PharMolix/UniProtQA huggingface dataset:
Protein: SDE2_SCHPO
Sequence: MECKTVFLNGDFLKNSVNVNLNRLATVETLLRHVLGDSYETVLERAYLTHQSRIVHPDIQLCKLEGKSTSAHLNLTLCTRVLGGKGGFGSQLRAAGGRMSKKRNEQENQDSCRDLDGNRLGTIRQAKELSEYLAKKPAETRAKKEAKKQKLNKVLAADSSSSRFDDHEYLEDLEQSVSNVRDAFQNSLLYRRGSTSASSFSSGSNGATTDEPAEKEARNNNSSINSWSRRMQASESSNEAEGEDSESQTSKSLYEWDDPLYGL
What is the function of this protein?
Plays a role in pre-mRNA splicing by facilitating excision of introns featuring relatively long (>21 nucleotides) spacing between the branchpoint and 3'-splice site (ss) (PubMed:36095128).  Recruits cactin to the spliceosome which may enable folding of RNA between the branchpoint and 3'-ss, to guide the splice site towards the spliceosome's catalytic center (PubMed:36095128).  Required for proper chromatin organization by assisting splicing of components involved in genomic stability and telomere organization (PubMed:21333630, PubMed:28947618, PubMed:36095128).
What are the official names of this protein?
Splicing regulator sde2, Silencing defective protein 2, Telomere maintenance protein SDE2.
What is the protein family that this protein belongs to?
Belongs to the SDE2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PALMD_HUMAN
Sequence: MEEAELVKGRLQAITDKRKIQEEISQKRLKIEEDKLKHQHLKKKALREKWLLDGISSGKEQEEMKKQNQQDQHQIQVLEQSILRLEKEIQDLEKAELQISTKEEAILKKLKSIERTTEDIIRSVKVEREERAEESIEDIYANIPDLPKSYIPSRLRKEINEEKEDDEQNRKALYAMEIKVEKDLKTGESTVLSSIPLPSDDFKGTGIKVYDDGQKSVYAVSSNHSAAYNGTDGLAPVEVEELLRQASERNSKSPTEYHEPVYANPFYRPTTPQRETVTPGPNFQERIKIKTNGLGIGVNESIHNMGNGLSEERGNNFNHISPIPPVPHPRSVIQQAEEKLHTPQKRLMTPWEESNVMQDKDAPSPKPRLSPRETIFGKSEHQNSSPTCQEDEEDVRYNIVHSLPPDINDTEPVTMIFMGYQQAEDSEEDKKFLTGYDGIIHAELVVIDDEEEEDEGEAEKPSYHPIAPHSQVYQPAKPTPLPRKRSEASPHENTNHKSPHKNSISLKEQEESLGSPVHHSPFDAQTTGDGTEDPSLTALRMRMAKLGKKVI
What are the official names of this protein?
Palmdelphin, Paralemmin-like protein.
What is the protein family that this protein belongs to?
Belongs to the paralemmin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine.
Protein: CAD12_HUMAN
Sequence: MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEEESYNPDKVT
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
What are the official names of this protein?
