PharMolix/UniProtQA huggingface dataset:
Protein: AROA_STRA5
Sequence: MKLLTNANTLKGTIRVPGDKSISHRAIIFGSISQGVTRIVDVLRGEDVLSTIEAFKQMGVLIEDDGEIITIYGKGFAGLTQPNNLLDMGNSGTSMRLIAGVLAGQEFEVTMVGDNSLSKRPMDRIALPLSKMGARISGVTNRDLPPLKLQGTKKLKPIFYHLPVASAQVKSALIFAALQTKGESLIVEKEQTRNHTEDMIRQFGGHLDIKDKEIRLNGGQSLVGQDIRVPGDISSAAFWIVAGLIIPNSHIILENVGINETRTGILDVVSKMGGKIKLSSVDNQVKSATLTVDYSHLQATHISGAMIPRLIDELPIIALLATQAQGTTVIADAQELKVKETDRIQVVVESLKQMGADITATADGMIIRGNTPLHAASLDCHGDHRIGMMIAIAALLVKEGEVDLSGEEAINTSYPNFLEHLEGLVNA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSN5A_BRAOL
Sequence: KNILTVEQPDSSSSDGIFYYDEASKRVQISALAL
What is the function of this protein?
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF.  In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins.  It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex.  The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 5a, Signalosome subunit 5a, Jun activation domain-binding homolog 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NAPB_HAEIN
Sequence: MINMTKQVSKILAGLFTALFAGSLMASDAPAVGKDLTQAAENIPPAFHNAPRQGELPALNYVNQPPMVPHSVANYQVTKNVNQCLNCHSPENSRLSGATRISPTHFMDRDGKVGSSSSPRRYFCLQCHVSQANVDPIVPNDFKPMKGYGN
What is the function of this protein?
Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from the membrane-anchored tetraheme c-type NapC protein and transfers these to NapA subunit, thus allowing electron flow between membrane and periplasm.  Essential for periplasmic nitrate reduction with nitrate as the terminal electron acceptor.
What are the official names of this protein?
Periplasmic nitrate reductase, electron transfer subunit, Diheme cytochrome c NapB.
What is the protein family that this protein belongs to?
Belongs to the NapB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PYRB_STAAC
Sequence: MNHLLSMEHLSTDQIYKLIQKASQFKSGERQLPNFEGKYVANLFFENSTRTKCSFEMAELKLGLKTISFETSTSSVSKGESLYDTCKTLESIGCDLLVIRHPFNNYYEKLANINIPIANAGDGSGQHPTQSLLDLMTIYEEYGYFEGLNVLICGDIKNSRVARSNYHSLKALGANVMFNSPNAWIDDSLEAPYVNIDDVIETVDIVMLLRIQHERHGLAEETRFAADDYHQKHGLNEVRYNKLQEHAIVMHPAPVNRGVEIQSDLVEASKSRIFKQMENGVYLRMAVIDELLK
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: LUXS_ECO57
Sequence: MPLLDSFTVDHTRMEAPAVRVAKTMNTPHGDAITVFDLRFCVPNKEVMPERGIHTLEHLFAGFMRNHLNGNGVEIIDISPMGCRTGFYMSLIGTPDEQRVADVWKAAMEDVLKVQDQNQIPELNVYQCGTYQMHSLQEAQDIARSILERDVRINSNEELALPKEKLQELHI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: GGGPS_SULIA
