PharMolix/UniProtQA huggingface dataset:
Protein: GCN2_SCHPO
Sequence: MDAAKRLELCKEIQENEIEALKAIFMDDFEELKVRNAWNVTNGHVYCIHLCSRSANSKSIAKLDLCIELGRSYPYVKPVIKLQNGENVLNSQIRFLLDKLDTKAKDLLGEEMIFELASIVQDYLNDWQSDLSSQFASLEEERAVQLKHDRERAEVDLQLRLKREKDALFEEEQTLQNKIQDELQRRSYETPQSSSKKKTNSKETTSLETLPTSIYFDCSISVRDCHDSLVTFNRVLPLYTISHSNLSTLTLVKPESKEISLQDCVFLLRTVRISTPYWSTEDGKREIQELEYELESLKVIRHDLLASIYEYQLERETRGYGWRLYVLQEYSPKFTLFSLLQTVLTLDVETVRAFSNNILEGLAELHRLGISHKSLHLDNVVLFHSGHRTFAKLMDFGFTRTLRDMNASHPFNINSQSITNILPEGLYPPEVSESSFAAASRKTDIWCFGLLVLQMLCGAHVLNKFSSLKLIMTHVIPLLPGSYQDLVRRCLMRDSRKRPSAIDLLSSHVIRLGTAVLPPVEQGTFSKSARPSYGGQQDGIIDLLYRKSVSRYETDFEELEFLGRGGFGEVVKVKNRIDGRFYAVKKLVLLSDDKENSRILREVMTLSRLHHEHVVRYYTAWVETEANDTVTEIISSDSESLSQSLNMAVDFRQSSSLPADKLSSLDIHFEDDYNSSADEEDPEASDISFQYSNTSDKEGSSDKDSSIEEASSVKTQENGLNATLYIQMEYCEKLSLQDIIRDKIPVDEMWRLFRQILEALAYIHSRGMMHRDLKPGNIFLDENRNVKLGDFGLATENENYQDNNDKWKNRQSADEDLTTGVGTALYVAPELLSRRNGVRYDAKVDMYSLGIILFEMCMTFSTSMERIRIIDTIRSPSISFPSTFPFSRASHEFKVIHCLLQHDPTKRPSSQELLESEAIPPKVGEEFIQEGLRLLSNPNTPYYLKLLKVLFGQVPDRHKDFTYDFNLSEESGVLSKVSDRGWDSLLACLVRDHVVKVFRRHGAKERESHILFPKSSQYDKDQASVSLLDKNGTLLQLPYDTVLPYARNVARNAVEEEKTYLISDVFREAKGGGRPKAIKEISFDITTNSDNLDWYDAETIKALDEVLTEIPSLTESCILINHADILSSILDYLQVSKDKRRMATHILGQINQRLTLSQVRNQLRIESLVPSTTLDDLSLFDFRENYEEGASKLRKIFGKEMPQKMRTALNYMERVVKLLRALKISHQLYFMPLCVYNFEFYDGGLMFQAINLAEKSELICAGGRYDKLVRFFDPPLMRTARKKHVVGICFALEKLVFSMLRYIRFHNSKQSSKHSPSPTLKSVGPWAPRRVDVLVTSIGKDSILEKCSLLQELWALNIQADIVLRGASSLEEIVTHYRSEGINWVLVVRQKNTQMEHSVKARNILKNEDDEIRFDEVGMWLLGEINERKRNESMLQSKRILDSAQQDVAKFVDTSQSNLDVQLISLKDVNDRKYKWKHKQNAMNKVYDLVQSAIRESSEDAIALAVDCDSEAMEKLRSTTTLDEESWKRLIESCPASQREYMQRLQKKLVTLAEQDKKRVWICSFRTNEIYLYGLK
What is the function of this protein?
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/tif211) on 'Ser-52' in response to low amino acid availability (PubMed:15611163).  Plays a role as an activator of the general amino acid control (GAAC) pathway required for adapatation to amino acid starvation (PubMed:15821139).  Converts phosphorylated eIF-2-alpha/tif211 either to a competitive inhibitor of translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator fil1, and hence allowing fil1-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:15821139).  Binds uncharged tRNAs (By similarity).
