PharMolix/UniProtQA huggingface dataset:
Protein: CE024_XENTR
Sequence: MMRPVSSSNVAFCTSGKSSCLNQDTMRGVDQFGLYATQQSKYSHPVTHKNISCQTQETINETHLQTSTSRDLDTKSDLKKKKNLGRSGKRGRPSGTTKSAGYRTSTGRPLGTTKAAGFKTSPGRPLGTTKAAGYKVSPGRPPGSIKALSRLANLGYPSNNAGFSYPTALSRGLHSAVETTLKHPIE
What are the official names of this protein?
UPF0461 protein C5orf24 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0461 family.
Protein: RL6_TREDE
Sequence: MSRVGKMPVAIPAGVKVNVANGIFTVEGPKGKLSQDYHTEAVDFKIEGDHVLVTRKDDELQTRAYHGLYRSLLNNMVTGVSTGFTKTLVINGVGYRAEVQGKLLVMALGYSNDFSVIIPEGIEVKVDQLKVIISGASKEAVGQFASQVRKLRGPEPYKGKGIRYEDEIIKRKVGKSGVK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: TRAC_AGRFC
Sequence: MKKPSSKIREEIARLQDQLKQAETREAERIGRIALKAGLGEIDIEESQLQAAFEEVAKRFRGGKGSATGKRQAGESRTGTEPSAALASGADEGGSGEA
What are the official names of this protein?
Conjugal transfer protein TraC.
Protein: Y4849_ARATH
Sequence: MSAPAKRSSTDTQDKDLMLAADKDMEKDTWNFKSMTDDDPMDFGFGSPAKNKKNAFKLDMGFDLDGDFGSSFKMDMPDFDFSSPAKKTTKTKETSDDKPSGNSKQKKNPFAFSYDFDALDDFDLGSSPPKKGSKTTTKSMDCEEICASSKSDKSDDLDFGLDLPITRQVPSKANTDVQAKASAEKESQNYKTTDTLVVNKSKNSNQAALESMGDFEAVESPQGSRKKASQTHTMCVQPQSVDTSPLKTSCSKVEEKNEPCPSNETIAPSPLHASEIAHIAVNRETSPDIHELCRSGTKEDCPIDPENANKKMITTMESSYEKIEQTSPSISSHLCSDKIEHQQEEMGTDTQAEIQDNTKGALYNSDAGHSLTTLSGKISPGTRTSQTAKVQDLSEKLPLDPSHSMAGLDNLRAMQNKDLGLIRSRFFKKPEKPESHVLESSPIETEIQPVIRENIGSSLNPTNDTSSHEKIIHKDHSNGKTVENVAGQMDHLKLQAKNTTREKSILQINISSKLDASSLTQKLSNHLSSGVESLQKPKLNSLGRPKLGNIMADLRAVKTQRTIGGNKDQPSSAVQPEFSSSISKERNTEAPVKKSSEIHHLAPRDKTQTLHCPSSLKRKALDEDADRSLKPQLKRLSMSPRENRNVEELTHRAVQGKFSSQESRIDTKTTKEPVKESPQTKSHYQNINMANLEIPITENADNIEKAEAYTKELENICNILKKKHEEAKELLVRAVVDNNKLLMLNHPLYEDQISFL
What are the official names of this protein?
Uncharacterized protein At4g18490.
Protein: GATB_STUS1
Sequence: MQWETVIGLEIHAQLSTQSKIFSGSATTFGAEPNTQASLVDLGMPGTLPVLNAEAVRMACKFGLAIDAEIAEKNVFARKNYFYPDLPKGYQTSQMDHPIVGKGHLDITLEDGSTRRIGITRAHLEEDAGKSLHEDFHGMSGIDLNRAGTPLLEIVSEPDIRSAKEAVAYVKAIHALVRYLGICDGNMAEGSLRCDCNVSVRPKGQAEFGTRAEIKNVNSFRFIEKAINHEVQRQIELIEDGGKVVQETRLYDPNKDETRSMRSKEEANDYRYFPCPDLLPVVIEQSFLDEVRASLPELPGQKRERFEREFGLSTYDASVLSASREMADYFEQVNATCGDAKLAANWVMGELSSLLNKEGLDIEQSPVTAEQLGGMILRIKDDTISGKIAKMVFEAMAAGEGSADEIIEKKGLKQVTDSGAIEAMLDEVLAANAEQVEQYRASDEAKRGKMFGFFVGQAMKASKGKANPGQVNQLLKKKLEG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: VE6_HPV09
Sequence: MYLTEQIMDRPKPRTVKELADTLVIPLIDLLIPCKFCNRFLSYFELLNFDHKCLQLIWTEEDLVYGLCSSCAYASAQLEFTHFFQFAVVGKDIETVEGTAIGNICIRCRYCFKLLDLVEKLATCYKFEQFYKVRNSWKGLCRHCGSVE
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: CASK_OVIDA
Sequence: VALINNQFLPYPYYAKPVAVRSPAQTLQWQVLPNTVPAKSCQDQPTTMAHHPHPHLSFMAIPPKKDQDKTEIPAINTIASVEPTVHSTPTTEAVVNTVDNPEASSESIASAPETNAAQVTTTEV
What is the function of this protein?
