PharMolix/UniProtQA huggingface dataset:
Protein: RPAP2_MOUSE
Sequence: MADSAVPCSLGPSTRASSTHRDATGTKQTRALKRGDASKRQAELEAAIQRKVEFERKAVRIVEQLLEENITEEFLKECGMFITPAHYSDVVDERSIIKLCGYPLCQKKLGVIPKQKYRISTKTNKVYDITERKSFCSNFCYRASKFFETQIPKTPVWVREEERPPDFQLLKKGQSGSSGEVVQFFRDAVTAADVDGSGALEAQCDPASSSSWSERASDEEEQGFVSSLLPGNRPKAVDTRPQPHTKSSIMRKKAAQNVDSKEGEQTVSEVTEQLDNCRLDSQEKVATCKRPLKKESTQISSPGPLCDRFNTSAISEHKHGVSQVTLVGISKKSAEHFRSKFAKSNPGSGSASGLVHVRPEVAKANLLRVLSDTLTEWKTEETLKFLYGQNHDSVCLKPSSASEPDEELDEDDISCDPGSCGPALSQAQNTLDATLPFRGSDTAIKPLPSYESLKKETEMLNLRVREFYRGRCVLNEDTTKSQDSKESVLQRDPSFPLIDSSSQNQIRRRIVLEKLSKVLPGLLGPLQITMGDIYTELKNLIQTFRLSNRNIIHKPVEWTLIAVVLLLLLTPILGIQKHSPKNVVFTQFIATLLTELHLKFEDLEKLTMIFRTSC
What is the function of this protein?
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes.  Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).  Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:35975910).
What are the official names of this protein?
Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2, RNA polymerase II-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the RPAP2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.
Protein: OSGI1_MOUSE
Sequence: MTSWRHDSLGASSSEPLPVVIIGNGPSGICLSYLLSGHIPYVKPGAVHPHPLLQRKLAEAPGVSILDQDLEYLSEGLEGRSQSPVALLFDALLRPDTDFGGSIDSVLSWKRQKDRAVPHLVLGRNLPGGAWHSIEGSMVTLSQGQWMSLPDLQVKDWMRKKCRGLRNSRATAGDIAHYYRDYVIKKGLSHNFVSGAVVTAVEWAKSEHGSPEVQASSPLFQVNGYLTTKDHGHQPFSLRARNVVLATGTFDSPAMLGIPGETLPFVHHDLSALEAALRAGTVNPTSDPVLIVGAGLSAADAVLFARHYNIQVIHAFRRSVHDPGLVFNQLPKMLYPEYHKVQQMMRDQSILSPSPYEGYRSLPEHQPLLFKEDHQAVFQDPQGGQQLFGVSMVLVLIGSHPDLSYLPRAGADLVIDPDQPLSPKRNPIDVDPFTHESTHQEGLYALGPLAGDNFVRFVQGGALAAASSLLKKETRKPP
What is the function of this protein?
Regulates the differentiation and proliferation through the regulation of cell death.
What are the official names of this protein?
Oxidative stress-induced growth inhibitor 1.
What is the protein family that this protein belongs to?
Belongs to the OKL38 family.
Protein: SST_SCHPO
Sequence: MLRASSKRLQLSWQVFRRFQSSNPQLSFPCVDQAQERSRQFEQSLQKQQACPNSVDPSASITSPSLSSGPEPVYGKIVSGFKKFYHNKPFLCDHGGILPKFEIAYETWGTLNKDHSNAILLHTGLSASSHAHSHPENTAPGWWEQFIGPGKDVDTNKFFVICTNVLGSCYGSTGPSSVDPGDGKHYATRFPIITVNDMIRAQLLLLDHLKIEKLYASVGSSLGGMQSLTLGALAPHRVGRIASISGGARSHPYSIALRFTQRQILMNDPYWNRGFYYDGVPPHTGMKLAREVATISYRSGPEWEQRFGNRRADPSVSPAFCPDFLIETYLDHAGEKFCLQYDPNSLLYISKAMDMHDMSASHQRSLSENRKKNQHKLDKYLSADVSAEEIIKLNEDTSVLPDVPYQEIANEDRAPEPDPETNLIAGLAPLKDTPVMVMGVESDNLMPVECQRETARCLEKAGNKQVVYHELDANESFYGHDTFLIYRKDLDLVGGKLKKFLELS
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine.  Has also weak serine acetyl transferase activity and homoserine succinyl transferase activity.
