PharMolix/UniProtQA huggingface dataset:
Protein: CP27B_HUMAN
Sequence: MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR
What is the function of this protein?
A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis.  Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:10518789, PubMed:9486994, PubMed:22862690, PubMed:10566658, PubMed:12050193).  Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway (PubMed:10518789, PubMed:22862690).  Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR.  Also active on 25-hydroxyvitamin D2 (PubMed:10518789).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:22862690).
What are the official names of this protein?
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, 25-OHD-1 alpha-hydroxylase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, VD3 1A hydroxylase, Calcidiol 1-monooxygenase, Cytochrome P450 subfamily XXVIIB polypeptide 1, Cytochrome P450C1 alpha, Cytochrome P450VD1-alpha, Cytochrome p450 27B1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion membrane.
Protein: QUEC_THEAC
Sequence: MERKKAVVLLSGGLDSSTVLAYAISLGYEVHAISFDYGQRHSREMNSSEELAKYYGVDRKIVHVDLRSIGKSALTDDIEVPSRDLESIPEEIPVTYVPARNTIFLSIAAAYAESIGSTDIFIGANAIDYSGYPDCRPEYFNAMEKALTLGTEIGLRKGMHINVPLQYLTKADIIRMGLKLGVPYEKTWSCYKGGEKACGECDSCLLRLKGFMEAGSEDPLEYEKYPTFYKDYIEKRKK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, Archaeosine biosynthesis protein QueC, PreQ(0) synthase.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RL361_ECOLC
Sequence: MKVRASVKKLCRNCKIVKRDGVIRVICSAEPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: Y2422_STAA3
Sequence: MTVLTDKVAVVTGAGSGIGEAIATLLHEEGAKVVLAGRNKEKLQNVANQLSQDSVKVVPTDVTNKEEVDELIKIAQQTFGGLDIVINSAGQMLSSKITDYQVDEWDSMIDVNIKGTLYTAQAALPTMLEQSSGHLINIASISGFEVTKSSTIYSATKAAVHTITQGLEKELAKTGVKVTSISPGMVDTAITAAYNPTDRKKLEPQDIAEAVLYALTQPKHVNVNEITVRPV
What are the official names of this protein?
Uncharacterized oxidoreductase SAUSA300_2422.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RUVA_STREM
Sequence: MYDYIKGQLTKITAKYIVVEANGLGYMITVANPYSFTDCVNQQVTIYLHQVIREDAQLLFGFHSEEEKDVFLKLISVSGIGPTTALAIVAVDDNRGLVNAIDNSDITYLMRFPKIGKKTAQQMVLDLAGKFVEAPKEESSKLPKAKHQENEQLDEAIEALLALGYKATELKKIRAFFEGTSETAEQYIKSALKMLMKG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: HIS1_SHEDO
Sequence: MPNTQRLRIAIQKSGRLSKESQQLLKSCGVKFTVNEQRLIAHADNMPIDLLRVRDDDIPGLVMDGVVDLGIIGENVLEEEQIERQTLNKPSTFIKLRELDFGSCRLSLAVPNEFDYQDVSSLSGLRIATSYPNLLRRFMAEKGISYSDCMLKGSVEVAPRAGLSDAICDLVSTGATLEANGLYETEVIYRSTACIIQSNEAQTAEKQVLINKILSRANGVIRARESKYILLHAPTETLEQIIALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTALGASSILVMPIEKMMG
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_ECOL5
Sequence: MFRGATLVNLDSKGRLSVPTRYREQLLENAAGQMVCTIDIHHPCLLLYPLPEWEIIEQKLSRLSSMNPVERRVQRLLLGHASECQMDGAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWHQQVKEDIDAEQLATGDLSERLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DEF2_NIGSA
Sequence: KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKLPAHRCICYYEC
What is the function of this protein?
