PharMolix/UniProtQA huggingface dataset:
Protein: Y655_STAA3
Sequence: MGRKWNNIKEKKAQKDKNTSRIYAKFGKEIYVAAKSGEPNPESNQALRLVLERAKTYSVPNHIIEKAIDKAKGAGDENFDHLRYEGFGPSGSMLIVDALTNNVNRTASDVRAAFGKNGGNMGVSGSVAYMFDHVATFGIEGKSVDEILETLMEQDVDVNDVIDDNGLTIVYAEPDQFAVVQDALRAAGVEEFKVAEFEMLPQTDIELSEADQVTFEKLIDALEDLEDVQNVFHNVDLK
What are the official names of this protein?
Probable transcriptional regulatory protein SAUSA300_0655.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOJAP_TREPA
Sequence: MSANGAASAVAEALCDARAEDVCVFDVSARCGWADFAVVATVPGLLHGTHRLVCEQAARFGLREVHRKKRGLCEEQWRVLDFGSILVHLMSAQARAFYDLDRLWQDCLVAR
What is the function of this protein?
Functions as a ribosomal silencing factor.  Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8.  Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity).
What are the official names of this protein?
Ribosomal silencing factor RsfS.
What is the protein family that this protein belongs to?
Belongs to the Iojap/RsfS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGST1_BOVIN
Sequence: MANLSQLMENEVFMAFASYTTIVLSKMNFMSTATAFYRLTKKVFANPEDCAGFGKGENAKKYLRTDDRVERVRRAHLNDLENIVPFLGIGLLYSLSGPDLSTAILHFRLFVRARIYHTIAYLTPLPQPNRALAFFIGYGVTLSMAYRLLKSKLYL
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Microsomal glutathione S-transferase 1, Microsomal GST-1.
What is the protein family that this protein belongs to?
Belongs to the MAPEG family.
What are the subcellular locations of this protein?
Microsome. Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MACB_MANSM
Sequence: MNIIEIKELNRYFGEGENTVHVLKNISVNIEKGDFVAIIGQSGSGKSTLMNIIGCLDTATSGSYKIDGKETNELTSDQLSDLRSQKFGFIFQRYNLLSALTAAENVALPAIYAGKSQSERLARAEELLKKLGLDGKEKNKPSELSGGQQQRVSIARALMNGGEIILADEPTGALDSHSGENVLEILRQLHSEGHTIIMVTHDKNIAASANRIIEIKDGEIIDDTQKHPVQNTVNNQSKAKSRFGFSKDQLMEAFQMSVSAIIAHKMRSLLTMLGIIIGITSVVSVVALGNGSQQKILSNISGLGTNTMTIFNGTGFGDRRAEQMQNLTVNDANALAKQSYVQNVTPNSSSSGLLIYGNQSFTSTNLKGIGEQYFDVEGMTLKQGRSITAQEVRDNAQVALLDESSKKSIFPNDNPIDKIVMFAKRPFRIIGVVADRQMGAASSSLNIYAPYTTVMNKVTGGTKIDSITVKIADNVNTAVAEKSLTEYLTVRHGKKDFFIMNSDTIKQTIESTTGTMKLLISSIAFISLIVGGIGVMNIMLVSVTERTKEIGVRMAIGARKSNILQQFLIEAILICMIGGISGIMLSLIIGGIFNVFMTDFTMVFSTFSIVAAVLCSTLIGVIFGYMPAKNAAQLDPITALARE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UCN1_HUMAN
Sequence: MRQAGRAALLAALLLLVQLCPGSSQRSPEAAGVQDPSLRWSPGARNQGGGARALLLLLAERFPRRAGPGRLGLGTAGERPRRDNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK
What is the function of this protein?
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563).  Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563).  Plays a role in the establishment of normal hearing thresholds (By similarity).  Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).
What are the official names of this protein?
Urocortin.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
What are the subcellular locations of this protein?
Secreted.
Protein: GB_ILTVT
Sequence: MQSYIAVNIDMASLKMLICVCVAILIPSTLSQDSHGIAGIIDPRDTASMDVGKISFSEAIGSGAPKEPQIRNRIFACSSPTGASVARLAQPRHCHRHADSTNMTEGIAVVFKQNIAPYVFNVTLYYKHITTVTTWALFSRPQITNEYVTRVPIDYHEIVRIDRSGECSSKATYHKNFMFFEAYDNDEAEKKLPLVPSLLRSTVSKAFHTTNFTKRHQTLGYRTSTSVDCVVEYLQARSVYPYDYFGMATGDTVEISPFYTKNTTGPRRHSVYRDYRFLEIANYQVRDLETGQIRPPKKRNFLTDEQFTIGWDAMEEKESVCTLSKWIEVPEAVRVSYKNSYHFSLKDMTMTFSSGKQPFNISRLHLAECVPTIASEAIDGIFARKYSSTHVRSGDIEYYLGSGGFLIAFQKLMSHGLAEMYLEEAQRQNHLPRGRERRQAAGRRTASLQSGPQGDRITTHSSATFAMLQFAYDKIQAHVNELIGNLLEAWCELQNRQLIVWHEMKKLNPNSLMTSLFGQPVSARLLGDIVAVSKCIEIPIENIRMQDSMRMPGDPTMCYTRPVLIFRYSSSPESQFSANSTENHNLDILGQLGEHNEILQGRNLIEPCMINHRRYFLLGENYLLYEDYTFVRQVNASEIEEVSIFINLNATILEDLDFVPVEVYTREELRDTGTLNYDDVVRYQNIYNKRFRDIDTVIRGDRGDAIFRAIADFFGNTLGEVGKALGTVVMTAAAAVISTVSGIASFLSNPFAALGIGIAVVVSIILGLLAFKYVMNLKSNPVQVLFPGAVPPAGTPPRPSRRYYKDEEEVEEDSDEDDRILATRVLKGLELLHKDEQKARRQKARFSAFAKNMRNLFRRKPRTKEDDYPLLEYPSWAEESEDE
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: NDH_STAAN
Sequence: MAQDRKKVLVLGAGYAGLQTVTKLQKAISTEEAEITLINKNEYHYEATWLHEASAGTLNYEDVLYPVESVLKKDKVNFVQAEVTKIDRDAKKVETNQGIYDFDILVVALGFVSETFGIEGMKDHAFQIENVITARELSRHIEDKFANYAASKEKDDNDLSILVGGAGFTGVEFLGELTDRIPELCSKYGVDQNKVKITCVEAAPKMLPMFSEELVNHAVSYLEDRGVEFKIATPIVACNEKGFVVEVDGEKQQLNAGTSVWAAGVRGSKLMEESFEGVKRGRIVTKQDLTINGYDNIFVIGDCSAFIPAGEERPLPTTAQIAMQQGESVAKNIKRILNGESTEEFEYVDRGTVCSLGSHDGVGMVFGKPIAGKKAAFMKKVIDTRAVFKIGGIGLAFKKGKF
What is the function of this protein?
Alternative, nonproton pumping NADH:quinone oxidoreductase that delivers electrons to the respiratory chain by oxidation of NADH and reduction of quinones, and contributes to the regeneration of NAD(+).
What are the official names of this protein?
Type II NADH:quinone oxidoreductase, NDH-2.
What is the protein family that this protein belongs to?
Belongs to the NADH dehydrogenase family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RF1_STRAG
Sequence: MNIYDQLQPVEDRYEELGELLSDPYVVSDTKRFMELSREEANTRETVTAYREYKQVIQNISDAEEMIKDASGDAELEEMAKEELKESKAAKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDQKDLRADIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILSGKMDEVIDALVMYDQTQKLEALNK
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU1M_BRAFL
Sequence: MILSVIHIFLYFVPVLLAVAFLTLTERKVIGYVQLRKGPNVVGPYGLLQPIADGVKLFIKEPIKPSSSNPSVFFFAPMLALILALLLWMPVPLMDAFIELNFAVLFVLAISSLSVYSIMASGWSSNSKYALLGALRAVAQMVSYEVSLGLIILSLICLVGGFNLAQFFSAQEEVMLMLSCWPLGIMWFISTVAETNRSPFDLTEGESELVSGFNVEYSGGPFALFFLAEYANILFMNVLSALLFLAAHFSLLGVAVKVGLLAGLYLWFRASYPRFRYDQLMHLAWKSFLPLSLGLLMLNFSLPLTFSGIGGGL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CEXY_THEST
Sequence: MNKFLNKKWSLILTMGGIFLMATLSLIFATGKKAFNDQTSAEDIPSLAEAFRDYFPIGAAIEPGYTTGQIAELYKKHVNMLVAENAMKPASLQPTEGNFQWADADRIVQFAKENGMELRFHTLVWHNQTPTGFSLDKEGKPMVEETDPQKREENRKLLLQRLENYIRAVVLRYKDDIKSWDVVNEVIEPNDPGGMRNSPWYQITGTEYIEVAFRATREAGGSDIKLYINDYNTDDPVKRDILYELVKNLLEKGVPIDGVGHQTHIDIYNPPVERIIESIKKFAGLGLDNIITELDMSIYSWNDRSDYGDSIPDYILTLQAKRYQELFDALKENKDIVSAVVFWGISDKYSWLNGFPVKRTNAPLLFDRNFMPKPAFWAIVDPSRLRE
What is the function of this protein?
