PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_YERE8
Sequence: MESIIQQINQLRTSLRHHEHLYHVLDAPEIPDAEYDRLMQQLRELEAQHPELITNDSPTQRVGAAPLDAFEQVKHEVPMLSLDNVFDEESYLAFDKRVHDRLKRADPLTFCCELKLDGLAVSLLYEDGELVRAATRGDGTTGENITANVRTIRAIPLRLQGDNIPRRVEVRGEVFMPLAGFEQLNDEARRKGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGLLEGGELPRSHIQRLMQFKAWGLPVSERVKLCTGSEQVIAFYRQVEQDRGGLGFDIDGVVIKVDSLDLQEQLGFVARAPRWATAFKFPAQEQITQVREVEFQVGRTGAITPVARLEPVQVAGVIVSNATLHNADEIERLGLRIGDTVIVRRAGDVIPQVVGVVMDQRPQDAKEITFPEHCPVCGSDIERVEGEAVARCTGGLFCAAQRKEALKHFVSRRALDVDGMGDKIIEQLVEKQYVENPADLFTLTAGKLTGLDRMGPKSAQNLIVALEKAKQTTFARFLYALGIREVGEATAANLAAHFRNLENLRAADIEALKSVPDVGEVVAKHVVNFLGEEHNQKVIEALEKVITWPEPQQIIAEEIDSPFAGKTVVLTGSLTILSRDEAKDRLAALGAKVSGSVSKKTDLVIAGEAAGSKLVKAQELGITVIDEAEMIRLLGESS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: NSE3_SCHPO
Sequence: MSQLSFTGKSSSKGRSRLTQEVRPTASQIIADEEASDLDEYEEDLEGSGNEDDFGPSMSRSSRGRKRRKGDPLELQSQFEERNETDAINFQLLVRNVVRYAICSQTSHNTITRKDIVQKAFPEGTSRNLFQSVFEEADRQLQLSFGFRLVAVTQSNRKKDMAVSQLRRPATSNANSSNLHRYWVLRSTLPMELQKDSRLIVDSVLDTAYYGFLMTVIAFIAVSHCSVGHSELQSFLQELLTEEETTPLHLDITRSLSLLVRQGYLDRVKDDTHNQFVYYIGSRAVTEISIEGLKSFVTEFFPDSDIDMDALLTEYRQEYQNQSSSSAA
What is the function of this protein?
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage.  Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.  Plays a critical role in meiosis.
What are the official names of this protein?
Non-structural maintenance of chromosome element 3, Non-SMC element 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTNA_ANADE
Sequence: MTVREPLRPVLYDDARDLVRLLDQKALPAEERWLELSTAEAVAAAIQDLTVRGAPAIGVAAAYALAVEARRGAGPERLRAAADLLARARPTAVNLAWAVRRMSARIGAPASDVLAEAHAIRDEDEAACRRIGALGAPLVPARARVLTHCNAGALATAGYGTALGVVRAAVEAGNAISVFADETRPFLQGARLTAWELHRDGIPVTVLTDGMAGWLMARGEIGCVVVGADRIAANGDVANKIGTYALAVLAAHHRLPFYVAAPWSTVDLATPTGADIPIEERASDEVVVLAGQRIAPAGVPARYPAFDVTPAALVTAIVTERGVVRAPHAAGLAALATAR
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: S39A3_XENTR
Sequence: MNLIFAKVLCLLAILVLMMLGSLIPVKISEADFDKSSRSRKILSLSNSFAGGVFLATCFNALLPAVREKFFDLLKIGNISTDYPLAETIMMVGFFLTVFVEQTVMTFRKEKPSFIDMETFNAGSDIGSDSEFESPFISANHGHNLYEGGHSHHSHSLNIKELSSSSPIRLFSLVFALSAHSVFEGLALGLQEDGNKLLSLFIGVVIHETLVAMALGVSMAKVNTHLKDAIKMAVLVSTMIPIGIVVGMAIQSAQNMASSIASALLQGIAGGTFIFVTFFEILVKELEEKNDRLLKVLFLVLGYTVLAVLVLFKW
What is the function of this protein?
