PharMolix/UniProtQA huggingface dataset:
Protein: THIE_CAMJ8
Sequence: MKNKLDLSLYLVASQGNKSEECFLNTLENAIKGGVSIIQLREKELNAREFYKLGLKVQKLCKAYKIPFLINDRVDIALALDADGVHLGQEDLEVKLARKLLGDEKIIGLSLKKLEQLEFIQGANYLGCGAIKATPTKESSLLSLELLSQICDKSPIGVVAIGGVDKAVLDELKGINLSGVAVVRAIMDAKDAFLAAKELKRKIYENLPLK
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: TEKT3_RAT
Sequence: MEPLGSTLTATYAHPQPAATNFLPAIGTLTSSYRNRFPHRNLTHSLSLPWRPSTYYKTAYNYPTLAPLSSTSQSVCESTMLPFVSNRTTLFTRYTPDDWYRSTLVGFQESNCSRHNSERLRVDTSRLIQDKYQQIRKTQADSTQNLGERVNDIAFWKSEIIHELDEMIGETNALTDIKRRLERGLIETDAPLQVARECLFHREKRMGIDLVHDEAEKELLTEVETVLCCQERMRRHLDKAIAQLASDRSAQHELEKDLSDKQAALRIDDKCKHLRNTSQGVSYFRGVENVDATVSVPESWAKFTDDNVLRSQSERAASAKLREDTENLLIVIANEMWNQFNKVNVAFTNRIAETVDAKNKIHIHLSKTLQEIFQTEMAIESIRKAIKEKSAFLKVAQTRLDERTRRPNIELCRDIAQLRLVNEVYEVDETIQTLQQRLRDSEDTLQSLAHTKATLEHDLAVKANTLYIDQEKCMSMRNSYPSTLRLVGFC
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme.  Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).  Required for normal sperm mobility (By similarity).
What are the official names of this protein?
Tektin-3.
What is the protein family that this protein belongs to?
Belongs to the tektin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane; Peripheral membrane protein. Note=In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (PubMed:21744413). Not detected in the central axonemal region of the flagellum (PubMed:21744413). Associates with the acrosome membrane in the equatorial segment of the sperm head (PubMed:21744413). Also detected just below the plasma membrane in the post-acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (PubMed:21744413). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity).
Protein: METAS_CROS8
Sequence: MPIRVPDELPAVNFLRQENVFVMTTSRASVQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIRLLRIDSRESRNTPAEHLNNFYCNFEDICDENYDGLIVTGAPLGLVEFNDVAYWPQIQQVLEWAKEHVTSTLFVCWAVQAALNILYGIPKQTRQEKISGVYEHHITQPHALLTKGFDDTFLAPHSRYADFPAALIRDYTDLDILAESEEGDAYLFASKDKRIAFVTGHPEYDALTLAGEYFRDVEAGLAPRVPYNYFPNNDPTKTPRATWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLE
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_INBAA
Sequence: MVVTSNADRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPKCLNCTDLDVALGRPKCMGTIPSAKASILHEVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTHNVINAEAAPGGPYIVGTSGSCPNVTNGNGFFATMAWAVPKNNNNKTATNPLTVEVPFICTEGEDQITVWGFHSDDETQMVKLYGDSKPQKFTSSANGVTTHYVSQIGGFPKQAEDGGLPQSGRIVVDYMVQKSGKTGTITYQRGILLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKE
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: UBIC_ACIAD
Sequence: MQKIQSNQIQEQDLTPELKKWLYASGSLTQQLTDLADGLFTVEPIQEKYQRMSFMDSRWMRMPAYHVAWVRESLLYGCEQQPWVKAKSIFPVLSLQKKARIFKHIGKKPIGRFLFQRTTPLCERRVIRLEEGWTRQSCYTWHGCKFIVQETFLASFEQYIQHHSHSI
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPK4_PACBA
Sequence: AELPQGLWVRPRLG
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-4, PK-4.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL34_NOCFA
Sequence: MAKGKRTFQPNNRRRARVHGFRLRMRTRAGRAIVSARRRKGRATLTA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PG163_MONPV
Sequence: MDAAFVITPMGVLTITDTLYDDLDISIMDFIGPYIIGNIKIVQIDVRDIKYSDMQKCYFSYKGKIVPQDSNDLARFNIYSICTAYRSKNTIIIACDYDIMLDIEGKHQPFYLFPSIDVFNATIIEAYNLYTAGDYHLIINPSDNLKMKLSFNSSFCISDGNGWIIIDGKCNSNFLS
What is the function of this protein?
