PharMolix/UniProtQA huggingface dataset:
Protein: EFG_NITMU
Sequence: MARKTPIERYRNIGVMAHIDAGKTTTTERILFYTGVSHKLGEVHDGAATMDWMEQEQERGITITSAATTCFWKGMDHNYPDHRINIIDTPGHVDFTIEVERSLRVLDGACTVFCAVGGVQPQTETVWRQANKYKVPRLAFVNKMDRAGANFMRVYEQIQSRLKAHPVPIQLPIGAEDKFEGVVDLIKMKAIHWDDASQGMRFEERDIPANMVEDAKSWREKMVESAAEANEELMNKYLEEGDLSPADIKQGLRIRTLANEIVPMLCGSAFKNKGVQAMLDAVLDYLPSPADIEAIDGEKESGEHAERHASDEEPFAGLAFKIATDPYVGQLIFFRVYSGVVTSGDTVYNPIKGRKERIGRLLQMHANQREEIKEVRAGDIAAAVGLKEAVTGDTLCDPADVITLERMVFPEPVIHVAVEPKTKLDQEKMGIALNRLAQEDPSFRVRTDEESGQTIISGMGELHLEIIVDRMKREFGVEANVGAPQVAYREAIRKSVDVEGKFIKQSGGRGQYGHVWIKMEQNEAGKGFEFIDAIKGGTVPREYIPAVQKGLEETLPNGVLAGFPVVDVKVTLFDGSYHDVDSNENAFKMAASIAFKDGMRKANPVLLEPMMSVEVETPADFMGNVVGDLSSRRGMIQGMDDLPGLKVVRAEVPLAEMFGYATSLRSATQGRATYTMEFKHYAEAPKNVAEAIISKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_BRUSI
Sequence: MIKISIDAMGGDFGPEVVIPGAAKAFERHPDIRFIFFGLPAQVEPVLARYPKLKEASEFRASEVAIGMDDKPSQALRAGRGKSSMWQAIEAVKTGDADACVSAGNTGALMAMSKFCLRMMSDVERPAIAGIWPTLRGESIVLDIGATIGADARQLVDYAVMGAGMARALFEVRKPTVGLLNVGTEEVKGLDEIKEAGQILRDTPLDGLEYSGFVEGNDIGKGTVDVVVTEGFTGNIALKTAEGTARQMAELLRQAMSRTLLAKIGYVFAKGAFDRLREKMDPNKVNGGVFLGLSGIVIKSHGGANAEGFCSAVEVGYDMVRNRLLEKIEADLAHFHHSHSHVSSKA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: AROE_BORPE
Sequence: MTLPASPPRYAVIGNPIAHSRSPQIHAMFSAQTGRPLRYERLLAPVDGFLPTVQAFRESGGLGLNVTVPFKLEAYALAEARLSERARLAGAVNTLSWRDGAWHGCNTDGVGLVNDLLRLGVALAGARVLLVGAGGAARGVLQPLAAAGCARIHIVNRTAARAAELAAAWRAAAPRTGTQVSAGALAQAAEPGGWDVAINATASGLQGAAPDLPGGLYAPDALAYDMMYGARPTAFMRQAEADGAARCADGLGMLVGQAAESFHIWHGVRPDPGPVLLALRTELLAAG
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: ARLY_ECOUT
Sequence: MALWGGRFTQAADQRFKQFNDSLRFDYRLAEQDIVGSVAWSKALVTVGVLTAEEQAQLEEALNVLLEDVRARPQQILESDAEDIHSWVEGKLIDKVGQLGKKLHTGRSRNDQVATDLKLWCKDTVSELLTANRQLQSALVETAQNNQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLARDESRLQDALKRLDVSPLGCGALAGTAYEIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSAAAIGMVHLSRFAEDLIFFNTGEAGFVELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCQEAAQQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKALEDLPLSELQKFSQVIGEDVYPILSLQSCLDKRAAKGGVSPQQVAQAIAFAQARLG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRITZ_DROME
