PharMolix/UniProtQA huggingface dataset:
Protein: SGMR1_MOUSE
Sequence: MPWAAGRRWAWITLILTIIAVLIQAAWLWLGTQNFVFSREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCILHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWKEGTTKSEVFYPGETVVHGPGEATALEWGPNTWMVEYGRGVIPSTLFFALADTFFSTQDYLTLFYTLRAYARGLRLELTTYLFGQDS
What is the function of this protein?
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane (PubMed:12730355).  Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling.  Also regulates ion channels like the potassium channel and could modulate neurotransmitter release.  Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum.  Plays a role in several other cell functions including proliferation, survival and death.  Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:11149946, PubMed:14622179, PubMed:15571673, PubMed:15777781, PubMed:23332758, PubMed:9425306, PubMed:9603192).  Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (PubMed:25678561).  Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (PubMed:26792191).
What are the official names of this protein?
Sigma non-opioid intracellular receptor 1, Sigma 1-type opioid receptor, Sigma1-receptor, Sigma1R.
What is the protein family that this protein belongs to?
Belongs to the ERG2 family.
What are the subcellular locations of this protein?
Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane; Single-pass membrane protein. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Postsynaptic density membrane. Note=During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (By similarity). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum (PubMed:12730355). Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (PubMed:20167253).
Protein: HTPG_RICFE
Sequence: MTQEKKKFDAEVGKILNLMIHSLYSNKEIFMRELISNASDACDKLRYLSQSNSELTSGDSNFKITVKVDKDKGQIIIRDNGIGMNKDDLIENLGTIARSGTANFLKSLSGDSKKDNMLIGQFGVGFYSSFMVADKVTVTSRKAGEDKVHVWESDGLGEYIVSESDKEFTRGTEIVLHIKKEEDTFLDHFRLKHIVKSYSDHIAVPIYFFDEAGNNEIQLNSASALWTRSKSEITEEQYKEFYKSLSYAIDDPWITLHNKNEGAIEFTNLLFIPSSKTFDLFHPDRKRRVKLYIKRVFISDENIDLIPSYLRFLRGVVDSEDLPLNISRESLQHNSVLEKIKNAITKRVLGELKKKKEESPEEYNKFWANFGGALKEGLCEATTDHEKLLEVCIFRSALHNKMISLDEYIAGFKEGQNTIYYLSGDNPDKLLSSPQIEGLLSKNIDVLLFTDTVDDFWVNVNSEYKGHAIKSATRSDIDVEQTTSQSEEKNADSKKSDDEYKLLTDYFKETLGELVKEVKISKKLTSSPACLAVSDAAMDIRMERFLIEQKQIAAASAKNLELNPKNKIIEKIFNDLKANNKNNEELVNLIFDQACILEGEPVADTGAFSKRLNDIVQKAIL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBK53_ARATH
Sequence: MLSEDEKEKTPPSVMTSIPDDVIMECIAPRVPRYNHSMLSLVSKQFRSLVASPRLYKTRSLLGCTEDCVYVLIEDCILEVARWYSLNRRTKRNMPGTVENRLVLISSLPPMPTAASYVVVGSNIFVMGGRYDWNVEEWEAQPPSSIALCIDCRTHTTRLVADMPVGLMTNVSKVIDEKIYIVGRVWASATIVEFDLRTEKWADGTKPGWEADDRWLTSLSTTAGRGPSSFENNCDHKLMEDILMDKEEIKHYHLFDNECVMGNILYVYDRHKYILRTYDPKQRTWGVVKGLEKLPLGGDESYIVSRGKMLILFLIVVLEYDDDASFQKRELWCAEITVERREEGEIWGKVECCDLLLEGGLIIGSCLVVTL
What are the official names of this protein?
Putative F-box/kelch-repeat protein At3g10510.
