PharMolix/UniProtQA huggingface dataset:
Protein: IL36B_HUMAN
Sequence: MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKLQGSQDNIGKDTCWKLVGIHTCINLDVRESCFMGTLDQWGIGVGRKKWKSSFQHHHLRKKDKDFSSMRTNIGMPGRM
What is the function of this protein?
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response.  Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP.  Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes.  Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases.  Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation.  In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
What are the official names of this protein?
Interleukin-36 beta, FIL1 eta, Interleukin-1 eta, IL-1 eta, Interleukin-1 family member 8, IL-1F8, Interleukin-1 homolog 2, IL-1H2.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: IQEC2_MOUSE
Sequence: MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREESQLHRGELHRDPLGARDSPGRESQYQNLRETQFHHRELRESQFHQASRDVGYPNRDGAYQNREAIYRDKEREASYQLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGQRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRNVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPTSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPPLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
What is the function of this protein?
Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins.
What are the official names of this protein?
IQ motif and SEC7 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the BRAG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y757_STRCO
Sequence: MRTSVVDVGSNTVRLMVADAEGGVPLPVHTAKWRLRLSEQVRPGDPVPEEAVERLVGAVADASRTADRWGASGPLAFATAVVRAAPNRREVLRTVQARTGVPLCTLPGEVEAELTFLAARRWMGWRSGPLALLDIGGGSLEVAFGRGRLPGFVASLPLGAARLTHEFLAGGRDPASPEQVKALRRRVRHQLRDAAARIRWEGPRTAVATSRTFQQLGRLCGAPPGRYGPFTERRMRCSDLGDAVGRLAALSAAERARLPGISAPRAAQSLAGAVVGHTAMKLTGLEAVALCPWAIREGVLLRHIEDGPAWWAEVVRRSDEAAPPAPVPLRLASASN
What are the official names of this protein?
Uncharacterized protein SCO0757.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family.
Protein: GLPK_CLOBJ
Sequence: MEKYIMSLDQGTTSSRCIIFNKKGEVVSVAQKEFTQIYPKAGWVEHDPLEIWGKQAGVAGEALNIARISPEQIAGIGITNQRETTVVWNKRTGMPIYNAIVWQCRRTAGYCDELREKGLDKTIKEKTGLMLDAYFSATKIKWILDNVEGARELAEKGDLLFGNIDTWLIWNMTKGKIHVTDYTNASRTMLFNIHELKWDEELLEILDIPKSMLPEVKPSSCVYGETDEILFGVSIPISGDAGDQQAALFGQTCFNAGMAKNTYGTGCFLLMNTGEKAVDSKNGLLTTIAVGIDGKVEYALEGSIFIGGAVIQWLRDELRMVKTAQETEKYATEVEDNNGVYLVPAFVGIGAPYWDSYARGTILGLTRGAKKEHIIRAALESMAYQTHDVLKAMEEDSGIELKALKVDGGACQNNFLMQFQSDILGVEVDRPEVVETTALGAAYLAGLAVGYWKDRNEISQNWAISRSFAPAMEDEKKEKLIKGWHKAVTKAMDWEDKE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: NU1C_POPTR
Sequence: MIIDTTTVQAINSFSRLKSLNEVYGIIWMLVPILTLVLGITIGILVIVWLEREISAGIQQRIGPEYAGPFGVLQALADGTKLLFKENLFPSRGDTRLFSIGPSIAVISTLLSYSVIPFGYHFVLADLNIGVFLWIAISSIAPIGLLMSGYGSNNKYSFLGGLRAAAQSISYEIPLTLCVLSISLLSNSSSTVDIVEAQSKYGLGGWNLWRQPIGFIIFFISSLAECERLPFDLPEAEEELVAGYQTEYSGIKFGLFYVASYLNLLVSSLFVAVLYLGGWNISIPYISVPEFFDFEINKVGRVFGTTMGILITLVKTYLFLFIPITTRWTLPRLRMDQLLNLGWKFLLPISLGNLLLTTSSQLFSL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ATPF_BACC7
