PharMolix/UniProtQA huggingface dataset:
Protein: PIMT2_POLSJ
Sequence: MMEEITALVRETRTETGKPALDERVMAVMGKVPRHEFVPADQLPRAYQNRPLPIGHGQTISQPYIVALMTDLARVEPGHKVLEVGTGSGYQAAVMAHLARAVYTIEIIEPLGLQARQRLQKLGYDNVQVRLGDGYHGWEEHAPYDAILVTAAASHIPPPLIRQLKAGGRMVIPVGAAFMVQQLMLVEKNRDGTVSTRQILPVAFVPLTGQR
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase 2, L-isoaspartyl protein carboxyl methyltransferase 2, Protein L-isoaspartyl methyltransferase 2, Protein-beta-aspartate methyltransferase 2, PIMT 2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_METRJ
Sequence: MKFRPLHDRVVVRRIESEEKTKGGIIIPDTAKEKPQEGEVVAVGPGARDEQGRVNALDVKAGDRVLFGKWSGTEVKIDGQDLLIMKESDIMGVVAL
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_DESAH
Sequence: MIILGIESSCDDTAAAVVSDHNTVLSSVVSSQVDVHHRYGGVVPELASRMHIEAISPVVAQAVDQAGISPDQIEGVAVTRGPGLIGALLVGFSFAKAFAWAKNIPWAGVNHLEGHIYSLLLSDDPPAFPFTALLASGGHTSIFHVVSQDRFELLGQTRDDAAGEAFDKVAKMLGLGYPGGAVVEALAAKGDPCLIPFPRSFLDKDGFDFSFSGLKSAVARYVQLNRENLGEMMPHIAAGFQSAVTDVLAFKLIHAARATGCSRIAIAGGVSANRFLASRMKIEAAKHNMALYLPPPSFCGDNAAMIAARGHRLISQGDLCQLDSDVFSRTRFL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CF144_CHICK
Sequence: MAARGGKKEPPDAVHLNRLLYERVRKELRCQRLHTEHSINPLRPVHAVTQKPMSWHDNIEEPADARFLNIIHQAALEPTKKYSEPQTESQEIGWNTTPLTDVDRTDRRLFFPRRRTEITMHSAAGGHPKKQ
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
What are the official names of this protein?
Cilia- and flagella-associated protein 144, Protein FAM183A.
What is the protein family that this protein belongs to?
Belongs to the CFAP144 family.
Protein: CO4A2_CAEEL
Sequence: MKQRAALGPVLRLAILALLAVSYVQSQATCRDCSNRGCFCVGEKGSMGAPGPQGPPGTQGIRGFPGPEGLAGPKGLKGAQGPPGPVGIKGDRGAVGVPGFPGNDGGNGRPGEPGPPGAPGWDGCNGTDGAPGIPGRPGPPGMPGFPGPPGMDGLKGEPAIGYAGAPGEKGDGGMPGMPGLPGPSGRDGYPGEKGDRGDTGNAGPRGPPGEAGSPGNPGIGSIGPKGDPGDLGSVGPPGPPGPREFTGSGSIVGPRGNPGEKGDKGEPGEGGQRGYPGNGGLSGQPGLPGMKGEKGLSGPAGPRGKEGRPGNAGPPGFKGDRGLDGLGGIPGLPGQKGEAGYPGRDGPKGNSGPPGPPGGGTFNDGAPGPPGLPGRPGNPGPPGTDGYPGAPGPAGPIGNTGGPGLPGYPGNEGLPGPKGDKGDGGIPGAPGVSGPSGIPGLPGPKGEPGYRGTPGQSIPGLPGKDGKPGLDGAPGRKGENGLPGVRGPPGDSLNGLPGAPGQRGAPGPNGYDGRDGVNGLPGAPGTKGDRGGTCSACAPGTKGEKGLPGYSGQPGPQGDRGLPGMPGPVGDAGDDGLPGPAGRPGSPGPPGQDGFPGLPGQKGEPTQLTLRPGPPGYPGLKGENGFPGQPGVDGLPGPSGPVGPPGAPGYPGEKGDAGLPGLSGKPGQDGLPGLPGNKGEAGYGQPGQPGFPGAKGDGGLPGLPGTPGLQGMPGEPAPENQVNPAPPGQPGLPGLPGTKGEGGYPGRPGEVGQPGFPGLPGMKGDSGLPGPPGLPGHPGVPGDKGFGGVPGLPGIPGPKGDVGNPGLPGLNGQKGEPGVGVPGQPGSPGFPGLKGDAGLPGLPGTPGLEGQRGFPGAPGLKGGDGLPGLSGQPGYPGEKGDAGLPGVPGREGSPGFPGQDGLPGVPGMKGEDGLPGLPGVTGLKGDLGAPGQSGAPGLPGAPGYPGMKGNAGIPGVPGFKGDGGLPGLPGLNGPKGEPGVPGMPGTPGMKGNGGLPGLPGRDGLSGVPGMKGDRGFNGLPGEKGEAGPAARDGQKGDAGLPGQPGLRGPQGPSGLPGVPGFKGETGLPGYGQPGQPGEKGLPGIPGKAGRQGAPGSPGQDGLPGFPGMKGESGYPGQDGLPGRDGLPGVPGQKGDLGQSGQPGLSGAPGLDGQPGVPGIRGDKGQGGLPGIPGDRGMDGYPGQKGENGYPGQPGLPGLGGEKGFAGTPGFPGLKGSPGYPGQDGLPGIPGLKGDSGFPGQPGQEGLPGLSGEKGMGGLPGMPGQPGQSIAGPVGPPGAPGLQGKDGFPGLPGQKGESGLSGLPGAPGLKGESGMPGFPGAKGDLGANGIPGKRGEDGLPGVPGRDGQPGIPGLKGEVGGAGLPGQPGFPGIPGLKGEGGLPGFPGAKGEAGFPGTPGVPGYAGEKGDGGLPGLPGRDGLPGADGPVGPPGPSGPQNLVEPGEKGLPGLPGAPGLRGEKGMPGLDGPPGNDGPPGLPGQRGNDGYPGAPGLSGEKGMGGLPGFPGLDGQPGGPGAPGLPGAPGAAGPAYRDGFVLVKHSQTTEVPRCPEGQTKLWDGYSLLYIEGNEKSHNQDLGHAGSCLQRFSTMPFLFCDFNNVCNYASRNEKSYWLSTSEAIPMMPVNEREIEPYISRCAVCEAPANTIAVHSQTIQIPNCPAGWSSLWIGYSFAMHTGAGAEGGGQSPSSPGSCLEDFRATPFIECNGARGSCHYFANKFSFWLTTIDNDSEFKVPESQTLKSGNLRTRVSRCQVCVKSTDGRH
What is the function of this protein?
Collagen type IV is specific for basement membranes (Probable).  Together with fbl-1 and downstream of metalloprotease mig-17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells (PubMed:19104038).  Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons (PubMed:25080592).  Vital for embryonic development (PubMed:7691828, PubMed:8045258).
What are the official names of this protein?
Collagen alpha-2(IV) chain, Lethal protein 2.
What is the protein family that this protein belongs to?
Belongs to the type IV collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane.
Protein: RS5_PORGI
Sequence: MAIVYNRVKSTNDLELKDRLVAINRVTKVTKGGRTFTFAAIVVVGNEDGVIGWGLGKAGEVPAAIAKGVEAAKKNLIRVPVHNGTIPHEQAASYGGASVFLKPATTGTGVKAGGAMRAVLDSVGVTDVLAKSKGSSNPHNLVKATIQALAEMRSPLMVAQNRGISVEKVFKG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: HYCC2_PONAB
Sequence: MLGTDRCVVEEWLSEFKALPDTQITSYAATLHRKKTLVPALYKVIQDSNNELLEPVCHQLFELYRSSEVRLKRFTLQFLPELMWVYLRLTVSRDRQSNGCIEALLLGIYNLEIADKDGNNKVLSFTIPSLSKPSIYHEPSTIGSMALTEGALCQHDLIRVVYSDLHPQRETFTAQNRFEVLSFLMLCYNSAIVYMPASSYQSLCRMGSRVCVSGFPRQHEKHWKELCGRIVLDPEFMVQLLTGVYYAMYNGQWDLGQEVLDDIIYRAQLELFSQPLLVANAMKNSLPFDAPDSTQEGQKVLKVEVTPTVPRISRTAITTASIRRHRWRREGAEGVNGGEESVNLNDADEGFSSGASLSSQPIGTKPSSSSQRGSLRKVATGRSAKDKETASAIKSSESPRDSVVRKQYVQQPTDLSVDSVELTPMKKHLSLPAGQVVPKTNSLSLIRTASASSSKSFDYVNGSQASTSIGVGTEGGTNLAANNANRYSTVSLQEDRLGQAGEGKELLSPGAPLTKQSRSPSFNMQLISQV
What is the function of this protein?
