PharMolix/UniProtQA huggingface dataset:
Protein: ROCA_BACHK
Sequence: MVVAYKHEPFTDFSVEANKLAFEEGLKKVESYLGQDYPLIIGGEKITTEDKIVSVNPANKEELVGRVSKASRELAEKAMQVADETFQTWRKSKPEMRADILFRAAAIVRRRKHEFSAILVKEAGKPWNEADADTAEAIDFMEYYGRQMLKLKDGIPVESRPIEYNRFSYIPLGVGVIISPWNFPFAIMAGMTTAALVSGNTVLLKPASTTPVVAAKFMEVLEEAGLPAGVVNFVPGNGSEVGDYLVDHPRTRFISFTGSRDVGIRIYERAAKVNPGQIWLKRVIAEMGGKDTIVVDKEADLELAAKSIVASAFGFSGQKCSACSRAVIHEDVYDHVLNRAVELTKELTVANPAVLGTNMGPVNDQAAFDKVMSYVAIGKEEGRILAGGEGDDSKGWFIQPTIVADVAEDARLMKEEIFGPVVAFCKAKDFDHALAIANNTEYGLTGAVISNNRDHIEKAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLALHMQAKTTSETL
What are the official names of this protein?
1-pyrroline-5-carboxylate dehydrogenase, P5C dehydrogenase, L-glutamate gamma-semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. RocA subfamily.
Protein: RIHC_ECOSE
Sequence: MRLPIFLDTDPGIDDAVAIAAAIFAPELDLQLMTTVAGNVSVEKTTRNALQLLHFWNAEIPLAQGAAVPLVRAPRDAASVHGESGMAGYDFVEHNRKPLGIPALLAIRDALMRAPEPVTLVAIGPLTNIALLLSQCPECKPYIRRLVIMGGSAGRGNCTPNAEFNIAADPEAAACVFRSGIEIVMCGLDVTNQAILTPDYLSTLPQLNRTGKMLHALFSHYRSGSMQSGLRMHDLCAIAWLVRPDLFTLKPCFVAVETQGEFTSGTTVVDIDGCLGKPANVQVALDLDVKGFQQWVAEVLALAS
What is the function of this protein?
Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.
What are the official names of this protein?
Non-specific ribonucleoside hydrolase RihC, Purine/pyrimidine ribonucleoside hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihC subfamily.
Protein: ATG8_USTMA
Sequence: MRSAFKNEHSFEKRKAEAERIRQKYPDRIPVICEKADRTDIPTIDKKKYLVPSDLTVGQFVYVIRKRIKLAPEKAIFIFVDEVLPATAALMSAIYEEHKDEDGFLYVSYSGENTFGQL
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).  Required for selective autophagic degradation of the mitochondria (mitophagy) which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Required for wild-type budding of haploid sporidia and for complete symptom development during pathogenic growth such as gall formation and teliospore production in ears of mature maize (PubMed:20618705, PubMed:22843561).
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier atg8.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor.
Protein: GLGB_KLULA
Sequence: MTGDNNDIPENVRGVVEIDSWLTPFAKVLSERRYLADEWRYKIEHSTNSEGRDTTLAQFARDAYKSFGLHADPGSLEIRYKEWAPNAVRAFLIGEFNSWNENANEMQRDEYGIFTTVVPPVVDDSGNKQYGIPHDSKVKVCFQLADGSRIYRLPAWITRATQPDKETAKQWGPSYEARFWNPPVHYSFKNKRPGFMRDTDSLRIYEAHVGISTPEPKVGSYKEFTQNVLPRIKDLGYDAIQLMAIMEHAYYASFGYQVTNFFAASSRFGTPDELKELVDTAHGMGILVLLDVVHSHASKNVTDGLNQFDGSDHQYFHSLASSRGEHPLWDSRLFNYGHFEVQRFLLANLAFYIDVYQFDGFRFDGVTSMLYLHHGVGEGGAFSGDYNEYLSSERSFVDHEALAYLMLANDLVRELLPDNGITIAEDVSGYPTLCMPRHLGGAGFDYRLAMALPDMWIKLLKESRDEDWEMGHIVHTLVNRRHREKVVAYTESHDQALVGDKTLAFWLMDAAMYTDMTILKESTPVVDRGIALHKLIRLITHSLGGEAYLNFEGNEFGHPEWLDFPNVNNGDSYHYARRQFNLVDDPLLRYQYLYQFDKAMQTTEKNYKWLNTPQAYVSLKHEVDKVIAFERNGLLFIFNFHPTESFTDYRIGVNEPGCYRIVLNSDKHEYGGWDRIDESQSKYFTTDLKWNERNNFIQVYIPNRTALVLALDSRVRNGN
What are the official names of this protein?
