PharMolix/UniProtQA huggingface dataset:
Protein: NUOA2_CHLT3
Sequence: MDYTISEFGKVFLFLLFGVVFVIGGYVSSRMLRPHRPNDEKLTSYECGEEAVGSAWVQFNIRFYVVALIFIIFDVEVLFLFPWATVFKQLGGFALFEAVIFVTILTLGLVYAWVKGDLDWVRPTPNVPKMPEKRFDNISSGRSQVVKEESVS
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A 2, NADH dehydrogenase I subunit A 2, NDH-1 subunit A 2, NUO1 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HBA_CANLF
Sequence: VLSPADKTNIKSTWDKIGGHAGDYGGEALDRTFQSFPTTKTYFPHFDLSPGSAQVKAHGKKVADALTTAVAHLDDLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLACHHPTEFTPAVHASLDKFFAAVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RLME_BURMA
Sequence: MAKNRFNQSWLHDHINDPYVKMAQREGYRARAAYKLKEIDEQDKLIRPGQVIVDLGAAPGSWSQYARNKLAQGKRRDAVREGGIDGTIIALDMLPMEPVADVHFIQGDFREESVLHQLEEVLAGRAVDLVISDMAPNLSGVAVADAARIEHVCDLALEFAQNHLKPDGALLVKCFHGSGYSQIVEKFKHQFKTVAPRKPKASRDKSSETFILGRHLKQPR
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_HALOH
Sequence: MIKQVEKNAKQKMEKVLEATKHDLNTVRTGRARPSLVENIMVDYYGTQTPIQQMAKVVAPEARQLVIEPWDKSVIESIEKAILKSNLGLNPSNDGNVIRINIPQLTEERRKELVKVAHEKAEKGRIAIRNIRREANDELKEMEKNSEISEDNYHRGLDMIQELTDTYIDKIDKMLEDKEQDIMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_GLOVI
Sequence: MYPAITPLQAGLQWWAVAGRQGVAELWQVQVETAADGADGEVEETLYWYLSELGLPHVERQILAGRLVLRGYLSGETPEGVMERWREHIRERLTQKAEIGWYAVERRDWQAAWREQWRPIFVGERLVIWPVWLPDPPGDRLVIPLDPGMAFGTGEHATTRLCLRALESVPDLGTFADVGCGSGVLTVAALKLGAGRGWAVDTDDLAVVSTRKNLEISGLEERVTVARGSTEQLSGPLDGVVSNILAEVIANLAPEFRRLVHPGGWGIFSGLLLTQAPRVVEALAGQGFALSETLSEGDWACLVGRFSADRPRSAGS
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_MALP2
Sequence: MKKYDCLVIGAGHAGLEAAFILAKKKYKVALFVLDKKLVGNMPCNPSIGGPAKGIVTREIDALGGMQAIAADNTQLQMKLLNSSKGAGTWALRAQIDKLEYSKWFLNRIEENEYIDLIDKEVNSIKFVNQKVCGVYTVDNQFFESNYLIVTTGTFLDSSIHIGHKVIKKGPDDFNGSYLLAKQIKELDFQTIRLKTGTPPRILKNSIDYSKLQIEPGTNKKYSFSHFDRKFLDFNKQEVCYLAFTNNKIHEIINNNLDKSAMYSGFITGTGPRYCPSIEDKVVRFNDKERHQLFVEPESKHLDTIYLGGLSSSLPEDVQEQIVKNIVGFENAVIKKYAYAIEYDAINPIQLYPTLETKKIKGLFFAGQINGTSGYEEAACQGLMAGINVLCQLENREPLVLKRNEAYIGVLIEDLINKEITDPYRLLTSRAEYRLELRNDNADQRLLKYGYELGLISQSHWDEYNKNLENFNNTLKELETSTLKNVKEFKYNSRKTNTTLYEILKRPDYSFIDMEPFLKNKNTLDEYWKDKVDIYIKYGGYIKSQQKIINDTKNIDNIKLSSISDYKDVPNISLEARDKLNKVKPLTLGQASRVSGINLVDLINIKLYLENKKKQT
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_KLEP3
Sequence: MLDNTRLRIAIQKSGRLSEDSRELLSRCGIKVNLHTQRLIALAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLSRRAQGEDPRYFTLRRLDFGGCRLSLATPVDEAWNGPAALDGKRIATSYPHLLKRYLDQKGISFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMADAKQQLIDRLLTRIQGVIQARESKYIMMHAPTERLEEVVALLPGAERPTILPLAGDKQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA1_CHICK
Sequence: MLPVAGSDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILYVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCKAMSIGARSQSARNYLERHMTEFTDCNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDMEFTIYDDDDVAPFLEGLEERPQRKPALPADEPAEKAEEPMEH
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit alpha type-1, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y1496_PSEF5
Sequence: MKRICSIYKSPRKNEMYLYVLKSEALERVPENLLLAFGKPQHAFDLVLSPERKLSREDIHQVLENLDKQGYHLQMPPAEDEYIEHLPEELLRRNDPV
What are the official names of this protein?
