PharMolix/UniProtQA huggingface dataset:
Protein: ETHR_MYCS2
Sequence: MTTASQTRTPRGRRSARPSGDDREAAILATAQRLLETKKFAEISVDDLAKGAGISRPTFYFYFPSKEAVLLSLIDPLIKRADSGFDNAVESMPADPQRAIRRGIEIFFNSFGSHPATARAGTEALKSSPEFKEFWSGLMQKWIAATAALITAERERGAAPDTIPALDLATSLNLMNERTMMAALADEQPGVAPEKVVATLTHIWLNSIYGTLPVGTA
What is the function of this protein?
Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).
What are the official names of this protein?
HTH-type transcriptional regulator EthR.
Protein: MED8_CANAL
Sequence: MSQTPFNPNSPSVPTTTSLPSTDFSQIPYDVLESIRNRLNQIRQSLTKLADQINNHNRHPQKIKLPSYSYFQNQFQVLITQLMSITNQLYNNEDLLRNTNVYPTPIFPTSAHENMLTTLLRKKVAPEVDEWINGAKLIMENETKNKLDNQQVEIDILKIDQWVQWCLAKIQDLRDEFQFYGFHTVEELDHMETPQGKQEIKEKKDKEFEREQIELKITAGGQKSLHPNQVLKFMCQGQI
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 8, Mediator complex subunit 8.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 8 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYFA_ACISJ
Sequence: MNELDSLVTSARESFARSATPAELENAKAQFLGKSGRLTELMKGMAQLSPEEKKTRGAAINVAKQAVEAALAARRQELADAELQAQLKAEALDVTLPGRQRGRGGLHPVSLTLERIERIFGSMGFEVADGPEIETDWFNFTALNTPEDHPARSMHDTFYVEGGTPEAPNLLRTHTSPMQVRYAVQHVKKHRGLIDAGQAMPEIRVIAPGRTYRVDSDATHSPMFHQCEGLWIGENVSFKDLKVVFTDFCKTFFESDDLVLRFRPSFFPFTEPSAEIDIQFQSGPLAGKWLEVAGSGQVHPNVVRNMGLDPERFIGFAFGMGPDRLTMLRYGVNDLRLFFDGDIRFLSQFQ
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_LAWIP
Sequence: MKVLVINTGSSSFKYQLIDMPMEQVLVSGLVERIGEEVGQMVHKIYPNTSQEKKYTTTQPFSTHVEGMQAVVAELINPKHGILHSVKEIYAIGHRVVMGGETMKHPALINQHVKNIIRECAIFSPLHNLSHLAGIETAEELFPGIPNVAVFDSEFHQTMPKVAYLYPLPYDIYDDYKIRRYGFHGTSHRYVAQQTANFLNRPIKELNFITCHLGNGCSMTAIKNGKSIDTSMGLTPLDGLMMGTRCGDIDPAIVPFLIEKTEKSAKDVDELMNKQSGLKGICGMNDMRDIHEACAQGNAKAQLALDMFIYRIKKYLGAYYAILGHLDGIIFTAGIGENDTIVREKVCSGLENLGIFLDSSRNNTHSSTLRLISTDNSPIPIFVVPTNEELEIAKLTIQLVSNTQ
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEY1_PLAKH
Sequence: MQMDRKTQIIDYDGNMIADLKEWMIRNKLANLGFNYNVVAILGSQSSGKSTLLNNLFKTSFDVMNTKLGHSQTTQGLWLSFDTFEESPVSPLEKGNSTTPINPTLILDVEGNDSKERGDNRLTFEHRSALFSLALADCLIVNLWYHSLGNFTASNYGLLKTVMEVNLELFQQDKNCPKTILLFTVRDWFEEFASIDIVKNKIVEEYLNKIWAEMKKPPSAKKANINNYFIVEVVGLSHAIIKKTEFLNDVENLRKKWINELRPLQYSRNIPSDGFAHYCNNIWNTIVKQSQLDIPSQKEMLATFRCQEIKNNVISNTSKMIKEKLTASSSQPTSASIDEFKSWAEKDIVEKSLDEYFVDASRYTESICLKTSEELLESLFIQLQTIVDNNLNFTQRVLSAKFANELNTMYSVCTSDKNVFLFSKESNLQVHKDGNGSNSSKEDKKDENTSQDKCIRLWSSFLSNADKLEYITFCNFFESYQKCNIEIRKKNKIHEFNYKPSLNILLTSICKDMNRIRNTQFTVLLERTRATIKSRFKNMDNLLITTKNPEEYWNHTLKIVKALQESINNNLTKCFINLKGGGPGSSVAGISNELFDHDEDNTFHVDSPSEGHRSISDNRTAHENKHYVDENLLNYKKIDIIKNKGKYISSVSEEIDKQIKNKKAISELNNYYLDEIMDVLKSKLDEISDNLSSIIIQRFESVFNYDDAEQPRHWREISMAELKKIFRESKNYAFLIIDILQKNIKVELIDDYLPNNFIKDEVIEKGKNKAKRKIQEICRDAQYIQETGGKMSLKNVPLFFWVILLILGWNELLFFIRFFFRLNIILPLFLAAAVILSTLFFNGNMEVLSTINKVVFFLAKSSFGFYRQLQTMGEKVAQVPTAD
What is the function of this protein?