Active toward xylan, carboxymethylcellulose, P-nitrophenyl-beta-D-xylopyranoside and P-nitrophenyl-beta-D-cellobioside.
What are the official names of this protein?
Thermostable celloxylanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
Protein: ERT1_CANDC
Sequence: MNIEQENITNTTLTNTNNVNDKPKPKRKKTSRACNHCHKAHMTCDPGRPCQRCIQRGLGSTCEDAPRKRKKYLEDVPNSSLMSSHSINSSDHLDSNGVTPMQSTLSLPMPPVQESPFSTSAPTQSQVPAYTPSTVPQRQPSYSPQVASNYSPNHKTYSATLFQHSATSPELMQTVPEYFPELHNQHYQPSANPNQKRRTNFLSTAADLEYSTLSNILQENFGHHTTSNEGTPNSHNFSPALSPHNMPTTDTNAPPPSIQLASNDQRQVTSFNNHTKHSTPSPLNTSQTKLYEDARYPKCDETINQYFLGDTESGKMVVFPDVLTAIENMKNNDPAVYVERNSKSTLSFAMSISHESNSNNGKDGQLFKEPEEIYEKVKKPFSYTPGYHSLIAYLRKRFTKPMLVKMAESMATYRPSFIACTNSLKEHDLIFMEQCFQRTLLTYDNYIKISGTPTIVWRRTGEVAYVGNEFCVLTGWPKEELIGKDKRKFIVELLDDKSVLQYFQVFSRIAFGDFLGATMTECTLLTPNPNVKIRTGCMWTLKRDVFGIPMMIVGNFLPIL
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes (By similarity).
What are the official names of this protein?
Transcription activator of gluconeogenesis ERT1.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DSBD_PECAS
Sequence: MAQRIFTLIFLLWTAVGTPQVAASSFGQKLFGNSTTSRFLPVDGAFAFEFQQQGNQLNLRWDIHPDYYLYRAQIKIEGNGATLGKVELPQGESHNDEFFGQVFILRDRLALAVPIEQAESGATVKVTYQGCADAGFCYPPETRTVPLSQVLATANTDSPINTLSGQTAPPQTTPMPFSPWWALLIGIGVAFTPCVLPMYPLIASLVLGRKEQLTPRRTLLLSMTYVQGMALTYTLLGLIVAAAGLRFQAALQHPYILIGLSVMFIALALSMFGLYTLQLPSSVQTRLTEWSNRQQGGSVTGVFCMGALAGLICSPCTTAPLSAILLYIAQSGNMLAGGGTLYLYALGMGLPLILVTLFGNKLLPRSGPWMQYVKEAFGFIILALPVFLLERILGEAWGIRLWSALGIAFFGWALMLTLSSKKGWMRGVQLLLLAGVVISAKPLQDWVFPPTGTAQTHTSALNFAPVANIADLNSALAKSPQPVMLDLYADWCVACKEFEKYTFSDPAVQNHLSRITLLQADVTANREEQNALLKKLQVLGLPTIVFFDTQGKEIPGSRVTGFMNAEQFQAHLQKFSP
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MATK_PAESU
Sequence: MEKSQGYLELDKSWRHDFLYPLIFQEYIYALAHEQGLNRSILLENTDHDNKYSSLIVKRLITRMQQQNHFLIFDNDSNQNPFWKHNNNLYSQMISEGFVIIVEIPFSPRFVDSLEEKKKILKFNNLRSIHSIFPFLEDQILHLNFVSNILIPYPIHLEIVVQSLRYRVKDASSLHLLRFFLFTLNKSISSFSKRNPRLFLFLYNSHVYEYESTFLFLRNKTSHLRSTSSGAFLERIFFYGKIKHLIEVFANDFQAILWLFKDPFMHYVRYQGKSILASKRTSLRMNKWKYYLINFWQCQFYVWSQPGRVSINQLSNHSLDFLGYLSSVRLNPLAVRSQMLENSFLTDNAIKKFDIIVLLIPLIGSLAKAKFCNVLGHPLSKPARADSSDSDIIERFVRICRNLSHYHSGSSKKKSLYRIKYILRLSCARTLARKHKTAVRSFLKRLGSELLEEFLTEDGQVISLIFPRTSSTSWRLYRGGIWYLDITCINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS4_ECOL6
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
Also functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis.  Binds directly to RNA polymerase (By similarity).
