PharMolix/UniProtQA huggingface dataset:
Protein: COQ4_TALSN
Sequence: MPPTPRTALLTVSNRCLQCHEIGLKYSFRSFSALNRPPPSYPGHVPLTRIERGVLAIGSAFGSLLNPRRHDLIAALGEATATPYFIYRLRDAMLSSPTGRRILRDRPRLTSETLKLPYLRSLPENSVGRTYAKWLDREGVSPDTRDSVQYIDDEECAYVMQRYRECHDFYHAVTGLPTMVEGELALKAFEFLNTVIPMTGLSLAAAIRLKPAERERFFKLHLPWAVRSGLSSEELINVYWEEQLERNVDELRAELGIEAPPDLREIRRMMRQQEKRAKEQQMKASGL
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein coq4, mitochondrial, Coenzyme Q biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: PDH3_LEUMG
Sequence: MLPRVARLNTHLVSLALLGFQITYGAITYQHPDDLPSDVDYDFIVAGGGTAGLVVASRLSENPDWNILVIEAGPSNKDAPETRVPGLAGSLPASRTDWNYTTIPQDALGGRSLNYSRAKVLGGCSSHNSMVYTRGSKDDWNHWADITGDQGLSWDSILPVMKKAEKFSKDFSNQSVDGHIDPSMHGHDGLLSVVSSYTNVSFNDLLLETTKELSDEFPFKLDLNDGNPHGLAWTQYTIDHRAERSSSATSYLESTRDNVHVLVNSRVTRIFSAGNGTDFRSVEFAVDANSPKKVLTAKKEVILSAGVIASPQVLMNSGIGGREELQAIGVDTLIDNPSVGKNLSDQAATLLMFDTTLPNTDYDVAAALTEWEDSRSGPMAYGARLNHLTWVRLLDDKLNGSDPSSGKNSPHIEFQFMQISHQLPPADAPNQVKLPDPDSIGAVLLLAVVNLYSVSHGSIILNDNDPFANPMIDLNMFGDQKDIAILREGVRSARRMFSSQAFKDVVNGTVYPPADVTSDEDLDAFLRTSAISYWHGVGTLSMSPQNASWGVVDPDFRVKGTSGLRVVDASVIPYAPAGHTQVPVYTFAEHASVLIAKSYA
What is the function of this protein?
Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin.  The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses to the corresponding C-1, C-2, C-3 or C-1,2, C-2,3 and C-3,4 (di)dehydro sugars with substrate-specific regioselectivity.  Accepts only a narrow range of electron acceptors such as substituted benzoquinones and complexed metal ions and reacts extremely slowly with O(2) as acceptor.  May play a role in the natural recycling of plant matter by oxidizing all major monosaccharides in lignocellulose and by reducing quinone compounds or reactive radical species generated during lignin depolymerization (By similarity).
What are the official names of this protein?
Pyranose dehydrogenase 3, PDH 3, Pyranose:quinone oxidoreductase 3.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSBQ_BACSU
Sequence: MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEEDHRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIGMLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFAATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCADDIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV
What is the function of this protein?
Positive regulator required for energy stress activation of the sigma-B transcription factor.  Could be required for RsbP phosphatase activity.
What are the official names of this protein?
