PharMolix/UniProtQA huggingface dataset:
Protein: NOP8_YEAST
Sequence: MDSVIQKRIFVGNIFHNADDCYSELLDRFGKFGDCQDFQFEKHNHFAFIDIRFNDEADFNKLRKSFNNVKFKGNILKVDEAKPNWESTWAVQHAKDLKEDIILNAKMKKKNWQHYKKMENVAKSWKDHKEVIAGRMREAPRKRSQLRNITFRINVNGSLKVYKCYKTKLWGYERNKELNDLVYKFTNNFWKNGYNHIVDRLDYSRAVKTVRFKNGLKQLTVSKDENVCSGEMDSDENMSEEEKEKNNVILNDLLKDFDFDKPMTLNDSDEELLTEQRKGEEEEEEEEEKEVNAPEYENVNKTKDQSTLPQEKPEERKEQDEGDGQEDNEFIPTFTKEIGQGTISNTETLRNLFNPNEAEPVSQFKLIEDSDNDIDHAKDVDVNQLEEEVSKSSDTLGLTSAPVPHVSRDKDNKNFLFFPHLQSPFLVGQTQLSKVRAPGRETMLSNWDEEFWANRGNWTRDMRRKMKDALKHRKRKQSKSGLLL
What is the function of this protein?
Required for 60S ribosomal subunit synthesis.  May be involved in assembly reactions occurring within late pre-ribosomal particles.
What are the official names of this protein?
60S ribosome subunit biogenesis protein NOP8, Nucleolar protein 8.
Protein: EX7S_RHOPT
Sequence: MAEAATTDVKKLSFERALEELETIVKRLEDGKVPLEESVTIYERGEALKRRCEDLLRQAEARVDKITTDAQGAPTGTEPLDVQ
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y240_IDILO
Sequence: MSVKEWPVSERPREKLQTQGAEYLSDAELLAILLGSGSGGQDVVSFARRLLSDFGGVGALLTATPEQLLACNGIGPARVNQLRVVLELSRRYLKWQLERSDGFTEPTMVKDYLTSQLRHQGREVFAILLLDSQHRLLRYEELFQGTINAAPVYPREVIKLVMQYNAAAVILAHNHPSGVAEPSQADQRVTERVKKALTLIDVALLDHFVVGAGDPISFAERGLL
What are the official names of this protein?
UPF0758 protein IL0240.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: GSA_ARCFU
Sequence: MKLDKSRKLYAEALNLMPGGVSSPVRAFKPHPFYTARGKGSKIYDVDGNAYIDYCMAYGPLVLGHANEVVKNALAEQLERGWLYGTPIELEIEYAKLIQKYFPSMEMLRFVNTGSEATMAALRVARGFTGRDKIVKVEGSFHGAHDAVLVKAGSGATTHGIPNSAGVPADFVKNTLQVPFNDIEALSEILEKNEVAALILEPVMGNSSLILPEKDYLKEVRKVTAENDVLLIFDEVITGFRVSMGGAQEYYGVKPDLTTLGKIAGGGLPIGIFGGRKEIMERVAPSGDVYQAGTFSGNPLSLTAGYATVKFMEENGVIEKVNSLTEKLVSGIADVLEDKKAECEVGSLASMFCIYFGPTPRNYAEALQLNKERFMEFFWRMLENGVFLPPSQYETCFVSFAHTEEDVEKTVEAVSESL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_LAWIP
Sequence: MSQMTYKRVLLKLSGESLAGRQLTGIDPDTVAVLCNELSSVIELGLQIALVIGGGNIFRGLSASAKGMDRSSADYMGMLATVLNALAIQDTLEKKGHPTRVLSAIAMQEVCEPYVRRRAMRHLEKGRVIICAAGTGNPYFTTDTAAALRCMELKCDALIKATRVDGVYDKDPLKFDDAEMFKHLTYEETLRRHIKIMDSTAITLAQENNIPIIVCNMFNGSIKRAILGQNPGTTVEGE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_NEOYE
Sequence: MNNIVKIPQIITILSEHSSEHKFGFNSDIFEANVINILLLLFGLIYVLKQFLGSSLNARQIKVLAAIQESEERLEQASARLSESEKQLAQTQIIIDQIKKEAQLTAGKVRSSILAQGQLDIERLAITGKSNIETAEKQIRRQIQQQITFLALKRVTLQLENQMSSEMQLRIIDNNIAKLGDQL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: AAEB_SALPA
Sequence: MGIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIAALIIIISMIRAPLLMILVCCVWVGFCTWISSLVRIENSYAWGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCAILADLLFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKALNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGERETPVTLYSWVGAATRYLLLKRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGNGEMVMIAVVTSLAMRLPNPRMVCIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVISAGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKRLTGMLHKYQNALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OTCC_PSEAE
Sequence: MAFNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSDKPLHDISYAYLGDARNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPVEAWGERIKELLPYQVNMEIMKATGNPRAKFMHCLPAFHNSETKVGKQIAEQYPNLANGIEVTEDVFESPYNIAFEQAENRMHTIKAILVSTLADI
What is the function of this protein?
