PharMolix/UniProtQA huggingface dataset:
Protein: VE1_COPV6
Sequence: MAARKGTDSETEDGGWVLIEADCSEVDSADETSENASNVSDLVDNASIAETQGLSLQLFQQQELTECEEQLQQLKRKFVQSPQSRDLCSLSPQLASISLTPRTSKKVKKQLFATDSGIQSSNEADDSLEGQRQVEPLPGREENGADALFKVRDKRAFLYSKFKSSFGISFTDLTRVYNSDKTCSSDWVVCLYHVSDDRREAGKTLLQDHCEYFFLHSMGFCTLLLLCLFVPKCRNTLFKLCRSLFHISNVQMLADPPKTRSPAVALYWYKKGFASGTFTHGELPSWIAQQTLITHHLAAEKTFDLSEMVQWAYDNDLKDESEIAYKYAALAETDENALAFLKSNNQPKHVKDCATMCRYYKKAEMKRLSMSQWIDERCKATDDGPGDWKEVVKFLRHQGIEFILFLADFKRFLRGRPKKNCLVFWGPPNTGKSMFCMSLLSFLHGVVISYVNSKSHFWLQPLTEGKMGLLDDATRPCWLYIDTYLRNALDGNTFSVDCKHKAPLQLKCPPLLITTNVNVCGDEKFKYLRSRCSFFHFPQEFPLDDNGNPGFQLNDQSWASFFKRFWKHLDLSDPEDGEDGETQRGLRLTARGTTESV
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: YBJQ_SALDC
Sequence: MQFSTTPTLEGQSIVEYCGVVTGEAILGANIFRDFFAGIRDIVGGRSGAYEKELRKAREIALQELGEQAKALGADAVVGIDIDYETVGKDGSMLMVSVSGTAVKTRR
What are the official names of this protein?
UPF0145 protein YbjQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: Y3113_BACAA
Sequence: MKIYVDADACPVKDVIIFEATKAEIPVILVTSFSHYSNAEQPKGVETIYVDSGADAADYRIMQLAQKEDLIVTQDYGLASLALAKGCIVLHHKGYKYTNENIEQLLQTRYLSAMVRKSGKRTKGPKPFTAEDKEKFRALFKSMIAL
What are the official names of this protein?
UPF0178 protein BAA_3113.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: PURL_RHIL3
Sequence: MTIPNTIPITPELIASHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGVVDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNSFGVPTVGGEVEFDARYNGNILVNAFAAGIAKSNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTVQVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGILLELDKVPVREERMTAYEMMLSESQERMLMVLQPEKEEEAKAIFVKWGLDFAIVGWTTDDLRFRVMHQGEEVANLPIKDLGDQAPEYDRPWRESGKRAPLPANLVAAPEDYGQALLQLVGSANQSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVDGHPSKALAFSSDVTPRYVEADPFEGGKQAVAECWRNITATGAEPLAATDNLNFGNPEKPEIMGQFVEAVKGIGEACRALDFPIVSGNVSLYNETNGVAILPTPTIAGVGLLPDWSKMARIGSANDGDKVIMIGVDGSHLGQSVYLRDVLSSSEGPAPEVDLFAERRNGDFVRSVIRNGQATACHDISSGGLAVALAEMAMASGKGLTIDLSEGKGEPHALLFGEDQARYVLTLPADVADFVCVNAEGGGVPFRRLGTVGGTALVVGDLISLPIQQLRDAHESWFPDFMEGRGELAAAE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_GLOC7
Sequence: MIHQPPAGARDLLPLEVAQKGWINDCLQQVFQRWGYQRIVTSTIEWLDTLMAGGAIERSTVIQLQDTSEGTLGLRPELTASIARTAVSRMADSTYPQRICYRANVFRNPPPGYHGRQLEFYQAGVELLFAGGLLADGEILLLVADCLETLGLTDWHLILGEAGLTRSLLSVFPDPLRQQVRHCLAHLDYITLENLTYPSADLRERALLLFDLRGNPADVLSKVASLELEESDRIIVNNFKSLIHLIEQSHPNPLPLILDLSLVQTFDYYTGLVFKVVSSSDNQLRVLGQGGRYDQLLGLYHPQHQSAPGIGFSLNLEDLHLCLLSTSSSGMPRQIPVIDWLVIAQTTQSQVAAFNYAQLLRNSNTLVRVALDLGGRSPEEIRDYARTCRIKTLVWIGEDGTPRIETVQ
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END8_SALNS
Sequence: MPEGPEIRRAADNLEAAIKGKPLTDVWFAFAQLKPYESQLTGQLVTRIETRGKALLTHFSNGLTLYSHNQLYGVWRVIDTGEIPQTTRILRVRLQTADKTILLYSASDIEMLTAEQLTTHPFLQRVGPDVLDARLTPEEVKARLLSPRFRNRQFSGLLLDQAFLAGLGNYLRVEILWQVGLTGQHKAKDLNEAQLNALSHALLDIPRLSYTTRGQADENKHHGALFRFKVFHRDGEVCERCGGIIEKTTLSSRPFYWCPHCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: PEX22_ASHGO
Sequence: MVSKASRDQLRKYGAVSLASLLVAASIVAYRWWNAAPSIEVEKKLRRSVSRCVVVTQGIQNEDMIHDLLFEDTVMLLAPGCTAEGRLKSASRENAYKVISCTTWQSVWACVRHFRKHTLLVRTSEVPSGVPADIGGYVSDISDI
What is the function of this protein?
