PharMolix/UniProtQA huggingface dataset:
Protein: RLMN_SHEB9
Sequence: MSEKKINLLDLDRKAMRALFADMGEKPFRADQLMKWLYHFGVSDFEEMTNINKVLRQKLAARCEIVAPEISSFQKSTDGTIKFAINVGQGQEVETVYIPEDDRATLCVSSQVGCALECTFCSTGQQGFNRNLTVSEIVGQIWRVSHFLGFAKDTGERPITNVVMMGMGEPLLNLANVIPAMDIMLDDFGFSLSKRRVTLSTSGVVPALDKLGDAIDVALAVSIHAPNDELRDILVPINKKYPLDEFLAGIRRYIAKSNANRGRVTVEYVMLDHINDSTDQAHELAKLMKDTPCKVNLIPFNPYPGSPYGRSSNSRIDRFSKVLMEYGFTVIVRKTRGDDIDAACGQLAGDIRDRTKRLAKKRMQENQISVTMN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_SALSV
Sequence: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHIGQMLLTRADMEDRERFLNARDTLRALLDNHIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQQGLFTADPRSNPQAELIKDVYGVDDALRSIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIASGSKPGVIGDVMEGISVGTRFHAQASPLENRKRWIFGAPPAGEITVDEGATAAMLERGSSLLPKGIKSVTGNFSRGEVIRICNLQGRDIAHGVSRYNSDALRRIAGHHSQQIDAILGYEYGPVAVHRDDMITR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDCB_STAAR
Sequence: MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQSITKGNVFLKLENMQFTGSFKFRGASNKINHLTDEQKEKGIIAASAGNHAQGVALTAKLLGIDATIVMPETAPQAKQQATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDDKFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQSENVHGMAESFYKRDLTEHRVDSTIADGCDVKVPGEQTYEVVKHLVDEFILVTEEEIEHAMKDLMQRAKIITEGAGALPTAAILSGKINNKWLEDKNVVALVSGGNVDLTRVSGVIEHGLNIADTSKGVVG
What is the function of this protein?
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction.  The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate).  Both intermediates are unstable and short-lived.  The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia.  In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
What are the official names of this protein?
L-threonine dehydratase catabolic TdcB, Threonine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: SECA_BUCAT
Sequence: MLIQFLTKIFSNHNNRILKKFKKIVLSVNKLEKNFEKLSDKELQAQTELFRLRLRNGETLDDILPEAFALVREASKRVFSMRHFDVQILGGIALNKQCIAEMRTGEGKTLTSTLPAYLNALNGKGVHIVTMNDYLARRDAEKNTPLFEFLGLTVGLNLSEMSFFSKRKAYLSDITYGTNNEYGFDYLRDNMVFSPEERVQRKLNYALVDEVDSILIDEARTPLIISGPSEDSSELYKEINKIVPFLNSQKKEDSDIFCGTGDFSIDEKSKQIYLTERGLIKVEKILFDKKLMNTGESLYSSNNIILMHHVLSALRAHKLFVRNVDYLVKDNSVIIVDEHTGRTMPGRRWSDGLHQAIEAKENVSIKNENQTLASITFQNYFRLYEKIAGMTGTAETESFEFNSIYNLDTIVIPTNRKMIRKDFPDLVYMTEKEKINAIIQDIQKCIKLNQPVLVGTVSIEKSEIISKELLKLNINHNVLNAKFHAKEAEIIAQAGKPGSITIATNMAGRGTDIVLGGNLEVELNKYKNITSRKIEEIKKKWQSEHDLVVSAGGLHIIGTERHESRRIDNQLRGRSGRQGDTGSSRFYLSMEDSLMRIFASDKIVHMMKKLGLAFNEAIEHSWVTKAIENAQKKVENRNFDIRKQLLEYDDVINEQRSAIYSQRNKLIDARDIKLMIYDIFKDVLKKNIILYIPKNTFHDKWNITDLKDKLNIDFYLNAPILDWINIEPNLTDKKIIKRIIDFARINYKNKEILIGSNNMRIIEKIIMLQTLDSLWKEHLAAVDYLRQGIHLRGYAQKDPKQEYKRESFNMFSSMLELLKFEVVSFLSRINSSYAKKYIDLNKHLVITHNNTMKISRNSPCLCGSGKKYKYCHGSL
