PharMolix/UniProtQA huggingface dataset:
Protein: Y1743_METLZ
Sequence: MPTISTAECFTHGKVANELHAFARGYPHEYLFSIDRKKVDISVVAGMFIPTLTGVRTLLHFEPLEPRLVIDTVKVYEQDQDCIMACRMAEAVMRVTGADIGIGTTAGIGKGAVAIASQDKIYSKVTRIDADFRTSDAKKLMQREKSGVFTALRLFEEFLLEGEFPDSYNKYI
What are the official names of this protein?
UPF0254 protein Mlab_1743.
What is the protein family that this protein belongs to?
Belongs to the UPF0254 family.
Protein: FTHS_DESRM
Sequence: MKKVPSDLEIAQAHEMIPIAEIAKNIGLGEDDIDLYGKYKAKISLDVLRKFNDRAMGKLIDITAITPTPLGEGKTVTTIGLCQGLGKIGKKVITTLRQPSMGPVFGIKGGAAGGGYSQVVPMEDINIHFTGDIHAVEAANNLLAAMIDTSILLGNPLNIDPMTVMWNRVLDTNDRALRDIVVGLGGKENGYPRQTSFDMAVASEVMAILALAENLHDLRQRLGRIIVAYTYDGKPVTAEDLKAAGAMTVIMKEALKPNLVQTLEGQACIMHAGPFANIAHGNNSVLADKIALNLADYVVTESGFGSDLGMEKFMDIKCRQSGLRPSCVVITCTIRALKMHGGLGNVVAGKPLPEELTRENLPALEKGCANLAHHIKVASYYGVPVVVSINRFTPDTDAEVDLVRKKALEAGALGAYPITVWAEGGEGAIELAEAVVAACEKTADFQLLYPDNLSIKEKIEVLATKVYNADGVVFEPLAERKIKQFEDLGLGHLPICMAKTHLSISHDPAMKGLPKNYIFPIRDIRASVGAGFLYPLAGAMRTMPGLGSKPAAHNVDIDEYGRTVGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: MNMG_DECAR
Sequence: MLYPTRFDVIVVGGGHAGTEAALAAARAGANTLLLTHNLDTLGAMSCNPSIGGIGKGHLVREVDALGGAMAAATDEAGIQFRILNASKGPAVRATRAQADRVLYKQAIRTRLENQPNLTIFAEACDDLIVEGDKVCGAVTQLGIRFMAEAVVLTAGTFLNGKIHVGLENYTGGRMGDPPSVSLASRLKELKLPQGRLKTGTPPRLDGKTIDFSVMEEQHSDDPLPVFSFLGNAAQHPKQLPCWITETNERTHDIIRSGLDRSPMYTGVIEGVGPRYCPSIEDKIHRFADKNQHNVFLEPEGLTTHEIYPNGVSTSLPFDIQLALVRSIRGMENCHILRPGYAIEYDFYDPRGLKDTLETKAIHGLFFAGQINGTTGYEEAAAQGLLAGINAVRYVRGQSGWCPKRNEAYLGVLVDDLITRGVSDPYRMFTSRAEYRLSLREDNADLRLTEQGRELGLVDDVRWTAFCQKRDAIAAEQERLKSTWVNPKITPADDCIRVLGKAIDHEYNLFELLRRPEVTYTSLLTLPGAGEAQTDPLVVEQLEISAKYQGYIDRQAEEVAKSSSYENTVLPSELDYSSVAGLSNEVRQKLAQHKPQTIGQASRIQGITPAAISLLLIHLKRHNLSQAA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTXL_MESEU
Sequence: TEAMCMPCFTTDHNMAKKCRDCCGGNGKCFGYQCLCNRG
What is the function of this protein?
Inhibits Kv1. 2/KCNA2 potassium channels.  On glioma cells, may interact with chloride channels (probably Clc-3/CLCN3) and MMP2 at the surface of glioma cells.  This complex may be then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation.
What are the official names of this protein?
