PharMolix/UniProtQA huggingface dataset:
Protein: RIBB_SHISS
Sequence: MNQTLLSSFGTPFERVENALAALREGRGVMVLDDEDRENEGDMIFPAETMTVEQMALTIRHGSGIVCLCITEDRRKQLDLPMMVENNTSAYGTGFTVTIEAAEGVTTGVSAADRITTVRAAIADGAKPSDLNRPGHVFPLRAQAGGVLTRGGHTEATIDLMTLAGFKPAGVLCELTNDDGTMARAPECIEFANKHNMALVTIEDLVAYRQAHERKAS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: TBB2_DAUCA
Sequence: MREILHIQGGQCGNQIGSKFWEVVCDEHGIDPTGQVLSESDLQLDRINVYYNEASGGRYVPRAVLMDLEPGTMDSVKTGPHGQIFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCECLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSGHQLVENADECMVLDNEALYDICFRTLKLSTPSFGDLNHLISGTMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRTLTVPELTQQMWDSKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQILNVQNKNSSYFVEWIPNNVKSSVCDIPPRGLSMSSTFIGNSTSIQEMFRRVSEQFTAMFRPKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEDDYDDGEGSTGD
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-2 chain, Beta-2-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ENO_JANSC
Sequence: MSVIIDIHAREILDSRGNPTVEVDVTLEDGTMGRAAVPSGASTGAYEAVEKRDGDKARYKGKGVLAAVEAVNGEIADTLVGFDATEQVAIDQTMCELDGTDNKGRLGANAILGVSLATAKAAADFTAQPLYRYVGGTMAHVLPVPMMNIINGGEHADNPIDIQEFMIMPVSATSIAEAVRMGSEVFHTLKSELSAAGLSTGIGDEGGFAPNLSSTRDALDFVLKSIEKAGYAPGDDMVLALDCAATEYYRDGKYELSGEGKSLTSDENVAYLAALVANYPIFSIEDGMGEDDWDGWIALTEALGDKVQLVGDDLFVTNPARLKDGIDRKAANSLLVKVNQIGTLTETLAAVNMATRAGFTSVMSHRSGETEDATIADLAVATNCGQIKTGSLARSDRLAKYNQLIRIEEQLEETANFAGRSILRG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RSMJ_GLAP5
Sequence: MNIQLINESDFTERFYDICEKWKLKHNPSSNLALVQTNERLELRKLNQPKLGAVAVNFVDGKMSYRRKFGGGRNEAIVKAVGVKGSYTPTIIDATAGLGQDAFVLASIGCYVKLIERNPIVGALLEDGLQRAYKDLEIGHFMRERMVLLPHSSITGLNPDLDSVDVVYLDPMYPSKTKSALVKKEMQLFQQLVGCDLDSDDLLFPAQQLARKRVVVKRPNYALFLANKKPDFCKETKKHRFDIYLSH
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF2_DINSH
Sequence: MATEATGAVEAAPGMPQLDFSTFPNQIFWLIITLVAIYLILTKVALPRIGSVLAERSGTITNDLAAAEELKLAAVEAEKAYNQALADARAEAQKIVAEARAEIQADLDVATAKADAEIAAKSAEAEKAIAEIREGAMASVTEVATDTAQALVAALLPSAKDADVSAAVAERVKG
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria (By similarity).
What are the official names of this protein?
ATP synthase subunit b 2, ATP synthase F(0) sector subunit b 2, ATPase subunit I 2, F-type ATPase subunit b 2, F-ATPase subunit b 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: COX6A_CAEEL
Sequence: MNRLAQPATRSVVKTFQRKSSGSFYGSNNVEGFKESYVTPLKQAHNASETWKKIFFIASIPCLALTMYAAFKDHKKHMSHERPEHVEYAFLNVRNKPFPWSDGNHSLFHNKAEQFVPGVGFEADREKH
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 6A, mitochondrial, Cytochrome c oxidase polypeptide VIa.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 6A family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: ZRAP_ECOL6
Sequence: MKRNTKIALVMMALSAMAMGSTSAFAHGGHGMWQQNAAPLTSEQQTAWQKIHNDFYAQSSALQQQLVTKRYEYNALLAANPPDSSKINAVAKEMENLRQSLDELRVKRDIAMAEAGIPRGTGMGYGGCGGGGHMGMGHW
What is the function of this protein?
Binds zinc.  Could be an important component of the zinc-balancing mechanism (By similarity).
What are the official names of this protein?
