PharMolix/UniProtQA huggingface dataset:
Protein: ATG4_DEBHA
Sequence: MSNRDSSEHGDSSNKIASNECNEATKLGFNFTQLWSQITTTYSLIDRNDSNMFNRDERVESEQEKKSVVILGKKYDDISVDDGVIEQDIYSKIWLTYRTGFEPIAKCLDGPQPLSFVQSMVFNRNPISSTFNNFHGLLDNDNFTTDVGWGCMIRTSQALLANTYQLLFLGRGFSYGRDRSPRHDEIIDMFMDEPRAPFSLHNFIKVASESPLKVKPGQWFGPNAASLSIKRLCDNVYESNGTGRVKVVISESSNLYDDIITQMFTTLNPVPDAILVLLPVRLGIDKVNPLYHASVLELLALRQSVGIAGGKPSSSFYFFGYKGNDLLYLDPHYPQFVRNKTSVYDTYHTNSYQKLSVDDMDPSMMIGILIKDINDYEDFKSSCTKSSNKILHFHPTSEKADRRGSLSEFKRKNSEFVCIESKDVQRREDFITIDNVSRDDLNNMEGFIDMADEFDSEIDQNNKDDNFDDDEPVNVSQTSIGEEYTSTAGSRP
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: C4D10_DROMT
Sequence: MSLSLPPLIAVACLVVALARISWLPLRSWLRRRRRTHQLAAQLPGPRNLPLLGNFHMFFGLEPWQVPHLINQLAKKYDGTFKLKMGSNFSLMMFQPRDIEVVLGSSQLLDKAVEYSFLRGWLNDGLLLSGGRKWHRRRKIITPAFHFRILESYDEIFDRQTRLLIHKWQQTLGHSFDLGHDVHLFTLDVICETAMGVSTNAQTNADSDYVRAVKTISTVLHKRMFNIFYRFDLTYMLTPLAWAERRALNVLHKFTEKIIVQRREELLRGGVTQTTDGADVGAKSKMVFLDILLQSNIDDKPLTNLDIREEVDTFMFEGHDTTSSGITFFFYNIALYPECQRKCVEEIVSVLGKDTETPVTYDLLNNLNYMDLCIKETLRMYPSVPLLGRKVLQECEINGKIIPAGTNIGISPLFLGRSEDISSEPNTFKPERFDVVTSAEKLNPHAYIPFSAGPRNCIGQKFAMLEIKAIAANVLRHYEIEFVGNAEESPVLIAELILRTKDPLMFKLKKRVI
What is the function of this protein?
May play an important role in the maintenance of specific insect-host plant relationships.  May be involved in xenobiotic metabolism.
What are the official names of this protein?
Cytochrome P450 4d10, CYPIVD10.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: SYV_STAS1
Sequence: MEMKPKYNPREVESGRYDQWVNSGYFKAKDDQSKETYTIVIPPPNVTGKLHLGHAWDTTLQDILTRMKRMQGYDTLYLPGMDHAGIATQAKVEAKLNEQGLSRHDLGREKFLEQAWDWKEEYANFIRQQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDMYNKGLIYRGEYIINWDPIARTALSDIEVIHEDVQGKFYHFKYPYADGNGYIEIATTRPETMLGDTAIVVNPNDERYKDVIGKTVILPIVGRELPILADEYVDIEFGSGAMKVTPAHDPNDFEIGNRHDLERIIVMDESGKMNDKADKYQGMDRFDCREQLVKDLEAENLVIKIEEHEHSVGHSERSGAVVEPYLSTQWFVKMKPLAEQALNNQKTDDRIDFVPARFEKTFNRWMEEIRDWTISRQLWWGHQIPAWYHKETGEIFVGEHEPEDIENWVQDEDVLDTWFSSALWPFSTLGWPDVEADDFQRYFPTNALVTGYDIIFFWVARMIFQGLEFTGKRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKVESIWNFINKIWNAARFSIMNIGEDFTVEQVDLSGDLSLADKWILTRLNETIENVTELSDKYEFGEVGRTLYNFIWDEFCDWYIEMSKIPMNGEDEAQKQITRSVLTYVLDNTMRMLHPFMPFVTEQIWQNLPHEGETIVKAAWPKVNEALVFDDSKETMQQLVEIIKSVRQSRLEVDTPLSKAIPIFIKAKDENIKETLLNNSNYIDRFCHPSELTIDTTIEIPEKAMTSVTTAGEVVLPLEGLIDMDKEIARLENELLKWEKELDRVNKKLANENFVNKAPEKVINEEREKKQTYQEKYDGVKLRINQLKA
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COPG_DICDI
