PharMolix/UniProtQA huggingface dataset:
Protein: SYS_SODGM
Sequence: MLDPNLLRNELDAVAEKLARRKFKLDVATLRQHEERRKVLQVETENLQAERNARSKAIGAAKSRGEDIEPLRREVNQLGERLSSAKTELDALQSEIRDYAFSLPNIPDDDVPDGRDENDNQEVSRWGEPRQYDFPIRDHVELGEIAGGLDFAAAVKLTGARFVVMRGQIARLHRALTQFMLDLHTEQHGYVEHYLPYLVNHASLYGTGQLPKFVEDLFHTQPLNEEADTSAYALIPTAEVPLTNLIRDEIIEEDALPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQVVKPAQSMQALEEMTSHAEKVLQLLQLPYRKVLLCNGDMAFASCKTYDLEVWLPAQNTYREISSCSNISDFQARRMQARYRSRTDKKPQLVHTLNGSGLAVGRTLVAVLENHQLADGRIAIPAVLQPYMKGLTHIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_ASPFU
Sequence: MSNEQTFIAIKPDGVQRGLIGPIISRFENRGFKLVAMKLVSPPQSQLEQHYADLSDKPFFKGLVSYMLSGPICAMVWEGRDVVKTGRTILGATNPLASAPGTIRGDFAIDVGRNVCHGSDSVENAKKEIALWFKPEELISWKSATFDWVYEKA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
Protein: NNRE_DROWI
Sequence: MLKYLNQAEAIKVDQILFNEYKFSVDQLMELAGLSCAHAVAKCFPSPCQGNDDKAGKLRVLVCCGPGNNGGDGLVCARHLALMGYEPTIYYPKPTAKPLYENLHHQCELMEISTISQCPSVEEAAHSYHLIVDALFGFSFKPPVRSDFLSVMELMQQTKIPIASIDIPSGWDVEKGKLNDCELEPKLLISLTAPKLCAKHFKGQYHYLGGRFVPPALQRQYELNLPNYPGTELCVKLS
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
Protein: RS11_BUCBP
Sequence: MVKELIRVKKRVKKQILDGIAHIHASFNNTIISISDKKGNVLGWATSGGSGFRGSRKSTPFAAQVAVERCADIVKSYGIKNLEVMVKGPGPGRESSIRTLNTIGFRIINITDVTPIPHNGCRSPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: BTUC_PECAS
Sequence: MQLPHYSQLKQQQCRRDRRSLALLLAFLVLTLVVSLCAGERWIWPTAWLDDAQQLFVWQLRLPRTLAVMLVGASLAMSGTVMQAVFDNPLAEPGLLGVANGAGVALVLTVLLGQGLLPVWVLSLSAIAGALLITFLLLHFARRHISNTRLLLIGIALGIICSAVMTWAVYFSTSLDLRQLMYWMMGGFSGIDWRHGWLMLTLLPLLLWLSRQGTVLNGLTLGEIQARQLGIPVYRWRTVLVLVMGVQVGLSVALAGIIAFIGLIIPHMLRLCGLTDQRYLLTGCALAGGGVLLLADTVARVALNSAELPIGVVTATQGSPWFIWLLLRNRL
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Involved in the translocation of the substrate across the membrane.
What are the official names of this protein?
Vitamin B12 import system permease protein BtuC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: M2_I96A3
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGIVHLILWIIDRLFSKSIYRIFKHGLKRGPSTEGVPESMREEYREEQQNAVDADDGHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: COBQ_HERAR
Sequence: MKFPFPTLMVQGTTSDAGKTTLVAALCRLLAQQGVRVVPFKPQNMALNSAVTADGGEIGRAQALQAVAAGLPPHTDMNPILLKPSSDTGAQVIIHGRARNDMNARDYHAYKPIAMQAVLESYGRLSAQYETVLVEGAGSPAEVNLRDRDIANMGFAEAVDCPVILVADIDRGGVFAHIIGTLACLSESERKRTIGFVINRFRGDISLLEPGLRWLEEQTGKPVLAVLPYLHGLFLDAEDAVEQTQTARGAFRIVVPVPPRISNHTDFDALRAHPDVDLQLIGPGQPIPAADLIILPGSKNTRGDLDWLIANGWREALIRHARYGGKIIGICGGYQMLGKTIADPQGVEGLPGISQGLALLDITTVLTPEKQLEQVHGMCAFADTDAAVSGYEIHMGLSEGEACSHPAFVIAGRPEGARSADDQILGSYLHGMFDTPSACSALLRWAGLDSDVAVDTARLREASLDRIAQAAQPLLDALCALDPPTA
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: HYOU1_RAT
Sequence: MAATVRRQRPRRLLCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATLRYFQHLLGKQADNPHVALYRSRFPEHELNVDPQRQTVRFQISPQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQNIMFYDMGSGSTVCTIVTYQTVKTKEAGTQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQRKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFDRVPGPVQQALQSAEMSLDQIEQVILVGGPTRVPKVQEVLLKPVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPILVEFTREVEEEPGLRSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGSKDEPAEQGELKEEAEAPMEDTSQPPPSEPKGDAAREGETPDEKESGDKSEAQKPNEKGQAGPEGVPPAPEEEKKQKPARKQKMVEEIGVELAVLDLPDLPEDELAHSVQKLEDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKDKLAELRKLCQGLFFRVEERRKWPERLSALDNLLNHSSIFLKGARLIPEMDQIFTDVEMTTLEKVINDTWTWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRTEPPLNASAGDQEEKVIPPTGQTEEAKAILEPDKEGLGTEAADSEPLELGGPGAESEQAEQTAGQKRPLKNDEL
What is the function of this protein?
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation.  May play a role as a molecular chaperone and participate in protein folding (By similarity).
What are the official names of this protein?
Hypoxia up-regulated protein 1, 150 kDa oxygen-regulated protein, ORP-150.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: OMA1_SCHPO
Sequence: MFLNKYISNYSRTRAVSCAPVLSYKKCSYRNFNGLLQARFQSNNLSWSNRNRVVYKSFQPNPRDKRFQWIFGALIAGGGVYYFTHLEYVPISNRRRFNDVSLDFEKRMAQDAYKEVMSEYGDRMLPSYHPTTLYVSRVLKRIIAVSGMSDLKWELHVIRDPTPNAFVLPGGKVFVFEGILPMCKGEDGLAAVLAHETAHQVARHSAEKIAFTRAVSCIVFLAAASLDLSGQLSHFLLNFGLLLPFSRKMETEADYIGLMLMSQACFDPNAAKTLWERMDAAEGQMGKALAFASTHPSSKKRIRKIEEWLPEAQVKRETSDCYHETWPMLQSFKEVHW
What is the function of this protein?
Protease that is part of the quality control system in the inner membrane of mitochondria.  Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane protein.
What are the official names of this protein?
Mitochondrial metalloendopeptidase OMA1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: HFQ_RHOP2