YcgL domain-containing protein PFL_1496.
Protein: RNPA_SHESM
Sequence: MTSYTFTRELRLLTPAQFKSVFSNPIKASSAEITLLAIPNSEQHPRLGLTVAKRYVKRANQRNRIKRVIRDSFRLNQHDIPHLDIVVLVRNGVMEMENAEINKLIEKLWRKLSRRYNG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL35_POLAQ
Sequence: MPKMKSKSSAKKRFTVRAGGTIKRGQAFKRHILTKKTTKNKRHLRGSTEVAKADVKSIRSMLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: KN14D_ARATH
Sequence: MPLRNQNRAPLPSPNVKKEALSSIPFDKRRKETQGTGRRQVLSTVNRQDANSDVGSTEECGKVEFTKDEVLALLNERAKAGKFDTKGKIEQMTDIIKKLKVCVRWYQQVDETHVQDKENLSSSLQSAEKRYSDKELDAKTKEEELRATITEMKENIESLQEKLSKEKLSKLDAIENHRREKDCRVVAEKLQVSLREELDKVKEEKMAAKQKVTSLEDMYKRLQEYNTSLQQYNTKLQTDLEVAREAHTRAEKEKSSILENLTTLRGHSKSLQDQLASSRVSQDEAVKQKDSLLMEVNNLQSELQQVRDDRDRHVVQSQKLAGEILMYKESVGKSSHELDILIAKSGSLEETCSLQKERIKMLEQELAFAKEKLKMVDLSMSHTMTEFEEQKQCMHELQDRLADTERQLFEGELLRKKLHNTILELKGNIRVFCRVRPLLPDDGGRQEASVIAYPTSTESLGRGIDVVQSGNKHPFTFDKVFDHGASQEEVFFEISQLVQSALDGYKVCIFAYGQTGSGKTYTMMGRPETPEQKGLIPRSLEQIFKTSQSLSTQGWKYKMQVSMLEIYNESIRDLLSTSRTIAIESVRADSSTSGRQYTITHDVNGNTHVSDLTIVDVCSIGQISSLLQQAAQSRSVGKTHMNEQSSRSHFVFTLRISGVNESTEQQVQGVLNLIDLAGSERLSRSGATGDRLKETQAINKSLSALSDVIFALAKKEDHVPFRNSKLTYLLQPCLGGDSKTLMFVNISPDPSSTGESLCSLRFAARVNACEIGIPRRQTSAKLLDSRLSYG
What is the function of this protein?
Kinesin that supports microtubule movement in an ATP-dependent manner and that functions as a minus-end directed motor as well as a plus-end tracking protein.  During mitosis, is involved in early spindle assembly.  Participates in the capture of antiparallel interpolar microtubules and helps in generating force to coalign microtubules.
What are the official names of this protein?
Kinesin-like protein KIN-14D, AtKIN14b.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, phragmoplast. Note=In interphase, is enriched specifically at growing microtubule plus-ends. In dividing cells, accumulates in spindle midzones and phragmoplast leading edges.
Protein: Y202_MYCPN
Sequence: MGSQNQGSTTTTSAGNPDSLVTDKVDQKGQVQTSGQNLSDTNYTNLSPNFTPTSDWPNALSFTNKNNAQRAQLFLHGLLGSIPVLVNKSGENNEKFQATDQKWSYTELKSDQTKLNLPAYGEVNGLLNPALVETYFGTTRTSSTANQNSTTVPGIGFKIPEQNNDSKAVLITPGLAWTPQDVGNLVVSGTSFSFQLGGWLVSFTDFVKPRAGYLGLQLTGLDASDATQRALIWAPPALSGLSWQLGQPVGPRGECVGFEGGVGGSSSVRLARIYHHRNRGYLTGAPECFGLSGECGGSECLQAKHELRPNPIH
What are the official names of this protein?
