PharMolix/UniProtQA huggingface dataset:
Protein: CH60_PARD8
Sequence: MAKEIKYDMDARDLLKKGVDELANAVKVTLGPKGRNVIIEKKFGAPHITKDGVTVAKEVELTCPFENMGAQLVKEVASKTNDNAGDGTTTATVLAQSIIGVGLKNVTAGANPMDLKRGIDKAVAKVVESIANQAEAVGDKFEKIEHVAKISANGDEAIGKLIAEAMQRVKTEGVITVEEAKGTETTVDVVEGMQFDRGYISPYFVTDTEKMECQMENPYILIYDKKISVLKDLLPILEPTVQSGRPLLIIAEDIDSEALATLVVNRLRGSLKICAVKAPGFGDRRKAMLEDIAVLTGGTVISEEKGLKLEGATMDMLGTAEKITVDKDTTTIVNGAGDKEAIQARIGQIKIQMENTTSDYDKEKLQERLAKMAGGVAVLYVGAPSEVEMKEKKDRVDDALHATRAAIEEGTVPGGGVAYIRAIDALEGMKGDNEDETTGIEIVKRAIEEPLRQIVANAGKEGAVIVQKVKEGKGDFGYNARKDCFENLCEAGVIDPAKVTRVALENAASIAGMFLTTECVIAEKKEETPAMPPMNPGMGGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_GLOVI
Sequence: MPNLRGIRDRIKSVKNTQKITKAMRLVAAARVRRAQEQVLAGRPFADRLVGLLFRLRSRLRFEDVQSPLMERRDVQKVLVLVIAGDRGLCGAYNSNIIRRTVQYLRELQQQGKQFALYLVGNKAISFFRRSNFPIAKTLTNVDPNTPLEGANQLITDDILAPFLSGEYDQVELVYTRFVSLISSRPTVQTLLPLDPDALGQEDETFKLITKGGGFEVLREKQQVRTEPEFAADTIFEQDPTQLLDALLPLYLTSEVLHALQESSASELAARMTAMSAASDNAKKLLSTLTIVYNKARQASITQEILEVVSGANA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GPMA_CORDI
Sequence: MTTGKLILLRHGQSEWNASNQFTGWVDVNLTEKGEAEAKRGGELLKAQGVLPSVVYTSLLRRAIRTANIALNAADRHWIPVVRDWRLNERHYGALQGLNKAETKEKYGDEQFMAWRRSYGTPPPELEDSSEFSQANDPRYANLDVVPRTECLKDVVERFVPYFKEEILPRVKNGETVLIAAHGNSLRALVKHLDNISDADIAELNIPTGIPLVYELDEAGTVLNPGGTYLDPEAAAAGAAAVAAQGAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: IQIP1_HUMAN
Sequence: MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK
What is the function of this protein?
May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943).  May also play a role in axon outgrowth and guidance (By similarity).
What are the official names of this protein?
IQCJ-SCHIP1 readthrough transcript protein.
What are the subcellular locations of this protein?
Cell projection, axon. Cytoplasm. Note=Localizes to the axon initial segments (AIS) and nodes of Ranvier of neurons and is absent from dendrites.