Sequence: MASRVQKKDDDESDFLFENLDKGQVIQEKRAFNESPIHPRKCSLVISQFLYLLSRGDSFTKTEATDIFFAATKLFQSKDIPLRRLMYLLLKELSTISQDAIIVISSLTKDMSHKIELYRANAIRILCKITDSSILPQIERYFKQSIVEKDPHVSSAALVSSIHLLKVCPEIVKRWANEVQEAISNKSNMVQYHALALLHRIKQHDRLAVSKLVSNLIKNSLRSPYAQSYLIRCCVEVIEETNTEDRIFREYIESCLRSKNEMVAYEAARSICTFKNVSNKEINSAVGVLQNFLNSTKPTLRFAAVRTLNKLAQTNPTAVIPCNLDMENLITDTNRSIATLAITTLLKVGNESNVERLIKQIANFLGDINDEFKIVVVDAITSLSQKFPKKYKHLIIFLNKILRDEGTLQLKQATLDAILTVVNNIPESKEIALTELCDYIEDCDFPDLSVQILHLIGQEGPLTSSPAQYMRYIYNRVLLDGGIIRAAAVTSIAKFGLLYEPMKEKVVILLQRCLLDEDDEVRDRATLYLKLFKENDVRYLNKVLMDDVPVPLNNLQKSLELYLHQGDFSEPFDIASVSTVVETYQSPLLGDGKSPFSTGASKKGDSVTGTPKSNNASNNNNNNEESSGPESFATKLSQIPQFSTFGKLLKSSEYIELTETETEYVVNCVKHIYREHIVFQFNCTNTLNEQQLSNVSVKMVPSDPKLLKYECSIPIDVLPYGEPQQCYVAIRYIPANGYPLCSFSNALKFKVKEVDPSTGELDEPGYDDQYSLERLEIVPKDFLNRAFVGNFSEEWKKMSEDTQLVQTFSLVGVKSIDEAVKQIIKTLGMAPAEKSEVVTPKSAKHILYLTGKSLNNQLIYVRARMKLDQSQTNTDVELTIKSDDESLNDFVISAFIEK
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit gamma, Gamma-coat protein, Gamma-COP.
What is the protein family that this protein belongs to?
Belongs to the COPG family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: Y1845_MYCBO
Sequence: MVRLVPRAFAATVALLAAGFSPATASADPVLVFPGMEIRQDNHVCTLGYVDPALKIAFTAGHCRGGGAVTSRDYKVIGHLRAFRDNTPSGSTVATHELIADYEAIVLADDVTASNILPSGRALESRPGVVLHPGQAVCHFGVSTGETCGTVESVNNGWFTMSHGVLSEKGDSGGPVYLAPDGGPAQIVGIFNSVWGGFPAAVSWRSTSEQVHADLGVTPLA
What are the official names of this protein?
Uncharacterized protein Mb1845.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1815.
Protein: VRAX_STAAM
Sequence: MIIYRQYHHEGAPVYEIITKTFQHVSIKCDDSFSDTEIFKLLSLLQDDIDHMKVS
What are the official names of this protein?
Protein VraX.
Protein: SECM_SALPA
Sequence: MSGILTRWRQLGRRYFWPHLLLGMVAASFGLPALSNAAETNTPARTTASTASKVNFSHLALLEASNRRPNFTVDYWHQHAIRTVIRHLSFAMAPQTLPVADAPSPLQAHHIALLNTLSAMLTQEGTPPAIVRRLSLAYFAPQTAFSIPAWISQAQGIRAGPQRLS
What is the function of this protein?
Regulates secA expression by translational coupling of the secM secA operon.  Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
What are the official names of this protein?
Secretion monitor.
What is the protein family that this protein belongs to?
Belongs to the SecM family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Protein: PYRG_SHIFL
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVETRGVEILKGLDAILVPGGFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANSTEFVPDCKYPVVALITEWRDENGNVEVRSEKSDLGGTMRLGAQQCQLVDDSLVRQLYNAPTIVERHRHRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAASEFQKRQAK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: FTRA_ASPFU
Sequence: MAKDVFAVPIFFICFRECVETSIIVSVLLSFIKQTLGQEQDATTRKRLIRQVWWGVAIGLFISVCIGAGMIGAFYGYGKDHFASTEDLWEGIFSLIASVIITIMGAALLRVTKLQEKWRVKLAQALEAKPLTGGTFKNNLKLWAEKYAMFLLPFITVLREGLEAVVFIGGVSLSFPATAFPLPVFTGILAGVAIGYLLYRGGNQASLQIFLIISTCILYLVAAGLFSRGVWYLENNTWNHVIGGDAAETGAGPGSYDIRQSVWHVNCCSPLVNGGGGWGIFNAILGWTNSATYGSVLSYNLYWIAVIVWFVAMRHKERHGRLPVVDPLLNRLRGRKSAEPGNGEQDVEVSTIPSDLQTESKIPKSGASLV
What is the function of this protein?
