PharMolix/UniProtQA huggingface dataset:
Protein: BIOB_GEOUR
Sequence: MENTIEALTGRIINGEAITHAEALELSQMEGSALFPLFCVANRIKEHFVGDKVYLCSIINAKSGRCPENCSFCAQSAHHKTDAPVYSLVDEDKMVACAHEAEKNGSSCYGIITSGTSINKGEELTRICRAVKRIRQETGITPSCSLGIIDYETALALKDAGVETYHHNLETARSFFPNVCTTHDYEEDVETVRVARKAGMKVCCGGIFGLGESIPQRVEMALTLRELDVDSVPLNFLNPIPGTRLENAVNITPMECLQTIALFRMILPSKKISVCGGREKNLRDLQSWIFFAGASGTMIGNYLTTTGRAAEEDWQMLKDLNLSAANCCD
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: ALKE_BABBO
Sequence: SKVVIATKVASRSSHLSWLRSGDCKLSKDNILKAVDGSLSRLNTDYIDLLQLHWPDRYVPMNANGDFHEVFHDTENMIDENSVPLEDQLDALQTLLTQGKIRHWGLSNETPWGTLRFYKLAKQAGVAAPASVQLHYNLLCRNEVEKGFVELCRPQNTGIAILAYAPLAGGILTGKYLEYMDPTTSGRLLRFPSYMSRYRGSLAARAVKDYYNIAMSYKYPNLCALALRWVLTRPFICSTVIGANDFYQLRENIHCSMPSLGITDLLEREINQLHWKWRDPIRICQ
What are the official names of this protein?
Aldo-keto reductase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Protein: RLMN_LISMF
Sequence: MEKSSIYGLTWTKLTEWLEAHGQKKFRATQVWDWLYRKRVKTFEEMSNVPKETIELLTANFVMNTLEEQVVQESTDGTTKYLFKLSDGNLIETVMMKQEYGLSVCVTTQVGCNIGCTFCASGLLKKSRDLTAGEIVEQIMNVQHYLDGRNLEERVSHVVVMGIGEPFDNYDNVMDFLRVINHDKGLAIGARHITVSTSGLAPRIIDFANEDFQVNLAISLHAPNNELRTSIMRINKTYSIEKLMEAIHYYVNKTNRRITFEYIMLKGVNDHKKEALELAALLGEHRHLAYVNLIPYNPVDEHIDYERSTKEDVLAFYDTLKKNGINCVIRREHGTDIDAACGQLRSKQIKRVGVRERMKQKQAAAEE
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAOK_SCHPO
Sequence: MSFSKFHCGKLMSLKLADLRTMFEALEK
What are the official names of this protein?
Uncharacterized protein SPAC11D3.20.
Protein: COBS_CLOAB
Sequence: MAFFRRLILMIQFLTRIPIKYESDITTEDFGKALALVPIVGLIIGGIMGVTYMLLVKVFFYKISAVLVLIEYIFLTGGIHLDGLGDTFDGVFSNRPKERILEIMRDSRVGTNAVLAVISVIILNYVILTEIDPAYMVKVIILFPVAGRLGSIVSASLSTYARRGEGMGKSFIDYCTLKELAIGIILYAVIFLSVGLSRGYIIMIFPILTAVILIKYFTRKIGGATGDILGAVCELNQTFYLMTVYAVLYFRG
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AZOR7_BURL3
Sequence: MKLLHIDSSILGQGSVSRELSAEVVATFRARDPGLTVTRLDLAATPIGHLSAEHLAAAQGAPISDALKADVEIGQRALAEFLAADIVVIGAPMYNFGIASQLKAWIDRISVAGTTFRYGENGPVGLCGGKKLVVASSRGGVYSEGSPAAAFDHQETYLKAAFGFLGITDITFIRAEGVAMGPDLRSGAIASAKEAAAALAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 7, Azo-dye reductase 7, FMN-dependent NADH-azo compound oxidoreductase 7, FMN-dependent NADH-azoreductase 7.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: YRN8_CAEEL
Sequence: MTHLLLLLFFSCVQLTTGQFYCADLIQQCAKSAAEYTEQILQYKESAFKSCVRRPACHTERKIFDECFDASVSATHISPPQESTSNDGETRKVTQPPMVKYNSLLKFFTEKSMNFRSALDQCFVRSPFVPKRNFFGPSILDEDAAYARAIYQFDLADRLWGLPELSVTRPSLDTLGVCRTQNTALRVFGSGISRIARASDPKKNNLTSSCMLDEDEITCYRQALDLNSEYIQLIYNRDYALRACIQNLRQQSVCRMNDKSRLRSCLCGVREQYDNDVQAGILQCVKSKSPHIPAMVIEMSSSLDEEPTSAKIQEQVTPAQLTFDTPGAIVNGQCMCACEHSAKNEATRLFANKKNNNDVEKSTQIEKKPEKQGPEIQEEVVEMETVKDEQPPKTSAVRFKENSPRLMQPSEAAGRVFWMNNITIT
What are the official names of this protein?
