PharMolix/UniProtQA huggingface dataset:
Protein: PSAB_CHLVU
Sequence: MATKFPKFSQALAQDPTTRRLWFGIATAHDFESHDGMTEERLYQKIFASHFGQLAIIFLWTSGNLFHVAWQGNFEQWVQDPLHIRPIAHAIWDPHFGQAAVEAFTRGGASGPVNISTSGVYQWWYTIGIRTNQELYVGSIFLLVLAGLFLFAGWLHLQPSFQPALSWFKNAESRLNHHLAGLFGVSSLAWTGHLVHVAIPESRGQHVGWDNFLTVLPHPAGLTPFFTGNWAAYAENPDSLSQLFGTGEGSGTAILTFLGGFHPQTQSLWLTDMAHHHLAIAVVFILAGHMYRTIFGIGHSMREILEAQTPPSGRLGAGHKGLYDTVNNSLHFQLGLALASVGTICSLVAQHMYSLPPYAFLAQDFTTQASLYTHHQYIAGFIMCGAFAHGAIFFVRDYDPEANRGNVLARVLDHKEAIISHLSWVSLFLGFHTLGLYVHNDVVQAFGTPEKQILIEPVFAQWIQAAHGKTVYGFDFLLSSATSAPSLAGQSLWLPGWLQGINSDTNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYFHWKHLGIWQGNVNQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLIYATGFMFLISWRGYWQELIETLAWAHERTPLANLVRWRDKPVALSIVQARLVGLTHFSVGYVLTYAAFLIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PLSX_BRUO2
Sequence: MIKISIDAMGGDFGPEVVIPGAAKAFERHPDIRFIFFGLPAQVEPVLARYPKLKEASEFRASEVAIGMDDKPSQALRAGRGKSSMWQAIEAVKTGDADACVSAGNTGALMAMSKFCLRMMSDVERPAIAGIWPTLRGESIVLDIGATIGADARQLVDYAVMGAGMARALFEVRKPTVGLLNVGTEEVKGLDEIKEAGQILCDTPLDGLEYSGFVEGNDIGKGTVDVVVTEGFTGNIALKTAEGTARQMAELLRQAMSRTLLAKIGHVFAKGAFDRLREKMDPNKVNGGVFLGLSGIVIKSHGGANAEGFCSAVEVGYDMVRNRLLEKIEADLAHFHHSHSHVSSKA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ACP1_HORVU
Sequence: MAHCLAAVSSFSPSAVRRRLSSQVANVVSSRSSVSFHSRQMSFVSISSRPSSLRFKICCAAMGEAQAKKETVDKVCMIVKKQLAVPDGTPVTAESKFSELGADSLDTVEIVMGLEEEFNITVDETSAQDIATVQDAANLIEKLVTEKTA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein 1, chloroplastic, ACP I, Acyl carrier protein I.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NFI_XYLFT
Sequence: MKISSIDSIFAAWDGSITEARRLQSDMAERIVLKDEPNLLSEPTLLAGFDVGFEDEGRTTRAAAVLMNAGDLRLLETHVVRVPTSMPYVPGLLSFRELPALLQALTQLSRIPALVFVDGHGIAHPRRLGIAAHFGLVTNLPCIGVAKKRLVGDFVEPGTAFGEHTPILLHGTQVGWALRSKMHCKPLIISPGHKVSLHSALTWTQRCLTGYRLPEPTRQADRLASRRGQKIVSDLPSLL
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEY1_PARBA
