PharMolix/UniProtQA huggingface dataset:
Protein: TOP1M_RAT
Sequence: MLLLWLRALCRRFQHVPRRVPSRQVSRGSKASRAGWGETSKSSVKWKQLEHKGPCFAPAYEPLPDGVRFFYDGKPVRLSLAAEEVATFYGKMLHLECTTKEVFRRNFFSDWQKEMTAEERKLITHLDKCDFSEIHRHFMERAEARRTLPREQKQKLKEEAEKLQQEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVMWLAAWVENIQNSFKYIILNPSSKPKGEMDWQKYEVARRLKGVVDKIRAQYQADWKSPEMKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCCSLRVEHVRLHTPADGQEHVVELDFLGKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDLFDALTTSSLNKHLQDLMEGLTAKVFRTYNASITLQEQLRVLTRAEDSLTCKVLAYNRANRAVAVLCNHQRAIPKTFEESMQTLQKKIETKKAQVAEAQVELQKAETDLRMRGDSKSKSFLQKQQRLLKLEEQLARLCTKATDKEENKQVALGTAKLNYLDPRISIAWCKRFGVPVEKIYNKTQRERFAWAFNQAGEDFEF
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
What are the official names of this protein?
DNA topoisomerase I, mitochondrial, TOP1mt.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: VSPE2_CROAT
Sequence: HVGGDECNINEHRSLVAIFVFTEFF
What is the function of this protein?
Cleaves a kininogen analog to release bradykinin.
What are the official names of this protein?
Kallikrein-like EII.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RR8_PLETE
Sequence: MVNDTISDMLTRIRNANMAKNDLVLIPFTHINLEICQILLKEGFIQSFKTLTLDVSKYSKLNAQKNLNIVVKLKYLGRQKNSCITNLLRISKPGNRIYAKHKIPDMLGGLGIIIVSTSAGIMTDREAREQKIGGELLCSVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CHS8_IPOBA
Sequence: MVTVEEVRKAQRAEGPATILAIGTVTPANCVNQSTYPDYYFRITNSEHKTELKEKFQRMCDKSMITKRYMHLTEEILKENPSFCEYMAPSLDARQDIAVVEVPKLGKEAAQSAIKEWGQPKSKITHVVFCTTSGIDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLIVCSEITVVTFRGPSETHLDSLVGQALFGDGAAAVIVGADPTPAEKPLFQLVSAAQTLAPNSCGAIDGHLREVGLTFHLLKDVPSVVSNNIEKCLFEAFNPLGISDWNSVFWIAHPGGPAILDQVEDKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASSNAGLGTTGEGLEWGVLFGFGPGLTIETVVLHSVPT
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase DIV, Naringenin-chalcone synthase DIV.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: ZIC3_HUMAN
Sequence: MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAGMGLNPFGDSTHAAAAAAAAAAFKLSPAAAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHHTSQVPSYGGAASAAFNSTREFLFRQRSSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAAGAQFPNYSPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIDEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESSTPPAIASANSKDTTKTPSAVQTSTSHNPGLPPNFNEWYV
What is the function of this protein?
Acts as transcriptional activator.  Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification.  Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
What are the official names of this protein?
Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.
