PharMolix/UniProtQA huggingface dataset:
Protein: PHAC_CUPNH
Sequence: MATGKGAAASTQEGKSQPFKVTPGPFDPATWLEWSRQWQGTEGNGHAAASGIPGLDALAGVKIAPAQLGDIQQRYMKDFSALWQAMAEGKAEATGPLHDRRFAGDAWRTNLPYRFAAAFYLLNARALTELADAVEADAKTRQRIRFAISQWVDAMSPANFLATNPEAQRLLIESGGESLRAGVRNMMEDLTRGKISQTDESAFEVGRNVAVTEGAVVFENEYFQLLQYKPLTDKVHARPLLMVPPCINKYYILDLQPESSLVRHVVEQGHTVFLVSWRNPDASMAGSTWDDYIEHAAIRAIEVARDISGQDKINVLGFCVGGTIVSTALAVLAARGEHPAASVTLLTTLLDFADTGILDVFVDEGHVQLREATLGGGAGAPCALLRGLELANTFSFLRPNDLVWNYVVDNYLKGNTPVPFDLLFWNGDATNLPGPWYCWYLRHTYLQNELKVPGKLTVCGVPVDLASIDVPTYIYGSREDHIVPWTAAYASTALLANKLRFVLGASGHIAGVINPPAKNKRSHWTNDALPESPQQWLAGAIEHHGSWWPDWTAWLAGQAGAKRAAPANYGNARYRAIEPAPGRYVKAKA
What is the function of this protein?
Polymerizes (R)-3-hydroxybutyryl-CoA to create polyhydroxybutyrate (PHB) which consists of thousands of hydroxybutyrate molecules linked end to end.  PHB serves as an intracellular energy reserve material when cells grow under conditions of nutrient limitation.
What are the official names of this protein?
Poly(3-hydroxyalkanoate) polymerase subunit PhaC, PHA polymerase, PHB synthase subunit PhaC, Poly(3-hydroxybutyrate) polymerase subunit PhaC, PHB polymerase, Poly-beta-hydroxybutyrate polymerase, Polyhydroxyalkanoate synthase subunit PhaC, PHA synthase.
What is the protein family that this protein belongs to?
Belongs to the PHA/PHB synthase family. Type I PhaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_FRATN
Sequence: MISFIKGVLIEKDPTALLIDVNGIGYEVFVPMTTFYTLGDIDSQVSLYTHFVVREDAQQLYGFKSKVDKKVFQELIKVNGIGARTAIAILSGMDSKTLLHCIENKDYALLATVPGIGKKTAERLVVEIYDKLLKMANEIYAQTSGTTTTSQDSQAQQAPTSAVLANSIFNESVDALLALGYKQKDAEKMSRSAMGDATTAAEVIRKALQGSIRSKR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: G137B_DANRE
Sequence: MQKDSLPTLSPAVPPYVMLGLTVAYTIFYCLLFVFVYVQLWLVLRYRHKRFSYQTVFLFLCLLWAALRALLFSFYFKNCVTANTLGPFCFWLLYCFPVCLQFFTLSLMNLYFAQVIFKAKSKYSPELQKYRLPLYLLFLSISLLFLLVNLTCALLVKINRANTETVVLVRVTVNDSLFVLCAVSLSLCLYRIAKMSLANIYLEAKGTSVCQVTLIGVTVVLLYSSRACYNLVVLALTKIKSINSFDYDWYNVSDQADLKSTLGDAGYVVFGVILFVWELLPTSLVVYFFRVRKPTLDRSASVIPGHMFSSRAYFFDNPRRYDSDDDLAWSIIPQNIQASFTSDSYDWSCRNNSFTAYTEAEESHLAPEELNPY
What is the function of this protein?
Acts also as a negative regulator of osteoclast activity (PubMed:31173907).  May be involved in interleukin-4-induced M2 macrophage polarization (By similarity).
What are the official names of this protein?
G protein-coupled receptor 137Ba.
What is the protein family that this protein belongs to?
