PharMolix/UniProtQA huggingface dataset:
Protein: SAMD8_MOUSE
Sequence: MPAGSRAGSRLRSGSLPRPSRLTLKALRPAYAPRTPDSNGDLDTGSELGPGSPAPTAEEVEKEMAGPSQLCIRRWTTKHVAVWLKDEGFFEYVDILCNKHRLDGITLLTLTEYDLRSPPLEIKVLGDIKRLMLSVRKLQKIHTDVLEEMGYNSDSPMSPMTPFLSALQSADWLCNGEPTHSCDGPIPDLSSDQYQYMNGKNKHSARRLDPEYWKTILSCVYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDSVPRIPWAFSMTEVCGVILCYIWILVLLLHKHRSILLRRLCSLMGTVFLLRCFTMFVTSLSVPGQHLQCTGKIYGSVWEKLRRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYHQSRRARIWFPMFSFFECNVNGTVPNEYCWPFSKPAIMKRLIG
What is the function of this protein?
sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide.  SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphatidylethanolamine (CPE) albeit with low product yield.  Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides.  Seems to be critical for the integrity of the early secretory pathway (By similarity).
What are the official names of this protein?
Sphingomyelin synthase-related protein 1, SMSr, Ceramide phosphoethanolamine synthase, CPE synthase, Sterile alpha motif domain-containing protein 8, SAM domain-containing protein 8.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelin synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: EX7L_MYCSK
Sequence: MTTPADDQGKSPENPWPVRAVATRVAKYIDRLGMVWIEGQLTELKIRQTTAWMVLRDPAADMSLSVSCPRDLVANAPVPLSEGTQVIVLGKPQFYTRNGSFSLRISEIRAVGIGELLARIDRLRRLLDAEGLFDPRLKRPIPFLPGTIGLITGRASHAERDVMTVAANRWPAVRFAVRNTIVQGPNAVPQIVGALRELDRDPGVDVIVLARGGGSVEDLLPFSDETLCREIASCTTPVVSAVGHEPDNPLCDLVADLRAATPTDAAKRVVPDAAAEQAFVTDLRRRSARALRQWVHREQHHLDQLRSRPVLARPLQAIDARADEVHRAVAAARRDVRRMVTVESERVGHLSARLTTLGPAATLARGYAVVQTMPDTNVLRTTADAPAGTHLRIRVADGAITAVSEGTDEAH
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AN_HHV6Z
Sequence: MDLNQISETLSAVAEEEPLTMFLLDKLYAIREKIKQVPFSIVRLCHVYCMLIKYNASNNNCILGRKLIEEMQQFLCGARVDGSEDVSMDMSELCKLYDYCPLLCSALCRAPCVFVNKLFKIVERETRGQSENPLWHALRRYTVTATKLYDIYTTRNFLEHKGQQFFGEAVIYGAKHERVIRHLVAIFYVKREVKETLGLLLDPSSGVFGASLDACFGISFNEDGFLMVKEKALIFEIKFRYKYLRDKEDHFVSELLKNPTEKSFSDFILSHPVPAIEFRERGKIPSSREYLMTYDFQYRPQRKLRTCPTPAILTPHIKQLLCLNETQTSTVIVFDCKSHLSEQKLSVFQKAVFTVNVFVNPKHRYFFQSLLQQYVMTQFYINDHSNPEYIESTEVPSVHIVTALFRRRTEEERSLHLVIDETEYIEEEIPLALIVTPVAPNPEFTCRVITDICNLWENNICKQTSLQVWAQSAVNQYLAACVRKPKTP
What is the function of this protein?
Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules.  Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate.  Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides.  Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.
What are the official names of this protein?
