PharMolix/UniProtQA huggingface dataset:
Protein: EFG_NOCSJ
Sequence: MAVDITTDLNKVRNIGIMAHIDAGKTTTTERILFYTGITYKIGEVHEGAATMDWMEQEQERGITITSAATTCWWKDHQINIIDTPGHVDFTAEVERSLRVLDGAVAVFDGVAGVEPQTMTVWRQANKYAVPRMCFVNKLDRTGADFFRCVDMMVERLNSTPLVLQLPIGAESDFLGVVDLVGMRALTWRGETKMGEDYEVEEIPAELAEQAAEYREKLLETLSEADDDVMEKYLEGEDFTVEELEAAIRRATLADKVNPVLCGTAFKNKGVQPLLDAVVKFLPSPLDIGEIIGHSVKDENEKVSRKPADSEPFSGLAYKIASDPHLGKLIYIRVYSGKLEAGSTVVNSVNGRKERIGKVYQMHANKREEIASVGAGQIVAVMGLKDTKTGHTLSDPQHQVVLESMTFPAPVIEVAIEPKTKSDQEKLGTAIQRLSDEDPTFTVKSDEETGQTIIAGMGELHLEILVDRMRREFRVEATVGKPQVAYRETIRRKVENHSYTHKKQTGGSGQFAKVIISLEPSIDPETNTGAGYEFVNNVSGGRVPREYIPSVDQGAQEAMEFGVLAGYPMVDVKVTLEDGAYHDVDSSELAFKIAGNQAFKEAARQAKPVLLEPMFAVEVTTPETFLGTVIGDINSRRGHIQAQEERHGDMVISALVPLSEMFGYVGDLRSKTSGQASYSMEFDSYAEVPQGIADEIIKKVRGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_OLEA2
Sequence: MSNVVIMGAQWGDEGKGKIVDLLSREIDVIVRFQGGNNAGHTVIVGDKSYILHLIPSGILHEGKTCLIGNGVVLDPVVFWKEVEALAERGIDVGPQRLMISRKAHVIMPYHKALDVAREDFKNKESRIGTTGRGIGPCYEDKMSRIGVRAGDLADPALLRSKIEAALVEKNALFTALYGREAMSVDAVFDEVMAVGGRLVPYLTDVSSVIEDAWANDSGVMFEGAQGTHLDIDHGTYPFVTSSNTVAGNAAAGSGIPASRLDRVVAIVKAYTTRVGAGPFPTELDDEAGNHMQSVGHEFGATTGRKRRCGWLDCALLRESVRLNGPTDIALTKLDVMSGLKELKICVAYEYNGQRLQHPPQEQNGLAHVTPVYETMPGWDDDITAAKTWEDLPEAARNYICRIEELLGVPVSMISVGPERDQTLNRK
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_RHOBA
Sequence: MGIRIYKPTSAGRRNASVSDFKELTPGYTPERSLLRPKTKTGGRNNQGKITSRHRGGGHKQKYRVIDFRRVKDGVVATVDSVQYDPNRTARIALLKYPDGEKHYVIAPSGVAAGDKLQNGPDAPPVVGNCLPLKNIPLGTSVCCIEMRAGRGAVMCRSAGTQATLQAREADWAQLLLPSGEVRRVPSACRATIGQVGNSDHMNIVLGKAGRSRWLGRRPHVRGTAMNPIDHPHGGGEGRTKGGRHPVSPSGKSAKGGRTRQKRKPSNSSIVRRRKSRRYGQLKLHK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RF1_MYCSK
Sequence: MSAPTTAIDALLAEHADLERQLADPALHADAGKARKAGRRFAQLAPIVATYRKLEAARGDLEAARELGADDASFAAEVPELEATVDQLETQLSDLLAPRDPHDADDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWSVTILDETTSDLGGYKDATLSIRSKGDSADGVWSRLKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVEQVQIDESDLRIDVYRSSGKGGQGVNTTDSAVRITHLPTGIVVTCQNERSQLQNKARAMQVLAARLQSLAEEQASADASADRASQIRTVDRSERIRTYNFPENRIADHRINFKAHNLDQVLDGDLDPLFDALAAADKQARLQSS
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIMK2_BOVIN
Sequence: MAAQAGDDAWRCQGCGDYVAPNQRLYRTVSEAWPTSCFRCSECQDSLTNWYYEKDGKLYCHKDYWGKFGEFCHGCSLLMTGPVMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQDQLPYSVTHISMPATTEGRRGFSVSVESACSNYATTVQVREVNRMHISPNNRNAIHPGDRILEINGAPVRTLRVEEVEDAISQTTQTLQLLIEHDPVSQRLDQLQLDARLSPCAQNDRHAHTLSPLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLLSRDISRSESLRCSSSCSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMNELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNVDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPEECPPAFFPLAAICCRLEPESRPAFSKLEDFFEALSLYLGELGIPLPTELEDLDHTVSMEYGLIRNPPP
What is the function of this protein?
