PharMolix/UniProtQA huggingface dataset:
Protein: DORT_PARTR
Sequence: ADVPGNYPLDKDGNTYTCLKLGENKDCQKVCKLHGVQYGYCYAFECWCKEYLDDKDSV
What is the function of this protein?
Binds to sodium channels (Nav) and affects the channel activation process (By similarity).  In mice, causes hyperactivity that persists until death.
What are the official names of this protein?
Dortoxin, Dorsotoxin.
What is the protein family that this protein belongs to?
Belongs to the long (3 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RK2X_CYACA
Sequence: STKNGRDSNPKYLGVKTCHAQFVTAGSILVRQRGSKFHHGQNVGVAK
What are the official names of this protein?
50S ribosomal protein L27, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PLYL_EMENI
Sequence: MMGKSVWVFAALFPAVLAADIYVSPDGSDDAAGTIDAPLQSIQLAVDQATAGSTIYLRGGTYTPTSNIQITKSGTASAPYVLRAYEGESVIIDGEELPGTPADLDASLDNADRGILHIQDAEYWEFYDLELINGPYGVYARDASNNHYERITTRNNYETGFQLQGESSNNVVLYLDSYGNRDPRKNGESADGFACKEGSGEGNILRGARLWNNVDDGLDLWYAVNPVHPRISANTSREFKSAVTIEDTIAWGNGFNRWDFTPFEGDGNGFKLGGGDDTDIGPADHIITNCIAFSNAKDGFTDNSQPGNFVLTRNTAWDNTAVGFKFGTAVATLTGNIAASNGEAPTSLSDEQISDGNSWDGDEDWDDGSFVSVDVSLVQGERNADGTIEPSGFLLPADGEEIGATTDWSA
What is the function of this protein?
Presents an endo-cleaving activity on the homogalacturonan (HG) region in pectin (PubMed:35802235).  Active on homogalacturonan with a degree of polymerization above 4, and does not appear to be affected by the degree of methylation of the substrate (PubMed:35802235).  Does not degrade linear rhamnogalacturonan (PubMed:35802235).
What are the official names of this protein?
Pectate lyase PEL9, AnPL9.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 9 family.
Protein: ISPF_ACIC1
Sequence: MTAALLPRVGIGVDVHPFSPDRPLWLAGLHWPGEPGLAGHSDADVVIHALCNALLSAAGLGDLGTQFGTAEPEWRDAAGTRLLTETVRLVRDAGYAVGNAAVQLLGERPKLRERRTEAEQLLTETVGAPIALSAATTDGLGFLGRRDGLAAVATALVFPAR
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: HIS8_ECOUT
Sequence: MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFQLTQQTLNRYPECQPKVVIENYAQYAGVKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPTLDNWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAIVVADEAYIEFCPQASLAGWLAEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVAQIITEREYLIAALKEIPCVEQVFDSETNYILARFKASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQCVIDALRAEQV
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: Y5813_ARATH
Sequence: METFSLKDCSSVASSPISSPNISTLLKIKVLSWSKETGLPASVHVRVCNKSFNLHKSLLCAKSGYFKEREDQLSEIEIPQEFPGGAETFEKIMLFIYGCPTLIHPFNIAGLRCAAQFLEMTEQHSTGNLCERFDLYLNQVVLQNWDDTLVVLKKCQDLVPWSEDLLIVSRCIESLAFTACMEILDPERRREKPVIMLEGMVNQPWEYTNIERIINQDTWIKDLTDLPFEFFKKIIGSLRRQGMKERYVSPLVALYASKSVIPEGQTNTDILQRALDLLLTRDKAYRFVPVGFYFACLAHNLKHDTVLKLQDQIVSLLHTAQPENFIYPKAGNRQVAFSQELLTMESLFSVYVSTESERHLTSSSSNVRVGKLWDIFLSRLPYDQEMKTTRFIELIETVPMSFRESHDQLYLAVNAFLQVHTNISQEEKGSICSYLNCQKLSQEASLELVKNEKMPLRLVVQALFIQQLNTHQAFKDCSDSFRFTNSADFSGSVVPSSRPLTSQQSPCTDDETGPRNRPLCFLMQKDATLDEFESTSFRIHNLEEQLVSLKKSLHSHDNLKKPNCLGKRSASRNKNTFGQVTTACIGSVSFTSQRKYANRLLQILRRVNLFGSRKTNRSKAGESER
What is the function of this protein?