Zinc resistance-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ZraP family.
What are the subcellular locations of this protein?
Periplasm.
Protein: AROC_SYNE7
Sequence: MGSSFGHLFRISTFGESHGGGVGVVIDGCPPRLEISEAEIQFELDRRRPGQSKITTPRKEADQCEILSGVVDGKTLGTPIAIVVRNKDQRSQDYSEMQVAYRPSHADATYDAKYGIRAVAGGGRSSARETIGRVAAGAIAKKLLREIAGVEIVGYVKRIKDLEGQIDPETVTLEQVESTIVRCPDEAIAPQMIDLIEAIGREGDSLGGVVECVARRVPRGLGEPVFDKLEADLAKACMSLPATKGFEIGSGFAGTEMTGSEHNDAFYTDEQGQIRTRTNRSGGTQGGISNGENIVIRVAFKPTATIRKEQETVTNSGEATTLAARGRHDPCVLPRAVPMVEAMVALVLCDHLLRQQAQCSWW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: LPXD_PSYCK
Sequence: MITIEQLISQIEQRQPVLNKAELSAEQRRLSLEGIGNLTMANRQQLSFLANPHYLSSLANTDAGAVLITEEHHEEVPNDTVALIVAVPYLAYASVSQIFARQHSFSGIHPTAFIADSAVIGNKVTIGAFCVIGEQVQIGDRSVLEAHVVIEDNTTIGTDGVIKSQVVIGHDCIIGSHVRLHAGVTIGSEGFGFAPTANPSVTGWERIAQLGRVLIGDHVRIGSQTCIDRGAIDDTVIGNHVIIDNLVQVAHNVRIGDGTAIAAHTGIAGSTTIGKRCIIGGAVGITGHIDITDDVTLSGMTMVTKSITTAGSYSSGTAAMPTANWRRAAVRFRQLGRD
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: RLMN_STRP3
Sequence: MKPSIYSLTRDELIAWAVERGQKQFRATQIWDWLYKKRVQSFEEMTNISKDFVSILNDSFCVNPLKQRVVQESADGTVKYLFELPDGMLIETVLMRQHYGHSVCVTTQVGCNIGCTFCASGLIKKQRDLNSGEITAQIMLVQKYFDDRKQGERVSHVVVMGIGEPFDNYKNVMCFLRVINDDNGLAIGARHITVSTSGLAHKIRDFANEGVQVNLAVSLHAPNNDLRSSIMRVNRSFPLEKLFSAIEYYIEKTNRRVTFEYIMLNEVNDSIKQAQELADLTKTIRKLSYVNLIPYNPVSEHDQYSRSPKERVLAFYDVLKKNGVNCVVRQEHGTDIDAACGQLRSKTMKKDREKVTATK
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_PHEZH
Sequence: MPRTHKIEDYRNFGIMAHIDAGKTTTTERILFYTGKSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWNGKRLNIIDTPGHVDFTIEVERSLRVLDGAVTVLDGNAGVEPQTETVWRQADKYKVPRIVFVNKMDKLGADFDKSVESIRDRLGAKAVPIQLPIGAESALRGIIDLVRMKAVVWDTDALGAKFQDEEIPADLKEKAEAARNYMIENAVELDDEAMEAYLSGEEPSEEVIKKCIRKAVLTGAFYPILCGSAFKNKGVQPLLDAVVDYLPSPVDIPPTKGIDFRTEEEVERRASDDEPLSVLAFKIMDDPFVGSLTFCRIYSGKLETGMGLMNSTRDKRERVGRMLLMHSNNREDIKEAYAGDIVALAGLKETRTGDTLCDPNKSPVILERMEFPEPVIEIAVEPKSKADQEKLGVALSKLAAEDPSFTVSTDHESGQTILKGMGELHLDIKIDILKRTYKVEANIGAPQVAYRESISKRTEIDYTHKKQTGGTGQFARVKLVFEPGEPGSGFVFESAIVGGAVPKEYVPGVQKGLESAKENGLLAGFPVIDFKATLVDGAFHDVDSSVLAFEIASRAAFKELREKGGPKLLEPIMAVEVVTPEEYLGSVIGDLNGRRGQIQGQDMRGNATVINAFVPLANMFGYVNNLRGMSQGRAQFTMLFSHYETVPQVVAEEVIKKYA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYAP_ORYSJ
