PharMolix/UniProtQA huggingface dataset:
Protein: COX2_DESAU
Sequence: MAYPMQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYLISLMLTTKLIHTNTMDAQEVETIWTILPAIILVLIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNELKPGELRLLEVDNRVILPIELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGIFYGQCSEICGSNHSFMPIVLEMIPLKFFENWSSSMT
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BAT39_CAEBR
Sequence: MSLLQPMRDMAAKMKTLCFKIMNFEHLDGSYTSESKLENGGHWAVRFVSSKTAKSTKRRLSVYLVCFPATDNPEWSISTSFAFRFLNSWGNSKTKISPLCTHTFTAKDNSKGASGFCAWDDIVTPNSGFLVNGVFTIEFDLSISRTTGYQIEKKDHTSFLADGKLIVEDQTIDVCLALLADNSPVLYDMIYNENPGQTEFEIFDFTYDSILGMVSILQLDEFKVNVRNYRDLLELGQRYQIVAVMDQCEEFLLRTKKVSIETKLKLSETFQLHFLQFRTIERIQCMERLEAILDENIDIEDKTYEALLEKMKQLKSQEEKESCSCKKKHCGRSRV
What are the official names of this protein?
BTB and MATH domain-containing protein 39.
Protein: HSLO_PROMP
Sequence: MGDKIVRATAANGGIRLVAVLTTDSSMEAKERHGLSYLTTSILGRAFSASLLLASSMKVMHGRVTLRVRSDGPLKGLLVDAGRDGKVRGYVGNPNLELDLVKTKQNQYSFDFTKALGTGYLNVIRDNGFGEPFTSTVELVNGNIAEDLASYLYHSEQTPSAVFIGEKIQNKNIISSGGLLAQVLPKKETDPLLVSLLEERCKEINSFSEDLFKSKDNLLSLIKNIFPDIDDKSISEKARTQEVRFECRCSRQRSLNAMKMLDKNELKDILIKEGKAELVCEFCKNKYLINSEEIKEMIKN
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y255_RICFE
Sequence: MKKLLLIIITVFFAFNVAQASLPNIVASVNYEPITLNEFRARKKMIMALNNVESLTPAQDKQLSDLAIKSLIDESLLFQYAGDREIPQEEIDNAIKSIEDHNKMPHGSLLQYLKSRSVNPDSFISQIKSELIKMNILSSLSRSVQVSNKEIDVAILSSDQKDVEISMQVFTSKDGGNKAFTQMNNLKNRLKKCADVKKSLYDNFATMQIITDKLSKIEGVKQTIVKDLSSDKASNVFEVNNKFEIILVCSKKILNVNEDENNYVVNFLTNKKISQKAQKMFENMRKKAVIKIMLPS
What are the official names of this protein?
Uncharacterized protein RF_0255.
Protein: ILVC_SLAES
Sequence: MSVKTKEKEMAVTILYEQDVDPKVIQGLKVGIIGYGSQGHAHALNLMDSGVDVRVGLREGSSSWKTAEEAGLKVTDMDTAAEEADVIMVLVPDEIQPKVYQEHIAAHLKAGNTLAFAHGFNIHYGYIVPPEDVNVIMCAPKGPGHIVRRQFTEGSGVPDLACVQQDATGNAWDIVLSYCWGVGGARSGIIKATFAEETEEDLFGEQAVLCGGLVELVKAGFETLTEAGYPPELAYFECYHEMKMIVDLMYESGIHFMNYSISNTAEYGEYYAGPKVINEQSREAMKEILKRIQDGSFAQEFVDDCNNGHKRLLEQREAINTHPIETTGAQIRSMFSWIKKED
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: J_BPAL3
Sequence: MKKARRSPSRRKGARLWYVGGSQF
What is the function of this protein?
Mediates ssDNA packaging into virion, it locates to the internal surface of the capsid, thereby displacing the internal scaffolding protein B during virion formation.  Protein J binds to and is packaged with the viral ssDNA.  Additionally, protein J plays a role in viral attachment efficiency to the host cell.
What are the official names of this protein?
DNA-binding protein J, J protein, Small core protein.
What is the protein family that this protein belongs to?
