PharMolix/UniProtQA huggingface dataset:
Protein: KGUA_HELHP
Sequence: MSKGAVLIISGPSGCGKSTLTKSLIESIPNVYFSISTTTRPMREGETDGVHYHFVSKEHFLQDIHNNVFLEWAEVHTNFYGTSLKPVQQALEQDKIVLFDVDVQGHHSIKEYFGDFAKSVFITTKNKDILRERLISRQTDDLQTIEFRLIQAHNEMQHIHNFDYLIINDDITTAKEAMVAIARSLKYQQIERLSKIIQKW
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_KLEP3
Sequence: MEWSLSQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVASPGVPPLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTARRPLPSGDVTEKEARTLFIVLVLLSFLLVLTLNTMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFSAVSESLPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGENDRLIIGILQVAVLALMGAVGWLNGLGWEYYWSLFVAAGLFGWQQKLIFNRERDNCFKAFMNNNYVGLVLFLGLAMSYL
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACCD_CARHZ
Sequence: MFDFFRKSKYVTVKPETKQKEIPDGLWQKCPRCGEIIFNKELEKNFKVCPKCGYHFKISAWERIKLLCDENSFVEFGREISGGNPLNFPGYEEKLAEAREKTGLKEAVVTGLGKINGREVVLAIMDPNFIMASMGTAVGEKICLAMEKALEKKLPLVVFTASGGARMQEGIFSLMQMAKTVQLVNRLNAEKIFYLVVMTDPTTGGVSASFAALGDIILAEPGALIGFAGPRVIEQTIRQKLPEGFQRAEFLEQHGFIDAVVSREQQKEVITKLLAWHSQK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_NITMU
Sequence: MDKAIYPGTFDPITRGHEDLVRRASGLFREVVVAVAASSGKKPFFTQEERVAMVRQVLTDYPNVKVMPFSGLLMEFAQQQQARVIVRGLRAVSDFEYEFQMAGMNRTLYPDVETLFLTPSEQYMFISATIVREIALFGGNIEKFVHPLISTQLGMKIASKDKSSR
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_PSELT
Sequence: MNGNRPNYISLIFAALVILSLFWLVRSFYFDTSAPSKMSFSDFIQMAYEEPTRIAEVVVRDDGILRVTTKRGEYYEIYAPWFMQDSETIKVLSEKGVRVTGEKGVSSSFWVNVIGNVIFIGFLLFMFFFMMRTISGRNNQAFTFTKSRAQMNRPGQARVTFKDVAGVDEAVEELKETVLFLKDPGRFSKIGARMPKGILLVGPPGTGKTLLARAVAGEANVPFFHISGSDFVELFVGVGAARVRDLFNQAKANAPCIVFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFDVRQGIVVMAATNRPDILDPALLRPGRFDKKVVLDTPDVRGREEILKIHARNKPIAEDVDIRVLAQRTTGFVGADLENLVNEAALLAARNGRDKIKMEDFEEAIDRVIAGPARKSRVISPREKRIVAYHEVGHAIVSSLLPNADPVHRISIIPRGYRALGYTLQLPAEDRYLVTKQELLDQITGLLGGRAAEELIFQEVTTGAASDIERATELARRMVCQFGMSDKLGPLSWGKTEQEIFLGKELTRMRNYSEEVASEIDEEVRKIVTESYDRAKEILTKYHKQLDELVELLLEREVLEGEELRKILKTELGEEMVNHDKLRAAAGSEQDS
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: ASSY_VIBCH
Sequence: MSKVQVKKVVVAYSGGLDTSVIIPWLKENYDCEVVAFVADVGQGDEELKGVEAKALSSGASECYIVDLKEEFVKEYIYPTLKTGAYYEGKYLLGTSMARPVIAKAQVEIARKVGADALAHGCTGKGNDQVRFEGAFAALAPDLHVIAPWREWDLRSREACLDYLAERNIPCAASLTKIYSRDANAWHVSTEGGVLESTWNAPNEDCWVWTVDPEQAPNEAEYVTLQVAHGEVVAVDGEAMTPYNALLYLNQKGAKHGVGRIDIVENRLVGMKSRGCYETPGGTIIMEALRAVEQLVLDKTSFEFREELGIKASHLVYDGRWFTPLRQAVFAAADELAKDVNGEVVIKLYKGQAVATQKRSANSLYSEDFATFGADEVYDHSHAGGFIRLYSLSSRIRALSQNKQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I49A1