Alkaline nuclease.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae alkaline nuclease family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: TATB_HAEIN
Sequence: MFDIGFSELILLMVLGLVVLGPKRLPIAIRTVMDWVKTIRGLAANVQNELKQELKLQELQDSIKKAESLNLQALSPELSKTVEELKAQADKMKAELEDKAAQAGTTVEDQIKEIKSAAENAEKSQNAISVEEAAETLSEAERTPTDLTALETHEKVELNTHLSSYYPPDDIEIAPASKSQSSKTKS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ZDH17_DANRE
Sequence: MADALVGYEKEAGCVPILHPEEIKPQSHYNHGYNESRKSHVDDYSTWDIVKATQYGIFERCRELVEAGYDVRQPDKENVTLLHWAAINNRVDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCVHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEANANVDAQNIKGETPLDLAKQRKNVWMINHLQEARQAKGYDSPSYLKRLKMDKEFRQKVMLGTPFLVIWLVGFIADLDIDSWLIKGVMYAVMWLVVQFLSKSFFDHSMHSALPLGIYLATKFWMYITWFYWFWNDLPFVTIHLPFLLNSLALFYNFGKSWKSDPGIIKASEEQKKKTIVELAETGSLDLSIFCSTCLIRKPIRSKHCAVCNRCIAKFDHHCPWVGNCVGSGNHRYFMGYLFFLLCMICWMMYGCICYWRIHCATSYTKDGFWIYITQIATCSPWMFWMFLNSVFHFMWVAVLIMCQLYQIAVLGITTNERMNARRYKHFKVTATSIESPFNHGCMRNLIDFFELRCCGLLRPVPIDWTSQYTIEYDQTSGSGYQLV
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes.  Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).  Plays a role in axonogenesis (PubMed:26232532).
What are the official names of this protein?
Palmitoyltransferase ZDHHC17, Acyltransferase ZDHHC17, DHHC domain-containing cysteine-rich protein 17, Zinc finger DHHC domain-containing protein 17.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Presynaptic cell membrane; Multi-pass membrane protein.
Protein: SPT8_SCHPO
Sequence: MEAEESESFSYPMLLPSDGLYPEDDDDADMDQDKNPEENVMNEKEDEDVDAVDEKSGEEDVEMDTMEDENENDEDTEQTSEKKETEETPKENPLEKLKQKASTASFYDVVPTLAIPMATSINAFAFTSDLKWLFTGGEDGYIRKYDFFPSINGDLSLTVAQRHPFVDTVTKAGILLNYWENAYDGNKPSSVYSLAAHSRGLWVLSGVNNGDIILYSTRHQEGYPVTSLKKHTAPVSCLALHGSEKKVLSGSWDKMVYYWDLNTGDAISTYNCESGQISNIVYRPSGAVNPWGSESDDMRSLFGTPASSSSYDALFDEEVEKAIEEETKSVQANEENETEKPSQTESTTNNDNIKAPSESSSEESNIFLTTSIDGVMNVWDHRMVDSVLKYPVPKGVPPWAMSACWSPDGNNIYIGRRNGIVEEYNIHSGKEPVRSLKMPLDSGPVSNVYSMPNGRHLVISSFDNIRLYDLQSKAGIGFLIIPGHHGGLVSSLYVDTSCQFMFSASGNRGWQGTTTEVFLGYQIMTS
What is the function of this protein?
Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA.  SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes.  At the promoters, SAGA is required for recruitment of the basal transcription machinery (By similarity).
What are the official names of this protein?
Transcription factor spt8.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SPT8 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YR584_MIMIV
Sequence: MPKSSSNNPCPPGEILREGYYRHGYERRGFKRSSGTYIPPTEVSEAYVPPTCIIDRGKPGKGPRILPKPGNDLHLSWYGYAVHEPERDRHRALVEASQENDPLEVLRRLNLLRNYQAYPDVKDIMSQDVKFMSDFYAKYKERNQEANRFGRSNSRSRSNSRSKSSRSRSNNRSKSSRSSSTQSKSNNRSNSRSNSKTSRRLKKLPENDLDLDQDGGNRYGGDPLTSITSDTTGNQILETNIKLSKETECSEGKCQVFNKVYESHTINGKKIVFETLDQNDSENVLSLDKLYLDSDQTIDRVRQNLSTNKGYIIGIKSDNKLEGYCWYKEISNNEVKIFWFCANKGYGTALYTFMEKYFKLNNYSRIVIDVSMEGSYAVRRINFWNHQGFKTYQVKTDNHKIHMEKDI
What are the official names of this protein?
Uncharacterized N-acetyltransferase R584.
What are the subcellular locations of this protein?
Virion.