Involved in the catabolism of arginine.  Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP (PubMed:4962140, PubMed:2118516).  This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate (PubMed:2118516).
What are the official names of this protein?
Ornithine carbamoyltransferase, catabolic, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YF69_SCHPO
Sequence: MDEELQAIRQARLAQLQAEHGSAPSNIASGPSSNQQQQEVQDEMRQNLLSQILEHPARDRLRRIALVRKDRAEAVEELLLRMAKTGQISHKISEPELIELLEKISGEVSKRNETKIVINRRVQDDEDDWDL
What are the official names of this protein?
Uncharacterized protein C23C4.09c.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: FADA_SHIFL
Sequence: MEQVVIVDAIRTPMGRSKGGAFRNVRAEDLSAHLMRSLLARNPALEAAALDDIYWGCVQQTLEQGFNIARNAALLAEVPHSVPAVTVNRLCGSSMQALHDAARMIMTGDAQACLVGGVEHIGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLARMHGISREMQDAFAARSHARAWAATQSAAFKNEIIPTGGHDADGVLKQFNYDEVIRPETTVEALATLRPAFDPVNGTVTAGTSSALSDGAAAMLVMSESRAHELGLKPRARVRSMAVVGCDPSIMGYGPVPASKLALKKAGLSASDIGVFEMNEAFAAQILPCIKDLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLLNLMERKDVQFGLATMCIGLGQGIATVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.  Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity).
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNAI_BACSU
Sequence: MKLYNEFINIAKTFNKELDIIPLLYGSLGLEKVTGLDFSPEDIDLLIPLIFLEEKWEKLKKVMELHGYKMVDLHEHEFKKTNTKIGISYIEDLKPFADVDYNNLEIFEDGGAKYHLLTIDDYLKIYKKSLLDGYRRRKKNHKDQSKINILNKLIRN
What are the official names of this protein?
Uncharacterized protein YnaI.
What is the protein family that this protein belongs to?
To L.lactis TrpF C-terminal region.
Protein: TSAB1_COMTE
Sequence: MSADVPVTVAAVRAVARDVLALELRHANGQPLPGASAGAHIDLALPNGLVRQYSLVNATGQATMDCYQVAVGWDANSRGGSVWIHEKLKVGQALRVTHRATCSEMAPEHRRVLLLAGGIGVTPIYAMAQACAQQGVDVELWASARSAPRLAYLEELKALLGQRLHLHADDEQGGPMNLTERLATQRWDAVYACGPAPMLDALTAATAHWAPGSVRMERFKGAEQPASERQPFELVLQRAGLSTTVDAHESVLDAMERVGVDFPWSCREGICGTCEAPVLEGEVQHLDYVLSPEERAEQRRMMVCVSRCGGGRLVLDI
What is the function of this protein?
Iron-sulfur flavoprotein carrying electrons from NADH to the oxygenase TsaM.  Involved in the toluene-4-sulfonate degradation pathway.
What are the official names of this protein?
Toluene-4-sulfonate monooxygenase system reductase subunit TsaB1, TS methylmonooxygenase system, reductase B, Toluenesulfonate methyl-monooxygenase reductase component TsaB1.
