PharMolix/UniProtQA huggingface dataset:
Protein: SCNAA_RAT
Sequence: MELPFASVGTTNFRRFTPESLAEIEKQIAAHRAAKKARTKHRGQEDKGEKPRPQLDLKACNQLPKFYGELPAELVGEPLEDLDPFYSTHRTFMVLNKSRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITITILVNCVCMTRTDLPEKVEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKCIRNGTDPHKADNLSSEMAEYIFIKPGTTDPLLCGNGSDAGHCPGGYVCLKTPDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEEQSQATIAEIEAKEKKFQEALEVLQKEQEVLAALGIDTTSLQSHSGSPLASKNANERRPRVKSRVSEGSTDDNRSPQSDPYNQRRMSFLGLSSGRRRASHGSVFHFRAPSQDISFPDGITDDGVFHGDQESRRGSILLGRGAGQTGPLPRSPLPQSPNPGRRHGEEGQLGVPTGELTAGAPEGPALDTTGQKSFLSAGYLNEPFRAQRAMSVVSIMTSVIEELEESKLKCPPCLISFAQKYLIWECCPKWRKFKMALFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSASKKGSLSVLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSEDYGCRKDGVSVWNGEKLRWHMCDFFHSFLVVFRILCGEWIENMWVCMEVSQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQLALARIQVLGHRASRAIASYISSHCRFRWPKVETQLGMKPPLTSSEAKNHIATDAVSAAVGNLTKPALSSPKENHGDFITDPNVWVSVPIAEGESDLDELEEDMEQASQSSWQEEDPKGQQEQLPQVQKCENHQAARSPASMMSSEDLAPYLGESWKRKDSPQVPAEGVDDTSSSEGSTVDCPDPEEILRKIPELADDLDEPDDCFTEGCTRRCPCCNVNTSKSPWATGWQVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSKCVDTRNNPFSNVNSTMVNNKSECHNQNSTGHFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLICLNMITMMVETDEQGEEKTKVLGRINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVILSIGSLLFSAILKSLENYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFANVVDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKTNMEEKFMATNLSKASYEPIATTLRWKQEDLSATVIQKAYRSYMLHRSLTLSNTLHVPRAEEDGVSLPGEGYVTFMANSGLPDKSETASATSFPPSYDSVTRGLSDRANINPSSSMQNEDEVAAKEGNSPGPQ
What is the function of this protein?
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient.  Plays a role in neuropathic pain mechanisms.
What are the official names of this protein?
Sodium channel protein type 10 subunit alpha, Peripheral nerve sodium channel 3, PN3, Sensory neuron sodium channel, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=It can be translocated to the cell membrane through association with S100A10.
Protein: MVP_POLVP
Sequence: MEIQSLDGVLGEELAIQNEVKKILLSHKTTKAILPLAPISQFSKWKIPKQGFYAPIDVKFVLTPHISERAQVRGVVKLVDSRDLSPSRELYRSKEFNIGHGLVIEGSQLPFCLPVGDYPLQFEVTVLQSQFRETANLYSTSVEWRMMSSTTPLSRVRSVMGAAQQPAMKLQPNFKMSLESSKGGGMKPHQKKSSKPNGHSRRGNLSGEVGGSSSSLPSGAQTGEWIDNDYGDGSSEYSGVST
What is the function of this protein?
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding.  The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier (By similarity).
What are the official names of this protein?
Movement protein, p27.
What is the protein family that this protein belongs to?
Belongs to the tombusvirus/aureusvirus movement protein p22 family.
