Protein: DPY27_CAEEL
Sequence: MQPFKRRALTSDDDRPYADTDSMPEVDLDVDRRRQYMEQLNIFDDVSSGAYMLELEAAENGVKYDEKEDLLNVQIPPKYEDQISDPDGNRMIILNIYVENFKSYAGKHILGPFHKNLTMILGPNGSGKSNVIDALLFVFGFKAGKIRTKKLSALINSGGNYESCSVTIMFQMVKDMPVENYDKYEVLTDNCVCITRTINRENNSKYRIDDKDASQKDVQELLLRAGIDMTHNRFLILQGEVEAIALMKPTSKNPNEEGMLEYIEDIVGTNRFVAPISKLMHRVSLLEHKSSQYGASVRRHEGHLKVFEKAMVIGMAYLNTFNNLNYLRGIRVKHNLCRYAETMRDAKMSLVTRTGELEENKDIMLEAKDEVRKKETHERSLNSIVTELENKRIDWQSKKNDWHARDAKRKQGLKSCTQDLGKLMKERDEARREKFEIETAPENARISKQNMQLEWDQLKEQENVCQRTATENLIKYDQKSSADRAKHDDLEKKLSDELLQSMRAKAELDVSESELKDMTIMMEQGQKRVDELKGTLQTMMAENIRDNTELNAVTTELQDRKLKFDKAVEKLPHLKSTEQLLRSKKYELDQEVIEASNTQEVTYRHQATAKLHELKEAGLFPGFKGRLGDLASIPIKFDTAISTVFFAQLDYHVVQTSDECRIGIGFCHEYKLPRTTFVFLDHLKDTDTSGMDSTMKFPAERLFDKIHCVNPEIRREFYFLIHDILVVDSLEEATRIDKKYPGRHRYCTLNGSILNRSGALTGGGKPTTGRIRNDNNPNMSGVKKVDLSKLRAAQEKHNHALEAHLKLQLKQEEIRADNGPIIKQLEIRKRELIMSTKEQKTRIAELKSSIAAHERRMVNYREVTVEDLDEKRAQIADLKRQVEESQKSSAKIKQQIEQYKRKMDRMFMELVQKNKDSIEQAKDRMGQLEQDIARQTAIIENNPSHLEQAEKKLSELEHMCLEKRSEADALAQLEVGEDVKGIDIINAQLQTSTASIDAQRARYTEAVAARREADAAYQTTVDNYNMVKQTYDELMRIIDDLENKTMADNAELDIIESAWMQPEKLYPPGKFVRYNDPDIAAKMTDGHVVLPYECISMIEPHREAYEEHEARMLEDDVFEDTANKICKLEKDVDKFRREFDNKGVRDYAMIVSLLMNEVTSAKKFSDKLKAHREKLNELRMARFNEFSEALAFLGTTTQMLYQLITNGGDASLKFVEEGKSTDPFDGGIKFSVRPAKKSWKLIENLSGGEKTLASLCFVFAMHHYRPTPLYVMDEIDAALDLNNVSLIANYIKHSERTRNAQFIIISLRNQMFEVGNRLLGIYKIDGKTYNIMVDPIAVEIKNRPILKIFEEEIKRREKLRRAEIEPEIDLSNGLSNVVIAPKRKQRRLEMLKLSDFGLDDDSDLPEFNRFPPATRRELSVEDSDEDDEPVRRRPRRQVEEEDEEDELIEEATPSPPPIVVQRRVRRSRH
What is the function of this protein?
Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development (PubMed:7954812, PubMed:3779843, PubMed:26641248, PubMed:8939870, PubMed:14660541, PubMed:22393255, PubMed:19119011).  Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase (PubMed:8939870).  Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome (PubMed:14660541, PubMed:9458050).  Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on dosage compensated X chromosomes (PubMed:22393255).  As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites (PubMed:11937488).  Also plays a role in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway (PubMed:23884442).
What are the official names of this protein?
Chromosome condensation protein dpy-27, Protein dumpy-27.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC4 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=In interphase cells, diffusely distributed in nuclei before the onset of dosage compensation (PubMed:19119011). Associates with chromatin after the 30-cell stage when dosage compensation is initiated (PubMed:7954812, PubMed:23028348, PubMed:19119011). Specifically localizes to the X chromosomes of hermaphrodite (XX) embryos, but remains diffusely distributed throughout the nuclei of male (XO) embryos (PubMed:7954812, PubMed:23028348). dpy-26 is required for its X chromosome specific association (PubMed:8939870).