PharMolix/UniProtQA huggingface dataset:
Protein: RLMD_PSEAB
Sequence: MARNKGGLRFQPSGGARGPAIPVGKKQRLTIERLAHDGRGIAHEAGMTWFVSGGLPGEELEARVLGARSKVVDARSERLFSSSDLRRREPCTVAGRCGGCTLQHLEHGEQLALKQRTLQEQLQRFAGIEPEEWAAPLVGPEFGYRRRARIAVRWDARARRLDVGFRASASQEIVAFDECLVLVPPLQTIARALPALLQDFRKPESIGHVELFHGTASALLLRHTTALVDEDRQRLAAFCSAHQAQLWLQGAEQPLPVEPAAELGYSLGDWQLTLAYRPGDFVQVNAPVNESMIRQALDWLAPTADERVLDLFCGLGNFSLPLARRVARVVGVEGVAAMVERAGANALANGLGNAHFFQADLSKALAEAPWAEQGFTAVLLDPPRDGAFEAVREMSSLGARRVVYVSCNPATLARDAGEMARQGYRLKRAGILDMFPQTAHVEAMALFEAG
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: PHNW_PSEPW
Sequence: MSNAPILLTPGPLTTSLRTRQAMLVDWGSWDRDFNQLTASVCEQLLAIIDGSASHHCVPLQGSGTFAVEAAIGTLVPRDGKVLVLINGAYGQRLAKICKVLGRNFSTFETAEDQPTTAADVDRLLAADPSVTHVALIHCETSTGILNPLHEIAQVIKRHGKRLIIDAMSSFGALPIDAREIPFEALIAASGKCLEGVPGMGFVFAEKTALAAAEGNAHSLAMDLHDQHAYMAKTGQWRFTPPTHVIAALHEALLQYAEEGGLPARHQRYADNCKTLLDGMAAIGLRSFLPADIQAPIIVTFHAPNDARYQFKDFYERVKAKGFILYPGKLTQVETFRVGCIGVVGPDGMQAAVNAVADVLREMEVLDI
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase, 2-aminoethylphosphonate aminotransferase, AEP transaminase, AEPT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: METK_SYNP2
Sequence: MSRRYLFTSESVTEGHPDKICDQISDAILDAVLAADPSSRVAAEVVTNTGLVLITGELTTQANVNFIQVARQKIKEIGYTNADNGFSANSCSVMVALDEQSPDIAQGVTSAQEQRDKLSDDQLDEIGAGDQGLMFGYACNETPEFMPLPISLAHRLSLKLSQVRKSGELPYLGPDGKTQVTVIYEDGKPVGIDTILISTQHTETIGALTDNTEIQAKIKADLLEKVIKPVFVGATVGLSDSTKFLVNPTGKFVIGGPQGDSGLTGRKIIIDTYGGYSRHGGGAFSGKDPTKVDRSASYACRYVAKNIVAAGLAEKCEVQVSYAIGVARPVSVMIETFGTCTVDEDRLLEVVQKHFELRPAGIIQAFDLRNLPSQRNGRFYQDMAAYGHFGRTDLDLPWERLDKVDILKQELATATVA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHB8_CANLF
Sequence: MASPLRLRSALALVTGAGSGIGRAVSVRLAKEGATVAACDLDRAAACETVWLLGGQGSEKVAPGGAHTAFQADVSEAGAVRRLLEQVQACFSRPPSVVVSCAGLTRDEFLLRMSEDDWDRVIAVNLKGIFLVTQAAAQALVSSGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFITTPMTQKVPQKVLDKVIGMIPMGHLGDPEDVADAVTFLASEDSGYITGASVEVTGGLYM
What is the function of this protein?
Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS).  Alpha-subunit of the KAR complex that acts as scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis.  Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function.  Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+).  Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters.  NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2).  Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one).  Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol.
What are the official names of this protein?
