PharMolix/UniProtQA huggingface dataset:
Protein: RLMN_LEGPL
Sequence: MDQQKVNLLNYNYLQLRELLMAWDEKPFRAQQLFQWIHQVGIRDFAQMTNLGKVLRNKLSQLACIDLPEIVACQKSADGTHKWLLKLECGNCIETVFIPEANRGTLCVSSQVGCALNCSFCSTAKQGFNRNLSTAEIIGQVWLAARELSDNDGTHDKKITNVVMMGMGEPLLNFDNVVSAMNIMMDDLAYGLSKRRVTLSTSGVIPEMERLREVSPVALAVSLHAPTDELRNELVPINKKYPLSQLISLCKRYFKDEPRRKVTFEYVMLKGVNDQPEHASQLIKLLHNVPAKVNLIPFNPFPLTQYQRSSRETIDAFRDKLMKHGINTITRKTRGDDIDAACGQLAGEVKDKTSRSQRWQKLHFMSKTDKSTELTISSEEIA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_THIDA
Sequence: MKNPIIAREGWLVLLAAFGAALIATWLIGWWSVPFWIWAVFALQFFRDPARVPPADADAVISPADGRIVSVEKVRDPHLERDALKISVFMNVFNVHSNKSPVDGEIKARWYTPGSFVNADLDKASTENERNALWIQSERGDVVAVQIAGLIARRILCYVRTGDRLLRGQRYGFIRFGSRVDVYLPTSARAAVSIGQKVTGGRTILARF
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DAPD_BURP0
Sequence: MSQQLQQIIDNTWENRAELSPKAASAEIREAVAHAIEQLDRGALRVAEKIDGAWTVHQWLKKAVLLSFRLEDNAPMPAGGYSQFYDKVPSKFANYTAEDFAAGGFRVVPPAIARRGSFIAKNVVLMPSYTNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPVIIEDNCFIGARSEVVEGVIVEENSVISMGVYLGQSTKIYDRETGEVTYGRIPAGSVVVAGNLPAKDGTHSLYCAVIVKKVDAKTRAKVGLNELLRGD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YYAL_BACSU
Sequence: MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENKPVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQLMTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDIAENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYLLRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNALLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVWSKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSLKLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAITFIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTDDMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLSLIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAELQKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIHTLISSRD
What are the official names of this protein?
Uncharacterized protein YyaL.
What is the protein family that this protein belongs to?
To C.elegans B0495.5.
Protein: ID2B_HUMAN
Sequence: MKAFSPVRSIRKNSLLDHRLGISQSKTPVDDLMSLL
What are the official names of this protein?
Putative DNA-binding protein inhibitor ID-2B, Inhibitor of DNA binding 2B.
Protein: ENGB_COXBU
Sequence: MTEFKSAPAYQEAKYLTSAAEFDQLPPDQGAEIAFIGRSNAGKSSALNIITGIKGLARTSKTPGRTQMINFFALNEHERLVDLPGYGYAKVPRMVQKRWEELVDSYLKNRRCLKGLVVVMDIRHPLKEMDEDVIEWAVNYDIPIHILLTKSDKLSQNAAKKTLGEVQTAISAYGEKLTLQLFSSHDRTGLDEVKAVLSQWFRSEP