Sequence: MVANGHFFAGVGDVLDGKNYEHGVQVVDEEKEFNPNLSNYLTYENVTPAGFNYHLISVFGSQSTGKSTLLNSLFGTHFSVMSETERRQTTKGIWLSKNKGLKSDKGQDNQTKMADNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLELFLKDKRSNPRSLLFFVIRDFLGTTPLQNLQNTLLQDLNRIWNSLSKPAGLENSSITDYFDFAFAGLPHKNFQPEKFVDEVQKLSTRFCDGHRDPNKTDAKGTGSIEGGIFLPEYHRRIPADGFAVYAEGIWDQIVNNKDLDLPTQQELLAQFRCDEISREVLVAFDEAISPFEAKQAEAVQAGNPQVLGGLGSAMRNARMKSVKNFDTEASRYHKRVYQMKKSELQDKIDFRLKALFLGQLSAAHRSGIQEFTESVTAAVKAGQKRGASYDFAEIVKKERKLAIEKFEQEARATVVEDTQWSNYQQELSLYQKDLEIIGGQLRRDEMRRLATRVERWVRSRLGESIDLEFNAIGSGRSGSGAPEFGDKPSEKSLWDRVWTLFIDIVLDAERRFTERASSFDASIDEVDVGLWRLRRKSWGVLRAKIDEEMMEGNILLKLRENFEDKFRYDDAGVPRIWRPNDDIESIYTRARESTLTLIPLLSRFRLSETNAPPPLDKWIGHTPSSATPADEEDLTPIGGVDEDEGKSLEEEMTMIGEAKKQDLTVRFKKTADGVYVEAKRSAIGGITQVPLYFYGLLLALGWNEIVAVLRNPAYFLLLFVCAVTAYVTYQLNLWGPIIKMTEAASQQALMEGKRRLREFLEASDTGLQTMAMSEGRNAEGYDMSNMKNRKSAGGYQNNRSHIDDADDDDDF
What is the function of this protein?
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein SEY1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: HXA7_PANTR
Sequence: MSSSYYVNALFSKYTAGASLFQNAEPTSCSFAPNSQRSGYGAGAGAFASTVPGLYNVNSPLYXSPFASGYGLGADAYGNLPCASYDQNIPGLCSDLAKGACDKADEGALHGAAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKDDGPTAAAAPEGAVPSAAATAAADKADEEDDDEEEEDEEE
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A7.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDH2_AQUAE
Sequence: MKGKLINSFLMKKPKISVIGAGKVGENVAYLLTILGLGDVYLFARYKKGLEPAKAKALDLKQMAVLMDIDINVKGISYDKEGFEELKGSDIVVITAGIPRREGMSREDLLYENLKILKKFTDAIKEYAKDSIIIVVSNPVDTLTYATIKLTGFEPRRVIGMAGVLDSARFKNFVKEKIGISNADIRTLVLGTHGDLMVPVTSHSFIGDKPIEEVFSASEIDELIEKTRKGGAQIVSLMGTSAYYAPAASVVIMVESIINDRKRVMPCSVYVEGEAAKHYEIEGVCIGLPVVLGKKGVEDFELVNLSGYEKRELLRSAKTLKEMVSLADKLLNEL
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily.
Protein: COMI_DICDI
Sequence: MELLRQGEHLHSTSRSTLESKCRKYKLIMQNDGNLVLYIGSLKSQSDEYCLWSSASCGKGHGPYRLSMQEDGNLVIYDSRNSAIWASGTMGHGVRGHYSMKLRSSGQIVVYDKYKQILYSSKPCTRDHLLSLPCAKPSGHPQSAYPPQQPGYGYPAQPGYPPQPGYPPQHGYPPQHGYPQQPGYY
What is the function of this protein?
May have a role in cell motility.  It has high affinity for both G-actin and F-actin.  Binds to vesicle membranes via mannose residues and, by way of its interaction with actin, links these membranes to the cytoskeleton.
What are the official names of this protein?
Comitin, 24 kDa actin-binding protein, CABP1-related protein p24.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Primarily on Golgi and vesicle membranes.