Sequence: MPTLLLGAAIPFGTIAYTLFIFLLLLVMLRKFAWGPLMGIMKEREEHVTNEIDAAERSNAEAKKLVEEQREMLKQSRVEAQELIERAKKQAVDQKDAIVAAAKEEAESIKASAVQEIQREKEQAIAALQEQVASLSVQIASKVIEKELKEEDQVKLIRDYIKEVGEAR
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RLME_PSEAB
Sequence: MARSKTSQRWLKEHFDDPYVKMAQRDGYRSRASYKLLEIQEKDRILRPGMTVVDLGAAPGGWSQVTSRVIGDRGRLIASDILEMDSIPDVTFIQGDFTEDAVFARILEAIGDHPVDLVISDMAPNMSGVRAADQPRAMYLCELALDLAGRVLRPGGDFLIKIFQGEGFDQYHKQAREMFDKVQMRKPLSSRDRSREQYLLARGFRGE
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PER2_VITVI
Sequence: ISPLTGTNGEIR
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 2.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARF_CANAL
Sequence: MGLTISKLFASLLGRREMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRYYFQNTQGIIFVVDSNDRDRINEAREELQSMLNEDELKDAVLLVLANKQDLPNAMNAAEITEKMGLHSIRNRPWFIQATCATTGDGLYEGLEWLSNQVGK
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: BETB_YERPY
Sequence: MSRYGLQKLYINGAYTDSTSGDTFDAVNPANGECIAQLQAANAQDVDKAVAAAKQGQPVWAAMTAMERSRILRRAVDILRDRNDELAAIETADTGKPLSETRSVDIVTGADVLEYYAGLIPALEGQQIPLRGSAFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTSLTALKLAEIYTEAGLPAGVFNVLTGSGDQVGQMLTEHPGIAKVSFTGGIASGKKVMANAAGSTLKDVTMELGGKSPLIIFADVDLDKAADIAMMANFYSSGQVCTNGTRVFVPQALQAAFEQKIVERVKRIHIGDPSDERVNFGPLVSFQHRDSVMRYIDSGKREGATLLIGGCSLTEGALAHGAYVAPTVFTHCRDDMQIVREEIFGPVMSILSYQSEEEVIRRANDTEYGLAAGVVTQDLNRAHRVIHQLQAGICWINTWGESAPEMPVGGYKHSGVGRENGISTLEHYTQIKSIQVELGSFNSVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: SND1_DROME
Sequence: MATAANTATAAGAAKDAPPAPTKSLSGIVKQVLSGDTVVIRATKGAPPPEKQITFSHVLAPKLARRPGAGGDETKDEPWAWESREFLRKKLIGVEVTFTFDKPANSNREYGFVWIGKDKETGENVVESIVREGLVSVRREGRPTAEQQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLVDIYGGNPVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGVKLDADGKPDLSVKVPFADEARYYVETRLLQRDVEIRLESVNNSNFIGTILYPKGNIAESLLREGLAKCVDWSMAVMKTGTDKLRAAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFFSSIRPPRDQRAVVGTDGEEIVKAPPRGKNYRPLYEIPHMFDAREFLRKKLINKKVQCNLDYISPPRENFPEKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKGLKGLHAKKDNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGISCPRSSRPALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSGANLSVALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKVVAERKVNYENVIVTEITETLTFFAQSVESGSKLESLMSKLHADFQSNPPIAGSYTPKRGDLVAAQFTLDNQWYRAKVERVQGSNATVLYIDYGNKETLPTNRLAALPPAFSSEKPYATEYALALVALPTDNEDKEEALRAFSEDVLNHKVQLNVELKVTGSPNLATLRDPTTKVDFGKQLVAEGLVLAEQRGERKLKELVDQYKAAQEAARVAHLAIWKYGDITQDDAPEFR
What is the function of this protein?
Endonuclease which shows activity towards both DNA and RNA substrates (PubMed:14508492, PubMed:26808625).  Has a role in translation regulation throught its association with the with the RNA-induced silencing complex (RISC) (PubMed:14508492, PubMed:26808625).  Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline (PubMed:26808625).  Together with piwi, might be involved in transposon repression in the germline (PubMed:26808625).