Sigma factor SigB regulation protein RsbQ.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: MDM10_CANGA
Sequence: MLDYMDYVQQCFDSAGRWKRQNSYGEVTQTPRNLIDFKIPDAVNLQVSNRSTKYSYNSLQLSTRQSINGSLTYLYTNLDAVEGLVKNTEELPLHDIVQTYELPAVTHHRKEKTNFHKCSLFYGKIFYPSSDVEAMMIKRFSPMNQVIVKCLSSLKENVNIFTAYFQRNSEKNFQELIVSSNDLLCGYRISHHFLRTPSKLNSSLYNNSSLFFGAEFWLGMISLNPGCSTSLKYCTHSANTGRPLTLTLSWNPLFGHISTTYSAMTSSSSTFCAKYDFNIYSIESNLSFGIELWRKTGALFKSEDSVEANRKEYEQNFYISHDHNLLPSKYGYDHEYNISDGKLSKEHKRNKIIKDLNHAFSTSLQKIDKEKTRIENFGNIIRNSHFTSVFKASTSLRERNLKFLWEGEYKNFLLSAGTELRVLKAEESELRRTSGQSSNSLLNEFSLQPLKFGVQIQFSS
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component MDM10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: Y1077_BRUSI
Sequence: MSDKTPRKPTAFRLEQPARVSAASEQEEPRHPRAVKDLEQITPQADVFDLTDDEAAELEILDPAFEAPERKGWSLSRILFGALGILVSFAIGIWTEDLIRALFARADWLGWTALGVAMVALAAFAAIILRELVALRRLASVQHLRKDAADAAERDDMAAARKAVDALRTIAAGIPETAKGRQLLDSLTDDIIDGRDLIRLAETEILRPLDREARTLVLNASKRVSIVTAISTRALVDIGYVIFESARLIRRLSQLYGGRPGTLGFIKLARRVIAHLAVTGTIAMGDSVIQQLVGHGLASRLSAKLGEGVVNGLMTARIGIAAMDVVRPFPFNAEKRPGIGDFIGELARLNSDRNARK
What are the official names of this protein?
UPF0283 membrane protein BSUIS_A1077.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1204_ARCFU
Sequence: MFPADVILQCFGFSVGIALVGYVISLFLDWSEEEGDEDDA
What are the official names of this protein?
Uncharacterized protein AF_1204.
Protein: CCA_SHELP
Sequence: MKIYLVGGAVRDQLLNIPIKDRDYMVVGATVQEMLDKGYRQVGKDFPVFLHPKTQQEYALARTERKTGVGYGGFSVYAAPDVTLEEDLLRRDLTINAIAQDETGRVFDPYGGQADIEQRLLRHVSDAFVEDPLRVLRVARFAARFQPLGFKVAPETMALMQRIAASGELEALTPERVFQELDKALSTEAPQVFFEVLREAGGLAILFPEIEALFGIPQPEQWHPEIDTGIHTLMVLEQAARLSQDKQVRFAALVHDLGKALSPKEHLPKHHGHGQKGLPLIRALCERFRVPNDYRDLALLVSDQHQNIHNAFELRAETMVKLFDKADLWRKPERLPQLLLACEADCKGRTGLKERPYPQGAYVQHCFELARNVAIKPIIEAGFKGAEIKAQLHKQRVEVIDQYKRKTAVNAKP
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: HCHA_ECODH
Sequence: MTVQTSKNPQVDIAEDNAFFPSEYSLSQYTSPVSDLDGVDYPKPYRGKHKILVIAADERYLPTDNGKLFSTGNHPIETLLPLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMPFFEQHKSLFRNPKKLADVVASLNADSEYAAIFVPGGHGALIGLPESQDVAAALQWAIKNDRFVISLCHGPAAFLALRHGDNPLNGYSICAFPDAADKQTPEIGYMPGHLTWYFGEELKKMGMNIINDDITGRVHKDRKLLTGDSPFAANALGKLAAQEMLAAYAG
What is the function of this protein?
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals.  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals.  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE).  Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA.  Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair.  Plays an important role in protecting cells from carbonyl stress.
What are the official names of this protein?