Sequence: MAADRAQNLQDTFLNHVRKTKTPLTIFLVNGVKLQGIVTWFDNFCLLLRRDGHSQLVYKHAISTIMPGAPIQLFEGGEDSPA
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: AROB_CAUVN
Sequence: MIRTVPVGLGERAYDVVIGPGLLDQAGERVAAVLGKRKRVAVVTDAHVGAHHGERLSAALQGAGITVDLITIAPGEESKSFEGLADLSDRLLALNLERGDQIVALGGGVVGDLAGFAAAIYKRGIDFVQVPTTLLAQVDSSVGGKTAIDTPRGKNLIGAFHQPRLVLADLDVLATLPARELACGYAEIIKYGLLGDFAFFEWLETNVQAVLDRDVDALVRAVGRSVEMKAEIVAEDEKEAGRRALLNLGHTFGHAIEAEMGFGEALKHGEAVGVGMAQAFRFSARLGLCPSQDAVRAQAAIKAAGLPTTLADVRPEPFSADALIAHCGQDKKAQGGKLTFVLARGIGDAFVAKDVDRAALKAFLVEEGAV
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_BACMK
Sequence: MTQYTPMIQQYLKVKADYQDAFLFFRLGDFYEMFFEDAVKAAHELEITLTSRDGGSSERIPMCGVPHHAAKNYIEQLVEKGYKVAVCEQVEDPKTAKGVVRREVVQLITPGTMMEGRTIDEKENNFLAALTHFEDGSYALACNDLTTGQNTVTLLTGSVEDILLEVYATGSKEIVVDSTFSKDELNKLTETLKMTISYEDTTTIPEGLEHLVKSVSQAKLIKAIGRLFNYVIRTQKRSLDHLQPVEIYYTNQFMKIDVHSKRNLELTETLRTKEKTGSLLWLLDKTKTAMGGRMLKQWMERPLIQKEKVEERLEMVETFVNDYFLREDLKEKLKEVYDLERLAGKVAFGNVNARDLLQLRRSLLQVPAILEAISLLDNAYAARLIQGADPCESLTELLGRSIQENPPLSIKDGDIIKDGYNDKLDQYRYVSKNGKTWIAELEKRERDITGVKSLKIGYNRIFGYYIEVTKANLGALPEGRYERKQTLANAERFITDELKEKETLILEAEEKIVQLEYDLFTALREEVKVFIPKLQHLAKVISELDVLQSFATVSEEEQFVKPVLTNKREIFIKDGRHPVVEKVLNGKLYVPNDCIMPEKMDVFLITGPNMSGKSTYMRQLALVTVMSQIGCFVPATEAVLPVFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIANASERSLILFDEIGRGTSTYDGMALAQAIIEHIHDQIGAKTLFSTHYHELTVLEESLDQLKNVHVSAIEENGKVVFLHKIQDGAADKSYGIHVAQLAELPESLIARAKEVLAQLEGQEEIVIPKRVEVKVPEVAPEPVVVKEEPAEIQETKVETEEESQLSFFGGEQSSKKQDKSVLDAKETAVLAQIKKIDLLDMTPLEAMNELYRLQKKLKKG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: SECA_POLAQ
Sequence: MVIGLLKTLVGSRNDRLLKQYRKVVAKVGTFEANLQTLDDAALAAKTDEFKSRLASGESLDSIAPEAFAVVREASVRVMKMRHFDAQLMGGLALHQGKIAEMGTGEGKTLTATLPVYLNALTGKGVHVVTVNDYLAQRDAEWMSTLYNFLGMKVGVNLSQMDHTTKKEAYAADITYGTNNEFGFDYLRDNMVQDLEQRVQRGLAYAIVDEVDSILIDEARTPLIISGQADDHTDLYIKINALPSHLELQIGEEKSDGTGVEKPGDYWVDEKSQQVYLTERGHDKAEEVLVQLGALDDGASLYAPQNITLMHHVYAALRAHTLYHRDQQYVVQNGEVIIVDEFTGRLMQGRRWSDGLHQAVEAKEGVAIQNENQTLATITFQNYFRMYGKLAGMTGTADTEAYEFKEIYNLETVVIPPNRISQRKDKQDQIYKSSRERYDAVIKDIEDCYQRGQPVLVGTTSIENSELIAGLLDKRKLPHQVLNAKQHAREAEIIAQAGRPKMITIATNMAGRGTDIVLGGNVGKQSSLIQVDEALSDLEKAAKIKSLQDEWQSIHDQVLTAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSLDDPLLRIFAGDRLRAVMERLKMPDGEPIEAGMVTRSIESAQRKVEGRNFDIRKQLLEYDDVANDQRKETYRLRNEVLESADIGELIANLREDVLRTICSIYVPLESMEEQWDLAGLEHALASEWGLKVDLQKWVEGSDSVDDVEIVDRVLEAAKESYDAKVDLSGRQSFAGFERSVLLYSVDTHWREHLAALDHLRQGIHLRGYAQKDPKQEYRREAFELYGELLNVIKNDVVKNIMTVEIRSASELDQAAESMNEDLAKLSDVQYQHADPDMEVAGSTGDRGAALDIQPAPVRSGPKIGRNDPCSCGSGKKYKNCCGALS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: OBG_EHRCJ
