PharMolix/UniProtQA huggingface dataset:
Protein: ACSL3_MOUSE
Sequence: MNNHVSSTPSTMKLKQTINPILLYFIHFIISLYTILTYIPFYFLCESKQEKPNQIKAKPVSSKPDSAYRSINSVDGLASVLYPGCDTLDKVFMYAKNKFKNKRLLGTREILNEEDEIQPNGKIFKKVILGHYNWLSYEDVFIRALDFGNGLQMLGQKPKANIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHGLNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGVIVHTMAAVQALGVKANVEKKAHSKPLPSDIAVIMYTSGSTGIPKGVMISHSNIIASITGMARRIPRLGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSVLKPTLMAAVPEIMDRIYKNVMNKVNEMSAFQRNLFILAYNYKMEQISKGCSTPLCDRFVFRNVRRLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESTGAGTITEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQNVTMGYYKNEAKTKTDFFEDENGQRWLCTGDIGEFDPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLIDNICAYANSYHSYVIGFVVPNQKELTELARTKGFKGTWEELCNSSEMENEVLKVLSEAAISASLEKFEIPLKIRLSPDPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
What is the function of this protein?
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity).  ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity).  Has mainly an anabolic role in energy metabolism.  Mediates hepatic lipogenesis.  Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates.  Both isoforms exhibit the same level of activity (By similarity).
What are the official names of this protein?
Fatty acid CoA ligase Acsl3, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 3, LACS 3, Long-chain-fatty-acid--CoA ligase 3, Medium-chain acyl-CoA ligase Acsl3.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: MIAB_SALHS
Sequence: MTKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWRLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGTFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRVLNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTDDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKNIMELSGRTENNRVVNFEGTPEMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENELGVGFYQP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPB_SALTI
Sequence: MSRKQLALFEPVLLVQALTDAVKKLSPRAQWRNPVMFVVWAGSVLATLLTLAMVTGQIAGSALFTGVISLWLWFTVLFANFAEALAEGRSKAQANSLKGVKKTAFARRLRAPRHDAQADNVPAAELRKGDIVLVKAGDIIPCDGEVIEGGASVDESAITGESAPVIRESGGDFASVTGGRAVEAAGDVDVLLLDKTGTITLGNRQASDFIPARGVDERTLADAAQLASLADETPEGRSIVILAKQRFNLRERDVQSLHATFVPFTAQSRMSGINIDNRMIRKGSVDAIRRHVESNGGHFPADVEQNVENVARLGATPLVVVEGARVLGVIALKDIVKGGIKERFAQLRKMGIKTVMITGDNRLTAAAIAAEAGVDDFLAEATPEAKLALIRQYQAEGRLVAMTGDGTNDAPALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLIEVVHIGKQMLMTRGSLTTFSIANDVAKYFAIIPAAFAATYPQLNALNVMGLHSPNSAILSAVIFNALIIIFLIPLALKGVSYKPLSASAMLRRNLWIYGLGGLVVPFIGIKVIDVLLTLLDLA
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Putative potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENTH_ECOLU
Sequence: MIWKRHLTLDELNATSDNTMVAHLGIVYTRLGDDVLEAEMPVDNRTHQPFGLLHGGASAALAETLGSMAGFMMTRDGQCVVGTELNATHHRPVSEGKVRGVCQPLHLGRQNQSWEIVVFDEQGRRCCTCRLGTAVLG
What is the function of this protein?
Required for optimal enterobactin synthesis.  Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.
What are the official names of this protein?
Proofreading thioesterase EntH, Enterobactin synthase component H.
What is the protein family that this protein belongs to?
Belongs to the thioesterase PaaI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NED4L_HUMAN
Sequence: MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:31959741, PubMed:33608556, PubMed:20064473).  Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141).  Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741).  Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1. 2, SCN3A/Nav1. 3, SCN5A/Nav1. 5, SCN9A/Nav1. 7, SCN10A/Nav1. 8, KCNA3/Kv1. 3, KCNH2, EAAT1, KCNQ2/Kv7. 2, KCNQ3/Kv7. 3 or CLC5 (PubMed:26363003, PubMed:27445338).  Promotes ubiquitination and degradation of SGK1 and TNK2.  Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).  Plays a role in dendrite formation by melanocytes (PubMed:23999003).  Involved in the regulation of TOR signaling (PubMed:27694961).  Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338).  Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556).
