PharMolix/UniProtQA huggingface dataset:
Protein: YAHM_ECOLI
Sequence: MAVQLFKTLLNQIPLLSSLQSGTLPLFGYSGWGRPMKKAHTGESGLKWEAKDSSKLIGNKDHALRGLSSPMAVIRQIRLIT
What are the official names of this protein?
Uncharacterized protein YahM.
Protein: GLT2_ORYSJ
Sequence: MSAAQGLALKLRAAPAAGGVRGEKRRRAASATAAAAARPRHGAMSLEGGFLGGALPAEDRVAPRASASRQAEAGAGAGAARPPPRSMSKIPESSIGLYDPSMERDSCGVGFIAELSGEYSRKTVDDAIEMLDRMAHRGACGCEKNTGDGAGILVALPHNFFREVTKDAGFELPPPGEYAVGMFFMPTDDKRREKSKLLFREKAELLGHTVLGWRRVPTDNSGLGQSAVDTEPVIEQVFVTKSASSKADFERQMYVLRRFSVMSIREVLGVKNGGTKDFYMCSLSSRTIVYKGQLKPSQLKGYFFADLGDESFTSYMALIHSRFSTNTFPSWDRAQPMRVLGHNGEINTLRGNKNWMKAREGLLKCEGLGLTRDEMLKLLPIVDATSSDSGAIDNVLELLIQSGRSAPEAVMMMIPEAWQNDVNMDPERKALYEFFSALMEPWDGPALISFTDGRYLGATLDRNGLRPGRFYVTYSGRVIMASEVGVVDVPPQDVSRKGRLNPGMMLLVDFENHCVVNDDELKKEYSKVRPYGEWLKRQRIQLTDIIESVNEAERIAPSISGALPITKENKADMGICGILTPLKAFGYTREALEMLMLPMAKDGQEALGSMGNDTPLAVMSNREKLTFEYFKQMFAQVTNPPIDPIREKIVTSMECMIGPEGDLSETTERQCHRLTLKSPLLNTNEMEAIKKMNYRGWRSKVLDITYPKKNGRMGLKQTLDKICAQAREAIHEGYTILVLSDRGFSSERVAVSSLLAVGAVHQHLVSHLERTRIGLLVESAEPREVHHFSTLIGFGADAICPYLAIEAIWRLQIDGRIPPNDGKPYTQEQLIEKYFYASNYGMMKVLAKMGISTLASYKGAQIFEALGLASEVVSKCFEGTPSRVEGATFEMLAQDALRLHEIAFPSRTLPPGSADANALPNPGDYHWRKNGEVHLNDPFSIAKLQEAARINSREAYKEYSRRIYELNKACTLRGMLKFREIPNQISLDEVEPAKEIVKRFCTGAMSYGSISLEAHTSLAEAMNTLGGKSNTGEGGEQPCRMVPLPDGSKNPRISAIKQVASGRFGVSIYYLTNAVEVQIKMAQGAKPGEGGELPGHKVIGDIAVTRNSTAGVGLISPPPHHDIYSIEDLAQLIHDLKNANPGARISVKLVSEAGVGIVASGVVKGHADHVLISGHDGGTGASRWTGIKNAGLPWELGLAETHQTLVANGLRGRAVLQTDGQMKTGRDVAVACLLGAEEFGFSTAPLITLGCIMMRKCHTNTCPAGIATQDPVLRAKFAGKPEHVINYFFMLAEEVREIMAQLGFRTVNEMVGRSDMLEIDPKVLEGNEKLENIDLSRLLKPAAEISPGAVQYCVEKQDHGLDMALDNKLIASSTAALRKGVRVFIETPVRNINRAVGTMLSHEVTKRYHIHGLPSDTIHIKLNGSAGQSFGAFLCPGITLELEGDSNDYVGKGLSGGKIVVYPPRNSRFNPQDNIVIGNVALYGATKGEAYFNGMAAERFCVRNSGAQAVVEGIGDHGCEYMTGGTAVILGKTGRNFAAGMSGGIAYVYDVDGKFSSRCNYELVDLYAVVEEDDITTLRMMIQQHRLHTQSDLARDILLNFDTLLPKFIKVYPRDYKRVLDKLKEEKAAKEAEQKAREVVDKKPVEVIQAPNGISVKTEKVMNEEPSSRPSRVSNAVKYRGFIKYEREGTSYRDPNERVKDWNEVAIELVPGPLLKTQSARCMDCGTPFCHQEGSGAGCPLGNKIPEFNELVHQNRWHEALDRLLETNNFPEFTGRVCPAPCEGSCVLGIIDNPVSIKSIECAIIDKGFEEGWMVPRPPLRRTGKRVAIVGSGPAGLAAADQLNKMGHFVTVFERADRIGGLMMYGVPNMKADKEGIVQRRVELMAKEGVQFIVNAHVGSDPLYSVEKLRSENDAIILACGATKPKDLPIPGRELAGIHFAMEFLHANTKSLLDSNLEDGNYISAQGRKVVVIGGGDTGTDCIGTSIRHGCTNLVNLELLPEPPRKRAPDNPWPQWPRIFRVDYGHQEATSKFGKDPRSYKVLTKRFIGDENGNVKALEVIRVEWGKVNGRFQFKEVEGSEEIIEADLVLLAMGFLGPEATVANKLGLEQDMRSNFKAQFGNFATNVEGVFAAGDCRRGQSLVVWAITEGRQAAAAVDNYLSKDDEGETNGTEDIAVSSEGLVQPVVA
What is the function of this protein?
Involved in glutamate biosynthesis.
What are the official names of this protein?
Glutamate synthase 2 [NADH], chloroplastic, NADH-dependent glutamate synthase 2, NADH-GOGAT 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KGUA_RHILO
Sequence: MVPRDLGSRIRRRGLMLVLSSPSGAGKSTIARNLLESDSSLELSVSVTTRPRRGSEIEGVHYHFRTMREFERLRDSDALLEWAEVHGNCYATPREPAELALAQGRDMLFDIDWQGAQQLKEKMRADIVSIFILPPSMKELKARLKRRAEDQEAVIETRLKNARNEIEHWKEYDFVIVNDDLDRAFAEVRGIVVAERLRRDRRPGLFDFVSGLLDEKTV
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACF_GANAU
Sequence: FQLNVIANNNNHTMLTQTTIHCHGFFQGTNSADGHAFVNCCPIASGHSFLYDFSHPDQHGTFCYHSHLSTQYCCGLRGHFVVYDPSDPHCGLYDVDHDSTVITLSDWYHVAAKLGHSFCLGADSTLINGSGRSTGDCAASLTVISVTQGKRYRFHLVSLSCDPNHTFSIDGHDMSVIEVDSIASQHVTVDSIQIFAGQRYSFVLTANQSINNYWIRANPSFGNIGFHDGINSAILRY
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products (By similarity).  Multicopper oxidase that catalyzes the oxidation of a variety of substrates, including phenolic and non-phenolic compounds (PubMed:34467865).  Has highest activity towards 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), also active towards hydroquinone, phenol, gallic acid, catechol, guaiacol, levodopa, 2,6-dimethoxyphenol (2,6-DMP), tyrosine, ferulic acid and veratryl alcohol (PubMed:34467865).
What are the official names of this protein?
