PharMolix/UniProtQA huggingface dataset:
Protein: PDXJ_COLP3
Sequence: MSELLLGVNVDHIATLRQARGTNYPDPVYAASVAEHAGADGITVHLREDRRHIQDRDIHVLKQTLHTRMNFEMAVTDEMIAIACDVKPVFCCLVPEKREELTTEGGLDVVGQLDKITKATEQLTAAGIAVSLFIDADKAQIDAAVASKAPYIEIHTGHYADLSSEEEQLIELERLTVGIKYAHNLGLKVNAGHGLNYFNVKPIAAIKEIIELNIGHAIIARAAIDGLDKAVRDMKQLMLEARTYNT
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISDF_STAAC
Sequence: MMIKNKKKLLFLCLLVILIATAYISFVTGTIKLSFNDLFTKFTTGSNEAVDSIIDLRLPRILIALMVGAMLAVSGALLQAALQNPLAEANIIGVSSGALIMRALCMLFIPQLYFYLPLLSFIGGLIPFLIIILLHSKFRFNAVSMILVGVALFVLLNGVLEILTQNPLMKIPQGLTMKIWSDVYILAVSALLGLILTLLLSPKLNLLNLDDIQARSIGFNIDRYRWLTGLLAVFLASATVAIVGQLAFLGIIVPHVVRKLVGGNYRVLIPFSTVIGAWLLLVADLLGRVIQPPLEIPANAILMIVGGPMLIYLICQSQRNRI
What is the function of this protein?
Part of the binding-protein-dependent transport system for heme-iron.  Responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Probable heme-iron transport system permease protein IsdF, Iron-regulated surface determinant protein F, Staphylococcal iron-regulated protein G.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SORCN_HUMAN
Sequence: MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV
What is the function of this protein?
Calcium-binding protein that modulates excitation-contraction coupling in the heart.  Contributes to calcium homeostasis in the heart sarcoplasmic reticulum.  Modulates the activity of RYR2 calcium channels.
What are the official names of this protein?
Sorcin, 22 kDa protein, CP-22, CP22, V19.
What are the subcellular locations of this protein?
Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
Protein: UTP15_BOVIN
Sequence: MAGYKPVSIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHSVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNTDLFVTGSYDHTVKMFDARTNQSVISVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYTASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKDSVPRRRRPAYRTFIKGKNYMKQQDDILINRPSKKHLELYDRDLKNFRISKALDRVLEPTCTIKTPEVTVSIIKELNRRGVLANALAGRDEKEISRVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLILQGLVEKEIDYQRELLETLGMMDMLFATMTRKESTSVLQHNTSDGFLENNKIES
What is the function of this protein?
Ribosome biogenesis factor.  Involved in nucleolar processing of pre-18S ribosomal RNA.  Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 15 homolog.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Found predominantly at the fibrillar center.
Protein: CO8A_RABIT
Sequence: MLVAAFFTLFLVTCQPAVTAQEKVNQRVNRAATPRAFDCQLSSWSEWTDCFPCQDTKYRHRSLLQPNKFGGTICSGDIWDRASCYSPTACLRPAQCGQDFQCKETGRCLKRHLVCNGENDCLDGSDEDNCEDIRATESDCAQYDPIPGSEKAALGYNILTQEEAQSVYDARYYGGRCETVYNGEWRHVRYDPVCERLHHGEDDKYFRKPYNFLKYHFEARADTGISFELYVDGNDLFSKVKNDKSHSAGVTISAGLTGSPLLGTVGVSGSEDASFLNKLSQYNEKKYNFMRIFTKVQTAHFKMRRDDIVLDEGMLQALVELPEQYNYGMYSKFINDYGTHYITSGSMGGTYEYILVLNTEKMESLGVTSEDISSCFGGFGEIQYEKGKINAQGILSGKHCKKSGSGDKEADKMGQAVKDIISRVRGGSSGWGGGLSQNGSATTYRFWGRSLKYNPVVIDFEMQPIHEVLLHTNLGHVEAKRQNLRRALDQYLMEFNACRCGPCFNNGKPILEGTSCRCQCSLGLQGPACEQTEQQGAKADGHWSCWGSWSPCTAGTRERRRECNNPAPQNGGAPCPGWRVQTQAC
What is the function of this protein?
