PharMolix/UniProtQA huggingface dataset:
Protein: SED5_YEAST
Sequence: MNIKDRTSEFQQSVLSYKKRNKNFREQQRERLQEKESENFANNTTGNGKSVSEFQKKASGIAHEISSTAQLLSKLAVLAKRKPMFNDNPVEIAELSFLIKRKIYAIEQSLVQLSQLKKTDVNGNTSNQSSKQPSAVQHSKNVVNLLNTQMKNISGSFKDVLEERQRLEMANKDRWQKLTTDTGHAPADDQTQSNHAADLTTYNNSNPFMTSLLDESSEKNNNSSNQGELSFPQNDSQLMLMEEGQLSNNVYLQERNRAVETIESTIQEVGNLFQQLASMVQEQGEVIQRIDANVDDIDLNISGAQRELLKYFDRIKSNRWLAAKVFFIIFVFFVIWVLVN
What is the function of this protein?
Required for vesicular transport between the endoplasmic reticulum and the Golgi complex.  Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE).
What are the official names of this protein?
Integral membrane protein SED5.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.
Protein: YEGS_SHIDS
Sequence: MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGGVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDGLVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDNPNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTX3D_ACTPL
Sequence: MKLWILGLGEFFQRYRNIWREIWKIRKQLDTPARQKDENEFLPRHLELIETPISKKPRLIAYLIMLFLFLAIVISIISKVEIVASATGKLVFSGHSKEIKPIENALVKDIFVKDGQFVEKGQLLLNLTALGCDADKQKTKVSLGLERLDGYRYKSLLYSIEHNRLPLLDFNQADFDSVQEEDKTGARHLITEQFETWQKQKYQKELAYQRKQAEKQTVLANIRKYESASRIEKEKLSDLKKLYDVKSISKHELLAQENRYVEASNELSVYQSHLKEVESDLLKAQEDLKLVTQLFKSDILEKLQQNIQREKQLTLELEKNEQRQLASIIRAPVSGTVQQLKTHTKGGVVTTAETLMVIAPEDDVLEVSALIQNKDVGFVEIGQEAVIKVETFPYTRYGYLYGKVKTITLDAIEHPQLGLVFNSIIEINKKTLTDGDKEIQLGSGMSVIAEIKTGERSVISFLLSPLEESITESLRER
What is the function of this protein?
Involved in the transport of the toxin RTX-III.
What are the official names of this protein?
RTX-III toxin determinant D, APX-IIID, Cytolysin IIID, CLY-IIID, Toxin RTX-III secretion protein D.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: BGLM_ASPFN
Sequence: MHAIAGLTGFLAGVSLSYAAPTQENITSDAYFYGQSPAVYPSPEGTGSGAWASAYEKAKAFVANLTPEEKVNLTAGTDADNGCSGNIPAIPRLNFPGLCVSDAGNGLRSTDHVNAWSSGIHTGASWNKDLAQKRGLHMGSEYHKKGVNVLLGPVVGPLGRIAEGGRNWEGFSVDPYHSGLLVYETIRGIQAAGVGTSTKHYIANEQETNRNPESTDGIDVAAVSSNIDDKTMHELYLWPFQDVVRAGSVSIMCSYQRINNSYGCQNSKTLNGLLKTELGFQGYVMTDWGAQHGGIASSNAGLDMVMPSSTLWNSNLTDAIANGTMEASRLDDMATRIIASWYQMNQDAGFPSPGIGMPADVYAPHQAIIGKSSDSRKVLLQSAIEGHVLVKNKNNTLPLKSPEMISVFGYDAKGPDSLGFALEWLSYSPAIQPNHTLIVGGGSGGNSPAYISAPLDALQQQVIEDGSSILWNISAQDPEVDPNTDACLVFINSYATEGYDRAGLVDEGSDELVTNVASKCSNTIVTIHNAGIRLVNNWIDHENVTAVIFAHLPGQDSGRALVELLYGRSNPSGKLPYTVAKNADDYGALLHPKLPEGQYGLFPQDDFSEGVYIDYRAFDKQGIEPQFEFGFGLSYTTFDYSGLNIGQVSDNSTSRYPPSAAIQEGGNPHLWDVILRVSVDITNSGPVAGDEVAQLYVGIPNGPVRQLRGFEKVNIPVGQTVTVEFALGRRDLSTWDVVAQEWLLQSGTYQVYVGRSSRDLPLQGEFTI
