PharMolix/UniProtQA huggingface dataset:
Protein: VDH_CORGL
Sequence: MTATFAGIDATKHLIGGQWVEGNSDRISTNINPYDDSVIAESKQASIADVDAAYEAAKKAQAEWAATPAAERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKANLEITLAGNITKESASFPGRVHGRISPSNTPGKENRVYRVAKGVVGVISPWNFPLNLSIRSVAPALAVGNAVVIKPASDTPVTGGVIPARIFEEAGVPAGVISTVAGAGSEIGDHFVTHAVPKLISFTGSTPVGRRVGELAINGGPMKTVALELGGNAPFVVLADADIDAAAQAAAVGAFLHQGQICMSINRVIVDAAVHDEFLEKFVEAVKNIPTGDPSAEGTLVGPVINDSQLSGLKEKIELAKKEGATVQVEGPIEGRLVHPHVFSDVTSDMEIAREEIFGPLISVLKADDEAHAAELANASDFGLSAAVWSKDIDRAAQFALQIDSGMVHINDLTVNDEPHVMFGGSKNSGLGRFNGDWAIEEFTTDRWIGIKRS
What is the function of this protein?
Catalyzes oxidation of vanillin to vanillate.  Oxidates also 3,4-dihydroxybenzaldehyde and 4-hydroxybenzaldehyde significantly.  Other aromatic aldehyde substrates in the order of decreasing activity include 3-hydroxybenzaldehyde, 4-nitrobenzaldehyde, terephthalaldehyde, 2,4-dichlorobenzaldehyde, benzaldehyde and 3-phenylpropanal.  Low activity with phthalaldehyde, cinnamaldehyde and syringaldehyde.  No activity with phenylacetaldehyde, formaldehyde or aldehyde.  Active with both NAD(+) and NADP(+) (PubMed:25622822).  Involved in the degradation pathway of lignin-derived aromatic compounds of plant cell walls.  Catalyzes the conversion of vanillin to vanillate due to toxicity of vanillin to the cells (Probable).
What are the official names of this protein?
Vanillin dehydrogenase, Aromatic aldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: RUVA_ENDTX
Sequence: MIDYLYGTLDSKSTDGITIDVNGIGYEISVPISTFLKLPETRNPIKIYIVESTAGMYGGVISLYGFFTIEEREMYLLIKDKVHGIGAKKAMEYTDKISKSFANFKTAIISKNPSMLNEIFGFTKKTADKLIVALKDKISTVNVLNKEKQTGAETIKNTMVSEAIAGLITLGYKMQQARVAVTNVYEHNENITLEDLIKKSLQYL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: EFTU_EHRCR
Sequence: MVEERKPHINVGTIGHVDHGKTTLTAALTTVLAKRLSGEGNKSVKYDEIDKAPEEKARGITISTAHVEYETENRHYAHVDCPGHADYIKNMITGAAQMDAAILVVSATDGAMPQTREHILLAKQVGVKDIVVWMNKCDVVDDEEMLSLVEMEIRELLSKYGYPGDDIDVVRGSAVKALEEETGSGVWSEKIMELMNALEKISLPTREKDKPFLMSIEDVFSIPGRGTVVTGRIERGVIRVGDKIEIVGLRDIQSTVCTGVEMFHKALDAGEAGDNAGILLRGIKKEDVERGQVLSAPGQIHSYKKFKAEVYILKKEEGGRHTPFFSNYQPQFYVRTTDVTGSIKLPEGVEMVMPGDNISIEVSLDKPVAIDKGLRFAIREGGRTVGSGIITEILE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EAT1_CYBJN
Sequence: MFPTRVLRSTLQKLPHRETVPMAYDLHMPQRSLFQNLNEKHTEPIVFLHGIFGSKKSYELDSKMIAHGTHTPVYTVDIRNHGQTSHAMPFNYDTLAQDVKEFCHVQGLKSVKLVGYSLGAKISMLAALKYPELVKSAVIIDNAPVKQPYIELYMKQYVKSMLHVLEEAKIKTTDKDWKNKASDAMKKFLPNGVIRKNLLVNLVNKKPDGFESPVVNFDEGLIQFLNPIRQMEEAAVKDVTDWPEESTEGLKYNGPVKFIKGLKSPFINEEGMTKIQDIFPNNEFANVNSSHDILDQRPTEYVKIICDFFNAHRYESAPSNTIIGHKDFKTTIDMRV
What is the function of this protein?
