PharMolix/UniProtQA huggingface dataset:
Protein: ERG2_SCHPO
Sequence: MKLTKFLTVFIPFIAGLIYYIQKYHLRSFYQFDPAKLQELSKQSIALYANDTKALLYDLSDRLVAEYGDLITPVNQDEWVHNNAGGAMGTMFILHASFSEYLIFFGTPIGTEGHSGVHMADDYFTILRGRQLAASANDLEARVYLPGDQHVHPWGHTAQYSMPSGEPCFALELAQGWIVSMLPFGFMDGLFSTIDFGTLYKTVYFTAGRMLKSVLMGKF
What is the function of this protein?
C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes by the late steps of the pathway (PubMed:18310029).  Erg2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (By similarity).  The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane.  Firstly, the squalene synthase erg9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids.  Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase erg1 and the lanosterol synthase erg7.  The lanosterol 14-alpha-demethylase erg11/cyp1 catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.  In the next steps, a complex process involving various demethylation, reduction and desaturation reactions catalyzed by the C-14 reductase erg24 and the C-4 demethylation complex erg25-erg26-erg27 leads to the production of zymosterol.  Erg28 likely functions in the C-4 demethylation complex reaction by tethering erg26 and Erg27 to the endoplasmic reticulum or to facilitate interaction between these proteins.  Then, the sterol 24-C-methyltransferase erg6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.  The C-8 sterol isomerase erg2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol.  The sterol-C5-desaturases erg31 and erg32 then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol.  The C-22 sterol desaturase erg5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain.  Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase erg4 to produce ergosterol (PubMed:18310029) (Probable).  In the genus Schizosaccharomyces, a second route exists between lanosterol and fecosterol, via the methylation of lanosterol to eburicol by erg6, followed by C14-demethylation by erg11/cyp1 and C4-demethylation by the demethylation complex erg25-erg26-erg27 (PubMed:8586261) (Probable).
What are the official names of this protein?
C-8 sterol isomerase erg2, Delta-8--delta-7 sterol isomerase erg22, Ergosterol biosynthetic protein 2.
What is the protein family that this protein belongs to?
Belongs to the ERG2 family.
Protein: RL34_HALH5
Sequence: MGKPTFQPNNRKRKKVHGFRARMSTKNGRKVLARRRKKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: THIC_PSEMY
Sequence: MSAQQQKNLSESAQVDQQSVQPFPRSQKVYVQGSRPDIRVPMREISLDVTPTDFGGEINAPVTVYDTSGPYTDPNVTIDVRKGLSDVRSAWIEDRGDTEKLPGLSSEFGQRRLNDAELSAMRFAHVRNPRRARAGHNVSQMHYAKKGIITPEMEFVAIRENMKLAEAREAGLLNEQHAGHSFGASIPKEITPEFVRSEVARGRAIIPANINHVELEPMIIGRNFLVKINGNIGNSALGSSIEEEVAKLTWGIRWGSDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVGGIAEDLTWELFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRVTGIVSRGGSIMAKWCLAHHKENFLYTHFEDICEIMKAYDVSFSLGDGLRPGSIADANDAAQFGELETLGELTKIAWKHDVQCMIEGPGHVPMQLIKENMDKQLECCDEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKDDVKTGIITYKIAAHAADLAKGHPGAQIRDNALSKARFEFRWEDQFNLGLDPDTARAFHDETLPKDSAKVAHFCSMCGPKFCSMKITQEVRDYAKEQRIDAVDLDAEQGMQAKAAEFKAQGSQLYQKV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: DXR1_BACAN
Sequence: MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATKELADTLRTRISTNTKITYGTDGLIAVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNGENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHKESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGITPAVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase 1, DXP reductoisomerase 1, 1-deoxyxylulose-5-phosphate reductoisomerase 1, 2-C-methyl-D-erythritol 4-phosphate synthase 1.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: NU2M_VARTI
Sequence: MNPIINLILLSSMIAGTILTMSSHHWVSAWLGLELNTLAIIPIISKTHHPRATEASTKYFLIQAASSALFLLSGITNAYSHGTWDMAHLTNTPSKIMLSVALATKLGLAPIHFWLPEVLQGTPMITALIITTWQKIAPMALLITTWNLIPPTITLIMGLLSTIIGGLGGLNQTQLRKMMAYSSIAHLGWMITITTITPSLALFNLTLYILLTTSTMLIMHLTLSKTLQNTMLIYSYSPTTASLFLLSLLSLGGLPPLSGFSPKWLILQELTTHHLTPLALLMAITALLSLMFYLRTSYISTMTIPPSTTPLKNTWRLKSNSNTSLLSSLILLSLFLLPITPLMIQ
