PharMolix/UniProtQA huggingface dataset:
Protein: UVRC_FRACC
Sequence: MADPASYRPAPGSIPETPGVYRFRDEHGRVLYVGKAKNLRARLANYFAELHTLHPRTQHMVSSASSVDWTVVSTEVEALQLEYTWIKQFDPRFNVRYRDDKSYPSLAVTLHEEFPRLQVMRGPKRKGVRYFGPYAHAWAIRETLDLLLRVFPARTCSGGVFKRAAQVGRPCLLGYIDRCSAPCVGRVDAATHREIVEDFCDFMSGQTGRYLRRLEREMQQAAQAQEYERAARLRDDIGALRRAVEKQAVVLPDGTDADVIAFAEDELEAAVAVFYVRGGRVRGQRGWVVDKLDEVTTADLVEQFLTQEYLDGTGAASTGTAGSTVPTTTAGSQGEGIPREILVPALPPDVEAVTELLGAARGSRVEVRVPRRGDKRTLLETVERNAKQAFALHRTKRASDLTARSRALAELQEALELPDAPLRIECFDVSNTQGTNVVASMVVFEDGLPRKSEYRRFAIRGIAGREGAGREGAGDDVASMYETIHRRFSRYLAERSRIADIADIAELGDIAGAPGAAQPIDPGTGRPRRFAYPPNLVVVDGGAPQVAAAARALDELGIDAGPGGVALCGLAKRLEEVWLPDTADPVILPRTSEALYLLQRVRDEAHRFAIAYHRQKRSTAMVASALDEVPGLGDTRRKALLRHFGSVAKIRAASAEQIAQVSGIGPRTAAAIVTALARSAPGRADAPAPVVDPRTGEILDTETVS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPAC_LISMO
Sequence: MTKTLVFGHKNPDTDTICSAISYAELKKAQGADIEAVRLGELNSETAFVLDYFQVTAPRLVQTVANEVSEVALVDHNERQQSVDDIDDVTVTAVVDHHRIANFETSDPLYYRAEPVGCTTTILLKMFRENEVEVSKTVAGLMLSAIISDTLLFQSPTCTEEDKVAAQKLAQIADVDIQSYGMEMLKAGADVSKKTVAELLLDAKEFNMNDNKVEIAQINVVDVNDVLSRRAEVEALMTQNIVDKGLDLYLFVITNILTNDSVGIAIGSKTAVVEEAYGVKFVENQAPLKGVVSRKKQVVPILTDTFAK
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_LISMH
Sequence: MRVKHKPWAKDRLEEFPAIYIKNPEDFKGQWQEVFGNNNPIHIEIGSGKGQFISGMAKANPEINYIGIEMIESVLVSALDKAIEADVPNLRLVARDAKLLEECFEKGEVAQIYLNFSDPWPKKRHTKRRLTNPTFLTIYERLLPKAGEIHFKTDNRSLFEYSLVAFSEYNMLLTFVSLDLHNSDYEGNIKTEYEEKFSAKGFPIYRLEAKFDRN
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: PVK1_GROPO
Sequence: GSSGLIPFGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, GroPo-PVK-1, PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RED2_PLARH
Sequence: MSKIWILLLLVGAVQFARGFPALEEEQEDDVIDWPSFEYDLSDEERGKGLDWLKKQWGKLKNSFKKVGAKVTATFNKGRDYLKKKGIKVDPLNCQGNKCRSCVIFTLKPKKFCIEYVFSTSAITVSLIKEKDDEEKVLLGPFTIKTGNIPKCCKLGSFIGELCLQGVEGRLKSSNGKPHVNLCVGLLLKKFGCGAKICVSYVDGKFSVSFKPKLFAGDEENGTIMEAGEKEDEGKVIDAVPE
What is the function of this protein?
Highly abundant protein that may be responsible for the observed disruption of sensory neuron membranes, since it is homologous to proteins such as trialysin, which forms pores in lipid bilayers (Probable).  Probable insecticidal toxin (By similarity).
What are the official names of this protein?
Venom redulysin 2, Red2.
What is the protein family that this protein belongs to?
