PharMolix/UniProtQA huggingface dataset:
Protein: HEM6_RHIME
Sequence: MERPQLPQGLPADIEDKKAAAKAWFESLRDTICAAFEAIEDELTGPLSDRPAGRFVAKDWLREEGAGGGGRMSMMEGRVFEKVGVHTSTVFGEFSPEFREQIPGASEDPRFWASGISLIAHPVNPNVPAVHMNTRMVVTTSNWFGGGADLTPVLDRRRIMTDPDTVLFHRAMEIACNRHPVADHAKFKQWCDEYFYLKHRNEPRGTGGIFYDWLRSAEELGGWDADFAFTRDVGKAFALVYPRIVRTNFNKPWTEQDRNEQLVRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPLVRWP
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTER_SALSA
Sequence: MSALSGKVQTVLGPIEPDQLGRTMTHEHLTMTFECCYFSPAPGDETVAQAPIQMKNLFWLKQNPYSSHENLLLLQETNAVREELHEYRKAGGGTIVENTTQGIARDLPCLKQLAKESGVHIIGGAGYYVDATHSEATRKMTVEKLTDIIISEVLHGADGTEIRCGVIGEIGCSWPITDSEKKVLQATAHAQTELGCPVIIHPGRNPGAPAEIVRLLQEAGGDISKTVMSHLDRTIFDNGELLEFAKMGSYLEYDLFGMETLNYAYNLEVDMPSDSQRVKALAFLVQEGYEDNIVIAHDIHTKNRLTKYGGHGYSHILKNIVPKMLKRGINQTQVDKILIDNPKRWLTFK
What are the official names of this protein?
Phosphotriesterase-related protein, Parathion hydrolase-related protein.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
Protein: SYE_STRPM
Sequence: MSKPIRVRYAPSPTGLLHIGNARTALFNYLYARRHGGTFIIRIEDTDRKRHVEDGERSQLENLKWLGMDWDESPETHENYRQSERLALYQQYIDQLLAEGKAYKSYVTEEELAAERERQEAAGETPRYINEFIGMSADEKAKYIAEREAAGIVPTVRLAVNESGIYKWTDMVKGDIEFEGGNIGGDWVIQKKDGYPTYNFAVVVDDHDMQISHVIRGDDHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLSKRDTNTLQFIEDYRKKGYMPEAVFNFIALLGWNPGGEEEIFSREQLIALFDENRLSKSPAAFDQKKMDWMSNEYLKHADFETVYALCKPFLEEAGRLTEKAEKLVELYKPQLKSADEIIPLTDLFFSDFPELTEAEKEVMAGETVSTVLQAFKAKLEAMSDEDFKPENIFPQIKAVQKETGIKGKNLFMPIRIAVSGEMHGPELPNTIYLLGRDKSIEHIKNML
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDCD2_HUMAN
Sequence: MAAAGARPVELGFAESAPAWRLRSEQFPSKVGGRPAWLGAAGLPGPQALACELCGRPLSFLLQVYAPLPGRPDAFHRCIFLFCCREQPCCAGLRVFRNQLPRKNDFYSYEPPSENPPPETGESVCLQLKSGAHLCRVCGCLGPKTCSRCHKAYYCSKEHQTLDWRLGHKQACAQPDHLDHIIPDHNFLFPEFEIVIETEDEIMPEVVEKEDYSEIIGSMGEALEEELDSMAKHESREDKIFQKFKTQIALEPEQILRYGRGIAPIWISGENIPQEKDIPDCPCGAKRILEFQVMPQLLNYLKADRLGKSIDWGILAVFTCAESCSLGTGYTEEFVWKQDVTDTP
What is the function of this protein?
May be a DNA-binding protein with a regulatory function.  May play an important role in cell death and/or in regulation of cell proliferation.
What are the official names of this protein?
Programmed cell death protein 2, Zinc finger MYND domain-containing protein 7, Zinc finger protein Rp-8.
What are the subcellular locations of this protein?
Nucleus.
Protein: ANT1_ASHGO
Sequence: MSFENAVIGATASSLANIAVYPLDLAKTLVQTQLKDEFVEAGEEAGEERAGSRRQNRIKPIALRSPQAAEQYKGALDALQRIYGAEGVAGLYRGLGSSTVAGFIQSFSYFFWYTLVRKHYFRLKQARGGDARFSTPEELVLGIVAAATSQLFVNPINVVATRQQTRGQAAGAADMRTVAREVHAENGWRGFWAGLKVSLVLTVNPSITYATYERLREALFPTPAAASHLVDSAALLSPGQNFVMGVLSKIVSTVLTQPLIIAKASLQRSGSCFQDFHQVLHHLYSTEGPLSLWKGLGPQITKGVLVQGLLFMFKGELTKMLRKLMFYLALLRSSRRALKG
What is the function of this protein?
Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen.  This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol.  Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids (By similarity).
What are the official names of this protein?
Peroxisomal adenine nucleotide transporter 1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: TATA_RICAE
Sequence: MGMSFSHLLIVLLIIFVLFGAGKLPQVMSDLAKGLKAFKDGLKDDGSDNDKNK
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PHY1_PHYPA
Sequence: MSTPKKTYSSTSSAKSKAHSVRVAQTTADAALQAVFEKSGDSGDSFDYSKSVSKSTAESLPSGAVTAYLQRMQRGGLTQSFGCMIAVEGTGFRVIAYSENAPEILDLVPQAVPSVGEMDTLRIGTDVRTLFTASSVASLEKAAEAQEMSLLNPITVNCRRSGKQLYAIAHRIDIGIVIDFEAVKTDDHLVSAAGALQSHKLAAKAITRLQALPGGDIGLLCDTVVEEVRELTGYDRVMAYRFHEDEHGEVVAEIRRADLEPYLGLHYPGTDIPQASRFLFMKNKVRIIADCSAPPVKVIQDPTLRQPVSLAGSTLRSPHGCHAQYMGNMGSIASLVMAVIINDNEEDSHGSVQRGRKLWGLVVCHHTSPRTVPFPLRSACGFLMQVFGLQLNMEVELAAQLREKHILRTQTLLCDMLLRDAPIGIVSQIPNIMDLVKCDGAALYYGKRFWLLGTTPTESQIKDIAEWLLEYHKDSTGLSTDSLADANYPAAHLLGDAVCGMAAAKITAKDFLFWFRSHTAKEIKWGGAKHDPGEKDDGRKMHPRSSFKAFLEVVKRRSLPWEDVEMDAIHSLQLILRGSFQDIDDSDTKTMIHARLNDLKLHDMDELSVVANEMVRLIETATAPILAVDSNGMINGWNAKIAQVTGLPVSEAMGRSLVKDLVTDESVAVVERLLYLALRGEEEQNVEIKLKTFGTQTEKGVVILIVNACSSRDVSENVVGVCFVGQDVTGQKMFMDKFTRIQGDYKTIVQNPHPLIPPIFGADEFGYCFEWNPAMEGLTGWKKDEVVGKLLVGEIFGMQMMCCRMKSQDAMTKFMIALNTAMDGQSTDKFTFSFFDREGKYVDVLLSTNKRTNADGVITGVFCFLQIASSELQQALKVQRATEKVAVAKLKELAYIRQEIKNPLCGITFTRQLLEDTDLSDDQQQFLDTSAVCEQQLQKVLNDMDLESIEDGYLELDTAEFEMGTVMNAVISQGMTTSREKGLQIFRETPREINTMRLLGDQIRLQQVLSDFLLNTVRFTPSPEGWVKIKVVPTRKRLGGSVHVVHLEFRVSHPGAGLPEELVLEMYDRGKGMTQEGLGLNMCRKLVRLMNGDVHYVREAMQCYFVVNVELPMAQRDDASSQM
What is the function of this protein?
Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region.  Photoconversion of Pr to Pfr induces an array of morphogenetic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses.  Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc.  It also controls the expression of its own gene(s) in a negative feedback fashion.  Mediates chloroplast avoidance movement in cytoplasm.
What are the official names of this protein?
Phytochrome 1.
What is the protein family that this protein belongs to?
Belongs to the phytochrome family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAM_CHLVU
Sequence: MPIADSQVFIALFLALATGIFAVRLGVALYK
What are the official names of this protein?
Photosystem I reaction center subunit XII, PSI-M.
What is the protein family that this protein belongs to?
