PharMolix/UniProtQA huggingface dataset:
Protein: LPXH_SODGM
Sequence: MSTLFVADIHLCAQEPAITAGFLHFLRTRAIAAQALYILGDLFEVWIGDDDPNPLHHEIAVALQALTQRGIPCYFIHGNRDFLLGKRYAAACGITLLPAQRVMQLDELRVVILHGDTLCTDDNDYQRFRRRVHQRWLQRLFLSLPLQLRLRIADRMRANSLRANAGKTADIMDINAQAVMAVMDDTGATVMIHGHTHRPAIHQLPGERRRAVLGAWHHQGSAIEVSTSGVMLHEFSFGG
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NAGB_STRPQ
Sequence: MKIIRVQDQIEGGKIAFTLLKDSLAKGAKTLGLATGSSPISFYQEMVKSPLDFSDLTSINLDEYVGLSVESDQSYDYFMRQNLFNAKPFKKNYLPNGLATDIEAEAKRYDQIIAEHPIDFQVLGIGRNGHIGFNEPGTSFEEETHVVDLQESTIEANSRFFTSIEDVPKQAISMGIASIMKSKMIVLLAFGQEKADAIKGMVFGPITEDLPASILQKHDHVIVIVDEAAASQLD
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: HYPK_HUMAN
Sequence: MATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALIALTN
What is the function of this protein?
Component of several N-terminal acetyltransferase complexes (PubMed:20154145, PubMed:29754825, PubMed:32042062).  Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) (PubMed:29754825, PubMed:32042062).  Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex (PubMed:17947297, PubMed:20154145).  May play a role in the NatA complex-mediated N-terminal acetylation of PCNP (PubMed:20154145).
What are the official names of this protein?
Huntingtin-interacting protein K, Huntingtin yeast partner K.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Within the NatA/HYPK complex, may localize to ribosomes.
Protein: ITPK4_ARATH
Sequence: MKGVLLDESVLFSPESEDSSPSLRESVPSLLRLLRYSMIRTGISYGLDLPENKVDLLRKTAAEYSINCLPLETSLTSVTFGDTLKAWYSDGSILYVASSRKEEILRELSPSQLVVLLDVEGDSLEDPNIIHIHSLEELPMTICCINKKAMGDGAAIVAYIMKPSRVEDFAKRGALPMYPTSCGLIFLPLMFEFPLASQLKHADIIFHKATDEILSIELNCSDSKSSVAVTFSTGMEKLKKYMEDQNACAIVDPIRNIYPVVDRLKMQHILLGLEGLGAAGRKIRGACFLKIDSYDEPDLAQNLSRAGLSLPCIVKPQVACGVADAHSMAIVFRVEDFKNLNTPVPAIIQEYVDHSSRIFKFYVLGETIFHAVKKSIPSSSSLRKSAEENGLKPILFDSLKSLPVDSANQNPVSEIDLELVTEAATWLRKKLDLTIFGFDVVIQEGTGDHVIVDLNYLPSFKEVPDNIAVPAFWEAIRNRFDQHVQEKH
What is the function of this protein?
Kinase that can phosphorylate the inositol polyphosphate Ins(1,3,4)P3 to form InsP4.  Also phosphorylates a racemic mixture of Ins(1,4,6)P3 and Ins(3,4,6)P3 to form InsP4.  Does not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity, but possesses inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity (PubMed:17698066).  Ins(1,3,4,6)P4 is an essential molecule in the hexakisphosphate (InsP6) pathway (By similarity).
What are the official names of this protein?
Inositol 1,3,4-trisphosphate 5/6-kinase 4, AtItpk-4, Inositol-triphosphate 5/6-kinase 4, Ins(1,3,4)P(3) 5/6-kinase 4, Inositol-tetrakisphosphate 1-kinase 4.
What is the protein family that this protein belongs to?
Belongs to the ITPK1 family.
