PharMolix/UniProtQA huggingface dataset:
Protein: ZN503_HUMAN
Sequence: MSTAPSLSALRSSKHSGGGGGGGGGGGADPAWTSALSGNSSGPGPGSSPAGSTKPFVHAVPPSDPLRQANRLPIKVLKMLTARTGHILHPEYLQPLPSTPVSPIELDAKKSPLALLAQTCSQIGKPDPSPSSKLSSVASNGGGAGGAGGGAAGDKDTKSGPLKLSDIGVEDKSSFKPYSKPGSDKKEPGGGGGGGGGGGGGGGGVSSEKSGFRVPSATCQPFTPRTGSPSSSASACSPGGMLSSAGGAPEGKDDKKDTDVGGGGKGTGGASAEGGPTGLAHGRISCGGGINVDVNQHPDGGPGGKALGSDCGGSSGSSSGSGPSAPTSSSVLGSGLVAPVSPYKPGQTVFPLPPAGMTYPGSLAGAYAGYPPQFLPHGVALDPTKPGSLVGAQLAAAAAGSLGCSKPAGSSPLAGASPPSVMTASLCRDPYCLSYHCASHLAGAAAASASCAHDPAAAAAALKSGYPLVYPTHPLHGVHSSLTAAAAAGATPPSLAGHPLYPYGFMLPNDPLPHICNWVSANGPCDKRFATSEELLSHLRTHTAFPGTDKLLSGYPSSSSLASAAAAAMACHMHIPTSGAPGSPGTLALRSPHHALGLSSRYHPYSKSPLPTPGAPVPVPAATGPYYSPYALYGQRLTTASALGYQ
What is the function of this protein?
May function as a transcriptional repressor.
What are the official names of this protein?
Zinc finger protein 503.
What is the protein family that this protein belongs to?
Belongs to the Elbow/Noc family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MINE_BURMA
Sequence: MSILSFLLGEKKKSAAVAKERLQLIIAHERVGGRPPADYLPALQKELVAVISKYVKISNDDIRVSLERQDDLEVLEVKIEIPQA
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: OBG_PROMP
Sequence: MQFIDQANIILKAGKGGNGIVSFRREKFVPAGGPSGGNGGKGGSIIIIADNNLQTLLDFKFNREIFAKDGFKGGPNKRSGASGENTILKVPCGTEIRDFNTGIILGDLTEDKQSLTIAHGGRGGHGNAYYLSNQNRAPESFTEGKEGEIWEVQLELKLLAEVGIIGLPNAGKSTLISVLSSARPKIANYPFTTLIPNLGVVRKADGNGCLFADIPGLISGAAEGVGLGHDFLRHIQRTKILIHLIDSIAENPIRDFEIIEKELKRYGSGLLNKERIVVLNKMELVDENYLQTITKKLENLSKKKVLVISSSLRKGLSPLLSEVWKRI
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_RHIEC
Sequence: MRCPYCGSEDTQVKDSRPAEDNTSIRRRRICPDCGGRFTTFERVQLRELMVIKKTGRKVPFDRDKLVRSFEVALRKRPVERDRIERAVSGIVRRLESSGETEISSEQIGLQVLEAMKSLDDVGFVRYASVYRDFSLAEDFEKVISEINAKIARDPLDR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RL331_META1
Sequence: MKNTKKITLACQVCLAKNYSTNKSVTNRLEIKKFCKHCNMQTLHKEEK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: Y2147_ARCFU
Sequence: MEIIQNVFNRAENGDRIMISFPDMLSFFTVTKWLNEQFGNPLWILWTDAAVERLNHLGKKLGYPVSGNAVTIGAIKECLFLDVVARYDFYDDVSSLLKSLPVGNVLLISFGVNFLEIFGQGLSKAIEFIIEHENGILCTCTVGEAPDILLPFHDTFIEIKSGEESYLTYKSYVAKLRFSVDGGTIEMSDSFLVSE
What are the official names of this protein?
Uncharacterized protein AF_2147.
Protein: LEPA_STRA3
Sequence: MNIEDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRAEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGEVDAPLQALIFDSVYDAYRGVILQVRIVNGMVKPGDKIQMMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVADTRVGDTITLANNPAIEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSEFPDPTRVDSIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYEISEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDDKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LPXK_PECCP
Sequence: MIERIWSGRSRLYWLLLPLSWLYGFITFLIRQSYRLGWRKSWRAPVPVVVVGNLTAGGNGKTPVVIWLVEHLQRRGYRVGVVSRGYGGKAERYPLLLDDTVTTAQAGDEPVLIFQRTGAPVAVAPRRRDAVSALLAQHTLDVVITDDGLQHYALERDIELVVIDGMRRFGNGWWLPAGPMRERESRLTSVDAVIVNGGTPRTNEIGMTLTAGMAVNLLSGESRPLSQLHDVVAMAGIGHPPRFFATLREAGVSIAREIAFADHQSYQPEQLESLTQDATQPLLMTEKDAVKCKTFAQRNWWYLPVDAMLAEPRATQLLDKLESVIKRHTSNRT
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: EFP_STAAR
Sequence: MISVNDFKTGLTISVDNAIWKVIDFQHVKPGKGSAFVRSKLRNLRTGAIQEKTFRAGEKVEPAMIENRRMQYLYADGDNHVFMDNESFEQTELSSDYLKEELNYLKEGMEVQIQTYEGETIGVELPKTVELTVTETEPGIKGDTATGATKSATVETGYTLNVPLFVNEGDVLIINTGDGSYISRG
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBP2_METMA
Sequence: MSESSIKIENVVASTKLAEEFDLTVIESQFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSGKVVCTGAKNVADVHTVIGNMAKKLNSIGIKTMENPQITVQNIVASADLHTILNLNAIAIGLGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVTGGKTPEDCESGVEVVRQQLDNMGLL
What is the function of this protein?
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
What are the official names of this protein?
TATA-box-binding protein 2, Box A-binding protein 2, BAP 2, TATA sequence-binding protein 2, TBP 2, TATA-box factor 2.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
Protein: EX7S_LEUCK
Sequence: MSETKTFEDKLQQLEGIVSELEKGDRPLETALADFQTGVGLVKELQGTLKHAEETLAKVMSDDDKLTDLELTND
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BHLA_BACSU
Sequence: MEMDITQYLSTQGPFAVLFCWLLFYVMKTSKERESKLYNQIDSQNEVLGKFSEKYDVVIEKLDKIEQNFK
What is the function of this protein?
May be involved in the secretion of the autolysin BlyA.
What are the official names of this protein?
SPbeta prophage-derived protein BhlA.
Protein: U496M_ARATH
Sequence: MRNCLSFNPASPEASLGDDPLPHPSLESGVASTSRNDASISSPTFNLSRELAHAFQTPSYHDVRSRVHVVVDLTQIHHRLIQPDIELLLSQVLQPNKECVQEAIRHVKQTTLTNLVSTYFQHSEDATRLCLNLYQNVHSARHHLYTPLLDLFNIFPGDSLPAIDESLCDLAFDVFLKLDTFENPFSSPESYSFRDTQLCFSQLKHNLDRRLRKSRSRVRLIHHATAGSSLCLVAAVVAVAASAVVIASHALPILLVVAGPLCSPYLPHSFKRKELTNICQLNAASKGTFVLNKDLDTIDRLVSRLHTGIEYDKFLIRLGLERGRDVHSIQEILKLLRKSHLPLTHQLKDLEDHICLWFTNVNKARSLLLTEIHLPRPSHVIL
What are the official names of this protein?
UPF0496 protein At3g19330.
What is the protein family that this protein belongs to?
Belongs to the UPF0496 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KAE1B_METMP
Sequence: MDNSKDDLICIGFEGTAEKSGVGIITSKGEVLFNKTIIYTPPVQGIHPREAADHHAETFVKLLKEALNEVPLEKIDLVSFSLGPGLGPSLRVTATTARALSLSINKPIIGVNHCIGHVEIGKLTTDAVDPLTLYVSGGNTQVLAYTGKKYRVIGETLDIAIGNCLDQFARHCNLPHPGGVYVEKFAKDGNKFIKLPYTVKGMDLSLSGLLTSAMKKYDSKERIEDVCYSLQETSFSMLTEITERALAHTNKAEVMLVGGVAANNRLKEMLKVMCEEQNVDFYVPEKQFCGDNGAMIAWLGILQYLNGKRMDLKDTKPISNYRSDMVEVNWIHDESKNLNDGNIKSRKIPKHLIGKGAEADISKGRYLEFESITKERVKKGYRILKLDELIRTRRTVKEARFLAAVKECGIHAPSIYDIDKENKKIIMGYIHGKIAKDEIEEGNIEFCKSLGETIGKMHGSGIVHNDLTTSNFIISKNPYIIDFGLGKYSDLIEDKAIDLIVLKKSIMSIHYDKFDLVWNKIIDGYKTYELAESVLECIKEVEKRARYL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  The Kae1 domain likely plays a direct catalytic role in this reaction.  The Bud32 domain probably displays kinase activity that regulates Kae1 function.