What are the official names of this protein?
eIF-2-alpha kinase GCN2, Serine/threonine-protein kinase gcn2, Serine/threonine-protein kinase ppk28.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC1_SOLLC
Sequence: MASFVPTKQFVGASSSSDIGSSRLVSLQLPSKFSSSNFHLPSRPSQLKRLEIQAAGSTFGNYFRVTTFGESHGGGVGCIIDGCPPRLPLSESDMQVELDRRRPGQSRITTPRKETDTCKISSGTADGLTTGSPIKVEVPNTDQRGNDYSEMSLAYRPSHADATYDFKYGVRSVQGGGRSSARETIGRVAAGAVAKKILKLYSGAEVLAYVSQVHQVVLPEDLIDHQNVTLEQIESNIVRCPDPEYAEKMIAAIDAVRVRGDSVGGVVTCIVRNLPRGLGTPVFDKLEAELAKACMSLPATKGFEFGSGFAGTFMTGSEHNDEFYMDEHGRIRTRTNRSGGIQGGISNGEVINMRIGFKPTSTISRKQQTVTRDKHETELIARGRHDPCVVPRAVPMVEAMVALVLVDQLMAQYSQCMMFPINPELQEPLQSSPESAEVTL
What is the function of this protein?
Catalyzes the last common step of the biosynthesis of aromatic amino acids, produced via the shikimic acid pathway.
What are the official names of this protein?
Chorismate synthase 1, chloroplastic, 5-enolpyruvylshikimate-3-phosphate phospholyase 1.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UFM1_DROGR
Sequence: MSKVTFKITLTSDPKLPFKVLSVPEATPFTAVLKFASEEFKVPPETSAIITDDGIGISPQQTAGNVFLKHGSELRLIPRDRVGH
What is the function of this protein?
Ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.
What are the official names of this protein?
Ubiquitin-fold modifier 1.
What is the protein family that this protein belongs to?
Belongs to the UFM1 family.
Protein: SEPF_LACAC
Sequence: MAFDKLGRFFGISNDDELANDEEYTTQNEENNEDLPLNSINRDNVVSIKSGLNSSKSKIVLYEPRVYSDAKDVAQNLLNNKAVVINFSRMEDSSARRIVDFITGTVYTLNGEIQRIGDKIFLATPPKFVTDGKISDLVDKKDNLS
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: FOLD_PELPD
Sequence: MAHIIDGKAIAAKIRSEIASGVRELQGKGVTPGLAVVLVGDDQASRVYVSMKEKACNDAGIFSVEHKLAAETSEAELLALVELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVDGFHPYNVGRLSVGKPVFQPCTPYGVMVMLREAGVELKGKEVVVVGRSNIVGKPVAMMCLAEHATVTLCHSRTRDLPDVVRRADVVIAAVGRPEMIKGDWIKEGAVVIDVGINRVGEKKLVGDVEFAGASQRASAITPVPGGVGPMTITMLLQNTLESAKRGMAE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CGLR1_DROME
Sequence: MAMNLENIVNQATAQYVKIKEHREPYTAHYNALKDKVYSEWKSSAVLGKLLKGSTLCGGYGDKLKVSIPDEFDLLIHLVFPENDKIIVKADASKPGNVILDMTKVMEIIGSQEHNKPVFDRLQKIVNNKKQLLEDKLNSFLESIMTQTLNKMGNQIEVAGRISHLQYKKCGPAHTIFVKGSCKYSVDFVPAIRLSAAQVVLAPEQRIHFGETLYWDAIPKPMKPAKTDNTSFTSSFYEAERRLLYGKQFLKPAIRLMKQNRNVKNKANLKSYHIKTLFLWQVIQQDPSYWSNSPKDIFIEMLGKLADSLALTPKKGKLPFFWDPKLDMFAQLTDSQRTDLYNHFRKCEYTFRKDNGNVNDCTENNVHSSFSKNTTYKL
What is the function of this protein?
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in antiviral innate immunity (PubMed:34261127, PubMed:34261128).  Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG (PubMed:34261127).  Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:34261127).  Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:34261127, PubMed:34261128).  3',2'-cGAMP is protected from poxin cleavage (PubMed:34261127).
What are the official names of this protein?
Cyclic GMP-AMP synthase-like receptor 1, cGLR1.
What is the protein family that this protein belongs to?
Belongs to the mab-21 family.
