PharMolix/UniProtQA huggingface dataset:
Protein: AP2S1_PONAB
Sequence: MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE
What is the function of this protein?
Component of the adaptor protein complex 2 (AP-2).  Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways.  Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation.  AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.  The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components.  Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation.  AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis.  AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface.  AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.  AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway.  The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.  May also play a role in extracellular calcium homeostasis (By similarity).
What are the official names of this protein?
AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, Adaptor-related protein complex 2 subunit sigma, Clathrin assembly protein 2 sigma small chain, Clathrin coat assembly protein AP17, Clathrin coat-associated protein AP17, Plasma membrane adaptor AP-2 17 kDa protein, Sigma-adaptin 3b, Sigma2-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
Protein: RL10_COPPD
Sequence: MTRVRPEKQAVVEQLREWIDQSKGMVFFSFEGLTSKDMQAMRADMKRNGLTVKVVKNTLLELAVKEVGLNVDESLFRGTTALLFSNEDELAPFKLFVEQVKKYGVLQAKGGILEGRWISAKEVDAIAKLPGRQELYAQLVGVVSSPMRGLVTVLSGPYRNLVYVLQAIKEKKEKAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: TIM16_DEBHA
Sequence: MAHRLLVNVIFTGASVFGRAFTEAYKQAAKATASTPQGGAAKSTSVGGIPTDEALKILDLKKTDLSVAKIDEKYAYLFDVNSKDKGNSFYLQSKVYYAMDSLRKELDYLDKLKKTKDGSQGEAGPTST
What is the function of this protein?
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14.  May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM16, Presequence translocated-associated motor subunit PAM16.
What is the protein family that this protein belongs to?
Belongs to the TIM16/PAM16 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.
Protein: MURE_HELPJ
Sequence: MKLKKTLTYQHHAYSFLSDNTNEVLENPKEILFVKTPLNEKYAPLIAEKNLAILDFNELKNYFDFKIKIVGITGTNGKTTTASLMYSLLLDLNKKTALLGTRGFFIDDKHIKEKGLTTPTLLELYSDLEEAIRLKCEYFIMEVSSHAIVQKRIAGLDFALKILTNITSDHLDFHQNIENYRDAKNSFFKDEGLKVINRDETNALFNPINARTYALDKKAHLNVQAFSLNPSISASLCYQHDLRDPNLKETALIHSPLLGRYNLYNILAGVLGVKLLTQLPLETIAPLLENFYGVKGRLEIVHSKPLVVVDFAHTTDGMQQVFESFKNQKITALFGAGGDRDKTKRPKMGAIASCYAHQIILTSDNPRSENEEDIIKDILKGINNSSKVIVEKDRKKAILNALENLKDDEVLLILGKGDENIQIFKDKTIFFSDQEVVKDYYLNLKQG
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLSA_SALA4
Sequence: MTTFYTVVSWLVILGYWVLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAQENSSVASSLFKLCERRQGIAGVKGNQLQLLTDSDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSMNMVDPRFFKQDAGVGQWVDLMARMEGPVATAMGIVYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTATYAAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSLLVGWASRAFFSELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLVIDDTGFGADLAAVQDDYISRSRLLDARLWVKRPLWQRITERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL362_NEIMA
Sequence: MQVLSSLKTAKQRHRDCQIVRRRGKVYVICKSNPRFKARQR
What are the official names of this protein?
