PharMolix/UniProtQA huggingface dataset:
Protein: GSA_BORBR
Sequence: MSTNAELFDRACRSIPGGVNSPVRAFRSVGGTPRFIQRAQGPYVWDAEGKQYIDYVGSWGPAILGHAHPEVVRAVQEAAVHGLSFGAPTEAEVELAEMLIARLPSLEQVRLVSSGTEATMTAIRLARGATGRHKIIKFEGCYHGHSDSLLVKAGSGLLTFGNPSSAGVPPEFVAHTLTLEFNNLAAVDAAFSQHGAEIACVIVEPVAGNMNLIKPAEGFLAGLRELCTRHGAVLIFDEVMTGFRVGPQGVQGLTGVRPDLTTLAKVIGGGMPVGAFGGRADLMAHIAPLGGVYQAGTLSGNPVAVAAGLATMRLIGEPGFYERLSAQTARLAQGLQERARAAGVPFSADAIGGMFGLYFGDRVPASFAEVSACDTEAFKRFFHAMLERGIHFAPSAFEAGFVSATHDDAVIDATLEAAEQVFATLRA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UIMC1_HUMAN
Sequence: MPRRKKKVKEVSESRNLEKKDVETTSSVSVKRKRRLEDAFIVISDSDGEEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAREVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTEKTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYFWGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRASDWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFDLEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTVLTRRQKEAKTKSDSGTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKTSDADIKSSETGAFRVPSPGMEEAGCSREMQSSFTRRDLNESPVKSFVSISEATDCLVDFKKQVTVQPGSRTRTKAGRGRRRKF
What is the function of this protein?
Ubiquitin-binding protein (PubMed:24627472).  Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref. 38).  Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin.  May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo.  Does not bind Lys-48'-linked ubiquitin.  May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
What are the official names of this protein?
BRCA1-A complex subunit RAP80, Receptor-associated protein 80, Retinoid X receptor-interacting protein 110, Ubiquitin interaction motif-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the RAP80 family.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: NUOD_RALPJ
Sequence: MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSVPYMDRLDYVSMMVNEHAYVMAIERLLGLEVPLRAQYIRVMFDEITRIMNHLMWIGSHALDVGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVYRDLPDTMPQYKASKVRNEKALAALNQTRSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVGIGVVSPERALNKGFSGAMLRGSGIEWDVRKKQPYEVYDRIDFDIPVGVNGDCYDRYLVRVEEMRQSNRIIRQCIEWLRKNPGPVITDNHKVAPPSRVDMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFVHLAALDEMAKGHMIADAVTIIGTQDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: EXSE_TRICO
Sequence: MLYKKLRSQGNFRKNDSAYFKLENKRELKGDNLPVEEKVRQTIEKFKDDVSEIRRLADDSDFGCNGKETGGAMHIVCFFQKNYDWMKGQWQN
What are the official names of this protein?
11 kDa excretory-secretory protein, TCADES4.
Protein: RL35_STAA2
Sequence: MPKMKTHRGAAKRVKRTASGQLKRSRAFTSHLFANKSTKQKRQLRKARLVSKSDMKRVKQLLAYKK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: METJ_PROMH
Sequence: MAEWNGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLKHATNSELLCEAFLHAFTGQPLPNDEDLRKERNDEIPEEAKEIMRQRGVDPETWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRE2_YEAS7
Sequence: MSQYKTGLLLIHPAVTTTPELVENTKAQAASKKVKFVDQFLINKLNDGSITLENAKYETVHYLTPEAQTDIKFPKKLISVLADSLKPNGSLIGLSDIYKVDALINGFEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNNTKLQSGSKLPTFKKASSSTSNLPSFKKADHSRQPIVKETDSFKPPSFKMATEPKVYRVVDDLIEDSDDDDFSSDSSKAQYFDQVDTSDDSIEEEELIDEDGSGKSMITMITCGKSKTKKKKACKDCTCGMKEQEGKEINDIRSQQDKVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLDSISDDL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: HUTU_XANC5
Sequence: MTRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAEHPQELVVYGGIGRAARDWESFDAIVAALTRLDEDQTLLVQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFSELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYAGNLAGKWLFTGGLGGMGGAQPLAAVMAGASCLVVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTAKKPLSVGLLGNVADVLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSARKEVEAAARESMANHIRAMLTFHALGVPTVDYGNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIAFQGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRIERVLWNDPATGVMRHADAGYAIATDCAKEKGLDLPGILR
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_BURP6
Sequence: MSRVGKSPIALQGAEVKLADGAITVKGPLGTITQAVNPLVNVANNDGTLNLSPVDDSREANALSGTMRAIIANAVHGVTKGFERKLTLVGVGYRAQAQGDKLNLSLGFSHPVVHQMPEGIKAETPTQTEIVIKGIDKQKVGQVAAEVRGYRPPEPYKGKGVRYADEVVILKETKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: DI195_ORYSJ
Sequence: MEVEASYSYGFLPSGRHQPYAPPPPHPAEEGELWEYFPCPFCYIEVEVPFICNHLQEEHCFDTRNAVCPLCADNIGRDMGAHFRVQHSHLLKRRKPSRPSSSWPTPSNNSDPYFEGPPQYMMNNRTYQDPAPDPLLSQFICSMAQTDTNSDNTNTEIAVSAVSHDQRLSQRVTLTDDASKLELKERLQRIEFVKEIIMSTIL
What are the official names of this protein?
