PharMolix/UniProtQA huggingface dataset:
Protein: TRAD1_HUMAN
Sequence: MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE
What is the function of this protein?
Negative feedback regulator that controls excessive innate immune responses.  Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways.  May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation.  May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).
What are the official names of this protein?
TRAF-type zinc finger domain-containing protein 1, Protein FLN29.
Protein: GT315_ABVP
Sequence: MTMITFLTTTQNGSYDRLATRQAVFLKQNLNVDSQIIRMAQTQLVPVKGSHVIIYTTFNIYPVLINKYRQQLEGKKCVALLDSALMTIPYRNPVFKDPICTVYTTSRFNQENFATLGVSIPYIPHFIPDPNPEGKLKSLSERQYDFITVGINEMDFDRKGHFWNFLVQRWGFKAISVCKFYCFGDHKQDLPDEELWSLYANTKWYLGTSHAETPHLPLLEAYAFGTPAVYISAHEFRYIGFGIPISPAYINVKGTKNFYFAEINTESFIQAVGKAMRMSEGDYNSLSKQARRFFENNYSLNNRVDEFRALFDDSM
What are the official names of this protein?
Putative glycosyltransferase ORF315.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: LPOA_SHIF8
Sequence: MVPSTFSRLKAARCLPVVLAALIFAGCGTHTPDQSTAYMQGTAQADSAFYLQQMQQSSDDTRINWQLLAIRALVKEGKTGQAVELFNQLPQELNDSQRREKTLLAAEIKLAQKDFAGAQNLLAKITPADLEQNQQARYWQAKIDASQGRPSIDLLRALIAQEPLLGAKEKQQNIDATWQALSSMTQEQANTLVINADENILQGWLDLQRVWFDNRNDPDMMKAGIADWQKRYPNNPGAKMLPTQLVNVKAFKPASTNKIALLLPLNGQAAVFGRTIQQGFEAAKNIGTQPVAAQVAAAPAADVAEQPQPQTADGVASPAQASVSDLTGDQPAAQPVPVSAPATSTAAVSAPANPSAELKIYDTSSQPLSQILSQVQQDGASIVVGPLLKNNVEELLKSNTPLNVLALNQPENIENRVNICYFALSPEDEARDAARHIRDQGKQAPLVLIPRSALGDRVANAFAQEWQKLGGGTVLQQKFGSTSELRAGVNGGSGIALTGSPITPRATTDSGMTTNNPTLQTTPTDDQFTNNGGRVDAVYIVATPGEIAFIKPMIAMRNGSQSGATLYASSRSAQGTAGPDFRLEMEGLQYSEIPMLAGGNLPLMQQALSAVNNDYSLARMYAMGVDAWSLANHFSQMRQVQGFEINGNTGSLTANPDCVINRKLSWLQYQQGQVVPAS
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
What are the official names of this protein?
Penicillin-binding protein activator LpoA, PBP activator LpoA.
What is the protein family that this protein belongs to?
