PharMolix/UniProtQA huggingface dataset:
Protein: ATF21_SCHPO
Sequence: MDFANVYLGLDTLGNEGYGASVSNGTHHDFHFNFNTFRDGGNHEVGEKRAESSDIGVYECRGPVQGPKDQTSFPSNSHNNYASIVGDASIGHYLKGPERTSEVSLPQTVNLSEISNNNDKGQPTNTPPVRSTIVAPSLYSEGSTLNHYNNGSHQVLHPQFQNGTNAPYVVQSNLMQNNVNLTGAEQEKGLDLYKNSATANNDEIFYNLESLRREGYLNSNKKQSQSPNGDYNSSDESCSNKTVASSQRRGTPGSNNVHTASNNETPDMKRRRFLERNRIAASKCRQKKKLWTQNLEKTAHIACEQSKALRILVSQLREEVICLKNQLLAHQDCNCEGIRQYLSSEAQGIMSFQKH
What are the official names of this protein?
Transcription factor atf21.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: THII_BACCR
Sequence: MLKYEYILVRYGEMTTKGKNRSKFVSTLKDNVKFKLKKFPNIKIDATHDRMYIQLNGEDHEAVSERLKDVFGIHKFNLAMKVPSELEDIKEGALAAFLQVKGDVKTFKITVHRSYKRFPMRTMELLPEIGGHILENTEDITVDVHNPDVNVRVEIRSGYSYIMCDERMGAGGLPVGVGGKVMVLLSGGIDSPVAAYLTMKRGVSVEAVHFHSPPFTSERAKQKVIDLAQELTKYCKRVTLHLVPFTEVQKTINKEIPSSYSMTVMRRMMMRITERIAEERNALAITTGESLGQVASQTLDSMHTINEVTNYPVIRPLITMDKLEIIKIAEEIGTYDISIRPYEDCCTVFTPASPATKPKREKANRFEAKYDFTPLIDEAVANKETMVLQTVEVVAEEEKFEELF
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_BUCA5
Sequence: MFDSNHEQELSKRRTFAIISHPDAGKTTITEKMLFFGKVIRVPGTIKGRGSGKYAKSDWMNIEKERGISITTSVMQFTYKNILMNLLDTPGHQDFSEDTYRILTAVDCCLVVIDAAKGIEERTRKLMDVARIHNTPIITFINKLDRDSRDPIEILDEIEKELKLHCIPISWPISCGKNFQGVYHIYDKIIHLYKSKFRKNFLTLDSFLDGSLNEYLGADLSIHIRQELELIMNVYSKFNKEKFLKGITTPIFFGSALGNFGIDHLLDSLIKWAPSPLYRQSNKRIIKPQERKFTGFIFKIQANMDLKHRDRIAFMRIVSGQYTKGMKLTHVRIKKNIIISDAFSFLAGERISINKAYPGDVIGLHNHGTIKIGDTFTQGEEIKFIGIPSFAPEIFRLIYLKNPLKQKQLKKGLVQLSEEGTVQVFRPILNNDLILGAIGILQFDVVIERLRIEYNIDAVYKKVNIVLARWINCGNHHSLYNLKKSYSSYLAYDISNSLIYLAPSSANLNIVMSQNSDISFNATREQ
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSP8_CROAD
Sequence: MVLIRVLANLLILQLSYAQKSSELVIGGDECNINEHRSLVAIFNSTKFFCSGTLINQEWVVTAAHCDSTNFKMKLGVHSKKVPNENEQTRNPKEKFFCPNKKKDDVLDKDIMLIKLDSPVSNSEHIAPLSLPSSPPSVGSVCHIMGWGSITPIEKTLPDVPYCANINLLDDAVCRPPYPELPATSRTLCAGILEGGKDTCRGDSGGPLICNGQFQGIVFYGAHPCGQALKPGVYTKVFDYNDWIQSIIAGNTAATCPP
What is the function of this protein?
