PharMolix/UniProtQA huggingface dataset:
Protein: MURD_STAES
Sequence: MLNYTELENKNVLVVGLAKSGYEAAKLLLKLGANVKVNDGKDLSQDAHAKDLESMGIEVISGSHPFSLLDDDPIIVKNPGIPYTVSIIKEATNRGLKILTEVELSYLISEAPIIAVTGTNGKTTVTSLIGDMFQKSVLTGRLSGNIGYVASKVAQEVKSDEYLITELSSFQLLGIEEYKPHIAIITNIYSAHLDYHETLENYQNAKKQIYKNQTKDDYLICNYHQRHLIESENLEAKTFYFSTQQEVDGIYIKDGFIVFNGIRIINTKDLVLPGEHNLENILAAVLASIIAGVPVKAIVDSLVTFSGIDHRLQYIGTNRTNKYYNDSKATNTLATQFALNSFDQPIIWLCGGLDRGNEFDELIPYMENVRVMVVFGETQDKFAKLGNSQGKYVIKATDVEDAVDKIQDIVEPNDVVLLSPACASWDQYHTFEERGEKFIDRFRAHLPSY
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_BRUSU
Sequence: MNKAILAVAMVLLLAGCATKPEEIGRAPDLSPVAAHLGMQNNPQFNGYPARPGKASYSLWDQRSTNFFKDPRAATPGDVLTVIISINDRANLDNKTDRERVSKGIYGGGGSFATSSITGAAAGGDMDASINTHSDSKSKGKGTIERSEDIRLQIAAIVTDTLPNGNLIIRGSQEVRVNNELRVLNVAGVVRPRDISGNNTISYDKIAEARISYGGRGRLSEIQQPPYGQQILDQFSPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: MEBL_ARATH
Sequence: MGSAAELTEPTTGTEKLHQPIEVEEDDEQIVDLERKTFRHGKGHDTSVDSSTITNTSSSSSSSFSGDGGTEETPDFHSNGDGEHTDLVNLEVPELETEIVFHQEHDDGKNCIVFFDGEQGSESAGAIPDAHEESQTADLNGEQTQLEPENGSTSEDNERSREIEEVLDGDVSKDLDAVDPLAGEVIEEEVDFEDVEYHDVENMMDKQETHDLYCPNCDSCITKKVILKRRKRKIRRHELGDSKRPHLTEPLFHSEDNLPSLDGGENSANESFVFKCLSCFTIFIPKGVSSKPIPPRQGVEGLKIQPNPQVEATGDSNWFSSIFGLNKKESAIQQGGASSSVLEANPPPRESIVPVVNPSRGNLSPMRKDTTGSAVVQPDAATSIQVAKSNDTSEIVNNGAIVGDGQKFLAPMVEEQTQQKIDNDDSSTADGNHTSDKGRLSPIQPSHGMSILNTVTNGPDGLKVETTIHEEGAPLLFEGKDTPDTSTADFGLTKVTGVMDTGDRGVITGPANPEIDISAGNLLEEGSLREPLMRRVVVQGRKLEILKSIVYGGLLEAITSLGVISSAAGSGASMLNILVLGLANLLGGLILIIHNLQELREEEPIRTTTEDNQTNGREEEEGRYKRLLGRRENFTLHATVAILSFIITGILPPVVYYFSFSEKHNKDYKVASVFGASLFCIVLLAIAKAHVRYPRGSYLKSILYYGSIAVSVSGISYVVGNFLEQLLEKHGWSDGSETPVGQMMLSSLMGRKAGFGYSSSY
What is the function of this protein?
Not essential for the accumulation of ER body components, including PYK10.
What are the official names of this protein?
Membrane protein of ER body-like protein.
What is the protein family that this protein belongs to?