Belongs to the PsaM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FTHS_STRP2
Sequence: MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRRILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQVEGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASIDVPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKSQTQIAQIVQNGWDKLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: YIDD_ANADE
Sequence: MIRRALVLLVRIYQRLVSPLLPPACRFYPSCSAYAVTALQRHGALRGSWLTVRRLCRCHPFHPGGVDPVPELTPKR
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NEF_HV1S2
Sequence: MGNKWSKSWPQVRERMRRAPAPAADGVGAVSQDLAKHGAITSSNTAATNADCAWLEAQTEEEVGFPVKPQIPLRPMTYKGAVDLSFFLKEKGGLDGLIYSKKRQEILDLWVHNTQGYFPDWQNYTPGPGIRYPLTFGWCYKLVPVDPSEVEEANEGENNCLLHPICQHGIEDEEREVLQWKFDSSLARRHIARELHPEFYKDC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: NHAB_YERPN
Sequence: MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGMTSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSVGFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFFIRMLPVTLPVFIFGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQANAKRTKQEKMKLIVQAIIGVWLVLALALHLAEVGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLLSSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMALPYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPPH_AZOC5
Sequence: MTRLEDLPYRPCVGLAIFNRAGQVFLGQRLSGPEHVDATHSWQMPQGGIDKGEEPYEAALRELYEETSIRSVVKLGEVEDWLSYDLPGRVAGEAWKGKYRGQTQKWFALRFTGDEGEIDILKPGGGAHKAEFCNWRWDALDRAAELVIPFKRQVYERVAREFRRFAHD
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: GCH1_MYCLB
Sequence: MALLDLGLESTAVPRIRVFDQQRAEAAIRELLYAIGEDPDREGLADTPARVARACRELFSGLYTDPQTVLNTMFDEEHNELVIVKEIPMYSTCEHHLVSFHGVAHIGYLPGADGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALVSKLDPRGVIIVVEAEHLCMAMRGVRKPGAITTTSAVRGQFKTDAASRAEALGLILRK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: CH60_BUCAI
Sequence: MAAKDVKFGNEARIKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPSITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATLLAQSIVNEGLKAVAAGMNPMDLKRGIDKAVISAVEELKHLSVPCSDSKAITQVGTISANADEKVGSLIAEAMEKVGNDGVITVEEGTGLQDELEVVKGMQFDRGYLSPYFINKPETGIVELENPYILMADKKISNVREMLPILESVAKSGKPLLIISEDLEGEALATLVVNSMRGIVKVAAVKAPGFGDRRKAMLQDISILTGGSVISEELAMELEKSTLEDLGQAKRVVISKDTTTIIGGVGEKHSIQSRISQIRQEIQEATSDYDKEKLNERLAKLSGGVAVLKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALVRVAGKIADLRGQNEDQNVGIRVALRAMEAPLRQIVSNSGEEPSVVTNNVKDGKGNYGYNAATDEYGDMIDFGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKEDKSSDSSSSPAGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_DEIGD
Sequence: MSVVILDFGSQFTRLIARRLRELGAYSVILPGTASLERIAQENPQGIVLSGGPSSVYDANAPRPAPGVLDLDVPILGVCYGMQFLAHEAGGAVQRAGKREYGKADLTRYGGQLFAGIQGEFVAWMSHSDSVTQLPQGYEVIAATEDTPVAGIENTVTRRYGVQFHPEVVHTPKGGQLLANFLEICGVARDWNAEHIVDELIEDVRRQVGAGRVLLAISGGVDSSTLGLLLARAIGDRLTAVFIDHGLLRLGEREQVEAALRPLGVNLVTVDASEEFLGALAGVSDPEQKRKIIGREFIRAFEREARKYGPFDFLAQGTLYPDVIESAGGEGAANIKSHHNVGGLPEDLAFKLVEPFRTLFKDEVREIARLLGLPDAIRMRHPFPGPGLAIRCLGEVTREKLDILKRVDDIFISGLREFGLYDGCSQALAVLTPIQSVGVMGDERTYSYTAALRAVTTDDFMTAEWARLPYEFLATMSNRIVNQVHEINRVVYDITGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RL20_HERAR
Sequence: MPRVKRGVTARARHKKVLDQAKGYRGRRSKVYRIAKQAVMRAGQYAYRDRRNKKRVFRALWITRINAASREHGLTYSVFMNGLKRASIELDRKVLADMAVMDKPAFAAIVNQVKTTIAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PHGR_EUBOX
Sequence: XVPCNKEFVXNXF
What is the function of this protein?
Functions in the pathway of anaerobic degradation of trihydroxybenzenes by catalyzing reduction of the aromatic nucleus prior to ring fission.
What are the official names of this protein?
Phloroglucinol reductase.