What are the official names of this protein?
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_APOCA
Sequence: DILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIDAVPGEEDQFIAYVAYPLDLFEEGSVTNMLTSIVGNVFGFKALRALRLEDLRIPPAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIFKSQAETGEIKGHYLNATAGTCEEMYKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHXAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLXVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAVEGNEIIREASKWSPELAAACEVWKEIRFNFKAVDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RUTC_CAUVN
Sequence: MPKTVITPPGTQTPIAPFSPGTLADGIVYVSGTLAFDKDNNVAFPGDAEAQTRQVLETIKSVIETAGGTMEDVTMNHIFLTDWVHYAPMNKVYAEYFPGDKPARYCIQCGLVKPGFVVEIASVAHIGKT
What is the function of this protein?
Involved in pyrimidine catabolism.  Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously.  RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.
What are the official names of this protein?
3-aminoacrylate deaminase RutC, 3-AA deaminase.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: GATA_WOLTR
Sequence: MNELRKLSIAQMHNGLKQRSFSAVELIEVHINAVENEKLNAFITKTPEIAIKAAKTADERFSQQKDSTISPLMGIPVGVKDLFCTKGVKTTACSKMLENFIPTYESTVSDLLLKSGAAMLGKLNMDEFAMGSANINSYFGPVENVWVRKSDGEKVVPGGSSGGSAASVAGFLCAGALGSDTGGSVRQPAAYCGVVGAKPTYGRCSRFGMIAFASSLDQAGVITRSVSDSALMLETICGYDNKDSTSSERPVPRFSNFINGDIKGRRIGIPKEYRMDGISEEIIYHWEKVSSDLKENGAEVVDITLPHTKYAIPVYYLICSAEASSNLARYDGVRYGLRVNADILEEMYSLTRAEGFGKEVKRRILIGAYALSSGHYNEYYEKAQCIRALIRNDFIKAFEKIDYILVPSAPTEAFGLNEKPDPLIMCINDVFTVPASLAGLPAISVPVGLSNEGLPLALQVIGNYYDEAGMLNVASVIEQNCSRIIKLNS
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: YEEX_SALTI
Sequence: METTKPSFQDVLEFVRLFRRKNKLQREIQDIEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIIASMKSDYEDRVDDYIIKNAEISKERRDISKKLKAMGEMKHADVKAE
What are the official names of this protein?
UPF0265 protein YeeX.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: PAQR3_MOUSE
Sequence: MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPVSLKDNPYITDGYRAYLPSRLCIKSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASREDFVICSICLFCFQVCMLCSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGVFYAFYCNNYWRQVYLITVLAMILAVFFAQIHPSYLTQQWQRLRPIIFCSVSGYGVIPTLHWVWLNGGVSAPIVQDFAPRVIVMYVIALLAFLFYISKVPERYFPGQLNYLGSSHQIWHVLAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL
What is the function of this protein?
Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
What are the official names of this protein?
Progestin and adipoQ receptor family member 3, Progestin and adipoQ receptor family member III, Raf kinase trapping to Golgi, RKTG.
What is the protein family that this protein belongs to?
