PharMolix/UniProtQA huggingface dataset:
Protein: LEU1_SHIB3
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: MIAA_WOLSU
Sequence: MKIFAILGASASGKSALGLRLAKELECFILSLDSLSIYQEINIASAKPSKEELLSIRHFGIDLLTPNEPSNAALFAHLFEEALEASNQAGKKALLLVGGTGFFLKRIIEGLSPAPTLDPSAKEWLKEVLENRREAFKELEKIDPLYTSRITPSDLHRLRRGWEIYLGSGLSPSLFFETHPPKPLGHDLKIYELTLERELLRQRITERTEQMLESGLIDEVCQLESRYTREPQAMKSIGIAETLAYLDGEISKEELTPLISTHTAQLAKRQTTFNKTQFTSIRHLEAPRLFEEICHTITKS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: HMD_METTH
Sequence: MKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRKK
What is the function of this protein?
Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
What are the official names of this protein?
5,10-methenyltetrahydromethanopterin hydrogenase, H(2)-dependent methylene-H(4)MPT dehydrogenase, H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase, N(5),N(10)-methenyltetrahydromethanopterin hydrogenase.
What is the protein family that this protein belongs to?
Belongs to the HMD family.
Protein: LOC1_PICST
Sequence: MAPRQSKTAKRSKTQNKTRANESEVFSDASARNLMANQPKLTEKSKVKKLSKRVVKKQQAKIRLYGAKNGKEYREDQLDIPTLNKAIIPGVRAKKGKKGKKFVDDNDTLTLSRLVKSINDKYDVVNESKLEKSRRLEELRELKKKEIERKEQQKMDKLEGKKSELKNRASVARSNRRKNAKAAKKIEDEETDQPRKKTKSVSFA
What is the function of this protein?
Required for efficient assembly and nuclear export of the 60S ribosomal subunit.
What are the official names of this protein?
60S ribosomal subunit assembly/export protein LOC1.
What is the protein family that this protein belongs to?
Belongs to the LOC1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DRA2B_DEIRA
Sequence: MIRNKAFVVRLYPNAAQTELINRTLGSARFVYNHFLARRIAAYKESGKGLTYGQTSSELTLLKQAEETSWLSEVDKFALQNSLKNLETAYKNFFRTVKQSGKKVGFPRFRKKRTGESYRTQFTNNNIQIGEGRLKLPKLGWVKTKGQQDIQGKILNVTVRRIHEGHYEASVLCEVEIPYLPAAPKFAAGVDVGIKDFAIVTDGVRFKHEQNPKYYRSTLKRLRKAQQTLSRRKKGSARYGKAKTKLARIHKRIVNKRQDFLHKLTTSLVREYEIIGTEHLKPDNMRKNRRLALSISDAGWGEFIRQLEYKAAWYGRLVSKVSPYFPSSQLCHDCGFKNPEVKNLAVRTWTCPNCGETHDRDENAALNIRREALVAAGISDTLNAHGGYVRPASAGNGLRSENHATLVV
What is the function of this protein?
An RNA-guided dsDNA endonuclease.  When guided by an RNA derived from the right-end element of its insertion sequence element (IS), cleaves DNA downstream of the 5'-TTGAT-3' transposon-associated motif (TAM).  Cleaves supercoiled and linear DNA in a staggered manner 15-21 bases from the TAM yielding 5'-overhangs.  Binds reRNA, an approximately 150 nucleotide base sRNA derived from the 3' end of its own gene, the right end (RE) of the insertion sequence (IS) and sequence downstream of the IS (PubMed:34619744).  May cleave at the donor joint (generated by ISDra2 excision mediated by TnpA) to trigger homology-directed repair and restore intact IS in its original position (Probable).  Inhibits transposition activity of the IS200 element; the possible zinc-binding motif of TnpB is required for this inhibition (PubMed:23461641).  Part of IS element ISDra2, this protein is not required for transposition (PubMed:20090938).  The IS element inserts 3' of the sequence 5'-TTGAT-3'; target duplication has not been observed (PubMed:14676423, PubMed:16359337).
What are the official names of this protein?
RNA-guided DNA endonuclease TnpB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transposase 35 family.
