PharMolix/UniProtQA huggingface dataset:
Protein: ACT4_DROME
Sequence: MCDEEASALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDCYVGDEAQSKRGILSLKYPIEHGIITNWDDMEKVWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRTPEALFQPSFLGMESCGIHETVYQSIMKCDVDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF
What is the function of this protein?
Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
What are the official names of this protein?
Actin, larval muscle, Actin-79B.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: LEUC_SHEPW
Sequence: MAKTLYEKVWDAHIVVAAEGEAPIIYVDRHLVHEVTSPQAFSGLEVAGRKMRAPEKTFATMDHNTSTTSASLDALSPMARTQVQTLERNCKEFGVRLYDIHHKNQGIVHVMGPELGITLPGTVIVCGDSHTATHGAFGALAFGIGTSEVEHVMATQTLRQLKAKTMKIEVRGHVAEGITAKDIVLAIIGKIGMDGGTGYVVEFCGEAIEALTMEGRMTVCNMAIEMGAKAGMIAPDATTAEYLKGREFAPKGDNWQQAIAAWAELKSDADATFDATVVLQASDIAPQLTWGTNPGQVVAIDQFVPNPAEETNSTVRSSIEKALEYVDLSAGTLMTNVGINKVFIGSCTNSRIEDLRAAAVHAKGRQVAEGVKAIVVPGSGLVKEQAEAEGLDKIFLEAGFEWRLPGCSMCLAMNDDKLEAGDRCASTSNRNFEGRQGRGSRTHLVSPAMAAAAAVAGHFVDIRKPY
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: TRMB_STAEQ
Sequence: MRVRYKPWAEDYLKNHPDLVDMDGAHAGKMSEWFEKEQPIYIEIGSGMGQFITTLAAQYPEINFVSMEREKSVMYKVLDKTKEMGLKNLKMICNDAIELNEYFKDKEISRIYLNFSDPWPKKRHAKRRLTYHTYLALYKQILKDDGEIHFKTDNRGLFAFSIESMSQFGMYFTKMNLNLHDEDDEDNIVTEYEKKFSEKGSRIYRMEAKFHKCFE
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: DCEA_ECOL6
Sequence: MDQKLLTDFRSELLDSRFGAKAISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT
What is the function of this protein?
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction.  The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions.  The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity).
What are the official names of this protein?
Glutamate decarboxylase alpha, GAD-alpha.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: Y1322_SHEPC
Sequence: MLGWTLMFLVVAIIAGLFGFTGIAGAAAGIAKIIFFLFIVLLVISLLVNAIKGRAPRP
What are the official names of this protein?
UPF0391 membrane protein Sputcn32_1322.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDXH_BURA4
Sequence: MTTLADLRINYSRASLDEADVAPDPFAQFDRWFKEALAAKLPEPNTMTLATVGENGRPSARIVLIKGVDERGFVFFTNYESRKGRDLAAHPYAALLFYWIELERQVRIEGRIEKTSTDESDRYFASRPLGSRIGAWASEQSAVIDSRATLEAREKAVAERYGENPPRPPQWGGYRVVPDAIEFWQGRPSRLHDRLLYTRDAAAAPGWTISRLSP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: Y481_CAUVC
Sequence: MPVRPVLKIVKGQPTSDGAGVRLTRMLGTPEAQMFDPFLMLDCFDNDQASDYLGGFPDHPHRGFETVTYMLEGRMRHKDNTGREGVIGPGGIQWMRAGKGIVHSEMPEQDQGRMRGFQLWVNLPARLKMSAPGYQEFETDSIPVEARDGGVTVKVISGATETGTAGPIGGGAVDALYFDVALPAGTVFEEPVGDDRNAMLAVYEGKVRVAHDTVDALSGVFLGRGDTVRVEAVTDARVLLLAGRPIGEPVFWHGPFVMDTREGLMQAFDDFQRGRF
What are the official names of this protein?
Pirin-like protein CC_0481.
What is the protein family that this protein belongs to?
Belongs to the pirin family.