Sequence: MKIRKKKMKLKGKVKKYLMDKLNDNEKLHFSLLDPFKINSSEELKYIAKNLYNVGTDAFLIGGTLGVSKDKLDFVISLLDDYEIPKIIFPSNINLLSEKADALLFLSLLNSDDIYYVIGAQIVAAPIIKMLQMEVIPTAYVIVGHGGTAAHIGKARVIPYDNFELATAYTLAAEYLGMDFVYLEAGSGAPEPIRPEMISFIKKASSIPLIIGGGIRSVEVALKLVEAGANIIVTGNIIERDVDKAIKIIRGIKNK
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).  This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Geranylgeranylglyceryl phosphate synthase, GGGP synthase, GGGPS, (S)-3-O-geranylgeranylglyceryl phosphate synthase, Phosphoglycerol geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP2_HALH5
Sequence: MSIIEAIIIGIVQGITEFLPISSTAHIVITQFLFDYTFPGFGFEIFLHIASILAVILYFRKDLLQVIVGFFSYFKDKSEENRIQFMFAIYIIVATGITGVLGLLLEDLVGAQMKTPPFIAGALIITGTFLIIIERFFVYKDRTVKDMTLKDSIIVGLGQTLAVFPGISRSGATLITALFSGLNKETAVRYSFLLSIPVILGTSVLAIGDLLDGTLVEQVGGLPLIISFIVTFFFSWLGIIWLIDFLKRSKLIYFAFYCFALAIFVFFYFDHNMTIDLE
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 2, Bacitracin resistance protein 2, Undecaprenyl pyrophosphate phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
Protein: ATG3_YEAST
Sequence: MIRSTLSSWREYLTPITHKSTFLTTGQITPEEFVQAGDYLCHMFPTWKWNEESSDISYRDFLPKNKQFLIIRKVPCDKRAEQCVEVEGPDVIMKGFAEDGDEDDVLEYIGSETEHVQSTPAGGTKDSSIDDIDELIQDMEIKEEDENDDTEEFNAKGGLAKDMAQERYYDLYIAYSTSYRVPKMYIVGFNSNGSPLSPEQMFEDISADYRTKTATIEKLPFYKNSVLSVSIHPCKHANVMKILLDKVRVVRQRRRKELQEEQELDGVGDWEDLQDDIDDSLRVDQYLIVFLKFITSVTPSIQHDYTMEGW
What is the function of this protein?
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8.  The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE).  This step is required for the membrane association of ATG8.  The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt).  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 3, Autophagy-related E2-like conjugation enzyme ATG3.
What is the protein family that this protein belongs to?
Belongs to the ATG3 family.
Protein: SECA_SHEB8
Sequence: MFGKLLTKVFGSRNDRTLKGLQKIVISINALEADYEKLTDEALKAKTAEFRERLAAGASLDSIMAEAFATVREASKRVFDMRHFDVQLLGGMVLDSNRIAEMRTGEGKTLTATLPAYLNALTGKGVHVITVNDYLARRDAENNRPLFEFLGLTVGINVAGLGQHEKKAAYNADITYGTNNEFGFDYLRDNMAFSPQERVQRPLHYALIDEVDSILIDEARTPLIISGAAEDSSELYIKINTLIPNLIRQDKEDTEEYVGEGDYSIDEKAKQVHFTERGQEKVENLLIERGMLAEGDSLYSAANISLLHHVNAALRAHTLFERDVDYIVQDNEVIIVDEHTGRTMPGRRWSEGLHQAVEAKEGVHIQNENQTLASITFQNYFRQYEKLAGMTGTADTEAFEFQHIYGLDTVVVPTNRPMVRKDMADLVYLTADEKYQAIIKDIKDCRERGQPVLVGTVSIEQSELLARLMVQEKIPHEVLNAKFHEREAEIVAQAGRTGSVTIATNMAGRGTDIVLGGNWNMEIDELDNPTAEQKAKIKADWQIRHDEVVAAGGLHILGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDSLMRIFASDRVSGMMKKLGMEEGEAIEHPWVSRAIENAQRKVEARNFDIRKQLLEFDDVANDQRQVVYAQRNELMDAESIEDTIQNIQDDVIGAVIDQYIPPQSVEELWDIPGLEQRLHQEFMLKLPIQEWLDKEDDLHEESLRERIITAWGDAYKAKEEMVGAQVLRQFEKAVMLQTLDGLWKEHLAAMDHLRQGIHLRGYAQKNPKQEYKRESFELFQQLLNTLKHDVISVLSKVQVQAQSDVEEMEARRREEDAKIQRDYQHAAAESLVGGGDEHEAVTAQAPMIRDGEKVGRNDPCPCGSGRKYKQCHGKLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: UGPB_BRUSU