Laccase, Galacc-F, Benzenediol:oxygen oxidoreductase S, Diphenol oxidase S, Urishiol oxidase S.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: MUTH_SHESW
Sequence: MKAIIPPENLTELLERANMMAGVSLAQIAANRGITVPKNLKRDKGWVGQLIEMELGATAGSKPEQDFLHLGVELKTIPINVQGKPLETTYVCVAPLSQIEGLTWENSLVCHKLQRVLWVPVEGERQISVGARRIGTPILWQPDPDELRLLQQDWEEIMELIALGKVEKLTARHGEVLQLRPKAANSRALTQSIAENGSLKMTNPRGFYLKTAFTAMILNKAFG
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_METRJ
Sequence: MSAETPINVVGGGAWGTALANAAAGAGHPVTLWLRDAGAAAALQAQRENPRYLPGVPLHPAIRATGEAVDLAGARATLLVVPAQTVRGVLESLRGPLATAGPVILCAKGIERGSDSFMSAVAEQVLPSGTPVAVLSGPSFAIDVARGLPTAVTLAAADAGRAAALSALLSGPSFRLYHTDDVRGVEIGGAGKNVLAIACGIVAGRGLGESARAALIARAFAELMRFARPFGGRPETLMGLSGLGDLVLTASSPQSRNFAFGQRLGAGASPAEAAGGKLAEGAFTAAALAGLAAAKGIEMPVAAAVAAIVAGTASVDDVIAGLLARPLRGETD
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTXL_MESMA
Sequence: MKFLYGIVFIALFLTVMFATQTDGCGPCFTTDANMARKCRECCGGIGKCFGPQCLCNRI
What is the function of this protein?
Toxin with unknown function in healthy organisms.  On glioma cells, inhibits chloride currents in a voltage-dependent manner (when tested on gliomas cells) (PubMed:17166663).  Also interacts with MMP2 and significantly inhibits its catalytic activity (PubMed:21424168).  May be internalized with chloride channels (probably ClC-3/CLCN3) and MMP2, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation.
What are the official names of this protein?
Chlorotoxin-like BmK CT, BmKCT, Bm-12, BmKCL1, BmKClTx3, BmKClTx4, CT neurotoxin, Short-chain toxin KCT, TXCL1.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNLJ_RUEST
Sequence: MDEADARAEFEALQTKIEKADHDYHQKDAPTLSDADYDRLKRRYLALADAFPILAKDGTRVASVGAPAASGFGKVTHAQRMMSLGNAFEDQDVEDFAVGLRRYLGLSSEAPLAFTAEPKIDGLSLSLRYEAGKLVQAATRGDGAVGENVTENARTISDIPQEISGAPEVLEVRGEVYMSHADFEALNARHAETGGKIFANPRNAAAGSLRQLDAEITRARPLRFFAYSWGELSEPLAETQIDAIERLASLGFQTNPLTRCCEQISELLAHYHAIEEQRADLGYDIDGVVYKVNDLSLQERLGFRSTTPRWAIAHKFPAELAWTHLEGIDIQVGRTGALSPVARLHPVTVGGVVVSNATLHNEDYIAGLDSKGAPIRGGKDIRVGDWVQIYRAGDVIPKVADVDLSRRPEGTERYAFPTRCPRCDSPAVREEGDAVRRCSGGLICPAQAVEKLKHFVSRAAFDIEGLGAKQVEQFHSDGWVKEPADIFELQQRYGSGLQQLKNREGWGEKSASALFAAIEDKRRIEFARLIFGLGIRHVGEVAAKDLALHFRTWSALAEAADLARAAALAHRAADEAEIVERQEAQASARRAKISEARNAAVATCAVAPDSQAAWDDLISVDGLGPTVALSLSDAFANPEERAAFDRLIAHLEIIEPDAPADDSPVAGKTVVFTGTLEKMTRAEAKARAEALGAKVSGSVSKKTDILVAGPGAGSKAAKAAELGIQTLDEDGWLDLIGQA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DNAJ_PSEE4