Cadherin-12, Brain cadherin, BR-cadherin, Neural type cadherin 2, N-cadherin 2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: AROA_STAAS
Sequence: MVNEQIIDISGPLKGEIEVPGDKSMTHRAIMLASLAEGVSTIYKPLLGEDCRRTMDIFRLLGVEIKEDDEKLVVTSPGYQSFNTPHQVLYTGNSGTTTRLLAGLLSGLGIESVLSGDVSIGKRPMDRVLRPLKLMDANIEGIEDNYTPLIIKPSVIKGINYQMEVASAQVKSAILFASLFSKEPTIIKELDVSRNHTETMFKHFNIPIEAEGLSINTTPEAIRYIKPADFHVPGDISSAAFFIVAALITPGSDVTIHNVGINPTRSGIIDIVEKMGGNIQLFNQTTGAEPTASIRIQYTPMLQPITIEGELVPKAIDELPVIALLCTQAVGTSTIKDAEELKVKETNRIDTTADMLNLLGFELQPTNDGLIIHPSEFKTNATVDSLTDHRIGMMLAVASLLSSEPVKIKQFDAVNVSFPGFLPKLKLLENEG
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_LISMO
Sequence: MVKQIMIQGTASDAGKSVLVAGLCRLFKNKGKRVVPFKSQNMSLNSFITATGDEMGRAQVFQAEAAGVFPDVRMNPVLLKPTNDRQSQVIFMGAILDNMDAVTYHDFKQTLIPKIQAVYQSLADENDIIVLEGAGSPAEINLNDRDIVNMGMAKMVDAPVVLVADIDKGGVFASIYGTIMLLNEEERARIKGVIINKFRGDVALLQPGIDMIEELTNVPVIGVIPYANLQLEEEDSVSLNGKNYAPDSNALLDIAIICLPRISNFTDFHSLEIQPEISLRYIRNLADFGKPDLVIIPGSKNTLEDMAFLEESGLKKAIQNFAENAGKVIGICGGYQMLGQKMLDPDQVESKQLEIAGLGLLDTETIFLDQKRTTQITGVTHSGEAVEGYEIHMGETKRGESTSPFCKIKAVNGNEETHQDGAISANKNIIGTYIHGIFDNDVFLGNLFDELLTRKNQSIYPHEIINLKEHKEQEYDKLAALLEANIQMDQLEKIMKGEKICVSTQKPAIKE
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: GATY_ECO27
Sequence: MYVVSTKQMLNNARRGGYAVPAFNIHNLETMQVVVETAASMHAPVIIAGTPGTFTHAGTENLMALVSAMAKQYHHPLAIHLDHHTKFDDIAQKVRSGVRSVMIDVSHLPFAQNISRVKEVVDFCHRFDVSVEAELGQLGGQEDDVQVNEADAFYTNPVQAREFAEATGIDSLAVAIGTAHGMYARAPALDFSRLENIRQWVNLPLVLHGASGLSTKDIQQTIKLGICKINVATELKNAFSQALKNYLTEHPEATDPRDYLQSAKSAMRDVVSKVIADCGCEGRA
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires GatZ subunit for full activity and stability.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.
Protein: COQ6_YEAST
Sequence: MFFSKVMLTRRILVRGLATAKSSAPKLTDVLIVGGGPAGLTLAASIKNSPQLKDLKTTLVDMVDLKDKLSDFYNSPPDYFTNRIVSVTPRSIHFLENNAGATLMHDRIQSYDGLYVTDGCSKATLDLARDSMLCMIEIINIQASLYNRISQYDSKKDSIDIIDNTKVVNIKHSDPNDPLSWPLVTLSNGEVYKTRLLVGADGFNSPTRRFSQIPSRGWMYNAYGVVASMKLEYPPFKLRGWQRFLPTGPIAHLPMPENNATLVWSSSERLSRLLLSLPPESFTALINAAFVLEDADMNYYYRTLEDGSMDTDKLIEDIKFRTEEIYATLKDESDIDEIYPPRVVSIIDKTRARFPLKLTHADRYCTDRVALVGDAAHTTHPLAGQGLNMGQTDVHGLVYALEKAMERGLDIGSSLSLEPFWAERYPSNNVLLGMADKLFKLYHTNFPPVVALRTFGLNLTNKIGPVKNMIIDTLGGNEK
What is the function of this protein?
FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis.  Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB).  The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via ferredoxin (YAH1) and ferredoxin reductase (ARH1) to COQ6 (PubMed:21944752).  Can also convert 3-hexaprenyl-4-aminobenzoic acid (HAB), a COQ2-prenylated pABA, to DHHB in a two step process.  HAB is first hydroxylated at C5 to yield 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) which is further deaminated at C4 by COQ6 to produce DHHB (PubMed:26260787).