Protein: TBA_AVESA
Sequence: MREIISIHIGQAGIQVGNACWELYCLEHGIQQDGTMPSDTTVGVAHDAFNTFFSETGAGKHVPRAIFVDLEPTVIDEVRTGAYRQLFHPEQLISGKEDAANNFARGHYTVGKEIVDLCLGRVRQLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQIISSLTTSLRFDGAINVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVPEITNAVFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVVTIKTKRTVQFVDXCPTGFKCGINYQPPSVVPGGDLAKVQRAVCMISNNTAVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAXLEKXYEEVGAEGADDEVTRG
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PURQ_FRACC
Sequence: MTEADSPARIGIVTFPGSLDDQDTALAVRAAGAEPVSLWHGDSDLAGVDAVILPGGFSYGDYLRAGAIARFSPMVAALVPAARAGLPILGICNGFQVLCEAGLLPGALTRNVGLHFVCRDQRLRVEAPGTAWTRGYQDGEEIVIPVKHGDGRYVAAPDVLAELEAAGRVVVRYVGGNPNGSAADIAGICNESRTIVGLMPHPEHAVDDLTGPGVDGLRMFTSVLSGFLSAFSS
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCNKH_HUMAN
Sequence: MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPLLFSHMEGWSYTEGFYFAFITLSTVGFGDYVIGMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSCCHHSSKEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGIIQHLEPSAHAAGCGKDS
What is the function of this protein?
Outward rectifying potassium channel.  Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
What are the official names of this protein?
Potassium channel subfamily K member 17, 2P domain potassium channel Talk-2, Acid-sensitive potassium channel protein TASK-4, TWIK-related acid-sensitive K(+) channel 4, TWIK-related alkaline pH-activated K(+) channel 2, TALK-2.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: QUEC_SHEHH
Sequence: MSKAVVVFSGGQDSTTCLIQALQQFDEVHGITFDYGQRHREEIEIAKELATNLKLASHKVMDVTLLNELAISALTRDSIPVSNELMDNGLPNTFVPGRNILFLTLAGIYAYQLGADTVITGVCETDFSGYPDCRNDFVKAMQAALEQGMDKKLTIQTPLMWLDKAETWALADKFDSLELVRNETLTCYNGIKGDGCGTCPACLLRKRGLEEYLADKEAIQARLSAKCEN
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: MQO1_STAAM
Sequence: MTTQHSKTDVILIGGGIMSATLGTLLKELSPEKNIKVFEKLAQPGEESSNVWNNAGTGHSALCELNYTKEGKDGTVDCSKAIKINEQYQISKQFWAYLVKTGQLDNPDRFIQAVPHMSFVIGEDNVAFIKSRVATLKKSVLFEKMKLSQDEEEMKSWVPLMIEGRKSDEPIALTYDETGTDVNFGALTAKLFENLEQRGVGIQYKQNVLDIKKQKSGAWLVKVKDLETNETTTYESDFVFIGAGGASLPLLQKTGIKQSKHIGGFPVSGLFLRCTNQEVIDRHHAKVYGKAAVGAPPMSVPHLDTRFVDGKRSLLFGPFAGFSPKFLKTGSHMDLIKSVKPNNIVTMLSAGIKEMSLTKYLVSQLMLSNDERMDDLRVFFPNAKNEDWEVITAGQRVQVIKDTEDSKGNLQFGTEVITSDDGTLAALLGASPGASTAVDIMFDVLQRCYRDEFKGWEPKIKEMVPSFGYRLTDHEDLYHKINEEVTKYLQVK
What are the official names of this protein?
Probable malate:quinone oxidoreductase 1, MQO 1, Malate dehydrogenase [quinone] 1.
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: CM35_CONRE
Sequence: MMFKLGVLLTICLLLFPLTGTALDGDQLAEHMLDISSGINDRWFDPVRKCCMRPVCTCPCCS
What are the official names of this protein?
Conotoxin reg3.5, Rg3.5.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CH603_BURCH
Sequence: MTAKDVKFRDGARQQIVKGVNVLADAVKVTLGPKGRNVVIERGFGAPVITKDGVSVAKEIELKDRFENMGAQIVKQVASKTADVAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGIDKAVGAVLDELRKLSRPISTHKEIAQVGAISANSDEAIGKIIADAMEKVGKDGVITVEDGKSLENELDVVEGMQFDRGYVSPYFINDPAKQAAYLDDALILLHDKKISSVRDLLPILEAASKAGKPLLIVAEDVEAEALATLVVNSMRGILKVAAVKAPGFGDRRKAMLEDLAILTGATVISEETGKQLDKATLEDLGSAKRVEVRKDDTIIIDGAGDAARIEARVKSIRVQIDEATSDYDREKLQERVAKLAGGVAVIKVGAVTEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALLRARAALSDIRGANADQDAGIRIVLRALEAPLRVIAANAGDEPSVVISKVLEGKGNFGYNAATGEYGDLVDAGVVDPTKVTRTALQNAASIASLVLTTDATVAQAPKEESAESAPAPELGY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 3, 60 kDa chaperonin 3, Chaperonin-60 3, Cpn60 3.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDCA2_MOUSE
