PharMolix/UniProtQA huggingface dataset:
Protein: ALT4_ALTAL
Sequence: MSVVRPKKVFQTPIDPGVSLRRKKDFYIWAATIGFAQLWRDIKAFKWYRPLQMADLASHYFYIPLGRLDPRILSSAPNDRMLIKTIPHEMSQDYDETGILGCPGREVVNAGSNNYGGFTRFEYGSASVIKLALRNLPFNPAPEELNTLVEREMADYMEADACATAISGYGANLLAFLTVAETAKLSDRQCIFLLDEESHSSMFVGAFLNKEAKFHRFKHNDIADLEYKLRTMKETSPNALVCVAIEGMYSLAGNVAPIPAILALRKVFNFCLLVDEAHSFMAIGCKGRGSFEWWQARGYECPLSEVDIMTATLSKSVGCTGGLVMANKIYASNLQHQARLQREEGDECLSTIVLFRALTLIRKPLFIERRMKTLEEKARYVAERLDEAGCLLLSPPGSPIICFPVGTVQQASNFVAECLKKGFAVACGVPPATPIWSCRVRVCIFATTSWGDILALVNTLIAVSCKLRIDGVQSMKFDTDSLPKVSIKEDIVSDEGNAADLALQEYVEQLAAKYPAEDCRAIAPLNVAQAREVFEYGVQSFEMYGIGASSVRWFYGTFDVFIRLEQRLAGLYPSLISHSGKCRAMLGSDANVMAVSLLSAVAGPMYAKDVLNLVLVPQNAPCYVKKGATLDKVQPSTRVTLYEDLRDLEVEGTKLQKHRYYHVTLYLETVDEDGSILDLSNRIKDILLTLKNAPSLTGLRLILDDSRGLGKIGPRHLGFLDQMESQHGVSFFSTALGPQLAAITTVVVFGSWFHSLNHQGGYVISSEAFTEAHTVSSKSFVFSTPPMIVQAAMSEKTLELLAGGSGLV
What is the function of this protein?
Aminotransferase; part of the gene cluster that mediates the biosynthesis of the host-selective toxins (HSTs) AAL-toxins, sphinganine-analog mycotoxins responsible for Alternaria stem canker on tomato by the tomato pathotype (PubMed:18435561, PubMed:19749175, PubMed:19449880).  The biosynthesis starts with the polyketide synthase ALT1-catalyzed C-16 carbon chain assembly from one starter acetyl-CoA unit with malonyl-CoA extender units (PubMed:18435561, PubMed:19449880).  ALT1 also selectively transfers methyl groups at the first and the third cycle of chain elongation for AAL toxin (PubMed:19449880).  The C-16 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of glycin by decarboxylation, on the carbonyl carbon of polyketide acyl chain (Probable).  This step is probably catalyzed by a pyridoxal 5'-phosphate-dependent aminoacyl transferase ALT4 (Probable).  The respective functions of the other enzymes encoded by the cluster have still to be elucidated (Probable).  The sphingosine N-acyltransferase-like protein ALT7 seems not to act as a resistance/self-tolerance factor against the toxin in the toxin biosynthetic gene cluster, contrary to what is expected (Ref. 5).
What are the official names of this protein?
Aminotransferase ALT4, AAL-toxin biosynthesis cluster protein 4.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: OXYR_STRVD
Sequence: MRKRRRQPSLAQLRAFAAVAEHLHFRDAAAAIGMSQPALSGAVSALEESLGVTLLERTTRKVLLSPAGERLAARAKSVLAEVGALVEEADALQAPFTGVLRLGVIPTVAPYVLPTVLRLVHDRYPRLDLQVHEEQTASLLDGLTGGRLDLLLLAVPLGVPGVVELPLFDEDFVLVTPLEHGLGGREGIPRKALRELNLLLLDEGHCLRDQALDICREAGSAGVAATTTAAGLSTLVQLVAGGLGVTLLPHTAVQVETTRSGRLLTGRFADPAPGRRIALAMRTGAARAAEYEELAAALREAMRDLPVRIVRD
What is the function of this protein?
