PharMolix/UniProtQA huggingface dataset:
Protein: RL22_SHEAM
Sequence: MEVLAKHRFARTSPQKARLVADQIRGLPVAKALEILTFSPKKAAVLVKKVVDSAIANAEHNEGADIDDLKIAKVFVDEGPTMKRIMPRAKGRADRIIKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: HOA1_BURL3
Sequence: MNDARKKLYISDVTLRDGSHAIRHQYSIANVKAIAAALDRAGVDSIEVAHGDGIEGSSFNYGFGAHSDVEWIEAAAASVKHAKIATLLIPGIGTIHDLRNAYDAGARVVRVATHCTEADVSRQHLEYAREIGMDPVGFLMMSHMTTPQKLAEQAKLMESYGATCVYVVDSGGALGMNDIRDRFRAFKEALKPETQTGMHAHHNLSLGVANSLVAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAAERQGWHHGCDLYGLMDAADDIVRPLQDRPVRVDRETLALGYAGVYSSFLRHAERAADKYGLKTVDILVELGRRKMVGGQEDMIVDVALDLLKSAEHERTHAEPTMSEAGR
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 1, HOA 1, 4-hydroxy-2-keto-pentanoic acid aldolase 1, 4-hydroxy-2-oxopentanoate aldolase 1.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: MURB_STRPD
Sequence: MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNHYELSRIVVYANKENMPWLVLGNASNLIVRDGGIRGFVIMFDKLNAVHLNGYTLEAEAGANLIETTKIAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEISHIFLSAKVLTSSGEIKTISARDMAFGYRHSAIQETGDIVISAKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSVFKRPPGHFAGQLIMEANLKGHRIGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETVENHSGVRLEPEVRIIGENL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_PYRAE
Sequence: MSTLEEVLSEAYKLVIPSEEEEKRIREVTQKVKRLVSQIIEEGGIDALVDVYGSGARGTWLPGQRDIDIFVVLNDRRIKPEDVVKILTSRFTTLGLNWALRYAQHPYVSLQVDDYEVDIVPCYKIQPGERPITAADRSPLHHKFLSERLKKDQILDVRLLKLFLKTIGVYGAEIKTEGFSGYLTELLVVYYGSFIEVLRAASRWRPYKTYITFVETSAKFKSPLVVVDPVDPNRNAAAAVSLTSMSTLILAARRFLKKPSLSYFQPSRGYAIRQVETVEVVYPYPGEPPDIVWGKYKRIGRNLFKWLRECGFKVFRWGVESDEKTYVKLVYVVEQTKLAPYTLHKGPPVYDDAVDAFIEKYVNEEVIGPFVVGARAYVIKKRKWTDISHCINAKLGKGNYDIRVNLYDGDLVRKTPWLT
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: CCMA_RHILO
Sequence: MRLIAENLGGERGGEAVFSGVGFALDQGQALVVTGPNGSGKSTLLRIIAGLLPKAEGRLLLENGGDDFPSIASACHYLGHQNAMKTALSVVENLRFWRDFNGRGDSGVEEALDTVGLGGVGHLPFGYLSTGQRRRAAIAKLLVSHRPLWLLDEPTAGLDKASEARFAGLMAGHCAGGGMIVAATHLPLGIEGAELRMGVAG
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BPTA_BORBU
Sequence: MGKILFFGLLLICIFLGFFFYKQKENNVIYNKIVEKFDDNVFVDETYTYLFKDSNLKELVFIKSQLIIPELKHKKMIKATGYRADAYKALSTVYRFDFKVHDNKILGFKSVIFEGFEDAKVSKHENNLPSEKWQQLKDFNIGDPNINEKFFHLEFPFVVKNTLCVTISKGFFKKIKKLKRLKIMLISNEDREYKIDIENFLPKYNL
What is the function of this protein?
Virulence-associated protein essential for survival of the bacterium within the tick host and therefore within the natural life cycle of the Lyme disease spirochete.
What are the official names of this protein?
Protein BptA, Borrelial persistence in ticks protein A.
What is the protein family that this protein belongs to?
