PharMolix/UniProtQA huggingface dataset:
Protein: HIS6_BURPS
Sequence: MALAKRIIPCLDVTAGRVVKGVNFVELRDAGDPVEIARRYDAQGADELTFLDITATSDGRDLILPIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVSMNSSAVANPPLVRDAADKYGSQCIVVAIDAKRVSADGEPPRWEVFTHGGRKGTGLDAVEWARKMAELGAGEILLTSMDRDGTKAGFDLALTRAVSDAVPVPVIASGGVGSLEHLAAGITEGHADAVLAASIFHYGEHTVGEAKRFMAERGIAVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA_CHRSD
Sequence: MHELTGKDKLAFNKLQKRLRRQVGNAIVDYGMIRDGDKVMVCLSGGKDSYTMLDILMNLQRNAPVAFELVAVNLDQKQPGFPEHVLPEYLERVGVPYHIVERDTYSVVKEKTPEGKTTCALCSRLRRGTLYGFAEEIGANKVALGHHREDMLETLFLNMFFGGSLKSMPPKLLSDDGKHIVIRPLAYCREADIAEYAEWREFPIIPCNLCGSQPNLQRQVVKEMLTEWEEKHPGRLETMFKAITNVAPSQLADRAMFDFEGLEDKQRDFLARRIETFDVLAREA
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_SYNS3
Sequence: MSRRNAAVKRPILPDPQFNNRLATMMVARLMKHGKKSTAQRILSDAFGMIGERTGGDPVELFETAVKNATPLVEVRARRVGGATYQVPMEVRQERGTAMALRWLVNFSRARNGRSMAQKLAGELMDAANEAGSAVRKREETHKMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SECA_BURP0
Sequence: MTTGFLQKIFGSRNQRLVKQYQKTVAAINALETQIETLTDDQLRGKTGEFRQRIAAGESLDKLLPEAFAVCREASRRVLKMRHFDVQMIGGMVLHYGKIAEMRTGEGKTLVATLAAYLNALAGRGVHVVTVNDYLAQRDAEWMGRLYNFLGLSVGINLSGMEHDQKQAAYAADITYGTNNEFGFDYLRDNMVYETDSRVQRPLNFAVVDEVDSILIDEARTPLIISGQAEDHTELYVRMNALPPLLERQIGEEKADGTGVEKPGDYTLDEKGRQVFLTESGHEKAERMLAEWGLIGDGESLYAPQNITLMHHVYAALRAHTLFHRDQHYVVQNDEVIIVDEFTGRLMPGRRWSDGLHQAVEAKEHVKIQSENQTLASITFQNYFRMYAKLSGMTGTADTEAYEFNEIYGLETVVIPTNRPPKRIDKQDQIYKTAKERYDAVIRDIRECHERGQPVLVGTTSIENSELLSHLLKQAGLPHEVLNAKQHAREAAIVAEAGRPKRITIATNMAGRGTDIVLGGNVEKQAAFIEADESIPADEKARRIQQLHDEWETLHEQVKTAGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDPLLRIFAGDRVRAIMDRLKMPEGEAIEAGIVTRSIESAQRKVEARNFDIRKQLLEYDDVSNDQRKVIYQQRNELLEAHDIAETIGAMRHGVISEVVRQFVPAGSIEEQWDLPELEETLRNDWQLDLAIQEMVNESSSINADEILDAVTTAADEHYEAKVALVGRESFSAFERSIMLQTLDRLWREHLAALDHLRQGIHLRGYAQKNPKQEYKREAFELFAAMLDAVKQEVTRIVMNVQIQSPEQLEEAAEQIEEQGGQLGNVEFQHADFAAAAAAATAGGAVVADATAEMVSHAMSHSGPAGEVPRVGRNDPCPCGSGKKYKHCHGKLN
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ROF_ECOLI
Sequence: MNDTYQPINCDDYDNLELACQHHLMLTLELKDGEKLQAKASDLVSRKNVEYLVVEAAGETRELRLDKITSFSHPEIGTVVVSES
What is the function of this protein?
Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination.
What are the official names of this protein?
Protein rof.
Protein: LSR2_MYCLE
Sequence: MAKKVTVTLVDDFDGAGAADETVEFGLDGVTYEIDLTNKNAAKLRGDLRQWVSAGRRVGGRRRGRSNSGRGRGAIDREQSAAIREWARRNGHNVSTRGRIPADVIDAFHAAT
What is the function of this protein?
DNA-bridging protein that has both architectural and regulatory roles.  Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments.  Represses expression of multiple genes involved in a broad range of cellular processes.  May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels.  Protects against reactive oxygen intermediates (By similarity).  Dominant T-cell antigen and stimulates lymphoproliferation.  Most probably causes the lymphoproliferative responses occurring in leprosy.
