PharMolix/UniProtQA huggingface dataset:
Protein: DKK2_HUMAN
Sequence: MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI
What is the function of this protein?
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6.  DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.  In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
What are the official names of this protein?
Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2.
What is the protein family that this protein belongs to?
Belongs to the dickkopf family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL11_CHLRE
Sequence: MREIRISKLVLNIAVAESGDRLQKAAKVLEQLTSQVPVYGRARFTVRSFAIRRNEKISCYVTVRGEKAYDLVKRGLAVKEFELIRKNFSDTGNFGFGIQEHIDLGLKYDPSTGIYGMDFYVCLERRGYRVARRRKQKAHVGVKHKVTKEDAIKWFQQEFDGVVLNKAPAS
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MFSD5_XENTR
Sequence: MLLTAYFVLVGLIALWAVLEFSACHSKPSTSSNAVGNPAFRQFQYDFYRTYFPALAADWLQGPYLYKLYQHYHFLEGQIAIIYVCGFGASVFAGLVSAPLTSRLGRRKSCILFCLLLSASYLCKLSQEYFVLITGRVLGGFSSSLLFSSFEAWYTHEHAEQHDFPAEWLPHTFTRAAAWNGGIAIAAGVIANACAEWLGLGPASPSVLAVPLLVLSVALVIREWDENYGQTSSFRRVCGDGLRCLLRDRRVLLLGTIQALFESVVYIFIFLWTPVLDPHNTPLGIAFSSFMAASAAGSSLYRLATSKKYHLQPMHVLCLSILMVFFSLFMLTFSTAPGQEHPTESLLAFLLIELACGLYFPAMGFLRCRLIPEKEQIGVLNWFRVPLNLLAGLGLLVLHDSDYQSGTRNMFSLCAITMLLALLCVVSLFTMVRNDSELRLPTSETEPNGTEQ
What is the function of this protein?
Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
What are the official names of this protein?
Molybdate-anion transporter, Major facilitator superfamily domain-containing protein 5, Molybdate transporter 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CLC1_SCHPO
Sequence: MSQFPALEDFDDGLVTAPVDDSKNNTDFLEREKLALGEDAGQFETPEDKDALLNFENDSEAEQTRFEQNFPPIDAEMQASGTFSAPKAPYMGQAEVHPPEDESGDPEPVRKWKEDQMKRIQERDESSKKLRESNIEKARKAIDDFYENFNDKRDKVIAKSRKEQEKLLEENESKSTGTTSWERILKLIDLSDKPEAHGRSTERFRELLISLAKDSNAPGAAGTTVSSSS
What is the function of this protein?
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
What are the official names of this protein?
Clathrin light chain, CLC.
What is the protein family that this protein belongs to?
Belongs to the clathrin light chain family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Protein: SSRP_METC4
Sequence: MAPKPDPGRRVVADNRSARYHYAIEDTLEAGIALTGTEVKSLRGGKATIGESYAGPSGNDLMLFNAYIPEYLEANRFNHDTKRPRRLLLHRRQINKLIGATQRQGYTVIPLKIYFNDKGRAKVELGLGKGKQLHDKRESVKQRDWDRDKARLMRDKG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PJA2_MOUSE
Sequence: MSQYTEKEPSVMDQESSKAAWPKPAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAGDDYEVLELDDVPKENTSGSSSLDQVHPALPNEPTVEKSETEISTCGPALNQSTESSPSIATVCHSEEVRETLESNTNLHNRTETEHTPAVCNVSSVQNGIMLVHTDSYDPDSKHDENGSLQLGAEAVEGGRHQKGLGRAVFELENGEAEIYADLSPSVPSLNGEISEAFEELDSAPLEKSSTADAELVHQNGQEFQRSSEDGVVRKRRQDDTDQGRQTENSTEDADCAPGHVEQNTSDRANHHGSSPEQVVRPKVRKVISSSQVDQEIGFNRHEAKQRSVQRWREALEVEECSSDDPIIKCDDYDGDHDCMFLTPTYSRVTQRETERNRVTSENGATASGRQESRDNAFWNACGEYYQLFDKDEDSSECSDGEWSASLPHRFSGTEKDQSSSDDSWETLPGKDENDPELQSDSSGPEEENQELSLQEGEQTSLEEGEIPWLQYNEVNESSSDEGNEPANEFAQPEAFMLDGNNNLEDDSSVSEDLDVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWLQKSGTCPVCRRHFPPAVIDASAAASSDPDPDASPANDNAEEAP
What is the function of this protein?
