PharMolix/UniProtQA huggingface dataset:
Protein: FUCI_ECOLI
Sequence: MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALLTEKLRHACGAAVECVISDTCIAGMAEAAACEEKFSSQNVGLTITVTPCWCYGSETIDMDPTRPKAIWGFNGTERPGAVYLAAALAAHSQKGIPAFSIYGHDVQDADDTSIPADVEEKLLRFARAGLAVASMKGKSYLSLGGVSMGIAGSIVDHNFFESWLGMKVQAVDMTELRRRIDQKIYDEAELEMALAWADKNFRYGEDENNKQYQRNAEQSRAVLRESLLMAMCIRDMMQGNSKLADIGRVEESLGYNAIAAGFQGQRHWTDQYPNGDTAEAILNSSFDWNGVREPFVVATENDSLNGVAMLMGHQLTGTAQVFADVRTYWSPEAIERVTGHKLDGLAEHGIIHLINSGSAALDGSCKQRDSEGNPTMKPHWEISQQEADACLAATEWCPAIHEYFRGGGYSSRFLTEGGVPFTMTRVNIIKGLGPVLQIAEGWSVELPKDVHDILNKRTNSTWPTTWFAPRLTGKGPFTDVYSVMANWGANHGVLTIGHVGADFITLASMLRIPVCMHNVEETKVYRPSAWAAHGMDIEGQDYRACQNYGPLYKR
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose (PubMed:13319278, PubMed:4928018, PubMed:4632320, PubMed:8564401, PubMed:9367760).  Also converts D-arabinose into D-ribulose (PubMed:13319278, PubMed:4928018, PubMed:4632320).  In addition, catalyzes the isomerization of L-xylulose to L-xylose (PubMed:22133443).
What are the official names of this protein?
L-fucose isomerase, FucIase, FucIso, 6-deoxy-L-galactose isomerase, D-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR19_PSINU
Sequence: MTRSLKKVPFVAHHLWKKIESLNIKKEKRVIITWSRASTIVPGMIGHTIAVYNGREHLPIYVTDRMVGHKLGEFVLTRTFRGHARKDKKSRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FIMB_YEAST
Sequence: MNIVKLQRKFPILTQEDLFSTIEKFRAIDLDDKGWVEKQQALEAVSKDGDATYDEARETLKHVGVDASGRVELDDYVGLVAKLRESKTGAAPQTTFNVAPNSTPIVSTAATGLQHKGKGTQAKIIVAGSQTGTTHTINEEERREFTKHINSVLAGDQDIGDLLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKKGKELNNFQASENANIVINSAKAIGCVVVNVHSEDIIEGREHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEDDETLEQFLRLPPEQILLRWFNYHLKQANWNRRVTNFSKDVSDGENYTILLNQLDPALCSKAPLQTTDLMERAEQVLQNAEKLDCRKYLTPSSLVAGNPKLNLAFVAHLFNTHPGLEPIQEEEKPEIEEFDAEGEREARVFTLWLNSLDVDPPVISLFDDLKDGLILLQAYEKVMPGAVDFKHVNKRPASGAEISRFKALENTNYAVDLGRAKGFSLVGIEGSDIVDGNKLLTLGLVWQLMRRNISITMKTLSSSGRDMSDSQILKWAQDQVTKGGKNSTIRSFKDQALSNAHFLLDVLNGIAPGYVDYDLVTPGNTEEERYANARLAISIARKLGALIWLVPEDINEVRARLIITFIASLMTLNK
What is the function of this protein?
Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity.
What are the official names of this protein?
Fimbrin, ABP67.
Protein: C5AR1_CANLF
Sequence: MASMNFSPPEYPDYGTATLDPNIFVDESLNTPKLSVPDMIALVIFVMVFLVGVPGNFLVVWVTGFEVRRTINAIWFLNLAVADLLSCLALPILFSSIVQQGYWPFGNAACRILPSLILLNMYASILLLTTISADRFVLVFNPIWCQNYRGPQLAWAACSVAWAVALLLTVPSFIFRGVHTEYFPFWMTCGVDYSGVGVLVERGVAILRLLMGFLGPLVILSICYTFLLIRTWSRKATRSTKTLKVVVAVVVSFFVLWLPYQVTGMMMALFYKHSESFRRVSRLDSLCVAVAYINCCINPIIYVLAAQGFHSRFLKSLPARLRQVLAEESVGRDSKSITLSTVDTPAQKSQGV
What is the function of this protein?
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1472004).  The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events.  Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).
