PharMolix/UniProtQA huggingface dataset:
Protein: DHH1_MAGO7
Sequence: MADVLADQLRSATLSDATNNEDWRRNLNIPARDNRQQTEDVTNTKGLEFENFGLKRDLLMGIFEAGFEKPSPIQEESIPVALTGRDILARAKNGTGKTAAFVVPALETINPKVSKIQCLILVPTRELAMQTSQVCKTLGKHLGINVMVTTGGTTLRDDILRLQDPVHIVVGTPGRILDLAGKNVADLSECPMFIMDEADKLLSIEFTPVIEQLLQFHPKDRQVMLFSATFPISVKEFSDKNMTNPYEINLMDELTLRGITQYYAFVEEKQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHAKMQQQARNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRYGHLGLAINLISWEDRFNLYNIERDLGTEIQPIPSTIDKSLYVYDNPETIPRPINIPAQPSSAGNAQSAAPNQGPPPQQQRPHQGQENWQNQNGRHNGSSQQQQPRGPHQNRGRGGGRGRGGFQGQGQGQRNYNNNYRGGRGGHNQGQHQQQMPNQQS
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1.  Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs.  May also have a role in translation and mRNA nuclear export (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DHH1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Protein: ARNE_AERHH
Sequence: MDILLLLLVCLLTCGGQMLQKQAVVSWQRRPCNHWQKLRSPWLIASVAALGCGMLLWIYLLQRLPLSMAYPMLSINLVLVLVGSRLFFHEQISYHNWLGVGAIIVGALLLGGLL
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE, L-Ara4N-phosphoundecaprenol flippase subunit ArnE, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE.
What is the protein family that this protein belongs to?
Belongs to the ArnE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y01A_BPT4
Sequence: MVYVYAIVYRDKDGFTAPVPLDEHRPAVFFEWKIADKVFTTLKEQYRLALGKGIPRLVETPRKFWFNKIEVKHVKPDVDTQRLYQRILDTGRIVSIPIAGNLR
What are the official names of this protein?
Uncharacterized 12.1 kDa protein in dda-modA intergenic region.
Protein: FOLB_STAAS
Sequence: MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLAEAGRTDNVIDTVHYGEVFEEVKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVRENK
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.  Can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin.
What are the official names of this protein?
Dihydroneopterin aldolase, DHNA, 7,8-dihydroneopterin 2'-epimerase, 7,8-dihydroneopterin aldolase, 7,8-dihydroneopterin epimerase, Dihydroneopterin epimerase.
What is the protein family that this protein belongs to?
Belongs to the DHNA family.
Protein: CATA3_CUCPE
Sequence: MDPYKYRPSSAYNTPFCTTNSGAPIWNNTAVMSVGERGPILLEDYQLIEKIATFTRERIPERVVHRRGASAKGFFEVTHDISNLTCADFLRAPGVQTPVIVRFSTVIHERGSPETLRDPRGFAVKFYTREGNFDLVGNNFPVFFVRDAMQFPDVIRAFKPNPKSHLQEPWRYLDFCSYHPESLLSFAWFYDDVGIPINYRHMEGFGVQAYSLINKSGKARLVKFHWKPTCGVKSMMEEEAIRIGGTNHSHATQDLYESIAAGNFPEWRLYIQTIDYEDQNKYDFEPLDTTITWPEDVVPLQPVGRLVLNKNIDNFFAENEMLAFSMSLVPGIHYSDDKMLQARSFAYADTQRHRLGPNYLQLPVNAPKCPHHNNHHEGFMNFMHRDEEVNYFPSRYDPCRHAEKFPMPPNVLTGKRERCVIPKENNNFKQAGDRYRSWAPDRQDRFVKRFVEALSDPRVTDEVRNIWISYWSQADRSLGQKIASRLNVRPNI
What is the function of this protein?
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
What are the official names of this protein?
