PharMolix/UniProtQA huggingface dataset:
Protein: SSB_PROMI
Sequence: MASRGVNKVILIGNLGQDPEIRYMPSGGAVANLTLATSESWRDKQTGEMKEKTEWHRVVIFGKLAEIAGEYLRKGSQVYIEGQLQTRKWQDQSGQDRYSTEVVVNIGGTMQMLGGRGGQDNAPSQGQGGWGQPQQPQASQQFSGGAPSRPAQQPAAAPAPSNEPPMDFDDDIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism (Probable).
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: HISZ_NITMU
Sequence: MNMSAWALPEYIEDILPAEALKIEMMRRRVLDWLFVNGYELVGPPLLEYVESLLTGSGGQMNLRVLKVVDQLSGRMMGLRADMTPQVARIDAHLLNRKGITRLCYAGSVLHARPSGLTRTREPLQIGAELYGHQGLESDLEIQRLMLQSLAIAGVGNIHLDLGHVAVFRGLIRSTGISPDLEMELSGALQGKDKAALKELCAGLKKQVDASVREALQLLPELYGDENVLTLARSALPSYPGIMKALDELEMVASELSPLVDTLAFDLADLRGYHYHSGMVFAAYTDNCPNAIAVGGRYDEVGKAFGRARPATGFSMDLRELSGLMSSDSHPRGILAPFIKEDKALEKKIEQLRNEGQIVIVALPGHENDAGSFNCDKKLVSENGVWSIADALI
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASPP_AEDAE
Sequence: MLIKSIIALVCLAVLAQADFVRVQLHKTESARQHFRNVDTEIKQLRLKYNAVSGPVPEPLSNYLDAQYYGAITIGTPPQSFKVVFDTGSSNLWVPSKECSFTNIACLMHNKYNAKKSSTFEKNGTAFHIQYGSGSLSGYLSTDTVGLGGVSVTKQTFAEAINEPGLVFVAAKFDGILGLGYSSISVDGVVPVFYNMFNQGLIDAPVFSFYLNRDPSAAEGGEIIFGGSDSNKYTGDFTYLSVDRKAYWQFKMDSVKVGDTEFCNNGCEAIADTGTSLIAGPVSEVTAINKAIGGTPIMNGEYMVDCSLIPKLPKISFVLGGKSFDLEGADYVLRVAQMGKTICLSGFMGIDIPPPNGPLWILGDVFIGKYYTEFDMGNDRVGFATAV
What is the function of this protein?
May degrade organelles involved in the biosynthesis and secretion of vitellogenin.
What are the official names of this protein?
Lysosomal aspartic protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: HS181_ORYSJ
Sequence: MSLIRRSNVFDPFSLDLWDPFDGFPFGSGSRSSGSIFPSFPRGTSSETAAFAGARIDWKETPEAHVFKADVPGLKKEEVKVEVEDGNVLQISGERSKEQEEKTDKWHRVERSSGKFLRRFRLPENTKPEQIKASMENGVLTVTVPKEEPKKPDVKSIQVTG
What are the official names of this protein?
