PharMolix/UniProtQA huggingface dataset:
Protein: E41LB_MOUSE
Sequence: MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSVLPAAPGGSVFPAGGGPLLTGGAAVHISASGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVTHWLDHAKPIKKQMKVGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKEYRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPSNSKSARSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSKANPEVHNYQPQYHPDVHPSQPRWRPHSPNVSNHSICKQNKPCFQDDRPHWKTSASGDGSHFDYVQDQNQRNLGGAYSVTYRDKLMTAL
What is the function of this protein?
Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (PubMed:22006950).  Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).  Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (By similarity).  May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (By similarity).
What are the official names of this protein?
Band 4.1-like protein 4B, Erythrocyte membrane protein band 4.1-like 4B, Protein EHM2.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, tight junction. Note=Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner.
Protein: RS28_METVS
Sequence: MADDMVYQEAVAAEVIQVSGRTGVTGEIFQVRCKILGGKDTGRILTRNVKGPVKVGDLIMLRETEREAKQLGKRRK
What are the official names of this protein?
30S ribosomal protein S28e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS28 family.
Protein: TORD_SALSV
Sequence: MNKQPALAQEQYACVYAWLALLFFREVDDEGLIQLQSAEIADWLALLKRQPALAASVALLEQKIAALSLRQDAQLELAADFCGLFLMTDKKSALPYASQYPQQEPGMIKHLLLEAGMEVNDDFKEPTDHLAIYLELLSHLHFSLGESFQQRRMNKLRQKTLSSLLEWLPEFTNNCFKHDSYGFYAALSQLLLAIVRFDDGKEDLSIVAAE
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCRC_ECOLI
Sequence: MEQPVIPVRNIYYMLTYAWGYLQEIKQANLEAIPGNNLLDILGYVLNKGVLQLSRRGLELDYNPNTEIIPGIKGRIEFAKTIRGFHLNHGKTVSTFDMLNEDTLANRIIKSTLAILIKHEKLNSTIRDEARSLYRKLPGISTLHLTPQHFSYLNGGKNTRYYKFVISVCKFIVNNSIPGQNKGHYRFYDFERNEKEMSLLYQKFLYEFCRRELTSANTTRSYLKWDASSISDQSLNLLPRMETDITIRSSEKILIVDAKYYKSIFSRRMGTEKFHSQNLYQLMNYLWSLKPENGENIGGLLIYPHVDTAVKHRYKINGFDIGLCTVNLGQEWPCIHQELLDIFDEYLK
What is the function of this protein?
Modifies the specificity of McrB restriction by expanding the range of modified sequences restricted.  Does not bind to DNA.
What are the official names of this protein?
Type IV methyl-directed restriction enzyme EcoKMcrBC, EcoKMcrBC, Protein McrC.
Protein: FLIE_AGRRK
Sequence: MIDAIKNVSSLSATRGLGSIATDLSSAASNAIASTPETAIGSSAVGSFASVMSDVAKNTVSTLKEAENASFAGIKGTMSTREVVDKVMQADQTLQTAIALRDKMVSAFLDITKMQI
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: TMA7B_HUMAN
Sequence: MSSHEGGKKKALKQPKKQAKEMDEEEKAFKQKQKEEQKKLEVLKAKVVGKGPLATGGIKKSGKK
What are the official names of this protein?
Translation machinery-associated protein 7B.
What is the protein family that this protein belongs to?
Belongs to the TMA7 family.