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DXR_CLOBJ
Sequence: MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLKGMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCLRGNKKEEVKNIIVTASGGPFRGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVVHPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGKKGGVMPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: SYH_CUPNH
Sequence: MTQSENVAAAGGAKTEPKVRPAKALQGVKGMNDMLPADAPLWEHFENAARAMLRAYGYQQIRTPIVEHTQLFVRGIGEVTDIVEKEMYSFTDSLNGEQLTLRPEGTAAAVRATIEHNLLYDGPKRLWYTGPMFRHERPQRGRYRQFHQLGAEALGFAGPDVDAEIILMCQRLWDDLGLVGVRLELNSLGQAHERAAHREQLIKYLEGFQDILDDDSKRRLYTNPLRVLDTKNPALQEMAANAPKLIDFLGEESLAHFEGVQRLLKANNIPFKINPRLVRGLDYYNLTVFEWITDKLGAQGTIAGGGRYDPLIAQMGGKPAPACGWAMGIERIIELIREEGVVPDAAGCDVYLVHQGEAAAQQAMIAAERLRDAGLDVVLHASPDGKGGSFKSQMKRADTSGAAYAVIIGDDEVAAGVVQVKELRQREQAEGGGQQATVPAEGLVDYLIDAMVGASE
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURQ_ACTP7
Sequence: MSEKNLLTALSKMITEQRNPNSMNIDQLSALELVKVINQEDKQVPLAVEKCLAQIAQAVEKIVQAFQNGGRLVYIGAGTSGRLGVLDASECPPTYGVSSEMVVGIIAGGERALRHPIEGAEDNTEQGKAALQAVNFSQKDVLVGIAASGRTPYVIGALEYAKSLGATTVSIASNPNSAMAQIAEIAIDTVVGPEILTGSSRMKSGTAQKLVLNMLTTASMVMIGKCYSNLMVDVQASNEKLKARAIKIVMEATECDRTVAENTLKIAENNAKLAIMMILSDSDKTTAEQLLSKHHGKLRQALVN
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: UBIA_XANC5
Sequence: MSKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLLVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVLTLNWLTVALSVPGVFLAASYPYLKRHTHLPQVYLGMAFGWGIPMAFAAVQGRVPLLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVLVGLRADLGVAYWAGLAVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAGR
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPG_STRGG
Sequence: MTAISLGMPAVPTKLADRRVSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQPKYVFAAIDAGCAAVRVNPGNIKQFDDKVKEIAKAASETRTPIRIGVNAGSLDARLLKKYGKATPEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVNAYRQLAAQSDYPLHLGVTEAGPAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPAEEVKVGLQILEALNLKQRRLEIVSCPSCGRAQVDVYKLADQVSAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEALKIAEQMEKDGIASGEPQVSIGA
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: ACL7A_RAT
Sequence: MSLDAVWAPQTANIGDGPAKKASDQTSMQTQVLQTASLRDGPAKRAVWVRRDNAEKEEPVKSAVSKDRPRLEVTKAVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGRELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTNYLMNLMNNCGKHFSEDHLSIVEDIKTKCCFVALDPIEEKKIPPSEHEIHYTLPDGKEIRLGQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTPQVNVLPERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF
What is the function of this protein?
May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
What are the official names of this protein?
Actin-like protein 7A.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Nucleus. Note=Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail.
Protein: RL6_STAA9
Sequence: MSRVGKKIIDIPSDVTVTFDGNHVTVKGPKGELSRTLNERMTFKQEENTIEVVRPSDSKEDRTNHGTTRALLNNMVQGVSQGYVKVLELVGVGYRAQMQGKDLILNVGYSHPVEIKAEENITFSVEKNTVVKVEGISKEQVGALASNIRSVRPPEPYKGKGIRYQGEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RS10_YERPA
Sequence: MQNQRIRIRLKAFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHKRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: CSP1_CAEEL
Sequence: MVLKTIEDNCKSQFDDDLVEDFNNFQTTSSMSSSTTISTEDFNTIEIESTFEICRSGSYTEEPILGENDEFLIDFEMERFLKFLKDKTKQVEKRKEPFSQKEIYAVFQRRIKSELCIETVKKKFQPLLPNAIQTCEFDEETMIRMIYGAGIRIDSVDFWNRFTSKATISLDCYSRLISYSSDSLTLSGTHRSGFTYHWISTPPVTYHRTENKDPNIQEPSPVEFLDVQSSLGSSMKPPILDKPTKLDDPAETRHDCSYSLEEYDSQSRMPRTDAKKSNHKHKYCYEMNSNPRGTVLILSNENFKNMERRVGTKQDEVNLTKLFQKLQYTVICKRNLEAESMLEAIKEFAEMAHTDSIILFLLSHGDGAGSVFGIDDMPVNVMEVSTYLAYHQNLLLKPKWVAVSACRGGKLNMGVPVDGLPALEDKCAPISKFWNLMMSRIMPGTFTSLNADVIISFSTTDGFTSYRDEEAGTWYIKSMCKVFNKHSKTMHLLDILTETGRNVVTKYENVQGNVVLKQAPEILSRLTKQWHFSRSM
What is the function of this protein?
