PharMolix/UniProtQA huggingface dataset:
Protein: NUOH2_RHIEC
Sequence: MNKWPRIMELIVAFGLIVFKVALLIAILLLLPLPLTWLERKIAGHMQQRMGPMRVGWHGLLQPVADGIKLLTKEDHIPAEADRFLFKLAPILALAPPFVVFVAIPFGETISVRGTEITLYLSNMNVALLFVFAVIGIEVFGVIFGGWAANSKYAVLGSLRTCAQMISYEIPMGFAVIGVVMLAQSMSLLDIVRAQTDVWNIVYQPVGFFVFFVAGLAEAQRIPFDLAEAEGDLGAGFHTEYSGIRFAFFMVSEYVIVLLVSVLLVILFFGGWNGILVPMPPLLWFLLKVAFFVYLFIWFRFTFPRYRYDQLMAIGWKVLLPLSMANIIITGVLLGAAAAP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H 2, NADH dehydrogenase I subunit H 2, NDH-1 subunit H 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: P3F4A_XENLA
Sequence: MATAASNPYSILSSSSLVHADSAVMQQGSPFRNPQKLLQSDYLQGVPCNGHPLGHHWVTSLSDANPWSSSLASSPLDQQDIKPGREDLQLGAIIHHRSPHVNHHSPHTNHPNAWGASPAHNSSLTSSGQPINIYSQPSFTVSGMLDHGELTPPLPAGTTQSLHPVLREPNDHVDLGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGNPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPKPAALEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDPQQHEVYSHSVKTDTSCNEL
What is the function of this protein?
Transcriptional activator.  Induces neural-specific gene expression to act as a key regulator of neural differentiation.
What are the official names of this protein?
POU domain, class 3, transcription factor 4-A, Transcription factor POU2, XlPOU 2, XlPOU2.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: KDM4A_HUMAN
Sequence: MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELPPRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTGVLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDINLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
What is the function of this protein?
Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter.  Lacks the N-terminal demethylase domain.
What are the official names of this protein?
Lysine-specific demethylase 4A, JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, [histone H3]-trimethyl-L-lysine(36) demethylase 4A, [histone H3]-trimethyl-L-lysine(9) demethylase 4A.
What is the protein family that this protein belongs to?
Belongs to the JHDM3 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNT_SALCH
Sequence: MSDNAQLSGLCDRFRGFYPVVIDVETAGFNAKTDALLEIAAITLKMDEQGWLMPDTTLHFHVEPFAGANLQPEALAFNGIDPSNPLRGAVSEYEALHAIFKMVRKGIKDSGCSRAIMVAHNATFDHSFMMAAAERASLKRNPFHPFVTFDTAALSGLALGQTVLSKACLAAGMEFDGEKAHSALYDTERTAVLFCEIVNRWKRLGGWPLPLPTDK
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: SECA_BRUME
Sequence: MVSFGGLARKIFGSSNDRRVKTLRQRAEQITALEKNYENLTDEQLQAKTAEFRAALAEGKSLDSLLPDAFATAREAAKRVLGMRPFDVQLIGGMVLHERGIAEMRTGEGKTLMATLPVYLNALEGKGVHVVTVNDYLATRDAETMGRLYNFLGLTVGVIKHGLDDDERRAAYACDITYGTNNELGFDYLRDNMKYERAQMVQRPHNYAIVDEVDSILIDEARTPLIISGPLEDRSDFYNLIDTFIPPLAEEDYEVDEKQKTAIFTEVGTEKVEKLLEAAGHLKGESLYDIENVAVVHHLNNALRAHKLFQRDKDYIVRNDEIVIIDEFTGRMMPGRRYSEGLHQALEAKEHVTIQPENQTLASITFQNYFRMYNKLSGMTGTAATEAEEFGNIYGLEVLEIPTNLPVQRIDEDDEVYRTVEEKYRAIVRDIRASHEKGQPILVGTTSIEKSEQLAERLRREGIKGFQVLNARYHEQEAYIIAQAGVPGAVTIATNMAGRGTDIQLGGNLEMRVRQELSDVPEGPEREEKIAAIKADIAQLKEKALAAGGLYVLATERHESRRIDNQLRGRSGRQGDPGRSKFFLSLQDDLMRIFGSDRMDGMLQKLGLKEDEAIVHPWINKALEKAQKKVEARNFEIRKNLLKYDDVMNDQRKVIFEQRLEMMDEEDLTETVAEMRHEVIEDMVILRIPKDAYAEKWDIAGLKQDIASKLNLDLPVEEWAKEEGIAEEEFENRIKEAADKAAAEKAERFGPQIMTYVEKSVIMQSLDNLWREHLVNLDHLRSVVGFRGYAQRDPLNEYKTEAFELFQTMLANLREVVISQLMRVEIVREAPPEPQLPPMAGLHIDGATGENDFDEAIWAEHQHDDRIVPPAQRDPADPRTWGKVSRNEPCPCGSGKKYKHCHGAFE