Protein: RL15_TRIEI
Sequence: MRLKDAIPKKGSQQRGRRVGRGISAGQGASCGKGMRGQKSRSGGSTRPGFEGGQNPLYRRLPKLKGFPMVNRKKYTIINVSKLSSLPANTEVTLASLIKVGIITTDDGPLKILGDGDLNIPLKVYAAAFTASARSKIEAAGGSCEEIGPAQAVSNEDSTKE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: DAK_PICPA
Sequence: MSSKHWDYKKDLVLSHLAGLCQSNPHVRLIESERVVISAENQEDKITLISGGGSGHEPLHAGFVTKDGLLDAAVAGFIFASPSTKQIFSAIKAKPSKKGTLIIVKNYTGDILHFGLAAEKAKAEGLNAELLIVQDDVSVGKAKNGLVGRRGLAGTSLVHKILGAKAYLQKDNLELHQLVTFGEKVVANLVTIGASLDHVTIPARANKQEEDDSDDEHGYEVLKHDEFEIGMGIHNEPGIKKSSPIPTVDELVAELLEYLLSTTDKDRNYVQFDKNDEVVLLINNLGGTSVLELYAIQNIVVDQLASKYSIKPVRIFTGTFTTSLDGPGFSITLLNATKTGDKDILKFLDHKTSAPGWNSNISDWSGRVDNFIVAAPEIDEGDSSSKVSVDAKLYADLLESGVKKVISKEPKITLYDTVAGDGDCGETLANGSNAILKALAEGKLDLKDGVKSLVQITDIVETAMGGTSGGLYSIFISALAKSLKEKELSEGAYTLTLETISGSLQAALQSLFKYTRARTGDRTLIDALEPFVKEFAKSKDLKLANKAAHDGAEATRKLEAKFGRASYVAEEEFKQFESEGGLPDPGAIGLAALISGITDAYFKSETKL
What is the function of this protein?
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.
What are the official names of this protein?
Dihydroxyacetone kinase, DHA kinase, Glycerone kinase, Triokinase, Triose kinase.
What is the protein family that this protein belongs to?
Belongs to the dihydroxyacetone kinase (DAK) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_THEFY
Sequence: MSRIGRVERATNETKVFVEVNLDGTGAADISTGVGFYDHMLHQIAKHGLFDLTVRTEGDLHIDAHHTMEDTALALGAAFREALGDRSGIRRFADAKVPLDEALAEVTVDISGRPYLVHSEPEGMAPMIGRDYDTTMTRHIFESFVAQARITLHVHVPYGRIPHHIVECQFKAVARALRSACERDPRVTGVPSTKGTL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y641_MYCPN
Sequence: MNKKRLLPKASLGALFMLFGTALTACSNSDFQTNLTSLNQLREGVNQNTSLTQDKKAFVESLQKAFENNPEGTTKVLLDAWKFTLLDSKILESKDPSRFVKAFGSGKSNEDVEPNASVKGLRLDKRFEPSTANIINNVISLNEQKVEAFNIQYKSRTSFKVQVKLNAQGKYQKSQVQSYLQQIGLNDGDLKQESGTLSADLIFTYTVPESNLFSRKNFDTLMKKINFNTTLKIDMVGKDEIMKKILQSTTFTNNLSSQTFQDQSIDLLPYLLYSIL
What are the official names of this protein?
Uncharacterized lipoprotein MG440 homolog 3.
What is the protein family that this protein belongs to?
Belongs to the MG439/MG440 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RM10_DANRE
Sequence: MAATLCCRLLPKAGWVPLTQSVRHGSKAVTRHKKPVHFQKQKLLAVTEYIPPTLSAPPAALAPRVKKTGEESSLAVMLRKDLENLFQEYKMIAVAQNNAISAEDMIHLKHRLKKHAINVKFFPNQVTRSFLNSSIYGNMSPLIFGETVLLASKEPKVKEMLQALRHNPQIVLLGACIENTLFSYQGILSYSKLPSIAIIRGELVSGLTMMTSKTVSMLHHHPAHLSALLQQYVKQQSSADTDKDASIQEAAA
What are the official names of this protein?
