PharMolix/UniProtQA huggingface dataset:
Protein: VEMP_CVMA5
Sequence: MFNLFLTDTVWYVGQIIFIFAVCLMVTIIVVAFLASIKLCIQLCGLCNTLVLSPSIYLYDRSKQLYKYYNEEMRLPLLEVDDI
What is the function of this protein?
Plays a central role in virus morphogenesis and assembly.  Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport.  Also plays a role in the induction of apoptosis.
What are the official names of this protein?
Envelope small membrane protein, E protein, sM protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses E protein family.
What are the subcellular locations of this protein?
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Protein: PETD_GUITH
Sequence: MSVLKKPDLTDPKLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTLACVIGLSVLAPSPIGEKADPFATPLEILPEWYFFPTFNLLRVIPNKLLGVLSMAAVPVGLITVPFIESVNKFQNPFRRPVAMTVFVFSVVFAIWLGIGATMPINKALTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GLPF6_LACPL
Sequence: MRKYLAEFLGTFMLVFLGTATVVIAKGDVLAIGLAFGLAITVSAYAFGGISGGHFNPAVTTAMLINRRIDAADAIGYIIAQIIGAIVASAAVKSFVSALGLSATLLGQTDFPKIGSGMAFFVEALVTFLFLMVILNVTSNDHGNADFAGLTIGVTLAFLIIVALNLTGGSLNPARSIGPAIFAGGSALSHLWVYILAPEVGAILAAFCARVMGSED
What is the function of this protein?
Probable transporter that facilitates the transmembrane diffusion of an unknown substrate.  Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid.
What are the official names of this protein?
Glycerol uptake facilitator protein-like 6.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLIF_BUCBP
Sequence: MNMGRTSNLNVKNRDLKRNFFSNLSLNVRVLLLVFLITLIVFYIFFFKPLNYSILYNNLSNDDEKSIVSRLISLKIPFKFNQNHSELLIPSNALKKVYLDLAEQGLPKEKKVGFELLDTEKFGLSQFNEEVNYERALEGELARSIQKLENIKTARVHIVLSKSSVFIREKKIPSASVILEIKPGRYLNYNQINSILHIVAQGVSNLQIENITIVDQFGNLLSSMNDLYNDSYSNNQLKYSNEIETGYKNKIESVLVPLVGVNNIHAQVTAQISFDKQENSEERFTPNYSNEKQSVRSVQNKKNIEFSEKYSDNSFSSNQGVLSNKKLNDLSNSSLLFNHNNIPNFSEQVSSTKNSKRNLSDESVIPQSSTNQNYIVNYELDHVISHNKFNVGNVKRLSVAVVINYVKDKHGKFVSLSTDKLNSIKKLVCESVGFSRKRGDSVSVVNFKFSTPEVYFQSPPSNYNKYISFNNLFEFFLICLGVIILCLLIIKLNFLKILFKNKKRIDISNNYAVKDNLTSQNKGVEDDKELKKKLSSVLESDPKEIAMVIRKWISG
What is the function of this protein?
The M ring may be actively involved in energy transduction.
What are the official names of this protein?
Flagellar M-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FliF family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Protein: RL3_THISH
Sequence: MAIGLVGRKLGMTRVFTEDGASLPVTVIEVDPNRVTQVKTEERDGYRALQVTTGARKASRVTKPRAGHFAKAGVEAGRGLWEFRLDGDQGAEIETGAELKVDIFEAGQIVDVTGISKGKGFQGVIKRHNFSMQDATHGNSLSHRAPGSIGQNQTPGRVFKGKKMAGHMGNERCTVQNLEVVRVDVERNLLLIKGAVPGSTGGNVLVRPGVKAKG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ZNTB_YERPE
Sequence: MDVVEGKALQVSDAVYAYQLDGKGGMTAISVDAVASATQPCWLHLDYTYPESAEWLQNTPLLPEVVRDGLAGESMRPKITRLGDGTMITLRGINFNNDARPDQLVTIRVYMTDKLIVSTRHRKVYSIDNVLNDLQSGTGPTGSGHWLVDIADGLTDHTSEFIEDLHDKIIDLEDDLMEQKVPPRGQMALLRKQLIVLRRYMAPQRDVFSRLASERLPWMNDDDRRRMQEISERLGRGLEDLDGSIARTAVLSDEISSLMADAMNRRTYTMSLLAMVFLPTTFLTGLFGVNLGGIPGNTDAFGFTIFCMMLVVLVLSVAWWLKRSKWL
What is the function of this protein?
