PharMolix/UniProtQA huggingface dataset:
Protein: YAV5_XANEU
Sequence: MSDMKVNFSSKIIDSTPSEEEVATQQDSYTKSGLVAPSLDSQALKKAPRKRVIKENIAALHTSSLERVHQKKVLVQNLAQLQRGLAKINGRVELEELIDGFSVKELLIKRNPKIAEEYGEGNPLMIRSLRFSNPQEVTSKLGAEGKTPAKREVDTICNKSTLHDIVMTPASLVKKEVRMNLISEVPRAKDKQKYRGLPSVVYGQSSRRSESDYLTSRNGFGDVHSLKSNNAFNSDYEKICGSLSHAEKLGLIERNLTPFIRHDPDRISTDFVHSIEELAEHQMLLQSRKPASALRHNEYCTKLELWDAKAIAVGESRALAVATLIEFNLEMLSIAQEIDDDGHKSKMVADFIERQLSWLGPQTALDSKSTLERVSAVTIQEREFIANEISRSLRQGVSLCTYDKDEAGSHIREMSLLDFRVEEIIEGISIFISSKLLHVTNAGEA
What are the official names of this protein?
Uncharacterized 50 kDa avirulence protein in avrBs1 region.
Protein: SIA_ASPFU
Sequence: MQSMRFMILALLVQFLPAWAINDPAKSAAPYHDEFPLFRSANMASPDKLSTGIGFHSFRIPAVVRTTTGRILAFAEGRRHTNQDFGDINLVYKRTKTTANNGASPSDWEPLREVVGSGAGTWGNPTPVVDDDNTIYLFLSWNGATYSQNGKDVLPDGTVTKKIDSTWEGRRHLYLTESRDDGNTWSKPVDLTKELTPDGWAWDAVGPGNGIRLTTGELVIPAMGRNIIGRGAPGNRTWSVQRLSGAGAEGTIVQTPDGKLYRNDRPSQKGYRMVARGTLEGFGAFAPDAGLPDPACQGSVLRYNSDAPARTIFLNSASGTSRRAMRVRISYDADAKKFNYGRKLEDAKVSGAGHEGGYSSMTKTGDYKIGALVESDFFNDGTGKNSYRAIIWRRFNLSWILNGPNN
What is the function of this protein?
Sialidase is able to release sialic acid from a wide variety of natural substrates including bovine salivary mucin, colominic acid, bovine fetuin, a serum glycoprotein containing both alpha-2-6 and alpha-2-3-linkages in a ratio of about 3:2, and glycoproteins and glycolipids from thermally denatured human lung epithelial cells.  Does not show any trans-sialidase activity since it is able to remove terminal sialic acid residues but is unable to catalyze their transfer to the acceptor substrate.  2-keto-3-deoxynononic acid (KDN) is the preferred substrate and A. fumigatus can utilize KDN as a sole carbon source.
What are the official names of this protein?
Exo-alpha-sialidase, Alpha-neuraminidase, N-acylneuraminate glycohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 33 family.
Protein: RL11A_BACCR
Sequence: MAKKVIKMVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTADQAGLIIPVEITVFEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKRDKVREIAETKMPDLNAASVEAAMRMVEGAARSMGIVIED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11-1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: THII_SALHS
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALAQYREQLEGKTFCVRVKRRGKHEFSSIEVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKVDDGQMGVVLKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAIKAKIEAEEENFDFSILDKVVEEANNVDIREIAQQTQQEVVEVETVSGFGPNDVILDIRSVDEQDDKPLKVEGVDVVSLPFYKLSTKFGDLDQSKTWLLWCERGVMSRLQALYLREQGFANVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTC1_AGADC
Sequence: MAFLKKSLFLVLFLALVPLSICEAEKREEENEEKQEDDDESEKKRGVVTDLLNTAGGLLGNLVGSLSGGER
What is the function of this protein?
