PharMolix/UniProtQA huggingface dataset:
Protein: PURQ_THET8
Sequence: MRWAIVRFPGANCDEDARFALEKAGIRAEFVWHTERDLRGFDGVFLPGGFSYGDYLRAGALAAKSPVMEAVRRFAEEGRYVVGVCNGFQILTEAGLLPGALLANLNLHFTCKEVGVRVERNDLPFTRLYPRGQVLRLPIAHGEGRYYADPETLARLEGEGLVVFRYAPLKDEADYNPNGSLHDIAGIVSEKGNVLGMMPHPERAVDEVLGNTDGLPFFLGLVKEVAR
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_ECOUT
Sequence: MKPNIHPEYRTVVFHDTSVDEYFKIGSTIKTDREIELDGVTYPYVTIDVSSKSHPFYTGKLRTVASEGNVARFTQRFGRFVSTKKGA
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: PAQR4_MOUSE
Sequence: MAFLTGPRLLDWASSPPHLQFNKFVLTGYRPASSGSGCLRSLFYLHNELGNIYTHGLALLGFLVLVPMTMPWSQLGKDGWLGGTHCVACLVPPAASVLYHLFMCHQGGSPVYTRLLALDMCGVCLVNTLGALPIIHCTLACRPWLRPAALMGYTALSGVAGWRALTAPSTSARLRAFGWQAGARLLVFGARGVGLGSGAPGSLPCYLRMDALALLGGLVNVARLPERWGPGRFDYWGNSHQIMHLLSVGSILQLHAGVVPDLLWAAHHACPPD
What are the official names of this protein?
Progestin and adipoQ receptor family member 4, Progestin and adipoQ receptor family member IV.
What is the protein family that this protein belongs to?
Belongs to the ADIPOR family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KYNB_BURTA
Sequence: MDTIWDISPPIAPATPVWPGDTPVGIERVWRIEAGSPVNVARITLSPHTGAHADAPLHYDAHGAPIGAVPLDAYLGRCRVIHCIGAHPVVSPDDVRAALADAPPRVLLRTYGQAPQRAWDSAFCAVAPQTIDLLAAHGVRLVGIDTPSLDPQESKTMDAHRRIRAHGMAILEGLVLDEIAAGDYELIALPLKFATLDASPVRAVLRALPDAPR
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: INT11_BOVIN
Sequence: MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFSDDRRFPDFSYNTRSGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTQPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPSLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMDLKAPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADSPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPENVLLVHGEAKKMEFLKQKIEQEFRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPDAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQEMAMRVYSHLKSVLKDHCVQHLPDGSVTVESILVQAAAHSEDPGTKVLLVSWTYQDEELGSYLTSLLKKGLPQAS
What is the function of this protein?
Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.  The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.  Mediates the snRNAs 3' cleavage.  Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
What are the official names of this protein?
Integrator complex subunit 11, Int11, Cleavage and polyadenylation-specific factor 3-like protein, CPSF3-like protein.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CYT5_ORYSJ
Sequence: MASKLYYAVAPLVLVLLLLAPLSSARLAAAAAADDDGQWPAGGGRGRKVGGRTDVEDVEGNREVQELGLFCVVEHNRRGGSATRGRGLVFSRVVAAQTQVVSGIKYYLRIAAQEADDELVFDAVVVVKAWVPSREMVSFVPAAELPGY
What is the function of this protein?
Specific inhibitor of cysteine proteinases.  Probably involved in the regulation of endogenous processes and in defense against pests and pathogens (By similarity).
What are the official names of this protein?
Cysteine proteinase inhibitor 5, Oryzacystatin V, OC-V, Oryzacystatin-5.
What is the protein family that this protein belongs to?
Belongs to the cystatin family. Phytocystatin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2501_BURCH
Sequence: MLSPCPILPSAECRDTADTPADPPGRVIPINRRRRRPGDWRPERPRERLLERGPAALTDDELIALLLGTGKPGHDVFVTARALVDQFGTLHGLLEATADDFEAHPGIGPARSARLVAVTEIARRMLVEKAEERMQIDSPGAVEDCLRLKIGTRQYEVFIAVYLDARNRLIDMEEIARGSLTRMAVYPREIVRRAMKHNAAALIVAHNHPSGAVQPSAEDRRLTRVLKDALELVDVRLLDHVVVGVSDTFSFARAGWL
What are the official names of this protein?