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
What are the official names of this protein?
Kappa-casein.
What is the protein family that this protein belongs to?
Belongs to the kappa-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMG_METS4
Sequence: MVPSDRDRVLAEAGVSRETAAALDLYVAQLTRWQAIKNLVGPATLPDVWTRHIADSLQLLDAAPQARTWLDLGSGAGIPGLILAIAGVRNRPDLRVDLVESNARKGAFLQETARLTGAPARIHVARIERVVAGFRGVDVVCARALAPLPQLIAWTAPLLKSGTIGLFPKGREAQSELTAAREKWTFVADVIPSRTDSSAGIVRISSLSDPLP
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_MESH2
Sequence: MKILGIETSHDDASVALFSENKVEILLTISQFELHEQFGGTVPELASREHSRNLAIILEKLLGKNIDFSTIDAIAYTKNPGLIGPLKIGFLFASALSLFFNKPLIPIDHLLGHFWSAAIENDLEFPVLSLLISGGHTQLIFAENKNNLEIIGSTVDDALGEIYDKIGRSLGCGYPGGPKIDLIWQQNNVRNMELIDFSLPKVLENPLDFSFSGLKTQVINYTNNLKENYLFSQKKVVEIAVSFQKTVIKYLKRQLDLALKTKKNVKTITLVGGVAANSEIRKLIKTYENKYKVVIPKKEFCTDNGAMIAKAAQIFLKFNEEK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BACE1_MOUSE
Sequence: MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
What is the function of this protein?
Responsible for the proteolytic processing of the amyloid precursor protein (APP) (PubMed:29325091).  Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:29325091).  Cleaves CHL1 (PubMed:29325091).
What are the official names of this protein?
Beta-secretase 1, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Late endosome. Early endosome. Cell surface. Cytoplasmic vesicle membrane. Membrane raft. Lysosome. Recycling endosome. Cell projection, axon. Cell projection, dendrite. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (PubMed:25592972). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (By similarity).
Protein: EXBB_SALTI
Sequence: MGNNLMQTDLSVWGMYQHADIVVKCVMIGLILASVVTWAIFFSKSVEFFTQKRRLKREQLQLADARSLDQASDIAAGFSAKSLSAQLINEAQNELELSQGSEDNEGIKERTGFRLERRVAAVGRYMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIAQTQTTNLAVVAPGIAEALLATAIGLVAAIPAVVIYNIFARQIGSYKATLGDVAAQVLLLQSRDLDLNASASAQPVRAAQKLRVG
What is the function of this protein?
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.  Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
What are the official names of this protein?
Biopolymer transport protein ExbB.
What is the protein family that this protein belongs to?
