PharMolix/UniProtQA huggingface dataset:
Protein: RPOB_ACIBY
Sequence: MAYSYTEKKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQDGKSPKNREDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDVRECILRGSTYAAPMRVKIRLIIKDRETKSIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKTHSSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQILNLFYEKVPVYLDMGSYQIDLVPERLRGEMAQFDITDNEGKVIVEQGKRINARHVRQMEAAGLTKLSVPDEYLYERITAEDITLRDGEVIAANTLLSHEVMVKLAEGGVKQFNILFTNDIDRGSFVADTLRADLTRDREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKFNRRLGRPYEVGTDQKSREVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDDVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVARDSGVCVIANRGGVIEYVDASRIVIRVNEDEMVAGEAGVDIYNLIKYTRSNQNTCINQNVIVNLGDKVARGDILADGPSTDMGELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGLEKDDRALAIEKAQLDSYRKDLKEEYKIFEEAARERVIRLLKGQESNGGGSTKRGDKLSEDLLSGLELVDLLEIQPADEAIAERLTQIQVFLKEKSAEIDEKFAEKKRKLATGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILETHLGMAAKGLGDKIEKMLKEQRTVLELREFLDKIYNKVGGEQEDLDSLTDEEILALAGNLRAGVPLATPVFDGAEESQIKDLLELADISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIELKNGD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RL6_DESHD
Sequence: MSRIGKRPISIPGGVDVNIEGNVVTVKGPKGTLTKEMHSLINIAVEEQQIVVTRPDDQPLSRSLHGLTRTLVANMVEGVTKGFSKSLDMVGVGYRAAKQGNKLVLSVGKSHPVELIPFEGIEVEVPAQNKIIVKGMDKELVGDFAAEIRKERPPEPYKGKGIKYENEVVRRKAGKTGAKKGGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: KGUA_STAES
Sequence: MDKEKGLLIVLSGPSGVGKGTVRKKIFEDPTTSYKYSISMTTRHMREGEIDGVDYFFKTKEEFEALIKDDQFIEYAQYVGNYYGTPVQYVKDTMEEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLDDLKERLVGRGTESDEKIQSRVNEARKEVEMMNLYDYVVVNDEVELAKNRIQSIVEAEHLKRERIEAKYRKMLLEVKK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCP_YERP3
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLVAVLQGLSAWALQARELGIIDSQIDSFAPRAFFSTLTNVNFDSDRIVEYAKDAILLRHSLAVRCRLLDSTITVDHPLAELQLVADDIPSLLQQSQQFALNNDKADVGDDIHGLRMLCLYGLKGAAAYMEHAHVLGQSDEQIYAEYHAYMAWLGTQPRDVDTLLNNAMGIGKMNFNVMAILDQGETQAYGDPQPTSVNVRPVAGKAILISGHDLKDLHMLLEQTQGTGINIYTHGEMLPAHGYPELKRYPHLVGNYGSGWQNQQTEFAKFPGPILMTSNCIIDPNVGNYGDRIWTRSIVGWPGVNHLDGDNFAPVIEQALGMAGFPYSELEHLITVGFGRQTLLNAADTVIDLVASKKLRHVFLVGGCDGSRTERSYFTDFARSVPQDCIIMTLACGKYRFNKLDFGTLEGLPRLLDVGQCNDAYAAIMLAVKLSEKLGCTVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIYTGPTAPGFLTDNLMAILYEKFGMQPITTVEQDMQAILGH
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_PSEU2
Sequence: MTMLKDPSKKYRAFPTIDLPDRTWPSKTIDAVPIWCSSDLRDGNQSLIEPMDAAKKLRFWKTLVSVGVKEIEASFPSASQTDFDFVRTLIEDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATCPSFRRIVFNQDKAGVKEIAVNAAKLFVKYAAQQPETQWTFQYSPETFSATELEFAKEVCDAVIEVWNPTPENKVILNLPATVEVATPNIYADQIEWFGRNITRRDSVLISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNLYTQGINPGLDFSDIDGVRKVVEECNQIPVHPRHPYVGDLVHTAFSGSHQDAIRKGFTQQKEGELWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAEQIHSLLRREYLQANVPYALISHKLQEENGNSSVDAEVHVDGETQHWRGKGKGALEALVAGLPVAVEIMDYNEHAIGSGTTAKAAAYIELRVNGERAVHGVGIDENITTASFRALFSALNRSLSQTQAKAA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: FGFR2_XENLA
Sequence: MLLLALLAFLLVSRTIARPSYSMVDDTTPEPEEPPAKYQISKADVFPVLPGEPLDLRCPLADGPLVTWTKDGAKLEVNNRTLIVRTYLQIKESTTRDSGLYACSVLKNSHFFHVNVTEASSSGDDEDDNDGSEDFTNDNNNIRAPYWTNTEKMEKKLHAVSAANTVKLRCPAREPHPSNEWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGIYTCIVENEHGSINHTYHLDVIERSSHRPILQAGLPANTTAVVGGDAEFVCKVYSDAQPHIRWVRYIEKNGSRFGVDGLPYFKVLKAAGVNVTDEEIEVLYVRNVSFEDAGEYTCIAGNSIGISQHSAWLTVHPAPVNPLEDNPVPYYMEIGIYSTGIFIIFCMVVVCVVCRMRQGAKKKKNFTGPPVHKLTKRIPLHRQVTVSADSSSSMNSTTPLVRITTRLLNSTDAMPLANVSEYELPHDPMWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKERPKESVTVAVKMLKDNATEKDLADLVSEMEMMKMIGKHKNIINLLGACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSCTYQIARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAIPSHRPTFKQLVEDLDRILTLTTNEEYLDLSAPLEQYSPSFPDSSCSASSSSGDDSVFSPDPMPHDPCLPKFQHVNGVVKT
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development.  Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development.  Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development.  Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts.  Phosphorylates PLCG1, FRS2 and PAK4.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation.  Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling.  Over-expressed FGFR2 promotes activation of STAT1 (By similarity).
What are the official names of this protein?
Fibroblast growth factor receptor 2, FGFR-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded (By similarity).
Protein: DNLJ_STRPM
Sequence: MKKRIKELTDLLNRYRYDYYTKDAPSVSDSDYDKLYRELVTLEQSYPEYVLQDSPTQQVGGTILKGFEKYRHQYPLFSLQDAFSREELDAFDKRVKAEFPNATYLAELKIDGLSISLSYENGFLQVGATRGDGNIGENITENIKKIKDIPHQLSEPLTITVRGEAYMSRQSFKAINEARQENGETEFANPRNAAAGTLRQLDTAVVAKRQLATFLYQEASPTARNQQNEVLAELADLGFSVNPYYQLTSSMDEIWNFIKTIEAKRDQLAYDIDGVVIKVNSLAMQEELGFTVKAPRWAIAYKFPAEEKEAEILSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIAEKDIRIGDTVIVYKAGDIIPAVLNVVMSKRNQQEVMLIPKLCPSCGSELVHFEDEVALRCINPLCPSLIQRSLEHFASRDAMNITGLGPAIVEKLFLAGFVHDVADIYQLTKEDFMQLDGIKEKSADKLLAAIEASKSNSAEKLLFGLGIRHIGSKVSRLILEVYGDISALLTAKEEEIARIDGLGSTIAQSLTQYFEQKTAAILVDELKTAGVNMHYSGQKVNSDAALFGLTVVLTGKLNQLNRNEAKDKLEALGAKVTGSVSKKTDLVIAGSDAGSKLEKAKSLGIRIEDEDWLRQL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RS8_MYCTA
Sequence: MTMTDPIADFLTRLRNANSAYHDEVSLPHSKLKANIAQILKNEGYISDFRTEDARVGKSLVIQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARQGVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: HEAT6_PONAB
Sequence: MAAVQVVGSLPSGQLREAPRDAIPEGGNGFRRLSARLCALRPDDSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRLQVIVDEQRLDFLLAYTISAIHQCSSWTHMEILQALAALVYCNGSKCQKYLLELLGETGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPMVLYPTPLPQYDGRTPIKPQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTGRVNLHEGNTWCPSSLGVQSLPLDGSGAAGKDGVSSPFSSSSWKRVSSSESDFSDAEGGMQSKMRSYQAKVRQVALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIASSIRELHRCLLLALVAESSSQTLTQIIKCLANLVSDAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLSNSNSATPHLSPPDWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKCMGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQAGACDALSSILPEAFSNLPKDRQILCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLEDKSLNVRANAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQYGSVDQYAGIWNALVTALQKSEDTRDFLEFKYCASLRTQICQALIHLLNLASASDLPCIKETLELNGNMVQSYILQFIKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPTGDTARRAVMGFLEEILAVCFDSSGSQGALPGLTNQ
What are the official names of this protein?