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase M, Beta-D-glucoside glucohydrolase M, Cellobiase M, Gentiobiase M.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLH1_ARATH
Sequence: MAAIEDSPTFSSVVTPAAFEIGSLPTTEIPVDPVENDSTAPPKPVRITCPTVAGTYPVVLFFHGFYLRNYFYSDVLNHIASHGYILVAPQLCKLLPPGGQVEVDDAGSVINWASENLKAHLPTSVNANGKYTSLVGHSRGGKTAFAVALGHAATLDPSITFSALIGIDPVAGTNKYIRTDPHILTYKPESFELDIPVAVVGTGLGPKWNNVMPPCAPTDLNHEEFYKECKATKAHFVAADYGHMDMLDDDLPGFVGFMAGCMCKNGQRKKSEMRSFVGGIVVAFLKYSLWGEKAEIRLIVKDPSVSPAKLDPSPELEEASGIFV
What is the function of this protein?
Catalyzes the hydrolysis of ester bond in chlorophyll to yield chlorophyllide and phytol (PubMed:10611389, PubMed:11950974).  Shows a preferential activity toward chlorophyll a (PubMed:11950974).  Does not seem to be required for chlorophyll degradation during senescence (PubMed:17996203, PubMed:18349515, PubMed:31779896).  May modulate the balance between different plant defense pathways (PubMed:15598807).
What are the official names of this protein?
Chlorophyllase-1, AtCLH1, Chlorophyll-chlorophyllido hydrolase 1, Chlase 1, Coronatine-induced protein 1, CORI1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MDH_HALHL
Sequence: MKAPVRVAVTGAAGQIGYSLLFRIAAGEMLGKDQPVTLQLLEIPQAQEALQGTVMELEDCAFPLVDGIIATDSAEEAFRDADYVLLVGAKPRGPGMERKDLLEANAAIFSAQGQALNAVAKRDVKVLAVGNPANTNALITQRNAPDLDPRNFTAMTRLDHNRALAQLSNKVGCHSTEIRGLAVWGNHSATQYPDISHCTIQGRPAADQVEHAWVKDTFIPTVQQRGAAIIKARGASSAASAASAAIDHMRDWALGTPEGEWTSMAVPSDGSYGIEAGLIYSFPVTCRGGDYKIVSGLSVDDFSRARMDQTAAELAEERDAVAHLLP
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: RPPH_XYLFT
Sequence: MIDPDGYRPNVGIVLIRRDGQVFWGRRVRRDGWQFPQGGMHSDETPVEAMYRELNEETGLLPEHVQLVGATPGWLRYRLPSQAVRCNRSQMCIGQKQVWFLLQLIGDESHVQLDQSENPEFDHWRWVSFWYPIEHVVMFKRSVYARALCQLASLAQQVVGLEVGTMPQYVQDICLLNVGYKHLPNWVSRY
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: TRMD_VIBCM
Sequence: MWVGIVSLFPEMFRSVTDFGVTGQAVKKGLLSVEAWNPRDFAHDKRRTVDDKPYGGGPGMLMMVQPLRDAIHAAKQASPGKTKVIYLSPQGRKLDQQGVEELAQNQNLILICGRYEGVDERIIESEVDEEWSIGDFVMTGGELPAMTLIDSVSRFIPGVLGDFASAEEDSFANGLLDCPHYTRPEVLDGKEVPAVLKSGNHEDIRRWRLKQSLGRTWLRRPELLENLALTDEQEQLLTEYIKETRHQ