Belongs to the ExbB/TolQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENO_BACCZ
Sequence: MSTIIDVYAREVLDSRGNPTVEVEVYTESGAFGRAIVPSGASTGEHEAVELRDGDKSRYLGKGVMNAVNNVNEAIAPEIVGFDVTDQAGIDRAMIELDGTPNKGKLGANAILGVSMAVAHAAADFVGLPLYRYLGGFNAKQLPTPMMNIINGGSHADNNVDFQEFMILPVGAPTFKESIRMGAEVFHALKAVLHDKGLNTAVGDEGGFAPNLGSNREALEVIIEAIEKAGYKAGENVFLGMDVASSEFYNKETGKYDLAGEGRTGLTSAEMVDFYEELCKDFPIISIEDGLDENDWDGHKLLTERLGDKVQLVGDDLFVTNTQKLAEGIEKGISNSILIKVNQIGTLTETFEAIEMAKRAGYTAVVSHRSGETEDATIADIAVATNAGQIKTGSMSRTDRIAKYNQLLRIEDELGEIAVYDGIKSFYNIKR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL9_CHLPD
Sequence: MKVILRKDVAALGDAGEVVAVKNGYANNYLIPQGMAIRATEGTLKALETERKQQVKKVEMLRKTARELAAKIEQMTLKVFAKAGESGKLFGTVTSGDIADALKAQGIEIDRRKITLEAPVKTLGKYEADAKVFSDVAVKISFEVEAEGSEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: POB3_YARLI
Sequence: MSTTEFDGIYLNQSKAHGRLRMVETGLGWKAVQKTSMGGSKETKKDEPFLLGKEELLAAFWSRGSRGFEMKIQTKNRGAANFDGFEQDNLEELKNVMKRNYGISVEQREHSVKGWNWGKTDFERSELVFSVANKPAFEIPYAEVANSNLVGKNEVALEFQQPADGRAGDELVEMRFYVPGVTSVEGDENPKKKQKTEKEGEEGKEGDDDADADDESEEEVQSTAQIFYDTLKEKADIGAVAGTAVVSLSEIYLVIPRGRYDIDMYANFMRLRGKTYDYMVQYKHVQRLIVLPKPDDLHNILVVQLDPPLRQGQTRYPFLVMQFLREAEIKVELNVDDAEFAEKYADKGLKQSYDESAHQVVGSIFRGLTGRKLTVPGSFKTVHGHAGVSCSLKASEGHLYPLERNFLFLSKPVFIPFAEIQDITLSRVGSSVTTSRTFDMTLKLRNAQGEYQFSNISKEEQEGLEAFIKSKGIRLKNDLAEEKALLAATLAEVDDDSDDGGEFRGSADEDDESPDEDFHAESDSEVAEEFDSNAESSSGEEDDE
What is the function of this protein?
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.  It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
What are the official names of this protein?
FACT complex subunit POB3, Facilitates chromatin transcription complex subunit POB3.
What is the protein family that this protein belongs to?
Belongs to the SSRP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MURC_METRJ
Sequence: MKLPDKLGPIHFIGIGGIGMSGIAEVMHNLGYTVQGSDASDNANVRRLAEKGMRTFVGHDAKNVEEAALVVVSTAIRRDNPELQAARERRLPVVRRAEMLAELMRFKSCVAIAGTHGKTTTTSLVATLLDAGNLDPTVINGGIINAYGTNARMGAGEWMVVEADESDGTFLKLPADVAIVTNIDPEHLDHFGSFDAIKDAFRRFIDNIPFYGFAVMCIDHPVVQDLVGHIEDRRIITYGENPQADVRLIDVDLRGGQSRFRVMIRDRRPGYRMEMEDLVLPMPGKHNALNATAALAVAHELGVKPDAIRQALAGFGGVKRRFTRTGEWNGATIFDDYGHHPVEIKAVLKAARASTEHGVIAVVQPHRYTRLQSLFDDFCTCFNDADTVIVAPVYAAGEQPIEGFDRDSLVAGLRSRGHRDARALERPEELAGIIADLAKPGDYVVCLGAGTITQWAYALPDELTARGR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYCD_RAT
Sequence: MTLLGSEHSLLIRRKFRSVLQLRLQQRRTQEQLANQGLIPPLKSPTEFHDPRKKLDSAKTEDSLRRKVRNRSDRASLVNMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPMDSSVKEAIKGTEVSLSKAADAFAFEDDSSRDGLSPDQARSEDPQGSGGSTPDIKSTEAPLAGPLDTIQDLTPGSESDKNDTASQLSNQSDSGKQVLGPLSTPIPVHTAVKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFLQLQILSQQQQQQQQQQQQQQQQQQQQRFSYPGMHQAHLKEPNEQMTRNPNSSSTPLNNTPLSPVKNSLSGQTGVSSLKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALVDRLRPFQDCAGNPVPNFGDITTVTFPVTPNTLPSYQSSPSGFYHFGSTSSSPPISPASSDLSAAGSLPDTFTDASPGFGLHASPVPACTDESLLSSLNGGSGPSEPDGLDSEKDKMLVEKQKVINQLTWKLRQEQRQVEELRMQLQKQKSGCNDQKPLPFLATTIKQEDVSSCPFAAQQASGKGQGHSSDSPPPACETAQLLPHCVESSGQTHVLSSTFLSPQCSPQHSPLGTLKSPQHISLPPSPNNHYFLASSSGAQRENHGVSSPNSSQGCAQMTGLQSSDKVGPTFSIPSPTFPKSSPTVPEITQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKIPKIPGSSCSPTTILPKSSASFEQASSGGQISFDHYATDSEEHLEVLLNSHSPIGKVSDVTLLKIGSEEPPFDGIMDGFPGKAAEDLFSAHELLPGPLSPMHTQLSPPSVDSSGLQLSFTESPWETMEWLDLTPPSSTPGFSNLTSSGPSIFNIDFLDVTDLNLNSPMDLHLQQW
What is the function of this protein?