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.
What are the official names of this protein?
Hyccin 2.
What is the protein family that this protein belongs to?
Belongs to the Hyccin family.
Protein: GLGB_ACTP2
Sequence: MKTYTYSKQDLSFIEQLSQAYCKDPFSYLGLHQAGDVSVIRVFLPEATTVKILSAVGQILSEALKIDDSGLFVAQLAQQYSSLNYRLRVGYSLAEIDLEDPYRFTSSLLPMDNWLLAEGTHLRPYEILGAHLKTQEGVSGVHFSVWAPNARRVSVVGDFNYWDGRVNPMRFHAESGIWDIFLPNVEKGALYKFEILDSNGNIRLKSDPYAFASQFRPDTASVVTGLPEKIEVDAKLRHANDPDQPISIYEVHLGSWRRHLENNYWLNYEEIANELIPYVKDMGFTHIELLPITEYPFDGSWGYQPTGLYSPTSRFGSPEDLRTLIRKAHEAGINVILDWVVGHFPTDSHGLTEFDGSHLYEHQDPREGYHQDWNTLIFNYGRHEVFNYLSSNALYWTERFGIDGLRVDAVSSMIYRDYSRKDGEWIPNQYGGRENLEALDFLRRTNRMLKKEGHGAVVIAEESTSFAGITHSPEENGVGFDYKWNMGWMNDTLRYMSLDPIYRQYHHDWMTFGMMYQYSEKFVLPLSHDEVVHGKCSILGKMSGDCWQKFANLRAYYGYMWGYPGKKLLFMGNEFAQGREWNYNESLDWFLLGEQGGGWHKGVLNWVRDLNRTYQKYPALYQLDYDPAGFEWLVVDDWQQSVFAFERKAKNGESVIVVSNFTPVVRHNYRIGVRQDGTYTEILNSDAAYYEGSNVGNYGEIECEAIESHGKPFSIELSIPPLSTIFIACQPKPKEAVEAEQDIVKMAEVAMQKALKPTKKTVSVKAKAHKKAHKNKK
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: MIAB_CITBB
Sequence: MNQAKKLYLETFGCQMNVSDSEKIVTLMKGMGYQQTQDPVDADLVLLNTCSIRATAEQRVYGHLGKFKSIKKTKPGLIIGVGGCVAQQEGEKLLKKAPFVNLVFGTHNLHLLQGMVAAAEEGKRSSQTDFLDDEKRFDLFPHSEAEGGVTRFVTVMQGCDNFCAYCIVPHVRGREISRSAAKVVEEVRALADSGVTEVTLLGQNVNSYCSKQPGEPDFPDLLRLVAQVDGIERIRFTTSHPKDMSPRLIECFADLPKLAPHIHLPAQSGSDRVLERMNRGYTAQQYLAKVAALKEACPAIQFTGDMIVGFPGEDEAAFQDTMALMEQVQYADLFSFIYSARPGTKAAEYADDATRAEKQGRLERLQAAQKKTTLARNRSLEGTVQKVLVEGLSSTGDSLFGRTGGNRGTVMAGDPSLAGRVLDVKIVEGLQTLLKGEIVHD
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIAS2_HUMAN
Sequence: MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPISSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSSHESSTHVSSSSSRSETGVITSSGSNIPDIISLD
What is the function of this protein?
