PharMolix/UniProtQA huggingface dataset:
Protein: THIC_BURP6
Sequence: MNANPKFLSADARVDAAAVAPLPNSRKVYVTGSQPDIRVPMREITQADTPTSFGGEKNPPIYVYDTSGPYTDPDAKIDIRAGLPALRQRWIDARGDTETLAGLTSDYGRERAADPATAELRFPGLHRHPRRAKAGKNVTQMHYARQGIITPEMEYIAIRENQRRAEYLESLKASGPNGAKLAAMMGRQHAGQAFGAAAFGANAPAEITPEFVRDEVARGRAIIPANINHPETEPMIIGRNFLVKINANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTANRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEEICEIMKAYDVSFSLGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQVMIEGPGHVPMQLIKENMDLQLDWCKEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKEGIITYKLAAHAADLAKGHPGAQVRDNALSKARFEFRWQDQFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQDVREFAAQQGVSENDALKKGMEVKAVEFVKSGSEIYHRQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: FABZ2_LACLA
Sequence: MTEVNINVTEIMEALPHRYPFLLVDRVIDIAEDEITAIKNVTINEEFFQGHFPQYPVMPGVLIMEALAQAAGVLELSKPENKGKLVFYAGMDNVKYKKQVTPGDQLVLHAKFIKRRGPIAVVEAEATVDGKLAAKGTLTFALGR
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_ECO5E
Sequence: MAKQSMKAREVKRVALADKYFAKRAELKAIISDVNASDEDRWNAVLKLQTLPRDSSPSRQRNRCRQTGRPHGFLRKFGLSRIKVREAAMRGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: COBS_PSEP1
Sequence: MLPFWIALQFLSSLPVSLPGMPAPREVGRSLLYYPLVGLLFGLLLWLASHLLQGTPSPLHAALLLTLWVLLSGALHLDGLADSADAWLGGFGDRERTLRIMKDPRSGPIAVVTLVLVLLLKFCALWVLVGQGIGAQLLLAPLIGRAAMLGLFLGTPYVRPGGLGQALAEHLPRRAAGWVLLVCVLFCLFLGGWSVLLALAVFAWLRHLMCRRLGGTTGDTAGALLELLELAVVLGLALGL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TYSY1_BACSU
Sequence: MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase 1, TS 1, TSase 1, Thymidylate synthase A, TS A, TSase A.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA1B3_HUMAN
Sequence: MSGEENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRELFSPLHALNFGIGGDGTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAIVQLVNERQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGHPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGAPLLEPAP
What is the function of this protein?
Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF.  The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition.  Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE).  Plays an important role during the development of brain.
What are the official names of this protein?
Platelet-activating factor acetylhydrolase IB subunit alpha1, PAF acetylhydrolase 29 kDa subunit, PAF-AH 29 kDa subunit, PAF-AH subunit gamma, PAFAH subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCKB_DICDI
Sequence: MKYMENNNTSHSKHPFIIGVTGGTASGKTTVCDEIMKRLENKRIAIICLDSFYRPLSKEDRETVASYNFDHPDAFDWSLVENALRDLKDGKDIEIPTYCFKSHSRLEETVGLGDVDVILFEGILSFYTQSLREQMDIKIFVDTDSDTRLSRRVMRDIAERGRSLEGVLYQYEKFVKPAFDDYILPTKKHADVIIPRGADNVVAIDLIVQHISSKLSEKESFRKSQGQLNVNGGSNTASSVNHA
What is the function of this protein?
Catalyzes the conversion of uridine into uridine monophosphate and cytidine into cytidine monophosphate in the pyrimidine salvage pathway.
What are the official names of this protein?
