PharMolix/UniProtQA huggingface dataset:
Protein: RSMG_PROMT
Sequence: MSTDKKNRTASHLMIWNELKWAPSEKQLAQFIHLQELLKEWNKKINLTRLVDGDDFWTAQVCDSLLPLYEELQHPEVSHKYIDIGSGCGFPGIAIAIAMPNSNITLLDSSSKKTTFLKEVSKEIGLDSRIKVVTERAEEAGRNPIFRSNFDYAIARAVASANVVAEYLVPFLNSTGQALIFKGSWSETEQQILKKALAELNAEIQRTHEFILPNNRGIRNIIRINSTNKCPHQYPRSIGKPKKQPLGY
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGX_SHIF8
Sequence: MTQLAIGKPAPLGAHYDGQGVNFTLFSAHAERVELCVFDANGQEHRYDLPGNSGDIWHGYLPDARPGLRYGYRVHGPWQPAEGHRFNPAKLLIDPCARQIDGEFKDNPLLHAGHNEPDYRDNAAIAPKCVVVVDHYDWEDDAPPRTPWGSTIIYEAHVKGLTYLHPEIPVEIRGTYKALGHPVMINYLKQLGITALELLPVAQFASEPRLQRMGLSNYWGYNPVAMFALHPAYACSPETALDEFRDAIKALHKAGIEVILDIVLNHSAELDLDGPLFSLRGIDNRSYYWIREDGDYHNWTGCGNTLNLSHPAVVDYASACLRYWVETCHVDGFRFDLAAVMGRTPEFRQDAPLFTAIQNCPVLSQVKLIAEPWDIAPSGYQVGNFPPLFAEWNDHFRDAARRFWLHYDLPLGAFAGRFAASSDVFKRNGRLPSAAINLVTAHDGFTLRDCVCFNHKHNEANGEENRDGTNNNYSNNHGKEGLGGTLDLVERRRDSIHALLTTLLLSQGTPMLLAGDEHGHSQHGNNNAYCQDNQLNWLDWSQASSGLTAFTAALIHLRKRIPALVENRWWEEGDGNVRWLNRYAQPLSTDEWQNGPKQLQILLSDRFLIAINATLEVTEIVLPAGEWHAIPPFAGEDNPVITVVWQGPAHGLCVFQR
What is the function of this protein?
Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.
What are the official names of this protein?
Glycogen debranching enzyme, Limit dextrin alpha-1,6-maltotetraose-hydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: RBL_LAVLA
Sequence: MSPQTETKASVGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPQEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYNIEPVPGEKDQYICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYIKTFQGPPHGIQVERDKLNTYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLSHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDFVEKDRSRGIYFTQDWVSLPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNPPGAVANRVALEACVQARNEGRDLAAEGNAIIREACKWSPELAAACEVWKEIKFEFPAMD
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YMA7_CAEEL
Sequence: MSGHSYASVVDRIYSRKSSELYDNIAYLHHPSGVTVVVLRNIPESEVVEVDFGTTKKHGADRSTNQVSGKGKKGALILQPDSKLCTFKCKDGSEHVVRAGVRGTLVEMNDRLKTTPDFIRTAPDNQGFIAIITYGAGVRETEGMGDDLPPKRLFLKS
What are the official names of this protein?
Uncharacterized protein F54F2.7.
