PharMolix/UniProtQA huggingface dataset:
Protein: SPX3_XENLA
Sequence: MDFPVNTRRMAGRRGFFSQYTHHHLAAFLLTFFSYSLLHASRKSFSNVKVSVSSQWTPSDLNSSAYIVLPNETWNGNTLFPNTKSATLFLGLLDTIFLFAYAVGLFISGIIGDRLNMRLVLTFGMCSSAITMFVFGTLTEWLQFYNKIFYCLVWIVNGLLQSTGWPCVVAIMGNWFGKSGRGFVFGLWSACASVGNILGAFLASSVLKYGYEYAFLVTASVQFAGGIIIFFGLVTSPKELGLPDTGEGEMDRAAQEEGANKPLIGGNDEGDDESNYSIQSDDVVITPKAIGFMQACCLPGVLLYSLAYACLKLVNYSFFFWLPYYLSNNFKWKEAEADQLSIWYDIGGIVGGTVQGLISDLMKMRSPVLTVSLLLAVGALFGYSHSPNDKVMNAFIMSITGFFIGGPSNMISSAISADLGRQEMVRGSSEALATVTGIVDGTGSIGAAMGQFLVPLIQNSLNWMWVFYFFIFMICMTTVFMVPLIVRETRDWLRQRRSSRLER
What is the function of this protein?
Unlike the other SLC37 members, seems to lack glucose-6-phosphate antiporter activity.
What are the official names of this protein?
Sugar phosphate exchanger 3, Solute carrier family 37 member 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL20_XANC8
Sequence: MARVKRGVQARRRHKKILTLAKGYYNARRKVFRVAKQAVIKAQQYAYIGRKQKKRNFRSLWITRINAAARINGLSYSRFMNGMLKAGITLDRKVLADIAVHDAAGFAALAEKAKGALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NTPPA_ALCBS
Sequence: MILYLASGSPRRAELLQQIAVPFTVLPAPSIDETPRSAEAAVDYVRRMAREKALVGQARMPTPGAVLGADTAVVLGDQILGKPADDTEALAMLTQLSGTSHQVISAVCVCSEGRQAVRHTVTTVQFRPFEAARLEVYVATGEGRDKAGSYGIQGLGGALVESLSGSYSGVVGLPLEQTVELLEWADIPYWQID
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_STRTD
Sequence: MAIIMDGKALAVNMQEQLQEKVARLKEKEWIVPGLVVIMVGENPASQVYVRNKERAAKKAGFHSKTVNLSESISEEELIEVIEKYNQDPLFHGILVQLPLPNHINEMRILLAVDPKKDVDGFHPMNTGNLWNGRPQMVPCTPAGIMEILREYNVELEGKTAVIIGRSNIVGKPMAQLLLEKNATVTLTHSRTPHLAKVCNKADVLIVAIGRAKFVTEEFVKEGAVVIDVGINRDEEGKLCGDVDFDQVKEKVSMITPVPGGVGPMTITMLMEQTYQAALRSLKG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: MENG_BACSU
Sequence: MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMNVKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIELLHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMFGFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKYHSFTGGVAATHIGWK
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: COBT_METSB
Sequence: MLADAAPLDSIRHLIGKMPPASERAAAAARARQAELTKPQGSLGRLEEIAAFLASWQGKPSPTLDRPLVAVFAANHGVVAKGVSAYPPSVTRAMMQNFSAGGAAINQICGAFGVGLKVFELALDIPTKDITEEPAMEAAETAATFAFGMEAIDGGVDLLCVGEMGIGNTTVAAAIFYALYGGSAADWVGRGAGVEGEALARKMAAVETAVALHRPFLSDPLEVMRRLGGREIAAMAGAIVAARMQNIPVVLDGYVVCAAAAILHAVDKSALDHCLAGHLSAEGAHGEVLRRLGKIPLLDLGMRLGEGSGAALAVGLIKAAVACHTGMATFAEAQVAGKVGG
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: MNHG2_STAA2
Sequence: MEITKEIFSLIAAVMLLLGSFIALISAIGIVKFQDVFLRSHAATKSSTLSVLLTLIGVLIYFIVNTGFFSVRLLLSLVFINLTSPVGMHLVARAAYRNGAYMYRKNDAHTHASILLSSNEQNSTEALQLRAKKREEHRKKWYQND
What are the official names of this protein?