Transporter for the divalent cation Zn(2+).  Mediates the influx of Zn(2+) into cells from extracellular space.
What are the official names of this protein?
Zinc transporter ZIP3, Solute carrier family 39 member 3, Zrt- and Irt-like protein 3, ZIP-3.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CLD17_PIG
Sequence: MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFIGSNIIVFERIWEGLWMNCVRQAKARLQCKFYSSMLALSPALEAARALMCVAVALSLIALIIGICGMKKIQCTGSNERAKAYLLGTSGVLFILTGIFVLIPVCWTANIIIRDFYNPAVHVGQKRELGAALFLGWASVAVLFIAGGLLCGFCCCNRKKQRDGYPAPRPSMPRTDERRRNMTRQSETPTSYV
What is the function of this protein?
Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter.  In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions.  Does not affect water permeability.
What are the official names of this protein?
Claudin-17.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: TRPC_MICAN
Sequence: MQIRRKHPNPAVKVESLSYVVKVPEAQPQNILEEIVWHKEIEVDKLRERLPLLELRQKIANTAPPCDFLAALKQGKTQPALIAEVKKASPSKGVILEDFDPVAIARTYEQGGATCLSVLTDSKFFQGSYENLTLVRQAVSLPLLCKEFILYPYQIYYARSKGADAVLLIAAILSDQDLAYFVKIVKGLGMTALVEVHSLAEFDRVLAIEGIELIGINNRNLETFTVDLDNTRQLLEARGEQVREKGILIVSESGLHTATDLAKVKQAGANAVLIGESLVKLPDPALGIQKLFENLG
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: ARLY_YERPG
Sequence: MALWGGRFSQAADQRFKQFNDSLRFDYRLAEQDIIGSVAWSKALVTVGVLNADEQQQLEQALSVLLEEVQANPHAILASDAEDIHSWVETKLIDKVGDLGKKLHTGRSRNDQVATDLKLWCKFQITELQTAVQQLQQALVMTAEANQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLSRDESRLQDTLKRLDVSPLGCGALAGTAYAIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSDASIGMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMTMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCKEAAEQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKALEALALSDLQQFSSVIGDDVYPILALQSCLDKRVAKGGVSPQQVASAIAEAKARLF
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUD9_YEAST
Sequence: MTKITRDVSITTENSKSTSGSATASSASLPENDHPIFHQPRARIRSGSLFIEGSDSFPSSEVKSYNVYIDDSKYSEILKGDTNSSSTDGKQVFEDARDDNFHQESHRDLEDSILDLVRRDPEVAAFPLPPPNSNERNRNSSNGSSAETNLNGHSSSGTISTSVLLNMGSAEKHAGTTRGDHMESSSMKSFEKLGTRPSSLFYPPPEGTAPYQGPRATVSGNKSTRQTQGTYSFPSMRYGVDLVSPVEGAVDVAKSRVPNSTLNGTFPDKAFIPHEFQIPKKAWNRIPANKSTSLKTPRNHSLLIDILKPFEAADLANDQRSSSAVLKNTVHSNGQYNPTNETSGTRMQDQRQKNTNEIDLEKIPNPQVPLGIAMDTMRSPNQLHEKEYESNIEAGLASGVGKGDNSIKQHQYKKIPQEIDRDQQLSFQMETMPIQRIDSSSIRSFDSRIYGFSEIYSIPRVITTLCICLFVPPLFFFFSINGNNGVSNYRLMRMIMNYEHRIGLLKGFEWDIDVQWFRTLCFVLGCIEMLAIFASIGIGFGVGIIRE
What is the function of this protein?
May be involved in positioning the proximal bud pole signal.
What are the official names of this protein?
Bud site selection protein 9.
What is the protein family that this protein belongs to?
To yeast BUD8.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Found at the necks of large-budded cells and the proximal poles of daughter cells.
