PharMolix/UniProtQA huggingface dataset:
Protein: YUEB_BACSU
Sequence: MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQIAVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKYDAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKMSALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDELKKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIRTGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGMKKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSDNKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDDSPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPEQDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKLEEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVNDAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKSTLNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFIDGMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTMALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNVASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIVLISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVFTILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYIDIQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA
What is the function of this protein?
Required for YukE secretion.  Probable component or regulator of the ESX/ESAT-6-like secretion system (BsEss) (PubMed:23861817, PubMed:24798022).  Bacteriophage SPP1 receptor.  Essential for the irreversible adsorption of the bacteriophage (PubMed:15576783).
What are the official names of this protein?
ESX secretion system protein YueB, Bacteriophage SPP1 adsorption protein YueB, Bacteriophage SPP1 receptor protein YueB.
What is the protein family that this protein belongs to?
Belongs to the EsaA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NHAA_SHESW
Sequence: MEKAIRNFLSQESAGGILLLVAVVFAMLMANSPLSGLYQGFLGTDVQVRVGALDIHKPLLLWINDGLMALFFLLIGLEVKRELLEGALSSVAQASLPSFAAIGGMLVPAGIYLLFNYGDPVTQAGWAIPAATDIAFALGIMALLGNRVPVALKVFLLALAIIDDLGVIVIIALFYSSDLSTISLAIASVAILGLVGLNRKGITALTPYGILGLILWVAVLKSGVHATLAGVIIAFCIPLRAKDGSSPSEHLEHSLHPWSNFLILPVFAFANAGVALGNMSLDTLLSPVPIGIALGLILGKPIGVMLFSFIAVKLKLARLPDNVGWMQIAPVAAMCGIGFTMSMFIASLAFEQADPMYGDLARLGTLIGSFIAALVGYFWLSKVLPKKGV
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CMOB_SHEAM
Sequence: MISFSSFYRQIADTQLQHWLESLPAILGEWQRQHKHGNLPKWEKVLAKLHYPAPEFLDLKDSVTIGDGLQLDSGQTEKLENLLKILQPWRKGPFHVHGIHIDTEWRSDWKWDRVSPHLSPLTNRTVLDVGCGSGYHMWRMLGAGAKRVVGIDPSALFLCQFEAIKRLIDTELPVHLLPLGIEELPPLDAFDTVFSMGVLYHRRSPIDHLLQLRDQLRMGGELVLETLVVDGDKDTVLVPQDRYGKMNNVWFLPSIDALKLWLEKCDFTDVRCVNVDVTSLAEQRSTPWMQNESLVDYLDPKDVNLTVEGYPAPKRATFIAVKNRSPQDAD
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: CBPM_PSEPK
Sequence: MSSTLIVQLDMRTLCQEADVTAECVIEIVEHGIVEPSGRTPEDWLFDDQAPLVTKRAVKLHQELELEWEGVALALELLQEVQQLRSENSMLKQRLGRFIQL
What is the function of this protein?
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA.  Together with CbpA, modulates the activity of the DnaK chaperone system.  Does not inhibit the co-chaperone activity of DnaJ.
What are the official names of this protein?
Chaperone modulatory protein CbpM.
What is the protein family that this protein belongs to?
Belongs to the CbpM family.
