PharMolix/UniProtQA huggingface dataset:
Protein: VPS54_YEAST
Sequence: MSISETPHNKSQGLQKAAGRPKIVVPEGSPSRNSDSGSFTIEGDTSLNDDLLSISGSVTPRARRSSRLSLDSITPRRSFDSRTLSVANSRSFGFENETHSGSMDFSPLGNNSIYEIVMNTRRKNWLNYPTVADIPQVSLSKNDLDDHWKTHVIEYVKNIKSDYQIFQSTNNIRNMNQMEQLKELREGENMHEESFEANLRQGDAELINSIPDFYFSDKFQLDNPRTFHKVLDAIDLFLTKLDMKRQAERDEAFSELRDRLNDFLDIVETLLVTEISKSSHKFFHALSEVDNIQKRALDTMSELKELAQNIKTIDAENIRKKISHLEMIFKRKNVEKLEQGLLQAKLVLNKTDECKSMYEENKLDNCLELIKSIDYLIKGDDSINEDVQSWTRCWPYKLSNLRTIPALSATREFLTNMKIEIGGKFSLQLSILLIDDLRSFCKSIKPKETLHRIQTGSNDKKQTIFTDNFSSKITELIVRLNRCEELTSAFDLYREKSITELKSIIKIYLPTENAHADNNHDEKHLNNGSTSGSKLSRLIKEQTPAEFQSMLVNIFTHALEALRRLYGHQKLLLDISLNELASVKSPNENQHNMITQLDIRTGINEIIRIIQLRTGKIIAVRRELNLSLRYDYFLKFYAICVIFIQECEVLSGEFLTKYLSNVLASQIKHYANAQSSKNYRNIKKKIDAEEWIPYIVDSSIQSDVNDIVSSIDIDPLSWTTILDMVGGSHDCENGRSEDKEKDEGNETYQGHRKSVVVGDKTFVASSSLLATIEVIKELMVLSINLPSIYLSNFEKLCYDALQYYNSSAMASVTQPGNSLLKTGRNLSIMGESLDCLAEFVIIVQRFYQRLSNSNRDFEPFDASHYTTLLGQFQASSNKIYMANAPPPPV
What is the function of this protein?
Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles.  Seems also to be involved in protein transport from Golgi to the plasma membrane and is required for the integrity of the actin cytoskeleton.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 54, CPF1 genetically-interacting protein 1, Temperature-sensitive clathrin synthetic mutation protein 3.
What is the protein family that this protein belongs to?
Belongs to the VPS54 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Note=May also be mitochondrial.
Protein: RL28_POLSJ
Sequence: MARVCQVTGKGPMVGNNVSHANNKTKRRFMPNLQYRRFWVESENRWVRLRITSAGLRLIDKKGIDAILVDLRARGEI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: HSP1_TRIVU
Sequence: MARYRHSRSRSRSRYRRRRRRRRSRYRSRRRRYRRSRRRRRRGRRRRGYSRRRYSRRGRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MNME_THET2
Sequence: MRALRDPICAIATPLGKGAIGVVRLSGEGALEIAARVWRGKDPRRLKGGRFTLGEVVDPKTGEAIDQALLLVFRAPRSYTGEDLVEFQTHGSLAVLRRVMEVLVAEGARPAGRGEFTFRAYMNGKLDLAQAEAVLALIEAEGELARRQALRALEGALSRRIEALENRLLDLLAHIQALLDYPEEGVEPLEAERTLREVLAEVEALLAQAKASRLAQKGARLALIGAPNAGKSSLLNALLGYERALVSPIPGTTRDYLEAPLELFGIPLVAVDTAGVRETEDPVERMGVERALRIAEEADLVLYVVDRSQPKPAPPPLPWARTLKVATKSDLPPAWEDPEFLPVSSLTGEGLGRLKEALREALLGREGGEVLLTERQVEALLRARERLEEALALPEDLMGLALEEAARALALLTGKEVAEEVVARVFQNFCVGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSX1_PROCO
Sequence: MTSLPLGVKVEDSAFGKSAGGGAGQASSAAAATAATMGADEEGAKPKVSPSLLPFSVEALMADHRKPGAKESVLAASEGAQAAGGSAQPLGVRPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALIKAESPEKPERTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYGASGPFQRAALPVAPVGLYTAHVGYSMYHLT
What is the function of this protein?
