PharMolix/UniProtQA huggingface dataset:
Protein: STK11_HUMAN
Sequence: MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQQ
What is the function of this protein?
Has a role in spermiogenesis.
What are the official names of this protein?
Serine/threonine-protein kinase STK11, Liver kinase B1, LKB1, hLKB1, Renal carcinoma antigen NY-REN-19.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Membrane. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Note=Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
Protein: QUAI_DROME
Sequence: MELSLSPKETEIRPNTIPDLKVDATFRKVAKHAITFAIWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYDVRSGALISAPQRPRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWVQKHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADYNSNKFRIYKCNQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRGHKPVSTKFGKLDAHSLCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVKYSVQCATVVPADLASVGIKTIIYQWNGSEASVESISRADKFAKASFDGLKEPGMFVQLYEFDEPPHFLQIFEGKLIIRRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVEETHLSSISSKDCYVIKTNHVWVWCGQSSTGDAREMAKAVGALMGENSLVLEGKESKEFWQSVAMYFNQTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYEEILGFDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAIAQSYVQNAPFGRRSATALAVVRQFQEPNVFKGFFESWQNDYGKNFHSYEKMRKDLGNKVTSNCCFASEGSALILNNRQKDFDGHKKYPLTVLIQEMDMLPPDINPLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQFKLF
What is the function of this protein?
Required for the formation of cytoplasmic actin filament bundles in nurse cells, possibly by regulating both the polymerization and organization of actin filaments.  Mutations in quail result in female sterility due to the disruption of cytoplasmic transport from the nurse cells into the oocyte late in oogenesis.
What are the official names of this protein?
Villin-like protein quail.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
Protein: BIOD_LYSSH
Sequence: MQHFWVVGTDTDVGKTFVTTLLMRNLQKQGVRVTPYKPVQTGEVYDGEQAYYFDTAMYEKYSLQLLDRENLNGYSFKEAASPHFAAQLEGQQIDTQQLLKQMQLLQQTWDVVICEGAGGLFVPLDACGETTLLDVIVESKLPVVVVTRTALGTINHTLLTLEALTTRKIEVLGLVFNGDMGSRMEQDNIQTILQYYTLPYMTIPKLEELSDINEYAITGTSLFERLIRRETSIN
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMT12_ARATH
Sequence: MAGFTMSLNLLLLVAMVATNILSLYHLSSTTNFFQSTVKSSQSSVPTVPDHLLRQLHTIRAAINHLTTHQPDKSTSTSTSRAAVSSSSSSTAPKELLIYSKLSPIASACHNYPDLLHEYMNYTPFSLCPSDTDLVEKLILRGCHPLPRRRCFSRTPRNPSDSKPESNVLWSYYSCKSFDCLITKFSDLGFDLSLEKSKSQFSAYKSELDLPISQLLQIAKSANSVLRLGIDVGGGTGSFAAAMKARNVTVLTTTMNFNAPYSEAVAMRGLVPLHVPLQQRLPVFDGVVDLVRCGRAVNRWIPVTVMEFFFFDLDRILRGGGYLWLDRFFSKKVDLENVYAPMIGKLGYKKVKWAVANKADSKHGEVFLTALLQKPVAR
What are the official names of this protein?
Probable methyltransferase At1g29790.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: LDH_STRA3
Sequence: MTATKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPALFDKAVGDAEDLSHALAFTSPKKIYAATYADCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFNGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALADKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVQLEQWLQENRDIDEQGLVDLFISVRDAAYSIINKKGATYYGIAVALARITKAILDDENAVLPLSVYQEGQYGDVKDVFIGQPAIVGAHGIVRPVNIPLNDAELQKMQASAEQLKDIIDEAWKNPEFQEASKN
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_ERYLH
Sequence: MNTIQPDDWAMHDTGAAPTAEVEGAVAAPVPIEGIRGKLTNQAPLAKLVWFKSGGAADWLFEPADLDDLKTFLARLDGDLPVMALGLGSNLIIRDGGVPGVVIKLGKAFASVETHDDYTVTCGAGAHGVLVASTARDAGIAGLEFMRGIPGTIGGFVRMNAGAYGRETRDVLIDCDVVLPGGSFVTLPVADLQYTYRHSALPDGAVVVSARLQGEPGDPEIIGAEMERVAEAREQSQPVRTKTGGSTFKNPPGKKAWELVDAAGCRGLTMGGAQVSEKHTNFLINVDGATSADIEGLGEEVKRRVYAHSGVELEWEIQRVGRP
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM6_PROM5
Sequence: MSKEPPNNSREKTKNLLLKLQDNICKNLENIDGKAKFTEESWLREEGGGGRSRVLKNGSIFEQAGVNFSEVYGKELPQSIISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEAGPVWWFGGGADLTPYYPYLSDVRHFHKEHSNACEKVNKKLHLVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYKGSNKDGNAYKESNNIGELNLNWNNLFALAENCGEAFLSSYQPIIEKRVSQNYTKEEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKQGSREDLLTKIFTRPQDWQNDKVLEEFCLENNIFD
What is the function of this protein?
