PharMolix/UniProtQA huggingface dataset:
Protein: RS7_AROAE
Sequence: MPRRREVPKREILPDPKFGSQDVSKFINVIMQAGKKSVAERIVYGAFAQISGKAGKDPLEVFSSAVANVKPVVEVKSRRVGGANYQVPVEVRPSRRMALSMRWLREAARKRAEKSMAQRLAGELLEAAEGRGSAMKKREEVHRMAEANKAFSHYRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: YZ19_AQUAE
Sequence: MERIRMKTLEKSLEDSLKIYVSEALYTDIEDFKVDYPTALDFELTQVLLIREDLAKNKENIPQQLLDEIRQADKRYLDLYEQVKDLKTKNPHIQVAIKVLKALVELIKTEPI
What are the official names of this protein?
Uncharacterized protein aq_aa19.
Protein: O168_CONVX
Sequence: MKLTCVLIITVLFLTASQLITADYSRGQRQYRAVRLGDEMRNFKGARDCGGQGEGCYTQPCCPGLRCRGGGTGGGSCQP
What are the official names of this protein?
Conotoxin 8.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VL1_HPV33
Sequence: MSVWRPSEATVYLPPVPVSKVVSTDEYVSRTSIYYYAGSSRLLAVGHPYFSIKNPTNAKKLLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGISGHPLLNKFDDTETGNKYPGQPGADNRECLSMDYKQTQLCLLGCKPPTGEHWGKGVACTNAAPANDCPPLELINTIIEDGDMVDTGFGCMDFKTLQANKSDVPIDICGSTCKYPDYLKMTSEPYGDSLFFFLRREQMFVRHFFNRAGTLGEAVPDDLYIKGSGTTASIQSSAFFPTPSGSMVTSESQLFNKPYWLQRAQGHNNGICWGNQVFVTVVDTTRSTNMTLCTQVTSDSTYKNENFKEYIRHVEEYDLQFVFQLCKVTLTAEVMTYIHAMNPDILEDWQFGLTPPPSASLQDTYRFVTSQAITCQKTVPPKEKEDPLGKYTFWEVDLKEKFSADLDQFPLGRKFLLQAGLKAKPKLKRAAPTSTRTSSAKRKKVKK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: HEM1_HAES1
Sequence: MTILVLGINHKTASVALREKVAFSDEKRLLALKQIKQTQLAESAVILSTCNRTEVYLHNKNVGPQNDEVWLDSCVQWFADIHQVDLEELKSCLYSQQNLQASRHLMRVASGLDSLILGEPQILGQVKQAYQMSEEYYSLHSDIGMMSTELSRLFQKTFATAKRVRTETHIGESAVSVAYAACSLARQIFDSLRNLNILLVGAGETIELVSRHLLRHGVNGLAIANRTLSRAEKLVEKLETTQKIDIFSLDRLSEGLKRADIVITSTGSPHVLISRNLIEQAQQMRHYKPMLIVDIAVPRDVEESAGEIESVYHYTVDDLHNIIQYNINQREQASQQAEHIIQQESADFFEWLKVHQFSNLIRNYRESAEIIRQDLLEKALQALQNGENTEQVLQELSHKLTKKLIHQPTQAMQTMVKAGNTEGLQAFSHAVKF
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RBSD_CALS4
Sequence: MKKTELLNSEISEVVARLGHKDLLVIADSGLPIPDNVKRIDIALTKGIPSFRDTLNTVLTELGVEKAYVAREMIDKNKKLYLELSEQFGDKLVIIDHEQLKEMCKNAKAVIRTGEYTPYANIVLESGVEF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THG1_DEBHA
Sequence: MAKSRFEYVKQFERENFLLPDTYLIVRVDGKGFHKFSEEYEFSKPNDIRALKVMNNAAKNLMAQFPDIMMAYGDSDEYSFLLRRKCSLFERREMKLVSTFASFISVNYLYEWNLEFPEKQIRLERLPTFDARIVVYPTIKHIRDYFSWRQVDCHINNLYNTTFWTLVIKGGMTGREAENKLLGTVSSDKNEMLFKEFGINYNNESEIFKKGTILVREYDYTREGDDLSKRQQQRVEKQRKKASIEEYHLDIIGDTFWNERPWLLE
What is the function of this protein?
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
What are the official names of this protein?
tRNA(His) guanylyltransferase, tRNA-histidine guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(His) guanylyltransferase family.