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.  C8A inserts into the target membrane, but does not form pores by itself (By similarity).
What are the official names of this protein?
Complement component C8 alpha chain, Complement component 8 subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the complement C6/C7/C8/C9 family.
What are the subcellular locations of this protein?
Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells.
Protein: GATC_CHRSD
Sequence: MAIEHADVLRAAHLARVGLGEDEATGYVDDLSRILEMVDQLQAVDTQGIAPLAHPLDATQRLRPDEVTEHNQRERFQACAPVTEGGLYLVPRVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: BR1A_PULPI
Sequence: FMGGLIKAATKIVPAAYCAITKKC
What is the function of this protein?
Has antibacterial activity against the Gram-positive bacterium S. aureus ATCC 25923 (MIC=3 uM) and the Gram-negative bacterium E. coli ATCC 25726 (MIC=24 uM).
What are the official names of this protein?
Brevinin-1PTa.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: GCST_LISIN
Sequence: MTELLKTPIHPLYAKYGAKTIDFGGWDLPVQFAGIKAEHEAVRTDAGLFDVSHMGEILVEGPDSTSYLQYLLSNDIEKIKIGKAQYNIMCYETGGTVDDLVVYKKSETEYILVVNAANTEKDYEWMVQNIVGDVTVKNASSEFGQLALQGPNAEKILSKLTDADLSSISFFGFIEDADVAGVKTIISRSGYTGEDGFEIYMQSADAGKVFEAILAEGVAPIGLGARDTLRLEAVLALYGQELSKDITPLEAGLNFAVKLKKEADFIGKQALIKQKEAGLTRKLVGIELIERGIPRHDYPVFLNDKEIGVITSGTQSPTLGTNIGLALIDTAYTELDQELEVGIRNKKVKAKVVQTPFYKRAK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: ACPH_ECO81
Sequence: MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMAQASRKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: MA1A1_DROME
Sequence: MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFGSDRVLRVYKHFRKAGPEIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLDEPPAAGGGEPGQFQVLAQQAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQASSHPQSSAQQHNQQQPQLPLGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVTLPVSNAS
What is the function of this protein?
Involved in the maturation of Asn-linked oligosaccharides.  Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
What are the official names of this protein?
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA, Man(9)-alpha-mannosidase, Mannosidase-1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: CLAMP_BPKVM
Sequence: MKLNKSTIEVLKNFAGINNGMVIHAGSRIRTQDNLNKQIAYADIEDSFPVEFAVYDLGEFLSALNLLDNAELDFQEKFVVVTGDGGTKLTFQYANAEFVTEAPEKVNFPTELDGGAEFDLKGEDLQRVKKASATLGLSDICVRTEAGSTAITLSATDAQGSSKHTFEINVGEADVDTEFKFFFKSERLNIVDQDYKVSIHPAGISRFLGLSLEYFIATEAL
What is the function of this protein?
Sliding clamp that encircles the genomic DNA and links the DNA polymerase to the template to control the processivity of DNA synthesis.  Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.  Interaction with the sliding-clamp-loader opens the sliding clamp so that it can be loaded around the DNA template.  During transcription, encircles the DNA and tethers host RNA polymerase (RNAP) to it.
What are the official names of this protein?
Sliding clamp, DNA polymerase accessory protein Gp45, DNA polymerase clamp, Gene product 45, gp45.
What is the protein family that this protein belongs to?
Belongs to the Tevenvirinae sliding clamp family.
