PharMolix/UniProtQA huggingface dataset:
Protein: ACP_AZOVD
Sequence: MSTIEERVKKIVAEQLGVKEEEVTNSASFVEDLGADSLDTVELVMALEEEFETEIPDEQAEKITTVQEAIDYINAHAQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXS_THET8
Sequence: MAEVESFSLDHTKVKAPYVRLAGRKALAGGVVEKYDLRLAQPNREALPTGALHTLEHLLAGYLRDHLPGVIDLSPMGCRTGFYLVVEGPVGEEKVLEAFAQALKDVLAHEGEVPGASFRECGNYRDHDLPGAKAWAEKVLKAGLRVQATVPLEAR
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: RS11_PHYAS
Sequence: MARRKTTKRKVKKNVPFGIAHIHTTFNNTIVTITDANGNAITWSSAGALGFKGSRKSTPFAAQLAAEAVAKAAMEHGMAKIEVFIAGPGPGREAAVRSLQAAGLEITAIKDVTAVPHNGCRPPKSPRG
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: TPIS_SHEON
Sequence: MALRRPMVAGNWKMNGSAALAQELFKKFASKLQNDSAEVVLCPPSIYLESVRQLLEANKEALDGSLVRMGAQNLSQHDFGAYTGEVSGQMLKDCGCRYVIIGHSERRRMYGETSNIVAEKFAAAQKHGLTPILCVGESGPAREARRTFEVIAEELDIVIQKNGTMAFDNAIIAYEPLWAVGTGKSATPEQAQEVHAFIRKRLSEVSPFIGENIRILYGGSVTPSNAADLFAQPDVDGGLIGGASLNSTEFLSLCTIAMSA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_OCEIH
Sequence: MQAKAVAKSVRIAPRKVRLVVDLIRGKEVGEAIAILNHTQRGASPVVEKVLKSAIANAEHNYEMDADSLVISEAFVNEGATLKRFRPRAQGRASRINKRTSHITVVVTEKKEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CMT3_ARATH
Sequence: MAPKRKRPATKDDTTKSIPKPKKRAPKRAKTVKEEPVTVVEEGEKHVARFLDEPIPESEAKSTWPDRYKPIEVQPPKASSRKKTKDDEKVEIIRARCHYRRAIVDERQIYELNDDAYVQSGEGKDPFICKIIEMFEGANGKLYFTARWFYRPSDTVMKEFEILIKKKRVFFSEIQDTNELGLLEKKLNILMIPLNENTKETIPATENCDFFCDMNYFLPYDTFEAIQQETMMAISESSTISSDTDIREGAAAISEIGECSQETEGHKKATLLDLYSGCGAMSTGLCMGAQLSGLNLVTKWAVDMNAHACKSLQHNHPETNVRNMTAEDFLFLLKEWEKLCIHFSLRNSPNSEEYANLHGLNNVEDNEDVSEESENEDDGEVFTVDKIVGISFGVPKKLLKRGLYLKVRWLNYDDSHDTWEPIEGLSNCRGKIEEFVKLGYKSGILPLPGGVDVVCGGPPCQGISGHNRFRNLLDPLEDQKNKQLLVYMNIVEYLKPKFVLMENVVDMLKMAKGYLARFAVGRLLQMNYQVRNGMMAAGAYGLAQFRLRFFLWGALPSEIIPQFPLPTHDLVHRGNIVKEFQGNIVAYDEGHTVKLADKLLLKDVISDLPAVANSEKRDEITYDKDPTTPFQKFIRLRKDEASGSQSKSKSKKHVLYDHHPLNLNINDYERVCQVPKRKGANFRDFPGVIVGPGNVVKLEEGKERVKLESGKTLVPDYALTYVDGKSCKPFGRLWWDEIVPTVVTRAEPHNQVIIHPEQNRVLSIRENARLQGFPDDYKLFGPPKQKYIQVGNAVAVPVAKALGYALGTAFQGLAVGKDPLLTLPEGFAFMKPTLPSELA
What is the function of this protein?
