PharMolix/UniProtQA huggingface dataset:
Protein: SDHE_FRATT
Sequence: MLIKNNDLIFSSVDKIKYSARRGMLELDIILAPYLNNCYMHEDLANKKLFVEFLTSEDSDMFDWLFKGVTPPQRYQQLIDKIIKEKKKFNQTKLK
What is the function of this protein?
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins.  Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
What are the official names of this protein?
FAD assembly factor SdhE.
What is the protein family that this protein belongs to?
Belongs to the SdhE FAD assembly factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1421_MYCTU
Sequence: MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFMEASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLRDSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMGLLRSDQQLSVRALHRDLGRE
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Rv1421.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: CCNB2_MOUSE
Sequence: MALLRRPTVSSDLKNIDTEVIPKAKSHVTIRRAVLEEIGNKVRNRTTQVAKKPQNTKVPALPTKVTNVNKQPKPTASVKPVQMEALAPKDRPPAPEDVSMKEESLCQAFSDALLCKIEDIDNEDRENPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGRDINGRMRAILVDWLVQVHSKFRLLQETLYMCIAIMDRFLQAQLVCRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQHTLAKYLMELTLVDYDMVHYHPSQVAAAASCLSQKVLGQGKWNLKQQYYTGYMESEVLEVMQHMAKNVVKVNDNRTKFIAVKNKYASSRLLKISTIPQLNSKIIKDLASPLLGSP
What is the function of this protein?
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
What are the official names of this protein?
G2/mitotic-specific cyclin-B2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: CSRA_YERPB
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKSQPTTY
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_LIMRD
Sequence: MRLMGLDVGSKTVGISVSDPLGWTAQAVEIIPIDEENEIFGIDRVAELVKKEQVAGFVIGLPKNMNNTEGPRVEASQHYGKLLQQRFPDIPIDFQDERLTTVEAHRMLVEEADISRAKQKKVIDEVAATFILQSYLDRHGRLVNKLK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLBT_CAUVN
Sequence: MPLKLSLKPGEKFVLNGAVVQNGDRRGVLVLQNKASVLREKDIMQPDQVTTPARHIYFPVMMMYLDEVGAEKFYEEFATRLNEFMGVVRNPVVLQDCIAISKHVMAREYYKALMLSRKLIEYEDERLGHVSSGVSAGGDAG
What is the function of this protein?
Has a post-transcriptional repressor function in flagellum biogenesis.  Associates with the 5'-UTR of fljK mRNA and promotes its degradation.
What are the official names of this protein?
Probable flagellum biosynthesis repressor protein FlbT.
What is the protein family that this protein belongs to?
Belongs to the FlbT family.
Protein: HIS5_ACAM1
Sequence: MPIIAVIDYDMGNLHSACKGLQEAGTQTIVSDRPEDLVSADAVVLPGVGAFDPAMQHLRSRQLIPVIQDILASGKPFLGICLGLQILFEGSEEGTEAGLGIIPGTVKRFQSEPGITIPHMGWNQLEYQQPDLPLWRHSPAQPWVYFVHSYYVDPVDPTVKAATVTHGTQTITAAIARDNLMAVQFHPEKSSTFGLQILANFVEQVQATLATPAV
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPAL_BOVIN
Sequence: MAGRRFGWSRAALLQLILGVNLMVMPRTQARTLRFVTLLYRHGDRSPVKAYPKDPHQEDKWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPDGIQRFNPNISWQPIPVHTVPVAEDRLLKFPLGPCPRFEQLQNETRRMPEYQNESVQNAQFLDMVANETGLTDLSLETVWNVYDTLFCEQTHGLPLPPWASPQTMQRLSRLKDFSFRFLFGIYKQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALHMALGVYNGEQAPYASCHMFELYQEDSGNFSVEMYFRNESHRAPWPLTLPGCSHRCPLQDFLRLTEPVVPKDWLQECQLAGGPADTEVIVALAVCGSILFLLIVLLLTVLFRVQAQPPGYRHVPDGEDHA
What are the official names of this protein?
Lysosomal acid phosphatase, LAP.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass membrane protein; Lumenal side. Lysosome lumen. Note=The soluble form arises by proteolytic processing of the membrane-bound form.