Belongs to the LpoA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: PCKG_ACIBY
Sequence: MTTVNAPEFVRHPKLIAWVEEIANLTKPAKIEWCDGSEEEYQRLIDLMIANGTMQKLNQEKHPGSYLANSDPSDVARVEDRTYICSQNKEDAGATNNWEDPAVMREKLNGLFEGSMKGRTMYVVPFSMGPLGSHIAHIGIELTDSPYVAVSMRKMARMGKAVYDVLGTDGEFVPCVHTVGAPLAEGQKDVAWPCNPEKYIVHYPETREIWSFGSGYGGNALLGKKCLALRIASVMGREQGWLAEHMLILGVTNPQGEKHYIAAAFPSACGKTNFAMLIPPAGYEGWKIETVGDDIAWIKPGEDGRLYAINPEAGFFGVAPGTNTKTNPNCMATLHKDVIYTNVAVTDDGQVWWEGLSKEVPANLTNWKGQPHVNGEKAAHPNARFTVAAGQCPSIDADWENPAGVPISAFIFGGRRADTVPLVSEAFDWVDGVYKAATMGSETTAAAVGQQGIVRRDPFAMLPFAGYNMADYFDHWLNLGAKVSEKAEASGNKLPKIFNVNWFRRDAEGNFVWPGFGQNMRVLEWIIDRCEGRANAVETPIGFVPTYEDLNWEGTEFTKEQFDLITNQDRDQWVTEIESHTELFNKLGERLPKALKERQAALLEAVKTGF
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCPS_SCHPO
Sequence: MEESSAAKIQLLKEFKFEKILKDDTKSKIITLYGKIRNEVALLLLEKTAFDLNTIKLDQLATFLQDTKLVENNDVFHWFLSTNFQDCSTLPSVKSTLIWPASETHVRKYSSQKKRMVCETPEMYLKVTKPFIETQRGPQIQWVENILTHKAEAERIVVEDPDPLNGFIVIPDLKWDRQTMSALNLMAIVHATDIASIRDLKYKHIPLLENIRNKVLTEVPKQFSVDKNQLKMFVHYLPSYYHLHVHILHVDHETGDGSAVGRAILLDDVIDRLRNSPDGLENVNITFNIGEQHFLFQPLTNMNA
What is the function of this protein?
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.  Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP).  Has no activity towards mRNA molecules longer than 25 nucleotides.  May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCS1 to m7GMP.  Inhibits mRNA translation.  Binds to the m7GpppG cap analog.
What are the official names of this protein?
m7GpppX diphosphatase, Hint-related 7meGMP-directed hydrolase 1, Nuclear histidine triad (HIT) motif protein 1, Scavenger mRNA-decapping enzyme DcpS.
What is the protein family that this protein belongs to?
Belongs to the HIT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly nuclear.
Protein: UTR4_ARATH
Sequence: MKTNSEEQMIKLFGIPLSDKPRWQQFLICSSGFFFGYLVNGICEEYVYNRLKFSYGWYFTFAQGLVYIALIYMYGFRTKQMVNPWKTYVKLSGVLMGSHGLTKGSLAYLNYPAQIMFKSTKVLPVMVMGAFIPGLRRKYPVHEYISAMLLVIGLILFTLADAHTSPNFSIIGVMMISGALIMDAFLGNLQEAIFTMNPETTQMEMLFCSTVVGLPFLLAPMILTGELFTAWNSCAQHPYVYGVLVFEAMATFIGQVSVLSLIALFGAATTAMITTARKAVTLLLSYLIFTKPLTEQHGTGLLLIFMGIILKMVPDPNPNPKSSGSGQTPGKLERVKFEKEDDEESRPLV
What is the function of this protein?
Sugar transporter involved in the transport of nucleotide-sugars from cytoplasm into the Golgi and/or the endoplasmic reticulum.
What are the official names of this protein?
UDP-galactose/UDP-glucose transporter 4, AtUTr4.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. UDP-galactose:UMP antiporter (TC 2.A.7.11) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PLSX_RHOP5
Sequence: MSNKVRIALDAMGGDFGASVVVPGAAISLTRHPDSEFLLFGDSALIKKELEAHPALKAVSQVIHTDVAVSMHDKPSQALRRGRKVSSMWLALEAVKNGKADVAVSAGNTGALMAMARFCLRMLPGIDRPAIAAIWPTVRGDSIVLDLGASIGGDEHHLKALAVMGAATASVLFDLERPTVGLLNIGVEEIKGGEEIRAAADLIRAMAQPPFDFIGFVEADGIGKGAADVIVTEGFSGNIALKAAEGTARQIGEYLRAAMSSTLMSKIGYLFARGAFRALREKMDPNKSNGGVFLGLNGVVVKSHGGTNADGFAYAVDVGYDMVRNDLLTKINQSLHRNGAEAHGVAPAA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RS17E_NATPD
Sequence: MAIKPAYVKKTGTLLMDRYPKAFGDDFEHNKELVDELTNIESKSVRNRIAGYVTRKQRSPQQPA
What are the official names of this protein?
