PharMolix/UniProtQA huggingface dataset:
Protein: AT132_HUMAN
Sequence: MSADSSPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSWQLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQKRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDDVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGPYCAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEPAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKDPDQAASYTVEPDPRSRHLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTNVPFLVALALLSSVLVGLVLVPGLLQGPLALRNITDTGFKLLLLGLVTLNFVGAFMLESVLDQCLPACLRRLRPKRASKKRFKQLERELAEQPWPPLPAGPLR
What is the function of this protein?
ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (PubMed:31996848).  Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (PubMed:31996848).  Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024).  Contributes to cellular zinc homeostasis (PubMed:24603074).  Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (PubMed:26134396).  Required for proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957).  Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822).  Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141).  Promotes secretion of exosomes as well as secretion of SCNA via exosomes (PubMed:25392495, PubMed:24603074).  Plays a role in lipid homeostasis (PubMed:31132336).
What are the official names of this protein?
Polyamine-transporting ATPase 13A2.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
Protein: SUFS_DICD3
Sequence: MNYPVEHYPIDRVRADFPILQQSVNGQPLAYLDSAASAQKPLAVIDRERDFYLHEYAAVHRGIHTLSARATSAMEEVRAKVATFIHAASAEDIVFVRGTTEAINLVANSYGRTAFQPGDNLVISEMEHHANIVPWQMLAQARGLTLRVLPITDDGELDMAQLPALLDERTRLVAVTQVSNVLGTVNPLAEIIRQAHACGAKVLVDGAQAVMHQAVDVQALDCDFYAFSGHKLYGPSGIGVLYGKSELLQAMPPWEGGGAMIREVSLTQGTTYADPPWRFEAGSPHVAGIIGLGAALDYVSALGVDAIQAHEGLLMRYALASLAEVPTLRLYGPVHRQGVIAFNLGRHHAFDVGSFLDQYGIAIRTGHHCAMPLMSRYGVPSMCRASLALYSCQDEIDRLVAGLHRIHRLLGE
What is the function of this protein?
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation.  Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine.  Selenocysteine lyase activity is however unsure in vivo.
What are the official names of this protein?
Cysteine desulfurase, Selenocysteine beta-lyase, SCL, Selenocysteine lyase, Selenocysteine reductase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PVK1_LAXSS
Sequence: GSTGLIPFGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, LaxSp-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: VP06_BPAPS
Sequence: MFHQAKSPTHSTLTNFLRTALILFPLFCGEYILTSGSMSNRTASSDKHPSIKPSAISNFARISPSSTRRRRAMARFE
What are the official names of this protein?
Putative protein p6.
Protein: YQGF_ALIFM
Sequence: MSSRTIMAFDFGTKSIGSAIGQEITGTASPLKAFKAQDGTPNWDDIEKQIKEWNPDLIVVGLPTDLHGKELDTITPRAKKFANRLHGRFGKQVELHDERLSTAEARADLFEFGGYKALSKGNIDCQSAVVILESWFENQWS
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_STAAN
Sequence: MKITILAVGKLKEKYWKQAIAEYEKRLGPYTKIDIIEVPDEKAPENMSDKEIEQVKEKEGQRILAKIKPQSTVITLEIQGKMLSSEGLAQELNQRMTQGQSDFVFVIGGSNGLHKDVLQRSNYALSFSKMTFPHQMMRVVLIEQVYRAFKIMRGEAYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XCT_ORYSJ
Sequence: MSGFGDGYVGTAQDAVKIRRLEKQREAERRKIEELKNKSSDGQPGLLQFGSSTSEILETAFKKETVGLVTREQYVEKRVNIRTKIEEEEKEKLQKLQQEEEELQMQKRKKRRVRGDPRLSFCDEIENGSDEDEFENQEPQKKHGPVKLGKDPTVETSFLPDREREAEEQAERERLKKQWSREQELIKNEPLTITYSYWDGTGHRRVIQVRKGDSIGEFLRAVQQQLAPEFREVRTTSVENLLYVKEDLIIPHQHSFYELIINKARGKSGPLFHFDVHEDVRTIADATKEKDESHAGKVVERHWYEKNKHIFPASRWEIYDPTKKWERYTIHGD
What is the function of this protein?