Required for the induction of a regulon of hydrogen peroxide inducible genes such as catalase and glutathione-reductase.
What are the official names of this protein?
Probable hydrogen peroxide-inducible genes activator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: PIGR_RAT
Sequence: MRLSLFALLVTVFSGVSTQSPIFGPQDVSSIEGNSVSITCYYPDTSVNRHTRKYWCRQGANGYCATLISSNGYLSKEYSGRASLINFPENSTFVINIAHLTQEDTGSYKCGLGTTNRGLFFDVSLEVSQVPEFPNDTHVYTKDIGRTVTIECRFKEGNAHSKKSLCKKRGEACEVVIDSTEYVDPSYKDRAILFMKGTSRDIFYVNISHLIPSDAGLYVCQAGEGPSADKNNADLQVLEPEPELLYKDLRSSVTFECDLGREVANDAKYLCRKNKETCDVIINTLGKRDPAFEGRILLTPRDDNGRFSVLITGLRKEDAGHYQCGAHSSGLPQEGWPVQAWQLFVNEESTIPNSRSVVKGVTGGSVAIVCPYNPKESSSLKYWCHWEADENGRCPVLVGTQALVQEGYEGRLALFDQPGSGAYTVILNQLTTQDSGFYWCLTDGDSRWRTTIELQVAEATKKPDLEVTPQNATAVIGETFTISCHYPCKFYSQEKYWCKWSNDGCHILPSHDEGARQSSVSCDQSSQIVSMTLNPVKKEDEGWYWCGVKEGQVYGETTAIYVAVEERTRGSPHINPTDANARAKDAPEEEAMESSVREDENKANLDPRLFADEREIQNAGDQAQENRASGNAGSAGGQSGSSKVLFSTLVPLGLVLAVGAVAVWVARVRHRKNVDRMSISSYRTDISMGDFRNSRDLGGNDNMGATPDTQETVLEGKDEIETTTECTTEPEESKKAKRSSKEEADMAYSAFLFQSSTIAAQVHDGPQEA
What is the function of this protein?
Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens.  On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.
What are the official names of this protein?
Polymeric immunoglobulin receptor, PIgR, Poly-Ig receptor.
What are the subcellular locations of this protein?
[Polymeric immunoglobulin receptor]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Secretory component]: Secreted.
Protein: RRF_CLOPS
Sequence: MIKDVIKKSEEKMNKTINSLNSELATMKAGRANPTMLDRIQVEYYGSMCPLNQVANVSSPEPRLLVITPWEKPMLKEIEKAILKSDLGINPNNDGTIIRLLVPELTEETRKNLVKNVKKVGEQAKVAIRSIRKDANDKVKNFKKEGTITEDEMKKGEDDIQKVTDKFVKEIDTIVAAKEKEIMSI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSP_ECO57
Sequence: MTQTLSQLENSGAFIERHIGPDAAQQQEMLNAVGAQSLNALTGQIVPKDIQLATPPQVGAPATEYAALAELKAIASRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVASDVHPQTLDVVRTRAETFGFEVIVDDAQKVLDHQDIFGVLLQQVGTTGEIHDYTALISELKSRKIVVSVAADIMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEYKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPIGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAGVLARAEAAEINLRSDILNAVGITLDETTTRENVMQLFSVLLGDNHGLDIDTLDKDVAHDSRSIQPAMLRDDEILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYQQMIAQLADWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLTDLRAKAEQAGDNLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKKASQVAILNANYIASRLQDAFPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESESKVELDRFIDAMLAIRAEIDQVKAGVWPLEDNPLVNAPHIQSELVAEWAHPYSREVAVFPAGVADKYWPTVKRLDDVYGDRNLFCSCVPISEYQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: MURA_XANCP