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics.  Acts downstream of several Rho family GTPase signal transduction pathways.  Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP.  Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.  Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity).
What are the official names of this protein?
LIM domain kinase 2, LIMK-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: MUTS_ENTFA
Sequence: MPQKTKNTPMMEQYLSIKAQYKDAFLFYRLGDFYELFYEDAINAAQILELTLTSRNRNADDPIPMCGVPYHAAQGYIDTLIEQGYKVAICEQVEDPKTTKGMVKREVVQLVTPGTVMNSKGLEAKDNNYLTAVLTDGNQFGFAYVDLSTGELKTAVLADEEGVLNEASALQTKEMVLGSGIPESLKENLSLRLNIIFSTQETVEENAEFSFLTNELINPLEIEITGKLLSYLSVTQKRSLSHIQKAVEYQPDHFLKMDHYSKFNLELSQSIRTGQKKGTLLWLLDETKTAMGGRLLKQWLDRPLIQERQIKARQEMVQSLLNAYFERLDLQAALTNVYDLERLAGRVAFGSVNGRDLIQLRTSLEQVPTIRQLIVGINQGEWDDLLVDLNPVEDLVALIATAINEEAPLQITEGKVIKDGYNDQLDEYRDAMRNGKQWLAELEAKERQETGIKNLKIGYNRVFGYFIEITKSNLANLEEGKYERKQTLANAERFITPELKELERLILEAEEKSVELEYQLFLAVREQVKTNIDRLQTLAKTISAVDVLQSFATISERYQYVRPTLRSNTKNLAIVEGRHPVVEKVLGHQEYIPNSIRMNPETDILLITGPNMSGKSTYMRQLALTVVMAQIGCFVPAESAEMPIFDQIFTRIGASDDLIAGQSTFMVEMMEANQALRHATPNSLILFDELGRGTATYDGMALAQAIIEYIHREVQAKTLFSTHYHELTVLDETLKGLKNIHVGAVEKDGEVVFLHKMMEGPADKSYGIHVAKIAGLPSPLLERAATILSALEAEETTIPISVHHEEVSEVHEETEQLSLFKEVSTEELSVIDTLKKMNLLEMTPLDALNMLHQLQKRI
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: PRTM_ALKCK
Sequence: MKKPLGKIVASTALLISVAFSSSIASAAEEAKEKYLIGFNEQEAVSEFVEQIEANDDVAILSEEEEVEIELLHEFETIPVLSVELSPEDVDALELDPTISYIEEDAEVTTMAQSVPWGISRVQAPAAHNRGLTGSGVKVAVLDTGISTHPDLNIRGGASFVPGEPSTQDGNGHGTHVAGTIAALNNSIGVLGVAPSAELYAVKVLGASGSGSVSSIAQGLEWAGNNGMHVANLSLGSPSPSATLEQAVNSATSRGVLVVAASGNSGAGSISYPARYANAMAVGATDQNNNRASFSQYGAGLDIVAPGVNVQSTYPGSTYASLNGTSMATPHVAGVAALVKQKNPSWSNVQIRNHLKNTATGLGNTNLYGSGLVNAEAATR
What is the function of this protein?