Protein: RSGA1_LISIN
Sequence: MILEKYGFTSFFEEQKIAATSSYGRVTAVFRDFYRVITENGEFLATLKRGNFYELSPSNLPAVGDFVEVSNEKQILSVLQRKTIFSRMTKDSEEQLIAANFDYALIVMSLNHDFNLNRLERYLTVAWDSGATPIIILTKADLVDDLTPFTMELETVAYGVPTYYVDNLSHRGFEALEADLKPNSTLVLLGSSGVGKSSFINSLAGADLMKTSEIREDDSKGKHTTTHREMHLLANGWIIIDTPGMREFGIGLNQAGLETTFSDVEELSKDCRFHDCSHTSEPGCAVQESLADGTLSLKHYENWQKLQREMAYHARKNSPALARQERDRWKTIQKSLRTHLKTRPKR
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRP54_MYCLE
Sequence: MFESLSNRLTGVIQGLRGKGRLTDADIEATTREIRLALFEADVSLPVVRAFVHRIKERARGTEVSAALNPAQQIVKIVNEELIGILGGETRQLAFAKTPPTVVMLAGLQGSGKTTLAGKLAVRLRRQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPDSGPGDPVAVASAGLVEARAKHFDVVIVDTAGRLGIDDELMAQAGAIREAINPDEVLFVLDAMIGQDAVTTAAAFGAGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFATTGEKLDDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAEQAEAAAAKIVAGELTLEDFLEQMLAVRKMGLIGNLLGMLPGAGQVKEVLEQVDDKQLDRLQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQLVDRFFEARKMMSSVLGGMGIPGMGRKSATRKSKGGKGKKRARGPTSPKVRSPFGPARPGMPDMMNMPPSFPDLSQMPDGLNELPPGLAAFDLSKLKFPGKT
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle protein, Fifty-four homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: RL36_HELMI
Sequence: MKVRPSVKTICDKCKIIKRKGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: CAF4_CANGA
Sequence: MVNIVEKQNRLSLISLSLVSIRYKSWDFLYRILHGSIFDYIIGPRKELLLYFKCVYDSTFFNGKNYFSNLFTDTATSFRLLTFLNEHDLKSIPPLPLDKCQGLDSYSTLYDGYIVQSSHESQGLYDGSGKDGNDYTMKMQIMKNVLEMQINEMDDEIKRIKLRRNVVAKKLDVIISRIVDHKENKSKTDGSTEDEVHIGNTSSVLKQTNHEHTIITSENNTDDKVSLLTLEPDNAQIGNKLQRYFEAMKLKKKSSGFDIEDFENIIGTKGQLGKTLKCHDDYINSLAINAQLGVLSSTANLDNEIKLWDISTTQCLGVLSGHRATVNTTRFIDDTRLLASAGKDASVKVWDVDNIVDKDGNANDNLCLATFDGHKDSVTALATTGNAIVSGSNDKTLRHWDLGSGKCIQSIDLTIALKMVPQSVSKLDITPSFNTPLIGGADCIDNALVTGTKDGIVYLWDLRIGRVVGSLEGHRGPITSLKYMGSELITGSMDKSTRIWDLRMGSVAELLSFEKEVVSVEESQTQLINALEGEPVKIYDRGERQYNSLPDSFNTTTLVVYESLLALGNDHGDITWWSL
What is the function of this protein?
Involved in mitochondrial fission.  Has a partially redundant function to MDV1 in acting as an adapter protein required to form mitochondrial fission complexes.  Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).
What are the official names of this protein?
CCR4-associated factor 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MDV1/CAF4 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AGUA_SHEON
Sequence: MTNVNVDVTPLTTKPSQDGFYMPAEWAAQQAVWMIWPYRPDNWRAAGAYAQATFAKVVDAIGAATPVYMGVPKAFLAKAKTVMPSHVTLVEMDSNDCWARDTGPTVVVNAEGECRGVDWGFNAWGGHNGGLYFPWDKDEQVAQQMLAQHGFARYRAPLILEGGSIHVDGEGTCMTSAECLLNANRNPELTKEQIEGLLRDYLNVKQFIWLQDGVYMDETDGHIDNMCCFARPGEVILHWTDDESDPQYPRSKAALEVLQNTVDAQGRKLKIHLLPQPGPLYCSEEESKGVTEGTGVPRTAGERLAGSYVNFLITNHRIVFPLLDPATDDIAAQKLQEIFPEHEIVGVPAREILLGGGNIHCITQQIPAGK
What are the official names of this protein?
Putative agmatine deiminase, Agmatine iminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the agmatine deiminase family.
Protein: NEMO_MOUSE
Sequence: MNKHPWKNQLSEMVQPSGGPAEDQDMLGEESSLGKPAMLHLPSEQGTPETLQRCLEENQELRDAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEKLDLRSQREQALKELEQLKKCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKDRQALEGRIRAVSEQVRQLESEREVLQQQHSVQVDQLRMQNQSVEAALRMERQAASEEKRKLAQLQAAYHQLFQDYDSHIKSSKGMQLEDLRQQLQQAEEALVAKQELIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERHAREKLVEKKEYLQEQLEQLQREFNKLKVGCHESARIEDMRKRHVETPQPPLLPAPAHHSFHLALSNQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
What is the function of this protein?
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:9927690).  Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways.  Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin.  Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity.  Essential for viral activation of IRF3.  Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).
What are the official names of this protein?
