PharMolix/UniProtQA huggingface dataset:
Protein: NUOC_CHRVO
Sequence: MASKKMEALGSVVAEALGDKLVRSTLALDELTIVCKASDLLSVAQTLRDHADLAFEQCIDVCGMDYSAYRDEPWDGPRFAAVYHLLSVKLNHRIRLRVFAEDDDFPVIPSVNGIWNAANWFEREAFDLYGIVFEGHPDLRRLLTDYGFVGHPFRKDFPLSGYVEMRYDPTQQRVIYQPVTIEPREITPRIIREENYGG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CB080_HUMAN
Sequence: MERRLIKKEMKKLLGDYIGIRLRENEFDPKGRRQLTFLDDMAHYDLAISVALQWLDPSEDLTWLEWEELKIPLHGRPIYPNRREREAMILSSYAGILMNSIPIEEVFKIYGADSSADSGTIKVPRVSSLCLSLHPFAMLTAPKAAAYARKQSVKSRKVTTNKNATSISAKEANATEWKSSQRFSDTQPKHKVT
What are the official names of this protein?
Uncharacterized protein C2orf80.
Protein: DNAK_CALS8
Sequence: MAHILGIDLGTTNSCMAVIEGGQPVVIPNAEGFRTTPSVVAFTKTGERLVGHAAKRQAITNPERTIISIKRDMGTNRRIKIDDKEYSPEEISAMILMKLKADAEAYLGEKITQAVITVPAYFTDSQRQATKNAGRIAGLEVLRIINEPTAAALAYGLDKEGHQKIMVYDLGGGTFDVSILEIGEGVIEVLATSGNNRLGGDDFDQRIIDYIADEFMKEHGIDLRKDKVALQRLKDAAERAKIELSSALQTTINLPFITADANGPKHIDMVLTRAKFEELIKDLVEKTREPVETALSDAKLTPEQIDKVILVGGSTRIPYVQEFVKKLTGKEPFKGINPDECVAIGAAIQAGVLGGQVKDILLLDVTPLSLGIETLGGVFTKIIERNTTIPTRKSQIFTTAADGQTQVEIHVLQGERPLAKDNKTLGRFILDGIPPAPRGVPQIEVTFDIDANGIVHVSAKDLGTGREQKITITSQTHLSEEEIQRAIKEAEMYAEQDRKRKELIETRNKADSIIYQTEKLLRDLGDKMTATEKEQIEAKLKALKDVMNGEDKERIERAIDELTKSFYDVSTRLYQQGYTQAGPQGGTNPGGQGGTDGNVNTDYKVY
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: BRN_DROME
Sequence: MQSKHRKLLLRCLLVLPLILLVDYCGLLTHLHELNFERHFHYPLNDDTGSGSASSGLDKFAYLRVPSFTAEVPVDQPARLTMLIKSAVGNSRRREAIRRTWGYEGRFSDVHLRRVFLLGTAEDSEKDVAWESREHGDILQAEFTDAYFNNTLKTMLGMRWASDQFNRSEFYLFVDDDYYVSAKNVLKFLGRGRQSHQPELLFAGHVFQTSPLRHKFSKWYVSLEEYPFDRWPPYVTAGAFILSQKALRQLYAASVHLPLFRFDDVYLGIVALKAGISLQHCDDFRFHRPAYKGPDSYSSVIASHEFGDPEEMTRVWNECRSANYA
What is the function of this protein?
Neurogenic protein essential for the development and maintenance of epithelial structure.  Required in the germline for establishing the follicular epithelium and for determining the dorsal-ventral polarity.  Collaborates with Notch on the apical surface of follicle cells to mediate germline-follicle cell adhesion.  Brn has a role in chorion formation.
What are the official names of this protein?
Beta-1,3-galactosyltransferase brn, Brainiac protein, Neurogenic secreted-signaling protein brn.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: KCTD6_HUMAN
Sequence: MDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPMDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD
What is the function of this protein?
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins.  Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization.  Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive.  Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).  Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).
What are the official names of this protein?