Uncharacterized protein R07B1.8.
Protein: TOLQ_ECOLI
Sequence: MTDMNILDLFLKASLLVKLIMLILIGFSIASWAIIIQRTRILNAAAREAEAFEDKFWSGIELSRLYQESQGKRDNLTGSEQIFYSGFKEFVRLHRANSHAPEAVVEGASRAMRISMNRELENLETHIPFLGTVGSISPYIGLFGTVWGIMHAFIALGAVKQATLQMVAPGIAEALIATAIGLFAAIPAVMAYNRLNQRVNKLELNYDNFMEEFTAILHRQAFTVSESNKG
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity (PubMed:1683466, PubMed:17233825).  Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction (PubMed:11722743).  The Tol-Pal system is also required for polar localization of chemoreceptors clusters (PubMed:24720726).  The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity (PubMed:32152098).  Is involved in the uptake of group A colicins (colicins A, E1, E2, E3, and K) and in the uptake of filamentous phage DNA (PubMed:1683466, PubMed:3294803).
What are the official names of this protein?
Tol-Pal system protein TolQ.
What is the protein family that this protein belongs to?
Belongs to the ExbB/TolQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity.
Protein: PFKA_BACVZ
Sequence: MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYSGLISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIENLKKLGIEGLVVIGGDGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMQEIIGRLKRGHDRGKKHSIIIVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSASDRVLASRLGAYAVELLLKGKGGRCVGIQNNKLVDHDIIEILESKHTVEPNMYQLSKELSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPBG_BACSU
Sequence: MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGKPPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHFGVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEMDHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYELGKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE
What are the official names of this protein?
Uncharacterized protein YpbG.
