PharMolix/UniProtQA huggingface dataset:
Protein: TI214_ARATH
Sequence: MMVFQSFILGNLVSLCMKIINSVVVVGLYYGFLTTFSIGPSYLFLLRARVMDEGEEGTEKKVSATTGFIAGQLMMFISIYYAPLHLALGRPHTITVLALPYLLFHFFWNNHKHFFDYGSTTRNEMRNLRIQCVFLNNLIFQLFNHFILPSSMLARLVNIYMFRCNNKMLFVTSSFVGWLIGHILFMKWVGLVLVWIQQNNSIRSNVVIRSNKYKFLVSELRNSMARIFSILLFITCVYYLGRIPSPIFTKKLKGTSETGGTKQDQEVSTEEAPFPSLFSEEGEDLDKIDEMEEIRVNGKDKINKDDEFHVRTYYNYKTVSENLYGNKENSNLEFFKIKKKEDHFLWFEKPFVTLVFDYKRWNRPNRYIKNDKIENIVRNEMSQYFFYTCQSDGKERISFTYPPNLSTFFEMIQKRIPSFTKEKKTFDQVSTYWSLIHEEKRENLKKEFLNRIEALDKEWSVENILEKTTRFCYNEAKKEYLPKIYDPFLHGISRGRIKKLPPFQIITETYRKNNLGGSWINKIHGLLLKINYKKFEQTIEKFNRKSLSIEKKLSFFSEPQQEEKINSEEEIKTFKFLFDIVRTDSNDQTLIKNFMDFPEINKKVPRWSYKLISELEELEGENEENVPMEPGIRSRKAKRVVVFTDKEPHGEIYTNLKDNQNSDQNDEMALIRYSQQSDFRREIIKGSMRSQRRKTVIWEFFQAKVHSPLFFDRIDKLFFFSFDIWGLKKKIIKNFIWKKKIDKKEEEQSKREETRRIEIAETWDSFLFAQIIRGSLLVTQSILRKYIILPLLIIIKNSVRMLLFQFPEWSQDLKDWKREMHVKCTYNGVQLSETEFPRNWLTDGIQIKILFPFYLKPWHKSKFQASQKARLKKTKDKGEKNDFCFLTVWGMETELPFGSAQRKPSFFEPISKELKKRIKKLKKKSFVVLKIFKERAPIFLKVAKETKNWILKNFIFIKGISKRNLIPLFGPREIYELNEPKKDSIISNQMIHELSVQNKSLEWTNSSLSEKKIKNLIDRKKTIRNQIEEISKEKQNLTNSCTKLRYDSKIIESSKKIWQTFKRKNTRLIRKSIFFFKFCIEQMSIAIFLGIINIPRITTQLFFESTKKILDKYIYKNEENGEKKKNTLYFISTIKNLISNKKKMSYDLCSLSQAYVFYKLSQIKVSNFCKLKAVLEYNICITSFFVKNKIKVFFQEHGIFHYELKNKTFLNSEVNQWKNWLRSQYQYNLPQISWARLVTQNWKNKINKDSLVLNPSLTKEDSYEKKKFDNYKKQKFFEADSLLNPKHNVKKDSIYNLFCYKSIHSTEKNFDMSIGIALDNCLVSSFLEKYNIRGMGEIRHRKYLDWRILNFWFTKKVTIEPWVDTKSKKKYINTKVQNYQKIDKITQTDLANKKRNFFDWMGMNEEILNQRITNFEFFFFPEFFLFSSTYKMKPWVIPIKLLLLNFNENINVNKKIIRKKKGFIPSNEKESLRFYNLNKEEKESAGQVELESDKETKRNPEAARLNQEKNIEENFAESTIKKRKNKKQYKSNTEAELDLFLTRYSRFQLRWNCFFNQKILNNVKVYCLLVRLNNPNEIAVSSIERGEMSLDILMIEKNFTFAKLMKKGILIIEPVRLSVQNDGQLIIYRTIGISLVHKNKHKISKRYKKKSYINKKFFEKSITKYQNKTVNKKKNNYDFFVPEKILSPKRRREFRILICFNLKKKNARDTNSRFDKNIQNLTTVLHKKKDLDLDKDKNNLINLKSFLWPNFKLEDLACMNRYWFNTTNGNHFSMIRIRMYTRFPIP
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: Y3355_PSEE4
Sequence: MIDTPLHTGLGLRRGLLPELLEMQAGEVDFLECAPENWIGVGGAFGQKLECLAERFPIACHGLSLSLGGTAPLDEAFLGLTRRFLDRHQVNLYSEHLSYCSDDGHLYDLLPIPFTEEAVHHVSARIRQAQDLLGRRIAVENISYYAAPYQAMSELDFIRAVLDEADCDLLLDVNNVFVNACNHRYEAHAFLAGIPRERVVGMHVAGHYDEAPDLKVDTHGAPVKEDVWALFARACERFGAQPTVLERDFNYPPLAELLAETARIRDLQQRHGGPRHG
What are the official names of this protein?