BTB/POZ domain-containing protein KCTD6, KCASH3 protein, Potassium channel tetramerization domain-containing protein 6.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with ANK1 isoform Mu17 at the M line in differentiated skeletal muscle cells and heart.
Protein: SYI_AQUAE
Sequence: MEEKKVDLKDTLNLPRTEFPMKANLPQREPQILEKWKGLYEKIQKERKGREVFVLHDGPPYANGHIHVGHALNKILKDVINKYNLLIGKNVNFIPGWDCHGLPIERAVEKELSKKKIKKESLPKTEFRELCREYAKKYVNIQREDFVRLGVLGDWEHPYLTMDPKYEAQEIRELGKFFERGLAYRSKKPVYWCIYDKTAEAEAEVEYYEKEDPSIYVKFPLKSGEKFGIKDKKVFAIIWTTTPWTLPANLGIMVKEDADYVLVEVEDEVWIVAKELMDKFFETVNRPEGLVLETVKGKDLVGLEYTHPFVEKEKLKGHLSEETLKNMWKIYPSEFVSLDTGTGLVHMAPGHGQEDYVVGQRYGLEPYAPVSDEGRFVEPAPEFLINVRVFDANHLIVGVLKEKGFLVHEEKIRHSYPHCWRCKNPVIFRATPQWFIGMDIEFFGKTLRQRALEEIEKVKWIPEYGKNRIKSMVENRPDWCISRQRFWGVPITVFYCENCGEIIKDREVFERVAQLVENSEKGSDVWFELTSSQLLPEGYKCPKCGGDSFTKEEDILDVWFDSGCSHAAVIRPLGFQKADLYLEGSDQHRGWFQASLLESVGSYLEAPYKAVLTHGFIVDEKGRKMSKSLGNVISPQEVVKEFGADILRLWVVSEDYTEDVKLGKNLLKKIADDYRKIRNTLRFIIGNLYDFNPRTNALPFEKLHHFDRWIISELQNLLKKVHENYEKFLFYRVHNHIKNFVITTLSAIYLDVLKDRLYVYAPASWERRSAQTALWHLLIALTTSTAPYLSFTAEELWEHVGKLDPSLPESVFLYEMPKPDENLKDEEVLKDYEILLKVRDEVMRALEVARKEKGIIKHPYEAKVYIRGDESVESLLKKYEDYLNFFFTVSQVELREGGEVQIEGEELPVKVGVNKAEGEKCPRCWIYYQKEEFVGCVCKRCAKALSEMGIELNAVC
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEJE_ECOLI
Sequence: MSRLSPVNQARWARFRHNRRGYWSLWIFLVLFGLSLCSELIANDKPLLVRYDGSWYFPLLKNYSESDFGGPLASQADYQDPWLKQRLENNGWVLWAPIRFGATSINFATNKPFPSPPSRQNWLGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLIILLSSVVQPNFWWLLAITVLFGWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFLPFILCSSITTLTSLDFLGFGLPLGSPSLGELLLQGKNNLQAPWLGITAFLSVAILLSLLIFIGEAVRDAFDPNKAV
What is the function of this protein?