Protein: ACEK_METPP
Sequence: MAGSFVTTLNDPRAFDIAQALLDGFNRHYKLFRQTSAEAKQRFEAADWHGQQRAQRERIEFYDLRVDEAAERLENEFRASSLSEETWQQVKLYYIGLLINHHQPELAETFFNSVTTKILHRSYFRNDFIFVRPAVSTEYIENEEPDSLPTYRAYYPSRPGSAEGLRETLLRIVDNYQLQREFEDLGRDIDYVLQAFRNQFGDVKLSANFQIQVLASLFFRNKGAYIVGKVINGFRETGFALPVLHNSRELLTIDTALFGEDELLLLFSFARAYFLVDMEIPSAYVQFLRSLMPRKPRWELYNALGLQKQGKNQFYRDFLYHLRHSSDSFRIAPGIKGMVMLVFDLPSFPFVFKVIKDFYPPQKDTTRELIQSKYQLVKTHDRVGRMADSLEYSNVAFPRQRFEPELIEEIRHFCPSLLEEEGDSLVLKHLYIERRMIPLNIYLQEATPEQMKHAVIEYGNAIKDLVAANIFPGDMLWKNFGVTRHGKVVFYDYDEIEYLTDCNFRKVPEPRTEEEEMSGDIWYSVGPKDVFPETFGPFLLGNPTVREVFMQHHAELLDPAFWQGRKDRIAGGYVHDVFPYDPHKRFRRPLGLGFGSLDAEAVSLHPASATTQLGHNPI
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GWL_AILME
Sequence: MEPTAGSEKESEGDTVTGECVNRIPVPRPPSIEEFTIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFFTPVAEKNKDSANILSTHVSETSQLSQGLVCPMSVDHRDTTPYSSKLLNSCLETVAPNPGMPVKCLTSHLLQSRRRLATSSASSQSHTFVSSVESECHSSPRWEKDCQESDHALGYTVMSWNIIEKPSCTDSRDAIETKGFNKKDLELALSPIHNSSTIPETGRSCVNLAKKGFPGEVSWEARELDINNIHVATDTAQSGFHQSDQWAVDSGDATEEHLGKRGFKRNFELVDSSPCQNIIQHKKNCIEHKPRNAMSDGYINQRTGLTTEVQDLKLSVCGGQQSDCANKENMVNSFIDKPQTPEKSPVPMIAKNLLCELDEDCDKNNKRDLLSSSLLCSDDERASKSICMDSDSSFPGISVMESSLERQSLDPDKSIKESSFEESNIEDLLTVSPRWQENILPKGDENPAVQDSSQKMLAPSSKVLKTLTLSKRNAVAFRSFNSHINASNNSEPSKMSLTSLDGMDISCVYSGSYPMAITPNQKGTSYIPYQQTPNQVKSGTPYRTPKSVRRGAAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNSQNAVEILLTIDNAKRAGMKELKRHHLFSDVDWENLQHQTMPFIPQPDDETDTSYFEARNNAQHLTISGFSL
What is the function of this protein?
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance.  Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively.  ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A.  Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high.  Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase greatwall, GW, GWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes.
Protein: DF289_ARATH
Sequence: MATLKTTIFIIFILYISCTMFVNIFRVQADASCLTTKECVVRCSDEDAQCIHGECHCPHLKVDIEPTKAIRCKTDLDCPDPHQCPKYDYYACLNNGECTCISV
What are the official names of this protein?
Defensin-like protein 289.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: EFP_CHLP8
Sequence: MVSISNVSKGAIIRWKGEPHSIESLVHRTPGNLRAFYQASMKNLKTGRNVEYRFSATEQVDVIVTERKKYQYLYRDGEDYVMMDTETFDQINVPEVAIGSASRFIKDAVMVDIVFADDGSILEVELPTFVELEVTETNPASKDDRATSGTKPAIVETGAEVNVPMFIQTGSIIRIDTRSGEYMDRVKK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_STAES
Sequence: MFMGEFDHQLDTKGRMIIPSKFRYDLNERFIITRGLDKCLFGYTLEEWQQIEEKMKTLPMTKKDARKFMRMFFSGAVEVELDKQGRINIPQNLRKYANLSKECTVIGVSNRIEIWDRETWNDFYDESEESFEDIAEDLIDFDF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DAPE_RICM5
Sequence: MYINYLKDLIGFKSVTPKSDGAIEYIDDLLKQHGFKTEIKIFGDSKSEQVTNLYAVFGSNEPNICFVGHVDVVLAGNHELWHNASPFKASQQDDKIYGRGAVDMKGAIACFLAASLDFIKNNTDFKGSISFLLTSDEEGKAKHGTKEMLQYIYDQGYKINFAIVGEPTCEKEIGDAIKIGRRGSVNFKLNIEGLSGHVAYPHKANNPLPCLIIILNELTNIKLDEGIEFFQRSNLEVTNIEVSNNTSNVIPASTEASFNIRFNNLHSAETLAKQVEEIIKQHCKEYKVDYKLEYSSSAESFIQNPSDKIKEFAKVVEHTLKIKPEFSTSGGTSDARFVKNYCPLVEFGLLSETAHKINEYTKISDLQKLYDVYYNFLMEIL
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: PCKA_AGARV
