PharMolix/UniProtQA huggingface dataset:
Protein: SYFA_SHEB2
Sequence: MQQLTEIVEQALVIIDQASDLKALDDIRVDYLGKKGKITDMMKMMGSLSPEEKPAFGQAVNDAKQAIQQKLTERIDGLKSSELEAKLIAEKIDVTLPGRTQEIGGLHPVTRTIERIETFFGELGFSVKQGPEIEDDFHNFDALNISEHHPARADHDTFYFNPKLMLRTQTSGVQIRTMETEKPPLRIISPGRVYRNDYDQTHTPMFHQVEGLLVDEHVNFAELKGILHDFLRNFFEEDLQVRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRSVGIDPEKYSGFAFGMGVERLTMLRYGVNDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSHB_EQUQB
Sequence: MEMLQGLLLWMLLSVGGVWASRGPLRPLCRPINATLAAEKEACPICITFTTSICAGYCPSMVRVMPAALPPIPQPVCTYRELRFASIRLPGCPPGVDPMVSFPVALSCHCGPCRLKTTDCGGPRDHPLACAPQASSSSKDPPSQPLTSTSTPTPGASNRSSHPLPIKTS
What is the function of this protein?
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
What are the official names of this protein?
Lutropin/choriogonadotropin subunit beta, LSH-B/CG-B, Luteinizing hormone subunit beta, Lutropin/choriogonadotropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RF1_METPP
Sequence: MKPALRLQLDRYVRRLAELDSLLADPAVMRDAGGFRALSREHVEVSGIVERQRRHAQRERDLAAAAEMASDPELAAMAAEEAASAQAELDRLATELQRLLLPRDPDDARSVFLEIRAGTGGDESALFAGDLLRMYTRYAERKGWRVELLSASDSELGGYKEVVARIEGDAVFGHLKYESGGHRVQRVPATETQGRIHTSACTVAVLAEPDEAQEVTLNPADLRIDTYRASGAGGQHVNKTDSAVRITHLPTGLVAECQDDRSQHRNKAKAMAVLAARLRDKDRLERQAREAATRKSLIGSGDRSDRIRTYNFPQGRLTDHRINLTLYQLGAIMDGDLDPVVKALVAAREAELLAELEIG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_ENT38
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGSLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEDIDQKSLQEAVMEEIIKPVLPTEWLNASTKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKLPTEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAAVLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAR8_KARBI
Sequence: ARTDNFVRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-8, FMRFa-8.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRE_THIDA
Sequence: MSDYRAEFVEFAVASQVLCFGEFKTKAGRLSPYFFNAGLFNDGEKLKRLGEFYAKAIVDSGIAFDVMFGPAYKGIPLAASIVIALAGMGRNVPFAFNRKEAKDHGEGGTVVGAPLQGRVLIVDDVISAGTSVRESVDLIRASDATPAGVVIALDRMERGQGDKSAVQEVREQYDIPVVAVVTLDNLVEFLERDANRRTELQAVANYRENYGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: TTCA2_FRATO
Sequence: MTNNTDKQTLKKLERQILRKTTQVINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFPEEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNGSIKAMPTKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKALSNISPSQMLDKELFDFINISKDDIQR
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase 2, Two-thiocytidine biosynthesis protein A 2, tRNA 2-thiocytidine biosynthesis protein TtcA 2.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEQA_HAEIN
Sequence: MKIIEVDEELYQYIASQTRSIGESASDILRRLLSLPVHTSIVNDLIITSAETDQKPKQAINVKEVNIKTTKKQSITAINQIVEKVQTLLNSTEFQEESKAVVRFLAILRVLYRTNPESFAQATESLQGRTRVYFARDEATLLMAGNHTKPKQIPDTPYWVITNTNSGRKMLMLEGAMQSMELPETLIDEVRSYFTVN
What is the function of this protein?
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle.  Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins.  Repression is relieved when the region becomes fully methylated.
What are the official names of this protein?
