PharMolix/UniProtQA huggingface dataset:
Protein: ETFR1_HUMAN
Sequence: MKMANSLRGEVLKLYKNLLYLGRDYPKGADYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKELEALYFLRKYRAMKQRYYSDTNKTN
What is the function of this protein?
Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB).
What are the official names of this protein?
Electron transfer flavoprotein regulatory factor 1, LYR motif-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y014_METJA
Sequence: MMIMERHYTLKEASKILGVSIKTLQRWDKAGKIKCIRTLGGKRRVPESEIKRILGIKDKEQRKIIGYARVSFNAQKDDLERQIQLIKSYAEENGWDIQILKDIGSGLNEKRKNYKKLLKMVMNRKVEKVIIAYPDRLTRFGFETLKEFFKSYGTEIVIINKKHKTPQEELVEDLITIVSHFAGKLYGMHSHKYKKLTKTVKEIVREEDAKEKE
What are the official names of this protein?
Uncharacterized protein MJ0014.
Protein: LIPA_CERS4
Sequence: MIGKLVRDLKIPDQRHPEKAHRPDNVQPKKPSWIRVKAPTSEGYKETRDIIRGQKLATVCEEAGCPNVGECWSQGHATMMIMGEICTRGCSFCNVATGRPQALDAFEPGRVAHAVSQLGLKHVVVTSVDRDDLEDGGAEHFAQTIRAIRHRAPATTIEVLVPDFLKCGPSALETVVAARPDVFNHNLETVPGLYPEVRPGARYFHSLRLLQRAKELDPSIFTKSGIMVGLGEDRQGVLQVMDDMRSAEVDFLTIGQYLQPTPKHHRVDRFVTPEEFAGYEKAAYGKGFLMVSATPLTRSSYHAGDDFARLRDARQKRLGA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OADG2_SALTI
Sequence: MTNAALLLGEGFTLMLLGMGFVLAFLFLLIFAIRGMSAVITRFFPEPVAAPAPRAVPAVDDFTRLKPVIAAAIHHHRLNA
What is the function of this protein?
Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
What are the official names of this protein?
Oxaloacetate decarboxylase gamma chain 2.
What is the protein family that this protein belongs to?
Belongs to the OadG family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: GSA_ACTP2
Sequence: MSKSEQLFEKAQKVIPGGVNSPVRAFKGVGGTPVFIQKAEGAYITDSDGKKYIDYVGSWGPMVLGHNHPAIIDAVLKAVPNGLSFGAPTESEITLAELVTKLVPSIELVRMVSSGTEATMSAIRLARGYTGRDKIIKFEGCYHGHSDSLLVKAGSGALTLGQPSGPGVPADFAKHTLTCTYNDLDSVKTAFEQYPNEIACLIVEPVAGNMNCIPPKNDFLKGLRALCDQYGAVFIIDEVMTGFRVALGGAQAYYDVKPDLTTLGKIIGGGMPVGAFGGKKEIMEYIAPTGPVYQAGTLSGNPIAMAAGLACLTELSKAGNEEKLAAQTKTLAEGFKALADKHNVLFTAQYVGGMFGLFFTEQAEITNFQEVMKCDAAKFNRFFHLMLEQGVYLAPSAFEAGFMSLAHSDEDIQATLAAADKAFAQL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C90B1_ARATH
Sequence: MFETEHHTLLPLLLLPSLLSLLLFLILLKRRNRKTRFNLPPGKSGWPFLGETIGYLKPYTATTLGDFMQQHVSKYGKIYRSNLFGEPTIVSADAGLNRFILQNEGRLFECSYPRSIGGILGKWSMLVLVGDMHRDMRSISLNFLSHARLRTILLKDVERHTLFVLDSWQQNSIFSAQDEAKKFTFNLMAKHIMSMDPGEEETEQLKKEYVTFMKGVVSAPLNLPGTAYHKALQSRATILKFIERKMEERKLDIKEEDQEEEEVKTEDEAEMSKSDHVRKQRTDDDLLGWVLKHSNLSTEQILDLILSLLFAGHETSSVAIALAIFFLQACPKAVEELREEHLEIARAKKELGESELNWDDYKKMDFTQCVINETLRLGNVVRFLHRKALKDVRYKGYDIPSGWKVLPVISAVHLDNSRYDQPNLFNPWRWQQQNNGASSSGSGSFSTWGNNYMPFGGGPRLCAGSELAKLEMAVFIHHLVLKFNWELAEDDKPFAFPFVDFPNGLPIRVSRIL
What is the function of this protein?