18.1 kDa class I heat shock protein, 18.1 kDa heat shock protein, OsHsp18.1.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_BIFLS
Sequence: MSTIPFSPKQKPDESTLTDRQRKVLDAIRTHIDEQGFAPSFREIGNAAGLKSPSSVKHQLQVLEDKGFIRMNANKGRAIEVVAGSAPNPEKPSQASEEATSTSNVAEIYQFPAEAIAESHDVPLVGRIAAGVPITAEQHVDDVMRLPERLTGSGTLFMLEVHGDSMVDAAICDGDYVVVREQNSAVNGDIVAALLDDEATVKTFRKENGHVWLMPHNPAYSPIDGTHATIMGKVVTVLRKL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: EFTS_VIBCH
Sequence: MAVTAALVKELRERTGAGMMECKKALVETNGDIELAIENMRKSGAAKAAKKAGNIAAEGTIMIKEGEGIAALVEVNCQTDFVAKDSNFVAFANQVTDAALASKASVEELQAQFEEARVALVAKIGENINIRRVQYVEGEALATYRHGDRIGVVVAGSADVETLKHVAMHVAASRPEFLTPDDVPAEVVAKEREVQVGIAMNEGKSKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPKKTVGEILAEKGATVSAFIRLEVGEGIEKQEGLSFAEEVALAQKG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_SHEFN
Sequence: MQNQRIRIRLKGFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRKERYTVLISPHVNKDARDQYEIRTHKRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RL1_CAMHC
Sequence: MAKNSKRFNELLKKVDDSKIYNINEAVETVKTLASAKFDETVEISLKLNVDPKYADQMVRGSVVLPAGTGKKVRVAVIAKDAKADEAKNAGADIVGSEELIEEIQKGNINFDVLIATPNLMGLVGKVGRILGPKGIMPNPKTDTVTMDITNAVKNAKSGQVNFRVDKQGNINAGIGKVSFSKEQICNNLTTFIKEINKHKPATSKGRYIKSGALSLTMSPSLSLDTQELLDLK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: CARAD_PSERE
Sequence: MYQLKIEGQAPGTCGSGKSLLVSALANGIGFPYECASGGCGVCKFELLEGNVQSMWPDAPGLSSRDREKGNRHLACQCVALSDLRIKVAVQDKYVPTIPISRMEAEVVEVRALTHDLLSVRLRTDGPANFLPGQFCLVEAEQLPGVVRAYSMANLKNPEGIWEFYIKRVPTGRFSPWLFENRKEGARLFLTGPMGTSFFRPGTGRKSLCIGGGAGLSYAAAIARASMRETDKPVKLFYGSRTPRDAVRWIDIDIDEDKLEVVQAVTEDTDSLWQGPTGFIHQVVDAALLETLPEYEIYLAGPPPMVDATVRMLLGKGVPRDQIHFDAFF
What is the function of this protein?
Part of the multicomponent carbazole 1,9a-dioxygenase (CARDO), that converts carbazole (CAR) into 2-aminobiphenyl-2,3-diol.  It can use both NAD and NADP as electron donors, but NAD is supposed to be the physiological electron donor.
What are the official names of this protein?
Ferredoxin--NAD(P)(+) reductase CarAd, Carbazole 1,9a-dioxygenase, ferredoxin reductase component, CARDO.
Protein: UVRB_PECAS
Sequence: MSKAFTLNSDFKPAGDQPEAIRRLKEGLEDGLAHQTLLGVTGSGKTFTIANVIADLNRPTMMLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVIVVASVSAIYGLGDPDLYLKMMLHLTQGMLIDQRAILRRLAELQYARNDQAFQRGTFRVRGEVIDIFPAESDEIALRVELFDEEVERLSLFDPLTGHVLQTVPRYTIYPKTHYVTPRERILQAMEDIKVELADRKKVLLANDKLVEEQRLSQRTQFDLEMMNELGYCSGIENYSRYLSGRGPGEPPPTLFDYLPADGLLVIDESHVTVPQIGGMYRGDRARKETLVEYGFRLPSALDNRPMKFEEFEALAPQTIYVSATPSHYELEKSGGDVIDQVVRPTGLLDPIIEVRPVGTQVDDLLSEIRLRAAINERVLVTTLTKRMAEDLTEYLQEHGERVRYLHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLRGKAILYGDRITASMAKAISETERRREKQEAYNTEHGIVPQGINKKISDILQLGQSANKGKGRGNRKAAEPAARYELMTPKALELKIRELESKMLTHAQNLEFEEAAALRDEVQVLRAQFIAIS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTC_MYCTA
