PharMolix/UniProtQA huggingface dataset:
Protein: TRPA_ACIBS
Sequence: MSRLATRFEKLQSQQRKALVSYVMAGDPQPQVTVPLLHKMVAAGVDVIELGLPFSDPMADGPVIALAAERALAAGTNTLDALNMVKEFREQDQETPVVLMGYLNPVEVIGYEKFVSYAKQCGVDGLLLVDLPPEESKEFGAILKQHDMDQIFLLAPTSTDQRIQHVANQASGFIYYVSLKGVTGAATLDTSEAAARIEKIKGMTNVPVGVGFGISDAASAKAMGSVADAVIVGSAFVKSFATLAADEAVEQTVNKVKELRAALDELV
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RLMN_BURO0
Sequence: MTSETSVNLLDFDAEGLVAYCGSLGEKPFRAKQLQRWIHQYNAGDFDGMTDLAKSLREKLKGRASIVMPDIASDHVSTDGTRKWLIDVGNGNAVETVFIPEETRGTLCVSSQAGCAVNCRFCSTGKQGFSRNLSTAEIIGQLRMAEFALRASLGRAPGPNGKAERVVTNVVMMGMGEPLLNYSAVVPAMRLMLDDNAYGLSRRRVTLSTSGVVPMMDRLGAELPVALAVSLHAPNDALRDELVPLNKKYPLRELMAACQRYLKVAPRDFITFEYCMLDGVNDTEAHARELLAVTRDVPCKFNLIPFNPFPESGLIRSKPEQIKRFAQVLIDAGVVTTVRKTRGDDIDAACGQLAGAVKDRTRLAERTGAAGKIIEVRAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
Protein: RPOC_CELJU
Sequence: MKDLLNLLKSQGQVEEFDSIRISLASPEMIRSWSFGEVKKPETINYRTFKPEREGLFCAKIFGPVKDYECLCGKYKRMKHRGIICEKCGVEVTLAKVRRERMGHIELASPVAHIWFLKSLPSRIGLLLDMTLRDIERVLYFESYVVTEPGMTTLERGQLLTDEQYFEAMEEFGDEFEAQMGAEAIQTLMRAIDLETEVQRLREEIPNTSSETKIKKYSKRLKLLEAFHFSGNKPEWMVMEVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPTLRLHQCGLPKKMALELFKPFIFSKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCSAYNADFDGDQMAVHVPLTIEAQLEARALMMSTNNILSPASGEPIIVPSQDVVLGLYWMTRERINAKGEGMVFADTMEVSRAYYSKQVDLQARIKVRLTETLIGAEGERTSETKLVQTTVGRVLLWEIVPAGIPLEMINRPMVKKAISAVINYCYRVVGLKATVIFADRLMYMGYDFSTKSGSSIGVNDFTIPAAKADIIARADAEVKEIETQYASGLVTQGEKYNKVIDIWSRANDLVAKSMMEGISKETVINRDGVEEQQSSFNSVFMYADSGARGSPAQIRQLAGMRGLMARPDGSIIETPIKANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTLQDCGTDSGLTMSPVIEGGDVIESLGDRILGRVVARDVIRPGSDEILVPAGTMIDEAWVGRIEEMGIDEVLVRSPITCESRNGICSMCYGRDLARGHRVNPGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRASAADSVQVKQEGTVRLLNVKVVSNPAGNLVAVSRSGELAIADASGRERERYKIPYGALITVKDGETVKGGQIVAKWDPHTHPIVSEVAGTVAFSGMEEGLSIRRQTDELTGLSSIEILDPAERPSAGKDLRPAITLVDAKGKELFLANTNVPAHYMLPAKAILTINNGDIINVGDIVARIPQEGSKTRDITGGLPRVADLFEARRPKEPAILAEISGTVSFGKETKGKRRLIITPTDGQVLDDGSTHYEVLIPKHRQLTVFEGEMVAKGEVVSDGPANPHDILRLQGVEALARYITNEIQDVYRLQGVKINDKHIETIVRQMLRKVEITTMGDSSFVKGEQVELTSVLEENEKLRAEGKQPAHYERLLLGITKASLATESFISAASFQETTRVLTEAAVTGKKDNLRGLKENVVVGRLIPAGTGLAYHNDRKRRREEALSEQVGVSAEDVEAALTEALKSSVS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: DJC79_ORYSJ
Sequence: MSQVGSAGEGSNSMAAAPPPRLLLLVVLLLVPVSNAIYCEEDDCYDLLGVKQDANVSEIKKAYYKLSLKHHPDKNPDPESRKLFVKIANAYEILKDESTRGQYDYAIAHPEEVFYNTAQYYRAYYGHKTDPRAVLIGLLLIISAFQYLNQFGRYSKAIETVKQTPAYKNRLKALEFERTGGISSKKKGHKQMDKKVEEVLSNEVELQIQGVEKPSLWRLYGVQFILLPYSIGKVLSWKFCWFWRYRIKKLPYAWEDACYLTRMSLKIPANTWENIDDYRKENLVMKRLWEKNNMERYIAEMRKESKRRR
What is the function of this protein?
