PharMolix/UniProtQA huggingface dataset:
Protein: MOAC_VIBVY
Sequence: MSQFTHINASGEANMVDVSAKAETVREARAEAFVHMAPETLQLIVSGQHHKGDVFATARIAGIQAAKKTWDLIPLCHPLLLSKVEVQLEAIEAENKVRIESVCKLAGKTGVEMEALTAASVAALTIYDMCKAVQKDMVIGPVRLLEKTGGKSGHFKVEA
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: Y041_CHLTR
Sequence: MKKLNLLVLLGVFCGVSGVGDADVKVSDALLQSILVEPKIRVLLLSESTTALIEAKGAFSVFGDGELLRVSSQGQRCAAHALYGGIRWGENYPNVECLKIEPLDGAASLFVNGIQYRGAIYIHRTDRSCLFIVNELAVEDYLKSTLSVKYLKELDKEALSACVILERTALYERLLAGNSHSFWHVNAQEDRYGGFGVTSQFYGVEEAVDWTSRLVLDNPEGLVFNADYLLRANVDRLAIEGYNARQILEKFYKDADLVVIESWEDDCKGA
What are the official names of this protein?
Uncharacterized protein CT_041.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0389/CT_041/TC_0311 family.
Protein: CHMA_BPDPK
Sequence: MAVNENEIGTVQTQATAPAPQPTAQRQAQRPTGAPGSTTGINHLMRRSGRLDGSDARSADALQVFTKVKEEAIRHQDLPDDFDIHRFDRDAQQVGMAGLLIVKLAKDINGSMKAFVRTLVLDNLPGTRIRPRTHKINNGLTDDIIEEKVLPRDVFTAQYWSKIGEFLRNRYNIPGLEVLSAGPRAVYADFDFKDELAVKNLLVESVNICEDAIARRNNETPFSIATHIKAENEQLTCNLDYNGIPVKDSCGNPIRSDMVISTSRGKKTNVPENEFYDTDSQLNQVSLFVDLHWTPTTGQQQGMFGVTLPGAALPPQFTPYIVITDVRKASWIQAWTLEMWLFALGNAYRATASQAWARTLMPKIATSKMRDIGALGYYSELGKAIETRTEAFMADDSNFVMLMNKMVNQNPAFQIDIDPMGDNSAIEQVILDAAGGVNQARAVSLIFQALTNLYGTDFRQFYNLAEAGPIIFDNHHEVDLGHYTDEHGELSDRRDLDVLGAMNMSEGNDQEWKTWYATQVGNDHIVRRMNNSKGFDKMYLGNVTYTGRARRLTFNPKFITAMDAAAAAAGVTVTMENLITNFGQQRFAGYTGMGNMAVSGSAQVGMAGSMGQTYGAPSYNAPGTWY
What is the function of this protein?
Self-assembles to forms a proteinaceous shell that encloses the viral DNA and compartmentalizes proteins and DNA during viral infection (PubMed:28813669).  This micrometer-scale compartment contains narrow pores and is the site of viral replication, with the proteins involved in DNA replication localized inside (PubMed:28813669).  Provides a surface for docking of capsids during packaging (PubMed:28813669).  Probably protects the viral genome against host defenses (PubMed:28813669).
What are the official names of this protein?
Chimallin, ChmA, Phage nucleus enclosure protein, PhuN, gene product 54, gp54.
What is the protein family that this protein belongs to?
Belongs to the Phikzvirus chimallin family.