Involved in the CpXpG methylation (e. g.  CHG cytosine) and in gene silencing (PubMed:26798133).  Methylates preferentially transposon-related sequences.  Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation.  Involved in RNA-directed DNA methylation.
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase CMT3, Protein CHROMOMETHYLASE 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL7_RHIWR
Sequence: MADLQKLVDDLSALTVLEAAELSKLLEEKWGVSAAAAVAVAAPAGGAGAGAPAAEVKDEFDVILTGDGGKKINVIKEVRAITGLGLTEAKTLVESAPKAVKEGVNKDEAEKLKKQLEEAGATVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RS19_BORRA
Sequence: MARSIKKGPFIEKSLYQKVLASSGKEKRVVIKTYSRASTIIPEMVSLTISVYNGKSFIPVYITEDLVGHKLGEFSPTRIFRGHAKSDKKGRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SBNA_STAA9
Sequence: MIEKSQACHDSLLDSVGQTPMVQLHQLFPKHEVFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLITENTHLIESTSGNLGIALAMIAKIKGLKLTCVVDPKISPTNLKIIKSYGANVEMVEEPDAHGGYLMTRIAKVQELLATIDDAYWINQYANELNWQSHYHGAGTEIVETIKQPIDYFVAPVSTTGSIMGMSRKIKEVHPNAQIVAVDAKGSVIFGDKPINRELPGIGASRVPEILNRSEINQVIHVDDYQSALGCRKLIDYEGIFAGGSTGSIIAAIEQLITSIEEGATIVTILPDRGDRYLDLVYSDTWLEKMKSRQGVKSE
What is the function of this protein?
Catalyzes the synthesis of N-((2S)-2-amino-2-carboxyethyl)-L-glutamate (ACEGA) from O-phospho-L-serine and L-glutamate.  Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics.
What are the official names of this protein?
N-(2-amino-2-carboxyethyl)-L-glutamate synthase, ACEGA synthase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.
Protein: GLGA1_SYNJA
Sequence: MYIVQIASECAPVIKAGGLGDVVYGLSRELEVRGHCVELVLPKYDTMRYDQIWGLHDAYRDLWVPWYGGAIHCSVYCGWVHGRLCFFIEPHSGDNFFNRGCYYGCPDDNMRFAFFSKAALEFLLKSNKRPDIIHCHDWQTGLVPVLLFEIYKYHGMENQRVCYTIHNFKHQGFGGPEILWATGLNREPYYFHYDRLRDNFNPFALNFMKGGIVFSNFVTTVSPTHALEARFGNYNYGLGHTLYLHQHKFRGVLNGIDYDIWNPEIDRFIPFHYTAQTLENKAKNKKALRDQLWLQDVDKPIVAYIGRLDEQKGVHLVHHAIYRSLFKNAQFVLLGSATEPGIGAWFAHEKRYLNDNPDVHIELGFNEELSHLIYAGADILVVPSHYEPCGLTQMIGLKYGTVPVVRGVGGLVDTVFDRDYDTRKLPEQRNGYVFYHTDRAALESALDRAIDLWYTAPDQFRQLQVQGMSYDYSWNYPGKEYLEIYEFIRHR
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase 1, Starch [bacterial glycogen] synthase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: CPSF1_DANRE
Sequence: MYAVYRQAHPPTAVEFAVYCNFISSQEKNLVVAGTSQLYVYRIIYDVESTSKSEKSSDGKSRKEKLEQVASFSLFGNVMSMASVQLVGTNRDALLLSFKDAKLSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHIPMVRVDPENRCAVMLVYGTCLVVLPFRKDTLADEQEGIVGEGQKSSFLPSYIIDVRELDEKLLNIIDMKFLHGYYEPTLLILFEPNQTWPGRVAVRQDTCSIVAISLNIMQKVHPVIWSLSNLPFDCNQVMAVPKPIGGVVVFAVNSLLYLNQSVPPFGVSLNSLTNGTTAFPLRPQEEVKITLDCSQASFITSDKMVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTCMMTMEPGYLFLGSRLGNSLLLRYTEKLQETPMEEGKENEEKEKQEEPPNKKKRVDSNWAGCPGKGNLPDELDEIEVYGSEAQSGTQLATYSFEVCDSILNIGPCASASMGEPAFLSEEFQTNPEPDLEVVVCSGYGKNGALSVLQKSIRPQVVTTFELPGCHDMWTVIYCEEKPEKPSAEGDGESPEEEKREPTIEDDKKKHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVYAGNIGDNKYIIQVSPMGIRLLEGVNQLHFIPVDLGSPIVHCSVADPYVVIMTAEGVVTMFVLKNDSYMGKSHRLALQKPQIHTQSRVITLCAYRDVSGMFTTENKVSFLAKEEIAIRTNSETETIIQDISNTVDDEEEMLYGESNPLTSPNKEESSRGSAAASSAHTGKESGSGRQEPSHWCLLVRENGVMEIYQLPDWRLVFLVKNFPVGQRVLVDSSASQSATQGELKKEEVTRQGDIPLVKEVALVSLGYNHSRPYLLAHVEQELLIYEAFPYDQQQAQSNLKVRFKKMPHNINYREKKVKVRKDKKPEGQGEDTLGVKGRVARFRYFQDISGYSGVFICGPSPHWMLVTSRGAMRLHPMTIDGAIESFSPFHNINCPKGFLYFNKQGELRISVLPTYLSYDAPWPVRKIPLRCTVHYVSYHVESKVYAVCTSVKEPCTRIPRMTGEEKEFETIERDERYIHPQQDKFSIQLISPVSWEAIPNTRVDLEEWEHVTCMKTVALKSQETVSGLKGYVALGTCLMQGEEVTCRGRILILDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCSGFLVSAIGQKIFLWSLKDNDLTGMAFIDTQLYIHQMYSIKNFILAADVMKSISLLRYQPESKTLSLVSRDAKPLEVYSIEFMVDNNQLGFLVSDRDKNLMVYMYLPEAKESFGGMRLLRRADFNVGSHVNAFWRMPCRGTLDTANKKALTWDNKHITWFATLDGGVGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPKAFRMLHCDRRTLQNAVKNILDGELLNKYLYLSTMERSELAKKIGTTPDIILDDLLEIERVTAHF
What is the function of this protein?
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition.  This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).  Plays a role in eye morphogenesis and the development of retinal ganglion cell projections to the tectum (PubMed:30689892).
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specific factor 1.
What is the protein family that this protein belongs to?
Belongs to the CPSF1 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: RUVA_ACAM1
Sequence: MIGFLQGYVVSLQQTSTHRTLLTLDVNQVGYDLYVPSRIRQHLPPDQEQMRVFTHLQVREDQMVLFGFAVVAERDLFRQLIAVSGIGPQLALALIDTLGLQDLVQAIVNSNTKMLVKTPGVGAKTAERIALELRSKLAEWRDQAGLKTLPSAGPIDSVQEDVEMTLLALGYTSQEVMRALQAVGQNTALAKNSDTEAWIREAIAWLSQ
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: T2C2_HERAU
Sequence: MSINPITRNKIKDYLNGFIDQQLAVYSQRNLREFHDVDSYLAAISSDGDLKPFHASIIPSAIMRLNRFERSLSTGLGSTFEECARVIALDHHAVAIRSYDIHTSLDQAVWASIDLLISNIDRNNQRQIPSITEMLEKLQSIALTGIAENHVVRADLYVQRHDGSELFFEIKSPKPNKGQCLEVMQRLLRIYAIKQNSTLPTHAFYAMAYNPWGANRASYTYSIVKKYTDFTNAVVIGQEFWSLIGESSTYTELLEIYREVGLSKSSEITKKLL
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GGWCC-3' and cleaves after G-1.
What are the official names of this protein?
Type II restriction enzyme HgiCII, R.HgiCII, Endonuclease HgiCII, Type-2 restriction enzyme HgiCII.
What is the protein family that this protein belongs to?
Belongs to the TdeIII type II restriction endonuclease family.