May play a role in protein folding in the endoplasmic reticulum.
What are the official names of this protein?
DnaJ protein ERDJ7, Chaperone protein dnaJ C79, OsDjC79, Endoplasmic reticulum dnaJ domain-containing protein 7, OsERdj7.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: F10C1_RAT
Sequence: MHGHGGYDSDFSDDEQGGGSSKKRKKTVEDELLLTKPFQKEKYGKVAHKQVAADLLDREEARNRRFHLIAMDAYQRHTKFVNDYILYYGGKREDFKRLGENDKTDLDVIRENHRFLWNEEDEADMTWEKRLAKKYYDKLFKEYCIADLSRYKENKFGFRWRIEKEVISGKGQFFCGNKCCDEKEGLKSWEVNFGYTEHGEKRNALVKLRLCQECSFKLNFHHRRKEIKSTKKRSKTKTESDESPHKNSRSSSSEEASQGKDEGHSSSKRSEDSRNRNAGEEDSASDSELWKGPLPETDEKSQEEEFDDYFQDLFL
What is the function of this protein?
May be involved in pre-mRNA splicing.
What are the official names of this protein?
Protein FRA10AC1 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: TYSY_BACP2
Sequence: MKQYKELCRHVLQHGDEKGDRTGTGTISTFGYQMRFDLQEGFPLLTTKKLHLKSIIHELLWFLKGDTNVKYLQENGVRIWNEWADENGELGRVYGAQWRSWASGDGETVDQITKLIHDIEHNPNSRRLIVSAWNPGEIDQMALPPCHCLFQFYVSNGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAKVTNLEPGEFVHTLGDAHIYQNHLPQVNMQLEREERALPQLRITRDVKSIFDFTFDDFVLENYDPHPHIKGEVSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_MYCVP
Sequence: MDLVVGRVVKAHGVTGELAVDVRTDDPEGRFVAGAVLRGRPARGGAEREFVIESVRSHGDRMLIRLQGVGDRDAADALRGTLFLVDSAELPPIEDPDEFYDHQLEGMAVSTTGGQPVGTVAEVLHTAAGELLAVRDPDGAEVLVPFVSAIVVSVSLADNAIEIDPPEGLLDL
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYNM_DICDI
Sequence: MNNIIKRFYKWPIRINEINKNNKDLIGKEIKVKGWVRNIRNQKSVSFIELGDGSSIKGLQIVGDKDSFSKLKYGSSIEVNGKLINSLGNDKEAIEVQLTEPYKLIGNCPDCYPLQPKNHSFEFLRDIAHIRSRGNSIGALLRVRNKSTQLIHQYFNDNGFINVHTPIITASDCEGGGEQFQIKSSLDTKESMFFGQPSFLTVSGQLEAEIYACSHSRVYTFGPTFRAEKSNTPRHLSEFWMIEPEMAFIDLNDNLDIAEDFCKYLIRNLLDSCKEDIEFFNKRIDTNLLSRLEKTLSTPFIRLEYKDAIQLLQNNNHPIKWGDDIQREQEKFITTHFGEIPVFVINWPKSIKPFYMRENEQTDHSNIMPTVSNMDLLVPTVGELIGGSIREERYDKLLNTINEMGMDKDQYSWYLDLRKYGTVPHGGFGLGFERFLQFVTGLQNIKDVIPIPRHQNYCKF
What are the official names of this protein?
