PharMolix/UniProtQA huggingface dataset:
Protein: FRAT1_HUMAN
Sequence: MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLVPGS
What is the function of this protein?
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.  May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
What are the official names of this protein?
Proto-oncogene FRAT1, Frequently rearranged in advanced T-cell lymphomas 1, FRAT-1.
What is the protein family that this protein belongs to?
Belongs to the GSK-3-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_BURPS
Sequence: MTDLTATPAPAEPAASAYDPTAKQKAQAKTARIPIKIVPIEKLKKPEWIRVKAATGSSRFNEIKTILREHNLHTVCEEASCPNIGECFGKGTATFMIMGDKCTRRCPFCDVGHGRPDPLDADEPKNLARTIAALKLKYVVITSVDRDDLRDGGAGHFVECIREVREQSPATRIEILTPDFRGRLDRALAILNAAPPDVMNHNLETVPRLYKEARPGSDYAHSLKLLKDFKALHPDVATKSGLMVGLGETTDEILQVMRDLRAHDVDMLTIGQYLQPSEHHLPVREYVHPDTFKMYEEEAYKMGFTHAAVGAMVRSSYHADLQAHGAGVV
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_MYCSK
Sequence: MADPARAKRLAKRISTIVASAIEYEIKDPRLAGVTITDSKVTNDLHDATLYYTVLGRSLDEEPDYAGAAAALEKAKGVLRTKVGAGTGVRFTPTLAFVRDTVPDTAHRMEELLARARAADEDLARVREGAKHAGDADPYRVSGVEEEAGGSGEVQAEFDAEDTGDRNRQDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2233_TOLAT
Sequence: MALDYKLLEIVACPICKGKLNYDKERSELVCRADKLAYPVEDDIPVLLENRARPLKEEELPL
What are the official names of this protein?
UPF0434 protein Tola_2233.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: PICK1_MOUSE
Sequence: MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGKSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIGPRRALYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKHVQDIVFQLQRFVSTMSKYYNDCYAVLQDADVFPIEVDLAHTTLAYGPNQGSFTDGEEEDEEEEDGAAREVSKDACGATGPTDKGGSWCDS
What is the function of this protein?
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence.  Involved in the clustering of various receptors, possibly by acting at the receptor internalization level.  Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors.  May be regulated upon PRKCA activation.  May regulate ASIC1/ASIC3 channel.  Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis.  Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD).  Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
What are the official names of this protein?
PRKCA-binding protein, Protein interacting with C kinase 1, Protein kinase C-alpha-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Membrane; Lipid-anchor. Postsynaptic density. Synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Also membrane-associated, present at excitatory synapses.
Protein: RSMJ_PSESM
Sequence: MIEQQAGSRIRVEALAIDGQEHAAQWAQRLGLPLHDADADFALQLTDDGLQLQQLGDDVPGAVRVDFVEGAVAHRRLFGGGTGQMIAKAVGIQPGIRPSVLDATAGLGKDAFVLASLGCEMSLIERQPIIAALLEDGLARGRGDRDIGPIIARMRLLTGNSIEIIRSWVEEPPQVIYLDPMFPHREKTALVKKEMRLFRPLVGDDMDAPALLAAALALATHRVVVKRPRKAPCIDGPKPGYALDGKSSRYDIYPRKALKPKAVEPAPDL
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_SALDC
