PharMolix/UniProtQA huggingface dataset:
Protein: COX2_ANIIM
Sequence: MAYPFQLGLQDATSPIMEELTSFHDHTLMIVFLISSLVLYIILLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPALTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKHFENWSASMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SCNM1_MOUSE
Sequence: MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQTGKGTEQNPRQQNELKTESKTEAPLLTQTRIITQNALHRAPHYNSCCRRKHRPEAPAPSVSSPPLPTAEVQLQSAEISKEPEPRERSDAKESAALLASAPMSPTKRRVLNHYLTLRSSGWVPDGRGRWIKDENVEFDSDEEEPPDLPLD
What is the function of this protein?
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:17656373, PubMed:12920299).  Plays a role in the regulation of primary cilia length and Hedgehog signaling (By similarity).
What are the official names of this protein?
Sodium channel modifier 1.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus speckle. Note=Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles.
Protein: HSLU_MARSD
Sequence: MSNLTPREIVSELDKFIIGQSDAKRMVAIAMRNRWRRQQLPPELRDEIAPKNIIMMGPTGVGKTEIARRLAKLAGCPFFKVEATKFTEVGYVGRDVESMVRDLMEIGINLVRKEEMEKVKVKAEKHAEDALLDILLPSSKPKQPGMGFFNPAAPEEQEEQPSADQSSTREKFRKMWREGKLDDREVEIEVSVQGGGVEIMSMPGMEDMGMQVNDMIGKMFPNKKKMRKVKIREAYDILIQQESDKLIDMDNVAELARERVEQGGILFLDEIDKIAGNQEGGGSANVSREGVQRDLLPVVEGCVVNTKYGMVKTDHILFISAGAFSYAKPSDLIPELQGRFPLRVELTSLDKDDFYRILTEPQNALTVQYKALLETENLNIDFSREALEEVALNAQKFNEETENIGARRLYTIMEKILSDLSFEAPDRSGDSIVIDKEYVQKQLQDVTEDRDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_MYCBO
Sequence: MSSTVLVINSGSSSLKFQLVEPVAGMSRAAGIVERIGERSSPVADHAQALHRAFKMLAEDGIDLQTCGLVAVGHRVVHGGTEFHQPTLLDDTVIGKLEELSALAPLHNPPAVLGIKVARRLLANVAHVAVFDTAFFHDLPPAAATYAIDRDVADRWHIRRYGFHGTSHQYVSERAAAFLGRPLDGLNQIVLHLGNGASASAIARGRPVETSMGLTPLEGLVMGTRSGDLDPGVISYLWRTARMGVEDIESMLNHRSGMLGLAGERDFRRLRLVIETGDRSAQLAYEVFIHRLRKYLGAYLAVLGHTDVVSFTAGIGENDAAVRRDALAGLQGLGIALDQDRNLGPGHGARRISSDDSPIAVLVVPTNEELAIARDCLRVLGGRRA
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCS_PSEPF