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.  Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.  The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied.  However, it seems to be mostly involved in gene silencing.  Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity.  Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation.  Isoform PIAS2-alpha promotes PARK7 sumoylation.  Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.  Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
What are the official names of this protein?
E3 SUMO-protein ligase PIAS2, Androgen receptor-interacting protein 3, ARIP3, DAB2-interacting protein, DIP, E3 SUMO-protein transferase PIAS2, Msx-interacting zinc finger protein, Miz1, PIAS-NY protein, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2.
What is the protein family that this protein belongs to?
Belongs to the PIAS family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, PML body. Nucleus. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity).
Protein: TFDP1_MOUSE
Sequence: MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGKQLLPKTFGQSNVNITQQVVIGTPQRPAASNTIVVGSPHTPNTHFVSQNQTSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGNCSAEDLKVARSLVPKALEPYVTEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSYVGEDDDDDDDFNENDEED
What is the function of this protein?
Can stimulate E2F-dependent transcription.  Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication.  The E2F1:DP complex appears to mediate both cell proliferation and apoptosis.  Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
What are the official names of this protein?
Transcription factor Dp-1, DRTF1-polypeptide 1, E2F dimerization partner 1.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1.
Protein: RS20_CLOBA
Sequence: MANIKSAKKRIKVTETKTLNNRMVKSALKTVIKKFEAAVAGNNVEEAKTAFVAVTKSLDVAASKGVVHKNMAARKKSRLAAKLNAMA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: DCBD1_MOUSE
Sequence: MGTGAGGPSVLALLFAVCAPLRLQAEELGDGCGHIVTSQDSGTMTSKNYPGTYPNYTVCEKIITVPKGKRLILRLGDLNIESKTCASDYLLFSSATDQYGPYCGSWAVPKELRLNSNEVTVLFKSGSHISGRGFLLTYASSDHPDLITCLERGSHYFEEKYSKFCPAGCRDIAGDISGNTKDGYRDTSLLCKAAIHAGIITDELGGHINLLQSKGISHYEGLLANGVLSRHGSLSEKRFLFTTPGMNITTVAIPSVIFIALLLTGMGIFAICRKRKKKGNPYVSADAQKTGCWKQIKYPFARHQSTEFTISYDNEKEMTQKLDLITSDMADYQQPLMIGTGTVARKGSTFRPMDTDTEEVRVNTEASGHYDCPHRPGRHEYALPLTHSEPEYATPIVERHLLRAHTFSTQSGYRVPGPRPTHKHSHSSGGFPPATGATQVESYQRPASPKPVGGGYDKPAASSFLDSRDPASQSQMTSGGDDGYSAPRNGLAPLNQTAMTALL
What are the official names of this protein?
Discoidin, CUB and LCCL domain-containing protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RF3_STRPF
