PharMolix/UniProtQA huggingface dataset:
Protein: CPXL_PSESP
Sequence: MDARATIPEHIARTVILPQGYADDEVIYPAFKWLRDEQPLAMAHIEGYDPMWIATKHADVMQIGKQPGLFSNAEGSEILYDQNNEAFMRSISGGCPHVIDSLTSMDPPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALYYPLHVVMTALGVPEDDEPLMLKLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIATFYDYFNGFTVDRRSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPEQLALAKSDPALIPRLVDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRFPNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATNFVGGPKNVPIRFTKA
What is the function of this protein?
Catalyzes the hydroxylation of alpha-terpineol.
What are the official names of this protein?
Cytochrome P450-terp, Cytochrome P450terp, Cytochrome P450 108.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_ALKOO
Sequence: MPLKGKHLIDPDQLTFNEIHEIINLGLDMEQNPAKYSKVCEGKILGTMFFEPSTRTRLSFESAMLRMGGTVLGFSDVTTSSVTKGESVADTIRVLDDYADILVMRHPVAGTPREASQYSTVPVINGGDGGHQHPTQTLTDLITIQKYHGEIRGLKVAFCGDLLFGRTVHSLLKTLSRFPDMEFILISPPELPIPEDLKTEVIEKYNVKITETDSLEKHMAEIDILYMTRIQKERFLNQEDYEKLKDSYILTNSLLENAKQDLIILHPLPRVNEIHTEVDRDPRAKYFEQAKMGVYVRMALMALLLGNIEIAAPTLTLKVKNGTIMTKFIAS
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: DNAA_SALSV
Sequence: MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNTFCGADAPQLRFEVGTKPVTQTLKTPVHNVVAPAQTTTAQPQRVAPAARSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKIADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESXC_MYCTO
Sequence: MSDQITYNPGAVSDFASDVGSRAGQLHMIYEDTASKTNALQEFFAGHGAQGFFDAQAQMLSGLQGLIETVGQHGTTTGHVLDNAIGTDQAIAGLF
What are the official names of this protein?
ESAT-6-like protein EsxC.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. ESAT-6 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX-2 / type VII secretion system (T7SS).
Protein: MNMA_EHRRW
Sequence: MLDDFKIDLLVKNKPPTSTTAVVAMSGGVDSSVAAALLHKLGYKVIGITLQLYNNNNNSNTKGACCGSLDTQDAKQVASSMGFPHYTLNYEKVFREEVIEDFIDTYTQGKTPIPCIKCNQVIKFRDLLNATKSLGADVLVTGHYIRKIEQDDDIYVYSSKDTKKDQSYFLFATTVEQLRLLRFPLGNFHKEDIRKLAKYFNLQVANKPDSQNICFVTDTYKKTIAELRPHTIKKGNIIDINGNILSQHNGIVNFTIGQRKGIGISSKAPLYVIKLNPDTNEVTVGPKSALLQNKLYIREINWLAKEKIPHNGLNVKVKLRSSHSGSPATIFPNNNNTATILLQDSYCTVTPGQACVIYDHDRMLGGGWIC
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASPX_VULVU
Sequence: MKEVYLVGYARGASGQSDEPPGSMDHQASVQRLSGEYFSLGNPSDGEALYETAAGENTLSEHTSGEHTSVEHASAEHSSTEHTSGEHASGEHTSGERATGEHTSSEHATSEHTSGEQPSGEQPSGEKSSGEQPSGEKSSGEQPSGEKSLGEQPSGEQSSGEKSSAEQTSGEQAVAEKPSGEHAVAEKPSGEQAVAERPSGEQAVAEKPLGEQAVAERPSGEQASIEKASSEQASAEQASAEQASSEQASGEKPLGEQPSGIPPSSTFSGPILNCHTCSYMNDQGKCLRGEGVCSTQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIICCRNQSFCNKI
What are the official names of this protein?
Sperm acrosomal protein FSA-ACR.1.
What is the protein family that this protein belongs to?
To acrosomal proteins SP-10.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Intracellular acrosomal compartment of sperm.