Sequence: MLLSETHFWTTLREDVVRIKSQDLGAFRYLRQRDKEQEQQDLACLAKRDYTERRNGLAVLKNSGRKSTGRLKDNLKKLEDLLRQHRIIHSEWQDAAQVLLLFSHGLIAHICVDIYTGDILRMVFEKYLVGKLASEVITDAFFTRSHIVLAYNTNQLTVVHLQRPNARSQGPEKIANMDPRIFHVIIPGATERKLSRHLTVNASFDLFVVWTQSSQNEVYPWRPTIRDQDRANIHVFKIKGLQLESIAYCWSENDPLCVDFLRSSESQIITLEQKVSRKGDISAEICSYELAAGKMQRTAITSIPMGAQICSFAFSPDQEKLFLGSVDRNICLHDLVQQSTKYANQIEIVPNQCAWHCDSAMLCVANERSVLQCFDLALATIGHQLVSENVTPSSLLDLSHYFVAQPTLLSVAFSRKPDLSTFKHTYAQTDCLLLLVYEQGPLACMRIFGGTGMRGDIHNSGLTADVIADKYLRLQQPDRAVNVLAALNWETYGAMCLITLHKIANYVFFGGDQRRPRIELMARALKTFAHTLSEETKDEFSDQVYDLKRRFCFYLLRKNLFAEAFEIAQDVADYDIFMDLYNLTKCISSLSEFAQVAFSQAAAIIHEEDRANGNLSLTCDLRSESACSLSTCSDMLRGQGAGTAPETGLGASQPQSQQVLKNYVPPLPSFKSKVFNAEMIKINIPKPELRPPLPKVSIAPPTSSLASLTLKSNSSLQQAPAKSLHPNGNLWSQDVPDQTVGLPMASSPLPRLPPSNIPDQSAQLGQFSTMPASPPPTGSYQPKFYQHPLVSGNIPAMLPSLTSEDYQKRLLQKKPTASILSNPANPAPTNGEAPATPAKSQTAEKNKVKFSDTIQVAVVPEIPRKEKPMPPKRNGYSRPAARHLTNPKKELADSLPLCHPNDEYLKDFNPITTNVTKPPIRRREEEPKSSSKGGNSSSSSSSIKVVHFGVV
What is the function of this protein?
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements.  Functions cell autonomously to regulate wing cell hair polarity and number.
What are the official names of this protein?
WD repeat-containing and planar cell polarity effector protein fritz.
What is the protein family that this protein belongs to?
Belongs to the WD repeat fritz family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm, cytoskeleton, cilium axoneme.
Protein: MPRF_STAEQ
Sequence: MTQELKSKLLSFFKFIFATALFIFVIFTLYRELSHINFKETFIQFGKINRLWLVLLFAGGGLSLILLSLYDIILVKALKLKMPLIRVFRVSYIINALNSIIGFGGFIGAGVRAFVYKNYTNDTKKLVQYISIILVSMLTGLSLLSILVVLRIFNASHMIDEISWVRWILYIVALFLPIFIFYTVARPVDRNNRYMGVYCTVVSCVEWMAAATVLYFAALIVDIHISFMTFVGIFVIAALSGLVSFIPGGFGAFDLVVLLGLKSLGISEEKILLALVLYRFAYYFVPVMIALILSSFEFGNTAKKYLDNSKYFIPVKDFTSFLRSYQKDILAKVPSFSLAILIFLTSIIFFINNLTIVYDGLYDGNHFAYYIALAIQTSACLLLILNVRGIYKGSRRAIIYAFISIILIASATIYTYASFLLLSWLIIIFVLLILAYQRAQVLKRPLRFKKLAFMLLLSIFILYLNHILISGTLYALDVYHIEIDTSLLRYYFWMTIVIIMLLVGVIAWLFDYKYKRPHHSIDLTLCDAIIQKYGGNYLSHLVYSGDKDCFFNENKDSFIMYRYKSNALVVLGDPIGNTKSFESLLEAFYQFAEYQGYEIIFYQISDQYMPLYHNFGNQFFKLGEEAIIDLTTFTTSGKKRRGFRATLNKFDDLNINFEIIEPPFTQDFFDELKFVSDKWLDGRSEMHFSVGQFTQTYLSKAPIGVMRDHSGKMIAFCSLMPTYSNNAISVDLIRWLPELDLPLMDGLYLHMLLWSKEKGYKAFNMGMATLSNVGQLHYSYLRERMAGRVFEHFNGLYRFQGLRRYKEKYSPNWEPRFLVYQKHYSLWESMLKVMRVIRHK
What is the function of this protein?
Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge.  LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins).  In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides (By similarity).
What are the official names of this protein?
Phosphatidylglycerol lysyltransferase, Lysylphosphatidylglycerol synthase, LPG synthase, Multiple peptide resistance factor.
What is the protein family that this protein belongs to?
Belongs to the LPG synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LPPW_MYCTO
Sequence: MRARPLTLLTALAAVTLVVVAGCEARVEAEAYSAADRISSRPQARPQPQPVELLLRAITPPRAPAASPNVGFGELPTRVRQATDEAAAMGATLSVAVLDRATGQLVSNGNTQIIATASVAKLFIADDLLLAEAEGKVTLSPEDHHALDVMLQSSDDGAAERFWSQDGGNAVVTQVARRYGLRSTAPPSDGRWWNTISSAPDLIRYYDMLLDGSGGLPLDRAAVIIADLAQSTPTGIDGYPQRFGIPDGLYAEPVAVKQGWMCCIGSSWMHLSTGVIGPERRYIMVIESLQPADDATARATITQAVRTMFPNGRI
What are the official names of this protein?
Putative lipoprotein LppW.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GREA_RICBR
Sequence: MMAKFPITDQGFEKLEHELKHLKHVERKKVSEDIAEARAHGDLSENAEYEAAREKQAFVEARIKHLEDITARAEIINVAKLSGDSIKFGATVVLIDDETEEEVMYHIVGEYEADITKKRVSIASPIAKALIGKSVGDIVEVMTPGGVKSYEVVTIKYEELVF
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: TRMFO_PSELT
Sequence: MKVHVVGAGLSGSEIAYQLAIRGLKVILHEMRPSKMTPVHKTSYFAELVCSNSLKSDSIKNASGLLKRELELFGSLILRVARNCAVPAGKALAVDREEFSKQVTHVIRESGIDIVIEELRYIPDSKEDIWIIATGPATSDSFASWLREKVGHNMYFFDAVSPIITADSIDYSVVFRADRYGIGNQDYLNCPMNEYEYDRFYEALINAEVLPVKDFEKDLLFERCKPIEDIAKSGKRSLLFGPMKPTGIIDPRTGKQPFAVVQLRKENLDETLYNIVGFQTRLKWGEQRKIIRLIPGLEKAEIVRYGVMHKNIYINSRKVLDPFMRLKNDRKIFFAGQITGVEGYLESVASGLYVALNVYRISKNQEPLELPKSTMTGCLLNYILKGTDTTLQPMYANYGLMGPANKNREEVAKTALRDLENFLNYSQWKEGGIRENTVKGF
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSGA_ECO57
Sequence: MKLLKVAAIAAIVFSGSALAGVVPQYGGGGGNHGGGGNNSGPNSELNIYQYGGGNSALALQADARNSDLTITQHGGGNGADVGQGSDDSSIDLTQRGFGNSATLDQWNGKDSHMTVKQFGGGNGAAVDQTASNSTVNVTQVGFGNNATAHQY
What is the function of this protein?
Curlin is the structural subunit of the curli.  Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius.  Curli can bind to fibronectin.
What are the official names of this protein?
Major curlin subunit.
What is the protein family that this protein belongs to?
Belongs to the CsgA/CsgB family.
What are the subcellular locations of this protein?
Fimbrium. Note=Part of the curli surface structure.
