PharMolix/UniProtQA huggingface dataset:
Protein: TPST_ARATH
Sequence: MQMNSVWKLSLGLLLLSSVIGSFAELDFGHCETLVKKWADSSSSREEHVNKDKRSLKDLLFFLHVPRTGGRTYFHCFLRKLYDSSEECPRSYDKLHFNPRKEKCKLLATHDDYSLMAKLPRERTSVMTIVRDPIARVLSTYEFSVEVAARFLVHPNLTSASRMSSRIRKSNVISTLDIWPWKYLVPWMREDLFARRDARKLKEVVIIEDDNPYDMEEMLMPLHKYLDAPTAHDIIHNGATFQIAGLTNNSHLSEAHEVRHCVQKFKSLGESVLQVAKRRLDSMLYVGLTEEHRESASLFANVVGSQVLSQVVPSNATAKIKALKSEASVTISETGSDKSNIQNGTSEVTLNKAEAKSGNMTVKTLMEVYEGCITHLRKSQGTRRVNSLKRITPANFTRGTRTRVPKEVIQQIKSLNNLDVELYKYAKVIFAKEHELVSNKLISSSKRSIVDLPSELKSVLGEMGEEKLWKFVPVALMLLLIVLFFLFVNAKRRRTSKVKI
What is the function of this protein?
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.
What are the official names of this protein?
Protein-tyrosine sulfotransferase, Tyrosylprotein sulfotransferase.
Protein: GLMM_ALISL
Sequence: MAERKYFGTDGVRGLVGQSPITPEFVMKLGWAAGKVLAKQGTKKVIIGKDTRISGYMLESALEAGLAAAGLKAKFTGPMPTPAVAYLTQTFRAEAGIVISASHNPYYDNGIKFFSSEGTKLPDDVEMAIEAELDKPMTCVESALLGKASRLNDAAGRYIEFCKSTFPKELSLAGVKMVVDCAHGATYHIAPNVFKELGAEIITIGCEPNGTNINHEVGATDVRALQAKVLEEKADFGVAFDGDGDRIIMVDDLGNKVDGDQIAYIIARDALRRGELKGGVVGTLMTNMGMEVALRNLGIPFVRSNVGDRYVMEKLLENNWKIGAENSGHVILLDKVTTGDAIVAALQVIASIVGSKMSLKELCNGMTLFPQVLENIRFVGDNNPLDTELVKAAQADVETKLGDNGRVLLRKSGTEPLIRVMVEGENAELVQQYALQIVDAVKESC
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MVK_PYRAB
Sequence: MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQREVATAIKIAGGTPMITRISKEGLRIEEVRE
What is the function of this protein?
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP).  Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
What are the official names of this protein?
Mevalonate kinase, MK, MVK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_BRUA4
Sequence: MSSTEATVFDVIVIGGGHAGCEAASAAARAGARTALVTHRFDTIGVMSCNPAIGGLGKGHLVREIDALDGLMGRVADEAGIQFRLLNRRKGPAVRGPRTQADRKLYRLAMQKMIAAQDNLFVVEGGAHDLREEHGRITGVVLSDGRTLSCGAVVLTTGTFLNGLIHIGEKKIPAGRMGEKPALGLSERLTSFGFALGRLKTGTPPRLDGRTIDWQSLDMQSADEEPVPFSLMTDRITIPQIDCGITRTTPETHAVIRANLHRSAMYSGSIEGIGPRYCPSVEDKIVKFGDRDGHQIFLEPEGLDDDTVYPNGISTSLPEDVQLDILKTIPGLETAAMLQPGYAIEYDFIDPRELKRSLETRKVTGLFLAGQINGTTGYEEAGAQGLLAGINAARRASGGDPVIIQRTEAYIGVMVDDLTSRGVSEPYRMFTSRAEFRLSLRADNADQRLTPLADKLGILGHARKERFEARETALDEARSLTQSLTITPNLASRYDLRLNQDGVRRSAYDLLSYPEIDLDRLKSIWPELGAVDPATREALEIEAQYAVYMDRQKSDIAVMEREEQLLIPAGLDIDGISGLSNELKHKLKQRRPETIAEAQRVDGMTPAALALLIAQIKKFGYRQRAASELSEGQGAA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KYNU_XANCP
Sequence: MMTDPLSRSHAAALDAADPLRALRDAFVFPQHGGQDQTYFVGNSLGLQPRQARAMVSEVLDQWGALAVEGHFTGPTQWLTYHQLVRDGLARVVGAQPDEVVAMNTLTVNLHLMMASFYRPSAERAAILIEAGAFPSDRHAVESQLRLHGLDPDTHLIEVEPDAADGTLSMDAIAATIAQHGPRLALVLWPGIQYRTGQAFALGEIARLARAQGAAVGFDLAHAVGNIPLSLHDDGVDFAVWCHYKYLNAGPGAVGGCFVHARHAHSNLPRMAGWWGHEQPTRFRMEPQFVPSPGAEGWQLSNPPVLALAPLRASLELFDQAGMPALRAKSEQLTGHLEQLIHTRVPQVLQIVTPADPAQRGCQLSLRVAGGRTQGRALFEYLQSVGVLGDWREPDVIRIAPVPLYNRFCDLHQLVEHVETWAAA
