PharMolix/UniProtQA huggingface dataset:
Protein: OHK6_ORYSJ
Sequence: MGKPEARSGWRNAAAAAWVLVAVACAAYMHWHLRRETMDRAEERLVSMCEERARMLQEQFGVTVNHVHALAILISTFHFEKFPSAIDQDTFAKYTARTSFERPLLNGVAYAQRIFHHEREMFENQQGWIMKTMKRQAAPPQDEYAPVIFSQDTVSYLARIDMMSGEEDRENILRARATGKAVLTNPFRLLGSNHLGVVLTFAVYRPGLAADASVEERVEATAGYLGGAFDVESLVENLLSKLAGNQDIVVNVYDVTNASEPMAMYGPQSPDGKVSLFHVSTLDFGDPFRAHEMRCRYRQKPPLPWSAITNPLGTFVIWMLVGYIICAAWSRYDKVSEDCRKMEELKTQAEAADVAKSQFLATVSHEIRTPMNGVLGMLDMLLGTDLSMTQKDYAQTAQMCGRALITLINDVLDRAKIEAGKLELEAVPFDLRSLMDDVISLFSSKSREKCIELAVFVCDDVPKVVIGDPWRYRQILTNLVGNAVKFTERGHVFVRVCLAENSKVEANQVLNGTMNGKDGKVETTANGAFNTLSGFQAADERNNWDYFKLLLSDKEPHMDELECDRSYQNDCDCVTLMISIEDTGVGIPLHAQDRVFTPFMQADSSTSRNYGGTGIGLSISKCLAELMGGQISFTSRPFVGSTFTFSAVLKRSCKDTSSDSKRSLSEALPTAFKGMKAILVDGRPVRGAVTRYHLNRLGIVVKVVNNLSMGLQTLAGQNGVKESREKLSMLFIESDIWRPETDILLLNRLHELKNNGQVHELPKLVLLVTSEADKDRYGSAFDIVMYKPIRASTIASCLQQLLKVVMPERKDNQNRPSFLRSLLIGKNILIVDDNKVNLRVAAAALKKYGAKVHCVESGKDAVSLLQQPHCFDACFMDVQMPEMDGFEATRQIRQMEVKANEERKALDLMEGSTFVESHLPVLAMTADVIQATYEECIKSGMDGYVSKPFDEEQLYQAVSRLVVGTKESAV
What is the function of this protein?
Cytokinin receptor related to bacterial two-component regulators.  Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade.
What are the official names of this protein?
Probable histidine kinase 6, OsHK6, OsCRL1a.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TAGH_LACLA
Sequence: MNTNKVKIKAEYLTKKFELLPAKSSKNKAKSLIGSNSKNEKDFWALRNISFEIRDGECVGVIGLNGAGKSTLSNIISGQIAQTTGRVEINGDVSIIAASAGMQNNLSGRENIRLKALMVGLTNKEIKSKMDDIIEFSELGPFIDQPVKTYSSGMKAKLGFSIMVHQNPDIMIIDEGLSVGDKTFVDKSQKKMFEFRDEGKTILLVSHDMRTIKEWCDRVIWLNYGEVKAYGRPEEVIPEYEKFVQWFKKLPKKEQEKFKTDQRQAQLDYSVEELKAEIVSQNPSKSRRVQREVTEELKNKKDNHKLSLMSKVIVWLCLLAFIWITLVSLSNATLAESLRHPKTFFTERLFKSDTRNMTSTTKKEAVVKTSSSPKKKVSQAKKTTKVSSTQKNTSSSSSTSNQNTYIVQAGDSLSIIAENHGYSVEEIQQVNPGVDFSVIHPGQEINLPEPTTSANSTTEQSDGANQ
What is the function of this protein?
