PharMolix/UniProtQA huggingface dataset:
Protein: PYCC_RHOS2
Sequence: MSINDDISSDVMRIRDADWNKRSGSKVPSPGDVTLSNGAVEIDATYLYADMANSSRMAKELDRRVTAKILKSFLASSSRLISHFGGTIMSFDGDRVMGAFMGDAKNSSAIKCSFSIAYSVTQLIRPKFESKYDTVKNAGFKIRHATGVDTGTVFVVRGGIYGSNELISIGRAPNLAAKLSDLREGEYTTFATKSVYDRTNKLQKQRLDGSSDIWEKRDWDFCDENITIYRSSYWRKPGSN
What is the function of this protein?
The pyrimidine cyclase gene of a two-gene Pycsar system, weakly generates cyclic UMP (cUMP) from UTP, has little to no activity on ATP, CTP or GTP (PubMed:34644530).  Expression of this and adjacent effector RsmPycTM (AC A0A1V0HUU2) probably confers resistance to bacteriophage.  The genes are probably only expressed in response to bacteriophage infection (Probable).
What are the official names of this protein?
Uridylate cyclase, Cyclic UMP synthase, cUMP synthase, RsmPycC.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Pyrimidine cyclase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_LISIN
Sequence: MTKYIFVTGGVVSSIGKGITAASLGRLLKNRGLSVTIQKFDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKVYSEVIKKERRGDYLGGTVQVIPHITNELKDRVFRAARMTNSDIIITEIGGTVGDIESLPFLEAIRQIKSDVGAENVLYIHTTLIPYIKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEQPVSQEMKDKIALFCDIKASEVIESRDEETLYNVPLSLQKQKMDDIVLEHLQLEAPQAEMTDWKNLVHRVKNLSKKVRIGLVGKYVSLQDAYLSVAEALRHAGYEHDAEIEIDWIDSEKVTKENVAEIMKDVDGILVPGGFGDRAIEGKIAAIEYARVNKVPYFGICLGMQLATVEFARNVLGLEGAHSAEIEPETKHNIIDLLPEQKNIENMGGTLRLGLYPARIKQGTKAEAAYGTTLVEERHRHRYEFNNEYREQMEEAGMIVSATSPDGRLVEVVELADHPWFVACQYHPEFISRPNRPQSLFKDFVGAALNNK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: HSLV_COXBN
Sequence: MEQFRGTTILSVRRNGKVVIGGDGQVSMGSTIMKANARKVRRLYNGKVIAGFAGGTADAFTLFERFESKLEKHSGNLTRAAVELAKDWRTDRILRRLEALLTVADSKASLIITGLGDVIEPEQSLMAIGSGGSFAQAAAKALLENTKLSARKIVEKALTIAADICIYTNQNFTIEELDSES
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG13_YEAST
Sequence: MVAEEDIEKQVLQLIDSFFLKTTLLICSTESSRYQSSTENIFLFDDTWFEDHSELVSELPEIISKWSHYDGRKELPPLVVETYLDLRQLNSSHLVRLKDHEGHLWNVCKGTKKQEIVMERWLIELDNSSPTFKSYSEDETDVNELSKQLVLLFRYLLTLIQLLPTTELYQLLIKSYNGPQNEGSSNPITSTGPLVSIRTCVLDGSKPILSKGRIGLSKPIINTYSNALNESNLPAHLDQKKITPVWTKFGLLRVSVSYRRDWKFEINNTNDELFSARHASVSHNSQGPQNQPEQEGQSDQDIGKRQPQFQQQQQPQQQQQQQQQQQRQHQVQTQQQRQIPDRRSLSLSPCTRANSFEPQSWQKKVYPISRPVQPFKVGSIGSQSASRNPSNSSFFNQPPVHRPSMSSNYGPQMNIEGTSVGSTSKYSSSFGNIRRHSSVKTTENAEKVSKAVKSPLQPQESQEDLMDFVKLLEEKPDLTIKKTSGNNPPNINISDSLIRYQNLKPSNDLLSEDLSVSLSMDPNHTYHRGRSDSHSPLPSISPSMHYGSLNSRMSQGANASHLIARGGGNSSTSALNSRRNSLDKSSNKQGMSGLPPIFGGESTSYHHDNKIQKYNQLGVEEDDDDENDRLLNQMGNSATKFKSSISPRSIDSISSSFIKSRIPIRQPYHYSQPTTAPFQAQAKFHKPANKLIDNGNRSNSNNNNHNGNDAVGVMHNDEDDQDDDLVFFMSDMNLSKEG
What is the function of this protein?
Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (PubMed:10995454, PubMed:11086004, PubMed:15743910, PubMed:17295840, PubMed:18077553, PubMed:18287526, PubMed:19805182, PubMed:19995911, PubMed:20647741, PubMed:20855505, PubMed:22447937, PubMed:22778255, PubMed:22782902, PubMed:22885598, PubMed:8224160, PubMed:21468027).  Required for autophosphorylation of ATG1 at 'Thr-226' and its dimerization (PubMed:20439775, PubMed:17699586, PubMed:21712380).  May also be involved in the regulation of autophagy through SNF1 (PubMed:11486014).  Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure (PubMed:14723849, PubMed:17426440).  Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (PubMed:10837477).  Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (PubMed:10837477).  Finally, ATG13 is also required for glycogen storage during stationary phase (PubMed:11486014).
What are the official names of this protein?
Autophagy-related protein 13.
What is the protein family that this protein belongs to?
Belongs to the ATG13 family. Fungi subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: ALLA_BRUSU
Sequence: MQIETLTVEPLTKEAFAPFGDVIEVEGAQLRLINNGTTERYHDLARVEAAGTQTRVLINIFRGQSFAAPIDIMMMERHPFGSQAFIPLNGRPFLVVVAEDAGAGPARPRAFLARGDQGVNYLRNIWHHPLLALEQKSDFLVVDRAGREDNLEEYFFSDYAYRIETTQTA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: GEM1_ASPOR
Sequence: MATVRICVCGDEGTGKSSLITSLVKGVFVTNKIQPILPQITIPPTIGTPENVTTTTVVDTSALPQERSNLAREIRKSNVILLVYSDHYSYERVALFWLPYFRSLGVNVPVVLCANKSDLAADHSEAQVIEEEMLPLMAEFKEIDSCIRTSAREHRNVNEAFFLCQKAVTHPIAPLFDSKESALKPAAVAALQRIFYLSDKDRDGYLSDKELEDFQMRCFEKPLSEEDLVHIKETIQKTHPTSVAPSGIDCRGFIHLNKMYAEKGRHETVWIILRAFQYTDNLSLQESFLHPRFEVPPYASAELSPEGYRFFVNLFLLSDKDNDGGLNDAELASLFAPTPGLPASWADGSFPSSTVRNEAGHVTLQGWLAQWSMTTFTSPKTTLEYLAYLGFESSDRSNPSTTAALKVTRPRKRRKRPGRVGRNVVLGHVLGPPGSGKSALLDAFLARGFSTTYHPTIQPRTAVNTVELPGGKQCYLILDELGELEPAILENQVKLLDQCDVIVYTYDSSDPDSFAYIPELRSKYPHLEELPSVFVALKADLDRTTQRAEYQPHEYTAMLNMPSSPLHVSVTWSSMQEVFVHIAEAAMEPSTAFPRSEEDVEGKWMAWGIALGAVVCAGAAAVMIWRRVSGSGT
What is the function of this protein?
Mitochondrial GTPase involved in mitochondrial trafficking.  Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
What are the official names of this protein?
Mitochondrial Rho GTPase 1, GTPase EF-hand protein of mitochondria 1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial Rho GTPase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Protein: TUSC_SALA4
Sequence: MKRIAFVFSTAPHGSASGREGLDALLATSALTEALGVFFISDGVFQLLPGQKPDAVLARDYIATFKLFDLYDIDQCWICAASLRERGLENVNFVVDATPLEPVALRRELGNYDVILRF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO11_METTH
Sequence: MEVILDKRNEMEIVFEGETHTLCNVLRSILMEDEKVKAAAYSIDHPIVGEPQLYIRAGSPKKSLKAAAETLRDRCDEFRRLIESL
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit L.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BBX23_ARATH
Sequence: MKIQCEVCEKAEAEVLCCSDEAVLCKPCDIKVHEANKLFQRHHRVALQKDAASATTASGAPLCDICQERKGYFFCLEDRAMLCNDCDEAIHTCNSHQRFLLSGVQVSDQSLTENSECSTSFSSETYQIQSKVSLNSQYSSEETEAGNSGEIVHKNPSVILSP
What is the function of this protein?
Probable transcription factor that may be involved in seedling photomorphogenesis.
What are the official names of this protein?
