PharMolix/UniProtQA huggingface dataset:
Protein: UPPS_XANOR
Sequence: MASPAMHPVPPVADVPRHIAIIMDGNGRWAQRRRRPRVIGHRAGARAVNRTIDFCLEKGVSALTLFAFSSENWGRPQDEVDALMKLFLHALDREVGELQRRGVQVRFIGDRSRFAAPLRDRMAGAERSTAANARLVLSIAASYGGRQDIATAARALAEDVAAGRLQPEQIDEALLSSRVALADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVMQQALDDYAGRERRFGLTSAQIADKATETSSA
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP).  UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
What are the official names of this protein?
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), Ditrans,polycis-undecaprenylcistransferase, Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: TA2R9_PAPHA
Sequence: MPSTIEAIYIILIAGELTIGIWGNGFIVLVNCIDWLKRRDVSLIDIILISLAISRICLLCVISLDGFFILLFPGTYDINVLESIMDAVWTFANNSSLWFTSCLSIFYLLKIANISHPFFFWLKLKINKVILAILLGSFLISLIISFPINGXWYHLFKVSHEENITWAFKVSTIPGAFKQLTLNLGAMVPFMLCLISFFLLLFSLVRHTKQIQLHATGLRDPSTEAHMRAIKAVIIFLLLLIVYYPVFLVMTSSTLIPQGKLVLMIGDIVTVIFPSSHSFILIMGNSKLREAFLKMLRFVKGFLRRRKPFGP
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 9, T2R9.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SLAC1_ARATH
Sequence: MERKQSNAHSTFADINEVEDEAEQELQQQENNNNKRFSGNRGPNRGKQRPFRGFSRQVSLETGFSVLNRESRERDDKKSLPRSGRSFGGFESGGIINGGDGRKTDFSMFRTKSTLSKQKSLLPSIIRERDIENSLRTEDGETKDDSINENVSAGRYFAALRGPELDEVKDNEDILLPKEEQWPFLLRFPIGCFGICLGLSSQAVLWLALAKSPATNFLHITPLINLVVWLFSLVVLVSVSFTYILKCIFYFEAVKREYFHPVRVNFFFAPWVVCMFLAISVPPMFSPNRKYLHPAIWCVFMGPYFFLELKIYGQWLSGGKRRLCKVANPSSHLSVVGNFVGAILASKVGWDEVAKFLWAVGFAHYLVVFVTLYQRLPTSEALPKELHPVYSMFIAAPSAASIAWNTIYGQFDGCSRTCFFIALFLYISLVARINFFTGFKFSVAWWSYTFPMTTASVATIKYAEAVPGYPSRALALTLSFISTAMVCVLFVSTLLHAFVWQTLFPNDLAIAITKRKLTREKKPFKRAYDLKRWTKQALAKKISAEKDFEAEEESHH
What is the function of this protein?
Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis.  Cl(-) efflux through SLAC1 causes membrane depolarization, which activates outward-rectifying K1 channels, leading to KCl and water efflux to reduce turgor further and cause stomatal closure, that reduces water loss and promotes leaf turgor.  Essential for stomatal closure in response to CO(2), abscisic acid (ABA), ozone O(3), light/dark transitions, humidity change, calcium ions, hydrogen peroxide H(2)O(2), reactive oxygen species (ROS), and nitric oxide.  Binds to the highly selective inward-rectifying potassium channels KAT1 and AKT2, and inhibits their activities.  Functions as an essential negative regulator of inward potassium channels in guard cells.  Essential for the efficient stomatal closure and opening in guard cells (PubMed:27002025).  Involved in the local and/or systemic stomatal responses (e. g.  stomatal closure) to light stress (PubMed:29463779).
What are the official names of this protein?
Guard cell S-type anion channel SLAC1, Protein CARBON DIOXIDE INSENSITIVE 3, Protein OZONE-SENSITIVE 1, Protein RADICAL-INDUCED CELL DEATH 3, Protein SLOW ANION CHANNEL-ASSOCIATED 1.
What is the protein family that this protein belongs to?
Belongs to the SLAC1 S-type anion channel family.
