PharMolix/UniProtQA huggingface dataset:
Protein: FLIE_CLOAB
Sequence: MRVDEFIPDSMKSILTKNTSNTNVINENQTSGDANGTNSVDFGNILNEKLQEVNDKQIDADNTTNAFIQGDDVDVHKVMLSTEEAKLSLELAVQMRNKLVDAYQELNRTQL
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: WFKN2_HUMAN
Sequence: MWAPRCRRFWSRWEQVAALLLLLLLLGVPPRSLALPPIRYSHAGICPNDMNPNLWVDAQSTCRRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQGSECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFTWPNTSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPEITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADFPLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDSGRALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAMLRPDSFVGASSARRVRKLREVMHKKTCDVLKEFLGLH
What is the function of this protein?
Protease-inhibitor that contains multiple distinct protease inhibitor domains.  Probably has serine protease- and metalloprotease-inhibitor activity.  Inhibits the biological activity of mature myostatin, but not activin (By similarity).
What are the official names of this protein?
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2, Growth and differentiation factor-associated serum protein 1, GASP-1, hGASP-1, WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein, WFIKKN-related protein.
What is the protein family that this protein belongs to?
Belongs to the WFIKKN family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROK_NOVAD
Sequence: MEHDAALLSSSEIDRIGRRIGRPLVLVGMMGVGKTTVGRKLASLLHVPFVDADEEIERAAHMPIPEIFATYGEPYFRDGERRVIARLMGTGRNTDRKVLSTGGGAFCDPATRALILERGIAVWLDSDVDTLVERVGRKDNRPLLKTGNPREILTRLKDEREPFYAQAPIHMTSGAQPHQVTASKILRAIDQWL
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGALA_ASPOR
Sequence: MRLITRWIPLANALASTMPVQVVASIENPSLLPTPPMGFNNWARFMCDLNETLFVETTDAMASNGLLEAGYNRINLDDCWMNYDRAENGSLEWNVTKFPRGLPWLGQYVKSKGFNFGIYEDSGNLTCGGYPGSEGYEEIDAEIFAAWGIDYLKLDGCNVYPKEGRTLQEEYKYLYGNWHEILSKMQQPLIFSESAPAYFSMTDNLTDWHTVMDWVPEYGELARHSVDILVYSGEGSAWDSIMTNYKFNTLVARYQRPGYYNDPDFLIADHPGLSLDEKRSQFALWASFSAPLIISAHIPDLSSEDLEYLTNQALIAVDQDPLAQQATLASRDGSLDVLTRNLADGSRLVTILNHGSESIETDISLDILGLSTDCTYKAQDLWGGSTQTIKDAIRIKLNTHATAVYKIDTDEKCSQVIPTGLIFNTASGKCLTGTSSSVGSESCNGSKSQIWQIDASGVIRTLSEQSKCLTADGKAISLQECSENNGQKWSYAITGNLKNADTGYCLTNGGGVSACGFETNSQVFGLPAGVHVAL
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase A, Melibiase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YO318_YEAST
Sequence: MCTPTTCLLADRDKSGEDRHAETNVLQGMDMLLELLLPVYARLNESGWLLWFVFHDVYEAVKMSTKESVHTRVINFPDILSTQQMRQGPSQIRTPLVMLLM
What are the official names of this protein?
Putative uncharacterized protein YOR318C.
Protein: LSPA_JANMA
Sequence: MASNKRYFSSSSSMLPWLGIAAVLVLLDQITKITITRLFVYGESHAVTSFFNLVLVYNKGAAFSFLASETGWQRYFFTIMGIGAAIFIIYLLKKHAGQRLFCWALALILGGAIGNVIDRVLYGHVIDFLDVHIGGWHWPAFNIADSAICIGAVLFIYDELRRVGK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GSA_PROM5
Sequence: MTDIFNITHSEEVFSSALKLMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDVDGNRYIDYIGSWGPAICGHAHPEVITALQEAIEKGTSFGAPCVQENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGSGVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLLVFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGRKEIMSMVAPSGPVYQAGTLSGNPLAMTAGIKTLELLKQEGTYEKMGLATSRLIEGIMQSAENNGIAINGGSVSAMFGFFLCEGPVRNFEEAKTNNSELFGKLHREMIKRGVYLAPSPFEAGFTSLAHSEEEIDRTIEAFDQSFSVIKN
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_SOLM1
Sequence: MRKYEALLLLSPELATDNRQEIVENLKGVLERQGTTMLSVDEWGMKDLAYPVQKKTRGHYTRFEFAAPATAIAEFERIVRITDGVMKFITVKLADKYVPEGA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: UVRB_PSECP
Sequence: MSLAQDINRVVAPFEVISEFKPAGDQPAAIADLTERINNGEKDVVLLGATGTGKSATTAWLIEQVQRPTLVMVQNKTLAAQLANEFRELLPNNAVEYFVSYYDYYQPEAYVAQTDTFIEKDSSINEEVERLRHSATNALLTRRDVVVVATVSCIYGLGTPEEYIAGMVTLRKGAEMNRDDLLRKFVSMQYARNDMDFHRGTFRVRGDTVEIIPMYEELAIRIEFFGDEIENIQTLHPLTGQIIQDEEEMYVFPASHYVAGPERMSRAIKRIEDELAERLQVLESQNKLVEAQRLRMRTTYDLEMMQQMGFCNGIENYSSHIDGRARGTAPHCLLDYFPDDFLLVIDESHVTVPQIGAMYEGDMSRKRNLVDFGFRLPSAMDNRPLKWDEFLERVGQTVYLSATPGKYELGKADGFVQQIIRPTGLIDPEVVVKPTKGQIDDLLGEIRTRTERNERVLVTTLTKRMAEDLTDYLLGHGVKVEYLHSDVDTLRRVELLRELRMGTFDVLVGINLLREGLDLPEVSLVSILDADKEGFLRSSTSLIQTIGRAARNVSGQVHMYADRITDSMAQAIDETNRRRAIQVAYNTEHGIDPQPLRKKIADITDQLAKEDADTDALLGSFDYGKGKRGITGANKPGAKKAAAQVRADGLAAAPAEDLVGMIAQLTEQMHGAAAELQFEVAARIRDEVSELKKELRQMQAAGHA
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_ALKPO
Sequence: MNDHKPPIEEFMGLSFNMSTVLMTTIACLIVFLITFIGTRRLSMNPSGLQNFLEWVVDFIRGIIKANMDWKVGGRFIVLAYALLFYVFVANMLGLPFELYNPTTHEVWWKSPTSDPVLTLTMAAFVVILTHYYGIKIQGFGKYLKGYITPVPFLLPFKIIEEFANTLTLGMRLFGNVYAKEILMILLVTAGTSGLIGMFGAFLPLIVWQAFGLFIGAIQAYIFAMLAMVYMAHKVESH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LNT_CAUVC
Sequence: MIAWTRFRERPWSGPALALIAGLAAALAHPPFGVLPGLLGYAGLLHLLDNADVQRPLRSVFWRGWLAGVGYFGLGTWWVGEAFLVDAATHGWMAPFAVTGMAAGLALFWGLAALLYRALRPASAWRVLTFAGAFAALEWMRGHVLTGFPWNLPGETWKAGSAPSQLAALVGAYGLTWITLAIAGAPAVWRQGRGGRAATGLAVASLIGLYGYGAIALSRPLSPSGPTTVRIVQADIKQDLKWDAERFAQIVQAYVSLTATPYAAKPADIVIWPEGALPAAVNDYLAPGTWVRQAIVDSLAPGQLLLIGGYRYEGAGPHPTYYNSLVALRRTETDLELVGIYDKHRLVPFGEYLPADRFLTVIGFKSLARLSDNFTTGPTPAPLRISPELLVQPLICYESLFPGLAKPDPNVRALINVSNDAWFGVTSGPPQHLNLASYRAIESAKPILRATPTGISAVVDARGRIVPGASLGLGESGVIDAQIPGMGQVTPYDNFGDVAFLALILISGVVSARVRIGKISSSIAPKRKLS
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PAG62_CAPHI
Sequence: RDSXVTIVPLRNMRDIVYVGXITIGTP
What are the official names of this protein?
Pregnancy-associated glycoprotein 62, PAG 62.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
Protein: TMM61_HUMAN
Sequence: MALPQMCDGSHLASTLRYCMTVSGTVVLVAGTLCFAWWSEGDATAQPGQLAPPTEYPVPEGPSPLLRSVSFVCCGAGGLLLLIGLLWSVKASIPGPPRWDPYHLSRDLYYLTVESSEKESCRTPKVVDIPTYEEAVSFPVAEGPPTPPAYPTEEALEPSGSRDALLSTQPAWPPPSYESISLALDAVSAETTPSATRSCSGLVQTARGGS
What are the official names of this protein?
Transmembrane protein 61.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PTSS1_RAT
Sequence: MASCVGSRTLSKDDVNYRMHFRMINEQQVEDITIDFFYRPHTITLLSFTIISLMYFAFTRDDCVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMYWLDPNLRYATREADIMEYAVNCHVITWERIVSHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGIYLFMIIWQLTELNTFFLKHIFVFQASHPLSWCRILFIGCITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYVVLWLLCVAFTTFLCLYGMVWYAEHYGHREKTYSECEDGTYSPEISWYHGKGSKGSEDSPPKHSNNNESHSSRRRNRHSKSKVTNGVGKK
What is the function of this protein?
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity).  Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
What are the official names of this protein?
Phosphatidylserine synthase 1, PSS-1, PtdSer synthase 1, Serine-exchange enzyme I.
What is the protein family that this protein belongs to?
Belongs to the phosphatidyl serine synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Protein: NEUS_RAT
Sequence: MAYLGLLSLVALQSLVTGAAFPDETIAEWSVNVYNHLRATGEDENILFSPLSIALAMGVMELGAQGSTLKEIRHSMGYESLKSGEEFSFLRDFSSMVSAEEGQYVMKIANSLFVQNGFHINEEFLQMMKMYFNAEVNHVDFSENVAVANYINKWVENYTNSLLKDLVSPGDFDAVTHLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLLKPQLIEEWANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLSKAVHKSFIEVNEEGSEAAVASGMIAISRMAVLFPQVIVDHPFLFLIKNRKTGTILFMGRVMHPETMNTSGHDFEEL
What is the function of this protein?
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin.  May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system.  May protect neurons from cell damage by tissue-type plasminogen activator.
What are the official names of this protein?
Neuroserpin, Peptidase inhibitor 12, PI-12, Serine protease inhibitor 17, Serpin I1.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon.
Protein: RL10_XANP2
Sequence: MDRAQKQELVTTLTDVFKSTSVVVVAHYSGLTVAQLSRLRRQMKASGATVKVAKNRLAKIALEGSDVAHVSSLLKGPTLIAYSSDPVAAPKVAVDFAKTNDKFVILGGAMGTTALNVDGVKALATLPSLDELRAKLVGLIQAPATKIAQVTTAPAAKLARVFGAYAKQDEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: PA2A7_DABSI
Sequence: MRTLWIVAVCLIGVEGNLFQFGEMILEKTGKEVVHSYAIYGCYCGWGGQGRAQDATDRCCFVHDCCYGTVNDCNPKTATYSYSFENGDIVCGDNDLCLRTVCECDRAAAICLGQNVNTYDKNYEYYSISHCTEESEQC
What is the function of this protein?
