PharMolix/UniProtQA huggingface dataset:
Protein: MNHC1_STAAS
Sequence: MEIIMIFVSGILTAISVYLVLSKSLIRIVMGTTLLTHAANLFLITMGGLKHGTVPIYEANVKSYVDPIPQALILTAIVIAFATTAFFLVLAFRTYKELGTDNVESMKGVPEDD
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit C1, Mnh complex subunit C1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SPEE_SYNJB
Sequence: MSSPRSFFWVQEYFTPWDYTARAVTRILAYRKTPFQEMLIAETGAFGKGLMLDGHWQSTTVDEFLYHEALVHPAMVQVVQAGGIPRRVLVLGGAEGATLREVLRWRSVEQVVMVDIDGEVVAACREHLPEMHQGSFEDPRVEVVIADALDFLQETGPIWDVILSDLSDPIESGPAYRLFTQEFFRQIRSKLQPDGAFTIQAGPTGPVELHQHTRIVRTLKTVFAAVQPYAIYAPTYGGPLGFALAAQDPISPRPEPEQIDQILSQQLDPERGALQFIDGITLLGLYQVPAHLRRAIAAETVVYTLDNPPRIE
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBF4_YEAST
Sequence: MVSPTKMIIRSPLKETDTNLKHNNGIAASTTAAGHLNVFSNDNNCNNNNTTESFPKKRSLERLELQQQQHLHEKKRARIERARSIEGAVQVSKGTGLKNVEPRVTPKELLEWQTNWKKIMKRDSRIYFDITDDVEMNTYNKSKMDKRRDLLKRGFLTLGAQITQFFDTTVTIVITRRSVENIYLLKDTDILSRAKKNYMKVWSYEKAARFLKNLDVDLDHLSKTKSASLAAPTLSNLLHNEKLYGPTDRDPRTKRDDIHYFKYPHVYLYDLWQTWAPIITLEWKPQELTNLDELPYPILKIGSFGRCPFIGDRNYDESSYKRVVKRYSRDKANKKYALQLRALFQYHADTLLNTSSVNDQTKNLIFIPHTCNDSTKSFKKWMQEKAKNFEKTELKKTDDSAVQDVRNEHADQTDEKNSILLNETETKEPPLKEEKENKQSIAEESNKYPQRKELAATPKLNHPVLATFARQETEEVPDDLCTLKTKSRQAFEIKASGAHQSNDVATSFGNGLGPTRASVMSKNMKSLSRLMVDRKLGVKQTNGNNKNYTATIATTAETSKENRHRLDFNALKKDEAPSKETGKDSAVHLETNRKPQNFPKVATKSVSADSKVHNDIKITTTESPTASKKSTSTNVTLHFNAQTAQTAQPVKKETVKNSGYCENCRVKYESLEQHIVSEKHLSFAENDLNFEAIDSLIENLRFQI
What is the function of this protein?
Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation.  DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex.  DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication.  DDK has also postreplicative functions in meiosis.  DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination.  Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation.  Inhibits CDC5 activity during mitosis through direct binding to its PBD.
What are the official names of this protein?
DDK kinase regulatory subunit DBF4, Dumbbell forming protein 4.
Protein: TNPX_ECOLI
Sequence: MELNITSKSNPFGDTTAENDKKMLSNAFIETADFRTLIETDDRTIVVGRRGTGKSALFIQLNEHWKKDKKILILSFSPDDSQIIGFRSMLKPFTGSFNLARAATRLLWRYAMLMEIASYISSHYKLSSQISSETLLNEHLKKWNSAQGDILRKCRLVAKEYLDENNPEESIGDLQFNLNISEIENNIVSLLERSDRKVVILMDKLDEAYEPDNIGIGIIAGLAYASIELNQKAKCIRPIIFLRDNIFRSLSKEDPDYSRNIEGQVIRLHWDWAQLLMLSAKRMKVAFKLDIEKDQRVWDRCTADDLKGRNGFKRCLQFTLYRPRDLLSLLNEAFFSAFRENRETIINTDLEYAAKSISMARLEDLWKEYQKIFPSIQVITSAFRSIEPELTVYTCLKKIEASFELIEENGDPKITSEIQLLKASGILQSLYSVGFVGIRDKNTSSYSFCHDGRTPDKGFESNEKLLIHPCYWLGLNLNRNALAPEEAEEINDEYDINIISDNSAIRNKTIGQITTHLDQIPIGNEGATEFEQWCLDALRIVFASHLTDIKSHPNGNAVQRRDIIGTNGGKSDFWKRVLEDYKTRQVVFDAKNFEELGPSEYRQLQSYLTGPYGKLGFIINRDESEVLKSGKDLDWTKEMYQSHNSLIIKLPAKYISKLLQKLRNPEKHDAIDRQMGKLLTLYETSYMAIKSTQKKRRK
What are the official names of this protein?
