PharMolix/UniProtQA huggingface dataset:
Protein: PLCZ1_MACFA
Sequence: MEMKWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKRIFKDNDRLKQGRITIEEFRAIYRILTHREEIVEIFNAYSENRKILLENNLVQFLTQEQYTTEMSKTIAFEIIQKYEPIEEVRKARQMSLEGFTRYMDSRECQLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLVGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSPAQQEIMADNLQTTFGESLLSDMLADFPDTLPSPEALKFKVLVKNKKIGTLKETHERKGSDKRGKVEEWEEEVADLEEEEEEEEKFKESEIFESVLGENQDKETGVKKLSGVTLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRAHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESESYFNPSDIKDSMPITLTIRLISGIQLPLTHSSSNKGDTLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVPELALIRFVVESQGLIAGNEFLGQYTLPLLCMNKGYRRVPLFSRMGESLEPASLFVYVWYVR
What is the function of this protein?
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.  In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner.  Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage.  Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion.  May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1, Phosphoinositide phospholipase C-zeta-1, Phospholipase C-zeta-1, PLC-zeta-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity).
Protein: EFP_BARHE
Sequence: MKINGNEIRPGNVIEHQGSLWVAVKCNAVKPGKGGAFNQVEMKNLIDGTKLNERFRAAETVERVRLEQKDFTFLYQQGDALIFMDSQSYEQLELQKDFVGERAAFLQDGMTVTVELYQEKPIGISLPDQVSVTIVEADPALKGQTVTASYKPAILENGIRILVPPFINAGERIIVDTNELIYVRRANEKDK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERG24_NEUCR
Sequence: MAGKQNQAAPKKAVAPRQQHYEFGGPIGAFGITFGLPILVHVFNLFCNDISGCPAPSLLHPKSLDLAQLKREIGWPDNGVFGLFSWSATLWTLGYYALSLVQYRFLPGHHVEGTELSTGGRLKYKLNAFNSAMCTLAILAAGTIAQGAEFPVWTFISDNFAQIISANILFAFALAIFVYVRSFDVKPGNKDMRQLAAGGVTGSLIYDFYIGRELNPRITLPLIGQVDIKEFMEMRPGLLGWIILNCAFIAKQYRLYGYVTDSILFITAIQAFYVFDGIYMEPAVLTTMDITTDGFGFMLSFGDVVWVPFMYSTQTRYLSVHPQQLGAFGLIAVGAVLAAGYSIFRLSNSQKNNFRTNPEDPSVKHLTYLQTKTGSRLITSGWWGIARHINYLGDWLQSWPYSLPTGIAGYQILSAGSNAPGAITMLDGREVVQGEARGWGIVFTYFYILYFAILLIHRDLRDDEKCSKKYGDDWEKYKKLVKWRIVPGIY
What is the function of this protein?
Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol.
What are the official names of this protein?
Delta(14)-sterol reductase, C-14 sterol reductase, Sterol C14-reductase.
What is the protein family that this protein belongs to?
Belongs to the ERG4/ERG24 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RCSB_ECO57
Sequence: MNNMNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDKYGDGITLIKYIKRHFPSLSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISAGGYGDKRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLSSVTLSPADKD
What is the function of this protein?
Component of the Rcs signaling system, which controls transcription of numerous genes.  RcsB is the response regulator that binds to regulatory DNA regions.  Can function both in an RcsA-dependent or RcsA-independent manner.
What are the official names of this protein?
Transcriptional regulatory protein RcsB.
What is the protein family that this protein belongs to?
Belongs to the RcsB family.