Involved in peroxisome biogenesis.
What are the official names of this protein?
Peroxisome assembly protein 22, Peroxin-22.
What is the protein family that this protein belongs to?
Belongs to the peroxin-22 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: P60_LISGR
Sequence: MNMKKATIVSAAGIAVTAFAAPSVVSANTVVVASGDTLWGIASKTGTTVDQLKQLNKLDSDRIVPGQKLTIKEVAAQKVEKSVSATWLNVRHAPDANEKILTSLKGRTVVKVESSEANGWNKISFDNGKTGYVNGKYLSDAKVAAPVVTKAVTHKAEAKVAATSTHAVKVDTNASTYKVKSGDTIWALSVKYGVPVQKLIEWNNLSSSSIYVGQTIAVKEAAAKAAPTTVKQAAPAKVAPKQEVKQTAPAKQEQAKPAAKETVKPAVSKPKAATPAPTAKPAVEQKASTPAVDTNAATYKVQNGDSLGKIASLFKVSVADLTNWNNLNATITIYAGQELSVKASAAKPKPAAPAKPAVSKPATSTPAKVTPTNTTNNSTPTTNVNNNTSQSSSASFSALYAEAKKHLGKPYTWGARGPSTFDCSGFTSYVFNQVGLSLSGNSATQYANSTKISESQAQPGDLVFFNYGSGIAHVGIYIGGGQMIDAQDNGVSIDNIHGNGWGQYLVGFGRV
What is the function of this protein?
This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria.
What are the official names of this protein?
Probable endopeptidase p60, Invasion-associated protein p60.
What is the protein family that this protein belongs to?
Belongs to the peptidase C40 family.
Protein: CWP08_TOBAC
Sequence: AQPPQQADFL
What are the official names of this protein?
52 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: YFEO_SALDC
Sequence: MFHPRARTMLLLSLPALIIGVASSLVLIAAMKVASVFQQFLWQRLPTSIGIAYDSPFWIVGMLTLTGIVVGLIIRYSPGHAGPDPAIEPLISMPVSPSALPGLLLALIIGLAGGVSLGPEHPIMTINIALAAAFGSRLFPRITALDWTILASAGTIGALFGTPVAAALIFSQTLSGSNDIPMWDRLFAPLMAAAAGSLTTSLFFHPHFSLPIAHYTQMRLVDIASGAIVAAIAIAAGMVAVWCLPRLHELLHRLKNPVLILGIGGFILGILGVIGGPLTLFKGLDEMQQMAFSQTLGAGDYFTLAVVKLAALVIAAASGFRGGRIFPAVFIGAALGLMLHAHVEAVPAAITVSCAILGLVLVVTRDGWLSLFMAAVVVPDTNLLPLLCIVMLPAWLLLAGKPLLAANRHEP
What are the official names of this protein?
Putative ion-transport protein YfeO.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CA11_CONMR
Sequence: MGMRMMFTVFLLVVLATTVVSFTSDRASDGRKAAAKDKASDLVALTVKGCCSHPACSVNNPDICG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  This toxin inhibits rat alpha-7 and weakly alpha-6/alpha-3-beta-2 and alpha-3-beta-2 nAChR.  In vivo, this toxin shows analgesic effect.
What are the official names of this protein?