Acts as a transcriptional repressor.  May play a role in limb-pattern formation.  Acts in cranofacial development and specifically in odontogenesis (By similarity).
What are the official names of this protein?
Homeobox protein MSX-1, Msh homeobox 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the Msh homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU1M_SAGOE
Sequence: MFMINLLVVILSALVAMAFLTLTERKVLGYMQFRKGPNIVGPYGTLQPIADAMKLFTKEPLLPTSSTSTLYLIAPTLALSISLLLWTPLPMPYPLMNFNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFNLQSLITTQEHSWLLFPSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNIEYAAGSFALFFMAEYMNIIMMNALTTTIFLAAPHNTAAPETYTINFMTKTLLLTTLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLALCMWYISMPTLTSGIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MENG_SYNY3
Sequence: MSNSLLTQPTQESVQQIFARIAPQYDDLNTFLSFGQHHIWKAMAVKWSGVSPGDRLLDVCCGSGDLAFQGAKVVGTRGKVVGLDFCAELLAIAAGKHKSKYAHLPMQWLQGDALALPFSDNEFDGATMGYGLRNVGNIPQALTELQRVLKPGKKVAILDFHQPGNALAANFQRWYLANVVVPMAKQWRLTEEYAYLQPSLDRFPTGPKQVQFALEVGFAKAVHYPIAAGLMGVLVAEK
What is the function of this protein?
Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol.
What are the official names of this protein?
2-phytyl-1,4-naphtoquinone methyltransferase, Demethylphylloquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: KEFC_KLEAE
Sequence: MDSHTLIQALIYLGAAALIVPIASVLGLGSVLGYLIAGCIIGPWALRLVNDAEAILHFAEIGVVLMLVAMGLELDPQRLWKLRASVFDGGALQMVACGVLIGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQMGRSAFAVLLFQDIAAIPLVAMIPLLAASGGATSLMAFALSALKVAAALALVVVLGRYLTRPLLRFVARSGLREVFSAVACSWSSALGLLLEEVGLSMAMGAFLAGVLLASSEYRHALENDIEPVKGLLLGLFFIGVGMSIDFAPWSPNPLRIVILLVGFPAIKMLMLWLIAQPLGVPRAQHRWFAVLLGQGSEFAFVVFGPARMADVLDGEWPKALTLAVALSMATTPILLVLLTRLEKSSSGQARDADEIDEEQPRVIVAGFGRFGQIAGRLLLSSGVKMVILDHDPDHVDTLRKFDMKVFYGDATRVDLLESAGAEKAEVLINAIDDPHVSLELVARVKEHFPHLQIISRARDVDHYIQLRQAGVEAPERETFEAALKSGRMTLEALGLGAYEARERPDLFRRFNLQMVEEMVAMAENDPRRGVAVFKRTSDMLTGIINEDRHHLSLVQRHGWQGTEEGRHTGDIADEPENKPSA
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefC, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYGB_CITK8
Sequence: MSEKTFLVEIGTEELPPKALRSLAESFAANVTAELDNAGLAHGNVEWFAAPRRLALKVANLAASQPDREVEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLTTDKGEWLLYRAHVKGESAEALLPNMIATSLAKLPIPKLMRWGASDVHFVRPVHTVTLLLGDKLIPATILGIQSDRVIRGHRFMGEPEITIDTADQYPQILLERGKVVADYEARKAKIKADAEEAARQIGGNADLSESLLEEVTSLVEWPVVLTAKFEEKFLAVPSEALVYTMKGDQKYFPVYAADGKLLPNFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFNTDRKKRLEDNLPRLQTVLFQQQLGTLRDKTDRIQALAGWIAEQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLNLDLKTLTEEAARLYGDKLTNANVVDDVIDFMLGRFRAWYQDEGYTVDTIQAVLARRPTRPADFDARMKAVSHFRTLEEASALAAANKRVSNILAKSDEVLNDRVNAATLKEPEEIALALQVVVLRDKLEPVFAEGRYQEALVELAELREPVDTFFEKVMVMVDDKDLRINRLSMLAKLRELFLQVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS_THEAC