UPF0276 protein PSEEN3355.
What is the protein family that this protein belongs to?
Belongs to the UPF0276 family.
Protein: FETP_ECO5E
Sequence: MSRTIFCTFLQREAEGQDFQLYPGELGKRIYNEISKEAWAQWQHKQTMLINEKKLNMMNAEHRKLLEQEMVNFLFEGKEVHIEGYTPEDKK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: FTHS_CAMC5
Sequence: MLSDIEITHLAKLDHISKIGAKLGLGEDDMELYGKFKAKIEPRLDGSNSKLILVTATSPTPFGEGKTTMSIGLADALNRLVKKVCLALREPSLGPVFGIKGGAAGGGYSQLAPMEDLNLHFTGDFHAITSANNLISAMIDNSLYQENPLNIDKILWKRCMDMNDRALRFITVGQGGKADGVEREDGFNITAASEIMAILCLATSLADLKERIANIMVAYNDRGEPIYVRDLGCEDAVCILLKDAMKPNLFQTIEHTPTLVHGGPFANIAHGCNSIIATKTALNLADFVITEAGFGSELGAEKFIDIKCRVAGIAPDAVVLVSTIRSLKYNGGADKESITKPNMSALEVGIANLGGHIENLKQKFGLNVVVALNKFGFDEDSEIDFVRDYCAKFGVKMAVCENFVKGGEGALELANFVLEELKKPNDMKFAYETSDDTKSKITKIATEIYGAGEVVFEEAAQKALEKIKKLGLEKLPVCIAKTQYSFSDDAKLLGRAKGFKFSVKDLQIRTGAGFIVAVCGKIMLMPGLPKTPSALNMHIDTKTGEISGLA
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: ATPH_GOSBA
Sequence: MNPLISAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALSIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: P20D1_MOUSE
Sequence: MAELLASLPAWAAVLLLFFATVSGSTGPRSRENRGASRIPSQFSEEERVAIKEALKGAIQIPTVSFSHEESNTTALAEFGEYIRKAFPTVFHSSLVQHEVVAKYSHLFTIQGSDPSLQPYMLMAHIDVVPAPEEGWEVPPFSGLERNGFIYGRGALDNKNSVMAILHALELLLIRNYSPKRSFFIALGHDEEVSGEKGAQKISALLQARGVQLAFLVDEGSFILEGFIPNLEKPVAMISVTEKGALDLMLQVNMTPGHSSAPPKETSIGILSAAVSRLEQTPMPNMFGGGPLKKTMKLLANEFSFPINIVLRNLWLFHPIVSRIMERNPITNALVRTTTALTMFNAGIKVNVIPPLAQATINCRIHPSQTVHEVLELVKNTVADDRVQLHVLRSFEPLPISPSDDQAMGYQLLQETIRSVFPEVDIVVPGICIANTDTRHYANITNGMYRFNPLPLNPQDFSGVHGINEKVSVQNYQNQVKFIFEFIQNADTYKEPVPHLHEL
What is the function of this protein?
Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase.  It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (PubMed:27374330, PubMed:29533650, PubMed:29967167, PubMed:32271712, PubMed:32402239) (Probable).  Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner.  Thereby, this secreted protein may indirectly regulate whole body energy expenditure (PubMed:27374330, PubMed:29967167, PubMed:32271712).  PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (PubMed:32402239).
What are the official names of this protein?
N-fatty-acyl-amino acid synthase/hydrolase PM20D1, Peptidase M20 domain-containing protein 1, PM20D1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
What are the subcellular locations of this protein?
Secreted.