Snake venom serine protease that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine proteinase 8, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GAL1_VIBVY
Sequence: MSELIQNVKTSFEQVLGYAPSHIIQAPGRVNLIGEHTDYNDGFVLPCAINYQTVVAAAKREDNLVRVVSVDYGNAVDEFDITQAITFQQDKMWANYIRGVVKCLLARGYAFTGADISVSGNVPQGAGLSSSAALEVVIGQTFKVLFNLEISQAEIALNGQQAENEFVGCNCGIMDQMISAEGRENHAMLLDCRSLETESVSMPEEMAVVIINSNKKRGLVDSEYNTRRQQCEEAARIFGVKALRDVTIEQFNEKVAELDEMVAKRARHVITENDRTVEAAQALRAHDMKRMGELMAESHASMRDDFEITVKEIDTLVEIVKEVIGDQGGVRMTGGGFGGCIVALVPPALVDDVKATVAAKYQAATGLKESIYVCQAKDGAGLVEML
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXA_KRYAS
Sequence: MKFGNFLLTYQPPQLDQKEVIKRLVNLGQASESCGFDTAWLLEHHFTEFGLLGNPYVAAANLLGATKKLHVGTAAVVLPTAHPVRQLEDVNLLDQMSKGRFKFGICRGLYDKDFRVFGTDMSNSRELMNSWYDIMTKGMIEGHVSSDNEHIKFPKVKVSPNSYTQRGAPVYVVAESASTTEWAAERGLPIILSWIINNNEKKSQLDLYNEIALEHGHDVSNIDHCMSYITSVDHNSNKAKDICRDFLAHWYDSYLNATSIFDDSNQTKGYDFNKGQWRNFVLKGHKDTNRRIDYSYEINPVGTPQECIEIIQSDIDATGIHNICCGFEANGSETEIIASMKLFQSDVMPYLKEKSNC
What is the function of this protein?
Light-emitting reaction in luminous bacteria.
What are the official names of this protein?
Alkanal monooxygenase alpha chain, Bacterial luciferase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the bacterial luciferase oxidoreductase family.
Protein: YTCA_ECOUT
Sequence: MPTVLSRMAMQLKKTAWIIPVFMVSGCSLSPAIPVIGAYYPGWFFCAIASLILTLITRRIIQRTNINLAFVGIIYTALFALYAMLFWLAFF
What are the official names of this protein?
Uncharacterized protein YtcA.
What is the protein family that this protein belongs to?
Belongs to the YtcA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Membrane; Multi-pass membrane protein.
Protein: PAP1_RABPU
Sequence: MNRNPDQNTLPNITLKIIETYLGRVPSVNEYHMLKLQARNIQKITVFNKDIFVSLVKKNKKRFFSDVDTSASEIKDRILSYFSKQTQTYNIGKLFTIIELQSVLVTTYTDILGVLTIKAPNVISSKISYNVTSMEELARDMLNSMNVAVIDKAKVMGRHNVSSLVKNVNKLMEEYLRRHNKSCICYGSYSLYLINPNIRYGDIDILQTNSRTFLIDLAFLIKFITGNNIILSKIPYLRNYMVIKDENDNHIIDSFNIRQDTMNVVPKIFIDNIYIVDPTFQLLNMIKMFSQIDRLEDLSKDPEKFNARMATMLEYVRYTHGIVFDGKRNNMPMKCIIDENNRIVTVTTKDYFSFKKCLVYLDENVLSSDILDLNADTSCDFESVTNSVYLIHDNIMYTYFSNTILLSDKGKVHEISARGLCAHILLYQMLTSGEYKQCLSDLLNSMMNRDKIPIYSHTERDKKPGRHGFINIEKDIIVF
What is the function of this protein?
Polymerase that creates the 3'-poly(A) tail of mRNA's.
What are the official names of this protein?
Poly(A) polymerase catalytic subunit, Poly(A) polymerase large subunit, PAP-L.
What is the protein family that this protein belongs to?
Belongs to the poxviridae poly(A) polymerase catalytic subunit family.
Protein: GFI1B_MOUSE
Sequence: MPRSFLVKSKKAHTYHQPRAQGDELVWPPAVIPVAKEHSQSASPLLSTPLPSQTLDWNTIKQEREMLLNQSLPKMASAPEGPLVTPQPQDGESPLSESPPFYKPSFSWDTLASSYSHSYTQTPSTMQSAFLERSVRLYGSPLVPSTESPLDFRLRYSPGMDTYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDVCGKTFGHAVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK
What is the function of this protein?
Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages.  Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.  Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways.  Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate.  Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells.  Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells.  Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction.  Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression.  Alters histone methylation by recruiting histone methyltransferase to target genes promoters.  Plays a role in heterochromatin formation.
What are the official names of this protein?
Zinc finger protein Gfi-1b, Growth factor independent protein 1B.
Protein: MRAY_BIFLD
Sequence: MIALIIGMLVSLIVTLVGTPLLIRLVHKLHYGQYIRQDGPQSHLVKRGTPTLGGVVINFAILLGWASSALYRYLRSGDVPSWSAALVLFAMLSMGLLGFIDDFAKVRKKQNEGLSVGGKFIGQFIFATIYAVLALLIPTKSGFPSAQAGISFIEQPFFNFDFAGRAVAIILFVIWVNFLMTAWTNAVNLTDGLDGLAAGSSMIAFTGFGIIAFWESYHIKGGSHGGYSYAVSDPLDLTVIAVCAAVACFGFLWYNSNPASIFMGDTGSLALGGLFAALSIATHTEFLAVVLGGLYVMEAMSDVIQVGYFKMTHKRVFKMAPIHHHFELEGWTETKVVVRFWMIELIFVLLALTIFYGDWVTRSGLLFS
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FTSQ_BURPS
Sequence: MWNNVRQLNLAASALYALLLLVLAAAGCYWLIQRPAFALREIRIDGDTEHINAPTVRAGVVGRLKGNFFTVDLDLARVAFEQMPWVRHASVRRVWPNALAVTLEEYKPLGTWGNDQLVSVDGELFTANQGELDAELPSFDGPEGSAKEVVARYRDFAKWFAPIHATPEEVTLSPRYAWTVKLSNGMQVELGRERNSDTLPDRIQRLVAAWPSVTQRWGGDIEYADLRYPNGFAIRAAGMRFLTDTDKGKK
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.  May control correct divisome assembly.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: YB3_XENLA
Sequence: MSSEVETQEQQPDALEGKAGQEPAATVGEKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGPVPVQGSKYAADRNNYRRYPRRRGPPRNYQQNYQNSESGEKAEGNESAPEGEGTNQQRPCPRRRYPPPFYSRRPYGRRPQYSNVPVQGESAEGAESQGAGEQGRPVRQNMYRGFRPQFRRGPPRQRQPREDGNEEDKENQGDETQSHACHLMRRYRRNFNYRRRRPENPKPQDGKETKAAETSAENTSAPEAEQGGAE
What is the function of this protein?
Binds the B box promoter element of genes transcribed by RNA polymerase III and is probably involved in the regulation of class III genes.
What are the official names of this protein?
B box-binding protein, Protein YB3.
What are the subcellular locations of this protein?
Nucleus.
Protein: OMT3_HUMLU
Sequence: MEKLKSFRHLNNNIDLILNEENSTEILGAQAHIWNQIFNFINSMSLKCAIQLGIPDIINNHGKPMTISQLTLALPINRKKSPCVYRLMRILIHSGFFALQKAEVGEEGGGEEEGYVITDASKLLLKDNPMSVTPFLLAMLDPVMTKPWDFLSNWFQNGDPTPFDTANGMAFWDYGSHEPKLARFFNDAMASDARLVTSVVIEKCKGVFEGVESLVDVGGGTGTVASSIAAAFPHIQCTVFDLPHVVADLQGGNNLNFVGGDMFVDVPATEVVLLKWILHDWNDEESVKILKKCKEAISKSNKKGGKVIIIDMKVENEKDEDDESYETQLFFDMLMMALVTGRERNEKEWAKLFKDAGFSNYKITPILGLRSLIEVYP
What are the official names of this protein?
Probable O-methyltransferase 3, HlOMT3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: HSP21_IPONI
Sequence: MDLRLMGFDHPLFHHIMDYAGDDKSSNSSAPSRTFMLDAKAMAATPADVKEYPNSYVFIIDMPGLKSGDIKVQVDGDNVLSISGERKREAEEKEGAKYVRMERRVGKLMRKFVLPENANKEKITAVCQDGVLTVTVENVPPPEPKKPRTIEVKIG
What are the official names of this protein?
