PharMolix/UniProtQA huggingface dataset:
Protein: SYE_BORGP
Sequence: MSIRVRYAPSPTGLQHIGGIRTALFNYFFAKSCGGKFLLRIEDTDQSRYFPEAENDLYSSLKWLGISFDEGPIVGGDYAPYVQSQRSAIYKKYAKYLIESGHAYYCYCSPERLERIKKIQNINKMPPGYDRHCRNLSDDEVENALIKKINPVVRFKIPLEGETSFDDILLGKITWSNKDISPDPVILKSDGLPTYHLANVVDDYLMKITHVLRSQEWVSSGPLHILLYKAFEWKSPIYCHLPMVMGNDGQKLSKRHGSTALRQFIEDGYLPEAIINYVTLLGWSYDDKREFFSKNDLEQFFSIEKINKSSAIFDYHKLDFFNSYYIKEKKDEDLYNLLLPFFQKKGYVSELITLEESQKLKLLIPLIKNRIKKLSDALNMTKFFYEDIKSWNLDEFLNRKKTAKEVCYILELTKPILEGFEKRSSEENDKIFYDFAENNGFKLGEILLPIRIAALGSKVSPPLFDSLKLIGKSKVFKRIKLAQEFLRINE
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAL1_LIMF3
Sequence: MNQQELFDKYQDTFAAQGQDLFFSPGRINVIGEHTDYNGGHVFPCAISLGTYGVYGVRDDDQVQLFSGNMEGDVVSFAITDEAPEEAEDRKWANYFKGMLVYLRQKGFKIDHGFNLYVYGNLPYGAGLSSSASIEMLMGQVLKDEFNLDIDQIDLVKLGQKTENDFVGLNSGIMDQFAVGMGKKDNAIFLDCNTLEYKYMPLELGDYEIVIMSTNKKHSLAASAYNDRVAECGEALKRLQTKLDINSLGEIDEDTFDEYSYLLNDETLLKRTRHAVFENQRTIQATKAMTDGDLEKLGRLINASHVSLHFDYEVSGTELDTLAEAAWQQPGVLGARMIGGGFAGSAIAIVKKDQAENLKQKVGEIYREKVGYDASFYDAEIVDGPHKL
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MKCB_DICDI
Sequence: MKSILKKAKHFFHTNETVNGENGGEKTAKESESQQHHQQQQQHDENGANPPDQGVDEASNVSQSQPTTSALQTSTSLQPSSSLHQIPQSQSSLELTTNPTQQLPTTPTKQLPTPPPPQQPHSQQQQQQQQQSQSQLNNNDISISTNTNNTTNNTNNNNNIDSTLTTPVPSSENLATLSTSTTSEQQPNSQPTPNNTNTTTSPPPSSASTSNLSTSTTTTTTTTTTTTAAANENTNTTQEQTVSPNKPPQPPNALSQSTTSSSTSSTSLLSSTFSKFKIKLGSGSTKNKDSSSAPGTPHINNNNNTVSSSNKNRSTLVITPGSVNNNNNNQNNHKNNNTTPDHPPEEQKPVEKEVITIATLADFPEDCQKLIRISGIPEEKLIKNIQILAYVLHFRTGRFFKLVDEPPREPRKKFVSERFNDGEKLLEPVEPALLKKMYKDSDQVGKGGFGTVYFAKSTKEKRLVAIKKMPHVTKRQQQQNFREAAILAKCDHPNIVKLHTCHIDKDSNLWIVMEFMEGGTFEEAAKAWKFNENNLAYVAKELLKGLQYLHENHMVHRDLKSANIMMSVEGKVKLIDFGLCEDVATSTPMHMVGSPFWMAPEMIQQKYHSTPVDIWSFAISLLEMANQRPPMMESAVKAMFTVATDGATGFDDPALWSDCFKDFLSLCLKQDPAERATAEELLKHPFIKKADSRDNMENILKKIFLTNSLMNSGF
What are the official names of this protein?
