PharMolix/UniProtQA huggingface dataset:
Protein: TREM1_PONAB
Sequence: MRKTRLWGLLWMFFVSELLAATKLTEEKYELKEGQTLDVKCDYMLEKFASSRKAWQIIRDGEMPQTLACTERPSHPVQVGRIILEDYHDHGLLHVRMTNLQVEDSGLYQCVIYQPPKEPHVLFDRIRLVVTKGSSGTPGSSENSTPNVYKTPPTTTKALRPLYTSPTTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIAILVAGGFLSKSLVFSVLFAVTLRSFVP
What is the function of this protein?
Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses.  Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12.  In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma.  This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections.  By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.
What are the official names of this protein?
Triggering receptor expressed on myeloid cells 1, TREM-1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Recruited to lipid rafts when activated.
Protein: YGIM_ECOL6
Sequence: MPKLRLIGLTLLALSATAVSHAEETRYVSDELNTWVRSGPGDHYRLVGTVNAGEEVTLLQTDANTNYAQVKDSSGRTAWIPLKQLSTEPSLRSRVPDLENQVKTLTDKLTNIDNTWNQRTAEMQQKVAQSDSVINGLKEENQKLKNELIVAQKKVDAASVQLDDKQRTIIMQWFMYGGGVLGLGLLLGLVLPHLIPSRKRKDRWMN
What are the official names of this protein?
Uncharacterized protein YgiM.
What is the protein family that this protein belongs to?
To H.influenzae HI_1605.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PURL_THEKO
Sequence: MFPHEEKLIRERLGREPNEVEKAMLEVMWSEHASYKSSRPFLKLLPTENEHVVLGPGEDAGIVKFDDETWIAVGIESHNHPSAVEPYGGAATGVGGIVRDILCMGARPIALLDPIRFGPLEKERNRYLLQGVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVACVGIMRPEHFVHSYVEEAGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTGKVRALKDLGGGGLTCASSEMAGKKGFGAVIYADRVPLREPNMTPTEVMISESQERMLFAVREEDVEEIGKIFEKYGLEWTVVGEIIKEPRYIVYWKGEKVADLPIDLLTEVPTIEWETRPYSLERDVETPKISFSDAFELVWSSPNVLNKRWVWEQYDHEVQGRTVVKPGRDAAVLKINERYGLAFVADGNPNHSHLNPYHGAMGAVAEVVRNLVSVGAEPLALVDNLNFASPERPEVYWSFAETVRGLADAARAFGLAYVSGNVSFYNEVVDRPIKPTPVVAGLGKVELEKIPGFGLEEGLLIGVVGSTKRELGGSELYVRLGLKGGIAPRVNLEEEKANAEGILEAIRRGLLKAVHDVSKGGIAVALAEMAVLGNTGFTADLSKVPAETSNPLEVAFSESHGRYIVVFPEERLEELKALFRHFAVIGRAGGSGAVFLWNGDELLRKPITKLREVHESFPKLLGEEE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_FRATF
Sequence: MRHRKQGRKFGRTSSHRKAMFKNMSASLINHELIKTTLPKAKELRTIVEPLVTLAKREHKLRQELDTNSNEFKAQSVALRRQAFDFLRNKAAVTKLFEEFGARYAERAGGYTRILKCGYRFGDKAPMAFIELVDRPQVEEAADEE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: ELF5_MOUSE
Sequence: MLDSVTHSTFLPNASFCDPLMPWTDLFSNEDYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAGICGEYLYFILQNIRSQGYSFFNDAEETKTGIKDYADSSCLKTSGIKSQDCHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEEKL
What is the function of this protein?
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity).  Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT].  Transcriptionally activates the TK promoter.
What are the official names of this protein?
