PharMolix/UniProtQA huggingface dataset:
Protein: SQRD_ACIF2
Sequence: MAHVVILGAGTGGMPAAYEMKEALGSGHEVTLISANDYFQFVPSNPWVGVGWKERDDIAFPIRHYVERKGIHFIAQSAEQIDAEAQNITLADGNTVHYDYLMIATGPKLAFENVPGSDPHEGPVQSICTVDHAERAFAEYQALLREPGPIVIGAMAGASCFGPAYEYAMIVASDLKKRGMRDKIPSFTFITSEPYIGHLGIQGVGDSKGILTKGLKEEGIEAYTNCKVTKVEDNKMYVTQVDEKGETIKEMVLPVKFGMMIPAFKGVPAVAGVEGLCNPGGFVLVDEHQRSKKYANIFAAGIAIAIPPVETTPVPTGAPKTGYMIESMVSAAVHNIKADLEGRKGEQTMGTWNAVCFADMGDRGAAFIALPQLKPRKVDVFAYGRWVHLAKVAFEKYFIRKMKMGVSEPFYEKVLFKMMGITRLKEEDTHRKAS
What is the function of this protein?
Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone.  Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.
What are the official names of this protein?
Sulfide-quinone reductase, SQR, Sulfide:quinone oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the SQRD family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: NUTM2_MOUSE
Sequence: MDLSRQTWLLSKPIGIVSEASSLGQNMTINPGASLPTFATLPVLPPAPQPVPQLFWEPPAPLVTAGISPGNPLVLSALPGMPLVAEGGSTALSAAVPLNIVQLGTLGQPVQPVHNTNIVLTQVPLTCNIPGTQGVGMGFMTTPAANNFINTRIASTVQPQEGTWILGPHPPTTQQVVQLVPVKSPVNSAQPPKGAYGESGPANIQTNSPENYLSKPDSVYGNFRRWQHIKTLVQRHLPQTTDVAAFSCFLIPVLRSLARRKPTMNVEEGLWRGLQEWQCTSNYDRMIFYEMAEKFTEFESAEEMENSRLEIIRSIQYQVVATIPRQDPPRLPAPEVAEEPECTSMKTVHQTDPAHLPELRPQKLQKTETPMEIPPEAVREYMEIMDWLEGFPQSFTGEAKEKEEDENNGPEQEGDDLYSDAELLSYIDELCSQKHFVEQVEAIINPQFVAEILSTKPEIDILALTKVLEHEEELTVDQLLEKPCPALKKRGVERAPPNPGAPQIPASTSVPSVCQDAERDEHGVQRGASAQTGSSRMASLDQQCLEVTSAEIWGPKPATVFPSNQSSPSLVDVRYTGIPRGRGTYNQSPGSRCVRSFRVASAIEDLHRSLARTIEDKEELHSLSFLLASQYRLVPWKVPHQVCPYTDLSDSESIPSPCPKLRGLSPDLCSIAKSKKRALFGSLVPMAKRPNLGPGHGVSEGPLSALELAHLSQPQKRKHEPLGTHKRKRKKRH
What are the official names of this protein?
NUT family member 2.
What is the protein family that this protein belongs to?
Belongs to the NUT family.
Protein: RL4_LEGPA
Sequence: MEITTIDTKSKLKLNKEIFAYTYNEGLVHQAVVTFMNNARSGNSAQKTRSEVSGGGKKPWNQKGTGRARAGTIRSPLWRSGGVTFASKKRDYSQKLNKKMYKRALRSIISELCRTGNLMVVSDFQCDNHKTKDFLKKMNQMEISNALIIMSEVGENEYLGSRNLIDYDICDVTTIDPVSLLRFEKVVVTEAAIKKIEEQLQ
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NDEL1_MOUSE
Sequence: MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENSFPSPKAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYVPGSVNCGVMNSNGPECPRSGRATFFHKGAVNGFDPAPPPPGLGSSRPSSAPGMLPLSV
What is the function of this protein?
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome.  May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome.  Also positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends.  Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome.  Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate.  Plays a role, together with DISC1, in the regulation of neurite outgrowth.  Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1.  Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.  Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970).
What are the official names of this protein?
Nuclear distribution protein nudE-like 1, Protein mNudE-like, Protein Nudel, mNudE-L.
What is the protein family that this protein belongs to?
Belongs to the nudE family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the kinetochore in a CENPF-dependent manner. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Localizes to the interphase centrosome and the mitotic spindle.
