PharMolix/UniProtQA huggingface dataset:
Protein: RET3_HUMAN
Sequence: MMREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENLLGMQEAIQQAIKSHEILSISDPQTLASVLTAGVQSSLNDPRLVISYEPSTPEPPPQVPALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPGQEVLSMMGEFLVAHVWGNLMGTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEIWTLPQVLGERYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDFFFTVPVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQEVLKDYYTLVDRVPTLLQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPAPDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADASVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPEAGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDKAQEVLEFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESLASQLTADLQEVSGDHRLLVFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVRLVWQQLVDTAALVIDLRYNPGSYSTAIPLLCSYFFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLAGVEPDITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRYSRVTSEVALAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIKFSFHTNVLEDNIGYLRFDMFGDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPTSSIPILCSYFFDEGPPVLLDKIYSRPDDSVSELWTHAQVVGERYGSKKSMVILTSSVTAGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYLTIPTARSVGASDGSSWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL
What is the function of this protein?
IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
What are the official names of this protein?
Retinol-binding protein 3, Interphotoreceptor retinoid-binding protein, IRBP, Interstitial retinol-binding protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S41A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
Protein: ACRB_ASPNC
Sequence: MPRSSATARKSHSNRHENGLVGPGKKVNKQKSNGNLNGNTNGASAPNSGPSTQVDWPASRSSSDSALTSSATTASKVNGSADTSKADGNGRGLLNGYAKGNADMSYGQTNGAVPQNGGLAGQASRRTEKPATGSKKSGSINPLQLASTILKSCPMYDTIAILIFLLQLPPMVLTLVQFLFASLTFMPPSGASSGSLTSNFDIFQGPAGTPSLGTMIAMDGFCLLFWGLFMWTWAQNFALDLAHVQVAITLGGGGSGKNGGVNALCVGIVLVLHLIRSKGIQDFVIGHLLSAKIVSPDFLSQYSHLMPPEFRRTEPQSSPSWMRSLLAVHILAQAGTAMARRSMAKNRSPAPPRNGKRVDTEASAGSQTQIDSAFESGASVSSYIGADGQLVTPATHKDGRDRLMSAKKRRRQANQVRSRQPFWAALASTKVTVMREYEHSRALNKTGRGLMMTEEDLQGISLDDGLVWITEVDSSTIKFAAGDFSSVDDPALAGVCETARLGNDETEPFYVCVNGALWATATITKVQDAPKGSNTVHWRGEVSGLAPNCAYTCSFVRSDTDEEICVMSVKTPAATDAEQVSSIPTPPQPSYRPSSPTTTLKNSIVNAEVKLNEKRARLRKAKNDHKLVISKIRKELDNYNHRLQSGTDENRQKQRSLQLERNIKQTEEITAALESQLDNLENIPEEELEEWSTQKSKYEQELEQLNLAKEELVSARAAVAREVSSLESELNSAIQRKERLQGRRTRVNEQYERIVSANAQGLNERERRAAEQFAREQDQAKLEANFHEQFASISQSVQEYQVRTNQLWQQAAAIEQAIQQQQQQMLLDSAPLTPEGNLPGTNPLTEAPGMSLGALTTTAPNTRSLLGLSFPSLKSSPLQHASSPVGAASSHPTSPTQPPSYLQHFPTSPLGNTGNYFDMDFTYRDRSFSNRSAHSSLYGADFLDSNRRGPFQLDLSDTVIEKRMDSGSEGVTPNPIMRPISTPFQRADSRGSGSGSGSSGASGSGSGSPSSTGGKGN
What is the function of this protein?
Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  Involved in resistance to acriflavine, and required for normal growth on a range of sole carbon sources, including fructose, cellobiose, raffinose, and starch, and reduced utilization of amino acids, including GABA and beta-alanine, as sole carbon and nitrogen sources (By similarity).
What are the official names of this protein?
Probable ubiquitination network signaling protein acrB, Acriflavine resistance protein B.