Protein: TRPD_HALHL
Sequence: MDLTAALRRITENQDLSPDEMTAVFRTIMTGGATPAQIGGFLIGMRLKGETVQEMAAAASVMRELAERVDVGDDFHRLVDTCGTGGDARGTLNVSTAAAFVTAAGGIPVAKHGNRSVSGRSGSADLLEACGATLELSSEAVAECIRRVNVGFLFAPLHHSAMKHAVGPRKELGVRTLFNLVGPLSNPAGARRQLLGVFGQEWVRPVAEVLQALGSDHVLVVHAEDGLDEISIAAPTRIAELRNGQIEEYTVTPEDLGLRSAPLNEVTISGTKDSLAMIRAAFSGERIAAMELIAANAGAALYVGGEAPDLRRGVERARELMTSGAAAQTLERFVATTKELAQ
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: FUMC_HAEIN
Sequence: MAFRIEKDTMGEVQVLADKYWAAQTERSRNNFKIGPAASMPHEIIEAFGYLKKAAAFANHDLGVLPLEKRDLIALACDEILANKLDDQFPLVIWQTGSGTQSNMNVNEVVANRAHVLNGGKLGEKSIIHPNDDVNKSQSSNDTFPTAMHIAAYKKVVEHTIPCVERLQKTFAAKSEAFKNVVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLKALKNTLPHLSQLALGGTAVGTGLNTPKGYDLKVVDYIAKFTALPFVTADNKFEALAAHDAIVETHGALRQLAMSLFKIANDIRLLASGPRSGIGEILIPENEPGSSIMPGKVNPTQCEXMTMVCAQVFGNDTTIAFVGSQGHFQLNVFNPVMIANFLQSAQLLGDACVSFDEHCAVGIEPNYPRIKQQLENSLMLVTALNTHIGYENAAKIAKTAHKNGTTLREEAINLGLVSAEDFDKWVRPEDMVGSLK
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGGU_ECOL5
Sequence: MSAVTVNDDGLVLRLYIQPKASRDSIVGLHGDEVKVAITAPPVDGQANSHLVKFLGKQFRVAKSQVVIEKGELGRHKQIKIINPQQIPPEIAALIN
What are the official names of this protein?
UPF0235 protein YggU.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: RECR_LEUMM
Sequence: MQYPEPIAKLIDSYTKLPGIGPKTATRLAFYTLGMNEEDVQDFSKALISAKTDLTFCSICGNITATDTDPCVICRDQSRDQSTVFVVENSRDVMAMENTRDYHGLYHVLNGVISPSAGTGPEDINLPSLIRRLSEHEEIKEVIVGTNANAEGEATAMYLARLLKPAGIAVTRLAHGLAVGSDIDYADELTLIKAVQGRTKL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: PSTB_JANSC
Sequence: MKDMSMSNPTESAAVTDMKMQARGVDVFYGAGASARSADDMAADKSVTHAIKEVDVDIADKTVTAFIGPSGCGKSTFLRVLNRMNDTIDGCRMTGKVTLEGEDIYDPKVDPVQLRAKVGMVFQKPNPFPKSIFDNVAYGPRIHGLARNKADLSDIVEKSLRRAAIWEEVKDRLDAPGTGLSGGQQQRLCIARAVATSPEVLLMDEPCSALDPIATAQVEELIDELRTRFSVVIVTHSMQQAARVSQKTAFFHLGNLVEFDETDKIFTNPSDPRTESYITGRIG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PETG_LEMMI
Sequence: MIEVLLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: G6PI_BACAH
Sequence: MSTHVTFDYSKALSFIGEHEITYLRDAVKVTHHAIHEKTGAGNDFLGWVDLPLQYDKEEFARIQKCAEKIKNDSDILLVVGIGGSYLGARAAIEMLNHSFYNTLSKEQRKTPQVLFVGQNISSTYMKDLMDVLEGKDFSINVISKSGTTTEPALAFRIFRKLLEEKYGKEEARKRIYATTDKARGALKTLADNEGYETFVIPDDVGGRFSVLTPVGLLPIAVSGLNIEEMMKGAAAGRDDFGTSELEENPAYQYAVVRNALYNKGKTIEMLVNYEPALQYFAEWWKQLFGESEGKDQKGIFPSSANFSTDLHSLGQYVQEGRRDLFETVLKVGKSTHELTIESEENDLDGLNYLAGETVDFVNTKAYEGTLLAHSDGGVPNLIVNIPELNEYTFGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEELKAELEERLK
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_SALTI
Sequence: MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKIIELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCPL3_CAEEL
Sequence: MSNVTPKLVWPEDDYVDESLLEDHQGPARLEYDALVMLANLPPLTEEIMSRCPALPVKTRSTPEYTLVLDLDETLVHCSLTPLDNATMVFPVVFQNITYQVYVRLRPHLRTFLSRMAKTFEIIIFTASKKVYANKLCDILDPRKNHIRHRLFREHCVCVFGNYVKDLTILGRDPSKTMILDNAVQSFAYQLDNGIPIESWFHDRNDTELLKLCSFLEAIPTLGRDVREILRHKYRLRDHIPFYSIIHQQEGPGRLPLLEVAPPPVTEPNDEQLITQVVQKHPQLVQG
What is the function of this protein?
