PharMolix/UniProtQA huggingface dataset:
Protein: VE7_BPV5
Sequence: MVAGPACSKFLPQDPPPPSVTLVLHDLTQEEDEQDFVTLHAQYRPTFKDKTPRRPGYNPRAAPCHIQRLSARCSVFFVQVGCPCGQPLKIAVQSTPDCISQFEQLLRGPLDLLCPHCASRCYGR
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: CMPDT_HAEIN
Sequence: MALELSDIRQQITQIDRSLLKLLSERHRLAFDVVRSKEISQKSLRDVEREQQLLQELVQFAENENYQLEAQYITSIFQKIIEDSVLTQQVYLQNKLNEQRNQNLHIAFLGKRGSYSNLAARNYAARYQKQFVELGCQSFEQVFEKVQTGEADFGVLPLENTTSGAINEVYDLLQHTDLSLVGELAYPIKHCVLVNDKTDLNQIDTLYSHPQVIQQCSQFIHSLDRVHIEYCESSSHAMQLVASLNKPNIAALGNEDGGKLYGLSVLKTNIANQENNITRFIVVAKEPREVSSQIPTKTLLLMTTSQQAGALVDALLVFKKHQINMTKLESRPIYGKPWEEMFYLEIEANIHHPDTKQALEELKNYSNYLKILGCYPSEIVKPVSV
What is the function of this protein?
Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
What are the official names of this protein?
Bifunctional chorismate mutase/prephenate dehydratase, Chorismate mutase-prephenate dehydratase, P-protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_PROMM
Sequence: MSLWVVKVGTSLLRGNEKQSTAEVIESYSACLSASLKRGDHVVLVTSGAVGLGCNRLGLSQRPVDVVALQGTAAIGQGQLMALYEAAMSRRGHTVAQVLLTRSDLGSRQRYRNASSTLKQLLDWGVLPVVNENDALSPEELRYGDNDTLSALVATAVEADQLIMLTDVDRLYSSDPRINASAEPISDVYHPHELTALEVAAGEGGAWGTGGMTTKLAAARIATASGITVLLADGRDPQVLDGLLQGRRSGTVFHPHPQPLGNRKSWLAHALKPLGTLQLDEGACDALQHRGASLLLVGVKEVEGNFEANQPVRLINPEGNELARGLCSLSSKELREAIETQMSTNRSPVVVHRDVLVLRNA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_CUPNH
Sequence: MNYPHPLIAREGWPFLAGAFVISLLVHASAGFWWALPLWIITVFVLQFFRDPPRPIPSQPNAVLAPADGRIVVVEKTQDPYAGREALKISVFMNVFNVHSNRVSVDGAVEKVEYFPGKFVNADMDKASVENERNAVLIRRAADGQLVTLVQVAGLVARRILCYTKVGDNLSRGQRYGFIRFGSRVDVYLPLDARPRVTIGEKVSASSTILAELDVK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MNMC_METPP
Sequence: MKTAPITPGRLAFSPDGVPLAPEFGDVYHPAAGALQQAHHVFLGGNRLPARWGGRGRFVILETGFGLGNNFLATWDAWQRDPQRCERLVFVSIEKHPLTREDLARAHAASPLPELARALVSAWPLSTPNLHPIAFEGGRVQLLLGFGDVALLLPQLVVSVDAFFLDGFAPARNPEMWEPRRLQRLGRLAAPGATAATWSAARVVRDGLSAAGFTVETTAGTGGKRDITVARFTPRHIAVPPPGGWHAHDAASREALVIGAGLAGCAAAWALSQQGWQCQLLDRAAEPADVTSGNPAGLFHGSFHRDDGPHARTLRAAALATERLAGAWIAQGRVSGQLAGCLRLESRWSDDAARAAMAAQQIAPGYIDWMDRAVASTLSGLALPSGAWFYPGGGWLAPRDYARELLARSGSLFRGGIDVATIERHSGLWRVLDEQRQVIAEAPVLVLANGLGANGLLASGRGEVPWPLTAVRGQISSLATDGHPATLPCPRLPVAGGGYVLPQTGGRLLFGATSQPDDIDPALRDADHRFNLQQLAGLSGCDVEAWSSLPWQGRVGWRAVTSDRLPLIGAVPDLEALDRTSRADQPRFVPRQRDARGGLYVFTGLGSRGITWAALGGQLLASWISGAPCPLEADLRDALDPARYALPRWRSDS
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLOA_BACFN
Sequence: MNVEPMYLTIFLIAGGIIFLVLFFHYVPFFLWLSAKVSGVNISLVQLFLMRIRNVPPYIIVPGMIEAHKAGLSNITRDELEAHYLAGGHVERVVHALVSASKANIELPFQMATAIDLAGRDVFEAVQMSVNPKVIDTPPVTAVAKDGIQLIAKARVTVRANIRQLVGGAGEDTILARVGEGIVSSIGSSENHKSVLENPDSISKLVLRKGLDAGTAFEILSIDIADIDIGKNIGAALQIDQANADKNIAQAKAEERRAMAVATEQEMKAKAEEARANVIQAEAEVPKAMAEAFRSGNLGIMDYYKMKNIQADTSMRENIAKPIGGATSKPLSD
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Membrane raft; Single-pass membrane protein.