Protein: LIPA_PICST
Sequence: MIALRVHNTRVVSRSLTVWTRPSPTLTLSRSLATESDALDKPKTRRRKTVFTDALNSGPSFDDFVSGKASEIMDPLEAARKDPNQRLPSWLKVPIPKGKSYHNVKKDVRELKLATVCEEAKCPNIGECWGGKKSEATATIMLLGDTCTRGCRFCSVKTNRNPAKPDPMEPENTAEAISRWGLGYVVLTTVDRDDLADGGAHHLAETVMKIKQKAPQILVEVLGGDFRGDLDMATVLAKSGLDVYAHNLETVEALTPFVRDRRATYRQSLSVLQRAKETKSSLVTKTSLMLGLGETDEQILQTLKDLREINCDVVTFGQYMRPTKRHMKVVEYVTPEKFDYWRDTALEMGFLYVASGPLVRSSYKAGEAFIENVIRKRRHNVGEAPRLAQEIQPKIFRE
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EBO_DROME
Sequence: MGSLPQLSIVKGLQQDFVPRALHRIFEEQQLRHADKVALIYQPSTTGQGMAPSQSSYRQMNERANRAARLLVAETHGRFLQPNSDGDFIVAVCMQPSEGLVTTLLAIWKAGGAYLPIDPSFPANRIHHILLEAKPTLVIRDDDIDAGRFQGTPTLSTTELYAKSLQLAGSNLLSEEMLRGGNDHIAIVLYTSGSTGVPKGVRLPHESILNRLQWQWATFPYTANEAVSVFKTALTFVDSIAELWGPLMCGLAILVVPKAVTKDPQRLVALLERYKIRRLVLVPTLLRSLLMYLKMEGGGAAQKLLYNLQIWVCSGEPLSVSLASSFFDYFDEGVHRLYNFYGSTEVLGDVTYFACESKKQLSLYDNVPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVNGRDPERFLENPLAVEKKYARLYRTGDYGSLKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAELPLVDKAIVLCYHAGQVDQAILAFVKLRDDAPMVTEMQMEARLKDKLADYMTPQVVILEHVPLLVNGKVDRQALLKTYETANNNEGDSSIVLDFDYSQVPEDLKLTARDLFETVGGVIGRSTRATLAPHSNFYELGGNSLNSIFTVTLLREKGYNIGISEFIAAKNLGEIIEKMAANHDAVQLEEESLNACPHLKMEAVPLRLEHRQEVIDIIVASFYNKADLEQWLKPGVLRTDYSDILNDIWNVLVERDLSFVVYDTNTDRIIGTALNFDARNEPEVDIKSKLLIVFEFLEFCEGPIRDNYLPKGLNQILHSFMMGTAEKLNPRENIACMHFMEHEVLRVAREKQFAGIFTTNTSPLTQQLADVYHYKTLLNFQVNEYVHSDGSRPFGDAPDEQRAIVHWKEVGK
What is the function of this protein?
Nonribosomal peptide synthase which is required for the regulation of histamine and dopamine levels in various tissues through their condensation with beta-alanine (PubMed:12900414, PubMed:19715698, PubMed:25229196, PubMed:30705105).  In epithelial glial cells, plays an essential role in the inactivation of histamine, the main neurotransmitter in the optical nerve system, by catalyzing the conversion of histamine into carcinine (PubMed:5782111, PubMed:12486147, PubMed:12900414, PubMed:25229196, PubMed:30705105).  In the cuticle, catalyzes the condensation of beta-alanine with dopamine to form beta-alanyl-dopamine (NBAD), a metabolite involved in the pigmentation and sclerotization of the insect cuticle (PubMed:8580497, PubMed:11934851).  Also, regulates the cuticular hydrocarbon composition in females (PubMed:31118901).  Acts downstream of the body clock to regulate circadian behavioral rhythms (PubMed:17678856).  Can also condense beta-alanine with biogenic amines tyramine, octopamine, and serotonin in vitro (PubMed:12900414, PubMed:19715698).
What are the official names of this protein?
