PharMolix/UniProtQA huggingface dataset:
Protein: RENBP_PIG
Sequence: MEKERETLQAWKERVGQELDRVMAFWLEHSHDREHGGFFTCLGRDGRVYDDLKYVWLQGRQVWMYCRLYRKLERFHRPELLDAAKAGGEFLLRHARVAPPEKKCAFVLTRDGRPVKVQRSIFSECFYTMAMNELWRVTAEARYQSEAVDMMDQIVHWVREDPSGLGRPQLPGAVASESMAVPMMLLCLVEQLGEEDEELAGRYAQLGHWCARRILQHVQRDGQAVLENVSEDGEELSGCLGRHQNPGHALEAGWFLLRHSSRSGDAKLRAHVIDTFLLLPFRSGWDADHGGLFYFQDADGLCPTQLEWAMKLWWPHSEAMIAFLMGYSESGDPALLRLFYQVAEYTFRQFRDPEYGEWFGYLNREGKVALTIKGGPFKGCFHVPRCLAMCEEMLSALLSRLA
What is the function of this protein?
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:8663114).  Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity).
What are the official names of this protein?
N-acylglucosamine 2-epimerase, AGE, GlcNAc 2-epimerase, N-acetyl-D-glucosamine 2-epimerase, Renin-binding protein, RnBP.
What is the protein family that this protein belongs to?
Belongs to the N-acylglucosamine 2-epimerase family.
Protein: CAS10_ENTI1
Sequence: MNKKLELMYGSLLHDIGKIVYRSNSVDFAKGTHSKIGSQFLNKFKPFQLSGIVDSVSYHHYKELASSSLLDDSVAYITYIADNIASGTDRRASEGDYEGEGNRQRFDKRAPLASIFNVVNSETKGLANYTYSFEKEQVYRYPTDAKKEYTSSQYAALVNKMTDDLSNKLKVGPDSFSSLLQWTESLWSYIPSSTDTNQVMDVSLYDHSKITCAIASCIYDYLTEMNCVNYRKELFSPYEKTKQFYQEDVFLLVSLDMSGIQDFIYNISGSKALKSLRSRSFYLETMLESLVDDLLSDLELSRANLLYTGGGHAYLLLPNTERARDVLASFEGEMKEWFIKIFKTDLSVAIAYKACTGEDLMNSNGTYSDLWQTVSRKLSDKKAHKYSLNEIKLFNSTIHAGTQECKECLRSDIDISEDSLCKICEGIIAISNDLRDYSFFVVSPEGKVPLPRNRYLSVENQDGAERKIKMNKETRIYSKNQPFVGKQLVTNLWMCDYDFSTLNPETKKQGIASYVNREVGIPRLGVLRADIDNLGTTFIKGIPEQYRSISRTATLSRQLSMFFKFELSNILKGARISVIYSGGDDLFLIGAWDDVISKALVLRKAFTRFSAGKLTFSAGIGMYPVKYPISKMASETGVLEDLAKRGEKNQVALWNDSKVFGWSQLEEQILKEKMIPLQEALTNSQEHGKSFLYKMLELLRNEDQINIARLAYLLARSSLSEELTQSIFAWSQNKQQKVELITAIEYLVYQIREAD
What is the function of this protein?
When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP, producing (mostly) cyclic hexaadenylate (cA6).  cA6 synthesis occurs in the Csm effector complex and requires cognate target RNA and ATP; other NTPs are not incorporated.  cOAs are second messengers that induce an antiviral state important for defense against invading nucleic acids.
What are the official names of this protein?
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ssDNase Cas10, Cyclic oligoadenylate synthase, EiCas10.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Cas10/Csm1 family.
Protein: MSHB_STRCO
Sequence: MTDLPGRRLLLVHAHPDDESINNGVTMARYAAEGAHVTLVTCTLGERGEVIPPALAHLSGAALGGHRRGELADAMRALGVDDFRLLGGPGRYADSGMLGLSDNDDPGCLWQADVDAAAALLVDVIREVRPQVLVTYDPNGGYGHPDHIQAHRIAMRAAELAAEAGCPVAKVYWNRVPRSRVEDAFARLRDDLPGLPFEKAAGVEDVPGVVDDERITTEIRGEGTAYAAAKAAAMRAHATQITVAEPYFVLSNDLAQPILTTEYYELVRGERGGEGRENDLFAGIAGTFDTGEATS
What is the function of this protein?
