PharMolix/UniProtQA huggingface dataset:
Protein: C209E_MOUSE
Sequence: MRAPQMGSLGFLDKGHIPLVLQLLFLILFTGLLVAIIIQVSKMPSSEEIQWEHTKQEKMYKDLSQLKSEVDRLCRLCPWDWTFFNGNCYFFSKSQRDWHDSMTACKEMGAQLVIIKSHEEQSFLQQTSKKNSYTWMGLSDLNKEGEWYWLDGSPLSDSFEKYWKKGQPNNVGGQDCVEFRDNGWNDAKCEQRKFWICKKIATTCLSKW
What is the function of this protein?
Putative pathogen-recognition receptor.  May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments.
What are the official names of this protein?
CD209 antigen-like protein E, DC-SIGN-related protein 4, DC-SIGNR4.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: SACA3_MOUSE
Sequence: MGICMSMYTQVLVPVDADGDHHILWSRFYERWGSCFNPCAGLVNCLPPHSSALYLCHRMEARSRAPRRQLCPPGITWLALAYLLSCLLASSKAKVFSRCELAKEMHDFGLDGYRGYNLADWVCLAYYTSGFNTNAVDHEADGSTNNGIFQISSRRWCRTLASNGPNLCRIYCTDLLNNDLKDSIVCAMKIVQEPLGLGYWEAWRHHCQGRDLSDWVDGCDF
What is the function of this protein?
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.  It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane.  The processed form has no detectable bacteriolytic activity in vitro (By similarity).
What are the official names of this protein?
Sperm acrosome membrane-associated protein 3, Lysozyme-like protein 3, Sperm lysozyme-like protein 1, mSLLP1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type II membrane protein. Note=Anterior acrosome in non- capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: UCRQ2_ARATH
Sequence: MGKQPVKLKAVVYALSPFQQKIMTGLWKDLPEKIHHKVSENWISTILLVAPVVGTYSYAQYFKEQEKLEHRF
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
What are the official names of this protein?
Cytochrome b-c1 complex subunit 8-2, mitochondrial, Complex III subunit 8-2, Complex III subunit VIII, Ubiquinol-cytochrome c oxidoreductase subunit 8-2, Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C.
What is the protein family that this protein belongs to?
Belongs to the UQCRQ/QCR8 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PUR9_ENTFA
Sequence: MTKRALISVSDKTGVTTFAAGLVANGFEIISTGGTRTVLEEAGVPTLAIDDITGFPEMLDGRVKTLHPNIHGGLLAKRGNQAHQKALTEQGIHFIDLVVVNLYPFKETILKPAISEAEAIEMIDIGGPSMLRSAAKNYQDVTAVVDPSDYEQVLSEISSTGTSQLATRKRLAAKVFRHTAAYDALIADYLTTQVGETEPEKQTLTYERKQTLRYGENSHQQATFYQSVVPVSLSIASARQLHGKELSYNNIRDADAALRIASEFTEPTVVAVKHMNPCGIGTGKTILAAYRQAFEADPVSIFGGIVVLNRPVDQATAAEMHQIFLEIIIAPSFEEEALALLSQKKNLRLLTLDFHAQEKKAVELVSVMGGLLIQEQDTVVENDQAWQVVTERQPTPAERDALNFAWKAVKHVKSNAIVLANESQTVGIGAGQMNRIGSVKIAVDQAQAAGKLQGAVLASDAFFPMADSVEYAAQHGIQAIIQPGGSIKDQASIDLANHYGIAMIFTGTRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: LYB_BACIU
Sequence: ISPLGSVTKKNQDSTAYNWTGNKTANGNWPVLGICAVHRKKDIGGSGNSPVIPFGTTLKTDKDIWLPDGVGYKSSFNVDDTGSGPKKTDYWIDIYYSKDTKAAINYGVVKLSYTYST
What are the official names of this protein?
B-enzyme, Lysozyme.
