PharMolix/UniProtQA huggingface dataset:
Protein: LIPA_CHLAB
Sequence: MNDTPNDIQKPKQGKRFSERLPHWLRQALPKGSVFDFTDKTIKRTGMATVCEEALCPNRTRCWSRKTATYLALGDACSRRCGFCNIDFTKKPLPPDPDEPRKIAESAKILQLKHIVLTMVARDDLEDGGASCLVRIIDTLHKELPESTVEMLASDFQGNVDALHTLLDSGLTIYNHNVETVERLTPVVRHKATYRRSLFMLEQAALYLPDLKIKSGIMVGLGEQESEVKQTLKDLADHGVRIVTIGQYLRPSRLHIPVKSYVTPETFDYYRRVGESLGLFVYAGPFVRSSFNADIVLQDMENKQSKMAKT
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_HELAH
Sequence: MRCFKATIAYDGAYFLGYAKQPDKLGVQDKIESALNLLGIKSVVIAAGRTDKGVHANNQVLSFHAQKHWSADKLFYYLAPKLAPHIVLKKLEEKNFHARFDAQKRAYRYLLTKSLKTPFLAPYIACGDYGSLDSLNTALKQFIGKHDFSMFKKEGGAATNPKRIIFNAFAYKASIMGHECVVFKIIGDAFLRSSVRLIMQACVQYSLEKITLAEIKTQINNIKATIRTPIMANGLYLHRVHY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: RUVC_CAUSK
Sequence: MMNANRIPIRILGLDPGLRRTGWGVVSVEGSRMSHVAHGVIVPDEKGEFASRLLCLFEGICAVIDAHRPDEAAVEEVFLNTNAQSTLKLGHARAAALIAPARAGLLVAEYSTRLVKKAVVGTGAADKAQIGFMIARLLPTAGKTTADCADALAVAITHANLRIANRRVA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RL36_CAMJ8
Sequence: MKVRPSVKKMCDKCKVVRRKGVVRIICENPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: COAD_METI4
Sequence: MKRVLYPGTFDPITLGHVDVISKAARLFDEVVVGVAAQTPKETLFELEERMELVERTLKHFSFSNAIALPYTGLTVDFAKELNCCAIIRGLRAVSDFETEFQLALMNRRLKPEIETLFLMPEDNHIYLSSSLVKEISRLGGEISAFVPTVVMEALKQKIGKRNSNPVAISRPR
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_BACC2
Sequence: MQKMTIKEAENVLKEIMNEEDDRFQLLMKDERKGVQKLVLKWYKQKELEQKEKENFFEMSKYENALREKGVTYIAGIDEVGRGPLAGPVVTAAVVLPEDFYIPGLNDSKKLSEAKRERFYDEIKVQAIAIGVGIVSPQVIDDINIYQATKQAMLDAVANLSCTPQHLLIDAMKLPTPIPQTSIIKGDAKSISISAASIIAKVTRDRMMKELGEKYPEYGFEQHMGYGTKQHLEAIEVHGVLDEHRKSFAPIKDMIQK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_LACGA
Sequence: MKVALVYNEKVETLAVVKALEKLLDSRKIEIDPENPDVVITIGGDGTLISGFHKYQNLVDQIRFIGVHTGHLGFYTDWRNFEIGKMVDNLTKKQPSSASYPLLELIITTGSGEKKKLLALNEATIKRVSKTLKADVYIRDQFFESFKGDGLCVSTPTGSTAYSKSLGGAVIHPRLKALQMTEIASINNRVFRTLSSPIVIAPDEWITIKPESDDHYVVTYDGYEFNHKHIKKIEYRISQHVIRFDKYQHTHFWNRVEDAFIGQPKNK
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_STAAS
Sequence: MAAIKPITTYKGKIVPLFNDNIDTDQIIPKVHLKRISKSGFGPFAFDEWRYLPDGSDNPDFNPNKPQYKGASILITGDNFGCGSSREHAAWALKDYGFHIIIAGSFSDIFYMNCTKNAMLPIVLEKNAREHLAKYVEIEVDLPNQTVSSPDKRFHFEIDETWKNKLVNGLDDIAITLQYESLIEKYEKSL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: YAO4_SCHPO
Sequence: MSQDSESFIRQLFKAFTDFSTDVESLRGFLTPDYRQLVDGRELTLDDFISHAKALRTHLHRLDINVQQIVCQGNKAATVHIAHAIRSSGESSRIKVIAFYSFKDGRISLIDELTYVLEGGNADRELGSVQ
What are the official names of this protein?
Uncharacterized protein C11D3.04c.