Protein: UVRC_GLOVI
Sequence: MPNLIADPERLKERLELLPTSAGVYLMRDEAGEILYVGKAKNLRNRVRSYFQPGHDHSPRIAIMVGKVHDFELILTDTEAEALVLEDNLIKTHKPRYNVLLKDDKQYPYLCITWSEEYPRIFVTRRRGSGHPEDRYFGPYTDAGALHSTLGLLKKLFPLRQRNTPVFKDRPCINYEMGRCPGLCQRLISPQEYRATIRQIQMILQGRTAELLAQLEDQMQTAAAAMNFEHAARLRDRITGLNQLGAHQKITVPDSSVSRDAVALAADAALVSIQLFQVRSGKLIGRLGFSAAASGEDPGHILQRVLEEHYRASASEEIPLEVLTQHPLPEADILATWLAEKKGRKVEIHAPQRQIKAELVEMVARNAEAELQRLERFSRRQEKGLLNLAEALELPSVPRRMECYDISHIQGTDTVASRVVFVDGAPAKQYYRHYKIRDPRIVAGRPDDFASMAEVISRRFARAESEPEGDLPDLVVIDGGKGQLSAARAVMEELSYGDVPTIGLAKRLEEVFLPGRSDPVLIAQGDPALHLLQRIRDEAHRFAVSFHREQRGKRMTRSSLDDIPGIGPAKRKILLDTFRSVPVLEKASFEEIAKTPGIGSRLAQVIHTYFHGEPEAVARALEAEQAAN
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACA_STAAU
Sequence: MAIIIGSDEAGKRLKEVIKSYLLDNKYDVVDVTEGQEVDFVDATLAVAKDVQSQEGNLGIVIDAFGTGSFMVATKIKGMIAAEVSDERSGYMTRGHNNSRMITMGSEIVGDTLAKNVVKGFVEGKYDGGRHQIRVDMLNKMC
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacA.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: MUTS2_LIGS1
Sequence: MNKKVLKTLEYDKVKQNLYAFTTTSMGKRLIDKLEPSSDYDEISNSLAQTKDGADILRIKGGIPVPNLISIKSFLKRLDIGGTLNSKELAAIGRVLRATNEVNRFFKDLADNKIKLEVLFDDVAKLESLPEISKKLLVSIENDGHVTDDASTLLKSIRQQISVTEETIRERLNAYTRGTNSKYLSNAVVTIRNERYVLPVKQEYRSKFGGIVHDQSSSGQTLFVEPAVIVELNNRLRQQQVAEREEINRILEELSKELAPYTHELNNNAKILGMLDFINAKAKYAHSIKATEPILSKENDVYLRQVWHPLLDMKKAVKNDIMIGKDYQAIVITGPNTGGKTITLKTLGLVQLMGQSGLYIPAFEESRIGIFDDIFADIGDEQSIEQSLSTFSSHMTNIVEILKGIDEKSLVLFDELGAGTDPQEGAALAISILDAVGAKGSYVVATTHYPELKAYGFERPNTINASMEFDANTLQPTYRLLIGIPGRSNAFDISQRLGLDKMIVMAARQLTSQDSQDLNEMISDLVAKRHDAEEKEIMYRKYLREAEELHHDLETNFHQFERQKENMLEQAKERANQIVEETKKKSDELISELRKMKMSAASNIEEGSLIDAQGRVNALHQETNLKKNKVLRKAKQQQELHPNDDVMVNSYGQRGVLLRKAGNHAWEVQLGILKMKIDESDLEKIKVKDTQPKRAGAVLKSSSSSHVSPTLDLRGERYENAMVKVDRYIDAAVLAGYNSVTIIHGKGTGALRTGIINYLKQNKAVKNFEFASPNNGGNGATVVYFK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: Y1094_HALWD
Sequence: MSEVPPTDEGWFVLHDFRTVDWDAWREAPTHRREAAVGDGVEYLRKHESIADAEEGSSAVFSVLGHKADILITHFRPTLDALSRAERQFEQTTFAGFTTQPTSYVSVAEISGYTTPGYFENPDAADEGLRQYMQGKLTPEIPNKDYAGFYPMSKRRGETYNWYDLPIDERAEMMEAHAETGKEYAGKIKQVIASSVGFDDYEWGVTLFADDPTDIKDIVYEMRFDEVSAKYGEFGTFYIGQRFPPADLGALLEGKAIPTVEQDVDAPTAHGEAHGHAHGDSPHGSGGGGGSSHGQSPGGASAGGSAHGTEDADHSDSRSTTSADTTQSDTSTNTNTQDSEIREQLAEYDIYAGQPHGEDVYATVLYSEATTDELFSEVEGLRGNFDHYGTHVKTAVYEARNRHRNAVVSIWETQSAAETAAGFISELPDVVSRAGEESGFGTMGMFYTVKSEYRGEFNDTFDTVGGILTEMDGHQQTDLMINLEDENDMFISSQWDAREDAMSFFRSDEFSETVEWGRDVLSERPRHVFLA
What are the official names of this protein?
