PharMolix/UniProtQA huggingface dataset:
Protein: TRPA_ERYLH
Sequence: MTRLQNAFSKPHAAFVAFITAGDGDTAANLDALVAGGADVIELGMPFTDPMADGPAIQAANIRSLARGTTTRDVLMIANEFRERHPEVPLVLMGYANPMVRRGPEWFAAECKGCGVDGVICVDIPPEEDAELGPALRAAGIAPIRLATPTTDAKRLPAVLEGCEGFVYYVSVAGITGKQQAALDTIESNVARIKRSTDLPVAVGFGVRTPEQAGAIARVADGVVVGSALVELVGEFGTEAPAKLQELTKALADAVHSAR
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: TRMA_AGGAN
Sequence: MQNLPVTHYSALLAEKQEKLTALLAPFNAPNLQVFASPTQHFRMRAEFRIWHEGDDFYHIMFDQQSKQRYRVDNFPIASELINRMMTALLPLLKQQTVLHHRLFQIDYLSTQSQHIIVSLLYHKALDEDWQAAAQTLRSQLQQQGFNVQIVGRASKQKICLEQDYVDEILRVHGKDYIYRQVENSFTQPNATVNSKMLEWAVDCTRNSHGDLLELYCGNGNFSIALAQNFRKVLATEIAKPSVAAAQFNIAANQINNLQIIRMSAEEFTQAMQGVREFNRLKGIDLKAYECNTIFVDPPRAGLDADTVKLVQQYERILYISCNPHTLCDNLQTLSQTHRIEKAALFDQFPYTEHMEAGVWLVRKG
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: RS7_CARRU
Sequence: MSRKKRYFKTVILNDPKFGSYIIAKFISYIMNNGKKNLAQKIFYYSISIISIRLNKNPFILIKKILYNVQPDFEIKKKKIGGSVYKIPIKINLKRSLMFSMKWIVKNSKLRNENGYKNKLVGELIDSYYNNSLSTKQKDELNKIIDQNKAYSNFKI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ARAF_MOUSE
Sequence: MEPPRGPPVSGAEPSRAVGTVKVYLPNKQRTVVTVREGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEAPSNLSVNELLTPQGPSPFTQQRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTDAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPSEQRERKSLADEKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
What is the function of this protein?
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.  May also regulate the TOR signaling cascade (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase A-Raf, Proto-oncogene A-Raf.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Protein: ANM10_ORYSJ
Sequence: MASLPNGAASASASAAGGGPAVVDKEVDFANYFCTYSYLYHQKEMLCDRVRMDAYHSAVFRNAHHFRGKVVLDVGTGSGILAIWSAQAGARKVYAVEATNMAEHARELARANDVADIVEVIQGSMEDVVLPEKVDVIISEWMGYFLLRESMFDSVICARDRWLKPDGVMYPSHARMWLAPIRSDLAENKMEDLEIAMHDWNLFVEDTESYYGVNMNVLTKAYRAEHEKYYLKSAIWNNLHPNQVIGQAAVIKEIDCLTATVDEIREVRAQVTMPIKLDMTRLAALAGWFDVHFRGSKQNPATQEVELSTAPDVNGGTHWGQQVFLLTPPLKVNEGDNVKVSFTMVRSKENHRLMDMEFTYELHESSGKQLPAITTKIYLE
What is the function of this protein?
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
What are the official names of this protein?
