PharMolix/UniProtQA huggingface dataset:
Protein: PCNB_ECOL6
Sequence: MFTRVANFCRKVLSREESEAEQAVARPQVTVIPREQHAISRKDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNVSDRTTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDGVIRLIGNPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLETAQKIAQESGLTYHDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAAYDLLALRAEVERNAELQRLVKWWGEFQVSAPPDQKGMLNELDEEPSPRRRTRRPRKRAPRREGTA
What is the function of this protein?
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay.  Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
What are the official names of this protein?
Poly(A) polymerase I, PAP I.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Protein: NANE_ECOLU
Sequence: MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANLQATRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLARIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLALVKTLSDAGCRVIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: RL20_NEIG1
Sequence: MPRVKRGVTARARHQKIFALAKGYRGRRKNVYRVAKQAVMKAGQYAYRDRRQRKRQFRQLWIVRINAGARENGLSYSKFMNGLKRASIEIDRKVLADLAVFDKAAFAQLVEKAKAALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: HEM3_PROM5
Sequence: MTKLKLKIASRRSKLAMVQTLWVKEQLEKNIPNLEVSIESMATQGDKILDVALAKIGDKGLFTKELEAQMLIGKADIAVHSLKDLPTNLPDGLKLGCITKREDPSDALVVNKKNEIYQLESLPAGSIVGTSSLRRLAQLRYKFPYLNFKDIRGNVITRIEKLDSGEFDCIILAAAGLKRLGFESRIHQIIPNEISLHAVGQGALGIECKSEDKEVLKIISVLEDKASSQKCLAERSFLRELEGGCQVPIGVNSSIQNDEICLKGMVASIDGKKLIKDESSGNVKYPEEVGKKLAEKLKLQGADKILSEIFEQFRDK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CTAA_ERYLH
Sequence: MALARWLWVVAGLVVTIVAIGGITRLTESGLSITHWSVVSGILPPLSESAWQAEFDLYRQTGEYRLESGPAGMDLAAFKFIYFWEWFHRILGRVIGLAFLLPMMWFWIRGMIPAGYRGRLLALFALICGQGALGWYMVASGVGTDLTDVSHFRLSAHLLTALFLLAGLVWTALDLRRLARVPDARPARFTGVAWMASIILFIQILLGAWVAGLNAGHASYSWPMMNGGLLPQPDLTRGWLWALTHDPFLLHFLHRWWAWVAVIALVVLARKVRPFDRRASIAVHSAFGTMVVLGIATVLSEVSLWIAVAHQLTGALLVISTAWAAHAIGTARKTEAA
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YCJF_ECOSE
Sequence: MTEPLKPRIDFDGPLEVDQNPKFRAQQTFDENQAQNFAPATLDEAPEEEGQVEAVMDAALRPKRSLWRKMVMGGLALFGASVVGQGVQWTMNAWQTQDWVALGGCAAGALIIGAGVGSVVTEWRRLWRLRQRAHERDEARDLLHSHGTGKGRAFCEKLAQQAGIDQSHPALQRWYASIHETQNDREVVSLYAHLVQPVLDAQARREISRSAAESTLMIAVSPLALVDMAFIAWRNLRLINRIATLYGIELGYYSRLRLFKLVLLNIAFAGASELVREVGMDWMSQDLAARLSTRAAQGIGAGLLTARLGIKAMELCRPLPWIDDDKPRLGDFRRQLIGQVKETLQKGKTPSEK
What are the official names of this protein?
UPF0283 membrane protein YcjF.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CESSA_CONBY
Sequence: MGRLTMALCWLLLLLLTTQACYITNCPRGGKRDVDDGLGVRPCMFCSFGQCVGPHICCGAGGCEIGTLEASTCHEENENPIPCHVFGDRCLLKHPGNVHGNCVSPGVCCTDDTCSMHVGCL
What are the official names of this protein?
Conopressin-conophysin.
What is the protein family that this protein belongs to?
Belongs to the vasopressin/oxytocin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDUB5_HUMAN
Sequence: MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRHSGDHGKRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTMAVLQIEAEKAELRVKELEVRKLMHVRGDGPWYYYETIDKELIDHSPKATPDN
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial, Complex I-SGDH, CI-SGDH, NADH-ubiquinone oxidoreductase SGDH subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFB5 subunit family.
Protein: YIHY_SALSV
Sequence: MLKTVHQKAGRHTRPVRAWLKLLWQRIDEDNMTTLAGNLAYVSLLSLVPLIAVVFALFAAFPMFSDVSIQLRHFIFANFMPATGDVIQRYIEQFVANSNKMTAVGACGLIVTALLLMYAIDSALNTIWRSKRTRPKVYSFAVYWMILTLGPLLAGASLAISSYLLSLRWASDLNTVIDNVLRILPLLLSWISFWLLYSIVPTTRVPNRDALVGAFVAALLFEAGKKGFALYITMFPSYQLIYGVLAVIPILFVWVYWTWCIVLLGAEITVTLGEYRKLKQAAEQEEADQP
What are the official names of this protein?
UPF0761 membrane protein YihY.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LRB4A_MOUSE
Sequence: MIAMLTVLLYLGLILEPRTAVQAGHLPKPIIWAEPGSVIAAYTSVITWCQGSWEAQYYHLYKEKSVNPWDTQVPLETRNKAKFNIPSMTTSYAGIYKCYYESAAGFSEHSDAMELVMTGAYENPSLSVYPSSNVTSGVSISFSCSSSIVFGRFILIQEGKHGLSWTLDSQHQANQPSYATFVLDAVTPNHNGTFRCYGYFRNEPQVWSKPSNSLDLMISETKDQSSTPTEDGLETYQKILIGVLVSFLLLFFLLLFLILIGYQYGHKKKANASVKNTQSENNAELNSWNPQNEDPQGIVYAQVKPSRLQKDTACKETQDVTYAQLCIRTQEQNNS
What is the function of this protein?
Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931).  Receptor for FN1 (PubMed:34089617).  Receptor for integrin ITGAV/ITGB3 (PubMed:11323698).  Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:8855262, PubMed:10026201, PubMed:11457897, PubMed:11323698).  Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301).  Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931).  Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239).  Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399).  Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414).  Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953).  Inhibits lysis by natural killer cells (PubMed:8977169).
What are the official names of this protein?
Leukocyte immunoglobulin-like receptor subfamily B member 4A, Mast cell surface glycoprotein Gp49B.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RPOC_STRPG
Sequence: MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPEREGLFDEVIFGPTKDWECACGKYKRIRYKGIVCDRCGVEVTRAKVRRERMGHIELKAPVSHIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEPKSLLTEREYREKLQEYGHGSFVAKMGAEAIQDLLKRVDLAAEIAELKEELKSASGQKRIKAVRRLDVLDAFNKSGNKPEWMVLNILPVIPPDLRPMVQLDGGRFAASDLNDLYRRVINRNNRLARLLELNAPGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLGKRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVAKEYAGNVKAAKRMVERGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNADFDGDQMAIHVPLSEEAQAEARLLMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEDAGREGEGMIFKDKDEAVMAYRNGYAHLHSRVGIAVDSMPNKPWKDNQRLKIMVTTVGKILFNDIMPEDLPYLQEPNNANLTEGTPDKYFLEPGQDIQEVIDGLEINVPFKKKNLGNIIAETFKRFRTTETSAFLDRLKDLGYYHSTLAGLTVGIADIPVIDNKAEIIDAAHHRVEEINKAFRRGLMTDDDRYVAVTTTWREAKEALEKRLIETQNPKNPIVMMMDSGARGNISNFSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIIREDDCGTDRGLLIRAITDGKEVTETLEERLQGRYTRKSVKHPETGEVLIGADQLITEDMARKIVDAGVEEVTIRSVFTCATRHGVCRHCYGINLATGDAVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRIQEIFEARNPKGEAVITEVKGNVVEIEEDASTRTKKVYVQGKTGMGEYVVPFTARMKVEVGDEVNRGAALTEGSIQPKRLLEVRDTLSVETYLLAEVQKVYRSQGVEIGDKHVEVMVRQMLRKVRVMDPGDTDLLPGTLMDISDFTDANKDIVISGGIPATSRPVLMGITKASLETNSFLSAASFQETTRVLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNIEPQAMNEIEVIDHTEVSAEAVFTAEAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: KA122_YEAST
Sequence: MSSIHEVVALIEELYSPHPKHDVNQIQQSLQSIQKSEQGFHLANELLSDDKYSANVKYFGALTLTVQLNTRGENDYETLWNVFRSNLLYLTKFSTLYVSNPNMYGQSLIIIKKLMSNLSLIFTKINDPQLNNAGNENMIKQWNNPINTFIQLMSVQNQNINADQLLLDSINCSLTYEQLSQFVSLSQKHNELALTFTEVIVEDLTKFQTKRHSMSQIHEVVHEHLYISTMALINLNLTAQAVFNPTVFDCITAWINYISLTRSVSSSGRMDLSEIFQNLIDLMYQSTEGSDGYENAEKILTIFGNVFANDPLLMSYDLRQQIECIFLGVVRPDSGITDISNKNSWMLQYMNYLVTNDFFSELKELAICIVDFLQINTLSVCNKLFTNIQAADNGQVQDEYIQEYIKVLLQMTNFPLTPVLQEFFSVRMVDFWLDLSDAYTNLASETLRPNSIELSTQIFQQLINIYLPKISLSVKQRIIEEEGESTSVNEFEDFRNAVSDLAQSLWSILGNDNLTNVLIDGMGQMPAASDETLIIKDTDVLFRIETMCFVLNTILVDMTLSESPWIKNIVDANKFFNQNVISVFQTGFQTSASTKVSQILKLDFVRTSTTLIGTLAGYFKQEPFQLNPYVEALFQGLHTCTNFTSKNEQEKISNDKLEVMVIKTVSTLCETCREELTPYLMHFISFLNTVIMPDSNVSHFTRTKLVRSIGYVVQCQVSNGPEEQAKYILQLTNLLSGSIEHCLASSVQLQEQQDYINCLLYCISELATSLIQPTEIIENDALLQRLSEFQSFWSSDPLQIRSKIMCTIDKVLDNSIYCKNSAFVEIGCLIVGKGLNLPDGEPYFLKYNMSEVMNFVLRHVPNCELATCLPYFVYLLEKLISEFRKELTPQEFDFMFEKILLVYYDAYIINDPDLLQMTIGFVNNVLDVKPGLAIGSKHWTSFILPQFLKLIPSREKFTIVAVAKFWTKLINNKKYNQEELTTVRQQVSSIGGDLVYQIMYGLFHTQRSDLNSYTDLLRALVAKFPIEAREWLVAVLPQICNNPAGHEKFINKLLITRGSRAAGNVILQWWLDCTTLPNYQG
What is the function of this protein?
Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm.  Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA).  Required for the nuclear import of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR).  May play a role in regulation of pleiotropic drug resistance.
What are the official names of this protein?
Importin beta-like protein KAP122, Karyopherin-122, Pleiotropic drug resistance regulatory protein 6.
What is the protein family that this protein belongs to?
Belongs to the importin beta family.
What are the subcellular locations of this protein?
Nucleus envelope.
Protein: PUR7_CROS8
Sequence: MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTEALVKKLDMVPVECVIRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSQENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLFKGEVTLGDEFSPDGARLWDKQTMDKMDKDRFRQSLGGLIEAYEEVARRLGVNLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: SFSA_THISH
Sequence: MEFEPALIEVTLLRRYKRFLADVRTPDGREFTAHCPNTGSMMGCMEPGSRVWLSHSPDPKRKYAHTWQLVEAEGALVGINTGLSNRLVEEAIGSGLIAELAGWPGLRREVRYGDQGSRIDLLLEDGERRCYVEVKNVTAAVSEGVAIFPDAVSARGSKHLEELMLMVREGHQAALVFCVQRGDVHTVRPADAIDPLYGQRLREAAQAGVRVLACGARVWPGGVVLERVLDVDLSRAG
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: MINE_HYDCU
Sequence: MALLDYLLGQKKKKSANLAKDRLQILLAHERSERSAPEYLPKMREEILAVISKYVTIDQEQLQISIDEANGFEVLELNLVLPDK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RAD50_METKA
Sequence: MIERVKIENLRSHSSTEIEFREGINVLVGPNGAGKTTVLEAITLALFPRTFRSYDHMIREGERRAVVEVVFWGADGHKYKVRREFYRGGGQRNPRLYREEGDGWKVVASGRAEDVDREVMNALGGVDRDVFREAVYIRQGEIAKLVEATREERKRIVDRTLGLAEFKKAREQAHELLRVAEAKLETFRERVRDLKGSKKELKRVERELEELKREVKELEPEVEELKERLNELREAKREFERLEGELRLLENKIESLKGRRDDLRKLVEEGKEAERELQRLGDVPSKVRELENEEAELRRRIEELRNLLDDLRSLRNRLESAEEELEGVKRELEELKDEAGVDPERLVEFKDKIVEASERLRDLRREEELKRKLEKVSDELSELGDREETLQSEYEELQERLDEIQGELKEIRVKEKELLERIESLREAEGECPVCLRKLPRERAEKLLRDAEKELERLQGREEDLRKERRELKDRLESVRRELEGTKERMWRLRERREELERELEEIEELKEELADLSRELGVEEDRLPELRDLAVRAESLLRDLERRRGDVLRLEKELERTLDRCEKVIGRTPSGVEDVEEELRRLEEERDHVGQKLREAEGELERYHNLEEKVKRAREARKELKRIERDLEDAKGRLEQVERNLEGLRERYGSEDRLEEELESVEKKYERVRDKLSEVKGRLNGMEKRREELKKQVRKYREAKERKERLERVVEVLSLCKEVFRYSRDVAREKVLPAVEREASKILQDLSDRYGSLRIEDDGAVIRVSVPGGHFIEADRMSGGEKIIIGLALRLALAMVGSSFAPFIMLDEPTVHLDAEHRERLAQALRELDLGKGRVRQAIVVTHDEELEDAADELWRIENRAGESRVERYSG
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair.  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA.  Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
What are the official names of this protein?
DNA double-strand break repair Rad50 ATPase.
What is the protein family that this protein belongs to?
Belongs to the SMC family. RAD50 subfamily.
Protein: RLMH_ACET2
Sequence: MRITIIAVGKIKEKYLKEGINEYSKRLSRYCKLEIIEVEDEHAPDNLSSLEEQQVKKREAERVVKRLKEGTLLVVLDVRGSKMSSEELARKLESFFISGKSHVTFVIGGSLGIDKELLNMADFSLSLSDMTFPHQLTRLILLEQLYRSFKIINGEPYHR
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_BACHK
Sequence: MSIPNNLRYSEEHEWVKTEGNEVVIGITHFAQNELGDIVFVELPEVGATIEADEPFGSVESVKTVSELYAPVSGKVVAVNEELSDQPELVNESPYEGAWMVKVELSDASQVEKLLTAEKYAEMTNQD
What is the function of this protein?
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
What are the official names of this protein?