Protein: RL15_GLUDA
Sequence: MNLNELRDNAGSRYRKKRLGRGIGSGKGKTSGKGVKGQKAREGVSLNGFEGGQLPLYRRLPKRGFKNIFRKEYAPVNLGALDKAIADGKIDAGTVVTEDVLRTAGLVGSGKFAGVRLLAKGELARAVTIEVSGASATAVAAVEKAGGSVRTKAARDEAQAPA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: VPS38_ARATH
Sequence: MERVSERSLSENLRRSDREDGKIIEWEEFDHELTRLWSLSSAMKLATERKQILQPKLESLIQVSTESLRRTNELEEMRQRLEARKLLVDKTSVACKVTEQDVKKKEENLSTEVRSLLVGGTTLSIAKSKLQESNCQLEGESGYAHLKIVTNKLRKRQQFMVSQVSFIYPLKIEAGPSQDQELESFPGGSRLGTKPLSQGSVRILGLPFSMAPFTKMSFFTDKKEVQKSATALGYVAHAVSLIAPYLRVPIRYPLCLGGSKTYIRDYAPYIEPSPSDMSPITTLSQNINFVEFPLFLDGQDTTRAAYAVFLLNKNIEQLLNFVGENSLGPRQVLANLKELIRIIQSPDYIDYL
What is the function of this protein?
Dispensable for autophagy but essential for efficient targeting and degradation of biosynthetic and endocytic cargo to the vacuole (PubMed:29184027).  Required for seedling development and plant growth as well as for seed storage proteins (SSPs) vacuolar trafficking (PubMed:29184027).  Controls multiple aspects of development by affecting late endosome morphology and by regulating vacuolar and endocytic cargos (e. g PIN1 and PIN2) trafficking and distributions (e. g.  polarity), thus influencing auxin transport orientation (PubMed:29897620, PubMed:29184027).
What are the official names of this protein?
Vacuolar protein sorting 38, Protein UNFLATTENED AND SMALL LEAVES 1.
Protein: TIG_STAAW
Sequence: MTATWEKKEGNEGLLTVTVPAEKVNKALDQAFKKVVKQINVPGFRKGKVPRPIFEQRFGVEALYQDAIDILLPDAYGEAIDETDIKPVAQPEVSVTQIEKGKDFIFEATVTVEPEVKLGDYKGLEIEKQETELSDDELQEAIDHSLGHLAEMVVKEDGVVENGDTVNIDFSGSVDGEEFEGGQAEGYDLEIGSGSFIPGFEEQLEGMKVDEEKDVVVTFPEEYHAEELAGKEATFKTKVNEIKFKEVPELTDEIANELDAEANTVDEYKENLRKRLAEQKATDAENVEKEEAITKATDNTTIDIPEAMVNTELDRMVSEFAQRIQQQGLDLQTYFQISGQDETQLREQMKDDAEQRVKTNLTLTAIAEAEKIEATDEDIDKELEKMSKQFNISVEDIKNTLGNTDIIKNDVRIQKVIDLLRDNAKFVEGTKED
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: FMO3_RAT
Sequence: MKRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHTEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHNSKLQEYITSFATEKNLLKYIQFETLVTRINKCPDFSTTGKWEVTTEKNSKKETAVFDAVMICSGHHVYPHLPKDSFPGLNRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGSWVMSRVWNDGYPWDMVVITRFQTFLKNNLPTAISDWWYMKQMNARFKHENYGLMPLNGTLRKEPVFNDELPARILCGTVSIKPNVKEFTETSAVFEDGTVFEGIDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTTDLQARWAAQVIRGTCILPSVNDMMDDIDEKMGKKLKWFGNSTTIQTDYIVYMDELASFIGAKPNILWLFLKDPRLAIEVFFGPCSPYQFRLVGPGKWSGARNAILTQWDRSLKPMKTRVVGGIQKPCLYSHFLRLLAVPVLIALFLVLI
What is the function of this protein?
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:3739217, PubMed:7736906).  Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite.  TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.  By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
What are the official names of this protein?
Flavin-containing monooxygenase 3, Dimethylaniline monooxygenase [N-oxide-forming] 3, Dimethylaniline oxidase 3, Hepatic flavin-containing monooxygenase 3, FMO 3, Trimethylamine monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: PIGU_MOUSE
Sequence: MAAPLALVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLALLDLGVSPYSGAVFHETPLIIYLFHFLIDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSVFLSAVFLALATYQSLYPVTLFAPGLLYLLQRQYIPVKVKSKAFWIFSWEYAMMYTGSLVVIVCLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTVPLAIKLKEHPIFFMFIQIAIISIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITLTFNVGQILLISDYFYAFLRREYYLTHGLYLTAKDGTEAMLVLK
What is the function of this protein?
Component of the GPI transamidase complex.  May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI (By similarity).
What are the official names of this protein?