Sequence: MNPNQKLFALSGVAIALSVMNLLIGISNVGLNVSLHLKEKGTKQEENLTCTTITQNNTTVVENTYVNNTTIITKEPDLKAPSYLLLNKSLCSVEGWVVIAKDNAIRFGESEQIIVTREPYVSCDPSGCKMYALHQGTTIRNKHSNGTIHDRTAFRGLISTPLGTPPTVSNSDFICVGWSSTSCHDGVGRMTICIQGNNDNATATVYYNRRLTTTIKPWARNILRTQESECVCHNGTCAVVMTDGSASSQAYTKVMYFHKGLVIKEEPLKGSAKHIEECSCYGHNQKITCVCRDNWQGANRPIIEIDMNTLEHTSRYVCTGILTDTSRPGDKPSGDCSNPITGSPSAPGVKGFGFLNGDNTWLGRTISPRSRSGFEMLKIPNAGTDPNSRIAERQEIVDNNNWSGYSGSFIDYWDDDNECYNPCFYVELIRGRPEEAKYVWWTSNSLIALCGSPFPVGSGSFPDGAQIQYFS
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: QUEC_STAA1
Sequence: MESVLNNEKAIVVFSGGQDSTTCLFYAKKHFKEVELVTFNYGQRHDTEIEVAKQIAQDQGMKHHVLDMSLLSQLTPNALTQHDMEITNNEDGIPNTFVPARNLLFLSFAGALAYQIGAKHIITGVCETDFSGYPDCRDSFIKSMNVTLSLAMDKDFVIHTPLMWLNKAETWKLSDELEVLDYIRTKTLTCYNGIIGDGCGECPACHLRQRGLNQYLESKGAL
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: NHP2_PONAB
Sequence: MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHDEYQEAYDECLEEVQSLPLPL
What is the function of this protein?
Required for ribosome biogenesis and telomere maintenance.  Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs.  May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit 2, Nucleolar protein family A member 2, snoRNP protein NHP2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Protein: POLG_SOUV3
Sequence: MMMASKDVVATNVASNNNANNTSATSRFLSRFKGLGGGASPPSPIKIKSTEMALGLIGRTTPEPTGTAGPPPKQQRDRPPRTQEEVQYGMGWSDRPIDQNVKSWEELDTTVKEEILDNHKEWFDAGGLGPCTMPPTYERVKDDSPPGEQVKWSARDGVNIGVERLTTVSGPEWNLCPLPPIDLRNMEPASEPTIGDMIEFYEGHIYHYSIYIGQGKTVGVHSPQAAFSVARVTIQPIAAWWRVCYIPQPKHRLSYDQLKELENEPWPYAAITNNCFEFCCQVMNLEDTWLQRRLVTSGRFHHPTQSWSQQTPEFQQDSKLELVRDAILAAVNGLVSQPFKNFLGKLKPLNVLNILSNCDWTFMGVVEMVILLLELFGVFWNPPDVSNFIASLLPDFHLQGPEDLARDLVPVILGGIGLAIGFTRDKVTKVMKSAVDGLRAATQLGQYGLEIFSLLKKYFFGGDQTERTLKGIEAAVIDMEVLSSTSVTQLVRDKQAAKAYMNILDNEEEKARKLSAKNADPHVISSTNALISRISMARSALAKAQAEMTSRMRPVVIMMCGPPGIGKTKAAEHLAKRLANEIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMTKILDDCNKLQAIADSAPLTLNCDRIENKGMQFVSDAIVITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPEVEQIRRVSPGDTSALKDCFKLDFSHLKMELAPQGGFDNQGNTPFGKGTMKPTTINRLLIQAVALTMERQDEFQLQGKMYDFDDDRVSAFTTMARDNGLGILSMAGLGKKLRGVTTMEGLKNALKGYKISACTIKWQAKVYSLESDGNSVNIKEERNILTQQQQSVCTASVALTRLRAARAVAYASCIQSAITSILQIAGSALVVNRAVKRMFGTRTATLSLEGPPREHKCRVHMAKAAGKGPIGHDDVVEKYGLCETEEDEEVAHTEIPSATMEGKNKGKNKKGRGRRNNYNAFSRRGLNDEEYEEYKKIREEKGGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGETEMEIRHRVFYKSKSRKHHQEERRQLGLVTGSDIRKRKPIDWTPPKSAWADDEREVDYNEKISFEAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVIPTSAKEFFGEPLTSIAIHRAGEFTLFRFSKKIRPDLTGMILEEGCPEGTVCSVLIKRDSGELLPLAVRMGAIASMRIQGRLVHGQSGMLLTGANAKGMDLGTIPGDCGAPYVYKRANDWVVCGVHAAATKSGNTVVCAVQASEGETTLEGGDKGHYAGHEIIKHGCGPALSTKTKFWKSSPEPLPPGVYEPAYLGGRDPRVTVGPSLQQVLRDQLKPFAEPRGRMPEPGLLEAAVETVTSSLEQVMDTPVPWSYSDACQSLDKTTSSGFPYHRRKNDDWNGTTFVRELGEQAAHANNMYEQAKSMKPMYTGALKDELVKPEKVYQKVKKRLLWGADLGTVVRAARAFGPFCDAIKSHTIKLPIKVGMNSIEDGPLIYAEHSKYKYHFDADYTAWDSTQNRQIMTESFSIMCRLTASPELASVVAQDLLAPSEMDVGDYVIRVKEGLPSGFPCTSQVNSINHWLITLCALSEVTGLSPDVIQSMSYFSFYGDDEIVSTDIEFDPAKLTQVLREYGLRPTRPDKSEGPIIVRKSVDGLVFLRRTISRDAAGFQGRLDRASIERQIYWTRGPNHSDPFETLVPHQQRKVQLISLLGEASLHGEKFYRKISSKVIQEIKTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRNLLPEFVNDDGV
What is the function of this protein?
RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals.  Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA.  This sgRNA codes for structural proteins.  Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
What are the official names of this protein?
Genome polyprotein.
Protein: RLMN_YERPY
Sequence: MSEQLLTASTSIDAAPLSDNTVQTTAPATSKINLLDLNRQQMREFFAEMGEKPFRADQVMKWMYHYCYDDFEQMTDINKGLRAKLQRVAEIRAPEVAEEQRSVDGTIKWAIKVGDQQVETVYIPEADRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIIGSLKSTGTRPITNVVMMGMGEPLLNLNNVVPAMDIMMDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPTDDIRDEIVPINRKYNIETFLAAVRRYLDKSKANGGRVTVEYVMLDHINDSTEQAHQLAECLKDTPCKINLIPWNPFPGAPYGRSSNSRVDRFSKVLMEYGFTTIVRKTRGDDIDAACGQLAGEVIDRTKRTLKKKMAGEPIAIKTV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB2_SULIY
Sequence: MEELPATAIGLKVNDGIVLASERRLSYGGYVLSKQAKKVHKIGKFLMAGAGIYGDLQTLTRIMNVEIKYYEISTGKPISVHAAAKLLSVILYQYKVMPFISEILFGGVDEKGPQLYVLDPIGSLIEDNYAAVGSGARIAIGVLESEYDPNMNLDIAAQLITKAIKASIERDITSGDGIDLAIMDKKGNYENKFIPY
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 2, 20S proteasome beta subunit 2, Proteasome core protein PsmB 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_GEOMG
Sequence: MDKLIIKGGKKLTGDVSVSGSKNAALPVFISTILAPGLNEIRNVPFLRDINTTIKVLESLGAVVEGNGNIVKIDTTHVNDVEATYDLVKTMRASVLVLGPLLARHGRARVSLPGGCAIGARPINLHLKGLAALGADIRLEHGYVEAKAKKLKGARINFDIATVGGTEQLMMAAALAKGETILENAAREPEIIDLADILNRMGARIDGAGTDTIRIIGVKELAPVVHDVMPDRIEAGTFMVAAAITGGDIKIHNMKLEHLDALVFKLQDAGVEIINRDNVVRVKGPRRPRAINIKTRPYPGFPTDMQAQFMALMCVADGASVISENIFENRFMHVSELLRFGADITIEGNTATVKGVKKLSGAPVMATDLRASASLILAGLAADNTTEISRIYHLDRGYDSIEKKLAGLGADIKRVKE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM147_MOUSE
Sequence: MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLFSLGSWTALLARAVVTGLLALSTLALYVAVVNVHS
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes.  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.  Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane.  Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity.  Regulates LBR localization to the nucleus inner membrane.
