PharMolix/UniProtQA huggingface dataset:
Protein: TR13B_HUMAN
Sequence: MSGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQVALVYSTLGLCLCAVLCCFLVAVACFLKKRGDPCSCQPRSRPRQSPAKSSQDHAMEAGSPVSTSPEPVETCSFCFPECRAPTQESAVTPGTPDPTCAGRWGCHTRTTVLQPCPHIPDSGLGIVCVPAQEGGPGA
What is the function of this protein?
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity.  Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1.  Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor.
What are the subcellular locations of this protein?
Membrane; Single-pass type III membrane protein.
Protein: CSTN2_RAT
Sequence: MLPGRLCLVPLLLALGVGSGGGSGDGGDSRRRRLLAAKVNKHKPWIETSYHGVITENNDTVILDPTIVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPQEAAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAIVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQRQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPGIHLETCDGAVSSLQVTAELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDGRQGAKIPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGACWQGGEVAKPRFAQFFHGSLASLTIRPGKMESQKVISCLQACKEGLDINSLESLGRGIKYHFNPSQSILVMEGDDIGNINQALQKVSYINSRQFPTAGVRRLRLSSKVQCFGEDVCISIPDVDAYIMVLQAIEPQITLQGTERFWRPAAQFESARGVTLFPDIKIISTFAKTEASGDLRATGTAPKSAVLEEMLHNLDFCDILVLGGDLDPRQECLELNHSELHQRHLDATNSTAGYSIYGVGSMSRYEQVLHHLRYRNWHPTSLETRRFQIKCSELNGRYTSNEFNLEVSVLHEVRVSDTEHVNHLIVQPPFLQSVYHPETRSSIQRSSVVPSIATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAKEAEMDWDDSALTITVNPMEKHEGPGHGEDETEGEEEEEAEEGMSSSSSGSDDSEEEEEEGMGRVRHGQSGTSSQRPERSTWNTAGVINIWK
What is the function of this protein?
Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity).  Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity).
What are the official names of this protein?
Calsyntenin-2.
What is the protein family that this protein belongs to?
Belongs to the calsyntenin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Golgi apparatus membrane. Postsynapse. Cell projection, dendrite. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.
Protein: UPPP_METKA
Sequence: MREIELWTAVLAGVVQGITEWLPISSEGQATMTMMKVLGIPPSTAMDLALWLHAGTLLAVLLRFGVPYWLTVRDLLMGGPWRRLGLFAIVATVCTAVVGLPVYKVLKGIFSAATGDAVQMAIGGALIVTGLLLRISPEGLRDRREVNVVDAVIVGLGQGFSVIPGISRSGTTMALLLWRRFDGGEAVWLSFYLAGPAMLGATALELKEGLSAATKMGTSWMVTAIGVSFVVSLICMEVLLRVARRLDFSKVCLLLGGIALLVPLAAKML
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
What are the official names of this protein?
Undecaprenyl-diphosphatase, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CWF17_SCHPO
Sequence: MDKRKESESATNGHLVKRIRIQDSSLITEGSVLQRTSDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTIFLGELN
What is the function of this protein?
Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
What are the official names of this protein?
Pre-mRNA-splicing factor cwf17, Complexed with cdc5 protein 17.
What are the subcellular locations of this protein?
Nucleus.
Protein: CP119_SULTO
Sequence: MYDWFKQMRKESPVYYDGKVWNLFKYEDCKMVLNDHKRFSSNLTGYNDKLEMLRSGKVFFDIPTRYTMLTSDPPLHDELRNLTADAFNPSNLPVDFVREVTVKLLSELDEEFDVIESFAIPLPILVISKMLGINPDVKKVKDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKGKEIVDLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAIEDFTLYNSWDYVREKGALKAVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDRTPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEIVKKEKIDNEVLNGYRKLVVRVERA
What are the official names of this protein?