Beta-alanyl-bioamine nonribosomal peptide synthetase ebony, N-beta-alanyldopamine synthase, NBAD-synthase, Protein ebony.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
Protein: NUSB_HALH5
Sequence: MNRRLSRLRAVQALYQMDVIDTSMEKAIESVLDEGEEASSFMSDLVSGTVTHQEELDRLYADHLQGWTVDRIGNVDRAILRMALYELYYVDDIPKNVSFNEAIELAKAFGGEDAGRFINGVLSKTMEAYKPKDK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: TSAD_CAMHC
Sequence: MILGIESSCDDSSIALMDENSLKLNYFSKISQEIKHAKFGGVVPELAARLHTKALPEMIEKIKPYFSEISAIAVTNEPGLSVSLIGGVSMAKALSISLNKPLIAVNHLVGHIFSVFLDKKEIFPLGVLLVSGGHTLVLDISANGKISVLAKTGDDSFGESFDKVAKMLGLDYPGGALIENLAKNCDGNLNFTIPLLHDKRLEYSFSGLKNQVRMEIEKAGEISQSVQENIAASFQKTAIAHIMDKLSKIYEMKKWQNFAVVGGASANSALRTKLENLANKYGSTLHLAPLKFCSDNAAMIARAGVYKYNKKEFINYKNLDIVPHLNYENFKI
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDC1_SCHPO
Sequence: MVMLRTSFPSGSRTKAVRYHTLLRPILQQRFLRACFALLCLCCITSYWFSSGPFISLSFWFLSLVRGFVCFFFMFPYFVMLKSRMSTQKVTKQSLGAQLFYDFSPKSFFLVYLTFAVSVSCLCLFYIKGHASSIRLQWIASPNAYELPSLNERFVYMTYFSHILILALTVEHLYLQRDSPSRPVINVSFFNYIFQNLGWLIRFSFRKSIICCLFTPFSYAILRSYIWRFAALLTSCCRRIAYTKTPPKWPLSLRLLLHSFWMAFIVCLTFQIALLIFRVFLYSGPMIRGKLLSARSNDPNGTLVDGMKTKKKPLTECIATEELWFIAKRDPQRIKSIFQDIDRSVSIWQELYSITESRCKELATSLKILQSTGDFSAATSKKSGLTKKTNIPYSPNSNHEEINSIPLRNKNIFVPPSQGHSPLLEKIKKQGSLPSTTPVNEGGISDIIPKSLYDQVIRFISTFYKAPVFGIFRKTLRRQNEALLPNPWLFCVTVNSLTQLVLKSLKYDTYGVVARDISSILAVYCDTFDVLVSYKRSLVKNHSNSTNLDDDFKNLNSAANALHCGIIDITEKFQDFFTQLNLSPRIERRCWVLFREYKSNS
What is the function of this protein?
Component of the nuclear pore complex (NPC) and the spindle pole body (SPB), which plays a key role in de novo assembly and insertion of both structures in the nuclear envelope.  Involved in the formation of the bipolar mitotic spindle.  Anchors the spindle pole body in the nuclear envelope.
What are the official names of this protein?
Nuclear envelope protein ndc1, Cell untimely torn protein 11.
What is the protein family that this protein belongs to?
Belongs to the NDC1 family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Central core structure of the nuclear pore complex.
Protein: RNZ_STAAM
Sequence: MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRSFQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTINVEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKHLANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQILIQNEDTPNFNFVKDFDSFKV
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: UROK_PONAB
Sequence: MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLAWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRWRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIVGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVVSATHCFIDYPKKEDYIVYLGRSRLNSHTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIHSKEGRCAQPSRTIQTICLPSMYNDPPFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSYFLPWIRSHTKEENGLAL
What is the function of this protein?
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
What are the official names of this protein?