Probable GTP-binding protein involved in generating and maintaining the structure of the tubular endoplasmic reticulum network.
What are the official names of this protein?
Protein SEY1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GATC_ARATH
Sequence: MATRALLAVIYASPNRCYISPSRIKIQSLTCSSSSHYYQRQSRKNHRIARSYSSDSDSSVLQPPDVARLAQTARISLTPAEIEECETKIRRVIDWFGQLQQVDVNSVEPAIRAEMDGGNLREDAPETFDNRDSIRASIPSFEDAYLKVPKILNKE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, chloroplastic/mitochondrial, Glu-AdT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
What are the subcellular locations of this protein?
Mitochondrion. Plastid, chloroplast.
Protein: TRMD_SHESR
Sequence: MWLGVITLFPEMFRAVTDFGVTGRAVKNGLLELHTWNPRDFTHDRHSTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEEAKVIYLSPQGRKLDQQGVTELAESSRLILVCGRYEGIDERIIQTEVDEEWSVGDYVLSGGELPAMTLIDAVSRLVPGVLGKQASAEQDSFSDGLLDCPHYTRPESLDGLDVPAVLLSGNHEQIRLWRLQQSLGRTFLRRPELFENLALTDEQSTLLAQFVEAMDKNA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBB_OENEH
Sequence: MGLPWYRVHTVVLNDPGRLLAVHIMHTALVAGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWSITGGTVTNPGIWSYEGVAGSHILFSGLCFLAAIWHWVYWDLAIFSDERTGKPSLDLPKIFGIHLFLSGLACFGFGAFHVTGLYGPGIWVSDPYGLTGEVQPVNPAWGVEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVGAGLAKNQSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDSGDGIAVGWLGHPIFRDKEGRELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTIEFYGGELNGVSYSDPATVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDTQVEFGAFQKLGDPTTRRQAV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RS15_THISH
Sequence: MSLNAETKAGIVEKYRRDPSDTGSPEVQVALLSARIDHLMGHFASHKKDHHSRRGLLKMVNQRRKLLDYLKSQDQQRYQDLVSSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SPAST_DROSI
Sequence: MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGVGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEARSKPQKSREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTARPKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI
What is the function of this protein?
ATP-dependent microtubule severing protein.  Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle.  Regulates microtubule stability in the neuromuscular junction synapse.  Involved in lipid metabolism by regulating the size and distribution of lipid droplets.  Involved in axon regeneration by regulating microtubule severing.
What are the official names of this protein?
Spastin.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Spastin subfamily.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Chromosome. Lipid droplet. Note=Forms an intramembrane hairpin-like structure in the membrane. Colocalizes with cellular microtubule arrays. Localizes to chromosomes from prometaphase/metaphase to anaphase, and this requires microtubules. Localizes to discrete punctate cytoplasmic foci which may correspond to secretory vesicles.
Protein: PUR5_VIBCH
Sequence: MSGNNPSLSYKDAGVDIDAGNALVERIKGAVKRTRRPEVMGGLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLALDMKKHDTIGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDTAAEVISGIADGCLQAGCALIGGETAEMPGMYEGEDYDVAGFCVGVVEKEEIIDGSKVQVGDALIAVGSSGPHSNGYSLVRKILEVSKADKNERLAGKTIGEHLLAPTKIYIKSGLKLIAEHDIHAISHITGGGFWENIPRVLPEGTKAVIDGKSWEWPVIFQWLQEKGNVTTHEMYRTFNCGVGLIIALPKDQANAAVALLQAEGETAWVIGEIAAANSNEAQVEIN
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OCTN2_MOUSE
Sequence: MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESCLDGWEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGVPLPDTIDQMLRVKGIKQWQIQSQTRMQKDGEESPTVLKSTAF
What is the function of this protein?