Protein: IF2_MOOTA
Sequence: MAKTRVYELAKELKVTNKDLIDTMARLGIYTRSHMSVLENGEVIKVRNHYRQQWRAAKLARMHREQATLKGEGPVPTRGVPDAPRAEEVPSRQVPAPETGAPAQATGATRQPATGSARPANTDETRVQEHKPATAARQAGDAPAAEGTAAAGQPLDGKELRQAVANGQGTEEPRQQPAATGQRAQGGEAGRGQQSRQKKKRRGEGRSRQDENKGSAREDQANRFATRDKEAAPSAGQQSPAEKGQRRPAHSKPLRIPKPPEAVTKDLPEKRRDRSNARPGAKPAESGRSRKREMENQLEERLMRRDKNKGKAQKHKETPKVVFKITLTGSITVQELAKRIGKTAAEVIKYLMGQGIMATINQELDLETAALVAQDLGAIVEIKAEKPITELEDLVDPPETLRERPPVVTVMGHVDHGKTSLLDAIRRTNVTASEAGGITQHIGAYQVRLKNRKITFLDTPGHAAFTAMRARGAQATDIAILVVAADDGVMPQTIEAINHAKAAGVPIVVAINKIDRPEANPERVKQQLTEYGLVPEEWGGDTIMVPVSAVTKEGINDLLEMVLLTADVAELKANPDRPARGIVIEAKLDRGRGPVATMLVQKGTLKIGDNLVAGSVYGRVRAMIDDRGERVNSAPPSTPVEVLGLSELPEAGDIFQVVEDEKLARQIASSRQEEKRQEELKAASKTTLDDLFKQMEAGEVKELNLVIKGDVQGSVEALRGALEQLSTSEVKVNLLHGGVGAITETDVMLAAASKAIIIGFNVRPEANVRKAAEEAGVEIRLYRVIYEVIDDVKAAMSGLLEPEEREVILGRAEVRATFKVPKAGTVAGCFVTEGKIQNRALARVIRDGVVVFEGRIESLKRFKDDVREVAQGYECGVGLEKFNDIKEGDVIEAYTIEEIQREL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAM_MYCA1
Sequence: MWDPDVYLAFADHRARPFYDLLSRVGAERARRVVDLGCGPGHLTKYLGRRWPDAVIEAMDSSPEMVAAAKERGIDAVTGDLRNWKPKPDTDVVVSNAALHWVPEHSDLLLRWAGQLAPGSWIGVQMPGNFESPSYAAVRALARREPYAKLLRDIPFRVGAVVQPPTHYANMLLDAGCKVDVWETTYLHQLTGEHPVLEWITGTALVPVRERLDDDAWEQFREELIPLLRDAYPPRADGTTIFPFRRVFIVAEVGSGRPAA
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARL8B_MACFA
Sequence: MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRYRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQYSKSRRS
What is the function of this protein?
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states.  In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation.  Along with its effectors, orchestrates lysosomal transport and fusion.  Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes.  Required for lysosomal and cytolytic granule exocytosis.  Critical factor involved in NK cell-mediated cytotoxicity.  Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity).  In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity).  Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense.  Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes.  Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing.  Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity).  Involved in the process of MHC II presentation.  Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity).  May play a role in chromosome segregation (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 8B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Cell projection, axon. Synapse. Cytolytic granule membrane. Note=GTP- bound form resides on lysosomal membranes, whereas GDP-bound form is likely associated with microtubular structures. Localizes with microtubules at the spindle mid-zone during mitosis (By similarity). In dendritic cells, localizes to MHC II+ compartments (By similarity).
Protein: UPP_FINM2
Sequence: MSKVTVFDHPLIKHKLTILRDKNTGSNQFRQLVSEIATLMCYEVTRDFKLEDCEVETPIGKTTGQTLSGKKLGVVPILRAGLGMVEGFLSVLPAAKVGHIGLYRDPKTLKPVEYYCKLPKDVEERDIIVVDPMLATGGSAEAAITFLKEHGCKNIKLVNIIAAPEGIKMVQEKHPDVDIYVAGLDEKLNDHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: GUF1_CANAL
Sequence: MLLRPNSGNTLKYGCLLTKRWLTTSKLLYSVEDMKIKIGQEQYRKALEERIDKIPIENYRNFSIVAHVDHGKSTLSDRLLEMTGVIKPGSKSQVLDKLDVERERGITVKAQTVSMFYNDGKQDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGVQAQTVANFYLAYSMGLKLIPIINKIDLDSANIPGAREQIETTFELDPNECIPVSAKTGLNVEQIIPSVIKNIPSPVCDVNKPLRALLVDSWHDPYVGVVMLVHIVDGRMKKGMKILSAHTNRTYDVKEVGIMYPDRTPTSFIKAGQVAYIIPGMKNPREALVGDTFYQMGKHEGLEPLPGFEEPKPMVFVGAFPADGKEFNAMDDQMQNLVLNDRSVTLEQETSNALGLGWRLGFLGSLHASVFKERLEKEYGAKIILTAPTVPYKIIYKNGEEKIVTNPDDFPDNQKHHDVESYMEPYVEAIMTVPNEYVGNVMTLCLNNRGEQKEIEYLTTGQVLLKYEIPTSQLVEDFFGKLKGCTKGYASLDYEEAGYRKSDIVKMQLCVNGEPQDALTTVIHRSQAQARGKEYVTRFKKFLSYQLFEVAIQAKINNKVVARETIKAKRKDVTQRLHAADISRYKKLLERQKEGKKQMKLSGRVTIKNDAYQAFLRRED
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: CSN8_DICDI
Sequence: MAFTEIANLISSKNFKAILDYCQRQEIESKNIDLIKSYYGVYLLSYLINNDLINAKHLWKRIPNDFKQSNQQLKNIYTIIKSISQTNPTITYTSLSINIGDDYTPFITTLKENFQQRTFELISNAYSSITVNDCSSYLGISPEDTIKFTTSKCWEHDKASNTLKPVPIQKQSSELPTGNQQIRSLTSYVLFLEKST
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
What are the official names of this protein?