Putative antiporter subunit mnhG2, Mrp complex subunit G2, Putative NADH-ubiquinone oxidoreductase subunit mnhF2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SP5AD_BACSU
Sequence: MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEMHCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIPFLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDTATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFKDLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGGSGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERAGGAS
What are the official names of this protein?
Stage V sporulation protein AD.
Protein: AMPA_KORVE
Sequence: MKIHLSTLDPAQLETDALIVLAIDGGDKDNNKPQLQAKSDAFAKAAADLIASKEITGKLLEIATLHKPEGVKAKRLIVVGVGKAKSFTSYELRKAAGAAVRALKKSVKSAAIVAPENWGGAADPSTTSTLMFERGGLPEAVKAIAEGAVVANPDYNYYHSDRKTYELDELTILVPANGHANDLEAAMKEGHVIGESQNFTRDLVNEPGNRMTPTILGQRAKKMAEEVGIQCDVYSTDFLHEKKMGAFWSVSQGSEEPPALIVMKYEPAGAPQSPVLGLVGKGITFDTGGISIKPADGMEKMKYDMAGGAAMIGAMRAIALLKPNVRVIGVVCAAENMPSGKAQKPGDVQIAMSGKSIEIINTDAEGRLVLADGLHYAKQLGATHLIDAATLTGACMVALGGINAGVFANDEDYFNRFAEALKKSGEKMWRLPIDDDYKELIKSPIADIKNTGGRYGGAITAAMFLKEFVGETPWIHLDIAGVAWQEEAVPFLAKGPSGIAVRSIIELVQSFG
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_PROMT
Sequence: MPTIQQLIRTERKTLKTKTKSPALRGCPERRGVCTRVYTSTPKKPNSALRKVARVRLTSGFEVTAYIGGIGHNLQEHSVVLLRGGRVKDLPGVRYHIVRGSLDTAGVKDRRQSRSKYGAKSPKE
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: YD521_YEAST
Sequence: MKGSKSHLVFTLLQVSQLNVFLFFLGFLLPLFLGLFVSLRSLALALSSGWFIMDLILFRTFPEAELYPAVIGKPSGLGLTEAFEFISIFFPDVQQTERNIKYNWERCFNGE
What are the official names of this protein?
Putative uncharacterized protein YDR521W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RIMM_COLP3
Sequence: MSTEEKKIILGKVGAVYGIKGWLKIHSFTDETEAILDYFPWSLKLGNNTQTVEITDWRKHNKVLIVKVAGIDDRDEAQALVGSEILTNEAALPELSEDDFYWRDLIGMSVVTNKGYDLGVVTDMMETGANDVLVVKANLKDGFSKKERLIPYLFEQVIESVSIENKQICVDWDPGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS22_MYCVP
Sequence: MTDIPTLGVEEEFLLVHPGSGAPVALNREVAARAADMDVELQLELTSCQVETATAVVDDTAHLREQLLHLRRTASAAAEHAGARLLAVGLPPTLPHEFPVTDTPRYRDIGERYGMIAHEQGICGCHVHVAVPDRDAAIAVSNRLRPWLPLLLALTANSAIYRNADTGHASWRSVLWARWPSAGPPPHFDSADEYDAAVQMLSHTGVIRDDGMVYWDVRPSANFPTVEVRVADVPATVDETVLFAALVRGCVMTALEDERHGDPVLPLAPYALKAAYWKAARNGVDGDGVDLENHVPAPVSDLLGYLTERTRPALEAAGDHELVTAGLARVTDLGNGATRQRRAWRRNHDVDDVLAEAAAATLEDG
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2-2, Gamma-glutamylcysteine synthetase 2-2, GCS 2-2, Gamma-GCS 2-2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: TSSP_HUMAN
Sequence: MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVGWLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLECRAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDGQTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRSTEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQAVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPERPSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV
What is the function of this protein?
