PharMolix/UniProtQA huggingface dataset:
Protein: HRCA_STRAL
Sequence: MLSERRLEVLRAIVQDYVGTEEPVGSKALTERHRLGVSPATVRNDMAALEDEGYIAQPHTSAGPIPTDKGYRLFVDRLADVKPMTAPERRAIHHFLDQAVDLDDVVARTVRLLAHVTRQVAVVQYPSLTRSTVRHVELLSMAPARLMLVLITDTGRVEQRMIDCPAPFGESSVADLRARLNSQVAGRRFADVPQLVQDLPESFESEDRPTVSTVLSTLLETLVEETEERLMIGGTANLTRFGHDFPLTIRPVLEALEEQVVLLKLLGEAKDSAMTVRIGHENAHEGLSSTSVVSVGYGSGREAVAKLGVVGPTRMDYPGTMGAVRAVARYVGQILAES
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ACHB_RAT
Sequence: MALGALLLILGILGTPLAPGARGSEAEGQLLKKLFSDYDSSVRPAQEVGDRVGVSIGLTLAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIESLRVTAESVWLPDVVLLNNNDGNFDVALDINVVVSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGPDPDGQERQEIYIHEGTFIENGQWEIIHKPSRLIHLPGDRRGGKEGHREEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMILVTFSVILSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYLGLKRPKPERDQLPEPHHSFSPRSGWGRGTDEYFIRKPPCDFLFPKLNRFQPESPAPDLRRFIDGPPRAVGLPQELREVISSISYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDATYHLPPPEPFP
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: NMRL1_CHICK
Sequence: MTSKKLIVVFGATGAQGGSVARALLEDGAFAVRAVTRSPGRKEAAELRRRGAELMRADQDDERSLEEALTGAHGAFVVTNFWEHCSKEKEVAQGRRLADLSKRLGLQHVVYSGLENVKQLTKGRLEVLHFDGKGEVEEYFRAVNVPTTTIRLPFYYENFLSSFKPQKAPQGDKLLLGLPMGDTPMDGMAVEDLGPIVLSLLKSPEQYIGQVIGLSAGKLTVAEYAAAFSQQTGKTVEDSKITPEEYEKLGFPGAKELADMFRFYALKPDRNVELTMKLNPKARTFQQWLADNKAAF
What is the function of this protein?
Redox sensor protein.  Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels (By similarity).
What are the official names of this protein?
NmrA-like family domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
Protein: MURE_PROMA
Sequence: MNYQLHELFKAVGIHRQIVGKDLIIDSISCDSRHISKGGLFFGLPGEKVDGGIFWRKALASGAVAAVIGEEAAQKDPPSNEDMVFVVSDPVAHWMGEMASVFWKRPSSQIDLIGVTGTNGKTTTTYLIEHLCKQSGITSALFGTLYNRWPKHSEVAIHTTAFGDVLQSQLAQAVAAGARLGVMEISSHALDQRRVAGCSFSGAVFTNLTQDHLDYHESMEAYFQSKALLFQAPLLRDKESCSVVNIDDPWGLRLSKQLNKSCWRASLEKRVIDSIQPELFLTDLNITNKGIEGVLHSPFGQGPFVSSLIGRFNLMNMLEAVGILIQHGVSLQELLPSIKSFSGVPGRMEQIKVEGDLPVVLVDYAHTPDGLKNALIALRSFGSGRLFCVFGCGGDRDRSKRPLMGAIASKFADHVTLTSDNPRTEDPQQILNDVLPGIATETELIIEIDRANAIQMAIMKALPGDIVLIAGKGHENYQILGLETIEFDDREIAKKILHLKLNP
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_EHRCR
Sequence: MGYVVSTFYRFVHLSNYYDIQPVLKEFCVQHSIKGTIILAEQGINATIAADKQSSLDEFFSFLNLDDRLKDIRYHKSFAMHNPFSKMKVKLRKELVCLGIEDFDNSVCGEYVSPQDWDDLISRSDVYTIDTRNTYEINFGKFKNAINPQTKCFRDFPEWAISWASNKVDQDPIIAMYCTGGIRCEKSTAFMKDLGFSKVYHLKGGILEYFKSTQNKNSLWEGDCFTFDDRIAVDNKLVPAHVKCVSCDVCVTPEEMKSITRGHVLCFNCKENVKI
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: GPDA_ECOSM
Sequence: MNQRNASMTVIGAGSYGTALAITLARNGHEVVLWGHDPEHIATLERDRCNAAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFGEVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDQTFADDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVQSAQEKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKDERSSH
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP7D_CHLMU
Sequence: MNSKFYHRSRLFLTFGEASEIWLSTLSPLTRKNYASGIKFLVSLKVLDLTKTLDNAISFDHSESLFKIKSLTIFNGKPVSEASKQARAACYISFTKFLYRLTKGYINPAIPLKDFGNTTFFKIRDRVKTVSISKKEWTVFFEALRLVSYRDYLIGKLIVQGIRKLDEILSLCMEDLFFASNQISFRIKKRQNKEINIPITFPFSLMKELKDYVGGRNGRVFISEDGSPIATSQVVHNFKIAALRSAMTTKITPRVLRASALIHLKQMGLRDEEIMRVSCLSSKQSLCSYVCSGGNSSVANIPTIL
What are the official names of this protein?
Virulence plasmid integrase pGP7-D.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: SOCS1_MOUSE
Sequence: MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI
What is the function of this protein?
Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:9202125, PubMed:10064597, PubMed:15169905, PubMed:15522878).  Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway.  Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity (PubMed:9202125, PubMed:10064597, PubMed:15522878).  In vitro, suppresses Tec protein-tyrosine activity (By similarity).  Regulates IFN-gamma (IFNG)-mediated sensory neuron survival.  Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1.
What is the protein family that this protein belongs to?
Belongs to the SOCS1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Protein: PGTB2_HUMAN
Sequence: MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
What is the function of this protein?
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
What are the official names of this protein?
Geranylgeranyl transferase type-2 subunit beta, Geranylgeranyl transferase type II subunit beta, GGTase-II-beta, Rab geranyl-geranyltransferase subunit beta, Rab GG transferase beta, Rab GGTase beta, Rab geranylgeranyltransferase subunit beta, Type II protein geranyl-geranyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit beta family.
Protein: DEOB_ECO8A
Sequence: MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDHENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTNGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHTREHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBK_CROS5
Sequence: MEAVFLLAKLPEAYQIFDPLVDVLPVIPVFFLALAFVWQAAVGFK
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: SYP_CAMJJ
Sequence: MMRFTKFYAPSLKEAPKDASLPSHIFLTRAGFVEQIGSGLYNFLPLGKRVLDKIKNIVKEEMDKAGAQEVNLSFITPASLWQESGRYNVFGKELLRFKDRKKNEFVLGPTHEEAMLSLVKNKITSYKQLPLHLYQIGLKFRDEARPRFGLLRCREFLMKDGYSFHANEEDLGREFELMYKTYSQILQRMGLDFRAVEADSGAIGGSGSKEFMVLAKNGEDDILICENCDYAANVEAAKRAKKTCQDERPEANYASKFHTPNIKTIDSLAQFFKINAFYTIKAVVKKAIYENESKLVVFFIRGSDDLQEIKAQNACSALELVDASEEELEKAGLVAGFIGFVGLKDIDFYIDFELENEKQMIMGANEKDYHLIGIDVVNLNKDRFKDLIEVKEGDCCVKCGAKLKQSKGIEVGHIFKLGQKYSKAMNANFLDENGKSQPFYMGCYGIGVSRLLAVAIEANHDEKGCIWNKTLAPFVLEIIVSNLKDEKALEFANKLYEDLTNLGLEVLLDDRNERFGVKMNDFELMGFPYALVIGKGLENNEIELIQREDLVKELIKTDELMEILKKKVL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEF_HV1B1
Sequence: MGGKWSKSSVIGWPAVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAANNAACAWLEAQEEEKVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: SHE9_YEAST
Sequence: MLRYYGATRNLPLVFSINKLMLRASSFTRPFHYSSYSLQNGDTPDKGSTNKNEIRTPNNAVWKENIELQWQHLKKKLNELYSRFNFHRDQLSFQVNKAKKSIQEANRKLSEQENEINDSRLNYNKDELTSAKIEGLPSEREQHRKKWSRKLEFYFDSLQETLFTATRALNDVTGYSGIQKLKSSISLMEKKLEATKKEHKLFKAQYANAIDERAQSQREVNELLQRQSAWSSSDLERFTQLYKNDALNARQEQELKNKVKEIESKEEQLNDDLYRAILTRYHEEQIWSDKIRRTSTWGTFILMGMNIFLFIVLQLLLEPWKRKRLVGSFEDKVKSALNEYAKEQNMKMDKLLPGKSSEVTDQGNTENSIVEEHIEQRGECKINTAEIDRPEVATAETTTTEMKSFRDIWERIKALFVTLKSIQYRKLDAPLVFDTLEFYLYSISLVSMTILVSGLI
What is the function of this protein?
Required for the maintenance of the structure of the mitochondrial inner membrane.  Involved in mitochondrial morphology.  Causes growth arrest when highly overexpressed.
What are the official names of this protein?
Sensitive to high expression protein 9, mitochondrial, Mitochondrial distribution and morphology protein 33.
What is the protein family that this protein belongs to?
Belongs to the SHE9 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GLPK_BURCH
Sequence: MQDQYILALDQGTTSSRAMLFDRQGNIVSIAQKEFEQIYPQPGWVEHDPQEIWSTQAGVAAEAVTRTGLNGTSIAAIGITNQRETTIVWDRETGQPVYNAIVWQDRRTADFCDSLKKQGLEAKVRAKTGLPIDSYFSATKIRWILDNVPGARDKARQGKLAFGTVDSWLVWNFTKHELHVTDVTNASRTMLFNIHTREWDSELLELLDIPRSMLPEVKASSEIYGHTKTTVFASKIPLAGIAGDQHAALFGQMCTTSGMVKNTYGTGCFLMMNTGDKPIESKNNLVTTIAWQIGDDVQYALEGSIFIAGAVVQWLRDGVGLIKTAAEIEALAASVPHTDGVYLVPAFAGLGAPHWNARARGSVFGVTRGTSAAHLARAALDAIAYQSLDVLAAMEADSGISIGELRVDGGASANDLLMQFQADLLGVDAVRPQITETTALGAAYLAGLAIGYWKNLDEVRDQWQLDRRFAPSMPKEQVEQRMAGWQRAVRAAKAWADDTQ
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: TAL_CLOAB
Sequence: MKLFIDTANVEEIKEVNDMGVICGVTTNPSLVAKEGRDFNEVIREITSIVDGPISGEVIALDAEGMIKEGREIAKIHKNMVVKIPMTEEGLKAVKVLSSEGIKTNVTLIFSAGQALLAARAGATFVSPFLGRLDDIGADSIGLIESIVNIFDIHDIRTEIIAASIRSPKHVIDSAEAGAHIGTVPYKVLKQLIKHPLTDIGIERFMKDWKEAFNK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_CLOBH
Sequence: MYNCAIILAAGKGKRMKSSMPKVVHKVCGKEMVNHVIDNVRKANIKDVNLVIGKGSETVKEHTKDRNVTYSMQEEQLGTGHAVICAEEFLKDKKGTVAIFTGDAPLITNETIQQLFEFHNSGKYAATLISSTVQDPTGYGRIIREASGEVKKIVEHKDCNEEELKVNEINSGMYCFDIEVLLNSLKNLNNDNSQGEYYLTDVIEITKKSGDKVGAIVVPYEEIMGVNSRVQLSEAEIVMRKRINHKHMVNGVTFIDCESTYIDVDVEIGNDTIIYPGCVIQGNTRIKEECTLYSNSRICNSVIGSGVIVENSVILESHVGEGTTVGPFAYIRPETKIGKSARIGDFVEIKKSTIGDNTKVSHLTYIGDAEVGSKCNFGCGTVVVNYDGQKKQKTIIGNNAFIGCNTNLISPVKVNDNTYIAAGSTITKEVPEGSLAIARSKQINKEGWLDKKGLLKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRIH_BOVIN
Sequence: MTTASPSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAERLMKLQNQRGGRIFLQDIKKPDRDDWENGLTAMECALCLERSVNQSLLELHKLATEKNDPHLCDFIETHYLNEQVEAIKELGDHITNLRKMGAPGSGMAEYLFDKHTLGHSES
What is the function of this protein?