Protein: MUTS2_CLOB8
Sequence: MNERSLRILEFNKIKEKIKKYARTNAAKAKVEDLEPYDNLYEINNKLEETNEALEILISKGNPPLEGLADIHEGIERAKKGGTLSPGQLLKVGGMLKATRNMKEFFKREEVEKSYPKLEDLAYILAPVKALEDEIERAIVSEDEISDKASQTLCNIRRSLKEKNSSVREKISSIVRSNSKYLQDDLYTMRGDRYVLPVKSEYKSQVPGLVHDQSSTGATFFIEPMSLVNLNNEIRELFLKEKAEIERILSDLSLKVKINGDSCLSNLKVLVEFDFIFAKGRYASALNAIKPIVREDGAFSIFSGRHPLIENDKVVPSDIYLGEEFQTLMITGPNTGGKTVTIKTVGLLHIMGLSGLLIPARDNSSIAFFKEIFADIGDEQSIEQSLSTFSSHMTNIVNIMKHVDDKSLALFDELGAGTDPAEGAALAVSILETLRNRGAKLIATTHYSELKAYALKTDGVENASVEFDIETLRPTYRLLIGVPGKSNAFEISKRLGLVEGVIKRAKEYMSEENLQFENLIRELQEKSIIAKKEAREAKMLRDQAEDLKKKYEEKLEKLENTREKAYMDARREAKEIIANAKDEADDILKAMRELEKLGIAGGGRQRLEEERKKLKDSLEEREKGIHKMKENEGESITNVTLGMEAYLPSLNQKVIIVSMPDNRGEVQVEAGIMKVNVKLKDLRKTQVTKEEKVRRKREVKLNLSNVESRVDLRGLDAEEACYKADKYLDDAYMANLGEVTIVHGKGTGVLRKAINDMLKRHPHVKSYRLGAYGEGGDGVTMVELKG
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: RK32_CYACA
Sequence: MAVPKKRTSKSKKKSRRSHWINKAKTRIRNFLNLAKSISNKKATSFAYSTIKN
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YU309_USTMA
Sequence: MILQPSSSKSKLTSHQDHHLVPHSISLRRLLSRLDKSELVSLVTRWLDNAGPSYIPPMLSRRQPKAGQEDSVTNLTLYHAILDLNEERRCRSMDELRLLWTGPMSDPRVPKARALDRISDVDWPEGLSYAMVAELDLFYAHARQLSKTWSTVKLEYDDDVDAAGRGWERLSETQIRLRLGNELGHYFEHHIYLHPRVKPEDRNAAAVRSWTDSFSYFRIVLAPIPSDVCGTGLHILHLPRTPFLLVSGSLGRGSENREMALSAFAAAAGATTVNYAKPAAGSAAAKKLLAELNDAGEDAAGNRRTLGELRGKDPLALREILLHESGRLSSTSDASAAPAGVAGGGKARQMQFSQGGSGQGAEDGPLIAPLKRRREEDLSLLGIRPPTPPASGSERDTVSLSSASTSARPTQRRSSLTPCSQTPQETHQHAREALTTRMESQREANELFGPKPNPYDPSNDALPRVERIEYELHLPFPAMQRYNTRSLIDMDAYNSDPEKPKIKLRLEGTHVLAGLRKLVAAGMDRSTSRLDAGEGQGDDDDEEDGQAEKYEGAVKPVKLDGLPGWLTEVRGTKVVVQPSPPGDDSSRDM
What are the official names of this protein?
Putative uncharacterized protein UM10309.
Protein: MBI1_NEUCR
Sequence: MRLLKSHPLLKLVNSYLIDASQPSNISYLWNFGSLLACCLIIQIVTGVTLAMHYSPNVLEAFNSIEHIMRDVNNGWLVRYLHSNTASAFFFLVYLHIGRGMYYGSYRAPRTLVWAIGTVILILMMATAFLGYQHSPKWFDISNKGSISNKGNITNSLPPLLQRWGGRINKRLFNKNLVKRGYCTSSSLNSPEMSERLQTIINELGINPVYVYEDLNQPSSWKQILHDTRDLSGVYMIINKTTKDYYIGSASNNRFYTRFCNHVIHFTGSKIVKLAIKKYELKNFAFVILDLYPNVVTKENNKELLDLEDKYLKLLVPNYNILTEAGSSFGYKHTEIDRQKMKDLYSDARREKIGSLNRGKKFSPETIEKIREKALTRPPMSEETKIKCIANTRPVVLYNLNRTIYGKYSTILEAANAINCNEKTIRRALQTEKKLVKRQWIVEDFSDK
What is the function of this protein?
