PharMolix/UniProtQA huggingface dataset:
Protein: MDM10_PODAN
Sequence: MREFMQYVRNAFYGATGWSEDNSYKDLNVTARELIDFPLPRGIRLSLSSLATPHFATSYQLCNVGVVDGSISYLHSSVPLAAVPAQSNKIPLGALMRSYRGLHQLGSRGGTPWSWETGPQIGTIPQVPAVADMGQIPNKDKSSLLYGRLYLPQSLLEAMVIKRFSPALQVQISAVSEQSLRNGGTMLSVVQYDRGKYGVEGLYSTDGGLLGLRGLYNFGGDASVAVMSSQNGTGSPESTEKERIYGRFSAGGEMYYGTLNKSGGMSLGARFATLPTHKGTPLTATLTINPLMGNINTTYAVLAKDFLAMATRMEFNAYSYESDWAVGLELWSNRRPAGFLLGAEPSLDLESDQPELPSKKERSFQAKMEWRLDDPEPEPEPVKIAEKPTEGKEEYLGVFKARLSSNLDLGLVWEGRAKSLIFSLGTGVDLQRLGEPFRSLGLEVQYSS
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component MDM10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: Y2112_HALSA
Sequence: MSRSALIENVTAMLADAGFSVSDRCATRPKSFDVAARRGSDVVLMKVLVNIDAFDAETGAEMRRLGTYLHATPLVVGLRTRDEDLDPGVVYFRHGVPVFNPDTAMELFVDGIPPLVYAAPGGLYVNIDGDVLADRREDERLSLGQLASELGVSRRTVSKYEDGMNASIEVAMRLEDLFGGELTAPVDVMDGAEDVRDTDPTPDDPEAAPEDVPVLSVLARVGFEVHPTVQAPFKAVGEAGAGHDRLLTGHSAFTEAAVKRARIMSSVGEVTHTRAVYVVDEAGRESVDDTAIVEREELANVDDSEDLRDLLADRGDLQEA
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein VNG_2112C.
Protein: MUTY_AERHY
Sequence: MSNSDNTTFATRILDWYQIHGRKTLPWQQDKTPYRVWVSEIMLQQTQVATVIPYYQRFMARFPDVQALAQAPIDEVLHHWTGLGYYARARNLHKAAQQI
What is the function of this protein?
Adenine glycosylase active on G-A mispairs.  MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
What are the official names of this protein?
Adenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
Protein: MCM3Z_XENTR
Sequence: MAAPAVTELEDQEMREAQREYLDFLDDEEDQGIYQSKVRDMISENQYRLIVNVNDLRKKNEKRANMLMNNAFEGLIAFQRALKDFVASIDGTYAKQYEEFYIGLEGSFGNKHVTPRTLTSRCLSCIVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERKYTDLTSLEAFPSSAVYPTKDEENNPLETEYGLSIYKDHQTITIQEMPEKAPAGQLPRSVDIILDDDLVDKVKPGDRVQVIGTYRCLPSKQNGYTSASFRTILIACNVIQMSKEVTPVFSADDLAKIKKFSKSHSKDIFEQLSRSLAPSIHGHLYIKKAILCMLLGGVEKVLDNGTRIRGDINVLLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMDNIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAAGEQDGDAMPLGSAVDILATNDPNVTSEEQQELQVYEKHDSLLHGVKKRKEKILSVEFMRKYVHVAKIFKPVLTQEAASFIAEEYSRLRNQDQLSTDVARTSPVTARTLETLIRLSTAHAKVRMSKTVQLQDAEAAIELVQYAYFKKVLEKEKKRRRRDEDSDTEGEQQTQPDGEAKKRRKKRRAQEGESHDPYEFSDTEDETPVVHTPKTPVNGQEEMETDSSAKPGLSGERLKAFKSALLGAFKSAHAQSIAMEALMEAINKRNDSPFSQAEVKAALELMEEANHIMVSDNIVFLI
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development (By similarity).
What are the official names of this protein?