Protein: M2_I34A0
Sequence: MSLLTEVETPTRNGWECRCNDSSDPLIIAASIIGILHLILWILNRLFFKCIYRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: SULA_YERPP
Sequence: MRTQSLKPYHANYHSLTTNDSPTRVDAPTDSGLISEFVYSENQPVVTQLLLPLLQQLSKQSRWLLWLTPQQKLSRSWLKQSGLPINKVVQLRQINPLSTVEAMEKALLTGNYSVVLGWLPELTEDDRIRLRLAAKLGNAYGFVMRPLNDTKVGSGQCATLKIHSYLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: CRVP_CERRY
Sequence: MIVFILLSLAAVLQQSVADVDFQSESPRRTEKQTEIVDMHNSFRRSVNPTARNMLKMEWYPEAADNAERWAYQCIYDHSANYERVIGGIQCGENIYKSSNPRAWSEMIQDWYDEYKNFVYGVGANPPGSMIGHYTQIVWYKSYRIGCAAAYCPSYPYNYFYVCQYCPVGNMEGLTATPYTSGPTCADCPSHCDDGLCTNPCPINNVFTNCDSLLQQSSCEDSYITTNCGASCFCQDKII
What is the function of this protein?
Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction.  May target voltage-gated calcium channels on smooth muscle (By similarity).
What are the official names of this protein?
Cysteine-rich venom protein, CRVP, Cysteine-rich secretory protein, CRISP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: DCAM_HUMAN
Sequence: MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
What is the function of this protein?
Essential for biosynthesis of the polyamines spermidine and spermine.  Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: VL2_HPV60
Sequence: MYARVKRVKRDSVENLYKQCQLGADCPPDVRNKVEGTTLADRLLQIFGSILYLGNLGIGTGKGSGGATGYTPLGTARVPASTPGTVIKPTRPFSVPLDPIGSGIPSQPVGGRLPVDIIDASASSIIPLQEVLPETTIIVGGDSGPGLGASEIDIVSEPRPDVVGVDTQPTVYTSIDNTVATLDITPATPPVKKIILDPISSGSEGAAAITFSDISAADLNVFVDPQGAGDRISFGEEIELGPINQPAQFEIEEPPRTSTPGEGFQRVTTRARELYNRFVQQQPTQNIDFLGRPSRAVQFEFENPAFFNDEVTMQFEQDLQEVAAAPDQDFADVRELGRARFSETSAGTIRVSRLGTKGTMKTRSGLTIGQKVHFYFDISDIPAAETIQLRTLGESSHDFSAVDNITESTYINLTETTNEGLIPDNILEDEFTENFNNAQLIFATIDEGESMIMPTIPPGVALKLFIPEIAASVLNVVHPSSEWTILIPNVPDEIIQPAMAVDVYDDFYLHPHLLRRRKRKRLDFF
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: TCMO_MEDSA
Sequence: MDLLLLEKTLLALFIAATIAVTISKLRGKRFKLPPGPIPVPIFGYWLQVGDDLNHRNLTDYAKRFGEIFLLRMGQRNLVVVSSPELAKEVLHTQCVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWESEAESVVNDVKNNAEASVGGIVIRKRLQLMMYNIMYRIMFDRRFESEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLKGYLKVCKEVKDRRLQLFKDYFVDERKKLESTKSTTSNDGLKCAIDHILDAQKKGEINDDNVLYIVENINVAAIETTLWSIEWGIAELVNHQDIQNKVREEMDRVLGPGHQVTEPDLHKLPYLQAVIKETLRLRMAIPLLVPHMNLHDPKLNGFDIPAESKILVNAWWLPNNPAHWKKPEEFRPERFLEEESHVEANGNDFRYLPFGVGRRSCPGIILALPILGITIGRLVQNVELLPPPGQSKIDTSEKGGQFSLHILKHSTIVAKPRSF
What is the function of this protein?
Catalyzes the first oxidative step of the phenylpropanoid pathway in higher plants by transforming trans-cinnamate into p-coumarate (By similarity).  The compounds formed by this pathway are essential components for lignification, pollination, and defense against ultraviolet light, predators and pathogens (By similarity).
What are the official names of this protein?
