PharMolix/UniProtQA huggingface dataset:
Protein: LOLD_BURL3
Sequence: MNDRATAFADSRQHNRQDSAGMQEYVLQARGVTKAFVQGGFNVQVLNNTELTVRRGEKLAVVGASGSGKSTLLHVLGGLDEPSAGEVSLLGKPFTQLAERERNELRNRALGFVYQFHHLLPEFTALDNVAMPLRIRRMTTEDAREQAQTMLERVGLGPRAKHRPGELSGGERQRVAIARALVTKPACVLADEPTGNLDGTTADTVFNLMLELSETLETSFVIVTHDPDLAARCDRIMRLRDGVLHEEPALPV
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y9871_DICDI
Sequence: MATLDLCNNEHLNETESADEEDDQLQTPIKTVVTLKFKENPDSTSPIQVFQLNIGSNIIGRGSPSFLNDIKISRRHAEIIVSAEVGNVTFNQLGQNHSTLYRKDQTPIKMVRGISNQLLDDDLISLYDGSIPFSIHIERDNQFMSVCEGNFILTQDAADTNYHINSPTKTITTTSTTTTTTETLIKNIDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSILSKRSRDNENNHNHQYIHHDKTPLTLQQQQQLQNQQQLHQQQQQQLQYEQLQQLQQLQQHQQQQQHQQQQQQQQQQQQQQQQQQQQQQFKKHKRENTPVIVEDSLKLNIQENELLFIKKIGSGACGEVCQYEWKGTPVAVKTIFKSLLRKDKKEEFEKEVSILKCLRHPNVVLFMGTCLLNGNLAIITEYLNRGSLRDVLTTMNKSELSLSVKVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNNFNVKVSDFGLSRFISGGIGSSAKTFCGTLSWIAPEVFNGSGYTTKVDVYSFGIVLWEILTHKQPSGNISATSLGHPELPSNCPQSFSDLIKECCNRNPDQRPNFSQILLKLKLMYNQINNNNNNNKIDSSSFHNNNNNCSYNNSNDNNGILVTGGVGGNVSGNVESNNNNNNNTLNGAGNVIILNEIKDFTIQPNEITNIKTIIVKDSYSILEGQYKGKLVSIKQINGSINDFEMKQLGVLASIKSPLAVRFIGVVFNTDEYAIISEHVGNNGSLLTLMQNHSNQLNWSNTIDLAIQITQSIQYLHKHQPPILHRNITSDCFLLSSLNNNSNQNNNNNNNNNNNNNNNNNNNNNNNKKNDGGDDNGENTNTTTTTTTTTTTATNITNELNINEIKIKVHDFGLSRFNTQENEESLKEIKGNFLYSPPELLSLNTYSNKSDIYSLSIVLYELFETCLTKTYKKPYHEVTLDFDFQIIHKTSKLNLRPTISNNMPNEISKILQQGWFSDSVLRPSLDTIIKELLICKKNLC
What are the official names of this protein?
Probable serine/threonine-protein kinase DDB_G0271682.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Protein: LPLA_SHIDS
Sequence: MSTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEVDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTSIVLNALNALGVSAEASGRNDLVVKTVEGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITSVRSRVTNLTELLPGITHEQVCEAITKAFFAHYGERVEAEIISPDKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDERFSWGGVELHFDVEKGHITRAQVFTDSLNPAPLEAFAGRLQGCLYRADMLQQECEALLVDFPDQEKELRELSTWIAGAVR
What is the function of this protein?
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
What are the official names of this protein?
Lipoate-protein ligase A, Lipoate--protein ligase.
What is the protein family that this protein belongs to?
Belongs to the LplA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDMG_TALVE
Sequence: MDYFYGTSPPPEYERYASIVDAATLVQGFLWALNYGEASYRSIKDRTYGMAIFPLCCNYAWELVYTVIYSSQNKYERIIMTTWLILNSIMMGFTIKFAPNEWRHAPLVQRNIPFIFLAGVAAFVIAQLALAATVGPGLAMNWVAALCYLLLTIGSLCQLMTRGSSRGVSYTMWLSRFVGTYVGVICVYFRYNYWPQNFSWVDEPIMKCFSGISLAVEIVYGVTLWHIRKQERHHIVEKSK
What is the function of this protein?