Part of the ABC transporter complex TagGH involved in teichoic acids export.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Teichoic acids export ATP-binding protein TagH.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Teichoic acids exporter (TC 3.A.1.104.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL17_GEMAT
Sequence: MRHRKANRQLRRTSEQRLALLRNLATSLIEQGAIETTEAKAKELRPFVEKLITKARTGTLHARRLAGKHVHKREAADKLFQELGPAFATRPGGYTRILKTGHRKGDGAEMARIELILS
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: GCSPB_TREDE
Sequence: MSELIFEKSVKGHKFAEAKLTVPEYKLDSKYLRASDAKLPEVSELEFVRHYMELSKRTHGVDNGFYPLGSCTMKYNPKLNEEVADLPNFTNIHPLQPEHTMKGCIEAMGDLGKKLGEITGMDAFSLQPSAGAHGEFTALLVIRAYHEKRGDHARNKILVPDSAHGTNPASAAMVGCEIVNIPSDKDGNVDIEELKKTVGNDTAALMLTNPNTLGLFETHIKEIAEIVHKAGGLLYYDGANLNAIMGRLRPGDMGYDIVHLNLHKTFSTPHGGGGPGSGPIGCKKFLEEFLPVPVVTGSDGSYKLDYNRPDSIGRVRNFYGNFLVFLRAYAYILTLGSEGIRESSGYAVLNANYLKKKLEKEYDVAFDRICMHEFVLTLEKIKEETGVSALDIAKGLIDDGIHPPTMYFPLIVHEALMFEPTETESKSTLDFTAEVMIKLKKEAYSNPEKLHGYPYTRPIGRVDETKAAREPVLRYKACCCCK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: IL5RA_MOUSE
Sequence: MVPVLLILVGALATLQADLLNHKKFLLLPPVNFTIKATGLAQVLLHWDPNPDQEQRHVDLEYHVKINAPQEDEYDTRKTESKCVTPLHEGFAASVRTILKSSHTTLASSWVSAELKAPPGSPGTSVTNLTCTTHTVVSSHTHLRPYQVSLRCTWLVGKDAPEDTQYFLYYRFGVLTEKCQEYSRDALNRNTACWFPRTFINSKGFEQLAVHINGSSKRAAIKPFDQLFSPLAIDQVNPPRNVTVEIESNSLYIQWEKPLSAFPDHCFNYELKIYNTKNGHIQKEKLIANKFISKIDDVSTYSIQVRAAVSSPCRMPGRWGEWSQPIYVGKERKSLVEWHLIVLPTAACFVLLIFSLICRVCHLWTRLFPPVPAPKSNIKDLPVVTEYEKPSNETKIEVVHCVEEVGFEVMGNSTF
What is the function of this protein?
Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:1873482).  Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5.  In unstimulated conditions, interacts constitutively with JAK2.  Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.
What are the official names of this protein?
Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PDK4_ICTTR
Sequence: MKAARFAMHSARSLSSVGLVPREVELFSRYSPSPLSMKQLLDFGSDNACERTSFSFLRQELPVRLANILKEIDVLPDRLTNTSSVQLVKSWYIQSLMELVEFHEKSPEDQKNLSDFVDTLIKVRNRHHNVVPTMAQGILEYKDTCTVDPVTNQSLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPKCDVVAVIQDAFESSKMLCDQYYLTSPELKLTQVNGKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVERQESWPSLTPVEVIVVLGKEDLTIKISDRGGGVPLRITDRLFSYMYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSEADDWCIPSREPRNLSKEKMAM
What is the function of this protein?
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2.  This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate.  Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation.  Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade.  Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation.  In the fed state, mediates cellular responses to glucose levels and to a high-fat diet.  Regulates both fatty acid oxidation and de novo fatty acid biosynthesis.  Plays a role in the generation of reactive oxygen species.  Protects detached epithelial cells against anoikis.  Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
What are the official names of this protein?
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, Pyruvate dehydrogenase kinase isoform 4.
What is the protein family that this protein belongs to?
Belongs to the PDK/BCKDK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: DEOC_LISIN
Sequence: MTIAKMIDHTALKPDTTKEQILTLTKEAREYGFASVCVNPTWVKLSAEQLSGAESVVCTVIGFPLGANTPEVKAFEVKNAIENGAKEVDMVINIGALKDKDDELVERDIRAVVDAAKGKALVKVIIETCLLTDEEKVRACEIAVKAGTDFVKTSTGFSTGGATAEDIALMRKTVGPNIGVKASGGVRTKEDVEKMIEAGATRIGASAGVAIVSGEKPAKPDNY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IE63_EHV2
Sequence: MAQKMLEDQDMLDQLLSGVHDSDLDFSESEEEEEEEESSSESESDEDSDMEVEPARQEAGPPEQCQQQPQQRAREQQPPPQQQQPQQREQGPPQQQQQQRTPKRGEESGDARPRARAPSGDAGPGPSGQARLPQQQQPQQPQQPPPKPPRQEVTVRAPGDRQQPQSQAAQPIPVIGGGCAPFQLRAPIAAAAATGWGGEQAPAQPLFQHVSPLNRRGDEDRRSGRDRRRREGRERDRESRSKGRNWYRPYPRGSSGARREGGGRDAGQGQGTRNPGPSQGGCEAGPSQAQAAQAARAPRQEQGERRQMLPQGQNLGPRPQQCPPQQCPPQPCPPFPLEALPILRAKFEPSCAVSYTNLVKSIQKIAMPPFLMRRREASPPCHFSKIPQATPGLVIPAAARTGEAKFEKFTDAFVQKVIDRGMSPQDCINKTVSLRKLDAKFDPLKTFTAKTVNFGQWLDVRKDSIINSGMSTQVVFLEELCAWAKLNLQHGCNLEERDLILHTAETVCSQLMYKLKPIMSCLEPNKPYASMAKQMAYLVCGAGRIQDAGMLLREVKVGSPLTMLVAFSLCVPVMITCRNRNPSLFNYCKSFLDMYQPGLLCALFNTMTSKLNTTCTEEECYASVRAAIGSVVNTRGLLFVPGI
What are the official names of this protein?