Sequence: MAKRDFYEVLGVERGASEGDLKKAYRRLAMKYHPDRNPGDKESEDKFKEANEAYEVLSDTSKRAAYDQYGHAGVDPSMGGGGAGFGGANFSDIFGDVFSDFFGGGRGGSRSGGAQRGSDLRYTLELNLEEAVRGTTVSIRVPTLVNCKPCDGSGAKKGSTPSTCPTCGGIGQVRMQQGFFAVQQTCPRCHGQGKIITDPCNSCHGEGRVEEYKTLSVKVPAGVDTGDRIRLSGEGEAGTHGGPTGDLYVVINVREHDIFQRDGKHLYCEVPISYTDAALGGELEVPTLDGRVKLKIPEGTQTGKQFRLRGKGVAPVRGGAAGDLLCRVAVETPVNLSRRQRELLEELRDSLEGDSSHSPKASGWFEGVKRFFGDL
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_GEOSM
Sequence: MTRLISADKSEDDLLEASLRPRALSDYVGQEKAKGNLGLFIDAARGRGEALDHVLLYGPPGLGKTTLANIIACEMGVNIKSTSGPVIERPGDLAAILTNLEAHDVLFIDEIHRLSHVVEEILYPAMEDFQLDIIIGQGPSARTIKLDLPKFTLVGATTRAGLLSSPLRDRFGVISRLEFYTHDELAFIITRSARIFGMAIAPEGAMELARRSRGTPRIANRLLRRVRDFAQVRADGVITRAVADQALALLEIDEMGFDMMDRAILLTIIDKFGGGPVGLDTIAAAISEESDTIEDVYEPFLIQNGFLNRTPRGRVATAAAYSHFGRIAPEPPQGKLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RNC_LEPIC
Sequence: MSFKKAQSHFFLKNPERVRSLQKLSKKIGIKFSKVEYYNTAFIHSSYKNENQEILEDNERLEFLGDSVLGLVAARSLFRKYPKANEGELSRIKSRIVSTPILNSISEKLELSEYLLLGKGEKNSLGKGRRKLSANLFESLVGAIYLDQGFEIAEKFILRHLSEFVENPEKEESVRDYKTQLQEYSQKHFKILPIYRTKSESGPDHAKTFQVVVRIRDQWEASGSGVSKKSAEQNAAKELYNRIRKKT
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPF2_CORGL
Sequence: MAPHQKSRINRINSTRSVPLRLATGGVLATLLIGGVTAAATKKDIIVDVNGEQMSLVTMSGTVEGVLAQAGVELGDQDIVSPSLDSSISDEDTVTVRTAKQVALVVEGQIQNVTTTAVSVEDLLQEVGGITGADAVDADLSETIPESGLKVSVTKPKIISINDGGKVTYVSLAAQNVQEALELRDIELGAQDRINVPLDQQLKNNAAIQIDRVDNTEITETVSFDAEPTYVDDPEAPAGDETVVEEGAPGTKEVTRTVTTVNGQEESSTVINEVEITAAKPATISRGTKTVAANSVWDQLAQCESGGNWAINTGNGFSGGLQFHPQTWLAYGGGAFSGDASGASREQQISIAEKVQAAQGWGAWPACTASLGIR
What is the function of this protein?
Factor that stimulates resuscitation of dormant cells.  Has peptidoglycan (PG) hydrolytic activity.  Active in the pM concentration range.  Has little to no effect on actively-growing cells.  PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity (By similarity).
What are the official names of this protein?
Resuscitation-promoting factor Rpf2.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase family. Rpf subfamily.
What are the subcellular locations of this protein?
Secreted. Cell surface.