Terpene cyclase; part of the gene cluster that mediates the biosynthesis of chrodrimanin B, a meroterpenoid that acts as a potent blocker of insect GABA-gated chloride channels (PubMed:30417647).  The first step of the pathway is the biosynthesis of 6-hydroxymellein by the polyketide synthase cdmE (PubMed:30417647).  The prenyltransferase cdmH acts as a 6-hydroxymellein 5-farnesyltransferase and produces the hydrophobic metabolite verruculide C (PubMed:30417647).  The FAD-dependent monooxygenase cdmI further converts verruculide C into verruculide B (PubMed:30417647).  The terpene cyclase cdmG then produced the pentacyclic molecule 3-hydroxypentacecilide A, the backbone structure of chrodrimanin B, via folding the farnesyl moiety of the substrate into the chair-boat conformation (PubMed:30417647).  The short-chain dehydrogenase/reductase cdmF functions as the 3-OH dehydrogenase that oxidizes the C-3 hydroxyl group of 3-hydroxypentacecilide A and produces chrodrimanin C, the dehydrogenated product of 3-hydroxypentacecilide A (PubMed:30417647).  The cytochrome P450 monooxygenase cdmJ then accepts both 3-hydroxypentacecilide A and chrodrimanin C and functions as a C-7-beta-hydroxylase to produce respectively chrodrimanin H and chrodrimanin F (PubMed:30417647).  The dioxygenase cdmA accepts chrodrimanin H to afford chrodrimanin E, which is further transformed to chrodrimanin A by the dioxygenase cdmD (PubMed:30417647).  CdmA can also accept chrodrimanin C as substrate to convert it into verruculide A, which is further converted into chrodrimanin T by cdmD (PubMed:30417647).  The last step of the biosynthesis is proposed to be performed by the acetyltransferase cdmC which acetylates chrodrimanin A to yield chrodrimanin B (Probable).  The pathway may also lead to the production of additional shunt products, including chrodrimanins T and U (PubMed:30417647).
What are the official names of this protein?
Terpene cyclase cdmG, chrodrimanin B biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the paxB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: T1MK_ECOLI
Sequence: MNNNDLVAKLWKLCDNLRDGGVSYQNYVNELASLLFLKMCKETGQEAEYLPEGYRWDDLKSRIGQEQLQFYRKMLVHLGEDDKKLVQAVFHNVSTTITEPKQITALVSNMDSLDWYNGAHGKSRDDFGDMYEGLLQKNANETKSGAGQYFTPRPLIKTIIHLLKPQPREVVQDPAAGTAGFLIEADRYVKSQTNDLDDLDGDTQDFQIHRAFIGLELVPGTRRLALMNCLLHDIEGNLDHGGAIRLGNTLGSDGENLPKAHIVATNPPFGSAAGTNITRTFVHPTSNKQLCFMQHIIETLHPGGRAAVVVPDNVLFEGGKGTDIRRDLMDKCHLHTILRLPTGIFYAQGVKTNVLFFTKGTVANPNQDKNCTDDVWVYDLRTNMPSFGKRTPFTDEHLQPFERVYGEDPHGLSPRTEGEWSFNAEETEVADSEENKNTDQHLATSRWRKFSREWIRTAKSDSLDISWLKDKDSIDADSLPEPDVLAAEAMGELVQALSELDALMRELGASDEADLQRQLLEEAFGGVKE
What is the function of this protein?
The subtype gamma methyltransferase (M) subunit of a type I restriction enzyme.  The M and S subunits together form a methyltransferase (MTase) that methylates A-2 on the top and A-3 on the bottom strand of the sequence 5'-AACN(6)GTGC-3'.  In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site.  Whether the DNA is cut or modified depends on the methylation state of the target sequence.  When the target site is unmodified, the DNA is cut.  When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated.  After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
What are the official names of this protein?
Type I restriction enzyme EcoKI methylase subunit, M protein, Type I methyltransferase M.EcoKI, M.EcoKI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: YM91_CAEEL
Sequence: MSPHKDFQSSSTPVPVCMENDPNCDLLRYLIALAIFIGLIAIFMFGCKAAMRLLTRKRNRDTTQSDTDVIYPRDDPRASRSHQNFGFMDPPPRYEQIFKRGGGTPSVITTREAPSVTRSTGDGSLPPSYEQAALNARRESRPQLPQGTLREVPLTAIDMEHPAMSTPSSTVLDMESEITNITNHAQACVHRYDASHANEVTRTAVAVTTESPAPAQSTSNALPELEAPEGGPPGYDTISLHNETVSTR
What are the official names of this protein?
Uncharacterized protein M01A8.1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FLIL_CAUVN
Sequence: MAKKPEKEAPAPEGEEGAEGEAPAKKKPPILIIAIAAGVLVLGGGGAAAFFLLKPKPAAEAGEHGEKKEEKKKEKKKEEKGDKKDAEKGAEGAAGTPVIKEGPDGVVFYTLPDIVVNMQTADGKSTFLKLKLTFELPDEETADELTPNLPRLQDMFQTFLRELRPEDLNGSQGTYQLRVELLRRVNLVAAPAKVNAVLIEEMLIN
What is the function of this protein?
Controls the rotational direction of flagella during chemotaxis.
What are the official names of this protein?
Flagellar FliL protein.
What is the protein family that this protein belongs to?
Belongs to the FliL family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Note=Distributed throughout the cell inner membrane and not just at the poles;.
Protein: SYS_CHLPB
Sequence: MLDINYIRQSPEEVAGMLKKRRQEEDCATLDELLEYDRQRRELVQETDALKALRNKVSKDIAVIKRTGQGSAEDLIREMKEVADRIAGMDETLGEIEKQMESILLSLPNKLHPDVPEGYSAEENHICKDPVAFDHALDFPLMDHLDLGNKLGILDFERGAKISGTGFPVYIGKGARLERALLNFMLDCHTENHGYTEVFPPFMVNEDSLRGTGQWPKFADQVYYMNEDNLYAIPTAEVPVTNLHRNEMLKDEELPISYAAYSACFRREAGSYGKDTRGFLRVHQFNKIEMVKFTRPEESYDALEKILQNAEAILNALRIPYRVLLLCSGDISAGATKCYDIEVWSPAEKKYLEASSCSNFEDYQARRANIRFKPAGSSKPTYVHTLNGSGLATSRLMVSLLENYQTAEGTIVVPEVLRKYTGFDLID
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_SINMW
Sequence: MSNDPTHQFLVNKIVSIDIGGIDFSFTNASLFMVATVGAAAGFLYLTTSQRGLIPTRMQSVSEMSYEFIASMLREGAGSQGMKFFPMVFSLFMFILTANLLGMVPYFFTVTSQIIVTFALAVFVIGTVILYGFYKHGFGFLKLFVPHGVPGALLPLVVAIEIISFLSRPISLSVRLFANMLAGHITLKVFAGFVASLSAFGALGIGGAILPLIMTVALTGLEFLVAFLQAYVFAVLTCMYLNDAVHPGSH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y626_HELPG
Sequence: MEKLPKKRVSKTKSQKLIHSLITQKNRAFLKKISANEMLLELEKGAFKKNEAYFISDEEDKNYVLVPDNVISLLAENARKAFEARLRAELERDIITQAPIDFEDVREVSLQLLENLRQKDGNLPNINTLNFVKQIKKEHPNLFFNFDNMFKQPPFNENNFENFDNSDEENF
What are the official names of this protein?
UPF0763 protein HPG27_626.
What is the protein family that this protein belongs to?
Belongs to the UPF0763 family.
