PharMolix/UniProtQA huggingface dataset:
Protein: DABA_HALMA
Sequence: MSTEPTIHDSIDTAATTVGSLWPIHSFVTANPLAGFEDQPFSEAVTQAADLLGGRGYPSTRTFRAALQRGQIDPEILDAELSEAGYEKEPEILLDRMAEATDAADSDSDTATDHVDQVLTKWLSAFLDEGSAHWSMPNREAGFYAAFRGVAEHDSEIPDAGIIAELPESPIETIETVLASHPENQWVPIFEEQLAALPGWTGLIKQRADDEGAWQSTYPISLVGYLAARLALLDAVGAALAPSNDSIDPDPAAELAGAFLRAWEASYRGDLVETVAAESQSLADSDSSGRPDAQMVFCIDTRSEIIRRHIEATGDYETHGYAGFFGIPMEYQGYDTDVSVDACPPILDPQHHVTDVPIDDDTQESHDRWSGIRDTADEIIETLEANAATAYGFVETAGSGYGLALAARTLVPGRVQDLFDAAGRSVPDDHEFCDPLVHHQHTYTGDLPVGLTTDEKVEYAATAFDLMGWEAFSRLVVFTGHASETTNNPYDSSLDCGACAGNPGGPNARVLATICNDTEVQSALRDRGFEIPEDTVFMAGEHNTTTDEVELYDSEVPESHADDLKQLRANLATARENAAAERAESMGSDASSGVSETQRRAADWAETRPEWGLAGNAGFVIGPRELTSDVDLDGRAFLHSYDWSTDPDGEALEAILTGPMVVTQWINTQYYFSTVDNAVYGSGSKVTHNPVGNVGVYQGNGGDLMTGLPLQSLMAADDDPHHQPLRLSTVIHAPVDRVTDVLADHAELATLLDNNWLSLTVVDPTQDHHAFEYERDLEWSTVSEVSEADPAEPTATAVADD
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NDHI_OXYSB
Sequence: MFPMVTEFMNYGQQTIRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RL3_ALTMD
Sequence: MAIGLVGRKVGMTRIFTEDGTSIPVTVIEATPNRVTQLRTEESDGYRALQVTAGTKKANRINKAEAGHFAKAGVEAGRTLVEFRLEENEGADIEVGSEITVEIFNDTKKIDVTGTSKGKGFQGAIKRWNFSSQRMTHGNSLSHRAPGSIGQNQSPGKVFKGKKMAGQLGNKQVTTQSLEVVRVDVENGLILVKGAVPGATGNDVIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: FADB_SALNS
Sequence: MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGQALEVLEKQHDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTLAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRLPRMLGADSALEIIAAGKDVGAEHALKIGLVDGVVKQETLIEGAIAVLRQAITGDLDWRAKRQPKLEPLKLSKIEAAMSFTIAKGMVAQTAGKHYPAPMTAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDIETPKQAAVLGAGIMGGGIAYQSAWKGVPVIMKDINDKSLNLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPETVLASNTSTIPIGELASALEHPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKEYRDAIDALFDASRFGQKNGLGFWRYKEDSKGKPKKEEDAAVDDLLASVSQPKHDFSDDEIIARMMIPMINEVVRCLEEGIIASPAEADMALVYGLGFPPFHGGAFRWLDTQGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPPVEPARPVGSLKTA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: MENC_BACSU
Sequence: MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVTGWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAKAGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQRIKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKIHDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIRIDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:10194342).  Does not show detectable N-acylamino acid racemase (NAAAR) activity with N-acetyl-S-methionine as substrate (PubMed:10194342).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.