Protein: HUPJ_RHOCA
Sequence: MSGPTRAGFEGSYLGANDRISDLAIMECKICWTPYDPASGDEFRQVLPGTPFTALPEDWHCPNCDAPKAQFIVQSDPGAPALLEQNRVDAQVSALVADFREIWHSKMRDVPLVNKALSIEAVGFRSHEGRGLGVLVSPWFMNLIQLPAAGEDWSGLIPGVKEDLEFPSGLYEFIHNRREMVGGYKACSLYPTMGDFQTQMQAVDLARAVMIELFKAENRAETDRAAEIRASRTAELAALEAAEAEKAETAARAEAMAQPTRRRLISAGLAGEDEGAAE
What are the official names of this protein?
Probable rubredoxin HupJ.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the HupJ family.
Protein: IF11_ACISJ
Sequence: MSNKEQLIEMQGKVDEVLPDSRFRVVLENGHTLIAYSGGKMRKHRIRVLAGDTVSLEMSPYDLTKGRITFRHLEPRAGGAPRRPSPHRR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_BURP0
Sequence: MSAPLSLFVTGTDTEIGKTFVSAALLHGFARAGLRAAAMKPVAAGAYERDGAWRNEDADQLDAAANVALPAAIRTPFLLKAPAAPHIVAAREGVALDIGTIVDAHRRACEMADVIVVEGVGGFRVPLADTRDTADLAVALGLPVVLVVGVRLGCISHALLTAEAIAARGLPLAGWVANRIDPAMPFADDNVDTLRAWLEREHRAPLLGALAHMSPPSPDAASHALDVNLLLNALRAAAPR
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_STAS1
Sequence: MMIVIMLILSYLIGAFPSGYVIGKLFFKKDIRQFGSGNTGATNSFRVLGKPAGFLVTFLDIFKGFIVVFFPLWLPVQAEGPITTFFTNGLIVGAFAILGHVYPVYLGFKGGKAVATSAGVILGVNPVLLLILAAIFFGILYLTKYVSLSSIIASICCVIGALLIRDYILFIVSIGVGVLLIIRHRTNIVRIFKGEEPKIKWM
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SPVC_SALCH
Sequence: MPINRPNLNLHIPPLNIVAAYDGAEIPSTNKHLKNNFNSLHNQMRKMPLSHFKEALDVPDYSGMRQSGFFAMSQGFQLNNHGYDVFIHARRESPQSLGKFAGDKFHISVLRDMVPQAFQALSGLLFSEDSPVDKWKVTDMEKVVQQARVSLGAQFTLYIKPDQENSQYSASFLHKTRQFIECLESRLSENGVISGQCPESDVHPENWKYLSYRNELRSGRDGGEMQRQALREEPFYRLMTE
What is the function of this protein?
Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif present in MAPKs, via a beta-elimination reaction leading to a dehydrobutyrine residue.
What are the official names of this protein?
MAPK phosphothreonine lyase, 27.5 kDa virulence protein, Secreted effector protein SpvC.
What is the protein family that this protein belongs to?
Belongs to the phosphothreonine lyase family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPR1A_RAT
Sequence: MSSQQQKQPCTVPPQLHQHEVKQPCQPPPQEPCAPKTKEPCHPIPEPCNPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCHPKAPEPCHPVVPEPCQPVAPEPCQPVVPEPCPPTVTPSPYQQKTKQK
What is the function of this protein?
Cross-linked envelope protein of keratinocytes.  It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase.  All that results in the formation of an insoluble envelope beneath the plasma membrane.
What are the official names of this protein?
Cornifin-A, Small proline-rich protein 1A, SPR1A, SPRR1.
What is the protein family that this protein belongs to?