Protein DEHYDRATION-INDUCED 19 homolog 5, OsDi19-5.
What is the protein family that this protein belongs to?
Belongs to the Di19 family.
Protein: TRMB_PSEAB
Sequence: MSDTPQSPAQGSLAEHDEARPMRTVKSFVMRAGRMTEGQQRGLDLGWPKFGLELSDEVQDFDAIFGRQAPRTFEIGFGMGHSTLEMAAAAPDIDFIGVEVHKPGVGALLNGLLTQGLGNVRVYSCDALEVLRHCVADASLDRLLLFFPDPWHKKRHHKRRIVQPEFAELVRRKLKVGGVLHMATDWEPYAEHMLDVMSAAPGYRNQAEDGRFVARPQERPVTKFERRGERLGHGVWDLKFERID
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: Y664_CHLMU
Sequence: MRRSTEFGVKTAGGSMTTIFERIIEGAVECDKVFEDENFIVIKDKFPQAPVHLLIIPKKHIEKLQDMQSDDFSLLSEAGKIIQLMARDFGIENGYRVVINNGLEGGQSVFHLHIHLLGGGLLGSIA
What are the official names of this protein?
Uncharacterized HIT-like protein TC_0664.
Protein: KTHY_STRA5
Sequence: MKKGLMISFEGPDGAGKTTVLEAVLPLLREKLSQDILTTREPGGVTISEEIRHIILDVKHTQMDKKTELLLYMAARRQHLVEKVLPALEEGKIVLMDRFIDSSVAYQGSGRGLDKSHIKWLNDYATDSHKPDLTLYFDVPSEVGLERIQKSVQREVNRLDLEQLDMHQRVRQGYLELADSEPNRIVTIDASQQLDEVIAETFSIILDRINQ
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: IGS11_HUMAN
Sequence: MTSQRSPLAPLLLLSLHGVAASLEVSESPGSIQVARGQPAVLPCTFTTSAALINLNVIWMVTPLSNANQPEQVILYQGGQMFDGAPRFHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDIGGRNIGVTGLTVLVPPSAPHCQIQGSQDIGSDVILLCSSEEGIPRPTYLWEKLDNTLKLPPTATQDQVQGTVTIRNISALSSGLYQCVASNAIGTSTCLLDLQVISPQPRNIGLIAGAIGTGAVIIIFCIALILGAFFYWRSKNKEEEEEEIPNEIREDDLPPKCSSAKAFHTEISSSDNNTLTSSNAYNSRYWSNNPKVHRNTESVSHFSDLGQSFSFHSGNANIPSIYANGTHLVPGQHKTLVVTANRGSSPQVMSRSNGSVSRKPRPPHTHSYTISHATLERIGAVPVMVPAQSRAGSLV
What is the function of this protein?
Functions as a cell adhesion molecule through homophilic interaction.  Stimulates cell growth.
What are the official names of this protein?