Belongs to the CCC1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYT_DESVM
Sequence: MNVTIEGQVFDVQSGVSCRDALKGALSGKKFKNVVACRCNGTPLDLTATVPADTTTIEPVFADSPEGIELIRHSAAHIMAEAVQKLFPGVKVTIGPAIDSGFYYDFDYERPFSVDDLEAIEAEMQKIVAAAHPFTRTEMTKDEAVALFEGMGEAYKVEIVRDIPADTVSVYRSGDFVDLCRGPHIPDTSFVKAFKLLSVAGAYWRGDEKNRMLSRVYGTAFADPKALKDHLHQIEEAKRRDHRKLGQQLDLFAFHEDVAPGMVYWHPKGMLLRTILEDFLRKEHLKRGYELVQGPQLLRREVWEKSGHYDNYRENMYFTVIDDNAYGVKPMNCVSHMLIYKSHLRSYRDLPRRMFELGVVHRHEKSGVLHGLLRVRQFTQDDAHILCRPDQLEAEIIGVIALVRDLMGLFGFDYRIVISTRPEKSIGSDEDWDRATNALIGAVATAGLSHTINEGDGAFYGPKIDIKVTDAIGREWQLSTIQVDFTLPDRFDLVYIGQDGERHRPVMVHRAILGSLERFIGVLTEHFAGAFPTWIVPVQARLLTVTDAQNDFAMGARDQLVAAGLRVEADTRNEKLGYKVREAQLEKIPYILVVGDKEVEAGGVNVRLRNGENLGLKTLAEVAEMIRADCQEPFKRGGMSYSFS
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_CLOBL
Sequence: MVMSDPIADLLTRIRNANVVRHEVVEVPSSNIKKAIANIMLTEGYIRDLEEYRDGSVDMLRITMKYGQNKERIITGLKRISKPGLRVYCRKDETPKVLNGLGVAVVSTSKGIVTDREARKLGVGGEVLCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: DAPA_SALPA
Sequence: MFTGSIVALVTPMDEKGNVSRSCLKKLIDYHVANGTSAIVSVGTTGESATLSHDEHGDVVMMTLELADGRIPVIAGTGANATAEAISLTQRFNDSGIVGCLTVTPYYNRPTQEGLFQHFKAIAEHTDLPQILYNVPSRTGCDMLPETVGRLAEIKNIIAIKEATGNLTRVHQIKELVSDDFILLSGDDASALDFMQLGGHGVISVTANVAAREMADMCKLAAEGQFAEARAINQRLMPLHNKLFVEPNPIPVKWACKALGLVATDTLRLPMTPITDHGRDIVKAALQHAGLL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB2_ENCCU
Sequence: MEIRDVETVNRINLHSHIAGLGCDGDEVEYDKDGLVGQIKARKAMAVIRKMVESNKGGKVVLIKGDRGSGKTALAIGLSKSLGGVHFNSISGTEIYSLEMSKSEAITQALRKSVGLRIKESVKVIEGEVVSLSGRRIVLKTVDMESSFEIGEKMRGELDKEKVSAGDVIRIVRERGRVYKIGTSMVKRSDVVGTDTRFVPCPEGELIRITEETQEISLHDIDVVNSKAEGYLALFSGETGEIRAETRDEVNKKVWGWINEGKAEIVRGVLFIDEVHMLDIESFAFLNKAVEEDFCPVILVSTNKGECIVRGTDEPSPYGIPRDFIDRALIISMEKHCRRDLEAILRHRILEEDILIDDDAVDRLVSISEASGLRYSMNLLTISSMRASRRNGRVALGDVERAFELFLDEARGTESFNG
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair.  Also involved in pre-rRNA processing (By similarity).
What are the official names of this protein?