Cytochrome P450 119.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_CHLAB
Sequence: MDRKGFLDSPSTKILQDLAVAPVDLTTPGIISQERVERFSLSIGGFTLSYATERVDEGVVSALTDLASERGLVSSMQAMQSGEVVNYIDNFPSESRPALHTATRAWVKEIPLTGNAEDIALRSKIEAQRLKDFLHQYRDAFTTIVQIGIGGSELGPKALHRALKGCCPSDKKVYFVSNIDPDNAAEVLQEIDCSKTLVVTVSKSGTTLETAVNEEFIADHFLKQGLHFRDHFIAVTCEGSPMDDRSKYLEVFHIWDSIGGRYSSTSMVGGVVLGFAYGFDVFFQLLEGAAAMDLAALAPQMSENLPMLAAMLGIWNRNFLGYPTSVIVPYSAGLEYFPAHLQQCGMESNGKSIAQTGEIIGFATSPILWGEVGTNSQHSFFQCLHQGSDVIPIEFIGFLDNQRGRDIVISGSTSSQKLFANMVAQSIALAKGRENTNPNKSFRGNRPSSLLVAERLTPYTMGALLAFYEHKIVFQGFCWGINSFDQEGVTLGKDLANQVLGIMQGQAKEGACLEAEALLKLFNSTQKKKS
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 066L_FRG3G
Sequence: MPFYICSDPDPKRTVRGPRFTVPDPKPPPDPAHPLDDTDNVMTAFPKFKPYGFSVYNPWDPIFLSMFGRAGRNGAKGPRGRRRSPRPPGGSSMTPGDDGNQGPRGPGEQRDQPDQMDPLVHPVTSVRSGPWERLGLRGRGESGVLRETLEMWAGQEGLISRVRDDPRESEVRPVTGVQTVWPE
What are the official names of this protein?
Uncharacterized protein 066L.
Protein: DNAK_PSESG
Sequence: MDRIIGIDLGTTNSCVSILENGNVKVIENAEGTRTTPSIIAYANDGEILVGQSAKRQAVTNPHNTLYAVKRLIGRKFEEDVVQKDIQMVPYKIVKADNGDAWVEVNGQKMAPPQISAEILKKMKKTAEDYLGEAVTEAVITVPAYFNDSQRQATKDAGRIASVDVKRIINEPTAAALAYGMDKAKGDHTVIVYDLGGGTFDVSVIEIAEVDGEHQFEVLATNGDTFLGGEDFDIRLIDYFVHEFKKESGMNLKGDPLAMQRLKEAAEKAKIELSSSTQTEVNLPYITADATGPKHLVVKISRSKLESLVEDLVQRTIAPCEMALKDAGIDRSKINDVILVGGQTRMPLVQKLVTEFFGKEARKDVNPDEAVAMGAAIQGAVLAGDVKDVLLLDVSPLTLGIEAMGGVMTALIKKTPRFLPRNPSVLTADDNQENAVAIHVLQGERKQAGQNKSLGKFDLAEIPPAPRGVPQIEVTFDIDANGILHVGAKDKATGKQQSIVIKANSGLSEEEIQQMVRDAEVNSEEDRKFEELASARNQGDALVHSTRKMIADAGDKVTAEQKTAVEAALVALEAAIKGDDKAAIEAKVEELSKVSAPIAQKMYAEQAENPEAAAKPAEENAKADDVVDAEFEEVKDHK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MIC60_TRIVH
Sequence: MLRNSIAPSRGLGSLARQRLTTSGRNLITKRSYIEGKSAAWPSGRSIASVLPARKTSCATFTTSATRGNEQNIRSPPSPSSASAISPEGISRPASSSPAGQTSPGSSVNPPEPPKAQTGAPPPPPPPPPAPKAKGRFGRSLLYLVLTAGVAYAGGVWFSLRSDNFHDFFTEYVPYGEEAVLYFEELDFRRRFPNATRHINTRPAAPRDEGEKVTIPSKSGVSWKVAENEGTSDVTHKGRHMSAVDAEVFRTGGDAKSASNKPTTEDKKGSEKTGSKKDESKERVPVTDTKKSTVSLDEPRKPAVATVSSIEPLAALQDDPIIQELTKIVNGLIAVINADESASKLAAPIAKAKDDFLKLGEQISSIKKEAHIAAQEEIKNAHKEFERSATELVRRIDEVRSEEAAEYREEFETEREKLANSYQEKIKTEVERANAVAEQRLRNELVEQAIQLNRKFLSDVDTLVEKERQGRFSKLSELSAQVAELEKLTAGWNEVIGANLTTQQLQVAVDAVHSALESESMPRPFINELLAVKSLAGQDPIVNAAISSINPTAYQRGIPSTAQIIDRFRRVANEVRKASLLPEDAGVASHATSYLMSKVMFKKEASSSGDDVESILTRTEKLLEQGNLDDAAREMNALRGWSKLLSKDWLADVRRVLEVRQALEVCFLFLLPTLSLLIYYNEY
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Plays a role in keeping cristae membranes connected to the inner boundary membrane.  Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
What are the official names of this protein?