High affinity iron permease; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism (PubMed:15504822).
What are the official names of this protein?
High affinity iron permease ftrA.
What is the protein family that this protein belongs to?
Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EF1B_THEKO
Sequence: MSDYNLVGVIKVMPTDPDVNLDELEEKLKAVIPEKYGLAKVEREPIAFGLVALKFYVLGRDEEGYSFDEVADIFRQVENVESAEVETVSRI
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: DER_MARMS
Sequence: MIPVIALVGRPNVGKSTLFNQLTRSRDALVADYPGLTRDRKYGDGKLGEHEFIVIDTGGISGDEQGIDEKMARQSLLAIEEADVVLFLVDGRHGLNPADEMIASHLRRSNKQVSLVVNKTDGINEDIALADFYSLGFGELHPIAASHGKGVHVLIDKVMLPFAERVEEAKNQISIESRGIRIGVVGRPNVGKSTLVNRMLGEDRVVVYDMPGTTRDSVYIPYVRNDKEYTLIDTAGIRRRKHVKEAVEKFSIVKALQAIQDANVVIVVIDSHENLVEQDLHMIGYVLDAGRGVIIAINKWDGLKKDDREHIKSEVERRLGFVPYAKVHYISALHGTGVGDLYDTIESTYESCYAKWTTNRLTRILEDSIAEHQPPMVNSRRIKLRYAHQGGSNPPRIVVHGNQTDSLPGSYKRYLENKFRTVLNITGTPIIFEFKSAENPFAPKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ZN672_RAT
Sequence: MFTAPGVAATRERPYSCSVCGKSFQYSAVLLRHERAHGGDKRFRCLECGERCARASDLRVHRWTHAGQTLYICSECGQSFSHSSLLDLHLGTHRRRSSTCPCRLCGRRFPHVSALLLHRVRQHPPEKPHRCPLCARSFRQSALPFHLARAHPPETTIATAPAPSTLYHCTQCPRAFHSSAGLRNHSRIHVVPSLSDPGAEAHRCGVCGKSFSKSSTLTRHLQRHSGEKPFKCPECGKGFLESATLVRHQRTHTGEKPYACNDCGRCFSESSTLLRHQRSHQGERPHICATCGKGFGQRYDLVVHQRSHTGERPFPCPECGRGFTDRSDLTKHLRTHTGEKPYHCELCGKRFTCISNLNVHLRNHAGHKPHKCPECGKSFSVASKLALHRKTHLGERTAECTECGKFFSHGRSLSQHQRSHRRARAAAMAATTTTTVVTEMTIGPSLTLTGPTEQEKSGLLVSTFQETC
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 672.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYK_THEVO
Sequence: MFWADAAVKDLIGEQRISTGISPSGPIHVGNMREILTGDILYKAVIKRGLKSDFIYLCDDMDPLRKVYPFLDQSYSKYVGFPLKNIPSPDGVGVYSDHFLNPFIEVMRKTGIPARVIKTSDLYGNGILADAIDTVMERRSEIKDILEKITGRMIEGDFYPYEPLCEKCGRINSTSVISYKYPYAEYTCKCGHHGFADIRRAEGKMPWRIEWPAKWYALKVSIEPFGKDHGAPGGSYDTGKRIAREIFGIEPPLPLVYERIMLKGKGAMHSSTGLAIPASEIIDVMPPELLRFLIARVNPSRHIDFDPGLGLLNLFDEFERYLNKYREGDIDGDSKAIIEYSLIEKEKLSYPIDFRHLITLIQIYQKKEDILRAAMASTKDQLDESALYDEIKYAKNWLERYAPDNVKFKLLAIDEKAELSDQDRAILSKFLEVSNSMAWDSNEIHSTVHNVAKDLGIGPDAAFSTFYKVFIGKERGPRLGYFLFNLGKDFTIARIKSVLGGNS
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_SYNR3
Sequence: MTAQQAQRFPGTGLQWSLGLIALILAACLISDGLSGGPQLSLPLLLAGALSWLVCWIGVPRLRALKMGQVIRQEGPQSHQSKSGTPTMGGLLLVPCGVVVGSLVSPGDPRLLPIGLVTLAFMVIGGIDDWRSLTKRHNTGLTPKGKLLLQALAAGLFLLWAGLHGAIPTAIALPWGWLLPIGLLIWPLGLFVFLAESNATNLTDGLDGLAAGVGAIVLVGLSLQLMLRGNGGDPALAGYGAALAGAWLGFLLHNRHPARVFMGDTGSLAMGAALSAIALLSNSLWPLLLMGGLLLAESLSVILQVWVFKATKGADGQGKRLLRMAPLHHHFELGGWSERRVVVSFWGISLLLVALGLVLVP
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TMM43_MOUSE
Sequence: MAANYSSTSSRKEHVKVTSEPQPGFLERLSETSGGMFVGLMTFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKIDNFKALSLAKLEDPHVDIIRRGDFFYHSENPKYPEVGDVRVSFSYAGLSSDDPDLGPAHVVTVIARQRGDQLIPYSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWAALIGCLALVPIIIARTRVPAKKLE
What is the function of this protein?
