PharMolix/UniProtQA huggingface dataset:
Protein: TAZ_PONPY
Sequence: MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKVLTDFIQEEFQRLKTQAEQLHNHLQPGR
What is the function of this protein?
Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity).  Its role in cellular physiology is to improve mitochondrial performance (By similarity).  CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity).  Catalyzes the transacylacion between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL.  Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations.  Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate.  Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution.  Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor.  CoA-independent, it can reshuffle molecular species within a single phospholipid class.  Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL.  Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane.  Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes.  Essential for the final stage of spermatogenesis, spermatid individualization (By similarity).  Required for the initiation of mitophagy (By similarity).  Required to ensure progression of spermatocytes through meiosis (By similarity).
What are the official names of this protein?
Tafazzin, Taz.
What is the protein family that this protein belongs to?
Belongs to the taffazin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: V022_FOWPN
Sequence: MAYRRKSAFKRAIDEDDVDIIRKLLSYKPIDLNKPGSKNRTILCRAVSMKSHKVAEFLLSNGSKMSACKVPPLIISVRNKDLTMAKILVSYGASVDVCYKGETPLLTAIKTGYIEIIDYLLSLEPSGPYPGHDMIYDKLTLESCSLLIKNNIRLDIPDRYGHTALYYAVKKGNLSLIKLLVENKAITDNIERIKILRRCIVTHYNIEVLKILSLDRDILGTEGTTALHYAVEAERLEAVRYLLDIGCDPKVLDEHSVSPLYYAIKRKNKIILDELIKFYTVEFMVNMDKRTLPLAMYYCSIDELKNLMHGIKDIALSEDYLSELLYESIKTNNPEIVSLILGLGANINKRDLYGNIPLQTAIIYQTDNVFNLLLQKGADVNAKNSDGNTILHTLAACCKYKKIKLVLDLGSDINSVNTNGRTPIEEACPCKKTIRTLISHLIIMIKKNKELIKDPLVIRSVSFINGIEYYKNIMLQCENELNELINQKLVRGYSLFDFVIEKDYNVIARFVNHPKLKVLKQTANVYKELADKNIGMSLTRYTLLERAVLTTEPYLHMLPLEIRSIICCFLSNNELEKL
What are the official names of this protein?
Putative ankyrin repeat protein FPV022.
Protein: RIMP_KLEP3
Sequence: MSTLEQKLTEMLTAPVEALGFELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVMDVEDPITVAYNLEVSSPGLDRPMFTAEHYQRFTGEEVALVLRMAVQNRRKWQGIIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_LACCB
Sequence: MQFIAASIAAGIAAFGASIGNGMVISKTLEGMARQPEMAGTLRGTMFIGVGLIEAVPILSVVVAFMLMSR
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNAK_AGGAC