50S ribosomal protein L36 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RPI3_ARATH
Sequence: MASLSFVSSSHLTLRTPSIALRSTGSSPRTSVSFSVKAQSVALSQDDLKKLAAEKAVEAIKPGMVLGLGTGSTAAFAVDQIGKLLSSGELYDIVGIPTSKRTEEQARSLGIPLVGLDTHPRIDLAIDGADEVDPNLDLVKGRGGALLREKMVEAVADKFIVVADDTKLVTGLGGSGLAMPVEVVQFCWNFNLIRLQDLFKEFGCESKLRVDGDGKPYVTDNSNYIIDLYFKTPLKDGFAAAKEIGKFQGVVEHGLFLGMATSVIIAGKNGVEVMTK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Probable ribose-5-phosphate isomerase 3, chloroplastic, Phosphoriboisomerase 3, Protein EMBRYO DEFECTIVE 3119.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MAEL_DROVI
Sequence: MPPKKHTGFMMFVQEWRRNDAEGRKMSMPQAVSKCGELWKKMDAQQRGPYNGAAKEADVVMRCKVERMNCHGQALSAVQREEREAADRQMDMKRKIERMVLNGKAQHDLENTKFIFAAFNYFTKAITNDIYIPAEFAACEFSLKSGKSSLYSSHINPGQLIFGQGSDTLHHTSNTHQLPLPPNALGEANIGKLYVSIVEYLRGCQDGAGQPNEPLVVFTSTELVPVVRGCFRYLESDSDELQENIEVYDIQYLFYVLKKEVMDIADLPNEHINKSITDNLFVNDFFEYHSGISCQFHEDNDRGKYCTQSKVARWCYMFSDYMCGDLAIKPLPGKHMPPKQEPKFRVINPEEPIENRCFSGMTTTEKSSGNTSFASISSLQTEVKHEIVDHSAFSANLNASEDFPSLGGRKGKRNAEPLAKGVWNVPASNCSVKDLGDAFNMPRR
What is the function of this protein?
Involved both in the piRNA and miRNA metabolic processes.  As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons.  As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam).  Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
What are the official names of this protein?
Protein maelstrom.
What is the protein family that this protein belongs to?
Belongs to the maelstrom family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Protein: RL3_MARN8
Sequence: MAIGVVGRKAGMTRIFTDEGQALPVTVIEVEPNRITQLKTLESDGYRAVQVTVGSRRSSRVNKAAAGHFAKAGVEAGRGVWEFRLADGEGEDLAAGGELTVSVFEDGQVVDAVGQSKGKGFQGGVKRWNFSMQDATHGNSLSHRAPGSIGQNQTPGKVFKGKKMAGQMGNAQVTVQNLKIVRVDAERNLLLVSGAVPGATGGDVVIKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: GMAN2_ARATH
Sequence: MPFSSYIGNSRRSSTGGGTGGWGQSLLPTALSKSKLAINRKPRKRTLVVNFIFANFFVIALTVSLLFFLLTLFHFGVPGPISSRFLTSRSNRIVKPRKNINRRPLNDSNSGAVVDITTKDLYDRIEFLDTDGGPWKQGWRVTYKDDEWEKEKLKIFVVPHSHNDPGWKLTVEEYYQRQSRHILDTIVETLSKDSRRKFIWEEMSYLERWWRDASPNKQEALTKLVKDGQLEIVGGGWVMNDEANSHYFAIIEQIAEGNMWLNDTIGVIPKNSWAIDPFGYSSTMAYLLRRMGFENMLIQRTHYELKKDLAQHKNLEYIWRQSWDAMETTDIFVHMMPFYSYDIPHTCGPEPAICCQFDFARMRGFKYELCPWGKHPVETTLENVQERALKLLDQYRKKSTLYRTNTLLIPLGDDFRYISIDEAEAQFRNYQMLFDHINSNPSLNAEAKFGTLEDYFRTVREEADRVNYSRPGEVGSGQVVGFPSLSGDFFTYADRQQDYWSGYYVSRPFFKAVDRVLEHTLRGAEIMMSFLLGYCHRIQCEKFPTSFTYKLTAARRNLALFQHHDGVTGTAKDYVVQDYGTRMHTSLQDLQIFMSKAIEVLLGIRHEKEKSDQSPSFFEAEQMRSKYDARPVHKPIAAREGNSHTVILFNPSEQTREEVVTVVVNRAEISVLDSNWTCVPSQISPEVQHDDTKLFTGRHRLYWKASIPALGLRTYFIANGNVECEKATPSKLKYASEFDPFPCPPPYSCSKLDNDVTEIRNEHQTLVFDVKNGSLRKIVHRNGSETVVGEEIGMYSSPESGAYLFKPDGEAQPIVQPDGHVVTSEGLLVQEVFSYPKTKWEKSPLSQKTRLYTGGNTLQDQVVEIEYHVELLGNDFDDRELIVRYKTDVDNKKVFYSDLNGFQMSRRETYDKIPLQGNYYPMPSLAFIQGSNGQRFSVHSRQSLGVASLKEGWLEIMLDRRLVRDDGRGLGQGVMDNRAMTVVFHLLAESNISQADPASNTNPRNPSLLSHLIGAHLNYPINTFIAKKPQDISVRVPQYGSFAPLAKPLPCDLHIVNFKVPRPSKYSQQLEEDKPRFALILNRRAWDSAYCHKGRQVNCTSMANEPVNFSDMFKDLAASKVKPTSLNLLQEDMEILGYDDQELPRDSSQPREGRVSISPMEIRAYKLELRPHK
What is the function of this protein?
