PharMolix/UniProtQA huggingface dataset:
Protein: PIN4_TAEGU
Sequence: MAPKGKGGGKAGKGGDGGSSSEGKAQGPKGGGSAVKVRHILCEKHGRAMEAMEKLKSGQRFSEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSSMDKPVYTDPPVKTKFGYHIIMVEGRK
What is the function of this protein?
May be involved as a ribosomal RNA processing factor in ribosome biogenesis.  Binds to DNA (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, Parvulin-14, Par14, Peptidyl-prolyl cis-trans isomerase Pin4, PPIase Pin4, Rotamase Pin4.
What is the protein family that this protein belongs to?
Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.
Protein: TUSD_ENT38
Sequence: MRFALMVTGPAYGTQQASSALQFAQAVLAEGHELSSVFFYREGVYNANQFTSPASDEYDLVRGWQALNETQGVELHICVAAALRRGVADETEAKRLGLSGANLQHGFTLSGLGALAQAALTCDRMVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S2538_CHAGB
Sequence: MSDGSRTALSKSTFHFAAGLGSGVLSAVLLQPIDLLKTRVQQSGAHSLSAAIADIRAAPRLLPALWRGAVPSALRTGFGSAIYFTSLNAIRQSAARISPLPSSSSSTTTSSSTTTSSSSSSLPKLSNTSNLLAGAAARSLAGLILMPLTVLKVRYESTLYNYTSLASAARDIAAHEGARGFFAGYGATAVRDAPYAGLYVLFYEQGKKRLSQLFPTTTTTTTTNSTQNGPMGLQHAASINFASGVLAGVICSVVSNPFDAVKTRIQLQPGRYRNMVSGARRMVGEEGVRALWDGLALRMSRKAVSSALAWTVYEELIRRAEAGWRAGAARERL
What is the function of this protein?
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix.  Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
What are the official names of this protein?
Mitochondrial glycine transporter, Solute carrier family 25 member 38 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ISPG_RHILW
Sequence: MSPTADFDPKPRRASVAVDVGGVIVGGGAPVVVQSMTNTDTADIDSTVAQVAALHRAGSELVRITVDRDESAAAVPKIRERLLRLGMDVPLIGDFHYVGHKLLADHPDCAAALAKYRINPGNVGFKDKKDKQFAEIIEMAIRYDKPVRVGVNWGSLDQDLLTALMDENARAGSPLSARQVTREAIVQSALLSAALAEEIGLPRNRIILSAKVSQVQDLIAVNSMLAERSNHALHLGLTEAGMGTKGIVASSAAMGFVLQHGIGDTIRVSLTPEPNGDRTREVQVAQEILQVMGFRQFIPVVAACPGCGRTTSTVFQELAQNIQNDIRKNMPVWREKYPGVEALNVAVMGCIVNGPGESKHADIGISLPGTGETPAAPVFIDGKKALTLRGPNIAADFEALVVDYIEKRFGQRTAAE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: DTD2_LEIMA
Sequence: MLQAMDQGHLLVNNVDKYVRAGRGVMVYIAFLSDRDSAPITDEALRHAVGVLLHTKIFTHFSPEKMINQPQSLEECPEMDILIVPQASLGGKVKGRSVQFHQLVAKDVGAALYDRFCHFVRVARGVDESRVDANGAPRSEGDAPKAEGWIKYNSRVISGTFGNRQGLRFESEGPFTHMFDI
What is the function of this protein?
May hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr).  Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity).
What are the official names of this protein?
Putative D-tyrosyl-tRNA(Tyr) deacylase 2.
What is the protein family that this protein belongs to?