ETS-related transcription factor Elf-5, E74-like factor 5.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HUTU_SHEB8
Sequence: MDKRHDPSRRIIAPHGTQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWDCYDKIIEVLQRLEDDETLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNELDKLGLAMYGQMTAGSWIYIGTQGIVQGTYETFVSVAKQHFEGISKGKWILTGGLGGMGGAQTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMIEAANQAGKPVSVGLLANAADVFAELVKRGVTPDVVTDQTSAHDPLNGYLPQGWTMAEAAAMRKTDEAGVVKAAKASMAVQVQAMLDLQTAGAATLDYGNNIRQMAFEMGVENAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPARICWVGLKDRARLALAFNEMVKNGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRVGRVLWNDPATGVMRHADAGYEIAKNCAKEQGLDLPMQE
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_MOOTA
Sequence: MATIGFIGVGLAIGLAALGSGLGQGIASRGALEGMARQPEASGDIRTTLLLALAFMEALTLFSFVIAILMWTKL
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FETC_ASPFU
Sequence: MAVGFLLLTAFVVNILTTSAATLHYDWNITWVTANPDGQFERPVIGINGQWPPPVLSFTRGDRIIAKVHNALGNETTSVHWHGFFQNGTNHMDGPPSVTQCDIAPGSTFVYNFTVEQSGTYWYHSHTKGQYPDGLRQALVVTDPKNPYIGQYDEERVISLSDWYHDQMPTLLKSFISISNPTGAEPVPKAALMNDTQNLTVAVEPGKTYLFHLVNVGAFASQYFWIEDHTMKIVEVDGVWTHASEANMIYIASAQRYSVLVTMKNETSQNYAMVGSMDTDLFDTLPESLNYNVTGWLMYNDQADKPTPALVSAFEPYDDFNLVPVDGMALHKEADYTVTLDVTMDNLGDGANYAFFNGITYVMPKVPTLYSVLTTGSAATDPAVYGYNTHPIVLKRGDIVDIVLNNDDAGKHPFHLHGHTFQVIARSEENAGHYDPSNHTTFPSIPMRRDTVIVRPQGNFVLRFQADNPGVWLFHCHIEWHMDSGLAATFIEAPLDLQKTLKIPEDHYQVCEASGTLTAGNAAGNTKDLFDLTGQNVSPAPLPAGFTAKGIVALVFSCVAAILGLLSIAWYGMAPITAPRAGSTPSNDSDEN
What is the function of this protein?
Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism (PubMed:15504822).  Required to oxidize Fe(2+) and release it from the transporter (By similarity).
What are the official names of this protein?
Iron transport multicopper oxidase fetC, Cell surface ferroxidase fetC.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein; Extracellular side.
Protein: KDGD_DELAS
Sequence: MTPQDLKDVMSSGLLSFPVTDFDSNGNFNAKGYAARLEWLAPYGASALFAAGGTGEYFSLYGEEYGQIIKTAVDTCRGKVPIIAGAGGPTRTAIAHAQEAERLGAHGVLLLPHYLTEAGQEGLIAHVEQVCKSVKFGVIVYNRDRTRFTPESLAILAERCPNLVGFKDGMGNIETMSAIFMKMGDRFAYLGGLPTAEVYAAAYKALGTPVYSSAVFNFIPKTAMAFYEAVRTDDMATQHKLLKEFFMPYLKIRNRVEGYGVSIIKAGAKLVGHDAGPVRAPLTDLKPSELEELKALIDKLGPQ
What are the official names of this protein?
Probable 5-dehydro-4-deoxyglucarate dehydratase, 5-keto-4-deoxy-glucarate dehydratase, KDGDH.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
Protein: RF1_MESH7
Sequence: MEKKMFNSLMKIHQKYQDLKQLLETDQILNDQKQYLQIAKEIASITEIIEVFQKFLDDQKVLEDAKTILIQEDDPELIQLAKVEIATMSKNIEEYEKKLLILMLPKDKNDEKDVIVEIRGAAGGDEANIFVGDLFKMYHKWADSQKAKVKVLSSSLALAGGFSQIIFQISGQKIYSKLKFESGVHRVQRVPATETMGRIHTSTATVTVMPKIDEKIEIEINPSDLKIDTYRSSGAGGQSVNTTDSAVRITHIPTGIVVTSQDERSQIGNKEIAMGILKSKIYNLELQKQQQKQSDFRKLAGSGARSEKIRTYNYPQDRLTDHRINFSTSLKPIIQGSLNPIIEALLAQEKTELILQNYANK
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_GEODF
Sequence: MNKEGKHQLVTEVHDKLQRAKAVFLADFRGMNVGQATELRNELRKAAVEFKVVKNTLLELASKGTDKEALNPYFAGPTAVAITYDDPVAAAKVLSRFAKETTNPFTLKAGVLSGKAISPADIQALADLPSREVLIAKMLGSMQAPATNFVGVLAAVPGSFVRALNAIRIQKEGN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RBL_NOTSU
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVRAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEGLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAIDKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHAGTVVGKLEGERGITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGGDLAREGNEIIREASKWSPELAAACEVWKEIKFEFQAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CSA2A_SACS2
Sequence: MQLEVNNMWISFSVRYLVNVEDLNNVESAGNYVRHRRAPLVFKDKDSYTVTYVPAVSGEMIAHGYQMNLVELALQRNLPVDSLAKQGILIKRGSDDKVHEGTKCTDEKGSDYELCVINEDIVEDVAGFMNPNKLVKRTSNVAFSYMVPAIDAVKASTISSQFHVRYANKELMDKYKNENIQSLYNIETASASYVLTGYLNVNSVGKTQNYPVKEVDKKKDREKAALDALMLTLTQFLFGAKLTRFKPIVEIEALFVSASEKPFNLPPVTGDIKKYIDLVNSTTDSFAKILNIKRPVVKYYLKEEKGNVNTPIDAFTVM
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
What are the official names of this protein?
