PharMolix/UniProtQA huggingface dataset:
Protein: CLK2_MOUSE
Sequence: MPHPRRYHSSERGSRGSYHEHYQSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDHSSDRRLYDRRYCGSYRRNDYSRDRGEAYYDTDFRQSYEYHRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNTKLWDSSRDISR
What is the function of this protein?
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.  Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex.  May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution.  Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation.  Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1.  Phosphorylates: PTPN1, SRSF1 and SRSF3.  Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.  Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (By similarity).
What are the official names of this protein?
Dual specificity protein kinase CLK2, CDC-like kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-141 results in accumulation in the nuclear speckle.
Protein: TXC2B_CUPSA
Sequence: AFGTILKALAKIAAKVVKKLATKPGATYMLKQNLQ
What are the official names of this protein?
Cupiennin-2b, Cu-2b.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 02 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CLCN1_RAT
Sequence: MERSQSQQHGGEQSWWGTAPQYQYMPFEHCTSYGLPSENGGLQHRPRKDLGPRHNAHPTQIYGHHKEQYSYQAQDRGIPKKTDSSSTVDSLDEDHYSKCQDCVHRLGRVLRRKLGEDWIFLVLLGLLMALVSWCMDYVSAKSLQAYKWTYAQMQPSLPLQYLAWVTFPLILILFSALFCQLISPQAVGSGIPEMKTILRGVVLKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSMFSGVYEQPYYYTDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAVIGICCGFLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASLTFPPGMGQFMAGELMPREAISTLFDNNTWVKHIGDPKSLGQSAVWIHPQVNVVIIILLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPEGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKFTIFVEDIMVRDVKFVSASCTYGELRNLLQTTTVKTLPLVDSKDSMILLGSVERSELQSLLQRHLCAERRLKAAQDMARKLSELPYNGQAQLAGEWHPGGRPESFAFVDEDEDEDVSRKTELPQTPTPPPPPPPPLPPQFPIAPSYPEEPNGPLPSHKQPPEASDSADQRSSIFQRLLHCLLGKAHSTKKKITQDSTDLVDNMSPEEIEAWEREQLSQPVCFDFCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIKGHTKSGVQLRPPLASFRNTTSIRKTPGGPPPPAESWNVPEGEDGAPEREVMVPTMPETPVPPPSPEVPSCLAPARVEGELEELEMVGNLGPEEDLADILHGPSLRSTDEEDEDELIL
What is the function of this protein?
Voltage-gated chloride channel (PubMed:1659664).  Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction (By similarity).
What are the official names of this protein?
Chloride channel protein 1, ClC-1, Chloride channel protein, skeletal muscle.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NSRR_KLEP7
Sequence: MQLTSFTDYGLRALIYMASLPEGRMTSISEVTEVYGVSRNHMVKIINQLSRMGYVTAVRGKNGGIRLGKPAGQIRVGDVVRDLEPLSLVNCSSEFCHITPACRLKQALAEAAQSFLKELDNYTLADLVEKNQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: RMI2_CAEEL
Sequence: MCDRDDCASIASRCTGETIICAFVESITPPKIRDKTGTYELKCPFAEGFTMEIGDLFLFHFVFDGSSEKCTRLTPIPKMLAMVYEKLLKDLRKAKKEGKMIISPTAN
What is the function of this protein?
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates (By similarity).  Component of the BTR double Holliday Junction dissolution complex, which is involved in homologous recombination during meiotic double strand break in the germline (Probable).  Plays a role in double strand break repair by positively regulating the accumulation of rad-51 at double strand breaks (PubMed:34252074).  Stabilizes and positively regulates the localization of the BTR double Holliday Junction dissolution complex components rmh-1, him-6 and top-3 at nuclear foci during meiotic recombination (PubMed:34252074).  Positively regulates meiotic recombination, chiasma formation, and chromosome segregation in meiosis (PubMed:34252074).  Positively regulates DNA crossover formation and positioning on chromosome arms (away from the chromosome center) during homologous recombination (PubMed:34252074).
What are the official names of this protein?
