PharMolix/UniProtQA huggingface dataset:
Protein: GLYC_BRSVW
Sequence: MSNHTHHLKFKTLKRAWKASKYFIVGLSCLYKFNLKSLVQTALTTLAMITLTSLVITAIIYISVGNAKAKPTSKPTIQQTQQPQNHTSPFFTEHNYKSTHTSIQGTTLPQLPNTDTTRETTYSHSINETQDRKTKSQSTLPATRKPPINPSGSNPPENHQDHNNSQTLPHVPCSTCEGNPACSSLCQIGPERASSRAPTITLKKTPKPKTTKKPTKTTIHRKTSPEAKPQPKNNTAAPQQGILSSPEHHTNQPTTQIQQHTSI
What is the function of this protein?
Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
What are the official names of this protein?
Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG.
What is the protein family that this protein belongs to?
Belongs to the pneumoviruses glycoprotein G family.
What are the subcellular locations of this protein?
[Isoform Membrane-bound glycoprotein G]: Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Isoform Secreted glycoprotein G]: Secreted. Note=The protein is shed from infected cells before the appearance of progeny virus. The initiation at the downstream methionine removes a portion of the transmembrane domain. The remaining hydrophobic portion of the sG protein is essential for translocating it into the lumen of the ER during translation and would likely maintain its membrane association until a proteolytic event releases the mature sG protein into the medium.
Protein: YNG2_CANGA
Sequence: MDPSLLLDQMLQDVSNLPAEFRYMLEEVGLEDEQCLELRKRYQQKEGILHKYIKQNGSLAANPKEDELLAEVEQSMAQVRELQEEKCQRANTILFLVSRHLNKLQQNIIMLEEDGLLAPAEDEMESGPDFSRESSVVGSTVSERKRKAASEDHPRRKKQSRSMSNTHREKSYNKGDDTADVKSPASTEREGTLDLQNYQEELFSSMNDNEKEDQNLYCFCQRVSFGEMVACDGPNCKYEWFHYECVNLTEPPKGTWYCPDCKQEMSKKLKKKKQ
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair.  Involved in cell cycle progression and meiosis (By similarity).
What are the official names of this protein?
Chromatin modification-related protein YNG2, ING1 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the ING family.
What are the subcellular locations of this protein?
Nucleus.
Protein: M2_I57A2
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCNYRFFKHGLKRGASTEGVPESMREEYRKEQQSAVDTDDSHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: ADPRM_XENTR
Sequence: MESKRMEEPYFTFGIIADIQYADMDNRFNYLKTSMRYYRNSLTQLKAAVEEWAMESIKPAFILQLGDIIDGINTKDKSSKTALERVLVEMDKLPIQFHHVWGNHEFYNFSREYLNGSKLNSQARGDRIDRGGGTSENGEFNDESFYAYHFSPCPKFRFLLIDGYDLSPIGREKTSPKYDIALNLLKEKNPNEDLNSPTGLEEVQFVLFNGGISPSQLDWMERVLTSSDEKEENVFVVSHLPVHPDAADPMCLVWNYPEVLSVLQSHPCVVGYLAGHNHEGRYCMDPYGIHHLTFSGVIETPPESRAFGTMYVYEDKMVLKGRGLVEDRTLYYRDPKNKAERH
What is the function of this protein?
Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose.
What are the official names of this protein?
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase, ADPRibase-Mn, CDP-choline phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the ADPRibase-Mn family.
Protein: RLMN_NEIMB
Sequence: MKTNLLNYDLQGLTRHFADMGEKPFRAKQVMRWMHQSGAQNFDEMTDLAKSLRHKLNEQAGIEIPKLMMSQKSSDGTRKWLLDVGTGNGVETVFIPESDRGTLCISSQVGCALECTFCSTGRQGFNRNLTAAEIIGQLWWANKAMGVTPKNERVISNVVMMGMGEPMANFDNVVTALSIMLDDHGYGLSRRRVTVSTSGMVPQMDRLRDVMPVALAVSLHASNDEVRNQIVPLNKKYPLKELMAACQRYLVKAPRDFITFEYVMLDGINDKAQHARELIELVTDVPCKFNLIPFNPFPNSGYERSSNENIRVFRDILQQAGFVVTVRKTRGDDIDAACGQLAGQVQDKTRRQQKWQQILIGQQG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_CANAL
Sequence: MSQVAPKWYQSEDVPAPKQTRKTARPQKLRASLVPGTVLILLAGRFRGKRVVYLKNLEDNTLLVSGPFKVNGVPLRRVNARYVIATSTKVNVSGVDVSKFNVEYFAREKSSKSKKSEAEFFNESQPKKEIKAERVADQKSVDAALLSEIKKTPLLKQYLAASFSLKNGDRPHLLKF
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL6 family.