Sequence: MEAAALLSPTATSRSPLPLLSTAPAAHRLHVLLPLSGRRRRLCLRSSPRPRGSLGCAGDCVVRSMGSSRERGVLVKTSSSSASVESATQEVGAASSGEWSGDAIRRRFLDFYAARGHKILPSSSLVPDDPTVFLTIAGMLQFKPIFLGKEPRRVPCATTSQKCIRTNDIENVGRTSRHQTFFEMLGNFSFGDYFKKEAITWAWELTTKEFGLPPERLWISVFQDDDEAFSIWHNEVGVPKERIKRLGEDDNFWTSGATGPCGPCSEIYYDFYPERGSSDADLGDDSRFIEFYNLVFMQYNKKDDGSLEPLKQKNIDTGMGLERMARILQKVPNNYETDLIFPIIEKAASMALVSYTTADDAMKTNLKIIGDHMRAVVYLISDGVIPSNIGRGYVVRRLIRRVVRTGRLIGIRGDGHGNSEGAFLPSLAEVAISLSTEIDPDVESRRKSILGELQREELRFVQTLERGEKLLDELLDEALSSAGNNGGKPCLSGKDVFLLYDTYGFPVEITAEISGERGVIVDMKGFDMEMENQRKQSQAAHNVVKLSVGNETEIVKSIPDTEFLGYDSLSATAVVKGLLVNGNSVNVVSEGSDVEIFLDRTPFYAESGGQVGDNGFLYVYGEEDAKQKAVIEINDVQKSLGNIFVHKGTIKQGSVEVGKEIDAAVDAKLRQGAKAHHTATHLLQSALKSIIGSETSQAGSLVAFDRLRFDFNFHRPLSEEELMKIESLVNQWVSSATHLETKVMDLQDAKNAGAIAMFGEKYGEQVRVVEVPGVSMELCGGTHVSNTAEIRGFKIISEQGIASGVRRIEAVAGDAFVEYVCARDNYMRCLCSSLKVKAEDVNGRVETILEELRTTRNEVSSLRSKIAVLKAASLANKATTIDNTRVVVENMGDVDADGLKSAAEYLVDTLEDPAAVILGSSPGDGKVSLVAAFSPGVVKMGIQAGKFVGGIAKLCGGGGGGKPNFAQAGGRKPENLPGALEKARDEIVAAISSKSS
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, chloroplastic/mitochondrial, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion.
Protein: CAID_SALDC
Sequence: MSESLHLTRNGPILEITLDRPKANAIDAKTSFAMGEAFLNFRDDPELRVAIITGGGEKFFSAGWDLKAAAEGEAPDADFGPGGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCAENASFALPEAKLGIVPDSGGVLRLPKLLPPAIVNEMVMTGRRMSAEEALRWGVVNRVVSQSELMDSARELAQQLVNSAPLAIAALKEIYRATSEMPVEEGYRYIRSGVLKHYPSVLHSEDALEGPQAFAEKRDPVWKGR
What is the function of this protein?
Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.
What are the official names of this protein?
Carnitinyl-CoA dehydratase, Crotonobetainyl-CoA hydratase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: OPS2_BEAB2
Sequence: MRFLAGGASASVAAVGAGTVADLWEVKRRGTAMGYFFLGPMLGPLVSPIIGGILTQRFGWRSTQWGAVVYGGLVWLSMIFLLPETSSKAVKGKEPAVAENSDDGNVQPVPESCVSRFFKALGRMLVEPFRLVGYLRSPPLFMTCYYASISFACYYILNLAIQRTFSRDPYSFRAIILGLLYIPSALGSIVASVVGGRWTDYVMRREAKAAGRFDESGNPKFRPSDRMCENAWIPAFVFPAALLVFGWTTHEGIFWFAPIVVTFFFGLGNSLIFNTATTMLTEILPGKASNAVALNNLMRNTLSCAAAVATDPLLGAIGTQWLFTGLAVICWASSGVIWALKRHSDKAPSA
What is the function of this protein?
MFS transporter; part of the gene cluster that mediates the biosynthesis of the bibenzoquinone oosporein, a metabolite required for fungal virulence that acts by evading host immunity to facilitate fungal multiplication in insects (PubMed:26305932).  The function of this putative MFS transporter remains unclear since its deletion leads to increased oosporein production (PubMed:26305932).
What are the official names of this protein?
MFS transporter OpS2, Oosporein biosynthesis protein 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COPRS_HUMAN
Sequence: MDLQAAGAQAQGAAEPSRGPPLPSARGAPPSPEAGFATADHSSQERETEKAMDRLARGTQSIPNDSPARGEGTHSEEEGFAMDEEDSDGELNTWELSEGTNCPPKEQPGDLFNEDWDSELKADQGNPYDADDIQESISQELKPWVCCAPQGDMIYDPSWHHPPPLIPYYSKMVFETGQFDDAED
What is the function of this protein?
