PharMolix/UniProtQA huggingface dataset:
Protein: RUVC_ACIET
Sequence: MRILGIDPGLQTTGFGVVDVDGHRLRYVASGTIRTTGRATGLALGDLPGRLKVLFDGVSEVAARYQPSTAAVEIIFVNVNPQSTLLLGQARGAALTALVNANLPVAEYTALQMKKAVVGHGRAAKSQVQEMVRRLLELPGLPGTDAADALGLAITHAHAGAAMARVGEVAQLTRRQHAMYKAGRSY
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: CBP6_SCHPO
Sequence: MSLNQKITKAVALWPKDELRPWLSFPKTLDTSIRARLQKMPPQQANKQLNALNNLLDNVYWNKYIPKQVVLKPQFKPSYYESLTQIRRKEEKAPLWKRLFKRK
What is the function of this protein?
Involved in processing of the 5' terminus and the intervening sequences of cytochrome b pre-mRNA.
What are the official names of this protein?
Cytochrome B pre-mRNA-processing protein 6.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YNAB_BACSU
Sequence: MEDATFHFKDPASPQEISDIEQKLGVTFPNDYKEFLLQHNGMEMFDGIEILSLEGIIEYNEVQDFPEGYVLIGYHFDGRYVIDTNKSKNGLGYMLYLDSIDDIEDAINLDSNFEIWFDMLVSLNGTKYWEVNPNLQEYYKLVSE
What are the official names of this protein?
Uncharacterized protein YnaB.
Protein: MNMA_WOLTR
Sequence: MLKEFEIEPLLKDKVPHQTKAVVAMSGGVDSSVAAVLLHRLGYQVIGVTLQLYGADGNSNTRKKGVCCAGQDIYDAKRVAEGTGFPHYILNYEEIFKKEVIESFAQTYIQGKTPIPCIKCNQTVKFRDLLQVTRNLGADVLITGHYVRRLEKNGEVKLCRGIDKSKDQSYFLFATTKEQLKLLRFPLGGFYKCNVRKLARYFSLPISEKPDSQDICFVSENYSKTIAKLAPQSIQKGKIVDVNGKVLGEHNGIVNFTVGQRKGLGIAYSEPLYVVRINTKNNEIVVGPVNALMQRKILVKELNWLEQPKKGMEVTVKLRSLHSGSLAKIYPAKEQNKAYVILNDDYFSISPGQACVAYKDEQVIGGGWICS
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOD_STRPF
Sequence: MSIHISAKKGDIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTGTYKGHRVSVMGTGMGMPSISIYARELIVDYGVKTLIRVGTAGAIDPEVHVRELVLAQAAATNSNIIRNDFPEFDFPQIADFGLLDKAYHIAREMGVTTHVGNVLSSDVFYTNMPERNMVLGKLGVKAIEMEAAALYYLAAQHHVKALGIMTISDNLNDPTEDTTAEERQTTFTDMMKIGLETLIAND
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: BCHB_RHOPB
Sequence: MQLTVWTYEGPPHVGAMRVATGMEGLHYVLHAPQGDTYADLLFTMIERRDRRPPVTYTTFAARDLGGDTAELFKTAVQNAYERFRPQAMIVGASCTGSLIQDDPGGLAKGMGLPVPVIAIDLPAYQRKENWGAAETFYQLVRALAGPSAPPPGSKRPERAPGVRPKCNILGPTALGFRHRDDVIEITALLGKLGIDVNVTAPMGATPADLTRLGEADFNVVLYPEIASQAASWLHRIFHQPFTKTIPIGVSATREFIEEVAALAGVDAAPVLKANSSRLTWFSHSVDSTYLTGKRVFIFGDATHVVAAARIASDEIGFKVVGIGTYSREFGREIREAAKLYDVEPLITDDYLEVEAHIAELQVELVLGTQMERHISKRLGVPCAVISAPVHIQDYPARYAPQMGFEGANVIFDTWVHPLMMGLEEHLLAMFKDDFEFKDGAVPSHLGVGHSAPAVQTASSEPQPSAIETPSAAATETAAVWAADAEKELRKIPFFVRGKARRNTERFANENGVATITVETLYDAKAHFSR
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: PFPAN_ENTHI
Sequence: MKAIVFVLIFAVAFAVTLRQGPIVCNLCTGLINTLENLLTTKGADKVKDYIDSLCNKASGFIATLCTKVLDFGVDKLIQLIEDKVDANAICAKIHAC
What is the function of this protein?
