PharMolix/UniProtQA huggingface dataset:
Protein: ANFY1_HUMAN
Sequence: MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS
What is the function of this protein?
Proposed effector of Rab5.  Binds to phosphatidylinositol 3-phosphate (PI(3)P).  Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes.  Involved in macropinocytosis; the function is dependent on Rab5-GTP.  Required for correct endosomal localization.  Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB.  Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner.  Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.
What are the official names of this protein?
Rabankyrin-5, Rank-5, Ankyrin repeat and FYVE domain-containing protein 1, Ankyrin repeats hooked to a zinc finger motif.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome. Note=Also associated with endosomal membranes. Localizes to macropinosomes.
Protein: RL13_YERPE
Sequence: MKTFTAKPETVKRDWYVVDASGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNAEKVAVTGNKRTDKIYYHHTGFVGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMYRKLKVYAGTEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: CH60_ORITS
Sequence: MSKQIVHGDQCRKKIIEGINVVANAVGITLGPKGRCVAIEQSYGPPKITKDGVSVAKAIQLKDKSLNVGAQFVISVASKTADVAGDGTTTATVIADAAVRELNKAEVAGIDIQEVRKGAEKAVEAVIADVRKNSSPVKNEEEIAQVATVSSNGDREIGEKIANAMKQVGQEGVITVEDSKNFNFEVEVVKGMRFDRGYISQYFATNREKMITEFENPYILLLDQKVSTVQPLVPVLEAVAHTGKPLVLIADDVDGEALTALILNNLKGSIKVVAVKAPGFGDRKKEMLEDIAILTNGEVITEQLGIKLEKVNDTSKLGTANRVIVTKDHTTIVHDKNNSDIEKKVNSRCEQIREAIKDTTSDYEKEKLQERLAKLRNGVAVLKVGGATEVEQKERKDRVEDALHATRAAVEEGIVPGGGVALFYASRVLDSLKFDNEDQRVGINIIKKVLEAPVRQIVKNAGGKEDVVVNELSKSTDKNRGFDARTMQYVDMIKAGIVDPTKVVRTALQDAFSVASLVIATSAMITDHEEDNNTGNRSGGGVGGGHHGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 58 kDa antigen, 60 kDa chaperonin, Chaperonin-60, Cpn60, Major antigen 58.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_RALPJ
Sequence: MTIADNKKAFFDYFIEERYEAGMALEGWEVKAIRANRAQIKEGYVVIRNAELFLIGAHISPLQSASTHVHPDPVRTRKLLLHAEEIKKLIGKVEQRGYTLVPLNLHYTRGRVKCEIGLAKGKKQFDKRETEKDRDWQREKARLMREKA
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PRS6A_MOUSE
Sequence: MQEMNLLPTPESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.  PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
What are the official names of this protein?
26S proteasome regulatory subunit 6A, 26S proteasome AAA-ATPase subunit RPT5, Proteasome 26S subunit ATPase 3, Tat-binding protein 1, TBP-1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in cytoplasmic bodies.
Protein: LSHB_HORSE
Sequence: METLQGLLLWMLLSVGGVWASRGPLRPLCRPINATLAAEKEACPICITFTTSICAGYCPSMVRVMPAALPAIPQPVCTYRELRFASIRLPGCPPGVDPMVSFPVALSCHCGPCQIKTTDCGVFRDQPLACAPQASSSSKDPPSQPLTSTSTPTPGASRRSSHPLPIKTS
What is the function of this protein?
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
What are the official names of this protein?
Lutropin/choriogonadotropin subunit beta, LSH-B/CG-B, Luteinizing hormone subunit beta, Lutropin/choriogonadotropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMN6_ACTSZ
Sequence: MKAGNGFTFKRFHINHDRCAMKVGTDGILLGAWADLANSRSILDLGTGSGLIALMLAQRSDEDVQIHGVERDPAAARQAQENFRASPWAHRLYLHFGDIADFAQKCGQKFDNIVANPPYFAQGVDCRNHARNAARYTAALSHAQWLEIASSLLTEQGTIHFVLPAEQGKTLKQSTALYCVRQCDVISKQGKAAQRVLLSFMKEKKETAYSELTIYDEKNRYTLEFIQLTREFYLKF
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPQV_MYCTU
Sequence: MRPSRYAPLLCAMVLALAWLSAVAGCSRGGSSKAGRSSSVAGTLPAGVVGVSPAGVTTRVDAPAESTEEEYYQACHAARLWMDAQPGSGESLIEPYLAVVQASPSGVAGSWHIRWAALTPARQAAVIVAARAAANAECG
What are the official names of this protein?