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_CLOPE
Sequence: MFELNNFDALQIGLASPEQIREWSRGEVKKPETINYRTLKPERDGLFCERIFGPIKDWECHCGKYKRVRYKGIVCDRCGVEVTKSKVRRERMAHIELAAPVSHIWYFKGIPSRMGLILDMSPRALEKVLYFASYIVIDPKETSLLKKQLLNEKEYREACDKYGEESFVAGMGAEAIKTLLSEIDLERTAAELKEELKQSTGQKKVRIIRRLEVVESFKSSGNKPEWMVVDVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKKLLDLGAPDIIVRNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKMYQCGLPKEMALELFKPFVMKKLVEDGVAHNIKSAKRMVERVMPQVWDVLEEVIADHPVLLNRAPTLHRLGIQAFQPVLVEGRAIKLHPLVCTAYNADFDGDQMAVHVPLSVEAQAEARFLMLAAGNIMKPSDGRPVCVPTQDMVLGSYYLTMDKDGAKGEGKYFASFDEVIMAYQLKEVDIHAKINVKVTKEIDGELKSGIIKTTPGFIIFNECIPQDLGFVNRENPEEMFNLEIDFLITKKSLGKIIDKCYLKHGPTKTSIMLDNIKATGYHYSSIGAVTVAASDMIVPQKKYELLKEADETVDKIEKMYRRGLISEDERYERVIEKWTETTEEVADTLMNSLDKFNPIFMMADSGARGSKSQIKQLAGMRGLMASPSGKIIELPIRASFREGLDVLEYFISTHGARKGNADTALKTADSGYLTRRLVDVSQDVIVREHDCGTQNGIYVEEIKEGSEVVEQLAERLTGRYTAEDVFHPETGELLAAKDTYMDPILAEKIADTGIQKVKIRSVFTCDSKVGVCTKCYGMNMATSYKINIGEAVGIVAAQSIGEPGTQLTMRTFHTGGVAGADITQGLPRVEELFEARKPKGLAIVSEVAGTVRIEETKKKRTVYVVTDSGEEYSYDIPFGSRLKVKDGIAIGAGDEITEGSVNPHDIMSIKGVDGAREYLLSEVQKVYRLQGVDINDKHLEVVVRQMTRKIKVTEQGDTNLLPGVMIDMFDFRAENERVESFGGEKAQGDIVLLGITKAALATDSFLSAASFQETTRVLTDAAIKGKIDPLVGLKENVIIGKLIPAGTGMMKYRSLKLNTENSNQETETIIEIEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: G1PDH_BACVZ
Sequence: MKRSPEDIQSEFDKEGASRSPIQIEDIVIGANAKEELLRFLQKKCWNHPVIVCDRNTYEAAGRLLADELRAGGIKASKVIIPEHEAGAAAADERTLVYTLINLAEETDVIIAAGAGTIHDITRFAAYQRGLPFISFPTAPSVDGFTSAGAPLILNGIKTTIQTKAPIALFADTNVLKEAPRSMTAAGFGDMLGKITSLADWEISRRLAGEPYSEAGAKLVKDALWQCIDHRAAIAMGTEAGIQILMEALIVSGLVMLALDHSRPASGGEHHISHWIEMEMLKAKQPPILHGAKVGCACAVLSDTYKELACHEKLAELPPHFREAIQSAYEGLPDGKTIAGWLASAGGPACFDEIGVKQDLVSDALKHAHTLRDRYTGLTIINENAALFAHHLHQ
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG157_VACCW
Sequence: MEDLNEANFSHLLINLSNNKDIDAQYASTLSVVHELLSAINFKIFNINKKSKKNSKSIEQHPVVHHAASAGREFNRR
What is the function of this protein?
Required for the association between the dense viroplasm and the viral membranes to form the mature virion (MV).
What are the official names of this protein?
Protein OPG157.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG157 family.