Protein: SPEB_SALDC
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHHRFPWSFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLSAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPHHSVQIGIRTEFDKDNGFTVLDACQVNDRGVDDILAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: 14KL_BRUAB
Sequence: MNSFRKTCAGALALIFGATSIVPTVAAPMNMDRPAINQNVIQARAHYRPQNYNRGHRPGYWHGHRGYRHYRHGYRRHNDGWWYPLAAFGAGAIIGGAISQPRPVYRAPAGSPHVQWCYSRYKSYRASDNTFQPYNGPRKQCRSPYSR
What is the function of this protein?
Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose.  Essential for virulence.  May be involved in LPS biosynthesis or polysaccharide transport (By similarity).
What are the official names of this protein?
Lectin-like protein BA14k.
What is the protein family that this protein belongs to?
Belongs to the BA14k family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ATPD_PENGL
Sequence: KIANGSGSEQDIAEAKI
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element.  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
What are the official names of this protein?
ATP synthase subunit delta, mitochondrial, F-ATPase delta subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: PMK1_MAGOR
Sequence: MSRANPPSNSSGSRKISFNVSEQYDIQDVVGEGAYGVVCSAIHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRSYETFNEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQENNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKVPFRTLFPKTSDLALDLLEKLLAFNPVKRITVEEALKHPYLEPYHDPDDEPTAPPIPEEFFDFDKHKDNLSKEQLKQFIYQEIMR
What is the function of this protein?
Mitogen-activated protein kinase; part of the MST11-MST7-PMK1 MAP kinase (MAPK) cascade that is essential for appressorium formation, penetration and invasive growth (PubMed:8946911, PubMed:11952120, PubMed:15749760, PubMed:21283781, PubMed:23085322, PubMed:23454094, PubMed:27059015).  Central regulator of appressorium development that acts downstream of the cAMP signal (PubMed:8946911, PubMed:23591122).  The MST11-MST7-PMK1 MAP kinase cascade transduces signals from the cell surface sensors MDB2 and SHO1 that recognize various surface signals such as surface hydrophobicity, cutin monomers, and rice leaf waxes (PubMed:21283781).  Regulates expression of secreted fungal effector proteins implicated of host immune defenses, preventing reactive oxygen species generation and excessive callose deposition at plasmodesmata (PubMed:29567712).  Furthermore, controls the hyphal constriction required for fungal growth from one rice cell to the neighboring cell, enabling host tissue colonization and blast disease (PubMed:29567712).  Targets downstream of the PMK1-MAPK pathway include transcription factor MST12 and pathogenicity-related genes GAS1 and GAS2, both of which are expressed during appressorium formation, even if regulation of MST12 is not associated with expression of GAS1 or GAS2 (PubMed:12215509, PubMed:11952120, PubMed:23454094).
What are the official names of this protein?
Mitogen-activated protein kinase PMK1, MAPK PMK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: TPIS_PYRIL
Sequence: MKFPILIINLKAYGEAAGKKALEIAKAAEKVAKELGVNIAVAPNHLELALVAQSVEIPVYAQGADVETPGAYTAHIAVDNIKAVGASGLILNHSEAPLALNQLSKLAARAKSIGLDVVICAPDPVTSLAAAALGPHAVAVEPPELIGTGKAVSKYKPETIIETVRLVTKHFPNVVVITGAGIETGEDVEAALKLGTKGVLLASAAVKAKDHYQKIFELAKPLTVAAEPP
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSLN_HUMAN
Sequence: MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA
What is the function of this protein?
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
What are the official names of this protein?
Mesothelin, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor.
What is the protein family that this protein belongs to?