Probably part of a binding-protein-dependent transport system.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Inner membrane ABC transporter permease protein YejE.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COXX_PARXL
Sequence: MDSTTLSQTPGSRVSQYIALTKPRVTQLAVFCAVIGMFLSTPGMVPWTPLIGGTVGIWLLAGAAFAINCLVEQKIDAKMRRTSWRPSARGEITTAQILLFSAVLGGLGMWTLYTFANPLTMWLTLATFVGYAVIYTLLLKPATPQNIVIGGASGAMPPALGWAAVTGHVPGDAWILVLIIFVWTPPHFWALALYRRKDYENAGLPMLPNTHGEKYTRLHILLYTVILFAVTMMPFISGMSGVVYLAAAVLLGALFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARVLIGA
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUR2_LISIN
Sequence: MNLLVVGSGGREHAISKKLLESNNVEKVYCAPGNDGMRLDDIQLVAISETDKVGLIDFAKKADVSFVIVGPEVPLLEGVVDAFEEAGIKAFGPKANAALIEGSKDFAKQFMEKYAIPTAASRTFTDYAEAKAYLDERGVPIVIKADGLAAGKGVTVALEMEEAVLALKDMMLEEKFGDASLKVVIEDFLAGEEFSLMAFVNGEEVYPMAIAQDHKRAYEGDKGPNTGGMGAYSPVPHISEDVVNEAVEKILRPAAKGMVQEDRYFRGILYAGLILTTEGPKVIEFNARFGDPETQVVLPRLESDFAALIAALLNNEKPEVRFKKEGITLGVVLASAGYPEHYEKGNKLTGLNDIREDVAIYHAGTKQNENGEFVSSGGRVLLLAKEAETMSDARTLLYPEMQKLDNPNFFYRMDIGTKAE
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: TRPGD_ECOLI
Sequence: MADILLLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEPANTLQPILEKLYQAQTLSQQESHQLFSAVVRGELKPEQLAAALVSMKIRGEHPNEIAGAATALLENAAPFPRPDYLFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSDLLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPIAETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQEQLAGGTPEENRDILTRLLQGKGDAAHEAAVAANVAMLMRLHGHEDLQANAQTVLEVLRSGSAYDRVTALAARG
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.  In addition to synthesizing anthranilate, it also catalyzes the second step of the pathway, the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate.
What are the official names of this protein?
Bifunctional protein TrpGD.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the anthranilate phosphoribosyltransferase family.
Protein: RDRP_LOLV
Sequence: MTTLALNLAQYNDPITKGIIAQESLRRVRPDLKAVVNVNPYAIPTSAALVLEKLGIGTHPMSLAVHPHAPCKAIENQILNTVGHLLPKEQPVTFMAMKKSKLNMLRRHPSRADTFINPIYHPRDNVRYGLDPDPDQDASITASFLEVKTSTAFMQDTLHYLTPEDLLDIFETSPKLENLIASFVLPVEATRNMKSLYPDLYSIHYTHGGFQWAPSGHLGDAYFHEPWQLYWLRCGSLTRLIEEETTTTVQPPPGFEGEAYTRVRKEVRELKIYAERVTSIGAHHLFIFSRNAKATPRVRSYSQNGKWVTLPRIFRPVSHNVQTPLKQEVANSLMLYTYAVRPSLKDVAAKVRQKFDEKDLAEHSPLEITHLINYIYYIDQRAYLTNDDDILSDNLLKRWIFTPIQAAYKKAKGFLLGPDDFQKLLKALEWQPVTFDYAVDHYKSNPWRIHASRTGAKMRQLKNFLSRTTGLCEAVEDDALEGSELLKELEGNMWFRNPSEVEKEVFDAIVADLPPDSQRSELILEDPNSNARDYLPIQQDQPSVTQGPDEAAQTQTPTATSMVTNSVAARMPPPVPRTLREHHEQFPTTVRASFEQPSSTRAPETSENNTPAESVTPSPRAIYVGDFAIMDANASTSRASSPSPRRTVVSPRQPEAQNETLGRQIVSRVSPAHGCQMSPYAAQLAHQLSEQTAYTDVIGQRMVAFYSQHSRSYKYGRHEHRSQSWLPVIDSLQVALGLDESYDHCLIQRYRKHARVGLHADDEECYEPDSTIVTLNLYGNADFLIERNTDKASETITLQHNDMLFMPSGMQVTHRHAVCSLYEGRVSITFRNKTKDYLRKSAPDMNPVEQPGASAGQLTGPLDHRPEELPWEHWIPRLNRLGFTGLQKQTDPEGKLIYPITEIRQDMVYVPFPNCCPGPLRKDLEAMGRRPVRYTVDTGRALTLASDIKNNRVGALLQNADLTWKTLLVEYCRMEPTSVPMTVIHGAGGSGKSKLLQDHLNRAELNVVIIVPTRVLQQDWRNKMTEFPSFLVQTYEAAMMESAPQMVVFDDYGKLPHGYIDLFCQFHPSVEYVILTGDARQSTYYEYNSDAGIRNLPTNIEVFKQYCGYYINCTHRNKQDLANMLGVYSEKMGSTHFTFGNTCETGSLLLVPSGTQKTVMGEAGHKTETYAGCQGITADKVQIMIDHDTHKSADSHMYTALSRATEHIHFYNSIAGLNTARFHAKLNLTPYLKTFIQVITERAAAETEPAEYTVQAPTARTHIPVENCSTFLEKDLEEQRAKEDREVYTQAGATNVFQTNSPIVQCFQHQQPKDGALSIITHAKRLQYASAEANQAEYRAKLQIGAALWENFKTAMEIPDEPVPFIRDLWEQSEAEVLSTYLSKSEMAIKNGKNRQDPDWQDERMFVYLKAQWVTKASKFNLPTAKAGQTISAFKQAVVMKFGAMARYLRRITPKPDNIRINCEMQPQDISKWALGLDSHNRPTKQKWNFERPAFASDFEAFDQSQDGAMLHFEALWARHFNVPSSLIEEYLFLKMHAQAPKGYLTIMRLTGEGPTFDANTACSIAYNHTRYEIPKSCMQLYAGDDMLLDQVPVEKTGFKNIAAGLKLTAKTEIFEQKRGKWGEFCSWWMTPYGLVKDPITLYHRILLASEIGDLSKKIDAYAIEAEPAYALQGRLFDCFNEEQMTAHYGTIRRLIIEGKTNFSLDDQAPRHQDLQGILNCMDAKFMYH
What is the function of this protein?
RNA replication.  The central part of this protein possibly functions as an ATP-binding helicase (Probable).
What are the official names of this protein?
RNA-directed RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the potexvirus/carlavirus RNA replication protein family.
Protein: ZDS_ARATH
Sequence: MASSVVFAATGSLSVPPLKSRRFYVNSSLDSDVSDMSVNAPKGLFPPEPVPYKGPKLKVAIIGAGLAGMSTAVELLDQGHEVDIYDSRTFIGGKVGSFVDRRGNHIEMGLHVFFGCYNNLFRLMKKVGAEKNLLVKDHTHTFINKDGTIGELDFRFPVGAPIHGIRAFLVTNQLKPYDKLRNSLALALSPVVKALVDPDGAMRDIRNLDSISFSDWFLSKGGTRASIQRMWDPVAYALGFIDCDNMSARCMLTIFSLFATKTEASLLRMLKGSPDVYLSGPIKQYITDRGGRIHLRWGCREILYDKSADGETYVTGLAISKATNKKIVKADVYVAACDVPGIKRLLPKEWRESRFFNDIYELEGVPVVTVQLRYNGWVTELQDIELARQLKRAVGLDNLLYTPDADFSCFADLALASPADYYIEGQGTLLQCVLTPGDPYMRMPNDKIIEKVAMQVTELFPSSRGLEVTWSSVVKIAQSLYREAPGKDPFRPDQKTPIKNFFLAGSYTKQDYIDSMEGATLSGRQASSYICDAGEELAELNKKLSSSATAVPDELSLV
What is the function of this protein?
Plays a crucial role in plant growth and development.  Is essential for the biosynthesis of carotenoids.  Carotenoids are involved in different physiological processes, including coloration, photoprotection, biosynthesis of abscisic acid (ABA) and chloroplast biogenesis (PubMed:17468780, PubMed:24907342).  Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene.  It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'.  Shows stereoselectivity toward trans C15-C15'zeta-carotene double bond.  The zeta-carotene produced by the phytoene desaturase PDS has a C15-C15' double bond in the cis configuration and it requires isomerization before being recognized as substrate by ZDS.  The main product is 7,9,7',9'-tetra-cis-lycopene (pro-lycopene) (PubMed:9914519).
What are the official names of this protein?