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence.  Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes (By similarity).  Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).
What are the official names of this protein?
Myocardin.
What are the subcellular locations of this protein?
Nucleus.
Protein: HDAC4_MOUSE
Sequence: MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPTAVPMDLRLDHQFSLPLEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSASYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVATALKKRPLDVTDSACSSAPGSGPSSPNSSSGNVSTENGIAPTVPSAPAETSLAHRLVTREGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQDAERLALPALQQRILFPGTHLTPYLSTSPLERDGAAAHNPLLQHMVLLEQPPTQTPLVTGLGALPLHSQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLHLSKIISKPSEPPRQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQEPIESEEEEAEATRETEPGQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGSHRPLSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSSLTSVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAFRTVVMPIANEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRLVLALEGGHDLTAICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMDIHSKYWRCLQRLSSTVGHSLIEAQKCEKEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.  Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
What are the official names of this protein?
Histone deacetylase 4, HD4.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-245, Ser-465 and Ser-629 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation (By similarity). Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (PubMed:22318228).
Protein: C1QL2_HUMAN
Sequence: MALGLLIAVPLLLQAAPRGAAHYEMMGTCRMICDPYTAAPGGEPPGAKAQPPGPSTAALEVMQDLSANPPPPFIQGPKGDPGRPGKPGPRGPPGEPGPPGPRGPPGEKGDSGRPGLPGLQLTAGTASGVGVVGGGAGVGGDSEGEVTSALSATFSGPKIAFYVGLKSPHEGYEVLKFDDVVTNLGNHYDPTTGKFSCQVRGIYFFTYHILMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVVLHLDSGDEVYVKLDGGKAHGGNNNKYSTFSGFLLYPD
What is the function of this protein?
May regulate the number of excitatory synapses that are formed on hippocampus neurons.  Has no effect on inhibitory synapses (By similarity).
What are the official names of this protein?
Complement C1q-like protein 2, C1q and tumor necrosis factor-related protein 10, C1q/TNF-related protein 10.
What are the subcellular locations of this protein?
Secreted.
Protein: PSD2_ORYSJ
Sequence: MGHSPSRHNACGGGGGDGESPPSPLPSRFERFRRRLRLRHRDRAGRPGGDAHASESGTGRAIAVDEFAGIARIRIVKEKKVVVETNGPHIARISVFETNRFSKNTLVGYCEVDLFELLTKDLDEHSEVLSLLDPSSSATIVGSISISCYIEDPVETEQSFARRVLAIVDYNEDGELSLSEFSDLMKAFGNKLAVAKIEELFRQADKNGDGIVDMDELAALLANQQEKEPLISNCPVCGEILGKHDKINDMIHMTLCFDEGTGNQIMTGGFLTDKQASYGWMFKLSEWAHFSSYDVGLHSGSTASHILVFDRRTKRLVEEVIDGKIVLSMRALYQSKVGLTLIDTGVKDLLKNLSEKQGKKMSSPESAKDIPKFLELFKDQINLDEVKDPLESFKTFNEFFVRQLKPGARPIACYEQDTIATCAADSRLMTFSSVDESTRLWIKGRKFSIEGLLGKDVHSDALCNGSLVIFRLAPQDYHRFHVPVSGTLEKFVEIPGCLYTVNPIAVNSKYCNVFTENKRVVSIISTSEFGKVAFVAIGATMVGSIEFLKEEGDYVHKGDEFGYFAFGGSTVICVFEKDAIEFDADLLANSARSLETLVSVGMRLGVSTRNRDLQPQELEKCSLE
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).  Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme 2.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: YSL7_ORYSJ