Protein/nucleic acid deglycase HchA, Maillard deglycase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family. HchA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAA_SINFN
Sequence: MSIAAKDIEPGDIPGNLTGGEFSPYHVFSAEEWSRFRADTPLTLTGEEVKRLRSLNDPVDLGEVRRIYLSLSRLLSAHVEASQILFQQRKRFLSMSDETKTPFVIGIAGSVAVGKSTTARILAELLARWPSSPKVDLITTDGFLYPNAILQRDNMMDRKGFPESYDIGALLRFLSAIKAGRPNVKAPTYSHLTYDVIPDQFQLIDRPDILIFEGINVLQSRDLPADGKIVPMVSDFFDFSIYIDAEESLIHNWYVSRFMRLRETAFQNPQSFFHRYSTISEDAARAIAEGLWHNINLKNLHQNIQPTRPRADLILQKGPSHLTQTVALRKL
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC2_OLIPU
Sequence: MAERANLVFHNKVIDGTAIKRLISRLIDHFGMAYTSHILDQVKTLGFQQATATSISLGIDDLLTIPSKGWLVQDAEQQSWILEKHHHYGNVHAVEKLRQSIEIWYATSEYLRQEMNPNFRMTDPFNPVHMMSFSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGTIRGISVSPRNKNRMMSERIFIQTLIGRVLADDIYIGSRCVAFRNQDLGIGLVNRLITFGTQSISIRTPFTCRSTSWICRLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPYSGKIKFNEDLVHPTRTRHGHPAFLCYIDLSVIIESEDIIHSVTIPPKSFLLVQNDQYVESEQVIAEIREGTYTFHFKERVRKYIYSDSEGEMHWSTDVSHAPEFTYSNVHLLPKTSHLWILSGGSCGSSLIFFSIHKDQDQMNIPFLSVERKSISSLSVNNDQVSQKVLSSDFADQTKFGIPDYSEFKGNLGTSHYNFIYSAIFHENSDLLAKRRRNRFLIPFQSIQEQEKEFIPHSGISIEIPINGIFRRNSIFAFFDDPRYRRKSSGILKYGTPKADSIIQKADMIEYRGVQKFKTKYEMKVDRFFFIPEEVHILPESSAIMVQNYSIIGVDTRLALNIRSQVGGLIRVERKKKRIELKIFSGDIHFPDKTDKISRHSGILIPPGRGKKNSKESKKFQNWIYVQRITPTKKKFFVLVRPVATYEIADSINLATLFPQDLFREKDNIQLRVFNYILYGNSKPTQGISDTSIQLVRTCLVLNWDQDNKNSSLEEVRAFFVEVSTKGLIRDFIRIGLVKSHISYIRKRNNSRDSGLISADHMNPFYSISPKAGILQQSLRQNHGTIRMFLNRNKESQSLLILSSSNCFRMGPFNHLKYHNVINQSITKNPLITIKNSSGPLGTATQISNFYSFLPLLTYNKISLIKYLKLDNLKYIFQVINSYLIDENGKIFNLDPYSNVVLNPFKLNWYFLHQNYHHNYCEETSTIISLGQLFCENVCIAKKEPHLKSGQVLIVQRDSVVIRSAKPYLATPGAKVHGHYREILYEGDTLVTFIYEKSRSGDITQGLPKVEQVLEVRSIDSISLNLEKRIKGWNKCITRILGIPWGFLIGAELTIVQSRISLVNKIQKVYRSQGVQIHNRHIEIIVRQITSKVLVSEEGMSNVFLPGELIGLLRAERTGRALEESICYRAVLLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGVIPAGTGFNKGLVHCSRQHTNILLEKKTKNLSLFEGDMRDILFYHREFCDSAISKSAFSRI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RLMN_BACLD
Sequence: MESKQKVRKELRTERPSIYSFEIEELKSWLSENGEKPFRAAQIFEWLYEKRVTSFEKMTNLSKELRTKLNEHFVLTTLKTAVKQTSQDGTMKFLFELHDGYTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQQALDETDERVSSIVIMGIGEPFDNFQEMLAFLKIVNHDKGLNIGARHITVSTSGIIPKIYEFADEKLQINFAISLHAPNTEIRSRLMPINRAYKLPDLMKAVDYYIKKTGRRVTFEYGLFGGVNDQVEHAEELAELLKGIKCHVNLIPVNYVPERDYVRTPKEQIFAFEKTLKSHGVNVTIRREQGHDIDAACGQLRAKERQEETR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_PSEP1
Sequence: MSDRLTLLRPDDWHIHLRDGAVLPHTVGDVARTFARAIIMPNLVPPVRTANEAGAYRERILAARPAGSRFEPLMVLYLTDNISPEDIRAAKASGFVYAAKLYPAGATTNSDSGVTSIDNIFPAIEAMAEVGMPLLVHGEVTRSEIDVFDREKRFIDEHMRRVVERFPTLKVVFEHITTSDAAQFVTEAPANVGATITAQHLLYNRNHMLVGGIRPHFYCLPILKRNTHQVALLDAATSGNPKFFLGTDSAPHARHAKEAACGCAGCYTAYAAIEMYAEAFEQRNALDKLEGFASLHGPAFYGLPANTDTITLVREEWTAPESLPFGEQTVVPLRAGEKLRWRLLEKNA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: LAML3_XENLA