MICOS complex subunit MIC60, Mitofilin.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic60 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: SYGB_TOLAT
Sequence: MATENFLIELGTEELPPKALRKLAQAFADNFTAELDKAGLAHQGVQWFAAPRRLALKVAALADKQADKQVEKRGPAVSAAFDAAGNPTPAAAGWAKSNGIEVAQADRLATDKGEWLVYRANVAGQPTTGLLPAMAATALAGLPIPKPMRWGAKRTQFIRPVHTLCMLFGAELVDGEILGLRSARIIRGHRFMGEAQFEISHADQYPALLLEKGKVQADYETRKAFIKAGAEAAAQQLGGIADIEESLLEEVTSLVEWPVILTATFEEKFLAVPAEALVHTMKGDQKYFPVYDNNGKLLPNFIFVSNIESKDPAQIIQGNERVVRPRLSDAEFFFNTDKKHSLASRLESLDTVLFQQQLGTLKDKSVRIAEMSAFIAAQIGADVEHATRAGLLSKCDLMTNMVMEFTDTQGVMGMHYARHDHEAEDVAVALNEQYMPRFAGDNLPNGLVACAVAIADKLDTLAGIFGIGQAPKGDKDPFALRRAAIGTLRIIVEKQLDLDLVDVVSKAAELYDGKISNKSVVDEVVDFMLGRFRASYQEAGIAVDVIQAVLARRPTRPADFDARVKAVSHFRTLDAAEALAAANKRVSNILAKFDGKLKDSVDAALLQDPAEQVLAQQVAAMETKLAPLFANGEYQLALTELAALREAVDTFFDKVMVMADDEALKLNRLTLLARLQALFLQAADISLLQQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTH_HYPNA
Sequence: MTTITLTPGSVPLSSWRALWQGATPKLDPACRPTIAGSASAVARILSRGKPVYGINTGFGKLAAVRIPDDQLEMLQRNIVLSHAAGVGEPSPANIVRLMMALKMTNLGRGASGVRLETIDLMEAMLAADLLPLIPAQGSVGASGDLAPLAHMACAMIGVGDVFLKGERLSAASAFRKAGLTPLPALAAKEGLALLNGTQFSTACALAGLFEAERILQSALVTGALSTEAAKGSDAPFDPRIHELRGHRGQIDCADILRDLMAGSAIRASHLENDTRVQDPYCIRCQPQVAGAALTLLRQAADTLLTESNGVSDNPLIFPETDEALSGGNFHAEPVAFAADMIAMALCEIGSISERRIAMLVDPALSGMPAFLTPQPGLNSGFMIPQVTAAALVSENKQMAFPASVDSIPTSANQEDHVSMAAHGARRLLTMAKNVDYILGIELLAAAQACDFHAPLRSSDALEALRARIRQDVPPLDHDRLMHPDIEAATGLIRSGEAIRAVNRPLPALEAAP
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_MARSD
Sequence: MASKLLLEIVTPDRKVLSQEVDYVGAPGIEGEFGIMANHIPFLSALGVGNLYFKEGNRTHYIFVSGGFAEVGNNKVTILAEVAEKAVEIDIARAQKAQEKAKARLAKAQDRIESARAQAALQRALARLTCKDAAQKAGTTTH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS12_METPB
Sequence: MPTINQLIAQPRKAQKARNKVPALNACPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHILRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: DNJC2_DANRE