B-box zinc finger protein 23, Protein DOUBLE B-BOX 4, Protein SALT TOLERANCE HOMOLOG 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: RF2_CHLTR
Sequence: MHENFDKRLELLLEGLALTRRSLFDPEGKENELKELEQQAVQDGFWDDVVRAGKISERIARLKQQLSEFNELKNKVSAIQFFLEDEESSKDLEMQKELEKEFVFCEKKITEWETLRLLSGELDRNSCFLSINAGAGGTESCDWVEMLLRMYMRWASSHSWRIEVIDRLDGEVAGIKHITLKLVGEYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQNREACMNMLRARIYQKLLQERLEKQNIDRKNKKEISWGSQIRNYVFQPYTLVKDVRTGYEVGNIQAMMDGELLDAFIKAYLVDYGEIT
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSUG_MYCAP
Sequence: MNIVFSKEVESALKHKRPVVALESTIITHGMPYPKNVEMALNVENIIRKQGAVPATIAIINGIIHVGLENDEINELAKLKDVIKTSKRDFGYVLANKKNGGTTVSGTVLVAQKVGIPVFATGGIGGVHRGAEITFDISRDLDELSTNNVLVVCAGAKLILDLGLTLEYLETKGVEVLGYNSDKLPAFYSSSSEFNVTYNVHSASEVAAIMKAKWKFTNGGIILANPIPEQYGLEYEYILDNINKAIEQAKVEGISGKKTTPYLLSKVLELTEGKSLEANIQLVYNNAKVAAQVAVEYAKQK
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: LPXH_XANCP
Sequence: MTTLFISDLHLDPARPAITELFLDFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVAEALHAVATTGVPVFFMPGNRDFLVGAAYAQRAGFRILPDPTVIDLYGQPTLLMHGDLLCTDDTAYQAFRAQTRDPAFQAQFLSQPLAARVAFAQQARAASHARQSELKQGDQAQFETVTDVAPAEVDATFVRYGLDRIIHGHTHRPAIHTVQAGGRTCTRVVLGDWYEQGSVLRVDADGLALEQLAL
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GABT_PIG
Sequence: MASVLLTRRLACSFRHNHRLLVPGWRHISQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
What is the function of this protein?
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively.  Can also convert delta-aminovalerate and beta-alanine.
What are the official names of this protein?
4-aminobutyrate aminotransferase, mitochondrial, (S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase, GABA-AT, Gamma-amino-N-butyrate transaminase, GABA transaminase, GABA-T, L-AIBAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RL29_ECO7I
Sequence: MKAKELREKSVEELNTELLNLLREQFNLRMQAASGQLQQSHLLKQVRRDVARVKTLLNEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: ISCU_BUCAP
Sequence: MAYSKKVMDHYENPRNVGSFSNSDSNVGSGLVGAPACGDVMKLQIKVNEQGIIEDACFKTYGCGSAIASSSLVTEWIKGKSITEAEAIKNTSIVEELELPPVKIHCSILAEDAIKAAISDYKSKKNKN
What is the function of this protein?
A scaffold on which IscS assembles Fe-S clusters.  Subsequently gives the nascent cluster to other proteins.  It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity).
What are the official names of this protein?
Iron-sulfur cluster assembly scaffold protein IscU, Sulfur acceptor protein IscU.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
Protein: HIS6_BLOFL
Sequence: MLAKRIIPCLDVINNQVIKGIQFQNHQIIGDIVSLAQYYSQEGADELVFYDIMASPNNQTVSKKWVAKIAEVINIPFCVAGGISTLYQAKEILKFGADKISINSPALLNPSLIQKLADHLGTQCVVVGIDAWYNAQLGTYQIKCFSGNSSRMQSTTWELLDWVIQIQQYGAGEIVLNMMNQDGMQNGYDLKQLSKIRKHCTIPLIASGGAGTAQHFLDVFQYADVDGALAASVFHKKIIKINELKNFLIKQGVEIRLC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_PROM1
Sequence: MARVKRGNVARKRRNKILRLARGFRGGNGTLFRTANQRVMKALCNAYRDRRRRKRDFRRLWIARINAAARLNGLSYSKFMGGLKKADIRINRKMLAQLAVIDPKTFTNVAVNSKS
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: CM3A_CONTU
Sequence: RHGCCKGPKGCSSRECRPQHCC
What is the function of this protein?