Sequence: MIRHFLRDDDLSPAEQAEVLELAAELKKDPVSRRPLQGPRGVAVIFDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDETLQDTAKVLSRYVDAIVWRTFGQERLDAMASVATVPVINALSDEFHPCQVLADLQTIAERKGALRGLRLSYFGDGANNMAHSLLLGGVTAGIHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLVTDTWTSMGQENDGLDRVKPFRPFQLNSRLLALADSDAIVLHCLPAHRGDEITDAVMDGPASAVWDEAENRLHAQKALLVWLLERS
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASP1_CUCME
Sequence: MKTGESTAIDIAPETNNSGPIGKKKSTTPLLAAPVPDRGTHRMKRGLAIFDFVLRIGVLASALAAAAAMGTSEQTLPFFTQFFQFEASYDDLPTFQFFVVAMAVVAGYVVLSIPFSIVCIIRPHAAGPRVLLLILDSVALTLNTAAAGAAAAVVSLAHSGNSSTNWLAICNQFGDFCQQASGAVVGSFAAVLLFLLLILFSALSLKNSH
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 1, CmCASP1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: RL7_METEP
Sequence: MADLAKIVEDLSSLTVLEAAELAKLLEEKWGVSAAAAVAVAAGPAAGAGAAAVEEQTEFTVVLASAGDKKIEVIKEVRAITGLGLKEAKDLVEGAPKPVKEGATKDEAEKLKAQLEKAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RRN7_YEAST
Sequence: MSTFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMEGDVEFNDDEDDLNGLGAGVITRRLNLTTNATGSFQSSQLTNSQLLQQQQRQSHKKFKKLIGHEAKLLFLKSFQFILKRQIRWLITEMRFPKEFEHVAKIIWLKILKTINDQPQEELKLQLHMTSTISILYLASTHLSLPVYTCDYIKWICTAKMPYFQASEILPKSWRIQLPNYYVSILEGSISPFNGQLYNKIALTCGMIHFKEFFNSEISCQGLLLKLVMQCALPPEFYFYTKQVIEFEETDIRNLTLWERTDERHTGRVSNHAELRVLSYFMLTINWMLSFDRDRQYPLKWILSLTESLTQRTTTSESIGRNIVKVVYPDKPTSSDYFQWSEEETLEFLKWMEKQFLPTQTKSLHNENGSMEMTIDQKIARRKLYKIFPLDREANHDGEFNDSTHQLTFIEDLQERYAKQTPFFESNKIRDSLNYQEANPPARKEAIGRLLTHIASQLLVDFAISKEQLKDCISRIKNACLHRMN
What is the function of this protein?
Component of RNA polymerase I core factor complex (CF) that acts as a SUA7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription.  Binds rDNA promoters and plays a role in Pol I recruitment.  After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a pre-initiation complex.
What are the official names of this protein?
RNA polymerase I-specific transcription initiation factor RRN7.
What is the protein family that this protein belongs to?
Belongs to the RRN7/TAF1B family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HSLU_ECOL5
Sequence: MSEMTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNNWGQTEQQQEPSAARQAFRKKLREGQLDDKEIEIDLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDAMKLLIEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNESTENIGARRLHTVLERLMEEISYDASDLSGQTITIDADYVSKHLDALVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Heat shock protein HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIM3A_HUMAN
Sequence: MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHMSLHGH
What is the function of this protein?
Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development.
What are the official names of this protein?
RIMS-binding protein 3A, RIM-BP3.A, RIMS-binding protein 3.1, RIM-BP3.1.
What is the protein family that this protein belongs to?
Belongs to the RIMBP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=In elongating spermatids, localizes to the manchette.