What are the official names of this protein?
Nucleoid-associated protein Lsr2, 15 kDa antigen, A15.
What is the protein family that this protein belongs to?
Belongs to the Lsr2 family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: GLMU_SALPA
Sequence: MLNSAMSVVILAAGKGTRMYSDIPKVLHTLAGKPMVQHVIDAATKLGAAQVHLVYGHGGELLKQTLKDDKLNWVLQAEQLGTGHAMQQAAPFFSDDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPSGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADLKRWLSKLTNNNAQGEYYITDIIALAYQEGREIAAVHPARISETDGVNNRLQLSRLERIYQAEQAEKLLLSGVMLRDPARFDLRGTLHCGMDVEIDANVIIEGYVTLGHRVKIGAGCIIKNSVIGDDCEISPYSVVEDAHLEAACTIGPFARLRPGAELLAGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTVIDDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVADNELVLSRVPQVHKQGWQRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAR3L_MOUSE
Sequence: MKVTVCFGRTGIVVPCKDGQLRVRELTQQALQRYLKTRDQDPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFDEQEPLQKTESPGGNPADRQSPDAFETEVAAQLAAFKPVGGEIVVTPSALKLGTPLLVRRSSDPAPGPHADAQPSTASLSGQSLKPVVLDSTQNVENKEAMNGEQAGLLSLHRPKDELSDMTRAVEISGEGDPLGIHVVPFFSSLSGRILGLFIRGIEENSRCKQEGLFQENECIVKINNVELLDKTFAQAQDVFRQAMKSPSVILHVLLPQNREQYEKSVIGPLNIFGNNDGASRTKAAPPARGKPGLKAVHLTRASSPEGEEPASPQQSKSPRVPRLGRKPSSPSLSPLMGFGSKKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAVKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETVSLVIARQEGSFLPRELKGEPDCYALSLESSEQLTLEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGETLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPLEELSECGALSRPGFENCQEALSTSRRNDSSILYPFGTYSPQDKRKDLLLPSDGWAENEVPPSPPPHPALEWGLEDFSHSSGVDSTGYFPDQHVNFRTVTPVRQPELINLKASKSMDLVPDEGKVQSLADRRSDSPGKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEADADGLSDKSSRSGHTALNCESAPQGNPELDNVENKAKNIKKTKEKEKKKGKGKLKVKEKKLKEEHEDAERKMKRKGFGAMLRFGKKKDDKVGKAEQKGAQKSGHPEEEELERMKEERERIGAKHQELREKQARGLVDYATAVTGPVHDMDDDEMDPNYARVNHFREPCASANVFRSPSPLRAGPLAYPRDGRPLSPDHLEGLYAKVNKPYHPPALADSGRPMAGTTDRIQKLRKEYYQARREGFLLYEDENTRARPSDHDLRWVSGKGPDGSTHNLRFEGMERQYASLPRGGSADPVDYLTASPRGRYNDRELPYYPGPHPVHAPRGSYPRPPDLRATDLRYPQYYPPPPAHQHKGPFRQDVPPSPPQHQRVPVYQEMGRAGPRGSSPDQYPYRNQDPRQKNPMTAAV
What is the function of this protein?
Putative adapter protein involved in asymmetrical cell division and cell polarization processes.  May play a role in the formation of epithelial tight junctions (By similarity).
What are the official names of this protein?
Partitioning defective 3 homolog B, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog, PAR3-beta, Partitioning defective 3-like protein, PAR3-L protein.
What is the protein family that this protein belongs to?
Belongs to the PAR3 family.
What are the subcellular locations of this protein?
Endomembrane system. Cell junction. Cell junction, tight junction. Note=Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions (By similarity).
Protein: MTH3_DROME
Sequence: MRIVIGSFTAFLLLLLQNSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSFKDDSIRIAPHFCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVLNVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQGTVIFLLFVLRPSTLKLLKERIKGGRDEAGASDEHISLQNTKIDPSVF
What are the official names of this protein?
Probable G-protein coupled receptor Mth-like 3, Protein methuselah-like 3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FGF1_MESAU
Sequence: MAEGEITTFSALTERFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESAGEVYIKGTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYTSKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD
What is the function of this protein?
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration.  Functions as potent mitogen in vitro.  Acts as a ligand for FGFR1 and integrins.  Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades.  Binds to integrin ITGAV:ITGB3.  Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling.  Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1.  Can induce angiogenesis.
What are the official names of this protein?
Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, aFGF, Heparin-binding growth factor 1, HBGF-1.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 (By similarity).
Protein: NPS6_COCMI
Sequence: MSRHQAVLQLHFFASILETLLKDVNHPLSHFDKVSEDELDELWSWNTPLQPELRFCMHEKVSERAALHPEKIAIDAWDGTLTYGQIEDYSDKLAKLLRLLDDSSNRIIPVLFEKSRWTSVAVLAIMKSGACFALLDPAQPEGRLRAVVQQVNAKIFLSSKAQSTLAARVAPAATIIPISKSKFNKIFSPYTAEQPNTTLPPVSPDQPLYIQFTSGSTGVPKGCILTHSQYTSGAIPRAAAVGYYPHSRVLDFASYAFDVCIDSMLCTLAHGATLCTPSDERRMNDMSGAMRDMRVTFAGMTPSVARTLDVDILNNLESIALGGEGVSISDAMSWGQRTRVVNAYGPSEATVGATINDNVAAKPYITMGQRKGCALWLTEPEDHNKLVPVGAVGELLIEGPIVGNGYLNNPSKTKEVFIEDPEFLIKGSKSYPGRHGRIYKTGDLVRFDPDGDGEPIFVGRQDQQVKLRGQRIELAEIEFNMQKHLPPDTQLAAEVIKPSGGGEQTLVAFLVEQKKNGMRHLDGNVFGSFTNKFQSALRDMTKQLFVDLPSYMVPSAYIPLWKMPLLVSCKTDRKRLREIGASVTRQDLRRFNSAVSEKKEATTEMELKLQSLWAKVLGGDADFSANDNFFSMGGDSLRAMRLVAAARDEAIVLSVPDIMLNPTLSAMAEKAKPVSAEETNEVPPFSMIGKDWDADAARRESARLCGVDAANVEDVYPCTPLQEGLIALSAKFQDAYVAQRVATLPAKTALRLKEAFDTAVEGSPVLRTRIVNVTGRGLFQVVLKDGQLVREHGTDTSEYLRRDRNEPMDLGTALFRYGLVKEPESDQMNFVITMHHAVYDGWSMPLVFDHVNSAFNGLHTERPTSFKHFIKHLTSLDPADAQQYWKKRLEGTSPHQFPPLPQKGYTTQADSLLEHYVTVPTSAHSKLTLATIIRGAWALVSSLYIGHPDIVFGETLTGRSAPVPGIEQIEGPMITTVPIRVRLSLDRPITEYLQMIHAVTVKQIPHEHLGLQNIRRLSKDARVACDLRTGLVLHPKEDEDWGKVSLETPANTFLPASDEEGAREALKFNTYALMLVCTLEENGFLVMASFDSNCISKEAMERVLVVLDRIVHAFLGNPESKLGDVAVLDPAEARDAEAMRPRDVMSDSALGMSPVDGLESMDASLKELSPNEEKLRNILGRILGMKETDIRPSDSFFDLGGDSIGAMRLVSDARAQGLNLTVAQVFQSRSLSDLAASASNEREDKLAEILSRILGIAKSDIKSSDSFFELGGDSIGAMRLVSDARAQGLSITVAQVFQSKSLAELASSAEEEMPSQPKTNVDAPFIALGKDANLHSPDRVGVYLENQEWEITNIYPTRPLQQLAVEGTVDLPRYSLRYELIKFATPIDRQKLEQACQELVARNEVLRTVFVKDNELTLGVVLSALRVPYTETAVPEGEDADAFIQAGIKQDIEAPKPYGSSFVAFNLFTHPNGASTLVFRISHAQYDEICLPILFEQLSALYSGTTVPETVPFSKHVNHVVLDNIPKAIPYWENLLSGSEMTVLKPTIPLTHRGPADIYREFDISSRPANITIGSLPTAAWALVLSRRLNLTDVVFGEVVSGRNVGAPNADRIFGPTWQYIPFRVPFSKSWSYLDLLRYVQDQHMTSAAYESMGFSEIVKNCTNWDEDKVQWFDTVVHQAPAWVEELPFGNGVEAKFQTLYPHGEPLREWKCQAFVKEGGRKLGIEIVTFEEWIGEAEGVLEEVGKALECLMEGRVGESIF
What is the function of this protein?
NRPS involved in extracellular coprogen-type siderophores biosynthesis including coprogen, neocoprogen I and neocoprogen II (PubMed:17056706).  The role of extracellular siderophores in fungal virulence to plants is to supply iron to the fungus during plant infection, but not to act as phytotoxins, depriving their hosts of iron (PubMed:17056706).
What are the official names of this protein?
