PharMolix/UniProtQA huggingface dataset:
Protein: ACV1B_MOUSE
Sequence: MAESAGASSFFPLVVLLLAGSGGSGPRGIQALLCACTSCLQTNYTCETDGACMVSIFNLDGVEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYIDFCNKIDLRVPSGHLKEPAHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
What is the function of this protein?
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B).  Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.  Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.  Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals.  Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase.  The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B.  Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail.  Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4.  This SMAD complex translocates into the nucleus where it mediates activin-induced transcription.  Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.  Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.  ACVR1B also phosphorylates TDP2.
What are the official names of this protein?
Activin receptor type-1B, Activin receptor type IB, ACTR-IB, Activin receptor-like kinase 4, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SYM_SALTY
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSDENRELSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSADQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTTSFDEYWKKDSDAELYHFIGKDIVYFHSLFWPAMLEGSHFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLKHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLAAELADPQLYKTFTDAAAVIGEAWESREFGKAIREIMALADIANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPTLSERVEAFLNSELNWDAIEQPLLGHKVNTFKALYNRIDMKQVEALVESSKEEVKAAAAPVTGPLADFPIQETITFDDFAKIDLRVALIENAEFVDGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRQTVMVANLAPRKMRFGVSEGMVMAAGPGGKDIFLLSPDDGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRS9_ARATH
Sequence: MAIIAVAELVEEVSMSRVEHVLNYLKRRQLENPGFLYAIEDDCGNVFWADPTCRLNYTYFGDTLVFDTTYRRGKRYQVPFAAFTGFNHHGQPVLFGCALILNESESSFAWLFQTWLQAMSAPPPPSITVEPDRLIQVAVSRVFSQTRLRFSQPLIFEETEEKLAHVFQAHPTFESEFINCVTETETAAEFEASWDSIVRRYYMEDNDWLQSIYNARQQWVRVFIRDTFYGELSTNEGSSILNSFFQGFVDASTTMQMLIKQYEKAIDSWREKELKADYEATNSTPVMKTPSPMEKQAASLYTRAAFIKFQEEFVETLAIPANIISDSGTHTTYRVAKFGEVHKGHTVSFDSLEVKANCSCQMFEYSGIICRHILAVFSAKNVLALPSRYLLRRWTKEAKIRGTEEQPEFSNGCQESLNLCFNSLRQEATKYVEEGAKSIQIYKVAMDALDEAAKKVAAASNRTPGTRLPNGEAYPSEEARETANATNHPGGEKERTILELTAELERTGQRCEVYRANLLSILRDMEEQKFQLSLKVQNARLSLKE
What is the function of this protein?
Putative transcription activator involved in regulating light control of development.  May act as a negative regulator specific to phyB signaling.
What are the official names of this protein?
Protein FAR1-RELATED SEQUENCE 9.
What is the protein family that this protein belongs to?
Belongs to the FHY3/FAR1 family.
What are the subcellular locations of this protein?
Nucleus. Note=The nuclear localization is independent of the light treatment.
Protein: AKR1_SOYBN
Sequence: MTQAQIQPVKLGTQGFEVSKLGFGCMGLTGAYNDPLQEQDGISVIKYAFSKGITFFDTADVYGANANELLVGKALKQLPREKIQIATKFGIASRGFPDMKIEGSPEYVRSCCETGLKRLDVEYIDLYYQHRVDTSVPIEETVGELKKLVEEGKVKYIGLSEASPDTIRRAHAIHPITAVQIEWSLWTRDIEEEIVPLCRELGIGIVPYSPLGRGFFGGKGVVENVPTNSSLKAHPRFQAENLDKNKNIYERIEGLAKKHQATPAQLALAWVLQQGEDVVPIPGTTKIKNLDQNIGALAVKLSEKDLREIFEAVPIGDVAGGRYYNGLDHFSWKYANTPPKDSKIST
What is the function of this protein?
May interfere with the nodulation process and inhibits nodule development.
What are the official names of this protein?
Probable aldo-keto reductase 1, GmAKR1.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase 13 family.