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
BTB/POZ domain-containing protein At5g48130.
What is the protein family that this protein belongs to?
Belongs to the NPH3 family.
Protein: RS19_XYLFT
Sequence: MPRSTKKGPFFDHHLIKKVESAAGSKRPIKTCSRRSVILPQMVGHTIAIHNGKNYHPVVINENMVGHKLGEFSITRVFKGHCGDKKSGK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: YECA_SHIFL
Sequence: MKTGPLNESELEWLDDILTKYNTDHAILDVAELDGLLTAVLSSPQEIEPEQWLVAVWGGADYVPRWASEKEMTRFMNLAFQHMADTAERLNEFPEQFEPLFGLREVDGSELTIVEEWCFGYMRGVALSDWSTLPDSLKPALEAIALHGTEENFERVEKMSPEAFEESVDAIRLAALDLHAYWMAHPQEKAVQQPIKAEEKPGRNDPCPCGSGKKFKQCCLH
What are the official names of this protein?
Uncharacterized protein YecA.
Protein: RS16_COXBN
Sequence: MVVIRLARGGSKKNPFYHIVVADRRKPRDGRFIERVGYYNPMARGQDIRLQLEKERISHWLNQGAQTSLRVKHLIKKLEKSPEEAQKGGMRKGEFKRLQAEQAAKAQKKAVATEEPKAEEAKEAPPAESQAAEGKEE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: ENASE_CHICK
Sequence: MQSQSVMLELREQDEVWVRLYKGERENAVFSDEYDTYITFSGHLINFQPAAEPLGTTVLHAAVDTRPQPARYFDTGTTEPVSFFLSGLEELLAWHPSSDDEFNVCAVPLAQRQPPLHSRRPRTLLCHDMRGGYLEDRFIQGSATRNPYVFYHWRYVDIFVYFSHHTVTIPPVCWTNAAHRNGVPVLGTFITEWADGEKLCEAFLAGGEDAYRAVSHQLARIAQHYRFDGWLINIENALSAAAVGNLSPFLRHLTAEVHGAVPGGLVIWYDSILESGTLRWQNELNQQNRVFFDACDGLFVNYNWKEEHLERTRELAGQRHADVYIGVDVFARGDVVGGGFDTNKSLSLIRKHGLSAAIFAPGWVYKHLGEENFLLNEDKFWGLLEDYLPTHSICTLPLATSFSVGMGTGMFLAGKEEEAGPWYNLSAQEIQPLYPERRGWLSTSCCLQDAWCGGSSLRVQGTIPPGEERVAIRLSLWVDLGSSGFSLSICGTLASGPHRDDFTVALELTTWHSSRCHDGTVTVLPSEDEPHGRHHPHLLPAPPPALSRMLAACSHGAQGWTSRCYEQELRGCSLRDLSLLVSRQQASPQETSFSCLLGELRVLDAGSMAASPPQVQSLTASQLWWQDGPSAEQLSLSLTLRWAFPPGRAACFRVLSQGARCHRAQPAQPQLLGLAHGCQYRAVGLAVPRPAPGQSCQLELLVEPVLPSELPVGPERWGRLLLVYSEPA
What is the function of this protein?
Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core.  Involved in the processing of free oligosaccharides in the cytosol.
What are the official names of this protein?
Cytosolic endo-beta-N-acetylglucosaminidase, ENGase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 85 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: COAX_CHLTE
Sequence: MQSSRGARAADVPVRLVVDIGNTSTTLAIFTGDEEPSVESVPSALFADSSTMREVFGNMARKHGEPQAIAICSVVPSATAVGSALLESLFSVPVLTICCKLRFPFRLDYATPHTFGADRLALCAWSRHLFSEKPVIAVDIGTAITFDVLDTVGNYRGGLIMPGIDMMAGALHSRTAQLPQVRIDRPESLLGRSTTECIKSGVFWGVVKQIGGLVDAIRGDLVRDFGESTVEVIVTGGNSRIIVPEIGPVSVIDELAVLRGSDLLLRMNMP
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMWC_DESVH
Sequence: MRNGRTLLRWAGVLAATAIIGVGGFWSQGTTKALPEGPGEKRADLIEIGAMERFGKLDLPKVAFRHDQHTTAVTGMGKDCAACHKSKDGKMSLKFMRLDDNSAAELKEIYHANCIGCHTDLAKAGKKTGPQDGECRSCHNPKPSAASSWKEIGFDKSLHYRHVASKAIKPVGDPQKNCGACHHVYDEASKKLVWGKNKEDSCRACHGEKPVDKRPALDTAAHTACISCHMDVAKTKAETGPVNCAGCHAPEAQAKFKVVREVPRLDRGQPDAALILPVPGKDAPREMKGTMKPVAFDHKAHEAKANDCRTCHHVRIDTCTACHTVNGTADSKFVQLEKAMHQPDSMRSCVGCHNTRVQQPTCAGCHGFIKPTKSDAQCGVCHVAAPGFDAKQVEAGALLNLKAEQRSQVAASMLSARPQPKGTFDLNDIPEKVVIGSIAKEYQPSEFPHRKIVKTLIAGIGEDKLAATFHIEKGTLCQGCHHNSPASLTPPKCASCHGKPFDADRGDRPGLKAAYHQQCMGCHDRMKIEKPANTACVDCHKERAK
What is the function of this protein?