(3R)-3-hydroxyacyl-CoA dehydrogenase, 17-beta-hydroxysteroid dehydrogenase 8, 17-beta-HSD 8, 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit, KAR alpha subunit, 3-oxoacyl-[acyl-carrier-protein] reductase, Estradiol 17-beta-dehydrogenase 8, Testosterone 17-beta-dehydrogenase 8.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CY561_HUMAN
Sequence: MEGGAAAATPTALPYYVAFSQLLGLTLVAMTGAWLGLYRGGIAWESDLQFNAHPLCMVIGLIFLQGNALLVYRVFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLFNLGGKYSAFEPEGVLANVLGLLLACFGGAVLYILTRADWKRPSQAEEQALSMDFKTLTEGDSPGSQ
What is the function of this protein?
Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles.  It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes.
What are the official names of this protein?
Transmembrane ascorbate-dependent reductase CYB561, Cytochrome b-561, Cytochrome b561.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Multi-pass membrane protein. Note=Secretory vesicle containing catecholamines and amidated peptides.
Protein: NIPA2_HUMAN
Sequence: MSQGRGKYDFYIGLGLAMSSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVSFRKDEKAMNGNLSNMYEVLNNNEESLTCGIEQHTGENVSRRNGNLTAF
What is the function of this protein?
Acts as a selective Mg(2+) transporter.
What are the official names of this protein?
Magnesium transporter NIPA2, Non-imprinted in Prader-Willi/Angelman syndrome region protein 2.
What is the protein family that this protein belongs to?
Belongs to the NIPA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Recruited to the cell membrane in response to low extracellular magnesium.
Protein: SSTT_ACIBC
Sequence: MLEFFSRLSLVTKIIIAIILGIGVALLFPTVTPYLSLFGELFIKALKSVAPILVFVLVLSSIANFQVGHSANLRPVLLLYVVGMLLAAFSAVIASLSFPSTLYLNTVSHNNLQAPGSLADILKNLLLSFIANPVQAISEANFIGILAWAIGLGLAMRHSSDTTKQVMQDVSHAVSAIIHKVIAFAPVGIFGLVAVTFADAGLATLESYAQLLAVLLGTMLFVALVINPILVGLTIRGNPYPLVFKCLKESGITAFFTRSSAANIPVNLDLAERLGVNPSTASVSIPLGATVNMAGAAVTITVLTLATVHTLGIHVDLATMIILSIVATISACGASGVAGGSLLLIPVACSLFGISSEIAMQVVAVGMIISVLQDSTETALNSSTDVLFTAAVDIRSRQNS
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL10_SHIBS
Sequence: MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRAVEGTPFECLKDAFVGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELIPASQIDRLATLPTYEEAIARLMATMKEASAGKLVRTLAAVRDAKEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y324_TREPA
Sequence: MAVLPSVRRFECSLFVVLVLCALAVFDPLSGFVQQKLAGVQRVWLGLVEEYSGLRFQYDSLSPSVLRAVTLRNVRVREAVRGEQVAVFSKIVVAYNIFSLFGSNPVRGIRALHVHDGAVDVDLYRHRHVKEKLQKLFSKDGEMASFFADLREIDVRVHNTAVTVRSDSRRAHLSVPQGRFSFAETGASFALSCEAEYVDTRSSSWGPLYTHLDASGVFETSFTSGSATLELAPPSGSFFSVPTLTLVAIYADDLFKFHTARGIYPMEVSGQWNTATGACEASVRCENFRPLKWARLRDTHVPAQGMQELSVSGNVQVGYTPIEQWRWSADVHAHTPYVVLAPGYQLEDVVATLQAHGDPARIQVEKICARGSNLDVDGAFELTLDRWIPSGVLTVHRLPLLSGAYLSAQVRFRPQGVGFVCTVPRIQVGEAFLEDVALSVRVDPAKTDFRLVAADSTGRYECDGSYLAANAGSLAFLRHTWRLNR
What are the official names of this protein?