Protein: RODZ_ECOL6
Sequence: MNTEATHDQNEALTTGARLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPADLASTFLRGYIRSYARLVHIPEEELLPGLEKQAPLRAAKVAPVQSFSLGKRRKKRDGWLMTFTWLVLFVVIGLSGAWWWQDHKAQQEEITTMADQSSAELNNNQSQSVPLDTSTTTDQAMATTPTSPVDTTATNTQTPAVTAPAPAVDPQQNAVVPPSQANVDTAATPAPAATTTPDGAAPLPTDQAGVTTPAVDPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEQSPAQ
What is the function of this protein?
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
What are the official names of this protein?
Cytoskeleton protein RodZ.
What is the protein family that this protein belongs to?
Belongs to the RodZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Forms helical filaments along the long axis of the cell.
Protein: SOML_ORYLA
Sequence: MHTKVLQQGLWALLLWPHLFTVSVPLDCRDDQASLARCPSISQEKLLDRVIHHAELIYRVSEESCSLFEEMFIPLPLRLQSNQGGYACITKALPIPSSKSEIQQLSDKWLLHSVLMLVQSWIEPLVYLQMTLDRYDHAPDMLLNKTKWVSEKLISLEQGVVVLIKKMLDEGAMTTTYSEQGAFQYDVQLEMLEYVMRDYTLLTCLKKDAHKMETFLKLLKCRQTDKYNCA
What is the function of this protein?
Selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells.
What are the official names of this protein?
Somatolactin, SL.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SEPT2_CHICK
Sequence: MSQSGEKVKFSDSAGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERYIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINSQDCFKTIIQYIDNQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVEFMKALHGKVNIVPVIAKADTLTLKERERLKRRVLDEISEHGIRIYQLPDADSDEDEEFKEQTRVLKASIPFAVIGSNQLIEVKGKKIRGRLYPWGVVEVENPEHNDFLKLRTMLVTHMQDLQEVTQDLHYENFRSERLKRTGKPVEEEVVDKDRILQQKEAELRRMQEMIAQMQAQMRMKPGDD
What is the function of this protein?
Filament-forming cytoskeletal GTPase.  Required for normal organization of the actin cytoskeleton.  Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin.  Required for the progression through mitosis.  Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression.  During anaphase, may be required for chromosome segregation and spindle elongation.  Plays a role in ciliogenesis and collective cell movements.  In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity).
What are the official names of this protein?
Septin-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane. Note=Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes.
Protein: QUEA_PROM3
Sequence: MVLDPRDSLLSSYDYPLDPERIAQLPVEPRHAARLLIVQPLGMKPPIARHAEVWDWQEELRAGDLLVINDTRVLKARLRVRRSGGGLAELLVLEPRGEGRWLCLGRPAKRLRPGDQLWLEALGEEPIALQVISKDSASGGRVVQFPSHYANAEQLELLLERYGEVPLPPYIKCHDPSDSERYQTRYASRPGAVAAPTAGLHLSDELLEALKQRGVMLTSVTLHVGLGTFRPVETEDLRHLQLHSEWVEVRDEVVAAVMACRARAGRVIAVGTTSVRALEGAALAGGGFLQSFCGPVDLVIQPGYRFAVVDGLLTNFHLPKSSLLLLVSAMVGRERLLALYAEAIEHHYRFFSYGDAMWIDPGAVLPAARPC
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB3_PEA
Sequence: MTASSSLFSCSMHMEVLTPKISKWPKDFVSCHSKISYVETNYLKSTCYPISRFLCINNLSKCDKMIKTRQRDGIHCFSEGQKFQLDDVIEAQQFDRDILNAIFEIARDMENIERNSPESQILKGYLMATLFYEPSTRTRLSFESAMRRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSDLIVLRHFESGAARRAAAIAGIPIVNAGDGPGQHPSQALLDVYTIEREIGKLDGIKVGLVGDLANGRTVRSLAYLLAKYKDVKIYFVSPEVVKMKDDIKDYLTSKGVDWEESSDLVEVASECDVVYQTRIQKERFGERLDLYEKARGKFIVNQNILNAMQRHAVIMHPLPRLDEITVDVDADPRAAYFRQAKYGLYIRMALLKLLLVGW
What are the official names of this protein?
