PharMolix/UniProtQA huggingface dataset:
Protein: YQGF_MAGSA
Sequence: MPILAPAELLASLSRDQRLLGLDLGSKTIGLALSDVSRTIATPFDTIRRTKFTQDAELLLAVVDKQGVGGLVLGLPVEMDGFEGPRCQSVRSFAANLARLRDMPIAYWDERLSTSAVTRTLLEADSSRKRRAEVVDKMAAAYILQGLLDNRSGFA
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END8_ECOL5
Sequence: MPEGPEIRRAADNLEAAIKGKPLTDVWFAFPQLKSYQSRLIGQHVTHVETRGKALLTHFSNDLTLYSHNQLYGVWRVVDTGEEPQTTRVLRVKLQTADKTILLYSASDIEMLTPEQLTTHPFLQRVGPDVLDPNLTPEVVKERLLSPRFRNRQFAGLLLDQAFLAGLGNYLRVEILWQVGLTGNHKAKDLNAAQLDALAHALLDIPRLSYATRGQVDENKYHGALFRFKVFHRDGEPCERCGGIIEKTTLSSRPFYWCPGCQH
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RL23_BURCM
Sequence: MSEIRKNDHRLMQVLLAPVISEKATLVADKNEQVVFEVAPDATKQEVKAAVELLFKVEVDSVNVLVQKGKQKRFGRSMGRRKDVKKAYVCLKPGQEINFEAEAK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RS11_MYCLE
Sequence: MPPKKANAAGPKKGQKTRKREKKNIPYGAAHIKSTFNNTIVTITDQQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQEHGVRKVDVFVMGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: CD53_HUMAN
Sequence: MGMSSLKLLKYVLFFFNLLFWICGCCILGFGIYLLIHNNFGVLFHNLPSLTLGNVFVIVGSIIMVVAFLGCMGSIKENKCLLMSFFILLLIILLAEVTLAILLFVYEQKLNEYVAKGLTDSIHRYHSDNSTKAAWDSIQSFLQCCGINGTSDWTSGPPASCPSDRKVEGCYAKARLWFHSNFLYIGIITICVCVIEVLGMSFALTLNCQIDKTSQTIGL
What is the function of this protein?
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion.  May be involved in growth regulation in hematopoietic cells (By similarity).
What are the official names of this protein?
Leukocyte surface antigen CD53, Cell surface glycoprotein CD53, Tetraspanin-25, Tspan-25.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane. Cell junction. Membrane; Multi-pass membrane protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.
Protein: GARL_SALAR
Sequence: MNNAIFPNKFKVALAAQQVQIGCWSALASPITTEVLGLAGFDWLVLDGEHAPNDVTTLIPQLMALKGSASAPVVRVPTNEPVIIKRMLDIGFYNFLIPFVETQEEAARAVASTRYPPEGIRGVSVSHRANMFGTVPDYFAQSNKNITIIVQIESQLGVDNVDAIAATEGVDGIFVGPSDLAAAMGHLGNASHPDVQQTIQHIFARAKAHGKPCGILAPVEADARRYLEWGATFVAVGSDLGVFRAGTQKLADTFKK
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
What are the official names of this protein?
5-keto-4-deoxy-D-glucarate aldolase, KDGluc aldolase, KDGlucA, 2-dehydro-3-deoxy-D-glucarate aldolase, 2-keto-3-deoxy-D-glucarate aldolase, 5-dehydro-4-deoxy-D-glucarate aldolase, Alpha-keto-beta-deoxy-D-glucarate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
Protein: DHPS_NEIMA
Sequence: MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
What is the function of this protein?
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
What are the official names of this protein?
Dihydropteroate synthase, DHPS, Dihydropteroate pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the DHPS family.