CRISPR-associated protein Cas7/Csa2 1, CRISPR-associated aCascade subunit Cas7/Csa2, subtype I-A/Apern 1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas7/Cst2/DevR family. Subtype I-a/Apern subfamily.
Protein: OSGEP_DICDI
Sequence: MVYIMGFEGSANKLGIGIVKDDGTILSNIRHTFITPPGEGFLPKDTAKHHRSFILSLVEKSLEESKLKPSDIDCLAYTKGPGMGPPLRSVAVTVRMLSQLWDRPIVAVNHCIAHIEMGRLITGAVDPTILYVSGGNTQVISYSLKKYRIFGETIDIAVGNCLDRFARVIQIPNDPSPGYNIEQLAKKGKNLIELPYITKGMDVSFSGILSSIEGMVKNKQNKTQHSVEDLCYSLQEHLFSMLVETAERALAHCGQNEVLAVGGVGCNQRLQEMIQQMISQRNGKSFAIDERYCIDNGAMIAWAGYLIFKNGTTTPLSQTTTTQRFRTDQVDVTWRD
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  Osgep likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
What are the official names of this protein?
Probable tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep, tRNA threonylcarbamoyladenosine biosynthesis protein osgep.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CLPX_SALA4
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRTHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVIANRVETGSGIGFGATVKAKSDKASEGELLSQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIARKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIAGQSKPLLIYGKPEAQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: CLPB2_CHLTE
Sequence: MHFDPNKFTVKAQEALQAASMLASSKQNQQIEPEHLLSVMLGDHDNIACQIARKLETPVDTLLSVVDREIDRIPKVTGASATGQYISSDLGKVFDTALKEAEQLKDEYISSEHLFIAMSEAGVKVSKLLKDAGIDRNAILKVLTSFRGSQRVTSQNAEESYQSLKKYSRNLNDLVIKGKLDPVIGRDDEIRRVLQILSRRTKNNPVLIGEPGVGKTAIVEGIAQRIVGGDVPENLKSKQIAALDIAALVAGTKFRGEFEERLKALVKEVQASDGEVILFIDELHLLVGAGSAEGSMDAANILKPALARGELRCIGATTLDEYRKHIEKDAALERRFQTVIVDQPSVEDTVSILRGLKEKYEIHHGVRIKDAALVAAAELSNRYIADRFLPDKAIDLIDEACSRLRLEIDSEPEELDRINRELRRLEIEREALKRELEATGSV
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Probable chaperone protein ClpB 2.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GFAP_HUMAN
Sequence: MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
What is the function of this protein?
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
What are the official names of this protein?
Glial fibrillary acidic protein, GFAP.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with intermediate filaments.
Protein: EPHA6_MOUSE
Sequence: MGGCEVREFLLQFGFFLPLLTAWTGDCSHVSNQVVLLDTTTVMGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLYYIESDESHGTKFKPSQYIKIDTIAADESFTQMDLGDRILKLNTEIREVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSSTYVEATSVCHCEKGYFRAEKDPPSMACTRPPSAPRNVAFNINETALILEWSPPSDTGGRKDLTYSVICKKCGLDTTQCEDCGGGLRFIPRHTGLINNSVVVLDFVSHVNYTFEIEAMNGVSELSISPKPFTAITVTTDHDAPSLIGMMRKDWASQNSLALSWQAPAFSNGAILDYEIKYYEKEHEQLTYSSTRSKAPSVIVTGLKPATTYIFHIRVRTATGYSGYSQKFEFETGDETSDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRTHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNGIQAPHPVTAGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQKERNHRPKFTDIVSFLDKLIRNPSALHTLVEDILVMPESPGDVPEYPLFVTVGDWLDSIKMGQYKSNFMAAGFTTFDLISRMSIDDIRRIGVILIGHQRRIVSSIQTLRLHMMHIQEKGFHV
What is the function of this protein?