Glycine cleavage system H protein, Octanoyl/lipoyl carrier protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RS14_YERPN
Sequence: MAKQSMKAREVVRVKLANKYRAKREELKAIISGVNSSDEDRWDAVLKLQSLPRDSSPSRQRNRCNQTGRPHGFLRKFGLSRIKVRETAMRGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RSBW_LISMH
Sequence: MATMHDKITLQLPAKPEYVSLGRLSLSGIASRAGFSYEAIEDLKIAVSEAITNSVKHAFKGEDDGEITVEYLIYEDKLEVRVSDNGTSFDLETRKQEIGPYEVGEDAEMMRIGGLGLFLIETLMDDVKLYYDEGVSVVMTKYINEKQVEENAKSIST
What is the function of this protein?
Negative regulator of sigma-B activity.  Phosphorylates and inactivates its specific antagonist protein, RsbV.  Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
What are the official names of this protein?
Serine-protein kinase RsbW, Anti-sigma-B factor, Sigma-B negative effector RsbW.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: LSP1_HUMAN
Sequence: MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAGRTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP
What is the function of this protein?
May play a role in mediating neutrophil activation and chemotaxis.
What are the official names of this protein?
Lymphocyte-specific protein 1, 47 kDa actin-binding protein, 52 kDa phosphoprotein, pp52, Lymphocyte-specific antigen WP34.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SC6A6_MOUSE
Sequence: MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLSLSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFVFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMLCIPLVIVILLCRTEGPLRVRIKYLITPREPNRWAVEREGATPFHSRVTLMNGALMKPSHVIVETMM
What is the function of this protein?
Mediates sodium- and chloride-dependent transport of taurine (PubMed:1465453, PubMed:9375654, PubMed:30270321).  Can also mediate transport of hypotaurine, beta-alanine and gamma-aminobutyric acid (GABA) (PubMed:1465453, PubMed:9375654, PubMed:30270321).
What are the official names of this protein?
Sodium- and chloride-dependent taurine transporter, Solute carrier family 6 member 6.
What is the protein family that this protein belongs to?
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KDPC_BACAC
Sequence: MAKKQSILSPIIRITFTFLVLCGLVYPLIVTGIAQAVMKDNADGSLIYNDKNEVIGSKLIGQNFTDPRYFHGRVSSIEYKAEASGSNNYAPSNPDLEKRVEKSIEEWKKQNPSVPVTEVPIDLVTNSGSGLDPDISPKAASVQVERISKLTNIPKETLDQLIKDQTEGAALGLFGETRVNVLKLNLGLQKIMK
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: DIAA_ECO7I
Sequence: MQERIKACFTESIQTQIAAAEALPDAISRAAMTLVQSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDV
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: 3SP1_DENJA
Sequence: RICYNHLGTKPPTTECTQEDSCYKNIWRNITFDNIRRGCGCFTPRGDMPGPYCCESDKCNL
What is the function of this protein?
Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen.
What are the official names of this protein?
Toxin S5C1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Antiplatelet toxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL11_CANGA
Sequence: MSAKTQNVMRELKIEKLVLNISVGESGDRLTRASKVLEQLSGQTPVQSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRNRNFSTTGNFGFGIQEHIDLGIKYDPSIGIFGMDFYIVMGRPGNRIARRKRCRATVGNSHKTSKEDTIAWFKQRYDADVLDK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: DEOC_STRPC
Sequence: MEVKDILKTVDHTLLATTATWPEIQTILDDAMAYETASACIPASYVKKAAEYVSGKLAICTVIGFPNGYSTTAAKVFECEDAIQNGADEIDMVINLTDVKNGDFDTVEEEIRQIKAKCQDHILKVIVETCQLTKEELIELCGVVTRSGADFIKTSTGFSTAGATFEDVEVMAKYVGEGVKIKAAGGISSLEDAETFIALGASRLGTSRIIKIVKNEAIKTDSY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.