HMWC (high-molecular-weight cytochrome c), ORF2, ORF3, ORF4, ORF5 and ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates.
What are the official names of this protein?
High-molecular-weight cytochrome c, Cytochrome CC3.
What are the subcellular locations of this protein?
Periplasm.
Protein: TRI41_HUMAN
Sequence: MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRSSWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP
What is the function of this protein?
E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016).  Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:29899090, PubMed:31979016, PubMed:28169297).  Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876).  Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity).  Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM41, RING finger-interacting protein with C kinase, RINCK, Tripartite motif-containing protein 41.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RPIA_STRPG
Sequence: MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQAEGLGIPLKSIDDIDSIDLTVDGADEVDKDFNGIKGGGAALLMEKIVATPTKEYIWVVDASKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMKGDSRLVTDMQNYIIDLDLGCIKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPKAG
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: CYMEJ_MELDN
Sequence: GSIPCGESCVYIPCISSIVGCACKSKVCYKN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide mden-J.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: ADEC_SULNB
Sequence: MEMKSNYVDIFKREIFPAKVRVEKGKIASIERIDTPCDTYILPGFVDAHIHIESSMLPPSEFARLAVCHGTVATVSDPHEIANVLGIPGVGYMLDNSEMTPFKFYFGASPCVPATTFETSGATLGPDEIESLLKMPQIKYLSEVMNFPGVINGDPDMLAKIAKAKALHKRIDGHAPGLRGDELTKYIEAGIETDHEAFTYEEGLEKLQKGMKILIREGSAAKNFEALAPLIPAYPNKLMFCSDDRHPNDLAREHIDGHVRRAIAKGYDLFDVLRIASVNPVEHYGLEVGLLRVGDPADFIVVEDLKDFKVLQTVIDGEIVARGKKPLIDSVTVETPNHFHTGIKKEEDFILERCVHTEIIHALDHSLITEEEIMDLSSGKAKDVLKITVVNRYEDVKPAVAYVHGFGLKKGAIASSVAHDSHNIIAVGCSDALIAKAVNTIIGNRGGICAVTEEEIEVLSLPIAGLMSDKDGFEVANRYADLDRMVREYFTSLLSAPFMTLSFMALLVIPELKLSDKGLFDGRSFHFIDSCRR
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: UD16_RAT
Sequence: MACLLPAARLPAGFLFLVLWGSVLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIVVLVPEVNLLLGESKYYRRKSFPVPYNLEELRTRYRSFGNNHFAASSPLMAPLREYRNNMIVIDMCFFSCQSLLKDSATLSFLRENQFDALFTDPAMPCGVILAEYLKLPSIYLFRGFPCSLEHIGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIANILENYLYHCLYSKYEILASDLLKRDVSLPALHQNSLWLLRYDFVFEYPRPVMPNMIFIGGTNCKKKGNLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTLLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH
What is the function of this protein?
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
What are the official names of this protein?
UDP-glucuronosyltransferase 1-6, UDPGT 1-6, UGT1*6, UGT1-06, UGT1.6, A1, P-nitrophenol-specific UDPGT, UDP-glucuronosyltransferase 1A6, UGT1A6.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: FIBA_HYLLA
Sequence: ADTGEGEFLAEGGGVR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: G37L1_MOUSE
Sequence: MRWLWPLAVSLVVVLTVGLSGVSGAATSSLGGHRAKVQEQQSRPRRGTKDEGPKEVQHYVPEEWAEYPKPIHPAGLQPTKTLEATSPNPDKDGATPGNGQELRVNLTGTPSQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMMLAVPELLLWQLAQEPAPTAGTVDSCIMKPSADLPESVYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKPECRAGRHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASDSSATVSADSKLKAEVSSSIYFHKPRESPPLLPLGTPC
What is the function of this protein?
