PharMolix/UniProtQA huggingface dataset:
Protein: PHNC1_ALBFT
Sequence: MGIAISINALNKTFRGGRKALHDIHLDIKAGEMVALIGASGSGKSTLLRHMAGLMAGDGAGQGLIQIHGQTVQQNGRIAADIRRTRAGVGFVFQQFNLVDRLPVIVNVLAGTLHRVPLWRSLLRWFTPSEVARGVEALRRVGIAECCAQRASTLSGGQQQRAAIARAMVQGARVILADEPIASLDPESSRKVMDILARVNREDQCTVVVSLHQVNVAIKYCPRTVALHQGRVVYDGPSVALTPTLLRELYGADADDILALGDHITSLQDNKPVAPHLVWPAALAARAPLASAA
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS9_BACAC
Sequence: MAQVQYYGTGRRKSSVARVRLVSGEGRVIINGRDFENYIPFAALREVVKQPLVATETLGNYDVLVNVNGGGYTGQAGAIRHGISRALLKADPEYRLTLKRAGLLTRDARMKERKKYGLKGARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: FTSK_VIBVU
Sequence: MFKENAKKVQTIIKTSEEAQSSRLNGFQRLKECCLILGVLTSAFLSIALLTFSPADPSWSQTSWGGDISNAGGQFGAWVADTLFFTFGLLAYLLPVLLVIVTWVFFRTRDEDEHIDLMLWGTRLLGLAILILTSCGLADINFDDIWYFSSGGVLGDVLNSLALPTLNLLGTTLVLLFAWGAGFTLLTGISWLSIVEWIGSLFLDVCQWALNRLRGEKTEVIAPELQPIALSDDEPKAQPQIEAQQDEIVEEERIPDPLPVEPVVQMRREYPIHMPQTVSYQTVSDELDELEDNSFERAKKLNATIEELEQEALSVNDLPDDTMSTERARYNVADIAQVSAEHSQTTQVEHAQDFSVDVEEFDHVISLSELDKISEEIDEPVMVGFAEEAPLHHNEAQRSAMASSAEPMFSHLGVEQTTQHTTQEEIVDLPVADSVGDVNPEMEDYVEEDEDQDQDVVAFQNMVSKAQQNMAATQNPFLMKQDTSLPVPKEPLPTLELLYHPEKRENFIDKEALEQVARLVESKLADYKITAEVVGIFPGPVITRFELDLAPGVKVSRISSLSMDLARSLSAMAVRVVEVIPGKPYVGLELPNMSRQTVYLSDVIDSPQFQNATSPTTVVLGQDIAGEALVADLAKMPHVLVAGTTGSGKSVGVNVMILSMLYKASPEDVRFIMIDPKMLELSVYEGIPHLLAEVVTDMKDASNALRWCVGEMERRYKLMSVMGVRNIKGFNEKLKMAADAGHPIHDPFWQEGDSMDTEPPLLEKLPYIVVVVDEFADLMMVVGKKVEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRVAFTVSTKTDSRTILDQGGAESLLGMGDMLYLPPGSSHTIRVHGAFASDDDVHAVVNNWKARGKPNYIDEIISGEQGPESLLPGEQMESDEDLDPLFDQVVEHVVQSRRGSVSGVQRRFKIGYNRAARIVEQLEAQGIVSAPGHNGNREVLAPAPPRE
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination.  FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation.  FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: GH_ELHVK
Sequence: MLIRRRALWLTIPILIIMTSHKIMCAFDLSHVHSESCLKIQDISSDTINFTPNLVMFRFFSNETHSDVFHLPKCIFDSKLTSYLFDHLNIYEDVSVYKNNFEKYYMGSVEGTYRTIIIKGEDTTPYLDKTTAPTVEITEKDLIITYQGIRYMNPFPVLSLIDDESCEVFDDINELILPYFGKCRKFYLNFGSVTLFGHITSNFVTIKYTAQNGTDPYTIRLFFGNSAEIVHTLPFEAQDLALRMMMYDDFEIIGEVGPVKEMLKSFKLSLLDSLLEQNHEDVMNDFRHVFEAFYNHIKKIRDGSIDIKSLHIEQLLDSLLAYSIGYYIQYRYPPYTGKWRGIEHFIETETYIHMVPELFDLFAHNMTVKTPTRPNAIKFINILIRLYSYTDYTKLDHRGLSLYFLKYIYQGNVTDDIATYAHRYMTNLYTKYTYPKTQEGEHLYKSYNDSLDTFILNTIGLKSKNKTLLHHILLLQTGMCNIQNMIGHFHSLQNNDPKFGALLSPCYRSLRYDLTAKKIGQLITKESLEPYGRLVNMVRFMTKNSSMLNVLKCELPEDDGLLAIATVDNKTYIISSRPIAVGVVYKATYTAINLFLYVTRIQNNTCIHIDKVYRDGDVKAVYTFSLDTAKDCGDMCPSVLVEYQTNTGFIGIHVINSIADIQYISENRKLFPESSHYLWLLKNDTVLELEGTNFFLFSSKSPGAIVLYIIIISLIVWTLYEIIKLFCYKRQWQYQKL