UPF0758 protein Bcen2424_2501.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: SURE_YERPB
Sequence: MIRILLSNDDGISAPGIQTLASALREFAQVQIVAPDRNRSGASNALTLDSALRITTLSNGDIAVQQGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGYPALAVSLNGHQHYDTAAAVTCRLLRALQRKPLRTGKILNINVPDLPLSEIKGIRVTRCGSRHPAEQVFCQQDPRGQDLYWIGPPGEKYDAGPDTDFAAVEQGYVSITPLQVDLTAYTAQEVVESWLANTEVDGEW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLIP_ESOLU
Sequence: MATTISTQRGQVYIGELPQDFLRITPTQQQQQVQLDAQAAQQLQYGGSLGTVGRLSITVVQAKLAKNYGMTRMDPYCRVRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVGSFYLEIFDERAFSMDDRIAWTHVTIPEGLREGSVVDEWYSLSDRQGDDKEGMINLVMSFANMPAGMHMSPPVVLMPTVYQQGVGYIPIAGVPTAYSPGMVPMGMPAAPTVTPQEAPCSEEDLKALQDMFPNLDREVIRTVIEAQQGNKDAAINSLLQMTEEL
What is the function of this protein?
Component of the signaling pathway of IL-1 and Toll-like receptors.  Inhibits cell activation by microbial products.  Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates.  The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).  In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity).  Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity).
What are the official names of this protein?
Toll-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the tollip family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INKA1_MOUSE
Sequence: MHSARLDSFLSQLRWELLCARDTGSPPMSGPLQPKPRTDQNVQPKRQFRASDVLEEDSVCCVEEEEEEGLVAEDKGLPLGCPREHALDWDSGFSEVSGSTWREEEPSVPQRQAPRERPPHSQRFSVSDIPMRSRAAVTNIPPAHRPRPKSTPDACLEHWQGLEAEDWTAALLNRGRSRQPLVLGDNCFADLVHNWMELPEATSEGSDGDVPRARARPPQFLLGLSEQLRRRLARARRTAMASKRLSCPPRSEPDLPADISRFAALMNCRSRQPIIYNDVSYL
What is the function of this protein?
Inhibitor of the serine/threonine-protein kinase PAK4.  Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
What are the official names of this protein?
PAK4-inhibitor INKA1, Induced in neural crest by AP2-alpha protein homolog, MInca, Inka box actin regulator 1.
What is the protein family that this protein belongs to?
Belongs to the INKA family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly nuclear. Relocalizes to the cytoplasm following interaction with PAK4.
Protein: PFKA_STAAR
Sequence: MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQFINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1410_HAEIN
Sequence: MFREIQKSISDSVIQMLADQIEMLSLQAFFDVQKTQIIGQNGSRFTFAGLKTNITSIKSMTGIDVVWVEEGENVSKESWDILIPTIREDGSQIIVSFNPKNILDDTYQRFVIHPPERCKSVLVNWQDNPYFPKELMEDMEQMRERDYELYRHVYEGEPVADSDLAIIKPVWIEYAVDAHLKLGFTAKGMKKVGFDVADEGADSNANAFVHGSVVLDIEVWKNGDVIDSANRTNQSAVKFKADLIIFDSIGVGAGVKAHFKRLPKSLQVEGFNAGGAVAYPEREYIKGKKNQDMFSNIKAQSWWALRDRFYKTYRAVKYGDVYPDDELISLSSKIKELEYLKAELSRPRVDYDNNGRVKVESKKDMKKRGIPSPNMADALVMCYAPTKPKSLLDL
What are the official names of this protein?
Uncharacterized protein HI_1410.
Protein: LEPV_BACSU
Sequence: MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNELLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEPFLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNIVGVISDAE
What are the official names of this protein?
