PharMolix/UniProtQA huggingface dataset:
Protein: ATG5_CANGA
Sequence: MGDSKELVWNGSINVQIKLDSRLLVDGVPEGRRLVNIRVPRESHIAIYTPLVLERLRNVLRSDIEELLPKVWYSYKDISLPWSIPFGTLFDIYNGAHKGISGSRDNYINVWKLNLVTDEKFPINVIPIIEGQDQLRKFMMQSWKQCCFILNGSSKRVMSLSLQDSLEVWEGVTERDYAKYSGVIKRILPRTPRRIPVAIHAANGGPIVQTTEPTLTDTSFSQAVEGIVKADFVVCQGIVMYLRDFSDTSLYDVYDKLHSIDGYLHLIANL
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy).  Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production.  Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function.  The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Autophagy protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATG5 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: ATP6_KLULA
Sequence: MLNLFITSPLDQFEIRVLMGFTSPLLDFSSLNFTTFSLYTIIVLFTVLGLNLLTTNNNKIIGSKWFVSQEAIYDTILNMVKGQIGGKLWGYYFPLVYTFFFFIFVSNLISMIPYSFALSAHLIFIVSLSSVIWLGATIIGLTKHGLVFFSLFVPGGTPLPLVPLLVLIELLSYFARAISLGLRLSSNVLSGHLLLIILGGLLFNLMSMSIITFVFGLIPGVGLLAIVVLEFAISVIQAYVWSILTSSYLKDVLYLH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane (By similarity).
What are the official names of this protein?
ATP synthase subunit a, ATP synthase subunit 6, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RUXGL_HUMAN
Sequence: MSKAHPPELKKFTDKKFSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQKNIGMVEIRGNSIIMLEALERV
What is the function of this protein?
Associated with snRNP U1, U2, U4/U6 and U5.
What are the official names of this protein?
Putative small nuclear ribonucleoprotein G-like protein 15.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUSB_AGARV
Sequence: MTRSKIRENVFKMLFRVEFHDKSELAEQMELLNDELTNPTDEERQYIDEKCSAIIEHMAELDALIDEKSTGWKTNRMAKVDLAIIRLAVYEIKFEDDIPTKVSINEAVELAKKYGADESGAFVNGVLAKFA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: KUP1_NOVAD
Sequence: MSDAVTDADGSSAQSHAQSAGHHAVQGHGGHSQGPLLKLAVGAIGVVFGDIGTSPLYALRDTFAGHHKLPLDLLHIYGIISLMFWSMMIIVTFKYVSVIMRADNKGEGGSLALLALINQHTDGKRWGRGIILLGVFATALFYGDSMITPAVSVMGAIEGVAVYRPDMHPLIVPLVVGILIGLFFIQSRGTEKVAAFFGPIMLVYFGTIAVLGALSIAEYPPVIAALSPHHAVTMFIADPWRGFLAMGAAVLAVTGAEALYADMGHFGRSPIRMSWLVFVLPALVLNYLGQASLLIRNPAALESPFYYLAPEWFQWPLLFIASCAAVIASQAVISGAFSVTQQAIQLGFIPRMTIKHTSTAAGQIFIPVINWALMIAVILLVLVFQRSSNLTAAYGIAVTGAMLIDNFLLAVVLFKLWQWKAPAAIAMLAVFFAIDAAYLGANMTKIPDGGWVPLVMGIAIFTLLTTWSRGRALMRENMAEGTIPLDVFTKSAHSSAARVSGTAIFMASTAAGVPSALLHNIKHNKVLHERVVILTVSIEDVPYVDEGERYSVKDFGNGFYRLTLRFGFLEETDVPGALKGVSMCGEPFNMMKTSFFLSRQTLIPSDKPGMALWREKLFAWMLRNAASAMEFFRLPTNRVVELGSQLKI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 1.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AP3S_SCHPO
Sequence: MIYAVFIFNNKGKPRLTKFYTPIDESIQQKLIGDIYAAVSTRPPTACNFLESNLIAGKNRIIYRQYATLYFVFVVDEGESELGILDLIQVFVEALDRCFNNVCELDLVFKFQEIHAILAEVVSGGLVLETNLNEIVLAAQNQMPKTKRSNAMPFSNTLSSFATRF
What is the function of this protein?