Belongs to the cornifin (SPRR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_KLEP3
Sequence: MSSYDNHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLHADNLPFHGADIWTLYELSWLNGKGLPQVAVGHVELPDTSVNLVESKSFKLYLNSFNQTRFASWQDVAETLTRDLSACAQGEVKVALYRLDELEGQPIAHLHGACIDDQDIEIDNYQFSTDYLQGAASGKIVEETLVSHLLKSNCLITHQPDWGSVQIQYRGAKIDREQLLRYLVSFRHHNEFHEQCVERIFNDILRFCQPESLSVYARYTRRGGLDINPWRSNGDFSPATGRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TLR22_CHICK
Sequence: MHTWKMWAICTALAAHLPEEQALRQACLSCDATQSCNCSFMGLDFIPPGLTGKITVLNLAHNRIKVIRTHDLQKAVNLRTLLLQSNQISSIDEDSFGSQGKLELLDLSNNSLAHLSPVWFGPLFSLQHLRIQGNSYSDLGESSPFSSLRNLSSLHLGNPQFSIIRQGNFEGIVFLNTLRIDGDNLSQYEPGSLKSIRKINHMIISIRRIDVFSAVIRDLLHSAIWLDVRKLAFSVPEKIQLLRIMSSSFAKKISLKQCLFTDATVPEIVSILEGMPKLMEVEMKDCTLLGTGKWYKQIHANQSQSLRILTIENLSIEEFYLFTDLQSVLDLLSLFRKVTVENTKVFLVPCKLSQHLLSLEYLDLSANLLGDQSLEHSACQGAWPSLQTLNLSQNSLSDLKMTGKSLFHLRNLNLLDISENNFGEIPDMCEWPENLKYLNLSSTQIPKLTTCIPSTLEVLDVSANNLQDFGLQLPFLKELYLTKNHLKTLPEATDIPNLVAMSISRNKLNSFSKEEFESFKQMELLDASANNFICSCEFLSFIHHEAGIAQVLVGWPESYICDSPLTVRGAQVGSVQLSLMECHRSLLVSLICTLVFLFILILVVVGYKYHAVWYMRMTWAWLQAKRKPKRAPTKDICYDAFVSYSENDSNWVENIMVQQLEQACPPFRLCLHKRDFVPGKWIVDNIIDSIEKSHKTLFVLSEHFVQSEWCKYELDFSHFRLFDENNDVAILILLEPIQSQAIPKRFCKLRKIMNTKTYLEWPPDEEQQQMFWENLKAALKS
What is the function of this protein?
Participates in the innate immune response to microbial agents.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).
What are the official names of this protein?
Toll-like receptor 2 type-2.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TOP6A_PYRFU
Sequence: MKLKRGKPKEKFSYDPQKVLKKLEDLAYKILEEVKAGKNPYFDVPTRGLSNVYFDEEARLIKLGDKLSRRYFLNVAHARKFMQTLILMAYVKRLVSEGKHASLREAYYANKHTIPGTHENTFEDQSESDPIIEDLERMLGVLREEMHITADRRGYVYGDIVIKDGEDEFNASKLGMGGWAVPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRERALIIATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYGLEHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit A, Type II DNA topoisomerase VI subunit A.
What is the protein family that this protein belongs to?
Belongs to the TOP6A family.
Protein: PRIL_METTH
Sequence: MVSSLFINPFSEDAREIVRKYGSLDTIDDTRDELLEIGRRTRGQNLADNSLLPASIAELAVKRLEWYLRRQRKDFNHRDYAYLMNPEIEEYDVLAFYILAQAAGAGFMKASREARLVVESAGAMVEDRLNVFGGEREEIMAEVLYELGSEGLRWTELADLLGSGKLKLTDLILKEGRVIIDRDEFITSFQDSIRDRSPDRLYDILVGLEVRETMISRMIMQRTEEYIGMVREMSSTVEVHPLILETAERIRETVEEIMSFTGGPVKSARPGKLVQEAFPPCIRGTLDGVRSGNRNDAIVLLLTSFISYARLYPSVFRDRTPMKVSDLDPDLRITLGEILPVIYDAADRCEPPLFEDDPQEKLNITAKLGFGVHDMPELENEGESKWYTPMSCEKIKIHLPDLCRPDKLCSSISNPLTYYNRKRWKLRSSGEKEE
What is the function of this protein?
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase large subunit PriL.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase large subunit family.