Probable serine/threonine-protein kinase mkcB, MAP kinase cascade B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Protein: METAA_ALKCL
Sequence: MRERVAMPIKIPDHLPAKEILLKENIFIMDESRAYTQDIRPLKICILNLMPTKQETETQLLRLLGNTPLQVDVSLLHPSTHSPRNTSKEHLNLFYKTIDEVKQQKFDGMIITGAPVETLPFHDVNYWNEMTSILDWTTTNVTSTLHICWGAQAGLYHHYGIKKKPLTTKLFGVYSHKLEVKNVNLLRGFDDVFYAPHSRHTTVSREDIERVDELIVLSSSEEAGVYIASSKDGKRVFVMGHSEYDAHTLKQEYERDVKRGIACDPPFNYFPEGNVDALPPLQWRAHSNLLFSNWLNYYVYQETPYHLDD
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.  In vitro, can also use propionyl-CoA as acyl donor.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGC_ECOSM
Sequence: MNPVPAQREYFLDSIRAWLMLLGIPFHISLIYSSHTWHVNSAEPSLWLTLFNDFIHSFRMQVFFVISGYFSYMLFLRYPLKKWWKVRVKRVGIPMLTAIPLLTLPQFIMLQYVKGKAESWPGLSLYDKYNTLAWELISHLWFLLVLVVMTTLCVWIFKRIRNNLENSDKTNKKFSMVKLSVIFLCLGIGYAVIRRTIFIVYPPILSNGMFNFIVMQTLFYLPFFILGALAFIFPHLKALFTTPSRGCTLAAALAFVAYLLNQRYGSGDAWMYETESVITMVLGLWMVNVVFSFGHRLLNFQSARVTYFVNASLFIYLVHHPLTLFFGAYITPHITSNWLGFLCGLIFVVGIAIILYEIHLRIPLLKFLFSGKPVVKRENDKAPAR
What is the function of this protein?
Necessary for the succinyl substitution of periplasmic glucans.  Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.
What are the official names of this protein?
Glucans biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase 3 family. OpgC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: END4_LATSS
Sequence: MLLGSHVSMKGKEMLLGSAQQAAEFGANTFMIYTGAPQNTRRKPIEELNIPAAQALIAAKNLGPIVVHAPYIVNLGNTVKPENFKFAIEFLQQEVIRAEALGASQIVLHPGAHVGAGADAGIKQIIKGLNEILRPDQTAQIALETMAGKGTEVGRRFEEIAQMIDGVTLNDKLSVTFDTCHTSDAGYNIREDFDGVLNEFDHIIGLDRLKVIHLNDSKNPQGAHKDRHANIGFGEIGFDALHGVVTHPQLVDVPKIMETPYVGKDKKHNFAPYAYEIAMLKKGEFDPDLLTKIEQNEGRL
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: RUBR2_PSEAE
Sequence: MRKWQCVVCGFIYDEALGLPEEGIPAGTRWEDIPADWVCPDCGVGKIDFEMIEIA
What is the function of this protein?
Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
What are the official names of this protein?
Rubredoxin-2, Rdxs.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARCA_STRS7
Sequence: MTAQTPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQALRDEGVEVLYLETLAAESLVTPEIREAFIDEYLSEANIRGRATKKAIRELLMSIEDNQELIEKTMAGVQKSELPEIPAAEKGLTDLVESSYPFAIDPMPNLYFTRDPFATIGTGVSLNHMFSETRNRETIYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKQKLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRVYSVTYENEELRIVEETGDLAELLAANLGVEHVELIRCGGDNLVAAGREQWNDGSNTLTIAPGVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDC_PONAB
Sequence: MLRKVTVAAVCATRRKLCEAGRELAALWGIETRGRCEDSAAVRPFPILAMPGRNKAKSTCSCPDLQPNGQDLGENSRVARLGADESEEEGRRGSLSNAGDPEIVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEEDDDEDSGAEIEDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEERAEARKKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWLRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQPYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQRSAANVVLFDIFANILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIVDYLAEFNSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRSTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVVGYGKYELEEDGTPSSEDSNSSCEVMQLTYLPTSPLLADCIIPITDIRAFTTTLNLLPYHKIVK
What is the function of this protein?
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.  Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination.  Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity).
What are the official names of this protein?
