PharMolix/UniProtQA huggingface dataset:
Protein: CYSH_BACAH
Sequence: MLTYETWEENDVSFSEEDETKGALSVLSWAYKEYKSEIVYACSFGVEGMVLLHLINQVNPSAKVVFLDTNVHFQETYELIQKVRERFPSLNIIEKQPKLTLDEQDKLHGDKLWESNPNLCCKIRKILPLEESLANEKAWISGLRREQSETRKHTKFINQDHRFQSIKVCPLIHWTWKEVWRYVYKHSLPYNPLHDVGYPSIGCEKCTLPVGEGGDSRDGRWAGKVKTECGLHYQ
What is the function of this protein?
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
What are the official names of this protein?
Adenosine 5'-phosphosulfate reductase, APS reductase, 5'-adenylylsulfate reductase, Thioredoxin-dependent 5'-adenylylsulfate reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1889_STAAM
Sequence: MNDQWYKHLIGARTIKTGIAIFLTAVFCMALDLTPIYAILTAVVTIEPTAKASLIKGYRRLPATVIGAGFAVLFTYLFGDQSPFTYALSATFTILFCTKLKLQVGTNVAVLTSLAMIPGIHDAYIFNFLSRTLTAIIGLVTSGLINFMVFPPKYYGQVEEKLSKTDALMYKLFYNRCQELILSRLQSDKSEKAYKNIFNLNNQVETLISYQRDELSYHKKKECDWKLLNQLTKRAYTNRLFITHLSNIIYLPKNTRVNFSGDEKMALLKISSSIKDIFYDGTFKREDDSVETLRSTIKALEISGENQIKSHILYEVLMIYRLLDSRYA
What are the official names of this protein?
UPF0421 protein SAV1889.
What is the protein family that this protein belongs to?
Belongs to the UPF0421 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUTSL_MIMIV
Sequence: MVSHLIFTDFYSKKFQKMKYSSDSEDNKKETIYTYYFTEQEKYAKIYGSKTLVFIQIGKFYEAYCTRKKGYVNLAELEPLLNIKFIRRDDKPIKDGKPPKPNQFGINCVAISKNLSIMVNHGYTVVLFDQKSDGETIERECVGVYSPGTYLSDIQMQEANYLLSVYISEEKQLTCNKNLMAIGLSLVDISTGTNIIHEFYSNKFDERFGLDELVRMMQTFRPVESVIYYHPVNIDESAIKNVKLYLELDKYHNVHFYIYHNNKGEDALNLLTENSFKINFQNDYLAQIYEMNNQLTLNKKQSPLEILGLERRNYAAVSLMMMLKYIAEHNVLLLKNLSYPEIYLYNKHLILGNNAIEQLNVIDSNNLELYNSKISSVFDVINKTSTPMGKRFLKDNLLNPLSQENKKEIIKRYDYIEALIQGNIFKEIKTELKNIYDIERLHRRMAVGAIVPYEFTRLDNYYKATNRVYSVIKDNDVIKSIIPMNIFKEFVEYQVKYNKEFDTEKMANHANFGEISESFFRKGIHEDLDKIQEKIDYIQSLIKSTNYYFTSIIKDKCKKLGNKEILSMESNDREGYYFTISKSNEKILKQEIDKKKGIIKIDLTIGETLDIKKDDIVFKQLPKGRTKVFMAQLAEYTIKLPSLTEKLTELIKKKFIKSMVTYYSNHKSMLHQITRFVSEIDFLVSGAIVAKEYYYCKPSILSENSIPSYLQAKDLRHVIVERLCDETVYVPNDIELGNVPNIIHTKNKKDSSIEEVSIDETDKFKKVLGKKCNGIVLFSNNWAGKSTCMKSVGIAIILAQIGYYVPATEFNYEPYMALYARITGNDNIFKGLSSFALEMTELDAILMRTEKQGSNTLVIGDEVCKGTEDISGRAIVASALVSLSECDSTFIFSSHLHDIQNIDEVKSLNNLRVYHLRTEYDEENDCIIFDRKLMPGSGPSVYGLLVARYLVKNPKFINRAEIIKKRLTNDINVNLIPKKSNYNKDLLVKQCMICRYIPTTEYHKELESHHIHFQKNCWTDGKIKEKPYLSKNKLYNLVVLCRKCHNKVHQGEIIINGYTDTTIGPLLDYNMDIKKKIINGIKAVDDLEKSFKFSNNKSQIQKTKNTTVKKIQTSKKNNLVCEYA
What is the function of this protein?