Protein: MNMG_RICRO
Sequence: MLKYDVIVIGGGHAGVEAAAASARLGVPTLLITLKPENLGEMSCNPAIGGIAKGTLVKEIDALDGLMGYVIDQAGIHYKMLNETRGPAVWGPRAQADRKLYKKAMYQILTNYPNLDILYGKVEDIEIKSSKIEAVILNNGSKILCQKIILTTGTFLSGLIHIGQKKIPAGRVDEEPSYGLSNTLKQIGFKLARLKTGTPPRIDGRTIDYSKTILQPGDKIPRPFSELTNIVNVSQINCFITKTTSETHDIIRENLDKSAMYSGQIEGIGPRYCPSIEDKIVRFSTKSEHRIFLEPEGLDDYTIYPNGISTSLPEDVQHKLIKTIPGLENVKVLRPGYAIEYDYVDPREISVTLETKKIAGLYLAGQINGTTGYEEAAGQGIIAGINAALAVKDQAPFMLTRANSYIGVMIDDLTTFGTIEPYRMFTSRSEYRLSLRADNSDLRLTELGMNIGVVSEKRKKIFTKKCEDIEKIKSLLNTLSLTTSKLAKMGIQVAQDGTYKTVLDLFKIPNFNVEQAIKIFPMLKETQNNNILQLLYIEAKYASYLTRQQADINLFQSEEAQFIPKNIDYFKIPSISLEIQEKLSAHKPTTIGVARRIPGITPAAITAIIIYLKTKYSDGSST
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_BRUA2
Sequence: MAKAATPKTTAAAEAKPAAKAPAKKAAPKTTAAAKPAATKSGAPKAAAAGAIGHITQVIGAVVDVKFPEGQLPLILNALEVDNQGHRLVLEVAQHLGEDTVRTIAMDATEGLVRGQEARDTGEPIMVPVGVETLGRIMNVIGEPVDEAGPIKTKATRAIHQNAPEYIEQSTEAEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVNKLGGGEGSKAALVYGQMNEPPGARARVALSGLTVAENFRDQGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGAMQERITTTTKGSITSVQAIYVPADDLTDPAPATSFAHLDATTVLSRSIAEKGIYPAVDPLDSTSRMIDPKVVGEEHYAVARQVQSILQRYKALQDIIAILGMDELSEEDKLTVARARKIERFLSQPFFVAEVFTGSPGKLVDLADTIKGFKGLCAGDYDHLPEAAFYMVGSIEEALEKAKKLAAEAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LMBD1_EMENI
Sequence: MILLQTSLIWVVYAVVVVVLFAVASVFIYVYQSPRDRSPSVTLTCIVAITSLLATILLLPVDVALVSSTVSSSVGQRKDWATPEVVDRITFSLTLVYYILYSLDILLCLLVVPFVYFWYEEYDEVAAQTGEQSSGQRFWGASKYTLSFIAILIILFLVGVFVPISRANGGNGLDPFKSLLGENRGERALTFALGLLITIGMYVYALHTSTGLAVLPIRLIKGGPRLSNAGSWNATFTVQLDSNRERRRQLEGRCGGNFDHLSSKDRRELDALIREERTLIRRQRLAQEADGKGNALLPRMWFRLEAFFRPFRRLVGLILLLLVLLIWVSMILTASDKAKNSICKRHCGYVLGHINIFNPINEIFVQSAKLFPIDYAIFTMLVLLLFFGTVVGIATVGIRFLWISIFRIRLGHTSPQALLVMTAILMLSILALNYSISMIVAPQYATFGPQTFCDRLSGSSVLPELQCVVKRCSEAFGSDAAKKVCTPSVASTVLNRVTVSFPFFGAIFFWSQFAFIGVYLLALITSLLRSPKLDEQQLDEDAEEAEEEALLSGSRRNMDDRWQSIVGRASRSEDT
What is the function of this protein?
Probable lysosomal cobalamin transporter.  Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).
What are the official names of this protein?
Probable lysosomal cobalamin transporter.
What is the protein family that this protein belongs to?