Protein: DNAK_CHLTE
Sequence: MGKIIGIDLGTTNSCVAVMQGTQPTVIENSEGSRTTPSMVAFTKTGERLVGQAAKRQAVTNPKNTIFSIKRFMGRKYDEVPNEKKLASYDVVNEGGYAKVKIGDKTYSPQEISAMILQKMKQTAEDFLGEKVTEAVITVPAYFNDAQRQATKDAGKIAGLEVKRIINEPTAAALAYGLDKKKENEKVAVFDLGGGTFDISILELGGGVFEVKSTDGDTHLGGDDFDQVIINYLADEFKKQEGIDLRKDAIALQRLKEAAEKAKIELSSRTDTEINLPFITATQEGPKHLVINLTRAKFEAMSAALFDKLFEPCRRAIKNSKFDIKEIDEVVLVGGSTRIPKVQALVKEFFGKEPNKSVNPDEVVAIGAAIQGGVLQGDVTDVLLLDVTPLSLGIETLGGVMTKLIEANTTIPTRKQEIFSTAADNQTSVEVHVLQGERPMASDNKTLGRFHLSDIPPAPRGVPQIEVTFDIDANGILNVSAKDKATGKEQSIKIEASGKLTEAEIEKMKEDAKAHAAEDQKRKEEIELKNSADSLIFSTEKQLTELGDKLPADKKAAIESALEKLKEAHKSGRVDAIKPAMDELSKVWSDAASNLYGQPGAEPQPETNGHAGGSKGGDGAVNAEYEVIDGDDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CSF3R_HUMAN
Sequence: MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWPSVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLYGQLLGSPTSPGPGHYLRCDSTQPLLAGLTPSPKSYENLWFQASPLGTLVTPAPSQEDDCVFGPLLNFPLLQGIRVHGMEALGSF
What is the function of this protein?
Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation.  Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage.  In addition it may function in some adhesion or recognition events at the cell surface.
What are the official names of this protein?
Granulocyte colony-stimulating factor receptor, G-CSF receptor, G-CSF-R.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 2 subfamily.
What are the subcellular locations of this protein?
[Isoform 2]: Secreted. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Protein: SBMC_ENT38
Sequence: MDYSIKQQQKRKIAGFHMVGPWEQTVKQGFEQLMMWVDGHHIQPLEWVAVYYDNPDEVPAEKLRCDTVVTVPDDFVIPANSEGVILTEVAAGDYAIATARVENYDFGTPWHSFFNSLLQDNHYQIAPKPCFERYLNDGNADGYWDIEMFVPVQNKAG
What is the function of this protein?
Inhibits the supercoiling activity of DNA gyrase.  Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase.  It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
What are the official names of this protein?
DNA gyrase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFB_SHESR
Sequence: MSTMLIAVILLTLLALFFGVLLGFAALKFKVEGNPIVDELEAILPQTQCGQCGYPGCRPYAEAIANGDKVNKCPPGGTATMEKLASLMGVEPEPLNAEAQSQVKKVAYIREDECIGCTKCIQACPVDAIIGAGKLMHTVLTADCTGCDLCVEPCPVDCIDMIPVGQNLKNWNWRLNAIPVTLIQETPHEEKRG
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: URE3_BACSB
Sequence: MKLTSREMEKLMIVVAADLARRRKERGLKLNYPEAVAMITYEVLEGARDGKTVAQLMQYGATILTKEDVMEGVAEMIPDIQIEATFPDGTKLVTVHDPIR
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_IDILO
Sequence: MKRVLLFLATNMAILLVVSVVFNIVMAVTGIDAQGSVGLLVFCALFGFGGAFVSLWISRWMAIRSTGARVIEKPQNQSEEWLFRTVQQQAQKAGVPMPQVAVYQSPEPNAFATGRSKNASLVAVSTGLLQSMNADEVEAVLAHEMSHIANGDMVTLTLIQGVINTFVMFFARIIASAIMRGGDNQRGGGFAYYGVVMLLEIVFGVLASTIVMWFSRQREFRADAGSADLVGKQKMIAALRRLQQGKESELDGTMLAFGIKGKRSTMSKLFMSHPPLEERIHALEQRR
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MEOX1_PANTR
Sequence: MDPAASSCMRSLQPPAPVWGCLRNPHSEGNGASGLPHYPPTPFSFHXXPDFPATATAAYPDFSASCLAATPHSLPQEEHIFTEQHPAFPQSPNWHFPVSXARRRPNSGPAGGSKEMGTSSLGLVDTTGGPGEDYGVLGSTANXXEKKSSRRRKESSDNQENRGKPEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWFQNRRMKWKRVKGGQPVSPNGQDPEDGDSTASPSSE
What is the function of this protein?