Belongs to the BptA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: TRUB_EHRCR
Sequence: MYGWINLDKPCGISSASAVNLVKKILNVKKVGHAGTLDPLASGVLPIAIGEATKVMPYAVDVVKSYLFTVQWGEQRTTDDIEGKIVAKSDIVPSSEDIKKAIPNFIGLLRQVPPNFSAVHVNGVRAFKLARNGQDVSLTSRDVNVLKLKLLSADQENNKADFYLLCKKGVYVRSIARDLGIELGCLGYVRKLQRVRVGCFRKKNAITLEMLKMLYNNSRKCSYLLPLWYVLQDMKHLNDVFSDIQIKKIKNGQNIELNNLYVVRNCGICYVSTGNVPVAICSIVNSVVRPVRIFNV
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: SULA_ECOL6
Sequence: MYTSGYAHRSSSFSSAASKIARVSTENTTAGLISEVVYREDQPMMTQLLLLPLLQQLGQQSRWQLWLTPQQKLSREWVQASGLPLTKVMQISQLSPCHTVESMVRALRTGNYSVVIGWLADDLTAEEHAELVDAANEGNAMGFIMRPVSASSHATRQLSGLKIHSNLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: BSR_BACCE
Sequence: MKTFNISQQDLELVEVATEKITMLYEDNKHHVGAAIRTKTGEIISAVHIEAYIGRVTVCAEAIAIGSAVSNGQKDFDTIVAVRHPYSDEVDRSIRVVSPCGMCRELISDYAPDCFVLIEMNGKLVKTTIEELIPLKYTRN
What is the function of this protein?
Catalyzes the deamination of the cytosine moiety of the antibiotics blasticidin S, cytomycin and acetylblasticidin S.
What are the official names of this protein?
Blasticidin-S deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: YQGF_RHOBA
Sequence: MPTTTTTAEDGFPATGRLASVDYGTVRIGVAICDPDWILASPLEVHPVSTPEKDAQYFIDLAKSERIAAWVVGLPIHCDGGESDKSKESRKFAAWLKETTGLPTRLFDERFTTVAANAKIRQGKTTRKKTKQRVDAVAAQVLLESFLEACRYRGELAGHCLEDSTSDESLDDA
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPCM_RAT
Sequence: MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEISSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEDTRLATGLDGVRIENKGRISTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTFFAHFFIKF
What is the function of this protein?
Binds opioids in the presence of acidic lipids; probably involved in cell contact.
What are the official names of this protein?
Opioid-binding protein/cell adhesion molecule, OBCAM, OPCML, Opioid-binding cell adhesion molecule.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. IgLON family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: GGOP_MARAH
Sequence: MLLKNAVQLICYPDRIGNNLKDLYTVVDTHLSEAIGGLHILPFFPSNADGGFSPLTHKEVDPKVGTWDDIEAFTAKYDLCVDLTVNHISDESPEFTDFIANGFDSEYADLFVHVDKFGEISPDDMAKIHIRKEKEPFREVTLSDGTKTRVWCTFTEQQIDLNYESDLAYQLMESYIGFLTSKGVNLLRLDAFGYTTKRIGTSCFLVEPEVYQILDWVNQVALKHGAECLPEVHDHTSYQYAISRRNMHPYGFALPPLLLYSLLDANSTYLKNWLRMCPRNMVTVLDTHDGICIPDVEGVLPDEKIKVLIDNIDARSADPIMRRSAANIHSVGAIYQLTCTFYDALMQNDDAYIAARAIQFFTPGIPQVYYVGLLAGCNDHELMEQSGELRDINRHYYTLEEVEQDIQKPVVQRLLSLMKFRSNYPAFDGHFELNYSNNSSVAMAWRHGDYYCHLFVDLNFKTVKVTYTDVETGETRHLEC
What is the function of this protein?
Catalyzes the reversible phosphorolysis of 2-O-alpha-D-glucosylglycerol with retention of the anomeric configuration, forming alpha-D-glucose 1-phosphate and glycerol.  Has most likely a catabolic role, either regulating the intracellular levels of glucosylglycerol, which acts as a compatible solute, or degrading it when the environmental conditions change.  Cannot catalyze the phosphorolysis of sucrose or glucosylglycerate.
What are the official names of this protein?
Glucosylglycerol phosphorylase, GGoP, 2-O-alpha-D-glucopyranosylglycerol:phosphate alpha-D-glucosyltransferase, 2-O-alpha-D-glucosylglycerol phosphorylase (retaining).
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. Sucrose phosphorylase subfamily.