Neutral peptide with no antimicrobial activity (PubMed:15222751, PubMed:17128968).  Does not permeate bacterial membranes (PubMed:15222751).  May act in synergy with cationic peptides by enhancing their activity (Probable).  Has a moderate hemolytic activity (PubMed:15222751, PubMed:17128968).  It interacts with zwitterionic phospholipids (DMPC) without perturbing either the interface or inside of the bilayer, whereas it causes little perturbations at the interface peptide-anionic vesicles (DMPG) as well as in the bilayer alkyl chains (PubMed:15222751, PubMed:17128968).
What are the official names of this protein?
Plasticin-DA1, PTC-DA1, Dermaseptin PD-3-6, DRP-PD3-6, PD36.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Plasticin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: GLGC1_ALKEH
Sequence: MFLECNPRFVSRLTRDTLALIMAGGRGGRLSNLTDWRTKPAVPFGGKFRLIDFPLSNCINSGIRRIEVLTQYKAHSLIQHIQRGWGFLRGEFGEFVELVPAQQRMDKPLWYAGTADAVYQNIDIIKAHNPSYVLVLAGDHVYKMDYGGMIARHAESGAAMTVGCVEVPRKRASAFGVMSVNEERQVLAFNEKPKDPTPMPGNPDRALVSMGIYVFDRDYLFQLLREDAENFDSSRDFGKDVIPNAIANHKVQAYPFSDPVSGQQAYWRDVGTVDAFFQANMELIGEDPELNLYDEEWPIWTYQAQLPPAKFIQGRDGRHGTAINSMVSGGDIIHGAEVRDSLLFSQVVVQPGATVHEAVILPDVRVGEGCRIRKAVIDEGCRIPAGTVIGEDPAEDRRRFFVTPKDVVLVTAEMLGQEVAHVR
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase 1, ADP-glucose pyrophosphorylase 1, ADPGlc PPase 1, ADP-glucose synthase 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: RPOS_SALDU
Sequence: MSQNTLKVHDLNEDAEFDENGVEAFDEKALSEEEPSDNDLAEEELLSQGATQRVLDATQLYLGEIGYSPLLTAEEEVYFARRALRGDVASRRRMIESNLRLVVKIARRYGNRGLALLDLIEEGNLGLIRAVEKFDPERGFRFSTYATWWIRQTIERAIMNQTRTIRLPIHIVKELNVYLRTARELSHKLDHEPSAEEIAEQLDKPVDDVSRMLRLNERITSVDTPLGGDSEKALLDILADEKENGPEDTTQDDDMKQSIVKWLFELNAKQREVLARRFGLLGYEAATLEDVGREIGLTRERVRQIQVEGLRRLREILQTQGLNIEALFRE
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.
What are the official names of this protein?
RNA polymerase sigma factor RpoS, Sigma S, Sigma-38.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTXBC_STAAC
Sequence: MTKEQQLAERIIAAVGGMDNIDSVMNCMTRVRIKVLDENKVDDQELRHIDGVMGVIHDERIQVVVGPGTVNKVANHMAELSGVKLGDPIPHHHNDSEKMDYKSYAADKAKANKEAHKAKQKNGKLNKVLKSIANIFIPLIPAFIGAGLIGGIAAVLSNLMVAGYISGAWITQLITVFNVIKDGMLAYLAIFTGINAAKEFGATPGLGGVIGGTTLLTGIAGKNILMNVFTGEPLQPGQGGIIGVIFAVWILSIVEKRLHKIVPNAIDIIVTPTIALLIVGLLTIFIFMPLAGFVSDSLVSVVNGIISIGGVFSGFIIGASFLPLVMLGLHHIFTPIHIEMINQSGATYLLPIAAMAGAGQVGAALALWVRCKRNTTLRNTLKGALPVGFLGIGEPLIYGVTLPLGRPFLTACIGGGIGGAVIGGIGHIGAKAIGPSGVSLLPLISDNMYLGYIAGLLAAYAGGFVCTYLFGTTKAMRQTDLLGD
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in the uptake and phosphorylation of MurNAc-GlcNAc, the principle peptidoglycan turnover product of S. aureus, yielding cytoplasmic MurNAc 6P-GlcNAc.