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
Protein: SAHH_STRAA
Sequence: MSADFTDFKVADLSLAEFGRKEITLAEHEMPGLMSIRREYAEAQPLAGARVTGSLHMTVQTAVLIETLVALGAQVRWASCNIFSTQGHAAAAIAVGPDGTPDNPRAVPVFAWKGETLEEYWWCTEQALTWPDSPTGGPNMILDDGGDATLLVHKGVEYEKDGKVPSVDTAENDEHRVILELLNRTITDGSQKWTQLASEIRGVTEETTTGVHRLYEMQRDGVLLFPAINVNDAVTKSKFDNKYGCRHSLIDGINRATDVLIGGKTAVVFGYGDVGKAARSLRGQGARVIVTEIDPICALQAAMDGYQVTTLDEVVDKADIFITTTGNKDIIMAADMARMKHQAIVGNIGHFDNEIDMAGLAKVPGIVKDEIKPQVHTWTFPDGKKIIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELFTKPGDYPTGVYTLPKHLDEKVARLHLDALGVKLTTLRPEQASYIGVDVDGPYKSDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMAD4_PIG
Sequence: MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSGMLVKDEYVHDFEGQPSLATEGHSIQTIQHPPSNRASTETYSTPALLAPSESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYPPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
What is the function of this protein?
Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor).  Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling.  Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription.  Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta.  Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.  Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions.  May act as a tumor suppressor.  Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).  In muscle physiology, plays a central role in the balance between atrophy and hypertrophy.  When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4.  MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity).
What are the official names of this protein?
Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, SMAD family member 4, SMAD 4, Smad4.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation.
Protein: RTF1_MOUSE
Sequence: MRGRLCVGRAAAVAAAVAAAAVAVPLAGGQEGSQGGVRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKTRKVEKKGAMKKQANKAASSGSSDRDSSAESSAPEEGEVSDSESSSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEDDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVAESHNMRNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKTASDLSEDLFKVHDFDVKIDLQVPSSESKALAITSKAPPAKDGAPRRSLNLEDYKKRRGLI
What is the function of this protein?
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.  PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.  PAF1C is required for transcription of Hox and Wnt target genes.  PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1.  PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3).  PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription.  PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors.  Binds single-stranded DNA (By similarity).  Required for maximal induction of heat-shock genes.  Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex.
What are the official names of this protein?