Protein: ODAM_CANLF
Sequence: MKTIILLGLLGATMSAPLIPQRLMSASNSNELLLNLNNAQLQPLPFQGPFNSWIPPFSGILQQQQQAQIPGLSQFSLSALDRFAGLFPNQTPFPGRVSFAQGTQVGQQDPSQPQTPPQTQQSPNHVMPYVFSFKMPQEQAQMLQYYPVYMLLPWEQSQQTAPQSPPQTGQQQFEEQMPFYTQFGYVPVQVEPVMPGGQQQLALDPVLGTAPETVVMPAGVIPYLRKEVINFKHANGGIFVPSTSQTPSTTNYFAPAIDPTITPELMEKKAKTDYLKEP
What is the function of this protein?
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth.  May be incorporated in the enamel matrix at the end of mineralization process.  Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK.  Plays a role in attachment of the junctional epithelium to the tooth surface.
What are the official names of this protein?
Odontogenic ameloblast-associated protein, Apin.
What is the protein family that this protein belongs to?
Belongs to the ODAM family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Nucleus.
Protein: NHR2_CAEEL
Sequence: MVPMNPELMHYPNQPHMMPGYPMINAYQQSYLQNPAQWTPEMLLCMQMQMQQMVPGTATNSTYMPPQSKNTVTPNATSPLSQISDRDSGNDTISPPLTSQNSATTPNYHNQPQMQLTPLQQAKPEKEEISPYAINNILSSTQSSPDNGNEADDKENSSVRRNTFPASSASTKKPRGTPYDRTNTPMTVVPQMPQFAPDFSNYNLTMNAWSEFFKKDRCMVCGDNSTGYHYGVQSCEGCKGFFRRSVHKNIAYVCTKGENCTFSYENCAANRGVRTRCQACRFAKCLAVGMNRDNVRVNKETDKDVKPSVASPNFEMTSQVKELTAAFVANMPCSTHLTSGTHAIGAIKKFIESVPALSSLLPKDEKALEMSIQKVMSGILAIRAAFTFDPITFYSCENPVNLLRGGIRNTVFNDCEVALLSGIHILQIVNGGVAEIFTSYCQGLRHQLSQTHLQEIGLCDRLLMRLGPYLNQ
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL1_THEMA
Sequence: MPKHSKRYLEARKLVDRTKYYDLDEAIELVKKTATAKFDETIELHIQTGIDYRKPEQHIRGTIVLPHGTGKEVKVLVFAKGEKAKEALEAGADYVGAEDLVEKIEKEGFLDFDVAIATPDMMRIIGRLGKILGPRGLMPSPKSGTVTQEVAEAVKEFKKGRIEVRTDKTGNIHIPVGKRSFDNEKLKENIIAAIKQIMQMKPAGVKGQFIKKVVLASTMGPGIKLNLQSLLKE
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PDE11_HUMAN
Sequence: MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
What is the function of this protein?
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539).  Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148).
What are the official names of this protein?
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PGRP2_HUMAN
Sequence: MAQGVLWILLGLLLWSDPGTASLPLLMDSVIQALAELEQKVPAAKTRHTASAWLMSAPNSGPHNRLYHFLLGAWSLNATELDPCPLSPELLGLTKEVARHDVREGKEYGVVLAPDGSTVAVEPLLAGLEAGLQGRRVINLPLDSMAAPWETGDTFPDVVAIAPDVRATSSPGLRDGSPDVTTADIGANTPDATKGCPDVQASLPDAKAKSPPTMVDSLLAVTLAGNLGLTFLRGSQTQSHPDLGTEGCWDQLSAPRTFTLLDPKASLLTMAFLNGALDGVILGDYLSRTPEPRPSLSHLLSQYYGAGVARDPGFRSNFRRQNGAALTSASILAQQVWGTLVLLQRLEPVHLQLQCMSQEQLAQVAANATKEFTEAFLGCPAIHPRCRWGAAPYRGRPKLLQLPLGFLYVHHTYVPAPPCTDFTRCAANMRSMQRYHQDTQGWGDIGYSFVVGSDGYVYEGRGWHWVGAHTLGHNSRGFGVAIVGNYTAALPTEAALRTVRDTLPSCAVRAGLLRPDYALLGHRQLVRTDCPGDALFDLLRTWPHFTATVKPRPARSVSKRSRREPPPRTLPATDLQ
What is the function of this protein?
