Protein: TES_ALTAL
Sequence: MPGSLLFDVNKLDVEKIWERNRGPLRAVNRCVHSLYEEQAIARPNACAIHAWDGNMTYEQLNQHSTRLASYLVTQGIGTEVMVPLCFEKSIWAIVAMLAVLKAGAAFVPLDPMHPRARHEEIFKQTNAKLVLTSVQHAALWPNSGLQFLAIDKTFVDQLPWETKIRSKVKPIDAVYVMFTSGSTGVPKGVVLEHRAIATSCLAHGMEMKLGSDSRALQFAAYTFDICIAEIFTTLIFGGCVCVPSEDDRRNALSEVINNNNINWAQLTPTVARLLDPSTVPSLRVLVLGGERVDEADWKRWGDDIVKVNVYGPTECSIWCTSYSNTDREFRSGTIGTSMASFSWVTDPEDHNKLVPFGTIGELLIEGPILARGYLNDISKTEAVFVDGPLWLRQGNRNDESTRRQGRLYKTGDLVYYDADGNLVYAGRKDSQTKVRGQRIELGEIEHHLNQCMSGIKQVAAEVILPSGDQAKAMVAAFVQLSEEPRHALVQQTSNGDLEVRVIFPTYLDELLVQCLPKDMVPEVYFAVAELPLTTSAKVDRQKLRKIGASFSAQQLAQLRTYSDDPKRQPETEKEQILHHLWAQVLSIDASSIGMDDSFFDLGGDSIAAMKLVGEARRSGIYITVAVVFQNPTLDKLTSAAIPSVDVSNTTIPPVGHDGHVAQSFAQGRMWFLEELHPGLTWYLMPVVVRMRGPLELTALQSALNAIESRHETLRTTFETIGDTSMQLVHPYHAKELSIIDIDIKSLEEVLHRDQISPFDLRKEAGLRVSIYRIGSEEHVLSVIMHHIISDGWSTDVFTRELGAFYSASIRGHDPLVQVQPLPIQYRDFSVWQRQQAQIDKHRSQLNYWFNVLNTSRPAELLCDKARPAALSGEASKQTIQIDGPLYIQLLQFCKAKGVTKFMVLFAAFRATHFRLTGQNDATIGTVNANRDRWELKDMIGFFVNLQCLRTTIDADESFEELVQQVYEATIASLANADVPFENIVSKLKNSRDLSRHPLVQLVFAMHSQRNLGQLKLEGLETESLDNAPKSRFDLEFHFFQQEDSLKGEVVYSTDIYSPEAIDNMLSIFQIVLEGCLQEPKAAIASLSLLCDVELSKLNSMGLIQVEKTDYPRESSVVDLFRQQTSLCPSRIAVKDASVTMTYTQLDKESDILAQWLAKQSLAPETLVSVLAGRSCQTIVAFLAILKAGLAYLPFDVRVPAKRMSTILGSLSGPKFVLLGEDVQPPYVDISDIRFIRITEALDEQTHEGSASRDIVKPTANSLAYVMFTSGSTGQPKGAMIEHRGIVRLVRDNNFVQHLPASPVMAHMTNLAFDVSTWEIYASLLQGGTLVCIDRLTVLDPEAVLRTFRQEHVSTAFMTPSLFRTYVQQLPALFAGLDMLCVGGEALHSNDILSMTTLRTGKIINGYGPTENTTFNTTFVLSREGQYPNGVPIGRALSNSGAYVMDLKQQLVPLGVVGELVVTGDGLARGYTDLERNIYRFITVQIGGEVVKAYRTGDSVRYRPADGQLEYFGRMDGQVKIRGHRIELGEIEHVLRSHGSVREAVAVVQQQQNADEAARLAAFVTVYEGDELVEEKPSGIDESEHVDVWEDQFDSKVYTPISKVLPEAIGRDFIGWTSMYDGSAIDKVEMNEWLDDTIDTMLNGHPPGKVLEVGTGTGMVLFNLGDGLESYVGLDPSSRAVEFVKDTVRSVPTLADKVRVYKATATEIDRLEPIDASLIVINSVIQYFPSLEYLFKTTQQLLGLESVSTIFFGDVRSYALHREFLATRAMFMAGDSADRAEVSRMITDMELVEKELLVDPAFFTALPERLPDQVEHVEILPKKMKATNELSCYRYAAVIHVKPRDGRKQEQRIRHVGHDEWIDFREHKLDRQSLLAQLQSNPRPSTMAVSNIPYSKTIVSRCLIESIDNAVAELSDPQDWYSSVCQRAQCSSSMSATDLYELAKEANCRVEVSWSRQHSQCGGIDAIFHRYPPRGGENRVMFQFPTDHAERPLHTLSSMPLRQQTLQRIQGQLQEMLDAQLPAYMVPQTVTFLETMPTNQNGKIDRNALTQRTEIQVAKGQEFQRELTRAESKIQQLIARVLRIDSDRIGLDDSFFQLGGDSIAAMKLVALARDEDIRLTVAKIFQYPKLIQLAAVAQEHVYVPNDNIVPFSLLDDEVDATQTHHEVAVKCAIDRGIIEDIYPCSPLQEGLMSLTVKRPGDYIMQTVLELREEVDETAFKIAWEKTVQSFQILRTRIVIHETLGLLQAVIAEKIKWADADDLATYLARDKLSSMQLGKPLARYGLVRDTRREKKWFVWTIHHAIYDGWALNHISVLCKQHTMAGKPGKQVGFNSFIKYLRQMDEDALAEYRRTTLSDCDANVFPPLVSGVQQPVADATAEYCCPPLPKRTSNTTISTLVRAAWAIVASGYTSSDDVVFGATVTGRNAPVAGIESLVGPVIATVPVRIRLQRDSTILEFLETVQKQATEMIPFEQTGLQRIAKLGPDTEHACNFQTLLIVQPAEDAFQSDDMFGTWEFGSGLQDFTTYGLMVQCKLAKEGVKITASFDARLVEQWQVERMLGQLSFVMQQLARGDSRTRVMDIGMLTQDDEQQLWMWNQRLPPAIDRCVHDLYSDQAKSRPEADAICAWDGVMTYKELDERSSRLATYLVDIGVKPETIVPLCFEKSMWMVVAMLAVLKAGGAFAPLDPSHPVSRHRDIFTQTKANMMLTSSQYANLWSEYIPTVVEITGHFIDQLTTNPYSTETAVQPGNTAYVIFTSGSTGVPKGVQMEHKAVSTSCSCQGPALGITEDTRVLQFAAYTFDACILEIITTLLHGACICIPSETQRRDHLVNTINTMKVTWALLTPAVARILDPQKIVSLKTLVLGGEKVNGSDCDTWSGRVRLINAYGPTECCVSCVASPDMKGLDPEPIGKPIASIGWVTNPNDHNRLAPLGAVGELLVEGPNLARGYLDDAKKTETAFVHDPLWLLRGCEGYSGRRGRLYKTGDLVYHTSDGDLVYVGRKDGQVKVRGQRIELAEIEICLYQHISDIKEIAVELISPTGGKPMIAAFLKANPELLNDKLSDGDSGVYVVYPARVDNELSQRLPRNMVPEVYFALTEFPISTSGKINRRRLREIGGSFSTDQLARLRTQKNESSDRKPETKHEMALQKLWAQVLNIEATSIGLNDSFFQLGGDSISAMKLVSEARNVDLVFSVQDVFQVQRLGRLANRLVDPPTSSHSAITKIDHQRPVLQSFAQGRLWFLEQLHPGLDWYLMHLAVRIKGPVQLPALQAALQAIEHRHETLRTTFSTNNGESLQEVHPFCGGRELNVIDVGSNDDKILLEALERDQKTPFNLRYEPGWRISIYRINDVSHVLSIVMHHIVSDGWSVDVLKKELSALYASAIRNEDPIFCLPPLPIQYRDFSVWQRLPEQAQEHRRQLDYWINQLDGSRPAEFLYDKPRPTTLSGKAGTQRLNISHKLYNRLQIFARQRGMTPFVVLLAVFRATHYRLTNQDDATIAVPNANRSRPELGDLIGFFVNIQCMRMKIQDETFEELLQHAYKTVVDSLANQDVPFESIVSALQGDRDSSRNPLAQVAFAVHSQQDIGKLDFEGVGTEAIEGLATSRFDLEFHFFQEKNGFQGYIYFSEELFVPETIYSLASVFTSILDNCLDKPETQIAVVPLMTVEAHTQLDQMGLLRMHQTAYPRNSSIVDVFRQQAAMQPSRVAVKDTSTDLTYAQLDSQSEKLAKFLATKSFAPETAVGVLAHRCCQAIVAFIGILKAGLAYLPFDHKAPEKRMESIFSTIEGNKLVLIGPNISLPGTGPKDVEFAYIPDILDADEDFEFTRSELDPTLRPTASSLAYILFTSGSTGQPKGVMVEHRGIVRLAQHDQMEHFKSSGAMAHMANLAFDGSSWEIYTCLLNGGTLVCIDATTVLDQDALLRAFTESQIRIAFITPALLNYILAESPDTIGNLDTLLVAGDRADVDDVFRARDLVRNKVVANAYGPTENSVMSTLYILSEDENCVNGVPIGRPISNSAAYVMDPEQNLVPLGVFGELVVTGDGVARGYTDPRRNVDRFVTVTIGHQTMRAYRTGDYVRQRPRDGEMEFFGRIDGQVKIRGNRVELGEIETVLRGHGLVRDAVVVAEQRKDKNQRLFGYITLKEDFEMLSAQNSDDDQIQHVNAWEHRFNTETYAQIVGIQSETVGQDFIGWTSMYDGTDIDKTEMKEWLEETIGSIHDKVGGQLGNVLEIGSGSGMILFNLGDSLKHYTGFEPSRKAVEFVTGTARSIPSLANKVEMYKATAADISKVDQPLQADLVVLNSVVQYFPSQGYLFNVVRDLLKVDGVKTLFFGDIRSYALRREFYAARALFMAGERASQKDLRRLVEDMEQIEQELLVDPGFFTSLTHRLPDLVQHVEIQPKRMRATNELSSYRYTAVVYSRSREPPCGGLRTIPDNEWIDFQEQGLNNDSLQQRIKDVSSTHPLAVSNISHTKTLFGNCLLGALGDGKARKPVHTDWTAHINRQAKGIPSLSAVDLDEMAKAAGCQVRISWNRQYSQHGGLDAIFYPRQINGGSDKAGVMFSFPTDHAERRRQTLSNKPMRQQLVKEVQQQLDELVKVQLPSYMVPQSIQVLNQLPINQNGKVDRKALIQRTRTQTEVSQGGLQRELSTAELKVQRILSRVLGIEASRMGLEDSFFQLGGDSIAAMKIVAAAREEEIHLTIANIFQHPKLVNLATVAQFSQHEGEQKSIQPFSLLSTTQRDYLLHAIPENTSNVNGNDIIDILPTTWMQNLFISRGVNIQPLAFNYFFLNLGTRVDASRLRSSIPTLVQQFSILRTKFVYVDGVLWQTVLRKPHVPFTEFHLDMSLEEAADTVCLEDSRTTDPLELATAFMLIRGTSNEHLLAIRITHAQYDGVCFPSFVKALFAIYSGKSVEPAHNHSTYLAYTRERKSVSALHWRDVLHGSRMTKATPLLSPSIRHGMIPVEVQTESIIGMPHVPTGLTLASLVSAAWAKVLSQITGEEDVVYGYMVAGRNANIPAITKIVGPCLNIIPVRARLHAKTTSTELIRSIQEQYIALGEADSMGFDEIVRTSTDWPADTEYDSVFQHQNLNEHPEFDFEGTSSRLHWFQNPDSVPCILTVVSYPLEDGLRIVVRGNEHIITPESAERINKLLCETIGALSSSLQ
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the phytotoxin tentoxin, an inhibitor the F1-ATPase activity of chloroplasts, resulting in chlorosis in sensitive plants (PubMed:27490569, PubMed:7881545).  Tentoxin is a cyclic tetrapeptide that consists of four amino acid residues: glycine (Gly), alanine (Ala), leucine (Leu), and dehydrophenylalanine (DPhe) (PubMed:27490569, PubMed:7881545).  In addition, both the Ala and DPhe residues are N-methylated (PubMed:27490569, PubMed:7881545).  The nonribosomal peptide synthetase TES assembles tentoxin from the four substrate amino acids (PubMed:27490569).  The adenylation domains of each of the 4 modules are responsible for the activation of Gly, Ala, Leu and DPhe, respectively (PubMed:27490569).  In addition, the N-methyltransferase domains in the second and fourth modules of TES could be responsible for N-methylation of Ala and DPhe residues (PubMed:27490569).  Finally, the condensation domain located in the termination module probably catalyzes the formation of the intramolecular macrocyclization and then the release of tentoxin (PubMed:27490569).  The cytochrome P450 monooxygenase TES1 is predicted to be involved in the formation of DPhe (PubMed:27490569).
What are the official names of this protein?
Nonribosomal peptide synthetase TES, Tentoxin synthase, TES.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.