Mu-conotoxins block voltage-gated sodium channels (Nav).  This synthetic toxin reversibly and potently blocks rNav1. 4/SCN4A (IC(50) is 9 nM) and rNav1. 2/SCN2A (IC(50) is 40 nM).  It also moderately blocks rNav1. 1/SCN1A, rNav1. 3/SCN3A, and rNav1. 6/SCN8A.  The block of SCN1A and SCN2A is modified when beta-subunits are coexpressed with alpha subunits.  Hence, blocks of channels containing beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing beta-2 and beta-4 subunits are less potent (compared to channels without beta subunits).
What are the official names of this protein?
Mu-conotoxin TIIIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: IPI1_EMENI
Sequence: MGASTKRKKEKQKDFQKPKLKVGKAKAKPDNFTDTSFKSKAITLNQQSLTLTAPSANTQFSHHLSLLSSKSDSQRRDSLAHLTTTLTSQPTHLPPPQPVSVILPSLLPLILDSNASVRANLLKLLRALPQHDVKDHVGTLMPYIRAGMTHLAAEVRVSSVEVLGWLVSIAGDEVVGVAGGWVKTLNCFLSVLGWHVAAKSKWTSLATSTSTSASGSGNGTGSSTSGKASYGKAGAKGRPQVRFLTILADFLDAGIGSSGSQSMDTTADSASESENQYCTFPITTFASHLIPSNFASPYLTLNLFGTPRDEEGEMYETREDRWRVFVARGFLGAVERGLETARGEGGEVGRVSALAAKVLRNARDDLEGDGFGDEL
What is the function of this protein?
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
What are the official names of this protein?
Pre-rRNA-processing protein ipi1.
What is the protein family that this protein belongs to?
Belongs to the IPI1/TEX10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIAB_BURMS
Sequence: MTKKVYVKTFGCQMNEYDSDKMVDVLNAAEGLEKTDTPEDADIILFNTCSVREKAQEKVFSDLGRVRELKEAKPDLLIGVGGCVASQEGASIVARAPYVDLVFGPQTLHRLPQMIDARRESGRAQVDITFPEIEKFDHLPPARVEGPSAFVSIMEGCSKYCSYCVVPYTRGDEVSRPLDDVLTEVAGLADQGVREVTLLGQNVNAYRGAIAAGSAEIADFATLIEYVADIPGIERIRYTTSHPKEFTQRLLDVYAKVPKLVDHLHLPVQHGSDRILMAMKRGYTVLEYKSVIRKLRAIRPNLSLSTDIIVGFPGETDADFDKTMALVHEMSYDTSFSFIYSPRPGTPAANLADDTPRELKLKRLQHLQATIEENVARISQSMLGKVERILVEGPSRKDPNELAGRTENNRVVNFPAPSAAHPRLIGQMIDVKINHAYPHSLRGELVLAHGDASAATH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_RICCN
Sequence: MNNQGRSILAWATLFIFVILLFNVFQSDSLLGGRNNITFSDFLTRVDEKTVNSVKIQGRVIEGTSNDGSTFNTYAPDYPDLVNRLTSNDVNIEVVPLETRMNTFLGFLISWFPMLLLIGVWVFFMRQMHGGGKAMGFGKSKARLLSDKGPKITFKDVAGIDEAKEELTEIVDFLRDPSKFQKLGGKIPKGCLLIGPPGTGKTLLAKAIAGEANVPFFSISGSDFVEMFVGVGASRVRDMFEQGKRNAPCIIFIDEIDAVGRHRGIGMGGGNDEREQTLNQMLVEMDGFEANEGVVIIAATNRPDVLDRALLRPGRFDRQIAVANPDINGREQILKVHLKKIKYNSTVLARIIARGTPGFSGAELANLVNEAALIAARLGKKEVDMHDMEEAKDKVLMGVARRSIAMSEKEKRLTAYHEGGHALVGLYCPAASPIHKATIIPRGNALGMVQRLPETDEYSQNREQMESSIAVYMAGRVAEEIIFGRNKVTSGASSDIKGATNIARAMVTKAGLSDLIGPIFHGSSGDDMYGRQPNNETSEATAELIDAEVKRIITQGYEFAKDILTKHIDQLHTLANALIEYETLSGQQIKNLLSGRALDSEEENKFPFNDSSTIKIDKEKSPEKTKTTKAKKENYAS
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: NADK_SOLUE
Sequence: MPIIKTAGIISKPNSTAAEEIVPKLIEWLRRRGIAVRIDEQTSLYSGGVSGMPREEVPQSCDLVVVLGGDGTLLSAARAIGRREIPLFPVNLGGLGFLTAISIEELYPELERALRGEHRIAKRKLMTTEVIRENNVIASFDALNDAVLTKSSIARMIDLDTYVDEQFVCAYKADGLIIATPTGSTAYSLSAGGPIIFPSVPAICLTPICPHMLTNRPVLVPETSVIRVASRGPDESVYLTIDGQVGTPIREHDTVVCHSSHHSLLLIRPPRMMFFDVLRQKLKWGER
