PharMolix/UniProtQA huggingface dataset:
Protein: RAD54_ORYSJ
Sequence: MPSTSKCNRISRVADEEEEEEIVAVSSDADESESESEVGSGAEEEDDDYVGESSDSAGGSGSGSGDGDGDEEGGRSDIGDGEGEGGGRRVRSACRGVRANDRERKSQNVDALVRGNLVVRRQPLIPRILSVSDAAAIARKPFKPPCQNGYSENNEQLARRLSARKRFVPWGSVQPFAVTNILPQSPAVSSDDSVENEESLPPGIEPLILWQPEGRDKENSNFSAIKVDHLLVRYLRPHQREGVQFMFDCVSGLLNDDGISGCILADDMGLGKTLQSITLLYTLLCQGFDAKPMVKRAVVVTPTSLVSNWESEIIKWLKGRVQLLALCESTRADVLSGIESFLKPLSRLQVLIVSYETFRMHSSKFERPGSCDLLICDEAHRLKNDQTLTNKALAALPCKRRILLSGTPMQNDLEEFFSMVNFTNPGVLGDATYFRRYYEAPIICGREPTASAEEKNLGSERSAELSAKVNLFILRRTNALLSNHLPPKIVEVVCCKLTALQTALYNHFIHSKNVKRLISEGTKQSKVLAYITALKKLCNHPKLIYDTIKSNNSGGSGFDDCLRFFPPELFSGRSGSWTGGGGMWVELSGKMHVLARLLGHLRLKTDDRIVLVSNYTQTLDLFAQLCRERRYPYIRLDGATSINKRQKLVNQFNDPSRDEFVFLLSSKAGGCGLNLVGGNRLILFDPDWNPANDKQAAARVWRDGQKKRVYIYRFLSTGTIEEKVYQRQMSKEGLQKVIQQEQADGKMQGSSLSTEDLRDLFTFHEQIRSEIHENLKCNRCNKDGCMVLDGSKFDSAATEHEASNSGENSYIDIGGFGAISGCVQKMNSSNQQIGSPSEEDLGSWGHHSDPSTVPDTILQCSSGDEVSFVFTNQIDGKLVPVESMARAATHRTHEVTVNAEKEVGKINSSNVPGTERQSLLGKNLKMMGFNLKNSSMKFPTKSRRMLPNCLQGMNKTSTSSDHQQTKKLHVISDASDDDFV
What is the function of this protein?
Involved in DNA repair and mitotic recombination.
What are the official names of this protein?
DNA repair and recombination protein RAD54, OsRad54.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL36_AROAE
Sequence: MRVQASVKRLCRNCKIVRRKGVVRVICIDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: CYSH_BURCE
Sequence: MSTATATALTPELAAKVERLDALLAQIGERHDKVKFASSLAAEDMLLTHAILSKGVPIGIFSLNTGRLHAETLGMIDRVRERYGYEIEQFHPQQDAVDRYVAEHGLNAFYESVELRKSCCHIRKVEPLNRALADVGAWVTGQRREQSVTRAELHEEEQDEARGIAKYNPLADWTEADVWAYLKAFDVPVNPLHARGYPSIGCEPCTRAIRPGEDSRAGRWWWESRDTKECGLHITTITPIPANAEAGAAH
What is the function of this protein?
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
What are the official names of this protein?
Adenosine 5'-phosphosulfate reductase, APS reductase, 5'-adenylylsulfate reductase, Thioredoxin-dependent 5'-adenylylsulfate reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y461_HAEIN
Sequence: MSTKNHFIFPTYVQMYPYSKDRPFLKQVREKLRYYGYKWLYQKQCSQLVDFLNTETQWQSLFTQDYYRTNTILTTFCDKRFSASERLTAITENLRLAEEKMGRSLCQQLLDQQHIVLTQLTEDLRLSLSINHIDPFEGYFSINIRNQNNERVYDSSFTFLSPNKLLIASIQGPSSDNAQELVKQATKALHGMRPMFMLVNGFKMLAEKWQCELVGIPHKAQGKYRLSARSKILFNYDEFWQENQGEYRHNYWQLPLHIERKQLEDIASKKRSMYRKRYEMLDQMALDIQQL
What are the official names of this protein?
