PharMolix/UniProtQA huggingface dataset:
Protein: RSMH_SHESM
Sequence: MSQEFAHLSVLLEETVGGLNIKDDGIYIDGTFGRGGHSRQVLQRLGENGRLIAIDRDPQAIEAAKQFADDPRFQIVHGGFGQLADYVEELGLVGKIDGVLLDLGVSSPQLDDAERGFSFLRDGPLDMRMDNSQGETAAQWLARAEIEDMAWVFKTYGEEKNARHIARCIAADRDKTPFLRTKDLADLIARITKNKERNKHPATRVFQAIRIYINSELDQIDQALEGALTVLAPQGRLSIISFHSLEDRIVKRFIRRHSQGESVPHGLPITEDQINKSRKLRAIGKAIMPSDEEIERNARARSSVLRIAERLDY
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP5_STRAW
Sequence: MNRPSARYALPEFTERLSTGLRTLDPYSKLLDERIVFLGTPIDDTSANDVMAQFMHLEHLAPDRDISLYINSPGGSFSAMTAVYDTMQFVSCDVETICLGQAASAAAVLLAGGTPGKRLALPGARVLIHQPSLPAPVQGQASDLVIQAAELARTREQLEELLVRHTGQSPERVAADIERDKILDAPAAVAYGLVDRVVPSRKSSAAAPGAR
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 5, Endopeptidase Clp 5.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S2541_BOVIN
Sequence: MGAQPEQTQKPSSRVQTLFKRVKAFFTKTGPPPPPPAPSRNLGCTHVYGYVFGHLGEREPEHSPSQQVLDTGEQLMVPVDVLEVDNEGALWKFLLSGAMAGAVSRTGTAPLDRAKVYMQVYSSKKNFMNLLGGLRSLIQEGGIRSLWRGNGINVLKIAPEYAIKFSVFEQCKNYFCGVHESPPFQERLLAGSLAVATSQTLINPMEVLKTRLTLRRTGQYKGLLDCARQILEQEGTRALYRGYLPNMLGIIPYACTDLAVYEMLNCLWLKSGRDMKDPSGLVSLSSVTLSTTCGQMASYPLTLVRTRMQAQGQLGPFSNLAYHDPLPLLSELSHDPPKHTQTDSQTLHI
What is the function of this protein?
Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane.
What are the official names of this protein?
Mitochondrial carrier protein SCaMC-3L, Mitochondrial ATP-Mg/Pi carrier protein SLC25A41, Small calcium-binding mitochondrial carrier protein 3-like, SCaMC-3-like, SCaMC-3L, Solute carrier family 25 member 41.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: OGG1_THEP1
Sequence: MEELLKELERIREEAKPLVEQRFEEFKRLGEEGTEEDLFCELSFCVLTANWSAEGGIRAQKEIGKGFVHLPLEELAEKLREVGHRYPQKRAEFIVENRKLLGKLKNLVKGDPFQSREFLVRNAKGIGWKEASHFLRNTGVEDLAILDKHVLRLMKRHGLIQEIPKGWSKKRYLYVEEILRKVAEAFGESPGKFDLYLWYLVKGKVDK
What is the function of this protein?
Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA.  Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).
What are the official names of this protein?
8-oxoguanine DNA glycosylase/AP lyase.
What is the protein family that this protein belongs to?
Belongs to the type-2 OGG1 family.
Protein: RS5_XANC8
Sequence: MAEERAPRGRDRDRNREEKVDDGMIEKLVAVNRVSKTVKGGRQFTFTALTVVGDGLGKVGFGYGKAREVPVAIQKSMEQARKNLATVDLNNGTLWHAVKSGHGAARVYMQPASEGTGVIAGGAMRAVLEAVGVKNVLAKAVGSRNPINLVRATLKGLSEVQSPARVAAKRGKKVEELNHG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: LAX14_ORYSJ
Sequence: MASEKVETIVAGNYVEMEREGAATAGEGVGGAAAASGRRRGKLAVSSLFWHGGSVYDAWFSCASNQVAQVLLTLPYSFSQLGMASGVAFQVFYGLMGSWTAYLISVLYVEYRTRRERDKVDFRNHVIQWFEVLDGLLGRHWRNAGLLFNCTFLLFGSVIQLIACASNIYYINDRLDKRTWTYIFGACCATTVFVPSFHNYRVWSFLGLLMTSYTAWYLTVAAVVHGKVDGAAPRAGPSKTMVLYFTGATNILYTFGGHAVTVEIMHAMWRPRRFKMIYLAATAYVLTLTLPSAAAMYWAFGDALLDHSNAFALLPRTPWRDAAVVLMLIHQFITFGFACTPLYFVWEKAIGVHGGAGVLRRAAARLPVVLPIWFLAVIFPFFGPINSTVGSFLVSFTVYIIPAMAHMATFAPAAARENAVEPPPRALGGWPGTFAANCFVVAWVLVVGFGFGGWASTVNFVRQVDTFGLFTKCYQCPPRH
What is the function of this protein?
