PharMolix/UniProtQA huggingface dataset:
Protein: HBB1_PANTS
Sequence: MSFLSAEEKGLVNGLWSKVNVDEVGGEALGRLLVVYPWTQRFFQSFGDLSSADAIMSNAKVKAHGKKVLNSFSDGLKNIDDLKGAFAKLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGHEFNPQVQAAFQKVVAGVASALAHRYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: FSHB_CAPHI
Sequence: MKSVQFCFLFCCWRAICCRSCELTNITITVEKEECSFCISINTTWCAGYCYTRDLVYKDPARPNIQKACTFKELVYETVKVPGCARHADSLYTYPVATECHCGKCDRDSTDCTVRGLGPSYCSFSDIRE
What is the function of this protein?
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer.  Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways.  Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
What are the official names of this protein?
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted. Note=Efficient secretion requires dimerization with CGA.
Protein: TOP6B_ARATH
Sequence: MAGDDLVETKKGSSKNSKDSNESKLKQKSPAEFFAENKNIAGFDNPGKSLYTTVRELVENALDSAESISELPEVEVTIEEIVKSKFNSMIGLIDRERVDTQLYDDYETEKARGKRLAKEARASEIQAKNLASGKKNKEPGVSKVLKARGEASYYKVTCKDNGKGMPHDDIPNMFGRVLSGTKYGLKQTRGKFGLGAKMALIWSKMSTGLPIEISSSMKSQNYVTFCRLDIDIHRNIPHIHLHEKKGNKEKWHGAEIQVVIEGNWTTYRSKILHYMRQMAVITPYAQFLFRFISETPEKNVTIKFTRRTDVMPPIPIETKHHPSSVDLLLIKRLITDTSKKTLLQFLQNEFVNINKTLAARLIGEMGPDFGPSMAVKSVTSQQMVRIHQLFRQAKFDDPSGDCLSPAGEYNLRLGIIKELHPDMVATYSGSAQVFEGHPFIVEAGVSLGGRDVKQGINIFRFANRIPLLFEQGADVVTRTALKRINWNSYKINQTQDKIGVFVSIVSTKIPFKGTGKEYIGDDISEIATAVKSAIQQCCIQLKSKIVKRLQAREQQERKRSLSRYIPDATGAVYEVLKQMTEEHKTKRKRYGEEDIVMLDKVSKQIITKETLKEKLAEHVEQVDYEMALEYATQSGVSEEPRENIYLQHLDPNKSNFIDLHSPTFVFRLML
What is the function of this protein?
Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles.  Relaxes both positive and negative superturns and exhibits a strong decatenase activity.  The B subunit binds ATP.  Involved in cell-elongation processes.
What are the official names of this protein?
DNA topoisomerase 6 subunit B, AtTOP6B, Protein BRASSINOSTEROID INSENSITIVE 3, Protein ELONGATED HYPOCOTYL 6, Protein ROOT HAIRLESS 3.
What is the protein family that this protein belongs to?