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL.  May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein H, gH.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein H family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: INRA2_ONCMY
Sequence: MGPWTLLLLHLPLVVSMLPAPTNVSIVSFNLEHTLTWLPGPETPDNTHFTVQSLRKNSWQLVKGCARLKTRQSCDLTNTFKDPFYHYKARVQAITTTQKSNRSLSMLFYPLTDTLLGPPVVSVSGCGNCPLLQVTPPTSRGLQRSLSPTQLYYRQFTCKVRRTRDGSQFSMWVTSTEKTVIGYLEPGAEYCVTVTPSTSFNPHSVPSEPHCAFTSPTAANTVPVVLSVLCAFSLLVVLLCGIVVYSGRLLCMHKPLPKTLSSVPLCGG
What is the function of this protein?
Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:24244163).  Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response.  Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another.  The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT).  STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity).
What are the official names of this protein?
Interferon alpha/beta receptor 2, Type I interferon receptor 2.
What is the protein family that this protein belongs to?
Belongs to the type II cytokine receptor family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: PI2R_BOVIN
Sequence: MADSCRNLTYVRDSVGPATSTLMFVAGVVGNGLALGILGARRHSRPSAFAVLVTGLGVTDLLGTCFLSPAVFAAYARNSSLLGLARGRPALCDAFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRRARLALPAIYAFCTIFCSLPFLGLGQHQQYCPGSWCFIRMRSAEPGGCAFLLAYASLVALLVAAIVLCNGSVTLSLCRMYRQQRRHQARCPRPRAGEDEVDHLILLALMTGIMAVCSLPLTPQIRGFTQAIAPDSSEMGDLLAFRFNAFNPILDPWVFILFRKSVFQRLKLWFCCLYSRPAQGDSRTSLSQSASGRKDSSAPPALEGKKGNWVPLSAWGEGQGGPLPAVQLPTSTVGTPSKAGSEAACSLC
What is the function of this protein?
Receptor for prostacyclin (prostaglandin I2 or PGI2).  The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
What are the official names of this protein?
Prostacyclin receptor, Prostaglandin I2 receptor, PGI receptor, PGI2 receptor, Prostanoid IP receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MIA40_DANRE
Sequence: MSYCKQEGKDCIIFVTKEDHEAPSNAELVEDDPNDPYEDHGLILPNGDINWNCPCLGGMASGPCGQQFKDAFSCFHYSKEEIKGSDCVENFRGMQECMQKYPELYPQEDDNDSAPSGGANTAPTDSLPASSTDSTAAAATENPATS
What is the function of this protein?
Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity).  Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1.  Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS).  Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.
What are the official names of this protein?