Carrier protein involved in proton-driven auxin influx.  May mediate the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips (By similarity).
What are the official names of this protein?
Putative auxin transporter-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.1) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NK2R_CANLF
Sequence: MGAHAIVTDANISSSLENNTTGITAFSMPGWQLALWATAYLVLVLVAVTGNATVIWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCHFQNLFPITAMFVSIYSMTAIAADRYVAIVHPFQPRLSAPGTRAVIAGIWLLALALAFPQCFYSTITMDQGATKCVVVWPEDNGSKMLLLYHLVVIALIYVLPLLVMLLAYSVIGLTLWRREVPRHQVHGASLRHLRAKKKFVKTMVLVVVTFAICWLPYHFYFILGSFQEDIYYHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDKIELTHTPSLSARINRCHTKETFFMAGETALSPATNGQARGPQDGLPDEP
What is the function of this protein?
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A).  It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
What are the official names of this protein?
Substance-K receptor, SKR, NK-2 receptor, NK-2R, Neurokinin A receptor, Tachykinin receptor 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COAX_LISMH
Sequence: MILVIDVGNTNCTVGVYEKQKLLKHWRMTTDRHRTSDELGMTVLNFFSYANLTPSDIQGIIISSVVPPIMHAMETMCVRYFNIRPLIVGPGIKTGLNLKVDNPREIGSDRIVNAVAASEEYGTPVIVVDFGTATTFCYIDESGVYQGGAIAPGIMISTEALYNRAAKLPRVDIAESNQIIGKSTVASMQAGIFYGFVGQCEGIIAEIKKQSNASPVVVATGGLARMITEKSSAVDILDPFLTLKGLELLYRRNKPTTEK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_CALBD
Sequence: MRSDTVKKGFEKAPQRSLFKAMGYTDEEIRRPLIAVVNSWNEVVPGHIHLDRIAEAVKAGIRLAGATPMEFNVIGVCDGIAMGHIGMKYSLITRELIADSIEAMVMAHQFDGMVLIPNCDKIVPGMLIAAARVNIPAILISGGPMLAGKIGDKVCDLNSVFEGVGAYSAGKISEEDLYALEENACPGCGSCSGMFTANTMNCLSEVLGLALPGNGTIPAVMAARIRLAKMAGMKIVELVEKDIKPSDILTVEAFENALAVDMALGGSTNTILHLPAIANEVGIKLNLDIINAISDRTPNLCKLSPAGQHHIEDLYFAGGVQAVMNELSKKGLLHLNLMTVTGKTVGENIKDANVKNYNVIRPIDNPYSETGGLVIVRGNLAPDGAVVKKSAVPPKLMKHRGPARVFESGEEVFEAILKGKIQKGDVIVIRYEGPKGGPGMREMLSPTSALAGVGLIEDVALITDGRFSGATRGACFGHVSPEAAERGPIAAVQDGDMISIDIENKTLTLEVPEEEIKRRLEILPPFEPKVKKGYLYRYSKLVRSASTGAILE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RLA1_RAT
Sequence: MASVSELACIYSALILHDDEVTVTEDKINALIKAAGVNVEPFWPGLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSAAAAPAEEKKVEAKKEESEESEDDMGFGLFD
What is the function of this protein?
Plays an important role in the elongation step of protein synthesis.
What are the official names of this protein?
60S acidic ribosomal protein P1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Protein: Y248_LISIN
Sequence: MRLDKYLKVSRLIKRRTVAKEVAEKGRIAVNGVTAKPGTNVKSGDELVIRFGPKIVTAKIERLEENAKKEQATEMYTILKEERTDESR
What are the official names of this protein?
Uncharacterized protein Lin0248.
