PharMolix/UniProtQA huggingface dataset:
Protein: HIR2_YEAST
Sequence: MRLLKYPLDIHNEQVNALAALGPYIILAGSGGHVMAWRQQQLVDTAFDRVMIKDLKPEVSFQVDQDTTGDIFFITGDLETLYIGSEHRLWGYSGWLCRDTNNINSVEKMNSKLLFECKSPSTITDVKYDINLGILFVLLSNENKILLFRHKTFDKLSEITIDKASKPITGIIDPTGQTFTVMTSDRSILVYQINKTGTHKLINKLTQHVQMYPLHYRISMSPQADILPVINSVKGVPNNATSCTALLDRNNNYKVTKTLVTPSSNGCRVLVYSPAFYEKPNLKKGTSTRYNLIATSGSTDGTILVWNTKRMKPLFNALQVSSTAINDMSWSQDGFTLFAISNDATLYTFAFQEKDLGVALPQTEIKSLQEVNKKLPKLEEPLAEQIPKSFPENIKLEESASAAPIPNDIGRSAVGKKPTKKKTANNQTNGIKTIQSTSMEFNTPSYTVPRDLKRKPKEATPSNIAPGSKKQKKELQPIDFLDTGLLLPNTSFSRIRLATPKIRSTFKYSPINNPNLILDVKNGSGNEQRPTIVKLTSKVLDQDQVLFQDFIPKLITICTAGDTFWSFCSEDGSIYIYSDSGRKLMAPLVLGVSISFLEACGTYLLCLTSIGELYCWNIEQKKLAFPTNTIYPLLNPSLRYSDDILTRAENITLCSITKKGVPLVTLSNGDGYLFDKNMETWLLVSDGWWAYGSQYWDTTNTTGLSSSKANTDSFNGSESNINEIVSDIKNDNQSIINFLECKTNDELNRKGRIKNLQRFARTILMKEGFENMEEIVTLSHLENKILISIRLEEPEEFSKLMMVYCIRLSELGYMDRLNDVFQWLYDDLPISGTGSAFADKDFKRNLLKKILIACGDIRQVQRVTTRYAKEMNIIS
What is the function of this protein?
Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly.  The HIR complex is also required for the periodic repression of three of the four histone gene loci during the cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B.  DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex.  The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
What are the official names of this protein?
Protein HIR2, Histone transcription regulator 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat HIR1 family.
Protein: RDRP_I40A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNVTKKMVTQRTIGKRKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAMITYMTRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNDSTRKKIERIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: PHNE_MYCS2
Sequence: MTTEITRPPAPPSRPSESRKPSLPGLLHLVAIAAVLATIVSAWAIDFVPTALIDGSDNIVALLQRMIPPRLDDPARIGMLAVETLLMAVLGTTLAAIASVPLAFLAARNTTPHPAVQAVARAVITFCRAMPDLLFAVLFVRALGIGVLPGVLALALHSIGMLGKVFADAIEQTDAGPREAVRSTGVGYFRELLNAVVPQVVPSWIAMFVYRIDINLRMSVVLGFVGAGGIGFALQDALRGLIYPRALGIVCVILVIIAGMELLAIAIRRILLDPSRSNPLRDRIARFGLSGVLVGSCVAAFVLLKINPLALFTWVFPSVGIFTRMVPPNFDALGVDLFTAAAQTVAIGVVATAIGIALSIPAGILAARNVSPHPALYWPARAWILVVRAVPELILAVVFVAALGLGPIAGTCALAIGSIGFLAKLVADAVEEIDPGPMEAVRSVGGGWWKTLFAAVLPQSMPALVGSSLYLFDVNVRTSTILGIVGAGGVGYLLFESIRTLNFDVAGAIVIVIFVIVYAIERLSGWIRSRLV
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphate import.  Responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Phosphate-import permease protein PhnE.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MOAC_METAC
Sequence: MIFVEKSFTHIEADRARMVDISEKNNVLRMARAAGEIVLSAETMEKIRTGTVEKGNVFATARVAAVLAVKKTPETIPMCHQIPITGIDVDLEIGKDSVSAVVEVRTVGKTGVEMEALTGVSVALLTVWDMVKSAEKDETGNYPHTLIRNIRVLEKLKG
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Probable cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: PCMD2_PONAB
Sequence: MGGAVSAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKENAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNHGVELHSDVIEYAKQKLDFFIRTSDSFDKFDFCEPSFVTGNCLEISPDCSQYDRVYCGAGVQKEHEEYMKNLLKVGGILVMPLEEKLTKITRTGPSAWETKKILAVSFAPLIQPCHSESGKSRLVQLPPVAVRSLQDLARIAIRGTIKKIIHQETVSKNGNGLKNTPRFKRRRVRRRRMETIVFLDKEVFASRISNPSDDNSCEDLEEERREEEEKTPPETKPDPPVNFLRQKVLSLPLPDPLKYYLLYYREK
What is the function of this protein?