Chlorotoxin-like peptide MeuClTx, Chloride channel toxin-like peptide.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSD_AGRFC
Sequence: MNLFDTIRNTIVPIHKEGYVFVAAFFVASLVLGWIAEPLFWVGLVLTAWCAYFFRDPERVTPQDDDLIISPADGKVSAVQSVVPPLELELGKEPMVRISVFMNVFNCHVNRAPVRGRIVNVAYRPGLFLNAEVDKASEDNERNGLVIETSHGKVGVVQIAGMVARRIVCWVKPNEPVDAGERFGLIRFGSRLDIFLPAGFEPRVSVGQTAIAGETVLAEFGSAKGPVLSRRG
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GREA_METS4
Sequence: MDKVPITIRGYAALEEELKHRQQVERPRIIQAIAEARALGDLSENAEYHAAKEAQSLNEGRVLELESLISRAEIIDVSKLSGTKVKFGATVQLIDEDTEEEKTYQIVGEPEADVRSGRVSITSPVARALIGKGVGDTVEVTTPGGGKSYEIVGIRYVG
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: UBIE_ECODH
Sequence: MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: NANT_ECO45
Sequence: MSTTTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQGEFGLTTVQAASLISAAFISRWFGGLMLGAMGDRYGRRLAMVTSIVLFSAGTLACGFAPGYITMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHGGKAPVRTMVDILYRGEHRIANIVMTLAAATALWFCFAGNLQNAAIVAVLGLLCAAIFISFMVQSTGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTDLAYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDGKPFSGAVPFGSAKNDLVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ALL6_CYDPO
Sequence: LPLYNFGL
What are the official names of this protein?
Cydiastatin-6.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL19_STACT
Sequence: MSNHKLIEAVTKSQLRTDLPTFRPGDTVRVHVRIVEGTRERIQVFEGVVIKRHGGGISETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYLRNLRGKAARIKEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: GUAA_DESVV
Sequence: MDAQTKVIIIDYGSQVTQLIARRVREAGVYSEIHPCIVTAEQVRAMKPAAIILSGGPASVGEKDAPALEKGLLDLGVPVLGICYGMQLLGQDLGGELATSETREYGPADLTLTAPCPLWDGLDLGTTSRVWMSHGDKVKTPPPGFKVVGRTATLEVAAMADEARRIYAVQFHPEVHHSEDGARIINNFLFHVAKLKADWTMSSFVERAVKEMAEVVGDRHVVCALSGGIDSTVVAVLLHKAIGKQLHCIFVDNGVLRLNEGQEVVDYLREHFDLNLKYVQAQERFLSKLHGVDDPEQKRKIIGYTFIEVFDEEAKALGHVDFLAQGTLYPDVIESVSHKGPSAVIKSHHNVGGLPEKMNLKLIEPLRELFKDEVRKVAAELGLPDFIIWRHPFPGPGLAIRVIGEITEERLDILRRADKVVQQELMSSGWYRKVWQGFAVLLPLKTVGVMGDGRTYEHVIALRIVDSVDAMTADWARLPSELLERISSRIINEVKGVNRVVYDISSKPPSTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: HISX_BURL3