Protein: PDRP_BACCR
Sequence: MDNKIVYVVSDSVGETADLVVRAAMGQFPFAPDIRRVPYVEDTGTLKEVISIAKSNQALICFTLVKPDMRQYLVTEAAKEGVEAYDIIGPLIDQIEEITGQVPRYEPGVVRRLDEEYFKKIEAIEFAVKYDDGRDARGILKADIVLIGVSRTSKTPLSQYLAHNKRLKVANVPLVPEVDPPEELYQVAKEKCFGLKITPDKLNHIRKERLKSLGLSDGATYANINRIQEEIDHFEEVISRINCQVIDVSNKAIEETANIIVNAVQNQKMF
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: RPPH_RHOPB
Sequence: MTRYDDLPYRTCVGMMLLNAEGLVFIGRRLGGIEHVDETHVWQMPQGGVDPGEDPWTAAKRELYEETSVRSVEKLGEIADWLIYDIPRTVAGRSWKGRYRGQRQKWYAVRFTGDDSEIDVVSPGGGHKAEFISWRWEPMQNLPDLIVPFKRPVYERVVKEFAALAKDAAKVSGGG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: TRPF_LEPBJ
Sequence: MNENTFEKTKIKICGIRDLEIAKICREEGADYIGLNFVPSSPRKISLKDAQKIVEFYRDTKNSPEIVLLFYQNSPEEIRTVTSSLYHDLIQWVWDDPKLTFVDRKNFLGKRQICSYRVNSPIYNEDLKNIPSELLILDSYSKDAGGGTGETFNWNFISRIERKFLLAGGLNSSNVSNAIRTVKPYGVDVASGVESSPGIKDSQKVIQFIRNVRLGL
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RSGA_SACD2
Sequence: MAKRRLSKRQVDRIRERQSQRLDTSVAAPDGKQLGSEQAGLVIAHHGKQVQVETLDNSDDSPRRLRCHLRATLGSVVTGDRIVFQEDDSSGIIVAIQPRSSTLVRPDSYGKLKPVAANVDQLLITIACAPEPFSGLIDRYLAVAENLHIRPVLLFNKLDLLQSDEIDSAIANKVAKLRTLYTSLGYRCIDTCAKNGDGLDELRNTLQDNTSVFVGQSGVGKSSIIKKLLPDQEIAIGALSDAIDKGRHTTTHSELFHFPFGGDCIDSPGIREFGLWHLSPKEVTYGFIEIRDIAGLCKFRDCSHTHEPSCAVLNAVEDGSLHPERYENFQRIVQSLDDVNMQG
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_METST
Sequence: MSNLEQAERIKNLTKDHHNWMKNSLNLIASENITSRAVREAVASDLSHRYAEGLPGERLYEGCDYIDAIEEETIALSKKLYDAEHVNVQPTSGVVANLASFFALTKPGDLLMSINVPEGGHISHASVSAAGIRGLKISSVPMDDSIMNVDIDKTLSKIREKEPKAIVLGGSLFLFPQPVSEVADVAKEVGAKIIYDAAHVLGLIAGKRFQDPVKEGADIVTGSTHKTFPGPQGGIILCKEEIGRKVDNCVFPGVVSNHHLHHMAALGVATAEMLEFGKDYANQTISNAKALAQALYERGFNVLCEDQGFTESHQVAMDVAKLGDVSKMAKTLQYNNIILNKNLLPWDDVNDSDNPSGIRMGTQELTHRGFKEDEMDQVAEFIKQVVMDKKDVKEDVTEFMQDYTTVHYAFDEGCEGYDYIEF
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDST4_MOUSE
Sequence: MNLILKFRRSFRTLIVLLATFCLVSILISAYFLYSGYKQEMTLIETTAEAECADIKDLPYRSIELRTIKPIDTSKTDPTVLLFVESQYSQLGQDIIAILESSRFQYQMVIAPGKGDIPPLTDSGKGKYTLIIYENILKYVSMDSWNRELLEKYCIEYSVSIIGFHKANENSLPTTQLKGFPLNLFNNVALKDCSVNPQSPLLHITKGPKVEKGPLPGEDWTIFQYNHSTYQPVLLTELQSEKSLSFLSSQTLYATIIQDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNVKDVKALLETQNLLRTQVANFTFNLGFSGKFYHTGTEEEDEGDDLLLRSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKEFALEHGIPINLGYAVAPHHSGVYPVHIQLYAAWKKVWGIQVTSTEEYPHLKPARYRKGFIHNSIMVLPRQTCGLFTHTIFYKEYPGGPQELDKSIKGGELFLTILLNPISIFMTHLSNYGNDRLGLYTFVNLANFVHSWTNLKLQTLPPVQLAHKYFELFPEQKDPLWQNPCDDKRHKDIWSREKTCDHLPKFLVIGPQKTGTTALYLFLLMHPSIISNLPSPKTFEEVQFFNGNNYHKGIEWYMDFFPTPSNITSDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALRFNFYEVITTGHWAPPDLKTLQRRCLVPGWYAVHIERWLAYFSTSQLLIIDGQQLRSDPATVMDEVQKFLGVTPHYNYSEALTFDPQKGFWCQLLEGGKTKCLGKSKGRKYPPMDSESRTFLSSYYRDHNVELSKLLHRLGQPLPSWLRQELQKVR
What is the function of this protein?
