PharMolix/UniProtQA huggingface dataset:
Protein: GRC3_YARLI
Sequence: MTKRKSALSALKPTKKQVISSEDSDPEVVVVTNPPLDSPDAEESFISITEEDEAVRQLSTFDFSAKNTKVVRDETRGRSRVFHGMKFKETIVLRGAYVVTVWSGVIHINGALVNINSPVDIPVFAPASHALPQIEAAAGAPETRESGDEDVMEALHQLEGSSVIVEIAAMPRRSENPLITVSNFGKMSSGNIVPFVRQLWHCSEDDGSNYSRIYNTASVVTKSQAAVIPGIYDEWAEVCDDIRRLKHSSTMVVGSQNTGKSTFCKYLSAFMTTKKTGTSVAFVDLDPSNCEFTAPGQVSVTVIGAGHLSPYSILGPSFTHVTAPTYSRFVGYNNPKDDTRGYIEACKAVIDFAKGLKLPLVFNTCGWVRAAGHDLLRQLIDHVKPSDVVFTRDPGVDADQARLAESVKARSHVLDAPDAEPPRFTGAEQHSLQTVTYLHGGNLASHLSDLPALEVGLESVYVGILDSEGVDLADVALSTNSTLLAVMTMDKKTVKHAEITPDGLQYLPNFDIPQGECLGQAMVQFAGASVRLHTPVSASLLNAQLAADKAIVLVRGRIPLPVYELWDSRKGGEQAYVSFDVNSGVGSEAWVARRGLKRK
What is the function of this protein?
Polynucleotide 5'-kinase involved in rRNA processing.
What are the official names of this protein?
Polynucleotide 5'-hydroxyl-kinase GRC3.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. NOL9/GRC3 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ZNUC_PSESM
Sequence: MAEALIRLEQVAVTLSGQSVLDNIQLSVRPGEIVTLIGPNGAGKTTLVRAVLGLLKPDSGTVWRKPKLRVGYMPQKLHVDQTLPLSVLRFLRLVPGVDRVAAQSALEEVGAEKVIDSPLQGISGGEMQRVLLARALLRKPELLVLDEPVQGVDVAGQAELYSLITRLRDRHQCGVLMVSHDLHLVMSTTDQVVCLNRHVCCSGHPEQVSHDPAFVELFGKNAQSLAIYHHHHDHAHDLHGAVVNDAPTASPPHTHVHGDSCKHG
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TSAE_MYCBO
Sequence: MSREGIRRRPKARAGLTGGGTATLPRVEDTLTLGSRLGEQLCAGDVVVLSGPLGAGKTVLAKGIAMAMDVEGPITSPTFVLARMHRPRRPGTPAMVHVDVYRLLDHNSADLLSELDSLDLDTDLEDAVVVVEWGEGLAERLSQRHLDVRLERVSHSDTRIATWSWGRS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB.  TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).
What are the official names of this protein?
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE.
What is the protein family that this protein belongs to?