Uridine-cytidine kinase B, Cytidine monophosphokinase B, Uridine monophosphokinase B.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
Protein: RPOB2_CHLRE
Sequence: MTYSILTESIYNFKKKSSLDMQFLSPKNFQIENFTKIHDQTLPLKPFKTNRTAVAVVPPLPIFSPELYKRQNKLKKTQNATIFSMGTSAFKNQVKYNLETYHRSNQDTCLIHKPAVKEGDWVEVGDLLADSASSIGGELAIGHNIIVAYMPWEGYNYEDAILINERLVYEDIYTSIHIERYEVTTKETKLGFEQITREIPDISENEIKHLDKTGIAKIGSWVEEGDILVGKITPFNIKTLTPQQKLLYKIFDKQLSTTKDSSLRAPKGIKANVININILARQKIQINTKSKNTGKGSKPPRASKAQNTMVSQPSYIHIYLAEKRKMQVGDKMAGRHGNKGIVSRILPRQDMPFLPDGAAVDIVLNPLGVPSRMNVGQIYECLLGLAGRYLGEHYKIPPFDEMYGADASRSFVLSKLYEARKKTGLKWLLDPNHPGKIRLFDGRNSECFDQTVTVGIAYVLKLVHMVDDKMHARSTGPYSLVTQQPLRGRSKQGGQRLGEMEVWAIEGYGAAFVLSEMLTIKSDDMTGRQNLWKNLIENKEISLGSPESFKVLICELQALCLDIGLFRKNKETSLPYFKMPGEESKTNVNANLTGVQSSKKLEANSQTVKNSSMPNLVEIDNLLNLA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta C-terminal section, PEP, Plastid-encoded RNA polymerase subunit beta C-terminal section, RNA polymerase subunit beta C-terminal section.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PNCB_NITHX
Sequence: MTVTDIATRTYNHGWRLDPIVRSLLDTDFYKLLMLQMIREFYPNEHVTFSVINRSRHVRLAEAIDEGELRAQLDHARSIRFSKNELIWLAGNTFYGKTQMFSPDFIDWLATFRLGEYELRKVDGQYELHFHGPWTHTTMWEIPALAILNELRSRQVTKGQGRFALDVLYARAKAKLWAKVERLRKLDDLWLSDFGTRRRHGFLWQRWCVEAAKEGLGPAFTGTSNVLLAMDNDLEAIGTNAHELPMVAAALADDDTALRRAPYRILDQWRHTYGGNLLVALPDAFGTQAFLRDAPEWVADWTGFRPDSLPPIAAGEEIIKWWKQKSRDPREKLLVFSDGMDVDSIEETYHHFAGRVRVSFGWGTNLTNDFVGCSPDGTVDLDPISIVCKVTSVNGRPAVKLSDNPEKATGEPSEIERYLRVFGSAGRVRAPVHV
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: MTA70_ORYSJ
Sequence: MEAQADAGGDDLAAMREQCRSLEEAIGFRRETQMGLVASLQRLVPDLVPSLDRSLRIIAAFNDRPFVPTPNPDGGHGKSPAALKPHHRRALPDPARSTRRKTSPGSSPASVAAAPGGLDAVRTMVAVCLLELVPFAEIDAAALARRLQAESSSASEAERTALADLAAELGGSAASAVVLALRRIAEDTGGVQIEEAMIGGKSMTMVWAIDRNKLLKELPESATLPLLQPPPAPQMPPSETDAGSAMIPRTPQQQQPQPDMWPHSMPPIFPRPRGMTMQGMQRVPGVPPGLMPLQRPFMGPAGVITMGGGVGPSPNQQKQKSEEDELKDLELLLNKKTYREKQNTKTGEELLDLIHRPTAKETAVAAKFKTKGGSQLKEYCTNLTKEDCRRQSGSFVACDKVHFRRIIAPHTDTNLGDCSFLDTCRHTKTCKYVHYELDQTPDIPPMMAGALAPPRQIRLQRAEYCSEVELGEAQWINCDIRNFRMDILGQFGVIMADPPWDIHMELPYGTMADDEMRTLNVPALQTDGLIFLWVTGRAMELGRECLELWGYKRVEEIIWVKTNQLQRIIRTGRTGHWLNHSKEHCLVGIKGNPLVNRNIDTDVIVAEVRETSRKPDEMYPMLERISPRTRKLELFARMHNAHAGWLSLGNQLNGVRLVDEGLRARYKAAYPDSEVQPPSPPRASAPIDGDQGTSQKPTVSDGERPA
What is the function of this protein?