Protein: HUPE_AZOCH
Sequence: MSRLDLKNGSVEMVHGSGGRAMGQLIEELFARALRNQWLDQGNDQAQFELPPGRVVMATDSHVISPLFFPGGDIGSLAVHGTINDVAMAGARPCYLAAGFILEEGFPLADLARIVESMAAAAREAGVPVVTGDTKVVERGKGDGVFITTTGVGVVPPGLYLSGDRARPGDRILLSGSIGDHGVTILSLREGLGFEADIGSDSQALHGLVAAMVEAVPEIRCLRDPTRGGLGNTLNELARQSGVGMQLVERAIPLREPVRAACEFLGLDPLYVANEGKLIAICPAEQAERLLEVMREHPQGREAAIIGTVVADAQCFVQMETLFGGSRMVDWLNGEQLPRMC
What is the function of this protein?
May be involved in the maturation of the NifE hydrogenase.
What are the official names of this protein?
Hydrogenase expression/formation protein HupE.
What is the protein family that this protein belongs to?
Belongs to the HypE family.
Protein: AIFM1_RAT
Sequence: MFRCGGLAGAFKQKLVPLVRSVCVQRPKQRNRLPGNLFQQWRVPLELQMARQMASSGPSGGKMDNSVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERIMGLGLSPEEKQRRAIASAAEGGSVPPIRVPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQASGIEVIQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSDPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED
What is the function of this protein?
Functions both as NADH oxidoreductase and as regulator of apoptosis (By similarity).  In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway.  Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains.  The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i. e.  caspase-independent fragmentation of chromosomal DNA.  Binds to DNA in a sequence-independent manner (By similarity).  Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (By similarity).  Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (By similarity).  In contrast, participates in normal mitochondrial metabolism.  Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (By similarity).
What are the official names of this protein?
Apoptosis-inducing factor 1, mitochondrial, Programmed cell death protein 8.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.
Protein: RS9_BORBU
Sequence: MKKSNFSNVNLSMGTGRRKSSVARVYIREGSGNIKVNNRDFDSYIQLENLRTMALSPLVLTNTLGKYDLYINVYGGGISGQSGAIRHGISRALFKLDESNKMILRSNGFLTRDSRKVERKKFGQKKARKSFQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: ACYP_CROS8
Sequence: MAWVHGRVQGVGFRYTTQHEATRLGLTGYARNLDDGSVEVLACGEAEQVEKLIAWLKAGGPRSAHVEKVLTEPHSPTEDYQDFRIRY
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: UVRB_CLONN
Sequence: MNQFKIHSPYKPTGDQPRAIKSISEGILKGEKFQTLLGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLTSEFREFFPENCVEYFVSYYDYYQPEAYVPQTDTFIEKDASINDEIDKLRHSATSALFERNDVIVVASVSCIYGLGNPEEYKKLTVSLREGMEKDRDEIMRQLVDIQYERNEINFVRGTFRARGDVLDIFPASSTNIGIRVEFFGDEIDKIREFDVLTGNIISARKHALIFPASHFATSKDKLEIAIKKIEEELEDRVKVLTAEDKLLEAQRVRQRTNFDIEMMREVGYCSGIENYSRVLDGRAPGTPPKTLMDYFPDDFLLFIDESHVTLPQVKAMYGGDRSRKNNLVEYGFRLPCAYDNRPLKFDEFEGKLNQTVFVSATPAQYELEHSTNVAEQIIRPTGLLDPEIIVKPIKGQIDDLYASIKETIDKGFRVLVTTLTKKMSEDLTDYLKSMGIKTEYLHSSIDTIKRMEIIRDLRKGKFDVLVGINLLREGLDIPEVALVAILDADKEGFLRSETSLVQTIGRAARNSESKVIMYADNITKAMDKAISETNRRRKIQMEYNDKHGIVPRTVLKDIRDVIQTKVAEDEAEYKVNNNTDKLSKKEIEKLINKYEEEMKVAAKELQFERAAELRDEILKLKEQL