Putative adhesin P1-like protein MPN_202.
What is the protein family that this protein belongs to?
Belongs to the adhesin P1 family.
Protein: TIG_ECO27
Sequence: MQVSVETTQGLGRRVTITIAADSIETAVKSELVNVAKKVRIDGFRKGKVPMNIVAQRYGASVRQDVLGDLMSRNFIDAIIKEKINPAGAPTYVPGEYKLGEDFTYSVEFEVYPEVELQGLEAIEVEKPIVEVTDADVDGMLDTLRKQQATWKEKDGAVEAEDRVTIDFTGSVDGEEFEGGKASDFVLAMGQGRMIPGFEDGIKGHKAGEEFTIDVTFPEEYHAENLKGKAAKFAINLKKVEERELPELTAEFIKRFGVEDGSVEGLRAEVRKNMERELKSAIRNRVKSQAIEGLVKANDIDVPAALIDSEIDVLRRQAAQRFGGNEKQALELPRELFEEQAKRRVVVGLLLGEVIRTNELKADEERVKGLIEEMASAYEDPKEVIEFYSKNKELMDNMRNVALEEQAVEAVLAKAKVTEKETTFNELMNQQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
Protein: T200_SALTY
Sequence: MGDEKSLAHTRWNCKYHIVFAPKYRRQAFYGEKRRAVGSILRKLCEWKNVRILEAECCADHIHMLLEIPPKMSVSSFMGYLKGKSSLMLYEQFGDLKFKYRNREFWCRGYYVDTVGKNTAKIQDYIKHQLEEDKMGEQLSIPYPGSPFTGRK
What is the function of this protein?
Transposase responsible for transposition of the IS200 insertion sequence (IS) element.  Transposition occurs in 2 main steps, excision from the donor DNA 'top strand' into a single strand circle and its subsequent reinsertion into the DNA target.  This increases the copy number of the IS.
What are the official names of this protein?
Transposase for insertion sequence element IS200.
What is the protein family that this protein belongs to?
Belongs to the transposase 17 family.
Protein: LKA16_MANHA
Sequence: MGNKLTNISTNLKSSWLTAKSGLNRTGQSLAKAGQSLKTGAKKIILYIPKDYQYDTEKGNGLQDLVKAAQELGIEVQKEEGNDIAKAQTSLGTIQNVLGLTERGIVLSAPQLDKLLQKTKVGQAIGSAENLTKGFSNAKTVLSGIQSILGSVLAGMDLDEALQKNSNELTLAKAGLELTNSLIENIANSVKTLDAFGDQINQLGSKLQNVKGLSSLGDKLKGLSGFDKTSLGLDVVSGLLSGATAALVLADKNASTSRKVGAGFELANQVVGNITKAVSSYILAQRVAAGLSSTGPVAALIASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASVTAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKNNGGKNYFENGYDARYLANLQDNMKFLLNLNKELQAERVIAITQQQWDSNIGDLAGISRLGEKVLSGKAYVDAFEEGQHLKADKLVQLDSAKGIIDVSNTGEAKTQHILFRTPLLTPGTEKRERVQTGKYEYITKLHINRVDSWKITDGAASSTFDLTNVVQRIGIELDNAGNVTKTKETKIIAKLGEGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKETEQGSYTVNRFVESGKALHEVTSTHTALVGNREEKIEYRHSNNQHHAGYYTKDTLKAVEEIIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDIIDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRQGDGNDSITESEGNDKLSFSDSNLKDLTFEKVNHHLVITNTKQEKVTIQNWFREAEFAKTIQNYVATRDDKIEEIIGQNGERITSKQVDELIEKGNGKIAQSELTKVVDNYQLLKYSRDASNSLDKLISSASAFTSSNDSRNVLASPTSMLDPSLSSIQFARAA
What is the function of this protein?
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture.  The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity).  This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis.  It has also weak hemolytic activity.
What are the official names of this protein?