Uncharacterized protein TP_0324.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y1315_HAEIN
Sequence: MLVDMGEQYMLTTILSFLIVTTVVAYVSWLKTKGDDLKSSKGYFLAGRGLSGLVIGCSMVLTSLSTEQLIGVNAVSYKGNFSVIAWTVPTVIPLCFLALYIIGWL
What are the official names of this protein?
Putative uncharacterized symporter HI_1315.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FABZ_CROS8
Sequence: MTTETHTLHIEEILELLPHRYPFLLVDRVLDFEEGRFLRAVKNVSVNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMVMEVTFEKTRRGVTRFKGVALVDGKVVCEATMMCARSREA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAR7_PACBA
Sequence: ARSDNFVRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-7, FMRFa-7.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAP_SCHPO
Sequence: MTTKQWGITPPISTAPATEQENALNTALINELKNQNLFESPAESEKRVKVLDELQQITTEFVKKVSLAKHMNEKMANEAGGKIFTYGSYRLGVYGPGSDIDTLVVVPKHVSRDNFFQDLEPMLREREEVTDLAAVPDAYVPIIKFKFLGISIDLIFARLSVPRVPRDLELSDNNLLKGVEERCVLSLNGTRVTDQILQLVPNRAVFKHALRAIKFWAQRRAIYANVVGFPGGVAWAMMVARICQLYPNAVSSVIVAKFFRILHQWNWPQPILLKPIEDGPLQVRIWNPKLYPSDKAHRMPIITPAYPSMCATHNITLSTQTIILREMVRAGEIADQIMVKALPWSALFQKHDFFHRYKHYLTITAAAKTAEAQLKWAGLVESKLRHLVTRLELVDAIALAHPFNKGFDKVYNCSSEEEAQQVASGVTLEVAYESTDHEKLANDTVNEEKADNTESKADGSENGEKQIFPVYTTTCYIGLELEKKKGHPIKRLDISWPTQEFYELCKKWDKYDDTLMNVFIKNTKNTALPDEVFEPGEERPKATKKRSTADTAHSTEQLKRQKVSTA
What is the function of this protein?
Polymerase that creates the 3'-poly(A) tail of mRNA's.  May acquire specificity through interaction with a cleavage and polyadenylation factor (CF I).
What are the official names of this protein?
Poly(A) polymerase pla1, PAP, Polynucleotide adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the poly(A) polymerase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNAA_BRASB
Sequence: MTNSEQERWSRVKGRLRSTVGEDVYTSWFARMDLEAVQDESVHLSVPTRFLKSWIQAHYAERVLSCWQAEMPEVHRIDLSVRTAMRCATPAKEAPVAVEARRAERGDAKPADTRAPVMTPVAASHDALGGSPLDPRLTFASFVVGRANTLAHAAARQVADGRRGDPVMFNPLYIHAGVGLGKTHLLQAVTWAGNAGGERKVLYLTAEKFMYGFVAALKSQTALAFKEALRGIDVLVIDDLQFLQGKSTQAEFCHTLNALIDAGRQVVIAADRPPSDLESLDDRVRSRLAGGLVVEMATLGEDLRLGILKSRVAAARAHHASFDVPEPVLDYLARSITHNGRDLEGAINRLLAHSKLNNQPVTLDMAEREVRDLVRPQEPKRIKIEDIQRVVARQYNVSRSDLLSSRRTANVVRPRQVAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIEALVGKDTTLNDEVEALKRQLQD
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTKL_PLABA