G-protein coupled receptor (PubMed:27072655).  Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity).  However, other studies have shown that prosaposin does not increase activity (By similarity).  It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity).  Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (PubMed:24062445).  Regulates baseline blood pressure in females and protects against cardiovascular stress in males (PubMed:29625592).  Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (PubMed:28795439).
What are the official names of this protein?
G-protein coupled receptor 37-like 1, Endothelin B receptor-like protein 2, ETBR-LP-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Note=Associates with the basal membrane of Bergmann glia cell primary cilia.
Protein: OX2G_RAT
Sequence: MGSPVFRRPFCHLSTYSLLWAIAAVALSTAQVEVVTQDERKLLHTTASLRCSLKTTQEPLIVTWQKKKAVGPENMVTYSKAHGVVIQPTYKDRINITELGLLNTSITFWNTTLDDEGCYMCLFNMFGSGKVSGTACLTLYVQPIVHLHYNYFEDHLNITCSATARPAPAISWKGTGSGIENSTESHSHSNGTTSVTSILRVKDPKTQVGKEVICQVLYLGNVIDYKQSLDKGFWFSVPLLLSIVSLVILLVLISILLYWKRHRNQERGESSQGMQRMK
What is the function of this protein?
Costimulates T-cell proliferation.  May regulate myeloid cell activity in a variety of tissues.
What are the official names of this protein?
OX-2 membrane glycoprotein, MRC OX-2 antigen.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GCST_PYRHO
Sequence: MVKRVHIFDWHKEHARKIEEFAGWEMPIWYSSIKEEHLAVRNAVGIFDVSHMGEIVFRGKDALKFLQYVTTNDISKPPAISGTYTLVLNERGAIKDETLVFNMGNNEYLMICDSDAFEKLYAWFTYLKRTIEQFTKLDLEIELKTYDIAMFAVQGPKARDLAKDLFGIDINEMWWFQARWVELDGIKMLLSRSGYTGENGFEVYIEDANPYHPDESKRGEPEKALHVWERILEEGKKYGIKPCGLGARDTLRLEAGYTLYGNETKELQLLSTDIDEVTPLQANLEFAIYWDKDFIGKDALLKQKERGVGRKLVHFKMIDKGIPREGYKVYANGEMIGEVTSGTLSPLLNVGIGIAFVKEEYAKPGIEIEVEIRGQRKKAVTVTPPFYDPKKYGLFRET
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Probable aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: TAL_SHEPA
Sequence: MANTLEQLKAFTTIVADTGDIEAIKRYQPEDATTNPSLILKASEIPEYSALIENAIDWAKSQSDVLAQQIEDAGDKLAVNIGLEILKIVPGRISTEVDARLSFDKEGSIAKAHKLIKLYQEAGIDKSRILIKLASTWEGICAAKQLEQEGINCNLTLLFSFAQARACAEAGVYLISPFVGRILDWYKKDTGLEYSATDDPGVVSVTSIYDYYKRHGFNTVVMGASFRNTGEIIELAGCDRLTIGPALLEELQNSTTPIVQKLLPATEVVAPEAEMTEAQFRWEFNEDPMAVEKLAEGIRNFAIDQGKLEVMLKEKLSS
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCP_CLOBK
Sequence: MSMFCYQCQEAAGGRGCTVKGVCGKTEDIAKTQDLIIYVVKGIAIYSSQVREIGLNTSEADKFIVESLFSTITNANFDAKALNARVQEGLKIRQSLKDAIIKAGGSYNSKENKSWTSKFLSVLGIKNDKDEKEIHDAAVWAANNPEDFKKKAETVGVLATENEDIRSLRELLTYGLKGMAAYLEHANNLGYDEDSIHAFMEKALVATLDDTLSADELTALVLECGKYGVDVMALLDKANTSTYGNPEITKVNIGVRNNPGILISGHDLKDMEELLKQTEGTGVDVYTHSEMLPANYYPAFKKYKHFVGNYGNAWWKQNEEFEAFNGPILMTTNCIVTPKASYKDRMYTTGVTGFEGVKHINASKDGKKDFSEIIEHAKRCSSPKEIEKGEIIGGFAHNQVLALAPQVVDAVKTGAIKRFFVMAGCDGRMKSRNYYTDFAKALPKDTVILTAGCAKYKYNKLDLGDINGIPRVLDAGQCNDSYSLAVIALKLKEVFELEDINELPISYNIAWYEQKAVIVLLALLHLGVKNIHLGPTLPAFLSPNVAKILVENFGIGTISSVDEDIKMFMN
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OX26_RAT
Sequence: MRCLCSWLCLLLPLSACFPLLDRRGPTDIGDIGARMSWVQLTEGHTPRSVQSPRPQALLVVAKEQQASRREHTGFRLGRQDSGSEATGFLPTDSEKASGPLGTLAEELSSYSRRKGGFSFRFGR
What is the function of this protein?
