PharMolix/UniProtQA huggingface dataset:
Protein: NU3M_DICCI
Sequence: MLVTVEFTYILILFFISLGLSIILFFLGYFLMFKVAYEDKLMGYECGFDPFGNARGEFDIRFYLVAILFLIFDLEITFLFPFSVSIMSMTLFSYSIMLIFLIILTIGFIYEIKKGALDWS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: ELOV7_DROME
Sequence: MDYLTMFYDGWRDLMDNKSDPRTRDYPLMSSPFPTIAISLTYAYIVKVLGPKLMENRKPFELRKVLIVYNAAQVIFSAWLFYESCIGGWLNGYNLRCEPVNYSYSPKAIRTAEGCWWYYFSKFTEFFDTFFFVMRKRYDQVSTLHVIHHGIMPVSVWWGVKFTPGGHSTFFGFLNTFVHIFMYAYYMLAAMGPKVQKYLWWKKYLTVMQMIQFVLVMVHSFQLFFKNDCNYPIGFAYFIGAHAVMFYFLFSNFYKRAYVKRDGKDKASVKANGHANGHVKALKDGDVAPTSNGQANGFHNTFSKFTTDMCNPALNSSTRQRVLVNAGNK
What is the function of this protein?
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle.  This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.
What are the official names of this protein?
Elongation of very long chain fatty acids protein 7, ELOVL fatty acid elongase 7, Very-long-chain 3-oxoacyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the ELO family.
Protein: SIRTM_STRPG
Sequence: MSNWTTYPQKNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQKS
What is the function of this protein?
Catalyzes specifically the mono-ADP-ribosylation of GcvH-L (SpyM50867).  This activity is dependent on prior lipoylation of the target protein.  May be involved in the modulation of the response to host-derived oxidative stress.  In contrast to other sirtuin classes, lacks protein deacylase activity, being unable to catalyze debiotinylation, deacetylation and desuccinylation of proteins.
What are the official names of this protein?
Protein ADP-ribosyltransferase, Sirtuin class M, SirTM.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class M subfamily.
Protein: VE1_HPV30
Sequence: MASPEGTDDEGGGCTGWFHVEAVVKKRTGDIISEDETEEDEGTASDLDGFLDNSNVITTQADRETAQQLLHAQNTYADTQTLHNLKRKYLGSPLGDISNQQFVCREGVKRRIIDTDVADSGYGNTLEVEATQQVQDNTYGSGKQQDGGSQTSVCSRENSIEADSDMDIGATPPQQIQELLKSSNVQAKLCYKFKELFGIPFSELVRTFKSDSTCCHDWICAMFGVNETLAEALKTIIKSQCMYYHIQCLTCTWGVVILMLIRYTCGKNRKTIIKSLSSIVNVPSEQMLVQPPKIRSPAVALYFYKTAMSNISDIYGETPEWIQRQTQIQHSFQDCQFELSKMVQWAFDNDVTDDSDIAFYYAQLADVDSNAQAFLKSNMQAKYVKDCGIMCRHYKRAQQQQMNMKQWITHICSKVDEGGDWRPIVQFLRYQGVDFISFLSYFKLFLRGTPKHNCLVLYGPPNTGKSCFAMSLIQFFQGSVISYVNSHSHFWLQPLDNAKLGMLDDATDACWRYIDEYMRNLLDGNPVSLDRKHKQLVQIKCPPVIITTNINPLHDAKLQYLHSRIHVVPFLNPFPIDTNGNPVYQLNNVNWKCFFERTWSRLDLNNDEDKENHGDSMPTFRCVPGENSRLF
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: KEFC_ECO55
Sequence: MDSHTLVQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLWKLRAAVFGGGALQMVICGGLLGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAIPLVAMIPLLATSSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILLLGFLIIKIAMLWLIARPLQVPNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEEAREADEIDEEQPRVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQLTEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAMVENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefC, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL18_BURP0
Sequence: MDKTQSRLRRARQTRIKIAELQVARLAVHRTNTHIYAQVFSPCGTKVLASASTLEAEVRAQLADKSGKGGNVAAATLIGKRIAEKAKAAGIESVAFDRSGFRYHGRVKALAEAAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: DEFCO_COPCI
Sequence: MKLSTSLLAIVAVASTFIGNALSATTVPGCFAECIDKAAVAVNCAAGDIDCLQASSQFATIVSECVATSDCTALSPGSASDADSINKTFNILSGLGFIDEADAFSAADVPEERDLTGLGRVLPVEKRQNCPTRRGLCVTSGLTACRNHCRSCHRGDVGCVRCSNAQCTGFLGTTCTCINPCPRC
What is the function of this protein?