Zygotic DNA replication licensing factor mcm3, Zygotic minichromosome maintenance protein 3, zMCM3.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: PURA_SHEPW
Sequence: MGKNVVVLGTQWGDEGKGKIVDLLTEQAKYVVRYQGGHNAGHTLVIDGDKTVLHLIPSGILRDNVKCIIGNGVVLAPDALMTEINMLKERGVPVEERLLISEACPLILPFHCALDMAREKARGNKAIGTTGRGIGPAYEDKVSRRGLRVGDLFNAELFAEKLKEVMAYHNFMLTEYYKCEAVDYEETLKDALAIADYLKSMCTDVSELLDQARKAGEPILFEGAQGTLLDIDHGTYPFVTSSNTTAGGVATGSGFGPRHLDYVLGIMKAYTTRVGAGPFPTELENEIGDYLGTKGHEFGATTGRKRRPGWLDIVAMKRAVQINSVSGFCLTKLDVLDGLEEVKICVGYQYPDGTVATTTPLAAEGYEQVTPVLETMPGWSETTFGATSVEQLPQAAMNYIKRLEELLETPIDIISTGPDRNETMILVNPFS
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_PROMS
Sequence: MFEFEITSNCSNTAARTGIFHTPNGQVNTPKFMPVGTLATVKGISSKQLTSTGSEMILSNTFHLHLQPGEKLVKESGGIHKFMNWPKPILTDSGGYQVFSLAKLNNISDKGVEFKNPRDGSYVFLSPEKVIQIQMDLGSDVAMAFDHCPPHTANENDIEDSLQRTHSWLQKSVETHQKSNQALFGIVQGGKYPKLREYSAKYTSSFDLPGIAVGGVSVGETVEEIHSVINYVPKFLPIKKPRYLMGIGSLKEISLAVANGFDIFDCVLPTRLGRHGTAFFNDERLNLRNARFKNDFSPIDKTCKCETCKSYSRAYLHHLIRNDEILGLTLISLHNIAHLIRFTNAISTAIRDNCFTNDFAPWKTSSIAHHTW
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: Y1459_NITWN
Sequence: MITPAAYVGAAIAEIAGCFAFWAWLRLGKSVWWLVPGMASLALFAYLLTLVDSEAAGRAYAAYGGIYIMASLGWLWSVEGIEPDRWDLAGALICLIGAVVILIGPHEI
What are the official names of this protein?
UPF0060 membrane protein Nwi_1459.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSHA_STRBB
Sequence: MSQHVSRLGGLRGRSHGHGAFGGPYHQRLRRVGRRPRRIAMLSVHTSPLHQPGTGDAGGMNVYIVELAKRLAAIDIEVEIFTRATTGTLPPTVELAPGVLVRHVDAGPYEGLAKEDLPAQLCAFTHGVMGAWAGHRPGYYDLVHSHYWLSGHVGWLAAERWRVPLVHAMHTMAKVKNAALAEGDTPEPAARVIGEEQIVGAADRLIANTEEEADELVRHYGADPELVAVVHPGVNLERFRPADGRAAARARLGLPPDALIPLFAGRIQPLKAPDILLHAVAHLLDEDPRLRERIVVPVVGGPSGSGLAKPERLHKLAARLGVSDVIRFRPPCTQDELADWYRAASVLVMPSYNESFGLVAIEAQACGTPVIAAEVGGLPVAVRDGHSGILVPGHNPADYARELHRLSADPGLLKRLGSGAAHHAERFGWDKAAAATADVYAEAMRGYRRLRSVHG
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: S28A1_RABIT
Sequence: MEKASGRKSLALSTAENGIENAGLELTEEGINSEQTRRMEVQGHSLSDDVRPATHQRSYLQPLTKARTFCQRHASLFKKILLGLLCLAYAAYFLAACILDFQRALALFVITCLVILVLLLHFLKKFLGKKLTRCLKPFKNSQLRLWIKRVFAGVSLVGLILWLALDTAQRPEQLISFAGICMFVLILFACSKHHSAVSWRTVFWGLGLQFVFGLLVIRTDPGFIAFQWLGDQVQIFLAYTVAGSSFVLGDTLVNDVFAFQSLPIIIFFGCVMSILYYLGLVQWVVQKIAWFLQVTMRTTATETLAVAGNIFVGMTEAPLLIRPYLADLTLSEIHAVMTSGFATISGTVLGAFISFGIDASSLISASVMGAPCALALSKLVYPEEEESKFKSKEGVKLPRGKESNVLEAASNGATDAIALVANVAANLVAFLAVLAFINAALSWLGELVDIQGLTFQVICSYILRPMVYMMGVEWTDCPMVAEMVGIKFFTNEFVAYQQLSQYKKKRLSGMEEWIDGQKQWISVRAEVITTFSLCGFANLSSIGITLGGLTSMVPHRKSDLSKVVIRALFTGSCVSFISACVAGILYVPRGAETDCVSFLSTSFTNRSYETYVCCRELFQNTYLNGTNPPSFSGAWEDKAFSAMALANCCGFYNNTVCA
What is the function of this protein?