Protein: PLD_STRCW
Sequence: MTSRYRSSEAHQGLASFSPRRRTVVKAAAATAVLAGPLAAALPARATTGTPAFLHGVASGDPLPDGVLLWTRVTPTADATPGSGLGPDTEVGWTVATDKAFTNVVAKGSTTATAASDHTVKADIRGLAPATDHWFRFSAGGTDSPAGRARTAPAADAAVAGLRFGVVSCANWEAGYFAAYRHLAARGDLDAWLHLGDYIYEYGAGEYGTRGTSVRSHAPAHEILTLADYRVRHGRYKTDPDLQALHAAAPVVAIWDDHEIANDTWSGGAENHTEGVEGAWAARQAAAKQAYFEWMPVRPAIAGTTYRRLRFGKLADLSLLDLRSFRAQQVSLGDGDVDDPDRTLTGRAQLDWLKAGLKSSDTTWRLVGNSVMIAPFAIGSLSAELLKPLAKLLGLPQEGLAVNTDQWDGYTDDRRELLAHLRSNAIRNTVFLTGDIHMAWANDVPVNAGTYPLSASAATEFVVTSVTSDNLDDLVKVPEGTVSALASPVIRAANRHVHWVDTDRHGYGVLDITAERAQMDYYVLSDRTQAGATASWSRSYRTRSGTQRVERTYDPE
What is the function of this protein?
Catalyzes the hydrolysis of the ester bond between the phosphatidic acid and alcohol moieties of phospholipids.  Can catalyze a transphosphatidylation reaction in the presence of high concentrations of primary alcohols.  Has also phosphatase activity toward p-nitrophenyl phosphate.
What are the official names of this protein?
Phospholipase D, PLD.
What is the protein family that this protein belongs to?
Belongs to the PhoD family.
What are the subcellular locations of this protein?
Secreted.
Protein: RRAB_ALIFM
Sequence: MSQEDEYLSVEQFLELQKAETREIIESLKADGSEPDALYAIEHHLMAEDFKALENAVVEAFKMGFEVLEAEELEDEDGAKILCCDAVMDSALDAEVIDAQVEKLVNLAEKYDIIYDGWGTYYEGEDAEYDVIEDGDED
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity B.
What is the protein family that this protein belongs to?
Belongs to the RraB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUP_MYCUA
Sequence: MAQEQTKRGGGGGDDEDVTGTTAAGQERRKKLAQDTDDLLDEIDDVLEENAEDFVRAYVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: CODY_STAA8
Sequence: MSLLSKTRELNTLLQKHKGIAVDFKDVAQTISSVTVTNVFIVSRRGKILGSSLNELLKSQRIIQMLEERHIPSEYTERLMEVKQTESNIDIDNVLTVFPPENRELFIDSRTTIFPILGGGERLGTLVLGRVHDDFNENDLVLGEYAATVIGMEILREKHSEVEKEARDKAAITMAINSLSYSEKEAIEHIFEELGGTEGLLIASKVADRVGITRSVIVNALRKLESAGVIESRSLGMKGTFIKVKKEKFLDELEKSK
What is the function of this protein?
In S. aureus, targets include over 200 genes (PubMed:20363936, PubMed:27116338).  Acts mainly as a repressor of genes involved in amino acid transport and metabolism, including the branched-chain amino acids (BCAAs) biosynthetic operon (PubMed:19251851, PubMed:20363936, PubMed:27116338, PubMed:29357354).  Several genes involved in nucleotide synthesis and transport are activated (PubMed:19251851).  Binds to a 21-bp conserved DNA motif, the CodY-binding site (PubMed:20363936).  Additionally, in pathogenic bacteria, CodY also regulates virulence gene expression and provides a regulatory link between metabolism and pathogenesis (PubMed:18156263, PubMed:19251851, PubMed:20363936, PubMed:27116338, PubMed:29378891).  Genes encoding virulence and defense factors are either up- or down-regulated by CodY (PubMed:19251851).  Among others, is involved in the repression of the accessory gene regulator (agr), the hemolytic alpha-toxin (hla) gene, and the icaADBC operon, responsible for the production of polysaccharide intercellular adhesin (PIA), a major contributor to biofilm formation in S. aureus (PubMed:18156263, PubMed:19251851).  Also regulates the expression of thermonuclease (nuc) via the Sae two-component system, by binding directly to the sae P1 promoter region and blocking the binding of the positive regulator SaeR (PubMed:27116338, PubMed:29378891).  It restrains Sae-dependent production of leukocidins (PubMed:29378891).  CodY also controls the sae locus indirectly through Agr and Rot-mediated repression of the sae P1 promoter (PubMed:29378891).  The virulence genes regulated by CodY fall into three groups: one group is regulated directly by CodY, a second group is indirectly regulated by CodY, in particular through its repression of the agr and sae loci, and a third group is regulated in two ways, by direct repression and by repression via another regulator (PubMed:19251851, PubMed:20363936, PubMed:29378891).  S. aureus may use CodY to limit host damage to only the most severe starvation conditions (PubMed:27116338).  Modulation of central metabolism, virulence gene expression, and biofilm-associated genes to optimize growth on preferred carbon sources until starvation sets in may require coordinated action of CodY and the carbon catabolite protein A (CcpA), another global transcriptional regulator (PubMed:35735992).
