PharMolix/UniProtQA huggingface dataset:
Protein: CBPYA_EMENI
Sequence: MRVLPATLLVGAATAATPAQQVLGGLQDFGNAVQDAMHENLPKINKPLEAFQEQLKSLYEAREFWEEVANAFPQNLDHNPVFSLPKKHTRRPDSHWDHIVRGADVQSVWVTGENGEKEREIEGKLEAYDLRIKKTDPSSLGIDPDVKQYTGYLDDNENDKHLFYWFFESRNDPKNDPVVLWLNGGPGCSSLTGLFMELGPSSIDENIKPVYNPYAWNSNASVIFLDQPVNVGYSYSGSTVSDTVAAGKDVYALLTLFFKQFPEYAEQDFHIAGESYAGHYIPVFTSEILSHQKRNINLKSVLIGNGLTDGLTQYEYYRPMACGEGGYPAVLDESSCRSMDNALGRCQSMIESCYNSESAWVCVPASIYCNNALLAPYQRTGQNVYDVRGKCEDESNLCYKGMGYVSEYLNKPEVRAAVGAEVDGYDSCNFDINRNFLFHGDWMKPYHRLVPGILEQIPVLIYAGDADFICNWLGNKAWTEALEWPGHKEFAAAPMEDLKIVDNEHTGKKIGQIKTHGNFTFMRLYGGGHMVPMDQPEASLEFFNRWLGGEWF
What is the function of this protein?
Vacuolar carboxypeptidase involved in degradation of small peptides.  Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).
What are the official names of this protein?
Carboxypeptidase Y homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: RPOA_NITWN
Sequence: MTIQKNWQELIRPNKLQVVPGSDPSRFATLIAEPLERGFGQTLGNALRRILLSSLQGAAVQSVHIDGVLHEFSSIAGVREDVTDIVLNIKDIAIRMQGEGPKRMVVKKQGPGTVTAGDIQTVGDVVVLNPDLQICTLDDGAEIRMEFTVASGKGYVAAERNRPEDAPIGLIPVDSLYSPVRKVSYKVENTREGQILDYDKLTMTIETNGGVTPEDAVAFAARILQDQLNVFVNFEEPRKEVTTEIIPDLAFNPAFLKKVDELELSVRSANCLKNDNIVYIGDLVQKSEAEMLRTPNFGRKSLNEIKEVLAQMGLHLGMEVPGWPPENIDELAKRFEDHY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: SMRCD_DROME
Sequence: MSDSTVAASASASASSSAKSSLSDLRQFRINKNASSVVASPSRTERVPGKKRIQVMADSDSDGNDSQTPKKTKLELTVKEKEERYMAAAKISPHFDTMAIQESLSRTNWDVAASVRYLRENCKPKGHNGPLAKSKLKPRSNGISGGNFSDNDHSDDDDVKQSKDQVYDSDDSDSEMSTKMTGQRKKVFQFMNEASLIELQSVKTLSEKKALAIIDVRPFSDWSDLRQKLESIRMSGDLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISNGAGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMRGRFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELVDYYSNNKGEVCSSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDSIFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTTALGLDKDQEEQLNNSLNNSIASPAK
What is the function of this protein?
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization.  Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity).
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog, Enhancer trap locus homolog 1, Etl-1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YL374_MIMIV
Sequence: MTIFYLVFIAVIIIIILYVLYLRPLYSGTSVIKGNTQYKADKLMIIAHPDDELIFGSKELIENPGWKVICITNGSKKSVNKISICYLMGHRSTYRRDEFINMMNLLHCQYEIWDYEDNYFNSNWNLKQLKNQLENLLREKNYKMVLTHNLAGEYGHTQHKTISKLLYDINPPNLYTFYYDSNTINPYLVLIKKLSHVYQSQDKIIKKNYKYIEHQSKIAVKNNSK
What are the official names of this protein?
Uncharacterized protein L374.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CAPSD_HBVA2
Sequence: MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVGNNLQDPASRDLVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRDRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
What is the function of this protein?
Self assembles to form an icosahedral capsid.  Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins.  Entering capsids are transported along microtubules to the nucleus.  Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta.  Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153.  Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm.  Immature capsids get stuck in the basket.  Capsids encapsulate the pre-genomic RNA and the P protein.  Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm.  The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.
What are the official names of this protein?
