Protein: ALBA_ASPBC
Sequence: MEGPSRVYLFGDQTSDIEAGLRRLLQAKNSTIVQSFFQQCFHAIRQEIAKLPPSQRKLFPRFTSIVDLLSKSRESGPSPVLESALTCIYQLGCFIHYYGDLGHGYPTPSNSHLVGLCLGVLSCTAVSCAKNVGELIPAAVEAVVVALRLGICVFRVRELVDSGDSESTCWSALISGISETEASRLIDEYSNKKATPPSSKPYISAVSSNGVTVSAPPTVLDEFIGTCISKNYKPVKAPIHGPYHAPHLYDNKDIERILQQSSALESLTASSPTVPVISSNTGKPINAKSTRDLFKVALEEILLRRLCWDKVTESCTSVCKTGTNHSCKLFPISSSATQSLFTALKKAGVNISLETGVGEIATNPDMRNLTGKAECSKIAIIGMSGRFPDADGTESFWDLLYKGLDVHRKVPADRWDVDAHVDLTGSKRNTSKVPYGCWINEPGLFDPRFFNMSPREALQADPAQRLALLTAYEALEMAGFIPDSSPSTQRDRVGIFYGMTSDDYREINSGQDIDTYFIPGGNRAFTPGRINYYFKFSGPSVSVDTACSSSLAAIHMACNSIWRNDCDAAITGGVNILTNPDNHAGLDRGHFLSTTGNCNTFDDGADGYCRADGVGSIVLKRLEDAEADNDPILAVINGAYTNHSAEAVSITRPHVGAQAFIFNKLLNDANIDPKEVSYVEMHGTGTQAGDAVEMQSVLDVFAPDYRRGPGQSLHIGSAKANIGHGESASGVTALVKVLLMMRENMIPPHCGIKTKINHNFPTDLAKRNVHIAFQPTPWNRPASGKRRSFVNNFSAAGGNTAILLEDAPIPERQGQDPRAFHLVSVSARSQSALKNNIESLVKYIDSQGKSFGVKETEFLPNLAYTTTARRIHHPFRVTAVGANLQSLRDSLHGALHRETYTPVPSTAPGIGFVFTGQGAQYTGMGKELYSTCFQFRTTIEHFDCIARSQGLPSILPLVDGSVPVEDLSPVVVQVGTTCVQMALVNYWTALGVKPAFIIGHSLGDYAALNTAGVLSTSDTIYLCGRRAQLLTKECKIGTHSMLAIKASLAEVKQFLKDELHEVSCVNAPAETVVSGLVADIDDLAQKCSTEGLKSTKLRVPYAFHSSQVDPILDTFEEIAQGVTFHKPTTPFVSALFGEVITDANWECLGPKYLRDHCRKTVNFLGGVEATRHAKLTNDKTLWVEIGSHTICSGMIKATLGPQVTTVASLRREEDTWKVLSNSLSSLHLAGIDINWKQYHQDFSSSHQVLRLPSYKWDLKNYWIPYTNNFCLHKGAPVAAVAAGPQHEFLTTAAQKVIETRSDGATATVVVENDIADPDLNRVIQGHKVNGAALCPSSLYADISQTLAEYLIKKYKPEYDGLGLDVCEVTVPRPLIAKSGQQLFRVSATADWAEKKVTLQVYSVTAEGKKTADHATCTVRFFDCAAAEAEWKRVSYLVKRSIDRLHDIAENGDAHRLGRGMVYKLFAALVDYDDNFKSIREVILDSEQHEATARVKFQAPQGNFHRNPFWIDSFGHLSGFIMNASDATDSKNQVFVNHGWDSMRCLKKFSPDVTYRTYVRMQPWKDSIWAGDVYVFDGDDIVAVYGAVKFQGLSRKILDTVLPPVGASKGPARPAASAQKAAPAATSKSRASAPAPAKAVAKPSAPSLVKRALTILAEEVGLSESELTDELVFADYGVDSLLSLTVTGRYREELDIDLESSVFIDQPTVKDFKQFLAPMSQGEASDGSTSDPESSSSFNGGSSTDESSAGSPVSSPPNEKIEQHATMKEIRAILADEIGVSEEELKDDENLGEMGMDSLLSLTVLGRIRETLDLDLPGEFFIENQTLNDVEDALGLKPKVAPAPAPTPAPAPVSAPILSEPVPNPKSTIMTRASPHPRSTSILLQGNPKTATKTLFLFPDGSGSATSYATIPGVSPDVCVYGLNCPYMKTPEKLKYPLAEMTFPYLAEIRRRQPKGPYNFGGWSAGGICAYDAARYLILEEGERVDRLLLLDSPFPIGLEKLPTRLYGFINSKGLFGEGNKAPPSWLLPHFLAFIDSLDTYRAVPLPFDDPKWANKMPKTFLVWAKDGICNKPDDPWPEPDPDGKPDTREMVWLLKNRTDMGPNKWDTLVGPANVGGISVIEGANHFTMTLGPKAKELGSFIGNAMAN
What is the function of this protein?
Non-reducing polyketide synthase involved in the biosynthesis of bifonsecin B, a dimeric gamma-naphthopyrone (PubMed:31067027).  The first step in the biosynthesis of bifonsecin B is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase albA, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:31067027).  YWA1 is then methylated by bfoE at position C-6 to yield foncesin which is further methylated at position C-8 by bfoD to produce fonsecin B (Probable).  A key enzyme in the biosynthetic pathway is the cytochrome P450 monooxygenase bfoB which catalyzes the oxidative dimerization of fonsecin B to bifonsecin B (PubMed:31067027).  Bfob also catalyzes the oxidative dimerization of rubrofusarin B into nigerone (PubMed:31067027).  The stereoselectivity of bfoB is influenced by the two natural monomeric substrates; homodimerization of fonsecin B yields a stereochemically pure biaryl, M-foncerine B, while rubrofusarin B yields a mixture of enantiomers M- and P-nigerone (PubMed:31067027).
What are the official names of this protein?
Non-reducing polyketide synthase albA, NR-PKS albA.