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: DXS_PELTS
Sequence: MGRLLEQISSSRDIRSLTFKQLNELAGEIRQVLINTVSKTGGHLAPNLGVVELTLGLHRVFHSPVDKIIWDVGHQSYVHKLITGRYKEFYTLRQFGGISGFPRPSESVHDAFGTGHSSTSISAALGMAIARDLKGEKYSVVAVIGDGAMTGGIAFEALNHAGHLKCNLIVVLNDNEMSIAQNVGAMSGYLTRLRTDPMYSRGKEEIEQLLRRIPIGSALLRLGERVKDSLKYLVVPGMIFEELGFTYLGPVDGHDLRAITTVLQHARARKGPVLVHVLTKKGKGYSPAESNPDRFHGIGAFDVATGEAVKKSNIPTYTEVFGRTMVKLAREFDNMLAITAAMTGGTGLTEFARLYPKRFFDVGIAEQHAVTLAAGMATGGFRPVVAIYSTFLQRAYDQILHDVCLQNLPVTFAIDRAGIVGEDGATHHGLFDFSYLRPIPNMVIMAPKDENELQHMLYTALSHPGPAAVRYPRSAGTGCRMDDSFKIIPLGRAEVLRDGTEVTLLAVGSMVCLAVKAAEILAGHGIDAAVINARFVKPLDKECILRYARRTREVFTLEENVLQGGFGSAVQELLSSCGERGVSVHCFGIPDSFVEHGNRALLLARYGLTVEQVVRAVLERFAQRRHPKKLKVVSEKA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RK16_SPIMX
Sequence: MLSPRRTKFRKQHRGRMKGVATRGNQIAFGRFALQAMEASWITSRQIEAGRRAMTRYARRGGKLWIKIFPDKPITMRPAETRMGSGKGAPEYWVAVVKPGRILYEMSGISETIARAAMRIAAYKMPIKTRFIVANLSKNPTND
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HIS7_TORDE
Sequence: MSERKAFVSRITNETKIQIAISLNGGHIEIKDSILCKKQQENGSDVAAQTTKSQVIDIQTGVGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGQVRGVKRFGTGFAPLDEALSRAVVDLSNRPYAVIDLGLKREKIGDLSTEMIPHFLESFAEAARLTIHVDCLRGFNDHHRSESAFKALAVAIRESLAPNGTNDVPSTKGVLM
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
Protein: CH10_BACCR
Sequence: MLKPLGDRVVIELVQAEEKTASGIVLPDTAKEKPQEGKVVAVGTGRVLENGERVALEVAAGDLIIFSKYAGTEVKYEGTDYLILRESDILAVIG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_MARN8
Sequence: MTVRTRIAPSPTGDPHVGTAYVALFNLCFARQHGGQFILRIEDTDQARSTAESEQDILTALRWLGLNWDEGPDVGGPHGPYRQSERKHMYGQYAEDLVTAGHAFYCFRTPEELDAIREERKAQGLNPGIKGDLELPEEEVKRRLDAGDPYVIRMKVPDEGVCEIQDMLRGTIEIDWAQVDCQILLKSDGMPTYHLANVVDDHLMGITHVLRGEEWINSAPKHKLLYQYFGWDMPELCHLPLLRNPDKSKLSKRKNPTSINFYERMGFLPEAVTNYLGRMGWSMPDEREKFTLDEMIENFDIQRVSLGGPVFDVEKLRWLNGQWIREELSDEQFMARMQQWWFNQDDLKALVPHIKGRAEVFSDVAPMAQFMFSGMLNLKPEDFAHNKLDESQVKRVLQFALWKLEAQRHWSKNTIFADIKALAKAMDLKMGDFMFSIFVAIAGTPNSWSVMDSMALLGPDMTRSRLRHALEVMGGFSKKETKKVEKEYAALGV
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXOS1_HUMAN
Sequence: MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  It seems to be involved in degradation of histone mRNA.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
What are the official names of this protein?
Exosome complex component CSL4, Exosome component 1.
What is the protein family that this protein belongs to?
Belongs to the CSL4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus. Cytoplasm.