Alkaline serine protease that cleaves various substrates, including N-succinyl-Ala-Ala-Pro-Phe-pNA, N-succinyl-Ala-Ala-Pro-MetpNA, oxidized insulin B chain, casein, hemoglobin and scleroproteins, such as keratin, alpha-keratin and elastin.
What are the official names of this protein?
M-protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACSA_PARP8
Sequence: MSAIESVLQERRVFQPSAEVAAQATVSGMDAYKALVAEAERDYEGFWGRLARETLSWNKPFTKVLDESNAPFYKWYDDGELNASYNSIDRHVEAGNGERVAIIFEADDGTITNVTYNDLLQRVSRFANALKQRGIKKGDRVVIYMPMSVEGIVAMQACARIGATHSVVFGGFSSKSLNERLVDVGAVALVTSDEQMRGGKALPLKNIADEALAMGGCEAVKSVIVYQRTGGKIGWDDKRDLWMHEITASESDHCPPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWVTGHSYITYGPLTLGGTQVVFEGVPTYPNAGRFWDMIQKHKVTVFYTAPTAIRSLIKAAEADPKVHPKSYDLSTLRIIGTVGEPINPEAWVWYYENVGGSRCPIVDTWWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPWPSMIRTIWGDPERYKKSYFPEELGGTLYLAGDGSVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVANPLVAEAAVVGRPDDTTGEAVCAFVVLKRARPEGEEAAKIAADLRNWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEITQDVSTLENPAILDQLGESR
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: RNC_SODGM
Sequence: MNPILTNRLQKKLGYTFQQHDLLLQALTHRSASSKHNERLEFLGDSILSYVIANALYQRFPRVDEGDMSRMRATLVRGNTLAEMAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIRTVEKLILDWYRSRLDEISPGDKQKDPKTRLQEYLQGRHLPLPTYQVVQVRGEAHDQEFTIHCQVSGLAQPVVGNGSSRRKAEQAAAEQALKLLELE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD1_SALAI
Sequence: MSASNYATERETAEGKVFTVTGGDWDVVVSGTDPINDERIVVNMGPQHPSTHGVLRLVLELEGETVREARSVVGYLHTGIEKNLEFRNWVQGSTFVTRMDYLAPLFNETAYALAVEKLLGIEEQITERATTIRVLMMELNRISSHLVWVATTAMELGAINMMLYGFREREYILEIFELITGLRMNHAYVRPGGVAQDVPDEAIAKIRDFLKLMPKKLEEYEKMLSGQPIWLERTQNVGVLDATGCLALGVTGPVLRSAGLAWDLRKTMPYCGYETYEFDVPTHTDGDVWGRYLVRLAEIRESLKLVEQAVDRLRPGPVMVADRKIAWPAQLAIGVDGMGNSLEHVAKIMGQSMESLIHHFKLVTEGFRVPPGQVYVALEAPRGELGVHAVSDGGTRPYRVHYREPSFVNLQALPAMAEGGLIADVIAGGASLDPVMGGCDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D 1, NADH dehydrogenase I subunit D 1, NDH-1 subunit D 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PPDK_RICBR