Sequence: MRDIEEIIKEIGLGRDDYELYGRYMAKLDLGLQNRGRPRAKLILVTAMTPTPAGEGKTTTTIGLGQAMKKLGKNVAIAIREPSLGPCFGIKGGATGGGKSKVEPSDRINLFFTGDFPTITAAHNLLSAMINNHMYHGNELNLDPKRITFPRTIDMNDRSLRSILVGVGPRDMGVLAGDSFVITPASEVMAITGLSLNYQDLKARLSRILAGFTTKNKPVFAGDLKAEGSMAALLRDALKPNLVQTTEGVPAFVHTGPFGNIAHGTSSLVADKIALNLFDYVITEAGFGSDLGAEKFFNLASRIGDLPINAVVLVATIRAIKHHGGSKKEGEDIDAVKTGSKNLIRHVQNIRNFGIDPVVAVNRFPTDTDGEIRALGEILDSNGIKWALSEVFAKGGEGGIDLANKVLASLGSHEIKRTYDLKDDIRTKIEKIARNVYGADGVIFEKKALSDMKKAEEIMENPYVCMAKTQYSFSDDASLLNDPHGFTIKVQSINISSGAGFVVPILGEIMTMPGLPKHPAAENIDLTDSGEITGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: PLC_DICDI
Sequence: MDTLTNSQDYSNVDLSLESLAEELYNIQSFNKDVILDSFDIDDYDHTQLDTTIDFNKFKIGLTILKISSKGKPQKKKLIFDLARNQIVCGKKKKVNFSEIDEIRVGHKTNIFNQFKSSKNLKEDIESIQQSFSILFSGNLRKTMDFVCSDIPERRQIVSALYHVVQESKSVNNEYNFVKREWDRVGKDSIDFSTLKKILARLNFTTSDAVLHNLMKFSDSNSDYHLDFSEFSNLLKLLRSHPEMKPVFYKYNGGNGEWVPIQGMIDFFRIEQSEVWTVEQCRDLIKKYHHERLDCISFENFEEFICGEANLAQYPHTSTVYQDTSKPLSYYFINSSHNTYLSGHQLKGLSTSEMYTNTLRQGCKCVELDVWDGNDGDPIIFHGNTLTSQIKFSHVCETIKARGFETSPYPVILSLEVHCSVPQQIMMANHMKEIFGEMLPTPLPEGTKELPTLDSLKYKILLKGHTSHTHVSAVGNSSASSSQSNIQTDDNDDDGAVDLTEYDEVDDRSASSSSSSFSLSFGSSGKKKKITKIKIAPEFEELIYLVSHGFKSGNTTKEIPSYKIHSLVEEKVKQLVQSEPREVVEASQNHLLRVYPRGTRFDSSNFDPMPGWSIGCQLAALNQQTSSEPMWINDGMFSDNGGCGYVLKPPCLLPGECETYDPTSPERIKSSKYSRLIVNVISARQLPKYTKSTKGEVIDPYVTLSIVGTHFDQKVEKTKVIDNNGFNPHWGEEFEFPLYNSQLSMLLIRVDDKDKVGHNRIGHHCIRVENIRPGYRILKLKNNFNRTIPLANLLCKFTFVE
What is the function of this protein?
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, Phosphoinositide phospholipase C, PLC.
Protein: RS4_MESHJ
Sequence: MSRYTGSIFRKSRRLGFSILETGKEFAKGKQRRYAPGLHGLRRSKPSDYGVHLREKQKVRFMYGLSEKQFRNTYRKATKKTGIAGTLFLQALESRLDNSVYRAGFAETRRQARQLVNHGHFLVNNKKVDIPSFQLKQGDIFELTTRKDGKIRKNQQILTSLETRTPAAWLEVDKDNFKVVFNRMPERSELNQEIKESLIVEFYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: NPC2_SCHPO
Sequence: MRLTTFIYAITCLPIFISASSWFSSFSFGESKSTDLVSSTSEKIPGANPASYCADWDRGDDHVVVDYINLIPNPPAAGKNLTIETEINVGTTVLNGSYVDIQVKYGFVRIVNERLDICDKAYELAAVECPVEPGIITKQATISLPWAIPPGRYHVLATAYNADGEQLTCVSASVSFSHFGFQLINQDH
What is the function of this protein?