Zeta-carotene desaturase, chloroplastic/chromoplastic, 9,9'-di-cis-zeta-carotene desaturase, Carotene 7,8-desaturase, Protein CHLOROPLAST BIOGENESIS 5, Protein PIGMENT DEFECTIVE 181, Protein SPONTANEOUS CELL DEATH 1.
What is the protein family that this protein belongs to?
Belongs to the zeta carotene desaturase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, chromoplast.
Protein: HSLU_ECO55
Sequence: MSEMTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNNWGQTEQQQEPSAARQAFRKKLREGQLDDKEIEIDLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDAMKLLIEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNESTENIGARRLHTVLERLMEEISYDASDLSGQTIIIDADYVSKHLDALVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Heat shock protein HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPP_BURMA
Sequence: MKSSGSARATRRNAVSSSSAPAHAEPPARRAAKPARKLDGAAARPLAPTNAASAKPQGRTREDKDRPLFEDIRYLGRLLGDVVREQEGDAVFDVVETIRQTAVKFRREDDKAAAQTLEKMLRKLTPEQTVSVVRAFSYFSHLANIAEDRHHNRRRRIHALAGSAAQAGTVAYALDKLKQAGDASSKTIKQFFEGALIVPVLTAHPTEVQRKSILDAQHDIARLLAERDQPLTARELAHNEALLRARVTTLWQTRMLRDARLTVADEIENALSYYRATFLDELPALYADIEEALAEHGLRARVPAFFQMGSWIGGDRDGNPNVTAATLDEAISRQAAVIFEHYLEQVHKLGAELSVSNLLVGASDALKALAAASPDQSPHRVDEPYRRALIGVYTRLAASARVRLGEGTVPVRSAGRGAAPVRATPYADAEEFAADLRVLTDSLALHHGESLATPRLAPLMRAAEVFGFHLASIDLRQSSDIHEAVVAELLARGGVEADYAALPEADKLRVLLAALADPRPLRSPYLDYSDLAKSELGVLERAHAIRAQFGARAVRNYIISHTETVSDLVEVLLLQKETGLFEGTLGTPHANARNGLMVIPLFETIADLRNASDIMRAFFALPGVGELLAHQGHEQEVMLGYSDSNKDGGFLTSNWELYRAELALVDLFDERGIKLRLFHGRGGTVGRGGGPTYQAILSQPPGTVNGQIRLTEQGEVIASKFANPEIGRRNLETVVAATLEATLAPHSNAPKQLPAFEAAMQTLSDAAMASYRALVYETPGFTDYFFSSTPITEIAELNIGSRPASRKLQDPKNRKIEDLRAIPWGFSWGQCRLLLTGWYGFGSAVAAYLDGAPDAAERGKRVALLKKMNKTWPFFANLLSNMDMVLAKTDLAVASRYAQLVADKKLRKHVFERIVAEWHRTADALAEITGAHARLAANPLLARSIKNRFPYLDPLNHLQVELIKRHRAGDTNARLRRGIHLTINGIAAGLRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: ACSA_CAMJJ
Sequence: MLNQNNQELFKPSKEFSRNARIKNLCEYYDLCDEAKEDFEGFWKRQAFEKIEWFSPFSRVLNEDKAPFYKWFEGGTLNVSYQCLDRHMKTRRNKAALIFEGEMGDYEVYTYRRLLHETCKAANLLKKFGVKKGDRVVIYMPMIPETAIVMLACARIGAIHSVVFGGFSPEALRDRIIDAGAKLVVTADGAFRRGKPYMLKPAVDKALSEGCESVEKVLIVIRNNEPIEYIKGRDYVYNELVKNESYKCEPEIMDSEDLLFLLYTSGSTGKPKGVMHASAGYILWAQMTMEWVFDIKDYDNYWCSADVGWITGHTYVVYGPLACGATTIMHEGTPTYPNSGRWWRMIEEYQISKFYTSPTAIRMLHADAPNEPRKYDLSTLEVLGTVGEPINPSAWKWFYDEIGGTKSPIVDTWWQTETGGHMITPLPGATPLKPGCATLPLPGIFAEVIDEEGNKKDEGEDGLLCITKPWPSMIRGIWGNDERYIESYFSQAKKDGKAVYFSGDGAFYDKNGYITITGRTDDVVNVAGHRIGTAEIESAIAKHPSVAESAVVSILDTIKGESLFAFVVLSPASSCDLGGAIETLKELNDILRVEIGPIAKIEKILYTPGLPKTRSGKIMRRILRTIARGEEIKQDISTLEDSKVVETIVKLAKAEFE
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: TDH_PYRHO
Sequence: MSEKMVAIMKTKPGYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEIGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNIWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVTIDFNNLIIFKALTIYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate (PubMed:16233775, PubMed:15902509).  Is much less efficient when using NADP(+) instead of NAD(+) (PubMed:16233775).  To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3-phenylserine, but not that of L-allo-threonine, D-threonine and D-allo-threonine and many other L-amino acids (PubMed:15902509).