Stimulates feeding and grooming behavior, metabolic rate and locomotor activity and increases blood pressure.  May have orexigenic activity.  May promote aldosterone secretion by the adrenal gland.
What are the official names of this protein?
Orexigenic neuropeptide QRFP, P518.
What is the protein family that this protein belongs to?
Belongs to the RFamide neuropeptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: DIAP2_DROME
Sequence: MTELGMELESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPICSMVLAPNHCGNVPRSQESDNEGNSVVDSPESCSCPDLLLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNLDELGIQPTTLPLRPKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASSQPATAPAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS
What is the function of this protein?
Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria (PubMed:16894030, PubMed:17068333).  Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides (PubMed:17068333, PubMed:24374974).  Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides (PubMed:22549468).  Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice (PubMed:18166655).  Suppresses rpr and hid-dependent cell death in the eye (PubMed:8548811).  However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway (PubMed:17068333).  Plays a role in regulating the expression of ion channels (PubMed:24374974).
What are the official names of this protein?
Death-associated inhibitor of apoptosis 2, Apoptosis 2 inhibitor, IAP homolog A, IAP-like protein, ILP, dILP, Inhibitor of apoptosis 2.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CULP5_MYCTU
Sequence: MPGRFREDFIDALRSKIGEKSMGVYGVDYPATTDFPTAMAGIYDAGTHVEQTAANCPQSKLVLGGFSQGAAVMGFVTAAAIPDGAPLDAPRPMPPEVADHVAAVTLFGMPSVAFMHSIGAPPIVIGPLYAEKTIQLCAPGDPVCSSGGNWAAHNGYADDGMVEQAAVFAAGRLG
What is the function of this protein?
Does not exhibit cutinase activity.
What are the official names of this protein?
Probable carboxylesterase Culp5, Cutinase-like protein 5, Culp5.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
Protein: DNCH_PROM2
Sequence: MKPADWLILQRKVRFGDCDSAGVIHFHNLLKWSHEAWEESIEIYGIPYKDIFPDFSIRKSQIVFPIVNCEANFLAPIKIGDFLKVKIAPHKINTHLFQVNSFFIKNGNKVAEGKIIHCSLDIDSRNKIELPDQLERWIEASNVSTNLKEC
What is the function of this protein?
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA hydrolase, DHNA-CoA hydrolase, DHNA-CoA thioesterase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
Protein: K1C27_MOUSE
Sequence: MSVRFSSASRRLGSVRLSSAGAALGAGNACGVPGIGSGFSCAFGGSSLAGGLGMGGASCGAFTANEHGLLSGNEKVTMQNLNDRLASYLENVQALEEANADLEQKIKDWYEKFGPGSCRGLDHDYSRYFPIIDDLRTQIISATAHNANIILQNDNARLTADDFRMKYENELALHQSVDADINGLRRVLDELTLCRTDLEVQLETLSEELAYLKKNHEEEMQALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSASLQQQISDDAGATTSARNELTEMKRTLQTLEIELQSLLAMKHSLECSLTETEGNYCTQLAQIQAQISALEEQLHQVRTETEGQKLEYEQLLNVKAHLEKEIETYCRLIDGDEGSCVKAKGQGRPGNQTKDSPKTAIVKTVVEELDPRGKVLSSRVHTLEEKSTKVNKTEQRIPS
What is the function of this protein?
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).
What are the official names of this protein?
Keratin, type I cytoskeletal 27, Cytokeratin-27, CK-27, Keratin complex-1, acidic, gene C29, Keratin-27, K27, Type I inner root sheath-specific keratin-K25irs3.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.