Belongs to the redulysin-like family.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPB_ECOL6
Sequence: MYQDKILVRQLGLQPYEPISQAMHEFTDTRDDSTLDEIWLVEHYPVFTQGQAGKAEHILMPGDIPVIQSDRGGQVTYHGPGQQVMYVLLNLKRRKLGVRELVTLLEQTVVNTLAELGIEAHPRADAPGVYVGEKKICSLGLRIRRGCSFHGLALNVNMDLSPFLRINPCGYAGMEMAKISQWKPEATTNNIAPRLLENILALLNNPDFEYITA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_ANOFW
Sequence: MAKEIKFSEEARRAMLRGVDKLADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDPFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGIRKGIEKAVAVAVEELKAISKPIEGKDSIAQVAAISAADEEVGQLIAEAMERVGKDGVITLEESKGFTTELDVVEGMQFDRGYVSPYMITDSDKMEAVLENPYILITDKKVSSIQELLPVLEQVVQQGKPLLIIAEDVEGEALATLVVNKLRGTFTAVAVKAPGFGDRRKAMLQDIAILTGGEVITEELGRELKSTTIASLGRAAKVVVTKEHTTIVDGAGRAEDIQARINQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNATRAAVEEGIVAGGGTALMNVYSKVAAIEAEGDEATGVKIVLRAIEEPVRQIAQNAGLEGSVIVERLKTEKPGIGFNAATGEWVDMIEAGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENKNTPGMPDMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPXA_ECOLI
Sequence: MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS
What is the function of this protein?
Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031, PubMed:9473036).  Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity (PubMed:9401031, PubMed:17259177, PubMed:24492262).  The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition (PubMed:16166523, PubMed:17259177, PubMed:25207645).  Involved in several diverse cellular processes, including the functioning of acetohydroxyacid synthetase I, the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid (PubMed:8432716), and the synthesis, translocation, or stability of cell envelope proteins (PubMed:7883164).  Activates transcription of periplasmic protease degP, probably by phosphorylating the cognate response protein CpxR; overexpression of an outer membrane lipoprotein NlpE also leads to transcription of degP via CpxRA (PubMed:7883164).  Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation (PubMed:11830644).
What are the official names of this protein?
Sensor histidine kinase CpxA.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1656_ARCFU
Sequence: MRKILLFATVIGFLIMVSGTLSYFYDVESQRSTFKSGHWASEIYPTVSFVKKESPVKIDFYGKPNEEYSYDVIFRIVDAPGIPKLSWDGDDFVQFSLRKNVNDWEVGMHLSPQTNGTYVGELTISYPSYPYKVVEIPVTITLEE
What are the official names of this protein?
Uncharacterized protein AF_1656.
Protein: RL15_STRPG
Sequence: MKLHELKAAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGGGVRLGFEGGQTPLFRRIPKRGFTNINTKEYALVNLDQLNVFDDGTEVTPAILKDAGIVRAEKSGVKVLGNGELTKKLTVKAAKFSKSAEAAIIAKGGSIEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: HIS4_SYNP6
Sequence: MDVIPAIDLLGGQCVRLFQGDYDQAEVYGKDPVGMALRWAEAGAQRLHLVDLDGAKEGSPVNAEAIATIAQRLSIPVQVGGGLRDRDTVARLLDSGVERAILGTVAVERPALVEALAGEFPGQIAVGIDARSGKVATRGWLEDSGLTAVALAQQMADLGACALICTDIGRDGTLQGPNLEELRAIAAAVSIPVIASGGVGSLTDLLSLLPLEAQGVSGVIVGKALYTGAVDLQEALRAIGSGRWQDVAVDDSSRLA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RB11B_DICDI
Sequence: MVLKTIEYDYLCKIVVIGDSGVGKSNLLSRYNKNEFSVGKLSTIGVEFSTKTLKIDNKLIKLQLWDTAGQEKYNSITESYYKGAIGALIVYNIADRNSFNNLEKWLKKFRENAHQDYGIMLVGNKSDLKEYREVSTLEGKQFAEKHYMQFIETSALDSNNVETAFNNLFNFIYYSLFKNKTMTLDINNNGNNNSNIMVGDCEPIQFDQRYTINKPVYDCC
What are the official names of this protein?
Ras-related protein Rab-11B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: MOAA_RHOCA
Sequence: MLPDPLCDGFGRDVRYLRVSVTDRCDLRCSYCMKEDVTFLPRNQVLSLEELDRLGVRKLRVTGGEPLVRRGIGTFFAAMGTHLRAGRLDELTLTTNGTQLAAHAQSLAECGVKRVNVSLDTLQAEKYARLTRFGRIEQVFAGIAAAQAAGLRVKLNAMALKGVNDDEIFALTDWAAAHHCDLTFIELMPMGDIPAGTRLDQFWPLDDVRAHLETRFRLIDNGLNTGGPARYVTVAQTGQRIGFISPLSHNFCTSCNRVRLTCKGELYTCLGQEGSSDLRPVLRAGVEGEALAREIRAAIARKPAGHAFGYGPCSVAGQMVRGMNHTGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: I5L_FOWPN
Sequence: MEIARETLITIGLTILVVLLIITGFSLVLRLIPGVYSSVSRSSFTAGRILRFMEIFSTIMFIPGIIILYAAYIRKIKMKNN
What are the official names of this protein?
