PharMolix/UniProtQA huggingface dataset:
Protein: RASK_MOUSE
Sequence: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQELARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCVIM
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity).  Plays an important role in the regulation of cell proliferation (PubMed:6474169, PubMed:1352876).  Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).
What are the official names of this protein?
GTPase KRas, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Endomembrane system. Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2B]: Cell membrane; Lipid-anchor.
Protein: RBS_CYAM1
Sequence: MRVTQGTFCYLPDLTDEQIRKQIQYAINQGWAVSVEYTDDPHPRNSYWEMWGLPLFDVKDPATIMFEVQECRKQFPNHYIKVLAFNSTKGIESTALSFIVNRPANEPGFVLRRIESNDRVQRYQIHSYATEKPEGSRY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DCDB_HALH5
Sequence: MILSGKTISEKLTEKELEITPLTEEQIQPASVDLRLGPHFVTIDDSKEAVISFERPIRYREWTTSDETIVLPPHTFLLATTMETVKLPNHLTAFVEGRSSVGRLGLFIQNAGWVDPGFNGQITLELFNANRLPIELPIGRRICQLVFAEVTGEVAPYQGKYLFQKGATMSEIYKDAF
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RS11_PHEZH
Sequence: MAKEPARVKRRERKNITSGVAHVNASFNNTMVTITDAQGNTISWSSAGLMGFKGSRKSTPYAAQMAAEDAGRKAAEHGVRTLEVNVSGPGSGRESALRALQAVGMTITTIRDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: GAT15_ARATH
Sequence: MLDPTEKVIDSESMESKLTSVDAIEEHSSSSSNEAISNEKKSCAICGTSKTPLWRGGPAGPKSLCNACGIRNRKKRRTLISNRSEDKKKKSHNRNPKFGDSLKQRLMELGREVMMQRSTAENQRRNKLGEEEQAAVLLMALSYASSVYA
What is the function of this protein?
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
What are the official names of this protein?
GATA transcription factor 15.
What is the protein family that this protein belongs to?
Belongs to the type IV zinc-finger family. Class B subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DUT_CHLCH
Sequence: MLNIKIVRLHPLATLPAYATAHAAGMDVAACLEAPVSVAPFSTALIPTGFALELPIGYEAQLRPRSGLALRSMISLPNTPATIDADYRGEVKVILINYGKEPFMVQHGDRIAQMVIARVEQVQFEEVAELSATVRGEGGFGHTGIASVQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RIP21_CRIRI
Sequence: IIEKLVNTALGLLSGL
What is the function of this protein?
Has antibacterial activity against the Gram-positive bacterium L. lactis (MIC=25 uM).  Lacks antibacterial activity against the Gram-negative bacteria E. cloacae and E. coli, and against the Gram-positive bacteria B. cereus, E. faecalis, L. innocua, M. luteus, S. aureus, S. epidermidis and S. uberis.  Does not inhibit the formation of NO by neuronal nitric oxide synthase.
What are the official names of this protein?
Riparin-2.1.
What are the subcellular locations of this protein?
Secreted.
Protein: DBP2_ASPOR
Sequence: MSYNGGYQRDQRDSYRNGGGGGYSNGYSNGNSNGYSGGGSGGGYGGGYGGGGYGGGYGGRGGGAGGGDRMSNLGAGLKKQEWDLDSLPKFEKSFYKEHPDVANRSQRDVDEFRKKFEMSVQGKNIPRPVETFDEAGFPQYVLSEVKAQGFERPTAIQSQGWPMALSGRDVVGIAETGSGKTLSYCLPAIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQAEITKFGKSSRIRNTCVYGGVPKGPQIRDLSRGVEVCIATPGRLIDMLEAGRTNLRRVTYLVLDEADRMLDMGFEPQIRKIISQIRPDRQTCMWSATWPKEVRQLASDFLNDYIQVNIGSMDLSANHRITQIVEVVSDFEKRDKMIKHLEKIMENRGNKCLIFTGTKRIADEITRFLRQDGWPALSIHGDKQQQERDWVLNEFKTGKSPIMVATDVASRGIDVRDITHVLNYDYPNNSEDYVHRIGRTGRAGAKGTAITFFTTDNSKQARDLVTILTEAKQQIDPRLAEMVRYSGGGGGGRGGYGRWGGRGGGRGRGGNYTASNAAPLGGNRRW
What is the function of this protein?
ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
What are the official names of this protein?