Antimicrobial peptide that acts against Gram-positive bacteria (Listeria spp. , Enterococcus spp. , B. subtilis, B. anthracis, P. aeruginosa) (PubMed:25342741, PubMed:28825809).  Is not active against Gram-negative bacteria (PubMed:25342741).  It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio), probably anchoring lipid II to the membrane, thus inhibiting cell wall synthesis (PubMed:25342741, PubMed:28825809).  The interaction with lipid II involves the third position of the pentapeptide (PubMed:25342741).  Shows bactericidal activity at about 2-fold minimal inhibitory concentrations (MIC), but does not form pore across the membrane (PubMed:25342741).
What are the official names of this protein?
Fungal defensin copsin.
What is the protein family that this protein belongs to?
Belongs to the invertebrate defensin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=specific localization at active cell wall synthesis sites.
Protein: NUOA_ECOL6
Sequence: MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARSKNVPFESGIDSVGSARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLVRIGALDWTPARSRRERMNPETNSIANRQR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HID1_MOUSE
Sequence: MGSADSKLNFRKAVIQLTTKTQPVEATDNAFWDQFWADTATSVQDVFALVPAAEIRAVREESPSNLATLCYKAVEKLVQGAEGGCHSEKEKQVVLNCSRLLTRVLPYIFEDPDWRGFFWSTVPGAGRGGQGEEEDENARPLAESLLLAIADLLFCPDFTVQNHRRNDVDSAEDVHSLDSCEYIWEAGVGFAHSPQPNYIHDMNRMELLKLLLTCFSEAMYLPPSPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSATSTSPTVDGTTTGTAMDDADPPGPENLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPNSTKKIQFHQELLVLFWKLCDFNKKFLFFVLKSSDVLDILVPILYFLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSVRVPMDIPVFTGTHADLLIVVFHKIITSGHQRLQPLFDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTWFLFSASQNHHLVFFLLEVFNNIIQYQFDGNSNLVYAIIRKRAVFHQLANLPTDPPSIHKALQRRRRTPEPLSRTGSQEGTSMEGSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVSEDGTLRSLEPESQQSSAENSPSDGESSQTWREQRRLSNASASGQWSPTSDWILSWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDESEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAMWFRTYMWGVIYLRNVDPPIWYDTDVKLFEIQRV
What are the official names of this protein?
Protein HID1, HID1 domain-containing protein, Protein hid-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the hid-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the cytosol and the Golgi apparatus.
Protein: ARGB_SYNJA
Sequence: MACDPLTRAQILIEALPYIQQYQGRVIVIKYGGAAMVHQERRAEVLRDIVFLACVGIRPVLVHGGGPEINSWLQKLDIPFKFVDGLRVTDAATMEVVEMVLVGKVNKQIVQLISLAGGSAVGLCGRDGNLIRARSQGRAEIGFVGEVSSINPQLVQTLLEGGQIPVISSVAADETGQAYNINADTVAGELAASLGAEKLILLTDTPGILRDPEDPSSLITLLDIETARQLIQTGVVRGGMIPKVQCCIRALAQGVRAAHILDGGSPHSLLLELLTDAGVGTKLIPSQFSAQLREQSNGFR
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLKA_DICDI
Sequence: MDRFQTKRKTYSYNGYSNNDYGYYNNNCSNVNYNNDIHYKNNNYNNNNNNNNSNSGNNFNNNNNNNNNNNNNNNNNNNNNNNNNNYTYGNNNNNNSNNNNNNINNNGNSNNNNNNSNGSENNYFQSENQSNKDQNSYFNSSYLRNPVDNYNHNNNNHNNNAFDNNNYNTQNLGDYSYKNDGYNNDNNNNDNNNSYGDTDREKYSIEKICNENDYDSVNNNNNNRNYSNSYNNNNYNDGNNNYNSNNYNYNNNNNNNNNINNNNNSNSNSNSNSNSNSNSNSNSNSNNNNYNNYGYNNHKSNNGGNRYSDDDDNVFNNNNNNNNNNNNNYNNYNSNNNYNNDYDYNDGKRANIYSRNNSNNNNNSKSGNNNSNNYNHNNSNNNGGYNNYNNGYNNYNNNNSNNSNHNSSYNNNNNNNYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNISNNSNNNNFNYNNDNDRNNSNGNYNNNSSNINNNNNNNNNSNSYHNSCISYSNGGSNSKNSNKNNYNNQQSNANGNHVGNSKNNESCNNTNTNIEKSNKSMWDDENDYYKVQVGEYLNNRYKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTEDALVEIDILRNLEKTGNSNGKYLSHCIRLLDSFLFKDHICLVFKRYGLSLYEFLKKNRYRPLPLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENILLESSRFTYFDNSIPLQFKNSIDTTSNNSVDHYCHLVDTDIVVIDFGGATFENTHHTAIVCSRPYRPPEIILGMGWSYPCDIWGVGCILVELYLGYTLFDTHNNVQHLAMMEKVMGPFPNSMSNVSKKYFNDYGTLNRPQNSDEIKSMERVEGLKQLKEYFHPCHDSFFDLASRLLEYQPSKRISASDALSHPFLFETIENDCFGPI
What are the official names of this protein?