Protein: HOPP_HALSX
Sequence: MKKTLLATAIAGAMAASGAQAATVYNQDGTKLDIYGNVQIGFRNIEAENDNGNIETQNDVFDNGSTIGFAAEHVIYDGLTGYMKIEFDDFKADEMKTAGRDAGDTAYVGLKGNFGDVKLGSYDTLMDDWIQDPITNNEYFDVSDTSGSGSSVVAVGGEVETDQLTYVSPSFNGLELAIGTQYKGDMEEENVTSRGNASVFGGAKYTAGNFSVAATYDNLDNYEVTQTGVDNKQEFGDRYGVTGQYQWNSLRVALKYERFDSDLDNVDSVNFYGLGARYGYGYGDIYGAYQYVDVGGDTFGNVVDDATSGDSPSDTASDRGDDTYNEFIIGGTYNISDAMYTWVEAAFYDREDDEGDGVAAGVTYMF
What is the function of this protein?
Outer membrane porin that allows diffusion of monosaccharides.  Also allows diffusion of disaccharides and trisaccharides, with reduced diffusion rate.
What are the official names of this protein?
Monosaccharide porin, Major outer membrane protein HopP.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: WNT11_HUMAN
Sequence: MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters.
What are the official names of this protein?
Protein Wnt-11.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: YIDD_HELPS
Sequence: MRNNKTPFLSAIFTALIRGYQRFFSAFTFSSCRFYPTCSNYALWLLYFENPLSAMGKIAIRILSCNPFCSGGIAYPTTRLKRPSLLQSHKDFNRNFKTITFWLVPTTKSHATYYIIKV
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SDCB1_HUMAN
Sequence: MSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLSLNEEEIRANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV
What is the function of this protein?
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527).  Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types.  May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292).  In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).  Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120).  In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components.  Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591).  May also play a role in vesicular trafficking (PubMed:11179419).  Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
What are the official names of this protein?
Syntenin-1, Melanoma differentiation-associated protein 9, MDA-9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, TACIP18, Scaffold protein Pbp1, Syndecan-binding protein 1.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Secreted, extracellular exosome. Membrane raft. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966).
Protein: SCE1_YEAST
Sequence: MKNIKKNQVMNLGPNSKLLKEYKSQLIELNIEQFEAGIGLILGDAYIRSRDEGKTYCMQFEWKNKAYMDHVCLLYDQWVLSPPHKKERVNHLGNLVITWGAQTFKHQAFNKLANLFIVNNKKTIPNNLVENYLTPMSLAYWFMDDGGKWDYNKNSTNKSIVLNTQSFTFEEVEYLVKGLRNKFQLNCYVKINKNKPIIYIDSMSYLIFYNLIKPYLIPQMMYKLPNTISSETFLK
What is the function of this protein?
Mitochondrial DNA endonuclease involved in intron homing.  It introduces a specific double-strand break in the DNA of the 21S rRNA gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene.  Specifically recognizes and cleaves the sequence 5'-TAGGGATAACAGGGTAAT-3'.
What are the official names of this protein?
Intron-encoded endonuclease I-SceI, 21S rRNA intron maturase, Homing endonuclease omega.
What is the protein family that this protein belongs to?
Belongs to the LAGLIDADG endonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PFKA_HISS2
Sequence: MIKKIAVLTSGGDAPGMNAAIRGVVRSALSEGLEVYGIYEGYYGLYHNKIQQLTRYSVSDIINRGGTFLGSARFPEFKDPAVREKCVEILRSHGIDALVVIGGDGSYMGAKLLTEEHDFPCVGIPGTIDNDVAGTDYTIGYQTALETAVEAIDRLRDTSSSHKRISIVEIMGRHCSDLTISAAIAGGCEYIVASEIEFNREELIKQIERAIIKGKRHAIIAITELLCDVNELAREIEARVKHETRATILGHIQRGGTPCAFDRILGSRMGVYAVDLLLQGKGGYCVGIQNEQLVHHDIIDAINNMRREFKADWLAMSKRLD
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_BURM1
Sequence: MDYLDLGPYSSASGTVRLPGSKSISNRVLLLAALAEGDTTITNLLDSDDTRVMLDALGKLGVKLARDGDTCVVTGTRGAFTAKTADLFLGNAGTAVRPLTAALAINGGDYRVHGVPRMHERPIGDLVDGLRQIGAQIDYEQNEGFPPLRIRPATISVDAPIRVRGDVSSQFLTALLMTLPLVKAKDGRSIVEIDGELISKPYIDITIRLMARFGVNVEREGWQRFTVPAGVRYRSPGRIMVEGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFAHALMQMGANVTMGDDWIEVRGIGHDHGKLEPIDMDFNLIPDAAMTIAVAALFANGTSTLRNIASWRVKETDRIAAMATELRKVGATVEEGADYLVVTPPAALTPNAAIDTYDDHRMAMCFSLVSLGGVPVRINDPKCVGKTFPDYFDRFAALAKA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF70_WHEAT
Sequence: MALILYAIFYLFLVLLNFFHSFKQESNKLELSQWKKGERGKC
What are the official names of this protein?