May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane.  Required for retaining emerin at the inner nuclear membrane (PubMed:18230648).  Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.  In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity).  Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing (PubMed:34050020).
What are the official names of this protein?
Transmembrane protein 43, Protein LUMA.
What is the protein family that this protein belongs to?
Belongs to the TMEM43 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Nucleus inner membrane; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen.
Protein: LBP_HUMAN
Sequence: MGALARALPSILLALLLTSTPEALGANPGLVARITDKGLQYAAQEGLLALQSELLRITLPDFTGDLRIPHVGRGRYEFHSLNIHSCELLHSALRPVPGQGLSLSISDSSIRVQGRWKVRKSFFKLQGSFDVSVKGISISVNLLLGSESSGRPTVTASSCSSDIADVEVDMSGDLGWLLNLFHNQIESKFQKVLESRICEMIQKSVSSDLQPYLQTLPVTTEIDSFADIDYSLVEAPRATAQMLEVMFKGEIFHRNHRSPVTLLAAVMSLPEEHNKMVYFAISDYVFNTASLVYHEEGYLNFSITDDMIPPDSNIRLTTKSFRPFVPRLARLYPNMNLELQGSVPSAPLLNFSPGNLSVDPYMEIDAFVLLPSSSKEPVFRLSVATNVSATLTFNTSKITGFLKPGKVKVELKESKVGLFNAELLEALLNYYILNTFYPKFNDKLAEGFPLPLLKRVQLYDLGLQIHKDFLFLGANVQYMRV
What is the function of this protein?
Plays a role in the innate immune response.  Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359).  Acts as an affinity enhancer for CD14, facilitating its association with LPS.  Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).
What are the official names of this protein?
Lipopolysaccharide-binding protein, LBP.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule membrane. Note=Membrane- associated in polymorphonuclear Leukocytes (PMN) granules.
Protein: PG086_VACCC
Sequence: MASLLYLILFLLFVCISYYFTYYPTNKLQAAVMETDRENAIIRQRNDEIPTRTLDTAIFTDASTVASAQIHLYYNSNIGKIIMSLNGKKHTFNLYDDNDIRTLLPILLLSK
What is the function of this protein?
Component of the entry fusion complex (EFC), which consists of 11 proteins.  During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation.
What are the official names of this protein?
Entry-fusion complex protein OPG086, EFC protein OPG086, Protein G3.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG086 family.
Protein: FMT_ACIF2
Sequence: MTEKQRIVFAGTPEFARITLAELRQGPEAVVGVFTQPDRPAGRGRTLQASPVKQEALAAGIPVFQPESCKTGEALELLRSLAPDLLIVVAYGQILPQAILALPTRGAINVHASLLPAWRGAAPIARAIAAGDKESGVAIMQMEAGLDSGPVLWEERLPIAADDTAASLHDRLARLGGKALRHVLDDLWAERLKPVPQDPALVTYAHKLKKEEALLDWRLPAATLERLVRAFNPSPVAHTLFRDKGLRVWQARVLGAGGDQAPGSISAVEKDGVVVTCGEDRLQLLAVQPAGKGVLSGSDFARGYRPQVGEVLG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: SMCO4_TAKRU
Sequence: MRQLKGKPKKETSKDKRERKQAMQDARKQVATVVLPTVAVVVLLIVFFVYAATRPGAIA
What are the official names of this protein?
Single-pass membrane and coiled-coil domain-containing protein 4, Protein FN5.
What is the protein family that this protein belongs to?
