PharMolix/UniProtQA huggingface dataset:
Protein: ADF1_PETHY
Sequence: MANAASGMAVHDDCKLRFLELKAKRTHRFIVYKIEEKQKQVVVEKIGEPTESYEDFAASLPENECRYAVYDFDFVTAENCQKSRIFFIAWCPDTARVRSKMIYASSKDRFKRELDGIQVELQACDPTEMGLDVIQSRAN
What is the function of this protein?
Actin-depolymerizing protein.  Severs actin filaments (F-actin) and binds to actin monomers (By similarity).
What are the official names of this protein?
Actin-depolymerizing factor 1, ADF-1.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
Protein: CPS4L_HUMAN
Sequence: MQEVIAGLERFTFAFEKDVEMQKGTGLLPFQGMDKSASAVCNFFTKGLCEKGKLCPFRHDRGEKMVVCKHWLRGLCKKGDHCKFLHQYDLTRMPECYFYSKFGDCSNKECSFLHVKPAFKSQDCPWYDQGFCKDGPLCKYRHVPRIMCLNYLVGFCPEGPKCQFAQKIREFKLLPGSKI
What are the official names of this protein?
Putative cleavage and polyadenylation specificity factor subunit 4-like protein.
What is the protein family that this protein belongs to?
Belongs to the CPSF4/YTH1 family.
Protein: CSRA_SHEB5
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQSEKSGTPSEGGNF
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POP1_HUMAN
Sequence: MSNAKERKHAKKMRNQPTNVTLSSGFVADRGVKHHSGGEKPFQAQKQEPHPGTSRQRQTRVNPHSLPDPEVNEQSSSKGMFRKKGGWKAGPEGTSQEIPKYITASTFAQARAAEISAMLKAVTQKSSNSLVFQTLPRHMRRRAMSHNVKRLPRRLQEIAQKEAEKAVHQKKEHSKNKCHKARRCHMNRTLEFNRRQKKNIWLETHIWHAKRFHMVKKWGYCLGERPTVKSHRACYRAMTNRCLLQDLSYYCCLELKGKEEEILKALSGMCNIDTGLTFAAVHCLSGKRQGSLVLYRVNKYPREMLGPVTFIWKSQRTPGDPSESRQLWIWLHPTLKQDILEEIKAACQCVEPIKSAVCIADPLPTPSQEKSQTELPDEKIGKKRKRKDDGENAKPIKKIIGDGTRDPCLPYSWISPTTGIIISDLTMEMNRFRLIGPLSHSILTEAIKAASVHTVGEDTEETPHRWWIETCKKPDSVSLHCRQEAIFELLGGITSPAEIPAGTILGLTVGDPRINLPQKKSKALPNPEKCQDNEKVRQLLLEGVPVECTHSFIWNQDICKSVTENKISDQDLNRMRSELLVPGSQLILGPHESKIPILLIQQPGKVTGEDRLGWGSGWDVLLPKGWGMAFWIPFIYRGVRVGGLKESAVHSQYKRSPNVPGDFPDCPAGMLFAEEQAKNLLEKYKRRPPAKRPNYVKLGTLAPFCCPWEQLTQDWESRVQAYEEPSVASSPNGKESDLRRSEVPCAPMPKKTHQPSDEVGTSIEHPREAEEVMDAGCQESAGPERITDQEASENHVAATGSHLCVLRSRKLLKQLSAWCGPSSEDSRGGRRAPGRGQQGLTREACLSILGHFPRALVWVSLSLLSKGSPEPHTMICVPAKEDFLQLHEDWHYCGPQESKHSDPFRSKILKQKEKKKREKRQKPGRASSDGPAGEEPVAGQEALTLGLWSGPLPRVTLHCSRTLLGFVTQGDFSMAVGCGEALGFVSLTGLLDMLSSQPAAQRGLVLLRPPASLQYRFARIAIEV
What is the function of this protein?
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:8918471, PubMed:30454648).  Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).
What are the official names of this protein?
