PharMolix/UniProtQA huggingface dataset:
Protein: CC174_HUMAN
Sequence: MDRRKKPLDVTASSLVDLKAELFRKQEEFKQEKLLKDSGVFGKPKTTNKKPSIWSKQNVGVSNRAEKDAEQKIEEQKTLDKAREKLEEKAKLYEKMTKGDFIDEEVEDMYLVDFTQKIIDKRKEMEASGAHRDSQKAGERDDDEENLPEGEIPPPQDPSEEWVDYVDSLGRSRRCMRKDLPDLLEMDKNLQGRLFISPANEKTLLSEDMRKELQRQQWEEEEREALKRPMGPVHYEDIRENEARQLGVGYFAFARDKELRNKQMKTLEMLREQTTDQRTKRENIKEKRKAILEARLAKLRQKKMKKSKEGGTEEENRDGDVIGPLPPEPEAVPTPRPAAQSSKVEVIVQERKDTKPGVPHIREWDRGKEFSFGYWSKRQSDLRAERDPEFAPPSDYFVGQKRTGFSSSQAWSRPGPAQSDPGQCPDQSHGPSPEHTSPTPAPDNPPQAPTVTFKTLDDMISYYKQVT
What is the function of this protein?
Probably involved in neuronal development.
What are the official names of this protein?
Coiled-coil domain-containing protein 174.
What are the subcellular locations of this protein?
Nucleus. Note=In the nucleus of neuroblastoma cells, it colocalizes with EIF4A3, a component of exon junction complex.
Protein: GLMM_SALPB
Sequence: MSNRKYFGTDGIRGRVGNAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSASFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDDVEEAIEAEMEKEITCVDSAELGKASRIVDAAGRYIEFCKGTFPNELSLNGLKVVVDCANGATYHIAPNVLRELGATVIAIGCEPNGVNINEEVGATDVRALQARVLAEKADLGIALDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKLQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMVRNHMSLHDLCSGMKMFPQILVNVRYTAGSGDPLENEAVKAVTADVEATLGNRGRVLLRKSGTEPLIRVMVEGEDEAQVTAFAHRIADAVKAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RSMH_BARQU
Sequence: MTKPGNKAERHIPVLLQPVLAGLMPLIGAKVIDGTFGAGGYTRALLNAGAQVIALDRDPHAVREGQSLVDEFFPRLRLMQMEFSQLDRVVEEKVDAVILDIGVSSMQFDEAERGFSFQKDGPLDMRMAQTGFTAGDVVNRLKKDDLARIFKILGEERYAGRIARMIEKRRCVQPFLRTGDLAHAIEALVGRKPGDRIHPATRVFQALRIYVNDEIGELARGLFAAESVLKPGGRLGVVSFHSLEDRMVKRFFSARSGGCRRSRYLPEIEAVPATFFSLFKGAITASKEELQQNPRSRSARLRIGIRTEAECLAKDIKLFDFAEIASFEGSKK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_ALCBS
Sequence: MTVPRVKICGITRIEDGLAAANAGADAIGLVFYGPSPRAVTARQAAEICASLPPFVTTVALFVDASRAEIEGVLARVPVDLLQFHGNENPQFCDSFNRPWIKAVRMKDDVDLHHYAQIYRNAAGLLIDSYVAGVPGGTGETFNWGRVPKTLPLPVVLAGGLHPGNVAAAVTQVQPWAVDVSGGVEQKNVQGGRSGGIKDASAIRVFINSVKTRGVAGV
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RS11_RICFE
Sequence: MNQTVKVKKKKKTITLGVVHIRASFNNTIVTFTDIQGNTISSASAGGNGFKGARKATPYAAQVTIDRASEKAKEYGLKTISIRIGGPGAQRESAMRALFGQNFVVTSILDVSSIAHNGVRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: QUEF_RUEPO
Sequence: MANQDIYANLTQLGGKTELPNSPEEAVLEKVPNPQAGTDYAVRFTAPEFTSLCPLTAQPDFAHIVIDYVPGDWLVESKSLKLYLGSFRNHGAFHEDCSVSIGKRLVELLAPKWLRVGAYWYPRGGIPIDVFYQTGPELPGVWIPDQGVPTYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA12_CONBN
Sequence: KECCTHPACHVSHPELCG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity).  Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity).