Protein I5 homolog.
What is the protein family that this protein belongs to?
Belongs to the Chordopoxvirinae I5 family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Note=Probably localizes to the membrane of mature virions (MV).
Protein: BMP15_HUMAN
Sequence: MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKPRLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTNVARPHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR
What is the function of this protein?
May be involved in follicular development.  Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
What are the official names of this protein?
Bone morphogenetic protein 15, BMP-15, Growth/differentiation factor 9B, GDF-9B.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL31B_STRU0
Sequence: MRKDIHPDYRPVVFLDTTTGYKFLSGSTKSSKETIEFEGETYPLIRVEISSDSHPFYTGRQKFTQADGRVDRFNKKYGLKDANAAK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: NUA_ARATH
Sequence: MPLFMPDEELARLSSDAASVVAERADEYIRKIYAELDSVRAKADAASITAEQTCSLLEQKYLSLSQDFSSLESQNAKLQSDFDDRLAELAQSQAQKHQLHLQSIEKDGEVERMSTEMSELHKSKRQLMELLEQKDAEISEKNSTIKSYLDKIVKLTDTSSEKEARLAEATAELARSQAMCSRLSQEKELTERHAKWLDEELTAKVDSYAELRRRHSDLESEMSAKLVDVEKNYIECSSSLNWHKERLRELETKIGSLQEDLSSCKDAATTTEEQYTAELFTANKLVDLYKESSEEWSRKAGELEGVIKALEARLSQVESSYKERLDKEVSTKQLLEKENGDLKQKLEKCEAEIEKTRKTDELNLIPFSNFTRRVDNSGTSNMIEESQAVISKVPAGVSGTALAASLLRDGWSLAKIYEKYQEAVDAMRHEQLGRKEAEMILQRVLSELEEKAGFIQEERGEYERVVEAYCLVNQKLQDSVSEQSNMEKFIMELKADLRRRERENTLLQKDISDLQKQVTILLKECRDVQLRCGAARDDDEDDYPLLSDVEMEMESEADKIISEHLLKFKDINGLVEQNVKLRNLVRSLSEQIESRETELKETFEVDLKNKTDEASAKVATVLKRAEEQGQMIESLHTSVAMYKRLYEEEQKLHSSDSRSSDLSPAVVPGRKNFLHLLEDSEEATKRAQEKAFERIRILEEDFAKARSEVIAIRSERDKLAMEANFAREKLEGIMKESERKREEMNSVLARNIEFSQLIIDHQRKLRESSESLHAAEEISRKLSMEVSVLKQEKELLSNAEKRASDEVSALSQRVYRLQATLDTVQSTEEVREETRAAERRKQEEHIKQLQREWAEAKKELQEERSNARDFTSDRNQTLNNAVMQVEEMGKELANALKAVSVAESRASVAEARLSDLEKKIRSSDPKTLDMDSGGIVSLSDKEMSIELRTAKEEIEKLRGEVESSKSHMLQYKSIAQVNETALKQMESAHENFRLEAEKRQRSLEAELVSLRERVSELENDCIQKSEQLATAAAGKEDALLSASAEIASLREENLVKKSQIEAMNIQMSTLKNDLETEHEKWRVAQRNYERQVILLSETIQELTKTSQALAALQEEASELRKLADARGIENSELNAKWSEEKLMLEQQKNLAEKKYHELNEQNKLLHSRLEAKHLNSAEKNSRSGTISSGSTDSDHLEDSGLQRVVHYLRRTKEIAETEISLMRQEKLRLQSQLESALKMAESARGSLTAERASTRASLLTDDGIKSLQLQVSEMNLLRESNMQLREENKHNFEKCQEMREVAQKARMESENFENLLKTKQTELDLCMKEMEKLRMETDLHKKRVDELRETYRNIDIADYNRLKDEVRQLEEKLKAKDAHAEDCKKVLLEKQNKISLLEKELTNCKKDLSEREKRLDDAQQAQATMQSEFNKQKQELEKNKKIHYTLNMTKRKYEKEKDELSKQNQSLAKQLEEAKEEAGKRTTTDAVVEQSVKEREEKEKRIQILDKYVHQLKDEVRKKTEDLKKKDEELTKERSERKSVEKEVGDSLTKIKKEKTKVDEELAKLERYQTALTHLSEELEKLKHADGNLPEGTSAVQVLSGSILNDQAAAYVSAVEYFERVARSIASNSQVSTKPTDMVTEPSSGIPAAEPSTMTRVPSSTPLIKSPVATTQQLPKVASDNKEKRLISQKPSTEFRRPSGRRIVRPQLVKPEESPKVDVDMPEAEGTGDEGKQPAAHEPESQVTTSVRPVQTLVRKRQADSLVSEPQQDSLTQGETSSEIAPPASKKAKGSESHPDTSEGENLAKEPAIDELMDATTTTDGDNEETEAENAEEKTEEYVEAQQDNEADEPVEESPTETETIPTEEESRDQTEEENQEPLTDMESDKEEGELDLDTLEDLEEGTDVASMMRSPEKEEVQPETLATPTQSPSRMETAMEEAETTIETPVEDDKTDEGGDAAEEAADIPNNANDQQEAPETDIKPETSAATTSPVSTAPTTSSTLASAITSSGAPETEDPKRAPSPGGGSSTIVTLADRAQMKRRERIANIVVSRAPNPATRGARGRTVNLRGGGRLLPRGGRAPRGGRGQSPSPP
What is the function of this protein?
