Protein: OPDA_PENO1
Sequence: MSPSIPEPIAIVGSSCRFPGSSSSPSKLWDLLREPRDVRRNLSQNLNLQRFYHPSGENHGSTDVKGLGYLLAEDSRLFDPAVFGISPYEAETIDPQQRILLEIVYESMENAGYTLAQMRGSQTSVHVGVMTDDYHDIQLRDVESLPQYTSTGTARSMMANRISYVFDLHGPSVTIDTACSSSLVALHQAVQSLQLGEATCAVVGGVNLIFDPAMYVAESNLHMLSPDSQSRMWDKTANGYARGEGAAAVLLKPLSQALRDNDHIEGLIRGSGVNSDGQSPGITMPTATAQAALIRATYKRAGLDPIKDRCQYFECHGTGTAAGDPVEAQAISEALFEEATFTNEATDTPPLYVGSIKTVTGHLEGCAGLAGLLKALVSIKNRIIPPNMLFNELNPKIEPYYGRMQITTVPIPWPNVGTGAPLRVSINSFGFGGTNSHVILESYESSGQRNLELASKKNALLGPIVLSAHSGASLLGNAKNMLQYLKDNPSVNLSDLSYVLQTRRTAHRARAFFSSSSHQGLINKLQDFVGDNEKISKKSTIGIRHKPVNSSETPGILGVFTGQGAQWPRMGRMLLDHCPLFRDVLERCDATLQALPDHPEWLLVDELCKHAEVSRVGEAAISQPLCTAIQLGLLEVLFSSGIHFDAVVGHSSGEIAAVYACGIISLSAAMQIAFYRGRYASLAQGANGEVGAMMAVGISHREAQKFCQKSEYQGHISVAASNGVQSVTLSGDSEFIQQAKEHFESENVFARLLKVDTAYHSQHMKRCAGPYLQSLEACNIQVRQPREGCFWNSSVRGDTELLRGDLRSLKGPYWVQNMVQTVLFSQAVRSSIWHGGPYDVVIEVGPHPALKGPTEQTLQSAFGATPTYTGVLKRDSNDVEALFDAIGVVWAHLGPQFVNFEGLWRTLVPDSTQLSPRLLKDLPKYSWDHERVYWRESRISARFRRGNDVFHELLGRRTHDDTDRELRWRNILKLSELPWVQGHTIMGEALLPGASYVALAFQAGHAIAAGRRVQLMEVQDVEIRRPIVVPDSREGQDTIFTVHLLDARDPNMIEGHFSYCYCSDTSTGAMVRTCEGRLIIHLGETTGDELPPYTPPPPNLLSVDTDEGYEVLAQAGLLYSGIFRRLQDVERRLDFAEAKAQWATEELRGEYVVHPALLDVSFQSIFHARADPSTGKLPVSVLPVHIKRVVVNPKATLGAQMGTIRTMTQSFVTARDGLSLSGDIHVFDAMTGEAALQVEALSVKPMAPPTAEQDTRLFFDTVFMADPSLNLLEPQRNPVDDTRDMALVSDIDRVVLYYVQRVLEQLDPEEVAGFSWYFKRMLDAYEYWVQLVRADRHPVAPSSWLADEFEVIDEIYTRWPGQIELEIARAIGENIVDVMHGKMQMLEVLMENDRLGRMYYEGCGFTIVNAGLRNVMEQISNKYPQAKYLEIGAGTGSASHAILSSIGTTFDNYTYTDISTGFFENAAKRFAQFSHKMLFKTLDVEKDVVAQGYDMHSYDVVVASNVLHATGNLQLTLENVRSLLKPGGFLLLIEITGIEIMRVGYIMGGLPGWWLGAKEGRRFHPGLTTEDWDRTLQDTGYSGVDLAFHDLPDSDRHCMSLLVSQAVDETVLQLREPLGYIEDVPKTDNLLLIGGRTLPISKLTSTVQRLAGSSWRSRVVVARDIEAVDFSLLSSSVDVVCLQELDAPLFSNFITTKRLEALQAIILHSRNVLWVTKSRRAENPYQNMFLGMARAIWKEMAHVTIQSLDVETITNPNNVARTILETFLRMKILSGVDNQSTLLWTREQELIIEGGETLIARLRPNQELNDRYNARYRTVTKSVNGSHAAIRLIQQGDKMAFTETDDHHPADTIEHVTVKTSFSLTVPGDSSQGSTYLVVGREIDVGTPLLAVSHIDASVLRVPQTDTIPIDEASCNELFLERFLNNIFSDTLLNLIAAGGSVTLYQPRNGLAAVIAATAEDRGIEVFFVCSTSGDVAVPENWIWMHPHSSPRIIRSLLPRNDSIFVNCSGLSNYLTSAIHSVLPSHLPVLELESWVFQTGLSVLRGCGSLAAGYDSLLSRLPRLNAALPLSGDLPLFNMDQIAGAKASTQEITHITSWEKAKDFLTLVVQPPDPTTMFDARKTYLMVGMAGGLGLSICEWALRHGAKQMVITSRNPEIHSQWLADARHKGTIVHVKSMDVTDRASVDTTVRWIQDTLPPIAGVCNAAMVLTDRMFANMDADAINRTLNPKVNGSKYLDEVFANTPLDFFILLSSCGAIMGSKGQSNYHAANMYMSALATQRRERGFAASIIHIGFVTDVGYTTRNKGTLKDVWAQFEFRFLSEMDVHHAFAEAIVSGRPNSHRSCEVGVGINPLTEPFTADRKPAWASDPRFSHYLPSTNLQNEVVARSRQEDLKERLMDVSTEDEAVEITQKAFSSKLETMMQLPVGSLSVQASLIELGIDSLVAVDIRNWFLRELGADIPVLKILGGDSVAQICTNAAKQLLAQKGGQEPSEQEEVEPESTTLHVSQGSLHTPSEGLEFTETSSVGGTENTPLTSASSSPSVTDTVEKRDKGDISVDEGPNEQFDPDDRDYNPDIIETERLSSGQSRIYILSRFLNNPTDYNLVFQFEIDGCLDMELLRDAFTVTTQHHESLRTCYFVRQEDNQPMQGVLASPVVRFQHVPDATADEIAAEVALGKSRVWDLERGETMAMTVFSLSPQSHTMVFSYHHIIMDSTGWRVFFQDLALAYHMEPLQHASKTYVEYTRKQIAQQQTGHFQSQLQYWKQEYSSFPPVLPLLPMSRVKTRPNAQSSGITYSRLEIGYEVAQAMKASCQKLRITAFHFHLAVFQVMLSQLAGIDDICIGVADANRLDGEFAETVGFFMNMLPVRFHVSPNAKFSQIAQGTARKVLGAVQNSAVPFDMILDDLHVARSSSHTPLFQAAINYQLRVAKKLPFAGSSLTLFDAQDAKNPYDLSLGIIEYHSEGFILDMSCQESLYDAAATRTILETYVQILEGVVSNTYMTVAKIPIHAPIAVIDAVRLGQGPQVDFSWPATLSQQFQAIHETNREDLAICDGDQSLTYDQLTDRVNSIASALKTVGHTTSLRVAVLCRPSVDFTASMLAILHIGALYIPLDISLPPARHAAIIDSARPSVVICHDATIELASQLGAGSEGNRMPIIRVDDVEVAKERVPCNARPEAPAVLLYTSGSVGKPKGVVLTQANFVNHIALKIHELNLRLGCEKILQQSSLGFDMSIIQIFCALCTGGTLFIVPYESRRDALHITQLMSKHRITITIATPSEYLTWLHYGWDSLVQCFDWRWACMGGEVVQPPLMREFQRLGLASLSCLNCYGPTEITAAATFHRISLKEDVLKLESTVGKAIPNYTLRIVDFSGRTQPVGFRGEICIGGAGLALGYWESLEETARAFFVDGSSTRWYRTGDQGRLTADGSLVFLGRLEGSTQVKVRGLRIELEEVEKALLEVGASLFSTVVVTVRDDALMAYATPLVNQGDDIEPAIITELLAGLPLPQYMCPSQVIIVDDLPCNSNGKIDRNALATLPFSAPSQGLFNPQTAPKLSLRQSELRILWEKVLPPTSHPLMAESDFFLEGGNSLRLLKLQHAIKESMGTSITTRELYEASTLQKMTMLVDLERDRQTVKSKLIDWEAETAIPESLITIAQDAIGAVKRSPVDDDEVVEVLMTGATGFLGGSILKELLQNVHIRRVHCVAILPDEQGHLPSDSKVVHYTGSLSSPTLGLSPSECLALQESIDVVIHAGANGHCLNNYTSVREANVHPTQFLASLCVPHSIPLLYISSPRVPLLTGNTAPLPGPVPTQPPTTGAEGYTASKWASEQFLQRMSNHASMRIEIHRPCVVIGDQAPASDALNAILRYSLKMKCLPKFSRVEGFFDFKKVEEVAQDLVSSTVALGLGRGRSQTGREAKVHFQHHSSGKKVAFSAMAKHMKEMYGEEFSEMEILDWLERALKEGMDPLISSYLESLVENGDTLQFPYLGEVHSS
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of oxopyrrolidines, polyketide-amino acid hybrid compounds with feature structures of tetramic acid (PubMed:36005526).  The polyketide chain is first assembled by the highly reducing PKS module of opdA using acetyl-CoA as the starter unit and five malonyl-CoA as the extender units (PubMed:36005526).  OpdC acts as trans-acting enoyl reductase and reduces the terminal alkenyl to alkane (PubMed:36005526).  The 17R in oxopyrrolidine A and 15R, 17S in oxopyrrolidine B are generated by non-stereospecific catalysis of the ketoreductase (KR) domain and enoyl reductases (PubMed:36005526).  Then the polyketides with specific configurations are transferred to the NRPS module of opdA and linked to L-tyrosine to form an amide bond (PubMed:36005526).  Finally, the oxopyrrolidines are offloaded through a Dieckmann cyclization catalyzed by the terminal D domain to give a tetramic acid moiety (PubMed:36005526).
What are the official names of this protein?
Hybrid PKS-NRPs synthetase opdA, PKS-NRPS iliA, Oxopyrrolidines biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.