Mildly affects the expression of MHC class II molecules on the surface of host antigen presenting cells (APCs).
What are the official names of this protein?
Protein OPG163.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG163 family.
Protein: Y4317_ARATH
Sequence: MANSTGKPTSSTQEDEEATSATEILAQLMQDIIDREEDIDDEDDIDDEVIDDEDYEVASLPLLQESQANQKQSREREEETEKNQPKRFKKQNMMKINIHDFSEETLRLIEVWYEAELDPQDIFGDNEVTRLFSRPIKKQLMSSDVDKDQCMLMLSKEQVKEKMLPFLEDSENPVKGIDVSVYGPDGKVQQMEFKMWNGDKTPVLTSGWKQFVEDYGLSMTCDFVTVWMFRHIKTRKLCFAIHYVKFSLRD
What are the official names of this protein?
Putative B3 domain-containing protein At4g03170.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYS_GRABC
Sequence: MHDIRALRADPAAFDAALGRRGLPASASSLLALDADRRMAQTRLQDYQARRNALAKEIGQGKRQGIDTSMLEATAVALRDEMEALEARSASLDAEQKSLLERLPNTLDAEVPTGPDESANVILKQVGEPISLPFSARQHFELGEALGMMLFDAAARLSGARFVVLRGALARLERALGQYMLDLHSTEHGFTEMQVPALVNDATAYGTGQLPKFTEDLFRTTDGRWLIPTAEVPLTNLVADSVVDEASLPMRMTALTDCFRSEAGSAGRDTRGMLRQHQFHKVEMVCITRPEDSDAEHERMTRCAETVLENLGLAYRRVFLCSGDTGFSAARTYDLEVWLPGQQAWREISSCSNCRDFQARRMSARYRGADGKVAGVPHTLNGSGVAVGRALIAVMETYQREDGSIDVPAVLRPYMGGLERISA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDEL_ECOLI
Sequence: MNSCDFRVFLQEFGTTVHLSLPGSVSEKERLLLKLLMQGMSVTEISQYRNRSAKTISHQKKQLFEKLGIQSDITFWRDIFFQYNPEIISATGSNSHRYINDNHYHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMKAGG
What is the function of this protein?
Acts both as an enzyme and as a c-di-GMP sensor to couple transcriptional activity to the c-di-GMP status of the cell (PubMed:26553851).  Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (PubMed:15995192, PubMed:24451384, PubMed:26553851).  Also acts as a transcription factor to control its own expression (PubMed:26553851).
What are the official names of this protein?
Cyclic di-GMP phosphodiesterase PdeL.
Protein: EI3JB_DANRE
Sequence: MADSDEWDADNFEPNEPIKIATAGRLDRWEGEDEEEDVKDNWDDEEEEKEEEKKVEQKIAEVKPPEKKKLSDKIKEKELLQKKKQEELKKNQETAASESLTLEEQLAEKARLKKLQEEADMELAREAFGVDPAAANASTTVNTTNASGIEAMCPSSKDDFVTFEKLLKEKITQFEKSVHYPSFLESLFRELCISLEVDDLKKISTSLSVLLTEKQKQEKEKKANKKKKKGVVPGGGLKANMKDDFADYGGFDGGYGNEYDDFM
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit J-B, eIF3j-B, Eukaryotic translation initiation factor 3 subunit 1-B, eIF-3-alpha-B, eIF3 p35-B.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit J family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESXA_STAAR
Sequence: MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ
What is the function of this protein?
Virulence factor that is important for the establishment of infection in the host.  EsxA is required for EsxB synthesis as well as secretion (By similarity).  Modulates host cell apoptotic pathways and mediates together with EsxB the release of S. aureus from the host cell.  By acting on apoptosis, plays a role in the modulation of dendritic cell-mediated immunity (By similarity).
What are the official names of this protein?
Type VII secretion system extracellular protein A, Ess extracellular protein A.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. sagEsxA-like subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the ESAT-6 secretion system (Ess) / type VII secretion system (T7SS).
Protein: PHNV_SALTI
Sequence: MLIWSPKGRAAAGVVASVLFIVFFFLPLAVILMSSLSQRWNGILPSGFTLNHFVNALHGAAWDALLASLTIGFCASLFALLCGVWAALALRQYGVKTQKWLSMVFYLPSAIPSVSVGLGILVAFSQGPLQMNGTLWIVLTAHFVLISAFTFSNVSTGLARISADIENVASSLGASPWYRLRHVTLPLLMPWMVSELALSLSLSMGELGATVMIYPPGWTTLPVAIFSLTDRGNIADGAALTIVLVAITLLLMMKLERIAKRLG
What is the function of this protein?
Probably part of the PhnSTUV complex (TC 3. A. 1. 11. 5) involved in 2-aminoethylphosphonate import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Putative 2-aminoethylphosphonate transport system permease protein PhnV.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FERM1_MOUSE
Sequence: MLSSGDLTSASWELVVRVDHANGEQQTEITLRVSGDLHIGGVMLKLVEQMNIAQDWSDYALWWEQKRCWLLKTHWTLDKCGVQADANLLFTPQHKMLRLRLPNAKTVRLRVSFSAVVFKAVADICKVLNIRRPEELSLLKPSSDYCKKKKKKEKNSKEPVIEDILNLESSSTSSGSPVSPGLYSKTMTPTYDPINGTPALSTMTWFGDSPLTEQNCSVLAFSQPPPSPDVLADMFQPRSLVDKAKMNAGWLDSSRSLMEQSIQEDEQLQLRFKYYTFFDLNPKYDAVRINQLYEQARWAVLLEEIDCTEEEMLIFAALQYHISKLSQCAEIQDFATKSEVDEVEAALSSLEVTLEGGKADNTLEDITDIPKLADYLKLFRPKKLMLKACKQYWFVFKDTSIAYFKNKELEQGEPIEKLNLRGCEIVPDVNVSGRKFGIKLLIPVADGMNEVYLRCDHEDQYARWMAACILASKGKTMADSSYQPEVISILSFLKMKNRNSSPLVASSLENMDMNPECLVSPCCAKKHKSKQLAARILEAHHNVAQMPLVEAKLQFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVAYNRLIRIDAVTGIPVTTWRFANMKQWNVNWEIRQVAIEFDQNVSIAFTCLSADCKIVHEYIGGYIFLSTRSKDQNETLDEDLFHKLTGGQD
What is the function of this protein?
Involved in cell adhesion.  Contributes to integrin activation.  When coexpressed with talin, potentiates activation of ITGA2B.  Required for normal keratinocyte proliferation.  Required for normal polarization of basal keratinocytes in skin, and for normal cell shape.  Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites (By similarity).
What are the official names of this protein?
Fermitin family homolog 1, Kindlin-1, Unc-112-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the kindlin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with filamentous actin. Constituent of focal adhesions (By similarity). Localized at the basal aspect of skin keratinocytes, close to the cell membrane (By similarity). Upon TGFB1 treatment, it localizes to membrane ruffles (By similarity).