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PCP_PSEFS
Sequence: MRIVLLTGFEPFDQDPVNPSWEAVRQLEGVQLADDVQIIARRLPCAFATAGARLAQLIDELHPEMVIATGLGPGRSDISIERVAINVNDARIPDNLGEQPIDTAVAPDGPAAYFTTLPIKAMVRAVRGAGIAASVSQTAGTFVCNQVFYLLQHALAATAVRSGFIHVPYLPEQVTGSQRPSMALETMVAGLHAAVLAAWQTPVDAKEAGGQVS
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_HALH5
Sequence: MAIKRRKVSVIGAGFTGATTALMVAQKELGDVVLVDIPQMEGPTKGKALDMLESTPVQGVDVNITGTSSYEYTKDSDVVVITAGIARKPGMSRDDLVSTNAGIMKAVTKEVVKHSPNAYIIVLTNPADAMTYTVYKESGFPKNRVIGQSGVLDTARFRTFVAQELNLSVEDITGFVLGGHGDDMVPLIRYSYAGGIPLEKLLPQERIDAIVERTRKGGGEIVGLLGNGSAYYAPAASLAEMVEAILKDKKRVLPTIAYLEGEYGYEDIYVGVPTILGGDGIEKVIELDLTDEEKATFAKSIESVRNVMSALPKE
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: NUON_SALG2
Sequence: MTITPQHLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGAMDVTPLMRVDGFAMLYTGLVQVASLATCTFAYPWLEGYNDNQEEFYLLVLIASLGGILLANANHLAALFLGIELISLPLFGLIGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGNLSFEALGKSLGDGMLHEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVSTFLATASKIAIFGVVMRLFLYAPVGDSEAVRVVLGIIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQSGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPFRGPDADSLYSYRGLFWHRPVLAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQASLWWLVAAVVVGSAIGLYYYLRVAVSLYLHAPQQPGRDAPTNWQYSAGGIVVLISALLVLVLGVWPQPLISLVQLAMPLM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HBEAG_HBVH3
Sequence: MQLFHLCLIIFCSCPTVQASKLCLGWLWGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYRDALESPEHCTPNHTALRQAILCWGELMTLASWVGNNLEDPAARDLVVNYVNTNMGLKIRQLLWFHISCLTFGRDTVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRQRGRAPRRRTPSPRRRRSQSPRRRRSQSPASQC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: CS044_RAT
Sequence: MASTRRPFGPPHGAFDFRDMFFDSSKMEEIRNVQARSLGQMAPGQSRILKRNQTMDEKYLLPKEEALAGTGVRLSLRPPTISSKSRASEALRKLAQIETKILKRRQVPTAWSGMESDSTASERSLPQRTDTTSVSSQYPLRTFQKQVCKTSVVGDDGQSGKGSRFLKKKELPAEARSPVLAAETEKQVLLPTQREPARKYDAPDSDEEEMKVLLGSLMESSGEKERNGNQELPGTRSDLGKVFLDLTPDQPGVLCLLSADQSSLKSTSVSLRAQSLQTRSGGDPASLTTSPSILRDDFSRSASSKRECIKLASSPSRMETESSEEPVSEAAADSLHDFRINILSIDDLVLADGYKSDGEQKGVTTVVEDEEDLTTEHEISEHPGASSTAAVWSHSMSSARSMETPTALSVSPVYSEDFEQFSGPLALEESLDRTLDTLSKFSSGEQTDTVSRQPLSRTEWGRGVTRVVKETAVQTLDPAFAYQWTKAGGMAAIGPTLGGGYVDPVPIASHIISADAIEALTAYSPAVLALNDMLKQQLSLTQQFIEASHHLHHSLLRSLDEDSFHYHTLEEAKEYIRCHRPAPLTMEAALQEVRKELEVHLDINDSHVEASKAAALPAEPIDGL
What are the official names of this protein?
Uncharacterized protein C19orf44 homolog.