What are the official names of this protein?
BOS complex subunit TMEM147, Transmembrane protein 147.
What is the protein family that this protein belongs to?
Belongs to the TMEM147 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: S35B4_PONAB
Sequence: MRPALAVGLVFAGCCSNVIFLELLARKHPGCGNIVTFAQFLFIAVEGFLFEADLGRKPPAIPIRYYAIMVTMFFTVSVVNNYALNLNIAMPLHMIFRSGSLIANMILGIIILKKRYSIFKYTSIALVSVGIFICTFMSAKQVTSQSSLSENDGFQAFVWWLLGIGALTFALLMSARMGLFQETLYKRFGKHSKEALFYNHALPLPGFVFLASDIYDHAVLFNKSELYEIPVIGVTLPIMWFYLLMNIITQYVCIRGVFILTTECASLTVTLVVTLRKFVSLIFSILYFQNPFTLWHWLGTLFVFIGTLMYTEVWNNLGTTKSEPQKDSKKN
What is the function of this protein?
Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar.  May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics.
What are the official names of this protein?
Nucleotide sugar transporter SLC35B4, Solute carrier family 35 member B4, UDP-xylose and UDP-N-acetylglucosamine transporter.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: RL18_PARP8
Sequence: MDKTQSRLRRARQTRIKIAELQVARLAVHRTNTHIYAQVFSPCGTKVLASASTLEAEVRAQLADKSGKGGNVAAATLIGKRIAEKAKAAGIESVAFDRSGFRYHGRVKALADAAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PDXB_SHEAM
Sequence: MKIIADENMPYVDVLFGELGEIEYVNGRTLAPEQLADADVLLVRSVTQVNEALLCQNQQLKFVGSATIGTDHVDTAYLKSRGIPFTNAPGCNATAVGEYAFIAMLELAQRYRQPLKDKKVAVIGAGNTGTATARCLEAYGVEHRLCDPVLAAQGDNRQFYELDELIAWADVISLHVPITKGGDHPTWYLFDQQRLEALKTGAWLLNCCRGEVIDNRALIEVKQRRVDIKLVLDVWEGEPSPMLALVPLVDIATPHIAGYSLEGKARGTFMLYEALCRVMGKTGENSFHSLLPPFFLGSMQVRELGDERALLTLCRTVYDLRDDDIHFRQSGTDRLGFDKMRKNHRHRREFSALKLENAKGSEVNWLSFLGFSNVG
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA_ACIBC
Sequence: MYAPVESNEGFNFKPELPTSSAYYRLLKKLRRQVGHAIRDFNMIEDGDKVMVCVSGGKDSYTLLDILLQFKRIAPINFDIVAVNLDQKQPGFPEDVLPRYMEENNIPYYILEKDTYSITKRLTPEGKTYCAVCSRLRRGSLYGFAQEIGATKVALGHHRDDIIATFFLNLFHGGSLKAMPPKLLSSDKKNILIRPLAYVEEKDIIKYAELRKFPIIPCNLCGSQENLQRAMINEMLREWDKQYPKRLHSIFGALQNVSPSQLADRDLFDFEVLDSQRELDFKDPEELKKRLDVVNLSFAAE
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNC3_NOSS1
Sequence: MMIQLECLSVTYPGGVQALQAVSLNFNPGEFTVILGASGSGKSTLLRCLNGLIQPTAGTITIEGYRQINDPKVLHQHRQRTGMIFQQHQLIARQTALQNVLTGRLAYHSTVRSFFPLPKADKYIALECLDRVGLLSKALARVDNLSGGQQQRVGIARALAQQPRLMLADEPVASLDPASSHKVISFLRQICQEDGIAAIMSLHQVDLAKAYADRIVGISQGRIVFDGSAADIEECELNRIYGNAENIHFDDIPSNQYPIASN
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RT24A_XENLA
Sequence: MAAPVMSALGRLQGLIRTERSLLTHVQSRCIQTTSVCLKNRAARVRVGKGDKPVTYEAAHPPHYIAHRKGWLSQHTGNLDGEGGAAERTIEDVFIRRFIFGTFHGCLANEIVIKRRANLLIICAIFIRKMPTQKFYFLIGYTETLLSFLYKCPVKLEVQTVEEKVIYKYL
What are the official names of this protein?