Belongs to the DTD family. Highly divergent.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAH_LEGPH
Sequence: MPDYAIGDVQGCYDPLQRLLELIDFNEKEDCLWFVGDLVNRGPDSLAVLRFIYSLPVKPKITLGNHDLHLLGLLFGGQPWKGHDDTLEEVMLADDGEELGHWLRKQSLLCRSSELNIVMCHAGIAPLWDLSKAMDLANELEAVLSGDSYHEFFAQMYGNKPDIWSDDLVGLDRLRVITNYFTRMRYCDAHGRLDLGYKGTLSKAPNHLYPWFEVPCRKEIEMDIVFGHWAALMGRSSHPRIHAIDTGCLWGGQLTALRLQDRQRFSVPGYGVSRFE
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: RS13_STRMU
Sequence: MARIAGVDIPNDKRVVVSLTYVYGIGLPTSKKILAAAGVSEDIRVKDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNTKNNARTRKGKAVAIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: HIS7_LEPBL
Sequence: MTRRLIRFYDPVRMKAERKTSETEIKLEMNLHGTGQYRFDTEIPFFEHMLSHISKHGLIDLNLWLRGDIEIDCHHSVEDTAILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLGGRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLHVFVHYGDNKHHVHESIFKALGKALRMAIAQDSATAGAIPSTKGVLE
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_ROSS1
Sequence: MPELPEVQLAADSLGVQIVGARIVRVERLDWTRMVETPSPDEFITLLAGRQVHGWGRRAKWILLFLDGGWTLALHLRMSGSLTVQPADAPPDKHTHLVLRLDDGRQVFFRDPRKFGRARLLDADGRAALDAAHGDEPLSNAFTVERLAELLRGRKRAIKPLLLDQAVIAGIGNIYADEALWRARIHPLRPASDLSADEVAALHDGIRAALRQALTNGGSTLRDYRNSYGTRGTNQDHFNAYDREGQPCPRCGATIIKTVVAQRGTHYCPECQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: Y1530_YERPA
Sequence: MSELCPCGSILNYHECCGPYILGTQVAAKPAILMRSRYCAYVEKNVDYLIATWHPDCHAQEWRESIIQGFTKTVWHGLTVIAETPGRHPDEAFVEFIARFTDADNAQITAMHERSRFLRIKEHWYYIDGIRPSLGRNDTCLCGSGKKHKKCCGR
What are the official names of this protein?
UPF0225 protein YPA_1530.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: TPB_RANDY
Sequence: MFTLKKSLLLLFFLGTINLSLCEEERDADEEERRDDPEERAVQVEKRILPILAPLIGGLLGK
What is the function of this protein?
Antimicrobial peptide.  Has low activity against the Gram-positive bacterium S. aureus (MIC>100 uM) and the Gram-negative bacterium E. coli (MIC>100 uM).  Has weak hemolytic activity against human erythrocytes.
What are the official names of this protein?
Temporin-CDYb.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: IDI1_YEAST
Sequence: MTADNNSMPHGAVSSYAKLVQNQTPEDILEEFPEIIPLQQRPNTRSSETSNDESGETCFSGHDEEQIKLMNENCIVLDWDDNAIGAGTKKVCHLMENIEKGLLHRAFSVFIFNEQGELLLQQRATEKITFPDLWTNTCCSHPLCIDDELGLKGKLDDKIKGAITAAVRKLDHELGIPEDETKTRGKFHFLNRIHYMAPSNEPWGEHEIDYILFYKINAKENLTVNPNVNEVRDFKWVSPNDLKTMFADPSYKFTPWFKIICENYLFNWWEQLDDLSEVENDRQIHRML
What is the function of this protein?
Isopentenyl-diphosphate delta-isomerase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:2223785, PubMed:2681212, PubMed:7908830).  IDI1 catalyzes the 1,3-allylic rearrangement of isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (PubMed:2223785, PubMed:2681212, PubMed:7908830).  The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.  Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate.  5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8.  The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate.  The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).  Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, Isopentenyl pyrophosphate isomerase, IPP isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KXDL1_XENTR
Sequence: MAEQVTEATASGVFCSRILNMVNSEDVNAIILAQRHMLDRFEKTNEMLLNFNGLSNTRLQQMSDRFAHHTRTLVEMKKDLDIIFRRIRMLKGKLAKQYPESFNNVHESPILEDDDDFDPTPRSAATTIATSEQSTESCDTSPSIISPAMSQDFEDLSQAPSDTPSVNGQILTDEEVVHED
What is the function of this protein?
As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery.  Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.  May also be involved in the biogenesis of lysosome-related organelles such as melanosomes.
What are the official names of this protein?
KxDL motif-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the KXD1 family.
What are the subcellular locations of this protein?
Lysosome membrane.