Mitochondrial DNA endonuclease involved in intron homing.
What are the official names of this protein?
Probable intron-encoded endonuclease bI1.
What is the protein family that this protein belongs to?
To endonucleases of group I introns of fungi and phage.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL31_RAT
Sequence: MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNLQTVNVDEN
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POLG_BSTVG
Sequence: ETEITPYGENEELLWRHRITTEVGDCGATMVALSDQKIVGFHSLGGISMNYFVPVTQELLDFLNSKTEKPLVPWRFSEDQVDVGGLYIHNDFDKFPFVKTIQKLVGFQNGHMIKYCGEGFTPVARSENRLSRQHVISGQRESFIHFVEASAKWRPIVTPMLGRLQPSALNREAYYKDVLKYDKPIRLGTVHEEAFQSAVINVIRILENAGFERGGVKACFDYGKIFNDLNLDAAMGALYAGKKKDYFVEATDEEIEEMFLRSAGKICANGHGVWSALLKAELRPAEKVAANKTRTFTSAPIDILFGAKAVVDDFNKQFYKRHLLGPWTVGINKFNKGWDLLARSLMRYEWFIDADGSQFDSSITPLLMNAVLTIRLYFMERDDITELMLRNLYTQIISTCMLAEDGLIVQKHRGNNSGQPSTVVDNTLCLMIAMEYARQRAISDGHLNMQMRYVCNGDDLLINANEEAKEVVQNKYEQYIKELELNYCFDDAFQSIEGVEFMSHKFMLRNGIYIPKLARHRIVAILEWQRSAEPQAIKSAILAACVEAFGYDDSTELIREYAISLEPVWGSFLPTDGEIEQLYLEGIAKQEVARCLAGVDDVCKFESAAPGTNEAVDEMLKAAGDDEALARANATSTSDTIPPARNVGADTTTPAKANPPSGRRPSSRSLIDNSIGGNGVQDVADRTSGIVFPVPTRKSTSLYLTPKVKLRATTEELRKYESTSLNPQQIDLRYSTQQELNDWIKASADGLGQTEEAFIDNILPGWIVHCIVNTTSSENRKAGSWRCVTNAGTADEEQVLYDIEPMYSAANPTMRAIMRHFSDLAGLVIAESFKQGRPLIPKGYIKAGVLDASSAARACDFVVRDRHDTATFVQVQNQVLVNRVSGITNWLFAQQCLALVLTRTWRAMTLRCRRGHPQPRLSASFLEVSTSCRARRRLGVQR
What is the function of this protein?
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae genome polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein]: Virion.
Protein: NUOK_BARQU
Sequence: MHIDITHYLIVSALIFTIGIAGIFLNRKNVIIILMSIELILLSVNLNFVAFSAFFQDLVGQIFALFILTVAAAEAAIGLAILVVFFRNCGSIAVEDVNVMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECA_CALS4
Sequence: MMIEKQKALEMAISQIERQFGKGAIMRLGDTAKLNVEVIPTGSLELDIALGVGGVPRGRIIEIFGPESSGKTTLALHMIAEAQKIGGTGAFIDAEHALDPVYAKNLGVNIDDLLVAQPDTGEQALEIAEALVRSGAVDIIVIDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLAGVTSKSKSIVVFINQLREKVGVMFGNPETTPGGRALKFYATIRLDVRKVDNIKQGNEIVGSRTRVKVVKNKIAPPFKQAEFDIMYGEGISREGSILDLGTALDIIEKSGSWYSYKDIKLGQGRENAKQFLKENKEIAEEIERKIRENFNLAYNKIKSAPDAIVE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_SHESW