Involved in the heme and chlorophyll biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GME59_PESMI
Sequence: MAATLGKTIVATGASSGLGFESVKQLLQQSQPYKFIIGARDLKTTQAAFDQVQYDAKTHSVSILPLDLADLRTVKPFAQQTLEALDQDKLDILFLNAGMNKAATGPGLHGSKWCEAYVVNHLSQHYLTQLLRPKLSASHSRVVVVSSGLIRAVKEADIEAFETTLKADSGADGFKVYHASKFVQFLGAHWWRRQLGTSATVLAVSPGLVIGTGLGRHLDTQPNLDHIPDKVTVDKGAKSLLRAFDCNDIPEDPEQIFLTSWGEWWPKDVYSLSLDKSLQDRWCPSQEDIEA
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of dibenzodioxocinones such as pestalotiollide B, a novel class of inhibitors against cholesterol ester transfer protein (CEPT) (PubMed:31474098).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS pks8/GME11356.  Pks8/GME11356 lacks a thioesterase (TE) domain, which is important to the cyclizing of the third ring of atrochrysone carboxylic acid, and the esterase GME11355 might play the role of TE and catalyzes the cyclization reaction of the C ring.  The lactamase-like protein GME11357 (or other beta-lactamases in Pestalotiopsis microspora) probably hydrolyzes the thioester bond between the ACP of pks8/GME11356 and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrates to form endocrocin anthrone.  Endocrocin anthrone is further converted to emodin via the endocrocin intermediate.  Emodin is then oxidized by several enzymes such as the Baeyer-Villiger oxidase GME11358, the oxidoreductase GME11367, the short chain dehydrogenase/reductase GME11373, as well as by other oxidoreductases from the cluster, to modify the A and C rings and open the B ring, and finally yield monodictyphenone.  The prenyltransferase GME11375 may catalyze the addition reaction between the C5 side chains and the carbon bone of dibenzodioxocinones.  The remaining biochemical reactions to the final product dibenzodioxocinones should be methylation catalyzed by methyltransferase GME11366 and reduction and lactonization reaction catalyzed by a series of oxidordeuctases (Probable).
What are the official names of this protein?
Short-chain dehydrogenase/reductase GME11359, Dibenzodioxocinones biosynthesis cluster protein GME11359.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MENG_BACMK
Sequence: MQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRKETMRIMDVKPGSKALDVCCGTADWTIALAGAVGEDGKVYGLDFSENMLAVGKQKVEALELKQVELIHGNAMELPYEDNTFDYVTIGFGLRNVPDYMQVLKEMTRVVKPGGKVICLETSQPTMIGFRQGYVLYFKYIMPLFGKMFAKSYKEYSWLQESASTFPGMKELACMFEEAGLKNVQVKPFTFGVAAMHLGIKPESK
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: MA654_ARATH
Sequence: MIRNSTEQFSRIETTCGLLLRQLQEIWNEMGETEDEKDASLADIEKECLSVYKRKVEEASRGKANLLKEIAVGRAEIAAIGSSMGGQEIHSNSRLGENLKEELENVNVQLDGLRKRKAERMIRFNEVIDQLLKLSLQLGNPTDYLKKFAAEETDLSLQRLEELRSQLGELQNEKSKRLEEVECLLKTLNSLCSVLGEDFKGMIRGIHSSLVDSNTRDVSRSTLDKLDMMIVNLREAKLQRMQKVQDLAVSLLELWNLLDTPAEEQKIFHNVTCSIALTESEITEANILSVASIKRVEDEVIRLSKIKITKIKEVILRKRLELEEISRKMHMATEVLKSENFSVEAIESGVKDPEQLLEQIDSEIAKVKEEASSRKEILEKVEKWMSACEEESWLEEYNRDDNRYNAGRGAHLTLKRAEKARLLVNKLPGMVEALTAKVTAWENERGNEFLYDGVRVLSMLGQYKTVWEEKEHEKQRQRDMKKLHGQLITEQEALYGSKPSPNKSGKKPLRTPVNAAMNRKLSLGGAMLHQSLKHEKATLNSKRTKYYDQNATSRRDSALPTLSGRRNSELPGRIRSKNVPVAGKAARSPMLRKPLSPVTSNILNSPEDHHKDAYTTKERILTPKTNEEKKRAVPTTPAASVAMTEATTPFTPAVEKRMDEEDVIVEYSFEEVRAGFC
What is the function of this protein?