What are the official names of this protein?
Staphylococcal nuclease domain-containing protein 1, Tudor staphylococcal nuclease.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Associates with ribosomes.
Protein: FLIT_SALAR
Sequence: MTSTVEFINRWQRIALLSQSLLELAQRGEWELLLQQEVSYLQSIETVMEKQTPPGITRSIQDMVAGYIKQTLDNEQRLKGLLQQRLDELSGLIGQSTRQKSLNNAYGRLSGMLLVPDAPGAS
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: LPA12_XENLA
Sequence: MTSLSEFVSEPIGMMSQTSAASESQCYYNETIAFFYNRSGKYLDTEWNAVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTVAIVMGAIPSVGWNCICDLEHCSNMAPLYSDSYLIFWTIFNLVTFVVMVVLYAHIFVYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCNILAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFKQILCCQRTENVNGPTEGSDRSASSLNHTILAGVHSNDHSVV
What is the function of this protein?
Receptor for lysophosphatidic acid (LPA)(PubMed:11278944).  Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents.  Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.  Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:11278944).  Signaling triggers an increase of cytoplasmic Ca(2+) levels.  Signaling leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate.  Signaling mediates activation of down-stream MAP kinases (By similarity).  Contributes to the regulation of cell shape (PubMed:11278944).  Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction.  Promotes the activation of Rho and the formation of actin stress fibers.  Promotes formation of lamellipodia at the leading edge of migrating cells via activation of Rac.  Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding.  Promotes cell proliferation in response to lysophosphatidic acid (By similarity).
What are the official names of this protein?
Lysophosphatidic acid receptor 1-B, LPA receptor 1-B, LPA-1-B, Lysophosphatidic acid receptor LPA1 homolog 2, xLPA1-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell surface. Cell membrane; Multi-pass membrane protein. Endosome. Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment.
Protein: HFQ_FRATO
Sequence: MSRISSLQDPFLNALRKEKVSVSVYLVNGIKLQGQVEAFDQFCIVLRNTVNQMVYKHAISTIVPAKSVRMVYSSFNPYHQNSNDEQDENVDDIHSDDLEIQENEGNIHE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: METE_LACLS
Sequence: MKKSIIAFPRIGSNRELKFALEKYFRKEISEAELQIVAKELRLESWKSQKEAGIDYPISNDFSFYDQTLDLSIALGVIPERYKKLKLNELDTLFALARGFQDEENDVKARPMKKWFNTNYHYIVPEISKETVIKANFSKLLNEYQEAKTAGFETRPTIIGPYTFLILADYLSGVTEDAILSDLIGAYTVLFDQLNNLGGEWLQIEEPALVLDQTEEEQQLFIKIYQELLKNKNKLKVLLQTYFGDLRDSYQEIIKLDFDGIGLDFVEGRESVKLVQKYGFPQDKLLFAGVVNGKNIWRNHYQKTLSLLKDLGNIDNIVINTSCSLQHVPVTTENEIKLSKEILNHFAFAKEKLVEVSEISEIYVKKNTSLLDKNIALFDKNRVQENIQLKQKITHLTDKDFIRTPSLVERRADQIKALRLPLLPTTTIGSFPQTPEVRKARLQYKRGELSKSDYEAFLEEKIKECLELQENIGLDVLVHGEFERNDMVEYFGEQLDGYIFTQKAWVQSYGTRCVKPPIVWGDITRPQAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKESTLQLALAVQEEVLDLEKAGIKIIQIDEAALREKLPLRRSDWYSEYLDWSIPAFRLVHSKVKAETQIHTHMCYSEFEDIIPSIDAMDADVISFEASRSQLSIIDALKAHHFQTLVGPGVYDIHSPRIPSSQEIKIQLEKILNKLPIEQVWVNPDCGLKTRGNKETIPSLTHLVEATKEVRKEKITYDK
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: DCEA_SHIFL
Sequence: MDQKLLTDFRSELLDSRFGAKAISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKQGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT
What is the function of this protein?