What are the official names of this protein?
Alpha-conotoxin-like Bn1.2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MNMA_STRE4
Sequence: MMTDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDTDEFGVCTATEDYKDVAAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRSGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYAQIKRDENGVVHMLRGLDKGKDQTYFLSQLSQEQLQKTMFPLGHLQKSEVRAIAEQAGLATAKKKDSTGICFISEKNFKTFLSHYLPAQKGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQQGGDNKPWFVVGKDLSQNILYVGQGFYHESLMSTSLDASVIQFTREVPEEFTLECTAKFRYRQPDSKVTVHVKKDKAKVVFAEPQRAITPGQAVVFYDGHECLGGGIIDMAYKDGEPCQYI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YD338_YEAST
Sequence: MAGILSKTLSEVHPSLRTNGMGIGNTHRRISLGFLPPNKKNPLVRKFRARTRNIDQRSFRSLTDDFGSNVHEPNPYLGNIDEEPDLYYHDEEDGELSRTISLPSRVSETPELSPQDVDWILHEHERRYSSVCNSDNEEASQSNTPDRIQEYSGRELEYDEFMNRLQAQKQKLTRSAVTDAKGTSHHRRPSFVSVTSRGSVPTIYQEIDENDSEALAELAHSHVTFKSEARVLASYSFPLIFTFLLEQIFPMVCSLTVGHLGKNELAAVSLASMTSNITLAIFEGIATSLDTLCPQAYGSGRFYSVGVHLQRCIAFSLVIYIPFAVMWWYSEPLLSYIIPEKELINLTSRFLRVLILGAPAYIFFENLKRFLQAQGIFDAGIYVLTICAPLNVLVSYTLVWNKYIGVGFIGAAIAVVLNFWLMFFLLLFYALYIDGRKCWGGFSRKAFTHWNDLGHLAFSGIIMLEAEELSYELLTLFSAYYGVSYLAAQSAVSTMAALLYMIPFAIGISTSTRIANFIGAKRTDFAHISSQVGLSFSFIAGFINCCILVFGRNLIANIYSKDPEVIKLIAQVLPLVGIVQNFDSLNAVAGSCLRGQGMQSLGSIVNLMAYYLFGIPLALILSWFFDMKLYGLWIGIGSAMLLIGLVEAYYVLFPDWDKIMTYAEILKETEDDEVDSDEYLTDSDDPDENTALLGA
What are the official names of this protein?
Uncharacterized transporter YDR338C.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RT25_HUMAN
Sequence: MPMKGRFPIRRTLQYLSQGNVVFKDSVKVMTVNYNTHGELGEGARKFVFFNIPQIQYKNPWVQIMMFKNMTPSPFLRFYLDSGEQVLVDVETKSNKEIMEHIRKILGKNEETLREEEEEKKQLSHPANFGPRKYCLRECICEVEGQVPCPSLVPLPKEMRGKYKAALKADAQD
What are the official names of this protein?