1,4-alpha-glucan-branching enzyme, Glycogen-branching enzyme.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: MURC_THEP1
Sequence: MKIHFVGIGGIGMSAVALHEFLNGNDVYGSNIEETERTAYLRKLGIPIFVPHSADNWYDPDLVIKTPAVRDDNPEIVRARMERVPVENRLHYFRDILKREKKEEFAVTGTDGKTTTTAMVAHVLKHLKKSPTVFLGGIMDSLEHGNYEKGNGPVVYELDESEEFFSEFSPNYLIITNARGDHLENYGNSLSRYRSAFEKISRNTDLVVTFAEDELTSHLGDVTFGVKKGTYTLEMRSASRAEQKAVVEKNGKRYLELKLKVPGFHNVLNALAVIALFDSLGYDLAPVLEALEEFRGVHRRFSIAFHDPETNIYVIDDYAHTPDEIRNLLQTAKEVFENEKIVVIFQPHRYTRLEREDGNFAKALQLADEVVVTEVYDAFEERKNGISGKMIWDSLKSLGKEAYFVEKLPELEKVIPVSENTVFLFVGAGDIIHSSRRFVERYQSSKSSPSRVLGSNK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN148_BOVIN
Sequence: MNIDDKLEGLFLKCGGIDEMQSSRAMVVMGGVSGQSTVSGELQESVLQDRSMPHQEILAADEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITFTDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESSLDKSDLKKDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEESKVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILDSQALNVEIKSNHDKNVIPDEVLQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTQSENVGSSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFRSGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFPEFPLVNVNDNRAGMTSSPDATTGQTFG
What is the function of this protein?
Involved in transcriptional regulation.  Represses the transcription of a number of genes including gastrin, stromelysin and enolase.  Binds to the G-rich box in the enhancer region of these genes (By similarity).
What are the official names of this protein?
Zinc finger protein 148, Transcription factor ZBP-89, Zinc finger DNA-binding protein 89.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: X_HBVA7
Sequence: MAARLCCQLDPSRDVLCLRPVGAESRGRPLSGPLGTLSSPSPSAVPADHGAHLSLRGLPVCAFSSAGPCALRFTSARCMETTVNAHQSLPKVLHKRTLGLPAMSTTDLEAYFKDCVFKDWEELGEEIRLMIFVLGGCRHKLVCAPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: SKP_SALTI
Sequence: MKKWLLAAGLGLAMVTSAQAADKIAIVNMGNLFQQVAQKTGVSNTLENEFKGRAAELQKMETDLQSKMQRLQSMKAGSDRTKLEKDVMSQRQTFAQKAQAFEKDRARRSNEERNKLVTRIQTAVKKVANDQSIDLVVDANTVAYNSSDVKDITADVLKQVK
What is the function of this protein?
Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.
What are the official names of this protein?
Chaperone protein Skp.
What is the protein family that this protein belongs to?
Belongs to the Skp family.
What are the subcellular locations of this protein?
Periplasm.
Protein: E4PD_AERHH
Sequence: MIKIAINGYGRIGRNVLRALYESGRDKNIKIVAINELAAPEAMVHLTRFDTSHGRFHHPVQLAGNSMLVGEDLISLFAERDPSRLPWRALGVDVVLDCTGVFGSRADAELHLAAGAGKVLFSHPAEADVDATIVYGVNHQVLTGRERIVSNASCTTNCVVPVIETLHREFEINCGTITTIHSAMHDQQVIDAYHSDLRRTRAASQSIIPVDTKLAKGLERILPHFAGKFEAIAVRVPTINVTAMDLSITVRKKVTVTDVNQALQRASRGTLSGILDYTEEPLVSVDFNHDAHSCIIDGTQTRVSDANLVKMLMWCDNEWGFANRMLDTTRAMMAAG
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1072_STAA8
Sequence: MNLIPRTSIVVYLKHMKHERQIRKYGHIVHSNRDRKFVIMYVNEQDVDQIVHKLMQLKYVRHIDGSPYKYLKKTYEKEKHEIYN
What are the official names of this protein?