Sequence: MANVDLTKYGITGTTEIVHNPSYETLFEEETKAGLEGYEVGKETELGAVNVMTGIYTGRSPKDKYIVMDENSKDTVWWNTPEYPNDNHPMKEDVWATVKDLAKKELCNKKLFVVDAFCGANKDTRMAVRFIVEVAWQAHFVTNMFIQPSAEELENFEPDFVVYNASKAKVENYKELGLNSETCVAFNITSKEQVIINTWYGGEMKKGMFSMMNYYLPLKGIASMHCSANADMNGENTAIFFGLSGTGKTTLSTDPKRLLIGDDEHGWDDNGVFNFEGGCYAKVIGLDKESEPDIYNAIRRDALLENVTVADDGKIDFEDKSVTENTRVSYPINHITNIVKPVSSAPAAKNVIFLSADAFGVLPPVSILTPEQTQYYFLSGFTAKLAGTERGITEPTPTFSACFGQAFLELHPTKYAAELVKKMEKSGAKAYLVNTGWNGTGKRITIKDTRGIIDAILSGDILNAPTKKIPMFDFEVPTELPGVDSGILDPRDTYADASEWEAKAKDLAERFNKNFVKYTTNEAGKALVAAGPQL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUSA_ECO24
Sequence: MNTYSITLPWPPSNNRYYRHNRGRTHVSAEGQAYRDNVARIIKNAMLDIGLAMPVKIRIECHMPDRCRRDLDNLQKAAFDALTKAGFWLDDELVVDYRVVKMPVTKGGKLELTITELGDE
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair.  Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides.  Corrects the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC (By similarity).
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RusA, Holliday junction nuclease RusA, Holliday junction resolvase.
What is the protein family that this protein belongs to?
Belongs to the RusA family.
Protein: PYRG_KLEP3
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMTRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLAGGEGHDVVLVEIGGTVGDIESLPFLEAIRQMAVEIGREHTLFMHLTLVPYMAAAGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLLKSQGLDDYICKRFSLTCPEANLAEWEQVIYEEANPAGEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVTVNIKLIDSQDVETRGVEILKDLDAILIPGGFGYRGVEGKIATARYARENNIPYLGICLGMQVALIEFARNVAGMENANSTEFVPDCKYPVVALITEWRDEDGNVEVRSEKSDLGGTMRLGAQQCQLDDESLVRQLYGEPTITERHRHRYEVNNMLLKPIEAAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAASEYQKRQAK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: METK_CLOBL
Sequence: MRKLFTSESVTEGHPDKICDQISDAVLDAILDKDPNGRVACETAVTTGMVMVMGEISTKCYVDIPKLVRETIRGIGYDRAKYGFDCETCSVITSIDEQSVDIAMGVDEALESKKGEMDRLDAVGAGDQGMMFGFATNETKEYMPMPIEMAHKLSRRLSEVRKNGTLPYLRPDGKTQVTVEYENGKPVRIDAIVISTQHGPEVYLEQIEKDIKEHVIKVIVPSELLDENTKYFINPTGRFVVGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGVADKLEIQLAYAIGVAKPVSISVDTFGTGKMTDEEIVSIVNKVFDLRPGAIIRDLDLRRPIYKQVAAYGHFGRTDIDVPWERLDKVEEIKKHI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAR16_RAT
Sequence: MQLSNRAAARESVSRDVLAADLRCSLFASALQSYKRDSVLRPFPASYARHDCKDFEALLADTGRLPNLKELLQSSRDTDKQTWDLVSWILSSKILTIHSAEKAEFEKIQQLTGAPHTPVPIPDFLFEIEYFDPANARFYETKGGRDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGRGWQHSLLGQTLSCVAVCEVIDHPDVKCQTKKKDSKEIDRSRARIKHSEGGDVPPKYFVVTNNQLLRVKYLLVYSQKQPKRASSQLSWLCSHWFMVAMSLYLLLLLIVSVTNSSAFQHFWNRLKR
What is the function of this protein?
Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes.  Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading.  Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2.  Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors.  May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor.  May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases.
What are the official names of this protein?
Protein mono-ADP-ribosyltransferase PARP16, ADP-ribosyltransferase diphtheria toxin-like 15, Poly [ADP-ribose] polymerase 16, PARP-16.
What is the protein family that this protein belongs to?
