PharMolix/UniProtQA huggingface dataset:
Protein: RRP3_ASPOR
Sequence: MPAIKKRKIAREAPQQEDHSDSEAHSSASEDAAPNTTEQEQEPSEAPKQAPKSFKELGLIEQLCEACDSMGYKAPTAIQAEAIPLALQGRDLIGLAETGSGKTAAFALPILQALMDKPSSFFGLVLAPTRELAYQISQAFEGLGSTISVRSTVLVGGMDMVSQSIALGKKPHIIVATPGRLLDHLENTKGFSLRNLKYLVMDEADRLLDMDFGPILDKILKVLPRERRTYLFSATMSSKVESLQRASLQNPLRVAVSSSKFQTVSTLQQSYIFIPHKHKDLYLVYLLNEFVGQSCIIFCRTVHETQRLSFFLRLLGFGAIPLHGQLSQSARLGALGKFRSRSRDILVATDVAARGLDIPSVDVVLNFDLPGDSKTFIHRIGRTARAGKSGVAISFATQYDVEAWLRIEGALGKKLPEYPAEKDEVMVLAERVSEAQRSAILEMKNYDEKKGSRGKKFAKGKRSREDMDQEEG
What is the function of this protein?
ATP-dependent rRNA helicase required for pre-ribosomal RNA processing.  Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent rRNA helicase rrp3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y268_BORBU
Sequence: MFISRELKYILLTSVSALFISAVLGLFCGLSFFTILVRSLLQFVFFFVIGLLIEYIFKKYLSNLFSTELSGNMENKPQDDKKSDKDFKENLDFQNKNSLYENSQNISSSGDFIEEVKKYKFETEDVSRGSDKNKKMSFIEDNDPKVVADAIKTLMSKKE
What are the official names of this protein?
Uncharacterized protein BB_0268, ORF36.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIMO_TRIV2
Sequence: MGEKPTIAISHLGCEKNRIDTEHMLGLLVKAGYGVDTNEELADYVIVNTCSFIESAREESVKTLVELAEANKKIVITGCMAQHFQTQLLEELPEAVAVVGTGDYHKIVNVIERAEQGERVTLVSAKPTYIADETTPRYRTTTEGVAYLRVAEGCDYRCAFCIIPHLRGNQRSRTIESIVAEAEQLVAQGVQEIILISQITTNYGLDIYGKPKLAELLRALGKINVPWIRMHYAYPTGLTPDVIAAIQETPNVLPYLDLPLQHSHSEVLRSMNRPWQGRVNDEIIERLKIAIPGAVLRTTFIVGFPGETEAQFEHLLQFVQRHEFDHVGVFTFSAEEGTPAYKLSNQLPQEVMDERRDRLMALQQPISWRKNQQEVGKTVEVLIEQENPESGKLIGRSGRFSPEVDGQVYVDGEAKLGTIIPVKIHSADEYDLFGQVVSHN
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_SHESR
Sequence: MAKKIDAYIKLQVKSGSANPSPPVGPALGQKGVNIMEFCKAFNARTEKMEKGMPIPVVITVYSDRSFTFETKTPPASYLLKTAAGLKSGSPRPNTQKVGTIARAKIQEIAELKAADMTGADVEAMTRSIEGTARSMGLVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: MOAC_ENT38
Sequence: MSQLTHINAAGEAHMVDVSAKAETVREARAEAFVTMLPETLAMIIDGSHHKGDVFATARIAGIQAAKRTWDLIPLCHPLMLSKVEVNLLADPEHSRVRIESLCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDMVIGPVRLLTKSGGKSGDFKADSHD
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: TRPB_OCEIH
Sequence: MTTYSFPNTKGKYGEFGGRFVPELLMPAVLELEKAYEDALKDESFNEELQTYLTEYIGRETPLYHAKKLTEHAGGAQIYLKREDLNHTGAHKINNTIGQALLTLRMGKKKVVAETGAGQHGVATATVCSLLGLECIVFMGEEDIKRQKLNVFRMELLGAEVVSVSQGSGTLKDAVNEALRYWVNNVNDTHYIIGSVVGPHPFPKIVRDFQSVIGKETKEQSMKKIGSLPDAVVACVGGGSNAMGMFYPFIDDKEVTLFGVEAAGAGLDTKQHAATLTGGSPGMLHGTFTYLLQDDCGQIEEAFSISAGLDYPGIGPEHSHLHQTKRVTYSSITDEEALEAFQLLSKTEGIIPALESAHAVSYATKLAKEMNPEQSIVICLSGRGDKDVEQVKERLEGEQ
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: NUSB_HELPS
Sequence: MATRTQARGAVVELLYAFESGNEEIKKIASSMLEEKKIKNNQLAFALSLFNGVLEKINEIDALIEPHLKDWDFKRLGSMEKAILRLGAYEIGFTPTQNPIIINECIELGKLYAEPNTPKFLNAILDSLSKKLAQKPLN
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: MURR_ECO57
Sequence: MLYLTKIRNAESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNATAQHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGCDLSFKLMKIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEWRSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIQRSSELTQRLK
What is the function of this protein?
Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc).  Binds to two adjacent inverted repeats within the operator region.  MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
What are the official names of this protein?
HTH-type transcriptional regulator MurR, MurPQ operon repressor.
Protein: PGK_SHEPC
Sequence: MAIINMSDLDLQGKRVLIREDLNVPVSNGVVTSDARLRASLPTIELALAKGAAVMVMSHLGRPTEGEYNSEFSMQPVVDYLAKALSSPVRLATDYLDGVEVAVGEVVVFENVRFNKGEKKNDEALSKKMAALCDVYVMDAFGTAHRAEASTNGVGLYAPIACAGPLLAQELNALGKALDNPARPMVAIVGGSKVSTKLTVLESLSGIVDQLVVGGGIANTFIAAAGHNVGKSLYEADLIDEAKRLVANAQSRGGDIPVPTDVVVAGEFSPTATATLKSVSDVSDSDMIFDIGPDSAEALAKIIESAGTIVWNGPVGVFEFDQFGEGTKRIAQAIADSKAFSIAGGGDTLAAVDKYGIADKVSYISTGGGAFLEFLEGKELPAVAMLKKRGA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPB_GADMO
Sequence: AGFPEQEPEPKFWNDWAQKTLDKALSLQTLNKNKAQNLILFLGDGMGVPTVTAARILKGQLRGQPGEEGQLEMDKFPFVALSKTYNTNAQVADSAGTATAYLCGVKANEGTVGVSAAAVRSQANTTQGNEVTSILRWAKDAGKSIGIVTTTRVNHATPSAAYAHCVDRDWYSDNEMPADAVEAGCKDIARQLFENIPDIDVIMGGGRKYMYPKNTTDVEYPGQPKHSGTRKDGRNLVKEWVDRNTEKKGHYVWNKKDLLSLNPTKVDYLLGLFEPADLPYDLERNKETDPSLSEMVEVAIKILRRNPNGFYLLVEGGRIDHGHHEGKDKQAIHEAVEMDRAIGRADLMTSTSDTLTVVTADHSHLFSFGGYTPRGNEIFGLAAFISDVDQKPFTAILYGNGPGYKLVNGARENVSTVDYQDNSYLAQAAVPLSSETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHAMAYAACIGQNR
What are the official names of this protein?
Alkaline phosphatase, AP.
What is the protein family that this protein belongs to?
Belongs to the alkaline phosphatase family.
Protein: UL79_ELHVK
Sequence: MTRVSSVSASCTTTNPPKNTREDMSRVGAHLTIQNDFRHLIMQITEKIFTKSSLGSMKFEELKIIHMGCQTVFMRGILTLLTRECFWNTGNDDIRILNRNIPTSYWLEIHTLLEKFIPTTDPWIFSDVYAENTLQYLQKQNACVRLYQEYMLSKLGLYVPLPDFLREDVNILFHLGTVTQHRLFKTFMIFQKYWGIDSYEPIVRTIVRKTWFFFLILWGQLRVDSNVFCEQDFGHEAGILSYLQSDYLSFMGIGQIDISINKSSFPDVFSITDIKPLM
What are the official names of this protein?