Protein: Y2192_ARATH
Sequence: MSFDVRSEKIDLIKGPELPDYNMFMSQKFTSYEGKLAILLTGNGDCSFYMWILEDAAKHEWSKKAYVVPDFFPLDPFVLLMQRANENDIVRTFHYDDRVGTSDAIVESTPASPPRHIMFSVIIRKDSPLRNLRGAKSIFKVSFTIILKTFIVKLIMMKDFQLDGDMIISKTLSRTDVDHHGRLFLPKNQVLSVLKKMRNVTKESLRKGIELEVVDIIENDSYSVILKSRNTTNDFVLASGWSIMKHSLDLQEGDDIKLFWDYLNYKFIILNFEYNLIP
What are the official names of this protein?
Putative B3 domain-containing protein At2g21920.
What are the subcellular locations of this protein?
Nucleus.
Protein: MYD88_GORGO
Sequence: MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLEIRQLETHADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP
What is the function of this protein?
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.  Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Increases IL-8 transcription.  Involved in IL-18-mediated signaling pathway.  Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes.  Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity).  MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
What are the official names of this protein?
Myeloid differentiation primary response protein MyD88.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS20_BRUA2
Sequence: MANTPSAKKAVRKIAARTEINKSRRSRVRTFVRKLEDALLSGDKQAAEVAFKAVEPELMRAASKGVVHKNTAARKVSRLAKRVKALNA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: ZN260_RAT
Sequence: MLESLQPESELLHDEPDPGEKVYECDECRKTFSLEQHFVEHKKTHGGEKSPECTGCGEEFSKASSLTRHLRSRSRRESYKCGNCGRTFSQRGNFLSHQKQHAEERPSESKKTPVPMTTIVRNQRNAGNKPYACKECGKAFNGKSYLKEHEKIHTGEKPFECNQCGRAFSQKQYLIKHQNVHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKSNLTEHEKIHIGEKPYKCNECGTIFRQKQYLIKHHNIHTGEKPYECNKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQSSSLTVHMRSHTGEKPYGCNECGKAFSQFSTLALHMRIHTGEKPYQCSECGKAFSQKSHHIRHQRIHIH
What is the function of this protein?
Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling.  Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA.  Also acts as a cofactor with GATA4, a key cardiac regulator.
What are the official names of this protein?
Zinc finger protein 260, Zfp-260, Pancreas-only zinc finger protein 1, POZF-1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS18_CAMJD
Sequence: MAEKRKYSRKYCKYTEAKVEFIDYKDTAMLKHALSERFKIMPRRLTGTSKKYQEMVEVAIKRARHVALIPYIVDRKEVINNPFEGL
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: Y600_STRA3
Sequence: MSQEKLKSKLDQAKGGAKEGFGKITGDKELEAKGFIEKTIAKGKELADDAKDAVEGAVDAVKEKLK
What are the official names of this protein?
UPF0337 protein gbs0600.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: RPOB_CERS4
Sequence: MAQSYVGQKRIRRYYGKIREVLEMPNLIEVQKSSYDLFLKSGDGPKAADGEGIQGVFQSVFPIKDFNETAVLEFVKYELEKPKYDVDECQQRDMTYAAPLKVTLRLIVFDVDETTGARSVKDIKEQDVYMGDMPLMTANGTFIVNGTERVIVSQMHRSPGVFFDHDKGKTHSSGKLLFACRIIPYRGSWLDFEFDAKDIVFARIDRRRKLPVTTLLYALGMDQEGIMDAYYETVNFKHQKNRGWVTRFFPERVRGTRPTYDLVDAATGEVILKAGEKATPRMVKKWIDEAQITELLVPFDHIVGRYVAQDIINEETGEIWVEAGDELTMEYDRDGEVKGGTLKLLLDQGITDIPVLDIDNVNVGPYIRNTMAADKNMGRDTALMDIYRVMRPGEPPTVEAASNLFDTLFFDSERYDLSAVGRVKMNMRLDLGKPDTQRTLDRDDIIACIKALTELRDGKGEIDDIDHLGNRRVRSVGELMENQYRVGLLRMERAIKERMSSVEIDTIMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRMCPIETPEGQNIGLINSLATFARVNKYGFIETPYRKVVEGAVTDDVVYMSATEEMRHTVAQANAQLDEEGRFVSDLISSRKAGEFMLNPPDAIDLIDVSPKQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLQSDAPFVGTGIEAVVARDSGAAIMARRAGVIDQVDATRIVVRATEMLEPGEPGVDIYRLRKFKRSNQSSCINQRPLVKVGDVVHRGEVVADGPCTDMGELALGRNVIVAFMPWNGYNYEDSILISERILRDDVYTSIHIEEYEVAARDTKLGPEEITRDIPNVGEEALRNLDEAGIVYIGAEVQPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGAYGTIVEVRVFNRHGVDKDERALQIEREEVERLARDRDDELAILERNIYSRLRTLIMGKTAVKGPKGIRAGSEINEDLLSTLSRGQWWQLALGEEADAKEVEALHEQFEAQKRALDHRFEDKVEKVRRGDDLPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVISKVVPIEDMPFLADGTHVDLVLNPLGVPSRMNVGQILETHMGWAARGLGIKIDEALQDYRRSGDLTPVKEAMRLAYGDETYEGAFGDREDEDLVEMAGRVTKGVPIATPVFDGAKEPDVNDALRRAGFDQSGQSIVFDGRTGEQFARPVTVGVKYMLKLHHLVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRLGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKMYESIVKGEDNFEAGVPESFNVLVKEVRGLGLNMELLDADEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: H2B_ENCCU