Involved in light regulation of the circadian clock and photomorphogenesis.
What are the official names of this protein?
Protein XAP5 CIRCADIAN TIMEKEEPER.
What is the protein family that this protein belongs to?
Belongs to the FAM50 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMA_MYCPU
Sequence: MSKIVIGLSGGVDSSVAAYLLKQQGHEVIGLFMRNWDSLVNSDILGNSSLNQSLCPQEQDFQDASRVAKQIGIPIYRVDFIKEYWDSVFENLIEQYQNGFTPNPDILCNKYIKFDKFFNYAIEKFGADYVAMGHYAIAKEGNLYRGIDQSKDQSYFLTQVRSQVLEKVIFPLGNMEKSEVRRIAQEANLYTANKKDSTGICFIGERKFTDFLQNYIPTQPGTIVDITTKKIVGNHIGAMYYTLGQRKGLNLGGMKEPYFVVGHDLEKKQVFVAPASEKKWLTSNWLFAQNLNLNNHDFNPENLSAKFRYRQKDVRVKVEFLENDQIKVYYPEGFEAVTPGQQIALYDGQKCLGGAVIKNIYWNENELNYSV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WTPC_ARCFU
Sequence: MFLKVRAEKRLGNFRLNVDFEMGRDYCVLLGPTGAGKSVFLELIAGIVKPDRGEVRLNGADITPLPPERRGIGFVPQDYALFPHLSVYRNIAYGLRNVERVERDRRVREMAEKLGIAHLLDRKPARLSGGERQRVALARALVIQPRLLLLDEPLSAVDLKTKGVLMEELRFVQREFDVPILHVTHDLIEAAMLADEVAVMLNGRIVEKGKLKELFSAKNGEVAEFLSARNLLLKVSKILD
What is the function of this protein?
Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import.  Responsible for energy coupling to the transport system (Probable).
What are the official names of this protein?
Molybdate/tungstate import ATP-binding protein WtpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GLNB_RHIEC
Sequence: MKIVMAIIKPFKLDEVREALTAIGIQGLTVTEVKGYGRQKGHTEIYRGTEYAVSFLPKLKIEIAVASELVDRAVEAIAASAKTGQIGDGKIFVYSIDHAVRIRTGETDSEAL
What is the function of this protein?
In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP.  P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.  Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS.  P-II indirectly controls the transcription of the GS gene (glnA).  P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA.  When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity).
What are the official names of this protein?
Nitrogen regulatory protein P-II.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: MRAY_LEGPL
Sequence: MLYWLTQLLQGQYHAFRVFQYLTFRSILASLTALIVGLLCGPLMIRWLRGLQIGQMVRSDGPQTHLSKAGTPTMGGVLILLAITVSCLLWCDLRQTSLWLVLLVTLANGLVGWVDDYRKLVLKNSKGLPGRWKYFWQSVIALVAVSYLYWNASLPVHTQLTAPFFKTVTWDLGIFFPVLAYFVIVGSSNAVNLTDGLDGLAIMPIVMVAGALGVFAYASSNAVYSNYLGIPYVPNTGELTIFCSSIVGAGLGFLWYNSYPAQVFMGDVGSLALGAALGIVAVVVRQELVLLIMGGLFVIETLSVILQVGYFKYSGGKRLFRMAPLHHHFELKGWSEPKVIVRFWIITVVFVLCGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRMB_LEUCK
Sequence: MHLRAKPWATDWLAAHSDIVITQGRATEQIGQWQKLFAKAQPIHVEIGSGKGQFILGMALAHPEINYIGMEIQETAVAIAARKSFDQVGELPNLRYIYGNGNGVETYFEKAEVEKIYLNFSDPWPKTRHESRRLTYKTFLQSYEAVLPEHGEVEFKTDNRHLFEYSIVSFMNYGMRWATTDFTLDLHADAEKVIGNVETEYEQKFMAKGQPIYKIKAHF
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: TYPH_ECOLC
Sequence: MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEAAKAVKAAIKLADKAPESTPTVYRRISE
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: YBEY_RALSO