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
What are the official names of this protein?
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, GlcNAc-Ins deacetylase, N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family.
Protein: APT_NOVAD
Sequence: MTTDDLKRLVRTVPDFPSPGILFRDITTLIAHGEGLSACIDHLAHKARAAGAQAVAGMEARGFIFGAAVAARMGLGFIPVRKPGKLPVKTIGIDYALEYGRDRLEIDPTAIREGQRVVIVDDLIATGGTALAAAELLRMAGAHVTHALFVIDLPELHGAERLRGAGLTVEALMDFPGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DABA2_NITWN
Sequence: MVDALNLGRRLRVRSTAYVASELVPFFWPMRNFISRNPLRRLESMPFEQAVRRGAALFHARMFLPRGDYQRWRREGKVRPETLDEEIGRRSQDLPPVPGVDWPRWLHALMQTPHDRDAVVRGVRAKDVHAALRGHPPSAQAVDVAALLPELEQRLHARTLPEAVDALWGTGLADELDDLVIKSYLDFFDEDQSAWRMPGRERGLFSAWSEVTRRNARMVLRRLHVRHILDHVQDAESAVVYVMEEMGIGAEAWPTYFTRVLTRLHGWTGFVRWRASAKHYYWAQQYPADIVDLLAIRLVMGLALLQESARHRGTPMRRDDLGAVVRERGAECVLRYALHSGEVLPDWAQRIDDTLSRGNGARCHDLLQRYWPLWQARLGQQQAAALRELAAAANATAALDALAPEDVEGLLQGLRDFAPQEGMVWTLAMEGQAIDKLLTQVQAPQDPPPDKRPFAQALFCIDVRAEPIRRHLERVGNYQTFGIAGFFGVPVGFLGYGKGSESHYCPAVITPKNLVLELPAALDPHNEDFVSTLGHVLHDLKKSVLSPYVTVEAVGMLFGLDLFGKTLAPLGYSRWRRRIDTEKPVTRLLVDKLSREQADSIIRTLQRAMIVKALHTELKIERERVDSGIIRELREIALRRRDGPTRLRTTFGVPQTQETEFIDKLRQVYGVDADYTNHQLERLGRIGYSLDEQVNYVHTALTMIGLTQTFSRFVLVVGHGGKTENNPYESALDCGACGGASGIVNARVFAQMANKAAVRERLAAMGITIPEDTWFMPALHVTTTDAIELFDLDLLPPRHLVYLERLRNSLRAASRLTAAERMPKLLPEAKALEPAEALRLANRLAVDWAQVRPEWGLSGNVYGIVGRRALTENSDLQGSAFLLSYDWRCDPRGRLLENLLTGPVVVGQWINLEYFFSTVDNSRLGSGSKVYHNVSGRFGVMTGSLSDLRTGLPMQTVMREGRPYHEPMRLIALIEAPLDFAGRVLERVVKVKSLVLGGWIRAIVIDPTQGYKPFVFNNGQWEERTPLIAPAEKEYSA
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA 2.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATPE_STAAT
Sequence: MNTLNLDIVTPNGSVYNRDNVELVVMQTTAGEIGVMSGHIPTVAALKTGFVKVKFHDGTEYIAVSDGFVEVRKDKVSIIVQTAETAREIDVERAKLAKARAESHLENDDDNTDIHRAERALERANNRLRVAELK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YUC8_ARATH
Sequence: MENMFRLMDQDQDLTNNRCIWVNGPVIVGAGPSGLATAACLHEQNVPFVVLERADCIASLWQKRTYDRLKLHLPKQFCQLPKMPFPEDFPEYPTKRQFIDYLESYATRFEINPKFNECVQTARFDETSGLWRVKTVSKSESTQTEVEYICRWLVVATGENAERVMPEIDGLSEFSGEVIHACDYKSGEKFAGKKVLVVGCGNSGMEVSLDLANHFAKPSMVVRSSLHVMPREVMGKSTFELAMKMLRWFPLWLVDKILLVLSWMVLGNIEKYGLKRPEMGPMELKSVKGKTPVLDIGAIEKIRLGKINVVPGIKRFNGNKVELVNGEQLDVDSVVLATGYRSNVPYWLQENEFFAKNGFPKTVADNNGWKGRTGLYAVGFTRKGLSGASMDAVKIAQDIGSVWQLETKQPTKRSRGSLRRCISQQF
What is the function of this protein?