Protein: VKT35_CYRHA
Sequence: MGTARFLRAVLLLSVLLMVTFPALLSAEHHDGRVDICRLPSDSGECSRFFGMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Dual-function toxin that inhibits both serine proteases (trypsin) and voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hhn1d, U15-TRTX-Hhn1d, Kunitz-type serine protease inhibitor HNTX-031496134.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 03 (sub-Kunitz) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CP17A_MESAU
Sequence: MWELVALLLLTLAYFFWSKSKTCGAKSPKSLPFLPLVGSLPFIPRHGHPHVNFFKLQEKYGPIYSLRLGSTTTVIIGQYQLAKEVLVKKGKEFSGRPHMVTLGLLSDQGKGIAFADSGGSWQLHRKLALSSFALFRDGNQKLEKIICQKASSLCDFLLTHNEESIDLSEPIFNSITNIICIICFGISYENRDPILATIKSFTEGILNSLGNDHLVDIFPWLTIFPNKTVDMIKKNVKIRDEVLSGILEKCKEKFNSDSISSLMDLLIQAKTNADNNNTSEGQGSNAFSDMHILATIADIFGAGIETTASVLSWIIAFLLHNPEVKKKIQKEIDQNIGFSRTPTFNDRNHLLMLEATIREVLRIRPVAPMLIPHRANSDMSIGEFSIPKFTPVIINLWALHHSEKEWDQPDRFMPERFLDPTGSHLITPSLSYLPFGAGARSCIGEVLARQELFLFMAHLLQRFDLDVPDDEQPPCLKGNANVVFLIDPFKVKITVRQAWKDAQAEVNTWRP
What is the function of this protein?
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis.  Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways.  A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage.  The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol.  Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione.  Has 16-alpha hydroxylase activity.  Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA.  Also 16-alpha hydroxylates androgens, relevant for estriol synthesis.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Microsome membrane.
Protein: DNAK_MYCPU
Sequence: MAKEIILGIDLGTTNSVVSIIENKKPVVLENFNGKRTTPSVVAFKNGEIQVGEIAKRQLETNPDTIASIKRLMGTTKTVKANGKTYKPEEISAMILSHLKEYAEKKVGKKLTKAVITVPAYFDNSQREATKIAGKIAGLDVLRIINEPTAAALSFGLDKKEKEMKVLVYDLGGGTFDVSVLELENGTFEVLSTSGDNHLGGDDWDHVIVEWLTKEIKNRYDFDPSKDKMVMTRLKEAAEKAKIDLSAQMVAQITLPFLSVTSKGPINVDLELKRSEFEKMTTHLVDRTRKPIEDALREAKIKASDLSEVLLVGGSTRIPAVQSMVEHVLGKKPNRSINPDEVVAIGAAIQGGVLAGDINDVLLLDVTPLTLGIETLGGVATPLIPRNTTIPVTKSQVFSTAADNQSEVTISVVQGERPMASDNKQLGQFNLSGIEPAPRGVPQIEVSFSIDVNGITTVKAKDLKTNKEQEITIKNSSKLSDEEVEKMVKEAEENREADKAKKEKVEVIVRAESLISQLEKSLVDQGDKVDAKAKEETQKQIQELKDLIKDDKIEELKVKLEQIEQAAQAFAQYSAQQAATENSKDSDTVEAEIVDDKAN
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ENV_HV190
Sequence: METQRNYPSLWRWGTLILGMLLICSAAQNLWVTVYYGVPVWKEAKTTLFCASDAKAYETEKHNVWATHACVPTDPNPQEMVMENVTESFNMWENNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLNCTNVRNNTSNSTSSMEAGGELTNCSFNVTTVLRDKQQKVHALFYRLDVVPIDNNSTQYRLINCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGLCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEQIIIRTKNISDNTKNIIVQLKTPVNITCTRPNNNTRTSIHLGPGRAFYATGDIIGDIRQAHCNISRTDWNKTLHQVVTQLGIHLNNRTISFKPNSGGDMEVRTHSFNCRGEFFYCNTSGLFNSSWEMHTNYTSNDTKGNENITLPCRIKQIVNMWQRVGRAMYAPPIQGNIMCVSNITGLILTIDEGNASAENYTFRPGGGDMRDNWRSELYKYKVVKIEPLGIAPTKTRRRVVEREKRAVGMGASFLGFLGAAGSTMGAASITLTVQARQLLSGIVQQQSNLLRAIQARQHMLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTNVPWNSSWSNKSQSEIWDNMTWMEWDKQISNYTEEIYRLLEVSQTQQEKNEQDLLALDKWASLWTWFDISHWLWYIKIFIMIVGGLIGLRIIFAVLSIVNRVRQGYSPLSFQTLVPNPRGPDRPEGTEEGGGEQDRDRSVRLVNGFLPVVWDDLRSLSLFSYRLLRDLLLIVVRTVELLGRRGREALKYLWNLLQYWGQELKNSAIDLLNTTAIAVAEGTDGIIVIVQRAWRAILHIPRRIRQGFERSLL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: B2MG_TRIVU
Sequence: MMARIFILALLGQLCFLPYLDAITSSPKVQVYSRHPVDSNKENFVNCFVSGFHPPQITIELSKDGEKIPKVEESDLSFSNDWTFNRLVSAPFDPNSRSEYTCKVTHLTLQEPKVVKWDPENN
What is the function of this protein?