What are the official names of this protein?
C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
Protein: ISCS_HELPY
Sequence: MLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFLESLGVEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANADFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSGTLNVPYIVGMGEAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLVSVRGIEGEAMLWDLNRSNIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAAVRLRNISSSY
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_THISH
Sequence: MAAKKYSAGVKEYRQTYWTPEYVPLDTDLLACFKITPQPGVDREEAAAAVAAESSTGTWTTVWTDLLTDMDYYKGRAYRIEDVPGDDECFYAFIAYPIDLFEEGSVVNVFTSLVGNVFGFKAVRALRLEDVRFPIAYVKTCGGPPHGIQVERDMMNKYGRPMLGCTIKPKLGLSGKNYGRAVYECLRGGLDFTKDDENINSQPFMRWRQRFDFVMEAIHKAEAETGERKGHYLNVTAPTPEEMYKRAEYAKEIGAPIIMHDYITGGFTANTGLANWCRDNGVLLHIHRAMHAVLDRHPKHGIHFRVLAKILRLSGGDHLHTGTVVGKLEGDRAATLGWIDLLREQFVPEDRSRGIMFDQDWGSMPGVFAVASGGIHVWHMPALVTIFGDDSVLQFGGGTLGHPWGNAAGAHANRVALEACVQARNEGRDVEREGKEILTAAAAHSPELKIAMETWKEIKFEFDTVDKLDVAHK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: CHM2B_PONAB
Sequence: MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.  ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.  The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses).  ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 2b, Chromatin-modifying protein 2b, CHMP2b.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein.
Protein: C2_TPCTV
Sequence: MVLCDKGAHELGNREIRKGFCERCLYPEYFDDEEAATTTPTIKKRPPKLTWAPKKKRRKAIHLSCGCSYYGGIDCEDGFTHRGITHVHTVPDWLLLRRHQEPNLLPPPEHNNNGDGEQNNNITNQSQPQPAESVGSPDLLAELGGTFSITSSEWRSIIR
What is the function of this protein?
Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  Suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway.  Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense.  Determines pathogenicity (By similarity).
What are the official names of this protein?
Protein C2, Protein L2.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae transcriptional activator protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: RL6_ECOL5
Sequence: MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: AT221_ASPCL
Sequence: MIFTSTPPAPPPADAQQRQPRYPGEDTTPTSRREIWGWYTYGIAAEVFAVCGVGSFLPLTLEQLARERGTLLSSHLPCVGPGSPSAAPGNGTTPAMLRRDGLGSDQCVVGLFGLQINTASFAMYTFSLAVLVQALTLISFSALADYEKNRKTLLLTFGLIGSVSSMLFVFISPRLYILGAILVVIGVTCLGSSFVVLNSFLPVLVANDPSIQTARKTEGEELPHLDSSGEYTRSGSFNRGDNRGFDDYVAPEHGLKPKTTDSTSPEMQLSTKISSKGVGLGYCAAVLVQVLSILLLFTLSKTSLPKISGTLPLRFVLLLVGIWWFSFTVVTRRWLRNRPGPPLDTSKGGARWRIWLRLVGFAWKSLWKTVKVAAKLREVVIFLIAWFLLSDAMATVSGTAILFARTELKMSTTAVGLLSITATLSGMTGAFLWPVVSRRLKLKSNHTIMLCIALFEIIPLYGMLAYIPLVKKWGVIGLQQPWEIFPLGIVHGLVSGGLSSYCRSFFGVLIPPGSEAAFYALYAATDKGSSFIGPAVVGVLIDATGQVRSGFFFIAVLIVLPIPLIWMVNAEKGRQEGLAMAEMLEKSHGENSSEFGHPSEEAEGLLARNP
What is the function of this protein?
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation.  The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).
What are the official names of this protein?
Autophagy-related protein 22-1.
What is the protein family that this protein belongs to?
Belongs to the ATG22 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Vacuole and punctate structures.