Catalase isozyme 3.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: GUF1_MOUSE
Sequence: MWALVGRALAPWAAGARHAAASEPRAACRLFSAAELKEKPDMSRFPVEDIRNFSIIAHVDHGKSTLADRLLELTGTIDKTKKNKQVLDKLQVERERGITVKAQTASLFYSFGGKQYLLNLIDTPGHVDFSYEVSRSLSACQGVLLVVDANEGIQAQTVANFFLAFEAQLSVIPVINKIDLKNADPERVGKQIEKVFDIPSEECIKISAKLGTNVDSVLQAVIERIPPPKVHRENPLKALVFDSTFDQYRGVIANIALFDGVVSKGDKIVSAHTKKAYEVNEVGILNPNEQPTHKLYAGQVGFLIAGMKDVTEAQIGDTLYLHNHPVEPLPGFKSAKPMVFAGVYPIDQSEYNNLKSAIEKLTLNDSSVTVHRDSSLALGAGWRLGFLGLLHMEVFNQRLEQEYNASVILTTPTVPYKAVLSSAKLIKEYKEKEITIINPAQFPEKSQVTEYLEPVVLGTVITPTEYTGKIMALCQARRAIQKNMTFIDENRVMLKYLFPLNEIVVDFYDSLKSLSSGYASFDYEDAGYQTAELVKMDILLNGNMVEELVTVVHREKAYTVGKSICERLKESLPRQLYEIAIQAAVGSKVIARETVKAYRKNVLAKCYGGDITRKMKLLKRQSEGKKKLRKIGNIEIPKDAFIKVLKTQPNK
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor Guf1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase Guf1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: SEQA_PROMH
Sequence: MKKIEIDDELYRYIASETRHIGESASDILRRLLKLDAKQPVQPVVVTESVQAPVVKQDADLKPVAPAKNPVREMRELLLSDSYAEKTKSVDRFLQILSTLYSLDSATFTQSAETVHGRTRIYFAGDEKTLLDSGRHTKPRHIPGTPFWVITNSNTERKRTMVQSIMQDMQFPANEIDKVCGTI
What is the function of this protein?
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle.  Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins.  Repression is relieved when the region becomes fully methylated.
What are the official names of this protein?
Negative modulator of initiation of replication.
What is the protein family that this protein belongs to?
Belongs to the SeqA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYR1_MICDP
Sequence: MPFGPASRLGVSLFDETPPVEWVPGRSQEEAETIIRAIYRQVLGNAYVMESERLAVPESQFKRGELSVREFVRAVAKSELYRSRFFTSCARYRAIELNFRHLLGRPPLDLEEMRSHSTILDTQGFEAEIDSYIDGDEYQSTFGENIVPYIRGYKTEALQSMVQFTHTFQLVRGASSSSLKGDLSGKAPKLNALVIQSTPTAVISPASAGATFSTPPTGARTRLGVDASAGGKVYRIEVTGYRAKTFNNISKFRRSNQVFLVPYEKLSQEYQRIHQQGGVIASITPV
What is the function of this protein?
Rod linker protein, associated with phycoerythrocyanin.  Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer.
What are the official names of this protein?
Phycobilisome 31.8 kDa linker polypeptide, phycoerythrin-associated, rod.
What is the protein family that this protein belongs to?
Belongs to the phycobilisome linker protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with phycoerythrin.
Protein: RAB21_DICDI
Sequence: MTDTEKSFKVVLLGEGCVGKTSIVFRYIDNIFNDKHLMTQHAGFFQKHINIGGKRICLTIWDTAGQERFHALGPIYYRGSQGALVVYDITDNDSFIKAKNWIKELKTMLGNDISLCIIGNKCDLEKTRVIPLADAEAYAKSVGAIHYSTSAKLNKGIEELFLDLTRRMILNSSGVVIHSNTNTTGQTTNRSERIPIVPDSDSGNKQPGCCSN
What is the function of this protein?
Involved in the regulation of phagocytosis.
What are the official names of this protein?