ATP-dependent RNA helicase dbp2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GUX1_TRIHA
Sequence: MYRKLAVISAFLAAARAQQVCTQQAETHPPLTWQKCTASGCTPQQGSVVLDANWRWTHDTKSTTNCYDGNTWSSTLCPDDATCAKNCCLDGANYSGTYGVTTSGDALTLQFVTASNVGSRLYLMANDSTYQEFTLSGNEFSFDVDVSQLPCGLNGALYFVSMDADGGQSKYPGNAAGAKYGTGYCDSQCPRDLKFINGQANVEGWEPSSNNANTGVGGHGSCCSEMDIWEANSISEALTPHPCETVGQTMCSGDSCGGTYSNDRYGGTCDPDGCDWNPYRLGNTSFYGPGSSFALDTTKKLTVVTQFATDGSISRYYVQNGVKFQQPNAQVGSYSGNTINTDYCAAEQTAFGGTSFTDKGGLAQINKAFQGGMVLVMSLWDDYAVNMLWLDSTYPTNATASTPGAKRGSCSTSSGVPAQVEAQSPNSKVIYSNIRFGPIGSTGGNTGSNPPGTSTTRAPPSSTGSSPTATQTHYGQCGGTGWTGPTRCASGYTCQVLNPFYSQCL
What is the function of this protein?
Exocellobiohydrolases (CBH) that catalyzes the hydrolysis of 1,4-beta-D-glucosidic bonds in cellulose to release the disaccharide cellobiose (PubMed:21876370).  The degradation of cellulose involves an interplay between different cellulolytic enzymes.  Hydrolysis starts with endoglucanases (EGs), which cut internal beta-1,4-glucosidic bonds in cellulose to reduce the polymerization degree of the substrate and create new chain ends for exocellobiohydrolases (CBHs).  The CBHs release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain.  Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units (Probable).
What are the official names of this protein?
Exoglucanase 1, 1,4-beta-cellobiohydrolase, Cellobiohydrolase 7A, Cel7A, Exocellobiohydrolase I, CBHI, Exoglucanase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RBFA_RICCN
Sequence: MKKLTKTHSHRQQKLASIINEALIEILRRGKMLDSRLFDCPLTITKVIVTADLKIANCYFLPFNTKLTIDEIMDALNNSKNAIRNFITNKINMKFSPDIRFHYDHGFDNAIKVAHLLKDL
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_YEAST
Sequence: MSSEPFKNVYLLPQTNQLLGLYTIIRNKNTTRPDFIFYSDRIIRLLVEEGLNHLPVQKQIVETDTNENFEGVSFMGKICGVSIVRAGESMEQGLRDCCRSVRIGKILIQRDEETALPKLFYEKLPEDISERYVFLLDPMLATGGSAIMATEVLIKRGVKPERIYFLNLICSKEGIEKYHAAFPEVRIVTGALDRGLDENKYLVPGLGDFGDRYYCV
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate in the pyrimidine salvage pathway.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UPRTase, UMP pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: ISPH1_RHOPA
Sequence: MFLAQPRGFCAGVVRAIEIVERALEKYGPPVYVRHEIVHNKYVVESLKAKGAIFVEELSEVPPKAVTVFSAHGVARSIEEEAAARDLPVLNATCPLVTKVHNQGKRYTSKGRTLILIGHAGHPEVEGTMGQVPGPVLLVQNLDDVAALTLPPETPVAYITQTTLSVDDTKDIIVALSKKFHDIEGPDTRDICYATQNRQSAVRQMSKLVDLILVVGANNSSNSNRLREIGTEAGIPSYLIADGSELDPAWLDGKKAVGITAGASAPEVLVDDVIEALRRIVPVTVSVLPGREENIEFVLPAELATA
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1, HMBPP reductase 1.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RL5_RAT
Sequence: MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVNGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs.  It also couples ribosome biogenesis to p53/TP53 activation.  As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53.
What are the official names of this protein?
60S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn.
Protein: SRKA_SALPA
Sequence: MNDNAFTFQTLHPETIMDALFEQGIRVDSGLTPLNSYENRVYQFQDEDRRRFVVKFYRPERWSVDQIREEHQFALELVKDEVPVAAPLAFNGQTLLAHQGYHYAIFPSVGGRQFEADNIDQMEAVGRYLGRLHQTGRKRPFTFRPDIGLAEYLFEPRQVFEDAALIPSGQKAAFLKATDTLLSAVTECWRTDFATLRLHGDCHAGNILWRDGPLFVDLDDARNGPAIQDLWMLLNGNKAEQRMQLETIIEAYEEVSEFDTAEIGLIEPLRAMRLVYYLAWLIRRWGDPAFPKNFPWLTGEDYWQRQTTTFIEQTKILHEPPLQLTPMY
What is the function of this protein?
A protein kinase that phosphorylates Ser and Thr residues.  Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species.  Probably involved in the extracytoplasmic stress response.
What are the official names of this protein?
Stress response kinase A, Serine/threonine-protein kinase SrkA.
What is the protein family that this protein belongs to?