RecQ-mediated genome instability protein 2 homolog, RMI2 functional homolog 2.
What is the protein family that this protein belongs to?
Belongs to the RMI2 family.
What are the subcellular locations of this protein?
Nucleus. Note=Co-localizes with rmh-1 in nuclei foci during pachytene in meiotic prophase I (PubMed:34252074). Localization at nuclear foci is dependent on rmh-1 during meiotic recombination (PubMed:34252074).
Protein: 5N3BB_XENLA
Sequence: MRLPVLGKDTVRMRDPEGLQDKITRIQRGGQEKLQIISDFDMTLSRFSRNGERCPTCYNIIDNSNIISDEGRKKLKCLFDIYYPLEIDPKKSIEEKYPLMVEWWSKAHDLFYEQRIQKDRLAQVVKEPQATLRDGYDLFFNNLYQREIPLFIFSAGIGDVLEEIIRQAGVFHPNTKVVSNYMDFDDNGILTGFKGDLIHTYNKNSSVLKDTEYFKEISHRTNILLLGDTLGDLTMADGVSTVENIIKIGFLNDKVEELTEQFLQSYDIVLLRDETLDVVNGILQFVTAKN
What is the function of this protein?
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate.  The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids.  Also has weak activity for CMP.  UMP and purine nucleotides are poor substrates (By similarity).
What are the official names of this protein?
7-methylguanosine phosphate-specific 5'-nucleotidase B, 7-methylguanosine nucleotidase B, Cytosolic 5'-nucleotidase 3B-B, Cytosolic 5'-nucleotidase III-like protein B, cN-III-like protein B, N(7)-methylguanylate 5'-phosphatase B.
What is the protein family that this protein belongs to?
Belongs to the pyrimidine 5'-nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBP_HHV2H
Sequence: MNVATCTHQTHHAARAPGATSAPGAASGDPLGARRPIGDDECEQYTSSVSLARMLYGGDLAEWVPRVHPKTTIERQQHGPVTFPDASAPTARCVTVVRAPMGSGKTTALIRWLGEAIHSPDTSVLVVSCRRSFTQTLATRFAESGLPDFVTYFSSTNYIMNDRPFHRLIVQVESLHRVGPNLLNNYDVLVLDEVMSTLGQLYSPTMQQLGRVDALMLRLLRTCPRIIAMDATANAQLVDFLCSLRGEKNVHVVIGEYAMPGFSARRCLFLPRLGPEVLQAALRRRGPAGGAPPPDAPPDATFFGELEARLAGGDNVCIFSSTVSFAEVVARFCRQFTDRVLLLHSLTPPGDVTTWGRYRVVIYTTVVTVGLSFDPPHFDSMFAYVKPMNYGPDMVSVYQSLGRVRTLRKGELLIYMDGSGARSEPVFTPMLLNHVVSASGQWPAQFSQVTNLLCRRFKGRCDASHADAAQARGSRIYSKFRYKHYFERCTLACLADSLNILHMLLTLNCMHVRFWGHDAALTPRNFCLFLRGIHFDALRAQRDLRELRCQDPDTSLSAQAAETEEVGLFVEKYLRPDVAPAEVVALMRGLNSLVGRTRFIYLVLLEACLRVPMAAHSSAIFRRLYDHYATGVIPTINAAGELELVALHPTLNVAPVWELFRLCSTMAACLQWDSMAGGSGRTFSPEDVLELLNPHYDRYMQLVFELGHCNVTDGPLLSEDAVKRVADALSGCPPRGSVSETEHALSLFKIIWGELFGVQLAKSTQTFPGAGRVKNLTKRAIVELLDAHRIDHSACRTHRQLYALLMAHKREFAGARFKLRAPAWGRCLRTHASGAQPNTDIILEAALSELPTEAWPMMQGAVNFSTL
What is the function of this protein?
Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins.  In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication.
What are the official names of this protein?