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction.  The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions.  The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity).
What are the official names of this protein?
Glutamate decarboxylase alpha, GAD-alpha.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: MUTS_FRATT
Sequence: MLTKRFYNLAIMQDISNHTPMIQQYLKIKSQYQDILLFYRMGDFYELFFDDAKKAAELLDITLTARGKSNGESIPMAGVPYHAAEAYIAKIVKKGLSIAICEQTGDPNTSKGPVERQVTRIITPATVSEEAFLDNNQDSILVSIFEKNNKYYLAYTSYTQGKIYLVKTLTSLNELKNTVLKLSPQEIITNSRELAQQNPFKKPIKALEEWYYSNFEAKKYINDSLDTNIANNILNLYKNDQLTTIGSILSYLTNILKDTPRHITDISYEQEQDTLNIDINSRINLELDNNSKSSLLSIIGKCKTSLGSRLLKRYFSNPTRNLNILATRHSIINSLGENQHFLKIQDVLSYISDIERIISRVALGTVKPKDLVALRDSLEQLPILKKLLSEKNTPEITNINNRIHQLDELVTLLDKAIIENPPTTIRDGGVIKEGFDKELDELKSIKDNSYDFLIKFEELQKQKTGISTLKVGYNSVHGYYIELSKQHADKIPTEYVRRQTLKASERYITEELKNFEDKVLSSKEKALAREKLIYDTLLKKVIEYYKQIQETAASIAEIDVLANFAERAIKLKLSQPKFNNLAKLELKEVRHLAIEHNIDEPFIPNDTLLSKDTNTLQIITGPNMGGKSTYMRQVAQLIFLAYIGSFVPASYADICDIDTIYTRIGASDDISSGRSTFMVEMTETAYILNNASAKSLVIMDEIGRGTSTFDGLALAKACAEKFAQIGAFTLFATHYFELTELAKQYPNVCNIHFEAKEYKDNIYFMHKAVTGAAKKSYGIQVAKLAGISQDVLESAKQNLYNLEKKQQLTESTQVQAQFQLEPTTQNPLQQKLDAIDINTITPLEALNILFELKKTLI
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: AROE_LACLM
Sequence: MKIDGYTRMAAVVANPIKHSLSPFIHNLAFDLTDENGVYLAWEVESKKLAAIVENVRNLDMYGLNISMPYKGEIIKFMDELSPAAELIGAVNTVVNHSGKLIGHNTDGIGFFNSLKKYDFKIENKQILVLGGGGAAIALIAQAALSGAKKIVVAARKSASYDPLNEKLAKLSAKTGVEILLTDLSGADRLQKELNQTDLLVNATSVGMDGASFPLEKSLLLPDKLLVVDAIYKVRETPFLHWAKEQGAQTENGLGMLIGQAAESFYLWTGKEMPVDKITLEMEREV
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: RL21_FRASN
Sequence: MYAVVASGGKQHRVAVGDVVDVELLSGEPGAAVNLPAVLLVDGESVTHDADALASVEVTAEVVGVVKGPKIRIHKFKNKTGYHKRQGHRQKYTRLKVTGIETGKA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: DCD_HELPY
Sequence: MGLKADSWIKKMSLEHGMISPFCEKQVGKNVISYGLSSYGYDIRVGSEFMLFDNKNALIDPKNFDPNNATKIDASKEGYFILPANAFALAHTIEYFKMPKDTLAICLGKSTYARCGIIVNVTPFEPEFEGYITIEISNTTNLPAKVYANEGIAQVVFLQGDEMCEQSYKDRGGKYQGQVGITLPKILK
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: NTE1_EMENI
