PharMolix/UniProtQA huggingface dataset:
Protein: DPO3A_DEIRA
Sequence: MTVSDAPTPHIHLPDGSCCQPKKFAHLHQHTQYSLLDGAAKLKDLLKWAKEVTPEGQTPALAMTDHGNMHGAVHFYNYAMGMEVKPIIGYEAYVVPGFGTRRDRSRAQDGEKGIFHLTLLARDFEGYQNLCRLSSRGYTEGYYYKPRIDHELLQEHHKGIIAFSGCLGSEVQQLLMQGREDDARARLLWYRELFGDNYFIEIQDHGLPEQKKNNPILKAWAQELGIGMVATNDGHYVKKSDATAHETLLAIQTKATLADENRFKFPCDEFYVKNLEEMQRALPVSEWGEEPFDNTAHIAELCNVELPVGKKRQYQMPQLPIPEGRSMAEELRVQTYAGAVKRYPAHLTEGLLRDYAARSLAELGEADAARVLKRTGGCDSASCDLDTLYTLLAFLGSEWEARGKEAGEKYTPYPALEKMEQDGESGTLPAYAHADCRAARRQDSDTSIELDPDTDDEETTRSHHRYALKLLRRAEYELSVINNMGFPDYFLIVADYINWAKDHDISVGPGRGSGAGSLVAYAIRITNLDPLEFELLFERFLNPDRISMPDFDIDFNDARRTEVIGYVQEKYGTDKVAQIATFGTMASKACLKDVARVMGLEYAKVDKVSKLIPIKFGKSYSLEQAREAVPDIQQMLAEDAQLLEAYEFAQKLEGLTRHASVHAAGVVIGREELTNLVPVMRDTSGEGQVCQYDMKSVEDIGLIKMDFLGLRTLSFLDEAKRILRESGTDFEEKYGDFDHIPFDDEKTYELMSRGDTKGVFQLEGAGIADASRRLKPRRLADIIALSALYRPGPMENIPTYVRRHHGIEEVDYDKDGFPNSKQWLEKILQETYGIPVYQEQIMQIASEVAGYSLGGADLLRRAMGKKDAEEMKRQRQLFVVGAKEKGVPEDEGNKLFDMLDAFANYGFNKSHSAAYGVITYQTAWLKANYPVQFMAALLTVERRDSDKVAEYVSDARKMDLHVLPPDINRSSSDFAVAGEEILFGLYAIKGLGESAVLRILEEREKAGAFKSLADFCSRLGNKVCNRKALESLIKSGAFDAFGERHQLIESLEDALEDAAGTAEINARAQSGMSMMFGMEEVKKERPLRSSIAPYSDLERLAIEKEALGLYISGHPLEQHEGLREAASCRVSDLDAWFALQNVAPGKRQKAVLAGMIEGVVKKPTKSGGMMARFILADESGQMELVAFSRAYDRIEPKLVNDTPALVIVELEAEDGGLRAIAEEIVSIEQLSEVPKVMYVTIDLETASPDALGDFQSVLDEYAGSMPTYLRLETPEQFVVYQLDHGMGSPEAIRALNQTFAWADAHLAYDQQTILGRFAPKPPAWMNRQQGGGMRA
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative DNA synthesis in bacteria as well as the bulk of DNA synthesis/repair after ionizing radiation (IR) (PubMed:19303848).  The alpha chain is the catalytic subunit (PubMed:19303848).  Following severe irradiation (7 kGy of gamma irradiation) genomic DNA is fragmented.  DNA is progressively degraded for the first 1. 5 hours after IR, in a step promoted by RecA and counterbalanced by DNA Pol I and Pol III, followed by massive DNA synthesis and genome reassembly in the next hour.  Optimal priming of DNA synthesis requires both RecA and RadA, Pol III initiates DNA synthesis while both Pol I and Pol III are required for its contination (PubMed:19303848).  This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha, Pol III catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF179_IIV6