Belongs to the TsaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_BURMS
Sequence: MTEPTQPQAAVAADENQIVAERRDKLRALRDQGIAYPNDFQPTHHAAGLQTEYADADKEALDAKALDVAVAGRMMLKRVMGKASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDIVAARGVLFRTNKGELSVKCTELRLLAKALRPLPDKFHGLADQETRYRQRYVDLIVTPETRATFRARTKAIASIRKFMSDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQAAVDALGTATIRYQGRELDLAKPFHRLTITQAIQKYAPNYTDGQLSDDAFLRGELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEVSPLARESDTVAGITERFELFVTGREIANGFSELNDPEDQAARFRKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPTIRDVLLFPHLRRED
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAL1_SALG2
Sequence: MNLKEKTRALFAEIFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRTVRVIAADYDNQVDEFSLDAPIVTHDSQQWSNYVRGVVKHLQQRNNAFGGVDMVISGNVPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRTLGAKAVSMPKGVAVVIINSNFKRTLVGSEYNTHREQCETGARFFQQPALRDVSLEAFNAVASELDPVVAKRVRHVLSENARTVEAASALEKGDLQRMGQLMAESHASMRDDFEITVPQIDTLVDIVKATIGDQGGVRMTGGGFGGCVVALIPEDLVPAVQQAVAQQYEAKTGIKETFYVCKPSQGAGQC
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSA_PSYCK
Sequence: MTQKSFPIAPEFLAAANITAEQYAEQYKQSIASPEATDAFWAERAELIDWIKKPTKISDVSYDLEDFRIKWFEDGELNISVNCLDRHVRNNPYKPAIIWEGDHPSLHKIISFKELHEAVCRLGNAMRKLGVKKGDRVTLYMPMIPEAMVAMLACTRIGAVHSVVFGGFSAESLGNRIIDSQSKLVITADEGIRGNKRTPLKANVDRALDMDGTDSVSNVIVVHRTGNSVPMSGRRDIWYHSLVDGESQHCEPEVMNAEDPLFLLYTSGSTGKPKGVLHTTGGYITYALSTFRDVFDIKEDDVYWCTADVGWVTGHTYATYAPLANGTTTVMFEGVPEYPTWARIGHIIDKHQITVLYTAPTAIRAMMKEGDTFVRESDRSSLRLLGTVGEPINPEAWDWYYHVVGGSKCPVVDTWWQTETGGIMLAPIPGTVAMKPGAAMNPLYGIVPEVIDTDGVALEGAAEGNLVINSSWPGQMRTIYQDHARFLTTYFTEYPGYYFTGDGVQRDEDGHYWITGRVDDVLNVSGHRLGTAEIESSIVAHPATAEAAVVGMPHDIRGMGICAFVILKSSETATESLKSELNRHVRSEIGPIANLDAIYMVNVLPKTRSGKIMRRILRSLAAGQYVGLGDLSTLADSSVINELVEVVKTERAKSH
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: DEOB_CLOP1
Sequence: MSKYKRIFTIVIDSLGIGAMNDSEKYGDVNVDTLGHIAESVDTFNIPNLQKMGIANLHPIKHVAPVENPIGYQAKMAEASVGKDTMTGHWEMMGLHITKPFKTFTDTGFPQELLDELTARTGHKIVGNKSASGTEILDELGEHQIATGDMIVYTSADSVLQICGQEETFGLEELYRCCEIARELTLKDEWKVGRIIARPYLGTKKGEFKRTSNRHDYALKPYGRTVLNELKDNNFDVISVGKIKDIFDGEGITEGNKSKSSVHGMEQTLEIMDRDFTGFCFVNLVDFDALWGHRRNPQGYAEELEKFDVNLGKVLEKLHEDDLLIITADHGNDPTYTGTDHTREYVPFLAYSPSMKGHGQLETPKTFATIGATIADNFGLKMPEGTIGESVLNKLV
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCHR1_PANTR
Sequence: MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
What is the function of this protein?
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
What are the official names of this protein?
Melanin-concentrating hormone receptor 1, MCH receptor 1, MCH-R1, MCHR-1, G-protein coupled receptor 24, MCH-1R, MCH1R, MCHR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FPOK_METMA
Sequence: MTAIPLTFYLGLAALLFSIGLYGVMTHKSGIRLIMCIELMLNSANLNLVAFSSYTDTLHGQVFAMFSIALAAAEAAVGFAIFMAIYRMHDKINLDELNILRW
What is the function of this protein?
Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system.  The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines.  Catalyzes the oxidation of methanophenazine to dihydromethanophenazine.  It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane).  It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  It also catalyzes the oxidation of F(420)H(2) with quinones such as 2,3-dimethyl-1,4-naphthoquinone, 2-methyl-1,4-naphthoquinone and tetramethyl-p-benzoquinone.
What are the official names of this protein?
F(420)H(2) dehydrogenase subunit K, F(420)H(2)-dependent phenazine dehydrogenase subunit K, F(420)H(2)-dependent phenazine oxidoreductase subunit K, FPO subunit J, Methanophenazine hydrogenase subunit K, Methanosarcina-phenazine hydrogenase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GREA_AGRVS
Sequence: MVDKVPMTQNGFSKLQEELRWRQQEERPRIIEAIAEARAHGDLSENAEYHAAKEAQSHNEGRVSELEDLTARAEVIDLSKMSGSKIKFGATVKLIDEDTDEEKIYQIVGDQEADVKAGRISISSPIARAMIGKEAGDSIEVVAPGGSKAYEIIAVNWG
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: BR2F_PELLE
Sequence: MFTMKKSLLLIFFLGTISLSLCQEERNADDDDGEMTEEEKRGIMDTLKNLAKTAGKGALQSLVKMASCKLSGQC
What is the function of this protein?
Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
What are the official names of this protein?
Brevinin-2Ef.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: PADGT_ACHLA
Sequence: MKVLLYSQKQSMLKKSGIGRAFYHQKRALEAVGIEYTTDPKDTYDLVHVNIAHSNKIKKFRKKYPVIVHGHSTVQDFRRSFAFWRVIAPFFYKHLQNIYGIADLIITPTRYSKFLIESMHVVKSPVVALSNGIDLDAYEYKQENVDAFRKHFDLEPNQKVVIGVGLLFERKGIHDFIEVARTMPNVTFIWFGNLSKLATTHFIRKRIKNKPKNMIMPGYVDGAVIKGAFSGADCVFFPSYEETEGIVVLEGLASKTPVVLRDIPVYYDWLFHKEHVLKGHNNFEFSKLIEKVLHEDQTEMIENGYKIVQDRSIEKIGEGLKQAYQEVIKIKR
What is the function of this protein?
Processive glucosyltransferase involved in the biosynthesis of both the non-bilayer-prone alpha-monoglucosyldiacylglycerol and the bilayer-forming membrane lipid alpha-diglucosyldiacylglycerol.  These are major components for maintaining the anionic lipid surface charge density, for balancing the bilayer to non-bilayer phase equilibria and for keeping a constant lipid bilayer spontaneous curvature (curvature packing stress).  Catalyzes the transfer of a glucosyl residue from UDP-Glc to diacylglycerol (DAG) acceptor to form the corresponding alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol), which then acts as acceptor to give alpha-diglucosyl-DAG product (3-O-(alpha-D-glucopyranosyl-alpha-(1->2)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol).  It can only use UDP-Glc as sugar donor.
What are the official names of this protein?
Processive diacylglycerol alpha-glucosyltransferase, Alpha-diglucosyldiacylglycerol synthase, Alpha-DGS, DGlcDAG synthase, Alpha-monoglucosyldiacylglycerol synthase, Alpha-MGS, MGlcDAG synthase, Glucosyl-alpha-1,2-glucosyldiacylglycerol synthase, UDP-glucose:1,2-diacylglycerol 3-alpha-D-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
What are the subcellular locations of this protein?
Cell membrane.
Protein: KITH_SWPVK
Sequence: MSCGFIHLILGPMFSGKSTELIRLVNRYQIATYNCRVIKYSKDNRYGNDAVYTHDKCYISAVSTDSLFDIKDTLDDVDIVGIDEGQFFNDIVEFCEYIANKGKIVIVAALDGTYERKPFGNILNLIPLSEKVTKLNAICMICHRDASFSKRLSDEKEIELIGGKEKYLSVCRSCYLT
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
Protein: DEF2_RAPSA
Sequence: MAKFASIIVLLFVALVVFAAFEEPTMVEAQKLCQRPSGTWSGVCGNNNACKNQCIRLEKARHGSCNYVFPAHKCICYFPC
What is the function of this protein?
Possesses antifungal activity sensitive to inorganic cations.  Induces potential changes in fungal membranes and increased K(+) efflux and Ca(2+) uptake.
What are the official names of this protein?
Defensin-like protein 2, Cysteine-rich antifungal protein 2, AFP2, RAFP2.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2004_STAA8
Sequence: MVRESIPKEGENIKIQSYKHDGKIHRVWSETTILKGTDHVVIGGNDHTLVTESDGRTWITREPAIVYFHSEYWFNVICMFREDGIYYYCNLSSPFVCDEEALKYIDYDLDIKVYPNGKYHLLDEDEYEQHMNQMNYPHDIDIILRRNVDILQQWIEQKKGPFAPDFIKVWKERYKKIRQY
What are the official names of this protein?