Protein arginine N-methyltransferase PRMT10.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Protein: ATPH_RHDSA
Sequence: MNPIVSAASVVASGLSVGLAAIGPGIGQGTAAAQAVEGIARQPEAEGRIRGTLLLSLAFMESLTIYGLVVALALLFANPFTA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: LPXA_YERPB
Sequence: MIDKTAFIHPSSIVEEGAIIGAGVYIGPFCIVGSQVEIGAGTELKSHVVVNGITKIGCDNQIYQFASIGEANQDLKYAGEPTRVEVGDRNRIRESVTIHRGTTQGGGVTKVGCDNLLMVNTHVAHDCVIGNRCILANNAALGGHVEIDDYAIIGGMTAIHQFCVIGAHVMVGGCSGITQDVPPFVIAQGNHATPFGINIEGLKRRGFDKESLHAIRSAYKLLYRSGRTLDEVKPEIAELAEQYPVVKAFNDFFARSTRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIGB_YERPN
Sequence: MNILNLKIIMFLLISNTIVVGGAWATSTCPDWPATRIAVEINALEQQLNKWSAAYHQQGHSPVTDDIYDQLQDKLRVWQSCRGLPDKTESQPIPGKGQFLHPVAHTGLKKLKDETALTRWMAGRKNLWVQPKVDGVAVTLVYHGGKLVQLLSRGNGVKGQNWTEKAPFISAIPQYIANAPALLTLQGELFLLMDGHQQAKSGGVNARSTVAGALMRKSPSPLLAQVGVFIWAWPDGPTTMKEKVALLQVMGFPFTAKYSEPVMSHLDVVQWRQFWFQAPLPFVTDGVVVRQEEEPAGRYWQATPGQWSMAWKYPPLQHIAEVKDIHFTLGRTGKGTVVLEVLPIKIDDKWIRRVNIGSVTRWKQWDIAPGDHITLALAGHGIPRLDNVVWRVHQRNTITAPNWDKFHQLSCFQRLPHGCEPQFLSRLIWLSGPGGLDIGGIGGGFWQELIHHELINDLVGWLLLTPEQIASIPGIGNARAEKIYQQFQRAKQQPFSRWLLALGFPQVVSVDAQWQVVLRRSLSEWATMAGIGQMRAKQIKHFLDHPDVQALADFLSTQKVVGFELTE
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Protein: HIS3_MYCTO
Sequence: MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SKP1_ARTOT
Sequence: MAAAATSKITLTSSDGVDITIDRQVAERSILIKNMLKDLGDSGEAIPIPNVNESVLKKVIEWCKHHKGDPPSTGDDDVDSRRKTTDIDEWDQKFMQVDQEMLFEIILAANYLDIKALLDVGCKTVANMIKGKSPEEIRKTFNIQNDFTPEEEDQIRRENEWAEDR
What is the function of this protein?
Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
What are the official names of this protein?
E3 ubiquitin ligase complex SCF subunit sconC, Sulfur controller C, Sulfur metabolite repression control protein C.
What is the protein family that this protein belongs to?
Belongs to the SKP1 family.
Protein: NUOI_XANOR
Sequence: MMNKITHYFKSLLLLELLGGLWLTLKYTFKPKYTVLYPMEKFPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITIDSAKREDGTRRTTRYDIDLFKCIFCGFCEESCPVDSIVETHILEYHFEKRGENIINKPQLLAIGDRLETEIAERRAADAAFR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PGMD_ASPTE
Sequence: MAQPELDLSKAPAHWGMNFTETTHQQPSRSIDPSNVTFPQGYTVVVIGAGKGIGEHIAKAYVQARAENIIITSRTGSDLDRVKKELETLAQQTGQAVKVSTLVQDATKPESYTKLKDLLEEGFNGRLDTLVFCAGGGPVGTLWTPRIDETDVDEWNESIALNFTGSYYAAKYLVPLMLRPQSQGKTIVNITSAASHFTGGNITPASYSIGKLALNRFTQILGENYADQGLVVVAVHPGSSPTPGALGSMPPSLHNILTDDQGLCGAVCVWISKKKREWISGRYICATWDMDELESKKEEIVKEDKLKWRMAV
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of pleosporalin A, ascomycone A, as well as a third cryptic naphthoquinone derived pigment, all responsible for the coloration of conidia (PubMed:28471414, PubMed:35351612).  Essential for the production of pleosporalin A, but not the 2 other final products (PubMed:35351612).  The pathway begins with the biosynthesis of the cyclized heptaketide 3-acetonyl-1,6,8-trihydroxy-2-naphthaldehyde by the NR-PKS pgmA.  The C-6 hydroxyl group is further methylated by the O-methyltransferase pgmB to yield fusarubinaldehyde which is in turn oxidized by the cytochrome P450 monooxygenase pgmC at C-9.  The C-1 hydroxyl group is then methylated spontaneously.  Although pgmE, pgmD and pgmH are essential for the production of pleosporalin A, it is not the case for the 2 other final products and it remains difficult to assign a specific function to each enzyme.  PgmF and pgmG seem not to be involved in pigment biosynthesis although they were regulated by the cluster-specific transcription factor pgmR (PubMed:35351612) (Probable).
What are the official names of this protein?
Short chain dehydrogenase pgmD, Pigmented naphthoquinones biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MDTK_SALEP
Sequence: MQKYTSEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSVLVMIVLWNAGYIIRSMHNIDPALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFLGLLVNIPVNYIFIYGHFGMPELGGIGCGVATAAVYWVMFIAMLSYIKHARSMRDIRNEKGFGKPDSIVMKRLIQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVGYRLGQGSTLDAQTAARTGLGVGICMAVVTAIFTVTLRKHIALLYNDNPEVVALAAQLMLLAAVYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYILALTDLVVDRMGPAGFWMGFIIGLTSAAVLMMLRMRYLQRQPSAIILQRAAR
What is the function of this protein?
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
What are the official names of this protein?
Multidrug resistance protein MdtK, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ERA_ACIFD
Sequence: MDPDDAPPIRRSGFVAVIGRTNVGKSSLVNALAGERATIVSRHPNTTRRSVRVISRVGDAELVLVDTPGIAAAHDELSARLRRWVDDEWDGADRALLVVDAERGVGARERELASRLKPSDVAVVARIDRVRRARTLAVLAELAQVPLAEYFVASVRTGEGIEELRSYLASSLPEGPALYEAGVALDLPRATYVAEVVREEFLHHLRDELPQALACQVESWSDDGVEVVVYVERPSQRAIVLGHEGRVLAAVRRQAQRRLRAYPPLTLRVKVQRDWRRSARMLDELGL
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: GLMM_BURCM
Sequence: MGRRYFGTDGIRGTVGEAPITPDFVLRLGYAAGKVLAGTADVAAGARPTVLIGKDTRVSGYMLEAALEAGFSAAGVDVMLAGPMPTPGVAYLTRALRLSAGVVISASHNPYQDNGIKFFSADGNKLPDETEAAIEAWLDKPLECASSDRLGKARRLEDAAGRYIEFCKSTFPAAYDLRGLKLVIDCAHGAAYQIAPHVFHELGADVIPIGVAPNGFNINDGVGATAPDALVRAVRANHADLGIALDGDADRLQVVDSTGRLYNGDELLYVLVKDRIATAGKVDGAVGTLMTNLAVEVALQREGVPFVRAAVGDRYVLEQLRERGWQLGAEGSGHILSLDRHSTGDGIVSALLVLAALKRSDRTLAQMLDGVTLFPQKLINVRMKPGADWKGSASIRAAIDAAEGALAGSGRVLIRASGTEPVLRVMVEAQQAADATRHAEAIADAVRMATS
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MSHC_MYCVP
Sequence: MNQPSDLSHTSMSRVEAMHSWSAPNVPALPGRGPQLRLYDSADRQVRPVAPGATATMYVCGITPYDATHLGHAATYLTFDLVHRLWRDSGHDVHYVQNITDVDDPLFERAQRDGIGWRELGDRETELFREDMAALRVLPPRDYVAATEAIAEVVELVEKMLAAGAAYVVDDPQYPDVYFRADATVQFGYESGYDRDTMLALFAERGGDPDRPGKSDPLDALLWLAERPGEPSWPSPFGPGRPGWHVECAAIALSRIGTGLDIQGGGSDLIFPHHEFSAAHAECVTGERRFARHYVHAGMIGWDGHKMSKSRGNLVLVSQLRRDGVDPAAIRLGLFAGHYRDDRFWSPAVLDEALARLHRWRSATALAGAPDATDVVARVRRYLADDLDTPKALAALDGWATDALTYGGHDATAGTTVATAVDALLGIAL
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: SGF11_DROYA
Sequence: MSAANMPTTTGAQGSGNQVPTTSTTIVNHFRELIKDPKNLDEASKYLFQTLLDDAVVGIFNETHHLRKSGNLAALDGVPEDSTYRMCEMPNLDIFGISTAKKPMDCTCPNCDRLVAAARFAPHLEKCMGMGRISSRIASRRLATKEGASSAHLHSAGNAGGTDDEDDVDWSSDKRRKKSNQNSRNNGSKKNNGKTF
What is the function of this protein?
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Binds independently on SAGA to promoters in an RNA-dependent manner.  Binds to mRNA and is essential for total mRNA export from the nucleus.  Required to counteract heterochromatin silencing.  Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe.  Required for expression of ecdysone-induced genes such as br/broad.
What are the official names of this protein?
SAGA-associated factor 11 homolog.
What is the protein family that this protein belongs to?
Belongs to the SGF11 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
Protein: SCNNA_HUMAN
Sequence: MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP
What is the function of this protein?
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride.  Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells.  Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.  Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands.  Also plays a role in taste perception.
What are the official names of this protein?
Amiloride-sensitive sodium channel subunit alpha, Alpha-NaCH, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, ENaCA, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA.
What is the protein family that this protein belongs to?