Trans-cinnamate 4-monooxygenase, Cinnamic acid 4-hydroxylase, C4H, CA4H, Cytochrome P450 73, Cytochrome P450C4H.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: UPPP_PYRIL
Sequence: MDFLTAIVLGVVQGVSEWLPISSKTQVMFVSQLLLSATPELAYSLGLFLEAASVLAALIYFRLVYLKILRGFLGDAEGRKWLTYVIVTTAATGAVGIPLYMAAKRYLLLGASAGWLMVVLGVAVIFNAVLLQRARSVAGLKTFDDMTLGHMALVGLAQALSVLPGISRSGITTTTLLLLGYRPDEAFKSSFVLVPIAGLGATALAYLSEGGAVATPEVITAMLIGLVVSLVTIKALLEFAKSKHVTLVNIVVGTLAIAGGITRILLSS
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
What are the official names of this protein?
Undecaprenyl-diphosphatase, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROQ_BACAN
Sequence: MKKVLLVNGPNLNRLGVREVNVYGKGTLATLEADMKQEAEAMGVELECFQSNHEGAIIDRIHEAEDIYEGIILNPGAFTHYSYAIRDAIASISIPVIEVHISNIHQRESFRHESVTAAVCAGQIVGFGFYGYKLALFALMEKLREA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: PYRG_CANGA
Sequence: MKYVVVSGGVISGIGKGVLASSTGMLLKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLNDGGETDLDLGNYERYLNVTLTKDHNITTGKIYSHVIAKERKGDYLGKTVQIVPHLTNAIQEWIERVSRIPVDNTGMEPDVCIIELGGTVGDIESAPFVEALRQFQFRVGKENFALIHVSLVPVIHGEQKTKPTQAAIKDLRSLGLVPDMIACRCSETLEKGVIEKIAMFCHVGADQVVNVHDVNSTYHVPLLLLEQKMINYLHQRLQLQEITLSSEDIQRGENLLSKWKSMTGNFDSSMETVKIALVGKYTNLKDSYLSVIKALEHSSMKCRRKLEIMWVEATDLEPETQDTEKAKFHEAWNKVSTADGILVPGGFGSRGTEGMMLASRWARENHIPFLGVCLGLQIATIEFARNVLGVKEGNSAEFFPELDESNQVVVFMPEIDKETMGGSMRLGLRPTYFQQGTEWCAIKKLYGSAESVEERHRHRYEINPNFIERLEEHGLMFVGRDETNKRCEIFEMKDHPFFVATQYHPEYTSKVLDPSKPFLGLVAASSGILDDVIAGKYEFNGDGKSDF
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
What are the official names of this protein?
CTP synthase, CTP synthetase, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: TCL2_ARATH
Sequence: MDNTNRLRHLRSRKQSKFTLGDTAEVNSVKWEFINMTEQEEDLIFRMHRLVGDRWDLIAGRVVGREAKDIERYWIMRNCDHCSHKRRRVHKFYRFSISPP
What is the function of this protein?
MYB-type transcription factor involved in trichome cell specification.  Acts as a negative regulator of trichome patterning and formation.  May function by suppressing the expression of GL3.
What are the official names of this protein?
MYB-like transcription factor TCL2, Protein CAPRICE-like MYB4, Protein TRICHOMELESS 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL18_STAAT
Sequence: MISKIDKNKVRLKRHARVRTNLSGTAEKPRLNVYRSNKHIYAQIIDDNKGVTLAQASSKDSDIATTATKVELATKVGEAIAKKAADKGIKEIVFDRGGYLYHGRVKALAEAARESGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: NUOD_CAMJ8
Sequence: MQIPSKLKPYYENIAFEQEDSKMIINLGPQHPSAHGNLRLILELDGEQVVKARPCIGYMHRGMEKMAENMIYQEFIPTTDRMDYIAASANNYAYCAAVEKLCGLEIPRRAAVIRMILLELNRIASHLLWLATHALDIGAMSVFLYCFREREYVLDLIEKYCGARLTHSSMRIGGVMLDLPENYLEEMLVFCDKFPNDLKDYEDLLDDNRIWRLRTENVGVVTKEQALNWGCTGVMLRGSGIKYDIRKEEPYLLYNEVEFGVPYATQGDSYARYKVYMQEFRESLKILRQCATLYKDTPPEILATHPEYVSASKEQILTQNYSLMQHFVLITQGLKPPKGEVYVPTESPKGELGFFIHSDGTGRPYRLKARTPSYWHCAFFEEMLVGTYLADVVAIMGNVNIVLGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL1_AROAE
Sequence: MTKLSKRVQALRTKVDRNRTYPVTEALALVKECATAKFDESIDIAVNLGIDARKSDQLVRGSVVLPAGTGKSVRVAVFAQGDKAEAARAAGADVVGFEDLAEQVKAGNIDFDLCIATPDAMRVVGQLGQILGPRGLMPNPKVGTVTMDVTTAVKNAKAGQVQYRTDKGGIIHATIGRASFSTEALQQNLGALVDALVKAKPAASKGIYLRRVALSSTMGSGVRVEPSSINAA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: SDHF2_USTMA
Sequence: MTIRNVTRGLRCTLAFRTLPNALPVQASLCRVDCALLSTTCARRKSGLKADGSRADQAEAGASQSLDKQSRTLDSVRDDTLSDPYPLPFSPDIVELNSVKTRVEAGLESKWSGVNLASSQQTLNHIDAPMRVPGRDSEARETKIARLIYQTRKRGTLETDLLLSTFAKKELKNLPDAELDEFDRLLDEPDWDIFYWCTQRKPIPARWAHSFNTAGKLGHRLVAHTRNDEKAVRWMPEL
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 2, mitochondrial, SDH assembly factor 2, SDHAF2.