Sequence: MSITIRKLDSTSAGFGAELRALLAFEASEDAAIEQSVAQILADVKSRGDAAVLEYTNRFDRLSASSIAALELPQDALQTALDSLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTESDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDMIAGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDGAFLERVEKAIDELLPSMPRQDVIRASLEGRGALIKVRDMAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSAEGAQTLGEIASELAYGEGLQAHAKSAEFRMKH
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: GYRA_HALL2
Sequence: MSSDAPDSFEPGAGIAAEVKNARIEDEMEQSYIDYAMSVIAGRALPDVRDGLKPVHRRILYAMHQAGVTSNSSHRKSSSIVGETMGDYHPHGDSAIYDTLARMAQDFSMRYPLVDGQGNFGSVDGDPPAAMRYTEARMSPIAEELLDDIDKDTVDFQSNYDDRKQEPTVLPSSFPNLLVNGSSGIAVGMSTNIPPHNLGEVVDATVELIENPDATVADLMEHIKGPDFPTGANIVGRNAVHKAYKTGRGRVRVRADYDVFEEEGRIVINELPYQENKARLIERIADDVNEGKIEGIRDIRDESDRDGIRVVIELKRGAMAEVVKNQLLDNHLESTFGVINLALVDGQPQVLTLKETLEHYLDHRRDVVRRRSEYELAEAEDRAHILDGRLKALDNIDDVVETIRNSESRDDAKAALRGEVEVEVDGEPLPTFDFSEEQANHIVSMQLGSLTSMEAAEIEAEYEDVQATIERLETILGDQSELDAVIESELLDIKDEYADDRRTSFVANTGEVTRADLIPEEDVVVVVSEDDYIKRMPVSRFRAQHRGGKGIIGTDLKEGDNVSSVFVTNTHDDLLCFTNHGQVYQLKAYQVPEMSRTARGKSAVNLLDFDDGEEITAVVNCDDLEDIEGYLTMVTRNGYIKRTGTDRFQNILSTGIIATKLDEGDELVDVEVTDGESDLVIGTERGMSIRFDEDEVRAMGRSARGVRGIKLEGDDVVAGVAAIDEAHHSWILTVTENGYGKRTDLDAYRTQSRNGKGLIDIKANERNGPVCAINTVGEGDHLVVMSDEGQILRTPVEDISTVGRNTMGVIVMDLDEGDAVASVDVIPAAMTTEAEELDDADSVEEDAETDAKADADDE
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AG103_ARATH
Sequence: MASSSSSSLSFSTSKKNKTFFKKPNSAFSSSRATSLIKRQQTVFKKAKELSILCDIDVCVICYGSNGELKTWPEEREKVKAIARRYGELSETKRRKGSVDLHEFLEKMNKDDPEKEEKKKIKVRRVPKVKYPVWDPRFDNYSVEQLMGLVQSLERNLTRIQHRTCAVVEAQGQRRVQYTNMANQELMMANTMNQLQQHSNQVSMYLWNHGNGAFSQIPVSALASNQTQSLAPIPPELMIYPNSDAGNYSGSLGVQGTGINGLQNMNMLTYNNINSVNDFSKQFDQNSRAESYSSLLGVHEDGNNEFENPNMSSRNNFNVQDCAGLLGMQGAGTNGLQSMNMHDYSNNNSINSNGLSHQYVQFPTYNSQHQDRVFNLDQNGNNTRSL
What is the function of this protein?
Probable transcription factor that may function in the maintenance of the proper function of the central cell in pollen tube attraction.
What are the official names of this protein?
Agamous-like MADS-box protein AGL103.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARNC_PSEAE