Protein: PGK_NEIMF
Sequence: MAFLKLTEQNVQGKTVLIRADMNVPFKDGKISDDTRIRASLASIQYCMDNGASVIVMTHLGRPTEGEFHPEDDVAPVAAHLGGLLGKNVKVLNDWRENKPALNAGDVVMLQNVRINKGEKKNDLELGKAYASLCDVFVNDAFGTAHRAQASTEAVAQAAPVACAGVLMAGELDALGKALKQPARPMVAIVAGSKVSTKLTILESLADKVDQLIVGGGIANTFLLAEGKAIGKSLAEHDLVEESKKIMAKMAAKGGSVPLPTDVVVAKAFTADAEAVVKDIADVAEDDMILDIGPKSAAELADLLKAAGTVVWNGPVGVFEFDQFAGGTKALAEAIAQSKAFSIAGGGDTLAAIAKFGVTDQIGYISTGGGAFLEFLEGKELPAVAALEKRGA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUD12_MOUSE
Sequence: MSSVKRNPKKEMISELHSSAAEGNVAKLAGILSHSPSLLNETSENGWTALMYAARNGHPDVVQFLLEKGCDRSLVNKARQTALDIAAFWGYRHIANLLANAKGGKKPWFLTNEVDECENYFSRTLLDRRSDKRNNSDWLQAKESHPTTVYLLFSDLNPLVTLGGNKESSQQPEVRLCQLNYPDVKGYLAQPEKITLVFLGVELEMRKGSPAQAGGVPEEEEDGLVAWFALGIEPGAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGSATKIEEGGYKRVCVRETCPSLQGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVSCQPWPMPSSLMIGCLAVAVSTEIKVDKNEIEDARWFTREQVVDVLTKGKQQAFFVPPSRAIAHQLIKHWVGMNPNL
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:32432673).  The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919).  Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919).  Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (By similarity).  May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity).  Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (PubMed:31875550).
What are the official names of this protein?
NAD-capped RNA hydrolase NUDT12, DeNADding enzyme NUDT12, NADH pyrophosphatase NUDT12, Nucleoside diphosphate-linked moiety X motif 12, Nudix motif 12.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome. Cytoplasmic granule. Note=Localizes to cytoplasmic granules in the presence of BLMH.
Protein: FSIP1_MACFA
Sequence: MDIIKGNLDGISKPASNSRIRPGSRSSNASLEVLSTEPASCKVDTASNLNSGKEDHSESSNTENRRTSNDDKRESCSEKIKLAEEGSDEDLDLVQRQIIPECSDEHKLEELDSQLQDAIQKMKKLDKILAKTQRREKEIKKQGLEMRIKLWEEIKSAKYSEAWQSKEEMENTKKFLSLTAASEETVGPSHENEDSFSSVFHTQIPPEEYEKQMQKLSKDFTCDVERNESLIKAGKKPFSNTEKIELRGKHNQDFIKRNIELAKESRNPVVMIEREKKRLVELLKDLDEKDSGLSSSEGDQSGWVVPVKGYALAVTQHQQLAEIDIKLQELSAASPAISSFSPRLENQNNQEPDLDGEKNMEVTPGEKVLRNTKEQRDLRIRLREIDEKLRMMKENVLQSTSRLSEEQLKCLLDECIVKQKSIIKLSSEGENEDIEDVIPMFPQLSRSIISKLLNESGTKVQKTEAEDADMLESAEREASKGYYLTKALTGHRMSEALVTEVENMKCLQFSKNDIISDTKDYFMSKTLGIGRLKRPSFLDDPLYGITVSLSSEDQHLKLNSPEKTKADEQETKDAAEECKEP
What are the official names of this protein?
Fibrous sheath-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the FSIP1 family.
Protein: RALYL_BOVIN
Sequence: MTGKTQTSNVTNKNDPKSINSRVFIGNLNTAIVKKVDIEAIFSKYGKIVGCSVHKGYAFVQYMSERHARAAVAGENARIIAGQPLDINMAGEPKPYRPKPGNKRPISALYRLESKEPFLSVGGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPRAAVTTTRRGKGVFSMKGGSRSAVSGSSSSGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAEAQKKQLEASLELIQDECVSENADHSAEEPAEGAPDADGEELTDGVEEDFDEDGAHELFLQIK
What are the official names of this protein?
RNA-binding Raly-like protein.
What is the protein family that this protein belongs to?
Belongs to the RRM HNRPC family. RALY subfamily.