Sodium-ion dependent, high affinity carnitine transporter.  Involved in the active cellular uptake of carnitine.  Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:20722056).  Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium.  Also relative uptake activity ratio of carnitine to TEA is 11. 3 (PubMed:10454528).  May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity).
What are the official names of this protein?
Organic cation/carnitine transporter 2, High-affinity sodium-dependent carnitine cotransporter, Solute carrier family 22 member 5.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Protein: RS5_ACET2
Sequence: MQRIDASVLDLKEKVVNIGRVTKVVKGGRNFRFSALVVVGDENGHVGSGMGKAAEIPDAIRKGIEDAKKNLIKVPIVNTTIPHEVIGEFGAGKVLLKPAQPGTGVIAGGPVRAVLELAGIKDIRTKSLGSNNPINMVHATIEGLSRLKTAEEVAKLRNKTVEEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: SUB2_ASHGO
Sequence: MSHEGEEDLLEYSDNEQEIQVDNTKATEVAGNGEEAADGKDGDKKGSYVGIHSTGFKDFLLKPELSRAIIDCGFEHPSEVQQHTIPQSIHGTDVLCQAKSGLGKTAVFVLSTLQQLDPVPGEVSVVVLCNARELAYQIRNEYLRFSKYMPDVKTAVFYGGTDTRKDIELLKNKDTAPHIVVATPGRLKALVRDNNIDLSHVKNFVIDECDKVLEELDMRRDVQDIFRATPRDKQVMMFSATLSQEIRPICRRFLQNPLEIFVDDEAKLTLHGLQQYYIRLEEREKNRKLAQLLDDLEFNQVIIFVKSTLRANELTKLLNASNFPAITVHGHMRQEERIARYKAFKEFEKRICVSTDVFGRGIDIERINLAINYDMPSEADQYLHRVGRAGRFGTKGLAISLVSSKDDEEVLAKIQERFDVKITEFPEEGVDPSTYLNT
What is the function of this protein?
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus.  SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly.  May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase SUB2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PUR5_LYSSC
Sequence: MSKAYEQAGVNIEAGYEAVKRMKSHVERTNRLGVMGTFGGFGGMFDLSELNLKEPVLISGTDGVGTKLKLAFMVDKHDTIGVDCVAMCVNDIVAQGAEPLYFLDYVALGKAEPAKIEQIVKGVADGCVQSGAALIGGETAEMPGLYEEDEYDLAGFAVGACEKSAIVTGERIVEGDVLIGIASSGVHSNGYSLVRKIVFADRQYAVDAIVENYEDLGPIGEALLVPTKLYAKPVLAALKAADVHGCAHVTGGGFYENLPRMMPEGLATEIDLGSWPVLRIFEFLKDKGQLEDKDLYNVFNMGIGFVIAAPAAEADKVMAAVEANGEKAYTIGRVIKGNGVVFNGTHDGSLV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSPD_ECOLI
Sequence: MKGLNKITCCLLAALLMPCAGHAENEQYGANFNNADIRQFVEIVGQHLGKTILIDPSVQGTISVRSNDTFSQQEYYQFFLSILDLYGYSVITLDNGFLKVVRSANVKTSPGMIADSSRPGVGDELVTRIVPLENVPARDLAPLLRQMMDAGSVGNVVHYEPSNVLILTGRASTINKLIEVIKRVDVIGTEKQQIIHLEYASAEDLAEILNQLISESHGKSQMPALLSAKIVADKRTNSLIISGPEKARQRITSLLKSLDVEESEEGNTRVYYLKYAKATNLVEVLTGVSEKLKDEKGNARKPSSSGAMDNVAITADEQTNSLVITADQSVQEKLATVIARLDIRRAQVLVEAIIVEVQDGNGLNLGVQWANKNVGAQQFTNTGLPIFNAAQGVADYKKNGGITSANPAWDMFSAYNGMAAGFFNGDWGVLLTALASNNKNDILATPSIVTLDNKLASFNVGQDVPVLSGSQTTSGDNVFNTVERKTVGTKLKVTPQVNEGDAVLLEIEQEVSSVDSSSNSTLGPTFNTRTIQNAVLVKTGETVVLGGLLDDFSKEQVSKVPLLGDIPLVGQLFRYTSTERAKRNLMVFIRPTIIRDDDVYRSLSKEKYTRYRQEQQQRIDGKSKALVGSEDLPVLDENTFNSHAPAPSSR
What is the function of this protein?