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated.  The complex is associated with the Golgi region as well as more peripheral structures.  It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).
What are the official names of this protein?
AP-3 complex subunit sigma, AP-3 complex sigma3A subunit, Adaptor-related protein complex 3 subunit sigma, Clathrin-associated/assembly/adaptor protein, small 3, Sigma-adaptin 3A, Sigma3-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: CF119_MOUSE
Sequence: MITPSSSQSLGMKVQMESEQSPKLQEELDRSPSSVDGSAIRNGTDMQTESPAEATSSPVEVAEDPGANLFPPPLPQPRICMWKYLDIHSMHRLEKAATVEKMREVLAELLELGFPEQSLRDAIILDLFSHALIFCRQQGFSPEQTSAACAMLQDLHKACVATPLGNVEECYRYFTSVLFCHGIRRPPFSIDLFKEEQLLALADYVVNTYFRHFKLYKYVFTPQVRLDLSLTYTGLQPLTLWPEEKENEEMMVVEQVATPQEEEPETVTEPEQQPSEVCILQTYIKSQLSKELRQLQQLVEERLKESEERLSSKLAALEQPFQTPPSKGKTKTK
What are the official names of this protein?
Cilia- and flagella-associated protein 119, Coiled-coil domain-containing protein 189.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm. Note=In elongated spermatids, enriched in the principal piece of flagella where it is peri-axonemal. Disappears from sperm heads upon acrosome reaction.
Protein: LUXN_VIBHA
Sequence: MFDFSLEAIVYAKAISLLATVAVVMMWLFYYCYRLKQKNEVIFGTHHAAYIAYSVCIIAWISSNAYFHTDLLPELGASAGMFMAKFANLASFFAFAFAYYFSCQLAAEQRKGKVHRWQQGIFVSLTVYSLFINLRPGLTVEHVDIVGPSQFIIEFGPHTSYFFIGLVSFVVLTLVNLVAMRTNSSKLTLAKTNYMIAGILVFMLSTAVIHLGMTYFMGDFSLTWLPPALSISEMLFVGYALLTSRFYSVKYIAYLALSVLLVCAIFVLPLGAIFIPLTESNQWLIAIPICALIGITWQLLYKKTSRYASFLIYGDKKTPVQQILSLEEDFKLSIDDAMRRLGKLLQIPNDKLRLVTSNYNETFYEEYLSSNRSVLVFDELSEELEYKVSAKRSMKALYDKMSSNNTALVMPLFGQGKSVTHLLISPHKSNNQMFSNEEISAVQTLLTRVQSTIEADRRIRQSRALANSIAHEMRNPLAQVQLQFEALKQHIENHAPVEQITLDIENGQAAIQRGRQLIDIILREVSDSSPEHEPIAMTSIHKAVDQAVSHYGFENEKIIERIRLPQHTDFVAKLNETLFNFVIFNLIRNAIYYFDSYPDSQIEISTKTGPYENTLIFRDTGPGIDETISHKIFDDFFSYQKSGGSGLGLGYCQRVMRSFGGRIECKSKLGTFTEFHLYFPVVPNAPKADTLRTPYFNDWKQNKRSNEHKVAPNVQINNQSPTVLIVDDKEVQRALVQMYLNQLGVNSLQANNGENAVEVFKANHVDLILMDVQMPVMNGFDASQRIKELSPQTPIVALSGESGERELDMINKLMDGRLEKPTTLNALRHVLGNWLNKNTASSACEAERE
What is the function of this protein?