What is the protein family that this protein belongs to?
Belongs to the acrB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PLSX_SHEWM
Sequence: MTDLTLALDVMGGDYGPRVTVPATLQALHLYPSLHVVLVGNQPEIEHFLPKAESSIRQRIEILHTTEVVSMSDRPVHALRNRKQSSMRLAIELVRDGKAQACLSAGNTGALMAIAKVLLKTLPGIDRPALVSCLPAVNQKPVYLLDLGANVSCCSETLFQFAVMGSVLSEAVDKNEQPKVALLNVGIEEIKGNDQVQQAGQLLQQSPQINYVGFIEGNDLYSGNVDVIVCDGFVGNITLKTSEGIAKLLVNQLEKGLTKGFFVRLMAKLIAPRINSVLKQMNPDHYNGASLIGLRGIVVKSHGSADESAYLQAITLAVTEAQRRLPKMIEERLESILLDINN
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: PFKA_HAEI8
Sequence: MIKKIAVLTSGGDAPGMNAAIRGVVRSALAEGLEVFGIYDGYQGLYNNKIKQLNRYSVSDVINRGGTFLGSARFPEFKDPNVRAKCAEILRSHGIDALVVIGGDGSYMGAKLLTEEHGFPCVGLPGTIDNDVAGTDYTIGYQTALQTAVDAIDRLRDTSSSHQRISIVEIMGRHCSDLTISAGIAGGCEYIVASEIEFNREELIQQIERSIIRGKRHAIIAITELLTDVHSLAKEIEARVGHETRATVLGHIQRGGSPCAFDRILASRMGAYAVDLLLQGKGGYCVGIQNEQLVHHDIIDAINNMQRVFKADWLKVAKRLE
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_SULDN
Sequence: MARSVKKGPFVDDHLMKKVLSAKAEGSKKPIKTWSRRSMVLPDMVGITFNVHNGRQFVPVYVTENHIGYKLGEFAPTRTFKGHKGSVQKKG
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: FTSH_PARP8
Sequence: MDFNREHKINFLYVLAAMVGVLLIQSLVSQPDHIRTIPYSEFQQLASQGKVTDLVVGPTRITGTLKDAPKDSPRHFSTLRVDQALAQSLTNENVTFSGEPEPGPWPTILGWLMPIVGFALVWMFLIRPMSMGPGMDGMMSIGKSKARVYVEKDIKVTFADVAGVDEAKDELKEVVSFLRDPRSYGRLGARVPKGVLLVGPPGTGKTLLARAVAGEAGVAFFSISGSEFVEMFVGVGAARVRDLFEQARKHAPAIVFIDELDSLGRARGSAFPGGGGHDEKEQTLNQLLAELDGFDTSIGVVLLAATNRPEILDPALLRAGRFDRQVLVDRPDKKGRAQILEVHLKKIALAPGVPVDDIAALTPGFSGADLANLVNEAAILATRRHAENVSLDDFTQAIERIVAGLEKRNRLLNAHEREVVAHHEMGHALVAMTLPGVDMVQKISIIPHGIAALGYTIQRPTEERFLMDRAELMNRMAVLLGGRAAERLIFADVSTGAADDLAKASAIARSMVVRFGMDPTLGQVAYEPETTSALGLPNGSEWRPRQYGEQTAAAIDAAVRELIETASACAFSILQANRGLLESAARDLLAKETMSGEELQALLSQLGGGAASASVLRDGGDGAADAGQDRSGEHRALTVEGGEAQ
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: SODC2_MESCR
Sequence: MGVIKAVAVINGNNNVKGSLQFIQDSTGVTHVKGRITGLTPGLHGFHIHALGDTTNGCNSTGPHFNPLKKDHGAPFDTERHAGDLGNVVAGADGVAEVSVRDTQIPLSGQHSILGRAVVVHADQDDLGRTGHELSKTTGNAGARVRCGIIGLQASV
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn] 2.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEOC_SALA4
Sequence: MASLIQVRDLLALRGRMEATQISHTLHAPQPMIDAMLNQLEIMGKAVRIPEEADGCLSGSCKSCPEGKACLREWWALR
What is the function of this protein?