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: MCC31_ARATH
Sequence: MSLDLKMQDKFTWVLEKFSSLKDQCYSPVFTVAGCNWRLLSFLKGAKNDRYFSVYLDLEPGSLPPGWRREVKFSITLDNVCPNTDRVLGGPCFFDAKSNIWGFQDFLLLEKLVNIAEGFLVNDRLTIVAEVDVLPSITRLHLVLEDASRGRDPNTVACVTETCDYVLMEIQSDKETVDINGFVVVSSKAESVRRILERHPDISVEFRGKNQQLRNACMNFLLSLIETMCQSLEELSNEDLVEADVALTYLRDAGFKVDWLEKKLDQLKEKKEEEMSGLARLHEIEERLQKLKLLFVDLESQLQKEKVEALVARAPLSFNDGVCRFSGFCGFVGESLFSYAWKQGPSLYSLSFMSNGTE
What are the official names of this protein?
MATH domain and coiled-coil domain-containing protein At3g58440, RTM3-like protein At3g58440.
Protein: CAB45_DANRE
Sequence: MFNWRRSQLSCLCASTLAVFVMLALNVQGRPANISALKGKQPNSKEDNEILPPDHLNGVKMEMDGHLNKDFHQEVFLGKEMEEFEEDSEPRRNRKKLIEIFTKVDINKDRSVSAKEMQRWIMEKTEEHFQEAVRENKLSFRAVDPDGDGLVTWDEYRVKFLASKGLNEKEVAEKIKNNEELKVDEETQEVLESLKDRWFQADNPPADQLLNEEEFLSFLHPEHSRGMLRYMVKEIVRDLDQDGDGKLTLAEFISLPMGTVENQQAQDIDDDWVRERKKEFEEVIDANHDTIVTMEELEEYMDPMNEHNALNEAKQMIAVADENQNHNLELEEILKYSEYFTGSKLMDYARNVHEEF
What is the function of this protein?
May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
What are the official names of this protein?
45 kDa calcium-binding protein, Cab45, Stromal cell-derived factor 4, SDF-4.
What is the protein family that this protein belongs to?
Belongs to the CREC family.
What are the subcellular locations of this protein?
Golgi apparatus lumen.
Protein: ATPF_SOLLC
Sequence: MKNVTDSFVSLGHWPSAGSFGFNTDILATNPINLSVVLGVLIFFGKGVLSDLLDNRKQRILNTIRNSEELRGGAIEQLEKARSRLRKVETEAEQFRVNGYSEIEREKLNLINSTYKTLEQLENYKNETIQFEQQRAINQVRQRVFQQALRGALGTLNSCLNNELHLRTISANIGMLGTMKEITD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: VPK24_HUMAN
Sequence: WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKIPFEAKINQKREGIGYPF
What is the function of this protein?
Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle.  Endogenous Pro proteins may have kept, lost or modified their original function during evolution.  This endogenous protein has retained most of the characteristics of retroviral proteases.
What are the official names of this protein?
Endogenous retrovirus group K member 24 Pro protein, HERV-K101 envelope protein, HERV-K_22q11.21 provirus ancestral Pro protein, Protease, Proteinase, PR.
What is the protein family that this protein belongs to?
Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.
Protein: RTP_BACSH
Sequence: MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSEFKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQLKVELDRCKKLIEKALSDNF
What is the function of this protein?
