PharMolix/UniProtQA huggingface dataset:
Protein: ACT1_PLABA
Sequence: MGDEEVQALVIDNGSGNVKAGVAGDDAPRSVFPSIVGRPKNPGIMVGMEEKDAFVGDEAQTKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRAAPEEHPVLLTEAPLNPKGNRERMTQIMFESFNVPAMYVAIQAVLSLYSSGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRLDLAGRDLTEYLMKILHERGYGFSTSAEKEIVRDIKEKLCYIALNFDEEMKTSEQSSDIEKSYELPDGNIITVGNERFRCPEALFQPSFLGKEAAGIHTTTFNSIKKCDVDIRKDLYGNIVLSGGTTMYEGIGERLTRDITTLAPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQQMWITKEEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm (PubMed:24743229).  Polymerizes into shorter and less stable actin filaments compared to ACT2/actin-2; this is thought to facilitate gliding motility and host cell invasion (PubMed:24743229).  Has ATPase activity (PubMed:24743229).  ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi (By similarity).  ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin (By similarity).  Plays an essential role during the asexual blood stage (By similarity).  At the segmented schizont stage, required for apicoplast migration and segregation into individual daughter merozoites (By similarity).  Also, required for the separation of daughter merozoites in the final stages of cytokinesis (By similarity).  Essential for merozoite invasion of, but not adhesion to or reorientation towards, host erythrocytes (By similarity).
What are the official names of this protein?
Actin-1, Actin I, PbACT I.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SCN1B_BOVIN
Sequence: MGTLLAFVVGAALVSSAWGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
What is the function of this protein?
Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle.  Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation.  Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
What are the official names of this protein?
Sodium channel subunit beta-1.
What is the protein family that this protein belongs to?
Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection. Cell projection, axon. Note=Detected at nodes of Ranvier on the sciatic nerve.
Protein: TTTP_BPLSK
Sequence: MAMNLLNTASIAKEMQTKVTERMGDWFEAEFKAKANSASRRTRLIRSHGHTYTYARYQNTGQLSSNLKQVKKGDKIVVNAGTRANYTSGYHGMYFLVEKKGMQDVKTTLKKGANYANSMKL
What is the function of this protein?
Plays an essential role in tail assembly by capping the rapidly polymerizing tail once it has reached its requisite length and serving as the interaction surface for the connector and the tail tube proteins.
What are the official names of this protein?
Probable tail terminator protein, Gene product 10, gp10.
What is the protein family that this protein belongs to?
Belongs to the Skunalikevirus tail terminator protein family.
What are the subcellular locations of this protein?
Virion. Note=Located at the interface with the connector and the tail tube.
Protein: CHEB_HALMA
Sequence: MADGVRAVVADDSHFMRSVISDILSDGGIDVVAQARDGEEAVSAVIEHRPDVVTMDVEMPVMNGIEATERIMAESPTPVLMLSAHTDENADVTFEALDKGAVDFFTKPGGEVSMEMSRLKDQLVEMVSSVAAVDVGATGSRSGTGSDSGTAPTTAGGSATDRRGTGGSSGQTTYVANPTLVIGSSTGGPKMVEQVMENLPIEADLRVLIIQHMPEGFTGRFAERINTRSDYEVQEATDGARIGGGEGLVAAGDRHMEVKNYRNGRLRTKLTQDEPVNSVRPAVDVTMQTAAETIDDPLVGLILTGMGEDGADGIRRIKQAGGKTIAQDEATSAVYGMPKRAAETGCVDTVLPIDDIADGVIDTITTEVT
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRIP1_TRIIF
Sequence: MKMIIAVTFLGIVTIAFAEECRLMQPAANFDAATYFSIPHVYVTHSKNEPKTDVCREYDTSKTDGGSTTVITSNYKIKGQAVNNKVTCTSTGLKNGQTGQFSVVCQPPTGAAVTLTTSVLATDNQNYAILQRCPTSGQGNILVLQTAKEGVNPGVKDFFQKKGWNIDSWFSRTNVNCENIQS
What is the function of this protein?