28S ribosomal protein S24-A, mitochondrial, MRP-S24-A, S24mt-A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MKKS_MOUSE
Sequence: MSRLEAKKPSLCKTEPLTSEKVRSTLSVLKGVIASCYGPSGRLKQLHNGLGGCVYTTSQSSALLRNLSVTHPVLKILTSSVQNHVSCFSDCGLFTAILCCNLIENIQRLDLTPATAIKLNKYLLSLCTSYLKSEACSCRIPVDFRSTHTFLSLVHSILTSKPACMLTRKETDHIGALILKAFLLTIPESTEERMVLGKSIIVPLKGQRVTDSTVLPGLLIEASEVQLRRLLPTQKASGLRVALFCTSLSGDFSNAGEGVVVAHYQVSLENAVLEQLLNLGRRLVTDHVDLVLCQKVIHPSLKQFFSERHVMAIDRVGVTLMESLSKVTGATPIGSLNPIVSTTYGSVKDVCSARFGSKHFFHLLPNEATVCTLLLCSRNDTAWEELKLTCQTAMHVLQLTIKEPWVLLGGGCTETHLAAYVRHKVHHEAEAIVRDDGCTQAKLHVAAEAFCSALESVAGSLEHDGGEILIDTKYGHLWSCQADSASVGNWSDTLSRCGCGLYNSQEELSWSVLRSTYHPFAPQTCLPQAALGSASNLTVDCFTAKLSGLQVAVETANLILDLSYVIEDKN
What is the function of this protein?
Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (By similarity).  Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:28753627).  May play a role in protein processing in limb, cardiac and reproductive system development.  May play a role in cytokinesis (By similarity).
What are the official names of this protein?
Molecular chaperone MKKS, McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin, Protein Bbs6 homolog.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Nucleus. Note=The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome.
Protein: DDAH_MYCTU
Sequence: MENTQRPSFDCEIRAKYRWFMTDSYVAAARLGSPARRTPRTRRYAMTPPAFFAVAYAINPWMDVTAPVDVQVAQAQWEHLHQTYLRLGHSVDLIEPISGLPDMVYTANGGFIAHDIAVVARFRFPERAGESRAYASWMSSVGYRPVTTRHVNEGQGDLLMVGERVLAGYGFRTDQRAHAEIAAVLGLPVVSLELVDPRFYHLDTALAVLDDHTIAYYPPAFSTAAQEQLSALFPDAIVVGSADAFVFGLNAVSDGLNVVLPVAAMGFAAQLRAAGFEPVGVDLSELLKGGGSVKCCTLEIHP
What is the function of this protein?
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA).
What are the official names of this protein?
N(G),N(G)-dimethylarginine dimethylaminohydrolase, DDAH, Dimethylarginine dimethylaminohydrolase, Dimethylargininase.
What is the protein family that this protein belongs to?
Belongs to the DDAH family.