Replication origin-binding protein, OBP, OriBP.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae OriBP family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ILVB_CYACA
Sequence: MNYKKNSLIKTGAFALIDMLVKHKVKNIFGYPGGAILPIYDELYHWEKKKLIKHYLVRHEQSAAHAADAYARATNEVGVCLATSGPGATNLVTGIATAQMDSVPIIAITGQVSRAFIGTDAFQEVDIFGITLPIVKHSFVVRDPRDISTIVSEAFYISKHGRPGAVLIDVPKDVGLEEFNYHDYDSIRDHKPITKYRPIYGPSIRQIEKFKKMLLESKQPILYVGGGAVMSRAQHEIEELASFIKIPVTTTLMGKGSFNEYNPLYLGMLGMHGTAYANFAVSECDLLIALGARFDDRVTGKLDEFACNAQVIHVDIDPAEIGKNRIPQLAIISDIKIVLKELLSSMKEGTNNMDKNQTQAWLHRIHKWKKEYPLSIPHDSKLLYPQEVINEISQIAQKAFFATDVGQHQMWAAQFLKVEQGKWLSSSGLGTMGYGLPAAIGAKIANPNDLIICITGDASFQMNLQELGTIAQYELDIKIFIINNQWQGMVRQWQQAFYDQRYAHSNMAKGQPDFVQLANSYGIRGIRVTTSKDLKSKIERIISTPGPLLIDCIVATSENCYPMIAPGKSNSQMLGLTKQLKTITN
What are the official names of this protein?
Acetolactate synthase large subunit, AHAS, Acetohydroxy-acid synthase large subunit, ALS.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NUOD1_SINMW
Sequence: MTEHNVRNFNINFGPQHPAAHGVLRLVLELDGEIVERVDPHIGLLHRGTEKLIEAKTYLQAIPYFDRLDYVAPMNQEHAFALAVERLTGTQVPIRGQLIRVLYSEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERACGARMHAAYFRPGGVHQDLPHQLVEDIGKWIDPFLKTVDDIDELLTGNRIFKQRNVDIGVVSLEDAWAWGFSGVMVRGSGAAWDLRRSQPYECYSDLEFDIPIGKNGDCFDRYLIRMIEMRESARIMRQCVDRLLGDAKVGPVSSLDGKIVPPKRGEMKRSMEALIHHFKLYTEGYHVPAGDVYAAVEAPKGEFGVYLVSDGTNKPYRCKIRAPGYAHLQAMDFLCRGHQLADVSAVLGSLDIVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D 1, NADH dehydrogenase I subunit D 1, NDH-1 subunit D 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TPS3_ARATH
Sequence: MGYDNVCGERQTLLVVANRLPASAKRTGEHSWSLEMSPGGKFNLLVEKDAVSKSLAEMKCIPVFLNEVFDQYYNGYSNGILWPILHHMGLPQEYDHDTIKTFETQYDAYKKANRMFLDVIKENYKDGDIVWCQDYHLMFLPQYLKEYNNKIKVGWFLHSPFPSSEIYKTLPSRSELLRSVLAADLISFHTYDFARHFVNTCTRILGVEGTHEGVVYQGRVTRVVVLPMGIYPNRFIKTCKLPEVIQQMNELKDRFSGKKVILGVDRLDMIKGIPQKYLGFEKFLDENPNWRDKIVLVQIAVPTRNEVPEYQKLKNQVHRLVGRINGRFGSVSSLPIHHMDCSVDSNYLCALYAISDVMLVTSLRDGLNLVSHEFVACQEAKRGVLILSEFAGAGQSLGAGALLVNPWNVTEVSSAIKKALNMPYEERETRHRVNFKYVKTHSAEKWGFDFLSELNDAFDESELQIRKIPHELPQQDVIQRYSLSNNRLIILGFYGTITEPRNSLSKEMDLKLNPELKETLKALCNDPKTTVVVLSRSGKNILDKNFGEYKIWLAAENGMFLKHTTEEWVTNMPQNMNLDWVDGLKNVFKYFTDRTPRSFFEASKTSLVWNYEYADVEFGRAQARDLLQYLWAGPISNASAEVVRGKYSVEVHAIGVTKEPEIGHILGEIVHKKAMTTPIDYVFCSGYFLEKDEDIYTFFESEILSPKLSHETRSKSSSSNHSLEKKVSLNVLDLKQENYFSTAIGQARTKARYVVDSSHNVVNLLHKLAVANTTTTSVKKPNV
What are the official names of this protein?
Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 3, Trehalose-6-phosphate synthase 3, AtTPS3.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the trehalose phosphatase family.
Protein: KRH2_DROME
Sequence: MSAPTDQPPRSEGAQTNSSERSSQQQEQPQQSQSQNVPAKLLQHFQTNRIDSALWALRLLVIFFTVSYVLPIFTSQQSAFSKVMLANAAISALRLHQRLPAFAFSREFLARLFAEDSCHYMMYSLIFFNIRPSLLVLIPVLLYSVLHASSYSLKLLDLIGQNSWWGARFIISIVEFQAANILKATAFCEIFIMPYAIVLAFMNHAGLMTPVIYYHYLVMRYSSRRNPYPRNAFAELRITFEALAARSPPAFAKIIRGGIGFVNRLAPQLQPAAAQE
What is the function of this protein?
Member of the dosage-dependent hierarchy effective upon white gene expression.
What are the official names of this protein?
Krueppel homolog 2, Protein Kr-h2.
What is the protein family that this protein belongs to?
Belongs to the PER33/POM33 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RFCL_SULAC
Sequence: MPLQWFLKYRPKSLQEVENQDEVKEELKKWIESWLNGEPTAKAVLLYGPPGVGKTTLAEALARDYKLELLEMNASDSRNLRDIKDVAERASISGSLFGIKGKIILLDEIDGIYSRADAGAIPAILELIEKTKYPVILTANDPWDPSLRSLRNAVKMIELKRLGKYPLKRLLKRICEKEKIVCIDEALDHIIEQSEGDARYCINMLQGIAEGYGKVTLDNVKELVRRKDRELDPFETLRDVFWAKYYWQAKNAVTNSQVDYELLMRWFDENIPLQYTSMEDVWRAYEALSRASVFLTRAKQVGWDLLSYVFDLMGPGIAFASLEKKKPGYKARWVKYQFPQYIQALARTKEKRDSIETLLKKIGEKTHTSKRKVLNDTLPFLASYYTRHAEAVENYLQLTEGEKEILNVFTQASKPTSEEKAEKSKKYYPKRSSSRKT
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C large subunit, RFC large subunit, Clamp loader large subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcL subfamily.
Protein: RHAA_LISMF
Sequence: MGHETEISKRYQVAKERYQAIGVDTENALKTLKDIKISMHCWQGDDVKGFLNPDGELTGGIMATGNYPGAAHTPKQLRQDLEKAYSLIPGKHKLNLHAIYVDTDEKVDLNEIEPKHFTPWVEWAKEQGLGLDFNPTFFSHPMFKDNYTLASPDKEVRDFWIEHGKRSRKISEYFGKELGQTSINNFWVPDGIKDCPIDRYTPRKRLMEALDEVFAEKLDEKYTQEAVESKLFGLGAEAYTVGSHEFYMGYGITRDKLICLDAGHFHPTEVISNKLSSLALFSKGVMLHVSRPVRWDSDHVVIMDDELIEIGRELVRNDLLGITNIGLDFFDATINRIAAWVVGTRNTQKSLLKALLEPTADLKKMELENDFTSRMAITEELKDFPFGDVWNYFCEINGVPVGLDWLKEVKAYEEDVLLKR
What is the function of this protein?
Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
What are the official names of this protein?
L-rhamnose isomerase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_ECO57
Sequence: MTIKLIVGLANPGAEYAATRHNAGAWFVDLLAERLRAPLREEAKFFGYTSRVTLGGEDVRLLVPTTFMNLSGKAVAAMASFFRINPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTEMWFTDGLTKATNRLHAFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_PSYCK
Sequence: MGLRLNELSPGVGAKKTAQRRGRGIGSGLGKTGGRGVKGQKSRSGSSIRSGFEGGQMPLYRRLPKFGFTSKMAMTTAEVRLSELSQIEGDVVSIETLKAANLIRRDMKRARVMLSGEVTKAYTFKGIKVTKGAKQAIEAAGGSIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: IGHA2_HUMAN
Sequence: ASPTSPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNSSQDVTVPCRVPPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTYAVTSILRVAAEDWKKGETFSCMVGHEALPLAFTQKTIDRMAGSCCVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGKREGPQY
What is the function of this protein?