Immunoglobulin superfamily member 11, IgSF11, Brain and testis-specific immunoglobulin superfamily protein, Bt-IGSF, V-set and immunoglobulin domain-containing protein 3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: MINC_ECO7I
Sequence: MSNTPIELKGSSFTLSVVHLHEAEPKVIHQALEDKIAQAPAFLKHAPVVLNVSALEDPVNWSAMHKAVSATGLRVIGVSGCKDAQLKAEIEKMGLPILTEGKEKAPRPAPAPQAPAQNTTPVTKTRLIDTPVRSGQRIYAPQCDLIVTSHVSAGAELIADGNIHVYGMMRGRALAGASGDRETQIFCTNLMAELVSIAGEYWLSDQIPAEFYGKAARLQLVENALTVQPLN
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: RS21_MAGMM
Sequence: MRVDVYDNNVDQAIRVLKKKMNREGMFREMKKRKFFEKPSERRRRKKAEAIRRLRKKLRRASLAGLG
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: ATG9B_HUMAN
Sequence: MVSRMGWGGRRRRLGRWGDLGPGSVPLLPMPLPPPPPPSCRGPGGGRISIFSLSPAPHTRSSPSSFSPPTAGPPCSVLQGTGASQSCHSALPIPATPPTQAQPAMTPASASPSWGSHSTPPLAPATPTPSQQCPQDSPGLRVGPLIPEQDYERLEDCDPEGSQDSPIHGEEQQPLLHVPEGLRGSWHHIQNLDSFFTKIYSYHQRNGFACILLEDVFQLGQFIFIVTFTTFLLRCVDYNVLFANQPSNHTRPGPFHSKVTLSDAILPSAQCAERIRSSPLLVLLLVLAAGFWLVQLLRSVCNLFSYWDIQVFYREALHIPPEELSSVPWAEVQSRLLALQRSGGLCVQPRPLTELDIHHRILRYTNYQVALANKGLLPARCPLPWGGSAAFLSRGLALNVDLLLFRGPFSLFRGGWELPHAYKRSDQRGALAARWGRTVLLLAALNLALSPLVLAWQVLHVFYSHVELLRREPGALGARGWSRLARLQLRHFNELPHELRARLARAYRPAAAFLRTAAPPAPLRTLLARQLVFFAGALFAALLVLTVYDEDVLAVEHVLTAMTALGVTATVARSFIPEEQCQGRAPQLLLQTALAHMHYLPEEPGPGGRDRAYRQMAQLLQYRAVSLLEELLSPLLTPLFLLFWFRPRALEIIDFFHHFTVDVAGVGDICSFALMDVKRHGHPQWLSAGQTEASLSQRAEDGKTELSLMRFSLAHPLWRPPGHSSKFLGHLWGRVQQDAAAWGATSARGPSTPGVLSNCTSPLPEAFLANLFVHPLLPPRDLSPTAPCPAAATASLLASISRIAQDPSSVSPGGTGGQKLAQLPELASAEMSLHVIYLHQLHQQQQQQEPWGEAAASILSRPCSSPSQPPSPDEEKPSWSSDGSSPASSPRQQWGTQKARNLFPGGFQVTTDTQKEPDRASCTD
What is the function of this protein?
Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion.  Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome.  Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity).  In addition to autophagy, also plays a role in necrotic cell death (By similarity).
What are the official names of this protein?
Autophagy-related protein 9B, APG9-like 2, Nitric oxide synthase 3-overlapping antisense gene protein, Protein sONE.
What is the protein family that this protein belongs to?
Belongs to the ATG9 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool (PubMed:18936157). The starvation-induced redistribution depends on ULK1 and ATG13 (PubMed:18936157).
Protein: CLGR_MYCTO
Sequence: MAALVREVVGDVLRGARMSQGRTLREVSDSARVSLGYLSEIERGRKEPSSELLSAICTALQLPLSVVLIDAGERMARQERLARATPAGRATGATIDASTKVVIAPVVSLAVA
What is the function of this protein?