Mitochondrial intermembrane space import and assembly protein 40, Coiled-coil-helix-coiled-coil-helix domain-containing protein 4.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: GCS1_SCHPO
Sequence: MVSDMLGGNKRWILFGLLSFLLNCVLVSCSVEDIEKAANDSFLWGPYRPNLYVGIRPKIPDSLMTGLMWSNVDDYARFSKMRHSAEHGDDIGAFGWKHYDVRRGGQQVIDDFLMGIKLETDFVKLPEGNWALRVHGIPLPGAPTDLTTSLFFYAYVEGEGKVGTKVNHANHVYMEGKTPDLGKFRIQTFNRLGEHPVSPASVDLESMVMDKDFFAGFNVKKEGAWRTSELILYLLDTKMKVISDKEGYESLKDLPPAYSTLTLPNLPSEEGLQFIQKVFKGEFMFDIVFNYASSKKISEEMISQAIDKNLQEFEEKFQATFPLKAPYDTEKAHQIFAHTAFSNLFGNVGFFTGDSIVSKNPIELDDEDYEFMQGFESAAGKLAEGTAFHDIERSLFTIVPSRPHFPRGFYWDEGFHLLPVGLWDNDFSLEILKSWFSLVNEDGWVGREQILGEEARSKVPDEFQTQYPDIANPPTLILALKGYIERLQEQQGKLNNRFSGEGEDYSLDDLEYLRSVSISNPEKSVQFLRDLFPLLLRHYEWFRETQKGDFETWERECFSQVEGYRWRGRTYQHCLASGLDDYPRAQPPSTAELHVDLLSWMTSFTRSLHFVAEFLGETEEAEKLAGYENAMLRNLEDNHWDEEVQAYCDSSVDEYDDPINVCHKGYVTLLPMMLGLLPADSGRLTSLLKLIRDENELWSPYGIRSLSMNDVYFGTGENYWRGPIWINMNYLILSSLYQNYINTPGPNQNLARSIYEELRTNVVNNVFENWRQTGIFWEQYDPTTGKGQRTKDFTGWTSLVVNIMSENY
What is the function of this protein?
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically.
What are the official names of this protein?
Probable mannosyl-oligosaccharide glucosidase, Processing A-glucosidase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 63 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: MED18_DROME
Sequence: MAIVSSARESLSHAMNNRFLPNLEYLLQGSILDSAVEHLMHRLKGLCDNVDTSPEPFHDLEVCMSLRQPNANQPLLLRVRRALGRDAPFQMRYLGNPEVDLRRPTLVRSCMDCACTNGILEFLTEMGFRLEFEYIAKGYMFRKGRMKITVSKLIKIVPGKQQDMANEPISQSYIVELSVVAPTGQENVGEEMRVFAEQLKPLVQLEKIDYKRLGGMP
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 18, Mediator complex subunit 18, dp28b.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MCE_MIMIV
Sequence: MGTKLKKSNNDITIFSENEYNEIVEMLRDYSNGDNLEFEVSFKNINYPNFMRITEHYINITPENKIESNNYLDISLIFPDKNVYRVSLFNQEQIGEFITKFSKASSNDISRYIVSLDPSDDIEIVYKNRGSGKLIGIDNWAITIKSTEEIPLVAGKSKISKPKITGSERIMYRYKTRYSFTINKNSRIDITDVKSSPIIWKLMTVPSNYELELELINKIDINTLESELLNVFMIIQDTKIPISKAESDTVVEEYRNLLNVRQTNNLDSRNVISVNSNHIINFIPNRYAVTDKADGERYFLFSLNSGIYLLSINLTVKKLNIPVLEKRYQNMLIDGEYIKTTGHDLFMVFDVIFAEGTDYRYDNTYSLPKRIIIINNIIDKCFGNLIPFNDYTDKHNNLELDSIKTYYKSELSNYWKNFKNRLNKSTDLFITRKLYLVPYGIDSSEIFMYADMIWKLYVYNELTPYQLDGIIYTPINSPYLIRGGIDAYDTIPMEYKWKPPSQNSIDFYIRFKKDVSGADAVYYDNSVERAEGKPYKICLLYVGLNKQGQEIPIQFKVNGVEQTANIYTKDGEATDINGNAINDNTVVEFVFDTLKIDMDDSYKWIPIRTRYDKTESVQKYHKRYGNNLQIANRIWKTITNPITEDIISSLGDPTTFNKEITLLSDFRDTKYNKQALTYYQKNTSNAAGMRAFNNWIKSNMITTYCRDGSKVLDIGCGRGGDLIKFINAGVEFYVGIDIDNNGLYVINDSANNRYKNLKKTIQNIPPMYFINADARGLFTLEAQEKILPGMPDFNKSLINKYLVGNKYDTINCQFTIHYYLSDELSWNNFCKNINNQLKDNGYLLITSFDGNLIHNKLKGKQKLSSSYTDNRGNKNIFFEINKIYSDTDKVGLGMAIDLYNSLISNPGTYIREYLVFPEFLEKSLKEKCGLELVESDLFYNIFNTYKNYFKKTYNEYGMTDVSSKKHSEIREFYLSLEGNANNDIEIDIARASFKLAMLNRYYVFRKTSTINITEPSRIVNELNNRIDLGKFIMPYFRTNNMFIDLDNVDTDINRVYRNIRNKYRTTRPHVYLIKHNINENRLEDIYLSNNKLDFSKIKNGSDPKVLLIYKSPDKQFYPLYYQNYQSMPFDLDQIYLPDKKKYLLDSDRIINDLNILINLTEKIKNIPQLS
What is the function of this protein?
Responsible for methylating the 5'-cap structure of mRNAs.
What are the official names of this protein?
Probable mRNA-capping enzyme.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Virion.
Protein: HSLV_BREBN
Sequence: MEQFHATTIFAVQHNGSVAMAGDGQVTFGNSMVMKHGAKKVRRLYRGEVLAGFAGSVADAITLFEKFEGKLEEYHGNLQRAAVELAKEWRMDKILRRLEAMMIVANKEHLLLISGNGEIIEPDDGILAIGSGGSFALAAGRALKTYAPHLGAREIAEASLRTAAEICVFTNNNLVVDELN
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBE_MOUSE
Sequence: MVNFTAEEKTLINGLWSKVNVEEVGGEALGRLLVVYPWTQRFFDSFGNLSSASAIMGNPRVKAHGKKVLTAFGESIKNLDNLKSALAKLSELHCDKLHVDPENFKLLGNVLVIVLASHFGNEFTAEMQAAWQKLVAGVATALSHKYH
What is the function of this protein?
Hemoglobin epsilon chain is a beta-type chain found in early embryos.
What are the official names of this protein?
Hemoglobin subunit epsilon-Y2, Epsilon-Y2-globin, Hemoglobin epsilon-Y2 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: COAD_MYCVP
Sequence: MSGAVCPGSFDPVTLGHIDIFERAAAQFDEVVVAVMVNPNKTGMFTHEERIALIEESTTHLPNLRVESGQGLIVDFVKARGLTAIVKGLRTGTDFEYELQMAQMNNHIAGVDTFFIATTPRYSFVSSSLAKEVATLGGDVSELLPAPVNARLKAKLAARD
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADAT1_HUMAN
Sequence: MWTADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPADKACDTPDKPVQVTKEVVSMGTGTKCIGQSKMRKNGDILNDSHAEVIARRSFQRYLLHQLQLAATLKEDSIFVPGTQKGVWKLRRDLIFVFFSSHTPCGDASIIPMLEFEDQPCCPVFRNWAHNSSVEASSNLEAPGNERKCEDPDSPVTKKMRLEPGTAAREVTNGAAHHQSFGKQKSGPISPGIHSCDLTVEGLATVTRIAPGSAKVIDVYRTGAKCVPGEAGDSGKPGAAFHQVGLLRVKPGRGDRTRSMSCSDKMARWNVLGCQGALLMHLLEEPIYLSAVVIGKCPYSQEAMQRALIGRCQNVSALPKGFGVQELKILQSDLLFEQSRSAVQAKRADSPGRLVPCGAAISWSAVPEQPLDVTANGFPQGTTKKTIGSLQARSQISKVELFRSFQKLLSRIARDKWPHSLRVQKLDTYQEYKEAASSYQEAWSTLRKQVFGSWIRNPPDYHQFK
What is the function of this protein?