Sequence: MLALRPEHHDSITLRIEAEPAAEAEDADDALAGAEMLTLDLTVQHGDALKAAARKALPKQKDIEAWIAPALFADAQLNVRFVDEEEGRTLNHTYRGKDYATNVLTFSYAETEDDPVAADIVLCCPVVEQEAKDQGKPLRAHYAHLIVHGALHAQGYDHEDPAQAEEMEGIETEVLAGLGFPDPYADR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_STRCO
Sequence: MTETPQRTRPLRVLAAMSGGVDSAVAAARAAEAGHDVTGVHLALSANPQSFRTGARGCCTIEDSRDARRAADVIGIPFYVWDLADRFREDVVEDFVAEYEAGRTPNPCLRCNEKIKFAALLDKALALGFDAVCTGHYAQVILREDGVRELHRASDMAKDQSYVLGVLDDRQLAHAMFPLGDTVTTKDEIRAEAERRGLAVAKKPDSHDICFIADGNTQGFLADRLGKAEGDIVDEAGNRLGTHEGAYGYTIGQRKGLRIGTPAPDGKPRYVLDISPVNNTVTVGPAEALDVDALRAIKPRWCGAAPTGPGTYTAQLRAHGGETEVRAELVDGTLEVTFSEPVRGVAPGQAIVLYDGTRVVGSATIASTTRATAGAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_LISW6
Sequence: MKANDIRDLSTTEIQDQEKALKEELFNLRFQLATGQLENTARIREVRKAIARMKTIVRERELA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: FAF1_RAT
Sequence: MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSDFGGETMPGPTFDPASPPAPAPAPSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDSCTVGEIKQILENELQIPVPKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTVQEVKRNVYDLTSIPVRHQLWEGWPASATDDSMCLAESGLSYPCHRLTVGRRTSPVQTREQSEEQSTVVHMVSDSDGDDFEDASEFGVVDGEVFGMASSTMRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDANRARFLTMCNRHFGSVIAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFSAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPEEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEFKLLSTFPRRDVTQLDPNKSLLEVNLFPQETLFLLAKE
What is the function of this protein?
Ubiquitin-binding protein.  Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation.  Potentiates but cannot initiate FAS-induced apoptosis.
What are the official names of this protein?
FAS-associated factor 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS16_BRUO2
Sequence: MALKIRLARAGSKKRPYYHVVVADVRAPRDGRFIETVGSWNPVLPKDAERVKLDAERIQHWIAQGAQPTDRVLRFLDQAGIAKRPSRNNPTKGEPGKKAQERLALAKQAEEEAAAKAAEAAAAAAAPAEEAASE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: AT12A_RHIMB
Sequence: MGTEANSDVYSTAINGINEIGYPDKEKEEDLGLEVQKKKEKKQKKKKGKNVDDLKQELDLEDHKLSIEELEAKYETSLQGLTSARAAEILARDGPNTLTPPKGTPEIIKFLKQMIGGFSLLLWAGAILCWIAYGILYAQDHNTSRDNLYLGIVLAVVVILTGCFAYFQEAKSTNIMASFNQMIPQQAVVTRNGQKLEIPAKDLVVGDLVDVKGGDRIPADLRIIFAQGCKVDNSSLTGESEAQPRSSEFTHENPLETKNIAFYSTTCLEGTARGFVINTGDQTIIGRIASLASGVGNEKTPIAVEIEHFVHIVAGVAVSVGVLFFIIAICMGYSALNSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDDHIHIADTSEDQSHHSFEQTPETWNALCKIVSLCNRAEFKAGQDDVPIMKKVAVGDASETALLKFSEVITGNVMNIRSQNRKVCEIPFNSTNKFQLSIHETDDPQDQRLLLVMKGAPERILEKCSTIMIGGKELPLDESMKDSFQTAYMELGGLGERVLGFCHLYLPEEEYPSSYAFDIESMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIARSVGIISAGSETVDDIAKRLNIPVEQVNKREAKAAVVNGGELKDMSSEELDDILTNHAEIVFARTSPQQKLIIVEGCQRQNYVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMILLDDNFASIVTGVEEGRLIFDNIKKSIGYTLTKNVAELCPFLIYIIADIPLPIGTITILFIDLGTDIIPSVSFAYEKAERDIMNRKPRRKNVDRLVNQQLALYAYLQIGIIQSVGAFLNYFTVMAEQGFLPHTLVGIRIDWEKINNQDLEDSYGQEWTFSQRQFLEWTGYTAFFVSIVVEQLADLIIRKTRRNSVFQQGLFRNKFLLMGLASQVIIAAFLSYCPEMPYALKFTPLRAQYWFVAAPYALLIFVYDEIRKLFIRRYPGSWWDKNMYY
What is the function of this protein?