What are the official names of this protein?
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial, Ubiquinone C4-deaminase.
What is the protein family that this protein belongs to?
Belongs to the UbiH/COQ6 family.
Protein: PDXT_CUTAK
Sequence: MAPLVGVVALQGGFAEHIEVLESLGANTRRVRRSADLQGLDGIVLPGGESTVIDKLMRSFSLAEPLKDAVRRGLPVLATCAGLVVLATDLEDAAKGQHTLSLLDVTVRRNAFGSQLDSFEGTLDIDGVGDGVSATFIRAPVITRVGPGVEVIAQLPDEAGNVSGAIVGVRQRNVLALSFHPEETDDDRVHRTWLRQVSEEV
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: RL11_MESM1
Sequence: MAKKKEVVRVAKLQFNAGQAKPGPELAGLGIVMPEFTKQFNDATRERSGEPVPVQIIVYKDKSFDFKLFTAPTSFMLKKAAGIKSGSANSKTTIVATIKKSQLEDIAKYKMPDLNTKNLEEAMHTIAGTARNMGILVEGYDDIVKAREEAKLAAKEAASAAAFEAKLESDAAQLLAENKQSAEVEVIKEKDKGNKDE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: HFLX_BACSU
Sequence: MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKVLTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVKMIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGETKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFNRLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEEVKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAGRDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFYFNEENEQYDISGYVQEEQSIIGELKKYM
What is the function of this protein?
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
What are the official names of this protein?
GTPase HflX, GTP-binding protein HflX.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=May associate with membranes.
Protein: SRPRA_MOUSE
Sequence: MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKTKEKAKNNKKRGAKKEGSDGTLATSKTAPAEKSGLSAGPENGELSKEELIRRKREEFIQKHGKGLDKSSKSTKSDTPKEKGKKAPRVWELGGCANKEVLDYSTPTTNGTPEAALSEDINLIRGTGPGGQLQDLDCSSSDDEGATQNTKPSATKGTLGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLTALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA
What is the function of this protein?
Component of the SRP (signal recognition particle) receptor (By similarity).  Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).  Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (By similarity).  SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
What are the official names of this protein?
Signal recognition particle receptor subunit alpha, SR-alpha, Docking protein alpha, DP-alpha.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.
Protein: SAHH_MYXXD
Sequence: MTAATKSLKQDYAIADLSLADWGRKEIRIAESEMPALMAIREEYAKTQPLKGARVTGSLHMTIQTAVLVETLQALGAEVRWASCNIFSTQDHAAAALVQAGTPVFAHKGESLKEYWDFTHRIFDFGPAGSDHEGPNMILDDGGDATLLMHLGKRAEKDASVLANPQSEEERELYAAIKAKLAEDATWYTRKSAKILGVTEETTTGVHRLQEMSAKGTLLFRAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMVAGKIAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAADKADIFVTATGNKGVITHDHMAKMKDQAIVCNIGHFDNEIEVASLEKYKWEEIKPQVDHIIFPDNKRIILLAKGRLVNLGCGTGHPSYVMSSSFANQTIAQIELYSHSANYEVGKVYVLPKHLDEKVARLQLKKLNAQLTELSQEQADYIGVKTSGPYKPDTYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRRF1_MOUSE
Sequence: MTSPEGAQNKEIDCLSPEAQRLAEARLAAKRAARAEAREIRMKELERQQKEVEERPDKDFAEKGSRNMPSLSAATLASLGGTSSRRGSGDTSISMDTEASIREIKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESQRQYEEKNKEFEREKHAHSILQFQFAEVKEALRQREEMLEKHGIILNSEIATNGETSDTVNDVGYQAPTKITKEELNALKSAGEGTLGKAKEVEVKKEIVEKVGQRETLQNSEQEQPKPNTGKDCVDRGVSHPGEKAENQRPAEDSALSPGPLAGAKCEQQVQSQDQENTSDLKNSEQIESHKVTNKSDSRASNSPEQSSCLEGLDSEVPGPTEDLKTDLGKGSFEPCPDYILGQTAEIDKVTCTDSRGTGGNQREDEVQAGDTTVEDQVGTVASGPAKQSKGTENHGESCLKDGLGQSSERELTQEVAEPEEAIVQIPQAGGENTITKADDAEGRDEKPIQAEAQASPGAPINQSGHQDTTGPGSTDAQRTPPHAKERKKQGKSEQQAEALDSPQKKTKNKKKKNKKKKAATPAETCRDANEELNCQDPDVGDMEEEERLQVTDKKQASGSPEQKIRAGSREPVEDPQSGSSGKQNKVEEDGPTEGPTDILDQNSPQCEDREISPVGEKGPQCDTSQIGSEEGHVTSQHGGQAVENHNLDNSDLSGQLEGFNSESGGQAREEVGNSKSKEDCTMS
What is the function of this protein?
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA.  May control smooth muscle cells proliferation following artery injury through PDGFA repression.  May also bind double-stranded RNA (By similarity).  Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity).
What are the official names of this protein?
Leucine-rich repeat flightless-interacting protein 1, LRR FLII-interacting protein 1, FLI-LRR-associated protein 1, Flap-1, H186 FLAP.
What is the protein family that this protein belongs to?
Belongs to the LRRFIP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RL6_CALBD
Sequence: MSRIGRKPIDIPSGVDVKIDGNVITVKGPKGTLTREIHPEMIVKIENNQIIVQRPSDERFHKALHGLTRTLIANMVEGVTKGYEKVLEVVGIGYRAQKQGKKLVLNVGYSHPVEIEEPAGITIEVPDQNRIVVKGIDKQQVGNFAANIRKVREPDPYLGKGIKYADEVLRLKEGKAGKGGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ATG9_SCLS1
Sequence: MASNLISRLLPSNTQGRSIYDSLRAHDEASGSDMDVEERAAMAIDEENLRFKDDELGNPADVISGESVTESTAFLSDQQQTPQKQGYNRKGKGKGRSHNLAESPRLLEEDSDDDVPASLLIEGNNRHADPETPNHIRARQTALPKRAPAVPGPSAQQIKEERDRAHWEMTQEQQKLHEDGGNRATGVPHTPQSIPQNTGFYLTGSPKDKAMYRWVNVTNLDNFIGDLYAYFEGAGIWCIVLAKVIDILTLVFVAVFTTFLTQCVDYKKIYRGDARSLEYALVPQCTKKISGMSNVAIWLVCLFVLYRVYQLLTDLPRLMKMRDFFTYLLEIQDSNMQTVSFQDVIARLMALRDANPMTVERISPDNRKFVLGTQSKQRLDAHDIANRLMRKENYLIALFNKEILDLTLPLPFLQGRQLFSKTLQWNLEWCILDFVFNDYGQVRQLVLKDSHRRELSDGLRNRFLFAGLMNVICAPVIVIYVVIVYFFKYFNQYHKNPAALGSRGYTPLAEWKFREFNELHHLFNKRLNMSYPFASRYLNQFPNVKTAHMAKFITFMAGAVVSVLVVATVWDSEVLAGFDITSERPVLFYIGVFGSLWAITNGMIPEENEVFDPEYALRQVIEYTHYMPNHWQDRLHSDEVKREFSTLYQLKLMIFIEEVFSIIITPFLLWFSLPKCADQIIDFFREFTVHVDGVGYVCSFAVFDFKKGDGRAPTQGKAKSDMREDYYSTKHGKMAASYYNFLDNYLLNPKTGVPGHNPPGLRQQFYPPPAFPGLISSPTSGADLQSSRMGRSDVRPMNRAPYVPQQAVRTPRFPSNTTATGSPMASILLDPRHQPPSSELGARSVRRSSRSRYQARRGNNIIEDPMEDENGPGRPVAQPGRSYAVDDTVANLGESTWEVSPAKADADGQDEEEDGDGTGGAGVLGLVYQFQKAQTNGRPGVSIW
What is the function of this protein?
Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation.  Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome.  Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through atg2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.  Required for mitophagy.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.
What are the official names of this protein?
Autophagy-related protein 9.
What is the protein family that this protein belongs to?
Belongs to the ATG9 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: EFTS_PSYA2
Sequence: MSEVKVSAKMVKELRDRTGLGMMECKKALEESNGDVETAIDNLRKSGQAKAAKKAGNIAADGAIIIAQGESKAFLLEVNCQTDFVAKDENFTAFAETVANIALENNVTDVAAIAELPYGNDQTVEEARVSLVQKIGENIQIRRVEVLEGANIAAYRHGLRIGVVVSYEGGSAETGKNLAMHIAAFNPVAIDDEDVAADLLAREKDIIEAKARESGKPDNIVEKMIEGGLRKYLEEVTLLRQSYVMDNEKKVGDVLKAEGVKVLGFKRLEVGEGIEKKQEDFAAEVAATQALANK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GVPJ1_HALSA
Sequence: MSDPKPTRSQGDLAEMLEMLLDKGVVVNADIAVSVGDTELLGIELRAAIASFETAAEYGLEFPTGTDMERVESAANISPDQSDPASETQSETESTNPLSDDSTPTASTSAEETK
What is the function of this protein?
Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms.  They allow the positioning of the organism at the favorable depth for growth.  This protein could be important for the shape determination of the gas vesicle.
What are the official names of this protein?
Gas vesicle protein GvpJ 1.
What is the protein family that this protein belongs to?
Belongs to the gas vesicle protein type A family.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: NODI_BURTA
Sequence: MSVAPIDFQQVEKRYDDKLVVDGLSFHVQPGECFGLLGPNGAGKTTALKMLLGITHPDAGSISLCGEPVPSRARHARRRVGVVPQFDNLDPDFTVRENLLVFARYFGLAAHEARALVPPLLEFAKLENKADAKVGELSGGMKRRLTLARALVNNPDVLVLDEPTTGLDPQARHLMWERLRSLLVRGKTILLTTHFMEEAERLCHRLCVIEEGRKIAEGAPRTLIESEIGCDVIEIYGPDPAQLREELAPFAERTEISGETLFCYVDDPEPVNARLKGRAGLRYLHRPANLEDVFLRLTGREMQD
What is the function of this protein?
Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction.  Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide.  This subunit is responsible for energy coupling to the transport system.
What are the official names of this protein?
Nod factor export ATP-binding protein I, Nodulation ATP-binding protein I.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipooligosaccharide exporter (TC 3.A.1.102) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PSAL_PROMS
Sequence: MSDFQKSFSESTSSIKFDEKYIDNSVQPNDIGVAEQWAVKTVADPCVGNLATPVNSGYFTKAFINNLPFYREGISPNFRGLETGAAFGYLLYGPFTMTGPLRNSEFALTAGLLAAIGAVHILTALLVLYNAPGKAPNVQPPDATVNNPPKDLFTRAGWADFTSGFWLGGCGGSVFAWLLVGTLHLDTIMPIIKNIWTAG
What are the official names of this protein?
Photosystem I reaction center subunit XI, PSI subunit V, PSI-L.
What is the protein family that this protein belongs to?