May function as a transcriptional regulator that controls feoABC expression.
What are the official names of this protein?
Probable [Fe-S]-dependent transcriptional repressor.
What is the protein family that this protein belongs to?
Belongs to the FeoC family.
Protein: YAOL_ARATH
Sequence: MKLEKKKGIGAKRRGKKSSIDHDPFLEEETEKRRKFNYDDDDDIESVESEEEGKVGEEVEDEFAHETVGEKRKRLAEDTLNRIEEAKQREHEEDNEEDDDFRDSLVAKTLMQEQLEKSGRVRRANALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKSDEYKWPSDEVLKSHGLKFQESWYTRHNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRTYIESCFGHQSELLSIDALGRERVLSVGRDRTMQLYKVPESTRLIYRASESNFECCCFVNSDEFLSGSDNGSIALWSILKKKPVFIVNNAHHVIADHDSVNHNCTPACSWVSSVAVCRGSELAASGAGNGCVRLWGVESGSSAIQPLYELPLPGFVNSLAFAKSGRFLIAGVGQEPRLGRWGCLKSAQNGVAIHPLRLS
What is the function of this protein?
Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (By similarity).  Essential for embryogenesis (By similarity).  May function during late embryogenesis (PubMed:20699009).
What are the official names of this protein?
U3 snoRNP-associated protein-like EMB2271, Protein EMBRYO DEFECTIVE 2271, Protein YAO-like.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RRP9 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: UTER_NEOAS
Sequence: MKLAITIILVMLSVCYSSDTCPGFLQVLEYLFMGSESTYEAALKFYNPGSDLQNSGMQLKKLVDTLPEKTRVNIVKLSEIILTSNLCNQDPSF
What is the function of this protein?
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
What are the official names of this protein?
Uteroglobin, Club cell secretory protein, Secretoglobin family 1A member 1.
What is the protein family that this protein belongs to?
Belongs to the secretoglobin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NU5C_CHAVU
Sequence: MDFIFHYQSSWLIPMLPFLSAFVAGFGLISFRLPTRSLRHLYGLISTITVFFSMIISMNLLWKYIIGHSNYCFLFPWIVNDNISLKLGFFIDPLSSLMLFLVTSVAVLVMSYSHGYMSHDQSYVRFFAYLSLFTASMLGLVLSPNLFQIYIFWELVGMCSYLLIGFWFTRPNAASACQKAFITNRIGDFCLLLGILGLYWFTNSFDFITVTKRTEEIISNNNSHLYFFIFCSFLLFCGPIAKSAQFPLHIWLPDAMEGPTPISALIHAATMVAAGIFLVARLFPLFQLFPSIMNLITCIGILTAFLGSTIALSQIDLKKSLAYSTISQLGYMMVAMGIGSYKAGLFHLVTHAYSKALLFLGSGSVIHNLEPLLGYNPENNQNLVFMGGLGKSMPITRFTFLIGTLSLCGVPPFACFWSKDEIIADAWKYNFNLGLIAWITAGLTGFYMFRVYLLAFEGDFRGIIFLNKNNLKSTKEVHESNLYMLIPLIILSFLSLFIGFISTPFHDYLYIFLDSPIVYDNETSYFQILLNFSSIGVALIGMIIAYSIYAYNNISIDFGFFKRSLKKIYFEFYQFSFSKWYIEVFYHSLFLSGTRNLAQLLFYLDQWLFDGVVNLTGISTLLGGQSLKYKESGRVSSYLFSILIGALVLFFFLPLHNSQIGSN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: AIM21_CANAL