Protein: ISCS_GLAP5
Sequence: MKLPIYLDYAATTPVDERVAKKMMEYMTKDGVFGNPASRSHKFGWEAEEAVDVARNQIADLIGADAREIVFTSGATESDNLAIKGAAHFYQTKGKHIITVKTEHKAVLDTCRQLEREGFEVTYLEPETTGLVDIAKLEAAIRPDTILVSVMQVNNEIGVIQPIEEIGKICRAKKIIFHVDATQSVGKIPVDVQALNVDLMSFSSHKLYGPKGIGGLYVCRKPRVRLEAIIHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMVTEMPRIKALRDRLYNGFKDMEEVYVNGTMEAGKRVDSNLNISFNFVEGESMMMSLKDIAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSIGRWTTEEEIDHTIEIVKKAVTKLRELSPLWDMFKEGIDLNSIEWSHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_MYCLB
Sequence: MATTWPPCRIIRKSGGLRGMWTLEYELQRSGLGPVAGVDEVGRGACAGPLVVAACVLGPGRLEESLDDSKKLSAKGREMLFPLICRYALAYHVVFIPSVEVDRHGVQVANIEGMRRAVAGLSVRPGYVLSDGFRVPGLSVPSLPVVGGDAVVACIAAASVLAKVSRDRLMVAMDADYPGYGFAAHKGYCTRAHSLALTQLGPCPEHRYSFINVRRIVTRSNTRAVAGFTPAPPAEHGECR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CIAO1_ASPFC
Sequence: MVMAAEASSQLSLLSDLTPPSLERTWLTAPHPTLPIVATCSSDKTVRVYSLTNFRLLSTISGGHKRSVRTCAWKPHVKGESVLATGSFDATVGIWRRWDSYGQTERGIEDWRHADSHDHVDGMGAAGINNGGGDSADEDDEEWRFAVLLDGHDSEVKSVSWSPSGMLLATCSRDKSIWIWEDLDDGDNNFETVAVMQEHQGDVKCVAWHPVEECLASASYDDTIRLWREDLDDWGQVACIKGHQGTVWCVDWEGAENVPSAPTDLADDDPVTAQWKKAHALSGPRLVSCSDDRTVRIWRRQPKEQHQHQAQPSPSGGSGIPSIIRPTGSDEFWDEECVLPQAHDLSIYTVAWSKRTGLIASVGADGRVVVYEERFIVGSTAEAMETDHPTSADGTAADSPAALRTEWRVIATVDGAHGIYEINHVTWAKRADRGRIEGTDEEVLITTADDGTVRVWTLKM
What is the function of this protein?
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for the maturation of extramitochondrial Fe/S proteins.
What are the official names of this protein?
Probable cytosolic iron-sulfur protein assembly protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CIA1 family.
Protein: UP01_ELAGV
Sequence: STEQEDP
What are the official names of this protein?
Unknown protein 1.
Protein: RBFA_VIBVY
Sequence: MSKDFSRTQRVSQQLQKELAMILQREVRDSRLGMVTISDVEVSRDLAYAKVFVTFLCVGEQTPESCLAALREHEVHIRMMLGKRIRLRLTPEVRFYYDNTLVEGMRMSNLVTEVVNKDKIKQKDAGREDEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_SOLBU
Sequence: MVTIRADEISNIIRERIEQYNREVKIVNTGTVLQVGDGIARIHGLDEVMAGELVEFEEGTIGIALNLESNNVGVVLMGDGLLIQEGSSVKATGRIAQIPVSEAYLGRVVNALAKPIDGRGEISASEFRLIESAAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAIGQKASSVAQVVTTLQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYRERHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSSLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNSGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFAQFASDLDKATQNQLARGQRLRELLKQSQSAPLTVEEQIMTIYTGTNGYLDSLEVGQVRKFLVELRTYLKTTKPQFQEIISSTKTFTEEAEALLKEAIQEQMDRFILQEQA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: MRP7_CAEEL
Sequence: MLSSFCGDGHPFSTGLPNVSICAQHTVLVWVPAAFFLLTLPFLSAQCHLTAQRFARLPFSAHFIIKLLLVAFLAANSLATWCYVLFSKNSYAAAYYVYPGLWVLVWTGTFLVHLIRLRCGLVSSGIQHVTSLIFLLCGAPEFYQWIRMENSNSFPNDLTTTDSAQFLSIAYLSWYSALILYTFSLCFADPRGAKTDDEKASSKSAASPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFELNERSGTEFLSELWESFWEPKRLKYIHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLASTLKFVSDTMQFASPFLLHELLNFISAKNAPFWKGMALSILMFSVSELRSLILNGYFYIMFRMGTKIQTSLTAAVYKKTLLISNSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIMVIFVPMNIISSMIVRKWQIEQMKLKDERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELALIKKSAMVRNILDSFNTASPFLVALFSFGTFVLSNPSHLLTPQIAFVSLALFNQLRSPMTMIALLINQAVQAVVSNKRLKEFLVAEELDEKCVDRSVNIERSHNAVRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEMGKLRGRIGVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTEIGEKGINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILVTHGLTYTKMADEILVMLEGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAIGGEIQDYMNPEDVVLTVTNDLDETIRTPELTTQISTMSSPEKPPTGTSPAAATESQNKLIKKEGIAQGKVEIATYQLYVKAAGYLLSIAFIGFFIVYMTLQILRSFWLSAWSDEYDPDSPSAHPMAKGWRLGVYGALGFSETACFFVALLALVFVGQRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNRCAKDIETIDMMLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLALIYLIFLRYYVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSLVSNRWLAVRLEFVGNCIIFFAALFAVLSKEFGWITSPGVIGVSVSYALNITEVLNFAVRQVSEIEANIVSVERVNEYTNTPNEAPWRIEGREPAPGWPSRGVVKFDGYSTRYREGLDLVLHDISADVAAGEKIGIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVLFSGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARALLRHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFDTPDALMADKNSAFAKMVADAAEQDKHE
What is the function of this protein?
