PharMolix/UniProtQA huggingface dataset:
Protein: FENR1_TOBAC
Sequence: MATAVSAAVSLPSSKSTSFSSRTSIISTDKINFNKVPLYYRNVSGGSRLVSIRAQVTTEAPAKVEKISKKQDEGVIVNKFRPKEPYVGRCLLNTKITGDDAPGETWHMVFSTEGEVPYREGQSIGVIADGVDANGKPHKLRLYSTASSALGDFGDSKTVSLCVKRLVYTNDKGEEVKGVCSNFLCDLKPGAEVKITGPVGKEMLMPKDPNATVIMLATGTGIAPFRSFLWKMFFEKHEDYKFNGTAWLFLGVPTSSSLLYKEEFEKMKEKAPENFRLDFAVSREQTNEKGEKMYIQTRMAQYAEELWTLLQKDNTFIYMCGLKGMEQGIDEIMSALAERDGIVWADYKKQLKKAEQWNVEVY
What is the function of this protein?
May play a key role in regulating the relative amounts of cyclic and non-cyclic electron flow to meet the demands of the plant for ATP and reducing power.
What are the official names of this protein?
Ferredoxin--NADP reductase, leaf-type isozyme, chloroplastic, FNR.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Note=In the vicinity of the photosystem I in the non-stacked and fringe portion of the membrane.
Protein: AROA_MYCSS
Sequence: MDGVSNWPAPSTPTPVHATLTIPGSKSQTNRALVLAALATPQGTSTISGALRSRDTDLMIGALQTLGFDVESAGTDSDLRVGGGLGPAAGARVDCGLAGTVLRFLPPVAALSTETVEFDGDEQARARPIAPLLAGLQALGVRIDGDGLPFRVRGEGSVAGGTVEIDASASSQFVSGLMLSGALFRDGLTIVHTGESVPSAPHVAMTVSMLRDAGVEVDDTKTNRWTVRPGPVAARHWTIEPDLSNAVPFLSAGVVSGGAVRITGWPAVSTQPAGAIMAILEKVGAVVRQTESYLEVQGTRQYQGFDVDLHDVGELTPAVAALAAVATPGAVSRLRGVAHLRGHETDRLAALSAEINGLGGQCEETDDGLVITAAPLHGGVWHSYADHRMAMAGAIVGLRTPGVEIEDIATTAKTLPEFPQMWADMLAGQTATDPEAGA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_RICCK
Sequence: MSTNQIILTDQGDNYLNVWSHVAQDLYNHYGETLYNSWFSKVNFIESSLNTVILCAPTNFVRDWIKSKYSMVILQLFQHYNNTIKSVEIITKELPGTSKTVIELPTKTFADIGSSELNAENIFSTLDVRFTFDNFVVGVPNELAYAAARAVAESTDAVSESNPLFLYGGVGLGKTHLMHAIGWYIKQNNPNRKVIYMSAEKFMYQFVKALRNKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLIDNNRQIVISCDRSPSDLDNIEDRIKSRLGWGLVADVHSTTYELRLGILESKIEQMNVKIPKNVIDFLASKIVSNVRELEGALNKVIAHSNFTLKEITLENTQNILRDLLRSNERIITVEDIQKKVASRYNIKLSDMSSSRRLREVARPRQIAMYLSKTLTPKSLADIGKKFGKKDHTTVMHAIKKVEELLENDIELREEINLLMKILQN
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSZ_METTH
Sequence: MKFINDAIKESEKREKPSSSSMNSEIDRELREIIENSRAKIYVVGTGGAGNNTVTRLSEIGVEGAETIAVNTDAQDLFYSVANRKLLIGKNVCGGLGAGGVPEVGEECAEESEDDIRRELEGADMVFVTCGLGGGTGTGSAPVISKLAKKAGALTIAVATMPFSAEGLKRRENAERGLEKLQSAADTVIVIPNDKLLEVAPNLPLNKAFMVADEILGRAVKGITELITKPGLVSLDFADVRSIMKGSGMAMIGMGEAESGDRALESVYEALNSPLLDLDISNARGALINISGSSDLTLQEAERIVEVVAEELDPDANIIWGAQIQDELQNVIRTTIVVAGVRSPYIYGAHGSAEKEFLEEKQREKDSVDESVLEEFIDGVF
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.
What are the official names of this protein?