Plays a role in DNA replication and termination (fork arrest mechanism).  Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site.  The binding of each dimer is centered on an 8 bp direct repeat (By similarity).
What are the official names of this protein?
Replication termination protein, Replication terminator protein.
Protein: CP136_MYCTO
Sequence: MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLPGVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLRARELLENYFTARVKERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR
What are the official names of this protein?
Putative cytochrome P450 136.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: TIM9_CANAL
Sequence: MDQLNVKEQQEFQQIVEQKQMKDFMNLYSNLVSRCFDDCVNDFTSNSLTSKETSCIAKCSEKFLKHSERVGQRFQEQNALLMQQGPK
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM9.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: INS_ICTTR
Sequence: MALWTRLLPLLALLALLGPDPAQAFVNQHLCGSHLVEALYLVCGERGFFYTPKSRREVEEQQGGQVELGGGPGAGLPQPLALEMALQKRGIVEQCCTSICSLYQLENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KN14G_ORYSJ
Sequence: MPIVGNAGAGSVGAKPGSWLPEWKRIVVLLGSWTLGVRENEKGSGSRLIKWNGSGSREQKICKTTLPLFQACIKHLNSRDLLSTKVLTLALYKYILRAPQTAPHPPAAPPRTEVASSTAGRASRTKSASSTGRVSRANPASFHRPRLLRQAGLHLRRPRLSRQAGLRCHRLHLSAPSRSPTPPPNAVAPSSCSRLPRARLAIRGRRASSHSATVDTACSRRHSCDCLNRHRHLAVVATSAVAATTVAVPTACLCCGQIPLGRHRHNQAVTGRDLTVAALVLLAEVARETTGYSNGAPDPAAVVAISCCRPGSIPPSTAAAGSCRRHPAAVTARWPLAGGARSGRRDNPRRQGTGATRTGISKTYVSSVVAKTLALQELKGNIRVFCRVRPLLPNESGAVAYPKSGENLGRGIELTHNGQMYFFTFDKVFEQSTSQEDVFIEISHLVQSALDGYKVCIFAYGQTGSGKTYTMMGNPELHDQKGLIPRSLEQIFQTSQALISQGWKYKMQASMLEIYNEAICDLLATNHTTIQDGGASKYSIKHDANGNTHVSDLIIVDVLSINEVSSLLKRAAQSRSVGRTQMNEESSRSHCVFTLRFFGVNEGTDQQVQGVLNLIDLAGSERLNKSGATGDRLKETQAINKSLSCLSDVIFSIAKKEEHVPFRNSKLTYLLQPCLGGDSKTLMFVNLSPEVSSTGESICSLRFAARVNSCEIGIPRRQTQVRSLAQG
What are the official names of this protein?
Kinesin-like protein KIN-14G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.
Protein: RIMO_COLP3
Sequence: MIAEQHQAVVDSGASKKGAKVGFVSLGCPKNLVDSERILTQLRTEGYDVTNSYDDAELVIVNTCGFIDSAVQESLDTIGEALAANGKVLVTGCLGVKKDEIIELHPNVLGVTGPHAYDEVLAQVHEHVAKPEHNPFIDLVPPQGVKLTPKHYAYLKISEGCNHRCTFCIIPSMRGDLDSRPVGDVLGEAKRLVDSGVKELLVISQDTSAYGVDVKHKTDFWDGMPVKTHMQQLCEELAKQGVWIRLHYVYPYPHVDKIIPLMAEGKILPYLDIPFQHANKRILKLMKRPGSSDRVLERIAKWREICPELVIRSTFIVGFPGETEEEFEELLNFLEEAQLDRVGCFKYSPVEGATANALPDHVSDEVMEDRLQRFMAVQAKISSDKLQVRIGQEYLILVDEVNGLGIVGRSYMDAPEVDGKVYLSDDYDAKPGDQIWVQIIHADEHDVWGVRVED
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIL_CAUVC
Sequence: MAPSTRSPVMHETDEEDWFAEDDAAAPAAAPPTEFDHIARLLRPLTRGDPVALDLLDDAAVLPSRPGYDLVITKDAMVAGVHFLAEEALDVVARKLLRTNLSDLAAKAAEPYGYFLAVGWPSGSDVASRETFARGLAEDGALFDISLLGGDTVTTSGPLVVSATFLGWAPQGETILRRGAKPGDRLMVSGTIGDGWLGLLAQWGEVMDADGAMLRRYRQPEPRVTLRDAMRVHAKAAADVSDGLLADSSHIAKASGCRVRVDLERLPLSPGAQAWLDQQPEQVEGRISLASGGDDYEIVCAVDPNEAWAFRVAAAAAGVKVSEIGEFVEGEGVSAYYKGRDVTPSRLGWLHG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
What are the official names of this protein?
