PharMolix/UniProtQA huggingface dataset:
Protein: ACL6A_MACFA
Sequence: MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDKGKQGGPTYYIATNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRKEKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAERLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSFTDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).  Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.  Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix.  Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors.  During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.  The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.  As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).  The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.  The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).  Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.  This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.  NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.  Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity).
What are the official names of this protein?
Actin-like protein 6A, BRG1-associated factor 53A, BAF53A.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CWP02_ARATH
Sequence: EDRTY
What are the official names of this protein?
65 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: FEN_THESM
Sequence: MGVPIGELLPKKELELENLNGRKVAIDAFNAIYQFLSTIRQKDGTPLMDSKGRITSHLSGLFYRTINLMEAGIKPAYVFDGKPPEFKKKELEKRAETREEALEKWEIALARGELEEAKKYAQRASKINEILIEDAKKLLELMGIPWVQAPSEGEAQAAYMASKGDVWASASQDYDSLLFGTPKLVRNLTITGKRKLPGKDVYIEVKPELILLEDVLKELKLTREKLIELAILVGTDYNPGGIKGLGPKKALEIVKYSKDPLSKYQKTSEVDLYAIKEFFLNPPTTNDYKLEWKLPDEESIIKFLCDEHDFSEERVKNGLERLKKVTKTGKQFTLDTWFKK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: ACE2_RAT
Sequence: MSSSCWLLLSLVAVATAQSLIEEKAESFLNKFNQEAEDLSYQSSLASWNYNTNITEENAQKMNEAAAKWSAFYEEQSKIAQNFSLQEIQNATIKRQLKALQQSGSSALSPDKNKQLNTILNTMSTIYSTGKVCNSMNPQECFLLEPGLDEIMATSTDYNRRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYEDYGDYWRGDYEAEGVEGYNYNRNQLIEDVENTFKEIKPLYEQLHAYVRTKLMEVYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTTPFLQKPNIDVTDAMVNQSWDAERIFKEAEKFFVSVGLPQMTPGFWTNSMLTEPGDDRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYAKQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSNFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFQDKIPREQWTKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKHDGPLHKCDISNSTEAGQKLLNMLSLGNSGPWTLALENVVGSRNMDVKPLLNYFQPLFVWLKEQNRNSTVGWSTDWSPYADQSIKVRISLKSALGKNAYEWTDNEMYLFRSSVAYAMREYFSREKNQTVPFGEADVWVSDLKPRVSFNFFVTSPKNVSDIIPRSEVEEAIRMSRGRINDIFGLNDNSLEFLGIYPTLKPPYEPPVTIWLIIFGVVMGTVVVGIVILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF
What is the function of this protein?
Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis.  Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II.  Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin.  Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A.  Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity.
What are the official names of this protein?
Angiotensin-converting enzyme 2, ACE-related carboxypeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M2 family.
What are the subcellular locations of this protein?
[Processed angiotensin-converting enzyme 2]: Secreted. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, cilium. Apical cell membrane. Note=Detected in both cell membrane and cytoplasm in neurons.
Protein: Y020_HIS1I
Sequence: MVSSKWNMITELFLGAANSYAQMRGKITHYEIQHDGTIQHEFIDPSNTEEKAWDLEDNPEQQISVKGYANSCTLTVKDDSNEVELVPSGRYKQYMENQILSQTMQTGSMDSQKMMYLSIANLATLLLFGIIGLSIIT
What are the official names of this protein?