Belongs to the ADIPOR family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: COX1_ACACA
Sequence: MINRLLNNLTSFFTDNRWLFSTNHKDIGTLYLIFGGFSGIIGTIFSMIIRLELAAPGSQILSGNSQLYNVIITAHAFVMIFFFVMPVMIGGFGNWFVPLMIGAPDMAFPRLNNISFWLLPPSLFLLLCSSLVEFGAGTGWTVYPPLSSIVAHSGGSVDLAIFSLHLAGISSLLGAINFITTIFNMRVPGLSMHKLPLFVWSVLITAFLLLFSLPVLAGAITMLLTDRNFNTSFFDPSGGGDPILYQHLFWFFGHPEVYILILPAFGIVSQIIGTFSNKSIFGYIGMVYAMLSIAVLGFIVWAHHMYTVGLDVDTRAYFTAATMMIAVPTGIKIFSWIATLWGGQIVRKTPLLFVIGFLILFTLGGLTGIVLSNAGLDIMLHDTYYVVAHFHYVLSMGAVFAFFAGFYYWFWKISGYTYNEMYGNVHFWLMFIGVNLTFFPMHFVGLAGMPRRIPDYPDNYYYWNILSSFGSIISSVSVIVFFYLIYLAFNNNNTPKLIKLVHSIFAPYINTLSKNLLTFASIKSTSDSSFFKFSKFFIFFMVSLSVLFIFYDSLLCLNDHTNSWKIGFQDPTTPIAYGIIKLHDHILFFLAVILFVVGYLLLSTYKKFYYGSLNNDLPESKRISLFDTLINTYKENLSFNVTNRTYNINHGTTIEIIWTILPAFILLFIAVPSFALLYAMDEIIDPVLTVKVIGHQWYWSYEYSDYSVVYSNRMLDYDSIDRFAAMEMMYKGMGYLKDRSLLSYLYIPMVIPETTIKFDSYMIHEAELNLGDLRLLKTDMPLFLPKNTHIRLLITSSDVLHSWAVPSFGVKVDAVPGRLNQTSLYLKNTGTFYGQCSELCGVNHAFMPIEVYVVNPVYFYNYVYIYFKNFNLI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1+2, Cytochrome c oxidase polypeptide I+II.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MNHE2_STAAE
Sequence: MNQIVLNIIIAFLWVLFQDEDHFKFSTFFSGYLIGLIVIYILHRFFSDDFYVRKIWVAIKFLGVYLYQLITSSISTINYILFKTKDMNPGLLSYETRLTSDWSITFLTILIIITPGSTVIRISQDSKKFFIHSIDVSEKEKDSLLRSIKHYEDLILEVSR
What are the official names of this protein?
Putative antiporter subunit mnhE2, Mrp complex subunit E2, Putative NADH-ubiquinone oxidoreductase subunit mnhE2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VIE2_HCMVT
Sequence: MESSAKRKMDPDNPDEGPSSKVPRPETPVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFERVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSVSSAPLNKPTPTSVAVTNTPLPGASATPELSPRKKPRKTTRPFKVIIKPPVPPAPIMLPLIKQEDIKPEPDFTIQYRNKIIDTAGCIVISDSEEEQGEEVETRGATASSPSTGSGTPRVTSPTHPLSQMNHPPLPDPLGRPDEDSSSSSSSCSSASDSESESEEMKCSSGGGASVTSSHHGRGGFGGAASSSLLSCGHQSSGGASTGPRKKKSKRISELDNEKVRNIMKDKNTPFCTPNVQTRRGRVKIDEVSRMFRNTNRSLEYKNLPFTIPSMHQVLDEAIKACKTMQVNNKGIQIIYTRNHEVKSEVDAVRCRLGTMCNLALSTPFLMEHTMPVTHPPEVAQRTADACNEGVKAAWSLKELHTHQLCPRSSDYRNMIIHAATPVDLLGALNLCLPLMQKFPKQVMVRIFSTNQGGFMLPIYETAAKAYAVGQFEQPTETPPEDLDTLSLAIEAAIQDLRNKSQ
What is the function of this protein?
Stimulates viral early and late gene expression and thus play a crucial role in the regulation of productive infection.  In addition, activates quiescent cells to reenter the cell cycle and up-regulates several E2F-responsive genes, which are responsible for pushing the cell into S phase.  In S-phase, inhibits cellular DNA synthesis and blocks further cell cycle progression.
What are the official names of this protein?
Viral transcription factor IE2, IE2, Protein UL122.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 IE2 protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=Colocalizes with host PML-associated nuclear bodies.
Protein: YKE4_YEAST
Sequence: MKASHICSYLLSIAPLVVSHGVHHNRDHGHEANHESKQSFLILKQESIFYSLVCFLQNHLFVLGPRYNAIVAILIIQLMPCLFVLFVPGLRKNDRASLTLSLLVSFSLGTLLGDILLHVIPESLSGVTDVTMVGGAIFLGFISFLTLDKTMRILSGTSNDDGSIHSHSHSHTPQQTAEKKAGFNMSAYLNVISGIAHHITDGIALATSFYSSTQVGIMTSIAVTFHEIPHELGDFAILLSSGFTFPQAIRAQAVTAFGAVVGTSIGCWMNEIGNNSHKATSSSANASELMLPFTAGGLIYIATTSVVPQILHSSAPDSKLREFKKWALQLVFIFVGFAVMALMDEH
What is the function of this protein?