Capsid protein, Core antigen, Core protein, HBcAg, p21.5.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus core antigen family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: DSBB_SACD2
Sequence: MKITKLPSYRQTALIIFAGCVGLILAALYMQEVLGLHPCPLCITQRIFIIGVGLISLIAAIHNPAALGRKVYGCLATLSGVIGAGVSARHVWLQNLPEDQVPACGPDLAYMFDAFPLLDALKLLFAGDGNCADVVASFLGLSIPGWTFVAFVGLIAISVWQGLRKA
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HELIC_BPT7
Sequence: MDNSHDSDSVFLYHIPCDNCGSSDGNSLFSDGHTFCYVCEKWTAGNEDTKERASKRKPSGGKPMTYNVWNFGESNGRYSALTARGISKETCQKAGYWIAKVDGVMYQVADYRDQNGNIVSQKVRDKDKNFKTTGSHKSDALFGKHLWNGGKKIVVTEGEIDMLTVMELQDCKYPVVSLGHGASAAKKTCAANYEYFDQFEQIILMFDMDEAGRKAVEEAAQVLPAGKVRVAVLPCKDANECHLNGHDREIMEQVWNAGPWIPDGVVSALSLRERIREHLSSEESVGLLFSGCTGINDKTLGARGGEVIMVTSGSGMGKSTFVRQQALQWGTAMGKKVGLAMLEESVEETAEDLIGLHNRVRLRQSDSLKREIIENGKFDQWFDELFGNDTFHLYDSFAEAETDRLLAKLAYMRSGLGCDVIILDHISIVVSASGESDERKMIDNLMTKLKGFAKSTGVVLVVICHLKNPDKGKAHEEGRPVSITDLRGSGALRQLSDTIIALERNQQGDMPNLVLVRILKCRFTGDTGIAGYMEYNKETGWLEPSSYSGEEESHSESTDWSNDTDF
What is the function of this protein?
ATP-dependent DNA helicase and primase essential for viral DNA replication and recombination (PubMed:21606333, PubMed:22977246, PubMed:32009150).  The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead of the leading strand polymerase at the replication fork and generating ssDNA for both leading and lagging strand synthesis (PubMed:21606333, PubMed:22977246, PubMed:32009150).  ATP or dTTP hydrolysis propels each helicase domain to translocate 2 nt per step sequentially along DNA (PubMed:30679383, PubMed:17604719).  Mediates strand transfer when a joint molecule is available and participates in recombinational DNA repair through its role in strand exchange (PubMed:9096333, PubMed:8617248).  Primase activity synthesizes short RNA primers at the sequence 5'-GTC-3' on the lagging strand that the polymerase elongates using dNTPs and providing the primase is still present (PubMed:6454135, PubMed:9139692).
What are the official names of this protein?
DNA helicase/primase, Gene product 4, Gp4.
What is the protein family that this protein belongs to?
Belongs to the Teseptimavirus DNA helicase/primase family.
Protein: MCPS_KLEAK
Sequence: MFNRIKVVTSLLLVLVLFGALQLISGGLFFSSLKSDKENFTVLQTIRQQQLLLSESRVDLLQARNSLNRAGIRYMMDTNKIGSGATIDELLAKAKEELARAERNYTAYEKIPQDPRQDPQATEKLKQQYGILYGALSELIQLLGEGKINAFFDQPTQKYQDDFEQTYNAYLQQNGKLYQIAVDASNSSYSSAIWTLIVVIIVVLAAIVGVWMGIHHILVRPLNRMIEHIKRIASGDLTQPIPVTSRNEIGVLAASLKHMQNELIETVSGVRQGADAIYSGASEIAAGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQASQLALSASETAQKGGKVVANVVETMHDIASSSQKIADITGVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAKEIKALIEDSVNRVDMGSVLVESAGDTMGDIVNAVTRVTDIMGEIASASDEQSRGIDQVGQAVAEMDRVTQQNASLVEESASAAAALEEQASLLTQSVAVFRLKSEGQEEYKAPVSNKTAPAAIATHKKTSASDYQDNWETF
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.  Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.
What are the official names of this protein?