Belongs to the LIMR family. LMBRD1 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: HAP40_HUMAN
Sequence: MAAAAAGLGGGGAGPGPEAGDFLARYRLVSNKLKKRFLRKPNVAEAGEQFGQLGRELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQERDARQRLVCPAAYGEPLQAAASALGAAVRLHLELGQPAAAAALCLELAAALRDLGQPAAAAGHFQRAAQLQLPQLPLAALQALGEAASCQLLARDYTGALAVFTRMQRLAREHGSHPVQSLPPPPPPAPQPGPGATPALPAALLPPNSGSAAPSPAALGAFSDVLVRCEVSRVLLLLLLQPPPAKLLPEHAQTLEKYSWEAFDSHGQESSGQLPEELFLLLQSLVMATHEKDTEAIKSLQVEMWPLLTAEQNHLLHLVLQETISPSGQGV
What is the function of this protein?
RAB5A effector molecule that is involved in vesicular trafficking of early endosomes (PubMed:16476778).  Mediates the recruitment of HTT by RAB5A onto early endosomes.  The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778).
What are the official names of this protein?
40-kDa huntingtin-associated protein, HAP40, CpG island protein, Factor VIII intron 22 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Early endosome. Nucleus, nuclear body. Note=Diffuse presence in the cytoplasm and accumulation in the nucleus (PubMed:16476778). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity). Colocalized with HTT in endosomes (PubMed:16476778). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity).
Protein: Y186_HAEIN
Sequence: MTYTTAKAAEKIGISAYTLRFYDKEGLLPNVGRDEYGNRRFTDKDLQWLSLLQCLKNTGMSLKDIKRFAECTIIGDDTIEERLSLFENQTKNVKCQIAELKRYLDLLEYKLAFYQKAKALGSVKAVNLPQIPETS
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator HI_0186.
Protein: RUVB_XANOP
Sequence: MDQRIIASSSTREDDAADASIRPKRLADYLGQQPVREQMEIYIQAAKARGEAMDHVLIFGPPGLGKTTLSHVIANELGVSLRVTSGPVIEKAGDLAALLTNLQPHDVLFIDEIHRLSPVVEEVLYPAMEDFQIDIMIGDGPAARSIKIDLPPFTLIGATTRAGLLTAPLRDRFGIVQRLEFYSPQELTRIVIRSAAILGIDCTPEGAAEIARRARGTPRIANRLLRRVRDYAQVKAAGHIDLPVAQAAMQMLKVDPEGFDELDRRMLRTIVEHFDGGPVGVESLAASLSEERGTLEDVIEPYLIQQGFLIRTARGRMVTTKAYLHLGLKPPRDRAPGIGEPGDLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: DARB_BACSU
Sequence: MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTGYTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDPIMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK
What is the function of this protein?
Involved in the c-di-AMP-dependent regulation of the bacterial stringent response (PubMed:33619274, PubMed:35130724).  Modulates the activities of at least two enzymes under conditions of potassium limitation (PubMed:33619274, PubMed:35130724).  Apo-DarB regulates the activity of the GTP pyrophosphokinase RelA by interacting directly with RelA, leading to stimulation of (p)ppGpp synthesis and induction of the stringent response (PubMed:33619274).  Apo-DarB also regulates pyruvate carboxylase (PYC) at two levels: directly at the protein level by binding to the enzyme and stimulating the synthesis of oxaloacetate and indirectly, by interaction with RelA, which leads to activation of the stringent response and to the increased expression of the pycA gene (PubMed:35130724).  Stimulation of these enzymes by DarB is prevented in the presence of cyclic di-AMP (c-di-AMP) (PubMed:33619274, PubMed:35130724).
What are the official names of this protein?
Cyclic di-AMP receptor B, c-di-AMP receptor B, c-di-AMP receptor protein DarB.
Protein: SODM_HALHI
Sequence: GYVNGLESAEETLAENRESGDFGSSAAAMGNVTHNGCGHYLHTLFWENMDPNGGGEPEGELLDRIEEDFGSYEGWKGEFEAAASAAGGWALLVYDPVAKQLRNVPVDKHDQGALWGSHPILALDVWEHSYYYDYGPARGDFIDA
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: LUXU_VIBPA
Sequence: MTILNQQKIDELSIEIGSDNVPVLLDIFLGEMDTYIDNLSQLEGSERLMYLKEISHALKSSAASFGADSLCELAMSIDKKAKSGELVEQGSEVNTMLDRLNETRDAYRSWTQ
What is the function of this protein?