39S ribosomal protein L10, mitochondrial, L10mt, MRP-L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ALB1E_PEA
Sequence: MASVKLASLIVLFATLGMFLTKNVGAASCNGVCSPFEMPPCGSSACRCIPVGLLIGYCRNPSGVFLKGNDEHPNLCESDADCKKKGSGNFCGHYPNPDIEYGWCFASKSEAEDVFSKITPKDLLKSVSTA
What is the function of this protein?
PA1b binds to basic 7S globulin (BG) and stimulates its phosphorylation activity.  Involved in the signal transduction system to regulate the growth and differentiation as a hormone peptide.  Toxic to various insects through binding to a high affinity binding site in the insect gut (By similarity).
What are the official names of this protein?
Albumin-1 E, PA1 E, PsaA1b014, Psa.
Protein: NDUV3_GORGO
Sequence: MAASCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKKPAPVPAEPFDNSTYKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.  May be the terminally assembled subunit of Complex I.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial, Complex I-9kD, CI-9kD, NADH-ubiquinone oxidoreductase 9 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFV3 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: NU4M_STRCA
Sequence: MLKIIIPTIMLLPTALLSPKASLWTNTTTYSLLIATISLQWLNPTYFPHKNMTPWTGIDQISAPLLVLSCWLLPLMLLASQNHLQQEPLVRKRTFIVTLTTIQPFIILAFSATELTLFYISFEATLIPTLILITRWGNQPERLSAGIYLLFYTLISSLPLLVTILHLHTQIGTLHMPTLELTHPLLTHSWTGTLSGLALLMAFMVKAPLYGLHLWLPKAHVEAPIAGSMLLAALLLKLGGYGIMRVTLLMGPLTDRLSYPFLALALWGALMTSSICLRQTDLKSLIAYSSVSHMGLVIAASMIQTDWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILLLTRGLQPLLPLMSVWWLLANLTNMALPPTTNLMAELTIMIALFNWSTPTIILTGLATLLTASYTLFMLSMTQRGTLPTHLTSIHNSNTREHLLMTLHIFPMLLLMLKPELISGVI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: RL10_SOLME
Sequence: MGRRPARCYRQIKNKPYPKSRFCRGVPDPKIRIYDVGMKRKGVDEFPFCVHLVSWEKENVSSEALEAARIACNKYMTKSAGKDAFHLRVRVHPFHVLRINKMLSCAGADRLQTGMRGAFGKPQGVCARVAIGQVLLSVRCKDGNSNHAQEALRRAKFKFPGRQKIIVSRKWGFTKFSRTDYLKYKSENRIVPDGVNAKLLGNHGPLAARQPGRAFLSSS
What are the official names of this protein?
60S ribosomal protein L10, EQM.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RLMKL_CELJU
Sequence: MIHQYFAACPKGLEGLLLQELQALGATDTRETIAGVYFNGDLNLAYRTCLWSRLANKILLPLANFEVNSQEDLYEGVRMLPWQDHLSPSGSLLVDFVGTNDAIRNTQFGALKVKDAIVDCLRDFSGVRPNIAKRDPDLLVNARLSKNKLVLSIDLSGESLHRRGYRLKQGSAPLKENLAAGILIRAGWPEVAAQGGALLDPMCGSGTFLVEAALMAADIAPGLGRASFGFERWLNHRNDLWLTLREEAHHRRKLGLAKVNLPEIRGYDADVRVVRAAEENIISAELDHWLRVSRKELAEFKKPTHRAMDYGLVLSNPPYGERLGEIESLKLLYAHLGERLRNEFPGWRAGVFTGNPELGKQMGLRADKKYKFFNGTIASELLMFSINTDVFVQSRVEQDGRFSKDEVERDAAEQKVKAAAKEEQAAALSNGAQMLVNRLQKNRKQLEKWARKNEVSCYRLYDADMPEYAAAIDLYLGQTPPNRAPQLYAHVQEYAAPKSVDEARAAQRFADIEAAVPYALDIPVSHISYKQRRRNKGSSQYEKLNERPTGDLFSVQEGQAKLHINLWQYLDTGLFLDHRPVRHMIANMARDKRFLNLFCYTATASVHAAMGGARYTVSVDMSNTYLNWARKNFALNGLSEARNRLEQADCLKWLENNDQQFDLILLDPPSFSNSKRMEDILDIQRDHVEMIHNAMRSLSEEGTLIFSNNLRNFKLDLEALGAYNIEDISARTIDEDFKRNPKIHQCWLIRH