Alcohol acetyltransferase that catalyzes the synthesis of ethyl acetate from ethanol and acetyl-CoA (PubMed:28356220).  Can also function as a thioesterase by hydrolyzing acetyl-CoA in the absence of ethanol, as well as esterase hydrolyzing ethyl acetate (By similarity).
What are the official names of this protein?
Ethanol acetyltransferase 1, Acetyl-CoA hydrolase, Acetyl-CoA thioesterase, Alcohol acetyltransferase, AAT, Ethyl acetate esterase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RFA1_DROME
Sequence: MVLASLSTGVIARIMHGEVVDAPVLQILAIKKINSAADSERYRILISDGKYFNSYAMLASQLNVMQHNGELEEFTIVQLDKYVTSLVGKDGAGKRVLIISELTVVNPGAEVKSKIGEPVTYENAAKQDLAPKPAVTSNSKPIAKKEPSHNNNNNIVMNSSINSGMTHPISSLSPYQNKWVIKARVTSKSGIRTWSNARGEGKLFSMDLMDESGEIRATAFKEQCDKFYDLIQVDSVYYISKCQLKPANKQYSSLNNAYEMTFSGETVVQLCEDTDDDPIPEIKYNLVPISDVSGMENKAAVDTIGICKEVGELQSFVARTTNKEFKKRDITLVDMSNSAISLTLWGDDAVNFDGHVQPVILVKGTRINEFNGGKSLSLGGGSIMKINPDIPEAHKLRGWFDNGGGDSVANMVSARTGGGSFSTEWMTLKDARARNLGSGDKPDYFQCKAVVHIVKQENAFYRACPQSDCNKKVVDEGNDQFRCEKCNALFPNFKYRLLINMSIGDWTSNRWVSSFNEVGEQLLGHTSQEVGEALENDPAKAEQIFSALNFTSHIFKLRCKNEVYGDMTRNKLTVQSVAPINHKEYNKHLLKELQELTGIGSSN
What is the function of this protein?
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress.  It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism.  Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
What are the official names of this protein?
Replication protein A 70 kDa DNA-binding subunit, RP-A p70, Replication factor A protein 1, RF-A protein 1, Single-stranded DNA-binding protein, DmRPA1.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSI1_ORYSJ
Sequence: MPKATAAEEEEFRAEVEERLINEEYKIWKKNTPFLYDLVITHALEWPSLTVQWLPDRAEPAGKDHSVQKMVLGTHTSDNEPNYLMLAQVQLPLDDAEADARHYDDDHAEIGGFGAASGKVQIVQQINHDGEVNRARYMPQNSFIIATKTVSAEVYVFDYSKHPSKPPLDGACNPDLRLKGHNSEGYGLSWSIFKEGHLLSGSDDAQICLWDIKANSKNKTLDALQIFKYHDGVVEDVAWHLRHEYLFGSVGDDHNLLIWDLRSPVSTKPVQSVAAHQGEVNCLAFNPFNEWVVATGSTDKTVKLFDLRKIDTSLHTFDCHKEEVFQVGWSPKNETILASCCLGRRLMVWDLSRIDQEQTPEDAEDGPPELLFIHGGHTSKISDFSWNPCEDWVIASVAEDNILQIWQMAENIYHDEDDVPTDDPAKAP
What is the function of this protein?
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.  Component of several complexes which regulate chromatin metabolism such as the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (By similarity).
What are the official names of this protein?
Histone-binding protein MSI1 homolog, CAF-1 p48 homolog, Chromatin assembly factor 1 subunit MSI1 homolog, CAF-1 subunit MSI1 homolog, WD-40 repeat-containing protein MSI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1703_MYCTU
Sequence: MAAGIRNITTTGQIGDGREAAAVDYVLAHAGAGNIDDVLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEARVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLEYQTLVPDLVLESEYLG
What is the function of this protein?
Specifically methylates an O atom of its substrate.
What are the official names of this protein?