Zinc transporter.  Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.
What are the official names of this protein?
Zinc transport protein ZntB.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSTN1_HUMAN
Sequence: MSQAGAQEAPIKKKRPPVKDEDLKGARGNLTKNQEIKSKTYQVMRECEQAGSAAPSVFSRTRTGTETVFEKPKAGPTKSVFG
What is the function of this protein?
May be involved in the development and regeneration of the musculoskeletal system.
What are the official names of this protein?
Musculoskeletal embryonic nuclear protein 1.
What is the protein family that this protein belongs to?
Belongs to the MUSTANG family.
Protein: RS17_THEAQ
Sequence: MPKKVLTGVVVSDKMQKTVTVLVERQFPHPLYGKVIKRSKKYLAHDPEERYKVGDVVEIIEARPISKRKRFRVLRLVEEGRLDLVEKYLVRRQNYASLSKRGGKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: SYCT_YERE8
Sequence: MQTTFTELMQQLFLKLGLNHQVNENDVYTFEVDGHIQVLIACYHQQWVQLFSELGADLPTNDNLFGEHWPAHVQGRLDGKPILWSQQSLVGLDIDEMQAWLERFIDDIEQRKESQNTKFQPNSTSPILFI
What is the function of this protein?
Functions as a specific chaperone for YopT.
What are the official names of this protein?
Chaperone protein SycT.
Protein: PPIA_DICDI
Sequence: MTTVKPTSPENPRVFFDITIGGVEAGKVVMELYANTVPKTAENFRALCTGEKGIGKSGKPLSYKGSSFHRVITNFMCQGGDFTMGNGTGGESIYGNKFADENFKLKHFGQGTLSMANAGANTNGSQFFICVAPTDWLDGKHVVFGFVTEGMDVVKKMEAAGSQSGKTTKPVVIANCGQL
What is the function of this protein?
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RS15_LEGPC
Sequence: MSLNSAEKAEIINEYKRGDKDTGSPEVQVSLITSRIKYLTDHFKENKKDFHSRRGLQELVNKRRKLLKYLKRNDQDRYQTLIQNLGLRDSY
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: DAPH_BACVZ
Sequence: MKMMDANEIISFIQNSTKSTPVKVYVKGDLEGISFGDSAKTFLNGQSGVVFGEWAEIKSVIEENKDKIEDYVIENDRRNSAIPMLDLKDVKARIEPGAIIRDQVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEPPSAKPVVVEDDVVIGANAVVLEGVTIGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKDIDEKTKGKTEIKQELRQL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: MLTC_ENT38
Sequence: MKKLLALALVAPLLVSCSSKKGDSYNEAWVKDTNGFDILMGQFAHNIENIWGFNEVLIAGPKDYVKYTDAYQTRSHINFDDGTITIETIAGTEPAAHLRQAIVKTLLMGDDPGSIDLYSDADDVTISKEPYLYGQVVDQTGQPIRWEGRATTFADYLLQTRLKSRTNGLKIIYSVTINLVPNHLDKRAHKYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHSAGKDVFRSQGKSGTPSRSYLFDPQSNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSSDKVQAANIINSMAPGDVYQTLTTRHPSGESRRYLYKVNSAQKNYRRR
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: Y1723_ROSS1
Sequence: MAERRRRLGDWGEAVAVAYLAQHGYQVVAQKWRCAAGEIDIVAQRDGVLAFVEVRTRRGVDPGMAAGSITGAKRARLMMLACLFLAAHDLPADTPWRIDVVAIAVASQGRVAIDHILAAVEET
What are the official names of this protein?
