSIAAVLREEGYVGDFSVDEAVKPTLTIELKYYEGKPVIEQIKRASRPSLRQYKGTSALPKVEAGLGVAIISTSKGVMTDRAARAAGIGGEVICTVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RL23_LACJO
Sequence: MDARDIILRPVVTEKSMNLMDDKKYTFDVLVSATKTQVRNAIEEIFDVKVKNVNIMNVRGKEKRVGRYTGKTARRRKAIVTLTEDSNDIKIFNDNKEN
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: LLDD_PSEPK
Sequence: MIISASTDYRAAAQRKLPPFLFHYADGGAYAEHTLRHNVSDLAGIALRQRVLNNMSELSLETKLFDETLSMPVALAPVGLTGMYARRGEVQAARAAAAHGIPFTMSTVSVCPIEEVAPAINRPMWFQLYVLKDRGFMRNALERAKAAGVKTLVFTVDMPVPGARYRDAHSGMSGKNGPLRRVLQAMTHPEWAWDVGVMGRPHDLGNISKYRGNPTGLADYIGWLGNNFDPSISWKDLEWIREFWDGPMIIKGILDADDARDAVKFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDLKILADSGIRSGLDVVRMIALGADTVLIGRAFLYALAVHGQAGVKNLLELFEKEMRVAMVLTGAKSISEITRDSLVRELGA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GAL1_LACP3
Sequence: MNSTDVTKGFTEQFGKQAEHTFFAPGRINLIGEHTDYNGGHVFPCAISLGTYAAVGTNEDNAFRLYSANFPKVGIIDIPFSDLFQDKRGLWTDYFQGMARVMKTAGANFTHGLNVYINGNLPDGAGLSSSASLEMLVGTILNNLFDGGFEPLELVQFGVKVENDYIGVNSGVMDQFAIEMGRANQATLLDTNTMKYEYLPVEMGDNVIVIMNTNKRRELADSKYNERRSECEKALAMLQKGIEVKSLGQLSEDEFDENTYLIYDPILIKRARHAVFENQRTLKASKALQDGDLKTFGKLVSASGVSLAFDYEVTGIELDTLVTNALKQRGVLGARMTGAGFGGCAIAIVNSADVEDFIDNVGKAYREKIGYDAHFYVADIADGARQLN
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_PIG
Sequence: PRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASPNDTFVHVTDLSGXESICRVTGGMKMKADRXEXSPYXAMLAAQAV
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: LMX1B_XENLA
Sequence: MDIATGPESLDRCFTRGPSDCAKMLDTIKMEDHPLRTGTATLGVLLGSECQHQAVCEGCQRPISDRFLMRVNEASWHEECLQCTVCQQPLTTSCYFRDRKLFCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLSCFCCCVCERQLRKGDEFVLKEGQLLCKSDYEKEKDLLSSGSPDDSDSVKSDDEEGDVKPGKGRVNQGKGSDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKIKKLARRHQQQQEQQNSQRLGQEVMSSRMEGMMTSYAPLAPSQQQIVTMDQNSYSTDPFQQGLTPPQMPGDHMNPYGNDTIFHDIDSDTSLTSLSDCFLASSEVTSMQARVGNPIDRLYSMQSSYFAS
What is the function of this protein?
Required for early specification of the kidney glomus, lying upstream of wt1 in the pathway controlling glomus differentiation.  The balance in levels and expression patterns of binding partners such as lhx1/lim-1 influences differentiation into glomus or tubule derivatives.  Involved in specification of serotonergic neurons.
What are the official names of this protein?
LIM homeobox transcription factor 1-beta.1, LIM homeobox protein 1b, Xlmx1b.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYC_UREPA
Sequence: MKLYDSYSNQLVEINDELISIYNCGPTVYNHIHIGNARPLITMDVLYRFLKKHNIKTKYVLNITDIDDKIINYALANNLKELEVSEYYFNEYLKIKKALNTLEMINPKVSTHMDKIIDYIQKLIDKQAGYFIGDDVYFDTKKALNYGQLSKRDLENDIVGMRIESAANKHNPNDFILWKKTNKGIMWNTPWGIGRPGWHSECSCLINTYIGEQVSIHGGGIDLKFPHHENENAQNQVLYNKNLAKVWMHFGLVNINNEKMSKSLNNFILVKDLLAEYDYQVVRWFFYQADYKQPIKFSHEIMKQNEKEILKIKNAIYNAKNYLYFNNQLKSLTQIDHFELFDERINDDLDFVGIVDLIHISVKKINILIKENKDMNELKLNLTQLLYMLDILGINFVDLHNDENLALLNTWKNYVDKKDYVKADELRKQLINIGIL
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.