Protein: UNC80_MOUSE
Sequence: MVKRKSSEGQEQDGGRGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFERVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSNRNKLGHQDKLGVAETKLLHTLHWMLLEAPQDCNNDQFGGTDRGSSWGGSSSAFIHQIENQGSPGQPCRSSSHDEEENNRRKTFQNSMATVELFVFLFAPLVHRIKESDLTFRLASGLVIWQPMWEHRQPEVSGFTALVKPIRNIITAKRSSPINSQSQTCESPNQDTRQQGEGLQVVSEALQSDSISPKATISGCHQGNSFDGSLSSQTSQERGPSHSRASLVIPPCQRSRYATYFDVAVLRCLLQPHWSEEGTQWSLMYYLQRLRHMLEEKPEKTPDPDIPLLPRPRSSSMVAAAPSLVNTHKTQDLTMKCNEEEKSLSPEAFSKVSLTNLRRSAVPDLSSDLGMNIFKKFKSRKEDRERKGSIPFHHTGKRRPRRMGVPFLLHEDHLDVSPTRSTFSFGSFSGLGEDRRGIEKGGWQTTILGKLTRRGSSDAATEMESLSARHSHSHHTLVSDLPDHSNSHGENTVKEVRSQISTITVATFNTTLASFNVGYADFFSEHMRKLCSQVPIPEMPHEPLACANLPRSLTDSCINYSYLEDTEHIDGTNNFVHKNGMLDLSVVLKAVYLVLNHDISSRICDVALNIVECLLQLGVVPCVEKNRKKSENKENESVEKRPSEGAFQFKGVSSSSTSGFGAPSASGAGDGGGEEGGGGDGGGGGGGGDGGGGGGGGGGPYEKNEKNQEKDDNIPVSNHRLALTMLIKIVKSLGCAYGCGEGHRGLSGDRLRHQVFRENAQNCLTKLYKLDKIQFRQTMRDYVNKDSLNNVVDFLHALLGFCMEPVTDNKAGFGNNFTTVDNKSTAQNVEGIIVGAMFKSLITRCASTTHELHSPENLGLYCDIRQLVQFIKEAHGNVFRRVALSALLDSAEKLAPGKKVEENGQESKPVGSKRSEAGSIADKGQVSSAPEECRSFMSGRPSQTPEHDEPMQGGNLGRKDFWRKMFKSQSAASDTSSQSEQDTSECTTAHSGNTSDRRARSRSRRISLRKKLKLPIGNWLKRSSLSGLADGVEDLLDISSVDRLSFIRQSSKVKFTSAVKLSEGGPGSGMENGREEEENFFKRLGCHSFDDHLSPNQDGGKSKNVVNLGAIRQGMKRFQFLLNCCEPGTIPDASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNITKKGLSRGRSPTVGNKRNQKLQWSAAKLFYQWGDAIGIRLNELCHGESESPANLLGLIYDEETKRRLRKEDEEEDFLDDSTVNPSKCGCPFALKMAACQLLLEITTFLRETFSCLPRPRTEPLVDLESCRLRLDPELDRHRYERKISFAGVLDENEDSKDSLHSSSHTIKSDAGAEEKKVPSRKIRIGGSRLLQIKGTRSFQVKKGGSLSSIRRVGSLKSSKLSRQDSESEAEELQLSQSRDTVTDLEGSPWSASEPSIEPEGLSNAGTEENYHRNMSWLHVMILLCNQQSFICTHVDYCHPHCYLHHSRSCARLVRAIKLLYGDSVDSLRESNHISNVALRGKKQKECSDKSCLRTPSLKKRVSDVNLEGKKDSGMLKYIRFQVMSLSPAPLSLLIKAAPILTEEMYGDIQPAAWELLLSMDEHMAGAAAAMFLLCAVKVPDAVSDMLMSEFHHAETVQRLNAVLKFHTLWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWVPQCSGSVQDPINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREASLITAIPITQEACYEPTCTPNSEPEEEEEVANLTSRRLSVSPSCTSSTSHRNYSFRRGSVWSVRSAVSAEDEEHATEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISNRQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVVGYVEGLFFKDLKQTMKKEQCEVKLLVTASMPGTKTLVVHGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDIYPFRRSVSPQLNLVHMHPEKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRSAIDAEFSLFSDPQAGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHFNHLFSLSGYQWILPTMLQVYSDYESNPQLRRAIEFACHQFYILHRKPFVLQLFASVAPLLEFPDAANTGSSKGVSAQCLFDLLQSLEGETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKMKRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSRSDQGHKGTTTANHTMSSGVNTRYPEQGAKLHFIRENLHLLEEGQGLPREELDERISREEFRRPRESLLNICTEFYKHCGPRLKILQNLAGEPRVTALELLDVKSHMRLAEIAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWSAEAVRPALILILKRLDRMFNKIHKMPTLRRQVEWEPASSLIEGVCLTLQRQPIISFLPHLRSLINVCVNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVISPFTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVQLLLQTVINVLLPPRIISTSRSKNFMLESSPAHCSTPGDAGKDLRKEGLAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQCKLLAQPAENHEELSARQHISDQLERRFIPRPLCKSSLIAEFNSELKILKEAVHSGSAYQGKTSISTVGTSTSAYRLSLATMSRSNTGTGTVWEQDSEPSQQASQDTLSRTDEEDEENDSVSMPSVVSEQEACLLSTIGRRRFSSHVSSMSAPQAEVGMLPSQSEPNVLDDSQGLAAEGSLSRVASIQSEPGQQNVLLQQPLGRKRGLRQLRRPLLSRQKTQTEPRNRHGARLSTTRRSIQPKTKPSVDQKRSVTFIEAQPEPTAAPTDIFPATGQPQSCSPGRARKPEGTEKPVLTSSPAIIIADLHSLSPKQSEPLLAEEGEKKEDEEIQGATAHCPLSTQLSDPDDFTGLETSSLLQHGDTVLHISEENGTENPLLSSQFTFTPPELGDTDSALDESHV
What is the function of this protein?
Auxiliary subunit of the NALCN sodium channel complex (PubMed:32620897, PubMed:19092807, PubMed:21040849).  The NALCN sodium channel complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:32620897).  This complex is activated by neuropeptides substance P, neurotensin.  In addition, the channel is inhibited by extracellular Ca(2+) through the Ca(2+)-sensing receptor.  UNC80 is essential for NALCN sensitivity to extracellular calcium.
What are the official names of this protein?
Protein unc-80 homolog, mUNC-80.
What is the protein family that this protein belongs to?
Belongs to the unc-80 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=In neurons, located in soma and dendrites.