Belongs to the ARTD/PARP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Protein: RPOZ_BACC2
Sequence: MLNPSIDSLLQKIDSKYTLVTVAAKRAREMQLANNCVVEQPVSHKCVGKALEEIDAEVLSYVPSEDKVAE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RPOC_PSYA2
Sequence: MKDLLDIMQSPTSNGNHEFDSIQITLASPDVIKSWSHGEVKKPETINYRTFKPERDGLFCAKIFGPVKDFECLCGKYKRRKFQGVICEKCGVEVTTAKVRRDRMGHIDLASPVAHIWFLKSLPSRIGLLLDMTLRDIERVLYFESYIVTEPGLTSLEKYQLLDDEDYYKALEEFGDEFTAKMGAEAVQDLLKDIDLDLEIDELREAIPQTGSETKLKKMSKRLKLLEAFRNSNNKPEWMVMNILPVLPPDLRPLVPLEGGRFATSDLNDLYRRVINRNNRLKRLLELSAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPTLRLHQCGLPKKMALELFKPFTYNKLLSHGLATTIKAAKKMVEREEPQVWDMLAMVIREHPVLLNRAPTLHRLGLQAFEPVLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLTLEAQLESRALMMSTNNILSPANGEPIIVPSQDVVLGLYYISRSSVNAKGEGMIFATVNEALRAIGSNDLHVNAKIKVRVTETHIDDDGNRTKETSIKDTVAGRLLIWNIMPVGMSFDECNEEMTKKNISKLINSCYRKVGVKESVMFADQLMYLGFAQATLSGVSIGIDDMVIPPLKKQIIEVAEAEVREIEDQFEQGFVTAGERYNKVVDIWSRTNDKVAKAMMDNLATDKIINAKGEEEEQKSFNSIFIMSDSGARGSAAQIRQLAGMRGLMAKPDGSIIETPIKANFREGLTVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVITSDDCGTEQGLLMKPHIQGGEIIEKLGELVLGRVTARDVTYNDDAEKILIPAGTLIDEHWVKVLDNNAIDDIWARSVITCEIEHGVCSQCYGRDLARGHKVNIGESVGVMAAQSIGEPGTQLTMRTFHVGGAASSASVDNSISVRSAGQAHFENMKTVQHTDGHLVIVSRSAEIALTDELGRERERYKVPYGSSVLIKDEEQVEGGQTIAKWDPHTHPIITEFAGTARFSEITDGLTATVKVDDATGMSSFEILATRDRSSSAKDLRPAIILNTDEGKEVIYFLPAETIIRVSDGEKVAAGSILGRVPQASSGTKDITGGLPRVADLFEARRPKDHAIMAEMSGVVSFGKETKGKNRFIITNEDGEIHEELIPKWRQINVFENETVARGEVIADGPQNPHDILRLKGQTALADYIVNEVQDVYRLQGVKINDKHIEVIIRQMLRKVEITDGGDSNHFKGDQVEYADIKALNAKLEAEDKFPVQFERQLLGITKASLATESFISAASFQETTRVLTAAAVTGKVDELRGLKENVVVGRLIPAGTGLAYHKARKEKAEQKLQDKDLNAAFDMSATTDSKDFASFDEAFAQELNQGNH
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: MED30_DROPS
Sequence: MWKYGQNQGNQGPAGGGGGAPNMMPMGGFMQGGGGMQGGGGMQHGNMPQMHMTPQQQQQQQQMNMMGGPGGMQMNPNAVGPTGLMPGMSPQHQMQQQQQMMQGVPMSMPPQQAMQQQMMGPQQGLGMGGSSGPQQQQQLQQQQQQSNLQQQQQQHNVGSGGAPGAGGVGNNMLAISQPNPHKEINIVQLSRLGQETVQDIASRFQEVFSALKNIQPTSHRDNNTEKKVQEYFRTIRLLFKRVRIIYDKCNDAVMDYMNAESLIPYKDEPEPRIETSQCDEYRKVLQENHEYIETVKLKNRQLREIIDRTRIIIWEINTMLAMRRS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 30, Mediator complex subunit 30.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 30 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SUV2_ARATH
