PharMolix/UniProtQA huggingface dataset:
Protein: H32_EUPES
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.2.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SHRPN_BOVIN
Sequence: MAPPAGGTAAGSDPGSAAVLLAVHVAVRPLGAGLDVAAQPRRLQLSADPERPGRFRLEMLGAGPGAVILEWPLESVSYTVRGPCQHELQPPPGGPGTLSLHFANPQEAQRWAALVRDATVEGQNGSDSLPPALGPETRPVSPPSPLEVPTPKAPKPKVDLPWSPGDLMEKEELAGRLTRAVEGGDEKGAAQAAAILAQRHVALRVQLQEAYFPPGPIRLQVTVEDAASSAHVSLQVHPHCTIRALQEQVFSEFGFPPAVQRWVIGRCLCVPEHSLAFYGVQRDGDPAFLYLLSAPREAPGRSPQRPQKVDGELGRLFPQSLGLPPTPQPTSSSLPSPLQPGWPCPSCTFINAPSRPGCEMCSTQRPCAWDPLPTASIQQLPKVTRREDGPSLPGPRSLDPLLNLSGNLC
What is the function of this protein?
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation.  LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways.  Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation.  LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex.  The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria.  LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin.  The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation.  Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
What are the official names of this protein?
Sharpin, Shank-associated RH domain-interacting protein.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Synapse. Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1.
Protein: PUR5_PYRHO
Sequence: MLTYAQAGVDEEKTAKALRAIIDAARRTFKFRMNKIGEPGDIGHYSALLDFKDFYLAITTDGVGTKILVAEAVNKFDTIGIDMIAMNVNDLICVGAEPVALVDYLAVKEPNEDVFQQIAKGLYEGAKEAGIAIVGGETAVMPDLINGYDLAGTAVGIVEKDKVVTGEKIKPDDIVIGISSSGIHSNGLTLARKLLIPKYGLDYEYNGKKLWEWLLEPTRIYVKPILKLINEVEVHGLAHITGGGLLNLKRLTKYGFELEMPPIDGIFKLIYENGVPLEEMFRVFNMGVGFMVIVPQEEKENALQILNKYYESFELGKVIKEPEKIKVKNYGITL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSA2_EMENI
Sequence: MPQNEYIERWTKQHGKRLDHDERVRKREARQSHQQSKDAQNLRGLRAKLYQQKRHAEKIQMRKRIKAQEEKNVKSSAPSEPSKTPLPQYLLDRSEATNAKALSSAIKDKRAEKAAKFAVPLPKVKGISEEEMFKVVNTGKKTHKKSWKRMITKPTFVGNDFTRRPVKYERFIRPMGLRYKKANVTHPEMAVTVQLPILSVKKNPQNPLYTQLGVLTKGTVIEVNVSELGIVTAGGKVAWGKYAQITNTPENDGCVNAVLLV
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  May play a part in the quality control of pre-60S particles (By similarity).
What are the official names of this protein?
Ribosome biogenesis protein nsa2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: 3MGH_PARP8
Sequence: MANTMLSLVPLHRNDLPVDTVDLARFLLGKYLVHDLPEGRVAGRIVETEAYPVGDSTNHAYPGRRACNGSMFLEHGHAYVRLTYGIYHVINVVSEPEGTGAAVLIRALEPVAGMEWMQARRPGTTPGDLTRGPGRLALALGVGPGFDGADLCTGRGLWLGAAGRARTPPPFAVTTRIGIARETHRLLRFYVPGSPFVSGPRKLLTGEAPRPG
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: UXAC_STREM
Sequence: MAFNDDNFMLKNEAAKRLYQQIKDQPIFDYHCHLDPKEIFEDKVYDNIVDLWLGGDHYKWRLMRANGISEEEITGSASKLDKFKAFARTLQRSYGNPVYHWSVMELKNVFGVCELLTEDNAEEIYHRINAYLVEHQISPRKLIADSRVRFIGTTDHPLDDLAWHKRLTADDTFETVVAPTFRPDEAFIEHQRFADFVARLAQATGRTITDFKSFIAAMEERIAYFAENGCKASDISFTEIVFEAAEPEQLDRLMTRVLEGYQPQPLEIKQWQTAVFAELCRLYKHYGFVTQVHFGALRNNHSAIFNKLGADVGVDSLGDQAALAINMNRLLDHLVQRDSLPKMIWYNLNPSYNITVPNTLANFQANENGIAGYLQFGAGWWFADTKLGMISQMNALAEQGLLANFVGMLTDSRSFLSYQRHDYFRRILSTYLGEWIEEGEVPEDYQVLGSMAKDIAYNNAIQYFS
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: Y603_HAEIN
Sequence: MAKEQPNDLTEQLTDTPKTAVEQAETMQSVPQTIVKKTGTALSLLAILVALGIGGAGYYFGQQQMAKIQQKLTALENQTGANLSSNNTNNNKRLTQLEQSLKTAQENIAQLEQLIVSKTGEITSLQTQMKQVSQLAIAQQPSDWLFSEADFLLNNALRKLVLDNDVDTAVSLLKLADETLVKVNNSQANEIRSAINQDLKQLLSLSSVDQNAIMQKLSQLANTVDELQRL
What are the official names of this protein?