Putative heme-binding protein HQ_1094A.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the ChdC family.
Protein: ILVD_RHORT
Sequence: MTPYRSRTSTHGRTMAGARGLWRATGMKDEDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAAEIAAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADAVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGKVVLGGTERSVDLIDAMVVAGDAKVSDADVETIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSALATHVARRGLFEEAGRRIVDLAKRRYEHDDESTLPRAIASFKAFENAMSVDIAMGGSTNTVLHLLAAAQEGEVPFTMADIDRLSRRIPHLCKVSPSTADFYMEDVHRAGGVMGIMGELSRAGLLHEDLPTVHTPTLKAALDHWDIRRPVDDAVRAFFRAAPGGVRTVVPFSTDRLWDSLDDDRETGCIRDLDHAYSRDGGLAVLYGNLAPNGCIVKTAGVDASILTFTGTVRLCESQDEAVARILGGEIQAGDVVLVRYEGPKGGPGMQEMLYPTSYLKSRGLGKVCALVTDGRFSGGSSGLSIGHVSPEAAAGGPIGLVEEGDIIVIDIPARSIVVDLSDEELAARRSAMEARGRAGWKPAKPRKRAVSPALRAYAALTTSADRGAVRDVSQVER
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RECR_ECO57
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQEVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLAEEKITEVILATNPTVEGEATANYIAELCAQYDVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIRF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: MECA_STRZT
Sequence: MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKIDQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFAKLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLNLQKIG
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: RIR2_PLAF4
Sequence: MADVINISRIPIFSKQEREFSDLQKGKEINEKILNKESDRFTLYPILYPDVWDFYKKAEASFWTAEEIDLSSDLKDFEKLNENEKHFIKHVLAFFAASDGIVLENLASKFLREVQITEAKKFYSFQIAVENIHSETYSLLIDNYIKDEKERLNLFHAIENIPAVKNKALWAAKWINDTNSFAERIVANACVEGILFSGSFCAIFWFKKQNKLHGLTFSNELISRDEGLHTDFNCLIYSLLDNKLPEQIIQNIVKEAVEVERSFICESLPCDLIGMNSRLMSQYIEFVADRLLECLGCSKIFHSKNPFNWMDLISLQGKTNFFEKRVADYQKSGVMAQRKDQVFCLNTEF
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase small chain, Ribonucleotide reductase R2 subunit, Ribonucleotide reductase small subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family.