Negative modulator of initiation of replication.
What is the protein family that this protein belongs to?
Belongs to the SeqA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERDL2_ARATH
Sequence: MESERLESHLLNKQEEEASSFTSGLLLSTSVVVAGSFCYGCAMSYSSPAQSKIMEELGLSVADYSFFTSVMTLGGMITAVFSGKISALVGRRQTMWISDVCCIFGWLAVAFAHDIIMLNTGRLFLGFGVGLISYVVPVYIAEITPKTFRGGFSYSNQLLQCLGISLMFFTGNFFHWRTLALLSAIPSAFQVICLFFIPESPRWLAMYGQDQELEVSLKKLRGENSDILKEAAEIRETVEISRKESQSGIRDLFHIGNAHSLIIGLGLMLLQQFCGSAAISAYAARIFDKAGFPSDIGTTILAVILIPQSIVVMLTVDRWGRRPLLMISSIGMCICSFFIGLSYYLQKNGEFQKLCSVMLIVGLVGYVSSFGIGLGGLPWVIMSEIFPVNVKITAGSLVTMSNWFFNWIIIYSFNFMIQWSASGTYFIFSGVSLVTIVFIWTLVPETKGRTLEEIQTSLVRLS
What is the function of this protein?
Sugar transporter.
What are the official names of this protein?
Sugar transporter ERD6-like 2, Sugar transporter-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ADHX_BOVIN
Sequence: MANQVIKCKAAVAWEAGKPLSIEEVEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGNYPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAALNAAKVEPGSTCAVFGLGGVGLAVIMGCKMAGAARIIGVDINKDKFARAKEFGASECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGISVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHSLPFDQINEAFDLMHAGKSIRTVVKL
What is the function of this protein?
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.  Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate.  Class-III ADH is remarkably ineffective in oxidizing ethanol.  Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
What are the official names of this protein?
Alcohol dehydrogenase class-3, Alcohol dehydrogenase 5, Alcohol dehydrogenase class-III, Glutathione-dependent formaldehyde dehydrogenase, FALDH, FDH, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITB5_HUMAN
Sequence: MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLRSLPLSSKGSGSAGWDVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILDGDSKNIIQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRKCEGLKIGDTASFEVSLEARSCPSRHTEHVFALRPVGFRDSLEVGVTYNCTCGCSVGLEPNSARCNGSGTYVCGLCECSPGYLGTRCECQDGENQSVYQNLCREAEGKPLCSGRGDCSCNQCSCFESEFGKIYGPFCECDNFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRDGQICSERGHCLCGQCQCTEPGAFGEMCEKCPTCPDACSTKRDCVECLLLHSGKPDNQTCHSLCRDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFTYVELPSGKSNLTVLREPECGNTPNAMTILLAVVGSILLVGLALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFTFNKFNKSYNGTVD
What is the function of this protein?
(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
What are the official names of this protein?
Integrin beta-5.
What is the protein family that this protein belongs to?
Belongs to the integrin beta chain family.
Protein: RBK2_ARATH
Sequence: MNSASAHDLRLLEVDKEKQDPKSPRGALEACLTRCSISSASSSSDDPPPNREAIDNADADTDVQCKNHRASSNWGKFFKLWKRRSMKRLSSFPPLSGAAPPIIKQNKSADPNMNGMVLHDIYDFQSSLQNFSISDIEIATDNFSPENIIGRGGYADVYQGILPEGKLIAVKRLTKGTPDEQTAEFLSELGIIAHVDHPNTAKFIGCCIEGGMHLVFRLSPLGSLGSLLHGPSKYKLTWSRRYNVALGTADGLVYLHEGCQRRIIHRDIKADNILLTEDFQPQICDFGLAKWLPKQLTHHNVSKFEGTFGYFAPEYFMHGIVDEKTDVFAFGVLLLELITGHPALDESQQSLVLWAKPLLERKAIKELVDPSLGDEYNREELIRLTSTASLCIDQSSLLRPRMSQVVELLLGHEDVVMTPREAKIKMMQRTYSEELLDSVEYNSTKYLGDLDRIREVALAS
What are the official names of this protein?