Protein: CTAA_EXIS2
Sequence: MNRKLSIFSAFVTFTMMIVLLMGGTVTKTDSGNGCGTDWPLCHGELIPTNPSVETMIEYSHRAVTGVVGLLIIALCLWTLVAFKDRLDIKIFAFLAFIFMLIQSIVGAGAVVWQQSDLVMALHFGISLISFASLLILTILIMERSGQEFRESVPAFLRKLLYGLLIYTLIVVYTGAFVRHVGATYACVGWPVCSQPTMTFEAWVQMIHRILAGLLFFYTLFVHYTAIRLKHRTSRTGMLFATFFISCQVATGAWIVLGGHATYVPLLHAFLITCYFGVISYLAYHAFRTRKKDSRLR
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HINT2_HUMAN
Sequence: MAAAVVLAAGLRAARRAVAATGVRGGQVRGAAGVTDGNEVAKAQQATPGGAAPTIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG
What is the function of this protein?
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367).  Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638).  Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367).  May be involved in steroid biosynthesis (PubMed:18653718).  May play a role in apoptosis (PubMed:16762638).
What are the official names of this protein?
Adenosine 5'-monophosphoramidase HINT2, HINT-3, HIT-17kDa, Histidine triad nucleotide-binding protein 2, mitochondrial, HINT-2, PKCI-1-related HIT protein.
What is the protein family that this protein belongs to?
Belongs to the HINT family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GCST_SYNS9
Sequence: MLRTPLYELCRTGGGRMVPFAGWEMPVQFSGLIQEHKAVRNSVGMFDISHMGVLRLEGANPKDTLQQLVPSDLHRIGPGEACYTVLLNDQGGIRDDLIIYDLGAIDEKRGALVLVINAACADSDTAWIRERMEPAGLTVTDIKNNGVLLALQGPQAIPLLEQLSGEDLSGLPRFGHRDLQIQGLSNSVFTARTGYTGEDGAELLLTAEDGQLLWSQLLEKGVAPCGLGARDTLRLEAAMHLYGQDMNADTNPFEAGLGWLVHLEMPADFIGRQALERAAETGPNKRLVGLKLEGRAIARHDYPVLHNGEPVGVVTSGTWSPTLEEPIALASIPTALAKLGTNLSVEIRGKAQPATVVRRPFYKRP
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: ODRB1_ODOHA
Sequence: MFTTKKPLLLLFFLGIISLSVCEQERDADEEDGGEVTEEEVKRAALKGCWTKSIPPKPCFGKR
What are the official names of this protein?
Odorranain-B1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LYSY_NITMS
Sequence: MKVGVVGASGYVGGETLRLLVNHPNVEITMVTSRQHVGEYLHRVQPSLKGFTDLTFSELDYDKLTDKCDLVFTAVPHGTATEIVKALYDRGIKIIDLSADYRLHDQDAYDKWYGWEHPHPDYLNKSVFGVPELHREEIKKAQLVSCPGCMAVTSMLALAPLIRNNIIDTDHIVVDSKIGSSGAGSGSGTAHAMRAGVIRPYKPAKHRHTGEIEQELSEIAGKKIHVSMSPHAVDVVRGILCTNHTFMQKDMEEKELWKLYRQTYGEEKFVRLIRDKKGLYKFPDPKFLVGSNFCDIGFDLDEDNNRLIALSASDNLMKGAAGSAIQNMNVMCGFDEMDGLRYTPLTPV
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.
What are the official names of this protein?
Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_METSK
Sequence: MRDSVIDIRGLDRVQRARVQAKEEAPKRWSVDDIVALFELPFSDLMHRAQSVHRENFDPNGVQVSTLLSIKTGGCSEDCGYCPQAARYHTDVEKQDLHAAGRGTRSRVLPRRMRQPFCMAAWQPKQRDLEPVLAMIREVKAMGLETCATLGMLKDGQAEQLKEAGLDYYNHNLDTAPEYYGEVITTRTYQDRLDTLDRVREQDINVCCGGIIGMGESRVQRAGLLAQLANMERPPESVPDQLLTQVEGTPMYGMDELDPFEFVRTIAAARITMPQSFVRLSVGRQSMHEGIQALCFLAGANSIFYGEKLLTTGNPEAEADRKLFDKLGIHPL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RPOB_LACDB
Sequence: MLNGHVVNYGQHRTRRSFSRIKEILPLPNLTDVQTESYKWFLDEGVKEVFDDILPISDTSGRLTLEYVDYKLQEPKYTVDESRKHDATYSAPMHVTLKLTNHETGEIKTQDVFFGDLPLMTKSGSFIVNGAERVIVSQLVRSPGVYYSGEFDKNGRQIFGTTVIPNRGAWLEFETDAKNISYVRVDRTRKLPLSVLVRALGFGSDSEIKEIFGDSDTLDLTLDKDVHKNPADSRVAEALKDIYDRLRPGEPKTTDSSRSLLVSRFFDPRRYDLAAVGRYKVNKKLSLKNRLLGYTLAETLADPDTGEVLAAKGTVVNNEVMDVLKDYLDRDDFKTVTYTPSDEGVIPEPVTVQEIKVFSREIPDREIKLISNGHIAEDVKCITPADIIASVNYFLELQEGVGNIDDIDHLGNRRIRRVGELLQNQMRIGLARMERVVRERMSIQDAATVTPQQLINIRPIVGSIKEFFGSSQLSQFMDQNNPLGELTHKRRMSALGPGGLSRDRAGYEVRDVHYTHYGRLCPIETPEGPNIGLINSMATYAIINKYGFLETPYRRVSWATHKVTDKIDYLTADEEDNYIIAGANTPLNEDGSFVDDVILCRHREDNVEVSPDRIDYIDVIPKQVVSVTSACIPFLENDDSNRALMGANHQRQAVPLINPHGPLVATGMEYRAGHDSGDALLAEADGEVEYVDANEIRVRREDQTLDTYTLEKYRRSNATKNYNQTPNVKRGDKVVDGQVIANGPSMADGELALGQNPVIAFTTWNMYNFEDAIMLSERLVKEDVYTSIHIEDYDSEARDTKLGPEEITREIPNVGEDALKDLDENGIIRIGAEVHDGDILVGKVTPKGITELSAEERLLHAIFGEKAREVRDTSLRVPHGGGGVVQDVQVFTREAGDELAPGVNTLVRVYIVQKRKIQVGDKMSGRHGNKGTVALIAPVEDMPYLPDGTPVDICLNPMGVPSRMNIGQLLEIHLGRAARALGIHVATPVFDGASEDDVWDFVREAGVDSDGKTVLYDGRTGEPFHNRVSVGVMYYLKLTHMVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTYKSDDVVGRVKAYEAIVKGERITKPGVPESFRVLVKELQSLGLDLRVLDSDENEVELRDMDEDSNEHVNIDALSRLAEAQEKKKLAEEEAEIAAEAEAEGSAEEDAAEADADANEAETADDDKASK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PURL_SINMW
Sequence: MTISNTRPITPDLIASHGLKPDEYERILNLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGVVDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGSPDHPKTRHLVSGVVAGVGGYGNSFGVPTVGGEVEFDARYNGNILVNAFAAGLAKTDAIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTVQVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMTAYEMMLSESQERMLMVLRPEKEEEAKAIFVKWGLDFAIVGKTTDDLRFRILHQGEEVANLPIKELGDEAPEYDRPWTPAKVPSPLATNDIPQADVADTLLQLVGSANNSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVEGHEAKALAFSSDVTPRYVEADPFEGGKQAVAECWRNLTATGALPLAATDNLNFGNPERPEIMSQLVHAIKGIGEACQALDFPIVSGNVSLYNETNGQAILPTPTIGGVGLVRDWSKMARIRFAVADETILLAGAPKSWGTHIGQSVYMRDIHGRTDGPAPHVDLAHERKVGDFVRGLIGDGLVTAVHDCSSGGLALAVAEMAMASGIGATIAAPAEHDAIPVFYGEDQGRYVVTVANGAVETVAARAKAAGVALPVIGRTGGDAVKLGDARPVSVNALRSAHEAWFPNYMGGDLAPDN
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3408_LACPL
Sequence: MVEIKVIHGDITKMTVDAIVNAANTSLLGGGGVDGAIHRAAGPALLAACRPLHGCATGEAKITPGFRLPAKYVIHTPGPVWQGGQHNELQLLANSYRNSLNLAAENHCQTVAFPSISTGVYHFPLSIAAPLALKTLQATAQTTAHTVQTITIVCFDDQTQNVFSTALAALTN
What are the official names of this protein?
