PharMolix/UniProtQA huggingface dataset:
Protein: CITE4_BOVIN
Sequence: MADHLMLAEGYSLVPRPPPAAPAHGPHALRTLQPYSSPGLDSGLRPRGAPLGPPPPPQGTVAYGAFGPSPTFQPFPAVPPPAAGNAHLQPVATLYPGRATMPPGAPGGPSGPQPAPGAPAPPLQPPAHALGGMDAELIDEEALTSLELELGLHRVRDLPELFLGQSEFDCFSDLGSAPPAGSVSC
What is the function of this protein?
Acts as transcriptional coactivator for TFAP2/AP-2.  Enhances estrogen-dependent transactivation mediated by estrogen receptors.  May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP.  May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells (By similarity).
What are the official names of this protein?
Cbp/p300-interacting transactivator 4.
What is the protein family that this protein belongs to?
Belongs to the CITED family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CYB_MAIZE
Sequence: MTIRNQRFSLLKQPIYSTLNQHLIDYPTPSNLSYWWGFGCLAGICLVIQIVTGVFLAMHYTPHVDLAFNSVEHIMRDVEGGWLLRYMHANGASMFLIVVHLHIFRGLYHASYSSPREFVWCLGVVIFLLMIVTAFIGYVPPWGQMSFWGATVITSLASAIPVVGDTIVTWLWGGFSVDNATLNRFFSLHHLLPLILAGASLLHLAALHQYGSNNPLGVHSEMDKIASYPYFYVKDLVGRVASAIFFSIWIFFAPNVLGHPDNYIPANPMPTPPHIVPEWYFLPIHAILRSIPDKAGGVAAIAPVFISLLALPFFKEMYVRSSSFRPIHQGIFWLLLADCLLLGWIGCQPVEAPFVTIGQISSFFFFLFFAITPIPGRVGRGIPKYYTE
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPOB_CRUWA
Sequence: MLGDGKEGTSTIPGFNQIQFEGFYRFIDQGLIEELSKFPKIEDIDHEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVSAGLIWKTSRNMEEQRIFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYQSELDHNGISVYTGTIISDWGGRLELEIDKKARIWARVSRKQKISILVLSSAMGLNLREILENVCYPEIFLSFLTDKEKKKIGSKENAILEFYQQFSCVGGDPIFSESLCKELQKKFFHQRCELGRIGRRNINSRLNLNIPQNNIFLLPRDILAAADHLIGMKFGMGTLDDMNHLKNKRIRSVADLLQDQLGLALARLENVVKGTISGAIRHKLIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTGRTANFRIRDIHPSHYGRICPIDTSEGINVGLIGSLSIHARIGDWGSLESPFYELFEKSKKARIRMLFLSPSQDEYYMIAAGNSLALNRGIQEEQAVPARYRQEFLTIAWEEVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVPAIAEHEGKILYTDTEKIVFSSNGDTLSIPLIMYQRSNKNTCMHQKPQVRRGKCIKKGQILADGAATVGGELALGKNILVAYMPWEGYNFEDAVLISECLVYGDIYTSFHIRKYEIQTHVTTQGPERITKEIPHLEGRLLRNLDKNGIVMLGSWVETGDILVGKLTPQVAKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWVQKKGGSSYNPEIIRVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFECSLGLAGSLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRIFDGRTGDPFEQPVIIGKPYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIIGGTIPKPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SRX23_SARPE
Sequence: MKSFVLFAACMAIVALSSLAHAYPQKLPVPIPPPTNPPVAAFHNSVATNSKGGQDVSVKLAATNLGNKHVQPIAEVFAEGNTKGGNVIRGATVGVQGHGLGASVTKSGNGIAESFRKQAEANLRLGDSASLIGKVSQTDTKIKGIDFKPQLSSSSLALQGDRLGASISRDVNRGVSDTLTKSISANVFRNDNHNLDASVFRSDVRQNNGFNFQKTGGMLDYSHANGHGLNAGLTRFSGIGNQANVGGYSTLFRSNDGLTSLKANAGGSQWLSGPFANQRDYSFGLGLSHNAWRG
What is the function of this protein?
Sarcotoxin II is an antibacterial protein which plays a role in the inflammatory response of this insect.  The main effect of sarcotoxin II on E. coli may be the inhibition of cell wall synthesis, including septum formation.
What are the official names of this protein?
Sarcotoxin II-3.
What is the protein family that this protein belongs to?