UPF0298 protein SAOUHSC_01072.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHX1_SCHPO
Sequence: MRSYSNPENGGQINDNINYSEKRPTMLPENLSLSNYDMDSFLGQFPSDNNMQLPHSTYEQHLQGEQQNPTNPNYFPPEFDENKVDWKQEKPKPDAPSFADNNSFDNVNSSKLTNPSPVQPNIVKSESEPANSKQNEVVEATSVEKAKENVAHESGTPESGGSTSAPKSKKQRLTADQLAYLLREFSKDTNPPPAIREKIGRELNIPERSVTIWFQNRRAKSKLISRRQEEERQRILREQRELDSLNQKVSQAFAHEVLSTSPTSPYVGGIAANRQYANTLLPKPTRKTGNFYMKSGPMQSSMEPCIAESDIPIRQSLSSTYYNSLSPNAVPVSSQRKYSASSYSAIPNAMSVSNQAFDVESPPSSYATPLTGIRMPQPESDLYSYPREVSPSSGGYRMFGHSKPSSYKASGPVRPPNMATGHMRTSSEPTSYDSEFYYFSCTLLVIGLWKRLRASPQDLMCFYSPPKKLFAYLIQFQGIQYRIEYSFFVIESIHVFRVEEPLLNELSATASSRDKPAPNEYWLQMDIQLSVPPVFHMITSEGQGNCTDFTEGNQASEVLLHSLMGRATSMFQMLDRVRRASPELGSVIRLQKGLNPHQFLDPQWANQLPRQPDSSVFDHQGRNPPIQGLSHDTSSEYGNKSQFKRLRSTSTPARQDLAQHLLPPKTNTEGLMHAQSVSPITQAMKSANVLEGSSTRLNSYEPSVSSAYPHHNLALNLDNTQFGELGTSNISYPLSAPSDVGSLPRASNSPSRPVMHPNTQGINTEIKDMAAQFPNSQTGGLTPNSWSMNTNVSVPFTTQNREFGGIGSSSISTTMNAPSQQLSQVPFGDVSLATENSVPSYGFEVPSEESVYAQARTNSSVSAGVAPRLFIQTPSIPLASSAGQDSNLIEKSSSGGVYASQPGASGYLSHDQSGSPFEDVYSPSAGIDFQKLRGQQFSPDMQ
What is the function of this protein?
Trnascription factor that regulates the expression of the homocitrate synthase (HCS) lys4.
What are the official names of this protein?
Homeobox transcription factor phx1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS2_MYCPA
Sequence: MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTFIDKAYEFVKETVAHGGTVLFVGTKKQAQESIAAEATRVGMPYVNQRWLGGMLTNFSTVHKRLQRLKELEAMEQTGGFEGRTKKEILGLTREKNKLERSLGGIRDMSKVPSAIWVVDTNKEHIAVGEARKLGIPVIAILDTNCDPDEVDYPIPGNDDAIRSAALLTKVIASAVAEGLQARAGVGRGDGKPEVEAAEPLAEWEQELLASATATAAPTEAGAPEPTTDPS
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: LPXB_SHIFL
Sequence: MTDQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNGARDVLGIPYDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: ECFT_BREBN
Sequence: MLQNIAIGQYVPGQSFLHRADPRSKLLFIILFATLIFLANNTVTYAILIGFTLYAALLSRLSLSYILKSLKPVWILILFTVVLHIFITKGGTVYFQWGWFTVEEQGVRQAIFISLRLGLLILISSLLTLTTSPIDLTEGLERLLGPLGKIGIPVHDIALMMSIALRFIPTLMEETDKIIKAQTARGANFTSGSLVRRAKNLIPIAIPLFVSAFRRAEELALAMEARGYRGGVGRTRLNKLTFTWRDGIVAVVSVILVIVIGWWRT
What is the function of this protein?
Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter transmembrane protein EcfT, ECF transporter T component EcfT.
What is the protein family that this protein belongs to?