Protein: RL21_BUCAP
Sequence: MYAVFMSGGKQYRVKKNQIIQLEKLNNSPGSIIEFDKILMISAKKEVKIGEPFLKGTKIKAHVENHGRLKKIKIIKFNRRKHYKKKQGHRQYFTNVKILDINNFNGK
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: TRXF_MESCR
Sequence: MAMQLSLSHQSWAKSLASPITSFDPARSPPKRVELGPNCLNGGATAGKLMREKVGERMRMSGRSCCVKASLETAVGAESETLVGKVTEVDKDTFWPIANGAGDKPVVLDMYTQWCGPCKVMAPKYQELAEKLLDVVFLKLDCNQENKPLAKELGIRVVPTFKILKGGKIVDEVTGAKFDKLVAAIEAARSS
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide.  The F form is known to activate a number of enzymes of the photosynthetic carbon cycle (By similarity).
What are the official names of this protein?
Thioredoxin F-type, chloroplastic, Trx-F.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant F-type subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MALK_PHOPR
Sequence: MTSVTLRNVCKAYGDNLISKNVDLEIAEGEFVVFVGPSGCGKSTLLRCIAGLEDITSGDLYFGKERMNDVPPSDRGVGMVFQSYALYPHLNLFDNMSFGMKLAKADKSEIKKRVNNAADILQLGHLLERQPKSLSGGQRQRVAIGRTIVSQPNVFLLDEPLSNLDAALRVQMRIEIAKLHKQLGCTMIYVTHDQVEAMTMAEKIVVLDGGYVSQVGKPLELYHYPQNRFVAGFIGSPKMNFMSVFIEQVEDERVMVQTADGKAFWIPVDGTTVTKGDRMSLGIRPEHLVSAEEGDTSIEGTVQVVEKLGYETQVYIHLDHVDADFIYRRPDTLQVEAGDSFKVGIPAHRCHLFHSDGRACRRLYQEAGI
What is the function of this protein?
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Maltose/maltodextrin import ATP-binding protein MalK.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y194_GEOMG
Sequence: MKILYCDCFAGIAGDMTVAALLDLGVPFEVVEGAVKQLPLPHSSYSLAVERTSRKGIAAARFVVHVEEHQPHRHYADIAAMIEESTLAEGVKEKAQRIFFRLAEAEAKVHGVEIGRVHFHEVGAVDSIVDIVGTAAALEWLGIDAVHAAPLPLGSGFVETAHGRLPVPAPATAELLRGLPIHGEAGSGERVTPTGAAILAALATGFGRAPAMTVTGVGCGAGTKDFDDIPNVMRLFMGEAEGGLLRDEVCIIETHIDDMNPEILGHVLERLMEAGALDAAFSPLQMKKNRPAVKLTVIARPGQRDELAALVLRETSAIGVRFYPASRLKLSREKEERPTSLGPVTVKVIRDGGRVVRVTPEYDACRRIAAEREMSLLEVYRIVEREAGEP
What are the official names of this protein?
Putative nickel insertion protein.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: RR8_CALFG
Sequence: MGRDTIADILTSIRNANMDKKGTVRIASTNITENIVKILLREGFIENVRKHQENNKYFLVSTLQHRRNRKGRYRTILKRISRPGLRIYSNYQRIPRILGGMGIVILSTSQGIMTDREARLEGIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ALL4_CARMA
Sequence: DPYAFGL
What is the function of this protein?
May act as a neurotransmitter or neuromodulator.
What are the official names of this protein?
Carcinustatin-4.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: COX2_MAXBA
Sequence: MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLYYGQCSEICGSNHSFMPIVLEMVPLKNFENWSASMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YIDD_RHOPT
Sequence: MQLPSRGTDWIAPVLRLPRNAGRGLIWLYRHTLSPLVGYNCRHYPTCSMYGDEAIRKFGLWAGGWMTLARLLRCQPWGTSGIDLVPQTAPSRARWYLPWRYARWRGVNAPPPDVAEPCGCGSHSQLTPH
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YCIB_BURMS
Sequence: MKFLFDLFPIILFFAAFKLWGIFTATAVAIAATLAQVAWVAFRHRKVDTMLWVSLGVIVVFGGATLVLHDEKFIQWKPTVLYWLFAVGLVAARYAFGKNLIEKMMGKQLTLPEPVWDKLNLAWAAFFAALGVTNLYVVRNFTESQWVNFKLFGTTGAIVVFVILQSLWLAKYLKEE
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TYSY_IIV6
Sequence: MDINNEEKQYLNLLEKVLFQGEDRDDRTGIGTKNVFGEQLKFNLRTSFPLLTTKKVFWKGVVEELLWFISGSTDVSVLNQKGVKIWNKNAESFYTQQNLFKKNDLGPIYGFQWRHYGENYIGCDNKYGGIDQLKNIITTIQNEPWDRRMILLAWNPKDNSKMALPPCHCIAHFDVSSKINGKRELSCHLFQRSADMGLGVPFNIASYALLTHIIAHVSSTNTELIVPGDFVHTLSNVHIYKNHIKALTEQISRIPRKFPTLEIINKNKNIDAFSSKDFVLKDYNPYPALEMEMAL
What are the official names of this protein?