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
What are the official names of this protein?
Ephrin type-A receptor 6, EPH homology kinase 2, EHK-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: NU3M_RAT
Sequence: MNLLIIITINITLSFILISIAFWLPQMNLYSEKANPYECGFDPTSSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQTTNTTTMMATAFILVTILALGLSYEWTQKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ENO2_LACPL
Sequence: MEKQVIETVKAREIFDSRGNPTVEADVILSDGTLGRAEVPSGASTGEKEAVELRDGGDRLAGKGVLKAVNNVNTVINHALHGADPFNQAHIDQIMIDLDGTPNKARLGANAILGVSMATARAAANALQQPLYRYLGGTDLELPQTFHNVINGGEHADNGIDIQEFMITPVERTSFRDGFEKIVNTYHTLKKVIEDAGYTSGLGDEGGFAPDLKNSEEALQMLHDAIIKAGYTPGKEIAIAFDAAASYFYNRTTHNYDFEGKTYTPAALGDYYLQLLAKFPEIVSIEDPYGEEDWDNFASFTAAHGDQLQIVADDPVCTNPQLIRQAIQRGMANNILIKLNQIGTVTETLAAIRLARKNGYATMMSHRSGETGDTFVADFTVATNAAQLKAGAPARSERVEKYNQLLRIEEELGADGARLAHFPNNVMFD
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase 2, 2-phospho-D-glycerate hydro-lyase 2, 2-phosphoglycerate dehydratase 2.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RPOA_DRANE
Sequence: MVREKVKVSTRTLQWRCVESRRDSKRLYYGRFILSPLMKGQADTIGIAMRRALLGEIEGTCITRAKSENIPHDYSNIVGIQESVHEILMNLNEIVLRSNLYGTRNALICVQGPGYITARDIILPPSVEIVDNTQHIATVTESIDLCIGLKIERNRGYSLKMSNNFEDRSYPIDAVFMPVQNANHSIHSYGNGNGKQEILFLEIWTNGSLTPKEALHEASRNLINLFIPFLHVEEETFHLENNQHQVTLPLFPFHNRLVNLRKKKKELAFQYIFIDQLELPPRIYNCLKKSNIHTLLDLLNNSQEDLIKIEHFHIEDVKKILDILEKK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UL129_HCMVA
Sequence: PDLHLLYPSQSHRLSPSRAQGILKTARHESQRPDAVLDDVVAAIGSQPRAAGARRRMLRIHKRQPPAGTLLRFQNVQSLHRRVRIFMIVCVLWCVWICLSTFLIAMFHRRSSGMPE
What are the official names of this protein?
Uncharacterized protein UL129.
Protein: UPP_STRPN
Sequence: MGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEVLRDLPLEDVEIETPITKTVQKQLAGKKLAIVPILRAGIGMVDGLLNLVPAAKVGHIGMYRDEETLQPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASNIKFVCLVSAPEGVKALQEAHPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: YGFX_ECOLI
Sequence: MVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQEWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
What is the function of this protein?
A probable inner membrane protein.  Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression (PubMed:23657679).  Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization as well as MreB ATP-dependent polymerization (PubMed:22239607).  Restores production of prodigiosin antibiotic (Pig) in Serratia strains with deletions of sdhE-ygfX; overexpression of this protein and CptB also restores Pig production to a slightly lesser extent in Serratia (PubMed:22474332).
What are the official names of this protein?
Inner membrane protein YgfX, Toxin CptA.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y047_METJA
Sequence: MEIIFRGAALEVGRSCIEIKTDKSKILLDCGVKLGKEIEYPILDNSIRDVDKVFISHAHLDHSGALPVLFHRKMDVPVITTELSKKLIKVLLKDMVKIAETENKKIPYNNHDVKEAIRHTIPLNYNDKKYYKDFSYELFSAGHIPGSASILLNYQNNKTILYTGDVKLRDTRLTKGADLSYTKDDIDILIIESTYGNSIHPDRKAVELSFIEKIKEILFRGGVALIPVFAVDRAQEILLILNDYNIDAPIYLDGMAVEVTKLMLNYKHMLNESSQLEKALKNVKIIEKSEDRIKAIENLSKNGGIVVTTAGMLDGGPILYYLKLFMHNPKNALLLTGYQVRDSNGRHLIETGKIFIGKDEIKPNLEVCMYNFSCHAGMDELHEIIKKVNPELLIIQHGEEVQATILRNWALEHGFDAITPKLGEKIRI
What are the official names of this protein?
Uncharacterized protein MJ0047.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family.