PharMolix/UniProtQA huggingface dataset:
Protein: RL32_STRS2
Sequence: MAVPARRTSKAKKNKRRTHYKVAAPTVKFDETTGDYSRSHRVSLKGYYKGRKIAKAASAE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RL19_STRLI
Sequence: MSHLLDSVDAASLRSDVPAFRPGDTVNVHVRVIEGNRSRVQQFKGVVIRRQGAGVRETFTVRKVSFSVGVERTFPVHTPIVEKIELVTRGDVRRAKLYYLRELRGKAAKIKEKRDS
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: HUTU_STAAW
Sequence: MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIHQAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISFHHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPA_METTH
Sequence: MHELSMADAIVRTVIDAAEKNDAVEVLEVTVEIGQLTLLNPEQIEFMLDVLSEGTILEGARFNLEVVPVEIECECGYEGVVEADELDHFAPVIKCPACGGHEFHVRAGRECNVKNIKIEKKD
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: AROQ_FRATN
Sequence: MDVLVINGPNLNLLGTRQPQFYGHKTLADINNDLLKIAKENNINIDFYQSNHEGQIIDKIQQTAAKIIIINPAAFTHTSVAIRDAFLAINKPFIEIHLSNIYNREEFRTKSFLSDIAYGCIFGFGPNGYTLALIEAINYINMKGE
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: NEF_HV1ND
Sequence: MGGKWSKSSLVGWPAIRERIRKTDPAADGVGAVSRDLEKHGAITSSNTASTNDTCAWLEAQEESEEVGFPVRPQVPLRPMTYKEAVDLSHFLKEKGGLEGLIWSKKRQEILDLWVYNTQGIFPDWQNYTPGPGIRYPLTFGWCFQLVPVDPQEVEEATEREDNCLLHPMCQQGMEDPERQVLMWRFNSRLALEHKARELHPEFYKDC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: UNG_NEIG2
Sequence: MDTWHDALGGEKQQPYFQEILNAVRQERLSGQIIYPPEADVFNAFRLTAFDRVKVVILGQDPYHGVGQAHGLAFSVRQGVRIPPSLLNIYKELETDIEGFSIPAHGCLTAWAEQGILLLNTVLTVRAGQAHSHALLGWERFTDTVIRQLATHRKHLVFMLWGGYAQQKGRLIDSQNHLILTAPHPSPLSAYRGFFGCRHFSQANSYLSQHGIEPINWKL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAM9C_HUMAN
Sequence: MAAKDQLEVQVMAAQEMELAGKDPVSHEHEERKPVTETKEGDVTDEHGERGSFAETDEHTGVDTKELEDIAADIKEHLAAKRKRIEKIAKACSEIKNRIKNVLRTTQLKRQKRDYRISLKLPNVLEEFITDEQKDEEGDGEKEEQIKIFQEQQKRWQQDGKGTERD
What are the official names of this protein?
Protein FAM9C.
What is the protein family that this protein belongs to?
Belongs to the FAM9 family.
Protein: FDHD_YERPY
Sequence: MSQIKPSRLSSSAEIRGARQLDVLQRHKLAEPQQDWLAEEVPVALVYNGISHVVMMATPKDLAAFALGFSLSEGIISSPQDIYAIEITPGCNGIEVNIELSSRRFAGLKERRRAMAGRTGCGVCGIEQLDDIFRPITPLPFTQAFNLEHLDTALAQLKQVQPVGQLTGCTHAAAWINPEGELLGGCEDVGRHVALDKLLGIRAKQPWQQGAVLVSSRASYEMVQKTAMCGAEILFAVSAATTLAVEVAERCNLTLVGFSKPGRATVYTHPQRIK
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA1_VESSQ
Sequence: GSKCPFSDDTVAMVIVTRENRNRDFYTLQTLRNHDEFKKKAITRPVVFITHGFTSSATVESFVDLQTAILEXXXXKVTVSDWRVAACNRTTGLLYYVTAVSNTRLVGRYIATVTKKLVTDYNVSMADIRLIGHSLGAHVSGFAGKEVQKLKLEKYSEIIGLDPAGPSFESNDCAERLCKTDAHYVQIIHTSKKFGIEKSIGHVDFYVNQGNNQPGCGIIPLKDVCSHSRAITYMTECIKRECCLIGIPQSKSSKSISSCTRQECVCVGLKAKSYPNTGSFYVPVESTAPFCNNKGKII
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylcholine with phospholipase A1 activity (By similarity).  May act as an allergen and induce hemolytic activity (By similarity).
What are the official names of this protein?