Sequence: MSFIDEAKIYLKAGNGGDGCSSFRREKFIEFGGPDGGNGGNGGNIIFYTSHHINTLLYFRYKQHIKAENGNPGSSKKKSGSSGKDVIIKVPIGTQLYDEDGMLITDLNEENQKFIAAHGGKGGIGNANYKTSTNRAPRHFTFGKRGEEKHIILKLKIISDVGIIGLPNAGKSSFLASCTNSKTKIADYPFTTLEPHLGVAFIDNTELVLADIPGLIPGAHLGHGIGDKFLKHIERCSILLHIIDCTLDNIIESYECIRKELSFYNKELSNKTEFIVLNKSDLLDKKEINQKKQILSNHTKKEIFISSIKNNRYPILSTLIKQIHKKYTNTKPHIYDPFNI
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_STRPQ
Sequence: MMKRQFEDVTRIVIKIGTSSLVLPTGKINLEKIDQLAFVISSLMNKGKEVILVSSGAMGFGLDILKMEKRPTNLAKQQAVSSVGQVAMMSLYSQIFAHYQTNVSQILLTRDVVVFPESLANVTNAFESLISFGIVPIVNENDAVSVDEMDHATKFGDNDRLSAVVAGITKADLLIMLSDIDGLFDKNPTIYEDAQLRSHVAVITQEIIASAGGAGSKFGTGGMLSKIQSAQMVFENKGQMVLMNGANPRDILRVLEGQPLGTWFKQIEEVRHD
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYO5B_RAT
Sequence: MTYSELYSRYTRVWIPDPDEVWRSAELTKDYKDGDESLQLRLEDDTILDYPIDVQNNQVPFLRNPDILVGENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISIFKIIASILHLGSVEIQAERDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARNALAKHIYAQLFSWIVEHINKALQTSLKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYERHSNSQHFQKPRMSNTAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFRDDEDSVPATNTAKSRSSSKINVRSSRPLMKAPNKEHKKSVGYQFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLMKKRELANTTDKKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMIQKTVRGWLQRVKYRRLRAATLTLQRFCRGYLARRLTEHLRRTRAAIVFQKQYRMLKARRAYCRVRRAAVIIQSYTRGHVCTQKLPPVLTEHKATIIQKYARGWMARRHFQRQRDAAIVIQCAFRRLKARQALKALKIEARSAEHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQLSAVTSTHAMEVEKLKKELARYQQNQEADPSLQLQEEVQSLRTELQKAHSERRVLEDAHNRENGELRKRVADLEHENALLKDEKEHLNHQILRQSKAESSQSSVEENLLIKKELEEERSRYQNLVKEYSQLEQRYENLRDEQQTPGHRKNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGIEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKEQQDSKKVQVEQQNNGLDVDQDADIAYNSLKRQELESENKKLKNDLNERWKAVADQAMQDNSTHSSPDSYSLLLNQLKLANEELEVRKEEVLILRTQIMNADQRRLSGKNMEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNSQTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQNLKHEEEVEHLKAQVEAMKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNEKKLKKQLKIYMKKVQDLEAAQALAQSDRRHHELTRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLSSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVRPTGYRKRSSSMVDGENSYCLEAIIRQMNFFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACSWSTGMQLRYNISQLEEWLRGKNLQQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNGFEERVTVSFIRTIQAQLQERSDPQQLLLDSKHMFPVLFPFNPSALTMDSIHIPACLNLEFLNEV
What is the function of this protein?
May be involved in vesicular trafficking via its association with the CART complex.  The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.  Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane.  Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells.  Together with RAB11A and RAB8A participates in epithelial cell polarization.  Together with RAB25 regulates transcytosis.  Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes.
What are the official names of this protein?
