PharMolix/UniProtQA huggingface dataset:
Protein: TYW23_ARATH
Sequence: MDFEKRKAATLASIRSSVTDKSPKGFLDEPIIPLLETINHHPSYFTTSSCSGRISILSQPKPKSNDSTKKKARGGSWLYITHDPADSDLVISLLFPSKSNQIDPIDQPSELVFRFEPLIIAVECKDLGSAQFLVALAISAGFRESGITSCGDGKRVIIAIRCSIRMEVPIGDTEKLMVSPEYVKFLVDIANEKMDANRKRTDGFSVALASNGFKNPDENDVDEDDNYENLAANHDSSINNGNLYPGVQKELIPLEKLSIVGEPVEKLHLWGHSACTIDESDRKEVIVFGGFGGFGRHARRNESLLLNPSCGTLKLIAVNESPSARLGHTASMVGDFMFVIGGRADPLNILNDVWRLDISTGEWSSQRCVGSEFPPRHRHAAASVGTKVYIFGGLYNDKIVSSMHILDTKDLQWKEVEQQGQWPCARHSHAMVAYGSQSFMFGGYNGENVLNDLYSFDVQSCSWKLEVISGKWPHARFSHSMFVYKHTIGIIGGCPVSQNCQELTLLDLKHRLWRSVRLEFMNKELFVRSTASILGDDLIVIGGGAACYAFGTKFSEPVKINLVQSVTMSENHLPPQPEDVSLESNKNNADLKTETSLSQPWVIQLERKYAKFGKDILKSFGWLDLERKVYSNEKGLCICFPVTENFSELFHEKQLLGKDFERSEENNLTKGLSLKDISCSAALNLLKEHGAKKLINVAFEAKKVAKSPLQRMREDITSILKQKGLPEELLDELPQKWERLGDIVVVPATSFKDPTWSSINDEVWCAVSKSLSANRLARQGRVEPNGTRDSTLEILVGDNGWVNHRENGILYSFDATKCMFSWGNLSEKLRMGNMACENEVVVDLFAGIGYFVLPFLVRAKAKLVYACEWNPHAIEALRRNVEANSVSERCIILEGDNRITAPKGVADRVNLGLIPSSEGSWVTAIQALRPEGGILHVHGNVKDSDESSWGEHVTKTLSDIARAEGRSWEVTVEHIEKVKWYAPRIRHLVADVRCR
What is the function of this protein?
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 2/3/4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the TYW3 family.
Protein: KAP22_CRIFA
Sequence: MLRRTVSNFAMSPYMLFISDLAKTGKLKGIRTPGKFVGKKYRQLSAKEKAALQQRAKQASTPAMTAYRRMAHREMSNKSVPIEQRRANLTKKWNETKQAQRAKAQKAQKKPKSAKSKVKKAAKKAKKSKK
What is the function of this protein?
Histone H1-like DNA-binding protein involved in the organization and segregation of kinetoplast DNA (kDNA).  The mitochondrial DNA of kinetoplastid protozoa consists of about 5,000 minicircles and 20 to 30 maxicircles.  These circular DNAs are held together by catenation into a highly organized compact disk structure referred to as a kinetoplast DNA (kDNA) network.  Binds preferentially to a specific fragment of minicircle DNA and is able to compact kDNA networks through DNA charge neutralization and condensation.
What are the official names of this protein?
kinetoplast-associated protein 2-2, Histone H1-like protein p18-2.
What is the protein family that this protein belongs to?
Belongs to the KAP family.
What are the subcellular locations of this protein?
Mitochondrion matrix, kinetoplast.
Protein: MQMTN_HELPY
Sequence: MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAIFIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL
What is the function of this protein?
Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species.  Can also probably catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2.  Does not act on futalosine (FL) as substrate.
What are the official names of this protein?