Catalyzes the C22-alpha-hydroxylation step in brassinosteroids biosynthesis (PubMed:9490746, PubMed:16460510).  Converts campesterol (CR) to (22S)-22-hydroxycampesterol (22-OHCR, 22-hydroxyCR), campestanol (CN) to 6-deoxycathasterone (6-deoxoCT), and 6-oxocampestanol (6-oxoCN) to cathasterone (CT) (PubMed:9490746, PubMed:16460510).  Can also use cholesterol and cholestanol as substrates (PubMed:9490746, PubMed:16460510).
What are the official names of this protein?
Steroid (22S)-hydroxylase, (22S)-22-hydroxycampesterol synthase, 6-deoxycathasterone synthase, Cathasterone synthase, Cytochrome P450 90B1, AtCYP90B1, Protein DWARF 4, Dwarf4, Steroid 22-alpha-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RELA_PHOAS
Sequence: MVAVRGAHLKENTTFELVSWVESLRQDAKVSSRIEGTYQRCIELAAEQENGPLLLWRGRELVEILVTLSMDADTLIAALLYPLVEGGCYSTDALKEEYSGTILHLVQGVEQMCAISQLKSTAEETAQAAQVDNIRRMLLSMVDDFRCVVIKLAERICNLREVKDQPDEVRRAAAQECANIYAPLANRLGIGQLKWEIEDYAFRYQHPDTYKQIAKQLSERRIDREDYITHFVDDLSDAMKASNIRAEVQGRPKHIYSIWRKMQKKSLEFDELFDVRAVRIVAEELQDCYAALGVVHTKYRHLPKEFDDYVANPKPNGYQSIHTVVLGPEGKTIEIQIRTKQMHEESELGVAAHWKYKEGTASGGAQSAYDEKINWLRKLLAWQEEMSDSGEMLDELRSQVFDDRVYAFTPKGDVVDLPSNATPLDFAYHIHSEVGHRCIGAKVEGRIVPFTYHLQMGDQVEIITQKEPNPSRDWLNPNLGFVTSSRARAKVHAWFRKQDRDKNIIAGKEILEAELVKIHATLKDAQYYAAKRFNVKSPEELYAGIGSGDLRINQVINHINALVNKPTAEEEDQQLLEKLSEASNKQATSHKKPQRDAVVVEGVDNLMTHLARCCQPIPGDDIQGFVTQGRGISVHRMDCEQLEELRHHAPERIIDTVWGGGFVGNYTITVRVTASERNGLLKELTNTLMNEKVKVAGMKSRVDYKKQMSIMDFELELTDLEVLGRVLKRIEQVKDVAEAKRLYG
What is the function of this protein?
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.  This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp.  Also plays a role in the reductive division that occurs during the initial phase of nutrient starvation.
What are the official names of this protein?
GTP pyrophosphokinase, (p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: EIL1A_ORYSJ
Sequence: MMGGGLVMDQGMMFPGVHNFVDLLQQNGGDKNLGFGALVPQTSSGEQCVMGEGDLVDPPPESFPDAGEDDSDDDVEDIEELERRMWRDRMKLKRLKELQLSRGKDPAGGVVGDPSKPRQSQEQARRKKMSRAQDGILKYMLKMMEVCRAQGFVYGIIPEKGKPVSGASDNLRGWWKEKVRFDRNGPAAIAKYQADNAVPGFESELASGTGSPHSLQELQDTTLGSLLSALMQHCDPPQRRYPLEKGVPPPWWPTGDEEWWPELGIPKDQGPPPYKKPHDLKKAWKVSVLTAVIKHMSPDIEKIRRLVRQSKCLQDKMTAKEISTWLAVVKQEEELYLKLNPGARPPAPTGGITSAISFNASSSEYDVDVVDDCKGDEAGNQKAVVVADPTAFNLGAAMLNDKFLMPASMKEEATDVEFIQKRSASGAEPELMLNNRVYTCHNVQCPHSDYGYGFLDRNARNSHQYTCKYNDPLQQSTENKPSPPAIFPATYNTPNQALNNLDFGLPMDGQRSITELMNMYDNNFVANKNLSNDNATIMERPNAVNPRIQIEEGFFGQGSGIGGSNGGVFEDVNGMMQQPQQTTPAQQQFFIRDDTPFGNQMGDINGASEFRFGSGFNMSGAVEYPGAMQGQQKNDGSNWYY
What is the function of this protein?