Unconventional myosin-Vb, Myosin heavy chain myr 6.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_ACHLI
Sequence: MIHAIGTDLVELERIKSIGIDRFKDKILNEDEKNEYAKINHENRKLTYLAGRFAVKESLFKCFKAGDKTANYKDFSVLNDSVGAPYVVSKHTSDFVVHITISHTNLYAIAFVVLETKV
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_MYCBP
Sequence: MSRIGKQPIPVPAGVDVTIEGQSISVKGPKGTLGLTVAEPIKVARNDDGAIVVTRPDDERRNRSLHGLSRTLVSNLVTGVTQGYTTKMEIFGVGYRVQLKGSNLEFALGYSHPVVIEAPEGITFAVQAPTKFTVSGIDKQKVGQIAANIRRLRRPDPYKGKGVRYEGEQIRRKVGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: LOVHK_BRUME
Sequence: MAIDLRPFIPFGRGALSQATDPFRAAVEFTLMPMLITNPHLPDNPIVFANPAFLKLTGYEADEVMGRNCRFLQGHGTDPAHVRAIKSAIAAEKPIDIDIINYKKSGEAFWNRLHISPVHNANGRLQHFVSSQLDVTLELSRLVELEKERKTLSIETARSKDQLDYIVEVANIGFWTREFYSGKMTCSAECRRIYGFTPDEPVHFDTILDLVVLEDRMTVVQKAHQAVTGEPYSIEYRIVTRLGETRWLETRAKALTGENPLVLGIVQDVTERKKAEANKALVSREIAHRFKNSMAMVQSIANQTLRNTYDPEQANRLFSERLRALSQAHDMLLKENWAGATIQQICATALAPFNSTFANRIHMSGPHLLVSDRVTVALSLAFYELATNAVKYGALSNEKGVINITWAIMEDKGEKKFHMRWAESRGPEVMQPARRGFGQRLLHSVLAEELKAKCDVEFAASGLLIDVLAPITPEVFPGMGHNVPEQRIA
What is the function of this protein?
Photosensitive kinase that is involved in increased bacterial virulence upon exposure to light.  Once ejected from an infected animal host, sunlight acts as an environmental signal that increases the virulence of the bacterium, preparing it for infection of the next host.  This photoreceptor protein is directly related to the bacterium's survival and replication within host macrophages.
What are the official names of this protein?
Blue-light-activated histidine kinase, BM-LOV-histidine kinase, BM-LOV-HK.
Protein: PRSA_LACLC
Sequence: MKKKMRLKVLLASTATALLLLSGCQSNQTDQTVATYSGGKVTESSLYKELKQSPTTKTMLANMLIYRALNHAYGKSVSTKTVNDAYDSYKQQYGENFDAFLSQNGFSRSSFKESLRTNFLSEVALKKLKKVSESQLKAAWKTYQPKVTVQHILTSDEDTAKQVISDLAAGKDFAMLAKTDSIDTATKDNGGKISFELNNKTLDATFKDAAYKLKNGDYTQTPVKVTDGYEVIKMINHPAKGTFTSSKKALTASVYAKWSRDSSIMQRVISQVLKNQHVTIKDKDLADALDSYKKLATTN
What is the function of this protein?
This protein is essential for production of active forms of the serine proteinase located in or secreted from the cell envelope.
What are the official names of this protein?
Foldase protein PrsA, Protease maturation protein PrtM.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ANMK1_JANSC
Sequence: MAGKEKAVWPPVWAAGAMSGTSFDGVDVALLLTDGVRIEAFGDAREVAYSDADRAILREAMGAWPGEARAEVAAQVVEAAHITAMVDLPDVALLGFHGQTLAHDPEARRTHQVGDGAVLANALGVEVIWDFRSADMGLGGQGAPLAPFYHWACARWIGAQGPVAILNLGGVGNITWVDPSIEGPELPGACLAFDTGPANAPIDDLMVRRGLGACDVGGALAARGEIDLKILEEALEAPWFDLAPPKSLDRDAFSGLADAVSGLSDADASATLTAVSAGAVARGLAHLSSRPRQVLVAGGGRKNATLMAMVQDALGCDVRAVEDVGLNGDALEAQAFAYLAVRVARGLPTSAPSTTGVAAPVGGGRRSKPGARELS
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase 1, AnhMurNAc kinase 1.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: PYRR_HAEI8
Sequence: MEKIIIDHDRFLRTISRISHEIIEKHQTLDDLVIVGIKRRGAEIAELLQRRVEELSGINLPSMELDITFYRDDLTLVDQEDKMPVYSGSSQYLNIQDKTVILVDDVLFTGRTIRAAMDALTDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRDELVQVRTEKQDGCYEVAILGK
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: SHC2_HUMAN
Sequence: MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP
What is the function of this protein?
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons.  Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
What are the official names of this protein?
SHC-transforming protein 2, Protein Sck, SHC-transforming protein B, Src homology 2 domain-containing-transforming protein C2, SH2 domain protein C2.