30S ribosomal protein S17e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: RKM5_LACTC
Sequence: MTAKLKLLDEDGIYEHLFERYSLLQKHANELKQDLGIVSRSSGDLEVSFEPQPGSHVKEHFNFEIAQSLSSLNSSRDNNNSTTGYVVWSTTPFFLQWLLYSPSGAIFGKGGTIEVEGDASHSAYELPAIFGSRTVDTDESSDVPAAPQHIIVELGAGIAGMLCVALANYVDKYVCTDQKGLLNGLKRNIKHNIDELRLRNMESSTLDFEISRRTALKTELDVLDLDWESFGLKSSNFHTLITPAGPSTVCILSMDVVYNEFLIAPYLRTLKKLLQTYEKSGNTSFAILGIQLRDQDVVEMFLSTAVVQFELKVCAIVDSEIDKTRFGLYYITTQ
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates 60S ribosomal protein L1.
What are the official names of this protein?
Ribosomal lysine N-methyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RKM5 family.
Protein: Y891_FRATW
Sequence: MYQNHKSEILLATPLIKDDIVFTKSVVYLCQNDRHGAMGLIINKPLADTLKDVFEELHIPHTNTFKEILEYPLYMGGPISPHKIMILHTTNGRNYTSTIKLDEGLAITASIDILEDIANNILPEYFLPVVGYSCWTANQLTDEIKSNDWIVTNKLNKKILFNHENKVKWQNHLEHAGYTLQSLDTLFNRNTGNC
What are the official names of this protein?
UPF0301 protein FTW_0891.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: ESTP_PSEPK
Sequence: MRKAPLLRFTLASLALACSQALAGPSPYSTLIVFGDSLADAGQFPDLVGGTPGARFTNRDADGNFAPVSPMILGGRLGVAPGDLNPSTSVGIQPDGNNWAVGGYTTQQILDSITTTSETVIPPGNPNAGLVLRERPGYLANGLRADPNALYYLTGGGNDFLQGLVNSPADAVAAGARLAASAQALQQGGARYIMVWLLPDLGQTPNFSGTPQQNPLSLLSAAFNQSLISQLGQIDAQIIPLNIPLLLSEALASPSQFGLASDQNLVGTCYSGDSCVENPVYGINGTTPDPTKLLFNDSVHPTIAGQQLIADYAYSILAAPWELTLLPEMAHASLRAHQDELRNQWQTPWQAVGQWQAFVASGAQDLDFDGQHSAASGDGRGYNLTVGGSYRLNDAWRLGLAGGANRQKLEAGEQDSDYKLNSYMASAFAQYRQDRWWADAALTAGHLDYSDLKRTFALGVNDRSEKGDTDGEAWAMSGRLGYNLAADTSNWQLAPFISADYARVKVDGYDEKSGRSTALGFDDQERTSRRLGVGLLGSVQVLPSTRLFAEVAQEHEFEDDEQDVTMHLTSLPANDFTLTGYTPHSDLTRASLGVSHELVAGVHLRGNYNWRKSDELTQQGISVGVSVDF
What is the function of this protein?
Esterase that catalyzes the hydrolysis of p-nitrophenyl esters of acyl chain lengths C4-C10 and Tween detergents.  Has also a pronounced thioesterase activity towards palmitoyl-coenzyme A.
What are the official names of this protein?