Methyl-accepting chemotaxis serine transducer.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ALLA_PSEE4
Sequence: MRTLMIEPLTKEAFAPFGDVIETDGSDHFMINNGSTMRFHKLATVETAEPEDKAIISIFRADALEMPLTVRMLERHPLGSQAFIPLLGNPFLIVVAPVGDAPVSGLVRAFRSNGRQGVNYHRGVWHHPVLTIEKRDDFLVVDRSGSGNNCDEHYFPEEQMLILNPHQ
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: FRSA_PHOLL
Sequence: MANRNLSESLFKPRQKHQETSTLVKHRDPRLIAGNYSTLDGNSHGSWYRMINRLMWIWREIDPFEIEEVLCRIAMTNAQRSDDNLLDTVIGYRKGNWVFEWSHQAMLWQQRALQAEQIPEASNFWLKAANLYSIAGYPHLKGDELSQQAVILANKAYENAARCSGYQLRKIEFKLKEGGCVTGFLHLPQQLQRPSPTILVCGSLDNLQSDYYRLFRDYLAPLGFAMLTVDMPSIGYSSRLRMTQDTCILHQQIIHQLDEIPWIDHTRIGLFGFRFGANIAVRLAYLESKRIKGVATLGAIVHEWLSSVERQQNSPSMYLDMFASRLGIYNVDEKAFRLELGCYSLKKQGLLGRRCSVPMLAGYWQNDIFSPKEESKLIAMSSMDSQLLAIPTTPVYNSFNKALREISQWLRNKVC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: Y4744_VEREI
Sequence: MEWVDTGSAMQAPDATFADTREARQAIRAGRWRRHTSGLAPAYVQGNLVILPVDLASDFMRFCQSNPKPCPLLAVGQAGDPALPTLGRDIDIRTDVPAYRVYRDGVLVGEVDDLKALWRDDFVAFVLGCSFSFEHGLIEAGIPLRHVDEGKNVAMYRTNIQTVPAGPFHGPMVVSMRPMKAADAIRAVQITARVPQVHGAPVHIGDPALIGIADITQPDFGDAVRIAPDELPVFWACGVTPQAVVMAAKPALCITHSPGYMLITDMLNRDLPFA
What are the official names of this protein?
Putative hydro-lyase Veis_4744.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: GLPG_ECOHS
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CHX24_ARATH
Sequence: MVRHFPINDQSLLPAHFGFWPGNSTTPGEVSNRVFSPKIPVVCRKLHSKQPFGMFKGENAMNYAFSTFLIEAIIIIFFIKVVSIALRPFRQPRIVSEIIGGMMIGPSMFGGIRNFNYYLFPPIANYICANIGLMGFFYFLFLTAAKTDVGAIGKAPRKHKYIAAIGVIVPIICVGSVGMAMRDQMDENLQKPSSIGGVVFALSFTSFPVIYTVLRDMNLLNSEVGKFAMSVALLGDMAGVYVIVIFEAMTHADVGGAYSVFWFLVSVVIFAAFMLLVVRRAFDWIVSQTPEGTLVNQNYIVMILMGVLASCFLTDMFGLSIAVGPIWLGLLVPHGPPLGSTLAVRSETFIYEFLMPFTYALVGQGTNIHFLRDETWRNQLSPLFYMTVVGFITKFLSTAFAALFFKVPARESITLGLMMNLRGQMDLLVYLHWIDKRIVGFPGYTVMVLHTVVVTAVTTPLINFFYDPTRPYRSSKHRTIQHTPQNTEMGLVLAVSDHETLSGLITFLDFAYPTKSSPLSIFAVQLVELAGRATPLFIDHEQRKEEEEEEYEEEEEEPERKQSGRIDQVQSAFKLYEEKRNECVTLRSYTAHAPKRLMYQDICELALGKKTAFILLPYQKERLEDAAPTELRDSGMLSVNADVLEHTPCSVCIYFDKGRLKNAVVRLSMDLQHSTNSIRMRQETYRFVVLFLGGADNREALHLADRMSTNPDVTLTVIRFLSYNHEGEDEREKKLDDGVVTWFWVKNESNERVSYKEVVVKNGAETLAAIQAMNVNDYDLWITGRREGINPKILEGLSTWSEDHQLGVIGDTVAASVFASEGSVLVVQQQVRNQKGGDGFLNGKFDYKRFLSPWSHSHN
What is the function of this protein?
May operate as a cation/H(+) antiporter.
What are the official names of this protein?
Cation/H(+) antiporter 24, Protein CATION/H+ EXCHANGER 24, AtCHX24.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PG099_VACCW
Sequence: MENVPNVYFNPVFIEPTFKHSLLSVYKHRLIVLFEVFVVFILIYVFFRSELNMFFMPKRKIPDPIDRLRRANLACEDDKLMIYGLPWMTTQTSALSINSKPIVYKDCAKLLRSINGSQPVSLNDVLRR
What is the function of this protein?