Cell division protein FtsZ.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: SUCC_BURM9
Sequence: MKIHEYQGKEILRKFGVAVPRGKPAFSVDEAVKVAQELGGPVWVVKAQIHAGGRGKGGGVKVAKSLEQVREYSNQILGMQLKTHQTGPEGQKVNRLLIEEGADIKKELYVGIVIDRVSQKVVVMASSEGGMDIEEVAEKTPEAIHKVAVEPSVGLQDAEADDLAKKIGVPDASIPQAREILKGLYKSFWETDASLAEINPLVLTGDGKVIALDAKFNFDSNALFRHPEIVAYRDLDEEDPAEIEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATTEKVTEAFKLMLKNPGLKAILVNIFGGIMRCDVIAEGVIAGSKAVNLNVPLVVRMKGTNEDLGKKMLAESGLPIISADSMEEAAQKVVAAAAGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: Y3945_BACC4
Sequence: MLEKTTRMNYLFDFYQSLLTQKQRSYMSLYYLDDLSLGEIAEEFDVSRQAVYDNIKRTEAMLEEYEEKLVLLQKFQERQRLVAKLKQLISEEEHVNEEMKQVVEAIEKLD
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein BCB4264_A3945.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: NS1_I59A0
Sequence: MDSNTVSSFQVDCFLWHVRKRFADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILEEESDEALKMTIASVPASRYLTDMTLEEMSRDWFMLMPKQKVAGSLCIRMDQAIMDKNIILKANFSVISDRLETLILLRAFTEEGAIVGEISPLPSLPGHTDEDVKNAIGVLIGGLEWNDNTVRVSETLQRFAWRSSNEDGRPPLPPKQKRKMARTIESEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: ASPS2_ECOH1
Sequence: MSIKQMPGRVLISLLLSVTGLLSGCASHNENASLLAKKQAQNISQNLPIKSAGYTLVLAQSSGTTVKMTIISEAGTQTTQTPDAFLTSYQRQMCADPTVKLMLTEGINYSITINDTRTGNQYQRKLDRTTCGIVKA
What is the function of this protein?
Part of a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane (Probable).  Required for correct assembly of the type II secretion system-beta (T2SS-beta), for localization of GspD-beta to the cell outer membrane and for export of a labile enterotoxin by T2SS-beta (PubMed:22585966).  Each AspS2 binds to 2 GspD2 subunits and may clamp the monomers together, stabilizing structure and accelerating its assembly (PubMed:29632366).
What are the official names of this protein?
Pilotin AspS 2, Type II secretion system-beta protein GspS-beta.
What is the protein family that this protein belongs to?
Belongs to the GspS/AspS pilotin family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side. Note=Protein can also be located in the cell inner membrane.
Protein: RLMB_BORPE
Sequence: MASTQVLAGFHAVVARLRHAPESIKEIYVEASRRDKRMQTFLEQAERAGRRVHPVAAERLDGLARGTRHQGVVAVAEERSLAVGIDEVLDVIEGPALLLILDGVTDPHNLGACLRTADAAGVHAVIAPRDRAVGLNATVQRVACGAADTVPYLTVTNLARTMRELKERDVWLVGTDDQAGESMHQVDARRSMAWVMGAEGEGMRRLTRETCDQLVRIPMLGSVESLNVSVASAVCLYESVRQRQG
What is the function of this protein?
Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
What are the official names of this protein?
23S rRNA (guanosine-2'-O-)-methyltransferase RlmB, 23S rRNA (guanosine2251 2'-O)-methyltransferase, 23S rRNA Gm2251 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_ACIBT
Sequence: MTQSVCILGVTGSIGRSTLKILGQHPDKYSVFAVSAHSRISELVEICKQFRPKVVVVPEQKIAELKTLFAQQNISDIDVLAGQEGLVDIASHTDVDIVMAAIVGAAGLLPTLAAVKAGKRVLLANKEALVMSGEIMMQAARDHQALLLPVDSEHNAIFQSLPHNYLQADRTGQPQLGVSKILLTASGGPFLNHSLEQLTHVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFSISEHFVTVVVHPQSIIHSMVQYVDGSTLAQMGNPDMCTPIAHALAWPERLQTNVPALDLFEYSQLNFQAPDTQKFPALNLARQAMRAGGLAPTILNAANEIAVEAFLMERIGFTSIPQVVEHTLEKLENAAAESIECILDKDKVARSVAQQYISSIGG
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: RNPH_RHILW
Sequence: MRPSGRKIDQMRKVSFERNFSKHAEGSCLVKFGDTHVLCTASLEEKTPPWLRNSGKGWVTAEYGMLPRATGERMKREAAAGKQGGRTQEIQRLIGRSLRAVVDLQALGERQITLDCDVIQADGGTRTASITGGWIALYDCLKWMESRNMIKVDRVLKDHVAAISCGVFASQPVIDLDYLEDSSAETDANFVMTGAGGIVEIQGTAEGTPFSEEEFTSLMGLAKNGIGELVALQKQAIAG
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: DTHAD_DELSH
Sequence: MQDTLLTLDTPAAVIDLDRMQRNIARMQQRMDAQGVRLRPHVKTSKSVPVAAAQRAAGASGITVSTLKEAEQFFAAGTTDILYAVSMAPHRLPQALQLRRRGCDLKLIVDSVAAAQAIAAFGREQGEAFEVWIEIDTDGHRSGVGADDTPLLLAIGRTLHDGGMRLGGVLTHAGSSYELDTPEALQALAERERAGCVQAAEALRAAGLPCPVVSVGSTPTALAASRLDGVTEVRAGVYVFFDLVMRNIGVCAAEDVALSVLATVIGHQADKGWAIVDAGWMAMSRDRGTARQKQDFGYGQVCDLQGRVMPGFVLTGANQEHGILARADGAAEADIATRFPLGTRLRILPNHACATGAQFPAYQALAADGSVQTWERLHGW
What is the function of this protein?