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane.  This subunit would form the outer membrane channel.
What are the official names of this protein?
Putative secretin GspD, Putative general secretion pathway protein D, Putative type II secretion system protein D, T2SS protein D.
What is the protein family that this protein belongs to?
Belongs to the bacterial secretin family. GSP D subfamily.
What are the subcellular locations of this protein?
Cell outer membrane. Note=Most of the protein is in the periplasm which it traverses to contact proteins of the cell inner membrane.
Protein: Y2138_YERPP
Sequence: MQIWVDADACPNVIKEVLFRAADRTGMMVTLVANQPLKTPPSKFIRTVQVASGFDVADNEIVQRVEKNDLVITADIPLAAEVIEKGGIALNPRGERYTPDTIRERLNMRDFMDTMRASGIQTGGPNTLNQRDRQQFANELDKWLQQARNQAK
What are the official names of this protein?
UPF0178 protein YPDSF_2138.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: RIHA_SHIB3
Sequence: MALPILLDCDPGHDDAIAIVLALASPELDVKAITSSAGNQTPEKTLRNVLRMLTLLNRTDIPVAGGAVKPLMRELIIADNVHGESGLDGPALPEPTFAPQNCTAVELMAKTLRESAEPVTIVSTGPQTNVALLLNSHPELHSKIARIVIMGGAMGLGNWTPAAEFNIYVDPEAAEIVFQSGIPVVMAGLDVTHKAQIHIEDTERFRAIGNPVSTIVAELLDFFLEYHKDEKWGFVGAPLHDPCTIAWLLKPELFTTVERWVGVETQGKYTQGMTVVDYYYLTGNKPNATVMVDVDRQGFVDLLADRLKFYA
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihA, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihA subfamily.
Protein: Y309_CHLTR
Sequence: MNQCYFLSSFLSPQQPESPPLYSFQEINDLLALNFTDKDWQSYVILRRFFDLENFAFFWAGKSIPFSFGTITNSNVESLLRLQMWSDEWEFEDFFKDFLLRYKTPQERLTHFSELVRDFLDHYQDYPSEFLRTYFRFKQDLRIILAGFRARVMQKDVSFVLRDEDSSNPIVLHVLMQKDSPNYELPDEFFELRDVLGDYGRLPHMLNQTLSFYEFHKVEEMSRDKYLNTDAILSRLTTYLMAIRSSWASVQKGKELINLMEKGIRW
What are the official names of this protein?
Uncharacterized protein CT_309.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0087/CT_309/TC_0583 family.
Protein: Y1938_STAAC
Sequence: MAMTNEEKVLAIREKLNIVNQGLLDPEKYKNANEEELTDIYDFVQSRERLSPSEVTAIADALGQLRHE
What are the official names of this protein?
UPF0435 protein SACOL1938.
What is the protein family that this protein belongs to?
Belongs to the UPF0435 family.