Probable asparagine--tRNA ligase, mitochondrial, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SELU_AERHH
Sequence: MSALPLATDYARIFLDDVPLIDLRAPIEFKEGAFPCSTNLPLMTDDERAQVGTCFKQQGQAAAIALGHQLVGGAVRAERLEGWLAQLRRQPDAVLYCFRGGLRSQTVQQWLHEAGVTRPRIAGGYKDLRRFLIDTLDGAAAECQWTVLTGMTGSGKTHMLAEVAQALDLEGHAHHRGSSFGQLPGGQPSNINFENNLAIELLKRRHQGEQAFVVEDESRLIGRCCLPNPLFDAMSQAPLVVVEVPQEERAEQIRQDYVHDLWLRYQAMFGAEEGWPLFAAYLTDALARLKRRLGDQAHRELDTLMQSALAEQASSGDTSLHLAWITLLLTRYYDPMYLYQLGNKRERIIFQGDKQACLDFFAKQRA
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: GCH4_DESDA
Sequence: MEDVQSHAPQIPLNIDRVGVRELRLPLLVRDRTRGTQQTVASVDLGVDLPSEFKGTHMSRFVEALEQWNDEISYQSVRRLLQDIRQRLEARRAYARFCFPYFISKAAPASGSPALVSYQCRLTGELDDAGQHFILEVDVPVMTVCPCSKAISNEGAHSQRAMVRMRLRMKAFSWLEDFIDIAEASGSSAVYTLLKREDEKYVTEHAFAHPTFVEDVVRNVAQRLSEHGQVEWFSVEVESMESIHNHNAFARIERHISDRS
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: NMU_RANTE
Sequence: LKPDEELQGPGGVLSRGYFVFRPRN
What is the function of this protein?
Stimulates uterine smooth muscle contraction and causes selective vasoconstriction.
What are the official names of this protein?
Neuromedin-U-25, NmU-25.
What is the protein family that this protein belongs to?
Belongs to the NmU family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL24_CLOBH
Sequence: MSKIHVRKKDTVVVISGKDKSKIGEVLSVLPKKGKVIVKDVNVVTKHQKPNRENMQGGIIHKEAPIFSSKVMLYCDKCKSATRISNKILEDGTKVRVCKKCGETF
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: DEOB_SALA4
Sequence: MKRAFIMVLDSFGIGATEDADRFGDVGSDTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLVKAHEGSTGKIAAGMDGNADVIGAYAWAHELSSGKDTPSGHWEIAGVPVLFDWGYFSDHENSFPQELLDKLVKRANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTEGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKQGHVVSVGKIADIYANCGITKKVKATGLDALFDATLKEMKEAGDKTIVFTNFVDFDSSWGHRRDIAGYAAGLELFDRRLPELMELVGEDDILILTADHGCDPSWTGTDHTREHIPVLIYGPKVKPGSLGHRETFADIGQTLATYFGTSPMDYGKNML
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAMB_SALTY
Sequence: MMITLRKLPLAVAVAAGVMSAQAMAVDFHGYARSGIGWTGSGGEQQCFQATGAQSKYRLGNECETYAELKLGQEVWKEGDKSFYFDTNVAYSVNQQNDWESTDPAFREANVQGKNLIEWLPGSTIWAGKRFYQRHDVHMIDFYYWDISGPGAGIENIDLGFGKLSLAATRSTEAGGSYTFSSQNIYDEVKDTANDVFDVRLAGLQTNPDGVLELGVDYGRANTTDGYKLADGASKDGWMFTAEHTQSMLKGYNKFVVQYATDAMTTQGKGQARGSDGSSSFTEELSDGTKINYANKVINNNGNMWRILDHGAISLGDKWDLMYVGMYQNIDWDNNLGTEWWTVGVRPMYKWTPIMSTLLEVGYDNVKSQQTGDRNNQYKITLAQQWQAGDSIWSRPAIRIFATYAKWDEKWGYIKDGDNISRYAAATNSGISTNSRGDSDEWTFGAQMEIWW
What is the function of this protein?
Involved in the transport of maltose and maltodextrins.  Does not act as a receptor for phages.
What are the official names of this protein?
Maltoporin, Maltose-inducible porin.
What is the protein family that this protein belongs to?