Sequence: MGNINSIQTKNYIKFEKYYYAGDLNVDNLPHGRGLMLYENGNSFFGHFINGKKHGKGIYIDKNLTKYISKWKYDHISNKVKVKQFDSDIVYLFYYKNGLIDHCKVYEYISNKKKKKKKKNDGILEDSEIQNRSINFEKDNIMIIQNCQEKSIVNKKEEIIDIPNNKYNENDDTDKVDNFSKKINLEQSQNNMLKYKKKKTFDEMNSLNDSIFCSSCESTSKSIGSDYISHFEKKEKQINKQEDELKKSKENYMNHSEYSNSSTNFENNKIKDISDESIMLRLKNIINNNTDLKIENYELWNKEQVAQWLSLCNVPMKWALSVYKNNINGQRLNNLNLYFIRNKLGILSYGQAIKFLQLIKNLRVTAYNTRFSNTLNLEEYEIYLKKKMKKKKMRENKDGEYTATTSSQAEDFQKNNQKIIMNQIKSMIDQKNDDDKSFSDKIKNGFFKGNTNIRNLQNLVINSIWNKSKDEFKIPIDENNVPMNIEKGKELNTNDQITGKKKKKLKNKYINHIQKNISMLKKLNNASNESQSSNESVTQILSTSSESSFANIHSGLSSKMLFHDKLEPEPIKPNKEKEENNPNLSPIINSKNETNLLNDSNPTKLQDELPKSPCSIDSESSSEKSSETSSETSSFCSEHSEFANFHNNNKIVKYSNNIYINSSLAFSYIYSFIIPPENLTFLYQIRNYYVRDVENDLNPNNELDFCDSFNFYKNCEIIKNRIINPGIRNCSYASNHSKFQQNKNRKYFNYSDCKNERKKTKPQKMKSRVFRGRYMGKDVAIKVLVGNIKNFTKFHKVLYKLYILRHTNIALIMGVSISYPFVFIIYEYIKNLCLFSYLHCVKYKHIYVSKLLKYYQKKFINQNFQQQNNTMSSDRKYISNDDNEKINFDSRNILRNKLLEIKCKNNAKNKITEKNNLKDEQIYSSSTSIKSLDTSSSNMNNTKLKNINFNKNRYINKIHSMFRNKNNILCGNYYYLFRKKKNNISISHEHKNSDRTIFTNESQNLLKNKISQKKINKKLNFKAKIKINRPYAFPPLQEDFNFYLEKKKKKKKILFSYLKTHSYFKSKKCDSRKNKLSDHQIMKIIMDITLACSYLEKQKVRWINLKPTNILLDGSLNAKISDFGIKEIEQCLDINIDYSYIVFPNNVIKFNNKHFKNKIKKIKIVNKGSEDMLHVFSSKNHIYKYNTREINVSSNTHNSSVFFWTSPEILKGKQSPSLYSDVYAYGIILWELMTNSVPFNYRFKSHLLASVGYAKESLPFQNIPPFIKNLIKSCINRNKYKRPTFDRILIEISMIYEQINPKEEDALMSFMDG
What are the official names of this protein?
Inactive protein tyrosine kinase pTKL, PbpTKL, Pseudo-tyrosine kinase-like protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Parasitophorous vacuole. Host cell membrane; Peripheral membrane protein. Host cytoplasm, host cytoskeleton. Host cytoplasm. Note=During the trophozoite stages, secreted into the parasitophorous vacuole and into the host erythrocyte cytoplasm (PubMed:31148576). At the schizont stage, localizes to the parasitophorous vacuole but not to the host erythrocyte cytoplasm (PubMed:31148576).
Protein: INSL1_DROME
Sequence: MFSQHNGAAVHGLRLQSLLIAAMLTAAMAMVTPTGSGHQLLPPGNHKLCGPALSDAMDVVCPHGFNTLPRKRESLLGNSDDDEDTEQEVQDDSSMWQTLDGAGYSFSPLLTNLYGSEVLIKMRRHRRHLTGGVYDECCVKTCSYLELAIYCLPK
What are the official names of this protein?
Probable insulin-like peptide 1, dILP1, Insulin-related peptide 1.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RUTC_CAUST
Sequence: MPKTVITPPGTGTPIAPFSPGTLADGIVYVSGTLAFDKDNNVAFPGDAEAQTRQVLETIKSVIETAGGTMEDVVMNHIFLTDWVHYAPMNKVYAEYFPGDKPARYCIQCGLVKPGFVVEIASVAHIGKP
What is the function of this protein?
Involved in pyrimidine catabolism.  Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously.  RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.
What are the official names of this protein?