Macro domain-containing protein lp_3408.
Protein: DHQS_METAC
Sequence: MKKKSVWIKADEGGWEEQKDRITTGLESGADCVLVNPGDVEKVRELGNITVAAFARDNKSRADIVVVGKRGEGDGTKPLPQEIPGSFDINAATLLMDKGVTVGGYVVIKDKHYEHFAAEMGKICDYLLVTGTDWKVIPLENLIADLQHQKVKIIFGVKSAEEARLAFQTLEAGADGVLLDSGNPQEIKDTIKAARELESESAELEAAVVTRVEPLGMGDRVCVDTCNLMQRGEGMLIGSQASGMFLVNSESDDSPYVAARPFRVNAGAVHSYIKIGEKTRYLSELRAGDPVTIVDSKGKQREGIVGRVKIESRPLMLIEAKARDRTLTAILQNAETIKLVGKDGTPISVAKLEKGDEVLVRLEEGARHFGKKIEETIIEK
What is the function of this protein?
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
What are the official names of this protein?
3-dehydroquinate synthase, DHQ synthase, 3-dehydroquinate synthase II.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type DHQ synthase family.
Protein: POTA_MYCGE
Sequence: MNEHSLIEIEGLNKTFDDGYVSIRDISLNIKKGEFITILGPSGCGKTTLLRLLAGFEDPTYGKIKVNGIDIKDMAIHKRPFATVFQDYALFSHLTVYKNIAYGLKVMWTKLDEIPKLVSDYQKQLALKHLKLERKIEQLQKNNSNAQRIKKLKEKLQKLLEINKQKVIEFENKEKLRREDIYKNLEQLTKEWDLLSQKKLKEVEQQKQAIDKSFEKVENKYKKDPWFFQHSEIRLKQYQKKKTELKADIKATKNKEQIQKLTKELQTLKQKYANKKAIDKEYDKLVVAYNKKDYWTSYWETYTLQQKEAFEKRYLSRKLTKAEQNKKVSDVIEMVGLKGKEDRLPDELSGGMKQRVALARSLVVEPEILLLDEPLSALDAKVRKNLQKELQQIHKKSGLTFILVTHDQEEALVLSDRIVVMNEGNILQVGNPVDIYDSPKTEWIANFIGQANIFKGTYLGEKKIQLQSGEIIQTDVDNNYVVGKQYKILIRPEDFDLVPENKGFFNVRVIDKNYKGLLWKITTQLKDNTIVDLESVNEVDVNKTFGVLFDPIDVHLMEV
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LIMA1_HUMAN
Sequence: MESSPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEETNMEKKRSNTENLSQHFRKGTLTVLKKKWENPGLGAESHTDSLRNSSTEIRHRADHPPAEVTSHAASGAKADQEEQIHPRSRLRSPPEALVQGRYPHIKDGEDLKDHSTESKKMENCLGESRHEVEKSEISENTDASGKIEKYNVPLNRLKMMFEKGEPTQTKILRAQSRSASGRKISENSYSLDDLEIGPGQLSSSTFDSEKNESRRNLELPRLSETSIKDRMAKYQAAVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAEDDSRDSQVKSEVQQPVHPKPLSPDSRASSLSESSPPKAMKKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKNENEEILERPAQLANARETPHSPGVEDAPIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSRPFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQVENAKASKKNGNVGKTTWQNKESKGETGKRSKEGHSLEMENENLVENGADSDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAEEFTTQNQKSQDVELWEGEVVKELSVEEQIKRNRYYDEDEDEE
What is the function of this protein?
Actin-binding protein involved in actin cytoskeleton regulation and dynamics.  Increases the number and size of actin stress fibers and inhibits membrane ruffling.  Inhibits actin filament depolymerization.  Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430).  Plays a role in cholesterol homeostasis.  Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption.  May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity).
What are the official names of this protein?
LIM domain and actin-binding protein 1, Epithelial protein lost in neoplasm.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell membrane. Note=Expressed in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (PubMed:24694988). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity).