Protein: LEUD_MYCPA
Sequence: MEAFHTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFASWRSDPSFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDIFRGNAGKAGLLAAEVSQDGVELLWKLIEQSPGLEITANLQDRNITAGTTVLPFKIDDHTAWRLLEGLDDIALTLRKLDRIESYEATYPDWKPRTSPVA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RPOA_SHELP
Sequence: MQGSVTEFLKPRLVDIEQVNPTRAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSSKEGVQEDILEILLNLKGLAVVIEGKDEAMLTLSKSGAGPVTAADITHDGDVTIMNPDHVICHLTGNNDISMRIRVERGRGYVPASARAQTEDDDRPIGRLLVDSSFSPVARIAYNVEAARVEQRTDLDKLVIDMTTNGTIDPEEAIRRSATILAEQLDAFVELRDVTEPEQKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASLADDL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: VEGFA_PIG
Sequence: MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGDQKPHEVVKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEEFNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQENPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
What is the function of this protein?
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.  Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.  Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).  Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
What are the official names of this protein?
Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Protein: HMDH_XENLA
Sequence: MLSRLFRMHGQFVASHPWEVIVGTVTLTICMMSMNMFTGNDKICGWNYACPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSKASALAKFALSSNSQDEVRDNIARGMAILGPTFTLEALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFAFMTFFPACVSLVLELSRESREGRPIWQLSQFASVLEEEEDNKPNPVTQRVKMIMSLGLVLVHAHSRWISEPSSQNSTSISDHEVTTMLDDMMPKRVEPSMPLWQFYLSRMVTMDVEQIITLGLALLLAVKYIFFEQTETESTFSMKNPIISPVAVQKKQIESCCRREPEQEKTVHVSTTEEASSKEETEAVIKPLPLETSPKAKFIVGDSSPLELSPEDKNTMFDLPEEPRPLDECVRILKNPDKGAQYLTDAEVISLVNAKHIPAYKLETMMESPREGVAIRRQMLSDKLPQRSALQSLPYKNYNYSLVMGACCENVIGYMPIPVGVAGPLLLNNKEYQVPMATTEGCLVASTNRGCRAIMLGGGAKSRVLADGMTRGPVVRLPTACDAAEVKAWLDSAEGFKVIKDAFDSTSRFARLGRLQNCVAGRNLYIRFQSKTGDAMGMNMISKVTEQALARLQEEFPDLHVLAVSGNYCTDKKPAAINWIEGRGKSVVCEAIIPAKVVREVLKSSTEALVEVNINKNFIGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITIMEATGPTYEDLYISCTMPSIEIGTVGGGTNLAPQQACLQMLGVQGASTETPGKNACQLAQIVCSTVMAGELSLMAALAAGHLVKSHMVHNRSKINLQDLPGTCTKKAA
What is the function of this protein?
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.
Protein: DDX56_BOVIN
Sequence: MEDPESLGFEHMGLDHRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRALVLVPTKELARQAQSMIQQLAAYCARDIRVANVSAAEDSASQRAVLMEKPDVVVGTPSRILNHLQQDNLKLRDSMELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPACVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGPPVKGKHRGKGPKRDKASDPEAGVARGIDFHHVCAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQSQLGKIEELLSGDSGAPVLLPYQFHMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGNVPDYLVPPALRGLVHPHKKRKKPLASKKAKKAKTQNPLRSFKHRGEKCRPTAAPS
What is the function of this protein?
Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization.  Plays an essential role in maintaining nucleolar integrity in planarian stem cells (By similarity).  Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity).  Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3.  Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5.  May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits.  Has intrinsic ATPase activity (By similarity).
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX56, DEAD box protein 56.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: YO04_BPL2
Sequence: MQENAMEAANWALTIFFYGLSWFIAVGSIMILWPVWEYLKKKAHEQKLKGEEIIVAQAMTEQKLTIDFLREEAAVKELERLKAESLEIKERNAVEIDGIDYQGLTTIELKAKAKELGITGISRRSKNQLIEDIKQALIEQAVETENVVLNDDAHAHAVASV
What are the official names of this protein?
Uncharacterized 18.2 kDa protein, ORF4.