Sequence: MKKLIYYFGSNGSDGNASMKDILGNKGAGLAEMSNLKLPIPDGFTITTELCNYFYTHDNSFPKNFRNELRTAVEKLEATTGKVFGSTKNPLLLSVRSGSIVSMPGMMDTILNLGMNDEVCAALGEVCKDKRFALDSYKRFLEMYGATVLSIPSDLFEQIYERHKIQADIYRDSDVTPQLLEKIIEDFKKLHVKYAEKLITDPYEQLESAIKAVLNSWMSNRAVIYRKINNISESSGTAINIQSMVFGNLSKTSATGVIFTRSPSTGEKKLFGEFLINAQGEDIVSGTRTPLPIISDDSNSMKATMPKVFDELSKISETLEKHYLDMQDIEFTIENSKLYILQTRTAKRTAIAAIKIAVQMVEEKLISKEQALMRIDPESLNQLLHTRIDYSKGLTSIADGLPASPGAATGIIVFSPYDAEKLSHHHKVILVRHDTSPEDINGMHVSSGILTIRGGMTSHAAVVARGMGKPCVCGTNNLVIDEKKQTLIAGDLILKQDDIITIDGGTGKVFLGAVPLIQPTFSEESKLILEWADETSKLKIRTNAETVSDALVSVKFGAKGIGLCRSEHMFFDKNKIPLVREMIIAPDIDRRKLAVQKLLPLQTQDFKALFRVMGDKPVNIRLLDPPLHEFLPTTEEDKKNLASSLNLPLSMINQRLHAMHEVNPMLGHRGCRLGICSPEIYQMQVEAIFTAIFELHKEENIECKLELMIPLISNVNEIKKLKGDIYEMIHELEERYEHKFSFSLGTMIELPRAALNSKKIAEEVDYFSFGTNDLTQTTYGISRDDIASFLPYYLEERIFESDPFTTLDEEGVGELIEIAIKRGKSSNPSLKLGACGEHAGHPASIEFFHKMNLDYVSCSPYRIPIARIAAAQAKIKHG
What is the function of this protein?
Catalyzes the reversible phosphorylation of pyruvate and phosphate.
What are the official names of this protein?
Pyruvate, phosphate dikinase, Pyruvate, orthophosphate dikinase.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
Protein: XPO5_HUMAN
Sequence: MAMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCGLRLAEKTQVAIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANGTLNILEEENHIKDALSRIVVEMIKREWPQHWPDMLIELDTLSKQGETQTELVMFILLRLAEDVVTFQTLPPQRRRDIQQTLTQNMERIFSFLLNTLQENVNKYQQVKTDTSQESKAQANCRVGVAALNTLAGYIDWVSMSHITAENCKLLEILCLLLNEQELQLGAAECLLIAVSRKGKLEDRKPLMVLFGDVAMHYILSAAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGKYLESFLAFTTHPSQFLRSSTQMTWGALFRHEILSRDPLLLAIIPKYLRASMTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQQGEVMRLACRLDPKTSFQMAGEWLKYQLSTFLDAGSVNSCSAVGTGEGSLCSVFSPSFVQWEAMTLFLESVITQMFRTLNREEIPVNDGIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRPEFLPQVFSKLFSSVTFETVEESKAPRTRAVRNVRRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQLLSNELLLTQMEKCALMEALVLISNQFKNYERQKVFLEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKSCDPGLEDPCGLNRARMSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQILKLLDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGLPQPLLELNDSPVFKTVLERMQRFFSTLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQLVRMLTREVMDLITVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKGLQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQKVADKRRKDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSLFKKTKPMLETEVLDNDGGGLATIFEP
What is the function of this protein?
(Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA.
What are the official names of this protein?