Protein: ISPF_VEREI
Sequence: MNLRIGEGWDVHALVPGRRLVIGGVELEHPMGLGLLGHSDADVLLHAITDALLGAAALGDIGRHFPDTDAAFRAADSRLLLAEAARRVRAAGYEIGNIDSTVVAQAPRLAAHIPAMRLAIARALGVDQGQVNVKAKTAEGLGPVGQNLAIEARAVALICATPGAGAIGPAAQRVSSAWSGSGA
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: ATPE2_THIDA
Sequence: MAMTIHVDIVSAEKSLYSGTAEMVIAPGQRGELGIYPRHTPLLTTLRPGSVRIKAPNQDEEELVYVSGGILEVQPHLITILSDSAVRGADLDEAKALEAKRAAEEAMKDKAATLDYAQAQAELAQAVAQLAAIKKLRKLP
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain 2, ATP synthase F1 sector epsilon subunit 2, F-ATPase epsilon subunit 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FABZ_NITHX
Sequence: MESPIKFEEVDIATILKTLPHRYPFLLIDRVINIRADHSGIGVKNVTINEPAFQGHFPERPVYPGVLMIEGMAQTAGVIGITSVEGTEKPRAVYFLTIDKCKFRKPVMPGDIVEYHMRSIGRRKTMWWFHGDAKVNGATVAEADVGAMLTD
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_BACAH
Sequence: MFEYVTGYVEYVGPEYVVIDHNGIGYQIFTPNPYVFQRSKQEIRVYTYHYVREDIMALYGFKTREERLLFTKLLGVSGIGPKGALAILASGQTGQVVQAIEHEDEKFLVKFPGVGKKTARQMILDLKGKLADVVPDAFVDLFSDEERFDEKKGSSAELDEALEALRALGYAEREVSRVVPELLKESLTTDQYIKKALSLLLNGKR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ITB5_BOVIN
Sequence: MPRAPALLFSCLLGLCALVPRLPGLNICTSGSATSCEECLLIHPKCAWCFKEDFGSLRSVTSRCDLKANLIRNGCGVEFESPASSTQVLRSLPLSSKGSSPAGSDVIQLTPQEVTVTLRPGDRTAFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSLGTKLAEEMRKLTSNFRLGFGSFVDKNISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNILQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRKCEGLKIGDTASFEVSVEARSCPSKHVQHTFTLRPVGFRDSLEVGVTYNCRCGCSAGLEPDSARCSSNGTYVCGLCECNPGYLGTRCECQEGESQSGYQNLCREAEGKPLCSGRGQCSCNQCSCFESEFGKIYGSFCECDNFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCQARDGHICSDRGHCVCGQCQCTEPGAFGETCEKCPTCPDACSTKRDCVECLLLHSGSSADNQTCQNLCKDEVITRVDTIVKDDQEAVLCFYKTAKDCVMMFTYSELPSGKSNLTVLREPECGTAPSAMTILLAVVGSILLTGFALLVIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFTFNKFNKSYNGTVD
What is the function of this protein?
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin.  It recognizes the sequence R-G-D in its ligand.
What are the official names of this protein?
Integrin beta-5.
What is the protein family that this protein belongs to?
Belongs to the integrin beta chain family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: Y1442_YERPE
Sequence: MKLGLVAGMLAVCFSFSSVAMTLKLTPEIDLLVVDGKNMSGSLLKGADSLELNSGMHQILFKVIKPLPTDPLVLYSSPPLIVVFNAHNTRSVAIKLPVINTLRDGHQFSKNPLYQLIGDNGHPLSVRHDVLRQDHLNNSTTLETVMAAYNVGKYNASVPAFAAIPPSPVSAVPGTTIPVAGVNTPHKTASLQGENVTEQMLQYWFLQANPETQKRFLIWAKKQPIH
What are the official names of this protein?