Sequence: MLTEALEGQLTVVYNTVAASVQVQVEPVGRWFEAFLKRRNRNVSASFQELEEEEELSEEEEDEELQLEEYPMLKTLDPKDWKNQDHYAVLGLAHVRYKATQKQIKAAHKAMVLKHHPDKRKAAGEQIVEGDNDYFTCITKAIEILSDPVKRRAFDSVDPTFDNAVPTKAEGKENFFEVFAPVFERNARWSVKKHFPSLGTMESSFEDVDNFYSFWYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRASRAQRKKEEMNRIRTLVDTAYNADPRIKKFKEEEKARKESEKKAKVEAKKREQEEKERARQQQEEAARLLKEQQEEAARQAAQQAKKEKEAQKKAIKKERQKLRMTCKSQNYFTDNEADSVRMMEEVEKLCDRLELISLQTLNEALSAGNKEQSKAALEKQVQEVNMQLQKEKDAELQAQQAARGSEHSSAAGGQNNRGWSEEDLQLLIKAVNLFPAGTNARWEVIANYMNQHSSSGVRRTAKDVINKAKTLQKLDPHQKDEINRKAFEKFKKEHSAVPPTVDNAMPSERFDAVGADSNAAAWTTEEQKLLEQALKTYPVSTAERWERISEAVPGRSKKDCMKRYKELVEMIKAKKAAQEQVAAKNKK
What is the function of this protein?
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus.  When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.  When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity).
What are the official names of this protein?
DnaJ homolog subfamily C member 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: Y1911_STAAM
Sequence: MSFVTENPWLMVLTIFIINVCYVTFLTMRTILTLKGYRYIAASVSFLEVLVYIVGLGLVMSNLDHIQNIIAYAFGFSIGIIVGMKIEEKLALGYTVVNVTSAEYELDLPNELRNLGYGVTHYAAFGRDGSRMVMQILTPRKYERKLMDTIKNLDPKAFIIAYEPRNIHGGFWTKGIRRRKLKDYEPEELESVVEHEIQSK
What are the official names of this protein?
UPF0316 protein SAV1911.
What is the protein family that this protein belongs to?
Belongs to the UPF0316 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS8_CAMJD
Sequence: MINDIISDSLTRIRNAGMRKLETTKLLHSKAVEALVGIFQAKGYIESFNVIEEDKKKFINVVLKYDEKGKSVINNLKRISKPGRRVYKGKDEIKRFKNGYGTIVVSTSHGVLANDEAYKAGVGGEILCTIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RM19_SCHPO
Sequence: MASTRTTIIKLIVPAGKATPTPPIGPALGARGLKSIDFCKEFNARTAGWMPNTPVPCKITVTPQRTFTFTIHTPPTSWLISKTLDLEKGSSSPLHDIKGQLSLKHIYEIAKLKSTDPSLQGIELLSLCKSVIGTAKSMGVKVVP
What are the official names of this protein?