What are the official names of this protein?
Serine O-succinyltransferase, SST.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RECR_COLP3
Sequence: MKFSPLVQELIDSLKCLPGVGAKSAQRMAFQLLERNRRGGSKLANTLAKAMTDIGHCQQCRNFTEEALCEICQSPKRQLSTTLCIVETPGDVIAIEQTGEFFGKYFVLMGHLSPIDGIGPDDLGLDILAKQFATGQFSEVILATNPTVEGEATAHFIAELAQQHQVNISRIAHGVPVGGELEYVDGNTLSHALSGRKSYQI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RL4_CUPPJ
Sequence: MELKLLQDNGQVGAGVAASPEVFGRDYNEALVHQIVVAYQANARSGNRKQKDREEVKHTTKKPWRQKGTGRARAGMSSSPLWRGGGRIFPNSPEENFSQKVNKKMFRAGMRSIYSQLAREGRINVVDGFTVDAPKTKLLADKFKAMGLDSVLIITDSLDENLYLASRNLPHVAVVEPRQADPLSLVHYKKVLVTKAAVAQIEELLK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ZO6_XENLA
Sequence: TRLDGFICSKCGETFTVNSHLLTHLCGKHERIYSREKLYSCTECRRTFTTDTELQSHQMIYMERDPFTCTECGKSFSERDNLKCHHKTHTGEKPFTCMECGKGFSVKSSLKHHYKAHITEKAVRCTECGKEFTSKYYLNVHKRLHTGEKPFTCTQCGKCFSDKSALKYHHKTHTGEKPFACTECGKSFTEKSILQKHQRTHTGEKPFTCTECGKSYSAMSTLECHRRTHTGEKPFTCTECGKSFTEKSILRKHHKTHTGEKPFTCTECGKSCTEKSILRKHQITHTGEKPFTCTECGKCFSDKTALKYHHKTHTGEKPFACTECGKSFTDKSILRNHQRTHTGEKPFTCTECGKSYSAMSTLKSDRRTHTGEKPFTCTECGKSFTEKSILRKHHKTHTGEKPFTCTECGKSFTHKSILQKHQRTHTGEKPFTCTECGKCFSDKTAIKYHRITH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Oocyte zinc finger protein XlCOF6.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYA_METM7
Sequence: MEINHDYRVKLFDELGFERKQCTECNQWFWTLDKDRTTCGDSPCDEYSFIGSPITRKKYTYNEMVREFTNFFAEKGHSPVKRSPVVAKRWRDDILLTIASIAVFQPWVTNGLVKPVKNPLVIAQPCIRLNDIDNVGRTGRHLTCFTMGAHHAFNSKDDYKYWTDKTVEYCFELMNRLGIDGKTITFIESWWEGGGNAGPCYEVITHGVELATLVFMQYKKVGSEYEEIPLKIVDTGYGIERFAWASQGTPTVYESLFSEVIEKLKEDAGIPGVDEKIMAESATLAGLMDIENVGDLRVLRQKVAEKIGMDVDELDKLISPLEYIYAIADHTRCLSFMFGDGIVPSNVKEGYLARLVLRKTLRYMEKIGISMSIKDIISMQLENMKEIYPELSEMKEYIMDVLDSEEKKYIQTVNRGRGIVERMAASKSEITLDDLIELYDSNGLPPEIVKDVVDELNKKGKKTIAITVPDNFYTIVAERHEEEKPEEVVSTKKELPEVEVSETELLFFKHPTQVEFEAKVLKTVEKYVVLDKTLFYAEGGGQKYDIGQINGIEVIDVQKKNGIVFHKVSDISKFKEGDIVKGTVNWENRLKLMRNHTATHVINAAATRVLGKHIWQTGSNVDTEKGRLDITHYERISREQVKEIERIANEIVLSKMPVNSTFMDRNDAEQKYGFTIYQGGVVPGDTLRIIEIEGTDVEACGGTHCSNTSEIGYIKVLKTERIQDGVERLEYSTGMGSVSEIAVLEDTLIDSAEILGIPNDQLPKTVKRFFEEWKEQKKTIEELQKKVGELVKYELADKFEKYGNYEVLVEQVSGTPNELMSIADNLAVGNKLIVLMNENDYLLCKRGENVELSMKELIRNIGKGGGKDNLAQGKYSENKEQITEKIIQILNK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_GRAFK
Sequence: MSGLIGKKIGMTSIFDENGKNIPCTVIQAGPCVVTQVRTKEVDGYEALQLGFDDKKTVGKAAEGHAKKAGTVAKRKVVEFQGYNEDYKLGDSVTVEHFKEGEFVDIAGTSKGKGFQGVVKRHGFGGVGQATHGQHNRLRAPGSIGAASYPARVFKGMKMAGRMGGERVKIENLRVLKVVADKNLLVIKGCVPGSKNSYVIISK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: CI130_HUMAN
Sequence: MAANATSGRPPSIALRQPEATGWRRGIPAKVATKGTQAEREGDVRSGGRARGRCVRLAKRCSPSSLGLRRRRRRTGGRQGDPQIFLGSDFRLLTPANSNPVLENPARTGSRIVIGISRERNLPFCGRSNLPDVSSL
What are the official names of this protein?