Component of the entry fusion complex (EFC), which consists of 11 proteins.  During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation.
What are the official names of this protein?
Entry-fusion complex protein OPG094, EFC protein OPG094, Protein F6, Protein L5.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG099 family.
Protein: NANR_SHIFL
Sequence: MGLMNAFDSQTEDSSPAIGRNLRSRPLARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIIGELSGMAKDFLSHPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAFIRSDVDFHRVLAEIPGNPIFMAIHVALLDWLIAARPTVTDQALHEHNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSATWHAFGQTTNKKK
What is the function of this protein?
Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids.
What are the official names of this protein?
HTH-type transcriptional repressor NanR.
What is the protein family that this protein belongs to?
Belongs to the NanR family.
Protein: RS3_SHEFN
Sequence: MGQKVHPNGIRLGITKPWISTWYADKSDYANNLNSDWEVRQYLTEKLKAASVSKIVIERPAKSIRVTIHTARPGIVIGKKGEDVEVLRAYVSKITGTTAQINIAEIRKPELDAKLVADSIAQQLERRVMFRRAMKRAVQNAMRIGAQGIKVQVSGRLGGAEIARAEWYREGRVPLHTLRADIDYSTAESHTQYGVIGIKVWIFKGEVLDGLVPAIEEPKQQPKRKPRGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RECR_FRAT1
Sequence: MTSKIFSPKISAVIESLRKLPTIGKKSSQRLALYLLDKSPETAIAIANSLLDATANIKKCVYCQALTEDDVCNICSNTNRDNTKLCIIESMLDMIAIEEAGIYRGKYFVLNGRISPLDGIGPSELKLDILQQIIADRKIDEVILAISPTVEGETTAHFISQMIAKDIKISRIGFGVPFGGELEYLDQQTLLHAFNARTNI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RS10_CLAMS
Sequence: MAGQKIRIRLKSYDHSVIDSSARKIVDTVTRAGATVVGPVPLPTEKNVICVIRSPHKYKDSREHFEMRTHKRLIDIVDPTPKAVDSLMRLDLPADVNIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RL6_METPB
Sequence: MSRVGKKPVPVPSGVTATVTGQTVKMKGSKGELQFVVPPQVIVEFKDGAVSVQPKDQSKQARSLWGTSRAQVANLVEGVSKGFEKKLEITGVGYRAAMAGKALKLSLGYSHDIEYEIPAGITIVTPKPTEIVVSGIDRQRVGQVAAEIREYRGPEPYKGKGVKYAGEFIFRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: BPIA1_HUMAN
Sequence: MFQTGGLIVFYGLLAQTMAQFGGLPVPLDQTLPLNVNPALPLSPTGLAGSLTNALSNGLLSGGLLGILENLPLLDILKPGGGTSGGLLGGLLGKVTSVIPGLNNIIDIKVTDPQLLELGLVQSPDGHRLYVTIPLGIKLQVNTPLVGASLLRLAVKLDITAEILAVRDKQERIHLVLGDCTHSPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVCPLVNEVLRGLDITLVHDIVNMLIHGLQFVIKV
What is the function of this protein?
Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608).  Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494).  Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P. aeruginosa and K. pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151).  Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776).  Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234).  May attract macrophages and neutrophils (PubMed:23132494).
What are the official names of this protein?