Antimicrobial peptide active against fungi, Gram-positive and Gram-negative bacteria.  Inhibits growth of hyphae in the fungi A. niger (IC(50)=3. 5 ug/ml), B. sorokiniana (IC(50)=1. 8 ug/ml), F. oxysporum (IC(50)=5. 3 ug/ml), F. graminearum (IC(50)=6. 9 ug/ml), F. culmorum (IC(50)=6. 9 ug/ml) and B. cinerea (IC(50)=13. 7 ug/ml).  Has no effect on spore germination.  Destroys spores in germinated conidia by disruption of cell walls and membranes in A. niger and B. sorokiniana.  Causes vacuolization of germinated macro- and microconidia in F. oxysporum, F. graminearum and F. culmorum.  Strongly inhibits growth of P. infestans on potato tubers above concentrations of 3. 4 ug/ml.  Inhibits growth of Gram-positive bacteria C. michiganensis and B. subtilis and of Gram-negative bacteria P. syringae, E. carotovora and E. coli.
What are the official names of this protein?
Defensin D2, Ns-D2.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: RIBA_HAEIE
Sequence: MAKIQLVAQANLPTEYGIFKMVGFEFLDTKKEHVALVMGDISNADEPVLARIHSECLTGDALHSLKCDCGFQLATALKQIQEEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLALGFKADERNFEVCADMFELLGVKKVRLMTNNPEKVETMKKAGINVVERVPLNVGENRYNTKYLDTKAKKMGHYIVHNNDEQHLMTCPHCQEEII
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: DPCHG_COLHI
Sequence: MTSSEKNSTGLAGKTCLVTGGAGGLGKAVTAAFLDAGANVVICDINAKRIESTLAELRTRGGNLTAVTADITDHDQVLSLFDDIAGRFGTLDVLVNNAAVMDRFDPVGDIELDLWDNVLAVNLTAPLQLSKFAVRSMLSKPEPAGCIINIASGAATAGWLAGTAYTASKHGLVGLTKSTAAFYGPKGIRCNALIMGVMVGTHMHEAFLDGCHKEGRQKVEEIFSGHRPQTCKVDDVAGICLSLASGPGWGTVNGALIAVDNGWTSVVG
What is the function of this protein?
Short chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of the diterpenoid pyrones higginsianins A and B (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpchA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpchD through the action of the prenyltransferase dpchC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpchE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpchB (Probable).  The short chain dehydrogenase/reductase dpchG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpchH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Finally, the FAD-dependent oxidoreductase dpchF converts higginsianin B into higginsianin A (PubMed:32286350).
What are the official names of this protein?
Short chain dehydrogenase/reductase dpchG, Diterpenoid pyrone biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PIPE_DROME
Sequence: MSLNAERSYKMKLRDVENAFKYRRIPYPKRSVELIALLAISCTFFLFMHTNKLNSRLKEMEVKLQPSEFSALGLTGNHISGHDAGKHDDINTLHGTYQYLKSTGQKVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDKQLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDFVFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPKPHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAIPMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEAAMQKAKRTVETEYAVVGTWEDTNITLSVLEAYIPRYFRNAKVAYYLGKDRLSRVNRNNVTRIVSDETRLILRKNLTNEIEFYEFCKQRLYLQYAALSHGKRFGEDDYLLVPEQQNEYNEDY
What is the function of this protein?
Sulfotransferase involved in dorsoventral axis patterning in early embryos.  Required for the specific ventral activation of a series of proteases acting in the perivitelline space between the embryonic membrane and the eggshell.  Probably acts by mediating the sulfation of some glycoprotein or glycosaminoglycan stably deposited in the egg, whose ventrally localized modification leads to spatially restricted activation of the protease cascade.
What are the official names of this protein?
Heparan sulfate 2-O-sulfotransferase pipe.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 3 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Note=Wbl is required for its processing into the Golgi.
