PharMolix/UniProtQA huggingface dataset:
Protein: MUTS_RHIWR
Sequence: MFARLAFGAWPGSPQVAISVRMAQTAKKDMAPPASAPTPMMAQYLALKAAAEDCLLFYRMGDFFELFFDDAKTASACLDIALTARGEHDGQPIPMCGVPAHSAEGYLARLIKAGHRVAIADQTESPAEAKKRAGSKALVGRAIVRVVTAGTLTEEALLDSRAANWLVAVAGAGQGADRRIGIAAADISTGRFEIAGLIPSALDAELARLDAAEIVVPEDFEEPPAGAVAWPREHFESVRGEERLKRLLGVATLDGFGAFTRAELAAAGALIAYLERAGQGSLPFLQPPRRRVVADHMMIDAATRESLEITLSQAGVRKGSLLDAVDRTVTGAGARLLGADLSAPLTDVGAIEARLDLVALFEGDGALRERLRGALRALPDVGRALGRLVARRGSPRDLGQLRDGLDQARLLHELLGRAAPMPALLAGLLPQLVGHDELVDLLRRALVATPPIDAAQGGYIAEGYDPALDALRGQGGEGRKAIAALEARYRAETGIPSLKIKHNGVLGYHIEVQAKHADPLMTADSGFTHRQTLAGVVRFNAPDLHEQAMRVGQSGEHALAAEAAHLEELMAAALGRTAEIAATADALARLDVAAALAERAAEGGWTRPHFEPHSCFDVIGGRHPVVEAAVAAQGARFVANDCRLSDQERLWLVTGPNMGGKSTFLRQNAAIAILAQAGSPVPATSARLGIVDRLFSRVGASDNLARGRSTFMVEMVETAAILAQATERSFVILDEVGRGTSTYDGLAIAWAVVEAVHDINRCRCLFATHYHELTRLAERLDALSLHHVRAREWKGELVLLHELADGPADRSYGIAVAKLAGLSPPVLARARDVLKKLEAGRAATGGLAAGLDDLPLFAAAAQVEEAAPDPLRHEIETIDVDSLSPREALDILYRLKTLAREAAE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: FUCI_SALA4
Sequence: MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALITEKIRHACGAQVECVIADTCIAGMAESAACEEKFSSQNVGVTITVTPCWCYGSETIDMDPMRPKAIWGFNGTERPGAVYLAAALAAHSQKGIPAFSIYGHDVQDADDTSIPADVEEKLLRFARAGLAVASMKGKSYLSVGGVSMGIAGSIVDHNFFESWLGMKVQAVDMTELRRRIDQKIYDEAELEMALAWADKNFRYGEDQNASQYKRNEAQNRAVLKESLLMAMCIRDMMQGNKTLADKGLVEESLGYNAIAAGFQGQRHWTDQYPNGDTAEALLNSSFDWNGVREPFVVATENDSLNGVAMLFGHQLTGTAQIFADVRTYWSPEAVERVTGQALSGLAEHGIIHLINSGSAALDGACKQRDSEGKPTMKPHWEISQQEADACLAATEWCPAIHEYFRGGGYSSRFLTEGGVPFTMTRVNIIKGLGPVLQIAEGWSVELPKAMHDQLDARTNSTWPTTWFAPRLTGKGPFTDVYSVMANWGANHGVLTIGHVGADFITLAAMLRIPVCMHNVEEAKIYRPSAWAAHGMDIEGQDYRACQNYGPLYKR
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPS1_MACFA
Sequence: MKCVLVATEGAEVLFYWTDDEFEESLRLKFGQSENEEEELPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGNSLYVLHLFGECLFIAINGDHTENEGDLRRKLYVLKYLFEVHFGLVTVDGQLIRKELRPPDLGQRVQLWEHFQSLLWTYSRLREQEQCFAVEALERLIHPQLCELCIEALERHVIQAVNTSSERGGEEALHAFLLVHSKLLAFYSSHSASSLRPADLLVLILLVQDLYPSENTVEDDTQETDSFSLPEEYFTPAPSPGDQSSGSTIWLEGGTPPMEALQIAEDTLQTLVPHCPAPSSPRRIFLDANVKESYCPLVPHTMYCLPLWPGINLVLLTRSPSAPLALVLSQLMDGFAMLEKKLKEGPEAGASLRSQPLVGDLRQRMDKFVKNRGAQEIQSTWLEFKAKAFSKSEPGSSSELLQACGKLKRQLCAIYRLNFLTTAPNRGGPHLPQHLQDQVQRLMREKLTDWKDFLLVKSRRNITMVSYLEDFPGLVHFIYVDRTTGQMVAPSLNCSEKTSSELGKGPLAAFVKTKVWSLIQLARRYLQKGYTTLLFQEGDFYCSYFLWFENDMGYKLQMIEVPVLSDDSVPIGMLGGDYYRKLLRYYSKNRPAEAVRCYELLALHLSVIPTDLLVQQAGQLARRLWEASRIPLL
What is the function of this protein?
Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form.  The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.
What are the official names of this protein?
BLOC-3 complex member HPS1, Hermansky-Pudlak syndrome 1 protein homolog.
Protein: EFPL_ECO24
Sequence: MPRANEIKKGMVLNYNGKLLLVKDIDIQSPTARGAATLYKMRFSDVRTGLKVEERFKGDDIVDTVTLTRRYVDFSYVDGNEYVFMDKEDYTPYTFTKDQIEEELLFMPEGGMPDMQVLTWDGQLLALELPQTVDLEIVETAPGIKGASASARNKPATLSTGLVIQVPEYLSPGEKIRIHIEERRYMGRAD
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: Y282_TREPA
Sequence: MHEQRRGIVRVDRFLELHRRLLVGVLVAILGGLGLSAGCLLVMTRLRARASAEVTRIAREWDVLRKPDNTVSASGHEVEGRGGSSIRAKEDALLARLESCASSPWRDGFAYAYAQACVADIFFARKEWEKAQQAYVRAAYGARRSYVAGVYYFNAASCADERGRFEEARELYQRSARVQDFPLVPRALFNVGRMEEALGRAAAATAAYMQLYERFPLNGWAALGKSRAIAISVGGGRAQ
What are the official names of this protein?
TPR repeat-containing protein TP_0282.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: Y871_EXISA
Sequence: MGQILLILLLQLIYVPVLTLRTIMLVKGKTVIAGLFGTLETLIYIFALGIVFQDLTTVGMIVYAVGFGLGILLGGFVERKLAIGYNMIQVHTKEYPAELIQQMRDNGYGVTHYQGQGRDGVRYRLDVLAARTRMKELRELVEKHEPKAFLVAFDPIDFKGGYMMKGLRRPK
What are the official names of this protein?
UPF0316 protein EAT1b_0871.
What is the protein family that this protein belongs to?
Belongs to the UPF0316 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TPMT_FRATN
Sequence: MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLFFLSKGVKVVGIELSEKAVLSFFSQNSINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIANNLPAFDIWYDRGAYIALPNDLRTNYAKMMLEVCPNNTQILLLVMEHDKKSQTPPYSVTQAELIKNFSAKIKFELIDSKQRDNIPDYRKAEGMTKQYYTTYLRKKQY
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_DESPS
Sequence: MRRDETIYILRPTMSEEHINTVIENTNKIILDDAGTIIFYEPSGAUKSLLTUSRKSSQGYYVYCDYAGTPAAVSEMERRFRIEDAVLKYMTVKLSEDISAEEIQQAIGDIAAREAAVKEAAEAEEAANEEVVEKVVEKVAEKAAEKTVEEAAPVKETEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: BIOB_CLOB8
Sequence: MEKLAEEIINGRRLTRSDDLEFLLTCDLKKICDGANKIRKTLCGESVDLCTIINGRSGKCSENCKFCAQSNHHKTEIKKYDFLDPNVILKDCKKNEANGVHRYSIVTAGRALVGSDFDKAVQAYKMMNKECSINLCASHGFLSEEQFVLLKEAGVTMYHANIETSKRNFHNICTTHSYDDKIKEIKLAQNAGLKVCSGGIIGMGETWYDRIDMAISLSELGVISIPINVLMPIKGTPLENLKRISNYDILRTIAIFRYINPTAYIRMAAGRTYFEDGGIEIFQSGSNATITGDMLTTVGNNTCQDKIMLQTLGFSI
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: ERGI2_MACFA
Sequence: MRRLNRKKTLSLVKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITVAMKCQYVGADVLDLAETMVASADGLVYEPAVFDLSPQQKEWQRMLQLTQSRLQEEHSLQDVIFKSAFKSASTALPPREDDSSQSPDACRIHGHLYVNKVAGNFHITVGKAIPHPRGHAHLAALVNHESYNFSHRIDHLSFGELVPAIINPLDGTEKIAIDHNQMFQYFITVVPTKLHTYKISADTHQFSVTERERIINHAAGSHGVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIVGGIFSTTGMLHGIGKFIVEIICCRFRLGSYKPVNSVPFEDGHTDNHLPLLENNTH
What is the function of this protein?
Possible role in transport between endoplasmic reticulum and Golgi.
What are the official names of this protein?
Endoplasmic reticulum-Golgi intermediate compartment protein 2.
What is the protein family that this protein belongs to?
Belongs to the ERGIC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Cycles between the endoplasmic reticulum and the Golgi.
Protein: ELAA_SHIFL
Sequence: MIEWQDLHHSELSVSQLYALLQLRCAVFVVEQNCPYQDIDGDDLTGDNRHILGWKNDELVAYARILKSDDDLEPVVIGRVIVSEALRGEKVGQQLMSKTLETCTHHWPDKPVYLGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMAREVIQA
What are the official names of this protein?
Protein ElaA.
What is the protein family that this protein belongs to?
Belongs to the UPF0039 (ElaA) family.
Protein: RR18_SECCE
Sequence: MYTSKQPFLKSKQPFSKSEQPFSKSEQPFRKSKQTFRKFKQPFRKSKQPFRRRPRIGPGDRIDYRNMSLINRFISEQGKILSRRINRLTLKQQRLITLAIKQARILSFLPFRNYENEKQFQAQSISIITGSRPRKNRHIPQLTQKYNSNRNLRNNNQNLRNNNRNLSSDC
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RIB7_DEBHA
Sequence: MSLLPLTPSLRPFLEEYLPRPCSNRPFVTLTYAQSLDSRIAAKPGEQTKISHLETKTMTHYIRSKHDGIMVGIGTVLADDPKLNCRFEAEDGNISTPRPIILDPTGKWAYHKSQLRSVCDNNKGLAPFILIDETVTPRNEDVEVLDKQDGAFVRLPLLRNADKVGNWNIILKKLFQLGIKSIMVEGGASIINDLLVYSKIIDSLIITIGPVFLGKDGVEVSPSGHAGLIDVKWWQGIQDSVLCARLT
What is the function of this protein?
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
What are the official names of this protein?
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, DAROPP reductase, DARP reductase, 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase, 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase, DARIPP synthase.
What is the protein family that this protein belongs to?
Belongs to the HTP reductase family.
Protein: NHR98_CAEEL
Sequence: MSAAARTFISIHIGVCFDEMDSPGSSAPSPPDLTIIPKISSKKCQICENPAHGKHFGAVTCRACAAFFRRFGISNNFKPCKTENKCSFRKNGYFSCKKCRMQRCLQFGMTIDNFQFDREPFNPLKMNVGIPQTVDTFSGRPSLILFSAPSGSSGPKRYIDVQFLVDRAVEVLLNGSETPYQVSNVLQKLAIGLQNIRGPQQKVSQIVTKIGKEGIFKLWEEEMLRMAKWLTYFDDFQRLPHSVQIEILNGVWFLFGRLENIASTALARKRKLCKDDMVMTCVNKNVLICDLRTLEIDLSWCSKYTFQQLKFFDQYDDLRQLDILINAMLDLEPTHEELSYMICQLCFHQVGKKLQGNILKTVEKLQEVLSNNLHDYYVNQMNQPKYSKRIARMMKINNTVEQCLYRDRVKADLMKVFEVFHVECSHPGIFLNA
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-98.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYW_BUCAI
Sequence: MILSKPILLSAVQPSGNLTIGNYIGTMRHWSKMQNNYECLYCIADLHALTIQKNKIHLNKSILDTISFYLSCGVDPQKSIIFIQSHVYQHSQLNWILNCFSQFSELLRMTQFKIKSNCSKKINAALFNYPILMAADILLYQTNFVPVGQDQKQHVELTRNIAHRFNSLYGHVFTLPKPLITQHGSKIMSLLEPSKKMSKSDINKKNVIFLLDDIKTVISKIQNAYTDSETPSKIYYDIEKKPGISNLLEILSAITNKDIDILLKELEGMLYSEFKNIVADHLSKFLYKLQKSYNDYRNDEVYLKKIAYEGAMKSQLKSNKTLTKVYDKLGLIPLF
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIN1_BOVIN
Sequence: MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPNSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKISGPQYRLEKQSEPNVAVDLESTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTSQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
What is the function of this protein?