Protein: GLPK_CORGB
Sequence: MRISKANAYVAAIDQGTTSTRCIFIDAQGKVVSSASKEHRQIFPQQGWVEHDPEEIWDNIRSVVSQAMVSIDITPHEVASLGVTNQRETTVVWDKHTGEPVYNAIVWQDTRTSDICLEIAGEEGQEKWLDRTGLLINSYPSGPKIKWILDNVEGARERAEKGDLLFGTMDTWVLWNLTGGVRGDDGDDAIHVTDVTNASRTLLMDLRTQQWDPELCEALDIPMSMLPEIRPSVGEFRSVRHRGTLADVPITGVLGDQQAALFGQGGFHEGAAKNTYGTGLFLLMNTGTSLKISEHGLLSTIAYQREGSAPVYALEGSVSMGGSLVQWLRDNLQLIPNAPAIENLAREVEDNGGVHVVPAFTGLFAPRWRPDARGVITGLTRFANRKHIARAVLEANAFQTREVVDAMAKDAGKALESLRVDGAMVENDLLMQMQADFLGIDVQRLEDVETTAVGVAFAAGLGSGFFKTTDEIEKLIAVKKVWNPDMSEEERERRYAEWNRAVEHSYDQA
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: GLPK_RALSO
Sequence: MEYLLALDQGTSSSRAIVFNRAGQIVASAQQEFPQHFPQPGWVEHDPLDIWSSQLATCRAALEQARLGAADMAALGITNQRETTVVWERATGRPIFNAIVWQDRRTEAICERLRAEGLEDEVRKRTGLVIDPYFSGTKLRWILDHVDGARERAARGELAFGTIDSWLVWQLTRGRLHVTDVSNASRTLLWNIHTGQWDADLMRALDIHPSLLPEVHPSAHRFGQTDADWLGAPLTIGGIAGDQQSALFGQACFKPGMAKNTYGTGCFMLLNTGERAVESRNGLISTAACQSGSRRSYALEGSVFVGGAVVQWLRDGLRAIQRSADVEGLAASVPDSGGVVFVPSFTGLGAPYWDPTAQGAIVGLSRGTTIGHIARAALESIAFQSTALLQAMTRDAVSAITELRVDGGASANNLLLQFQADLLGIPVVRPEIIETTALGAAYLAGIATGFYRSEDEVARQWRASRTFHPVISRDEAQHRMAQWEMAVAQVRLPTTHGH
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RIMM_METRJ
Sequence: MARRPAGPTSRDGGRRGRTSSAIGKIAPDAATSPKAPAPRPAPPPVPPDPNLVLLGEFGRAHGLTGEVRLKSYTGDPQAIAGYGALQTSDGRTLALADVRPAPGSSPDMLIARVKGVSGRSAAEALNRVALFVPRDRLAAPEDDDEVYAADLIGAAAVDEAGTLVGTIVAVPNYGGGDLLELRPPNGGATALLPFTKAFVPVLDVAQRRVTVAAPEDLFAAPGEKPADDPG
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTB_PSEA7
Sequence: MNAHEVNFDGLVGPTHNYGGLSYGNVASQSNSQALSNPKEAAKQGLAKMKALMELGFKQGVLAPQARPDTAALRSLGFSGSDEEVIRRAAKEAMPLLAACSSASSMWTANAATVSPSADTADGRVHFTAANLNCKFHRSIEHPTTSRVLAAMFNDERHFAHHAALPAVSQFGDEGAANHTRFCKDYGDAGVEFFVFGRSAFDSRFPAPQRYPARQTLEACQAVARLHGLSEAGVVYAQQNPAVIDQGVFHNDVISVGNGEVLFHHEDAFLDTEKVLAELHDKLGRRGGRFRAICVPREQVAVEDAVKSYLFNSQLLSKADGSMLLVVPEECRNNPRVWNYLERLTGDDGPIREVKVFDLKQSMQNGGGPACLRLRVALKEQELAAVNPGVIMTAGLYDTLVAWVDRHYRDRLGEADLADPQLLQECRTALDELTQILKLGSVYSFQLD
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: ESTD_HUMAN
Sequence: MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQNFISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVLCPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA
What is the function of this protein?
Serine hydrolase involved in the detoxification of formaldehyde.
What are the official names of this protein?
S-formylglutathione hydrolase, FGH, Esterase D, Methylumbelliferyl-acetate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle.