Protein: ROQA_PENRW
Sequence: MDSYLGRDTISFPLSKELEAEWTDNGEVLLRSHLLKACWALLLGRLSETHTITFAVLEQLVAPPRDACSKLVASSPHLETWQISDRPDSLLVDAAKETHREPLSGTQTSTAVVIRWHDELNGPTSLPYAFNAIVVLDCSISPAKVYMEYSRASLTVNQAWSQLTATVHILEQLVMSPGISLRELDFLGSYSTKLILQWNNPYSLARPQVCIHTLILEHCRSQPDAEALCAWDGSVTYAELDRFSLAVAHQLLSLGVGPESVVPLYFEKSRWTVVAMLGVLRAGGAFVLLDPSHPMPRLAEICSEVQATVVITSESLQELGRKLGPRAVTILDTINSHVDTGRNAFNTSVKPSNAAYVAFTSGSTGKPKGIVIEHQCFVANTLAQNAVQNINSQTRAFQFASYGFDSSILETLMTLVAGGCVCIPSEKQRLNGLADAIRGMRANWLELTPSVARFINPEEVPDVSSVLLVGEPMSQDHITQWSGSGKIQLLNAYGPAECSVVATVQPNVQLEDPQNIGCSYSSHCWITNPQDHDQLEPLGAVGELLISGPIVARGYLNQPHQKSFISNPRWATRFGIPPGERVYKTGDLVRYNLDDGALRYVGRKDREVKIHGQRVDLHEIEHHASRFQKGMLAVADVLQVNGGSAGKLLALFIVADNDETRMTKESFVVPMNDTLLDLVTSIKHWLRDCLPPYMIPTKYTFVNRFPLTRTGKLDRRALVDLGAASSHSSTREQPSNQRDKEDVELDPGLSAKENTLCSVFAEALGCLAINIGPEDGFYDMGGNSLAAIELVARARNHGLEITVADVIRLQNPRKIARCTAESKDVREISPFSLLVDTEQSLSAATAQCGIGREMIEDIYPCTPLQEGLMHLSITNPGAFMGTYRFSLAPSTDLYRVWAAWEQLWLVHPILRTRIIQLQDGQKLQVVTKQKLPFEDISGMDNCQPMNLGTPLARVTYHRGRGSSGSDSGIFLLTMHHALFDGWSYLQMLGDLQVIYAGDKLSPRPSFKHAINYISKLSIEEGRSFWSQELKDFQATMFPTSSRRPTTSPHWQVRSQQIILAESDMNWTLANKIKLAWTLVISSQTHSNDVVYGLTVSGRNAPVPEIDRIVGPTFATFPFRTQLEDDISVEDMLVQMRQHDVSIMPFEHVGLRRIAESSSDAALACGFQNLLTIRLQSLQMPPGALIELPENENHDLKFASYALSIVAQQEGTSLGVKAIFNSCILGADRTEALLEQFDTLLQRILREPGTKMKDLRTQLSPEWQQLAAINKKSPSHLRCLHDIINHFSITQPNSEAVCAWDGSLTYSELVALARRLAGLLQSFGSGSEPGAVIGICVERSKWFPVAILGVMMSGAAMVLLEPNFPTQRLRHILRDAGARTMICSTVFQEKCAGLVDDMLVLTHDIVTQADYDAWTPSAVSHHDPMYVAFTSGSTGAPKGVVIEHGMVYSMLKAHKDIIGASIASRGLLFASPAFDICLAEIVLILCSGGCVCVPSEAQRMNSLAKTMTTMQVNMAMLTPSVARTLAPAAIPCLQTLILGGEAPSASDLETWASRVKLHQSYGPAECAMYTTTTHPLTSSSDLGNVGSSQNASCWIVDPDNHDELQPVGSIGELLIGGPIVGRGYINRAQESAAAFICDPVWSENFPFLQGARLYKTGDLAILNADGSLNLVGRKDTQVKLNGQRIELHEIEHCAERYQHGTAVIAELIKPVGIQRPRLIMFVYDPATVETTVGIDSTCHDHRGLFLPPSRQNQAYLEGVRDHLNQHLPPYMIPSHFLSLSRLPLSPSGKADRKTLRQVASKMDRETLEMYLDNPVAEKRKPTTEQERFVRASFATALSLNEEAIGMDDSFFALGGDSITAMRVLTLCRRRNMAISMQEFLSKNTVTLFCKHVILIQGQAVDSKRQKLLDSQDLVRGEDHLVQFQHLDYQLDMVRSQLNLLKSDSIQEIYPCSDAHSGVLELYTSNYTSTAIFEIRATGSVTPMQVSNAWSQLVHRHVALRTVLMKEPKVHADYLHVVLDKGPAQILALPRSKNALSELKGLEPVKSWGLSPPHRLIIGHDHSGTLFMRLETGYALIDAFSMTILLEELSLLLQGQPLPERGVSYREYLSNLRSQSSAETLQYWTQVLYGVYPSHLPRVPVTQSPLPEPRSQSRCLPFAQSKRLDSFWRSNNLTITNVFQLAWALTLAHYTNSRDVCFGTITSGRDIPHLEVWNIVGSFFNVLPCRIAIEPTRTVIDTLRQNQEDIQRRNDHQYCSIPDMIRKSGIRSLDNNQQLFNTVLTVQNPFSIQSSTAKDGSNEIDVKLIDLEDATEYDLCVAILPSPSHLKVELRYWSTTVSEGYASDILDRLFSQLEQIVHHATKPDFVQVYECTKH
What is the function of this protein?
Dipeptide synthase; part of the gene cluster that mediates the biosynthesis of the mycotoxins roquefortine C and meleagrin (PubMed:22118684, PubMed:23776469).  The first stage is catalyzed by the dipeptide synthase roqA which condenses histidine and tryptophan to produce histidyltryptophanyldiketopiperazine (HTD) (PubMed:22118684, PubMed:23776469).  HTD is then converted to roquefortine C through two possible pathways (PubMed:23776469).  In the first pathway, prenyltransferase roqD transforms HTD to the intermediate roquefortine D, which is in turn converted to roquefortine C by the cytochrome P450 monooxygenase roqR (PubMed:23776469).  In the second pathway, HTD is first converted to the intermediate dehydrohistidyltryptophanyldi-ketopiperazine (DHTD) by roqR which is then prenylated by roqD to form roquefortine C (PubMed:23776469).  Roquefortine C can be further transformed to meleagrin via three more reactions including oxydation to glandicolin A by roqM, which is further reduced to glandicoline B by roqO (PubMed:23776469).  Finally, glandicoline B is converted to meleagrin by the glandicoline B O-methyltransferase roqN (PubMed:22118684, PubMed:23776469).  More studies identified further branching and additional metabolites produced by the roquefortine/meleagrin cluster, including roquefortine F, roquefortine L, roquefortine M, roquefortine N and neoxaline (PubMed:24225953).
What are the official names of this protein?
Nonribosomal peptide synthase roqA, Roquefortine/meleagrin synthesis protein A.