Uncharacterized protein HI_0603.
What is the protein family that this protein belongs to?
To E.coli HemX N-terminal region.
Protein: LGT_STAAW
Sequence: MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYVENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEKLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS11_XANOP
Sequence: MAKPVEKKTKKKIKRVITDGVAHVHASFNNTIVTITDRQGNALSWATSGGAGFRGSRKSTPFAAQVAAEKAGRAALDYGVKSLEVRIKGPGPGRESAVRSLNNVGYKITNIIDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: XP2_XENLA
Sequence: MNHKLFCVHFLLLILSVCYIQGQDAGGEPAPAEGVAPAPAEGGAPAPAPAEGEAPAPAEGGAPAPAPAEGAEPAPADGGAPAPAPAEGGAPAPAPAEGGAPAPAPAEGGAPAPAEGGAPAPAPAEGEAPAPAPAEGEAPAPAPAEGEAPAPAEGEAPAPAPAEVEAPAPAPAEGEAPAPAPAEGEAPAPAPAEGEAPAPAPAEGEAPAPAPAPAEGEAPAPAPAEGEAPAPAPAEGEAPAPAPAEGEAPAPAPAEGEAPAPAPAEGEAPAPAPAEGEAPAPAPAEGEAPAPAEGEAPAPAPAEGEAPAPAPAEGGAPSPAEGGAPAAAPAEGGAPAPAPAPVEVGPKTEDCKGDPFKRTDCGYPGITEGQCKAKGCCFDSSIVGVKWCFFPRTARAQCLFSPGDREDCGYSSITPMECMKRGCCFDASITGVKWCFHQK
What is the function of this protein?
May act as a growth factor in the germinal layer of the epidermis.  May also be involved in growth of regenerating glands and in protection of the skin from the external environment.
What are the official names of this protein?
Skin secretory protein xP2, Protein APEG.
What are the subcellular locations of this protein?
Secreted.
Protein: PAX_I02A6
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERSESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFIPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFVNPREAKRQLKKNLKSLEPCADLPTKVSHRTSPALKTLEPMWMDSNRTAALRASFLKCQKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: RB12B_HUMAN
Sequence: MAVVIRLLGLPFIAGPVDIRHFFTGLTIPDGGVHIIGGEIGEAFIIFATDEDARRAISRSGGFIKDSSVELFLSSKAEMQKTIEMKRTDRVGRGRPGSGTSGVDSLSNFIESVKEEASNSGYGSSINQDAGFHTNGTGHGNLRPRKTRPLKAENPYLFLRGLPYLVNEDDVRVFFSGLCVDGVIFLKHHDGRNNGDAIVKFASCVDASGGLKCHRSFMGSRFIEVMQGSEQQWIEFGGNAVKEGDVLRRSEEHSPPRGINDRHFRKRSHSKSPRRTRSRSPLGFYVHLKNLSLSIDERDLRNFFRGTDLTDEQIRFLYKDENRTRYAFVMFKTLKDYNTALSLHKTVLQYRPVHIDPISRKQMLKFIARYEKKRSGSLERDRPGHVSQKYSQEGNSGQKLCIYIRNFPFDVTKVEVQKFFADFLLAEDDIYLLYDDKGVGLGEALVKFKSEEQAMKAERLNRRRFLGTEVLLRLISEAQIQEFGVNFSVMSSEKMQARSQSRERGDHSHLFDSKDPPIYSVGAFENFRHQLEDLRQLDNFKHPQRDFRQPDRHPPEDFRHSSEDFRFPPEDFRHSPEDFRRPREEDFRRPSEEDFRRPWEEDFRRPPEDDFRHPREEDWRRPLEEDWRRPLEEDFRRSPTEDFRQLPEEDFRQPPEEDLRWLPEEDFRRPPEEDWRRPPEEDFRRPLQGEWRRPPEDDFRRPPEEDFRHSPEEDFRQSPQEHFRRPPQEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPQEHFRRPPQEHFRRSREEDFRHPPDEDFRGPPDEDFRHPPDEDFRSPQEEDFRCPSDEDFRQLPEEDLREAPEEDPRLPDNFRPPGEDFRSPPDDFRSHRPFVNFGRPEGGKFDFGKHNMGSFPEGRFMPDPKINCGSGRVTPIKIMNLPFKANVNEILDFFHGYRIIPDSVSIQYNEQGLPTGEAIVAMINYNEAMAAIKDLNDRPVGPRKVKLTLL
What are the official names of this protein?
