PharMolix/UniProtQA huggingface dataset:
Protein: DMXR6_CRYX8
Sequence: MAASPISLDPSHVGIIKVANIPSDSLTECNKLLMKNHEEYHMFFRDTAGHNHIVHSLLTILSLGASPKQLQDRYDDGIPIQRPIPKIDHELLEKLSDPEILLKTIGEITQYHTLLEFFKREIAAKGWKEAIQEYVLARTKIADTILARMYEGAYHPIIHLGLGIEFQQPIIVAEALAQAASHDNSNIGTLFHNAEAEAGISYPSRIPKPMIELINEVRANETIRTAPRWTDFGNKMRDGVVGRAGEAMASLAAQFRIRNDEEELKRSTAEMISTCAFFAGASQHEGRKKKIDFFYMHNVTSSLFFTVFIRQDWIKLEDRVRLVEWKARLDLAWYAVSGSAALDAKWISDYSNPASDGMGWEDLFTAVNEEHDDGHAAKFIRALKNGEQECSKYEQGEWADYFPMKGDMWLKLARMCQDTTTNRPPDLKWVPFTGFDQPWKRPDLAN
What is the function of this protein?
Baeyer-Villiger monooxygenase; part of the gene cluster that mediates the biosynthesis of the dimeric xanthones cryptosporioptides (PubMed:30996871).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase dmx-nrPKS (Probable).  The atrochrysone carboxyl ACP thioesterase dmxR1 then breaks the thioester bond and releases the atrochrysone carboxylic acid from dmx-nrPKS (Probable).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase dmxR15, and oxidized by the anthrone oxygenase dmxR16 to yield emodin (Probable).  Emodin is then reduced to emodin hydroquinone by the oxidoreductase dmxR7 (Probable).  A-ring reduction by the short chain dehydrogenase dmxR18, dehydration by the scytalone dehydratase-like protein dmxR17 and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:30996871).  Baeyer-Villiger oxidation by the Baeyer-Villiger monooxygenase (BVMO) dmxR6 then yields monodictylactone in equilibrium with monodictyphenone (PubMed:30996871).  In the case of the cryptosporioptides biosynthesis, monodictylactone is reduced at C-12 to an alcohol (by the short chain dehydrogenases dmxR12 or dmxR8) and hydroxylated at C-5 by dmxR9, yielding the electron-rich aromatic which could eliminate H(2)O to form the ortho-quinonemethide, followed by tautomerisation to paraquinone and complete the formal reduction to produce the 10-methylgroup (Probable).  Conjugate addition of C-4a-OH to the resulting paraquinone by the monooxygenase dmxR10 then gives cyclohexadienone, which is then reduced at C-5 by the short chain dehydrogenase dmxR3 to give the dihydroxanthone (Probable).  The 6,7-epoxide in the cryptosporioptides could be introduced by the cytochrome P450 monooxygenase dmxL3 (Probable).  The highly reducing PKS dmxL2 manufactures butyrate, which is further carboxylated by dmxL1 to form ethylmalonate (PubMed:30996871).  It is not yet clear whether the carboxylation occurs while the butyrate is attached to the ACP of dmxL2, but this unusual fungal metabolite could then be esterified to O-5 by the O-acetyltransferase dmxR13 (PubMed:30996871).  Finally, dimerization performed by dmxR5 gives the observed dimers cryptosporioptides A, B and C as the final products of the pathway (PubMed:30996871).
What are the official names of this protein?
Baeyer-Villiger monooxygenase dmxR6, BVMO dmxR6, Dimeric xanthone biosynthesis cluster protein R6.
What is the protein family that this protein belongs to?
Belongs to the AflY oxidoreductase family.
