PharMolix/UniProtQA huggingface dataset:
Protein: DIS3_SCHPO
Sequence: MSTVSGLKRPQSSEKNHRDRVFVRATRGKVQKVVREQYLRNDIPCQSRACPLCRSKLPKDSRGNVLEPILSEKPMFLEKFGHHYLIPDSNIFYHCIDALEHPNNFFDVIILQTVFSEISSKSIPLYNRMKRLCQEKTKRFTPFSNEFFVDTFVERLDDESANDRNDRAIRNAASWFASHLASLGIKIVLLTDDRENARLAAEQGIQVSTLKDYVQYLPDSEILLDMVSAIADAIASKEQVESGTKNVYELHWSMSRLLACIKNGEVHKGLINISTYNYLEGSVVVPGYNKPVLVSGRENLNRAVQGDIVCIQILPQDQWKTEAEEIADDDEDVVVSTAAEPDSARINDLELITKRNAHPTAKVVGILKRNWRPYVGHVDNATIAQSKGGSQQTVLLTPMDRRVPKIRFRTRQAPRLVGRRIVVAIDLWDASSRYPEGHFVRDLGEMETKEAETEALLLEYDVQHRPFPKAVLDCLPEEGHNWKVPADKTHPLWKNRKDFRDKLICSIDPPGCQDIDDALHACVLPNGNYEVGVHIADVTHFVKPNTSMDSEAASRGTTVYLVDKRIDMLPMLLGTDLCSLRPYVERFAFSCIWEMDENANIIKVHFTKSVIASKEAFSYADAQARIDDQKMQDPLTQGMRVLLKLSKILKQKRMDEGALNLASPEVRIQTDNETSDPMDVEIKQLLETNSLVEEFMLLANISVAQKIYDAFPQTAVLRRHAAPPLTNFDSLQDILRVCKGMHLKCDTSKSLAKSLDECVDPKEPYFNTLLRILTTRCMLSAEYFCSGTFAPPDFRHYGLASPIYTHFTSPIRRYADVLAHRQLAAAIDYETINPSLSDKSRLIEICNGINYRHRMAQMAGRASIEYYVGQALKGGVAEEDAYVIKVFKNGFVVFIARFGLEGIVYTKSLSSVLEPNVEYVEDEYKLNIEIRDQPKPQTVQIQMFQQVRVRVTTVRDEHSGKQKVQITLVY
What is the function of this protein?
Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  DIS3 has both 3'-5' exonuclease and endonuclease activities.  The exonuclease activity of DIS3 is down-regulated upon association with Exo-9 possibly involving a conformational change in the catalytic domain and threading of the RNA substrate through the complex central channel.  Structured substrates can be degraded if they have a 3' single-stranded extension sufficiently long (such as 35 nt poly(A)) to span the proposed complex inner RNA-binding path and to reach the exonuclease site provided by dis3 (By similarity).  Implicated in mitotic control.  Essential for cell division and spore germination.  May be involved in regulating protein dephosphorylation during mitosis.
What are the official names of this protein?
Exosome complex exonuclease dis3, Chromosome disjunction protein 3, Mitotic control protein dis3, Ribosomal RNA-processing protein 44.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Abundant in the nucleus (PubMed:1944266).
Protein: TRAG_SINFN
Sequence: MTVNRIALVVAPVVLMVLTVIGMSGIEQCLSTFGKTDAARLALGRIGIAFPYVTAAAIAVIFLFASAGSAIIKLAGWGALAGSAATMLIATMREASRLAAFAAQVPAGKSIASYLDHATLIGATAALMSGCFSLRVALIGNAAFARAEPRRIRGKRALHGEADWMNMQDAARLFSDAGGVVIGERYRVDKDSTAARSFRADDPETWGAGGKSPLLCFDGSFGSSHGIVFAGSGGFKTTSVTIPTALKWGGALVVLDPSNEVAPMVYEHRKAAARFIRILDPKEPETGFNALDWIGRFGGTKEEDIASVASWIMSDSGGMRGVRDDFFRASALQLLTALIADVCLSGHTDKENQTLRQVRANLAEPEPKLRERLQSIYDNSNSDFVKENVAAYVNMTPETFSGVYANAVKETHWLSYPNYAALVSGSTFSTDALAAGETDVFINIDLKTLETHAGLARVIIGSFLNAIYNRDGEVKGRALFFLDEVARLGYMRILETARDAGRKYGIMLTMIYQSIGQMRETYGGRDAASKWFESASWISFAAINDPETADYISRRCGMTTVEIDQVSRSFQTKGSSRTRSKQLAARPLIQPHEVLRMRADEQIVFTAGNAPLRCGRAIWFRREDMKACGGEPVSQGRKDV
What are the official names of this protein?
Probable conjugal transfer protein TraG.
