PharMolix/UniProtQA huggingface dataset:
Protein: FTSN_ECOLI
Sequence: MAQRDYVRRSQPAPSRRKKSTSRKKQRNLPAVSPAMVAIAAAVLVTFIGGLYFITHHKKEESETLQSQKVTGNGLPPKPEERWRYIKELESRQPGVRAPTEPSAGGEVKTPEQLTPEQRQLLEQMQADMRQQPTQLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASSQQPYQDLLQTPAHTTAQSKPQQAAPVARAADAPKPTAEKKDERRWMVQCGSFRGAEQAETVRAQLAFEGFDSKITTNNGWNRVVIGPVKGKENADSTLNRLKMAGHTNCIRLAAGG
What is the function of this protein?
Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell.  Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm.  These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases (Probable) (PubMed:25496160).  Required for full FtsI activity (PubMed:25496160).  Required for recruitment of AmiC to the septal ring (PubMed:12787347).
What are the official names of this protein?
Cell division protein FtsN.
What is the protein family that this protein belongs to?
Belongs to the FtsN family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the septum (PubMed:9282742, PubMed:19684127, PubMed:24750258). Localizes to the midcell via interaction with the early cell division protein FtsA and via the periplasmic SPOR domain (PubMed:9282742, PubMed:19684127, PubMed:24750258). FtsA-dependent localization precedes SPOR-dependent localization, and both are needed for efficient localization (PubMed:24750258). Localization depends upon FtsZ, FtsA, ZipA, FtsQ and FtsI (PubMed:9282742, PubMed:11948172).
Protein: KLD10_XENLA
Sequence: MAAEAGGGEPLVKFVKLSGRAAGSKKKVRWFPVRRLFTHSCPSLRIPSRFLREGRRSPPARSGHRCVADNTNLYVFGGYNPDYDESGGPENEDYPLFRELWRYHFATGMWHQMGTDGHMPRELASMSLVLHGHNLLVFGGTGIPFGESNGNDVYVCNVRYKRWSKLNCRGKKPNRIYGQAMAIIHGFLYVFGGTTGYIYSTDLHRLDLSTREWIQLRPNNPPCDLPEERYRHEIAHDGQRIYVLGGGTSWTAYSLEKIHAYNFETNTWEDIPTKPHGNLGFPAARRCHSCVQIKNEVFICGGYNGLVILGDLWKLNLQTFQWTKLPALMPEPAYFHCAAVTPAGCMYIHGGVVNIQQNKRTGSLFKIWLTVPSLLELCWENLLKYFPQLCQLPTHQLLQLGLSQELIERLK
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) at the C-terminus, leading to their ubiquitination and degradation.  Participates in the oxidative stress-induced cell death through MAP3K5 activation.
What are the official names of this protein?
Kelch domain-containing protein 10.
Protein: RHGT2_BACSU
Sequence: MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAIGGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQYIAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLAFFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER
What is the function of this protein?
May play a role in the degradation of rhamnogalacturonan derived from plant cell walls.  Probably has broad substrate specificity and may degrade several types of acetylated substrates.
What are the official names of this protein?
Probable rhamnogalacturonan acetylesterase YesY, RGAE.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
Protein: MRE11_THEVO
Sequence: MVRFLHMSDTHIGAKSLTIEEREQDYYDTFQEAVEIAIDEKVDFIIHSGDLFDTWIPGNRSMKVFRDAMMKLNDRQIPVFYVFGDHDRPRRNSESAAGIFDFLGLHILGRDEFAGIEREFSGMKVFIGGISNMKGYLRNQLKEEYKKAESASTGYKNSILISHQALDPIFIPEQCEAKVNDLPMNYSYIAMGHLHDFVEREIGPLLSYPGSTELKSDREINGLLKMGKGINVIDLDNGVASLHRVKLKKVRYQFKVESDPENYLEEIKSILDKYANAIGEKKPIVNLIINGQISMEEVYEDLKKINGAIFNRPQILKIVDMPNVPSGSSELREYFQAFLKDQKLTDLAMKVFQHTADGDKEAIIREAAGEAIDN
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair.  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA.  Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
What are the official names of this protein?
DNA double-strand break repair protein Mre11.
What is the protein family that this protein belongs to?
Belongs to the MRE11/RAD32 family.