Uncharacterized protein ycf70, ORF42.
What is the protein family that this protein belongs to?
Belongs to the ycf70 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NTPP_HELPS
Sequence: MELILGSQSSARANLLKEHGIEFEQKALYFDEESLKTTDPREFVYLACKGKLEKAKELLANNRTIVVADSVVSVGNRMQRKAKNRQEAFEFLKRQNGHEIEVLTCSALISPALEWLDLSVFRARLKAFDPSEMEKYLESGLWQESAGCVRLEDFHKPYIKSLSENLSVGLGLNVEGLLGVLKLGAKLSSL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBF_BIGNA
Sequence: MTIKNKTINLIENKKPVVYPIFTFRWLAVHALAVPTVFFIGSITSMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: TM177_DANRE
Sequence: MSSRFLKISVFIQKYRTPLLLIGCGGVFSANIFYHIFPDHTYKKVYQAWHKGEPASLSEKLQNIFQEVLKDSSISTSGNFSAFAAFGFHPVGAGVPWLPSGAQIGIPANFNSSTADLEGITNRTILINGKELEWDSDSGVALKNSLVFSLEAQKFAIAREVARLGSGGPILHAAVAPVCLAGACVYSVALKQIFRFQAGSIIFRGVVNLLSLGLGVMTYVLAADSVSQWLDYRSDRRAAGLSRDYAKGGLEFYEKILTRNKTLRSLMGQKGEEMYAPSGNLFPAHLLQLRHATYTSRRDRILNLLKNENV
What is the function of this protein?
Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.
What are the official names of this protein?
Transmembrane protein 177.
What is the protein family that this protein belongs to?
Belongs to the TMEM177 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SYV_SACS2
Sequence: MLFSLRNFISYSNLYLYKNVCIGGQLLLNQDEILKKMEEWPKHYNPKEIEEKWQKIWLSEEYWRDVFRFRDEDDKAPRFVIDTPPPFTSGELHMGHAYWVTIADTIGRFKRLEGYNVLLPQGWDTQGLPTELKVQYKLGIPKDNRQLFLQKCIEWTEEMIKKMKEAMIRLGYRPEWERFEYKTYEPKYRKIIQKSLIDMYKMNLIEMREGPVIWCPKCETALAQSEVGYLEKEGILAYIKFPLKEGGEIVIATTRPELLAATQAIAVNPMDERYKNLVGKIALVPIFNIEVKIISDADVEKEFGTGAVMISTYGDPQDIKWQLKYNLPIKVIVDEKGRIINTNGILDGLKIEQARNKMIELLKTKGYLVKVEKIKHNVLSHVERSDCLSPVEFLVKKQIYIKVLDKKQKLLEEYKKMKFKPARMSYYLEDWIKSIEWDWNITRQRIYGTPLPFWYCENGHLVPAKEEDLPIDPIKTSPPLEKCPLCGSELKPVTDVADVWIDSSVTVLYLTKFYEDKNVFNRTFPASLRLQGTDIIRTWLFYTFFRTLMLANNVPFTTVLVNGQVLGPDGTRMSKSKGNVVSPLDRVNDFGADAIRMALLDASIGDDFPFKWDIVKGKKMLLQKLWNASRLVYPFIAKQRLDKPKSLHIVDKWILQEHKKFVTKAINAYENYDFYLVLQELYNYFWEIVADEYLEMIKHRLFDDDNSAKYTIQRIIRDIIILLHPIAPHITEEIYSRLFGHKKSVLLEELPKVDDIEENKRIDELGEVIKKTNSLIRSEKIKNRLSMNTPVSVKLYASKQVIELINEVKDDVMKTLKVTNLELIESNEEKVEIKTANQSMGV
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNC_PARXL
Sequence: MDAIREAIRIERLSKTFSNGRKALDEIDLRIEPGEMVALIGASGSGKSTLLRHIAGFTASDAQPSQIEILGRPIQQNGRIVREVRSIRRDIGFVFQQFNLVNRLSVETNVLIGALARLPWWRRLSGRFPRAERALSIAALNEVGIGEHARERAANLSGGQQQRAALARALVQRARIVLADEPIASLDPESSRRVMDMLRTLNIEHRLTVLVSLHQVEIAMQYCPRTIALRRGKVVYDGPSAALTPALLKTLYGDEARELIDEAAQGPDDTESKNTADNTPLQDAAPASGRYAFALNPAHSN
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DEOB_STRP3
Sequence: MSKFNRIHLVVLDSVGIGAAPDADKFFNAGVADTDSDTLGHISEAAGLSVPNMAKIGLGNISRPIPLKTVPTEDNPTGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPRQMETGELIVYTSADPVLQIAAHEDIIPVEELYKICEYARSITLERPALLGRIIARPYVGDPGNFTRTANRHDYAVSPFQDTVLNKLADAGVPTYAVGKINDIFNGSGITNDMGHNKSNSHGIDTLIKTLQLPEFTKGFSFTNLVDFDANFGHRRDPEGYRDCLHEFDNRLPEIIANMKEDDLLLITADHGNDPTYAGTDHTREYIPLLAYSVSFTGNGLIPQGHFADISATVAENFGVDTAMIGESFLSHLK
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOIPA_XENLA
Sequence: MATSISTQRGQVFIGELPQDFLRIAPTQQQQQIQLDAQAAQQLQYSGVMGTMGRLSITVVQAKLAKNYGMTRMDPYCRIRLGYAVYETPTAHNGAKNPRWNKVIQCTIPPGVDSFYLEIFDERAFSMDDRIAWTHITIPETLKEGKHVDEWFSLSGRQGDDKEGMINLVMSYTSVPAMMPAQPVVLMPTVYQQGVGYVPIAGPVYNPGMPMIASPPAVNPQHQTQEVDIQSIKDMFPTIDPEVIRSVLEAQGGNRDAAINSLLQMVEDS
What is the function of this protein?