What is the protein family that this protein belongs to?
Belongs to the VirD4/TraG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRC_STRP1
Sequence: MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVLKEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVVAFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKTVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPFIGNKLKGVVKYTIADGEVVYPN
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: CAS2_MYCTO
Sequence: MPTRSREEYFNLPLKVDESSGTIGKMFVLVIYDISDNRRRASLAKILAGFGYRVQESAFEAMLTKGQLAKLVARIDRFAIDCDNIRIYKIRGVAAVTFYGRGRLVSAEEFVFF
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).  The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (By similarity).
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: IFNB_HORSE
Sequence: MTYRWILPMALLLCFSTTALSVNYDLLRSQLRSSNSACLMLLRQLNGAPQRCPEDTMNFQVPEEIEQAQQFQKEDAALVIYEMLQHTWRIFRRNFASTGWNETIVKNLLVEVHLQMDRLETNLEEIMEEESSTWGNTTILRLKKYYGRISQYLKAKKYSHCAWTVVQAEMLRNLAFLNGLTDYLQN
What is the function of this protein?
Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli.  Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity).  Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.  Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor.  Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss.  IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).
What are the official names of this protein?
Interferon beta, IFN-beta.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: TIG_CLOBH
Sequence: MNVKVENIEKNVVKLEITVDSEKFNEAVKKSFKKNAKRFNVPGFRKGKAPLNIIKKYYGEGVLFEDAINFCCEDTYPKAIEENNIKPVDYPQIDVVQIGEGKDFIYTAEVTTVPEVKLGEYKGVEVKKVSYEVEDEAVENELKSMQEKNARVSLKEEGEIEKGNIAIIDFKGYVDGKAFEGGEAKDYEIEIGSGTFIGDFEDQLVGLKKDESKEVNVSFPEEYGREDLNGKPATFEVTIKDIKVKELPALDDEFAKEVSEFDTLEELKSDIKDRMKKELSEKAKAEYEEAVVEAVGANAEIEIPKVMIEKEIENMVRDLEMRLKYQGLDLKSYYEFTNSSEEKVKEYMRETAEKRVKTDLIMQEIAKVEDIKATEEELKEKAMEVAKQYGQKDVEKTAELIANAQKAYLEIDIVNGKVLDLLVESSKEIA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: SYS_SULNB
Sequence: MIDLKYLQNNFNEVSMKLQKKGVDAASLEHLQTLFKTLKEANAKLEAAKAEQNSMSKLFGQYKREGKDITELKAKVDANKEAMVPLQEAAREAEEALYAVALAIPNLPDDSVPEGADEEDNVELIKVLEPRSFDFEPKEHWDLAEKNGWIDFERGVKLAKSRFSVLRGDAARLERALINFFLDTNRERGFEEFCVPFMNNAAMLQGTGQLPKFEDDLFKIEDEDLYLIPTAEVPLTNMYHDEILAEIDLPVLMTGYTPCFRKEAGSAGRDTRGMIRQHQFDKVEMVAIAHPDNSDEVFDMMVQNASDILTALGLPHRVVELCGGDLGFSAAKTIDLEVWLPGQNKYREISSISNTRDFQARRAKIRFKDGKKNRLVHTLNGSALAVGRTLIAIMENYQNEDGTIEIPEVLKKYM
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPD3_RAT
Sequence: MPRQFPKLNMSDLDEHVRLLAEKVFAKVLREEDSKDVMSLFTVPKDCPIGQKEAKERELQKELAEQKSVETAKRKKSFKMIRSQSMSLQMPTQDWKGPPSVSPAMSPTTPLVLGAASKPGLAPYDMPEYQRATISGDYCAGITMEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQYLAHQGESVPLEEGLPDFHPPPLPQEDPYCLDDAPPNLGYLVRMQGGVLFVYDNQTMLERQEPHSLPYPDLETYIVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKYTYQTEPDRTVAEKLGRKITLRQVFDSLHMDPYDLTVDSLDVHAGRQTFHGFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEDSKYQYSEPRLSIYGRSPKEWSSLARWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPSFGKMLENIFLPLFQATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDLWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALAD
What is the function of this protein?
AMP deaminase plays a critical role in energy metabolism.
What are the official names of this protein?
AMP deaminase 3, AMP deaminase isoform E.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Protein: FBX22_MOUSE
Sequence: MEPAGGGGGVSSSTDPRSTYVLSNLAEVVERVFTFLPAKALLRVAGVCRLWRECVRRVLRTHRSVTWISAGVAEAGHLEGHCLVRVVAEALENVRILPQTVLYMADSETFISLEECRGHKRARKRTTMETACALEKLFPKQCQVLGIVTPGIVVTPMGSGSNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDSKNLTLERHQLTEVGLLDNPELRVVLVFGYNCCKVGASNYLHRVVSTFSDMNIILAGGQVDNLSSLTCEKNPLDIDATGVVGLSFSGHRIQSATVLLTEDVNDAKTVEAAMQRLKAANIPEQNTIGFMFACVGRGFQYYRAKGNVEADAFRKFFPSVPLFGFFGNGEIGCDRIVTGNFILRRCNEVKEEDLFHSYTTIMALVHLGTSK
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.  Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
What are the official names of this protein?