Sequence: MGKIVGIDLGTTNSCVAVMEGEKPRVIENAEGDRTTPSIIAYTNDNETLVGQPAKRQAVTNPKNTLFAIKRLIGRRFEDEEVKRDIDIMPFAITKADNGDAWVEVKGEKLAPPQISAEVLKKMKKAAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKGTGNKTIAVYDLGGGTFDLSIIEIDEVGGEKTFEVLATNGDTHLGGEDFDNRIINYLVDEFKKEQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHLNIKLTRAKLESLVEDLVAKSLEPVRIALKDAGKSPSEIDDVILVGGQTRMPLVQQEVEKFFGKAPRKDVNPDEAVAIGAAVQGGVLAGDVKDVLLLDVTPLSLGIETMGGVMTTLIEKNTTIPTKKSQVFSTAEDNQSAVTIHVLQGERKQASANKSLGQFNLEGINPVPRGMPQIEVTFDIDADGIIHVSAKDKGTGKEQQITIKSSSGLSDEEIQQMVRDAEANAESDRKFEELVQARNQADHLIHSTRKQLDEAGDKVPAADRGTIESALSDLEKAAKGEDKAVIEAKIKALAEVAQKLAQTAQPHGDPQQAQSNSKPNDDVVDAEFEEVKDNK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RS10_CHLTE
Sequence: MAVQQKIRIKLKSYDHSLVDKWALKIIDVVKQTEAIIFGPIPLPTKTHVYTVNRSPHVDKKSREQFAFSSHKRLIEIINPTARTIDMLMKLELPSGVDVEIKS
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: DAPAT_METTH
Sequence: MVTVNENYLLLKSSYIFSEINRRVEEFQRKNPDADIIRMGIGDVTRPLPEAVVEAFHRAVDEMAEEETFRGYGPEQGYPFLREAIAENDYASRGVDITADEIFISDGAKCDTGNIQEIFGLDNVVAVTDPVYPVYVESNVMAGRAGPADDDGRYSGLVYLPCTEENSFIPSLPEERVDLIYLCYPNNPTGTTLTEKQLAEWVDYARDSGSLILFDAAYEAYIQEDGIPHSIYEVEGAREVAIEFRSFSKNAGFTGTRCAFTVVPEELEVPDSSGRMHSVRELWNRRQTTKFNGVSYPVQRAAEAVYTPEGQREIRESIDYYMENARIIRESLERAGLRYYGGVNAPYIWIRTPEGMDSWQFFDTLLNDAEVVGTPGSGFGPSGEGYFRLTAFNSFRNTVKAMERISELSF
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.  Is also able to catalyze the reverse reaction in vitro, i. e.  the transamination of LL-diaminopimelate with 2-oxoglutarate to produce 2-oxo-6-aminopimelate (in equilibrium with tetrahydrodipicolinate) and glutamate.  Has maximal aminotransferase activity using 2-oxoglutarate as an amino group acceptor, and cannot use oxaloacetate instead of 2-oxoglutarate, although 2-oxoadipate can substitute with 21% relative activity.  Cannot use m-DAP, lysine or ornithine as the amino-group donor, when using 2-oxoglutarate as the amino-group acceptor.
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: HMENA_MYXGL
Sequence: ADQLARLRAEFQANRYLTEERRQNLARELSLNEAQIKIWFQNKRAKIKKASGVKNTLALY
What are the official names of this protein?
Homeobox protein engrailed-like A, EN-A.
What is the protein family that this protein belongs to?
Belongs to the engrailed homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMH_PARUW
Sequence: MPIPFYPHRSVLLEEVIEAFQPVQLKVFIDGTLGAGGHAEAILEHHPEIELYLGIDQDPNALNIANKRLEKWKQKILLKQGNFSQFDIFLKEIGFSSMDGLLVDLGVSSMQLDQPERGFSFSKDGPLDMRMNPEGKLTAADIVNTWSEHDLGKIFRDYGEEKKWRLAARTIVQARQVKQILTTTDLANLLKPAFAWNPKKGINPLTLIFQALRICVNRELDVLEQLVSKTFDYLKPGGRVAVISFHSLEDRIVKNELRLAASDKWETTGLGSGLFRDKKPVAKLVNRKPICPHEKEIKENPRSRSAKFRIAEKLEG
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPIA2_MOUSE
Sequence: MFQLGSLVVLCGLLIGNSESLLGELGSAVNNLKILNPPSEAVPQNLNLDVELLQQATSWPLAKNSILETLNTADLGNLKSFTSLNGLLLKINNLKVLDFQAKLSSNGNGIDLTVPLAGEASLVLPFIGKTVDISVSLDLINSLSIKTNAQTGLPEVTIGKCSSNTDKISISLLGRRLPIINSILDGVSTLLTSTLSTVLQNFLCPLLQYVLSTLNPSVLQGLLSNLLAGQVQLAL
What is the function of this protein?
Has strong antibacterial activity against P.  aeruginosa.
What are the official names of this protein?