Nardilysin, N-arginine dibasic convertase, NRD convertase, NRD-C, Nardilysin convertase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
Protein: RUVA_SHIF8
Sequence: MIGRLRGIIIEKQPPLVLIEVGGVGYEVHMPMTCFYELPEAGQEAIVFTHFVVREDAQLLYGFNNKQERTLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGPLVKLPGIGKKTAERLIVEMKDRFKGLHGDLFTPAADLVLTSPASPATDDAEQEAVAALVALGYKPQEASRMVSKIARPDTSSETLIREALRAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: TRPF_CELJU
Sequence: MKSLHIKICGLTSLVDARAAVAAGADAIGLVFYAPSPRAVSVAQARAIALGIGPFTVATGLFVDADPGFVQSVLAEVPLQLLQFHGSESRAYCESFQRPYMKAIRMRPELDVVAAMAEYPSASAILLDAYRPGVPGGTGETFDWGRVPQHTSRPLVLAGGLAPENVANAISATRVYGVDVSGGVESAPGVKDHEKIHRFITCALQASAQLNSKGD
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: Y1336_METJA
Sequence: MGYNQQLLRVDYEKIYPINDELSSKILGVIKNLNGKSDILVISDYAKGLITKELMDDIKKEFKGKILIDPKPKNDFYKDVYLIKPNLKEASQILGREIENKDDELEKSGLESVDKYNSNFVITRGEKGATLITVDEIFTMFQQKSKRS
What are the official names of this protein?
Uncharacterized protein MJ1336.
Protein: BIOA_LYSSH
Sequence: MKQVLTELQEKDLQHVWHPCSQMKDYEAFPPIVIKKGEGVWLYDEQNQRYLDAVSSWWVNLFGHANPRISQALSEQAFTLEHTIFANFSHEPAIKLAQKLVALTPQSLQKVFFADNGSSAIEVALKMSFQYHMQTGKTQKKRFLALTDAYHGETLGALSVGGVDLYNEVYQPLLLDTVRAQGPDCFRCPFKHHPDSCHAQCISFVEDQLRMHHKEITAVIIEPLIQAAAGMKMYPAIYLRRLRELCTQYDVHLIADEIAVGFGRTGTLFACEQANISPDFMCLSKGLTGGYLPLSVVMTTNDVYQAFYDDYATMKAFLHSHSYTGNTLACRVALEVLAIFEEEQYIDVVQDKGERMRKLALEAFSDLPFVGEYRQVGFVGAIELVANRDTKEPLPSEERIGYQIYKRALAKGLLIRPLGNVLYFMPPYIITDDEMQFMIQTTKDTIVQFFEEREG
What is the function of this protein?
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA).  It is the only aminotransferase known to utilize SAM as an amino donor.
What are the official names of this protein?
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, 7,8-diamino-pelargonic acid aminotransferase, DAPA AT, DAPA aminotransferase, 7,8-diaminononanoate synthase, DANS, Diaminopelargonic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPB31_MYCTU
Sequence: MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLELNSRK
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Upon expression in M. smegmatis neutralizes the effect of cognate toxin VapC31.
What are the official names of this protein?
Antitoxin VapB31.
Protein: MEU6_SCHPO
Sequence: MSYEGREERPEQIAEPTFENVSEHNEHDSGSAEAQVETLEVPLSNETDNDDATENAVPAEVQAPEEPKEPETVDNIDPADDDPNSVAAPKVEEKKSKKKAKDEKPLTYTTGGYLYCRSNGLIPHVMKRYFYMLEGPMSMDLLDHYYKKHFHGTLQGNPTEPSLASEQMHDSDADSLFQSANDHLNRIAKATQDCRGLLFYSKSQSTSVPSGIINLTDAVSIEPGTGNKFTINFNNGKSETLEALDPESKNTWITDLKNAIAKKKETKDKIKELRAYNDTLKRLGKLAARSGPSASETFRYFLPMLSNGRDAKKSSSKSHGGKQNNSVAKDGLFDFFQNMIKGKTPQNDTASPIDNETSADPVDTTVEAQSVEVPENETNQIPTTEEHFPATTEEVAPASEEKPATGPAEESTSTQNVEQASTQNDNGTPIGQIADAIEEDVKGTAQSVEQAFIEETDIALPDIALPDVATPTADDQDPSTAATNEESVVSNEDRTSKKAGKKHHRHHKKKKGGNKRVFGFKLHKYAKPTKSVKTLQADPSLEFAKAGFEIFPSNLSKKLSGLVQKKVHKKFDKDGRLKEISQFSKTTIKPETPLTPTTTPTPRTAAQEDPAEETTDALASAEGENNQMPQVLETEAAPSIASEGRSITVNA
What are the official names of this protein?
Meiotic expression up-regulated protein 6.