Sequence: MKPYPIDLVSVVIPVYNEEASLPELLRRTEAACLELGRAFEIVLVDDGSRDRSAELLQAAAERDGSAVVAVILNRNYGQHAAILAGFEQSRGDLVITLDADLQNPPEEIPRLVERAAQGYDVVGSIRAERQDSAWRRWPSRLVNLAVQRSTGVAMHDYGCMLRAYRRSIVEAMLACRERSTFIPILANGFARHTCEIRVAHAERAHGESKYSAMRLLNLMFDLVTCMTTTPLRLLSLVGGGMALAGFLFALFLLVLRLAFGAAWAGNGLFVLFAVLFMFSGVQLLGMGLLGEYLGRMYSDVRARPRFFIERVVRATPSALPSALQRAGFTSSSSEPSTP
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TILS_BEUC1
Sequence: MSGPHPSVAAARNAVRALLAELEPARGVLVACSGGADSLALAAATAFVAPRAGRAAGAVVVDHALQAGSAEVAARAADQCRGLGLEARVVRVDVDIALGGPEGAARAARYAALEAASREAGDAVVLLGHTLDDQAETVLLRLARGSGARSLAGMPRRRGVFARPFLHLERARLREVVDAVGLTPWEDPTNAVDGPARRADGGPLPRSAIRGRVLPALTEALGPGVPASLARSADLLREDADALDAFAADLLSTARGEDGSLDVEILAAAPPAVRRRALRRAALDAGSPAGDLAHVHVEALDALVTGYHGQAGVDLPGGRRAVRACGRLTL
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA1_SHEFN
Sequence: MKLAPDLLQATFEQTFSILQQARRSFSPQLQPREIGTITSIATGIAKVSGLPGVGFEEILKFPSDIFGIAFNVDEDEIGAVLLGDYWHLQAGDEVERCGHLVDVPVGEGLLGRIINPIGEPLDGKGRLIASARLPIERPSPAIMNRAPVSVPLQTGIKVIDALIPVGLGQRELILGDRQTGKTAIAVDTILNQRDKNVLCVYCAIGQRASGVAKVIATLHEQGALEYTVVVVTEGNDPPGLAYIAPYAATSIAEYFMQQGRNVLIVYDDLTHHARAYRELSLLLRRPPGREAFPGDIFYIHSRLLERATHLSPNLGGGSLTALPIIETEAQDISAYIPTNLISITDGQIYLSPSLFELGVLPAIDVGKSVSRVGGKAQRAAYRAVASNLKLAYAQFEELETFASFGARLDDSTLKTIDHGRRIRACLKQAESTPISMIEQIAVLLALTANLFDEVPLDVMSQAEHAVRAATADIPVEITARLASTEKLTDEDRDGILQPVRDALAPFMHSQKRKEIT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 1, ATP synthase F1 sector subunit alpha 1, F-ATPase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TRXR_ARTBC
Sequence: MGVQRLALALIAFTSALTSVIAAPIVIEQPPLGPEHRYDAIVIGGGPSGLSALSSLGRVRRHVLLFDEGIYRNGATRHIHDMLTNDGVEPKVFRAKARQQISRYTSTSIKDVKVTKIKKVFEHGGRKYFFQVTDKTGAMYTASKVVLGTGVLDVLPGTPGLQENFGKGIYWCPWCDGWEHRDQPLGILGPLRHVMDSVYELETLNNDIIAFVNGTEHSVEDILYLNRKYPHWRQQLKHYNVQINNKMVSSIDRLQDGSKHQDKKTWQEFDKFRVNFNDGTSVERSVFITNFPTEQHSDLPDQLGLARDPIHKNKIKVNFKGMRASVPGVFVVGDANNDGSTNGNHAMFSGKRAAVALHVELEQERAEAALGKRDESFSAEQVENEALKLIGRDTEELEELWGRK
What are the official names of this protein?
Probable thioredoxin reductase ARB_06224.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Secreted.