Belongs to the attacin/sarcotoxin-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: I13R2_RAT
Sequence: MALMAVNTRCLCLFLLCTITGHSLEIKVNPPQDFEILDPGLLGYLYLQWKPPVVMDNFKECKLEYELKYRNVDSDSWKTIITRNLIYKDGFDLNKGIEGKIRTHLSEHCTNGSEVQSPWTEASYGIADEGSLGTKIQDMKCIYYNWQYLVCSWKPGKTVHSDTNYTMFFWYEGLDHALQCADYLQDNEKNVGCKLSNLDSSDYKDFFIRVNGSSKLEPIRSSYMVFQLQNIVKPLPPEFLHISVENSIDIRMKWSTPGGPIPPSCYTYEIVVREDDISWESATDKNDMKLKRRANESEDLCFFVRCKINIYCADDGIWSEWSEEECWEGYTGPDSKIVFIVPVCLFFIFLLLLLCLIVEKEDPEPTLSLHVDLNKEMYAYEETLC
What is the function of this protein?
Binds as a monomer with high affinity to interleukin-13 (IL13).
What are the official names of this protein?
Interleukin-13 receptor subunit alpha-2, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, IL-13R-alpha-2, IL-13RA2.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 5 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CYC4_CHACT
Sequence: MAKFATQLFLLTASVVMLEVQSSIVIMQDPDLGRKLIMNPANGASCGETCFTGICFTAGCSCNPWPTCTRNGLNPESI
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Chassatide C4, Cyclotide chaC4.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: CX6B1_RAT
Sequence: QNXLDFHR
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1, COX VIb-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 6B family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: RNB_PECAS
Sequence: MFQDNPLLAQLKQQLHSKTPRVEGVVKGTDKGFGFLEADGQKSYFIPPPHMKKVMHGDRITATLHTEKDREIVEPETLIEPFLTRFVGRIHKKDDRLSITPDHPLLKEAIPCRAARDVTDDFQEGDWAVAEMRRHPLKGDRGFHAELTQYITTGDDPLVPWWVTLSRHNLERSAPEVETTERHDGELVREDLTALNFVTIDSASTEDMDDALYVQDNGDGSLQLTIAIADPTAYVDAGSELDNIARQRAFTNYLPGFNIPMLPRALSDDICSLRPNERRPVLACRVTIAADGALGDDIHFFAASIESKAKLAYDNVSDWLENQGEWQPQNEEIAEQIRLLHRLCLARSEWRTTHALVFKDRPDYRFLLGEKGEVLDIVVEHRRIANRIVEESMIAANVCAAIVLRDKLGFGIYNVHNGFDPASIEQAVAVLDTHGVQADAQTLLTLDGFCTLRRELDAQPTQFLDSRIRRFQSFAEVSTTPGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAVITGQAAEKPQDDVTVQLAERRRLNRMAERDVGDWLYARYLKDKAGTDIRFNAEIIDVTRGGLRVRLLDNGAVVFIPSSFIHAVRDELVCSQEMGTLSVKGEVVYRQGDTLDVIIAEVRLETRGIVAKPAA
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_SOLTU
Sequence: MRGGLWQLGQSITRRLAQADKKTIGRRCFASDADLKKTVLYDFHVVNGGKMVPFAGWSMPIQYKDSIMDSTVNCRENGSLFDVSHMCGLSLKGKDTIPFLEKLVIADVAGLAPGTGSLTVFTNEKGGAIDDSVVTKVTNDHIYLVVNAGCRDKDLAHIEEHMKSFKSKGGDVSWHIHDERSLLALQGPLAAPVLQYLTKDDLSKMYFGEFRVLDINGAPCFLTRTGYTGEDGFEISVPSENALDLAKALLEKSEGKIRLTGLGARDSLRLEAGLCLYGNDMEQHTTPVEAGLTWAIGKRRRAEGGFLGAEVILKQIEEGPKIRRVGFFSSGPPPRSHSEIQDSNGQNIGEITSGGFSPCLKKNIAMGYVKTGNHKAGTNVKIVIRGKSYDGVVTKMPFVPTKYYKP