Protein: MNTH_KLEP7
Sequence: MTSSRVENSSSRAARKVKLALMGPAFVAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQVLSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLVLGVSLLQGAVLTGVATFLILMLQRRGQKPLEKVIGGLLLFVAVAYVVELIFSQPALAPLTKGLVIPTLPNGEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGTRKERYNATRWDVAIAMTIAGFVNLAMMATAAAAFHFNGHTGVADLDQAYMTLEPLLSHAAATIFGLSLIAAGLSSTVVGTLAGQVVMQGFIRFHIPLWFRRAITMLPSFVVILLGLDPTRILVMSQVLLSFGIALALVPLLIFTSNAKLMGDLVNTRWVRGIGWAIVAIVVSLNGWLIVGSLLGVD
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPD_LISIN
Sequence: MSKDLEVAGRYANALFQVAQDKDLVDVFSEELTELKAALNANKDFVKLLENPTFTTEQKKNLASAVFEKINPTLRDFIYLLIDRSREDYLSVIADVYQKRVNDLRGVADADVYSVVPLSEQELTALSRVFAAKMNKTKLNIQNHIDKSLLGGVKVVIGTRIYDDSLKTKLKDMERQIKA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RBSA_CHESB
Sequence: MTDFVQLIGIEKHFGGIAALKSVDFTVKSGEVHALIGENGAGKSTLMGVLSGNVIPTAGTISVEGCVRRFSTPGDAIAAGIAMIHQELVLAPDLTVAENIFMNRMPRLIDWAKLRRDAAQILDRLGFEIDPGATIGDLPLAQRQIVEIAKALSLNARLIIFDEPTAVLGPSDARRLLNLIRSLRSEGVAIVYISHRLDEVADIADRVTVLNDGSLIATRAAKDVTIEEMVRLMVGRPISALFGEKRTSPFGAEIFRVESLTAGPLVQDLSFGVRAGEIVGLGGLIGSGRTETARAIFGADKRESGRIFIDGSQVKIRDPRDAVKAGIGLVPEDRRGQGVVIDASIRINTTMTSLRRFSPAGIIKRTFERRFVGEKIAALKVKSAGIDAPVQSLSGGNQQKVVIGKWVDVASKVIILDEPTRGVDVGAKSEIYAIIRRLADEGRAVLLISSDHQELFGLCDRVLVMGRGRIRSELLPGEFDEERLLSASLAIEPIQTTVRTDQNPAG
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PLSX_AGRRK
Sequence: MIRISLDLMGGDFGPEVVIPGAAKALERHPDITFIMYGMKDRCEPILGKYAKLREKSVFHECDVSISMDEKPSQALRRGRYVSSMWRSIEAVKLGEADVVVSAGNTGALMAMAKFCLRTMANIERPAIAAIWPTLRGESIVLDVGATIGADSQQLLDFALMGGAMARALFEIERPTIGLLNVGVEEIKGQEDVKEAGRLIREANLESLEYSGFVEGDDIGKGTVDVVVTEGFSGNIALKAAEGTAKQIGAYLRSAMTRTLLARIGYLFAKGAFDLLREKLDPSKVNGGVFLGLNGIVIKSHGGASAEAFAAAIDVGYDMAKNGLTQKIENDLKRYHAKRQPPIGPEAA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: GAPT_HUMAN
Sequence: MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKTFLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY
What is the function of this protein?
Negatively regulates B-cell proliferation following stimulation through the B-cell receptor.  May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity).
What are the official names of this protein?
Protein GAPT, Growth factor receptor-bound protein 2-binding adapter protein, transmembrane.
What is the protein family that this protein belongs to?
Belongs to the GAPT family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: LSPA_KLEAK
Sequence: MSKSICSTGLRWLWVVVAVLIIDLGSKFLILQNFALGETVSLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIAVGICVVLAVLMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATFNLADSAICIGAALIVLEGFLPSSDKKTS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ITFG2_PONAB
Sequence: MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKVSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLLVAVSAEGWFHLFDLTPAKVLDASGHHETLIGEEQRPVFKQHIPANTKVMLISDIDGDGCRELVVGYTDRVVRAFRWEELGEGPEHLTGQLVSLKKWMLEGQVDSLSVTLGPLGLPELMVSQPGCAYAILLCTWKKDTGSPPASEGPMDGSRETPAARDVVLHQTSGRIHNKNVSTHLTGNIKQGHGTESSGSGLFALCTLDGTLKLMEEMEEADKLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLVKLLETKPEYHSLLQELGVDPDDLPVTRALLHQTLYHPD
What is the function of this protein?