Protein: MASTR_MOUSE
Sequence: MTLAASSQRSQIIRSKFRSVLQLRIHRRNQDCTSDSDPWISASGPALAPALPTVPASFLVSPGVLSPEPAYCPWRAPKKESPKNSQHWKEPKVRGNLTYHLYMPPEQRQGPRANLQVERSTLGPPDPPLWEKNSQRPHPRMKPSSAGVSSPSPPSHKLELQTLKLEELTVSELRQQLRLRGLPVSGTKAMLLERMRGGTPPRERPKPRREDKEAAAPWPRLKPKALGTTRLPSTVKASATNRRLKFSGATDPLGAAPAPASVPAPTPSPALAPTPTPAPVPAPAPAPFPTPPASLTLEEELQEAIRRAQLLPNRNIDDILEDQVEPDDLLPPVPLDFPGSFDLLSPSPDSEGFSSVFSSSLPSPTSSLSPSPRALTDSLDWLEALSGGPPLGSGPPGPSIFSADLSDPSGSLLWELLPDPW
What is the function of this protein?
Transcriptional coactivator.  Stimulates the transcriptional activity of MEF2C.  Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation.
What are the official names of this protein?
MEF2-activating motif and SAP domain-containing transcriptional regulator, MEF2-activating SAP transcriptional regulatory protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTBP_MOUSE
Sequence: MDRYLLLVTWREGKFRSVAGGEIEPGTEATSLESTDKQPDLTATNIYHLLKRSISDSIHPDDSTFPACSVGGTPHSRKWFFAVQAICGFYQFCSSDWQEIHFDAEKDKIEDVLQANIEECQSAVECFEEDDSNSRESLPLADLYEESAENLHQLSDKLPAPGRAMIDIILLPSDKDPPKLKECLPIVGALKHLKEWHSAKVIIAGSYCEINCQKIAEYLSASVVPLEEFRNAIDPRELWRGEIQMRERKFGFEISFPEFCLKGVTPTNVSAYNLNTCFLAKKIASSKVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELEVTGHCTRQNSMLLLEQISSLCGKVGALFVLPCTVSNVLIPPPSQLASRKWKEYMAKKPKTISVPDVAVKGEFSGYHLLLQGMGKRKCRATLLHSASQINGSFALSVIHGKMKTKAGEARPSFPFDFSSLPRFSEEQVLQREKQLASFQVLALKECLKRRKAANQPEAFSADELKSLLALTRERFLGHFDVLPTEAALAQTDTVKAAGVVNDDGTVEPYSSSLMETNPLEWPERHVLQNLETSEKAKQKMRTGSLPRSSEQLLGHKEGPRDSLTLLDAKELLKYFTSDGLPVGDLQPLHIQRGEKPFVLTPELSPGKLQVLPFEKASECHYHGIEYCLDDQKALERDGGFSELQSRLIRYETQTTCTRDSFPVPTVLSPLPSPAVLSEPQSVPEGEALQGELRTEVSGLKRRSKDPSCLYPQKRLTRSESSDCLPSQASCNSNHHHHTGKPRKPQAERCVSGLPLPGREASKDTSKTSSGQKRAHESKSSKQMKESRSQKHTRMLKEVVKDTLKRHHITEAHESFTACSQRLFDISKFYLKDLKTSRGLFEEMKKTANNNVVQVIEWVVEKMSKK
What is the function of this protein?
May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells.  Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability.  This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.  Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells.
What are the official names of this protein?
Mdm2-binding protein, mMTBP.
What is the protein family that this protein belongs to?
Belongs to the MTBP family.