Protein: INP51_YEAST
Sequence: MRLFIGRRSRSIVISSNNYCLSFQRLRSIPGASSQQRQLSKTPSVTIKSYPDTDLSSDSNYLEVKSCIFNGLLGLVCLNGDIYVAVISGVQNVGFPRWKLIDHQVRPSESIYKVLDVDFYSLENDVFDYLLCERSEQNYDKLIHEHPCGPLKKLFSDGTFYYSRDFDISNIVKNHGLSHNLEYTVDNQDLSFIWNANLASEVINWRSKISNEEKQLFANAGFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQDTLELEGISEDGRVSLFVETEIVVTTEKFIFSYTQVNGSIPLFWESVESQLLYGKKIKVTKDSIEAQGAFDRHFDNLTSKYGVVSIVNIIKPKSESQEKLALTYKDCAESKGIKITNIEYSSSVLTKSPHKLLYLLKQDIYEFGAFAYDISRGIYFAKQTGVLRISAFDSIEKPNTVERLVSKEVLELTTNEIDVFELTSPFLDAHDKLWSENYYWLDRTYTKHTKNSGKYTKVYSKLFGSRVRLYDPLHIYISQYLKQLRSKYTFEKDISIFAGTFNISGKIPKDDIKDWIFPKSMSKEDEMADLYVIGLEEVVELTPGHMLATDPYVRQFWEKKILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVSFKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIKDHDAIIWMGDFNYRILMSNEDVRRKIVSKEYASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDPGTKNYDTSEKMRIPAWTDRILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQKKTTLGTQIYEKIMERLEGLDDDEKIAVLSDDAFVIESFEGSDSIAGPTHSPTPIPEPKRGRKLPPPSSDLKKWWIGSGKQVKVVLDVDPAVYMINPKRDPNPFVENEDEPLFIER
What is the function of this protein?
Controls the cellular levels and subcellular distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).  Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P).  Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway.  Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth.
What are the official names of this protein?
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51, Synaptojanin-like protein 1.
What is the protein family that this protein belongs to?
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch.
Protein: GLMU_THEP3
Sequence: MEGLVTLILAAGLGKRMKSKHPKVVHKVCGKPMIEWVVDAVEEIGSKEVIVVVGHKAEEVKEVLKERVKYAYQEVQLGTGHAVMMAEDLLPEEGNVLILTGDTPLITSNTLKELINFHIKEGNSVTILSSVLEDPTGYGRIIRDKSGNVIRIVEDKDATEEEKSIHEINSAMYVMDIAKLKKALRMITNNNAQGEYYLTDAVEIIRDMDGKIGAFTVPSEEITGVNSRVQLFEAEKIMRKRINYRHMENGVTIVDPDTTYIGAEVEIGADTVVLPGCVIEGKTKIGSDCEIGPNCRIVDSEIGDGCSVTYSVILSSKIKNNVKIGPFAHIRPETVIQSNVKIGDFVEIKKSIIDEGSKVPHLTYVGDAEVGKNVNMGCGSITVNYDGKQKHKTVIGDNVFVGCNVNLVAPVKIGNNAYIAAGSTITEDVPEGALAIARSRQTNKEGWVQERIKKGRL
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y949_PSEPK
Sequence: MRLIIVSGRSGSGKSTALDVLEDSGFYCIDNLPAGLLPQLAENALINTELLQPKVAVSIDARNLPSHLMRFPELLEEARARHIQCDVLYLDADEEVLLKRFSETRRRHPLTNANRSLAEAIRVESDLLGPIADLADLKIDTTNLNLYQLRDSIKLRLLNQPEPGTAFLVESFGFKRGMPVDADLVFDVRCLPNPYWKPELREHSGLDQPVIDYLAAQPDVEDMYNDISSYLLKWLPRFAASNRAYVTIAIGCTGGHHRSVYITERLGRQLQQTLKNVQVRHRDL
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein PP_0949.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: FOLD_BORBU
Sequence: MGFKGYILSIVFNGKDFANKYYLMLKEFLKQHNLRDKIALKVVLANDEPASNLYVSIKSRVAKEIGLNVEVIKFSANSVQSDILEVIDRENKNLSTDGIIVQLPLLKGMDLNSILNSIVYSKDVDGLSFVNLGKMILGDKKGFIPCTALAVLKILRDEGIKTLGKTVVVVGRSPLVGRPISILLSSKPYDATVIVCHSKSIYLDVYLRQADIVISAVGKPRLIDKSMLCGKPYVIDIGISEIETDNGKILSGDTDFDNIKECVKFITPVKGGIGPVTVLMLMFNTIKAHLINNRMFDVLNRLEKLLEV
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: COX23_ASPCL
Sequence: MASQSSQADQQQQQQQQSSQSQQPNAWEKAERKFANKNASEYYDPCQDFADRSLKCMKRNAFDKEMCGDYFQAYRDCKKQWLTQKKFS
What is the function of this protein?