Urokinase-type plasminogen activator, U-plasminogen activator, uPA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEUC_NITSB
Sequence: MGQTITEKIFSEHVGREVKAGEIVECELDMIIGNDITTPISIKAFRDSGAKKLAKPDNFAIVLDHFIPAKDIASANQAKISREFAYEHNLKHFFDEKDMGIEHALLPEKGLVVPGDVIIGADSHTCTHGALGAFATGMGSTDLAYGMITGKNWFKVPPSIKVIYTGKLGEHVYGKDLILELIRRIGVDGALYKALEFTGDTIENLDMDGRFSLCNMAIEAGAKNGIIAVDEVTKAFLADKPLAREPKIHYSDEDAEYEQVIEIDVNNLEPVIAFPHLPSNGRPISEAAKMDLKVDQVFIGSCTNGRLSDIAIAAEILKGRKVARHTRMIVTPATQKILKEAEKRGYIDILIDAGAVVSNPTCGACLGGYMGILADNERCVSTTNRNFVGRMGARTSEIYLANSAVAAASAVAGKIADPREL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: MET_ATEAB
Sequence: MKASAVLAPGILVILFTLVQKSNCECKEALVKSKMNVNMKYQLPNFTAETPIQNVVLHNHHIYLGAVNYIYVLSDKTLQKVAEYKTGPVLEHPDCLPCQDCRHKANLSNGIWKDNINMALLVDTYYDDQLISCGSVHRGTCQRHVLPPNNAADIQSEVHCMYTPQPEEEPSQCPDCVVSALGTKVLLSEKNRFINFFVGNTINSSYLPDHSLHSMSVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYIHAFKSNHFIYFLTVQRETLDAQTFHTRIIRFCSGDSGLHSYMEMPLECILTEKRRKRAAREEVFNILQAAYVSKPGAHLARQIGASLNDDILYGVFAQSKPDSAEPMNRSAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSSCDVRSDEYRTEFTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRLGSSTPHVNFRLDSHPVSPEVIVEHPLNGNDYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPAFVQCGWCHDKCVQLEECPSGTWTQETCLPTIYKVLPTSAPLEGGTTLTICGWDFGFRRNNKFDLKKTRVFLGNESCTVTLSESSTNMLKCTVGPALYEHFNMSIIISNSRGTVQYSTFSYVDPIITSISPTYGPKTGGTLLTLTGKYLDSGNSRHISIGGKTCTLKSVSNSILECYTPPQTTSTEFPVKLKIDLANRNTYSFSYQEDPIIYKIHPIKSFISGGSTITGVGKNLNSVSVLRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLDLQLPLTTRAFFMLDGIHSRYFDLIYVHNPMFKVFEKPVKISIGIENILEIKGNDIDPEAVKGEVLKVGNKSCENIHSYSETVLCTVPNDLLKLNSELNIEWKQAVTSTVLGKVIVQPDQNITEFIVGILSISGILLTLLGLLLWWKKKKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDENFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAELRPSFSELVSRISAIFSTFIGEHYVHVNATYVNIKCVAPYPSLLSSQDNFDSEGNT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.  Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.  Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.  Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.  During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.  In adults, participates in wound healing as well as organ regeneration and tissue remodeling.  Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SYT_MAGMM
Sequence: MVEIILPDGSSRSYDQETLTCGQIAASIGKGLAKAAIAGVVNGQKVDLDAPVPHGAQVAIITEDSPEGLEIIRHSASHLMAQAVKTLFPQAQVTIGPAIENGFYYDFDYERPFTPDDLTAIENCMRKLAKRNEKVERRVMPRDEAVAYFQAMGELYKAEIIGAIPAGEDVSLYSQGEFTDLCRGPHVPSTGKLKAFKVMKAGGAYWRGDSRNKMLQRIYGTAWATEADLKAYLTQMEEAEKRDHRRIGKDLDLFSVQEDAGGGLVFWHPRGSRIRRVIEDFWKDRHVEAGYEFLYTPHIANRQLWNTSGHTDFYSDSMFSPMEVDEQAYQIRPMNCPFHILIYKDRRHSYRELPFRWGELGTVYRYEMSGALHGLFRVRGFTQDDAHIFCTEQQIEEEIQRILDLTLDILRTYGFSDFEINLSTRPEKSVGSAAIWDKATEALRRAIVSRDLSYVVDEGGGAFYGPKIDVKITDSIGRKWQCSTVQLDFNLPERFDMGYIGEDGESHRPIMIHRALMGSLERFFGILVEHYAGWFPMWLAPVQAVVCSITDAQHAYAETVLAALKKAGLRVEIDLRNEKVGYKIREHTLKRVPYLLVVGDKEREEGTVNVRLRSGKSLGSLPIQDVVERLVEEAASRALSASEDQEEA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDB3S_OPICY
Sequence: MQYKTKTFLVIFLAYLVVTNEAEAFWSFLVKAASKILPSLIGGGDDNKSSSKRKREIEDFFDPYQRELDLELERLLSQLQ
What is the function of this protein?
Antimicrobial peptide (PubMed:27917162).  Has antifungal activity against all strains tested with MICs values ranging from 12. 5 to 200 uM (PubMed:27917162).
What are the official names of this protein?
Probable antimicrobial peptide clone Con10.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Medium-length antimicrobial peptide (group 3) family.
What are the subcellular locations of this protein?
Secreted.