PharMolix/UniProtQA huggingface dataset:
Protein: ABDH_SALTI
Sequence: MQYQLLINGVLVDGEGERQSVYNPATGEVILEIAEASPVQVDAAVLAADSAFAEWGQTTPKARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAARCLSGLAAGEYLEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLAALAKDIFPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTAPAIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALVEKLGNAVSSLKMGAPEDKSTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEGKGYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDVGRAHRLSARLQYGCTWINTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: CEBPA_RAT
Sequence: MESADFYEAEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSAGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQPPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPAMGAAGLPGPGGSLKGLAGPHPDLRTGGGGGGGAGAGKAKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA
What is the function of this protein?
Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.
What are the official names of this protein?
CCAAT/enhancer-binding protein alpha, C/EBP alpha.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. C/EBP subfamily.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleolus.
Protein: SSRP_STRMK
Sequence: MSKNSGKDKAKSATANKTIALNKRARHEYHIEERFEAGLALQGWEVKSIRAGRGNIIDAYAYVKHGEIFLIGAQITPLIQASTHVVANDRRERKLLLHRSEIDKLVGKVERDGYTIVPTAMYWSKNKIKLEVALAKGKQTHDKRDAAKDRDWAIEKQRVMRRGNRDA
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SULA_SERMA
Sequence: MRTQSLYQPHFGHGSYTTRNVAKNTDIGKENGLISELVYNERQPAVAQLLLPLLLQLGKQSRWLLWLTPQQKLSKQWLQQSGLPVDKMVQLSQISPVNTVEAMEKALQTGNYSVVLGWLPELTEEDRLKLRRAAELGNAYGFIMRPQRDISPTHGHCSTLKIHSSLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: GLMU_CELJU
Sequence: MLDILILAAGKGTRMRSDLPKVLHPIGGKPLVQHVVDTARQVGGEQLLLIVGHGAEQVEQRMAAPDVKFVVQAQQLGTGHAVQQALPHLRPEATVLILYGDVPLTRAATLQKLVAGVTDQQMALLTVDLPDPSGYGRIVRDTSGAVVAIVEHKDASDEQRLICEINTGIMAVKARHLQQWLPRLGNNNAQGEYYLTDIIAMAKADGVAIHVEQPGAIQEVEGINNRQQQATLERYYQQQQARALMDAGVTLLDPARFDCRGNLSAGRDVVIDINCVIEGEVVLGDGVVIEPNCIIINSKIGNNTHIKAFSHIEDAVIAADCDIGPYARLRPGTNLADAVKIGNFVETKKAVIAKGSKVNHLSYIGDARVGSGVNVGAGTITCNYDGVNKFKTEIGDNAFIGSNSALVAPVNIGAGATVGAGSVITRDVDAAELAVARGKQRNIQGWERPTRKS
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYW5_DANRE
Sequence: MDCQEKLEVPVYTDVDKETFLRDIYPQRRPAVLKRVPIGPCVRTWTVCFLAEKGGDREVKVHVSPEPRMDFLHKNFVYRTLPFDEFIKRAAEAKHPEFFISEDESYYLRSLGEDARKEPADLRKQFPELAEDFHVPQFFEPEQFFSSVFRISSPGLQLWTHYDVMDNLLAQVTGKKRVVLYSPEDALHLYLTGDKSEVLDIDSPDLQLYPEFVKARRYECILEPGDLLFIPALWFHNTLALQFGVGVNVFWRHLPSESYDKKDPYGNKDPVAATRALQSLERTLGILDELPPDYRDFYARRMVLRIQSRAYIRKPINAAQENSDTT
What is the function of this protein?
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.  Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*).  OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4.  OHyW is a derivative of wybutosine found in higher eukaryotes.
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 5, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the TYW5 family.
Protein: TRUA_SYNS9
Sequence: MTAEPSSAPPEQPILRRIALSLQYEGSDFCGWQRQNNARSVQAVLETAIAQLDPLRPIQSFAAGRTDAGVHAAAQVVHFDCSGPIPAAKWAPALNGRLPASIRVRESVERPRDWHACYSAVYRRYRYIIHNGRRPNLFLTPWTWHRYHHRLNEENMRVALEGMIGLHDFAAFMRAGSRRPHSRTTIQDVLVEREGDLIRVEIQASGFLYGMVRLLMAQLVAVGEHRLSVKAFEQRWRDRRRDQVREAAPARGLCLLRAGYAEPIFSEAGWYDCQPWFSLATDDPPPDPPCFAKDEQQELQ
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: CKLF3_HUMAN
Sequence: MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYVASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITAIAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSDSD
What are the official names of this protein?
CKLF-like MARVEL transmembrane domain-containing protein 3, Chemokine-like factor superfamily member 3.
What is the protein family that this protein belongs to?
Belongs to the chemokine-like factor family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS14_ECO24
Sequence: MAKQSMKAREVKRVALADKYFAKRAELKAIISDVNASDEDRWNAVLKLQTLPRDSSPSRQRNRCRQTGRPHGFLRKFGLSRIKVREAAMRGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: GATC_AQUAE
Sequence: MVDREWVLKIAKLARLELKEEEIEVFQKQLSDILDFIDQLKELDTENVEPYIQEFEETPMREDEPHPSLDREKALMNAPERKDGFFVVPRVVEV
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: NU2C_PROM2
Sequence: MPNEIFTINLNAQAIIPEAFILLGIVGTLLVDLAGEKTASKWAPIICYLSIGSSLLSLALQWSNPVESAFLGSFNSDNLAISFRAIISLSTLVSLLISWRYTEQSGSPIGEFAAIVLSATLGAMLLCGSTDLISVFISLETLSVASYLLSGYLKRDPRSSEAALKYLLVGSAAAAVYLYGSSFLYGLSGSTNLATIGLEIINKPSFITSLALVFVLSTVAFKIAAVPFHQWTPDVYEGSPTPVVAFLSVGSKTAGFAFAIRILSTTFSSFDEEWKLLFTILAILSMALGNVVALAQTSMKRMLAYSSIGQAGFVMIGIVSGTQDGLSAAVLYLAAYLFMNLGAFSCVILFSLRTGSDRILDYSGLYQKDPLITLGLSLCLLSLGGLPPMLGFFGKIYLFFAGWANHQYLLVIVGLVTSVISIYYYISVIKMMVVKEPQEASEIVKSYPEINWGIVGLPPLRVALYTCVAVTALGGILSNPLFKLANTAVSETPFLQDIIATANNIS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2, NAD(P)H dehydrogenase subunit 2, NADH-plastoquinone oxidoreductase subunit 2, NDH-1, subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: SYW_STAAM
Sequence: METLFSGIQPSGIPTIGNYIGALKQFVDVQNDYDCYFCIVDQHAITMPQDRLKLRKQTRQLAAIYLASGIDPDKATLFIQSEVPAHVQAGWMLTTIASVGELERMTQYKDKAQKAVEGIPAGLLTYPPLMAADIVLYNTNIVPVGDDQKQHIELTRNLVDRFNSRYNDVLVKPEIRMPKVGGRVMSLQDPTRKMSKSDDNAKNFISLLDEPNVAAKKIKSAVTDSDGIIKFDRDNKPGITNLISIYAGLTDMPIKDIEAKYEGEGYGKFKGDLAEIVKAFLVEFQEKYESFYNSDKLDDILDQGRDKAHKVSFKTVKKMEKAMGLGRKR
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_GUITH
Sequence: MNEQEIFEKVQTIISEQLGVDKSQVTKDANFANDLGADSLDTVELVMAIEEAFNIEIPDDAAEQISNLQQAVDFISQKVAA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PYRE_HAEI8
Sequence: MEQYKRDFIEFALSRNVLKFGEFTLKSGRKSPYFFNAGLFNTGADLARLGEFYAAAIQASAVDFDVVFGPAYKGIPIGTSVSVALFNRYGIDKPVCFNRKEVKDHGEGGNLIGSPLQGKILLVDDVITAGTAIRESMELISANKAELAAVLIALNRKERGKGELSAIQEVERDYQCQVLSIIDLDDLMQFIEQDPRYSSHLPEMRAYRAEFGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: E310_ADE03
Sequence: MIPRNFFFTILICPFNVCATFTAVATASPDCIGPFASYALFAFVTCICVCSIVCLVINFFQLVDWIFVRIAYLRHHPEYRNQNVAALLRLI
What is the function of this protein?
Down-regulates the EGF receptor.
What are the official names of this protein?
Early E3B 10.4 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E3B family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: DNJB5_MOUSE
Sequence: MGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRSLYDQYGEEGLKTGGGSSGGSGGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSTRPFSGFDPDDMDVDEDEDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS
What are the official names of this protein?
DnaJ homolog subfamily B member 5, Heat shock protein Hsp40-3, Heat shock protein cognate 40, Hsc40.
Protein: NORM_XYLFT
Sequence: MFLPRPDFRIALSICFMAVSFVISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALLWLPMLVPMGTLISLTVLVSQLHGAERERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLPLFGIVPDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMHCTFPTMLLGFGGLLVLVPLSYALTYGRFGFAEYGVEGLGIATVTVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARIRDLLNIGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEATTVRIGHAVGRCDLLVMRRVAWAGYAIVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLASKLLLFAAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISYWGLGMPLGLGLGFALEWNSRGMWIGLIIGLTAAALLLGWRFRVVSERMFAGIP
What is the function of this protein?
Multidrug efflux pump.
What are the official names of this protein?
Probable multidrug resistance protein NorM, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y663_CHLTR
Sequence: MLEKLIKNFVAYMGVASELEFDADGSYVFPISSLVRMRVRQNADEEIIISAFLGEIPASMDIEKAYARMMEGNLFGQETGGAALGLDSDGHAVLVRRVPGEVSQEDFASYIESVLNYAEAWLEDLGLSKTEQE
What are the official names of this protein?
Uncharacterized protein CT_663.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0713/CT_663/TC_0034 family.
Protein: ENO_ORYSJ
Sequence: MAATIVSVKARQIFDSRGNPTVEVDVCCSDGTFARAAVPSGASTGVYEALELRDGGSDYLGKGVSKAVDNVNSVIAPALIGKDPTSQAELDNFMVQQLDGTKNEWGWCKQKLGANAILAVSLAICKAGAIIKKIPLYQHIANLAGNKQLVLPVPAFNVINGGSHAGNKLAMQEFMILPTGAASFKEAMKMGVEVYHNLKSVIKKKYGQDATNVGDEGGFAPNIQENKEGLELLKTAIEKAGYTGKVVIGMDVAASEFYNDKDKTYDLNFKEENNDGSQKISGDSLKNVYKSFVSEYPIVSIEDPFDQDDWEHYAKMTAEIGEQVQIVGDDLLVTNPTRVAKAIQEKSCNALLLKVNQIGSVTESIEAVKMSKRAGWGVMTSHRSGETEDTFIADLAVGLATGQIKTGAPCRSERLAKYNQLLRIEEELGAAAVYAGAKFRAPVEPY
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase, OSE1.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_STAES
Sequence: MARREEETKEFEERVVTINRVAKVVKGGRRFRFTALVVVGDKNGRVGFGTGKAQEVPEAIKKAVEAAKKDLVVVPRVEGTTPHTITGQYGSGSVFMKPAAPGTGVIAGGPVRAVLELAGITDILSKSLGSNTPINMVRATINGLQNLKNAEDVAKLRGKSVEELYN
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RS21_SYNS9
Sequence: MSQVTVGENEGIESALRRFKRSVAKAGIFSDLRRIRHHETPVEKYKRKLKQRSRNRRR
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: BX2_LOXGA
Sequence: VDKRRPIWVMLLSSYWQDGNSLGVDAIMTNYPEDVK
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LgSicTox-beta-LOXN2, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KPYM_RAT
Sequence: MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
What is the function of this protein?
Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth.  In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.
What are the official names of this protein?
Pyruvate kinase PKM, Pyruvate kinase muscle isozyme, Threonine-protein kinase PKM2, Tyrosine-protein kinase PKM2.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
What are the subcellular locations of this protein?
[Isoform M2]: Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli. SUBCELLULAR LOCATION: [Isoform M1]: Cytoplasm.
Protein: SECA_RICB8
Sequence: MFSILKKIFGTANDRTIKKLFSDIAKINSLEPAIQKLSDEELKNKTVEFKKKLKNGATLDDIAYEAFAVVREASRRVYGMRHFDVQLIGGLVLHRGMITEMRTGEGKTLVATLPAYLNALAEKGVYVVTVNDYLVSRDSASMGKIYNFLGLSVGCIVAGMTDEAKREAYNSDITYATNNELGFDYLRDNMKYSLQERVLRPFNFAIIDEVDSILIDEARTPLVISGPVNDNSELYGKVDKLVRMLNVSDFEKDEKLKTINLTESGISHVESLLSQADIIKPNSGLYDFENLSLVHYVNQALRAHNMFMIDVDYLVRDGKVMIIDEFTGRVMEGRRYSEGLHQALEAKENVKIQNENQTLASITFQNYFRNYPKLSGMTGTAMTEAPELKDIYNLDVVAVPTHNKVTRRDLDDEIYGSKKEKYDAILKLIKDCYDRGQPVLVGTVSIEKSEEISNVLNKNKIPHKVLNAKFHEQEAFIIAQAGRFKAVTIATNMAGRGTDIMLGGNPEMLIEQIDRKSLTNAAYKEKVNEIKAQTAEEKKQVIAAGGLFVIGTERHESRRIDNQLRGRSGRQGDPGNTKFFLSLDDDLMRIFASERISGVLRTLGLKDGEAIHHPMISRSLEKAQQKVEGHNYEIRKNLLRFDDVMNDQRKIIYEQRTEIIKSKDSYDFLSSTTEELAKKIVLTFMPAGSYREDWDIENLSVELHRTFAIKLDQNLISKNDVTEEEVTKIVIQTADSIYKSKEEAYSPDLMHNAVKYILLTTLDQVWKDHLHSLDHLRQGISLRAYAQKDPLSEYKREAFNLFEHMLNNLKELFIQTVYHFHIDLKHIQKEDISLENKKLQNNMHESREDPAFSKYNAGSNLETDLRPVISRINPEDRDPKNPTSWGKVSRNELCPCGSGKKYKYCHGLNE
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: BARD1_RAT
Sequence: MPRRPPRVCSGNKPPPVPAMEPATDGLWAHSRAALARLEKLLRCSRCANILREPVCLGGCEHIFCSGCISDCVGSGCPVCHTPAWILDLKINRQLDSMIQLYSKLQNLLHDNKGSDSKDDTSRASLFGDAERKKNSVKMWFSPRSKKIRCVVNKVSVQTQPQKAKDDKAQEASVFEFVSATPPVVVSTRAKTASRTSAKKHPKKSVAKINREGNFRPETRDSRFDSKEKLKEEKVVSFSQTLVMENSRVNGEIDLLASGSVVESVFSGSFAEVSLPLAEHIVSPDTVSKSEEAPEKKVCVEDRCPVGSDGNPKGCHRPPTSTSKKCGSNVPSASGEIREPTLLAENVVLVDCSSLPSGRLQVDVTLRRQSNASDDSLSLSPGTPPSLLNNSTHRQMMSKPSTVKLSSGIPARKRNHRGETLLHIASIKGDISSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKIVELLLQHNALVNTTGYHNDSPLHDAAKNGHIDIVKVLLSHGASRNAVNIFGERPVDYTDAENIRSLLLLPEKTDSFSTSQCSVQVNTGQRKSGPLVLIGSGLSSQQQKLLSKLETVLKAKKCAEFDNTVTHVIVPDEEAQSTLKCMLGILNGCWVLKFDWVKACLDSQEREQEEKYEVPGGPQRSRLNREQLLPKLFDGCYFFLGGNFKHHPKEDLLKLIAAAGGRILSRKPKPDSDVTQTINTVAYHAKPDSDQRFCTQYIVYEDLFNCHPERVRQGKVWMAPSTWLISCVMAFELLPLDS
What is the function of this protein?
E3 ubiquitin-protein ligase.  The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability.  Plays a central role in the control of the cell cycle in response to DNA damage.  Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function.  Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
What are the official names of this protein?
BRCA1-associated RING domain protein 1, BARD-1, RING-type E3 ubiquitin transferase BARD1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.
Protein: UPPP_ERWT9
Sequence: MTDIHQLWIAAILGLVEGLTEFLPVSSTGHMILVGHLLGFEGNKAETFEVVIQLGSILAVVVMFWRRLFGLIGIHFGEVPHEGSGQGRLTLIHILLGMVPAVVIGLLLHDQIKTLFNPVNVMYALVVGGVLLIAAELLKPKRPKSPGVDDITYRQAFMIGCFQCLALWPGFSRSGATISGGMLVGVSRYAASEFSFLLAVPMMIGATGLDLYKSMGFLSMADFPMFAVGFVTAFIVALIAIKSFLHIIKRISFIPFAIYRFIVAAAVYALFVL
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PLSY_PSET1
Sequence: MLATLMFILAYLLGSISSAILVSRLFKLPDPRSNGSNNPGATNVYRLGGALPACLVLIFDVLKGTIPVWGAYFLDLEPLALGLVAVAACLGHMFPLFFGFKGGKAVATAFGSLLPIGLSLAGLLICTWFIMVAITRYSSLAALVAVSLAPLYTWLIKPLYTLPVTFITVLIIFRHRSNIARLFSGNEPKVGAKKAPTDEKSDI
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.