Protein: SSY1_WHEAT
Sequence: MAATGVGAGCLAPSVRLRADPATAARASACVVRARLRRVARGRYVAELSREGPAARPAQQQQLAPPLVPGFLAPPPPAPAQSPAPTQPPLPDAGVGELAPDLLLEGIAEDSIDSIIVAASEQDSEIMDAKDQPQAKVTRSIVFVTGEAAPYAKSGGLGDVCGSLPIALAARGHRVMVVMPRYLNGSSDKNYAKALYTAKHIKIPCFGGSHEVTFFHEYRDNVDWVFVDHPSYHRPGSLYGDNFGAFGDNQFRYTLLCYAACEAPLILELGGYIYGQNCMFVVNDWHASLVPVLLAAKYRPYGVYRDSRSTLVIHNLAHQGVEPASTYPDLGLPPEWYGALEWVFPEWARRHALDKGEAVNFLKGAVVTADRIVTVSQGYSWEVTTAEGGQGLNELLSSRKSVLNGIVNGIDINDWNPTTDKCLPHHYSVDDLSGKAKCKAELQKELGLPVREDVPLIGFIGRLDYQKGIDLIKMAIPELMREDVQFVMLGSGDPIFEGWMRSTESSYKDKFRGWVGFSVPVSHRITAGCDILLMPSRFEPCGLNQLYAMQYGTVPVVHGTGGLRDTVETFNPFGAKGEEGTGWAFSPLTVDKMLWALRTAMSTFREHKPSWEGLMKRGMTKDHTWDHAAEQYEQIFEWAFVDQPYVM
What are the official names of this protein?
Starch synthase 1, chloroplastic/amyloplastic, Starch synthase I-2, SS I, SS I-2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, amyloplast. Note=Amyloplast or chloroplast, soluble.
Protein: AVL9_SCHPO
Sequence: MDENGASFQVLCLATIGFHHLRGPEIEHLFPESMDFPKEWSILPFLSLPDGAHSSEKDFVYFTLPFPNDEGTVFGLSCTRQLNASSLKNIPSDVTRSSVQKAVVVITTSPPFGHIKDNLDIVTNAYFSQGDFSNLDVLRDFFHVLTRKEQDVHIALNINLKSFLCEWRQNALVLLKVLLLGKRILVYDKSAERLGNFQYSLLSLIPCMMSHLQDVSSPSAHSLEKSLHKPASLQTSDKRSLLAYTGFPLIIFGEGSMFSPYTPLQLVHVLEAKSSTSWLAGTTNTLIMLNQNKMAEVIVRSDTHQIEFVDPTIKNLTSLTYTDKSWMEDIISRVESSLEMELPGFEGSDDWIRNQFELYIFGMLATVKYYNFLKKQDDSILSQYHYLPSTSCISDYGETFLLEWMKTNTFRIWNNIADDDLFDVILPKHPCKEEHKVPISARIATLFSAVKITPKSRDGEDEGSKEPAV
What is the function of this protein?
Functions in the late secretory pathway.  Required for the generation of secretory vesicles as well as for actin polarization and polarized growth (By similarity).
What are the official names of this protein?
Late secretory pathway protein avl9.
What is the protein family that this protein belongs to?
Belongs to the AVL9 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y0199_DICDI
Sequence: MVVKIVEAYEKVDQVKILFKEYVEWLNIDLSFQNFSEEFNSLPGKYSIENDGRLYIAYSDESLAGCVGLRKINIEINENKNNQQVDHDETSTIIIKKEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKICEMKRLFVKSEFRGLKIGKLLVERLINDAKEQNYDYMVLDTLKTLTTAISIYKSFGFIEFDPYYYNPNSNDVTFLKLKLK
What are the official names of this protein?
Uncharacterized N-acetyltransferase DDB_G0290199.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: AMPA_MYCTA
Sequence: MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEIEAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPKDAGLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLSESVGLDVEVIDEKALKKAGYGGVIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLRLPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTRIPGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAGPAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPH3_YEAST
Sequence: MSTYDEIEIEDMTFEPENQMFTYPCPCGDRFQIYLDDMFEGEKVAVCPSCSLMIDVVFDKEDLAEYYEEAGIHPPEPIAAAA
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:18627462, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323, PubMed:25543256).  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323).  Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state (PubMed:34154323).  Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM (PubMed:34154323).  Together with ATS1; associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex (PubMed:25543256, PubMed:27694803, PubMed:18627462).  The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:25543256).
What are the official names of this protein?
Diphthamide biosynthesis protein 3, Kluyveromyces lactis toxin-insensitive protein 11.
What is the protein family that this protein belongs to?
