PharMolix/UniProtQA huggingface dataset:
Protein: ARI1_XENTR
Sequence: MDSDEGYNYEFDDEEECSEDSGADEHEDDLELGEVELVEAGLSGSERAGICGEGGGSALGPGPGGEEEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFSECHVINPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIIEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRSTLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLLHVHEGYEKDLWEYIED
What is the function of this protein?
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3.  Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets.  The initial ubiquitin is then elongated.  E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes.
What are the official names of this protein?
E3 ubiquitin-protein ligase arih1, Protein ariadne-1 homolog, ARI-1, RING-type E3 ubiquitin transferase arih1.
What is the protein family that this protein belongs to?
Belongs to the RBR family. Ariadne subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BPT_XANC5
Sequence: MAIHADTHDDLRLFQTGEHACGYWSDRQARDLVLDPHDPRLGAIYPQALAWGFRRSGDLVYRPHCERCRACVPVRIAVAAFHPDRSQRRCLARNQDLVVRVVAAERTDEQLALYRHYLKHRHPGGGMDEHGATEFDQFLIGGWSHGRFLEIREPAIAHLPGRLLAVAVTDVTGHALSAVYTFYTPEAAARSLGTFAILQQIQWAQRERRAHLYLGYWIDGHAKMNYKRRFSALEAYDGRHWRGLPAHASVD
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPR_MOUSE
Sequence: MPVKRSLKLDDQFEKNSFSPSKIVRKKSITAYSPTTGTYQLSPFSSPATPKEQEHRNGPSNETRKRSNLSSPVRQESTVKDRDGFMVLLSKIEISSEKTMEIMKNLSSIQALEGNRQLEDLIGVSLVPCSLKSEARKTKELMTKVIKQKLFEKKKSRITPKDHHLDSFEFLKAILN
What is the function of this protein?
Transcription coregulator that can have both coactivator and corepressor functions.  Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion.  In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid.  Acts as a coactivator for estrogen receptor alpha.  Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1.  Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases.  May also act as an inhibitor of cyclin A-associated kinase.  Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity).
What are the official names of this protein?
Centromere protein R, CENP-R, Nuclear receptor-interacting factor 3.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Protein: KAD2_MALGO
Sequence: MSNPANTELSYLKSLVNELNEKIAVLEGKAPANQGVRMVLVGPPGAGKGTQAPKILERFQNMVCHLATGDLLRQQVAMGTDLGKQAKKIMDQGALVSDEIMVGMIKDQLETNRSCKKGFILDGFPRTTPQAEKLDQMLSDRKQKLDHVIELQIPDELLISRITGRLIHPGSGRSYHKIFSPPKQPMKDDITGEPLVQRSDDNEEALRKRLATYHKQTTAVTDYYKKHGIWSPIDATQSPNTVWQSISAIFNNGASA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: PPNP_PSE14
Sequence: MFKVNEYFDGTVKSIAFSQVDGQATIGVMAAGEYEFGTAQREIMHVISGELNVKLPDSTDWETFSTGSQFNVPANSKFQLKVSVDTAYLCEYR
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: YK100_YEAST
Sequence: MIKVPLPDVIFVAHRNKHTRQGNITQTKY
What are the official names of this protein?
Uncharacterized protein YKL100W-A.
Protein: ROX1_YEAST
Sequence: MNPKSSTPKIPRPKNAFILFRQHYHRILIDEWTAQGVEIPHNSNISKIIGTKWKGLQPEDKAHWENLAEKEKLEHERKYPEYKYKPVRKSKKKQLLLKEIEQQQQQQQKEQQQQKQSQPQLQQPFNNNIVLMKRAHSLSPSSSVSSSNSYQFQLNNDLKRLPIPSVNTSNYMVSRSLSGLPLTHDKTARDLPQLSSQLNSIPYYSAPHDPSTRHHYLNVAQAQPRANSTPQLPFISSIINNSSQTPVTTTTTSTTTATSSPGKFSSSPNSSVLENNRLNSINNSNQYLPPPLLPSLQDFQLDQYQQLKQMGPTYIVKPLSHTRNNLLSTTTPTHHHIPHIPNQNIPLHQIINSSNTEVTAKTSLVSPK
What is the function of this protein?
Transcription factor that represses the expression of HEM13, COX5B, ANB1, CYC7 or AAC3 (hypoxic function).  Binds to the DNA sequence 5'-RRRTAACAAGAG-3'.
What are the official names of this protein?
Repressor ROX1, Heme-dependent repression factor, Hypoxic function repressor.
What are the subcellular locations of this protein?
Nucleus.
Protein: OPRD_HUMAN
Sequence: MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
What is the function of this protein?
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Signaling leads to the inhibition of adenylate cyclase activity.  Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.  Plays a role in the perception of pain and in opiate-mediated analgesia.  Plays a role in developing analgesic tolerance to morphine.