Belongs to the TOP6B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLGB_CHESB
Sequence: MSAAADAAPWRLDDPHVIGALVAGRLADPFAILGPHQTAAGLVLRVLRPEADTAEAIDPDSGSSYGKLLKRHARGFFEGLISKNTAVPRYRLRFTREGDTWDEEDAYRFPSTFGDLDLYLLGEGRHQRLYEKLGAHPMACDGVDGTRFAVWAPNASRVSVVGNFNNWDGRRHQMRLHPGIGVWEIFVPGAKPGNLYKYEIIGRNGELLPPKADPVGFRAEVPPATASVVNGLPQMEWGDGEWVEHRIGKNDRKAPISIYEVHLGSWRRHEDGRYLSYDELADRLLPYVKDLGFTHIECMPVSEHPFSGSWGYQPVGLYAPTSRFGTPEDFARFVDRCHHEGIGVIIDWVPAHFPSDAHGLARFDGTALYEHEDPRLGFHRDWNTLIYNFGRREVANFLTANALFWLDRYHVDGLRVDAVASMLYLDYSRQPGEWIPNKHGGNENLEAIAFLRETNTALFGSHPGTTSIAEESTAFPGVSRPVYAGGLGFGFKWNMGWMHDTLDYMQHEPIHRQHHHDRMTFGLIYAFSENFILPLSHDEVVHGKGSLIGRMPGDRWQKFANLRAYFTFMWTHPGKKLLFMGGEFAQEREWNHDWQLDWHHLDDPMHRGVHDLIRDLNRIYRSEPALHELDCEPEGFEWIDASDPSISTYVYMRKGTGGARPVVVACNFTPVVRENFRIGLPNAGIWREILNSDDRRYGGSDVTNGTVTATTDEPWHGRPASAILRLPPLGSVVLVGEA
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: MPTA_HALVD
Sequence: MSHQLPDVQASQPDVTVGLSQVGVTGVEKLVKIARDGKRPLVLMAEFEVFVDLPGGRKGIDMSRNMQVIDEVLEAAVSEPAYRVEDMCGDAAERLLAKHEYTTTAEVSMTAELVVREDTPASGLSTQSTAEIIASATATDEGTREEIGAEVVGMTVCPCSQGMSASRARDVLQDLAVDDDTIEEFLDKVPQPGHSQRGHATLTVETQGSPEVDLMDLIDIARDSMSARIYNLAKRPDEDHMTYHAHANAKFVEDCVRSMAELSLEALDHLGDDAVVHMKQSNDESIHQHNAHAEREVTLGQLRDELDA
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin (By similarity).  Involved in archaeosine (G(+)) and folate biosynthesis (PubMed:18931107, PubMed:19478918).
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase I, GCYH-I, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: SSRP_EHRCR
Sequence: MDIVVENRKVRFNYFIIQEFDAGIVLIGSEVKSLRQRKVSIAEAYVTERNMELWLCNLHISEYNQASTRNHNPTRPRKLLLRKKQIYKISGNIKNDGFTVVPLCLYFNDKGIAKVKVVIVKGKKLHDKRETIKTRDWNREKSRILRGGN
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: POLN_HEVHY
Sequence: MEAHQFLKAPGITTAVEQAALATANSALANAVVVRPFLSHQQIEILINLMQPRQLVFRPEVFWNQPIQRVIHNELELYCRARSGRCLEIGAHPRSINDNPNVVHRCFLRPVGRDVQRWYTAPTRGPAANCRRSALRGLPAADRTYCFDGFSGCSCPAETGIALYSLHDMSPSDVAEAMFRHGMTRLYAALHLPPEVLLPPGTYRTASYLLIHDGRRVVVTYEGDTSAGYNHDVSNLRSWIRTTKVTGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGTPSLFPTSCSTKSTFHAVPAHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGTLVANEGRNASEDALTAVITAAYLTICHQRYLRTQAISKGIRRLEREHDQKFITRLYSWLFEKSGRDYIPGRQLEFYAQCRRWLSAGFHLDPRVLVFDESAPCHCRTVIRKALSKFCCFMKWLGQECTCFLQPAEGVVGDQGHDNESYEGSDVDPAESAISDISGSYVVPGTALQPLYQALDLPDEIVARACRLTATVKVSQVDGRIDCETLLGNKTFRTSFVDGAVLETNGPERHNLSFDASQSTMAAGPFSLTYAASAAGLEVRYVGAGLDHRAIFAPGVSPRSNPGEVTAFCSALYRFNREAQRHSLTGNLWFHPEGLIGLFAPFSPGHVWESAKPFCGESTLYTRTWSEVDAVSSPTRPDLGFMSEPPIPSRAATPTLAAPLPPLAPDPSPPSSAPALDEPASAATSGVPAITHQTARHRRLLFTYPDGSKVFAGSLFESTCTWLVNASNVDHCPGGGLCHAFYQRYPASFDAACFVMRDGAAAYTLTPRPIIHRVAPDYRLEHNPKRLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDAWERNHRPGDELYLPELAARWFEANRPTRPTLTITEDAARTANLAIELDSATDVGRACAGCRVTPGVVQYQFTAGVPGSGKSRSITRADVDVVVVPTRELRNAWRRRGFAAFTPHTAARVTDGRRVVIDEAPSLPPHLLLLHMQRAATVHLLGDPNQIPAIDFEHPGLVPAIRPDLAPTSWWHVTHRCPADVCELIRGAYPMIQTTSRVLRSLFWGEPAVGQKLVFTQAAKPANPGSVTVHDSQGATYTYTTIIATADARGLIQSSRAHAIVALTRHTEKWVIIDAPGLLREVGISDAIVNNFFLAGGEIGHQRPSVIPRGNPDANVDTLAAFPPSCQISAFHQLAEELGHRPAPVAAVLPPCPELEQGLLYLPQELTTCDSVVTFELTDIVHCRMAAPSQRKAVVSTLVGRYGRRTKLYNASHSDVRDSLARFIPAIGPVQVTTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKAILALLPQGVFYGDAFDDTVFSAAVAAAKASMVFENDFSEFDSTQNNFSLGLECAIMEECGMPQGLIRLYHLIRSAWILQAPKESLLGFWKKHSGEPGTLLWNTVWNMAVITHCYDFRDLQVAAFKGDDSIVLCSEYRQSPGAAVLIAGCGLKLKVDFRPMRLYAGVVVAPGLGALPDVVRFAGRLTEKNWGPGPERADELRIAVSDFLRKLTNVAQMCVDVVSRVYGVSPGLVHNLIGMLQAVADGKAHFTESVKPVLDLTNSILCRVE
What is the function of this protein?
RNA-directed RNA polymerase: Plays an essential role in the virus replication (By similarity).  Binds to the 3'-end of the genomic RNA to initiate viral replication (PubMed:11259193).
What are the official names of this protein?
Non-structural polyprotein pORF1.
What is the protein family that this protein belongs to?
Belongs to the hepevirus non-structural polyprotein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: RS3_MYCPU
Sequence: MGQKVNPNGFRYGITKQHNAIWYAEKKDFSKFLLEDQKIHQFFEKLVRQYLIGKVEIKRDQKGRVFVGVHSAKRGAMLGQEGKNIQTLTASLQKFLRQKNKDIKIDVINIDQPELNARLLAEQIAVDLENRKPFRIAQKFAIRNSLKAGAKGIKTAVSGRLNGVDMARTEGYTEGEMKLHTLRQKVDYAQATARTTYGAIGIKVWVSLGEILDGGKQ
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: TOMT_DANRE
Sequence: MVSPAIALAFLPLLLTLIIRYRYYFVLLYRAVLTRWVRDCLSGISREERAFQYILTHATPGDSQSILDTFDTWCSKVEFISNIGPKKGKILDRLLQENCPITVLELGTHCGYSTVRMARSLPIGARIYSVEMDQRNAQVAEKIIRLAGFDDDMVELIQRPSDEVIPRLREDLGVERLDLVLMDHWKRCYLPDLHLLEDSGLIGQGSIILADNVIFPGAPNFLRYARRCGLYEVRVHRATLEYMRGIPDGMAELTYIGIK
What is the function of this protein?
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity).  Required for auditory function.  Component of the hair cell's mechanotransduction (MET) machinery.  Involved in the assembly of the asymmetric tip-link MET complex.  Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells.  The function in MET is independent of the enzymatic activity (PubMed:28534737).
What are the official names of this protein?
Transmembrane O-methyltransferase homolog, Protein mercury.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Basolateral cell membrane. Note=Enriched in an apical membrane compartment above the nucleus in the hair cells. Not detectable in the hair bundle. May be present at lower levels in the endoplasmic reticulum and the basolateral membrane.