BPI fold-containing family A member 1, Lung-specific protein X, Nasopharyngeal carcinoma-related protein, Palate lung and nasal epithelium clone protein, Secretory protein in upper respiratory tracts, Short PLUNC1, SPLUNC1, Tracheal epithelium-enriched protein, Von Ebner protein Hl.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
Protein: SYP_YERPA
Sequence: MRTSQYLLSTQKETPADAEVISHQLMLRAGMIRKLASGLYTWLPTGVRVLKKVENIVREEMNNAGAIEVSMPVVQPADLWQESGRWEQYGPELLRFVDRGERPFVLGPTHEEVITDLIRGEINSYKQLPLNFFQIQTKFRDEVRPRFGVMRAREFLMKDAYSFHTTQESLQETYDAMYTAYSKIFSRMDLNFRAVLADTGSIGGSASHEFQVLAESGEDDIVFSTGSDYAANIEFAEALAPTEPRAPATEELRIVDTPNAKTIAELVEQFKLPIEKTVKTLLVHAHEESGHKLVALLVRGDHDLNEIKAEKLPQVAKPLTFASEEEIRAAIGAGPGSLGPVNLSLPVIADHSVAVMSDFGAGANIDGKHYFGINWERDLALPLVADLRNVVEGDISPDGKGTLQIKRGIEVGHIFQLGTKYSEVMKATVQGEDGRNQVMTMGCYGIGVSRVVAAAIEQNHDDRGIIWPDAIAPFQVAILPMNMHKSFRVKELAEELYTTLRSHGIDVILDDRKERPGVMFADMELIGVPHNIVIGDRNLDSEEVEYKNRRVGEKQMIKTSEIVEFLLSQIKR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_HAEIG
Sequence: MSRPRKRWRDVDGVFLLDKPQGMSSNDIMQKVKRLFQANKAGHTGALDPLATGMLPICLGEATKFSQFLLDADKRYLVTAKLGERTDTSDAEGQVVETREVHVETPQILTALEQFRGDILQVPTMFSALKHNGKPLYEYARQGITVEREARPITIFELNFIEYHAPFLTLEVHCSKGTYIRTLVDDLGEVLGCGAHVTMLRRTAVADYPVAEMMLINELELLAESFPLSELDRLLLPTDTAVSKLPALHLDVEQSKAIGFGQRVKFANEQQLSGQVRLFSAENLFLGVALIDGNIIRPQRLITQSA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: ASPQ_PSEFA
Sequence: MKSALKTFVPGALALLLLFPVAAQAKEVETKTKLANVVILATGGTIAGAGASAANSATYQAAKVGIEQLIAGVPELSQIANVRGEQVMQIASESINNENLLQLGRRVAELADSKDVDGIVITHGTDTLEETAYFLNLVEKTDKPIIVVGSMRPGTAMSADGMLNLYNAVAVAGSKDARGKGVLVTMNDEIQSGRDVSKMINIKTEAFKSPWGPLGMVVEGKSYWFRLPAKRHTMDSEFDIKTIKSLPDVEIAYGYGNVSDTAVKALAQAGAKAIIHAGTGNGSVSSKVVPALQELRKQGVQIIRSSHVNAGGFVLRNAEQPDDKYDWVVAHDLNPQKARILAMVALTKTQDSKELQRMFWEY
What are the official names of this protein?
Glutaminase-asparaginase, L-ASNase/L-GLNase, L-asparagine/L-glutamine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GLP1_BETPN
Sequence: ILGLNTLGVSLAR
What is the function of this protein?
May play a role in plant defense.  Probably has no oxalate oxidase activity even if the active site is conserved (By similarity).
What are the official names of this protein?
Germin-like protein 1, Cupin.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: QRIC2_MOUSE
Sequence: MENSVSEASLYLQDQLDKLRTIIESMLGSSSTLLSMSITPHKSTACLVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSGLAASRPSKKAKLQGQDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEVLYQGIERLDKEKANREHLEMEIDEKADKSALASKVSRIQFDATTEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDSKLDRLELDPLKQMLEDRWKSLRQQLKERPPLYQADEAAAMRRQLLAHFHCLSCDRPLETTVTGQVISVTPIISSMPGHRSVRPYTVFELEQIRQQSRNLKLGSSFPRVDMSQMERSVGRLHSMHSRMLMDMEKVQVHFGGSVKASSQMIRELLHTQCLSHPCYKRGADTADYSYSTVSRRCGGSHTLTYPYRRNRPQHLSPLEEIQIAMKHDEVDILGLDGHIYKGRMDTRLPGILGKDAPGVTKHNKAKLQQLQQLQQLQQLQQLQQLQQAQHARPHAHRQPSLGNMISPPSRPQSAQMIADSKAVPSGQKKDRPVSSEGRLLQSNVSHSSIPTDIASLQGSQQGLNMHIDVPPGEGLEEPTRGPRSTAAH
What is the function of this protein?
Has an essential role in the formation of sperm flagella and flagellar structure maintainance.  It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility.
What are the official names of this protein?
Glutamine-rich protein 2.
What are the subcellular locations of this protein?
Nucleus membrane. Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=Localization varies during spermatozoa development. The protein is distributed in the nuclear membrane of the spermatogonia, in the nucleus of round spermatids, in the nucleus and cytoplasm of early elongating spermatids, in the cytoplasm of late elongating spermatids, and in the flagella of epididymal spermatozoa.
Protein: VNPA_PSEAU
Sequence: SDPKIGNGCFGFPIDRIGSVSGLGCNRLVQNPPKPISGES
What is the function of this protein?
Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity.  Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity).
What are the official names of this protein?
Natriuretic peptide PaNP-a.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.