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5.  Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5.  Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5.  Involved in CCNE1 promoter repression.  Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).
What are the official names of this protein?
Coordinator of PRMT5 and differentiation stimulator, Cooperator of PRMT5, Protein TTP1.
Protein: NADK_LARHH
Sequence: MNWLFKKIGLVARQSKPEVVESLLLLSHHLESQGLHVFIDRDSVTRSQAQGLTLIDRSDFGKIVDVAIVLGGDGTMLSVARLLAPYRVPLIGINQGRLGFMTDIPLHQMLDSVSAILSGEFLPEERMLLQSTVVRDGVEIAHHLAFNDIVINRGAMGQMIEFEVFVDNQFVYSQRSDGLIISTPTGSTAYSLASGGPILHPTVPAISLVPICPQSLNNRPIAINDSSEVEFMLTRGIDARVHFDGQAHCDLMELDRVLVRRYRNSLKILHPLGYSYFDMLRQKLHWGERLL
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCL3_ARTOC
Sequence: MRWLFWTSENDKDECKCNNKPSSNSDEKPSIILNSSKDWNALSNATNWSHFLEPSNLIPTVLLTSGILFAVRIHRRYLRRIPEATNISPSYLRQRSILGKVTSVGDGDNFRIYHTPGGMLAGWGWLRKVPTSKKELKNNTIHIRIAGVDAPELAHFGRPSQPFGEEAHTWLTNRLIGRRIRAYVYRPDQYSRVVATVYAYRFLFFPQDIGLQMLREGLATIYEAKSGAEFGGPKQEKKYRDAEALAKKKGKGLWKAKASSDWESPRDFKSRMNAIDQGKGST
What are the official names of this protein?
Probable endonuclease LCL3.
What is the protein family that this protein belongs to?
Belongs to the LCL3 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single- pass membrane protein.
Protein: ILF3B_XENLA
Sequence: MRPMRIFLNDDRHVMAKHSVVYPTQEELEAVQNMVSHTERALKAVSDWIDQQEKDSGIEQENPEPEETETTEEGKDSEAKTGENPTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCRDKPTISLLKRVADNLVLQFETVSEDKYEVVQNIREASIVIKNTKEPPLTLHIRLTSPLVREEVEKLSAGETLTVSDPPDVLDRHKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWEPLRGWPLELLCEKAIGTANRPMGAGEALRRVLECLSSGILMPDGPGLYDPCEKDASDALEHLERQQREDITQSAQHALRLAAFGQLHKVLGMDPLPTKMPKKTKIEIPIIDYTVQIPPSTTYAMPALKRPIEEDGEDKSPSKKKKKIQKKDEKSEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDDKTFEASGPSKKTAKLHVAVKVLQDMGLPTGIDEKEESVDESEEKPVLQTPSQTADSEQADSSAGDQSESGKQQGPILTRHGKNPVMELNEKRRGLKYELISETGGSHDKRFIMEVEVDGVKFQGNGSNKKVAKAYAALSALEKLFPDYTTYTEAPKKKRPPMMPRGGPKFAGKHNQGFGMMYNEVPPPQVMRGRGRGGMNRGRGRGRGGFGGGNYGGYMNSGGYGGGYGGNNYQTSATAGYSQFYSNGGASGNAGGGGAGSGGYSSYYQGEGYNAPTPPKPFVKKPPPPQQQQQPPPQHASNPPKPSYNQGYQGHQGGQQQQQPQQQQQQTYNQNQYSNYGPPQKQKGGYNQGTQGAASAGSYNYSNSYTGGTACRVRQWRGCRRARRPALTQRQALVTTQGRTPAMVQPAVPHRTKVTHSRTTIKVPPDRTTAALQIITSPLREEQEVMAGIQITT
What is the function of this protein?
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs.  Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons.  Plays thereby a role in the back-splicing of a subset of circRNAs.  As a consequence, participates in a wide range of transcriptional and post-transcriptional processes.  Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity).  Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response.  Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs.  In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.  Has a cytoplasmic role early in development as part of a ribonucleoprotein (mRNP) complex which may regulate mRNA transport and/or translation.  Following nuclear localization at the mid-blastula transition, acts as a transcription factor and binds the 5'-CCAAT-3' promoter sequence to regulate transcription of the gata2 gene as a subunit of the CCAAT box transcription factor (CBTF).  Its role as an mRNP component negatively regulates its activity as a transcription factor by precluding its nuclear localization.
