PharMolix/UniProtQA huggingface dataset:
Protein: AIR3_ARATH
Sequence: MKLTHNFSFLLLLLLVHMSSKHILASKDSSSYVVYFGAHSHVGEITEDAMDRVKETHYDFLGSFTGSRERATDAIFYSYTKHINGFAAHLDHDLAYEISKHPEVVSVFPNKALKLHTTRSWDFLGLEHNSYVPSSSIWRKARFGEDTIIANLDTGVWPESKSFRDEGLGPIPSRWKGICQNQKDATFHCNRKLIGARYFNKGYAAAVGHLNSSFDSPRDLDGHGSHTLSTAAGDFVPGVSIFGQGNGTAKGGSPRARVAAYKVCWPPVKGNECYDADVLAAFDAAIHDGADVISVSLGGEPTSFFNDSVAIGSFHAAKKRIVVVCSAGNSGPADSTVSNVAPWQITVGASTMDREFASNLVLGNGKHYKGQSLSSTALPHAKFYPIMASVNAKAKNASALDAQLCKLGSLDPIKTKGKILVCLRGQNGRVEKGRAVALGGGIGMVLENTYVTGNDLLADPHVLPATQLTSKDSFAVSRYISQTKKPIAHITPSRTDLGLKPAPVMASFSSKGPSIVAPQILKPDITAPGVSVIAAYTGAVSPTNEQFDPRRLLFNAISGTSMSCPHISGIAGLLKTRYPSWSPAAIRSAIMTTATIMDDIPGPIQNATNMKATPFSFGAGHVQPNLAVNPGLVYDLGIKDYLNFLCSLGYNASQISVFSGNNFTCSSPKISLVNLNYPSITVPNLTSSKVTVSRTVKNVGRPSMYTVKVNNPQGVYVAVKPTSLNFTKVGEQKTFKVILVKSKGNVAKGYVFGELVWSDKKHRVRSPIVVKL
What is the function of this protein?
Serine protease.  Has a substrate preference for the hydrophobic residues Phe and Ala and the basic residue Asp in the P1 position, and for Asp, Leu or Ala in the P1' position.  May play a role in the degradation of structural proteins in the extracellular matrix of cells located above sites of lateral root formation and thus facilitate lateral root emergence (By similarity).
What are the official names of this protein?
Subtilisin-like protease SBT5.3, Auxin-induced in root cultures protein 3, Subtilase subfamily 5 member 3, AtSBT5.3, Subtilisin-like protease AIR3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall.
Protein: RPOZ_ACTP7
Sequence: MARVTVQEAADKIGNRFDLILTAARRARQLQLHAREPLVPEENDKPTVIALREIEKGLINGQIMDQLENNDAIQQEVAEQEAISFLADVQANA
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: Y1873_ARCFU
Sequence: MLKVKLSLPPDSTFLSQLIYESLLYLSGKKLAKFENGELLIESISKALETFDDERVGEIRIVMSGNDNINAKIFETFGIGGVKSRKTYYDLIALLKEHRDKISTKDESEIHLNIKGKDVFMDINSKSDGIAAPQLLKVDRYTGFSSLDTPYTSQQLTFYLSKEVALLALLGIYSSFVTNVRQQQQSYYYFLFFSPEEVAGLLNSPSLAEKFFLVKESVRESLRELLRRTTFNELLLIETTLNLELQRLMETENLDKISLTLFKIAHEGQTYKIYEQIPITVYRNPAFYETAKKYFRDPLKFSEKLRKAITQGVIPSALAILSTKNKYSEADNILKAIQMLYRFVVLGDLQGWFGFLRELNNAHSKLKNSSDGREKKRAGQYLNIVKEVAW
What are the official names of this protein?
Uncharacterized protein AF_1873.