Sequence: MAKIVVTGGQALHGEVHISGAKNAVLPILCATLLADAPVEISNVPHLHDVITTVKLLSELGAEVTIDEGTLAKGRSILVDPRSVTHQIAPYELVKTMRASILVLGPLLARYGTAEVSLPGGCAIGSRPVDQHIKGLQALGADISVENGYIKATSNGRLKGGRYVFDMVSVTGTENVLMAAVLAEGTTVLENAAMEPEVTDLADCLIALGAQIEGAGTPRITVQGVERLGGGHHAVLPDRIETGTFLVAAAMTGGSVTVRRARPDTLDAVLDKLTEAGATITTTADSVTLDMHGKRPRAVNLTTAPYPAFPTDMQAQFMALNCVADGVGVINETIFENRFMHVNELLRLGADIQVEGHTAIVRGAERLSGAPVMATDLRASASLILAGLVADGDTTIDRIYHLDRGYENIEEKLGALGATIRRIA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL92_SHV21
Sequence: MSTHQCQFNKLNTVVCQYHKVFCLYQCCQCKKYHICDGSKTCILINTGESLVCTLTGNCIFNNFQENTFLKQDNIKESKQQFDFTLFANILESLKQDLENYFIKSYGLEEVSKAILDNNSLKPEICDLIRCTFQHCCHIFGEIQYGYDIICSMYIHIIISIYSTRTVYGNLLFKCTKNKKYDYILKRMRETWMSTLITGDSCQDQIKS
What are the official names of this protein?
Gene 31 protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL92 family.
Protein: MENC_SALTY
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLRDGEREGWGEISPLPGFSQETWEEAQTALLTWVNDWLQGSEGLPEMPSVAFGASCALAELTGVLPEAADYRAAPLCTGDPDDLVLRLADMPGEKIAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKAQQFAKYVNPDYRARIAFLEEPCKTRDDSRAFARETGIAIAWDESLREADFTFEAEEGVRAVVIKPTLTGSLDKVREQVAAAHALGLTAVISSSIESSLGLTQLARIAAWLTPGTLPGLDTLHLMQAQQIRPWPGSALPCLKREELERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: PYRF_VIBC3
Sequence: MNDPKVIVALDYDNLADALAFVDKIDPSTCRLKVGKEMFTLFGPDFVRELHKRGFSVFLDLKFHDIPNTCSKAVKAAAELGVWMVNVHASGGERMMAASREILEPYGKERPLLIGVTVLTSMESADLQGIGILSAPQDHVLRLATLAKNAGLDGVVCSAQEASLLKQHLGREFKLVTPGIRPAGSEQGDQRRIMTPAQAIASGSDYLVIGRPITQAAHPEVVLEEINSSLV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: RL6_BRUSU
Sequence: MSRIGKKPVPVPAGVTASVEGQTVKAKGAKGELSFVVHDEVLVKMEDGAVRVDPRDQSKEARSKWGMSRTMISNIFVGVKDGFEKKLEISGVGYRAAMQGKNLQLSLGFSHEVVYDVPAGITVAVPKPTEIVVTGIDKQQVGQVAAEIREYRGPEPYKGKGVKYAGEKIVRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: FDL23_ARATH
Sequence: MEQGESLRIRVVMGKDRISELPDALLIKILSFLPTKIVVATSVFSKQWRPLWKLVPNLEFDSEDYDDKEQYTFSEIVCKSFLSHKAPVLESFRLEFESEKVDPVDIGLWVGIAFSRHLRELVLVAADTGTGTAFKFPSSLCTCNTLETLRLVLLILVDISSPVVMKSLRTLHLELVSYKDESSIRNLLSGCPILEELLVIRGEDSDIEVFTIDEVPSLKRLTINDDHDGQEFWGYVINAPSLKYLLIEDLRCPGFCLNAPELMEANIFDGTSITNDNFLGYLTSVKRLLLNLSPWKITYPTGSIFYQLVSLEMYTREIDWWDLLTLMLEHSPKLQVLKLTDNCVKFHKNGLPGGKWNEPKYVPECLLSHLETFVWRRFDWGREEEKEIATYILKNARRLNKATFSTNPVNSEELDKLKERRKVHNELDGVVRASNSCQFVFKFDTSYHVSDSS
What are the official names of this protein?