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane.  Responsible for potassium absorption in various tissues.
What are the official names of this protein?
Potassium-transporting ATPase alpha chain 2, Non-gastric H(+)/K(+) ATPase subunit alpha, Proton pump.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: THIC_BACCN
Sequence: MEQSVSAEQIELKSSLPGSKKVYVEGSREGMKVPMREIELSDTNGVPNSPIRVYDTSGPYTDPEYKVELEKGIPTPRRNWIIERGDVEEYEGREIKPEDDGVKAASNHTPVFPQMDRKPLRAKKGANVTQMHYARKGIITSEMEYVAIREGVEPEFVRKEIAEGRAILPANINHPEAEPMIIGRNFHVKVNANIGNSAVSSSIAEEVEKMTWATRWGADTIMDLSTGKNIHTTREWIIRNAPVPVGTVPIYQALEKVQGIAENLTWEVYRDTLIEQAEQGVDYFTIHAGVLLRYIPLTAKRMTGIVSRGGSIMAQWCLYHHKENFLYTHFEEICEIMKQYDVSFSLGDGLRPGSIADANDEAQFAELETLGELTKIAWKHDVQVMIEGPGHVPMHLIKENMEKEIDICQGAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVREGVITYKIAAHAADLAKGHKTAQQRDDALSKARFEFRWRDQFNLSLDPERAMEFHDETLPAEGAKTAHFCSMCGPKFCSMKISHDIREYAKENNLETTEAIEKGMKEKAKEFKEAGSHLYQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: PIT1_MELGA
Sequence: MTCQAFASSDNFVPLNSDSSPSLPLIMHHSAAECLPVSNHATSVVSTVPSVLSLIQTPKCSHLHFAMMTSGNVSAGLHYSVPSCHYGNQTSTYGVMTGIKPATPEMLSASLSQSRILQTCSMPHPNVVNGVSTLQSKSFSFSCSLTPCLYKFPEHALSASSCALGHSFTPMHQTLLSDDPTAADFKQEFRRKSKSVEEPVDMDSPEIRELEKFANEFKLRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENSQLSFKNACKLKSILSKWLEEAEQVGALYNEKVGVNERKRKRRTTISIAAKEALERHFGEQSKPSSQEIMRMAEGLNLEKEVVRVWFCNRRQREKRVKTSLHQNAFSSIIKEHHECR
What is the function of this protein?
Transcription factor that activates growth hormone and prolactin genes.  Specifically binds to the consensus sequence 5'-TAAAT-3'.
What are the official names of this protein?
Pituitary-specific positive transcription factor 1, PIT-1, Growth hormone factor 1, GHF-1.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MMPS5_MYCTU
Sequence: MIGTLKRAWIPLLILVVVAIAGFTVQRIRTFFGSEGILVTPKVFADDPEPFDPKVVEYEVSGSGSYVNINYLDLDAKPQRIDGAALPWSLTLKTTAPSAAPNILAQGDGTSITCRITVDGEVKDERTATGVDALTYCFVKSA
What is the function of this protein?
Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism.
What are the official names of this protein?
Siderophore export accessory protein MmpS5.
What is the protein family that this protein belongs to?