Protein: YFB2_YEAST
Sequence: MPKSRPKRTIASSSSVFYGSSPFQNDGYIKVMELVSHIVIEINHSPTATTDETRKQNNPELKVKEPVCNLKKWENNTNFILEDHTKNKTKLSSTDRIRKWFRRHILKEEIEILSHGKQLSSIDEDYCPSNVLVGCSRDLNKLRSFQNF
What are the official names of this protein?
Uncharacterized protein YFL012W.
Protein: PSBN_RHDSA
Sequence: METATVLIVFIASLLLGVTGYSVYTAFGPNSKDLRDPFEDHED
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ATPE_CLOB6
Sequence: MKDNIELTIFTPEKNIKIGEIKEVITEGLDGDLAILPNHVNMITYLKPTITKYIDLNGNKNNIFTSSGVLKVEDNKVYIICDASEKPEDIDIKRAENAKKRAEERLRNKKEIDVKRAELALFRSIARIKIKEL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UBC10_DROME
Sequence: MTAPRRLRKELSDLQGNALKSFRDIKADDDNLLRWTGLIVPDNPPYNKGAFRIEINFPAEYPFKPPKINFKTRIYHPNIDEKGQVCLPIISTENWKPATRTDQVVQALVDLINDPEPEHPLRAELAEEFLKDRKKFVKNAEDYTKKHSEKRPAD
What is the function of this protein?
Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin (PubMed:27702987, PubMed:29689197, PubMed:21900267).  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity).  Appears to be involved in the selective degradation of short-lived and abnormal proteins (PubMed:29689197, PubMed:27702987, PubMed:21900267).  Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex (PubMed:29689197).  Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation (PubMed:29689197).  Likely to function with ari-1 to control metamorphosis by regulating the proteins levels of EcR isoform A (ECR-A) and it's heterodimeric partner usp, via the ubiquitination and subsequent degradation of ECR-A (PubMed:21900267).  Able to function with LUBEL to mediate 'Lys-63'- and linear 'Met-1'-linked polyubiquitin involved in the heat stress response (PubMed:27702987).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2-18 kDa, Ubiquitin conjugating enzyme 10.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: GUAA_NITMU
Sequence: MVMHQKILILDFGSQYTQLIARRVRESNAYCEIHPFDISSQFIGNFAPAGIILSGGPASVAENETPRAPQIVFELGVPVMGICYGMQTMAAQLGGSVENSKVREFGYAELQVKNLAGLLQDIHDRTDASRQKLLDVWMSHGDSVNTLPPGFQVMASNPATPLAAIADGARRFYGMQFHPEVTHTPQGKAIIDRFVHEICGLAYDWNMPDYLEEMVGRIRSEVGPDEVILGLSGGVDSSVAAALIHRAIGKQLTCVFVDNGLLRLNEAEQVMDTFSRNLGVKVIHVDASEEFLGHLQGITDPEAKRRIIGREFVEVFQREAAKIANARWLAQGTIYPDVIESAGAKTKKANTIKSHHNVGGLPETLHLKLLEPLRELFKDEVRELGLTLGLPHDMVFRHPFPGPGLGVRILGEVKREYAELLRRADAIFIEELRNAGWYEKTSQAFAVFLPVKSVGVMGDGRTYDFVVALRAVQTEDFMTARWAELPYALLARISSRIVNEVRGINRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: DRC3_HUMAN
Sequence: MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKTELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISELFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEISISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTRINSWCTRLIDRIHKDEIMRNRKRVKEINQYIDHMQSELDNLECGDILD
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
What are the official names of this protein?
Dynein regulatory complex subunit 3, Leucine-rich repeat-containing protein 48.
What is the protein family that this protein belongs to?
Belongs to the DRC3 family.