Protein: STHA_SALPA
Sequence: MPHSWDYDAVVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNAHFIDEHTLALECHDGTVETLTAEKFVIACGSRPYHPNDVDFSHPRIYDSDSILSLHHEPRHVIIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALENIGLETDSRGQLKVNSMYQTALPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_HELPJ
Sequence: MVKESDILVVGGGHAGIEASLIAAKMGVRVHLITMLIDTIGLASCNPAIGGLGKGHLTKEVDVLGGAMGIITDHSGLQYRVLNASKGPAVRGTRAQIDMDTYRIFARNLVLNTPNLSVSQEMTESLILENDEVVGVTTNINNTYRAKKVIITTGTFLKGVVHIGEHQNQNGRFGENASNSLALNLRELGFKVERLKTGTCPRVAGNSIDFEGLEEHFGDANPPYFSYKTKDFNPTQLSCFITYTNPITHQIIRDNFHRAPLFSGQIEGIGPRYCPSIEDKINRFSEKERHQLFLEPQTIHKSEYYINGLSTSLPLDVQEKVIHSIKGLENALITRYGYAIEYDFIQPTELTHALETKKIKGLYLAGQINGTTGYEEAAAQGLMAGINAVLALKNQAPFILKRNEAYIGVLIDDLVTKGTNEPYRMFTSRAEYRLLLREDNTLFRLGEHAYRLGLMEQDFYKELEKDKQAIQENLKRLKECVLTPSKEVLKRLNELGENPINDKMDGVSLLARDSFNLEKMRSFFSFLVPLNERVLEQIKIECKYNIYIEKQHENIAKMDSMLKVSIPKHFVFKGIPGLSLEAVEKLEKFRPKSLFEASEISGITPANLDVLHLYIHLRKNS
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_TRIL1
Sequence: MSRKCEICGKGPSTGNNVSHANNKTRTTWYPNLQKVKAKAANGSVSTIKVCTRCIRSGSVTKAL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: N2F1B_DANRE
Sequence: MAMVVSAWRDPQEELAAVDDQSAAGREHLQHRHSPKSAEEKAQIAAQNQQHVECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPVDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPNQPNPSHYALTNGDHLNGQCYLSGYISLLLRAEPYPASRYGNQCMQSGNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQSSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRFFQEQVEKLKALQVDSAEYSCAKAIVLFTSDACGLSDIPHIEGLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPALRMVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMPIQ
What is the function of this protein?
Putative transcription factor that is required in photoreceptor cells precursors during eye development.
What are the official names of this protein?
Nuclear receptor subfamily 2 group F member 1-B, COUP transcription factor 1-B, COUP-TFalpha-B.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AMP1_COCNU
Sequence: SVAGRAQGM
What is the function of this protein?
Has antimicrobial activity against Gram-positive bacteria B. subtilis (MIC=76 ug/ml) and S. aureus (MIC=80 ug/ml), and against Gram-negative bacteria E. coli (MIC=82 ug/ml) and P. aeruginosa (MIC=79 ug/ml).
What are the official names of this protein?
Antimicrobial peptide 1, Cn-AMP1.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: POA1_YEAS7
Sequence: MSNITYVKGNILKPKSYARILIHSCNCNGSWGGGIAYQLALRYPKAEKDYVEVCEKYGSNLLGKCILLPSYENSDLLICCLFTSSFGGSSHGEKQSILNYTKLALDKLKTFREAKDKTRTSEDSIGDYLNGHIKYPIGEYKLEMPQINSGIFGVPWKETERVLEEFSGDMSFTVYQL
What is the function of this protein?
Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.  Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety.  Inactive towards proteins bearing poly-ADP-ribose (By similarity).
What are the official names of this protein?
ADP-ribose 1''-phosphate phosphatase, [Protein ADP-ribosylglutamate] hydrolase.
What is the protein family that this protein belongs to?
Belongs to the POA1 family.