Belongs to the GPR137 family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: RBCR_ACIFR
Sequence: MSIRHATLHQLKIFAAVARHMSFARAAEELHLTPPALSIQVRQLAEAVGQPLFDQIGKKIYLTAAGEALTSACHDILDRLEYFTQEIAALQGLEKGSLKVATLSTTKYFIPRMLGGFCTEHPGVATVLFIGNREVLLERLARNQDDLYILGQPPEHMNVVAEAFADNPLVVVARLDHPLTQEKDIEPSRLRDVPFILREPGSGTRLAAEKFFEQHGVILKTRMEFGSNEAVKQSVAGGLGITVLSASTIRAELASGKLAILDVRGFPLERKWYAVYPAGKRISPRTKAFMEYLFAASADGENGPSLPKP
What is the function of this protein?
Trans-acting transcriptional regulator of RuBisCO genes (rbcL1S1) expression.
What are the official names of this protein?
RuBisCO operon transcriptional regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: PGK_HERA2
Sequence: MNKQTIRDVAWSGKRALVRVDFNVPLDQARKVTDDTRIRAALPTINYLLEQGASVILMSHLGRPKKKVAEEFRLKPVADHLQSLLDAPVNYIQTTTGAEAEAAAQALQAGQVLLLENTRFDPREESNDPAMAEELAKLGDIYVNDAFGAAHRAHASTEGLAKFLPAVAGFLMEAELAALGKALDDPQRPFVTIIGGAKISDKIGVIENLLGKVDSLLIGGGMANTFLLAQNKAVGASLVEADSVAEAGRLIDEAQGRGVKLLLPSDVVVADAFSAEANTQVLSIDDVPDGWRILDIGPETRQTYSQVVSEAKTVIWNGPMGVFELEPFAAGTRAVAQALADSSAITIIGGGDSVAAIEQMGLAEKMSHISTGGGASLELLEGKVLPGIAALNDK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G1L8_ORYSJ
Sequence: MEGGGGGADGQAQPVAQAPPAMQPMQQLSRYESQKRRDWNTFLQYLKNHRPPLTLARCSGAHVIEFLKYLDQFGKTKVHASGCAYYGQPSPPAPCPCPLRQAWGSLDALIGRLRAAYEESGHAPESNPFAARAVRIYLREVRDAQAKARGIPYEKKKRKRTQQQQPPPPPPPPPQHQPGAAAGEASSSSSAAAAAVAAEGSGSSAAAAAATSQTGGGGGGSTTTTTASAAAPTTATRV
What is the function of this protein?
Probable transcription regulator that acts as a developmental regulator by promoting cell growth in response to light.
What are the official names of this protein?
Protein G1-like8.
What is the protein family that this protein belongs to?
Belongs to the plant homeotic and developmental regulators ALOG protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FBXL2_MOUSE
Sequence: MVFSNSDDGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRVDLFNFQTDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNHCHELVSLNLQSCSRITDDGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQVLEAARCSHLTDAGFTLLARNCHELEKMDLEECVLITDSTLVQLSIHCPKLQALSLSHCELITDEGILHLSSSTCGHERLRVLELDNCLLVTDASLEHLENCRGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPPAVAGSGHRLCRCCVIL
What is the function of this protein?
Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21343341, PubMed:23542741).  Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin (By similarity).  This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin (By similarity).  Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (By similarity).  SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (By similarity).  PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (PubMed:21343341).  The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (PubMed:23542741).  The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (By similarity).
What are the official names of this protein?
F-box/LRR-repeat protein 2, F-box and leucine-rich repeat protein 2.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor.
Protein: FER9_METJA
Sequence: MVMKKIIMTNFNCDNCGDCVKACMEKNKVGRIAIMEKDGKYIPIVCQHCASAPCKEVCPVSAIEHKDGYVYLNEDVCIGCGLCALACPFGAILMEDKAYKCILCNGDEPACVKACSKRCLELVDVNELIFAKRDKSLDLFSKMSLPTQKSDNSLISKITIDAKVKP
What are the official names of this protein?
Uncharacterized ferredoxin MJ0265.