Transcription factor acting as a positive regulator in the ethylene response pathway (PubMed:16786297, PubMed:28829777, PubMed:27701783, PubMed:25995326).  Required for the inhibition of root growth by ethylene in etiolated seedlings (PubMed:25995326, PubMed:28829777).  Functions upstream of the auxin biosynthetic gene YUCCA8 and directly activates its expression (PubMed:28829777).  Functions downstream of the ethylene signaling factor EIN2 in disease resistance against the rice blast fungus (Magnaporthe oryzae) (PubMed:27701783).  Binds directly to the promoters of the NADPH oxidases RBOHA and RBOHB, and the jasmonate biosynthetic gene OPR4 to activate their expression during fungal infection (PubMed:27701783).  May enhance disease resistance by facilitating reactive oxygen species (ROS) generation and jasmonate biosynthesis with subsequent phytoalexin accumulation during Magnaporthe oryzae infection (PubMed:27701783).  Acts as negative regulator of salt tolerance (PubMed:25995326).  During salt stress, activates the cation transporter HKT1, which mediates increased sodium uptake in roots, and contributes to sodium accumulation and salt toxicity (PubMed:25995326).  Binds directly to the DNA sequence 5'-TGTTACAAATACC-3' in the promoter of the GA20OX2 gene to activate its expression at the transcriptional level during ethylene signaling (PubMed:30002253).  Possesses transactivation activity in protoplasts (PubMed:25995326).
What are the official names of this protein?
Protein ETHYLENE-INSENSITIVE 3-like 1a, EIN3-like protein 1a, OsEIL1a, OsEIL1, Protein MAO HUZI 6.
What is the protein family that this protein belongs to?
Belongs to the EIN3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BSC9_ALTBR
Sequence: MASTSSTSTDGHLNIRPMVHGSDKKLNFGAYITGLDLNNASDAEVDQLREAILRHKIVVIKGQQAEKPDKNWEMIKKLDPMHHMITQEEFGQLFHPTGEGLIAMLKLATVPTTEHGHIHLMGKGYQGDDHYGLKKLNLGEAFAGNYYSKPLAEEDFRAGVTRFQSWHMDGPLYKVHPPYISSLRFIQLPDGEQTVEWADGSGLSLKTKPGRTAFFSTSQLYDMLTDEERAMVDNSAVEYMYYPYEWIRGCRGNPNGLNVADEGREKPLDAMEEIARDERWTKTYPMVWFNELTKEKSLQVQPNCVRRLLIRRSADQKEPEIIEGPERVREFMNKLQQRIVRPEYVYVGPEEEGDHVFWYNWGMMHSKIDYPIAYGPRIVHQGWIPSHRVPRGPTAVAH
What is the function of this protein?
Alpha-ketoglutarate dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of the diterpene glucoside brassicicene C (PubMed:21299202).  In the first step of the brassicicene C biosynthesis, the bifunctionnal diterpene synthase bsc8 that possesses both prenyl transferase and terpene cyclase activity, converts isopentenyl diphosphate and dimethylallyl diphosphate into geranylgeranyl diphosphate (GGDP) that is further converted into fusicocca-2,10(14)-diene, the first precursor for brassicicene C (PubMed:19097780).  Fusicocca-2,10(14)-diene is then substrate of cytochrome P450 monooxygenase bsc1 for hydroxylation at the C-8 position (PubMed:19700326).  Oxidation at C-16 position to aldehyde is then catalyzed by the cytochrome P450 monooyxygenase bsc7, yielding fusicocca-2,10(14)-diene-8-beta,16-diol (PubMed:19700326).  Follows the isomerization of the double bond and reduction of aldehyde to alcohol catalyzed by the short-chain dehydrogenase/reductase bsc3 to yield the diol compound fusicocca-1,10(14)-diene-8 beta,16-diol (Probable).  The next step is the oxidation at the C-3 position of fusicocca-2,10(14)-diene-8-beta,16-diol catalyzed by the alpha-ketoglutarate dependent dioxygenase bsc9, to produce a triol compound (PubMed:21299202).  Methylation of the hydroxy group at position 16 is performed by the methyltransferase bsc6 (PubMed:19097780).  16-O-methylation is followed by oxidation at the C-13 position to ketone and an alkyl shift of the methyl group leads to brassicicene C (Probable).  Although the probable acetyltransferase bsc4 is included in the gene cluster, no acetylation reactions are necessary for brassicicene C biosynthesis.  However, the fact that brassicicene E, which is a structurally related compound having an acetoxy group at position 12, was previously isolated from another strain of A. brassicicola suggests that the ATCC 96836 strain might also produce a small amount of brassicicene E (Probable).