Protein: RF3_SYNY3
Sequence: MQTSPSSTAPCADKALDDLLKEVDRRRNFAIISHPDAGKTTLTEKLLLYGGAIQEAGAVKARRSQRSATSDWMAMEQQRGISITSTVLQFDYRGKILNLLDTPGHQDFSEDTYRTLAAADNAVMLIDAAKGLETQTRKLFEVCRLRHLPIFTFINKLDRPSLTPLELMDEIEQELGMNTYAVNYPIGTGDRFRGVYNRLTKTIHLFERTGTHGSKKAADQTMALDDPALESLLGSDVYAEFQDELELIEEAGAEFDLAAVHGGEMTPVFFGSAMNNFGVELFLQAFLQYAAKPEAHDSNRGTIEPTYEEFSGFVFKLQANMDPKHRDRIAFLRVCSGKFEKDMVVKHPRTGKTVRLSRPQKLFAQERESVDIAYAGDVIGLNNPGAFTIGDTVHTGEKIIYPPIPSFSPELFAYLRSTDPSQYKNFKKGVSELQEEGAVQILQSLDESKRDPILAAVGQLQFEVVQYRLQEEYGVETRLEPLGFSLARWVVEGWDALEKAGRLFNTVVVKDRWDAPVLLFKNQWNLEQVAGDCLDLKLSAIAIPPSL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity).
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTOX_SHIDS
Sequence: MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGDTRLIRHAYGEGEKYVPLVLRAQTLWDDLSRHNEDDPIFVRSGVINLGPADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWIQLAKEAGCAQLFNCPVTAIRHEDDGVTIETADGEYQAKKAIVCAGTWVKDLLPELPVQPVRKVFAWYQADGRYSVKNKFPAFTGELPNGDQYYGFPAENDALKIGKHNGGLVIHSADERVPFAEVASDGSEAFPFLRNVLPGIGCCLYGAACTYDNSPDEDFIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSRFQ
What is the function of this protein?
Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.
What are the official names of this protein?
N-methyl-L-tryptophan oxidase, MTOX.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family. MTOX subfamily.
Protein: NPR3_NEOFI
Sequence: MSSIARPPDPCLVAIILIVRSRAGPRFVFHYPPNPLSENGLRPVRKERRTSRSKNGQGYKSNESSSSEESGSSSDDDEDEHQRQLQSQNQSQSHLSGSVVSGRRSSNFGLDDHVAMSVSPGGDSQRAGSMGSGRTSFRKRGGNSDVEEDSGAASDRQEDGSGGAGGPYRPPWESLLGLPADVWEKLLSPSPAWHKRRFEVGINDLAFIGWPVFVREDGTWRKQRRKKKKKWRAEWEGGELGHNENAEDAPDDEDGDAGGNASGGGGLMAASTETLSPKQMALSEAKRGSGSSSKAARSSVDCLDGDDKDSMTMFNVVFVLDPPLLEYSMRTREIYDNIIKKFAKALKWEQARTDYVWREAQHISHLKEKAKERRTSLNTLYTELINQSSLARAIYTVYTSISASKIASVQLSPDVSISLQIPPLTSTPYLPGPTDKAYPGLWLTTADSVTPVEDPTADENTAPHQVLAKHFALLLLDNEAAILKDVEASGGALAPALAHYLRCSKPTKSFAQISASSGIPLSTIQMLASHLVYWRRARAIPPIHQRDTYIVSPNCDLSKLEIATAAYQVAFPTLPSLPKMLSALSGTPRPYGSFIPSKDHKETYFAILAWLLRGGWVTQLRSFARVKVTPEIKMAVEVALRREEVDKYLRKGRSLEAQKSADGENGNEADENDDASSSSSSSLASQGSGDETPMPGRYQQESNLRLSHSMLDRNTSLRTSSLILFPHRASPLESRWLEQIVSRFPEHPRTAGRHRRGEGSNAAGGEIDPEYAALSTPMKDLWPTYIKYFNGLDALEKIPVREGLKRKLVWQVLTRLGLVTSQQSSIELDPREQVLVSVRHW
What is the function of this protein?
Mediates inactivation of the TORC1 complex in response to amino acid starvation.  Required for meiotic nuclear division (By similarity).
What are the official names of this protein?