At low cell density, in the absence of AI-1 (autoinducer 1), LuxN has a kinase activity and autophosphorylates on His-471.  The phosphoryl group is then transferred on Asp-771 of the response regulator domain.  The phosphoryl group is transferred to LuxU, and ultimately to LuxO.  At high cell density, in the presence of AI-1, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity.  LuxN phosphatase acts on itself.  As LuxU could function to establish an equilibrium between the aspartyl-phosphate of LuxN and the aspartyl-phosphate of LuxO, LuxU transfers phosphate from LuxO to LuxN and finally phosphate is drained from the system (By similarity).
What are the official names of this protein?
Autoinducer 1 sensor kinase/phosphatase LuxN.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPH_TOBAC
Sequence: MNPLISAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TSAD_HELPS
Sequence: MILSIESSCDDSSLALTRIKDAKLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNKDFSKIKAIAITNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKQTCMPLSALLVSGGHSLILEARDYEDIKIVATSLDDSFGESFDKVSKMLDLGYPGGPIVEKLALDYAHQNEPLMFPIPLKNSQNLAFSFSGLKNAVRLEVEKNAPNLNEAIKQKISYHFQSAAIEHLIQQTKRYFKIKRPKIFGIVGGASQNLALRKAFENLCDEFDCKLVLAPLEFCNDNAAMIGRSSLEAYQQKRFVPLEKANISPRTLLKSFE
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TALB_ECO57
Sequence: MTDKLTSLRQYTTVVADTGDIAAMKLYQPQDATTNPSLILNAAQIPEYRKLIDDAVAWAKQQSNDRAQQIVDATDKLAVNIGLEILKLVPGRISTEVDARLSYDTEASIAKAKRLIKLYNDAGISNDRILIKLASTWQGIRAAEQLEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRILDWYKANTDKKEYAPAEDPGVVSVSEIYQYYKEHGYETVVMGASFRNIGEILELAGCDRLTIAPALLKELAESEGAIERKLSYTGEVKARPARITESEFLWQHNQDPMAVDKLAEGIRKFAIDQEKLEKMIGDLL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase B.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METN2_YERPA
Sequence: MISIERLSKTYPQGGLPMVALEEVSLEIPTGSVFGIVGRSGAGKSTLIRCLNLLERPTSGRIQVDGRELTTLSDRELRLQRQNIGMIFQNFHLLHSRNVWDNIAVGLEIIGMPKAQRQQRVAELLDLVGLSDKAYAFPSQLSGGQKQRVGIARALAAKPSYLLSDEATSALDPETTASILALLSDINRQLGLTIVLITHELDVVKSICDNAALLETGRVVETGAIADLLSDPLSRLGRSLLPTCGPLSVSATPRAELTFFDTLAASPVLSALAQQHAVGVTLLGGGVEFIGGQRVGRLHVDFNRPEGGLNLAEVLQFLNDRGVRAELI
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATG4C_HUMAN
Sequence: MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVNGHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
What is the function of this protein?
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:21177865, PubMed:29458288, PubMed:30661429).  The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (PubMed:21177865).  Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity).  In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989).  Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989).  Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity (PubMed:29458288).  In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy (PubMed:33773106).
What are the official names of this protein?
Cysteine protease ATG4C, AUT-like 3 cysteine endopeptidase, Autophagy-related cysteine endopeptidase 3, Autophagin-3, Autophagy-related protein 4 homolog C, HsAPG4C.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VNFK_AZOPA
Sequence: MSNCELTVLKPAEVKLSPRDREGIINPMYDCQPAGAQYAGIGIKDCIPLVHGGQGCTMFVRLLFAQHFKENFDVASTSLHEESAVFGGAKRVEEGVLVLARRYPNLRVIPIITTCSTEVIGDDIEGSIRVCNRALEAEFPDRKIYLAPVHTPSFKGSHVTGYAECVKSVFKTITDAHGKGQPSGKLNVFPGWVNPGDVVLLKHYFKEMDVEANIYMDTEDFDSPMLPNKSIETHGRTTVEDIADSANALATLSLARYEGNTTGELLQKTFAVPNALVNTPYGIKNTDDMLRKIAEVTGKEIPESLVRERGIALDALADLAHMFFANKKVAIFGHPDLVLGLAQFCIEV
What is the function of this protein?