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway.  Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases.  Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids.  In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated.  The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
What are the official names of this protein?
KICSTOR complex protein ITFG2, Integrin-alpha FG-GAP repeat-containing protein 2.
What are the subcellular locations of this protein?
Lysosome membrane. Note=Localization to lysosomes is amino acid-independent.
Protein: ZN559_HUMAN
Sequence: MVAGWLTNYSQDSVTFEDVAVDFTQEEWTLLDQTQRNLYRDVMLENYKNLVAVDWESHINTKWSAPQQNFLQGKTSSVVEMERNHFGEELFDFNQCEKALSEHSCLKTHRRTYFRKKTCECNQCEKAFRKPSIFTLHKKTDIGEELPNCNQCETAFSQHLHLVCKKTSQNLHLVCKKTHTQEKPYKCSDCEKGLPSSSHLRECVRIYGGERPYTHKEYVETFSHSTALFVHMQTQDGEKFYECKACGKPFTESSYLTQHLRTHSRVLPIEHKKFGKAFAFSPDLAKHIRLRTRGKHYVCNECGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGKAFANSSHLTVHMRTHTGEKPYQCKECGKAFINSSSFKSHMQTHPGVKPYDCQQCGKAFIRSSFLIRHLRSHSAERPFECEECGKAFRYSSHLSQHKRIHTGERPYKCQKCGQAFSISSGLTVHMRTHTGERPFECQECGKAFTRSTYLIRHLRSHSVEKPYKECGQTFSNSSCLTECV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 559.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PFP_META2
Sequence: MNKPKKVAILTAGGLAPCLSSAIGSLIERYTEIDPSIEIICYRSGYKGLLLGDSYAVTPKIRENAALLHKFGGSPIGNSRVKLTNVKDCIKRGLVQEGQDPQKVAADQLVKDGVDVLHTIGGDDTNTAAADLAAFLAKNDYGLTVIGLPKTIDNDVFPIKQSLGAWTAAEQGAQYFQNVVAEYNANPRMLIVHEVMGRNCGWLTAATAMEYRKLLDRSEWLPEIGLDRAAYEVHGVFVPEMEIDLAAEAKRLREVMDKVDCVNIFVSEGAGVDAIVAEMQAKGQEVPRDAFGHIKLDAVNPGKWFGEQFAEMIGAEKTLIQKSGYFARASASNVDDIRLIKSCADLAVECAFRRESGVIGHDEDNGNVLRAIEFPRIKGGKPFDIDTPWFVQMLAGIGQSKGARVEVSH
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis.  Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.  Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
What are the official names of this protein?
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase, 6-phosphofructokinase, pyrophosphate dependent, PPi-dependent phosphofructokinase, PPi-PFK, Pyrophosphate-dependent 6-phosphofructose-1-kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'P' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_CORGL
Sequence: MTVPTPYEDLLRKIAEEGSHKDDRTGTGTTSLFGQQIRFDLNEGFPLLTTKKVHFHSVVGELLWFLQGDSNVKWLQDNNIRIWNEWADEDGELGPVYGVQWRSWPTPDGRHIDQISGALETLRNNPDSRRNIVSAWNVSELENMALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQAGLEVGEFIWTGGDCHIYDNHKEQVAEQLSREARPYPTLELNKAASMFEYSFDDITVSGYDPHPLIRGKVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CKLF8_HUMAN
Sequence: MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
What are the official names of this protein?
CKLF-like MARVEL transmembrane domain-containing protein 8, Chemokine-like factor superfamily member 8.
What is the protein family that this protein belongs to?
Belongs to the chemokine-like factor family.
What are the subcellular locations of this protein?
[Isoform 1]: Membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.