Uncharacterized protein ORF20.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: KITH_MYCPN
Sequence: MSFSQVFHQSPRGWIEVICGPMFSGKTEELLRKIKRWKLAKIPVIIFKPKIDTRQQHLVKSRNGHSDEAIEINSPLEIYDYLTKDRFDVVAIDEAQFFSSEIVEVVKSLNDLGINVIVSGLDTDFRAEPFGSIPQLLAIADKICKLDAVCNVCGQLAQRTQRIVSKSNETVLIGDIEAYEPRCKLHQPSAG
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKSG2_CANSA
Sequence: MNHLRAEGPASVLAIGTANPENILIQDEFPDYYFRVTKSEHMTQLKEKFRKICDKSMIRKRNCFLNEEHLKQNPRLVEHEMQTLDARQDMLVVEVPKLGKDACAKAIKEWGQPKSKITHLIFTSASTTDMPGADYHCAKLLGLSPSVKRVMMYQLGCYGGGTVLRIAKDIAENNKGARVLAVCCDMTACLFRGPSDSNLELLVGQAIFGDGAAAVIVGAEPDESVGERPIFELVSTGQTFLPNSEGTIGGHIREAGLMFDLHKDVPMLISNNIEKCLIEAFTPIGISDWNSIFWITHPGGKAILDKVEEKLHLKSDKFVDSRHVLSEHGNMSSSTVLFVMDELRKRSLEEGKSTTGDGFEWGVLFGFGPGLTVERVVLRSVPINY
What is the function of this protein?
Polyketide synthase responsible for the biosynthesis of secondary metabolites.
What are the official names of this protein?
Polyketide synthase 2.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_CORDI
Sequence: MRPELSQYTHVSAGKVREIYEVDDERLLMVVSDRISAYDHILEPEIPDKGRVLTAMSMYFFHNIDFPNHLAGPIDDPAIPEEVLGRAMVCKKLKMLPFECVARGYLTGSGLKEYQETGTVCGVELPEGLVEASKLPEPIFTPATKAELGDHDENVSFDVVVEKLGEARANELRDATLRIYSEAAALAEERGIILADTKFEFGLDEDGRLVLADEVLTPDSSRYWPADGYEEGKVQPSFDKQYVRNWLTGPKSGWSTDDVTPPPSLPGSVVEATRERYVEAFERITGKKFCEWIGCCV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: MIAB_MARN8
Sequence: MAKKLYIKTHGCQMNEYDSARMADLLKTGEAVEVTDNADDADILLLNTCSIREKAQEKVFHQLGRWKSLKTKKPDLIIGVGGCVASQEGQAIIDRAPYVDMVFGPQTLHRLPDMITEVRTKGNGVGVVDVSFPEIEKFDNLPEPGADGPSAFVSIMEGCSKYCTFCVVPYTRGEEVSRPVDDVIAEVAHLAAQGVREVNLLGQNVNAYRGETHDGDQMDLAELIEVIATIDGIDRIRYTTSHPVEFSDALIEVYERVPELVSHLHLPVQSGSDRILAAMKRGHTALEYKSKLRRLRKIRPDISFSSDFIIGFPGETDKDFEDTMKLINDIGFDMSFSFIYSARPGTPASDLPDDTPMEVKKQRLSILQDRLNQNVMDISRKMVGSTQRILVTGLSKKDPGEYAGRTENNRIVNFRHENPEVVGHFIDVEIVEAYPNSLRGVPVSSELF
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR4D5_HUMAN
Sequence: MNPANHSQVAGFVLLGLSQVWELRFVFFTVFSAVYFMTVVGNLLIVVIVTSDPHLHTTMYFLLGNLSFLDFCYSSITAPRMLVDLLSGNPTISFGGCLTQLFFFHFIGGIKIFLLTVMAYDRYIAISQPLHYTLIMNQTVCALLMAASWVGGFIHSIVQIALTIQLPFCGPDKLDNFYCDVPQLIKLACTDTFVLELLMVSNNGLVTLMCFLVLLGSYTALLVMLRSHSREGRSKALSTCASHIAVVTLIFVPCIYVYTRPFRTFPMDKAVSVLYTIVTPMLNPAIYTLRNKEVIMAMKKLWRRKKDPIGPLEHRPLH
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 4D5, Olfactory receptor OR11-276.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AMJ_BACSU
Sequence: MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSLFNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPSFVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKRLFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSVLADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF
What is the function of this protein?
Involved in peptidoglycan biosynthesis.  Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.  May serve as a defense mechanism against naturally occurring MurJ antagonists.