Sequence: MFTRLITTSALTGAIALTIGSQAFAQTELAWWHGMTGANNEMVNELSKEFNESQSEYKIVPVYKGNYPETLNAGIAAFRSKQPPAILQVFDAGSGVMMAAEGAIVPAAEVLEKGGYKFDKSQYLPGIVAYYSKPDGTMLSFPYNSSSPILYYNKDAFKKAGLDENKPPKTWPEVFEAAKKIKASGASPCGFTSTWLTWIQTENFAAWNNVPYGTNENGLAGTDVKLEINSPLYVEHFQAIADLAKDGTFRYGGRTSEAKQLFTSGECAMLTESSGGLGDVVKSGINYGIGQLPYYEGHGPQNTIPGGASLWVFAGLSDDQYKGIAEFFNFLSQTKIQVKLHEKSGYLPVTLAAYEETKKSDFYEKNPGRETPILQMMGKEPTENSKGVRLVNLPQVRDILNEEFEAMLGGKQDAKTALDNAVKRGNAAIAAAQ
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Binds G3P.
What are the official names of this protein?
sn-glycerol-3-phosphate-binding periplasmic protein UgpB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PTR13_ARATH
Sequence: MGVVENRKILPEKKLGGWRAITFILGNETLEKLGSIGVSANFMLYLRNVFHMEPVEAFNVYYLWMGLTNFAPLLGALISDAYIGRFKTIAYASLFSILGLMTVTLTACLPQLHPPPCNNPHPDECDDPNKLQLGILFLGLGFLSIGSGGIRPCSIPFGVDQFDQRTEQGLKGVASFFNWYYLTLTMVLIFSHTVVVYLQTVSWVIGFSIPTSLMACAVVLFFVGMRFYVYVKPEGSVFSGIARVIVAARKKRDLKISLVDDGTEEYYEPPVKPGVLSKLPLTDQFKFLDKAAVILDGDLTSEGVPANKWRLCSIQEVEEVKCLIRVVPVWSAGIISIVAMTTQATFMVFQATKMDRHMGPHFEIPAASITVISYITIGIWVPIYEHLLVPFLWRMRKFRVTLLQRMGIGIVFAILSMFTAGFVEGVRRTRATEMTQMSVFWLALPLILMGLCESFNFIGLIEFFNSQFPEHMRSIANSLFPLSFAAANYLSSLLVTTVHKVSGTKDHPDWLNKDLDRGKLDYFYYLIAVLGVVNLVYFWYCAHRYQYKAGSQIEDFNEEKSLLDIEPNQRHDQSPS
What is the function of this protein?
Low-affinity proton-dependent nitrate transporter.  Not involved in dipeptides transport.  Involved in delivering nitrate for seed development.
What are the official names of this protein?
Protein NRT1/ PTR FAMILY 2.12, AtNPF2.12, Nitrate transporter 1.6.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GRAS_STAAS
Sequence: MNNLKWVAYFLKSRMNWIFWILFLNLLMLGISLIDYDFPIDSLFYIVSLNLSLTMIFLILTYFKEVKLYKHFDKDKEIEEIKHKDLAETPFQRHTVDYLYRQISAHKEKVVEQQLQLNMHEQTITEFVHDIKTPVTAMKLLIDQEKNQERKQALLYEWSRINSMLDTQLYITRLESQRKDMYFDYVSLKRMVIDEIQLTRHISQVKGIGFDVDFKVDDYVYTDIKWCRMIIRQILSNALKYSENFNIEIGTELNDQHVSLYIKDYGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYLVNSVKDQLGIHLQVTSTVGKGTTVRLIFPLQNEIVERMSEVTNLSF
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).  Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX.  In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis.  Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis.