Protein: KT5BA_XENLA
Sequence: MKWLGESKNMVVNGRRNGNRLSAELRQNQPKLHSPGRENLRTSKNVPDRRSGRFGNVAFEAQSRYVPSSGMSAKELSENDDLATSLVLDPYLGFQTHKMNARFRPIKGRQEELKEVIENFKKKEHLEKTFKNLVAGDWSRHYFLNKTKMQEKHFKEHVFIYLRMFATSSGFEILPCNRYSSERNGAKIVATKEWKRNDKIELLVGCIAELSEAEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRATGAFKSRVGLNEPGPLINSKYGLRETDKRLNRLKKLGDSGKNSDSQSVSSNTDADTSQEKDMSNRKSNGMRKRSKSRTLRRRSMSRIPVSSSSTSSKLPHINNSRVPKRLRKPPKPFHSKLKIRCHRKKVEQKKASKKLEVSNLVLKEPKVVLYKNLAIKKDRESQGAVPVTETTGCLTRHAAREYKLNSLKGAHSHGESSSCTYITRSSLRTRFKSNDMSEAKLQHNSVDGYRSSHGTVLQVDKSEPLCQSTCKNELLQETPRQTIRFHRNNFNTSTRNSRQNRYIKQASKVEDSVSSVYDQSSKDHALPDLGNSHCDLGEGNALIQTSPDYKSFESSADEYPLVTSEITKTKKNNRTAKNKKSRRITRYDAQLILENSTGIPKLTLRRRHDSNSSKTNEKENEGMSSSKISIKLSKDHEKDNGLYVAKLNNGFNSGSGSTSTKLKIQLKRDEENRTAFPNENGMYCNDTLSLLETRMKVDGYDHYEEESVEESSTEEDEEEEDEYDDEFEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
What is the function of this protein?
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity.  In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity).  H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression.  Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions.  KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).  Plays a role in myogenesis by regulating the expression of target genes, such as EID3.  Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).  May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase KMT5B-A, Lysine-specific methyltransferase 5B-A, Suppressor of variegation 4-20 homolog 1-A, Su(var)4-20 homolog 1-A, Suv4-20h1-A, [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B, [histone H4]-lysine20 N-methyltransferase KMT5B.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with pericentric heterochromatin.
Protein: PCBER_PINTA
Sequence: MGSRSRILLIGATGYIGRHVAKASLDLGHPTFLLVRESTASSNSEKAQLLESFKASGANIVHGSIDDHASLVEAVKNVDVVISTVGSLQIESQVNIIKAIKEVGTVKRFFPSEFGNDVDNVHAVEPAKSVFEVKAKVRRAIEAEGIPYTYVSSNCFAGYFLRSLAQAGLTAPPRDKVVILGDGNARVVFVKEEDIGTFTIKAVDDPRTLNKTLYLRLPANTLSLNELVALWEKKIDKTLEKAYVPEEEVLKLIADTPFPANISIAISHSIFVKGDQTNFEIGPAGVEASQLYPDVKYTTVDEYLSNFV
What is the function of this protein?
Oxidoreductase involved in lignan biosynthesis.  Catalyzes the NADPH-dependent reduction of phenylcoumaran benzylic ethers.  Converts dehydrodiconiferyl alcohol (DDC) to isodihydrodehydrodiconiferyl alcohol (IDDDC), and dihydrodehydrodiconiferyl alcohol (DDDC) to tetrahydrodehydrodiconiferyl alcohol (TDDC).
What are the official names of this protein?
Phenylcoumaran benzylic ether reductase PT1, PCBER-Pt1, PtPCBER.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: YNEE_SALTY
Sequence: MIVRPQQHWIRLIFVWHGSVLSKIFSRLLLNFLLSIAVIIMLPWYTMLGIKFTLAPFSILGVAIAIFLGFRNNACYARYVEARHLWGQLMIASRSILREVKTTLPDERGIEDFVRLQIAFAHCLRMTLRRQPQTQVLGNYLDQEALQKVVASHSPANRILLLMGEWLAIRRRSGKLSDILFHSLNNRLNDMSSVLAGCERIANTPVPFAYTLILHRTVYLFCIMLPFALVVDLHYMTPFISVLISYTFIALDALAEELEDPFGTENNDLPLDAICNAIEIDLLQMNDERDIPAKRIPDKRYQLT
What are the official names of this protein?
Voltage-dependent anion channel-forming protein YneE.
What is the protein family that this protein belongs to?