Protein: CLPB2_NOSS1
Sequence: MQPTNPNQFTEKAWEAIAHTPEIAKQHQQQQIESEHLMKALLEQDGLASGILTKAGVNLQKISDRTEQYIQRQPKVSGNSTSVYLGRSLDTLLDRAEAHRKDFQDEYISIEHLLLAYPKDDRFGKGLFQEFALDESKLKNIIKQVRGSQTVTDQNPEGKYQSLEKYGRDLTEAARKGQLDPVIGRDDEIRRTIQILSRRTKNNPVLIGEPGVGKTAIAEGLAQRIVAGDVPQSLKDRKLISLDMGAMIAGAKFRGEFEERLKAVLKEVTESGGNIVLFIDEIHTVVGAGATQGAMDAGNLLKPMLARGELRCIGATTLDEYRKYIEKDAALERRFQQVYVDQPSVEDTISILRGLKERYEVHHGVKISDSSLVAAATLSSRYISDRFLPDKAIDLVDEAAARLKMEITSKPEELDEIDRKILQLEMEKLSLQKESDAASRERLERLEKELADLKEEQRTLNTQWQSEKDVINKLQSVKEEIDKVNLEIQQAERNYDLNRAAELKYGNLTDLHRRLEATERELSQTQGTGKSLLREEVTEADIAEIISKWTGIPISKLVESEKEKLLHLEDELHHRVIGQDEAVTAVADAIQRSRAGLADPNRPTASFVFLGPTGVGKTELAKALASYMFDTEDALVRIDMSEYMEKHAVSRLIGAPPGYVGYEEGGQLTETIRRRPYAVILFDEIEKAHPDVFNIFLQILDDGRVTDAQGHTVDFKNTIIIMTSNIGSQYILDIAGDNSRYDEMRHRVMEAMRNSFRPEFLNRIDEVIIFHSLDKKELRQIVQLQVERLKARLDDRKISLRLSDVALDFLAEVGYDPVFGARPLKRAIQRELETQIAKAILRGEFNDGDTIFVDVQNERLSFSRLPVEVFSS
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB 2.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_SHEWM
Sequence: MAIERTFSIIKPDAVAKNNIGAIYNRFETAGLKIIASKMVHLSKEQAEGFYAEHSERPFFGALVAFMTSGPIMVQTLEGENAVLAHRDILGATNPAEAAPGTIRADFAESIDENAAHGSDSVASAEREVAYFFSAEELCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_MARN8
Sequence: MAQNIHDHRILILDFGSQYTQLIARRVREIGVYCEIKAFDITDDELNEFNPKGIILAGGPESVTQLGGPRAPEGLFDRGIPVLGICYGMQTMAEQLGGRVASSEKREFGYAQVKVRAKGPLLADITDHLTPAGDSLLDVWMSHGDKVVAMPEGFELLASTESAPIAAMQDLSRNLYGVQFHPEVTHTLQGKRILEHFVLTISGCEALWTPAKIVDDAVRQIREQVGSDKVLLGLSGGVDSSVTAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMDMFASNMGVKVIRVDAEDLFLSKLKGVNDPEQKRKIIGNTFIDVFDDEAANIKDVNWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPETMKMKLVEPLRELFKDEVRKIGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEYADILRRADAIFLEELHRADLYHKTSQAFAVFLPVKSVGVVGDARRYEYVIAIRAVETVDFMTARWARLPYELLETVSNRIINEISGVSRVTYDISSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: G2E3_CHICK
Sequence: MSENNFDIQSPPCVLCGWTDNCPEKYGEKRTYVEYNLTLHNYCLLMSSGIWQRGEENEGVDGFLIEDIRKEVNRAARLMCNICRKKGASIGCVAPKCKRSYHFPCGLQKECVFQFMEDFRSYCWEHKPVQIFSDKESREPSQCTICLDLVEHLPLYSVLRSPCCKNTWFHRECLQYQALSAGIFFFRCAVCNNKDKFQKEMLRMGIHIPEKDASWELEDNAYQDLLQCYQHCDIRRCLCKNGRDYNKPDSKWEIKRCQSCGSRGTHLACSSIKSWEQNWECVECRSIFAKGKYSKRKKHSLAPSEKMDGTTCLLEEPSPKLPRQSPGSQRNCLLQSPKIICQNNLSPCSLLELPTSNRVAMSLSPLMSNRNCSLRKKHLRMQRKEASNILKELKQQINTKTTRLNINTENIWNSALKGFRQRNFRPTNTIEVKFTNCKNRVKTDSFTGSKHLFFHLLMLHIQNSSLFEGSSAKNLSVDPQALKENLYFEAGKMIAVSLVHGGPSPGFFSKILFDCLVYGPENVKPNLDDVADAGVAQTIKKIKYSESLSSLQSTVRDCYDFLAAAGCLRPITSLRDKDMLVNDLLIHHVIKRIISPLESFRQGLKTLGLLEKMEMHQDAFSSLFCHKPENLSAEALCDLFTIHSSPDVNKVGAADFWMGYLQDVESGESVVTLQDILFFVTGCSSIPPIGFDPEPTIKFLPVHYPIGNRLLNCLELPITRTYENFKNKMEFTIRSTLRGERE
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Essential in early embryonic development to prevent apoptotic death.
What are the official names of this protein?
G2/M phase-specific E3 ubiquitin-protein ligase, G2/M phase-specific HECT-type E3 ubiquitin transferase.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage.