Nonribosomal peptide synthetase 6, NPRS 6, Extracellular siderophore synthetase.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
Protein: TAF4_CANAL
Sequence: MTSTPQESSNLKRQLENSEDSSSPNKKSKTETTTENQSSWESDFNSLPVELLQTETNGTSPAPAPATPIDTTNVSNSKERDQDTSKLNDAIAAAGVDIQQEEEILLQQQLNRKSAEGMASNLKSVIRSSKSPPFLHNYHLAAFIDKVAKQNGIQQNFLMDGEMLELISAACETWLSNLATKTIILSRHRRRGIPVINKKSGSSSVPRSEISKELRSLALKQKEMEEKRVNKRVMLGLEKSTKDASKNDENGESKAGAEETLHRAANATAAMMTMNPGRKKYSWMTSSATAGGGSDFGKSSGGSSKDSGKHQSPIISVRGDNGLRFREIRSGNSIIMKDLLGAIEDEKMGTRNAVIKGYAKLKD
What is the function of this protein?
Functions as a component of the DNA-binding general transcription factor complex TFIID.  Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation.  TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (By similarity).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 4, TBP-associated factor 4.
What is the protein family that this protein belongs to?
Belongs to the TAF4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CRMB_CAMPS
Sequence: MKSVLYSYILFLSCIIINGRDVTPYAPSNGKCKDNEYKRHNLCCLSCPPGTYASRLCDSKTNTQCTPCGSGTFTSRNNHLPACLSCNGRCDSNQVETRSCNTTHNRICECSPGYYCILKGSSGCKACVSQTKCGIGYGVSGHTSAGDVICSPCGLGTYSRTVSSADKCEPVPSNTFNYIDVEINLYPVNDTSCTRTTTTGISESISTSELTITMNHKDCDPVFREEYFSVLNKVATSGFFTGENRYQNISKVCTLNFEIKCNNKGSSSKQLTKAKNDDGIMPHSETVTLVGDCLSSVDIYILYSNTNTQDYETDTISYHAGNVLDVDSHMPGSCDIHKLITNSKPTHFL
What is the function of this protein?
Inhibits host immune defense by binding to host TNF and various chemokines in the extracellular space.  Binds host CC chemokines (beta chemokines) and CXC chemokines (alpha chemokines).
What are the official names of this protein?
Soluble TNF receptor II, Cytokine response-modifying protein B.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG002 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CCA_ERWT9
Sequence: MKTYLVGGAVRDGLLNLPVKDKDWVVVGASPQQMLDRGYQQVGRDFPVFLHPESHEEYALARTERKSGRGYTGFTCYSAPDVTLEQDLARRDLTINAIAQDAGGNYCDPYGGRADLQQRLLRHVSGAFNEDPLRVLRVARFAARFAHLNFRIADETLLLMQAMTHSGELHHLTPERVWKETELALQTPSPQVFFQVLRDCGALAVLFPELDNLYGVPAPAKWHPEIDTGVHALMALAMAARLSQEIDIRFATLFHDVGKALTPKVKWPSHHGHGPAGVPLVAALCERLRVPNALRDLALLVTEFHDLVHTIQCQPPTELVALFDRVDAWRKPQRVQQIALTSEADARGRTGFENNPYPQGDYLREAWRVVQSVSTKEVVDAGFKGMAVREELTRRRIAALDAWKQVQ
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: RSMH_CHLPM
Sequence: MGGMKSCYHEPVLAPESVSMLVRGPGLYLDGTLGGGGHSLAILCELERSGWLEGSLLLGIDQDDEALQEAGERLADYREHAVALKGNFGNIAALSAREAGSRGMEPQASGILLDLGVSSHQLDVPLRGFSYMQPGPLDMRMDSGATGTAADILNTAPEAELASIFFRYGEEPLSRVIARAVTTRRVEKGPFHTTDELADLVRSVVFGRERVMKSLSRVFQALRIAVNQELEVLERVLGDGVMLLKPGGRMAVISYHSLEDRMVKRFFSSLTTADWGPKGVGLREPVRPAAAIAVTGKPVRAGAEEVARNPRARSAKMRVIEKMENRE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_SHEDO
Sequence: MLNKAMNIADYDPQLFKAIEDETRRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVVETLAIERAKELFGATYANVQPHSGSQANSAVYMALLKPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIIPYGIDEAGKIDYVEMERLAVEHKPKMMIGGFSAFSGIVDWAKMREIADKIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTSTTHKTLAGPRGGLILSAADDEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKTYQQQVVKNAKAMVEVFIERGYKIVSGGTDNHLMLVDLIGRDLTGKEADAALGSANITVNKNSVPNDPRSPFVTSGVRIGTPAITRRGFKEAEAKALTTWVCDILDDANNPAVIERVKGEVLALCAKYPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AADH1_SOLLC
Sequence: MANRNVPIPRRQLYIGGEWREPVKKNRIPIINPATEEIIGDIPAATAEDVDIAVEAARKAIARDDWGSTTGAQRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYESAADMDDVAGCFEYYAGLAEALDSRRMTPVNLNSDSYKSYVLREPLGVVGLITPWNYPLLMAIWKVAPALAAGCAAILKPSELASITCLELGEICREIGLPSGALNILTGLGPEAGGPLASHPHVDKISFTGSGPTGSKIMTAAAQLVKPVSLELGGKSPIVVFDDIDNLDIAAEWTLFGIFANTGQVCSATSRLIVQENIASAFMDRLLKWTKNIKISDPLEEDCKLGPVVSAGQYEKVLKFISNAKSEGATILCGGERPQHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFKTEEQAIELANDTKYGLGAAVMSKDVKRCERFTKAFQTGIIWINCSQPTFNELPWGGKKRSGFGRDLGKWGLENFLNIKQVTEYTSAEPLAFYKSPSKN
What is the function of this protein?