Protein: CASP4_ARALL
Sequence: MKSDSIAVDVPAESSSAIKGKAPLLGLARDHTGSGGYKRGLSIFDFLLRLAAIVAALAAAATMGTSDETLPFFTQFLQFEASYDDLPTFQFFVVAIAIVTGYLVLSLPFSVVTIVRPLAVAPRLLLLVLDTAALALDTAAASAAAAIVYLAHNGNTNTNWLPICQQFGDFCQKTSGAVVSAFASVTFLAILVVISGVSLKRP
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 4, AlCASP4.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: STL1_STRTC
Sequence: MDHALFRNLFGGFMNVRTLRSYQLLPSYEVLELPTNIIHAPPPNRFRRKPLQFAARILSSPLLRRALTIAILLPILYVLSGGIPPTYSDIHQFETNLPQHRTSGVDRRYLRFEGTLWGLGLNNILQEQLLLSYIAYASNRSFVFSDYTWSQLPLPYTLYDGALRPTHMPLNTFISAPTAGGDMPSIALTQDVFDEASMSGGPSPHDIRAVHLSHFDSVCPTSARVRLSSAAEERLSDDSLDGAELLNTWVEWLNNASDDPCLVVDFADKPVFNHLLFGSERVISMYPLLASTPILRDFKWSSLVQSAVDRNMEEIEKSADAAADVIPGLVAVHLRRGDYDGHCRYLAKWAIPYQGMNRFPGIVDTLDPEDFDHETESESAQLDHYLRHCLPDITQIVDRLREVRDESPELNLEKVYLLSNGDEWWLNELWEELEKDGWSPVEEGMTSSQDLDITNEEQYISGAIDMAIAEQAEVFIGNGFSSLSGNIIMFRMAKGVPVGSNRLL
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of strobilurin A, an antifungal polyketide that contains a key beta-methoxyacrylate toxophore that targets the complex III of the mitochondrial electron transport chain (PubMed:30258052).  Strobilurin biosynthesis begins with construction of benzoyl CoA by step-wise elimination of ammonia from phenylalanine by the phenylalanine ammonia-lyase str11, oxygenation by str8 and retro-Claisen reaction to form benzoic acid, which is activated to its CoA thiolester benzoyl CoA by the dedicated CoA ligase str10 (PubMed:30258052).  Benzoyl CoA forms the starter unit for the highly reducing polyketide synthase stpks1 that produces the polyketide prestrobilutin A (PubMed:30258052).  The FAD-dependent oxygenase str9 then catalyzes the key oxidative rearrangement responsible for the creation of the beta-methoxyacrylate toxophore (PubMed:30258052).  Str9 performs epoxidation of the 2,3 olefin of prestrobilutin A, followed by Meinwald rearrangement to furnish the aldehyde intermediate (Probable).  Rapid enolization of the aldehyde intermediate would give the beta-methoxyacrylate skeleton and methylations catalyzed by str2 and str3 complete the synthesis and lead to the production of strobilurin A (Probable).  The short-chain dehydrogenase stl2 and the dehydrogenase str4 play a role in the shunt pathway leading to the production of bolineol (PubMed:30258052).  The cluster encodes no obvious halogenase gene that could be involved in production of strobilurin B, nor any obvious dimethylallyl-transferase that could be involved in the production of strobilurin G (Probable).  It is possible that unknown proteins encoded in, or near, the cluster (such as str1 or stl1) may form new classes of halogenases or dimethylally-transferases, or that the responsible genes are located elsewhere on the genome (Probable).  Similarly, proteins encoded by str5/str6 hydrolases appear to have no chemical role in the biosynthesis of strobilurin A (Probable).  Finally, no obvious self-resistance gene is found within the cluster (Probable).
What are the official names of this protein?
Strobilurin A biosynthesis cluster protein l1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL30_ECO27
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAIRGMINAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: Y1428_METJA
Sequence: MNLFRKISEKLKSYEDWVTEANYYLDEGIYDKAVECYLKALEKKNTNPIDWFNLAYALYHLEKYDSALEAINEALKISPSNIYFAYLKGLIHYKRGEIILAYKYLKKASEKIKNEELFEILGDISVKYGRYEEALKYYLKSYKMANSKNLNALFKAGKIYLLFGDIDKAYDAFNEILQQNPSHECKKIVECMENVVNAINSYEDLNNGLTMIKNKDYIGALKIFNKVLQIDENSDISYYYKSVIAEIFEEYKKALEYIDKSISIFNRSLYYAKKGDILYKLGDEEGAIEAYNKAIKLNSQNPYAYFGLAILYYRKGELEKSSNFFDKVLETYLEELSEEDISALNLYSLIGKAETTGIPKYYHEAMKYVDNLINLENSSRWWYVKGYIYYKLGNYKDAYESFMNALRVNPKDISTLKSLAIVLEKSGKIDEAITTYTKILKIVNSLQFTCEIDNILEKLRSRKPTNLEIPSVLFDIPVMYHKPNITCFYASNLWKYMANNNPIGAYIYLSFIESYISLDEISQMVNDIKSKLSLEMYRYCELIDDYKSDESVLMQIKELLQKLGCML
What are the official names of this protein?