Uncharacterized protein HI_0461.
Protein: PETL_ACOCL
Sequence: MPTITSYFGFLLAASTITTALFIGLSKIRLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FENR_MYCGA
Sequence: MNIYDLIVLGAGTSGIYCASYGAMKGLSSLVIEMTDRIGGQPAHVYPFKKIYDFPTANGILAKDFVDQLYQQQKPYITQGLITYLHNTTIQEQNYLDDQQLFELKLSDNQHVKAKKIILATGNGGFEPIKLKDELIQDQNLDCIHYKINDLTQYQNKDLCFLGGGDSAVELINQLADLKIAKSLSIIHRNHKYRAAQALVDLINKKPINQYLDQTIELIKDNKISFKDNQSGESTQLNFDYLIVQYGLKPLKSLECFDHLEQDLNNNFVINHHHQTSDPNIYAIGLASNFSKRPNLILSGMYEATVAIKHINDTINPYLRATDYLLKE
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: SYDP_ECO55
Sequence: MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: APT_METM7
Sequence: MDLRKKIRIVEDFPIKGISFKDVTPILKDPKAMKHTTKEITKYLEDKNIDIIVGPEARGFLFGVPVAHELDIGFVPVRKPGKLPFKTFSVDYALEYGTDKLEIHSDGIEKGQNVAIVDDLLATGGTVSGVSKLVEKIGGHVSALNFVIELTELKGRDKLKGYDIQSLVKYDL
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMS_BACC1
Sequence: MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDENVATSVGIGHTRWATHGVPSKVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVSETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGLLDAENPNMIYVAKNKSPLLVGVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDASDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELDQDIRNAILDSDRIYIIACGTSYHAGLVGKQFIEKFAKMPVEVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQTNEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTKAYTAQLAVLSILAADIAKAKGEVLGFDLTHELGLVANAMVQLCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGALKLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPCIISMKGLEMEGDSFVLPAVHEALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBT7_ARATH
Sequence: MSSSSDTHAGESRHRRNPIRWLLGFGFFVQGFRGFPWLGANFFLTEQLRVNPSVLQLLQNSANLPMVAKPIYGVVSDSVYFFGQHRIPYIAVGALLQAISWLAIAFLSRSNVSILALSIYLLLSNLGASLVEVANDAIVAESGKQKTSETQSGELPSFVWMVSSLGGILGNLLGGIAIKTFSAQSTFLVFGILALLQFLVTINIREKSLNLPENPSPAGGIRKHLSDLSHVLRKPEISYSIAWIAVSTAVVPVLTGTMFFYQTKFLKIDASLLGISKVFGQIAMLLWGFAYNRWLKAMRPRKLLTAIQVTIAFFVISDLLFVKGVYRDLGVSDSVYVLFFSGFLETLFYFKILPFTVLMARLCPPGCEGSLMAFVMSAIALAFIVSGYLGIVLASFVGVTEDDFSGFTRGLAIEACCVGIPLILTSWIYDEAETKEKSKKIE
What is the function of this protein?
Could mediate folate transport.
What are the official names of this protein?
Probable folate-biopterin transporter 7.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL19_MANSM
Sequence: MSNIIKQLEQEQLKQNIPSFRPGDTLEVKVWVVEGAKKRLQAFEGVVIAIRNRGLHSAFTLRKVSNGTGVERVFQTHSPAIDSISVKRKGAVRKAKLYYLRERSGKSARIKERLGA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RPO2N_METTH
Sequence: MFWRKSMKKSAWGLVDAFFDKYDLVDHHIHSYNDFVSNRIQEIIDTSEPIELEQGKYRVETGKVSIEKPFIKEADGSKSKIYPTEARLRNLTYSAHMSLEMRLLKEGGPETEFEKVYIGELPVMLKSEICHLHGLSRKELMEKGEDPADPGGYFIVNGSERSIVTMEEIAPNKIILERIGEEDENRARAIVTSIRSGFRARISLEYRKPRKTGVFLRISFPYVPGEIPLVILLRALGLATDQEIITSISDDFNYQMIAADDIQVSLDRLNLNKKEMKELDEEDRREYLIRSAIKYIGNRVAKGMTEDYRIKRAEDVIDRYLLPHIGTEPEKRLEKATYLAEMTEMLLQVISGERRPHDKDHYTNKRLRVSGDLMEDLLRVAFTSLSRDMSYQLERSLARGKEPSVKQAVRSDVLTENLKHAIATGNWVGGRAGVSQLLDRTSYMGTLSHMRRVVSPLSRSQPHFEARDLHPTQFGKICPNETPEGPNCGLVKNLALLAKISEGSDASEVEEVIKMGVVN
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo2N, DNA-directed RNA polymerase subunit B''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MT2B_COLES
Sequence: MSCCGGNCGCGSGCQCGNGCGGCKMFPDFGSDEKITTTHTLVLGFAPAKGSVEGFEMVAGAAENDCKCGSNCSCTDCRCDPCNC
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.  Probably involved in maintaining homeostasis of essential transition metals and detoxification of toxic metals.  Increases cadmium and zinc tolerance when expressed in heterologous systems.  Metal chelator binding 6 cadmium or 5 zinc atoms per protein.