Probable N6-methyltransferase that methylates adenosine residues of some mRNAs.  N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation (By similarity).
What are the official names of this protein?
Probable N6-adenosine-methyltransferase MT-A70-like.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TMM81_HUMAN
Sequence: MKVLATSFVLGSLGLAFYLPLVVTTPKTLAIPEKLQEAVGKVIINATTCTVTCGLGYKEETVCEVGPDGVRRKCQTRRLECLTNWICGMLHFTILIGKEFELSCLSSDILEFGQEAFRFTWRLARGVISTDDEVFKPFQANSHFVKFKYAQEYDSGTYRCDVQLVKNLRLVKRLYFGLRVLPPNLVNLNFHQSLTEDQKLIDEGLEVNLDSYSKPHHPKWKKKVASALGIGIAIGVVGGVLVRIVLCALRGGLQQ
What are the official names of this protein?
Transmembrane protein 81.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: KIF1A_MOUSE
Sequence: MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKPRTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADAGPSADEVNNNTCSAVPPEGLMDSPEKAALDGPLDTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGACMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDEALIDPNILSLNILSSGYVHPAQDDRVFFGNDTRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLETTQRPGPEVLSPASSEDSESRSSSGASSPLSAEGQPSPLEAPNERQRELAVKCLRLLMHTFNREYTHSHVCISASESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPELLPELDSKKTPSPVRATETEKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQANSDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV
What is the function of this protein?
Motor for anterograde axonal transport of synaptic vesicle precursors (Probable).  Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons.  The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites (By similarity).
What are the official names of this protein?
Kinesin-like protein KIF1A, Axonal transporter of synaptic vesicles.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, axon. Cytoplasm, perinuclear region. Synapse. Cell projection, neuron projection. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (PubMed:7539720). Expressed in distal regions of neurites.
Protein: BIOD_BURP1
Sequence: MSAPLSLFVTGTDTEIGKTFVSAALLHGFARAGLRAAAMKPVAAGAYERDGAWRNEDADQLDAAANVALPAAIRTPFLLKAPAAPHIVAAREGVALDIGTIVDAHRRACEMADVIVVEGVGGFRVPLADTRDTADLAVALGLPVVLVVGVRLGCISHALLTAEAIAARGLPLAGWVANRIDPAMPFADDNVDTLRAWLEREHRAPLLGALAHMSPPSPDAASHALDVNLLLNALRAAAPR
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_CHLL2
Sequence: MESKSFSKPTRTATVIVGTQFGDEGKGKLVDYLSDKYDIVVRYQGGANAGHTICFDNKSVVLHLIPSGIFHEGCVCVIGNGVVIDPVALLEEIKKVEELGYDVKGRLFISHNAHLIMPYHKRLDSLHEDAQGEQKIGTTGRGIGPSYEDKFARKGIRVVDLLSPDVLQEKLRENLAAKNKLFRNIYEKEEFDVEELVRDYSEFDKIIDPYVTNTQLYLSRQLKAGKTVLLEGAQGCLLDVDHGTYPYVTSSNPTSGGACTGSGIAPNYVGKVIGVVKAYMTRVGNGAFPSELFDETGESLCRIGHEFGATTGRKRRCGWIDLVALRYSLTVNGVTEIALTKLDVLDTFEEVKVCTSYMLDGKEIHDFPTDHPTLSRVTPVYKTLKGWMSSNAHARTLDDMCPEARSYVTFLEDELQVPVTFVSVGPGREETVYR
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_BACAC
Sequence: MGVERIKAAFENGKKAFIPYVMGGDGGLEILKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCMEAGVDGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERIKKITSESEGFVYAVTVAGVTGVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEKREEICEFIQATKQKEEA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: CD276_RAT
Sequence: MLRGWGGPSVGVSMGTALGVLCLCLTGAVEVQVSEDPVVALVDTDATLRCSFSPEPGFSLRQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLVQGNASLRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNKDLRPGDMVTITCSSYQGYPEAEVFWKDGQGLPLTGNVTTSQMANERGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLVILLVALAFVCWRKIKQSCEEENAGAEDQDGDGEGSKTALRPLKHSENKEDDGQEIA
What is the function of this protein?
Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection.  May play a positive regulatory role in bone formation and has a dual role in the bone-immune interface.  Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells (By similarity).
What are the official names of this protein?
CD276 antigen, B7 homolog 3, B7-H3, Costimulatory molecule.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. BTN/MOG family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: UBIA_THIDA
Sequence: MTLTERLSLYEKLARLDKPIGILLLLWPTLWAQWLASNGDPDWLILWIFVMGVVLMRSAGCVVNDYADRDFDPHVARTRDRPIAAGKVSPKEALLLAAGLSLLAFLLILPLNALVLKLSLIALFLAGSYPFTKRFFAIPQAYLGVAFGFGIPMSYAALWGEVPAEAWLLLAANVFWAIAYDTEYAMVDRADDLKIGIKTSAITFGRFDLTAIAFCYAATLALLAWVGALRDFSGWYYAGLAAAGAIAVYHLRLIRERDPRQCFRAFLHNTWFGAAVFGGIVLHFLLRSGSLFP
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GYRB_CHLPN
Sequence: MDPKEKNYDASAITVLEGLQAVRERPGMYIGDTGITGLHHLVYEVVDNSIDEAMAGYCSRIDVRILEDGGIVIVDNGRGIPIEVHERESAKQGREVSALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKLVATVFKDKKCYQMEFSRGIPVTPLQYVSVSDRQGTEIVFYPDPKIFSTCTFDRSILMKRLRELAFLNRGITIVFEDDRDVSFDKVTFFYEGGIQSFVSYLNQNKESLFSEPIYICGTRVGDDGEIEFEAALQWNSGYSELVYSYANNIPTRQGGTHLTGFSTALTRVINTYIKAHNLAKNNKLALTGEDIREGLTAVISVKVPNPQFEGQTKQKLGNSDVSSVAQQVVGEALTIFFEENPQIARMIVDKVFVAAQAREAAKKARELTLRKSALDSARLPGKLIDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEIGTIIAALGCGIGADNFNLSKLRYRRIIIMTDADVDGSHIRTLLLTFFYRHMTALIENECVYIAQPPLYKVSKKKDFRYILSEKEMDSYLLMLGTNESSILFKSTERELRGEALESFINVILDVESFINTLEKKAIPFSEFLEMYKEGIGYPLYYLAPATGMQGGRYLYSDEEKEEALAQEETHKFKIIELYKVAVFVDIQNQLKEYGLDISSYLIPQKNEIVIGNEDSPSCNYSCYTLEEVINYLKNLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLIHVSLKDAVEADHIFTMLMGEEVPPRREFIESHALSIRINNLDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3408_BRUSU
Sequence: MLRYCLHRLLIGLGMLLALTILIFVLLQLTPGDPIDAYINPNVAMTQAEMDALRAQLGLDRPLPVQYLAWLGQAVQGNLGHSLQRFNETVSGLIASRIGPTLLLMAAGLAIAIVIGVTTGIISAVRRNSFLDYSFSVLALLGISSPAFLTALLGLYVFSVRLKWAPSGGMLTPATDFSIPDLLRHLALPALVLSIGHAALIMRYMRSSMLETLNQDYVRTARAKGVREFWVVVKHTLRNAMLPVVTLIGSTIGLAVGGAIFIESVFNWPGMGLLLINAVETRDYPVIMGATLVIGACVIIVNILTDLAYAVIDPRIKVT
What is the function of this protein?