Ribonucleases P/MRP protein subunit POP1, hPOP1.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MUTB_STRVG
Sequence: MRIPEFDDIELGAGGGPSGSAEQWRAAVKESVGKSESDLLWETPEGIAVKPLYTGADVEGLDFLETYPGVAPYLRGPYPTMYVNQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDHPRVTGDVGMAGVAIDSIYDMRQLFDGIPLDKMTVSMTMNGAVLPVLALYIVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDIFAYTSQKMPRYNSISISGYHIQEAGATADLELAYTLADGVEYLRAGQEAGLDVDAFAPRLSFFWAIGMNFFMEVAKLRAARLLWAKLVKQFDPKNAKSLSLRTHSQTSGWSLTAQDVFNNVTRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLIQQESGTTRTIDPWGGSAYVEKLTYDLARRAWQHIEEVEAAGGMAQAIDAGIPKLRVEEAAARTQARIDSGRQPVIGVNKYRVDTDEQIDVLKVDNSSVRAQQIEKLRRLREERDDAACQDALRALTAAAERGPGQGLEGNLLALAVDAARAKATVGEISDALESVYGRHAGQIRTISGVYRTEAGQSPSVERTRALVDAFDEAEGRRPRILVAKMGQDGHDRGQKVIASAFADLGFDVDVGPLFQTPAEVARQAVEADVHIVGVSSLAAGHLTLVPALREELAAEGRDDIMIVVGGVIPPQDVEALHEAGATAVFPPGTVIPDAAHDLVKRLAADLGHEL
What is the function of this protein?
Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.  This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthesis.  It is unable to catalyze the conversion of isobutyryl-CoA into N-butyryl-CoA.
What are the official names of this protein?
Methylmalonyl-CoA mutase large subunit, MCM-alpha.
What is the protein family that this protein belongs to?
Belongs to the methylmalonyl-CoA mutase family.
Protein: MURG_AROAE
Sequence: MKTLLVMAGGTGGHIFPGVAVAEQLRGRGWRIVWMGNPDGMEARIVPQHGYETAWVHFGALRGKGLLRKLLLPLNLLRGFWQALGELRRIRPDVVLGMGGYVTFPGGMMAALLGRPLVVHEQNSVAGLANRVLAGVADRVLSGFPHTLKKAGWVGNPVRADIAAVAPPDARFAGRSGPLKLLVVGGSLGAAVLNDTVPKALARIDKAQRPIVTHQAGAKQLEALRAAYAEAGVEGELLPFIDDMASRYAEADLVVCRAGALTVAELAAVGAASLLVPFPHAVDDHQTGNAQFLADRGAAYLLPQPQLDAERLAGIIESLARDHLLDMATKARALAKPRAAEAVAQVCEELAAGRKKK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYY_CERS1
Sequence: MTYHPKSDFLRVMQERGYLADCTDMQALDEALSNGVVPAYIGYDATAASLHVGHLLNIMMLRWLQKTGHKPITLMGGGTTKVGDPSFRSEERPLLTPDRIDENIEGMRKVFARYLSYGEGATDALMLNNAEWLDQLNYLDFLRDIGRHFSVNRMLSFESVKSRLDREQSLSFLEFNYMILQAYDFLELFRRTGCRLQMGGSDQWGNIVNGIDLTRRVLEGEIFGLTSPLLTTSDGRKMGKSAGGAVWLNGEMLAPYDFWQFWRNTTDADVGRFLKLYTELPVEECDRLGALQGSEINAAKILLANEVTTLLHGRDAAEAAEATARAVFEEGGVGGALEVVELPAATLGDGLSVAHFLVAAGLVASGKEAKRLVAENGLRFNNEPVGDANAPVTAATVGEELKVSIGRKKHKLVRLS
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACDH_ECOSE
Sequence: MSKRKVAIIGSGNIGTDLMIKILRHGQHLEMAVMVGIDPQSDGLARARRMGVATTHEGVIGLMNMPEFADIDIVFDATSAGAHVKNDAALREAKPDIRLIDLTPAAIGPYCVPVVNLEANVDQLNVNMVTCGGQATIPMVAAVSRVARVHYAEIIASIASKSAGPGTRANIDEFTETTSRAIEVVGGAAKGKAIIVLNPAEPPLMMRDTVYVLSDEASQDDIEASINEMAEAVQAYVPGYRLKQRVQFEVIPQDKPVNLPGVGQFSGLKTAVWLEVEGAAHYLPAYAGNLDIMTSSALATAEKMAQSLARKAGEAA
What is the function of this protein?
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A.  Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: RL10E_SULIN
Sequence: MPLRPGRCYRHFSGPAYTRKEYIPGIPQPKITKFTSGNPNGDYDYEVRLITTEIGQIRHNALEAVRTITLKTLTKRTGSETSFFMWILKYPHHVLRENKMMAFAGADRLQDGMRLSFGTPIGTAARIEKLGEILIVVKVKKEHLDFAKEALKIASKKLPLRTRIEIIPLRPIRQEVQS
What are the official names of this protein?