Belongs to the anion channel-forming bestrophin (TC 1.A.46) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ALD1_ORYSJ
Sequence: MPVNMISKLLEKAVLPALDVAPPVKIGGPRRTSVLRNPNMEKLQKGYLFPEISIKREEHLKKYPDAKVISLGIGDTTEPIPSIVTSAMAEYALALSTPEGYQGYGPEQGHKNLRKEIADKVYPDMGIKESEVFISDGAQCDIARLQTLFGPNVTIAVQDPTFPGYVDNGVIMGQTGKADDGGRYAGIEYMRCAPENAFFPDLSRVRRTDVIFFCSPNNPTGHAASREQLRQLVELARRNGSIIVFDSAYSSYISSSSSSSTPRSIYEIPGAREVAIEVSSFSKFAGFTGVRLGWAVVPDELLYSDGVPVARDFDRVVCTCFNGASGIAQAGGVACLSTEEGRGAVARVVGVYRENARVLVETFRSLGKEVHGGGDAPYVWVRFPGRRSWDVFAEILEKTHVITVPGSGFGPGGEGFIRVSAFNSRDKVLEACQRLKSFLA
What is the function of this protein?
Probable aminotransferase that may generate amino-acid-derived defense signals and be involved in resistance to pathogens.
What are the official names of this protein?
Aminotransferase ALD1 homolog.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: HCP2_CLOAB
Sequence: MSMFCYQCQETAGCKGCTVKGVCGKDESVAKAQDLLIYVTKGLAVVSNEGMKVGVKDSKVNKYIVENLFTTITNANFDRDSILDRVRETLRIREDLKAKVVKAGGKVGEVKVSGGFFKKLFGIAKEEMVGPDAATWTADNVIEFDAKAEKVGVLSTENEDIRSLRELITYGLKGLSAYMKHAMNLKYDDETVHEFMAKALAATLDDSLSVDQLVALALEAGKFGVNGMALLDKANTETYGNPEITTVDIGVRKNPGILISGHDLRDLEMLLEQTEGTGVDVYTHGEMLAGQYYPKFKKYKNFAGNYGNAWWKQKEEFEKFNGPIVMTTNCIVIPKASYKNRLFTTGATGMPGCPHIEAKADGTKDFSEVIKMAKKCSAPTEIEKGQIVGGFAHNQVIALADKVVAAVKSGAIKRFFVMAGCDGRANSRNYYTEFAEKLPKDTVILTAGCAKYKYNKLNLGDIGGIPRVLDAGQCNDSYSLVVIALKLQEVFRLKSVNELPISYNIAWYEQKAVIVLLSLLHLGVKNIHLGPTLPAFLSPNVAKVLVDNFGIGGITNVEDDMKMFMQG
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase 2, Hybrid-cluster protein 2, HCP 2, Prismane protein 2.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB1A_PIG
Sequence: MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQGSFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion.  Required to modulate the compacted morphology of the Golgi (By similarity).  Regulates the level of CASR present at the cell membrane.  Plays a role in cell adhesion and cell migration, via its role in protein trafficking.  Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity).  Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity).
What are the official names of this protein?
Ras-related protein Rab-1A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome. Note=Alternates between membrane- associated and cytosolic forms.
Protein: LDH_STRSV
Sequence: MTATKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLFEKAVGDAEDLSHALAFTSPKKIYAATYADCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFNGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAEKIGIDARSVHAYIMGEHGDSEFAVWSHANVAGVKLEQWLQANRDLNEQDLVDLFISVRDAAYSIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVENVFIGQPAIVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPEFQEASKN
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECG_STAAN
Sequence: MHTFLIVLLIIDCIALITVVLLQEGKSSGLSGAISGGAEQLFGKQKQRGVDLFLNRLTIILSILFFVLMICISYLGM
What is the function of this protein?
Involved in protein export.  Participates in an early event of protein translocation (By similarity).
What are the official names of this protein?
Probable protein-export membrane protein SecG.
What is the protein family that this protein belongs to?