Protein: TRPC_PROM5
Sequence: MEIRRRPPNPTVRVENLEYAVPHREAKAKNILEEIVWYKDIEIKNFKKIVSLEDLIKKLDKLPPTKDFGKSILQSKIKPGVIAEIKKASPSKGVIREDFRPNEIAFSYERSGASCISVLTDKRFFQGSYEILQDVRGATNLPLLCKDFIISAYQIYKARVSGADAILLIAAILSDDDLFYLKKIADNLGMSVLVEVHDEQELKRILSFKLFDLIGINNRDLKTFKTDLKTSIEMMSKYSDIFSKHNIIPISESGINNSEELKKLVSIGIKGVLIGERFMRECDIEHSFKKLFKSI
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: MEIOB_MACFA
Sequence: MANSFATRTFTTLSDLQPNMANLKVIGVVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPAHFVNAASWGNEDYIKSLSDSFRVGDCVIIENPLIQRKEIEREEKFSPATPSNCKLLLSENHSTVKVCSSYEVDTKLLSLIHLPVKESHDYYSLGDIVANGHSLNGRIINVLAAVKSVGEPKYFTTSDRRKGQRCEVRLYDETEFSFAMTCWDNESILLAQSWMPRETVIFVSDVRISFDKFRNCMTATVISKTIITTNPETPEANILLNFIRENKETNVLDDEIESYFKESINLSTIVDVYTVEQLKGKALKNEGKADPSYGILYAYISTLNIDDETTKVVRNRCSTCGYIVNEASNMCTICNKNSLDFKSVFLSFDMLIDLTDHTGTLHSCSLTGSVAEETLGCTVNEFLAMTDEQKTALKWQFLLERSKIYLKFVVSHRARSGLKISVLSCKLADPTEASRNLSGQTRV
What is the function of this protein?
Single-stranded DNA-binding protein required for homologous recombination in meiosis I.  Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis.  Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage.  May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination.  Displays Single-stranded DNA 3'-5' exonuclease activity in vitro.
What are the official names of this protein?
Meiosis-specific with OB domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the MEIOB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome. Note=Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22.
Protein: NSA1_PICST
Sequence: MKFLVSSDDTGVVKEVICNRGTDTSKQDATQPISVKNFCTEPNCSRKNRIIHMINYQEKYLVAIRIGGELSVYEIADDEYEIEDEYKYNLLHNYKLEVSSSDKPISLFTVDILEAVAVAFSSGKVFFVNFNDDKFDKEPVLVQLPGGKEIAEFSKNPSVEGIFGYGGEENDVRIVKLYESDITSEIFDTENVENNFKSEVVFTAKNVKNDHLDLRVPVWITKIRFFTEQPEKGYKFITATHYGQIRVYDTNHGRRPVRDFTVCQKPILTLTFANEEESEVIISDSHNLIAKHSLIQVDDKASKTHSASAGDIIKPVAKLLGRFVDQFGATYGVEVGEGLLVTGGLDRYLRVFDLASREIVAKVYVGVEVSSVVVLDYEEEESQEEIVGDVELLKKSEKRKRTLPVVEREESDEEDLWNQLEEKDIKRKKS
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein NSA1.
What is the protein family that this protein belongs to?
Belongs to the NSA1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SPH23_ARATH
Sequence: MQNLSILLVCSFCILGHVSSAGIRIGNELKNKKLLWMRCYSKDDVIGPLIIPIGGHRFNYFGTNIFATTRFMCTLRQGPNYRHHQNFTAFKLYSASDDGGVWDWRAREDGIYLKIKAERGVN
What are the official names of this protein?
S-protein homolog 23.
What is the protein family that this protein belongs to?
Belongs to the plant self-incompatibility (S1) protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: DJLB_ECOLI
Sequence: MKNCWKILDIEETTDVDIIRRAYLALLPSFHPETDPQGFKQLRQAYEEALRIAQSPAKSVWQPEEYEVAEHEILLAFRALLASDSERFLPSAWQRFIQQLNYCSMEEIDELRWSLCTIAMNTAHLSFECVVLLAERLRWLQEENTGEIDEEELESFLYAIAKGNVFNFQTILHLPVAVQNDTIDFYQMFARIWSSHPQWLTLYLAQHRAVIIPDDAKLHRNLLRWYSAGRLDIPELLDYAQSWRETEPDNEDAPYYEYAQRVYCGEGESLLAELCDYWREYPSTQADALMLQWCRQHRVDYYPLLVMMIEARDLVNDQGKPLLYVPGDSARTRFHLYEILSDEKLSALGRSLVEMVLHKGRKPRISLTRDTEHTLWPLYLVAKQLVQACQPTEESLMPIVSRLDAENRCPLEALIIRRLLIQAANFTEKQTVEPEPQPQPMPVDDGGPGCLGIIKIIFYIFIFAGLIGKILHLFG
What are the official names of this protein?