50S ribosomal protein L10e.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RS8_BIFAA
Sequence: MTMTDPIADMLTRLRNASAAKHETVDMPYSKFKANIAEILKREGYIKDFTAKEAKVGQTLEVTLKYGPNGERSIQGIKRISKPGLRRYAKSDALPMPLGGLGIAIISTSSGLLTQKECLDRGIGGEIVAFVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: P2_RTBVP
Sequence: MSADYPTFKEALEKFKNLESDTAGKDKFNWVFTLENIKSAADVNLASKGLVQLYALQEIDKKINNLTTQVSKLPTTSGSSSAGAIVPAGSNTQGQYKAPPKKGIKRKYPA
What are the official names of this protein?
Protein P2, ORF 2, P12.
Protein: PA22_ACAPL
Sequence: MKTFLILAMAVALAKAQSTDEITNLVQFGKLVMCLGNIGYTEGLEYDGYGCFCGKGGKGTPVDATDRCCEVHDNCYGQAVEEGKCWSVETYGTTYWYDQSTSGSCSIRCWEEGDYNSLVPRKACKAAICECDRKAAQCFADNRPTFNRKYLNYAKDTC
What is the function of this protein?
Starfish phospholipase A2 (PLA2) that has hemorrhagic and capillary permeability-increasing activities and hence is considered to be deeply involved in the local inflammation.  Shows hemolytic activity only in the presence of phosphatidylcholine (PC).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 AP-PLA2-II, PLA2, Phosphatidylcholine 2-acylhydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: OBG_ENDTX
Sequence: MFIDKVNTYLAAGRGGDGCISFRREKYVPYGGPDGGNGGNGGDIYFESDQHKTTLLDLSYRPKFKAEDGQKGSSGDKSGRYGEDLIIKIPLGTLIFKNGEFFADLKTVGERILIVKGGRGGRGNASFKTGRHTVPRIAEKGAPGETAEVNLELRLIADVGLLGLPNAGKSTLLSQISAAKPKIADYPFTTLAPNLGVVNYKGKHFTAADIPGIIEGAYKGIGLGFEFLRHIRRTKVLIHVIDVNGFDGRDPYENYKIINNELKKYSKHLAKKHVIIVLNKIDSAVSLEQIKNFKKHLKVKKLFETSAATGYGIDALLKEMLRMLEKPVAFSTEGEVEPLHVKKYIYEPEFKISIENGIFVATGAKVETLTEVTKFNEDESLRRYRNILKKMGLEIELKKMGARPGDTVRIGDFEFTFEK
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_THET2
Sequence: MFKEVGEPNFPKLEEEVLAFWKREKIFQKSVENRKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPVELEVEKKLGLKSKREIEAYGIERFNQACRESVFTYEKEWEAFTERIAYWVDLENAYATLEPTYIESIWWSLKNLFDRGLLYRDHKVVPYCPRCGTPLSSHEVALGYKEIQDPSVYVRFPLKEPKKLGLEKASLLIWTTTPWTLPGNVAAAVHPEYTYAAFQVGDEALILEEGLGRKLLGEGTPVLKTFPGKALEGLPYTPPYPQALEKGYFVVLADYVSQEDGTGIVHQAPAFGAEDLETARVYGLPLLKTVDEEGKLLVEPFKGLYFREANRAILRDLRGRGLLFKEESYLHSYPHCWRCSTPLMYYATESWFIKNTLFKDELIRKNQEIHWVPPHIKEGRYGEWLKNLVDWALSRNRYWGTPLPIWVCQACGKEEAIGSFQELRERATQPLPEPFDPHRPYVDQVELACECGGTMRRVPYVIDVWYDSGAMPFASLHYPFEHQETFRESFPADFIAEGIDQTRGWFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIREFGADALRWYIYVSAPPEADRRFGPNLVRETVRDYFLTLWNVYSFFVTYANLDRPDLKNPPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVEDLSQWYVRRNRRRFWKNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRSVRPEAKESVHLADWPEADPALADEALVAQMRAVLKVVDLARAARAKSGVKTRTPLPLLLVTAPTALEREGLKRFAHEIAEELNVKEVRVLEPGEEILSYRVLPNLKLLGRKYGKLVPKIREALQRERERAAALALKGEAIPLEVEGEALTLLPEEVLLEAEAPKGYQALEKDGYVAALKVEVTEALRMEGLARDLIRLLQQARKDMGLKVSDRIRVGYEAEGPYLEALKRHGPWIAEEVLATAFGEGLFGGFEARVEDEEGKAVFHLARAE
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_PYRFU
Sequence: MGFRYKQVIVARSDLKLSKGKLAVQVAHGAVTAAFEAYKKKREWFEAWFREGQKKVVVKAQNEEELFKLKSEAEKLGLPTALIRDAGLTEIPPGTITVLAIGPGPEEVVDKVTGHLKLL
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MECA_STRP2
Sequence: MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKIDQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFAKLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLNLQKIG
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: Y3845_MYCS2
Sequence: MSETVVVRVKPGSRKGPLVETADDGTLTIYVQERAVDGKANAAVTKLLAAHLGVPPSRVELASGATARLKRFRIS
What are the official names of this protein?