Sequence: MSLTEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVKGKKSGTFAKSDWMDIEKQRGISVTSSVMQFDYAGKRVNILDTPGHEDFSEDTYRTLMAVDAAVMVVDSAKGIEAQTKKLFEVVKHRNIPVFTFINKLDRDGREPLELLEELEEVLGIASYPMNWPIGMGRAFEGLYDLHNKRLELYKGDERFASIEDGDQLFANNPFYEQVKEDIELLQEAGNDFSEQAILDGDLTPVFFGSALTNFGVQTFLDTFLEFAPEPHGHKTTEGNVVDPLAKDFSGFVFKIQANMDPKHRDRIAFVRIVSGEFERGMGVNLTRTGKGAKLSNVTQFMAESRENVTNAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVSPKNVMKQKSFHKGIEQLVQEGAIQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAEVVMTPMGKKTVRWISEDDLDQRMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDVTLEEKM
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_BACTN
Sequence: MIEYVRGELAELSPATAVIDCNGVGYAANISLNTYSAIQGKKNCKLYIYEAIREDAYVLYGFADKQEREIFLLLISVSGIGGNTARMILSALSPAELVNVISTENANLLKTVKGIGLKTAQRVIVDLKDKIKTMGATVAGGSASAGMLLQSASVEVQEEAVAALTMLGFAAAPSQKVVLAILKEEPDAPVEKVIKLALKRL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: HSLO_LACDA
Sequence: MNDYLIKAINASKDLRLLTINGKDLVAEAQKRHDTWSASSAVLGRSLLGTLLLAGAELKGDQELTLRLLGDGPVGAAVVTAKSDLTVKGYVQNNHVALPAREDGHIDVKKAVGKGWLQVTKDLGLKQPYTGEVPIVSGEIAEDLTYYLAKSEQIPSAVGLSVFVNPNDTIGAAGGFLLQALPGASEELLQETEDRIKALPQLSSAFLDGMTPEDLAKKILGDDCKILEKDEVSYHCDCSKEKYAGMLETLKGSQLKEMIDEDHGAELVCNFCGNKYNFTEAELQAILDKKLGK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_BURP0
Sequence: MQIILLEKVANLGNLGDIVKVKDGYARNFLIPNRKARRATKDAIAEFEVRRAELEKVAAEKLAAAQAVGEKLNGQTFEITQKSGVDGRLFGSVTNGDVAELLKKAGYEIEKAQVRMPEGPLKMIGEHGVQVALHTDVVVDVTVNVIGDHA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: LIPB_CERS4
Sequence: MSAVEWSILPGLSPYRETLEAMENRVAAIRAGEAAEAIWLLEHPPLYTAGTSARPEDLVEPERFPVHVAGRGGQYTYHGPGQRVAYVMLDLDRRGRDVRRFVTALEDWVIATLAEFNVRGERREGRVGVWVVRPDRPAGLDGSPREDKIAAIGVKLRRWVSFHGLSINVEPNLTHFEGIVPCGIREHGVTSLVDLGLPVTMQDLDAALLRTFPQHFPD
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_HAEIE
Sequence: MTLKIAIAGAGGRMGRQLIQAVHSAEGVELGAAFERKGSSLVGTDAGELAGIGHLGVAVSDDLESQKDKFDLLIDFTRPEGSLEHIAFCVANNKKMVIGTTGFDQNGKAAIKAASDKIAIVFASNFSVGVNLVFKLLEKAAKVMGDYCDIEVIEAHHRHKVDAPSGTALSMGEHIAKTLGRDLKTHGVFCREGITGERKRDEIGFSTIRASDVVGEHMVWFADIGERVEISHKASSRMTFANGAVRAGKWLENKANGLFDMTDVLDLNNL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNF13_MOUSE
Sequence: MPASSPGHMGGSVREPALSVALWLSWGAVLGAVTCAVALLIQQTELQSLRREVSRLQRSGGPSQKQGERPWQSLWEQSPDVLEAWKDGAKSRRRRAVLTQKHKKKHSVLHLVPVNITSKADSDVTEVMWQPVLRRGRGLEAQGDIVRVWDTGIYLLYSQVLFHDVTFTMGQVVSREGQGRRETLFRCIRSMPSDPDRAYNSCYSAGVFHLHQGDIITVKIPRANAKLSLSPHGTFLGFVKL
What is the function of this protein?
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA.  Plays a role in the regulation of tumor cell growth.  May be involved in monocyte/macrophage-mediated immunological processes.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, APRIL.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Secreted.