F-box/FBD/LRR-repeat protein At4g00160.
Protein: RNPH_ACIBC
Sequence: MRIDQRALDQLREVKITRNYTRYAEGSVLVEFGHTKVLCTASIDNSVPRFLKGQGQGWVTAEYGMLPRSTHSRCDREAARGKQTGRTQEIQRLIGRSLRAMVDLKKLGENTITIDCDVIQADGGTRTASITGAAVALVDAMNVLLAQKKIKQDPLKGLVAAISVGMYQDEVLLDLCYEEDSNCQTDLNVVMTQAGEFIEIQGTAEDKPFTRAQSNAMLEMAEKGIAELIKKQQEALGW
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: XYLA_PSEU2
Sequence: MPYFPDVDRVRYEGPDSDSPLAFRHYDADKLVLGKPMREHLRMAACYWHTFVWPGADMFGVGTFKRPWQGSGDPMELAIGKAEAAFEFFSKLGIDYYSFHDTDVAPEGASLKEYRHNFAHMVDHLERHQQQSGIKLLWGTANCFSNPRFAAGAASNPDPEVFAYAATQVFSAMNATQRLKGSNYVLWGGREGYETLLNTDLKREREQLGRFMRMVVEHKHKIGFKGDLLIEPKPQEPTKHQYDYDSATVFGFLQQYGLENEIKVNIEANHATLAGHSFHHEIATAVSLGIFGSIDANRGDPQNGWDTDQFPNSVEEMTLATYEILKAGGFTNGGFNFDSKVRRQSLDDIDLFHGHVAAMDVLALALERAAAMLQNDKLQHFKDQRYAGWQQPFGQSVLAGEFSLASLAEHAFANELNPQAVSGRQELLEGVVNRFIYA
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_HAHCH
Sequence: MKSSEIRSAFLKYFQRNGHEVVASSSLVPADDPTLLFTNAGMNQFKDVFLGKDKRNYDRATTSQKCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKREAINYAWEFLTSSDWLNIDKSKLTVTVYASDDESFDIWANEIGVPEERIIRIGDNKGAPYASDNFWQMGDTGPCGPCTEIFYDHGPHIAGGPPGSPDEDGDRFIEIWNVVFMQFNRTADGEMHPLPKPSVDTGMGLERISALMQGVHSNYEIDLFQELLAEASKVLGGASIEEPALRVIADHIRSSSFLIADGVLPENIGRGSVLRRIIRRAARYGNKVGATEPFLHKLVGKLVELMGDAYPELKASQNKIEKTLLLEEEQFAKTLDKGLKLLEHELEQLKGMTIPGKTIFTLYDTYGFPVELTNDIARERSLAMDMDGYEVEMEAQRKRAREAGSFGVDYNAGLNIDVSSEFTGYTELAGSYKALALFAGSDKADALTVGQQGLVVLDKTPFYAESGGQVGDTGVLKTDTGVFVVKDTKKEGAAIVHIGAVSEGEIKVGQTVTAEVDRHKRKATALNHSATHLLHAALRKVLGDHVAQKGSLVDPERLRFDFAHFEPMTQEQIRQVESIVNAQIRANTSVSTEVMGMDAARERGAMALFGEKYGDTVRVLAMGESDFSIELCGGTHVERTGDIGMFVIASEAGTAAGVRRIEALTGQPAENWVQSSDALLRDIAVLVKGNRETAADKVRALIERSRQLEKEVDQVKAKLASSAGSDLAASAVDVKGLKVLAAKLDGVDRKALMDTVDQLKNKLGQAVVLLASVEDGKASIVAGVTKAESAKVKAGDLVKMVAEQLGGKGGGRPDMAQGGGVELGKLDAALASVNAWVEGQLG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VHL_DROME
Sequence: MALQIAQNNRDGQQLVGADQGKVEVYVLFANTTYRTLDLYWVCERERENMYLTLKPFEEVRVNTFTTHSWLFRDYYTGERMHVRSQRIFQPIRVRVPKSQQSPDQLVDVRSEVLIHFPMRSLRENCLWLVARWLIRTSNAPRRIIHGYHIPSTLKQQLLSLLTCIESYSRVAGTRRRR
What is the function of this protein?