Forms pores in the cell membrane of host cells (PubMed:8515772).  Implicated in the cytolytic activity of the parasite (PubMed:8515772).  Pore forming activity is lower compared to the activity of ameobapore A from the pathogenic strain HM-1:IMSS (PubMed:8515772).
What are the official names of this protein?
Non-pathogenic pore-forming peptide amoebapore A, APNP.
Protein: RIMP_LIMRD
Sequence: MSSVVETVTDLVTPILQDHDFYLYDLEFVKEGKSWYLRVYINKDGGITLEDCALVSDELSEALDNVEPDPIPQAYFLEVSSPGAERPLKKEEDYQRAIDHYIHISLYQQINGQKVYEGTLTQLSDKEITLDYLDKTRHRQITIDRQKIAQARLAIKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_LEPIC
Sequence: MKENETLKQIVLKTLEESVNSLISSFPEVEKEAFKIKIEYSRDEKFGDYSTSFALENSKLLKRNPIQVSKELVEILQKRTDLFEKVDFTPPGFVNFRISTSFLLNYIETSVLSGNYFPKVDLPLKINLEFVSANPTGPLNIVSARAAANGDTMASLLKAIGHNVDKEFYINDYGNQVFLLGVSTLVRIRELKGEEGTQQETTDDTPIEIILEKNILPAEGYRGEYIKDIASSLLKDPKKNVTIENLLKQKKYKELAELCAVWTIENNLIWQRKDLDAFGVEFDCYFSERTLHEADKVLSVMKDLEKSGKIFQEDGKKVFRSTEYGDDKDRVVVRDDGRPTYLLADIAYHKDKIERGYDKIYDIWGPDHHGYISRLSGAVQSLGYKKENFKVIISQQVNLLESGQKVKMSKRAGSFQTMSDLIGFLGKHGKDVGRYFFVMRSLDAPLDFDLDLAKDESDKNPVFYLQYAHARICSIFKEVGDQTSKEAAAILEMSEERKRLLFWIARFPEEIFDSANAMEPHRVTNYLQSFAKAFTSFYLAKDNRLKDASKEVRLGLARICLAAKNVLAEGLKLIGVSAPERMEKEN
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPR_MOUSE
Sequence: MMCQKFYVVLLHWEFLYVIAALNLAYPISPWKFKLFCGPPNTTDDSFLSPAGAPNNASALKGASEAIVEAKFNSSGIYVPELSKTVFHCCFGNEQGQNCSALTDNTEGKTLASVVKASVFRQLGVNWDIECWMKGDLTLFICHMEPLPKNPFKNYDSKVHLLYDLPEVIDDSPLPPLKDSFQTVQCNCSLRGCECHVPVPRAKLNYALLMYLEITSAGVSFQSPLMSLQPMLVVKPDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSSPQVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVSDRVSKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHPTSEPKNCVLQRDGFYECVFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITVNTGLLKVSWEKPVFPENNLQFQIRYGLSGKEIQWKTHEVFDAKSKSASLLVSDLCAVYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFWRKMDGDVTKKERNVTLLWKPLTKNDSLCSVRRYVVKHRTAHNGTWSEDVGNRTNLTFLWTEPAHTVTVLAVNSLGASLVNFNLTFSWPMSKVSAVESLSAYPLSSSCVILSWTLSPDDYSLLYLVIEWKILNEDDGMKWLRIPSNVKKFYIHDNFIPIEKYQFSLYPVFMEGVGKPKIINGFTKDAIDKQQNDAGLYVIVPIIISSCVLLLGTLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKPETFEHLFTKHAESVIFGPLLLEPEPISEEISVDTAWKNKDEMVPAAMVSLLLTTPDPESSSICISDQCNSANFSGSQSTQVTCEDECQRQPSVKYATLVSNDKLVETDEEQGFIHSPVSNCISSNHSPLRQSFSSSSWETEAQTFFLLSDQQPTMISPQLSFSGLDELLELEGSFPEENHREKSVCYLGVTSVNRRESGVLLTGEAGILCTFPAQCLFSDIRILQERCSHFVENNLSLGTSGENFVPYMPQFQTCSTHSHKIMENKMCDLTV
What is the function of this protein?
Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.
What are the official names of this protein?
Leptin receptor, LEP-R, B219, OB receptor, OB-R.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane. SUBCELLULAR LOCATION: [Isoform E]: Secreted.
Protein: MKAR_BOTFB
Sequence: MVLDTILPKAVLTGLAGIGAFIVAGKVISYIQLLLSLFVLSGKNLRTYGKKGTWAVVTGASDGLGKEYAIQLAQKGFNIVLVSRTESKLQTLASEIQTKYAGSNIQTKILAMDFAANRDEDYAKLKALVDGLDVGILVNNVGQSHSIPVPFIQTPKEEMRDIITINCMGTLRVTQIVAPGMVQRKRGLILTMGSFGGWLPTPLLATYSGSKAFLQQWSTSLGGELKGTGVDVELVLSYLVTTAMSKIRRTSMFIPNPRTFVKTTLAKVGRSGGAQKMAYTSTPFWGHALMQWWLENTLGVGGSFVVDQNKGMHQSIRTRALKKAERDAKKA
What is the function of this protein?
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate.  Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation.  VLCFAs serve as precursors for ceramide and sphingolipids.
What are the official names of this protein?
Very-long-chain 3-oxoacyl-CoA reductase, 3-ketoacyl-CoA reductase, 3-ketoreductase, KAR, Microsomal beta-keto-reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RL28_MESM1
Sequence: MARRDDLTNKGPMSGNKRSHALNATKRKFNLNLQKILVTLENGSKVKIKVSAKTAKTLKKQGFVA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: TDH_MOUSE
Sequence: MLFLGMLKQVVNGTAQSKASSCRKLVLPLKFLGTSQHRIPADANFHSTSISEAEPPRVLITGGLGQLGVGLANLLRKRFGKDNVILSDIRKPPAHVFHSGPFVYANILDYKSLREIVVNHRISWLFHYSALLSAVGEANVSLARDVNITGLHNVLDVAAEYNVRLFVPSTIGAFGPTSPRNPAPDLCIQRPRTIYGVSKVHTELMGEYYYYRYGLDFRCLRYPGIISADSQPGGGTTDYAVQIFHAAAKNGTFECNLEAGTRLPMMYISDCLRATLEVMEAPAERLSMRTYNISAMSFTPEELAQALRKHAPDFQITYCVDPLRQAIAESWPMILDDSNARKDWGWKHDFDLPELVATMLNFHGVSTRVAQVN
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.
What are the official names of this protein?
L-threonine 3-dehydrogenase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RIBL_METBF
Sequence: MTRILATGTFDLLHPGHIYFLTQARALGDELFVIVARDSNVTHKPKPIVSEEQRLEMVNALGIVDKALLGSEKDMFEPLKHIRPDIIALGYDQRFNAENLEEELAKRGLPANVVRIPLSKECPLCSTGAIIKEVLKRYG
What is the function of this protein?
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
What are the official names of this protein?
FAD synthase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the archaeal FAD synthase family.