What are the official names of this protein?
Lipid II flippase Amj.
What is the protein family that this protein belongs to?
Belongs to the Amj family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YGI4_SCHPO
Sequence: MDSNTNENNSHASSNERQSSEGHDDYLNRNPNSEATEGEEGTHPTTGTQPVAFSIGTMFIITPQANFEGGENDPFANPFQPPVKRAVKEAWDSFEPLSNDQLMDLTCPICYDDMNENDEKQATKMPCGHIFGKNCLQKWLENHCTCPLCRKEVPHETVGSAHPPILFIIPHSHTLRGNQGNTAVSQENASNGVHSDFHPSEELNNANTDGRTGVDEPARQLHRIAFNRIRFILAPNRSATNTPVENTHPENPDSNTSTPTTRSEPLAGEGASIDAENASSRQETTPSDSRPSTLTSLFNAFFSSMPDRPSSNEPMTSNLTSNSGSMTNSTSTDLPTSNLPSQNAPARPVEPSPSIQPPNLLNLPTASPESTSWLPGSQTNIPANTNRSERPFTQLMTFHGLPSLADLPAVLESMFRPSGNNNLLNLNGIFHPDHNAQTENGQTLPENTDDTNSNATSAVPNLQNLNQQNAVTMGTNTPNNGSSPAVHPVIHIYLSRPPLQPAVSEQETPSEAVSREGTRSTDATMEDSSRPPSNGSFQGPGITHLSEMGQRILQRFQEEMENRMNQTRSESSTPAQQSAAGSSINVDTAGRQPSDEINIPGEYENSSEVAGSRNQTPTHSSIAVDTLSNVAVDQPAISTPSDVVGSDAGDTSKVSSGTSTPRMAAPIARRSNRHHPYSRPSSTRPQCQLEDQGICDPNDRFVHFECGHSVHERCQQSTSNSENQMDEEIGECPKCRNEEHK
What are the official names of this protein?
Uncharacterized RING finger protein C2A9.04c.
What are the subcellular locations of this protein?
Nucleus.
Protein: OMCA_CHLP6
Sequence: MKKAVLLATVFCGVVGLTSCCRIVDCCFEDPCAPKPCNPCGNKKDKGCSPCGVYTPSCSKPCGSECNPGVQGPQAKGCTSLDGRCKQ
What is the function of this protein?
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the large cysteine-rich periplasmic protein and the major outer membrane porin.  It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan.
What are the official names of this protein?
Small cysteine-rich outer membrane protein omcA, Small-CRP, 9 kDa cysteine-rich lipoprotein, 9KD-CRP.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Note=The protein moiety probably penetrates into the periplasm.
Protein: Y1786_ALIFM
Sequence: MTEQFWQQKKLEEMTEQEWESLCDGCGKCCLHKLMDEDTDEVYYTNVACSWLNSKTCACKDYPKRFTSGEECLKLSRENIAEFNWLPLTCAYRLLAEDKPLPEWHPLITGSKSAMHAAGESVRNKVVYAIDVKNWEDHITNHPHRS
What are the official names of this protein?
UPF0260 protein VFMJ11_1786.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: RLPA_SALTY
Sequence: MRKQLPVICVAAGIVLLAACTNDGGQQQTTVAPQPAVCNGPTVEISGAEPRYEPLNPTANQDYQRDGKSYKIVQDPSRFSQAGLAAIYDAEPGSNLTASGEMFDPMQLTAAHPTLPIPSYARITNLANGRMIVVRINDRGPYGTDRVISLSRAAADRLNTSNNTKVRIDPIIVAPDGSLSGPGMACTTVAKQTYALPPRPDLSGGMGSASSAPAQPQGDVLPVSNSTLKSDDTTGAPVSSSGFLGAPTTLAPGVLESNEPTPAPQPAPVSAPVAAPATAPATATPVSAPAAAAPVSAPVSAPAAAASGRFVVQVGAVSDQTRAQQYQQRLSQQFSVPGRVIQNGAVWRIQLGPFASKAEASALQQRLQTEAQLQSFIASAQ
What is the function of this protein?