Sequence: MTCLDPKTIWPNEAVPNVRYRDFSKMVLFTAGDEDQFERKRSYKNGTNPDKKVSLDGNIWTNLFVPNEGLETEFWNGYNLNASSTINTFDYMFNKFKKGIFVKIVDNKVVTFLPFSKHGYKNDWGDLMKYDPSKYKSMIDFMRHVSNQTAIANNKNYKFKPDQVSRYTNQWYSNNCLIRYEHPLSEGDTNVVTLRHMFDELCATREVPDIELFINRRDFPLLTKNGTEPYYNIFGKDHSLDSKSLKLISEGMCPILSMCTSDMYADIVIPTHEDWARVASTEGVKTHVGDKENNENSLPKKITFPPQCKDYSKDNFNTPWEKRIPTAVFRGGSTGCGVSSDTNLETFNQRLVAAKISYNSKPDKYNVPLITAGITKWNLRPRKILNEKYLQTINIEKEAPKVSPLTPEEQSKYKYIINIDGHVSAFRLSLEMSMGCCILLVKSKIPNETFGWKMWFSHLLKPYIHYVPVKSDLSDLIEKIQWCRDNDEKCKEISQEALKFYQTYLSRESILDYMQNLMVKLKLSFPTNEIVYGTDPLFIQNSVQSKYLFNMMNNSINPIFPFLTPYLIPKPIPIYNILGTSLRGSYGWSKGYSMFLKHMFKPTIPKEKDNLKENANQNERKLNEKLNEESRVFTENQQENDWEMKRSTINLKGVFEKRLFENKKSTVDLYSISGSNVVKKSTSDAQGMIEHINEAFISDTCINNLLKIIPNFAWSFAFEKSLNENGVEQCTLLNEYIEGETFSTSIKNKMSYLGFSSGKPFKNVLEVLFQIILSIQFAQEQCGFIHNDLTPWNIIIQTLKEPITIQYPLFSGIYKIITKHVPVIIDYGKSHVATSPYGDFCFNELSVGNVIHYGVVNMFNMIECQDVFSIILYSCLDMLTVNGTKFSQRENDETEYDEQSIIKMLNFFSPTELKTRKEALSFIYQYKKYENLIKAHETINLEKSPIEFIKYFTSIFKKEKVVYGLSRLDSKRTGLIMDFNNPKQIFDEAFAQNIQEVYISFLNVPQNLYKCTLPQPKTKIELYMVAQLLIKCLKDTLKDYRIFAEKSSLRKESFHNDIIKFENAINFITTFYSKEISKHGNDSWVIPELCENNQIEISRNYFRTTSDTLNYSIKPCTDLTFFKKTILNILNWTDDEGLFEIKAEDRVEISTQLKFVLESTFKDKKISANNNTYIVYKKYCNKKYCI
What are the official names of this protein?
Uncharacterized protein 179R.
Protein: MDTA_YERPS
Sequence: MKSQSKRTSRLFVFVGVVVAIIIAVLSWRYFGTGSDNNTSGAQQSARGQDTSHGGRRNTPLAPVQAATATEQEVPRYLTGLGTVIAANTVTVTSRVDGELMALHFTEGQQVKAGDLLAEIDPRPYEVQLTQAQGQLAKDQATLDNARRDLARYQKLSKTGLISQQELDTQSSLVRQSEGSVKADQGAIDSAKLQLTYSRITAPISGRVGLKQVDVGNYITSGTATPIVVITQTHPVDVVFTLPESDIPAIMQAQKNAEKTHAIVPVEAWDRTNKQMLAQGYLLSIDNQIDTTTGTIKLKARFNNEDDVLFPNQFVNARIKVDLLQNAVVVPTAAVQMGSEGNFVWTLDDANRVSKHLVTTGIQDSQQVVIDAGLNAGQRVVTDGIDRLTEGVQVEVVTPRSANTDTNPASAEKAAAEAEGSTPHQGRGRPANAPARSTTAAEKS
What are the official names of this protein?
Multidrug resistance protein MdtA, Multidrug transporter MdtA.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GHSR_PIG
Sequence: MWNATPSEEPGPNLTLPDLGWDAPPENDSLVEELLPLFPTPLLAGVTATCVALFVVGIAGNLLTMLVVSRFREMRTTTNLYLSSMAFSDLLIFLCMPLDLFRLWQYRPWNLGNLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHDNGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRKRGEAAVGSSLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSLEPGSVEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFEPFSQRKLSTLKDESSRAWTESSINT
What is the function of this protein?
Receptor for ghrelin, coupled to G-alpha-11 proteins.  Stimulates growth hormone secretion.  Binds also other growth hormone releasing peptides (GHRP) (e. g.  Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e. g.  L-692,429, MK-0677, adenosine).