May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments.  Has no direct bacteriolytic activity.
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase, Peptidoglycan recognition protein 2, Peptidoglycan recognition protein long, PGRP-L.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
What are the subcellular locations of this protein?
Secreted. Membrane.
Protein: NCPP_ECOL6
Sequence: MHQVVCATTNPAKIQAILQAFHEIFGEGSCHIASVAVESGVPEQPFGSEETRAGARNRVANARRLLPEADFWVAIEAGIDGDSTFSWVVIENTSQRGEARSATLPLPAVILEKVREGEALGPVMSRYTGIDEIGRKEGAIGVFTAGKLTRTSVYHQAVILALSPFHNAVYQPLQA
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: Y091_MYCPN
Sequence: MGGWMLCAPPIYTPHTNSWTERWDRTSWWRWSAQRWSGWSFKIVRANKALRVMAKTKMPLVLIPPSPNKPYSKLAINQELHLIPPKKTSPATSSSLKPRPGPRGCLNARLSWRCPTLSRKVRVPTIKVPMVRAPSTPP
What are the official names of this protein?
Uncharacterized protein MPN_091.
What is the protein family that this protein belongs to?
To M.pneumoniae MPN_413 and MPN_463.
Protein: RLMH_GEOSM
Sequence: MRLKLLWVGKTQESWVRTGIEEYAGRIRRYAPLEILEAREEKGAQAAAMRERECERLAKLIPKGGRLVLLDERGEAMTSPELASFLSKNRDQGTQDLVFAIGGAYGFTDAFRSQAFKSISLSRMTLTHQMVRVFLLEQIYRGFTIINGEPYHHE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_BACCQ
Sequence: MTTQVVNVIGAGLAGSEAAYQIAKRGVQVRLYEMRPVRQTPAHHTDKFAELVCSNSLRANTLTNAVGVIKEEMRLMDSVIIRAADECSVPAGGALAVDRHEFAAKVTEYVKNHPNVTVVNEEITKIPEGPTVIATGPLTSPDLSAQLKELTGEDYFYFYDAAAPIVEKDSIDMNKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALIAAETVPLKEFEKEIFFEGCMPVEVMASRGRQTLVFGPMKPVGLEDPKTGKTPYAVVQLRQDDAAGTLYNIVGFQTHLKWGPQKEVLQLIPGLENAEIVRYGVMHRNTFINSPNLLRPTYQYKQRDDLFFAGQMTGVEGYVESAASGLLAGINAARLVKGEEPVVLPPVTAMGSMANYITATNAKNFQPMNANFGLFAPLEKKIKKKAERNEAYATRALETIRNFVNI
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA_DESAH
Sequence: MTDNRPVIGITMGDPVGIGPEIIVSALDDPFVYTVCRPLVLGDEGVMERAIDLKSARMDVHTTDTPAGGKYCHGTMDIVPLSRLDAATLLAGHPTPGTGKAMIDYITTGVDLAMDGKIQAIATCPITKTAMKLAGSKFHGHTELIADRTHTPRVAMMMAGDRLRVVLVTIHIPLCEVSARLNQAEILATISLTSETLKTKFGIPEPRIAVAGLNPHGGEDGMFGSEELEIIAPAVEQARSKGITVSGPFPPDTLFFNAANHKFDAVVCMYHDQGLIPFKMIHFSDGVNTTLGLPIIRTSVDHGTAYDIAWRGTADPSSLIAAIKMAALQATITGANRINR
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NNRE_DROAN
Sequence: MVKYLSQSEAINVDQELFNDYKFSVDQLMELAGLSCAHAISKCFPTDKYGRVLICCGPGNNGGDGLVCARHLALMGYTPTIYYPKPTAKPLYENLSHQCKLMEICRVEDCPAINEAASNFDLIVDALFGFSFKPPVRAEFVAIVELMQQTTLPIASVDIPSGWDVEKGKVNDSDLEPDLLISLTAPKICARNFKGRYHYLGGRFVPPALQRKYDLNLPTYPGNELCLKL
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
Protein: RL7_PEDPA
Sequence: MALDKDQFIEDLKGASITDLNDLVKAIEDEFGVSAAAPVAAAGAAGGAAEAKTSFNVELTSGGSAKIKVIKAVREITGAGLKDAKDMVDNAPSVIKEDVSEDEANELKAKLEEAGATVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: Y1498_PSYCK
Sequence: MSELKTVGLFALTALAEIAGCYLPYLWLREGKSVWLLIPGALSLIAFVWLLSLHPTAAGRVYAAYGGVYISMVILWLWTVNGIRPTTWDIVGSAIALLGMAIIMFAPRSA
What are the official names of this protein?