Belongs to the microviridae J protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=situated at the interface between the internal surface of the capsid and the nucleic acid.
Protein: MUG_KLEP3
Sequence: MISDILAPGLRVVFCGINPGKSSAHTGFHFAHPGNRFWKVIHQAGFTDRQLRPEEELQLLDTRCGITMLVERPTVQASEVALQELRSGGRELVRKIEEYQPQALAVLGKQAFELAFNQRGAKWGKQAITIGTTQVWVLPNPSGLNRATLDKLVAAYRELDDALATRGQ
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_BORBZ
Sequence: MKIAVLLSGGVDSSVALYRIINKGYSNIKCYYLKIWVEDELSYIGNCPWQEDLNYVEAICNKFNVPYEIINFQKEYYNKVVSYTIEELKNGNTPSPDIFCNQRIKFGAFFEKINSQYDLVVTGHYAKIQIKESKFLLKQAKDKIKDQSYFLSHLSQKQISKLYFPLGTLLKSEVRQIAKNINLPNKDRKDSQGICFLGKIKYNEFIKYHLGEKKGNIIEKETGKIIGIHNGYWFFTVGQRRGIKLSNGPWFVIEKDLEKNIIYISHNENYLKQAKRKFLVHEIHWINDTPTNFENFKIKIRHGEKKYSCKLKLITNNLMEISLNKKDQGISPGQFAIFYKNTECLGGAKIFKIIE
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_PROA2
Sequence: MTIKTIEGTLDARNSRFALVVSRFNDFIGQKLVEGAVDCIVRHGGSEEQIALYKCPGAFELPSVAKKVAVSGRYDAVITLGAIIRGATSHYDVIAAEATKGVAQVGLDTMIPVTFGVLTTDNLEQAIERAGTKAGNKGFDAALAAIEMVNLYQQV
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: CLML_MESEU
Sequence: MSTFIVVFLLLTAILCHAEHAIDETARGCNRLNKKCNSDADCCRYGERCISTGVNYYCRPDFGP
What is the function of this protein?
Voltage-gated potassium channel (Kv) inhibitor (Ref. 2).  In addition it may increase intracellular calcium release through the activation of nuclear inositol 1,4,5-trisphosphate receptors (ITPR) of cardiomyocytes, thereby causing an increase in the contraction frequency of these cells (By similarity).
What are the official names of this protein?
Neurotoxin lambda-MeuTx, Calcium channel toxin-like peptide-1.
What is the protein family that this protein belongs to?
Belongs to the scorpion calcin-like family.
Protein: ISPT_NEIG1
Sequence: MKSSTQTILEHTAIPRHIAVIMDGNGRWAKKRFLPRIMGHKRGLDALENMVKHCAKLGVQYLTVFAFSTENWRRPEDEVSFLMGLFLQALQKQVRRLHENNMRLKILGSRERFNRQILQGIEEAEALTANNTGLTLSIAADYGGRWDILQAANKLIAEGVSEITEDTLAKHLMLGDAPEPDLFIRTGGETRISNFLLWQMAYAELYFTDILWPDFDETALDAAVASFQKRERRFGRTSEQLPIGQQRN
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: ANGL6_HUMAN
Sequence: MGKPWLRALQLLLLLGASWARAGAPRCTYTFVLPPQKFTGAVCWSGPASTRATPEAANASELAALRMRVGRHEELLRELQRLAAADGAVAGEVRALRKESRGLSARLGQLRAQLQHEAGPGAGPGADLGAEPAAALALLGERVLNASAEAQRAAARFHQLDVKFRELAQLVTQQSSLIARLERLCPGGAGGQQQVLPPPPLVPVVPVRLVGSTSDTSRMLDPAPEPQRDQTQRQQEPMASPMPAGHPAVPTKPVGPWQDCAEARQAGHEQSGVYELRVGRHVVSVWCEQQLEGGGWTVIQRRQDGSVNFFTTWQHYKAGFGRPDGEYWLGLEPVYQLTSRGDHELLVLLEDWGGRGARAHYDGFSLEPESDHYRLRLGQYHGDAGDSLSWHNDKPFSTVDRDRDSYSGNCALYQRGGWWYHACAHSNLNGVWHHGGHYRSRYQDGVYWAEFRGGAYSLRKAAMLIRPLKL
What is the function of this protein?