Putative lipoprotein LpqV.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: MTP_MOUSE
Sequence: MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKPQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKGCPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFATHPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEMAVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAGVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF
What is the function of this protein?
Critical for the development of natural killer T (NKT) cells (PubMed:17312007).  Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:17635917).
What are the official names of this protein?
Microsomal triglyceride transfer protein large subunit.
What are the subcellular locations of this protein?
Endoplasmic reticulum. SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum. Golgi apparatus. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (By similarity). SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum. Golgi apparatus.
Protein: SOMA_HYPNO
Sequence: MARALVLLSVVLVSLLVNQGTASENQRLFNNAVIRVQHLHQLAAKMINDFEDNLLPEERRQLSKIFPLSFCNSDSIEAPTGKDETQKSSMLKLLRISFRLIESWEFPSQTLSGAVSNSLTVGNPNQITEKLADLKVGISVLIKGCLDGQPNMDDNDSLPLPFEDFYLTMGESSLRESFRLLACFKKDMHKVETYLRVANCRRSLDSNCTL
What is the function of this protein?
Growth hormone plays an important role in growth control.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PCP_STAAT
Sequence: MHILVTGFAPFDNQNINPSWEAVTQLEDIIGTHTIDKLKLPTSFKKVDNIINKTLASNHYDVVLAIGQAGGRNAITPERVAINIDDARIPDNDDFQPIDQAIHLDGAPAYFSNLPVKAMTQSIINQGLPGALSNSAGTFVCNHTLYHLGYLQDKHYPHLRFGFIHVPYIPEQVIGKPDTPSMPLEKIVAGLTAAIEAISNDEDLHLALGTTE
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_ECO45
Sequence: MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQEALKESGLTAKDIDAVAYTAGPGLVGALLVGATVGRSLAFAWDVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVSGGHTQLISVTGIGQYELLGESIDDAAGEAFDKTAKLLGLDYPGGPLLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRDNGTDDQTRADIARAFEDAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTDNGAMIAYAGMVRFKAGATADLGVSVRPRWPLAELPAA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_STREM
Sequence: MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHVPNPSYEQVCSKTTGHTEAVEIIFDPSLISYSDLVELYWAQTDPTDAFGQFEDRGDNYRPVIYYTDERQREIAERSKQSLQASGRFDQPIVTSIEPAEPFYLAEDYHQGFYQKNPQRYAQSSAIRHQFLEEHWQ
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: RL27_HALH5
Sequence: MLKMNLQFFASKKGVGSTKNGRDSISKRLGTKRADGQLVTGGSILVRQRGTRIYPGVNVGKGGDDTLFAKVDGVVKFERVGRDRKQVSVYPKAQ
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: FSLB_DICDI
Sequence: MFNKNNNNNKIIIILKLFLIILIVNNNNNIKTFGLNLPDGYGAGLVDPTATCSNYIGDSIDQPLCNEKLPNYKNIYTSKNITIQYINQKIVEKTFISLTFLQSKCFDLNFAEFGICDIYFPPCFQTPTTITPIKSVSLPQRLCKSACERMVSNCSSLGASLNCSDPLKFPRIATLYNLTDYGFTANGGFFPVPCSDPLATFENKSTTSELIEICPSPLLLFNSSDPKYSADRGYTYLTPTNCVLPCVAPIYTEKKWHQMYNMSKILSTISFVCSIYNVLTFGILNHRRSKYNYCITFFSASVIIITMMDIVTYGIGYEKLLCPEPGRFAVQSDVSCGATGALFHIGITNGVFWWTTMSICLFAVVKRIKLFDFRYFIIFNTTASLISVIIPLAGNAFMAGTGSLACWIRKTWYVNSVFWIPCGIALTIGSVCIILVIYEIYKITKNVSTKDNRMILLQIKPFLCVTLVGGSFYYLFIFNFDNESHSKEYKEKVVDYVMCLLSDTGKECLMAGPNYVAYFVFYFFIRLFGITFFCIYGTSQNARDIWIHSKILNHPNIKPFLLKYNIINFNSMTHYGSGTNPTSNSKNSKNNQNNQNNNSRKEFESKNIELEVNESISKGQTTRGADDEEESNINSASNTSSD
What are the official names of this protein?