Belongs to the DPH3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SERC_LEPBP
Sequence: MPTFTHRIYNFNAGPAMLPTEVMEEAKSEFLNFRGTGMSVMEMSHREKHFQSILDESISDLRELLNLPSRYAVVYFPGGATLQFSAIPFNYLSSGDSCDFALTGVWAKKAFEEAKKFYPNVKSIFNGADSKYMELPTITDESVNDGAKYMYITSNNTIYGTRYKTFPKLKKAPLIADMTSELLSRKLPIEDFSVIFAGAQKNIGPSGLTLVIYDKEKLPEVSHPIPNLMNFALMEKNGSLYNTPPTYSIYIAGLVFKYLKRKGGLAVMEETNERKAKKLYDAIDSSSLFYAPVPVPFRSAMNVVFRSHNDGLDSKFLSLAEEQGFAGLKGYREVGGFRASIYNAMPEEGVDALISFMKEFERSNG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_YERPY
Sequence: MIRTMLQGKLHRVKVTQADLHYEGSCAIDQDFLEAAGILEYEAIDIYNVDNGQRFSTYAIAAERGSRIISVNGAAARCACVGDKLIICSYVQMSDAAARLHHPKVAYFEGENQLQRKAKAVPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_SHEAM
Sequence: MLKKTMNIADYDPELFKAIEDETLRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVETLAIERAKELFGATFANVQPHSGSQANSAVYMTLLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIIPYGIDETGKIDYDEMERLAVEHKPKMMIGGFSAYSGIVDWARMREIADKIGAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTSTTHKTLAGPRGGIILSAANDEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKVYQQQVVTNAKAMVEVFLERGYKIVSGGTDNHLMLVDLIGRDLTGKEADAALGAANITVNKNSVPNDPRSPFITSGIRIGTPAITRRGFKEAEARELTHWICDVLDNAKDESVIARVKGQVLELCARFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_PHOLL
Sequence: MAKNIQAIRGMNDYLPADTVIWQRIETILKRVLAGYGYSEIRTPIVEQTPLFRRAIGEVTDVVEKEMYTFDDRNGESVTLRPENTAGCVRAGIEHGLLYNQEQRVWYLGPMFRYERPQKGRYRQFYQLGAEVFGLQGPDIDAELILLTARWWRELGIFEHVTLELNSIGSLAARANYREALVAFLEQHQDKLDEDCKRRMYSNPLRVLDSKNPEVQQLLNDAPELCDYLDAESKEHFDGLCALLDGAGIKYRINQRLVRGLDYYNRTVFEWVTTALGAQGTVCAGGRYDGLVEQLGGRPTPAVGFAMGMERLILLVQEINPAFVAERTVADVYLASFGEGSQQAALILAEQVRDTLPQLRLMMNHGGGNFKKQLGRADKQGAKIALILGEDEVRSGQVAIKDLRTGEQQTLPQSEIAARLVELLS
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPAN1_BP933
Sequence: MNRVLCVVIIVLAVGYGALWLATNHYRDNALTYKAQRDKKARELEQANATITDMQVRQRDVAALDAKYSRELADARAENETLRADVAAGRKRLRINATCSGTVREATGTSGVDNATGPRLADTAERDYFILRERLITMQKQLEGTQKYINEQCR
What is the function of this protein?
Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit.  The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin have permeabilized the inner membrane and degraded the host peptidoglycans.  Host outer membrane disruption is due to local fusion between the inner and outer membrane performed by the spanin complex.
What are the official names of this protein?
Spanin, inner membrane subunit, i-spanin, Lysis protein Rz.
What is the protein family that this protein belongs to?
Belongs to the Lambdavirus i-spanin family.
What are the subcellular locations of this protein?
Host cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: HSLO_HALH5
Sequence: MGDYLVKALGFEGKVRAYALKATEMVNEAVRRQDTWPTASAALGRTMMAGTMMAAMLKGDAKLTVKVEGDGPIGAIIVDSQANGQTRGYVKNPHVHFELNEHGKLDVARAVGTNGSLSVVKDIGLRDHFTGSVPLVSGELGEDFTYYFVSSEQTPSSVGVGVLVNPDNSVLAAGGFVLQLMPGADDAIISEIEKRLQTIPPISKLVEAGMPPEEILAALLGDDNVKILEKMPIEFACQCSKERIARAIISLGKDEIRAMIEEDGGAETTCHFCNEVYLFSKEELETLYEEA
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
Protein: OPSG_MOUSE
Sequence: MAQRLTGEQTLDHYEDSTHASIFTYTNSNSTKGPFEGPNYHIAPRWVYHLTSTWMILVVVASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWVWAAIWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYAFHPLVASLPSYFAKSATIYNPIIYVFMNRQFRNCILHLFGKKVDDSSELSSTSKTEVSSVSSVSPA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.  May increase spectral sensitivity in dim light.