RNA-binding protein 12B, RNA-binding motif protein 12B.
Protein: RPOA_BACAH
Sequence: MIEIEKPKIETVELNEDAKYGKFVIEPLERGYGTTLGNSLRRILLSSLPGAAVTAIQIDGVLHEFSTVEGVVEDVTTIILNLKKLALKIYSEEEKTLEIDVQGEGIVTAADITHDSDVEILNPDLHIATLAKDAHFRVRLTAKRGRGYTPADANKSEDQPIGVIPIDSIYTPVSRVTYQVEKTRVGQVANYDKLTLDVWTDGSIGPKEAISLGAKILTEHLNIFVGLTDEAQNAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQELANKTEEDMMKVRNLGRKSLEEVKHKLEELGLGLRKDD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: PANB_GLOVI
Sequence: MGLSIHSLRKLKERAQPIVALTATEYAMARILDQAGVDLLLVGDSLSMVALGHTSTLPVTVDELLHHCRAVRRGVERALLVADLPFGSYEQSPQQAFSTATRFLKEAGVQAVKLEGGYPRMTETVAFLTESGIPVLGHLGLTPQAVHQLGGYRVQGKTAQAAERLIDQALALEGAGAFALVLEHIPYDLAGEISGKLVIPTVGIGAGPHCNGQILVTHDLLGLTENPPPFVNPYADLRALISKAVGRYSADVRAHGSREE
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_RICPU
Sequence: MNIKDIGVIIAKKPLKENTFIITVFTKNHGLYSGVVKEFSKKSKFIYQEGNIIDFLWQARLHEHIGMAKCELIKSYTGYFITNKAKLYAFNSVISLIKELFHEREEHSKFFLFLINYLDNLSKNFCFRDYINFELALLAETGYKLDLTKCGVSHVTTDLIYVSPKSARALSYEVGKPYKDKLLMLPRFLLSDNSEITLEEKRQALALTNYFFNRYLFHNNRQVEARQTFIEYTLNNF
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: C76BA_SWEMU
Sequence: MDFDFLTIAIGFLFTITLYQALNFFSRKSKNLPPGPSPLPLIGNLHLLGDQPHKSLAKLAKKHGPIMGLQLGQVTTIVVTSSGMAKEVLQKQDLAFSSRSIPNAIHAHDQYKYSVIWLPVASRWRGLRKALNSNMFSGNRLDANQHLRSRKVQELIAYCRKSSQTGDAIDVGRAAFRTSLNLLSNTMFSKDLTDPYSDSAKEFKDLVWNVMVEAGKPNLVDYFPLLDKVDPQGIRKRMTIHFGKILELFGGLIDERLQQKKAKGVNDDVLDVLLTTSEESPEEIDRTHIQRMCLDLFVAGTDTTSSTLEWAMSEMLKNPEKMKAAQAELAQVIGKGKAVEEADLARLPYLRCAIKETLRIHPPVPLLIPRRTEQEVEVCGYTVPKNSQVLVNVWAISRDDAIWKDPLSFKPERFLESELEMRGKDFELIPFGAGRRICPGLPLAVRMVPVMLGSLLNSFDWKLEGGIAPKDLDMEEKFGITLQKAHPLRAVATPL
What is the function of this protein?
Hydroxylase involved in the biosynthesis of hydroxygeraniol, a precursor of the iridoid monoterpenoid swertiamarin.
What are the official names of this protein?