F-box only protein 22.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, Z line.
Protein: RNH_PSEAE
Sequence: MTDKEQVVIYTDGACKGNPGRGGWGALLLYKGAERELWGGEPDTTNNRMELMAAIQALAALKRSCPIRLITDSEYVMRGITEWLPNWKKRGWKTASKQPVKNADLWQALDEQVARHQVEWQWVRGHTGDPGNERADQLANRGVAELPR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HI, RNase HI.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFPL_PSYIN
Sequence: MPKASDIKKNTAIEYNNNVYIIRDIERSVPQGRAGGSLYRMRMYDVVSGSKIDQTFKDNEMLPLADLVRRNVMFSYIDGEQYVFMDNEDYTPYNLDKDSIADEILLINEDTQGLQVVLVDGAPVALELPSSVELEIVETSPSIKGGSATARTKPAILSTGLTVQVPEHISTGDKIKVNTAEHKFMGRADK
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: OBG_RICPR
Sequence: MHFIDEVKIYIKGGNGGNGCISFHREKFIDRGGPDGGDGGFGGSVIFRSNHHINTLVNYRYQQHFTAENGENGKGSNRSGKSGKSLILDVPVGTQIFSQDGDILLYDFTEDEKSFEIIKGGCGGLGNSHFKTSVNQAPRKSTEGEIAEEMWIHLRLKLLSDVGLIGLPNAGKSTFLSVVTAAKPKIADYPFTTLVPNLGVVYIDDEEFVIADIPGLIAGAHQGYGLGDKFLKHIERCNVLIHLIDGASNNVIADYNTVRFELESYSDYLKNKIEIICLNKCDVLVDEEIQKKIKKLQKVTNKVVHPISTYNNQGVNKIVKLALEIIKNQKY
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_HALMA
Sequence: MVDWDVYLVTQASLSAGRTTDEIVAEAIESGVGVVQLREKNRTARERYELGQKLRELTREADVTFVVNDRIDLAQAIDADGVHLGDDDLPVSVARDILGDDAVIGRSVSTVEDAREAATAGADYLGVGAVFATGSKDDIDDEEYAVGTDRVAAIAEAVDIPFVGIGGITAGNATAVVDAGADGVAVITEITKADDPAAAAEALHSAVEQGR
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RS9_STRPB
Sequence: MAQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLIINQPFAVTSTEGSYDVFVNVVGGGYGGQSGAIRHGIARALLQVDPDFRDSLKRAGLLTRDARMVERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: H33_TOBAC
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPTTGGVKKPHRYRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSHAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes.  Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CYOE_HAHCH
Sequence: MKNTASTTAAAGWRDYYELCKPRVVALMMLTAVVGMLLASDQGMPWNALILGNLGIALLASSAAAINHIVDQKIDAVMARTQKRPIVQGRVDNVHALTFAFSLAVVGMAILAWGVNPLTAWLTLASLIGYAVVYTLFLKRATPQNIVLGGLAGAAPPLLGWTSVTGTVDPHALLLVLIIFAWTPPHFWALAVHRKDEYAKAGVPMLPVTHGDRYTKLHILLYTLMLFAASMLPFITGMCGWIYFVAALALGVRFLDWAWAMWRDSRKHAAIKTFRYSITYLMLLFVALLADHYIPVTLS
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYT5_RAT
Sequence: MFPEPPTPGSPAPETPPDSSRIRQGAVPAWVLATILLGSGLLVFSSCFCLYRKRCRRRMGKKSQAQAQVHLQEVKELGRSYIDKVQPEIEELDPSPSMPGQQVLDKHQLGRLQYSLDYDFQTGQLLVGILQAEGLAALDLGGSSDPYVSVYLLPDKRRRHETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVNLGRPVQAWRELQVAPKEEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGTAVGGAGLRHWADMLANPRRPIAQWHSLRPPDRARPIPAP
What is the function of this protein?
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.  Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells.  Required for export from the endocytic recycling compartment to the cell surface.
What are the official names of this protein?
Synaptotagmin-5, Synaptotagmin IX, Synaptotagmin V, SytV.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment.