Protein: MVP_CMVFN
Sequence: MAFQGTSRTLTQQSSAATSDDLQKILFSPEAIKKMATECDLGRHHWMRADNAISVRPLVPEVTHGRIASFFKSGYDVGELCSKGYMSVPQVLCAVTRTVSTDAEGSLRIYLADLGDKELSPIDGQCVSLHNHDLPALVSFQPTYDCPMETVGNRKRCFAVVIERHGYIGYTGTTASVCSNWQARFSSKNNNYTHIAAGKTLVLPFNRLAEQTKPSAVARLLKSQLNNIESSQYLLTNAKINQNARSESEDLNVESPPAAIGSSSASRSEAFRPQVVNGL
What is the function of this protein?
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding.  The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier.  Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (By similarity).
What are the official names of this protein?
Movement protein, MP, Protein 3A.
What is the protein family that this protein belongs to?
Belongs to the cucumovirus movement protein family.
What are the subcellular locations of this protein?
Host cell junction, host plasmodesma. Note=Assembles into long tubular structures at the surface of the infected protoplast.
Protein: Y1419_HELPJ
Sequence: MFEKIRKILADIEDSQNEIEMLLKLANLSLGDFIEIKRGSMDMPKGVNEAFFTQLSEEVERLKELINALNKIKKGLLVF
What are the official names of this protein?
Uncharacterized protein jhp_1419.
Protein: CAPSH_ADE12
Sequence: MATPSMMPQWSYMHIAGQDASEYLSPGLVQFARATDTYFTLGNKFRNPTVAPTHDVTTDRSQRLTLRFVPVDREDTTYSYKARFTLAVGDNRVLDMASSYFDIRGVLDRGPSFKPYSGTAYNSLAPKGAPNASQWSDNAKLNTFAQAPYLSDTITAADGIKVGTDTAQAGAAVYANKTYQPEPQVGPSEWNTSIENVKAGGRALKQTTAMQPCYGSYARPTNEHGGQSKDDNIELKFFDSANNAANTAQVVFYTEDVNLEMPDTHLVFKPTVTNGTIASESLLGQQAAPNRANYIAFRDNFIGLMYYNSTGNMGVLAGQASQLNAVVDLQDRNTELSYQLMLDALGDRTRYFSLWNSAVDSYDPDVRVIENHGVEDELPNYCFPLSAVGEIKNYKGIKPDNGGGGGWTADNTVSEANHIGIGNIAAMEINLQANLWRSFLYSNVGLYLPDDLKYTPGNIKLPDNKNTYEYMNGRVTAPGLVDTYVNIGARWSPDVMDNVNPFNHHRNAGLRYRSMLLGNGRFVPFHIQVPQKFFAIRNLLLLPGSYTYEWNFRKDVNMILQSTLGNDLRVDGASVRFDNIALYANFFPMAHNTASTLEAMLRNDTNDQSFNDYLCAANMLYPIPANATSVPISIPSRNWAAFRGWSFTRLKTKETPSLGSGFDPYFVYSGTIPYLDGTFYLNHTFKKVSIMFDSSVSWPGNDRLLTPNEFEIKRSVDGEGYNVAQCNMTKDWFLIQMLSHYNIGYQGFYIPESYKDRMYSFFRNFQPMSRQVVDTTEYKNYKKVTVEFQHNNSGFVGYLGPTMREGQAYPANYPYPLIGQTAVESITQKKFLCDRVMWRIPFSSNFMSMGALTDLGQNMLYANSAHALDMTFEVDPMDEPTLLYVLFEVFDVVRIHQPHRGVIEAVYLRTPFSAGNATT
What is the function of this protein?
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid.  Assembled into trimeric units with the help of the chaperone shutoff protein.  Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid.  Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
What are the official names of this protein?
Hexon protein, CP-H, Protein II.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae hexon protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.
Protein: SIGS_STAA9
Sequence: MKFNDVYNKHHKIIHHLLKKYNISYNYDEYYQLLLIKMWQLSQIYKPSSKQSLSSFLFTRLNYYLIDLFRQQNQLKDVILCENNSPTLTEQPTYFNEHDLRLQDIFKLLNHRERLWLKLYLEGYKQFEIAEIMSLSLSTIKLIKMSVKRKCQHNFN
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival (By similarity).
What are the official names of this protein?
RNA polymerase sigma factor SigS.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.