PharMolix/UniProtQA huggingface dataset:
Protein: VIPR1_PIG
Sequence: MRPLSPPPAGWFCVLAGVLACVLGPVGSWAVGLQQEECDYLQMIKVQHKQCLEEAQLENETSGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSPTQGLNVSRNCTDEGWTPLEPGPYPIACGMDDKASGLDEQQTVFYNSVKTGYTIGYSLSLAALLVATAILSLFRKLHCTRNYIHMHLFISFILRATAVFIKDLALFDSEESDHCSKGSVGCKAAVVLFQYCVMANFFWLLVEGLYLHTLLAVSFFSERKYFWGYIFVGWGVPSTFIMVWTVVRIHFEDYGCWDTIHSSLWWIIKAPILASILVNFILFIRIIGILVQKLRPPDVGKSDNSPYSRLAKSTLLLIPLFGVHYIMFAFFPDNFKAEVKMVFELIVGSFQGCVVAILYCFLNGEVQAELRRKWRRWHQQGVLGWDSKYQHPSGGSNGDTCSTQVSMLTRVSPSARRSSSFQAEVSLV
What is the function of this protein?
This is a receptor for VIP.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
What are the official names of this protein?
Vasoactive intestinal polypeptide receptor 1, VIP-R-1, Pituitary adenylate cyclase-activating polypeptide type II receptor, PACAP type II receptor, PACAP-R-2, PACAP-R2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ZFY27_CHICK
Sequence: MQAAERDGVAGGLEATAAVAATGGGEASSEPPSPPKAASFDLLDLVRSYRRLELYLEPLRDAAEGVRALLRWQRPLCSLLVCLGLNFLLLTLDQAAWYSVLALLVLLPALLGYLQETYRVRPSERELLRRKYHSVRREDLRRVQLSRQEALAQVKCFLIQLEGFLSGLCYNCEAVYRVLYWENPTVSSQFYGALLGSVCILYLLPLCWVMAILNSTLFLGNSQFYQVIKELKASVEQSLGTKPLESAPEPAKPLPTDAPPDRTPTPTSTEDLTPGSVEEAEEAEPDEEFKDAIEEDDEGSQCSADFDLSLPDNGFMSKNDVIRSKVSRLTERLRKRYPSNNFGTCTGCGATFSVLKKRRSCSNCGNSFCSRCCSFKVPKAVMGATAPEAQRETVFVCAQCNQMLIK
What is the function of this protein?
Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport.  Promotes axonal elongation and contributes to the establishment of neuronal cell polarity.  Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner.  Contributes to both the formation and stabilization of the tubular ER network.  Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections.
What are the official names of this protein?
Protrudin, Zinc finger FYVE domain-containing protein 27.
What are the subcellular locations of this protein?
Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi-pass membrane protein. Note=Localizes to endoplasmic reticulum tubular network.
Protein: Y2686_SHESR
Sequence: MQYPVDTHTHTVASTHAYSTIHDYLAVAKQKGIRLFATTDHGPAMADAPHFWHFVNLRVLPRMVDGVGILRGIEANIKNREGEIDYFGDYLSQLDIVLAGFHEPVFPPSDKATHTEAMINAIKSGKVDIITHPGNPAYPIDIEAVVTAAAEYGVALEINNSSFEVSRKGSEANCTAIAKAAKELGATLVMGSDSHVAFSLGGFDRALSIIEAVDYPKDKLLNRSPMALLNFLAQRGHKSVADLMPLFSDDIA
What are the official names of this protein?
Probable phosphatase Shewmr7_2686.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: MGRA_STAAW
Sequence: MSDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVTELALDTGTVSPLLKRMEQVDLIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASASSLSQDEVKELNRLLGKVIHAFDETKEK
What is the function of this protein?
Regulatory protein involved in autolytic activity, multidrug resistance and virulence.
What are the official names of this protein?