Protein: XYPA_MYCS2
Sequence: MNITSKIGAIAAAGAVGLGLTACGAGDTAANSDTKRIGVTVYDMSSFITEGKEGMDTYAKANNIELVWNSANNDVSTQASQVDSLINQGVDAIIVVPVQADSLGPQVASAKSKGIPLLAVNAALETPDLAGNVQPDDVAAGAQEMQMMADRLGGKGNIVILQGPLGGSGEINRGKGIDQVLAKYPDIKVLAKDTANWKRDEAVNKMKNWISSFGPQIDGVVAQNDDMGLGALQALKEAGRTGVPIVGIDGIEDGLNAVKSGDFIGTSLQNGTVELSAGLAVADALVKGEDVKTDPVYVMPAITKDNVDVAIEHVVTERQKFLDGLVELTQQNLKTGDIAYEGIPGQTQP
What is the function of this protein?
Part of an ABC transporter complex likely involved in xylitol import.  Binds xylitol.
What are the official names of this protein?
Xylitol-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 2 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: LA1D_UROYA
Sequence: MERILKPVFLAILIVLSFSSQCMGFGESCQAGKHIVPVGQQQIDSSTCTLYKCSNYNRKYALETTSCATLKMKSGCRMVPGAATAPFPNCCPMMMCKG
What are the official names of this protein?
La1-like protein 13.
What is the protein family that this protein belongs to?
Belongs to the scorpion La1-like peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNFD_CROS8
Sequence: MVFRIASSPYTHNQRQTSRIMMLVTLATVPGIAVQWYFFGYGSLVQILLAIVSALASEALVIRLRKLPLKSHLGDNSALLTGLLLGVSIPPLAPWWMVVLGTAFAVIIAKQLYGGLGHNPFNPAMIGYVVLLISFPVQMTNWLPPQQIAATAPGFLDALQVIFHGVTASGDTMSQLRLGIDGVSQATPLDTFKTGLHAGHPAGELLAQPIYGGALAGLGWQWVNLAYLAGGLFLLARGTIRWHIPVSFLVTLAVCSTLGWLIAPEKFLSPLMHLLSGATMLGAFFILTDPVTASTTNKGRLVFGALVGLLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHR
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GSTT1_MUSDO
Sequence: MDFYYLPGSAPCRSVLMTAKALGIELNKKLLNLQAGEHLKPEFLKINPQHTIPTLVDGDFALWESRAIMVYLVEKYGKTDSLFPKCPKKRAVINQRLYFDMGTLYKSFADYYYPQIFAKAPADPELFKKIETAFDFLNTFLKGHEYAAGDSLTVADLALLASVSTFEVASFDFSKYPNVAKWYANLKTVAPGWEENWAGCLEFKKYFG
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 1, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
Protein: DRS12_PHYSA
Sequence: ASLKKSLFLVLFLGLVSLSICEEEKRENEDEENQEDDEQSEMRRGLWSKIKEAAKTAGKMAMGFVNDMVGEQ
What is the function of this protein?
Antibacterial peptide with activity against Gram-positive and Gram-negative bacteria (By similarity).  May also be active against fungi (Probable).
What are the official names of this protein?
Dermaseptin-S12, DRS-S12.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: NRAM2_HUMAN
Sequence: MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTCHLGLTAQPELYLLNTMDADSLVSR
What is the function of this protein?
Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:22736759, PubMed:25491917, PubMed:17293870, PubMed:25326704).  Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:22736759, PubMed:25491917, PubMed:17293870, PubMed:25326704).  Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity).  Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (PubMed:24448823) (By similarity).  Can mediate uncoupled fluxes of either protons or metal ions.
What are the official names of this protein?
Natural resistance-associated macrophage protein 2, NRAMP 2, Divalent cation transporter 1, Divalent metal transporter 1, DMT-1, Solute carrier family 11 member 2.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
[Isoform 2]: Cell membrane; Multi-pass membrane protein. Early endosome. SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Also found in extracellular vesicles different from exosomes.