Aspartate carbamoyltransferase 3, chloroplastic, Aspartate transcarbamylase 3, ATCase 3.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PER_DROWI
Sequence: NKDKSRKKKKPKCIALATATAVSLEGTRESPLPASGSCEKVLQELQDTQQLGEPLVVTETQLSEQLLETEQNEDQNKSEQLAQFPLPTPIVTTLSPGIGPGHDCVGGASGGAVAGGCLVVGAGTDKTSELIPGKLESAGTKPSQERPKEESFCCVISMHDGIVLYTTPSISDVLGFPRDMWLGRSFVDFVHHKDRATFASQITTGIPIAESRGCMPKDARSTFCVMLRRYRGLNSGGFGVIGRAVNYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKDTYETVMKKGQTAGASFCSKPYRFLIQNGCFVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKLCNVFETSVSAKPKISEEAQNRNARIKEDIVKLLAETVSRPSDTVKQEVSRRCQALANFMETLMDEITRADLKLDLPHENELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVESSYVSSARGEDARSTLSPVQGFEGSGGSGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGDGGGGGGADGTGSGAAPPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGDKNKKSANEAMKMLEYSGPGPGHGHGIKRGGSHSWEGEANKPKQQLTLNTGGGGGGGGGGGGGGGGGLPLFLDVTHTSSSSQNKGPTGVAAGGAGGGVGGGGGSCSGLGGNGNVGSGNGNNSQPSTNQYTQSGLPCTQNINLWPPFSVGITTPTSVLSSHTAVPPSSFSPQHSLFPTFYYIPASIAASSPSSTNTNPNRPHKHAHVHSSSEKPSTSQAAAATMPLQYMTGVMYPHPSLFYTHPAAAAATAMVYQPVPFAGVANPMQLPEQASKNVYTTQPVMVAPPTATNKTQGAFHSITPAPPQRPSSQATSVKAETGSNVAPSDTSKKEVPDSPITPTMGDFTLDQPCNNNATTLKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPENDKDAKHRKLKSLDQSDNKIVEHPEEDQTQHG
What is the function of this protein?
Essential for biological clock functions.  Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms.  Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system.  The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex.  Light induces the degradation of TIM, which promotes elimination of PER.  Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop.  Behaves as a negative element in circadian transcriptional loop.  Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
What are the official names of this protein?
Period circadian protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization (By similarity).
Protein: SCAF_HHV7J
Sequence: METVLVAGFLCVYDDNDINDNFYLPRRTIQEEINSGNGLNIPLNINHNENAVIGTVSSLSVYSTVCFVARVQSKEFLTIIKKIAAKSKLITNTEEKTLPPDPEIECLNSIFPGLSLSNRVGGNERDPFFKHVSICGVGRRPGTIAIFGRNLNWILDRFSSITEAEKEKILSTDQSCVQFFAEEQFKVDLYDLLADSLDTSYIKVRFPKLQSDKQLSGISKSTYIKASENLTANNHTINVNSKVTKETEATDSVSQDDCAVHAPDLISTICSTTHTTHHDLVRMNGSATGNSASLPAPQFSECVFLPKDTFCSLLNATAGAQNKNVTPAAPIFKTDEYITPYPESLSRVDYGNRMNYHIPPPYWYPSMPGFNYKSYRGSQKRCAPTDSDDEMSFPGDPDYTTKKKKRYREDDDRELTKDKNDIKELVDAIGMLRHEISALKYIRSQSPQRQHCTAVDTMPTIEEKNVASPKPSVVNASLTPGQDRNQNLMQSDQSLLSLNKKLFVEALNKMDN
What is the function of this protein?
Plays a major role in capsid assembly.  Acts as a scaffold protein by binding major capsid protein.  Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid.  Cleaved by assemblin after capsid completion.  The cleavages products are evicted from the capsid before or during DNA packaging.
What are the official names of this protein?
Capsid scaffolding protein, Capsid protein P40, Protease precursor, pPR.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae capsid scaffolding protein family.
What are the subcellular locations of this protein?
[Capsid scaffolding protein]: Host cytoplasm. SUBCELLULAR LOCATION: [Assemblin]: Host nucleus. SUBCELLULAR LOCATION: [Assembly protein]: Host nucleus.