Signal peptidase I V, SPase I, Leader peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: VATB_CHLT2
Sequence: MQTIYTKITDIKGNLITVEAEGASLGELVQIERADGRSSYASVLRFDARKVTLQVFGGTSGLSTGDKVIFLGRPMEVIYGDSLLGRRFNGTGKPIDHEDECFGEPIPITTPSFNPVCRIVPREMVRTNIPMIDMFNCLVKSQKIPIFSSSGENHNALLMRIAAQTDADIVIIGGMGLTFVDYNFFVEESQRLGFADKCVKFIHKAVDAPVECVLIPDMALACAERFALEQQKNVLVLLTDMTAFADALKEIAITMDQIPANRGYPGSLYSDLAVRYEKAVDIAQGGSITLISVTTMPGDDITHPVPDNTGFITEGQFYLKDNRIDPFGSLSRLKQLVIGKKTREDHGDLANALIRLYADSRKSAERMSMGFKLSNWDKKLLAFSELFEARLMSLEVNIPLEEALDIGWKILSQSFHSEEVGIKEQLIQKYWPKACLHK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: ACOX3_HUMAN
Sequence: MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSLSRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADGELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL
What is the function of this protein?
Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
What are the official names of this protein?
Peroxisomal acyl-coenzyme A oxidase 3, Branched-chain acyl-CoA oxidase, BRCACox, Pristanoyl-CoA oxidase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA oxidase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: O164B_CONVE
Sequence: MKLTCVLIVAVLFLTACQLTTAASYARSEREHPDLGSSDQNSKLTKRCLASGETCWRDTSCCSFSCTNNVCF
What are the official names of this protein?
Conotoxin VnMKLT2-021.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GSHB_BUCAP
Sequence: MRKKKNLKIGIVMDSITLINIKKDSSFAILLEAQKRQHEIYYMEMNDLYLRKGQSYATTKSIEIQKNQNNYFKFIQKKDISLNELDAILMRKDPPFNTEFIYATYILERAEEKGVLVINKPKSLRDCNEKIFISWFSRFTTDTLVTRKLSKIHNFWKEKNDIILKPLDAMGGKGVFRIKKDDPNFSVIVETLTNYEKKYCMIQTYLPEVQFGDKRILIVNGKPIPWSLTRIPKHGETRANLAVGGEGRVQKLNDKDWEIANYLAPILKKRGLILVGLDVIGDKLTEINVTSPTCICEIEEKKNISITGILIDYIEDKIYK
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, GSHase, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic GSH synthase family.
Protein: RL5_PROMM
Sequence: MSLKQRYRETIQPKLLKDLSLSNIHEVPKVLKITVNRGLGEAAQNAKSLEASITELATITGQKVVVTRAKKAIAGFKIRQGMPIGCAVTLRGERMYAFLERLINLALPRIRDFRGVSPKSFDGRGNYTLGVREQLIFPEISFDKIDAIRGMDITIVTSARTDEEGQSLLREMGMPFRSN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: EXOS7_MOUSE
Sequence: MASVALSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSANATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLRSLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGAKDIELSDDPYDCIRLSVENVPCIVTLCKIGCRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMESSKRVGKVLHVSLQSLLHKEESLGPKRPRVGFLG
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  It seems to be involved in degradation of histone mRNA.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity).
What are the official names of this protein?
Exosome complex exonuclease RRP42, Exosome component 7, Ribosomal RNA-processing protein 42.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Nucleus.
Protein: YB96A_YEAST
Sequence: MSRVYIYPLTVFYFFAIEMSVFCYYNWFYRRNFPYLFRPIFPFLIVLIS
What are the official names of this protein?
Uncharacterized protein YBR196C-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y1249_ARCFU
Sequence: MLTRCMGRAFRLSTFFALTTAVTLGIFVISSVYLAHNGIKLPWTSAKIEEGVAHYSVDAITALAITIIAAIPLTAVTERFAKNGELRAYYISFSLILLFFAAVMILLFVNTCSLCSSSCSVRECGVEIALFNAEISCVCQ
What are the official names of this protein?