Probable phosphatase.
What are the official names of this protein?
CTD small phosphatase-like protein 3, CTDSP-like 3.
What is the protein family that this protein belongs to?
Belongs to the CTDSPL2 family.
Protein: FADJ_ALIF1
Sequence: MKNTSAFAWTKDDEQIAWLTIDVPNEKMNTLQAAFAEQVTQVLDEIEEQQAHIKGLVIQSGKPDNFIAGADINMIANCQNASEAQALAEKGQHLFQRIEDLPFATVAAIHGPCLGGGLELALACDYRVCSDDNKTKLGLPEVQLGLLPGSGGTQRLPRLIGLLPSLDIILTGKQLRPKTALKLGVVDASVPHTILSRIAADFALKKKAKRKLTAKEWGLSRNPLGRNVIFSQAEKQAQKKARGNYPAIAAILDCIEHGLDKGMKKGLQREAEQFARLAMTPESAALRSLFFAMTEMKKEKGSDAEPKSIDYVGVLGGGLMGGGIAHVSIAKAKKKVTIKDINNDGLLNAYQYHYQRLDTLRKRRIISKAQLQQQMLQLTGVTEFDGFKKLDVVVEAVFEDLNLKQEMVKAVQEQGKEDVIFATNTSSLPIGQIAEGAQKPENIVGLHYFSPVEKMPLVEVIPHATTSDETISTVVALAKQQGKTPIVVKDSAGFYVNRILAPYMNEAARLLLAGEPIEVLDEALLDFGFPVGPISLLDEVGVDIGAKIMPILEAELGDRFRSPDVFQTLIDDKRLGKKTKRGFYVYKGKKKEPDQEVYTLLNIKPQSQLSKNEIAMRCVLPMLAEAKRCLDEGIIASERDGDIGAIFGIGFPPFLGGPFTYMNTLGEEKLATLMRNYADKYGDRFIE
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROGDI_RAT
Sequence: MATAMAASAAERAVLEEEFRWLLHAEVHAVLRQLQDILKEASLRFTLPGPSTEGPAKQENFILGSCGTDQVKGVLTLQGDALSQADVNLKMPRNNQLLHFAFREDKQWKLQQIQDARNHVSQAIYLLANRDESYQFKTGAEVLKLMDAVMLQLTRARNRLTTPATLTLPEIAASGLTRMFAPTLPSDLLVNVYINLNKLCLTVYQLHTLQPTSTKNFRPAGGAVLHSPGAMFEWGSQRLEVSHVHKVECVIPWLNDALVYFTVSLQLCQQLKDKISVFSSYWSSRPF
What are the official names of this protein?
Protein rogdi homolog.
What is the protein family that this protein belongs to?
Belongs to the rogdi family.
What are the subcellular locations of this protein?
Nucleus envelope. Presynapse. Cell projection, axon. Perikaryon. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Detected primarily at presynaptic sites on axons, and to a lesser degree in soma and dendrites. Not detected at post-synaptic sites.
Protein: VHED_BPR08
Sequence: MFKRKSTAELAAQMAKLNGNKGFSSEDKGEWKLKLDNAGNGQAVIRFL
What is the function of this protein?
Binds preferentially to single-stranded DNA and therefore, destabilizes double-stranded DNA.  It is involved in DNA replication, repair and recombination.  Binds ss-DNA as the replication fork advances and stimulates the replisome processivity and accuracy.