Catalyzes the first committed step in the biosynthesis of complex N-glycans.  It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.  Converts GlcNAcMan(5)GlcNAc(2) (Man5Gn) into GlcNAcMan(3)GlcNAc(2) (MGn) by sequential removal of two alpha1,6- and alpha1,3-linked mannose residues from the alpha1,6-mannose branch of the substrate.  To a lesser extent, also able to cleave beta1,2-xylosylated Man5Gn-glycopeptide (Man5GnX-GP) and pyridylaminated substrates Man5Gn-PA and Man5GnX-PA, but not active toward Man5-glycopeptide (PubMed:16460512, PubMed:21478158).  Required for resistance to salt stress (PubMed:18408158).
What are the official names of this protein?
Alpha-mannosidase 2, Golgi alpha-mannosidase II, AMan II, AtGMII, Man II, Protein hybrid glycosylation 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 38 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: LBN_BOVIN
Sequence: MKFSKEIEVFNPPLASSASSGPWVHSVFAFTHSWPRKTLFKRDSAVTHRLYGDISRDFQGTSENGVIFQKCAVVSVQSEWPSAHVRLFVNNTRTPTAANLSDLFLLDNITGLTIRESAGNQTSRGFQAFRKKFLQVGDSFSVSYTASLEARDVGSGDILLLPAQLSFQSSSPNRTQLKAPFTITAEEKITVLPNHGLHAAGFCVAFILSLVLTWAVLFFMVRYQCVKGSSLTRHQVQHHENKLEHSQFTSADGVNEDLALNDQMIDILSSEDPGSMLQALEELEIATLNRADSDLEACRTQISKDIIALLLKNLTSSGQLSPQVERRMGAVFKKQFLLLEKEIQEEYDRKMVALTAECDLETRKKTESQYQREMAAMEEAEEVLKRVSERSAVECSSLLRTLHGLEQEHLRRSLALQQEEDLAKAHRQLAIFQRNELHNIFFTQIKSAIFKGELKPEAAKMLLQDYSKIQESVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRMQGLLSTASAQLTLLIQKHERAGYLDEDQMQVLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLIIKRRREMLQKHKEQRREQLSIAEASGAAEDAGQYLGQWRGLMAEHSAALEELQERLDQAALDELRALTLSLSEKATEELRRLQNSGMTQELLKRGVPWLFLQQILEEHSRDLAARAERLEGEERDRGQEGVQSVRQRLKDDALEASTEEQAELRHWEHLIFTKLCSSAFSLSEEELLGMRQEVHGCFAQMDRSLALPKIRARVLLQRFQTAWREAEFLKLDQAMTAPELQPQSKARKPRSKSRSKIDLLKKCTEDKIQLFKEQAPEDLVEKVRGELLRERVQQLEAQEGLFAESLVSLQFQKAARMARTLWAYTALLSIQDLLLEELNSSETLTKSACMQILESHSPELQELERKLEDQLAHQEAAQLQRALDSWQQWAGEGPALLQEPEETDSERHVSAVLQRALSKGQKLLEYHQQSLREEQEDSVVLEDLLENMETDTFVTLYGQELRLASYLSKLTMLPGGTLRRLLTVALPAASQAELLAVLDSVGQKHQDHSVENDGSRVQADLGRRGKHQGWWQALESKLRGELINRGLEKMLWAQKRKESILKKTCPPLRERVIFSGKRSWPHLSLESTDELTPVPIVGAEAVDLLNTGEKLFIFRNPKEPEISLHVPPRKKKKNFLNAKKAAWALGLN
What is the function of this protein?