RuvB-like helicase 2.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECA_SYNJB
Sequence: MLQTLQKLLGDPNDRKIRQYRPVVKLINSLEIEIASLSDAELKAKTTEFRQRLDRGESLDDLLPEAFAVVREAAKRVLNLRHYDVQLIGGMVLHEGQIAEMKTGEGKTLVATLPAYLNGLTGKGVHIVTVNGYLARRDSEWMGQVHRFLGLTVGLVQEGMSPEEKRRSYNCDITYCTNSELGFDYLRDNMATDIKEVMQRPFNYCIIDEVDSILIDEARTPLIISGQVARPSEKYLRAAQVARELIRDEHYEVDEKARNVILTDEGFEAAERLLGVSDLFDPKDPWAHFVFNAVKAKELFIKDVHYIVRNQEVVIVDEFTGRVLPGRRWSDGLHQAVEAKEGVPIQSESQTLATITYQNLFLLYPKLSGMTGTARTEEAEFGKTYNLEVTVIPTNRPIRRKDAPDLVYKTERGKWQAVAEEIAHMHAQGRPVLVGTTSVEKSERLSAMLKEMGIPHNLLNAKPENVEREAEIIAQAGRKGAVTIATNMAGRGTDIILGGNAEYMARLKLRERLMPKLAQLDADNPLGSVQMVGRGGGQGFGGTAPKPKKSWTVVSPNFYPCELSARTNQALDEVVAAAVTKYGLNRLPELVVEDLIAVASEKAPVQDPLILQLREVYNSIKAEYEKITEAEHEEVVRLGGLHVIGTERHESRRIDNQLRGRAGRQGDPGSSRFFLSLEDNLLKIFGGERVAKLMDMFRVEEDMPIEHPLLSSSLENAQRKVEVYYFDMRKQVFEYDEVMNNQRRAIYSERRRILEGENLKTKILDYVRKTVGEIVRAHVNPELPPEEWEIDKLTAKMQEFVPLLKQNLKVEDLQDLSYEQILDYLIKQAELAYEAKEAFLDTFEPGLMRKAERFFLLQQVDTLWREHLQQMEALREAVGLRGYGQKDPLIEYKNEGYELFLEMMDNIRRNTVYNLFIFTPQIVQVPQASRPAPAPTAAASPDPSSASGVVEADFTEE
What is the function of this protein?
Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: PSBL_LOLPR
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ATPI_CHAVU
Sequence: MYNLCYIQNLLEYQIAAVEVGQHLYWEIGNFEVHAQVLITSWIVIGLILGLTFLATQNLQFIPTQNQNLIEYILEFIRDLTKSQIGESEYRPWIPFIGTMFLFIFVSNWSGALIPFKLVQLPNGELAAPTNDINTTVALALLTSVAYFYAGLRKKGLSYFGKYIKPTPILLPINILEDFTKPLSLSFRLFGNILADELVVAVLVSLVPLVVPIPMMFLGLFTSAIQALIFATLAAAYIGESIEDHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ARF11_CAEEL
Sequence: MGLFFSKISSFMFPNIECRTLMLGLDGAGKTTILYKLKLNETVNTIPTIGFNVETVTFQKITLTVWDVGGQKKIRALWKYYFPNTTTLVFVVDSSDIERIPEAKEELFSLLAEPELADSHLLVFANKQDMPNARSPAELTQLLDLGSLKNREWFICGTNAHSGQGLYEGLMWVKKQMKT
What is the function of this protein?
Small GTPase involved in protein trafficking between different compartments (By similarity).  Modulates vesicle budding and uncoating within the Golgi complex (By similarity).  In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity).  The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity).
What are the official names of this protein?
