Protein: USH2A_RAT
Sequence: MYYLALSSGFLGQAIKTSILAYLASVLLAASQGVFPRLENVGAFKKVSIVPSHATCGYPGPSTFCRSAVAAEHAQLCAERLCIQDCPYRSASPPYTALLEGLRSCIPADHGDLHPYSRSNSTSFIFGSHKNCPSLQAPRLAAEFTLAVWLKPERGSTMCVLEKTADGQIVFKVTISERETMFYYRTVNGLQPPIKVMTPGRILMKKWIHHTVQVHETEVSSFVDGLEENSTAFDTRTLRDSIMDSVPSTVLIGQSLNGSELFVGRMQDFRLYNVSLTNREILELFSGDLPHLHIQSHCRCPGSHPRVHPSVQQYCIPNGVEDTLQHRVSRLNPEAHPLSFINDDDVATSWISHVFTDITQLNQGVAISIDLENGQYQVFQITIRFSSPQPVAMRIQRKKADKSLWEDWQYFARNCSVWGMKNNGDLENPNSVNCLQFPEFIPFSHGNVTFDLLTSGQKHRPGDYDFYNSSLLQEFMTATQIRLYFRGLFYPAWHTVDSRHRYYAVDEITIIGRCQCHGHAETCDRTRRPYRCLCSPHSFTEGPQCGRCSPLYNDKPFRSGNKVHAFNCKPCQCHGHASSCHYDASMDPFPLEYNRGGGGVCDDCQHHTTGRNCESCQDYFYRPIGADPADPEVCKHCDCNRDGTRNGSLLCDLVGDQCDCKRRVSGRRCFRCHIGFYGLQALDPDCCRPCDCNPSGTVDGDITCHHNSGQCSCKANVIGLRCDRCSFGFKFLRSLNADGCEPCHCNLHGSVNQLCDPLSGQCVCKKEAKGLRCDVCRENFYGLPWSACEVCDCNRAGTQAGTVCDAETGQCVCKPSVGGRRCSECKEGYFNLRQNDSHLCLPCNCEKTGTVNGSLLCDKSTGQCPCKLGVTGLRCHQCKPHRFNLTMDNPQGCQACDCDSLGTLLGSMCDPVSGQCLCLPHRQERRCVQCQPGCYSSPSNATGCLPCLCHTVATKNCICNSVTGHCYCPDPSTTGLSWHQCQDRYFRFDPLTGRCRPCHCHVAGASNGTCDAVTGQCFCKEFVTGSKCDTCVPGASHLDVNNLLACSKTPSQQPPPRGRVQSSSAINLSWSPPDFPNAHWLTYTLFRDDSEIYTTDDQHPYYTQYFLDTSLSPHTAYSYYIETSNVHSSTRSIPVIYKTKPEGSEGHLNLTHIIPVASDSITLVWTGLSNHSGPIEKYVLSCTPVDHTEPCVSYEGPETSATIRNLVPFTQYCFSVQGCTNGSCLYSSPITVTTAQAPPQRQEPPTVWKISPTELKVEWSRPVDSNGVIIRYELYMKRWPSTEESLVFESHGWFHSHPASPSANQSENVLQDPQVSTVLSGLDPHTEYAFRVLAVNMAGSVSSAWASERTGESAPVFMAAPSVSPLSPYSLSVSWEKPAENFTRGEIIGYKISMVSERSPQRDVPVMCSKLVHFAESQDQSYIVQRLKPYRTYSFTVSLCASVGCVTSALGEGQTLAAAPAQLRSPMVTGVTSTTVHIRWLPPAEVNGPPPLYRLERRESFLPAATAARTKGTRFMGDGYCRFPRTAHPDFIGIKASFWTRVPEGLILLALHPDNQEEYFALQLKSGRPYFLYNPQGSLVEVTTADDHSQQYSDGQWHEITAIRHQSFGQITLDEQYTDSSASLNGSSVTGGYTRLFVGGLPQGHTILQKRPVRRGFVGCLKDVSILKGSSPSGTWLPLDWQSSEEQVNVHHSWEGCPTDLEEGVQFLGAGFLELRSDTFHAAKDFEISLKFQTDQLNGLLLFIHNTEGLDFLAMELKSGLLSFQLNSSRILTRVEVRLGRTHCDGKWNRVTIRREGSMVSVGVNELTKSTSRAGDQPPLLTSPVYLGGIPQELQASYRHLTLEQGFRGCVKEVAFTRGAVVNLASVSSRAVRVNQDGCLSSDSTVNCGGNDSILVYRGSRQSVYESGLQPFTEYLYRVTASHKGGSVSSDWSRGRTLGSAPHSVPTPSRAQSINGYSVEVAWNEPAMVKGVLEKYILKAYSEDSAQPHMPSASTEFNNTDIRTGILTGLHPFHSYAVTLTACSRAGCTESSRALSISTPQEAPQEVQAPVAEALPNSLSFFWSPPRQANGIITQYSLYMDGRLVYTGKGQNYTVTDLRVFTAYEITVGACTRAGCTNSSRVILHTAQLPPERVDPPVLAILDSRTVHIQWKQPRQLNGILERYILYTLNPTHNSTVWDVVYNSTENLQTHLLYHLSPGCLYLIKLGACTGGGCTTSEPSQALMDETVPEGVPAPRAHSHSPDSFNISWTEPGHPNGVITTYELYLDGTLIHNSSELSCHAYGFDPGSLHTFQVQACTAKGCALGPLVENRTLEAPPEGTVNLFVKPEGSREAAVRWDAPPHPNGRLTYSVLITGNFYADQAGDNYTLLSSTKTVHSSKGDRLWVLVDRLVPCSNYTVQVNASNSQGSVLSDRVSVEMPPGAPDGLLSPRLAAATPTSLQVVWSTPARNNAPGSPRYQLQMRPDPSTRGLLELFPIPSALLSYEVTGLQPFTVYEFRLVATNGFGSAYSDWTPLMTTEDKPGPMDAPVLNVKAGMMSVAWRKPTECNGAITHYNIYQHGRLYLTVSGGVTNCTVVHLRPHTAYQFQIEACSSKGCSMSPASETVWTLPGTPEGIPGPELLPYTPTKIIVSWQPPTHLDGLVENITIERRVKEQEEVRSLVILPRSQAVRFIDNDPALRPWTHYEYRVLGSTLNGGTNSSAWVEVTTRPSRPSGVQPPTVHVLGPDAVEVTWKAPLIRNGDIVSYEIRMPDPLIEITNVTSFVLSHLVKHLIPFTNYSVSIVACSGGHGYLGGCTESLPTFATTHPALPQELTPLSISLLGQSYVGISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNLWHNIYSGTRRFYEDKGLSRFTTYEYKLFVHNSLGFTPSQEVTVTTLAGSPERGATVTASILNHTAIDVRWKRPTFQDLQGDVEYYTLFWSSGTSVESLKIFPDVDFHVIGHLAPNVEYQVFLLVFNGVHAINSTVVRVTTWEEEPRGMRPPEVVIINSTAVRVIWTSPSNPNAVITESSVYANNELHKAGAGAPGSFTLEDLSPFTIYDIQVEVCTKDACVKSSGTQVSTAEDTPSGISIPIIRDITSRSLQIDWTAPGNPNGIILGYDVLRKTWRLCSETQKLTDKPRDELCKAVKCQYPGNVCGHTCYSPGTKVCCDGLLYDPQPGYSCCEEKYIALLPNSTGVCCGGRQREAQPDHQCCSGHYIRILPGEICCPDERHNRVSVGFGDACCGTMPYATSGSQVCCAGKLQDGYRRQCCGGEMVSQDFKCCGGGEEGMVYSSLPGMLCCGQDYVNMSDTICCSASSGDSKAHVRGSDPMPVRCCHTELIPESQQCCDGVGYNPVKYVCSDEISAGMATEETRVCATVCPATMRATAHCGQCDFNATTHICTVSRGPLNPIGKETAEGLCSTAEEIVHSGDENTRSFIDTDLEPSTVYEYRVSVWNSYGRGFSQSVRASTREDVPQGVTAPRWARTGNHEDVIFLTWKEPTQSNGPITHYILLRDGRERFQGAALSFTDTQGIQPLQEYSYQLKACTAAGCADSCKVVATATRGVLESVPPPNITAQSPETLHLSWSVPEKRNDAIKEYQLWLDGKGLIYTDTNDRRQHTVTGLQPHTNYSFTLSACTSVGCTSSEPSVGQTLQAAPQGVWVTPRHIIINSTTVELYWNPPERPNGVISQYRLRRNGSLLLVGGRDDQSFTDKNLEPNSRYIYTLEARTGGGSSLSEEYLVQMPMWTPEDVHPPCNVTVLGSDSIFVAWPAPGILLPKIPVEYSILLSGGNMMLLTFSVGLRQSAYLKNLAPFTQYEIRIQACQEGCGVSPGTHVRTLEAAPVGLMPPLLKALGSHCIEVKWTPPTRPNGIITSYVIHRRPADTEEESLLFVWSEGALEFTDDTDTLRPFTLYEYRVRAWNSKGVVDSPWSSVQTLEAPPQDLPAPWVQVTSAHSVLLNWTEPEAPNGLISQYHVIYQERPDEAAPGSSTVHAFTVKGSSRQAHLFGLEPFTTYHIGVAAVNRAGKVSSPWTLIKTLESAPSGLMNFTAEQREGGRALLLQWSEPVRTNGVIKAYNVFSDGLPEYSGLGRQFLFRRLAPFTLYILTLEACTAAGCAHSVPQTLWTEEAPPDSQMAPTIQSVEPTSVRLHWSQPANPNGKIIRYEVIRRRLQGEDWGNRTVQADENTVFTEYNTEGNGWVCTDTGLQPWGLYSYRICTWNSAGHTCSSWSVVRTSQAPPDGLSPPEVSYVSTSPLQLLISWFAPRHTNGVIQSYRLQRNGVFAAASFNSSTFSYTDGQLLPFTTYSYAVLACTGGGCCTSEPTNITTPEASPAGVSPPVLWAIGAHQINVSWSPPSVPNGKIAKYLLHCDGEEHLAGQDLSLLLSNLRPFTQYNVSLVACTKGGCTASRVASAWTMEAPPEDMDPPTLHVMGPESIEITWAPPRNPHGQIRSYELRRDGAIVYIGLETRYHDFILTPGVQYGYTVTATNSRGSVLSPLVKGQTSPSAPSGLQPPKLRAGEALELLVNWNPPVRTNGKITNYTLFIRELLEGEIRTMCINTTHSSFGTRSLAVKHLKPFHRYEVRVQACTALGCTSSEWTPTQTSEIPPLLQPAPHLEVQTAAGGFQPIVAVWWAGPLQPHGKIVRFELYRRQTASWPGTSSPLLIYNGSLSSFTDRELLPFTEYEYQVWAVNSAGKVASNWTWCRTGPAPPEGLKAPTFHTVSSTQAVVNISAPSKPNGNISLFRVFSNSSGTHVMLSEGMATQQTLHDLRPFTTYAIGVEACTCFNCCSRGPTAELRTHPAPPSGLSPPQVQTLGSRMASFQWAPPQLPNGVIHSYELQLHRACPPDSAPHCPPSPTERKYWGPGHRASLAGLQPNTAYGVQVVAHNEAGSTASGWTSFRTKKEMPQYQALFSVDSNASTVWVDWSGTFVLNGQLKEYVVTDGGRRVYSGLDTTLYIPRTVDKTFFFQVTCTTDIGSVKTPLVQYDATTGFGLVLTTPGGKKGAGTKSTEFYTDTRLPRSGTPVSIRSSQSVSVLRIPSQSQLSHAYSQGSLHRSVSQLMDSPDKKALTEDSLWETIMGHSSGLCVDEEELMNAIKGFSSVTKEHTAFTDTHL
What is the function of this protein?
Involved in hearing and vision as member of the USH2 complex.  In the inner ear, required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells.  In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.
What are the official names of this protein?
Usherin, Usher syndrome type IIa protein homolog, Usher syndrome type-2A protein homolog.
What are the subcellular locations of this protein?
[Isoform 2]: Secreted. SUBCELLULAR LOCATION: Cell projection, stereocilium membrane. Photoreceptor inner segment. Note=Component of the interstereocilia ankle links in the inner ear sensory cells. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex.