PharMolix/UniProtQA huggingface dataset:
Protein: TCTP_BOVIN
Sequence: MIIYRDLISHDEMFSDIYKIREVADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKC
What is the function of this protein?
Involved in calcium binding and microtubule stabilization (By similarity).  Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (By similarity).
What are the official names of this protein?
Translationally-controlled tumor protein, TCTP.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIGB_ECOSM
Sequence: MKVWMAILISILCWQSSAWAVCPAWSPARAQEEISRLQQQIKQWDDDYWKEGKSEVEDGVYDQLSARLTQWQRCFGNETRDAMMPPLNGAVMHPVAHTGVRKMADKNALSLWMRERSDLWVQPKVDGVAVTLVYRDGKLNKAISRGNGLKGEDWTQKVRLISAVPQTVSGPLANSTLQGEIFLKRKGHIQQQMGGINARAKVAGLMMRQGNSDTLNSLAVFVWAWPDGPQLMTDRLKELATAGFTLTQTYTRAVKNADEVAHVRNEWWKAKLPFVTDGVVVRAAKEPESRHWLPGQAEWLVAWKYQPVAQVAEVKAIQFAVGKSGKISVVASLAPVMLDDKKVQRVNIGSVRRWQEWDIAPGDQILVSLAGQGIPRIDDVVWRGAERTKPTPPENRFNSLTCYFASDVCQEQFISRLVWLGSKQVLGLDGIGEAGWRALHQTHRFEHIFSWLLLTPEQLQNTPGIAKSKSAQLWHQFNLARQQPFTRWVMAMGIPLTRAALNASDERSWSQLLFSTEQFWQQLPGTGSGRARQVIEWKENAQIKKLGSWLAAQQITGFEP
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Protein: SRP19_META3
Sequence: MKEIIIWSAYLDAEKSRKEGRKIPKELCVNNPKIKDIYNSLRKLGYNAEIVKNKCHPKEWWEIVGYIKVKVNDDIPKLEILKKICENLKK
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y843_STRU0
Sequence: MYAVKLNKDTLLPREKLVQYGVEQLSHQELLAILLRTGNKEKHVMELASHILHCLESLADFDKLSLQELQQLPGIGKVKAIELKAMVELCHRIQKAKSSHSIQILSSYQVAKRMMHELGDKKQEHLIAIYLDTQNRIIEEKTIFIGSVRRSIAEPREILHFACRNMATSLIVVHNHPSGLTNPSENDVAFTKKIKRSCDHLGINCLDHIIVGKKQYYSFREKSDIF
What are the official names of this protein?
UPF0758 protein SUB0843.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: TM241_XENLA
Sequence: MYFRGPAVGLTFCCFYLSSYFTNKYVLSVLKFTYPTLFQGWQTLVGGLILHICWKVGWLEINCNSRSDVVLWLPGCALFVGIIYAGSRALSRLPIPVFFTLHNAAEVVSYGFQRLLFREKCPYSKIFSIFLLLLSAGCLPLHDPQFDADGYFWAVIHLFCVGCYKVFKKSQKSGSLSDLDQQYINYVFSVVLLGLASHPTGDLISALEFPFLYFYRFHSGCCASGILGFLLMLASVKLRSNLSSVQHASWNFVAKVITAGLSLIYFQITLTVPLTLCLLAGGLGEAVLVYAERTGV
What are the official names of this protein?
Transmembrane protein 241.
What is the protein family that this protein belongs to?