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling.  Plays a critical role in bone formation and skeletal development.  May be involved in early embryonic morphogenesis.
What are the official names of this protein?
Limbin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cell projection, cilium membrane. Nucleus. Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner.
Protein: FLIE_PSEPG
Sequence: MSQGVEFNRLMLDMRAMQADAMSLPKVTAAPELAPGQSTFADMLGQAIGKVHETQQASTQLANAFEIGKSGVDLTDVMIASQKASVSMQAMTQVRNKLVQAYQDIMQMPV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: T151B_HUMAN
Sequence: MSPPGSAAGESAAGGGGGGGGPGVSEELTAAAAAAAADEGPAREEQRPIQPSFTKSLCRESHWKCLLLSLLMYGCLGAVAWCHVTTVTRLTFSSAYQGNSLMYHDSPCSNGYVYIPLAFLLMLYAVYLVECWHCQARHELQHRVDVSSVRERVGRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHVAEAEFDYARCGVRDVSKTLVGLEGAPATRLRFTKCFSFASVEAENAYLCQRARFFAENEGLDDYMEAREGMHLKNVDFREFMVAFPDPARPPWYACSSAFWAAALLTLSWPLRVLAEYRTAYAHYHVEKLFGLEGPGSASSAGGGLSPSDELLPPLTHRLPRVNTVDSTELEWHIRSNQQLVPSYSEAVLMDLAGLGTRCGGAGGGYAPSCRYGGVGGPGAAGVAPYRRSCEHCQRAVSSSSIFSRSALSICASPRAGPGPGGGAGCGGSRFSLGRLYGSRRSCLWRSRSGSVNEASCPTEQTRLSSQASMGDDEDDDEEEAGPPPPYHDALYFPVLIVHRQEGCLGHSHRPLHRHGSCVETSL
What are the official names of this protein?
Transmembrane protein 151B, Transmembrane protein 193.
What is the protein family that this protein belongs to?
Belongs to the TMEM151 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RAG2_ONCMY
Sequence: MSLQPLTAVNCGSLLQPGCSLLQLDGDIFLFGQKGWPRRSCPTGVFGVRLKHGELKLRPISSSNDSCYLPPLRCPALTRLEPHDGHPEGYLIHGGRTPNNEISSSLYLLTLDSRGCNRKVTLRCQERELVGEQPGPRYGHTLSMVQSLGKRACVVFGGRSYMPAGERTTENWNSVVDCPPQVFIIDLEFGCCSAHTLPELTDGQSFHLALARDDYVYFLGGQSLSLDFRPPRVYSLRDGVPEGKPAVSCSTWTPSMSISSAIATRVGPSHEFIILGGYQLETQKRMECSSVVLDDSGINIEPREAPEWTGEIKHNHTWFGGSMGGGSALIGIPSEGRQATPEAHYFYQVCFQKEGEGKGEDGNQVCSQESTDFEDSAPLEDSEELYFGREPHELEDSSEGEGDTYNEEDEEDESQTGYWVKCCLGCQVDPNTWEPYYSTELLRPAMIYCSKGEGGHWVHAQCMELTEGLLVRLSQGNGKYFCLDHGGLPRQEMTPPRQVLSLKRSPMKPQHRKGPMMRRMTPAKKRFFRRLFE
What is the function of this protein?
Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination.  V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments.  DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.  In the RAG complex, rag2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1.  It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity).
What are the official names of this protein?
V(D)J recombination-activating protein 2, RAG-2.
What is the protein family that this protein belongs to?
