PharMolix/UniProtQA huggingface dataset:
Protein: OPGG_PSEPK
Sequence: MASVALVGLMSAGQLWAFNLDDVAAKAKDLAGQKYEAPKSNLPAVFRDMKFADYQKIRFLQEKAEWAKDKTPFKLSFYHQGMHFDTPVKINEVTATKVEEIKYDPDRFEFGDVPHDPETTKNLGYAGFRVLYPINKADKQDEIMTLLGASYFRVVGKGHVYGLSARGLAIDTALPSGEEFPRFTEFWVEKPKPADKHLVIYALLDSPRSTGAYKLTLRPGNDTVVDVQSRVFLRDHVSRLGIAPLTSMYLFGPNQPSKVLNYRPALHDSEGLSIHAGNGEWLWRPLNNPKHLAVSNFSVENPRGFGLMQRQRAFSDYEDLDDNYQKRPSAWIEPKGDWGKGSVDLVEIPTADETNDNIVAFWSPEKLPEPGKPFEYAYRLHWTIDEPKFQAPDLGWVKQTLRSTGDVKQSNLIRQPDGSVAFLVDFAGPALAALPEDAAVRSQISVGDNAEVVENNLRYNPETKGWRLTLRLKVKEANKSTEMRAALVRDVPVEPAKPAQDAKQDKAAAKHAKAEKAVKAEQSAKAEQPAADAAPTNGALATTEKVLTETWSYQLPADE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DRD4_MOUSE
Sequence: MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
What is the function of this protein?
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior.  Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs.  Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (By similarity).  Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (PubMed:24048828).
What are the official names of this protein?
D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AURAB_XENLA
Sequence: MERAVKENHKPSNVKVFHPMTEGPKRIPVSQPPSTQVRPPVTGVSAQRILGPSNVPQRVMMQAQKPVLSNQKPTAQGLLRPATHGHQTSKPQGPNENRNPQQTSHSSTPNMEKKGSTDQGKTLAVPKEEGKKKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDACRVYLILDYAPGGELFRELQKCTRFDDQRSALYIKQLAEALLYCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFETDTHQETYRRISKVEFQYPPYVSEEAKDLVSKLLKHNPNHRLPLKGVLEHPWIVKNSQQPKKKDEPLAGAQ
What is the function of this protein?
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression (By similarity).  Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (By similarity).  Phosphorylates numerous target proteins (By similarity).  Important for microtubule formation and/or stabilization (By similarity).
What are the official names of this protein?
Aurora kinase A-B, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Serine/threonine-protein kinase 6-B, Serine/threonine-protein kinase Eg2-B, Serine/threonine-protein kinase aurora-A, p46XlEg22.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the spindle pole during mitosis especially from prophase through anaphase (By similarity). Partially colocalized with gamma tubulin in the centrosome, from S to M phase (By similarity).
Protein: MYRO2_BREBR
Sequence: DFMFGTSTASGGLAPSGVMNSLEPKGLAYYNNLLNELLKVLFTYFGDRAYAPNSPQRLSLSLSGVFHLLRGTADFYALNHYSSRDKYGLPKLLLTEDGYGDDGQLDDFEKNYLNATLQAMYLMKEQNVTSVHYTVNKCMN
What is the function of this protein?
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
What are the official names of this protein?
Myrosinase 2, Beta-glucosidase 2, Beta-thioglucosidase 2, Beta-thioglucosidase glucohydrolase 2, Myrosinase, Sinigrinase 2, Thioglucosidase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: MERT_STAAU
Sequence: MYLNQRIKFFLERVVRMMDENRSKGNRWGVWAFFGILLVPLLVPLLCCAGPILLVALGSTGIGALFAGATGNWWLTGIFAALAIVMIALILSKLLKNKYNSPEGNGKTKNKTDCCTPPESVDRKHETR
What is the function of this protein?
Involved in mercuric transport.  Passes a mercury ion from the MerP protein to the mercuric reductase MerA.
What are the official names of this protein?