Protein: SYL_XANC5
Sequence: MSTVEPNVYDPQQVETSAQQFWDATRAFQVDENSEKPKFYCLSMLPYPSGALHMGHVRNYTISDVVSRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAKWTYANIEHMRAQLKSLGYAIDWSREFATCTPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPIDQTVLANEQVIDGRGWRSGALVEKREIPQWFLRITDYAQELLDGLDQLDGWPDSVKTMQRNWIGRSEGLEIQFDVRDIDGAPLDPLRVFTTRPDTLMGVTFVSIAAEHPLALHAAKSNPELAALLETLKHGGVSEAELETQEKRGMATGLTAVHPISGEQVPVWVANFVLMGYGTGAVMAVPGHDQRDFEFANKYGLPIVQVVKLREPRNEEEQTWDATHWRDWYTDKSRELELINSAEFDGLDFGGAFEALAERFERKGQGQRRVNYRLRDWGVSRQRYWGCPIPVIYCAKCGAVPVPEDQLPVVLPENVEFSGTGSPIKTDPTWRQTTCPDCGGPAERETDTFDTFMESSWYVARYTSPNARDMVDRRANYWMPADLYVGGIEHAILHLMYFRFYHKLMRDARLVDSDEPVTNLLTQGMVIAETFYRDADNGGKDWINPADVEIQRDERGRVTGAVLIADGQPVHIGGTEKMSKSKNNGVDPQSMVAKYGADTVRLFSMFAAPPEQSLEWNEAGVDGMARFMRRLWVQVHKHVGEGAAVALDVAVLSAEQKAIRRKTHETIGKVSDDYGRRHSFNTAIAAVMELSNALAKFDDASEQGRAVRQEALEAMVLLLNPITPHASHALWQVLGRGETLLENVAFPQADASALVRDALTLAVQINGKLRGTIDVAADATREQIEALAQAEPNAAKFLEGLSVRKIIIVPGKIVNIVAG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURR_YERE8
Sequence: MATIKDVAKHAGVSTTTVSHVINKTRFVAENTKAAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAPYFAEVIEAVENSCYSKGYTLILCNSHNNLDKQKAYLAMLAQKRVDGLLVMCSEYPEQLLGMLEDYRNIPMVVMDWGTARGDFTDSIIDNAFEGGYLAGRYLIERGHRDIGAIPGQLSRNTGGGRHQGFLKALEEANITLREEWVVQGDFEPESGYKAMHQILTQKHRPTAVFCGGDIMAMGAICAADELGLRVPQDISVIGYDNVRNARYFSPALTTIHQPKERLGETAFAMLLDRIVSKREDPQTIEVHPKLVERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: RL28_DESOH
Sequence: MARQCEICGKKPMVGANVSHAHNVTKRRFNPNLQRVRAVRDGKPQTLYVCTNCIKSGFVVKAA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: XIRP1_DANRE
Sequence: MAEVAKQKKATEAVCGDEDFPPPPPPLPRPQVLESLQKDLSQNFLPVPPPKETFSEIYQQRQKSELKRLFKHIHPELKMTVDDVVDDELIDAINPQAADAAYQGEVQSMRWIFENWTLDNIGDPHETKKLLCEENPQGGDVKGKSSLFEHSTFDSQHAAGAERAGVVRGDVRTATWLFETQPLDSISKSKIEDEEIVEVVLKEPVQKGDVTGARRLFETKPLDSLGRCCSVEDQHFLTLKSELQENKGDVKKTVKLFQADPCCALRDSNGKIHEIKSICREEIMSSDFKTARWLFETQPLDHINEGAHVQIIRGISLEEAQRGGVDKKKWMFETQPLDAIHEGVVEEQKFQGTAVEGFSGAADVHNKLQLFENQPLSSLKGDSEGDVLEKEAIVGGNVGSTLWLFETQPMDTLKDSYEVGRLQKVMVSSDEKGEVQDKRMQFEKSTAGKTAGDSGNKVQNDEKGDVKTFKSLFETLPLNVSEKAQSQIHDITSGDVKGHCSLFETTPLYAIKDCAGKFHEVTTVSREECIKGNVQNYKWMFETRPLDQFEEGSGKVELIKGITRQEDMTDDTRTAKWMFETQPLDCMSLNSRTDVDSTQKEFKKSNVKTCKWLFETKPMDMLYEKSEGKQDVEPVPKADVKSHTWLFETQPLDNIKDKENLGLKLCSTVQEDVKSDVNVKTVKHLFETEPLDRITDQADSGQNVRCVSQVDMQSGDVSRVKEIFESKSLGTESSKWSEEQKNEIQSGSVHKFTWLFENQPIGDINEKEERIVSCDVEAGDVGGKKFIFETLSLDKIKDKDELLEHPSMIIEKPLSSSVNVKSNTMLFESQPLYAIRDKDGQFHEVTTVMKEEVMRGDVRGARWMFETKPLDTIQADKEIYVIRAVTQEDVHKGDVKSARWKFETQPLDSFTPHEGPSVRVVEDIGNEKCVQQSRQLFETEQASQKKFVRMVSVTDVQQGDVRTSTWLFENQPIDTLKGEPDEQNNLTAVHREDNTKGDVKRCTWLFESQSLDKIKDNKPTEELVSSREEIPKADVKSTTWLFETTPLDKITVESVTDILYRLCHNSFIHSSGIIIQANDYKYVNMAKYQIMKDEGPKVLKEEVVEGNIRNLMLQLLFKPNIKPMVVLLKEDEQGKMHSTVLEIPFQQPGSATNPEAECKTQEAVKIIENLLVQQKEIKTGLVMQESEGGQPEMTVYSLHCESSLTESQTITRGDVKSTIGNLLATVHSQQTKQSCRMEEIERGNVNLYKSCIEKGDLKSLQRELSEEDLVTSCRDQIEIVQGDVKEAMRHLSQQREQVERTILDVVPGDVKNVKKVFSDVCTDLSIGNCVPREEIVRGDILSAKQQLGEAVKQQVMVQKEEIVSGDIKATLESLERAKQQSMQVEREVIKPGTIYDLNVEAEEMCSEENESKLVKEEIIPGDIKAAKRSLERAKNQSMKVEREPITPGKLYNLNETSQCQSSTTVEQSTTSTYSNHRITTTFRKVSDIEKDQESIKRLCCLNEVGGGGKNIYINTEDALRMVDISESVPDVVKGDVKATIQSLRSASTEQRSVDREEIVRGNMQETLQCLKKSSINISRGDYKAAMLYKQSGQPYTQSKITNDSGTKDCKQSFDHIPSSHTQLSSSVSVTRSEHPTSLALNSESVSSNADNSKNSSAFTGKDEHPPPILPKTGHQVKDQKPVIPPKPLHITTSSPPLFTETSNMCPNSTVSINDTQQTPAIPLKVTPSNKMFTHETEIAKTSNKIKDKESKIHEQVQRTNLTDPTDFQRMQYTEQWVQNSHMQITDTPSVNKTDSFKNGSFPGDSIGMEKNVVQRINAAEEIRMCYSKDNDELNKGFKAVLQNFGEKKTTTDTGSPFPKKIKVVQKENIQEQAKTSNKDELHFTSRDTSSTPNKHEVPSIHNNSENKVVLREKKAKRETEDERRQRLSIHRDEIMRGNVKAAMEIFENLMRREELKVILSKVQEIEGETFEVDVRSLKTLFENVPAWITNPKENTKRRHRPRVAKETEGLRDDLESISSVEAAFEDLEKASMDIVNLKEQTLAKLLDIEEAIKKALYSVSNLKSEADIAGLSGLFSESLSPDNVSPSTKNIRKISIVSSKTKPAQSNQMQSADNRALYKEVPHVPQVQVSKQSSNVPSSPSFISIHSAARKPAESPTDKPKTNADQSNAGSSSSQNSSASHICSPPSPRRKVSVLEVQRVPEVPSGIFGTKTVSEKYEETDCFGNTYYSSKRSTFVTRQSETELSSSYDVVTSPRRSEGMTSPVLQRSGQSFSSNSLSKGKDRKVFVTFGHPNTEKH
What is the function of this protein?
Protects actin filaments from depolymerization.
What are the official names of this protein?