Protein: DNAA_LEPBA
Sequence: MDIRWEEILEEISKQIPPKYFSNFIAPLRFDKWENQVVHLMAPSGGIKRHVETKYIGFIEDAVYQVVGDRFKVSILTESETSSHVLKEVIQSKFDDSDSDLNPEYIFSNYITSDSNRIAFTAAKSVVEQPGKYNPLYLFGPVGVGKTHLLHSIGNEIKKKDPWKTVRYVNSTSFLNEFIFTVRQNNRESLESFKIRYQSYNVLLFDDIQFLNGGAEKTQEEFFALFNFLYDRKRQIVIASDRPSYELPLHDRLKSRFVHGLQADIKSHDLELRKSLLKSNFSEFNIPASDNLLHWLAERLEGDSRALIGIVNDLVMYKKAYEYFLLTEDKIKEIAEARFLTNKKRIGFSPDMVIDLVCERTNVARKDLLGKSRKADFIPPRHLCMLLLHDVLNVPKAQIGRIFSTTHSTVIHGIDKFKERMKSEAQWEDLFHTIKHKISFQ
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSVB_DESVH
Sequence: MAFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF
What is the function of this protein?
Catalyzes the reduction of sulfite to sulfide.  This is the terminal oxidation reaction in sulfate respiration, a process catalyzed by the sulfate-reducing bacteria.
What are the official names of this protein?
Sulfite reductase, dissimilatory-type subunit beta, Desulfoviridin subunit beta, Dissimilatory sulfite reductase subunit beta, dSiR beta, Hydrogensulfite reductase subunit beta.
Protein: Y611_CHLTE
Sequence: MRIHDIDPDNRPRERFLRSGKESLSPAELLALILRSGTAGLNIIDTCNKLISEHGLERLADLSIQELQKTPGIGEAKAMQIAAIFELQRRLHFARNMNLKVKGARDVFEYMKGRIPDETKEHLFVLFLSTKNQILRHETITIGTLTASLIHPREIFKAAIRESAHSIILVHNHPSGDVQPSNADKQVTSILKKAGDLLQIELLDHVIVGNNDWFSFRDHALL
What are the official names of this protein?
UPF0758 protein CT0611.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: IPMK_MOUSE
Sequence: MAAEPPALRLRPPGSTGDSPPVPRLLGGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYTMVYAADCADAVLLELRKHLPKYYGVWSPPTAPNDVYLKLEDVTHKFNKPCIMDVKIGRKSYDPFASSEKIQQQVSKYPLMEEIGFLVLGMRVYHLHSDSYETQNQHYGRGLTKETLKEGVSKFFHNGFCLRKDAIAASIQKVEKILQWFENQKQLNFYASSLLFVYEGSSQPATTKANDRTLAGRFLSKGPLTDADGLECNNNFHLFGAPPNGMSVGKSLSKAYSRHRKLYAKKHQSQTSLKVETLEQDNGWRSMSQEHLNGNVLAQLEKVFYHLPAGRPEIPEAEVRMIDFAHVFPSNTVDEGYVYGLKHLIAVLRSILDS
What is the function of this protein?
Inositol phosphate kinase with a broad substrate specificity.  Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:15939867).  Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).  Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (By similarity).  Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6).  Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase.  Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity).  Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (PubMed:15939867).
What are the official names of this protein?
Inositol polyphosphate multikinase, Inositol 1,3,4,6-tetrakisphosphate 5-kinase.
What is the protein family that this protein belongs to?
Belongs to the inositol phosphokinase (IPK) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y009_RICBR
Sequence: MLADKKIVKVEVSKEHLKTLNEASTLLISCVDFRLIDETDKLMKQLGLEDDFDKVSLPGASLALVNEKYTHWGKTIEDTIEILQDLHNIKQIIFLDHRECGAYKKLIAEERLSTKEKETEAHTEILNKARKIIKEKFPQLKVYTFLMGLDGVIEQIYERHPADC
What are the official names of this protein?
Uncharacterized protein RBE_0009.