Protein: PRMA_BEII9
Sequence: MSTDTSTVLRLDCEEAIAEQIADLVAETFSSDEAAASTFELKPAERKEGLPGWRVEIFLTASVSEEAVRALVATIAGAEVATAATSTPIEQRDWVAAALEGLAPVRAGRFLVHGAHRRDAVRVNDLAIEIEAALAFGTGHHGSTRGCLLMFDRVTKARHPKQILDLGTGSGILAMAAARLLHRKVEACDIDKDSVLAARGNARHNGVARLVRPVVASGTSHPAIHAGAPYDLVFANILARPLRGLAPSVARVTQRGADIILSGLLARDVPGVLSAYRIQGMALRDRLDLEGWVTLHLRKQ
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURQ_PICTO
Sequence: MDSKRAMVLRMEGTNNEEEAFLSLKRAGFEPEYVHINDLARKRKFIDDYNLMFIPGGFSAGDYIRAGAIFAARLRPFLSDINKFIDSGRFIIGVCNGFQVLTELGLFFNGDRKIALTVNESNRFECRFTYIRLSTKKVLSGLGNRPFQVPVAHLEGRVYCDNKTLDELIENDQIIFRYVDNNGNYSGYPWNPNGSIMNIAGITNDSGNVIGMMPHPERVYYPYQMSGNERNSDKGTGEIFFRILYNST
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAE1_PYRAE
Sequence: MLVLGVESTAHTFSLGLVLDGKILGQLGKTYLPPSGEGIHPREAADHHSKVAPVIFRQLLNAHGITASDIDVIAYAAGPGLGPALRIGAVFARALAIKLGVPLVPVHHGIAHIEVARYTTASCDPLVLLISGGHTLIAGFSEGRYRIFGETLDVAIGNAIDMFAREVGLGFPGVPAVEKCAESADRLVPFPMTIIGQDLSYAGLTTYALKLWKSGTPLPVVCKSLVEAAYYMLAEVTERALAFTKKRELVVAGGVARSKRLRGILEHVGREYGVAVKIVPDEYAGDNGAMIALTGYYAYRRGIRTTPEESFVKQRWRLDSVDIPWFYDLCEEVVLNTSTKRRP
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1, tRNA threonylcarbamoyladenosine biosynthesis protein Kae1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE8E2_BPV5
Sequence: MKLVMLLRPPPQTHRADTTDGLPGLQEEPRGGDGPTCSGPAPAIPDSPSRCLSRGFAGRDPGCHRNRHRVHPYILSGGQRILVTSSSSSTVQGPLSSGSSQHSQSRGRPPSPDSTETERARTPVNSDRQRAGEFDLLKGGCRPCCLIEGNGNKVKCLRFRLKKSHRSRFLDITTTFWATGDEGSDRQGNGTILITFTDTTQRDLFLGSVSIPGELSVRRITISTD
What is the function of this protein?
Plays a role in limiting the replication of viral DNA in keratinocytes.  Recruits the host NCoR/SMRT complex to viral replication foci to mediate repression of both viral replication and transcription.
What are the official names of this protein?
Protein E8^E2C.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E8^E2C protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: Y2720_DESPS
Sequence: MNCIQRPETDRPAWFVYIVQCADGTLYTGITTNIARRITEHNSSAKGARYTRSRRPVMLVYRETCRDRSEASKREYAIKQLSPTRKRTLVKASEKGFSAIYFPSYSIKGQ
What are the official names of this protein?
UPF0213 protein DP2720.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: RSMA_RUBXD
Sequence: MSPSLSGRTPRPKKRLGQHFLKDANTARIVAAGLTERDVVLEIGPGRGFLTAFLAERAGLVHAVEIDPDVLPELRRAVGARGNVRIHEADALRFDYGALSPPPNRLAANLPYNIASPLVLRLLEEVPSLERMRFMVQLEVALRMTARPGSKDYGAYAVLIQLLSRPEVAHRVSPRVFDPPPRVRSAVVELERRRDAPEDYRGVKELVAAAFRSRRKRLPNNLPGPLRERAEEALAGLGHGPDARAEELSPEDFVALYRRISP
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR6K2_HUMAN
Sequence: MESPNRTTIQEFIFSAFPYSWVKSVVCFVPLLFIYAFIVVGNLVIITVVQLNTHLHTPMYTFISALSFLEIWYTTATIPKMLSSLLSERSISFNGCLLQMYFFHSTGICEVCLLTVMAFDHYLAICSPLHYPSIMTPKLCTQLTLSCCVCGFITPLPEIAWISTLPFCGSNHLEHIFCDFLPVLRLACTDTRAIVMIQVVDVIHAVEIITAVMLIFMSYDGIVAVILRIHSAGGRRTAFSTCVSHFIVFSLFFGSVTLMYLRFSATYSLFWDIAIALAFAVLSPFFNPIIYSLRNKEIKEAIKKHIGQAKIFFSVRPGTSSKIF
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 6K2, Olfactory receptor OR1-17.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UREF_MYCBO
Sequence: MTSLAVLLTLADSRLPTGAHVHSGGIEEAIAAGLVTGLATLEAFLKRRVRTHGLLTASIAAAVHRGELAVDDADRETDARTPAPAARHASRSQGRGLIRLARRVWPDSGWEELGPRPHLAVVAGRVGALSGLAPEHNALHLVYITMTGSAIAAQRLLALDPAEVTVVTFQLSELCEQIAQEATAGLADLSDPLLDTLAQRHDERVRPLFVS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSZ2_HALS3
Sequence: MQDIVQDALDNAEAEQREMDGDGDGDEFGDPRIVIVGCGGAGNNTVNRLYNIGVEGADTVAINTDKQHLKMIKADTKILVGKSLTNGLGAGGDPSMGERATEMAQGTIKEVLGDADLVFVTAGMGGGTGTGAAPVVSKIAKEQGAIVVGMVSTPFNVERARTVKAEEGLEKLREKADSIIVLDNNRLLDYVPNLPIGKAFSVMDQIIAETVKGISETITQPSLINLDYADMTAIMNQGGVAVMLVGETQDKNKTNEVVKDAMNHPLLDVDYRGASGGLVHITGGPDLTLKEAEGIADNITERLDASANVIWGARIQESYKGKVRVMAIMTGVQSAQVLGPSTQKQADKSRRELQDVDSKQRAADDAGAGGFGGAHSDGGQDEVEQENGLDVIR
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.  Overexpression causes significant changes in cell morphology (PubMed:8631708).