Protease that may play a role in T-cell development.
What are the official names of this protein?
Thymus-specific serine protease, Serine protease 16.
What is the protein family that this protein belongs to?
Belongs to the peptidase S28 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal.
Protein: SYK_JANMA
Sequence: MTTHNDDAAAALPQDENKIIAERRAKLSALREQGIAFPNDFRPQHKAADLHEKYDGKTREELEAEPVTVTLAGRMMLKREAGKKAAFATLQDASGAKADGRIQIYATLDLTGEAAMAALHHYDLGDILGVVGTLFKTKTDELTIKVTELRLLTKSLRPLPDKFHGLADQETKYRQRYVDLIMNEDTRRTFKARTAAISSIRRFMAENDFMEVETPMLHTIPGGAAAKPFVTHHNALDMEMFLRIAPELYLKRLVVGGFDRVFEINRNFRNEGVSIRHNPEFTMMEFYAAYTDYKWLMDFTEAVIRQAAIDAHGTATLTYGGRELDLAKPFHRLTIVGAINKYAPQYTNEQLHDAEFIKAELKKFGVKPHAHSGLGALQLALFEETAEAQLWEPTYIIDYPVEVSPLARASDTVAGITERFELFMVGREIANGFSELNDAEDQAARFQAQVAAKDAGDEEAMYYDADYIRALEYGMPPTGGCGIGIDRLMMIITDSPNIRDVLLFPHLRRED
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_MYCAP
Sequence: MNNQSAKAVVKIQRISPRKARLVADLFRGKDVKVALGILNNTNKKASQLFIKLLNSAIANATNNHGMDASKLFVKEVLVNEGPTLKRYQPRSQGRAYSIFKRTSNLSITLEERV
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RS19_METB6
Sequence: MAAPKKTQKRMPRRREEFTYRGYKIDELKAMGLSELIPLMPARARRKFNRGLNRGEETLLEKIRGGDEKIRTHLREMIVMPEMIGKSIEIYNGKEFLKVEFQPESVFHYLGEFALTRKRVTHGSAGIGATRGSKYVPLK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: DAPF_EDWI9
Sequence: MQFAKMHGLGNDFMVVDAVTQNVYFSPELIRRLADRHTGVGFDQLLVVEPPYDPDLDFHYRIFNADGSEVAQCGNGARCFARFVRIKGLTNRRDIRVSTQNSRMTLHVGEDDRVTVNMGEPQFEPGRIPFKAAKAEKTYILRVAQQTVLCGAVSMGNPHCVLQVEDISRAQVELLGPSLESHERFPERVNVGFMQVVERSHIRLRVYERGAGETQACGSGACAAVAVGIQQGLLDEQVQVDLPGGTLHIRWPGPGTPLLMTGPAAHVYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1442_THEMA
Sequence: MNNLKLDIVEQDDKAIVRVQGDIDAYNSSELKEQLRNFISTTSKKKIVLDLSSVSYMDSAGLGTLVVILKDAKINGKEFILSSLKESISRILKLTHLDKIFKITDTVEEA
What is the function of this protein?
In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts an anti-sigma factor and thus releases a sigma factor from inhibition.
What are the official names of this protein?
Putative anti-sigma factor antagonist TM_1442.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor antagonist family.
Protein: PETN_ACAM1
Sequence: MDILTLGWVSVLTLFTYSIAMVVWGRHGM
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RS11_CORGL
Sequence: MPPKARTNARRTGRRVVKKNVANGNAYIKSTFNNTIVSITDTNGAVISWASSGHVGFKGSRKSTPFAAQMAAENAARKAMDHGMKKVDVFVKGPGSGRETAIRSLQAAGLEIGSISDVTPQPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: Y1615_METJA
Sequence: MIDKSSEIARFSGKGILITPKTLEKPLLKWEKLEIILYKDKIVFEFVDKTIEVGVEDIEDVGAELPKKVIDIAKSTLEDITYHSSIIIKSKEFGNVMVGFAPETSIYGKAPIDNFLRKLFYILLNKKEVKILYNAGENSENTKWENGFLTFIKKRIKDGLVTKIEYRLVVEILDNEDSKIYDIFSNIKDVEIEEKDVDGEIEPVLKILQVKDGKDIISYLYTKDKKVRLFILRYMVILLDYKYIGILRYLQETVE
What are the official names of this protein?