Protein: RS4_ROSCS
Sequence: MARYIGPVGKISRRLGIGITEKGQRILAKRPFPPGQHGPSARRRQVSDYGLQLLEKQKARYIYGVLERQFRRIFEKAQRFPGETGAYLLILLERRLDNVVYRLGFATTRAQARQLVTHGHITVNGRKTNIPSYTVRVGETIAVRPESRRRMYFKNLVESGALAKHKAPDWLRLNPADLSGEVVAMPRREDAEPGINEQLIVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SYS_ALCBS
Sequence: MLDIRALRQDGEAIKAALSKRGYTLDLEEFAALDAKRKQADMRSQELQADRKKASKQVGELIKSGMAVDEAKAQVADALQTIDTELDKEVASAKAIQDEIREYLMGIPNVPQEAVPAGNDEDDNVEVRRWGTPKTLPFEPKDHVDIGEALEGGLDFERAAKLSGARFAVMSGGLARMHRALIDFMLDIHSDEHGYQEVYVPFLVGPEALRGTGQLPKFAEDLFKIEGERELYLIPTAEVPVTNLAADEILEANTMPRRYTCHTPCFRSEAGSHGRDTRGMIRQHQFEKVELVQMVRPEESDAALEALTGHAEAILQKLDLPYRVVILCGGDLGFSSSKTYDIEVWLPSQQCYREISSCSNFRDYQSRRMQARWRNPETGKPELVHTLNGSALAVGRTLVAILENYQNDDGSVTVPEALRPYMRGLERLK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MHPA_MYCSJ
Sequence: MTPATERDDTDTDVVIVGAGPVGLTLANILGLQGVRTMIVEERATLIDYPRGVGLDDEALRTFQAIGLVDKVLPHTVPNQILRFFDGNRRLLAEMAPPDARFGWPKRNGFVQPMVDAELHAGLARFPHVEVRWGHRMAECEETADGVTVRLDGDPTPVRARYLVGCDGGRSATRRLMGVSFDGTTSPTRWLVVDIANDPLGHPNSEVGADPARPYASISIAHGIRRFEFMIHADETDEQAEDPAFIHRMLGLLVPHPERVEVIRHRVYTHHSRIAGAFRKGRMFLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVDGRAGDALLDTYDVERRKHARAMIDLSTMVGRVISPTNRHVAAVRDKLIRGASVVPTLKRYVLEMRFKPMPRYEQGAVFHPEAPSPTSPAGTLFIQPRVDSRDAQNVLLDEVLGTGFAVLCWNNNPRALLGADLFDRWKALGARFVAARPLTQLHWTGHDDPDVTVIGDRTGALKGWFDAHAESVLFLRPDRCIAGACIAQRAPEVSTALFGVLHLTQGGGNGHHGADRPVLHVAQSATEPSGTVAGTP
What is the function of this protein?
Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).
What are the official names of this protein?
3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase, 3-HCI hydroxylase, 3-HPP hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: RL2_CERS1
Sequence: MALKSYKPTTPGQRGLVLIDRSELWKGRPVKTLVEGLIKTGGRNNTGRVTMWHKGGGAKRLYRIVDFKRRKFDVPAVVERIEYDPNRTAFIALVRYEDGELAYILAPQRLAVGDSVVAGVKTDVKPGNAMPFSGMPIGTIVHNVELKPGKGGQLARAAGTYAQFVGRDGGYAQIRLSSGELRMVRQECMATVGAVSNPDNSNQNFGKAGRMRHKGVRPTVRGVAMNPIDHPHGGGEGRTSGGRHPVTPWGKGTKGNRTRKSKASDKLIVRSRHAKKKGR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PELF_ASPFC
Sequence: MKTAVLSLFLALQTYARVTGSPSGFAAGTTGGGSATPAAPSSLDELVQWITDDKPRVILIDRTWDFIGTEGTTTGKCCSMPSTTVCSGGTSKGQAWIQDHCDGGSWVSCKYDNAALTPLDVGSNKSIVGVGNKGVIKGKGLRVRNGNKNVIIQNIHITNLNPQYVWGGDAITLDNADKVWIDHNKISLIGRQFIVSGWGKAGHVTISNNEFDGRTSWSAGCNGKHYWTLLLLGEQDYYTFQGNWLHDVSGRAPHMGTDHTKSQIFFHGVNNYFQNVGGHAFDVDTNTWVLLEGNYFENVNTPLTDTSLRAGGKLYTTSTVAAAGACQDKLGYICEWNRLAGSGAWKDRTDADVKTKAAAFKSSLVGHYPVADVPAKVVANAGVGKL
What is the function of this protein?