Involved in auxin biosynthesis.  Belongs to the set of redundant YUCCA genes probably responsible for auxin biosynthesis in roots.
What are the official names of this protein?
Probable indole-3-pyruvate monooxygenase YUCCA8, Flavin-containing monooxygenase YUCCA8.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
Protein: RNC_CUPPJ
Sequence: MNLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKLDEGDLSRVRANLVKQQALYEIAQMLQLSEVLRLGEGELKSGGFRRPSILADALEAIVGAVFLDAGFEAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPQYNVIATHGAAHSQQFEVECMVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTRKQPVPPDPQLSLRLKE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TEKT2_MESAU
Sequence: LPLDVAIECLTLRESRRDIDVVRDPVEEELLKEVEVIEATKKALQQRVSQAFQQLCLLQEVRQQLCSDHRDKMESLDIDRGCLSLNL
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme.  Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia.  Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
What are the official names of this protein?
Tektin-2, Tektin-t, Testicular tektin.
What is the protein family that this protein belongs to?
Belongs to the tektin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Colocalized with CCDC172 at the perinuclear region.
Protein: MURG_STAAR
Sequence: MTKIAFTGGGTVGHVSVNLSLIPTALSQGYEVLYIGSKNGIEREMIESQLPEIKYYPISSGKLRRYISLENAKDVFKVLKGILDARKVLKKEKPDLLFSKGGFVSVPVVIAAKSLNIPTIIHESDLTPGLANKIALKFAKKIYTTFEETLNYLPKEKADFIGATIREDLKNGNAHNGYQLTGFNENKKVLLVMGGSLGSKKLNSIIRENLDALLQQYQVIHLTGKGLKDAQVKKSGYIQYEFVKEDLTDLLAITDTVISRAGSNAIYEFLTLRIPMLLVPLGLDQSRGDQIDNANHFADKGYAKTIDEEQLTAQILLQELNKMEQERTRIINNMKSYEQSYTKEALFDKMIKDALN
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NDHI_OENEH
Sequence: MFPMVTGFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETGVRKKRLLNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTILNSAQIK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RIFK_METJA
Sequence: MIIEGEVVSGLGEGRYFLSLPPYKEIFKKILGFEPYEGTLNLKLDREFDINKFKYIETEDFEFNGKRFFGVKVLPIKILIGNKKIDGAIVVPKKTYHSSEIIEIIAPMKLREQFNLKDGDVIKILIKGDKDE
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).  Can also utilize UTP as the phosphate donor, although less efficiently, and it is unclear if ATP and GTP can also serve as substrates (PubMed:18245297) or not (PubMed:18073108).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: GLMM_BLOFL
Sequence: MKRSKYFGTDGIRGRVGLSPITPDFILKLGWAAGKVLSNYGSGRSKQVIIGKDTRISGYMLESALEAGLAASGLSAALTGPMPTPAIAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIKGTKLDTQVEYFIETELNKCLKCIQPKLLGKAKRIIDAAGRYIEFCKGTFPAHLSLKKLRIVVDCANGATYHIAPNVLRELGADVIAISCNPNGININNKCGSTDIRRLRTQVLLKKADLGIAYDGDGDRVIMVDHIGNKVDGDQMLYILAKEYLYQRKLHGGIVGTWMSNMGLALALRELNIPFVRANVGDRSVLLMLREKGWYIGGENSGHIVLLDKTTTGDGIIVALQILSTMVSNSVSLYELCNNVYLLPQILINVYCSGFINPLESSVVKKEIQIIKQELSDQGRILLRQSGTEPYIRVMVEGKHYSKISYLANRIVSVIKGEMRSVN