HEAT repeat-containing protein 6.
Protein: AAE1_ARATH
Sequence: MKMEGTIKSPANYVPLTPISFLDRSAVVYADRVSIVYGSVKYTWRQTRDRCVRIASALSQLGISTGDVVSVLAPNVPAMVELHFGVPMAGALLCTLNIRHDSSLVAVLLRHSGTKVIFADHQFLQIAEGACEILSNKGDKVPILVLIPEPLTQSVSRKKRSEEMMEYEDVVAMGKSDFEVIRPTDECDAISVNYTSGTTSSPKGVVYSHRGAYLNSLAAVLLNEMHSSPTYLWTNPMFHCNGWCLLWGVTAIGGTNICLRNVTAKAIFDNISQHKVTHMGGAPTILNMIINAPESEQKPLPGKVSFITGAAPPPAHVIFKMEELGFSMFHSYGLTETYGPGTICTWKPEWDSLPREEQAKMKARQGVNHLGLEEIQVKDPVTMRTLPADGVTMGEVVFRGNTVMNGYLKNPEATKEAFKGGWFWSGDLGVKHPDGYIELKDRSKDIIISGGENISSIEVESTLFTHPCVLEAAVVARPDEYWGETACAFVKLKDGSKASAEELISYCRDRLPHYMAPRSIVFEDLPKTSTGKVQKFVLRTKAKALVSLSKKGRSKL
What is the function of this protein?
Catalyzes the ligation of CoA on butanoate to produce butanoyl-CoA (PubMed:23300257).  Can also use hexanoate, pentanoate and 4-methylpentanoate as substrates with a lower efficiency (PubMed:23300257).
What are the official names of this protein?
Butanoate--CoA ligase AAE1, 4-methylpentanoate--CoA ligase AAE2, AMP-binding protein 1, AtAMPBP1, Acyl-activating enzyme 1, peroxisomal, Hexanoate--CoA ligase CCL3, Pentanoate--CoA ligase CCL3.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: IDN2_ARATH
Sequence: MGSTVILSSDDEDSDISESEMDEYGDKMYLNLKGGKLKVRLSPQAFICPYCPNKKKTSFQYKDLLQHASGVGNSNSDKRSAKEKASHLALVKYLQQDLADSASEAEPSSKRQKNGNPIQDCDHDEKLVYPWKGIVVNIPTTKAQDGRSAGESGSKLRDEYILRGFNPTRVRPLWNYLGHSGTAIVEFNKDWNGLHNGLLFDKAYTVDGHGKKDWLKKDGPKLGLYGWIARADDYNGNNIIGENLRKTGDLKTIAELTEEEARKQELLVQNLRQLVEEKKKDMKEIEELCSVKSEELNQLMEEKEKNQQKHYRELNAIQERTMSHIQKIVDDHEKLKRLLESERKKLEIKCNELAKREVHNGTERMKLSEDLEQNASKNSSLELAAMEQQKADEEVKKLAEDQRRQKEELHEKIIRLERQRDQKQAIELEVEQLKGQLNVMKHMASDGDAEVVKEVDIIFKDLGEKEAQLADLDKFNQTLILRERRTNDELQEAHKELVNIMKEWNTNIGVKRMGELVTKPFVDAMQQKYCQQDVEDRAVEVLQLWEHYLKDSDWHPFKRVKLENEDREVEVIDDRDEKLRELKADLGDGPYNAVTKALLEINEYNPSGRYITTELWNFKADKKATLEEGVTCLLDQWEKAKRKRGMA
What is the function of this protein?
Forms a complex with FDM1/IDNL1 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (PubMed:22570638, PubMed:22592791) and downstream of small interfering RNA (siRNA) formation (PubMed:22810086).  Required for de novo DNA methylation, siRNA accumulation and siRNA-mediated maintenance methylation (PubMed:19915591).  Required for several post-transcriptional gene silencing pathways (PubMed:20059743).  Binds double-stranded RNAs (dsRNAs) with 5'-overhangs through its XS domain (PubMed:19915591, PubMed:20059743).  Binds long non-coding RNA (lncRNA) in an AGO4-dependent manner and associates with DRM2, resulting in DNA methylation of RdDM target loci (PubMed:23246435, PubMed:24862207).  Mediates the silencing of a subset of MORC6 target loci (PubMed:27171427).
What are the official names of this protein?