Protein: RSMH_HAEI8
Sequence: MNSENSFSSSEHITVLLHEAVNGLALKENGIYIDGTFGRGGHSRFILSQLSSNGRLIAVDRDPRAIAEAHKIQDLRFQIEHNSFSHIPEICDKLNLVGKIDGILLDLGVSSPQLDEAERGFSFMKDGPLDMRMDTTQGLSAEEWLKQVSIEDLTWVLKTFGEERFAKRIATAIVDFNKSAVKNSTEFLSRTSQLAELISQAVPFKDKHKHPATRSFQAIRIFINSELDELESLLNSALDMLAPEGRLSIISFHSLEDRMVKHFMKKQSKGEDIPKGLPLREDQIQRNQKLRIIGKAIQPSDAEIQANPRSRSAILRVAERI
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_LISMO
Sequence: MRCPTCQYNGTRVVDSRPADDGNSIRRRRECEKCGFRFTTFEKVEESPLIVVKKDGAREEFAREKVRRGLIRACEKRPVSAEQIEEIVNEVERELRNIGDSEIASDLIGEKVMNKLANLDEVAYVRFASVYRQFKDISVFVEELKDLMEKNKDR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PER22_ORYSJ
Sequence: MASATNSSLSLMLLVAAAMASVASAQLSATFYDTSCPNALSTIKSVITAAVNSEARMGASLLRLHFHDCFVQGCDASVLLSGQEQNAGPNVGSLRGFSVIDNAKARVEAICNQTVSCADILAVAARDSVVALGGPSWTVLLGRRDSTTASEALANTDLPAPSSSLAELIGNFSRKGLDATDMVALSGAHTIGQAQCQNFRDRIYNETNIDSAFATQRQANCPRPTGSGDSNLAPLDTTTPNAFDNAYYSNLLSNKGLLHSDQVLFNGGSADNTVRNFASNAAAFSSAFTTAMVKMGNISPLTGTQGQIRLSCSKVNS
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 22.3.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TSAC_ECO57
Sequence: MNNNLQGDAIAAAIDVLNEERVIAYPTEAVFGVGCDPDSETAVMRLLELKQRPVDKGLILIAANYEQLKPYIDDTMLTDVQRETIFSRWPGPVTFVFPAPATTPRWLTGRFDSLAVRVTDHPLVVALCQAYGKPLVSTSANLSGLPPCRTVDEVRAQFGAAFPVVPGETGGRLNPSEIRDALTGELFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFA_NEIMB
Sequence: MTLTKAELADILVDKVSNVTKNDAKEIVELFFEEIRSTLASGEEIKISGFGNFQLRDKPQRPGRNPKTGEEVPITARRVVTFHASQKLKSMVEHYYDKQR
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RRFM_CAEEL
Sequence: MIRLAVIRLAQGASRAQFLQKQAQIFTSAVVNAKKKADNKKKNPPAVFSNLEENAVVQETIKEIQRVEGLLVEELTRHFSLKVDIRQYEDVMVKLENGKDKPLSMIARVTLKSPLMIMINFQDNPSAIKAAKLAIQKSTLNVTPQQEGAVLYVNVPPMSKERREKMASDAKGRILNEYKKAINEIYSKSDKKSSNEFSTRPDEAKKTREALLNMKHAAEQRGGLLIEERRKQLLKQVV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).
What are the official names of this protein?
Ribosome-recycling factor, mitochondrial, RRF, Ribosome-releasing factor, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS16_TREPA
Sequence: MSLRIRLKKLGSKKRPYYRIVVQDAREPRDGRAIEELGIYQPIAPKGTEVSFRLDRARFWLERGAQPSDTVRRLLQSRRGSVLNAVASDERRVASSQQAADLAHVESVSCAAPIPSSPGGQGV
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: ODP2_MESAU
Sequence: VPLPSLSPTMQAGTIARDVPLGAPLCIIVEKGRVFVSPLAKGIDLTQVKGTGPEGDIDSFVPSKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIASDVVSLASKEGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLEKPITMLL
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
What are the official names of this protein?
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, Pyruvate dehydrogenase complex component E2, PDC-E2, PDCE2.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CHIP_MOUSE
Sequence: MKGKEEKEGGARLGTGGGGSPDKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQPEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQESELHSYLTRLIAAERERELEECQRNHEGHEDDGHIRAQQACIEAKHDKYMADMDELFSQVDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMKEVIDAFISENGWVEDY
What is the function of this protein?
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:11435423, PubMed:21855799).  Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:11435423, PubMed:21855799).  Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (By similarity).  Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (By similarity).  Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (By similarity).  Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (By similarity).  Mediates polyubiquitination of CYP3A4 (By similarity).  Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (By similarity).  Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation.  Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).  Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303).  Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (By similarity).  Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (By similarity).  May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity).  Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase CHIP, Carboxy terminus of Hsp70-interacting protein, RING-type E3 ubiquitin transferase CHIP, STIP1 homology and U box-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg).
Protein: YJS1_YEAST
Sequence: MEIFKEEEEEAFSAIEGIIYACEVYDPVPRHLHKSKTKIINAAKLIIETHLSYYTILNNISDIQAYLSTWLRDLGTTGPYQTILSESISLMFDRTVSIFRKCTIEGGFPHLIARLYLRLKSYQKLLNDAGLKNFFSSYDYAFGVAYNLVNCSEYRYDEVHYISNGTYSLVASMKIDPAEVIKREHFRLTIPKFNISNILIEIFHLLDGLAFFKVNPDSLSISTASAETIFRSISEGNHQVLELGRSLMFPLLRTGDFEICRIDDAGAVITFTEAKDVKLEIISLDEVSWVMQWKSCLQNYERRAANDSSFIKTHLQFKKANNFNEDNNGLGLIVDRNIPTDDFTLASTNRQSPPPSNTGCSLHRSKPLHIPLSSVIREDFYDSSLNERISKDGDSSCESFSGAESILSDYDFHDNEFFNNQSPHYFSEHIDNNSREVVITDENTIISLENTQVSRWSNYSWQKISPHQLQVSIIQLRMGNFIVAYDSDYNLHQFKIRLCDDIKCIQSTEQDIQIRVPLGAIMCSVTGILNIRTKDADKLLRVLSFYTTDHTEAVSHSNNQDATASPLSSVSSAMDLKHSLQKCSSTIMPQELTQDVIGSKSDLISNIRQKI
What are the official names of this protein?
UPF0508 protein YJL181W.
What is the protein family that this protein belongs to?
Belongs to the UPF0508 family.
Protein: NLTPX_ORYSI
Sequence: MMRRLAVLVLAVAMVAACGGGVVGVAGASCNAGQLTVCAGAIAGGARPTAACCSSLRAQQGCFCQFAKDPRYGRYVNSPNARKAVSSCGIALPTCH
What is the function of this protein?
Transfer lipids across membranes.  May play a role in plant defense or in the biosynthesis of cuticle layers.
What are the official names of this protein?
Non-specific lipid-transfer protein 2, nsLTP2, 7 kDa lipid transfer protein.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family. B11E subfamily.
Protein: PXPA_SALTI
Sequence: MNIDLNADLGEGCASDSELLTLVSSANIACGFHAGDAQTMLTCVREALKNGVAIGAHPSFPDRDNFGRTAMVLPPETVYAQTLYQIGALGAIVQAQGGVMRHVKPHGMLYNQAAKDPHLAQAIAKAVHDYDPSLILVGLAGSELIRAGERHRLVTRQEVFADRGYQADGSLVPRMQPGALIHDEEQALAQTLDMVQAGRVKSVTGVWTTVTAQTVCIHGDGEYALAFARRLRAAFNARNVHVIA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: AR277_ARTOA
Sequence: MAPCIPKKYTAGQNPVTKFEGAFVVTKMDPPEGRCFLFHTVINVNHHRVKALEKSGKKPPKHFHPNQYEYFKVISGQLTVEINDVEHILTPEDGEVTLEPGPHHRLWGTPGQKNDKVVFLISASTNARSYQLDQAFFENWYGYQEDMMMRGTAPDLIQVCCMFEAGDSYLSPPWWVPFRHFFGYWLTVILGYYIGSLLGYQPFFPEWTTDWDAACDKMASSLLQKKFAIRELQDVVKKNFDANGDPLPAKKLL
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of sesquiterpenyl epoxy-cyclohexenoids (SECs) such as anthrobotrisins and arthrosporols, metabolites that possess a novel hybrid carbon skeleton consisting of a polyketide-derived epoxycyclohexenol combined with a terpenoid-derived monocyclic sesquiterpenol substructure (PKS-PTS hybrid) (PubMed:33823587).  The SEC pathway plays an important role for fungal soil colonization via decreasing fungal nematode-capturing ability (PubMed:33823587).  Within the pathway, the oxidoreductase AOL_s00215g277 seems to play a role in the farnesylation step of toluquinol to produce farnesyl hydroquinone, the hybrid precursor for biosynthesis of SECs (PubMed:33823587).  The pathway begins with the biosynthesis of 6-methylsalicylic acid (6-MSA), the first precursor of the polyketide-derived epoxycyclohexenol in arthrosporols, by the polyketide synthase (PKS) AOL_s00215g283 via condensation of 1 acetate and 3 malonate units.  The 6-methylsalicylic acid decarboxylase AOL_s00215g281 then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol.  The cytochrome P450 monooxygenase AOL_s00215g282 further oxidizes m-cresol to yield toluquinol.  With the assistance of the oxidoreductase AOL_s00215g277, the polyprenyl transferase AOL_s00215g276 catalyzes the farnesylation of toluquinol to produce farnesyl hydroquinone, the hybrid precursor for biosynthesis of SECs.  Farnesyl hydroquinone undergoes epoxidation and then subsequent dehydrogenation to form farnesyl epoxy-quinone, the first and simplest SEC.  The cytochrome P450 monooxygenase AOL_s00215g278 and the FAD-dependent monooxygenase AOL_s00215g279 might be involved in the oxygenation of the phenol moiety, most likely in the epoxy formation.  The cytochrome P450 monooxygenases AOL_s00215g274 and AOL_s00215g280 are involved in specific regional ketone reductions at respectively C-4 and C-1 of farnesyl epoxy-quinone PubMed:33823587 (Probable).
What are the official names of this protein?
Oxidoreductase AOL_s00215g277, Sesquiterpenyl epoxy-cyclohexenoids cluster protein AOL_s00215g277, SECs cluster protein AOL_s00215g277.
What is the protein family that this protein belongs to?
Belongs to the oxidoreductase OpS7 family.
Protein: ACCD_STRP1
Sequence: MALFRKKDKYIRITPNNSLKGSVSHNVPEVPDELFAKCPACKHMIYKKDLGLAKICPTCSYNFRISAQERLTLTVDEGSFQELFTSIETKDPLRFPGYQEKLQKAKETTGLHEAVLTGKAMVKEQKIALAIMDSHFIMASMGTVVGEKITRLFELAIEENLPVVIFTASGGARMQEGIMSLMQMAKVSAAVKRHSNAGLFYLTILTDPTTGGVTASFAMEGDIILAEPQSLVGFAGRRVIETTVRENLPDDFQKAEFLQDHGFVDAIVKRTELRDKIAHLVAFHGGGQ
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_PSESM
Sequence: MKRTFQPSTIKRARTHGFRARMATKNGRAVLSRRRAKGRKRLAV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: NHR13_CAEEL
Sequence: MPTNPNSCEVCSSSSNSSCNHFGARTCKACAAFFRRTVSMKLDYQCIDQPDACRVHCDSRVICRFCRLKKCHDIGMKPLLVKSKNERKNYIRISKGLIRKRSVLGDNVKENSEEIQNDDDPQESDAEMENESTPGPSSEPSENVSAENQETVTKFLKLEASMCDRRRLLYAETPISIVLESGKEWPYENAPLKMFDYKLSQGMSKHDFVMIMDYARGMPGFDEMNYADSVFCYRLVCAVDFVINSAYYTYKRGIEHNELVLSDGTFIPMVPTPLTGYEENANLLFQSQDDLMKFRTLMPLILHQWETCVPFAQLAPSHEEFCLLKAICVWHVSYYRLSEDGRRIAIAQRNRLIRALHHVCHLDSDDVGERFGNVMMALNYIMVNIRHVVSSFVMISFFGIINVDKSMISLTSFWNKSDTSTAPSL
What is the function of this protein?
Orphan nuclear receptor (PubMed:22511885).  Involved in regulating fatty acid desaturase genes, acting in concert with nuclear hormone receptor nhr-49 (PubMed:22511885).
What are the official names of this protein?
Nuclear hormone receptor family member nhr-13.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRE_NITSB
Sequence: MDIEKIYKESGALLKGHFLLSSGKHSPNYLQSAKVLEDPKKAELLAKELAKQIQAAGIEVDTVCSPAIGGLLAGYELARALGVRFIFTERKDGKMTLRRGFEVEPGEKVLICEDIITTGGSAMEAAKEMEKRGAEVVAFAALANRGVCQRTGSEIPSKSECKLPSNKTLFALADFTFPIYEPKECPMCAEGSEPIKPGSRGN
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.