May play a role in the wound healing process.  May promote epidermal proliferation, remodeling and regeneration.  May promote the chemotactic activity of endothelial cells and induce neovascularization.  May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
What are the official names of this protein?
Angiopoietin-related protein 6, Angiopoietin-like protein 6, Angiopoietin-related growth factor, Angiopoietin-related protein 5.
What are the subcellular locations of this protein?
Secreted.
Protein: RL32_DESVM
Sequence: MAVQQNKKSKSKKGMRRSHDRVAVPTIVYCACGEPTVPHRACPSCGTYKGRQVVAQPNE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: FAR17_LUCCU
Sequence: PDNFMRF
What are the official names of this protein?
FMRFamide-17, LucFMRFamide-17.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CARB_XYLFT
Sequence: MPKRTDLRTILIIGAGPIVIGQACEFDYSGAQACKALRAEGFRVVLVNSNPATIMTDPDMADAVYIEPIHWRTVEKIITKEKPDALLPTMGGQTALNCALDLADHGVLEKYGVELIGAKREAIRMAEDRELFRVAMQEIGLECPKAEVAKSLERALEIQAKVGFPTIIRPSFTLGGTGGGIAYNRQEFEEIIKRGLELSPVHEVLVEESVLGWKEFEMEVVRDASDNCIIVCSIENLDPMGVHTGDSITVAPAQTLSDKEYQRLRDASIAVLRKIGVDTGGSNVQFGIDPQTGRVVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDELKNEITGGKTPASFEPSIDYVVTKIPRFAFEKFPQADARLTTQMKSVGEVMAMGRTFAESLQKAVRGLETGKVGLEPTGLDLSSEDDLVVLKRELKAPGAERLFYVADAFRAGFAVADVYALSYIDPWFLDQIEEIVAAEGRLVTDGLGSIDGARLRQLKRIGFSDARIAQLTGTNEVAVRTLRRVLKVKPVYKRVDSCAGEFATGTAYLYSTYEEECEAAPSDRRKIMILGGGPNRIGQGIEFDYCCVHAALALREDGFETIMVNCNPETVSTDYDTSDRLYFEPLTLEDVLEIVEVEHPVGVIVQYGGQTPLKLAKALEANGVPVIGTSPESIDLAEDRERFQRLVQQLGLRQPPNCTARTADEALVLAREIGYPLVVRPSYVLGGRAMEIVYSEADLARYVRDAVKVSNDSPVLLDRFLDNAVEVDVDIIADPEGQVLIGGVMEHIEEAGVHSGDSSCSLPPYSLSAATQDDLRRQVIRLAQALNVIGLMNTQFAIQSNDDGSDIVYLLEVNPRASRTVPFVSKATGVPLAKIAARCMTGKTLAEQSVTCEVVPAYYAVKEAIFPFAKLQGVDPILGPEMRSTGEVMGVGRSFAAAFARAQEAGDIRAPQPGRAFVSVRDPDKKRVLPVVLALVERGFGVVATAGTYAWLQQNGVACEVVNKVAEGRPHIVDLIKNGEIVYIINTTEGRAAIADSFSIRREALQHCVTYSTTIAGAKALVNSLEFRGTGPVWSLQELHKELQV
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: GLNE_ECO5E
Sequence: MKPLSSPLQQYWQTIVERLPEPLAEESLSAQAKSVLTFSDFVQDSISAHPEWLTELESQPPQADEWQHYVAWLQEALINVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRWELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLLRITALLAGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSTEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVPEDCFTAERELVRASWQKWLVEE
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: HTRAL_STAAC
Sequence: MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKHERFKNSLSSHLEQRNRDVNENKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDTEKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHEEQHVLSKPSEHDKETRIDSESSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPEEQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHIPSISDDKDNVMRENHIVDDNPDNDINTPSLSKTDDDRKLDEKIHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDHDKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILKKFWMMYWPKLVILMGIIILIVILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKASQDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKATSSDSSVKEIAIGDSNNLVLGEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNKYDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISMPNVENMSFAIPVNEVQKIVKDLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKGDVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK
What are the official names of this protein?