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, mitochondrial, Glycine cleavage system T protein, GCVT.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HCP_PHOPO
Sequence: MFCIQCEQTLEAPKKKGCAYATGMCGKTAEISDLQDVLVYILQGVSYWADLAHKFDIIDDEINHWAPRAFFATLTNVNFDRERILALANLAENYKTRLKQAVIAATTLAQQPLPTLPTVAEFTLPNTIDAILTLAPQVAVNRGYETINEDVIGLRLLCLYGLKGAAAYMEHARVLGQTNNAIYAQYHHIMSWLGTDPTDLNALLECSMEIGLMNYKVMEMLDLGETNTFGHPLPSQVNVKPIQGKCILVSGHDLHDLEKILQQTEGKHINVYTNGEMLPAHSYPELKKYPHLVGNYGSAWQNQQLEFANFPGAIVMTSNCLINPNVGKYADRIFTRSIVAWPGVAHIEGDDFSQVIDCALALDGFQHTEIEHMITIGFGRNALMNAAPAVIDQVKQGNINHFFLVGGCDGAKEERSYFTDFAAQVPQDSLILTLACGKYRFNKNNFGDINGIPRLLDVGQCNDAYSAIQLALALANEFDCSINELPLTLVLSWFEQKAIVILLTLFALGVKGIYTGPTAPAFLTDNLLAIIAEKFDMRSISTPEADLNTILSA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNY_DESPS
Sequence: MFFIEHPFVYLGLDLIVGCLIGFFLRKQLVERQQQNIQAQSKQIIENAIIDAEQLKKEALLQSKEEVYQIKQSLEAEVKLERDDLKDEHRQLKKQRDNIKRENERFEKRQSRHVVAEKALERRLREVDVKHEEADNEILKQRDELARIAGITQDEAKKLLMESIESEAQMDAAKRLSKIENEMKLEADRKARSILALAICRYAGDYVADKTVSMVPLPSDEMKGRIIGREGRNIRAIEAATGIDIIIDDTPEAVILSGFNPVRREVARLALIQLISDGRIHPGRIEEVVEKVSKELDEVMCEAGEQATFDVGAHGVHVELIKLLGRLRYRTSYGQNVLQHSLEVAFLCGIMAAELGIDVKMAKRAGLLHDIGKAVDHEVEGSHAVIGRDLAKKYGEPDEIVYAIGAHHADQPPKSVLDILVQAADALSGARPGARKEMLQSYVKRLEDLEAIANKFPGVDKSYAIQAGRDLRIIADAQKISDAEATLLSRNIAASIEEKLTYPGQIRVTVIRETRSVEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: COMB_CLOB6
Sequence: MNIDIVISADHIDEKRLINKTVIIIDILRATSVITTAINNGCKKVIPVLTVEEAKDIAKNSKEDIILGGERNALKIDGFNFSNSPLEYTKKYVEGKTVVLSTTNGTRAINNSFNAKTILISALINSKATAKAIDKLNEDLIIINSGTNGQFSIDDFICSGYLIDCLYNIRKDLELSDIAKTAHYIYTNNKDIESFVKKATHYSRLKSLNLEKDLEYCFQKDIIDVVPQYKDGYIIKLNI
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: RXA_XENLA
Sequence: MHLHSPSLMADGSFSLSGHLLRSPGGNPSRLHSIEAILGFVKEDSVLGSFQSEISPRNAKEVDKRSSRHCLHKMTEEIHPQQEHLEDGQTDGYGDPYLGKTSSECLSPGLSTSNSDNKLSDDEQQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKLEVTSMKLQDSPMLSFNRSPQPSAMSALSSSLPLDSWLTPTLSNSTALQSLPGFVTTPPSLPGSYTPPPFINPVSVGHALQPLGAMGPPPPYQCGANFVDKYPLEETDPRNNSIASLRMKAKEHIQFIGKPW
What is the function of this protein?
Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.
What are the official names of this protein?
