PharMolix/UniProtQA huggingface dataset:
Protein: S38A2_PANPA
Sequence: MKKAEMGRFNISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH
What is the function of this protein?
Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane.  The trasnport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1.  May function in the transport of amino acids at the blood-brain barrier (By similarity).  May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity).  Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity).  Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity).
What are the official names of this protein?
Sodium-coupled neutral amino acid symporter 2, Amino acid transporter A2, Solute carrier family 38 member 2, System A amino acid transporter 2, System A transporter 1, System N amino acid transporter 2.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.
Protein: PA2_SCOVI
Sequence: MSSKIPLLFIISFGLYVSTTNSSPIERRSLWNFFFMTFIGGKRAPWKYDGYGNHCGIGGKGSPVDSIDRCCQVHDRCYHEVNENECGSYKRNVKFIDYDWYMQDKQIVCDTTDTVCAQAICKCDKDIVECLNQNDKDYNPKYNKAIG
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 Scol/Pla, PLA2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TMM95_HUMAN
Sequence: MWRLALGGVFLAAAQACVFCRLPAHDLSGRLARLCSQMEARQKECGASPDFSAFALDEVSMNKVTEKTHRVLRVMEIKEAVSSLPSYWSWLRKTKLPEYTREALCPPACRGSTTLYNCSTCKGTEVSCWPRKRCFPGSQDLWEAKILLLSIFGAFLLLGVLSLLVESHHLQAKSGL
What is the function of this protein?
Sperm protein required for fusion of sperm with the egg membrane during fertilization.
What are the official names of this protein?
Sperm-egg fusion protein TMEM95, Transmembrane protein 95.
What is the protein family that this protein belongs to?
Belongs to the TMEM95 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Note=Following the acrosome reaction, relocalizes to the equatorial segment.
Protein: CLPX_NITMU
Sequence: MSEKTGGEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIELCNDIIREEIQGVEAAKLAKSDLPVPHEIRQILDQYVIGQEQAKKILSVAVYNHYKRLRTLAKSADPDEIELAKSNILLIGPTGSGKTLLAQTLARLLDVPFVMADATTLTEAGYVGEDVENIIQKLLQKCNYDAEKAQQGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFVQVDTTNILFICGGAFDGLEKIIRARSEKGGIGFSASVRSQDNRKDFGAVLRGVEPEDLVKYGLIPEFVGRLPVVATLEELDEAALIQILTEPRNALIKQYQKMFHMEGGIDLEFREQALKAIARKALVRKTGARGLRSILEAALLDTMFDLPSLENVAKVVIDHTSVNGDIKPILIYSDKPKVAKSC
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RL28_BOVIN
Sequence: MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVMKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKPSRPTKSS
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL28 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_SHESR
Sequence: MSLADSVLAVNNDLPIRTDSPVHSGKVRSVYWLTDADSRRLIQTKGYNVPEDTPLAIMVISDRISAFDCIFHGEGGLKGIPGKGAALNAISNHWFKLFAENGLADSHILDIPHPFVWIVQKARPIKVEAICRQYITGSMWRAYSKGERVFCGITLPEGLEKDQKLPDLLITPSTKGILTGIPGVPAQDDVNISRSDIEANYQAFGFEKVEDIDLYEKLLKDGFKVIAKALADLDQVFVDTKFEFGYVTDKNGNSKLIYMDEVGTPDSSRIWDGAAYRDGKILENSKEGFRQFLLNHFPDPDILLNKDRMPEREALARDNALPLEAMMDVSRTYTGIAEKVTGAAIPLPANPKADIIKILREEYDLIV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: OPGG_ECO81
Sequence: MMKMRWLSAAVMLTLYTSSSWAFSIDDVAKQAQSLAGKGYEAPKSNLPSVFRDMKYADYQQIQFNHDKAYWNNLKTPFKLEFYHQGMYFDTPVKINEVTATAVKRIKYSPDYFTFGDVQHDKDTVKDLGFAGFKVLYPINSKDKNDEIVSMLGASYFRVIGAGQVYGLSARGLAIDTALPSGEEFPRFKEFWIERPKPTDKRLTIYALLDSPRATGAYKFVVMPGRDTVVDVQSKIYLRDKVGKLGVAPLTSMFLFGPNQPSPANNYRPELHDSNGLSIHAGNGEWIWRPLNNPKHLAVSSFSMENPQGFGLLQRGRDFSRFEDLDDRYDLRPSAWVTPKGEWGKGSVELVEIPTNDETNDNIVAYWTPDQLPEPGKEMNFKYTITFSRDEDKLHAPDNAWVQQTRRSTGDVKQSNLIRQPDGTIAFVVDFTGAEMKKLPEDTPVTAQTSIGDNGEIVESTVRYNPVTKGWRLVMRVKVKDAKKTTEMRAALVNADQTLSETWSYQLPANE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: B5_HHV6Z
Sequence: MRCSHNVNIGQRQPRKRPLQQQQQHQLQQQTRAGSRSVNSRISVAQRVLAVPTDYGRSPARDCGHFPLYHVRRKLIDGR
What are the official names of this protein?