Negatively regulates cellular toxicity by mediating the export of environmental toxicants such as methylmercury out of the cell (PubMed:24266639).  Plays a role in inhibiting methylmercury-induced dopamine (DA) motor neuron degeneration (PubMed:24266639).  Not involved in Mn(2+)- or Al(3+)-associated toxicity (PubMed:24266639).
What are the official names of this protein?
Multidrug resistance protein mrp-7.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KBAZ_ECOL6
Sequence: MKHLTEMVRQHKAGKTNGIYAVCSAHPLVLEAAIRYASANQTPLLIEATSNQVDQFGGYTGMTPADFRGFVCQLADSLNFPQDALILGGDHLGPNRWQNLPAAQAMANADDLIKSYVAAGFKKIHLDCSMSCQDDPIPLTDDIVAERAARLAKVAEETCLEHFGEADLEYVIGTEVPVPGGAHETLSELAVTTPDAARATLEAHRHAFEKQGLNAIWPRIIALVVQPGVEFDHTNVIDYQPAKATXLSQMXENYETLIFEAHSTDYQTPQSLRQLVIDHFAILKVGPALTFALREALFSLAAIEEELVPAKACSGLRQVLENVMLDRPEYWQSHYHGDGNARRLARGYSYSDRVRYYWPDSQIDDAFAHLVRNLADSPIPLPLISQYLPLQYVKVRSGELQPTPRELIINHIQDILAQYHTACEGQ
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of KbaY.  When expressed alone, KbaZ does not show any aldolase activity.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. KbaZ subfamily.
Protein: DCTN2_RAT
Sequence: MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELSSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSSKGSSGGKSTGGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMETVELLQAKVNALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRENLATVEGNFASIDARMKKLGK
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.  In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity).  Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.  Involved in anchoring microtubules to centrosomes.  May play a role in synapse formation during brain development (By similarity).
What are the official names of this protein?
Dynactin subunit 2.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunit 2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
Protein: CLC4M_PANTR
Sequence: MSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGPLVLQLLSFTLLAGVLVAILVQVSKVPSSLSQEQSEQDTIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTQLKAAVGELPEKSKLQETYQELTQLKAAVGELPEKSKLQEIYQELTQLKAAVGELPEKSELQEIYQELTQLKAALGKLPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQRNWHNSVTACREVRAQLVVIKSAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEPNNSGNEDCAEFSGSGWNDNRCDIDNYWICKKPAVCFRDE
What is the function of this protein?
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver.  May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments.  Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.  Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity).
What are the official names of this protein?
C-type lectin domain family 4 member M, CD209 antigen-like protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: Y2974_BORA1
Sequence: MSIPDTEIPVDDDGYDENGYDRPSKSQVKREMHALLDLGKQLIELSPERLRQLPLEERLYEAIRTAQRTTGREGRRRQIHFVGKLMRAAPADDIRRQLDVWENGSREETAAMHRLEGLRERLIADDEALTELLSRYPGADVQHLRAVIRAARKEAQQNAALLQGQEPQRKQYRALFQALKSLTQ
What are the official names of this protein?
UPF0307 protein BAV2974.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: CD20_MOUSE
Sequence: MSGPFPAEPTKGPLAMQPAPKVNLKRTSSLVGPTQSFFMRESKALGAVQIMNGLFHITLGGLLMIPTGVFAPICLSVWYPLWGGIMYIISGSLLAAAAEKTSRKSLVKAKVIMSSLSLFAAISGIILSIMDILNMTLSHFLKMRRLELIQTSKPYVDIYDCEPSNSSEKNSPSTQYCNSIQSVFLGILSAMLISAFFQKLVTAGIVENEWKRMCTRSKSNVVLLSAGEKNEQTIKMKEEIIELSGVSSQPKNEEEIEIIPVQEEEEEEAEINFPAPPQEQESLPVENEIAP
What is the function of this protein?