Protein: PURA_GLUOX
Sequence: MSNVTVIGTQWGDEGKGKIVDWLASRADIVVRFQGGHNAGHTLVVGDQIYKLSLLPSGLVRGKIGVIGNGVVVDPKALMTEIDRVTAQGLVVTPETLWIAENAPLILPVHGALDRAREAARGDHKIGTTGRGIGPAYEDKVARRAIRICDLAEPETLDWKLDELLLHHNTLLAGLGAETFTKEQLKDFLAEITPRLLPFSCQVWDRLDEARRAGRRILFEGAQAVMLDVDHGTYPFVTSSNTVAAVAASGSGVSPSSVGFVLGIAKAYTTRVGEGPFPTELHDQTGRTLGERGHEFGTVTGRPRRCGWFDAVLIRRAVRVGGVSGIALTKLDVLDGLDEISICVGYELDGQKIETFPSAPGAQTRVKPVYETMPGWKETTAGARSWAELPAQAIKYVRRIEELIEAPVTLLSTSPERDDTILMRDPFED
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_BAUCH
Sequence: MDKFRIQGPTQLIGEVTIAGAKNSALPILFATLLAEEPVNIHNVPKLKDIDTAIQLISQLGAKVKYNKSVYVDASNIAVYCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHLDGLAKLGATITLEKGYVKAYIKGRLRGAHIVMDKVSVGATVTVMSAATLAQGITIIDNAALEPEIVDTANFLITLGANIIGAGSNQIIIDGVTSLGGGEYRVLPDRIETGTFLVAAAISRGHIVCHATRPNMLDAVIAKLRETGAKIETGEDWISLNIHGKRPKAITVRTAPYPGFPTDMQAQFSLLNLIAKGTSVITETIFENRFMHIPELMRMGVHAKIENNTIICHGVEKLSGAQVMATDLRASASLVLAGCIAEGVTIVDRIYHIDRGYDCIENKLRNLGANIERIYS
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_AZOPC
Sequence: MFEEKLSTDNNIRRIFIETYGCQMNIADSEIVIAIVQMDGFEYTENILEADVVLINTCSVRENAEKKIFSRLQYFQSLKKKRNQLIIGVLGCMAKRIRETLIQQYHVDLVVGPDSYMDLPHLIGTVEKGAKAININLSSTEVYKGIVPLKLSRIKISGFISIIRGCNNFCSYCIVPYTRGRERSRDPKSILNELHILKEQGYKEVILLGQNVNSYFYKNENITDFPHLLELVALNAPEMRIRFTTSHPKDMGDETLRVIAKYNNICKHIHLPIQSGSSKILRAMNRKYTREWYLQRVTSIRKIVPEVSISTDLFCGFPSETEEDHKKTLSLMKEVGFDSAFMFKYSERPETYASRYLPDNVPEEVKIRRLNEIITLQLKISLMKNKENIGKTMEILIEGFSKRSREQLFGRTLQNKIVLFPRKNYHIGEKVLVEIKKASAATLFGDPKL
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM33_DROME
Sequence: MRLTNVLFKKVKSKRIMVVLESVVSGHQFNAFRDRLADKLEIIRFDPYIQQESLYRERKKIRSA
What are the official names of this protein?
39S ribosomal protein L33, mitochondrial, L33mt, MRP-L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RRF_CUPNH
Sequence: MSVADTKKSVEQKMQKSIEAFKADLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVAAVGLADARTITVQPWEKKMVGAVEKAIRDCDLGLNPATMGEVIRVPMPALTEERRKELTKVVKGEAEGAKVAVRNLRRDANEQFKKLVKDKTISEDDERRGQDEVQKLTDKYVAEIDKMVAEKEKEIMTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYTR_STRA3
Sequence: MKILILDDEMFARQELSFLVEHSQEVDNPEIFQAEDISEAEKILFRQQIDLIFLDISLSEENGFTLANQLSQLAHPPLVVFATAYDNYAVKAFESNAVDYIMKPFEQQRVDMALSKVKKLSQLTTASDVEQAIPKKASVELLTLTLSDRSVVVKMQDIVAASVEDGELTVSTVQKTYTIRKTLNWFKSRAVAPYFLQIHRNTVINLEMIEEIQPWFNHTLLLIMSNGEKFPVGRSYLKDLNEHLTM
What is the function of this protein?
Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism.
What are the official names of this protein?