NF-kappa-B essential modulator, NEMO, IkB kinase-associated protein 1, IKKAP1, mFIP-3, Inhibitor of nuclear factor kappa-B kinase subunit gamma, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modifier.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
Protein: TTY10_HUMAN
Sequence: MKLQTLMDWEEAHEKNRKNKRKAEALVAALQTCRVQDPPGTSTDCYLLPVLKPGHFKKNCPSHKKKPP
What are the official names of this protein?
Putative transcript Y 10 protein.
Protein: APAH_SHEB8
Sequence: MAHYFVGDIQGCFAELQKLLAKVDFNPSRDELWAVGDLVARGPDSLATLRFFRSLGDSAKTVLGNHDLHLMALHGKLKRAKPSDNLTEILESPDISASIDWLRQQPLMRELPEHQLIMSHAGVPPQWSLEVLREEAALVSCALKQDDYLEALIAQMYSDSAEQWDPSAIGIERLRYCINALTRMRYLYVDGRLDFDCKQPPENCTNPQLKPWFEFVSPLRQSHTLVFGHWAALMGNVGDTKLKALDTGCCWGEHLTLWHLEKDQKITQKKLKKS
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: RS7_BURA4
Sequence: MPRRREVPKREVLPDPKFGNVDVAKFMNMLMLSGKKSVAERIVYGAFEQIQTKGGKDPLEVFTVALNNVKPVVEVKSRRVGGANYQVPVEVRPSRRMALAMRWLREAAKKRSEKSMALRLAGELSEAAEGRGGAMKKRDEVHRMAEANRAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RL35_SHEPC
Sequence: MPKMKTDRGVAKRFKKTANGFKRKQAHLRHILTKKSTKRKRHLRAKCLVSKADVPAIARQLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: COAE_STUST
Sequence: MKPWILGLTGGIGSGKSAVVEQFGRLGVHWVDADHAARWVVEPGKPALARIAEHFGDGVLTPAGELDRAVLRARVFENAGERRWLEQLLHPLIRQEIAEHLSRAQSPYAILVSPLLIEAGQYRQADRVLVVDVPESLQLQRAMRRDQASEAQIRAILKAQASREERLRHADDVLVNDRDRAWLEAEVARLHDFYLTLRGGQP
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
Protein: TKN_KASSE
Sequence: DVPKSDQFVGLM
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
What are the official names of this protein?
Kassinin.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FABD_BUCAP
Sequence: MNSFAMLFPGQGSQYKNMLSSFFQKKNNLFKKIFDEASEYVNYNLLNLIKNGAKKKRDDYKYIQSAILTSSIAIYQLWKEKNGRRPALMSGHSLGEYSALVCANAIKFSDALKIVKLRSKLMQKIIINKPSLVQAIIGLDKVIIKNICLQYLPKIVSIASINSDDQIIISGEKLAVREVGLKCKKKGAKYVIKLNINTPIHSQLMKPVSEQIKYLLKSIKIKSPQIPVINNVDVICEKNEKKIKKALVRQFYSTVRWKEIIDLIKSKKIFTMLEIGPNKILSNLIKKNDNITVLNTNNLKNFLIAFKTIH
What are the official names of this protein?
Malonyl CoA-acyl carrier protein transacylase, MCT.
What is the protein family that this protein belongs to?
Belongs to the FabD family.
Protein: RL32_EHRCJ
Sequence: MAVPKRKKSKSRRNMHRSHCRLRVPNIGIDKTTGEYKLSHHICLGGYYNEKQVLEVDTSGV
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: PUR5_ECO8A
Sequence: MTDKTSLSYKDAGVDIDAGNALVGRIKGVVKKTRRPEVMGGLGGFGALCALPQKYREPVLVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASAVISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVLIALGSSGPHSNGYSLVRKILEVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKVDVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNCGVGMIIALPAPEVDKALALLNANGENAWKIGIIKASDSEQRVVIE
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_PSEE4
Sequence: MAQQVSGRQPRYKRILLKLSGEALMGSEDFGIDPKVLDRMALEIGQLVGIGVQVGLVIGGGNLFRGAALSAAGMDRVTGDHMGMLATVMNGLAMRDALERSNIPALVMSAISMVGVTDHYDRRKAIRHLNTGDVVIFSAGTGNPFFTTDSAACLRAIEIDADVVLKATKVDGVYTADPFKDPHAEKFDHLTYDEVLDRKLGVMDLTAICLCRDHKMPLRVFNMNKPGALLNIVVGGAEGTLIEEGQA
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORML1_MOUSE
Sequence: MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFCSVPVAWTLTNIIHNLGMYVFLHAVKGTPFETPDQGRARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDPTHFILNTASLLSVLIPKMPQLHGVRIFGINKY
What is the function of this protein?