Key stress-response regulator that plays an important role in multiple regulatory networks in response to different stress conditions (PubMed:20701538, PubMed:24705585).  Required to manage host-derived stress during infection (PubMed:20701538).  Plays a role during hypoxia and reaeration (PubMed:25422323).  Controls the expression of many genes involved in heat shock, virulence, lipid metabolism, transport or regulation, including clpP1, clpP2, clpC1, hsp, groES, otsA, pknD, prcA and prcB (PubMed:19376862, PubMed:20701538).  May function by protecting intracellular redox potential and by inducing the expression of trehalose, a constituent of cell walls that is important for defense against cell-surface and oxidative stress (PubMed:20701538).  Also performs different functions during stress response and is important for the pathogenicity of M. tuberculosis in vivo, regardless of the induction of the Clp proteolytic pathway (PubMed:24705585).  May directly activate SigE and/or SigH (PubMed:24705585).
What are the official names of this protein?
Transcriptional regulator ClgR.
Protein: GLB7A_CHITH
Sequence: MKFFAVLALCIVGAIASPLSADQAALVKSTWAQVRNSEVEILAAVFTAYPDIQARFPQFAGKDVASIKDTGAFATHAGRIVGFVSEIIALIGNESNAPAVQTLVGQLAASHKARGISQAQFNEFRAGLVSYVSSNVAWNAAAESAWTAGLDNIFGLLFAAL
What are the official names of this protein?
Globin CTT-VIIA.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: HEM3_BACC3
Sequence: MRKIIVGSRKSKLALTQTNWFIDQLKALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLFVKEIEHALLTKEIDMAVHSMKDMPAVLPEGLMIGCTPKRVDPRDAFISKSGASFKELAEGAILGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLKEEDYDAIILATAGLQRMGWDNEVITEHLDETLCVPAVGQGALAIECREDDKDLLQLLAHINDAVTEKTVAAERVFLHKLEGGCQVPIAGYATLTENDAIELTALVGSMDGSVLLKETVVGTDPEKVGLEAADRLIKQGAKELILAANKGQQ
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: MAK5_GIBZE
Sequence: MVPPSKKRKLPAATGPATKRSKNIPKPSSSKKKSGKESRSTVEAGALSWASVGEDFGGLEVIEGVDVVKDGNRVQFLVSGDKNKSNIIDPQQEVVDGDRPFEGFGDDAVEVGDIDSGEVGSDQAGAESKKPQGKNKGKNEPKEGQEKADQETNKKQKQKQNKNKLDGKNGAGNKQDEQLVKAAQGVQKSSTRGGNTFGALADGNDYKDQEDVDMAAWVSLNLSPQIISAIAKLKFMKPTKIQKRTIPEIVAGHDVIGKAQTGSGKTLAFGIPMVERWLEMQEQGVKRTGPMSLVLSPTRELAKQLGDHLKALCDGLPSAPYVCVVTGGLSILKQQRQLEKADIVIGTPGRLWEVLSGDRALQSKFAKIRFLVVDEADRLFKVGQFKEAEDIIGALDGKSPGDDAESEEESDEEDEDDEDAARQTLVFSATFDKDLQTKLAGKGKSSGNDDEKMAYLMKCLKFRGEPKFIDVNPVSQMAEGLREGLIECGAMEKDLYLYTVLILNPGRRTLVFTNSISAVRRLTPLLTNLNLTALPLHSQMAQKARHRSLERFTASRNSILIATDVAARGLDIKEVDQVLHYHVPRSADTYIHRSGRTARGESSGISVILCAPEEVLPTRRLASKVHAVRSAGVKREHFIQTLLIDRKAASRLKPRVDLAKKIADTILAKEKAHSDDTWLRNAADELGVEYDSDDLEEINAGGGKGGRGGGRKRKEQTAKQLTKAEMGALKAQLREELSRRVNLGVSERYITGGRVDVGALLREGQQGGMFLGNTDGLGFDL
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase MAK5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CUME_CONCL
Sequence: GRPSARYDAPYCSEEELQACDCSHNPVRDACQCAYDPAGSPACDCYCVEPWRR
What is the function of this protein?
Probable neurotoxin with unknown target.  Possibly targets ion channels.
What are the official names of this protein?
Conotoxin Cal22e.
What are the subcellular locations of this protein?
Secreted.