Sequence: MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQTQQTTQTTTTAAGSAADQGVPASGQGKMITVKTDVLDLTINTRGGDVEQALLPAYPKELGSNEPFQLLETTPQFIYQAQSGLTGRDGPDNPANGPRPLYNVEKEAFVLADGQNELQVPMTYTDAAGNTFTKTFVFKRGDYAVNVNYSVQNTGEKPLEVSTFGQLKQSVNLPPHRDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIADNENLNVSSKGGWVAMLQQYFATAWIPRNDGTNNFYTANLGNGIVAIGYKAQPVLVQPGQTGAMTSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLMGSIELRHAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSSEKKKS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDHK_MANES
Sequence: MNSIEFPLLDRTTQISVISTTSNDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAVIDAITKLRKKISREIYEDRIRSQPGKRCFTTNHKFNIERTTHTGNYDQELLYQSPSTSKIPPETFFKYKRSVSSNELVN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: HIS2_PSECP
Sequence: MKNFETLFAELSEKAATRPEGSRTVAELDSGVHGIGKKVVEEAAEVWMAAEYESDEAAAEEISQLLYHLQVLMLAKGLTLEDVYKHL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_STAAB
Sequence: MRVRYKPWAEDYLKDHPELVDMDGQHAGKMTEWFDKTQPIHIEIGSGMGQFITTLAAQNPHINYISMEREKSIVYKVLDKVKEMGLTNLKIICNDAIELNEYFKDGEVSRIYLNFSDPWPKNRHAKRRLTYHTFLALYQQILNDEGDLHFKTDNRGLFAYSLESMSQFGMYFTKINLNLHQEDDGSNILTEYEKKFSDKGSRIYRMEAKFHSQK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RL19_HELMI
Sequence: MQDIIRQIEAEQLRKDIPDFKPGDTVKVHVKVVEGNRERIQLFEGIVIKRRGGGLSETFTVRRVSYGVAVERTFLVHSPRLDKIEVVRRGRVRRAKLYYLRDLSGKAARIRDKR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: PADI_AROEV
Sequence: MGRAYSTIAFDPAKCDGCGDCMTACAQAKTGTDDIARSRIQIYGREGAADKTFELALCRQCADPKCVTVCPAGALNKDGTSGVIGWDATKCVDCLLCTVGCAYAGIALDEATGHVAKCDTCDGNPACVPACPHGALKHITTANIYNEVGDWEDLFAPGLAGCQGCNTELLMRHTLRRVGPDTVLATPPGCVPGMGSVGFNGTTGTKVPVFHPLLTNTAAMLAGIKRQYKRVGRDVQALAIAGDGGASDVGFQSLSGRAERGEQMLFMVVDNEGYMNTGMQRSSCTPYGAWTSTTPVGETSRGKTQDAKNLPLIMVNHRCAYVATASTAYMEDLYDKLDKAIAASKNGFAYLHVYSPCTTAWRFPSNLNMEVARKAVETNFVMLWEYTPQDGLHFTKPVDDPLPVTDYLKAMGRFRHLTPEQVEHIQKKVVENQKFVERMTEHAHVG
What is the function of this protein?
Involved in the anaerobic metabolism of phenylalanine and phenylacetate.  Catalyzes the oxidative decarboxylation of phenylglyoxylate to benzoyl-CoA and CO(2).  It can also react slowly with 2-oxo-3-methylbutanoate and use different electron acceptors such as benzyl viologen, methyl viologen, FAD or FMN, but NAD seems to be the physiological electron acceptor.  Also catalyzes an isotope exchange between CO(2) and the carboxyl group which proves partial or complete reversibility of the oxidative decarboxylation reaction.
What are the official names of this protein?
NADH-dependent phenylglyoxylate dehydrogenase subunit beta, Phenylglyoxylate:NAD oxidoreductase, Phenylglyoxylate:acceptor oxidoreductase.
Protein: UCHL1_RAT
Sequence: MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
What is the function of this protein?
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (By similarity).  This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity).  Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity).  The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C12 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor.