Probable thymidylate synthase 225R.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family.
Protein: PAND_HYDCU
Sequence: MQITLLKSKLHRVTTTHSELDYEGSCAIDGHFLEVAGIREYEQIQIYNVNNGNRFTTYAIRAEENTGIISVNGAAAHKAAPGDLLIIATYASMDEKEAEEFKPIMVYFDEKNQITHTRNTIPKQMQQLA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIXK_AZOC5
Sequence: MSIAASVIAHIAPVPAQAYAHPMPSNRWSEMARGVAADESARPAQVVAALGTPAVFARNSEIFGDDQVAENVYVVVSGVVRICKLMGDGRRQIEAFCLPGDAFGWETGERYRFSAEAVSECRLVRVKRSVLFARAGSDPELACALWALSFAELQRAQEHLLLLGRKTAQERVGSFLLDLARRSGTTNASHVTEVTLAMSRQDIADFLGLTIETVSRTLTYLEEQGTISLPSSRRVLLRDRSALRRLDS
What is the function of this protein?
FixK is a protein that regulates nitrogen fixation genes both positively and negatively.  FixK is a positive regulator of NifA expression.  FixK may bind DNA at the FNR consensus binding site.
What are the official names of this protein?
Nitrogen fixation regulation protein FixK.
Protein: MTND2_ORYSJ
Sequence: MENQFQDGKEEVIEAWYMDDSEEDQRLPHHREPKEFIPLSKLSELGILSWRLNADDWENDENLKKIREARGYSYMDICDVCPEKLPNYEAKLKNFFEEHLHTDEEIRYCLEGSGYFDVRDQNDQWIRVAVKKGGMIVLPAGMYHRFTLDSDNYIKAMRLFVGEPVWTPYNRPHDHLPARKEYVEKIINRGGTQAVEAR
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase 2, Acireductone dioxygenase (Fe(2+)-requiring) 2, ARD' 2, Fe-ARD 2, Acireductone dioxygenase (Ni(2+)-requiring) 2, ARD 2, Ni-ARD 2, Submergence-induced protein 2A.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NOMO2_HUMAN
Sequence: MLVGQGAGLLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGFSVCGRISIIRFPDTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTFPLTVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGRENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQEREKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSMEAVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGLFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSENLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKHITLIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVGALGQAASDNSGPEDAKRQAKKQKTRRTLRLQEEFQLMWCLVPWRGTLGIHLFSSLPFASEILLETTATCIHY
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522, PubMed:32820719).  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522).
What are the official names of this protein?