Component of the nuclear pore complex.  Acts as a docking site for activities required for desumoylation and mRNA export.  Required for the proper expression or localization of a subset of miRNAs.  Plays a role in meristematic cell division by interacting with spindle assembly checkpoint proteins.
What are the official names of this protein?
Nuclear-pore anchor, Protein TRANSLOCATED PROMOTER REGION, AtTPR.
What are the subcellular locations of this protein?
Nucleus envelope. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Note=Located at the inner surface of the nuclear envelope during interphase and in the vicinity of the spindle during prometaphase.
Protein: LGT_CLOBH
Sequence: MNPIAFHVGNLAIRWYGVIISMGTALGLLLAMYNCKIREASYDEFINMFLIAFPSAIIGARLYYVIFEFEDYRDNLINIFNTRQGGLAIHGGIIFGVLAVYIYLKYRKESFFEYVDVAAPSIILGQAIGRWGNFFNSEAHGGPVTKEFISKFPQFIQNGMFIEGTYYHPTFLYESIWNFIICIFLVYLLKKTKKKGIVFMAYIGLYSLGRFFIEGLRTDSLYLGSIRVAQLISVLGIILSIFFIYNIIKKEKRY
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS16_NOCFA
Sequence: MAVRIKLTRLGKIRNPQYRVVVADARTRRDGRAIESIGKYHPKEEPSLIEIDSERVQYWLSVGAQPTEPVQRLLEITGDWQKFKGLPGAEGTLKVKAAKPSKLDLFNAALAAAENEPVAEAVTPKKKAKKDDAAAESTEAEAAE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RUVC_RALSO
Sequence: MRILGIDPGLRTTGFGVLERHGHQLVYVASGTIKSDGNADLPSRLKTLYDGVSELVRTYRPDCASIEKVFVNVNPQSTLLLGQARGAVICGLMSGNLPVFEYTALQLKQAVVGYGRANKDQVQDMVVRLLNLEGRPGTDAADALGVAICHAHGGETLAAMAGLAPQLARKGLRVRRGRLVG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: ARGB_MORPR
Sequence: MTMTATMTTPLVLKLGGALLENETALEQLFTALSEYKSTSSRPLVLVHGGGCFVDELLAKMNIVSEKKNGLRITPFSDIGYITGALAGTANKVLMAQGLKSGAKVVGLSLADGGIATVTQSTAGLGAVGECEAGDPTLLTALLSGGFLPIISSIGIDAQGQLLNVNADQAATAICETLDADLVMLSDVAGILDADMQLIPEMNSNYAAELIAAGVINGGMEVKVKAALKAAASLNRDIKLASWKVPERLVALLNGEVEGTKVSS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GA45G_MOUSE
Sequence: MTLEEVRGQDTVPESTARMQGAGKALHELLLSAHGQGCLTAGVYESAKVLNVDPDNVTFCVLAADEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGADEEGGAPGDLHCILISNPNEDTWKDPALEKLSLFCEESRSFNDWVPSITLPE
What is the function of this protein?
Involved in the regulation of growth and apoptosis.  Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
What are the official names of this protein?
Growth arrest and DNA damage-inducible protein GADD45 gamma, Cytokine-responsive protein CR6.
What is the protein family that this protein belongs to?
Belongs to the GADD45 family.