This vanadium-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
What are the official names of this protein?
Nitrogenase vanadium-iron protein beta chain, Dinitrogenase 2 subunit beta, Nitrogenase component I.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: YCIB_SALSV
Sequence: MKQFLDFLPLVVFFAFYKLYDIYAATSALIVATAIVLIYSWVRYRKIEKMALITFVLVAVFGGLTLFFHNDEFIKWKVTVIYALFAGALLISQWVMKKPLIQRMLGKELALPQQVWSKLNLAWALFFIACGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGVYIYRHLPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPD_MANSM
Sequence: MSELTTIARPYAKAAFDFAVEQSATDKSAVEKWTEMLGFAAQVADNEQIRDFFANTFSVQKAADAMVSICGEQLDQYGQNLIRLMAENKRLTVLPAVFDEFQRYVEEHNATAEVQVISAQPLNATQEQKIAAAMEKRLARKVKLNCSVDNSLLAGVIIRTDDFVIDGSSRGQLNRLANELQ
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: METK_STRPD
Sequence: MSERKLFTSESVSEGHPDKIADQISDAILDAILAEDPEAHVAAETCVYTGSVHVFGEISTTAYIDINRVVRDTIAEIGYTEAEYGFSAESVGVHPSLVEQSGDIAQGVNEALESREGDTDDLSHIGAGDQGLMFGFAINETPELMPLPISLSHQLVRRLAELRKSGEISYLRPDAKSQVTVEYDEHDKPVRVDTVVISTQHDPEATNDQICQDVIEKVIKAVIPADYLDDDTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNLVAAGLATKAEVQLAYAIGVAQPVSVRVDTFGTSTVPEAVLEAAVRQVFDLRPAGIIQMLDLKRPIYKQTAAYGHMGRTDIDLPWERLNKIDALVEAVKTVL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM2_STAAN
Sequence: MKFDRHRRLRSSATMRDMVRENHVRKEDLIYPIFVVEKDDVKKEIKSLPGVYQISLNLLESELKEAYDLGIRAIMFFGVPNSKDDIGTGAYIHDGVIQQATRIAKKMYDDLLIVADTCLCEYTDHGHCGVIDDHTHDVDNDKSLPLLVKTAISQVEAGADIIAPSNMMDGFVAEIRRGLDEAGYYNIPIMSYGVKYASSFFGPFRDAADSAPSFGDRKTYQMDPANRLEALRELESDLKEGCDMMIVKPALSYLDIVRDVKNHTNVPVVAYNVSGEYSMTKAAAQNGWIDEERVVMEQMVSMKRAGADMIITYFAKDICRYLDK
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: RR4_DRIGR
Sequence: MSRYRGPRFKKIRRLGALPGLTRKRPRSGSDLRNQSRSGKRSQYRIRLEEKQKLRFHYGLTERQLLRYVRIAGKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSYRCKPQDIITTRDEQRSRALIQNYMDSSPHEELAKHLSLYSSQYKGLVNQIIDIKWIGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLPX_EXISA
Sequence: MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIELCNEIVEEELGVEEEVEFKDIPKPQEIRNILDDYVIGQDRAKRALSVAVYNHYKRINAGGRSDDVELAKSNIVMIGPTGSGKTLLAQTMARVLNVPFAIADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNILFIVGGAFAGIESVVKRRIGKKVIGFGNDQENRELTQEDLLARALPEDLQKFGLIPEFIGRLPVMATLTTLDEEALVEILTKPKNALVRQYEKMLELDDVELTFTDEALIEIAKLAIKRKTGARGLRSIIEEMMLDVMFTVPSRDDIEKVIITDETITGLAGPKYVLRDGTVEQTGDNKETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: HST3_ECOLX
Sequence: MKKSILFIFLSVLSFSPFAQDAKPVESSKEKITLESKKCNIAKKSNKSGPESMNSSNYCCELCCNPACTGCY
What is the function of this protein?