Protein: RL1_RHOP5
Sequence: MAIGKRLKKVREGIDRTKLYPIAEAIKMVKERAVSKFDETIEIAFNLGVDPRHADQMVRGVVSLPNGTGRTLRVGVFARGAKADEARAAGADVVGAEDLVEKVQGGTIEFDRCIATPDMMPLVGRLGKVLGPRGMMPNPKIGTVTMDVAGAVAGAKGGNVEFRVEKAGIVQAGIGKASFSEEKLVENIKALTDAVSKAKPAGAKGTYIQRVAVSSTMGPGVKVEPGTILG
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: QUEA_STRGC
Sequence: MNTADFDFHLPEELIAQTPLEKRDASRLLVVDRSSGEFSDQHFDSIIDQLQPGDALVMNNTRVLPARLYGEKPGTGGHVELLLLKNTEGDQWEVLAKPAKRLKVGAQVSFGDGRLTATVVDELEHGGRIVRFDYQGIFLEVLESLGEMPLPPYIHEKLADRERYQTVYAKENGSAAAPTAGLHFTKELLAQIEAKGVKLVYLTLHVGLGTFRPVSVDNLDDHEMHSEFYTLSEEAAATLREVKANGHRVIAVGTTSIRTLETIGNKFKGDIQADSGWTNIFIKPGYQWQIVDAFSTNFHLPKSTLVMLVSAFAGRDLTLKAYEHAIAERYRFFSFGDAMFIK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity).  Seems to have a role in modulation of ADS (arginine deiminase system) gene expression, perhaps exerting a negative effect on the translation of arc regulatory proteins.
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNC_SYNPW
Sequence: MIKAIVLDIEGTTCPVTFVSQTLFPFARRQLSKTICSENRPSNVTAAIEEAIAEWKNDPESKSQALLLRASNQNQPTSEDIIHYFDHLIQNDRKSTALKELQGIIWEQGYAAGELQSPLYGDVVPALNAWTQQGITLAVYSSGSVKAQQLLYAHTTDGDITNRFSQWFDTRTGPKLNADSYRIISQSIGLKPASILFVSDHPRECDAAAEAGMETRFCLREGNPFSDGGDHQMIHNLGEIKL
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: NOT2_SCHPO
Sequence: MSLANRLSHLNITGGNDFKASIGPSVGRQNEATNPWSSTSHSLENSAATVVNELQTTKEQKTPEQSTTANPLFPGNDFSDFNNHKSKLLGVITGKSTPSSQAEKSDTTNSKTGSTEELTETPADENAKQYMLESLLPIIRMEDSEMSTLQLGCDLAALGFDLAPVEEDRLISTNLFSPWAELNTKKPVSQPMFKLPACYKNVNPPPAISKIFQFSDETLFYIFYTMPRDVMQEAAAQELTNRNWRFHKELRVWLTPVPGMKPLQRTPQFERGYYMFFDPIHWKRIKKDFLLMYAALEDRAQSAVHS
What is the function of this protein?
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.  NOT2 is required for the integrity of the complex.  The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes.  Preferentially affects TC-type TATA element-dependent transcription.  Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity).
What are the official names of this protein?
General negative regulator of transcription subunit 2.
What is the protein family that this protein belongs to?
Belongs to the CNOT2/3/5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ATP6_STRGC
Sequence: MEESVNPTIQLGPVTFNLTLLAMSLLAVLLVFAFVYWASRKMTLKPSGKQNALEYLYDFVIDFTKGNIGSKYMKNYSLFLFSLFLFLVVANNLGLMAKLQTTSGENLWTSPTANIAFDLSMSFLITLICHVEGIRRRGFKKYLKAFVTPGFMTPMNILEEFTNFASLALRIYGNIFAGEVLSGLLVTLSHQAVFYYPLAFGLNLVWTAFSVFISCVQAYVFTMLTSMYLGKKINGEE
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ADRB1_MOUSE
Sequence: MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPEPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGTTPPARLLEPWTGCNGGTTTVDSDSSLDEPGRQGFSSESKV
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  This receptor binds epinephrine and norepinephrine with approximately equal affinity.  Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity).  Involved in the regulation of sleep/wake behaviors (PubMed:31473062).
What are the official names of this protein?
Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity).
Protein: MRGX1_HUMAN
Sequence: MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASEVDEGGGQLPEEILELSGSRLEQ
What is the function of this protein?