Frizzled and smoothened-like protein B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RUVA_BORPA
Sequence: MIGRITGTLIEKSPPVVCVDVNGVGYEIDVPMSTLYALPETGARVTLFTHLVVREDAQLLYGFGSSAERSTFRELIKVTGIGARTALAVLSGLSVAELSQAITLQETGRLTRVPGIGKKTAERLLLEMRGKLGADIGATPHAAGGHQSDILNALLALGYSDKESQAALKKLPEGVDVSEGIRLALKALVR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: LEPA_PARMW
Sequence: MTDAPVSRIRNFCIIAHIDHGKSTLADRLLQDTGTVANRDMQEQFLDNMDLERERGITIKLQAARMNYTATDGQQYVLNLIDTPGHVDFSYEVSRSLQACEGALLVVDASQGVEAQTLANVYLALDNDLEIIPVLNKIDLPGADPDRIKEEVEAIIGLDCDNAIPCSAKTGLGVPEILQAVVDRVPPPKDALEEPTKALIFDSYYDPYRGVIVYFRVMSGRISCKDKVLLMASKKTYELDEIGIMAPDQKKVDELHAGEVGYLAASIKAVADARVGDTITLLSAPADEALPGYTEAKPMVFCGLFPTEADQYPDLRDALDKLQLSDAALKYEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYDLDLIVTAPSVIYKVNMIDGSEVMVDNPATLPDPQKRESIEEPYVKMEIYAPNEYNGALMGLCQERRGEYIDMKYITTDRVTLIYELPLAEVVTDFFDQMKTRTQGYASMEYSLIGYRKNQLVRLDVLINGERADALTTIVHQDKAYNVGKALVEKLKELIPRQQFKIPIQASIGSRIIASTSISAIRKDVLAKCYGGDISRKKKLLKKQAKGKKRMKAMGKVDVPQEAFMAVLKLNDGGGS
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RN133_RAT
Sequence: MNPLQTGPWQTSAPSFWLLKFSFIWLVSQNCCTASAVWTAYMNISFHVGNRMLSELGETGVFGRSSILKRVAGVVVPPEGKIQNACDPNTSFILPRNKEPWIALIERGGCAFTQKIKVASENGARGVIIYNFPGTGNQVFPMSHQAFEDIVVVMIGNVKGMEILHLIRKGVHVTVMVEVGRKHVIWLNHYFVSFMIVTTATLAYFTFYHIRRLWVARIEDRRWKRLTRELKKAFGQLQVRILKEGDEEVSPNADSCVICFEAYKPNEIVRILTCKHFFHKNCIDPWILAHGTCPMCKCDILKALGIQMDIEDGSDSLQVLMSNELPGTFSAMEEELNNELPPARTSSKVTHVQEHPTSVNVGSQPPEAEETGHPSFGQHDL
What is the function of this protein?
Has E3 ubiquitin-protein ligase activity.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF133, RING finger protein 133, RING-type E3 ubiquitin transferase RNF133.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: DDL_HAEIG
Sequence: MNLKQEKIAVLLGGTSAEREVSFNSGRAVLEALLKQGYNAHPIDPKEYNVANLKKDGFNRAFNILHGRGGEDGTMQGLLEQIGLPYTGCGVMASALTMDKMRTKMLWKAFGLPVADMKVVTRETFSELDPQAVVAKLGLPLMVKPSLEGSSVGLTKVKAVEELKSAVEYALKFDNTILIEEWLAGDELTVPVLDNQVLPAIRIVPEGEFYDYEAKYISDNTQYFCPAGLTPEREQELAILVKRAYDAVGCRGWSRIDVMCDAKGNFRLVEVNTNPGMTSHSLFPKSAATVGISFEQLVVKILELSL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_STRPG
Sequence: MTQMTVQVVTPDGIKYDHHAKCISVTTPDGEMGILPNHINLIAPLQVHEMKIRRGGEDEKVDWIAINGGIIEIKDNVVTIVADSAERDRDIDVSRAERAKLRAEREIAQAETTHNIDEVRRAKVALRRALNRINVSKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LTAE_ECO57
Sequence: MIDLRSDTVTRPSRAMLEAMMAAPVGDDVYGDDPTVNALQDYAAELSGKEAAIFLPTGTQANLVALLSHCERGEEYIVGQAAHNYLFEAGGAAVLGSIQPQPIDAAADGTLPLDKVAMKIKPDDIHFARTKLLSLENTHNGKVLPREYLKDAWEFTRERNLALHVDGARIFNAVVAYGSELKELTQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRAIRWRKMTGGGMRQSGILAAAGMYALKNNVARLQEDHDNAAWMAEQLREAGADVMRQDTNMLFVRVGEENAAALGEYMKARNVLINASPIVRLVTHLDVSREQLAEVAAHWRAFLAR
What is the function of this protein?
Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.  L-threo-phenylserine and L-erythro-phenylserine are also good substrates (By similarity).
What are the official names of this protein?
Low specificity L-threonine aldolase, Low-specificity L-TA.
What is the protein family that this protein belongs to?
Belongs to the threonine aldolase family.
Protein: YDZJ_BACSU
Sequence: MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLGSLALHLIH
What are the official names of this protein?
Uncharacterized membrane protein YdzJ.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: LYSY_IGNH4
Sequence: MTYEVAIVGASGYTGGELLRVLAVHPDVNVKVVTSREYANKPVYYAHPHLRGIYPASLKFKRLDDPDQLSDVVGDVDLVFLALPHKVSLHYVPKALEVGYKVVDLSADYRLKRVEDYKTWYGYEHPYPDLLEKAVYGLPELYGDKIRGAQLVANPGCNATSSILAVLPPAAERIIDLDRIVVDVKVGSSEAGAKPYRGGHHPEREGTARPYDAEGHRHVAELEQVIRDYTGRDVKVGFTPHAVSMIRGSLASAYSWLTKDLAPLDVQRIYAKYYAGKKFVKIVRGAPMPYPDVKNVYGSNYAEVGFALDKRVGRLAMFAAIDNLMKGAAGTAVQNMNLMLGMDEDEGLKNLVPVRP
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.
What are the official names of this protein?
Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMJ_ECOLI
Sequence: MLSYRHSFHAGNHADVLKHTVQSLIIESLKEKDKPFLYLDTHAGAGRYQLGSEHAERTGEYLEGIARIWQQDDLPAELEAYINVVKHFNRSGQLRYYPGSPLIARLLLREQDSLQLTELHPSDYPLLRSEFQKDSRARVEKADGFQQLKAKLPPVSRRGLILIDPPYEMKTDYQAVVSGIAEGYKRFATGIYALWYPVVLRQQIKRMIHDLEATGIRKILQIELAVLPDSDRRGMTASGMIVINPPWKLEQQMNNVLPWLHSKLVPAGTGHATVSWIVPE
What is the function of this protein?
Specifically methylates the adenine in position 2030 of 23S rRNA.  Nascent 23S rRNA seems to be the natural substrate.  Appears to be not necessary for ribosome assembly.  Required for the utilization of extracellular DNA as the sole source of carbon and energy (PubMed:11591672, PubMed:16707682).
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase J, 23S rRNA (adenine(2030)-N6)-methyltransferase, 23S rRNA m6A2030 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RlmJ family.
Protein: CRCB_METJA
Sequence: MIRELLLIGVGGFFGAIFRYLISGIVPVKFGLPTGTLAVNLIGSFILGFLLYCSLFAPIPTEYKLFIGTGFCGALTTFSTFSYETFVLVDEGLLFKALLNILINVVGCLIMVYFGRVLALAIFR
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OLIG2_HUMAN
Sequence: MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGSLPRLTSDAK
What is the function of this protein?
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain.  Functions together with ZNF488 to promote oligodendrocyte differentiation.  Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube.  Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
What are the official names of this protein?
Oligodendrocyte transcription factor 2, Oligo2, Class B basic helix-loop-helix protein 1, bHLHb1, Class E basic helix-loop-helix protein 19, bHLHe19, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.