Exportin-5, Exp5, Ran-binding protein 21.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
Protein: NTPPA_CUPMC
Sequence: MTSILYLASQSPRRRELLTQLGVTYELLLADAGEDAEALEAVRPGESPDDYVQRVCALKADAALQRRARRGLPDAPILTSDTTVCRGGDILGKPADARDAAAMLASLSGTTHRVLTAVTVATSAGQRHALSISHVTFRPILAPEIERYVASGEPLGKAGAYGIQGRAAEFVERIDGSYSGIMGLPLFETAALLREAGLHF
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLK4_DROPS
Sequence: MMSTRTFGETIEEYEVQHLLGKGGFASVYKARCLHSHQDVAIKMIDKKLIQGTGLTSRVRQEVEIHSRLKHPSVLQLYTFFQDVNYVYLVLELAHNGELQRYMKQHLLRPFTESEGATILRQVVAGLLYLHSHNIMHRDISLSNLLLSKEMHIKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRLSHGLPADVWSVGCMLYTLLVGRPPFETEGVESTLNKVVMSEFMMPSHLSFEAQDLIHKLLKKSPHERITLEQVLRHPFLKRTVGGSSYSTTPGALNEFSQSLASSDSGIVTFASSDSRKSHRLRSVDNSSGQSMPQIMEEYLPSSNLGYDSKEHRPVYEQHGSYLPTPGDQLENRDAKWPGTNNLAPFTSDSDMIPSPVGEKRLLMPPLETKRLQPTRYKTKNAIMSILRTGEVVLEFVKFKVKYNEDRITDICRISEDGRRIIIYQPDPGRGLPIREHPPDPLIPSENCVYNYENLPNKHWKKYVYAARFVGLVKSKTPKITFFSSLGKCQLMETMTDFEVRFYSGAKLLKSSTDGVKVFNSNGAVLSDNGCAEARNLIDHGNECFSHCVNISNALELAQTKENTCFPVTIGRRPAADMHAGQRFDGLRDTTNFAYSTPKSNQGSINFSVSTISTTRSASDYNSNTPRLNMLAAHQNVPIKRITVPEIGIVTELSHGVVQVQFYDGSMVSVIPKVQGGGITYTQANGLSTHFGNNDDLPFAVRDRINQMPQLQMKLKCAPLLGNARSVDCHLMTPKTTTPFYNRMII
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.  Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase SAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: SYC_RICTY
Sequence: MQLHLYNTLTRTKEVFNPQDHANVKMYVCGPTVYDNPHIGNSRSVVVYDLLYRIIIKIFGKKAVKYVRNITDIDDKIIDRAESLGININDLTNKVTREFHINMAYLGCMLPSIEPKATEHIDVMIEIIERLIAQDHAYITDNHVYFDVLSAPNYTELSNRNLEEMFEGVRIENSKTKKNPQDFVLWKPAKQNEPKNVNFSSPWGLGRPGWHIECSAMSYKYLGENFDIHGGGADLIFPHHTNEIAQSRCAFPSSTYAKYWIHNGFLTVNGEKMSKSLGNFITVRDLMDKQIQGEVVRLFLLSSHYRRPLDYNDKAIDDAKKTLDYWYRAIKEINVQKVDLPSDFMQSLFDDMNTPLAIKIINDYAKGVFISKTEAERKFNASAIITCANFIGLMRKTQYEWFNNDIDKLYINELINKRLKAKKQKNWLLADKIRNQLLEKKIILEDKSDCTTIWRKE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_LEGPL
Sequence: MTIILGIDPGSRVTGYGLIKESDRKIAYIDSGCIRTSNDVELSHKLLQIYDGICELMDHYSPTEVAIEQIFMHNNPNSALKLGHARGVAMVAAASHRVKICEYSAREIKQSVVGYGAAEKDQVSHMVVELLQLNRAPQKDAADALAIAICHSHMRNGLSKLIGSRGTKRRRMRL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: LCB2C_ORYSJ
Sequence: MVRVPFVTAVTTVFSYGVIFGFGHLRDWFRALLRSLFSGHSPAAAGTNLKGYAPICGGQEDFYYRRFVRRVQDCFWRPIASKPDAWFDVVERYSNDSNKTLHRTTKTSRCLNLGSYNYLGFAAADEYCTPRVIESLKKYSASTCSVRVDGGNTKLHVELEELVARFVGKPAAILFGMGYVTNSAIIPALIGKGGLIISDSLNHNSIVNGARGSGASVQVFQHNNPAHLEEVLREQIAGGQPRTHRRWKKIIVIVEGIYSMEGELCKLPEIVAVCKKYKAYTYLDEAHSIGAVGKTGRGVCELLGVDPADVDIMMGTFTKSFGSCGGYIAASKEIIDHLKHICPAHIYATSMSPPAVQQVISAIEVILGEDGSDRGAKKLAQIRENSNFFRSELEKMGFEVLGDNDSPVMPIMLYNPAKMPAFSRECLRQKVAIVTVSFPATPLLLARARICISASHSREDLIKGLEVISKVGDLVGIKYLPVEHEKTTSAEKLKKIQ
What is the function of this protein?