Protein U52.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL79 family.
Protein: RSMA_NITWN
Sequence: MSMIDDLPPLRDVIKRHALSARKSLGQNFLLDLNLTSRIARAAGPLQDATVVEIGPGPGGLTRALLAVGAKHVIAIERDERALGALEEISDRYPGRLTIINADATDFDPRPLLGTTRAKIVANLPYNIATALLIRWLSIEPWPPWYDVMVLMFQREVAERIVARENEDAYGRLGVLSNWRAETKILFDISPAAFVPQPQVTSSVVRLIPRYNPEPCDRRSLEQVAAAAFGHRRKMLRQSLKSLPADPASLAAAAGIDPTRRAETVSISGFAAMARELASIVGSGKRL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAMB_HIRME
Sequence: EGCKPCECDKSGSRLEQCNLYDGQCDCVDGRGGRDCSQCPEMSWGDPFLGCKSCTCNPDGARSLYCNKVTGQCECPRGVTGLNCDRCDRGTYGALPQCIPCGECFDNWDKLIAQLRDEAAAQLRIGTEIKLSGPPGAFAKEFEELEQVLMDMKSHVNSANVSSDQLENIDQELDNLSSKLKDLKPNLASHGSRTGEASVKISELYSRVLNLQSEFNKSSAKTKELRENALEIQEQDVSGAYASIQESLVKSSALQAKLTDAENSKNISVYFRTSVEHFLQNSNFSDANSENGNENSLDKVVEFMKAVDENVSSINTELCGGTGSPCHEDCGGAMCGKCGGELCGDGAVTKAVEAKNTSRKAEELIKSKYRSTSSTLSELENSNKQCKQATAEAKNNAHEA
What is the function of this protein?
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
What are the official names of this protein?
Laminin subunit B.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: YCF12_CYAM1
Sequence: MNWHVLAQLTVLAFVIAVGPITLIWLSNKKDALL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y2677_MYCBO
Sequence: MSPRRTSGGVVPVDRYRIDEGLIVVLVFAGRDERRRTVCFADKFGCVHIGNPDLYRPQTSLPQPLPISSHAISGSRFVETTNRADQQEPIGPNRAELFDQALHAG
What are the official names of this protein?
Uncharacterized protein Mb2677c.
Protein: ARP21_BOVIN
Sequence: MSEPGDLSQTIVEEGGPEQETATPENGVIKSESLDEEEKLELQRRLVAQNQERRKSKSGAGKGKLTRSLAVCEESSARPGGESLQDQTL
What is the function of this protein?
May act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.
What are the official names of this protein?
cAMP-regulated phosphoprotein 21, ARPP-21, Regulator of calmodulin signaling.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_PEDPA
Sequence: MAKKPKSNDKALAQNKKARHDYSILSTMEAGMVLTGTEIKSIRDRRVTLRDGYVQIRHGEAILMNVQINEYLQGNQFNHDPFRNRKLLLHKKEILKLQEETKNKGITIVPLKMYLKNGFAKVLIGVAKGKHEYDKRESLKKRDQQREIDRALKNR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: BG4_ARATH
Sequence: MLYSPKKLFLFFLSCIVLYVNSNNSGFVTAANSIGLNYGLLGDNLPSPSNVINLYKSIGISRIRIFDPNTEVLNALRGHRDIEVTVGVKDQDLAALAASEEAVKGWFAANIESYLADVNITFITVGNEVIPGPIGPQVLPVMQSLTNLVKSRNLPISISTVVAMSNLEQSYPPSAGMFTSQAREQLVPVLKLLSQTSTPILVNIYPYFAYASDPANIRLDYASFNTKSIVVQDGSLGYSNMFDAIFDAFVWAMEKEGVKNLPMVVSETGWPSAGNGNFTTPAIASTYNRNFVKHIASGKGTPKRPNKSMNGFLFATFNENQKPAGTEQNFGLYNPSDMKPIYKLF
What is the function of this protein?
May play a role in plant defense against pathogens.