Belongs to the energy-coupling factor EcfT family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AMBP_BOVIN
Sequence: MRSLSGLLLLLTACLAVNASSVPTLPDDIQVQENFDLSRIYGKWFNVAVGSTCPWLKRFKEKMTMSTVVLIAGPTSKEISVTNTHRRKGVCESISGTYEKTSADGKFLYHKAKWNITMESYVVHTNYDEYAIFLTKKLSRRHGPTITVKLYGREPQLRESLLEEFREVALGVGIPEDAIFTMPDRGECVPGEQDPVPTPLSRARRAVLTQEEEGSGAGQPVTNFSKKADSCQLDYSQGPCLGLFKRYFYNGTSMACETFLYGGCMGNGNNFLSEKECLQTCRTVEACNLPIVQGPCRSYIQLWAFDAVKGKCVRFSYGGCKGNGNKFYSEKECKEYCGIPGEADEELLRFSN
What is the function of this protein?
Kunitz-type serine protease inhibitor.  Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation.  Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
What are the official names of this protein?
Protein AMBP.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
[Alpha-1-microglobulin]: Secreted. Endoplasmic reticulum. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Nucleus membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Secreted, extracellular space, extracellular matrix. Note=The cellular uptake occurs via a non-endocytotic pathway and allows for localization to various membrane structures. A specific binding to plasma membrane suggests the presence of a cell receptor, yet to be identified. Directly binds collagen fibers type I.
Protein: DD3_DICDI
Sequence: MRFLSSLIILLIITIYSSVNGDIYMHSPPGSNNRNQEQGQNRDNNQRLFNSQNNDKGGYCRGEALEWYEKSYLPVEWTNQHGCGSGETECNIVIQYMCTDNAKAADTEYIRDGTVTTTISANDITQSSTKETNEYKFGMHESYHHYQNCTGRERNKGLFIANQNIGNNADRTRQSNNGNNYGYECQEERDYYPYWAPSPWKDVAIITDNRDLCKWYRSESQNVQPKYYCKAATTNNNQPRSIDPVICANQGGVWTKVDSHDIGAPECIKAEWTQVNTLGHVLEDGHNPMYNWSLPHSGMEPCIATGTCSCVLRVRYNISSSDLKGNGDEFTDYKSNGPKGATNVNDPNVVVAGQNVTLNINPNQYGRTFQDRSHVFSIIARPDSLKKAKIWNLLVKGKRGNIVQSHPAQEYQFVPKTLHIKVNEYIHYQWTGCDFNPQNYDGTGIKGSDRSNMCQIKTLNHNYPMTDDELNDDNALFADMETRLRFARLGQKSCLTYDELMTKNNNNKDAVEVDPQNCMVLNNAGTRFNGGVQKMSKTGSYYYMSTRNNNFSNRNQKGAIHVDPLLAGWQIGLIASGCSLFVIISATAGCVTFARFHPHSGMHRAVSKVPGLKRLV
What is the function of this protein?
May participate in O-glycosylation.
What are the official names of this protein?
Protein DD3-3.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ALDOB_DANRE
Sequence: MTHQFPALSTEQKKELATIAERIVAPGKGILAADESTGTMAKRFQKINVENTEENRRSFRDLLFSVDDSISESIGGVILFHETLYQKSDKGVLFPKVIKDKGIVVGIKVDKGTAGLAGTDGETTTQGLDGLSERCAQYKKDGCDFAKWRCVLKISDSCPSALGIAENANVLARYASICQQNGLVPIVEPEILPDGDHDLKQCQYATEKVLAAVYKALSDHHVYLEGTLLKPNMVTAGHSCTKKYTPLEVAMATVTALRRTVPAAVPGICFLSGGQSEEEASLNLNAMNQLSLHRPWKLSFSYGRALQASALSAWKGQAANKKASQDAFVTRAKINSLASKGEYKPSGQAGQASTQSLFTASYTY
What are the official names of this protein?
Fructose-bisphosphate aldolase B, Liver-type aldolase.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Protein: RL2B_SCHPO
Sequence: MGRVIRAQRKSGGIFQAHTRLRKGAAQLRTLDFAERHGYIRGVVQKIIHDPGRGAPLAKVAFRNPYHYRTDVETFVATEGMYTGQFVYCGKNAALTVGNVLPVGEMPEGTIISNVEEKAGDRGALGRSSGNYVIIVGHDVDTGKTRVKLPSGAKKVVPSSARGVVGIVAGGGRIDKPLLKAGRAFHKYRVKRNCWPRTRGVAMNPVDHPHGGGNHQHVGHSTTVPRQSAPGQKVGLIAARRTGLLRGAAAVEN
What are the official names of this protein?