Sodium-dependent and pyrimidine-selective transporter (PubMed:11028933).  Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine) (PubMed:11028933).  Transports uridine, cytidine, thymidine, and nucleoside-derived drugs (By similarity).
What are the official names of this protein?
Sodium/nucleoside cotransporter 1, Concentrative nucleoside transporter 1, CNT 1, Na(+)/nucleoside cotransporter 1, Sodium-coupled nucleoside transporter 1, Solute carrier family 28 member 1.
What is the protein family that this protein belongs to?
Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEXA_STRM5
Sequence: MDLTDTQQAILQLIAERIESEGAPPSQTEIARAFGFKGVRAAQYHLEALEQAGAIRRIPGQARGIRLVQAPPLEKLAEPGLPDNVLRLPVLGRVAAGLPIGADIGSDDFVVLDRVFFSPAPDYLLKVQGDSMIDEGIFDGDLIGVHRTRDAHSGQIVVARIDDEITVKLLKIAKDRIRLLPRNPDYKPIEVLPDQDFSIEGLYCGLLRPNR
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: GLK_YERPS
Sequence: MTTYALVGDVGGTNARLALCAVATGEILQAKTYSGLEYESLEDVIKQYLSEHQAKVTDACIAIACPITGDWVAMTNHTWAFSIAAMQQNLGLDHLEVINDFTAVSMAIPVLPAQDVLQFGGTQPQPGKPVAVYGAGTGLGVAHLVNVDRRWISLAGEGGHVDFAPNSEEEDQILAVLRQELGHVSAERVLSGPGLVNLYRAIVISDARLPEKLAPKDITARALADSCTDCRRALSLFCVIMGRFGGNLALNLSTFGGVYIAGGIVPRFMEFFKASGFRAAFEDKGRFKDFLQDIPVYMITHPQPGLLGAGAYLRQKLGYELSS
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARTJ_CHLTR
Sequence: MCIKRKKTWIAFLAVVCSFCLTGCLKEGGDSNSEKFIVGTNATYPPFEFVDKRGEVVGFDIDLAREISNKLGKTLDVREFSFDALILNLKQHRIDAVITGMSITPSRLKEILMIPYYGEEIKHLVLVFKGENKHPLPLTQYRSVAVQTGTYQEAYLQSLSEVHIRSFDSTLEVLMEVMHGKSPVAVLEPSIAQVVLKDFPALSTATIDLPEDQWVLGYGIGVASDRPALALKIEAAVQEIRKEGVLAELEQKWGLNN
What is the function of this protein?
Probably part of an ABC transporter complex involved in arginine transport.  Binds arginine (By similarity).  Interacts with host epithelial cells, suggesting a role in host-cell adhesion during infection.
What are the official names of this protein?
Probable ABC transporter arginine-binding protein ArtJ.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Secreted. Cell surface.
Protein: RL24_CAMJJ
Sequence: MAVKLKIKKGDSVKVITGDDKGKTGKVLAVYPKTLKVVVEGCKIAKKAIKPSEKNPNGGFINKEMPMDISNVAKVQE
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: FABZ_ANASK
Sequence: MSETAERKPILDVVGIQKLLPHRPPFLLVDRVVEFEPNKRVVALKGVTMNEPFFQGHFPAQPVMPGVLILEALAQAAALLATLSMKPEEVNDKITYLMGIDAARFRRPVVPGDRLELEVEVTKQKGAVWKQTGVARVDGQVVAEAEFMAMLADRER
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRIB3_MOUSE
Sequence: MRATPLAASADVSCRKKPLEFDDNIDAKCPVLKRVRDEPEPGPLPSLLPPSPPPASDLSPAVAPATRLGPYILLEREQGSCSYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLGSRLLYIFFTKTHGDLHSLVRSRRGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWDKHACPAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRYPFHDSEPVLLFGKIRRGTFALPEGLSAPARCLIRCLLRKEPSERLVALGILLHPWLREDHGRVSPPQSDRREMDQVVPDGPQLEEAEEGEVGLYG
What is the function of this protein?
Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:17369260).  Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (By similarity).  May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity).  Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (PubMed:12749859, PubMed:17369260).  Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (PubMed:12791994).  May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (PubMed:12791994).  Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (By similarity).  Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity).  Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230).
What are the official names of this protein?
Tribbles homolog 3, TRB-3, Neuronal cell death-inducible putative kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRC_LATSS
Sequence: MYRLIQNGQLLIDDQLVKRDIAIDEKGRITAIEAQITPTDEPTETIFDAQGALVSAGLIDGHVHFRDPGFTDKETLQTGSQAAAHGGYTSVIAMPNLNPVPDNLSDFKTLVARNQTETSVHTYQFAPITGDLVNNDLVDMPAFKAAGAAGFTNDGHGVQDAQTMYLAMQQAAAIDAPIVAHVEDISLVNGGVIHDGAAAKRLNVPGIPSVSESAQVARDIELARATGVHYHICHISTKETVALVRRAKADGVNITCEVTPHHLLLDDRSIISDDTMLKMNPPLRTLADRQSLWAGLMDGTIDVIATDHAPHTAAEKSQSLLQAPFGIVGSETAFSLLYTHLVVNGPFSLAQLLAKMTTVPAQVFNLPAAGQLRVGDQADIAVFNLTQPTTIQATDFQSKGHNTPFIGETVLGGTELTLVAGQVAYQRSK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: T2M7_METJA
Sequence: MRKMFICLHNTYSAKQVEEFGRIAYGFDINTIVVTKATASAAQSGIPTLHKMAYKLGKNVLFFEELDDAIEVLRPEKVFLIGNKSICDEKVDFNEVGENDLVVFCGASTGFTKLELEKGLGRYIVENEIGALGNLAIFLYEMSKKI
What is the function of this protein?
A putative type II restriction enzyme, its methylase would be M. MjaORF1200P (AC Q58600).
What are the official names of this protein?
Putative type II restriction enzyme MjaORF1200P, R.MjaORF1200P.
What is the protein family that this protein belongs to?
To A.pernix APE2001.
Protein: TAD2B_DANRE
Sequence: MADLGKKYCVNCLADVTNLRIRCAECQDIELCPECFSAGAEIGNHRRWHGYQQVDGGRFSLWGPEAEGGWTSREEQSLLDAIEQYGFGNWEDMAAHVGASRTPQEVMDHYVSMYIHGNLGKACIPDSIPNRVTDHTCPSGGPLSPSLTTPLPPLDITVVEQQQLGYMPLRDDYEIEYDQEAEKLISGLSVNYDDEDIEIEMKRAHVDMYVRKLRERQRRKNIARDYNLVPAFLGRDKKDKERERAGGTVGVGGPGGAVGSGSGATVVPAGPLGSSTAATPKRKITKEEKGQRTKLRALCQFMPQREFEEFFDNMHKERMLRAKVRELQRYRRNGITRLDESAEYEAARHKREKRKENKSIAGSKRGSSGGGGGTAGLGGGVGAGGGLGGGGGVSTIKEEGKDSEFSAIENLSGFELLSDREKVLCNSMNLSPMRYLTVKTIIIKDHLQKRQGIPSKSRLPSYLDKVLKKRILNFLSESGWISRDAS
What is the function of this protein?
Transcriptional coactivator.
What are the official names of this protein?
Transcriptional adapter 2-beta.
What are the subcellular locations of this protein?
Nucleus.