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
What are the official names of this protein?
Phosphatidylglycerol/phosphatidylinositol transfer protein, PG/PI-TP.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
Protein: PFKA2_ARATH
Sequence: MAAETSIRKLPSLSGLRHRRNPLEDNPYFHPSNGFYITPSDVILAQVAYDHSAHSQSRVAYHRAGPRREIMYEPSAVKAAIVTCGGLCPGMNTVIRELVVGLWELYGVREIYGIPAGYRGFYSMKAVKLDPKAVHDWHKKGGTVLATSRGGFHLQKIVDAIHLNGYNQVYIIGGDGTMRGAVEIFKEISLRKLEVGITVIPKTVDNDVGIIDRSFGFQTAVEMAQEAISAAHVEAESAVNGIGLVKLMGRSTGHIALHATLSSRDVDCCLIPEMDFYLEGKGGLFEFLEKRLKERGHAVLVVAEGAGQEMIPRNESQKQERDESGNAVFLDVGVWFKSVLKAWWEREHPDELFTVKYIDPTYMIRAVPANATDNLYCTLLAHSAIHGVMAGYTGFVPGPINGNYAYIPLEEVAQTKNQVNTRDHKWAWVRSVTNQPDFETNVKG
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase 2, ATP-PFK 2, Phosphofructokinase 2, Phosphohexokinase 2.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYLD_METAC
Sequence: MALLTPEDLENINRQLHEADSTVRRVTGLDIKGVCKDFYGTTPCCEKVGIVPVTSGNGIIGNFSESLRAITEYFGFDSFVTTMPDVSGYYEAVRNGAQIILMADDNTFLAHNLKNGKIANNQPCTGIIYAEIASRYMKADSKDVLAVGLGKVGFPGAAHLVNKGFRVYGYDADKALLEKTVSDLGITPFEPENPRRFSIIFEATPCADTVPESVISDNCVISTPGIPCAISRELQEKYGVELIMEPLGIGTASMLYSIL
What is the function of this protein?
Likely catalyzes the NAD(P)-dependent oxidative deamination of (3R)-3-methyl-D-ornithyl-N6-L-lysine, resulting in the formation of pyrrolysine after spontaneous dehydration and cyclization of the intermediate.  Is required for the biosynthesis of pyrrolysine.
What are the official names of this protein?
3-methylornithyl-N6-L-lysine dehydrogenase, (3R)-3-methyl-D-ornithyl-N6-L-lysine dehydrogenase, Pyrrolysine biosynthesis protein PylD.
What is the protein family that this protein belongs to?
Belongs to the PylD family.
Protein: RBL2_ARATH
Sequence: MANRDVERVGKKNRGANNNYFYEESSGETHWTSWLIPAIVVANLAVFIAVMFVNDCPKKITGPNKECVARFLGRFSFQPLKENPLFGPSSSTLEKMGALEWRKVVHEHQGWRLLSCMWLHAGIIHLLTNMLSLIFIGIRLEQQFGFIRVGLIYLISGLGGSILSSLFLQESISVGASGALFGLLGAMLSELLTNWTIYANKAAALITLLFIIAINLALGMLPRVDNFAHIGGFLTGFCLGFVLLVRPQYGWEASRTNTSRTKRKYSMYQYVLFVVSVVLLVVGLTVALVMLFKGENGNKHCKWCHYLSCFPTSKWTC
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.  Can cleave the Drosophila proteins Spitz and Keren (PubMed:16223493).  May function in pollen elongation (PubMed:22007993).
What are the official names of this protein?
RHOMBOID-like protein 2, AtRBL2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: ATPH_NANDO
Sequence: MNPLISAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL11_SYNE7
Sequence: MAKKVVALIKLALPAGKANPAPPVGPALGQHGVNIMAFCKEYNARTQDKVGLVIPVEISVFEDRSFTFILKTPPASVLIAKAAGIERGSGNPNKTKVGKITTAQLREIAETKLPDLNTKNVEAAMRIVEGTARNMGVTIAD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RL31_BACP2
Sequence: MKTGIHPNYKKATVKCACGNEFETGSVKEEVRIEICSECHPFYTGRQKFASADGRVDRFNKKYGLK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: Y2656_BURTA
Sequence: MADPQLITTAFDLPGYRIERSLGVARGIVVRSRSIVGTFGASIQTLFGGNISLYTSLCERARQDAYERMIEEARQMGGNAIVGMRYDATEIASGVTEVLCYGTAVQAVRAG
What are the official names of this protein?