UPF0060 membrane protein Pcryo_1498.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PG036_VACCC
Sequence: MTSSAMDNNEPKVLEMVYDATILPEGSSMDPNIMDCINRHINMCIQRTYSSSIIAILNRFLTMNKDELNNTQCHIIKEFMTYEQMAIDHYGEYVNAILYQIRKRPNQHHTIDLFKKIKRTPYDTFKVDPVEFVKKVIGFVSILNKYKPVYSYVLYENVLYDEFKCFINYVETKYF
What is the function of this protein?
Plays a role in the inhibition of host innate immune response.  Within the host nucleus, inhibits activation of interferon-beta promoter by inhibiting IRF3 activation.
What are the official names of this protein?
Protein OPG036, Protein N2.
What is the protein family that this protein belongs to?
Belongs to the poxviridae OPG036 family.
Protein: H2AV3_DICDI
Sequence: MKRNNNLIIPLLKIKKLLKRKGCKRIQNSALVFFSKVLQYLIEELLEISMNVSILNKTKKYRIKPKDISWSIQSDPEFNLLFRNIIIPSSGRISNKLNRIIQRSFKFKSFKFDDYEKSDYSSKTF
What is the function of this protein?
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
What are the official names of this protein?
Histone H2A.v3.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ING3_CHICK
Sequence: MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVNEFFMNAKKNKPEWREEQMTSIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDTPSQPVNNHHAHSHTPVEKRKHNPSSHHGATDHVPEKKFKSEALLSTLTSDASKENTPGRRNNNSSSSSNNAYNTNSSQPLASYNLGSLSSGSGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNNDFQLGREFSLSRDSTGYSSSALASTLTQTLSSSSTDSRSGRKSKNNNKSSSQQSSSSSSSSSLSSCSSSSALAQELSQQTAVIPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
What is the function of this protein?
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity).  NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).
What are the official names of this protein?
Inhibitor of growth protein 3.
What is the protein family that this protein belongs to?
Belongs to the ING family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FAP2_SCHPO
Sequence: MSRTIVIVGCGVFGLSTAVELAKNHSFDNIIAIDAEPVPSSMSAANDINKIVRPEYADLKYMKLALEAMEKWRNDPELSSVYFECGRLSTISKDPYRARFDEVAQRNLRKLLGDSALINLSSSEEIRKKYPSLFSNSPLRSDMQAVVNEHAGYANSAASLKLLELKARELGVEFVFGKAGKFKKFVVNHSETDIDKNDNHVSVQTEDGTIYHADTILLAVGAYLNAYLNTSHRVCAKGLPVAHIQLTDEEFKTYKNMPIIFDPDCAYAFPPYPVTKLIKLASTGYEYVCNVETDYDENSKVVSIPHSGPSKSSLPKYAIIQMRRFLDTFLPDLADRSLINTKMCWISDTEDANFLIDKVPQFDNVFVANGDSGHAFKFLPNIGRYIAQRILGDLSEEWKDAWRWREDDKASELKWRCVRSLIDYKDAEFTYDK
What are the official names of this protein?
L-saccharopine oxidase.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Nucleus.