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes.  Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
What are the official names of this protein?
B-lymphocyte antigen CD20, B-cell differentiation antigen Ly-44, Lymphocyte antigen 44, Membrane-spanning 4-domains subfamily A member 1.
What is the protein family that this protein belongs to?
Belongs to the MS4A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor. Note=Constitutively associated with membrane rafts.
Protein: VEGFA_CAVPO
Sequence: APMAEGEQKPREEVKFMDVYKRSYCRPIEMLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDESLECVPTEEFNITMQIMRIKPHQGQHIGEMSFLQHSKCECRPKKEKARQENPCGPCSERRKHLFVQDPQTCKCSCRNTDSRCKARQLELNERTCRCDKPRR
What is the function of this protein?
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.  Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.  Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).  Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
What are the official names of this protein?
Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Protein: RL24_GEOSW
Sequence: MHVKKGDKVQVISGKDKGKQGVILAAFPKKNRVIVEGVNIVKKHAKPSQANPQGGIITKEAPIHVSKVMPLDPKTGLPTRIGYKIVDGKKVRYAKRSGEILDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CRCB2_STAAW
Sequence: MISIILVMIGGGFGAITRSAITDYFNHKFTSKLPIATLIVNLVGSFLIGLNIGLSISISWFPAFFVTGFLGGLTTFSTLAKELTLMMTPKFNINLFLNYSLLQFIIGFIACYIGYHI
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARF6_RAT
Sequence: MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
What is the function of this protein?
GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:26446845).  Required for normal completion of mitotic cytokinesis.  Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:16672654).  Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization.  Regulates surface levels of adherens junction proteins such as CDH1.  Required for NTRK1 sorting to the recycling pathway from early endosomes (PubMed:26446845).
What are the official names of this protein?
ADP-ribosylation factor 6.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, ruffle. Cleavage furrow. Midbody, Midbody ring. Early endosome membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body (By similarity). Recruitment to the midbody ring requires both activation by PSD/EFA6A and interaction with KIF23/MKLP1 (By similarity). After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles (By similarity). Myristoylation is required for proper localization to membranes: myristoylation on Lys-3 allows ARF6 to remain on membranes during the GTPase cycle (By similarity).
Protein: HFQ_PROMH
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNTGTNQAGTNYSGGNATQQDDVAE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: MTX3_HUMAN
Sequence: MAAPLELSCWGGGWGLPSVHSESLVVMAYAKFSGAPLKVNVIDNTWRGSRGDVPILTTEDDMVSQPAKILNFLRKQKYNADYELSAKQGADTLAYIALLEEKLLPAVLHTFWVESDNYFTVTKPWFASQIPFPLSLILPGRMSKGALNRILLTRGQPPLYHLREVEAQIYRDAKECLNLLSNRLGTSQFFFGDTPSTLDAYVFGFLAPLYKVRFPKVQLQEHLKQLSNLCRFCDDILSSYFRLSLGGISPAGQETVDANLQKLTQLVNKESNLIEKMDDNLRQSPQLPPRKLPTLKLTPAEEENNSFQRLSP
What is the function of this protein?
Could function in transport of proteins into the mitochondrion.
What are the official names of this protein?
Metaxin-3.
What is the protein family that this protein belongs to?
Belongs to the metaxin family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion outer membrane.
Protein: BAMB_BURPS
Sequence: MNLLKRYAAPVACAAAVLVFAACSSTKDARRVPTPLTEFKPVLDVQQVWTASVGKGGRYSFSPVAVGDAVYVAGANGSVEKIDAKTGQQVWRTKIGSDLSAGVGSDGNLTAVGALKGGVFVLGPDGKQLWKATVQGEIFSPPLVGNGLVIVRTIDGQVIAFAAQTGEQKWTYRNRAVPLNLRVSAGMTFAGDAAVLAGFPGGGLVALNLQTGEPFWQTPVSFPKGVTEVERINDVTGAPTLVGAETCAVTFQGQLGCFDANSGRPLWEKPFSSRSGVAQDDTVVVGGDDWSVVSAYDVATGKALWRNDKLKSRDVGVPYLLGRAVVLGDYKGFVHFLSRDDGTFVARMKTDGSAIAAAPVLAGNTLVVLTQDGGVYGFRPR
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamB.
What is the protein family that this protein belongs to?
Belongs to the BamB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.