Microtubule-associated protein involved in mitotic spindle formation.
What are the official names of this protein?
65-kDa microtubule-associated protein 4, AtMAP65-4.
What is the protein family that this protein belongs to?
Belongs to the MAP65/ASE1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Localized specifically to MT that rearranged to form a spindle and the polar sides of the spindle proper. Associates to MT in preprophase band, during anaphase, and in phragmoplast.
Protein: PKHG1_HUMAN
Sequence: MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPENPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGSGDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPGSVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPSDVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQIATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNTLHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA
What are the official names of this protein?
Pleckstrin homology domain-containing family G member 1.
Protein: PA21B_MOUSE
Sequence: MKLLLLAALLTAGAAAHSISPRAVWQFRNMIKCTIPGSDPLKDYNNYGCYCGLGGWGTPVDDLDRCCQTHDHCYSQAKKLESCKFLIDNPYTNTYSYSCSGSEITCSAKNNKCEDFICNCDREAAICFSKVPYNKEYKNLDTGKFC
What is the function of this protein?
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (By similarity).  Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity).  May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract.  Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity).  May act in an autocrine and paracrine manner (PubMed:10066760).  Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (By similarity).  Has anti-helminth activity in a process regulated by gut microbiota (PubMed:29024642).  Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (PubMed:29024642).
What are the official names of this protein?
Phospholipase A2, Group IB phospholipase A2, PLA2-Ib, Phosphatidylcholine 2-acylhydrolase 1B.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted from pancreatic acinar cells in its inactive form.
Protein: MURA_HAHCH
Sequence: MDKLLIGGSKPLNGEIRISGAKNSALPILAATLLADEPVTIGNLPHLNDITTMIELLGRMGVELMIDEKMCVEVHANTIKHLTAPYELVKTMRASILVLGPMLAHFGEAEVSLPGGCAIGSRPVDLHIRGLEAMGADILVEGGYIKAKVNGRLKGAHIYMDTVTVTGTENLLMAATLADGKTVIENAAREPEVIDLAECLIAMGADIRGHGSSTIEINGVPRLHGCRYNVLPDRVETGTYLVAAAATRGRVRVKDTREDILEAVLLKLDEAGAHISTGPDWIELDMKGARPKAVSLRTAPYPAFPTDMQAQFVAMNTVAEGTGAIVETVFENRFMHVQELRRMGAKIKLEGNTAIVEGVESLTGAPVMATDLRASASLVIAGLVAEGDTLVDRIYHIDRGYECIEEKMQLLGAKIRRLPG
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P3C2G_RAT