UPF0145 protein BTH_I2656.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: CLE1A_CONCL
Sequence: MNVTAMFIVLLLTMPLTDGFNIRAINGGELFGLVQRDAGNALDHGFYRRGDCPPWCVGARCRAEKC
What is the function of this protein?
Probable neurotoxin with unknown target (Probable).  Possibly targets ion channels (Probable).  This peptide could be considered as an apoptosis activator in some cancers (tested on lung and breast cancer cell lines) (PubMed:26861394, PubMed:31861952, PubMed:33061442).  Provokes the decrease of H1299 lung cancer cells viability after 24 hours treatment, and induces a high Bax/Bcl-2 ratio, which suggests that this peptide can activate apoptosis in H1299 cells (PubMed:31861952).  In addition, H1299 and H1437 lung cancer cell lines treated with this peptide have decreased cell viability, activated caspases, and reduced expression of the pro-survival protein NF-kappa-B (NFKB1), indicating activation of apoptosis (PubMed:26861394).  In synergy with MicroRNA-101-3p, this synthetic peptide inhibits breast cancer cells (SK-BR-3 and MCF-7) migration, invasion, and proliferation through suppressing the expression of the methyltransferase EZH2 (PubMed:33061442).  In parallel, this synergy treatment is able to promote the apoptosis of breast cancer cells (PubMed:33061442).  Against microbes, this synthetic toxin (at micromolar concentrations) lowers viability and inhibits host cell invasion by the opportunistic parasite Toxoplasma gondii (tachyzoite form) (PubMed:27070627).  In addition, it permits T. gondii intracellular replication to decrease while viability of the host cell is unaffected (PubMed:27070627).
What are the official names of this protein?
Conotoxin Cl14.1a, Conotoxin Cal14.1a.
What is the protein family that this protein belongs to?
Belongs to the conotoxin L superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CRGA_MYCTO
Sequence: MPKSKVRKKNDFTVSAVSRTPMKVKVGPSSVWFVSLFIGLMLIGLIWLMVFQLAAIGSQAPTALNWMAQLGPWNYAIAFAFMITGLLLTMRWH
What is the function of this protein?
Involved in cell division.  Plays an important role in septal peptidoglycan synthesis and cell shape morphogenesis.  May facilitate the recruitment of the peptidoglycan synthesis machinery to poles and septal zones and coordinate peptidoglycan synthesis at these sites (By similarity).
What are the official names of this protein?
Cell division protein CrgA.
What is the protein family that this protein belongs to?
Belongs to the CrgA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to midcell sites in an FtsZ-dependent manner and colocalizes with FtsZ. Localizes at septa, at poles and on membranes (By similarity).