Sequence: MPDSEPLEPLNQESSSNTEQLKLSTTPNIPARPQTRPQKQSTTTTTTVPTDQDSTTETSLEKPLDNPQDELDELAHEIEKVLSDPVIPPRPQHGSSTKSSETQTEHKEHDFEPAHPAIPQRPTNKKETIQSEVGDHNNGLESKSDLKVNKETSDDSVSTDKDKVHIKPSIPTIPSRPQSRNLDFSEVDNTKPSTTPSIPARPQRQSTTTQDEYKPQASNTPDIVTRPQTKTEKSVSNEELDKPGDEPSSKDQDNERHTDDSNASKSILETEKAVAQEEKKAKKSDVDNKPSEPTTSTDSSTEPTAPARGFRLPLHMQQGSGPISTSTPVAGSEAELNSLNNSNTFGDGEVTPGNSDTKATFKNDEDVENENRTDSSSFDDDMETISQDNEDGEQDRRNRQETATEENAQESEAPQFETTIIESGETEERDGDDTDSGELYSEQQQNKEKEETVPATSTPKIPQRPPKKSSLSRATTNDSLTSLNSTSKPPKPVISKRPTTEESLSNIEPTIPSRPAINQIPSVGESQHEPIVPNRPGNKDLASSQKDTQVSVKSKPPPPKPKKLSSKIAAFQQQLFNPANASSEEDVSSTGSKQPESGIRKRSTENSVLSRFGGKAIPLPGMFNPNQMPKPSISHGEETSDDKEEKQESATANAPVRRTRGPRGKKLPKAVADAEVKTESRFAIESGKLWSIEFKKKIVEEKEIISTSVEDLKKPKILSENDEAGDESKETAVENEVIDNPEIPVKDELQHDVVDVVGHPEKDVVTGLDDDDEDVPPEVNERFIKDEEISNVGVERTIASETTTEKHSTDEEEVEEEAEVDSVDIPIRRVAVNTVDSTEVQKDVEDEP
What is the function of this protein?
Involved in mitochondrial migration along actin filaments.
What are the official names of this protein?
Altered inheritance of mitochondria protein 21.
What is the protein family that this protein belongs to?
Belongs to the AIM21 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch. Note=Cortical actin patches.
Protein: FEMA_STAAR
Sequence: MKFTNLTAKEFGAFTDSMPYSHFTQTVGHYELKLAEGYETHLVGIKNNNNEVIAACLLTAVPVMKVFKYFYSNRGPVIDYENQELVHFFFNELSKYVKKHRCLYLHIDPYLPYQYLNHDGEITGNAGNDWFFDKMSNLGFEHTGFHKGFDPVLQIRYHSVLDLKDKTADDIIKNMDGLRKRNTKKVKKNGVKVRYLSEEELPIFRSFMEDTSESKAFADRDDKFYYNRLKYYKERVLVPLAYINFDEYIKELNEERDILNKDLNKALKDIEKRPENKKAHNKRDNLQQQLDANEQKIEEGKRLQEEHGNELPISAGFFFINPFEVVYYAGGTSNAFRHFAGSYAVQWEMINYALNHGIDRYNFYGVSGKFTEDAEDAGVVKFKKGYNAEIIEYVGDFIKPINKPVYAAYTALKKVKDRIF
What is the function of this protein?
Catalyzes the formation of the pentaglycine interpeptide bridge, which is characteristic of the S. aureus peptidoglycan.  Adds glycines 2 and 3 of the pentaglycine bridge, using glycyl-tRNA(Gly) as donor.  Involved in resistance to methicillin (By similarity).
What are the official names of this protein?
Aminoacyltransferase FemA, Factor essential for expression of methicillin resistance A, N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase.
What is the protein family that this protein belongs to?
Belongs to the FemABX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL332_MYCBO
Sequence: MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLELKKFCPNCGKHQAHRETR
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: GDF8_HEMJE
Sequence: MQKLQIFVYIYLFMLLVAGPVDLNENSEQKENVEKKGLCNACLWRQNNKSSRLEAIKIQILSKLRLETAPNISKDAIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHVTTETVITMPTESDLLAEVQEKPKCCFFKFSSKIQHNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPEPGEEGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFLFLQKYPHTHLVHQANPKGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPGMVVDRCGCS
What is the function of this protein?