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: AKAP8_CANLF
Sequence: MEQGYGGYGAWSAGPTNTQGAYGTGVASWQGYENYNYYGAQNTSVTTGASYSYGPASWETTKASDSLGAGGPAVHMASYGPEPCTDNSDSLIAKINQRLDMMSKEGGRGGSSGGGEGMQDRESSFRFQSYESYDSRSCLPEHHPYRPSYSYDYDFDPMPDRNGGFSSQYGDCRDPARERGSLDGFMRGRGQGQGQGRFQDRSNPSTFMRSDPFMPPSASSEPLSAPWPELNYVGGRGLGGPSPSRPPPSLFSQSMAPDFGVMGMQGAGGYDNSVPYGCGRSQTRMRDRPRRRGFDRCGPDGMGRKRKQLQIYDEPDAKLARADSEGDFSENDDGAADFRSGDEEFRGEDEFFDPGRQRGEKDDEDDEVKKRREKQRRRDRMRDRAADRIQFACSVCKFRSFEDEEIQKHLQSKFHKETLRFISTKLPDKTVEFLQEYIVNRNKKIEKRRQELMEKESTKPKPDPFKGIGQEHFFKKIEAAHCLACDMLIPAQHQLLQRHLHSVDHNHNRRLAAEQFKKTSLHVARSVLNNRHIVKMLEKYLKGEDPFTSEAVDPEIEGDDTLGGEKEETPEEVAAEVLAEVITAAVRAVDGEGAPAPEGSDTPPEGQGPVDTAEATHSPHSEQLVEVETPCGAAPEKGDANAEAGGETTEAAGEEQEVVAKTDGAVDGTVRGAAPAPPVTETKAEQTEAEPKDVTPTE
What is the function of this protein?
Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).  Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis.  Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring.  May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression.  Required for cell cycle G2/M transition and histone deacetylation during mitosis.  In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L.  Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation.  May be involved in regulation of DNA replication by acting as scaffold for MCM2.  Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation.  In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation.  May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells.  May act as a carrier protein of GJA1 for its transport to the nucleus.  May play a repressive role in the regulation of rDNA transcription.  Preferentially binds GC-rich DNA in vitro.  In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions.  Involved in modulation of Toll-like receptor signaling.  Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity).
What are the official names of this protein?
A-kinase anchor protein 8, AKAP-8, A-kinase anchor protein 95 kDa, AKAP 95.
What is the protein family that this protein belongs to?
Belongs to the AKAP95 family.
What are the subcellular locations of this protein?
Nucleus matrix. Nucleus, nucleolus. Cytoplasm. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis. Exhibits partial localization to the nucleolus in interphase, possibly to the fibrillary center and/or to the dense fibrillary component (By similarity).
Protein: HSLV_SINMW
Sequence: MSEHNPYGTMHATTIITVRKGGKVVMAGDGQVSLGQTVMKGNARKVRRLSKGDVIAGFAGATADAFTLLERLEVKLEQYPDQLMRAAVELAKDWRTNKYLRNLEAMMLVADRSVTLAITGNGDVLEPEHGTIAIGSGGNYAFAAARALMDTDRSAEEIARRALEIAGDICVYTNHNVVLETLDAE
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCD1_YEAST
Sequence: MANNTWKLIATTALISVFSTQLAKSVWKEYKLSCAANKNKTVSRPRQYDDHLFREQLARNYAFLGEEGMRKIKEQYIVIVGAGEVGSWVCTMLIRSGCQKIMIIDPENISIDSLNTHCCAVLSDIGKPKVQCLKEHLSKIAPWSEIKARAKAWTKENSHDLIFADGESPTFIVDCLDNLESKVDLLEYAHHNKIDVISSMGVATKSDPTRVSINDISMTEFDPISRCVRRKLRKRGIATGISVVFSNEMLDPRRDDILSPIDCEHRAINAVRDEALRHLPELGTMPGIFGLSIATWILTKVSGYPMKENEVKNRLKFYDSILETFQKQMARLNENKERSSLLGLEEVGYIVEEMFRGKSPISGYSTKLALTKWEANKEISLTNVVLMTKEEQEIHEKRILLDGEKLTAVYSEEVLDFIERLFKEEEYYS
What is the function of this protein?
Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
What are the official names of this protein?
tRNA threonylcarbamoyladenosine dehydratase 1, t(6)A37 dehydratase 1.
What is the protein family that this protein belongs to?
Belongs to the HesA/MoeB/ThiF family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: NDUS2_NYCOV
Sequence: MMRSSSLQKNIMLLRVGSKDSTRFRILILNFGPQHPASHGVLRLVIVIIGEVVTKLDPHIGFLHRGTERLVEEHSYMNAAVFMDRLDYTTVLTQTHAYCLAVEQALAKSRLCIRTQLLRTIFDELSRILNHLLSIATHALDIGTMAMLFWAFEDRERIMELYEYISGARMHTALYYPNQTLDHILTNELLAKILIFSRNSEKTYTEIYIALYNNRVWRLRLCGIGVVSTEISTSTTISGPVARSTGLQLDMRSGENYQYGYYASLTLRIFLGISGDSFDRFIIRLRELFESTRLIYNSLIELSAYINISVYNMCSYSNNPHLKIESLIELFRYSLGEYLLNISLVSGFVESGKGIFGIMLAANNTNRPYRLYIRSPAYMHLQLLPKLGAGHHIADLATLLGSIDVVFGEVDR
What is the function of this protein?
Transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.  Component of the iron-sulfur (IP) fragment of the enzyme.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 49 kDa subunit, NADH dehydrogenase subunit 7.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Hydrogenosome.
Protein: IL2_SAISC
Sequence: MYRMQLLSCIALSLALITNSAPTSSSTKKTQLQLEHLLLDLQMLLNGINNYKNPKLTRMLTFKFYLPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRDTRDIISNINVLVLELKGSETTFTCEYDDDTATIIEFLNGWITFCQSIISTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LNT_PSEA8
Sequence: MRWISRPGWPGHLLALAAGALTPLALAPFDYWPLAILSIALLYLGLRGLPGKSALWRGWWYGFGAFGAGTSWIYVSIHDYGAASVPLASLLMLGFTAGVAFFFALPAWLWARCLRRDNAPLGDALAFAALWLALELFRSWFLTGFPWLYAGYSQLQGPLAGLVPVGGVWLSSFVIALSAALLVNLPRLFPHGASLLLGLVLLLGPWAAGLYLKGHAWTHSAGEPLRVVAIQGNIAQELKWDPNQVRAQLDLYRDLSLPQQDVDLIVWPETAVPILQDMASGYLGAMGQVADEKNAALITGVPVRERLTDGKSRYFNGITVVGEGAGTYLKQKLVPFGEYVPLQDLLRGLIAFFDLPMSDFARGPADQPLLKAKGYEIAPYICYEVVYPEFAAALAAQSQVLLTVSNDTWFGTSIGPLQHLQMAQMRALESGRWMIRATNNGVTGLIDPYGRIVRQIPQFQQGILRGEVIPMQGLTPYLQYRVWPLAGLAGVLLLWALLGRQLRPQERRLFG
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BCHL_BRASB
Sequence: MNVTLRPPLTTAPRRPDGAGSVQVQLDPNVVIGTAKVFSVYGKGGIGKSTTSSNLSVALSKLGKRVLQIGCDPKHDSTFTLTKRLVPTVIDILEQVNFHAEELRPEDFVYQGYNGVMCVEAGGPPAGTGCGGYVVGQTVKLLKEHHLLEDTDVVIFDVLGDVVCGGFAAPLQHADRALIVAANDFDSIFAMNRIVAAIQAKSRNYPVRLGGVIANRSAATDQIDKFNERAGLKTVAHFPDLDVIRKSRLKKCTLFEMEPSPDVERAQNEYLRLAASLLAGVEPMQAVPLKDRDIFDLLGFD
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: TRUA_MYCPA
Sequence: MAGVLDEALTTVFRTPVRLRAAGRTDAGVHATGQVAHLDVPGTALPNAYPRAPHVGEAEFGPLLRRLGRFLPTDVRVVDITRAPAGFDARFSALRRHYVYRLSTAPWGVLPQQARYVTAWPRPLDVEAMAAASRDLLGLHDFAAFCRHRENATTIRDLQRLDWTRDGDLITARVSADAFCWSMVRSLVGALLAVGENRRPVSWCRELLSATNRSSDYATAPAHGLTLVGVDYPPDDQLAARNLITRDVRSR
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.