HTH-type transcriptional regulator MgrA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_STAAC
Sequence: MSSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEVTGKDASQFVQYLLSNDTDNLTTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANTEKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLINQLVDEDVTEMKMFEFKQGVKLFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLHGQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGYEVMDLDGNIIGEVTSGTQSPSSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQIDK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: FYNB_DANRE
Sequence: MGCVQCKDKEAAKLTDDRDTSLSQSGVGYRYGVDPTPQHYPAFSGTGTAVAAIPNYNNFHGAAVSQGMTVFGGISTSTHQGTLRTRGGTGVTLFVALYDYEARTEDDLSFRKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTFLIRESETTKGAFSLSIRDWDDVKGDHVKHYKIRKLDSGGYYITTRAQFETLQQLVQHYTERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMGKGSLLDFLKDGEGRALKLPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQDCPSSLHELMVQCWKKDAEERPTFEYLQAFLEDYFTATEPQYQPGDNL
What is the function of this protein?
Tyrosine-protein kinase implicated in the control of cell growth.  Plays a role in the regulation of intracellular calcium levels.  Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension.  Role in CNTN1-mediated signaling (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase fynb, Proto-oncogene c-Fynb.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED10_CHAGB
Sequence: MAPINPDLQNVQDDIKNVIQDLFQVLVQVSNYDAAGRPTRDVLAQDIQTLDKTLHTLHTNAQHLPTPTADKPIPEPLIQYVENGRNPDIYTREFAELVRRMNQLARGKMHAFRDFRDVLAREMESALPELRADVQMVVGATGGRTVGGEGEGAGQGEGGEGRGEGGN
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 10, Mediator complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UNG_PSET1
Sequence: MSDWTAFLKQELQQAYMQQTLDYVAKRRSEGVAVYPPKDQVFSAFTATQLSDIRVVILGQDPYHGEGQAHGLCFSVLPEVKKLPPSLKNIYKELASDINDFVIPTHGYLQSWAEQGVFLLNTVLTVEQGQAHSHKHLGWEQFTDKVITHINTHCEGVIFILWGAHAQKKGKGIDSARQHILAGPHPSPLSAHRGFFGCRHFSATNALLQSQGKTPINWQV
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADD_SHEFN
Sequence: MRIGILGGTFDPIHLGHINPALDVKQQLHLDQIWLMPNHIPPHKNTTVVSTHHRLEMVKLVCQQYPEFKLCDIEINRDTPSYSVTTLTLLTQQYPDDEFFFIMGMDSFVQLPLWYQWQSLFNLCHIALCQRPGWAMDTNSEMTKELLFRQATADYLDSPSHAKNGRIFTINSQLVDISSTEIRQQLAQNIDISTVLSQTTTEYIRQHQLYR
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: PFKA_BACC3
Sequence: MKRIGVLTSGGDSPGMNAAIRAVVRKAIFHDIEVYGIYHGYAGLISGHIEKLELGSVGDIIHRGGTKLYTARCPEFKDPEVRLKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEQGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTYVIEVMGRHAGDIALWAGLADGAETILIPEEEYDMEDVIARLKRGSERGKKHSIIVVAEGVGSAIDIGKHIEEATNFDTRVTVLGHVQRGGSPSAQDRVLASRLGARAVELLIAGKGGRCVGIQDNKLVDHDIIEALAQKHTIDKDMYQLSKELSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_CLOBJ
Sequence: MAKVKITLVKSLIGRKKDQIATVNALGLKKIGNIVEHEETPQISGMIKKVSYLLKVEEA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: DCL1_ASPOR