Protein: PRC2A_HUMAN
Sequence: MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPLKITKGKLGGPKETPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGRPPPQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHIWNRLHTATSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPREQPLPPGPIGTERSQRTDRGTEPGPIRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKELTASVTEAIPVSRDWELLPSAAASAEPQSKNLDSGHCVPEPSSSGQRLYPEVFYGSAGPSSSQISGGAMDSQLHPNSGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGLALKGQFLDFSTMQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPASLGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFSGLNSRLKATPSTYSGVFRTQRVDLYQQASPPDALRWIPKPWERTGPPPREGPSRRAEEPGSRGDKEPGLPPPR
What is the function of this protein?
May play a role in the regulation of pre-mRNA splicing.
What are the official names of this protein?
Protein PRRC2A, HLA-B-associated transcript 2, Large proline-rich protein BAT2, Proline-rich and coiled-coil-containing protein 2A, Protein G2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PRGR_GORGO
Sequence: MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPYPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLETLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQGVLSPLMSRSGGKAGDSSGTAAAHKVLPRGLSPSRQLLLPVSGSPHWSGAPVKPSPQPAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPSASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRAPPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGIPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
What is the function of this protein?
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Transcriptional activator of several progesteron-dependent promoters in a variety of cell types.  Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
What are the official names of this protein?
Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity).
Protein: YIDC_MALP2
Sequence: MKNSYINDNFIVSPLWTQAVDPQKEKKEKVVKILKIILKFTKLFIYAFLFLMGLWGCFQTMVDPTVKTSTTIGSGMEFGFPFGSTGDFRYDLTSGANNEYYAFTSTQWNISDYGPFFGLFVYPGAMLVLSIMYPLRDVWGGLDALLGIFVLLFIIRLITFLISIRSTMQSERMSEIQGKLAEINAKYKDVKKDMAMRQKKQLETQELYKKYNIKPFAMFEQMFVTMPIFLIVYRVVTILRPIKVINLFNIWALSASPLSEITSNLSNGGWVFIFFLLIIVPSQIISQKIPQILAKRRNANARALSQKGNDSAKKMRISQTVVMVVLVFVVVQSPASVGLYWFLSSLFTIAQSVIIHHYIVKRKTKGVSLEEKLRELGIK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL22_ACAM1
Sequence: MTTQLKDINGAYAKAKYIRMSPRKVRRVLDQIRGRSYREALIVLEFMPYRACEPVLKVLRSAVANAETNRGLDPVDLVVSHAYADQGPRLKRFRPRAQGRAYQIQKPTCHITIAVSAEAS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL13_CHLL2
Sequence: MSKTLSFKTYSAKPAEVERKWYVIDAEDQILGRMAAEIAKVLRGKHKPQFTPHIDTGDFIVVTNAEKVALSGKKIEYKTYFHHSNYPGGGKFDHVKDLLKKKPEKVIEHAVWGMLPHNNLGRQLFKKLKVYAGSEHPHTAQCPVELKVN
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: VF196_ASFM2
Sequence: MLFRYLVWLFRFIEVKNIASISLLVIGSNYLTTAIPNNTSTNISPTTSSNYSMTAIPNNTSTNISPTTSSNYSMTAIPNNTSTNISPTTSSNYSMTAIPNNISDKEDYTYFSTDKTASDGFTPITLYRAIRSTLNDTSTKTMTDHGLTRPYRPTTVIFHSDTSLPVKNATRDNIIKKTYRQVLSFFIRSNPLFPCFKNHEVFLNLANILNTILCIIVIKNV
What are the official names of this protein?
Late protein I196L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus I196L family.
Protein: LPXB_PERMH
Sequence: MKKAFISVGEISGDNYASQLVKALPDFMWVGITGPKMREAGVETVEKLENISVVGLMEALPKYFKIKETFKRSVEILDKGIDLLVVVDFPGFNLKLLKEAKKRGIKTVYFIAPQVWAWGKGRIPKIAQYTDLLIAIWPFEKEIYTDYISDSFRVEYVGHPILDIIKTEETEESFKEKIGIEKDKKIFGLLPGSRESEVKTLLPILLSSAEIIYRKREDLHFVIPSTPNMEENVKQIAGSKKVPLSVITVKDFRHPSYEVMKHSVFLNVASGTATLETAIFGNPFLLVYKVSPVTFFIGKMLVSIDYLGLPNIIAGREIIKELLQKECNPESIARWSLRYLEDPEVYERTKNDLEKVKKALGEKGAIKRSADLIKELSLS
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.