Thiamine-monophosphate kinase, TMP kinase, Thiamine-phosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-monophosphate kinase family.
Protein: RL19_HELP2
Sequence: MKNRYIQQFEDAQLKDKTMPIFKAGDTLKLGITIKEGEKTRTQYFEGVCIAIRGNGVDKTFCVRKIGANNIGVEKIFPFYSESLASVEVLRVGRVRRAKLYYLRDRRGKAARIKEVRH
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: PRM6_YEAST
Sequence: MESSLQKLKFQDIDINLIPTAKWTTKLQYILYTWCQSILHVAMFFSDIYTCIKLLAFNTWSNNIIQPFLEFRISKWLFSGCILCSSLILIWELVIGLRVYRKKEITSNYMNGISRLINCLFNFKKYQIFELIVLTDEKKFSKWLFFSYFEISGCLRLLFGDSPRQIINGLTLWSVLLTVSNETSSGTHSTQSLGNLDDLNGIINKIKHIAKTNYEESVILSFMLFSFIIWVILISKLILSIIIFIIFIRPRFLSSKRKVKGYELKLRKYVSKVIDENLSRTVYELGILIDDEEEGTICGDNKTQKKFDYDSPDYGDESTIPSYYCYSDVETYERVYTPIKAYFPQKYKHKYI
What is the function of this protein?
Low affinity potassium transporter that, with KCH1, participates in high-affinity Ca(2+) influx system (HACS) activation during the response to mating pheromone (PubMed:21252230, PubMed:23204190).  Directly promotes K(+) influx and HACS may electrochemically respond to this K(+) influx (PubMed:23204190).  KCH1 and PRM6/KCH2 act at the apex of the calcium signaling pathway that is used for survival during prolonged exposures to mating pheromones (PubMed:23204190).
What are the official names of this protein?
Pheromone-regulated membrane protein 6, Low affinity K(+) transporter 2.
What is the protein family that this protein belongs to?
Belongs to the KCH1 low affinity K(+) transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bud tip. Vacuole lumen. Note=Localizes to the distal tip of growing buds.
Protein: RL18_OREMO
Sequence: MGVDIRHNKDRKVHRKEPKSQDIYLRLLVKLYRFLARRSNAPFNRVVLRRLFMSRTNRPPIAVSRLIRKMKLPGRENKIAVVVGTVTDDVRIQDIPKLKICALRVTDGARRRILKAGGQVMTFDQLALASPKGQGTVLLSGPRKAREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASCGYKN
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL18 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: SEM7A_MOUSE
Sequence: MTPPPPGRAAPSAPRARVLSLPARFGLPLRLRLLLVFWVAAASAQGHSRSGPRISAVWKGQDHVDFSQPEPHTVLFHEPGSFSVWVGGRGKVYHFNFPEGKNASVRTVNIGSTKGSCQDKQDCGNYITLLERRGNGLLVCGTNARKPSCWNLVNDSVVMSLGEMKGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNRNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDRVFRTSSLKGYHMGLPNPRPGMCLPKKQPIPTETFQVADSHPEVAQRVEPMGPLKTPLFHSKYHYQKVVVHRMQASNGETFHVLYLTTDRGTIHKVVESGDQDHSFVFNIMEIQPFHRAAAIQAISLDADRRKLYVTSQWEVSQVPLDMCEVYSGGCHGCLMSRDPYCGWDQDRCVSIYSSQRSVLQSINPAEPHRECPNPKPDEAPLQKVSLARNSRYYLTCPMESRHATYLWRHEENVEQSCEPGHQSPSCILFIENLTARQYGHYRCEAQEGSYLREAQHWELLPEDRALAEQLMGHARALAASFWLGVLPTLILGLLVH
What is the function of this protein?