Component of the class I major histocompatibility complex (MHC).  Involved in the presentation of peptide antigens to the immune system (By similarity).
What are the official names of this protein?
Beta-2-microglobulin.
What is the protein family that this protein belongs to?
Belongs to the beta-2-microglobulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ROGF4_ARATH
Sequence: MESSSNSDQNEGTPTSSVSSPYRRTYSDISGLSHRFDVQSFYNRPSNTNAVVLSGHEEDVSEDAEEPKDDVVNDVHGDGDEEDSDIDSAEDAELEMMRERFAKLLLGEDMSGSGKGVCTAVTVSNSITNLYATVFGQSLRLQPLSTEKKDLWKREMNCFMSICDYIVEVIPRSLGTNVEITETKLRSDILMSLPALRKLDNMLMEILDSFTENEFWYVERGSSSMNSGGGGRDSGTFRKVVVQRKDEKWWLPVPCVPAEGLSEEERKHLRHKRDCASQIHKAALAINDSTLNDMDIPDSYLTTLPKSGKASVGDVIYKQLCTAEKFYPDQLLDILKITSEHEALELADKVEASLVTWRRKTGGLTHSKSSWDMMKDISGDADRGNDKNHILAARARSLLFCLKQRYPELSQTSLDICKIQFNRDVGKAVLESYSRVLEGLAYNVVSWIDDVLYVDRTVRNRDD
What is the function of this protein?
Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP.  In association with ROPGEF1, acts as specific regulator of ARAC10/ROP11 function in ABA-mediated stomatal closure.
What are the official names of this protein?
Rop guanine nucleotide exchange factor 4, AtRopGEF4, Rho of plants guanine nucleotide exchange factor 4.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Interacts with ARAC10/ROP11 on plasma membrane in guard cells.
Protein: TRY3_CANAL
Sequence: MKFAKTLERTLEEDEIPQEWVEAAIQYKALKKCINKVVNELEFLGLQKNTLKILLNDKVVEVNEQETNPSNPIIAEYILSKTSTDAHNIKPMLKITLDYSSEDYTKDHIVELGKELKQKIEALLNDSDTEYEEDKIIELKEDDGGDLQIVTSREGSLSPPASRMASPPTSPTLKVVDSLNTNIDEALLSPDDHHKKHEIFIMLNSDSKFFEMLNDELNSLDTLTQQEESKIIEEVKKIAKYVNELKLKQSELYKWRELFKVYLDSEVYFKYNETALPSQQKSSEQIKSNLDLFVTNLNKSGIMTRFKKKQSLETFNQFMEMNYHLLKILQFQTINNEALRKILKKFDKQTSLGIQKTFPKLISNDHIFMSGSSLAQSICYIIQESIIKVIPQLDDYSCPICMNIAYKPIRLSCGHLFCVRCLVKMKQDDKTSCPLCRKENAILYADSSNLDLESMELMKKYFPREVKEKLRERDKERYNELRKNANSGEKCIVM
What is the function of this protein?