Xin actin-binding repeat-containing protein 1, Cardiomyopathy-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the Xin family.
What are the subcellular locations of this protein?
Cell junction. Note=Colocalizes with actin stress fibers.
Protein: RL5_BORPA
Sequence: MSRLQEFYKSKVVADLQAKFGYKCVMEVPRITKITLNMGVSEAVADKKVIEHAVSDLTKISGQKPVVTKTRKAIAGFKIRENYPIGCMVTLRGQRMYEFLDRLVAVALPRVRDFRGISGRAFDGRGNYNIGVKEQIIFPEIEYDKIDALRGLNISITTTAKTDDEAKALLTAFSFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: LPTE_ECOUT
Sequence: MRYLATLLLSLAVLITAGCGWHLRDTTQVPSTMKVMILDSGDPNGPLSRAVRNQLRLNGVELLDKETTRKDVPSLRLGKVSIAKDTASVFRNGQTAEYQMIMTVNATVLIPGRDIYPISAKVFRSFFDNPQMALAKDNEQDMIVKEMYDRAAEQLIRKLPSIRAADIRSDEEQTSTTTDTPATPARVSTTLGN
What is the function of this protein?
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.  Required for the proper assembly of LptD.  Binds LPS and may serve as the LPS recognition site at the outer membrane.
What are the official names of this protein?
LPS-assembly lipoprotein LptE.
What is the protein family that this protein belongs to?
Belongs to the LptE lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: TOB1_RAT
Sequence: MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKQKYEGHWYPEKPYKGSGFRCIHVGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDSNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSSKVARTSPISLGLNVNVNDLLKQKAISSSMHSLYGLGLGSQQQPQPQPQQPPSQPPPPPPPPQQQQQHQQQQQQQQQQQQQPQQQTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFNVFAAYGGLNEKSFVDGLNFSLNNIQYSNQQFQPVMAN
What is the function of this protein?
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex.  Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.
What are the official names of this protein?
Protein Tob1, Transducer of erbB-2 1.
What is the protein family that this protein belongs to?
Belongs to the BTG family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Only a small fraction localizes to the cytoplasm except in late S- phase where more than half of proteins become cytoplasmic.
Protein: S5A4A_MOUSE
Sequence: MASTASVSTSTASSELSSLSNNINNAADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNLTINSRCYTPQPDSFHIFRDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPMLVLKLMPPGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSYGTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNSKEERIDLDAEDKEENGADDRTEEDQTEKPRGCLKKTCDLFCGLQRAEFKLTKVEEEALTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA
What is the function of this protein?
Has sugar-induced sodium-independent electrogenic activity.  Generation of glucose-induced inward currents is pH-dependent, with activity in acidic conditions (pH 5) but not neutral conditions.  Does not have sugar transport activity.
What are the official names of this protein?
Solute carrier family 5 member 4A.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CHS9_MEDSA
Sequence: MVSVSEIRQAQRAEGPATIMAIGTANPANCVEQSTYPDFYFKITNSEHKVELKEKFQRMCDKSMIKRRYMYLTEEILKENPSVCEYMAPSLDARQDMVVVEVPRLGKEAAVKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPYVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEVTAVTFRGPSDTHLDSLVGQALFGDGAAALIVGSDPIPEIEKPIFEMVWTAQTIAPDSEGAIDGHLREAGLTFHLLKDVPGIVSKNIDKALVEAFQPLNISDYNSIFWIAHPGGPAILDQVEQKLGLKPEKMKATREVLSEYGNMSSACVLFILDEMRKKSAQAGLKTTGEGLDWGVLFGFGPGLTIETVVLHSVAI
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 9, Naringenin-chalcone synthase 9.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: BACH_MOUSE
Sequence: MKLLVGTLRLWEVGRQVAFSSLTPGQECSGLRKTFWAAMRAVRTRADHQKLGHCVTMGRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVHVMSENILTGTKKLTNKATLWYVPLSLKNVDKVLEVPPIVYLRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDNSQKRYRAASAFFTYVSLNQEGKPMPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHTEPQP
What is the function of this protein?