Protein: GSA_SULIK
Sequence: MDKGRCTILNSEELWAQARQLFAGGVNSPVRAAVKPFPFYVERGKGAYIYTVEGNKFIDYVLGYGPLILGHSPESVKRKIIEQLEKGWLFGTPSKLEIELAKKISSHIPSAQKIRFVNSGTEATMAAIRLARGYSKRSKILKFSGNYHGAHDYTLVEAGSAATEYNVTTSDGIPMEIMKTVEICEFNDLDCVDKKLRNEDIAAALLEPIMGNAGVILPEKGFLSGLRELTKSYNSLLIFDEVITGFRIDIGGAQSYYQIYPDITTLGKIIGGGFPIGAVAGKAEIIDNFTPAGRVFNAGTFNANPISMIAGIATIEELEKEYPYNIANKASKTLVEELERLLKIKHTINHIGSMFQVFFGIDKVRNYSDAKRANKEYYIKFHERLLKERVFIPPSQYETIFTSAAHEDDVVNDTIDKLAKVIGELS
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI45_BOVIN
Sequence: MAEKRRPLLGFVGKLPSGTTAGNSGKTHCPLCMGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGESDTSSEGSVFQELKPRALQPQIGILCPVCDAQVDLPMGGVKALTIDHLAMNDVMLESLRGEGQGLVCDLCSDREVEKRCQTCKANLCRFCCQAHRRQKKTTYHTMVDLKDLKGYSQIGKPILCPAHPAEELRLFCELCDRPVCRDCVVGEHREHPCDFTSNVIHKHGDSVRELLRGTQPHVEALEEALAQIKGTNSAVQERVKAVAADIRTFSEGYIKAIEEHRDKLLKQLEDIRVQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVERLTKLNKVEYSAHPGVNEKISFSPKQKAGLCRGYEVYGAINTKEVDPAKCVLQGEDLHRAREKQPASFIVLCKDATGESMGRGGDNVQVTVIPNDKKDSPVKTMVHDNKDGTYYVSYTPKEPGTYTVLVCVKEQHVQGSPFTVTVRKRHRSHPGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFAEKSECTWAGGQSAPRSLLRTVAL
What is the function of this protein?
May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
What are the official names of this protein?
Tripartite motif-containing protein 45.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: UREG_PSE14
Sequence: MNSQPLRVGIGGPVGSGKTALTLALCLALRDRYNLAVVTNDIYTREDADFLVRNEALAPERIIGVETGGCPHTAIREDASINLEAVDQLNRRFEGLDLIIVESGGDNLSATFSPELSDLTIYVIDVSAGDKLPRKGGPGICKSDLLVINKIDLAPLVGASLEMMDSDTRRMRGEKPFVFSNQKTGQGLEQIIAFIERQGLLTAAA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEC_STRP1
Sequence: MKKINIIKIVFIITVILISTISPIIKSDSKKDISNVKSDLLYAYTITPYDYKNCRVNFSTTHTLNIDTQKYRGKDYYISSEMSYEASQKFKRDDHVDVFGLFYILNSHTGEYIYGGITPAQNNKVNHKLLGNLFISGESQQNLNNKIILEKDIVTFQEIDFKIRKYLMDNYKIYDATSPYVSGRIEIGTKDGKHEQIDLFDSPNEGTRSDIFAKYKDNRIINMKNFSHFDIYLEK
What is the function of this protein?
Superantigen that acts as a causative agent of the symptoms associated with scarlet fever.  Has been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.  Superantigens cross-link major histocompatibility complex (MHC) class II and T-cell receptor (TCR) molecules, resulting in an overstimulation of T-cells associated with a massive release of pyrogenic and inflammatory cytokines.
What are the official names of this protein?
Exotoxin type C, SPE C.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
Protein: PURQ_GLUOX
Sequence: MKAAIVVFPGTNRERDMVHALKLVTGQAPRLIWHGETSLGDLDLVVLPGGFSFGDYLRSGAVAAHSPIMRDVKAFAGKGGHVLGVCNGFQILTESHLLPGALLRNAGLRFLSQDCHLKVENASSPYTQGWTRGDVFRAPLAHGDGNYTASPETLKRLEGEGRVAFRYCGADGAVSDDDRTTNPNGSTRSIAGILSENGRVCGLMPHPENLTDPEIGATDGVPLFKGLVEALVG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATN2_HUMAN
Sequence: MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
What is the function of this protein?
Involved in matrix assembly.
What are the official names of this protein?
Matrilin-2.
What are the subcellular locations of this protein?
Secreted.