Protein INVOLVED IN DE NOVO 2, Protein RNA-DIRECTED DNA METHYLATION 12.
Protein: PLSY_PSELT
Sequence: MNYILIGLISYFCGAIPFSYLLPKLRKIDIRRTGSGNVGGTNALRAAGPVIGFICMVLDGVKAFVPVLVFSLIFKDIHYTGISSIFAVLGHDFPVFLRFKGGKGVASTTGVFFALCPICGFTFLATWISITLLTKYVSLASIVGMYAASFVAFFFNKDYGVLFLLLSTLSTLRHSENIERLVNKSERKTDLIKIIKKRG
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAD_THEGJ
Sequence: MNILIFGPPGSGKSTHSRRIVEEYGLTYISSGDLIRGEIERKSSLGLEMAAYLSRGDLIPDTIVNTLIISRLRRQRENFILDGYPRTPEQVIALENYLYDHGIRLDLALEIFIDEDTSVERISGRRICPNCGAVYHITYNPPKVPGICDVCGTKLIQRTDDREEVVRKRYRIYIKNMEPIIKFYRAKGIYVRVDGDGLIPDVWKRIKPLLDYIHEREKKRKEHE
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_XANCB
Sequence: MSRPSLTRFLIEEQHAGRIDPELRQLITIVSRACKRISIAVSKGALGGVLGDAGTGNVQGEAQKKLDVLSNDILLEANAWGGHLAACASEEMDHSQPVPDQYPSGDFLLLFDPLDGSSNIDVNVSVGTIFSVLRAPKGTEKPGDEHFLQPGTQQVAAGYCIYGPSTMLVLTLGHGTHAFTLEREEGSFLLTQADMRVPEDTAEFAINMSNQRHWEPAMQAYVGDLLAGKDGARGKDFNMRWIASMVADVHRILTRGGIFIYPWDKKDAAKPGKLRLMYEANPMGMLVEQAGGAATTGRERILDIQPTQLHQRVPVFLGSKNEVAEATRYHVEFDKAQG
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JIP4_MOUSE
Sequence: MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLEATAHSRIRKERPISLGIFPLPAGDGLLTPDTQKGGETPGSEQWKFQELSQPRSHTSLKVSHSPEPPKAVEQEDELSDISQGGSKATTPASTANSDVSAIPPDTPSKEDNEGFVKGTDTSNKSEISKHIEVQVAQETRNVSTESGENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEDKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNATKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVANGQGETKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDIAGLDTEGSKQRSASQSSLDKLDQELKEQQKEFKNQEELSSQVWICTSTHSTTKVIIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEELSESGQVDKASLCGSMTSNSSAEMDSLLGGITVVGCSTEGLTGAATSPSTNGASPVIEKPPEMETENSEVDENIPTAEEATEATEGNAGSTEDTVDISQPGVYTEHVFTDPLGVQIPEDLSPVFQSSNDSDVYKDQISVLPNEQDLAREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGTPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSGGADLTADKAGSSAQEPSSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMCGNE
What is the function of this protein?
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12391307, PubMed:15767678).  Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (By similarity).  Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (PubMed:19056739).
What are the official names of this protein?
C-Jun-amino-terminal kinase-interacting protein 4, JIP-4, JNK-interacting protein 4, JNK-associated leucine-zipper protein, JLP, JNK/SAPK-associated protein 2, JSAP2, Mitogen-activated protein kinase 8-interacting protein 4, Sperm-associated antigen 9.
What is the protein family that this protein belongs to?
Belongs to the JIP scaffold family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Lysosome membrane. Note=Perinuclear distribution in response to stress signals such as UV radiation.
Protein: MK14A_CYPCA
Sequence: MSQKERPTFHRQEVNKTIWEVPVRYQNLSPVGSGAYGTVCSAYDEKTGLKVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASLISRMPSHEARTYINSLPQMPKRNFSEVFIGANPQAVDLLEKMLVLDTDKRITAAEALAHPYFAQYHDPDDEPEAEPFDQSFESRELDIEEWKRQTYEEVISFEPPVFDGDEMES
What is the function of this protein?