Immediate-early phosphoprotein 57.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL69 family.
Protein: KDUI_CERS5
Sequence: MTHIEIRHAMDPVSARQLDTAGLREAFHMADLFHEGEIRLVYTHYDRMIVGGAVPAGAPLVLDEVKPTGTASILDRREMGVVNIGGPGTVSAAGETWEMGRGDVLYLPMGAGPVTFAGQGRFYILSAPAHTAHPARLVTLADAKKVKMGAPETANERTINQFIHPEVMPSCQLVVGYTQFHGGSVWNTMPAHVHDRRMEVYLYFDLAQHARVFHFMGEPSETRHLVMKNEEAVVSPPWSIHCGCGTGAYTFIWAMAGDNVDYRDVEPVAMEDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: PURA_IDILO
Sequence: MSQNVVILGTQWGDEGKGKIVDLLTDKATMVVRYQGGHNAGHTLVIDGEKTVLHLIPSGILRKNVQCVIGNGVVLSPEALMEEMAMLEARHVPVADRLRISKACPLILPFHVALDQARERARGKEAIGTTGRGIGPAYEDKVARRGLRVGDLFDMKRFGEKLKELVDYHNFSLVEYYKADAIDFDTVLKQCEEFAEVLKPMVIDVPALLDKARKNGESIMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGAGFGPRYIDYVLGIVKAYTTRVGSGPFPTELDCEVGQHLGEKGHEFGATTGRKRRTGWIDAVAMRRAVQINSISGFCLTKLDVLDGLEELKICIGYQLSDGSVTEHPPLSAEDYEVVEPIYETMPGWQQSTVGITEHKELPPEALAYIARIEALTGVPVDIISTGPDRKETIVLRHPFGQ
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISX_GEOKA
Sequence: MKIERIRGGVSLRRTIESGTEEQRRAVLDIIANVRDRGDAALKEYTERFDGVKLDSLKVTEEEMKRAHAAMDAEMLEIIRQAAANIRDYHKRQKRESWWMTKEDGTILGQKVTPLDAVGLYVPGGTAAYPSSVLMNVIPAQVAGVKRIVITSPPNKDGTLPAGVLAAAYELGVTEIYKVGGAQAIAALAYGTETIRPVDKIFGPGNIYVALAKREVFGHVAIDMIAGPSEIVVLADETARPDEIAADLLSQAEHDVRASAILVTPSMKLALAVASEVERQLETLPRRDIAQAALENYGAIYVTETLEEAVDVVNELAPEHLEVMTAEPLALFGRLRHAGAMFFGRFSSEPVGDYFAGPNHVLPTNGTARFSSGLSVDEFVKKSSVIVYSETALKQHGDKIAAFARLEGLEAHARAIEVRLEKGE
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: SCX2_TITSE
Sequence: MKGFLLFISILMMIGTIVVGKEGYAMDHEGCKFSCFIRPAGFCDGYCKTHLKASSGYCAWPACYCYGVPDHIKVWDYATNKCGK
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.  This toxin acts on Nav1. 2/SCN2A, Nav1. 3/SCN3A, Nav1. 5/SCN5A, Nav1. 6/SCN8A and Nav1. 7/SCN9A voltage-gated sodium channels, with the highest affinity for Nav1. 3/SCN3A, followed by Nav1. 6/SCN8A and Nav1. 7/SCN9A which are affected almost equally.  Interestingly, shows a significant shift of the voltage dependence of activation for Nav1. 3/SCN3A that is characteristic of beta-toxins (PubMed:21549737).  In addition, in presence of LPS, this toxin inhibits the release of NO, IL-6 and TNF-alpha in J774. 1 cells (PubMed:21549737).  Further, in the absence of LPS, it stimulates the production of the anti-inflammatory cytokine IL-10 (PubMed:21549737, PubMed:23085190).  This toxin is active on mammals.
What are the official names of this protein?