What are the official names of this protein?
PTS system MurNAc-GlcNAc-specific EIIBC component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GMHA_HELPY
Sequence: MIDNLIKKEFLAHKEALEKSLEGLQEALKQSVHLLIETLENQGKILICGNGGSASDAQHFAAELTGRYKLERKGLSAISLNTDISALTAIANDYGYEEVFARQVEALGVKNDVLIGISTSGNSKNVLKAYEKAKDLEMKTLSLAGRDGGKMKPLSDMALIVPSDDTPRIQEMHILMIHILCDCIERHFAHKN
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_FRG3G
Sequence: MHGNSLQYVKLSEHASGLIRGSAGAAGYDLAAAHPVVVPSFGRALVKTDLAVKMPPGLYGRVAPRSGLALKKFIDVGAGVVDPDYRGNLGVILFNFGCDPFRVKRGDRIAQLVLERYESPPILEVDSLDSTDRGDAGYGSTGVGNWHSALWEGFSSGDLKESFV
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Putative deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: LPXC_GEOUR
Sequence: MAFQQTLKNKVAFSGIGLHSGKEITLTLRPADAGNGIVFHRIDTTPPVSIEARTENVVSTRLSTTIGKNGAAVSTIEHLMAALFSCGIDNAHVDINGPEVPIMDGSAAPFVEGIRNAGSKSLSKSRKYLVVKKPVTIRDGDKRITVLPSRYYRISFDMHFNHPVINRQFRTMKFDRESFADDFSPARTFGFLAEIEALMAHGLALGASLENAVGIDDNGIVNPEGLRFTDEFVRHKILDSIGDFALAGVHLVGHVKACKSGHELNHKFITELLSRSDCWSLMELTPPENKTASFPISLPEMAWLEAC
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: CH10_PORGI
Sequence: MNIKPLADRVLVKPAAAEEKTVSGIIIPDSAKEKPLKGEVIAVGNGTKDEEMVLKAGDTVLYGKYAGTEIELEGEKYIIMRQNDVLAII
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSB_BURO1
Sequence: MTHPPPFIAVIPARLASTRLPNKPLADLGGKPMVVRVAERAREAGAQQVLVASDAQSVLDAARDHGFEAVLTRADHPSGTDRLAEVAAAFGWRDDTVVVNVQGDEPLIDPVLVRDVASHLAAHPACAIATAAHPIHDAADVFNPNVVKVALDAQSVALYFSRAPIPWSRDAYQPHWPDVAAMPAPAFPVYRHIGLYAYRARFLRTYPSLAQAPIEQAEQLEQLRALWHGERIAVLITESAPEAGIDTPADLARVQALFQPGSK
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
Protein: LNT_PROMP
Sequence: MINTQNKKFNKYFVPCLGGIFGGIATSTHFWLLFMPLSLFILWSRSDKKLANFLWGFFFILVSHSWLYELHPLTWLGFSWISSLIISISILFGCSIIGGILVYLWGLLVKKILQKKEISNMNSLRLTIKVLLLSFAWGIGEFILSQTPLFWIGLGEGIVPGDLYLAGLARWIGASGLCVVQLTIGFWIYLIYEKWKRKYHFKKTFLFGLLILVILHFLGGLTNPIERNNDYPVALWQTNMPTREKTNFKNQFINDKLISAQKIALSNDAKLLITPEGTLNNNFNLNFKSKIRMLAGGFRNSKNGLRSSLLGYQIGDKTYSSFIDKHRLVPLGEKIPGFLNIFSRGLSAVGGIQPGSDSRFFKWKFTQPLAIAICYEITDGFKIRNAVKSGAELIISAANLDPYPRKLHYQFLSLARVRSIENKKDNIIISNTGPSGLISEEGKIIKLFDPNTEQNDVVNPNFSIEKTFYTTYGERPLFLLCLFLIGLNLYFGKFTN
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NU5C_PHYPA