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
What are the official names of this protein?
Heat-stable enterotoxin A3/A4, ST-H, ST-IB, STA3/STA4.
What is the protein family that this protein belongs to?
Belongs to the heat-stable enterotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: VAPC2_MYCTU
Sequence: MTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRALEVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Acts as an RNase.  Upon expression in M. smegmatis inhibits translation, growth and colony formation.  All its toxic effects are neutralized by coexpression with cognate antitoxin VapB2.
What are the official names of this protein?
Ribonuclease VapC2, RNase VapC2, Toxin VapC2.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: XANF_ASPFU
Sequence: MATEALHMHKDRLSAEDLDLKDPHVSSSLALFAIHNLIRRNLKACAEHAITVQPANIDAFVTYAKYTLHVLRDQLTSVDEIWFPVFAEHDPRFLAQKDAHDALYQRITAVDAQLATPPAELGQNELLSAEIAAAFAELHELTDKQYDLEEDLINQLGRKVPMDTIRGLEKKQEERRRADVKVYGHLWTAVYLLRGLDPKERAIFPPGIPKLIAGGMLTAGAMQFRR
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives (PubMed:29844112).  The first step of the pathway consists in the conversion of tyrosine into a vinyl-isonitrile intermediate by the isocyanide synthase xanB (PubMed:29844112).  Subsequent oxidative dimerization of this intermediate to form xanthocillin may involve the cytochrome P450 monooxygenase xanG, whose expression is coregulated with that of XanB (PubMed:29844112).  Xanthocillin can be further modified by the isonitrile hydratase-like protein xanA which introduces N-formyl groups and the methyltransferase xanE which introduces methyl groups, leading to the production of several derivatives including fumiformamide (PubMed:29844112).  Finally, fumiformamide can be subject to both oxidative and reductive cyclization to yield melanocins E and F, respectively (PubMed:29844112).
What are the official names of this protein?
Xanthocillin biosynthesis cluster protein F.
Protein: RLMCD_BACSU
Sequence: MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEEKAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQKQVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDIIDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIVFITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLIGDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAKKVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRKGCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVECCVLIKLKE
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at positions 747 (m5U747) and 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil-C(5))-methyltransferase RlmCD, 23S rRNA (uracil(1939)-C(5))-methyltransferase, 23S rRNA (uracil(747)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: COBQ_PROM1
Sequence: MVLGTSSGAGKTLIATAICRCLRRKGEQPIPFKGQNMSNNAWVDTQGREMAYSQALQSWSAGLEPSAEMNPVLLKPKGDCTSEVIHLGKSVGTSKAINYYEDWFDSGWEAIKKGLAILLKSKIDGRLILEGAGSPVEVNLQHKDLTNLKLAKFLNANCILVADIERGGVFAQIIGTIALMKPDEKKLIKGIIINRFRGDKALFESGVTWIEKETGIPVLGILPWLKEIFPPEDSLDLLERKQVNKSAEIEIAIIKLPRISNFSDLDPFFSDSSIQMRWIEPGQDLGNPDVLIIPGSKQTIKDLESLNKTGLSNQIKNYAKKGGNIFGICGGLQMLGKTLEDPHKQESIKEQNTFSNMGMNLLPIKTTFGEIKHTSQREEKVSWPVSQSLKGFEMHYGESDLINNTDSEIISLFKNSSLGWVIEKKDKSFVGGTYLHGIFENDEWRRQWINKIRQKKGLNHLKIDKENNNDKRERLLDLLTDAFEKNINIDILIK
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.