May act as a substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  May bind to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but probably does not display methyltransferase activity.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGTL3_HUMAN
Sequence: MTSEFFAAQLRSQISDHTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVCSPVSGILFNNEWTTSALPAFTNEFGAPPSPANFIQPGKQPLLSMCPTIMVGQDGQVRMVVGAAGGTQITTDTALAIIYNLWFGYDVKRAVEEPRLHNKLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
What are the official names of this protein?
Putative glutathione hydrolase light chain 3, Putative gamma-glutamyltransferase light chain 3.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyltransferase family.
Protein: ALDEC_NOSP7
Sequence: MQQLTDQSKELDFKSETYKDAYSRINAIVIEGEQEAHENYITLAQLLPESHDELIRLSKMESRHKKGFEACGRNLAVTPDLQFAKEFFSGLHQNFQTAAAEGKVVTCLLIQSLIIECFAIAAYNIYIPVADDFARKITEGVVKEEYSHLNFGEVWLKEHFAESKAELELANRQNLPIVWKMLNQVEGDAHTMAMEKDALVEDFMIQYGEALSNIGFSTRDIMRLSAYGLIGA
What is the function of this protein?
Catalyzes the decarbonylation of fatty aldehydes to alkanes.  Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane.  Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity.
What are the official names of this protein?
Aldehyde decarbonylase, AD, Fatty aldehyde decarbonylase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde decarbonylase family.
Protein: FLGL_SALTY
Sequence: MRISTQMMYEQNMSGITNSQAEWMKLGEQMSTGKRVTNPSDDPIAASQAVVLSQAQAQNSQYALARTFATQKVSLEESVLSQVTTAIQTAQEKIVYAGNGTLSDDDRASLATDLQGIRDQLMNLANSTDGNGRYIFAGYKTEAAPFDQATGGYHGGEKSVTQQVDSARTMVIGHTGAQIFNSITSNAVPEPDGSDSEKNLFVMLDTAIAALKTPVEGNNVEKEKAAAAIDKTNRGLKNSLNNVLTVRAELGTQLSELSTLDSLGSDRALGQKLQMSNLVDVDWNSVISSYVMQQAALQASYKTFTDMQGMSLFQLNR
What are the official names of this protein?
Flagellar hook-associated protein 3, HAP3, Hook-filament junction protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: SSB_CHLPN
Sequence: MMFGHFAGYLGADPEERMTSKGKRVITLRLGVKTRVGMKDETVWCKCNIWHNRYDKMLPYLKKGSGVIVAGDISVESYMSKDGSPQSSLVISVDSLKFSPFGRNEGSRSPSLEDNHQQVGYESVSVGFEGEALDAEAIKDKDMYAGYGQEQQYVCEDVPF
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: AMIS_PSEAE
Sequence: MLGLVLLYVGAVLFLNAVWLLGKISGREVAVINFLVGVLSACVAFYLIFSAAAGQGSLKAGALTLLFAFTYLWVAANQFLEVDGKGLGWFCLFVSLTACTVAIESFAGASGPFGLWNAVNWTVWALLWFCFFLLLGLSRSIQKPVAYLTLASAIFTAWLPGLLLLGQVLKA
What is the function of this protein?
Possible transporter that might be responsible for the adsorption of amidase substrates or release of their hydrolysis products.  AmiB and AmiS may act jointly in to a two component ABC transporter system.
What are the official names of this protein?
Putative transporter protein AmiS.
What is the protein family that this protein belongs to?