Protein: Y1549_PHOLL
Sequence: MSFREVLIVGWQYLRAFVLIYLCLLTGNAISSLLPIIIPGSIIGMLILFVLLAFQLIPAHWAKPGCSLLLKNMTLLFLPIGVGVMNYYDQLSQQIIPIVFSCLISTAIVMIIVAYSSHYVHRERPIVGSTSEINNEQQKQEKQEK
What are the official names of this protein?
UPF0299 membrane protein plu1549.
What is the protein family that this protein belongs to?
Belongs to the UPF0299 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DEOD_SHIB3
Sequence: MATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDKE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: PRIC_ECOLI
Sequence: MKTALLLEKLEGQLATLRQRCAPVSQFATLSARFDRHLFQTRATTLQACLDEAGDNLAALRHAVEQQQLPQVAWLAEHLAAQLEAIAREASAWSLREWDSAPPKIARWQRKRIQHQDFERRLREMVAERRARLARVTDLVEQQTLHREVEAYEARLARCRHALEKIENRLARLTR
What is the function of this protein?
PriA recognizes a specific hairpin sequence on bacteriophage phi X174 ssDNA.  This structure is then recognized and bound by proteins PriB and PriC.  Formation of the primosome proceeds with the subsequent actions of DnaB, DnaC, DnaT and primase.
What are the official names of this protein?
Primosomal replication protein N''.
Protein: RIHB_ECOLI
Sequence: MEKRKIILDCDPGHDDAIAIMMAAKHPAIDLLGITIVAGNQTLDKTLINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGETGLDGPVFEPLTRQAESTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERAGGPAGELFSDIMNFTLKTQFENYGLAGGPVHDATCIGYLINPDGIKTQEMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKTH
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.  Has a clear preference for cytidine over uridine.  Strictly specific for ribonucleosides.  Has a low but significant activity for the purine nucleoside xanthosine.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihB, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihB subfamily.
Protein: PANC_MYCUA
Sequence: MRANAGRAPVFKPGELNVYSAPRDVGEVSRALRHTGRRVMLVPTMGALHEGHLALVRAAKRTPGAVVVVSIFVNPLQFGAGEDLDAYPRTLDQDLAKLRAEGVEIAFTPTAASMYPNGLRTTVQPGPMAAELEGGSRPTHFAGVLTVVLKLLQIVAPDRAFFGEKDYQQLVLIRQMVADLNVNVQVIGVPIVREHDGLAMSSRNRYLDPAQREAAIALSAALTAGAHAATAGVQAALDAARGVLEAVPGIVVDYVELRDGELGPVSPSGSGRLLVAVRFGTTRLLDNVAIEIESIAGTDGQPVGPDGRVQSPWRN
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_STAAM
Sequence: MANHEQIIEAIKEMSVLELNDLVKAIEEEFGVTAAAPVAVAGAAGGADAAAEKTEFDVELTSAGSSKIKVVKAVKEATGLGLKDAKELVDGAPKVIKEALPKEEAEKLKEQLEEVGATVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: GNGF_LACLA
Sequence: MSNPKVVVIGGGTGIPVVLKALRKEKIDLTAIVTVADDGGSSGRIRSAVNIAPPGDLRNVLIAMSDMPKFYADILQYRFDKSDGELAGHPLGNLIIAAVSEMQGSTYRAIQTLAQFFHVEGKIYPSSDAALTLHAVFKDGHEVLGESHIASYKGLIDHVYLTQTASGDSPVASKNVVKSIMEADTIVLGPGSLFTSILPNIVIPEICEALWKTSAKIVYVCNIMTQRGETEHFSDADHVRVLNEHIGTKVIDTVLVNIQEVPEEYMNTNKFDEYLVQVDHDFEALKAEEVNVISNNFLELRDGGAFHNGEAVAKEIVAISQRQEFRH
What is the function of this protein?
Required for morphogenesis under gluconeogenic growth conditions.
What are the official names of this protein?
Putative gluconeogenesis factor.
What is the protein family that this protein belongs to?
Belongs to the gluconeogenesis factor family.
What are the subcellular locations of this protein?
Cytoplasm.