BPI fold-containing family A member 2, Parotid secretory protein, PSP.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLMU_DESAP
Sequence: MDLAAVVLAAGRGTRMKSRRPKVLHRVAGRPMVGYVMEAVREAGANRIIVVAGYGHEEVAAVVNELGGEVVVQEPQLGTAHAVLQAEEKLADHRGQVLVVCGDTPLLRGETLSKLAVRHREADAAATVLTAFLDDPTGYGRVIRDAAGRFVRIVEQSDGTPEELAVREVSTGVFCFAAGGLFECLRRISPDNQQGEYYLPDALIVYLKNGLTVSTCPVEDPAEIYGINDRRQLAEVERLMRSAVLDYWMGEGVTVVDPASTYIDRAARIGRDTVIHPSSFIEGDSVIGEECEIGPNARLVRARLGDRVSVQYAVVLDSTIGERTTVGPFAYIRPGCEIGAGVKIGDFVEIKKSVVGNESKIPHLSYVGDAVIGEKVNVGAGTITCNYDGKKKWTTVIEDGAFIGSNTNLVAPVTVGRGAYVGAGSTIRRDVPPGALGVARSDQKNIPNWETRIRHEKKDNRQNNDK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_CAMJJ
Sequence: MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLADIKAKEPKGIILSGGPASVYATDAYFCDKGIFDLGLPVLGICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDSALFKNLPKKQTVWMSHSDKVENLPDGFEVLATSENSPFCVFGNEDKKFFALQFHPEVQHSEFGKNILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIKEQVIVVFVDNGLLRSGEKEQVEFMFKNTLGIDLISIDASEIFLSRLANVRDPEQKRKIIGNTFIEVFEEEAKKHKDVKYLAQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMGEVNRPSLELLRKVDVILLEELKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLENISRRIINEVEGINRVVYDISSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: Y1665_CHLTE
Sequence: MSGHSKWATIKRKKAATDQKRGSLFTKLVKEITIAAKMGGGDPTGNPRLRLAIDTARANSMPMDNIQRAIKRGTGELEGATYEEITYEGYGPGGIAIIIETATDNRNRTVADIRHLMSRGGGSLGESGSVGWMFKRKGSIEVPRSAISEDDLMELLLDAGLEELESDDEQYFTVLTDVKDLEPVKKALEEAGIPFENAKIDMIPDNYVELDVENARKALKLIDALENSDDVQAVYSNMDMSESVMSVLEEE
What are the official names of this protein?
Probable transcriptional regulatory protein CT1665.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBL2_SOLLC
Sequence: MGFTDKQEALVRDSWEFMKQDIPQLSLRFFSLILEIAPVAKNMFSFLKDSDELPENNPKLRAHAVKVFKMTCESAIQLREKGEVVVGETTLKYLGSIHLQKRVADPHFEVVKEALLRTVKEATGNKWKDEMKEAWSEAYDQLASAIKAEMHAEAAA
What is the function of this protein?
May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule.
What are the official names of this protein?
Non-symbiotic hemoglobin 2, Hb2, SOLly GLB2.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: Y0574_MYCTU
Sequence: MAGNPDVVTVLLGGDVMLGRGVDQILPHPGKPQLRERYMRDATGYVRLAERVNGRIPLPVDWRWPWGEALAVLENTATDVCLINLETTITADGEFADRKPVCYRMHPDNVPALTALRPHVCALANNHILDFGYQGLTDTVAALAGAGIQSVGAGADLLAARRSALVTVGHERRVIVGSVAAESSGVPESWAARRDRPGVWLIRDPAQRDVADDVAAQVLADKRPGDIAIVSMHWGSNWGYATAPGDVAFAHRLIDAGIDMVHGHSSHHPRPIEIYRGKPILYGCGDVVDDYEGIGGHESFRSELRLLYLTVTDPASGNLISLQMLPLRVSRMRLQRASQTDTEWLRNTIERISRRFGIRVVTRPDNLLEVVPAANLTSKE
What is the function of this protein?
Could be involved in the biosynthesis, transport or localization of poly-alpha-L-glutamine (PLG), a cell wall component.  Contributes to stress tolerance and virulence.
What are the official names of this protein?
Probable polyglutamine synthesis accessory protein Rv0574c.
What is the protein family that this protein belongs to?
Belongs to the CapA family.
Protein: HYBF_SHIB3
Sequence: MHELSLCQSAVEIIQRQAEQHDVKRVTAVWLEIGALSCVEESAVRFSFEIVCHGTVAQGCDLHIVYKPAQAWCWDCSQVVEIHQHDAQCPLCHGERLRVDTGDSLIVKSIEVE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HybF.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family. HybF subfamily.