Sequence: MPPLEVKPLAGYVRSQSLRIPSSLNLSGERTISTTEPTEGNDSSSEESGDNEQISTQRLISQNKRLQSAKFEALLSERADTLTGNSGRPTLDLPDAELSTASLVAKQDAGTGMLDPREYQVELFERAKSQNTIAVLDTGSGKTLIAVLLLKHIIQNELIDRANGKPPRISFFLVDSVTLAFQQAAVLRNNLDQNVAQFFGAMGTDLWSKQTWDHQFENNMVIVCTAEILNQCLLNSYIRMDQINLLIFDEAHHTKKDHPYARIIRESYLKADPTKRPRIFGMTASPIDTKGDIIESATKLEVLLDSKIATTSKPNLLREVVRRPIEESWEYDKLDPPFATKLYQILQARFGDISSLQPVFRFTLQASSELGPCCADRAWAYALADDVLPKLEGNVRKLAQSISSPIPQCALKEISRIQEASDIVKNHSFNSPNVPGELSPKVQLLRQKLIKYFEHPTKTKCIVFTQKRYTAKMLFDLFSTLEIPYLRPGVLIGVRSGDIVGMNVSFRQQFLALVKFRSGEINCLFATSVAEEGLDIPDCNLVVRFDLYNTLIQYVQSRGRARHSSSTYASMIERYNADHAARLVEVREAEKLMQSFCETLPEDRILHGIDSEIDSILQGEEEKRTFIIRATGAKLTYHSALAILARYASSLQYEKETSAQATYVVLPQNNSFVCEVILPEKSPVRGLTGVPASKKSAAKQSAAFDTCVLLRKHKLLDDHFNSVYHRRLPAMRNARLAITSSRTNQYDMLSKPSLWGKQQGTLPEKLFATVISFIPSEPLRRRHRSIILLTRERLPDFPSFTIFLDDDIETIVVTESVEEALHISSQELEYLSTFTFRIFHDVFHKTYAEEPEKLPYWVAPAETKKSKNVSDSKSLTDWELLHLVHENEEIPSTLHPSSEALINRFVFDPWDGRYRYFTMAIDNTLHPSDPPPSFLPRRKFMESIMSYTLSGSKNARAGFLSRCNWQQPVLEVELVRLRRNLLDKMTDTEKDVETRCFVCIEPLRISAIPEEIAASCLAFPAIINRLDAYLIALEGCKTLDLSVKPEYALEAFTKDSDNTEEHRVQQIHVQRGMGKNYERLEFLGDCFLKMATSISLFVQNPDDDEFDFHVNRMCLICNKNLFNTALKKELYQYTRSRGFSRHTWYPDGLTLLHGRDHRKKISAESKHALREKTVADVCEALIGASLLSGGLHNQFDMAVKAVTAVVDSPNHKALCWADYTSSYMLPKYQTQSPDGYELDLGRKVEEKLGYRFKYPRLLHSAFTHPSYPSTWAKVPCYQRLEFLGDSLLDMVCVDDLFYRYPDKDPQWLTEHKMAMVSNKFLGALAVKLGLHTHLRHFSNPLQSQITHYAEEIQAAENESQGAVDYWLVTKDPPKCLPDMVEAYLGAAFVDSDFQFRVVEDFFQRHVKSYFHDMTIYDTFANKHPTTFLQNRLTNEYGCTNYCLKAGEIPVVDGGTVSVLAAVIVHEVVIAEGTASSGRYAKVKASEKALSVLENMGPSEFREKYHCDCRTANGSQPMDIGTAI
What is the function of this protein?
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway.  Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS).  Part of a broad host defense response against viral infection and transposons (By similarity).
What are the official names of this protein?
Dicer-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Dicer subfamily.
Protein: MCR1_USTMA
Sequence: MFIRPVLSSSLGHAARSSLRSQAPAVRQYATEAGKSSGGSNLPLVLALGGVAGIGAWYGLGGFDDPKKVSNKIQEKGKEAVDQAKGAVEGGALNKDQFVEFTLKEIKPYNHDSATLIFELPEGKKPGMGVASAVVVKAVGDGLKDDQGKDVIRPYTPITSPDTVGHMDFLVKKYPGGKMTTYMHSMKPGDKLGIKGPIAKFAYKANEFESIGMIAGGSGITPMYQVIQDIASNPSDKTKVTLIYSNKTEQDILLREQFDQLAKKDDRFTIIYGLDKLPKGFNGFEGYVTEDLVKKHLPQPELADKAKIFVCGPPPQVEAISGKKGPKGSQGELKGLLAKLGYQADQVYKF
What is the function of this protein?
May mediate the reduction of outer membrane cytochrome b5.
What are the official names of this protein?
NADH-cytochrome b5 reductase 2, Mitochondrial cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: 7B2_PANTR
Sequence: MVSRMVSTMLSGLLFWLASGWTPAFAYSPRTPDRVSEADIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPVGKTDDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDPE
What is the function of this protein?
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway.  Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated.  Also required for cleavage of PCSK2 but does not appear to be involved in its folding.  Plays a role in regulating pituitary hormone secretion.  The C-terminal peptide inhibits PCSK2 in vitro.
What are the official names of this protein?
Neuroendocrine protein 7B2, Secretogranin-5.
What is the protein family that this protein belongs to?
Belongs to the 7B2 family.
What are the subcellular locations of this protein?
Secreted. Note=Neuroendocrine and endocrine secretory granules.