What are the official names of this protein?
Medium-wave-sensitive opsin 1, Green cone photoreceptor pigment, Green-sensitive opsin, M opsin, Medium wavelength-sensitive cone opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FSHB_MOUSE
Sequence: MMKLIQLCILFWCWRAICCHSCELTNITISVEKEECRFCISINTTWCAGYCYTRDLVYKDPARPNTQKVCTFKELVYETVRLPGCARHSDSLYTYPVATECHCGKCDSDSTDCTVRGLGPSYCSFSEMKE
What is the function of this protein?
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer.  Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity).  Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:9020850, PubMed:11416011).
What are the official names of this protein?
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted. Note=Efficient secretion requires dimerization with CGA.
Protein: RL16_PSEA6
Sequence: MLQPKRMKFRKMHKGRNRGYAAGDSVSFGTFGLKSVGRGRMTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLEVRQGKGKGNVEYWVCQIQPGRVLYEMEGVPESVAREAFELAASKLPFKTTFVTRTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: CEP72_HUMAN
Sequence: MARAGPRLVLSEEAVRAKSGLGPHRDLAELQSLSIPGTYQEKITHLGHSLMSLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNCISSLAEVFRLHALTELVDVDFRLNPVVKVEPDYRLFVVHLLPKLQQLDDRPVRASERKASRLHFASEDSLDSKESVPASLKEGRPHHPRAKCTEALAKQSLVMDADDEAVLNLIAECEWDLGRPPGSTSFSQKGREADSRGSQESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAPRPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTLSQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVGEDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHLLQELSQVRAQHRAEVEQMHWSYQELKKTMALFPHSSASHGGCQAC
What is the function of this protein?
Involved in the recruitment of key centrosomal proteins to the centrosome.  Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids.  Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135).  Involved in centriole duplication.  Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).
What are the official names of this protein?
Centrosomal protein of 72 kDa, Cep72.
What is the protein family that this protein belongs to?
Belongs to the CEP72 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.
Protein: BPPS_SALOF
Sequence: MSIISMNVSILSKPLNCLHNLERRPSKALLVPCTAPTARLRASCSSKLQEAHQIRRSGNYQPALWDSNYIQSLNTPYTEERHLDRKAELIVQVRILLKEKMEPVQQLELIHDLKYLGLSDFFQDEIKEILGVIYNEHKCFHNNEVEKMDLYFTALGFRLLRQHGFNISQDVFNCFKNEKGIDFKASLAQDTKGMLQLYEASFLLRKGEDTLELAREFATKCLQKKLDEGGNEIDENLLLWIRHSLDLPLHWRIQSVEARWFIDAYARRPDMNPLIFELAKLNFNIIQATHQQELKDLSRWWSRLCFPEKLPFVRDRLVESFFWAVGMFEPHQHGYQRKMAATIIVLATVIDDIYDVYGTLDELELFTDTFKRWDTESITRLPYYMQLCYWGVHNYISDAAYDILKEHGFFCLQYLRKSVVDLVEAYFHEAKWYHSGYTPSLDEYLNIAKISVASPAIISPTYFTFANASHDTAVIDSLYQYHDILCLAGIILRLPDDLGTSYFELARGDVPKTIQCYMKETNASEEEAVEHVKFLIREAWKDMNTAIAAGYPFPDGMVAGAANIGRVAQFIYLHGDGFGVQHSKTYEHIAGLLFEPYA
What is the function of this protein?
Catalyzes the formation of the (+)-camphor precursor (+)-bornyl diphosphate from geranyl diphosphate.  The enzyme also produces significant amounts of (+)-alpha-pinene, (+)-camphene, and (+-)-limonene.
What are the official names of this protein?
(+)-bornyl diphosphate synthase, chloroplastic, BPPS, (+)-alpha-pinene synthase, (+)-camphene synthase, SBS.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FGF19_HUMAN
Sequence: MRSGCVVVHVWILAGLWLAVAGRPLAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEPEDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK
What is the function of this protein?
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades.  Stimulates glucose uptake in adipocytes.  Activity requires the presence of KLB and FGFR4.
What are the official names of this protein?