What are the official names of this protein?
Cell division protein FtsZ 2.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: DNAJ2_AQUAE
Sequence: MASSTKKDYYEILGVPRNASQEEIKKAYRRLVRKYHPDICKKPECEEKFKEINEAYQVLSDPEKRKLYDMYGHAAFEGAGAQQRVETTEIPPIEEILREFFDFDIGSIFERATGRRRARRRRSVKGEDIVVPVEITLEEAFKGTTVPIEVEREVPCSACGGTGYDESKSRTCPTCGGRGETVQGNWFFQVRQTCPTCGGEGVIYENCHACTGRGYGLVKETIKVKIPPGVRDGSKLVVEGKGHAGRYGGPPGDLYIIVKVKPHKIFERKGDDLYVDVNITYPEAVLGTEVEVPTLDGEKVKVKIPPGTKEGELIKVPGKGMPRLKGSGRGDLYVRVHIDVPKIGVLSKLLGDGKKVEELLKQLQEVLPKPERIVER
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ 2.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HAP1_YEASX
Sequence: MSNTPYNSSVPSIASMTQSSVSRSPNMHTATTPGANTSSNSPPLHMSSDSSKIKRKRNRIPLSCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYMEQTWAEEAEKELLKDNELKKLRERVKSLEKTLSKVHSSPSSNSLKSYNTPESSNLFMGSDEHTTLVNANTGSASSASHMHQQQQQQQQQEQQQDFSRSANANANSSSLSISNKYDNDELDLTKDFDLLHIKSNGTIHLGATHWLSIMKGDPYLKLLWGHIFAMREKLNEWYYQKNSYSKLKSSKCPINHAQAPPSAAAAATRKCPVDHSAFSSGMVAPKEETPLPRKCPVDHTMFSSGMIPPREDTSSQKRCPVDHTMYSAGMMPPKDETPSPFSTKAMIDHNKHTMNPPQSKCPVDHRNYMKDYPSDMANSSSNPASRCPIDHSSMKNTAALPASTHNTIPHHQPQSGSHARSHPAQSRKHDSYMTESEVLATLCEMLPPKRVIALFIEKFFKHLYPAIPILDEQNFKNHVNQMLSLSSMNPTVNNFGMSMPSSSTLENQPITQINLPKLSDSCNLGILIIILRLTWLSIPSNSCEVDLGEESGSFLVPNESSNMSASALTSMAKEESLLLKHETPVEALELCQKYLIKFDELSSISNNNVNLTTVQFAIFYNFYMKSASNDLTTLTNTNNTGMANPGHDSESHQILLSNITQMAFSCGLHRDPDNFPQLNATIPATSQDVSNNGSKKANPSTNPTLNNNMSAATTNSSSRSGSADSRSGSNPVNKKENQVSIERFKHTWRKIWYYIVSMDVNQSLSLGSPRLLRNLRDFSDTKLPSASRIDYVRDIKELIIVKNFTLFFQIDLCIIAVLNHILNVSLARSVRKFELDSLINLLKNLTYGTENVNDVVSSLINKGLLPTSEGGSVDSNNDEIYGLPKLPDILNHGQHNQNLYADGRNTSSSDIDKKLDLPHESTTRALFFSKHMTIRMLLYLLNYILFTHYEPMGSEDPGTNILAKEYAQEALNFAMDGYRNCMIFFNNIRNTNSLFDYMNVILSYPCLDIGHRSLQFIVCLILRAKCGPLTGMRESSIITNGTSSGFNSSVEDEDVKVKQESSDELKKDDFMKDVNLDSGDSLAEILMSRMLLFQKLTKQLSKKYNYAIRMNKSTGFFVSLLDTPSKKSDSKSGGSSFMLGNWKHPKVSNMSGFLAGDKDQLQKCPVYQDALGFVSPTGANEGSAPMQGMSLQGSTARMGGTQLPPIRSYKPITYTSSNLRRMNETGEAEAKRRRFNDGYIDNNSNNDIPRGISPKPSNGLSSVQPLLSSFSMNQLNGGTIPTVPSLTNITSQMGALPSLDRITTNQINLPDPSRDEAFDNSIKQMTPMTSAFMNANTTIPSSTLNGNMNMNGAGTANTDTSANGSALSTLTSPQGSDLASNSATQYKPDLEDFLMQNSNFNGLMINPSSLVEVVGGYNDPNNLGRNDAVDFLPVDNVEIDGLVDFYRADFPIWE
What is the function of this protein?
