PharMolix/UniProtQA huggingface dataset:
Protein: UVRB_BORPA
Sequence: MTAPGFVEFPDSPFHLYQPYPPAGDQPGAIDALTEGVSDGLMFQTLLGVTGSGKTYTMANMIARLGRPALVLAPNKTLAAQLYAEMREFFPRNAVEYFVSYYDYYQPEAYVPTRDLFIEKDSSINEHIEQMRLSATKSLLERRDTVIVGTVSCIYGIGNPGDYHAMVLILRTGDRISRREVLARLVAMQYTRNDADFTRGVFRVRGETIDIFPAESPELALRLTLFDDEIESLELFDPLTGRVRQKLPRFTVYPGSHYVTPRETVLRAIETIKEELRERLAQLIADGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHLSGAAPGEPPPTLIDYLPADALMFIDESHVTIGQLGGMYRGDRSRKETLVQYGFRLPSALDNRPLRLEEFEARMRQCVFVSATPAAYEQEHADNVVEQVVRPTGLVDPIVEVRPAHTQVDDLLGEIHKRAALQERVLVTTLTKRMAEDLTDFLSEHGVRVRYLHSDIDTVERVEIIRDLRLGVFDVLVGISLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGRAILYADRITDSMRRAIDETERRRAKQIQHNTDHGITARGVSKAVRELIDGVVAPAGHDALESAVPAEVLTDEKAMAREIRRLEKLMMDHARNLEFEQAAAARDALNALKSRLLLDGVG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLU7_SCHPO
Sequence: MSYMNNTFQSNYDYSKDKNFMSTDIGPSMREMKAQKRRSRPMDNPDADNPYIPKFISTAPWYAQDDDAVERLAHQRIGKKETPSGGRSSIEGSWYVRGKKLGPAATKYRKGACENCGAMSHKVKDCMERPRKRGARWTGEDIQADEVIQDINVSWDAKRDRWNGYDATDYKKVIERYEKLDELQNKGEENRDASENSAVKASRNSTVSGSEDSASITTPSLRMREDVVAYLRADNKNLQYEPKSRSMRDETGYHMVDDSSGGAGFVKASGGEKEDFEKLQMFAWEAERSGTRVHVVANPTAGELEFRKNKASRMTTQKHIDQSILDRYGDGTSKVKDKKAKNNEKEVPDLAILDKSEKSKGESNTDEESENLVIVEGDL
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor slu7.
What is the protein family that this protein belongs to?
Belongs to the SLU7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PG107_VAR67
Sequence: MDKTTLSVNACNLEYVREKAIVGVQAAKTSTLIFFVIILAISALLLWFQTSDNPVFNELTRYMRIKNTVNDWKSLTDSKTKLESDRGRLLAAGKDDIFEFKCVDFGAYFIAMRLDKKTYLPQAIRRGTGDAWMVKKAAKVDPSAQQFCQYLIKHKSNNVITCGNEMLNELGYSGYFMSPHWCSDLSNME
What is the function of this protein?
Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry.  Also plays a role in cell-cell fusion (syncytium formation).
What are the official names of this protein?
Late protein H2.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG107 family.
Protein: THAD_ARATH
Sequence: MASMITVDFENCFIFLLLCLFSRLSYDLFFRKTKDSRAGCALPPSPPSLPIIGHLHLILFVPIHQSFKNISSKYGPLLHLRFFNFPIVLVSSASTAYEIFKAQDVNVSSRPPPPIEESLILGSSSFINTPYGDYSKFMKKFMVQKLLGPQALQRSRNIRADELERFYKTLLDKAMKKQTVEIRNEAMKLTNNTICKMIMGRSCSEENGEAETVRGLVTESIFLTKKHFLGAMFHKPLKKLGISLFAKELMNVSNRFDELLEKILVEHEEKLQEHHQTSDMLDMLLEAYGDENAEYKITRDQIKSLFVDLFSAGTEASANTIQWTMAEIIKNPKICERLREEIDSVVGKTRLVQETDLPNLPYLQAIVKEGLRLHPPGPVVRTFKETCEIKGFYIPEKTRLFVNVYAIMRDPDFWEDPEEFKPERFLASSRLGEEDEKREDMLKYIPFGSGRRACPGSHLAYTVVGSVIGMMVQHFDWIIKGEKINMKEGGTMTLTMAHPLKCTPVPRNLNT
What is the function of this protein?