What are the official names of this protein?
Metallothionein type 2b, CeMT2b.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ICS2_ARATH
Sequence: MASLQCSFHFLGTNPKKYNPSSIFQSYSRTSFTKLSSRVSRQRFLRCTLSMNGCEADHKAPLGTVETRTLSTVPSPAAATERLITAVSDLKSQPPPFSSGIVRLQVPIEQKIGAIDWLHAQNEILPRSFFSRRSDSGRPDLLQDFSSDNGSSDHNPVSVAGIGSAVFFRDLDPFSHDDWRSIRRFLSSKSPLIRAYGGLRFDPTGKIAVEWEHFGSFYFTVPQVEFDEFGGSSMLAATVAWDNELSWTLENAIEALQETMLQVSSVIMRLRRESLGVIVVSKNHVPSEGAYYPAVNNALEIIKDKHSPLSKVVLARSSRIITDTDIDPIAWLARLQCEGQDAYQFCLQPPGAPAFIGNTPERLFHRKHLGVCSEALAATRPRGDSKVREMEIERDLLTSPKDDLEFSIVRENIREKLKTICDRVVVKPHKSVRKLARVQHLYSQLAGQLKREDDEFNILTALHPTPAVCGCPVEEARLLIKQIESFDRGMYAGPIGFFGGGESEFSVGIRSALVEKGLGALIYAGTGIVSGSNPSSEWNELELKISQFTKSLEHESALQPIN
What is the function of this protein?
Isochorismate synthase involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death.  Also involved in phylloquinone (vitamin K1) synthesis.  Has no isochorismate pyruvate lyase (IPL) activity.
What are the official names of this protein?
Isochorismate synthase 2, chloroplastic, AtIcs2, Isochorismate mutase 2, menF-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the isochorismate synthase family.
Protein: KV2A2_MOUSE
Sequence: MRCSLQFLGVLMFWISGVSGDIVITQDELSNPVTSGESVSISCRSSKSLLYKDGKTYLNWFLQRPGQSPQLLIYLMSTRASGVSDRFSGSGSGTDFTLEISRVKAEDVGVYYCQQLVEYP
What are the official names of this protein?
Immunoglobulin kappa variable 2-112, Ig kappa chain V-II region VKappa167.
Protein: NQOR_ACICJ
Sequence: MAKVLVLYYSTWGHVETMAKAVAEGAKAAGAEVTLKRVPETMPEDTAKAIHAKTDQDAPVATPAELADYDAIIFGTPTRFGNMCGQMRNFLDQTGGLWAKGALIGKVGSVFASTGTQHGGQETTITSFHTTLFHHGMIVVGVPYSNPELTNMNEITGGTPYGATTLAGADGSRQPSANELAIARAQGKHVAGIAAKLAG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: MDTK_YERPG
Sequence: MQKYIVEARSLLALAIPVVIAQLSQTAMGVVDTIMAGSVSATDMAAVAVGTSIWLPAILFGHGLLLALTPTVAQLNGSGRRSQIAHQVRQGFWLALCVSVLIMLVLYNSDHVIKQMDNIDPVLAQKAVGFLHAIMWGVPGYLFFQVLRNQCEGLSKTKPGMVIGFVGLLVNIPINYIFIYGKFGAPALGGVGCGVATASVYWVMFLMMRWYVTRARSQQDIKLEKGFAAPDWQVMKRLSGLGLPVALALFFEVTLFAVVALLVSPLGIVAVAGHQIALNFSSLMFMLPMSLSVAATIRVGFRLGQGAVEQAQVAAYTSMAVGLLLASVTAVFTIVFREHIALLYNKTPEVVTMASHLMLLAALYQLSDAVQVIGSGVLRGYKDTRSIFFITFTAYWLLGLPSGYLLGLTDYILPAMGPAGFWIGFIIGLTAAAILMVLRIRWLQKQPTAFILQRAAH
What is the function of this protein?