Ras-related protein Rab-21, Ras-related protein RabB.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: HBB_MARMA
Sequence: VHLSDGEKNAISTAWGKVNAADIGAEALGRLLVVYPWTQRFFDSFGDLSSASAVMGNAKVKAHGKKVIDSFSNGLKHLDNLKGTFASLSELHCDKLHVDPENFKLLGNMIVIVMAHHLGKDFTPEAQAAFQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: UGPA_YERPN
Sequence: MSPSRPGFSCSWLPYLLVLPQLAITAIFFLWPAGEALWYSVQTLDPFGLSSEFVGLSNFIQLFQDEYYLASFYTTLIFSALVAGIGLIVSLFLAAMVNYVLRGSRLYQTLLILPYAVAPAVAAVLWIFLFDPGLGLITHALAKLGYSWNHAQNSGQAMFLVVLASVWKQISYNFLFFLAALQSIPKSLVEAAAIDGAGPVRRFFNLVLPLISPVSFFLLVVNLVYAFFDTFPVIDAATGGGPVQATTTLIYKIYREGFAGLDLSSSAAQSVILMLLVIGLTVIQFRFVERKVRYQ
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpA.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL11_SALSV
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSIEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKISRAQLQEIAQTKAADMTGADIEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: 33K_ADES1
Sequence: MASEKSYKTVPVTGKNLAMIYHHMGNKTQSLEEAYKQLEKELGETQAPPPSPQSSLDGEPLSEGELEEISEEEEEEGEAPPPIPAKKRQRKNPSKAPAAKAPRNYGTPSYMLHVDLKHDIAGVLEEIRRASLKKPAHTPSIRNRTYPSITKRYLYERDSKKLQQYLDDSKKLLAKYSEGV
What are the official names of this protein?
Putative protein 33K.
Protein: TCMI_STRGA
Sequence: MAYRALMVLRMDPADAEHVAAAFAEHDTTELPLEIGVRRRVLFRFHDLYMHLIEADDDIMERLYQARSHPLFQEVNERVGQYLTPYAQDWEELKDSKAEVFYSWTAPDS
What is the function of this protein?
Catalyzing the conversion of tetracenomycin F2 to tetracenomycin F1.
What are the official names of this protein?
Tetracenomycin F2 cyclase, Tetracenomycin polyketide synthesis protein TcmI.
Protein: GSTF2_ARATH
Sequence: MAGIKVFGHPASIATRRVLIALHEKNLDFELVHVELKDGEHKKEPFLSRNPFGQVPAFEDGDLKLFESRAITQYIAHRYENQGTNLLQTDSKNISQYAIMAIGMQVEDHQFDPVASKLAFEQIFKSIYGLTTDEAVVAEEEAKLAKVLDVYEARLKEFKYLAGETFTLTDLHHIPAIQYLLGTPTKKLFTERPRVNEWVAEITKRPASEKVQ
What is the function of this protein?
Binds auxin, endogenous flavonoids and the phytoalexin camalexin and may be involved in regulating the binding and transport of small bioactive natural products and defense-related compounds during plant stress.  Binds a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde.  In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC).  Acts as glutathione peroxidase on cumene hydroperoxide, linoleic acid-13-hydroperoxide and trans-stilbene oxide, but not trans-cinnamic acid or IAA-CoA.
What are the official names of this protein?
Glutathione S-transferase F2, AtGSTF2, 24 kDa auxin-binding protein, AtPM24, GST class-phi member 2.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Phi family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Note=Plasma membrane vesicles.
Protein: LEXA_RHOPA
Sequence: MLTRKQFELLKFINERLKEAGVPPSFDEMKDALDLRSKSGIHRLITALEERGFIRRLPNRARAIEVIKLPDTGGMPGNSRRGFTPSVIEGNLGKVRPPSPTPAEDDHDRGSVAVPVMGRIAAGTPIEALQSRSHTISVPADMLGSGEHYALEVRGDSMVEAGILDGDMALIQKNDVADTGDIVVALIDEEEATLKRFRRRGASIALEPANAAYEVRILPPNRVRIQGKLIGLYRKY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: Y165_BACC2
Sequence: MIKPLIEFCVGNLASGSQAALEKLEKDPNLDVMEYGCLGYCGICFEGPFALVNGEVVQGATVEELVNNVYDYLDENPMF
What are the official names of this protein?
UPF0349 protein BCG9842_B0165.
What is the protein family that this protein belongs to?
Belongs to the UPF0349 family.
Protein: RSMC_SALTI
Sequence: MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARFECAASRAYTQQFHHWQALSRQMGDNVRFSLVAQASDVADCDTLIYYWPKNKPEAQFQLMNILSLMPVGSDVFVVGENRSGVRSAEPMLADYAPLNKVDSARRCGLYHGRLEKQPQFSLESWWAEYNIDGLTIKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSAALASHSPKVRLTLCDVSAPAVEASRATLAANGLEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPKILDETFGFHEVIAQTGRFKVYRIVMTRQAKK
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF1_HUMAN
Sequence: MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLVEIGLAKDDQLKVHGF
What is the function of this protein?
Necessary for scanning and involved in initiation site selection.  Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.