Protein: SC16B_RAT
Sequence: MELWVPQTQGRTTGPSRDANRRLQSGHYRPRPHPQYSGDNYHQWQDTHKNSKPQQDPRDDHQQPHYVPRSGEWSQPVSGADYLKGSYPSHPYSRSGYEDPYQSYHTPTPRDEYAYGNYYYHGHPQLPQGERVARQGSPYIWHEDHRDQRHFSEHHWEKHNSTFEANSDTQFQFTSKNPYNDNPASAFGLEQPGEFFPESGAQKQKPSLTSKSNLLQQHESGLSSSSYELSQYMTEAPEQYEPMVSATWRPIQADDTSATVPKAPMRFYVPHVSVSFGPGGQLICVSPNSPADGQTALVEVHSMEVILNDFEDQEEMRAFPGPLIREDIHKVDIMTFCQKKAAQCLKSETPGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLSSGTRNLLTGEIPLNVDTPAQIVEKFTNLLYYGRKKEALEWAMKNHLWGHALFLASKMDPRTYNWVMSGFTTTLALNDPLQTLFQLMSGRIPQAATCCGDKQWGDWRPHLAVILSNQAGDAELYQRAIVSMGDTLAGKGLVEASHFCYLMAHVPFGHYTVKTDHLALVGSNHSQEFLKFATIEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLASQALHYCEAIGAAVLSEGGSSHPVLLAELIKLAEKLKLSDPLVLESRRGDRVLEPDWLVQLRRKHKELEQTRTGDLRDPDLTPSDIYGARGTTDTPYRDLYGQQNYSEDSEYSSALWPTSEQTSLTNPTPQQPFPLQRDTYSERDGPVHMGTPVPLYSVPATHLTVISGSSSGSGVAVTGAPGGRVGEEMLQKHPALGENTVPQEAVQDPDGLAVISSPQTPLAPRDRSFSEDSAISAKEDEEGTSDGADKPPHPDASQKEKLRDGKNTKSSGFGWFSWFRSKPASSVSTSGDEDSVDSSDSEESPRASPPHHASLGLSPTPPLSSPSLPGASTFPRGTGGNSLQGSSNSSGMAEGVGIGGFSGPQGVSSEFYSQPGALPPPPTLQGAVPLYNPSQVPQLPTASSLNRPNRLAQRRYPSQPC
What is the function of this protein?
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).  Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.  Involved in peroxisome biogenesis.  Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes.
What are the official names of this protein?
Protein transport protein Sec16B, Leucine zipper transcription regulator 2, Regucalcin gene promoter region-related protein p117, RGPR-p117, SEC16 homolog B.
What is the protein family that this protein belongs to?
Belongs to the SEC16 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).
Protein: TP1C_HADIN
Sequence: QECIAKWKSCAGRKLDCCEGLECWKRRWGHEVCVPITQKIFCLEKWKSCFERKYDCCEELECWERRGNKHPVCAPKQ
What is the function of this protein?
This toxin potently and selectively inhibits ASIC1a, an isoform of the gene ASIC1.  It incompletely inhibits ASIC1a activation in a pH-independent and slowly reversible manner.  This toxin acts by binding to and stabilizing the closed state of the channel, thereby impeding the transition into a conducting state.  This toxin may bind to the acidic pocket of ASIC1a, since mutation of a key residue of this pocket (Arg-350) abolishes the ability of the toxin to inhibit ASIC1a.  In vivo, this toxin protects the brain from neuronal injury when administered up to 8 hours after stroke onset.
What are the official names of this protein?
Pi-hexatoxin-Hi1c, Pi-HXTX-Hi1c, Double-knot toxin, DkTx.
What is the protein family that this protein belongs to?