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development.  Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints.  Binds specifically to the promoter of target genes and regulates their expression.  Activates expression of NKX3-2 in the sclerotome.  Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation.  While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner.  Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
What are the official names of this protein?
Homeobox protein MOX-1, Mesenchyme homeobox 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes predominantly in the nucleus.
Protein: SRR1_CANAL
Sequence: MISMNPIMIRNNLSRSSSPAAPPTTNHSSTVDYFSIKPKLSLDINSQSDSNSTQSNNNEDTHSEQSDYNSYTHNQYYDSDDDEDDFDIRDQLLDPFDKITLSNCNEEYYSPLTPFDGQTTSPQDSIISSKSSNKSTTVVPSPQFQLTLPKLTTYSFLIVDDNIINLKILNRILLKLFPKCHIVQIQDSKLVKDLLHKQSFDSIFIDIEMPDVNGIDIAQFVRQDTKFDNMGMVAVTTRNSTQDLELFKQCGIDFTFHKPLNYSLDFMANSIDDIIITRKNKI
What is the function of this protein?
Required for stress adaptation, morphogenesis and virulence.
What are the official names of this protein?
Stress response regulator protein 1.
Protein: RHAD_KLEP7
Sequence: MQTIIDAWFVQGMIKATSDAWLKGWDERNGGNLTLRLDEADIEPYAADFHAKPRYIALSQPMPTLANQPFIVTGSGKFFRNVQLDPAANLGVVKVDSDGAGYHILWGLTEDAVPTSELPAHFLSHSERIKLTGGKDRVIMHCHATNLIALTYVLENHSDLFTRKLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAETMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAEVLVKVLSMGGMKQTITRDELIALGKRFNVQPLQSALDLYP
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUAG_STIAU
Sequence: MKTGLTVLIAGGGIGGLTLGVALRRAGIAFKIFERAPALLRVGAGISMQSNAMLAFRTLGVDTAVAAAGQEIQGGAILNPRGEEISSMPVSKASAEVGAPMITIHRGRLQDVLHQIVGDDNLVLGAKVEGFRDGPDGLFVRLADGREFQGDLLVGADGLRSAVRAQLLKEPSPRYSGYTSWRGVCDVSEGVRRDYTSESWGPGMRFGVVPIGEGQTYWFATATAPEGGVDHPDARTELLQRFSGWHAPIPQLIENTPSSAIMRTDIHDRVPIRQWVQGRAVLLGDAAHPMTPNMGQGGCQAVEDAVVLARCLSLEAELPAALARYQAVRVERANDFVAGSYRIGQIGQWENAFACWVREKLMRMMSSDRVDARTRRNLQFTPL
What is the function of this protein?
Catalyzes the initial step in the conversion of aurachin C to aurachin B.  Catalyzes the epoxidation of the C(2)-C(3) double bond of aurachin C, which is followed by a semipinacol rearrangement, causing migration of the farnesyl group from C(3) to C(4).  Accepts both NADH and NADPH, but has a preference for NADH.
What are the official names of this protein?
Aurachin C monooxygenase/isomerase.
Protein: PDI11_ARATH
Sequence: MAMRGFTLFSILVLSLCASSIRSEETETKEFVLTLDHTNFTDTINKHDFIVVEFYAPWCGHCKQLAPEYEKAASALSSNVPPVVLAKIDASEETNREFATQYEVQGFPTIKIFRNGGKAVQEYNGPREAEGIVTYLKKQSGPASAEIKSADDASEVVSDKKVVVVGIFPKLSGSEFDSFMAIAEKLRSELDFAHTSDAKLLPRGESSVTGPVVRLFKPFDEQFVDSKDFDGEALEKFVKESSIPLITVFDKDPNNHPYVIKFFESTNTKAMLFINFTGEGAESLKSKYREVATSNKGQGLSFLLGDAENSQGAFQYFGLEESQVPLIIIQTADDKKYLKTNVEVDQIESWVKDFKDGKIAPHKKSQPIPAENNEPVKVVVSDSLDDIVLNSGKNVLLEFYAPWCGHCQKLAPILDEVAVSYQSDSSVVIAKLDATANDFPKDTFDVKGFPTIYFKSASGNVVVYEGDRTKEDFISFVDKNKDTVGEPKKEEETTEEVKDEL
What is the function of this protein?