Monomer: snake venom phospholipase A2 (PLA2) RV-7 that has low enzymatic activity and is not toxic.  It inhibits the enzymatic activity of RV-4 in vitro but potentiates its lethal potency and neurotoxicity.  It may facilitate the specific binding of RV-4 to its presynaptic binding sites, probably by acting as a chaperone, minimizing distraction and destruction of RV-4 en route to the site of action by reducing non-specific binding to muscle and other organs.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 RV-7, svPLA2, F7, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 inhibitor, S4, Viperotoxin F, Viperotoxin non-toxic acidic component.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LEU1_BACC1
Sequence: MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIHRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYQAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPELVGESQNLFVLGKHSGRHAFTEKMKELGYEFTTEERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGTHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: KGUA_XANC5
Sequence: MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSADEFQGMIEAGDFFEYALVHGDWKGTARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFILPPSRQALDERMRKRGQDSEDVMAQRLAAAREEMLHFEEFDYVIINETFDIAVAEMCAIFTASRLRRQAQQQRHAGLIQALLE
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAPC6_MYCTO
Sequence: MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVGALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  The cognate antitoxin is VapB6 (By similarity).
What are the official names of this protein?
Ribonuclease VapC6, RNase VapC6, Toxin VapC6.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: RL17_XANOM
Sequence: MRHQKSGRKFNRTSAHREAMFRNMAASLFKHELIKTTLPKAKELRRVAEPLITIGKVDGVANRRLAFARLRDKEAVGKLFVELGPRYATRPGGYLRILKAGFRAGDNAPMAYVELVDRPVVAEEVAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: JOX2_ARATH
Sequence: MNKNKIDVKIETKKGSMDEWPEPIVRVQSLAESNLSSLPDRYIKPASLRPTTTEDAPTATNIPIIDLEGLFSEEGLSDDVIMARISEACRGWGFFQVVNHGVKPELMDAARENWREFFHMPVNAKETYSNSPRTYEGYGSRLGVEKGASLDWSDYYFLHLLPHHLKDFNKWPSFPPTIREVIDEYGEELVKLSGRIMRVLSTNLGLKEDKFQEAFGGENIGACLRVNYYPKCPRPELALGLSPHSDPGGMTILLPDDQVFGLQVRKDDTWITVKPHPHAFIVNIGDQIQILSNSTYKSVEHRVIVNSDKERVSLAFFYNPKSDIPIQPLQELVSTHNPPLYPPMTFDQYRLFIRTQGPQGKSHVESHISPR
What is the function of this protein?
2-oxoglutarate-dependent dioxygenase involved in the oxidation of jasmonate (JA), a stress-induced phytohormone synthesized in response to attack by pathogens and herbivores, which triggers the activation of defense responses via the JA-mediated signaling pathway (PubMed:28760569, PubMed:28559313).  Converts JA to 12-hydroxyjasmonate (12OH-JA), an inactive form of JA (PubMed:28760569, PubMed:28559313, PubMed:33516967).  Is specific to free JA, and cannot oxidize the bioactive form jasmonoyl-L-isoleucine (JA-Ile) or other JA-amino acid conjugates (PubMed:28760569, PubMed:33516967).  Prevents over-accumulation of JA and indirectly its bioactive form JA-Ile under stress response (PubMed:28760569, PubMed:28559313).  Acts as negative regulator of JA-mediated defense signaling, by contributing to 12OH-JA accumulation, which represses JA defense responses upon infection by the fungal pathogen Botrytis cinerea (PubMed:28760569, PubMed:28559313).  Acts as negative regulator of JA-mediated defense responses upon infestation by the herbivorous caterpillar Mamestra brassicae (PubMed:28559313).  May be involved in the catabolism of cytotoxic polycyclic aromatic hydrocarbons (PAHs) (PubMed:27637093).
What are the official names of this protein?