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate.  Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.  Has low deacetylase activity but high sulfotransferase activity.
What are the official names of this protein?
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4, Glucosaminyl N-deacetylase/N-sulfotransferase 4, NDST-4, N-heparan sulfate sulfotransferase 4, N-HSST 4.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family. NDST subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: UTP25_YEAS7
Sequence: MSDSSVREKNDNFRGYRKRGRQELRKIKRSSARTEGGSTETLEDVAEDIDHRSDEDEVSDVDSGDDFDIEDEEGKKEKVYDALLTILKSEHPEPKRRRREADESNKAPAEVGEDEHENTEHGPVDDQLEIENGLLGNHEDDNDDDSSEDEKDIDSEDEQDPFESHFNQVPEKFVDELSNAFKTKSVKYKSVKGSLSDSESYIYAKPVVIGEEALVESPYRSSSIYSYFLKQRLKVQNGLLDKKTDPLTALQKKLVDPMFQYKDILYEYDSYEKDEDEYRDLYALHVLNHIYKTRDRILKNNQRLQDNPDTEHLDQGFTRPKVLIVVPTREVAYRVVDKIISKSGIDQVDKKGKFYDQFRDDSLPPKSKPKSFQHIFRGNTNDFFVVGLKFTRKAIKLYSNFYQSDIIVCSPLGIQMILENTDKKKRQDDFLSSIELMVIDQLHSIEYQNISHIFTIFDHLNKIPDQQHEADFSRIRMWYINEQAKLFRQTMVFTKYISPAANSLINGRCRNMAGRWKNHKIIGSENSSIGQSGLKIRQIFQRFDIIGNSIIEEPDYRFKFFTSVIIPGIVKSTGYEDGILIYIPDYTDFIRIRNYMKEKTTILFGDINEYSSQRQLNANRSLFQQGRLKVMLYTERLHHYRRYEIKGVKSVVFYKPPNNPEFYNEVVRFIGKNAFLGNTDLNISTVRCIYSKLDGLSLERIVGTKRAAVLSHAQKEIYEFK
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: KHSE_CHLPM
Sequence: MKSVRGFASATVGNVACGFDILGFAITEPGDEVILTRSERKHTGCPVTISSISGDGGKLPLDPRKNTSSFVVLKFLEHIRTHKGQDCTGHISLELKKHLPLSSGMGSSAASAAAALAAANELLGRPCTKMELVHFAIEGERVACGSAHADNAAPAILGNFVLIRSYTPLDLIVIPPPEKLFCSLVHPHTELRTSFARSVLPTDITLKDATRQWGNVGALVAGLLTSDYALVGRSLVDVVAEPKRAPLIPGFAEVKEAALNAGALGCSIAGSGPSIFAFSDSAETAHAAGEAMQKAFLASKKSLKSDMWVSPICREGARIL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_FRAAA
Sequence: MPKQKSHSGASKRFRITGSGKVVRQKANRRHLLEHKSSRRTRRLAGVEPLTKADAGRIKRLLAR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: UVRC_BORPE