Belongs to the mesothelin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. SUBCELLULAR LOCATION: [Megakaryocyte-potentiating factor]: Secreted. SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Protein: Y4755_DICDI
Sequence: MIINFLLNSIVGTVKLDENPNINLKNNINNNDNNKENSIEINDYLQTLVKEEDFKNQHTDPNFKFLALRSTKVPIDEYNPENYQLKFVQIITRHGRRTPESKRYPLTMWTCNSLDQLITNKDTSRPDCNMGQLTVLGIVDQINVGKAYRNLFINNLHFLDNKYNKDQIFIRSSNRERTISSARSFMHGLYGGSFADDQEKSPNHSSFLILDEKDENMYPRSSPKYNFLKGLLKKHKAVIEENEKSNLKEFTEKIKNIFEDSKFDTAFYVPSWRSYAGLVNSFDCFRNNGLPLPKGFTNDVIQRMYEESAKEFKSARLFPEMSILGIGRFVNDLTKQMYLKSVNDPSVKDLKLSLYSGHDTTLAALLVAYDMYEDNVHPVTSSALEYLLFQDKNYKEPEVVTKSNEKELINHQYVKVIFNHKPIHIGPCKDKEVDGMCPLSEFLKISQSIIPTNYDEQSKITDEEKNKYIQEST
What are the official names of this protein?
Probable acid phosphatase DDB_G0284755.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family.
Protein: RS15_ROSS1
Sequence: MALEKDEKTAIIADYQMHSTDTGSPQVQVALLTERINGLIEHLKVHPHDHHSRRGLLKLVGRRRRLLAYLASRDKEAYRKLIDTLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: ATPF_ACISJ
Sequence: MSINATLFVQAIVFLILVLFTMKFVWPPITKALDERAQKIADGLAAADRAKTELAAADQRVKQELAAASNEIATRLADAERRAQAIIEEAKARANDEGNKIVAAARAEAEQQAIQAREALREQVAALAVKGAEQILRKEVNAGVHADLLNRLKTEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RF2_ECOSM
Sequence: MFEINPVNNRIQDLTERSDVLRGYLDYDAKKERLEEVNAELEQPDVWNEPERAQALGKERSSLEAVVDTLDQMKQGLEDVSGLLELAVEADDEETFNEAVAELDALEEKLAQLEFRRMFSGEYDSADCYLDIQAGSGGTEAQDWASMLERMYLRWAESRGFKTEIIEESEGEVAGIKSVTIKISGDYAYGWLRTETGVHRLVRKSPFDSGGRRHTSFSSAFVYPEVDDDIDIEINPADLRIDVYRASGAGGQHVNRTESAVRITHIPTGIVTQCQNDRSQHKNKDQAMKQMKAKLYELEMQKKNAEKQAMEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVETRNTQAVLDGSLDQFIEASLKAGL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_BACCN
Sequence: MLNIEQIKEIIPHRYPFLLVDQVLEVEEGKRAVGIKNVSANEEFFNGHFPEYAVMPGVLIVEALAQVGAIAILKKEENRGRLAFFGGIDHCRFKKQVRPGDQLRLEVELTRVRGPIGKGKAVATVDGEIVCEAEITFALGEKKE
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXEC1_ARATH
Sequence: MPSLSTPPSQNLAFSPAASATSSRLTPSSKRSFYPHRLPDPTALCRCSSSSGSNSSSSSSSDDNPRWDSAIQDVLKSAIKRFDSVLSWYATLDNDDGEQGSENVEKIDDDWDWDRWKKHFDQVDDQDRLLSVLKSQLNRAIKREDYEDAARLKVAIAATATNDAVGKVMSTFYRALLEERYKDAVYLRDKAGAGLVGWWSGISEDVKDPFGLIVQITAEHGRYVARSYNPRQLSTSAAGAPLFEIFLTLDGKGNYKKQAVYLKWKEIFPDVPTMPSRTLTPGRFLTSPGRKEDTGNLAVESSEDEESDNSDDDSDLLEESSGFQSFLRDMIPGVKVKVMKVTAPGRVDKDFISKVIEQIADEEDEENDLDIEDIDVEDDTKAEIDEKNADIELESVTDEIIDNNGGREIAVKFVIGDIVDRLSGNQPLKESLRSPANLESVENSSFYLRLEKDLNVKESKGVEGTTLVDGKGSRQSRRRIENIMGDLAKSIEKEKKISVKMLKDVGELLSLTLSQAQNRQQLSGLTKFRRIDVTPSLDPLDGLYIGAHGLYTSEVIHLKRKFGQWKGGKESKKPTDIEFYEYVEAVKLTGDPYVPAGKVAFRAKIGRRYELPHKGLIPEEFGVIARYKGQGRLADPGFRNPRWVDGELVILDGKYVKGGPVVGFVYWAPEYHFVMFFNRLRLQA
What is the function of this protein?