Sequence: MAYNWQTEPNRAEPQEGGHDHQQCHHADQHLSSRQVRLGFDQLVEELSNKTPLPEDEKEGTCFVPDTPNLDSKWQSIYGPHPRHFNEFTSQSPHFSQLPFGKASAIGFNPAVLPAHQFIHEGASWRNPTRKYHGGEDPRFSALTPSSTGLDKCHQQGQSGTEHCNYYVEPENNVPHHYSPYSMDSIPDSEEKGSGDADLVEPSLVFSKDSFLPRASENMSVESTEPIGCPLEIVEAPQGSNKSLASFCNNVTKIRGLYHASDTNSNSGKIWAITTAYPSRLFADTQFRVKISTDNSAQLLLLKPPANYLVKDLIAEILLLCANEQLSPKEYLLSICGSEEFLQTDHCLGSHKIFQKSKSVIQLHLQRSRDTPGKLSRKRDDDRSRVHLNQLLEFTHIWKISRQCLSTVMKSYNLHVEHLLKTQEDVEEKPLSSMFSCGRHPPQPHGNDIIEDVRNICSVLGCIETKQVSDAVKELTLILQRPSQNFHQNSETSKKGFIENVTSELSRSLHQLVDVYCSSFCTDFRPARAPGGVSRDHAGLHSHLSFTVCSLHNVPETWAHSYKAFSFSCWLTYAGKKLCQVKSCRSLPVTKSFSFSVNWNEIINFPLEIKSLPRESMLVIKLFGIDSATHSANLLAWTCLPLFPKEKSPLGSRLLSMTLQSEPPIEMMAPGVWDGSQPTPLTLQIDFPAATWEYVKPETEENRTDHQEPPRECLKHIARLSQKQPPLLLSVEKRRYLWFYRFYCNNENSSLPLVLGSAPGWDEGTVSEMHAVLRRWTFSHPLEALGLLTSRFPDQDIREVAVQQLDNFLTDELLDCLPQLVQAVKFEWSLESPLVELLLHRSLQSIRVAHRLFWLLRDAQGEDYFKSWYQELLAALQFCAGEALIEELSKEQKLVKLLGDIGEKVKSAGDAQRKDVLKKEIGSLEEFFKDIKTCHLPLNPALCVKGIDRDACSYFTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNVWLQEGLDMQMIIYGCLATGKAQGFIEMVPDAVTLAKIHLHSGLIGPLKENTIKKWFSQHNHLKEDYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNTQHFQDFVELCCRAYNIVRKHSQLLLSLLEMMLHAGLPELRGIEDLKYVHDNLRPQDTDLEATSHFTTKIKQSLECFPVKLNNLIHTLAQMPAFSLARPAPQTPPQECCVLNKTRTIQRVTILGFSKTHSNLYLIEVTRSDNRKNLAKKSFEQFYRLHSQIQKQFPLLTLPEFPHWWHLPFTDSHHERIRDLSHYVEQVLHGSYEVANSDCVLSFFLSEHIQQTLEDSPFVDPGDHSPDKSPQVQLLMTYEDTKLTILVKHLKNIHLPDGSAPSAHVEIYLLPHPSEVRRKKTKCVPKCTDPTYNEIVVYDDVSGLQGHVLMLIVKSKTVFVGAVNIQLCSVPLNEEKWYPLGNSII
What is the function of this protein?
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (PubMed:9516481).  May play a role in SDF1A-stimulated chemotaxis (By similarity).
What are the official names of this protein?
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma, PI3K-C2-gamma, PtdIns-3-kinase C2 subunit gamma, Phosphoinositide 3-kinase-C2-gamma.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: TDH_AERHH
Sequence: MKALSKLHKEVGIWMTDVPAPELGHNDLLIKIRKTAICGTDIHIYNWDEWSQKTIPVPMVVGHEYVGEVVAIGQEVRGFAVGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRPGAFAEYLVIPAFNAFKLPDNVPDELAAIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELARKMGATRAVNVTKEQLSGVMSELGMTEGFDVGLEMSGVPSAFQDMIDKMNHGGKIAMLGIPPATMAIDWGKVIFKGLFIKGIYGREMFETWYKMASLIQSGLDLSPIITHRFHIDDFQQGFDAMRSGQSGKVILSWDK
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIC13_HUMAN
Sequence: MVARVWSLMRFLIKGSVAGGAVYLVYDQELLGPSDKSQAALQKAGEVVPPAMYQFSQYVCQQTGLQIPQLPAPPKIYFPIRDSWNAGIMTVMSALSVAPSKAREYSKEGWEYVKARTK
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology.  Required for the incorporation of MICOS10/MIC10 into the MICOS complex.
What are the official names of this protein?
MICOS complex subunit MIC13, Protein P117.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic13 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Note=Enriched at crista junctions.
Protein: RER2_ARATH
Sequence: MAAMAAKLHISTKSDQSNVRLPRLINLSRDPTARVLFPRNGSVSSLHTNFSSPNIMVPCAGGGGGGSIGNHGGGSGSGGGGGGYGGSEEEESSPWGPLGLFIQGWRSRVAADSQFPFKVLMEMLVGVSANVLGDMASRPNFGLNELDFVFSTLVVGSILNFTLMYLLAPSAISHGSSNLLPGIFRSCPSSHMFEQGNFTLMNRFGTLVYKGMVFATVGLAAGLVGTAISNGLIMLRKKIDPSFETPNKPPPTLLNSLTWATHMGVSANVRYQTLNGAEFLLEKSLPPLVFKTSVIALRVVNNVLGGMSFVTLARMTGSQSVEEEKKIEMSEISEKEKED
What is the function of this protein?