Uncharacterized protein AF_1249.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: URK_BACC2
Sequence: MGTNKPVVIGIAGGSGSGKTSVTKAIFDHFKGHSILILEQDYYYKDQSHLPMEERLKTNYDHPLAFDNDLLIEHLQQLLAYEQIDKPVYDYTLHTRSEEIIPVEPKDVIILEGILILEDPRLCELMDIKLFVDTDADLRILRRMQRDIKERGRTMDSVIDQYVTVVRPMHNQFIEPSKKFADIIIPEGGQNHVAIDIMVTKIATILEQKVNL
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_THESQ
Sequence: MKVVFVSYEVFPFAKVGGLADVAGTLPKYLKKHGVDVTIVMPKHRIVEKNAEKFGYEIKKVAEGLSVSHVKTDQKFDIYESVLPGSDVKTYFVANDYYFSAEDVYAGPDLGEQAIFFCAATLDLVKHLDLKPDIVHVNDWQTALIPVYLKTVYRDDPYFSRTATVLTIHNLGYQGVFDPKYLSFAGLPDYVFTIDGLEFYRQLNFLKGGIVFSDVINTVSPTYAEEIQTEEYGEKLEGVLRMRSKDLYGILNGIDYELYNPATDRYIYVNYDVNRLELKWENKVKLQEELGLPVNKETAVAGLISRLVPQKGLDLLVDVMDYLMLFDLQIVVLGTGDEQYENAFRKFQERYPDKVSANIKFDVELAQKIYAGADIFLMPSRYEPCGLGQMFSMRYGTIPVVRYTGGLADTVKEYDPQSMEGTGFGFKKYDSAHLLKAVSKALHFYYREKDHWRRIMTNAMNTDLSWDRSAKEYVDLYKKALAKVGR
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: ERIG_HERER
Sequence: MSVFAPIARELDIFFGFSWRDWSTTIIPGSIFAVGAMRDLPPATLVKNYLFLVTWLTPYIYFFNLSNQITGVDEDKINKPDRPIPSGKVTLQGAQRRWIAAFSTFLGIALYQPEFLPETLCWIATVAFLCLTSYGDHWFGKNCVAMTTGTWALLSASWKAIAPATPTSDAWVYAVSVWAGLITHIQDLRDMEGDKAVGRKTLPLVFGDMGSRLIITFFALPAACWVLSLAGIFQLAPVTLGALHAILGYRVLRQGGPRYDHKTYMFYTYIFCLILAFCALDGLGLKINAESLRALLATTGVSLKEL
What is the function of this protein?
Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of erinacines, cyathane-xylosides that show unique biological activities, including leishmanicidal activity, stimulating activity for nerve growth-factor synthesis, and agonistic activity toward the kappa opioid receptor (PubMed:31535864).  The geranylgeranyl diphosphate (GGPP) synthase eriE catalyzes the first step in erinacines biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:31535864).  GGPP is then substrate of the diterpene cyclase eriG for the production of cyatha-3,12-diene (PubMed:28371074).  EriG is unable to use geranyl diphosphate (GPP) or farnesyl diphosphate (FPP) as substrates (PubMed:28371074).  The cytochrome P450 monooxygenase eriI then hydroxylates cyatha-3,12-diene at C-14 of the seven-membered ring to produce erinacol, which is further hydroxylated at C-15 by the cytochrome P450 monooxygenase eriC to yield cyathadiol (PubMed:31535864).  The cytochrome P450 monooxygenase eriA then catalyzes C-11 hydroxylation in the presence of the short chain dehydrogenase/reductase (SDR) eriH, which leads to the production of cyathatriol (PubMed:31535864).  The acetyltransferase eriL converts cyathatriol into 11-O-acetyl-cyathatriol (PubMed:31535864).  The SDR eriH catalyzes further oxidation of 11-O-acetyl-cyathatriol into 1-O-acetylcyathin A3 (PubMed:31535864).  Finally, the glycosyl transferase eriJ tranfers xylose from UDP-xylose onto C-14 of 11-O-acetyl-cyathatriol to form eracine Q (PubMed:31535864).  EriJ is also able to convert 11-O-acetyl-cyathatriol to eracine Q2 by using UDP-D-glucose as cosubstrate, but at a lower rate (PubMed:31535864).  In the absence of eriL and eriJ, the SDR eriH is able to convert cyathatriol to cyathin A3; this is likely a switching mechanism in the biosynthesis of cyathins (C-14 ketogroup)and erinacines (C-14 glycosylated group) (PubMed:31535864).  The roles of the SDR eriB, the polyprenyl transferase eriF and the dehydrogenase eriK have still to be identified (Probable).