Putative uncharacterized protein ERCC6L2-AS1, ERCC6L2 antisense RNA 1, Nasopharyngeal carcinoma-associated gene 12 protein.
Protein: PELA_COLGL
Sequence: MRSASILSAALAAFAPLASAADAVSGAAEGFAKGVTGGGSATPVYPSTTAELASYLKDSSARVIVLTKTFDFTGTEGTTTETGCAPYGTAAACQVAINKDNWCTNYQPNAPKVSVSYDKAPFNPLIVGSNKSLIGQGSKGVIKGKGLRITNSAKNVIIQNIHITNLNPKYVWGGDAISLDGTDLVWFDHVKTSLIGRQHIVLGNGASNRVTISNNEIDGSTSWSATCDNHHYWGVYLTGSNDMVTFSKNYIHHTSGRSPKIAGNSLVHISGNYFYANSGHAMEADAGAKVVLEGNVFQNVVAAMQSGLAGKVFSSPDANTNAQCSSYLGHTCQLNAYGSSGSLSGSDTSILSSFSGKNVAATVTANDAKNVPNTAGFGKI
What are the official names of this protein?
Pectin lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: U2AF4_RAT
Sequence: MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIVLLNLYRNPQNTAQTADGSHCHVSDVEVQEHYDNFFEEVFTELQEKYGEIEEMNVCDNLGDHLVGNVYVKFRREEDAERAVAELNNRWFNGQAVHAELSPVTDFRESCCRQYEMGECTRGGFCNFMHLRPISRNLRRQLYGRGPRHRSPPRSHTGHRPRERNRRRSPDHRHGRF
What is the function of this protein?
RNA-binding protein that function as a pre-mRNA splicing factor.  Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection.  Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts.  Also participates in the regulation of alternative pre-mRNA splicing.  Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1.  Binds to RNA at the AG dinucleotide at the 3'-splice site.  Shows a preference for AGC or AGA.
What are the official names of this protein?
Splicing factor U2AF 26 kDa subunit, Liver regeneration-related protein LRRG157/LRRG158, U2 auxiliary factor 26, U2 small nuclear RNA auxiliary factor 1-like protein 4, U2AF1-like 4.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling.
Protein: KCY_RHOOB
Sequence: MSTSSLIVAMDGPSGTGKSSVSRMLARRLGARYLDTGAMYRIATLHVLRKGVDLADPDAIADATVGLPWSIGTDPAGEQVLLDGEDVGEEIRGDAVTKAVSAVSAVPAVRELLVAAQRRLACEAGRIVVEGRDIGTVVLPDADVKIYLTASAEARAQRRNAQNLAEGRGDDFAAVLADVQRRDHLDSTRAVSPLRPADDSVLVDTSELGIDDVIGRLLLVVSERSGVGQ
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMA_SALTM
Sequence: MKKNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKLRTDEYVQASRELFMPETNQAEVYYQLREEFNTCQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKRPYFPEAELYHFAEKAQNAFFYCESYADSMARADKSSVVYCDPPYAPLSATANFTAYHTNSFSLTQQAHLAEIAENLVSNRIPVLISNHDTALTREWYQLAKLHVVKVRPSISSNGGTRKKVDELLALYQPGVATPARK
What is the function of this protein?
An alpha subtype methylase, recognizes the double-stranded sequence 5'-GATC-3' and methylates A-2 (Probable) (PubMed:12654995).  May be involved in methyl-directed DNA mismatch repair, initiation of chromosome replication and gene expression (By similarity).
What are the official names of this protein?