Stores iron in a soluble, non-toxic, readily available form.  Important for iron homeostasis.  Has ferroxidase activity.  Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.  Also plays a role in delivery of iron to cells.  Mediates iron uptake in capsule cells of the developing kidney (By similarity).
What are the official names of this protein?
Ferritin heavy chain, Ferritin H subunit.
What is the protein family that this protein belongs to?
Belongs to the ferritin family.
Protein: NQRF_HAES1
Sequence: MEITLGIAMFTVIVLALAVLILFAKSKLVNSGDITIEINDDPGKAINLPAGGKLLGALANKGIFVSSACGGGGSCGQCIVKVTEGGGDILPTELSHISKREAKEGYRLSCQVNVKNSMKIELPEEVFGVKKWECTVISNDNKATFIKELKLQIPEGEEVPFRAGGYIQIEAEPHTVHYKDFDIPKEYHEDWDKFDLWRYTSKVDEHIIRAYSMASYPEEKGIIMLNVRIATPPPRNPDVPPGQMSSYIWSLKEGDKVTISGPFGEFFAKETDNEMVFIGGGAGMAPMRSHIFDQLKRLKSKRKMSFWYGARSKREMFYVEDFDMLQAENDNFVWHVALSDPLPEDDWDGYTGFIHNVLYENYLKNHEAPEDCEYYMCGPPVMNAAVIKMLKDLGVEDENILLDDFGG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit F, Na(+)-NQR subunit F, Na(+)-translocating NQR subunit F, NQR complex subunit F, NQR-1 subunit F.
What is the protein family that this protein belongs to?
Belongs to the NqrF family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL1_TROW8
Sequence: MTKRSKAYRSAVTSIASDKLYPVEDAIGLVKETAYAKIDSAFEVALKLGIDPRKTDQLVRGVVMLPHGTGKAVRVVVFATGPSAQAALDSGASEVGGSDLVARVADGYVDFDVAISTPELMAQVGQLGRVLGPRGLMPNPKTGTVTADVGKAVKDALGGRIEFKTDKHANIHFVIGKTSFSVESLSENLSVALDEINRARPQKHKGRYIKKMFFSSTFGPSVRVALA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: ATP25_BLAGS
Sequence: MRRALLTGIQCHACRNNVVRSFVSVSGVTFMPLASGSWSASQTRPPPLSRNFSSQHAKLFSSHPSDNAEVAVDPMPEKDITEETVKPPEEPEEHIPWYLQEELEATTSHPLRKQQPLPPLPENPPPILNGLLEHISIDLGLDDISLLDLRKLDPPPALGANLIMIFGTARGVKHLNVSADRLCRWLRTTYKLRPDADGLLGRNELKIKLRRKARRAKLAKSAKSTLTAPDDGITTGWICVDVGTVEGGQFRKPEEEARKVGFVGFGTFVQGTRIVVQLMTEEKREEVDLEGLWRRTLERNSLENEGLPQPQAEEPPQEAGDIHKPSSVTPAHISHRVSHAAQISVNYEQRRGISTGSRQNRDLEEDGLNYAPINPDGTIKLPELISESTPLTSLTSRLRNISPYEAIYHLGQDVNDTNSTTFLEQFYRKLSKAPDDLASAQRIKLICIAIMLHHPGYGKTDLFKVTQEHFISNYGVTPPQFLEILDALLSFKPDLTSDPPNLLLPAADMELALQTIDHVGLRGIDLLNSTVWMKLFVGASFRVPVCPVRDLMNAPVIGNRTPVSLDTYETVNRVQTRLLKVKTAAKIELSANEYLSLLRVLFDHEWYSMFWDTWEEIALAGMPRDKSLYVFLFQLHAESDGWEGWKSTLLNCIPMMERENPPVYMDRELAEVIARCLAIAHPEIMDRVERNEPSPLVRLWHRCRIAVEKEVPLRGAQNPPSTMS
What is the function of this protein?