Protein disulfide isomerase that associates with RD21A protease for trafficking from the ER through the Golgi to lytic and protein storage vacuoles of endothelial cells in developing seeds.  Regulates the timing of programmed cell death (PCD) of the endothelial cells by chaperoning and inhibiting cysteine proteases during their trafficking to vacuoles.
What are the official names of this protein?
Protein disulfide isomerase-like 1-1, AtPDIL1-1, Protein disulfide-isomerase 1, PDI 1, Protein disulfide-isomerase 5, AtPDI5.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Vacuole. Note=Found in protein storage vacuoles and lytic vacuoles in endothelial cells of developing seeds.
Protein: BEXA_HAEIF
Sequence: MIRVNNVCKKYHTNSGWKTVLKNINFELQKGEKIGILGRNGAGKSTLIRLMSGVEPPTSGTIERSMSISWPLAFSGAFQGSLTGMDNLRFICRLYDVDPDYVTRFTKEFSELGDYLYEPVKKYSSGMKARLAFALSLSVEFDCYLIDEVIAVGDSRFAEKCKYELFEKRKDRSIILVSHSPSAMKSYCDNAVVLENGIMHHFEDMDKAYQYYNETQK
What is the function of this protein?
Putative ATP-binding protein, and an energy-coupling component of capsule polysaccharide export apparatus.
What are the official names of this protein?
ATP-binding protein BexA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UBP46_MOUSE
Sequence: MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE
What is the function of this protein?
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action.  May act by mediating the deubiquitination of GAD1/GAD67 (PubMed:19465912).  Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.  Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP12/USP46 subfamily.
Protein: MNMG_CAMJR
Sequence: MFDVIVIGGGHAGVEASAAAARMGKKTLLLTTLIEQIGAASCNPAIGGLAKGHLVKELDAMGGLMGEITDEAGIQFRILNESKGVAVQGSRAQIDMDKYRIIARNKLLKLPNLEISQEQASVLIVENDEVKGVKTNLENIYFAKKVILTTGTFLNGLIHVGENKLQAGRVGELASVNLGNYLQTLGLKMGRLKTGTCPRVDAKSIDFSVLEIQDGDVNPKAFSFRSRNFNPTQLPCYIARTNTTTHEIIKNNFYRAPLFTGQIEGVGPRYCPSIEDKINRFSDKESHHLFIEPQTIDATEYYINGFSTSLPYEVQTQMLRSVKGFENAKITRFGYAIEYDYIEPTELKHTLELKKIKNLYCAGQINGTTGYEEAAAQGFMAGINASLSIDMKEPLILRRDEAYIGVLIDDLVVKGTKEPYRMFTSRAEFRLLLREENAILRLGKYGYDLGLLSEQDFTYIQNIANNLQKGLEFLLSKEFTPNNQNNAFLESLGEDKISSIVNLQKIVARASFDIEKLKKLDPIFETMDHYSLREILNEAKYYHYISMQKAQVEKMKNLSELKIPENFDFKSVSGLSNEVVEKLNHHKPPTIFAASQISGITPAALDILQIYIKMQKKKV
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIRF_HYPVG
Sequence: SLNTTVSFPNSPAFNASTERWTIADPPTYIAAIRPGTEEDIGKVINLARTKRFPFLTRGAGHGYSASLGAFQHGLSLDLSQWKTLKIDKKAQTLTVGPGVTFAEIFDPLFKAGFYIQTGSCSCPSMIGVTIGGGIGRLMGKYGLLMDALQSVRMVGAGGKVMRVSATSHPDLWWGILGAGANFGVITSATYKVHPLVNNGNVFIADFYLPVERSREYFDIVEANYSNMSANLAQIMVASWNRTTSSVQLGGNWVYYGPEKEARKELAPVFNLNATSSTRIVRWSEIISSAGFDEFICQPNQPRSLFSLNQKIYSADGYQAGFEKIEKYFYDHPGGRDTTLVFENFPNQAVAAIPDASTAFPWRDFKGFIQINFAWTAGDDATAQASNKLGKELRNQFATTSGYSEKAIFVNYAHGDESIENIYGRRKLPRLAQLKKKYDPSNLFAYNHPLP