Serine protease HtrA-like.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: DTD_SALHS
Sequence: MIALIQRVTRASVTVEDEVTGEIGPGLLVLLGVEKEDDEQKANRLCERVLGYRIFSDADGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSGGAAPDRAQALYEYFVERCRQQAINTQTGRFAADMQVELVNDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFP_ORYSJ
Sequence: MAGAIRVTMEVGADGVAVVTICNPPVNALHPIIIQGLKEKYAEAMDRDDVKAIVLTGAGGKFCGGFDINVFTEVHKTGNVSLMPDVSVELVSNLMEAGKKPSVAAIQGLALGGGLELTMGCHARISTPEAQLGLPELTLGIIPGFGGTQRLPRLVGLPKAIEMMLQSKFITAKEGKEGGLVDALCSPDELIKMSRLWALEIANYRKPWIRSLARTDRLGSLSEARSVLNSARQQAKKVAANLPQHQACLDVMEEGVLCGGHAGVLKEAKVFKELVLSPTSKALVHAFFAQRLTTKVPGVTDVQLKPRKIRKVAVIGGGLMGSGIATALLVSNTSVVLKEVNPQFLQRGQKMIAANLEGLVKRGSLTKDKMNKAMSLLKGALDYSDFKDVDMVIEAVIEKIPLKQSIFSDLEKVCPPHCILATNTSTIDLNVVGEKTNSQDRIIGAHFFSPAHIMPLLEIVRTEKTSPQAILDLITVGKMIKKVPVVVGNCTGFAVNRTFFPYTQGSHLLVSIGIDVFRIDRVISSFGMPMGPFQLQDLAGYGVALAVKDIYAAAFGTRNLDSNLVDLMVQNGRQGKSNGKGYYLYEKGGKPKPDPSVQVVIDEYRRCAKTMPGGKPVTLSDQDILEMIFFPVVNEACRVMDENVVIRASDLDIASILGMGFPKFRGGLVFWADTIGAPYIHSKLSKWTEIYGDFFKPSSYLEDRAKRSLPLSAPNATQQASSRSRM
What is the function of this protein?
Multifunctional enzyme involved in fatty acid beta-oxidation.  Also binds to RNA and microtubules.  Possible role in subcellular mRNA localization and RNA-cytoskeleton interactions.
What are the official names of this protein?
Peroxisomal fatty acid beta-oxidation multifunctional protein, MFP.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Peroxisome. Cytoplasm, cytoskeleton.
Protein: GMHBA_CAMJE
Sequence: MKTKALFLDRDGVINIDKKYVYKIEDFEFCDGIFELCRYFLARNYLLFIATNQSGIARGYYKESDFFKLCDYMLKEFAKQDIKIDKIYHCPHLEGCECRKPKAGMLLKAKDEFDLDMKNSIFIGDNLSDMQAGLNADIGTLILVNEEKKEGDFFRQFKNLKEILNFFKEKDI
What is the function of this protein?
Converts the D-glycero-alpha-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
What are the official names of this protein?
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase, D,D-heptose 1,7-bisphosphate phosphatase, HBP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the GmhB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMF_SHIBS
Sequence: MSAQKPGLHPRNRHHSRYDLATLCQVNPELRQFLTLTPAGEQSVDFANPLAVKALNKALLAHFYAVANWDIPDGFLCPPVPGRADYIHHLADLLAEASGTIPANASILDIGVGANCIYPLIGVHEYGWRFTGSETSSQALSSAQAIISANPGLNRAIRLRRQKESGAIFNGIIHKNEQYDATLCNPPFHDSAAAARAGSERKRRNLGLNKDDALNFGGQQQELWCEGGEVAFIKKMIEESKGFAKQVMWFTSLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMNDEQRRRFVNRQR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBCX_SYNE7
Sequence: MASTQRAKPMEMPRISRDTARMLVNYLTYQAVCVIRDQLAETNPAGAYRLQVFSAEFSFQDGEAYLAALLNHDRELGLRVMTVREHLAEHILDYLPEMTIAQIQEANINHRRALLERLTGLGAEPSLPETEVSDRPSDSATPDDASNASHAD
What is the function of this protein?