Protein: APGM_THEMA
Sequence: MFDKQEFVSKLVTEEKAKIVLLVMDGLGDIPVNGKTPLQAANTPNLDNLAKESDLGQTIPVLPGITPGSGPGHLSLFGYDPIKYQIGRGILEALGIGVEVGEKDVVARANFATWDGKVVLDRRAGRPATEESAKVVQLLSEKIKKIEDVEITFYPGKEHRFVVKFTGEGLGDKVTDADPQKEGHPMVWAEGLDEPSKKTARIVNELIKKIAEVLKDNPKINFALIRGFSKYPDLPKFPQVYKMKAGAIATYPMYRGLAKLVGMEIIETGQTVADEIKTLKEKWNDYDFFYVHVKKTDSYGEDGKFEEKVKVIEEVDAIIPEIVSLNPDVLVITGDHSTPVPLKAHSWHPVPLLIWSKYTRRGLSQAFNEFECARGTLGTIHASDVMTLALAYAGKLEKFGA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, aPGAM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Protein: TRPD_CLOB8
Sequence: MIINDAIKKLALREELTEDEVRGVINQIMKGEATSSQIGGFLVGLRVNGETPRQILGAVKAIRDNGVKVEIENTEHLIDTCGTGGDGSKTFNISTAVAIVAASGGAKVAKHGNRAVSSKSGCADVLVELGINIDFDEIQSKKIIEENGMAFLFAPKYNGAMKNVSKERKELGIRTIFNLLGPLANPAPITGQLMGVYDGALLKDIGEVLLNLGLKRAMIVHGDDGLDEITITTSTSICEVKDGKIKNYKLDPEKLGFKKATLDDIKGGEAKENAEIIIKILKGERGPKRDIVVLNSGAALYVANLVDSIEDGIKKASELIDSRAAYKKYEELSSLQVIV
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: SYA_KORVE
Sequence: MTGRCLIKYSFTPMMTGSQVRRRFLDFFISKGHKEVHSSSLVPANDPTLLFTNAGMNQFKDVFLGVEKRDYNRATTSQKCVRAGGKHNDLENVGFTNRHHTFFEMLGNFSFGDYFKKDAIAYAWELVTSPDWYGMQQDKLYATIFKGENGVPRDDEAYQLWLDVGVPKERVFEMGMKDNFWAMGDTGPCGPCSELHYDMGVASSDKKNPECAAGECKFPCECGRYVEIWNLVFMQFDRDASGTLNPLPKPSIDTGAGLERVTAVMQGVVSNYDTDLFTPLIKRAAELTDVDEKREEAKESQSKSAASLRVIADHSRAATFLISDGVIPANEGRGYVLRKIIRRGIRHGRLLGQNKPFLHDMVYAVRDLMQDAYPELKETADRVAKTVLAEETRFANTLDIGLKKLDEDLASLAETTRELGRLSWEEPKPVEFALKEVARHVFVVAQMLSPGMTFDTPGHGFLLRRGIYRAWMDLKAVGLDRVVRLSEIAEALSEGETGRVQSVAKNLAHTKQILDAEQERLQSASSQLEFELDAMEAEKKLAENPEMLAEQVREVFGPALEEKVINELRGKLQSRPVYSGDKAFKLYDTFGLPLDFMVDAARDQGIEFDQAGFDAAMESQRETARASWKGGSKLSASPIYRELAEELGTKPYPGQLAGGHPMITPQSIFVGYTSTEFKGATVLAIISNGASVAQLAPGDVAEMVLDYTPFYSESGGQIGDTGWLYDSTGNTVVAEVETVQSPVQGVRAHKVTARQNIAVGDKLNAVVNADVRRATMRNHTGTHLLHAALREVLGKHVKQAGSLVDPAKLRFDFSHFTGVADEELQDIEDIVNKEVLKNDRVEVIENVPIDVAVNEYKAMALFGEKYGDRVRVIKIGDFSTELCGGTHTLATGEIGLIKVLHEGSVSSGVRRLEAVTGENSVRHFRKDHELEGVVSTIVRPSEGLSPAQALKFELDRREEEIKKLRKELEQSRMKSASSAVSSATESAREVKGIKVLATRADNIDRNQMRTLIDNLRSKLGSGVIVLGSVQDGKVALIVGVTKDLTSKIQAGKIIAQVAKHVGGSGGGRPDMAEAGGKDPAALDGALNATYGIVDSLLS
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VRAC_STAAC
Sequence: MQHYLLDSNQRLNVSFSKDSVAAYYQCFNQPYRKEVPPLMCASLWPKFDLFKKYANSELILTKSAINQTQKIEVDTIYVGHLEDIECRQTRNITRYTMALTLTKNDQHVITVTQTFIKAMK
What are the official names of this protein?
Protein VraC.
Protein: SEPF_STAAB
Sequence: MSHLALKDLFSGFFVIDDEEEVEVPDKQQQVNEAPAKEQSQQTTKQNAIKSVPQKSASRYTTTSEERNNRMSNYSKNNSRNVVTMNNATPNNASQESSKMCLFEPRVFSDTQDIADELKNRRATLVNLQRIDKVSAKRIIDFLSGTVYAIGGDIQRVGTDIFLCTPDNVEVAGSITDHIENMEHSFD
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: CSY2_PECAS
Sequence: MSTLIILRRIQVENANAIAGLTYGFPAITHFLGFTHALSRKLQASHGLTLEGCGVVSHQHQLHAYGSSWERSFALTRNPLTKEAKTAAFNEEGRMHMTVSLLIRCDGQIPADTTALCEHLKQQAQCQRLAGGTVIDIERVTVQSLPVDEAETRGVMRRLLPGFVLRDRTSLLHRHFQTLQQAKPQAEMIDAWLDFAALKMQAERDPSDETVQWKYLPKPGDGGFLTPLMIGYRAISPLYAPGEVDKTRDPHTPFCFAEAAYGIGEWQGAHRISDISQILWEYDYQNGDYHCRQVADTHSVAEDTSYEFDY
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
What are the official names of this protein?
CRISPR-associated protein Csy2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csy2 family.
Protein: MF14C_HUMAN
Sequence: MSVEPPPELEEKAASEPEAGAMPEKRAGAQAAGSTWLQGFGPPSVYHAAIVIFLEFFAWGLLTTPMLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPCRVWWRAPVVPATCGRRMA
What are the official names of this protein?
Major facilitator superfamily domain-containing 14C pseudogene, Hippocampus abundant transcript-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GRPE_PARMW
Sequence: MSGEASTPAQDPSVEPLDAAPVAAEPEVMSTETPAEGSLTDPAERLQQLEHELQTLKQEHETLQSQYMRIAADFDNFRKRQSRDQEDIRQQLVCSTLSEILPVVDNFERARQQLNPESEEAQALHRSYQGLYKQLVDVLKQQGVARMEVVGQLFDPTLHEAVLREESTEQPEDVVIEELQRGYHLNGKVLRHALVKVSMGPGPSADAEGAASAEAEDS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 6PGL_BACSU
Sequence: MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPTYVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQFVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYVVAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIALEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQYSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPSTVSVPYPVCVKFLHQV
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: YVYG_BACSU
Sequence: MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILTKEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVLGRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA
What is the function of this protein?
May be involved in the assembly, structure, or function of the flagellum.  May polymerize to form a filamentous structure that is part of the flagellum.
What are the official names of this protein?
Uncharacterized protein YvyG.
Protein: BIOB_ACET2
Sequence: MDFLTLMENKLDEGRMITFEEAVELAKGKIEDEKLFLLADKLCKKNMGRRVDLCSIINAKSGGCSENCKFCAQSGHYDTGVKIYPLLDVDDVLKAAKENEKEGVHRFSLVTSGKSVSDEEFEKILGIYSVLRKETNLKLCASLGSLSYERAVRLKEAGVSMYHHNIETCREYYPKICDTHTYDDRINTVKNAAKAGLEICCGGIIGMGESMEQRIKMAFEIRELGVKSVPINVLNPIKGTPFENVRSLSPDEILRTIALFRLIMPYAHIRYAGGRMCLGEHQSKGFKAGVSAMLVGNYLTTVGNKISDDLEMIQRMGLEI
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: URE3_ACET2
Sequence: MHLTPRETEKLMLHYAGELARKRKERGLKLNYPEAVALISAELMEAARDGKTVTELMQYGAKILTRDDVMEGVDAMIHEIQIEATFPDGTKLVTVHNPIR
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RA51D_DICDI
Sequence: MEEESISGLEVRFYQTQCLSEDNVIKFENNGYPMIDLILFSDAYQIQRNTSIPIETVTLIQRNLQRLFSSVPINGYQHYLDVKEFKTHYSSGIKLLDQLLGGNGFTSGEIYELVGNTSCGKTQISMCCSLNLSQQYNSNIIYIDSSNSFSPPRLIEIFKSNYLIKQRQKQQQKQQQKQHQKQQENNDKIEQDKILKILDRIKVFNCFDSITLLELLSTIDSTLSIISDEIPTFENQFYKGLKMVVIDSIGTLLAPIIGGKQTQGHYTMMMISRLIKYIADTYQIIFLITNNTVGGNSFDNKAALGEAWSMVPNHQLMINHQYNDDENEERSIYIEKSTRLPVSIIFIINLYWLF
What is the function of this protein?