May be involved in DNA-mismatch repair.
What are the official names of this protein?
Putative DNA mismatch repair protein mutS homolog L359.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CBID_SALNS
Sequence: MSELSFDAPVWHHGKALRKGYTTGSCATAAAKVAALMVLRQHLIHQVSIVTPSGVTLCLNVESPHIEGQQAIAAIRKDGGDDVDATHGMLIFARVTLNDSGEITLTGGEGIGTVTRKGIGLPLGSAAINRTPRHTIESAVREAIGPARGADVEIFAPEGEARAQKTYNSRLGILGGISIIGTTGIVTPMSEESWKRSLSLELEIKRASGLTRVILVPGNHGERFVREQMGVDTQAVVTMSNFVGYMIEEAVRLGFCQIVLVGHPGKLIKIAAGIFHTHSHIADARMETLVAHLALLGAPLELLTLVSDCDTTEAAMEHIEAYGFGHIYNHLARRICLRVMQMLRFTKTPPVCDAILFSFDNHILGSNRPVDEIAKELQC
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: PURL_THEVO
Sequence: MIYRHIKIRDMNDDDLINMSKRHGLSLSLDEMKAVRDYFIKEGRDPIDAEIHAIAQSWSEHCSYKSSKFYLKKYLTNLKTDYTILAMEDDAGVVEFDKDYAYVLKMESHNHPSAVEPYGGAATGIGGIVRDVVCMGAQPIALVDSLFMGDVASQKYDALLSPRYIFQGVVGGIRDYGNRIGVPNVAGSVYFDQSYNSNPLVNAGCIGIVRKDRIVRSKSYKAGDKLLLVGGKTGRDGIHGVNFASATLTRISKSSRNAIQLGNPIVEHPMMRAVLEANELGIIKAMKDLGGGGLSSAATEMVFAGGFGAEISLDDIKLKDTDMSGWEIWISESQERMLVEVLPEDVEKMKEIAEKWSLDFSILGTVVEGKKITVRYKNKKIIDMDIEFLDKAPVYQRPFERKNIEKKVSIPSEPEDLNDFALNFVSRLNNSARFNVVRQYDHTVRGSTIVGPFSGRPNLETHSDATVIKPLEDSMRGLLITSGSRPNFVSIDPYNGTLETLSEAVRNIVSTGGKPNSVVDALNFGNPERQDIMGQFVESVRAIGDFCRKFSLPVVAGNVSFYNEFRNKDIMPTPTIMMVGIIDDVTKARTTYFKKNKSQIYLVGTPCDNLSGSEYARMNNIFDGFLPAPNLSELQLEIEKIGKFSPYILSAHDVSDGGLFMALAEMSFGSGIGFNIDLGNVSASRSSVKLFSECGNQIVLEIDPIHEEEFTAEFKDLKIVRIGETGGDRIIIDEYGMNLVDLPVQDLRERWEHGLDAYI
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RES_PSEPK
Sequence: MILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQPGWSAQPELTRTLGNRFLDDCSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Expression in E. coli inhibits cell growth.  In vivo it is probably neutralized by cognate antitoxin Xre; this has not been shown upon expression in E. coli (PubMed:30315706).  Probably depletes intracellular NAD(+) (By similarity).
What are the official names of this protein?
Toxin Res.
What is the protein family that this protein belongs to?
Belongs to the MbcT/ParT/Res family.
Protein: AROS_XENTR
Sequence: MSVSLLRKGLDLLREERSGAESSSKKRNSSSKPKPCLSSSKTGMRKQLRRLKQQGLRHDQKATAKGRVIRSAVEEFKKQSAKDHLQQNLQYMLDSSSVTSKEVVDKILKQNRGRKAKDIEIKQHRQIKEKSVFSDADFKRFELEYFGSK
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1.  Direct regulator of SIRT1.
What are the official names of this protein?
Active regulator of SIRT1, 40S ribosomal protein S19-binding protein 1, RPS19-binding protein 1, S19BP.
What is the protein family that this protein belongs to?
Belongs to the AROS family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HDEA_ECO57
Sequence: MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLAVDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGEWDKIKKDM
What is the function of this protein?
Required for optimal acid stress protection.  Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins.
What are the official names of this protein?
Acid stress chaperone HdeA.
What is the protein family that this protein belongs to?