Orphan receptor.  Probably involved in the function of nociceptive neurons.  May regulate nociceptor function and/or development, including the sensation or modulation of pain.  Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731).  BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells.  G(alpha)q proteins are involved in the calcium-signaling pathway.  Activated by the antimalarial drug, chloroquine.  May mediate chloroquine-induced itch, in a histamine-independent manner.
What are the official names of this protein?
Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 3/4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GAMT2_ARATH
Sequence: MESPSLPMTAKDWTTTSLHRVFAMQGGEDDLSYVNNSDSQALAITLSKPILISSLQSIKLFSDQTPIKITDLGCATGSNTFTTVDTVVETLQRRYTARCGGGGSPEFEAFFCDLPSNDFNMLFKLLAEKQKVDSPAKYFAGGVAGSFYDRLFPRGTIHVAVSLSALHWLSQIPEKVLEKESRTWNKGKTWIEGAKKEVVEAYAEQSDKDLDDFMSCRKEEMVKGGVLFVLMAGRPSGSSSQFGDQDTRAKHPFTTTMEQAWQDLIEEGLIDEETRDGFNIPAYMRSPEEVTAGIDRCGGFKIGKMDFLKIVEYSDEKQEEWKKDPVSYGRARTNLVQAAIRPMVDAYLGPDLSHELFKRYENRVSTNQEFLHITCFYGVVVFSAIRV
What is the function of this protein?
Methylates the carboxyl group of several gibberellins (GAs).  Substrate preference is GA4 > GA34 > GA9 > GA3 > GA1 > GA51 > GA20.  No activity with diterpenes abietic acid and ent-kaurenoic acid.
What are the official names of this protein?
Gibberellic acid methyltransferase 2, Gibberellin A(4) carboxyl methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family. SABATH subfamily.
Protein: PUR9_PROM3
Sequence: MAPIALLSVSNKHGIVSLAESLHRMHGFQLLSSGGTAKVLEDAGLPVTRVAEHTGAAEILGGRVKTLHPRVHGGILAMRGDPDHEVDLEQHQIPPIDVVVVNLYPFRETVANPQVSWETAIENIDIGGPAMVRAAAKNHAHVAVLTRPDQYDRFLVALSDGVDGQLRRELALEAFEHTAAYDVAISHWMGVRLSEQASQWLEAIPLRQRLRYGENPHQQAAWYSAPKQGWGGAIQLQGKELSTNNLLDLEAALATVREFGYGTDGAHQAVQDAAVVVKHTNPCGVAIGTGVASALSRALDADRVSAFGGIVALNGLVDATTARELTSLFLECVVAPGFEPEAREILASKANLRLLELAPGAVDAAGRDHIRTILGGVLVQDQDDQLIDPTSWTVASKRAPTAEENDDLTFAWRLVRHVRSNAIVVARAGQSLGVGAGQMNRVGSARLALEAAGDQARGAVLASDGFFPFDDTVRLAANHGIRAVIQPGGSKRDADSIAVCDEFGLAMVLTGKRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: RL24_HALOH
Sequence: MRVKKGDLVEVIAGKDRGKRGKVLRVIPREDRVIVEGINIVHRHMRPTPDMPQGGIVKNEAPIHISNVMLVCPNCDEKTRIGATYLEDGQKVRKCKKCDEVVDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RRF_BACSU
Sequence: MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEYYGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAIPALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDVQKLTDEYVSKIDSVTKDKEKEIMEV
What is the function of this protein?
Plays a role in sporulation.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor, Vegetative protein 12B, VEG12B.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_PSE14
Sequence: MSNVRSDKPFVLAGRTFESRLLVGTGKYIDMEQTRLAIEASGAEIVTVAVRRTNLGQNPGEPNLLDVLPPDRYTILPNTAGCFDATEAVRTCRLSRELLDGRNLVKLEVLADQKTLFPNVIETLKAAEILVKDGFDVMVYTSDDPIIARQLAEIGCIAIMPLAGLIGSGLGICNPYNLQIILEETKVPVLVDAGVGTASDATIAMELGCEAVLMNSAIAHAQQPVMMAEAMKHAVIAGRLAYLAGRMPRKLYASASSPLDGLIK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBH_STRP3
Sequence: MANKQDLIAKVAEATELTKKDSAAAVDAVFSTIEAFLAEGEKVQLIGFGNFEVRERAARKGRNPQTGAEIEIAASKVPAFKAGKALKDAVK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.  Seems also to act as a fortuitous virulence factor in delayed sequelae by binding to heparan sulfate-proteoglycans in the extracellular matrix of target organs and acting as a nidus for in situ immune complex formation (By similarity).