Protein: BN3D2_MOUSE
Sequence: MAADGTLSRGGVGEAVEEEHPGALEPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRQLFPPEGPEKRPILGLDVGCNSGDLSVALYKHFLSPRDGETCSGASRELRILCCDIDPVLVERAERDCPFPEALTFITLDIMDQESRKVPLSSFLSQFGRSVFDMVFCMSVTMWIHLNHGDRGLCEFLAHVSSLCSYLLVEPQPWKCYRAAARRLRKLGLHSFDHFRSLAIRGDMAKQIVRILTQDHGMELACCFGNTSWDRSLLLFRAKHTHETQAIPESSTKETRTD
What is the function of this protein?
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1.  Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing.  The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1.  Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.
What are the official names of this protein?
RNA 5'-monophosphate methyltransferase, BCDIN3 domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: US01_HCMVA
Sequence: MASGLGDLSVGVSSLPMRELAWRRVADDSHDLWCCCMDWKAHVEYAHPASELRPGSGGWPEHAEAQWRQQVHAAHDVWCNCGDWQGHALRSRSRTAESGRSSSSSSVSVLSDGDQQPWWRRLRVKRPKFPSWARRWTQRHDSEERASQQAENDSTS
What are the official names of this protein?
Uncharacterized protein HQLF3.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae US1 family.
Protein: RDRP_IPNVJ
Sequence: MSDIFNSPQNKASILTALMKSTTGDVEDVLIPKRFRPAKDPLDSPQAAAQFLKDNKYRILRPRAIPTMVELETDAALPRLRQMVEDGKLKDTVSVPEGTTAFYPKYYPFHKPDHDEVGTFGAPDITLLKQLTFFLLENDFPTGPETLRQVREAIATLQYGSGSYSGQLNRLLAMKGVATGRNPNKTPKTVGYTNEQLAKLLEQTLPINTPKHEDPDLRWAPSWLINYTGDLSTDKSYLPHVTIKSSAGLPYIGKTKGDTTAEALVLADSFIRDLGRAATSADPEAGVKKTITDFWYLSCGLLFPKGERYTQVDWDKKTRNIWSAPYPTHLLLSMVSTPVMNESKLNITNTQTPSLYGFSPFHGGMDRIMTIIRDSLDNDEDLVMIYADNIYILQDNTWYSIDLEKGEANCTPQHMQAMMYYLLTRGWTNEDGSPRYNPTWATFAMNVAPSMVVDSSCLLMNLQLKTYGQGSGNAFTFLNNHLMSTIVVAEWVKAGKPNPMTKEFMDLEEKTGINFKIERELKNLRETIVEAVETAPQDGYLADGSDLPPIRPGKAVELDLLGWSAIYSRQMEMFVPVLENERLIASAAYPKGLENKALARKPGAEIAYQIVRYEAIRLVGGWNNPLLETAAKHMSLDKRKRLEVKGIDVTGFLDDWNNMSEFGGDLEGITLSEPLTNQTLVDINTPLDSFDPKARPQTPRSPKKTLDEVTTAITSGTYKDPKSAVWRLLDQRTKLRVSTLRDQALALKPASSSVDNWAEATEELAQQQQLLMKANNLLKSSLTETREALETIQSDKIIAGKSNPEKNPGTAANPVVGYGEFSEKIPLTPTQKKNAKRREKQRRNQ
What is the function of this protein?
RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA.  May also contain guanylyl and methyl transferase activities (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, RDRP, Protein VP1.
What are the subcellular locations of this protein?
Virion. Note=Minor amounts are incorporated in the virion.
Protein: ISCU_MOUSE
Sequence: MAAATGAGRLRRAASALLLRSPRLPARELSAPARLYHKKVVDHYENPRNVGSLDKTSKNVGTGLVGAPACGDVMKLQIQVDEKGKIVDARFKTFGCGSAIASSSLATEWVKGKTVEEALTIKNTDIAKELCLPPVKLHCSMLAEDAIKAALADYKLKQESKKEEPEKQ
What is the function of this protein?
Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled.  The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis.  This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner.  Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly.  Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5.  Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form.  May modulate NFS1 desulfurase activity in a zinc-dependent manner.  Modulates the interaction between FXN and the cysteine desulfurase complex.
What are the official names of this protein?
Iron-sulfur cluster assembly enzyme ISCU, NifU-like N-terminal domain-containing protein, NifU-like protein.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL14_ECO55
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: PTR49_ARATH
Sequence: MVASEIKSPVSVPETPGSSSVHHRKQLSVFFIESDNRRLALGRGYTGGTTPVNIHGKPIANLSKTGGWIAAFFIFGNEMAERMAYFGLSVNMVAFMFYVMHRPFESSSNAVNNFLGISQASSVLGGFLADAYLGRYWTIAIFTTMYLVGLIGITLGASLKMFVPDQSNCGQLSLLLGNCEEAKSWQMLYLYTVLYITGFGAAGIRPCVSSFGADQFDEKSKDYKTHLDRFFNFFYLSVTLGAIIAFTLVVYVQMELGWGMAFGTLAVAMGISNALFFAGTPLYRHRLPGGSPLTRVAQVLVAAFRKRNAAFTSSEFIGLYEVPGLKSAINGSRKIPHSNDFIWLDKAALELKEDGLEPSPWKLCTVTQVEEVKILIRLIPIPTCTIMLSLVLTEYLTLSVQQAYTLNTHIQHLKLPVTCMPVFPGLSIFLILSLYYSVFVPITRRITGNPHGASQLQRVGIGLAVSIISVAWAGLFENYRRHYAIQNGFEFNFLTQMPDLTAYWLLIQYCLIGIAEVFCIVGLLEFLYEEAPDAMKSIGSAYAALAGGLGCFAATILNNIVKAATRDSDGKSWLSQNINTGRFDCLYWLLTLLSFLNFCVFLWSAHRYKYRAIESEEDKSSAVL
What are the official names of this protein?
Protein NRT1/ PTR FAMILY 6.1, AtNPF6.1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AROA_PSES2
Sequence: MSHSASPKPATARRSEALTGEIRIPGDKSISHRSFMFGGLASGETRITGLLEGEDVINTGRAMQAMGAKIRKEGDVWIINGVGNGCLLQPEAALDFGNAGTGARLTMGLVGTYDMKTSFIGDASLSKRPMGRVLNPLREMGVQVEAADGDRMPLTLIGPKTANPITYRVPMASAQVKSAVLLAGLNTPGVTTVIEPVMTRDHTEKMLQGFGADLTVETDKDGVRHIRITGQGKLVGQTIDVPGDPSSTAFPLVAALLVEGSDVTIRNVLMNPTRTGLILTLQEMGADIEVLNARLAGGEDVADLRVRASKLKGVVVPPERAPSMIDEYPVLAIAASFAEGETVMDGLDELRVKESDRLAAVARGLEANGVDCTEGEMSLTVRGRPDGKGLGGGTVATHLDHRIAMSFLVMGLAAEKPVTVDDSNMIATSFPEFMDMMPGLGAKIELSIL
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_BORPD
Sequence: MPEETLLAFDFGEKKIGIAIGNTLTRQARPLEIIFSEIREARFARIGQLLQQWQPQRVVVGLALASDGGEQPATARCRRFANQLRGRYGLAVELVDERGSSMEAQRLLGTHAPDDAVAAAVILQRYLDALP
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_HYPNA
Sequence: MAKKSAIEKNNRRKALAARYAAKRAQLKAAAMDENLSLEERFKARLKLAELPRNSAPNRVRNRCEITGRPRAFYRKLKMSRIALREYGSRGQVPGLVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: ATPL_LACPL
Sequence: MGAIAAGIAMFGAALGAGIGNGLVISKMLEGMARQPELSGQLRTNMFIGVGLIESMPIISFVVALMVMNK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS1_MYCBO
Sequence: MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRPKDIAIYVGSGELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNWTTADLAGMRIATAYPNLVRKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGRTLSQHDLVAFGEPLCDSEAVLIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIAPLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRFCRF
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.