Protein: PQQC_CERS4
Sequence: MSLDLSTSLSPARPLESADAMEERLREIGAARYHDRHPFHHMLHGGELTKGQVQAWALNRYYYQCTIPVKDAVVISRFRDRATRIEWRHRLEDHDGAEGAEGGIDRWLILTDGLGLDRAYVESTEGILPATRFAVEAYVHFVRDRSPLEAIASCLTELFAPNIHATRISGMLSHYDFINPTVMAYFQRRLTQAPRDADYALRYVRDHARTPEERAAVCNALIFKTQVLWTQLDALHHAYVLGHVPPGAFVPEEMR
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: ATG34_YEAST
Sequence: MKIAVETTLFDFFVIDQFKKSTFSAPNTKVDTIKGCINKFIEQFNVYDEQHIFWQPPGKSNVRLLSNANDFGQLGNFLHKKIKCNIFIGEEALRKYDLNICGPYDKFVENSDPSVKKVVNRDDVMLSRKCLNIISEQLSILEKSISKAQNQVLQSSEVEGKKCIILPEDKPELIKFFSKFETSVQLQEVYEGYKVYEKLLQKFGGQKKRMESFLNENTPMSGAEAIKQINISEELKEKGERLTTPNDPLLHVEVSNEDNSLHFILYNKTNIIIPGNCTFEFSSQISEVFSIKMGPHEIGIKGQKELWFFPSLPTPLSNYTMKVVNQDGETILVGKCADSNEITLKSPLASFSTGSFQTGSFHTLQDPTNVFRADALSSPDESSIMSTPFLGETDEVYNSGSTLSRPFTWEEI
What is the function of this protein?
Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy.  Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.
What are the official names of this protein?
Autophagy-related protein 34.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Membrane-associated protein found in pre-autophagosomal structure and other perivacuolar punctate structures.
Protein: LIPB_PARXL
Sequence: MCATPVSPTPLPATAPLALRWRGTEPYEASFEAMRAFTDGRTAETPDEIWLVEHPPVFTLGQAGDPAHLLAADSGIPLVKVDRGGQITYHGPGQVVAYLLLDLRRRKLMVRELVTRIEQAVIDTLAAYNLAGERKAGAPGIYVAPGPAAGSHAGAKIAALGLKIRNGCSYHGVSLNVNMDLRPFLAINPCGYAGLETVDMATLGVTAGWNDVARTFAACLTANLDGSPAAVAQPQAGALTA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBX1_SCHPO
Sequence: MDINPPPSTAPSSPRRSIQRISDAKNKALTFNRRRLGLIKKAHELSVLCDAKVVVMIFDSKNACHVYSSEEPEEQRDALLQKFLNKDFVTVDPLRNINPNIPSDESLHNWRPKDKRIASVTTYSAQPSNNCSSATDSENDFQSFTIKSSTTYHTTPTTASENKKIESITIPDHASVYNDLPLSPTVKHSFVSPVSGDYSDSPLEPSSSSSFSVPPESLNPTLSFQHNDVPQTDNFIPFLTPKRQAYGQSSSRADRSSVRRSQSFKNRRNGKPRISRLHTSHASIDGLTDFIQSPSSGYLDPSSTPITPLDSAINQITPPFLPDNLGQENRGELYSHDNPTSMVYEHPKFDELPNGFIDTHELNILSRSFTASPNQILRESNMVNQDSFTDNPVDATWDALIGTTQIDLDLDYERSSIPSSTIPADQLKDGVPTNSVYRNNMVDHNLYPSLNIERNAP
What is the function of this protein?
Acts as a transcriptional activator with a role in the regulation of mitosis.  Regulates septation and the periodic transcription of cdc15.
What are the official names of this protein?
MADS-box transcription factor 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: GSTO2_CAEEL
Sequence: MSVLSGLNTKVVKNGDPAPAPPASGTIRIYNMRYCPWAQRALIFASLKKIPTEVINIHLDQKPDWFFTKHYKGQVPALEHDEGKKIVIESAVIPEYLDDIYPEPRIIPTDHYEKVQQKLLLDRISGQLSSAFYGVVQAAKISDLLKEKLVELAKAYDTAEELLTGDFYSGTSKPGFVDYLIYPNIQRAFWTSHIIKDFPLKVESFPGPNYPKLSKWYKRLDSIPEVIATSQPTETAVEFFKSWIIGAPNFDYGL
What is the function of this protein?
Exhibits glutathione-dependent thiol transferase activity.  Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid.  Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity).
What are the official names of this protein?
Probable glutathione transferase omega-2, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V) reductase.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Omega family.