What are the official names of this protein?
Single-stranded DNA-binding protein, Gp32, Helix-destabilizing protein.
Protein: YEBF_SALG2
Sequence: MNKRGALLSLLLLSASVSAFAASTESKSVKFPQCEGLDAAGIAASVKRDYQQNRIVRWADDQKKVGQADPVAWVNVQDVVGQNDKWTVPLTVRGKSADIHYQVIVDCKAGKAEYKPR
What are the official names of this protein?
Protein YebF.
What is the protein family that this protein belongs to?
Belongs to the YebF family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLSA_ECOL6
Sequence: MTTVYTLVSWLAILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLAVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEENSSVAAPLFKLCERRQGIAGVKGNQLQLMTESDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWPELMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMIMIDNYIAYTGSMNMVDPRYFKQDAGVGQWIDLMARMEGPIATAMGIIYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTAAYSAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSMLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLAIDDKGFGADLAAVQDDYISRSRLLDARLWLKRPLWQRVAERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL11_MOUSE
Sequence: MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:36517592).  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:36517592).  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:36517592).  As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:36517592).  It also couples ribosome biogenesis to p53/TP53 activation (PubMed:21804542).  As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:21804542).  Promotes nucleolar location of PML (PubMed:15195100).
What are the official names of this protein?
60S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: MENC_EDWI9
Sequence: MRQATLYRYRLPVDAGVALRNQRLKSRDGLLVRLHEDGREGWGEIAPLPEFSHETLPEAQEAACRLLAQWQVGAAPAESPLPSVAFGLSCAQAELSGTLPQAANYRSATLCNGDPDALFQVLQSIPGEKVAKVKVGLYEAVRDGMIVNLLLEALPDLHLRLDANRSWTRAKADGFAKYVNPDWRDRILFLEEPCKTRDESRAFARDTGIAIAWDESVRDADFRVEAEPGVAAIIIKPTLTGSLQRCRQLVTQAHQAGLSAVISSSIESSLGLSQLARMAAWLTPGTPPGLDTLMLMQAQLLRAWPACTLPLWGEDTLDVVWQG
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: RNH3_STAA9
Sequence: MANIVFKLSDKDITTLMSRITFDTENLPQGMKARAKYQNTTVNIYQSGKVMFQGNHAEAVSKELLPQHSQLNTNKTKKKNMANSSLEQTLMYDQFNCIGSDEAGSGDYFGPLTVCAAFVTKEHVPILKTLGVDDSKKLTDTKIVELAEQLVAFIPHSLLTLHNDKYNIQQAKGWTQVKMKAVLHNEAIKNVLEKIDSSQLDYIVIDQFAKREVYSHYALSDIPLPKKTKFETKGESKSLAIAVASIISRYAFITYMDQISKYINMTIPKGAGAKVDVIAAKIIKKYGLSRLDTISKKHFKNREKAQKILKPL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNAS_XENLA
Sequence: MGCLGNSKTEDQRNEEKVQRETNKKIEKQLQKDKQVYRATHRLLLLGAGESGKSSIVKQMRILHVNGFNAEEKKTKVQDIKNNIKEAIETIVTAMGNLSPPVELVNPENQFRIDYILNLPNYKDFEFSPEFYEHTKTLWQDEGVRACYERSNEYQLIDCAQYFLDKIDIVKQNDYTPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNHTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVNAGKSKIEDYFPEFARYTTPDDATPEVGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).  Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP.  GNAS functions downstream of several GPCRs, including beta-adrenergic receptors.  Stimulates the Ras signaling pathway.
What are the official names of this protein?
Guanine nucleotide-binding protein G(s) subunit alpha, Adenylate cyclase-stimulating G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(s) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: YC018_YEAST
Sequence: MYSHENHVNFQIVVGIPLLIKAVILCIQNILEVLLEDIGILKMESIFLHTNITIIPHSVLYVSLSYYIINPCTSASSNFDDSFS
What are the official names of this protein?