Uncharacterized protein MJ1615.
Protein: UBID_METCA
Sequence: MSRNGAKYRDLRDFIARLEAEGELRRIGASVDPNLEITEICDRTLKSEGPALLFEHPKGSAVPLLGNLFGTPRRVALGMGEVSVGALRQVGVLLASLKEPEPPKGMRDAFEKVPLYRQVLHMAPKEVRNAPCQQEVLRGSDIDLGRYPIQTCWPGDAGPLITWPLVITRGPYKARQNLGIYRQQVIGRNKTIMRWLAHRGGALDFRDWQEARPGEPFPVAVALGADPATMLGAVTPVPDTLSEYGFAGLLRGARTEVTPCILSDLQVPASAEIVLEGFLYPGETAPEGPFGDHTGYYNEVESFPVFTIECITQRHSPIYHSTYTGRPPDEPAVLGVALNEVFVPILQKQFPEVVDFYLPPEGCSYRLAVVSMKKQYAGHAKRVMFGVWSFLRQFMYTKFVIVVDDDVDARNWKDVVWAMTTRMDPARDLTLIENTPIDYLDFASPVSGLGSKVGFDATHKWPGETNREWGRPITMDAAVRRRVDEIWDSLGIFAGSRG
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NUOC_HERAR
Sequence: MTIKLELLESALRNALGDQLQSLTLALGEITIVVNSRDYASAMRVLRDHADLRFEELIDLCGVDYSTYGDGAWDGQRFAVVSHLLSITHNWRVRVRVFASDDEMPVVASMTEIWPAANWYEREAFDFFGILFEGHNDLRRILTDYGFIGHPFRKDFPVSGYVEMRYDPEQKRVIYQPVTIDPRENVPRVIREEQYGMK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LSM6_VANPO
Sequence: MSAAQSGTTSVSTQFLANIIGKPVSVKLYSGMMYKGKLESIDGFMNVALSNTSEHFESNAHMLKRYENDVFLRGTQVMYISEA
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates.  Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6. U5 tri-snRNP, and free U6 snRNP).  It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm6.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AHL17_ARATH
Sequence: MKGEYREQKSNEMFSKLPHHQQQQQQQQQQHSLTSHFHLSSTVTPTVDDSSIEVVRRPRGRPPGSKNKPKPPVFVTRDTDPPMSPYILEVPSGNDVVEAINRFCRRKSIGVCVLSGSGSVANVTLRQPSPAALGSTITFHGKFDLLSVSATFLPPPPRTSLSPPVSNFFTVSLAGPQGQIIGGFVAGPLISAGTVYVIAASFNNPSYHRLPAEEEQKHSAGTGEREGQSPPVSGGGEESGQMAGSGGESCGVSMYSCHMGGSDVIWAPTARAPPPY
What is the function of this protein?
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
What are the official names of this protein?
AT-hook motif nuclear-localized protein 17.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBY_PROM5
Sequence: MLRTLVVFAPIIAALAWVIFNIQKPAREQFNRDFLGKKD
What is the function of this protein?
Manganese-binding polypeptide with L-arginine metabolizing enzyme activity.  Component of the core of photosystem II.
What are the official names of this protein?
Photosystem II protein Y.
What is the protein family that this protein belongs to?