Protein: TRMB_MYCTU
Sequence: MVHHGQMHAQPGVGLRPDTPVASGQLPSTSIRSRRSGISKAQRETWERLWPELGLLALPQSPRGTPVDTRAWFGRDAPVVLEIGSGSGTSTLAMAKAEPHVDVIAVDVYRRGLAQLLCAIDKVGSDGINIRLILGNAVDVLQHLIAPDSLCGVRVFFPDPWPKARHHKRRLLQPATMALIADRLVPSGVLHAATDHPGYAEHIAAAGDAEPRLVRVDPDTELLPISVVRPATKYERKAQLGGGAVIELLWKKHGCSERDLKIR
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: PTPB_STAAN
Sequence: MKILFVCTGNTCRSPLAESIAKEVMPNHQFESRGIFAVNNQGVSNYVEDLVEEHHLAETTLSQQFTEADLKADIILTMSYSHKELIEAHFGLQNHVFTLHEYVKEAGEVIDPYGGTKEMYVHTYEELVSLILKLKDIIC
What is the function of this protein?
Dephosphorylates the phosphotyrosine-containing proteins.
What are the official names of this protein?
Low molecular weight protein-tyrosine-phosphatase PtpB, Phosphotyrosine phosphatase B, PTPase B.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Protein: RNY_LISM4
Sequence: MTIAITIISSLLFLIVGLVVGSLIFKSSTEKKLAAARGTAELIVEDAKKEAETTKKEALLEAKEENHRLRTEIENELRGRRTETQKAENRLLQREENLDRKDTSLSKREATLERKEESISKRQQQIEEKESKLAEMIQAEQTELERISALSKEEAKSIILNQVEEELTHDTAIMVKESENRAKEESDKKAKNILSLAIQRCAADHVAETTVSVVTLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRREIARIALEKLVQDGRIHPARIEEMVDKARKEVDEHIREVGEQATFEVGIHSIHPDLIKILGRLRYRTSYGQNVLNHSLEVSKLAGILAGELGEDVTLAKRAGLLHDIGKAIDHEIEGSHVEIGVELATKYKENDVVINSIASHHGDTEATSVIAVLVAAADALSAARPGARSETLENYIRRLEKLEEISESYDGVEKSYAIQAGREVRIIVEPDTIDDLSSYRLARDIRKRIEEELDYPGHIKVTVIRETRAVEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: UPPS_VIBVY
Sequence: MQNSQLFTESLPKHIAIIMDGNGRWAKSKGQPRVFGHKKGVSAVRKTIAAASKLNIQAITLFAFSSENWRRPEEEVGLLMELFITVLSSEVKKLHKNNLRLRIIGDTSRFSERLQKKIVEAQELTASNTGMVINVAANYGGKWDITQAVQKVAQQVALGDLSAEDITEDDIAKHLTMSDLPEVDLLIRTSGECRISNFMLWQMAYAEMYFTPVFWPDFGEESLIEAITWFVNRERRFGCTGEQIKALMSAQ
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP).  UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
What are the official names of this protein?
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), Ditrans,polycis-undecaprenylcistransferase, Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: ARP4_YEAST
Sequence: MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRFR
What is the function of this protein?
Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair.  ARP4 recognizes H2AS128ph (gamma-H2A) and is required for NuA4 complex integrity.  Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Component of the INO80 complex which remodels chromatin by shifting nucleosomes.  Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates.  The INO80 complex is involved in DNA repair by associating to gamma-H2A as a response to DNA damage.
What are the official names of this protein?
Actin-related protein 4, Actin-like protein ARP4, Actin-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y2805_MYCBO
Sequence: MPRRSPADPAAALAPRRTTLPGGLRVVTEFLPAVHSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTPTRSAVDIAQAMDAVGGELNAFTAKEHTCYYAHVLGSDLPLAVDLVADVVLNGRCAADDVEVERDVVLEEIAMRDDDPEDALADMFLAALFGDHPVGRPVIGSAQSVSVMTRAQLQSFHLRRYTPERMVVAAAGNVDHDGLVALVREHFGSRLVRGRRPVAPRKGTGRVNGSPRLTLVSRDAEQTHVSLGIRTPGRGWEHRWALSVLHTALGGGLSSRLFQEVRETRGLAYSVYSALDLFADSGALSVYAACLPERFADVMRVTADVLESVARDGITEAECGIAKGSLRGGLVLGLEDSSSRMSRLGRSELNYGKHRSIEHTLRQIEQVTVEEVNAVARHLLSRRYGAAVLGPHGSKRSLPQQLRAMVG
What are the official names of this protein?
Uncharacterized zinc protease Mb2805c.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.