What are the official names of this protein?
Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, GHRP, Ghrelin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NSP4_ROTHT
Sequence: MDKLADLNYTLSVITSMNDTLHSIIEDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKASKCSYKVIKYCVVTIINTLLKLAGYKEQVTTKDEIEQQMDRIVKEMRRQLEMIDKLTTREIEQIELLKRIHDNLITRPVNVIDMSMEFNQKNIKTLDEWESRKNPYEPSEVTASM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: PROA_STRPG
Sequence: MTDMRRLGQRAKQASLLIAPLSTQIKNRFLSTLAKALVDDTQTLLAANQKDLANAKEHGISDIMMDRLRLTSERIKAIAQGVQQVADLADPIGQVIKGYTNLDGLKILQKRVPLGVIAMIFESRPNVSVDAFSLAFKTNNAIILRGGKDALHSNKALVKLIRQSLEKSGITPDAVQLVEDPSHAVAEELMQATDYVDVLIPRGGAKLIQTVKEKAKVPVIETGVGNVHIYVDAQADLDMATNIVINAKTKRPSVCNAAEGLVIHEAVAARFIPMLEKAINQVQPVEWRADDKALPLFEQAVPAKAEDFETEFLDYIMSVKVVSSLEEAISWINQHTSHHSEAIITRDIKAAETFQDLVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMGLEALTSTKFYINGDGHIRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_PSEF5
Sequence: MQTLKVDLGERSYPIHIGEGLLDQPELLVPHIAGRQVAIISNETVAPLYLERLTRSLGQFSVISVVLPDGEAYKNWETLQLIFDGLLTARHDRRTTIIALGGGVIGDMAGFAAACYQRGVDFIQIPTTLLSQVDSSVGGKTGINHPLGKNMVGAFYQPNVVLIDTTSLNTLPSRELSAGLAEVIKYGLICDEPFLTWLEENVDRLRALDQQALTYAIERSCAAKAAVVGADERESGVRATLNLGHTFGHAIETHMGYGVWLHGEAVAAGTVMALEMSARLGWITSQERDRGIRLFQRAGLPVIPPEEMSEADFLEHMAIDKKVIDGRLRLVLLRRMGEAVVTDDYPKEVLQATLGADYRALAQLKG
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B4GT6_MOUSE
Sequence: MSALKRMMRVSNRSLIAFIFFFSLSTSCLYFIYVAPGIANTYLFMVQARGIMLRENVKTIGHMIRLYTNKNTTLNGTDYPEGNNTSDYLVQTTTYLPQNFTYLPHLPCPEKLPYMRGFLSVNVSEISFDEVHQLFSKDSEIGPGGHWRPKDCKPRWKVAVLIPFRNRHEHLPIFFLHLIPMLQKQRLEFAFYVIEQTGTQPFNRAMLFNVGFKEAMKDRAWDCVIFHDVDHLPENDRNYYGCGEMPRHFAAKLDKYMYILPYKEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVHYAGYNVTRPEGDLGKYISIPHHHRGEVQFLGRYKLLRYSKERQYIDGLNNLLYTPKILVDRLYTNISVNLMPELAPIEDY
What is the function of this protein?
Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:23882130, PubMed:30114188).  LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (PubMed:30114188).
What are the official names of this protein?
Beta-1,4-galactosyltransferase 6, Beta-1,4-GalTase 6, Beta4Gal-T6, b4Gal-T6, Glucosylceramide beta-1,4-galactosyltransferase, Lactosylceramide synthase, LacCer synthase, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6, UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 7 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
Protein: SESQ2_HUMAN
Sequence: MKLNERSVAHYALSDSPADHMGFLRTWGGPGTPPTPSGTGRRCWFVLKGNLLFSFESREGRAPLSLVVLEGCTVELAEAPVPEEFAFAICFDAPGVRPHLLAAEGPAAQEAWVKVLSRASFGYMRLVVRELESQLQDARQSLALQRRSSWKSVASRCKPQAPNHRAAGLENGHCLSKDSSPVGLVEEAGSRSAGWGLAEWELQGPASLLLGKGQSPVSPETSCFSTLHDWYGQEIVELRQCWQKRAQGSHSKCEEQDRP
What is the function of this protein?
Plays a role in endocytic trafficking.  Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
What are the official names of this protein?