UPF0374 protein SAOUHSC_02004.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: DUT_ACICJ
Sequence: MTIAVAVKRLAHGAGLPLPDYATAGSAGLDLLAAVDAPVVIAPGARALVPTGLAIALPPDFELQVRPRSGLALKHGIVIPNSPGTIDSDYRGEIQVIVLNAGTEAFEVTRGMRIAQAVLAPVSRLVWQETDDLDRTAREAGGFGSTGLDFPMGN
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RDH12_BOVIN
Sequence: MLVVLGLLTSFLSFLYVIAPSIRKFFAGGVCRTDVQLFGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIQADTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMLCPYSKTADGFETHLAVNHLGHFLLTHLLLGRLKESAPARVVNLSSVAHHLGKIRFHDLQGDKYYNLGFAYCHSKLANVLFTRELAKRLKGTGVTTYAVHPGIVRSKLVRHSFLLCLLWRLFSPFLKTTWEGAQTSLHCALAEGLEPLSGKYFSDCKKTWVSPRARNNKTAERLWNVSCELLGIRWE
What is the function of this protein?
Retinoids dehydrogenase/reductase with a clear preference for NADP.  Displays high activity towards 9-cis, 11-cis and all-trans-retinal.  Shows very weak activity towards 13-cis-retinol.  Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal.  May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation.  Has no dehydrogenase activity towards steroids.
What are the official names of this protein?
Retinol dehydrogenase 12, Double substrate specificity short-chain dehydrogenase/reductase 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: HUNB_BOMMO
Sequence: IGGIPAANAKCASHAGMTPAPHSSHPQAWGPLLQPPTVKTEPMDDGNFSKEQTSGFYSEGFHSASPSSSSKDSNGHSPRSSGSTREPSPFYDAMPLKAKANLGMHLDSFRNSLPYSLLTPPGFESRASDARDHSPSYESYSPRTLAPPAHVSHPLGRSDATPPKSPPRTPSSPERRSFDRFHDSGFDGVDHNKHDGDDGREGSGLEDDFDEEPGLRVPAVNSHGKVKTFKCKQCEFVAVTKLSFWEHSKEHIKPEKMLCCRKCPFVTEYKHHLEYHMRNHMGSKPFQCSQCSYSCVNKSMLNSHLKSHSNVYQYRCADCNYATKYCDSLKLHLRKYQHNPAMVLNLDGTPNPLPIIDVYGTRRGPKQKPLSKIFEQQTGTNNHSP
What is the function of this protein?
Gap class segmentation protein that controls development of head structures.
What are the official names of this protein?
Protein hunchback.
What is the protein family that this protein belongs to?
Belongs to the hunchback C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MXMT2_COFAR
Sequence: MELQEVLHMNEGEGDTSYAKNASYNLALAKVKPFLEQCIRELLRANLPNINKCIKVADLGCASGPNTLLTVRDIVQSIDKVGQEEKNELERPTIQIFLNDLFQNDFNSVFKLLPSFYRKLEKENGRKIGSCLISAMPGSFYGRLFPEESMHFLHSCYSVHWLSQVPSGLVIELGIGANKGSIYSSKASRPPVQKAYLDQFTKDFTTFLRIHSKELFSRGRMLLTCICKVDEYDEPNPLDLLDMAINDLIVEGHLEEEKLASFNLPFFTPSAEEVKCIVEEEGSFEILYLETFKAHYDAGFSIDDDYPVRSHFQVYGDEHIKAEYVASLIRSVYEPILASHFGEAIMPDLFHRLAKHAAKVLHLGKGCYNNLIISLAKKPEKSDV
What is the function of this protein?
Involved in the biosynthesis of caffeine.  Catalyzes the conversion of 7-methylxanthine (7mX) to theobromine and with a lower activity of paraxanthine to caffeine (PubMed:12746542, PubMed:12527364, PubMed:18068204).  Does not have 1-N-methylation activity (PubMed:12527364).
What are the official names of this protein?