Protein: ILVD_ANAD2
Sequence: MRSDRIKKGFERAPHRSLLRATGLNDGDFEKPFIGIANSHIDIIPGHYYLQEYGRIAKDEIRKAGGVPFEFNTIGVDDGIAMGHEGMKYSLPSRELIADSIETVMNAHQLDALVCIPNCDKIVPGMLMGALRVNVPTVFVSGGPMKAGHLHDGTPIDLNTAFEAVGKRAQGQLTDAELYEIECQACPSGGSCSGMFTANSMNVLCEAMGVALPGNGTVLALTPEREALVRRAARRAVEIAADERFKLRNIANRDAIHNAMVVDMAMGGSSNTVLHMLAISREAGAPLSLRDIEEIAGKVSHIAKIAPSLATVHMEDIHRAGGVPAVLREAARRGGIVREGALTVTGETVGERIRDARTADPELIRPLENAYSPVGGLAVLFGNLAIEGAVVKTAGIQPSMRRFTGAAICFDSQDEAIAGIMGGKVKPGHFVVIRYEGPKGGPGMQEMLSPTSLIMGMGLGESVALVTDGRFSGATRGACVGHVSPEAAEGGVIGLVQDGDRITIDVEARALTVDVSDAELARRRAGFRPKRRDPGSSWLRRYAHLVTNAANGAVLRSTDL
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PUS6_ARATH
Sequence: MASPALTGGYRNLTAPVSLLRTLASTRVTTPLFRSNKHSPRFISSPKRFTCLSLLKTDSQNQTTLSSSSNSGYHEYNRLMPCPAYNLPPRIEHMVVLEDDVLVSEFISKQLDLPPLYVADLIRFGAVHYALVCPKPPPTATPEEIILFEEVTSPSVLKKRSSIKGKTVREAQKTFRVTHTNQYAEAGTYLRVHVHPKRSPRCYEIDWKSRIVAVTDSYVILDKPAGTTVGGTTDNIEESCATFASRALDLPEPLKTTHQIDNCTEGCVVFARTKEYCSVFHTKIRNKEVKKLYRALAAAPLPIGIISHYMRPKNMAPRLVAEDSIQGWHLCQLEVLECKKIPWPDAATEKKHDIEDCGWTSKEFAYECTINLLTGKTHQIRAQLAACGAPLVGDSMYMPAAIAEMGNPDTNPYGKAKKHYTMEENQKETAVAEWIDRHGKEPRVGIGLQACQISWDDDDGEHFYEAGTPWWR
What are the official names of this protein?
RNA pseudouridine synthase 6, chloroplastic, RNA pseudouridylate synthase 6, RNA-uridine isomerase 6.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KTU_DROYA
Sequence: MSASAARSRNKQSKLRDDEQLDISKDEFNRIQEAFGREEFRKLFFDYVEEIQDPENRKIYEEEITQLEKERGVEVRFIHPKPGFVIKTALDGELKCFINIAGSEEIERPKNEVATDPSSGSRGLSWSIPMAQTSSRDDCDAKNNHCKVFDVVFHPDALHLAKRNKQFRQCLIDTALDAVEREYKVSLDRANLKFPKLDYKGIPRPTVIRKLADNPTAEEQEPHPLAHMFPTKPPAPGKPEPRVLPMKTKPTPVPEFTVPRYSIKHSHDVDLSEYTDELDAKLHVTVPRSLVVEIELPLLRSTAECQLDVTSKSVYLFSERQGAKYRLKLDLPFSVDDKAGQARFDTDMRRLSITLPVVRKSTKEEAQMHDTLRHFSREDSGVELHSNSESPVEEDPDGELSDSKADISEISSPTTATVRLANSPFLKNSVHYQLPSKFDCNVLDNVMAFVLHVPNVQPDSIEQLREQRSLHLQFATIGSGYYPTHYAFYVELPAEHEDSAIESVEAEAWDNNVVLKLCLSSQSETPASYLAGLDATELKEYPVHGQYNVKSSGKANAKENAPLDVKFVHNQEGQALKVTIRPGTKEEEEKGNQDQEPESDKQHQQQSQNKKAGKKQRKRNKKERSLSESACADMIFQEPLAKNPELQPKTMFKFPSQRKQRSYSECNDSIGGSHRGILKRFSRYGPRPSMSDSCSSIDDCSSYSCSVDASGTSLFSHSFGGIPEEDRSDAGLSESCKKTVRFNDHIMKQVFRLDSSILGQRKKNQKRRDLKLRAQQRRLSEGDSVDYEETRGSALKQQENQSRNCNKPNGGSVLHDSGLDLTGAPGAHSNHNESEAKNALMFEMDD
What is the function of this protein?