Sequence: MATSTPSRAREHASAAQSPGSPTRISRMQEKEDLRHLNDRLAAYIERVRSLEADKSLLKIQLEEREEVSSREVTNLRQLYETELADARKLLDQTANERARLQVELGKVREEYRQLQARNSKKENDLSLAQNQLRDLESKLNTKEAELATALSGKRGLEEQLQEQRAQIAGLESSLRDTTKQLHDEMLWRVDLENKMQTIREQLDFQKNIHTQEVKEIKKRHDTRIVEIDSGRRVEFESKLAEALQELRRDHEQQILEYKEHLEKNFSAKLENAQLAAAKNSDYASATREEIMATKLRVDTLSSQLNHYQKQNSALEAKVRDLQDMLDRAHDMHRRQMTEKDREVTEIRQTLQGQLEEYEQLLDVKLALDMEINAYRKMLEGEEQRLKLSPSPSQRSTVSRASTSQTSRLLRGKKRKLDETGRSVTKRSYKVVQQASSTGPVSVEDIDPEGNYVRLLNNTEEDFSLHGWVVKRMHMSLPEIAFKLPCRFILKSSQRVTIWAAGAGAVHSPPTDLVWKSQKTWGTGDNIKITLLDSTGEECAERTLYRVIGEEGETDEDFVEEEELERQFRSQSHQSVDPSCSIM
What is the function of this protein?
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
What are the official names of this protein?
Lamin-L(III), Lamin-B3.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.
Protein: RL36_ALIB4
Sequence: MKVRASVKKMCDKCKVIKRRGIVRVICENKKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: YYCI_BACSU
Sequence: MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVEHDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLKMKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQKTDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKEYSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTILDTDQ
What is the function of this protein?
Together with YycH, regulates the activity of the two-component system WalR/WalK.
What are the official names of this protein?
Two-component system WalR/WalK regulatory protein YycI.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ELO6_CAEEL
Sequence: MPQGEVSFFEVLTTAPFSHELSKKHIAQTQYAAFWISMAYVVVIFGLKAVMTNRKPFDLTGPLNLWNAGLAIFSTLGSLATTFGLLHEFFSRGFFESYIHIGDFYNGLSGMFTWLFVLSKVAEFGDTLFIILRKKPLMFLHWYHHVLTMNYAFMSFEANLGFNTWITWMNFSVHSIMYGYYMLRSFGVKVPAWIAKNITTMQILQFVITHFILFHVGYLAVTGQSVDSTPGYYWFCLLMEISYVVLFGNFYYQSYIKGGGKKFNAEKKTEKKIE
What is the function of this protein?
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle.  Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids.  Condensing enzyme required for the formation of isoheptadecanoate (C17iso), which plays critical roles in animal development and growth.
What are the official names of this protein?
Elongation of long chain fatty acids protein 6, ELO-6, 3-keto acyl-CoA synthase elo-6, Long-chain 3-oxoacyl-CoA synthase 6, CEELO6, Monomethyl branched-chain fatty acid elongase 6, mmBCFA elongase 6.
What is the protein family that this protein belongs to?
Belongs to the ELO family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PIG5_CLAP2
Sequence: MASTTGTEATPSRISLSQDHLGILHDVKVNTASIEIANSLLQKNHEEWHMFFRDRAGHNHISHSILTCLALGGSPEDIQRAYDDGLEIQRPMPPLDDALVARLGDDNVMYESLGSISQYRSFLAYFQHHMEEHGWKATVTKYLFSHTKLSEKMLARMYEGAYHPVIHLGLGFEFQQPAIVAEALAQAAAHDDSNLYTYFIACEEESEIAYPLQQAKTLLQIMADASSSKTIRNAPHWEDYGNKMRDGVLGRACRETANVASKFVIRKTPESLRRRTAEMIDTCAYVAASSQRSGRKRKIDFFYMHMVTSSLFFSVIGEQDWIPLNDRIRMVEWKARLDVAWYVVCGCADIQQLALTAYNDPVTDGMGWEELYAAVVKEHDDGHVSKMIRALKNGQEAARPFENGPYRNAFPLHGDMWLKAARMTLGTTTGCDEDTKFVMFTGFDIPWETRPDLQ
What is the function of this protein?