Protein: HRCA_CYAP4
Sequence: MQVRLNERQQQVLWATVRHYIATAEPVGSKALAEEYNLKVSAATIRNIMGALEQGGLLYQPHTSAGRVPSDSGYRIYVDYLMTPANDLSRRVEQLLSDRLNPTSISLEAVLRGAAQILATLSGYITLITLPQTLTATIRWLQLVRVETSRVMLIVVTDNYETRSALMELGDTADTEESRIERELEVLTNFLNHQLRGRSLTELANLDWQQLDREFQRHGDTLRTLLQDLLQRSQPVGSNQILISGLSEVLQQPEFSQLQQVQTILHLLEDEQDQLWPLICEWSVATDAAPITLPSQQRVRILIGSENPLEPMRMCTLVSSTYQRGSVPIGSVGVLGPTRMPYDKVIPLVEATADYLSDTLGQPA
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: PUR1_SYNY3
Sequence: MFPPSSDLTELNDGQPLSGHHADKPEEACGVFGIYAPEEAVAKLTYFGLYALQHRGQESAGIATFAGTTVHCHKDMGLVSQVFQESKLNEMVGTLAVGHTRYSTTGSSHRVNAQPAVLPTRLGPLALAHNGNLVNTNQLREALAERGCEDFVTTTDSEMIAVAIANEVDKGKDWVEGTIAALTLCAGAYSLVIGTPEGIIGVRDPHGIRPLVIGVLEEETPRYVLASETCALDIIGATYVRTVEAGELVHITESGLVSHRLAESADRKLCVFEMIYFSRPDSVVNDESLYTYRMRIGKHLAKESPVDADLVMGVPDSGIPAAIGFSQASGIPYAEGLIKNRYVGRTFIQPTQHMREHGIRMKLNPLKDVLAGKRIIIVDDSIVRGTTSRKIVRALREAGATEVHMRISSPPVTHPCFYGIDTDSQDQLIAARLTVAEIAEQIEVDSLAYLSQEGMLLCTGEDISHFCSACFNGRYPITVPDAVRRSKLMLENITA
What is the function of this protein?
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
What are the official names of this protein?
Amidophosphoribosyltransferase, ATase, Glutamine phosphoribosylpyrophosphate amidotransferase, GPATase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: SMN_MOUSE
Sequence: MAMGSGGAGSEQEDTVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETPDKPKGTARRKPAKKNKSQKKNATTPLKQWKVGDKCSAVWSEDGCIYPATITSIDFKRETCVVVYTGYGNREEQNLSDLLSPTCEVANSTEQNTQENESQVSTDDSEHSSRSLRSKAHSKSKAAPWTSFLPPPPPMPGSGLGPGKPGLKFNGPPPPPPLPPPPFLPCWMPPFPSGPPIIPPPPPISPDCLDDTDALGSMLISWYMSGYHTGYYMGFRQNKKEGKCSHTN
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.  Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits (By similarity).  Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development (PubMed:23063131).  Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination.  May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs) (By similarity).
What are the official names of this protein?
Survival motor neuron protein.
What is the protein family that this protein belongs to?
Belongs to the SMN family.
What are the subcellular locations of this protein?
Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with actin and at the Z-line of skeletal muscle (PubMed:17353360). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules. Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies. Colocalizes with FMR1 in cytoplasmic granules in the soma and neurite cell processes (By similarity).
Protein: RS8_MOUSE
Sequence: MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKGK
What is the function of this protein?
Component of the small ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
What are the official names of this protein?
40S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Lipid-anchor. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: RL16_HERA2
Sequence: MLMPKQMKYRRPHRPRNIKGIAQRGATVAFGDFGLVSLEAGWITSRQIESARRTITNYVKRGGKVWIRIFPDRPITQKPAETRMGSGKGSVEYYVAVIKPGRVLFELNGVPEDVAQEALRRAAQKLPVKCKFVTKASQEVGSNEG
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: SHAKB_DROME
Sequence: MLDIFRGLKNLVKVSHVKTDSIVFRLHYSITVMILMSFSLIITTRQYVGNPIDCVHTKDIPEDVLNTYCWIQSTYTLKSLFLKKQGVSVPYPGIGNSDGDPADKKHYKYYQWVCFCLFFQAILFYTPRWLWKSWEGGKIHALIMDLDIGICSEAEKKQKKKLLLDYLWENLRYHNWWAYRYYVCELLALINVIGQMFLMNRFFDGEFITFGLKVIDYMETDQEDRMDPMIYIFPRMTKCTFFKYGSSGEVEKHDAICILPLNVVNEKIYIFLWFWFILLTFLTLLTLIYRVVIIFSPRMRVYLFRMRFRLVRRDAIEIIVRRSKMGDWFLLYLLGENIDTVIFRDVVQDLANRLGHNQHHRVPGLKGEIQDA
What is the function of this protein?
Structural component of the gap junctions at electrical synapses in distal and mid-depth levels in the lamina.  Isoform Lethal forms voltage sensitive intercellular channels through homotypic interactions.
What are the official names of this protein?
Innexin shaking-B, Protein passover.
What is the protein family that this protein belongs to?
Belongs to the pannexin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.