Zinc transporter whose role depends on the zinc status of the cells.  It helps to balance zinc levels between the cytosol and the secretory pathway.  It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium.  In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol.  Under low cytosolic zinc conditions, it removes zinc from the secretory pathway and acts as zinc importer that helps to alleviate ER stress.
What are the official names of this protein?
Zinc transporter YKE4.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: Y4343_METS4
Sequence: MRITWFGHSAFRLDFGESHVLIDPFFTGNPAFEGGDAARARAVEGATHILITHGHGDHVGDTLAVAAETGAKVVTNYDLCMWLGSKGLTNFDPMNTGGTTDQGGFKVTLVRADHSAGMSEAGVTVPLGLPNGVVVRAPGEPTVYHMGDTDIFGDMALIQEIYRPDVLIVPIGDRFTMGAETAALAVRKFFAPRAVIPCHYGSFPIIAASADAFVAALDGSGVQVVVPHKGTAVTIA
What are the official names of this protein?
UPF0173 metal-dependent hydrolase M446_4343.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: PIF1_YEAST
Sequence: MPKWIRSTLNHIIPRRPFICSFNSFLLLKNVSHAKLSFSMSSRGFRSNNFIQAQLKHPSILSKEDLDLLSDSDDWEEPDCIQLETEKQEKKIITDIHKEDPVDKKPMRDKNVMNFINKDSPLSWNDMFKPSIIQPPQLISENSFDQSSQKKSRSTGFKNPLRPALKKESSFDELQNNSISQERSLEMINENEKKKMQFGEKIAVLTQRPSFTELQNDQDDSNLNPHNGVKVKIPICLSKEQESIIKLAENGHNIFYTGSAGTGKSILLREMIKVLKGIYGRENVAVTASTGLAACNIGGITIHSFAGIGLGKGDADKLYKKVRRSRKHLRRWENIGALVVDEISMLDAELLDKLDFIARKIRKNHQPFGGIQLIFCGDFFQLPPVSKDPNRPTKFAFESKAWKEGVKMTIMLQKVFRQRGDVKFIDMLNRMRLGNIDDETEREFKKLSRPLPDDEIIPAELYSTRMEVERANNSRLSKLPGQVHIFNAIDGGALEDEELKERLLQNFLAPKELHLKVGAQVMMVKNLDATLVNGSLGKVIEFMDPETYFCYEALTNDPSMPPEKLETWAENPSKLKAAMEREQSDGEESAVASRKSSVKEGFAKSDIGEPVSPLDSSVFDFMKRVKTDDEVVLENIKRKEQLMQTIHQNSAGKRRLPLVRFKASDMSTRMVLVEPEDWAIEDENEKPLVSRVQLPLMLAWSLSIHKSQGQTLPKVKVDLRRVFEKGQAYVALSRAVSREGLQVLNFDRTRIKAHQKVIDFYLTLSSAESAYKQLEADEQVKKRKLDYAPGPKYKAKSKSKSNSPAPISATTQSNNGIAAMLQRHSRKRFQLKKESNSNQVHSLVSDEPRGQDTEDHILE
What is the function of this protein?
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.  Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids.  Appears to move along DNA in single nucleotide or base pair steps, powered by hydrolysis of 1 molecule of ATP.  Processes at an unwinding rate of about 75 bp/s.  Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs.  Involved in the maintenance of telomeric DNA.  Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase.  Reduces the processivity of telomerase by displacing active telomerase from DNA ends.  Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction.  Involved in the maintenance of ribosomal (rDNA).  Required for efficient fork arrest at the replication fork barrier within rDNA.  Involved in the maintenance of mitochondrial (mtDNA).  Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks.  May inhibit replication progression to allow time for repair.  May have a general role in chromosomal replication by affecting Okazaki fragment maturation.  May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.
What are the official names of this protein?
ATP-dependent DNA helicase PIF1, DNA repair and recombination helicase PIF1, Petite integration frequency protein 1, Telomere stability protein 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. PIF1 subfamily.
What are the subcellular locations of this protein?
[Isoform Nuclear]: Nucleus, nucleolus. Note=Mainly concentrated in the nucleolus, and occasionally redistributes to single nuclear foci outside the nucleolus, probably sites of DNA repair. SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Bound to the mitochondrial inner membrane either directly or indirectly via a protein complex.
Protein: ATPL_ANOFW
Sequence: MGVLAAAIAIGLAALGAGIGNGLIVSRTVEGIARQPEARGMLQTTMFIGVALVEAIPIIAVVIAFMVQGR
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.