Required for the assembly of cytochrome c oxidase.
What are the official names of this protein?
Cytochrome c oxidase-assembly factor cox23, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX23 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: LPTD_NEIMA
Sequence: MARLFSLKPLVLALGFCFGTHCAAADAVAAEETDNPTAGGSVRSVSEPIQPTSLSLGSTCLFCSNESGSPERTEAAVQGSGEASIPEDYTRIVADRMEGQSQVQVRAEGNVVVERNRTTLNADWADYDQSGDTVTAGDRFALQQDGTLIRGETLTYNLEQQTGEAHNVRMETEHGGRRLQSVSRTAEMLGEGHYKLTETQFNTCSAGDAGWYVKAASVEADREKGIGVAKHAAFVFGGVPIFYTPWADFPLDGNRKSGLLVPSLSAGSDGVSLSVPYYFNLAPNLDATFAPGVIGERGAVFDGQVRYLRPDYAGQSDLTWLPHDKKSGRNNRYQAKWQHRHDISDTLQAGVDFNQVSDSGYYRDFYGNKEIAGNVNLNRRVWLDYGGRAAGGSLNAGLSVLKYQTLANQSGYKDKPYALMPRLSADWRKNTGRAQIGVSAQFTRFSHDSRQDGSRLVVYPDIKWDFSNSWGYVRPKLGLHATYYSLNRFGSQEARRVSRTLPIVNIDSGMTFERNTRMFGGGVLQTLEPRLFYNYIPAKSQNDLPNFDSSESSFGYGQLFRENLYYGNDRINTANSLSAAVQSRILDGATGEERFRAGIGQKFYFKNDAVMLDGSVGKKPRSRSDWVAFASSGIGSRFILDSSIHYNQNDKRAENYAVGASYRPAQGKVLNARYKYGRNEKIYLKSDGSYFYDKLSQLDLSAQWPLTRNLSAVVRYNYGFEAKKPIEVLAGAEYKSSCGCWGAGVYAQRYVTGENTYKNAVFFSLQLKDLSSVGRNPADRMDVAVPGYIPAHSLSAGRNKRP
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: VPC27_MYCTO
Sequence: MKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSRTTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
What is the function of this protein?
Probably the toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  Its cognate antitoxin is VapB27 (By similarity).
What are the official names of this protein?
Ribonuclease VapC27, RNase VapC27, Toxin VapC27.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: HIS4_CANGA
Sequence: MTKFVGCIDLHDGQVKQIVGGTLKDNDDSLETNFVSKYPPSYYAQLYLENRIEGCHVIKLGPNNDAAAMEALNAAPGFLQVGGGINDENCLQWLEKASKIIVTSWLFTKEGTFLMDRLQLLSNKCGPDRIVVDLSCRRTPDSKWVVAMNKWQTLTTLELNKETFTELSKYTDEFLIHAADVEGLCKGIETDLVTKLYEWTKDINKEVKIVYAGGAKSISDLELVDKLSNGTVDLTYGSSLDIFGGKLVRFQDCCEWNSKHN
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, 5-proFAR isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_ACIBS
Sequence: MIENPIKRRPTRKIRVGSVYVGGDAPISVQSMTNTETCDVDATVAQIERCVDAGADIMRVSVPSMEAAEAFGAIRKRVSVPLVADIHFDHRIALAVADYGADCLRINPGNIGSDQKVREVVAAARHHGISMRIGVNAGSLEKDLQKKYGEPTGQALLESALRHIDILDRLDFHEFKVSVKASNVFLTMDAYRLLSQQIDNPLHLGVTEAGIYRTGTVKSAIALGGLLMEGIGDTMRISLAAEPEDEIKIGFDILKSLGLRSNGINFIACPSCSRQEFNVIQVMQALEERLEDIRTPMDVSVIGCKVNGPGEAKEADIGVVGAAPRSLVYRNGEKSHLIDTNQLVDEIETMVRQRVQELEEAKSKEIIRSSS
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: NDHK_PHAVU
Sequence: MNSIEFPLLDQTTQNSVISTTLNDFSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAIIDAITKLRKKISREIYEDPISFQRENRCFTINHKFHVGYSTYTGNYGQEFFYQPPSTSEIASDTFF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: LPXD1_ARATH
Sequence: MANSLRTLFSVSTHGVFLNKRSSYRVRKVFVGMPLRICSEIPRFVSVSCIRSDMCGIMMLGKDVHDLLETSSGGNVEKGFLRWRNGGGMYHRSALIDSSALVEFGAVVHQEAILGAEVHIGSNTVIGSSVKIGPSTKIGNCSIGDLCVIHNGVCIGQDGFGFYVDDNGNMVKKPQTLNVKIGNRVEIGANTCIDRGSWRDTVIGDDTKIDNLVQIGHNVIIGKCCLFCGQVGIAGSAEIGDFVALGGRVAVRDHVSIVSKVRLAANSCVTKNITEPGDYGGFPAYKKTEPDSAFASDKHCFILQKILIQVPIHQWRRQIVEAQISSKRKP
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell.  Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.