Protein: EFTS_CROS8
Sequence: MAEITASLVKELRERTGAGMMECKKALVEANGDIELAIENMRKSGAIKAAKKAGNVAADGVIKTKIEGNYGVILEVNCQTDFVAKDGGFQAFADKVLDAAFAGKITDVEALKAQFEEERVALVAKIGENINIRRIASLEGDVLASYLHGARIGVLVAAKNADEELVKQLAMHVAASKPEFVKPEDVSADVVEKEYQVQLDIAMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMDPSKTVAQLLKEHNADVTNFIRFEVGEGIQKVETDFAAEVAAMSRQS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDH_SHEPA
Sequence: MKALSKLKPEEGIWMVDAPKPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQNTIPVPMVVGHEYVGEVVGMGQEVRGFTIGDRVSGEGHITCGHCRNCRGGRTHLCRNTSGVGVNREGAFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELAEKMGATRAVNVAKENLEDVMQELGMTEGFDVGLEMSGVPSAFHSMLDTMNHGGKIAMLGIPGGDMAIDWSKVIFKGLIIKGIYGREMFETWYKMASLIQSGLDISPIITHHYSIDEFQQGFDAMRSGQSGKVILNWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYQ_BUCA5
Sequence: MDTKKEIKNNNFICQIINKDLNENKNLSFYTRFPPEPNGYLHIGHAKSICLNFELASLYKGRCNLRFDDTNPLKENIKYIKSIKYDINWLGYKWHGNVRYASEYFLKLYQYAQELIKKGLAYVDHLTKEQIREYRGTLNTPGKNSPYRNRTIQENIELFEKMKKGDFSEGEACLRAKINMSSSSIIMRDPVLYRIIFIKHHQTQNKWCIYPMYDFAHCLSDSIEGITHSLCTLEFQDNKFLYNWILKNTSVKHYPKQYEFSRLNLEFSILSKRKIKILIDKNIIEGWDDPRIPTLSALRRKGYTPSSIKNFCQKIGVTKQNNLIEFSMLEHCIRKELNQTAIRTMAILDPIKIFLYNLDSNYKEEFIVPNHPNNPEMGTHKIIFTNTIYIDRSDFKEKYDKKYKRLKLGEKIRLRYSYIIHAEKIEKDEYGNISNIICYCDLNTLGRKPKDNKNPAVIHWISEKNTLSAEFKLYDQLFNIKNPEQQENFLLYINSKSLIKKFGFIEKKIGEEIQKKISNNNIEIFFQFERIGYFCIDFIDSKKNQLVFNRTVGLRDTWDSKKIKTKNITNN
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CINAL_SHEPA
Sequence: MKLEMICTGEEVLAGQIVDTNAAWFGNTMMEHGIECQRRVTVGDRLEDLVSVFKERSHEADVILVNGGLGPTSDDLSAEAMSLAKGEALVENEIWRERLENWFTRNGRVMALSNLKQAMLPESAIMIDNPVGTACGFAVKLNRAWLFFTPGVPFEFKQMVYEQFIPFVKQRFDIAGDVALRKLLTLGQGESSLADTLEQIDLPSGITIGYRSFMPHIEIKLFARGVGAIAQLDRLEAQIRFLLGNAIVACDRKSLAEEIHSLMVNSGLSLSTAESCTGGMIASQLIDLSGSSSYLDQGLVTYSNESKVRVLGVKPETLDDHGAVSIATVEEMAKGVRSILNSDFALATSGIAGPTGGTDDKPVGTVAIALATKGGVYSQMIKLPRRSRELVRSLSTAVAFDMLRRELLGEAVIVDYGSIGRFQK
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: RL20_RHOPT
Sequence: MARVKRGVTAHAKHKKVYKLAKGYRGRRKNTIRTAKAAVDKAGQYAFRDRKRKKRTFRALWIQRLNAAVRPFGMTYSVFINGLSKSGIVVDRKVLSDLAINEPAAFQAIAEKAKAALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PDXJ_NITOC
Sequence: MIASHAILLGVNIDHVATLRQARGTRYPDPIQAAIEAEQAGADGITLHLREDRRHIQERDVALLRDVLVSKMNLEMAVTGEMLAIAEKYCPEDCCLVPERREELTTEGGLNVTGQLARITEACVRLKEAGTRVSLFIDADPRQVEAAAQANAPVIEIHTGHFADARDERNRRKEFQRIVEAVKRGREVGLQVNAGHGLNYQNVAAIAALSDIVELNIGHAIIARALFTGMQSAVGEMKRLMREARE