Protein: ACYP_SYNC1
Sequence: MKPIRVKVKVNGRVQGVGFRHFTYKTAISLELTGWVRNLEDGCVEAVAEGPRQQVEEWLAALKKGPPASKVAGLTIQREIVEGVFERFEVRF
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: MODU_DROME
Sequence: MAQKKAVTVKGKKATNGEEKPLAKRVTKSTKVQEEETVVPQSPSKKSRKQPVKEVPQFSEEDESDVEEQNDEQPGDDSDFETEEAAGLIDDEAEEDEEYNSDDEEDDDDDELEPGEVSKSEGADEVDESDDDEEAPVEKPVSKKSEKANSEKSEENRGIPKVKVGKIPLGTPKNQIVFVTNLPNEYLHKDLVALFAKFGRLSALQRFTNLNGNKSVLIAFDTSTGAEAVLQAKPKALTLGDNVLSVSQPRNKEENNERTVVVGLIGPNITKDDLKTFFEKVAPVEAVTISSNRLMPRAFVRLASVDDIPKALKLHSTELFSRFITVRRISQESISRTSELTLVVENVGKHESYSSDALEKIFKKFGDVEEIDVVCSKAVLAFVTFKQSDAATKALAQLDGKTVNKFEWKLHRFERSTSGRAILVTNLTSDATEADLRKVFNDSGEIESIIMLGQKAVVKFKDDEGFCKSFLANESIVNNAPIFIEPNSLLKHRLLKKRLAIGQTRAPRKFQKDTKPNFGKKPFNKRPAQENGGKSFVKRARF
What is the function of this protein?
Its capacity to bind DNA and protein(s), and its differential expression during development suggest a role in the regulation of gene expression during Drosophila development.  It could, in interaction with other factors, be required for the translation of instructions provided by pattern forming genes and controls, via chromatin changes, the activity of genes critical for the process of morphogenesis of several embryonic territories.
What are the official names of this protein?
DNA-binding protein modulo.
What are the subcellular locations of this protein?
Nucleus.
Protein: KEFF_ECO8A
Sequence: MILIIYAHPYPHHSHANKRMLEQARTLEGVEIRSLYQLYPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVFSHGWAYGHGGTALHGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefC.  Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefF, Quinone oxidoreductase KefF.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: S1544_SULMK
Sequence: MVDTMNARNTQFTKAFHALKQNAGSHSPSMEDLKKMFPTLEIKIDACYLSNPYASELVLDYIDRELIQTNAYKKVLTHYPSQQRSLQKVMAESLHVKPENIFIGNGATEIIQMLLQQEEVQKVALMIPTFSSYYEFVGKGCEVVYFPLNERDDYSFDADKYCQFIENEQPDTVVLINPNNPNGAYLSLEKMHILLKRLAFVPRIIIDESFIHFAYEDEALTCLSSTVLFDMYPNVIIVKSLSKDFGIAGVRLGYALMDSRKIDALLEHGFLWNINGIGEYCLRLFVREDFLKRYEEARKQYIKEMCRFKEALLGIENVYVYPSMANFVMLKLPSRIKASFVISALLVEYGIYVRTMADKIGVEGECIRIAGRTREENNCIVMALKSILKDSK
What is the function of this protein?
Pyridoxal phosphate (PLP)-dependent decarboxylase involved in the biosynthesis of norcobamides, cofactors in the tetrachloroethene reductive dehalogenase PceA of S. multivorans.  Catalyzes the decarboxylation of L-serine O-phosphate to ethanolamine O-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in norcobamide.  Less active with L-threonine phosphate.  No activity with L-serine or L-threonine.  Has no aminotransferase activity as no production of L-glutamate with L-histidinol phosphate and 2-oxoglutarate as substrates (PubMed:31325159).  Complements growth defects in the S. enterica cobD deletion mutant, but of the cobamides, the norpseudo-vitamin B12 (norpseudo-B12) rather than the pseudo-B12 is produced in the mutant.  However, addition of L-threonine phosphate to the culture minimal medium of the mutant results in formation of also the pseudo-B12, indicating the dual substrate specificity of this enzyme (PubMed:27274028).
What are the official names of this protein?
L-serine phosphate decarboxylase, CobD homolog SMUL_1544, SmCobD, L-serine O-phosphate decarboxylase, L-Ser-P decarboxylase, Norcobamide biosynthesis protein SMUL_1544, Threonine phosphate decarboxylase-like enzyme.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: TSHB_MONDO
Sequence: MTATFLMSLLFGLAFGQTMSLCVPTGYTMHIERRECAYCLTINTTICAGYCMTRDSNGKLFLPKSALSQDVCTYRDVIYRTVVMPGCPPHVIPYISYPVAVSCRCGKCNTDYIDCIHESVTTNYCTKPQKPYLVGFPV
What is the function of this protein?
Indispensable for the control of thyroid structure and metabolism.
What are the official names of this protein?
Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, TSH-B, TSH-beta, Thyrotropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15A_DROYA
Sequence: MVRMNVLADALKCINNAEKRGKRQVLLRPCSKVIIKFLTVMMKHGYIGEFEIVDDHRSGKIVVNLTGRLNKCGVISPRFDVPINDIEKWTNNLLPSRQFGYVVLTTSGGIMDHEEARRKHLGGKILGFFF
What are the official names of this protein?
40S ribosomal protein S15a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NS1_INBHK
Sequence: MADNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPESKRMSLEERKAIGVKMMKVLLFMNPSAGIEGFEPYCMKNPSNSNCPNCNWADYPPTPGKCLDDIEEEPENVDDPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLTIKRDIRNVLSLRVLVNGTFLKHPNGYKTLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERFNEGHSKPIRAAETAVGVLSQFGQEHRLSPEEGDN
What is the function of this protein?
Binds and inhibits the conjugation of the ubiquitin-like G1P2/ISG15 protein to its target proteins.  Since G1P2/ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response.  Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR.  Also binds poly(A) and U6 snRNA.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza B viruses NS1 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: RLMH_HALH5
Sequence: MNISIISVGKLKEKYLKQGIAEYTKRLGAYAKIELIEVPDEKAPEQLSDTEMEHVKQKEGERILAKLHPDTYVIALAIEGSMKSSEELADTMDRLATYGKSKVAFVIGGSLGLSDAVLKRADEKLSFSKMTFPHRLMRLILLEQVYRAFRINRGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
Protein: GPM6A_MOUSE
Sequence: MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFELARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNVWTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTASENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT
What is the function of this protein?
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells.  Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation.  Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways.  Conflictingly, PubMed:22162747 reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a function in actin-independent membrane deformation.  May be involved in neuronal NGF-dependent Ca(2+) influx.  May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
What are the official names of this protein?
Neuronal membrane glycoprotein M6-a, M6a.
What is the protein family that this protein belongs to?
Belongs to the myelin proteolipid protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell projection, dendritic spine. Cell projection, filopodium. Cell projection, neuron projection. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (PubMed:21714103).
Protein: RS9_AYWBP
Sequence: MKKVNYFGTGRRKSSVARVILTNGTGKITINTRDFEKYLPLPATRLEMIQPLELTEKREVFDVSVNVNGGGLSAQAGAIRLGIARALIESIPELRAILKKSGLLTRDARCVERKKYGLKKARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: HBB_LAMGU
Sequence: MVNLSGDEKNAVHGLWSKVKVDEVGGEALGRLLVVYPWTRRFFESFGDLSTADAVMNNPKVKAHGSKVLNSFGDGLSHLDNLKGTYAKLSELHCDKLHVDPENFRLLGNVLVVVLARHFGKEFTPDLQAAYQKVVAGVANALAHRYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RT10_CAEEL
Sequence: MLKLASSLRTGLISRSIRTLAPTVNPAEQQQVQAVLPDKLYSSVEIEYRGHDKAVLKSYTSFLQQVCQHLEIPQGRLEVLPYIRWVQPALRSKFVHKKYKLHYETRTHISKLEILNVTGSTASTFLEYIQRNIPEGVGMRVGFTELQPLPLTIQKN
What is the function of this protein?
Ribosomal protein required for normal mitochondrial function and normal larval development.  Thought to have a role in insulin/IGF signaling.
What are the official names of this protein?
Probable 28S ribosomal protein S10, mitochondrial, MRP-S10, S10mt.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FOXP2_PANTR
Sequence: MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHSIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
What is the function of this protein?
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium.  May also play a role in developing neural, gastrointestinal and cardiovascular tissues.  Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential.  Plays a role in synapse formation by regulating SRPX2 levels (By similarity).
What are the official names of this protein?
Forkhead box protein P2.
What are the subcellular locations of this protein?
Nucleus.
Protein: IGF2B_XENLA
Sequence: MEQLSCKHRSSSMEAEAQLCRQTESRSTQLPRMSVMRHLFLLSITFLVYTLDSAKAYRPTETLCGGELVDTLQFVCGDRGFYFSTNNGRSNRRSNRGIVEECCFRSCDLELLETYCAKPSKNERDVSTAPATAIPPMNKQDLYHKHHHTKSSKYDIWQRKSIHRLRRGVPAIVRARQYRLLMQKAEESEQALLHRPLTTLPITRPLHLQQTSEPSHN
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  Promotes anterior neural development.  Acts as a ligand for integrin which is required for IGF2 signaling.
What are the official names of this protein?
Insulin-like growth factor II-B, IGF-II-B, Insulin-like growth factor 2-B.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.