Phosphorelay protein which receives a sensory signal from a sensor kinase and transmit it to LuxO.  At low cell density, a phosphoryl group is transferred from the sensor kinase, probably on His-56 and this phosphoryl group is further transferred to LuxO.
What are the official names of this protein?
Phosphorelay protein LuxU.
Protein: RSMH_BRUC2
Sequence: MASLGGDNSQAEGAEVRHVPVLIAEVIDALKPAPGAVIVDGTFGAGGYTRRILETGADVIAIDRDPTAIEAGRAMEKEFPGRLNLVESRFSALDEAVARMSGAGKKVDGVVLDIGVSSMQIDEAERGFSFQKDGPLDMRMSSRGPSAADAVNRLKTGDLARIFNFLGEERHAGRIARMIEKRRAAKPFTRTLDLANAIETLVGRNPKDRIHPATRVFQALRVYVNDELGELARALLAAERILKPGGRLVVVTFHSLEDRMVKRFFADRAGGSAGSRHMPETHMRLPSFTPAVKGAVGPTPEEEERNPRARSAKLRAGIRTENPPLEDDLSLFGLPKLPETNELARS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_MYCS5
Sequence: MKESSLKLAKKVTVSEITNKISSAKAIAFAEYRGLTVAQLKEMRVEAKKVGVELKVYKNRLFKLATDKLGYDLSSFLVGANIFAFSNDDDMSAAKLLVKFAKKHKEFVVLKAGTFEGKVVDTQELKKVAALPSYEEALTILARSLMAPLQQLSLGLKLVSEQKSN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y5504_RHILO
Sequence: MKDLLGLMGKAKEMQAKFQAMQDEIATVESVGQAGGGLVSVILSGKFEMKSLKIDPSLFKEDEVEILEDLILAAHNDAKAKVEQIMQEKTKALTSGLPIPPGMKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein mlr5504.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DHE1_ORYSJ
Sequence: MNALAATSRNFKQAAKLLGLDSKLEKSLLIPFREIKVECTIPKDDGTLASYVGFRVQHDNARGPMKGGIRYHHEVDPDEVNALAQLMTWKTAVANIPYGGAKGGIGCSPGDLSISELERLTRVFTQKIHDLIGIHTDVPAPDMGTNSQTMAWILDEYSKFHGYSPAVVTGKPVDLGGSLGRDAATGRGVLFATEALLAEHGKGIAGQRFVIQGFGNVGSWAAQLISEAGGKVIAISDVTGAVKNSNGLDIAKLMKHSSENRGIKGFDGGDAIDPRSLLTEECDVLIPAALGGVINKDNANEIKAKYIIEAANHPTDPEADEILSKKGVLILPDILANSGGVTVSYFEWVQNIQGFMWDEEKVNNELKTYMTRGFRDVKEMCRSHHCDLRMGAFTLGVNRVARATVLRGWEA
What are the official names of this protein?
Glutamate dehydrogenase 1, mitochondrial, OsGDH1.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HMUD1_BPSAV
Sequence: MSYSLKGLLKRPVHLFVKPPAVEGEYPARGELYYVKGSNGSGKSTVPSYLAENDPQAYVVTYNGKIMLTVCPSYNIICIGKYDKSKSKGVDSLKDTEQMLFALSIADQPEYLKYDVLFEGIIPSTLLSSWIPRLTRPPRELVVLFMDTPLETCVSRVKSRNGGADFNESLVVEKWERVHDHSQRHKGLFPTVPAGMMKSNGLTIEQAVFAFLNRDFGSID
What is the function of this protein?
Phosphorylates 5-hydroxymethyluracil (5hmdU) into 5-phosphomethyl-2'-deoxyuridine (5- PmdU) on DNA as a step in the pathway leading to thymidine hypermodifications in the viral genome (PubMed:34522950).  The phosphate is added internally to the DNA polymer (PubMed:34522950).  As a final result of the pathway of hypermodification, 5-aminoethoxy-2'-deoxymethyluridine (5-NeOmdU) substitutes for about 40% of the thymidines in the viral DNA (PubMed:34522950, PubMed:29555775).  These modifications probably prevent degradation of viral genome by the host restriction-modification antiviral defense system (PubMed:34522950).
What are the official names of this protein?
5-hmdU DNA kinase 1, 5-hydroxymethyluracil DNA kinase, P-loop kinase, gp67.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family. 5-hmdU DNA kinase subfamily.