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of virensols and trichoxide, fungal natural products that contain or are derived from a salicylaldehyde core (PubMed:31790246).  The pathway begins with the synthesis of the reduced chain in virensol C by the highly reducing polyketide synthase virA via condensation of one acetate and 8 malonate units (PubMed:31790246).  VirA has interesting programming rules since the first 2 ketides are fully reduced, the 3 following ketides undergo beta-dehydration, and the last 3 ketides are only reduced to beta-hydroxys to yield the trihydroxy portion (PubMed:31790246).  The production of aldehyde virensol C by virA alone is surprising, since virA does not contain a reductase (R) domain that is typically associated with reductive product release in HRPKS (PubMed:31790246).  The cupin-domain enzyme virC is involved in enhancing virA product turnover (PubMed:31790246).  The short-chain dehydrogenase virB then oxidizes the C-7 alcohol of virensol C to a ketone, yielding virensol D (PubMed:31790246).  Virensol D is further transformed to salicylaldehyde 5-deoxyaurocitrin by the short-chain dehydrogenase virD (PubMed:31790246).  VirD catalyzes the dehydrogenation of C-3 to form the beta-ketone aldehyde, which is followed by the generation of the nucleophilic C-2 that is required for the intramolecular aldol condensation between C-2 and C-7, itself followed by dehydration and aromatization which leads to salicylaldehyde 5-deoxyaurocitrin (PubMed:31790246).  While the dehydrogenation of virensol D is definitely catalyzed by virD, the aldol condensation and dehydration may be uncatalyzed or assisted by virD (PubMed:31790246).  The short chain dehydrogenase virG then converts salicylaldehyde 5-deoxyaurocitrin into virensol B which is further hydroxylated by the cytochrome P450 monooxygenase virE to yield the hydroquinone virensol A (PubMed:31790246).  VirI then may oxidize virensol A to form the quinone, while virH performs the epoxidation (PubMed:31790246).  Finally, the two remaining short-chain dehydrogenases, virK and virL, are probably responsible for reducing the ketones to the corresponding alcohols to furnish the epoxycyclohexanol structure in trichoxide (PubMed:31790246).
What are the official names of this protein?
FAD-linked oxidoreductase virF, Trichoxide biosynthesis protein virF, Virensol biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: RSMG_MESH7
Sequence: MYKRLVQEFFPKLDFENLEKYVNLIEFSNKNFNLTAFSGDILWKEGIFESIFTMNFIVGLVNNKENKKLKILDIGAGSGFPSIPFLITNPEIELTISESMQKRCQFLKDISEKLDLKFNLICKPVQEIDPQKFDIITARAVANLEKLEKITKKIHFPKTLLAFIKGPKVFNEVQNCKNCNYKIIKVNNNINKKIFIAFKQVS
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNC_ALCBS
Sequence: MINAIITDIEGTTSSIAFVKEVLFPYAAKRFPDFLADHWDHPCVQEQIKAAEKESGETLGSADKAAALFLRWIEEDRKATPLKTLQGMIWKAGYENGDYTAHMYPDTAPALKKWHQKGIALYVYSSGSITAQKLFFGYSDAGDLTGLLSGYFDTTTGPKQETDSYRKIQQAIDKPANTLLFLSDIEAELDAAAEAGFNTCLLDRQQAGLESRHPVASNFNHINLAD
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: ATG16_MAGO7
Sequence: MSSLPDWRDEYLASIKEAEKNSPVNRDLVEACSQLQDRVAALEAERDALKASGASAGQSASDPASQSGDAAQSAVVARLRLDLAEALGTQERLQSRLGLAESELERLRAKTAEDAKTIRTLNTQCVSLSTKVKDRNEELQGKSKLVENVQDELIALTLQLNVMEQQKAKIQAENDQLVERWMKRMGQEAEAMNLANEPKFAKRG
What is the function of this protein?