May play a role in leaf development.
What are the official names of this protein?
Protein RETICULATA-RELATED 2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the RETICULATA family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: BRK1_PHYSG
Sequence: APPGFTPF
What is the function of this protein?
Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity).  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
Des-Arg9-[Ala1,Thr6]-bradykinin, Des-Arg-[Ala1,Thr6]-bradykinin.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: KGUA_BACCR
Sequence: MRSRRGLLIVLSRPSGVGKGTVRKELFSHEDTRFQYSISVTTRKPREGEVDGVDYFFKEREEFEEMIRNEKLLEWAEFVGNYYGTPIDYVEKTLQEGKDVFLEIEVQGAIQVKKAFPEGVFIFLAPPSLSELKSRIVGRGTETEDVIENRLTVAKEEIEMMDAYDYVVENDQVELACDRIKAIVVGEHCRRERVAKYYKEMTEGL
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIN28_ENCCU
Sequence: MKTYIRERRLGEGTYAVIYLGYRALPQDKPLVSSGTRIEDVPVAIKKIKPTKYTQGHEISAIREIKSLKRIDSKYVVRLIDTFVYDKCVHIVLEYVETNLENVIRNSDKIIMPGDIKAWILMVLRGVYECHRLFIIHRDIKPNNILITSEGMVKLADFGLTRGIGNRMTPQAVTRWYRAPELLMGSRDYGSPVDMWSVGCVFAELFLRVPLFAGDTDIQQLDMIFRALGTPVEREWPGVSTLPEFLDFQQYPKASLNGLFSAASSDALDLLEKLLTLNPCNRISCDDAIKHPYFKSSPPPTPIGKLPV
What is the function of this protein?
Protein kinase component of transcription factor IIH (TFIIH) which phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription.  Essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA (By similarity).
What are the official names of this protein?
Probable serine/threonine-protein kinase KIN28 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ORF2_TTVF1
Sequence: MSASHSLSQSPNLHPDFTYKRQEALWKQLVSAEHRKFCSCGDYTQHFRFPSPVKEDECIRVVGEEGGDGVAVSYHVTKESGDEDPEEVMASIAVGDDGDDDLELW
What are the official names of this protein?
Uncharacterized ORF2 protein.
Protein: PTH_MYCSK
Sequence: MAEPLLVVGLGNPGPNYAKTRHNVGFVVADLLAGRIGSGFKAHRKSGADIATGRLAGRAVVLAKPRTYMNESGRNVGPLAKFYSVAPADVIVIHDELDIDFGRIRLKFGGGVAGHNGLKSVAAALGTKDFQRVRVGVGRPPGRKDAATYVLEPFTSVERPEVPTICEQAADATELLIAQGLEPAQNLVHAWA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_MYXXD
Sequence: MRSKKTKFIFVTGGVVSSLGKGLASASIGALLENRGLAVTLIKLDPYINVDPGTMSPFQHGEVFVTEDGGETDMDLGHYERFTNARMSRLNNFTSGRIYHAVIMKERRGEYLGKTVQVIPHVTDEIKSSIRQAAQDADVVIVEVGGTVGDIESLPFLEAIRQMRYDVGNENVVYVHLTLLPYIGAAGEVKTKPTQHSVMKLREIGIQPDFLVCRTDREVPRELKDKIAMFCNVDTRSVFTSPDVRSTYELPLELHRQGLDERLAEVLNIWSRAPHLERWENIIRKVYEPARGQVRIAIVGKYVNLTESYKSLNEALLHGGIANDVKVNLHFVDSQEVEEQGAEKLLAGVDAILVPGGFGVRGTEGKIAAVRYAREKKVPFFGICLGLQMAVVEFSRGVLGLSSANSLEFNEHTPHPVVTLMESQVKVQDKGGTMRLGSYACALKPGSLAHQLYGQDTIQERHRHRYEVNNAYRSKLQEAGLVISGSNPELNLVEMIELADHPYFIGCQFHPEFKSKPFAPHPLFSGFIRAALAQRDANAAAGKVTE
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: Y4629_DESHY
Sequence: MFYAIILFILAGLAEIGGGYLVWLWLREAKPFWYGIIGGLILVLYGVIPTLQKFPSFGRVYAAYGGVFVILAVLWGWGIDKKVPDNYDWIGAVICLVGVSVMLWAPRN
What are the official names of this protein?
UPF0060 membrane protein DSY4629.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.