Inhibits platelet aggregation and vasoconstriction through binding to distinct eicosanoids involved in inflammation (acts as a scavenger), and has a role in inhibiting host innate immunity by impairing platelet-assisted formation of neutrophil extracellular traps (NETs) (PubMed:22159626, PubMed:26110417).  Inhibits platelet aggregation by collagen, and low doses of thromboxane A2 mimetic (TXA2 mimetic), and arachidonic acid (AA) without affecting aggregation induced by ADP, convulxin (GP6 agonist), and PMA (PubMed:16759235, PubMed:22159626, PubMed:26110417).  Binds to TXA2, TXB2, prostaglandine H2 mimetic (PGH2 mimetic), PGJ2, and PGF2alpha (PubMed:22159626).  Binding is not observed to leukotrienes, AA, and biogenic amines (PGE1, 5(S)-HETE, 12(S)-HETE, 20-HETE, norepinephrine, epinephrine, serotonine, LTC4 and ADP) (PubMed:22159626).  Induces relaxation of aorta rat previously contracted with TXA2 mimetic (PubMed:22159626).  Moreover, it also impairs platelet-assisted formation of neutrophil extracellular traps (NETs) (PubMed:26110417).  NETs are web-like structures of DNA and proteins that play an important role in killing of pathogens (PubMed:26110417).  In addition, NETs are implicated in thrombus formation (PubMed:26110417).  In vivo, this protein exhibits antithrombotic activity in two distinct mice models that are highly dependent on platelets (PubMed:26110417).  It is noteworthy that it inhibits thrombosis without promoting excessive bleeding (PubMed:26110417).
What are the official names of this protein?
Triplatin, Platelet inhibitor triplatin-1, Tripla-1.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Triabin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPP1_BRADU
Sequence: MRDMLQLVPMVVEQSARGERSFDIYSRLLRERIIFLNGEVNDAMSGLVCAQLLFLEAENPNRPINLYINSYGGVVTSGLAMYDTMQFIKAPVHTLCMGTARSMGSFLLMAGERGHRAALPNASLHVHQPLGGFQGQASDILIHANEMQETKRRITRLYAQHCGRTEAEVERTLDRDHFMTAQQGVEWGLIDRVFAERDAT
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMOK1_MOUSE
Sequence: MEKFHAQYEMLETIGQGGCAKVKLARHRLTGTHVAVKMIPKREYWCKLLMFEAELLMMFNHPNIISLLQVIETKKKVYLIMELCEGKSLYQHIQNAGYLQEDEARPLFKQLLSAMNYCHNQGIVHRDLTPDNIMVEKDGRVKNIDFGLSTHVKPGQKLNLFCGTYPFSAPEVLLSRPYGGPKIDVWTLGVVLYFMVIGKIPFDAASIEKLRKQIVAGKYSAPCRLSVKLQHLINLLMTDNPELRPTVAEVMVHPWITKGSGVFPDPCEEQIPLKPDPAIVKPMGHIGFQAQDIEDSLRQRKFNETMASYCLLKKQILKECDRPIRDQPMNPSVTPFPSLVDTPTFHLGLRRRETEPTGLRLSANRQVSVCGKSTSKKRDRSFIWPGVLSRPINTTPTMDQTHTRTRSVPCIYSNVCTIHPNSIDESTEGHTSASAEDKPVHSRGWPRGIKGWTRKIGNAMRKLCCCIPSKETSHLGQSRVCPKK
What is the function of this protein?
May play a role in sperm motility, especially in the regulation of flagellar function.
What are the official names of this protein?
Sperm motility kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Smok subfamily.
Protein: RL35_SHELP
Sequence: MPKMKTDKGVQKRFKKTANGFKRKQAHLRHILTKKSTKRKRHLRAKCLVAKSDVPAIARQLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: DCTN4_RAT
Sequence: MASLLQSERVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHAQRMNKLIEYYQQLAQKEKVERDRKKLARRRNYMPLAFSQHTIHVVDKYSLGTRLQRPRAGASISTLAGLSLREGEDQKEVKIEPAQAVAEVEPLPEDYYTRPVNLTEVTTLQQRLLQPDLQPVSASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLLECEEGDPDNINSTAKVVVPPKELILAGKDAAAEYDELAEPQDFQDDPDIVAFRKANKVGIFIKVTPQREEGDVTVCFKMKHDFKNLAAPIRPMEESDQGTEVIWLTQHVELSFGPLLP
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
What are the official names of this protein?
Dynactin subunit 4, Dynactin subunit p62.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunit 4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere. Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (By similarity). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (PubMed:10607597). In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity).
Protein: ACP_BORPD
Sequence: MESIEQRVKKIVAEQLGVNEAEIKNESSFLDDLGADSLDMVELVMALEDEFETEIPDEEAEKITTVQQAVDYINSHGKQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y136_VIBCH
Sequence: MDIHVWLAYLLTAVVFSLAPGSGTVNSISNGLSYGTRHSLGAIIGLQIGLACHIVLVGIGIGALVAQSALAFTLIKWIGAAYLVWLGIQKWRDRAPLTATTTSHELSQAALLRKAVLINLTNPKSIVFLVALFPQFIDPTRDHWPQFLVLGITTVTIDAIVMFGYTALAAQLGRYIRSPNIMTRMNKLFGSMFMGCGMLLATAKA
What is the function of this protein?
Involved in positive regulation of motility and negative regulation of biofilm formation.
What are the official names of this protein?