60S ribosomal protein L2-B, K37, K5, KD4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: IL2_LAMGL
Sequence: MYKLQLLSCIALTLALVANSAPTLSSTKDTKKQLEPLLLDLQFLLKEVNNYENLKLSRMLTFKFYMPKKATELKHLQCLMEELKPLEEVLNLAQSKNSHLTNIKDSMNNINLTVSELKGSETGFTCEYDDETVTVVEFLNKWITFCQSIYSTMT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBIA_CUPPJ
Sequence: MSERLALYARLVRIDKPIGTLLLLWPTLWALWMAAGGPPALSVFCIFFAGTFLMRSAGCAINDYADRDFDKHVKRTKERPLTAGKIAAWEAVLIAAVLALIAFALILPLNSLTKWLAVVAAVVAGTYPFFKRFFAIPQAYLGIAFGFGIPMAFAAVQDQVPLVAWVMLLANVFWAVAYDTAYAMVDRDDDLLIGIKTSAITFGRFDVAAIMLCYAAFLVLMGWAGVMLSLGWPYWVGLAAAAVCAGYHYTLIRDRDRMRCFAAFRHNNWLGACVFAGTAVAYAIR
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VPS25_RAT
Sequence: MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQIVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTSGEDTEEEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF
What is the function of this protein?
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.  The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation.  The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).  The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL.
What are the official names of this protein?
Vacuolar protein-sorting-associated protein 25, ELL-associated protein of 20 kDa, ESCRT-II complex subunit VPS25.
What is the protein family that this protein belongs to?
Belongs to the VPS25 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane. Nucleus. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6.
Protein: IL10_PIG
Sequence: MPSSALLYCLIFLAGVAASIKSENSCIHFPTSLPHMLRELRAAFGPVKSFFQTKDQMGDLLLTGSLLEDFKGYLGCQALSEMIQFYLEDVMPKAESDGEDIKEHVNSLGEKLKTLRLRLRRCHQFLPCENKSKAVEEVKSAFSKLQERGVYKAMGEFDIFINYIEAYMTMKMRKN
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL27_SYNC1
Sequence: MAHKKAGGSSKNGRDSAGKRLGVKRFGGQQVTAGSILVRQRGTTIHPGANVGCGKDYTLYALVDGVVSFERKGKDKKKVSVYAQ
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PRO1_CAEEL
Sequence: MAYLGVDTSRIAGTQPLEMLLVSSGSPDPHSTIIIDPRTGVSSWSYKGSELQGASTGLVEPLGHDGEHVVITTKERPLVHVLAVHPKDRFHQKCVLPGPVSAIVSDNSGHFVFMSIKRQLYCWLLSTGELLSVIDAHYQNITKIVISDDDSMIFTASKDGAVHGYLVTDLVSADRDHTVAPFRKWASHTLSISDLKITNGSNPRVLSAGADHIACLHSISMDSVILKASSDRPLTACAIDPAETRIFIGTEVGNIAQINLFQLAPEERDLLVQAGDEHNTKFRVLNGHSDEISRLAINTDGTLLASGDASGKYCIWEISSHQCLKVSTMRSVINTLRFIPFWKTISGGEHVAKFRPVWDLKREPTKCDRFAIEVSTEFNSDQKHWNDVIEETIDQLLLESGSKSSAQLQWDAEGPARNEAAKAEKAAENTIKNIITLGDDEDDAPEVGNQRRKSGKKNKKNRKNQKKNDFEAAVIEKKQVEPIVIDDEEEVNSSLQKKFDALKAENEKLKEINKQMYEFVAKEIVDSEK
What is the function of this protein?
Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity).  Required for processing ITS2 sequences from rRNA intermediates during 26S rRNA maturation (PubMed:16876152).  Required in the soma to promote normal proliferation and prevent germline tumor formation (PubMed:14973273).
What are the official names of this protein?
Pre-rRNA-processing protein pro-1, Proximal proliferation in germline protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat IPI3/WDR18 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.