UPF0235 protein MSMEG_3845.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: ERN1_MEDTR
Sequence: MEIQFQQPNMQNQKAGISVTNKGGKFKGRNRNSNNTNKFVGVRQRPSGRWVAEIKDTTQKIRMWLGTFETAEEAARAYDEAACLLRGSNTRTNFITHVSLDSPLASRIRNLLNNRKGDKKQEDGAVASAPSNSKTTISNTSTITSNDDNKESTLSTCATRNTELFEDAYKPDLSNCKEVFESGSQSNISCGFGPFFDHFSFTQLLDMAKNDDITDASSLELSEFERMKVERQISASLYAINGVHEYMETVQESNEALWDLPPLCSLFC
What is the function of this protein?
Transcription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs) (PubMed:17449807, PubMed:17827349).  Binds to the GCC-box (NF-responsive box) of ENOD11 promoter.  Acts as transcriptional activator of NF-responsive box-containing target gene promoters in root hairs (PubMed:17827349).  Functions as a transcriptional regulator required for root infection by symbiotic rhizobia, infection thread (IT) formation and maintenance, and nodule development.  Necessary for NF-induced gene expression and spontaneous nodulation activated by CCAMK.  Functions downstream of CCAMK to activate nodulation gene expression (PubMed:17449807).  Involved in early stages of root nodule development.  Functions redundantly with ERN2.  Is essential with ERN2 for the initiation of root hair infection, and nodule organogenesis and development.  Required for accurate expression of the NF signaling genes ENOD11 and ENOD12 (PubMed:23077241, PubMed:27208242).
What are the official names of this protein?
Ethylene-responsive transcription factor ERN1, ERF transcription factor ERN1, NF box-binding protein 1, Protein ERF REQUIRED FOR NODULATION 1.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSB4_MOUSE
Sequence: MEAFWESRAGHWAGGPAPGQFYRIPATPSGLMDPASAPCEGPITRTQNPMVTGTSVLGVKFDGGVVIAADMLGSYGSLARFRNISRIMRVNDSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARELVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSAQTNWDIAHMISGFE
What is the function of this protein?
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).  SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
What are the official names of this protein?
Proteasome subunit beta type-4, Low molecular mass protein 3, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain, Proteasome chain 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: COXZ_RICFE
Sequence: MSKKSNKNLAFSLLGLIISMVLLSFASVPIYNLFCKVTGYGGTTAKETVSVYSKVKGTKPIIIEFDANVDKDLPWRFIPRQQRVQIVPGQNTLVFYETENLSNNDIIGTSVYNVTPNKAGKYFVKIHCFCFEEQLLKADEKVLMPVTFYIDKDFELDPEMQDIKVLTLSYSFFKVREIASLRGNTKY
What is the function of this protein?
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
What are the official names of this protein?
Cytochrome c oxidase assembly protein CtaG.
What is the protein family that this protein belongs to?
Belongs to the COX11/CtaG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: SLD5_YEAST
Sequence: MDINIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDFSDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPNESKLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEIKYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKWNEDPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI
What is the function of this protein?
Required for DNA replication.  Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery.
What are the official names of this protein?
DNA replication complex GINS protein SLD5.
What is the protein family that this protein belongs to?
Belongs to the GINS4/SLD5 family.