Phosphatidylinositol glycan anchor biosynthesis class U protein, Cell division cycle protein 91-like 1, Protein CDC91-like 1, GPI transamidase component PIG-U.
What is the protein family that this protein belongs to?
Belongs to the PIGU family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GUAA_NOSS1
Sequence: MNTAVTLLTEQAPQPIEEFGQLERQIIIILDFGSQYSELIARRIRETQVYSEVLSYRTPAEHLRQLNPKGIILSGGPSSVYSDRAPHCDPEIWNLGVPILGVCYGMQLMVNQLGGEVAKADRGEYGKASLHIDDPTDLLTNVEDGTTMWMSHGDSVTKMPPGFEVLAHTDNTPCAAVADHEKKLYGVQFHPEVVHSVGGLALIRNFVYHICECEPTWTTAAFVEEAIREVRAKVGDKRVLLALSGGVDSSTLAFLMHKAIGDQLTCVFIDQGFMRKYEPERLVKLFQEQFHIPVEYVNARDRFLDIMSGVTDPEEKRRRIGHEFIQVFEETSKNLGPFDYLAQGTLYPDVIESADTNVDPQTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRKVGRSVGLPEEIVQRQPFPGPGLAIRILGEVTADRLNILRDADLIVRQEINQRGLYNEYWQAFAVLLPIRSVGVMGDQRTYAYPIVLRIVKSEDGMTADWARVPYDVLEAISNRIVNEVKGVNRVVFDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RL21_STAAB
Sequence: MFAIIETGGKQIKVEEGQEIFVEKLDVNEGDTFTFDKVLFVGGDSVKVGAPTVEGATVTATVNKQGRGKKITVFTYKRRKNSKRKKGHRQPYTKLTIDKINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RR18_ANGEV
Sequence: MNRTKRSSRRRLPPIRSGEIIDYKNISLLRRFMSEQGKILSRRINRLTSKQQRLMTVAIKRARILALSPFLNNES
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RPOB_ALISL
Sequence: MVYSYTEKKRIRKDFGKRPQVLDIPYLLSIQLDSFTKFIEQDPEGQYGLEAAFRSVFPIQSYNGNSKLEYVSYNLREPEFDVKECQIRGVTYSAPLRVKLRLVVYDKDAPAGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARVIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIILRALRKTTEEILDLFFDKVVFEVKDQTLMMELLPERLRGETATFDIESNGKVYVEAGRRITARHIRQLTKDEVNNIEVPVDYIVGKVASHDYVNEDTGEIIIAANQEFSLEDLANLSQAGHKKIEVLFTNDLDHGAYISDTLRADSTVDRLSALVEVYRMMRPGEPPTKEAAESLFESLFFSEDRYDLSTVGRMKFNSSIGRDNGEGAGILDETDIIEVMRKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVRERLSLGDLDAIMPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRLCPIETPEGPNIGLINSLSAYARCNEYGFLETPYRRVVDNIVTEDVDYLSAIEEGTFVIAQANAVLTEEGTFADELIIARQKGESGLHPREHIQYMDVATNQVVSVAASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGIERCVAIDSGVTAVAKRGGMVQSVDASRIVIKVNEEELVPGEAGIDIYNLTKYTRSNQNTCINQRPTVLPGEPVTRGDVLADGPSTDLGELALGQNMRIAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTIIDVQVFTRDGVEKDKRALEIEQMQLKEAKKDITEEFQILEGGLLARVRTLLTLAGTSEVKLDAMDRKQWLEITLDDESQQNQLEQLAEQYDELKAEFDKKFETKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPVEDMPYDEKGQPVDIVLNPLGVPSRMNIGQILEVHMGLAAKGVGDKLNQMLKEQQELHKFRNFLQKVYDLGETRQEVDIAALSDDEVRTLVKNLRGGLPIATPIFDGAPESSIKELLKLVDLPESGQLKLFDGRTGDAFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEPGMPESFNVLLKEIRSLGINIELEDEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: GLN1B_ECOL6
Sequence: MSAEHVLTMLNEHEVKFVDLRFTDTKGKEQHVTIPAHQVNAEFFEEGKMFDGSSIGGWKGINESDMVLMPDASTAVIDPFFADSTLIIRCDILEPGTLQGYDRDPRSIAKRAEDYLRSTGIADTVLFGPEPEFFLFDDIRFGSSISGSHVAIDDIEGAWNSSTQYEGGNKGHRPAVKGGYFPVPPVDSAQDIRSEMCLVMEQMGLVVEAHHHEVATAGQNEVATRFNTMTKKADEIQIYKYVVHNVAHRFGKTATFMPKPMFGDNGSGMHCHMSLSKNGVNLFAGDKYAGLSEQALYYIGGVIKHAKAINALANPTTNSYKRLVPGYEAPVMLAYSARNRSASIRIPVVSSPKARRIEVRFPDPAANPYLCFAALLMAGLDGIKNKIHPGEAMDKNLYDLPPEEAKEIPQVAGSLEEALNELDLDREFLKAGGVFTDEAIDAYIALRREEDDRVRMTPHPVEFELYYSV
What is the function of this protein?
Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I beta, GSI beta.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_COXB1
Sequence: MEAHKPVLFDEVMEGLAIRPDGIYVDGTFGRGGHSFGILQRLGPNGRLMAMDKDPDAVAVANKALFEDARFSIVHETFANLQKAVRDRGWEGKVNGILLDIGVSSPQLEDAKRGFSFSKDGPLDMRMNPKQSMDAASWINQAAMEDIRRVLWNYGEERFAKRIAQAIVNAREEKPITRTQELSDIVIKAYPQREIKKHPATRTFQAIRIFINRELDELRECLPQCLETLAVGGRLCVISFHSLEDRLVKRFIQKESRDHLPREIPILAKDIKHRLKPLGSLIRPTEAEIKKNPRARSARLRIVEKLS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRCA_YERPB
Sequence: MITGIQITKANNEALLNSFWLLDDEKAELRCVCAKSGYAEDQIVPTSELGEIEYREVPLEVQPTVRVEGGQHLNVNVLSRDTLEDAVKNPEKYPQLTIRVSGYAVRFNSLTPEQQRDVITRTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: SYGA_VIBPA
Sequence: MQKYDIKTFQGMILALQDYWAQNGCTIVQPLDMEVGAGTSHPMTCLRALGPEPMSTAYVQPSRRPTDGRYGENPNRLQHYYQFQVALKPSPDNIQELYLGSLEVLGIDPLVHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGIERLAMYIQEVDSVYDLTWNIAPDGSKVTYGDIFHQNEVEQSTYNFEHADVDFLFSFFDQCEKESKELLELEKPLPLPAYERILKAAHAFNLLDARKAISVTERQRYILRIRNLTKAVAEAYYASREALGFPMCKKEQA
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL1B_PUSHI
Sequence: MATVPEPTSEMMSYYYSDNENDLFFEADGPRKMKCCFQDLNNSSLKDEGIQLHISHQLQNKSLRHFVSVVVALEKLKKISLPCSQPLQDDDLKNVFCCIFEEEPIVCEVYDDDAFVCDAPLQSLDCKFRDKNQKSLVLYNSYELRALHLNGSSVNQQAVFRMSFLQGDENSNKIPVALCIKEKNLYLSCVMKDGKPTLQLEMLDPRVYPKKKMEKRFVFNKTEVKKILEFESSQFPNWYISTSKAEAMPVFLGNTKGGQDITDFTMEFSS
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: SEC11_YEAS7
Sequence: MNLRFELQKLLNVCFLFASAYMFWQGLAIATNSASPIVVVLSGSMEPAFQRGDILFLWNRNTFNQVGDVVVYEVEGKQIPIVHRVLRQHNNHADKQFLLTKGDNNAGNDISLYANKKIYLNKSKEIVGTVKGYFPQLGYITIWISENKYAKFALLGMLGLSALLGGE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Secretory protein 11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: YFLP_BACSU
Sequence: MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGWDVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDLLGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFGNDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNGDITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKVTSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN
What are the official names of this protein?
UPF0065 protein YflP.
What is the protein family that this protein belongs to?
Belongs to the UPF0065 (bug) family.
Protein: ATPA_PSYWF
Sequence: MQQLNPAEISQLIKQRIQDLDTSATAKNEGTIVKVSDGIVQIHGLEDAMYGEMIEFEGDVYGMALNLEQDSVGAVVLGDYLGLQEGQKAYCTGRILEVPVGPELLGRVVDALGNPIDGKGPINAKLTDKVEKIAPGVIARQSVDEPVMTGYKAVDTMIPIGRGQRELIIGDRQTGKTAMAIDAIIAQKNSGIKCVYVAIGQKRSTIANVVRKLEETGALAYTTVVVASASEPAALQYIAPYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVNAAYVEEFTNGEVKGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLFNSGIRPAVNAGISVSRVGGAAQTKIIKKLSGGIRTALAQYRELAAFAQFASDLDDATKQQLDHGERVTELMKQKQYQPMSIAEQAAVIFASNEGYLSAIPVEKIGAWEEAYLRYMYDEQADLMQEINDTANYNDDIAGRLKSSVETFLQNHTF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UN41_CLOPA
Sequence: MIYSTEVSNMAGV
What are the official names of this protein?