Alpha-mammal toxin Ts2, P-Mice-beta* NaTx5.1, Tityustoxin II, Toxin II, TsTX-II, Tst2, Toxin T1-IV, TsTX III-8, TsTX-III.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HSLU_METRJ
Sequence: MTTFSPREIVSELDRFIVGQHDAKRAVAIALRNRWRRQQLTGPLREEVAPKNILMIGPTGCGKTEIARRLARLANAPFLKVEATKFTEVGYVGRDVEQIVRDLVEVAIGLTRQAKREGVKAKAEAAAENRILDALVGPTASQATRDSFRRKLRNSELDDKEVELELTSSAPAGMPMFEIPGVPGASMGAINIGDMLGKALGGQRGKPRRILVRDAYAPLMAEESDKLVDDEALVREAIREVENNGIVFLDEIDKICAREGRSSGDVSREGVQRDLLPLIEGTTVATKHGPVKTDHVLFIASGAFHVSKPADLLPELQGRLPIRVELQPLTVDDFKQILTATEASLLKQTVALMETEGVTLTFTDDAVDALARVAVEVNSSVENIGARRLQTVLERVIDEISFTATDRSGETVPIDAAYVRERVQDLASNADLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT24_YEAST
Sequence: MKVPLGLWKVSRGNLWSTQKRVLTMSRCLNSDAGNEAKTVREGPAFSADLYMHPEKWKGLPPQRILELYWERMARLGSEYKPNKDELNALLTTSEYSNVPVNDIKKLYHRGEQGAIDIKGGNVNRDNSLRPFMFDELPSQAQELVAQHREQRFYNRLAAYELPLLAQYRQEYKRPSPESHPVTYRYTSYVGEEHPNSRKVVLSVKTKELGLEEKSLHKFRILARSRYDHTTDIFKMSSDKFEHASQNARYLHDILQRLLAESKDLTEDDFSDVPLDTRHTIAKSLRKKKRDYEFPEHWKRPEDAPKKKFDIVDQLLSTL
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
37S ribosomal protein S24, mitochondrial, Mitochondrial ribosomal small subunit protein 24, Mitochondrial small ribosomal subunit protein mS35.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS35 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Protein: CYTC_HUMAN
Sequence: MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA
What is the function of this protein?
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
What are the official names of this protein?
Cystatin-C, Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HFLD_ACIAD
Sequence: MVDTPFQQPQSLNVRQNRALALAGVFQATQLTHMTAMTGQQSIGETGNFYFEQLIKASLNIRPALNTSTQTLDFFNQLGDIALGLKTLESSINQPFSTTPKSKIPKLPSAKLPMSYAMALLQLEKKVYSNPEYVAVIEKSQQKILKQLSFFDNNYMHPSIIANLAQAYVDTAGQINPRILVRGNAESFKDPNHTNRIRASLFTGLQLAHLWRQLGGSSWNMIFSKRKLLQDIQTLARLQYQMV
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SPED_XYLF2
Sequence: MVKPLPRLRLQGFNNLTKALSFNIYDVCYARTEEERQRYIDYIDERYDADRLTQILTDVAEIIGANILNIARQDYDPQGASVTILISEEPVIDKKQAGKELISDAVVTHMDKSHITVHTYPETHPQEGIATFRADIDVATCGVISPLKALNYLIESLESDIVIMDYRVRGFTRDVKGKKHFIDHKINSIQNFLSKSIKSRYEMFDVNVYQENIFHTKMHLKDFDLDQYLFEEKARNLSFKERMKIEALLKLEIEELFHGRNLAE
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: GSA_SHESW
Sequence: MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWGPMILGHNHPKIRAAVLAAVENGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLGQPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPTEISCIIIEPVAGNMNCIPPVPGFLQGLRDMCDEFGALLIIDEVMTGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMDALCEEGLYEALSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQEQITRFDQVTKCNIEHFRTFYHGMLDEGVYLAPSAYEAGFLSMAHGEEELRLTLEAADRVLASMKTES
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHPT1_XENLA
Sequence: MGLAEGLAARMAPHLYIQEPLSAQQLKKLEEHKYSASGRSLVEPPMQVYWNWLVEKVPLWLAPNTITMVGLLLNVLSTLILVCYCPTATEGAPFWTYLLCAIGLFVYQSLDAIDGKQARRTNSSSPLGEMFDHGCDSISIVFVNLGTIAAVRLGTLPGWMFYCCFVGMFMFYCAQWQTYVCGTLKFGIIDVTELQISVTVMFLMTAVCGPELWDYEIPFTGLPMKTIPLLGIIGGTVYSCSNYFRVILSGGVGKNGSTVAGTSVLSPGLHIGLVLLLALMIYKKSTTNLFLQNPCLYTLAFGFVSAKITIKLVIAHMTKSEISLQDTAFIGPGLLFFNQYFNSFIDEYIVLWIAMVISFADLLRYCISVCLQIATHLRISVFRISSNQAAEQVQTQKQKLTD
What is the function of this protein?
