PharMolix/UniProtQA huggingface dataset:
Protein: COX2_HYLLA
Sequence: MAHATQVGLQDATSPIMEELISFHDHALMIIFLISFLVLYALFLTLTTKLTNTNITDAQEMETVWTILPAIILVLIALPSLRILYLTDEINDPSFTIKAIGHQWYWAYEYTDYGGLIFNSYMLPPLFLEPGDLRLLEVDNRVVLPIEAPVRMMITSQDVLHSWTVPSLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SIPL4_ORYSJ
Sequence: MGTSSPEMAAALLLVMAALAGVAAGGDIVHQDDEAPKIPGCSNDFVLVKVQTWVNNREDGEFVGVGARFGPTIESKEKHANRTGLLLADPIDCCDPPTQKVAGDVLLVQRGNCKFTKKAKNAEAAGASAIIIINHVHELYKMVCDRNETDLDINIPAVLLPKDAGNDLQKLLTRGKVSVQLYSPDRPLVDTAEVFLWLMAVGTILCASYWSAWSAREAVIEQEKLLKDGHESSLNLEAGGSSGMVDINMTSAILFVVIASCFLIMLYKLMSHWFVELLVVIFCIGGVEGLQTCLVALLSRWFKPAAESFVKVPFFGAVSYLTIAVCPFCIVFAVIWAVYRRMTYAWIGQDILGIALIVTVIQIVRIPNLKVGSVLLSCSFLYDIFWVFISKMWFHESVMIVVARGDKTDEDGVPMLLKIPRMFDPWGGFSIIGFGDILLPGLLIAFALRYDWAAKKTLQSGYFLWSMVAYGSGLMITYVALNLMDGHGQPALLYIVPFTLGTFIALGRKRGELRNLWTRGQPERVCTHMHMQPSPKDTNCDAVSS
What is the function of this protein?
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.
What are the official names of this protein?
Signal peptide peptidase-like 4, OsSPPL4.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22B family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein.
Protein: GRPE_SHESA
Sequence: MSNESIKAEQDLIQEGVESEVSTEEASLIDELTQANFRIEELEQLLADALAKVEEQKDSVIRAAAEVDNIRRRAAMDVEKANKFALEKFANELLPVLDNMERALQGTNPQDETTKALFEGVELTQKSFLTAVAKFGVKPIDPQGQAFNPDQHQAIGMQPSAEYPANTVMLVMQKGYELNSRLLRPAMVMVSQGGPSQESASINIEA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_DEIGD
Sequence: MNRTATRVLSSIEEVREALAGPGRVGLVPTMGYLHEGHAALIRRARAECDTVVLSVFVNPRQFGVNEDLSRYPRDLNRDLAVAEAAGADLLFHPDVATMYPAGYATTVAVGGVSEPLEGSSRPGHFDGVATVVLKLLNIVQPERAYFGEKDWQQLAVVRRMVRDLNVPVQIVGVPTVREPSGLALSSRNSYLTPEQQARAAILSRALQAVQAAAAAGERDTARLRQAGLAVLAEEPEIELDYLAVVDGDMREKAHVENDPLTRVLVAARLFGVRLIDNVPLSPAERRLSERESRNT
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEF_HV192
Sequence: MGNKWSKCSTVGRPAIRERMRRAPAAEGVGPASQDSDKYGALTSSSTPANNADCAWLEAQQEEEEVGFPVRPQVPLRPMTYKAVVDLSFFLEEKGGLEGLIYSKKRQDILDLWVYNTQGYFPDWQNYTPGPGVRFPLTFGWCFKLVPVDPREVEEANTGENNSLLHPMSLHGMEDSHREVLQWKFDSLLARRHMARELHPEYYKDC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: GLGC_LACP3