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella.  Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
What are the official names of this protein?
Protein kintoun, Dynein assembly factor 2, axonemal homolog, PP1-interacting protein 20.
What is the protein family that this protein belongs to?
Belongs to the PIH1 family. Kintoun subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_BREBN
Sequence: MSAIRPEEISSLIKERIANFKSEIEVVDVGTVIQVGDGIARVHGLEKAMQGELLEFQNGVMGMVLNLEEDNVGVVIMGPFRDIKEGDTVKRTGRVMEVPVGEALLGRVVNPLGQPIDGQGPIANNGFRPIESPAPGVMARKSVHEPLQTGIKAIDAMIPVGRGQRELIIGDRQTGKTAVALDTIINQKGKDMICIYVAIGQKQSTVANIVETLRKAGALEYTIIVSATASDPAPMLYLAPYTGVTMAEYFMYKGGHVLCVYDDLSKQAAAYREMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDLGAGSITALPFIETQAGDISAYIPTNVISITDGQIFLETDLFNAGQRPAVNTGLSVSRVGGSAQIKAMKKVAGPLKLELAQYRELAAFAQFGSDLDKATQARLTRGERLMEIMKQGQFDPMPVEKQVASIYSATRGFLDDIPVAEVRRFEKEMLSFLDSNKPQLLEHIRTTKDLPDEKEFNAAIEEFKKGFSVTR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RECA_ANAMM
Sequence: MSMSGSKKDVESEKQKALDAAISQIERAFGRGAIMKLKQHPAEKMDSVSTGSIALDAALGIGGLPKGRIVEIFGPESSGKTTLALHVIAEAQKQGGNCAFIDAEHALDTVYARKLGVNVGDLIVSQPDTGEQALHIVEYLVCSGAIDVIVVDSVAALTPRAEIEGDMGDQHMGLQARLLSHALRKLTSVVSKANCILVFINQIRIKIGVIYGNPEVTTGGSALKFYTSIRLDIRKVSAIKDKDNVIGNQTRVKVVKNKVAPPFKQAEFDIVYNEGISKLGEIVDMGVKFGFVEKSGAHYSYGAVKLGQGRENAKGYLKSNPDVANELEQKIRACLAESMHNSDLFAVDERTDVLEEEVF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICI1_CANLI
Sequence: STRKTSWPELVGVTAEEAEKIKEEMSGVEIQVVPPGSFVTADYKPQRVRLYVDESNKVTRTPGIG
What is the function of this protein?
Inhibits subtilisin-type microbial serine proteases including proteinase K, subtilisin BPN', subtilisin Carlsberg, subtilisin E, A. oryzae protease and S. griseus alkaline protease.  Weakly inhibits pronase E.  Does not inhibit trypsin or chymotrypsin.
What are the official names of this protein?
Subtilisin inhibitor CLSI-I.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.
Protein: ERYA_BRUA2
Sequence: MSAMREKGDIIIGIDAGTSVLKAVAFDFSGRQIESAAVRNTYVTGDHGAVTQSLAQTWQDCARALRDLGAKLPGLAQRTAAIAVTGQGDGTWLVGKDNRPVGDAWIWLDARAASTVTRLAAGPMNRARFEATGTGLNTCQQGAQMAHMDTIAPELLDNAEAALHCKDWLYLNLTGVRATDPSEASFTFGNFRTRQYDDVVIEALGLQKRRNLLPEIIDGSQSQHPLSAEAAAATGLLAGTPVSLGYVDMAMTALGAGVCGGTAGAGCSTIGSTGVHMRAKPVADIHLNKEGTGYVIALPIPGIVTQVQTNMGATINIDWILQVAADLMSTPEKPVSLGDLIPRLDDWFNASRPGAILYHPYISEAGERGPFVNANARAGFIGLSSRDRFPELVRSVVEGLGMATRDCYAAMGEMPAELRITGGAARSKALRGTLSAAVNAPVRVSAREEAGAAGAAMMAAVAIGAYPAMDDCIAEWVEPLLGASEAPDAARAHQYEELFVAYREARLALAPVWDKLASGK
What is the function of this protein?