What are the official names of this protein?
Alpha-ketoglutarate-dependent dioxygenase bsc9, Brassicicene C biosynthetic gene cluster protein 9, Brassicicene-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
Protein: THIE_XYLFA
Sequence: MEVSRIGSFQEHIDKTTGIVTPHPLLRKPLMSQPRGIYLITPDETDTARLIARTAPLLNGIVWLQYRNKLANTALRTEQAQALLALCRQTGIPLLINDDLELAQTIGADGVHLGMHDSNPSIARAQLGPHAIIGVSCYNQIERAKQAIKAGASYVGFGTFYPSHTKTTPYRATPELLRQTTHLGVPRVAIGGLTPKNIAPIIEAGAELLAVISGIYSAKNPVTALKAYQSQFNI
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: KIRR3_MOUSE
Sequence: MRPFQLDLLFLCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPIILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPSSGREAEDHTTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPTGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV
What is the function of this protein?
Synaptic adhesion molecule required for the formation of target-specific synapses (PubMed:23637329, PubMed:26575286).  Required for formation of target-specific synapses at hippocampal mossy fiber synapses.  Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons.  Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation (PubMed:26575286).  Required for the coalescence of vomeronasal sensory neuron axons (PubMed:23637329).  May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells (PubMed:12665856).
What are the official names of this protein?
Kin of IRRE-like protein 3, Kin of irregular chiasm-like protein 3, Nephrin-like protein 2, mKirre.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. SUBCELLULAR LOCATION: [Processed kin of IRRE-like protein 3]: Secreted.
Protein: ALLB_SALG2
Sequence: MSFDLIIKNGTVILENEARVIDIAAQGGKIAAIGENLGEAKNVLDATGLIVSPGMVDAHTHISEPGRTHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRETIELKFDAAKGKLTIDAAQLGGLVSYNLDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFYKGAQKLGEMDQTVLVHCENALICDELGEEAKREGRVTAHDYVASRPVFTEVEAIRRVLYLAKAAGCRLHVCHISSPEGVEEVTRARQEVQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDQENQKGMWEKLFNGEIDCLVSDHSPCPPEMKAGNIMQAWGGIAGLQNCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLKHKGRIAPGKDADLVFIQPDSSYVLKNEDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEHGFPVPPKGQFILKHQQ
What is the function of this protein?
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
What are the official names of this protein?
Allantoinase, Allantoin-utilizing enzyme.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
Protein: NANK_ECODH
Sequence: MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNLGGLLHFPLVKTLEQLTNLPTIAINDAQAAAWAEFQALDGDITDMVFITVSTGVGGGVVSGCKLLTGPGGLAGHIGHTLADPHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGADAKTIFTRAGQGDEQAQQLIHRSARTLARLIADIKATTDCQCVVVGGSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.
Protein: MNHB2_STAAC
Sequence: MKENDVVLRTVTKLVVFILLTFGFYVFFAGHNNPGGGFIGGLIFSSAFILMFLAFNVEEVLESLPIDFRILMIIGALVSSITAIIPMFFGKPFLSQYETTWILPILGQIHVSTITLFELGILFSVVGVIVTVMLSLSGGRS
What are the official names of this protein?