Protein: ATPI_CRUWA
Sequence: MNVLSCSINTLIKEGLYEISGVEVGQHFYWQIGGFQVHAQVLITSWVVIAILLGSAVLAIRNPQTIPTDGQNFFEFVLEFIRDVSKTQIGEEYGPWVPFIGTLFLFIFVSNWSGALLPWKIIQLPQGELAAPTNDINTTVALALLTSVAYFYAGLSKKGLGYFSKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ABCGO_DICDI
Sequence: MIIFKNNEIRFNSILKSILLLLLLFINGNNCKTAQQFLDENFNHALFREHQLEKEYKTKQLVKDDPNMYSDWTEVPAATAEAVTIMRGDDYYYDYDKEQKIEMIVFGSENAISSGSAQNYWYGQTCEATNFNNTPTTTCPNDCHSYWGQGQCNETSSTCICNYFFIGDDCSENVDPQHNWDKMNCNGGRYCPPIYNYPTPRSCVCPPGQAGLECTVCLNNEGCQALTGNYSSSFECNSSPYTYFEKSYSCVVTSAEVNGDLNNSTASASIDCQFPGGNYNTQTGVCSMNLYYRIHGSPLYFNCSFTECDRTILPGQNQSIVCQNSVCNCTTYCGFILDGLISAVTGEATFECGAQTNPDGTSNCLFSQYTINQMLPAIPLQCMSGECIDVATGAPTPPPIYPVPVASMSFLYIYVGSGVGFIGLTLLIGAIFLIFSLQEDRKNFKEDTHLVCELSFHNISCYVNERSGFFGKDVKRKQILDNVNGVCPPGQLTALMGLSGSGKTSLLDILSGRKNVGNIDGKVLINGAPVGKNFKRISGYVTQDDIQIGTLTCREHLMFAALLKLPENMSLEIKQQRVASVLEELGLTRVADNPIGTSEKRGISGGERRRLSIATELIVDPSILFIDEPTSGLDSHSASELITKLKQLANNSTKGQRTIIFSIHQPSAELFEQFDNLILLHQGNPYFSGKREDSVNYFIKQKIAGMTEFEQQNYRMHLKNPADFIISMVTDKNCQRFNSTYVDSRVASPFYQSTSPALSSNSNNSDINLNHHRIINNPHNQNIHHQQHHHHHRHIYGINGPSIDNNDSDSDSDERDHLLASDNINNNNNNNKVKNNDNNNKNNDDDVEDIEEASPIIVVGNQGEPLASHIKIGKVEEYATSFWTQFFVVCRRSLLNYMRNPFLLRTTYFVHIFVGLTLGYLFWKLPANLEPGCQNRFGAMFFMTALLSFGSITSLDLFYNDRIIFIRERANGFYRTSAYFLAKVVTDIIPMRVIPPIILGSICYYMIGLRPGILHFIYFLISLVLTSTVASSMCMAISTISPTFGTANMVSILLLFVFLLFDGFLLARSSIPKYLIGLVWISFMSYGLEIPVVNEFNGLWIEYNPPNTRPTYADGLEFLSTIGANPNRLFTDMYVLLGMIVGYLLLAYVFLRFLVREYR
What are the official names of this protein?
ABC transporter G family member 24, ABC transporter ABCG.24.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL29_SYNP2
Sequence: MPLPKIEDARKLNDQELADEIVAVKKQLFDLRLQQGTGRLEKTHEIKHARHRLALLMTVERQRQLQAQ
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: YIHY_ECOLC
Sequence: MLKTIQDKARHRTRPLWAWLKLLWQRIDEDNMTTLAGNLAYVSLLSLVPLVAVVFALFAAFPMFSDVSIQLRHFIFANFLPATGDVIQRYIEQFVANSNKMTAVGACGLIVTALLLMYSIDSALNTIWRSKRARPKIYSFAVYWMILTLGPLLAGASLAISSYLLSLRWASDLNTVIDNVLRIFPLLLSWISFWLLYSIVPTIRVPNRDAIVGAFVAALLFEAGKKGFALYITMFPSYQLIYGVLAVIPILFVWVYWTWCIVLLGAEITVTLGEYRKLKQAAEQEEDDEP
What are the official names of this protein?
UPF0761 membrane protein YihY.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PABP1_PONAB
Sequence: MNPSAPSYPMASLYVGDLHPDATEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
What is the function of this protein?
Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability.  Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2.  Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.  Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs.  Involved in translationally coupled mRNA turnover.  Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.  Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.  By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability.
What are the official names of this protein?
Polyadenylate-binding protein 1, PABP-1, Poly(A)-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the polyadenylate-binding protein type-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, Stress granule. Nucleus. Cell projection, lamellipodium. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Shuttles between the cytoplasm and the nucleus (By similarity). During stress and in the absence of DDX3X, localizes to the nucleus (By similarity). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (By similarity). Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with ENDOV (By similarity).
Protein: P2C39_ORYSJ
Sequence: MVDEELFDKSSNDHSISSEEEDMLVRSYSNLNVSFGYHCNSYQCFSLDTDEYDISPNKRLETNTMMTSQNGSFTCLSGAAISANFTLANTNICKGLIGEEILPELDSPNSFRKIVSSPSMSRLDLLSTSQGSPVSTESSIFEISKNIWRSSAPTTVSSNFLTSTEIKMAGGAAGEDRVQAVCSEKNGWLICGIYDGFNGRDAADFLAVTLYDNIVYYLYLLECRIKQENGLYGSPEGSLNGVKSELTLAMRFAENEDVKFSETFRAGVLKCLTTAVEQAENDFLCMVEQEMDDRPDLVSVGSCVLVVLLHGTDLCILNLGDSRAVLASVPSSGMDKLKAVQLTEIHSLENPLEYQKLLADHPNEPSVVMGNKIKGKLKVTRAFGVGYLKQKKLNDALMGILRVRNLCSPPYVYTNPHTVSHKVTEDDLFVVLGSDGLFDFFSNDEVVQLVYQFMHDNPIGDPAKYLIEQLLLKAAKEAALTAEELMRIPVGSRRKYHDDVTIIVIILGNAQRTMTASTSL
What are the official names of this protein?
Probable protein phosphatase 2C 39, OsPP2C39.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: IF1_STRSY
Sequence: MAKEDVIEIEGKVVDTMPNAMFTVELENGHQVLATVSGKIRKNYIRILVGDRVTVELSPYDLTRGRITYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_ECOSE
Sequence: MSKPFKLNSAFKPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKAMLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQYARNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQIVSTIPRFTIYPKTHYVTPRERIVQAMEEIKEELAARRKVLLENNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGDVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGRGKSRPIVEPDNVPMDMSPKALQQKIHELEGLMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBG6_ARATH
Sequence: MHYMGLFSRAGNIFRQPRALQASNAMLQGNLSLTPSKIFVGGLSPSTDVELLKEAFGSFGKIVDAVVVLDRESGLSRGFGFVTYDSIEVANNAMQAMQNKELDGRIIGVHPADSGGGGGGGGFARRGGYGGGRGGYARGGFGRGGFGGGGYGFVR
What is the function of this protein?
Possibly has a role in RNA transcription or processing during stress.
What are the official names of this protein?
Glycine-rich RNA-binding protein 6, mitochondrial, AtGR-RBP6, AtRBG6.
What is the protein family that this protein belongs to?
Belongs to the GR-RBP family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RDH10_RAT
Sequence: MNIVVEFFLVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPPCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI
What is the function of this protein?
Retinol dehydrogenase with a clear preference for NADP.  Converts all-trans-retinol to all-trans-retinal.
What are the official names of this protein?
Retinol dehydrogenase 10.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: QUEA_PARMW
Sequence: MPDPRDLQLSSYDYPLPQERIAQVPAEPRHSARMLMVPPATQALEAARHGVVWDLLEELQPGDLLVVNNTRVLKARLKVRRSGGGLSELLVLEPRGEGRWLCLARPAKRMRPGDVLTIDGTSIGLTVLEDDAASGGRLVQFPTDCRDAETIETLLNQWGEVPLPPYIDRHDPDDVERYQTRYADRPGAVAAPTAGLHFSDELLAGLQLKGVELARITLHVGLGTFRPVETNDLTRLELHSEWVEVSAAVVEAIQRCRGRVIAVGTTSVRALEGAAQQNGGVLQPFTGPVNLVIQPGYRFAVVQGLMTNFHLPKSSLLLLVSALIGREKLLAIYTEAIERNYRFFSYGDAMWIAPEAVLSQAEPVGH
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAP1_MALGO
Sequence: MQLSIQAIIGFVVAAGLAVASELPSPMTVNLERRKMLVTKNDTVDFKAVRKQANALNYKYDKLLRNFRKNTGRDHPLLHLLLDLIDKRDGKGDVDLDDIGEGQLWAGDVQFGQSKFKIDFDTGSADTLVNPFVYFPHRSKSSRKTHHTFSTAYGDGTTASGFIYTDDLKIGGYKAKDVAIGLSVTKFINDEDNQGIAGMSFPAVQSFPKKFDPFFVALVKQKVVPEPVFQFTLKRGSGSTLHLGGIDNSRFQGELSYVDVNPEDGFWISEGKVNGKKIDACIDTGSSIIFGPIDEVREVITKMDGVTPFTAGGALHGAFDCSKPPKLDFEFAGQKFNLGENQVSFGKYQGQCVLSIMGQKNLPMNAWVVGDSFLQTASVVFDMGKNRMGFAPSSN
What is the function of this protein?
Dominant secreted aspartyl protease that has a clear preference for aromatic residues in the P1' position directly adjacent to the cleavage site and, in particular, Trp.  In addition, it generally cleaves peptides containing Lys, Arg, Phe, Tyr, or Nle (norleucine) in the P1 position, Nle and Glu at P2, and Arg and Val at P2'.  Has important roles in facilitating the interaction of the yeast with the external environment (PubMed:29246799).  Is able to rapidly hydrolyze Staphylococcus aureus protein A, an important S. aureus virulence factor involved in immune evasion and biofilm formation.  Shows anti-biofilm properties and thus plays a role in inter-kingdom interactions, beneficial for host skin health (PubMed:29246799).
What are the official names of this protein?
Secreted aspartyl protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEUC_MYCBT
Sequence: MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: SSRP_SHEDO
Sequence: MVKKNSKSAKNASATIARNKRATFEYRIEDKIEAGLQLMGWEVKSIRMGKVNLSDCYVYIKEGEAFMHGCTIQPLNTASTHVVCDPIRTKKLLLKRSEIDKLAGLIERQGYTLIPLSMYWRKGAWVKVEIGLGKGKKDHDKREDTKEREWKIEKARVMKKDKVGA
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ILVD_STAA2
Sequence: MRSDMIKKGDHQAPARSLLHATGALKSPTDMNKPFVAICNSYIDIVPGHVHLRELADIAKEAIREAGAIPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADAAETVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAIFCSGGPMKAGLSAHGKALTLSSMFEAVGAFKEGSISKEEFLDMEQNACPTCGSCAGMFTANSMNCLMEVLGLALPYNGTALAVSDQRREMIRQAAFKLVENIKNDLKPRDIVTREAIDDAFALDMAMGGSTNTVLHTLAIANEAGIDYDLERINAIAKRTPYLSKIAPSSSYSMHDVHEAGGVPAIINELMKKDGTLHPDRITVTGKTLRENNEGKEIKNFDVIHPLDAPYDAQGGLSILFGNIAPKGAVIKVGGVDPSIKTFTGKAICFNSHDEAVEAIDNRTVRAGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKDVALITDGRFSGATRGIAVGHISPEAASGGPIALIEDGDEITIDLTNRTLNVNQPEDVLARRRESLTPFKAKVKTGYLARYTALVTSANTGGVMQVPENLI
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CL029_MOUSE
Sequence: MKRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKALDADVYNAVATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKESAKEFHWNTEEDFKPVPECWIPAKEIEKQNGKPVPDENGHIPGWVPVEKGSKQYCWHSSVVNYEFGIALVLRHHPDDPGVLEISAVPLSELLEQTLELIGTSINGNPYGLGSKKSPLHFLTPHGAFQVRNLPTLKHNDLLSWFEDCREGQIEGIVWHCGDGCLIKVHRHHLGLCWPLPDTYMNSKPVIINMNLNLNNYDCAFDNQSLFNQFSKIDKQKFERLKDIILDV
What are the official names of this protein?
Uncharacterized protein C12orf29 homolog.