Aminodeoxyfutalosine nucleosidase, AFL nucleosidase, Aminofutalosine nucleosidase, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 6-amino-6-deoxyfutalosine N-ribosylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: GPPA_SHIDS
Sequence: MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPIADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQYMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQESQWQSYVHWPLEVH
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: Y1796_STRP3
Sequence: MTHNHENDHQHEVITLVDEQGNETLFEILLTIDGREEFGKNYVLLVPAGSEEDESGEIEIQAYSFTENEDGTEGDLQPIPEDSDAEWDMIEEVFNSFLDEN
What are the official names of this protein?
UPF0473 protein SpyM3_1796.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: ACAP_LACLM
Sequence: MDTKKIRWFTVAFIAFNMVWGMGNVVNNFAQQGITVVTSWLLILALYFIPYALIVGQLCSTFKDSKGGVSSWVENTSTKRLAYYAAWTYWVVHIPYLAQKPQAILIAFGWVGQGNGNLVSQMSMTAVALISLAIFLAFLWLSTKGLNTLKVIGGLAGTAMFVMSLLFIVMAIGAPFIAKDFHIATPDMGNIKTYIPKFDFSYFTTISMLVFAVGGAEKISPYVNQTKNPAKEFPRGMFLLAGMVGICAVLGSIAMGMIFSSGNLPKDLMANGAYAAFQILGQHFGVGNFLMIVYALTNGVGQIAALAFSIDAPLRILLADADPEYVPAWLRKKTNKGTLKNGYTLTGILVSIIILLPLLGIGDMNELVKWLTNLNSVVMPMRYLWVFFAFIMLNRAVKHFQSEYKFIKQKRLAMIAGAWCFLFTLIACVLGMVPKLDYAANPSAWWFQLASNILTPIVLILLGMLLPFIARREQRKATSLDLDTIVTPD
What is the function of this protein?
Involved in aspartate and glutamate uptake.  Plays no significant role in the excretion of accumulated glutamate.
What are the official names of this protein?
Aspartate/glutamate permease AcaP.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Glutamate:GABA antiporter (GGA) (TC 2.A.3.7) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM1_PELPD
Sequence: MNIIVVGLSHKTAPVEVRERVAFSPNLIERPLRELVSLDDISEGVIVSTCNRVEIYATTHDIAGGTARIKRFLADHHRIPLESLEQYLYSYHSEAAIRHVFRVASSLDSMVVGEPQILGQIKTAYGYAAEYRTSGTILNRFLHKAFSVAKRVRTETRIASSAVSVAFAAVELARKILGDLSGKTVMLIGAGEMCELAAKHFLTSGARGLLVANRTFAKGERLAAEFGGEAIPFEELFQELHRADIVLSSTGAPHTIIAPRDVEAVVKRRKFKPMFFIDIAVPRDIDPRVNDLESAYLFTVDDLQEIVEANMAQRNQEASKGEEIVEQEIGQFHCWLSSLESTPTIVALRARFEEIRRAELEKTLCGWKDLSPEAEKRLEIMTLSIMNKLLHTPTAVLKRAGQGGRTDLYTDALRQLFDLQTSRQDDDELELELEEE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PYRB_SHISS
Sequence: MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLDPSEYANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDLVL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: ACSF1_SYNY3
Sequence: MVNTLEKPGFDEIRPGVKTPAKETILTPRFYTTDFDEMAKMDISPNEDELRAILEEFRVDYNRHHFVRNESFNKSWDHIDGEKRQLFVEFLERSCTAEFSGFLLYKELGRRLKNKNPLLAECFNLMSRDEARHAGFLNKAMSDFNLSLDLGFLTKSRKYTFFKPKFIFYATYLSEKIGYWRYITIYRHLEKNPNDCIYPIFEFFENWCQDENRHGDFFDAIMRAQPHTLNDWKAKLWCRFFLLSVFATMYLNDTQRADFYACLGLEARSYDKEVIEKTNETAGRVFPIILDVNNPEFYNRLETCVSNNEQLRAIDASGAPGVIKALRKLPIFASNGWQFIKLYLMKPIAVDQLAGAVR
What is the function of this protein?