Sensory transduction protein LytR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIE_BORBU
Sequence: MVRTDAFFTENNINLVKKNPLHFDVNLFSSKSNAKDNDIKTFKDVLINSITDVNKSQLNVSKVTEQAILKPSSIDVHDVVIAMSKANMNLSILKAVVERGVKAYQDIINIR
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: KLH12_XENLA
Sequence: MAPKDIMTNSHAKSILNTMNSLRKSQTLCDVTLRVNLKDFPAHRIVLAACSDYFCAMFTNELSEKGKPYVDIQGLTSSTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCDFLESQLDPSNCLGIRDFAETHNCLELMQAAEVYSQKHFPEVVQHEEFMLLHQEEVEKLIHCDEIQINSEEPVFEAVINWVKHNRHEREKSLPQLLQYVRMPLLTPRYITDVIDAEPLIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRVRLGANEVLLVIGGFGSQQSPIDIVEKYDPKTQEWSVLPSITRKRRYVATVSLGDRVYVIGGYDGRSRLSSVECLDYTSEEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVANGVIYCLGGYDGLNILSSVERYDPHTGHWSHVTPMATKRSGAGVSLLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTMTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLNSVECYDPLIDSWAVVTSMATQRCDAGVCVLREK
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.  The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity).
What are the official names of this protein?
Kelch-like protein 12.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle.
Protein: GCST_SHEB8
Sequence: MANKTILFNKHLESNAKMVDFHGWDMPLNYGSQIEEHNAVRQDAGMFDVSHMTVVDVIGNDACAFLRKLLANDVAKLKVPGKALYGGMLDENAGVIDDLITYYLTDTNYRVVVNSATREKDLAWIAKQSQGFDVTVTERPELAMIAVQGPNAKAKAAAVFSSDQNAAIEGMKPFFGKQAGSLFIATTGYTGEAGYEIIVPEDEAQAMWQALLDQGVKPCGLGARDTLRLEAGMNLYGLDMDETINPLAANMGWTIAWEPSDRDFIGRKALETLRDAGTDKLVGLVMEEKGVLRHDMPVFFTDSAGVEHQGVITSGTFSPTLGYSIAMARVPNSIGDTAEVEMRKKRVAVRVVAPNFVRNGKQAF
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MEP8_COCP7
Sequence: MKLSSILLALAALVSPAFSYAISHLPRSEGGLDIKLTAIGNTRIKAIITNKADRPLKLLRYNNFFDDAPTQKVEIFKDGNAVQFEGIYQHIYMTDLPDEDFISLTPGESIEREVDIATTADLTQGGAFTISSQGLIPFAEVDSNEVTGAMAFHANDLEMDVDGAVAATVEKAIKPVDKRSRLTNSCTGQRRTATVRAIQASAQLSQRSAQVAQNNAQKLQEYFKQTDQRTRQLVVNRFTAVARESTVNGGRTTYDCTDRMGHCQPRTIAYTLPAQNHITNCPIFYQMPLLTNRCHGQDQATTVLHEITHNPAIVQPHCVDHGYGYQAVRRLNAQQSLQNADTYSLFANGKMTFRLFLY
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Shows high activities on basic nuclear substrates such as histone and protamine.  May be involved in virulence (By similarity).
What are the official names of this protein?
Neutral protease 2 homolog MEP8, Deuterolysin MEP8, Metalloproteinase 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PPID_RAT
Sequence: MSHPSPAGKPSNSKNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGTGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGQVIKGLGVARMLENVEVNGEKPAKLCVIAECGELKEGDEWGIFPKDGSGDSHPDFPEDADIDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYAKVLRYLDSSKAVIEKADVSRLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALEMDPSNTKALYRKAQGWQGLKEYDQALADLKKAQEIAPGDKAIQAELLKVKQMIKAQKDKEKAVYAKMFA
What is the function of this protein?
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.  Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes.  Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control.  May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes.  May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus.  May regulate MYB by inhibiting its DNA-binding activity.  Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region.  Involved in regulation of UV radiation-induced apoptosis.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase D, PPIase D, 40 kDa peptidyl-prolyl cis-trans isomerase, Cyclophilin-40, CYP-40, Rotamase D.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: ENTC3_STAAN
Sequence: MYKRLFISRVILIFALILVISTPNVLAESQPDPMPDDLHKSSEFTGTMGNMKYLYDDHYVSATKVKSVDKFLAHDLIYNISDKKLKNYDKVKTELLNEDLAKKYKDEVVDVYGSNYYVNCYFSSKDNVGKVTGGKTCMYGGITKHEGNHFDNGNLQNVLVRVYENKRNTISFEVQTDKKSVTAQELDIKARNFLINKKNLYEFNSSPYETGYIKFIENNGNTFWYDMMPAPGDKFDQSKYLMMYNDNKTVDSKSVKIEVHLTTKNG
What is the function of this protein?