Belongs to the SMCO4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DAPE_RICRS
Sequence: MYINYLKDLISFKSVTPKSDGAIEYINDLLKQHGFKTEIKIFGDSKSEQVTNLYAVFGSNEPNICFVGHVDVVLEGNHELWHNASPFKVSQQDGKIYGRGAVDMKGAIACFLAASLDFIKNNTDFKGSISFLLTSDEEGKAKHGTKEMLQYIYDQGYKINFAIVGEPTCEKEIGDAIKIGRRGSVNFKLNIEGLSGHVAYPHKANNPLPCLIIILNELTNIKLDEGTEFFQRSNLEVTNIEVSNNTSNVIPASTEASFNIRFNNLHSAETLAKQVEEIIKQHCKEYKVDYKLEYSSSAESFIQNPSDKIKEFAKVVEHTLKIKPEFSTSGGTSDARFVKNYCPLVEFGLLSETAHKINEYTKISDLQKLYDVYYNFLMEIL
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: RL22_STAAE
Sequence: MEAKAVARTIRIAPRKVRLVLDLIRGKNAAEAIAILKLTNKASSPVIEKVLMSALANAEHNYDMNTDELVVKEAYANEGPTLKRFRPRAQGRASAINKRTSHITIVVSDGKEEAKEA
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: TRHO_STRGC
Sequence: MAKDIRVLLYYKYVPIENAEKFAADHLAFCKSIGLKGRILVADEGINGTVSGDYETTQKYMDYVHSLPGMEDLWFKIDEENEQAFKKMFVRYKKEIVHLGLEDNDFDNDINPLETTGAYLSPKEFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVQGELWDGKMYVFDERISVDINHVDPVVIGKDWFDGTPCERYVNCGNPECNRRILTSEENEDKYLRGCSHECRVHPRNRYVAENGLSQAEVVERLAVIGESLETLVAQ
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: MTOX_SALNS
Sequence: MKYDLIIIGSGSVGAAAGYYATRAGLKVLMTDAHMPPHQQGSHHGDTRLIRHAYGEGEKYVPLVLRAQALWDELSTHNEEPIFVRSGVVNLGPADSAFLANVARSAQQWQLNVERLDATALMTRWPEIRVPDNYIGLFEADSGFLRSELAITTWLRLAREAGCAQLFNSPVSHIHHDDNGVTIETSEGCYHASKALISAGTWVKALVPELPVQPVRKVFAWFKADGRYSTKNRFPAFTGEMPNGDQYYGFPAENDELKIGKHNGGQLIQAQEERKPFAAVASDGAEAFPFLRNVLPGIGGCLHGAACTYDNSPDEDFIIDTLPGHENTLVITGLSGHGFKFAPVLGEIAADFALGKTPSFDLTPFRLSRFSQ
What is the function of this protein?
Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.
What are the official names of this protein?
N-methyl-L-tryptophan oxidase, MTOX.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family. MTOX subfamily.
Protein: RL2_BACCQ
Sequence: MGIKKYNPTTNGRRNMTTNDFAEITTDRPEKSLLAPLSKKAGRNNQGKITVRHQGGGHKRQYRIIDFKRNEDGIPGRVATIEYDPNRSANIALINYVDGEKRYILAPKNLEVGMEIMSGAEADIKIGNALPLINIPVGTVVHNIELKPGRGGQLVRSAGTSAQVLGKEGKYVLVRLTSGEVRLVLSACRAAVGQVGNESHELIKIGKAGRSRWLGKRPTVRGSVMNPVDHPHGGGEGRSPIGRKSPMSPWGKPTLGFKTRKKNKASDKFIVRRRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CTU2_CAEEL
Sequence: MELGNFVTDLNGKKCVKCDKDAKFTGVDPKKAWYCQECFVQMVRNKFRSSLSKKKIYKDADARDTLIVFDGTLSGTFLLHQINDALKQITYKRLMVKPTVLVLVSLTEDTEIQMVIKRIQEIKKSVLENVRWVVAHLACSMYDEDFKLKENECNGVEKISDYNQLIASCSVPTYRKELERVLKEKCLQKIACSMGILKCMVPDHADDLGRLAIDQLCLGRGGSISTLVTVTDKRPDFMLIRPLCDISKKELAVYNYLCDIDKHCIHIAQQNNQQKSVQTLTDAFICTLENEKFYSTINTVLSTAAKIHNTSIGKDDSKCSFCNVEVADSVCSTCSAIRECTGDLLTLLF
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2, Thiolation of uridine in tRNA protein 2.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.