Jasmonate-induced oxygenase 2, 2-oxoglutarate-dependent dioxygenase JOX2, Jasmonic acid oxidase 2.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: CDR2_HUMAN
Sequence: MLAENLVEEFEMKEDEPWYDHQDLQQDLQLAAELGKTLLDRNTELEDSVQQMYTTNQEQLQEIEYLTKQVELLRQMNEQHAKVYEQLDVTARELEETNQKLVADSKASQQKILSLTETIECLQTNIDHLQSQVEELKSSGQGRRSPGKCDQEKPAPSFACLKELYDLRQHFVYDHVFAEKITSLQGQPSPDEEENEHLKKTVTMLQAQLSLERQKRVTMEEEYGLVLKENSELEQQLGATGAYRARALELEAEVAEMRQMLQSEHPFVNGVEKLVPDSLYVPFKEPSQSLLEEMFLTVPESHRKPLKRSSSETILSSLAGSDIVKGHEETCIRRAKAVKQRGISLLHEVDTQYSALKVKYEELLKKCQEEQDSLSHKAVQTSRAAAKDLTGVNAQSEPVASGWELASVNPEPVSSPTTPPEYKALFKEIFSCIKKTKQEIDEQRTKYRSLSSHS
What are the official names of this protein?
Cerebellar degeneration-related protein 2, Major Yo paraneoplastic antigen, Paraneoplastic cerebellar degeneration-associated antigen.
What is the protein family that this protein belongs to?
Belongs to the CDR2 family.
Protein: ENGB_LISMC
Sequence: MDVNNVELIISAVRPEQYPETDLPEYALAGRSNVGKSSFINTMIRRKSMARISQKPGKTQTLNFYKIEEALFFVDVPGYGFAKVSKTEREKWGVMIETYITSREQLRGVIQIVDLRHKPTEDDRMMYEFLKYYDIPVIVVATKADKIPRSKWQKNAKIVRETLDFDPDDKFVLFSSETKMGKDEAWQFIKEGME
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: IF2_SODGM
Sequence: MTDVTVKSLAAEIQTPVDRLVQQFADAGIDKTAVDSVTQQEKETLLAHLNRDRGAAPNKLTLQRKTRSTLNIPSTGGKSKSVQIEVRKKRTYVQRDPQAQEQAEAEEQARREAEELAQHQVQRDAEEKAKRAAEDKAKREAAEQAKRVAAESDKLTNQQTNTMTKSPQATEKARREAEAAELRRKAEEETRRKVEEKARQVAEEARRMAEERGGNWDNAPEPAEEDTTDYHVNTSHHAREAEDENDRKVEGDRRSRTRGGKATKQKKTSRLSESKADREEARAVGRGGKGKRRPSTLTQGFNKPAQAVNRDVVIGETITVAELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEESVMSDRDTGSSAAAESRAPVVTIMGHVDHGKTSLLDYIRSTKVAAGEAGGITQHIGAYHVETDNGMITFLDTPGHAAFTAMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAKVPVVVAVNKIDKPEADPDRVKNELTQYGVIPEEWGGESQFVHVSAKSGAGIDELLDAILLQAEVLELKAIRNGMASGVVIESFLDKGRGPVATVLVREGTLNRGDIVLCGFEYGRVRAMRDEVGRDVASAGPSIPVEILGLSGVPAAGDEATVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVSELNIVLKSDVQGSAEAISDALEKLSNDEVKVKIVGSGVGGITETDATLAAASNAILLGFNVRADASARRVIEAENLDLRYYSVIYDLIDEVKQAMSGMLAPEYKQEIIGLAEVRNVFRSPKFGAIAGCMVTEGVVKRHNKIRVLRENVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRSGDVIEVFETIEIQRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPRC_HUMAN
Sequence: MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI
What is the function of this protein?
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines.  Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes.  There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
What are the official names of this protein?
SPARC, Basement-membrane protein 40, BM-40, Osteonectin, ON, Secreted protein acidic and rich in cysteine.
What is the protein family that this protein belongs to?
Belongs to the SPARC family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.