Retinal homeobox protein Rx-A, Rx1A, Xrx1, Retina and anterior neural fold homeobox protein A.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRC_PSEPK
Sequence: MSDRLTLLRPDDWHIHLRDGAVLPHTVGDVARTFARAIIMPNLVPPVRNVTEAGAYRERILAARPAGSRFEPLMVLYLTDRTSPEDVRAAKASGFVYAAKLYPAGATTNSDSGVTSIDNIFPAIEALAEVGMPLLVHGEVTRSEIDVFDREKRFIDEHMRRVVERFPTLKVVFEHITTSDAAQFVTEAPANVGATITAQHLLYNRNHMLVGGIRPHFYCLPILKRNTHQVALLDAATSGNPKFFLGTDSAPHARHAKEAACGCAGCYTAYAAIEMYAEAFEQRNALDKLEGFASLHGPAFYGLPANTDTITLVREEWTAPESLPFGEQTVVPLRAGEKLRWRLLEKNA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: RPOZ_RALSO
Sequence: MARITVEDCLKQIPNRFELALAATYRARQLVQGHTPKVDAKDKPTVTALREIAAGQVGIEMLKKVPS
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: DER_LACLS
Sequence: MSLPTVAIVGRPNVGKSTIFNRIAGERISIVEDIPGVTRDRIYATGEWLTRKFNIIDTGGIELSDEPFMTEIRAQAEIAMTEADVIIAVVDGETGITDADEAVANILYRTDKPVILIVNKVDNPERRMEIFDFYSLGLGDPYPVSAVHGIGTGDVLDAIVQNLPNEIEEENEDVIKFSLIGRPNVGKSSLINAILGEDRVIASPIAGTTRDAIDTHFVDSEDQEFVMIDTAGMRKSGKIYENTEKYSVMRAMRAIDRSDIVLMVINAEEGIREYDMRIAGFAHEAGKGILIVVNKWDTLEKDNDTMKKFELEIRTKFKFLDYAPIVYVSAKTGQRLNKLPDMIKEIHHAQNLRISSSVLNDVIMDAVAINPTPTDKGKRLKIFYATQVAIKPPTFVVFVNEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: CP27B_MOUSE
Sequence: MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPERSINLQFVDR
What is the function of this protein?
A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis.  Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1-alpha position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:15972816, PubMed:10092858).  Has 1-alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway.  Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR.  Also active on 25-hydroxyvitamin D2 (By similarity).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:15972816, PubMed:10092858).
What are the official names of this protein?
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, 25-OHD-1 alpha-hydroxylase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, VD3 1A hydroxylase, Calcidiol 1-monooxygenase, Cytochrome P450 subfamily XXVIIB polypeptide 1, Cytochrome P450C1 alpha, Cytochrome P450VD1-alpha, Cytochrome p450 27B1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion membrane.
Protein: NNRE_HUMAN
Sequence: MSRLRALLGLGLLVAGSRVPRIKSQTIACRSGPTWWGPQRLNSGGRWDSEVMASTVVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSRSPPTVLVICGPGNNGGDGLVCARHLKLFGYEPTIYYPKRPNKPLFTALVTQCQKMDIPFLGEMPAEPMTIDELYELVVDAIFGFSFKGDVREPFHSILSVLKGLTVPIASIDIPSGWDVEKGNAGGIQPDLLISLTAPKKSATQFTGRYHYLGGRFVPPALEKKYQLNLPPYPDTECVYRLQ
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.  Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed:23719382).
What are the official names of this protein?
NAD(P)H-hydrate epimerase, Apolipoprotein A-I-binding protein, AI-BP, NAD(P)HX epimerase, YjeF N-terminal domain-containing protein 1, YjeF_N1.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
What are the subcellular locations of this protein?
Mitochondrion. Secreted. Note=In sperm, secretion gradually increases during capacitation.
Protein: YEIS_ECOL6
Sequence: MDVQQFFVVAVFFLIPIFCFREAWKGWRAGAIDKRVKNAPEPVYVWRAKNPGLFFAYMVAYIGFGILSIGMIVYLIFYR
What are the official names of this protein?
Uncharacterized protein YeiS.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YGW8_YEAST
Sequence: MVLVLSPRLVNQFCDVLKIKEGRTSLNTTCMDSFSLLSMVLWRIFTEQSNLKSKSTSLKDIPIPGFFTKIFVMASSSMELNVIVIGIVNDPLLMSWGMVKLGVSCSLINKRFDSMTVCIRNIASLHEILQIPLARDLGCVIMSRSRISSCGIVGKSTFCTLIPLFKISNFFLDGEFKAVDNFSRIRSLKELSPNTASLNLNDMTMLKFLAVVFFLL
What are the official names of this protein?
Putative uncharacterized protein YGL218W.
Protein: TDRKH_MOUSE
Sequence: MSTERTSWTNLSTIQKIALGLGIPASATVAYILYRRYRESREERLTFVGEDDIEIEMRVPQEAVKLIIGRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKAKAAIHQILTENTPVFEQLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLLSRLIKISGTQKEVAAAKHLILEKVSEDEELRKRIAHSAETRVPRKQPISVRREEVTEPGGAGEAALWKNTNSSMGPATPLEVPLRKGGGDMVVVGPKEGSWEKPNDDSFQNSGAQSSPETSMFEIPSPDFSFHADEYLEVYVSASEHPNHFWIQIIGSRSLQLDKLVSEMTQHYENSLPEDLTVHVGDIVAAPLSTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCALKDLRALRSDFLSLPFQAIECSLARIAPTGEEWEEEALDEFDRLTHCADWKPLVAKISSYVQTGISTWPKIYLYDTSDEKKLDIGLELVRKGYAVELPEDMEENRTVPNMLKDMATETDDSLASILTETKKSPEEMPHTLSCLSLSEAASMSGDDNLEDDLF
What is the function of this protein?