Protein: FTSH2_PHYMT
Sequence: MKKNIKDIFKNFNIFWFCFIFLLLSLLYCLIMMEISHQHDNNKPSEIIAVLKEIKELQTKSTEESKKESKESKESKEDKTKIIKIKKFDIHETSNYGSYLIVFQWGTGNKDSFEWEKELKFPNVDQETYKEIMKICFEIIGTPIDKKDNITNLSQMITKIKEKTNLIPLQRIPYQPYFGFAPFISAVNICILIIIFYFIYNSIEKTSAQISGKNLNISRQKVLVNQQEFTFKDIAGADEEKEEMSELINFLKNPFKYEAMGARIPKGVLLYGPPGVGKTLLAKAVAGEAKVPFFAVSGSDFIEVYVGLGASRIRKLFNEAKQNAPCIIFIDEIETISHQRGSVNYSNSEHDQTLNQLLVEMDGFTKNIGVIVMAATNQPESLDLAVTRPGRFDRHFHITLPSVKDREAILKLHARNKKFNDDVDFESLAKQTPGFNGAQLEAILNESALLATRRNVLVICNEDISEALDRVLMGPSKKSKKYNDKEKRMVAYHESGHAVIGLKLPEADQIQKVTIIPRGNAGGYNLTLPQEETFFSSKKRLLAQITSFLGGRAAEEVVFQDVSNGAYSDFKYATEIAKKMVTQYGMSDLGPIQYMENNFYKNFSDSKAVEIDKEIQKIIDYCYQNAKKIITENRDLLDLISKYLLEIETITQKDLEEILNTGIIEWWEKDKLKKNLQKSEKEDCNK
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: MTND1_VITVI
Sequence: MAIEQAWFMEENDEDQRLPHHRNPKQFVSLDHLADLGVLYWKLNPKDYENDQELKEIRESRGYNYMDLLDLCPERVENYEEKLKNFYTEHIHGDEEIRYCLEGSGYFDVRDKEDRWIRIWIKEGDMIVLPAGIYHRFTLDTGNYVKLMRLFVGEPVWTAYNRPQEHHPARKNYINNVTHKVGVPLEAH
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase 1, Acireductone dioxygenase (Fe(2+)-requiring) 1, ARD' 1, Fe-ARD 1, Acireductone dioxygenase (Ni(2+)-requiring) 1, ARD 1, Ni-ARD 1.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ADC_ACICJ
Sequence: MDAATIRETAFAMPLTSPGFPKGPYRFVNREYMIITYRTDRAALEKIVPEPLELADDVVKYEFIRMPDSTGFGDYTESGQVIPVRYKGKPGVYVHSMFLNDHPPIAGGREIWGFPKKLARPVLEVEIDTLVGTLDYGRIRVATGTMGYKHHTLDHDPVLSSMHEPNFLLKIIPHVDGSPRICELVRYHMSDIVLKGAWTGPAALALYPHALAPVADLPVREVVAASHILADMTLDLGEVVHDYLA
What is the function of this protein?
Catalyzes the conversion of acetoacetate to acetone and carbon dioxide.
What are the official names of this protein?
Acetoacetate decarboxylase, AAD, ADC.
What is the protein family that this protein belongs to?
Belongs to the ADC family.
Protein: UREE_KLEP7
Sequence: MLYLTQRLEIPSAATASVTLPIDVRVKSRVKVTLNDGREAGLLLPRGLLLRGGDVLSNEEGTEFVQVIAADEGVSVVRCDDPFMLAKACYHLGNRHVPLQIMPGELRYHHDHVLDDMLRQFGLTVTFGQLPFEPEAGAYASESHGHHHAHHDHHAHSH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURF6_DROME
Sequence: MTQAEIVKCLREEYEIEHNKDQKPEKEDLPAITKKFYQRVLELLTIHKVPYSKQEDEETYEEYLLSDTEESGNKKKKQQGKLKNQDSDDEDVEARIASIKNKLRQKKGPTTERQQKRRESKKLKRSKGVQKLLLSSAKNLKNENVKHQKLKNGVVKSEQETEDSKEQIQPVKVQPVYNQEAKIVYSKVDFAANPGGKAKKSHQNPKEILKKLRDTKKHLTELREQGETDKAAEIQTDIAWRNAFDKVEGKKVKDDTKLLQKAIKKRRVEKKKSKTKWTERKQKVEHDKEKRQKKRQENLEKRSKDKKNRKLKTASKRGRIIPGY
What is the function of this protein?
Involved in a nucleolar function.
What are the official names of this protein?
Surfeit locus protein 6 homolog.
What is the protein family that this protein belongs to?
Belongs to the SURF6 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.