Protein: RS2_METBF
Sequence: MAEAKPAPEKEAAAKTESVPVETEGEGPSVKEGSTSLVSIDEYLAAGVHIGTQQKTQDMMRFVYRVRTDGLYVLDIQSTDERIRVAAKLLSHYDPSRILVVSSRQYGQHPARMFSRALSTKSMLGRFIPGLLTNPQIHGFFEPDIVIVTDPAGDAQVLKEASSIGVPIVALCDTNNLTSNVDLVIPTNNKGRKALSLVYWLLAREVSRLNSTPFNYELTDFETPL
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PPO2_HOLDI
Sequence: MSNTAVLNDLVALYDRPTEPMFRVKAKKSFKVPKEYVTDRFKNVAVEISNRFGEDDSETVTIDSVPLPDLADILTLGREENFSLFIPKHRNLSAKLINIFLQAENPKHLLSIACYAHDRVNPYLFIYALSVALIHRKDTKSLKIPNQIQTFPDKYFDSQVFSQGKEEMTVVPQGLRRPIEIPRDYTASDLEEEHRVAYWREDLGINLHHWHWHLVYPTDGGEIVTKKDRRGELFYYSHQQIVARYNFERFCNALKRVERLTDWQGPIKEAYFPKLDSLVAKRAYPARVQDMTMQDLDIPGQNIKVDVDDMIRWRDRIYRAIADGFITATNGSKMNLDDVTGIDILGNIMESSELSPNRQLYGNLHGFGHLMLSYIHDPRSHHLEPFGVIGDFTTAMRDPIFYRWHAFVDDVFQQFNGSLPRYTAEQLDYAGVQITDVNIKTPNAPDNEFRTFWQQSDVDMSRGVDFQDPGSVFVRFTHLNHEPFSYNITVNNTGNGVQEGTCRIFLAPATDERGNPWLFNNQRVMFVEMDRFKVTLRQGQNTITRNSTQSSVTIPFERTFRDLDTNRPAEGSEELDIFNFCGCGWPHHLLVPKGTPDGFKAQLFVMISNYADDKVEQDLSGSCNDAESYCGVRGGKYPDKRPMGYPFNRVARQGADTLQRFLTGNMIVQNCRIVHSDRTVRPRS
What is the function of this protein?
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity).  Catalyzes the oxidation of o-diphenols (N-acetyldopamine, 4-methylcatechol and dopamine) (PubMed:12185078, PubMed:9085271, PubMed:16362048).  Cannot oxidize monophenols and p-phenols (L-tyrosine, tyramine, gentisic acid and hydroquinone) (PubMed:9085271).  Binds to the surface of hemocytes and is involved in hemocyte melanization (By similarity).  Activation of the enzyme in response to bacterial lipopolysaccharides (LPS) suggests it may play a role in innate immunity (PubMed:9839951).
What are the official names of this protein?
Phenoloxidase 2, Prophenoloxidase-II.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in the hemolymph.
Protein: NADE_PHOPR
Sequence: MEQLIRAEMHVLPEIDVDFEIQRRVAFIQKKMKVSGCKSIVLGISGGVDSTTCGRLAQLAVNGLNDESNSSTYQFVAVRLPYGEQHDEHEAQMALSFIKPSHSVSVNIKDGVDGIHASTLFALKGTGLTPEKDAKIDFVKGNVKARARMIAQYEIAGLVGGLVLGTDHSAENITGFYTKFGDGACDLAPLFGLNKRQVRLIASKLGAPDVLVQKVPTADLEELAPQKADEDALLVSYDQIDDFLEGKTVDSEVSERLISIYKMTQHKRQPIPTIYDDE
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: HSLV_PEDPA
Sequence: MPVKFDATTIIAISHNGENAMAGDGQVTMGEKFIMKGTARKVRRIYDGKVIVGFAGSVADAFNLEEKFEKKLSEYSGNLQRASVELAKIWRGDQQLQKLEAMLIVMDEKEMYLVSGSGEVIAPDDGILAIGSGGNFALAAAKALKKHATQVSAKEMAKTAINVAGDIDIFTNHNVIALDFKEED
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGLRA_ASPKW
Sequence: MPSAKPLFCLATLAGAALAAPAPSRATDFNKRSTCTFTDAATASESKTSCSDIVLKDITVPAGETLNLKDLNDGTTVTFEGTTTWEYEEWDGPLLRISGKDITVTQSSDAVLNGNGAKWWDGEGTNGGKTKPKFFYAHDLDDSKISGLYIKNTPVQAISVESDNLVIEDVTIDNSDGDSEGGHNTDGFDISESTYITITGATVKNQDDCVAINSGENIYFSGGTCSGGHGLSIGSVGGRDDNTVKNVTFIDSTVSDSENGVRIKTVYDATGTVEDITYSNIQLSGISDYGIVIEQDYENGDPTGTPSNGVTISDVTLEDITGSVDSDAVEIYILCGDGSCTDWTMSGIDITGGETSSDCENVPSGASCSQ
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.  Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall (By similarity).
What are the official names of this protein?