Catalyzes the deamination of D-threo-3-hydroxyaspartate (D-THA).  Also exhibits dehydratase activity towards L-threo-3-hydroxyaspartate (L-THA), L-erythro-3-hydroxyaspartate (L-EHA) and D-serine.
What are the official names of this protein?
D-threo-3-hydroxyaspartate dehydratase, D-THA DH, D-THA dehydratase, Threo-3-hydroxy-D-aspartate ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the DSD1 family.
Protein: RAS1_HYDVU
Sequence: MSSSSEPTKFKMVVVGAGGVGKSALTIQLIQNHFVEDYDPTIEDSYIKQVVVDGAICILDILDTAGQEEYSAMREHYMRTGEGFLCIFAVTSLKSFQEIDNFRTQALRVKDADKVPMVLVGNKVDLPKRDVSTKDGNDKALSFGIPYVETSAKTKQGVEEAFFTLVREILADRRNQEGQKKSDSKRAKFKCTLL
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
What are the official names of this protein?
Ras-like protein RAS1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: RM03_YEAST
Sequence: MGIVLKRAIAAGMKPFPNSTWHWSRTIRPFSQHLSSTCFLQQSSRFTSKRYLHLSTLTQQEKRFLPESELAKYKEYYQGLKSTVNEIPESVASKSPSLRTLHKRLQLPNELTYSTLSRCLTCPSAKLPDKINNPTKGAAFVNTVPTNKYLDNHGLNIMGKNLLSYHVTKSIIQKYPRLPTVVLNAAVNAYISEAVLAHIAKYWGIEVETTSVLSRYLKMEPFEFTLGRLKFFNNSLNSKDGIELITGKNFSETSALAMSVRSIIAAIWAVTEQKDSQAVYRFIDDHIMSRKLDITKMFQFEQPTRELAMLCRREGLEKPVSKLVAESGRLSKSPVFIVHVFSGEETLGEGYGSSLKEAKARAATDALMKWYCYEPLAQQEPVIDPGTVVV
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
54S ribosomal protein L3, mitochondrial, Mitochondrial large ribosomal subunit protein mL44, YmL3.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Protein: RL9_MYCBO
Sequence: MKLILTADVDHLGSIGDTVEVKDGYGRNFLLPRGLAIVASRGAQKQADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVAAIKKAGGPNLDKRIVRLPKTHIKAVGTHFVSVHLHPEIDVEVSLDVVAQS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ERPA_PASMU
Sequence: MMTEISVPLIFTDAAANKVKALISEEENPNLKLRVYITGGGCSGFQYGFTFDEKVNDGDLTIEKSGVHLVIDPMSLQYLIGGTVDYTEGLEGSRFVVNNPNASTTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: CYB_DROYA
Sequence: MHKPLRNSHPLFKIANNALVDLPAPINISSWWNFGSLLGLCLIIQILTGLFLAMHYTADVNLAFYSVNHICRDVNYGWLLRTLHANGASFFFICIYLHIGRGIYYGSYLFTPTWLVGVIILFLVMGTAFMGYVLPWGQMSFWGATVITNLLSAIPYLGMDLVQWLWGGFAVDNATLTRFFTFHFILPFIVLAMTMIHLLFLHQTGSNNPIGLNSNIDKIPFHPYFTFKDIVGFIVMIFILISLVLISPNLLGDPDNFIPANPLVTPAHIQPEWYFLFAYAILRSIPNKLGGVIALVLSIAILMILPFYNLSKFRGIQFYPINQILFWSMLVTVILLTWIGARPVEEPYVLIGQILTIIYFLYYLINPLVTKWWDNLLN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FTSW_MARM1
Sequence: MKIQLRDIFEPLSANHMAKVDLWFVMSLIAILALGIVMVASASISVSESIHNTPYFFMGRQILYLILGVSFGFMMLQIPTQNLQKWGILLMLLSLVLLVLVLVPGIGKTVNGSRRWINLIVFNLQASEVAKVCMVVYVSGYLVRRAERVRENLIGFALPLFLTSLFLIFLLMEPDFGASVVLIGTVIALLFIGGAPVYQFIAIVIMAVLVMAGLALSESYRVKRLMNFVDPWADPFNDGYQLSQALIAYGRGEWFGLGLGNSVQKLSYLPEAHTDFVFSIWVEEMGLLGGVVLLSLFALMLSRIFKIGHRALMGARPFAGYMCFGFAILILAQVIINVGVNTGFLPTKGLTLPLISYGGSSLIITLGSLFVVARVDIENKLASKGGESEERKRKSDESIDDGEALA
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: CUL3B_XENLA
Sequence: MSNLGKSTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGAVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA
What is the function of this protein?
Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity).  Involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity).  May play a role in the regulation of mittotic entry via ubiquitination of aurka (By similarity).
What are the official names of this protein?
Cullin-3-B, CUL-3-B.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSAD2_ONCMY
Sequence: MFLQRCMSFLQCIFAAVLAWIGVRGQQVHGASQFSSTGKVNPATIKVVNNVISQASATPSSVNYHFTRQCNYKCGFCFHTAKTSFVLPIEEAKRGLQLLKESGLEKINFSGGEPFIHDRGDFLGKLVQYCKHDLQLPSVSIVSNGSMIREKWFQTYGEYLDILAISCDSFDEDTNQTIGRAQGRKSHLDNLFKVRDWCRKYKVAFKINSVINTFNVDEDMRENITELNPVRWKVFQCLLIDGENAGENSLREAERFLISDQQFQDFLERHSSISCLVPESNQKMRDSYLILDEYMRFLDCREGRKDPSKSILDVGVEEAIQFSGFDEKMFLKRGGKYVWSKADMRLEW
What is the function of this protein?
Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon.
What are the official names of this protein?
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2, SAND, Radical S-adenosyl methionine domain-containing protein 2, Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible, Viperin.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RSAD2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DSBB_SHIBS
Sequence: MLRFLNQCSQGRGAWLLMAFTALALELTALWFQHVMLLKPCVLCIYERCALFGVLGAALIGAIAPKTPLRYVAMVIWLYSAFRGVQLTYEHTMLQLYPSPFATCDFMVRFPEWLPLDKWVPQVFVASGDCAERQWDFLGLEMPQWLLGIFIAYLIVAVLVMISQPFKAKKRDLFGR
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: 6PGL_YERPN
Sequence: MKQAVYVASPDSQQIHVWQLDSAGELTLLQTVDVPGQVQPMAISPNQRHLYVGVRPDFGIVSYHIADDGTLTAAGMAPLPGSPTHIDTDRQGRFLFSASYSFNCVSISPIDTHGVVQAPIQQLDDLPAPHSANIDPTNQILLVPCLKEDKVRLFDLSAEGQLTPHAQADITVAAGAGPRHMAFHPNHQVAYCVNELNSSVDVYQISNNGQEYHLVQSLDAMPADFTGTRWAADIHITPNGRYLYISDRTANLLGIFTVSEDGRVISLVGHHLTEAQPRGFNIDHSGNFLIASGQKSDHIEVYRIDQNTGELTTLKRYPVGKGPMWVSIRGAQNS
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: ENO_MESHJ
Sequence: MSKITKVFAREILDSRGNPTIQVDVYTLAGGFGSAIVPSGASTGSREALELRDTNTKYADNWYGQKGVMTAVDNVNNIIAPEIIGLCCKNQRLIDQKMIELDGTPNKEKLGANAILGVSLAVAKAAANELRMPLFRYLGGTNPTLMPVPMLNVINGGEHASNTLDFQEFMIMPLGFRTFKEALQAANKVFHNLAKLLKKSGFETQVGDEGGFAPNFNSHEQALDFLVDAIKESGFNPGFKGENAVAIAIDAAASEFYNGQKYVFKKLKSASLNKNQADLDEKFEFNSEELLNYYGQLLAKYPIISIEDGFAESDWQGFIAFNQKYGNNHQIVGDDLTVTNVEILKKAINLKAINSILIKLNQIGTLSETLDAIHLAQKSGMTAVISHRSGESEDTTIADLAVAVSSGQIKTGSLSRTDRIAKYNRLLVIEEYLNSYAKADYIGREVFYNLK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: ISPH_ECOLI
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRVDIREVD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis (PubMed:11818558, PubMed:11418107, PubMed:12706830, PubMed:19569147, PubMed:22137895).  In vitro, can also hydrate acetylenes to aldehydes and ketones via anti-Markovnikov/Markovnikov addition (PubMed:22948824).
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase, 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: CC115_HUMAN
Sequence: MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVEEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA
What is the function of this protein?
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis.  In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.  Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633).  May be involved in Golgi homeostasis (PubMed:26833332).
What are the official names of this protein?
Coiled-coil domain-containing protein 115.