Sequence: MADSGASVPSPDLPDLDSLHASLSLPDIPSVAATSLSTSLPAISAKVSGFPSFSSHLPPPPLLSPPTPTTMVGWIGWVFSLVFQTIPSVLYWVITFSTITLPTWLFTLFSMSLTFTMNFTTLLLIVLGLVSTVSWFIRYRFLNMYSRLPPEPQRKEPQLDLFPDVQEGDSKPGLANYLDEFLSAIKVFGYLERPVFHELTRTMQTRKLIAGETLQLEEEKGFCLVVDGLVQIFVKSMRSGKHGLNGEVIEGSSDEDDQARDGKQGYQLLTEVKNGASMSSLFSILSLFTEDIRLRASEGSSSSMSSVQPSPARTTPAPFLDSPGEMLNGSPMVLPRDSEVDSSAINGEAEPLPPVPPLHLGESRASSYHPNGQSTASERVRGNRRKSVHPDIVARAMVDTTIAIIPASAFRRLTRLYPRATAHIVQVILTRLQRVTFATAHSYLGLTNEVLGIEKQMTKFTTYDLPNDIRGAALDRLKDKFLKEKDRLGSEEVTRGIALHNPYAGRRRRSMSFVRKEAALKAKMPLPKRPNSLINPERPFHGYDTAGVSPGDLLSTIQLSRFGPRHDQFATTPRLHSPLTEKERSPLRRSSLQRKDSVDEDALFRESILDCIMKGIGLTPSSHNALRKGSHSGELSPKLVSYDSRRQKAVFSNNAFGFIDAYEGSGDGDTESMMSMSVTSAGGTSPIVYLREDLLNDIEIVYFPKGAVLVEQGERHPGLYYVIDGFLDVGVQVNEKGDDLVGASRPGHAQPDEELFPTLKRTQTATSRGATAAAPINESKRKKPSRKSLYMIKPGGMQGYVGAMASYRSYTDVVAKTDVYVGFLPRASLERLAERYPIALLTLAKRLTGLLPRLLLHIDFALEWVQVNAGQVIYHQGDESDAIYITLNGRLRSVHEGKGGKMTVVGEHGQGESVGELEVMTESTRPATLHAIRDTELAKFPRSLFNSLAQEHTGITIQVSKLIAQRMRDLVENPMTEQGEPGNTGSVKTATSTLNLRTVGILPITTGVPVVEFGNRLLSALQQIGVTDGVTSLNQAAILNHLGRHAFSRMGKLKLSQYLADLEEKYGMVLYIADTNVNSPWTQTCISQADCILLVGLAESSPNVGEYERFLLGMKTTARKELVLLHADRYCPPGLTRKWLKNRVWINGGHHHIQMAFRLTAEPSHPQTKRLGTVLKQRVQILQAEIQKYTSRRIRQTPIYSAQTPFKGDFHRLARRLCGRAVGLVLGGGGARGIAHVGVIKALEEAGIPVDIVGGTSIGAFIGGLYARDADVVPMYGRAKKFAGRMGSIWRFALDLTYPSVSYTTGHEFNRGIFKTFGDSQIEDFWLEFYCNTTNISRSRAEYHSSGYVWRYVRASMSLAGLLPPICDEGSMLLDGGYIDNLTVAHMKTLGADVIFAIDVGSIDDNTPQGYGDSLSGMWSVINRWNPFSSIPNPPTLSEIQARLAYVSSIDNLERAKNIPGCLYMRPPIDRYGTLEFGNFDEIYQVGYAYGKEYLQKLKSQGSLPLPEENEEKKKLQRTLAPRRASI
What is the function of this protein?
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho).  Plays an important role in membrane lipid homeostasis.  Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
What are the official names of this protein?
Lysophospholipase nte1, Intracellular phospholipase B, Neuropathy target esterase homolog.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ZC21A_MOUSE
Sequence: MDGLEENGSVVQVGDLLPCKICGRTFFPLALKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYDPDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDSKGKPASRPQYKPSPLKKSNPPGIPSSGSSRLPQPSTTSKTIVGVPTGKASSVNSPLGNKPQTLSPSHRAIAAPQAGANTKARNTTPPSLARNSVAGVLTNKRKTLTENYAARPDGDYTSSVNGGNSKGIEGNSSGHLPKFCHECGTKYPVEWAKFCCECGIRRMIL
What are the official names of this protein?
Zinc finger C2HC domain-containing protein 1A.
What is the protein family that this protein belongs to?
Belongs to the ZC2HC1 family.