Geraniol 8-hydroxylase, Cytochrome P450 76B10, Geraniol 10-hydroxylase, SmG10H.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: NU4LM_BALOM
Sequence: MTLIHMNILMAFSMSLVGLLMYRSHLMSALLCLEGMMLSLFILAALTILNSHFTLANMMPIILLVFAACEAAIGLALLVMVSNTYGTDYVQSLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PHF14_DANRE
Sequence: MDRGSKRRQVKPLADSLLDALDYDSSDDSDFKVGESSGSEGTGNGSDEEGSKESAAGSESDSDAAAASADEEGIDDLETKDLNQEDDEEEKVKESFSEETSSKETGGSSRSRKKGEKSSDMEPNGSATTEENSAEPKKWNLRRNRPMLDFTTMEELNEMDDYDSEDDNDWRPTQGKKKGKASSGKEKEGSGEEDDDDDDGGSDEEDNEDDNDDDDDDDDEGNDDESSSSDSEEEGKKPKKKAGKNTGAFDEEETNDSHSTSHGKGNEDSLLERPQTWSSQRMEHILICCVCLGDNSEDADEIIQCDNCGVTVHEGCYGVDGESDSIMSSASENSTEPWFCDACKNGVSPSCELCPSQDGIFKETDAGRWVHVVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSLCEDTRFARTGVCISCDAGMCRSFFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRFDRKWKRKNYLALQSYCKVSLQEREKQLTPEAQARITTRLQQYRAKAELSRNTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDTSDISASVDGRRKHKQPALTADFVNYYLERNMRMIQIQDNIVEQKNLKDKLESEQEKLHMEYDKLCESLEDLQNVNGQLRTEGQSIWSMMGGIVGQKLNVPAVLKAPKERKPSKKEGGSPGKSSSLPAMLYSCGICKKNQDQHLLLLCDTCKLHYHLGCLDPPLTRMPKKTKNSYWQCSECDQASSDEADIAMETLPDGTKRSRRQIKGPIKFIPQEMSPEPKKPQVRGTRTRGQKRKRMSICEEEKMEEPLPRERRQRQSTLQKKPKADDTRTECTTCKGPGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDTSSSKEEEAQEVEEESVNEETAEQEIPD
What is the function of this protein?
Histone-binding protein (PubMed:34365506).  Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (PubMed:34365506).  Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity).
What are the official names of this protein?
PHD finger protein 14.
Protein: MINC_BURM9
Sequence: MSLKKSPFFELRSGSVDTLLFIVKTADLDALRAELVKRFEATPEFFADDVVAIDVRRLADHERVPLDDIRGMLNDVRMRVIGVVAQPEQHAWAASAGLPLLEARDRRAPSSKAADEAPVQQAEPAAPAAGQAALFEQAGPTLADAGAPPESPAPAVAAQSATLVVDRPLHSGQQIYAKGDLVVLGPVSYGAEVIAEGNIHIYAPLRGRALAGVHGNHDARIFCTCLEPELISIAGIYRTTENPLPADVLGKSVQIRLEQEKLMIEPLRLT
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: H2A11_CYRHA
Sequence: MKVTLIAILTCAAVLVLHTTAAEELEESQLMEVGMPDTELAAVDGERLFECSVSCEIEKEGNKDCKKKKCKGGWKCKFNMCVKV
What is the function of this protein?
Postsynaptic neurotoxin.
What are the official names of this protein?
U4-theraphotoxin-Hhn1a, U4-TRTX-Hhn1a, Hainantoxin-II.11, HNTX-II.11, Peptide F8-20.15.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HMP_RHOBA
Sequence: MLSEKTIRIVKEITPLVAANAETITRRFYERMFEANPEVKAFFNQAHQHSGGQQKALAGAICAYFTHIDNPAVLMPAVELIAQKHVSLGIKPEHYPIVGSNLLAAIGDVMGDAATPEIVEAVSEAYGFLADIFIGREGAIYEEQASMPGGWNGTRTFVVTKKVRESEIVTSFYLKPEDEGPLPPFKPGQYITVHMDHPHTPTSPRNYSLSDCASQPHYRISVKREERLVPDAPDGLISNHLHDGIEEGHRIELGPPCGEFTVDPATIAKPIVLIAGGIGVTPLLSMAKSIVHANPNAELHFIQAARNSKVHAFADELRRLAQAGPNVHTKVIYDSPLPGDVEEGKCDEAGFVTENQIRESTPFTDADFYFCGPKPFMKNVHSCLRELGVDEHRVRYEFFGPKEELVAV
What are the official names of this protein?