Putative transposon gamma-delta 80.3 kDa protein, Transposon Tn1000 protein TnpX.
Protein: UBP33_BOVIN
Sequence: MSSFRSHCPHLDSVGEITKEDLIQKSHGSCQDCKVRGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVKPLHQIQENGVQDFKIPSNTTLKTPLVAVFDDLDIEVEEEDELKARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTIMTEETMEEDKSQSDVDFQSCESCSSSDKAENENGSRSFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVHSEGELDKDRDSVSETADLNNQETVKVQIHSRASEYITDVHLNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLPPTHKKVQSALSPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPVQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQEEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVILRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDAVQAEEKIEVETRSL
What is the function of this protein?
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling.  Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate.  Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling.  Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1.  Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2).  Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2.  Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2.  This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins.  Deubiquitinates DIO2, thereby regulating thyroid hormone regulation.  Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 33, Deubiquitinating enzyme 33, Ubiquitin thioesterase 33, Ubiquitin-specific-processing protease 33.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP20/USP33 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (By similarity).
Protein: Y008_TREPA
Sequence: MTMGFVEYARKIIDGEPRKDDMREALAESFDLFTRDAHWRIAPYLRLKTHEIVPNHVLVYTDTYVLGKFTLPVTDQVLPEGYWALTAKE
What are the official names of this protein?
Uncharacterized protein TP_0008.
Protein: RLR28_PLAVT
Sequence: MHVSRIIAHIALATAITATTVSPTDAAWGWTVKSTDEVKADKRDLVASRGLRGLIGQASPNEVSPANVPVSGIPLLGDKQPSGYPMLPADSPSTGSSLLNDDLLQENPVPPANGLVHGVPLLSSNQPLQTPMLSGNGPITGYRFFSGNESPMLPANSPITGLPLLSGNIPSTFEGEQISNGDEYQQNVDEDKGQNFGHSVSGPPTTTLTGPHTKSGIPPFENLVAPAKGSMPNTRRNGYQFFE
What is the function of this protein?
Effector that significantly enhances susceptibilities of grapevine and tobacco to pathogens (PubMed:27242731).  Acts as a broad suppressor of cell death to interrupt plant immunity.  Completely inhibits cell death induced by cell death-inducing proteins, including the PAMP elicitor INF1 from P. infestans (PubMed:27242731).  Reduces the transcriptional levels of the defense-related genes and impairs the H(2)O(2) accumulation in N. benthamiana (PubMed:27242731).
What are the official names of this protein?
Secreted RxLR effector protein 28.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus.
Protein: TRPC_SACEN
Sequence: MSVLESIIDGVREDLAVRESTIPFDEIKQRSAAAPPPRDVMAALHAPGVGVIAEVKRRSPSKGELADIAEPAELAADYAAAGARVISVLTEQRRFGGSLADFDAVRAKVSAPLLRKDFIVSPYQVHEARAHGADMVLLIVAALEQVALEALLDRVESLGMTALVEVHTAEEADRALEAGAKVIGINARNLHTLEVDRDVFGRIAPGLPVEVLKVAESGVRGPSDLMAYAGSGADAVLVGEGLVTSDNPRTAVTQLVTAGSHPACPRPSR
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: RECF_ACTPJ
Sequence: MPLSRLIINNFRNLQSLDLELSPNFNFIVGHNGSGKTSLLEAIFYLGHGRSFKSHISNRIIHYQAEDFVLHARIDEGQHQWSVGIQKKRSGDTLLKINGEDGNKISDLAHLLPMQVITPEGLTLLNGGPTFRRAFLDWGLFHQYTEFYSCWANLKRLLKQRNAALHQVRSYAELKPWDIELAKLAEIVSQMRASYAEALRPEIEKTCQFFLPELEIGVSFHQGWEKGTDYAEILAQGFERDKAMGYTMIGPQKADFRFRANGLPVEDVLSRGQLKLLMCALRLAQGEYLVAQKERQCLFLIDDFASELDPIKRELLAHRLRESGSQVFVTAITKDQLNQMQWQESEQDSLFQVQQGMLTK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF1_BART1
Sequence: MFIASAYAQNTETSIEHIKKVAEHANRVFPPFDFVHFSSHFFWLAISFGFFYLFISRVIAPRIGGVIETRRDRIASDLDQAMRMKQEADTVVETYERELAEARLKAHTIAQAAGEELKQKAELERKEIEERLEKKLADAEKQIAKIRDKAMQNVGSIAEEVTLGIVKKLIDVDINKETVRSVIKTANY
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b 1, ATP synthase F(0) sector subunit b 1, ATPase subunit I 1, F-type ATPase subunit b 1, F-ATPase subunit b 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RM35_DROME
Sequence: MLRTFVTSALRSVCRQSPAASSLVPLVQRTQRATLMTLSRPCLLPTPSLASPAHHQLLQLPGVLAATGTPSNTRNVTKFSLVKGKRKTVKAVLKRFKRLDWGAWIRTHSGRQKKLFKKSAALRRRLKQHVFTNATQSWLLDKMVTSYWRRPKHFINDPYKPYHSRNEYYATQSKTFKV
What are the official names of this protein?
39S ribosomal protein L35, mitochondrial, L35mt, MRP-L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DGUSI_AQUCR
Sequence: MSSAKLGSASEDVSRRDANYHPTVWGDFFLTHSSNFLENNDSILEKHEELKQEVRNLLVVETSDLPSKIQLTDEIIRLGVGYHFETEIKAQLEKLHDHQLHLNFDLLTTYVWFRLLRGHGFSISSDVFKRFKNTKGEFETEDAWTLWCLYEATHLRVDGEDILEEAIQFSRKKLEALLPELSFPLNECVRDALHIPYHRNVQRLAARQYIPQYDAEPTKIESLSLFAKIDFNMLQALHQSVLREASRWWKEFDFPSKLPYARDRIAEGYYWMMGAHFEPKFSLSRKFLNRIIGITPLIDDTYDVYGTLEEVTLFTEAVERWDIEAVKDIPKYMQVIHTGMLGIFEDFKDNLINARGKDYCIDYAIEVFKEIVRSYQREAEYFHTGYVPSYDEYMENSIISGGYKMFIILMLIGRGEFELKETLDWASTIPEMVKASSLIARYIDDLQTYKAEEERGETVSAVRCYMREFGVSEEQACKKMREMIEIEWKRLNKTTLEADEISSSVVIPSLNFTRVLEVMYDKGDGYSDSQGVTKDRIAALLRHAIEI
What are the official names of this protein?
Inactive delta-guaiene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: NUOK_PECAS
Sequence: MIPLQHGLILAAILFVLGLTGLLIRRNLLFMLISLEIMINAAALAFVVAGSYWQQPDGQVMYILAITLAAAEASIGLALLLQMYRRRQTLNIDTVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MUTH_ECO5E
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_SHESH
Sequence: MAVFKAITTEQVEILTAGLYAGVDEVGRGPLVGNVVTAAVILDPTKPITGLNDSKKLSEKKREALFTEIHEKALAISIGYASPEEIDELNILHATMLAMQRAVAGLDMAPTSVLVDGNRTPDFSHGEDTDRNIESHAIIKGDGLVAGISAASIVAKVIRDREMDLLDMEHPQYGFAKHKGYPTKAHFEALALHGVLPEHRKSFRPVKERLAKN
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEAH_ECOL6
Sequence: MTWFIDRRLNGKNKSMVNRQRFLRRYKAQIKQSISEAINKRSVTDVDSGESVSIPTEDISEPMFHQGRGGLRHRVHPGNDHFVQNDRIERPQGGGGGSGSGQGQASQDGEGQDEFVFQISKDEYLDLLFEDLALPNLKQNQQRQLTEYKTHRAGYTANGVPANISVVRSLQNSLARRTAMTAGKRRELHALEENLAIISNSEPAQLLEEERLRKEIAELRAKIERVPFIDTFDLRYKNYEKRPDPSSQAVMFCLMDVSGSMDQSTKDMAKRFYILLYLFLSRTYKNVEVVYIRHHTQAKEVDEHEFFYSQETGGTIVSSALKLMDEVVKERYNPAQWNIYAAQASDGDNWADDSPLCHEILAKKILPVVRYYSYIEITRRAHQTLWREYEHLQSTFDNFAMQHIRDQDDIYPVFRELFHKQNATAKD
What are the official names of this protein?