Alpha-conotoxin Mr1.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YG2C_YEAST
Sequence: MVLLHPILAESCTRYFLLLPSYTHPNHLFHFPSISFFFFFFFFFFSFRRNCLFRIVKDEVKYSGVYYYIHTKQDKETFLDLTFYFNCFCIPYNKKDLLFNVGVIRPLLDLQ
What are the official names of this protein?
Putative uncharacterized protein YGR069W.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LUXS_HAEI8
Sequence: MPLLDSFKVDHTKMNAPAVRIAKTMCTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLFAGFMRDHLNGDSIEIIDISPMGCRTGFYMSLIGTPNEQEVSEAWLASMQDVLGVQDQASIPELNIYQCGSYTEHSLEDAHEIAKNVIARGIGVNKNEDLSLDNSLLK
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: HIS8_CHRSD
Sequence: MSKFWSPAVRELTPYVPGEQPRERLIKLNTNENPYPPAPGVEQVLREFPVDHLRLYPDPSATALREALAETYDVATEQVFVGNGSDEVLALAFQAFFRQSRPLLMPAISYSFYPVYCKLYDVAYRSVALDDQWRVPLTAFDTDNGGIVFANPNAPTGHGHSRDAIAALLERNTESVVLVDEAYVDFGGESAVPLVERFPNLLVTGTFSKSRSLAGLRLGYAIGSRELIEGLERVKDSFNSFPIDRITIDAGIAALHDRAYFEACRERVITTRERTRQRLESLGFEVMPSQSNFLFVRHETYEGRAIFGELRERGILVRHFDKEALSDFLRISIGTEDEMDSLIEALEAVCR
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: Y779_LISMO
Sequence: MVWDATNIFLFAANILTVLYILYNDAVIPLWKGKTVLSVKLRSRGRWDGYIFVGIIVLLFVSNTFFREGPFSTSVLLGIMGVLFIYICFFRSSKAVFKESGLFYALLFFPYAKIERMNLSEDGVLVIETNRQRLMLFARSEKDLEKMLAVFTTYS
What are the official names of this protein?
UPF0266 membrane protein lmo0779.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NU4C_CYCTA
Sequence: MSDLPWLTIIVILPISAGSSIPLFPHRGNNIIRWYTLGICLLEFLLMTYTFRYHFHFDDPLIQLEEDYDWIDLIDLHWRLGIDGLSIGPISLTSFVTTLATLAAWPVTRNPRLFYFLMLAMYSGQVGLFASRDILLFFLMWELELIPVYLLISMWGGKRRLYSATKFILYTAGGSIFISMGASSMGLYGFDGPTLDFEILANKYYPVVLEIVFYLGFFIAHAIKLPILPLHTWLPDTHGEAHYSTCMLLAGIPLKMGGYGLIRINMELLPHAHSLFSPWLVIVGAVQIIYAALTSLSQRNLKRRIAYSSVSHMGFVIVGIGSMADTSLNGAILQMISHGLIGAALFFLAGTSYDGIRTLFLDGIGGMAIPMSKISTMFSSFSMASLALPGMSGFVAESMVLLGIITSRKYSLTFQIVIAAIMAIGMILTPIHLLSMLRRMFYGYKFLNVLNPYLKDSGPREIFISICLFLPVIGTGTYPDLVLSLWDKKVEAIMFRSFHE
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: IF1A_METBU
Sequence: MKKNNGGRGSKTDAPAVTRVRTPRRENNEILATVSALLGGKRVTLQCMDGIVRMGRIPGSKKKRMWVREGDIVIITPWDFQDSKAEVIWKYTRPQVEWLERKGFLK
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
What are the official names of this protein?
Translation initiation factor 1A, aIF-1A.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: TM248_DANRE
Sequence: MVLLLNPLENLKTYISNRPPLVIFMVSVSAVAIAFLTIGYFFKIKEIKSPEMTEDWNTFLLRFNEIDFCISENETLKHGLNESITPESTVTSSQTRSSTQSPPLLEDPGPINISVAITLTLDPLRPFGGYSRNITHLYASVLGQQVGLAGREAHEEMNITFTLPVAWNSDECVLHGRCEQMVFSTCMTVTAASNVFPVTMQPPHCVPETYSNATSWYKIFTTARDSDTKYTQEYNPFWCYKGAIGKVYHTLNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPGKVRQNNPDFCQEKVALSAG
What are the official names of this protein?
Transmembrane protein 248.
What is the protein family that this protein belongs to?