Protein: ACM4_XENLA
Sequence: MENDTWENESSASNHSIDETIVEIPGKYQTMEMIFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYSLYIIKGYWPLGPIVCDLWLALDYVVSNASVMNLLIISLERXFCVTKPLTYPARRTTKMAGLMIAAAWLLSFELWAPAILFWQFIVGQRTVPSGECYIQFLSNPAVTFGTAIAAFYLPVVIMTILYIHISLASRSRVRRHCPETRQEKKKPISSMKSLLIKQTKNIPKQDAGDKVVEKKNGVSNGKIEKSMTNLQTAEEKETSNESSSASLSHNPPEKQPLSEASSGVVLAPTQSMPPLPAKANTASKWSKIKIVTKQTGNECVTAIEIVPECAIPLPEQANNRPVNVARKFASIARNQVRKKRQMAAREKKVTRTIFAILLAFIITWTPYNVMVLINTFCQTCIPETIWYIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYKSIGTAR
What is the function of this protein?
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.  Primary transducing effect is inhibition of adenylate cyclase.
What are the official names of this protein?
Muscarinic acetylcholine receptor M4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: RL11_SALEP
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSIEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKISRAQLQEIAQTKAADMTGADIEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ENOPH_ASHGO
Sequence: MEEDYGVFILDVEGTVCPIAFVREQLFPYFLDKVEELINNADETERDLLADMQSRHGGAAAASLLRQLVAEDVKDPALKALQGRVWERGYASGEITAPVYADAVRFIQRNAGRVYIYSSGSVQAQRLLFGHVSNPSGDGVLDLTGHLAGFFDIPAAGRKTEAKSYERILAAIGLERQPGAAIFVSDSVAELDAASASGLSVRLAVRPGNERVSGARYTTLTDFEGL
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NADK_PASMU
Sequence: MKHPNTIDIKALQSSFQIIGLLGKPRHDVTLQMHKNLFQWLLEKGYQVLVERPIGEQLGLSENYLASVDEIGQQAQLAIVIGGDGNVLGRARTLAKYDIALIGINRGNLGFLTDIDPKNAYSQLQACLEDGDCFVEERFILEASVERNGKIIARGNAVNEAVVHPAKIAHMIDFHVYINDKFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPQLNAIALVPMFPHTLSSRPLVIDGDSKISIRFAEYNTSQLEVGCDSQVALEFSPDDIVHIQKSPDKLRLLHLKNYNYYKVLSSKLGWLRNSV
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECE2_MOUSE
Sequence: MNVALHELGGGGSMVEYKRAKLRDEESPEITVEGRATRDSLEVGFQKRTRQLFGSHTQLELVLAGLILVLAALLLGCLVALWVHRDPAHSTCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW
What is the function of this protein?
Converts big endothelin-1 to endothelin-1.  Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides (By similarity).  May play a role in amyloid-beta processing (PubMed:12464614).
What are the official names of this protein?
Endothelin-converting enzyme 2, ECE-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M13 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle membrane.
Protein: RR14_PHATC
Sequence: MAKKSMIEREKKRIKLTKKYALKRATLLKKYQTEESFNLKLELHSKIQKLPRNSAKTRIRNRCWKTGRPRGVFRDFGLSRHVFREMAHQCLLPGVTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HEM1_MARMS
Sequence: MPLITVGINHKTAPVSIRERVAFAPEKMIDALSSLISENKANEAVIVSTCNRTELYCSVEDLSKVDDVIAWLGKYHGIALPELQQYCYTHADDDSVRHVMRVASGLDSLILGEPQILGQVKSAYAVSQEGSCIGPELESLFQRTFSVAKRVRTDTAIGENPVSIAFAAVSLAQRIFADIRNSTALLIGAGQTIELVARHLKENGIKHIIVANRTLARAQILADELNAEAIMLGDIGDYLSQADIVISSTASQLPIIGKGMVERATSQRRHSPMLLIDIAVPRDIEPEVEEVNDAYLYTVDDLHSVIEENVRARQDAAKAAEQMIEEGVDSYRRVVESRKVSDLIVTFRQSAEAIKNTELEKALKGLEMGQSPEQVLNKLAHGLMNKLIHAPTRYLRDAGADADQDALIIASNVLGIYEEKDN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RL33_GRAFK
Sequence: MAKKGNRVQVILECTEHKTSGQPGTSRYITTKNKKNTPDRIELKKFNPILKKMTVHKEIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PYRH_CHLAB
Sequence: MSKRITRVLFKISGESLSTDSGNRIDEVRLSRLVAELRAVRNCDIETALVIGGGNILRGLAQQKELQINRVSADQMGMLATLINGMAVADALKADDIPCLLTSTLSCPQLADLYTPQKSEEALNQGKIVICTTGTGSPYLTTDTGAALRACELKVDILLKATMHVDGVYNKDPRSFSDAVKYDRISFKDFLAQGLGVMDASAVSLCMDSNIPIRVFSFVKHSLEQAIFDENIGTLIGEEATHVHSS
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIMP2_HUMAN
Sequence: MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK
What is the function of this protein?