Probable endopolygalacturonase A, Pectinase A, Polygalacturonase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL5_AERS4
Sequence: MAKLHDYYKSDVVNELAKQFGYKTIMQVPRIEKITLNMGVGEAISDKKLLENAAADMAAISGQKPLITKARKSVAGFKIREGYPIGCKVTLRGERMWEFLERLICISVPRIRDFRGLNAKAFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTSANTDEEGRALLAAFNFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: NTPA_PEA
Sequence: MELLIKLITFLLFSMPAITSSQYLGNNLLTSRKIFLKQEEISSYAVVFDAGSTGSRIHVYHFNQNLDLLHIGKGVEYYNKITPGLSSYANNPEQAAKSLIPLLEQAEDVVPDDLQPKTPVRLGATAGLRLLNGDASEKILQSVRDMLSNRSTFNVQPDAVSIIDGTQEGSYLWVTVNYALGNLGKKYTKTVGVIDLGGGSVQMAYAVSKKTAKNAPKVADGDDPYIKKVVLKGIPYDLYVHSYLHFGREASRAEILKLTPRSPNPCLLAGFNGIYTYSGEEFKATAYTSGANFNKCKNTIRKALKLNYPCPYQNCTFGGIWNGGGGNGQKNLFASSSFFYLPEDTGMVDASTPNFILRPVDIETKAKEACALNFEDAKSTYPFLDKKNVASYVCMDLIYQYVLLVDGFGLDPLQKITSGKEIEYQDAIVEAAWPLGNAVEAISALPKFERLMYFV
What is the function of this protein?
Might be involved in RNA transport out of nuclei.
What are the official names of this protein?
Nucleoside-triphosphatase, NTPase, Nucleoside triphosphate phosphohydrolase, Apyrase.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYL_STRPQ
Sequence: MTFYDHTAIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITVYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTDKNFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVADYKRQASLKSDLARTDLAKEKTGVWTGSYAINPVNGKEIPVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVEEAAFTEDGLHINSGFLDGLDKASAIAKMVEWLEAEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANVTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDKLFSDYAKGFVQLIAPFAPHLGEELWQALTASGESISYVPWPSYDESKLVENDVEIVVQIKGKVKAKLVVAKDLSREELQEVALANEKVQAEIAGKDIIKVIAVPNKLVNIVIK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APEX2_MOUSE
Sequence: MLRVVSWNINGIRSPLQGLACQEPSSCPTALRRVLDELDADIVCLQETKVTRDVLTEPLAIVEGYNSYFSFSRSRSGYSGVATFCKDSATPVAAEEGLSGVFATLNGDIGCYGNMDEFTQEELRVLDSEGRALLTQHKIRTLEGKEKTLTLINVYCPHADPGKPERLTFKMRFYRLLQMRAEALLAAGSHVIILGDLNTAHRPIDHCDASSLECFEEDPGRKWMDGLLSNPGDEAGPHIGLFMDSYRYLHPKQQRAFTCWSVVSGARHLNYGSRLDYVLGDRALVIDTFQASFLLPEVMGSDHCPVGAVLNVSCVPAKQCPALCTRFLPEFAGTQLKILRFLVPLEQEPVREQQVLQPSHQIQAQRQPRKACMHSTRLRKSQGGPKRKQKNLMSYFQPSSSLSQTSGVELPTLPLVGPLTTPKTAEEVATATVLEEKNKVPESKDEKGERTAFWKSMLSGPSPMPLCGGHREPCVMRTVKKTGPNFGRQFYMCARPRGPPSDPSSRCNFFLWSRPS
What is the function of this protein?
Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.  Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.  Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities.  Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially.  Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents.  In the nucleus functions in the PCNA-dependent BER pathway.  Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes.  Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
What are the official names of this protein?
DNA-(apurinic or apyrimidinic site) endonuclease 2, APEX nuclease 2, Apurinic-apyrimidinic endonuclease 2, AP endonuclease 2.
What is the protein family that this protein belongs to?