Protein: CYHR_CANMA
Sequence: MAAFIKDSFWGQIIYRLSGRKLFRHNDELPDYVVPEKYLLDPKEEVLNSSDKSQSSENKEQTEGDQATIQNEPASEHIIVTWDGDDDPENPYNWPFAWKAIAAMQIGFLTVSVYMASAIYTPGVEEIMNQFNINSTLATLPLTMFVIGYGIGPLFWSPLSENSRIGRTPLYIITLFIFFILQIPTALSNHIAGLSVLRVIAGFFAAPALSTGGASYGDFIAMHYYSIALGVWSIFAVAGPSIGPLIGAAVINRSHDADGWRWSFWFMAILSGVCFIVLSFSLPETYGKTLLRRKAERLRKLTGNNRIISEGELEDGHKTTSQVVSSLLWRPLEITMLEPVVFLIDIYIALVYSIMYLIFESVPIVYAGIHHFTLVEMGATYVSTIIGIIIGGAIYLPTVYYKFTKKLLAGQNVTPEVFLPPAIFGAICMPIGVFIFGWTSSPDINWFVPLIGMALFAVGAFIIFQTLFNYMAVSFKVEYLASVFSSNAFFRSVSAGAFPLFGRALYNNLSIDKFPVGWGSSILGFISLGMIAIPVFFYLNGPKLRARSKYAY
What is the function of this protein?
Probable transporter.  Confers resistance to cycloheximide.
What are the official names of this protein?
Cycloheximide resistance protein.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. CAR1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CATB_PSEAE
Sequence: MNPSLNAFRPGRLLVAASLTASLLSLSVQAATLTRDNGAPVGDNQNSQTAGPNGSVLLQDVQLLQKLQRFDRERIPERVVHARGTGAHGEFVASADISDLSMAKVFRKGEKTPVFVRFSAVVHGNHSPETLRDPRGFATKFYTADGNWDLVGNNFPTFFIRDAIKFPDMVHAFKPDPRSNLDDDSRRFDFFSHVPEATRTLTLLYSNEGTPASYREMDGNSVHAYKLVNARGEVHYVKFHWKSLQGQKNLDPKQVAEVQGRDYSHMTNDLVSAIRKGDFPKWDLYIQVLKPEDLAKFDFDPLDATKIWPGIPERKIGQMVLNRNVDNFFQETEQVAMAPSNLVPGIEPSEDRLLQGRLFAYADTQMYRVGANGLGLPVNRPRSEVNTVNQDGALNAGHSTSGVNYQPSRLDPREEQASARYVRTPLSGTTQQAKIQREQNFKQTGELFRSYGKKDQADLIASLGGALAITDDESKYIMLSYFYKADSDYGTGLAKVAGADLQRVRQLAAKLQD
What is the function of this protein?
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
What are the official names of this protein?
Catalase, Paraquat-inducible catalase isozyme B.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CSRA_DESHY
Sequence: MLALTRKAGERIVIGDNIVVTVVSIKGDSIRLTIDAPKEVKIYRGEIYDAIAAENKEAAVPMDLTELTALKEFHIRK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1342_MYCTO
Sequence: MTAPETPAAQHAEPAIAVERIRTALLGYRIMAWTTGLWLIALCYEIVVRYVVKVDNPPTWIGVVHGWVYFTYLLLTLNLAVKVRWPLGKTAGVLLAGTIPLLGIVVEHFQTKEIKARFGL
What are the official names of this protein?
Uncharacterized protein MT1383.
What is the protein family that this protein belongs to?
To M.leprae ML1176.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APAG_SALSV
Sequence: MINSPRVCIQVQSVYIEAQSSPDDERYVFAYTVTIRNLGRAPVQLLGRYWLITNGHGRETEVQGEGVVGVQPRIAPGEEYQYTSGAVIETPLGTMQGHYEMIDENGDAFTIDIPVFRLAVPTLIH
What are the official names of this protein?
Protein ApaG.