What are the official names of this protein?
L-threonine 3-dehydrogenase, L-ThrDH, TDH, L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APHA_XENBS
Sequence: MRKVTLVFSAIAFAFSLNGVVQAKVQMPESVSSGVTTVELSQRQAVHWVSVEQIEKSLQDQPPMAIGFDIDDTVLFSSPGFYRGKLKYSPNDNSYLKNPAFWEKMNNEWDEFSMPKQIGIELVQMHLKRGDNIYFITGRTKTKTETVTKYLQEDLHIPADKMNVVIFAGDDPGKNNKISWMKEHKLKLYYGDADADIAAAHELNIRGIRILRASNSSYQPLPKAGRFGEEVVIKSEY
What is the function of this protein?
Dephosphorylates several organic phosphate monoesters.  Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity).
What are the official names of this protein?
Class B acid phosphatase, CBAP.
What is the protein family that this protein belongs to?
Belongs to the class B bacterial acid phosphatase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CED4_CAEBR
Sequence: MLCEIECRALNAAHTMLIQDFEPRDALTYLEGEKIFTEDHSDLISNMPTRLERIANFLRAYRRQASELAPLIDFFEYNNQNHLKDFLDEYLWFATHQPDKLRPVVLVPKFSRQMLDRKLLLGNVPKQMNCFSREFHVDRVIEKLDEMCDLESFFLFLHGRSGSGKSVIASQALSKSDQLIGINYDSVVWLKDSGTTPKATFDLFTDLLLMLKRARVVSDTDDSHNMPDFINRVLSRSEDDLLNFPSVEHVTSVVLKRMIANALIDRPNTLFVLDDVVQEDTIRWAQELRLRCLITTRDVEISNAASPECEFIEVTPLESYECFELLESYGMPVPAIERDEDILHKTIDLTSGNPAALMMIFKSCEPKTFEKMAQLNSKLETRGLSAIECITPYCYKSLSSSLQRCVEVLSDEDRSALAFAVIMPPGIDIPVKIWSCVIPVDICSNEEDQLDDEVADRLKRLSKRGALLSGKRSPVLTYKIDHVIHLFLKHVVDVQTIANGISILEQRLHELGNNNTPTPERHMPSKFRRTSAGDMFPKVEDSVIRPEDYSKFMQIHRTFYDSLKKFTSQ
What is the function of this protein?
Plays a major role in programmed cell death (PCD, apoptosis).  egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation.  Also forms an holoenzyme with processed ced-3 enhancing ced-3 activity.  Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development.  During oogenesis, required for germline apoptosis downstream of ced-9 and upstream of ced-3 but independently of egl-1.  May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway.  Regulates CEP neuron apoptosis in response to high Al(3+) levels.  During male tail morphogenesis, promotes apoptosis of the tail-spike cell.  During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and ced-9 and upstream of ced-3 apoptotic pathway.  Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), and probably upstream of ced-3, regulates temporal cell fate patterning during larval development.  May play a role in resistance to S. typhimurium-mediated infection.
What are the official names of this protein?
Cell death protein 4.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm, perinuclear region. Note=In non cell death induced cells, ced-9 is required for mitochondrial localization. Perinuclear in cell death induced cells.