Protein: IPAC_SHIFL
Sequence: MEIQNTKPTQTLYTDISTKQTQSSSETQKSQNYQQIAAHIPLNVGKNPVLTTTLNDDQLLKLSEQVQHDSEIIARLTDKKMKDLSEMSHTLTPENTLDISSLSSNAVSLIISVAVLLSALRTAETKLGSQLSLIAFDATKSAAENIVRQGLAALSSSITGAVTQVGITGIGAKKTHSGISDQKGALRKNLATAQSLEKELAGSKLGLNKQIDTNITSPQTNSSTKFLGKNKLAPDNISLSTEHKTSLSSPDISLQDKIDTQRRTYELNTLSAQQKQNIGRATMETSAVAGNISTSGGRYASALEEEEQLISQASSKQAEEASQVSKEASQATNQLIQKLLNIIDSINQSKNSAASQIAGNIRA
What is the function of this protein?
Forms a pore with IpaB, which is inserted into host cell membrane through the Mxi/Spa apparatus, during cell contact.  This pore probably allows the translocation of IpaA.  The C-terminus of IpaC could be involved in actin polymerization that leads to the cell extension formation and its N-terminus could be involved in the conversion of filopodial extensions into lamellipodial extension.  Most extensions results from Cdc42 activation by IpaC whereas the lamellipodial extensions result from the Rac activation by Cdc42.
What are the official names of this protein?
Invasin IpaC, 42 kDa antigen.
What is the protein family that this protein belongs to?
Belongs to the invasin protein C family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted through the specialized type-III secretion system Mxi/Spa. Inserted into the host cell membrane.
Protein: SECY_VIBCH
Sequence: MARKPGQDFRSAQSGLSELKSRLFFVIGALLVFRAGSFVPIPGIDAAVLAELFEQQKGTIVEMFNMFSGGALERASILALGIMPYISASIVVQLLTVVHPALAELKKEGEAGRRKISQYTRYGTLVLATFQAIGIATGLPNMVNNLVVIDQTMFTLIATVSLVTGTMFLMWLGEQITERGIGNGISILIFAGIVAGLPKAIGQTIEQARQGELHVLLLLLIAVLAFAVIYFVVFMERGQRRIVVNYAKRQQGRKVFAAQSTHLPLKINMAGVIPAIFASSIILFPGTLAQWFGQNGESSTFGWLTDVSLALSPGQPLYVMLYAAAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGEQTAKYIDKVMTRLTLAGALYITFICLIPEFMMVAWNVRFYFGGTSLLIVVVVIMDFMAQVQTHLMSHQYESVLKKANLKGYGR
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAD7_HUMAN
Sequence: MAEEEETAALTEKVIRTQRVFINLLDSYSSGNIGKFLSNCVVGASLEEITEEEEEEDENKSAMLEASSTKVKEGTFQIVGTLSKPDSPRPDFAVETYSAISREDLLMRLLECDVIIYNITESSQQMEEAIWAVSALSEEVSHFEKRKLFILLSTVMTWARSKALDPEDSEVPFTEEDYRRRKSHPNFLDHINAEKMVLKFGKKARKFAAYVVAAGLQYGAEGGMLHTFFKMAWLGEIPALPVFGDGTNVIPTIHVLDLAGVIQNVIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGKIQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQTGFVENINTILKEYKQSRGLMPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPEDPVDFLAEYLFKNNPEAQ
What is the function of this protein?
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.  Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP.  Also displays broad nucleoside diphosphate kinase activity.  Involved in maintaining ciliary structure and function.
What are the official names of this protein?
Adenylate kinase 7, AK 7, ATP-AMP transphosphorylase 7.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the dpy-30 family.
Protein: TRMA_PSEFL
Sequence: MVQRMTFDAASYTAQLQDKVTRLRDLLAPFDAPEPQVFDSPLQNFRLRAEFRLWREGGERHYAMFSQDDKRTPILIEEFPIASLRINQLMPQLKAAWQASAALSHKLFQVEFLTTLAGDAMITLCYHRPLDEHWHTAANKLAADLNVSIIGRSKGKRDVIGRDYVVEKLDVGGRTFSYRQPEGAFTQPNGTVNQKMLNWAFEALGDRSDDLLELYCGNGNFTLPLATRVRKVLATEISKTSVNAALSNLDENAVDNVTLVRLSAEELTEALNEVRPFRRLHGIDLKSYEFGSVFVDPPRAGMDPDTCELTRRFENILYISCNPETLAANIAQLHDTHRITQCAMFDQFPWTHHMESGVLLTRR
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: MIC26_MOUSE
Sequence: MFKVIQRSVGPASLSLLTFRVYAAPKKDSPHKSYMKIDELSLYSVPEGQSKYVEEPRTQLEENISQLRHHCEPYTSFCQEIYSHTKPKVDHFVQWGVDNYNYLQNAPPGFFPRLGVIGFAGFVGLLFARGSKIKKLVYPPFFMGLGASVYYPQQAITIAQITGEKLYDWGLRGYIVIEDLWKQNFQKPGNVKNSPGNK
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Plays a crucial role in crista junction formation and mitochondrial function (By similarity).  Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151).  Promotes cholesterol efflux from macrophage cells.  Detected in HDL, LDL and VLDL.  Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (By similarity).