Nitrogen permease regulator 3, Required for meiotic nuclear division protein 11.
What is the protein family that this protein belongs to?
Belongs to the NPR3 family.
Protein: HSDHB_RUMGN
Sequence: MTLREKYGEWGIILGATEGVGKAFCERLAKEGMNVVMVGRREEKLKELGEELKNTYEIDYKVVKADFSLPDATDKIFAATENLDMGFMAYVACLHSFGKIQDTPWEKHEAMINVNVVTFMKCFYHYMKIFAAQDRGAVINVSSMTGISSSPWNGQYGAGKAFILKMTEAVACETEKTNVDVEVITLGTTLTPSLLSNLPGGPQGEAVMKTAQTPEEVVDEAFEKLGKELSVISGERNKASVHDWKANHTEDDYIRYMGSFYQE
What is the function of this protein?
7beta-hydroxysteroid dehydrogenase that catalyzes the reduction of the 7-oxo group of 7-oxo-lithocholate (7-oxo-LCA), to yield ursodeoxycholate (UDCA).  As R. gnavus is a common core bacterium of the human gut microbiota, this enzyme contributes to the formation of UDCA in the human colon.  UDCA is regarded as a chemopreventive beneficial secondary bile acid due to its low hydrophobicity; it protects hepatocytes and bile duct epithelial cells against necrosis and apoptosis induced by more hydrophobic secondary bile acids like deoxycholate (DCA).  This enzyme is also able to catalyze the reverse reaction in vitro, i. e.  the oxidation of the 7beta-hydroxy group of UDCA to 7-oxo-LCA, but much less efficiently than the reduction reaction, and this oxidation reaction is not observed in vivo.  It is specific for NADPH/NADP(+) as the electron acceptor/donor since the activity observed with NADH/NAD(+) is less than 0. 5% of that assayed using NADPH/NADP(+) in both directions.
What are the official names of this protein?
7beta-hydroxysteroid dehydrogenase, 7beta-HSDH, NADP-dependent 7beta-hydroxysteroid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RNH2_ALISL
Sequence: MTKKIDSKELPPFEYPQGYQLFAGVDEVGRGPLVGAVVTAAVILDPNNPIEGLTDSKKLTEKKRDLLFPEIQEKALAWSLGRCEAHEIDELNILQATMVAMQRAIAGLKVTPDFALIDGNKVPELPMAGLAVVKGDLRVQEISAASILAKVTRDREMEVLDKEFPQYGFAKHKGYPTKAHFAAIEEHGVISEHRRSFKPVKRVLGIE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Z385B_DANRE
Sequence: MQLQQEKKKLLYSLCDVCNIQLHSAAQAQVHYNGKSHLKRVKQLNNGEVPKASASLAPTSLQSLSSSSSQGSSCHSNTLPTLVRTPSLMMQSGLDMKPFMTFPVESSSPVGLFPNFNTMDPVQKAVINHTFGVSIPPKKKQVISCNICQLRFNSDSQAEAHYKGSKHAKKLKAQESPKNKQKSAVAQDSGTKTITSTSTNTTTTTTTTSSCTAVTASCSDQTEKSTEPLAAHKVPASPQAFVPAPVAPAVALVPSPCKTAPVHASPPTEPTGLAVALKNTSKPAALPTAPSEPSVESEEEKAKKLLYCSLCKVAVNSLSQLEAHNTGSKHKTMLEARNGAGPIKAYPRPGSKLKVQATQLNKGSGLQNKTFHCEICDVHVNSEIQLKQHISSRRHKDRVAGKPTKPKYSPYNKQQRSSSSLAAKLALQNDLVKPISPAFLPSPFSTTTVPSISLHPRPNTSIFQTASLPHSFLRAAPGPIRPTTGSILFAPY
What is the function of this protein?
May play a role in p53/TP53-mediated apoptosis.
What are the official names of this protein?
Zinc finger protein 385B, Zinc finger protein 533.