Sesquipedalian-2, Ses2, 27 kDa inositol polyphosphate phosphatase interacting protein B, IPIP27B, PH domain-containing endocytic trafficking adaptor 2.
What is the protein family that this protein belongs to?
Belongs to the sesquipedalian family.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.
Protein: MTC9_CITFR
Sequence: MPSKKSSSPLSVEKLHRSEPLELNGATLFEGDALSVLRRLPSGSVRCIVTSPPYWGLRDYGIDEQIGLESSMTQFLNRLVTIFSEAKRVLTDDGTLWVNIGDGYTSGNRGYRAPDKKNPARAMAVRPDTPEGLKPKDLIGIPWRLAFALQEDGWYLRSDIVWNKPNAMPESVKDRPTRSHEFLFMLTKSEKYYYDWEAVREEKDSGGFRNRRTVWNVNTKPFAGAHFATFPTELIRPCILASTKPGDYVLDPFFGSGTVGVVCQQEDRQYVGIELNPEYVDIAVNRLQGEDTNVIRIAAA
What is the function of this protein?
A beta subtype methylase, recognizes the double-stranded sequence 5'-CCCGGG-3', methylates C-2 on both strands, and protects the DNA from cleavage by the Cfr9I endonuclease.
What are the official names of this protein?
Type II methyltransferase M.Cfr9I, M.Cfr9I, Modification methylase Cfr9I, N(4)- cytosine-specific methyltransferase Cfr9I.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.
Protein: AEP1_ZYGRC
Sequence: MPTKPRHIPRNFFLDQKSRYQKNGLTPLPHQIIHPFYTPTRAAELSACSKEVRGKLLEGLKVVPALVTDWKGKPLLRNRFIKFDTVKGVNVWLQGYASRRKEAEGVIYRTLEGQPEKLITPSKLHRSNVPLVDKVTELFGSERTKHLNSAALDSIVDELVNDREKNLFCEDVYIYLLQHHVNSEGKLIAIIESIKSHMEADIDQLKVAETLILQLVLSMQRNRLPVTKELVNAYHQLIDAVNQKFYTNACELQFDPLVTQCILEFHIMSGDLNHSKKLLSHLILNGWALREDLSVKYLQLVESKVRDEDIDTRTLKRFAYISDFRPLLQRAQTPLFFAALVPYCRHFGELYSLLTVITEKVHNTREVFDVTLLSMIEATTHMGKNNRYKSANLYELHRTVLPYYDNNLPAKFVKAFALQFAKFNNWSAIAGFFKQYPSYFTPNSIASLLSASQEGVTDSTNYPGGVVQMRKIFIWEYVLPLYSKMSLRARSSISATFDTPKLFTEAIKQELKLVSAGQADVMNELIAMGYESNLLRFIPATTWEDIFRVPHLVAALKPFSQEIESLSGKAAGATESSQ
What is the function of this protein?
Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.
What are the official names of this protein?
ATPase expression protein 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AEP1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: S115A_PONAB
Sequence: MTDTPVEESLFQIIHCFHQYAARQGDMETLSLQELQALLMDNMPRFMDSLGRKEPYYITELFQAADKNKDNQICFDEFLYILGKLVKDYHLQYHRQLCARYCAQHSLY
What are the official names of this protein?