What are the official names of this protein?
Probable UDP-3-O-acylglucosamine N-acyltransferase 1, mitochondrial, Protein LIPID X D1, AtLpxD1.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: IL1B_CAVPO
Sequence: MAAVPELSSEVTAYHSDENELFFEVDGPNKMQYCFQDRDLCSLDEGIKLQISHQHFNKSFRQTVSLIVAVEKLRKKLAPCTWAFQDDDLRPLLPFIFEEEPIVCDTWDEEYESDTPVPSRNCTLHDIQHKRLVLSDPCELKALHLNGDNLNRQVVFSMSFVQGERSDNKMPVALGLKGKNLYLSCVMKDGKPVLQLESVDGKQYPKKKMEKRFVFNKITSKSTVEFESAQFPNWYISTSQAEHKPVFLGNNNGQDIIDFKLELVSS
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: PPNP_WOLSU
Sequence: MMQSFENVTVVKKANRYFDDKVTSRTVIFPDGSKKTLGIMLPGSYEFGTDKAEIMEILEGELEVFLPQESKWRTLRGGESFDVPAHSRFSLKVNETVDYCCSYVG
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: FTSB_SALCH
Sequence: MGKLTLLLLALLVWLQYSLWFGKNGIHDYSRVNDDVVAQQATNAKLKARNDQLFAEIDDLNGGQEAIEERARNELSMTKPGETFYRLVPDASKRAATAGQTHR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: SYR_XANOR
Sequence: MKALLRALIGQGIEALRANGTLPGDTLPPDFVVERPKTREHGDFATNAAMLLAKAARSNPRALAQALLTALPDSNDVTKVEIAGPGFINFHLAPTAYQREVAHVIKQGHDYGRGLAGNGRSVGVEYVSANPTGPLHVGHGRAAAIGDSLARVLDANGWNVKREFYYNDAGVQIENLALSVQARAQGLTPDSAGWPENGYRGDYIADVANAYLTGDTVDMEGHLVTGTKDPADLESIRRFAVAYLRNEQNHDLAAFRVDFDIYFLESSLYKDGKVEEAVQKLIASGHTYEEGGALWLKSTDFGDDKDRVMRKSDGTYTYFVPDVAYHLTKWQRGYERAITELGADHHGSLTRVRAGLQAMELGIPQGWPEYVLHQMVTVMRDGEEVKLGKRAGGYVTLRDLIEETSADAVRWFLIARKPDSQLTFDIDLARAQSNDNPVFYVQYAHARVCSVLRQAQEKGYKYDQVHGLAELARLDDEHSLAVMLELSRYPEVVEIAGQTLEPYQIAQYLRELAHAFHTWYHNSKVLVDDAAERDAKLTLAVATQQVLANGLELLGVSAPEKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JHY_BOVIN
Sequence: MSHSKFIPTVSIQSPVHHTNIKVQSTEPSFKKEDLHLISKDSLESDSESPTQKIKSQSDLEDQIQDNDMEPDSLEEENLSETEEEASRKAAQRAKKENLHTQDAAAINSRQPTEDKYSHIRYDPNWKSKKEEGKLLPVEALPESVDSSTENLTLNPLYPSKEPSMDLSAGKGEQKSPRSTASLLGSEFVSPNYELSTHRTEPFSVLSDSDPEEKSSNLSRYLKSSSSRSEAFLPGSRGPRRRKSKQYFVEKNKLTLGLPTPRMDSYLQLHNKKRGEGHLEQISYPVRVTDKTSIQNARETGNVAIDPEDKWHQRAQQLKDYQEHWSQYEHEKSSSGPRGQSSETTNGQQPSRKPAKHKIRKQRRHRHGPKSLVTEELVVSQGNQNNTPRHQQNPNKPIDTEVTQETVVIMNATNDDLQYSSVLRSQDPTVTSNQYAPLHQISDKVLYKNPARYYPVTNANRERGHNDQEEKRFSYQQLHIDTLSDMHLNYLHELNKKHPSGSQKGSQSVSNINRQASTEKKKQPKLAYTETKYKNLEILWKFHSSSEEQPAKASPDSRLSQIMEQHQQALLQLTEVQPHEGASPGLTLPPILPRVESESQLSSERSQRNQVKISRSNSESYLFQLEKGKKHRKRSSIKSSKLKGYQNRDVKLGGLGPDLESIRDKMQKLIQQKEYAKQVKEYNMKALSIPSKPQTAITENKSAVPRQKALEYAKTIPKPKPSNLSDQASKEKKTPTHAGKEDTLPEISLLEVLQNRHEREKQAVAAFKVLHIV
What is the function of this protein?
Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces.
What are the official names of this protein?
Jhy protein homolog.
Protein: SYH_MYCVP
Sequence: MTELSSFKAPKGVPDYLPPASAEFVAVRNGLLAAARRAGYGDIELPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVMRAVIEHGLDRGQLPVKLCYSGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAVADAGFRSLGLDGFRLDITSLGDDSCRPQYRELLQEFLFKLDLDEETRRRAEINPLRVLDDKRPHMKEMTADAPVMLDHLSDAAKQHFDTVLAHLDALSVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMHQLGGRDLSGIGFGLGVDRTLLALRAEGKTAGETARVDVYAVPLGGDAKVRLAVLAAQLRAAGVRVDVAYGDRSLKGAMKGADRSGASIALVAGDRDLEAGTVGMKSMATGEQVDVAVEGVVAEVLSRLS
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_METSB
Sequence: MAVPKRKTSPMKRGFRRSADALAAPTYVEDKDSGELRRPHHVDLKTGMYRGRQILTPKNKEA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: CLPP_CITBB
Sequence: MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGGIDDNVANLVIAQLLFLEAEDPDKDIHLYINSPGGVVTAGMAIYDTMRYIKAPVSTICVGQAASMGAFLLSGGEKGKRYSLVNSRIMIHQPLGGFQGQATDIHIHAKEILRMKDQLNALLAEHTGQSVEKVAADTERDYFMSGEEAKNYGIIDAIVTRNVVTGGAN
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR55_DROYA
Sequence: MHTHNNFKTPSDEDELDDLDEDMVVGVIAEIEQEVLNESDSDNDEYDLVDMGAPVPENDGDSSYDGNESISSDDSFDPNAADSDSDDSMLDDAGGASAGGATSAKRRKDDDNPSGSNRQSEATFDLDVDDETDETVRAMIAAIKKPRSAPPEIKLEDFITDICFHPDRDIIALATIIGDVHLYEYDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLKKLYETAHDDAINTLHVLNENLFATGDDAGTVKLWDLRTKNAIFELKELEDQITQLTTNDQNKLLLATSADGYLTTFNIAARKMYVQSEPYEEELSCMGIYRGDSKLVVGTSKGRLYTYNWGQFGYHCDMYPGIKSPISLMIPITDRIACLAGEDGNIRACHIAPYRNLGVVGQHNMPIESLDVNSSGELIASSSHNNDVRFWNVKYFEDFGDIKYNEKHNAYKEQRHNLPSSKCSNASDFFADLTKEDADDDDHDPSAGPSNMA
What are the official names of this protein?
WD repeat-containing protein 55 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
Protein: RBS1B_ARATH
Sequence: MASSMLSSAAVVTSPAQATMVAPFTGLKSSASFPVTRKANNDITSITSNGGRVSCMKVWPPIGKKKFETLSYLPDLTDVELAKEVDYLLRNKWIPCVEFELEHGFVYREHGNTPGYYDGRYWTMWKLPLFGCTDSAQVLKEVEECKKEYPGAFIRIIGFDNTRQVQCISFIAYKPPSFTDA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit 1B, chloroplastic, RuBisCO small subunit 1B.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.