UPF0229 protein YeaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: DTD_ECO7I
Sequence: MIALIQRVTRASVTVEGEVTGEIGAGLLVLLGVEKDDDEQKANRLCERVLGYRIFSDVEGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSKGASPDRAEALYDYFVERCRQQEMNTQTGRFAADMQVSLVNDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_HERAR
Sequence: MMQVRMQAEPQQLTLALSKGRIFEETLPLLEAAGIKVTEDPETSRKLILQTSDANVRVIIVRASDVPTYVQYGAADFGVAGKDVLLEHGGEGLYQPIDLHIAKCRMSVAVKDGFDYASAVQQGARLRVVTKYVQTAREHFAAKGVHVDLIKLYGSMELGPLVGLADAIVDLVSTGSTLRANQLVEVEHIMEISSRLVVNKAALKLKRERLQPILEAFEKASKRSS
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTEA_BACSU
Sequence: MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGELSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIPFERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDVEKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHERYEEELDEEGIMTTFGDLHAD
What are the official names of this protein?
Uncharacterized protein YteA, ORFQ.
Protein: YCB5_SCHPO
Sequence: MRINFVLLITLILPWFVSGDSSEEAVDAPLDVKDDTGNKDYYKDSTGAYHFDKLIVTPLEYRDGESWKQSVIYCDLIFAKENKEEKGSFVKAQLKEDAEHPFIYRLLKLQTPLETYRGFIDGKNTEILDEIKSINLFEDFLSESLVPEISPSVNIPIDETALYCFIGIQETEPIRIPWPVLTVEFYGDAPPPESYFRTIKSTLLAISMFLGFITLTWLLRCIKSQSGVQPAQISLAFWVFIFVFTHSYQVYSMVAIGRGSFSTWYVVSFLFSLVFEEGLEQSAYTSFLLVLCFGLGITKPALVKYYVYLAFVAFVQGLFVTFAPLSYPVMSFYGVRGILLKLIWNIYTFVYYGLPFFAVYRLYKQAGESRKLGFEAKYSLLRTCYIALAAVTVSNCLFLGVVRPLLGSQLSLGFQLITSCITFVDFLVFAFLFDCSKFVFLKYQPIPFEWYALESMESLNLEPAPDRKV
What are the official names of this protein?
Uncharacterized membrane protein C61.05.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NSUN4_XENLA
Sequence: MSACRGFLLRRINDSCLTFRRHKFKKKWATTLPKIPCSRLALQYFDINYSMQFGDLWPSIRISLLTEQKYGALVNNFSHKETVLNNLSALKAKDFISEAQSVISLLQTQNNVDTSEKMVFTEVPLNLVGEKNDAEQTQATNLLSSLSNSKLTCFTFSRGDISRFPQSRSDCFGLLEYYLMDAASLLPVLALDIQHGHSVLDLCAAPGGKTLALLQTENCQYLAANDLSTSRSSRLHRVLHSYVPRDQRAEHKVRITSWDGRLWGDLEASTYDRVLVDVPCTTDRHSLLEEENNIFHRIRTKQRQMLPLLQTELLVSGLRAVRPGGEVVYSTCSLSQLQNECVVQRAIELAATDHGVLVKPQDLSCFREVFKNTFNFFQDCRVGELVVPHLTANFGPMFFCKLLRIK
What is the function of this protein?
Involved in mitochondrial ribosome large subunit biogenesis.
What are the official names of this protein?
5-methylcytosine rRNA methyltransferase NSUN4, 5-methylcytosine tRNA methyltransferase NSUN4, NOL1/NOP2/Sun domain family member 4.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DPCKG_SULIM
Sequence: MEIRDNNKVNLCFAFDNLRKELSRPYGILFTNNKVFLDFVSKSIQQGFKVITVGDYVSRVLEENGIIPFLEVIDGKTKRSIPQHRAIVKNKEYRVTNEAGKIRFEIFEIIENILKDRDGGVVFVNGEEDLLVIPVILSANNGDIVIYGQPNAGAVVIIVNEMIKWRVRDILEKAVVEEC
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
What are the official names of this protein?