Sequence: MAKSARHVTGKAPSSLDAHDRKKSKKKSSSMCVGSMFKSAVKRISREVSPDNNIMLTSNSIQVLCGISYDFVDTVADLAGELARKVGKQTVGSDDIISAFEILLKGELRKLAIREVHNALSKSQAKSRGK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: EPS8_MOUSE
Sequence: MNGHMSNRSSGYGVYPSQLNGYGSSPPYSQMDREHSSRTSAKALYEQRKNYARDSVSSVSDVSQYRVEHLTTFVLDRKDAMITVEDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTISHCQAVVHACSYDSILALVCKEPTQSKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRRPEALRMIAKADPGIPPPPRAPAPVPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKSKKSKRKGPGEGVLTLRAKPPPPDEFVDCFQKFKHGFNLLAKLKSHIQNPSASDLVHFLFTPLNMVVQATGGPELASSVLSPLLTKDTVDFLNYTATAEERKLWMSLGDSWVKVRAEWPKEQFIPPYVPRFRNGWEPPMLNFMGAPTEQDMYQLAESVANAEHQRKQDSKRLSTEHSNVSDYPPADGYAYSSSMYHRGPHADHGEAAMPFKSTPNHQVDRNYDAVKTQPKKYAKSKYDFVARNSSELSVMKDDVLEILDDRRQWWKVRNASGDSGFVPNNILDIMRTPESGVGRADPPYTHTIQKQRTEYGLRSADTPSAPSPPPTPAPVPVPLPPSVPAPVSVPKVPANVTRQNSSSSDSGGSIVRDSQRYKQLPVDRRKSQMEEVQDELFQRLTIGRSAAQRKFHVPRQNVPVINITYDSSPEEVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRSVCPEGARVFNQITVQKAALEDSNGSSELQEIMRRRQEKISAAASDSGVESFDEGSSH
What is the function of this protein?
Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture.  Depending on its association with other signal transducers, can regulate different processes.  Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity.  Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context.  Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction.  Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions.  Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion.  Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity.  In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation.  Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core.  Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.
What are the official names of this protein?
Epidermal growth factor receptor kinase substrate 8.
What is the protein family that this protein belongs to?
Belongs to the EPS8 family.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cell projection, ruffle membrane. Cell projection, growth cone. Cell projection, stereocilium. Synapse, synaptosome. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells (PubMed:24741995, PubMed:23918390). Localizes to the midzone of dividing cells.
Protein: HACB_THET2
Sequence: MPRVWKFGDQINTDDILPGKYAPFMVGEDRFHLYAFAHLRPEFAKEVRPGDILVFGRNAGLGSSREYAPEALKRLGVRAIIAKSYARIFFRNLVNLGIVPFESEEVVDALEDGDEVELDLESGVLTRGEERFALRPPPPFLLEALKEGSLLDYYKKHGRFPGE
What is the function of this protein?
Catalyzes the reversible hydration of cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate) to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate).  Can catalyze neither the dehydration of (R)-homocitrate ((2R)-2-hydroxybutane-1,2,4-tricarboxylate) into cis-homoaconitate in vitro, nor the reverse reaction.  Is not active toward (S)-homocitrate, cis-aconitate or citrate as substrate.
What are the official names of this protein?
Homoaconitase small subunit, HACN, Homoaconitate hydratase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family.