Protein: BGAL1_ENTCL
Sequence: MSDTPSLTLSALLARRDWENPVVTQWNRLAAHAPLHSWRNEPSARDDAGSARRQTLNGLWRFSYFTAPEQVPQAWVTEDCADAVAMPVPSNWQMQGFDTPIYTNVTYPIPVNPPFVPQENPTGCYSLTFEVDDAWLQSGQTRIIFDGVNSAFHLWCNGQWIGYSQDSRLPAEFDLSAALRPGQNRLAVMVLRWCDGSYLEDQDMWRMSGIFRDVTLLHKPETQIADYHVVTDLNAELDRAVLKVDVTLAGAGFADGEVVFTLWRKGEKCASVSRQPGSAIVDERGSWAERLTVTIPVETPALWSAETPELYRLTMALLNPQGEVLEIEACDVGFRRVEISNGLLKLNGKPLLIRGVNRHEHHSENGQVMDEATMRRDIETMKQHSFNAVRCSHYPNHPLWYQLCDRYGLYVVDEANIETHGMVPMSRLADDPRWLPAMSERVTRMVQRDRNHPSIIIWSLGNESGHGANHDALYRWLKTTDPTRPVQYEGGGANTAATDIVCPMYARVDRDQPFPAVPKWSIKKWIGMPDETRPLILCEYAHAMGNSFGGFAKYWQAFRSHPRLQGGFVWDWVDQALTKRDEDGNTFWAYGGDFGDKPNDRQFCLNGLVFPDRTPHPALYEAHGPQQFFTFTRVSTSPLVIEVQSGYLFRHTDNEVLNWTVARDGDVLVAGEVTLAMVPEGTQRLEIALPELNAGPGEVWLNVEVRQPRATPWSPAAIAAAGSSGRFRLRSLLLRQPRRRAAVLTQTDRILEIAHRQQRWQFDRASGNLTQWWRNGVETLLSPLTDNVSRAPLDNDIGVSEATKIDPNAWVERWKAAGMYDLTPRVLHCEAEQHAGEVVVTTQHVLEYRGKALFLSRKVWRIDEQGVLHGDIQVDMASDIPEPARIGLSVHLAETPENVRWLGLGPHENYPDRKLAAQQGRWTLPLEAMHTPYIFPTENGLRCDTRELVVGMHQLNGHFHFSVSRYSQQQLRETTHHHLLREEPGCWLNLDAFHMGVGGDDSWSPSVSPEFILQTRQLRYTFSWQQNP
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: Y3893_DECAR
Sequence: MDNVNLTDNFLIAMPTLEDPYFSNALVYICEHNENGALGIIVNRPIDMNLASLLEKIDIKLEAENLADMPVYFGGPVQLDRGFVLHRPIGQWQSTLAINSDVGLTSSRDVLSSVGSAGLPAEILVTLGYAGWDAGQLEEELAQNSWLTVPAKASILFDLPPEERLPAAMQKLGISFTQLSDVAGHA
What are the official names of this protein?
UPF0301 protein Daro_3893.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: NUOH_YERPN
Sequence: MSWFTPELIEILISVLKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWVPRFSDRAIFTLAPVIAFTSLLLSFAIVPVSPTWAVADLNIGILFFLMMAGLAVYAVLFAGWASNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMQDIVNSQEHVWNVIPQFFGFLTFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTVSALIVTLFFGGWQGPFLPPFIWFALKTAFFMVMFILIRASLPRPRYDQVMSFGWKVCLPLTLLNLLATAAVILYNAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CML1_MOUSE
Sequence: MEYDAYNDSGIYDDEYSDGFGYFVDLEEASPWEAKVAPVFLVVIYSLVCFLGLLGNGLVIVIATFKMKKTVNTVWFVNLAVADFLFNIFLPMHITYAAMDYHWVFGKAMCKISNFLLSHNMYTSVFLLTVISFDRCISVLLPVWSQNHRSIRLAYMTCSAVWVLAFFLSSPSLVFRDTANIHGKITCFNNFSLAAPESSPHPAHSQVVSTGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKLQRNRLAKNKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVPSSVFSLGLPLATAVAIANSCMNPILYVFMGHDFRKFKVALFSRLANALSEDTGPSSYPSHRSFTKMSSLNEKASVNEKETSTL
What is the function of this protein?
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1.  Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis.  Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity).  Positively regulates adipogenesis and adipocyte metabolism.
What are the official names of this protein?
Chemerin-like receptor 1, Chemokine-like receptor 1, G-protein coupled receptor DEZ.
What is the protein family that this protein belongs to?
Belongs to the chemokine-like receptor (CMKLR) family.
Protein: RL13_CLOD6
Sequence: MKSYIAKPADVQRKWYLVDAEGKTLGRLATEIATVLRGKHKPTFTPHVDGGDFVVVVNAEKIVLSGKKLDQKYYRYHTGYVGGLKEISYRDMMDKKPEEVISHAVSGMLPKNKLRSRMMTRLRVFAGAEHTHAAQNPEVLNFK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RK14_TOXGO
Sequence: MTQLNSFFYVSDNTGVKKIFSIQNITRNSFLVNTTDIILGIIKEISFKSSFKYSEIVYGFVVRLKKTQNIQNRYNYIFNENAVILIDKNFNPLGTRIFGLFPENLKNNNYLKLNSLVLNII
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, apicoplast.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, apicoplast.