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
What are the official names of this protein?
tRNA-specific adenosine deaminase 1, hADAT1, tRNA-specific adenosine-37 deaminase.
What is the protein family that this protein belongs to?
Belongs to the ADAT1 family.
Protein: RS14_NOSP7
Sequence: MAKKSMIEREKKRTRLIEKYADKREALLEEFRSAASPLDKLEIHRKIQQLPRNSAPTRHRNRCWLTGRSRGVYRDFGLSRNVLREWAHEGLLPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: HIS8_DESVV
Sequence: MTAPSMSRPDDVRPEVLDFKPYVPGLSIDEIRDRFGLADVVKLASNENPLGTSPVVQRTLKTKADLAFRYAQSGNPRLTRAIAAHHGVAPERVVAGNGSDEIIDLLIRVRATPGKHNIVAFRPCFSIYELQAKFCGLEFRQADLRPDFTFDWDAFLAATDENTAIAFVTTPDNPSGWCPPVSELEHVARTLPPSCLFVIDEAYMDFCGDEAAHSLLSRLDAFPNIAVLRTFSKSFGLAGLRLGYGILPERLADYLHRVRLPFSVNILAEEAGLAALEDTVFRSETLRVTAEGRAYIAEGLTALGCEVLPSWANFIMFRPPTDATDLFEALLRRGIIIRPLKSYGLPQHLRVSMGNADENRRFIAACKEILPHA
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: PRTK_PARAQ
Sequence: MRLSVLLSLLPLALGAPAVEQRSEAAPLIEARGEMVANKYIVKFKEGSALSALDAAMEKISGKPDHVYKNVFSGFAATLDENMVRVLRAHPDVEYIEQDAVVTINAAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQMVKTYYYSSRDGNGHGTHCAGTVGSRTYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQSSGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTSILSTWIGGSTRSISGTSMATPHVAGLAAYLMTLGKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA
What is the function of this protein?
Hydrolyzes keratin at aromatic and hydrophobic residues.
What are the official names of this protein?
Proteinase K, Endopeptidase K, Tritirachium alkaline proteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
Protein: LEPA_CAMHC
Sequence: MENIRNFSIIAHIDHGKSTLADRLISECNAVEDRQMSSQVMDTMDIERERGITIKAQSVRLEYKMNDKKYILNLIDTPGHVDFSYEVSRSLASCEGAILVVDASQGVQAQTIANVYIAIEHNLEIIPVLNKIDLPNADPDRVKNEIEHIIGIDCTDAIEVSAKTGIGIKDLIEAIIKRIPAPKIEPKKPLKAIIYDSWFDNYLGALALIRVYDGEIHKNDEVFIMGTEKKHIVLDLMYPNPISPIKTEKISSGEIGIVVLGLKNVSDVSVGDTITLSNNKANTPIGGFERAKPFVFAGIYPIETDKFEDLRDALNKLKLNDSSISYEPETSLALGFGFRVGFLGLLHMEVIKERLEREFNLNLIATAPTVTYEIYLTNGEMLKIHNPSELPPISNIQMIKEPYSHATIITPAEFLGNLITLLNSRRGIQTKMDYITSDRVLLEYDIPTNEIIMDFYDKLKSGTKGYASFDYEPIDYKQGDLIKLDIKVAGENVDALSIIVPRDKALQKGRDLVKAMKEIVPRQLFEVAIQASIGNKIIARENVRAMGKNVTAKCYGGDITRKRKLLEKQKEGKKRMKSIGKVNLPSEAFLSVLKID
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: END4_CHLTR