Protein: DSP3_ARATH
Sequence: MCLIMETDDHNGDVLAPPSNFSMVEDGIYRSGFPRPENFSFLKTLNLRSIIYLCPEPYPEENLKFLEANNIKLYQFGIEGKTDPPTPMPKDTVLDALKVLVDVRNHPILIHCKRGKHRTGCLVGCLRKVQSWCLSSVLEEYQKNAGLKWRQRDLNFIEAFDIVSLRQCLLSIMYQYHGYGFKRRRLAYEEENVKTPKPQAARV
What is the function of this protein?
Possesses phosphotyrosine phosphatase activity in vitro (PubMed:21409566).  Hydrolyzes para-nitrophenyl phosphate in vitro (PubMed:17976645, PubMed:21409566).  Hydrolyzes O-methylfluorescein phosphate in vitro.  Dephosphorylates the phosphoinositides PI(3,5)P2 (PubMed:21409566).
What are the official names of this protein?
Tyrosine-protein phosphatase DSP3, Protein PLANT AND FUNGI ATYPICAL DUAL-SPECIFICITY PHOSPHATASE 3, AtPFA-DSP3.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FA20A_HUMAN
Sequence: MPGLRRDRLLTLLLLGALLSADLYFHLWPQVQRQLRPRERPRGCPCTGRASSLARDSAAAASDPGTIVHNFSRTEPRTEPAGGSHSGSSSKLQALFAHPLYNVPEEPPLLGAEDSLLASQEALRYYRRKVARWNRRHKMYREQMNLTSLDPPLQLRLEASWVQFHLGINRHGLYSRSSPVVSKLLQDMRHFPTISADYSQDEKALLGACDCTQIVKPSGVHLKLVLRFSDFGKAMFKPMRQQRDEETPVDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRIVNVTKEILEVTKNEILQSVFFVSPASNVCFFAKCPYMCKTEYAVCGNPHLLEGSLSAFLPSLNLAPRLSVPNPWIRSYTLAGKEEWEVNPLYCDTVKQIYPYNNSQRLLNVIDMAIFDFLIGNMDRHHYEMFTKFGDDGFLIHLDNARGFGRHSHDEISILSPLSQCCMIKKKTLLHLQLLAQADYRLSDVMRESLLEDQLSPVLTEPHLLALDRRLQTILRTVEGCIVAHGQQSVIVDGPVEQLAPDSGQANLTS
What is the function of this protein?
Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth.  Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.
What are the official names of this protein?
Pseudokinase FAM20A.
What is the protein family that this protein belongs to?
Belongs to the FAM20 family.
What are the subcellular locations of this protein?
Secreted. Golgi apparatus. Endoplasmic reticulum.