UPF0319 protein YPO1442/y2728/YP_1333.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: COBQ_METCA
Sequence: MSHRLPRGATLMIQGTTSDAGKSTLVTGLCRALHRRGFRVAPFKPQNMALNSAVTPQGGEIGRAQAVQAQACGLPPHTDMNPVLLKPYADQGSQVIIQGHAVGNMDARRYHEFKPTALSAVLESYARLAHQFQAVIVEGAGSPAEINLRTGDIANMGFAEAVDCPVLLVADIDRGGVFAHLVGTLELLSASERERIRGFVINRFRGDMDLLRPGIEWLQRRTGKPVVGVLPHLDGLYLDAEDAVVTKSRPAAPGQDTRLKVIAPRLPRISNHTDFDALRLHPQVDFRFIGTGAPPPPADLVILPGSKSVRADLAWLREAGWEGAIRRHLRYGGKLLGLCGGFQMLGQAIHDPAGLEGPPGSSPGLGLLDFETTLELEKQLRTVSGILILEGATVSGYEIHAGVSSGPALERPACRLERGAEGALSDDGQILGTYVHGLFDEPEALTALLRWAGLPQPRVFDVRLERERGIDRVAAAVEAELNMELIMDLLSGSGRREGHAPAGQP
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: SETB_SALTY
Sequence: MHNSPAAAAPKSFDLTSTAFLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLFAWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCGVMVWFFLPSMRKDAPLATGTLEAPRRNRRDTLLLFVICTLMWGTNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYVGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMPGQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCLARIKDV
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the detoxification of non-metabolizable sugar analogs.  Can transport lactose and glucose (By similarity).
What are the official names of this protein?
Sugar efflux transporter B.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Set transporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ILVE_STAAC
Sequence: MSQAVKVERRETLKQKPNTSQLGFGKYFTDYMLSYDYDADKGWHDLKIVPYGPIEISPAAQGVHYGQSVFEGLKAYKRDGEVALFRPEENFKRLNNSLARLEMPQVDEAELLEGLKQLVDIERDWIPEGEGQSLYIRPFVFATEGALGVGASHQYKLLIILSPSGAYYGGETLKPTKIYVEDEYVRAVRGGVGFAKVAGNYAASLLAQTNANKLGYDQVLWLDGVEQKYIEEVGSMNIFFVENGKVITPELNGSILPGITRKSIIELAKNLGYEVEERRVSIDELFESYDKGELTEVFGSGTAAVISPVGTLRYEDREIVINNNETGEITQKLYDVYTGIQNGTLEDKNGWRVVVPKY
What is the function of this protein?
Acts on leucine, isoleucine and valine.
What are the official names of this protein?
Probable branched-chain-amino-acid aminotransferase, BCAT.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: CXA3_RAT
Sequence: MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEELLRRDNPQHGRGREPMRTGSPRDPPLRDDRGKVRIAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFQLQPLYRCDRWPCPNTVDCFISRPTEKTIFVIFMLAVACASLVLNMLEIYHLGWKKLKQGVTNHFNPDASEVRHKPLDPLSEAANSGPPSVSIGLPPYYTHPACPTVQGKATGFPGAPLLPADFTVVTLNDAQGRGHPVKHCNGHHLTTEQNWASLGAEPQTPASKPSSAASSPHGRKGLTDSSGSSLEESALVVTPEGEQALATTVEMHSPPLVLLDPERSSKSSSGRARPGDLAI
What is the function of this protein?
Structural component of lens fiber gap junctions (Probable).  Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells.  They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity).  Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (Probable).
What are the official names of this protein?
Gap junction alpha-3 protein, Connexin-46, Cx46.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: MDH_ANAPZ
Sequence: MRSHRSVKVSLVGAGNIGGTLAYMLGVAGICQELVFVDVMDGVPRGKLLDIGHALAISGVDITAVGGSDYAAIEGSDAIVVTAGLPRKEGMSREDLLMANAAVIKGVAENIRKYSPDAFVIVVTNPLDAMVWYMHQCSGLPVNKVVGMAGVLDSARFSFFLAKHMSVSVSSVSSVVLGGHGDLMLPLLKYSTVGGVSVSDLISCGRLSSEDVHAIIERTRKGGEEIVKLLKSGSAYYAPAASCMNMLESYLFDKRCVIPCSVGLDGKYGVNGGLFVGVPAVIGKNGVEEVIEYVLSQEEREIFEKSVGLISNSVKIISEQK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: CAPZB_PONAB
Sequence: MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.  Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).  Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit beta, CapZ beta.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.