Sequence: MEFIYQFVWIVPFFPFIASILIGVNLLFFPKSTKSLREIWAIFSILLLSIAMIFSFNILWQQINDNIIYRYLWSWIFDNKIDFKIGFLIDPLTSIMLVLITTVGVLVMIYSDSYMSYDQGYVRFFAYLSLFTASMLGLVLSPNLIQIYIFWELVGMCSYLLIGFWFTRPSAANACQKAFVTNRIGDFGLLLGILGFYWITGSFEFEILFKRFNDLVINHEVNLYFANFCALLLFLGPIAKSAQFPLHIWLPDAMEGPTPISALIHAATMVAAGIFLVARWFPLFQLLPFVMTIISWVGAITAFLGATIALAQTDLKKGLAYSTMSQLGYMMLALGIGSYQAGLFHLITHAYSKALLFLGSGSVIHSVESIVGYSPNKCQNMAFMGGLRKYMPITGITFLLGTFSLCGIPPFACFWSKDEIITDSWLYSSTLGSISLVTAGLTAFYMFRIYFLTFEGDLRVNLNKVAFTYPVSIWGELNLNKKNSNKNKFVLNKYDIFFETDQNENQTDNLSFFSDIKKLKYPKESDNKMLFPLLVLTLPTLFIGFLGAPFPEGQIGSDLLSQWLYPVFKSAEEITSGNWLEFGLNAINSLSVVFSGIFIAFILYGPFSLFPQNLEKNIEFSLEKNLNSFFSFIYNWSYFRGYIDVYYNIVFVKGTRLLAQSLSFFDEWIIDGFVNGFGILTFFEGESIKYLEGGRISFYLFGLIFGMIILLFIGFFGAMF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TRM1_METAC
Sequence: MICRTIVEGTTKISVPIPPPDVNFPPSAAPVFYNPEMELNRDINVAATAAFVKRLLSRKDLKREEVRYVDAFSASGIRGLRIAGEVGIHSTMNDWNPEAFELIKENIKINGLEEKAQATRKNANVLLHEQKFHIVDVDPFGTPAPYLDAAATAAQGMLSVTATDTAPLCGAHLNSGIRKYAAVPLNTEYHSEMGLRVLLGACARECAKHEKGMLPLLSHVTRHYVRSYLEVLPGTKHADRALKSMGFSIYCPKCGFRGPVYGLAVHIEKECPACGALTKIAGPLWLGPFREPKFCNEVLSELEAHPLNTKEKAKKIITFCRDELDIPMFYDQHVICKELGASATGIETLIEALKAGGFEASRTHFSGTSFRTDAPIAEIKKIIQALSG
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: ATPE_TRIV2
Sequence: MTLTVRVISPDKTVWDAEADEVILPSTTGQLGILSGHAPLLTALDTGVLRVRTSKSQNWQAIALLGGFAEVEEDEVTILVNGGERGDTINLEEARTAYSQAQTKLNQVPAGDRQAQIQANQAFKRARARFQAAGGLV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: ATPL_PARMW
Sequence: MDSITSAASVVAAGLAVGLAAIGPGIGQGTASGGAVEGIARQPEAEGKIRGTLLLSLAFMESLTIYGLVVALVLLFANPFAG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: RS12_META3
Sequence: MSGSKSPKGEFAGRKIVLKRKESRWHHYKYVNKALKLKEKSDPLGGAPMGRGIVVEKVGLEAKQPNSAIRKCVKVQLIKNGRVVTAFAPGNHAINFIDEHDEVVIEGIGGPSGQAKGDIPGVRFRVVMVGKNSMRELVRGRQEKVRR
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: VINC_MOUSE
Sequence: MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPNASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGASPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEIAALTSKLGDLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKAQMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGRLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
What is the function of this protein?
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion.  Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex.  May also play important roles in cell morphology and locomotion (By similarity).
What are the official names of this protein?
Vinculin, Metavinculin.
What is the protein family that this protein belongs to?
Belongs to the vinculin/alpha-catenin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, adherens junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Note=Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.