Protein: DUS12_RAT
Sequence: MLEVQSSNHGCERQAPTTSPASSAGHAVEVRPGLYLGGAAAVAGPDYLREAGITAVLTVDSEPAFPAGAGFEGLQSLFVPALDKPETDLLSHLDRCVAFIGQARSEGRAVLVHCHAGVSRSVAVVTAFIMKTEQLTFEKAYENLQTIKPEAKMNEGFEWQLKLYEAMGHEVHTSSAVYKQYRLQKVTEKYPELRNLPRELFAVDPTTVSQGLKDDILYKCRKCRRSLFRRSSILDHSEGSGPVAFAHKRTGLSSVLTTGNQAQCTSYFIEPVQWMESALLGVMDGQLLCPKCSAKLGSFNWYGEQCSCGRWITPAFQIHKNRVDEVKTLPALGSQTKKP
What is the function of this protein?
Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues.  Can dephosphorylate glucokinase (in vitro).  Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates.
What are the official names of this protein?
Dual specificity protein phosphatase 12, Glucokinase-associated dual specificity phosphatase, GKAP.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytosol. Note=Primarily nuclear. Detected in a mesh-like pattern in the cytosol.
Protein: RL7_BRUA1
Sequence: MADLAKIVEDLSALTVLEAAELSKLLEEKWGVSAAAPVAVAAAGGAAPAAAAEEKTEFDVVLADGGANKINVIKEVRALTGLGLKEAKDLVEGAPKAVKEGASKDEAEKIKAQLEAAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: COQ4_CAEEL
Sequence: MSAQKLYASHVPLAPLSRMLLGIGSAVTAISDPKRGDMVAAMGETTAIGPVLENIRKRMESDVVGKRLLLEKPRISNGTIDRKWLRQLPDGTLGKLYSNFLDRLNTSPDARPTVKYIDNLEHLYVMQRYRETHDFTHIALEQKTNMLGEVTVKYFEGIQYGLPMCVTGGIFGGARLLTKNRQELVDRNLPWVVEQATNARFFMAFDWENHFEKQLSEVQKELNITPLSVNM
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein coq-4, mitochondrial, Coenzyme Q biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: GLP1_BRANA
Sequence: MLRIIFLLSLLFALSNDSVQDFCVANLKRAETPAGYPCIRPIHVKASDFVFSLGTPGNTTNIISAAVTPGFVAQFPALNGLGISTARLDLAPKGVIPMHTHPGASEVLFVLDGSITAGFISSANSVYVQTLKPGQVMVFPQGLLHFQINAGKTPAAALVTFSSASPGLQILDFALFANTLSTELVSATTFLPPATVKTLKGVLGGTG
What is the function of this protein?
May play a role in plant defense.  Probably has no oxalate oxidase activity even if the active site is conserved.
What are the official names of this protein?
Germin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: RS6_THEM4
Sequence: MRIYETMFIIKPDIAEEEREKIAQGVVDYLKEKLGAHVDNVDRWGIRKTAYPLKKYNEADYTIVYFRGEGLDITVLESYFRVRPEFLRWQTFRRIDLEKKEKKQSRKEEGSENSEKVEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RS16_GLOC7
Sequence: MIKLRLKRYGKKREVSYRIVAMRSTSRRDGRPLEELGFYNPRTDETRLNVPAIVKRLQDGAQPTETVRNILQKAKVFEQVNA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: ALG8_AZOVI
Sequence: MDRLKHALGEATGWLLFLSFLMLVAVALPPQVFDPESKHFIMLIGLIGVWRYSMGIIHFLRGMLFLYVVYPYYRRKVEKLGKDADPSHVFLMVTSFRIDALTTGKVYGSVIKEAINCGYPTTVVCSIVEMSDELLIKSLWEKLDPPDRVKLDFVRIAGTGKRDGLANGFRAISRHMPDEDAVVAVIDGDTVLNEGVVRKTVPLFQDLPQHGWPDHQRILRSAGRLRHERVAQVRFAQRHINMCSMALSHRVLTLTGRMSVFRAVVTDPEFIVDVENDNLDHWRLGRFKFLTGDDKSSWFSLMRLGYDTFYVPDASIHTVEHPPEKRFVKASRKLMFRWYGNNLRQNSRALKLGVQRLGWFTSVVLFDQRVSMWTSLLGLTVAIIGSIKYSIAIFIAYLLWVCSTRLVLTLLLSLSGHPIGPAYPLILYYNQIVGAVVKIHVFFRLDQQSWTRQDTKLNRELASFQSWFNNWSSKAMTFSATSIFIAVLMLSV
What is the function of this protein?
Possibly a processive enzyme that polymerizes GDP-mannuronic acid.
What are the official names of this protein?