Serine palmitoyltransferase (SPT).  The heterodimer formed with LCB1 constitutes the catalytic core (By similarity).
What are the official names of this protein?
Long chain base biosynthesis protein 2c.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: VP2_POVKI
Sequence: MGIFLAVPEIIAASIAGGAEALSIAGSGAAIATGEGLAALGGITEGAALLGETIPISEAATTVLTKVPELVQATQAVTAAVQGGAGLVGGIYTALASDHPGDLPPNTPTGSASGLHPTSGYNPQGAGLNLQSVHKPIHAPYSGMALVPIPEYQLETGIPGIPDWLFNLVASYLPELPSLQDVFNRIAFGIWSSYYNAGSTVVNRVLSDEIQRLLRDLEYGFRATLASIGESDPVNAIATQVRSLASTARERELLQITAGQPLDLSRPTSALSAAAGALTEAAYNFIYDASSLPKDGFNALSEGVHRLGQWISFSGPTGGTPHYATPDWILYVLEQLNADTYKIPTQAVKRKQDELHPVSPTKKANKAKKSSSPGTNSGNRSKKRRGRSTSRSTTVRRNRI
What is the function of this protein?
Structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers.  Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane.  Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2 or VP3 nuclear localization signal (shared C-terminus).  Plays a role in virion assembly within the nucleus.
What are the official names of this protein?
Minor capsid protein VP2, Minor structural protein VP2.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses capsid protein VP2 family.
What are the subcellular locations of this protein?
[Isoform VP2]: Virion. Host endoplasmic reticulum. Host nucleus. Host endoplasmic reticulum membrane. Note=Following host cell entry, the virion enters into the endoplasmic reticulum through a calveolar- dependent pathway. Then, isoform VP2 integrates into the endoplasmic reticulum membrane and participates in the translocation of viral DNA to the nucleus. Shortly after synthesis, a nuclear localization signal directs isoform VP2 to the cell nucleus where virion assembly occurs. SUBCELLULAR LOCATION: [Isoform VP3]: Virion. Host endoplasmic reticulum. Host nucleus. Host endoplasmic reticulum membrane. Note=Following host cell entry, the virion enters into the endoplasmic reticulum through a calveolar- dependent pathway. Then, isoform VP3 integrates into the endoplasmic reticulum membrane and participates in the translocation of viral DNA to the nucleus. Shortly after synthesis, a nuclear localization signal directs isoform VP3 to the cell nucleus where virion assembly occurs.
Protein: AC4CH_ECO7I
Sequence: MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELKKVIADIYPDQTQFYVIEFKCL
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: LAPM5_PONAB
Sequence: MDPRLSAVRQTCCCFNVRIATTALAIYHVIMSVLLFIEHSVEVAHGKASCKLSQMGYLRIADLISSFLLIAMLFIISLSLLIGVVKNREKYLLPFLSLQVMDYLLCLLTLLGSYIELPAYLKLASRSRASPSKFPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEDMPHNQFIKMMIIFSIAFITVLIFKVYMFKCVWRCYRFIKCMNSVEEKRNSKMLQKVVLPSYEEALSLPSKTPEGGPAPPPYSEV
What is the function of this protein?
May have a special functional role during embryogenesis and in adult hematopoietic cells.
What are the official names of this protein?
Lysosomal-associated transmembrane protein 5, Lysosomal-associated multitransmembrane protein 5.
What is the protein family that this protein belongs to?
Belongs to the LAPTM4/LAPTM5 transporter family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.