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COA8_RAT
Sequence: MAALRPGSKALRRLLCRSFSGGGVRLARERATERRDAASSRVSRFCPPRQSCHDWIGPPDKYSNLRPVHFHVPENESPLEQRLRELRQETQEWNQQFWAKQNLSFNKEKEEFIYSRLQAKGSGPRTESGQRATLDAEEMADFYKDFLSKNFQKHMCYNRDWYKRNFAITFFMGKVALERMWSKLKQKPKKTSG
What is the function of this protein?
Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain.
What are the official names of this protein?
Cytochrome c oxidase assembly factor 8, COA8, Apoptogenic protein 1, mitochondrial, APOP-1.
What is the protein family that this protein belongs to?
Belongs to the COA8 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: Y1599_STRA1
Sequence: MNKQERLGMSVYLYYNRDARKLYKYGDVHYHSRRLRYLVIYVNKEDIVSVSKEIKHLKFVKDVRLSAIDDIDQDFVGNLYR
What are the official names of this protein?
UPF0298 protein SAK_1599.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAC_ACIET
Sequence: MEIFDYDNILLLPRKCRVESRSECDTSVELGGRRFRLPVVPANMKTVVDEKICTWLAQNGYFYVMHRFDLDNVQFVKDMHAQGCFASISLGVKQPDYDTVDRFVAEGICPEYITIDIAHGHADSVKNMITYLKAKIPAAFVIAGNVGTPEAVIDLENWGADATKVGIGPGKVCITKLKTGFGTGGWQLSALKWCARVATKPIIADGGIRSHGDIAKSVRFGATMVMVGSLFAGHEESPGKTVEVDGELYKEYYGSASDFNKGEYKHVEGKRILEPIKGKLADTLTEMEQDIQSSISYSGGKKLMDIRKVNYVILGGDNAGEHLLM
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: DRR1_PEA
Sequence: MGVFNVEDEITSVVAPAILYKALVTDADTLTPKVIDAIKSIEIVEGNGGAGTIKKLTFVEDGETKHVLHKVELVDVANLAYNYSIVGGVGFPDTVEKISFEAKLSAGPNGGSIAKLSVKYYTKGDAAAPTEEQLKSDKAKGDGLFKALERYCLAHPDYN
What are the official names of this protein?