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins (By similarity).
What are the official names of this protein?
Probable pectin lyase E, PLE.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HERA_SULTO
Sequence: MIIGYVVGSATTQEANVLLEKKVRSGYYVTLEYDDEKVLGLVTLITTGSPLVDDSLNDIELVQRIKQMGNKIPIYMKAKVKLLCKLDGKLSQPDLPPVAGTPVRLATNEELSTIFSEGTIRIGKLIGSDVEVRIRVNALTRHLAILAATGSGKSNTVAVLSSRLSEVFGSVLIFDYHGEYYESEIKNLNNIEPKINPLNLTPDEFATLLEIRENATIQYRILRRAFKSFLEETKEKLKNGNVNYNELNNNFRNLILKKVDEVSKNEKRKDSKDEVINKIEDFLDRYSEIIDFTAGDVVDKIKIGKVNVINLSSLDEDAIDAIVSHYLRKILTSRKENKMKRKIGLKFPVLVVIEEAHVLLSKDSNTLTKHWAGRIAREGRKFGVGLIIVSQRPKGIDENILSQMTNKIILKMVEPSDKKYVLETSDNLSEDIVEGLSALDTGEAVIVGNIVRMPAIVKIDKFEGKLAGSDPNLIEEWKKAKEEIEEHADVLNWGE
What is the function of this protein?
Involved in DNA double-strand break (DSB) repair (PubMed:18243819).  Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity).  Exhibits DNA-dependent ATPase activity and DNA helicase activity (PubMed:18243819).  Loads on either a 3' or a 5' DNA tail for subsequent DNA unwinding (PubMed:18243819).  Can also unwind blunt-ended dsDNA, Holliday junction and splayed-arm DNA (PubMed:18243819).
What are the official names of this protein?
DNA double-strand break repair helicase HerA, StoHerA.
What is the protein family that this protein belongs to?
Belongs to the HerA family.
Protein: MED7_ASHGO
Sequence: MSDSNNISSLYPPPPPYVKFFTKDNLERLAEYQSSHVTTDPEQITCELDFLIPPPVPSAGHYRAFGSVWQVKDELPDLETVGLRNLYDDRGQHGNNYQYKIKELHKLLKSLLLNMLELVSVLSVNPERFPDKVEHIRTILFNIHHLLNEYRPHQSRESLIMLLEEQLEHKKEEIANIHAICDKVQAKLAAMCKQYIADD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 7, Mediator complex subunit 7.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HISZ_BURTA
Sequence: MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGNELRLRTFKLVDQVSGRTLGLRADMTPQVARIDAHLLNRQGVTRLCYAGPVLHTRPRGLHASREQLQIGAEIYGHAGLEADQEIQQLMLDALHLAGLKKIRLDLCHAGVLAALFARDAAAAGRGEALYEALAGKDVPRLNELTDDLGADTRAALRALPRLYGDASVLDEARRQLPALPEIARALDDLAHLASQVKDAEVAIDLADLRGYAYHSGAMFAAYVDGVPNAVAHGGRYDHVGQAYGRARPATGFSLDLREIARISPVEARGAAILAPWKQDDALRAAVGALRDAGEVVIQALPGHDHVLDEFACDRALVERDGAWVVEPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSME2_MOUSE
Sequence: MAKPCGVRLSGEARKQVDVFRQNLFQEADDFLCTFLPRKIISLSQLLQEDSLNVADLSSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGYLPGNEKLLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY
What is the function of this protein?
Implicated in immunoproteasome assembly and required for efficient antigen processing.  The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
What are the official names of this protein?
Proteasome activator complex subunit 2, 11S regulator complex subunit beta, REG-beta, Activator of multicatalytic protease subunit 2, Proteasome activator 28 subunit beta, PA28b, PA28beta.
What is the protein family that this protein belongs to?