Leukotoxin, Lkt.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein: DLTC_BACLD
Sequence: MDFNQEVLSVLAEVCQDDIVKENPDIDIFEEGILDSFGTVELLLAFESHFNITVPITEFDRDAWNTPNQIIKQLNELR
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSR_PYRFU
Sequence: MEKKKVVIIGGGAAGMSAASRVKRLRPEWDVKVFEATEWVSHAPCGIPYVVEGIAPKEKLMHYPPEVFIKKRGIDLHLKAEVIEVETGYVRVRENGEEKSYEWDYLVFANGASPQIPEIEGVDLPGVFTADLPPDAVAITEYMEKNKVEDVVIIGTGYIALEMAEAFVTRGKNVTLIGRSERVLRKTFDKEITDIVEEKLRQHLNLRLHEKTLSIEGRERVEKVITDGGEYKADLVIIATGIKPNVELAKQLGVKIGETGAIWTNEKMQTSVENVYAAGDVAETKHVITGKRVWIPLAPAGNKMGYVAGSNIAGKEIEFPGVLGTSITKFMDLEIGKTGLTENEAVKEGYDVRTAFIKANTKPHYYPGGREIWLKGVVDNETNRLLGVQAVGAEILPRIDSAAAMITAGFTTKDVFFTDLAYAPPFAPVWDPLIVLARVLKF
What is the function of this protein?
Catalyzes the CoA-dependent reduction of elemental sulfur (S(0)) to produce hydrogen sulfide (PubMed:17449625, PubMed:24723088).  Can use both NADPH and NADH, but shows a preference for NADPH (PubMed:24723088).  May enable S(0) to be used, via sulfide, for iron-sulfur cluster synthesis by SipA (Probable).  Also shows coenzyme A disulfide reductase (CoADR) activity with both NADH and NADPH (PubMed:15720393, PubMed:17449625).  However, CoADR specific activity is about 20-fold lower than the sulfur reduction assay and CoADR activity appears to be an artifactual side reaction and is not thought to have any physiological relevance (PubMed:17449625).  Also shows NAD(P)H oxidase activity with both NADH and NADPH (PubMed:24723088).
What are the official names of this protein?
NAD(P)H sulfur oxidoreductase (CoA-dependent), NSR, Coenzyme A disulfide reductase, CoA-disulfide reductase, CoADR, NAD(P)H oxidase, NOX.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3NX4_DISTY
Sequence: MKTLLLSLVMVGFMYLVSGQNRTCRSCTGALCLKIEQCKEGQNLCFERKITDDFFGMKTVRGCADTCANPGENEKVTYCSTDNCNS
What are the official names of this protein?
Toxin 3FTx-Dis4.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Ancestral subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GB_HSV2S
Sequence: MRPRGTPPSFLPLPVLLALAVIAAAGRAAPAAAAAPTADPAATPALPEDEEVPDEDGEGVATPAPAANASVEAGRATLREDLREIKARDGDATFYVCPPPTGATVVQFEQPRPCPRAPDGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVMDKINAKGVCRSTAKYVRNNMESTAFHRDDHESDMALKPAKAATRTSRGWHTTDLKYNPARVEAFHRYGTTVNCIVEEVEARSVYPYDEFVLATGDFVYMSPFYGYRDGSHGEHTAYAADRFRQVDGYYERDLSTGRRAAAPVTRNLLTTPKFTVGWDWAPKRPSVCTLTKWREVDEMLRAEYGPSFRFSSAALSTTFTANRTEYALSRVDLADCVGREAREAVDRIFLRRYNGTHVKVGQVQYYLATGGFLIAYQPLLSNALVELYVRELVREQTRRPAGGDPGEAATPGPSVDPPSVERIKTTSSVEFARLQFTYDHIQRHVNDMLGRIATAWCELQNRELTLWNEARRLNPGAIASATVGRRVSARMLGDVMAVSTCVPVAPDNVIMQNSIGVAARPGTCYSRPLVSFRYEADGPLVEGQLGEDNEIRLERDALEPCTVGHRRYFTFGAGYVYFEEYAYSHQLGRADVTTVSTFINLNLTMLEDHEFVPLEVYTRQEIKDSGLLDYTEVQRRNQLHALRFADIDTVIKADAHAALFAGLYSFFEGLGDVGRAVGKVVMGIVGGVVSAVSGVSSFLSNPFGALAVGLLVLAGLAAAFFAFRYVMRLQRNPMKALYPLTTKELKSDGAPLAGGGEDGAEDFDEAKLAQAREMIRYMALVSAMERTEHKARKKGTSALLSAKVTDAVMRKRARPRYSPLRDTDEEEL
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: CH10_SALSV
Sequence: MSIRPLHDRVIVKRKEVESKSAGGIVLTGSAAGKSTRGEIIAVGKGRILDNGTVQPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_GEMAT
Sequence: MPTINQLVRRARKDVVEKSKAPALKSNPFKRGVCTRVYTTTPKKPNSALRKVARIRLTNQLEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGTLDASGVNGRNQSRSKYGTKRPKPGQAAAGGKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PRMC_MYCTU
Sequence: MTLRQAIDLAAALLAEAGVDSARCDAEQLAAHLAGTDRGRLPLFEPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALAQHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVTTPRLLPELDGQVDLMVSNPPYIPDAAVLEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLFVDVQARKDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR
What is the function of this protein?