Protein: ZHX1_HUMAN
Sequence: MASRRKSTTPCMVLASEQDPDLELISDLDEGPPVLTPVENTRAESISSDEEVHESVDSDNQQNKKVEGGYECKYCTFQTPDLNMFTFHVDSEHPNVVLNSSYVCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTINDLTFDGSFVKEENAEQAESTEVSSSGISISKTPIMKMMKNKVENKRIAVHHNSVEDVPEEKENEIKPDREEIVENPSSSASESNTSTSIVNRIHPSTASTVVTPAAVLPGLAQVITAVSAQQNSNLIPKVLIPVNSIPTYNAALDNNPLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKHGVSWTPEEVEEARRKQFNGTVHTVPQTITVIPTHISTGSNGLPSILQTCQIVGQPGLVLTQVAGTNTLPVTAPIALTVAGVPSQNNIQKSQVPAAQPTAETKPATAAVPTSQSVKHETALVNPDSFGIRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRNSKSNQCLHLNNDSSTTIIIDSSDETTESPTVGTAQPKQSWNPFPDFTPQKFKEKTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKKSKALKEEKMEIDESNAGSSKEEAGETSPADESGAPKSGSTGKICKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKNGNLKWYYYYQSANSSSMNGLSSLRKRGRGRPKGRGRGRPRGRPRGSKRINNWDRGPSLIKFKTGTAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRRSELGIELFEENEEEDEVIDDQEEDEEETDDSDTWEPPRHVKRKLSKSDD
What is the function of this protein?
Acts as a transcriptional repressor.  Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA.  May link molecule between DNMT3B and other co-repressor proteins.
What are the official names of this protein?
Zinc fingers and homeoboxes protein 1.
What is the protein family that this protein belongs to?
Belongs to the ZHX family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalized in the nucleus with DNMT3B.
Protein: FOLD1_PAEAT
Sequence: MTTEVLSGKPLAAIIQQRAHEETALLDDEGVRPVLAVVVATDDESTHWYVRSIERAAGRAGIGCRIIDLGHDATEQVLASVLADLSAEPTVHGIILQTPLPAAVRADRLVGLIAPEKDIDGANPLSLGRLAVGQPAFAPATAQAVVELLDHFQIPVAGRNVAVVGRSAVVGKPLSLLLLERDATVTICHSKSGPLERYTQPADVVVVAAGRTGLLKGSHLSPETVVIDVGTNVLPDGSLVGDVDEASVTGVAAGLSPVPGGVGSVTTALLLLHTVEAARQQSRSGLLTASTSRI
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 1.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL20_CALBD
Sequence: MRIKNGVWARKRHKKWLKLAKGYFGAKSKIFKQAHVAVMRSLRYAYIGRRLKKRDFRRLWITRINAAARQNGLSYSKFMNGLKKAGINLNRKVLADMAVNDQKAFAELVEIAKKQINAQ
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: Y1478_STRP3
Sequence: MTWKIVTDSGCDLRSLTRQSKELRFERVPLTLQIGTEIFRDDDGLDIDNMMTTMYQSSKATTSSCPSPEAFLQAYRGADNVIVMTITGTLSGSHNSARLAKNELLEENPNVNIHLIDSLSAGGEMDLLVLELERLINLGLSFEEVVKQITAYQQKTRLIFVLAKVDNLVKNGRLSKLVGKVIGLLNIRMVGKASNKGTLELLQKARGQKKAVSALIEEIQKEGYVGGKVYIAHAQNPKICEQISEKIKSLYPDAVIQTGRTSGLCSFYAEDGGLLMGYEI
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein SpyM3_1478.
Protein: YOBD_ECO55
Sequence: MTITDLVLILFIAALLAFAIYDQFIMPRRNGPTLLAIPLLRRGRIDSVIFVGLIVILIYNNVTNHGALITTWLLSALALMGFYIFWIRVPKIIFKQKGFFFANVWIEYSRIKAMNLSEDGVLVMQLEQRRLLIRVRNIDDLEKIYKLLVSTQ
What are the official names of this protein?
UPF0266 membrane protein YobD.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KRA57_HUMAN
Sequence: MGCCGCSEGCGSGCGGCGSGCGGCGSGCGGCGSSCCVPVCCCKPVCCCVPACSCSSCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQCSCYKPCCCSSGCGSSCCQSSCCKPCCCQSSCCKPCCCSSGCGSSCCQSSCCNPCCSQSSCCVPVCCQCKI
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 5-7, Keratin-associated protein 5-3, Keratin-associated protein 5.3, Keratin-associated protein 5.7, Ultrahigh sulfur keratin-associated protein 5.7.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 5 family.