Probable mitochondrial mRNA stabilization factor.
What are the official names of this protein?
ATPase synthesis protein 25, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATP25 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: DHSD_RICBR
Sequence: MTYDFRAEIVKAKNTGSAKSGSHHWLLQRITAIILVLCSLWLLYFTLANKNSDVNIIIWELKRPINLIPLLIAVITSLYHAMLGMQVVIEDYISCNKLRNTLIIAVKLFSILTIVAFIVAVFYRG
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase hydrophobic membrane anchor subunit.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IL12B_SIGHI
Sequence: MCHQKLTISWFAMVLLVSPLMAIWELEKDVYVVEVDWSPGAPGERVVLTCDTSEEDDIIWTSDQSSEVVGSGKTLIVQVKEFSDAGQYTCHKGGETLSHSRLLLHKKEDGIWSTDILKDQKDPKNKTFLKCEAANYSGRFTCWWLTAVSTDLKFSLKSSSSSSDSRSVTCGAASLSTEKVTVDQRDYNKYSVACQEDITCPTAEETLPIELVMEAQHKYKYENYSTGFFIRDIIKPDPPKNLQLKPLKSSQVEVSWEYPDSWSTPHSYFSLKFFVQVYRKKEKKGESLLVDKPSAKIRCSKGGEVRVRAQDHYYNSSWSEWASVSCN
What is the function of this protein?
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.  IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.  IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines.  IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
What are the official names of this protein?
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40.
What is the protein family that this protein belongs to?
Belongs to the IL-12B family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y279_BRUAB
Sequence: MTADVPNARLVDVELDESIGRSTPDVEHERAVAIFDLIEENSFHPVGDQKGGPYRLKLSLMESRLIFSITRENGDAVATHILSLTPLRRVVRDYFMICESYYQAIRSATPSKIEAIDMGRRGLHNEGSQTLQARLKGKIEVDFDTARRLFTLVCVLHWRG
What are the official names of this protein?
UPF0262 protein BruAb1_0279.
What is the protein family that this protein belongs to?
Belongs to the UPF0262 family.
Protein: CR3L1_HUMAN
Sequence: MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFSNDLFSSFFDDPVLDEKSPLLDMELDSPTPGIQAEHSYSLSGDSAPQSPLVPIKMEDTTQDAEHGAWALGHKLCSIMVKQEQSPELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPGEMTQLPVIKAEPLEVNQFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTAISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTLLQQLQKLQTLVTNKISRPYKMAATQTGTCLMVAALCFVLVLGSLVPCLPEFSSGSQTVKEDPLAADGVYTASQMPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDGGNGTSPDFSHSKEWFHDRDLGPNTTIKLS
What is the function of this protein?
(Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells.  Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813).
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3-like protein 1, cAMP-responsive element-binding protein 3-like protein 1, Old astrocyte specifically-induced substance, OASIS.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Nucleus. Note=Upon ER stress, transported into the nucleus.