Sequence: MEPVNDFQEGISTEHAFEAEPVPSLSETITPRSMVVSFILSVTLSIVAMKVTLSSGFIPSFSIPAGLLGFCVSRASIRILDYFAVAQLPFTRQENTIIQTCVVACTSITFTGGFGTYILAMGKKAAVGDVNAQNNVEEPSFARMITFLFLISFAGMFIIMPFRKVMIIRHRLTFPSGTATAHLINSFHTPQGVKQARKQVTLLFKSFGGTIAWSLFQWFFASGPGCGFKFFPTFGLEAYKHGFFFDFTMANVGIGMMCPYMIVFSVFIGTIISCGVIWPYIESKEGIWYPSNLGPNSLNGIRGYKVFIGLSMIMADCLFVFLCIMVRTTCAMIKRRRQAMQGGGGNAQPFQGIDIADQPVKSFDDRRRAQVFLRDEIPDSVTIGCYVLLSIISIAAIPHLYPQMRYSHVALIYLAAPVFAFCNAYGFGVTDMNLASTYCKIAMFAFGSWVGIKSGGVVAALVAGGITMSILGNAADVAQDLKTGYLTLTSPRAVFISEAIGTALGCVVNPTVFWVFYRVYKMGSGDMGDMPYAKLYRGFAMLSVGDGEQGLPRHSMLLFKVFFVLALALSVFREVASRKEWRIRRYIPSTIGMAITFFMPPRVPVGMCIGSLVAYLWEKMDAGRGRMLSPALASGLICGDGVGSILLSMLTLMGARAPICIKFLSRGDNVKLDAFLATLHDMR
What is the function of this protein?
May be involved in the transport of nicotianamine-chelated metals.
What are the official names of this protein?
Probable metal-nicotianamine transporter YSL7, Protein YELLOW STRIPE LIKE 7, OsYSL7.
What is the protein family that this protein belongs to?
Belongs to the YSL (TC 2.A.67.2) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: S26A7_MOUSE
Sequence: MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLKENLLPDTVSGIMLAVQQVAQGLSFAMLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERLVPQSSRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQLVMFVLQLGSATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAYVFENIKSVQLEALLFSLLSIIVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPNGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTICFAANVGLLFGVICTIAIVLGRFPRAKTLSITDMKEMELKVKTEMHDETSQQIKIISINNPLVFLNAKKFSADLMKIILKESDSNQPLDDVSKCEQNTLLSSLSNGNCNEEASQPCSSEKCSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLDTEKPIFFDSVPAAISIIQSNKNLSKASDHSEV
What is the function of this protein?
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport.  May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger, specifically chloride.  Plays a major role in gastric acid secretion.
What are the official names of this protein?
Anion exchange transporter, Solute carrier family 26 member 7.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Expressed on the basolateral membrane of acid-secreting gastric parietal cells, distal nephron segments and apical domains of proximal tubules and in the glomerulus. Expressed in the cytoplasm in recycling endosomes of kidney outer medullary collecting duct cells and in acid- secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion.
Protein: Y9264_DICDI
Sequence: MGISDQINSNLSSQSPFTVSTNPSDSMFLPTNRIAKTADWKEEKKYYYPKESIQSIYEGTTVRIVIDKQNGRLYGLEMVVEIGPLTANGATFTRLCRDVAHSMAYSVSIWNGNNEIHRLHMDHERIEMVLTKLKHERDMEDKMAGYYDDATRTALGATKQKLIFDLNFFHTVHTSDALYLNAWH
What are the official names of this protein?
Putative uncharacterized protein DDB_G0277465.
Protein: KTHY_ECO81
Sequence: MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVGDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQDKSIHTIDATQPLEAVMGAIRTTVTNWVKELDA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: YCP7_YEAST
Sequence: MQPHLDNNSNNDDVKLDTLGEQNVLSSAENITLPEDTFKSYMTYLLYEMAHYKPMIFSFLALSVSILIVVIFHNVKACDVVFGFSIFVTSILFLSTLIPFNVYISDEGFRIKLLLEVITHRPAVKGKEWRAITDNMNQYLLDNGLWSTRYYFYSSERCYKFFRFLVKEKPPGVNVNSSVKDATSTQIDAPANEASNEVIKCFSFSSDPIFEAYFVKAVEVEKQAQQEYWRKQYPDADIP
What are the official names of this protein?
DUP240 protein YCR007C.
What is the protein family that this protein belongs to?
Belongs to the DUP/COS family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.