TPR repeat-containing protein MJ1428.
Protein: DAP_BRUO2
Sequence: MPNIDLPTLEAFVHAIPQNYKGPGGAVAVVRNGEIVLRHAWGFADLAARKAMTPETRMPICSVSKQFTCAVLLDCIGEPEMLDSALAAYLDQFGDGRPAVRDLCNNQSGLRDYWALTVLCGAAPEGIFLPDQAQNLLRRLKTTHFAPGTHYSYCNGNFRILADLIEQHTGRSLADLLAERIFAPAAMKTAELIPDTALFNECTGYEGDTVHGFLPAINRIHWLGDAGICASLDDMIAWEQFIDRTRHDENGLYRRLSSPQTFADGAPAPYGFGLKFEETGGKRLTGHGGALRGWRCQRWHCADERISTIVMFNFEGNASDAALKMMNAALGIPPAKPVRAQANPGWFGSWLNPETGLVLSLEDAGGGRMKARFGTGPEIMDISGENEAQSSMTTLRRDGDMIHLARKDENLHLAMHRLKGEARQDIAGRYRSDELEADLLLVSEGGAIYGAFEGFLGKSDMYPLYAAGPDVWLLPVQRSMDAPSPGEWKLVFHRDAAGRITGVTVGCWLARGVEYKRL
What is the function of this protein?
Hydrolyzes N-terminal residues in D-amino acid-containing peptides.
What are the official names of this protein?
D-aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S12 family.
Protein: PLSX_SYNWW
Sequence: MRIAVDAMGGDYAPLEIVAGAVKWVAEEEERQIFLVGQEELLKQELKSYSYDPSRLIVVNASEVITMEESPATAIRRKKDASIVVASRMVKEKKADAIISCGSTGAQMAAAIFILGRMEGIERPPIVASIPNMTGAYTLLIDVGANVDCKPRQLLQFALLGKTYASIIYGVEQPRVALLNNGEEESKGNTVTMETYALLRQQSGINFTGNVEGRDIFTGKSDVIVCDGFTGNVLLKTMEGMALFIAQGILGAGGPMPAFFQRLDYTQTGGAPLLGINGLSIVCHGSSKREAVYNGLRIAEDCYNKNIIEMQQLELSKISG
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: APOV1_MELGA
Sequence: KSIFERDRRDWLVIPDAVAAYIYEAVNKMSPRAGQFLVDISQTTVVSGTRNFLIRETARLTILAEQLMEKIKNLWYTKVQGY
What is the function of this protein?
Protein component of the very low density lipoprotein (VLDL) of egg-laying females.  Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes.
What are the official names of this protein?
Apovitellenin-1, Apovitellenin I.
What is the protein family that this protein belongs to?
Belongs to the apovitellenin family.
Protein: SK1_ARATH
Sequence: MEAAITQRIQYPSWVDCRKVECKPQRGSLRYSQQVKVDRRFRGLSLARLQPERRNDQRRAVSPAVSCSDNNSSALLETGSVYPFDEDILKRKAEEVKPYLNGRSMYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQAMNGTSVAEIFVHHGENFFRGKETDALKKLSSRYQVVVSTGGGAVIRPINWKYMHKGISIWLDVPLEALAHRIAAVGTDSRPLLHDESGDAYSVAFKRLSAIWDERGEAYTNANARVSLENIAAKRGYKNVSDLTPTEIAIEAFEQVLSFLEKEETMEIPDGDL
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 1, chloroplastic, AtSK1.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ESTR_MYCTO
Sequence: MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGFGLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQDFRTFDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIEANFRTYAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAVLDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFDSVNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGAAAERAD
What is the function of this protein?
Exhibits lipolytic activity with medium chain length esters as optimum substrates.
What are the official names of this protein?
Esterase MT1326.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Cell wall anchored. Binds peptidoglycans via the LytM domains.