Belongs to the TMEM241 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL28_LIMRJ
Sequence: MAKDFINGKRTQFGNKRSHALNSSRRSWKPNLQKVTILVNGKPKKVYVSARTLKSGKVTRV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: PSBA_DAUCA
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEAPSTNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SSRP_HAES1
Sequence: MTKKKAKVASNTIALNKRARHDYFIEDEIEAGLSLQGWEVKSMRAGKASIGDSYIIFKHGEAYLFGATIQPLSVASTHIVCDPTRTRKLLLNQKELASLFGKANRDGFTIVALSLYWKGPWAKVKIGLAKGKKLHDKREDIKDREWKVTKDRIMKNAQRG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ISPG_BACC4
Sequence: MNEMTHRTKTRPVKVGNLTIGGNNELIIQSMTTTKTHDVEATVAEIKRLEEAGCQVVRVAVPDERAADAIADIKKQINIPLVADIHFDYRLALKAIEGGIDKVRINPGNIGRRHKVEAVVNAAKERGIPIRIGVNAGSLERHILEKYGYPTADGMVESALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAARAFDYPLHLGITESGTLFAGTVKSAAGLGAILNKGIGNTLRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRIEIDLISIANEVEEYISTLQVPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGQVVRKVPEETMVEELKKEIDVIAAEMAAEREKEKETQEQ
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: 73C10_BARVU
Sequence: MVSEITHKSYPLHFVLFPFMAQGHMIPMVDIARLLAQRGVKITIVTTPHNAARFENVLSRAIESGLPISIVQVKLPSQEAGLPEGNETFDSLVSTKLLVPFFKAVNMLEEPVQKLFEEMSPQPSCIISDFCLPYTSKIAKKFNIPKILFHGMCCFCLLCMHVLRKNREILENLKSDKEHFVVPYFPDRVEFTRPQVPLATYVPGEWHEIKEDMVEADKTSYGVIVNTYQELEPAYANGYKEARSGKAWTIGPVSLCNKVGADKAERGNKADIDQDECLKWLDSKEEGSVLYVCLGSICSLPLSQLKELGLGLEESQRPFIWVVRGWEKNKELLEWFSESGFEERVKDRGLLIKGWSPQMLILAHHSVGGFLTHCGWNSTLEGITSGVPLLTWPLFGDQFCNQKLVVQVLKVGVSAGVEEVTNWGEEEKIGVLVDKEGVKKAVEELMGESDDAKEIRKRVKELGQLAHKAVEEGGSSHSNITSLLEDIMQLAQPNN
What is the function of this protein?
Catalyzes the transfer of a glucose (Glc) moiety from UDP-Glc to the C-3 position of the oleanane sapogenins oleanolate and hederagenin, and to the C-28 carboxylic group of the lupane sapogenin betulinate (PubMed:23027665).  The monoglucosylated hederagenin 3-O-beta-D-glucoside is a feeding deterrent of the yellow-striped flea beetle (Phyllotreta nemorum) (PubMed:23027665).
What are the official names of this protein?
UDP-glycosyltransferase 73C10, Oleanolate 3-O-glucosyltransferase UGT73C10.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: SUNT_BACSU
Sequence: MNKKKKYVHTKQFNSHDCGLACISSILKFHNLNYGIDFLLDLIGDKEGYSLRDLIVIFKKMGIKTRPLELQENKTFEALKQIKLPCIALLEGEEYGHYITIYEIRNNYLLVSDPDKDKITKIKKEDFESKFTNFILEIDKESIPEKEKDQKKHSYFFKDILFRNKLIVFVILLTSLFVVGLAVAGSFYIKFLVDLIIPRSLRESLITITLIFISMVLIRCIFDFVRSYLIIKLSYKVDKEMSNVYFNKVTKLPINFFENREDGEVISRFNDGIYIKDFFSANFVTAIIDIILILGLGVILYRTNNILFLTIILPILLLSCLAILFFDHLKKKNQKLMEDKAKSTSLLINFLKNMTTVYSLNKTSFFLEKFHLTYDKQLNSTFSVAKAVISNEILKGLIQNSFTIIILWVGTRQVLNDSMSLGTLLFINTLAAFLLSSLDRILSMQSDLQQAHVASIRFFDVVNYPVQQDSNENLTELDFIQNIKTVNLNIGADPMRYIVEDINLILDRKDKVLIIGESGTGKSTFAKSLSKLYKVPDKSIYLNGLDINRYDHLSIRKRIVYIDENPFLFKGTIKENLCMGEIFDQNEIENACIMSQCHEFICNLDKQYSYKLSENGSNLSTGQKQRLALARAILHQPQVLILDESLSNIDPDNTKLIYETLHRMDCLIILITHNDPSNFKYNKKLVFRNNRIIESSYSENKEYSI
What is the function of this protein?
SunT (TC 3. A. 1. 112. 4) is required for production of the lantibiotic sublancin-168, probably by both processing the signal peptide and exporting the resulting mature lantibiotic.
What are the official names of this protein?
SPbeta prophage-derived sublancin-168-processing and transport ATP-binding protein SunT.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. SunT family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KHSE_SALPB
Sequence: MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDVVSVEAADHFRLHNLGRFADKLPPEPRENIVYQCWERFCQALGKTIPVAMTLEKNMPIGSGLGSSACSVAAALVAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENGIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPQLAAALMKDVIAEPYRARLLPGFSQARQAVSEIGALASGISGSGPTLFALCDKPETAQRVADWLSKHYLQNQEGFVHICRLDTAGARVVG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_BACC4
Sequence: MQTMTIKEAENVLKEIMNEEDDRFQLLMKDDRKGVQKLVLKWYKQKELEQKEKEKFFEMSKYENALREKGITYIAGIDEVGRGPLAGPVVTAAVVLPEDFYIPGLNDSKKLSEAKRERFYDEIKVQAIAIGVGIVSPQVIDDINIYQATKQAMLDAVANLSCTPQHLLIDAMKLPTPIPQTSIIKGDAKSVSISAASIIAKVTRDRMMKELGEKYPEYGFEQHMGYGTKQHLEAIEVHGVLDEHRKSFAPIKDMIQK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLO2_ECOLU
Sequence: MNLNSIPAFDDNYIWVLNDEAGRCLIVDPGDAEPVLNAIAANNWQPEAIFLTHHHHDHVGGVKELVKKFPQIVVYGPQETQDKGTTRVVKDGEIAFVLGHEFSVIATPGHTLGHICYFSKPYLFCGDTLFSGGCGRLFEGTPSQMYQSLKKLSALPDDTLVCCAHEYTLSNMKFALSILPHDLSINDYYRKVKELRAKNQITLPVILKNERQINVFLRTEDIDLINVINEETLLQQPEERFAWLRSKKDRF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: HVM47_MOUSE
Sequence: EVQLQESGPSLVKPSQTLSLTCSVTGDSITSDYWNWIRKFPGNKLEHMGYISYSGSTYYNPSLKSRISITRDTSKNQYYLQLNSVTSEDTATYYCTSLRFAYWGQGTLVTVSA
What are the official names of this protein?
Ig heavy chain V region 36-60.
Protein: HIS2_BURCM
Sequence: MTQSTEDTLLRLAAVIDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQGGAPTALVGEVADLWFHCLVMLSHFDLSPADVIGELERREGLSGIEEKALRKRREREENGG
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHB8_HUMAN
Sequence: MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM
What is the function of this protein?
Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS).  Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis.  Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function (PubMed:19571038, PubMed:25203508, PubMed:30508570).  Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+) (PubMed:19571038).  Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (Probable) (PubMed:30508570).  NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2).  Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one).  Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol (PubMed:17978863).
What are the official names of this protein?
(3R)-3-hydroxyacyl-CoA dehydrogenase, 17-beta-hydroxysteroid dehydrogenase 8, 17-beta-HSD 8, HSD17B8, 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit, KAR alpha subunit, 3-oxoacyl-[acyl-carrier-protein] reductase, Estradiol 17-beta-dehydrogenase 8, Protein Ke6, Ke6, Short chain dehydrogenase/reductase family 30C member 1, Testosterone 17-beta-dehydrogenase 8.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: ALKL2_HUMAN
Sequence: MRGPGHPLLLGLLLVLGAAGRGRGGAEPREPADGQALLRLVVELVQELRKHHSAEHKGLQLLGRDCALGRAEAAGLGPSPEQRVEIVPRDLRMKDKFLKHLTGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPVCMEDKQ
What is the function of this protein?
Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation (PubMed:26418745, PubMed:26630010, PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673).  Cytokine-binding is sufficient to activate LTK (PubMed:34646012).  In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK (PubMed:34646012).  Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure (PubMed:34646012, PubMed:34819673).
What are the official names of this protein?
ALK and LTK ligand 2, Augmentor alpha, AUG-alpha.
What is the protein family that this protein belongs to?
Belongs to the ALKAL family.
What are the subcellular locations of this protein?
Secreted. Cell membrane. Note=Following interaction with receptor tyrosine kinase ALK, associates with the cell membrane, membrane-binding is required to activate ALK.
Protein: DRS1_LODEL
Sequence: MAKNEDLILTIDSDAEYDNISESSEEEAEEAVSVKSKKKNNNNNNNKKSKAGKHGKANLEEAEAEEDDDEARGEMNLDFQFSLGDDLNEIKDWEVEEPAKDIDLNEIIKKKRESKKDGNGDDEEDDGDEDEDASESEEDDEKEELKAAGKNGQAGDDDEDENEDEDEEEEVDTKEDLDNFYESQETNTSASALKSKTFQELQLSRPILKSLQQLGFTVPTPVQASTIPIALLGKDIVASAQTGSGKTAAYLIPIIERLLYVKNSTSTKAIILTPTRELAIQVHDVGRKLGQFVSNLNFGMAVGGLSLKQQEQQLKTRPDIVIATPGRLIDHIRNSPSFSVEDVQVLIIDEADRMLEEGFQEELTEILSLIPKQKRQTLLFSATMNNTKIQDLVQLSLNKPIKVSIDPPRTVASKLEQQFVRIRKREELKPAVLYLLLKKLEGRTVVFTRTKVEAHKLRIILGLLGLTVAELHGALTQEQRLANVKAFKNNVNVLICTDLAARGLDIRIEYVINYDMPKTYEIYTHRVGRTARAGRKGTSISFVGESMQDRNIVKNAIQFNSRSVARKIDWDEVEKIQTKIKLNEGAIEEVIEEEKQAREIMRAEMQLNKAENLMKYEKEIKSRPKRTWFKSEVMEHLTKHGKKVNAKKRKANEERKEEGKERSYKKTKADRTKLKTKAKSSSKKRK
What is the function of this protein?
ATP-binding RNA helicase involved in ribosome assembly.
What are the official names of this protein?
ATP-dependent RNA helicase DRS1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NCB5R_ASPCL
Sequence: MSALSSENVNGVYIPSALLVFGTFLVKKEFVPYAVALTAVLAGFKLFTGDSKARKVLNPTEFQEFVLKEKTDISHNVSIYRFALPRPTDILGLPIGQHISLAATIEGQPKEVVRSYTPISSDNEAGYFDLLVKAYPQGNISKHLTTLKVGDVMKVRGPKGAMVYTPNMCRHIGMIAGGTGITPMLQVIKAIIRNRPRNGGTDITKVDLIFANVNPEDILLKEELDKLAAEDEDFNIYYVLNNPPQGWTGGVGFVTPEMIKERLPAPASDVKVLLCGPPPMISAMKKATESLGFTKARPVSKLEDQVFCF
What is the function of this protein?
NADH-dependent reductase for dph3 and cytochrome b5.  Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase, predominantly cbr1.  By reducing dph3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex.  The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
What are the official names of this protein?