What are the official names of this protein?
Eukaryotic translation initiation factor 1, eIF1, A121, Protein translation factor SUI1 homolog, Sui1iso1.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: 032R_IIV6
Sequence: MGVYKFCYNKKKEVGQVAVLQKERLIFYIVTKEKSYLKPTLANFSNAIDSLYNECLLRKCCKLAIPKIGCCLDRLYWKTVKNIIIDKLCKKGIEVVVYYI
What are the official names of this protein?
Uncharacterized protein 032R.
Protein: LMO42_XENTR
Sequence: MVNPGSSSQPPPVTASTLSWKRCAGCGGKIADRFLLYAMDSYWHSRCLKCSCCQAQLGEIGTSCYTKSGMILCRNDYIRLFGNSGACSACGQSIPASELVMRAQGNVYHLKCFTCSTCRNRLVPGDRFHYINGSLFCEHDRPTALINGHLNSLQSNPLLPDQKVC
What is the function of this protein?
Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation.  Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors.  At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity).
What are the official names of this protein?
LIM domain transcription factor LMO4.2, LIM domain only protein 4.2, LMO-4.2.
Protein: ACKA_STAES
Sequence: MSKLILAVNAGSSSLKFQLIKMPEEKLVTKGVIERIGLSDSIFTIHVNGEKLTDIRDIHNHEEAVNIMLDSFKEHEMIKDITDIQGTGHRVVHGGETFPKSVVVTDEVESQIEELSELAPLHNPANLMGIRAFRKLLPEIPHVAVFDTSFHQTMPEQAYLYSLPYHYYEDYGIRKYGFHGTSHKYVSRRAAQIVGRPIEDLRIISCHIGNGASIAAIDGGESIDTSMGFTPLAGVTMGTRSGNLDPALIPFIMEKTGKTADEVLEILNKESGLLGLTGTSSDLRDLTEEAKHGRQRSRVALDLFASKIHKYIGSYAARMHGVDVIVFTAGIGENSHIIRGKVLEGLEFMGVYWDPKKNESLHGEEGYINYPHSPVKVLVVPTDEEVMISRDVIKYGKLNDNTPKKEEFDTNESIEVN
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN168_HUMAN
Sequence: MALPKDAIPSLSECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLCCPFCRRRVSSWTRYHTRRNSLVNVELWTIIQKHYPRECKLRASGQESEEVADDYQPVRLLSKPGELRREYEEEISKVAAERRASEEEENKASEEYIQRLLAEEEEEEKRQAEKRRRAMEEQLKSDEELARKLSIDINNFCEGSISASPLNSRKSDPVTPKSEKKSKNKQRNTGDIQKYLTPKSQFGSASHSEAVQEVRKDSVSKDIDSSDRKSPTGQDTEIEDMPTLSPQISLGVGEQGADSSIESPMPWLCACGAEWYHEGNVKTRPSNHGKELCVLSHERPKTRVPYSKETAVMPCGRTESGCAPTSGVTQTNGNNTGETENEESCLLISKEISKRKNQESSFEAVKDPCFSAKRRKVSPESSPDQEETEINFTQKLIDLEHLLFERHKQEEQDRLLALQLQKEVDKEQMVPNRQKGSPDEYHLRATSSPPDKVLNGQRKNPKDGNFKRQTHTKHPTPERGSRDKNRQVSLKMQLKQSVNRRKMPNSTRDHCKVSKSAHSLQPSISQKSVFQMFQRCTK
What is the function of this protein?
E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage.  Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination.  Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates.  This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1.  Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair.  H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates.  Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair.  Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites.  Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region.  Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF168, hRNF168, RING finger protein 168, RING-type E3 ubiquitin transferase RNF168.
What is the protein family that this protein belongs to?
Belongs to the RNF168 family.
Protein: Y3692_BACHK
Sequence: MASETVSNHQEKALALLQADAEKILRLIKVQMDHLTMPQCPLYEEVLDTQMFGLSREVDFAVRLGLIAEEQGKAMLGELERELSALHEAFTNKQQ
What are the official names of this protein?
UPF0358 protein BT9727_3692.
What is the protein family that this protein belongs to?
Belongs to the UPF0358 family.