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
What are the official names of this protein?
Probable DNA repair protein RAD51 homolog 4.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RAD51 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: EIF3M_MOUSE
Sequence: MSVPAFIDISEEDQAAELRAYLKSKGAELSEENSEGGLHVDLAQIIEACDVCLKEDDKDVESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVRYTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWKLTTEKKHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQNLNKVKNSLLSLSDT
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.  The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).  The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.  The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit M, eIF3m, PCI domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit M family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_RHOJR
Sequence: MQSPTAQGTNDGVRPARTWPSVLGTLTDGRDLSVDEAKWAMDEIMSDNATSAQIAAFGVALKMKGETPEELRGLADSMLGHARKVPVDDDVVDIVGTGGDRSNTVNISTMASLVVAASGIRVVKHGNRAASSKSGGADVLEALGVKINLGPDEVARCVREVGIGFCFAPVFHPALRFAGAPRKEIGIPTVFNVLGPLTNPARPRAGLIGCAFPGLISVVAGVLAQRGNSALVVRGDDGLDELTTSTTSTVHIVADGAVTTRQLDPRDIGIARVSLDELRGGDAEVNAAVARRLFAGETGPVRDAVLLNAAAAIAAFRGLGGRTLEDALSDGLSTAAQSIDSGAAATLLARWAELTSGLATSK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: CH60_TERTT
Sequence: MAAKDVKFGDDARQKMLVGVNVLADAVKTTLGPKGRNVVLDKAFGAPTVTKDGVSVAKEIELKDKFENMGAQMVKEVASKASDDAGDGTTTATVLAQAIVNEGLKSVAAGMNPMDLKRGIDKAVAAAVEFVKSSAQPCEDSKSIAQVGTISANSDSHIGDIIAEAMEKVGKEGVITVEEGSGLENELDVVEGMQFDRGYLSPYFITNQDNMSVEHESPFILLVDKKISNIRELLPVLEAVAKAGKPLVIVAEDVEGEALATLVVNNMRGIVKVAACKAPGFGDRRKAMLQDIAILTGGTVISEEVGLDLESATLEHLGQAKRFTMSKENSVIVDGAGSADDIKARVNQIRKQIEETSSEYDAEKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVSLMRAVAAIADLQGENEDQTAGVAIARRAMEAPLRQIVTNAGEEASVVAEKVRGGEGNFGYNAGSGVYGDMLEMGILDPAKVTRTALQAAGSIAGLMITTEAMVADKPEDKAGPAVPDMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG042_MONPV
Sequence: MNPDNTIAVITETIPIGMQFDKVYLTTFNMWREILSNTIKTLDISSFYWSLSDEVGTNFGTVILNEIVQLPKRGVRVRVAVNKSNKPLKDVERLQMAGVEVRYIDITNILGGVLHTKFWISDNTHIYLGSANMDWRSLTQVKELGIAIFNNRNLAADLTQIFEVYWYLGVNNLPYNWKNFYPSYYNTDHPLSINVSGVPHSVFIASAPQQLCTMERTNDLTALLSCIGNASKFVYVSVMNFIPIIYSKAGKILFWPYIEDELRRSAIDRQVSVKLLISCWQRSSFIMRNFLRSIAMLKSKNIDIEVKLFIVPDADPPIPYSRVNHAKYMVTDKTAYIGTSNWTGNYFTDICGASINITPDDGLGLRQQLEDIFIRDWNSKYSYELYDTSPTKRCRLLKNMKQCTNDIYCDEIQPEKELPEYSLE
What is the function of this protein?
DNA nicking enzyme that cleaves extruded cruciform DNA at its tip.  Probably nicks viral hairpins.
What are the official names of this protein?
Virion nicking-joining enzyme, Phospholipase-D-like protein K4.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG042 family.
Protein: LHX1_MOUSE
Sequence: MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEGGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLDHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGASYGNHLSHPPEMNEAAVW
What is the function of this protein?
Potential transcription factor.  May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.
What are the official names of this protein?