Protein: RL4_NITSB
Sequence: MSKAVVLNENFEKASEVALPEHFQGINPHNLYLYAKAYAANLRANNAHTKSRGEVSGGGRKPWQQKGRGGARAGSIRSPLFVGGGVAFGPKNTKNYTQKVNKKQKRKALEFALNEKGEQGALFIVDSIAVESGKTKDAAAIVNKIGARDVLVVKENIDEKTFLAFRNLPNAYLIEPNELNAYLAAAFRAVVIERPVWEKIVKEG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ARGE_ECOLI
Sequence: MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRNKFNMLASIGQGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVTKLKKPLYILATADEETSMAGARYFAETTALRPDCAIIGEPTSLQPVRAHKGHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYEAFTVPYPTLNLGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVSERWPGRLTVDELHPPIPGYECPPNHQLVEVVEKLLGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVIHHFCWH
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT22_LYCMC
Sequence: MKSFLLIALVLFFLFVSYASAKNKCQLPSDVGKGKASFTRYYYNEEGGKCETFIYGGVGGNSNNFLTKEDCCRECAQGSC
What is the function of this protein?
Dual-function toxin that completely inhibits trypsin activity at a molar ratio of 1:1 (dissociation constant of 160 nM) and that inhibits mKv1. 3/KCNA3 potassium channel currents (1 uM inhibits 50% of currents).  It is thermostable.
What are the official names of this protein?
Kunitz-type serine protease inhibitor LmKTT-1b, Delta-KTx 2.2, SdPI.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Scorpion delta-Ktx subfamily. Delta-Ktx 2 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DC4C_ACIAD
Sequence: MNDEQRYKQGLEVRTEVLGEKHVNRSLENLNDFNQDFQNFISRFAWGEVWSRPGLPRHTRSLVTIAVLLALGREDELRMHLRACFNNGVTKDELKELILHCSLYAGLPASNAAMHMAEEVFKDLGIAPEKVNKD
What are the official names of this protein?
4-carboxymuconolactone decarboxylase, CMD.
Protein: ATPB_SARHE
Sequence: MRINPTTSGPGVSTLEGKNLGRIAQIIGPVLDVAFPPGKMPNIYNAFVVKGRDTAGQQINVTCEVQQLLGNNRVRTVAMSATDGLMRGMEVIDTGAPLSVPVGGATLGRIFNVLGEPVDNLGPVDTRTTSPIHRSAPAFIQLDTRLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNLAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTSQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAINLEMRSNLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RISB_ACIB5
Sequence: MAIRRIEGLLHLASEGRYAILVGRFNSFVVEHLLEGAIDTLKRHGVNEDNITVIHAPGAWELPIVAKKLATSNQFDAIIALGAVIRGSTPHFDFVAGECAKGLGVVALESSLPVINGVLTTDSIEQAIERSGTKAGNKGSEAALTAIEMVNLLKAI
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: APOE_NEOSC
Sequence: MKVLWAALVVALLAGCWADVEPESPLQGKPEPELEPELEPKRELEQEVEAEAGWQAGQPWELALARFWDYLRWVQTLSDQVQEDMLSNQVTQELTTLMEETMKEIKAYRAELEEQLGPMASETQARVAKELQAAQARLRSDMEDVRTRLTQYRGEVQAMLGQSTEELRARFASHMRKLRKRVLRDAEDLQKRLAVYRAGVREGAERSVSSIRERLWPLLEQARTRHANLATQPLRERVDALGQQLRGRLEEVGSRARSHLDEVREQMEEVQAKMEEQANQMRQQVEAFQARLKSWFEPLVEDMQRQWAGLVEKVQVAVGTSPTTPPLETK
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: CYSI_XYLFT