Uncharacterized J domain-containing protein DjlB.
Protein: NU2M_PISOC
Sequence: MNRSVVLILLLNIIVSVVIVLSSHSWFSVCDGLELNTLSVLPILCGQFSPRGVESTIKYFLVQAFSAAMILNVALVQLWLCSSWSVSCPLNSFSSIVLTLALCLKLGLFPCHFWFPDVLQGLSFLQGLLLSTWQKVAPFIILVSVCNIISINVLTTLGCLSVLVGGWGGLNQSQVRKIMAFSSISHLGWICSVLSYSIYVGCIMFVVYIVLSSTVFLINNEGNLYNLSSLARLVYCNNVMGNVLVLVILSLGGLPPLTGFLNKFIALECLLSNNLLVPCAILIVGSLLSLFFYLRISFNSVLCLFPQHSMMLFSWRNVSGYYGNTSFYTVLLSILSSMSILGLLLVPALWSYH
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: QUEA_PARD8
Sequence: MKLSKFKFNLPSELIALHPAKNRDESRLMVVHRDTGEIEHREFKDILDYYGKGDVFIFNNTKVFPARLYGNKEKTGARIEVFLLRELNEDLRLWDVLVDPARKIRIGNKLYFGEDDSMVAEVIDNTTSRGRTLRFLYDGNHDEFKKALYALGETPLPKYIEREVEPEDEDRYQNIFAAEEGAVVAPAAGLHFSRELMKRLEIKDCQFAFLTLHSGLGNFREIDVEDLTKHKMDSEQMVVNADVVDIVNKGKDEGHKVCAVGTSVMRAIETAVSTDGHLKEFEGWTNKFIFPPYDFSVATSMVTNFHMPLSTLLMMTASFGGYELIMDAYDIALKEKYRFGAYGDAMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_STRA5
Sequence: MAKKSKNLRAALEKIDSTKAYSVEEAVALAKETNFAKFDATVEVSYNLNIDVKKADQQIRGAMVLPAGTGKTSRVLVFARGAKAEEAKAAGADFVGEDDLVAKIQGGWLDFDVVIATPDMMALVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGKITYRADKAGNVQALIGKVSFDDAKLVDNFKAFNDVIVKAKPATAKGTYITNLSITTTQGVGIKVDPNSL
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: FXYD3_PIG
Sequence: MHEVALSVLILLAGLSALDANDPEDKNSPFYYDWHSLRVGGLICAGTPCALGIIILLSGKCKCKFSQKPSHRPGDAPPLITPGSAHDC
What is the function of this protein?
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell.  Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1.  Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes.
What are the official names of this protein?
FXYD domain-containing ion transport regulator 3, Chloride conductance inducer protein Mat-8, Mammary tumor 8 kDa protein, Sodium/potassium-transporting ATPase subunit FXYD3.
What is the protein family that this protein belongs to?
Belongs to the FXYD family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: Y370_RHIME
Sequence: MTDTGWIDLALVSARPQAMGALLRYFRNLDLAEEAFQEACIRALKNWPRTGPPRDPAAWLIFVGRNSGIDKVRRQSRETALPPEELLSDLDDRESELADRLDGAHYRDDILRLLFVCSNPALPATQQIALALRIVSGLSVRQIARAFLVSEAAMEQRITRAKARVAAAGIPFETPDAVDRAERLAAVATMIYLVFNEGYSAMNGPEGVSADLCDEAIRLSRLLLRLFPAEPEMMGLTALLLLQHSRARARFDANGAVVLLEDQDRRLWSRPMITEALAMIDKAMRHRRPGPYQIQAAIAALHARAERPEQTDWEEIDLLYQALERLQPSPVVTLNRAVAVSKREGPEAALAMVEPLGERLSGYFYYHGLRGGLLKQLGRACEARTAFDRAIALATNASEAAYIRMQLDHLAAEPATVAEEEKR
What are the official names of this protein?