Sequence: MSTEMLGMILAGGQGTRLGKLTKTTAKPSVPFGGRYRIIDFTLSNLANSGVNTAGVITQYQPLELNRHIQNGASWGLNERGAGVTILQPYASSEGEKFFEGTAHAIYQNIAYIDSYNPQYLLILSGDHIYKMDYQAMLDYHKAKKASLTVAVMPVEKEEAKRFGIMNTDDTDRIIEFEEKPAKPKSNLASMGIYIFNWPTLKQYLTESYATDGAMEDFGHDVIPAYLTHNEASYAYAFRGYWKDVGTIQSLWEANMEFLNPNNPLNIGNRNWRIFSQNEALPPMFLTKTAKVAGSMIVDGCYVAGSIQHSILSQNVKIGEGSVIKDSMIMPNAVIGKNVTVDHAIVGENAIIGDNGKVVGKPNEISVVGYGEVLGRTEKE
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: APRP_ENTH1
Sequence: MLGSKSIIAVVAIASAIVTGVVVIVVVVTLSVVLTRSSVKDTNSIYVPDVITNDPQMTNEMDTLEVISSSKFSGTKPKEWTMKYTKYPYWRCGLTFTNEEKQNIVNENKEYMNSLLQLINNGSLGRMPEKYGGDKQFEANGVNWEADRLEVRYGLFGRVFGQRAVAWAFPGEIVTIKFPKGMSYKGIQVGIGKCNHNPSDQWLNVNNWSNDRMPIDSIGFDLGLNTTQPYIINDTFKIGSPFGGMIYLRSDTTFTNSFYVTFSNVGRAPIINYNITTNEEWNSVLRNAPGNVAEIRTPGNRLVLTSRNIRSLEDAQYISDFWLKAISISNYAVTLENIPITLNFDQRVDAGAAVAYVGRWFTQNPSDWAAACVGKDGLINYGNWGPLHEMNHHMQGTYLKGGNWGISNPGEETNNVMTSINYILYTNIAGHRNQGLSGWNYVSDGYSTIYKILKGENDQPHLRSYVNMAHAFGTDTLIALVKSYYGLWYENNFESKYSIKRDSTSAFCLLAALVTKRDTRYLCSLFKYDIQSNVSEAIKNMNYPTYYPFFNLYAMSYNGNYYGRPYKIPYGRTRLNFTATTAIDPKATSVSYTIKSGLTKGKLERVEDNVYDYTPFFGIEENDTFVLNIDCVVNGEKVHIEQEGTFELDPHQVEYEVYKDVQTRDMAQALNIIQNKTANDTGRASFFGIGTYNDGSMQSMLVEKGKLIVPKSGYYTLFMKADDLGRLLLNITGEYEQLLDVKTYLGGYSKTLNGSYATVKLEKDVGYPFILYNLNTGGQGFIRIGYCYHGTEESSVDVSKCSVSDIGSSMVLNEKVKTGAKEPEFQIPPIKYSRPTRFLTNAYRTIPKCLNGDDACSIKCLSLPLKHDDSSKCSNMFDDNYSTMYHSRWTGQGTTFPVNYTFEFSENVTFNNLYVHHRRPEDSWGYFEMFVKSPETGEMELLEKYKHPKSTTTELNFQKLVTTDRVQFIVYNNSNGGNYVNVVELSFNIKETFKNYTNSFGPKIKSTGFKKVTTPGASGGYLAVNEKEGEGSLCFKAKVTKFGLYGYRKTTSGKFRVTIDSQPGEVTSQSYFSDSERTLFYAHTFDETEANKVHNICMEVVEGTVNLDIIGSS
What are the official names of this protein?
Antigenic protein P1, Pathogenic protein 1.
Protein: GD_EHV1A
Sequence: MSTFKLMMDGRLVFAMAIAILSVVLSCGTCEKAKRAVRGRQDRPKEFPPPRYNYTILTRYNATALASPFINDQVKNVDLRIVTATRPCEMIALIAKTNIDSILKELAAAQKTYSARLTWFKIMPTCATPIHDVSYMKCNPKLSFAMCDERSDILWQASLITMAAETDDELGLVLAAPAHSASGLYRRVIEIDGRQIYTDFSVTIPSERCPIAFEQNFGNPDRCKTPEQYSRGEVFTRRFLGEFNFPQGEHMTWLKFWFVYDGGNLPVQFYEAQAFARPVPPDNHPGFDSVESEITQNKTDPKPGQADPKPNQPFKWPSIKHLAPRLDEVDEVIEPVTKPPKTSKSNSTFVGISVGLGIAGLVLVGVILYVCLRRKKELKKSAQNGLTRLRSTFKDVKYTQLP
What is the function of this protein?
Envelope glycoprotein that binds to host cell entry receptors.  May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
What are the official names of this protein?
Envelope glycoprotein D, gD, Glycoprotein 17/18.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein D family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs.