Component of the signaling pathway of IL-1 and Toll-like receptors.  Inhibits cell activation by microbial products.  Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates.  The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
What are the official names of this protein?
Toll-interacting protein A.
What is the protein family that this protein belongs to?
Belongs to the tollip family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDM4_ARATH
Sequence: MDGVGESSTQNEVEEKPVIVRVKRKVGQSLLDAFWLEINERPLKRPTLDFSKLSISDSGERGPSVAEDVKPKKVLVRHLETVTDSETTADIIHSFFESDHNEKSCSKGKFEERKIAFKKDNRKEQRLTKSVQKQQIASENARFEQIWRSRKGNKEGIHEKCHFFDVIRVDTEERRDNAQEFTSLEDQKMLASFLPLLRECIPTAAEEIEADIQSSHTEEYVYDYYAVNEEMDISEDSSKNQFPLVIVEDEEEFCDGSDESDYDSEDSNAEDHPKTDYPEEEEEEEEEDDDDDDDDESEEEKSEASDESDDEETSKRHVRSVLGDDEFDDYAEDVYGYSESDEEFES
What is the function of this protein?
Probable regulatory factor for several RNA polymerases.  Effector involved in facilitation of Pol V transcription as RNA scaffold and recruitment of silencing complex to target genomic sites.
What are the official names of this protein?
RNA-directed DNA methylation 4, Protein DEFECTIVE IN MERISTEM SILENCING 4.
What is the protein family that this protein belongs to?
Belongs to the IWR1/SLC7A6OS family.
Protein: HTPG_METPP
Sequence: MNKQTLSFQAEVQQLLHLVTHSLYSNKEIFLRELISNASDACDKLRFEALNDAALYEDASTLEVRVSFDKEARTITIADNGIGMSADEVIANLGTIAKSGTREFVGKLSGEQAKDAQLIGQFGVGFYSGYIVADRITVESRRAGLKAEEGVRWSSAGTGDFEVENLVRAQRGTSVTLHLRDGEDEFLSAWKLKSVIGRYSDHISLPILMRGQVWDAEKSEYVTQDAWETVNKAAALWARPKSEITDAEYKSFYEQFSHDSTPPLAYTHNRVEGRSEYIQLLYLPAKAPHDLWNRDRQGGIKLYVKRVFIMDDAQALMPSYLRFVKGVIDSSDLPLNVSRELLQESRDVKAIREGSTKRVLGMLEEMAGSEDAARRDQYAAFWREFGAVLKEGVGEDHANRERLAKLLRFASTQADEGVSLADYLARMKDGQEAIYYITADTTAAARHSPQLEVFRKKGIEVLLLTDRVDEWMLSHLFEFEGKPLQSVAKGAVDLGKLQDEGEKQQAEAAAEAFKPVLEKLKDTLKERAKDVRVTTRLVDSPACLVVEDGDISGHLARLLKQAGQSAPTSLPILEVNTEHALVKRLDGSERFDDLAQVLFDQAVLAEGGQLDDPAAYVQRVNRLLV
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNA12_MOUSE
Sequence: MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:19151758, PubMed:21212405, PubMed:22609986).  Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity).  GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (PubMed:19151758, PubMed:21212405).  GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity).  Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (By similarity).  Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity).  Together with NAPA promotes CDH5 localization to plasma membrane (By similarity).  May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
What are the official names of this protein?
Guanine nucleotide-binding protein subunit alpha-12, G alpha-12, G-protein subunit alpha-12.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(12) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Lateral cell membrane; Lipid-anchor. Cytoplasm. Note=CDH1 enhances cell membrane localization.