What are the subcellular locations of this protein?
Nucleus.
Protein: ORFZB_MAGO7
Sequence: MHHFFKGQFFDFETCRILGTAVYGGADVAEVLEAVGQIRDGDPVSWGRAWAIQAERALVLAEEACKSGDRTAARDAYLRGSNYTRASGYMLTGEGPNRPDPRSREIVERVQAIFRKAAALFDHPVQFLKIPFEGGLKLPCTLYLPPPDRRLPGKIPILISGGGADALQEELYYMHPSAGPDLGYAVLTFEGPGQGVMLRKHDAKMRPDWEAVAGAVIDFLEELARSQPDLDLDTSRIAFSGCSLGGYFALRAAADPRVKACVSLDPLYSFWDFAMEHVSPTFINAWEAGWLKDGAVDAVVRMMMAMSFQMRWELSIAGTFFGQTSPARIMKEMKKFSLAGGQLRRVQCPVLVSGASHSLYLEGNHHTMRIYNELVNHTKGDKQLWLTATPGQGSLQAKMGALRLANQKTFKFLDEHFGIERPQL
What is the function of this protein?
Hydrolyase; part of the gene cluster that mediates the biosynthesis of a tyrosine-derived cytochalasan acting as a fungal signal recognized by resistant rice plants and leads to avirulence in Pi33 resistant rice cultivars (PubMed:18433432).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS ACE1, assisted by the enoyl reductase RAP1, that are responsible for fusion of the tyrosine precursor and the polyketide backbone (PubMed:29142718).  The polyketide synthase module (PKS) of ACE1 is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the tyrosine precursor (PubMed:29142718).  Because ACE1 lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase RAP1 (PubMed:29142718).  Reduction by the hydrolyase ORFZ, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ORF3 then yield the required isoindolone-fused macrocycle (Probable).  A number of oxidative steps catalyzed by the tailoring enzymes identified within the cluster, including cytochrome P450 monooxygenases CYP1 to CYP4, the FAD-linked oxidoreductase OXR2 and the short-chain dehydrogenase/reductase OXR1, are further required to afford the final cytochalasans that confer avirulence and which have still to be identified (Probable).  The monooxygenase CYP1 has been shown to be a site-selective C-18 hydroxylase whereas the function of CYP3 is the site-selective epoxidation of the C-6/C-7 olefin that is present in some intermediate compounds (PubMed:31644300).  Finally, SYN2 and RAP2 are not required for avirulence in Pi33 resistant rice cultivars (PubMed:18433432).
What are the official names of this protein?
Hydrolase ORFZ, ACE1 cytochalasan biosynthesis cluster protein ORFZ.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.
Protein: HEM1_SHEPA
Sequence: MSLVAIGINHKTATVDLREKVAFGPDKIHDAMKSLAASTQSGEAVIISTCNRTELYCNNCEAADVVAWLEDYHQLSHEDVEPCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQSFVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVSVAFAAVSMAKHIFSSISTTQVLLVGAGETIELVARHLKDNGVTTMVVANRTISRAEAMCEEFGATAITLEQIPDFLPKADIVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQSIIEQNMASRREAAEQAELIAEDQAYQFMEWIRSLESVDSIREYRTKSMAIKDELVERAVNKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGDLNSLGQLRALLGLDKD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: FER_THELI