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules.  In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines (By similarity).  Causes also the intoxication staphylococcal food poisoning syndrome (By similarity).
What are the official names of this protein?
Enterotoxin type C-3, SEC3.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MBL_CAEEL
Sequence: MFDENSNAAGTTPVASSLAATPNANLVSQVFNVKDSRWLQVEVCREFLRGQCARSDQECKFAHPPPNVDVQQGRVTACYDSIKGRCTRENPKCKYLHPPQHIKDQLLINGRNHLALKNLLSAQLNQTGTPMVNPMMALQQQAAAVNLIPNTPIYPPYYNGMMYPQVLQDPYTAAAVNQVLDSNQEYHSPPTDKKNQQLQTAALLGNVGGLLSAQSAAAFMANSSAAAAAAQQTPSPLLRLQRKRALEEENTNGNDMTSAAAAHTQLLSLAAGAVPMKRPTLDKNGAMLYSPVAQQAQQFNPYLLQTLQGYVPAVSCEYMQPPPF
What is the function of this protein?
Binds to RNA with repeat sequences 5'-CUG-3' and 5'-CCUG-3'.
What are the official names of this protein?
Muscleblind-like protein, CeMBL.
What is the protein family that this protein belongs to?
Belongs to the muscleblind family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LCMT1_CRYNJ
Sequence: MTQCGDRRLLALIIYHGAIQTPPPTDPNAAPAHRPAPRPALGRCRPPHRRRRRLRPPVRPPVSLPVALTTRSSAAQLGYLQDPFASLLYRPPMPQPGAFAPQAVGRARKPPLINVGTHHRTWGIDRLVDRFLQRGGKQVVSLGAGSDTRFWRLMSRATPPDLARYVEIDFPHLTSPKAQRIARHRKLYQYLGPSSTAMPPPGHPYTVSKGGTQLSSPLYTLLPLDLRPSPSEPASSISAILSHHVLPQLDPRLPTLFLAECLFPYMSPEDSREIIKWFGETFCSCMGVVYEMVGLDDSFGNVMKRNLAVRNLSIPGSIFSTPESQAGRFTSPMLQGGKFDSAGAKTLWQIREEDVGPEELQRISKLEILDEIEELRLVLEHYVIAWGTKGECMSSISL
What is the function of this protein?
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
What are the official names of this protein?
Leucine carboxyl methyltransferase 1, Protein phosphatase methyltransferase 1, [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.
Protein: LSPA_CHLL2
Sequence: MKWFFTFASVVVLLDQFTKKLAVLFLRDRGTVTIIPDWLKLTYAENNGIAFGVEFASQAIMILLVGSISLMIALYVLKSGNRKTLFLLPFSLIFGGGIGNLIDRLTVGRVIDFIHFDLYQGTIMGSWVSLWPIFNVADSAITIGACMLILLHNRIFPEPDTKAENHVR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BIOH_PSEA6
Sequence: MHTTLKTRTVGSGPNFVLLHGWGVNSGVWQPIAKQLEQHFSVTYVDLPGFGENNQIMPKPYDLKNLAECVANVLPENSVLAGWSLGGLVAQHVALLEPTNVKQLILIATSPKFQKGNDWAGIDPNILQAFSQQLVKNLSKTIERFLAIQAMGSDSAKTDIRKIKNSIEASPQADIAALTAGLDILEHVDLRDQIAALKMPIHWMLGRLDSLVPVKLQGYVQRSLAKNHSVTIFPHASHAPFISHTEDFLIDLMENTLR
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PORED_DANRE
Sequence: MFHILSIVNIIWLLLALCFGAAFCLNKFSVKLPNRVEHVFQDFIRYGKTKENIKRASWQLVFDLSKRYFYHFYVVSVMWNGLLLLFSIRSVVMSEAFPDWIIDVLGSLTGRSRGAWNEIHLSTLLLQVLLWVHTLRRLLECLFVSVFSDGVINVVQYAFGLSYYIILGLTVLCTNDSLPQSESVSFFNQLTWYHVVGTLLFFWASFLQHQSLSLLAKMRTDSSGKVETLAHKMPCGGWFELVSCPHYLAELLIYAAMCVCCGCASLTWWMVVLYVLCNQALAAQLCHEYYRSKFKTYPHHRKAFIPFVL
What is the function of this protein?