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis.  Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).
What are the official names of this protein?
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1, Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1.
What is the protein family that this protein belongs to?
Belongs to the AcsF family.
Protein: FADJ_ECO55
Sequence: MEMTSAFTLNVRLDNIAVITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDNFIAGADINMIGNCKTAQEAEALARQGQQLMAEIHALPIPVIAAIHGACLGGGLELALACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALKLGLVDDVVPHSILLEVAVELAKKDRPSSRPLPVRERILAGPLGRALLFKMVGKKTEHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRSIFFASTDVKKDPGSDAPPAPLNSVGILGGGLMGGGIAYVTACKVGLPVRIKDINPQGINHALKYSWDQLEGKVRRRHLKASERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQNSAAHTIFASNTSSLPIGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATTVKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERVEHIDAVLVKFGFPVGPIQLLDEVGIDTGTKIIPVLEAAYGERFSAPANVVSSILNDDRKGRKNGRGFYLYGQKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCVDEQVIRSVRDGDIGAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVEMGARGESFWKTTATDLQ
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOCS3_HUMAN
Sequence: MASREEVLALQAEVAQREEELNSLKQKLASALLAEQEPQPERLVPVSPLPPKAALSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTNCADGGVLGVVTGVLGCLQALEVLKIAAGLGPSYSGSLLLFDALRGHFRSIRLRSRRLDCAACGERPTVTDLLDYEAFCGSSATDKCRSLQLLSPEERVSVTDYKRLLDSGAFHLLLDVRPQVEVDICRLPHALHIPLKHLERRDAESLKLLKEAIWEEKQGTQEGAAVPIYVICKLGNDSQKAVKILQSLSAAQELDPLTVRDVVGGLMAWAAKIDGTFPQY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Also essential during biosynthesis of the molybdenum cofactor.  Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A.  Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase MOCS3, Molybdenum cofactor synthesis protein 3, Molybdopterin synthase sulfurylase, MPT synthase sulfurylase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_DICNV
Sequence: MAHGVDRTRRIGEQMRRDLAQALVDIVHHPHASLLSFTAVHLTRDLSFAKVYVTHVLDNEEERSELVAELNAKAGQFRHYLAKNLSIRKVPELQFYYDQSVEYGARMEQLLTHLVKDSEHKD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4A9_TOBAC
Sequence: MAGAAPEGSQFDARQYDSKMTELLNAEGQDFFTSYDEVYHSFDAMGLKENLLRGIYAYGFEKPSAIQQRGIVPFCKGLDVIQQAQSGTGKTATFCSGILQQLDYELLDCQALVLAPTRELAQQIEKVMRALGDYLGVKVHACVGGTSVREDQRILSSGVHVVVGTPGRVFDMLRRQSLRPDHIKMFVLDEADEMLSRGFKDQIYDIFQLLPPKIQVGVFSATMPPEALEITRKFMNKPVRILVKRDELTLEGIKQFYVNVDKEEWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTQPENYLHRIGRSGRFGRKGVSINFVTSDDERMLSDIQRFYNVVIEELPANVADLL