Protein: GLPK1_STRAW
Sequence: MTDAHTAGPFIAAIDQGTTSSRCIVFDRDGRIVSVDQKEHEQIFPKPGWVEHNAAEIWTNVQEVVAGAVEKAGITRDDIKAIGITNQRETTLLWDKNTGEPVHNALVWQDTRTDALCKELGRNVGQDRFRRETGLPLASYFAGPKARWLLDNVEGLRERAEAGDILFGTMDTWVIWNLTGGVNGGKHVTDVTNASRTMLMNLHTMQWDDKIAESIGVPLAMLPEIRSSAEVYGEITGGKLGDLLGGIPVASALGDQQAALFGQTCFSEGEAKSTYGTGTFMLMNTGDKIINSYSGLLTTVGYQIGDQKPVYALEGSIAVTGSLVQWMRDQMGLIKSAAEIETLASSVEDNGGAYFVPAFSGLFAPYWRSDARGVIAGLTRYVTKAHIARAVLEATAWQTREITDAMTKDSGVELAALKVDGGMTSNNLLMQTLSDFLDAPVVRPMVAETTCLGAAYAAGLAVGFWTNTEDLRANWRRAAEWTPNMAAETRDREYKSWLKAVERTMGWIEDEE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase 1, ATP:glycerol 3-phosphotransferase 1, Glycerokinase 1, GK 1.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: LPXD_WOLSU
Sequence: MKLSLIAQFLELPLPSIEKEIVGISSLEGATPDEISFVEQDRYASSLKESRAGAVLIRASLLSLVPQGCTPLVSAHPYLDMARLSKLFAKPPLGLNAQEPQIAPSAQIAPSATIGKGAVIGERTIVMAGAVIGEGVCLGEDCLIYPNVVIYRDTQIGNRVFIHAGSVIGSDGFGYAHTERGEHIKIHHNGIVVIEDDVELGANNCIDRAVFGETRIKRGTKIDNLVQIAHNCVLGEHSIVVSQVGLAGSTTTGRNVIFGGQSATSGHLHVGDFATIAARGGVSKSIEGKKTYAGFPLMEHKEWLKLQASLKHQLKKSQ
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: TRUB_FRATO
Sequence: MKKNRLNLNGVVVINKAKDISSNKVLQQLKYLFNAQKAGHTGTLDPMATGVLPICFGRATKIAQYLLDADKEYIATIRLGIETDSGDAEGEIIAKSINIPELSAEYLEIVLAKFSGDVVQIPPMYSALKYNGQPLYKLAREGKTVEVKSRNIKIYELELLEFNIDSLKIRVKCSKGTYIRSLAIDIGKTLGCGGHLIALQRTQSGPFKLSEAFRLEQLKDLSFEQKIASITNIESVFIDKPIYSLLEEEKNDLYKRGLFADKPHLDGTVRIYDVEKFVAIAEFDKGKLINKKFFDQDILISE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: YORF3_NORAV
Sequence: MALKEEIFDQNTTLFAVLDENEVTEIKSIQSSVTAVKTQLDQQKLQLDGLAKVVDNNQARNEEQFVNINTTLVEMSSEVDKLTITTSQQAKQINTLATTLNELDQTTKDSLDTLNTTTESLKKQVLFNTDEITVLKVDVATVTQKQQDVEHSLVTMKDEIGELHVSVNANANSIEALRTRIAALEIRDVGPWVLKDRIYKFVINKPNGTTRYTTIYFFADVYYSTGVRAAPTNSGTATSILTITSLTTSYSLANVPVLKGVPYRVNGYFANGNNIEDITGSTSVIYDSM
What are the official names of this protein?
Uncharacterized ORF3 protein.
Protein: IL2_MOUSE
Sequence: MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIISTSPQ
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:9814585, PubMed:14614860).  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 (PubMed:14614860, PubMed:27018889).  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance (PubMed:14614860).  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells (PubMed:9814585).
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LYRM7_HUMAN
Sequence: MGRAVKVLQLFKTLHRTRQQVFKNDARALEAARIKINEEFKNNKSETSSKKIEELMKIGSDVELLLRTSVIQGIHTDHNTLKLVPRKDLLVENVPYCDAPTQKQ
What is the function of this protein?
Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex.  Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
What are the official names of this protein?