Mercuric transport protein, Mercury ion transport protein.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUN3B_PONAB
Sequence: MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQGSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLCGSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS
What are the official names of this protein?
RUN domain-containing protein 3B.
What is the protein family that this protein belongs to?
Belongs to the RUNDC3 family.
Protein: YQGF_SALAR
Sequence: MSGTLLAFDFGTKSIGVAIGQRITGTARPLPAIKAQDGTPDWTLIERLLKEWQPDEIIVGLPLNMDGTEQPLTARARKFANRIHGRFGVTVTLHDERLSTVEARSGLFEQGGYRALNKGKVDSASAVIILESYFEQGY
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_VIBVU
Sequence: MSIILGIDPGSRVTGYGVIRQNGRHLQYLGSGCIRTSEKDLPGRLKQIYAGVTEIITQFQPDAFAIEQVFMAKNADSALKLGQARGAAIVSAVNHDLPVYEYAARLIKQAVVGTGGADKAQVQHMVQHMLKLPAKPQADAADALGVAICHANTNKTLIALAGQATSAKRGRYR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: MINC_MOOTA
Sequence: MAQDCITIKGTRGGLLILLDASRDFNEIKANLAAKFAAARGFFRGAAFALVPTSPLNSQETAELEAICREHGLVPGNNITLPSRRRPGGNQAAHPDPVALTSTGLPTLLDEGNLRNGQEINYPGHVMWLGDVHQGATIRAGGNILIMGTLKGNAHAGSQGDRSAAIVAYRMEPEQLGIAGIIARSPEQKTRHPYPEIARLVGTRIVIDPYLSPKSSRN
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: RLMH_BDEBA
Sequence: MKFILYNLATAKEPWADEVSELYKKKISFFIPFDIQSLKAKKSAREDADFKRNEESELILKNINSDDYVVLFDERGSVLDSIQFSKKVENILGSSKKRAIFIIGGAFGVNEEVRKRADLKVALSPMVMNHLMAQAMSLEQIYRAFTIIKKIPYHNI
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPA_BORA1
Sequence: MDHCPRLYLASASPRRRELLTQVGLAHTVLHLPAPPGEDEPQWPGEAAADYVLRTARDKAQRGQIWMREQNLPALPLLAADTTVILDGRVLGKPADRSDAVAMLAALSGTKHEVRTAVVLVHEDRLYEAVSITHVSMRALTAAERERYCDSGEPYGKAGAYGIQGLAGSFISHIDGSYSGVMGLPLFETAELLRRAGIALP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_GLAP5
Sequence: MVKKIAVLTSGGDAPGMNAAIRGVVRAGLSEGLEVYGIQDGYYGLYHDRVIKLERRSVSEVINRGGTFLGSARFPEFKNPEVRAKCVETLKKYEIDALVVIGGDGSYMGAKLLTEEHGIACIGLPGTIDNDVAGTDYTIGFQTALETALEAIDRLRDTSTSHQRISIVEIMGRHCGDLTLSAALAGGCEYIIIPEKGFDKESLIRNIEDGFNKGKRHAIIAITELMTDVHQLAREIEERFGHETRAAVLGHTQRGGAPCAFDRILASRMGVYAVELLMQGYGGRCVGIQNEKLVHHDIIDAITNMRRPFKEEIFNTSRKLF
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_STRPI
Sequence: MDKKTVKVIEKYSMPFVQLVLEKGEEDRIFSDLTQIKQVVEKTGLPSFLKQVAVDESDKEKTIAFFQDSVSPLLQNFIQVLAYNHRANLFYDVLVDCLNRLEKETNRFEVTITSAHPLTDEQKTRLLPLIEKKMSLKVRSVKEQIDESLIGGFVIFANHKTIDVSIKQQLKVVKENLK
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GELS_DROME
Sequence: MDASGAATMAVLSSLLVFLALSSSLCSAGTLNARPAFPVQSGEIQPSGQNSKQAARRVMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGLETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVSDASGKLKVDIIGQKPLTQAMLDTRECFILDTGSGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKKSGGRAFGFMPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEANNGDTGSLTYVWHGVKASAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFKGKLLTSFTALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGASAFEKQAAVDRFSDYWDDVELEQVEEGAEPDEFWEELNGEGQYDRSLGDDGAPLLESRLFHCHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQPSYEDMKQLVIDANNEV
What is the function of this protein?