Belongs to the PsbY family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: ZRK15_ARATH
Sequence: MEWWKKKSLRAIIKRERLVRGHERGGTLLEEIIKSCNGKANPIKIFSADQILEATDTFSESNRVSELFDEIPYDWYYSGKNNNHHHHHKLLLIKKWRYRFSEHNGGNFCRDIAISSIVSGHKNFMQLVGCCLESEHPVLVYRASKKPTSLDLKMVVSWRQRLKIAEEIATALAYLHTAFPRPFVYRILRLEDILLDDEDGVAKLCNFSYCVSIPQGETFVKLGNGCIGGDYDYMDDNYLINGIVSEKTDAFGFGIFMQKLLMGEERFHELCYDRSDLTTFENRRKFAKCIDEIVDSNMLEKIGDVTEEERCRMEAFIVLSERCIGLRGEVPKMVEVAKELKRFLRDSSSSCGETSL
What are the official names of this protein?
Non-functional pseudokinase ZRK15.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. ZRK subfamily.
Protein: TFR1_HORSE
Sequence: MDQARSAFSNLFGGAPLSYTRFSLARQVDGDNSHVEMKLAVDEEENVDNNVRSNHASLTKPKRFNGSFCYAVIAVIIFFLIGFMIGYLGYCKRVEPKSECGRSGDSKEIEGTEPPETEEYFPETPSRLLWTDLRTMLSERLTATEFTNTIKRLNGNSYVPREAGSQKDESLAFFIENQFREFKLNKVWRDEHFVKIQVKGSNAQSSVTVVNGSGDMISLVENPTGYVAYSKATTVTGKLVHANFGTKEDYEALSYPVNGSLVIVRAGEITFAQKVANAESLNAVGVLIYMDQAKFPIVNANLPVFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPNIPVQTISRAAAEALFANMKGDCPSSWKTDSSCRLEFPGDKNVKLTVNNELKEIRIFNVFGVIKGFEEPDRYVVIGAQRDAWGPGAAKSSVGTALLLELARIFSDMVSKGGFKPSRSIVFASWGAGDFGAIGATEWLEGYLSSLHLKAFTYINLDKAVLGAKNFKVSASPLLYSLIEKTMQEVKHPVTGLSLYRDSNWINKVEKLSFDNAAFPFLAYSGIPALSFCFCEDTEYPYLGTTMDTYEVLSQNVPELSRLTRAAAEVAGQLLIKLSYDVELNLNYDMYNDKILSFVKDMNQFRADIKEMGLNLQWLYSARGDFFRATSRLTTDYKNAERANRVVMREINDRIMKVEYHFLSPYVSPRESPFRHIFWGSGSHTLSALLEHLKLRQKNSGAFNETLLRNQLALATWTIQGAANALSGDIWDIDNEF
What is the function of this protein?
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity).  Endosomal acidification leads to iron release.  The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.  Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).  Positively regulates T and B cell proliferation through iron uptake (By similarity).  Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity).  When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity).  When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
What are the official names of this protein?
Transferrin receptor protein 1, TR, TfR, TfR1, Trfr.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Melanosome.
Protein: MPTA_METTP
Sequence: MERLPDVQACHPAYPINLTRVGVTGVKKLVKVERSGERPIVLISNFEVFVDLPSSRKGANLSRNTEAIDEVLEEEISRPVYEIEELCGKIALRLLERHEYATRAEVKMKSEYIVKRQTPATRVNCQEVVDIFAEAMATSGPDPHVKKIVGAEVIGTTACPCAQEIVREQMRRDLLNLGLSEDAIEGFLKKVPVATHNQRGRGSISIEVRDRKCVPIDRIIRIIEESMSSKVYGLLKRPDEALVVSRAHMNPMFVEDCVREMAQRVVATFVELPDDAVVTLKQINEESIHRHNAFAERVAKMGELRAELAAIHEMQPCGASQM
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RLMH_CAMLR
Sequence: MQINLLSIQKNNNDEFSKIDEHYTKLIKKFCSFNEICVFNNKINQAQNTNSIEAKKSYTNALNPYKKGFCIALDEKGKEFTSVEFAKLLQDKNEITFFIGGAYGFEQEFIAQMHTSIALSKMTLVHKFAKTMLLEQIYRAFCINTNHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.