Protein: RPOB_BUCAI
Sequence: MVYSYTEKKRIRKDFGKRPKVLDIPYLLSIQLNSFKKFIQPDLSGQHGLEAAFRSVFPIRGYNGNSELQYVSYRLGETIFDVKECQIRGATYSAALRVKLRLVIYERDILEATVKDIKEQEVYMGEIPLMTNNGTFIINGTERVVVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPVSIILRALNYNTEEILNIFFEKNIFKIENNKIVLELVPERLRGETASFNIKKNGIIYVEKGRRITAKHIQELKNNKIKSITVPVEYILGRIVSKNYVDKKTGETIISSNTELSLEILEKLKKLGFYSIETLFTNDLDHGPYISETLRIDSSNDRMSALIEIYRVMRPGEPPTKEATENLFENLFFSEDRYDLSTVGRMKFNRSLLREETKGSSTLNKEDIIDVIKKIIDIRNGKGEVDDIDHLGNRRVRSVGEMAENQFRIGLVRVERAVKERLSIGDLDALMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGLGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNSHGFLETPYRKVCNGLVSEEIHYLSAIEEGNYIIAQANTNIDKTGFFTDDLVTCRHKGESSLFNRNQVNYMDVSTQQIVSVGASLIPFPEHDDANRALMGANMQRQAVPTLKTDKPLIGTGMERAVAVDSGVTAVAKRSGVVQYVDASRIVIKVDEKEMYSREAGIDIYNLTKYTRSNQNTCINQQPCVNLGEKIKKGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELSCISRDTKLGAEEISSDIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQIFTRDGVKKDKRALEIEDMQLKKIKQDLTEEFKIFESSLFTHIKKTFISLDIETKQLDTLPFEKWFSVDIKQKDKKKEIEKLAKQHHELKEEFNKKIEIKRQKITQGDDLAPGVLKIVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGIPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINHMLKTQEKISNLRKFIQKAFDLGDNLRQKVNLDTFSNEEILRLAKNLKNGIPISTPVFDGAQENEIKQMLKFAGLPTSGQIILFDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEIRSLGINIELESE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RI2BC_ARATH
Sequence: MPSMPEEPILTPTPDRFCMFPIQYPQIWEMYKKAEASFWTAEEVDLSQDNRDWENSLTNDERHFIKHVLAFFAASDGIVLENLSTRFMSDVQISEARAFYGFQIAIENIHSEMYSLLLDTYIKDNKERDHLFRAIETIPCDEKSRMGYEMDQRISKLR
What are the official names of this protein?
Putative ribonucleoside-diphosphate reductase small chain B, Ribonucleoside-diphosphate reductase R2B subunit, Ribonucleotide reductase small subunit B.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family.
Protein: RHAA_SHISS
Sequence: MTTQLEQAWELAKQRFAAVGIDVEEALRQLDRLPVSMHCWQGDDVSGFENPEGSLTGGIQAIGNYPGKARNASELRADLEQAMRLIPGPKRLNLHAIYLESDTPVSRDQIKPEHFKNWVEWAKANQLGLDFNPSCFSHPLSADGFTLSHPDDSIRQFWIDHCKASRRVSAYFGEQLGTPSVMNIWIPDGMKDITVDRLAPRQRLLAALDEVISEKLDPAHHIDAVESKLFGIGAESYTVGSNEFYMGYATSRQTALCLDAGHFHPTEVISDKISAAMLYVPQLLLHVSRPVRWDSDHVVLLDDETQAIASEIVRHDLFDRVHIGLDFFDASINRIAAWVIGTRNMKKALLRALLEPTAELRKLEAAGDYTARLALLEEQKSLPWQAVWEMYCQRHDTPAGSEWLESVRAYEKAILSQRG
What is the function of this protein?
Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
What are the official names of this protein?
L-rhamnose isomerase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PER_DROME
Sequence: MEGGESTESTHNTKVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICRELQDQQHGEDHSEPQAIEQLQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKLELPHENELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSGTGTGTASSSKGGTAAIPPVTLTESLLNKHNDEMEKFMLKKHRESRGRTGEKSKKSANDTLKMLEYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGSSTPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKHPHKGGTDMPTTSQQAAAAAAQAMPLQYMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFPGMANALQIPERPLGSQSAYNKSVYTTTPASMTKKVPGAFHSVTTPAQVQRPSSQSASVKTEPGSSAAVSDPCKKEVPDSSPIPSVMGDYNSDPPCSSSNPANNKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPDTEKDPKHRKLKSMSTSESKIMEHPEEDQTQHGDG
What is the function of this protein?
Essential for biological clock functions.  Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms.  Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system.  The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex.  Light induces the degradation of TIM, which promotes elimination of PER.  Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop.  Behaves as a negative element in circadian transcriptional loop.  Does not appear to bind DNA, suggesting indirect transcriptional inhibition.  Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361).
What are the official names of this protein?
Period circadian protein, Protein clock-6, CLK-6.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization.