PharMolix/UniProtQA huggingface dataset:
Protein: IMDH_MYCLE
Sequence: MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDVLLLPAASDVVPATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIAMARAGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVVDDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTEQHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: RHAS_YERPP
Sequence: MTVLHSIDFFSSSSAPVAIEARAPQSAFPEHHHDFYEIVIVEEGAGVHVFNGNPYTLSRGCVCFVRDHDRHLFESTDDLFLTNVLFRAPDAFRFLSGVGHFLPRECDGVYPSHWRVNGQVLQQIKCLIACLEHAPKSDQVEDIALHESVFMQLLVKLWQGCQTQAGDDQEGRLYQLLDWLQNNYSEAVEWPELADRFALPLRTLHRQLKNKTGMTPQRYLTRLRLLQARHQLCYSDNSVTDIAYLCGFGDSNHFSTLFKREFSQSPRDLRSQL
What is the function of this protein?
Activates expression of the rhaBAD and rhaT operons.
What are the official names of this protein?
HTH-type transcriptional activator RhaS, L-rhamnose operon regulatory protein RhaS.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_VESOH
Sequence: MAHKKAGGSTNNGRDSVSKRLGVKRFGGQVVLAGNILVRQRGTKFHPGTNVRKGKDDTLFATMDGRVVFSKKGKFMYQYISIEIT
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: ARGJ_COPC7
Sequence: MSAPFIFKRFSSTIPIHSKPTPSKAHLHFPLPSSSFPKGYVLTGIHAGVKKVAGVPDLAVILSTSSQPTSAAACFTRNAFKAAPVIVSNEILKKNGGYARGVVVNSGCANAVTGKQGMEDAWAMVRETDALLPSKKFEHETLVMSTGVIGQNLPISKIVEGIRSQAESSSTRSLASDFSAWERAAKAFMTTDTFPKLRSRTFTIDGVEYKLAGMDKGAGMIHPDMGPAGTEFKKQLHATLLGCILTDAAVSPRSLQSALTYAVDRSFNSISVDGDMSTNDSIYVLANGAASSSIIDEDATPQAYEAFKQELTTFAADLAKLVVRDGEGATKFVTVTVKGAPSYKDAHSIASRISTSALVKTALYGEDANWGRILAATGSVPLSPTNANTPPPVIDTTKVCVTIVPADGTAPLPVLVNGEPENVDEDRAKEIMTQEDFELLVDLGGMGDGEAQYWTCDFSYEYVRINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: HMDH_SCHPO
Sequence: MIYKLAARYPIQVIAIVGILVSMAYFSFLEALTQEDFPVLIRALKRFGILDGFPNTRLPNEMILKLSSVQGEDASVWEQIPAAELGGEGFVDFDITQWYYPANAKVDVAQLVEPYRNDCIFHDASGACHFFFKEVGNWTVSSIALPSNLANPPIDYFLDSSSTVIQRILPAIREHGISWSWLLQLIARTWMNTLKIASQASKTELLIVGTAYACMLISIVSLYLKMRRLGSKFWLFFSVLLSTLFSVQFAMTLVRASGVRISLVSLIESLPFLINVVALDKAAELTRQVITRCSVSDSHSPMHEDIAKACRNAAPPILRHFSFGIVVLAIFSYCNFGIKQFFLFAAVMIYDLLLLFSFFVAILTLKLEMRRYNAKDDVRKVLIEEGLSESTARHVADGNDSSATTSAGSRYFKVRYGTKIILFIFIAFNLFELCSIPFKHYAATSAAAARLIPLVRSQYPDFKSQRLLDDGVFDDVLSAISSMSNIESPSVRLLPAVFYGAELSSTSFLSTIHSFINNWSHYISASFLSKWIVCALSLSIAVNVFLLNAARLNSIKEEPEKKVVEKVVEVVKYIPSSNSSSIDDIQKDEIAQESVVRSLEECITLYNNGQISTLNDEEVVQLTLAKKIPLYALERVLKDVTRAVVIRRTVVSRSSRTKTLESSNCPVYHYDYSRVLNACCENVIGYMPLPLGVAGPLIIDGKPFYIPMATTEGALVASTMRGCKAINAGGGAVTVLTRDQMSRGPCVAFPNLTRAGRAKIWLDSPEGQEVMKKAFNSTSRFARLQHIKTALAGTRLFIRFCTSTGDAMGMNMISKGVEHALVVMSNDAGFDDMQVISVSGNYCTDKKPAAINWIDGRGKSVIAEAIIPGDAVKSVLKTTVEDLVKLNVDKNLIGSAMAGSVGGFNAHAANIVTAVYLATGQDPAQNVESSNCITLMDNVDGNLQLSVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGAHMTSPGDNSRQLARVVAAAVMAGELSLCSALASGHLVKSHIGLNRSALNTPAMDSSAKKPATDALKSVNSRVPGR
What is the function of this protein?
Part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:8896278, PubMed:19486165).  Hmg1 catalyzes the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate (PubMed:8896278, PubMed:19486165).  The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase eg10 that catalyzes the formation of acetoacetyl-CoA.  The hydroxymethylglutaryl-CoA synthases erg13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.  The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases hcs1 (Probable).
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.
Protein: DAPH_CLOBL
Sequence: MSYNLTDPYEIARYIKEAKKSTPIKAYIEGDLSNCDFTNIEKFNSGDLYILFGESEEILVIIENNKDKIKNCRIEQDRRKSAIPLLDMLKVNARIEPGAIIRDKVLIGENAVIMMGAVINIGAEIGEGTMVDMNAVVGARGKLGKNVHLGAGAVVAGVLEPPSSDPCTIEDNVLIGANAVILEGIKIGKGSVVAAGSIVTTDVPENVVVAGAPAKIIKEVDVKTKDKTKLLDDLRK
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: DRL38_ARATH
Sequence: MGNNFSVESPSLAPFLCGKRKYLYNLERNLEALHKVMQDLNAMRNDLLKRLSKEEEIGLQGLQEVKEWISMVEEIEPKANRLLDESVSEIQRLSRYGYCSLIPASTYRYSEKVLTTMEGVETLRSKGVFEAVVHRALPPLVIKMPPIQLTVSQAKLLDTAWARLMDINVGTLGIYGRGGVGKTTLLTKLRNKLLVDAFGLVIFVVVGFEEVESIQDEIGKRLGLQWRRETKERKAAEILAVLKEKRFVLLLDGIQRELDLEEIGVPFPSRDNGCKIVFTTQSLEACDESKWVDAKVEITCLSPEEAWDLFQETVGENTLRSHQDIPKLARVVASTCRGLPLALNLIGEAMSGKRTVREWRYTIHVLASSTAEFPDMEDGTLPILKSIYDNMSDEIIRLCFLYCALFPENLDIGKEDLVNYWICEGILAKEDREEAEIQGYEIICDLVRMRLLMESGNGNCVKMHGMVREMALWIASEHFVVVGGERIHQMLNVNDWRMIRRMSVTSTQIQNISDSPQCSELTTLVFRRNRHLKWISGAFFQWMTGLVVLDLSFNRELAELPEEVSSLVLLRFLNLSWTCIKGLPLGLKELKSLIHLDLDYTSNLQEVDVIASLLNLQVLRLFHSVSMDLKLMEDIQLLKSLKELSLTVRGSSVLQRLLSIQRLASSIRRLHLTETTIVDGGILSLNAIFSLCELDILGCNILEITIDWRCTIQREIIPQFQNIRTMTIHRCEYLRDLTWLLLAPCLGELSVSECPQMEEVISKDKAMAKLGNTSEQPFQNLTKLVLDGLPKLESIYWTPLPFPVLEYLVIRRCPELRRLPFNSESTIGNQVETIIEEQVIKIVEWEDEATKQRFSHFNNRDFVQMAEDPKMDGLTSESHPIQTIDLVGTTGSGETATANNIQGKKVVQSGTHATVVTMECQTYKVFTPDCPINNMIDTPGTNFLLCYT
What is the function of this protein?
Potential disease resistance protein.
What are the official names of this protein?
Probable disease resistance protein At5g47260.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
Protein: IF1_ALKMQ
Sequence: MSKEDVIEVEGVIKEALPNATFQVELENGHVVLAHLSGKLRMHFIRILPGDKVTVELSPYDLTRGRITWRKK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIN2_ARATH
Sequence: MGIKYLPVSVASTALSFVGLQVWTELSLDRLRADGLIAKNISLGDSEHALELLLGSYFTIALLTNFVLNVYILLVLSLKTLFFGDLYDVETKKLVERLANYIIYKGTFLPLVIPPTIFQGVLWTVWLTVLCTLKMFQALARDRLERLNASPSSTPWTYFRVYSVLFLVLSVDMFWIKLSLMTYNTIGSAVYLLLLFEPCSIAFETLQALLIHGFQLLDMWINHLAVKNSDCQRSKFIDSMTAGSLLEWKGLLNRNLGFFLDMATLVMALGHYLHIWWLHGIAFHLVDAVLFLNIRALLSAILKRIKGYIKLRIALGALHAALPDATSEELRAYDDECAICREPMAKAKRLHCNHLFHLGCLRSWLDQGLNEVYSCPTCRKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQDLQRTNSVAVTVNNLLQM
What is the function of this protein?
E3 ubiquitin protein ligase that acts as positive regulator of RPM1- and RPS2-dependent hypersensitive response (HR), in association with RIN3.  Probably not required for RPM1 degradation during HR.
What are the official names of this protein?
E3 ubiquitin protein ligase RIN2, AMF receptor-like protein 1A, RING-type E3 ubiquitin transferase RIN2, RPM1-interacting protein 2.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: FGFR4_HUMAN
Sequence: MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.  Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.  Phosphorylates PLCG1 and FRS2.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation.  FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4.  Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
What are the official names of this protein?
Fibroblast growth factor receptor 4, FGFR-4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane. SUBCELLULAR LOCATION: [Isoform 2]: Secreted. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Protein: Y1286_BACAA
Sequence: MQNKIQVKSVEKRENALIFCAENSEIEVKGLSARNHVLVDSDNLSFLYILENESSFIYVSIPHTCWEAMNNDVVMFVRVNDIEMELEGLKEEVEYLVENIEGNANYGEELVTAVEKVFL
What are the official names of this protein?
UPF0738 protein BAA_1286.
What is the protein family that this protein belongs to?
Belongs to the UPF0738 family.
Protein: ATP6_ECOHS
Sequence: MASENMTPQDYIGHHLNNLQLDLRTFSLVDPQNPPATFWTINIDSMFFSVVLGLLFLVLFRSVAKKATSGVPGKFQTAIELVIGFVNGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHVLGLPALRVVPSADVNVTLSMALGVFILILFYSIKMKGIGGFTKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCNC_DROME
Sequence: MAGNFWQSSHSQQWILDKPDLLRERQHDLLALNEDEYQKVFIFFANVIQVLGEQLKLRQQVIATATVYFKRFYARNSLKNIDPLLLAPTCILLASKVEEFGVISNSRLISICQSAIKTKFSYAYAQEFPYRTNHILECEFYLLENLDCCLIVYQPYRPLLQLVQDMGQEDQLLTLSWRIVNDSLRTDVCLLYPPYQIAIACLQIACVILQKDATKQWFAELNVDLDKVQEIVRAIVNLYELWKDWKEKDEIQMLLSKIPKPKPPPQR
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Binds to and activates cyclin-dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.  Required for leg and eye development and macrochaete specification or differentiation.
What are the official names of this protein?
Cyclin-C.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
Protein: EFTS_LISIN
Sequence: MANITAQMVKELREKTGAGMMDCKKALVETEGDMEKAIDYLREKGIAKAAKKSDRVASEGMTHVISNEKHAVVLEVNAETDFVAKNDNFQQLVDALAKQILEVRPDSLEDALKTEMPNGQTVQDYITEAITKIGENISLRRFEVKEKADNSAFGEYIHMNGRIGVLTLLEGTTDTTVAKDVAMHIAAINPKYISREDVSTEEVEHEKEVLTQQALNEGKPANIVEKMVEGRLKKYLSEISLEDQPFVKNPDITVGEYVKQSGGKVVSFVRFEVGEGIEKKEDNFVEEVMSQVKK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP4_ROTAM
Sequence: MDKLADLNYTLSVITLMNDTLHSIIQDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVIKCCIVTIINTLLKLAGYKEQVTTKDEIEQQMDRIIKEMRRQLEMIDKLTTREIEQVELLKRIHDNLIIKPVDVIDMSKEFNQKNIKTLDEWESGKNPYEPLEVTASM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: URK_CLOP1
Sequence: MKRPIFIGITGGTGSGKSTIAKEIYRQFGEDCIAMIEQDSYYKDQSHLSMEDRVKTNYDHPNAFDNNLLVSHLESLLNGHSIQKPSYDFSIHNRIEDTTKVEPKEIVIVEGILILEDPRIRELLDIKIYVDTDADVRIIRRMVRDINERGRTMESVINQYLNVVKPMHNQFTEPTKKFADIIIPEGGHNKVAIDIIVAKIKEVLGKYE
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLPA_META3
Sequence: MEKVKLKEIFNNIYELKSDDGLKRIATKSLVPSKRIYGEKLITGEDNLEYRIWNPNRSKLGAAIVNGLKTMPIKKGSKVLYLGVSAGTTPSHVADITENSPVYSVEFAPRIMREFLDVSKDRKNLIPILGDATNPVEYSNVVEEVDVIFEDVAQPKQAEILVNNAKWFLKEGGYGMISIKARSVDVLRNPKEIFEEQKQILIEGGFEIVDEVNIEPFEKDHILFVGIWNKQ
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: FXYD6_BOVIN
Sequence: MEVVLLFLCGLLAPAVLASATEQEKEKDPFHYDYQTLRIGGLVFAVVLFSVGILLILSRRCKCSFNQKPRAPGDEEAQVENLVTANATEPQKAEN
What are the official names of this protein?
FXYD domain-containing ion transport regulator 6, Phosphohippolin.
What is the protein family that this protein belongs to?
Belongs to the FXYD family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HCAC_ECOLI
Sequence: MNRIYACPVADVPEGEALRIDTSPVIALFNVGGEFYAINDRCSHGNASMSEGYLEDDATVECPLHAASFCLKTGKALCLPATDPLTTYPVHVEGGDIFIDLPEAQP
What is the function of this protein?
Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.  This protein seems to be a 2Fe-2S ferredoxin.
What are the official names of this protein?
3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin component family.
Protein: DHQS_METPE
Sequence: MKQCWVDLSCWNKDLATVALEAGVDAIVVDDAAKVNVLAKVTTIAPNGDLIPGKDVSMVTIVDKASEEACLEKAKLGPVIVSTGDWTVIPLENLVAQSDRIFAAVGSVEEARLALTILEQGVAGVVLMTTDPEVIRTVAAMVRGAGAKVPLVPFTLTVVRQLGMGDRVCIDTCSILADGEGMLVGNTSSAFFLVHAETIENLYVAPRPFRVNAGAVHAYVLTPGNRTAYLADLRAGDLVTVTAADGGTEEVIIGRLKIEKRPLLLVEGEAGGVKAGLVLQNAETIRLVGLDGKARSVVDLKPGDQVLGMVAEGGRHFGYAVKEQICEQ
What is the function of this protein?
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
What are the official names of this protein?
3-dehydroquinate synthase, DHQ synthase, 3-dehydroquinate synthase II.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type DHQ synthase family.
Protein: RS28_PYRAE
Sequence: MAEEVKFSPYEDAVAGLVVQILGRTGIAGEVTQVKIKILEGRDKGRVLTRNVKGPVRLGDIVMLRETEREARRITAR
What are the official names of this protein?
30S ribosomal protein S28e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS28 family.
Protein: AZO1_STAAS
Sequence: MKGLIIIGSAQVNSHTSALARYLTEHFKTHDIEAEIFDLAEKPLNQLDFSGTTPSIDEIKQNMKDLKEKAMAADFLILGTPNYHGSYSGILKNALDHLNMDYFKMKPVGLIGNSGGIVSSEPLSHLRVIVRSLLGIAVPTQIATHDSDFAKNEDGSYYLNDSEFQLRARLFVDQIVSFVNNSPYEHLK
What is the function of this protein?
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines.  Requires NADPH, but not NADH, as an electron donor for its activity (By similarity).
What are the official names of this protein?
FMN-dependent NADPH-azoreductase, NADPH-dependent flavo-azoreductase, NADPH-flavin azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 2 family.
Protein: DAPH_LISMF
Sequence: MEQMDAHQIISFIQNSKKATPVKVYLKGDLEKIDFPSDVKTFITGNAGTIFGEWAVVEPFLEANKANIEDYVIENDRRNSAIPLLDMKNINARIEPGAVIRDQVTIGDNAVIMMGASINIGSVIGDGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVVEPPSAQPVVVEDNVVVGANVVVLEGVRIGEGAVVAAGAIVTKDVAPGTVVAGIPARELKKLDAKTASKTEIMQELRQL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: MAOC_SOLLC
Sequence: IRHESTVTGGVQDVYGEDSATEDQSITPWTLSVASGFSLLRNPHYNKGLAFSERERDTHYLRGLLPPVVISHDLQVKKMMNSIRKYDVPLQRYMAMMDLQEMNERLFYKLLIDNVEELLPIVYTPTVGEACQKYGWIFKRPQGLFFSLKEKGKIHEVLKNWPEKKIQVIVVTDGERILGLGDLGCQGMGIPVGKLSLYSALGGIRPSACLPVTIDVGQTMKFVDDEFYIGLRQRRATGQEYSELLDEFMYAVKQNYGEKVLIQFEDFANHNAFNLLAKYGTSHLVFNDDIQGTASVVLAGLMAALNLVGGSLSEHTFLFLGAGEAGTGIAELIALEMSKQTGIPLEETRKKIWMVDSKGLIVKSRMEMLQHFKRPWAHDHEPVQELVNAVKSIKPTVLIGSSGAGRTFTKEVVQAMATFNEKPIIFALSNPTSQSECTAEEAYSWSEGRAIFASGSPFAPVEYNGKVYASGQANNAYIFPGFGLGLIISGAIRVHDDMLLVASEALADEVSQENFEKGTHIPPFSNIRKISAHIAKVAAKAYELGLATRLPQPKDLVAYAESCMYSPAYRSYR
What is the function of this protein?
The chloroplastic ME isoform decarboxylates malate shuttled from neighboring mesophyll cells.  The CO(2) released is then refixed by ribulose-bisphosphate carboxylase.  This pathway eliminates the photorespiratory loss of CO(2) that occurs in most plants.
What are the official names of this protein?
NADP-dependent malic enzyme, chloroplastic, NADP-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TNR18_MOUSE
Sequence: MGAWAMLYGVSMLCVLDLGQPSVVEEPGCGPGKVQNGSGNNTRCCSLYAPGKEDCPKERCICVTPEYHCGDPQCKICKHYPCQPGQRVESQGDIVFGFRCVACAMGTFSAGRDGHCRLWTNCSQFGFLTMFPGNKTHNAVCIPEPLPTEQYGHLTVIFLVMAACIFFLTTVQLGLHIWQLRRQHMCPRETQPFAEVQLSAEDACSFQFPEEERGEQTEEKCHLGGRWP
What is the function of this protein?
Receptor for TNFSF18.  Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.  Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein.
What are the subcellular locations of this protein?
[Isoform A]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform B]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform C]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform D]: Secreted.