Regulation of oxygen dependent gene expression.  It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c.  In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes.  Binds to the sequence 5'-CGGNNNTNNCGG-3'.  Is non-functional in terms of iso-1 cytochrome c expression in strain S288c and its derivatives.
What are the official names of this protein?
Heme-responsive zinc finger transcription factor HAP1, CYP1 activatory protein, Heme activator protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: KATG_HAHCH
Sequence: MSDSKCPFHHAPAEGTSNRDWWPNQLRLEILHQRSALSNPLGEEFNYAEAFKSLDLAAIKQDLTALMTDSQDWWPADFGHYGPLFIRMAWHSAGTYRTGDGRGGGGTGNQRFAPLNSWPDNVNLDKARRLLWPIKQKYGQKISWADLMILAGNVALESMGFKTFGFGGGRADIWEPEQDIYWGAEKTWLDDNRYSGDRDLENPLAAVQMGLIYVNPEGPNGNPDPVAAAKDIRETFARMAMDDEETVALIAGGHTFGKTHGAGDAANVGPEPEAAGLEEQGLGWRSSYGSGKAGDAITSGLEVTWTETPTQWSNNFFENLFGYEWELTKSPAGAHQWVPKGGAGADKIPDAHDPSKRHVPTMLTTDLSLRFDPAYEKISRRFYENPDQLADAFARAWFKLTHRDMGPRARYLGPEVPAEELIWQDPIPAVDHPLINDQDISALKSKILTSGLSVAQMVSTAWASASTFRGSDMRGGANGARIRLAPQNEWEVNQPDQLAQVLKTLEGVQAEFNSAQSDGKKVSLADIIVLAGCAGVEKAAQNAGHTIKVPFSPGRMDASQEQTDIEAFEVLEPIADGFRNYMKGKYAVSPEELLVDRAQLLTLTAPEMTVLIGGMRVLNANVGQSKHGVFTQRPESLTNDFFVNLLDMGTVWKATSKEEDLFEGRDRVTGDLKWTGTRIDLVFGSNSQLRALAEVYASSDAQERFLKDFVAAWTKVMNLDRFDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: ECHD2_MOUSE
Sequence: MLRVLPRALRLPCSWRFSGARDCASHATTRTPEIQVQALTGPNQGITEILMNRPNARNALGNVFVSELLEALAQLREDQQVRVLLFRSAVKGVFCAGADLKEREQMSDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQNEEGNAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPKFVGK
What are the official names of this protein?
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: BEDC2_PSEPU
Sequence: MIDSVNRADLFLRKPAPVALELQNEIEQFYYWEAKLLNDRRFDEWFALLAKDIHYFMPIRTTRIMRDSRLEYSGLRDYAHFDDDATMMKGRLRKITSDVSWSENPASRTRHIVSNVMIIPTEVEGEYEISSTFIVYRNRLERQLDIFAGERRDRLRRNKGEAGFEIVNRTILIDQSTILANNLSFFF
What is the function of this protein?
The beta subunit may be responsible for the substrate specificity of the enzyme.
What are the official names of this protein?