Protein: NOD3_PEA
Sequence: LLMVLGFFFATYNLVSMIVGHKVGSDLGSIVDGKVEFTNTKSKFHVAVTATDAAYSQWQCRIMYYWYKKAKDMPGSAMGKFTRILHSGKEDQLMNEIPTFVVDPLPDGLDRGYIVLNRPWAFVQWLEKAVIDEEYILMAEPDHIFVNPLPNLASENEPAGYPFFYIKPAENEKIMRKFYPKEKGPVTDVDPIGNSPVIIHKYLLEEIAPTWVNVSLRMKDDPETDKVFGWVLEMYAYAVASALHGIKHTLRKDFMLQPPWDLEVGKTFIIHYTYGCDYNLKGKLTYGKIGEWRFDKRSYLMSPPPKNISLPPPGVPESVVRLVKMVNEATANIP
What is the function of this protein?
Probable glycosyltransferase involved in the O-arabinosylation of several proteins including extensins and small signaling peptides (By similarity).  Catalyzes the transfer of the initial L-arabinose to the hydroxyl group of Hyp residues (By similarity).  Probably involved in the arabinosylation of CLAVATA3/ESR-related (CLE) signaling peptides that move from root to shoot, to interact with receptor kinase signaling that regulates nodulation (By similarity).  Involved in long distance nodulation signaling events (PubMed:21742814, PubMed:21802605).  Involved in the autoregulation of nodulation (AON), a long distance systemic signaling from root to shoot and back again, which allows legumes to limit the number of root nodules formed based on available nitrogen and previous rhizobial colonization (PubMed:21742814, PubMed:21802605).
What are the official names of this protein?
Hydroxyproline O-arabinosyltransferase NOD3, Protein NODULATION 3, PsNOD3.
What is the protein family that this protein belongs to?
Belongs to the RDN family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: MURD_MACCJ
Sequence: MKHIQKYQGKKVLVLGLGKSGYETAKLLYRLGAQVTVNDGKDVSQTEQYRELTEMGITVIGGHHPLSLLEHTTLIVKNPGIPYTLSLIEQAQTMNIPIITEVELAYEITESSILGITGTNGKTTVTSLIGDMFKAHEHAGLLCGNIGFVASKVAQNAGAHDTLVMELSSFQLMGIQEFRPHIALITNIYSAHLDYHGNQQNYIDAKMQITKNQTSEDYLIFNDKQRTLLQNYNIKSKVVYFSTDEKVEGAYIDQNKVYFYDEFIIDVKDIVLPGVHNLENVLASIAAAKLAGIDNIHICDTLKTFEGIKHRLQFVTETDGVKYYNDSKATNTLATSFALDSFHQPTHWLAGGLDRGNGFEELDTHIDHVKHMYIFGETTEKLTAFAAQHHIPYTICKDVTDAVLKTASYVERGEVVLLSPACASWDQYPTYEVRGEHFISQVKLI
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHI2_DANRE
Sequence: MEDFAVSFWIYIGVMSIFVGGAVKKFLAFNIGAMPSVVVWLGATLLVERLCALCMPAVLARLVLCVCCWLYFTWATPKPSLPVEDKAVFITGCDSGFGNATAKKLDAMGFEVFATVLNLEGEGAKHLRKVCSSRLTLLQVDITQPQQVQQALLDTKAKLGIRDLWGLVNNAGWCVNIGDAELSLMSNYRGCMEVNFFGTVTVTRTFLPLLRQSKGRIVTISSPSGEHPFPCLASYGASKAALNLFINTLRHELDPWGVKVSTILPSAYKTGQSSNAEYWEKQYKSLLQGLSPNLLEEYGEEYLLETKELFQNYAKTANEDLSPVIDTIVEALLSPQPQVRYYAGPGLILMYFICSYLPLSISDRFLQKLFVQKKVMPRALIKQQGLSPNDNNNSIKENMNDSSSNNSNFTKCID
What is the function of this protein?
Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:22796344, PubMed:23042946, PubMed:27927697, PubMed:33387577).  Cortisol is the primary glucocorticoid in teleosts and is released to increase glucose bioavailability in order to meet the increased energy demands in response to stress (PubMed:23042946).  Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, regulating the hypothalamus-pituitary-interrenal (HPI) axis function in adult fish (PubMed:23042946).  Decreasing the excess glucocorticoids may be of relevance to brain function and neural proliferation (PubMed:23042946).  Plays a key role by catalyzing the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), the major fish androgen, that activates androgen receptor transcriptional activity (PubMed:22796344, PubMed:27927697).  Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (PubMed:27927697).  Exerts a dual role in fish by inactivating glucocorticoids and activating androgens (PubMed:22796344, PubMed:27927697).
What are the official names of this protein?
11-beta-hydroxysteroid dehydrogenase type 2, 11-DH2, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type II, 11-HSD type II, 11-beta-HSD type II, Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.