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_STAAM
Sequence: MAKRDYYEVLGISKDASKDEIKKAYRKLSKKYHPDINKEEGADEKFKEISEAYEVLSDDNKRASYDQFGHDGPQGFGGQGFNGSDFGGFSGFGGGGFEDIFSSFFGGGRQRDPNAPQKGDDLQYTMTLTFEEAVFGTTKEISIRKDVTCETCHGDGAKPGTSKKTCSYCNGAGHVAVEQNTILGRVRTEQVCPKCNGSGQEFEEACPTCHGKGTENKTVKLEVKVPEGVDNEQQIRLAGEGSPGVNGGPAGDLYVVFRVKPSETFKRDGDDIYYKLNVSFPQAALGDEIKIPTLNNEVMLTIPAGTQTGKQFRLKEKGIKNVHGYGYGDLYVDIKVVTPTKLTDRQKELMKEFAQLNGEEINEQPSNFKDRAKRFFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALF1_STACT
Sequence: MNQEQFDKIKNGKGFIAALDQSGGSTPKALKDYGVEENEYSNDEEMFNLVHDMRTRIITSPAFNGEKILGAILFEQTMDREVEGKYTGSYLADKGIVPFLKVDKGLAEEADGVQLMKPIPDLDKLLDRANERGIFGTKMRSNILENNKEAIEKVVKQQFEVAKEIIAAGLVPIIEPEVNINAKDKEAIEANLAEAIKAELDNLKKDQYVMLKLTIPTKVNAYSELIEHPQVIRVVALSGGYSRDEANKILKQNDGLIASFSRALVSDLNAQQSDAEFNEKLQEAIDTIFDASVNKA
What are the official names of this protein?
Fructose-bisphosphate aldolase class 1, Fructose-bisphosphate aldolase class I, FBP aldolase.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
Protein: MPK18_ARATH
Sequence: MQQNQVKKGTKEMEFFTEYGDANRYRILEVIGKGSYGVVCAAIDTHTGEKVAIKKINDVFEHISDALRILREVKLLRLLRHPDIVEIKSIMLPPSKREFKDIYVVFELMESDLHQVIKANDDLTREHHQFFLYQMLRALKFMHTANVYHRDLKPKNILANANCKLKVCDFGLARVAFNDTPTTVFWTDYVATRWYRAPELCGSFFSKYTPAIDVWSIGCIFAEVLTGKPLFPGKSVVHQLELITDLLGTPKSETISGVRNDKARKYLTEMRKKNPVTFSQKFSKADPLALRLLQRLLAFDPKDRPTPAEALADPYFKGLSKIEREPSSQQISKMEFEFERRRLTKDDIRELIYREILEYHPQLLKDYMSGSEGSNFVYPSAIGHLRQQFTYLEENSSRNGPVIPLERKHASLPRSTVHSTVVHSTSQPNLGATDSRRVSFEPSKNGASSAGHPSTSAYPTKSIGPPPRVPPSGRPGRVVESSVSYENGRNLKEAYFRSAVSSPHCYFRPNTMTNPENRNIEASSFPPKPQNPVHQFSPTEPPAATTNQADVETMNHPNPYFQPQLPKTDQLNNNTHMAIDAKLLQAQSQFGPAGAAAVAVAAHRNIGTISYSAAS
What is the function of this protein?
Mitogen-activated protein kinase (MAPK) that is specifically regulated by PHS1 and MAPKKK20 and mediates signaling that regulates cortical microtubule functions, maybe through regulation of microtubule dynamic instability.
What are the official names of this protein?
Mitogen-activated protein kinase 18, AtMPK18, MAP kinase 18.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: HACB1_METAC
Sequence: MMKNPIIGRVWKFGDDIDTDVIIPGKYLRTKDMQIFAAHAMEGIAPEFTKKAKPGDIIVAGENFGCGSSREQAPLAIKHAGIACVVAKSFARIFFRNAINVGLPLMEADIECQEGDEIEVDLLKGEVRVPGKGVFVGNKLPDFLLDILTDGGLVSHRKKAQNEQKE
What is the function of this protein?