3-aminoacrylate deaminase RutC, 3-AA deaminase.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: HFLK_BUCAP
Sequence: MAWNKFNNSEPELDPWGKKNSQEKNGSKNKDDRKNHEKIITLDFKKFLYNINNIFNKTNNSQNLSKNKINPFLIIAFVSFFVWCFSGFYTIKEAERGVVTTFGKFSHLVAPGLNWRPVFINEVKAVNVETVRELATSGVMLTSDENVVRVEMNVQYKITDPADYLFSVAYPDDSLRQATDSALRGVIGHSNMDRVLTEGRTLIRSDTQKEIEETIKPYKLGITILDVNFQTARPPEEVKEAFDDAIAARENREQYIREAEAYSNEVQPKAHGKAQRILEEAKAYSSRRILEAQGEVVRFLKILPEYRKNKEMTLKRLYIESMEKLLSKTKKIFIDKKNHSKLFLSLNNFFHQDKFNKQDLFNNPINLSKNHSCSFQKNKEINDVSSLPPSDFFKKRRIESIRTNIKNIERE
What is the function of this protein?
HflC and HflK could encode or regulate a protease.
What are the official names of this protein?
Protein HflK.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family. HflK subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CTAA_RHOPB
Sequence: MPAVPADRPMHAVRIWLAIIAGLIAVMVLVGGATRLTESGLSIVEWKPITGTLPPLSVEQWTQAFDAYKTIPQYRELNAGMTLAQFKTIFWWEWSHRLLGRVIGAAFLLPFLWFLWRGDLGGGLKRRLWIIFGLGALQGAVGWWMVASGLSQRVEVSQVRLATHLVLALLIFAGIVWTLRQLTPRPAIVAPLRLRLTAAVLLGLTFVQLYLGALVAGLRAGRIYNTWPQIDGALIPSAARLWFEQPWWKNLFDNHLTVQFDHRMLAYALWALAVLHAIDAWRARAAAGGALALAVAITLQAALGIVTLLYAVPIGLGLAHQAMAILVLTLAVLQLARFSPGVVQTAQHAAAPSLGQPAQGRG
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM3_BORPE
Sequence: MAAVERLTIATRASRLALWQAEHVRDLLRARYPACSVELLTLTTRGDQILDRTLSKVGGKGLFVKELETALLDGRADLAVHSLKDVPVDLHAPFELSCVLERADPRDAFVSNDYGSLADLPPGAAVGTSSLRRESQIRARYPHLVVKPLRGNLDTRLGKLDNGDYAAIVLAAAGLERLGLAARIRALLEPDDSLPAAGQGALGIEILQGRADVRAMLAPLGDAATLACVTAERAVSRMLGGSCQVPLAAYARIDGDELALRALVAAPDGRRIVRAERRGPRDQAQAIGESAARDLLADGADAILAELLPTSPAP
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PCL6_YEAST
Sequence: MSIKGDSPSSTNASSSPKSTYSIQSDDKANLGSGNVDIRTDNSQQDSNNRRDIVVVTRVASEETLESQSSTSSMGIRPESSFNYEDASNQARVEMNNRVHGSNMNTINKYYPVRFPKNNERQLSDTNNLNEKVQGTHTVQSSTQEDKILDGDTSNSQVTPSLNIAEFPTDKLLKMLTALLTKIIKSNDRTAATNPSLTQEIENGRCLALSDNEKKYLSPVLGFRGKHVPQIGLDQYFQRIQKYCPTTNDVFLSLLVYFDRISKRCNSVTTTPKTNTAKHESPSNESSLDKANRGADKMSACNSNENNENDDSDDENTGVQRDSRAHPQMFVMDSHNIHRLIIAGITVSTKFLSDFFYSNSRYSRVGGISLQELNHLELQFLVLCDFELLISVNELQRYADLLYRFWNNAKAQSQALVTGM
What is the function of this protein?
Cyclin partner of the cyclin-dependent kinase (CDK) PHO85.  Together with cyclin PCL7, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility.  The PCL6-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase.  PCL6-PHO85 also phosphorylates YJL084C.