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping).  It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.
What are the official names of this protein?
Gelsolin.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
[Isoform 2]: Cytoplasm, cytoskeleton. SUBCELLULAR LOCATION: [Isoform 1]: Secreted.
Protein: MNMA_ECOL6
Sequence: MSETAKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWDNVFELFLAEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLCADYIATGHYVRRAXVDGKSRLLRGLDSNKDQSYFLYTLSHEQIAQSLFPVGELEKPQVRKIAEDLGLVTAKKKDSTGICFIGERKFRKFLGRYLPAQPGKIITVDGDEIGEHQGLMYHTLGQRKGLGIGGTKDGTEEPWYVVDKDVENNILIVAQGHEHPRLMSVGLIAQQLHWVDREPFTGTMRCTVKTRYRQTDIPCTVKALDADRIEVIFDEPVAAVTPGQSAVFYNGEVCLGGGIIEQRLPLPV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUTA_SULAC
Sequence: MTYTGKSIKRLNDDKFITGRSNYIDDIKIPSLYAGFVRSPYPHAIIKRIDATDALKVNGIVAVFSGKDINPMLKGGVGVLSAYVNPSLFRFKERKAFPEDNKVKYVGEPVAIVIGQDKYAVRDAIDRVNVEYEQLKPVIKMEDAEKDEVIVHDELKTNVSYKIPFKAGDIEKAFSQADKVVKVEAINERLIPNPMEPRGILSVYDGNSLSVWYSTQVPHFARSEFARIFGIPETKIRVAMPDVGGAFGSKVHIMAEELAVIASSILLRRPVRWTATRSEEMLASEARSNVFTGEVAVKKDGTVLGIKGKLLLDLGAYLTLTAGIQPTIIPVMIPGPYKVRDLEIESTAVYTTTPPITMYRGASRPEATYIIERIMSTVADELGLDDVTIRERNLIDQLPYTNPFGLRYDTGDYIRVFKDGVAKLEYNELRKWAQQERSKGHRVGVGLAFYLEICSFGPWEYGEIKVDNKGNVLVITGTTPHGQGTETAIAQIVADALQIPIEKIRVVWGDTDIVEGSFGTYGSRSLTIGGSAALKVAERVLDKMKRAAASYFNADVQEIRYENEEFSVKNDPSKKASWDEIASLATTKEPIVEKIYYENDVTFPYGVHVAVVEVDDLGMARVVEYRAYDDIGKVINPALAEAQIHGGGVQGVGQALYEKAIINENGQLSVTYADYYVPTAVEAPRFISYFADKSHPSNYPTGTKGVGEAALIVGPAAIIRAIEDAVGARFTKTPTPPEEIYKAIMSKK
What is the function of this protein?
Component of the glyceraldehyde dehydrogenase which is involved the nonphosphorylated Entner-Doudoroff pathway.  Catalyzes the oxidation of D-glyceraldehyde to yield glycerate.  When the artificial electron acceptor 2,6-dichlorophenol-indophenol (Cl2Ind) is used, the enzyme shows a broad substrate range (glyceraldehyde-3-phosphate, formaldehyde, acetaldehyde, propionaldehyde and isobutyraldehyde), but is most active with D-glyceraldehyde.  It is not known which acceptor is utilized in vivo.
What are the official names of this protein?