Converts thalian-diol to a desaturated thalian-diol.
What are the official names of this protein?
Cytochrome P450 705A5, Thalian-diol desaturase, AtTHAD.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: WRK32_ARATH
Sequence: MEEDTGIDEAKTYTVEKSEKVEPEKDGLSQFRDEEKSLGADMEDLHDETVRETLGKDQVQGVRENSSVEPNVEDVLEVNETDSVKETVVSAIVPVDEVEENRQVETSPSLAASSDSLTVTPCLSLDPATASTAQDLPLVSVPTKQEQRSDSPVVNRLSVTPVPRTPARDGYNWRKYGQKQVKSPKGSRSYYRCTYTECCAKKIECSNDSGNVVEIVNKGLHTHEPPRKTSFSPREIRVTTAIRPVSEDDTVVEELSIVPSGSDPSASTKEYICESQTLVDRKRHCENEAVEEPEPKRRLKKDNSQSSDSVSKPGKKNKFVVHAAGDVGICGDGYRWRKYGQKMVKGNPHPRNYYRCTSAGCPVRKHIETAVENTKAVIITYKGVHNHDMPVPKKRHGPPSSMLVAAAAPTSMRTRTDDQVNIPTSSQCSVGRESEKQSKEALDVGGEKVMESARTLLSIGFEIKQC
What is the function of this protein?
Transcription factor.  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
What are the official names of this protein?
Probable WRKY transcription factor 32, WRKY DNA-binding protein 32.
What is the protein family that this protein belongs to?
Belongs to the WRKY group I family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLN14_ARATH
Sequence: MSSLADLINLDLSDSTDQIIAEYIWIGGSGLDMRSKARTLPGPVTDPSQLPKWNYDGSSTGQAPGDDSEVIIYPQAIFKDPFRRGNNILVMCDAYTPAGEPIPTNKRHAAAKIFEDPSVVAEETWYGIEQEYTLLQKDIKWPVGWPVGGFPGPQGPYYCGVGADKAFGRDIVDSHYKACLYAGINVSGTNGEVMPGQWEFQVGPTVGIAAADQVWVARYILERITELAGVVLSLDPKPIPGDWNGAGAHTNYSTKSMREDGGYEVIKKAIEKLGLRHKEHIAAYGEGNERRLTGKHETADINTFLWGVANRGASIRVGRDTEQAGKGYFEDRRPASNMDPYTVTSMIAESTILWKP
What is the function of this protein?
High-affinity glutamine synthetase (PubMed:14757761, PubMed:16338958).  May contribute to the homeostatic control of glutamine synthesis in roots (PubMed:14757761).
What are the official names of this protein?
Glutamine synthetase cytosolic isozyme 1-4, Glutamate--ammonia ligase GLN1;4, GLN1;4.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_CLOK5
Sequence: MNKVEIAGLGSYVPPKILDNNDLSLIVDTNDEWIRCRTGIRQRRISQGENTSEMATKAAINAMKSANIKAEDIDLIVVATITPDNFIPSTACIVQKNIKAVNATCFDISAACSGLIYGLDIGTQFIRSGRFKVVLAIGAETLSKILNWQDRSTCILFGDGAAAAILQMGEEESILSMYTGSDGFQGDALTCPAVPVNNPCTTSDFQKSVVTMDGKAIFKFAVKILVKSVKMLLKEQEVTLEEIKYIIPHQANYRIIECAAKILKVDIDKFYINLDLYGNTSAASVGIALDEVYKKNLVEKGDKVLIIGFGGGLTYGGLLINVI
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UGTP_STAA8
Sequence: MVTQNKKILIITGSFGNGHMQVTQSIVNQLNDMNLDHLSVIEHDLFMEAHPILTSICKKWYINSFKYFRNMYKGFYYSRPDKLDKCFYKYYGLNKLINLLIKEKPDLILLTFPTPVMSVLTEQFNINIPVATVMTDYRLHKNWITPYSTRYYVATKETKQDFIDVGIDPSTVKVTGIPIDNKFETPINQKQWLIDNNLDPDKQTILMSAGAFGVSKGFDTMITDILAKSANAQVVMICGKSKELKRSLTAKFKSNENVLILGYTKHMNEWMASSQLMITKPGGITITEGFARCIPMIFLNPAPGQELENALYFEEKGFGKIADTPEEAIKIVASLTNGNEQLTNMISTMEQDKIKYATQTICRDLLDLIGHSSQPQEIYGKVPLYARFFVK
What is the function of this protein?
Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids.  Is able to successively transfer two glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol).  Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).  UgtP can only use UDP-glucose as sugar donor.
What are the official names of this protein?
Processive diacylglycerol beta-glucosyltransferase, Beta-diglucosyldiacylglycerol synthase, Beta-DGS, DGlcDAG synthase, Glc2-DAG synthase, Beta-gentiobiosyldiacylglycerol synthase, Beta-monoglucosyldiacylglycerol synthase, Beta-MGS, MGlcDAG synthase, Diglucosyl diacylglycerol synthase (1,6-linking), Glucosyl-beta-1,6-glucosyldiacylglycerol synthase, UDP glucosyltransferase, UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. UgtP subfamily.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RBFA_MYCGI
Sequence: MPDPARAKRLAKRISTIVASAIEYEIKDPRLAGVTITDAKVTNDLHDATLYYTVLGRSLDEEPDYEGAAAGLEKAKGVLRTKVGASLGVRFTPTLAFARDTVPDAAHRMEALLAQARAADEDLARVREGAKHAGDSDPYRVLGEGDLEGPATGGPDVEDEGGANSHDR
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAP6_YEAST
Sequence: MQNPPLIRPDMYNQGSSSMATYNASEKNLNEHPSPQIAQPSTSQKLPYRINPTTTNGDTDISVNSNPIQPPLPNLMHLSGPSDYRSMHQSPIHPSYIIPPHSNERKQSASYNRPQNAHVSIQPSVVFPPKSYSISYAPYQINPPLPNGLPNQSISLNKEYIAEEQLSTLPSRNTSVTTAPPSFQNSADTAKNSADNNDNNDNVTKPVPDKDTQLISSSGKTLRNTRRAAQNRTAQKAFRQRKEKYIKNLEQKSKIFDDLLAENNNFKSLNDSLRNDNNILIAQHEAIRNAITMLRSEYDVLCNENNMLKNENSIIKNEHNMSRNENENLKLENKRFHAEYIRMIEDIENTKRKEQEQRDEIEQLKKKIRSLEEIVGRHSDSAT
What is the function of this protein?
Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements.  According to genome-wide promoter binding and gene expression studies it regulates, among others, genes involved in ribosome biogenesis, protein synthesis, carbohydrate metabolism, and carbohydrate transport.  It may also be involved in pleiotropic drug resistance.  When overexpressed, it confers resistance to cisplatin, methylmethanosulfonate, and mitomycin C, and increases cellular tolerance to sodium and lithium.
What are the official names of this protein?
AP-1-like transcription factor YAP6.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. YAP subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CTU1_VANPO
Sequence: MFTAPSDPVNVRKELKVTQLCELCHSRKAIIRRPKNLQKICKLCFFHVFETEIHETIVSNDLFYRGERVAVGASGGKDSTVLAYVLKLLNERHDYGIEIVLLSIDEGIVGYRDDSLATVKRNQQQYQLPLEIFSYQDLYDWTMDDIVETAGIRNSCTYCGVLRRQALDRGAAKLEIKHVVTGHNADDMAETVLMNILRGDVARLEKSTSIMTSSTGSPIKRSKPFKYCYQKEIVLYAHYKKLDYFSTECTYAPEAFRGTARELMKNFEAIRPSCIIDIIASGESFVLKQKMGKQNKKKIITYNDGNRCERCGYLSSNKICKACMLLEGLEKSRAQIKIQVQVPGEPQQEGPAKVLRTLERLTF
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1163_VIBCM
Sequence: MAELISIDDTIDTAYDIFLEMAPDNLEPADVILFTAQFDDRGAAELVDVGDDWDDQVGFEVDKEIYAEVRIGLVNEENDVLDDVFARMLISRDPDQKFCHMLWKRD
What are the official names of this protein?
UPF0263 protein VCM66_1163.
What is the protein family that this protein belongs to?
Belongs to the UPF0263 family.