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_MYCA9
Sequence: MRIVFAGTPAPALPSLERLLASRHEVVAVLTRPDARAGRGRASASSPVAALAREHGVAVLTPARPNEPEFVRELAQLDVDCCAVVAYGALLKPELLAVPRLGWVNLHFSLLPAWRGAAPVQASIAAGDEITGATTFLIEPALDSGPVYGVVTERISPNDTAGALLGRLAESGAGLLESTMDGIEDGALVAVPQAVDGVSIAPKITVEQARIRWELPAHAIDRHIRAMTPEPGAWTNIGGTRVKVGPVGVATDEQLPPGAVAVRKRDVLVGTGTTAIALDEVQPQGKKVMKAADWARGARLDAEVHAL
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: CTC1_DANRE
Sequence: MEEFLNNFKSYSRADQRWLSAVFEAVQQQFSPLLDSDGFSVARLAQSVVEKVQRAVGSDCADLPVSYRIVSVSELIRDQRTACCSSLCWSSAHYRDQAKKAEQTLPNYKALPRDNLLLIGFLCDGRADGKSEGEWRVRDAGGSVPCMMLKSSCLWLGRLMLFPTWNYIPQNAPGAAGYLELVDPPVCVTLEAMTFDPGGALTEVMSVRHAAELLAHSCEDQVCVCVGGQVCVVGPLLLIRGKRFFCLVLSDGGSSVALIIRELKHQYWRQCVCVGQSVWISSLRVCSLGALEGRRVLTDSCQSRLHPHTPLQESSEEQDTEDDTHTPADTTHTLADATRTPADDTRLASDPAVRVKPSTIISFKGTVTKILNAEAGLYELDGQVGLCLAYQPTQKWGGGLRPGAEIQLHNVHFTYQASAFAPRAVLWACLRSSVQITAFSRLCSELQVTEPHGALQRLLLERNLGPSQYLWLCYCQKAIAERLSPRWVRPDRVCVVAGRLLDAVCDAEQKTKKKRNIYTEMIQEPHHCPISMYCVRWPSAALWSVQQLCVWMQREVWSSLSLPALLSASAPHMTALELNSALRWSSVELRLEEASPDPLLLLGVLELQAESATLQLRDHTHKLHCLCVCRDHSPNISTAWQGCLVCVRRCTLVMERFMKTNFPSWKHLDQPSYITLKHCRVYLQLCMDDLIIISPSSSMSHQMAESKLTHGHTHRSCGESSKRLRSADAGVCERADSSAVCVSLLFRLENKHGVTLQNVSADTHTRQLGFKCRAVCVGGVQRWSHDPKNCRIQERERDGGGQTVELHFRGSCVRWFPVLHPGCVYRLIALNTEDVGVLEAKGVSARGGVTQLSSPSLLLQPQWRVHTLPEEPADAQAAAPALMSVSEVLHSSSAPEVVSFHGIISQRITLQEDNEAQPKIKSVSPTADTQEDLRVRLTVQDAECPGLMVHVYLDLSCGLYTLGLITGAALQVHHVQRKVSRACNVYCRSLPISYVSVTGLRSVCSGPAAAAPPPPMMLLGSWASVGSQQCLVAQVKGHVVCVLSLRLQWICSLCGSIFTQTTCGRTHPPCDSTSAVFQAEAKVVLEDGTGEAHVWFSSESVCGLLMLNAVQWEGLQRLVRVKGHVKVYTRGRTMTCDDSPDDSIVQYLSCLCSSVSVCRQIHVTCRRRAQKTGKSQLRKVHRGQTEFICKFPPALQLQCQHIHTR
What is the function of this protein?
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex.  The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves.  Initially the CST complex has been proposed to protect telomeres from DNA degradation.  However, the CST complex has been shown to be involved in several aspects of telomere replication (By similarity).
What are the official names of this protein?
CST complex subunit CTC1, Conserved telomere maintenance component 1.
What is the protein family that this protein belongs to?