17.2 kDa class II heat shock protein.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_ECOLU
Sequence: MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV, Heat shock protein HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP7_BTV1A
Sequence: MDTIAARALTVMRACATLQEARIVLEANVMEILGIAINRYNGLTLRGVTMRPTSLAQRNEMFFMCLDMMLSAAGINVGPISPDYTQHMATIGVLATPEIPFTTEAANEIARVTGETSTWGPARQPYGFFLETEETYQPGRWFMRAAQAVTAVVCGPDMIQVSLNAGARGDVQQIFQGRNDPMMIYLVWRRIENFAMAQGNSQQTLAGVTVSVGGVDMRAGRIIAWDGQAALQIHNPTQQNAMVQIQVVFYISMDKTLNQYPALTAEIFNVYSFRDHTWHGLRTAILNRTTLPNMLPPIFPPNDRDSILTLLLLSTLADVYTVLRPEFAIHGVNPMSGPLTRATARAAYV
What is the function of this protein?
The VP7 protein is one of the five proteins (with VP1, VP3, VP4, and VP6) which form the inner capsid of the virus.
What are the official names of this protein?
Core protein VP7.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP7 family.
What are the subcellular locations of this protein?
Virion.
Protein: RL17_HELPY
Sequence: MRHKHGYRKLGRTSSHRKALLKNLAIALIEHNKIETGIYKAKELRSYIEKLTTAARVGDFNAHRHVFAYLQNKEATHKLVTEIAPKYAQRNGGYTRIQRTTFRRGDASTLATIEFV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: PROA_ROSS1
Sequence: MTNIEEIGARARAAGRRMALMPTERKNAALEAIATALIDEANAAEVLAANAIDVAAGRDAGLSPALIDRMTLTPQRLAAIAADTRAVARLPDPVGERFDATVLENGLRVHKRRVPLGVVGVIYEARPNVTVDVAALCLKSGNAAILRGGKEITRSCAALTRLIQNAITQTGLPADAIQVIDDPDRALVEQLLRLDRYVDVIIPRGGAGLHRFCREKATIPVITGGIGVCHIYVDQAADLEMVVPIVHNAKVQRPSVCNALDTLLVHRAVAADVLPAVARDLLASNVELRADEAALAILRDAGFDTPQIVPAQESDFGVEFMALILSIRVVSGLDEALDHIARFGDHSDAIITRDAATAEVFVQAVDSSAVFVNASTRFNDGGQLGLGAEIAISTQKLHARGPMALRELTSYKWVVEGDGHVRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU1M_EMBAL
Sequence: MFLVNLLLMIIPILLAVAFLTLLERKTLGYMQLRKGPNIVGPHGLLQPIADAIKLFTKEPLRPLTSSTSMFIMAPILALSLALTMWTPLPMPYPLINMNLGVLFILAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFSLPNLSTTQENLWLIIPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAGGSFALFFLAEYANIIMMNAITTTLFLGLYQNPSLPEFYTTSFMIKTLLMTITFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSIPILTASIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: METK_ECOLU
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXVE_DABPA
Sequence: QVRPFLDVYQRSACQARETLVSILQEYPDEISDIFRPSCVAVLRCSGCCTDESLKCTPVGKHTVDMQIMRVNPRTQSSKMEVMKFTEHTACECRPRRKQGEPDGPKEKPR
What is the function of this protein?
Snake venom VEGFs that may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension.  This protein potently stimulates dermal human microvascular endothelial cell (dHMVEC) proliferation in a VEGFR-2 dependent manner (PubMed:17852405).  This stimulatory effect is correlated with activation of the MAPK Erk1/2 signaling pathway (PubMed:17852405).  It also appears to be a chemoattractant for migration of these cells and stimulates their radial migration in a collagen gel (PubMed:17852405).  In vivo, it induces angiogenesis in a Japanese quail assay (PubMed:17852405).  This pro-angiogenic effect may also be related to its interaction with VEGFR-2 (PubMed:17852405).  In addition, it may induce an increase in capillary permeability after intradermal injection, as well as a drastic hypotensive effect after intravenous injection (By similarity).  The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase (By similarity).
What are the official names of this protein?