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
Eukaryotic initiation factor 4A-9, eIF-4A-9, ATP-dependent RNA helicase eIF4A-9.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein: DABA_BACLD
Sequence: MKAAPTLSKQLIFQYEHQTADFNMDELVQSAARVIAPLWPIETFAARHPWMGLEEQTFEQTARQLKQQLHVDIYPKSSIFRSAKQRGEIDETILEKKLINWLDSHQPGMQRETAEAFCKAALKLDEIPGQLLRSRQVKKLAKQAARGTIDGRKTSFIKPLSVFAGQKSAHLLDHHVIKWCKLFLDESQSAWRLPHREKGFYSAWRQLVEHDPALSRAERQRLNGWPEEPRDAMKKALRAFDISNADVQAYLEAHLLSLPGWAGMMLWRSQQSQDEEELLLEYLAVRLSMEWMLVEPYLPLPKPNPEKEMQLVPLIASWLHWGGLTPEEWLELSAAEQKARLTLARRFDDITRRRLWLEAWEQTYAAEVRKLITANKPAAADKSETVLAQFAFCIDVRSEPFRRALEKSGPFETYGTAGFFNMAIETCELGTKHSHSSLPVILKPQHRVEETAEELPFKSYQEHKKAAASLSSAFKTMKQNLLAGMLLPEVSGPWLSLQMAARSLVPRAAGQAFRNARKTWLKKPQTKLSLDRTETSEAGIPVGFTEEEKAAYARQALKMMGITDRFAPLVVICGHGSRSTNNPYASALDCGACGGASGAFNARVLAALCNLPSVRERLRSDGIFIPDDTVFAAAEHITTLDELHWLYVPELPAKAQQAFDRINSVLPDVSRTVGAERLEELPQLGYQNPRNEVERFAEDWSEIRPEWGLARNASFIIGTRRLTRGADLEGRAFLHSYDWRNDEDGSILSGIISGPGTVAQWINLQYYASTVAPHYYGSGNKATQTVTAGLGVMQGNASDLLAGLPWQSVMRSDDEIYHAPLRLLIVIEAPDDDIERLLDRDHSFRQKAENGWIHLASINPEGKWKNWTNTINE
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ASSY_RHOBA
Sequence: MKSCVLAYSGGLDTSVILGWLQDQGYEVHCVYVDLGQPCEDRDAIMEKARTCGAKSSRLVDVREELCRDFAFPVLAWQAKYEQIYLLGTSIARPLISKVCLEVAREVGATAYAHGATGKGNDQCRFQLAAEALDPNIEMIAPWRIKSFRDAFPGRTELIEYCDVKRIPVKASTAKPYSSDENVLHISYEAGKLEELDVNGVELVEFGMGVSPQDAPDKPEEVTIGFESGVPKTLNGKAVNALEMVEQLNDIAGRNGVGRIDMVENRFVGMKSRGVYESPGMTVLYDALMYVEQLTMDRDLMHLRDRMAPEVAEMVYYGFWYTPKMDALMSFIETAQRPVTGEVTLQLYKGNIMVSSRTSPNSLYDEEIATMEGGGSYNQDDAEGFLRIQGLPSRVQGRVSPRKF
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_XANC8
Sequence: MTMEAKAILRTARISPQKARLVADQVRGLSAERAVNLLKFSDKKAAHLIKKVVESAIANAENNQGADVDELKVKTIMVDEGPSLKRFMARAKGRGTRILKRTSHITVVVGAAK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: H2B2_SOLLC
Sequence: MAPKAEKKPAEKKPAEEKKAEKTPKAGKKLPKESGSSGADKKKKKSKKSIETYKIYIFKVLKQVHPDIGISSKSMGIMNSFINDIFEKLAQESSRLARINKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.2, LeH2B-2.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: UFC1_BOVIN
Sequence: MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCSQ
What is the function of this protein?
E1-like enzyme which specifically catalyzes the second step in ufmylation.  Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage.  Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
What are the official names of this protein?