Belongs to the PsaL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: LCYB_SYNE7
Sequence: MFDALVIGSGPAGLAIAAELAQRGLKVQGLSPVDPFHPWENTYGIWGPELDSLGLEHLFGHRWSNCVSYFGEAPVQHQYNYGLFDRAQLQQHWLRQCEQGGLQWQLGKAAAIAHDSHHSCVTTAAGQELQARLVVDTTGHQAAFIQRPHSDAIAYQAAYGIIGQFSQPPIEPHQFVLMDYRSDHLSPEERQLPPTFLYAMDLGNDVYFVEETSLAACPAIPYDRLKQRLYQRLATRGVTVQVIQHEEYCLFPMNLPLPDLTQSVVGFGGAASMVHPASGYMVGALLRRAPDLANAIAAGLNASSSLTTAELATQAWRGLWPTEKIRKHYIYQFGLEKLMRFSEAQLNHHFQTFFGLPKEQWYGFLTNTLSLPELIQAMLRLFAQAPNDVRWGLMEQQGRELQLFWQAIAAR
What is the function of this protein?
Catalyzes the double cyclization reaction which converts lycopene to beta-carotene (PubMed:7919981, PubMed:8344419).  It also converts neurosporene to the monocyclic beta-zeacarotene but does not cyclize zeta-carotene (PubMed:7919981).
What are the official names of this protein?
Lycopene beta cyclase, Lycopene cyclase.
What is the protein family that this protein belongs to?
Belongs to the lycopene cyclase family.
Protein: ACT1_PLAFO
Sequence: MGEEVVQALVVDNGSGNVKAGVAGDDAPRSVFPSIVGRPKNPGIMVGMEEKDAFVGDEAQTKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRAAPEEHPVLLTEAPLNPKGNRERMTQIMFESFNVPAMYVAIQAVLSLYSSGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRLDLAGRDLTEYLMKILHERGYGFSTSAEKEIVRDIKEKLCYIALNFDEEMKTSEQSSDIEKSYELPDGNIITVGNERFRCPEALFQPSFLGKEAAGIHTTTFNSIKKCDVDIRKDLYGNIVLSGGTTMYEGTGERLTRDITTLAPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQQMWITKEEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm.  Polymerizes into shorter and less stable actin filaments compared to ACT2/actin-2; this is thought to facilitate gliding motility and host cell invasion.  Has ATPase activity.  ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi.  ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin.  Plays an essential role during the asexual blood stage.  At the segmented schizont stage, required for apicoplast migration and segregation into individual daughter merozoites.  Also, required for the separation of daughter merozoites in the final stages of cytokinesis.  Essential for merozoite invasion of, but not adhesion to or reorientation towards, host erythrocytes.
What are the official names of this protein?
Actin-1, Actin I, pf-actin I.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: FTSH1_THERP
Sequence: MSDNKWLRNGFVWMILIIAAIAVWVTFVQGGRGGATITTQEMAADIKAGKVERLVMTSGSDEIQVQYIGTNEVRTLRLPPNVDIFELLKTFGIDPQQVDIQTHRASQWGNVLGTLTFLLPTLFLIGVIIFMMRQAQGTNNQALSFGKSRARVFTSNRPTVTFDDVAGVDEAKEELQEIVEFLKYPEKFAALGARIPRGVLLVGPPGTGKTLLSRAVAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFDQAKRNAPCIVFIDEIDAVGRQRGAGLGGSHDEREQTLNQILVEMDGFDSSTNVIVIAATNRPDVLDPALLRPGRFDRQVVLDRPDLHGRLAILKVHTRGKPLESDVDLEDLARQTPGFSGADLENLVNEAAILAARRNKKTIGRRELYEAIDRVVAGPERKSRRISEREKLMTAYHEAGHALVARMLPHADPVHKVSIVARGMMGGYTRVLPEEDRFFWTKKQFEAQLAVFMAGLVAEELVFQEVSTGAANDIERATTLARRMVTEFGMSERLGPLAFGRKEELVFLGREIAEQRNYSDQVAYEIDQEVRRLIDQAYQTAKQILLDHMDKLEKIATLLVEKETLDGHEIEALFDEPRPRPELVGPPLTRPAALIATPETARPDSPSEARPAAPVPHIKPQPAS
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.