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses.  Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3.  Promotes production of pro-inflammatory cytokines by monocytes and macrophages.  Plays an important role in modulating inflammation and T-cell-mediated immune responses.  Promotes axon growth in the embryonic olfactory bulb.  Promotes attachment, spreading and dendrite outgrowth in melanocytes.
What are the official names of this protein?
Semaphorin-7A, Semaphorin-K1, Sema K1, Semaphorin-L, Sema L.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Protein: HYPB_HELPJ
Sequence: MSEQRKESLQNNPNLSKKDIKIVEKILSKNDIKAAEMKERYLKEGLYVLNFMSSPGSGKTTMLENLADFKDFKFCVVEGDLQTNRDADRLRKKGVSAHQITTGEACHLEASMIEGAFDLLKDEGALEKSDFLIIENVGNLVCPSSYNLGAAMNIVLLSVPEGDDKVLKYPTMFMCADAVIISKADMIEVFNFRVSQVKEDMQKLKPEAPIFLMSSKDPKSLEDFKNFLLEKKRENYQSTHSF
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.  Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion.
What are the official names of this protein?
Hydrogenase/urease maturation factor HypB.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.
Protein: AAEB_SHIBS
Sequence: MGIFSIANQHIRFAVKLATAIVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGFLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRIENSYAWGLAGYTALIIVITIQPEPLLTPQFAVERCSEIVIGIVCAIIADLLFSPRSIKQEVDRELESLLVAQYQLMQLCIKHGDGEVVDKAWGDLVRRTTGLQGMRSNLNMESSRWARANRRLKAINTLSLTLITQSCETYLIQNTRPELITDTFREFFDTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWVAAATRYQLLKRGVISNTKINATEEEILQGEPEVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCISLAVLGFFLGIEVQQRLLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAVSAMTTNVARRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSAFHRQMRRTADHVISARSDDKRRRYFGQLLEELEIYQEKLRIWQAPPQVTEPVHRLAGMLHKYQHALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: F16P2_RAT
Sequence: MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLANLYGIAGSVNVTGDEVKKLDVLSNSLVINMLQSSYSTCVLVSEENKEAVITAKERRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTTEDEPSEKDALQPGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDIRIKKKGKIFSLNEGYAKYFDAATAEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFMYPANQKSPNGKLRLLYECNPVAYIIEQAGGMATTGTQPVLDVKPESIHQRVPLILGSPEDVQEYLSCVQRNQAGR
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.
What are the official names of this protein?
Fructose-1,6-bisphosphatase isozyme 2, FBPase 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase 2, Muscle FBPase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cell junction. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration. In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase. Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration.
Protein: MTTB_METBU
Sequence: MTNENLCAGRNRYDGVSIDFFSDADLRAIDSATMDVFQNPGIQVSDAESRALFKEAGCDVNEKTMVVKIPEHVVRRAIMTAPSKITLYGREKQHTFTQQAGGKVHYTCFGTGVKMCKYEAPGVFKTVDSTEEDLANTARVCDWADNIDSYSLAVSARDWAGKGAQDVHETFTPLMNTSKHFFHIDPVGENVEYYWDILKAYYGGDEEQARSRPIFSELLCPTSPLKIGTNACQLILKSVNFGIPINVISMAMSGASCPVHLAGTLVTHNAEVLSGIVLAQLASPGAKVWYGSSTTAFDLKHGTAPVGSPELGLISAAVAKLGQYYDLPTYVASTOTDAKVPDGQAGHEKTLTNLLPALAGANTLYGAGMLELGMTFSMEQLMIDNDIISMGKKVMKGIPVNDETLGLASIQKVGIGNNFLAHKETRDNINLVSSPDIFDRDMFGDWAAAGSKDIATVAHEKVTEILKNHEVTPIDSDLVRDMKAVVDRADADFRSSM
What is the function of this protein?
Catalyzes the transfer of a methyl group from trimethylamine to the corrinoid cofactor of MttC.
What are the official names of this protein?
Trimethylamine methyltransferase MttB, TMA methyltransferase, Trimethylamine--corrinoid protein methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the trimethylamine methyltransferase family.