Phospholipase A1, PLA1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: MYB82_ARATH
Sequence: MECKREEGKSYVKRGLWKPEEDMILKSYVETHGEGNWADISRRSGLKRGGKSCRLRWKNYLRPNIKRGSMSPQEQDLIIRMHKLLGNRWSLIAGRLPGRTDNEVKNYWNTHLNKKPNSRRQNAPESIVGATPFTDKPVMSTELRRSHGEGGEEESNTWMEETNHFGYDVHVGSPLPLISHYPDNTLVFDPCFSFTDFFPLL
What is the function of this protein?
Transcription activation factor positively regulating trichomes development (PubMed:24803498).  Has a function nearly equivalent to that of GL1 and can complement gl1 mutants (PubMed:24803498).
What are the official names of this protein?
Transcription factor MYB82, Myb-related protein 82, AtMYB82.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYV_THET2
Sequence: MDLPKAYDPKSVEPKWAEKWAKNPFVANPKSGKPPFVIFMPPPNVTGSLHMGHALDNSLQDALIRYKRMRGFEAVWLPGTDHAGIATQVVVERLLLKEGKTRHDLGREKFLERVWQWKEESGGTILKQLKRLGASADWSREAFTMDEKRSRAVRYAFSRYYHEGLAYRAPRLVNWCPRCETTLSDLEVETEPTPGKLYTLRYEVEGGGFIAIATVRPETVFADQAIAVHPEDERYRHLIGKRARIPLTEVWIPILADPAVEKDFGTGALKVTPAHDPLDYEIGERHGLEPVSVINLEGRMEGERVPEALRGLDRFEARRKAVELFREAGHLVKEEDYTIALATCSRCGTPIEYAIFPQWWLRMKPLAEEVLKGLRRGDIAFVPERWKKVNIDWLENVKDWNISRQLWWGHQIPAWYCEDCQAVNVPKPERYLEDPTSCEACGSPRLKRDEDVFDTWFSSALWPLSTLGWPEETEDLKAFYPGDVLVTGYDILFLWVSRMEVSGYHFMGERPFKTVLLHGLVLDEKGQKMSKSKGNVIDPLEMVERYGADALRFALTYLATGGQDIRLDLRWLEMARNFANKLYNAARFVLLSREGFQAKEDTPTLADRFMRSRLSQGVEEITALYEALDLAQAAREVYELVWSEFCDWYLEAAKPALKAGNAHTLRTLEEVLAVLLKLLHPMMPFLTSELYQALTGKEELALEAWPEPGGRDEEAERAFEALKQAVTAVRALKAEAGLPPAQEVRVYLEGETAPVGENLEVFRFLARADLLPERPAKALVKAMPRVTARMPLEGLLDVEEWRRRQEKRLKELLALAERSQRKLASPGFREKAPKEVVEAEEARLRENLEQAERIREALSQIG
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_CLOBH
Sequence: MSNISVIGTGSYVPNNIITNDFLSTIVDTSDEWIRTRTGILERRISKGENTIYMATESAKEAIKNANIEANDLDLIIVATLTPDNFMPSTACSVQKEIGAMNALCFDISAACSGFIYGLEIACSMLKNSFRNKALIIGAENLSKIVDWEDRNTCVLFGDGAGSAILSKTKEEGILEFHSGSNGLKGEHLTCGVLKANNTPNKNDSLEKNNFIKMNGKEIFRFAVGAMNETIYNIQEKTKWDLNEVKYIISHQANSRIIEYTAKKLNTEKDKFYMNLDKYGNTSAASIPIALDEMNKRGLLNKQDKIILVGFGGGLTFGGVAIVWSI
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEP_RAT
Sequence: MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
What is the function of this protein?
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:2966343).  Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:2966343).  Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity).  Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:2966343).  Involved in the degradation of the atrial natriuretic factor (ANF) (PubMed:2966343).  Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity).
What are the official names of this protein?
Neprilysin, Atriopeptidase, Enkephalinase, Neutral endopeptidase 24.11, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE.
What is the protein family that this protein belongs to?