Dispensable for regulating apoptosis during embryogenesis.
What are the official names of this protein?
Caspase A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
Protein: HEMA_I73A1
Sequence: MNTQILILAISAFLCVRADKICLGHHAVSNGTKVDTLTEKGIEVVNATETVEQKNIPKICSKGKQTIDLGQCGLLGTTIGPPQCDQFLEFSANLIIERREGDDICYPGKFDNEETLRQILRKSGGIKKENMGFTYTGVRTNGETSACRRSRSSFYAEMKWLLSNTDNGVFPQMTKSYKNTKREPALIIWGIHHSGSTAEQTRLYGSGNKLITVWSSKYQQSFAPNPGPRPQINGQSGRIDFYWLMLDPNDTVTFSFNGAFIAPDRASFLRGKSLGIQSDAQLDNNCEGECYHIGGTIISNLPFQNINSRAIGKCPRYVKQKSLMLATGMKNVPENSTHKQLTHHMRKKRGLFGAIAGFIENGWEGLIDGWYGYRHQNAQGEGTAADYKSTQSAINQITGKLNRLIEKTNQQFELIDNEFNEIEKQIGNVINWTRDSIIEVWSYNAEFLVAVENQHTIDLTDSEMNKLYEKVRRQLRENAEEDGNGCFEIFHQCDNDCMASIRNNTYDHKKYRKEAIQNRIQIDAVKLSSGYKDIILWFSFGASCFLFLAIAMVLAFICIKNGNMRCTICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: SURA_BUCAI
Sequence: MKICIFIFFYIFSSIFYVLAKNNQVDNITAIVNDEIILNSDVNEILVFLKKSKKKFIIPLKSDFLKEKVLEKLIVDSLILQEANSKNINITKEQIDTVIKNIALKKHISVDHFKKQILLRNIKNPSYYDNFIKKIEILLKMKTIQDYELHKRINISEQEVNTIFKKLIKDNEKFKKINLSYILLPSLKQDSDNAVRNRTKIAENIVYKLKKGYDFEKLLIECEKNKSTFIVKKMFWKPLLDIQNSFFKTLNIFKKGQILGPIVGDKGLYILKVNDIHHKKENIVTEFYMQHCLIKPSVILTNTEAKKKIFNIYENIKKGIYTFDDAVKNLSDDYYSSNKKGDLGWISKESLGFDLNKKFLILDKNEISEPVKSNWGWHIFKILDRRQVDAFYKLKKNQAFNIVLNQKIISEKNHWIEDLKNTAYIEIIRS
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity).
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: ATPD_CALBD
Sequence: MLAAKRYAEALIKLGQEEGKLEIFYEQLFKMFEIIKNNNEFNTIWFDLEMKRSEKKQRIKVFFGGDIDSYILNLLYLLIDKRREIILTYIPFYYKEIYDKIVGNVDVQVIVAHEIGSDVLNKISKWLLKKYGVKNPRFIVKVDKSIIGGIKLLFNNIEVDASIKGALDSMRKELVKIAIL
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y176_UREPA
Sequence: MIYVLYSPNCAVCKKVVRFFRNNQIEITKIIIGEDKIERSMLLDILSLCEDGFGTIISFKTESSKRLNITSKTFLDLSTKELLNLIQNDLNLIRRPLIYQTKNNRPYRLQIGYDSEEIEIFKRAVHEK
What are the official names of this protein?
Uncharacterized protein UU176.
What is the protein family that this protein belongs to?
Belongs to the ArsC family.