RNA polymerase-associated protein RTF1 homolog.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: HIS6_ECOLU
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVEEVQKRGAGEIVLNMMNQDGVRNGYDLDQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINISELKAYLASQGVEIRIC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHLD_BACCE
Sequence: MKKKVLALGAAITLVAPLQSVAFAHENDGGQRFGVIPRWSAEDKHKEGVNSHLWIVNRAIDIMSRNTTLVKQDRVALLNEWRTELENGIYAADYENPYYDNSTFASHFYDPDNGKTYIPYAKQAKETGAKYFKLAGESYKNKDMKQAFFYLGLSLHYLGDVNQPMHAANFTNLSYPQGFHSKYENFVDTIKDNYKVTDGNGYWNWKGTNPEDWIHGAAVVAKQDYAGIVNDNTKDWFVRAAVSQEYADKWRAEVTPMTGKRLMDAQRVTAGYIQLWFDTYGNR
What is the function of this protein?
Required, with sphingomyelinase, to effect target cell lysis (hemolysis).
What are the official names of this protein?
Phospholipase C, PLC, Cereolysin A, Phosphatidylcholine cholinephosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the bacterial zinc-metallophospholipase C family.
Protein: HUTH_BRASB
Sequence: MSTIIAAPGRVSLDDLARVYAGATLELDPSYWPDVEAAAAIVAKAAQGAEPVYGINTGFGKLASKRIPPDQTAQLQRNLILSHCCGVGPVTPEAVVRLMMALKIISLGRGASGVRREIIEQLQAMLARGVCPFVPQQGSVGASGDLAPLAHMTAVMIGEGQAFVDGRLVPGREALAHAGLAPVTLGPKEGLALINGTQFSTAYALAGLLRAHDLLKAALVTGALSVDAAMASTAPFRPEIQALRGHPGQIAAGRVLTELLDGSAIRLSHLEGDERVQDPYCLRCQPQVAGAALDLLTQTARTLVTEANAVTDNPLVLVVTGEIISGGNFHAEPVAFAADQIALALSELGAISERRIATLVDPALNFGLPPFLTPQPGLNSGFMIAEVTAAALFAENKQRALPCSIDSTPTSANQEDHVSMAAHAARRLHDMADNLAHIIGIELLVAAQGIELRVPHGTSAALSAVIGALRVHVPALENDRYMADDLAKAAAIVAGGVLADAARDALGRDPFPKLG
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_MYCSJ
Sequence: MSWLQVIVLAVVQGLTEFLPVSSSGHLAIVSRVFFDDDAGASFTAVTQLGTEVAVLVYFARDIGRIATAWFRGLRNPGRRDADYRLGWYVIIGTIPIGVIGLLLKDEIRTAARNLWAIAIALIVFSAVIAAAEYFGRQVRHVEQLTWRDGVIVGVAQCLALLPGVSRSGATISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFAPVGEGMSATGPQLLVATVIAFVVGFAAVAWFLRFLVRHGMYWFVGYRVVLGVVVLILLSTGVVAAI
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HOOK1_MOUSE
Sequence: MEDPQPLPQSELPLCDSLIIWLQTFKTASPCQDVKQLTNGVTMAQVLHQIDVAWFSESWLSRIKDDVGDNWRIKASNLKKVLHGITSYYHEFLGQQISEELIPDLNQITECADPVELGRLLQLILGCAVNCEKKQEHIKNIMTLEESVQHVVMTAIQELMSKEIVISPASDTVGELEQQLKRALEELQEAIAEKEELKQRCQELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTMVAKKYFHVQLQLEQLQEENYRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEVYRQKLQDLNDLRKQVKSLQETNMMYMHNTVSLEEELKKANAARAQLETYKRQVQDLHTKLSSESKRADTLAFEMKRLEEKHETLLKEKERLIEQRDTLKETNEELRCSKAQQDHLNQADASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGTENERIEQLQEQLEQKHRKMNELETEQRLSKERIGELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDISQNAQKISELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKLRDYEEKLIVSAWYNKSLAFQKLGMESRLVSGASACKDSVAAAPARSFLAQQRHITNTRRNLSVKVPAAASD
What is the function of this protein?