Negative regulator of sphingolipid synthesis.
What are the official names of this protein?
ORM1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the ORM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ALPK1_MOUSE
Sequence: MNNQDAVASILHECKQVLDRLLLETPDVSTEDKSEDQRCRASLPSELRTLIQEAEEMKWPFVPEKWQYKQAMSPEDKTNLQDVIGAGLQQLLAALRASILVQDCAAASAIVFLMDRFLYGLDVSGKLLQVAKGLHKLKPATPIAPQVVIRQARVSVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASVIGYLTLPQPDKKGISTSLGILADIFVSMSKTDYEKFKKSPKVNLALLKEFDHHLLSAAEACKLAAAFSAYTPLFVLRAVNIRGTCLLSYSCSADCPPGMKSVHLCEAKEAFEIGLLTKKDGELVSGKQELHSFIKAAFGLTTVHSRLHGETDAVRAARQLCSEAVGKLYTFSTSPTSQDREGLSQEIMSLISQVKGHLRVQSFPNLDVCSYVPESFKCGLDRLILHGHVDFQQILETYSQHHTSVCEVFESTCGNSKSNQRDTKSEVCITTLKTETNTADTMVATLERVSSQDSRSTASSKMSKKDQGKLQRERGRSWTRSKAFRVSLDLDMETETEPPNHSNGGTDVFNKSLRDNSSSCSWGRLSGLSSSTSWEEVNCAVQDVVRKGSGQEKHPVEAQSSEAVSEEPKRNRSSRAVFLSSKLRGVSLQTTGDDNLESSPSQLHNHTSILPFNAKDTCLASGAGLVETAEGSNNTSLQSSHSCGSDSWSLSSSDRFTDVTTNPSVQEEEPSGIMGDVPESKYDFKDWHGEKNGGTLTEICTGPELTFAPSSVDPEGETAESTDDGLSPSQVALGCLEGSHSMSTRRTFFPDGSVQNADSAKTGCSVRDQTVDPDASTVDEEGQMLDSTEVCSIGQDGAHRPRALRSGQSAEGPKSFVNGSRPSPIFDEDFSTTEEGEELGSMLKSSQNSSSYSPWWLKSPAFSRSSSDGESSWSLLNSSRSSFASLAGQTSQEILEARTLQPDDLEKLLAGVRHDWLLQRLENTGVLKSNQLQQAHSALLLKYSKKSELWTAQETVVYLGDYLKVKKKGKQRNAFWVHYLHQEETLGRYVGKEYKERKGLRHHFTDVERQMTAQHYVTEFNKRLYEQKIPTQIFYVPSTILLILEDRTIKGCISVEPYILGEFVKLSNNTKVVKNEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKDVTTNFGKRGIFYFFNNQHASCNEICHRLSLTRPSLEQTSKV
What is the function of this protein?
Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity).  Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836).  ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling (By similarity).  May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (By similarity).  May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (By similarity).  May play a role in ciliogenesis (By similarity).
What are the official names of this protein?
Alpha-protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Note=Localized to the basal body region of the photoreceptor cilium and the region of the adjacent centriole.
Protein: OMPR_ECO57
Sequence: MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQSNPMPIIMVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVLRRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA
What is the function of this protein?
Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes.  Plays a central role in both acid and osmotic stress responses.  Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription.
What are the official names of this protein?