Protein: RL17_STRGG
Sequence: MPRPAKGARLGGSAAHEKLLLANLAKSLFEHGRITTTEAKARRLRPVAERLVTKAKKGDIHNRRLVLQTITDKSVVHTLFTEIAPRYENRPGGYTRITKIGNRRGDNAPMAVIELVEALTVAQQATGEAEAATKRAVKEDALKKDEAPAAESVEDAKPAEDAPAAEAADDKGKDA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: MDH_SALPK
Sequence: MKVAVLGAAGGIGQALALLLKNQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKNLVQQIAKTCPKACVGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKLPTEVEVPVIGGHSGVTILPLLSQIPGVSFTEQEAAELTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEKGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQHSLDAMLDTLKKDIQLGEDFINK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: SYR_METRJ
Sequence: MNIFALFEARVRDAVEALTRAGHLPEGLDLGRVVVEPPRDASHGDLATNAALVLAKEARANPKALGESLAAELRADPRIVEASVAGPGFINLRLDPAIFHAVVRDALEAPEAFGRARLPGGPINVEYVSANPTGPMHVGHGRGAVFGDALCNLLVAAGRQVTREYYINDAGVQVDVLARSAFQRYREALGEPFAIAEGLYPGDYLKPVGARLAETHGRALLDKPEAEWLPTVRETALGMMMDMIRADLAAIGIRHDVFFSERTLQESGAVKALLAELRAKGLVYEGRLPPPKGQLPEDWEDREQTLFRTKEFGDDSDRPLLKSDGSYTYFASDIAYHRAKYLAGATELIDVLGADHGGYVKRMQAAVKAVSDGKATLDVKLCQLVRLLRAGEPVKMSKRAGEFVTLRDVIDEVGRDAIRFMMLYRKNDATLDFDLAKVVEQSKDNPVFYVQYAHARVRSVQRQAREAFPDADLSVAALAREADLAVLSDPGEIEMMRLIAQYPRVLESAALAHEPHRIAFHLYELASALHSFWNKGKDLPQLRFVNATDRKSTWARLALVEALRSTLAAGLAILGVTAPDEMR
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG66_BPML5
Sequence: MSNTWFTSDLHIGHKRLMEIRNLADDVEEHDATLAKAWDSVVGKDDTVWILGDISSGSTKGQIHALGWISDRPGRKRLILGNHDGPHPMNRDAHKLVGAYWMVFEHVSTAARIRVPLYGDAGGHTDVLLSHFPYVGDHTSEDRHTQWRLRDDGKILIHGHTHSPMILSRHIHRRQIHVGIDAWGRLVSRDEIYDLVNHIHEEEGVHT
What are the official names of this protein?
Gene 66 protein, Gp66.
Protein: HPR_BACCN
Sequence: MKSGEKDYSIKEAMIFSQRIAQLSKALWKSVEKDWQQWIKPYDLNINEHHILSIAYHLEGASISEIAKFGVMHVSTAFNFSKKLEERGYLVFSKKEDDKRNTYIEITEKGEELLLKLMEEYNPENNSVFNGALALRNFYGKFPENIELIAILRNIYGQDFIDIFEKSLENIEENFTEQEQKLVKK
What is the function of this protein?
Negative regulator of protease production and sporulation.
What are the official names of this protein?
HTH-type transcriptional regulator Hpr, Protease production regulatory protein Hpr.
Protein: PTF1A_DANRE
Sequence: MDTVLDPFTGLDSFSSSYFDDDDFFTDHSSRDHLDTDDFLDEDVDFLTNQIQEYYKDSRISQDGDYCDVGNFSFSSSSSTFSYGCADSTSELSPHRDGGLLKRRRRMRSEVEMQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLAELVQSDMPIRNPHSDALNQPKKVIICHRGTRSPSPNDPDYGLPPLAGHSLSWTDEKQLKDQNIIRTAKVWTPEDPRKLHLKSSINNIENEPPFNFIS
What is the function of this protein?
Transcription factor implicated in the cell fate determination in various organs.  Binds to the E-box consensus sequence 5'-CANNTG-3'.  Required for exocrine pancreatic development.  Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
What are the official names of this protein?
Pancreas transcription factor 1 subunit alpha, Pancreas-specific transcription factor 1a, bHLH transcription factor p48.
What are the subcellular locations of this protein?
Nucleus.