What are the official names of this protein?
Delta-type opioid receptor, D-OR-1, DOR-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KAD_NITWN
Sequence: MRLILLGPPGAGKGTQAQRLVHHYGIIQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDDVVIGIISDRLEQADAKDGFILDGFPRTVPQAEALDILLQSKNLALDAVIELRVDESALLQRVENRVAETTARGEQVRADDNPEVLSQRLASYRALTEPLIRYYSERGRLLTVDGMMAIDDVTRDIRRVLRRSGVPMSKFGVRRW
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSA_PHOPR
Sequence: MNQPILELKGIEKAFPGVKALDNACLNVYPGKVMALMGENGAGKSTLMKSLTGIYAMDAGEIRYQGKAVNFDGPRHSQEAGISIIHQELNLIPELTIAENIFLGREKTNAFGGIKWAEMFREADDLLKRLNVKHHSRQLLGELSLGEQQMVEIAKALSFKSQVIIMDEPTDALTDTETESLFKVINELRAEGCGIVYISHRLKEIFEICDDITVLRDGKFIGERAVADTDEDGLIEMMVGRRLDEQYPRIDVRHGETCLEVTNLTGAGVNNVSFKLDRGEILGVSGLMGAGRSELMKVIYGALKRESGDIKLNGKTINPVTPQDGLANGIAYISEDRKGDGLVLGLSVKENMSLCSLEQLSKGVQLKHYEEVTAVEDFIRLFNIKTPTRDQIIGNLSGGNQQKVAIAKGLMTRPKVLILDEPTRGVDVGAKKEIYQLINQFKAEGMSIILVSSEMPEVLGMSDRIIVMHEGRISGEFMAADANQEKLLACAVGKTTEQNNEVAA
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ADSL4_ARATH
Sequence: MCDPTRDDGSSRSRVVSTMQKRAYFQRQWPLVDVVRASVVVIVHFLCLLAPFNFKWEALRFGLVLFALTTLSITFSFHRNLSHRSFKIPKWLEYPWAYSAVFALQGDPMDWVSIHRFHHQFTDSDRDPHSPKEGLLFSHILWIFDTQYIKYKCGGRDNVLDLKKQWFYKFLRRTIAVHILMFWTILYLYGGLPYLTCGGGVGIFIGYHVTWLVNSACHIWGSRSWNTKDTSRNVWWLSLFTMGESWHNNHHAFESSARQGLEWWQIDITWYLIRLFEVLGIATDVKLPSELQKQKMALVR
What are the official names of this protein?
Delta-9 desaturase-like 4 protein.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PLGF_RAT
Sequence: MLAMKLFTCFLQVLAGLAVHSQGALSAGNNSTEMEVVPFNEVWGRSYCRPMEKLVYIADEHPNEVSHIFSPSCVLLSRCSGCCGDEGLHCVALKTANITMQILKIPPNRDPHSYVEMTFSQDVLCECRPILETTKAERRKTKGKRKQSKTPQTEEPHL
What is the function of this protein?
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration.  It binds to the receptor FLT1/VEGFR-1.  Also promotes cell tumor growth (By similarity).
What are the official names of this protein?
Placenta growth factor, PlGF.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted.
Protein: SMT2_ARATH
Sequence: MDSLTLFFTGALVAVGIYWFLCVLGPAERKGKRAVDLSGGSISAEKVQDNYKQYWSFFRRPKEIETAEKVPDFVDTFYNLVTDIYEWGWGQSFHFSPSIPGKSHKDATRLHEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDALCEVVCGNFLQMPFDDNSFDGAYSIEATCHAPKLEEVYAEIYRVLKPGSMYVSYEWVTTEKFKAEDDEHVEVIQGIERGDALPGLRAYVDIAETAKKVGFEIVKEKDLASPPAEPWWTRLKMGRLAYWRNHIVVQILSAVGVAPKGTVDVHEMLFKTADYLTRGGETGIFSPMHMILCRKPESPEESS
What is the function of this protein?
Catalyzes the methyl transfer from S-adenosyl-methionine to the methylene group of 24-methylene lophenol to form 24-ethylidene lophenol.
What are the official names of this protein?
24-methylenesterol C-methyltransferase 2, 24-sterol C-methyltransferase 2, Sterol-C-methyltransferase 2, Protein COTYLEDON VASCULAR PATTERN 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
Protein: PTH_LATSS
Sequence: MKMIVGLGNPGSKYAKTKHNIGFMVIDQLCEKYNVTLNKHDFEAEYGSFKYEGETVLLVKPLTFMNDSGRSVGPLMSYYQVGIDELLVIQDDMDLTMGKLRLRQKGSAGGHNGIKSIIAHTKSQTFKRLKIGIQHPQKSTVVNWVLTPFDKDGAPVINQAIDQACEAIDDWCQNDDFMKTMNKFN
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2AZ_NEOFI
Sequence: MPGGKGKSVGGKAGAKDAAGKTQKSHSAKAGLQFPCGRVKRFLKNNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPRINRALLLKVEQKKKNKSDA
What is the function of this protein?