BOS complex subunit NOMO2, Nodal modulator 2, pM5 protein 2.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RTC1_CLAL4
Sequence: MVSSLARYAFNIYGDTRPRERPRRLEYPCERELTCLSQLQRPGQPPVVILGGKNCLRMLALNADNTAVVADSSIVDSARTPQKLFSVNTLKCTSDLVACGLANGTVQVYQVTSGGKNRLAYKLQDHKRVVNSLDFVDDSVLVSGSQDGTVKVWDLRTFSPRPVMQLAASHHSDPVRSCQASAHCRVRGKTTVLSVHDSGALCKFDLRATAGVGAGVGAGAGAGALLPERKWTFHSGPALSLHIHPDAEYVLTGGRDRKICVWHYGEAGSHSVAPLSIVNTYGPVMKVRWCTVAAQDPVEPTLDLPDAPDPSCLYNYDFACSYLNDDATISVYNLRRRYIPKAVVASPMRKPVQNFVWVASRTDRRLFSISKANVLVAHDLDVNDVDITRPLDNMPAVATAWRPGYANVSIVSQHKNDFELGDPVADSRDTSFDDTRDDLSHSRSTPPKERPPIVRQSTQFTVASLKSQSPVLHQRGMDSSVRDSSARAMDLSGRGLDLPPPVRPSLPRNPSQSTQGSQSSGAAHSKSLPHAPSPYVAALSVPIPLADDTVFDILAAEYHISVPDGFSLLDVCQMNARVAASVSRYRDCEIWRMLGVSLEQEFEEHQFDDPRFDGQFEDQHTDPQNASGSQHSEKDIDTKSVSSYLGNFVGSFNSNSTSTTNYGGPHRSDSATSMNKALFGSKEREGKEGKDIKHGKREKEIEQGLESPKELNPLSTRRKDSDSKANNADSSALDKPGDKSLDRSALDRSAPTSFRNKSLLQTSDGETPKDNNLSDEIHAYEPRNNLSTKVSLSTMSSQKSKAIDIKAPRRYSNNAMSASMSPEIFASSESPLKHIAKLSPSRSQTGHSWSIPSSSHDLDDENMPASVSGSLASSGYMGGPDSRSGITGTSFHSNPRSHPSFSSHRSSLTSGRSSFVTNRSGFYSSQVQPAPQLLEKVEEFSISSAEPKTSELTKAMRKKKFSYEELESSEANEKPWSLINLLEKAVIYARDQGDLVMCCTLILLFHDLFKKIFSNRILSDNACLECLALYVDTLRGKCLFTTAVNVVKEAPSSLNYKLAVYASKDVDMRYYCCWCEKLLVNETSKAKFGPNSENFGYWYCDSCSRRQSNCIYCGEPCRGLTVVVSLNCGHRGHFGCLQEWFLDEQSTGCPGGCEYVMD
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RTC1 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: BLO9_KLEPN
Sequence: MKKILLLHMLVFVSATLPISSVASDEVETLKCTIIADAITGNTLYETGECARRVSPCSSFKLPLAIMGFDSGILQSPKSPTWELKPEYNPSPRDRTYKQVYPALWQSDSVVWFSQQLTSRLGVDRFTEYVKKFEYGNQDVSGDSGKHNGLTQSWLMSSLTISPKEQIQFLLRFVAHKLPVSEAAYDMAYATIPQYQAAEGWAVHGKSGSGWLRDNNGKINESRPQGWFVGWAEKNGRQVVFARLEIGKEKSDIPGGSKAREDILVELPVLMGNK
What is the function of this protein?
Oxacillin-hydrolyzing beta-lactamase.  Confers resistance to beta-lactam antibiotics but at a significantly lower level than the TEM bla gene product.
What are the official names of this protein?
Beta-lactamase OXA-9, Oxacillinase, Penicillinase.
What is the protein family that this protein belongs to?
Belongs to the class-D beta-lactamase family.
Protein: RL31B_ALISL
Sequence: MKEGIHPTYRKVLFHDTSVNKYFLIGSTLQTDRTMKWEDGKEYPYMTLDISSESHPFYTGEQRVVSTEGRVANFNRRFGALKGKV
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: NHAA2_ALIB4
Sequence: MKNSLFLIKDFISKETLSGLILFVVTVLAVTIANSDFGSYYFELFSTQLGINFGQLNASMSLLHWINDVLMAIFFLVVGLEIKREMLIGELSSVKKASFPIIAAIGGMIVPAILYISLNPDHITGFGVPMATDIAFALGILMLLGNKVNPAIKLFLVTLAVVDDLGAIVVVAIFYTNELHFEYFLYAFAVYSIIWFLNYKNVQKLTPYIILGVFLWIFIHKTGIHSTIAGVLLAFAIPLNKKADLEESVENLSVDNPLVKLEHALHNFSAFIIMPLFAFANAGVIIDFSNVIEHQLIVLGVALGLIIGKPIGIFSFTYLATKLKISVKPENVTWNDIFAVGFLGGIGFTMSIFISHLAFSDQTIVGAVKLGIFASSVIAAIIGSVLLILKAKKVEP
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 2, Sodium/proton antiporter NhaA 2.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.