DNA-binding dual transcriptional regulator OmpR, Transcriptional regulatory protein OmpR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYOE_ECODH
Sequence: MMFKQYLQVTKPGIIFGNLISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLISPAVSLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGEFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLSLGGYAGYKYLVVAAAVSVWWLGMALRGYKVADDRIWARKLFGFSIIAITALSVMMSVDFMVPDSHTLLAAVW
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Z324B_HUMAN
Sequence: MTFEDVAVYFSQEEWGLLDTAQRALYRHVMLENFTLVTSLGLSTSRPRVVIQLERGEEPWVPSGKDMTLARNTYGRLNSGSWSLTEDRDVSGEWPRAFPDTPPGMTTSVFPVADACHSVKSLQRQPGASPSQERKPTGVSVIYWERLLLGSRSDQASISLRLTSPLRPPKSSRPREKTFTEYRVPGRQPRTPERQKPCAQEVPGRAFGNASDLKAASGGRDRRMGAAWQEPHRLLGGQEPSTWDELGEALHAGEKSFECRACSKVFVKSSDLLKHLRTHTGERPYECTQCGKAFSQTSHLTQHQRIHSGETPYACPVCGKAFRHSSSLVRHQRIHTAEKSFRCSECGKAFSHGSNLSQHRKIHAGGRPYACAQCGRRFCRNSHLIQHERTHTGEKPFVCALCGAAFSQGSSLFLHQRVHTGEKPFACAQCGRSFSRSSNLTQHQLLHTGERPFRCVDCGKGFAKGAVLLSHRRIHTGEKPFVCTQCGRAFRERPALLHHQRIHTTEKTNAAAPDCTPGPGFLQGHHRKVRRGGKPSPVLKPAKV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 324B.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUOD_XANCB
Sequence: MSEYRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPYMDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEAVSGARMHAAYYRPGGVYRDLPDRMPKYKESRWHKGGALTKLNAAREGSMLDFLENFTDTFPSRVDEYETLLTENRIWKQRTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDVPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKWLKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYCAVEAPKGEFGCYLMSDGANKPFRVHLRAPGFAHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SWS_DROPS
Sequence: MDVLELLRVSGSNMYYSTFLADAWCYYISNQITMTMYLYCALGVLSMLFIGWFVYFKRLARLRLRHEIARSLSAVTMASGGDLRGPRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVIRFARRILQLRRENMPLEVRTVEPPAEYLEETMEGSDRVPPDALYMLQSIRIFGHFEKPIFLRLCKHTQLLELMGGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMAAFQEVFKDSPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRFKGSSQGAGPSVYCSQTTRQATGSASATASAAAASGTAGSTHTAVPRPASSLSRYSQDEQHTLSDPNPGIPNLELSGDSVNTLFGEVNGGARLNSYPPLYHQRESDGNLSTRRGSITQQEQPEVGPVPSIDMRLVKSSAVDSLRKELGLPEQDAHIIDPFVEVREMEPNVTLITEGNADDVCVWFVMTGTLAVYQGNADATRIKQDKTDLLIHYVHPGEIVGGLAMLTGEASAYTIRSRNHSRVAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRALYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRTTTGAPGAPVEANPVTHKYSTVALVPITDDVPLTPFTYELYHSLCAIGPVLRLTSDLARKQLGMNIFDASNEYRLTSWLAQQEDRNIITLYQCDNALSPWTQRCMRQADVVLIVGLGDHSHLVGKFEREIDRLALRTQKELVLLYPETASSKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPIDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHETFGDVNIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPGHLWRYCRASMSIAGVFPPFCDYRDGHLLLDGCYTNNVPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTAPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFEGMAKAGRLGRFNQWFSKEPPKRGNHASLNEYTFIDLAQIVCRLPETYGLNPSDLFSEDEDCDGYISEPTTLNTDVRRYQVPRGGNSLSLSETEMDMDSDVEMDLKMERKMDKATQSTPPLQSKAQILRRKHSKEEARHEWEIKREQKQELAREQELERERELSQKGTTAGATGYTPNAVIATQTSLIFMDEEDEMDKKKTKDNDRDEVRGSAEDKGKEKEEDKENRSNTNNETKNYL
What is the function of this protein?
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho).  This deacylation occurs at both sn-2 and sn-1 positions of PtdCho.  Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.  Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain.  Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).
What are the official names of this protein?
Neuropathy target esterase sws, Swiss cheese.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Sws tethers Pka-C3 to the membrane.
Protein: YG5Q_YEAST
Sequence: MQHFESSDKIEKDDDTSRIKLRSSSLAAPILEAVQEAQPFEEATFSNLQKIHPLTENSTCNGYVIYDKDGNLKSMKDTFGRNIKTPDISNPTRARNERPLDTIRGFEYSITKDPRWLQELETSKLGFKPRPGFAVINQDSQASINLSQLEEKVMESQKKKEKRHISRLSRLLCR
What are the official names of this protein?
Uncharacterized protein YGR273C.
What is the protein family that this protein belongs to?
To yeast YMR295c.