ADP-ribosylation factor 1-like 1, ADP-ribosylation factor-like protein 6, ADP-ribosylation factor-related protein 1.1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: SUCC_COXB2
Sequence: MNLHEYQSKHLLKKYNIPVPASEVVFNPDAAVDAAAKIGGDRWVVKAQVHAGGRGKAGGVRLVKNKEELKSAVKALLGMRLVTYQTDERGQPVNQILVEQTSDIARELYLGAVIDRASQRIVFMASTEGGVEIEKVAEKSPEKILKVTVDPAIGLQPFQCRQLFFGLGLQDLKQMRSFTDIVMGLYRLFTERDLSLLEINPLVITGSGELICLDAKINIDDSALYRQSELREMRDTTQEDEHETMAQQWELNYIKLDGNIGCMVNGAGLAMATMDLIKLSGGDPANFLDVGGSATKERVTEAFKIIVSDKNVKGILVNIFGGIVRCDLIADGIISAVKEVGIDVPVVVRLEGNNAQLGAKKLADSGMNIIAAKGFADAAEQIVKQVGVIA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RL14_ANOFW
Sequence: MIQQETRMKVADNSGAREVLVIKVLGGSGRRYANIGDIVVATVKDATPGGVVKKGQVVKAVVVRTKRGVRRTDGSYIRFDENACVIIRDDKSPRGTRIFGPVARELREKDFMKIVSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RSMC_PHOLL
Sequence: MSALTPASEVILRHREQFSSHHLLFAGDIQDTLATQIDAASVRVHTNQYHHWQSLIRTLGESAWFGLVAEKAFTQGCDTLIYYWPKSKQEARFQLRSLFSVLPKGINIFIVGENRSGVRSVDKLMDGMATFRKIDSARRCSLFYGQLEHEVQFEQDNWWNSYQVENVIVNTLPGVFSQDELDVGSRLLLSTFDKPLSGNLLDIACGAGVLAAVLGKKNPELALTLSDVNAAAIASSKATLKANKLEGHVVVSNVYSNIEDKFDWIISNPPFHEGLKTSLLATDDLIRQAPNHLKPGGKLRIVANAFLPYPDLLDKTFGTHEVIAQTGKFKVYQATKKF
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBN_BRUA4
Sequence: MVAACSAYAAVNVATQWAGTRTGIPSVIIAFWQYVIALVLTLPLLVRDGTRALRTSHFGLHVMRVALAAAGVQVWIYALTHVPIWQVVALSMTSPFFVILCARLFLQEKVTPARLLTTFTGFIGALIIIAPWSDSYTVYSLLPILAAALWAGYSVMTKYLTRFEKPASISAYMLVLLTPINAALWLASGLSMSAITAPDVEIWSILIVIGAFTALAQYFQTAAYSIADAVYLQPFDDLRLPINVIFGWIVFAAAPSINFWPGAALIIGASLYLMRQDSGTSRTA
What is the function of this protein?
Transports riboflavin into the cell.
What are the official names of this protein?
Riboflavin transporter.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSLU_LEGPA
Sequence: MVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNILMIGPTGVGKTEIARRLANLAKAPFIKVEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREFAMKKVEHLAEDAAEERILDVLLPPARGTLTPGEKNTTARQVFRKQLREGELNDNEIEIEVAATPVGIEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEEDIKLKAIESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHILFIASGAFHVAKPSDLIAELQGRLPIRVELSALSVEDFVRILTEPSASLTLQYSALMETEGLTLTFDETGIRRIAEVAWQVNERTENIGARRLYTVMERLLEVVSFEATDKAGETVHVDKAYVDKNLGQLIADEDLARYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STOX2_MOUSE
Sequence: MKKTRSTTLRRAWPSSDFSDRASDRMRSRSEKDYRLHKRFPAAFAPQASRGYMTSGDVSPISMSPISQSQFIPLGEILCLAISAMNSARKPVTQEALMEHLTTCFPGVPTPSQEILRHTLNTLVRERKIYPTPDGYFIVTPQTYFITPSLIRTNSKWYHLDERVPDRSQCTSPQPGTITPSASGCVRERTLPRKHCDSCHCCREDVHSMHASTLQRKSAKDCKDPYCPPPLCQVPPTEKSKSTINFSYKTETLSKPKDGEKQSKKFGLKLFRLSFKKDKTKQLANFSAQFPPEEWPLRDEDTPTTIPREVEMEIIRRINPDLTVENVMRHTALMKKLEEEKAHRSKAGSSAHHSGRSKKSRTHRKSHGKSRSHSKTRVSKGDPSDGSHLDIPGEREYEFCDPLTRAPREGCFIIEHKGDNFIMHSNTNVIESHFPMTPEWDVSGELAKRRTEMPFPEPSRGSSHSKVHRSHSHTQDRRSRNERSNKAKERSRSMDNSKGPLGASSLGTPEDLAEGCSQDDQTPSQSYIDDSTLRPAQTIGHQRAHIPSASYKEVCIPEIVGGSKEPSSACSLLEPGKTPESMPSYGELSPCPAKTAVDDYFQCNTSSETVLTAPSPLGKNKEDHDTLTLVEGVKKLSPSERQTPHSSREPVGHKEESPKGPGGGPAASGGVAEGLANGRLVQHHSAEPSSLDKRKEIFSKDTLFKPLHSTLSVNSYHKSSLSLLKSHPKSPVDTLPGRCEKLEPSLGTSAAQAMPPSQRQQEPGGNQEASFDYYNVSDDDDSEEGANKNAEEEKNRDDVGTMQWLLEREKERDLQRKFEKNLTLLTPKETDSSSNQRATHSARLDSMDSSSITVDSGFNSPRTRESLASNTSSIVESNRRQNPALSPAHGGAGPTFNFRASTDPPTSEAEKLQKPSNCLQASVTSV
What are the official names of this protein?