Sequence: MSSSSIEDIKGKSHRLRGSLLESLANPTTGALGESDQTLIKYHGSYQQDDRDLREERRRQKLEPAYQFMIRTRTPGGVITPQQWLQLDAIATRYANHSLRVTTRQAFQFHGVIKRELKTTMQAINAALIDTLAACGDVNRNVQVAANPLLSRAHADLYTDAAHLSEHLLPNTRAYYEIWLDEKKVAGAGEEEEPIYGPHYLPRKFKIGFAAPPINDVDVFANDLGFIAVIVDNTLLGYNVTIGGGMGTTHGDPDTWPRVGNIIGFITRADLITISTAIVTTQRDFGNRTLRKRARFKYTIDDRGLDCIVGEIQQRAGITLQPARPFVFEHNGDRYGWIEGEDGHWHLTLSLPAGRIADTEGSTLLSGFREIAQLGIGEFRMTPNQNVVIAGISPGQRAAIDALVTQYGLDTGNRAPTALGRHAMACVALPTCGLAMAEAERYLPDFNAKLQPILEKYGLAEAPILLRISGCPNGCSRPYLAEIALVGKAPGRYNLMLGGDQRGQRLNTLYRENITETEILAALEPLLGRYQQKRLPSEGFGDFLHRTGIIALPPYPTHRHVISSTLQA
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: PRAL1_MOUSE
Sequence: MSCKTPPTLQELAENSLLKNQDLAISALDDIPSLFFPSLFKKACRNRYVGIIKAMVQAWPFPCLPLGAMISRKTAYRRILEIILYGLDALLSQKVPHSRCKLQVLDLRVMPLKLWNRLPVFGTAGCSENPAVVGHSGTEVKQPVKVLVDLVLKESPLDSTESFLVQWVDNRNGLVSLCCCKLQIWAMSMYYHRKLLEILDLDSVQELRMYCISNPVCLLNFAPYLGRMRNLRCLILSHLWQTFSMTPVEKQQVITQFTSQFLKLKCLQILHLDTVFFLEGHLDELFWWLKTPLETLSVIDCNLSKSDWFHISEFQCTSQLKHLNLKWVKLTHLSPEPLRVLLLKSASTLTSLDLEGCQMMDSQLSAILPALRCCTQLTKFNFHGNYISMPILRELAYNVVKQKSQQSKIRFIPSCSHHSGLEFEAISQPHIVFVDVDRTTGEQEQVLFYAICSGEYVL
What is the function of this protein?
May play a role in acrosome development and also in sperm maturation and motility.
What are the official names of this protein?
Preferentially expressed antigen in melanoma-like protein 1, Prame-like 1.
What is the protein family that this protein belongs to?
Belongs to the PRAME family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=Located in the cytoplasm of spermatocytes and in the acrosomal vesicle region of round, elongating and elongated spermatids. Detected in the main piece of the flagellum in testicular spermatozoa. Detected also in the connecting piece, middle piece and cytoplasmic droplets of epididymal spermatozoa.
Protein: SMRCD_RAT
Sequence: MNLFNLDRFRFEKRSKIEEAPEAAPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDVTEKTEDSSVPEPPDNESKASLSCFQNQRTIQEYIDLSSDSEDVSPNCSSTVQEKKFSKDTVIIVSEPSEDEESHDLPSATRRNDISELEDLSELEDLKDAKLQTLKELFPQRSDSDLLKLIDSTSTMDGAIAAALLKFGDAGGGPRKRKLSSSSEAYEEDEANDDQSLKKPRGDRREESNESAEASSNWEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESLKVFAEDQDVQCASQSEVTNGKEVARNQNYSKNAAKIKMKQKISMKPQNGFNKKRKKNVFNPKKAVEDSEYDSGSDAGSSLDEDYSSCEEVMEDGYKGKILHFLQDASIGELTLIPKCSQKKAQKIIELRPFNNWETLFTKMSKINGLSEDLIWNCKTVIQERDVVIRLMNKCEDISNKLTKQVTMLTGNGGGWNIEQPSLLNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCPTLNVLCYYGSQEERKQIRFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKPADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKLLPPKKDQIELCAMSEKQEQLYSGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQYYTAEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYQHINSYQLDMDLILDSGKFRTLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLEQDMTTVDEADEGSMPADIATLLKTSMGL
What is the function of this protein?
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization.  Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs.  Required for the restoration of heterochromatin organization after replication.  Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity).
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage (By similarity).