Has E2-dependent E3 ubiquitin-protein ligase activity.  Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation.  Essential for PKA-mediated long-term memory processes.  Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.  Plays a role in ciliogenesis by ubiquitinating OFD1.
What are the official names of this protein?
E3 ubiquitin-protein ligase Praja-2, Praja2, RING finger protein 131, RING-type E3 ubiquitin transferase Praja-2.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Synapse. Postsynaptic density. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses. Co-localizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (By similarity).
Protein: DCDA_HELPY
Sequence: MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHLESGADCVSIGEIYRALKAGIKPYRIVFSGVGKSGFEIEQALKLNILFLNVESFMELTTIETIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVGEKEALEMFLWAKKSAFLEPVSVHFHIGSQLSDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYDYAQGILNSLQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVVVDAGMNDFLRPSLYHAKHAIRVITPSKGREISPCDVVGPVCESSDTFLKDAHLPELEPGDKLVIEKVGAYGSSMASQYNSRPKLLELALEDHKIRVIRKREALEDLWRLEEEGLKGV
What is the function of this protein?
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
What are the official names of this protein?
Diaminopimelate decarboxylase, DAP decarboxylase, DAPDC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
Protein: HHO2_ARATH
Sequence: MMVEMDYAKKMQKCHEYVEALEEEQKKIQVFQRELPLCLELVTQAIEACRKELSGTTTTTSEQCSEQTTSVCGGPVFEEFIPIKKISSLCEEVQEEEEEDGEHESSPELVNNKKSDWLRSVQLWNHSPDLNPKEERVAKKAKVVEVKPKSGAFQPFQKRVLETDLQPAVKVASSMPATTTSSTTETCGGKSDLIKAGDEERRIEQQQSQSHTHRKQRRCWSPELHRRFLNALQQLGGSHVATPKQIRDHMKVDGLTNDEVKSHLQKYRLHTRRPAATSVAAQSTGNQQQPQFVVVGGIWVPSSQDFPPPSDVANKGGVYAPVAVAQSPKRSLERSCNSPAASSSTNTNTSTPVS
What is the function of this protein?
Probable transcription factor involved in phosphate homeostasis.  Involved in the regulation of the developmental response of lateral roots, acquisition and/or mobilization of phosphate and expression of a subset of genes involved in phosphate sensing and signaling pathway.  Is a target of the transcription factor PHR1.
What are the official names of this protein?