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors.  Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each.  Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase 14A, MAP kinase 14A, MAPK 14A, Mitogen-activated protein kinase p38a, MAP kinase p38a, cp38a.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: C76K7_ROSOF
Sequence: MDAFVVFSLAFLAAWFIVVFPRWSDSRRRRGPGGELPPGPPPLPIVGNILQLRGDPHKSFAQLAKTYGPLMSLRLGTQFAVVVSSPEMATEILQKHGHAFSNRSIPDAINIHGHNEVSWNTMPADSTGWKRIRRVGREKLFSHQALQQTEGQRQERLRKLADHVRGFSEQGRVMNVGEATFTTMTDLVFSTLFSIDLTDYGATDSIANKEFKEHVNAFTRYIGVPNISDFFPIFAPLDPQGIRRKIGHHLGSLLAFVQSMIEERLRERKASTYQKKNDFLDTLLDISEEGNGYDDLSIKEIRHFCVDIIVAGSDTSAATTEWAMVELLLHPDKLAKLKAELKSFLGEKSLVEGSDISKLPYLQATIKEVFRFHPAAPLLGPREAVEETQINGYTIPKNAKIMVNFWAMTRDPSIWKNPESFEPERFLGKDIDYEGQHFELIPFGSGRRICPGMPLASRMLHCMVATLCHNFDWELEGGAESKQRQREDVFGLALQKKFPLRAKPIKV
What is the function of this protein?
Monooxygenase involved in the biosynthesis of carnosate, a potent antioxidant labdane-related diterpene natural product (By similarity).  Catalyzes the oxidation of 11-hydroxyferruginol to produce carnosate (By similarity).  Mediates the conversion of miltiradien into miltiradien-20-al (PubMed:27703160).  Also involved in the production of pisiferic acid and derivative products from ferruginol (By similarity).
What are the official names of this protein?
Carnosic acid synthase, Cytochrome P450 76AK7, RoCYP76AK7, Miltiradien-20-al synthase, Pisiferic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SELA_STUS1
Sequence: MSSSHLPSVDKLLRDPACQPLQQRYGRQALLATLRDLLDELREPARRGQLAALELSEAVLAGRAGERLATQHKSRVRRVFNLTGTVLHTNLGRALLPDEAIEAITLAARYPLNLEFDLATGKRGDRDDLIEELIRELTGAEAVTVVNNNAAAVLLALNSLGARKEGIISRGELIEIGGAFRIPDIMARAGVKLHEVGTTNRTHAKDYEAAINPRSGLLMRVHTSNYSVQGFTASVATAELARIAHAHDLPLLEDLGSGSLLDLSRWGLPKEPTVQEALRDGADIVTFSGDKLLGGPQAGLIVGSKALIQKIKKNPLKRALRVDKLTLAALEAVLNLYRDPDRLAERLTSLRLLSRPQAEIRTQAERIAPTLAAVLGESWQVAVTDALGMIGSGAQPVARLPSAALCIRPQQPKRLRGRSLRQVEEALRCLPIPVLGRIDDDALWLDLRQLDDEPAFLQQLAHLQEELAR
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
Protein: YR800_MIMIV
Sequence: MDNMDEIIKEAVIYKRLAHGIYGQLGGDHYAVQVTTISGKKFIIHSTPEHGTVITDVTLSNKWTLVERIKITNQKTVKKLFKEISGKTTIKFVNYVTSGTCIGTTQHIKHKLTK
What are the official names of this protein?
Uncharacterized protein R800.
Protein: Y1168_HELPJ
Sequence: MYRKDLDNYLKQRLPKAVFLYGEFDFFIHYYIQTISALFKGNNPDTETSLFYASDYEKSQIATLLEQDSLFGGSSLVILKLDFALHKKFKENDINPFLKALERPSHNRLIIGLYNAKSDTTKYKYTSEIIVKFFQKSPLKDEAICVRFFTPKAWESLKFLQERANFLHLDISGHLLNALFEINNEDLSVSFNDLDKLAVLNAPITLEDIQELSSNAGDMDLQKLILGLFLKKSVLDIYDYLLKEGKKDADILRGLERYFYQLFLFFAHIKTTGLMDAKEVLGYAPPKEIVENYAKNALRLKEAGYKRVFEIFRLWHLQSMQGQKELGFLYLTPIQKIINP
What is the function of this protein?
Could be the functional equivalent of DNA polymerase III delta subunit (HolA).
What are the official names of this protein?
Protein jhp_1168.
Protein: RS8_NOVAD
Sequence: MAMTDPLGDMLTRIRNGQQAKKDSVLSPASKLRAHVLEVLQREGYIRGFSEDTTGVHPQLRIELKYFEGQPAIKHVARVSKPGRRVYSGSKELPVIRNGLGITIVSTPKGVLSDAEARAANVGGEVLAEVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.