54S ribosomal protein L19, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: VPU_HV1MN
Sequence: MQPLVIAAIVALVVAGIIAIVVWSIVFIEYRKIRRQRKIDKLIDRISERAEDSGNESEGDQEELSALVGMGHDAPWVINDL
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: VL2_HPV67
Sequence: MRHKRSTRRKRASATQLYQTCKAAGTCPPDVIPKVERTTIADQILKFGSLGVFFGGLGIGTGSGTGGRTGYVPLSTRPPTASAPTSTIRPPVSVDTVGPLDSSIVSMIEETSFIESGAPAPSIPTASGFDVATSADNTPAIINVSSIGESSVQSVTTHLNPTFTEPSVLRPFSSSEASGHLIFSTPTISTHSYEDIPMDTFIVSTTSDNVTSSTPIPRPRPTARLGLYSKGTQQVKVVDPAFLTSPRRLITFDNPAFQPTEPDETLYFQHQDISPAPDPDFLDIVALHRPALTSRKGTIRFSRLGSKATMKTRSGKQIGARVHYYQDLSPIVPADSIELQPLSRPVSSASHSINDGLYDVYMDPDTPFPQPSISYSLHSPQTTNVTVPLSSGFDFPFSSTVPLQPGPDIVSPVAPTYTPFVPVIPTSPFNNVLVYGSDFILHPSYFLRRRRKRFPYFFADVRVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: RS19_STRGG
Sequence: MPRSLKKGPFVDGHLIKKVDVQNEAGTKNVIKTWSRRSMIVPAMLGHTIAVHNGKIHVPVFVTESMVGHKLGEFSPTRTFRGHVKDDRKSKRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: CYC_ORYSI
Sequence: MASFSEAPPGNPKAGEKIFKTKCAQCHTVDKGAGHKQGPNLNGLFGRQSGTTPGYSYSTANKNMAVIWEENTLYDYLLNPKKYIPGTKMVFPGLKKPQERADLISYLKEATS
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: RDRP_TMVOM
Sequence: MAYTQTATTSALLDTVRGNNSLVNDLAKRRLYDTAVEEFNARDRRPKVNFSKVISEEQTLIATRAYPEFQITFYNTQNAVHSLAGGLRSLELEYLMMQIPYGSLTYDIGGNFASHLFKGRAYVHCCMPNLDVRDIMRHEGQKDSIELYLSRLERGGKTVPNFQKEAFDRYAEIPEDAVCHNTFQTCEHQPMQQSGRVYAIALHSIYDIPADEFGAALLRKNVHTCYAAFHFSENLLLEDSYVNLDEINACFSRDGDKLTFSFASESTLNYCHSYSNILKYVCKTYFPASNREVYMKEFLVTRVNTWFCKFSRIDTFLLYKGVAHKSVDSEQFYTAMEDAWHYKKTLAMCNSERILLEDSSSVNYWFPKMRDMVIVPLFDISLETSKRTRKEVLVSKDFVFTVLNHIRTYQAKALTYANVLSFVESIRSRVIINGVTARSEWDVDKSLLQSLSMTFYLHTKLAVLKDDLLISKFSLGSKTVCQHVWDEISLAFGNAFPSVKERLLNRKLIRVAGDALEIRVPDLYVTFHDRLVTEYKASVDMPALDIRKKMEETEVMYNALSELSVLRESDKFDVDVFSQMCQSLEVDPMTAAKVIVAVMSNESGLTLTFERPTEANVALALQDQEKASEGALVVTSREVEEPSMKGSMARGELQLAGLAGDHPESSYSRNEEIESLEQFHMATADSLIRKQMSSIVYTGPIKVQQMKNFIDSLVASLSAAVSNLVKILKDTAAIDLETRQKFGVLDVASRKWLIKPTAKSHAWGVVETHARKYHVALLEYDEQGVVTCDDWRRVAVSSESVVYSDMAKLRTLRRLLRNGEPHVSSAKVVLVDGVPGCGKTKEILSRVNFDEDLILVPGKQAAEMIRRRANSSGIIVATKDNVKTVDSFMMNFGKSTRCQFKRLFIDEGLMLHTGCVNFLVAMSLCEIAYVYGDTQQIPYINRVSGFPYPAHFAKLEVDEVETRRTTLRCPADVTHYLNRRYEGFVMSTSSVKKSVSQEMVGGAAVINPISKPLHGKILTFTQSDKEALLSRGYSDVHTVHEVQGETYSDVSLVRLTPTPVSIIAGDSPHVLVALSRHTCSLKYYTVVMDPLVSIIRDLEKLSSYLLDMYKVDAGTQXQLQIDSVFKGSNLFVAAPKTGDISDMQFYYDKCLPGNSTMMNNFDAVTMRLTDISLNVKDCILDMSKSVAAPKDQIKPLTPMVRTAAEMPRQTGLLENLVAMIKRNFNAPELSGIIDIENTASLVVDKFFDSYLLKEKRKPNKNVSLFSRESLNRWLEKQEQVTIGQLADFDFVDLPAVDQYRHMIKAQPKQKLDTSIQTEYPALQTIVYHSKKINAIFGPLFSELTRQLLDSVDSSRFLFFTRKTPAQIEDFFGDLDSHVPMDVLELDISKYDKSQNEFHCAVEYEIWRRLGFEDFLGEVWKQGHRKTTLKDYTAGIKTCIWYQRKSGDVTTFIGNTVIIAACLASMLPMEKIIKGAFCGDDSLLYFPKGCEFPDVQHSANLMWNFEAKLFKKQYGYFCGRYVIHHDRGCIVYYDPLKLISKLGAKHIKDWEHLEEFRRSLCDVAVSLNNCAYYTQLDDAVREVHKTAPPGSFVYKSLVKFLSDKVLFRSLFIDGSSC