Baeyer-Villiger oxidase; part of the ergochrome gene cluster responsible for the typical purple-black color of the ergot sclerotia (PubMed:28955461).  The ergochrome gene cluster produces several ergot pigments including the yellow ergochrome secalonic acid and its derivatives, as well as the red anthraquinones endocrocin and clavorubin (PubMed:28955461).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) CPUR_05437 (By similarity).  The atrochrysone carboxyl ACP thioesterase CPUR_05436 then breaks the thioester bond and releases the atrochrysone carboxylic acid from CPUR_05437 (By similarity).  The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone (By similarity).  The next step is performed by the anthrone oxygenase CPUR_05434 that catalyzes the oxidation of emodinanthrone to emodin (By similarity).  Emodin is further modified to yield monodictyphenone via several steps involving CPUR_05427, CPUR_05428, CPUR_05429 and CPUR_05430 (By similarity).  The short chain dehydrogenase/reductase CPUR_05418 then catalyzes the C-5 ketoreduction to give the xanthone skeleton of the monomeric units (PubMed:32105084).  Ergochromes formation requires further dimerization steps of different xanthone units, probably catalyzed by the cytochrome P450 monooxygenase CPUR_05419 (PubMed:28955461).  CPUR_05425, CPUR_05426 and CPUR_05431 are unique to Claviceps, thus it is likely that they are involved in further modification of xanthone units or in their dimerization (PubMed:28955461).  The yellow ergochromes and the red anthraquinone pigments endocrocin and clavorubin are products from the same PKS derived precursors and the latter are likely shunt products in the pathway of xanthone biosynthesis (PubMed:28955461).  It is proposed that atrochrysone carboxylic acid released from the PKS CPUR_05437 can also0 be converted to endocrocin anthrone which is further oxidized into endocrocin by CPUR_05435 (By similarity).  Endocrocin could be then modified to clavorubin, possibly by CPUR_05423 and CPUR_05431 (PubMed:28955461).  Clavorubin is the principal anthraquinone metabolite produced by the cluster with a much higher yield compared to endocrocin (PubMed:28955461).
What are the official names of this protein?
Baeyer-Villiger oxidase CPUR_05427, Ergochrome gene cluster protein CPUR_05427.
What is the protein family that this protein belongs to?
Belongs to the questin oxidase family.
Protein: PY2CR_AGRFC
Sequence: MSDTTTLTIEALFQRVESIFLRAGLNAVQSGALARVITAGERDACKSHGIYRIEGALRTVKAAKVKPDAIPEVAEDDGTAIVKVNAMGGFANPAFELGLPALAERAKRLGLAALVINDCTHFSALWPEVEGLTSNGLAGLVMCPSYSTVAPTGGTKPLLGTNPFAFGWPRKDTSPYVFDFATSVAARGEIELHRRARKSLPEGWAVDADGNPTTDPEAALAGAMLPFGGHKGSAIGTMIELLAGIMIGDLTSPEVLDYLGTTTLAPFHGELIVAFSPEAFAKGRPGDPFQRAEVLFEAIIGQGARLPSGRRFAARAKSESEGITLTAAEMAGLDRLLEKGLDAVS
What is the function of this protein?
Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor.  Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow A. tumefaciens to grow on t3LHyp as a sole carbon source.
What are the official names of this protein?
Delta(1)-pyrroline-2-carboxylate reductase, Pyr2C reductase, Proline ketimine reductase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family.