28S ribosomal protein S25, mitochondrial, MRP-S25, S25mt, Mitochondrial small ribosomal subunit protein mS25.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS25 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PSTB_TRIEI
Sequence: MLEHQTNTYQQNSTPALSAENLSIFYGDFKALKDISMRIPKNKVTAFIGPSGCGKSTLLRCFNRLNDLIDIFRLEGRILYHNQNIYDPDIDPVEIRRHIGMVFQKPNPFPKSIYDNIAYGVRVNGLAKSKEEMDEIVERSLRQAVLWDEVKDKLGQSGFALSGGQQQRLCIARAVAISPDVVLMDEPCASLDPISTVKVEELINELRQKYTIIIVTHNMQQATRIADLTAFFNAKAVESGQRFGYLVEFDKTNNIFQNPREKATQDYVSGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NHAP2_SHESH
Sequence: MSAETINNFFLIGALLIAVSVLLSAVSSRVGIPILLVFLGVGIMAGEDGPGGIHFDDYSVAYLVSNLALAVILLDGGMRTRVSSFRVALWPALSLATFGVAITTGLTGMMAAYLFDLNILQGLLVGAIVGSTDAAAVFSLLKGKRLNERVGATLEIESGSNDPMAVFLTVTLIAILASVGEGVSASFMVMSFIKQFGLGACLGLGGGWLLWQLINRIQLADGLYPVLVLSGGLIVFAISNSLGGSGILSIYLLGLLLGNRAMQGRHTILSVLDGMTWLSQIGMFLVLGLLLTPSDLTEVAIPALALAFGMILFARPISVWLSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLLVQGCSLGRAARLAKVELPTKPSPISRSGVAIYPKSDWELFVYHLSEHKWCVGEPIRRLNMPAGTHIAALYRGKDMLHPSGSTKLQTGDILCVLGHEKDLDALGTLFSEAPMQEELPRFFGDFFLDVDIQLASLAPIYGLELDDEAQYLSVGELLVKHLGDELVLGDQFEWQSLSWVVSELSQGEVVKVGIRLPNDS
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSD_SALRD
Sequence: MLTGGALWVDAWLWRGPMLTLAVGGLAFVLYFFRDPERTPPADALEAGIVAPADGRVVEIAEEDDPLYLEGPARRISIFLSPLDVHVNRVPARGVIEHAEYRPGDYLVAWHPKASEKNERSEFGLRHPTGTKLLFKQIAGAVARRIEYDLREGDTVETGARFGIVKFGSRMDLLVPPSVELHAKEGQVVRAGTTVLGRIPTPESGRSSSAEATAAPSASSARRSSAS
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DYLT5_HUMAN
Sequence: MMMSDNAKGRAAHSWKKRGSISSLSNHEFWRKEIHGRIKDSMSTVSYMEEPSQRDDISRLTVQMENTYQLGPPKHFPVVTVNHILKDVVTSYLQVEEYEPELCRQMTKTISEVIKAQVKDLMIPRYKLIVIVHIGQLNRQSILIGSRCLWDPKSDTFSSYVFRNSSLFALANVYAVYLE
What are the official names of this protein?
Dynein light chain Tctex-type 5, Tctex1 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain Tctex-type family.
Protein: STAP2_MOUSE
Sequence: MATALSPPRGPKLKGAPPSHYYESFLEKKGPCDQDYRKFWAGLQGLAICFYNSNRDLQPLEKLDLRLFSKLRDEALLGSSRDTAYHFSLVLRDQEVKFKVESLESCEMWKGFILTVVELRVPSNLTLLPGHLYMMAEVLTKEEVRRAAEVPWCFLQVSRLEAQLLLERYPECGNLLLRPGGDGKDSVSVTTRQILNGSPVVKHYKVKRAGSKYVIDVEDPFSCPSLEAVVNYFVTHTKRALVPFLLDEDYEKVLGFVDSDRENGESAWAVPSFRASGPALPANVLKPLPPVPVSVSSQEDKLPQLPPLPQLPDTDENYVTPIEDSPAAEYMNQDVSLSSQAVPLKPKKPARLPAKPPKPSVVPKPDLKAITSVWTRKLGGSSSQASSLVTRLGDITAELEEKLQKRRALEH
What is the function of this protein?
Substrate of protein kinase PTK6 (By similarity).  May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.
What are the official names of this protein?
Signal-transducing adaptor protein 2, STAP-2.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=The translocation to the membranes occurs in response to EGF when the protein is overexpressed in fibroblastic cells.