Protein: PLSB_SODGM
Sequence: MSGWRRIYYTLLDLPLKLLVRSKVIPADPRAEAGLDPRQPMMYMLPYNSKADLLTLRMQCLKQGLPDPLTPLDIDGVTLPRYVFIHDGPRVLTWYAEKSQSVSLFHNYLDLHRSNPALDVQLVPVSVMFGRSPGRESQTSQPAPQLRLLNGIEKFFAVLWLGRDSFVRFSRPLSLRYMATEHGTDKSIAQKLARVARIHFARQRLVAAGPRLPVRQDLFNKLLASKAIEKAVEDEARSKKISVEKAQQNAIELMEEIAADFSYEAIRLSDRVLSWTWNRLYQGLHVRNAERVRQLAEEGHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTIFREYLGELFTRGYSVEYFVEGGRSRTGRLLEPKTGTLTMTIQAMLRGGNRPITLVPIYVGYEHVMEVATYAKELRGAAKEKEGLWQMMRGLRKLRNLGQGYVNFGDPLPLATWLSQQVPQWRDSIDPIEAQRPSWLAPAVDEIAATLMVRINNAAAANAINLCSSVLLASRQRSLTRPHLLAQLACYFELLRNVPYAPDITVPDLTPEALLAHALAMNKFTVEHDTIGDIICLSRDQAVLMTYYRNNIQHLLILPSLVASIICGHPGIERAQLQQRITLLYPLLKAELFMRYSKQELSPVIDSLIAELARQGLVDAQETRLYPAQTRLHVLQLLAASVRETLQRYAITFSLLRANPQLNRGTLEKESRIMAQRLSVLHGINAPEFFDKAVFSTLVATLRAEEYISDTGDAIDEKVSEMCDILSELITPDVLGTIESASLLAHGPASAALPAD
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYY_BRUA2
Sequence: MSGFKSDFLRTLSERGFIHQISDESGLDELLAKETVTAYIGFDPTAPSLHAGGLIQIMMLYWLQQTGHKPVALMGGGTGMVGDPSFKDEARKLMTEDTIAENMASIKRVFANYLTFGDGANDALMVNNGEWLRNINYLEFLRDVGRHFSVNRMLSFDSVKLRLDREQSLSFLEFNYMILQAYDFVELNKRYGLRLQMGGSDQWGNIVNGIDLGHRMGTPQLYALTSPLLTTASGQKMGKSLGGAIWLNADMLSAYDFWQYWRNTEDADVERFLKLYTTLPLDEIARLAELGGAEINEAKKILATEVTAMLHGRDAAEEAAETARKTFEDGELSENLPTVGVHKATLNDGIGVLALMVLAELCTTNGEARRHVEGGAVRINDEPVSDPRMVVNAAALNDQGLIKLSLGKKRHVLIRPA
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUDHA_PYRFU
Sequence: MPRLIKDRVPTPERSVGERVRDFGEVNLGYSWELALREAERCLQCPVEYAPCIKGCPVHINIPGFIKALRENRDNPSKAVREALRIIWRDNTLPAITGRVCPQEEQCEGACVVGKVGDPINIGKLERFVADYAREHGIDDELLLEEIKGIKRNGKKVAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGVLIYGIPEFRLPKEIVKKELENLRRLGVKIETNVLVGKTITFEELREEYDAIFIGTGAGTPRIYPWPGVNLNGIYSANEFLTRINLMKAYKFPEYDTPIKVGKRVAVIGGGNTAMDAARSALRLGAEVWILYRRTRKEMTAREEEIKHAEEEGVKFMFLVTPKRFIGDENGNLKAIELEKMKLGEPDESGRRRPIPTGETFIMEFDTAIIAIGQTPNKTFLETVPGLKVDEWGRIVVDENLMTSIPGVFAGGDAIRGEATVILAMGDGRKAAKAIHQYLSKEK
What is the function of this protein?
A bifunctional enzyme that catalyzes the reduction of elemental sulfur or polysulfide to hydrogen sulfide with NADPH as electron donor.  Also functions as a reduced ferredoxin:NADP oxidoreductase with a very high affinity for reduced ferredoxin.  Exhibits a broad specificity for various physiological and non-physiological substrates with varied reduction potentials such as methyl viologen, benzyl viologen, FAD, FMN, methylene blue, 2,6-dichlorophenolindophenol (DCIP), cytochrome C and ferricyanide with highest preference for benzyl viologen.  Does not reduce fumarate, succinate, nitrate, nitrite, sulfate, sulfite or protons.  Does not possess any hydrogenase activity or NADPH-dependent glutamate synthase activity.
What are the official names of this protein?
Sulfide dehydrogenase subunit alpha, SuDH, Ferredoxin:NADP oxidoreductase, FNOR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KKX21_OPIMA
Sequence: DPCYEVCLQQHGNVKECEEACKHPVEY
What is the function of this protein?
OmTx2 decreases the amplitude of the potassium current of the rat channels Kv1. 1/KCNA1 by 8% and Kv1. 2/KCNA2 by 10% as well as human Kv1. 3/KCNA3 by 36%.  Also alters glucose-induced insulin release from pancreatic islets.
What are the official names of this protein?