UPF0102 protein RoseRS_1723.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: MURB_MYCLE
Sequence: MKRSAVGSFFAGAHVAEAVSLAPLTTLRVGPVAQRVITCASTEQVVDVIRQLDAPAGGRGAGPLLIFAGGSNLVIADTLADLTAVRLANAGITIDGNLVRAEAGAVWDDVVVRAIEHGLGGLECLSGIPGSAGATPVQNVGAYGAEVSDTITRVRLLERSSGSVRWVSACELRFGYRTSVFKQADPSGSQPPAVVLEVEFKLDASGQSAPLHYGELVATLDATSGQRANPHAVREAVLALRVRKGMVLDAADHDTWSVGSFFTNPVVAPDVYRQLAKMVDGPVPHYPAQDGVKLAAGWLVERAGFGKGYPDGAAPCRLSTKHVLALTNRGAATAEDVVTLARTVRNGVLEVFGITLEPEPALVGCVL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_PSEA7
Sequence: MAERKASVARDTLETQIKVSIDLDGTGKARFDTGVPFLDHMMDQIARHGLIDLDIECKGDLHIDDHHTVEDIGITLGQAFAKAIGDKKGIRRYGHAYVPLDEALSRVVIDFSGRPGLQMHVPFTRASVGGFDVDLFMEFFQGFVNHAQVTLHIDNLRGHNTHHQIETVFKAFGRALRMAIELDERMAGQMPSTKGCL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_CHLTE
Sequence: MDLSSLRPAKGAVKARKRVGRGPGSGNGTTAGKGNKGQQSRSGYQRPVIEGGQMPIYRRLPKFGFTPPNQKAVACVNVAQIQMWIEKGLVGEEISVLDLKHLCNASNQEYFKVLGNGELTSTVTITAHFFSKSAEEKIAKAGGKIVKAYRTLEEAAKVNGLPFEEALLTPKAKVVKVKKEKKSVKS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: SYGB_HAES1
Sequence: MTTQNFLAEIGTEELPPKALKKLATAFAENVEQELNQAGLAFEKVEWFAAPRRLAVKVLGLAEAQPSKQVEKRGPAVSAAFDAEGKPTKAAEGWARGCGITVEQAERLSTDKGEWLVHRAVIEGQLTKNLLVGIIDKALAGLPIPKTMRWGDKTEQFVRPVHTVTLLFGADLIEGEILGVASGRTVRGHRFLGEREFSLDHADQYPQLLKERGSVVADFNERKALILATSREKATALGGVADIEEELLEEVTSLVEYPNVLTAKFEERFLAVPAEALVYTMKGDQKYFPIYDKDGKLLPHFIFVSNINPDDPSKIIEGNEKVVRPRLTDAEFFFKTDLKQKLEDRLPRLETVLFQQQLGTLRDKTARIEALAGEIAAQIGADQTKAKRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEDEDVAVALNEQYMPRFAGDTLPNSLVACSVALADKIDTLTGIFGIGQSPKGSADPFALRRAALGCLRIIVEKNLPLDLADIVAKATALFGDKLTNKNVVDEVVDFMLGRFRAWYESEGIAVDVIQSVLARRPTKPADFDARVRAVSHFRTLDSAEALAAANKRVSNILAKADIAIGEIDLGVCVESAEKTLAEAVLALKGEVQPLIAQGDYTAVLDKLANLRQPIDAFFDGVMVNVEEQTLRQNRLAILSTLQNLFLQVADISVLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_PSYIN
Sequence: MLTSSGYIQHHLTNAQMCTVDGSIAFNYACADAGFWTWHIDSLLFSVGLGVLFLFVFYKVGQKATTGVPGKLQCAVEMLMEFVSNAVKDSFHGRSPVIAPLALTIFVWILLMNTMDLIPVDFIPEAAKQILGVPYLKVVPTTDMNITFGLSLSVFALIVFYSIKIKGITGFVKELTLQPFNHWAFIPVNFILETIALIAKPISLSLRLFGNLYAGELIFILIALMPWWSQAALSVPWAIFHILVIVLQAFIFMMLTIVYLSMAHEDH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNMG_CLOBM
Sequence: MKYLAGDFDVVVIGAGHAGCEAALASARMGCKTLICTMNLDSIALMACNPNIGGTAKGHLVREIDALGGEMGINIDHTFIQSRMLNTSKGPAVHSLRAQADKKRYSERMKHLLEKEENVVLRQLEVIEIDVEDNEVKGVLTKNGAYFTTKAIILCTGTYLKGKIIIGDIIYSSGPSGLYPANDLSQSLLDLGINLRRFKTGTPARINKRSVDFSKMVEQPGDEKIVPFSFIHDKLDKDQISCYLTYTSEETHKIIHENIHRSPLYNGSIEGIGPRYCPSIEDKIVRFPDKDKHQIFIEPEGENTEELYVGGMSSSLPEDVQIKMYRSVPGLENAEILRTAYAIEYDCIDPQQLDLTLEFKNINGLYGAGQFNGSSGYEEAAAQGLVAGINAVLKIKGKDPLILKRSDAYIGVLIDDLVTKGTNEPYRMMTSRAEYRLLLRQDNADLRLTEMGYRIGLVKEDRYNKYLNRKKNVENEIERIKKVQITGKKEINEFLLEKGSTELKKPISLYELIKRPELDYFKVEPLDDKRPNLSDDEKEEINIIAKYEGYINKQLEQVEQFKKYENRLIPKSINYSDIKGLRIEAIQKLEKIKPINIGQASRISGVSPADISVLLIYMERKNREN
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPH1_MOUSE
Sequence: MIEDNKENKENKDHSSERGRVTLIFSLENEVGGLIKVLKIFQENHVSLLHIESRKSKQRNSEFEIFVDCDISREQLNDIFPLLKSHATVLSVDSPDQLTAKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKIACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGLKYNPYTQSVQVLRDTKSITSAMNELRYDLDVISDALARVTRWPSV
What is the function of this protein?
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
What are the official names of this protein?
Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Protein: UDB31_CANLF
Sequence: MSMKWISVLLGLQLSCYFSSGSCGKVLVWPTEYSHWINVKTILDELVQRGHEVTVLTSSASILVDPNKLSAIKFEIYSAHLSRGDFEAFFIKLLNILIYDMPKDSFWTYFSLMQEFFWEFYECAQKLCKDVVLNKKLMTKLQESKFDLVLADTIIPCGELLAELLKIPLVYSLRFSPGYAFEKHSGGLPLPPSYVPVILSELTDQMTFMERVKNMLYVLYFDFWFQTINEKSWDQFYSEVLGRPTTLYELMRKADIWLIRTYWDFEYPHPLLPHFDFVGGLHCKPAKSLPTEMEEFVQSSGENGIVVFSLGSMVNNMTEERANVIASALAQIPQKVLWRFDGKKPDTLGPNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQADNIVHMKAKGAAIRLDFSTMSSADLLNALRMVINDPSYKENAMKLSGIHHDQPIKPLDRAVFWIEYVMRHQGAKHLRPASHDLTWFQYHSLDVIGFLLACVATAIFVTTQCCLFCCRKVAKTGKKIKKE
What is the function of this protein?
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.  This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs.
What are the official names of this protein?
UDP-glucuronosyltransferase 2B31, UDPGT 2B31.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: PCKA_SALPA
Sequence: MRVNNLTPQDLKAYGINDVQDIVYNPSYDTLYQEELNPGLEGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTLWWSDKGKGKNDNKPLSQETWQHLKGLVTHQLSGKRLFIVDAFCGANADTRLSVRFITEVAWQAHFVKNMFIRPTDEELVGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERIQLIGGTWYGGEMKKGMFSVMNYLLPLKGIASMHCSANVGEKGDVAVFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYHAIRRDALLENVTVREDGTVDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTANQTQYHFLSGFTAKLAGTERGVTEPTPTFSACFGAAFLTLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFRLPLFDLAIPTELPGVDTHILDPRNTYASPEQWQEKATALAKLFIENFEKYTDTPAGEALVSAGPKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPR4_YEAST
Sequence: MNSESREDMAINSIKLLAGNSHPDLAEQISKKLGIPLSKVGVYQYSNKETSVTIGESLRDEDVYIIQTGIGEQEINDFLMELLILIHACKIASARKITTVIPNFPYARQDKKDKSRAPITAKLVANLLQTAGADHVITMDLHASQIQGFFHIPVDNLYAEPSVLNYIRTKTDFDNAILVSPDAGGAKRVAALADKLDLNFALIHKERQKANEVSKMVLVGDVTNKSCLLVDDMADTCGTLVKACDTLMEHGAKEVIAIVTHGIFSGSAREKLRNSRLSRIVCTNTVPVDLDLPIADQIDISPTFAEAIRRLHNGESVSYLFTHAPV
What is the function of this protein?
5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis.  Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase 4, Phosphoribosyl pyrophosphate synthase 4.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: X_HBVD3
Sequence: MAARLCCQLDPARDVLCLRPVGAESRGRPFSGSLGTLSSPSPSAVPTDHGAHLSLRGLPVCAFSSAGPCALRFTSARRMETTVNAHQILPKVLHKRTLGLSAMSTTDLEAYFKDCLFKDWEELGEEIRLKVFVLGGCRHKLVCAPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: RL2_BUCAT
Sequence: MAVVKCKPTSPGRRHVIKVVNNELYKGKPYSLLLRKKSKSGGRNNNGRITTRHIGGGHKRAYRIVDFKRNKDDIGATVERFEYDPNRSSNIALILYKDGERKYILAPKGIKIGDTIISGLRAPIKTGNTLPLKNIPVGTFVHNVELKPGKGGQIARSAGSYVQLVAFDEEYATLRLRSGEMRKTQSNCRATIGEVGNSEHMLKVLGKAGASRWIGIRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGIQTKGKKTRKNKRTDKFILRHRRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RL7_HELHP
Sequence: MAISKEEVLDYIGNLSVLELSELVKAFEEKFGVSAAPTVVAGAVAGGAGGGAAAEEKTDFNVVLVDAGANKINVIKAVREITGLGLKEAKDATEQTPSTLKEGVSKEDAENFKKKLEEAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: K1755_HUMAN
Sequence: MDPPSLDTAIQHALAGLYPPFEATAPTVLGQVFRLLDSGFQGDGLSFLLDFLIPAKRLCEQVREAACAPYSHCLFLHEGWPLCLRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCIMIKCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINSDFEGNPLHNCLVASENGIAPVPWTKITSPEFVDDRPQVVNALCQAWGPLPLEALDLSSPQELHQASSPDNQVLPAQSLAKGKGRTYGSKYPGLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTSSGCTSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRACTKPESSEERPYNLGFRRKVNLKAPTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVSALQATQAQVPASIRAILFLGEKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLHLHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLHRYLQRLASEFPAEKLAAVGLQVASLSRAGLGQELWEEARIRHEEIRMLLEKALTHSSCPEAPAAHSARPERRGVAAKGQGVSVEVTSKGRWDQPPLDSLGMDHLPKSYWPPGPPRGEQNRTFQAGSPPQEAGQAAEAEDGKGSHKLPDPAREHLLATTFFRQQPPRQSQVPRLTGGSFSSEGTDSQTSLEDSPQTSPLASL
What are the official names of this protein?
Uncharacterized protein KIAA1755.
Protein: NAT_MYCSM
Sequence: MAMDLGGYLTRIGLDGRPRPDLGTLHAIVAAHNRSIPFENLDPLLGIPVADLSAEALFAKLVDRRRGGYCYEHNGLLGYVLEELGFEVERLSGRVVWMRADDAPLPAQTHNVLSVAVPGADGRYLVDVGFGGQTLTSPIRLEAGPVQQTRHEPYRLTRHGDDHTLAAQVRGEWQPLYTFTTEPRPRIDLEVGSWYVSTHPGSHFVTGLTVAVVTDDARYNLRGRNLAVHRSGATEHIRFDSAAQVLDAIVNRFGIDLGDLAGRDVQARVAEVLDT
What is the function of this protein?
Catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines.  Substrates include isoniazid, anisidine, and 4-aminoveratrole, and to a much lesser extent, p-aminobenzoic acid.
What are the official names of this protein?
Arylamine N-acetyltransferase, NAT.
What is the protein family that this protein belongs to?
Belongs to the arylamine N-acetyltransferase family.
Protein: SPIKE_IBVU3
Sequence: NLFGNNSYVYYYQSAFRPPDGWHLHGGAYEVVNVSTESSNAGTNGCTVGAIYWSKNFSAASVAMTAPQNGMSWSTGQFCTAHCNFTDFVVFVTHCYKSGPGSCPLTGLIPQNHIRISAMKSGSLFYNLTVAVTKYPRFKSLQCVNNMTSVYLNGDLVFTSNETKDVSAAGVHFKAGGPITYKVMREVKALAYFVNGTAQDVILCDGSPTGLLACQYNTGNFSDGFYPFTNSSLVKEKFIVYRESSVNTTLELTNFTFSNVSNATPNTGGVQTIQLYQTKTAQSGYYNLNFSFLSSFSYKASDYMYGSYHPSCKFRLETINNGFWFNPLSVSLGYGPIQGGCKQSVFANRATCCYAYSYNGPSLCKGVYRGELTKSFECGLLVFVTKTDGSRIQTRNEPFTLTQHNYNNITLDRCVEYNIYGRVGQGFITNVTNYAINYNYLADGGMAILDTSGAIDIFVVQGEYGLNYYKVNPCEDVNQQFVVSGGKLVGILTSRNETGSQPLENQFYIKIINGTRRSRR
What is the function of this protein?
S1 attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses spike protein family.
What are the subcellular locations of this protein?
[Spike protein S1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. S1 is not anchored to the viral envelope, but associates with the extravirion surface through its binding to S2 (By similarity).