Protein: RL2_FRAT1
Sequence: MIEIKKAKPTSPGRRHVVSVKNTELHTGKPFKGLVEVKKSKAGRNNTGRITVRHQGGGHKQHYRIVDFKRNKDDITAKVERIEYDPNRSANIALVLYADGERRYIVAPKGLKKDMSVISGEKVDVAVGNCMPLRNIPLGTVIHNIEMKPKKGAQMIRSAGTFAQLVGKDNAYAIIRLRSGEMRRVLLDCRAVIGVVSNSEHNLKSLGKAGAKRWRGIRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVTPWGIPTKGYKTRRNKRSNKLIVQKRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RF1_CAMLR
Sequence: MLADKLKPFLTRFDELNTLLSDVNISNDISKMTALSKEQKNLEPIVEKAKEYLKTLDDIEENKLLLSDPELGELAKEELKNLELLKPNLEEELKILLLPKDPNDDKNIFLEIRAGTGGDEASLFVGDLVKAYIRYAENRDYKYEIVSSSEGSVGGFKEIIILIKGNGAYSRLKYEGGTHRVQRVPETESQGRVHTSAITVAIMPEVDDVEIQINPNDLKIDVMRSSGHGGQSVNTTDSAVRITHIPTGIVVVNQDGKSQHKNKESAMKVLKARLFEMQEQERLAKESEARKSQVGSGDRSERIRTYNFPQNRISDHRINLTLYRLDAILEGGLFDEIVEPLIAYYQAEALKQENL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAG_METTP
Sequence: MQSVDTTKYIIYADITADGIVERPDVVGAIFGQTEGLLGSDLDLRDLQKTGRLGRIDVQISSSGGKSMGTISIPSSFDKVETAILAAALETIDRVGPCMARIHVTKIEDVRAAKRKYIIDRAKRILVEMFDENLLETEQITEEIKQSVRVEEITYIGKDNLPAGPNVLDSDAILVVEGRADVLNLLKYGIKNAVAVGGTNIPPTITELCSKKIATAFTDGDRGGELIVKELLQVADIDYVARAPEGKCVEELTQKEIIRALRQKIPVEQVMDMYKIKPFTRKKREIVTKRKSLIRERPVSVRTVAQVVPIAHHAEIAPPHEIQTRVHQKEVHEHYEEPEIEGQEPEEWFKHHVEELDGTLTARLFDRNNNPIRDVAVRDLARELKESNGSVHGVIFDGVITQRLLDIAAEKGLDYLIGAKMGSIAKTPVGIKVITSGQ
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Also part of the exosome, which is a complex involved in RNA degradation.  Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: AROC_DESHY
Sequence: MRYLTAGESHGPKLVGILEGVPSGAKIDKETIDQALQERQKGPGRGGRMKIEKDQVTILSGVRGGLTTGAPIALEIINRDWANWEKIMAWGDEADLESRKVITPRPGHADLTGHLKYRTEVRNVLERASARETAMRVAIGNIAVQILEALGVEIRGQVLSVGKVHMNSEDTPEYWQRVQASEWKVGDPQGEEALYTQLQEARSKGESLGGVLQIQVQNLLPGLGSYVQWDRKLDGRLAQAVLSVQAIKGVAFGMGFAAGQHFGSEVHDPIGYDSGRGYYRYSNNAGGIEGGMTNGEPVIIEAVMKPIPTLYSPLSTVNLETKEVMEASVERSDVCAVPAALVVLKHVAAWEILQAILEKFPADTWDELDKAWHDYKRFVSER
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: NDBK_LYCMC
Sequence: MKFSLISVFLFAVFLSNENIFQAIADNRYLPTIFKNPVNAEQRSEAVMSSSLTNEEESRNWPHRATRNTLEKGQKRSPAARSEIEEMEEYDDRWMW
What are the official names of this protein?
