Protein: EIN2_ARATH
Sequence: MEAEIVNVRPQLGFIQRMVPALLPVLLVSVGYIDPGKWVANIEGGARFGYDLVAITLLFNFAAILCQYVAARISVVTGKHLAQICNEEYDKWTCMFLGIQAEFSAILLDLTMVVGVAHALNLLFGVELSTGVFLAAMDAFLFPVFASFLENGMANTVSIYSAGLVLLLYVSGVLLSQSEIPLSMNGVLTRLNGESAFALMGLLGASIVPHNFYIHSYFAGESTSSSDVDKSSLCQDHLFAIFGVFSGLSLVNYVLMNAAANVFHSTGLVVLTFHDALSLMEQVFMSPLIPVVFLMLLFFSSQITALAWAFGGEVVLHDFLKIEIPAWLHRATIRILAVAPALYCVWTSGADGIYQLLIFTQVLVAMMLPCSVIPLFRIASSRQIMGVHKIPQVGEFLALTTFLGFLGLNVVFVVEMVFGSSDWAGGLRWNTVMGTSIQYTTLLVSSCASLCLILWLAATPLKSASNRAEAQIWNMDAQNALSYPSVQEEEIERTETRRNEDESIVRLESRVKDQLDTTSVTSSVYDLPENILMTDQEIRSSPPEERELDVKYSTSQVSSLKEDSDVKEQSVLQSTVVNEVSDKDLIVETKMAKIEPMSPVEKIVSMENNSKFIEKDVEGVSWETEEATKAAPTSNFTVGSDGPPSFRSLSGEGGSGTGSLSRLQGLGRAARRHLSAILDEFWGHLYDFHGQLVAEARAKKLDQLFGTDQKSASSMKADSFGKDISSGYCMSPTAKGMDSQMTSSLYDSLKQQRTPGSIDSLYGLQRGSSPSPLVNRMQMLGAYGNTTNNNNAYELSERRYSSLRAPSSSEGWEHQQPATVHGYQMKSYVDNLAKERLEALQSRGEIPTSRSMALGTLSYTQQLALALKQKSQNGLTPGPAPGFENFAGSRSISRQSERSYYGVPSSGNTDTVGAAVANEKKYSSMPDISGLSMSARNMHLPNNKSGYWDPSSGGGGYGASYGRLSNESSLYSNLGSRVGVPSTYDDISQSRGGYRDAYSLPQSATTGTGSLWSRQPFEQFGVAERNGAVGEELRNRSNPINIDNNASSNVDAEAKLLQSFRHCILKLIKLEGSEWLFGQSDGVDEELIDRVAAREKFIYEAEAREINQVGHMGEPLISSVPNCGDGCVWRADLIVSFGVWCIHRVLDLSLMESRPELWGKYTYVLNRLQGVIDPAFSKLRTPMTPCFCLQIPASHQRASPTSANGMLPPAAKPAKGKCTTAVTLLDLIKDVEMAISCRKGRTGTAAGDVAFPKGKENLASVLKRYKRRLSNKPVGMNQDGPGSRKNVTAYGSLG
What is the function of this protein?
Trafficking signal inducing ethylene response.  The nuclear localization is both necessary and sufficient to activate EIN3-mediated transcription and ethylene responses (PubMed:23070300).  Involved in ethylene (ET)-mediated signaling pathways by triggering histone acetylation of H3K14 and H3K23 in an ENAP1-dependent manner, thus influencing the expression of ethylene-responsive genes (PubMed:27694846, PubMed:28874528).  Necessary and sufficient for 3'-UTR-mediated translational repression of EBF1 and EBF2 mRNAs.  Ethylene induces EIN2-CEND to associate with 3' UTRs in cytoplasmic foci and target EBF1/2 mRNAs to cytoplasmic processing-body (P-body) (PubMed:26496607, PubMed:26496608).  MPK6 regulates the cleavage and nuclear translocation of EIN2-CEND under methyl jasmonate treatment (PubMed:26507893).  Required for EIN3 accumulation (PubMed:26507893).
What are the official names of this protein?
Ethylene-insensitive protein 2, AtEIN2, EIN-2, Cytokinin-resistant protein AtCKR1, Protein ORESARA 3.
What is the protein family that this protein belongs to?
Belongs to the NRAMP (TC 2.A.55) family.
What are the subcellular locations of this protein?
[Ethylene-insensitive protein 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [EIN2-CEND]: Nucleus. Cytoplasm. Endoplasmic reticulum membrane. Note=Perception of ethylene or methyl jasmonate leads to proteolytic cleavage allowing the C-terminal domain to localize to the nucleus while the N-terminus remains at the endoplasmic reticulum membrane. Apart from nuclear localization, some association with endoplasmic membranes and some speckles are also observed in the cytoplasm. During hypoxia (e.g. submergences), translocates from endoplasmic reticulum (ER) to the nucleus via a ceramides-triggered and CTR1-dependent manner (PubMed:25822663).