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol.  Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.  Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.  Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
What are the official names of this protein?
Polyprenol reductase, 3-oxo-5-alpha-steroid 4-dehydrogenase 3, Steroid 5-alpha-reductase 3, S5AR 3, SR type 3.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TILS_THET2
Sequence: MDVPAFRERLLRLAPKDPLVLAVSGGGDSVALALLVKEAGRQAVVAHLDHGLRPESPLDQAFVRALAERLGFPFFTERVEVARIAQARGENLEAVAREVRYAFLHRVAREVGARAILTAHTLDDQAETVLLQLLQGTARATGIREREGIVVRPLLAHTREELRAYLRARGEAWREDPTNQDPALDRNFLRLFVFPLLEERFPAAKRALARFAEARAEEEGVLERQAEARLLPDPRFFVPAFRAAPLLEAPLAVRRRALRRLLEKLGLRPEARLVLLLEEALRGRPQTLPGGVLARRKGGTLFLLPPRPRLPLPPGFRRPAPGDYLERPSGRKRLVDFLAEKGVPRELKPLWPVRAEGSRVVEVLGLYPPPPEEAHMAEALAEAASAFREGEVPVGAVLVLPGRVLRAHNRVEGLRDPTAHAEMLLLREAGPEARGGRLYVTLEPCLMCHHALAQAGVEVVYGAENLKEGALTRFGLPTRARGGVRERECAKLLRDFFARLREGCRSG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity).
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_VIBVY
Sequence: MKAGIHPEYKAVNATCSCGNSFVFNSTLDKDSIHLDVCDKCHPFYTGKQRIVDTGGRVDRFNKRFGALSSGKK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: NAGZ_KLEP3
Sequence: MGPVMLDVEGYELDAEEREILAHPLVGGLILFTRNYHDPAQLRELVRQIRDASRNHLVVAVDQEGGRVQRFREGFTRLPAAQSFAALLGMEEGGKLAAEAGWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHEDPQKALTMARHFIDGMHAAGMKTTGKHFPGHGAVTADSHKETPFDPRPASVIRDHDMAVFKSLIAEQRLDAIMPAHVIYPELDPRPASGSAYWLKTVLRGELGFDGVIFSDDLSMEGAAIMGSYAERGQASLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTKLYHKGSFSRQELRDSARWKTVSAQLEQLHARWQEAKSA
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE23_HELP2
Sequence: MKLTPKELDKLMLHYAGELAKKRKEKGIKLNYVEAVALISAHIMEEARAGKKTAAELMQEGRTLLKPDDVMDGVASMIHEVGIEAMFPDGTKLVTVHTPIEANGKLVPGELFLKNEDITINEGKKAVSVKVKNVGDRPVQIGSHFHFFEVNRCLDFDREKTFGKRLDIASGTAVRFEPGEEKSVELIDIGGNRRIFGFNALVDRQADNESKKIALHRAKERGFHGAKSDDNYVKTIKE
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THNS2_HUMAN
Sequence: MWYVSTRGVAPRVNFEGALFSGYAPDGGLFMPEELPQLDRGTLCQWSTLSYPGLVKELCALFIGSELLPKDELNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLSCTTQFLQYFLEKREKHVTVVVGTSGDTGSAAIESVQGAKNMDIIVLLPKGHCTKIQELQMTTVLKQNVHVFGVEGNSDELDEPIKTVFADVAFVKKHNLMSLNSINWSRVLVQMAHHFFAYFQCTPSLDTHPLPLVEVVVPTGAAGNLAAGYIAQKIGLPIRLVVAVNRNDIIHRTVQQGDFSLSEAVKSTLASAMDIQVPYNMERVFWLLSGSDSQVTRALMEQFERTQSVNLPKELHSKLSEAVTSVSVSDEAITQTMGRCWDENQYLLCPHSAVAVNYHYQQIDRQQPSTPRCCLAPASAAKFPEAVLAAGLTPETPAEIVALEHKETRCTLMRRGDNWMLMLRDTIEDLSRQWRSHALNTSQ
What is the function of this protein?
Potent inducer of osteoblastic production of IL6.  May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.
What are the official names of this protein?
Threonine synthase-like 2, TSH2, Secreted osteoclastogenic factor of activated T-cells, SOFAT.
What is the protein family that this protein belongs to?
Belongs to the threonine synthase family.
What are the subcellular locations of this protein?
[Isoform SOFAT]: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.