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
What are the official names of this protein?
Multidrug resistance protein MdtK, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KR124_HUMAN
Sequence: MCHTSHSSGCPMACPGSPCCVPSTCYPPEGYGTSCCCSAPCVALLCRPLCGVSTCCQPACCVPSPCQVACCVPVSCKPVLCVASFCPTSGCCQPFCPTLVYRPVTWSTPTGC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 12-4, High sulfur keratin-associated protein 12.4, Keratin-associated protein 12.4.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 12 family.
Protein: CH10_TERTT
Sequence: MNIRPLHDRVVVRRKEEEEKSAGGIVLPGSAKEKPNQGEVVAVGSGRVLDNGETRPVDVKVGDTVVFGKYAGSDTIEINGEELVILSESDIKAIIE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANP3_PSEAM
Sequence: DTASDAAAAAALTAABAAAAAKLTABBAAAAAAATAA
What is the function of this protein?
Contributes to protect fish blood from freezing at subzero sea water temperatures.  Lowers the blood freezing point.  Binds to nascent ice crystals and prevents further growth.
What are the official names of this protein?
Ice-structuring protein 3, ISP 3, Antifreeze peptide 3.
What is the protein family that this protein belongs to?
Belongs to the type-I AFP family.
Protein: RR4_IRIDM
Sequence: RFKKIRRLGALPGLTSKRPRSGSDLKNQLRSGKRSQYRIRLEEKQKLRFHYGLTERQLLKYVHIAGKAKGSTGRVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGHIVDIPSYRCKPRDIITTKDKQRSKALIQNYIALSPHEELPNHLTIDPFQYKGLVNQIIDSKWIGLKIN
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: 1433F_TOBAC
Sequence: MSSSRDEFVYMAKLAEQAERYEEMVDFMEKVVTAADGGEELTIEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEDHVTSIKTYRSKIESELTSICNGILKLLDSNLIRAASTGDSKVFYLKMKGDYHRYLAEFKTGAERKEAAENTLSSYKSAQDIANAELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQDEGTEEMKEVAKPDNEEH
What are the official names of this protein?
14-3-3-like protein F.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: GL_GAHVM
Sequence: MKIYRVLVHLSFVLGMFTKTNTVLAWSKYDLVHGFMRVANISSIMRLDCLPNLLSSNAGYAALPSDDIPTGIFIKVNCSIPEFILWYEQKAMAAWINPIMGTVLMMNDVLKSGLENSVKVGLLTFLKRIAEKGPNGPLRNRGSGCINLIAPADISCYGSTRLDRFNRDFEDDSRGMPCRAKAMRRTTSGSRRANA
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Acts as a functional inhibitor of gH and maintains gH in an inhibited form.  Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.
What are the official names of this protein?
Envelope glycoprotein L, gL.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein L family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans- Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans- Golgi where secondary envelopment occurs.