Glyceraldehyde dehydrogenase large chain, Glyceraldehyde dehydrogenase subunit A, Glyceraldehyde dehydrogenase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPB_AZOVD
Sequence: MTETSYRTGPDEKGLFGRFGGQYVAETLMPLILDLAEEYERAKVDPAFLEELAYFQRDYVGRPSPLYFAERLTEHCGGAKIYLKREELNHTGAHKINNCIGQILLARRMGKQRIIAETGAGMHGVATATVAARFGLQCVIYMGTTDIDRQQANVFRMKLLGAEVIPVTAGTGTLKDAMNEALRDWVTNVETTFYLIGTVAGPHPYPAMVRDFQAVIGKETREQLIEKEGRLPDSLVACIGGGSNAMGLFHPFLDEPGVKIVGVEAAGHGIETGKHAASLNGGVPGVLHGNRTFLLQDADGQIIDAHSISAGLDYPGIGPEHAWLHDIGRVEYSSITDHEALQAFHTCCRLEGIIPALESSHALAEVFKRAPRLPKDHLMVVNLSGRGDKDMQTVMHHMQEKLEKHA
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: ATSK_ACIAD
Sequence: MTTFIQNPTQQLQLRKLTGRIGAEISGIHLSSELDSSTVQFIHDALLEHKVLFFRGQQHLGDTEQEKFAELFGSPVKHPTVPAADGTDFIFELDSQKGARANSWHTDVTFVDAYPKISILRGLIIPETGGDTTWANTETAYEDLPELLKQFAEQLVAVHSNEYDYGGPKQNVEPEQLERLKKVFVSTKYETEHPVVIVHPETGKKSLLLGHFFKRLVGFSQSDSQLLFNILQEKVTRPENTVRWQWQEGDVVIWDNRSTQHYAVNDYGDQHRVVRRITLAGEVTTGAHGLKGKTTLPKDLSAEQLEKAKLHAVLNAN
What is the function of this protein?
Alpha-ketoglutarate-dependent dioxygenase that in vitro catalyzes the oxygenolytic release of sulfite from hexylsulfate.
What are the official names of this protein?
Alkylsulfatase.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
Protein: ACOT1_HUMAN
Sequence: MAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPLAVELEVLDGHDPDPGRLLCRVRHERYFLPPGVRREPVRAGRVRGTLFLPPEPGPFPGIVDMFGTGGGLLEYRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAVNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLRYKGETLPPVGVNRNRIKVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKPQIICYPETGHYIEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGGHEGTIPSKV
What is the function of this protein?
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels.  More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20).
What are the official names of this protein?
Acyl-coenzyme A thioesterase 1, Acyl-CoA thioesterase 1, CTE-I, CTE-Ib, Inducible cytosolic acyl-coenzyme A thioester hydrolase, Long chain acyl-CoA thioester hydrolase, Long chain acyl-CoA hydrolase, Palmitoyl-coenzyme A thioesterase.
What is the protein family that this protein belongs to?
Belongs to the C/M/P thioester hydrolase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: YVAT_VACCC
Sequence: MDIKNLLTACTIFYITTLATADIPTPPPTGHVTRENILIRGIINVVIGVHLENLPRLDVMVTITQNVNAAHLIHIPQSQLF
What are the official names of this protein?
Uncharacterized 8.9 kDa protein.
Protein: REV_HV1B8
Sequence: ELIEAVRLIKFLYQSNPPPKPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTVLESGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: ENO_CROS8
Sequence: MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVGAVNGPIAQAIVGKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAASKGMPLYEHIAELNGTPGKFSMPVPMMNIINGGEHADNNVDIQEFMIQPVGASSVKEAIRMGSEVFHHLAKVLKGKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRREIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: PSBM_PROM3
Sequence: MPVNNFGFLATLLFVAVPMLFLIGLYIQTNSNKS
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: HLDD_SALAR
Sequence: MIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKEGTKFVNLVDLNIADYMDKEDFLIQIMSGEELGDIEAVFHEGACSSTTEWDGKYMMDNNYQYSKELLHYCLEREIPFLYASSAATYGGRTSDFIESREYEKPLNVYGYSKFLFDEYVRQILPEANSQIVGFRYFNVYGPREGHKGSMASVAFHLNTQLNNGESPKLFEGSENFKRDFVYVGDVADVNLWFLESGKSGIFNLGTGRAESFQAVADATLAYHKKGSIEYIPFPDKLKGRYQAFTQADLTNLRNAGYDKPFKTVAEGVTEYMAWLNRDA
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.