Belongs to the AmiS/UreI family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CYAY_SALCH
Sequence: MNDSEFHRLADTLWLAIEERLDSWDGDSDIDCEINGGVLTLSFENGSKIIINRQEPLHQVWLATKQGGYHFDLKDDEWVCDRSGETFWDLLEQAATQQAGEKVSFR
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: SYGB_LACAC
Sequence: MAKDYLFEIGTEEMPAHVVPRSVSQLADRTRKFLKENGLKFKDIKTFSTPRRLTILVEDLAEKQDDIDEVKKGPAKKIAQDADGNWTKAAQGFARGQGMTTDDIYFEELKGTEYAYVHVQKEGKKASDILLGMSEIIKAMTFPTKMRWDSNDFEFVRPIHWLVSLFGNEVIPVKILDITAGRKTEGHRFLGDSVVLANADDYEDALKDQYVIANAEERKDMIVNQMDELVKENHWQVKPDRDLLEEVTYLVEYPTVFAGSFDEKYLNIPDEVLITSMKDNQRYFEVYDENGKLINHFIAVRNGNKDYLDNVISGNEKVLVARLDDAQFFYDEDRKYPLSHFVDRLKDVSFHDKIGSMAEKVQRVRMIGDYLAKRWNLPENVVKDFDRASELYKFDLVTQMVGEFAELQGVMGMHYARLAGEDEEVSVAIKEHYMPATAEGPLPETTVGSLLSIADKIDTIITFFGAGMIPTSSNDPYALRRYAYGIVRILLNEKWSLPFNEVLPEIISLLNGVTPARLPKSDVDQEIADFIRDRVKQYLQKNKFKYDIIDAVLASSQQDPSQILAAANVLQLHHDDEEFKPVVESLTRIDNILKKAKFKGNVEVDESLFEDNSEKELYVGVQNLQEIESLADLYQGFVQLQPVIDQYFDVNMIMDKNEKVKNNRLAQLYAVSELADRLGNLSKLVIK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MASZ_NOCFA
Sequence: MTERIQVGGLQVAKVLHDFIENEALPGSGVDSAAFWAGAEQVITDLAPRNRALLAERDEIQGKLDAWHAEHPGANYDKAAYKSFLTEIGYLRPEPADFQITTQNVDSEIAETAGPQLVVPVMNARFAINAANARWGSLYDALYGTDAIPEDNGAEKGTGYNKVRGDKVIEWARNFLDDAVTLITGSHIGSTSYAIVDGELEVGLEDGTTIGLADASQLVGYQGDPAKPTSILLKHNGLHIDIQIDPESPIGSTDTAGIKDIVLESAVTTIMDFEDSVAAVDAEDKVLCYHNWLGLMQGTLAEEVSKGGKTFTRTMNPDRVYTALDGSELRLHGRSLLFVRNVGHLMTSDAILDAQGNEVPEGIMDGLITSLIAKHSLREDVELKNSRTGSVYIVKPKMHGPDEVAFTNELFGRIEDVLGLARNTLKVGIMDEERRTTVNLKACIEAAKERVVFINTGFLDRTGDEIHTSMEAGPMVRKADMKSQQWIASYEDWNVDTGLATGLPGKAQIGKGMWAMPDLMADMLAQKIGHPKSGANTAWVPSPTAATLHATHYHLVDVFKRQAEIAKGGRRASVDEILEIPLAANPNWSPEEIRQELDNNSQSILGYVVRWIDQGVGCSKVPDIKDVALMEDRATLRISSQLMANWLRHGIVTADEVVASLERMAPVVDRQNAGDPNYRPMAPDFDGSIAFQAAKELILEGTKQPNGYTEPILHRRRREAKALSRV
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_CLOBJ
Sequence: MSKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDPNCDALRKTIANYYNLSKEEVFIGNGSDEVLSLSFLTFFNPEETIVFSDISYSFYPVYANLYKLDYKLAKLKEDFSIDINDFKNARGGAVITNPNAPTGVYLSLDSIKQILEDNINNVVMVDEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGQKELIEGLNRIKNSFNSYTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHDTYQAEDIFIKLKDENVLVRYFNKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: NUOD_LEGPC
Sequence: MIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSIGYMDRLDYVSMMCNEHAYVMAIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYRPGGVARDLPDTMPQYKPSRWHNEREIEKKNHNRQGSLLDFLWAFTERFPRCVDEYETLLTDNRIWKQRTVDIGIVSPENALQWGFTGPMLRGSGIAWDLRKKQSYAAYDRVDFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCIEWLRKHPGPVKVDDYKVTPPRRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRGHMLADGVAILASQDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FBPAP_SULTO
Sequence: MKTTISVIKADIGSLAGHHIVHPDTMAAANKVLASAKEQGIILDYYITHVGDDLQLIMTHTRGELDTKVHETAWNAFKEAAKVAKDLGLYAAGQDLLSDSFSGNVRGLGPGVAEMEIEERASEPIAIFMADKTEPGAYNLPLYKMFADPFNTPGLVIDPTMHGGFKFEVLDVYQGEAVMLSAPQEIYDLLALIGTPARYVIRRVYRNEDNLLAAVVSIERLNLIAGKYVGKDDPVMIVRLQHGLPALGEALEAFAFPHLVPGWMRGSHYGPLMPVSQRDAKATRFDGPPRLLGLGFNVKNGRLVGPTDLFDDPAFDETRRLANIVADYMRRHGPFMPHRLEPTEMEYTTLPLILEKLKDRFKKESDVYKAKESIYAKEESQGHD
What is the function of this protein?
Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
What are the official names of this protein?
Fructose-1,6-bisphosphate aldolase/phosphatase, FBP A/P, FBP aldolase/phosphatase, Fructose-1,6-bisphosphatase, FBPase.
What is the protein family that this protein belongs to?
Belongs to the FBP aldolase/phosphatase family.
Protein: MRAZ_NEIMF
Sequence: MFGGAHELSIDSKGRLAVPAKFRDILSRLYTPAVVVTLESKHKLLMYPVAEWEKVAAQLLNLKVADNPVLRRFQNLLLHNAEILEWDSAGRVLLPAGLRKRVDFDREVVLVGRANRLELWGREQWEAEMVQALDDDPDELAFQLGQTDLQL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: LUTC_BACSU
Sequence: MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLEGYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYGLKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKDIGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADIEMDLVVGVHGPVKAAYILVSDR
What is the function of this protein?
Is essential for L-lactate degradation and allows cells to grow with lactate as the sole carbon source.  May also allow cells to utilize an alternative carbon source during biofilm formation, since it contributes to the formation of architecturally complex communities when lactate is present.
What are the official names of this protein?
Lactate utilization protein C.
What is the protein family that this protein belongs to?
Belongs to the LutC/YkgG family.
Protein: DRE2_NEUCR
Sequence: MSPITLDLTSDFNPANTTGAGSSSSQPRTLLVAPPSVASHEERISALFSTYPRDTTDLHMLDRLAAGLVTLPTSTYDLILVLTDPDGSRHAEASALLSNRAVWSLLVPALKAGGKLRSEDGTLGRDTTTPEAREAVLAGLVAGADGFTKPDYAEEEAVPLRFGLKRKTNPNPVVAPIQPVAQVVTAAPAGVGFVTLDLNDDLDLDGEDDDDDVIDEDTLLTEADLRRPIQQPPECQPKPGKKRRACKDCTCGLAERLEAEDKARRDKADQALNTLKLKSEDLLELDLTVPGKTGSCGSCALGDAFRCAGCPYLGLPPFKVGEEVSILNNVPQL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35.  Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18.  Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
What are the official names of this protein?
Fe-S cluster assembly protein dre2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: CYB_PTEHP
Sequence: MTNIRKSHPLFKIINDSLIDLPAPSSISSWWNFGSLLGIWLAIQILTGLFLAMHYTSDTTTAFQSVTHICRDVNYGWILRYLHANGASMFFICLFLHVGRGLYYGSYIYKETWNVGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFLFPFIISALVVVHLLFFHETGSNNPTGIPSDSDMIPFHPYYTIKDMLGALVMILALLMLVLFSPDLLGDPDNYIPANPLNTPSHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILALMPLLHTSKQRSMMFRPLSQCMFWLVVADFLTLTWIGGQPVEHPFIIIGQLASILYFLLILVLMPMMSIVENRLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CRTF_RHOCB
Sequence: MPKDDHTGATADRTAQPTGTGKQPLVPGQPGAAPVQPGRVNFFTRIALSQRLHEIFERLPLMNRVTRREGEALFDIVSGFVQSQVLLAIVEFRVLHILAGASWPLPQLAERTGLAEDRLAVLMQAAAALKLVKFRRGLWQLAPRGAAFITVPGLEAMVRHHPVLYRDLADPVAFLKGDIEPELAGFWPYVFGPLAQEDAGLAERYSQLMADSQRVVADDTLRLVDLRDAKRVMDVGGGTGAFLRVVAKLYPELPLTLFDLPHVLSVADRFSPKLDFAPGSFRDDPIPQGADVITLVRVLYDHPDSVVEPLLAKVHAALPPGGRLIISEAMAGGAKPDRACDVYFAFYTMAMSSGRTRSPEEIKQMLEKAGFTKVSKPRTLRPFITSVIEAERG
What is the function of this protein?