Protein: RS15_SHEPA
Sequence: MSLSVEAKAQILAEFGRCENDTGSSEVQVALLTAQINHLQGHFKEHIHDHHSRRGLLRMVSTRRKLLAYLKRTENVRYQELIKKLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: TRPB_METCA
Sequence: MIMQDEIQPYDLPDELGHFGPYGGIFVAETLMEPLEELKAAYHRYLKDPEFLAELDHDLNHYVGRPSPIYHAERLSRELGGAQIFFKREDLNHTGAHKVNNTVGQALLAKRMGKRRVIAETGAGQHGVATATVAARLGMECVVYMGAVDVQRQALNVFRMKLLGATVIAVDSGSRTLKDALNEAMRDWVTNVDDTFYIIGTVAGPHPYPAMVRDFQAVIGREARRQMLEMTGRLPDALVACVGGGSNAIGLFHPFVDDREVAMYGVEAAGDGIETGRHSAPLSAGRPGVLHGNRTYLMEDEDGEIIETHSISAGLDYPGVGPEHAWLKDCGRASYVSATDAEALEAFHILTRSEGIIPALESSHAVAYALKLAPTLSSDKIVLVNLSGRGDKDIHTIATREGIVL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: NSP5_ROTW3
Sequence: MSLSIDVTSLPSISSSIYKNESSSTTSTLSGKSIGRSEQYISPDAEAFSKYMLSKSPEDIGPSDSASNDPLTSFSIRSNAVKTNADAGVSMDSSTQSRPSSNVGCDQVDFSFNKGIKMNANLDSSISISTISKKEKSKSDHKSRKHYPKIEAESDSDDYVLDDSDSDDGKCKNCKYKRKYFALRMRMKQVAMQLIEDL
What is the function of this protein?
Plays an essential role in the viral genome replication.  Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories.
What are the official names of this protein?
Non-structural protein 5, NSP5, NS26.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP5 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: Y694_METJA
Sequence: MIYVTFTPYGAFGVKDNKEVSGLEDIEYKKLFNEEEIPDIMFKLKTQPNKIADELKEEWGDEIKLETLSTEPFNIGEFLRNNLFKVGKELGYFNNYDEFRKKMHYWSTELTKKVIKSYAQQKDKIIIQVAEAISDLDKTLNLLSERLREWYSLYFPELDHLVNKHEVYANLITKLGKRKNFTKSQLKKILPSKLAGKIAEAAKNSMGGELEDYDLDVIVKFAEEINHLYEKRKELYNYLEKLMNEEAPNITKLAGVSLGARLIGLAGGLEKLAKMPASTIQVLGAEKALFAHLRMGVEPPKHGIIYNHPLIQGSPHWQRGKIARALACKLAIAARADYVGDYIADELLEKLNKRVEEIRRKYPKPPKKKKKEKPKAKKKEKKGKKEKSKKKKDKKKDKKGKKERKVIGKTKSRK
What are the official names of this protein?
Uncharacterized NOP5 family protein MJ0694.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
Protein: ILVC_KLEP3
Sequence: MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRSVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVAEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKEFMTTLQTGDLGKAIAEGAVDNAQLRDVNEAIRSHAIEQVGKKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SYGB_ECOLU
Sequence: MSEKTFLVEIGTEELPPKALRSLAESFAANFTAELDNAGLAHGTVQWFAAPRRLALKVANLAEAQPDREIEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLTTDKGEWLLYRAHVKGESTEALLPNMVATSLAKLPIPKLMRWGASDVHFVRPVHTVTLLLGDKVIPATILGIQSDRVIRGHRFMGEPEFTIDNADQYPEILRERGKVIADYEERKAKIKADAEEAARKIGGNADLSESLLEEVASLVEWPVVLTAKFEEKFLAVPSEALVYTMKGDQKYFPVYANDGKLLPNFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFNTDRKKRLEDNLPRLQTVLFQQQLGTLRDKTDRIQALAGWIAEQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLNLDLQTLTEEAVRLYGDKLTNANVVDDVIDFMLGRFRAWYQDEGYTVDTIQAVLARRPTRPADFDARMKAVSHFRTLDAAAALAAANKRVSNILAKSDEVLSDRVNASTLKEPEEIKLAMQVVVLRDKLEPYFAEGRYQDALVELAELREPVDAFFDKVMVMVDDKELRINRLTMLEKLRELFLRVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCED_STAAB
Sequence: MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNYTFDYEGFTYHFESDGTHFAWNYHATGANGADMSAQAPATNNVAPSADQANQVQSQEVEAPQNAQTQQPQASTSNNSQVTATPTESKASEGSSVNVNDHLKQIAQRESGGNIHAVNPTSGAAGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
What is the function of this protein?
Is able to cleave peptidoglycan and affects clumping and separation of bacterial cells.
What are the official names of this protein?
Probable transglycosylase SceD.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase family. SceD subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YIDD_NITEC
Sequence: MKQLIIGLIKLYQYSIGLLIPPSCRFYPTCSNYMREALTKHGLIKGLWLGTRRILRCHPWNPGGYDPIP
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.