Catalyzes the phosphorylation of erythritol to D-erythritol-1-phosphate.
What are the official names of this protein?
Erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: FAA26_MYCTO
Sequence: MPVTDRSVPSLLQERADQQPDSTAYTYIDYGSDPKGFADSLTWSQVYSRACIIAEELKLCGLPGDRVAVLAPQGLEYVLAFLGALQAGFIAVPLSTPQYGIHDDRVSAVLQDSKPVAILTTSSVVGDVTKYAASHDGQPAPVVVEVDLLDLDSPRQMPAFSRQHTGAAYLQYTSGSTRTPAGVIVSHTNVIANVTQSMYGYFGDPAKIPTGTVVSWLPLYHDMGLILGICAPLVARRRAMLMSPMSFLRRPARWMQLLATSGRCFSAAPNFAFELAVRRTSDQDMAGLDLRDVVGIVSGSERIHVATVRRFIERFAPYNLSPTAIRPSYGLAEATLYVAAPEAGAAPKTVRFDYEQLTAGQARPCGTDGSVGTELISYGSPDPSSVRIVNPETMVENPPGVVGEIWVHGDHVTMGYWQKPKQTAQVFDAKLVDPAPAAPEGPWLRTGDLGVISDGELFIMGRIKDLLIVDGRNHYPDDIEATIQEITGGRAAAIAVPDDITEQLVAIIEFKRRGSTAEEVMLKLRSVKREVTSAISKSHSLRVADLVLVSPGSIPITTSGKIRRSACVERYRSDGFKRLDVAV
What is the function of this protein?
Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension.  Catalyzes the adenylation of the long-chain fatty acids eicosanoate (C20) or docosanoate (C22), and potentially the very-long-chain fatty acid lignocerate (C24).  Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B).
What are the official names of this protein?
Long-chain-fatty-acid--AMP ligase FadD26, FAAL, Acyl-AMP synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: Y800_PSYA2
Sequence: MHCDIYKFLKHDDMYIYIARPDYPNDTDEIKDWLGVLPKDFRAGLGRSKFVMHLDLATTPALARVDKEEVLAKLASQGYFVQLPPQDVMRRQAELHARESQDSIYNT
What are the official names of this protein?
YcgL domain-containing protein Psyc_0800.
Protein: GPMA_STRPF
Sequence: MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIEFDLAFTSVLTRAIKTTNLALENAGQLWVPTEKSWRLNERHYGALTGKNKAEAAEQFGDEQVHIWRRSYDVLPPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAMPYWEEKIAPALLDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDEKLNIVKEYYLGGE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: RNPH_LISMF
Sequence: MRVDGRESNALRNIEVTPDYLMHPEGSVLIASGNTKVICSASVETKVPPFMRGEGRGWISAEYSMLPRATNTRNIRESSKGKVTGRTMEIQRLIGRALRAVVDLDALGERTIWLDCDVIQADGGTRTASITGAFIAMVMAIAKLDEAVPFAKFPVKDFLAATSVGVLEEGGTVLDLNYVEDSAAQVDMNIIMTGSGAFVELQGTGEEATFSETELAELIALGKKGISELIEIQKETLGDKVTARIKGE
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RNPS1_PONAB
Sequence: MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHRSRSSSNSSR
What is the function of this protein?
Part of pre- and post-splicing multiprotein mRNP complexes.  Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets.  The ASAP complex can inhibit RNA processing during in vitro splicing reactions.  The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis.  Enhances the formation of the ATP-dependent A complex of the spliceosome.  Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner.  Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.  Participates in mRNA 3'-end cleavage.  Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Also mediates increase of mRNA abundance and translational efficiency.  Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity).
What are the official names of this protein?
RNA-binding protein with serine-rich domain 1.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (By similarity).