Belongs to the SecG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ORN_SHEDO
Sequence: MTADANNLIWIDLEMTGLEPEVDVVIEIATLVTDSELNILAQGPVIAIHQSDETLAKMDDWNQKHHGQSGLIDRVKASQFTEADAIEQTIKFLAQYVPKGASPMCGNSIGQDRRFLNKYMLELEEYFHYRNVDVSTIKELVKRWSPETMKGFTKQGTHQALQDIQESIAELQFYRKEVFKI
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_SHEWM
Sequence: MKTAHEIRPGNVIMLDGSPWVVQKTETTRSGRNAAIVKMKLKNVLLDSSTETTFKGEDKMDDIILERLDCTYSYFADPMYVFMDAEYNQYDVEAGNLGDASAYIVDGMEEVCQVTFYEGKAISVELPTTIVREVTYTEPSARGDTSGKVMKPATVSGGATLSVADFVKTGDMIEIDTRTGEFKKRV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROD_DESPS
Sequence: MHSRKICVSLGQPTMPQALEASLRIFGADVIEVRLDYIDVPEIDPFVESLATDLLFTCRPTWEGGLFAGTEEDRLALLAEAVRAGAAYIDLELRSAEESHQYLRTYLAERETELILSYHDFESTATLAKLTGIIDQMQDAGADIGKLITTANSAADVVRVFQVLEYAAKKGLPLIAFCMGEAGAVSRVASCDLGGYMTYCCADGAEVTAAGQITISEMRGIFARYP
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: V19_SPTNK
Sequence: MHHSFFYDSNTEKISLIAQAAYYDRTLTTPIEIYCNVNLFTFFDSIKHIGLGYNTPTGRDILFDVRFLGNNYYQDPETAPSYPPEFIQMQQEYPTLSNWNAVKTIQLVSNLLPINKESIPSFRNSNVGIINAQGILADFVPLVTNGPEARISIDFVATGPWRLIDMFGSVPIYMVDLYVYWTDQTGGQYLINIPPGRILTCKLVFIKKSLSKYLVSEK
What are the official names of this protein?
Structural protein V19.
What are the subcellular locations of this protein?
Virion.
Protein: RL18A_BOVIN
Sequence: MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L18a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_ECOLI
Sequence: MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.  May play the role of a master protease which is attracted to different substrates by different specificity factors such as ClpA or ClpX.  Participates in the final steps of RseA-sigma-E degradation, liberating sigma-E to induce the extracytoplasmic-stress response.  Degrades antitoxin MazE (PubMed:24375411).
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Caseinolytic protease, Endopeptidase Clp, Heat shock protein F21.5, Protease Ti.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STK4_CHLAE
Sequence: METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.  Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.  Phosphorylates MOBKL1A, MOBKL1B and RASSF2.  Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).  Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.  Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage.  Acts as an inhibitor of PKB/AKT1.  Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
What are the official names of this protein?
Serine/threonine-protein kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Protein: HSP3_BOLBR
Sequence: RRRRRRGKGKGGKKKKGKKRRRRGRKGKGKGKKKGKRKGKRGGKRRRRRRKGKK
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P3.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: HPLN1_HORSE
Sequence: MKSLLLLVLISICGADHRSDNYTLDHDRVIHIQAENGPRLLVEAEQAKVFSHRGGNVTLPCKFLRDPTAFGSGTHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDNDASLVITDLTLDDYGRYKCEVIEGLEDDTAVVALDLQGVVFPYFPRLGRYNLNFHEAQQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGFWDKEKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLKDGAQIAKVGQIFAAWKLLGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN
What is the function of this protein?
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
What are the official names of this protein?
Hyaluronan and proteoglycan link protein 1, Cartilage-linking protein 1, Cartilage-link protein, Proteoglycan link protein.
What is the protein family that this protein belongs to?
Belongs to the HAPLN family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: Y457_PSEU2
Sequence: MLKKSLAALALGTALLSAGQAMAADYVIDKEGQHAFVDFKISHLGYSFIHGTFKDWDGTFSFDAAKPEASKINVELKTASLFTNHAERDKHISSKDFLDVAKYPEAKFVSTAVKSTGEKTADVTGDLTLHGVTKPIVIKATFNGEGKDPWGGYRAGFNGTSTLNLNDFGIKGPGPTSQTLDLDISFEGVQKK
What are the official names of this protein?