Sequence: MDASSHDKPLSESKECVLNNSENDVFRLGTEPFVTPQKHVADATPNLCTPDTFKSPLDFTTVTVEQLGITPESFVKTSSGKSTSSLQKARRRSTVGVRGSPETNCLIRFIAQQRNLKKAVLSPLAREPHFEGSPRLYRNASVLRERMSAFRSAFHSIQETKMASSPSAAEADGESRISDLTRKEDLLEYQQSGFPVNSSSKRRRISSQDSPDNYLSGTKALADEACAGGASTDLAEKSPDIGSAQPGCMAAPLPELRETSQGLAVTDCVEGPVTPLSSGTATATRSPETPMCGSSSPSAKTTATRSPATPVCGSSTPSAKTFVLRSVLKKPGKLFSENGKESNLCDDGAHLISYPSNSCKEGRAGRENCKTPGCLNPRKRKRVTFGEDLSPEVFDESLPANTPLCKGGTPVRPRTVKTTSPLQSPVHEQFLQPNFDDKEENLENIEPPQGSFANLSLSKSSLSETPPGTNTCSSLNKDEEIICSIVRPTRTSQRRKQTLSSTGVCSSYTTQAEPRKEKMSRRKSREKKHTSAALPKKKQVLKSYRKKKKGKKDVEKCFYGPRDIASKKPLLSPIPELPEVSEATPLADCTQGTSSDDFNKCGQLEEVNSFEIPTQRKRRLPQKADSPELDPAHHQSQVSDKCCYLLPLTTASERGPNASTRDTGSEGNTRAESKCQSAKEPKPGTKMESGLVPRASVTQDHIVSKNPKPLGSPQSQDLFKAGQNLENPCEILIVSESMNLKCEKESECLAPQGSLQGSPVSTDSKRDLNCSEDVLIQNIKEPASHSENVGRKCAGNGSPGSGRERKWRRRTVCCGGQSSYLEQNGNPASSCSGENFVEISLESVQLIEELSNTIEQSFQRTSSKTKVRRSTRLQRDLENTGLVWLSPSPSTLQKPRRRMTICTLDSRGFECPSSKEETISSGQNPGPLPAVSGSESQGVGSSALPRKRRSLCGSTLTDANSATQPPDCKRKPSLKGESAQLP
What is the function of this protein?
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase.  Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase.  At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity).
What are the official names of this protein?
Cell division cycle-associated protein 2.
What are the subcellular locations of this protein?
Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin (By similarity).
Protein: PB2_I77AF
Sequence: MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIMEMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSDSQLTITKEKKEELQDCKIAPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMIGILPDMTPNAEMSLRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWEMIKIQWSQNPTMLYNKMEFEPFQSLVPKAARAQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGSLTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: EFTU2_ORITB
Sequence: MAVAFNRDKPHCNIGTIGHVDHGKTSLATAITIVSSELSGGAVKVKNYDEIDSAPEERARGITIQTAHVEFISKKRHYALVDCPGHVDYIKNMITGASQTDGLILVVSGVDGVMPQTREHVLLAKQVGVPSIIVCINKIDQADPELLELIEMEVRELLTKYDFPGDTVPIIRCSALKAINGDSDAKKGILELMDSIDDYIPQPTRVLDQPFLMPIEDVFSILGRGTVVTGRIERGVIKVGDEVEIVGLRSTQKTICTGVEMFKKELDQGQAGDNVGILLRGIKREDVERGQVLAKPGTITPHCSFEAEVYVLTKEEGGRHTPFFQNYRPQFYCRTTDVTGEIALLSGKEMVMPGDHATLSVNLVAPIAMDQGLSFAIREGGKTIGAGKVSKIIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GH109_STRFL
Sequence: MNDDARPAPEPQDIPPHSGAADEVNRQDPSRRSVLWTTAGVAGAGLGLGALGAGTASAAGRSAPDAVAAAEAVAAAPPRQGRTMAGVPFERRSTVRVGIIGLGNRGDSMIDLFLALPGVQVKAVCDTVRDKAEKAAKKVTAAGQPAPAIYAKDEHDYENLCKRGDIDFVYVVTPWELHFPMAKTAMLNGKHVGVECPIAMRLEELWQLVDLSERTRRHCMQLENCCYGKNEMRVLRMAHAGLFGELQHGAGAYNHDLRELMFDPDYYEGPWRRLWHTRLRGDLYPNHGFGPVANYMDVNRGDRVVSISSVGTTPLGLAAYREEHMPAGDPSWKESYIGADRTISLVQTAKGRVIRLEHDVSSPHPYSRINSLGGTKGVFEDYPERIYLEPTNTNHQWDDFKKYAEWDHWLWKEHANPPGGHGGMDYIMVFRLMQCMRLGLVPDFDVYDAAVWTAPVPLSHLSIKAKGVPLPIPDFTRGEWKKTRSGMDSEKPAE
What is the function of this protein?