What are the official names of this protein?
PHO85 cyclin-6.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. PHO80 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LEU3_SACD2
Sequence: MSKKIVLLPGDGIGPEIVAEAKKVLEAVDAKFKLGLKFEEDLIGGCAIDVHGVPLAQSTLDRCKAADAVLMGSVGGPKWDALDSNIRPEKGLLKIRYEMGLYANLRPAILYPQLADASSLKPEIVSGLDILIVRELTGGIYFGEPRGIRLLDNGERQGYNTYVYAEHEIERIGRTAFEMAMKRDKKVCSVDKANVLEATVLWREVIQSISKDYPEVELSHMYVDNAAMQLVRAPKQFDVVVTGNMFGDILSDTAAMLTGSIGMLPSASLNQDSKGLYEPVHGSAPDIAGQGVANPLATILSAAMMLRYSLNEAAAADAIEAAVGAVLDDGLRSADIFSEGMKKVSTQEMGDAVAAKI
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HGH1_SCHPO
Sequence: MSELIELVGFLHDQNPQVRMLAVQHLLPYTARNHPQFSIWFHNDFEPVKDLKALLKDKPQIASQAVTALVNVSQNEKVRKVLMDDEFLQLIFSIVTNPLHGLADLSCMLLCNLAKEEDFARILDMQVPLREFSLSKNIIDQLMDLFVKGTDHGINEYANFDFLANVFADMTRFERGRKYFTTLQEYDHVIPASKLVVFTEHKSLLRRTGVAAIIKNISFDIPFQKVLMDEEGINVLPYLLLPLAGPEELSEEDMDGMFDELQLLPDDKKREPDHFIMKTLVETLVLLTATREGREHMRRRKVYPIIRELHLNVDDEEIREVCDQLVQMLVRDEAPEELEHIQDNPPDEDDVIVEVD
What are the official names of this protein?
Protein HGH1 homolog.
What is the protein family that this protein belongs to?
Belongs to the HGH1 family.
Protein: RIBB_SALTI
Sequence: MNQTLLSSFGTPFERVELALDALREGRGVMVLDDEDRENEGDMIFPAETMTVEQMALTIRHGSGIVCLCITEDRRKQLDLPMMVENNTSAYGTGFTVTIEAAEGVTTGVSAADRVTTVRAAIKDGAKPSDLNRPGHVFPLRAQAGGVLTRGGHTEATIDLMTLAGFKPAGVLCELTNDDGTMARAPECIAFAGQHNMAVVTIEDLVAYRQAHERKAS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: DPTOR_MOUSE
Sequence: MEEGSSGGSGSSDSNAGGSGGVQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFALDSEVKAFMRGQRLYEKLMSPETTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMDHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNETSPSSQETHDSPFCLRKQSHDSRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLNVDYRTVSNLILTGPRTIVMEVMEELDC
What is the function of this protein?
Negative regulator of the mTORC1 and mTORC2 signaling pathways.  Inhibits the kinase activity of both complexes (By similarity).
What are the official names of this protein?
DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6.
Protein: YO012_YEAST
Sequence: MVASSINEESSLAVNLTSDVEKASKTLFKAFEKSYANDYLMKKFFHIPITEKVSRARINAMIHYYTTCYHDLDGEIAEANDFDAVAIWSRPGCHLPATLSDDESFNKIFFSRLDCEEARSHASGNGLLLPLCHRKRS
What are the official names of this protein?
Uncharacterized protein YOR012W.
Protein: ATP6_SALG2
Sequence: MASENMTPQEYIGHHLNNLQLDLRTFSLVDPQNPPATFWTLNIDSMFFSVVLGLLFLVMFRSVAKKATSGVPGKFQTAIELIVGFVHGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHWLGLPATRVVPSADVNITLSMALGVFILILFYSIKMKGIGGFAKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PETL_LIRTU
Sequence: MSTITSYFGFLLAASTITPALLIGLSKIRLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.