Ubiquitin-fold modifier-conjugating enzyme 1, Ufm1-conjugating enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
Protein: RSMA_OPITP
Sequence: MPLTPTATRELLAQLGHQPKRFLGQNFLVDGNIVRKSLELAQVRRGDAVVEIGPGLGTLTGALLEAGAEVWAVEKDRTLHAHLSSTLQPRHPDTFHLLEADAVEHPLADLPAAHAAAFKIVANLPYAIATPWLDAVLGGPLPERMVLMLQQEAAQRYVAMPGSKSFGAISVFLQSAYEVAPGHRVEASCFFPRPDVDSYLLHLVRRAEPFVFTPEVKALIRSVFQQRRKQIGGLLRDRLPDHGASWLARLTAAGLSSLTRPEAIPTELWRALQVRES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMO_SYNFM
Sequence: MVSKSAALVSLGCAKNLVDSESMVSQLIELGYEMTPEVSQAALILVNTCGFLESAVRESIDTVLQLAGYKASGSCEKLVVAGCMVQRYGKKLLGLLPEVDLFLGTSHCHALKSFIRDHEAGSSERLRIAFPDHVDNGADRHLVEGRSSAYVKIAEGCGNRCAFCLIPRLRGPYRSRRAVDILREAHRLVACGAKELNIVAQDTTAFGSDRGEEHALVSLLESLEEIEKLEWVRLLYAYPDRITPELIRTMSQSRKVVPYLDIPLQHCVPRILASMGRSGTDPERIVDAIRSGIPGVALRTSLIVGFPGETEADFQALTAFVECTGFEHLGVFAFSPEPGTRAARMPDRVPPDVAQERRKVLLELQRGISRRRLESLVGRVLPVLVEGFHPETDLLLTGRLAVQAPEADGTVLITDGIGTPGEIMRCRVTAAHDYDVEAELLSAS
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTRF1_ARATH
Sequence: MRVLIRPNFLSNLIRYCSRGTHSHDRSLRSVLSSNMIRLYTTGMEPQLSPDLIKIMDQRLSAIEHRNAVLQKLINQPEYSPEEFSRANKELRKLRDSMLLINDLRAKQKEIDGLKSLVSESSDDKDMLDLAVGELDEAVEEEKRLQTLLLKSLLPKDEADERDCILEVRAGTGGEEASLFAMDIFRMYERYSQKKGWKFDIVDITESDMKGYKEASAAICGASVYGKLKFESGIHRVQRIPITEKSGRIHTSAISVAILPQADEVDVQLRNEDLRIDTYRSGGSGGQHANTTNSAVRIIHLPTGMMVSIQDERSQHMNRAKALKVLCARLYEIERLRIQSSRSKLRSDQIGSGDRSGRIRTYNFPQGRVTDHRVGITHHAIEDMMQGENLDMFIDALLLRQEMDAIASFSSTS
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA in mitochondria.
What are the official names of this protein?
Peptide chain release factor 1, mitochondrial, AtmtRF1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PYRH_ACICJ
Sequence: MTAQDQTDHTRYRRVLLKVSGEALMGRRDYGLDTDTVAAIAQDIADVVAMRVEVCLVIGGGNIFRGISGAAGGMDRAQADYMGMLATVMNALAMQSALEKRGVATRVQSAIPMSAVCEPYIRRRAERHMEKGRVVIFAAGTGNPFFTTDTAAALRAVEMKCDVLLKGTQVDGVYSADPRKVADAERYAELTYHEVLARDLSVMDAAAISIARENDLPIIVFNIHAPGAFASVMRGEGKFTRIVEQR
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K1210_HUMAN