What are the official names of this protein?
DNA-binding protein HU.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: ASHWN_BOVIN
Sequence: MAGDVGGRSCTDSELLLHPELLSQEFLLLTLEQKNITVENDMRVNKDSLTDLYVQHAIPLPQRDLPKSRWGKMMEKKREQHEIKKETKRSSPADGLRKRPLIVFDGSSTSTTIKVKKTENGDNDRLRPQPQASATSNTFRKSSDSSSSVSPLVLSSNLPTNNKMEHGNNDNKQNHDLTHRKSPLGPVRSPPLSPVGATPVKLKRAAPKEEAEASINLKPPEAKRKIQHVTWP
What are the official names of this protein?
Ashwin.
What is the protein family that this protein belongs to?
Belongs to the ashwin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HRPA_BORBU
Sequence: MNDFKLPIYKYKDELIKVLKNHNVLIVESPTGSGKTTQLPRIIYEAGFAKLGKIGVTQPRRIATVSIAEYIAKHIGVNVGEEVGYKIRFEEITSPKTKIKLMTDGVLLQELKKDTLLYEYDVIIIDEAHERSLNIDFILGLIKDISRKRDDFKIIVSSATINTKIFSKYFNNAPVVSIETITYPVQIIYNPPLLNTSKGMILKIKEIVLNVIKEKKAGDILIFLSGEKEIKETIKELQELNSKKNLIIFPLYGRMPKEAQEQIFMTTPKNKRKIIVSTNIAETSITIENIKIVIDSGKVKTNKFQTKTHTYSLQEVPISKSSATQRAGRAGRLSKGTCYRLYKREDYQLREDYQKEEIYRTDLSEVVLRMADIGIRDFTHFDFISKPSTHSIQTASKILKSLDAINNKNELTEIGKYMILFPLIPAHSRALVEAMINYPQAIYQTTIGLSFLSTSGIFLLPQNEEMEARQAHLKYKNPMGDLIGFVNIFEDFKKALNKEAFTKENYLDLQGLEEIANVQMQLENIISKLNIPIIQKGVFDNEGYLKSIMRGMRDYICFKTSKKKYKTIKAQNVIIHPGSLISTDSVKYFVAGEIIETTKMYARSIGVLKKEWIDDIILNEEFKHNDISSKENQITNTGQTKIINEIKIGKKIFKAEYKNNIYVIKINLETLKEIIFKNELNNQNNEDLKKIKIQLMHKNITVFNNKKFLETIEIVKNMGKDWHCIKKYETKNVNIDEPEKMKNLLECTMQFISFPPKKNALFLSLETDYSGNFRLKPKQNFIMAIEESIESIKSLIENKEYIQKLHFIKKLINKVYKKLNYFF
What is the function of this protein?
Has RNA-stimulated ATPase activity and RNA helicase activity (PubMed:24367266).  Involved in global regulation of gene expression (PubMed:21814569).  Could be involved in RNA processing and post-transcriptional gene regulation (PubMed:24367266).  Essential for both tick transmission and mouse infection (PubMed:24367266).
What are the official names of this protein?
ATP-dependent RNA helicase HrpA.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
Protein: RNF24_MOUSE
Sequence: MSSDFPHYNFRMPNIGFQNLPLNIYIVVFGTAVFVFILSLLFCCYLIRLRHQAHKEFYAYKQVILKEKVKELNLHELCAVCLEDFKPRDELGICPCKHAFHRKCLVKWLEVRKVCPLCNMPVLQLAQLHSKQDRGPPQEPLPGAENIV
What is the function of this protein?
May play a role in TRPCs intracellular trafficking.
What are the official names of this protein?
RING finger protein 24.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass membrane protein.