Venom protein 3.1.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KREM1_MOUSE
Sequence: MAPPAARLALLSAAALTLAARPAPGPRSGPECFTANGADYRGTQSWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKHGEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMAAVVYSPDFPDTYATGRVCYWTIRVPGASRIHFNFTLFDIRDSADMVELLDGYTHRVLVRLSGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQATKEEPPQERPAVNQTLAEVITEQANLSVSAAHSSKVLYVITPSPSHPPQTAPGSHSWAPSVGANSHRVEGWTVYGLATLLILTVTAVVAKILLHVTFKSHRVPASGDLRDCRQPGASGDIWTIFYEPSTTISIFKKKLKGQSQQDDRNPLVSD
What is the function of this protein?
Receptor for Dickkopf proteins.  Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670).  In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity).  Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1 (PubMed:26206087).  Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822).  Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification (PubMed:27550540).
What are the official names of this protein?
Kremen protein 1, Dickkopf receptor, Kringle domain-containing transmembrane protein 1, Kringle-containing protein marking the eye and the nose.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: UPP_SHESH
Sequence: MKVVEVKHPLVRHKIGLMRAGDISTKRFRELAAEVGSLLTYEATADFATETVTIEGWNGPVEIEQIKGKKVTVVPILRAGLGMMDGVLENIPSARISVVGMYRDEETLEPVPYFEKLASDMPSRIALVVDPMLATGGSMISTIDLLKDRGCTEIKALVLVAAPEGVEALQKAHPDVELYTASIDRCLNEQGYILPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: IF3_CHLPN
Sequence: MALNFKINRQIRAPKVRLIGSAGEQLGILAIKDALDLAREAGLDLVEVASNSEPPVCKIMDYGKYRYGLTKKEKDSKKAQHQVRIKEVKLKPNIDENDFSTKLKQARTFVEKGNKVKITCMFRGRELAYPEHGFKVVQKMSQGLEDIGFVEAEPKLAGRSLICVVAPGTVKTKKKQEKSHAQDENQ
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENTR1_MOUSE
Sequence: MSGYARRQGAPPLSRTRSLVVPDAPAFYERRSCLPQLDCERPHGGDLHPHLFGFRPTFMCYVPSPVLASVGDTGFGYGKGKCTNQGPSGAPETRFGGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKEASRHPLGLEHSSPASQLMGYGLESQQPFFEDPTRASNLEEDEDDGWNITYLPSAVDQTHSSRDTQDSPPCDTYLSFFSNSSELACPESLPPWTLSDTDSRISPASPAGSPNADFAAHEESLGDRHLRTLQISYEALKDENSKLRRKLNEVQSFSETQTEMVRTLERKLEAKMIKEESDFHDLESVVQQVEQNLELMTKRAVKAENHVLKLKQEINLLQAQLSNLRRENEALRSGQGASLSVVKQNTDVALQNLHLVMNSAHASIKQLVSGADTLNLVAEILKSIDRISEVKDEVDS
What is the function of this protein?
Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis.  Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1.  Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1.  Plays a role in the formation of cilia.  Involved in cargo protein localization, such as PKD2, at primary cilia (By similarity).  Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (PubMed:16332174).
What are the official names of this protein?
Endosome-associated-trafficking regulator 1, Serologically defined colon cancer antigen 3.
What is the protein family that this protein belongs to?
Belongs to the ENTR1 family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome. Endosome. Recycling endosome. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes in a WASHC2- dependent manner with the retromer CSC complex at endosomes. During cytokinesis colocalized with PTPN13 at the midbody. Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia. Colocalizes with IFT88 and pericentrin at the centrosome.
Protein: MENE_STAAC
Sequence: MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRLTPNEMTNQMKSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNSLLDNTMGIQYETSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNVYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTSTGKLQRNKLYRG
What is the function of this protein?
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
What are the official names of this protein?