DNA adenine methylase, DNA adenine methyltransferase, Deoxyadenosyl-methyltransferase, M.StyDam.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: NB_KOCRD
Sequence: MPIEIPTDLTPELVPFAWLLGTWEGNGFMGYGDAEQRAFRQRVTFEQTGLPFVIYRAQTTLLDEEGEPQREATYEQGFWELARPREDGDIGPGMLPPDPVPVLTSAEDVEKLRNADGGFDISVSILQPGGVAELYLGQIKGPRVDLRTDAVIRAQGAKEYQSGTRLYGLVNNHLMWAWDMAADGRELATHASAELTRIEPAAPSGS
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: COX2_BREAN
Sequence: MMLNNMLNDVPTPWGMFFQDSATPNMEGMMELHNNVMFYLCMMLGFVSYMLYNMLHNNKSVLPYKYLYHGQFMEMVWTTIPAMMLLMMAFPSFILLYMCDEVMAPAMTIKAMGLQWYWKYEYSDFMDDKGETMEFESYMIPEDLLEEGQLRQLDVDSPMVCPVDTHMRFMVTAADVMHDFAMPSLGIKIDAVPGRLNQTSALIQREGVYYGQCSELCGVMHSSMPMKIEAVSLGEFLAWIDEQ
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PGDA1_BACCR
Sequence: MYYFYSPEMFAPYQWGLERDVSYAYMPYNSFYYGDYINSLPYAYIPQNYEVQMKADDRGSWTPFSWVEKYAYAFSGPYNKAEVALTFDDGPDLEFTPKILDKLKQHNVKATFFLLGENAEKFPNIVKRIANEGHVIGNHTYSHPNLAKVNEDEYRNQIIKTEEILNRLAGYAPKFIRPPYGEILENQLKWATEQNFMIVQWSVDTVDWKGVSADTITNNVLGNSFPGSVILQHSTPGGHLQGSVDALDKIIPQLKTKGARFVTLPSMFQTSKERK
What is the function of this protein?
Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan (PubMed:15961396, PubMed:29983281).  Also acts on soluble chitin substrates and N-acetylchitooligomers.  Acts on cell wall peptidoglycan from the Gram-positive bacteria B. cereus and B. subtilis and the Gram-negative bacterium H. pylori.  Not active on acetylated xylan (PubMed:15961396).
What are the official names of this protein?
Peptidoglycan-N-acetylglucosamine deacetylase BC_1960, Peptidoglycan GlcNAc deacetylase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
Protein: TBB5_ECTVR
Sequence: MREIVHVQAGQCGNQIGSKFWEVISDEHGIDPTGSYHGDSDLQLERINCYFNEATGGRYVPRAILMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDALQGFQLTHSMGGGTGAGMGTLLISKVREEYPDRVMSTYSVIPSPKVSDTVVEPYNATLSVHQLVENADQCFTLDNEALYDICFRTLKLTTPTYGDLNHLVSAAICGTTCSLRFPGQLNCDLRKLAVNMVPFPRLHFFMIGFAPLTSRGSQQYRALTVPELTQQCFDSKNMMCAADPRHGRYLTCAVMFRGRMSTKEVDEQMLNVVNKNSSYFVEWIPNNVKASICDIPPKGLKMSTTFVGNTTAIQEVWKRVAEQFTSMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFDEDEELDDAMG
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-5 chain, Beta-5-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ENOA_MESAU
Sequence: AAVPSGASTGIYEALELRAVEHINKTIAPALVSKLAMQEFMILPVGASSFRIGAEVYHNLKDATNVGDEGGFAPNILENKEALELLKAGYTDQVVIGMDVAASEFYRFTASAGIQVVGDDLTVTNPKRAASEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERYNQILRIEEELGSKSFRNPLAK
What is the function of this protein?
Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate.  In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses.  May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons.  Stimulates immunoglobulin production.
What are the official names of this protein?
Alpha-enolase, 2-phospho-D-glycerate hydro-lyase, Enolase 1, Non-neural enolase, NNE.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M-band.