Disease resistance response protein Pi176.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: ATP6_RAT
Sequence: MNENLFASFITPTMMGLPIVVTIIMFPSILFPSSERLISNRLHSFQHWLIKLIIKQMMLIHTPKGRTWALMIVSLIMFIGSTNLLGLLPHTFTPTTQLSMNLSMAIPLWAGAVILGFRHKLKNSLAHFLPQGTPISLIPMLIIIETISLFIQPMALAVRLTANITAGHLLMHLIGGATLVLMDISPPTATITFIILLLLTVLEFAVALIQAYVFTLLVSLYLHDNT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GEL4_ASPFU
Sequence: MKFVYAAAGASLVGSALATLPVIEAKVLKACCWTIALDANSYGNKFFYSNNGTEFFIRGVAYQQEYQANGTSTENSDYTDPLANVDNCKRDIPYLKQLRTNVIRTYAVDPTKDHDECMKLLDDAGIYLITDLSAPSESINRADPAWNTDLYKRYTSVIDAFAKYSNVIGFFAGNEVANDNNNTNSIAYVKAAVRDMKSYIKSKDYRSSLLVGYATDDDAHIRADLADYLVCGDKESSIDMFGYNIYEWCGDSSFEKSGYKDRTEEFSKYPVPAFFSEYGCIDPKPRKFTDVAALYGPQMNDVWSGGIVYMYFQEANDYGLVSVSGDNVKTKEDFSYLSVQMQKVTATGVNSASYTASNTAVPTCPSVGAKWEASNKLPPSPNSELCDCMVETLSCTVKDSVDEKEYGDLFDYLCAAGVCGGINSNSTSGDYGAYSVCSAKQKLSFVMNQYYKKNNKAATACDFDGKAQTKKGADASGSCASLISQAGTAGTGSVTAGATGSSGSGSASETSKGAAGVAASPMAVKVGNWQFGAYIATALFAGVGMLVL
What is the function of this protein?
Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.  Involved in cell wall morphogenesis (By similarity).
What are the official names of this protein?
1,3-beta-glucanosyltransferase gel4, Glucan elongating glucanosyltransferase 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 72 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: MTMR2_CHICK
Sequence: MEEPPLLPGETIKDMAKDVTYICPFTGAIRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLEIVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFPENGWKVYDPIWEYRRQGIPNESWRLSKINEHYELCDTYPAILAVPVNIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLSLLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCSSEQQRVKESLPKKTVSLWSYINSQLEDFTNPLYVSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPVHNRYKELLAKRAELQKKVEELQREITNRSTSSSERAGSPAQCVTPVQTVV
What is the function of this protein?
Phosphatase that acts on lipids with a phosphoinositol headgroup.  Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).
What are the official names of this protein?
Myotubularin-related protein 2, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Partly associated with membranes.
Protein: PPA26_ARATH
Sequence: MNHLVIISVFLSSVLLLYRGESGITSSFIRSEWPAVDIPLDHHVFKVPKGYNAPQQVHITQGDYDGKAVIISWVTPDEPGSSQVHYGAVQGKYEFVAQGTYHNYTFYKYKSGFIHHCLVSDLEHDTKYYYKIESGESSREFWFVTPPHVHPDASYKFGIIGDMGQTFNSLSTLEHYMESGAQAVLFLGDLSYADRYQYNDVGVRWDSWGRFVERSTAYQPWLWSAGNHEVDYMPYMGEVTPFRNYLQRYTTPYLASKSSSPLWYAVRRASAHIIVLSSYSPFVKYTPQWHWLSEELTRVDREKTPWLIVLMHVPIYNSNEAHFMEGESMRAAFEEWFVQHKVDVIFAGHVHAYERSYRISNVRYNVSSGDRYPVPDKSAPVYITVGDGGNQEGLAGRFTEPQPDYSAFREASYGHSTLDIKNRTHAIYHWNRNDDGKKVATDEFVLHNQYWGKNIRRRKLKKHYIRSVVGGWIAT
What is the function of this protein?
Metallo-phosphoesterase involved in phosphate metabolism.  Acid phosphatase activity with phosphoenolpyruvate, inorganic pyrophosphate, phenyl-phosphate and p-nitrophenyl-phosphate as the most effective substrates.  No activity with phytic acid, phosphocholine or bis-p-nitrophenyl-phosphate.  Has a peroxidase activity at alkaline pH.
What are the official names of this protein?
Bifunctional purple acid phosphatase 26.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
What are the subcellular locations of this protein?
Vacuole.