Sequence: MTTDTIVAQATAPGRGGVGIIRISGDKATDVAMAVLGHLPKTRYADYCDFKNATGQVIDQGIALFFKGPNSFTGEDVLELQGHGGQIVLDMLIKRVLEVEGIRIAKPGEFSEQAFMNDKLDLTQAEAIADLIDATSEQAAKSALQSLQGEFSKEVHELVDQVTNLRLYVEAAIDFPDEEVDFLSDGKIANALYKIIDKLSTVQASAKQGSIIREGMKVVIAGRPNAGKSSLLNALAGKESAIVTEIAGTTRDVLREHIHLDGMPLHIIDTAGLRDTTDTVEQIGIERAWNEINSADRVLFMVDGTTTDAVDPHDIWPDFINRLPANLGVTVIRNKADLTGENLDMTEEKGYSVYRISAKTGLGVDELKLHLKSLMGYQSNLEGGFIARRRHLEALDVAASHLQLGKEQLEVYLAGELLAEELRMAQIALSEITGRFTSDDLLGKIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BBS12_XENLA
Sequence: MAIRGHKGLQQLLSMATSVNSFLGPMKSYKFIFDQITHESILTSSSFRLLENLDLTSAIGQLLNETIQAHHKSYKTGTTTLFFMVGAWSSAVQECLHLGIPVSLIVSVMLDGLNSCIGHVHSLQVSLVSQVTSDCTNIKTNGINHSNYSASGDQGNCSSELENNPLPRVSNMRTASEFPVAFHKKPLPLCTGTNLYKTQRRRLFHSRHLAEDLSFFQDVPERPQTTTLNNETLDGLAKGLAHGYQPVMNLVKNAVCLHCAEIKENSLDKSSFNISRLETCSLPGLSEEHTTVSFGYTTLVPTESAAVITHLNGKPLRILLVDGELTESHRHLGFDNPDNVKMVFEHAGNEKHNLEDSWISRAYEKIIQANINLILVRGDVCPFLLKQCIHRNILIVTQVKQNILQAFSECTGAEPVTYLTQINCCSVGNEAFVTLCTRANSIIEVSQKIVISITAKKLNLITATLSSRIPSTMQSIEDQFLTCAYRLHHALQEGNVFYGGGAIELLCIHHLQKLVQESSSSFYAYDNAQFHCLSSWMTESATFYRAAIIGCLAKGWYKYISVLLCNMGGFLSELDAVTFIENELQNISHHSSPIDYVRDQYSKKDLFNDEMGISISHHSLPVYDNVTPKLEAWRRALHLVLTVLQTDAEVITNSATQNQILMSETSNGEYLFL
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.
What are the official names of this protein?
Bardet-Biedl syndrome 12 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family. BBS12 subfamily.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: TWST1_NOMCO
Sequence: MMQDVSSSPVSPADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGGVGGGDEPGSPAQGKRGKKSAGCGGGGSAGGGGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERFSYAFSVWRMEGAWSMSASH
What is the function of this protein?
Acts as a transcriptional regulator.  Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction.  This interaction probably involves the basic domains of both proteins.  Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B.  Regulates cranial suture patterning and fusion.  Activates transcription as a heterodimer with E proteins.  Regulates gene expression differentially, depending on dimer composition.  Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression.  Heterodimerization is also required for osteoblast differentiation.  Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer (By similarity).
What are the official names of this protein?