What are the official names of this protein?
Probable glucan endo-1,3-beta-glucosidase BG4, Beta-1,3-glucanase 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYA_HELAH
Sequence: MDIRNEFLQFFKNKGHEIYPSMPLVPNDSTLLFTNAGMVQFKDIFTGMVPHPSIPRATSSQLCMRAGGKHNDLENVGYTARHHTLFEMLGNFSFGDYFKEEAILFAWEFVTKNLGFKPKDLYISVHEKDDEAFKLWEKFVPTDKIKKMGDKDNFWQMGDSGPCGPCSEIYIDQGEKHFKGSEDYFGGEGDRFLEIWNLVFMQYERSNDGILSPLPKPSIDTGMGLERVQALLEHKLNNFDSSLFVPLMKEISELTSLDYASEFQPSFRVVADHARAVAFLLAQGVHFNKEGRGYVLRRILRRSLRHGYLMGLKEAFLYRVVGVVCEQFADTHAYLKESKEMVMKECFEEEKRFLETLESGMELFNLSLKHLNDNKIFDGKIAFKLYDTFGFPLDLTNDMLRNHGACVDMQGFESCMQEQVKRSKASWKGKRNNADFSTILNAYAPNVFVGYETTECFSQALGFFDSDFKEMTETNPNQEVWVLLEKTPFYAEGGGAIGDRGALLKDDEEAALVLDTKNFFGLNFSLLKIKKALKKGDQVIAQVSNERLEIAKHHSATHLLQSALREVLGSHVSQAGSLVESKRLRFDFSHSKALNDEELEKVEDLVNAQIFKHLSSQVEHMPLNQAKDKGALALFSEKYAENVRVVSFKEASIELCGGIHVENTGLIGGFRILKESGVSSGVRRIEAVCGKAFYQLAKEENKELKNARILLKNNDLIAGINKLKESVKNSQKASVPMDLPIETINGTSVVVGVVEQGDIKEMIDRLKNKHEKLLAMVFKQENERISLACGVKNAPIKAHVWANEVAQILGGKGGGRDDFASAGGKDIEKLQAALNAAKNTALKALEK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAG_MYCS2
Sequence: MPVAGGRIPDRDIAAIREKVRIEDVVGDYVQLRRAGADSLKGLCPFHDEKTPSFHVRPNHGHFHCFGCGEGGDVYAFIQKIEHVSFVEAVELLADKVGYTVTYTGSSTTNVQRDRGSRSRLLAANAAAAEFYAEALQSEEAAPARQYLTERNFDAAAAAKFGCGYAPSGWDKLTKHLLRKGFEFKELEAAGLSREGKRGPMDRFHRRLLWPIRVSSGETIGFGARRLFDDDPNQAKYVNTPETVLYKKSQVLFGLDLAKRDIAKGHQAVVVEGYTDVMAMHLAGVTTAVASCGTAFGEQHLSMLRRLMMDDNFFRGELIYVFDGDDAGRAAAVKAFEGEQNLSGQSFVAVAADGMDPCDLRLRSGDGALRDLVARRTPLFEFVIRSALAEHDLDSAEGRVAALRRCVPMLARIKDPTLRDEYARQLAGWVGWDNVAQVIGRVREEAKGGGRKDNNRRGQETAARPKPPPVQRPDPTDPTLWPQREALKAGLQYPALAGPVFDTLTVESFTHPGYGAVRTAMEAAGGTSAGITGAQWIETVREQTTSPAAANLVNELSVETINVEDDEKLPRYISSVLARLQEVWVGRQIAEVKSKLQRMSPVEQGDEYHALFGDLVAMESYRRSLLEQASGDDLTA
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the DnaG primase family.
Protein: VRAA_STAEQ
Sequence: MKKIMEYLQHYINQYPHRLALVFEDRHLTYGELSKEIYQASMRYKEVKLNEKVGLMDDHPVNNIINYFAVHQRGGIPCIFNHQWSNERIHQLVKSYDIQWLIKDNHLTLNHDDSIYNDEVIPRNVIHIGFTSGTTGLPKAFYRNEHSWIVSFKENEKLLQHCEETIVAPGPLSHSLSLYACIYALSTGKTFIGQKNFNPLSLMRLINQLNKATAIFVVPTMVQQLISTQRHCSSIKSILSSGAKLTLQQFQQISTLYPQANLIEFFGTSEASFISYNFNQSSPAHSVGKLFPHVETRLLNQDDDAVGLLAVRSEMVFSGYVGQSNQEGSWIKTGDFAYIKNQHLFLVGRESDRIIVGGINVYPTAIESLIMDIEGIDEALVIGIPHAKFGEIAILLYSGKVQLNYRQIKSFLMKQLSRQEVPSKLKKIDHMIYTESGKIARKEMKNKFINGEL
What are the official names of this protein?
Putative long chain fatty acid-CoA ligase VraA, Acyl-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: YHIT_SACS2
Sequence: MCIFCNIVEGRDHGYIVYSNDRVVAFLDKFPITPGHTLVVPRTHYENFLEISEDVIPYLCTAVRKISIAVKKALKADGIRILTNIGKSAGQVVFHSHFHIVPTWSQDPDIMKDFVPRKEQSREYYEYVQKAIIETLKNI
What are the official names of this protein?
Uncharacterized HIT-like protein SSO2163.
Protein: PHNH_PENHR
Sequence: MKFTYLVSLAAFAVTALGSRPTPPNLEFLFSANLTKGPAYIYDQSDAQIKALQTLTGGIIAGPNFDGTVIGGTALSTRGADGTIRADAHYLIQTSDGANILVTESAAIPYVAVLFDTSSEKYNWLNNVTAWGTPPNLNEINFLEYWQIE
What is the function of this protein?
Hydroalkoxylation enzyme; part of the gene cluster that mediates the biosynthesis of phenalenones such as herqueinone, compounds that have been reported to treat tumors, bacterial infections and/or mycoses, and rheumatic diseases (PubMed:26978228).  The non-reducing polyketide synthase phnA synthesizes the heptaketide backbone and cyclizes it into the angular, hemiketal-containing naphtho-gamma-pyrone prephenalenone.  The product template (PT) domain of phnA catalyzes only the C4-C9 aldol condensation, which is unprecedented among known PT domains (PubMed:28240554, PubMed:26978228).  The transformation of prephenalenone to phenalenones requires an FAD-dependent monooxygenase phnB, which catalyzes the C2 aromatic hydroxylation of prephenalenone and ring opening of the gamma-pyrone ring simultaneously (PubMed:28240554, PubMed:26978228).  Subsequent intramolecular deprotonation of C3 phenolic oxygen accelerates phenalenone ring closure to yield the tricyclic phenalenone core with a C2 hydroxylation (PubMed:28240554, PubMed:26978228).  The prenyltransferase phnF further catalyzes reverse C-prenylation of phenalenone by direct electrophilic substitution at C6, or possibly via first a forward O-prenylation of a neighboring phenol in phenalenone, followed by a Claisen rearrangement (PubMed:28240554).  The hydroalkoxylation enzyme phnH catalyzes the 5-exo-trigcyclization via acid catalysis after the spontaneous deprotonation of 7-OH, which leads to the formation of the dihydrobenzofuran atrovenetin (PubMed:28240554).  Atrovenetin is further converted to deoxyherqueinone by the O-methyltransferase phnC which can methylate C2-OH to stabilize the northern portion of the phenalenone core (PubMed:28240554).  Finally, the oxidoreductase phnG converts deoxyherqueinone to herqueinone via C6 hydroxylation (PubMed:28240554).
What are the official names of this protein?
Hydroalkoxylation enzyme phnH, Phenalenone biosynthesis cluster protein H.
Protein: TFCP2_MOUSE
Sequence: MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDNENEILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPELNGKLVKSIFRVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGVIDPRANPTQLNTVEFLWDPSKRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENGNGEYTEHLHSASCQIKVFKPKGADRKQKIDREKMEKRTPHEKEKYQPSYETTILTECSPWPEITYVNNSPSPGFNSSHSSFSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFSGADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQPQPQPQPQKQEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSISPHQISQIYKQGPTGIHVVISDEMVQNFQEEACFILDTMEAETSDSYHVILK
What is the function of this protein?
Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters.  Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity).  Functions as part of the SSP (stage selector protein) complex.  Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells.  Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity).
What are the official names of this protein?
Alpha-globin transcription factor CP2.
What is the protein family that this protein belongs to?
Belongs to the grh/CP2 family. CP2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HKT21_ORYSJ
Sequence: MTSIYHDFIHNKLQSFGRIGRYFVNFVVLAHRFIALHIHPFWIQLSYFLLISILGSVLLMFLKPSNPEFRPGYIDMLFLSTSALTLSSLITIEMEVLSSSQIVVITLLMLLGGEVFVSFLGLMLRLNHKHNPEFSGDKVSSVPIELDTINSASTVISCEELQLEAAIPEVPSSTIKDLKRSKRLRWFLGFVVFSYFVVIHVAGFLLVLWYISRVSSAKAPLKKKGINIALFSFSVTVSSFANVGLVPTNENMAIFSKNPGLLLLFIGQILAGNTLYPLFLRLLIWFLGKVTKLRELKLMIKNPEELQYDYLLPKLPTAFLASTVIGLMASLVTLFGAVDWNSSVFDGLSSYQKIINALFMAVNARHSGENSIDCSLIAPAVLVLFIILMYLPPSTTFALSNGDEKTANKKAKRKLGLVVQNLAFSQLACISVFVIVAFITERSRLRNDPLNFSALNMIFEIISAYGNVGLSTGYSCSRLQKLHPGSICQDKPYSLSGWWSDEGKLLLVFVMLYGRLKAFTKGTGEYWRLW
What is the function of this protein?
Seems to be involved in regulation of potassium-sodium homeostasis (PubMed:11489190, PubMed:12795699, PubMed:11959905).  Functions as a high-affinity sodium transporter, which mediates increased sodium uptake in roots under potassium deficiency and contributes to sodium accumulation and salt toxicity (PubMed:11489190, PubMed:12795699, PubMed:11959905).  Involved in nutritional sodium uptake and distribution in potassium-starved roots to allow plant growth (PubMed:17541409, PubMed:30854552).  Functions as sodium-potassium cotransporter (PubMed:19482918).
What are the official names of this protein?
Cation transporter HKT2;1, OsHKT2;1, Cation transporter HKT1, OsHKT1, Ni-OsHKT1.
What is the protein family that this protein belongs to?
Belongs to the TrkH potassium transport family. HKT (TC 2.A.38.3) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the plasma membrane.
Protein: IOLA_LISMC
Sequence: MADVRKLKNYINGEWVESRADKYEDVINPATGEVLCQVPISTRAELDQAAVIAEQAFEKWSQVAVPRRARVLFSFQQLLIQHKEELARLITLENGKNLSEARGEVQRGIENVEFAAGAPTLMMGDSLASIATDVEAANYRYPVGVVGGIAPFNFPMMVPCWMFPMAIALGNSFILKPSERTPLLMEKLVELFSEAGLPKGVFNVVYGAHDVVNGILENEIIKAVSFVGSKPVGEYVYKTGSANLKRVQALTGAKNHTIVLNDADLEDTVTNVISAAFGSAGERCMACAVVTVEEGIADEFLAALRTAAQNVKIGNGLDDGVFLGPVIREENQKRTIAYIEKGLEEGAKLTVDGRETGLSEGHFVGPTILEDVTTDMTIWKDEIFAPVLSVIRVKNLQEAVRVANQSEFANGACIFTNNAKAIRYFREKIDAGMLGVNLGVPAPMAFFPFSGWKSSFYGTLHANGKDSVDFYTHKKVVTARYSLKGYEE
What is the function of this protein?
Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.
What are the official names of this protein?
Malonate-semialdehyde dehydrogenase, MSA dehydrogenase, Methylmalonate-semialdehyde dehydrogenase, MMSA dehydrogenase, MSDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. IolA subfamily.