Belongs to the PA28 family.
Protein: DAPB_PHOPR
Sequence: MVRIAIAGAAGRMGRQLLKATVNSEKAALGVATERSESTLIGVDAGELAGIGNVSIAIVDDLAKAANDFDVLIDFTAPVVTLANIELCKQYGKKIVIGTTGFSEEERVLIDLAAKDIAIVMAPNYSVGVNLVFKLLEKAAKVMGGYTDIEIIEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTRDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVRAAVWLADNQSGFYTMQDVLGLDDL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_PECGU
Sequence: MARYKFNPENPNRVCKAKGTNFRVHYKNTSETGRAIKGMHLHKARSYLSNVVEHKQCIPFRRHKGGVGRCAQAKNFNTTQGRWPKKSCEFMLQLLKNAESNAELRGLDVDSLVVAHVSVDAAAKMRRRTYRAHGRINPYMSSPCHIELCLEERDRVVPKGDIKTAAKKQSAKKLKKQKMMYRE
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SYA_METS3
Sequence: MLEIFDKLGYKKQKCKTCGHEFYAQVDRDTCGDAPCDEYEFIGNPATDKPYTLYEIQQVFREFLEKEGHTPIKRYPILAKRWRDDVFLVGASIFCFQPWVTSGMVKPPANPLEIEQPSVRLNDVDNVGRTGRHMTCFTMGSHTVINTEENFIYWEDETIRLCHEFFKYIGINTEEICFIKSWWSGGGNEGPCYEVCVRGVELATLVFIQYKTLDNGEKEEIPIKVVDTGYGLERIAWISQGTPTAYDACFAPVVDKLKELTDVKVNTDILARNAQIAGMMDIEDIGDIKELRQQVANSLGITLDELLESAEPMEAIYIIADHTRCLAFMLADGIIPSNVKEGYLARLVLRRTIRFMKELNMKESLAEVMGIQLEFLTKFYPEIKDSEDHIMNIISLEEERYQSTIKKGTSIVKRSIKRLKKEGKTEMPLDMLMDLYDAHGIPPETVVEIAGDNFTVNVPDNFFTLVAGAHEKDTSNKKESFEIDYPETDLLFYKDFNQKEFEAEVLGVVEKDGKNTLVFDKTVFYPEGGGQPSDVGTISVDGAVVNINYAEKVNNVVLHHVDGDVDLDNFVGKKVEGKIDWNRRITLARHHSATHLIVAAARKILGEHIWQAGAQKGVSRSRIDLSHYKRISQEELNEIEKLANEYVMDNIELDIKFYTRDEAESLYGFKLYQGGIVPGKSIRVVKIPGIDVQACAGTHVLRTGDIGPIKINKTERVQDGVERIDFSAGTAAVDSIQNENKLLRESSGIFKVDDDQLPKTCDRFFSEWKAQKNEIDKLKSEIASLKMNSLADDVTEINGLKVVKQLIDADFKELQKIATDFTDNDKADVVLMGNNDGKIVGAASQNAIDAGIKVNEIIKKAAGVLGGGGGGRLTLAQGAGPKCENMNEALNIAIDLI
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KR87P_HUMAN
Sequence: MEANSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALTQEIDFLRRLYEEEIRVLQSHISDTSVVVKMDNSRDLNMHCVITEIKAQYDDIATRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLAWTLRSPPTGACWRARSRGCVRALVL
What are the official names of this protein?
Putative keratin-87 protein, Keratin, hair, basic pseudogene 4, Keratin-121 pseudogene.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: SPX2_OCEIH
Sequence: MTVNIYGASCSSTRKARQWFKKHGIAYKERNILRQPLTINELQEILRMTVEGTDEIISTRSKIFKELNLNLDELPLQKLLELIHEHPRLLKSPILMDEKRFQVGYHEDDIRQFLPRKTREHLWLQWKLDLGLVKG
What is the function of this protein?
Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes.  Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP).  This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
What are the official names of this protein?
Global transcriptional regulator Spx 2.