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: THIE_SYNWW
Sequence: MVNSDYSLYLVTDRSLLQGRSLLEEVRKAVKGGVSMVQLREKEAGSREFYELAQTLQTELRELGVPLLINDRLDIALAVDADGLHLGQDDLPLPVARSLLGKEKIIGLSINKREEAREGEKMGADYLGVSPVFSTPTKADAPPATGLEFLASLRQEIKIPLVAIGGINKENLKMIKETGADGAAVISALMGASDIEGEARKLRQIWERN
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: FMT_VIBC3
Sequence: MSQSLRIVFAGTPDFAARHLAALLSSEHEIIAVYTQPERPAGRGKKLTASPVKTLALEHNVPVYQPENFKSDESKQQLAALNADLMVVVAYGLLLPKVVLDTPKLGCINVHGSILPRWRGAAPIQRSIWAGDSETGVTIMQMDVGLDTGDMLKIATLPIEASDTSASMYDKLAELGPQALLECLQDIAQGTAVAVKQDDGLANYAHKLSKEEARINWSDAATHIERCIRAFNPWPMSHFEVAENSIKVWQARVETRAVTQTPGTIIQADKSGIYVATGQDVLVLESLQIPGKKALPVQDILNARADWFSVGSQLS
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: NU4M_ASPAM
Sequence: MFLLLLLIPLIGIGFVTIEGNYGLSLINNIRIKSIALTTSIINLVVSLIMFILFDFSSKQFQFIEEHYQISYFDIYLGVDGLSIYFILLTTIIMPIAILCNWNSIQSKNVLSFVVIMLLLETLLLAVFLVLDVLLFYIFFESILPPLFLLIGLFGSSNKVRASFYLFLYTLLGSLFMLLSIVAMSSIMGTTDFDALSKSNFNYVTQLFLFYGIFIAFAVKTPVSFLNTWLLKAHVESPLSGSIILAGIVLKLSLYGIFRLILPLLPKASLNYTYIIYVIGVITIIYASFSTLRTIDIKELIAYSSVSHAAVYSIGAFSNTIQGIEGSIALGLAHGFVSSGLFICAGGILYDRSSTRLITYYRGMAQVMPIFSVLFFILSLGNSGTPLTLNFIGEFMSLYGVFERMPLLGVLASTSIVFSAAYTIFMYNRIVFGGSYSIYFVENIGDVTRREFIMLLVFVVLTVLFGIYPAPILDGLHYSVSSLIYSIN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: RSMH_ECOK1
Sequence: MMENYKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAKTIDDPRFSIIHGPFSALGEYVAERDLIGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTRGQSAAEWLQTAEEADIAWVLKTYGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLNVLAPGGRLSIISFHSLEDRIVKRFMRENSRGPQVPAGLPMTEEQLKKLGGRQLRALGKLMPGEEEVAENPRARSSVLRIAERTNA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_ZYMMO
Sequence: MTKETASFFTDRLAAADPDVLTAINHELNRQRKQIELIASENIVSRAVLEAQGSVFTNKYAEGYPGKRYYQGCAPSDEIETLAIERAKKLFGSEFVNVQPHSGAQANGAVLLAVAKPGDTIMGLSLDAGGHLTHGAKAAMSGKWFNAVQYAVHPETQLIDYDQVRDLALKNKPRVIIAGGSAYPRHIDFAFFRKVADEVGATFMVDMAHFAGLVAGGVHPSPVPHAHITTTTTHKTLRGPRGGMILTDDPALAKKINSAVFPGMQGGPLMHVIAAKAVAFGEALQPSFKEYAKAVVENAQALAARLKERGSDLVTGGTDTHLALVDLRPLGVTGRDADCALERAGITCNKNGIPFDPLPPVKTSGIRLGSPAATTRGFRKAEFLQVADMIADVLDALSSKGEQGDPAVETAVRQRVEALCDRFPLYPEL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMI1_SCHPO
Sequence: MSNTNFSTSRSSKSIPELPNLEALRSLWPPPSLNESGDTRSVWTTHTGEPVASSVLSTSGSNNFSSPLKRPAPESHDAPIGRRLMVDDPRLIKHGKYDFSRHCTDYGHSYEWPYFRSLRRESMLYHTSGSYPESQPPYSSYSTDAPHYYHAGSESSAYYDSRSRLHGIQPPPKRRTLSPPPRRLADPVVVGSSRYVEEEVYRRPPYTLASEVPSSASAYQAGYSSYPVRSSPQLSHEDTRHGIASSGSTRYPFVPANTRASHSPSLLEPYAHSLPSSVAPVGAYPEKSSYLLSNSSNDSASRKEKPKARASTPPPLNFSRASEHRNEKGERISMINPRVVLDENGISHRSRYFIMLCDNETAIAHAKKTSIWAVKKDSSKRISDAYKKASVYFIFVAQQTYNALGYAQVVSDLNSTELPFWSDSSHAGGVRIKWIKTCNLFSAEISEIVSHMDHGSEARDGMEMMYDEGSRLCTLINYAIMKRIGRDR
What is the function of this protein?
RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity).  Functions alone and as part of the erh1-mmi1 complex, to recruit the CCR4-NOT complex and the NURS complex to target RNAs (PubMed:26942678, PubMed:30651569, PubMed:31974447).  Suppresses the meiotic program during vegetative growth and promotes the meiotic program during mating (PubMed:31974447).  Binds to DSR (determinant of selective removal) regions in meiotic mRNA, and recruits the NURS complex to targets (PubMed:16823445, PubMed:26942678).  Recruitment of NURS complex to target mRNAs promotes mRNA decay by engagement of the nuclear exosome, and formation of heterochromatin islands at meiotic genes silenced by the exosome (PubMed:16823445, PubMed:26942678).  Recruitment of the CCR4-NOT complex to target RNAs promotes heterochromatin formation at RNAi-dependent heterochromatin domains (HOODs), including a subset of meiotic genes, lncRNAs and retrotransposons (PubMed:26942678).  Recruitment of the CCR4-NOT complex to rDNA promotes rDNA heterochromatin assembly (PubMed:26942678).  Promotes non-canonical transcription termination at meiotic genes and prevents lncRNA transcription from invading and repressing adjacent genes (PubMed:16823445, PubMed:30651569).
What are the official names of this protein?
RNA binding exosome specificity factor Mmi1, Meiotic mRNA interception protein 1, YTH domain-containing protein mmi1.
What are the subcellular locations of this protein?
Nucleus.
Protein: TP4A2_MOUSE
Sequence: MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDTNGHCCVQ
What is the function of this protein?
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis.  Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity).
What are the official names of this protein?
Protein tyrosine phosphatase type IVA 2, Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, PRL-2.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cell membrane. Early endosome. Cytoplasm.
Protein: CAN1_MOUSE
Sequence: MTEELITPVYCTGVSAQVQKKRDKELGLGRHENAIKYLGQDYETLRARCLQSGVLFQDEAFPPVSHSLGFKELGPHSSKTYGIKWKRPTELMSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQDGYAGIFHFQLWQFGEWVDVVIDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTGAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDSSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDADDYDNRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQIQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKLLDTDLDGVVTFDLFKWLQLTMFA
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.  Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'.  Cleaves and activates caspase-7 (CASP7).
What are the official names of this protein?
Calpain-1 catalytic subunit, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Micromolar-calpain, muCANP.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.
Protein: A1CF_HUMAN
Sequence: MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKVEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGQVYDPTTTYLGAPVFYAPQTYAAIPSLHFPATKGHLSNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDILPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAFVDEAKTYAAEYTLQTLGIPTDGGDGTMATAAAAATAFPGYAVPNATAPVSAAQLKQAVTLGQDLAAYTTYEVYPTFAVTARGDGYGTF
What is the function of this protein?
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA.  Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine.  The complex also protects the edited APOB mRNA from nonsense-mediated decay.
What are the official names of this protein?
APOBEC1 complementation factor, APOBEC1-stimulating protein.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum. Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.