GTP-dependent dephospho-CoA kinase, Dephospho-coenzyme A kinase, DPCK.
What is the protein family that this protein belongs to?
Belongs to the GTP-dependent DPCK family.
Protein: RS18_STAAE
Sequence: MAGGPRRGGRRRKKVCYFTANGITHIDYKDTELLKRFISERGKILPRRVTGTSAKYQRMLTTAIKRSRHMALLPYVKEEQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: YQGD_SCHPO
Sequence: MPLNVTVEEETLQIVEEEPQQEITNTILEEDFNLLDNSFQTDISSTSSQNDSKFTCLLVRHAESEHNVRGIRAGARIDSELTVHGYNQAKKLAKSIRNLDIVCVYSSPQKRAKRTAEEITKVANCPLYISDFLMEKDLGSLEGTSFRYTANYRPREPPMKVTNLESRDSLLTRARGFTDILFNEAIGFEGESGKTIVVVSHGIFLPFLLRAILARARTPLPSMIIPWNNASYCLITIDLGGNSIVKMNCNSHLRGIKRTRKLGSSTYDSKQKPITEFCSKLN
What are the official names of this protein?
Probable phosphatase C1620.13.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSHR_ATEPA
Sequence: MPMQGAQKRLLGSLNSTPTATPNLGLAANHTGAPCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYCFICCLALSDLLVSSSNMLETAVILLLEAGALATRASVVQQLQNTIDVLTCSSMLCSLCFLGAIAVDRHVSIFYALRYHSIMTLARARRAIAAIWVASVLSSTLFIAYCDHAXVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGITRLHQRQPPAHQGFGFRGAATLTILLGIFFLCWGPFFLHLTLVVLCPQHLTCSCIFKNFKVFLTLIICSTIIDPLIYAFRSQELRRTLKELLLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UVRB_AROAE
Sequence: MTSSTDSVPVITFADSPFRLHQPFPPAGDQPAAIELLTEGIGDGLMYQTLLGVTGSGKTYTMANVIARCGRPALVLAPNKTLAAQLYAEFREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSCIYGIGDPVDYHAMILHLREGERIAHRDLVQRLVAMQYTRSDIDFRRGTFRVRGDVIDVFPAENAELAVRIEMFDDEVEHLTLFDPLTGHLKQKLVRFTVYPSSHYVTPRATVLKAIEAIKDELRDRSAWFQTSGKLVEAQRIEQRTRFDLEMLNEMGFCKGIENYSRHLSGRGQGEPPPTLIDYLPSDALLFVDESHVSIPQVGGMYKGDRSRKENLVGYGFRLPSALDNRPLKFEEFERLMPQTIFVSATPSTYEAEHQGQVVEQVVRPTGLIDPAIDVRPATTQVDDLLSEAKRRIAVGERVLVTTLTKRMAEDLTDYLAENGIRVRYLHSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARHINGRAILYADVVTRSMRAAIDETERRRVKQIAFNQANGIVPKTVSKRIKDIIDGVYGGDVERDGRSVAEPPPEYFSMNEKTVAKSIRKLEKEMQEHARNLEFEKAAAARDELFRLRQRTFGADQHGTP
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIB_STAAU
Sequence: MKNKLIAKSLLTIAAIGITTTTIASTADASEGYGPREKKPVSINHNIVEYNDGTFKYQSRPKFNSTPKYIKFKHDYNILEFNDGTFEYGARPQFNKPAAKTDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVR
What is the function of this protein?
Extracellular fibrinogen-binding protein that plays an important role in virulence (PubMed:7934883).  By interacting with the alpha chain of fibrinogen and its derivative fibrin, enhances a non-functional interaction between fibrinogen and platelets and is responsible for repression of fibrinogen-dependent platelet aggregation.  In addition, assembles a fibrinogen protective shield around the bacteria which results in impaired phagocytic clearance by the host.  Mechanistically, interacts with host complement C3b deposited on the surface of the bacterium via its C-terminal and then recruits fibrinogen via its N-terminal (By similarity).
What are the official names of this protein?
Fibrinogen-binding protein.
What are the subcellular locations of this protein?
Secreted.
Protein: RL36_RICPR
Sequence: MKVVSSLKSLKKRDKDCQIVKRRGKIFVINKKNKRFRAKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.