Snake venom vascular endothelial growth factor toxin, svVEGF, VEGF-F, VpVEGF.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family. Snake venom VEGF subfamily.
Protein: ENGB_MARSD
Sequence: MDNTLTLIKTVYEINQLEEIAAPQIILAGRSNVGKSSLINCLASRKKLAKISSTPGKTRSLNYYEVSPHGYYIVDLPGYGYARCSKTERAKWAKLIDKYLLDNAYVAAAAVLLDSRHNPQQNDLDLISYFKHCNIPIIPIMTKSDKTKQKDRSKVQKKWEDILKVKPICVSSKTGMNRTRLWNLLDVTAIPELAEIEEETE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: CD5R1_BOVIN
Sequence: MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGVSSSVKKAPHPAVSSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
What is the function of this protein?
p35 is a neuron specific activator of CDK5.  The complex p35/CDK5 is required for neurite outgrowth and cortical lamination.  Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling.  Activator of TPKII.  The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.
What are the official names of this protein?
Cyclin-dependent kinase 5 activator 1, CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the cyclin-dependent kinase 5 activator family.
What are the subcellular locations of this protein?
[Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, neuron projection. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus. Cytoplasm, perinuclear region. Perikaryon. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.
Protein: PLPL7_RAT
Sequence: MQKEEDVCPEAGYCLGTALSSWGLHFMEEHSQSTMLMGIGIGVLLTLAFVGLAAFFVYRKVSRFRRAEPIPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTAAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVASTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSPRLSEFNSSDQRSVAVSGPLLKRSCSVPLPPIHGEIDELRQAQGSGSNTSAFQESQEGATSDLGMAYNRARILPHSEEQLGSSLASKSKKSVVAETSAVFHYSEKPRDEPGPSGRTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTIVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVRRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVEMLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSGTGHQLGFNTASSKWDLGNPPGNLSTVAAMPVSEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADSTLTPWTQRCIRQADCILIVGLGDQEPALGELEQMLESTAVRAQKQLILLHKEEGPAPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRIFQRPPDRHSDFSRLARILTGNAIALVLGGGGARGCAQVGILRALAECGIPVDIIGGTSIGAFMGALFAEERSYSQIRIRAKQWAEDMTSMVKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGALWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGPAGFDIWVRSGVLEKMLQDQQGTSKRMDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSECEPSMSQGPHSLTSPKQSQDSFPWLPNQDDQGPRLYRPS
What is the function of this protein?
Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine.  Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0).
What are the official names of this protein?
Patatin-like phospholipase domain-containing protein 7, Liver NTE-related protein 1, NTE-related esterase.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Lipid droplet.
Protein: F16PC_CLOBB
Sequence: MEVKMNKNEQEDSKKLKYFRLLAKQYPNIALASTEIINLEAILNLPKGTEHFLSDIHGEYEPFVHVLRNGSGVVKRKIEDLFCKSLLESDIKSLATLIYYPEQKLDIVLKEERNIDDWYKITLNRLIEICRFCSSKYTRSKVRKALPADFAYIIEELLHEQFNGIDKEEYYDRIITTIIDIGRAKEFIIALSKLIQRMIIDRLHIIGDIYDRGPRPDIIIDTLMEYHSVDIQWGNHDMLWMGAAAGVRTCVANVLRISTRYANLDLVEEIYGINLLPLATFALKYYRDDPCESFIPKVKEDDPAASQEVDLVSKMHKAITILQFKLEKEIIDRRPEFELEGRLLLDKIDYEKGTIILNGIEYKLNDNNFPTIDPKDPYKLTDEESVLIDKLVYSFVNSDKLQKHVRFLFSKGNMYLKFNSNLLFHGCIPLDDEGNLKSMCIQGEEYESKRLLEKFDSLSREGYFEKVGSEEKTYGMDIMWYLWTGPVSPLFGKKQMATFERYFIDDEIAHIEQKTGYYKLRDREEMCDMILREFGLDPSESRIINGHVPVKKKNGESPIKANGKMIVIDGGFSKAYQKQTGIAGYTLIYNSYGLQLVSHEHFSSTEESIMKEKDILSTTLVVEQKLKRKTVEDTDIGKDLQVQIKDLKELLLIYRKGIIKEIR
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 3, FBPase class 3, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 3 family.