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy.  The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS).  Recruits also ATG3 to the PAS.  Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
What are the official names of this protein?
Autophagy protein 16.
What is the protein family that this protein belongs to?
Belongs to the ATG16 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: CHI1_COCP7
Sequence: MRFLIGALLTLQTLVQASSMSSMPNSYPVPEAPAEGGFRSVVYFVNWAIYGRGHNPQDLKADQFTHILYAFANIRPSGEVYLSDTWADTDKHYPGDKWDEPGKNVYGCTKQMYLLKKNNRNLKTLLSIGGWTYSPNFKTPASTEEGRKKFADTSLKLMKDLGFDGIDIDWEYPEDEKQANDFVLLLKACREALDAYSAKHPNGKKFLLTIASPAGPQNYNKLKLAEMDKYLDFWNLMAYDFSGSWDKVSGHMSNVFPSTTKPESTPFSSDKAVKDYIKAGVPANKIVLGMPLYGRAFASTDGIGTSFNGVGGGSWENGVWDYKDMPQQGAQVTELEDIAASYSYDKNKRYLISYDTVKIAGKKAEYITKNGMGGGMWWESSSDKTGNESLVGTVVNGLGGTGKLEQRENELSYPESVYDNLKNGMPS
What are the official names of this protein?
Endochitinase 1, CiX1, Complement-fixation antigen, CF-AG, CF-antigen.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
Protein: MR1AL_DANRE
Sequence: CHSLKYDKLFSNKNTVCYVILVWALTVLAIVPNWFVESLQYDPRVFSCTFAQSVSSLYTIMVVVVHFIVPIGIVTYCYLRIWILVIQVPRRVKPDSRPKIKPHDFRNFLTMFVVFVLFAVCWAPLNFIGLAVAIHPRLGQSIPEWLFTASYF
What is the function of this protein?
High affinity receptor for melatonin.  The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).
What are the official names of this protein?
Melatonin receptor type 1A-like, Mel-1A-R-like, Mel1a receptor-like, Melatonin receptor Mel1a Z1.4, zMel1a-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2168_JANSC
Sequence: MTDETRQGRLILIDGDACPVKEEIYTCAYRHKIPVRLVAASYLRHPDHPLITMVMAGDAFDAADDVIAEAAAPGTLVVTGDILLAERCLEAGSVVLNHKGGAYTANSIGAQVATRAIMADIRAGLDGQGIGGQKPFSKADRSAFSNALETALRRLK
What are the official names of this protein?
UPF0178 protein Jann_2168.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: ULAF_ECOHS
Sequence: MQKLKQQVFEANMDLPRYGLVTFTWGNVSAIDRERGLVVIKPSGVAYETMKADDMVVVDMSGKVVEGEYRPSSDTATHLELYRRYPSLGGIVHTHSTHATAWAQAGLAIPALGTTHADYFFGDIPCTRGLSEEEVQGEYELNTGKVIIETLGNAEPLHTPGIVVYQHGPFAWGKDAHDAVHNAVVMEEVAKMAWIARSINPQLNHIDSFLMNKHFMRKHGPNAYYGQK
What is the function of this protein?
Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 4-epimerase UlaF, L-ascorbate utilization protein F, Phosphoribulose isomerase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. AraD/FucA subfamily.
Protein: LDH_GEOTN
Sequence: MKNGGGNRVAVVGTGFVGSSYAFALMNQGIADEIVLIDANENKAKGDAMDLNHGKVFAPNPTNIWYGDYHDCRDADLVVICAGANQKPGETRLDLVDKNIAIFRSIVESVMASGFQGLFLVATNPVDILTYATWKFSGLPYERVIGSGTILDTARFRFLLGEYFDIAPTNVHAYIIGEHGDTELPVWSQADIGGVPIRKLIESKGEQAREELERIFVNVRDAAYQIIEKKGATYYGIAMGLARVTRAILHNENAILTVSAYLDGLYGERDVYIGVPAVINRHGIREVIELELDDNEQKWFQHSAATLKGVLARSFAQ
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.