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329).  Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation.  Blocks MDM2-mediated ubiquitination and degradation of p53/TP53.  Functions as a proapoptotic factor.
What are the official names of this protein?
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38, Protein JTV-1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Protein: DAPH_STAEQ
Sequence: MVQHLSAQEIIQYISDAKKSTPLKVYVNGHFENVTFPESFKVFGSEHSKVIFCEADEWKQFYQKNHSLITELEIEMDRRNSAIPLKDLTNTNARIEPGAFIREQAIIEDGAVVMMGATINIGAIVGEGTMIDMNATLGGRATTGKNVHVGAGAVLAGVIEPPSASPVVIEDNVLIGANAVILEGVRVGAGAIVAAGAIVTQDVPAGAVVAGTPAKVIKQTSEVQDSKREIVSALRKLNNE
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: SGO2_MOUSE
Sequence: MEYPGIKVDTVTSGIQRRVKGRIAKTNLNVSLASKIKAKILNNSSIFKISLKHNNRALARALSKEKENSRRITTEKMQLQKEVEKLNFENTFLRLKLNTLNKKLVEIESHVSNDLLTAIEISSLSEFHQGSFLLSATKKQRNSKQCKPAHLPYARVLLTSENDDDDGADDKWQTKCNNRTISKTSPDSTSSVSRQPSSLHQCNLKAFPPKEDNQKTCGSGHLEHTSSVDILPNESHSDQSPKSSLSEMKTAPSPSLRREKLSHGNVTMRKKCVSSTPDILYVTDLDHQPTSSPGSNWNNEIHGHTNETSNNTQRNAECFLDLPSESSSEPDAKRMELVQKNTDSFHFQKTVYDAADMELTATDIGKIVAVSKSKKNQNKKKADCRKETFRKVKGASSDKKRESSKRECKDGSEVGAEEEADAARAERGAGVLDGRGDSEEPNCISSTEQPSQVNTQKKRTLQNSSDQENIQNTKRRQTYTTDEQEETNPFSRHSVKFLQDGKFDLCQKTLHHNLSKPSRQTFVIRKSEKDNLFPNQEDKDTISENLEVTNEFHIDDLSIEANENVCDHETQTMLDLKKSVSAQQNQTKINKTKQKINRRTKIISVMSQVYEDNDKDIHVLEKDNFPFHTQANKETTSGNLESSKEFESPLLFTRDNGSLRDCKTQNVLDLHKQIPDLYPDRNESQISKIPRQKVNRKTEVISGVKCFSNDQGVHCSEKDKSLLLQKDKDFPGTLKDLSEFDTPAFCNKDSAKSCDYKSEMLLGLKKHDPNMQPACQDDSKAGKKLRQKVNRKTEIISKITQIHENDRGSTHDSLNKKLCQKVNISKIISQMNQIYETINEDGNGFKSSIKDCEDIKSCDFGEINSNKKENYDPIQDPCTLVKKTKRKGSCKAGSSLAGAKNRCGLQLTDSSQVQSVPLDSGLRHHPNEADSGPGEQTNLPKMQKQSAGRSLGDAFSVSLGKEGSRPAKAVSKMTPKSKKRKLPLGCSPETHGTVEITPNTDLAKAVDSQQTEKENYLEKEKIAKRKPDFCTKVLKPLSETCSSNIKNSSLDSMCKSSLPLSISSRKTLMLEESSSLESTCIFQVGDAAHEKITTGTRNPHHRTQKSTPGSRTSLVLVDTSSVSDTNPANPENESEGQSSHPMRRKRQCVPLNLTEPSLRSKMRR
What is the function of this protein?