Protein: MURD_SHEON
Sequence: MQSQYSHIVLGLGATGLSVVRYLCGKGITPLVMDSRRQPPGAETLASSFPEVKLIAGGFDCRYLVQATQIIISPGIAMNTPEVRAALDMGIEVIGDVELFAREIADRKPCVIGITGSNGKTTVTTLVGEMLREAGIAVAVGGNIGIPALDLLKENADIFVLELSSFQLETTHSLNCVASTCLNVTEDHMDRYSDMDAYRKAKLRLYHQSRSIIFNRDDALTIPTEPMNQNSFGLAPPEGDEWGICDSKIYHGHSEIMPITEVSLIGSHNHANLLAAMALVYAVGVDKQVMANVARTFTGLSHRCEVVGVKGGVTYVNDSKATNVGATVAALDGLSDHLGDIILIAGGDGKGADFSPLEEPLTKVTHLITLGRDGNKIAALKEGAIKVDSMAAAVAKAAQLATSGDIVLLSPACASLDMYSNFMARGDDFRSQVEQLDGE
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIM12_RAT
Sequence: MWPVLWTVVRTYAPYVTFPVAFVVGAVGYHLEWFIRGKDPQPVEEEKSILERREDRKLDEMLGKDHTQVVSLKDKLEFAPKAVLNRNRPEKN
What are the official names of this protein?
Small integral membrane protein 12.
What is the protein family that this protein belongs to?
Belongs to the SMIM12 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NSMF_HUMAN
Sequence: MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGCYEGSLSEEPSIRKPAGEGPQPRVYTISGEPALLPSPEAEAIELAVVKGRRQRHPHHHSQPLRASPGGSREDVSRPCQSWAGSRQGSKECPGCAQLAPGPTPRAFGLDQPPLPETSGRRKKLERMYSVDRVSDDIPIRTWFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEAFEDLDWDTEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIERKLNVYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYRVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL
What is the function of this protein?
Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes.  Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway.  Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
What are the official names of this protein?
NMDA receptor synaptonuclear signaling and neuronal migration factor, Nasal embryonic luteinizing hormone-releasing hormone factor, Nasal embryonic LHRH factor.
What is the protein family that this protein belongs to?
Belongs to the NSMF family.
What are the subcellular locations of this protein?
Nucleus. Nucleus envelope. Nucleus membrane. Nucleus matrix. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Synapse. Synapse, synaptosome. Postsynaptic density. Membrane. Note=Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium. Associates with transcriptionally active chromatin regions. Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in a importin-dependent manner (By similarity).
Protein: S27A2_RAT
Sequence: MLPVLYTGLAGLLLLPLLLTCCCPYLLQDVRFFLQLANMARQVRSYRQRRPVRTILHVFLEQARKTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALFMGNEPAYVWLWLGLLKLGCPMACLNYNIRAKSLLHCFQCCGAKVLLASPELHEAVEEVLPTLKKEGVSVFYVSRTSNTNGVDTVLDKVDGVSADPIPESWRSEVTFTTPAVYIYTSGTTGLPKAATINHHRLWYGTSLALRSGIKAHDVIYTTMPLYHSAALMIGLHGCIVVGATFALRSKFSASQFWDDCRKYNATVIQYIGELLRYLCNTPQKPNDRDHKVKIALGNGLRGDVWREFIKRFGDIHIYEFYASTEGNIGFMNYPRKIGAVGRENYLQKKVVRHELIKYDVEKDEPVRDANGYCIKVPKGEVGLLICKITELTPFFGYAGGKTQTEKKKLRDVFKKGDVYFNSGDLLMIDRENFIYFHDRVGDTFRWKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGRIGMASIKMKENYEFNGKKLFQHISEYLPSYSRPRFLRIQDTIEITGTFKHRKVTLMEEGFNPSVIKDTLYFMDDTEKTYVPMTEDIYNAIIDKTLKL
What is the function of this protein?
Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (By similarity).  Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:8939997, PubMed:10640429).  Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:8939997, PubMed:10640429).  Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (By similarity).  May contribute to the synthesis of sphingosine-1-phosphate (By similarity).  Does not activate C24 bile acids, cholate and chenodeoxycholate.  In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.  However, it is not critical for THCA activation and bile synthesis in vivo (By similarity).
What are the official names of this protein?
Long-chain fatty acid transport protein 2, Arachidonate--CoA ligase, Fatty acid transport protein 2, FATP-2, Fatty-acid-coenzyme A ligase, very long-chain 1, Long-chain-fatty-acid--CoA ligase, Phytanate--CoA ligase, Solute carrier family 27 member 2, THCA-CoA ligase, Very long-chain acyl-CoA synthetase, VLACS, VLCS, Very long-chain-fatty-acid-CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Peripheral membrane protein. Cell membrane; Multi-pass membrane protein. Microsome.