Receptor-like cytosolic serine/threonine-protein kinase RBK2, Protein ROP BINDING PROTEIN KINASES 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AK_RICFE
Sequence: MALIIQKFGGTSVANIDRIKKIAPIIKAEIAKNNQVIVVVSAMAGVTNQLVTLCNEVSSLNNISQFAEYDVALSSGEIVTASLLALALQEEDIKAQSFLAWQLPILTDNNHSKALVESITTDLLEKYLQLNTVPIIAGFQGTNKSNRLTTLGRGGSDTTAALIAAAMKAKRCDIYTDVEGIFTADPRIIPNAKKIKEIDFLEMLELASSGAKVLHPRAVELVMRYKIDMRVLSTFSPNTEGTLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANMITQNNNHIEFMQEIKNNEEYSFITNLTDENNLQALLTNLKNDKQIQDFTFDAEIATISLIGYGIKNDCKVLEMILSKLTKDNINVNMIQLSEVKITLLINDQDAEKTIFNLYNLFKIS
What are the official names of this protein?
Aspartokinase, Aspartate kinase.
What is the protein family that this protein belongs to?
Belongs to the aspartokinase family.
Protein: RFA1_XENTR
Sequence: MALPVLSEGAISAILGGDSSCKPTLQVINIRSINTGNGPPRYRLLMSDGLNTLSSFMLATQLNFLVDNNLLATNCICQVSRFIVNNLKDGRRVIIVMEMEVLKSADLVKGKIGNPHPYNDGQGPPQPAAPAPASAPPPSKPQNISAPPPPSMNRGASKLFGGGSVVNTPGGSQSKVVPIASLNPYQSKWTVRARVTNKGQIRTWSNSRGEGKLFSIEMVDESGEIRATAFNEQADKFFSLIEVNKVYYFSKGTLKIANKQYTSVKNDYEMTFNSETSVIPCDDSADVPMVQFEFVPIGELESKNKDTVLDIIGICKNAEEVTKVTIRSNNREVSKRNINLMDSSGKVVSTTLWGEDADKFDGSRQPVVAIKGARLSDFGGRSLSVLSSSTVMINPDIPEAFKLRAWFDSEGQVVEGTSISESRGGTGGGNTNWKSLLEVKTENLGHGEKADYFTSVATIVYLRKENCLYQACPSQDCNKKVIDQQNGLFRCEKCDKEFPNYKYRLILSANIADFGENQWITCFQESAESILGQNATYLGELKEKNEQAYDEVFQNANFRSYTFRIRVKLETYNDESRIKATAMDVKPVDHKEYSRRLIMNIRKMAAQGV
What is the function of this protein?
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress.  It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism.  Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
What are the official names of this protein?
Replication protein A 70 kDa DNA-binding subunit, RP-A p70, Replication factor A protein 1, RF-A protein 1.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 1 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body.
Protein: COE1A_DANRE
Sequence: MFGIQDSIQRSGSSMKEEPIGAGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTSFVGFVEKEKESTGEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYNVPRGHNQLPGLTNSSVHSGMMGVNSFHSQLAVNVSDSTQAANQGFSRNTSSVSPHGYVPSTTPQQSSYSTVSTSMNGYGNAGMTTLGGSPNFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQASPPPTCTSANGNGLQVIPGMIVPPM
What is the function of this protein?
Transcriptional activator.
What are the official names of this protein?
Transcription factor COE1-A, Early B cell factor 1-A.
What is the protein family that this protein belongs to?