What is the function of this protein?
Is a methyltransferase active in RNA capping and an RNA helicase.  Methyltransferase displays a cytoplasmic capping enzyme activity.  This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus.  Helicase region probably exhibits NTPase and RNA unwinding activities (Potential).  It also acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  May mediate silencing suppression through either inhibition of HEN1-mediated siRNA or siRNA demethylation (By similarity).
What are the official names of this protein?
Replicase large subunit, 183 kDa protein, RNA-directed RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: GLRX1_VACCT
Sequence: MAEEFVQQRLANNKVTIFVKYTCPFCRNALDILNKFSFKRGAYEIVDIKEFKPENELRDYFEQITGGRTVPRIFFGKTSIGGYSDLLEIDNMDALGDILSSIGVLRTC
What is the function of this protein?
Has thioltransferase and dehydroascorbate reductase activities.
What are the official names of this protein?
Glutaredoxin-1.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: GPX4_HELAN
Sequence: MATQTVFDFPDDVLQQPPMPADNAFSDKDVKGQDVELSKYKGKVLLIVNVASQCGFTNSNYPELTTLYQKYKDQGFEILAFPCNQFGGQEPGSNEEIQVFACTRFKAEYPVFSKVNVNGKEADPLYKFLKSSKGGFLGDSIKWNFTKFLVDREGKVVDRYAPTTSPLSIEKDIKKLLNVA
What is the function of this protein?
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
What are the official names of this protein?
Probable phospholipid hydroperoxide glutathione peroxidase, PHGPx, Glutathione peroxidase 2.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIP7_ARATH
Sequence: MAYSKACYKLTTITILLLSFTLPSLAGNAENADVSECKAESGDLSCHNNKEAQKLKIIAIPSILVASMIGVSLPLFSRSIPALGPDREMSVIVKTLASGVILATGFMHVLPDSFDDLTSKCLPEDPWQKFPFATFITMISALLVLMIESFAMCAYARRTSKREGEVVPLENGSNSVDTQNDIQTLENGSSYVEKQEKVNEDKTSELLRNKVIAQILELGIVVHSVVIGLAMGASDNKCTVQSLIAALCFHQLFEGMGLGGSILQAQFKSKTNWTMVFFFSVTTPFGIVLGMAIQKIYDETSPTALIVVGVLNACSAGLLIYMALVNLLAHEFFGPKIQGNIKLHVLGYVATFTGAAGMSLMAKWA
What is the function of this protein?
Probably mediates zinc uptake from the rhizosphere.
What are the official names of this protein?
Zinc transporter 7, ZRT/IRT-like protein 7.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.