Sequence: MKVSVDKDACIGCGVCASICPDVFEMDDDGKAKALVAETDLECAKEAAESCPTGAITVE
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
Protein: QUEF_AZOVD
Sequence: MHPAAEDSPLGKSSEYLDTYTPSLLFPIPRAPKWAELGLAAENLPYRGVDVWNCYELSWLLPSGKPVVAVGEFVIPADSPNIVESKSFKLYLNSLNQTVFADREALRQTLARDLSAATGAPVAVRLRSLGEVQEQGVAALPGQCIDELDVTIGRYGQPSAELLRCDPARRVEQVLHSHLLKSNCPVTGQPDWGSLVVDYHGPALDPASLLAYVVSFRQHADFHEQCVERIFLDLLRLLEPGRLTVYARYVRRGGLDINPWRSTGAVVADNRRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRK14_ARATH
Sequence: MDCRLHLVLFFSCVCLICLSGQQETGFVYNGFHQEDLFIDGIAMILPGGLLQLTNASQLKIGHAFFKQPFGFDPSSSLSFYTHFVCALVPPKFGAEVGHGMAFVVSPSMNFSHAFPTQYLGVFNSSTNVTSSSHLLAIELDTVETVDFHDLEKAHVGIDVNNPISIESALPSYFSDALGKNISINLVSGEPVQVWIDYDGSLLNVTLAPIEIQKPNRPLISRDINLSEIFQDKMYIGFSGSNGRLTSNQYILGWSFSKSKEFMQSLDLSKLPQAPIPRNEQAPVPREEKKKLHPLLIGLVILLVIPVLMVLGGVYWYRRKKYAEVKESWEKEYGPHRYSYKSLYKATNGFVKDALVGKGGFGKVYKGTLPGGRHIAVKRLSHDAEQGMKQFVAEVVTMGNIQHRNLVPLLGYCRRKGELLLVSEYMSNGSLDQYLFYNQNPSPSWLQRISILKDIASALNYLHSGANPAVLHRDIKASNVMLDSEYNGRLGDFGMAKFQDPQGNLSATAAVGTIGYMAPELIRTGTSKETDVYAFGIFLLEVTCGRRPFEPELPVQKKYLVKWVCECWKQASLLETRDPKLGREFLSEEVEMVLKLGLLCTNDVPESRPDMGQVMQYLSQKQPLPDFSADSPGIGGFMPVSVEPSSTIGIPDSSMHVTHSILEGYGR
What are the official names of this protein?
Putative L-type lectin-domain containing receptor kinase I.4, LecRK-I.4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the leguminous lectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GPDA_STRPN
Sequence: MEKQTVAVLGPGSWGTALSQVLNDNGHEVRIWGNLPEQINEINTHHTNKHYFKDVVLDENIIAYTDLAETLKDVDAILFVVPTKVTRLVAQQVAQTLDHKVIIMHASKGLEPDSHKRLSTILEEEIPEHLRSDIVVVSGPSHAEETIVRDLTLITAASKDLQTAQYVQKLFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAIIARGLAEITRLGVALGASPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGESLADIEANMGMVIEGISTTRAAYELAQELGVYMPITQAIYQVIYHGTNIKDAIYDIMNNEFKAENEWS
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SO_DROME
Sequence: MLQHPATDFYDLAAANAAAVLTARHTPPYSPTGLSGSVALHNNNNNNSSTSNNNNSTLDIMAHNGGGAGGGLHLNSSSNGGGGGGVVSGGGSGGRENLPSFGFTQEQVACVCEVLQQAGNIERLGRFLWSLPQCDKLQLNESVLKAKAVVAFHRGQYKELYRLLEHHHFSAQNHAKLQALWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLRDWYSHNPYPSPREKRDLAEATGLTTTQVSNWFKNRRQRDRAAEHKDGSTDKQHLDSSSDSEMEGSMLPSQSAQHQQQQQQQQHSPGNSSGNNNGLHQQQLQHVAAEQGLQHHPHQPHPASNIANVAATKSSGGGGGGGVSAAAAAQMQMPPLTAAVAYSHLHSVMGAMPMTAMYDMGEYQHL
What is the function of this protein?
Required for visual system development.  May transcriptionally regulate genes necessary for optic lobe invagination and Bolwig's nerve formation.
What are the official names of this protein?
Protein sine oculis.
What is the protein family that this protein belongs to?