Variant histone H2A which can replace H2A in some nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received.  Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins.  Required for the RNA polymerase II and spt15/TBP recruitment to the target genes.  Involved in chromosome stability (By similarity).
What are the official names of this protein?
Histone H2A.Z.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CRR7_ARATH
Sequence: MECSLQKQLFNNGDKLFSSRHNRRVSIEQVHVTDSLSVNSINLFHKPICYPISSIITSRKSKSHFSVCATRRRRVHSNSDTYVLLEAGQDEQFVTEDELKAKLRGWLENWPVNSLPPDLARFDDLDEAVDFLVKAVCELEIDGEVGSVQWYQVRLE
What is the function of this protein?
Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain.  May function in assembly or stabilization of the NDH complex (PubMed:16359395, PubMed:20444231).  Required for the accumulation of NDH subcomplex A, which is a core part of NDH.  May be involved in post-translational steps during the biogenesis of subcomplex A (PubMed:20444231).
What are the official names of this protein?
Protein CHLORORESPIRATORY REDUCTION 7, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Note=Previously localized in chloroplast thylakoid membrane fraction.
Protein: CH10_BUCGU
Sequence: MKIRPLHDRVIVKRKEAESKSAGGIVLTGSAAGKSTRGTVTAVGNGRILDNGSIKPLDVKVGETVIFNEGYGAKIEKIDNEELLILTESDILAIVEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPRS_STAEQ
Sequence: MLNNEYKNSSMKIFSLKGNEPLAQEVADHVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIVQPTSYPVNLHLMELLIMIDACKRASAANINIVVPYYGYARQDRKARSREPITAKLVANLIETAGANRMIALDLHAPQIQGFFDIPIDHLMGVPILAQHFENDPDINPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPKPNVAEVMNIVGDIEGRTAIIIDDIIDTAGTITLAAQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKQLIVTNSIQLEENRKPNNTKELSVAGLIAKAIIRVYERESVSVLFD
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SKAP2_TAKRU
Sequence: MLPIPEELTTLISDLELYLADGLKGENLSKKAKEKREAFIKRIKEVKLSFPQDFKDKYAEDSEEEEDWDSNEGGSLQSERTDKDEEACEGAQQAPAVAAQDLTSVFKAGYLEKRRKDHSFFGTEWQKRWCALSGQTFYYYGSEKDKQQKGEFNIEGYRVKMNSSLRKDSKKDFCFEISATDKRSYMFCASSVKEAEEWVKQIDFVLKDMTGIIPEEEEEGQELYDDVGQMDEIYEVLPEEDMPSPPPKVEPVSKHPPPTPAVDKSTDYANYYQGLWDCMGDLPDELSFKRGDAIYILSREYQTFGWWVGEKNGQIGIVPKDYLMELYAL
What is the function of this protein?
May be involved in B-cell and macrophage adhesion processes.  May play a role in src signaling pathway (By similarity).
What are the official names of this protein?
Src kinase-associated phosphoprotein 2, Src family-associated phosphoprotein 2.
What is the protein family that this protein belongs to?
Belongs to the SKAP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_STRTD
Sequence: MRQAEIERNTFETKIKLSLNLDAQDPVDIQTGVGFFDHMLTLFARHGRMSLVVKADGDLWVDSHHTVEDVGIVLGQALKEALGDKAGINRYGTSFVPMDETLGMASLDLSGRSFLVFDASFDNPKLGNFDTELIEEFFQALAFNVQMNLHLKILHGKNNHHKSESLFKATGRALREAITVNPDIHGVNSTKGML
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KV13_RABIT
Sequence: AYDMTQTPSSVSAAVGGTVTINCQASEDISANLAWYQQKPGQPPKLLIYAASDLASGVPSRFKGSGSGTEYTLTISGVQCADAATYYCQSADYSGSAVTFGGGTEVVVKG
What are the official names of this protein?
Ig kappa chain V region 3547.