Component of the FTS/Hook/FHIP complex (FHF complex).  The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).  FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (By similarity).  Required for spermatid differentiation.  Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (PubMed:12075009).
What are the official names of this protein?
Protein Hook homolog 1, mHK1.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (PubMed:12075009). Often found in close association with microtubules (PubMed:12075009). Does not associate with the Golgi complex (PubMed:12075009). During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10 (PubMed:12075009). It is also present between the microtubule manchette and the nucleus (PubMed:12075009). During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases (PubMed:12075009). In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots (PubMed:12075009). At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette (PubMed:12075009). In contrast, it is not present in mature spermatozoa (PubMed:12075009).
Protein: NEUG_MOUSE
Sequence: MDCCTESACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARKKIKSGECGRKGPGPGGPGGAGGARGGAGGGPSGD
What is the function of this protein?
Regulates the affinity of calmodulin for calcium.  Involved in synaptic plasticity and spatial learning.
What are the official names of this protein?
Neurogranin, Ng, RC3.
What is the protein family that this protein belongs to?
Belongs to the neurogranin family.
What are the subcellular locations of this protein?
Cytoplasm. Synapse. Cell projection, dendritic spine. Note=Restricted to dendritic spines of a subset of neurons.
Protein: RL27_CROS5
Sequence: MAHKKGTGSTRNGRDSRSQRLGVKRYGGQVVKAGNILIRQRGTKVHPGNNVGRGNDDTLFALIDGIVTFEYKTKSRRKVSVYPVAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: APAH_VIBPA
Sequence: MATYIVGDIQGCFDELQQLLKRVNFSTQHDQLWLAGDLVARGPKSLETLRFVKSLGDSAKVVLGNHDLHLLAVSYGLKKRKDKDKTTPIFLAKDREELLSWLAKQPLLAEHDEFVMCHAGISPQWDLETARQCAREVERIIQGEELPWLLKNMYSNLPDLWDDSLEGLDRYRYIINAFTRMRFCFSDGRLDMDCKLPPQEVTGDQLVPWFELPHRIPLEKTVLFGHWAALQGYIDEKVIGLDTGCVWGGSLTMIRWEDKQLFTQDALD
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: S12A9_MOUSE
Sequence: MASESSPLLAYRLLGEEGAAFPPNGAGVSGVPSSRKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYIILALTVLSVCAIATNGAVRGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESILDVFGADATGSSGIQVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLVSFVAVGPRNIPLAPRPGTNASSVPHRHGHFTGFNGSTLRDNLGAGYAEDYTTGAMMTFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIIAVAYTFFIYILLFFLSSFTCDRALLQEDYGFFRDISLWPPLVLIGIYATALSASMSSLIGASRILHALAQDDLFGVILAPAKVVSGGGNPWGAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLSALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKEHVKFWRPQLLLLVGNPRGALPLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDLAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPAEGTREGGSPALSTLFPPPRAPGSPRALSPQDYVATVADALKMNKNVVLARACGALPPERLSRGSSSSAQLHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILSMVPAWHSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAETGEPEEEEGDFVNGGRGDEEAEALACSANALVRAQQGRGTVGGPGGPEGRDGEEGPTTALTFLYLPRPPADPARYPRYLALLETLSRDLGPTLLIHGVTPVTCTDL
What is the function of this protein?
May be an inhibitor of SLC12A1.  Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (By similarity).
What are the official names of this protein?