Putative antiporter subunit mnhB2, Mrp complex subunit B2, Putative NADH-ubiquinone oxidoreductase subunit mnhB2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TYSY_PSEA7
Sequence: MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGYQMRFDLAAGFPLVTTKKCHLKSIVHELLWFLQGSTNIAYLKEHGVSIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLMTMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVAGLRPGEFIWTGGDCHLYANHLEQADLQLTREPLPLPSMKLNPEVKDLFDFRFEDFELVGYQAHPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_PROMT
Sequence: MEKPFGFVVIDKPSGLTSHDCVNRLRKVFGIKKIGHSGTLDPAVTGVLPIAIGDATRLISYLQGSKAYRGIIQLGATTNTDDMQGEIIESKAWPLITQNYINYLLENFRGEILQKPPIFSSVHIKGERAYKKARKGEKFDLIPKKVTINKLNLISWSQDKGELLVDVDCSTGTYIRSLARDIGDKIGCGGYLKSLRRTKAYNFIENHSVKLPEKSDFYPEGDKPKVLNPNIFFKHLSSFELISEEEIISWRSGRKISFQNNVKRLKVTKNNEVEDSFIHNNHILVLNKENKILGIACLDDSFAIKPKVVFNAIG
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: HBA_MONDO
Sequence: MVLSAADKTNVKAAWSKVGGNSGAYMGEALYRTFLSFPPTKTYFPHFEFSAGSAQIKGQGQKIADAVSLAVAHMDDLATALSALSDLHAHNLKVDPVNFKFLCHNVLVTLASHLGKDFTPEIHASLDKFLALLSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PHNX_BACCQ
Sequence: MKIEAVIFDWAGTTVDYGCFAPLEVFIKIFRKRGVKITDEEARKPMGLLKIDHVRALTEMPRIANEWERVFGHLPTEADIHEMYEEFEEILFTILPHYATPIDGVKEVVASLRKRGLKIGSTTGYTREMMDIVAKEAEIQGYKPDVLVTPDDVSAGRPYPWMCYKNAMELGVYPMNHMIKVGDTVSDMKEGRNAGMWTVGVILGSSELGLSEWAAETMDPVELREKMEVVRKRFVENGAHFTIETMQGLENVIEQIEKQEFIIS
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
Phosphonoacetaldehyde hydrolase, Phosphonatase, Phosphonoacetaldehyde phosphonohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PhnX family.
Protein: PPK5_EURFL
Sequence: GGGGSGETSGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, EurFl-Capa-PK, FXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HSLU_AZOC5
Sequence: MSDFSPREIVSELDRHIVGQGKAKRAVAIALRNRWRRQQLQGHMREEVLPKNILMIGPTGVGKTEISRRLARLAGAPFLKVEATKFTEVGYVGRDVEQIIRDLVEVGIGLVREQKRKDVQARAHLAAEERVLDALVGANSSSTTRDAFRKKLRAGELDEKEVEIEVQAGAQGMPMFEIPGMPGAQMGAVSLGDMLGKAFGGRTKARRVLVKDAHPLLLTEEADKLIDQEATTQEAIYAVENNGIVFLDEIDKIAQREGRSGADVSREGVQRDLLPLIEGTTVSTKHGPVKTDHILFIASGAFHVSKPSDLLPELQGRLPIRVELEALTRADFVRILTETEASLVKQSVALMGTEGVTLDISPDAVEAIADVAVEVNSTVENIGARRLQTVMERVLDELSFTAPDRSGETVSIDAAYVRERVADLAKNADLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCP1_MESAU
Sequence: MVNPTTSEVHPTMGVKIFSAGVAACLADIITFPLDTAKVRLQIQGEGQISSTIRYKGVLGTITTLAKTEGLPKLYSGLPAGIQRQISFASLRIGLYDTVQEYFSSGKETPPTLGNRISAGLMTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTESFSTLWKGTTPNLLRNVIINCVELVTYDLMKGALVNNQILADDVPCHLLSAFVAGFCTTFLASPADVVKTRFINSLPGQYPSVPSCAMTMLTKEGPTAFFKGFVPSFLRLASWNVIMFVCFEQLKKELSKSRQTVDCTT
What is the function of this protein?
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance.  Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane.  However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs.  Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP.  Regulates the production of reactive oxygen species/ROS by mitochondria.
What are the official names of this protein?
Mitochondrial brown fat uncoupling protein 1, UCP 1, Solute carrier family 25 member 7, Thermogenin.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FPG_BURM1
Sequence: MPELPEVEVTRRGIAPFVAGRRVERVDVRTAMLRWPVPAGLAEQLRAREVLAVERRGKYLLFEVDAGWFIVHLGMTGTLRVLPAGGVPVAAKHDHIDWIFDEFVLRFRDPRRFGAVLWHSREAGDVHAHPLLASLGVEPFSPAFDGALLHRRTRGRTVSVKQALLAGDIVVGVGNIYASESLFRAGIRPTTAAGKVSLPRYERLAEAVRATLADAIDRGGSTLRDFVGSNGESGYFQLDCFVYDRAGEPCRVCGTPIRQIVQGQRSTYFCPTCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.