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_AERHH
Sequence: MAKLSKRMRVIREKVDGTKEYSINEAIALLKELATAKFVESVDVAVNLGIDARKSDQNVRGATVLPHGTGREVRVAVFTQGANAEAAKAAGAELVGMDDLADLVKKGEMNFDVVIASPDAMRVVGQLGQILGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTLGKVSFNEVQLKENLEALLVALKKAKPSSAKGVFIKKVSISTTMGAGVAVDQASLEAQA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: MIAA_STAA2
Sequence: MNKNKPFIVVIVGPTASGKTELSIELAKRINGEIISGDSMQVYKHMNIGTAKVTPEEMDGIPHHLIDILNPDDTFSAYEFKRLAEDLITDITNRGKVPIIAGGTGLYIQSLIYNYELEDETVTPAQLSIVKQKLSALEHLDNQQLHDYLAQFDAVSAENIHPNNRQRVLRAIEYYLKTKKLLSNRKKVQQFTENYDTLLLGIEMSRKTLYSRINKRVDIMLDHGLFREVQQLVEQGYESCQSMQAIGYKELIPVINGQMIYEDAVNDLKQHSRQYAKRQMTWFKNKMSVHWLDKENMSLQMMLDEITTQIK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: PRRX1_CHICK
Sequence: MASSYAHAMERQALLPARLDGPAGLDNLQAKKNFSVSHLLDLEEAGDMVAAQGDEGGGEPGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLASKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSTTCTNASPAQGMNMANSIANLRLKAKEYSLQRNQVPTVN
What is the function of this protein?
May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face.
What are the official names of this protein?
Paired mesoderm homeobox protein 1, GMHOX, Homeobox protein MHOX, Paired-related homeobox protein 1, PRX-1.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DCUP_ACIAD
Sequence: MTALKNDRFLRALLREPVDTTPVWMMRQAGRYLPEYRETRAQAGDFLSLCKNTEFACEVTLQPLRRYDLDAAILFSDILTIPDALGLGLYFETGEGPKFKKTIRTEQDVLNLPNFNAKSDLDYVMNAVTTIHSALGGQVPLIGFSGSPWTLATYMVEGGSSKDFRYTKHMMYSQPEVLHALLDRLAVAVIDYLNAQIDAGAQAVQIFDSWGGALAHREYTEFSLNYMRKIVAGLQREKDGRRIPVILFTKGGGQWLEPMIATGADAIGLDWTTPLNVARKTVAGRVALQGNLDPAVLYGSAASIEKSVKAMLDDAYANGETTGYIANLGHGITQWVDPSQPKIFVDTVHEYSAKYLGS
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_LEIXX
Sequence: MPELPEVEVVRAGLAPAVTGATILGVEVFELRSLKRHDPLAGSFESLLTGRSMQTPARRGKFLWIPLDSSPRSAIVAHLGMSGQILLRDPGTVENGLLRIRLYIEHPEHGELWVHFVDQRLFGSMAVDALVPTVDGAPAGLGTDEALLPAQVSHIARDPLDPVFDDAAFAAVLARRRSGIKRVLLDQTLISGIGNIYADESLWAARIHYDHPATALSRPRVRTLLAELRRVLGRALAEGGTSFDAQYVNVNGASGYFSRSLHVYGRQGQPCDRCGTAIVRESFMNRGSHFCPRCQRM
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: KANK2_RAT
Sequence: MAQVLHVPAPFPGTPGQASSAAFPNKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVPVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRSGTNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAVLETRSVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRVVEGPREVEVAASTAAGAPAQRAQSLEPYGAGLKALATSAENTLVFRSHEVVETMCPLPTASTSNMHTAKKISITERNCTGAARMADPPPSPAEPSPSSPYPAAEPENPAPAAQDTTDRELTRPVASQDSQAAEGAGGASLGVQSALKRKEVPADPDVHQRNLQFVGINGGYESSSEDSSTAENSEHESTENEAPEPPVRVLSTAEGPQLRPLGPAVGKTSQDERQLSQESQRVPEAKVAPGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCQVDKLNRAGYSPIMLTALATLKTQDDIDTILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE
What is the function of this protein?
Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity).  Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity).  Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity).  Involved in the negative control of vitamin D receptor signaling pathway (By similarity).  Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity).  May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity).  Through the Rho signaling pathway may also regulate cell proliferation (By similarity).
What are the official names of this protein?
KN motif and ankyrin repeat domain-containing protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: PPK_SCHGR
Sequence: DGAETPGAAASLWFGPRV
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin, Capa-Pk, Scg-PVK-3.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPE_CROS5
Sequence: MPLTVRVITPDKTVWDGDVQEAILPSTSGQLGILAGHAPLLTALDTGVIRVRPDKEWKSIAVMGGFAEVELDEIKVLVNSAEAGDAIDKEAAKAEYDAAQSRLEEASKGGEPREQMKAANAYKRARARLQAAGGLV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: DNAJ_CHLL2
Sequence: MKKDYYEVLGVSRSASKDEIKKAYRKLALQYHPDKNPDNKDAEEHFKEVNEAYEVLSNDDKRRRYDQFGHAGVGSSAASGAGGAYAGGATDFNDIFSAFNDMFGGGRARGGGAPFGFEEVFGGGGGAGRRGRTSAGISGTDLKIRLKLTLEEIAKGVEKTLKIKKQIVCKECNGSGSKTGATEPCQTCHGSGEVRQASKTMFGQFVNITACPTCGGEGRVVKDRCTACYGEGIKQGDVTVKVTVPAGVQDGNYLTLRGQGNAGPRGGAPGDLIVVIEEKPHELFRRDGNDVIFNLALSYPDLVLGTKIDVPTLDGAVKLTIPPATQPESMLRIPGQGIGHLRGSGKGDQLVRVNVYVPKDLSHHEKELLKELKKTAAFSPSGSNNDKEEKSFFEKARDIFS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_AZOPC
Sequence: MRKAKPKKRQILSDAVFGSQRVTKFVNHLMYDGKKSMAFNIFYSALEKVRAKLSDEQKSSLEIWEHALNNITPLVEVKSRRVGGATFQVPTEIYPERKETISMKNMIFFARKRDGKSMADKLSAEIVDAFNSQGGAYKKKEDMRKMAEANRAFAYFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: LEXA_SHEFN
Sequence: MRPLTPRQAEILDLIKNNIAETGMPPTRAEIANRLGFKSANAAEEHLKALAKKGFIEIMPGTSRGIRLPQEEQVETGLPLIGQVAAGEPILAQEHVEQYYQVDPNMFKPAADFLLRVRGDSMKNIGILEGDLLAVHKMQQARNGQVVVARVDDDVTVKRFEQKGNVIYLHAENEDYNPIKVDLSCQSLTIEGLAVGVIRNGDWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: QDR2_YEAST
Sequence: MAGATSSIIRENDFEDELAESMQSYNRETADKLALTRTESVKPEPEITAPPHSRFSRSFKTVLIAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPKSYLNRAPILVLPTVRKSLHLDNPDYETLELPTQLNLLAPFKILKAYEICILMLVAGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRRLKYYQNWLGKKRSKLLEEHDNDLNLVQRIIENDPKYTFNIFKARLQPAFVTLLLSSSGFCAYGWCITVKAPLAAVLCMSGFASLFSNCILTFSTTLIVDLFPTKTSTATGCLNLFRCILSAVFIAALSKMVEKMKFGGVFTFLGALTSSSSILLFILLRKGKELAFKRKKQELGVN
What is the function of this protein?
Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate).  Implicated in potassium uptake.
What are the official names of this protein?
Quinidine resistance protein 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. CAR1 family.
Protein: RS7_VIBVU
Sequence: MPRRRVIGQRKILPDPKFKSELLAKFVNILMVDGKKSVAEKIVYTALDTMAEKSGKDHLAVFEEALENVRPAVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWLVEAARKRGEKSMAARLAAEMLDASDNKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.