What are the official names of this protein?
E3 ubiquitin-protein ligase NEDD4-like, HECT-type E3 ubiquitin transferase NED4L, NEDD4.2, Nedd4-2.
Protein: RL23_YEREN
Sequence: MIREERLLKVLRAPHVSEKASAAMEKNNTIVLKVAKDATKAEIKAAVQKLFEVEVEDVNTLLVKGKSKRHGQRVGRRSDWKKAYVTLKEGQNLDFIGGAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: SUCC_CHRVO
Sequence: MNLHEYQAKELLSRYGLPVQQGILAKSPEEAAAAYDKLGGKFAVVKAQVHAGGRGKAGGVKVVKSREEAAEVAKTLIGTNLVTYQTDAAGQPVNSVLVCEDMYPVQRELYLGAVVDRGSQRVVFMVSTEGGVEIEKVAEETPEKIIKIEVDPLVGMQPFQARDAAFALGLSGAQVAAFSKLMLGSYQAFIENDFALFEVNPLALRENGELACVDGKINLDSNALYRHPELLAQRDKSQENEREVKASEFDLNYVALEGNIGCMVNGAGLAMATMDIIKLKGGQPANFLDVGGGATKERVIEAFKLILADTSVQGVLINIFGGIVRCDMIAEAIIAAVKEVNVTVPVVVRLEGNNAELGAKILDESGLKLTSAQGLNDAAEKIVAAVKAVA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: TBB2B_RAT
Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:19465910).  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.  Plays a critical role in proper axon guidance in both central and peripheral axon tracts.  Implicated in neuronal migration (By similarity).
What are the official names of this protein?
Tubulin beta-2B chain, T beta-15.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: BIOD_NEIG1
Sequence: MKGVYFVSGIDTDIGKTVATGMLAKQLLQQGKSVITQKPVQTGCQDIAEDIAVHRKIMGIPMQEADEQRLTMPEIFSHPASPHLAARLDGRGLDLDKIRTATQELAAQYEVVLVEGAGGLMVPLTEKLLTIDHIQQQAYPVILVTSGRLGSINHTLLSFVVLKQYGIRLHSLVFNHIHDSRDAHVAQDSLNYLQCRLKADFPEAEWMELAKTGAV
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBCEL_RAT
Sequence: MDQPSGRSFMQVLCEKYSPENFPYRRGPGMGVHVPATPQGSPMKDRLNLPSVLVLNSCGITCAGDEREIAAFCAHVSELDLSDNKLQDWHEVSKIVSNVPQLEFLNLSSNPLSLSVLERTCAGSFSGVRKLVLNNSKASWETVHTILQELPDLEELFLCLNDYETVSCPSVCCHSLKLLHITDNNLQEWTEIRKLGVMFPSLDTLVLANNHVNAIEEPADSLARLFPNLRSISLHKSGLQSWEDIDKLNSFPKLEEVRLLGIPLLQPYTTEERRKLVVARLPSVSKLNGSVVTDGEREDSERFFIRYYVDVPQEEVPFRYHELITKYGKLEPLAEVDLRPQSSAKVEVHFNDQVEEVSIRLDQTVAELKRQLKTLVQLPTSSMLLYYFDHEAPFGPEEMKYSSRALHSFGIRDGDKIFVESKTK
What is the function of this protein?
Acts as a regulator of tubulin stability.
What are the official names of this protein?