Solute carrier family 12 member 9, Cation-chloride cotransporter-interacting protein 1, Potassium-chloride transporter 9.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THIM_DESVM
Sequence: MPHTEHIWRNVDAVRRQAPLVHSITNFVVMNVTANALLAAGASPIMAHAREEMAELVNIVSSLVLNIGTLSAPWIDSMFLAGAAAHERGIPVVLDPVGAGASTLRTTTAAQLMERVRPAIVRGNGSEIMALAGAAGATRGVDSTRDAHAAADSARALSRRHHCVTVVSGPVDLVTDGDEEVLITGGHELMPRVTGMGCTATVLVAAHAAVAASPLEGAVSGMAAMSAAGSMAAERAAGPGSFAMHFIDALYALSEADIRARVRVGRP
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: MNTH_STAEQ
Sequence: MGVILLNSNNNNHEQQRSLDEINNTINFNHNDSASQKFLAFLGPGLLVAVGYMDPGNWITSMQGGAQYGYTLLFIILISSLSAMLLQSMTVRLGIATGMDLAQMTRHFLNKPVAIMFWIIAELAIIATDIAEVIGSAIALDLIFGIPLIVGALITVFDVFLLLFIMKFGFRKIEAIVGTLIFTVLAIFVFEVYISSPQITDMLNGFVPHKEIITNQGILYIALGIIGATIMPHNLYLHSSIVQSRKYDRHSIHEKAQAIKYATIDSNIQLSIAFVVNCLLLTLGAALFFGTKTEDLGGFYDLYLALKTEPALGATLGGIMSTLFAVALLASGQNSTITGTLAGQIVMEGFLKLSIPNWLRRLITRSLAVIPVIICLIVFKGNTEKIEQLLVFSQVFLSIALPFSLIPLQLATSNQNLMGPFKNKTWINIISWLLIIVLSGLNVYLIIQTFQEL
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PURL_CERS5
Sequence: MTEPEITPELIAAHGLKPDEYERILGIIGREPSFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVICGPGENAGVVDIGDGQAVIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALSFGEPNHSKTAHIVKGVVEGIGGYGNAFGVPTVGGEVRFHRAYNGNCLVNAFAAGLADADKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVGDPFTEKRLLEACLELMASDSVISIQDMGAAGLTCSAVEMGDKGDLGIKLQLDNVPQREANMTAYEMMLSESQERMLMVLKPEKEAVARAIFEKWDLDFAIVGETIPEDRFLILHGNEVKADLPLKALSGTAPEYDRPWVETPAAAPMAPVAEVDPIEGLKALIGSPSYAHKAWVWEQYDSQVMADTVRAPGLGAGVVRVHGTPKALAFTSDVTPRYVKANPFEGGKQAVAEAYRNLTAVGAKPLATTDNMNFGNPEKPEIMGQFVGAIKGIGAAVAALDMPIVSGNVSLYNETDGVAILPTPTIGAVGILQSLDELIAGQPEEGDVALVIGETKGHLGQSALLAELLGREDGDAPHVDLDAEKRHGEFLRANRKLVSAATDLSDGGLALAAFEMAEGAGLGLTLTVTGTAQLFGEDQARYLVAVHPDQTKALQAAAEAAGVPLQQVGQFGGEEVTLGTVSAPLVDLSRLHRGAFAAAIG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4C_LOBMA
Sequence: MNDFPWLTIIVVFPISAGSLMLFLPHRGNKVNKWYTICISILELLLTTYAFCYNFKMDDPLIQLSEDYKWINFFDFYWRLGIDGLSIGTILLTGFITTLATLAAFPVTRNSRLFHFLMLAMYSGQIGLFSSRDLLLFFIMWELELIPVYLLLSMWGGKKRLYSATKFILYTAGSSIFLLIGVLGISLYGSNEPTLNLELLANQSYPVTLEILLYIGFLIAFAVKLPIIPFHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLVRINMELLPHAHSMFSPWLMVVGTIQIIYAASTSPGQRNLKKRIAYSSVSHMGFIIIGIGSITDPGLNGAILQIISHGFIGAALFFLAGTSYDRIRLGYLDEMGGMAISIPKIFTMFTILSMASLALPGMSGFVAELIVFFGIITSQKYFLISKILIIFVMAIGMILTPIYLLSMSRQMFYGYKLINVKNFSFFDSGPRELFLSISILLPIIGIGIYPDFVLSLASDKVESILSNYFYG
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.