Protein: PDXB_SALTY
Sequence: MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPINFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKDGPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDLNVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQRVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDETAAALLCKLGFNAVHHPAH
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD_THET2
Sequence: MREEFLEEIPLDAPPEEAKELRTEVMTLNVGPQHPSTHGVLRLMVTLSGEEVLEVVPHIGYLHTGFEKTMEHRTYLQNITYTPRMDYLHSFAHDLAYALAVEKLLGAVVPPRAETIRVILNELSRLASHLVFLGTGLLDLGALTPFFYAFRERETILDLFEWVTGQRFHHNYIRIGGVKEDLPEEFVPELKKFLEVMPHRIDEYEALFAESPIFYERARGVGVIPPEVAIDLGLTGGSLRASGVNYDVRKAYPYSGYETYTFDVPLGERGDVFDRMLVRIREMRESVKIIKQALERLEPGPVRDPNPQITPPPRHLLETSMEAVIYHFKHYTEGFHPPKGEVYVPTESARGELGYYIVSDGGSMPYRVKVRAPSFVNLQSLPYACKGEQVPDMVAIIASLDPVMGDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PRX2_PENRF
Sequence: MATSTETISSLAQPFVHLENPINSPLVKETIRPRNDTTITPPPTQWSYLCHPRVKEVQDEVDGYFLENWKFPSFKAVRTFLDAKFSEVTCLYFPLALDDRIHFACRLLTVLFLIDDVLEHMSFADGEAYNNRLIPISRGDVLPDRTKPEEFILYDLWESMRAHDAELANEVLEPTFVFMRAQTDRARLSIHELGHYLEYREKDVGKALLSALMRFSMGLRLSADELQDMKALEANCAKQLSVVNDIYSYDKEEEASRTGHKEGAFLCSAVKVLAEESKLGIPATKRVLWSMTREWETVHDEIVAEKIASPDGCSEAAKAYMKGLEYQMSGNEQWSKTTRRYN
What is the function of this protein?
Aristolochene synthase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699, PubMed:27921136).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:8440737, PubMed:15186158, PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699, PubMed:26274339).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase ORF6 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699, PubMed:27921136).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase ORF8 (PubMed:16345540, PubMed:24239699, PubMed:27921136).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:16345540, PubMed:24239699).  The cytochrome P450 monooxygenase ORF5 also plays a role in this step (PubMed:27921136).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:16345540, PubMed:24239699).
What are the official names of this protein?
Aristolochene synthase, AS, PR-toxin biosynthesis cluster protein 2, Sesquiterpene cyclase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: CRCB_PSEP1
Sequence: MIALIAAVSAGGIAGTLLRFATTNWVAAHWPRHFYAGTLAVNLVGCLLIGLLYGLFLHKPLAPVELRAGLIVGFLGGLTTFSSFSLDTVRLMESGQVPLALGYTSISVVGGLLATWAGLSLTRF
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLPX_BRUAB
Sequence: MSKVSNGGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSMVKSREGVPTPQEIMAVLDDYVIGQKDAKRVLSVAVHNHYKRLAHQSKNSDIELAKSNILLVGPTGCGKTYLAQTLARIIDVPFIMADATTLTEAGYVGEDVENIILKLLQAADYNVERAQRGIVYIDEVDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLDRIISARGEKTSIGFGATVKSVDERRIGEVFKELEPEDLLKFGLIPEFVGRLPVIATLEDLDVDALVQILTEPKNALVKQYQRLFDMENVELVFHDDALRAIANKAVERKTGARGLRSIMEKILLDTMFELPTLEGVREVVISGDVVDGSARPLYIYAERQDEKGNVSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RL27_THET2
Sequence: MAHKKGLGSTKNGRDSQAKRLGVKRYEGQVVRAGNILVRQRGTRFKPGKNVGMGRDFTLFALVDGVVEFQDRGRLGRYVHVRPLA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: LHA_RHORU
Sequence: MWRIWQLFDPRQALVGLATFLFVLALLIHFILLSTERFNWLEGASTKPVQTSMVMPSSDLAV
What is the function of this protein?
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
What are the official names of this protein?
Light-harvesting protein B-870 alpha chain, Antenna pigment protein alpha chain, LH-1.
What is the protein family that this protein belongs to?
Belongs to the antenna complex alpha subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.