Probable O-methyltransferase Rv1703c.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
Protein: UBIA_TOLAT
Sequence: MMSVIPAQWQPYWQLARLDKPIGTLLLLWPTLWALWLASAGVPSFSLLLIFTAGVFVMRSAGCVINDYADRKFDGYVKRTASRPLPAGRLTAVRALLFFLLLVLIAFVLVWQLNQFTIYLSVGGLLLAAIYPFMKRVTSLPQVVLGMAFSWAIPMAYGAVVGQLTVTTWLLFLANLVWTIAYDTMYAMVDRDDDLKIGVKSTAILFGQNDRLYIALLQLGTLTLLAIIGWLEQLTVSYYFSLLLAAGLFIYQQWLIRHRQRDACFRAFLNNNWVGMLIFAGIMLAC
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NEEDL_BPT4
Sequence: MEMISNNLNWFVGVVEDRMDPLKLGRVRVRVVGLHPPQRAQGDVMGIPTEKLPWMSVIQPITSAAMSGIGGSVTGPVEGTRVYGHFLDKWKTNGIVLGTYGGIVREKPNRLEGFSDPTGQYPRRLGNDTNVLNQGGEVGYDSSSNVIQDSNLDTAINPDDRPLSEIPTDDNPNMSMAEMLRRDEGLRLKVYWDTEGYPTIGIGHLIMKQPVRDMAQINKVLSKQVGREITGNPGSITMEEATTLFERDLADMQRDIKSHSKVGPVWQAVNRSRQMALENMAFQMGVGGVAKFNTMLTAMLAGDWEKAYKAGRDSLWYQQTKGRASRVTMIILTGNLESYGVEVKTPARSLSAMAATVAKSSDPADPPIPNDSRILFKEPVSSYKGEYPYVHTMETESGHIQEFDDTPGQERYRLVHPTGTYEEVSPSGRRTRKTVDNLYDITNADGNFLVAGDKKTNVGGSEIYYNMDNRLHQIDGSNTIFVRGDETKTVEGNGTILVKGNVTIIVEGNADITVKGDATTLVEGNQTNTVNGNLSWKVAGTVDWDVGGDWTEKMASMSSISSGQYTIDGSRIDIG
What is the function of this protein?
Baseplate central spike complex-associated lysozyme that is essential for the localized hydrolysis of bacterial cell wall, so that the tail tube, through which the phage DNA is ejected, can penetrate to the host inner membrane (PubMed:21129200, PubMed:21793574, PubMed:16956798, PubMed:3157805).  The tail lysozyme complex at the tip of the tail tube penetrates through the outer membrane into the periplasm and during that process, gp5* dissociates from gp5C and activated (PubMed:16956798).  Due to the lower pH in the periplasm, gp5* would dissociate from gp27 which probably still binds to the tip of the tube (PubMed:16956798).  This way, lysozyme domain is released and locally digests the peptidoglycan layer to make a hole to let the tube penetrate to the inner membrane (PubMed:16956798).  Involved in the tail assembly (PubMed:21129200).
What are the official names of this protein?
Pre-baseplate central spike protein Gp5, Pre-Gp5, Peptidoglycan hydrolase gp5.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 24 family.
What are the subcellular locations of this protein?
[Baseplate central spike protein Gp5*]: Virion. Note=Present in 3 copies in the baseplate. SUBCELLULAR LOCATION: [Gp5C]: Virion. Note=Present in 3 copies in the baseplate. SUBCELLULAR LOCATION: [Pre-baseplate central spike protein Gp5]: Virion. Note=Present in the baseplate.
Protein: PYRB_BACVZ
Sequence: MNHLTAMSELSAAEITELLREAKAIKEGTVRHDLAGKFVANLFFEPSTRTRFSFEVAEKKLGMNVLSLDDTSTSVQKGESLYDTVKTLESIGADACVIRHSTDEYYKDLTGRVNIPILNAGDGCGQHPTQSLLDLMTIQEEFETFQGLTVSIHGDIKHSRVARSNAEVLTRLGARVLFSGPPQWQDEKNAFGTCVQTDEAIQASDVVMLLRIQNERHQTEADQKGYLEAYGLTAKRAESMKRHAIIMHPAPVNRGVEIDTTLVECGKSRIFKQMENGVYIRMAVLKRALQTNVKRGEAAYVLSH
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TIG_XANCB
Sequence: MQASIESTGNLERRLTFTLPQERLETHVGGRLRELARTTRIKGFRPGKVPTKVIEQRFGQQVRAEAMEGLLRETFDSAVREHSLRLAGNPRIDQGESDFDFVATFEVVPDFGDIDVTNLSVVRHTAEVTDADIDQMIENLRLQRRTWNPVERGAQVGDLVALETWSQAGNERLPAEGVETGSSVLGSGVMFDQIEKGLEGLSKGEDKALSIDFPADWRVPQLAGKTVQVHVKAVEVSEPVLPEVNKEFIKSFGVKSGDAEQFRADIRTNLERELKGALMNRLRREVGEQLIAAYAHVEMPPRLVENEARSMLAQQVDQMRRSGRNPGEIPADAHQGFMDAAAKRVLVGLLVGEVARRNELRLESKRVSETLRLIASTYEEPEQVIEMYRNDPQLMSGLRSRVMEEQVIDWIAERAKHTEQSLSFQDAIRV