Belongs to the COE family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RRT5_YEAS6
Sequence: MTEQVNNDTTSDTTTTITTVYISNLPFTASERDLHAFLNNYGASSVLIPTQTVRRFSKRHNSNPRKPLGIAFAQFANNTLALKAIQDLNGTVFQNQKLFLKLHVPYEADSTPDTDVKKPKEKNKVKKTPETAADTVYCHDLPDDITDSEIRELFQLYSPQEIWIYRSKVYRRKCIPFAPHQITAALVTLQSETPIGDICDSVAKTATLRGKSIIVKPAYVSKIQEIKQLVKDNLTNARDPPPAALAEPAPAPAPVEPAEQVQEGQDNAETNDVPPPPASSSDRPTVAAT
What is the function of this protein?
May be involved in the modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription protein 5.
What is the protein family that this protein belongs to?
Belongs to the RRT5 family.
Protein: RL32_SULTO
Sequence: MNKQINIRKIQEKIKKIREKKIKFLRYDWDKFYRIGRQETWRKPKGIDNPVRLELKGYQPKVKIGFRSPREIRGLHPSGLIPFYVNNKKDLEKASQMKDKVIVVFSSTIGLKKKLELVEEAKKMGLKIANG
What are the official names of this protein?
50S ribosomal protein L32e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
Protein: RNPA_LACH4
Sequence: MRKSYRVKSEKDFQQVFESGNSVANRAFVIYKVEKPENKHFRVGISVGKKVGHTAVARNRLKRYIRAVIDEEKLEIDPQVDFLIITRPYARNFDMVKVRKNLLHALALAHIIEEMPDEVEEN
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: DDR1_PANTR
Sequence: MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV
What is the function of this protein?
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation.  Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases.  Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing.  Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing.  Also plays a role in tumor cell invasion.  Phosphorylates PTPN11.  Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation.  Required for normal ear morphology and normal hearing (By similarity).
What are the official names of this protein?
Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Discoidin receptor tyrosine kinase, Tyrosine kinase DDR.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RS18_JANSC
Sequence: MAAKPFFRRRKTDPFEGENAPKIDYKDTRLLQRYISERGKIVPSRITAVGAKNQRALAKAIKRARFLALLPYAVK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: FB41_ARATH
Sequence: MEKSQSSCDTRKRSVVVDVDNTKDRISDLPNRILGKIIVKLPLDEAVRIMALSKRWKSIWDDN
What are the official names of this protein?
Putative F-box protein At1g47702.
Protein: PIF1_YEAS7
Sequence: MPKWIRSTLNHIIPRRPFICSFNSFLLLKNVSHAKLSFSMSSRGFRSNNFIQAQLKHPSILSKEDLDLLSDSDDWEEPDCIQLETEKQEKKIITDIHKEDPVDKKPMRDKNVMNFINKDSPLSWNDMFKPSIIQPPQLISENSFDQSSQKKSRSTGFKNPLRPALKKESSFDELQNSSISQERSLEMINENEKKKMQFGEKIAVLTQRPSFTELQNDQDDSNLNPHNGVKVKIPICLSKEQESIIKLAENGHNIFYTGSAGTGKSILLREMIKVLKGIYGRENVAVTASTGLAACNIGGITIHSFAGIGLGKGDADKLYKKVRRSRKHLRRWENIGALVVDEISMLDAELLDKLDFIARKIRKNHQPFGGIQLIFCGDFFQLPPVSKDPNRPTKFAFESKAWKEGVKMTIMLQKVFRQRGDVKFIDMLNRMRLGNIDDETEREFKKLSRPLPDDEIIPAELYSTRMEVERANNSRLSKLPGQVHIFNAIDGGALEDEELKERLLQNFLAPKELHLKVGAQVMMVKNLDATLVNGSLGKVIEFMDPETYFCYEALTNDPSMPPEKLETWAENPSKLKAAMEREQSDGEESAVASRKSSVKEGFAKSDIGEPVSPLDSSVFDFMKRVKTDDEVVLENIKRKEQLMQTIHQNSAGKRRLPLVRFKASDMSTRMVLVEPEDWAIEDENEKPLVSRVQLPLMLAWSLSIHKSQGQTLPKVKVDLRRVFEKGQAYVALSRAVSREGLQVLNFDRTRIKAHQKVIDFYLTLSSAESAYKQLEADEQVKKRKLDYAPGPKYKAKSKSKSNSPAPISATTQSNSGIAAMLQRHSRKRFQLKKESNSNQVHSLVSDEPRGQDTEDHILE
What is the function of this protein?