Together with EX2, enables higher plants to perceive singlet oxygen as a stress signal in plastid that activates a genetically determined nuclear stress response program which triggers a programmed cell death (PCD).  This transfer of singlet oxygen-induced stress-related signals from the plastid to the nucleus that triggers genetically controlled PCD pathway is unique to photosynthetic eukaryotes and operates under mild stress conditions, impeding photosystem II (PSII) without causing photooxidative damage of the plant.
What are the official names of this protein?
Protein EXECUTER 1, chloroplastic, AtEX1.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MREB_PASMU
Sequence: MLFKKIRGLFSNDLSIDLGTANTLIYVKGQGIVLDEPSVVAIRQERSGALKSIAAVGRDAKLMLGRTPKSIAAIRPMKDGVIADFFVTEKMLQYFIKQVHSSNFMRPSPRVLVCVPAGATQVERRAIKESAIGAGAREVYLIEEPMAAAIGAKLPVSTATGSMVIDIGGGTTEVAVISLNGIVYSSSVRIGGDRFDEAIISYVRKTFGSIIGEPTAERIKQEIGSAFIQEGDEVREIEVHGHNLAEGAPRSFKLTSRDVLEAIQAPLNGIVAAVRTALEECQPEHAADIFERGMVLTGGGALIRNIDVLLSKETGVPVIIADDPLTCVARGGGEALEMIDMHGGDIFSDDI
What is the function of this protein?
Forms membrane-associated dynamic filaments that are essential for cell shape determination.  Acts by regulating cell wall synthesis and cell elongation, and thus cell shape.  A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
What are the official names of this protein?
Cell shape-determining protein MreB.
What is the protein family that this protein belongs to?
Belongs to the FtsA/MreB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Membrane-associated.
Protein: Y4259_DICDI
Sequence: MSQKLSFFQQNTRNGSGASRTLVIKPPTIQPKPENSISKTFSK
What are the official names of this protein?
Putative uncharacterized protein DDB_G0281869.
Protein: RCNR_ECOUT
Sequence: MSHTIRDKQKLKARASKIQGQVVALKKMLDEPHECAAVLQQIAAIRGAVNGLMREVIKGHLTEHIVHQGDELKREEDLDVVLKVLDSYIK
What is the function of this protein?
Repressor of rcnA expression.  Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt.  In the presence of one of these metals, it has a weaker affinity for rcnA promoter (By similarity).
What are the official names of this protein?
Transcriptional repressor RcnR.
What is the protein family that this protein belongs to?
Belongs to the FrmR/RcnR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERBIN_HUMAN
Sequence: MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS
What is the function of this protein?
Acts as an adapter for the receptor ERBB2, in epithelia.  By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728).  Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728).
What are the official names of this protein?
Erbin, Densin-180-like protein, Erbb2-interacting protein, Protein LAP2.
What is the protein family that this protein belongs to?
Belongs to the LAP (LRR and PDZ) protein family.
What are the subcellular locations of this protein?
Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).