What are the official names of this protein?
MICOS complex subunit Mic26, Apolipoprotein O, MICOS complex subunit Mic23, Protein FAM121B.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion. Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form.
Protein: SYT_META3
Sequence: MKVLLIHSDYLEFEAKQKTKIAEDTDILNGKMEECLTVFMAVEKEDEENPQNVIYNTVDEIIKTAENLKINNVVVYPYAHLSSELSSPKVAKEVLQKIEEELKQKNYSVLRAPFGWYKSFKISCKGHPLSELSRKITTERKEEKGETEAKDRPKNKFYILDGEKGEEGLKELDEKKVKKLKDKGLKSVAMHEMGIKHGGKEKDIEPPHVKFITEKEICDYEPSSDAGHFRWYPKGKLIRDLLQDYVYNMVVENNGMPVETPVMYDLGNKAIKEHADKFGERQYRFKQGNKDLMLRFAACFGQFMMKKDMYILPKHLPLKLYELSTYSFRYEQRGELVGLKRLRGFTMPDMHTVCKDTKQTIEEFENQFWMCLKTGDDLNTPYSTIFRFTEDFFEENKEWFFKVAKEYKEKYGKDVILELIPERKHYWVGKVDMAVIDSFGRPIENPTVQIDVESAKRFNIVVHDGNEKTYPVILHCSPTGSIERVLCGLLEKASLDADAGAPPMLPVWLSPIQARVIPVADAHSEYALSVAKKLRENGIRADFDDREESVGKKIRNAGKDWVPFVIVIGDKEVENNILTTTIREKSTLKKPVKENLTVEELIEKIKEETKGFPYRPLSLPLYCSLQPIFR
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCF11_CAEEL
Sequence: MESVESAARDYRETLAELRNNNKTQINLLTILADDFKKAAPQIVEVIERHLTTCSPSQKLLVMYVCDSILKNVKKPNDYDALFARKIVSMFEHAFRQGDERIRTSLYRIRVTWASTTLFMPSKLYELDMKINKLDPNWPISNPQTGRALRDDPQVMAPSQSRPAGNATSPAASTSTNRVFVNPKFIGSSTPGAASASKTVVEKTKSPGTVNKEKQVKKEPKQDPLDKLLPSSSASKTSSSPAGLKRKSAPSEHPNAPIRKKPQQPPKPQTAIDEDLRSISLTKKPPVPSAQDQDFRPKTLKPTSVIGSHAFAPVAAPIRPMIPVPPPVSVAPFVPAPPLSSAPPFQHPQQHHPQLPPPPVHQGMGRGYHHNSPPQDPAPIVPVQAPPPQQHLPAPENVYSSEQPKLDVPANNRIFVDGKAYEVMFVDDTAVIERGGAPHRIYFAGPPRNLVIDGIPHLLQFDTPTQIDILGSKHMVKFGAPSRELYIGGHPFKGQFGGPPIIATINGRRHEIRLTGSAPEVRIEPEPAYHLTHFLHKMREEKKIEIASEKPEKKEDWLSYLKNLRTRNILPAPARSPSSPRNQTPPPANLPIPGMNNAGQRGGYHNRHQPQQNARWGGANKQQNIPPPPSDPSPIGSGVEKRSAPPAAITDFNIRLLQIRYDSVVDALITKRADACKFCGMRLDDSQGKSKEWQDHMDWHVKQNLARHGSNNSAAVPYRQWYPSTSTWLTPRASDETNEQEADKPEEPLPGVASSGVKTKECSVCGEKFDEYYDDDEETWRLRDTVNVHGKIVHSACASDAARSLDNSSFFNDSDIKKEEPFD
What are the official names of this protein?
Polyadenylation and cleavage factor homolog 11.