Dehydrogenase that catalyzes the oxidation of several aminoaldehydes (PubMed:23408433).  Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable).  Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively (PubMed:23408433).  Catalyzes the oxidation of 4-(trimethylamino)butanal and 4-guanidinobutanal to 4-trimethylammoniobutanoate and 4-guanidinobutanoate, respectively (PubMed:23408433).  Catalyzes with low efficiency the oxidation of betaine aldehyde to glycine betaine (PubMed:23408433).
What are the official names of this protein?
Aminoaldehyde dehydrogenase 1, SlAMADH1, 4-trimethylammoniobutyraldehyde dehydrogenase AMADH1, Aminobutyraldehyde dehydrogenase AMADH1, Betaine aldehyde dehydrogenase AMADH1, Gamma-guanidinobutyraldehyde dehydrogenase AMADH1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: EBNA2_EBVG
Sequence: MPTFYLALHGGQTYHLIVDTDSVGNPSLSVIPSNPYQEQLSDTPLIPLTIFVGENTGVPPPPPPPPQRRDAWTQEPSPLDWDPLGYDVGHGPLASAMRMLWMANYIVRQSRGDRGLILPQGPQTAPQAMLVQPHVPPLRPTAPTILSPLSQPRLTPPQPLMMPPRPTPPTPLPPATLTVPPRPTRPTTLPPTPLLTVLQRPTELQPTPSPPRMHLPVLHVPDQSMHPLTHQSTPNDPDSPEPRSPTVFYNIPPMPLPPSQLPPPAAPAQPPPGVINDQQLHHLPSGPPWWPPICDPPQPSKTQGQSRGQSRGRGRGRGRGRGKSRDKQRKPGGPWRPEPNTSSPSMPELSPVLGLHQGQGAGDSPTPGPSNAAPVCRNSHTATPNVSPIHEPESHNSPEAPILFPDDWYPPSIDPADLDESWDYIFETTESPSSDEDYVEGPSKRPRPSIQ
What is the function of this protein?
Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation.  Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC.  Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1.  Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription.  Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase.  It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells (By similarity).
What are the official names of this protein?
Epstein-Barr nuclear antigen 2, EBNA-2, EBV nuclear antigen 2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae EBNA2 family.
What are the subcellular locations of this protein?
Host nucleus matrix. Note=Associated with the nuclear matrix.
Protein: PROA_POLSJ
Sequence: MNAPDSPNALAARSELTDLMQRMGSGAKVASAHMARASAAVKNWALSKLATLLRQNVKALDNANQRDLARAQAAGLAGPLLDRLRLSPKDIETVALGCEQLAAMPDVIGEIIGMKEQPSGIRVGQMRVPIGVFGMIYESRPNVTIEAASLAIKSGNACILRGGSEAIESNKALASLVQQALLDAGLPADAVQLVPTTDREAVGLLIAMPQYVDVIIPRGGKGLIERISREAKVPVIKHLDGNCHVYVDDPCDIDMAVRVADNAKTQKYSPCNASEGLLVARGVAAGFLPKIGAVYAAKGVEMRCDAEARALLAGVAGANLQPVSEQDWYEEYLAPIISIKVVAGIDEAIAHINQYSSHHTDAILTRDHMHAQRFLREVDSASVMVNASTRFADGFEFGLGAEIGISTDKFHARGPVGIEGLTSLKYVVLGNGEVRT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.