Glycosyltransferase alg8.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISCS_SHIF8
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLRNRLWNGIKDIEEVYLNGDLEHGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.  Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_SPHAL
Sequence: MAKTDDFKAKTDDQLAEQLGELKREAFNLRFQAATGQLEKASRVKEVRRSIARIKTVQTERARSAAK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: MURG_WOLPM
Sequence: MDIILATGGTGGHIFPAIALAKALKTQGYNCILFTDKKTNKNTDIESYTLPLRRPSSNKFKFFLFLIYSSMLALYQVRKLKPKSVIGFGSYASFPTLLAARVLSIPIILHEQNTVLGRVNRFFFKSAKLIATSFPETKYAEGNKCIFTGNFVDIKAQSHSSTEKILNILVIAGSQGANFFDDVVSSVICDLPIKMKKKIRVTQQCTKKNVNKVKSLYKSEKIDCELSEFFDDMENRLANAHLVISRAGATSIAEITLARRSAIYIPYPYSKDNHQFYNAKYIEDSRAAIIVKQNSEAKKNLTEVLFDLLNNSQKLRDMTNSTEKTGIKNGTTEFVKVIVHRFS
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MNME_YERPP
Sequence: MSTTDTIVAQATPPGRGGVGILRVSGRAASEVAHAVLGKLPKPRYADYLPFKDVDGSTLDQGIALYFPGPNSFTGEDVLELQGHGGPVILDLLLKRILALPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSAVNSLQGAFSARIHQLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEGQLNGVMADLEQVRTEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREANDEVERIGIERAWNEIEQADRVLFMVDGTTTDATEPAAIWPEFMARLPATLPITVVRNKADITGETLGLTKVNGHSLIRLSARTGEGIDLLRDHLKQSMGFTSNTEGGFLARRRHLQALETAARHLIQGHEQLVSAYAGELLAEELRLAQQSLSEITGEFSSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMDH_STAAN
Sequence: MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSF
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: XOATC_ORYSJ
Sequence: MWSALFSHLREVHKRSGVKEEKLIMKSPAAAGEAAGCHKPQATATNKMTVLQSPLGLRTILTSLVAFFIVVSSVSLLFDRSQDAQAQLAVAQHQHQEVQLKQKPASAAVGEQKSVFVDQSSLRSQEAQVQWTSELQDVATDSGDGGVDGEEECNWSLGRWVYDNSSRPLYSGLKCSFIFDEVACDKYGRNDTKYQHWRWQPHGCNLPRFNATKFLEKLRNKRLVFVGDSVNRNQWVSMVCMVEHFIPDGRKMRVYNGSLISFKAFEYNATIDFYWSPLLLESNSDNPIIHRVEYRIIRADRIEKHANVWKDADFIVFNSYLWWRKQRDGMTMKVMYGSFEDGDAKLDEVEMVDGYEIALKKLTEYLGANINKNKTRIFFAGSSPAHSWASNWGGDDNNKCLNETEPIQIEDYRSATTDYGMMDKAKEIFGTLEPKGIHVQILNITQLSEYRKDAHPTIFRRQYVPLTKEQIANPSIYADCTHWCLPGVPDVWNEFLYAYLMHK
What is the function of this protein?
Xylan acetyltransferase required for 2-O- and 3-O-monoacetylation of xylosyl residues in xylan (PubMed:29569182, PubMed:27864442).  Catalyzes the 2-O-acetylation of xylan, followed by nonenzymatic acetyl migration to the O-3 position, resulting in products that are monoacetylated at both O-2 and O-3 positions (By similarity).
What are the official names of this protein?
Xylan O-acetyltransferase 12, Protein trichome birefringence-like 2, OsTBL2.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: SIAH2_MOUSE
Sequence: MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGAGGGADPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:24809345, PubMed:26070566).  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:26070566).  Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:26070566).  Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia.  Promotes monoubiquitination of SNCA (By similarity).  Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:26070566).  It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:26070566).  Has some overlapping function with SIAH1.  Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not.  Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (By similarity).  Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558).  Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (PubMed:24809345).  Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase SIAH2, RING-type E3 ubiquitin transferase SIAH2, Seven in absentia homolog 2, Siah-2, mSiah2.
What is the protein family that this protein belongs to?
Belongs to the SINA (Seven in absentia) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Protein: YACG_AERS4
Sequence: MVTKVKCPTCKTELEWGPQSPFRPFCSKRCQLIDLGEWADEEKRIPGPINPDLLPYPDEGEQWQ
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: RS12_MYCPN
Sequence: MATIAQLIRKPRKKKKVKSKSPALHYNLNLLNKKVTNVYSPLKRGVCTRVGTMTPKKPNSALRKYAKVRLTNGFEVLTYIPGEGHNLQEHSVTLLRGGRVKDLPGVRYHIVRGTLDTVGVEKRRQQRSAYGAKKPKAKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.