Protein: HEM1_BACC7
Sequence: MHILVVSVNYRTAPVEFREKLTFQAAELEQAMTTLQNQKSVLENVIVSTCNRTEVYAVVDQLHTGRYYIKKFLADWFQLEIEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQIKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGELTDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEIMAEKYMGHAKPLSELQCALLEADILISSTGASDYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDIDDLQGVVEANRAERLKEAEKIQFMIEEEIVVFKTWLSTLGVVPLISALRDKALAIQSETMESLERKIPTLSDRERKVISKHTKSIINQLLKDPILVAKEIAAEEGADEKLALFAKIFDLEMEDVESRAEEVEHKRAWTPSVPSL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: TAM_METRJ
Sequence: MADWNPALYTRFEDERTRPAAELLARVPLEAPRLAIDLGCGPGNSTALIAARFPDAEVIGLDTSPAMLESARARLPRLAFALADAATWTPERAPDLIYANAVLQWLPDHATLLPRLFGLLAPGGVLAVQMPDNLAEPTHRLMRAVAASGPWAAAIGDPAVAGRLGRMLEPAAYYDLLAPAAAEVDVWRTAYHHRMADAAAIVDWVRATGLRPFLDPLDPEHRAGFLDAYTRAIDGAYPPRSDGRRLLAFPRVFVVARKAS
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOF_BURM9
Sequence: MNPLATLEQGLADIDAQGLRRCRRVADTACGAHMTVDGRAIIGFASNDYLGLAAHPRLVEAFAEGARRYGSGSGGSHLLGGHSRAHATLEDELAAFSGGFSDAPRALYFSTGYMANLAALTALAGRGATIFSDALNHASLIDGARLSRANVQIYPHGDADALDARLRACDAPTKLIVSDTVFSMDGDVAPLARLVALAETHGAWLVVDDAHGFGVLGPQGRGALAAHGLRSPNLVYVGTLGKAAGVAGAFVVAHETVIEWLVQRARSYIFTTAAPPSVACAVSASLAVIASDEGDARRAHLGALIKRTRAILRATHWQPVDSHTAVQPLVIGSNEATLAAMAALDAQGLWVPAIRPPTVPAGTSRLRISLSAAHSFDDLARLEAALVTPIGAAA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: RS7_PYRNV
Sequence: MSSTIFGEQLPKYSRVEYVGDVPIVEECPRDVKTINGEPPLLFGKWSFENVVVRDPGLRRYICLKPVVLPHTEGRYQNYRFGKARIPIVERLINLMMRPGRNAGKKHKAYNIVKRAFDIVYYKTGQNPIQVFIDAIVNTAPREEITRIIMGGIAYSVSVDVSPQRRLDLALRWITEGARACSFNNPKPIEECLADELVAAAANDPKSYAVRKREELERIAAASR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: CEP3_EHV2
Sequence: MGILLSICRRRHDPLTDVEGQPINVREEFEMFEEGDEATEACVFLNPNMGTDEYDEEDEGGDGGEGREPQPEVKTTPYPKRKKIKLKADVL
What is the function of this protein?
Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes.  Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.
What are the official names of this protein?
Cytoplasmic envelopment protein 3.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.
What are the subcellular locations of this protein?
Virion tegument. Virion membrane; Lipid-anchor. Host cell membrane; Lipid-anchor; Cytoplasmic side. Host Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Note=Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: ZIPA_PHOPR
Sequence: MQELRLVLIIVGALAISALLLHGLWTSRKEKPAKFGEKPLGKLDDSNRDTEGFDHTGVGSVRIINNAPEKDVAVHTSQRKEPELHFGEKIHADPLMDSPASVQVIDDMADLPRMSATSEKIEPKFSSDSVVPDPVATAVEEEPVRIAVEQPIQSEPASVVSDYTEVLNTPISDIPEVSEQEVKPEENKVLEPEPVIANVVPEPEPEPEPEPEPVLAPSYIALSVHARNGEMLQGAKLFQCLEQHNLIFGENAVYHRHADLAGTEPVLFSATNMVQPGNFPEDGGYNFETPGVSFYLMLPCYGSAKNNFNLMLQTVQRIADDLNADVLDHERAMVTPNRIAQYREKAKLYSQA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.