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_SHEDO
Sequence: MPIITLPDGSKREFVNPVSTLDVAADIGPGLAKACIAGRVNGELKDACDLISTDSDLSIITAKDQEGVEILRHSCAHLLGHAVKQMWPEAKMAIGPVIDNGFYYDIDLDHKLTAEDIEALEKRMMDLAKTNYDVVKRVVSWHEARDAFSERGEVYKIAILDENISKDATPALYHHEEYTDMCRGPHVPNMRFCQNFKLMSVAGAYWRGNSDNKMLQRVYGTAWADKKALKTHLTRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSLFLELEKFIRQKLGQYTYQEVKGPLMMDRALWERSGHWDKYSDAMFTTNSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTDDQVQKEVSDCIQMVYDTYATFGFENIVVKLSTRPEKRIGDDDMWDRAEEALKQALIANEIEFEILPGEGAFYGPKIEFTLHDCLDRAWQCGTVQLDYALPSRLGATYVAEDNTRQTPVMIHRAILGSLERFLGILIEEYAGKFPTWLAPMQVVVMNITDKQADYVQDVVKIFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENKEVAVRTRDGIDLGKMSIEDFAKKIHKDISSRSLKLLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_DESVM
Sequence: MPSLGQRETQVLATIIESYIASASPVGSRAVAEHSGLHLSPASMRATMSDLTDLGYLEQPHTSAGRVPTARAFRLYVDSLLRPLPLGSAERDAIADELSRQELEISGILRRAANLLSGHARQLGMVVAPSEDEARWRSIEFAPAAEGLVLAVLMLEGGLVRTRTVRVDERYGQDELVRFGNYLNEHFRGLSLSEARDRIGHELARAGSRLEEMCVRALALSRRAVEHMGDDRELIVNGTLNMLDHAEFTDVGRMRDLLAAIEERSRLLELLDRTLSERDVRITFCQDVADGAPDGLRGCSVISAAYGGDTPRGVVSVVGPLRMDYAKIVPVVQCVSRALTQLFRERFAAAPCRLP
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: SYH_SHEWM
Sequence: MAKQIQAIRGMNDILPTQSPLWQKLETVLRETVAAYGYSEIRTPIVESTDLFKRSIGEVTDIVEKEMYTFDDRNGDSLTLRPEGTASTVRAGNEHGLLYNQEQRLWYMGPMFRHERPQKGRYRQFNQFGVEVYGIGTADVDAEVLMLSARLWEKLGIKEHVTLELNTLGDPAERATYRSALIEFLEQFKEQLDEESQRRMYTNPLRVLDTKNPEVQALLVDAPELMDFLGEESRAHFSHLCELLDAVGIQYVINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVEQLGGKDTPAVGFAMGLERIVLLLETLELTSDIPSTVDVYVTAMGDTSKIEAIKIAQTLRSELPNLRVMSHCGGGNFKKQMKRADKSGAQIALVIGEDELANNQVAVKYLREKKEQELVARDGLATYIAKQI
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCM1_DANRE
Sequence: MKMSRSEHSLQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTNHDYPPGLLIAFSACTTVLVAVHLFALMVSTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAGVVLLCWVKFLPIKPKGQKNGTVSAGVAAAITSTSIMVPFGLVFIVFAVHFYRSLVSHKTDRQFQELEELEDLQNELDHREEVSTLQSPGSLYP
What is the function of this protein?
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores.
What are the official names of this protein?
Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A.
What is the protein family that this protein belongs to?
Belongs to the Orai family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SLMA_ECOSM
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKDTTARLRLIVLLLLGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYATDETLLASQILAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: YBEY_BACFN
Sequence: MAITYQTEGIKMPDIKKRETTEWIKAVAATYEKRIGEIAYIFCSDEKILEVNRQYLQHDYYTDIITFDYCEGNRLSGDLFISLETVKTNSEQFNTPYEEELHRTIIHGILHLCGINDKGPGEREIMEAAENKALAMRKQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.