Sequence: MKLPIYLDYSATTPVDPRVAQKMSECLLVDGNFGNPASRSHVFGWKAEESVENARRQVADLVNADPREIVWTSGATESDNLAIKGAAHFYASKGKHLITSKIEHKAVLDTMRQLEREGFEVTYLDPTEDGLITPAMIEAALREDTILVSVMHVNNEIGTVNDIAAIGELLRSKGILFHVDAAQSTGKVEIDLQKLKVDMMSFSAHKTYGPKGIGALYVSRKPRVRIEATMHGGGHERGMRSGTLATHQIVGMGEAFRVAKEDMAAENVRIKALSDRFYKQVEHLEELYVNGSLTARVPHNLNLSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTFGRFTTEEEIDYAAQKVCEAVTKLRALSPLWDMYKDGVDISKIEWAAH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_STRCO
Sequence: MFNDIGALELVTLVVLAVLVFGPDKLPKVIQDVTRTIRKIREFSDSAKQDIRQELGPEFKDFEFEDLNPKTFIRKQLDNEELGLKEIRNGFDLKKEMAEVTDAVHGRDAESSSSGSSSGSSSAASGNGRVDMSKKPEKPEKPGKTDKPAADDRPPFDMDAT
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: KAD_NOVAD
Sequence: MNIILLGPPGAGKGTQAQRLVERHGMKQLSTGDMLRAAVKAETPVGLKAKAVMEAGQLVSDEIVSALIGDELDAMPAGQGAIFDGYPRTAPQAESLDAILESRGRKLDHVIELDVNEDALVERITGRYTCATCGKGYHDKFEKPAVEGTCDKCGGHEFKRRPDDNEETVRTRMAEYRAKTAPILPIYESRGIVSRVDGMADMDDVTAAIEAILAAR
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_SYNJA
Sequence: MSGVTYRVTGINLKAMPLGEADRIITILTREQGLIRAVAKGSRKQLSKWGGRMEPFVVNDLLVARGRWSAQTDPSQCLQRIAQAETLQSFPRLGRSLAHLTAAQYLAEVALLLALPNQPQEELFVLLVEHLERIEQAPATEAVLPLLVHGLYHLLVVGGVAPSVQACYSCGEELAGEAFFSPHAGGLVCDPCRLAQRLSPVAWVSSSVLQALGSLPNPTLPSLAERALPLASWLAAERLLRRVLELHADRAIRSAGLLASCYSVPVAETLPPTPSGQGSPVAAAAFSEEDSETLGSNLKKL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: PSB9_MUSTR
Sequence: MLRAGAPTAGSFRTEEVHTGTTIMAVEFDGGVVVGSDSRVSAGAAVVNRVFDKLSPLHQRIFCALSGSAADAQAIADMAAYQLELHGLELEEPPLVLAAANVVKNISYKYREDLLAHLIVAGWDQREGGQVYGTMGGMLIRQPFTIGGSGSSYIYGYVDAAYKPGMTPEECRRFTTNAITLAMNRDGSSGGVIYLVTITAAGVDHRVILGDELPKFYGE
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.  This subunit is involved in antigen processing to generate class I binding peptides.
What are the official names of this protein?
Proteasome subunit beta type-9, Low molecular mass protein 2, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, Proteasome chain 7, Proteasome subunit beta-1i, Really interesting new gene 12 protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NAC_PYRAB
Sequence: MMPMNPKQLKKLMKQLDMKQLDGVKEVIIKLENKEIVIKEPVVTVIRAMGEKMYQIAGGTEEERVVLKISEEDIKLVMEQAGVDYETAKKALEEAGGDLAEAILRLTDQ
What is the function of this protein?
Contacts the emerging nascent chain on the ribosome.
What are the official names of this protein?