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
What are the official names of this protein?
Endolytic peptidoglycan transglycosylase RlpA, Rare lipoprotein A.
What is the protein family that this protein belongs to?
Belongs to the RlpA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RRF_HYPNA
Sequence: MSYSKQDIERRMEGALASLASEFAGLRTGRASVNLLDSIQVPAYGGVTPLSQVASVTVSDTRMLSVNVWDKTVVGAADRAIRDSGLGLNPVMDGQTLRIPIPPLNEERRVELTKIAGKYAEAARVAVRNVRRDGMDDLKKAEKDGEISEDRHRALTEEVQKLTDAFVKRVDEALKAKEAEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT6_CYRSC
Sequence: MGTARFLSAVLLLSVLLMVTFPALLSAEYHDGRVDICSLPSDSGDCLRFFEMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Dual-function toxin that inhibits both serine proteases and voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hs1a, U15-TRTX-Hs1a, Huwentoxin HW11c10, Kunitz-type serine protease inhibitor HWTX-XI-IS6.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 03 (sub-Kunitz) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYP_CITBB
Sequence: MRYSQYFIPTVKETPSDAEVISHKLMLRAGMIRKLAAGIYNYLPFGLRSIRKVEAIVREEMNRAGAIELLMPAVQPAELWKESGRWEFYGKELLRFNDRKDAEFCMGPTHEEVITDLIRKEVRSYRQLPINLYQIQGKFRDEIRPRFGLMRGREFIMKDAYSFDVNEAGADVSYEKMYKAYRRIFERCGLKFRAVEADTGTIGGSYSHEFMVLADSGEDAIVSCSACEYAANMEKAETRKGEGIEHADPRPMEHVSTPGQKSIEDVATFLGVQNTQVVKTLVLVADGEPVVALIRGDYDLNEIKLKNHLGCAELEMAEDDVVVKVTGAPTGYAGPVGLAAKVKVVADLSLEGMHNFVTGANAADTHLKNVNIGRDFSVSGFVDIRNVVIGDACPRCDSGKLEIWRGIEVGHVFKLGTKYSKALKATFLDADGKEQIIFMGCYGIGVGRTVAACIEQNHDENGIIFPIPIAPFQCIISSLSAKEDEVKAASESIYQELLEAGIEVLLDDRDERPGFKFKDADLIGIPLRIVVGAKALAEGKVELKERRSGEVEVLPIAEAIAKVKAAVKEALQV
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_SHEHH
Sequence: MIGRIRGLLIEKQAPEVLVDVSGVGYEIQMPLTSFYELPELGQEAVIYTHFVVREDAQLLYGFISKQERSLFRLLIKANGVGPKLGLTILSGMTAREFVACVERDDIATLVKLPGVGKKTAERLLVEMRDKLKSLMEASVGSEREFMLQSNYTAPEAVNTAEEDAIAALLSLGYKPAQASKAVSSVYTDGMSSETLIKSALKSML
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: VIRH_HYPVG
Sequence: MVCAWQLWLSPRPKRSVIASGSHIYSNDDAALFEFLKEDDGRWVVRETHYINNPLVKNGLSGPPLHIHWKQAEYFKVEQGVIGIHKNGKQLRVTKDDGVIEVPAGTRHKFWSHPSNQEDLVFKVWAEPQGLDHSFDEKFIRNLIGYQRDCKMANMAPSVFQLMLICYDCATLATPPFWVPLWLLTSIQYVLAYWIGGHLLGYKPSYSEYYREPGDKKTM
What is the function of this protein?