Catalyzes phosphatidylcholine biosynthesis from CDP-choline.  It thereby plays a central role in the formation and maintenance of vesicular membranes.
What are the official names of this protein?
Cholinephosphotransferase 1, Diacylglycerol cholinephosphotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: PACC1_XENLA
Sequence: MEAIRKELSRSYQELNDETDPIARDPEGAQEEEQEEAASAVVPDRDSDRSNTRVHFSRTCLKNVFSVLLIFVYLLLMGVAVFLVYQTITDFRDKLKHPVMSVSYKEVNVYDAPGIALYPGKARLLSCKHHLYDHIPPLIDPGQPGENTCITQNISYTDPYTNSTVKHALIVQGPRDVRRRELVFLQFHLNETKQDFSAIDYLLFSSYDAFLKSTNRVRFMQDCESSFSSWKFSGGFRTWVKMSLVKTKEEDGSQSVEFRQETSVVNFIDRRENPDKGDQLFFVVFEWKDPYIQEIQDIITANPWSMIALLCSVFLVLFKAADFAKLSVKWMIKVRRRHLKKRTRELNHIS
What is the function of this protein?
Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH.
What are the official names of this protein?
Proton-activated chloride channel, PAC, Transmembrane protein 206.
What is the protein family that this protein belongs to?
Belongs to the proton-activated chloride channel family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCSH_BART1
Sequence: MSKTYFTQDHEWLSVDGQMVTVGVTHYAQEQLGDLVFVDLPQSGTKLSKGEAAAVVESVKAASDVYSPLDGEVVEINEALTDNPELVNQKAETEGWLWKMTLQDETQLEELLDEDAYKALIG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: BIPA_ECO57
Sequence: MIEKLRNIAIIAHVDHGKTTLVDKLLQQSGTFDSRAETQERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGLDHEDMAEDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIGRIKRGKVKPNQQVTIIDSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIVAITGLGELNISDTVCDTQNVEALPALSVDEPTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTGKKLTNMRASGTDEAVVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRANRAPKDD
What is the function of this protein?
A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation.  Binds GTP and analogs.  Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
What are the official names of this protein?
50S ribosomal subunit assembly factor BipA, GTP-binding protein BipA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Binds to ribosomes.
Protein: SYP_GEODF
Sequence: MRYSQYFIPTVKETPSDAEVISHQLMLRGGMIRKLAAGVYNYLPLGLRSIRKVENIVREEMNRAGAIELLMPTVQPAELWQESGRWEQYGKELLRFRDRKDTEFCLGPTHEEVITDLVRREVKSYRQLPINLYQIQGKFRDEIRPRFGLMRGREFIMKDAYSFDVDEKAADISYDKMYQAYRRIFERCGLKFRAVEADTGSIGGSWSHEFMVLAESGEDAIVSCTACDYAANVEKAEARQSAVTEHADPRDMEKVSTPEKKSIEEVAAFLAIHESSLVKTLVLLADNEPVVALLRGDHELNEIKLKNILGCDTLEMAGEEVVVKVTGAPTGFAGPVGLKAKIIADLAVQGMKNFVTGANAKDLHLKNVNLGRDFNVTTFADIRNVVLGDPCPRCESGTLEMWRGIEVGHVFKLGTKYSKAMKATYLDADGKEQIIFMGCYGIGIGRTVAACIEQNHDENGIIFPLPIAPFHCIISALNMKEDVVREASEAIYGQLAAAGIEVLLDDRDERPGFKFKDADLIGIPMRIVVGSKNLADGKVELKCRRSGEVELLSIADAVEKVKAAVNAALK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSF3_XENLA
Sequence: MWEPYMPVEPGLGREENFLSLEDLLMSQEKLPCCIESGFPRLGFLDKGGDSDSIPEGSKMELPLWLAKGLYDNKRRVLSVELPKIYREGWRTVFSADANVVDLHKMGPHYYGFGSQLLNFDSPENPEIAKTILQTFVGRFRRIMDSSQNAYNEDTSGLVARLDELERSLFRAGQRGLNAFQSWERGKAAQITASNLVQNYKKRKFNEADA
What is the function of this protein?
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks.  GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
What are the official names of this protein?
DNA replication complex GINS protein PSF3, GINS complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the GINS3/PSF3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with chromatin.