What are the official names of this protein?
Polyprenyl transferase eriG, Erinacine biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FOLD_RHILT
Sequence: MTTVIDGKNVAASVIQTVKSATAALEKSSGVTTGLAVVIVGDDPASHAYVGSKGRMAKECGFKSVQHTLPADTKQEDLAALVAALNADPSIHGILVQLPLPKPLDSEAIIQSILPEKDVDGLSVVNAGKLATGDLKTGLVSCTPAGAMVFVRRTHGEDLSGLNAVVIGRSNLFGKPMAQLLLNANATVTIAHSRTKNLAEVCRNADILVAAVGRPEMVRADWVKPGATVIDVGINRVAAPERGEGKTRLVGDVAFEEVSAVASTITPVPGGVGPMTIAMLMANTVIAAHRTAGQTPPQF
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PLSY_SULDN
Sequence: MDFLFNTNAQFFIAAYLIGAIPFGLLLAKKYAGVDVKSSGSGSIGATNVLRVVKQSNPALAKKLGAATLLLDALKGVLVLLFAYFYGVSEATLWGISVLAVLGHCYSPYLGFEGGKGVATGMGVMMFMLPLETIIALVVWALGAKFIRISSLSSLTALGALIVASFILHPDMAHAPVIIIGFVLLYKHIPNIIRLFKGEEKRVV
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PNS1_ASPFU
Sequence: MSGQAASYYNPSQSYGDFQPGMQNPQQQPDYYNNNVSNHGYDLNFQRGPEPKPPTEPPPTYNQAVYGFDDAFKIERPKYHDIWAGLLFIAVFLGYVAVSGVAIHRYAKYKGLNGDGIYDSSNSFSLDTNTLILFIFVLCVALAFSYAYFLGARYFSKLFIWVTGILNIVFALATGIYYIARKQYGGGIVFLLFGVFAIICFISWIPRIPFSAFMLQTSIDVSRKYGHMFIVSTIGGLVAVAFAAWFSVTLVSIYVAYEPSSSGSNPSCSDGGCSRARVIGLVVYVTFAMYWFSEWLKNTIHTTIAGVYGSWYFWSQSPNGMPRGSTRGAFRRATTYSFGSVSFGSLIIAIINMLRQACSVAQRNEAAEGSIVGSIMFWILGCFIAILDWLVTLFNRYAFCHIALYGKAYIPAAKDTWTMMRDRGIDALVNDCLIGPVLTMGSVFVSYVCALLAYLYLQFTKPSYNADGNFTAVIMAFAFVIGLQICQIFMTPVSSGIETIFVAMGWDPQVMIRDHPDLYYRMIQVYPRVQQAIQPSA
What is the function of this protein?
Probably involved in transport through the plasma membrane.
What are the official names of this protein?
Protein pns1.
What is the protein family that this protein belongs to?
Belongs to the CTL (choline transporter-like) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX3_NOCFA
Sequence: MTTAVGTPGSAITQRVHSLNRPNMVSVGTIIWLSSELMFFAGLFAMYFVARAQANGNWPPEPTELNLKLAVPVTAVLVASSFTCQMGVFAAEKGDVFGLRRWYFITLLMGAFFVAGQGYEYYHLVHEGTSISSSAYGSVFYITTGFHGLHVIGGLIAFVFLLIRTKVSKFTPAQATAAIVVSYYWHFVDIVWIGLFATIYFVR
What are the official names of this protein?
Probable cytochrome c oxidase subunit 3, Cytochrome aa3 subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.