Belongs to the HdeA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DAPE_AGRRK
Sequence: MTATDPVANLQTLIRCASVTPAEGGALTALADMLLPLGFKVERMTASEAGTPDIENLYARLGTEGPHLMFAGHTDVVPVGDAASWSHPPFAADIAGGELFGRGAVDMKGGIACFAAAVARHIEKHGPPAGSISFLITGDEEGPAINGTVKLLQWAAERGEQWDASLVGEPTNPDQLGDMIKIGRRGSISGFITVHGVQGHAAYPHLADNPVRSIVKLTEALLDPPFDAGTDNFQPSNLEVTTIDVGNAATNVIPAKATAAFNIRFNDTWTVETLRAEILARLDAAAADQTLRPGREPTKYDITWSDRPSQVFLTRNNALIASLSSAVENVTGHTPKLSTTGGTSDARFIKDYCPVVEFGLVGQTMHMVDERVAVADLETLTEIYETFIQRWFANAEL
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: SAHH_RHOP2
Sequence: MTAKFTDYIVKDIGLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQTAVLIETLVALGADVRWVSCNIYSTQDHAAAAIAAAGIPVFAIKGESLEDYWDYTARMFDWHGGGTPNMILDDGGDATMYVHLGLRAENGDTAFLDKPGSDEEVIFFALLKKQLKEKPKGYFAEIAKNIRGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVDGIRRGTDVMLSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEVDPICALQAAMEGYQVVTMEDAAPLADIFVTATGNKDIITIEHMRAMKDRAIVCNIGHFDNEIQIAHLKNLKWDNIKPQVDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFTNQTLAQIELFANNKDGKYKKEVYVLPKSLDEKVARLHLAKIGVKLTELRKDQADYIGVKVEGPFKADHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN135_HUMAN
Sequence: MAGLGLGSAVPVWLAEDDLGCIICQGLLDWPATLPCGHSFCRHCLEALWGARDARRWACPTCRQGAAQQPHLRKNTLLQDLADKYRRAAREIQAGSDPAHCPCPGSSSLSSAAARPRRRPELQRVAVEKSITEVAQELTELVEHLVDIVRSLQNQRPLSESGPDNELSILGKAFSSGVDLSMASPKLVTSDTAAGKIRDILHDLEEIQEKLQESVTWKEAPEAQMQGELLEAPSSSSCPLPDQSHPALRRASRFAQWAIHPTFNLKSLSCSLEVSKDSRTVTVSHRPQPYRWSCERFSTSQVLCSQALSSGKHYWEVDTRNCSHWAVGVASWEMSRDQVLGRTMDSCCVEWKGTSQLSAWHMVKETVLGSDRPGVVGIWLNLEEGKLAFYSVDNQEKLLYECTISASSPLYPAFWLYGLHPGNYLIIKQVKV
What is the function of this protein?
E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531).  Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531).  Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531).  This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable).  Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF135, RIG-I E3 ubiquitin ligase, REUL, RING finger protein 135, RING finger protein leading to RIG-I activation, Riplet, RING-type E3 ubiquitin transferase RNF135.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, Stress granule.
Protein: TRPC_CHLP8
Sequence: MTYLTRILETKAEEVAELKKQDPERRYHEACGDLPATRDFRSAITSLDGGINLIAEVKKASPSRGVLVEDFRPLDIAERYAEIGASAFSVLTDRQYFQGSPDYLKAITQKFSIPVLRKEFIIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAELGLHALVETHDERELDTALEQGSTIVGVNNRDLKTFTVDLMTSVRLRQRMPDGIVSVAESGMKHRDDIQMMQEAGFDAVLIGEGLLVSEELRQFSWG
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: YBAK_ECOLI
Sequence: MTPAVKLLEKNKISFQIHTYEHDPAETNFGDEVVKKLGLNPDQVYKTLLVAVNGDMKHLAVAVTPVAGQLDLKKVAKALGAKKVEMADPMVAQRSTGYLVGGISPLGQKKRLPTIIDAPAQEFATIYVSGGKRGLDIELAAGDLAKILDAKFADIARRD
What is the function of this protein?
Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity.  May compensate for the lack of Cys-tRNA(Pro) editing by ProRS.  Is also able to deacylate Cys-tRNA(Cys), and displays weak deacylase activity in vitro against Gly-tRNA(Gly), as well as, at higher concentrations, some other correctly charged tRNAs.  Unlike some of its orthologs it is not able to remove the amino acid moiety from incorrectly charged Ala-tRNA(Pro).