Methyltransferase that mediates the O-methylation of 1-hydroxy carotenoids.  Converts hydroxyneurosporene to methoxyneurosporene or demethylspheroidene to spheroidene.  Also able to produce spirilloxanthin.
What are the official names of this protein?
Demethylspheroidene O-methyltransferase, Hydroxyneurosporene methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: RS14_MYCVP
Sequence: MAKKSKIVQNERRREIVARHAERRAELKAIIKSPSTTPEARVAAQSELNRQPRDASPVRVRNRDSVDGRPRGHLRKFGLSRVRVRELAHQGQLPGVRKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: COF2_XENTR
Sequence: MASGVTVNDEVIKVFNEMKVRKSSTPEEIKKRKKAVLFCLSPDKKEIIVEETKQILVGDIGEAVPDPYRTFVNLLPLDDCRYGLYDATYETKESKKEDLVFIFWAPDNAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLDDIKDRCTLADKLGGNVVVSLEGVPLK
What is the function of this protein?
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner.  It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin.  It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
What are the official names of this protein?
Cofilin-2.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
What are the subcellular locations of this protein?
Nucleus matrix. Cytoplasm, cytoskeleton.
Protein: ADAB_ASPNG
Sequence: MAFRIPFAQSFWQEYLSGQEANLPRLPEVEQVTETVMRILGGNPGRMQLQGTNTYLVGTGKFRILIDTGQGEASWIEALTKQLEANGLEISHVLLTHWHGDHTGGVPDLITYNPELSSRVYKNTPDLGQQAIHDGQKFHVEGATIRAVFTPGHAFDHMCFLLEEENALFTGDNVLGHGYSVVEDLGTYMTSLTRMADLNCALGYPAHGTRIEDLPAKMKEYIQHKESRMRQVLAALERSRARMTATGGGRRAGALTFPELINSMYGGIPDEIEQALTPFLSQVLWKLAEDRKVGFEGEPSQRRWFAVGPPAATAVRL
What is the function of this protein?
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist (PubMed:21866960).  The decaketide backbone of TAN-1612 is synthesized by the non-reducing polyketide synthase adaA via condensation of one acetyl-CoA starter unit with 9 malonyl-CoA units.  The FAD-dependent monooxygenase adaC then performs hydroxylation at C2 while the polaketide chain is still attached to the NRPKS adaA (PubMed:21866960).  The alpha-hydroxylation step at C2 appears to be crucial for the following C18-C1 Claisen cyclization and release of the C9-hydroxyl version of TAN-1612 from the NRPKS adaA, two steps performed by the lactamase-like protein adaB (PubMed:21866960).  Finally, the O-methyltransferase adaD performs the C9 O-methylation to complete the biosynthesis of TAN-1612 (PubMed:21866960).
What are the official names of this protein?
Lactamase-like protein adaB, 2-acetyl-2-decarboxamidoanthrotainin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: RL1_BACVZ
Sequence: MAKKGKKYVEAAKLVDRAKAYDVAEAVALTKKTNTAKFDATVEVAFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADYVGDSDYIAKIQQGWFEFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGKVEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTMGPGVKVDASTFNVK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: KAD6_SACS2
Sequence: MIIIVTGTPGVGKTVASKKLSEALNLNYLSLSQFVIENKLYTEYDELRQSYIIDEDKVKEELEKIISTSHLVIETIYPSLVSTADLVVVLRKNPFSLYNELKGRGWADIKVAENVEAEILGVISQEAREAFKDKVCEVDTTEMSTEQILNKILNKQCDGPIEWLVDTKVQRFLEELDKIISSYENDI
What is the function of this protein?
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
What are the official names of this protein?
Putative adenylate kinase, AK, ATP-AMP transphosphorylase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK6 subfamily.
Protein: CMOA_PSEPW
Sequence: MSKQPDRLFAQPLEQVPDFVFNEDVVRVFPDMIKRSVPGYPTIVENLGVLAARFAQPNTALYDLGASLGAVTQSLRRHVRSEGCRVIAVDNSAAMVERCRQYLTAQDSMFQELLPVQVLDADILALPFEPASVVAMNFTLQFIAPEQRLALLSRIRQALLPGGALILSEKLHFADDQEQNLLNELHLDFKRANGYSELEIAQKRSAIENVMKPDTLHTHTERLRAAGFSKVVPWFQCLNFASLIALP
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.