Unknown protein CP 41 from 2D-PAGE.
Protein: G6PI2_NEIMB
Sequence: MNAFTRAWYALERHYQDTRHVLLRDRFACEPDRFERMHERLDGMLFDYSKNRLGEDTLQLLCNLADAADLEGKMRALRTGAKVNGSEGRAALHTALRLPDGADAVYVDGRDVLPEIRRELNRALKFAHSLDDGSYQGITGKRITDFVHIGIGGSDLGPAMCVQALEPFRRHITVHFAANADPACLDAVLCRLNPETTVFCVASKSFKTPETLLNAQAVKAWYRGAGFSESETACHFCAVSADTAAAAAFGIAAERVFAMYDWVGGRYSVWSPVGLPVMVAVGGARFRELLAGAHAMDRHFFSTPTRHNIPVLMALIAVWYNNFQHADGQTAVPYSHNLRLLPAWLNQLDMESLGKSRASDGSPAVCKTGGIVFGGEGVNCQHAYFQLLHQGTRLIPCDFIVPMTAQGREDGRSRFTVANAFAQAEALMKGKTLDEARAELADLPEAERERLAPHKEFPGNRPSNSILIDRLTPYNLGMLMAAYEHKTFVQGAIWNVNPFDQWGVEYGKQLAKTIIGELEGGTSVHDASTEGLMAFYRECRLKGGGAA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase 2, GPI 2, Phosphoglucose isomerase 2, PGI 2, Phosphohexose isomerase 2, PHI 2.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y835_NEIMF
Sequence: MFFVLSPAKNLNEKDPAPVSEFTQPDLLAESDILMQQLRELAPQQIAELMHVSDKIALLNAQRNAEWNTPFTPENAKQAVFMFNGDVYEGMDANTLNTDQIQYLQGRVRLLSGLYGLLRPLDLIQPYRLEMGTAFANLRGKNLYEFWGDIITNLLNDTLAQAGSNTLVNLASQEYFKSVNTKTLRARLITPIFKDEKNGKYKIISFYAKRARGLMVRYAAEHNITDPEMLKNFNYEGYAFNDAASNESEWVFMRSEQIK
What are the official names of this protein?
UPF0246 protein NMC0835.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: RIMP_STAAT
Sequence: MSKITEQVEVIVKPIMEDLNFELVDVEYVKEGRDHFLRISIDKEGGVDLNDCTLASEKISEAMDANDPIPEMYYLDVASPGAERPIKKEQDFQNAITKPVFVSLYVPIEGEKEWLGILQEVNNETIVVQVKIKARTKDIEIPRDKIAKARHAVMI
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN430_HUMAN
Sequence: MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQGKEPWNMKRHAMVDQPPVTYSHFAQDLWPEQGIKDSFQEVILRRYGKCGHEDLQLRTGCKSVDECNLHKECYDELNQCLTTTQSEIFQYDKYVNVFYKFSNPNIQKIRHTGKKPFKCKKCDKSFCMLLHLTQHKRIHIRENSYQCEECGKVFNWFSTLTRHRRIHTGEKPYKCEQCGKAFKQSSTLTTHKIIHTGEKPYRCEECGKTFNRSSHLTTHKRIHTGEKPYRCEECGRAFNRSSHLTTHKIIHTGEKPYKCEECGKAFNQSSTLTTHKIIHAGEKPYKCEECGKAFYRFSYLTKHKIIHTGEKFYKCEECGKGFNWSSTLTKHKRIHTGEKPYKCEQCGKAFNESSNLTAHKIIHTGEKPYKCEECGKAFNRSPKLTAHKVIHSGEKPYKCEECGKAFNQFSNLTKHKITHIGDTSYKYLECDKAFSQSSTLTKHKVIHTGEKPYNCEEYGKAFNQSSNLIEQSNSYWRETLQM
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 430.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH10_ARTS2
Sequence: MSVSIKPLEDRIVVRPLEAEQTTASGLVIPDSAQEKPQEGEVVAVGPGRFEDGNRVPVDVAVGDVVIYSKYGGTEVKTGGTEYLVLSARDVLAIVVK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.