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (Probable).  Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (Probable).  May play an important physiological function in brain (Probable).
What are the official names of this protein?
Cytosolic acyl coenzyme A thioester hydrolase, Acyl-CoA thioesterase 7, Brain acyl-CoA hydrolase, BACH, CTE-IIa, CTE-II, Long chain acyl-CoA thioester hydrolase.
What are the subcellular locations of this protein?
[Isoform A]: Cytoplasm, cytosol. SUBCELLULAR LOCATION: [Isoform D]: Cytoplasm, cytosol.
Protein: ACT1_DICDI
Sequence: MDGEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAEMQTAASSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
What are the official names of this protein?
Major actin, Actin A1, Actin A12, Actin A8, Actin III, Actin M6, Actin-1, Actin-11, Actin-12, Actin-13, Actin-14, Actin-15, Actin-16, Actin-19, Actin-2, Actin-2-sub 1, Actin-20, Actin-21, Actin-3a, Actin-4, Actin-5, Actin-6, Actin-7, Actin-8, Actin-9, Actin-IEL1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MED19_YEAST
Sequence: MASRVDETTVPSYYYYVDPETTYTYQQPNPLQDLISVYGLDDISRQVARTNLDGTKAVKLRKSYKNQIADLSGKFSTIPTRENGKGGQIAHILFQNNPDMMIQPPQQGQNMSEQQWREQLRNRDIALFQPPNFDWDLCSSVLSQFERSYPSEFANQNQGGAQAPFDIDDLAFDLDGTGKSQSGSNSGNNSKKRKNKSSGSSMATPTHSDSHEDMKRRRLE
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II.  The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 19, Hypoxic gene repressor protein 3, Mediator complex subunit 19, Negative regulator of URS2 protein 3, SNF1 suppressor protein 7.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 19 family.
Protein: ATPL_FUSNN
Sequence: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPD_PSYCK
Sequence: MESTHEYCIMNTTPNIHAMIVAAGRGSRFGASIAKQYTLLQGQTLLQHSVARLAESNYIDRCLLVVAQDDSTAQTLSFALPIYYAIGGTERWQSVQAGVEAMINAGADESDLVVIHDAARPAVPTHDIDAVIQAAMLEPYGAILATPVADTLKQSYIASNTLSTPAYEAPLSLQQLNTQPELANSQSGYDTLHTYAQKTIDRSHMWQAQTPQVFRLGQLQQVLNYVTKHNLAITDEASAFEHLELPIRLVTGSRQNIKLTYPDDIILLTAILKAQFASIS
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: TRAD1_RAT
Sequence: MAEFPDDQAARLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMDIHVATEHCQVTCKCNKKLEKRQLKQHVETECPLRLAVCQHCDLELSVVKLKEHEDYCGARTELCGSCGRNVLVKELQTHPAVCGRVEEEKRSEAAVPPEAYDEPWSQDRIWIASQLLRQIEALDPPMRLPGRPLRAFEADPFYSRTASQRGVTAHFPIQNNLFEEQERQERNRSHQSPKDSAENSAHLDFMLALSLQNEGQASSMVEQGFWESVPEADPARAGPTSLGDIKGAADETLLPCEFCEELYPEELLIDHQTSCNPSHALRSLNTGSSSIRGVEDPGAIFQNFLQQATSNQLDTLMGLSSSAAVEDSIIIPCEFCGVQLEEEVLFHHQDQCDQRPATANHRAMEGIPTQDSQPEDRSPELSRRRVKHQGDLSSGYMDDVKQESVKGSTYSLSPNRTMNNVSTCNRLLNSSGPRSDCQRSPPGVLKLNNSGSQDIRGRIRGSQNGPIASAHAPVIHSIRNLYPENLAPSFPHGSPGRFGASEGSRSSRVTPTAASYHSRAAKAKPPKQQGAGDAEEEEE
What is the function of this protein?
Negative feedback regulator that controls excessive innate immune responses.  Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways.  May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation.  May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).
What are the official names of this protein?
TRAF-type zinc finger domain-containing protein 1, Protein FLN29.
Protein: ARLY_ANADE
Sequence: MRANSKAKPVSRAALAGEADPRLVALSVSIQDDGALYAEDIRGSQAHVSMLAAQGIVPKAAARRIVAALDQVRAEFAAGRIRFDPALEDVHTHVERRLGELVGKDAGYLHAGRSRNDQVALDERLFIVGACDRCDAALERLQRAFLGQARAHERTILPGYTHLQRAQPVSLAHHLLAYVEMFGRDRERFAEVRRRAAVSPLGSGALAGTTLPLDREAVAARLGLAGVTHNSLDAVSDRDSAAELLFACALAAVHLSRIGEELVLWTTKEFGFATLSDAFATGSSLMPQKKNPDVGELARGRAGRALGDLVALLAILKGLPLSYNRDLQEDKRPLLGGPEALVLTADAVAGAVGTATFHAERMEEALGSGEALATDAAEYLVERGVPFREAHEAVGKAAAFSAREGRPMARLTAAEWASFHRRFEKDVLRCFDARRSLKRRELPGAPGPRAVRAELRRWEKALGKARR
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX826_LYCSI
Sequence: MKLMIFTGLVLFAIVSLIEAQAENEKPCLPEYKVCTHVPGNCCSDLVCDCYGRYKSGAQIGRNCFCLQKGVIYKREN
What are the official names of this protein?
U8-lycotoxin-Ls1p, Toxin-like structure LSTX-H26.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 08 (U8-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS4_BACFN
Sequence: MARYTGPKSRIARKFGEGIFGADKVLSKKNYPPGQHGNSRKRKTSEYGIQLREKQKAKYTYGVLEKQFRNLFEKAATAKGITGEVLLQMLEGRLDNIVFRLGIAPTRAAARQLVGHKHITVDGQVVNIPSYAVKPGQLIGVRERSKSLEVIANSLAGFNHSKYAWLEWDEASKVGKLLHIPERADIPENIKEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: TRUA_FRACC
Sequence: MTDGLVRLRLDLSYDGTPFAGWARQPGQRTVQGDVEDALMRVARLPAVRLTVAGRTDSGVHAVGQVAHVDLPDDVPLGGLARRLNGVLDRAVRIIGLAPAPPGFDARFSALSRRYVYRITDAPYGAEPLRRFDTLAWPRPLDVPAMAAAALFLVGEHDFAAFCRRREGATTVRTLLRLDVLRRPEGVVVADVEADAFCHSMVRALVGALLAVGEGRKPPQWPAAVLHRGVRDPAVTVAPAHGLTLVDVRYPPDPELAARAEVTRAVRIPPTPSG
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GG6L2_HUMAN
Sequence: MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPETTTSEGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDVETGGEAAGAGEADVGAGGEDAGSGAEDVGPGGEDVGAGREAAGEGGENAGAEEDVAAGGEDAGGEEDAGAGEEDMGPGGEDARGGEDAGAGEEDAGGGGDDAGAGGEDAGAGREDAGAGGEDVGAGREDAGAGGEDVGAGGEDVGAGRRRCGSSRGCRNRRRSCGNTRRCRSRRSGAEDVGPEGEDVGAGREAAGEGGENAGAEDVAAGGEDAGEEEDAGGEDAGAAREDAGAGGDDVGAGREDAGAGGEDVGAGGEDAGAGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDVGPGGEDVGAGGEDVGAGGDAREGGEDTRSEREDAGEAARARGAVLRALPPSLQSSL
What are the official names of this protein?
Golgin subfamily A member 6-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the GOLGA6 family.