Belongs to the MmpS family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PYRE_BRASB
Sequence: MSKSASRARLLEIIRRRSFGRGEVTLASGRKSDFYFNLKPTMMDPEGATLLAELTYEALKDEGFDYIGGLEMGAVPLAGAIAQISWIKGHPIAAFFVRKKPKEHGAKLAIEGLTRDETLAGKRIVVVEDVTTTGGSAMKAVETLREAGANVSLVFTMVDREEGAAETFAAAGLPFRALYKAREFL
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: GBG13_MOUSE
Sequence: MEEWDVPQMKKEVESLKYQLAFKREMSSKTIPELLKWIEDGIPKDPFLNPDLMKNNPWVEKAKCTIL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
What are the official names of this protein?
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.
What is the protein family that this protein belongs to?
Belongs to the G protein gamma family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: RS27_METLZ
Sequence: MVKASRETRSKFLKVKCPDCENEQLVFEKATSVVECTVCGRILAEPTGGKAALKADIVATFE
What are the official names of this protein?
30S ribosomal protein S27e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS27 family.
Protein: RPOA_LACJO
Sequence: MIEFEKPNITVVDQEEAYGKFVVEPLERGFGTTLGNSLRRVLLTSIPGTALSYIQIDGVLHEFSTIPGVREDVTKIILNLKKLELKSLSDEEKIAEIDVTGPAIVTAADLKVDSDIEVLNPDQYICSIADGGHLHMNVAIKTGRGYVPASENKTDDMPIGVIPVDSLFSPIKKVNYQVESARVGKRDDYDKLTLEIWTDGSITPNDALSFAAKILVEHFKVFMSTDMDAQFDDVMVEKEDDKNEKKLEMTIEELDLSVRSYNCLKRAGINTVQELTDKSEADMMRVRNLGRKSLEEVKNKLADLGLSLRQDD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: VF124_ASFP4
Sequence: MNLEYVQVVQKFNQVLLELTKKVCTVVGGSKPTYWYHHIRRVCSECPSMPMSMIGPYLNVYKSQILTKDKNFFMNFDPAHNEYTFIIQKLKEAARNMPEDELEQYWVKLLFLLKSYIKCKPFIN
What are the official names of this protein?
Uncharacterized protein H124R, pH124R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus H124R family.
What are the subcellular locations of this protein?
Virion.
Protein: CAPPA_PYRAB
Sequence: MIPRIMSTQHPDNYSIPFFANSPVLGGEDEITEAFYAFNVLGADEQMWDFEGKEVDEFVVKKLLERYPSFFRKVILGKDVRLTPRVPNPTVEKAEAKLLLETLQGITRAADYARVFYGEDIAPIFEVILPMTTSLAEIERVHELYRKVVNLADERIYDTTVKEWIGEFYPKEIGIIPLFETKVALLKSAKIIGEYLERREPEYQRVFLARSDPAMNYGLISAVTYVKNALQEIWELEEETSIPIYPIVGVGGPPFRGGMRPDNVDNVLSEYPSVQTYTVQSSFKFDYPTKEVVKAVEKVKSTKRKEPYSLEVPDFITLYEVEYQRQVKILAPHIRRLATRIPDRRKRKLHIGLFGYSRNVGGLSLPRAIKFTASLYSIGVPPELLGLNALTDRQLDVVSEYYVNIYEDLEFAMRFFSFRVAEKAGLKELVERIKEFKPEIEEEYVAEAEIVFRGEGDIIKLAQMRGFLG
What is the function of this protein?
Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 2 family.
Protein: ENO_SHEB8
Sequence: MAKIINVIGREIMDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRYLGKGVLTAVANVNDLIRTALLGKDATAQAELDQIMIDLDGTENKDKLGANAILAVSLAAAKAAAAFKGIPLYAHIAELNGTPGQYSMPVPMMNILNGGEHADNNVDIQEFMVQPVGAKTFREALRMGAEIFHTLKKVLHDKGLSTSVGDEGGFAPNLASNADALAIIKEAVELAGYKLGSDVTLALDCAASEFYKDGKYDLAGEGKVFDSNGFSDFLKSLADQYPIVSIEDGLDESDWDGWAYQTQIMGDKIQLVGDDLFVTNTKILTRGIENGIANSILIKFNQIGSLTETLAAIRMAKEAGYTAVISHRSGETEDSTIADLAVGTAAGQIKTGSLCRSDRVAKYNQLLRIEEQLGEKAPYRGLKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.