Uncharacterized membrane protein VC_0136.
What is the protein family that this protein belongs to?
Belongs to the Rht family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUR7_HAEIE
Sequence: MTQQSLTLSLKKIYSGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPRKGEILTQISNFWFNKLAHIMPNHFTGDSVYDVLPKEEADLIKDRAVVCKRLTPIKIESIVRGYLTGSGLKDYKQTGTICGLKLPENLVEASKLPEAIFTPSSKEEVGNHDINISYAECEKLIGSDLAAQVKEKAIALYTEASEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQAGTNPPSFDKQFVRDWLENSGWNKQAPAPKVPKNIIQKTVDKYQEALDLLTK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RNPA_STRTD
Sequence: MKKSYRVKKEKDFKALFDAGHSVANRKFVVYCLDRNLPHFRVGLSVSKRLGNAVTRNRVKRRLRHALMDMSSQLENQDFVVIARKGVEDLSYQDIYSNLVHVLKIAKLYKD
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: SYL_NATTJ
Sequence: MKEYQPQKIESKWQKRWQDEISYETEVDHNKDKYYVLEMFPYPSGKLHMGHMRVYSIGDVLARFQRMRGYNVLHPMGWDAFGLPAENAAIENQDLPSRWTYANIDNMKDQLQALGTSYDWKREVSTCSPDYYKWTQWMFLQLYKNGLAYKKKAPVNWCPECETVLANEQVENGACWRCDSMVEQKQLSQWFFKITEYADRLDQDLELLEEWPDRVKTMQKNWIGKSQGTEIDFPVKGSREKIRAFTTRPDTIFGATYMVLAPEHPMTEQLVQGTDQEKEVMDFIKGVHEMGKEAREAEDLEKEGVFTGRWAINPLNGEEIPILVGNYVLMEYGTGAIMAVPAHDQRDFQFAHKYNLPIKEVVTPPEGEGKTESETHDELKKAYTDHGILINSPGYNGMTSEQAIEQITRDIENKGIGAGVTTYRLRDWLVSRQRYWGAPIPVLYCDQCGILPVPEDELPVQLPEDVDFSQGSRNVLAARQDFVETSCPQCGGSAQRETDTMDTFVCSSWYFLRYTTPWDNEVPFRQEDVNYWMPVDQYIGGIEHAVLHLLYARFFTKVMYDQGYTNFKEPFSRLLAQGMVNKDGAKMSKSKGNVVSPDEILRTYGADTGRLFILFAAPPEKDLDWNDEGVEGCYRFLQRLYRLVNDNQNLVDLQLDDTKFTKEDKEYHRLIHKTIKKVTDDISERHNFNTAISAIMELTNASSKYKEQKEVNESLLRTGLETIVMLLAPFTPHIAEELWETLGYQDSVHKLNWPSYDEKAMVAEEAEMVVQVNGKVRDHLTVPADSSEETIKEKALEREKVQKYISGAEIKKVIVIPQKLVNIVCK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_SALPA
Sequence: MSEMTPREIVSELNKHIIGQDNAKRSVAIALRNRWRRMQLDEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNNWGQAEQQQEPSAARQTFRKKLREGQLDDKEIEINLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKPRKLKIKDAMKLLVEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGETSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQVAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASVTVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNETTENIGARRLHTVLERLMEEISYNASDLHGQNITIDAEYVSKHLDALVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Heat shock protein HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_ARAHI
Sequence: MVREKVKVSTRTLQWRCVESRRDSKRLYYGRFILSPLMKGQADTIGIAMRRALLGEIEGTCITRAKSENIPHDYSNIVGIQESVHEILMNLNEIVLRSNLYGARNAIICVQGPGYITARDIILPPSVEIIDNTQHIATLTESIDLCIGLKIERNRGYSLKILNTFEDRSYPIDAVFMPVQNANHSIHSYGNGNGKQEILFLEIWTNGSLTPKEALHEASRNLINLFIPFLHVEEETFYLENNQHHVTLPLFPFHNRLVNLRKKKKELAFQYIFIDQLELPPRIYNCLKKSNIHTLLDLLNNSQEDLIKIEHFHIEDVKKILDILEKKIEKAFQKKID
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SPB4_ENCCU
Sequence: MGCKGIEDVAMNGRLKKEIEENGFGKMTEVQLKCIPEVLKGKDVVVQSPTGTGKTMAFLAPILSCIYDGKGRGRPGVTAVVITPTRELALQIREVAGLFDVKCECFIGGMSIEEDYKRMKEEFSIAVGTPGRLLEIVGKETKKFSSLSHLVLDEADKLLGFGFEEKLMQLLAKLPRNRVTGLFSATRNDSVDKLSRVFLRNPVSINVGNNEMPVALEYIVVSPMEKLLVLMDIVTGRRCIVFFATCSEVDFFSGLVSRAGFGNICKIHGKISQDERNRVYEEFFQRDGLLFCTDVAARGIDFRGVDLVVHFDVPKEYSSIVHRSGRTARNGSKGESVLFVMPNERAYVEFLKLKGIPAVESSYRMKSSLSYQDIKSMISPELLGLSVKAFVSYIRSYKEHFVSYILDYKGLDFDSLAELFFLERIPGMAELRNVKFEKFTKPARDGKKRALPKKKYRKKRAIK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.  Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA.  Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5. 8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
What are the official names of this protein?