Probably part of an ABC transporter complex that could be involved in peptide import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Putative peptide permease protein BRA0408/BS1330_II0405.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DPHB_METM6
Sequence: MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKVEETLQKPITVLNREKVEYETNKLIEEAKNKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGITGLQLYKFGKTTSVVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGLDTLLKIEEKRNEKVISGETYAAVVARAGSTKPGLYYGKIKDLINYDFKSPLHCVIIPGKLHFMEEDALKYLFENI
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: SYGB_METNO
Sequence: MPDLLLELFSEEIPARMQRRAAEDLRKLVTDALVERGFLYEGAKAFATPRRLALHIAGLPTRGKDVREERKGPRVGAPEAAIQGFLKSAGLTSLADATVVADPKKGEFYVAVIERPGRDTIDVLAEILPAVIRNFPWPKSMRWGAASTEPGSLRWVRPLHSIVASFGPETETPERVPFAIDGIEAGFTTYGHRFLAPGPIEVRRFADYLPALERARVVLDADRRRDIILHDARDLAFARGLDLVEDEGLLEEVAGLVEWPVTLMGSFDESFLDIPPEVIRATIRANQKCFVLRAPSQDGRERLANAFILVSNLAASDGGAAIVAGNERVVRARLSDAKFFWETDKKVPLESRLPKLKDIVFHEKLGTQGARVERIAALARNLAPLVGADAGLAGRAARLAKADLVTEMVGEFPELQGLMGRYYAELQGEPAAIATAIEEHYKPLGPSDRVPTEPVSVAVALADKLDTLVGFWAIDEKPTGSKDPFALRRAALGVIRLVLAGDVRLPLLGAFAQAVAGHAAVGPESFAADLLGFFADRLKVHLRDQGARHDLIDAVFAIPGQDDLLMIVRRVEALGRFLDTEDGRNLLAGFRRAANILRIEEKRDGRAYDAAPDPALFSLPEESALANALDAARARAAEAVAAEDFEGAMRALATLRPPVDAFFDKVTVNAEDAALRANRLALLNALREATRAVADFARIEG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETN_SACHY
Sequence: MDIVSLAWAALMVVFTFSLSLVVWGRSGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: KANK4_MOUSE
Sequence: MEKIDGKDQSSQGDEEKEPPKSYPYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRAKQAKFSTLPRNFSLPNSGDRTYAVPPQQNWSPVVPRKISLGTQEPSQPLPLGDLPQASVQGSELNYHRKALLAKDARQAEAGSLEDVGSGRPQLLRASSMPATLLQNQVPEEPSLTSGPSTLLALPLLQDEGSVCDGAFDPAEGLMGFQASAQSVDRELGELEPAIPEQVWEGAEPEEGDLKASSHLSQPGPSSAVQSVPMDLEEVEIEHHMREAELVLTPGSATPSPPPLPSPILENDLSLDEIELSISEIPPPPPIEVDVRSIGIRVTEESLGLLETDTSSISSLKNQVLALEDKLSGRTEELARVRAALEQQEEETKAREQRIQELECTVAHLEEKLSQERASEAPDRTDATVNTDPLQELTPRESHDKNIGVNLLNTPDPECRAPRAEKNGFPWVQNNHKQSYPSPEEPVLPPQLSLPRGPEQILASSLCSCLSMELRIEEEGSEQEGGQEEGAGGLSRAAGESSWSTRESAPVIREEATSELPGAERPGRPASSPQDATIGQYVKKIQELLHEQWNCLEHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEPEPKETPAPPPSTPPPPPPPPPEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSSPEDLSDSETEKKQDCSESREDRDLHPSCEAGQGVPEGTRNSGHTSDRGEEVSHLRAERYKPSEEFLNACQTLSQHLPETGDTTKQLLRQSLNTISQEWFRVSSRKLSSPEAVAAYLLEVQPHSPYLLKLLVNLADRSGNTALHYSVSHSNFAIVKLLLDTGVCNVDHQNKAGYTAVMITPLASAETKEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDNDGSSALMLACHQGNADLVRLLLAHPACNSSLTDKAGRTALSLVLNSPAHVEIAELLRAHSEPGRSLGPKELQKN
What is the function of this protein?
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
What are the official names of this protein?
KN motif and ankyrin repeat domain-containing protein 4, Ankyrin repeat domain-containing protein 38.
What are the subcellular locations of this protein?
Cytoplasm.