Protein: Y1856_STRPD
Sequence: MLTFLIPTAKEMMIPKESHPHLLPQDSQAILKIMAAMTTEDLAKSYRIKEEAAKKEQQRWQDMASQQSLAYPAYQLFNGLMYRHIKRDKLTTQEQAYLTQQVYITSSFYGIIPANHPIAEHRHDFHTRIKIEGQSLKSYWRPCYNQFAKEHPQVISLLSSEFDDVFSKDCKQLWISPKFMAEKEGQFKTHSTISKKARGAFLTACMENNCQTVDSLKSLVFAGFYYHPDLSTDHEFVYIKKEA
What are the official names of this protein?
UPF0246 protein MGAS10270_Spy1856.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: DBP5_PICST
Sequence: MSAEKRVEADAAELLSSLSLGESPAEKKDEKTEEVKKEEAKSEELNKVVEKTEEKVKEANAEDAKPEELKEVGKEENEEPKTNLIQSTYEVKVKLADIQADPNSPLFSVKSFEELGLTPELLKGLYAMKFNKPSKIQEKALPLLISNPPRNMIGQSQSGTGKTAAFSLTMLSRVDPKVPSTQCLCLAPTRELARQTLEVISTMGKFTNITTQLIVPDALPRGSSTNAHIIVGTPGIVMDLIRRKQINVNGVKVFVLDEADNMLDAQGLGDQCVRVKRTLPKTTQLVLFSATFPTKVRQYAEKFVPNANSLELKQEELNVDGIKQLYMDCDSEKHKFEVLCELYGLLTIGSSIIFVERKDTANLLYAKMKAEGHACSILHGGLETSERDRLIDDFREGRSKVLITTNVLARGIDIASVSMVVNYDLPTDKDGNADPSTYLHRIGRTGRFGRVGVSISFIYDKRSYEILMKIKDYFGNVEMTRVPTDDWDEVEKIVKKVIKS
What is the function of this protein?
ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus.  May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex.  May also be involved in early transcription (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.
Protein: WHIA_BACAN
Sequence: MSFASETKKELTNLEMKECCEKAELSALLRMNGSLSFSNRRLSIDIQTENAAIARRIYTLLKKGYDVTVELLVRKKMRLKKNNVYIVRLVEKSREILADLHIVRDDFSFIRNISQELIEKKCCKRSYLRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDAICELMNGFDLNSKTLERRKGYITYLKEAEKITEFLNIIGAHNALLRFEDIRIVRDMRNSVNRLVNCETANLNKTIGAALRQIENIRYIDETVGLDILPDKLREIAQLRRDYQDVTLKELGEMVSGGKISKSGINHRLRKIDDIAEKLRAGETVAKK
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: Y2091_STRA5
Sequence: MGFTDETVRFRLDDSNKVEISETLTAVYRSLEEKGYNPINQIVGYVLSGDPAYVPRYNDARNQIRKYERDEIVEELVRYYLQGNGIDL
What are the official names of this protein?
UPF0297 protein SAG2091.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: RS12_BRUO2
Sequence: MPTVNQLIRKPRTAPVKRNKVPALQANPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: DJC10_MOUSE
Sequence: MGVWLNKDDFIRDLKRISLCLLILYVVVVVGTDQNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWSYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYNGDRSKESLVAFAMQHVRSTVTELSTGNFVNAIETAFAAGVGWLITFCSKGEDCLTSQTRLRLSGMLDGLVNVGWVDCDAQDSLCKSLDTTASTTAYFPPGATLNDREKSSVLFLNSLDAKEIYMEIIHNLPDFELLSANQLEDRLAHHRWLVFFHFGKNENANDPELKKLKTLLKNEHIQVGRFDCSSAPGICSDLYVFQPCLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPASDKEPWLVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVFNQSSIHEYEGHHSAEQILEFIEDLRNPSVVSLTPSTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQKSSKAYQYHSYNGWNRDAYSLRSWGLGFLPQASIDLTPQTFNEKVLQGKTHWVVDFYAPWCGPCQNFAPEFELLARMIKGKVRAGKVDCQAYPQTCQKAGIKAYPSVKLYQYERAKKSIWEEQINSRDAKTIAALIYGKLETLQSQVKRNKDEL
What is the function of this protein?
Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.  Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR.  Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1.  Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate.  Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
What are the official names of this protein?
DnaJ homolog subfamily C member 10, Endoplasmic reticulum DNA J domain-containing protein 5, ER-resident protein ERdj5, ERdj5, Endoplasmic reticulum DnaJ-PDI fusion protein 1, J domain-containing protein disulfide isomerase-like protein, J domain-containing PDI-like protein, JPDI.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: YCAR_ECODH
Sequence: MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS
What are the official names of this protein?
UPF0434 protein YcaR.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: TBA8_MOUSE
Sequence: MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-8 chain, Alpha-tubulin 8.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: NUOD_METI4
Sequence: MAEGLTREVRMEVPDTAELLRRSEDISGAPEGERLILNMGPSHPSTHGVFQLLLELDGEVITKAIPEVGYLHRGDEKIAENMQYNQFVPYTDRLDYLAPLANNVVYACAVEKLLGWEIPARAQVIRVICSEMARISSHLMGLGAYAMDCGAVSVFLYTFTEREKIYLLIEELTGARFTTSYTRIGGLTRDLPPGWTEKLKDFIKQFLPKVDEIEGLLTKNKIFVDRTQDIGIISKEDAIDYGLTGPNLRGSGVDHDLRKKNPYLGYEKYDFEVPLGSVGDCFDRYMVRIEEMRQSCRILDQALADIPPGPIAVDEPRGYLPKKSAVLTKMEELIQHFIVVTQGVDVPPGEVYFGGENPKGELGFYIVSKGGGVPYRLKIRSPSFVNLSILPKILPGHLLSDVVAILGSLDFVMGECDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MIOC_PASMU
Sequence: MKTKICIITGSTLGGAEYVAEHIAEILEQQDYPVRLEHGPNFEEVIDEKCWLVVTSTHGAGELPDNIKPLFEKLAFHPKQLADLRFAVIGLGNSDYDTFCHAVDHVEQLLLSKDALQLCESLRMDMLTITDPEHTAEQWLPQFLSQL
What is the function of this protein?
Probable electron transporter required for biotin synthase activity.
What are the official names of this protein?
Protein MioC homolog.
What is the protein family that this protein belongs to?
Belongs to the flavodoxin family. MioC subfamily.
Protein: RBSD_STRU0
Sequence: MKKHGILNSDLAKIVDDLGHTDRVCIGDLGLPIPSGVRKIDLSLKAGFPSFQDLLDVYLEHVLVEKIILAEEIKEQNPEQLSQILRKLDDGVTVEYVSHEQLKALNQDVKAVIRTGENTPYSNIILQSGVTI
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPA_PELTS
Sequence: MISDFGRLVTAMVTPFNKDLSVNYNLTRKLARYLVQSGSDGLVVAGTTGESPTLSREEKVELFRVVVDEVGGRATVIAGTGSNSTSESISLTQAAQKVGVDAVMLVVPYYNKPSQEGLYRHFKAVAESTDLPIMLYNVPGRTSVNILPQTVARLAEIDNIVAIKEAGGNMDQISEMRRLLPDGFNVYSGDDSLTLPVLSLGGKGVVSVVSHLVGGRIQEMINAYTSGNTTLATEIHLELFPLFKGMFITTNPVPVKTALSLMGWEVGATRPPLAEASPAEKESIKNLLESMKLI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_PORGI
Sequence: MAEKRDYYEVLGVSKNATDDELKKAYRKKAIQYHPDKNPGDKEAEEHFKEVAEAYDVLSDPQKRSQYDQFGHAGLGGAAGGGFSGGGMSMEDIFSRFGDLFGGFGGFGGFSDMGGGSRRRVRRGSDLRVRVKLSLADISKGVEKKVKVKKQVVCSKCRGDGTEEANGKTTCQTCHGTGVVTRVSNTFLGAMQTQSTCPTCHGEGEIITKPCSKCKGEGVEIGEEVISFHIPAGVAEGMQMSVNGKGNAAPRGGVNGDLIVVIAEEPDPNLIRNGNDLIYNLLISVPLAIKGGSVEVPTIDGRAKIRIEAGTQPGKMLRLRNKGLPSVNGYGMGDQLVNVNVYIPESIDAKDEQAIAAMENSDSFKPTDAARKDIDKKYREMLD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.