Belongs to the CTC1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: HIS6_CLOB8
Sequence: MHTKRIIPCLDVKEGRVVKGINFEGLVDVGDPVALAEYYNKQGADELVFLDITATHEKRGIMEKVVQSVAEKIFIPFTVGGGLQTLDDIKSILRAGADKVSLNSAAVRNKMLIKEGAFYFGSQCIVLAADAKKRSDNTGWNVVINGGRIDTGLDLLKWIEEATALGAGEILLTSMDADGTKKGFDLELTKAVSDITNVPVIASGGCGCLEDFYDVFKSNIADAALAASLFHYGELTVDEVKRYLHDKNVSVRI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_ANASK
Sequence: MAIQHRDPRGGGGSRDARTNRRIKAREVRVIGAEGEQLGVLPIDQALARAQELGMDLVEVSPMAKPPVCKIMDYGRFKYLEKKKQNEAKKKQVVVQLKEVKLRPRTEEHDYDTKIKKVRAFLGEANKARITVMFRGREMSHRELGQKVLQRVIEDLRDVAVIESAPRMEGRQMFMILAPNPKMLQSQRDKAKAAAAAAPAAAPAAGAPAPTPAPAPAAPAPAPAAADPAAQR
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_STRPM
Sequence: MKLMTMPSEFQKALPILTKIKEAGYEAYFVGGSVRDVLLERPIHDVDIATSSYPEETKAIFNRTVDVGIEHGTVLVLENGGEYEITTFRTEDVYVDYRRPSQVSFVRSLEEDLKRRDFTVNALALDENGQVIDKFRGLIDLEQKRLRAVGKAEERFEEDALRIMRGFRFAASLDFDIEAATFEAMRSHSPLLEKISVERSFTEFDKLLMAPHWRKGISAMIACQAYDYLPGLKQQEAGLNHLIVSLKDNFTFSDHHQAWAYVMISLAIEDPKSFLKAWKTSNDFQRYVTKLIALYRIRQERSFEKLDIYQYGKEMASLVEGLRKAQSLSVDMDHIEALDQALAIHNKYDIVLNGSHLIKDFGMKPGPQLGLMLEKVELAIVEGRLDNDFTTIEAFVREELAT
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: ZGPAT_DROYA
Sequence: MEEYEAQLLVVEQALENAADEAQRQDLLALKNNLQELLALTRDTGDEAHTDELPQQGDDLDDELQRLKSELSDLEAVGSSQTALDEERQLADLRTKYTAMVGEKCSAPHEHSWGTCYHNALICGVDDEVVMNSEGVLDARLRVLFTNPTHREMLPCSYYLEGECRFDETKCRFSHGALVPGSSIRKYNPPDFHKLSRSRPVFALLPDRLWHRGRVLCVNFVEQVCRVRLDGQDHKERERDFKFEELFPLTTDQDEDDELSSEESNSSMNDDSSDEAESDMDDLEEARRARMVELSLFTFKPTERLGAWEEFTRGIGSKLMEKMGYIHGTGLGSDGRGIVTPVSAQILPQGRSLDACMELREAANGDKDYFSVERKLKRAQRRQRKADEKAYVRESQRVDVFTFLNDSVLGPGESSQQGEQVAKKIKTNELQQHSTKTLNVETVRIADEIRRKQRDMAKVKQSLDRNSGDAQLQKRLQVQMESHKQELATLQAQERSLSKEQQTRKSKNKMFEF
What is the function of this protein?
Transcription repressor.
What are the official names of this protein?
Zinc finger CCCH-type with G patch domain-containing protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: MU172_SCHPO
Sequence: MTTPIVFCNPSNIEESLLYINKSLFSKGVIQAEKLRLSHDIRDNCNIVNIIYRLLRATDEERLEKESLLDAIKNNEYEKQRDNNTIKRLKNELELYQNECQLQLNKVRTLERDQAELITQNKGLKDVNAKNELTLKALKNQLSVSLRQHEQQMETLKGNYGLVKARKGRNLNSMLIVKEPIKQNTNAPILPETASFLQQNDENSNFLNSRVNNDEFQLLKGLNNELKKSNGTLLTCLSGTLNSLVEMLSPLYERPNSNPFEVCELNAILLDAKIQNQLLFIRNLLHERKYVSIDELDAILEENEKNKHLINILQKENKRVFEFLTNMHDKF
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 172 protein.
What is the protein family that this protein belongs to?
Belongs to the ADIP family.
What are the subcellular locations of this protein?
Cytoplasm.