Protein: COAD_CORGL
Sequence: MKAVCPGSFDPITLGHLDIVTRAAAQFSEVTILVTANPNKNSGLFTVAERMDLIRESTAHLDNVKVDTWASLLVDYTTEHGIGALVKGLRSSLDYEYELPMAQMNRRLTGVDTFFLLTDEKYGYVSSTLCKEVARFGGDVSGLLPEVVAKAVTEKYSNQH
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETXB_STAAU
Sequence: MYKRLFISHVILIFALILVISTPNVLAESQPDPKPDELHKSSKFTGLMENMKVLYDDNHVSAINVKSIDQFLYFDLIYSIKDTKLGNYDNVRVEFKNKDLADKYKDKYVDVFGANYYYQCYFSKKTNDINSHQTDKRKTCMYGGVTEHNGNQLDKYRSITVRVFEDGKNLLSFDVQTNKKKVTAQELDYLTRHYLVKNKKLYEFNNSPYETGYIKFIENENSFWYDMMPAPGDKFDQSKYLMMYNDNKMVDSKDVKIEVYLTTKKK
What is the function of this protein?
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules.  In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines (PubMed:2303780, PubMed:25015819).  Causes also the intoxication staphylococcal food poisoning syndrome (By similarity).
What are the official names of this protein?
Enterotoxin type B, SEB.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DTXR_CORGL
Sequence: MKDLVDTTEMYLRTIYELEEEGIVPLRARIAERLEQSGPTVSQTVARMERDGLVHVSPDRSLEMTPEGRSLAIAVMRKHRLAERLLTDIIGLDIHKVHDEACRWEHVMSDEVERRLVEVLDDVHRSPFGNPIPGLGEIGLDQADEPDSGVRAIDLPLGENLKARIVQLNEILQVDLEQFQALTDAGVEIGTEVDIINEQGRVVITHNGSSVELIDDLAHAVRVEKVEG
What is the function of this protein?
Iron-binding repressor of the dipheteria toxin gene expression.  May serve as a global regulator of gene expression (By similarity).  Represses ripA under iron excess.
What are the official names of this protein?
Diphtheria toxin repressor, Iron-dependent diphtheria tox regulatory element, Tox regulatory factor.
What is the protein family that this protein belongs to?
Belongs to the DtxR/MntR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_PROM2
Sequence: MLPSDLVKYKKNSQKIIALTAWDSISGSIAEQANVDLVLVGDSLAMVCLGYKSTLPLTLGNIIYHTNAVSRGFKKNIEEQPLVIADMPFLTYQCGEDKAVEYAGKIIQSTYAKAVKIEGAEPEIQKVISRLIRMGIPVMGHIGLTPQSYLNLGLKKQGESLESQEKIKKEASILEKLGCFSIVLEHIPDLLAKEIQNTLTIPTIGIGAGNYCDGQVRVTADLLGLNDDQPPFCQPIIQGKELFMKKLKEWVESERLN
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END8_SALAR
Sequence: MPEGPEIRRAADHLEAAIKGKLLTDVWFAFAQLKPYESQLTGQMVTRIETRGKALLTHFSNGLTLYSHNQLYGVWRVIDTGEIPHTTRILRVRLQTADKTILLYSASDIEMLTAEQLTTHPFLQRVGPDVLDARLTPEEVKARLLSPRFRNRQFSGLLLDQAFLAGLGNYLRVEILWQSELTGQHKAKDLSEAQLNTLSHALLDIPRLSYATRGQTDENKHHGAQFRFKVFHRDGEACERCGGIIEKTTLSSRPFYWCPHCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: XAC1_TRYB2
Sequence: MSKAPSQPAKKWMSARTLAKSEDATNRKSNTAAPASQPSQQPASVMHERPTPPPPAPVQLPQSVFFERQEAVDTLSNLYRNAQSVKKIETGPAAFEARDISKVHEELMDCLRPAAAA
What is the function of this protein?
Involved in post-transcriptional regulation of gene expression.
What are the official names of this protein?
PBP1-interacting protein XAC1, EXpression ACtivator 1.
What are the subcellular locations of this protein?
Cytoplasm.