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
What are the official names of this protein?
Release factor glutamine methyltransferase, RF MTase, M.MtuHHemKP, N5-glutamine methyltransferase PrmC, Protein-(glutamine-N5) MTase PrmC, Protein-glutamine N-methyltransferase PrmC.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein: Y387_ATV
Sequence: MVAQEMAQEKNLQPWEYVYDLLMPAKIPPRKRTKYIYLALAVPPTMEFNKKISKGDTEDLELPVYPVAFNTRPGNNKADRIATRKDLLTRLGTYPTVGLYANDYDFTMLIKNLDFKSEFVPGYFPLAVLELHFERDITANPEDYGLKPIDGREWVFDPDGSYKVTSGSLFNIAKAEIVDPNSVTINLDKNSKEFNALNGYGVVQFYIDLNNAPWEAYAKAAEECESVGGIYRHDTNEGPSYCTLPLNKEANIKASEFILQLYDMIKSKIASEDFLKREMTFLAPGPKQIEDFLKNEMMYQPPGPKRIPVKPVIGKTFQEMVKVAEQEMAKVAEKRDLILGGEEKEPKQKSQEKLFNPFAIDYEMLTEEQQQQNETEEEEKNNTVKLS
What are the official names of this protein?
Structural protein ORF387.
What are the subcellular locations of this protein?
Virion.
Protein: PROB_PSEP1
Sequence: MRSKVTGAKRWVVKIGSALLTADGKGLDRGAMAVWVEQMVALREAGVELVLVSSGAVAAGMSQLGWTKRPSAMNELQAAASLGQMRLVQAWESSFGEHGKHTAQILLTHDDLSDRKRYLNARSTLRTLVDLGVVPVINENDTVVTDEIRFGDNDTLAALVANLVEADLLVILTDRDGMFDADPRNNPEAQLIYEARADDPSLDAVAGGTGGALGRGGMQTKLRAARLAARSGAHTIIIGGRIERVLDRLKAGERLGTLLSPERGMLAARKQWLAGHLQTRGTLVLDAGAVQALRQANKSLLPVGVKTVQGSFRRGEMVVCVGPDGVEVARGLANYSALEAQKIIGQSSEAIESILGYSAEPELVHRDNLVLV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURE_STRA3
Sequence: MITIDKILEILKNDHNFREILFHEHYYYNWTQNVTFNALSYDSRQISSDTLFFAKGATFKKEYLDSAITAGLSFYVSEIDYGADIPVILVNDIKKAMSLISMSFYNNPQNKLKLLAFTGTKGKTTAAYFAYHMLKVNHRPAMLSTMNTTLDGKSFFKSHLTTPESLDLFRMMATAVENQMTHLVMEVSSQAYLTKRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFFHKRLLMENSNAVVVNSQMDHFNIVKEQVEYIPHDFYGDYSENVITESQAFSFHVKGKLENTYDIKLIGKFNQENAIAAGLACLRLGVSIEDIKNGIAQTTVPGRMEVLTQTNGAKIFVDYAHNGDSLKKLLAVVEEHQKGDIILVLGAPGNKGQSRRKDFGDVINQHPNLQVILTADDPNFEDPLVISQEIASHINRPVTIIIDREEAIANASTLTNCKLDAIIIAGKGADAYQIIKGNRDNYSGDLEVAKKYLKR
What is the function of this protein?
Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase, L-lysine-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:L-Lys ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.