Protein: RNH2_RUMCH
Sequence: MGTLTLKQIQEEAQKLSIQEAIEYLSTLHSTGFKVDKLLEKYYRLKNKHDREMERLQKMLSFERQAISEGFNYIAGVDEAGRGPLAGPVVAAAVVLPNGLTIEGINDSKKLSESQREKLFSEIKEKALSYGISVIDEKYIDEVNILNATKRAMTEALSQLEPTADCILLDAVRLDNISTKQVPIIKGDSLSLSIAAASILAKVTRDRLLTEYDAKYPQYGFAAHKGYGTPQHISAIKKFGLCPIHRLSFVKNFVE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_BUCBP
Sequence: MKIRPLHDRVIVKRKEAESKSAGGIVLTGSAAGKSTRGTVIAVGNGRILDNGNLKSLDVKVGDTVIFNEGYGAKVEKIDNEELLILTESDILAIVEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_STRZT
Sequence: MKEIIEKLAKFENLSGVEMTDVIERIVTGRVTEAQIASLLLALKMKGETPEERTAIAQVMRGHAQHIPTEIHDAMDNCGTGGDKSFSFNISTTAAFVLAGGGIHMAKHGNRSISSKSGSADVLEALGINLDLKPAELGKVFDKTGIVFLFAKNMHPAMKYIMPARLELGIPTIMNLTGPLIHPMALETQLLGISRPELLESTAQVLKNMGRKRAIVVAGPEGLDEAGLNGTTKIALLENGEISLSSFTPEDLGMEDYAMEDIRGGNAQENAEILLSVLKNEASPFLETTVLNAGLGFYANGKIDSIKEGVALARQVIARGKALEKLRLLQEYQK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: B3GT1_PANTR
Sequence: MASKVSCLYVLTVVCWASALWYLSITRPTSSYTGSKPFSHLTVARKNFTFGNIRTRPINPHSFEFLINEPNKCEKNIPFLVILISTTHKEFDARQAIRETWGDENNFKGIKIATLFLLGKNADPVLNQMVEQESQIFHDIIVEDFIDSYHNLTLKTLMGMRWVATFCSKAKYVMKTDSDIFVNMDNLIYKLLKPSTKPRRRYFTGYVINGGPIRDVRSKWYMPRDLYPDSNYPPFCSGTGYIFSADVAELIYKTSLHTRLLHLEDVYVGLCLRKLGIHPFQNSGFNHWKMAYSLCRYRRVITVHQISPEEMHRIWNDMSSKKHLRC
What is the function of this protein?
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue.  Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins.
What are the official names of this protein?
Beta-1,3-galactosyltransferase 1, Beta-1,3-GalTase 1, Beta3Gal-T1, Beta3GalT1, UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: RBT4_CANAL
Sequence: MKFSQVATTAAIFAGLTTAEIAYVTQTRGVTVGETATVATTVTVGATVTGGDQGQDQVQQSAAPEAGDIQQSAVPEADDIQQSAVPEAEPTADADGGNGIAITEVFTTTIMGQEIVYSGVYYSYGEEHTYGDVQVQTLTIGGGGFPSDDQYPTTEVSAEASPSAVTTSSAVATPDAKVPDSTKDASQPAATTASGSSSGSNDFSGVKDTQFAQQILDAHNKKRARHGVPDLTWDATVYEYAQKFADQYSCSGNLQHSGGKYGENLAVGYADGAAALQAWYEEAGKDGLSYSYGSSSVYNHFTQVVWKSTTKLGCAYKDCRAQNWGLYVVCSYDPAGNVMGTDPKTGKSYMAENVLRPQ
What is the function of this protein?
Secreted protein that acts as a virulence factor during infections such as in posttraumatic corneal infections.  Acts as an important antigen in patients with systemic candidiasis and plays a role in the protection against phagocyte attack.
What are the official names of this protein?
Secreted protein RBT4, PRY family protein 4, Repressed by TUP1 protein 4.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: YH56_SCHPO
Sequence: MVSFCCEVCQDIIKKPKLDQHRSRCHGAYFTCIDCNTTFERTDYRNHTSCMTEAQRYQKGLYRPTKKELKKAKMNGNAVNSKELSPNTDNQNTPAGPTKHSLDENEKDKENKKSKKETVSSPAEQLLALTQNQEISLYKLLKKYNKQASKEDSLDSKEVLKHLAITADAKGNYLVKPITK
What are the official names of this protein?