What are the official names of this protein?
Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK.
What is the protein family that this protein belongs to?
Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COL99_CAEBR
Sequence: MCCYLFQQRERERKGTLLTGEAYKLCETITLLDVLQIEQDIPPIGNSDDNSDDVAKSRKVRNSCMCPPGPPGERGPVGPPGLPGLPAPYYRRPRVPLSNVVFVVVIVIVFFKFQNLDESISRKMRAFGMLYSPDGQAIQLRGMPGPPGPAGPKGLRGYPGFPGPIGLDGPRGLPGTPGSKGERGERGPVGPPGFPGPKGDRGVMTGPFGVHGQHPAPSGPIGHHTTMNIGPPGPPGPPGPPGPAGRDGRHGMKGDRGLPGFDGESKIGPKGETGNPGRDGIPGARGPPGERGEKGDTAFLSTYPRGQSVSTVSSSGSQGPPGPPGPPGVCQVSQCIGVQGPPGIPGEPGRTIIGPQGPPGEKGERGERGETGDKGPPGTPGAASLLNGGKALVGPPGPPGRDGRPGEKGEKGEHGLRGDMGLPGPEGTPGKRGRRGRHGISLVAPNGTINEDLKKLLKTELMPLLIEDISELRGKNVIPGPPGPPGPRGHHGPIGPAGERGPQGLPGHSGERGERGDIGPPGLPGQPGAAESSGNQSGPRGPPGLPGPPGEKGDLGPPGLPGQPGALGLPGHPGPMGLRGPHGTEGKQGKQGPEGPKGYPGPMGPQGPPGNDGEPGIDGRPGPAGEKGDQGIPGLDAPCPTGPDGLPLPYCSWKPMDGKNDVWERRKRATLPRSESVPEERTYIKN
What is the function of this protein?
Nematode cuticles are composed largely of collagen-like proteins.  The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).
What are the official names of this protein?
Putative cuticle collagen 99.
What is the protein family that this protein belongs to?
Belongs to the cuticular collagen family.
Protein: Y1980_STAHJ
Sequence: MLHMHIASWALTIILYVIAFLHISKSQGPTPMFKPLQMALRVFMLLTLFSGFWLLIQEFMAASHGGGGNHMLLTLKMLCGIAVVALMEVSIAKRKKHEASHGLFWATIILIIITMSLGIILPWGPISSLFGIS
What are the official names of this protein?
UPF0344 protein SH1980.
What is the protein family that this protein belongs to?
Belongs to the UPF0344 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CRK45_ARATH
Sequence: MAVTSLLDTVFRRRKKKSTEFISFFEFDLDTIKAATNDFSELVGRGGFGFVYKGRLQNGQEIAVKILSTSSIRTERQFHNELIILSKLKHKNLINLLGFCTKRDQHGLVYEFMPNSSLDCFILDPHRAAQLNWEMCRNIIDGIARGLRYLHEESGLWVVHRDIKPGNILLDSDLKPKIVGFELARTMQQGENAAETTEIVGTVGYLDPEYIRSGRVSVKSDVYAFGVTILTIISRRKAWSVDGDSLIKYVRRCWNRGEAIDVIHEVMREEEREYSISEILRYIHIALLCVDENAERRPNIDKVLHWFSCFSTPLPDPTFGNRFLVEEETNWPWSPSLSPGHSSVTSPISSR
What is the function of this protein?
Forms a complex with CRK36 that may negatively control abscisic acid (ABA) and osmotic stress signal transduction (PubMed:22225700).  Involved in plant response to ABA during seed germination, early seedling growth and responses to abiotic stresses by inducing the expression of ABA-responsive genes and stress-inducible genes (PubMed:23583936).  Acts as positive regulator in disease resistance, downstream of NPR1 and WRKY70 (PubMed:24215930).
What are the official names of this protein?
Cysteine-rich receptor-like protein kinase 45, Cysteine-rich RLK45, ABA- and osmotic stress-inducible receptor-like cytosolic kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Note=Interacts with CRK36 at the cell surface.
Protein: NIFW_DECAR
Sequence: MEDTLSLAEAMEDLVSAEDFLDYFAVPYDPAVVHVNRLHILQRFHDYLAKQAPNLPPEESQQRGIYRLWLERAYQDFVTSDSLTEKVFAVFQTVSKPDGGMSSFVSLDKVFRQ
What is the function of this protein?