Glycosidase.
What are the official names of this protein?
Glycosyl hydrolase family 109 protein.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.
Protein: HBEAG_HBVA3
Sequence: MQLFHLCLIISCTCPTVQASKLCLGWLWGMDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVGNNLEDPASRDLVVNYVNTNVGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRDRGRSPRRRTPSPRRRRSPSPRRRRSQSRESQC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: RS19_ARGIR
Sequence: MGISVKDVDSHTFTKALAAFLKKSGKMKIPEWATIIKLSKFNELSPYDEDWFYTRAASICRHLYIRSPAGVGALTKIYGDRKRNGTVPSHYCRSSGSVARRVLQALETQKLVEKDANGGRKLTSQGQKDLDRIAAQVKEKTKSK
What are the official names of this protein?
40S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS19 family.
Protein: TSAC_HAEIN
Sequence: MNREQIADALRQNQVVAYPTEAVFGLGCNPQSESAVKKLLDLKQRPVEKGLILVAPSLDFFRPFVDFEQINDEQLSRLQGKYERPTTWIVPAKSTTPHFLTGKFDSIAIRLCDHPSVKALCELTGFALTSTSANLTGEPPCRTADEVRLQFGSDFPVLNEMVGRAHNPSEIRDLRTNQLFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_LACLA
Sequence: MSENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVLISGTDGVGTKLMLAIQADKHDTIGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQVVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVGVAEKSQLIDGEKDVEAGDVLLGLASSGIHSNGYSLVRKVFSDFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQNKIKGIAHITGGGFHENLPRMFGNSLSAEIVEGSWNILPIFKALEKYGDIKHEEMYEIFNMGIGMVIAVAPENAEALKKVLNAFEIGKMVKRQDSAVVIKK
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2036_BRUMB
Sequence: MENEPDTICILVDADACPVKAEIYRVAERHNLPVVIVANSFIAIPREAQRVERVVVSGNLDAADDWIAEHSRPGAVVVTADIPLASHALEKGASVIAPNGRIHTQSTIGNTLATRNLMDSLRSAGEVTGGPAPFAPKDRSAFLSALDLAIVRLKRAGFHAS
What are the official names of this protein?
UPF0178 protein BMEA_A2036.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: IORF_CVHN2
Sequence: MLEVEAPLEIVQESSRKLLGLTNLSEAIKPIIEAENPNPNSLCLLNHKETLSHIIPGSLGLPNFKKVETLNFQMVKEYPLLTGYPLLKQKDIGINTTGVLLKQLMVNKSSCYQDGISTISVPVHMPVHPMVMPTKVSSGSLVTKLTLLFPPMFRQGILLFKKLSLLGFRLVRFCLKAIMLKAQEGLLLIAGQVHVLNHVDPIIVH
What is the function of this protein?
Structural protein that is not essential for the viral replication either in tissue culture or in its natural host.
What are the official names of this protein?
Protein I, Accessory protein N2, N internal ORF protein, IORF, Orf8 protein, Protein in nucleocapsid ORF.
What is the protein family that this protein belongs to?
Belongs to the coronavirus I protein family.
What are the subcellular locations of this protein?
Virion.
Protein: MICU3_MOUSE
Sequence: MAALRRFLWPPPRLSPALAPQQPFLSPWGRPAGTAPGMSGRPFSCREEDEGAVAEAAWRRRRWGELSIAAAAGGGLVGLVCYQLYGDPRADPSELAAPELEDPPRGRGLLPIPVAAAKETVATGRAITEDLDLYATSRERRFRLFASIECEGQLFMTPYDFILAVTTDEPKFAKTWKSLSKQELSQMLSETPPVWKGSSKLFRNLKERGVISYTEYLFLLCILTKPHAGFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKRETKGDEEKRAMLRLQLYGYHSPTNSVLKTDAGELVSRSYWDTLRRSTSQALFSDLAERADDITSLVADTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVLEIEFLSYSNGMNTISEEDFAHILLRYTNVENTSVFLENVRYSISEEKGITFDEFRSFFQFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKLSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKDRLHRGFRGYKTVQKYPTFKSCLKKELHSR
What is the function of this protein?
May play a role in mitochondrial calcium uptake.
What are the official names of this protein?
Calcium uptake protein 3, mitochondrial, EF-hand domain-containing family member A2.
What is the protein family that this protein belongs to?
Belongs to the MICU1 family. MICU3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single-pass membrane protein.