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PEPB_ECOHS
Sequence: MTEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKIDGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVEWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGEDLREQGYMGLHTVGRGSERSPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPEMIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASAAQENEPFWRLPLAEFHRSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_STRT1
Sequence: MVMTDPIADFLTRIRNANQAKHEVLEVPASNIKKGIAEILKREGFVKNVEVIEDDKQGIIRVFLKYGQNGERVITNLKRISKPGLRVYSKREDIPKVLNGLGIAIISTSEGLLTDKEARQKNVGGEVIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NADK_BACFN
Sequence: MKFAIFGNTYQAKKSSHAATLFKLLEKHGAEICVCREFHRFLKSDLKLNVKADDLFDENNFDADMVISIGGDGTFLKAARRVGNKGIPILGINTGRLGFLADVSPEEMEETIEEVYQNHYTVEERSVLQLLCDDKHLQNSPYALNEIAILKRDSSSMISIRTAINGAHLTTYQADGLIIATPTGSTAYSLSVGGPIIVPHSKTIAITPVAPHSLNVRPIVICDDWEITLDVESRSHNFLVAIDGSSETCKETTRLTIRRADYSIKVVKRFNHIFFDTLRTKMMWGADSRV
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIF4_ARATH
Sequence: MEHQGWSFEENYSLSTNRRSIRPQDELVELLWRDGQVVLQSQTHREQTQTQKQDHHEEALRSSTFLEDQETVSWIQYPPDEDPFEPDDFSSHFFSTMDPLQRPTSETVKPKSSPEPPQVMVKPKACPDPPPQVMPPPKFRLTNSSSGIRETEMEQYSVTTVGPSHCGSNPSQNDLDVSMSHDRSKNIEEKLNPNASSSSGGSSGCSFGKDIKEMASGRCITTDRKRKRINHTDESVSLSDAIGNKSNQRSGSNRRSRAAEVHNLSERRRRDRINERMKALQELIPHCSKTDKASILDEAIDYLKSLQLQLQVMWMGSGMAAAAASAPMMFPGVQPQQFIRQIQSPVQLPRFPVMDQSAIQNNPGLVCQNPVQNQIISDRFARYIGGFPHMQAATQMQPMEMLRFSSPAGQQSQQPSSVPTKTTDGSRLDH
What is the function of this protein?
Transcription factor acting negatively in the phytochrome B signaling pathway.  May regulate the expression of a subset of genes involved in cell expansion by binding to the G-box motif (By similarity).  Activated by CRY1 and CRY2 in response to low blue light (LBL) by direct binding at chromatin on E-box variant 5'-CA[CT]GTG-3' to stimulate specific gene expression to adapt global physiology (e. g.  hypocotyl elongation in low blue light) (PubMed:26724867).
What are the official names of this protein?
Transcription factor PIF4, Basic helix-loop-helix protein 9, AtbHLH9, bHLH 9, Phytochrome-interacting factor 4, Short under red-light 2, Transcription factor EN 102, bHLH transcription factor bHLH009.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family.
Protein: TPPG_ARATH
Sequence: MDLNINKTTPVLSDPTTPVSKTRLGSSFPSGRFMMNSRKKIPKLDDVRSNGWLDAMISSSPPRKRLVKDFNIEIAPEDDFSQRAWMLKYPSAITSFAHIAAQAKNKKIAVFLDYDGTLSPIVDDPDRAIMSDAMRAAVKDVAKYFPTAIISGRSRDKVYQLVGLTELYYAGSHGMDIMTPVNPNGSPEDPNCIKTTDQQGEEVNLFQPAKEFIPVIEEVYNNLVEITKCIKGAKVENHKFCTSVHYRNVDEKDWPLVAQRVHDHLKRYPRLRITHGRKVLEVRPVIEWNKGKAVEFLLESLGLSNNDEFLPIFIGDDKTDEDAFKVLREGNRGFGILVSSVPKESNAFYSLRDPSEVKKFLKTLVKWGKMESSKTSF
What is the function of this protein?
Removes the phosphate from trehalose 6-phosphate to produce free trehalose.  Trehalose accumulation in plant may improve abiotic stress tolerance (By similarity).
What are the official names of this protein?
Probable trehalose-phosphate phosphatase G, AtTPPG, Trehalose 6-phosphate phosphatase, Trehalose-phosphate phosphatase 6.
What is the protein family that this protein belongs to?
Belongs to the trehalose phosphatase family.
Protein: SP5G_CLOPE
Sequence: MNITDVRIRKISAEGKMKAIVSVTFENQFVVHDIKVIEGQNGLFIAMPSRKTPDGEFKDIAHPINTETREQIQKAILDEYEKVKNLDVQE
What is the function of this protein?