UPF0743 protein C215.06c.
What is the protein family that this protein belongs to?
Belongs to the UPF0743 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTNW_BACAA
Sequence: MSGIIATYLIHDDSHNLEKKAEQIALGLTIGSWTHLPHLLQEQLKQHKGNVLHVEELAEHEHTNSYLRKKVKRGIIKIEYPLLNFSPDLPAILTTTFGKLSLDGEVKLIDLTFSDELKKHFPGPKFGIDGIRNLLQVHDRPLLMSIFKGMIGRNIGYLKTQLRDQAIGGVDIVKDDEILFENALTPLTNRIVSGKEVLQSVYETYGHKTLYAVNVTGRTFDLKENAKRAVQAGADILLFNVFAYGLDVLQSLAEDDEIPVPIMAHPAVSGAYSASKLYGISSPLLLGKLLRYAGADFSLFPSPYGSVALEKEEALAISKYLTEDDVFFKKSFSVPSAGIHPGFVPFIIRDFGKDVVINAGGGIHGHPNGAQGGGKAFRTAIDATLQNKPLHEVDDINLHSALQIWGNPSHEVKL
What is the function of this protein?
Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P).
What are the official names of this protein?
2,3-diketo-5-methylthiopentyl-1-phosphate enolase, DK-MTP-1-P enolase, RuBisCO-like protein, RLP.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type IV subfamily.
Protein: AMIE_BACSP
Sequence: MRHGDISSSHDTVGIAVVNYKMPRLHTKAEVIENAKKIADMVVGMKQGLPGMDLVVFPEYSTMGIMYDQDEMFATAASIPGEETAIFAEACKKADTWGVFSLTGEKHEDHPNKAPYNTLVLINNKGEIVQKYRKIIPWCPIEGWYPGDTTYVTEGPKGLKISLIVCDDGNYPEIWRDCAMKGAELIVRCQGYMYPAKEQQIMMAKAMAWANNTYVAVANATGFDGVYSYFGHSAIIGFDGRTLGECGTEENGIQYAEVSISQIRDFRKNAQSQNHLFKLLHRGYTGLINSGEGDRGVAECPFDFYRTWVLDAEKARENVEKITRSTVGTAECPIQGIPNEGKTKEIGV
What is the function of this protein?
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.
What are the official names of this protein?
Aliphatic amidase, Acylamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: RATB_ECOLI
Sequence: MPGKIAVEVAYALPEKQYLQRVTLQEGATVEEAIRASGLLELRTDIDLTKNKVGIYSRPAKLSDSVHDGDRVEIYRPLIADPKELRRQRAEKSANK
What is the function of this protein?
Does not function as an antitoxin to the upstream RatA toxin.
What are the official names of this protein?
UPF0125 protein RatB.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: TPCJ_ASPFU
Sequence: MITVIKWLVSGCCALAAVTTRAPLPKDCRNTPNSRGCWKDGFDILTDYTDPKRAPPGKLVEYNLTVSQQVIAPDGYEKLGMVANGQFPGPTIEADWGDTIRISVYNNFTDNNNGSAIHWHGLRQFENNVQDGVPGVTQCPSKPGETQVYEFRATQYGTSWYHSHFSLQCECPLNGLFGPIVIHGPSSMDWDEDLGPWLLHDWYHDDVFSLLWVGETKNRGAIPESTILNGKGKFDCNHHNDTRCTGTGGEYFEVNFRKGVRYKFTIANTGTLLEYMFWIDGHNLTVIAADFVPIEPYVTDVVNVAMGQRYEIIVEANADFTHGSNFWIYAQYCDEVDLLPHKAVGIVRYDEQDRQDPRTPPLSDQHRDFGCEDPDLDNLVPVVQQSVGRRVNRMEMKDYLRMGQEGYPDPMNFDGDLHKWVLGDVPMFVDWKNPSLKKLAVDEHPDFPPETVPILLDFDTGDWVHFVITNNYTFEKVHFPRNLTPVMHPMHLHGHDFAILAQGRGEFDPSIVPKLDNPPRRDVVNVDTGSYVWIAFQVNNPGAWLLHCHIAFHVSSGLSLQFIEQPKKVKPLMEAAGVLGEFHDRCAKWTEYYDSVNIPDNHTIDDSGI
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process (PubMed:26278536, PubMed:26242966).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC (PubMed:26242966).  The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC (PubMed:26242966).  The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone (PubMed:26242966).  The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin (PubMed:26242966).  Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:26242966).  Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity).  Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH.  Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin (PubMed:26242966).  Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death (PubMed:22319557).  The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway (PubMed:26242966).