NADH-cytochrome b5 reductase 1, Microsomal cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: GRPE_BARBK
Sequence: MFDEKNKFTDASFENCDLKNPADRDTLKQAADELLKMHRGKEEVCADVEEEKNESTDLLATLQDENKELKDQFLRLAADMENLRRRTIRDVADAKIYSIANFARDMLSVSDNLNRALEAIPADARESDTNLKMLAEGVEMTERAMMAALEHHGVKKICPEGQKFDPNFHQAMFEISNSDVPDNTVQQVVQAGYIIGERVLRPAMVGVAKGGPKENSTEADSA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIGD_BACSU
Sequence: MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSRNGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRPDKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKETIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCITGFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPSICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIFEKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQSFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLMAVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTNAFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSSLTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS
What is the function of this protein?
The preference of the polymerase domain for rNTPs over dNTPs may be advantageous in dormant cells, where the dNTP pool may be limiting.
What are the official names of this protein?
Bifunctional non-homologous end joining protein LigD, NHEJ DNA polymerase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATP-dependent DNA ligase family.
Protein: IF11_CUPMC
Sequence: MAKEELIEFGGVVSEALPDNRYRVTLENGVEIWAYASGKMQKHRIRILAGDRVTLEMSPYDLTKGRINFRHKS
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBP3_WHEAT
Sequence: MATTPRLASLLLLLALCAAAAGALRLPPDASFPGAQAERLIRALNLLPGRPRRGLGAGAEDVAPGQLLERRVTLPGLPEGVGDLGHHAGYYRLPNTHDARMFYFFFESRGKKEDPVVIWLTGGPGCSSELAVFYENGPFTIANNMSLVWNKFGWDKISNIIFVDPATGTGFSYSSDDRDTRHDEAGVSNDLYDFLQVFFKKHPEFVKNDFFITGESYAGHYIPAFASRVHQGNKKNEGTHINLKGFAIGNGLTDPAIQYKAYTDYALDMNLIQKADYDRINKFIPPCEFAIKLCGTDGKASCMAAYMVCNSIFNSIMKLVGTKNYYDVRKECEGKLCYDFSNLEKFFGDKAVRQAIGVGDIEFVSCSTSVYQAMLTDWMRNLEVGIPALLEDGINVLIYAGEYDLICNWLGNSRWVHSMEWSGQKDFAKTAESSFLVDDAQAGVLKSHGALSFLKVHNAGHMVPMDQPKAALEMLRRFTQGKLKESVPEEEPATTFYAAI
What are the official names of this protein?
Serine carboxypeptidase 3, CP-WIII, Serine carboxypeptidase III.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
Protein: RNY_STRP8
Sequence: MVNIILLIVSALIGLILGYALISIRLKSAKEAAELTLLNAEQEAVDIRGKAEVDAEHIKKTAKRESKANRKELLLEAKEEARKYREEIEQEFKSERQELKQLETRLAERSLTLDRKDENLSSKEKVLDSKEQSLTDKSKHIDERQLQVEKLEEEKKAELEKVAAMTIAEAREVILMETENKLTHEIATRIRDAERDIKDRTVKTAKDLLAQAMQRLAGEYVTEQTITSVHLPDDNMKGRIIGREGRNIRTLESLTGIDVIIDDTPEVVILSGFDPIRREIARMTLESLIADGRIHPARIEELVEKNRLEMDNRIREYGEAAAYEIGAPNLHPDLIKIMGRLQFRTSFGQNVLRHSVEVGKLAGILAGELGENVALARRAGFLHDMGKAIDREVEGSHVEIGMEFARKYKEHPVVVNTIASHHGDVEPDSVIAVLVAAADALSSARPGARNESMENYIKRLRDLEEIATSFDGVQNSFALQAGREIRIMVQPEKISDDQVVILSHKVREKIEHNLDYPGNIKVTVIREMRAVDYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RS20_STRPM
Sequence: MEVKTLANIKSAIKRAELNVKANEKNSAQKSAMRTAIKAFEANPSEELFRAASSSIDKAESKGLIHKNKASRDKARLAAKLG
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: ACPS_STRZP
Sequence: MIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLKGRRQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLSISHTDQFVTASVILEENHES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.