Belongs to the SrkA/RdoA protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_BRASO
Sequence: MAVPRRKTSPSRRGMRRSADAIKKPTYVEDKDSGELRRPHHLDLKTGMYKGRQVLKKKDA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: LFG1_ARATH
Sequence: MAKSDIETGGGNELYPGMKESSELRWAFIRKLYSILSLQLLVTVGVSAVVYFVRPIPEFITETHRGLAVFFVILLLPLLLLWPLLAFEKKHPINCIVLSIFTLSISFSVGICCSLSQGRIVLEAAILTAVMVFGLTIYTFWAVKRGHDFSFLGPFLFGALLIILVFTLLQIFHPLGKLSSMIFSGIASIVFCGYIIFDTNQLIKKLNYDEYITAAIRLYLDVMNLFLSLLGIISN
What is the function of this protein?
(Microbial infection) May prevent cell death upon A. alternata f. sp.  lycopersici (AAL) toxin treatment.
What are the official names of this protein?
Protein LIFEGUARD 1, AtLFG1.
What is the protein family that this protein belongs to?
Belongs to the BI1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MTB_CARCW
Sequence: MDPCDCAKTGACNCGATCKCTNCQCKTCKKSCCPCCPSGCSKCASGCVCKDNSCGSSCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein B, MT-B.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: PVK1_ARCTE
Sequence: GSSGLIPFGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, ArcTe-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL2_DESAP
Sequence: MATKKFKPTSPGRRFVTVSDFREVTVTEPEKSLVEPLRKKAGRNFQGRVTVRHRGGGHKRLYRVIDFKRNKDGVPGKVATIEYDPNRSANIALVNYADGEKRYIVAPAGLKVGQEIMSGPQADIKVGNALPLRNIPPGVLIHNIELYPGHGARVVRSAGGSAQLMAKEGDYAHVRLPSGEVRLFPLDCRATIGQVGNVEHENIVIGKAGRARWLGIRPTVRGVVMNPVDHPHGGGEGRSPIGRPPVTPWGKPALGTRTRNKKKASSKLIVKRRTK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: GYRB_BORHE
Sequence: MSYVASNIQVLKGLEAVRKRPGMYIGSVSINGLHHLVYEVVDNSIDEALAGFCDKIEVVINSDNSVTVNDNGRGIPTDVHEEEGISALELVLTKLHSGGKFNKGTYKVSGGLHGVGISVVNALSSFLAVIVSRDGKLFKQTYSRGIPTSEVDIIGVSSARGTKVTFLADSEIFETLEYDFETLSKRLRELAFLNDKIRISIEDRRSGKEKFLEFYFEGGIKAFVDYITNNSKNIQNEPYFIEGSCDDVIVSVGLKWTEGYSDHILSFVNNINTREGGTHVAGFKSGFLKAMSEAFRDSKISKKDVPSLTLDDFKEGLTAVISIKIPEPQFEGQTKGKLGNSYVKKIVETIVHDGLLKVIDDNLLEVDIILNKAIRAARAREAARKARESERKKSAFESLALPGKLADCASKNPAEREIYIVEGDSAGGSAKMGRDRFSQAILPLWGKMLNVEKTREDKVITNDKLIPIIASLGAGVGKTFYIEKLRYHKIIIMADADVDGSHIRTLLLTFFFRYMRELIENGHVYIAMPPLYKLKYENREHYFYDDLEKEAFLGSIETGKRDKVSLQRYKGLGEMNPTQLWETTMNPATRKMKLIKINDAIQAEKIFVTLMGDDVEPRREFIEQNALDVVNLDV
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_DECAR
Sequence: MIVCLDSGNTRIKWGVHDGVKWLAQGAVAHAEVGALSRLVAEWPLPEKVMLANVAGVEAGSRIREQLAAWAPVFHEVRPELRRCGVTNLYKSPERLGVDRWCALLGARSLVDSATVVVMAGTATTIDTLDADGNFLGGVIMPGIGLMLRSLAHGTAALPFADGEYATYPRCTDDAIVTGVIDAQAGAIERIFSRLDDPAASCLLSGGYAEQIAVHLVVRHRLADNLPLEGLRHLALKS
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSA_GEOKA
Sequence: MIDMRSIQKSFGANIVLNGVDFEVLPGEVHALMGENGAGKSTLIKVLTGIYERDGGTIVVNGREVHYRHPKEAERDGIVVIHQELNVIPTLTVAENIFLGREPKIGRTGVIRYKEMEQQAASYLRRLGMDLDPRELAGRLSVGKQQMIEIARAISTNAKCLIMDEPTAALTEREIQALFSVIPTLKQQGVAVVYISHRMEEIFTICDRISVLRDGQFIGTKRVKETNFDEIVQMMVGRQIGERFPKRRVTIGEERLRVERLTKKGLFENVSFSVRAGEVLGVAGLMGSGRTEIMEAIFGARPFDEGDIYIDGRPVRIRSPRQAVEHGIAMITEDRKQKGLILEMSVHENLTLPKLEQLATAGFIQSSKERDVVLTYIHLLNIKASSPDLPVKALSGGNQQKVVFGKWLAMNPRILILDEPTRGVDVGAKKEIYEVINELAAQGAAIIMISSELPEVLGMSDRVMVVHEGKVQAILENDGLDQETIMRAATGGNR