Acts specifically as a negative regulator of skeletal muscle growth.
What are the official names of this protein?
Growth/differentiation factor 8, GDF-8, Myostatin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECR_BACTN
Sequence: MNQQYPSVLLEKAVGEFSKLPGIGRKTAMRLVLHLLRQDTATVEAFGNSIITLKREVKYCKVCHNISDTETCQICANPQRDASTVCVVENIRDVMAVEATQQYRGLYHVLGGVISPMDGVGPSDLQIESLVQRVSEGGIKEVILALSTTMEGDTTNFYIYRKLEKMGVKLSVIARGISVGDELEYADEITLGRSIVNRTLFTGTV
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: PG023_MONPV
Sequence: MFDYLENEEVVLDELKQMLRDRDPNDTRNQFKNNALHAYLFNEHCNNVEVVKLLLDSGTNPLHKNWRQFTPIEEYTNSRHVKVNKDIAMALLEATGYSNINDFNIFSYMKSKNVDVDLIKVLVEHGFDLSVKCENHRSVIENYVMTDDPVPEIIDLFIENGCSVLYEDDEYGYVYDDYQPRNCGTVLHLYIIAHLYSESDTRAYVRPEVVKCLINHGIKPSSIDKNYCTALQYYIKSSHIDIDIVKLLMKGIDNTAYSYIDDLTCCTRGIMADYLNSDYRYNKDVDLDLVKLFLENGKPYGIMCSIVPLWRNDKETISLILKTMNSDVLQHILIEYMTFGDIDIPLVECMLEYGAVVNKEAIHRYFRNINIDSYTMKYLLKKEGGDAVNHLDDGEIPIGHLCESNYGCYNFYTYTYKKGLCDMSYVCPILSTINICLPYLKDINMIDKRGETLLHKAVRYNKQSLVSLLLESGSDVNIRSNNGYTCITIAINESRNIELLKMLLCHKPTLDCVIDSLSEVSNIVDNAYAIKQCIKYTMIIDDCTSSKIPESISQRYNDYIDLCNQELNEMKKIMVGGNTMFSLIFTEHGAKIIHRYANNPELRAYYESKQNKIYVEAYDIISDAIVKHNKIHKTIIKSVDDNTYISNLPYTIKYKIFEQQ
What is the function of this protein?
Substrate-specific adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins.  Prevents activation and subsequent nuclear localization of NF-kappa-B in infected cells, by targeting NF-kappa-B RELA subunit to the SCF E3 ligase complex.
What are the official names of this protein?
Ankyrin repeat domain-containing protein OPG023, Host range protein 1.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG023 family.
Protein: FBRL_MOUSE
Sequence: MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGRGGFGGGRGGFGGGGRGRGGGGGGFRGRGGGGGRGGGFQSGGNRGRGGGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:32017896).  Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity).  Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity).  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).  Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes (PubMed:32017896).  U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017896).  Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
What are the official names of this protein?
rRNA 2'-O-methyltransferase fibrillarin, Histone-glutamine methyltransferase, Nucleolar protein 1, U6 snRNA 2'-O-methyltransferase fibrillarin.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Fibrillar region of the nucleolus.
Protein: Y485_STAA1
Sequence: MDSHFVYIVKCSDGSLYTGYAKDVNARVEKHNRGQGAKYTKVRRPVHLVYQEMYETKSEALKREYEIKTYTRQKKLRLIKER
What are the official names of this protein?
UPF0213 protein SAHV_0485.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: KDGK_ECOLI
Sequence: MSKKIAVIGECMIELSEKGADVKRGFGGDTLNTSVYIARQVDPAALTVHYVTALGTDSFSQQMLDAWHGENVDTSLTQRMENRLPGLYYIETDSTGERTFYYWRNEAAAKFWLESEQSAAICEELANFDYLYLSGISLAILSPTSREKLLSLLRECRANGGKVIFDNNYRPRLWASKEETQQVYQQMLECTDIAFLTLDDEDALWGQQPVEDVIARTHNAGVKEVVVKRGADSCLVSIAGEGLVDVPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSAEDAAKRGHLTASTVIQYRGAIIPREAMPA
What is the function of this protein?
Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG).
What are the official names of this protein?
2-dehydro-3-deoxygluconokinase, 2-keto-3-deoxygluconokinase, 3-deoxy-2-oxo-D-gluconate kinase, KDG kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: ANGI_RHIBE
Sequence: MVMGLGLFLLVFMLGLGLTPPTLAQDNSRYRDFLTKHYDATPQGRNDRYCESMMRRRGLTSPCKDINTFIHGNSRHIKAICGDENGNPYGENLRISKSPFQVTTCNLRGGSSRPPCRYRATAGFRNIVVACENDLPVHLDQSIFRP
What is the function of this protein?
Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs).  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus.  Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA.  Angiogenin induces vascularization of normal and malignant tissues.  Angiogenic activity is regulated by interaction with RNH1 in vivo.
What are the official names of this protein?
Angiogenin, Ribonuclease 5, RNase 5.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: YSCQ_YERPS
Sequence: MSLLTLPQAKLSELSLRQRLSHYQQNYLWEEGKLELTVSEPPSSLNCILQLQWKGTHFTLYCFGNDLANWLTADLLGAPFFTLPKELQLALLERQTVFLPKLVCNDIATASLSVTQPLLSLRLSRDNAHISFWLTSAEALFALLPARPNSERIPLPILISLRWHKVYLTLDEVDSLRLGDVLLAPEGSGPNSPVLAYVGENPWGYFQLQSNKLEFIGMSHESDELNPEPLTDLNQLPVQVSFEVGRQILDWHTLTSLEPGSLIDLTTPVDGEVRLLANGRLLGHGRLVEIQGRLGVRIERLTEVTIS
What is the function of this protein?
Component of the Yop secretion machinery.
What are the official names of this protein?
Yop proteins translocation protein Q.
What is the protein family that this protein belongs to?
Belongs to the FliN/MopA/SpaO family.
Protein: PYRG_XANCB
Sequence: MTPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMMKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERYVRTRLSRKNSVTTGRIYENVIRKERRGDYLGATVQVIPHITDEIRRCIDEATAGFDVALIEIGGTVGDIESLPFLEAIRQVRTERGAEKAMFMHLTLVPYIAAAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQAVPDSERRKIALFTNVSERAVISCPDIDVLYGMPLELRRQGLDELVIDQFKLRDKVATADLSEWEAVVDAVKHPLDEVTIAVVGKYVDHQDAYKSVAEALKHGGLRQRTKVNLTWLEAQDLEGSDMAALQGIDGILVPGGFGDRGFEGKVQTSKYAREHKVPYFGICYGMQAAVVDYARHVADLDAANSTENDRQSPHPVIGLITEWRTATGEVEKRDEKSDLGGTMRLGLQEQRLKPGTLAREVYGKDVVAERHRHRYEFNNRYRTQLEDAGLVISGKSMDDTLVEMVELPRDTHPWFLACQAHPEFLSTPRDGHPLFIGFVRAAREKKAGGKLLKEARA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: NIFH_CHLPM
Sequence: MRKVAIYGKGGIGKSTTTQNTVAALAEMGKKVMVVGCDPKADSTRLLLGGLQQKTVLDTLREEGEEVELEDIIKGGYKNTRCTESGGPEPGVGCAGRGIITSVNLLEQLGAYDDEWELDYVFYDVLGDVVCGGFAMPIRDGKAEEIYIVCSGEMMAMYAANNICKGILKYADAGGVRLGGLICNSRQVENEKAMIEELARKIGTQMIHFVPRDNFVQRAEINRKTVIDYDPTHKQADEYRALAQKINDNKMFVIPKPLEIEELESLLIEFGIAN
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein, Nitrogenase Fe protein, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.