Flavohemoprotein, Flavohemoglobin, Hemoglobin-like protein, Nitric oxide dioxygenase, NO oxygenase, NOD.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: APT_SHIFL
Sequence: MTATAQQLEYLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIDLLVERYKNAGITKVVGTEARGFLFGAPVALGLGVGFVPVRKPGKLPRETISENYDLEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVADAAFIINLFDLGGEQRLEKQGITSYSLVPFPGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACADV_RAT
Sequence: MQSARMTPSVGRQLLRLGARSSRSAALQGQPRPTSAQRLYASEATQAVLEKPETLSSDASTREKPARAESKSFAVGMFKGQLTTDQVFPYPSVLNEGQTQFLKELVGPVARFFEEVNDPAKNDSLEKVEEDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRVASGQALAAFCLTEPSSGSDVASIRSSAVPSPCGKYYTLNGSKIWISNGGLADIFTVFAKTPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPAENVLGEVGDGFKVAVNILNNGRFGMAATLAGTMKAIIAKAVDHATNRTQFGDKIHNFGVIQEKLARMAILQYVTESMAYMLSANMDQGFKDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGTNDILRLFVALQGCMDKGKELTGLGNALKNPLGNVGLLIGEASKQLRRRTGIGSGLSLSGIVHPELSRSGELAVQALEQFATVVEAKLMKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASLQSNPQQQELFRNFRSISKAMVENGGLVTSNPLRV
What is the function of this protein?
Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:8034667, PubMed:1730632).  The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:8034667, PubMed:1730632).  Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:1730632).
What are the official names of this protein?
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial, VLCAD.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.
Protein: GUAA_FRATT
Sequence: MTDIHNHKILILDFGSQYTQLIARRVREVGVFCEIFPHDVAADFIKNYQAKGIILSGGPESVYDSDVKAPEIVFELGVPVLGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNSTNNIFSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVAHKNKPFFGVQFHPETTHTENGKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQAIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRKIIGKLFVDIFDEEAAKIENAKWLAQGTIYSDVIESAGNNQSKAHVIKSHHNVGGLPKEMKLKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLGVRILGEIKKEYVETLQKADAIFTEELYKHNLYHDVSQAFGVFLPVKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLPYDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: DCK_HUMAN
Sequence: MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
What is the function of this protein?
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893, PubMed:20637175).  Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate.  It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).
What are the official names of this protein?
Deoxycytidine kinase, dCK, Deoxyadenosine kinase, Deoxyguanosine kinase.
What is the protein family that this protein belongs to?
Belongs to the DCK/DGK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CXXC1_MOUSE
Sequence: MEGDGSDLEPPDAGDDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKCRERDGSERAGSEPRDEGGGRKRPASDPELQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHHQQQQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSEALPRPRRPPPTQQQPQQSQKLGRIREDEGTVLSSVVKEPPEATATPEPLSDEDLALDPDLYQDFCAGAFDDHGLPWMSDAEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRAAQPGSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEENNENDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADEVCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSSADR
What is the function of this protein?
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
What are the official names of this protein?
CXXC-type zinc finger protein 1, CpG-binding protein, PHD finger and CXXC domain-containing protein 1.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes (By similarity).
Protein: LOK1_LOCMI
Sequence: AFSSWG
What is the function of this protein?
Myotropic peptide.  May be important in the stimulation of ion transport and inhibition of diuretic activity in Malpighian tubules.
What are the official names of this protein?
Locustakinin-1, Locustakinin I.
What are the subcellular locations of this protein?
Secreted.
Protein: RL23A_TETTS
Sequence: MNKENKTQAVNKAKNTAKVAKKGSSITKHKTYTGVRFFRPKTLQLAKAPKYSRTVRAHLKVSGHLDNHSVVKTPLTTEKAMKKMEDENTMVFYVHNRSTKPQIKSAFEKLYNVKVRSVNTLNTITGNKKAYIRLAADSDSLTLANKIGLI
What are the official names of this protein?
60S ribosomal protein L23A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RL19_AQUAE
Sequence: MSSELLRKIEQKYLPKKEYPDFRVGYTVRVYYKIKEGDKERIQPFEGVVIRIRGSGAGKTFTVRRESFGVGIERTFPYYSPNIEKIEVVKIGKVRRAKLYYLRELKGKEAERKIKEIKQWEYEAMQRRKEEARKQREEEQKQAQEQAQEQEQNA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.