Nascent polypeptide-associated complex protein.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: HIS4_NITHX
Sequence: MILFPAIDLKDGQCVRLEQGDMARATVFNFDPAEQARAFASQGFEYLHVVDLDGAFAGRPVNADAVERMLKNVAMPVQLGGGIRDLKTVEAWLKKGITRVIIGTAAVRDPVLVKEAAKAFPGRVAVGLDARDGKVAVEGWAETSEVTALDIARRFEDAGIAAIIFTDIARDGLLKGLNLDATIALADSISIPVIASGGFASIADVKALLAPRAKKLAGAIAGRALYDGRLDPAEALALIRAARAAA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_PHOPR
Sequence: MTAKFIVIEGLEGAGKSTAIQQVIDALAAHGIENPESTREPGGTPLAEQMRALIKEGHPDEPLTDMAELLLLYAARIQLVDNIIKPALAEGRWVVGDRHDMSSQAYQGGGRGFDKALMENLRDTVLGDFCPDLTIYMDIDPILGLERARGRGELDRIEKMNVDFFHRARARFLELSENNPKVIIIDAGQSLENVTSDLKQALNHWLEKQ
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: MED18_BOVIN
Sequence: MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFVDHEMVFLLKGQQASPFVLRARRSLDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLMEMGFRMDHEFVARGHLFRKGIMKIVVYKIFRILVPGNTDNTEALSLSYLVELSVVAPAGQDMVSDDMRNFAEQLKPLVHLEKIDPKRLM
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 18, Mediator complex subunit 18.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMO_PSEE4
Sequence: MSTTPATPKVGFVSLGCPKALVDSERILTQLRMEGYEVVPTYEDADVVVVNTCGFIDSAKAESLEVIGEAIKENGKVIVTGCMGVEEGSIRDVHPSVLSVTGPQQYEQVVNAVHEVVPPRQDHNPLIDLVPPQGVKLTPRHYAYLKISEGCNHSCSFCIIPSMRGKLVSRPVGEVLSEAERLVKAGVKEILVISQDTSAYGVDVKYKTDFWNGRPVKTRMLELCEALSSLGAWVRLHYVYPYPNVDDVIPLMAAGKILPYLDIPFQHASPKVLKSMKRPAFEDRTLARIKNWREQCPELVIRSTFIVGFPGETEEDFQYLLDWLTEAQLDRVGCFQYSPVEGAPANDLGLDEVPDDVKQERWDRFMAHQQAISAARLQQRIGKEIEVLIDEVEEQGSVGRSFFDAPEIDGSVFIDGDHGFKPGDKVRCRIVDADEYDMWAEPI
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM1_METJA
Sequence: MILKEGEVVFEVPDKLTVTKKDEVFYNPRMKTCRDISIAVIQAFLNLYHKRDKFYIADALAGSGIRGLRYAKELEFNGELKVFLNDINPKAYEKIINNAKLNEIENIDVFNEDANTFLSKHFRFFNVVDIDPFGSPAPYVEQAIRALVTRNGLLCLTATDTAALCGRSKKSCLRKYLAYPLFGRDCHEFALRVLVGYVMRMATKYELALKPVFCHATDHYVRVYLVTDRGAKRADKVFEMLGYVKDVNGIKIIKKFEEGYEKGFAGPLYIGNLYDKALVEEALKIAEKREFSERVLKILNAIKGESAINQVGCYDTHQIGKMLKISVPPMQDIINKLKEMGFNAVVTHYNPKGIKTDATLKNVIEAIYQCTKIR
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: MYFA_YEREN
Sequence: MNMKKFVKKPLAIAVLMLASGGMVNMVHAEPTVINSKDISATKTVKEGGSFSVEFKATENEIVSGKLDADTPAFHLVMSDSGEHKGWNVRPTGASEGGQMVSADGTRVDLHTNELSWDNDHWWIDDGSERVEATFFLAAGDEVKAGEYQFTGRVEEYVE
What is the function of this protein?
Major pilus subunit.  Expressed only in pathogenic serotypes, it is part of myf, a probable virulence factor.
What are the official names of this protein?
Fimbrial protein MyfA, C-AG, Myf antigen.
What are the subcellular locations of this protein?
Fimbrium.
Protein: HOG1_ASPGL
Sequence: MAEFVRATIFGTTFEITSRYTELQPVGMGAFGLVCAARDQLTGAPVAVKKIMKPFSTPVLSKRTYRELKLLKHLGHENIICLSDIFISPLEDIYSVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICGFGLARVQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLDGKPLFPGKDHVNQFSIITELLGTPPDDVIETICSENTLRFVKSLPKRERQPLTSRFKNADPEAVDLLERMLVFDPKKRIRAGEALAHEYLAPYHDPTDEPEAQEKFDWSFNDADLPVDTWRIMMYSEILDFHNIDQSEDAGQVLVEGVGDGQQAFAA
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase hog1, MAP kinase hog1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HBA1_TADBR
Sequence: VLSPEDKNNVKAAWSKVGGQAGDYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVGEALTTAVNHMDDLPGALSTLSDLHAYKLRVDPVNFKLLSHCLLVTLACHNPGEFTPAVHASLDKFLASVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1, Alpha-1-globin, Hemoglobin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: GCYA2_HUMAN
Sequence: MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL
What is the function of this protein?
Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.
What are the official names of this protein?
Guanylate cyclase soluble subunit alpha-2, GCS-alpha-2.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_NOSP7
Sequence: MASIIQALPTEVVYLITAGEVIDSLASVVRELVENSLDAGATRIVVSLWPQQWRIRVADNGCGMNLDDLQQAATAHSTSKIRSSADLWKINSLGFRGEALHSLTTLADLEILSRPVDGKLGWRISYGNGGKVVQVEVTAIAPGTVVTVSNLFGNCSSRRQGLPTTAQQMKAVQATIYQIALCHPHVTWQIWQNDRQWFTISPARTTGQLLPQILPQVRQGDLQEVKLEIPNPPHSPLPCTNAIHRVSPHSALTLVVGLPDRCHRHRPDWVRVAINGRMVKTPELEQTILSAFHRTLPRDRYPICFLHLAISPDQINWNRNPAKTEIYLNEIIYWQEQITQAINQALSISSSNLKEAVHTTRVSKLLKAAEAKGGYNFNPQNPKEDRKNPNSLKAVAQVSNTYIVAEHPGGMWLVEQHIAHERVLYEQLCDDWQLVPVEPPIILYQLSLAQVSQLQRIGLDIESFGEQLWAVRNIPAPLQQRDDCAEAILELSWGGDLQTAQVAVACRSAIRNGTPMNQQEMQTLLDNWQRTRNPRTCPHGRPIYLSLEESALARFFRRNWVIGKSHGI
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: ARRD4_HUMAN
Sequence: MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSTCPRASASTAALAVFSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPPYPQPPNCEGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPVSFIL
What is the function of this protein?
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity).  Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable).  Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity).  May play a role in glucose uptake (PubMed:19605364).  Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (PubMed:28594402).
What are the official names of this protein?
Arrestin domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
What are the subcellular locations of this protein?
Early endosome. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Note=Also found in extracellular vesicles different from exosomes.
Protein: MPGS_AERPE
Sequence: MMLSLPAKFEVFGAVRIYDVSRVLSLDGRPKSRPTNLVYVDRGELEDAAFRTVIVVPVKDEDLLTLENVLRSIPTESPVVVVSASTREPVDRFSNEVELARLISRSLQRDIAIVYQFDPAWSEALSGTPLESMVGASGRVRKGKGEGMLLGFIVAAALGADFVGYVDSDNYVPGSALEYSWIYYSALSRATSSYSMVRIVWPYKGKLAASDMYLRKRGRVSTITNGVLNYTLSIYKRIETDIIKTGNSGEQALTVKLGMEMNWGSGFAVETYQLVWMLENCYLGLQAGKCPIAPDYIEVRQVSPLNPHIHAERGDEHIAEMTAVSLGTIFHSSLASEEVKSRILDQLKSLGLAEEPPKPSTYRPAGTDPKKVFASFIAESSDSYYFAV
What is the function of this protein?
Transfers a mannosyl group from GDP-mannose to phosphoglycerate to form mannosyl-3-phosphoglycerate (MPG).
What are the official names of this protein?