Protein: YO387_YEAST
Sequence: MSFLNIFTFFSVLVSVATAVRFDLTNVTCNNLHGPHCGTYVMEVVGQNGTFLGQSTFAGADVLTESAGDAWARYLGQETRFLPKLTTIASNDTKNFSPLIFTTNIYTCNPQSIGDAMVPFANTVTGEIEYNSWADTADNASFITGLANQLFNSTQYGVQVASCYPNFASVILSTPTVNIFAANETLPDYCTAIQLKAVCPPDAGFA
What are the official names of this protein?
VEL1-related protein YOR387C.
What is the protein family that this protein belongs to?
Belongs to the VEL1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MOC2B_DROSI
Sequence: MDHVKLVNDPIDIAHIHQLLADEGCGASSVFVGTTRDNFQGKKVLSLAYEAYDSMALKEMNKICSDLRSKWLDLKHIVIYHRLGTVPVCEASVVIAASSPHRSEALESVSFAIDQLKTRVPIWKKEIYEGDNDGEWKENKESIRPKKSKSGFNYAACPCKVEESHDVPRTLVQIRVNDAELTKRLECFVNRKRDEINSQNVIDFKSSFVSSDKDLSDSCARTQSTIIKQEQSNCHLKVRRVNNRCGPQQMEMRPNYELELNKLMGSRDGQTDPIKEMRKSLPNSRLQAIESYMGLTTDNEENIFSRIKRVENRLLQLESISPEYRHFTKREPSSMEAAPPKKIRKKSYSAQELSAFIQKIKDGSEFS
What is the function of this protein?
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin.  Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated Mocs2A into precursor Z to generate a dithiolene group.
What are the official names of this protein?
Molybdopterin synthase catalytic subunit, Molybdenum cofactor synthesis protein 2 large subunit, Molybdenum cofactor synthesis protein 2B, MOCS2B.
What is the protein family that this protein belongs to?
Belongs to the MoaE family. MOCS2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDBH1_TITSE
Sequence: MKMMIPVIFSILLLIFSLSSTAMSLEDEQENMEERAEIDFSGIPEDIIKQIKETNAKPPARFDPAAFEKSDD
What is the function of this protein?
Agonist of the B2 bradykinin receptor (BDKRB2) (PubMed:18445483, PubMed:20417225).  Potentiates the hypotensive effect of bradykinin (BK) and induces a direct vasorelaxing effect independent of BK, by endothelium- and nitric oxide (NO)-dependent mechanisms in rat aortic ring preparations (PubMed:18445483, PubMed:20417225).  Also exerts proangiogenic, antiinflammatory, and antifibrogenic activities (PubMed:27732900).
What are the official names of this protein?
Hypotensin-1, Anti-hypertensive peptide, Hypotensin I, TsHpt-I, Tityustoxin-14 1, Hypotensin toxin Ts14.1, Ts14 1.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS4_SALAR
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTYKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: YFCU_ECOLI
Sequence: MPDHSLFRLRILPWCIALAMSGSYSSVWAEDDIQFDSRFLELKGDTKIDLKRFSSQGYVEPGKYNLQVQLNKQPLAEEYDIYWYAGEDDVSKSYACLTPELVAQFGLKEDVAKNLQWSHDGKCLKPGQLEGVEIKADLSQSALVISLPQAYLEYTWPDWDPPSRWDDGISGIIADYSITAQTRHEENGGDDSNEISGNGTVGVNLGPWRMRADWQTNYQHTRSNDDDDEFGGDDTQKKWEWSRYYAWRALPSLKAKLALGEDYLNSDIFDGFNYVGGSVSTDDQMLPPNLRGYAPDISGVAHTTAKVTVSQMGRVIYETQVPAGPFRIQDLGDSVSGTLHIRIEEQNGQVQEYDISTASMPYLTRPGQVRYKIMMGRPQEWGHHVEGGFFSGAEASWGIANGWSLYGGALGDENYQSAALGVGRDLSTFGAVAFDVTHSHTKLDKDTAYGKGSLDGNSFRVSYSKDFDQLNSRVTFAGYRFSEENFMTMSEYLDASDSEMVRTGNDKEMYTATYNQNFRDAGVSVYLNYTRHTYWDREEQTNYNIMLSHYFNMGSIRNMSVSLTGYRYEYDNRADKGMYISLSMPWGDNSTVSYNGNYGSGTDSSQVGYFSRVDDATHYQLNIGTSDKHTSVDGYYSHDGSLAQVDLSANYHEGQYTSAGLSLQGGATLTTHGGALHRTQNMGGTRLLIDADGVADVPVEGNGAAVYTNMFGKAVVSDVNNYYRNQAYIDLNKLPENAEATQSVVQATLTEGAIGYRKFAVISGQKAMAVLRLQDGSHPPFGAEVKNDNEQTVGLVDDDGSVYLAGVKPGEHMSVFWSGVAHCDINLPDPLPADLFNGLLLPCQHKGNVAPVVPDDIKPVIQEQTQQVTPTDPPVSVSANQ
What is the function of this protein?