Probable serine/threonine-protein kinase clkA, CDC2-like kinase A.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
Protein: CSMB_PROVB
Sequence: MSNGTNIDVAGAINTLTETFGKLFQMQVDVANNSLKALAEVAEPLGKTATDLVASFANVATQVLQNVSSAVAPKK
What is the function of this protein?
Component of the photosynthetic apparatus which may bind the chlorosome to the bacteriochlorophyll a protein monolayer.
What are the official names of this protein?
Chlorosome envelope protein B, Chlorosome 7.5 kDa protein, Gerola-Olson chlorosome protein.
What is the protein family that this protein belongs to?
Belongs to the CsmB/CsmF family.
What are the subcellular locations of this protein?
Chlorosome, chlorosome envelope.
Protein: ANX13_HUMAN
Sequence: MGNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELSGNFEKTALALLDRPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIVVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALLH
What is the function of this protein?
Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A.  Half-maximal membrane binding requires about 320 uM calcium.
What are the official names of this protein?
Annexin A13, Annexin XIII, Annexin-13, Intestine-specific annexin, ISA.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
What are the subcellular locations of this protein?
Apical cell membrane. Cell membrane; Lipid-anchor. Cytoplasmic vesicle. Note=Myristoylation anchors the protein to the membrane, but the protein also displays calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946).
Protein: COAA_STRS7
Sequence: MSNEFITFEKISRKSWKQLHQKSKPLLTQEELTNITSLNDNIDINDVIEVYLPLIHLIQIYKIAQENLSFSKSLFLKKDIQQRPFIIGISGSVAVGKSTTSRLLQLLLARTHKTSTVELVTTDGFLYPNSTLIKNNMLNRKGFPESYNMELLLNFLDTVKGGQTASAPVYSHEIYDIVPDQQQTFTNPDFLIIEGINVFQNQQNNRLYMSDYFDFSIYIDADSHHIEQWYLERFLSLLELAKHDPANYYARYTSLPQNEAIAFAKKVWKTINLENLEKFIEPTRNRAELILHKAADHKIDEIYLKK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O161_CONAJ
Sequence: MKLTCVMIVAVLFLTAWTFATADDPRNGLGNLFSNAHHEMKNPEASKLNKRWCKQSGEMCNLLDQNCCEGYCIVLVCT
What is the function of this protein?
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.
What are the official names of this protein?
Delta-conotoxin-like Ai6.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYCC_BURCE
Sequence: MALADDLKKWVGETFTGKWEVQETTSVPNPEDLRLNSNHAKDLKAATVLYADLDGSTDMVNTKKWQFSAQIYKTFLKCASDIIRDEGGNITAYDGDRVMAVFTGNSKNTSAARCALKINSAVLDIIQPAIAKKWQTDFVLRHVVGIDTSQLRTARIGIRGDNDLVWIGRAANYAAKLTNLAGKPTRITADVYNKLADKLKYANGVDMWAPEHWDDMGIWTYTSTWKWTV
What is the function of this protein?
The pyrimidine cyclase gene of a two-gene Pycsar system, generates cyclic UMP (cUMP) from UTP, has little to no activity on ATP, CTP or GTP (PubMed:34644530).  Expression of this and adjacent effector BcPycTIR (AC A0A0J5WTU0) probably confers resistance to bacteriophage.  The genes are probably only expressed in response to bacteriophage infection (Probable).
What are the official names of this protein?