Protein: CALM2_ORYSJ
Sequence: MADQLTDEQIAEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMAKKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin-2, CaM-2.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: TUSA_ECO24
Sequence: MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPGFCTFMEHELVAKETDGLPYRYLIRKGG
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KI16B_MOUSE
Sequence: MASVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEALFSRINETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYSDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDAEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANPLVKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLHQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGREDASTEQDIVLHGLDLESEHCVFENAGGTVTLIPLRGSQCSVNGVQIVDATQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSCENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETRRKETEIVQRQIRKQEESLKRRSFHIENKLKDLLAEKERFEEERLREQQGLEQQRRQEEESLFRIREELRKLQELNSHEQAEKVQIFQELDRLHQEQNAQSAKLRLEKRRLEEEEKEQVQRVAHLEEQLRKRQDTAPLLCPGEAQRAQEEKRELESIREALLQAKEMRAGGDHTCRDELERAQQYFLEFKRRQLVKLASLEKDLVQQKDLLSKEVQEEKVALEHVKCDAGGDPSFLATDDGNILGGPPDLDKIKTAETRLQSREHQLQDLLQNHLPALLEEKQRVLDALDSGVLGLDTTLCQVEKEVGEKEEQIAQYQANASQLQQLRATFEFTANVARQEEKVRRKEKEILESQEKQQREALEQAVAKLEQRRSALQRCSTLDLEIQEQRQKLGSLHTSEWSGWQASLETDGEALEMDPARLEHEIHQLKQKICEVDGVQRPHHGILEGQAVLSSLPPSGGNSHLAPLMDARISAYIEEEVQRRLHDLHRAIGDANHTPADVMKSNEELHNGTTQRKLKYERMYSRSLGTNRDDLKDPIKISIPRYVLCGQGKDEHFEFEVKISVLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPKKLFGNKDERVVAERRTHLEKYLREFFSVMLQSETSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSSHGTG
What is the function of this protein?
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation.  Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR).  Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.
What are the official names of this protein?
Kinesin-like protein KIF16B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Early endosome membrane. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.
Protein: ACDA2_METMA
Sequence: MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKAKELVKAGPTLFPGLESYRDDWNFKLLDRYEPVVTPMCDQCCYCTYGPCDLSGNKRGACGIDMMGHNGREFFLRVITGTACHAAHGRHLLDHLIETFGEDLPLNLGQSNVLTPNITISTGLSPKNLGEVKPAMEFVEEQLTQLLATVHAGQESAEIDYDSKALFSGSLDHVGMEISDVVQVAAYDFPKADPEAPLIEIGMGTIDKSKPFLCVIGHNVGGVTYMMDYMEENNLTDKMEIAGLCCTAIDLTRYKEADRRPPYAKVIGSMAKELKVIRSGMPDVIVVDEQCVRGDIVPEAQKLKIPVIASNAKIMFGLPNRTDADVNETIEELKSGAIPGCVMLDYEKLGELCIRLTMEMAPIRDASGITAIPTDEELANWVAKCADCGACLIACPEELDIPEAMGFAKEGDYSYLEGLHDICIGCRRCEQVCKKEIPILNIIEKVSQKQIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYAEGTKDVYYIAEEFLKRNFIVVTTGCGAMDIGMFKDDDGKTLYERYPGGFQCGGLVNIGSCVSNAHITGAAEKVAAIFAQRTLEGNLAEIADYILNRVGACGLAWGAFSQKASSIGTGCNILGIPAVLGPHSSKYRRALIAKTYEEDKWKVYDARNGQEMPIPPAPEFLLTTAETWQEAIPMMAKACIRPSDNSMGRAIKLTHWMELHKKYLGGSEPEDWWKFVRNEADLPLANREALLKKLEAERGWEIDWKKKKIISGPKIKFDVSAQPTNLKRLCKEA
What is the function of this protein?
Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.  The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
What are the official names of this protein?
Acetyl-CoA decarbonylase/synthase complex subunit alpha 2, ACDS complex subunit alpha 2, ACDS complex carbon monoxide dehydrogenase subunit alpha 2, ACDS CODH subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the Ni-containing carbon monoxide dehydrogenase family.