Probable oxidoreductase; part of the gene cluster that mediates the biosynthesis of virensols and trichoxide, fungal natural products that contain or are derived from a salicylaldehyde core (PubMed:31790246).  The pathway begins with the synthesis of the reduced chain in virensol C by the highly reducing polyketide synthase virA via condensation of one acetate and 8 malonate units (PubMed:31790246).  VirA has interesting programming rules since the first 2 ketides are fully reduced, the 3 following ketides undergo beta-dehydration, and the last 3 ketides are only reduced to beta-hydroxys to yield the trihydroxy portion (PubMed:31790246).  The production of aldehyde virensol C by virA alone is surprising, since virA does not contain a reductase (R) domain that is typically associated with reductive product release in HRPKS (PubMed:31790246).  The cupin-domain enzyme virC is involved in enhancing virA product turnover (PubMed:31790246).  The short-chain dehydrogenase virB then oxidizes the C-7 alcohol of virensol C to a ketone, yielding virensol D (PubMed:31790246).  Virensol D is further transformed to salicylaldehyde 5-deoxyaurocitrin by the short-chain dehydrogenase virD (PubMed:31790246).  VirD catalyzes the dehydrogenation of C-3 to form the beta-ketone aldehyde, which is followed by the generation of the nucleophilic C-2 that is required for the intramolecular aldol condensation between C-2 and C-7, itself followed by dehydration and aromatization which leads to salicylaldehyde 5-deoxyaurocitrin (PubMed:31790246).  While the dehydrogenation of virensol D is definitely catalyzed by virD, the aldol condensation and dehydration may be uncatalyzed or assisted by virD (PubMed:31790246).  The short chain dehydrogenase virG then converts salicylaldehyde 5-deoxyaurocitrin into virensol B which is further hydroxylated by the cytochrome P450 monooxygenase virE to yield the hydroquinone virensol A (PubMed:31790246).  VirI then may oxidize virensol A to form the quinone, while virH performs the epoxidation (PubMed:31790246).  Finally, the two remaining short-chain dehydrogenases, virK and virL, are probably responsible for reducing the ketones to the corresponding alcohols to furnish the epoxycyclohexanol structure in trichoxide (PubMed:31790246).
What are the official names of this protein?
Probable oxidoreductase virH, Trichoxide biosynthesis protein H, Virensol biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the oxidoreductase OpS7 family.
Protein: RL10_COXBN
Sequence: MALNLEQKKAMVAEITDIANQAVSAVAADYRGLTVSEMSDLRKSAREARVHMRVYRNTLARRAFKETTYACLEEVLTGPIVLFFSQEEPGAAARLIEKFIKEHERLEVKGLALGGELLPAEKLKAVARLPSREEALSQLAAVLLAPVTKLVRTLNEPIAQVARVMAAVRDQKAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: NS1_I96A3
Sequence: MDSHTVSSFQVDCFLWHVRKQVADQDLGDAPFLDRLRRDQKSLKGRGSTLGLNIETATCVGKQIVERILKEESDEAFKMTMASALASRYLTDMTIEEMSRDWFMLMPKQKVAGPLCVRMDQAIMDKNIILKANFSVIFDRLETLTLLRAFTEEGAIVGEISPLPSLPGHTNEDVKNAIGVLIGGLEWNDNTVRVSETLQRFAWRSSNENGGPPFTPTQKRKMAGTIRSEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: 4HYPE_BURPB
Sequence: MRISTLDRRDMKHIHIIDSHTGGEPTRVVVSGFPALGGGTMAERLAVLAREHDRYRAACILEPRGSDVLVGALLCEPVSAGAAAGVIFFNNAGYLGMCGHGTIGLVRTLHHMGRIGPGVHRIETPVGDVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGHGAVTGDVAWGGNWFFLVSDHGQRVAGENVAALAAYASAVRAALERAGVTGRDGAPIDHIELFADDPEYDSRSFVLCPGHAYDRSPCGTGTSAKLACLAADGKLAAGVTWRQASVIGSVFSASYAAAEGGVVPTIRGSAHLSAEATLVIEDDDPFGWGIAS
What is the function of this protein?
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp).  Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate.
What are the official names of this protein?
4-hydroxyproline 2-epimerase, 4Hyp 2-epimerase, 4HypE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.