What is the protein family that this protein belongs to?
Belongs to the SDHAF2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: EFTS_ALKOO
Sequence: MDITASMVKELREKTGAGMMDCKKALTEAEGNMDRAVEVLRERGLAAVAKKSGRIAAEGLVESYIHGGRIGVIVEVNSETDFVAKNQEFKDFVKDVALHIAASNPQYVRREDVDPALVEKEKEILTKQALNEGKPEKIVEKMVEGRIDKFYKEICLLEQPFVKDPDVTVGDLLTEKISKIGENISIRRFTRYEVGEGIEKKEENFAEEVAKQMAQN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_HAEDU
Sequence: MMKHIDLKILDNRIGREFPLPTYATTGSAGLDLRALIDSAITVEAGQTVLIPTGISVYIADPNLAAVILPRSGLGHKNGIVLGNLVGLIDSDYQGPLMVSIWNRSDKPFTIEVGDRIAQLVFVPVVQASFNIVTDFEQTSRGEGGFGHSGKQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: TAX_HTL1F
Sequence: MAHFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQFLIPRLPSFPTQRTSKTLKVLTPPTTHTTPNIPPSFLQAMRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGGSVVCMYLYQLSPPITWPLLPHVIFDHPDQLGAFLTNVPYKRMEELLYKISLTTGALIILPEDCLPTTLFQPARAPVTLTAWQSGLLPFHSTLTTPGLIWAFTDGTPMISGPCPKDGRPSLVLQSSSFIFHKFQTKAYHPSFLLSHGLIQYSSFHNLHLLFEEYTNIPISLLFNEKEADDTDHEPQVSPGGLEPPSEKHFRETEV
What is the function of this protein?
Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways.  Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE).  Binding to TRE requires the interaction with CREB1 and CREBBP.  Also induces chromatin remodeling of proviral LTR-mediated gene expression by recruiting the histone acetyl transferases CREBBP and EP300 to the chromatin, which results in histone acetylation.  Via its interaction with IKK regulatory subunit IKBKG, Tax-1 persistently stimulates I-kappa-B kinase (IKK), resulting in constitutive activation of the transcription factor NF-kappa-B.  Induction of the nuclear expression of members of the NFkB family of transcription factors, which leads to up-regulated expression of many gene promoters containing NFkB motifs.  These genes include those encoding IL2, IL15, IL2RA and IL15RA, leading to autocrine IL2/IL2RA and IL15/IL15RA loops.  The resulting T-cell proliferation leads to malignant transformation and to the development of adult T-cell leukemia (ATL).  IL13, known to be linked to leukemogenesis, is also up-regulated by Tax-1.  Interaction with PDZ domain-containing proteins induce IL2-independent growth, which may be a factor in multi-step leukemogenesis.  Inhibits the action of at least three cellular tumor suppressors p53/TP53, RB1 and DLG1, and suppresses their abilities to dictate apoptosis in primary cells.  Required for viral replication (By similarity).
What are the official names of this protein?
Protein Tax-1, Protein X-LOR, Trans-activating transcriptional regulatory protein of HTLV-1.
What is the protein family that this protein belongs to?
Belongs to the deltaretrovirus Tax protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Shuttles from the nucleus to the cytoplasm. Found predominantly in the nucleus, where it is equally distributed between the nucleoplasm and the nuclear matrix (By similarity).