Transcription factor HHO2, MYB-domain transcription factor HHO2, Protein HRS1 HOMOLOG 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: KIF24_MOUSE
Sequence: MASWLYECLCEAELAQYYPHFTALGLQKIDELAKVTMKDYSRLGVHDMNDRKRLFQLIKIIKIMQEEDKALGIPEHPLQASSLYTKPREFRSGPRRQLHFDSPSASKDKMANNETGSLSNFSVDEQKSTYLKVLEHMLPDDSQCQTKIRAPDASAADASMQTETNAPLFSSNYFSPQLGNCDIPVIQRVSHVSGYNYGIPHSCVRQITSENPWTEMEKIRVCVRKRPLGVREVRRGEVNVITVEDKETLLVHEKKEAVDLTQYILQHVFYFDEVFGEACSNQDVYLKTAHPLIQHIFNGGSATCFAYGQTGAGKTYTMIGTHQNPGLYALAAKDIFRQLKVSQSRRNLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHVVQIAGLRELQVDSVELLLQVILKGSKERSTGATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHIATEHTLNTLRYADRVKELKKGVKCCASATSQNQTSANASPKRIQSSPVTLPGDKCSPKKVKLGLQQSLTVAPGPTKVKAHPLASHVPNVPFTSGPKTPGKKSSSRGSPTPEWDMKASPRKGTTRSGHSIKKGAESAPLCSEKSQIGSKIAVGWEGRASDPGEGLLRVRLPTRGKKVQPVQPVQKQLLSRPRLLANSHHLEATQDSKVGTPAGLAPEAWTNPILQQKEREEHLRFYHQQFQQPPLLKQKLNYQPLQRLLCQHRPSEGRLQSETGFPLHSNPENRDGAQAEDLDDSDFSEDSFSHGSSQPAMKQGSTALERSGSSFFLHQDREHSPEEQAAERQQCLLFSSETDGSKKRPADSWVYSRDPIISHRRGALSQSHSPSMVCPDWSKEEDSASSGPSPKDNRAQKPSSSQVDFVHHQKPGEAQVSDIRLEAFTSEVPEQAEGSLSSPSPENGLSFPLSHVAVSGSPDQRDRVCTPLREVSENRVTHTPGRVNSSTPFQEDSGEQIQMCSANASGLMAPLTMSLLETPCHEDLSSLEQIAQDGAGYGFMAEIVGGPAAGHTVPSYDQEAALPVSSATECLWLSSSPPDNRPSGDLPALSPSPIHQHSPDKLPGREAYQTRRPILLPENHMGSKLYDDRAEETELGGSLTFPRKPSSNIHAGVPYSTPFLTSCTGSSNGVGRPWAQERKHPTGVSCQELVSSTDSNKPHYNEDIAWLRHRPISRCLDSDSPVVPSCSSKALRTYCPLTPEQAQQVIIRAHKEQLDEMAELDLKEETLMTQMDSNDFEDFVTQLDEIMALKSRCIQSLRSQLQLYLTSHRPAAAPERTVVS
What is the function of this protein?
Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles.  Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.  Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes.  As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (By similarity).  Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (By similarity).
What are the official names of this protein?
Kinesin-like protein KIF24.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.
Protein: LEU3_MYCA1
Sequence: MKLAVIGGDGIGPEVTAEALKVLDAVLPGVDKTEYDLGARRYHATGELLPDSVIDELRAHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPGRLYPGVSSPLAGNPDIDFVVVREGTEGPYTGTGGAIRVGTPNEVATEVSQNTAFGVRRVVVDAFERARRRRKHLTLVHKTNVLTFAGKLWSRIVAEVGRDYPDVEVAYQHIDAATIFMVTDPGRFDVIVTDNLFGDIITDLSAAVCGGIGLAASGNIDGTRTNPSMFEPVHGSAPDIAGQGVADPTAAIMSVALLLAHLGEDAAATRVDRAVERYLATRGNERPATTEVGERIAAAL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3604L_ASFP4
Sequence: MNSLQVLTKKVLIENKAFSNYHEDDIFILQQLGLWWHNGPIGFCKQCKMVTSGSMSCSDVDSYELDRALVRAVKKNQTDLIKLFVLWGANINYGIICAKTERTKVLCIQLGADPKFLDVGLYNLFVDLIKQQKVLLAIDIYYDNISILDRFDSHDFYVLIDFIYNCFILNLDEKEKMIKNTYVLKFWFKIAIEFNLIKPIRFLSKKFPHLDDWRLKTAVYLGNVDEIHHAYFQENIRLDPNDMMPLACMYPQNKLGIYYCFALGANINTALETLIRYINHEVNGEITFFSNYGIWSNVHFCISLGANPYTKKIQETLLRQEKNVIMKLLFRKGLLSPHSILHKKILEPSEVRKIISTYEYTETFHSFSLLRDNLR
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-4L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: DCD_ECOHS
Sequence: MRLCDRDIEAWLDEGRLSINPRPPVERINGATVDVRLGNKFRTFRGHTAAFIDLSGPKDEVSAALDRVMSDEIVLDEGEAFYLHPGELALAVTLESVTLPADLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNRREDAKYRNQQGAVASRIDKD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: FIZ1_HUMAN
Sequence: MDDVPAPTPAPAPPAAAAPRVPFHCSECGKSFRYRSDLRRHFARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLHHQVVHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGVLPSPLQPGPGLPALSAPCSVCCNVGPCSVCGGSGAGGGEGPEGAGAGLGSWGLAEAAAAAAASLPPFACGACARRFDHGRELAAHWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGPGAPPAQAWAAGPGAGPETAGEGTAAEAGDAPLASDRRLLLGPAGGGVPKLGGLLPEGGGEAPAPAAAAEPSEDTLYQCDCGTFFASAAALASHLEAHSGPATYGCGHCGALYAALAALEEHRRVSHGEGGGEEAATAAREREPASGEPPSGSGRGKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLECGKFFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLKLHRGMD
What is the function of this protein?