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals.  mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive.  mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.  mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.  mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation.  mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'.  mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.  Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity.  MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation.  Inhibits HRAS and KRAS signaling.  Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription.  Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity).
What are the official names of this protein?
Target of rapamycin complex 2 subunit MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, Stress-activated map kinase-interacting protein 1, SAPK-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the SIN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Protein: VATG2_MACMU
Sequence: MASQSQGIQQLLQAEKRAAEKVADARKRKARRLKQAKEEAQMEVEQYRREREQEFQSKQQAAMGSQGNLSAEVEQATRRQVQGMQSSQQRNRERVLAQLLGMVCDVRPQVHPNYRISA
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons.  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
What are the official names of this protein?
V-type proton ATPase subunit G 2, V-ATPase subunit G 2, Vacuolar proton pump subunit G 2.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase G subunit family.
What are the subcellular locations of this protein?
Melanosome. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Note=Highly enriched in late-stage melanosomes.
Protein: ALLA_CHESB
Sequence: MRKIIAEPLTKDAFAPFGDVIEAEEGTSFPINNGKTQRFHDLAKVEVGGENARVMVSIARGQPYDLPLTLNMVERHPLGSQAFMPLTSSPFLVIVCPDESGRPGVPRAFITKPGQGVNYARNTWHGVLTPIGEEQDFLIVDRGGEGNNLEEFFFPEPYEIHLPER
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: ENSA_PIG
Sequence: MSQKQEEENPAEETGEEKQDTQEKEGILPEKAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE
What is the function of this protein?
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.  When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.  Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity).
What are the official names of this protein?
Alpha-endosulfine, ARPP-19e.
What is the protein family that this protein belongs to?
Belongs to the endosulfine family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPNE6_BOVIN
Sequence: MSDPEMAWVPEPPAMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLHSDEQWVEVERTEVLRSCSSPVFSRVLALEYFFEEKQPLQFHVFDAEDGSTSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKNAGKSTITIVAEEVSGTNDYVQLTFRAHKLDNKDLFSKSDPFMEIYKTNGDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKHYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAGPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGTLRCPRGVPAARDIVQFVPFRDFKDASPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTPAMTPSPSP
What is the function of this protein?
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes.  Binds phospholipid membranes in a calcium-dependent manner.  Plays a role in dendrite formation by melanocytes.
What are the official names of this protein?
Copine-6, Copine VI.
What is the protein family that this protein belongs to?
Belongs to the copine family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Perikaryon. Cell projection, dendrite. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner.
Protein: SSRP_BUCA5
Sequence: MLQKKKYQKKSSKIIINKKAYYNYFIEKVFQSGLVLEGWEIKSIRSGKVNISESYIINDRNEMYLCNCLIEPLQMSSNRFSCDPTRKKKLLLHKNEIDFLSLKKKNTGYTMVSLSLFWKKSWCKLEFGLAKGKTAQDKRINLKKREWEQEKLKILKKTKETY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CYC24_RHOPL
Sequence: QDAAKGEALFKQCQTCHRADKNMVGPALAGVVGRKAGTAPGFSYSPLNHAAGEAGLVWSQENVVEYLADPNAFLKKFLTDKGQADKATGSTKMTFKLANEQQRKDVAAYLATLK
What is the function of this protein?
Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway.  However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.
What are the official names of this protein?
Cytochrome c2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Periplasm.
Protein: LSM5_DICDI
Sequence: MSEVENSNTVDLQSQLLPLELIEKCIGSRIWIAMKNDKEFVGTLLGFDAYVNIFLKDVTEYEYTPEGLKTVKLDNILLNGNHVCLLVPGGEGPKVKA
What is the function of this protein?
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).  The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
What are the official names of this protein?