Belongs to the SIX/Sine oculis homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ENV_HTL32
Sequence: MGKFCLYFCLIYILFSASSGNPSRCTLFIGASSYHSDPCGSDHPRCTWRLDLFSLTRDQSLSPPCPDLVTYSQYHRPYSLYVFPHWITKPNRRGLGYYSASYSDPCAIQCPYLGCQSWTCPYTGPVSSPHWKYSSDLNFTQEVSSISLHLHFSKCGSSFSFLLDAPGYDPVWFLSSQATQAPPTPAPLIQDSDLQHILEPSIPWSSKILNLILLTLKSSNYSCMVCVDRSSLSSWHVLYDPLKAPNPPDPKAQSILRPSLAIPASNVTPPFPWTHCYRPLLQAISSEHCNNSVVLPPFSLSPLPNVSRPRKRRAVPIAIWLVSALAAGTGIAGGVTGSLSLASSKSLLREVDQDIDHLTQAIVKNHDNILRVAQYAAQNRRGLDLLFWEQGGLCKAIQEQCCFLNISNTHVSVLQERPPLEKRVITGWGLNWDLGLSQWAREALQTGITLLALFLLLIVVGPCVIRQLQALPSRLQHRSQPYSLLNYETNL
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp63, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: DYL1_DEBHA
Sequence: MSEKEQEPILKASDLPEEMQTRIFELSNEAVSNYKIEKDIATYLKKELDQLYGATWHVIVGKSFGSYVTHEQGFFTYFYIGQLAFLIFKSG
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).  Also a component of the nuclear pore complex (By similarity).
What are the official names of this protein?
Dynein light chain 1, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus, nuclear pore complex.
Protein: IP5P9_ARATH
Sequence: MWPRLVANKILRKSLGSNNFVADFPPNTDQKLIEASGLADERSKSILHNQHKTTLLNYKVFVSTWNVGGIVPDDGLDMEDLLETHKTPCDIYVLGFQEVVPLRASNVLGSDNNKVSTKWNSLIRDALNKRARPHRDEDLSESKGINGISQDFRCIISKQMVGILITVWVRGDLWPYIRYPSVSCVGCGIMGCLGNKGSVSVRFQLHETTFCFVCSHLASGGRDRDERQRNSDVNEILARSSFPRGSSLDLPKKILDHDRVIFLGDLNYRISLPEEKTRLLVESKKWNILLENDQLRMEIMNGQIFRGWQEGIVKFAPTYKYVPNSDLYYGCITYKKDEKKRAPAWCDRIIWYGNGLKQHEYTRGETKISDHRPVKAIFTTEITVTRRGKKIRNFFFSDRFEERIGDIDSKDYSWIST
What is the function of this protein?
Has phosphatase activity toward PtdIns(4,5)P2 and at a lower extent toward PtdIns(3,4,5)P3 but not toward Ins(1,4,5)P3.  Functions in salt stress response by regulating reactive oxygen species (ROS) production, endocytosis, Ca(2+) influx and stress-responsive genes expression.
What are the official names of this protein?
Type IV inositol polyphosphate 5-phosphatase 9, At5PTase9.
What is the protein family that this protein belongs to?
Belongs to the inositol polyphosphate 5-phosphatase family.
Protein: ZAPA_KLEP3
Sequence: MSAQPVDLQIFGRSLRVNCPPEQRDALNQAAEDLNQRLQDLKERTRVTNTEQLVFIAALNISYELTQEKAKTRDYASSMEQRIRMLQQTIEQALLEQGRISERPGSKFE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell.
Protein: RS5_MARSD
Sequence: MEQNDLGLIEKIVYLNRVAKVVKGGRRFSFSALVVVGDGKGQVGFGLGKANEVPEAIRKASEKARKEMISVPLLDGTLPYEVLGRYGAGRVMLKPASKGTGIIAGGPVRAVLEVVGVHDILTKAIGTNNPHNVLRATIAGLASLRSADEVGQLRGKKVVTPRK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: TDCC_ECOBW
Sequence: MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYEKDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.