Storkhead-box protein 2.
Protein: PB2_I61A1
Sequence: MERIKELRDLMLQSRTREILTRTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIIETIPERNEQGQTLWSRTSDAGSDRVMVSPLAVTWWNRNGPTASTVHYPKVYRTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLMITKEKKEELQECKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGACWEQLYTPGGEVRNDDVDQSLIIAARSIVRRATVSADPLASLLEMCHSTQIGGVRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSTKKEEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKATRRLVQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMVGILPDLTPSTEMSMRGVRISKMGVDEYSSTERVVVSIDRFLRVRDQQGNVLLSPEEVSETQGTEKLTITYSSSMMWEVNGPESVLVNTYQWIIRNWETVKIQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILIRGNSPVFNYNKGTKRLTVLGKDAGALTENPDEGTTGVESAVLRGFLILGREDRRYGPALSINELSSLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: RL2_ELUMP
Sequence: MPIKTFRPYTPSRRTITVADFSEITTKTPEKRLVKGLRKTGGRNNTGMIMVRHIGGGHKRAYRQIDFKREKYGVPAKVATIEYDPNRNARICLLHYADGDKRYIIHPVGLKIGDEVMSGPNAEIKVGNCLPLKNIPEGTFIHALELKVGKGAQLVRSAGSQAQLMAKENDYAHVKMPSGEIRLVPIACCASIGQVGNVEHNNIVIGNAGRKRHRGVKPTVRGSAMNAVDHPMGGGRGHSKGGNIPRSPWNQPSRGLKTRPKKSWDWMIVSDRRKNKAGK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: Y296_STRPZ
Sequence: MSTAIWILLLIVALGVGVFGGIFIARKQIEKEIGEHPRLTPEAIREMMSQMGQKPSEAKIQQTYRNIIKQSKAAVSKGKK
What are the official names of this protein?
UPF0154 protein Spy49_0296.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: EXGB_ASPFN
Sequence: MKVTRLAVLNTLATLTVAWLPTTDKTITSSNGTDLFKASHGKIRGVNLGSQFVFEPWIATKAWSELGCEGQESEFDCVMKLGQDAANKAFAKHWDSWITKEDIKEIRSYGLNTIRIPVGYWMNEDLIYHDSEYFPHGGFAYLEKLCGWASDAGLYIIIDLHGAPGAQVAKNAFTGQFADTPGFYVDFQYQRALEFLEWMTIKVHTLHNFRNVGMLEVVNEPVQNPQVTTTLRSNYYPNAFHSIRKVEGALSIDRKDYLHIQMMDGAWGAGDPHEHLTDDYYAAYDNHRYLKWDPRVEVSKDSYIKTSCNDNVATNWPAIIGEWSLGVPDNVQETADWKPYSNLDFYQKWFAAQVQNYEQHQGWIFWTWKTQLDEYRWSYRGTYLSGFWQTSS
What is the function of this protein?
Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall.  Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides (By similarity).
What are the official names of this protein?
Probable glucan endo-1,6-beta-glucosidase B, Beta-1,6-glucanase B, Endo-1,6-beta-D-glucanase B, Endo-1,6-beta-glucanase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENTH_ENTCC
Sequence: MIWKRHLSLDALNATSQNTLVAHLGIVYTRLGDDMLEAEMPVDARTHQPFGLLHGGASAALAETLGSMAGFLMTRDGQNVVGTELNATHHRAVAQGTVRGVCQPMHLGRSSQSWEIVVFDEQGRRCCTCRLSTMVLG
What is the function of this protein?