Protein: RPO2_SULAC
Sequence: MLDTESRWAIAESFFKTRGLVRQHLDSFNDFLRNKLQQVIYEQGEIVTEVPGLKIKLGKIRYEKPSIRETDKGPMREITPMEARLRNLTYSSPIFLSMIPVENNIEGEPIEIYIGDLPIMLKSVADPTSNLPIDKLIEIGEDPKDPGGYFIVNGSEKVIIAQEDLATNRVLVDYGKSGSNITHVAKVTSSAAGYRVQVMIERLKDSTIQISFATVPGRIPFAIIMRALGFVTDRDIVYAVSLDPQIQNELLPSLEQASSITSAEEALDFIGNRVAIGQKRENRIQKAEQVIDKYFLPHLGTSPEDRKKKGYYLASAVNKILELYLGRREPDDKDHYANKRVRLAGDLFTSLFRVAFKAFVKDLVYQLEKSKVRGRRLSLTALVRADIITERIRHALATGNWVGGRTGVSQLLDRTNWLSMLSHLRRVVSSLARGQPNFEARDLHGTQWGRMCPFETPEGPNSGLVKNLALLAQVSVGINESVVERVAYELGVVSVEDVIRRISEQNEDVEKYMSWSKVYLNGRLLGYYEDGKELAKKIRESRRQGKLSDEVNVAYIATDYLNEVHINCDAGRVRRPLIIVNNGTPLVDTEDIKKLKNGEITFDDLVKQGKIEFIDAEEEENAYVALNPQDLTPDHTHLEIWPSAILGIIASIIPYPEHNQSPRNTYQSAMAKQSLGLYASNYQIRTDTRAHLLHYPQMPLVQTRMLGVIGYNDRPAGANAILAIMSYTGYNMEDSIIMNKSSIERGMYRSTFFRLYSTEEVKYPGGQEDKIVTPEAGVKGYKGKDYYRLLEDNGVVSPEVEVKGGDVLIGKVSPPRFLQEFKELSPEQAKRDTSIVTRHGENGIVDLVLITETLEGNKLVKVRVRDLRIPEIGDKFATRHGQKGVVGILIDQVDMPYTAKGIVPDIILNPHALPSRMTIGQIMEAIGGKYAALSGKPVDATPFLETPKLQEMQKEILKLGHLPDSTEVVYDGRTGQKLKSRILFGIVYYQKLHHMVADKMHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGFGTAMLIKDRLLDNSDKAVVYICDQCGYVGWYDRSKNRYVCPVHGDKSVLHPVTVSYAFKLLIQELMSMVISPRLILGEKVNLGGASNE
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (Ref. 4).  This subunit is involved in DNA promoter recognition (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo2, DNA-directed RNA polymerase subunit B.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_ANOFW
Sequence: MFVDQVKIYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDVVFVVDEGLRTLMDFRYQRHFKAPRGEHGMSKNQHGKNAEDLIVKVPPGTVVIDDETKEVIADLTEHGQRFVVAKGGRGGRGNTRFATASNPAPEIAENGEPGQERYVTLELKLLADVGLVGFPSVGKSTLLSVVSAAKPKIADYHFTTIVPNLGVVETEDGRSFVMADLPGLIEGAHQGVGLGHQFLRHIERTRVIVHVIDMAAIEGRDPYEDYVVINEELKQYNLRLTERPQIIVANKMDMPNAEEHLQQFKQKLNEDVPIFPISAVTRQGIRELLFAIADLLETTPEFPLYPQEEEAIHRVVYKLEKEEAPFHITRDDDGTFILSGEKIEKLFKMTDFSREESVRRFARQLRSLGVDDALRARGAKDGDIVKLLNYEFEFVD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP1G_MOUSE
Sequence: MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK
What is the function of this protein?
Required for normal male fertility.
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, PP-1G, Protein phosphatase 1C catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cleavage furrow. Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome, centromere, kinetochore. Nucleus speckle. Midbody. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Colocalizes with SPZ1 in the nucleus (PubMed:15226296). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (By similarity). Highly mobile in cells and can be relocalized through interaction with targeting subunits (By similarity). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (By similarity). Shows a dynamic targeting to specific sites throughout the cell cycle (By similarity). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (By similarity). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (By similarity). Also accumulates at the cleavage furrow and midbody by telophase (By similarity).