Belongs to the porin LamB (TC 1.B.3) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: PSAA_ANGEV
Sequence: MTIRSPEPEVKIVVERDPIKTSFEKWAQPGHFSRTLAKGPNTTTWIWNLHADAHDFDSHTNDLEDISRKVFSAHFGQLAIILIWLSGMYFHGARFSNYEAWLSDPTHIKPSAQVVWPIVGQEILNGDVGGGFQGIQITSGFFQLWRASGITNELQLYCTAIGALIFAGLMLFAGWFHYHKAAPKLARFQDVESMLNHHLAGLLGLGSLGWAGHQVHVSLPINQLLDAGVDPKEIPLPHEFILNRDLLAQLYPSFAKGLTPFFTSNWSEYADFLTFRGGLNPVTGGLWLTDTAHHHLAIGVLFLVAGHMYRTNWGIGHSIKEILEAHKGPFTGEGHKGLYEILTTSWHAQLALNLAMLGSLTIIVAHHMYSMPPYPYLATDYGTQLSLFTHHMWIGGFLVVGAAAHAAIFMVRDYDPTTQYNNLLDRVLRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPIFAQWIQNTHAFAPSLTAPNATASTSLTWGGGDLIAVGGKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNSISIVIFHFSWKMQSDVWGSISDQGVVSHITGGNFAQSATTINGWLRDFLWAQASQVIQSYGSSLSAYGLLFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPAIQPRALSIVQGRAVGVAHYLLGGIATTWAFFLARIISVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: BIOH_XYLFT
Sequence: MYIEVTGYGPALVLIHGWAMHSGVFAPLVEQLRPHHTLYLVDLPGHGYNHTTPTPLALPQVVHAIAAATPPAVWLGWSLGGLFALHAAATLPQVRGLIMLAATPCFVRREDWPHAVEVSILTQFAQDLKQNYTETINRFLALDTLGSTHAQSELRQLRKILNARHTPNTATLQAGLELLAHTDLRRALIDLTPPSLWIAGQRDRLVPAASIQAATVLAPSDQTELLTITGGGHAPFLSHANQMTAALQHFIATLP
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZPI_MOUSE
Sequence: MRVASSLFLPVLLTEVWLVTSFNLSSHSPEASVHLESQDYENQTWEEYTRTDPREEEEEEEEKEEGKDEEYWLRASQQLSNETSSFGFNLLRKISMRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNLQALSQAGPLILPALFKKVKETFSSNRDLGLSQGSFAFIHKDFDIKETYFNLSKKYFDIEYVSINFQNSSQARGLINHCIVKETEGKIPKLFDEINPETKLILVDYVLFKGKWLTPFDPSFTEADTFHLDKYRAIKVPMMYREGNFTSTFDKKFRCHILKLPYQGNATMLVVLMEKTGDYLALEDYLTVDLVETWLQNMKTRKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTSADLSELSAMARNLQVSRVLQQSVLEVDERGTEAVSGTLSEIIAYSMPPAIKVNRPFHFIIYEEMSRMLLFLGRVVNPTVL
What is the function of this protein?
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids.  Also inhibits factor XIa in the absence of cofactors (By similarity).
What are the official names of this protein?
Protein Z-dependent protease inhibitor, PZ-dependent protease inhibitor, PZI, Serpin A10.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HECAM_HUMAN
Sequence: MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLEKQNSLEYMDQNDDRLKPEADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGVHIIREQDEAGPVEISA
What is the function of this protein?
Involved in regulating cell motility and cell-matrix interactions.  May inhibit cell growth through suppression of cell proliferation.
What are the official names of this protein?
Hepatic and glial cell adhesion molecule, glialCAM, Hepatocyte cell adhesion molecule, Protein hepaCAM.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=In MCF-7 breast carcinoma and hepatic Hep 3B2.1-7 and Hep-G2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1.
Protein: Y1812_STAAB
Sequence: MAMTNEEKVLAIREKLNIVNQGLLDPEKYKNANEEQLTDIYDFVQSRERLSPSEVTAIADALGQLRHD
What are the official names of this protein?
UPF0435 protein SAB1812c.
What is the protein family that this protein belongs to?
Belongs to the UPF0435 family.
Protein: NGFV_NAJAT
Sequence: EDHPVHNLGEHSVCDSVSAWVTKTTATDIKGNTVTVMENVNLDNKVYKEYFFETKCKNPNPEPSGCRGIDSSHWNSYCTETDTFIKALTMEGNQASWRFIRIETACVCVITKKKGN
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (PubMed:22649032).
What are the official names of this protein?