Protein: RL7_ACTSZ
Sequence: MSLTNEQLIEAIASKSVSEIVELIAAMEEKFGVSAAVAAAAPAAGGAAAAEEKTEFNVVLTEAGANKVAVIKAVRGATGLGLKEAKDLVESAPANLKEGISKGEAEELKKALEEAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: POL1_CNSV
Sequence: MGWICPNVSCLGHTSVLSNKEISREGRCERAMCGSLLVKVAVPQQPAKKKKQATPAPRPTYPPCVVEKTAATPVTVEKVFVEVIPTVPSCLAPKWMLGIQRVEGAPSKAPKQAVPKWVWQMRQLLKAALTGANSFGPRYVRAHFSRARISWIYAQLCEGCPLPLWNRGRALKKSSLALLARIEDTKQQKRAAWEKKEAAPLKSKREYEQKRALLIPLIEKLRARLLQDEARELREQLFPSGNGGTDTTKVAAASKAEIKAAAQLKAYQDVCAKVWRVKRQEKKAQQAKLVEDLITSANCGKQDVSEPAIEKAARPKRRIEIGDFVPQKTLWGLYPCVGLGANMADPVCRVLSACVSIAGKRPDLVSTIYAFITGEAQVWLSAPRVCMLAKRIIELSDWYPHELLAEELKKISDEENCKEAEREINLKYLEISKATENMRANGLFNKLKGKAQDLWSGIVDFASHPFRKYLATAAEFVEGFSHRVVDAVMSRVNAAIAQFAAQLDIAKTLVDQLVIHVKRWYTSLCTSFDDSLKLLGKWAGYALGLIVGVGVCHLVEVICAHMGLPLGGVITGVFTTAYMGWLFVKTPVGSELVMNLRMQVARIARNIFDVQRTGIPPDLPANPNVGFSVPYEAFGGIDNQPFSMGADVPNARAIPVVSPIINAMAGFGASMLSMKAMGLIEMGKLGAACHSLRMGKDALCEFVSTVLYYFGRLADKVTGRETEFFDELSILVQIDVKDWITRSRGVLLDSCYTSLNNMICSDVVNKLVTDGEQIASNIAGTPRRLSLDFGQLVSSIMKDLLDLQQRIVRHGVTVGRRKEPTWIYIFGPSHCGKSNMMDHLTSEVCRYFDLPYTYIARNGQDNFFTTGYKRQTVLQIDDLSCVENVPPIERELINLVSCSEYPLKMADLSDKSISFQSPFIISTSNQRTCLPTCGITHCEAFNNRRAVVVEMRRKPGVVFDPMDCHAAMQGRFLDKRDHTPLFGVQGQPETFWKDVPEMTTILLNICVAHRQEQDILQEQHIRKHAVNDPLILASERFLKQESRKALCYMPRVEMEICGVQSQAAGCYYLCVDQKLYTCEDDGNLVETPCLNPSYAQWERNSSENFVGGVQALDALECRSILVSGILRNLVQGQCCVLSIDEMSRLPLCTQRLFKALQLQERVYLRLIQKKISHILSVDESNVYSKNAWMRCLEFAAASRDYLKEHGLEVLLLLAAMMILCVALYYFVGAFIGVMGGALSMGAAMAGLKEVDMKAQYSSGAQEGRYRSRNIPIRQRYRYARGELDEEVPLGGQLAVALYGSQGRFISALQYKGKSVMLTRHQMLMFAEKERVTCIYLATGESVVLTFNRDDVQEFPNHETCMWQAAGMLQLPAKFKDCFLEKGETELAPAFELEGYVLRPDSTAFIMTILKTWARVQYEPFVVRGSLAKEKYVNELPTSIWFQYQSRNNDCGMVCLAQVGGKKKIVGLLVAGVDQQTWADNLPNPCMAEMKSQIEYEFKLGAHTEGYTKLGYLTKDKTPHLPKKNNAVLVKPEYRIDSPVPIKEPSIISAEDPRCPKDAEGKPIDPIVKAFEKKFTTPMDLLEDDILESIAQEMVDEWQDCESEPLCDVPLEVAINGIPGTQIDDDDEFEDAVECLKMRTSPGYPYVLHKEPGMKGKEAYFELAPDGTRALKEGSLAAELYENIVQYSKSAIPELVVIECPKDELLKTEKVNKACRPFEIMPLHYNLFLREKTLAFSLFQQRNRHKLACQVGTKAYSHDWTHMYQRLVAKSDRAINCDYSSFDGLLNSQVVSCIANMINSMYHSPEETVVSKRQRYNMINALFGRLAITGQEVMRVRAGLPSGFALTVVINSVFNEILMRYCFKVLVLGPQRNSFSTYVTLLVYGDDNLMSCTDKIAIYFNGETIKETLKKKNVTITDGSDKTAPDIKWKTLGELDFLKRRFLKLETGVVQAPLDLTAIFSCLHWVTPHPQKMPKGGAQLQVENVDTLYELALNVQVALTELYLHGNKEEFQRVRNFYTKKMNILPAGYYTWADREAFHMSKQTGMEAYQPAKEIDLDVGQEFARFMHTSDIGNQVHFTRQCLVVAGPFYKPTPDQLLVSTTPLKQGESGYWVPVETGMGIGNLPTIAWVHRFMRPTQLVDAYGYKIWGNVRSHIESGKSLVFRSEAPYVAGNAALMAFGQAAKLLEIKTALNLYRNVIPESTYGLEQYFDAAIPQASLPGTFYLANAESESLLQEHKTGTVIGLTTEKFNLNGARDLIMQGQKLGKLPVMAATQAPNKFYVGLCCQKNFCPGHATSSDSIAKAFSQCWAMRCAPNSSSRKVTFEPEWRKNKFLGIS
What is the function of this protein?