Potassium channel toxin kappa-KTx 2.2, Toxin OmTx2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 2 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SEB2_CAEEL
Sequence: MNPSISTAGAVVDDFQMSCRFSNFGDHAPESFDSLSCGACFYFIFMLVEHYKDRYVASLCEDTFGVLVCPVDVSDKICNCYNREYVYNIPEFALNSSRIKPLNHLRLDPPLPFQFDLIVKDCCSAARYCCRNTLVKYHHRVDDSPCPPTWDGWNCFDSATPGVVFKQCPNYIYGGSNIKTDYDRLSQKVCRSNGWATPEVNAAAREHTDYTGCMSNGDVEARILAGLLTYSASVIFLIPAVFLLTLLRPIRCQPMFILHRHLLISCLLYGAFYLITVSLFVVNDAPLSSQVFQNHLFCRLLFSIQLRYLRLTNFTWMLAEAVYLWRLLHTAQHSEGETLRSYKVICWGVPGVITVVYIFVRSLNDDVGMCWIENSTVAWIEWMIITPSLLAMGVNLLLLGLIVYILVKKLRCDPHLERIQYRKAVRGALMLIPVFGVQQLLTIYRFRNVCLIYRLLHKSFCRRMCSEILVITSGEAGSRS
What is the function of this protein?
Not known.  Putative receptor.
What are the official names of this protein?
G-protein coupled receptor seb-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UVRC_ANASK
Sequence: MDANLRRKLDELPAEPGCYLMKDRAGEVVYVGKASSLRSRVRSYFDPGRGDQRAFVALLDELLGDLEVIVTRSEKEAVLLENELIKKHRPRFNVRLRDDKDFIVLKLDERHPYPRLEVRRAREKRQPGARYFGPYSSASSIRETLRMVNRHFQLRTCSDHVFDHRKRPCILYQIHRCPAPCVYEVAAEEYRQSVEDAVEFLEGREGELVERLRGRMDGAAAGLRFEEAARLRDQLQAVERSLEKQRVLMADRGDRDVIGLYREGPDLVVQVLSMRAGKLQDAQAHPFREQEFPDEEILSSFLSLYYEHTDAPDEILVPLEPVQAEALADVLSERRGRRVRLLTPQRGAKADLLDVARRNAEQGFRAWHEHDERREQALAAVERALHLARPPRWMECYDISTFQGALAVGSGVSMKDGEPDKANYRRYKVKAVAGQDDFAMLHEVITRRLRRALGEGQLPDLIVIDGGKGQLNAALAAAKDLGVPTRPSPGNPDAPFVELVGLAKSRLVDGPSLGTARVVGRRGRRAEARLADAAEAAEKGFVSELARSPERVFLPGRKDPVVLRQNSAELFLLARLRDEAHRFAITFHRKLRRERNFQSVLEEIPGIGEGRKRALLRHFGALRRVREATPEELAQVEGFGPRQAAAVHAFFHRPDAPPIAADEPSGAPAAAPGGGPTDASPEAVAAATEAEIDAALADEDASPEPAA
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS2_STRP7
Sequence: MNKKILETLEFDKIKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLTSRELQSFYANLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHDSESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRVLKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFIDQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: PAK3_RAT
Sequence: MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHQSNTKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNKEATPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAIKNSSR
What is the function of this protein?
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation.  Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity.  Acts as downstream effector of the small GTPases CDC42 and RAC1.  Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.  Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.  Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments.  May also be involved in early neuronal development (PubMed:12890786).  In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PAK 3, Beta-PAK, p21-activated kinase 3, PAK-3, p65-PAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWEET_ECOU3
Sequence: MDTILLTGLFAAFFTTFAFAPQSIKTIRTRNTEGISVVMYIMFLTGVISWIAYGIMRSDFAVLIANIVTLFLAAPVLVITLINRRKKHV
What is the function of this protein?
The homodimer mediates transmembrane sugar transport down a concentration gradient.  Transport is probably effected by rocking-type movements, where a cargo-binding cavity opens first on one and then on the other side of the membrane.
What are the official names of this protein?
Sugar transporter SemiSWEET.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.