Protein: EOS1_YEAST
Sequence: MTWILSTGMGPHEDKYAKHERATFKKTYSSMKTLSLNHLTAKQHMLMALCRDISLLPPLTYIFTSLRKAWRVSMRTSITLYEPQSLRDAFTYFWQKLNSAYDNNSSFEGASQKAVNGDGKDSLLLSALTTARASEYLLCSLWCLVSLYLSYAILDSLMVRWIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQSYLTSDLRYIRNQEGEVQEDTNVPEETEDYEDGEDDADEDSHVVVADESTVDVPSNDSLSDNSDGGLFPVNRPSVSHSQSPKRPKKYPKKAFNFTTKRTIDLYKITVLCVVPVGLASFITMLGLLRNLFIQRLDVEQLERILHEMHPPA
What is the function of this protein?
Involved in oxidative stress resistance and N-glycosylation.
What are the official names of this protein?
N-glycosylation protein EOS1, ER-localized and oxidants sensitive protein 1.
What is the protein family that this protein belongs to?
Belongs to the EOS1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: AHPF_ACICA
Sequence: MLDQNIXTQLXAYLER
What is the function of this protein?
Serves to protect the cell against DNA damage by alkyl hydroperoxides.  It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein (By similarity).
What are the official names of this protein?
Alkyl hydroperoxide reductase subunit F.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
Protein: OL867_RAT
Sequence: MILNCNPFSGLFLSMYLVTVLGNLLIILAVSSNSHLHNLMYFFLSNLSFVDICFISTTIPKMLVNIHSQTKDISYIECLSQVYFLTTFGGMDNFLLTLMACDRYVAICHPLNYTVIMNLQLCALLILMFWLIMFCVSLIHVLLMNELNFSRGTEIPHFFCELAQVLKVANSDTHINNVFMYVVTSLLGLIPMTGILMSYSQIASSLLKMSSSVSKYKAFSTCGSHLCVVSLFYGSATIVYFCSSVLHSTHKKMIASLMYTVISPMLNPFIYSLRNKDVKGALGKLFIRVASCPLWSKDFRPKFILKPERQSL
What is the function of this protein?
Possible olfactory or taste receptor.
What are the official names of this protein?
Olfactory receptor 867, Gustatory receptor GUST27, Olfactory receptor 1172.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MIAB_CLONN
Sequence: MEDLVLDNNTKNIYNKRFFISTWGCQMNEEDSEKISGLLKGIGYTRTDIRDEADVVIFNTCCVRENAEQKVYGHLGELKALKRKNPNLILIVTGCMMQQKGMPEKVMEKFPHVDIIAGTYNSYKLPEYIERVKTEGNSIIEIWDKEKGIVEGLPVDRKSDIKAFVTIMYGCNNFCSYCIVPYVRGRERSRDPQNIIDEIKDLVSKGYKEITLLGQNVNSYGKGLEPEINFATLLRMVNKIDGLERIRFMTSHPKDVSDELIKAMAECEKVCEQGHFALQSGSTEILQKMNRKYTREDYLTLVKKLRKAMPNVGISTDIIIGYPGETEKDFEDTLSIVKEIEFDSAFTFIYSKREGTPAAKLEDQVPEDVKHTRFNKLVEAVNEIMARKNKEFEGKTVEVLVEGPSKNDDTKLMGRTRSGKLVNFNGCLDQVGKLVNIKITKANSFSLTGEII
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERC_RICB8
Sequence: MLDTQIQELIIKWQKYLSLQKNYSNHTLISYNNDLKHFLEFMNYYNSDIVTMDYIKAADIRLMRSWLAKRKCDNFVTSSIARGLSAIKNFYKFLEKTAELHNHVVFSIKSPKKSKLLPKALSEEEVNISLDHIEEYGNSQWIEIRNKALLVLIYASGLRISEALSITKLHLQNLEFIKIMGKGSKERVIPWLAIARNLITEYLEKLPYELKDDEPIFRGKQGKKLQPPVFNRELIKLKRFYGLPEHLSAHSFRHSFASHLLENGADLRSIQELLGHKSLSTTQSYTKTSIKHLETAYVTAHPIKK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_PSYCK
Sequence: MIQVESMLEVADNSGARRVQCIKVLGGSHRRYASVGDIIKVTVKEAIPRGRVKKGDVMNAVVVRTKKGVRRPDGSVLRFDDNAAVLLNQNKAPIATRIFGPVTRELRGDQFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.