Twist-related protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: COAE_MYCBO
Sequence: MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEGLASLVDAFGRDILLADGALDRQALAAKAFRDDESRGVLNGIVHPLVARRRSEIIAAVSGDAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQASDQQRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADPSWPDQARRIVNRLKIACGHKALRVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADELAEPLLAAGYPRLEHITQDTEKTDARSTVGRYDHTDSAALWHKRVHASADPGRPTNVHLRVHGWPNQQFALLFVDWLAANPGAREDYLTVKCDADRRADGELARYVTAKEPWFLDAYQRAWEWADAVHWRP
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UPF0157 (GrpB) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_CUPPJ
Sequence: MAYSFTEKKRIRKSFAKRATVHQVPFLLATQIESYTQFLQAETPAARRKTEGLQAAFNAIFPIASHNGLARMEFVSYHLSNPPFDVKECQQRGLTFHSALRAKVRLIINDRENPGKVKEVKEQEVYMGEIPLMTSTGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKSIGLTPEQILAHFFVFDNFTLQSEGAQLEFVPERLRGEVARFDIADKNGRVVVEKDKRINAKHIRDLDSAGTKLISVPEDYLLGRVLAKNIIDPDTGEVIANANDELTETVLENLREAGVKQIQTLYTNDLDQGPYMSQTLRVDETADQTAARIAIYRMMRPGEPPTEEAVEALFQRLFYSEESYDLSRVGRMKVNSRLSRPSGEGSMVLQDEDILETIKILVNLRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLSRVERAVKERLGQAETENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYARLNEYGFLETPYRKVENSKLTDQVDYLSAIEEGKYVVAQANATVDAEGNLTDELVSAREGSERETRMVTPDRVQYIDVAPSQIVSAAASLVPFLEHDDANRALMGANMQRQAVPCLRPDKPLVGTGIERTVAVDSGTAVQAMRGGVVDYVDAMRIVIRVNDDEAVAGEVGVDIYNLIKYTRSNQNTNINQRPMVKVGDIVARGDVVADGASTDLGELALGQNMLVAFMPWNGYNFEDSILISERVVAEDRYTSIHIEELSVVARDTKLGPEEITRDISNLAEAQLARLDESGITYIGAEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGIVIDVQVFTREGVTRDKRAQSIIDDELKRYRLDLNDQLRIVEGDAFQRLERLLIDKTVNGGPKKLAKGAKLTKEYLAEIDKYHWFDIRPADEEVAAQLEAVKEAIEQKRHEFDLAFEEKRKKLTQGDELPPGVIKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGTPADIVLNPLGVPSRMNVGQILETHLGWAARGLGQRIGDMLKASAKAQELRPLLAQIYNESGKAEDLDSLSDAEVLELATNLKKGVPFATPVFDGAHEDEIRRMLDLAYPDDIAKEKGLTASKQQVTLHDGRTGEAFERPVTLGVMHMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVNGRTKVYENIVKGEHSIDAGMPESFNVLVKEIRSLGIDIDLDRY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: STN1_HUMAN
Sequence: MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQVDVLGTVIGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARELSLTSQLKKLQETIEQKTKIEIGDTIRVRGSIRTYREEREIHATTYYKVDDPVWNIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLMENRVQSFYQQELEMVESLLSLANQPVIHSASSDQVNFKKDTTSKAIHSIFKNAIQLLQEKGLVFQKDDGFDNLYYVTREDKDLHRKIHRIIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSDIVSTMEHYYTAF
What is the function of this protein?
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation.  The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves.  In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
What are the official names of this protein?
CST complex subunit STN1, Oligonucleotide/oligosaccharide-binding fold-containing protein 1, Suppressor of cdc thirteen homolog.
What is the protein family that this protein belongs to?
Belongs to the STN1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: SYY_MESH2
Sequence: MSYIEKQEFLTELKTRNILKDISSPEKFFNLKPDQGIYIGFDPTATSLHLGNYISISLLKRLQKIGIKVLAVIGGATGMIGDPSFSSKERKLLDFKTLNANKEKIKKQLESFGLPVFDNFEIYKNMNILDFLRDVGKNINISYLLAKESVASRIEVGLSFTEFSYQLIQGWDFKFLAENYQIIGQAGGSDQWGNMVTGLDFIKKSNLVQKDEAFVFTTNLLTDENGQKFGKSLGKPIWLDPEMYSPFHLYQFLLNQNDEQAEKIMLWLSFLDLKVINELIFKHKNDKKQRILQYNLAQEVVFNIHGDKGLKIAKKITKILFEKLDYTEITFKDKLELKKIIPYFKVSFFNANQIIDLGIFKSKRELNEFISHKALEINGSKISNIGDITEELKDKSNLFLLRKGKKYFFIIELI
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR_KINRD
Sequence: MPHLLHLDSSADLATSRSRAVTAAFADTWRARGEEYTVTHRDLHRDPLPHFADAEQHWPAAARRPGANPPAEQDALTATLHAEVLAADVVLVGAPLYNYTVPSTLKVWLDHLHIPGVLAGEGSQPLAGRPAVVVSSRGATYDAGSPTEGWDHGVPVLRIVLGNSLGMDVHVVQTSATLADRLPEMAALKERGAAEFQAALAAARELARTL
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.