Protein: PYRD_CELJU
Sequence: MYSHVRDLLFRLNPETSHEFSLDMLGAAERLKLIGLMAAKVPETPVEVMGLRFPNPVGLAAGLDKNGDYFNALGALGFGFVEIGTITPRPQPGNAQPRLFRIPEAKAIINRMGFNNKGVDHLVAQVKKRRYQGILGINIGKNATTPVENAVDDYLTCLRKVYDHADYITVNISSPNTPGLRSLQFGDSLSQLLAPLKKEQGVLQQAGGRYVPIAVKIAPDMDDSEIAQVAGVLLQEGMDGVIATNTTIGREGVEGYDTGKEAGGLSGLPVRDKSTAVIQSLNQCLGGKLPIIGVGGIFDGASAADKVRAGASLVQVYSGFIYEGPALIAAAAAGIASYHQGQ
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TODT_PSEPT
Sequence: MPARWGCLFPGKYPCQTGLRHMSDRASVIYILDDDNAVLEALSSLVRSIGLSVECFSSASVFLNDVNRSACGCLILDVRMPEMSGLDVQRQLKELGEQIPIIFISGHGDIPMAVKAIKAGAVDFFTKPFREEELLGAIRAALKLAPQQRSNAPRVSELKENYESLSKREQQVLKFVLRGYLNKQTALELDISEATVKVHRHNIMRKMKVSSIQDLVRVTERLKDSLE
What is the function of this protein?
Member of the two-component regulatory system TodS/TodT involved in the regulation of toluene degradation.  Phosphorylated TodT activates transcription of the tod operon (todXFC1C2BADEGIH).  Binds specifically to three boxes in the tod promoter region in a cooperative manner.  Boxes-1 and -2 are pseudopalindromes and Box-3 is a half-palindrome.
What are the official names of this protein?
Response regulator protein TodT.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRGM3_MOUSE
Sequence: MDLVTKLPQNIWKTFTLFINMANYLKRLISPWSKSMTAGESLYSSQNSSSPEVIEDIGKAVTEGNLQKVIGIVKDEIQSKSRYRVKIAVTGDSGNGMSSFINALRFIGHEEEDSAPTGVVRTTKKPACYSSDSHFPYVELWDLPGLGATAQSVESYLEEMQISTFDLIIIVASEQFSSNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRENLQQAQVRDPPLFLISCFSPSFHDFPELRNTLQKDIFSIRYRDPLEIISQVCDKCISNKAFSLKEDQMLMKDLEAAVSSEDDTANLERGLQTYQKLFGVDDGSLQQVARSTGRLEMGSRALQFQDLIKMDRRLELMMCFAVNKFLRLLESSWWYGLWNVVTRYFRHQRHKLVIEIVAENTKTSLRKALKDSVLPPEIH
What is the function of this protein?
Immunity-related GTPase that plays important roles in host resistance to acute infection by protozoan, such as Toxoplasma gondii and Leishmania major (PubMed:10639151, PubMed:11500431, PubMed:12438372, PubMed:16940170, PubMed:18765738).  Acts as a dynamin-like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity).  Acts predominantly to restrict acute protozoan infection: expression is required in both hematopoietic and non-hematopoietic cellular compartments and is dependent on Stat1 (PubMed:12438372).  Only plays a partial role in the control of latent Toxoplasma infection (PubMed:12438372).  Involved in the clearance of acute protozoan infections by regulating autophagy, possibly by promoting the fusion of phagosomes with lysosomes for efficient degradation of vacuoles containing parasites (PubMed:16940170).  Probably involved in membrane disruption of parasite-containing vacuoles (PubMed:18765738).  In addition to its role in resistance to acute infection by protozoan, also acts as a negative regulator of the integrated stress response (ISR) following coxsackievirus B3 infection (PubMed:21981022).  Promotes differentiation of activated CD8(+) T-cells (PubMed:25644000).
What are the official names of this protein?
Immunity-related GTPase family M protein 3, Interferon gamma-induced GTPase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
Protein: RL18_SULIK
Sequence: MANGPNYKIKPRRRREGKTNYYKRYVYVISKQIRFIVRITNKYVIVQIAKIDPKGDIMVASAHSSELTKKFEWKGDENNTPSAYLTGYLAALRAVKKGVTECVADIGLHVPSKGNKVFYAIKGAIDAGLKIPIGDISIENDRIKGEHIAKYAEKLKSENLDLYNKLFSRYLGRGLNPENLPSHFEEILNKIKSSGG
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: APT_MESH7
Sequence: MQINLEKYIRTVEDFPKKGISFKDISPLLADGKALNYTIVEMASLAKDVDIIVGPDARGFLFGTPTAAFLSKPFIMIRKAGKLPGEVEEFAYELEYGSAILEVQVDMIKPGQKVAIIDDVLATGGTVKAITKMIERAGAIVDKIIFLIELEQLQGRKKLENYDVISLIKIS
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_STAA2
Sequence: MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSKLDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYIKSLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPEHSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSKIQEAFKDRILIPKNNLDYVPKKNKVLYSFEQQKIEFEQRQNTENNQEKTFSSEESNSKSFMAENQNDEIVIKEDSYNPFVTKTSESLITDDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNEDASVQNYENKASDDYYDVNDIKGTKSKDPKRRIPYMEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIMLEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREAEDPFTCPHGRPIIINFSKYELEKLFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.