Belongs to the TMEM248 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DXS_MYCUA
Sequence: MLQQIRGPADLQHLSQAQLRELAQEIREFLVHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQTYVHKMLTGRAQDFESLRKKGGLSGYPCRAESEHDWVESSHASAALSYADGLSKAFELSGLRNRHVVAVVGDGALTGGMCWEALNNIAASHRPVVIVVNDNGRSYAPTIGGVADHLAKLRLQPAYEQVLEKGRDVVRAVPLVGEVCYHFMHSVKAGIKDSLSPQLLFTDLGLKYVGPVDGHDERAVEVALRSARGFGGPVIVHVVTRKGMGYGPAEADVAEQMHSTVPIDPATGQATKLAGPGWTTTFADALIEYAGKRRDIVAITAAMPGPTGLTAFGQQFPDRLFDVGIAEQHAMTSAAGLAMGGMHPVVAIYSTFLNRAFDQIMMDVALHQLPVTMVLDRAGITGSDGPSHNGMWDLSMLGIIPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDIPALERRDGMDVLAVPASGLNHDVLLIAVGALASMALAVAKRLHNQGIGVTVIDPRWVLPVADGIGDLAVAHKLVVTLEDNGVNGGVGSAVSAALRRAEIGVHCRDVGLPQQFFEHASRGELLADLRLTDQDVARRVTGWVAALGACVSEAEIKEHLD
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: S2538_EMENI
Sequence: MSNNASPQAAYVPAVKPVSKSSKTTFHFGAGLLSGLTSSILLQPADLLKTRVQQSAHPSSVFSTVKAILSSPNPVRNLWRGTLPSALRTGFGSALYFTSLNALRTSLASTSLTNYDADVKKIGNGSSALPKLSHSANLATGAAARVAAGFVMMPVTVLKVRYESDYYAYRSLYSAGRDIVRTEGVRGLFSGFGATAARDAPYAGLYVLFYEQLKRYLSATTSSTELPSSSSINFVSGGLAAGLATAITNPFDAVKTRLQLMPGKYGNMIRAVRLMVREDGVRSLFGGLGLRIGRKALSSALAWTVYEELILRAEMKWARDEAEARL
What is the function of this protein?
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix.  Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
What are the official names of this protein?
Mitochondrial glycine transporter, Solute carrier family 25 member 38 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GTHB2_TRITC
Sequence: MTVEISKVFVLMMLNLFLGASSSIWSVAPAAFQLPPCQLINQTVSLEKEGCPRCHAVETTICSGHCLTKDPIIKIPFSNVYQHVCTYRDLFYKTFEFPDCPPGVDPVVTYPVALSCHCSRCVMDTSDCTFESLQPDFCMNDIPFYY
What is the function of this protein?
Involved in gametogenesis and steroidogenesis.
What are the official names of this protein?
Gonadotropin subunit beta-2, GTH-II-beta, Gonadotropin beta-II chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: CP21B_ARATH
Sequence: MAITATRLVSLTLLWIVVLFVTLALIQIKLTDVADPSVNEKILDAKLNQVGEDLEGVTHKVYFDIQINGSPAGRILIGLFGNIVPKTAENFRSLCTGEKGVGNMGKPLYFKGSSFHRIIPGFMIQGGDFTRGDGRGGESIYGDKFADENFKLKHTGPGFLSMANSGPDSNGSQFFITTVTTSWLDGHHVVFGKVLSGMEVVRKIEAQGQDSGVPKANVIIFASGEVSL
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase CYP21-2, PPIase CYP21-2, Cyclophilin of 21 kDa 2, Cyclophilin-21-2.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: HIS6_DEIGD
Sequence: MLTKRIIPCLDVQNGRVVKNVRFFENHRDAGDPLALAQLYEAQQADELVFYDITATHEGRQLLLDVAARVAEQVMMPLTVGGGVNAVSDFRQLLLAGADKISVNSGAVRRPELIREASDHFGAQCVVLSIDAKRRPGSEGWTVHVGGGRVDTGLDLIEWAQQGQALGAGEICLNVMDADGTRAGFDLEATRAVASAVDLPVIASGGAGRLEDFRDVLLDGETGGRADAALAASVFHFGELTVPQVKTYLRGEGLPVRPEWREA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNJ5B_BOVIN
Sequence: MACNIPNQRQRTMSTSGKALYEILGLHKGASNEEIKKTYRKLALKHHPDKNPDDPGAAEKFKEINNAHTILTDMSKRNIYDKYGSLGLYVAEQFGDENVNTYFMLSSWWAKTLFVIIGLLTGCYFCCCLCCCCNCCCGRCWTKSSMPEEDFYVSPEDLEEQIKTDIAKDMDFPVVLQPTNANEKTQLIREEPRSYCTDS
What are the official names of this protein?