Protein: PIS4A_DANRE
Sequence: MAAELVEAMNMVKSFRVSDLQTLLASMGRSKSGLKQDLVGRALRLVQTEYSPELLKNVRQLYETRFPKASAWLAARRPETVAVNYPALNSSPRGTGQGTDYLNGIPKPAPPPAAEVKLVPLPFYHNLETLLPPTELVAQNSEKLQESQCVFDLTPNQVDQIRNSSELRPGMKSVQVVLRICYTDSIGVQEDQYPPNIAVKVNQSYCHVPGYYPSNKPGVEPRRPCRPVNITPWLHLSTVTNRVTITWGNFGKRYSVAVYLVRVFTSGELFNQLKHCSVENPDRCRERIQDKLRFDPESEIATTGLRVSLICPLVKMRLGVPCRVLTCAHLQCFDAVFFLQMNEKKPTWTCPVCDKPAPFELLTIDGLLSEILKETPEDVEEIEYLTDGSWRPIRDDKEKERERENSRTPDYPVVDICVPEANGHSPAHSGTNQTGKSGSGGASAGTGSTSGGSGGGTVVDLTLDDSSEEEGGGGAEDSEETDDSQDSPAPKRGRYDYDKDLVTAY
What is the function of this protein?
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase (By similarity).  May play a role as a transcriptional coregulator in various cellular pathways (By similarity).  Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity).  Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin (By similarity).  Negatively regulates induction of interferon phi 1 (ifnphi1) mediated by mavs and ticam1/trif.  Also inhibits ifnphi1-mediated activation of the interferon-stimulated genes (ISGs) pkz and cd40, and to a lesser extent rsad2 and isg15 (PubMed:22345667).  May inhibit ticam1/trif-mediated activation of NF-kappa-B (PubMed:22345667).
What are the official names of this protein?
E3 SUMO-protein ligase PIAS4-A, Protein inhibitor of activated STAT protein 4.
What is the protein family that this protein belongs to?
Belongs to the PIAS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ASTD_ECOSE
Sequence: MTLWINGDWITGQGASRVKRNPVSGEVLWQGNDADAAQVEQACRAARAAFPRWARLSLAERQVVVERFAGLLERNKGELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHVRTGEQRSEMPDGAASLRHCPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGEAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHRQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLLLKSGAQGDAFLARLVAVSQRLTPGNWDDEPQPFIGGLISEQAAQQVVTAWQQLEAMGGRTLLAPRLLQSETSLLTPGIIEMTGVAGVPDEEVFGPLLRVWRYDSFEEAILMANNTRFGLSCGLVSPEREKFDQLLLEARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLPATLNPGLDFSDEVVR
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: PSTB_SHIBS
Sequence: MSMVETAPSKIQVRNLNFYYGKFHALKNINLDIAKNQVTAFIGPSGCGKSTLLRTFNKMFELYPEQRAEGEILLDGDNILTNSQDIALLRAKVGMVFQKPTPFPMSIYDNIAFGVRLFEKLSRADMDERVQWALTKAALWNETKDKLHQSGYSLSGGQQQRLCIARGIAIRPEVLLLDEPCSALDPISTGRIEELITELKQDYTVVIVTHNMQQAARCSDHTAFMYLGELIEFSNTDDLFTKPAKKQTEDYITGRYG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ADCY6_CANLF
Sequence: MSWFSGLLVPKVDERKTAWGERNGQKRPRRGTRTSGFCTPRYMSCLRDAQPPSPTPAAPPRCPWQDEAFIRRGGPGKGTELGLRAVALGFEDTEAMSAVGAAGGGPDVTPGSRRSCWRRLAQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAATLFVALMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAANPRSPSVGLWCPVFFVYITYTLLPIRMRAAVFSGLGLSTLHLILAWQLNRGDAFLWKQLGANMLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLPDENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAARAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLVFPHSTVMLGIYASIFVLLLITVLTCAVYSCGSLFPKALRRLSRSIVRSRAHSTVVGIFSVLLVFTSAIANMFTCNHTPIRTCAARMLNVTPADITACHLQQLNYSLGLDAPLCEGTAPTCSFPEYFVGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPSTIFDNYDLLLGVHGLASSNDTFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQAGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKRYQLECRGVVKVKGKGEMTTYFLNGGPPS
What is the function of this protein?
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:1528892, PubMed:17110384).  Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption.  Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion.  Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity).  Signaling mediates cAMP-dependent activation of protein kinase PKA (By similarity).  This promotes increased phosphorylation of various proteins, including AKT.  Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility.  May contribute to normal heart function (By similarity).  Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (By similarity).  Contributes to bone cell responses to mechanical stimuli (By similarity).
What are the official names of this protein?
Adenylate cyclase type 6, ATP pyrophosphate-lyase 6, Adenylate cyclase type VI, Adenylyl cyclase 6, Ca(2+)-inhibitable adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cell projection, stereocilium.