Probable U6 snRNA-associated Sm-like protein LSm5.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCH1_ECOLI
Sequence: MPSLSKEAALVHEALVARGLETPLRPPVHEMDNETRKSLIAGHMTEIMQLLNLDLADDSLMETPHRIAKMYVDEIFSGLDYANFPKITLIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILIALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRHEFLRAVRHHN
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: CRJ33_CRYJA
Sequence: RAIGVWIALVAALSVFLHGMEVRAATFDITNQCPYTVWAAASPGGGQQLDQGQTWTIQVAAGTTQARIWARTGCSFDGSGRGTCQTGDCNGMLSCQGYGQVPATLAEYALNQYMNLDFYDISLVDGFNVPLSMTPTSTDPNCKGRIACLSDINSQCPSDLKVTGGCKSACARYNTPEYCCTGASENTCGPTDYSKFFKGQCPQAYSYAKDDATSTFTCPSGTNYKVVFCG
What is the function of this protein?
May be involved in disease resistance.
What are the official names of this protein?
Pathogenesis-related thaumatin-like protein 3.3.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
Protein: NGRN_PONAB
Sequence: MAVTLSLLLSGRVCAAVARCGFATRGVADPGPIGREPDPDSDWEPEERELQEVKSTLKRQKKAIRFQKIRRQMEASGAPPRTLTWEAMEQIRYLHEEFPESWSVPRLAEGFDVSTDVIRRVLKSKFLPTLEQKLKQDQKVLKKAGLAPLLQQLRGSGNTSKLLPAGHSVSGSLLMPGHEASSKDPNHSTALKVIESDTHRTNTPRRWKGRNKEIQDLEESFVPVAAPLGHPRELQKYSSDSESPRRTGNGALPSDQKLEELKAEEPGNFSSKVVQRGREFFDSNGNFLYRI
What is the function of this protein?
Plays an essential role in mitochondrial ribosome biogenesis.  As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
What are the official names of this protein?
Neugrin, Neurite outgrowth-associated protein.
What is the protein family that this protein belongs to?
Belongs to the neugrin family.
What are the subcellular locations of this protein?
Nucleus. Secreted. Mitochondrion membrane.
Protein: MEA1_MOUSE
Sequence: MAAVVLGGDTMGPERIFPNQTEDLGPHQGPTEGTGDWSSEEPEEEQEETGAGPAGYSYQPLNQDPEQEEVELAPVGEGEDGAADIQDRIQALGLHLPDPPLESEDEDEEGAAALSSHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWAREISDAQWEDVVQKALQARQASPAWK
What is the function of this protein?
May play an important role in spermatogenesis and/or testis development.
What are the official names of this protein?
Male-enhanced antigen 1, MEA-1.
Protein: G6PI_ACTP7
Sequence: MQNINPTQTAAWSALEQHKADNLNIPQLFAEDANRFDKYHLNFEQQILVDFSKNAINQKTLELLRQLANECGLASATEAMFSGQKINRTENRAVLHTALRNRSNTPVLVDGKDVMPEVNAVLAKMKDFCERIISGSWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLVLVASKTFTTQETMTNALTAREWLLAAVKDESAVAKHFAALSTNAKEVAKFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFENFEALLSGAHAMDNHFRTAPIEKNIPTTLALIGIWNSNFLGAETEALLPYDQYLHRFAAYFQQGNMESNGKFVGRDGSPVTHQTGPIVWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAQTHNPVGDHHAKLLSNFFAQTEALAFGKSKETVEAEFVAAGKNLADVAEIVPFKVFTGNKPTNSILVQKITPFTLGALIAMYEHKIFVQGVIFNIYSFDQWGVELGKQLANRILPELQNAEKISSHDSSTNGLINQFKAWR
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SACDR_RAT
Sequence: MRFLRWIRQIWRKVPNWVLFWKHLAKPGLSDQREKHLLKGPEKTSKDFDTVKLANAQKEDMVSDLDVCPGVLRSVKERSPLHDRESRSSRDSRSLMTVVNSVSTFMFSVLQSGWRLCRWKSSMSTGKVSSHTRTGSALGTPEAEMLREVYLVLWVIRKQLRELARRQERRRRRRMRSHASHTSRHSESVQGLKHDARSPL
What is the function of this protein?
May play an important role in acrosome formation and nucleus shaping during spermiogenesis.
What are the official names of this protein?
Sperm acrosome developmental regulator.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Detected in acrosome of round spermatids and spermatozoa.