Protein: LDHA_PONAB
Sequence: MATLKDQLIHNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPSSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A, LDH muscle subunit, LDH-M.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTH_SHEPW
Sequence: MSHLVLTPGSLTLKQIREISRGKVTLELADSAIADINTSAGLVQQVLDEGRTVYGINTGFGLLANTKIAADDLQLLQRSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLIALVNAEVYPCVPEKGSVGASGDLAPLSHMCLPLLAEGEMSYKGQLITAAEGLEIAGLKPLELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDSRIHAARGQKGQIDSAAVFRHLLGDESEISLDHVNCEKVQDPYSLRCQPQVLGACLTQIRHAAEVLGTEANGVTDNPLVFQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYAHPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRRPLQPAVAVAKAKAELRELVTYYDKDRFFGPDIEAATDLLITASYNAYLPADILPSW
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBA5_CHICK
Sequence: MAERVELLERRVRELERELELARGGRASARARIETMSPEVTDSNPYSRLMALKRMGIVKDYEKIRTFTVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVQFEVHNYNITTLDNFEHFMDRISNGALEEGKPVDLVLSCVDNFEARMAINTACNELGQIWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKYLLNFGTVSYYLGYNAMQDFFPTMAMKPNPQCSDQNCRKQQENYKIKEAAQPKQEEIHQEEEIVHEDNDWGIELVSETTEDELKAASGPVPDLPVGITVAYTIPNKEENLTAEETVAESEESLEDLMAKMRNL
What is the function of this protein?
E1-like enzyme which specifically catalyzes the first step in ufmylation.  Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP.  Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer.  Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding.  Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism.  Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme 5, Ubiquitin-activating enzyme 5, UFM1-activating enzyme, Ubiquitin activating enzyme-like protein.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Golgi apparatus.
Protein: COAA_RHOP5
Sequence: MDVRADQHQYNPYRVFSRDQWAKLRDDAPMTLDAQEISALRSMHDRLDLQEVEEIYLPLSRLLSIYVASMQQLYVAQRRFLGIVDRKMPYIIGVAGSVAVGKSTTARVLQALLARWSPRPKVDLITTDGFLYPNAVLERQGIMQKKGFPESYDLPKLLAFLSDIKAGRRRVRAPVYSHLTYDIVPNSHITVDRPDILIVEGVNVLQTGKLPRDGKAVPVVSDFFDFSVYIDAEEPVLREWYVSRFLALRDTAFHDPRSYFHRYAPLSDEEATATALAIWERTNLANLEDNILPTRPRATLILKKGADHVVETVALRRL
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARME_YEAST
Sequence: MDENEFDNQRENKAVARVIISFLKYEEYALKEIYNLRVKKWASISDRQKDMVPNYTKYLANLKAAIIENGKFFRSVAEYALQSISFEPGEIVQPNDLDMSKTCSLLTQVYREWSAEAISERNCLNSRLVPFLKTLSPPKADILIPGCGTGRLLVDLSRMGYNCEGNEFSYHMLLVSQYMLNAGLLQNQIIIYPFIHCFSHWKKIEDQLSPIKVPDIEAWSSNKGMGSMSICAGSFVDCYGRNQGTKISSHYTFSRRMQLSRAKAENSKDVVVTNFFIDTGSNILDYLDTIGHVLKPGGIWCNFGPLLYHFENDHGVETTYEVNPYSGFQDKINDYTPLMGLELSSDDIISIATNHLDFELIRRESGILCGYGRYAGPESCAMPGYMCHYWILKSNPTNES
What is the function of this protein?
N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine.  Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
What are the official names of this protein?
Carnosine N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the carnosine N-methyltransferase family.
Protein: U24_HHV7J
Sequence: MTHETPPPSYNDVMLQMFHDHSVFLHQENLSPRTINSTSSSEIKNVRRRGTFIILACLIISVILCLILILHIFNVRYGGTKP
What is the function of this protein?
Down-regulates of the TCR/CD3E complex and the transferrin receptor TFRC in host T-cells by blocking them from recycling back to the cell surface.
What are the official names of this protein?
U24 protein.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.