Sequence: MPDDFNLKSFLADLPHLPGVYRHLDAAGEAMYVGKARDLKKRVSSYFQKNLASPRIAQMVAKVASVDVTVTRSEAEALLLENNLIKSLRPRYNILFRDDKSYPYLLITGHAWPRIAYYRGATSKRGQYFGPYPNSWAVRETIQILQKVFRLRTCEDTVFANRSRPCLLHQIGRCSAPCVGVIEAEDYAHDVQRAVRFLNGEAREVMDEIEARMLQASTELRFEEAAVLRDQMGSLSKVLHQQTMENVGGDDTDVIAVASAGGKICVNLAMVRGGRHLGDKPFFPTHAEGEQPAQVLEAFVAQHYADGAMPPVLVCSHALPDSGLVGLLAEQGGTRVARVLTRPQGVRRSWLEQAQKNAEMALARALTESGARAGRTLALAEALDLDTDEESLDALRIECFDISHTAGEATQASCVVFLHHDMQPSLYRRYNIVGITPGDDYAAMRQVLTRRFGKVTDGEAPMPGLVLIDGGKGQVEVARQVFVELGLDIQSLVGVAKGEGRKVGLETLVFADGRPPVALGKESAALMLIAQVRDEAHRFAITGMRARRAKTRNVSRLEEIEGIGARRRQRLLARFGGLSGVSSASIEDLASVEGISQELAVRIYDALHG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_HYLME
Sequence: MTPLRKTNPLMKLINHSLIDLPAPSNISMWWNFGSLLGACLILQIVTGLFLAMHYTPDASTAFSSVAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYLETWNVGIILLLATMATALMGYVLPWGQMSFWGATVITNLLSAVPYIGTDLVQWVWGGYSVDNATLTRFFTFHFILPFIITALAALHLLFLHETGSNNPLGISSQPDKIAFHPYYTVKDILGLFLLLLMLMSLVLFSPDLLGDPDNYTQANPLNTPPHIKPEWYFLFAYAILRSVPNKLGGVLALLLSILILAMIPALHTAKQQSMMFRPLSQLTYWLLVMNLLTLTWIGGQPVSYPFITIGQVASVLYFTTILVLMPAASLIENKMLKWT
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GUAA_ALKCK
Sequence: MQVTNHETIVVLDFGGQYNQLITRRIRDLGVYSELHSHKLTADELKEMNPIGIIFSGGPNSAYVEGSPKCDPAIYDLGIPILGICYGVQLMTHHFGGKVDKASHREYGKALLNVENQSPLFKGLPIEQTVWMSHGDKIVAPPEGFTVDASNPSCPVAAMSDESRNLYGVQFHPEVRHSEFGNDLLKNFAFDICGAKGDWSMENFIEEEIKKIREQVGDRHVLCALSGGVDSSVVAVLIHKAIGDQLTCMFIDHGLLRKGEAESVMETFTQGFNMNVVKIDASERFLTKLKGVTDPEQKRKIIGNEFIYVFDEESAKLKDKKMDFLAQGTLYTDIIESGTDTAQTIKSHHNVGGLPEDMAFELIEPLNALFKDEVRALGTELGIPDEIVWRQPFPGPGLGIRVLGEITDEKLKIVRESDAILREEIKKAGLDREIWQYFTALPNMRSVGVMGDTRTYDYTVGIRAVTSIDGMTSDWARIPWDVLEIISTRIVNEVEHVNRIVYDITSKPPSTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: CYGB2_ORYLA
Sequence: MLGVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYKNCEDVGVSVLIRFFVNFPSAKQYFSQFQDMQDPEEMEKSSQLRQHARRVMNAINTVVENLQDPEKVSSVLALVGKAHAVKHKVEPIYFKIXSGVMLSVLSEDFPEFFTAEVQLVWTKLMAAVYWHVTGAYTEVGWLQVSSSAV
What is the function of this protein?
May have a protective function during conditions of oxidative stress.  May be involved in intracellular oxygen storage or transfer.
What are the official names of this protein?
Cytoglobin-2.
What is the protein family that this protein belongs to?
Belongs to the globin family.
What are the subcellular locations of this protein?
Cytoplasm.