Picornain 3C-like protease is a thiol protease that cleaves the P1 and P2 polyproteins.
What are the official names of this protein?
RNA1 polyprotein, P1.
What is the protein family that this protein belongs to?
Belongs to the nepoviruses RNA1 polyprotein family.
What are the subcellular locations of this protein?
[Viral genome-linked protein]: Host endoplasmic reticulum lumen. SUBCELLULAR LOCATION: [Putative ATP-dependent helicase]: Host endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: T4G1E_AGEAP
Sequence: ACVGENKQCADWAGPHCCDGYYCTCRYFPKCICRNNN
What is the function of this protein?
Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects.  Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve.  This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.
What are the official names of this protein?
Mu-agatoxin-Aa1e, Mu-AGTX-Aa1e, Mu-agatoxin V, Mu-Aga V, Mu-agatoxin-5.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 07 (Beta/delta-agtx) family. 03 (aga-4) subfamily. Aga sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YE075_YEAST
Sequence: MGSSFVIDRSSSSPAPPRGPAPKLSAHARKIICKISPNRSFLFIISLHICEKYFISMGLRGHRSRFSRSVSTFFSPGKLACIAHLRVGCQIVPIFPYGAFLKTPYNRCAGNKVSESTHRRAVVRPSTRYFVTTFQDTETQLIIVSSVEVKKRKGIVILSIEFQSMHLKQRVDHHVVCLKGLVRPGNLVRLQQTSGTFLHFSRP
What are the official names of this protein?
Putative uncharacterized protein YEL075W-A.
Protein: NFIP2_HUMAN
Sequence: MARRRSQRVCASGPSMLNSARGAPELLRGTATNAEVSAAAAGATGSEELPPGDRGCRNGGGRGPAATTSSTGVAVGAEHGEDSLSRKPDPEPGRMDHHQPGTGRYQVLLNEEDNSESSAIEQPPTSNPAPQIVQAASSAPALETDSSPPPYSSITVEVPTTSDTEVYGEFYPVPPPYSVATSLPTYDEAEKAKAAAMAAAAAETSQRIQEEECPPRDDFSDADQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL
What is the function of this protein?
Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets.  As a result, may control many cellular processes.  Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes.  Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003).  May modulate EGFR signaling.  Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity).
What are the official names of this protein?
NEDD4 family-interacting protein 2, NEDD4 WW domain-binding protein 5A, Putative MAPK-activating protein PM04/PM05/PM06/PM07, Putative NF-kappa-B-activating protein 413.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane.
Protein: EFPL_PSET1
Sequence: MPKASEVKKGTAIDFNGRVLVVKDIVRSVPQGRAGGSLYRMRLYDVVTGSKVDETFKDSDMLTLADLTRREAMLSYIDGDEYVFMDNEDYTPYNLSKDAISEEILFVNEETQGVHVIVIDGAPVGLDLPSSVELVVEETDPSIKGASASARSKPARMSTGLNISVPEHISTGDRIRINTAEHKFMGRAEK
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: CBIN_SALG2
Sequence: MKKTLMLLAMVVALVILPFFINHGGEYGGSDGEAESQIQAIEPQYKPWFQPLYEPASGEIESLLFTLQGSLGAAVIFYILGYCKGKQRRDDRA
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
What are the official names of this protein?
Cobalt transport protein CbiN, Energy-coupling factor transporter probable substrate-capture protein CbiN, ECF transporter S component CbiN.
What is the protein family that this protein belongs to?
Belongs to the CbiN family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.