What are the official names of this protein?
Interleukin enhancer-binding factor 3-B, Double-stranded RNA-binding protein 4F.2, DsRNA-binding protein 4F.2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Cytoplasmic in fertilized eggs, then translocates to the nucleus prior to gastrulation. RNA-binding is required for cytoplasmic retention during early development, and nuclear translocation at the mid-blastula transition (MBT) is probably coupled to the degradation of maternal mRNA that occurs at that stage (By similarity).
Protein: RL1_MAGSA
Sequence: MAREGKRLKSAYADIDRDKFYSLADAVKAIKTRAVAKFDETIEIALNLGVDPRHADQMVRGVVELPHGTGKTVRVAVFAKGDKAEEARKAGADIVGEQDLFDACNAGNMDFDRVIATPDLMGLVGRLGKVLGPRGLMPNPKLGTVTANVTEAVRAAKAGQVQFRVEKAGIVHAGIGKASFSEEKLAENVKAFVDAITKAKPQGAKGTYLKKVSLSSTMGPGVKLDVATLA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: SEQA_VIBCH
Sequence: MKTIEVDEDLYRYIASQTLHIGESASDILRRLLNVDGELATAAPAAEPKGIVVSKDAAFDTKIDGVKAMRSLLISDEFAGLKNAIDRFMLILSTLHRIDSASFSEATMFKGRKRVYFADNEQTLLASGQTTKPKAIPNTPFWVITNNNTSRKQQMVEQVMVRMGFPSDIIEKVTHSI
What is the function of this protein?
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle.  Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins.  Repression is relieved when the region becomes fully methylated.
What are the official names of this protein?
Negative modulator of initiation of replication.
What is the protein family that this protein belongs to?
Belongs to the SeqA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_LIGS1
Sequence: MTPEEFRQSLAGQGLNLTDEQMQQFELYYEFLVETNKNLNLTAITEKNEVYLKHFYDSLLLALTVKDLQTEELSLCDVGAGAGFPSLPVKIAFPQLKITIVDSLNKRIKFLQELTQKLNLQDVHFHHARAEEFGGKRSVHRERYDLVTARAVARMSVLSELCLPLAKVGGRFIALKAQKSDEELKNAQKAIEVLGGKVIADYATELPQVHDERHIIVVAKEKETPKKYPRKAGTPAKSPIE
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT5A_CONAL
Sequence: FCCPFIRYCCW
What is the function of this protein?
Causes dorsal fins drooping in fish.  No effect is observed when injected into mice.
What are the official names of this protein?
Conotoxin au5a.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LEA13_GOSHI
Sequence: MQSMKDAAASAKAGMEKAKASMQEKVDQMKTRDPNEKEMARERKEERQEDAELRKQEARHHNATAGHVGGGGIGGTGYTTAGYNIGDTGGYGGTGGHDNRGYPTAGSGYDTGRQDDLSSMGFGGDTEGAYGTTGNQDFPNAASNNAGTRRNTRGGTQDDPYYRSY
What is the function of this protein?
LEA proteins are late embryonic proteins abundant in higher plant seed embryos.  There are two subsets of LEA proteins (5a and 5b), the first ones are expressed when the cotyledon weight reach 80 mg and the second set are expressed above 100 mg.  The function of those proteins is not known.
What are the official names of this protein?
Late embryogenesis abundant protein D-113, LEA D-113.
What is the protein family that this protein belongs to?
Belongs to the LEA type 1 family.
Protein: FMT_FRAAA
Sequence: MRLVFAGTPAVALPSLRALIDSPRHEVVAVVTRPDRPAGRGRKIKPPPVHLLADEAGIPVLSPERPRDPDFLAALTDLAPDCCPVVAYGALLPREALAIPRHGWVNLHFSLLPAYRGAAPVQRTVLAGDDLTGASVFQIEPAMDSGPVFGVVTERVRPTDTSGDLLDRLADSGAHLLAAVMDGIDDGTLQAVPQPAEGVSFAPKLTAQDALIDWTLPAVAVDRLTRAAAPAPGAWTVFRDRRIKIGPVRLGAQNVPDELAPGRLVALADGAVAVGTGTAPVLLDEVRPEGRGPMKAADWARGARLTDDDLLHAPAERVSAAGSPAGAGGAP
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.