Required for optimal enterobactin synthesis.  Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.
What are the official names of this protein?
Proofreading thioesterase EntH, Enterobactin synthase component H.
What is the protein family that this protein belongs to?
Belongs to the thioesterase PaaI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_HELP2
Sequence: MFGLKQFYQNEVRTKLAQELDIKNPMLLPKLEKIVISVGAGAYAKDMKIMQNIAQTISLIAGQKAVITKAKKSVAGFKIREGMAVGAKVTLRNKRMYNFLEKLIVISLPRVKDFRGISRNGFDGHGNYTFGINEQLIFPEVVYDDIMVSHGMNITMVTSTDNDKEAFKLLELLGLPFAKVR
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: CTTB2_ATEAB
Sequence: MATDGASCEPDFSRSPEDAAGATAEPAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCRKMQERMSTQLAAAESRQKKLEMEKLQLQALEQEHKKLSACLDEERNKNKHVVLMLVKECKQLSGKVIEEAQKLDEVMTKLEEEKKKTTALEEELSAEKQRSTEMEAQMEKQLSEFDTEREQLRAKLHREEAHTADLKEEIDKMKKMIEQLKRGSDSKPGLSLPRKTKDRRLISVSVGTEVSVTKSVACQTDSAIESIEPVKKLPLTVPAKPSTGSPLVSASTKGNMCTNATLVRPGIDRQASHGDLTISSVPAAPTPSASRTEENGPSTGSAPDPTSSTPPLPNNAAPPTVQTPGTAAQSYSQAPPVHSLHSPCANVSLHPGLNPRIQAARFRFQGNANDPDQNGNTSQSPPSRDVSPTSRDNLVAKQLARSTVTQALSRFTSPQTGAPPRPGAAPTGDVSSHTPVSRTSLKTPGVSRVDRGNPPPIPPKKPGLSQTPSPPHPQLKVIMDSSRAASAGVKVDNKTVAVPPSSLPQGNRVISEENLLKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAEPPGLNQPACSESSLVIPNTIAFCSSINPVSASSCRTGASVSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLNAQAQVNAADKNGFTPLCAAAAQGHFKCIELLIANDANINHAADGGQTPLYLACKNGNNECIKLLLGAGSDRSVKTRDGWTPVHAAVDTGNVDNLKLLMYYEAPIPGNSFNEEKLESNIIDLDQEEESPEGIPKTVVPADLINHADREGWTAAHIAASKGFKNCLEILCRHRGLEPERRDKCSRTAHDVATDDCKHLLENLHAFKIPLRISIAEIQPGNHGSDDFECDNIICTLNIRKQTSWDDFSKAVSQALINHFQAVSSDGWWTLEDMTFNNTADSSIGLGASSVQSIMLGNVPWSAGQNFTLFPWEFMRKNKAEQVTVILSGPQEGCLSSVSYTSMIPLQMLQNYLRLVEQYHNVIFHGPEGSLQDYIAHQLALCMKHRQIAAGFTCEIVKAQVHAGFSKEQLVDLFISSACLIPVKQSPVNKKIIIILENLEKSSLSELLGDFLTPLENRSTETPYTLQKGNGMSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFRGQLPSPCDPVCRTVDWALAVWCQLNSCIARLGTPEALLGPKYFLSCPVVPGHAQATVKWMSHLWNAIIAPRVQEAILSRASVKRQHSLGQTTAKKHPSQGQQAIVKAALSILLNKAVLHGCPLQRAELDQHTADFKGGSFPLSMVSSYNSCSRKKAESGAWRKVSTSPRKKSGHFSSPVWNKPDLSEEGIKNKAISQLNYNGSALLAKQKSLENDLSLTLDQRLSLGSDDETDLVKELQNMCSSKSESDISKIADSRDDLRRLHSSGNNPAFSAAVNNPKMPVSQKEVSPLSSHQTTECSNNKSKTELGVSRVRSFLPVPRSKVTQCSQNTKRSSSSSNTRQIEINNNSKEEIWNLRKK
What is the function of this protein?
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
What are the official names of this protein?
Cortactin-binding protein 2, CortBP2.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation.