PharMolix/UniProtQA huggingface dataset:
Protein: S35D1_HUMAN
Sequence: MAEVHRRQHARVKGEAPAKSSTLRDEEELGMASAETLTVFLKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSLCVGLGQMVATVAVLWVGKALRVVKFPDLDRNVPRKTFPLPLLYFGNQITGLFSTKKLNLPMFTVLRRFSILFTMFAEGVLLKKTFSWGIKMTVFAMIIGAFVAASSDLAFDLEGYAFILINDVLTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIAYFTGDAQKAVEFEGWADTLFLLQFTLSCVMGFILMYATVLCTQYNSALTTTIVGCIKNILITYIGMVFGGDYIFTWTNFIGLNISIAGSLVYSYITFTEEQLSKQSEANNKLDIKGKGAV
What is the function of this protein?
Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar (PubMed:16965264, PubMed:17599910, PubMed:31423530).  Transports various UDP-sugars including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides (PubMed:11322953, PubMed:16965264, PubMed:17599910, PubMed:31423530, PubMed:17952091).  May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics (PubMed:16965264, PubMed:17599910).  Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity).
What are the official names of this protein?
Nucleotide sugar transporter SLC35D1, Solute carrier family 35 member D1, UDP-galactose transporter-related protein 7, UGTrel7, UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, UDP-GlcA/UDP-GalNAc transporter.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SSP21_PHAJA
Sequence: GPPLLPPLP
What are the official names of this protein?
Skin secreted peptide P2-1, PjP2-1.
What are the subcellular locations of this protein?
Secreted.
Protein: RNY_LACDA
Sequence: MMNNTVFPLATVAVIFLISLVVGCLIGYAIRKNVWETRAENARQSVEAILAKAKAEVEVAKAEIQAQKQAAEAVKRDAETEKKAKILEAQEEIRDYRQKVEDELNRRRDEAARKENRLQQKEDTLDHRSSLLDDREKQLTQRKAQIKQQEEKVAGLLEEAHGLVEKQNDKLLEISRLDEEEAKKIVLAQVSDHLTKEKAELIRANEEEISARADRFAHQIIVDAIQSSAADTVAETTVSVVDLPNDDMKGRIIGREGRNIRSFEAMTGVDLIIDDTPNTVTLSGFDSIRREVAKRALQKLIKDGRIHPARIEEMVDKARKEVNDDIYEAGESALMELGIHRMNPELVKILGRLKYRTSYGQNVLAHSIEVGKLAGTMAAELGLDEKLAVRAGLLHDIGKAIDHDIEGSHVEIGVELTRKYHEPDLVVNAIAAHHGDVPKLSFIADLVVAADTISSARPGARSESLENYIRRLTELEDIAGSYDGVKQAYAIQAGREVRVMVEPGKISDDEITVLAHEIRDRVEKELDYPGNIKITVIREKRAVAVAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL34_TRIEI
Sequence: MTQRTLHGTCRKRRRVSGFRVRMRTRNGRAVIRARRKKGRERLAVY
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: DTD_BURCH
Sequence: MIALIQRVTRADVRVGGRTTGEIGAGLLALVCAERGDTEAAADKLLAKLLGYRVFSDAAGKMNLPVSNIDGEGRAGGLLLVSQFTLAADTNSGLRPSFTPAAPPDEGARLFDYFVAAARARHPIVETGEFGADMQVSLVNDGPVTFWLQVRP
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_WIGBR
Sequence: MLNRKNKENIISKINKITKSSLSILIVDPTGITSNQMNNLRKSSRKLNVNIKQVRNTLMRFAIVDTEFDCLEKYIKGSNLIAFSHSHPGSAARIFKNFTKENNKIKIKLAVFERKIITDSNIDYLANLPTHEESVINFINIIQEASIKKLIRILILINNNK
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: SM20_SCHMA
Sequence: MAFKIDDFTIQEDQVKIAKDVFKRFDKRGQEKISTTDLGPAFRALNLTVKPDTLKEWADQVDDDATGFIDFNGFLICYGKKLQEDQDERDLRDAFRVLDKNKRGEIDVEDLRWILKGLGDDLTEEEIDDMIRDTDTDGSGFVDFDEFYKLMTSE
What is the function of this protein?
Calcium-binding protein.
What are the official names of this protein?
20 kDa calcium-binding protein, Antigen SM20.
What are the subcellular locations of this protein?
Tegument membrane. Note=Associated with the tegumental membrane.
Protein: ILVD_BURMA
Sequence: MSYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDAAVAAVKDAGANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLTIVSSFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLVEAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHAAGGIPQVMKLLLDAGLLHGDCMTITGRTLAEELKDVPSVPRADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSALAAILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMVVGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: AXIN2_DANRE
Sequence: MNRTLTDPMVSSFREDDPRPPVPGEEGETTCHHPSKLAMMRPKDPVKTIMADLRCSTARRDEDGLGEPEGSASPDSPLARWTKSLHFLLGDQDGAQLFRAYLEREKCVDTLDFWFACNGFRQMDLKDTKTHRVAKAIYKRYIENNSIVAKQLKPATKTFIRDNIKRQQIDSAMFDQAQMEIQTAMEENAYQMFLTSDIYLEYVRTGCENPSHVNPNGLGGLKLVCGYLPTLNEEEEWSCNDFKAKALATVVGLSAKTLRSPPLRAVEALEKGYRSYRRSDPGNPNRFTSGYSFAPATSANDSEVSSDALTDDSMSMTDSSVDAIPPYKLGSKKQLQREMQRNMRMNGQVSLPPFPRTRRPPKEMTPVEPAAFAAQLIARLERLKREQETMSSLEERLQQIQEEEERDESEMSSSSASHSLPLLPPGTCEEDPQAILDEHLSRVLKTPGCQSPGLLRHSPRSRSPEQRPLPRGGLSTRSQSSSMNGYVPAKTFISRQSTKHIHHHYIHHHAGPKSKEQIEVEATQRVQCLCHGTSECCTAPYIRSRSLGRDQCASPAEVALGHSSTLSKRLCKSGEEVNMEGLENSLLQLPADSTDRSQNVWQWILESDRQTKHKPHSTQNVKKSHSLEPTRTHTWGGGGSSGHLRAHQPAHPFVQDPAMPPLPPPNTLAQLEEARRRLEEVSKPSKQRHSTSSLQRDKSHPVPVQNGSSAFPMDERKDPKKMSGCHSSLGSETVVTYFFCGEEIPYRRMMKTHSLTLGHFKEQLRKKGNYRYFFKRASDEFECGAVFEEVWDDCTVLPMYEGKILGKVDRMD
What is the function of this protein?
Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity).  Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos (PubMed:30467143).
What are the official names of this protein?
Axin-2, Axis inhibition protein 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGA_PSEPU
Sequence: MPDYVNWLRHASPYINAHRDCTFVVMLPGDGVEHPNFGNIVHDLVLLHSLGVRLVLVHGSRPQIESRLADRGLTPHYHRGMRITDAATLDCVIDAVGALRLAIEARLSMDIAASPMQGSRLRVASGNLVTARPIGVLEGVDYHHTGEVRRVDRKGISRLLDERSIVLLSPLGYSPTGEIFNLACEDVATRAAIELGADKLLLFGAEPGLLDADGRLVRELRPQQVAPHLQRLGSDYQGELLDAAAEACKGGVARSHIVSYAEDGALLTELFTRGGGGTLVSQEQFEVVREATIEDVGGLLELISPLEEQGILVRRSREVLEREIEQFSVVEREGMIIACAALYPIADSEAGELACLAVNPEYRHGGRGDELLERIESRARQMGLSTLFVLTTRTAHWFRERGFAPSGVERLPAARASLYNYQRNSKIFEKPL
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFBE_SALTI
Sequence: MKLLITGGCGFLGSNLASFALSQGIDLIVFDNLSRKGATDNLHWLSSLGNFEFVHGDIRNKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYNSNCNIIYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLDYARIFGLNTVVFRHSSMYGGRQFATYDQGWVGWFCQKAVEIKNGINKPFTISGNGKQVRDVLHAEDMISLYFTALANVSKIRGNAFNIGGTIVNSLSLLELFKLLEDYCNIDMRFTNLPVRESDQRVFVADIKKITNAIDWSPKVSAKDGVQKMYDWTSSI
What is the function of this protein?
Catalyzes the isomeration of CDP-paratose to CDP-tyvelose.
What are the official names of this protein?
CDP-paratose 2-epimerase, CDP-tyvelose 2-epimerase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: CYCP_PARPM
Sequence: ASPEAYVEYRKQALKASGDHMKALSAIVKGQLPLNAEAAKHAEAIAAIMESLPAAFPEGTAGIAKTEAKAVVWSKADEFKADAVKSADAAKALAQAATAGDTAQMGKALAALGGTCKGCHETFRE
What is the function of this protein?
Cytochrome c' is the most widely occurring bacterial c-type cytochrome.  Cytochromes c' are high-spin proteins and the heme has no sixth ligand.  Their exact function is not known.
What are the official names of this protein?
Cytochrome c'.
Protein: COAX_HYPNA
Sequence: MLLVIDVGNTNTVFALHDGEQWVNQWRSATDSTKTADDHASWLWRLADMQGVDLSRVQGCVVSSVVPHAQFNFRNLARRYLNVEPLFIGEPGLKTGMAVRVRHPEQVGADRIVSALGAHVAYPGDLIVIDSGTATTFDIVSADGAFEGGIISPGIYLSMRALHDAAAQLPRIAIQKPPQVIGKDTVSAMQSGVFIGYIELIDGLVRRIKAEWGRPMTVIATGGVASLFEGASETIDYYDQDILIRGLLEVWKRNR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_BRUA1
Sequence: MSRACELTGKSVQYGNNVSHANNRTRRRFLPNLCNVTLISETLGQSYRLRISANALRSVEHRGGLDAFLVKSDDKELSQRARLLKRQIAKKQAEAAA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: PT314_ARATH
Sequence: MADRSKGFMRAEFVTYAYILLYIALSSGQIFFNKWVLSSKEINFPYPLGLTLLHMIFSSVLCFLLTKVLKIVKVEEGMTLEIYVTSVIPIGAMFAMTLWLGNTAYLYISVAFAQMLKAIMPVAVFILGVAAGLEMMSCRMLLIMSIISFGVLVASYGELNINWIGVVYQMGGVVGEALRLIFMELLVKRKGIKLNPISLMYYVSPCSAICLFVPWIFLEKSKIDGNGPWNFHFVVLTLNSLCTFALNLSVFLVISHTSALTIRVAGVVKDWVVVLVSALLFADTKLTIINLFGYAIAIAGVAAYNNHKLKKEASKVVTTETPGDAESIPLVSQGNTNTER
What are the official names of this protein?
Probable sugar phosphate/phosphate translocator At3g14410.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. TPT (TC 2.A.7.9) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y1565_STAAW
Sequence: MTEHNHDSQLEINNEEELLTLFDEEGNEVLYRKVLEFYHPEFKKEYVILAEEGAQSDEDDMIELVPMINEPDESGDGGKLVPIETDEEWDMIEEVVNTEMEE
What are the official names of this protein?
UPF0473 protein MW1565.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: UB22A_XENLA
Sequence: MSPAGCSHVNSFKVENWKQNLRVIYQCFVWSGTPETRKRKAKSCICHMCGAHLNRLHSCLYCVFFGCFTKKHIHEHAKNKRHNLAIDLLYGGIYCFMCQDYIYDKDMEQVAKEEQRKAWKLQVFSPALVSPYQYTMTGVGEKYSTWEPTKRELELLQHNPKRRKITTNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHKCEMQSPNSCLVCEMSTLFQEFYSGHRSPHIPYRLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKGDDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPFWPLSPGSDAGVVNGESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKESRMNGQYQQPSDSLHNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLDSEGYLLFYHKQFLEYE
What is the function of this protein?
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.  Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator.  Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 22-A, Deubiquitinating enzyme 22-A, Ubiquitin thioesterase 22-A, Ubiquitin-specific-processing protease 22-A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. UBP8 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: OMPA_BUCAP
Sequence: MKKQALTIIFLLVSLVTGIQAKENDHWYLGTKMGWSDFNILEYRSKDITPFDTKIDTKNPLGAPVFGLFLGYEFNPYFSFEIENDTTGFSPHLIFQKNEQNIQINSLQLATKLSYPITDDFHIYTQLGGMMFWDNLSFKKDLQNIFTEKSRLIPNVSLGAEYIFNKKFITRLDYTWKSNIAKIMNLSMKPVLGDVALSFGWKFGKSNINEIFSSYIPQSSDKQYVALNENINFPFNSTELKPISHDKLQKLQKEIKNIKSKNIFIMLSGHADRIGNKEYNQKLSENRAYSIKNYFTSHGISQDKISIQGMGNEFSLTNQICKDVSDRPLLISCLAPDRRVEIEVLSD
What is the function of this protein?
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm.  Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
What are the official names of this protein?
Outer membrane protein A, Outer membrane porin A.
What is the protein family that this protein belongs to?
Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: MNME_ECOL6
Sequence: MSDNDTIVAQATPPGRGGVGILRISGLKAREVAETVLGKLPKPRYADYLPFKDADGSVLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTIPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNNVIADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPAEIWPEFIARLPAKLPITVVRNKADITGETLGMSEVNGHALIRLSARTGEGVDVLRNHLKQSMGFDTNMEGGFLARRRHLQALEQAAEHLQQGKAQLLGAWAGELLAEELRLAQQNLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STAT1_HUMAN
Sequence: MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
What is the function of this protein?
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:34508746, PubMed:35568036).  Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2.  The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036).  ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state.  In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788).  It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.  Becomes activated in response to KITLG/SCF and KIT signaling.  May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
What are the official names of this protein?
Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys- 525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788).
Protein: HIS2_PSESM
Sequence: MTDTLSRLAEVLESRKDAAADSSYVASLYHKGLNKILEKLGEESIETIIAAKDAAVSGDCSDVIYETADLWFHSMVMLAALGQHPQAVLDELDRRFGLSGHTEKAARTAE
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTI_ECO7I
Sequence: MAQFEWVHAAWLALAIVLEIVANVFLKFSDGFRRKIFGLLSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRKGWIGLVLLLAGMIMVKLA
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtI.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VATA_STRPG
Sequence: MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGPGEPVVTTGCPLSVELGPGLISEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAFIPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLVAIHAGDFTVTDTVYEIKQEDGSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKTVVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMPVAAREASIYTGITIAEYFRDMGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLGSRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISEPVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYQDDVGSYIDRKQQSNWSNKVTRAMAILQREASLEEIVRLVGLDSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLGAYFNEIMEGTAQVRDRIARSKFIPEENLEQIKGFTQKVTKEIHHVLAKGGI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: FGF8_HUMAN
Sequence: MGSPRSALSCLLLHLLVLCLQAQEGPGRGPALGRELASLFRAGREPQGVSQQHVREQSLVTDQLSRRLIRTYQLYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSRVRVRGAETGLYICMNKKGKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQREVHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR
What is the function of this protein?
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration.  Required for normal brain, eye, ear and limb development during embryogenesis.  Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044).  Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).
What are the official names of this protein?
Fibroblast growth factor 8, FGF-8, Androgen-induced growth factor, AIGF, Heparin-binding growth factor 8, HBGF-8.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: EFG_MYCS5
Sequence: MARDYDLKDYRNIGIMAHIDAGKTTTTERILYHTGKIHKIGETHDGVSQMDWMEQEKERGITITSAATTAYWKNKRINIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATNYKVPRIVYVNKMDKAGADFEAAVASVKSRLGGNAVAIQWPIGSESNFNGIIDLVTMTATTYNGESAEEEFPMEIPTDLLDVAKAKRQELLEAAANFDEEVMMMVLEGADVDIDTFKNTIRKATLTSEFFPVVCGTSFKNKGVKKMIDAVVDYLPSPLDIPPIKAYLNDQETDVVATDDGEFAALAFKVMTDPFVGSLTFFRVYRGVLEKGSYVYNSTKEQKERIGRILQMHANNRVEIDECRAGDIAAAVGLKFTTTGDTLVGEKSPKVVLEKMVFPEPVISQALEPESKAANEKLSLGLQKLSAEDPTFRTYTDEETGQTIISGMGELHLDIIVDRLKREFGVKVKVGAPQVSYRETITKSAEVEGKHIKQSGGKGQYGHVWLKFEPNHDQGFEFIDKIVGGKIPKEYIKPIQKGLEEKMAVGILAGYPMIDVKATLFDGSYHDVDSSELAYKIAASKALTKAKDLIGTVLLEPIMDVSVVVPSDHMGDVIGDLSRRRGLISDQEQRNDGAVIVRAKVPLSEMFGYSTELRSMTSGRGTYQMQFDHYEKCPKNISDEIIKKRNIQNKDEE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_ANAD2
Sequence: MNVYEGSLVGTGLKAALVVARFNSLVTEQLLVGAADALRRHGVADGDVDVFRCPGTFELPAVLRRVVATGRYDAVVALGAVIRGGTPHFEYVSAEVTKGVAHVAMEAGCAVTMGVLTCDSMEQALERAGVKAGNKGADAAAAAVEQANVLRAIARAPARKAE
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RL30E_PYRFU
Sequence: MDLAFELRKAMETGKVVLGSNETIRLAKTGGAKLIIVAKNAPKEIKDDIYYYAKLSDIPVYEFEGTSVELGTLLGKPFVVASLAIVDPGESKILAIAKR
What are the official names of this protein?
50S ribosomal protein L30e, Large ribosomal subunit protein eL30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
Protein: NDHI_THEVB
Sequence: MKFLNQITNYAKEAVQSAKYIGQGLSVTFDHMRRRPITVQYPYEKLIPSERFRGRIHFEFDKCIACEVCVRVCPINLPVVDWVFNKELKKKELKHYSIDFGVCIFCANCVEYCPTNCLSVTEEYELATYDRHELNYDSVAMGRIPYKVTQDPMVTPIREFAYLPAGVMSGHDLPAGAQRAGERPEAIANTAKSSEN
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, NAD(P)H dehydrogenase I subunit I, NDH-1 subunit I, NDH-I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.