Fibroblast growth factor 19, FGF-19.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: CARB_RUBXD
Sequence: MPRRDDIRSILIIGSGPIVIGQAAEFDYSGTQACRALKEEGYRVILVNSNPATIMTDPEMADTTYIEPLRAETVAEVIRRERPDALLPTLGGQTALNLAVELSEAGVLEEYGVQLLGASIPSIQKAEDRQLFREAMERIGLRVPESRTVRSVPEAEELAERIGFPLIIRPSFTLGGTGGSVAEDLDALRASVRDGLDASPVRSVLVERSVAGWKEFELEVMRDLADNVVIVCSIENVDPMGVHTGDSITVAPAQTLSDRQYQSLRTAAIRIIREIGVSTGGSNIQFAVNPEGDDFYVIEMNPRVSRSSALASKATGFPIAKIAARLAVGYTLDEITNDITGATPASFEPALDYVVTKIPRFAFEKFPGTSARLTTRMHSVGEVMAIGRTFTESLLKAMASLEIETRDIQARLDEPSPYRIFAVFEALRAGMDIPEIYRRTSIDPFFIAAAARIVAAEGAVEETLSAEQVRELKRMGFTDEALAACSGYPAEVVRGVRRALGVHPTYKAVDTCAGEFPARTPYYYSTYEQEDEVERGENPSVVVLGSGPNRIGQGIEFDYACVHASYELKACGYDAVMINSNPETVSTDYDTSSRLYFEPLTAEHVLEVVRRERPEGVILQFGGQSPLKLARELERAGARVLGTSPEAIDLAEDRSRFGRLLRELGIPHPRFGTATTAAEAREVARRLGYPVVVRPSYVLGGRRMEIVYGDEDLELYLRSSVSGSPEHPILVDKFMEAYVEVDVDAVSDGEEVYIGGIMEHIEEAGVHSGDSSCVTPPITLTRSLQERIEDYTRRLALSIGVVGLMNVQYVVRGDEVMAIECNPRASRTVPYISKATGVPLARLATRVLLGEKLRDLGPRPASSGSFAVKAPVFPFDRFAEVDPLLGPEMRSTGEAMGIDPTFGGAFAKALAAAGQRLPESGRVYVSVADRDKRAAVLIARGFADLGFEVLASEGTAGVLRNNGLPAAVVPKIGEGGEDVLGLIERGGVDLIVNTPWGRGSRTDGYLIRRKALMHRVPCITTLAGAAAALQGIEARIRGETRRVHSLQDLYAART
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: OBG_BRUSU
Sequence: MKFLDQAKIYIRSGNGGAGAVSFRREKFLEFGGPDGGDGGRGGDVWVEAVDGLNTLIDYRYQQHFKAKTGMHGMGRNMTGGKGDDVVLRVPVGTQIFEEDNETLICDITEVGQRYRLAKGGNGGFGNLHFTTSTNRAPRRANPGQEGIERTIWLRLKLIADAGLVGLPNAGKSTFLASVTAAKPKIADYPFTTLHPNLGVARIDGREFVIADIPGLIEGASEGVGLGDRFLGHVERTRVLLHLVSAQEEDVAKAYQVIRGELEAYEHGLADKPEIVALSQVDTLDPETRKAKVKALKKACGCEPLLLSAVSHEGLNDTLRQLARIIDLSRAEEAGTAQAEE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSN_TERTT
Sequence: MSHQSELIETDIDAYLAQHERKELLRFLTCGSVDDGKSTLIGRLLHDSKMIYEDQLAAVASDTTKHGTTGEKIDLALLVDGLQAEREQGITIDVAYRYFSTAKRKFIIADTPGHEQYTRNMATGASTCDLAVILIDARYGVQTQTRRHSYIASLLGIKHVVVAINKMDLVEFSESRFEEIKQSYLDLSKSLNPAELHFVPMSALDGDNVVNISERTPWYSGKSLMQILETVEIASDKNADDFRFPVQFVNRPNLNFRGFCGTVASGVVKVGDKVKALPSGKTSTVKSIVTFDGELDEAFVGQAVTLTLADEIDISRGDMVVLADSEQTLSNRLRAHLVWMSEAELKPGKQYLFKFASKVTPGVVADIEYRVDVNTFEKSEESAMQLNDIAVVDVQLEQEVVVDAYQKNRATGAFIVIDRLTNITVGAGMAIEALASAAATKGDYSEFEVELNALVRKHFPHWDAKKIG
What is the function of this protein?
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 1, ATP-sulfurylase large subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.