Part of the yfcOPQRSUV fimbrial operon.  Could contribute to adhesion to various surfaces in specific environmental niches.  Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.  Probably involved in the export and assembly of fimbrial subunits across the outer membrane.
What are the official names of this protein?
Putative outer membrane usher protein YfcU.
What is the protein family that this protein belongs to?
Belongs to the fimbrial export usher family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: TRMA_GLAP5
Sequence: MTLPIHQYPALLAKKAENLTALLAPFNAPELDVFASDTSHFRLRAEFRVWHDNGDLYHIMFDQATKQRYRVDQFPIASQLINRMMTVLLAEIKGNELLTRKLFQIDYLSTLSGQIAVSMLYHKSLTEEWIEQAKLLKQRLIGYGFDVQLIGRATKQKIALDCDYVEEALNVDGQIYRYRQVENSFTQPNGKMNIKMLEWARACTANSKGDLLELYCGNGNFSIALANQFRKVLATEISKSSVESAQYNIAVNGVDNLQIIRMSAEEFTEAMNGVRVFYRLRGIDLKQYDCNTIFVDPPRVGLDQATLEMVQGYEKILYISCNPHTLADNLKQLTQTHRIERCALFDQFPYTEHIESGVWLIRNNQVGEK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: RPOC2_NANDO
Sequence: MAERADLVFHNKAIDGTAMKRLISRLIDHFGMAYTSHILDQIKTLGFQQATATSISLGIDDLLTIPSKGWLVQDAEQQSLILEKHHHYGNVHAVEKLRQSIEIWYATSEYLRQEMNPNFRMTDPSNPVHIMSFSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGTLRGSSVSPRNGTITERIFIQTLIGRVLADDIYIGSRCIAIRNQDIGIGLVNRFITFRAQPISIRTPFTCKSTSWICRLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPSNGKIKFKEDLVHPTRTRHGHPAFLCYIDLYVTIEGQDIRHNVTIPPKSFLLVQNDQYVESEQVIAEIRAGTSTLNFKERVRKHIYSDSEGEMHWSTAVYHAPEYTYGNVHLLPKTSHLWILSGGPYRSSIVSFSLHKDQDQMNVHSLSAEQKSISNLLVTNNQVRHKFLSSEPSGKKGERILDYSGPNRIICNGHCNFIYPAILHENSYLLAKRRRNRFIIPFQYNQEQEKELITRSGISIEIPINGIFRRNSILAYFDDPRYRRNSSGITKYGTIEAHSIVKKEDLIEYRKRPKYQTKIDRFFFIPEEVHILPGSSSVMVRNNSIIGVNTRITFKTRSRVGGLVRVEKKKKKIELKIFSGDIHFPGETDKISWHSGILIPPGTGKKNSKESKNFKNWIYVQRITPTKKKYFVLVRPVVTYEIADGINLATLFPQDPLQERDNVQLRVVNYILYGNGKPIRGISHTNIQLVRTCLVLNWDQEKNGSSMEEVHASFVEVRVNNLIRDFIRMDLVKSPISYTRKRNAPAGSELILANGSDYTNLNPFYSKARIQQSLTQHQGTIRTLLNRNKECQSLIFLSSSNCFRIGPFKGLKYNNMTKKSNKRDSLLLIRNSLGPLGIVPKIANFSSFYYLITHNQILINKYLLLDNLKQTFQKLKYYLMDENGRIYNPDPCSNMILNPFNWNWYFLHHDYCEETSTIISLGQFFCENVCISKYGPHLKSGQVIIVHVDSLVIRSAKPYLATPGATVHGHYGEILYKGDTLVTFIYEKSRSGDITQGLPKVEQVLEVRSIDSISMNLEKRVEGWNERITRILGIPWGFLIGAELTIAQSRVSLVNKIQKVYRSQGVQIHNRHIEIIVRQITSKVLVSEDGMSNVFSPGELIGLLRAERTGRALEEAICYRAVLLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGMIPVGTGFKGLVHRSSQHSNISLEIQNTNLFEGGMRDILFHHRELFYSCIPKNFHDTSEQKFTGFIDS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COX2_TRYCR