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity.  The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.  Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs.  May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
What are the official names of this protein?
Tudor and KH domain-containing protein, Tudor domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the Tdrkh family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline.
Protein: DNE21_AGRFC
Sequence: MSAPRYAELQVTTHFSFLRGASSCDELFEQAKNLGIEALGVVDRNSLAAIPRAYEAANNHGVRLVIGCRLDLDDDLSVLVYPMDRAAYGRLCRLLSVGKKRGGKGKCRLSWDDLVAYGEGLIVVLLADLADDLCALRLRRLKAAFADRAYMALSLRRRPNDQMRLFELSGMAQAAGVPTVVTNDVLFHVPERRMLQDVVTCIRHNCTIDEAGFRRERHADRYMKPPEEMHRLFARYPEALSRSLEIAKRCKFSLKELVYQYPEERSLPGLTAQQALEKMVWEAVPGRYPNGLPEKVEKALHHELDVVGRLQYASYFLTVNAIVRYARSKDILCQGRGSAANSVICFVLGITAIDPALFSNLVFERFVSENRGEPPDIDVDFEHQRREEVIQWVYDTYGRDKAALCSVVTRYRGRGALRDVGKVLGLPEDLTKLLSSQVWRWSEGVGEKQVKELNLNMEDRRLKLAFELANQLVGTPRHHSQHPGGFVLSHDRLDELVPIEPAAMNDRQIIEWDKDDIDIVKFMKMDCLALGMLSCMKRGFDLLEARTGEKYDLAAMPPDDPATFAMIQKADTLGTFQIESRAQMSMLPRLKPAKFYDLVIQVAIVRPGPIQGDMVHPYLRRRQGKEPVLYEKPQLENILKKTLGVPLFQEQAMRIAMDCADFTADEADQLRRAMATFKNVGTISKFKEKLVTGMVANGYDKEFAERIFKQLEGFGSYGFPESHAASFALIAYASSWLKCHHPDIFCTAILNSQPMGFYAPAQIVRDARDHGVEVRPVCVNNSRFDCTLEPTGKKNDKGEERFAVRLGLRMVKGLSNDHAADIVAARQDRPFASVDDLWRRAGVPAAALVCLAEADAFLPSLRLARREALWAIKALRDEPLPLFAAAAIRENAVIEELQEPSVALRPMTDGGEVVQDYGHVGLTLREHPMTFLRRDLSRRRIVTCAEAVRVRDGTWLETAGLVLVRQRPGSAKGVIFMTLEDETGIANAVLWVKTFEKYRRVVLSAGMVGIYGKIQREGEVVHLVAHRLTDLSHALASVGERNNAFPLPHGRGDEFHHGMPDDHRAIRKRPPPSNHDDDEVERIKVISRNFH
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase 1.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLQE3_MYCTO
Sequence: MTRLVPALRLELTLQVRQKFLHAAVFSGLIWLAVLLPMPVSLRPVAEPYVLVGDIAIIGFFFVGGTVFFEKQERTIGAIVSTPLRFWEYLAAKLTVLLAISLFVAVVVATIVHGLGYHLLPLVAGIVLGTLLMLLVGFSSSLPFASVTDWFLAAVIPLAIMLAPPVVHYSGLWPNPVLYLIPTQGPLLLLGAAFDQVSLAPWQVGYAVVYPIVCAAGLCRAAKALFGRYVVQRSGVL
What is the function of this protein?
Part of the ABC transporter complex involved in fluoroquinolones export.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Fluoroquinolones export permease protein MT2761.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DTX2_HUMAN
Sequence: MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPYPVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGRYRHSMTNLPAYPVPQHPPHRTASVFGTHQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGLPVCLSRAPQPTSPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
What is the function of this protein?
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.  Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context.  Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1.  Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase DTX2, Protein deltex-2, Deltex2, hDTX2, RING finger protein 58, RING-type E3 ubiquitin transferase DTX2.
What is the protein family that this protein belongs to?
Belongs to the Deltex family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.