Protein: RPOB_LEGPH
Sequence: MAVAEAKPQYSHAEKKRFRKSFGKQTDIMPIPNLLEIQLKSYRDFLQTDTKLSEQLNTGLHAAFSSVFPIESFSGNARLEYVGYKLGEPAFDVRECKLRGLTYSAPLRVKIRLVVLDKDASDDPKPIKDIREQDVFMGEIPLMTDVGTFVVNGTERVVVSQLHRSPGVIFEHDKGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDCVYVRIDRRRKLPVTILLRALGYEAEDILSEFFETTHCHLKNGEYHIDLIPQRLRGEIASFDIHVPETGELIVEQGRRITARHIKQMEKSQMQDLVVPRDYLIGKTLAKNIIDTSTGEFLAQANDEITEELLDAMANHGILQIDMIYTNDLDHGSYISDTLKIDPTGSQLEALVEIYRMMRPGEPPTKEAAEALFKNLFFVEERYDLSAVGRMKFNRRVGIKSDEGPGTLTKEDILSVIKTLIDIRNGIGMVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSLVESENLMPQDLINAKPVSAAIKEFFGSSQLSQFMDQVNPLSGVTHKRRVSALGPGGLTRERAGFEVRDVHTTHYGRVCPIETPEGPNIGLINSLSVYARTNEYGFIETPCRKVVNGRVTDEVEYLSAIEEVDQYIAQSNVELDAQGNILADLVPCRHQNEFSLTTPDKINYMDVSPKQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRSEKPLVGTGMERIVASDSGVSVVAKRGGVIDLVDASRIVVRVNDDETTAGETGVDIYNLTKYFRSNQDTCINQRPIVSTGDRIQRGDVLADGPCTDMGELALGQNLLVAFMPWNGYNFEDSILISERIVHDDRFTTIHIEELTCIARDTKLGTEEITADIPNVGESALSNLDESGVVYIGAEVKAGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPSGMNGTVIDVQVFTRDGLEKDARAKSIEEEHLARVRKDLIDERRIREEDIYHRVSHLLLDKVATGGPGSLKPGSKITQDYLDKVEREKWFDIRIEDDAISQQLEQLSKQLELLTKEMEKRFNDSRKKIIQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISIVVPVEDMPHMEDGTAVDIVLNPLGVPSRMNIGQVLETHLGLAAKGLGRKIAQMLDEKQTPEAIKAYLEKIYNHDGVQRVNLKCLNDDELMTLADNLRAGVPMATPVFDGATEQEIKSMLQLADLPADGKTVLIDGRTGNKFDNPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVGGRTKIYKNIVDGDHRMDPGMPESFNVLLKEIRALGIDIELEHD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: G3P_SERMA
Sequence: IVFRAAQERSDIEIVAINDLLDAEYMAYMLKYDSTHGRFNGTVEVKDGHLVVNGKTIRVTAEKDPANLKWNEVGVDVVAEATGIFLTDETARKHITAGAKKVVLTGPSKDATPMFVRGANFDKYAGQDIVSNASCTTNCLAPLAKVINDNFGIVEGLMTTVHATTATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVIPELKGKLTGMAFRVPTPNVSVVDLTVRLEKPATYEEIKKAMKDAAEGSMKGVLGYVEDDVVSTDFNGEVLTSVFDAKAGIALNDNFVKLV
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRGA_BACC3
Sequence: MSTKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVIKLEQVESLGTALTGIIGFLFVPSGISVINSLGVMGQYFVQILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVVNKGRKHGKVA
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA.  The LrgAB and CidA proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgA.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. LrgA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y435_PROMA
Sequence: MNQFESTQSNIFSLRSSDRCNVFGSSSSSPSLLNRWIDIWSTSISDITSILVLAGTKTAEIEGISAAGATKESRRFTAVADAEFLLHGPTASRRWPLPPLSAGVSPALISYVASDLIGVKSLIAQAGILQTPSFPCLSIESPSQGPSECITTGKAMDINRVENLFEEGMKMGLELASPLLLTECVPGGTTTALAVLTGLGITASELISGSSRTPPMTLKKKIVEKGLQSLSLGAKPCPKELLAAVGDPFQPFAVGLLLGARKVKQPVLLGGGSQMLAVLATALASIDSSLKDDFVEDISIGTTYWLANESLSLSIGQSAFQSLIKLVEDSFEVSLLGLSAGLRFTKSSKQVLRDYEIGYVKEGVGAGAFVLLAQNNGVSCKKLIEECEFAVDQLDKI
What are the official names of this protein?
UPF0284 protein Pro_0435.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.