Mannosyl-3-phosphoglycerate synthase, MPG synthase, MPGS.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCY14_CAEEL
Sequence: MCLFLLLFPYLASGQFLQTVKVGLLFSKDTASVMRAVGYRTSAAAVLVARDRIRAEHLLDQYDFNFTVKFDECTEGLAGGKTVELINHDNVDVIIGPTCNRAGIAVASLAAYYNVPVFQWGLTTAADIGNVSRYPTTVTLSLDTHSMALGVREVLRRFEWDEFVFIYSNDGDEEKCASMKDDLEKMGIENSDVTLAYMVQIQTVTLDALQKALTEVSKRGRIIIACFANGRGFKKAFVASTVLAGMSTDEYMYMFAEPQSRGFYVDEINGGEHYSWDDTDGNFVTGLTPEQIRDAYGKVLYICDNMGLPTTITPEFANFSSQLISRMTEQPFNCVQDCSNSTYKVPATYAGQLFDAFYAYGVALNRSLTQDPTRANLKNGSFVLSDIGMSFQGVGGGTVTLDDTGTRIVQVYMFALNTSLLPYLAASLVINGSEVEYTPFYKSEADLWSVRPLARPICGFSGLECPPDFVKEYLVYTIIAAVIVVLALLAGCAGLLYTMQMKRKEMERQDLLWQVPFIELQQVQSKSKAEASMHSFASGPSTSTKITVESRSETINFIFYYYQQDILAAMKHDLILQFDAEQKAEFRQMRNFDNDNLNKFIGLCLDGPQLFSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISNGLLFIHNSFLKCHGHLTSRCCLIDDRWQIKISGYGLKSVRTFENPKKEDLLWTPPENLRNENEERLPEGDIYSFGIICSEILTRSSAFDLENRKEKPDVIIYQVKKGGHNPMRPSLDTGETVEINPALLHLIRDCWTERPSERPSIEQVRGHLNGMRDGRKSNLMDHVFNMLETYASTLEEEVSDRTKELVEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNEHIRHIARMSLGFLSSLEFFRVQHLPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVGGFRTESRGEVIIKGKGVMETYWLLGEQSRISVSAQAPREKTPEPPRRQSVRSISPIIEKMSEETQKGLYSAYKDFNNGNECVS
What is the function of this protein?
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).  Regulates chemotaxis responses toward Na(1+) and Li(1+) salt ions and alkaline pH in ASE left (ASEL) sensory neuron.  Directly senses environmental alkalinity in ASEL neuron which probably leads to the activation of cGMP-gated cation channel tax2/tax4 (PubMed:23664973, PubMed:19523832).
What are the official names of this protein?
Receptor-type guanylate cyclase gcy-14.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, cilium. Note=Localizes in cilium of ASEL sensory neurons.
Protein: AAEA_SALSV
Sequence: MKTLTRKLSRTAITLVLVILAFIAIFRAWVYYTESPWTRDARFSADVVAIAPDVAGLITHVNVHDNQLVKKDQVLFTIDQPRYQKALAEAEADVAYYQVLAQEKRQEASRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADGWVTNLNVYAGEFITRGSTAVALVKKNSFYVQAYMEETKLEGVRPGYRAEITPLGSNRVLKGTVDSVAAGVTNASSTSDAKGMATIDSNLEWVRLAQRVPVRIRLDEQQGNLWPAGTTATVVITGKQDRDASQDSFFRKLAHRLREFG
What is the function of this protein?
Forms an efflux pump with AaeB.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeA, pHBA efflux pump protein A.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ASSY_RHOPT
Sequence: MTTILKSLPKGENVGIAFSGGLDTSAALLWMKQKGAKVFAYTANLGQPDEADYDAIPRKAMEFGAEKARLVDCRTQLVHEGIAAIQAGAFHVSTGGIAYFNTTPLGRAVTGTMLVSAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNPALRIYKPWLDQQFIDELGGRAEMSAFMTSHGFAYKMSAEKAYSTDSNLLGATHEAKDLEHLDSGIKIVNPIMGVPFWRDDCAVKAEAVTVRFEEGQPVALNGQTFTDPVAMFYEANAIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQYRINGMKLGRLLYQGRWFDSQALMLRETAQRWVARAVTGEVTLELRRGNDYSILNTVSPNLTYAPERLSMEKVEDAPFTPADRIGQLTMRNLDITDTRAKLGLYAKTGLLSSGEGTPIPQLENDKG
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.