Belongs to the DNA repair enzymes AP/ExoA family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Mitochondrion. Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Protein: ADLO2_ARATH
Sequence: MSRRVRQRVEDNGKYKVDSPSYTVIGVEDLAPKVQQYVNWTSLPYDTVFHLFTRLNYRDRASLASTCRTWRSLGASSFLWSSLDLRAHKFDLSMAASLATRCVDLQKIRFRGVDSADAIIHLKARSLLEISGDYCRKITDATLSMIAARHEALESLQLGPDFCERITSDAIRVIAFCCPKLKKLRVSGMRDVSSEAIESLAKHCPQLSDLGFLDCLNINEEALGKVVSLRYLSVAGTSNIKWKVALENWEKLPKLIGLDVSRTTIDHIAVSRLLKSSQSLKVLCALNCPYLEEDKSYSSNRFKGKVLLAVFTDTFDELASIFADNSKKPKNIFSYWRDLIRKDKSIDEIMLWIEWIISHTLLRIAESSNSQGLNDFWLNQGATLLLSLMQSAQEDVQERAATGLATFIVVDDENASIDCGRAEAVMRDGGIRLLLELAKSWREGLQSEAAKAIANLSVNAKVAKAVAEEGGISVLADLAKSMNRLVAEEAAGGLWNLSVGEEHKNAIAQAGGVNALVDLIFRWPHGCDGVLERAAGALANLAADDKCSMEVARAGGVHALVMLARNCKYEGAQEQAARALANLAAHGDSNGNNAAVGQEAGALEALVQLTQSPHEGVKQEAAGALWNLAFDDKNRESIAAFGGVEALVALAKSSSNASTGLQERVAGALWGLSVSEANSIAIGHEGGIPPLIALVRSEAEDVHETAAGALWNLSFNPGNALRIVEEGGVVALVQLCSSSVSKMARFMAALALAYMFDGRMDEYAMIGTSLESTSKSVTLNGARTMALDQIKAFIKTFMEHQIFSTGALSSAPSMLAQVSERARIPEAGHLRCSGSEIGRFVTMLRNPCLVLRACAAFALLQFTIPESRHAMHHASLMQNAGEARGLRSAAAAASMPREAKIFMKIVLRNLEHQQAESPEGMKVSYNRI
What is the function of this protein?
Promotes lateral root initiation and development, independently of auxin (IAA) and abscisis acid (ABA).
What are the official names of this protein?
Protein ARABIDILLO 2.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPH_CYACA
Sequence: MDPIISAASVIAAGLAVGLAAIGPGIGQGSAAANAVEGLARQPEAEGKIRGTLLLSLAFMESLTIYGLVVALSLLFANPFIK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NTCP2_MOUSE
Sequence: MDNSSVCPPNATVCEGDSCVVPESNFNAILNTVMSTVLTILLAMVMFSMGCNVEVHKFLGHIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGMMPLCLFVYTKMWVDSGTIVIPYDSIGISLVALVIPVSFGMFVNHKWPQKAKIILKIGSITGVILIVLIAVIGGILYQSAWIIEPKLWIIGTIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVFAAVILGIYVTYRKCYGKNDAEFLEKTDNEMDSRPSFDETNKGFQPDEK
What is the function of this protein?
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:10101301).  Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:10101301).  Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids.  Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity).
What are the official names of this protein?
Ileal sodium/bile acid cotransporter, Apical sodium-dependent bile acid transporter, ASBT, Ileal Na(+)/bile acid cotransporter, Ileal sodium-dependent bile acid transporter, IBAT, ISBT, Na(+)-dependent ileal bile acid transporter, Sodium/taurocholate cotransporting polypeptide, ileal, Solute carrier family 10 member 2.
What is the protein family that this protein belongs to?
Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CARDI_NOVAD
Sequence: MVTKGVVVVSSFRRSRQDANRPHAFLTGIHAPVKEERTIEDLAVTGTIPAELSGRYVRIGPNPFRADPRGHHWFVGDGMVHGVCMKGGKALWYRNRYVRSRNLQDAGGPAAAPGPRRSTFDTVNTNVIQHAGRTFALVEAGSFPVELTHDLESFAYSDLGGTLKGPFSAHPHLDPLTGELHAVTYDGQTLDTVWHVVVDREGRVRREEPVPVAHGPSIHDCAITAKYVLILDLPVTFSMAALVGGARFPYRWNPAHRARVGLLPREGTAADVIWCDVDAAYVFHVANAFDNPDGTVTVDLAAYETMFAHGPDGPNGKSLGMERWTVDPAARKVARKTLDAAPQEFHRPDERFFGQPYRFAWSMGLPAENAEDFLGHAPIYGYDLATGQRSAHDFGPGKIPGEFVFIPRRADAEEGDGWLMGYVIDLASETTDLAILDARNLAAPPLALIHIPCRIPPGFHGNWLPDAAD
What is the function of this protein?
Catalyzes the conversion of 8'-apo-beta-carotenal to 13-apo-beta-carotenone and C12-dialdehyde.  Has also weak activity with 4'-apo-beta-carotenal and gamma-carotene.
What are the official names of this protein?
8'-apo-carotenoid 13,14-cleaving dioxygenase, NACOX1.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.