DnaJ homolog subfamily C member 5B, Cysteine string protein beta, CSP-beta.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor.
Protein: SOCS7_HUMAN
Sequence: MVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCPCPPQPPPPQPQPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGEQQQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQEVEPST
What is the function of this protein?
Regulates signaling cascades probably through protein ubiquitination and/or sequestration.  Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation.  Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.  May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Suppressor of cytokine signaling 7, SOCS-7, Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4, NAP-4.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
Protein: YJ41A_YEAST
Sequence: MATPVRGETRNVIDDNISARIQSKVKTNDTVRQTPSSLRKVSIKDEQVRQYQRNLNRFKTILNGLKAEEEKLSEADDIQMLAEKLLKLGETIDKVENRIVDLVEKIQLLETNENNNILHEHIDATGTYYLFDTLTSTNKRFYPKDCVFDYRTNNVENIPILLNNFKKFIKKYQFDDVFENDIIEIDPRENEILCKIIKEGLGESLDIMNTNTTDIFRIIDGLKKQNIEVCMVEMSELEPGEKVLVDTTCRNSALLMNKLQKLVLMEKWIFSKCCQDCPNLKDYLQEAIMGTLHESLRNSVKQRLYNIPHDVGIDHEEFLINTVIETVIDLSPIADDQIENSCMYCKSVFHCSINCKKKPNRELRPDSTNFSKTYYLQGAQRQQPLKSSAKRTKVLEQDTKKVEQSVQQQKTGNY
What is the function of this protein?
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.
What are the official names of this protein?
Transposon Ty4-J Gag polyprotein, TY4A, Transposon Ty4 protein A.
Protein: NRX1B_BOVIN
Sequence: MYQRMLRCGAELGSPGGGGGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGNSPTKEPVSQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYV
What is the function of this protein?
Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins.  Plays a role in formation of synaptic junctions.
What are the official names of this protein?
Neurexin-1-beta, Neurexin I-beta.
What is the protein family that this protein belongs to?
Belongs to the neurexin family.
What are the subcellular locations of this protein?
Presynaptic cell membrane; Single-pass type I membrane protein.
Protein: RPOA_NEOSM
Sequence: MSAVLDKGSLVDVFSSPSVVFNQIREGYCAEFIVEPLRVGFGLTIGNAMRRVLLSSLSGFAISAVGIKGLTHEFSCIPGVREDFADLALNLKKVVLKSISGATCGNLHLSVTDGGAVFSNMISPSHDFEVVNGDLLICNVAEGVSLEMEMKVSSGFGYVSSVSVRKDEYDLEGAVPIDAIYNPVRAVNFTVKPTSAGSFAGHDKLILYVETNGAMDPKTAVLEASKILSTQARCFLNIADPEHRVHGVPCGVSTSDRNDASDLLSARIDRLYLSARARKCLNGENIVYIRDLVSRTEADLLKAPNFGRRSLEEVKKELFSKGLSLGMNLDSHG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: COAD_GRAFK
Sequence: MKKAVFPGSFDPLTLGHTDIIDRALPLFDEIILAIGTNSSKKYMFSLEDRLHFLKETYKNESKVKVETYKGLTVDFCKSQNAGFILRGLRNGQDLEFEKSIGQTNYKMSGIDSIFLLSSSGKAHISSTVVRDVMHHGGNYEFMVPDVVRKK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PR3B1_MESAU
Sequence: MQLPLTPLSFSGTLLLMAMSNFLLWEHVTSSASPRLSTRNLYQRVVELSHCTHDLASKVFTDFNMKFGKSICRQKLMLYTCHTSSIPTPENREQVHQTNSEDLLKVTISVLQAWEEPVKHMVAAVAALPGTSDAMLSRAKELEERVLGLLEGLKIILNRIHPGAVENDYTFWSGWSDLQSSDEATRNIAFYTMGRCLRRDTHKVDNYLKVLKCRDIHNNNC
What are the official names of this protein?
Prolactin-3B1, Chorionic somatomammotropin hormone 2, Placental lactogen II, PL-II.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL34_STRPJ
Sequence: MKRTYQPSKLRRARKHGFRNRMSTKNGRRVLAARRRKGRKVLAA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.