Protein: AT325_ASPTN
Sequence: MSSNEPIAIIGSSCRFAGGASSPSKLWDLLLKPKDLSKPPPESRFNLEGFYHPNAEQHGNTNIHGSYFLEEDPRCFDTVFFNISPKEAEAIDPQQRILLEVVYEAMEAAGLTLQGLQGSDTSVYAGLMIRDYMDVQVRDPDFFSQYMVTGTSSALNANRISYFFDWHGPSLTVDTACSSSLVAVHQAVQGLRAGESRVACVTGSNLLLGPELFISASNMHMLSSRSKMWDVSAEGYARGDGFASFMLKTLSNAIADGDHIEAIIRETGVNSDGRTKGITLPSPQAQADLIRDTYRRAGLDLSNPNDRCQYFEAHGTGTQAGDPREASAIHDAFFGAEGDDNKTGPKLVVGSIKTIVGHTEGTAGMAGMLKALLAIRHRVIPPNLHFNNLNPSVAPFYDRLTVPTESIPWPVVAPGTPLRASVNSFGFGGTNAHAIVESYEPDNRSSITGQNDGIVLPLVLSAHSDKALASVVENYAAFLRQTQQTLCLRDLAWTLHSRRSNLPVKAAFSGLSASDIAQQMQDRLESVRNTPGTELGIRSPAIASKKPSLLGVFTGQGAQWPTMGKHLIENSRTFRETIERLEKSLSELDDGPDWSLKGEILAQKAQSRVAEAALSQPLCTAIAIALVDLLHASGVSFTAVVGHSSGEIGAAYAAGVVTAEEAMKIAYYRGKYAKLAKGEHGAKGGMLAVGMGFNEAKEFCDQPAFKSRLGVAASNSPTSVTLSGDLDVVREAKELLDARKTFARMLQVDTAYHSHHMLPCADPYVSSLNASRIQPNEPAKSSCSWISSVYGSEGDPTAEELSATYWRDNMAQAVLFSQALERAMIECGPFDAVLEVGPHPALKGPASQTLRELSDGPLPYFGVLDRKRNDVVAFGDALASLWLHFGPSAVDFEGYAAASGPEDLPPPKLVKDLPAYPWDHSQIYWRESRLSREFRTRASPPHELLGHPLPAGSSEDGLRWRNILRIEEVPWIGDHRFQGQALLPTSAFCSMAVDAALKLAAGSVDPVADGIELHDLVIHNAVSIPDGSQGVEIITSIQRLEVTNHPLDAEVTVLFGPPDGSKVLKKAASARVILLHANSVDEPATLQAREKNLSSIDVPQFYQSIALVEGCIQTAYAAFSAPGDASLRPVFLPQKIERMSLRLPSVSSSDSWLIIDSFVTGVEKATPNTSPAFHADIEVADSVSGKLLVEIEGVTISSFSPTSAADDRELFLQTVWKPVVSEGLSVGNEQRKVANQAALDMEHQSILYLENLLANNLYLSGHLSQEFEWLLQLNLPSHSKGRQHNDGAEDVSHLDDFETLRAVAKNLPELIRGRLPGADIERQLQAFVETNSVFTRIKVGLHTLIDQIAHRFAHLNVLEIAPAHLSPSFDAFNDLVESISSYTLVTNSPSKDVAKYGKKLKHIGVEALHSDPSAIASALSGQKHDVVIASYLLNGQTASFSEEALRQFRKVLKAGGYLVLVEPTQEYVWSRIFLGVLLGSASNSDHGRDIGHHVSSVSLDGLLRKVGFSGIDSLLPRDANGPGDAISLFVTQALDETIDLLRHPLQPSALGILDGRRVLVVGGKTLQTSRLWHNIASILRPWTKEVHCIESFEALEEKDSTGIAGAIVLTDLDEPASKLLTTKSYQAISGLFAQAPHVLWVTQGALEANPEQAASIGLGHFLAQEHSSVHSQFLNLDTVEESEYKILGSFMRLLIPGIHDPQESRLWTTETEISVKNGRVFIPRVFPARGLNDRLNSHWRPIIQSANTLNDTTSLSASGSLHAATFTAQHFSSSSSAERRPILRTTQSIPIAINVSNGIYLYLSAGQVDDVGDVLAFTDTMSSRAPALATWKVPPAESGPVELSNILELTANVLVAQHIFDSLPAGNSVLLEPSYTLATIINELTKGADKKVHFLTTAAREETGSVTWTTIPPLASKRHILSALPPCPKLFFDLSPKPNRLSSRIVSLLPVDCALVGPGELFQLSSEGAEEVSTPWLQHVLLTVASSAVKLSRKATYPSSSTLILSDLLEHGIRNANAVTVVDWTQQTSVPVTVEPLEPSQFLSPAGTYVLIDIEQPLIQSIADWLIANGVRSLVAINSDIGERNGRELLDELKVKRLKVDLANLHDVKDVFDGLTKVTGVIYGGASAAMANFGEDDAPLQTLQNVEQSAHNLTTILENQEVGFFIILSSLQKDRAPVNAYFTSLAAHWKQRRLPTAVLSLESQVHSDPEGPFTHLSESDVHYALTEAISSAQSQNDVSAIWTGVKRLPRDIPASSQWSWLSKPLFAHYTQREQEAEPGSSQGEAQSMVQRLAASKSHEEASLVIQEFFLTRLAVMLTLSQESLSSSNDLTSLGVDSLSASDIRAWFLKELDVDVSILKILGGSTIADLCNEVAAGLTLQIGSQEEAESQPAVNSPEPVTAAPVPEQPTVERHVESQEPVVEAAVVASSSDSSSEGTMTPPSSRGINTPHTEITNLQLESVKSKACTAVQRREKMSFSQNRLWFPSAYLEQETPFNCTTSYTLTGPLDTARLENAFQRLIQRHESFRTAFYTDEVSGAAMQRVLASSPFQLRTMLGNKDDMQRVFRQIANYHFDLSVADTLVATLISHGPKDHTIVFGYHHIIMDGVSWQITLNDLARFYESDNPELPQLSQYIEFSVKQRQLVSSGAHDAKLSYWRKEFPSAPPLLPLFPFAKVGARKALTRYDTLDYIYDVDVSLVSKIKKASLAAKTTTFHFYLAAFVVLLNRFLEIDDVCLGIIDANRSDKTFLNTVGFLLDMLPLRLKVNKKERFVHTLRNTRAKAYNALEHSGVPLETILKELQVPTSATNTPLFQVLMNYRMGALRAPQMGDAKMNFLDYEDAKAPFDLAISIDEKDDGTGMLTFSMQDYMYDWEGAELLVKTYVHLLDTLATDSSQRINEVSLFDESLVNQSMVAGTGPVTGLDWAGTETISQRVDAMTAQRPDGVAVKDLNGKARTYAETQARVYALASSLQQAGITSGARVAVYCEPTVDTVALVLAIYRVGAAYIPLDVRNSHERLADVVRECKPTLILYHGATKHTLVDVAGDGQDALDIDTVPQSAAPIPDVSKLSDPAVILYTSGSTGKPKGIMLTHANLSLQFASISSALDLTDRDVVLQQSALGFDASLSQMFMALTNGGTLIHGSNRGDPVDLAALIEREGVTLTLIMISEMSALLQYGSDILSRCQSWRIALCGGEAFTVNLLRKFRDLNLPNLELYNAYGPTEASIMSSLGKVAYRRTDWGDGSVVPVGPPLPNYGVYVLDENFQPCPLGWPGELCICGPGVAEGYVGLPELTSSKFQPDQLRKPQGPSYDGWVRVYRTGDKARLLQDGSFVFLGRMDGDSQVKLRGIRIELNDISNSIVKTSKEAIVDAATIVKGTTSQTLVSFVVFAPAKVVDLERSNSSASAYLRQVIQSLPLPVYMRPAIAVPLERLPFTERGKLDTKALAAIPIQEDEETVNEELSETEQKLKQVWQDILSEQGMSLEIRRQSDFFSVGGNSLMLMRVRAKMLEVFGVSVPLAELFQASTLETLASRLDGNKTAESDNIVWNEETALDVSLPPAIAHPRDHPEKDLSVILTGSTGFLGRAIVRQLIADPRISTIHCLAVRPGRTLPEELVGSSKVIVYTGDLAAKRLGLSAPQAQEIFSSAAAIIHNGAEVSHMKSYHSLRPTNVDSTRQLVELALRSSIDSAVRTPAFHYVSTAGVGHLLGIPAFPEQSVSSSPPPVDGSDGYVAAKWASERILEQASERLGLPVFIHRPSNITGPDVGDRDIIHNVWRWSEVLRAVPDLVAAGAKGAFDFVGVETCAKGITDTLFVQASAGHLAYIHQSGENVIPVEEFGECLQRNGGADVELVPFDQWVDKAVQAGLDDLVASFLRGTKGAFQMPFLPKGLRQ
What is the function of this protein?
PKS-NRPS hybrid synthetase; part of the gene cluster that mediates the biosynthesis of isoflavipucine (PubMed:21236704).  The PKS part of the PKS-NRPS ATEG_00325 probably assembles a triketide from an acetyl starter and two malonyl-CoA extender units (PubMed:21236704).  The poly-beta-keto intermediate would then be fused to the leucine unit by the NRPS part (PubMed:21236704).  The resulting amide would be liberated from the PKS-NRPS through reductive release of the linear PKS-NRPS product from the enzyme complex (PubMed:21236704).  Further steps in isoflapucine synthesis include a cyclization step, an oxidation step, a hydrolysis step involving a trans-amidation, and an additional oxidation step, leading to flavipucine (PubMed:21236704).  Formation of isoflavipucine from flavipucine requires an unusual rearrangement (PubMed:21236704).  Alternative rearrangement reactions could build up rubrobramide, representing a branching of flavipucine biosynthesis (PubMed:21236704).  The enzymes involved in the post-PKS-NRPS steps have not been identified yet, but the putative oxygenases ATEG_003329 and ATEG_00330 encoded by the cluster could play a role (PubMed:21236704).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase ATEG_00325, Isoflavipucine biosynthesis cluster protein ATEG_00325.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.