2-succinylbenzoate--CoA ligase, o-succinylbenzoyl-CoA synthetase, OSB-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
Protein: SYL_DESAP
Sequence: MEEKYVFAEIEEKLRRRWETEGIYHVPDFSNRPKYYCLEMFPYPSGNLHMGHVRNYAIGDVVARFKTMRGYDVLHPMGWDAFGLPAENAAIQHGVPPARWTWDNINVMRTQLKLLGVSYDWRRELATCHPGYYRWTQWLFLQFYHRGLAYKAKAPVNWCPSCATVLANEQVVAGGCERCKTAVERRELEQWFFRITAYADRLLKDLAKLPGWPEKVKVMQENWIGRSTGAEIAFPLAGTDEAIRVFTTRPDTLGGVTYMTIAPEHPLVSRVTTPEHRAAVEAFTERARSLSELDRTAGEHEKEGLFTGAYCVNPLTGEQVPVFVANYVLMEYGTGCVMGVPAHDQRDFEFARKYGLPVRVVIQPEGDLLDGDTMSQAYTGPGRLVNTPGFDRMANAEAIPAITRYLEARGAARFQVQYRLRDWLISRQRYWGAPIPIVYCEGCGVVPVPEEGLPVLLPEDVAFKPTGRSPLTESPDFVNTTCPTCGGPARRETDTMDTFMCSSWYYFRFTSPREENGPWGLERVDRWLPVDQYIGGVEHAILHLMYSRFFTKVLYDMGLVKVQEPFTNLLTQGMVLKDGAKMSKSKGNVVSPEDILNRYGADTTRLFVLFAAPPERDLEWSDQGVEGCYRFLQRVWRLVNSVADEIRGAAPVPSANLVGVNRSMRRLTHQTIKKVTEDIETRFNFNTAISAAMELVNGMYHFRDRVAPVNRDPAVMREAVERLLLLLAPFAPFLADELWARTGHPESIHREPWPEYDPELLVEDQVEIVVQINGRVRDRLMVAADIAPEAMRDTVLEQPRVQALVAGKEIVKVVPVPGKLVNIVVR
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAFB_ECOLX
Sequence: MNSASTHKNTDFWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLLVFFAPFFLYVFAPLLHLNIWAGALTGGVFIGFVFSAGAGAIEAYIERVSRSSGFEYGKARMFGCLGWALCATMAGILFNVDPSLVFWMGSGGALLLLLLLYLARPSTSQTAMVMNALGANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFDQQFAIFFRSFFDTPQAGIKAFGFATTAGEICNAIIMFCTPWIINRIGAKNTLLVAGGIMTIRITGSAFATTMTEVVILKMLHALEVPFLLVGAFKYITGVFDTRLSATVYLIGFQFSKQLAAILLSTFAGHLYDRMGFQNTYFVLGMIVLTVTVISAFTLSSSPGIVHPSVEKAPVAHSEIN
What is the function of this protein?
Responsible for transport of raffinose into the cell (PubMed:2556373, PubMed:18008022).  Can also transport lactose and melibiose (PubMed:2556373).  Has weak activity with maltose (PubMed:18008022).
What are the official names of this protein?
Raffinose permease, Raf permease.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Oligosaccharide:H(+) symporter (OHS) (TC 2.A.1.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MDTK_ECO45
Sequence: MQKYISEARLLLALAIPVILAQIAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSVLIMLVLWNAGYIIRSMQNIDPALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATAAVYWVMFLAMVSYIKRARSMRDIRNEKGTAKPDPAVMKRLIQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVGYRLGQGSTLDAQTAARTGLMVGVCMATLTAIFTVSLREQIALLYNDNPEVVTLAAHLMLLAAVYQISDSIQVIGSGILRGYKDTRSIFYITFTAYWVLGLPSGYILALTDLVVEPMGPAGFWIGFIIGLTSAAIMMMLRMRFLQRLPSAIILQRAAR
What is the function of this protein?
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
What are the official names of this protein?
Multidrug resistance protein MdtK, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.