Belongs to the peptidase M13 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: RL20_LEGPH
Sequence: MPRVKRGVTAKARHKKILDQAKGYYGARSRTYRVAKQAVIKAGQYAYRDRRQKKRQFRALWITRINAQARECGLSYSRLIDGLKKASIELDRKILADMAVHDKVAFAAIAEQAKAALAG
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RL6_DICNV
Sequence: MSRIGKQPVSIPSGVECSIKGQLLSVKGKKGQMTLDLHPFTKITSEDGFLKLNPVVEDRDHWAICGTMRALVHNMVVGVTQGFEKKLLLMGVGYRAQAQGQKLTLVLGFSHPVEYAVPQGITIETPTPTEIIVKGFDKQLVGEVAAKIRAYRPPEPYKGKGVRYAGEYVMIKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RL20_LACCB
Sequence: MPRVKGGTVTRKRRKKVLKLAKGYRGAKHLLFKAANAQVMVSYRYAFRDRRAKKRDFRRLWIARINAAARMNDISYSKLMHGLKVANVDMNRKMLADLAVSDPDGFKAVADTAKKALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PROB_SALHS
Sequence: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHIGQMLLTRADMEDRERFLNARDTLRALLDNHIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQQGLFTADPRSNPQAELIKDVYGVDDALRSIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIASGSKPGVIGDVMEGISVGTRFHAQASPLENRKRWIFGAPPAGEITVDEGATAAMLERGSSLLPKGIKSVTGNFSRGEVIRICNLQGRDIAHGVSRYNSDALRRIAGHHSQQIDAILGYEYGPVAVHRDDMITR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPPA_SULIA
Sequence: MRIIPRTMSTQHPDNAKVPEWAKSEVIEGEDEVKEAFLAYSMYGVHEVMWDAEGKDVDTHVVRKLLSNYPDYFREHILGKDVFLTYRLPNPKVEGADRKVFAETMESIPITYDLAEKFYGNGITVPVFEVILPMTTSNLEIISVARYYEKAVANEDELELYNGVKVKDLVGEIYPKVIEVIPLVEDRDSLQNIDNIVEGYYKVIKPKYMRVFLARSDPAMNYGMITAVLSVKIALSELYKLSESLNFEIYPIIGVGSLPFRGHLSPENYEKVLEEYKGVYTYTIQSAFKYDYDYDKVKSAISSINNSRIGPAKILEKYEEDVLRKITILYTERYQPIIESLANAINDVSVLLPRRRARKLHIGLFGYSRSAGKVSLPRAISFVGSLYSIGIPPELIGISSLSNLDEKEWDIFKQNYVNFKHDLQTAARFFNWESFELIKDIWKISEDTIAKIKEDIDYAESVIGIKLGDIDYDSRKHILMSSLFLLSFKEKILQESKKYLYEMALIRRSLG
What is the function of this protein?
Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 2 family.
Protein: ISPG_TROWT
Sequence: MSIDLGLPKVREVLSPRRKTRRIKLGKVFVGGDSPILVQSMTTTQTTNIDATLQQIAELTAAGCDIVRVAVPSRDDAQVLHIIAKKSQIPVIADIHFQPNYVYAAIDAGCAAVRVNPGNIRKFDDQIGKIAEKAKAAGVSIRIGVNAGSLDPRLLEKYGRPTAQALVDSAVWEAGLFEEYDFHDFKISVKHHDPVTMVKAYRLLAERGDWPLHLGVTEAGPAFQGTIKSSTAFAVLLAEGIGDTIRVSLSAPPVEEVKVGLEILRSLGLRERRLEIVSCPSCGRAQVDVYRLAEEVTKGLEKLTVPLRVAVMGCIVNGPGEAREADLGVASGNGKGQIFVRGQVIKTVPESEIVPTLLEEANRLAGEMPFSSGSPTIAIV
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: EXBB_NEIMB
Sequence: MNLKLVFESGDPVLIGVFVLMLLMSIVTWCLVVLRCIKLYRARKGNAAVKRHMRDTLSLNDAVEKVRAVDAPLSKLAQEALQSYRNYRRNEASELAQALPLNEYLVIQIRNSMAQIMRRFDYGMTALASIGATAPFIGLFGTVWGIYHALINIGQSGQMSIAAVAGPIGEALVATAAGLFVAIPAVLAYNFLNRGTKILTQDLDAMAHDLHVRLLNQKDS
What is the function of this protein?
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.  Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
What are the official names of this protein?
Biopolymer transport protein ExbB.
What is the protein family that this protein belongs to?
Belongs to the ExbB/TolQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PHAJ_RHORT
Sequence: MSADDLILHYFEDIKEGQSASLAKTISESDIYLFAGLSMDTNPAHVNEDYAQTTVFKTRIAHGMLSAGFISAVLGTRLPGPGAIYVNQSLKFKAPVRIGDTVTATVTVTGLVPEKKFVTFRTTCTVAGKVVIEGEATVMVPARG
What is the function of this protein?
Catalyzes the hydration of trans-2-enoyl-CoAs with a chain-length of 4-6 carbon atoms, forming the corresponding (3R)-3-hydroxyacyl-CoAs, which can then be utilized for the production of polyhydroxyalkanoates (PHA) polymers.  Cannot use trans-2,3-octenoyl-CoA as substrate.
What are the official names of this protein?
(R)-specific enoyl-CoA hydratase, (R)-specific trans-2,3-enoylacyl-CoA hydratase.
Protein: SCXT_PARLS
Sequence: KDGYPVDNANCKYE
What is the function of this protein?
Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity).  Causes prolonged contractile paralysis in C. partellus larvae.  It also has significant toxic effects on B. fusca larvae but not on mice.
What are the official names of this protein?
Insect toxin PlIT.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: KC1A_SHEEP
Sequence: MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  Can phosphorylate a large number of proteins.  Participates in Wnt signaling.  Phosphorylates CTNNB1 at 'Ser-45' (By similarity).  May phosphorylate PER1 and PER2 (By similarity).  May play a role in segregating chromosomes during mitosis.  May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity).  Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).
What are the official names of this protein?
Casein kinase I isoform alpha, CKI-alpha, CK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton.
Protein: O16A_CONMA
Sequence: MKLTCVMIVAVLFLTTWTFVTADDSRYGLKNLFPKARHEMKNPEASKLNKRDGCYNAGTFCGIRPGLCCSEFCFLWCITFVDSG
What is the function of this protein?
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.
What are the official names of this protein?
Delta-conotoxin-like MVIA, Delta-MVIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TIG_LISMC
Sequence: MSVKWEKQEGNVGKLTFEIEQEKVKEGLDRAFVKVRKTLNVPGFRKGKVPRQIFNQRFGEEALFQDALDILLPEVYSAAIDEAGIDPVDTPQVNIESMEKGETWVLTAEVTVKPEVKLGDYKGLEVEKRETELTTEELEAELKQLQERQAELVVKEDAPAENGDTVILDFEGFKDGVAFEGGQAENHSLELGSGQFIPGFEEKLVGLKAGDEADIELTFPEEYHAEDLAGQPVVFKVKLHEIKTKEVPALDDELAKDIDEEVETLDELKEKISKRLQEAKEESVAQAKQEEVIAKAVENAEVDIPHAMVHHEADHLMNHFAQDLQAQGLTPELYYQFTGQTEEAMHAQMEKDAEKRVKMNLVLEAIAEAENIEPTEEAIDEEISTLAEKYGMEKDAVRAALGDMSELKSDLKIRKAIDVLLDSAVEK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RL36_AZOSB
Sequence: MRVQASVKRICRNCKIIRRKGVVRVICTDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: COQ4_DROPS
Sequence: MMQRCWRLPVPLGKRGLAVVTHTRQAVVSDNPEAENLDGFEQQYLKERIEITTFQRMLLGAGSSIAAILDPRRHDMIACLGETTGEDALWNIMDTMHESEEGQRIMVEKPRIHTSTIDFKRLESLPADTFGAAYVKFLKDNKVTPDSRMAVRFLEDPKLAYLMTRYRECHDLIHTVLDMPTNMLGEVAVKWVEALNTGLPMCYGGAVFGAVRLRPKQRRAYLKHYLPWALENGKQMKPLMPVYWEERWEQNVNELRAELGIKLLNKF
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial, Coenzyme Q biosynthesis protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ARNF_ECO81
Sequence: MGLMWGLFSVIIASAAQLSLGFAASHLPPMTHLWDFIAALLAFGLDARILLLGLLGYLLSVFCWYKTLHKLALSKAYALLSMSYVLVWIASMVLPGWEGTFSLKALLGVACIMSGLMLIFLPTTKQRY
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS7_THEMA
Sequence: MTVERLENGVIVQRNTNEIEISITLDTVHGKLEGSTGVNFFDHLLNTFCHYSGLGLRVSTCESKDGILHHLIEDFGISLGLAFRELFDYTKVRRFGEATVPMNEALVGCYVDLSGRPFFQKNFEFSVEKIEDMPVEGFEEFMCGFVNHARITVHFFKFFGKNDHHISESAMKSFGLAIAKALESSEKKTTKGVID
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y532_AQUAE
Sequence: MKRFLLLIILFGISFSFVSDYLLRAESLFSQLKDANAKEETPYLYGKVKGYYEAIKLYAVEYKEDRIKTLFTLMSKNTKKAVRGAYTEREPLTELITFEPRVYFEEYCDGIMDECFYEKHYEKEKFIELVDYFSLKRRVEFLRNHEGKYCAPFDFGMAEALFNAVSLELMQEKPDEKVLIALREKLEPILVMAEEKLRYAMKKELPCYRNRLSEHIGYWKP
What are the official names of this protein?
Uncharacterized protein aq_532.
Protein: RL22_PARD8
Sequence: MGARKRISAEARKEAQKTMYFAKLNNVPTSPRKMRLVADMIRGMEVFRALGVLKFSNKEAAARVEKLLRSAIANWEQKNERKAEAGELCVSSISVDCATTLKRMRPAPQGRGYRIRKRSNHVTLFVDTLSKNDSQN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.