Sequence: MSFILSFWMIFLIDSVIVLLSFVCFVCVWICVLLLSTVLFVTKINNIYCTWDFVSSKFVDTYWFVIGVMFIMCLLLRLCLLLYFGCLNFVSFDLCKVVGFQWYWVYFLFGETTIFSNLILESDYLVGDMRLLQCNHVLTLLSLVIYKLWVSAVDVIHSFTLASLGIKVDCIPGRCNEIILFASNNATIYGQCSELCGVLHGFMPIVICFI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TPIS_HISS2
Sequence: MARRPLVMGNWKLNGSKAFTKELITGLKDELNAVSGCDVAIAPPVMYLAEAEAALVSSDIALGTQNVDLNKQGAFTGDISTEMLKDFGVKYVIIGHSERRQYHHESDEFIAKKFGVLKDAGLVPVLCIGESEAENEAGKTEEVCARQIDAVMNTLGVEAFNGAVIAYEPIWAIGTGKSATPAQAQAVHAFIRGHIAKQSQAVAERVIIQYGGSINDANAAELFTQPDIDGALVGGASLKASAFAVIVKAAAKAKN
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP5_IBDVP
Sequence: DANNRTGVHSGRHPGEAHSQVRDLDLQFDCGGHRVRANCLFPWIPWLNCGCSLHTAEQWELQVRSDAPDCPEPTGQLQLLQASESESHSEVKHTSWWRLCTKRHHKRRDLPRKPE
What is the function of this protein?
Plays a role in the release of virion progenies by disrupting the host plasma membrane.
What are the official names of this protein?
Protein VP5.
What is the protein family that this protein belongs to?
Belongs to the avibirnavirus/aquabirnavirus VP5 protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RHAD_ENT38
Sequence: MQTITNAWFVQGMIKATTDAWLKGWDERNGGNLTLRLDNADIAPFEADFHQKPRYIALSQPMPLLANTAFIVTGSGKFFRNVQLDPTANLGVVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATDGKDRVIMHCHATNLIALTYVLENDSAFITRKLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQDMQKHSLVLWPFHGVFGSGPTLDEAFGLIDTAEKSAEVLVKVYSMGGMKQTITQEELIALGKRFGVTPMKSALELYK
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_SHEHH
Sequence: MEVLAKHRFARTSPQKCRLVADQIRGLPVAKALEILTFSPKKAAVLVKKVLDSAIANAEHNEGADIDELRVGAIMIDEGPTMKRIMPRAKGRADRIIKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: GALL1_DROME
Sequence: MLSYIKRKLSESDSGVSSVATVTSSCGGDSGRAGGTGSSESGTGSSSASISGRSQNADELVRKTSQMSMDDEAIAFGEDALLHELGYKNQTELQETIYDLLRGIRDPEKPCTLEDLNVVYEDGIFVMPPTRSNVSVVRIEFNPTVPHCSLATLIGLCIRVKVERGLPHNIKLDIYIKKGAHQTEEEINKQINDKERIAAAMENPNLRDLVENCIKDEE
What is the function of this protein?
Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos.  The CGX complex is also required for cell proliferation in developing wing disks.  In the CGX complex, acts with crb to recruit Xpd thus forming the functional complex.
What are the official names of this protein?
MIP18 family protein galla-1.
What is the protein family that this protein belongs to?
Belongs to the MIP18 family.
What are the subcellular locations of this protein?
Apical cell membrane. Cytoplasm, cytoskeleton, spindle. Note=Expressed in a punctate pattern in spindle microtubules during metaphase.