Protein B5.
Protein: PLY1_CHAOB
Sequence: MASCTLLAVLVFLCAIVSCFSDNPIDSCWRGDANWDQNRMKLADCAVGFGSSAMGGKGGAFYTVTSSDDDPVNPAPGTLRYGATRERSLWIIFSKNLNIKLNMPLYIAGNKTIDGRGAEVHIGNGGPCLFMRTVSHVILHGLNIHGCNTSVSGNVLISEASGVVPVHAQDGDAITMRNVTDVWIDHNSLSDSSDGLVDVTLASTGVTISNNHFFNHHKVMLLGHSDIYSDDKSMKVTVAFNQFGPNAGQRMPRARYGLIHVANNNYDPWSIYAIGGSSNPTILSEGNSFTAPNDSDKKEVTRRVGCESPSTCANWVWRSTQDSFNNGAYFVSSGKNEGTNIYNNNEAFKVENGSAAPQLTKNAGVLTCILSKPCS
What is the function of this protein?
Has pectate lyase activity.
What are the official names of this protein?
Pectate lyase 1, Major pollen allergen Cha o 1.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family. Amb a subfamily.
Protein: CATC_CANLF
Sequence: DTPANCTHPELLGTWVFQVGPAGSRSVNCSVMGPPEKKVVVHLEKLDTAYDNFGNTGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGHKVTSYCNETMTGWVHDVLGRNWACFTGTKMGTTSEKAKVNTKHIERLQENNSNRLYKYNYEFVKAINTIQKSWTATRYIEYETLTLRDMMTRVGGRKIPRPKPTPLTAEIHEEISRLPTSWDWRNVRGTNFVSPVRNQASCGSCYAFASTAMLEARIRILTNNTQTPILSPQEIVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYAGSDSPCKPNDCFRYYSSEYYYVGGFYGACNEALMKLELVRHGPMAVAFEVYDDFFHYQKGIYYHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGSRWGEDGYFRIRRGTDECAIESIAVAATPIPKL
What is the function of this protein?
Thiol protease.  Has dipeptidylpeptidase activity.  Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids.  Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate.  Can act as both an exopeptidase and endopeptidase.  Activates serine proteases such as elastase, cathepsin G and granzymes A and B.
What are the official names of this protein?
Dipeptidyl peptidase 1, Cathepsin C, Cathepsin J, Dipeptidyl peptidase I, DPP-I, DPPI, Dipeptidyl transferase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: RUVA_TREPA
Sequence: MFESISGILTLHERERLCVEVHGIEWEIAVSAYSSAAFGEVGSHVKVFTWLYHREDALRLFGFSNVQERTLFLSLTKVEGIGPKQALKVLSSISSQALCAALDTGDLCALQRIPGIGKKTAQRMLLALKGTLALTDAASCAQSQTDDRAAHPSNLGCAPHAREIEDLVTALVQMGYDRKMAAEVIAQESAALCSVGRSLYEEEATVLKRAILALSIAHPHAVAPAAE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RLME_XANOR
Sequence: MPSRSKSSQRWLKEHFADPYVKKARAEGMRSRAAYKLEELLQRDRLLKPGMVVVDLGAAPGGWSQQVRKSMGDSGRVVALDILDMPALAGVEFLHGDFREQAVLSQFEAMLGDVPVDLVLSDMAPNKSGMDAVDQPRMMHLAELAMEFADAHLKPGGAFLIKLFQGVGSDDYIRELRRRYEKVTIRKPAASRKRSPEVYALGQGKRVQIK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCRO_BP434
Sequence: MQTLSERLKKRRIALKMTQTELATKAGVKQQSIQLIEAGVTKRPRFLFEIAMALNCDPVWLQYGTKRGKAA
What is the function of this protein?
Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth.  It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.
What are the official names of this protein?
Regulatory protein cro, Antirepressor.