May protect the nitrogenase Fe-Mo protein from oxidative damage.
What are the official names of this protein?
Nitrogenase-stabilizing/protective protein NifW.
What is the protein family that this protein belongs to?
Belongs to the NifW family.
Protein: NU1M_PAPHA
Sequence: MTTMNLLLLIMSTLAAMAFLTLVERKLLGYMQLRKGPNIVGPYGLLQPFADAMKLFTKEPLKPSTSSTILYITAPALAFSIALLLWTPLPMPNPLINFNLGLLFILATSSLTVYSILWSGWASNSNYALIGALRAVAQMISYEVTLSIILLSILLTSGSFNLNMLITTQEHLWLILPSWPLAMMWFTSTLAETNRTPFDLMEGESELVSGFNIEYSAGPFALFFMAEYMNIIMMNALTTTIFLGTFYPTHSPELFTTSFTIKTLLLTSLFLWIRAAYPRFRYDQLMHLLWKSFLPLTLALLMWSTSMPIAISSIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RSMA_CLOBJ
Sequence: MNTKEIVNKYEFKFNKNLGQNFLIDESVLEDIIEGAEINKEDTVIEIGPGVGTLTKELLERAKEVYSIELDGDLIPILQEELKEYNNFTLIHKDALKIDFNELMENKDSIKLVANLPYYVTTPIISRLLTEKCNFKSLTIMIQKEVAERINAEPNCKEYGSLTVLVQYYCNTKIIRKVSPNSFIPRPKVDSIVIKLDRLSEPRVRVKSQKLFFNVVRSSFNMRRKTLWNSLKSLNINKESMENAFERAGIDSKRRGETLSIEEFGKLSDCIYDIL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_COLOB
Sequence: MSPLTETKAGTGFKAGVKDYRLTYYTPEYETKDTDILAAFRMTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEDNQYIAYVAYPLDLFEEVSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEAIFKSQAETGEIKGHYLNATAGTSEEMMKRAQFARELGVPIIMHDYLTGGFTSNTSLSHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGEREVTLGFVDLLRDDYIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLARQGNDIIREACKWSPELAAACEVWKEIKFEFETIDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RBM8A_SALSA
Sequence: MADVLDLHEAGGEDFAMDEDGDDSIHKLKEKAKRRKGRGFGSEEGARSRVREDYDTVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEFGEIKNLHLNLDRRTGYLKGYALVEYETYKEAQAAMEGLNGQDMMGQPISVDWGFVRGPPKSKRRGGGRRRSRSPDRRRR
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome (By similarity).  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs.  Associates preferentially with mRNAs produced by splicing.  Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs.  Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity).
What are the official names of this protein?
RNA-binding protein 8A, RNA-binding motif protein 8A, Ribonucleoprotein RBM8A.
What is the protein family that this protein belongs to?
Belongs to the RBM8A family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: MURC_ACIB5
Sequence: MSPTTAANQAKKLIKVPEMRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEVKAAIEQRIPIVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGLLNSTGVNAALGESRFIVAEADESDASFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVGRPVITYGFNEDNDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGEFELGEGNVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEKPIVGADSRTLARSIRLRGQVEPILIDPVEGNLQNIMQNVLQPNDLLLTQGAGNVGAISVELAQHHLYVK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMC_SHISS
Sequence: MQCALYDAGRCRSCQWITQPIPEQLSAKTADLKNLLADFPVEEWCAPVSGPEQGFRNKAKMVVSGSVEKPLLGMLHRDGTPEDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGGMMLRFVLRSETKLAQLRKALPWLQEQLPQLKVITVNIQPVHMAIMEGETEIYLTEQQALAERFNDVPLWIRPQSFFQTNPAVASQLYATARDWVRQLPVKHMWDLFCGVGGFGLHCATPDMQLTGIEIASEAIACAKQSAAELGLTRLQFQALDSTQFATAQGDVPELVLVNPPRRGIGKPLCDYLSTMAPRFIIYSSCNAQTMAKDIRELPGYRIERVQLFDMFPHTAHYEVMTLLVKQ
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: CH60_MYCNO
Sequence: PYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGANPLGLKRGIEKAVEKITEGLLATAKEVETKEQIAATAGISAGDQTIGDLIAEAMDKVGNEGVITVEESNTFGL
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, 65 kDa heat shock protein, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.