Belongs to the psalmotoxin-1 family. Double-knot toxin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYV_CAEEL
Sequence: MSDPAGNRPKTEKELKKEAEKAAKLAKFEEKQKKLAEKKAAASDKPVKEAKAKKEQTVEAAEPVDQTPTGQRKKIDGEIPAAYFPGYVESGWYSWWEKEGFFKPEYIDKLNPGSNPADSFTVCIPPPNVTGNLHVGHALATTVEDTITRFNRMHGKRTLFNPGCDHAGIATQVVVEKRLKRERGLTRHDLGRDRFNQEVWHWKNEKGDVIYDQFRKLGASVDWDRAVFTMDPKMCRAVTEAFIRMHESGTIYRSNRLVNWSCALRSAISDIEVDKKELTGSTLIAVPGYDKKIEFGVLNSFAYKIQGSDEEIVVSTTRIETMLGDSGVAVHPDDQRYKHLVGKQCIHPFIPTRNLPIFADSFVEMEFGTGAVKITPAHDHNDYEVGIRQNLPFHNCITDDGLISQGCGEFSGMKRFDARTAVIEALKEKGLYRGKEDNPMVVPTCSRSKDVIEPILKPQWYVKCAHMAEKAVAAVANGDLQIIPEFHKATWNRWLESSRDWCISRQLWWGHRIPAYYISFADGREQPLPEENYWVSARTEQEALAKAAQKFQVPEAEILLKWDEDVLDTWFSSGMWPFAVFGWPDATKDMDLFFPGAVLETGHDILFFWVARMVFMAQELTGKLPFKEILLHAMIRDAHGRKMSKSLGNVIDPLDVIRGISLNDLQAQLLGGNLDEKEIAVAKEGQARDYPDGIPECGVDALRFALLSYTSQGRDINLDVLRVHGYRKFCNKLWQVVRFALARISDKPEQKPTFEINLKSATPTDLWILSRLAKAVKETNEALKAYNFTQATTVTYNFWLYDFCDVYVETIKPVLYGDNTTLRQVAISVLHKCIDTGLRLISPLMPFISEELWQRMPRLDDSDYTSPSIIVAQYPLTQKYEKYQNEKLEAAFEFAQELIGKVRSLRADYDLKKTKITMQILSETPEDESMLNDISAVITTLTFSEKVSILNKCESDKIEKGSAHIACGGRCQVYINLTGIIDVPKEIEKLGAKLQKNQISVKKIGDIQSSADYEQKVPVDIRALDQEKKATLEKEIENITAAIAQLKALN
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein: OMCB_CHLFF
Sequence: MSKLIRRVVTVLALTSMASSFASGKTEVAAAESLVTRFIASAEASDSNILQTTAKKIRFGRNKNQKPEQKNNNAFCDKEFYPCEGGQCQSSVDTRQESCYGKMYSVRVNDDCNVEISQAVPEYATVGSPYPIEILAVGKKDCVNVVITQQLPCEVEFVSSDPVTTPTSDSKLIWTIDRLGQGERCKITVWVKPLKEGCCFTAATVCACPELRSYTKCGQPAICIKQEGPECACLRCPVCYKIEVCNTGSAIARSVVVDNPVPDGYTHASGQRVLSFNLGDMRPGDSKCFTVEFCPQKRGKVTNVATVSYCGGHKCSANVTTVINEPCVQVNISGADWSYVCKPVEYTIVVSNPGDLKLYDVVIEDTAPSGASILEAAGAEICCNKAVWCIKEMCPGETLQFKVVAKAQTPGKFTNQVVVKTNSDCGTCTSCAEVTTHWKGLAATHMCVIDTNDPICVGENTVYRICVTNRGSAEDTNVSLILKFSKELQPVSSSGPTKGTITGNTVVFDALPKLGSKESVEFSVTLKGVAPGDARGEAILSSDTLTVPVADTENTHVY
What is the function of this protein?
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin.  It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan.  It is present but the disulfide bonds are reduced in reticulate bodies (RBs) (By similarity).
What are the official names of this protein?
Large cysteine-rich periplasmic protein OmcB, Large-CRP, 60 kDa CRP, 60 kDa outer membrane protein, Cysteine-rich outer membrane protein.
What are the subcellular locations of this protein?
Periplasm.
Protein: CISY_RICAK
Sequence: DSEFAELKIRGKIFQLPILKASIGEDVIDISRVSAEVNCFTYDPGFMSTASCKSTITYIDGDKGILRHRGYNIKDLAEKSDFLEVAYLLIYGELPSIEQYNNFTKQVAHHSLVNERLHYLFQTFCSSSHPMAIMLAAIGSLSAFYPDLLNFKEADYELTAIRMIAKIPTIAAMSYKYSIGQPFVYPDNSLDFTENFLHMMFATPCTKYKVNPIIKNALNKIFILHADHEQNASTSTVRIAGSSGANAFACISTGIASLWGPAHGGANEAVINMLKEIGSSENIPKYIAKAKDKSDPFRLMGFGHRVYKNYDPRASVLKETCKEVLKELGQLENNPLLQIAIELEAIALKDEYFIERKLYPNVDFYSGIIYKAMGIPSQMFTVLFAIARTVGWMAQWKEMHEDPGQKISRPR
What are the official names of this protein?
Citrate synthase.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.