Protein: SYH_TRIL1
Sequence: MSITGIKGFNDLLPAESGLWQFIEQTARQVFARYGFNEIRVPIVEKTELFCRSIGDTTDIVEKEMYTFMDKGGSSLTLRPEGTASVMRALIEHKLYALDSINKLYYMGPMFRHERPQKGRYRQFHQIGAEVTGAADPLIDAQVLLMVSRLFQEFGLTEPRLQINSLGCPACRPAYRQALVAFLAERQEALCEDCRRRQGTNPLRALDCKVPGCIEATQGAPAMVEHLCNECDQHFSMVQNYLTAAEVPFSLNPRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLVEQLGGPAVPGIGFALGVERVALLLGDRSFEKTPDLFIAVMGDAARTAGFRLMAALQDQGFWVETDCEGKSLKSQMRRADKLKSRYSIVLGDTELVAGSGTLKRMADGNQQPVHLEAATIAAAITGGGQT
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_EOSFC
Sequence: MINMRKSHPLLKIINHSLIDLPTPSNISVWWNFGSLLGVCLGLQILTGLFLAMHYTSDTLTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLFLHVGRGMYYGSYNYLETWNIGVILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGTSLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVIVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDILGFIIMFLFLMILVLFSPDMLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILILLPMLHTSAQRSLMFRPISQCLFWILVADLFTLTWIGGQPVEHPFIIIGQLASILYFLIILVMMPLAGILENKIMKI
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y930_LEIXX
Sequence: MTSAAAVRSPGRRRAAVWTTLGVIVALVILFFIFAGLYADILWYQQFGFLSVLTTQWFAAIAMFFVGFLGMALPLWVVIQLAYRLRPVYAKLNSQLDRYQQVIEPLRRLAMYGIPIVFGIFAGVSAASRWQTAAMWINGTPYGKTDPLFHLDIGFYLFALPFYRSAVGFASAVVLISLLATLATCYLYGSIRLSGREVRIARAARVQISVIAAVYLLLQGVSVWLDRYATVTDANVNNMINGAAYTDVSATIPGQAVLAVAAVFVALLFAVTAFTGRWRFPVVGTALLIVAALVIGAIYPWAIQRFQVEPSQKTLETPYIQDSIEATRDAYGLSDIDVVPYNATTSAEAGALRQDAQTTAQIRIMDPAVISPSFQQLQQFRQYYSFPRNLNVDRYTLNGSQQDAVVSVRELNQSGLTSRSWYNDTVVYTHGYGMVAAYGNQRSSDGQPVFMEYGIPTQGTFGAYEPRVYFGQQSPTYSIVGAQKSAKSIELDYPGGDNDAQQTYTTFSGDGGPKLDNIFNRLVYALKFQDEQIVLSTAVNKDSQILYDRDPIKRVKKAAPYLTMDSQAYPAVIDGRIKWVVDGYTTSNQFPYSHVGSLSDAIADTETPKSAYAFDDINYIRNSVKATVDAYDGSVTLYAWDAKDPVLKTWQKIFPSTIKPISAMSAQLLQHVRYPSDLFKVQRSVLGQYHVTDAGSFYSRDDAWTTPNDPTSSPTDPTLQPPYYLTMQMPGQKAPTFSLYTTFIPQAASDSSRSILKGYLAVDADAGSTKGKVAPGYGKLRLLSLPSSDTIPGPGQVQNNFNSDPTVSQELNLLRQGKTDVTNGNLLTLPVGGGLLYVQPVYVKSTGETSYPILQKVLVAFGDKIAFEDTLDQALDSLFGGDSGATAGDNNVPATPGGSGGGSSGDAGSSAGGGSSGGGGSSAGGSSSGSGSSGTQSNAALQRALQQAKQALSDREAALKAGDWAAYGAADSRLQQALQAAIAAEGR
What are the official names of this protein?
UPF0182 protein Lxx09300.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1015_ACIC5
Sequence: MSLAEDIALVARQESALVFEHFDENTAWQLGSRLRQMAVERGYPLVIDVRRFGQVLFTAALPGAVPDQAEWVRRKTNVVARFHRSSYAIGLELAEKQSSLEEKQGLPTVDFATHGGCFPIRVKSAGIIGCVTVSGLPQRADHELVVEAICALTGLDYATYKLPQA
What are the official names of this protein?
UPF0303 protein ACP_1015.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: FZD1_CHICK
Sequence: MAERRGPAGGGSGEVGGGRRAGGDRCPRRPPALPLLLLLWAAALPAGGQPAAQPAALSERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLRCEKFPVHGAGELCVGQNASERGTPTPALRPESWTSNPHRGGGAGGSGPGEARGRFSCPRALKVPSYLNYRFLGEKDCGAPCEPGRLYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTAVAVAYIAGFLLEERVVCNERFAEDGSRTVAQGTKREGCTILFMMLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGINNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFREQWERSWVTQSCKSYAIPCPNNHSSHHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
What is the function of this protein?
Receptor for Wnt proteins.  Functions in the canonical Wnt/beta-catenin signaling pathway.  The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
What are the official names of this protein?
Frizzled-1, Fz-1, cFz-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.