What are the official names of this protein?
Sensor protein kinase GraS, Glycopeptide resistance-associated protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AQP8_MILTA
Sequence: MSTAESRNHYKEVPTIEHYSEAIGITNRKKMDWRGWLRKSTLVRSQLIRGCMAEFLAVFVLMVFIEGSAATAIFTNRRQDILFGSISSGLGVAMAVYVAGGVSGAFLNPAVALAFAVLGKLSWKNCIFYMISQYLAAFVASCTMFAYLYEALNNFDGGERQMFGPNGTAHIWSTYPQPFLSPHTAFADQVFCTAILLIVVLAMCDSKNWKPHNGFLPIAIGLLIITISCTLSYNAGAAMNPSRDLAPRFFSYLAGYGTEPFGVKGYTWFFVPVLGSHCGAIIGGAIYQLFIGGQWPDDTSDTNSVSSMSYNEDNSTLTKRKQVSNIVHDSKGAKGSSTAPVN
What is the function of this protein?
Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis (PubMed:23761966).
What are the official names of this protein?
Aquaporin-8, AQP-8.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL13_CROS8
Sequence: MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNAEKVAVTGNKRSDKMYYHHTGHIGGIKEATFEEMIARRPERVIEIAVKGMLPKGPLGRAMYRKLKVYAGNEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: STX13_LYCMC
Sequence: MLKFILTCTSVILFTAVEDSSCGKGGNYPISVYESYYGCKLKLDDGYCKNICGLHGVSYGYCYASYCWCEKLSDRNVRYWDYHRNNCKNDLLYP
What are the official names of this protein?
Neurotoxin 213.
What is the protein family that this protein belongs to?
Belongs to the long (3 C-C) scorpion toxin superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS19_AERPE
Sequence: MAFEMRPEWKKFRYRGRTLEELLKMDIEELARLFPARQRRSLLRGLTPAQQKLLLKVRKIRRRLEEGRLKRPPVIRTHVRDMVILPEMVGLTIAVYNGKEFIPVKIVPEMIGHYLGEFSPTTRIVQHGEPGLKATRSSLHVASK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: RIMM_STRT2
Sequence: MTYYNVGKIVNTQGLQGELRVLSVTDFADERFKKKSVLALFDDKDNYIMDVEVASHRKHKNFDIVKFKGLYHINDVEKYKGCSLKIAEENLTDLDDGEFYYHEIIGLDVYEGNTLIGQVKEILQPGANDVWVVKRKGKKDLLLPYIPPVVLDVDVAAGRIEVELMEGLDDED
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBT_MICAN
Sequence: MESVAYILVLTMALSVIFFAIAFREPPRIQK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: ELP3_DEHMC
Sequence: MKKLSRTISGVTPVAVMTKPLPCPGKCIYCPTFAATPQSYTPESPAVLRAKSCEYQAYKQVALRLRIIQDMGHPTDKVELIIMGGTFLSADITYQYGFIKDCYDALNGVVAGSLEEAKTINETAQHRCVGLCIETRPDICGKAEIQRMIDFGTTRVELGVQMLDDDIYKLVERGHRVSDVAEATCLLREYGLKVHYHWMPGLPGSSPEKDLALSRMVFEDPRFCPDGLKLYPTMVVEGTILEQWWKEGRYTPYPNGTMTGLIADIKALVPPYVRISRVLRDIPAVFISAGLKDSLRDGVRQILESRHQKCRCIRCREYGHRQRKGQTSGEPTLRRLDYPASGGKEIFLSFEDASDTLYGLLRLRIPCASLPVLGQKYGAKTGLVRELHVYGTELSLGEQGDQSAQHRGLGRKLLAEAECLARDEFGLDSLAILSGVGAREYYRSLGYELVAGYMCKHLD
What is the function of this protein?
tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:27455459).  The proposed mechanism is the following: (i) recruits S-adenosyl-L-methionine and cleaves it to generate a 5'-deoxyadenosine radical (5'-dA) in the radical S-adenosyl-L-methionine (rSAM) region, (ii) hydrolyzes acetyl-CoA in the N-acetyltransferase domain and (iii) an acetyl radical is formed by the products of the two domains and (iv) is transferred onto the C5 position of uridine(34) in the bound tRNA molecule.  Does not show protein lysine acetyltransferase activity (By similarity).