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.  Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids.  Appears to move along DNA in single nucleotide or base pair steps, powered by hydrolysis of 1 molecule of ATP.  Processes at an unwinding rate of about 75 bp/s.  Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs.  Involved in the maintenance of telomeric DNA.  Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase.  Reduces the processivity of telomerase by displacing active telomerase from DNA ends.  Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction.  Involved in the maintenance of ribosomal (rDNA).  Required for efficient fork arrest at the replication fork barrier within rDNA.  Involved in the maintenance of mitochondrial (mtDNA).  Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks.  May inhibit replication progression to allow time for repair.  May have a general role in chromosomal replication by affecting Okazaki fragment maturation.  May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase PIF1, DNA repair and recombination helicase PIF1, Petite integration frequency protein 1, Telomere stability protein 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. PIF1 subfamily.
What are the subcellular locations of this protein?
[Isoform Nuclear]: Nucleus, nucleolus. Note=Mainly concentrated in the nucleolus, and occasionally redistributes to single nuclear foci outside the nucleolus, probably sites of DNA repair. SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Bound to the mitochondrial inner membrane either directly or indirectly via a protein complex.
Protein: MTNB_NEOFI
Sequence: MAQEVENNNNDHLVQSSDPEHPANLIPELCRKFYNWGWVTGTGGGTSIRRGDHIFIAPSGVQKELIQPHNIFVLEFPTPKYPPSDRKYIRKPLELKPSACTPLFLTAFERGAGCCIHTHSQWAVLVTLLVEREKGPDACFEISNIEQIKGIPRGKGKGMLGFFDTLKIPIIENTAFEEDLTGSLEKAMDQYPDTYAVLVRRHGIYVWGDDVAKAKTQCESLDYLFQLAVEMHKLGLPWVK
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFBU_ECO24
Sequence: MEMTNAQRLILSNQYKMMTMLDPANAERYRRLQTIIERGYGLQMRELDREFGELKEETCRTIIDIMEMYHALHVSWSNLQDQQSIDERRVTFLGFDAATEARYLGYVRFMVNVEGRYTHFYAGTHGFNAQTPMWEKYQRMLNVWHACPRQYHLSANEINQIINA
What are the official names of this protein?
UPF0304 protein YfbU.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: RUVC_SOLUE
Sequence: MRVLGVDCGSERTGWGVIDSDGGCHRMVAAGVIRTSPKCPFDRRLLEIGTALRGLIREHTPEFAAVEEVFHAVNAKTALKLAHVRGVALLTIAEAGVVFAEYSPLEVKMSVVGYGRAEKSQVQMMVQSLLRLPEVIASEDASDALAIAICHATHQATHEATSRRLG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: ATRF2_STAAW
Sequence: MTEKEKMLAEKWYDANFDQYLINERARAKDICFELNHTRPSATNKRKELIDQLFQTTTDNVSISIPFDTDYGWNVKLGKNVYVNTNCYFMDGGQITIGDNVFIGPNCGFYTATHPLNFHHRNEGFEKAGPIHIGSNTWFGGHVAVLPGVTIGEGSVIGAGSVVTKDIPPHSLAVGNPCKVVRKIDNDLPSETLNDETIK
What are the official names of this protein?
Putative acetyltransferase MW2476.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: LCK8_RHYMA
Sequence: GADFYSWG
What is the function of this protein?
This cephalomyotropic peptide stimulates contractile activity of cockroach protodeum (hindgut).
What are the official names of this protein?
Leucokinin-8, Leucokinin VIII, L-VIII.
What are the subcellular locations of this protein?
Secreted.