Protein: YQ12_CAEEL
Sequence: MLPTSSNNEENRKPENSFPPTHFDTWERLSDYQKPSSSTTDDAYGKPVAKISPTASIDERETGIIGSTLRQDSTDSDSTGSSNMNPYDRLDKEVISKKNAHTNSYRNDVDELEGSLRTLGLQKVNAPTISSFSAWKSQSSALPAPSSSETSKIVKAEIKAPQQPMSLNPNYFDVMREMEKSMNIFTKLFRGSQIRNKNDLPSGRHLVNYRQNHAFDFAAMSHIWKENKMENLPKLPHRANLVMTLPSSRVRNSKICAFYRVLEKKEDKYILVACHVNIHGFHRGDLRFVEVNNRTVLKGFERSSVIGHLFLGDILTVTELTRCNETVSNVASSVEDASPDAPCQWMASKVVLFPRHEPVNVQFKFTCNGMASVVSTNEPMSVILNNLTEAKTNVEYTGIAFKSASYTVHTEDYTKKWYERIQEEISNIMIYPKALSTIYQYEEYTPNFVVEKQEQEEHPYQQDLEDLDLYRQHEMQTNVFTKFFDIGKSEKRKFGPGKSISNCRHSDAIDFAAMSYIWKNIRQQHLPKLPKLPNMVLPLPTSMPLDSEICAFYRVLVENKSKYILIACHMNVHGYHRGDLRFLEINESTKLYGFEGRSVIGQLFLGDIVAVTELARCNGHGSDAFKIPFDVSMSSQNTCTWMASKITLPSRPPPASVLFSFMKNRMAVVKGCDEPMNVEVKSIQNVEPDLIYKGTAFKPEKPELNFTEGFIKKKRHQIGSITLRIASYPNSFGTIYNFQESDIDNEHYKIGINAFSEEKFTEISLDEREKIVETCSLMGFSAANTIFNGRFDCRAFKMEEIKKNGMTVMFCIENPTSQPTLGLWCAGNRIVIGGPNGDVNGAIETVIDDPDIGYLRIAARLSRDIPKKFSFKGDGEFFVSQREVFENEILDDGYFKTLDPGCNGRRIIETLYGGKPLERVVVDKRDSSIERMMSQLFGVGSGISEHKTSGKKSEDTPTQFYFPSTPEPLALNKYQCEYVQMLLDGNPLIIGSSPFGCGKSMTIITAALELYKLKKNRKQLLITQSNYASVNLIDIAQRVCLSGDDDLKDLKFVRFVSEKNWNELPSNCRTDSDMPYLMNKLFKDWAMGRIDLTNLTCLKTHHYVQMVSHIIKNDLVNPMLFGDHIAQIYDKLSADFSRAPHAQTLVEAFFMIYKPDLVMVTADSAKGLLNILRDVCAVQIDEASQLAECTLLGLLKSFNNASFGLIGDIHQLPPYCEEGLEGKLKDFGIGNTMERAIKEKMFPVCTLRNVYRCHPKTTELLSELFYDGALVSGVSELARSDFMTKRDDFWPNPKFPMMFVNNTGASTKMGTSTSNSSEKSIVGEIVQNLINDPRNPVNPSDIGVISFYSAQTSILTEHLRGSGVKCGTVDAFQGSEKEIIIMCSTNERISDFMQLSNRLNVAMSRAKQVTIIIGHLDGLRRANYWSTIVNKIEQNGNLVNANDWYQNQRRNKVSLSSYPLISTSRQSKQQRANEYNSQHKHVKRQSNNDYGSQRSVTNSLNPEFVGKWDDETYGDWPTIQKST
What are the official names of this protein?
Uncharacterized ATP-dependent helicase C05C10.2.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
Protein: VKT3_DABRR
Sequence: MSSGGLLLLLGLLTLWAELTPISGHDRPKFCYLPADPGECMAYIRSFHYDSESKKCKEFIYGGCHGNANNFPTRDKCRQTCRGK
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
Kunitz-type serine protease inhibitor 3, Kunitz protease inhibitor 3, Kunitz protease inhibitor III.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: DCN1_USTMA
Sequence: MSSAAKKEAILRQFRQLTNATPQDANRILKAHGYRIEPATDAFFNNEQAQINASISSSTLDRKSEREVKERLNALFDRFRDAGADSDEEDDEASQPEDRDLISIGGALKMCEALEVSPEDVVFLPLSYYLKSASMGTFTREGYINGWKMLDLSDTIDKQKKTLEKLRQELLDNKPLRLERIAQEKSNPATASGANKGLYEKVYEYTYAFARREGQKSLALENALAFWDLVLPASPTFQRAGSQGTFTQAQLDLWKRFLSEQTRGRAVSKDTWMQFLDFTKEINSDFSNHDFDAAWPSIIDDFVLWVRDNMPASDGMDTS
What is the function of this protein?
May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes.  Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
What are the official names of this protein?
Defective in cullin neddylation protein 1.