Protein S100-A15A, S100 calcium-binding protein A15A.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
Protein: QUEC_SALSV
Sequence: MKRAVVVFSGGQDSTTCLAQARHQYDEVHCVTFDYGQRHRAEIDVARALALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPNADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVNLGMAKDIRFETPLMWIDKAETWALADYWGQLELVREETLTCYNGIKGDGCGHCAACNLRANGLNHYLSNKAAVMAAMKQKTGLR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RS19_FRAAA
Sequence: MPRSLKKGPFVDDHLLKKVDVQNSKGTKHVIKTWSRRSTVIPDMLGHTIAVHDGRKHVPVFITEGMVGHKLGEFAPTRTFRGHVKEDRRSRRG
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: UVRB_HAEDU
Sequence: MSKPGKPFILNSPFAPSGDQPSAIKKLTEGLQDGLAHQTLLGVTGSGKTFTIANVIAQLNRPAMLLAPNKTLAAQLYAEMKAFFPENAVEYFVSYYDYYQPEAYVPASDTFIEKDASINEQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDVNAYMQMMLHLQVGAIINQRDILARLAELQYTRNDQAFQRSTFRVRGEVIDIFPAESDEIALRIELFDDEIDNLSLFDPLTGHSFGKIPRYTIYPKTHYVTPRERILTAIDQIKNELTGRQDYFIKEHKLLEEQRITQRTQFDIEMINELGYCSGIENYSRYLSGRQEGEPPPTLFDYMPADGLLIIDESHVTVPQIGGMYRGDRARKETLVQYGFRLPSALDNRPLKFEEFERLSPQTIYVSATPGNYELEKSNGDIIDQVVRPTGLLDPIIEVRPVASQVDDVLSEIQQRVALDERVLITTLTKKMAEDLTDYLDEHGVRVRYLHSDIDTVERVEIIHDLRIGMFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSESSLIQTIGRAARNLNGKAILYADRITHSMQKAITETERRREKQQKYNQEHNIIPQALNKKVRELLDIGQTDKQKKGKQAVKIAEQSASYTPNAPKSRQALEKELKQLTQQMQKLAKDLEFEKAAAVRDKIGQLKMALLEV
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDF4_CHICK
Sequence: MTKTYTKAKEMAELVGTQGWMDDALSSKDELKAENGRPGPFGLVAGLNEEHDSIEEEEEEEDDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKSFVEMLCKGLSQPTSNLVAGCLQLGPQTLFLEKHEEKTPGCESAISSHSFTYQSPGLPSPPYGSMETHLLHLKPPAFKSLVDASFGNPPDCTTPPYEGPLTPPLSISGNFSLKQDGSPDLDKPYAFMAHYPSVSLAGAHGHPTHFQNAVPRYEIPIDMSYESYPHHVAGPQLNAIFNE
What is the function of this protein?
Probably acts as a transcriptional activator.  Mediates neuronal differentiation.  Required for the regulation of amacrine cell fate specification in the retina (By similarity).
What are the official names of this protein?
Neurogenic differentiation factor 4, NeuroD4, NeuroM.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y614_MYCPN
Sequence: MPFLKYWKLMGFSLTPLLLSSATINSHVIDSSFYLTKNLVESENQSPIQFNQLSRIILVQLEFDPDSIVDNTSITFNNRTLGQKALLKLRFKREFTLAIQEITELNQLVDQAIDKNTVLQNFLTLKNVERKQQWERLSYLYKLLNFDFRDPQELSLVRDLPRLLKTIFESASINFQVRMGGQLRKITLVKNNNNVFNLGQFEQFLNLDQISINLFEVEFLSFDFISDQYPSWTAKNLPVFSLFESAKNKPTIQKTNQGIQYRLRFRSNYNEQYLNKYRFSIPVVNNGKEFSVLDIQDKELTEEQKNQIAFVIKNGFFISGWYGINCCLKFNQIS
What are the official names of this protein?
Uncharacterized protein MPN_614.
What is the protein family that this protein belongs to?
Belongs to the MG414/MG415 family.
Protein: TRMFO_STAAE
Sequence: MTQTVNVIGAGLAGSEAAYQLAERGIKVNLIEMRPVKQTPAHHTDKFAELVCSNSLRGNALTNGVGVLKEEMRRLNSIIIEAADKARVPAGGALAVDRHDFSGYITETLKNHENITVINEEINAIPDGYTIIATGPLTTETLAQEIVDITGKDQLYFYDAAAPIIEKESIDMDKVYLKSRYDKGEAAYLNCPMTEDEFNRFYDAVLEAEVAPVNSFEKEKYFEGCMPFEVMAERGRKTLLFGPMKPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGAQKEVIKLIPGLENVDIVRYGVMHRNTFINSPDVLNEKYELISQPNIQFAGQMTGVEGYVESAASGLVAGINLAHKILGKGEVVFPRETMIGSMAYYISHAKNNKNFQPMNANFGLLPSLETRIKDKKERYEAQANRALDYLENFKKTL
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_PARDA
Sequence: MGAYKYMQELWRKKQSDVMRFLLRVRCWQYRQLSSLHRTPKPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQIKFARSLQSTAEERAGRHCGGLRVLSSYWVGEDSTYKFFEVILVDIFHKAIRRNPDTQWITKAVHKHREMRGLTSAGKKSRGLGKGHKFHLTIGGSRRAAWRRRNTLQLHRYR
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTL_SALAR
Sequence: MKRFLLCSFTLILLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISALNMLIGILIGCSIVSMLLILSVAPNRSISEHEEIHNQSRP
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DRP2_HUMAN
Sequence: MQPMVMQGCPYTLPRCHDWQAADQFHHSSSLRSTCPHPQVRAAVTSPAPPQDGAGVPCLSLKLLNGSVGASGPLEPPAMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALEQINVRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQVPWERAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQASEHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKTGIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGVLLHEAIQVPRQLGEVAAFGGSNVEPSVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPIKGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFRSKHYFSKHPQRGYLPVQSVLEADYSETPASSPMWPHADTHSRIEHFASRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAPCSVATESKGELQKILAHLEDENRILQGELRRLKWQHEEAAEAPSLADGSTEAATDHRNEELLAEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPTESDGSGSAGSSLASSPQQSEGSHPREKGQTTPDTEAADDVGSKSQDVSLCLEDIMEKLRHAFPSVRSSDVTANTLLAS
What is the function of this protein?
Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells.  Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane.  Possibly involved in membrane-cytoskeleton interactions of the central nervous system.
What are the official names of this protein?
Dystrophin-related protein 2, DRP-2.
What are the subcellular locations of this protein?
Postsynaptic density. Cell projection, dendrite. Perikaryon. Cell membrane; Peripheral membrane protein. Note=Detected in Schwann cells at periaxonal myelin membranes.
Protein: RT25_CAEEL
Sequence: MPFMHGSMPLRRTFFYLQQGKVKLRDNVNVFSMGFHKNPTPEQSGARDFVYWNWAQLQYHNPKVQLVKHADKVVTPFARAYLNDGREVLFDLDGMKREEIEKLLAKTLGKTELVERREHLESIAKLNPADFGSKNERQCMCEVQGQHPCTGLLRAPQCVTGKYRWNHNLI
What are the official names of this protein?
Probable 28S ribosomal protein S25, mitochondrial, MRP-S25, S25mt.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS25 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: IF2_CHRSD
Sequence: MSDMTVKDFASKVGRDVSRLLEQMQEAGLPHKTEGDAVSEEDKQRLLEHLTRSHGGDSGATKNRVTLTRNTKSRIRSGDGRGKAIDVQVRKKRTYVKREPEPAEEKAAEETGPRQLVGDMASANQAKADEAAKAEQAAAEQAAKAKAEEEAAAAAASKAAESEPVAEAPGAPQPEEPETASEPFVEAPPKEPRTPNRRGQNHQKKDTGRGRKRDDDEERRERGERRRGNAKKTKRSERRGSRRGGGRDNQHGFQKPTQPIVREVAIPESISVADLADKMSIKANEVIKAMFTMGAAVTINQTIDQDTAAIVVEEMGHKPKLVKDDALETEVLEGISYEGEEITRAPVVTVMGHVDHGKTSLLDYIRRTKVATGEAGGITQHIGAYHVEHESGDITFLDTPGHAAFTAMRARGAQATDVVILVVAADDGVMPQTVEAVEHAKAAGVPLVVAVNKIDKEGADPDRVKNELSQYGVISEAWGGDTQFVHVSAKSGEGIDALLEAILLVSEVLELKAVPEAPAKGVVVESQLDKGRGPVATVLVQNGTLKRGDIVLAGLHYGRVRALVNELGKRVEEVGPAMPVEIQGLDGTPEAGDEFIVVADEKKAREVANFRQGKYREVRLARQQKAKLENMFSQMGQDEVAKVNIVLKADVQGSLEAIRGALEELSTDEVKVAVVSSGVGGITGTDANLAVASEAILVGFNVRADVSAREIVEREGLDLRYYSVIYQLIDEVKQAMSGMLAPEWKEEIVGVAEVRDVFKAPKIGAVAGCMVVEGTVYRHKRIRVLRENVVIYEGELESLRRYKDDIGEVRSGMECGIGVKNYNDVQVGDKIEVFDQVKVERSL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMLN_PUNGR
Sequence: GSSFCDSKCAVRCSKAGVQD
What are the official names of this protein?
Pommaclein.
What is the protein family that this protein belongs to?
Belongs to the GASA family.