Tubulin-specific chaperone cofactor E-like protein, Leucine-rich repeat-containing protein 35.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: URE2_GLOC7
Sequence: MIPGEIITLPEDQEIILNAGRPTLDIMVSNKGDRPIQVGSHYHFLEVNEDLEFYEIDSESKNFIFIDRSNLHNKTRGMRLNIPAGTAVRFEPGDIKKVQLVPLAGTREIYGFNGKINGQLDSSVEQ
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPIE_PONAB
Sequence: MATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETEKHRGFAFVEFELAEDAAAAIDNMNESELFGRTIRVNLAKPMRIKEGSSRPVWSDDDWLKKFSGKTLEENKEEEGSEPPKAETQEGEPAAKKARSNPQVYMDIKIGNKPAGRIQMLLRSDVVPMTAENFRCLCTHEKGFGFKGSSFHRIIPQFMCQGGDFTNHNGTGGKSIYGKKFDDENFILKHTGPGLLSMANSGPNTNGSQFFLTCDKTDWLDGKHVVFGEVTEGLDVLRQIEARGSKDGKPKQKVIIADCGEYV
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome.  Combines RNA-binding and PPIase activities.  Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules.  Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.  Inhibits KMT2A activity; this requires proline isomerase activity.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase E, PPIase E, Cyclophilin E, Rotamase E.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: P20D2_HUMAN
Sequence: MRPGGERPVEGGACNGRSELELLKLRSAECIDEAAERLGALSRAIWSQPELAYEEHHAHRVLTHFFEREPPAASWAVQPHYQLPTAFRAEWEPPEARAPSATPRPLHLGFLCEYDALPGIGHACGHNLIAEVGAAAALGVRGALEGLPRPPPPVKVVVLGTPAEEDGGGKIDLIEAGAFTNLDVVFMAHPSQENAAYLPDMAEHDVTVKYYGKASHSASYPWEGLNALDAAVLAYNNLSVFRQQMKPTWRVHGIIKNGGVKPNIIPSYSELIYYFRAPSMKELQVLTKKAEDCFRAAALASGCTVEIKGGAHDYYNVLPNKSLWKAYMENGRKLGIEFISEDTMLNGPSGSTDFGNVSFVVPGIHPYFHIGSNALNHTEQYTEAAGSQEAQFYTLRTAKALAMTALDVIFKPELLEGIREDFKLKLQEEQFVNAVE
What is the function of this protein?
Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.  Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis.
What are the official names of this protein?
Xaa-Arg dipeptidase, Beta-Ala-Lys dipeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
Protein: VSP_BOTIN
Sequence: MVLIRVIANLLILQVSYAQKSSELVVGGDECDINEHPFLAFLYSHGYFCGLTLINQEWVLTAAHCDRRFMRIYLGIHARSVANDDEVIRYPKEKFICPNKNMSDEKDKDIMLIRLNRPVKNSTHIAPISLPSNPPSVGSVCRVMGWGSITIPNDTYPDVPHCANINLVNDTVCRGAYKRFPAKSRTLCAGVLQGGKDTCVGDSGGPLICNGTFQGIVSWGGKVCARPRKPALYTKVFDYLPWIQSIIAGNKTATCPP
What is the function of this protein?
Snake venom serine protease that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine protease BITS01A, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PAP2_PARPV
Sequence: GFFALIPKIISSPIFKTLLSAVGSALSSSGGQE
What is the function of this protein?
Exhibits unusual shark repellent and surfactant properties.  Forms voltage-dependent, ion-permeable channels in membranes.  At high concentration causes cell membrane lysis.
What are the official names of this protein?
Pardaxin P-2, Pardaxin Pa2.
What is the protein family that this protein belongs to?
Belongs to the pardaxin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: SFH5_ASPTN
Sequence: MSEQEKTPPAAAEPQPPVDNKPTDAPAQPEHPPTDGNDKTEQPATEAAPAEAPTEQPKQDDAAQPADNKPDYLAKNPALSEFFDRLPAILSSAGHNEMWGVTLRDSADVPTVNVMIKFLRANEGNVKQAEDQLIKALQWRKEMDPTALVDTASYSASKFGGLGYLTTYQDANGKETVVTWNIYGAVKKIDETFGNMDEFLKWRVALMEMAVKELKMDQATTVMDYNADEDPYQMLQVHDYLNVSFLRINPNLRAATKKTIEVFAMAYPELLREKFFVNVPAIMGWMFAAMKVFLSKNTTRKFHPISNGANLAREFPSPLKDQFPKAYGGNGPALQDNARTVNLVADPEPAQEASKDEAQEAPKDAPKEEPKEEPKEEPKEEPKEEPKEEPKEESKAETTQESADAPEKNDAAVTEAPAPAAEAK
What is the function of this protein?
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity.  Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.  Heme-binding protein that may play a role in organic oxidant-induced stress responses.
What are the official names of this protein?
Phosphatidylinositol transfer protein sfh5, PITP sfh5.
What is the protein family that this protein belongs to?
Belongs to the SFH5 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: RSMH_RHIEC
Sequence: MVTNPGGGSTDAGGGPVRHIPVLLNEVLAALSPAPGKLILDGTFGAGGYSAAILAAGAEVIALDRDPSAIAAGQAMVAAHAGRLRLIHAQFSNLGDHAPQGGLDGVVLDIGVSSMQIDEPERGFSFQKSGPLDMRMSATGVSAADVVNRAKVADLIRIFHFLGEENQAPRIAHAIEKRREEKPFETTRDLAGLIELVTPRKMKDKIHPATRVFQALRIFVNDELGELAQALFAAERTLKPGGRLVVVTFHSLEDRIVKKFFSDRAGRATGSRHLPAAHERAATFTAIGKPMVSASEAEAEANPRARSAKLRAGLRTDAAAEAADMSLFGFPNLASLGKLGG
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURQ_VIBA3
Sequence: MSNDALISALSHLVSEGRNPDTMDIDLLTSLEVVEKINQQDKQVPLAIEAELPQIAKAVDKIAQAFQNGGRLIYMGAGTSGRLGVLDASECPPTFGVSDKMVIGLIAGGPEAILKAKEGAEDSLTLGIEDLKAIQFSENDVVVGIAASGRTPYVIGALNYANQLGAVTVALSCNPDSPIAEIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRIGKSYQNLMVDVKATNEKLVARAARIVIQATECEKALAVSTLKATDYDVKLSILMILTGLDLELAKAQLDKQNGFLRKAVENNQ
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: FKB2A_RHIO9
Sequence: MFSHVICKFLLTLSFITIIYAAKSESTINKPEKCGLKASSSSTVRIHYRSRVWGQEEYFESTYIREAPLEVKLGNGNLLKGIEDGIHGMCTGEIRRLLIPPNQAYGAIGIPNLVPPNTAIVVDVEMVNVNSPFSLWFWISGLILFSAFLLFGRKPIKGDTSNIKKKE
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
FK506-binding protein 2A, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SSRP_STRP7
Sequence: MAKGEGKVVAQNKKARHDYTIVDTLEAGMVLTGTEIKSVRAARINLKDGFAQVKNGEVWLSNVHIAPYEEGNIWNQEPERRRKLLLYKKQIQKLEQETKGTGMTLVPLKVYIKDGYAKLLLGLAKGKHDYDKRESIKRREQNRDIARVMKAVNQR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: NU4C_PROM1
Sequence: MLIPEPIQADFPWLSLSILFPIVGALIVPFIPDKGEGKEVRWYALIISLITFLITVAAYFKGFDPSLEGLQLYEKVSWLPDLGLTWSVGADGLSMPLILLTSFITSLAVLAAWPVSYKPKLFFFLILAMDGGQIAVFAVQDMLLFFLAWELELFPVYLFLAIWGGKKRQYAATKFIIYTAGSSLFILLAGLAMGFFQGGGVPDFGYTHLAQQNFGRGFQLLCYSGLLIAFGVKLPIVPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPDAHAQFAPLLIVLGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGATYDRTHTLQLDEMGGIGQNMRIMFALWTACAFASLALPGMSGFISELMVFVGFVTDEVYTLPFRIVVASLAAIGVILTPIYLLSMLREIFFGKENAKLISKAKLVDAEPREIYIIACLLVPIIGIGLYPKIMTDTYISSIDGLVKRDLLAVERIRSDRATIMSNTSLSIGTIEAPLLD
What is the function of this protein?
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, NAD(P)H dehydrogenase I, chain 4, NDH-1, chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: TB1RB_XENLA
Sequence: MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQQAAAAAAAAAAAAAATSANNQQPPAKNGESTANGEENGGHALANNHTDMMEVDGDVEIPPSKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKHDTCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK
What is the function of this protein?
F-box-like protein which acts as an integral component of the N-CoR transcriptional corepressor complex.  Probably regulates transcription activation mediated by nuclear receptors.  May mediate the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of the N-CoR complex, thereby allowing cofactor exchange and transcription activation (By similarity).
What are the official names of this protein?
F-box-like/WD repeat-containing protein TBL1XR1-B, Nuclear receptor corepressor/HDAC3 complex subunit TBLR1-B, TBL1-related protein 1-B, Transducin beta-like 1X-related homolog 1-B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EBI family.
What are the subcellular locations of this protein?
Nucleus.