Monomethylxanthine methyltransferase 2, CaMXMT2, 7-methylxanthine N-methyltransferase 2, Theobromine synthase 2, Theobromine synthase 3.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
Protein: RS7_CALS4
Sequence: MPRKGPVPKREVLPDPVYNSVKVAKLINKVMWDGKKSLAQKICYGAFDIIREKTGRDPLEVFEEALNNVMPVLEVRPRRVGGATYQVPMEVRPERRLSLGIRWIVEYARQRSGKSMMEKLAAEIIDAANNTGGSVKKKEDTHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SYE_HERA2
Sequence: MSDRPTPARTRFAPSPTGYLHIGSLRTVLFSWLWARHTGGQFLLRIEDTDRKRFVEGAEEQLTSSLQAIGLMWDEGPIVGGPHAPYKQSERLEIYQAHAQALIDKGVAYRSYATADEIAAINAEREARGEPKLLVFRNLPGIDDAAREAAGADYNVRLSLKTTGQTVVQDLVRGQIVFDNAALKMPDPVLLKTDGFPTYALAAMVDDHLMGITHVLRADEWIPTWPIHHQIYEAFGWEQPVWVHVPQVLGSDGKKLSKRHGDTSVTEYIDLGFVPEAIINYLALIGWSYDDKTEFMTLEELIERFDLNRIRPSGGVFDRDKLLHFNGVYLRNMAPAELAQRVAPYLSKAGLISAEPTAAELAKITEYLPLVQDRLKLLSEAPELLDFFFVDPQGYDPALLVPKKGDPAQTVEILGQVKASFEAVETWDAPSLDKLLHDFVNQLGLKIPQVFMPIRVAISGRTTSPGLFETLAVLGKAVTLARISTAAAALSSASV
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGCY_HEDDI
Sequence: MFKDYSREKFAKENFPDLSKHNNVMASHLTYELYEKYWDKVTPNGVTLDKCIQTGVDNPGNKFYGKKTGCVFGDEHSYETFKDFFDRVIEEIHHFKPEDVHPATDLDETKLVGGVFDEKYVKSCRIRCGRSVRGVCLPPAMSRAERRLVEKVVSNALGGLKEDLAGKYFPLTTMNDKDMEALIEDHFLFEKPTGALLTTSGCARDWPDGRGIWHNNGKNFLVWINEEDHIRIISMQKGGDMRAVFSRFGRGLTEVERLMKEKGYELMRNERLGYICTCPTNLGTVVRASVHLRLANLEKDKRFDDFLAKLRLGKRGTGGESSLAEDSTYDISNLARLGKSERELVQVLVDGVNVLIEADKRLEAGKPIDDLTPRLNSSTGTSISATASRHMTL
What are the official names of this protein?
Glycocyamine kinase, GK, Guanidinoacetate kinase.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: PSTB_OLEA2
Sequence: MASLTKMHSKGLDFFYGDFQALHDISLEFSNNQVTALIGPSGCGKSTFLRCLNRMNDLIPISRVEGEICLDNDNIYDPQVDVVELRRRVGMVFQKPNPFPKSIYENVAYGLRVNGVKDKNCLEDKVEESLRHAALWDEVKDRLHDSALGLSGGQQQRLCIARALAVEPEVLLMDEPASALDPIATQKIEELIHTLKQKYTIIIVTHSMQQAARVSDVTAFFYMGRLIETGDTEVMFTRPGNKQTEDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RAC1_MOUSE
Sequence: MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
What is the function of this protein?
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states (PubMed:24352656).  In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles.  Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages.  Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.  Stimulates PKN2 kinase activity.  In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts.  In glioma cells, promotes cell migration and invasion.  Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.  In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning.  In neurons, is involved in dendritic spine formation and synaptic plasticity (PubMed:24352656, PubMed:26969129).  In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502).  In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.  In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity).
What are the official names of this protein?
Ras-related C3 botulinum toxin substrate 1, p21-Rac1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasm. Cell projection, lamellipodium. Cell projection, dendrite. Synapse. Nucleus. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C- terminal cysteine (By similarity). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts (By similarity). Localizes to the lamellipodium in a SH3RF1-dependent manner. In macrophages, cytoplasmic location increases upon CSF1 stimulation (PubMed:17116687). Activation by GTP-binding promotes nuclear localization (By similarity).