May be a transcriptional repressor of NRL function in photoreceptors.  Does not repress CRX-mediated transactivation (By similarity).
What are the official names of this protein?
Flt3-interacting zinc finger protein 1, Zinc finger protein 798.
Protein: GLNE_YERPB
Sequence: MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: RL2_PSELT
Sequence: MGLRKYKPATPGVRFMIRNDFSGLTKKEPEKSLLVPLKKTGGRNHYGRITVRFRGGGHKRQYRLIDFKRDKIGIPAKVSAIEYDPNRSARIALLVYADGEKRYILAPNGLQVGDTVLSGIDAEIRVGNALPLENIPLGTLLHNVEIRPGSGGKIARSAGVSCQLMAKEGNYALLRMPSGELRKVHIKCYATIGVVGNEDHKNEVFGKAGRTRWIGRKPHVRGMVMNPVDHPMGGGEGRGKGQHPVTPWGMPTKGYKTRRGRRASDKFIVRRRNQV
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RL31_ONYPE
Sequence: MKANIHPQFETVEVSCATCGKQHPIGTTVTSIKIETCSNCHPFYTGAQTFVVKAGPVDKFNKRYGITQDQKVKTVSSNADNQKETTEELIKNK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RUVA_RALPJ
Sequence: MIGRIAGTLIEKNPPHLLVDCHGVGYEIDVPMSTFYNLPATGEKVVLLTQQIVREDAHLLYGFGTAAERETFRQLIKISGIGARIALAVLSGMSVAELAQAVTLQEAGRLTRIPGIGKKTAERLLLELKGKLGADLGTVPGGPAVSDDAVDVLNALLALGYSDKEAALAIKQVPAGTGVSEGIKLALKALSKG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: LSRF_YERPY
Sequence: MADLDDIKDGKDFGIGIPQQNPAFTLKGSGSLDWGMQSRLARIFNPKTNRTVMLAFDHGYFQGPTTGLERIDINIAPLFEYADVLMCTRGILRSVVPAAANRPVVLRASGANSILTDLSNEAVAVAMEDAVRLNACAVAAQVYIGTEHEHQSIKNIIQLIDQGMRYGMPTMAVTGVGKDMVRDQRYFSLASRIAAEMGAQVIKTYYVDSGFERIAAGCPVPIVIAGGKKLPERDALEMCYQAIDQGASGVDMGRNIFQSDAPIAMLKAVHAIVHKNENAAAAYQLFLHEQN
What is the function of this protein?
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.  Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
What are the official names of this protein?
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNT8_HUMAN
Sequence: MEFLERTYLVNDKAAKMYAFTLESVELQQKPVNKDQCPRERPEELESGGMYHCHSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQRCLGHNHKEVQANASVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPDCLFCEDPCD
What is the function of this protein?
Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion.
What are the official names of this protein?
Proton-coupled zinc antiporter SLC30A8, Solute carrier family 30 member 8, Zinc transporter 8, ZnT-8.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Note=Associated with insulin and glucagon secretory granules.
Protein: PFA4_CANGA
Sequence: MPVKLKWPWLGIAIPSFLIASIGYCAHYFILLNFLSLRKQLWYQFCQTMIWLSYYLAIYTPPGKPPTNFKPSKNEWKVYCKKCKCYKPERSHHCKTCNQCVLMMDHHCPWTMNCVGYNNFPHFIRFLFWVIVGTTSLAIFLTTRIHSIWVHRSSPSYLYYKSELIFLTILTPLNAFILLTISILMIRCLFNQIFNGRSQIESWEMDRLETLARMSKLLPILIENVWYIFPNLRNEHVESQAEALLNKKRLSLDELVNFPYDLGPFRNAIQLLGTPPLWLYPFSGPQDDGLHFQKNEESMIEDPNSLNDIILCLPWPPDSTKHLNSTSEHTSNVQIISEEGEQVIRIRTPEKKLSRSEWLNDWGESLEDFGVDVDVE
What is the function of this protein?
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
What are the official names of this protein?
Palmitoyltransferase PFA4, Protein S-acyltransferase, PAT, Protein fatty acyltransferase 4.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: C3H11_ORYSJ
Sequence: MPPKKAAPSKADLAKKQKVVEDKTFGLKNKNKSKNVQKYVQSLHQAVQPKPDPTKTAAKKKKEEEKAREKELNDLFKVAVSQPKVPVGVDPKSIVCEFFKVGQCQKGFKCKFSHDLNVQRKGEKIDIYTDKRDAETMEDWDQETLEKVVASKGAEYQQNKPTDIVCKYFLDAVEKKQYGWFWVCPNGGKDCHYRHALPPGYVLKSQMKALLEEESEKIAIEDEIEDQRKKVKTTTPMTTDLFMEWKRKKAEEREAGLAALRAERAKNDRMSGRELFMADSSVFVDDAEAYDVYERQEESEANEEPSNKNQDEGPSSSTSNGKEVEESDDEDINIDDDLDIDELNELEASLSRTSIQIREPGEGTSS
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 11, OsC3H11.
Protein: SYD_STRTD
Sequence: MERSMYAGRVRSEHIGTTITLKGWVSRRRNLGGLIFIDLRDREGLMQLVVNPENTDAAVVETAESLRSEFVIEVTGTVEAREQANDNLPTGAVELKVEDLKVLNTAKTTPFEIKDGVEASDDTRMRYRYLDLRRPEMLENFKLRAKVTHTIRNYLDDLEFIDVETPMLTKSTPEGARDYLVPSRVSQGHFYALPQSPQITKQLLMNAGFDRYYQIVKCFRDEDLRGDRQPEFTQVDLETSFLNEQEIQDITEGLIAKVMKETKGVEVTLPFPRMSYDDAMNNYGSDKPDTRFDMLLQDLTELVKDVDFKVFAEAPAVKAIVVKGNADKYSRKSIDKLTDFAKQFGAKGLAWVKMTDGVLAGPVAKFLTSIEEKLTDALQIEENDLVLFVADTLEIANNTLGALRNQIAKELDMIDNTKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPTEDSAAELEGDLSKVRAVAYDIVLNGYELGGGSLRINQKDLQERMLKALGFSEESAYEQFGFLLEAMDYGFPPHGGLALGLDRFVMLLAGKDNIREVIAFPKNNKASDPMTQAPSLVADKQLEELALHVELENE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA23_ACASS
Sequence: NLLQFAFMIRQANKRRRPVIPYEEYGLYYM
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that has myotoxic activity but no significant neurotoxicity.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 acanmyotoxin-3, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily.
What are the subcellular locations of this protein?
Secreted.