Esterase EstP, Autotransporter esterase EstP, Palmitoyl-CoA hydrolase.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: UGTP_BACCR
Sequence: MIKNPKVLILTAHYGNGHVQVAKTLEQTFRQKGIEDVIVCDLFGESHPFITDITKYLYLKSYTIGKELYRLFYYGVEKIYDKKIASWYANFGRKRLKTLLQVEKPDIVINTFPIIAVPELKKQTGISIPVYNVLTDFCVHKIWIHREVDRYFVATDHVKELMVDIGVPAEQIVETGIPIRSSFELKVNPEIIYTKYQLCKNKKILLIVAGAHGVLGNVKELCQSFMSVPNLQVVVVCGKNEALKQDLLSLQKQNSDALKVFGYVENIDELFRVTSCMITKPGGITLSEAAALQVPVILYKPVPGQENENAMYFERKGAAVVIRDDSEVFAKTEALLQDDVKLLQMKEAMKSIYLPEPAGHIVDAILAENHAEPRHIPIKSPALAQSFT
What is the function of this protein?
Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids.  Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol).  Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).
What are the official names of this protein?
Processive diacylglycerol beta-glucosyltransferase, Beta-diglucosyldiacylglycerol synthase, Beta-DGS, DGlcDAG synthase, Glc2-DAG synthase, Beta-gentiobiosyldiacylglycerol synthase, Beta-monoglucosyldiacylglycerol synthase, Beta-MGS, MGlcDAG synthase, Beta-triglucosyldiacylglycerol synthase, TGlcDAG synthase, Diglucosyl diacylglycerol synthase (1,6-linking), Glucosyl-beta-1,6-glucosyldiacylglycerol synthase, UDP glucosyltransferase, UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. UgtP subfamily.
What are the subcellular locations of this protein?
Cell membrane.
Protein: GABD_ECOLI
Sequence: MKLNDSNLFRQQALINGEWLDANNGEAIDVTNPANGDKLGSVPKMGADETRAAIDAANRALPAWRALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFAEEGKRIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKPASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTEIGRQLMEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGVYDRFAEKLQQAVSKLHIGDGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKAHERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYARDLSRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCIGL
What is the function of this protein?
Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate (PubMed:20174634).  Thereby functions in a GABA degradation pathway that allows some E. coli strains to utilize GABA as a nitrogen source for growth (PubMed:7011797).  Also catalyzes the conversion of glutarate semialdehyde to glutarate, as part of a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate (PubMed:30498244).
What are the official names of this protein?
Succinate-semialdehyde dehydrogenase [NADP(+)] GabD, SSDH, Glutarate-semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: MTFA_SALCH
Sequence: MIKWPWKAQEITQNEDWPWDNALAIPLLVNLTAQEQARLIALAERFLQQKRLVALQGFELDSLKSARIALIFCLPILELGIEWLDGFHEVLIYPAPFVVDDEWEDDIGLVHSQRVVQSGQSWQQGPIILNWLDIQDSFDASGFNLIIHEVAHKLDMRNGDRASGIPFIPLRDVAGWEHDLHAAMNNIQDEIDLVGESAASIDAYAATDPAECFAVLSEYFFSAPELFAPRFPALWQRFCQFYRQDPSQRLRVSAAEGDYGEESEH
What is the function of this protein?
Involved in the regulation of ptsG expression by binding and inactivating Mlc.
What are the official names of this protein?
Protein MtfA, Mlc titration factor A.
What is the protein family that this protein belongs to?
