Protein: PKS24_BYSSP
Sequence: MRVTSRVYLFGDQTGEFETGLRQLLQAKNNSLLTSFFERCFYALRQEVSKLPPSQRQIFPRFTSIVDLLARHREFGPNPALESALTCIYHFACFINHYGDGGHAYPSASESHIIGLCTGLLASAAVSSSRTVGELIPAAIETVTVSLRLGLCVLRTRDLIDRSYEKSQSWSMVVSGLNEEEVGALIHGFCQRKSISPSSRPYISAVNTHSLTISAPPTILQEFTNVCLSKENRPVRVPVHAPYHAPHLYDRRDVTSILESWPKGELANYTPRIPVLSSETGEIILARNLHELLGIALEEILLRKLCWDKVQDGYASMLKRTSSAACRIFPIASAASHGLSAALKRTGVPDVEVDNTISESAKTCDNENSTGRTEQSKIAIIGLSGRFPDAPSPEHFWDLLYKGLDVHRVVPPDRWDVKAHVDPTGKIRNTSKVPYGCWIEEPGLFDPRFFNMSPREALQADPAQRLALVTAYEALEQAGFVPDSTPSTQKDRVGIFYGMTSDDYREVNSGQDIDTYFIPGGNRAFTPGRINYHFKFSGPSVSVDTACSSSLAAIHLACNSLWRNDCDTAIAGGTNVLTNPDNFAGLDRGHFLSAKGNCNTFDDEADGYCRADAVGTVVLKRLEDAQADKDPILGVILGAYTNHSAEAVSMTRPHVGAQAFIFNKLLNEANVSPRDVGYIEMHGTGTQAGDAVEMKSVLDIFAPDYTRGPSQSLYLGSAKANIGHAESASGVSSLIKVLLMLKANTIPPHCGIKTKINHNFPTDFKERNVHIAFKPTSWERPQDGKRRLFVNNFSAAGGNTALLIEDAPLSTVSGAPDSRSTHIVAVSARSQSSLRNNIRSLMKYVSELDGQIGGENFLGKLSYTTTARRIHHQFRTMVSGSSLKGIQEALSSAASRDSFTPIPASTPSIGFVFTGQGAQYTGMGQQLYSSCSQFRDNIDRFDSIARSQGFPSIVPLIDGSVPVEEMSPVVTQLGTTCLQMAMTRYWMSLGVKPAFVLGHSLGNYAALNAAGVLTTSDTIYLSGRRAQLLQEKCQVGTHSMLAIKANLAQIKPFLDDDAYEVACINAPGETVISGLSANIDVLSEKLTAEGLKSTKLRVPYAFHSAQVEPILESLGEVAQGVTFHKPSIPVVSALLGEVINEDNWDALGPRYLQRHCRETVNLLAALEATRHAKLMNEKTIWIEVGSHPICSGMIKGTLGPQANTVASLRRNEDTWKVLCNSLSAIYLAGVDIQWKEYHGDFTSSHQVLQLPAYSWDNKNYYIPYNNNFCLTKGDPTVAKIEAAPTSQFHTTSVQRIVETRDEGSKAVVVMESDLSDPLLNPVIQGHKVNGAALCPSSLYADIAQTLGEYLIENYNPALRGSGLDVCDMTVPKPLIAKNSGPQLFRAMATADWEERKANIQIYSVKSDGKKIMDHASCLVKFSDTHLWEADWKRHSYLIKRSIERLQKSVEEGQSHRMHRGMFYKLFSALVDYGDNYKSVEEVVLDSEEYEATARVKFQAKSGNFHRNPFWIDSIGHLTGFVMNANDATDSQSQVYVNHGWDFMRCLKKFSPDTTYRTYVKMQPWQGTIYAGDVYAFDGDEIVAVYGGVKFQGVPRQVLNTVLPPAGGSKAAPRTTARAVPPPPINVEKPKSSVEAKAVSKAVPGDPVKSAGPSVLVQALKILAEEIGVSEAELSDDLVFADYGVDSLLSLTITGKFREELNMDLESSTFIDHPTVKDLKQLLSQASPSDSSDSSEESHYSFRDSSSTEPSTPGTPAFFSPKRGSVVTNVGESETIKTIRLTLSEEIGVSPDEITGDANLAEMGMDSLLSLTVLGRLRETLDIELPSDFFIENPTMDAVETALDLKPKAEPIPSELPVPIQTAAGDEINGVIKANSTHPPATSILLQGNPKKATKTLFLFPDGSGSATSYATLPAVSSDVCVYGLNCPYMKNPENLKCGLDELTMPYVAEIRRRQPKGPYSFGGWSAGGICAYDAARYLILEEGEKVERLLLLDSPFPIGLEKLPPRLYSFFNTIGLFGEGKTPPPKWLLPHFLAFIDSLDAYNAVPFPFSDPELGENMPKTYLIWAKDGVCGKPGDPRPDPPTDGSKDPREMLWLLNDRTDMGPNGWDTLVGPNNVAAIEAIEGADHFTMMKGDKAAKLSAFIGRAMAS
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster 24 that mediates the biosynthesis of a pigment with an aromatic structure protecting the pigmented fungus from both ionizing and non-ionizing radiations based on a mechanism similar to melanin, that is, free radical quenching and spherical spatial arrangement (PubMed:33989788).  Catalyzes the biosynthesis of the gamma-naphthopyrone precursor YWA1, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:33989788).  YWA1 is probably further processed by the additionnal enzymes present within the cluster 24, however these additionnal steps have not been characterized yet (Probable).  YWA1 is not converted to DHN-melanin in Byssochlamys spectabilis since the use of the DHN-melanin pathway inhibitor pyroquilon does not result in a loss of pigmentation (PubMed:33989788).
What are the official names of this protein?
Non-reducing polyketide synthase PvBS090_009107, Pigment biosynthesis cluster 24 polyketide synthase.