Involved in development of tracheal vasculature.  Probably involved in halting cell migration at the end of vascular tube outgrowth.  Possesses E3 ubiquitin ligase activity when in complex with Elongin BC complex, Cul2 and Rox1a/Rbx1, and can target sima/Hif1a for ubiquitination.  May play a critical role in promoting microtubule stabilization when tubulins are correctly folded by the prefoldin complex.  If tubulin is incorrectly folded, may promote its degradation.
What are the official names of this protein?
Protein Vhl.
What is the protein family that this protein belongs to?
Belongs to the VHL family.
Protein: RS3A_ANOGA
Sequence: MAVGKNKGVSKGGKKGSKKKVVDPFTRKDWYDVKAPNMFKNRQVGKTLVNRTQGTKIASDGLKGRVFEVSLADLQNEPDAERSFRKFKLVAESVNGRDVLTNFHGMALTTDKLRSMVKKWQTLIECSVDVKTTDGFMLRVFCIGFTIKDSMSQRKTCYAQHSQIKNIRAKMTAIIKREITSTDLKGVVEKLLPDSIAKDIEKACQVVYPLHDVYIRKVKVLKKPRFDLSSLMELHGDGGGKAAEVSTGAASGVVVDRPEGYEPPVQASV
What is the function of this protein?
Has an essential role in oogenesis.
What are the official names of this protein?
40S ribosomal protein S3a, C3 protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MODSP_DROME
Sequence: MQLISFLSNPLFFCALLLKFRTIFAACDSSQFECDNGSCISQYDVCNGEKNCPDGSDETALTCVSQRQHCTKPYFQCTYGACVIGTAGCNGVNECADGSDETRLRCGNEDDIRQHDRRLQGNCKENEFKCPSGICLDKSNFLCDGKDDCADGTGFDESVELCGHMECPAYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLGCPLPLGDERPILTGDGSRVLTGPITRGTVRFSCKQGYVLEGEESSYCAKNKWSTSTIPKCVKYCSTAGEFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTGFKTLSPLPEMRCMKGGYWNRGRQRCEQDCGQLATPIKQFSSGGYTINNTVVPWHVGLYVWHNEKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYDTFRVIAAKFYRNYGETTPEEKRRDVRLIEIAPGYKGRTENYYQDLALLTLDEPFELSHVIRPICVTFASFAEKESVTDDVQGKFAGWNIENKHELQFVPAVSKSNSVCRRNLRDIQADKFCIFTQGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFGVISNAPNADQCAHSLTVMTNIQHFEDMILNAMNRSVETRS
What is the function of this protein?
Serine protease that plays a key role in innate immunity by activating the Toll pathway in response to infection with Gram-positive bacteria and fungi (PubMed:19590012, PubMed:24794300).  During Gram-positive infection, acts downstream of PGRP-SA and upstream of Grass and Spz, and therefore appears to function in a pathway that links detection of Gram-positive lysine-type peptidoglycans to Toll activation (PubMed:19590012).  Functions in a separate pathway to the psh-mediated activation of the Toll pathway (PubMed:19590012).
What are the official names of this protein?
Modular serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted. Note=Localizes at the membrane of lipid vesicles. Secreted from the fat body into the hemolymph at the surface of these lipid vesicles.