Protein: MAO1_EDWI9
Sequence: MDLEHESKRPLYIPYAGPILLEFPLLNKGSAFSEEERNTFNLNGLLPEAIETIEEQVERAYRQFCDFHSATEQHIYLRNIQDTNETLFYRLLRSHLSEMMPIIYTPTVGEACEHFSYIYRRARGLFIAYPNRDRIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRITGDEYNAFVEEFIQAVKRRWPDVLLQFEDFAQKNAMPLLSRYRDRLCCFNDDIQGTAAVTLGSLIAASHAAGSRLRDQTITFLGAGSAGCGIAEQIIAQMIAEGLSDEEARTRIFMVDRFGLLTDRLPNLLDFQSRLVQKRQALAGWQTESEGISLLDVVRNAHPTVLIGVSGQPGLFSEAIVREMHSHCPRPIIMPLSNPTSRVEARPEDIINWTDGAALVASGSPFEPVLYQGERYPIAQCNNAYIFPGIGLGVLASGARRVTDGMLMAASRALADSSPLARDGHGSLLPDLKDIQQVSRDIAFQVAKAAQRQGVAVQTSDEALLQAIEHNFWLPIYRSYKRTSF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: AROE_CUPPJ
Sequence: MTSTESSQPADRYVVVGNPVAHSRSPFIHAAFARQTGEAVEYGRLEAPLDAFADTMRAFLAEGGYGFNVTVPFKLQAYDLADRLTPRAEAAGAVNTMWIEDGLIHGDNTDGIGLVRDIQDNLDTLLEDKRVLLLGAGGAAMGAMLPLIECRPSRIVVANRTASRASDMLEEFVEAADSFGVELWGGGLDALEQLSEDDVCDVVINASSSSLHGEVPPVPAFLLGDGVLAYDMMYGAEPTVFLQHAAQCGARTADGLGMLVEQAAEAFYIWRGVRPRTAPVLADLRAALQAERKG
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: ALDA_STAAB
Sequence: MAVNVRDYIAENYGLFINGEFVKGSSDETIEVTNPATGETLSHITRAKDKDVDHAVEVAQEAFESWSLTSKSERAQMLRDIGDKLMAQKDKIAMIETLNNGKPIRETTAIDIPFAARHFHYFASVIETEEGTVNDIDKDTMSIVRHEPIGVVGAVVAWNFPMLLAAWKIAPAIAAGNTIVIQPSSSTPLSLLEVAKIFQEVLPKGVVNILTGKGSESGNAIFNHDGVDKLSFTGSTDVGYQVAEAAAKHLVPATLELGGKSANIILDDANLDLAVEGIQLGILFNQGEVCSAGSRLLVHEKIYDQLVPRLQEAFSNIKVGDPQDEATQMGSQTGKDQLDKIQSYIDVAKESDAQILAGGHRLTENGLDKGFFFEPTLIAVPDNHHKLAQEEIFGPVLTVIKVKDDQEAIDIANDSKYGLAGGVFSQNITRALNIAKAVRTGRIWINTYNQVPEGAPFGGYKKSGIGRETYKGALSNYQQVKNIYIDTSNALKGLY
What are the official names of this protein?
Putative aldehyde dehydrogenase AldA.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: MURG_LACAC
Sequence: MRVIFTGGGTGGHIYPIMAIIERLKERGISKNDEILFVGTQKGLESKIVPAAGVNFETIQIQGFNRKHPLKNFETIKLFFQATKSARKILQEFKPDVVLGTGGYVSGAMVYEAAKMHIPTMIHESNSVVGLANKFLGHYVDKICYTFDDAAKEFPEKKKLVKTGNPRSQQVLGLHEDKVNLQKELGLNPQMPTVLVFGGSRGALAINRIMLKSLMELKKKPYQIIWATGTYYFDSVQKKLEGVDYGDNIKILPYIQNMPALLPEMTCVVSRSGATSIAEFTALGVPVILIPSPNVTHNHQMKNALDLQKAGAALVIPEDDLNPNNFVSSIDHILLDEKYANEMSEASKALGVPDASDQVIKVMEEISR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y1830_STAA1
Sequence: MAVNLYDYANQLEQALRESEEYKAIKEAFANVKANEESKKLFDEFRETQINFQQKQMQGEEIAEEDLQKAQEQAQAIEKDENISALMNAEQKMSQVFQEINQIIVKPLDEIYAD
What are the official names of this protein?
UPF0342 protein SAHV_1830.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.