COP9 signalosome complex subunit 8, Signalosome subunit 8.
What is the protein family that this protein belongs to?
Belongs to the CSN8 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MNMG_PARDP
Sequence: MKQFDVIVIGGGHAGVEAAMAAARMGVKTALVTLHRDDIGTMSCNPAIGGLGKGHLVREIDALDGVMGKLADTAGIQFRLLNRRKGPAVQGPRAQADRKLYRSAAAKIVAGQDGLSLILGEAAELLHERGQVTGLRLADDSELQARQIILTTGTFLNGLIHIGEISRQAGRWGGSTSVTLAASLRPLNLPLGRLKTGTPPRILRQSIDWESLHQQPGDEEPVMFSYLNTVPEAPQVSCAITHTNPDTHRIIRENLARSAMYGGRIDGVGPRYCPSIEDKVVRFADKESHQIFLEPEGLDSDLVYPNGISTSLPEDIQLAYVRSIRGLERAQIAQPGYAVEYDYVDPRALAASLEVKNLSGLFLAGQINGTTGYEEAAAQGLVAGLNAALKAQGREALHFSRSQSYIGVMIDDLTTRGVSEPYRMFTSRAEFRLSLRADNADQRLTPFGIDIGCVGQERRAAFSEKMRRYTAARDRAESVSFTPTELSRSGIEVRHDGARRSLFALLAQQEIPQDQVLALDDQLVLQDPAIIRQLATDALYHQYTDRQGKDAELLRKEEAVAIPAEFDYDALSGLSNELKFKLNQHRPATLAAAANIEGMTPAALTLILAVIRAGNRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_BACMK
Sequence: MNKRDYYEVLGLSQGASKDEIKKAYRRLAKKYHPDVSKEENAIEKFKEVQEAYEVLSDDQKRAQYDQFGHAGPNQGFGGGGDFGGGFGFEDIFSSFFGGGGGRRRDPNAPRQGADLQYQVTLEFEEAIFGKELNVEIPVEDPCDTCKGSGAKPGTSKETCKHCSGSGQVSVEQNTPFGRIVNRQACGHCSGTGQMIKEKCTTCHGSGKVRKRKKINVKIPAGIDNGQQIRVSGKGEAGVNGGPAGDLYVVVHVRNHEFFEREGDHIICEMPITFAQMALGAEVEVPTVHGKVKLKIPAGTQTGTEFRLKGKGAPNVRGYGQGDQYVVVRVVVPTKLTSHQKDLLREFAGQEEQDDSLFRKLKRAFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_BORRA
Sequence: MGRECEITGKRTMFGNNVPRKGLAKKKGGAGQHIGVKTKRTFKVNLINKKFFIPELGKNVSIKISASTLRSISKVGLNVFLKKNNKKIDDFI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: IL12A_CAPHI
Sequence: MCPLRSLLLISTLVLLHHLPHLSLGRSLPITTAGPGRSCLDYSQNLLRAVSNTLQKARQTLEFYSCTSEEIDHEDITKDKTSTVEACLPLELATNESCLASRETSLITNGHCLASGKTSFMTTLCLRSIYKDLKMYHMEFQAINAKLLMDPKRQVSLDQNMLAAIAELMQALNFDSETVPQKPSLEELDFYKTKVKLCILLHAFRIRAVTIDRMMSYLSSS
What is the function of this protein?
Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine.  IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity.  Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits.  Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2.  In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity).  As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity).  Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers.  Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
What are the official names of this protein?
Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYFA_NEIG1
Sequence: MENVNRIVAEGIAAVEAAQDFNALEQIKARYLGKTGELTGLLKTLFTGQMSPEERKTIGAHINECKNRFQTAFNAKRDALNEAKLQARLAAEALDITLPGRAQEGGFTSLHPVTLTLQRVVELFHGMGFEVADGPEIEDDFHNFQALNIPANHPARAMQDTFYVENGFTDVLRTHTSPIQIRYMLDKKEPPIRIIAPGRVYRVDSDATHSPMFHQAEGLWVEEGVTFAFTDLKAVFTDFIRRFFERDDLQVRFRPSFFPFTEPSAEIDIMGENGKWLEVGGCGMVHPNVFTLKNVNIDPEKYTGFAFGIGLDRFAMLRYNVNDLRLFFDNDLNFLKQFE
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_BACC0
Sequence: MRIAVIGAMEEEVRILRDKLEQAETETVAGCEFTKGQLAGHEVILLKSGIGKVNAAMSTTILLERYKPEKVINTGSAGGFHHSLNVGDVVISTEVRHHDVDVTAFNYEYGQVPGMPPGFKADEALVALAEKCMQAEENIQVVKGMIATGDSFMSDPNRVAAIRDKFENLYAVEMEAAAVAQVCHQYEVPFVIIRALSDIAGKESNVSFDQFLDQAALHSTNFIVKVLEELK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: MUTS_ECOL6
Sequence: MSTIENFDAHTPMMQQYLKLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMERQQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAELQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLENVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESISPNAAATQVDGTQMSLLSVPEETSPAVEALENLDPDSLTPRQALEWIYRLKSLV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RSSA_ASPTN
Sequence: MAPSQLPPMFNPTPQDIEMLLAAQCHLGSKNLQVHMEPYLWKTRPDGVNVINIGKTWEKILLAARIIAAIDNPADICVISARPYGQRAVLKFASHTGATAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTDFVDVAIPTNNKGRHSIGLVWWLLAREVLRLRGTLASREAEWDVVVDLYFYRDPEAEENKEIAEEAKVPGADEIGAGAVESGFAGENWETQAPGAGVPGTAFAAASAAGATSWEADGADWAASSAAAPAESWAAEAQGAEGAKW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB5A_MOUSE
Sequence: MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPAQPARSQCCSN
What is the function of this protein?
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states.  In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  RAB5A is required for the fusion of plasma membranes and early endosomes.  Contributes to the regulation of filopodia extension.  Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (By similarity).  Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (PubMed:18425118).
What are the official names of this protein?
Ras-related protein Rab-5A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Cytoplasmic vesicle. Cell projection, ruffle. Membrane. Cytoplasm, cytosol. Cytoplasmic vesicle, phagosome membrane. Endosome membrane. Note=Enriched in stage I melanosomes. Alternates between membrane-bound and cytosolic forms.
Protein: RL18_MARN8
Sequence: MSANNERLRRARKVRMKIRELGTDRLCVHRTPRHMYAQVTTADGSKVLATASTLDKELRQGATGNVDAAKKVGQLIAERAKAAGIEKVAFDRSGYRYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: NUOB_BORPD
Sequence: MAIDGILKQGFITTSADKFLNWAKTGSMWPMTFGLACCAVEMMHAGAARYDLDQFGIIFRPSPRQSDLMIVAGTLCNKMAPALRKVYDQMPEPRWVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALVYGLLQMQNKIRLTNTIAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.