Protein: ASSY_YERPE
Sequence: MTTILKHLPINQRVGIAFSGGLDTSAALLWMQKKGAIPYAYTANLGQPDEEDYEAIPRKAMEYGAEKARLIDCRKQLVAEGIAAIQCGAFHNTTAGVTYFNTTPLGRAVTGTMLVAAMKEDDVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDTDFIDELGGRHEMSEFMIQSGFDYKMSTEKAYSTDSNMLGATHEAKDLEFLNSSVKIVNPIMGVKFWDENVVVKAEEVTVRFERGYPVALNGVVFDDSVELMMEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHANGRVLGRLLYQGRWFDPQALMLRDSIQRWVASEITGEVTLELRRGNDYSILNTVSDNLTYKPERLTMEKGDSVFSPDDRIGQLTMRNLDITDTREKLFNYVETGLLTSSAATGLPQVDNNNLSSGRGLQDKRQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPX_SALTI
Sequence: MSQTVHFQDNPVTVANVIPQAGSKAQAFTLVAKDLSDVSLSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLATEVENTVVLCVSADLPFAQSRFCGAEGLSNVITLSTLRNNEFLKNYGVEIVDGPLKGLAARAVIVLDENDNVIFSQLVDEITHEPDYDAALNVLKA
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: WFDC5_PANTR
Sequence: MRTQSLLLLGALLAVGSQLPAVFGRKKGEKSGGCPPDDGPCLLSVPDQCVEDSQCPLTRKCCYRACFRQCVPRVSVKLGSCPEDQLRCLSPMNHLCHKDSDCSGKKRCCHSACGRDCRDPARG
What is the function of this protein?
Putative acid-stable proteinase inhibitor.
What are the official names of this protein?
WAP four-disulfide core domain protein 5.
What are the subcellular locations of this protein?
Secreted.
Protein: PGK_PAEAT
Sequence: MTSHTLNELIAEGVRGRYILVRSDLNVPLDGSAVTDDGRIKASLPVLKKLSDAGARVLVTAHLGRPKGAPEDKYSLKPAAARLAELADFKVQLANDTVGDSAKELAAGLQDGEVLVLENVRFDARETSKDDAERGAFADELVALTGTNGAYVDDAFGAVHRKHASVFDVATRLPSYLGDLVHTEVEVLRKLTTDTQRPYVVVLGGSKVSDKLAVIDNLLGKADTILVGGGMLFTFLAAAGHKVAGSLLEEDQIPVVQDYLKRASDAGTSFVIPTDVVVASRFAADAEHEVVKADAIEDSTFGASGIGLDIGPESAAAFAAQIEGAKTVFWNGPMGVFEFEAFSSGTRAIAQALTDTVAFTVVGGGDSAAAVRTLGFEDSQFGHISTGGGASLEYLEGKELPGLSVLDR
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YYBP_BACSU
Sequence: MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKTFAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNETLQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE
What are the official names of this protein?
Uncharacterized lipoprotein YybP.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: CTNB1_XENLA
Sequence: MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEDEDVDTNQVLYEWEQGFSQSFTQDQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYSYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDSSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSIGGTQQQFVEGVRMEEIVEGCTGALHILARDIHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCDVAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMPWNEAADLGLDIGAQGEPLGYRQDDSSYRSFHAAGYGQDAMGMDSMMDHDMGGHHPGADYPVDGLPDLSHAQDLMDGLPPGDSNQLAWFDTDL
What is the function of this protein?
Key downstream component of the canonical Wnt signaling pathway.  In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome.  In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity).  Plays a key role in dorsoventral patterning: in prospective ventral blastomeres, its down-regulation by axin1 and axin2 leads to inhibit the Wnt signaling pathway, while in prospective dorsal blastomeres, degradation of axin results in stabilization and nuclear translocation of ctnnb1 (By similarity).
What are the official names of this protein?
Catenin beta-1, Beta-catenin.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation). Translocates to the nucleus when it is stabilized (low level of phosphorylation). The majority of beta-catenin is localized to the cell membrane (By similarity). Reduced nuclear localization seen in the presence of custos (PubMed:25157132).