Sequence: MFILPPPQEALLGAHTSAAGGLHNALYEGRDIGATTVQLFTANQRQWKRRTLTQEMVDQFRIALNETSLSYIMSHAGYLNNPGAPNPEILEKTRVCMHQEIADCISLGISFVNFHPGAALSDSKESCLDRTIASFSQMAPLFENNPPLVVLLETTAGQGSLIGSSFEELAYLIQGIKAHIPIGVCLDTCHIFAAGYDISSVAGWEQVLKHFDAVIGLSFLRAIHLNDSVFALGKNKDRHAPIGEGCIGSDSFCFLMQDERTRMLPKYLETPGGPDLWTKEIRYLQKVC
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: MAP2_ASPOR
Sequence: MGSKTFEGEGQRGGNDPSNSTSPNSAGGEPRGAHLSRDGDGSLGDGDGDDGADGDEKDGAVTTTPLTEQQPSSETTSKKKKRRKPKKKISALKQSSPPRVPLDDLFPTGQFPVGETHEYGSVVEGTARTTSEEVRYLSRNYLQDDSVLTDYRKAAEIHRQVRHWTQENVRPGQTLTEIAVGIEDGVRALLDNAGLETGQCLQSGMGFPTGLALNDCVAHYTPNPGQKDIVLQASDVMKVDFGVHINGWIVDSAFTMSFDPTYDNLLAAVKDATNTGIKNAGIDVRISDVSAAIQEAMESYEVEIGGKVFPVKPVRDISGHNINRYQIHGGKSIPFVKNSSQTKMEEGEIFAIETFGSTGRGSTVEGFGVYGYGKDPNAPKKVSSPLASARSLYKTINENFGSIVFCRRYLERLGVERYLAGMNSLVNNGIVEQYAPLMDMKGSYSAQFEHTILLRESCKEVVSRGNDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2, MAP 2, MetAP 2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECY_STRCO
Sequence: MLTAFARAFKTPDLRKKLLFTLGIIVVYRLGTHIPIPGVDYKNVQECVDQASGNQGLFGLVNMFSGGALLQITVFALGIMPYITASIILQLLTVVIPRLEALKKEGQAGTAKITQYTRYLTVALAILQGTGLVATARSGALFSGCTVAGQIVPDQAIFTTVVMVICMTAGTCVVMWLGELITDRGIGNGMSILMFISIAATFPSALWAIKKQGELADGWIEFGTVILVGLVMVGLVVFVEQAQRRIPVQYAKRMIGRRSYGGTSTYIPLKVNQAGVIPVIFASSLLYIPALIVQFSNSTAGWATWITKNLADTAATPHIILYFFLIVFFAFFYVAISFNPEEVADNMKKYGGFIPGIRAGRPTAEYLSYVLNRITWPGSLYLGLIALVPTMALAGFGANQNFPFGGTSILIIVGVGLETVKQIESQLQQRNYEGFLR
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUDL_ECO57
Sequence: MEYRSLTLDDFLSRFQLLRPQINRETLNHRQAAVLIPIVRRPQPGLLLTQRSIHLRKHAGQVAFPGGAVDDTDASVIAAALREAEEEVAIPPSAVEVIGVLPPVDSVTGYQVTPVVGIIPPDLPYRASEDEVSAVFEMPLAQALHLGRYHPLDIYRRGDSHRVWLSWYEQYFVWGMTAGIIRELALQIGVKP
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Uncharacterized Nudix hydrolase NudL.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Protein: LACB_STRA5
Sequence: MKIAVGCDHIVTYDKIAVVDYLKTKGYEVIDCGTYDNIRTHYPIYGKKVGEAVASGKADLGVCICGTGVGINNAVNKVPGIRSALVRDLTSAIYAKEELNANVIGFGGKITGGLLMTDIIEAFIRAKYKPTKENKVLIEKIAEVETHNAHQEENDFFTEFLDKWNRGEYHD
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacB.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: MURI_CORDI
Sequence: MNNAPIGIFDSGVGGLTVARVIMEQLPNESVIYIGDTANSPYGPKPIAQVRELSLAIGEELVRRGCKMIVIACNTATSAALRDLRERFDVPVLGVILPAVRRAVSTTRNGKIGVIGTEGTIKSGAYQELFAASPSVEVHAQACPSFVSFVERGITSGRQILGVAQGYVEPLQAAGVDTLVLGCTHYPLLTGVIQLAMGDRVTLVSSAEETAKDVFKTLSMTDMLASEDSTPVRTFESTGDPVLFAQLAERFLGPHVTNVEKFAGM
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.