Benzene 1,2-dioxygenase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
Protein: NFUA_BUCAI
Sequence: MINISKKAQEHFTSLLSNEPENTQIRVFIVNPGTPNAECGVAFCPENEIELSDIQLKYDGFFVYVNKDTISYLKNSVIDLVTDKIGSQLTLKAPYAKNNFSKKVSSSLEEKVKCFLNLEINPQLSMHGGRVELIKIDKNGIAAIQFSGGCNGCSMIGSTLKETVEKKLLSSFSEIKKVYDETHHLHGQHSFY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: RL11_HYPBU
Sequence: MGIRVINVKVRGGEAKPAPPLAPAIEKLGLDVNKVVEDINKATEKYKGFEVAVKLIVDENTKEYEIEVKPPTTTELLLKAVGASEPSGDPMHQKIGDLPFEKIVEIAILKKPSLNAKTLKAAVKTILGSARSIGITVDGKDPKQVTKEVEEGLYDAVLAKYEEEWEKA
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: GLMU_RUEST
Sequence: MSTALVILAAGKGTRMNSDLPKVLHQIAHAPMLEHAMRAGGALDPERTVVVAGHEAEMVRAATAEIAPEATVVLQEEQLGTGHAVLQARAALEGFRGDVVVLYGDTPFVSAETLERMIEARSRADLVILGFEAADPARYGRLIMQGESLEKIVEFKDASDAERAITFCNSGLMACNAEVMFGLLDQVGNDNASGEYYLTDLVELARAEGLSVTAVSCPEAETLGINSRADLAAAEAVFQAHARAELLDIGVTLTAPETVHLAFDTIIGRDTVIEPNVVFGPGVTVESGALIRAFSHLEGCHVSRGAKVGPYARLRPGAELAEDTHVGNFVEIKNAEIAAGAKVNHLTYIGDASVGEATNIGAGTITCNYDGVMKHRTEIGARAFIGSNTCLVAPVTVGDEAMTATGAVITKDVADGDLAIARVQQTNKPGRARKLMDMLRAKKAAKAKG
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_KARMG
Sequence: MLKNDDTIVAIATPSGYGAIAVIRISGNNSIKIIKKIFCSFSKNQIETNYIHLGYIKYKKQIIDKVLIFLFKKPKSYTGEDIVEISCHGSIYIQNKLLSIIIDQGARLANPGEFTLRAFLNGKIDLCQAESILDIVNSETFFSHKFAINQMRGNISLLIRKLSKEIINLLSLIEFELDFSEENCNFINYLEFKKMLYNIIKKLKTLIRSFKIGNALKNGISVSIIGCPNVGKSTLFNKLLKYERSIVSNIAGTTRNYIEDSLIINGIKFRFIDTAGINNNTKDYIEKLGIKKTYSKINKSDLILYVFDDLNEKFILKKVKSLQEKYPKKKIFIIINKYDLIKKKIKEFNYKKIFKISAKYGYGVNNLLSEITFFSKKITSLKENTIVITQTRHYESFKKAIFYLYKVKKNLYSISPEFLSIDIRTALDYLGKVTGEVTNEDILSNIFSKFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
Protein: RS6_PSE14
Sequence: MRHYEIIFLVHPDQSEQVGGMVERYTKLIEEDGGKIHRLEDWGRRQLAYAINNVHKAHYVMLNVECTGKALAELEDNFRYNDAVIRNLVIRRDEAVTGQSEMLKAEENRSERRERRDRPEHSDSADGDDGDNSDVSDNADE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: B9D1_MOUSE
Sequence: MAAASPSVFLLMITGQVESAQFPEYDDLYCKYCFVYGQDWAPTAGLEEGISQIASKSQDVRQALVWNFPIDVTFKSTNPYGWPQIVLSVYGPDVFGNDVVRGYGAVHVPLSPGRHKRTIPMFVPESTSTLQKFTSWFMGRRPEYTDPKVVAQGEGREVTRVRSQGFVTLLFNVVTKDMKKLGYDTGPVDTQGVLGPSLPQGNPQ
What is the function of this protein?
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.  Required for ciliogenesis and sonic hedgehog/SHH signaling.
What are the official names of this protein?
B9 domain-containing protein 1, Endothelial precursor cells protein B9.
What is the protein family that this protein belongs to?
Belongs to the B9D family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Protein: CLD16_HUMAN
Sequence: MRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYAVDTRV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.  Involved in paracellular magnesium reabsorption.  Required for a selective paracellular conductance.  May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients.  Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
What are the official names of this protein?
Claudin-16, Paracellin-1, PCLN-1.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: RS8_SYNP2
Sequence: MAANDTISDMLTRIRNACMVQHDNTKVPMTRMTRNIAEVLKDEGFIENYTEAGEGIEKHLVISLKYKGRNRQPIIQKLQRVSKPGLRVYSNHKDLPRVLGGIGIAIISTSKGVMTDRQARKEGIGGEILCYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.