LIM/homeobox protein Lhx1, LIM homeobox protein 1, Homeobox protein Lim-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: NPHP3_HUMAN
Sequence: MGTASSLVSPAGGEVIEDTYGAGGGEACEIPVEVKPKARLLRNSFRRGAGAAAGAGPGSLPRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRKEYEIFRVSKNQELLSMGRREAKLDTENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKENEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWTGGALGSEPSIGSMIQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDIAVASLLQVTPLFSHSLWSNTVRCYLIYTDETQPEMDLFLKDYSPKLKRMCETMGYFFHAVYFPIDVENQYLTVRKWEIEKSSLVILFIHLTLPSLLLEDCEEAFLKNPEGKPRLIFHRLEDGKVSSDSVQQLIDQVSNLNKTSKAKIIDHSGDPAEGVYKTYICVEKIIKQDILGFENTDLETKDLGSEDSIPEEDDFGDVLWDIHDEQEQMETFQQASNSAHELGFEKYYQRLNDLVAAPAPIPPLLVSGGPGSGKSLLLSKWIQLQQKNSPNTLILSHFVGRPMSTSSESSLIIKRLTLKLMQHSWSVSALTLDPAKLLEEFPRWLEKLSARHQGSIIIVIDSIDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPPAWRLWPTLHLDPLSPKDAKSIIIAECHSVDIKLSKEQEKKLERHCRSATTCNALYVTLFGKMIARAGRAGNLDKILHQCFQCQDTLSLYRLVLHSIRESMANDVDKELMKQILCLVNVSHNGVSESELMELYPEMSWTFLTSLIHSLYKMCLLTYGCGLLRFQHLQAWETVRLEYLEGPTVTSSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSKQKLHDCLLNLFVSQNLYKRGHFAELLSYWQFVGKDKSAMATEYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSRHSSSGDTFSLKTAHSPNVFLQQGQR
What is the function of this protein?
Required for normal ciliary development and function.  Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity.  Probably acts as a molecular switch between different Wnt signaling pathways.  Required for proper convergent extension cell movements.
What are the official names of this protein?
Nephrocystin-3.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus.
Protein: COAX_HYDCU
Sequence: MLIFFELGNSQLKAATILKGNYQFLGSVRHDAILSGEFIESFNLNEQNPTAVYVSSVAPSQLNAALTEVIQQHFKLYPTFLATQPSCCGIECGYEKFDQFGVDRWMAILGACSGSNKPTFIVDAGTALTVDAVIDKKHIGGFIVPGLGLMRDSLLKNTALSEQSLVLQSVQDGLLAKDTAGGVMGGTLYMLGSYLNSLLVDLELETGRKFDCIGTGGDFLSLKPVLDKPYNYVEDLTLRGMKEVIESL
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LHB_AFIMA
Sequence: AEIDRPVSLSGLTEGEAREFHGVFMTSFMVFIAVAIVAHILAWMWRPWIPGPEGYA
What is the function of this protein?
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
What are the official names of this protein?
Light-harvesting protein B-880 beta chain, Antenna pigment protein beta chain.
What is the protein family that this protein belongs to?
Belongs to the antenna complex beta subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: ACUK_ASPCL
Sequence: MNVEAKESSVAPAGDHGGAVQDPADVRDRLELLKNKANGETNGATPNGTKSTNAKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPDGALMPGVGGNFYNHPMRHNMPLSSNGANAVNATSQQNSGASFYPTPQSNPYNVYQESTLSQNSFPSQSPVSPTFNMKNTATARSNSLSSSVNQPQSNPAASGPPSQSQNPFAGPFFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPSESATQRGSIGRSGSAQFATTPITGNPGFGESPGNQQPFMFGNDPLLNEWPNNHPPGQGHMNVGGVYPQNSMMAGHLSKADAPHAFAIESGPASFSSPSATTSPHVNGGYDENALSNAVAHKPNGLPTNGQRPAITTPRLKHQSLQLGVKRRHRNPSTVYESVKEPYAYTNRFHNLTAFIQRRFSSQKTLQIAKALASIRPSFIATTKTLNRDDLIFMEKCFQRTLWEYEDFINACGTPTIVCRRTGEIAAVGKEFSILTGWKKDVLLGKEPNLNVNTGGTSIPQSGTSSRGSFTPRISTLEQANPARPQPVFLAELLDDDSVVDFYEDFARLAFGDSRGSVMTTCKLLKYKTKEDMELAQSDDNQRWNNHLRKGGIAGEAGMNQLGFKDGKVECAYCWTVKRDVFDIPMLIVMNYLIPSDGFKSSIPF
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes (By similarity).
What are the official names of this protein?
Transcription activator of gluconeogenesis acuK.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.