Transcription factor required for yeast cell adherence to silicone substrate.
What are the official names of this protein?
Transcriptional regulator of yeast form adherence 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: GPMI_SALPB
Sequence: MSVSKKPMVLVILDGYGYREEQQDNAILNAKTPVMDALWAKRPHTLIDASGLEVGLPDRQMGNSEVGHVNLGAGRIVYQDLTRLDVEIKERTFFANPVLTNAVDQAKNAGKAVHIMGLLSAGGVHSHEDHIMAMVELAAERGAEKIYLHAFLDGRDTPPRSAEASLKKFEDKFAALGKGRVASIVGRYYAMDRDNRWDRVEKAYDLMTLAQGEFQADTAVAGLQAAYARDENDEFVKATVILAEGQADAAMEDGDTLIFMNFRADRAREITRAFVNADFDGFARKKVVNLNFVMLTEYAADIKTAVAYPPASLVNTFGEWMAKNDKTQLRISETEKYAHVTFFFNGGVEEPFAGEERILINSPKVATYDLQPEMSSAELTEKLVAAIESGKYDTIICNYPNGDMVGHTGVMEAAIKAVEALDNCIEQVTKAVESVGGQLLITADHGNAEQMRDPATGQAHTAHTNLPVPLIYVGEKNVKAVEGGKLSDIAPTMLSLMGMEIPQEMTGKPLFIVE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: DCXR_MOUSE
Sequence: MDLGLAGRRALVTGAGKGIGRSTVLALKAAGAQVVAVSRTREDLDDLVRECPGVEPVCVDLADWEATEQALSNVGPVDLLVNNAAVALLQPFLEVTKEACDTSFNVNLRAVIQVSQIVAKGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALDMLTKMMALELGPHKIRVNAVNPTVVMTPMGRTNWSDPHKAKAMLDRIPLGKFAEVENVVDTILFLLSNRSGMTTGSTLPVDGGFLAT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose.  Participates in the uronate cycle of glucose metabolism.  May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
What are the official names of this protein?
L-xylulose reductase, XR, Dicarbonyl/L-xylulose reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Apical cell membrane; Peripheral membrane protein. Note=Probably recruited to membranes via an interaction with phosphatidylinositol (By similarity). In kidney, it is localized in the brush border membranes of proximal tubular cells.
Protein: EF1A_THEGJ
Sequence: MAKEKPHVNIVFIGHVDHGKSTTIGRLLFDTANIPENIIKKFEEMGEKGKSFKFAWVMDRLKEERERGITIDVAHTKFETPHRYITIIDAPGHRDFVKNMITGASQADAAVLVVAATDGVMPQTKEHAFLARTLGINHIIVAINKMDMVNYDQKVFEKVKAQVEKLLKMLGYKDFPVIPISAWEGDNVVKKSDKMPWYKGPTLIEALDQIPEPPKPIDKPLRIPIQDVYSIKGVGTVPVGRVETGVLRVGDVVIFEPASTIFHKPIQGEVKSIEMHHEPLQEAYPGDNIGFNVRGVGKNDIKRGDVAGHTTNPPTVVRPKDTFKAQIIVLNHPTAITVGYTPVLHAHTTQVAVRFEQLLAKLDPRTGNIVEENPQFIKTGDSAIVILRPTKAMVIEPVKEIPQMGRFAIRDMGQTVAAGMVISIQKAE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha, Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_SYNWW
Sequence: MARRTTTRVKRREKKNIEHGIAHIKSTFNNTIISITDRHGNAISWSSAGTIGFKGSRKSTPFAAQQAAENAAKAAMEHGLKEVECYVKGPGAGREAAIRSLQAAGLEVSVIKDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RS6_DESHD
Sequence: MKAYEVLYVIRPDLDDEAVAATVDKLSEVVTNNGGADVAIDKWGKRRLAYEVNDYREGFYILMNFNGEARTAQEVERIMKISDAVVRFLTTKKED
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RNFH_SALHS
Sequence: MPDKLVVEVAYALPEKQYLQRVTLEEGATVEEAIRASGLLELRTDIDLAKNKVGIYSRPVKLTDTVQDGDRVEIYRPLIADPKALRRQRAEKSAGR
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.