What are the official names of this protein?
Oxidoreductase tpcJ, Trypacidin synthesis protein J.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
Protein: PSAJ_DRIGR
Sequence: MRDIKTYLSVAPVLTTLWFGSLAGLLIEINRLFPDALTFSFFSF
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: TGT_XANOP
Sequence: MSRLQFQLQATDGHARRGRLTFPRGTVETPAFMPVGTYGSVKGILPEHIRALGAEIILGNTFHLYLRPGLDVIGDHGGLHGFARWDGPILTDSGGFQVFSLAHRRKITEQGVTFSSPTDGARVFLGPEESMKIQKVLDSDIVMIFDECTPYPATEDLARRSMELSLRWAQRSRDAHDGLGNDAALFGIVQGGVHPDLRSRSLDGLQSIGFDGYAIGGLAVGEPEHERNAMLEHLHPRLPAECPRYLMGVGRPEDLVEGVARGVDMFDCVMPTRNARNGHYFTSFGTVRIRNAKYERDLDTIEPGCGCHACSSGYTRSYLRHLDRCNEMLAPMLGTLHNLWYYEKLMADMRAAIASGTFVEFRRSFYAARGATTPPLPGETS
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: KAD2_ASPNC
Sequence: MAPITDEVVNGLKDTIGKLEARVEELEGRLSNQVKPKSVAEQMRIILMGPPGAGKGTQAPRLKEKYCVCHLATGDMLRSQVAKKTALGKEAKKIMDQGGLVSDEIMVNMIQSELDNNAECKNGFILDGFPRTVAQAERLDDMLNARQQKLQHAVELQIDDALLVARITGRLVHPASGRSYHKIFNPPKEEMKDDVTGEPLIQRSDDNADTLKKRLGTYHAQTAPVVEYYKKTGIWRGIDASQEPGQVWKSLLGVFRQN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: RR4_NASOF
Sequence: MSRYRGPRFKKIRRLGALPGLTSKRPKAGSDLRNQSRSGKKSQYRIRLEEKQKLRFHYGLTERQLLKYVRIAGKAKGSTGQVLLQLLEMRLDNILFRLGMALTIPQARQLVNHGHILVNGRIVDIPSYRCKPRDIITVKDEQNSRTLVQNLLDSSAPEELPNHLTLHTFQYEGLVNQIIDRKCVGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UBC30_ARATH
Sequence: MASKRINKELRDLQRDPPVSCSAGPTGDDMFQWQATIMGPADSPFAGGVFLVTIHFPPDYPFKPPKVAFRTKVYHPNINSNGSICLDILKEQWSPALTVSKVLLSICSLLTDPNPDDPLVPEIAHIYKTDRVKYESTAQSWTQKYAMG
What is the function of this protein?
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 30, E2 ubiquitin-conjugating enzyme 30, Ubiquitin carrier protein 30.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: RPO11_PYRAE
Sequence: MSPVLRLEILKLDDKYLELKAKGETYTLFSPLVEYLSNDPDVEYVQFDVDHPLQENAYFKLKVKRGNPLEAIQRAVNAILSDLEELERGFFS
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit L.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTH_MYCTO
Sequence: MAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPIGGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIAIGFTASFFVVTPPPNAVLGGLAPRFQGTESVLLAAAIMGATVMPHAVYLHSGLARDRHGHPDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTASIEGAYHAVHDTLGATIAVLFAVGLLASGLASSSVGAYAGAMIMQGLLHWSVPMLVRRLITLGPALAILTLGFDPTRTLVLSQVVLSFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLNVMLIYLTVTG
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.  Transports zinc and iron.  Can also interact with manganese and copper (By similarity).
What are the official names of this protein?
Divalent metal cation transporter MntH, Mramp.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.