Improves functional assembly of RuBisCO upon coexpression in E. coli with the large and small subunits of RuBisCO (rbcL and rbcS), however it is not essential in vivo (PubMed:17071623).
What are the official names of this protein?
RuBisCO chaperone RbcX.
What is the protein family that this protein belongs to?
Belongs to the RbcX family.
What are the subcellular locations of this protein?
Carboxysome. Cytoplasm. Note=Most protein is cytoplasmic, but some is in the carboxysome.
Protein: SNAI1_HUMAN
Sequence: MPRSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLIWDSVLAPQAQPIAWASLRLQESPRVAELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSVSSLEAEAYAAFPGLGQVPKQLAQLSEAKDLQARKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKHQESGCSGCPR
What is the function of this protein?
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration.  Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920).  The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412).  During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity).  SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity).  Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3.  In addition, may also activate the CDKN2B promoter by itself.
What are the official names of this protein?
Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna.
What is the protein family that this protein belongs to?
Belongs to the snail C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
Protein: RTN2_YEAST
Sequence: MNRNTTTNKNANLNNSRNANAPGEAGHQNKTGLIYWTNPSKSGASFAATLVSLLILRNVNVISVLLKIGYMVLFTSFAVELSTKVLFDKGVVSRFGMQESPDLVGVLKPHIDRELDRLPALEDRIRKLVFAHRTRNNFTIGVSLYFLHGLFAIFSMNTVLIMTTIFLYTVPLIYDRKQARIDRAIDRMKDLVIHRFHKNYNKVVEKTEPYIDKIIPPQTDEGSYSTSISNENKSSTSQRNKSGLSSSEFDNMNDTSASKSGKDSYSTSQYNRAEYPVSQNENIGTLKSGKQEIPTEKDFNNRHENFSKPDVKTYDPRTVDIEEELAAHQRELEQNLKDGDYNLVGSKEIPDPITVPAPTRHTTKPAESQSIPIKNNETLHKTTHGLKQKLQHA
What are the official names of this protein?
Reticulon-like protein 2.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL5_STAES
Sequence: MNRLKEKFNTEVTENLVKKFNYSSVMEVPKIEKIVVNMGVGDAVQNSKVLDNAVEELELITGQKPLVTKAKKSVATFRLREGMPIGAKVTLRGERMYEFLDKLIAVSLPRVRDFQGVSKTAFDGRGNYTLGVKEQLIFPEIDYDKVTKVRGMDIVIVTTANTDEEARELLTNFGMPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: Y1369_METJA
Sequence: MRDIVMTYWLFSSNNIRNIEICYNHMIWGFWDRNAGEKQKKNWRSFIRKYNQIKPFDVAVFQIAKTGEIHAIGVIKETYYDDQTPIWDNEINLNKVTFPWRVSFSVIIFSKEAVIKRFIKIQDYIDGYGLGELEHHDFNEILKAFQKKFGMISIK
What are the official names of this protein?
Uncharacterized protein MJ1369.
Protein: HUTH_PSYIN
Sequence: MYELHIKPGQLTLSQLRKISRHALKVSLESSCIEAIHASTQVVNQVIAENRVAYGINTGFGLLANTRIAPEDLETLQRSIVLSHAAGIGELMNDETVRMMMVLKINSLARGFSGIRLSVIEALMTLVNAQIYPCVPKKGSVGASGDLAPLAHMSTVLLGEGEARYQGNIISGAKALEIAGMQPITLAPKEGLALLNGTQASCAFGLEGLFAAEDLFASATLCGAMTVDAALGSRRPFDDRVHQVRGHQSQIDSALIYRHILDTHSEVSHSHTACEKVQDPYSLRCQPQVMGACLQQIRNSAAIYEIEANSVSDNPLVFAEDGDIISAGNFHAEPIAMASDNLALAIAEIGSLSERRMALLIDNSLSKLPPFLVNNGGVNSGFMIAQVTAAALASENKSLAHPACVDSLPTSANQEDHVSMATFAGRRLKEMAENTRGILAVELLAAAQGLDFRSPLKSSELIETAKAELRERVDFYDKDRYFAPDIKQANQLLIEAMHNKLIPEGLLPSL
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.