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I.  Has a crucial role in protecting REC8 at centromeres from cleavage by separase.  During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres.  Is thus essential for an accurate gametogenesis.  May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation.  Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.  Involved in centromeric enrichment of AUKRB in prometaphase.
What are the official names of this protein?
Shugoshin 2, Shugoshin-2, Shugoshin-like 2.
What is the protein family that this protein belongs to?
Belongs to the shugoshin family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Centromeric localization requires the presence of BUB1 and AUKRB (By similarity). During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (PubMed:17205076) (PubMed:18084284). SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (PubMed:17205076). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (PubMed:17205076).
Protein: NMD2_SCHPO
Sequence: MSREEQIKKLNQYLDNRELAFRAKDGDKNIFHTESQLDSSLKKNTAFMKRCKSSLTSENYDSFIKEIKTLSLKKFIPEITAAIVEGMMKCKATKDILSSVKIVWALNLRFSTAFTGPMLANLYCALYPNPGYSLCHESYFELKQNENEVSEKDRSSHLLKVRPLLRFLIEFWLNGVVGTPEDFVSYLPSTDSNDKKFRKPWFEEQNLKKPLVVLLFNDLMDTRFGFLLLPVLTSLVRTFSCELFTTEDFEDKETLELVNRLNPVVWRTYLRKSLNSYVDKLEVYCQKRKSLFEELNKQYQEQSIIRADPNNEKFQRLANFSKSIESEFSSYASLSEVLNRKASEDLLELNFMEKASSGTNSVFNASGERSESANVETAQVWDDREQYFFYEVFPNFNEGSIAEMKSSIYESSQEGIRSSSENNKKEDDLKDSTGDLNTTQVSSRVDNFLLKLPSMVSLELTNEMALEFYDLNTKASRNRLIKALCTIPRTSSFLVPYYVRLARILSQLSSEFSTSLVDHARHSFKRMIHRKAKHEYDTRLLIVRYISELTKFQLMPFHMVFECYKLCINEFTPFDLEVLALLLESCGRFLLRYPETKLQMQSFLEAIQKKKLASALASQDQLVLENALHFVNPPKRGIIVSKKKSLKEEFLYDLIQIRLKDDNVFPTLLLLRKFDWKDDYQILYNTIMEVWNIKYNSLNALARLLSALYKFHPEFCIHVIDDTLESLFSAVNNSDHVEKQKRLAQARFISELCVIHMLDVRAITNFLFHLLPLEKFESFLTMKASTLTNINNDMFRLRLIVVVLQTCGPSIIRSKTKKTMLTYLLAYQCYFLIQPEMPLDMLYEFEDVIGYVRPSMKVYMHYEEARNALTERLQAISDDWEEDDTRPVFQGANDGDISSNEESVYLPEDISDESETDEESSGLEESDLLDSEDEDIDNEMQLSRELDEEFERLTNESLLTRMHEKNPGFDVPLPLRASSLGSPYVTRNEESASESSHVMFTLLTKRGNKQRSQYLEIPSHSSLVRSTKNQQTEEIMERKRVKEMVLNFE
What is the function of this protein?
Involved in nonsense-mediated decay of mRNAs containing premature stop codons.  It interacts, via its C-terminus, with NAM7/UPF1.  Could be involved in determining the efficiency of translational termination or reinitiation or factors involved in the initial assembly of an initiation- and termination-competent mRNP.
What are the official names of this protein?
Nonsense-mediated mRNA decay protein 2, Up-frameshift suppressor 2.
What are the subcellular locations of this protein?
Cytoplasm.