Uncharacterized protein R00370.
Protein: MAFF_CHICK
Sequence: MAADGLSSKALKVKRELGENTPLLSDEELMGLSVRELNHHLRGLSKEEVARLKQRRRTLKNRGYAASCRVKRVCQKEELQKQKMELEWEVDKLARENAAMRLELDTLRGKYEALQGFARTVAAHGPPAKVATASVITIVKSGANQAAYS
What is the function of this protein?
Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerizes among itself.  May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites.  May be involved in the cellular stress response.
What are the official names of this protein?
Transcription factor MafF, V-maf musculoaponeurotic fibrosarcoma oncogene homolog F.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Maf subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCH1L_ECOLI
Sequence: MKNTELEQLINEKLNSAAISDYAPNGLQVEGKETVQKIVTGVTASQALLDEAVRLGADAVIVHHGYFWKGESPVIRGMKRNRLKTLLANDINLYGWHLPLDAHPELGNNAQLAALLGITVMGEIEPLVPWGELTMPVPGLELASWIEARLGRKPLWCGDTGPEVVQRVAWCTGGGQSFIDSAARFGVDAFITGEVSEQTIHSAREQGLHFYAAGHHATERGGIRALSEWLNENTDLDVTFIDIPNPA
What is the function of this protein?
Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides.
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog, Radiation resistance protein YbgI.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Protein: YTXD_PRIMG
Sequence: MKKIDMLTPIGILIGISMVVFGVISSGGNERFLAFIDVPSILIVLGGVFGTLCVSFPLKQLKNMGRVGKQAFQSKEINVEEIVGTFVHLSEKARREGLLSLEAELEQIDDSFVKKGILLAIDGVEPEMIRELLEAEIATVEERHARGRSMFEKAGDYAPAWGMIGTLVGLVLMLKSLNTPSSLGPDMAIALLTTFYGALLSNLFFQPIAAKLAGKTEHELFVKEVIIEGVIGLLAGQNSRFVQAKLKVFAPVEKRKLEEKREHVREA
What is the function of this protein?
May be involved in some transport function.
What are the official names of this protein?
Uncharacterized 29.3 kDa protein in ccpA 3'region, ORF1.
What is the protein family that this protein belongs to?
Belongs to the MotA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS18_LEIXX
Sequence: MAGKSSGDRRKPIRKGKDGKNAAPAKSVRVGVIDYKDVATLRKFISERGKIRALRITGVSVQEQRLIARAVKNAREMALLPYAGSGR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: T23O_XANCP
Sequence: MPVDKNLRDLEPGIHTDLEGRLTYGGYLRLDQLLSAQQPLSEPAHHDEMLFIIQHQTSELWLKLLAHELRAAIVHLQRDEVWQCRKVLARSKQVLRQLTEQWSVLETLTPSEYMGFRDVLGPSSGFQSLQYRYIEFLLGNKNPQMLQVFAYDPAGQARLREVLEAPSLYEEFLRYLARFGHAIPQQYQARDWTAAHVADDTLRPVFERIYENTDRYWREYSLCEDLVDVETQFQLWRFRHMRTVMRVIGFKRGTGGSSGVGFLQQALALTFFPELFDVRTSVGVDNRPPQGSADAGKR
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: GLUQ_CORGL
Sequence: MAGRYAPSPSGDLHFGNLRTALLAWLFARSEGKKFLMRVEDIDEQRSSKESAESQLADLSALGLDWDGDVLYQSTRYDAYRAALEKLDTYECYCSRRDIQEASRAPHVAPGVYPGTCRGLKEEERVEKRATLAAQNRHPAIRLRAQVTSFDFHDRLRGPQTGPVDDFILLRGGQEPGWAYNLAVVVDDAYQGVDQVVRGDDLLDSAARQAYLGSLLGTPAPEYIHVPLVLNAHGQRLAKRDGAVTLKEMLIDAPLHTIFSRLASSLGYEGVNSAPQLLEIFDPTTLSREPFIY
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.