Protein: PSTB_SYNAS
Sequence: MVTLDTQSIIRTVNVNFYYGRFQALTDITMDFQKNRVTALIGPSGCGKSTLLRLLNRMNDLIDGCRVEGQVLFEDQNIYAPEMDPVEVRRRIGMVFQKPNPFPKTIFDNIAYGPRLHGFRKRSDLEALVESSLQQAVLWEEVKDILPRSAMTLSGGQQQRLCIARALAMKPDVLLMDEPTSALDPISTAKIEELIDELKENYTIIIVTHNMQQAARVSGMTGFFYLGKLIEYNATEKIFTNPEQKQTEDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL20_BACC0
Sequence: MPRVKGGTVTRQRRKKVIKLAKGYYGSKNTLFKVANQQVMKSLMYAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKNAGIEVNRKMLADLAVHDEKAFAELATVAKNNIN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: KEFC_ECOL6
Sequence: MDSHTLIQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLWKLRAAVFGGGALQMVICGGLLGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAIPLVAMIPLLAASSASTTMGAFVLSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILLLGFLIIKIAMLWLIARPLQVPNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEEAREADEIDEEQPRVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQLTEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAMVENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefC, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GUF1_CULQU
Sequence: MLSFLRLSQLGRIGVQQRFKPLIHRTLSTSCRRFSVDIAYDEIPVSRIRNFSIIAHVDHGKSTLADRLLELTGTIKKNATNKQVLDSLQVEKERGITVKAQTASLLYRYEGSDYLLNLIDTPGHVDFANEVSRSLAACDGVILLVDANEGVQAQTVANYHLARGKELVIVPVLNKIDLKNARPDAVTQELFTLFGIDPDGVLRISAKQGTGCEQVLVEIVKRLPAPDVRRGEQFRALIFDSWFDRYRGALNLVYVKDGEVRVGQEIVSCHTGKVYEVKSLAMLRPDEQKIERLVAGQVGLLGCNMRTSKESNIGDTLYLKKNKNCEPLPGFKPQQPMVFAGVYPADQSQHPYLKGAIEKLVLNDSAVTVVPDSSPALGQGWRLGFLGLLHLDVFSQRLQQEYDAEPILTAPSVTYKIKLKGIKMIAAHGGKDTIFVSNPALFPDPNSVEEYYEPYVLGTIIAPTECTGPIIGLCVERRAVQKTSINIDNDRIMTTYLMPLNEIVLDFHDQLKSISSGYASFDYEDHGYVASALVRMDVLLNGTLVDELCTVVHISKAQSHARELVLKLKELIPRQMVQIAIQATVGGKVVARETLKAYRKDVTAKLYGGDVTRRMKLLKQQAEGKKKMRAIANINVPRDTFINVLKR
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1 homolog, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1 homolog, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RADA_LISMO
Sequence: MAKAKRTTKFVCQACGYESAKWMGKCPNCNEWNQMVEALEPSKKSRSAFNHTGEPSKATPITQIASETEKRVETNMPELNRVLGGGVVPGSMVLVGGDPGIGKSTLLLQVSAQLTLTNKKVLYISGEESIKQTKLRAERLQVSGDNLYVYAETNLEAVQETIDFVKPDFVVIDSIQTVYHSDVTSAAGSVSQVRECTATLMRIAKMQNIAIFIVGHVTKEGAIAGPRLLEHMVDTVLYFEGERHHAYRILRAVKNRFGSTNEMGIFEMRDVGLVEVANPSEVFLEERLEGASGSTVVASMEGTRPVLVEIQALVSPTMFGNAKRMATGIDYNKVSLIMAVLEKRVGLMLQNQDAYLKAAGGVKLDEPAVDLAVAVSVASSYRDKPTRSTDCFIGELGLTGEIRRVARIEQRVQEAAKLGFKRIFIPKNNEGNWKIPKDVQVVGVETIGEALKKALPD
What is the function of this protein?
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks.  Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster.  Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB.  Does not have RecA's homology-searching function.
What are the official names of this protein?
DNA repair protein RadA, Branch migration protein RadA.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RadA subfamily.
Protein: MNHC1_STAAE
Sequence: MEIIMIFVSGILTAISVYLVLSKSLIRIVMGTTLLTHAANLFLITMGGLKHGTVPIYEANVKSYVDPIPQALILTAIVIAFATTAFFLVLAFRTYKELGTDNVESMKGVPEDD
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit C1, Mnh complex subunit C1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PHOSP_RABVN
Sequence: MSKIFVNPSAIRAGLADLEMAEETVDLINRNIEDNQAHLQGEPIEVDSLPEDMSRLHLDDGKLPDLGRMSKAGEGRHQEDFQMDEGEDPSLLFQSYLDNVGVQIVRQMRSGERFLKIWSQTVEEIISYVTVNFPNPSGRSSEDKSTQTTSQEPKKETTSTPSQRKSQSLKSRTMAQTASGPPSLEWSATNEEDDLSVEAEIAHQIAESFSKKYKFPSRSSGIFLYNFEQLKMNLDDIVKEAKNVPGVTRLAHDGSKLPLRCVLGWVALANSKKFQLLVEANKLNKIMQDDLNRYASC
What is the function of this protein?
Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication.  Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA.  Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus.  Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).  Inhibits interferon induction pathways by interacting with host TBK1 and preventing the formation of dynamic cytoplasmic condensates that have liquid properties and that are essential for interferon production (By similarity).
What are the official names of this protein?
Phosphoprotein, Protein P, Protein M1.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus protein P family.
What are the subcellular locations of this protein?
[Phosphoprotein]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P2]: Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P3]: Host nucleus. SUBCELLULAR LOCATION: [Isoform P4]: Host nucleus. SUBCELLULAR LOCATION: [Isoform P5]: Host nucleus.
Protein: CRCB_IGNH4
Sequence: MKALVWVAVGGALGAIVRYFFYKFVPQVYDFPLATFLVNVVASFLLGFIIGAFEAKPWGQQLKLALATGFCGALSTFSTFAADNYILLRSSKYITAFVYTAVSVGLGIVSVALGEDLAQRLLK
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.