Putative uncharacterized protein YCR018C-A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CHDC_GEOSW
Sequence: MSEAAQTLDGWYCLHDFRSIDWSAWKTLTSDEREAAIREFLSLVEKWQETEDKQEGSHAIYTIVGQKADIMFMILRPTIEELNEIETALNKTKLAEFLVPAYSYVSVVELSNYLASGDEDPYQIPEVRRRLYPILPKTKHVCFYPMDKRRQGNDNWYMLSMEERRNLMRAHGLTGRKYAGKVTQIITGSVGLDDFEWGVTLFSDDALQFKKLVYEMRFDEVSARYGEFGSFFVGNRLTVEKVPVFLHV
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: RL24_LEPBP
Sequence: MATKLAYRGSEPTKFKKTKIKKDDEVLVISGKEKGKKGKVLAVDKRKDRVYIEGVNKRKRFVRPTQENPGGGAIEIEFPIHISNVMFHDAKAENKAKPKKKIKAVRLGFAKKDGKSVRVTRPEGKEV
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: FADE_ECOLI
Sequence: MMILSILATVVLLGALFYHRVSLFISSLILLAWTAALGVAGLWSAWVLVPLAIILVPFNFAPMRKSMISAPVFRGFRKVMPPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPRLTAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLKEHRFFAMIIKKEYGGLEFSAYAQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKDHYLPRLARGQEIPCFALTSPEAGSDAGAIPDTGIVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEKLLGGAEDLGITCALIPTTTPGVEIGRRHFPLNVPFQNGPTRGKDVFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIRRQFKISIGKMEGIEEPLARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGQSNFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMEAAKNNDVNAFDKLLFKHIGHVGSNKVRSFWLGLTRGLTSSTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGSLKRRERISARLGDILSQLYLASAVLKRYDDEGRNEADLPLVHWGVQDALYQAEQAMDDLLQNFPNRVVAGLLNVVIFPTGRHYLAPSDKLDHKVAKILQVPNATRSRIGRGQYLTPSEHNPVGLLEEALVDVIAADPIHQRICKELGKNLPFTRLDELAHNALVKGLIDKDEAAILVKAEESRLRSINVDDFDPEELATKPVKLPEKVRKVEAA
What is the function of this protein?
Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation.  Is required for E. coli to utilize dodecanoate or oleate as the sole carbon and energy source for growth.
What are the official names of this protein?
Acyl-coenzyme A dehydrogenase, ACDH, Acyl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
Protein: RUTC_HALO1
Sequence: MPMKPINPSQFPKPIAPYSAGAMADNVVYVSGTLALGEGGQVLHVGDAKAQTRHVLETIKTTLEAAGGGMADITFNHIFVKSWDDYKAINEVYAEYFPGDKPARYCIQCGLVKPELLVEIASIAHLSPKE
What is the function of this protein?
Involved in pyrimidine catabolism.  Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously.  RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.
What are the official names of this protein?
3-aminoacrylate deaminase RutC, 3-AA deaminase.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: NAGPA_HUMAN
Sequence: MATSTGRWLLLRLALFGFLWEASGGLDSGASRDDDLLLPYPRARARLPRDCTRVRAGNREHESWPPPPATPGAGGLAVRTFVSHFRDRAVAGHLTRAVEPLRTFSVLEPGGPGGCAARRRATVEETARAADCRVAQNGGFFRMNSGECLGNVVSDERRVSSSGGLQNAQFGIRRDGTLVTGYLSEEEVLDTENPFVQLLSGVVWLIRNGSIYINESQATECDETQETGSFSKFVNVISARTAIGHDRKGQLVLFHADGQTEQRGINLWEMAEFLLKQDVVNAINLDGGGSATFVLNGTLASYPSDHCQDNMWRCPRQVSTVVCVHEPRCQPPDCHGHGTCVDGHCQCTGHFWRGPGCDELDCGPSNCSQHGLCTETGCRCDAGWTGSNCSEECPLGWHGPGCQRPCKCEHHCPCDPKTGNCSVSRVKQCLQPPEATLRAGELSFFTRTAWLALTLALAFLLLISTAANLSLLLSRAERNRRLHGDYAYHPLQEMNGEPLAAEKEQPGGAHNPFKD
What is the function of this protein?
Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step.  Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.
What are the official names of this protein?
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, Mannose 6-phosphate-uncovering enzyme, Phosphodiester alpha-GlcNAcase.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Note=Cis/medial Golgi.