UPF0312 protein Psyr_0457.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: A2MGH_ECOLI
Sequence: MDTQRFQSQFHWHLSFKFSGAIAACLSLSLVGTGLANADDSLPSSNYAPPAGGTFFLLADSSFSSSEEAKVRLEAPGRDYRRYQMEEYGGVDVRLYRIPDPMAFLRQQKNLHRIVVQPQYLGDGLNNTLTWLWDNWYGKSRRVMQRTFSSQSRQNVTQALPELQLGNAIIKPSRYVQNNQFSPLKKYPLVKQFRYPLWQAKPFEPQQGVKLEGASSNFISPQPGNIYIPLGQQEPGLYLVEAMVGGYRATTVVFVSDTVALSKVSGKELLVWTAGKKQGEAKPGSEILWTDGLGVMTRGVTDDSGTLQLQHISPERSYILGKDAEGGVFVSENFFYESEIYNTRLYIFTDRPLYRAGDRVDVKVIGREFHDPLHSSPIVSAPAKLSVLDANGSLLQTVNVTLDARNGGQGSFRLPENAVAGGYELRLAYRNQVYSSSFRVANYIKPHFEIGLALAKKEFKTGEAVSGKLQLLYPDGEPVKNARVQLSLRAQQLSMVGNDLRYAGRFPVSLEGSETVSDASGHVALNLPAADKPSRYLLTVSASDGAAYRVTTTKEILIERGLAHYSLSTAAQYSNSGESVVFRYAALESSKQVPVTYEWLRLEDRTSHSGELPSGGKSFTVNFAKPGNYNLTLRDKDGLILAGLSHAVSGKGSTAHTGTVDIVADKTLYQPGETAKMLITFPEPIDEALLTLERDRVEQQSLLSHPANWLTLQRLNDTQYEARVPVSNSFAPNITFSVLYTRNGQYSFQNAGIKVAVPQLDIRVKTDKTHYQPGELVNVELTSSLKGKPVSAQLTVGVVDEMIYALQPEIAPNIGKFFYPLGRNNVRTSSSLSFISYDQALSSEPVAPGATNRSERRVKMLERPRREEVDTAAWMPSLTTDKQGKAYFTFLMPDSLTRWRITARGMNGDGLVGQGRAYLRSEKNLYMKWSMPTVYRVGDKPAAGLFIFSQQDNEPVALVTKFAGAEMRQTLTLHKGANYISLTQNIQQSGLLSAELQQNGQVQDSISTKLSFVDNSWPVEQQKNVMLGGGDNALMLPEQASNIRLQSSETPQEIFRNNLDALVDEPWGGVINTGSRLIPLSLAWRSLADHQSAAANDIRQMIQDNRLRLMQLAGPGARFTWWGEDGNGDAFLTAWAWYADWQASQAIGVTQQPEYWQHMLDSYAEQADNMPLLHRALVLAWAQEMNLPCKTLLKGLDEAIARRGTKTEDFSEEDTRDINDSLILDTPESPLADAVANVLTMTLLKKAQLKSTVMPQVQQYAWDKAANSNQPLAHTVVLLNSGGDATQTAAILSGLTAEQSTIERALAMNWLAKYMATMPPVVLPAPAGAWAKHKLTGGGEDWRWVGQGVPDILSFGDELSPQNVQVR
What are the official names of this protein?
Putative alpha-2-macroglobulin homolog.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
Protein: CRR55_ARATH
Sequence: MKTLVVKCFLLLALVCSCRAADSIWQLCNTNSNISASSQVSKNIDSLLATLVSKTPSKGFKTTTSSSYNNKEKVYGLAQCRGDISNTDCSTCIQDAAKKIREVCQNQSDSRILYDFCFLRYSQENFIGKLDTGAGLIYFNVANVTEIDPKKFDNELGALFDKIRSEAVLPKNKGLGKGKTKLTPFVTLNGLVQCTRDLSELDCAQCFATAVGSFMTTCHNKKGCRVLYSSCYVRYEFYPFYFPLDPAKTGPSVGRISSVHLSP
What are the official names of this protein?
Cysteine-rich repeat secretory protein 55.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: PETG_EMIHU
Sequence: MVEVLLSGIVLGLVPVTITGLFVAAYLQYRRGNQFGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.