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SYFA_METTH
Sequence: MMDLDRIIDQLHIYEKKVLKAFEGSDKPLKPEEIAESQKIDIKSVMSASGALESRGFVRVMKDADEVVSLTEDGESCAREGLPERRLIEALKGEEELEMSELSRRAGLDKKEAGIGIGWLMRKGWGRISQGMVSAVSDETPERGADERLLELLLERGSVRIRELPDELRGALKDLKGRKGIVDIRKIKRHTIELTTEGRKLLERGIEIVEEATQVTHEHLKSGAWRKLHYRGYNIDAEYPLVYPGKMHPLRRIIDEIRSIFLKLGFTESRGPIVESAFWNFDCLFQPQDHAAREMQDTFYVKNPAVTDLPCEDLVRAVQDAHETGGSTGSEGWQYEWDRDVARQSVLRTHTTCVSARFLSENEPPLKMFSVGRVFRRETITYKHLPEFHQVEGIVAGDEVNFRNLLGILREFYRKLGFEVRFRPAYFPYTYLSTECEIYLPEKKSWIELGGAGMFRPEVLEPLGVETPVAAFGLGIERLAMIRFDIKDIRMLYQSDLGWLRGLPVTGDLEL
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_PHOPR
Sequence: MIEADRLISNSFESRDDEVIDRAIRPKLLNDYQGQDHVRGQMEIFIKAAQLREEALDHLLIFGPPGLGKTTLANIVANEMGVSIRTTSGPVLEKAGDLAALLTNLEPNDVLFIDEIHRLSPHVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGITQRLEYYKVDDLKDIVQRSANCLGLSMEEEGALEMAQRARGTPRIANRLLRRVRDYAEVVGNGIICSDTAKKALDMLDVDSSGFDYMDRKLLLAIIDKFMGGPVGLDNLAAAIGEEKDTIEDVLEPYLIQQGFLQRTPRGRIATHRAYLHFGLDIPEAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SYH_UREPA
Sequence: MINYSKPRGTIDLYNKEMNDFKLLENFLLSTTKRYGFQQIKTPVFEFAELFMKSAGESSDLVSKEMYLFKDKSDRWLALRPEGTAGVIRAVVENKLLLNHPLPLKLMYFEPCFRYERPQAGRQRQFHQFGVEVLGTKNIYYDFELIALADTILKKLMISNYILEINYISSPHNRSLWVKSLQEYFHLHRTELTPLSQERITTNPLRILDDKLESQKLVVKQAPKISHFLSNEEKEEFNLIKKMLDDYNIKYYVNEGLVRGLDYYSGLVFEFISTSPKLLGQSTIIGGGRYGELIKQTGGPNYEGIGFGIGIERLLIALSETNKNILNTDDDKYLIAFFDKELENEAIKLTQILRINNQLNVDIILSSTKADKIFKLAQRLNVKKLIILAKKEWSDKKIILKDLLNFKQDLLSLDEIKGIR
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_PSEA8
Sequence: MNGAVPMLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFVAADGSHGQRIILEGEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFLEAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLKAKGADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETIIRHCERQGWDV
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXB_SALPA
Sequence: MAAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTRRFTELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQFEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKSFTFWLAKRLVKTEYVSLPNLLAGRELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAADAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: MURD_NEIMF
Sequence: MTLENKKILVAGLGGTGISMIAYLRKNGAEVAAYDAELKPERVSQIGKMFDGLVFYTGRLKDALDNGFDILALSPGISERQPDIEAFKQNGGRVLGDIELLADIVNRRGDKVIAITGSNGKTTVTSLVGYLCIKCGLDTVIAGNIGTPVLEAEWQREGKKADVWVLELSSFQLENTESLRPTAATVLNISEDHLDRYDDLLDYAHTKAKIFRGDGVQVLNADDAFCRAMKRAGREVKWFSLEHEADFWLERETGRLKQGNEDLIATKDIPLQGLHNAANVMAAVALCEAVGLPREALLEHVKTFQGLPHRVEKIGKKNGVVFIDDSKGTNVGATAAAIAGLQNPLFVILGGMGKGQDFTPLRDALAGKAKGVFLIGVDAPQIRRDLDGCGLNMTDCATLEEAVQTAYAQAEACDIVLLSPACASFDMFKGYAHRSEVFIEAFKAL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.