What are the official names of this protein?
tRNA uridine(34) acetyltransferase, Elongator complex protein 3 homolog, DmcElp3.
What is the protein family that this protein belongs to?
Belongs to the ELP3 family.
Protein: RSMG_EXISA
Sequence: MNESQFIEALRAEGFELSETQLSQFKRYFEMLVEWNEKMNLTAITDREEVYLKHFYDSLSAAFHFDFTKVETVCDVGAGAGFPSLPLKILFPHLHVTIIDSLNKRITFLNELALALGLEGVAFHHGRAEEFGKNKKFREQFDVVTARAVARMTVLAEYCLPLAKVGGSFVALKAAKVSDEMADAKNALAVLGGKEKATHQFLLPGEMSERNIVVVDKLRKTPGKYPRKAGTPAKEPLI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 535 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTUD4_MOUSE
Sequence: MEAAVGAPDGVDQGGVGPLEDETPMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEVRMACIRYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFVIYQEPNVSPSHVTENNFPEKVLLCFSNGNHYDIVYPITYKDSSAMCQSLLYELLYEKVFKTDVSKIMMGLEASEVAEESNSEISDSEDDSCKSKSTAATDVNGFKPSGSENPKNNGNSADLPLSRKVLKSLNPAVYRNVEYEIWLKSKQAQQKRDYSIAAGLQYEVGDKCHQVRLDHNGKLSNADIHGVHSENGLVLSEELGKKHTPKNLKPPPPESWNTVSGKKMKKPNSGQNFHSDTDYRGPKNLNKPIKAPSALPPRLQHPSSGVRQHAFSSHSTGSQSQKSSSEHKNLSRMPSQITRKPDRERAEDFDHVSRESYYFGLSPEERREKQAIEESRLLYEIQNRDEQAFPALSSSSVSQSPSQNSNACVPRKSSHARDRKGSMRRADAEERKDKDSLRGHTHVDKKPEPSTLEISDDKCTRVSSPSKSKKECPSPVEQKPAEHIPLSNPAPLLVSPEVHLTPAVPSLPATVPAWPSEPTTFGPTGVPAQIPILSVTQTTGPDAAVSQAHLTPSPVPVSIQAVNQPLMPLPQTMSLYQDPLYPGFPCSEKGDRAIAPPYSLCQTGEDLPKDKNILRFFFNLGVKAYSCPMWAPHSYLYPLHQAYMAACRMYPKVPVPVYPQNTWFQEAPPAQSESDCPCTDAHYSLHPEASVNGQMPQAEMGPPAFASPLVIPPSQVSEGHGQLSYQPELESENPGQLLHAEYEESLSGKNMYPQQSFGPNPFLGPVPIAPPFFPHVWYGYPFQGFVENPVMRQNIVLPPDDKGELDLPLENLDLSKECDSVSAVDEFPDARVEGAHSLSAASVSSKHEGRVEQSSQTRKADIDLASGSSAVEGKGHPPTQILNREREPGSAEPEPKRTIQSLKEKPEKVKDPKTAADVVSPGANSVDRLQRPKEESSEDENEVSNILRSGRSKQFYNQTYGSRKYKSDWGSSGRGGYQHVRGEESWKGQPNRSRDEGYQYHRHVRGRPYRGDRRRSGMGDGHRGQHT
What is the function of this protein?
Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein.  May negatively regulate inflammatory and pathogen recognition signaling in innate immune response.  Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066).  Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes.  Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity).