Constant region of immunoglobulin heavy chains.  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).  Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
What are the official names of this protein?
Immunoglobulin heavy constant alpha 2, Ig alpha-2 chain C region, Ig alpha-2 chain C region BUT, Ig alpha-2 chain C region LAN.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: CARTF_RAT
Sequence: MLASSQMTSVSEEKPIGGSLPAVSTDALEDSASSYSLHSQASLVGPRKSGTRTLEEPLLAPLQPLSCNTPMWACRLRSCEKIGDSYRGYCVSETELESVLTFHKQQTQTVWGTRQSPSPAKPATRLMWKSQYVPYDGIPFVNAGSRAVVMECQYGPRRKGFQLKKISEQESRSCHLYKATCPARIYIKKVQKFPDYRVPTDPQIDRKTIRMEQEKAFTMLKKNLVDAGGVLRWYVQLPTQQAHQYHEPETPGVPLSPSPFPMSPLEEEEAIIRDENCVLPSRLHPQVAHKIQELVSQGVGQVYAVRKQLRKFVERELFKPDEVPERHNLSFFPTVNDIKNHIHEVQKSLQTGDVVYNSEIIPATLQWTTDSGNILRETVTVTFAEGNLLKEPITSKMGTSQTQTSLSPEPLPLLSPLSSFQPKIFTHLQALKLQPRLSSPDGSQALVSVNSHPSSSPPGLDTAGNAEANNHSLLLGQSQNLGTDTCLPENSSTASPMGSLPESVQNLVAVDQLVGGEDAEDAGNLEGNVKRTLLGDAHTIPIHILDSHPALVEEDTLSMNQVKQEPNEPTLSTEAKTLLDCKNVSAT
What is the function of this protein?
Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription.  Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence.
What are the official names of this protein?
Calcium-responsive transcription factor, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein, Calcium-response factor, CaRF.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSBA_XANAC
Sequence: MTISIDRPAPVSSWRTYRRLLAFAKPYRLLLVAALIAALIEAAGTTGFLALMKPITDETFIYKNAEVSRWLPVQIILLFVVRGVAGYITDMAMGKSARSIARDLRIKVMAKYLRLPGSRFDSEPVPSMLIRLGSDSDQVAQAAVDAVKVMIQQSLQVIGALALMLWHSWQVTLTILVLAPVLAWVMDKVARRYRRISHSIQESGAQLLQAADQTLSSHQEVKIYGAQQTEMERYGALANRNLRLAMKVESTRGISTATVQMIGAIGLSALLFVAGAQALAGRLTAGDFVVLMTSMLTIIPGLKQLTNVQNMVQRGLASAERLFSVLDSPDEPDQGTVPLTRAKGLIEFRDVTARYPGQVNPALADVSFVAQPGTVTAIVGRSGSGKSSLIKLIPRFYEAEAGQILLDGHPVQAYALADLRRQIALVGQQVMLFDGSIADNVAFGEMRNADAGKLERAILGANAMEFVAQLPEGLQSHVGTKGGRLSGGQRQRLAIARAMLKDAPVLILDEATAALDNESERLVQDALHKLMPDRTTLVIAHRLSTIEHADQVLVMDQGRIVERGTHHQLLAQGGLYSHLHGMQFRERQA
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RLMC_SALA4
Sequence: MQCALYDAGRCRSCQWITQSVNEQLSAKTADLHRLLAGLPVEQWCAPTGGPEQRFRNKAKMVVSGSVEKPLFGMLHRDGTPVDLCGCPLYPASFAPVFSALKPFIARAGLTPYNVARKRGELKYLLLTESQFDGGMMLRFVLRSETKLTQLRAALPWLRAQLPQLKVITANIQPVHMAIMEGETEIYLTDQQALAERFNDVPLWIRPQSFFQTNPTVASRLYATARDWVGQLPVRHMWDLFCGVGGFGLHCATPQMQLTGIEIAPEAIACAKQSAAELGLTRLHFQALDSTQFATAQGETPDLVLVNPPRRGIGKPLCDYLAQMAPRFIIYSSCNAQTMAQDIRHLPNYRIQRVQLFDMFPHTAHYEVLTLLCRL
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: GSX2_HUMAN
Sequence: MSRSFYVDSLIIKDTSRPAPSLPEPHPGPDFFIPLGMPPPLVMSVSGPGCPSRKSGAFCVCPLCVTSHLHSSRGSVGAGSGGAGAGVTGAGGSGVAGAAGALPLLKGQFSSAPGDAQFCPRVNHAHHHHHPPQHHHHHHQPQQPGSAAAAAAAAAAAAAAAALGHPQHHAPVCTATTYNVADPRRFHCLTMGGSDASQVPNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGTQRNSHAGCKCVGSQVHYARSEDEDSLSPASANDDKEISPL
What is the function of this protein?
Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed:31412107).  During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates.  At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons.  At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity).
What are the official names of this protein?
GS homeobox 2, Genetic-screened homeobox 2, Homeobox protein GSH-2.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: HXD4_CHICK
Sequence: MAMSSYMVNSYVDPKFPPCEEYLQSSYLGEQGAEYYGASQGSDFQHQGLYPRSNYSEQPFWLAGAQGSAVQPRGHGQEQSAPPSHFPGQAEHCPPPPCPIPSCGQQPALKAPHGSAVKQPAVVYPWMKKVHVNSVNPNYSGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSASNPHLQTVPKDHQTDLTTL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Binds to sites in the 5'-flanking sequence of its coding region with various affinities.  The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
What are the official names of this protein?
Homeobox protein Hox-D4, Homeobox protein Hox-A, Chox-A.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: KATG_METPP
Sequence: MATESKCPFNHAAGGGTTNQDWWPSQLRLELLNQHSSKSDPLGAGFDYAEEFKKLDYFALKKDLLALMTDSQDWWPADFGHYGPQFVRMAWHAAGTYRTADGRGGGGRGQQRFAPLNSWPDNVNIDKSRRLLWPIKQKYGQRISWADLLILTGNVALESMGFRTFGFAGGREDVWEPDNDVNWGNETTWLATDKRFTGDRDLDQPLAATHMGLIYVNPEGPNASGDPLAAAKDIRATFGRMAMDDEEIVALIAGGHTFGKAHGAAPESHKGPEPEGAPLEAQGLGWTSSFGSGHGKDTVSSGLEVTWTTTPARWSNDFFEHLFKFEWELTQSPAGAKQWTAKDAPEIIPDAHVPGKKLKPTMLTTDLTLRVDPEFEKISRRFLDNPQGFADAFARAWFKLTHRDMGPKVRYLGPEVPKEELLWQDPLPPATLPAPNAADVAELKAKIAASGLTVAQLVATAWASASTFRGGDKRGGANGARLRLAPQKDWEANTPGELAKVLATLETLQKASGKFSLADVIVLAGGVGVEQAAKAAGVGIEVPFAPGRVDATQEQTDVESFAFLEPVADGFRNYFKGPGSVPVEHLLVDKAQLLTLTAPEMTVLVGGLRVLGANAGGSRHGVFTDRPGVLTPDFFVNLLDMRTTWQPANGVYEGKDRQTGQQKWTATRVDLAFGSNAVLRALAEVYASADGQTKFVHDFVAAWTKVMNLDRYDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: Y2871_KLEP3
Sequence: MNMTLNKRWCLTAILALSAVVYTSSSFAATDRLVIESGDSAQSRQQASMEKEQWNDTRSLRQKVNKRAEKEWDKTDVAFDAQDNCQKSANVNAYWEPNTLRCLDRRTGRAINP
What are the official names of this protein?
UPF0482 protein KPK_2871.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.