Could be involved in septation.
What are the official names of this protein?
Putative septation protein SpoVG.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: MT_PLEAT
Sequence: MDPCECSKTGSCNCGGNCSCTNCACTSCKKTSCCSCCPAGCSKCASGCVCKGKTCDKTCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein, MT.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: MIB1_HUMAN
Sequence: MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins.  Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.  Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity).  Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells.  Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
What are the official names of this protein?
E3 ubiquitin-protein ligase MIB1, DAPK-interacting protein 1, DIP-1, Mind bomb homolog 1, RING-type E3 ubiquitin transferase MIB1, Zinc finger ZZ type with ankyrin repeat domain protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell membrane. Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.
Protein: RL22_LEUCK
Sequence: MAEQITSARATAKIVRVAPRKARLVLDTIRRKSVNEAYAILKFLPNTSTEDIYKVLNSAVANAENNFSLDREDLIVKEAFANEGPTLKRFRPRAKGSASPINKRTSHITIVVAEKEAK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CSPLC_SELML
Sequence: MGVASQSSVANEAGAAPEASIQQTLRGFSSPTSLLLRIATAVLCTLTLAFLVTSKERKEIASIDIVAIWSNSKALIFLAVVSGICLGYSLLHAAVFLVMLSGNRKPLARKKALDWMVFLADQVFFKIFCWFSIRVSSRRSKAGFV
What are the official names of this protein?
CASP-like protein SELMODRAFT_406854.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL4_PROM4
Sequence: MANCVVLDWQGQEAGKATLDLKVAKETTAVDLIHRAVVRQQAHSRQGTASTLTRSEVRGGGRKPYKQKGTGRARQGSIRTPLRPGGGIIFGPKPRSFSLGMNRKERRLALRTALMARINDLMIVQDFGTALKVPKTREIVEALSRFGIADDAKVLIILAQPSEIIIRSVRNIERVKVIGADQLNVFDLLNANSLVIGEKALSTIKEVYGDD
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RL27_CERS4
Sequence: MAHKKAGGSSRNGRDSAGRRLGVKLYGGQAAIPGNIIVRQRGTTWFPGAGVGMGRDHTIFATVEGRVEFRKGLKGRTFISVLPTAEAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RS3_STAEQ
Sequence: MGQKINPIGLRVGVIRDWEAKWYAEKDFASLLHEDLKIRKFIDNELKEASVSHVDIERAANRINIAIHTGKPGMVIGKGGSEIEKLRNKLNTLTDKKVHINVIEIKKIDIDARLVAENIARQLENRASFRRVQKQAITRAMKNGAKGIKTQVSGRLGGADIARAEQYSEGTVPLHTLRADIDYAHAEADTTYGKLGVKVWIYRGEVLPTKNTSEGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: HKS_HELSS
Sequence: GPPYQPLVPR
What is the function of this protein?
Helokinestatin antagonizes the vasodilatory actions of bradykinin at the B2 bradykinin receptor (BDKRB2) in a dose-dependent manner.
What are the official names of this protein?
Helokinestatin-1.
What are the subcellular locations of this protein?
Secreted.
Protein: GON1_CHICK
Sequence: MEKSRKILVGVLLFTASVAICLAQHWSYGLQPGGKRNAENLVESFQEIANEMESLGEGQKAECPGSYQHPRLSDLKETMASLIEGEARRKEI
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Progonadoliberin-1, Progonadoliberin I.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: VES_SHIF8
Sequence: MEYFDMRKMSVNLWRNAAGETREICTFPPAKRDFYWRASIASIAANGEFSLFPGMERIVTLLEGGEMLLESADRFNHTLKPLQPFAFTADQVVKAKLTAGQMSMDFNIMTRLDVCKAKVRIAERTFTTFGSRGGVVFVINGAWQLGDKLLTTDQGACWFDGRHTLRLLQPQGKLLFSEINWLAGHSPDQVQ
What are the official names of this protein?
Protein Ves.
What is the protein family that this protein belongs to?
Belongs to the Ves family.
Protein: PUR7_PSEP1
Sequence: MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEEAGVPTQFDKLLGDNECLVKKLDMIPVECVVRNYAAGSLVKRLGVEEGIKLEPSTFELFLKNDEKGDPFINESHVVAFGWGTAEQLVEMKKLSLKVNEVLSKLFDDAGLLLVDFKLEFGVFHGQIVLGDEFSPDGCRLWDKETRKKMDKDRFRQGLGDVIEAYEEVAKRLGVPL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.