Uridylate cyclase, BcPycC, Cyclic UMP synthase, cUMP synthase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Pyrimidine cyclase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_FRATH
Sequence: MAKKKIEAIIKLQVAAGKANPSPPIGPALGQHGVNIMGFCKEFNAKTQGMEPGMPIPVEISVYSDRSFTFEMKTPPASYLIKKAINVKSGSSKPSKEFIGTITRAQLEEIAKVKDPDLTAADLDAAVRIIAGSARSMGVKVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: Y521_ALKEH
Sequence: MANPVGAIRQRCAAIGEQLQGVDWLRVAVDFPLYVAERFRRDACLQNAATLSYTTLLALVPLLTIGLSIFAAFPVFSGLTEQMLDLLFENLVPASTAVVQQHLEDFVGRAAGLTVVGLLALMVSALLMMAAIDRAMNDIWRVQQRRRPLHGFMVYWTVLTLAPILMGASLGISSYVISVTRFGELEALSGLQGLLLAGMPFVAETVAFTFLYAAVPNFRVPLRHALLGGLLAAALFEAAKGGFGWYVANIPTYEAIYGALAALPIFLIWLYLSWVVVLVGAEFTQALASYSVARHRAAGTGRDAFRLAVRVLGHLWRAQREGRGLSTRALSRLEPAAGEMGVLQVLRPLRRARAIQLNGEGEWMLARDPSHYTLLDLYRSEAFPLPSVAALRKDGDDWDQRLADSLAQADTGLASGLAESLDDIFTSRPQIRPVVRQANSPSEER
What are the official names of this protein?
UPF0761 membrane protein Mlg_0521.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MCRZ_METTM
Sequence: MSYKAQYTPGETQIAENRRKHMDPDYEFRKLREVSDEDLVKVLGHRNPGESYKSVHPPLDEMDFEEDIVRDMVEPIQGAKEGVRVRYIQFADSMYNAPAQPYDRARTYMWRYRGVDTGTLSGRQVIEMRELDLEGVSKELVETELFDPATTGIRGATVHGHSLRLDENGLMFDALQRYVFDEEKGHVVYVKDQVGRPLDEPVDMGQPLGEDELKKITTIYRKDNIAMRDDKEAIEVVENIHTGRTLGGFGMDVFKDDLRKRLGDD
What is the function of this protein?
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB).  This is the final step in methanogenesis.
What are the official names of this protein?
Methyl-coenzyme M reductase II subunit gamma, MCR II gamma.
What is the protein family that this protein belongs to?
Belongs to the methyl-coenzyme M reductase gamma subunit family.
Protein: KAE1_THEKO
Sequence: MIALGIEGTAHTLGIGIVTEKSVLANVFDTLTTEKGGIHPKEAAEHHARLLKPLLRKALETAGVTMEDVDLIAFSQGPGLGPALRVVATAARALAIKYNKPIVGVNHCIAHVEITKMFGVKDPVGLYVSGGNTQVLALEGGRYRVFGETLDIGIGNAIDTFARELGIGFPGGPKIEKLALKGEKYIELPYAVKGMDLSFSGVLTEAVRKYRTGKYRIEDLAYSFQETAFAALVEVTERAVAHTGKEEVVLVGGVAANNRLREMLKIMAEDRGIKFFVPPYDLCRDNGAMIAYTGLRMYRGGVRFKIEDTVVKQKFRTDEVEVVWD
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1, tRNA threonylcarbamoyladenosine biosynthesis protein Kae1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTNB_SHIFL
Sequence: MATAGMLLKLNSQMNREFYASNLYLHLSNWCSEQSLNGTATFLRAQAQSNVTQMMRMFNFMKSVGATPIVKAIDVPGEKLNSLEELFQKTMEEYEQRSSTLAQLADEAKELNDDSTVNFLRDLEKEQQHDGLLLQTILDEVRSAKLAGMCPVQTDQHVLNVVSHQLH
What are the official names of this protein?
Bacterial non-heme ferritin-like protein.
What is the protein family that this protein belongs to?
Belongs to the ferritin family. Prokaryotic subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COA6_HUMAN
Sequence: MGPGGPLLSPSRGFLLCKTGWHSNRLLGDCGPHTPVSTALSFIAVGMAAPSMKERQVCWGARDEYWKCLDENLEDASQCKKLRSSFESSCPQQWIKYFDKRRDYLKFKEKFEAGQFEPSETTAKS
What is the function of this protein?
Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2.  Thereby, may regulate early steps of complex IV assembly.  Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis.  May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
What are the official names of this protein?
Cytochrome c oxidase assembly factor 6 homolog.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 6B family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: SYR_ECOHS
Sequence: MNIQALLSEKVRQAMIAAGAPADCEPQVRQSAKVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLNGIASKVEIAGPGFINIFLDPAFLAEHVQQALASDRLGVATPEKQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHKVIRANHVGDWGTQFGMLIAWLEKQQQENAGEMELADLEGFYRDAKKHYDEDEEFAERARNYVVKLQSGDEYFREMWRKLVDITMTQNQITYDRLNVTLTRDDVMGESLYNPMLPGIVADLKAKGLAVESEGATVVFLDEFKNKEGEPMGVIIQKKDGGYLYTTTDIACAKYRYETLHADRVLYYIDSRQHQHLMQAWAIVRKAGYVPESVPLEHHMFGMMLGKDGKPFKTRAGGTVKLADLLDEALERARRLVAEKNPDMPADGLEKLANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKAEIDEEQLAAAPVIIREDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDLAGLFSGFYEHCPILSAENEEVRNSRLKLAQLTAKTLKLGLDTLGIETVERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_BURO0
Sequence: MSLKKSPFFELRSGSVDTLLFTVKTTDLDALRAELVKRFEATPEFFADDVVAIDVRRLADGERVALADIRQMLNDVRMRPVGVVALATQGWAGEAGLPLLEARDRRAPAAKPADEAEPAAVPAVETAAAPAAAAAPEQSSDPAPTLVQAGGQTLVIDRPLRSGQQIYAKGDLVVLAPVSHGAEIIAEGNIHIYAPLRGRALAGVHGNHDARIFCTCLEPELISIAGIYRTTENPLPADVLGKSVQIRLEEEKLMIEPLRLT
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: RECR_RHOPB
Sequence: MAAAVAGPEIERLIQLLAKLPGLGPRSARRAALHLIKKREALMAPLASALQVAIERIQVCKVCGNIDTQNPCTVCTDPRRDPSIIVVVADVADLWALERAHAASGRYHVLGATLSPLDGVGPDDLSIDALVARAHDPQVSEIVLALNATVDGQTTAHYITDLLMEAGVKVTRLAHGVPVGGELDYLDEGTLSAAMRQRTLF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: TPMT_VIBVY
Sequence: MRDAEFWHNKWASNQIGFHLEDVNPLLTRFWSALAPKREETVLVPLCGKTEDLAWLATKHDHVEGAELSLIAVRSFFAEHFYTPTVTPISGQHELYQFDELSIYAGDFFTAPLSKADLIYDRAALIALPEEMRVEYVQRIRGLLNPGGRILLVSLDYPQQEMAGPPFSVTQEEIEHLFAGMHVTRLYQDIADEHHPKIAKQGLSRFSEEVYVIENDK
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAS_ORITS
Sequence: MRKIMLIASAMSALSLPFSANAIEFDENSLECGPYAKVGIVGGVLSGVESARLDPADSEGKKHLPLIKGMPFGVTLAAGMTITPGVRAEISAMYLMNVKAEVELGKMGSDANTGTTADASAGVIRKHKKLTPPQPNIMPISIADRDIAVDIPNAAGQGNVDVRAAARIAWLKNYAGIDYYVPDSNNPQGRVVNPVLLNIPQGNPNPAGGGGRAAPAAFDILDHAQWRDVVVGITALSNANKPNVSAVKILSDKISQIYADIKPFANVASVQISETPLPDSASVDQIQNKVQELNKVLEDVRESFDGFILNAFAQPVRLNFQIPQVVQGQGQQPQAAATAQEAAAAAAIRALNDGENNGIIQLYKDLYKLQRNVALKKSMKQLGDELGVDQGQEGGCSKDKKQSDTTAEESKKEGKKGKEIEFDLHMAVGQVKLYADLFTIDSFSVYAGIGAGLAYTHGKIDGKDIKAHTGMVGSLALGVAANVADGVYMDVDAGYLYSFSKIEEKYQMNAFVASAGIRYNF
What is the function of this protein?
May be an adherent factor for rickettsial adsorption to the host-cell surface and a determinant of virulence of individual rickettsial strain.  It is the major outer membrane protein.
What are the official names of this protein?
56 kDa type-specific antigen, TSA, 56 kDa scrub typhus antigen, STA56, TSS56.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.