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cytoplasmic granule. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non-ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution (PubMed:28130590). In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles (PubMed:28130590). In eccrine sweat glands, mainly located at the apical surface of the cells facing the lumen (PubMed:28130590). In skin, in arrector pili muscle cells and in adipocytes, located in the cytoplasm and colocalized with actin fibers (PubMed:28130590). In spermatogonia, spermatocytes and round spermatids, located in the cytoplasm (By similarity). Prior to spermiation, location shifts from the cytoplasm to the spermatid tail (By similarity). In spermatozoa, localizes at the acrosome and the central region of the sperm flagellum (By similarity).
Protein: IL18_CHICK
Sequence: MSCEEIAVCAVRLRENLCLYFEELECDAFCKDKTIKRFFRNVNSQLLVVRPDLNVAAFEDVTDQEVKSGSGMYFDIHCYKTTAPSARMPVAFSVQVEDKSYYMCCEKEHGKMVVRFREGEVPKDIPGESNIIFFKKTFTSCSSKAFKFEYSLEQGMFLAFEEEDSLRKLILKKLPREDEVDETTKFVTSHNERHNL
What is the function of this protein?
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-18, IL-18.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: THAP2_HUMAN
Sequence: MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEANSVLPKGTSEHMLPTALSSLPLEDFKILEQDQQDKTLLSLNLKQTKSTFI
What are the official names of this protein?
THAP domain-containing protein 2.
Protein: PYRB_CLOBA
Sequence: MIKDKHLIDPMDFTVEELKEIFKLAHEIILDPEKFSHVCDGKILGTLFYEPSTRTRFSFEAAMMRLGGKILGFSEPNSSSASKGESLSDTIKMVSIYTDIIAMRHPKEGSAKVASLYSSVPIINAGDGGHQHPTQTLTDLLTIEMLKDGLSNHTIGICGDLKYGRTVHSLIKAMSRYKGNKFLLISPKELRIPDYIREEILRKNNIEFLEVETLEEVIDKVDILYMTRIQKERFFNEEEYLRLRDSYILNKEKMNLAKDDMIVMHPLPRVNEIACEVDYDKRAAYFKQAEYGMYARMALMAKLLGVL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: ISPE_BARQU
Sequence: MMSDVKVSFKGHSYVFTPIKLNLTLHVVGQRTDGYHLIESLVYFSFSGDCLSYMPCKSNHFILTGPFADELVSDTGNLVVRAHDFMCKAFPKCAKPAFFRLVKLLPVASGIGGGSGNAAGVLSLLRQQWGLDCSCEKLAEMSLVLGADVPMCLFALEYRQPLFVRGIGQDITQLKEACSLAMVLVNHGQQIATKAVFKALEKRDHPPLKIDLESLKTVDSLVEALQETRNDLFIPALKIAPQLSEVLYALDESGALFSRMSGTGATCFGIFKDKEAAQQAALFIKLMHPDWFVKPIITLGML
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: LPXB_ECOSE
Sequence: MTEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: DNAA_STAEQ
Sequence: MSEKEIWDKVLEIAQERISNTSYQTFIKDTQLYSLKNDEAIILVSLPFNASWLNQRYSEIMQAIIYDVIGYEVKPHFISEDELASYNNVNTQEVQEPQVQHSSIDDKTWGKEQFNMHNTFDTFVIGPGNRFPHAASLAVAEAPAEAYNPLFIYGGVGLGKTHLMHAIGHHVLSNKPNAKVIYTSSEKFTNEFIKSIRDNETEAFREKYRKIDVLLIDDIQFIQNKEQTQEEFFHTFNELHQNNKQIVISSDRPPKEIAKLEDRLRSRFEWGLIVDITPPDYETRMAILQKKIEEENLDIPPEALNYIANQIQSNIRELEGALTRLLAYSKLQGKPITTELTAEALKDIIQSPKSKKITIQDIQKIVGQYYSVRIEDFSAKKRTKSIAYPRQIAMYLSRELTDFSLPKIGEEFGGRDHTTVIHAHEKIANDIKSDPTFKQEVENLEKEIRNQ
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_SHEB8
Sequence: MNVILLDKIANLGNLGDQVSVKAGYARNFLLPQGKAVVANESNVKVFEARRAELEAKLAAELAAANLRAEKITALEAVVIASKAGDEGKLFGSVGNRDIADAVTAAGVELAKSEVRLPLGALRTTGDFEVEVQLHTEVKAVVKVSVVAEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.