What is the protein family that this protein belongs to?
Belongs to the ArsC family. Spx subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T1M1_ECOLX
Sequence: MKMTSIQQRAELHRQIWQIANDVRGSVDGWDFKQYVLGALFYRFISENFSSYIEAGDDSICYAKLDDSVITDDIKDDAIKTKGYFIYPSQLFCNVAAKANTNDRLNADLNSIFVAIESSAYGYPSEADIKGLFADFDTTSNRLGNTVKDKNARLAAVLKGVEGLKLGDFNEHQIDLFGDAYEFLISNYAANAGKSGGEFFTPQHVSKLIAQLAMHGQTHVNKIYDPAAGSGSLLLQAKKQFDNHIIEEGFFGQEINHTTYNLARMNMFLHNINYDKFDIKLGNTLTEPHFRDEKPFDAIVSNPPYSVKWIGSDDPTLINDERFAPAGVLAPKSKADFAFVLHALNYLSAKGRAAIVCFPGIFYRGGAEQKIRQYLVDNNYVETVISLAPNLFFGTTIAVNILVLSKHKTDTNVQFIDASELFKKETNNNILTDAHIEQIMQVFASKEDVAHLAKSVAFETVVANDYNLSVSSYVEAKDNREIIDIAELNAELKTTVSKIDQLRKDIDAIVAEIEGCEVQK
What is the function of this protein?
The subtype gamma methyltransferase (M) subunit of a type I restriction enzyme.  The M and S subunits together form a methyltransferase (MTase) that methylates A-3 on the top and bottom strand of the sequence 5'-GAAN(7)RTCG-3'.  In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site.  Whether the DNA is cut or modified depends on the methylation state of the target sequence.  When the target site is unmodified, the DNA is cut.  When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated (PubMed:12654995, PubMed:32483229).  After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage (Probable).
What are the official names of this protein?
Type I restriction enzyme EcoR124II methylase subunit, M protein, Type I methyltransferase M.EcoR124II, M.EcoR124II, Type I restriction enzyme EcoR124/3 methylase subunit.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: IF2B_THEKO
Sequence: MSEKVDFYDFEKLLDKAYEELPENVKHHHSRFEVPPAQVTIAGNRTIIENFVDIAEAMNRDPNHLLKFILREVATAGTLEGRRAILQGRFTPYLIANKMKKYLKEFVICPVCGSPDTKIIKKGRFHFLKCEACGAETPIQHL
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit beta, aIF2-beta, eIF-2-beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: FOLD_GLOC7
Sequence: MVSQAAKILDGKALAQKIQLSLKEEIQTLQPKIGRPPGLAVLMVGDNPASAVYVRNKEKSCTKVGMASFGRHFPGETSQSELEQVIEELNQDSRVDGILIQLPLPDHLDGIALLHQINPEKDADGLHPTNLGRLVRGEPGLRSCTPAGVMALLEEYNLEVKGKHAVVIGRSILVGKPMGLMLLEENATVTIAHSLTQNLTELTRSADILVAAAGKANLITPEMVKPGAVVIDVGINRIEDESGKARLVGDVDYEGVAEVAQYITPVPGGIGPMTVAMLLSNTVYSYRQKEAGVERQKAGGN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SDHD_ECOLI
Sequence: MENAKMNSLIAQYPLVKDLVALKETTWFNPGTTSLAEGLPYVGLTEQDVQDAHARLSRFAPYLAKAFPETAATGGIIESELVAIPAMQKRLEKEYQQPISGQLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALEAGLLTLDDDYSKLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEQDYGVAVEEGRKAAQSDPNCFFIDDENSRTLFLGYSVAGQRLKAQFAQQGRIVDADNPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCFFAEPTHSPCMLLGVHTGLHDQISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGFYTLSDQTMYDMLGWLAQEEGIRLEPSALAGMAGPQRVCASVSYQQMHGFSAEQLRNTTHLVWATGGGMVPEEEMNQYLAKGR
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.