Protein: DXR_TRIV2
Sequence: MKSITLVGSTGSIGTQTLDIVSQYPDQFRIVGLAAGSNVEMLAEQIRQFRPQIAAISAAEKLPALQAAIKDLDPQPILLGGEAGVIEVARYGDAETVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCLQGVPKGGLRKILLTASGGAFRDWDVERLAEVTVADALKHPNWSMGRKITVDSATLMNKGLEVIEAHFLFGLDYQDIEIVIHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWEPLNLVKAGNLTFREPDHQKYPCMQLAYAAGRAGGSMPAVLNAANEQVVALFLDEKIKFLDIPRCIELVCDRHQNDNCANPSLDDILAADQWARQEVLTATKNLASQPQIISVN
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: GCS2_BURCH
Sequence: MALETFVNSEPFTFGVELEIQVVNTHNYDLTKAASDLMRLIQGETFPGNITPEITESMIELSTGICHSHEQAVSELHAIRDVLVKAADQLNVGLAGGGTHAFQQWSDRQIYDAPRFQYISELYGYLAKQFTVFGQHVHIGCPDPDSALFLLHSMSRFIPHFIALSASSPFVQNVDTGFHSARLNSVFAFPLSGRAPFVLTWDSFEEYFTKMVNTGVVNSMKDFYWDIRPKPGYGTIEVRVMDTPLSVDRAAAIACYIQTLARYLLTDRPLKLSEDDYLVYTFNRFEACRFGLEGTCVNPQTGERRTIAEDILDTLDRIAPHAAALGSRAALDEIGALAKARVNDASWLRTVFKQEKSLNETVRQQCLRWRE
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: SDHD_BURTA
Sequence: MLMHDVRPLPLDPNLLAILQAGSPTLWLNPHQGEPLPDFAPTAADLAEAGARLHRCAGLLAELFPELRPLGGRIASPLQPAEPLKRADHAQAGAWFVKRDDALPVAGSIKARGGFHEVLALAESIAERHGLVSAGADRRALASGEAHALFARHTVMVGSTGNLGLSIGMLASALGFRTVVHMSADAKAWKRARLRTRGVDVVEHAGDYAKAVDAGRRQAAGMPRCHFVDDEGSRMLFLGYATAAAELAAQLAQAGRPVDARHPLFVHLPCGVGGAPGGIAYGLKARYGEHVHVFVAEPTASPCVLVQLASGGAHPVSVYDVGLDNRTEADGLAVAQASHLAGPLLRAQAAGVFTVDDRQLFAHLLDARERLGIDLEPSAAAAFGGPAWLAGSEAGRAYLRGRGIVPEAATHVIWATGGSLVPAEEHRRFQARACAQRRESGAGA
What are the official names of this protein?
Probable D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: TRMFO_ANADE
Sequence: MGDTRVTVIGGGLAGSEAAWQLARAGVAVELVEMKPERRSPAHVLPGLAELVCSNSLRSDNPQNAVGLLHEELRRLGSLVLGCADATRVPAGDALAVDRERFSEAVTARLSGHPGVRIVHREVEDLPPPPALAVIATGPLTGDALAARLAEATGGRLHFYDAIAPIVAAESIDRSIAYARSRYGKGSGDDYLNLPLDEAQYHAFVDALLQGEKVPAHGFEEPRYFEGCLPIEVMAERGTEVLAHGPLKPVGLEDPRTGRWPHAVVQLRREDVEGTAWNLVGFQTRLTWPEQRRIFRAFLPGLANAEFVRLGQIHRNTFVDAPRVLAPDLSVRAAPHLFLAGQITGVEGYVESAACGLMAARAVLDRLAERAFRPPPAATALGALHRHLTGEAHPPGYDYQPSNVVFALFPPLTGRHRGKAGRKEAHVERARKELAPWIDTAPPPAVPAAG
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSPA_BORBN
Sequence: MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMNVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTEIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
What are the official names of this protein?
Outer surface protein A.
What is the protein family that this protein belongs to?
Belongs to the OspA lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: LPXC_ACIB3
Sequence: MVKQRTLNRVVKASGIGLHSGQKVMINFIPHTVDGGIVFRRIDLDPPVDIPANALLIQEAFMCSNLVTGDIKVGTIEHVMSAIAGLGIDNLIVEVSASEVPIMDGSAGPFIYLLMQGGLREQDAPKKFIKILKPVEALIDDKKAIFSPHNGFQLNFTIDFDHPAFAKEYQSATIDFSTETFVYEVSEARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFADEFVRHKILDAVGDLYLLGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDEKDCPIPYVSVT
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.