Sequence: MRAGWTPRGFSAFHASLLPGRHPYLAHLGPRDRGARIGSRAYSQGCCSCLWLTYKGKKEGSTKGELGPAAVTDLEIPSYSRGFLPCTPRFPTTWCRGPGCFCGTAVIAGNLGDLARIVGPSHHASQLLLLQEQDSGNHPTMAESLSEISDSLDVLEAGDEGKKKCKFKALKSFFVKKKEKEAEDTQEEEMLELSLSSSNINISSLQPVRENQPTKARAKSSMGSKALSHDSIFMLGPEPERSASKMFPSMDPQRGRPQQRSHISRTLPKPRSKVPGVVSGAMSGAVLQNVPTSAVWVAGPKITENPPSRRRRLSIIPPVIQPEIISKNLVEISLDDESPKNPQKKALPHKSLTATQSFSELSSGPDCSQSLTAFATLASTSSTQLPIGFSTPATTQGCLDSSAARHKMTLNPRKQKKNLQVIIRGLPVWFSHFQGILEGSLQCVTQTLETPNLDEPLPVEPKEEEPNLPLVSEEEKSITKPKEINEKKLGMDSADSSSQKQNNKTEMYDKKTTDQAPNTDASRSQGYPMSAAYGRRWRRKGASVSGLSGCEFKGRSLKQSSEGYGLGDRAGSSPTNKTARNVPFSHLSLEKDNMEQPTTSQPETTTPQGLLSDKDDMGRRNAGIDFGSRKASAAQPIPENMDNSMVSDPQPYHEDAASGAEKTEARASLSLMVESLSTTQEEAILSVAAEAQVFMNPSHIQLEDQEAFSFDLQKAQSKMESAQDVQTICKEKPSGNVHQTFTASVLGMTSTTAKGDVYAKTLPPRSLFQSSRKPDAEEVSSDSENIPEEGDGSEELAHGHSSQSLGKFEDEQEVFSESKSFVEDLSSSEEELDLRCLSQALEEPEDAEVFTESSSYVEKYNTSDDCSSSEEDLPLRHPAQALGKPKNQQEVSSASNNTPEEQNDFMQQLPSRCPSQPIMNPTVQQQVPTSSVGTSIKQSDSVEPIPPRHPFQPWVNPKVEQEVSSSPKSMAVEESISMKPLPPKLLCQPLMNPKVQQNMFSGSEDIAVERVISVEPLLPRYSPQSLTDPQIRQISESTAVEEGTYVEPLPPRCLSQPSERPKFLDSMSTSAEWSSPVAPTPSKYTSPPWVTPKFEELYQLSAHPESTTVEEDISKEQLLPRHLSQLTVGNKVQQLSSNFERAAIEADISGSPLPPQYATQFLKRSKVQEMTSRLEKMAVEGTSNKSPIPRRPTQSFVKFMAQQIFSESSALKRGSDVAPLPPNLPSKSLSKPEVKHQVFSDSGSANPKGGISSKMLPMKHPLQSLGRPEDPQKVFSYSERAPGKCSSFKEQLSPRQLSQALRKPEYEQKVSPVSASSPKEWRNSKKQLPPKHSSQASDRSKFQPQMSSKGPVNVPVKQSSGEKHLPSSSPFQQQVHSSSVNAAARRSVFESNSDNWFLGRDEAFAIKTKKFSQGSKNPIKSIPAPATKPGKFTIAPVRQTSTSGGIYSKKEDLESGDGNNNQHANLSNQDDVEKLFGVRLKRAPPSQKYKSEKQDNFTQLASVPSGPISSSVGRGHKIRSTSQGLLDAAGNLTKISYVADKQQSRPKSESMAKKQPACKTPGKPAGQQSDYAVSEPVWITMAKQKQKSFKAHISVKELKTKSNAGADAETKEPKYEGAGSANENQPKKMFTSSVHKQEKTAQMKPPKPTKSVGFEAQKILQVPAMEKETKRSSTLPAKFQNPVEPIEPVWFSLARKKAKAWSHMAEITQ
What are the official names of this protein?
Acrosomal protein KIAA1210.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localizes to the sex body in spermatocyte, acrosome, and near the ectoplasmic specialization.
Protein: DDL_LEUCK
Sequence: MTKKYVALIFGGNSSEHDVSKRSAQNFYDAILATGKYRITVFAIAQNGYVLDPERSKRILALEDERPIVADYMTTVDQQDPLSRINALRAAGDFDIFFPVVHGNLGEDGTLQGLFKLLNKPYVGAPLRGHAVSFDKVLTKELLTVNNIRNTKYIVVDEKTAKTLTWAQVVKDLGDVVFVKAANQGSSVGVSRAKTADEFEAALTDSFQYDYKVLIEAAVKGPRELEVGVIGNEDPIVSEIGAHHVPNQGDGDAWYDYNNKFVDNSSVQFEIPANLPDAVTAEVKDMALKAYKVLDLRGEARMDFLLDENNVPYLGEPNTLPGFTNMSLFKRLWDYSDIDNVELVDKLIDYGFAEFEKNAQLSYEFVSLGEEKIGKFN
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.