Component of a hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids.  Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate).  Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate.  These reactions are part of the biosynthesis pathway of coenzyme B.
What are the official names of this protein?
Methanogen homoaconitase small subunit 1, HACN 1, Homoaconitate hydratase 1.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: HISX_WOLSU
Sequence: MRKIKRLNSSLAEFRREFDELLLRGNVDMDTVIPVVSGLIKEIRTQGDAALLAHVAKFDRWNPKSAMELKIDPSLMKRAYEGLEASLREALHSAYNRIHSFHSKQKPQSWLDFEENGTILGQKVTPMDRAGLYIPGGKAAYPSSLLMNAIPAIVAGVKEIVVCTPTPENEPNELLLAACHLCGIKEVYKVGGASAIAAMAYGTESLGRVDVITGPGNIYVATAKKLVFGQVNIDMVAGPSEIGILADESAKAPWVALDLLSQAEHDEMASSILVTPSVELADAVDVEVERALERLDRKEISSKSIYTRGAIIIAKDMNEAVSLMNEIAPEHLEVLVENPFGWLPEIRHAGAIFLGENTPEPIGDYIAGPNHTLPTGGTARFYSPLSTEHFMKKSSILSFSERGIRELGHHCAKLAQTEGLDAHKESVLARLV
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: FRDC_YERPN
Sequence: MTTKRKAYVRTMAPNWWQQLGFYRFYMLREGTSIPAVWFSVLLIYGVFALKSGPAGWEGFVSFLQNPLVLFLNILTLFAALLHTKTWFELAPKAVNIIVKSEKMGPEPMIKALWVVTVVASAIILAVALL
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit C, Fumarate reductase 15 kDa hydrophobic protein, Quinol-fumarate reductase subunit C, QFR subunit C.
What is the protein family that this protein belongs to?
Belongs to the FrdC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THII_LACAC
Sequence: MEYTEVMVRYGELSTKGKNRKDFINRLATNVERVLKDFPQIEFHPRHDRMHIILNGAPFTEVDKRLKKVFGIQTYSPAIKIPKTLEDIEKTSLELMKETFKPGMTFKINTKRSDHKFEYDTNQLNNLVGDFLFDNIDNLKAEMKHPDLVLRIEVRQDAVYISNQLLHGVGGMPVGTAGKAVMMLSGGIDSPVASWLALKRGVDIEMVHFFSPPYTTEKALAKAKELTGILANYAGKINFIAVPFAEIQETIKEKLPEGYLMTVQRRFMLQLADRIRAMRGGLAIFNGESVGQVASQTLESMVAINDVTTTPVIRPVATMDKTEIIAKAEEIGTFDLSIQPFEDCCTIFAPPRPKTKPKLDKAREYEARLDVEGLIQRALDGIEVMPIYPNQKFLDDKAQEDADLL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHG_ELEEL
Sequence: NEESDLIADKFTNYNKLIRPAKH
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: NADK2_BACAN
Sequence: MADRRNLFFFYGDDKAKLVEKMKPIYRILEENGFTILDHPKNANAIVSVGDDATFLQAVRKTGFREDCLYAGISTKDEISFYCDFHIDHVDTALQEITKNEIEVRKYPTIEVDVDGSTSFHCLNEFSLRSSIIKTFVVDVHVDDLYFETFRGDGLVVSTPTGSTAYNKSLRGAVVDPLIPCFQVSELASLNNNTYRTLGSPFILNHERTLTLKLRPDGNDYPVIGMDNEALSIKQVEKAVVRLSDKQIKTVKLKNNSFWEKVQRTFL
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase 2, ATP-dependent NAD kinase 2.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.