Sequence: MSGNDEEFNDEFLLAIDSIETTLKKADMYRPLPPPYLPTFLPAPPPSTKISSSLSHPMQLQSSAGQQRKQIQVPDPFLSYSPPRELSQRVVSGFNDALMDYSNSTVVTAAKPISPTTSNRRCDSEKDLEIDRLKKELERVSKQLLDVEQECSQLKKGKSKETESRNLCADDNRGQCSTVHASKRIDLEPDVATSSVNHRENDSRMALDDKRSFKTTGVQADVANHSDLSKKLLDIWRTSNYQDPRKNLISELLLACSTDLQILFSFMKISTPPQELNKQEAKTSSDRQSSKALESEKVYQLYSAVTKISYGFVNLKTLVEPLLDLCKAETAVLVHRSLRVLHVLLEHICGDEKRFEASWDANWHSLFKLMNQIASKRTEQDVKQEALSIMNIIVMSTDAYTARESFVSKEVFESISLLLRKEGGLHVRKEAIHLFYLLLNCPKLYDTFDSLHEEKNSSDTENDSEGNFFALEAFGKIFEGLADCLTSPRKTSEDLELCRNVIMILALAASSGNSGYELLSSHKLPQDSSFLMLILHLLVAEIDSESTEFHPKAEIFKARTLLMREILILLNRLVSGLSSSATILKELTTSRDMASLTVDAATRLSRKRNLLGKPESSVERMRNTEIMDLARIFKKRVFAFLGDNTI
What is the function of this protein?
Required for tolerance to DNA-damaging and cross-linking agents such as UVB irradiation, gamma-radiation, aphidicolin, ionizing radiation and hydroxyurea (HU), cisplatin (CDDP) and mitomycin C (MMC) (PubMed:19619159, PubMed:19619158, PubMed:28556304).  Involved in cell-cycle G2/M arrest in response to DNA damage (PubMed:19619159, PubMed:19619158).  Required for aluminum-dependent gene regulation and root growth inhibition in an ATR-dependent manner by halting cell cycle progression and triggering loss of the quiescent center (QC) (PubMed:28556304).
What are the official names of this protein?
Protein SENSITIVE TO UV 2, ATR interacting protein, AtATRIP, Protein HYDROXYUREA-SENSITIVE 2.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ZNT6_MOUSE
Sequence: MGTIHLFRKPQRSFFGKLLQEFRLVAADRRSWKILLFGAINVLCTGFLLMWCSSTNSIALTAYTYLTIFDLFSLITCLISYWVMMRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALSFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGLIPGLSSIFLPRMNPFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVSNRLCTLVSTLTVQIFKDDWIRPALSSGPVAPNVLNFSDHHVIPMPLLKNVDERTPVTSTPAKPSSPPPEFSFNTPGKNVSPVILLNTQTRPYSLGLNRGHTPYSSVFSQGLAFPGVGAGQGLRPTFPHIPSRYGINRMGQPRP
What is the function of this protein?
Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (Probable).  As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (By similarity).
What are the official names of this protein?
Zinc transporter 6, ZnT-6, Solute carrier family 30 member 6.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Protein: SRCA_CHICK
Sequence: MKRLNLLCCCVASLLLLGTAEEVEDASEPTKRDRSHLENTLKLNEDKPADDFSGVLQRLRKIYHASIKPLEQSYRYNELRQHEITDGEITSKPMVLFLGPWSVGKSSMINYLLGLDDTPYQLYTGAEPTTSEFTVIMHGPKLKTIEGIVMAADSARSFSPLEKFGQNFLEKLIGIEVPHKLLERVTFVDTPGIIENRKQQERGYPFNDVCQWFIDRADLIFVVFDPTKLDVGLELEMLFRQLKGRESQIRIILNKADSLATQELMRVYGALFWSLAPLINVTEPPRVYVSSFWPHEYHPDTHKDLFLKEEISLLEDLNQVIENRMENKIAFIRQHAIRVRIHALLVDRYLQTYKDKMTFFSDGELVFRDIVEDPDKFFIFKSILAKTNVSKFDLPNREAYKDFFGINPITSFKLLSQQCSYMGGCYLEKIEKAITRELPDLLGSIGLGKKPNVLSCDVTGCGETPKNRYKKP
What are the official names of this protein?
Sarcalumenin.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein. Note=May associate with the sarcoplasmic reticulum membrane, via a calcium-dependent mechanism.