ATP-dependent rRNA helicase SPB4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ISPT2_COREF
Sequence: MSELVPPNIPAEFLPRHIALVMDGNGRWATEKGMKRTEGHRRGEAVLLDVVDACLALGVPYLSAYAFSTENWRRSTEEVRFLMGFNRDVLRRQRDGLHEKGVRVRWVGRRPRLWRSVIRELEAAEELTKDNTNMTLAMCVNYGGRAEIIDAAREIARQAAAGQLRPEQINEKTFPDFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTPQDLFDAVEEYARRDRRFGTA
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase 2.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: RECR_HALHL
Sequence: MSVYSPRLRELVEGLRRLPGVGAKTAQRMALHLLQRDRDGARQLADALQRAVDGVGHCPECGLLTEEERCGLCASPQRRRTLLCVVESSADVFALEQATDFQGLYFVLGGALSPLDGIGPEELGLDRLQQRLEAGEVEEIILATNPTIEGEATAHYVQSLAAERGVRTTRIAHGVPMGGALEQVDQGTLSHAFMGRRDYEG
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: DTD_PROMH
Sequence: MIALIQRVTQAKVDIAGVTVGAINHGLLVLLGVEKDDNQQKAKRLCEKVCGYRIFSDENDKMNLNVQQAGGSLLVVSQFTLAAETQKGMRPGFSNGAPPEMAENLYHYFVEQCKQQGLETQTGQFAADMQVTLTNDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_PSEPF
Sequence: MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLADNEVLVKKLDMIPVECVVRNYAAGSLVKRLGVEEGMKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNEVLSKLFDDAGLLLVDFKLEFGVFSDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVANRLGVPL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RS3_FRATF
Sequence: MGQKVNPNGIRLGYIRDWRSTWYADSSRYATKLNEDIKVREFLHKKLAAAAVSKIQIERPAQNAKITIHTARPGIVIGKKGEDVEKLRAEVHKLMGIPVQINIEEVRKPEIDAKLVAESVAQQLEKRVMFRRAMKKAMQAAMKSGAKGIKIMVSGRLGGAEIARSEWARDGRVPLQTFRADVDYATAEALTTYGVIGVKVWIYKGEILPGQIAEKKNNKKGAK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: Y358_MYCMM
Sequence: MPRTADDSWDIATSVGATAVMVALARAAETASETPLIRDQFAEPLVSTPELAAVREQVAAWWAQTDDDDDPDFTVDSQQMTDYLAVRTHFFDSYFIDAVAAGIRQVVILAAGLDSRAYRLDWPGGTTVYEIDLPKVLDYKEHTLARHGAAPVAALRAVPVDLRHDWPQALRDAGFQTSLPTAWLAEGLLPFLPAAAQHALFTAIDANSATGSRVAVEMFGVDEDARRAAEERAQRWARQRAKRQARGQDTSFDPFDLWFDDEGQPDPADWFAAHGWTTDSVQAGAEALRLGRTAHSQEGPFVNRFVTAGKP
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MMAR_0358.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: ATG4_SCLS1
Sequence: MTTVDIGRYKRLVQYFWDPEPTNNIASKSPIWCLGEEYLVSDKSSPSAVTESPPKEGGYLLAQSLSTTETTTPPDSTVGSLESSSEYDNCDTASTDGGWPTAFLDDFEAKIWLTYRSNFPAIAKSQDPKALSAMSLSVRLRSQLVDQGGFTSDTGWGCMIRSGQSLLANALLTLRMGREWRRGSSSNEERKILSLFADDPRAPYSIHKFVEHGASACGKHPGEWFGPSAAARCIQALTNSQVESELRVYITGDGSDVYEDTFMSIAKPNSTKFTPTLILVGTRLGLDKITPVYWEALKSSLQMPQSVGIAGGRPSSSHYFIGVQESDFFYLDPHQTRPALPFNDNVEDYTPEDIDSCHTRRLRRLHIKEMDPSMLIAFLIRDENDWKDWRRAVREVQGKGVIHVADRDPALHGLGAERDGAIDEVETFDDDDDDTVLNG
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease atg4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.