Protein: METE_STAAR
Sequence: MTTIKTSNLGFPRLGRKREWKKAIESYWAKKISKEELDQTLTDLHKENLLLQKYYHLDSIPVGDFSLYDHILDTSLLFNIIPERFQGRTIDDDLLFDIARGNKDHVASALIKWFNTNYHYIVPEWDNVEPKVSRNVLLDRFKYAQSLNVNAHPVIVGPITFVKLSKGGHQTFEEKVKTLLPLYKEVFESLIDAGAEYIQVDEPILVTDDSESYENITREAYDYFEKAGVAKKLVIQTYFERAHLKFLSSLPVGGLGLDFVHDNGYNLKQIEAGDFDKSKTLYAGIIDGRNVWASDIEAKKVLIDKLLAHTNELVIQPSSSLLHVPVSLDDETLDTSVGEGLSFATEKLDELDALRRLFNQNDSVKYDKLKARYERFQNQSFKNLDYDFESVRTSRQSPFAQRIEQQQKRLNLPDLPTTTIGSFPQSREVRKYRADWKNKRITDEAYETFLKNEIARWIKIQEDIGLDVLVHGEFERNDMVEFFGEKLQGFLVTKFGWVQSYGSRAVKPPIIYGDVKWTAPLTVDETVYAQSLTDKPVKGMLTGPVTILNWSFERVDLPRKVVQDQIALAINEEVLALEAAGIKVIQVDEPALREGLPLRSEYHEQYLKDAVLSFKLATSSVRDETQIHTHMCYSQFGQIIHAIHDLDADVISIETSRSHGDLIKDFEDINYDLGIGLGVYDIHSPRIPTKEEITTAINRSLQQIDRSLFWVNPDCGLKTRKEEEVKDALTVLVNAVKAKRQE
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: MIA40_EMENI
Sequence: MFRPASRALLRAPTPAVGVARGPTRRFISSSTGSTKPRSWKNTFIRVGLASGAVYYYNTSSVFAETPSLSFRPEAQPKHEDGKSLPTLDSIKPKSREEKKAPAAAADAAATPASTGANAQSESPLKSAEELEAEADQQAAFNPETGEINWDCPCLGGMAYGPCGEEFRAAFSCFVYSEEEPKGMDCIDKFKAMQDCFRAHPDVYGAELDDDEEAGAEANAAGVEQPLAAEVDASVPVEKHEQAKEVRDEVKSAAGEVAESEEVVPKALDVSEQEKTPEQQTEK
What is the function of this protein?
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS).  Forms a redox cycle with ERV1 that involves a disulfide relay system.  Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.  The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
What are the official names of this protein?
Mitochondrial intermembrane space import and assembly protein 40, Mitochondrial import inner membrane translocase TIM40.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side.
Protein: NEUA_STRA1
Sequence: MKPICIIPARSGSKGLPDKNMLFLAGKPMIFHTIDAAIESGMFDKKDIFVSTDSELYREICLERGISVVMRKPELSTDQATSYDMLKDFLSDYEDNQEFVLLQVTSPLRKSWHIKEAMEYYSSHDVDNVVSFSEVEKHPGLFTTLSDKGYAIDMVGADKGYRRQDLQPLYYPNGAIFISNKETYLREKSFFTSRTYAYQMAKEFSLDVDTRDDFIHVIGHLFFDYAIREKENKVFYKEGYSRLFNREASKIILGDSKTISISLENYHNYSQGGVTLATMLENLPNFLTANVTEAFVSIGVNDLITGYSVEEIFSNFQKLYSLLAENKIKMRFTTIAYTLFRETVNNADIEKINQWLTEFCYQNQIPLLDINRFLSKDGNLNYHLTSDGLHFTQEANDLLQSQYQLFVDEVKTL
What is the function of this protein?
Catalyzes the formation of CMP-N-acetylneuraminic acid (CMP-NeuNAc), which is essential for the formation of the capsule.
What are the official names of this protein?
N-acylneuraminate cytidylyltransferase, CMP-N-acetylneuraminic acid synthase, CMP-NeuNAc synthase, CMP-sialic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CMP-NeuNAc synthase family.
What are the subcellular locations of this protein?
Cytoplasm.