Complex III assembly factor LYRM7, LYR motif-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
Protein: NADE_METMA
Sequence: MDLENAQNRIIDFIRDETGRAGVKGVVVGISGGIDSALTATLAVKALGKDRVLGIHMPESSLTPAVDSEDAEALADWLGIEYRTIDISGIISAFMAAVPESESADRLTKGNLKARTRMSLLYFHANRLNRMVIGTGNKTEILLGYYTKYGDGGVDLEPIGGLYKTGVWELSSRLGIPESLITKKPSAGLWAGQTDEADLGISYVKVDEVLKMIEDGVEPEVILDKTGISADQLNSVTRRIERNEHKRKAPPVPELY
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: NMD4_YEAST
Sequence: MTQYNFIIDASAFEKGLGNIKRWCSDCTEAVTLNFYIPTFTLNELDFLQQRRKSFAARESLKFIDRLDDSKFANLKVFIEFPEVLDIILWSDVMEHNDSSGKINIAKLPKRLKNLLKSCIYKCYLEGNEGLHWFLISEDPQIREMAMQCNIPSCSIVDVDSILSKDMNDKSFRESEKFNNMMLKNGTKEESENGREIIRTNFNKTVYASRGTGELWSP
What is the function of this protein?
Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
What are the official names of this protein?
Nonsense-mediated decay protein 4.
Protein: GPDA_CHLTR
Sequence: MKETIAYLGMGMWGFSLANLLANNGHRVVGWARNPALIEQLSVQRRHPAAPHISIPQNLSFTSHMEEALDGATMIVEGVTSAGMRPVLTQLKALTELRVPLVITSKGIEQNTGLLLSEIALEIFGRPAAQHLGYLSGPSIASEVLRGCPCSVVISAYNPDTLKQIHRAFLTPTFRVYPNSDLKGVALGGALKNVIAIACGISDGFRFGDNAKSGLVTRGLHEIRKFATIMGCRPDTLNGLAGLGDLCTTSFSAFSRNTLFGKLLAEGLTPEQAKTKIGMVVEGVYTALSAHQIATHHRIDMPITTSVYRVLYENLDIQEGIAQLLQRDTKEEYL
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_ALIF1
Sequence: MLKNINPTETQAWADLTAHFETAQDFNLSDLFAADAQRFDKFSATFGQDILVDFSKNLITEETMKKLFALAEQTELSSAITAMFSGEKINKTEGRSVLHTALRNRSNTPVMVDGEDVMPAVNAVLEKMKGFTERLISGEWKGYTGKEITDIVNIGIGGSDLGPYMVSEALAPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKHFAALSTNAQSVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFIELLEGAHEVDKHFAETDLENNVPVILALIGLWYNNFHGAESESILPYDQYLHRFAAYFQQGNMESNGKCVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAISHNQVGDHHQKLMSNFFAQTEALAFGKTEETVKAEFAAAGKTEAEVAELVPFKVFEGNRPTNSILVKQVTPKTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAVTSHDSSTNGLINAFKAFQA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PITH1_XENLA
Sequence: MSHGHSHGGGCSCESEPSDGPERGLEYGLFRKIDLDKLQCLNESREGSGRSVFRAWEERNDRTRFVESDDDEELLFNIPFTGNVKLKGIVLIGEDSDTHPAELRLFKNVPHMSFDDTGREADQTFSLNIDVNGNLEYPTKIARFSNVSHLSIHISKNFGAENTKIYYIGLRGEWTEAHRHEVTICNYEAAANPADHKVSQITPQTNFIS
What is the function of this protein?
May play a role in promoting megakaryocyte differentiation by up-regulating RUNX1 expression.
What are the official names of this protein?
PITH domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PITHD1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCHCR_PANPA
Sequence: MFPPSGSTGLIPPSHFQARPLSTLPRMAPTWLSDIPLVQPPGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIARQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLQATVELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEEAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVADVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLERELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPIAAAVPTRESIKGSLSVLLDDLQGLSEAISKEEAVCQGDNLDRCSSSNPQMSS
What is the function of this protein?
May be a regulator of keratinocyte proliferation or differentiation.
What are the official names of this protein?
Coiled-coil alpha-helical rod protein 1, Alpha-helical coiled-coil rod protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PDXS_CLOPA
Sequence: MGYDINXXLAQMXKGGVIMXXXXXXQAVI
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.