What are the official names of this protein?
OTU domain-containing protein 4.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Primarily cytoplasmic.
Protein: SPD2_CAEBR
Sequence: MNEDAPMDLVDDRFADQSIQDEPVDDGESFYNEDVYVDCEEDEDDDVVPTSENFRLENRYKPSLHTPRELPTIREENREDVRSNTSSRVNTRPPSVLSDKSNDISNMFGFQDGGRAIDQYTDQFYSEGNRAERLFPEAGFLQNSPVRDKQNSWEPSVCHYEKQPTPEVKNNSPGLVFANMSSKKDVTRKQENVRPGKMMPEKVNDENEPKSRRFSPERNTFTTSPMNSTKYLEEKTSTPKRPGGTNRLGTRGLPSFECSTIYDISPQRTSGTPKTYESRHPTNAYTPNSATTSDTVLSNRTIGDNTVQNVLKGVDINLLTALENARKKRDRPQVKPDFRLNSLPRGKLSSTQRPKSDDHSSMTSIVSSSTQNNTGYRKIQEQRNSATSTDLTNSNTSNFTNNTSRVSTAKNDFSRSSRQRNGFSDSSVSTIIPNMNSMTTRDRDGRDSVSSVRTISRASSTMTVGGGNGHMTSGAPKPLRFHVSRLGFGYVPIGETLTMQLEVENTTDRPCKVNARLDSKITCFKVLDNATTMIDPKKAIKVRVAFTPTSLGRYSLYLKAEVAEQNFTQKIPVWGWGGVSKIAPISARNLQPTSNSSEFAMFVSDMKRIAFKLGNSGDRSGFALLTVYDSAMRQVPNSYVRFNPSNGIVIGKNYEKLIEIRIDPSYHDHYGELTNNRTSSAMSTVSTASSMASLRRRVIAGSDFFVQVAWGVEGIRERLRMLEMKHKRRQMIDGLDFTSHPFTDEKCVVYPPPDAYPTISDEDHDLFAASYSNFYINIFSSPDGLNAFRAATVSADKFDNDATVLETSAFRHQTFVNDVTMVPRHTKLM
What is the function of this protein?
Required both for centrosome duplication and maturation.  Required for pericentriolar material (PCM) recruitment.
What are the official names of this protein?
Spindle-defective protein 2.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Component of the centrosome. Localizes to the centriole throughout the cell cycle and accumulates on the PCM during mitosis (By similarity). Recruitment to the centrosome during prophase of the 1- cell embryo is regulated by the cye-1/cdk-2 complex.
Protein: HIS7_BIFLS
Sequence: MARTAHIVRETSESHIDLELNLDGTGKTDIDTSVPFYNHMMTALGKHSLIDLTIHAHGDTDIDVHHTVEDTAIVFGEALKQALGDKKGIRRFADATVPLDEALAKAVVDISGRPYCVCSGEPEGYEFCMIGGHFTGSLVRHVMESIAFHAGICLHMQVLAGRDPHHIAEAEFKALARALRFAMEIDPRVDGVPSTKGAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_BRUMB
Sequence: MLMFLTHFAEHVTPFNVFRYITFRTGGAMITSALIVFLFGPTIINSLRVRQGKGQPIRADGPQTHFKKAGTPTMGGLMIMTGILASCLLWANLASVYVWVVLMVSVGFGAIGFYDDYLKVTKQSDKGFSGKARLGIEFLIAAIAAFTIMRAGQEPFSSSLTFPFVKQLVINLSWFFIPFAAFVMVGAGNAVNLTDGLDGLAIVPVMVAAASFGFIAYLSGNAIFADYLQIHFVPGTGELAVVLGAVIGAGLGFLWFNAPPAAIFMGDTGSLALGGMLGTVAVATKHEIVLAIIGGLFVMEALSVIIQVGFFKMTGRRVFLMAPIHHHFEKKGWTESQVVIRFWIVAIILAMIGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.