Belongs to the MtfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_RICRO
Sequence: MAKVSSIKKNESRKKKSQSLHNKRLALKSKIYDKNISLEERFSLVMSLAQLPRNSSSTRIRNRCELTGRPRGVTRKFGISRNKLRELIGRGLVPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RIMM_LEPBL
Sequence: MTEGWISLGQLGKPFGIKGWLRFNVRDSILTKVKLPVRLKLGKSDPNFPETEIILLEIRPHNGKFVVRFEGIATPEEAEKWVGGILFLPQNLLPKIETKDEFYVRDLIGLQAIDEFGKSLNWKLTDIQDNPAHPILVFSKSEEEEILIPFLHVFVGELNLEKKTIVLIQPELWNEV
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBJ_SOLLC
Sequence: MADTTGRIPLWIIGTVAGILVIGLIGIFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RECX_AZOVI
Sequence: MPGLDSPAAVRRAAMDLLAR
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_BRUME
Sequence: MFNTHKVEIEWGGRPLTLETGKIARQADGAVLATYGETAVLATVVSAKEPKPGQDFFPLTVNYQEKTYAAGKIPGGYFKREGRPSENETLVSRLIDRPIRPLFVDGYKNDTQVVITVLQHDLENNPDILSMVAASAALTISGVPFMGPISGARVGYIDGEYVLNPNIDEMPESKLDLVVAGTSEAVLMVESEAQELPEDVMLGAVMFGHKSFQPVIDAIIKLAEVAAKEPRDFQPEDLSELEAKVLAVVENDLREAYKITEKQARYAAVDAAKAKAEEHFFPEGVEETEMSAEQFATIFKHLQAKIVRWNILDTGNRIDGRDLSTVRPIVSEVGILPRTHGSALFTRGETQAIVVATLGTGEDEQMIDALTGTYKESFMLHYNFPPYSVGETGRMGSPGRREIGHGKLAWRAIHPMLPAAEQFPYTIRAVSEITESNGSSSMATVCGTSLALMDAGVPIVRPVAGIAMGLIKEGERFAVLSDILGDEDHLGDMDFKVAGTEFGITSLQMDIKIDGITEEIMKVALEQAKGGRVHILGEMAKAISSSRAELGEFAPRIEVMNIPTDKIRDVIGSGGKVIREIVEKTGAKINIEDDGTVKIASSNGKEIEAAKKWIHSIVAEPEVGEIYEGTVVKTADFGAFVNFFGPRDGLVHISQLAADRVAKTTDVVKEGQKVWVKLMGFDERGKVRLSMKVVDQETGKEIVAEKKKEEVDAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WTF18_SCHPO
Sequence: MKNNYTSLKSPLDEEDELKTDHEIDLEKGLLPEYNSEEEGTLPLYSDISKLANPVPEDSSTGPTEIANPNVERRQEFKDSHPNIYFLLRLLISVLAVSVVFFTAWVCVNPLEKSIFGKVAFSVTIGITCPILFIATFCFFETWTQAVAQCIKVTVIFLAQCVKVTVIFLAQCVKVTAVFLAKCVKVIAVGLYNSKKDLVVTIWLAWVVICFILFGCVKDGRLNLNKALICSTCSISAALFFILLLVCIPIWTLKHMLFGLFQVLGVQSCVVIVTKGLMYLFDKHIDATGYEIEASSLFVIGNFLFFYEMECPGALKRMPKFIRNGIASFLEGIGNAFGGIGNAIGRIGNAFRGANDNNNNIPLEETEAESEV
What is the function of this protein?
Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons (PubMed:30475921).  Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole (By similarity).  Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote (PubMed:30475921).
What are the official names of this protein?
Meiotic drive suppressor wtf18.
What is the protein family that this protein belongs to?
Belongs to the WTF family.
What are the subcellular locations of this protein?
Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: BST1_SCHPO
Sequence: MKDDKGRSDTVNGYYISNSKLSSGFYKRNNANTASNDEKPNLEQNDIPSVTSSGSSTPSSISIEKEIKISKGNVIVKAIRSWSLYVAIIAILLLLVILHSFQGRPQDNGCGKSYVWPSYVRFVDFDERYTRFANKYSLYLYREKSVEESDEPSGIPILFIPGNAGSYKQVRAFAAQAAHVYANAYAEDADGTLNAGKLVPDFFVVDFNEDFSAFHGQTLLDQAEYVNDAIPYILSLYRQNRKISSEYDNEAFPPPTSVILLGHSMGGIVAQATFTMKNYVDGSVNTLITLATPHAMAPLPFDRHLVEFYESIKNFWSQSFLLSPEENSLDDVLLVSIAGGGLDTHVVPEYSSISTFVPPSNGLMVFTSGIPSVWAEIDHQAMAWCENFRRVLIRGIFAIMDARTSKCTVSLNLRKELLSRAYIQGSSFQNDITQISKPIAQYKALDLDLTYVYSEMPGQLLFLNQLGVSYIRHHIFPIPKPTSSIDRFELLTDQPIDLSSSNIKVLACRLDPKIDNTISALLENGNNKVINANCHLLRELVTLLPASTAYTSSPYGGDSFYNYVLPKEKMDDYHFILVSDDSKAPASGFVVGGFSNVSLDPKTIKGSQIELFKSGRKFQFDTKGSISKRFRFPGIQSSIMAYTISVTYELYPGAVPQKEFTPMLKQSIESPFETKYHVNMSNTELSVHGISPFMEFFGKESEKSLTLEFFLNPAIYKSVYVSIQPSYYRSAGRLLMRYRTLLASFPVVVISLAAYNQFRYFHYGSAYLSMSAALEVMIRKGLIKLLFLVSILSIAFSYLISRVELIVADGADPVASWKIFAMMVPKSFWKQNHLLFGLQTAQFWFLAPLLTLMFVGLVITASVIILCVMHLLAFIYGIYLRYKGLTFTGVCQAVKFSFQCLRTRNTRKLDHGEFKKLSSFLSQRNMYYANPSLCYVYGKKHMQARIIGIMLLLLMAMTVVPFQLVYGVALCTQTVTTAKALHLARFCTKSSHYRKKLWDFYNFSCTITILMLLLAPLDFPVLIVWARNLSMHWSIPFPTHHNFFSIIPFILLTEILRTGKMLPRLNDVEYYINNVFLFLLSFYSLIYGAEKPYLIHNVVGLYFFWLLFLYAKNGFFVQNISKWPIIPRMKYFIKHKFLRSIS
What is the function of this protein?
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
What are the official names of this protein?
GPI inositol-deacylase.
What is the protein family that this protein belongs to?
Belongs to the GPI inositol-deacylase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SEM3A_MOUSE
Sequence: MGWFTGIACLFWGVLLTARANYANGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLEAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSVPKETWHDLEEILLEEMTVFREPTTISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTHCSDLQHHDNHHGPSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRMGDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDDDGDGSKIKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHSQGSSNKWKHMQESKKGRNRRTHEFERAPRSV
What is the function of this protein?
Plays a role in growth cones guidance.  May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally.  Involved in the development of the olfactory system and in neuronal control of puberty (By similarity).
What are the official names of this protein?
Semaphorin-3A, Semaphorin III, Sema III, Semaphorin-D, Sema D.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ORML3_HUMAN
Sequence: MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMGMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQIHFVLNTVSLMSVLIPKLPQLHGVRIFGINKY
What is the function of this protein?
Negative regulator of sphingolipid synthesis.  May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
What are the official names of this protein?
ORM1-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the ORM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PSBF_CABCA
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PAND_ARTS2
Sequence: MNRTMFKSKIHRATVTHADLHYVGSVTVDLDLLEAADILPGELVAIVDVTNGARLETYTIAGERGSGVIGINGAAAHLMHENDIVILITYAEMTTEEAKAYTPKVVHVDKDNKIVQIGNDPAEGHTRGLMRPPFALNNSALN
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXAA2_ARAVE
Sequence: MALALLGLTIKPEHVPEGTGKAVADVEALACDPAQCMRSCPFNPFLNQYGGICKNGQCVCVKPS
What is the function of this protein?
Putative insecticidal toxin.
What are the official names of this protein?
U2-aranetoxin-Av1a, U2-AATX-Av1a, Toxin 2, AvTox-2.