Protein: Y2115_VIBVU
Sequence: MLRVLGLAGMLMSFNIHAAMISPVSGVKILFANGTEVDEPLEPMEVDAKSAQLVVRYAAELGSGSNQKVFDSAPFVITIDNLSEDIKLYPPKVFSYEQANREFNTSPKWRIEGVSGKEISYSQEKLKGNEGFMPYYGMEALIAKHNEERGIVFSAGVVKAEVVTTDKMVEKPATTKNADALVQLQHWYKQASTEERKAFRKWMVDQE
What are the official names of this protein?
UPF0319 protein VV1_2115.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: NADK_BORBR
Sequence: MYFPIVALIGRYQDTGLDAPLTALAQMLTQAGRRVLVEAETARNAGVSGYPVADWDEIGRTATLAVVMGGDGTVLGAARHLAPYGVPLIGINHGRLGFITDIPLQDAHDALGRVLEGNYQAEDRMLLQGGVWRGEQQMYSASAVNDVVLNRAGRGGMIEVRVELDGAFMYTQRADGLIIATPTGSTAYSLSANGPILHPGMNAMVLVPVAPQTLSNRPIVIPDSGVLNMTLTAMGRVEIGASVHFDMQTWSDLQPGDRITVQRAPHTIRFVHPEGYSFFSTLRRKLHWNLMPQATDNLE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STAT3_BOVIN
Sequence: MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQLLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLLDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTCLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEDAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEAAEPSAGGQFESLTFDMELTSECATSPM
What is the function of this protein?
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors.  Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene.  May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.  Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes.  Activated by IL31 through IL31RA (By similarity).  Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity).  Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity).  Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation.  May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity).  Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity).  Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion.  Plays an important role in host defense in methicillin-resistant S. aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
What are the official names of this protein?
Signal transducer and activator of transcription 3.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus (By similarity). The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3.
Protein: MSP55_CAEEL
Sequence: MAQSVPPGDIQTQPGTKIVFNAPYDDKHTYHIKVINSSARRIVYGIKTTNMKRLGVDPPCGVLDPKEAVLLAVSCDAFAFGQEDTNNDRITVEWTNTPDGAAKQFRREWFQGDGMVRRKNLPIEYNP
What is the function of this protein?
Central component in molecular interactions underlying sperm crawling.  Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
What are the official names of this protein?
Major sperm protein 55/57, MSP.
What are the subcellular locations of this protein?
Cell projection, pseudopodium. Cytoplasm, cytoskeleton.
Protein: SCX2_RHOJU
Sequence: KEGYPMGRDGCKISCVINNNFCKVECQAKWRQSDGYCYFWGLSCYCTNLPEDAQVWDSSTNKCGG
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Putative beta-neurotoxin RjAa2.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LE756_CAEEL
Sequence: MAVPAASSIVSYGGAATSNFLTTPVTPFLAGFYNSNFVTDRINSCAPYRVDRIRKQLQDEEENGYPPADDRRRGALFCRSGTWLEMLPIENPDDGSTRVKVHGTKEESSKFSIVEFVSVAMSLVSIRGVETKNFICMDPSGKLYATPSSNYSTECVFLEEMMENYYNLYASCAYGDRFNPWYIELRRSGKPRRGPNSKKRRKASHFLVVHHDLDRLRSPVPNGNDVTDLVVASLFHQPPSHPLFRQQTVTKPPNPHRISNLRAKVEMTNQAEKQRLLEEKKRRREKKKRRREDRLRKEEQIREARRQELKSLREEELRRRYQQQQQQQASTQTRYNRPQNPANPYPTYRPLPTRSTVQSPRPAYNPYWQSPVTQAPHHNSHHHHHHHPRVSSSSDPQQRHQSQQHYLAQTVSNPNRQNVNYQRYP
What is the function of this protein?
Required for larval development (PubMed:9331368).  Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development (PubMed:16495308).
What are the official names of this protein?
Protein let-756, Lethal protein 756.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Nucleus. Membrane; Peripheral membrane protein.
Protein: YE078_YEAST
Sequence: MVRLSYLRLILPPCRLSELSSLAILYQPVIPILISTITFQHFFKCVHTPCNVYI
What are the official names of this protein?
Uncharacterized protein YER078W-A.