Venom nerve growth factor, v-NGF, vNGF, Cobra nerve growth factor, cNGF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: CTNS_CAEBR
Sequence: MKLPVSILFFISVSQILAFNNVIVTQKEVEIGVGETASITFQIKNHTSSTLNQTRIQLSQSPYITNPDVVLVDNWWANVTVSGERPVAGEILEALNCTTDGEEVCSLDLLDAYSRITVIRSHWLAILIQIVGWTYFAAWSVSFYPQMYLNFKRKSVVGLNFDFLSLNLVGFGAYAMFNLLMYYNSHVKNIYSMENPRSPPPVLLNDVVFAVHAFLACFVTILQCIFYERDQQRISTKCIILIIGLVSFGFVSVVVTVLNKITILDFVVSLSYIKMAVTCCKYFPQAYFNYQRKSTVGWSIGNILLDFTGGSLDILQMVLQAINVNDWSAFYANPVKFGLGFVSIFFDIIFMIQHYALYPDAEVPHNEYHGVDNPDPDSIVRDAEHGAADNESMESTDPIIVHD
What is the function of this protein?
Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (By similarity).  May play a role in the degradation of engulfed apoptotic cells (By similarity).
What are the official names of this protein?
Cystinosin homolog.
What is the protein family that this protein belongs to?
Belongs to the cystinosin family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome. Note=During degradation of apoptotic cells when lysosomes fuse to phagosomes, located to phagosomal surfaces until the cell corpse is fully degraded.
Protein: NLTP1_PRUDU
Sequence: MAYSAMTKLALVVALCMVVSVPIAQAITCGQVSSNLAPCIPYVRGGGAVPPACCNGIRNVNNLARTTPDRQAACNCLKQLSASVPGVNPNNAAALPGKCGVNIPYQISPSTNCANVK
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).
What are the official names of this protein?
Non-specific lipid-transfer protein 1, LTP 1.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: DHRS7_ANOGA
Sequence: MKNLAERSAGSLYWWLLATLFLPIAIPGLVLKLLTMMKEQRNARHLNGKVVLITGASSGLGEALAHSFFLAGCKVVLAARRKDELERVRKDLLELHATVPTHPPIILPLDLSDLNSIGGKVQSVLEIHGAIDILVNNGGISVRGDALSTAIDVDIRIMLVNYFGSVALTKACLPSMMARKEGRIVSISSVQGKFAIPHRSAYSASKHAMQAFCDSLRAEVAKDNIKVTLISPGYINTALSLNALTGTGASYGKMDAATAGGASPQDTASSILKAIARDEKDVMLAPIAPRAAYWLRHLAPSVYFWIMKKRAEKLNST
What is the function of this protein?
Putative oxidoreductase.
What are the official names of this protein?
Dehydrogenase/reductase SDR family protein 7-like.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass type II membrane protein.
Protein: RN168_MOUSE
Sequence: MAAPKTSIPSLAECQCGICMEILLEPVTLPCNHTLCNPCFQSTVEKANLCCPFCRRRVSSWTRYHTRRNSLVNTDLWEIIQKHYAKECKLRISGQESKEIIDECQPVRRLSEPGELRREYEEEISRVEAERQASKEEENKASEEYIQRLLAEEEEEEKRQREKRRSEMEEQLRGDEELARSLSTSINSNYERNTLASPLSSRKSDPVTNKSQKKNTSKQKTFGDIQKYLSPKLKPGTALACKAELEEDICKSKETDRSDTKSPVLQDTEIEKNIPTLSPQTCLETQEQGSESSAGIPGPQLCVGDTKESLEGKVETVSTSPDDLCIVNDDGPRATVFYSNEAAVNSSSKIENEEYSVTGVPQLTGGNRVPTESRVYHLLVEEEISDRENQESVFEEVMDPCFSAKRRKIFIESSSDQEETEVNFTQKLIDLEHMLFERHKQEEQDRLLALQLQKEVDKEQMVPNRQKGSPDQYQLRTPSPPDRLLNRQRKNSKDRNSLQQTNADHSKSPRNTKGDYWEPFKNTWKDSVNGTKMPTSTQDNCNVSKSAYTVQHRKSQRSIVQMFQR
What is the function of this protein?
E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage.  Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination.  Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates.  This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1.  Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair.  H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates.  Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair.  Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites.  Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region.  Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF168, RING finger protein 168, RING-type E3 ubiquitin transferase RNF168.
What is the protein family that this protein belongs to?
Belongs to the RNF168 family.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage.
Protein: CCMA2_SALPA
Sequence: MLEARDLHCERDERTLFSGLSFTVDAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHRSLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTGGEAGL
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA 2, Heme exporter protein A 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.