Belongs to the RAG2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS6_TRIEI
Sequence: MNKFIYETMYILRPDMTEEKVEQAITKYKSMLEEQGAYDIKIQHRGKLRLAYEINNQREGIYIQMNYQGPPTQIAILERAMRLSEEVIRYLTVKQELPKTPETDTQKNLEPAVALAE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: URE3_RHOPA
Sequence: MNLSPREKDKLLVSMAAMVARRRLERGVKLNHPEAVALITDFIVEGARDGRSVAELMHAGAQVITRDQCMDGIAEMIHDIQVEATFPDGTKLVTVHQPIR
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM38A_DANRE
Sequence: MEVLDVLNLGEIAQYFSKMAMFPVFDVAYYIVSILYLKYEPGAVEVSRRSPVASWLCAMLYCFGSYILADIMLGVCPIDYFHNNSHILLASAVWYLIFFCPLNLFYKCVAFMPVKLVLVALKEVVRTRKIAAGVHHAHHAYHHGWLIMVITGYVKGSGVALMSNFEQLLRGVWKPETNEVLNMSFPTKASLYGAILFTLQEAHVLPVSKSTLICLFTLFMVSSKVFMTARHSHGSPFALIESWVCHVLFGSPLGTEDAHDHHHAAPAAAPAPLSPAKNKEELSEGTRKRKSKKAE
What is the function of this protein?
Monovalent cation channel required for maintenance of rapid intracellular calcium release.  May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
What are the official names of this protein?
Trimeric intracellular cation channel type A, TRIC-A, TRICA, Transmembrane protein 38A.
What is the protein family that this protein belongs to?
Belongs to the TMEM38 family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane.
Protein: RL123_ARATH
Sequence: MPPKLDPSQIVDVYVRVTGGEVGAASSLAPKIGPLGLAPKKIGEDIAKETAKEWKGLRVTVKLTVQNRQAKVTVVPSAAALVIKALKEPERDRKKVKNIKHNGNISFDDVIEIAKIMRPRSIAKELSGTVKEILGTCVSVGCTVDGKDPKDLQEEINSGDIDIPNE
What is the function of this protein?
Binds directly to 26S ribosomal RNA.
What are the official names of this protein?
60S ribosomal protein L12-3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RL17_SHEB2
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTVAKAKELRRVVEPLITLAKSDSVANRRLAFARTRDAEVVGKLFTELGPRYQERPGGYTRILKCGLRAGDKAPMAYIELVGRPEAAQAVDVEAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: HIS4_AZOPC
Sequence: MIEIILAIDIIEGKAVRLTQGDYKQKKIYNQDPLEVAKKFEDYGIRRLHLVDLDGAKANFIVNYKILERIASHTSLIIDFSGGLKSDSDLKIAFNSGAKMVTGGSIAVKNPKIFKNWINKFGANCILLGADCRNNKIAVNGWTEETNEEILPFIKKWRKYGITKVICTDISKDGMLKGTSTELYKTIKKEDTSIYLIASGGVSCIYDIDMLQEAGLSGVIIGKAIYESKIQLKELKKYAC
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APM1_ARATH
Sequence: MDQFKGEPRLPKFAVPKRYDLRLNPDLIACTFTGTVAIDLDIVADTRFIVLNAADLSVNDASVSFTPPSSSKALAAPKVVLFEEDEILVLEFGEILPHGVGVLKLGFNGVLNDKMKGFYRSTYEHNGEKKNMAVTQFEPADARRCFPCWDEPACKATFKITLEVPTDLVALSNMPIMEEKVNGNLKIVSYQESPIMSTYLVAIVVGLFDYVEDHTSDGIKVRVYCQVGKADQGKFALHVGAKTLDLFKEYFAVPYPLPKMDMIAIPDFAAGAMENYGLVTYRETALLYDEQHSAASNKQRVATVVAHELAHQWFGNLVTMEWWTHLWLNEGFATWVSYLATDSLFPEWKIWTQFLDESTEGLRLDGLEESHPIEVEVNHAAEIDEIFDAISYRKGASVIRMLQSYLGAEVFQKSLAAYIKNHAYSNAKTEDLWAALEAGSGEPVNKLMSSWTKQKGYPVVSAKIKDGKLELEQSRFLSSGSPGEGQWIVPVTLCCGSYEKRKNFLLESKSGAYDLKELLGCSIADGSDKINGTCSWIKINVDQAGFYRVKYDDSLAAGLRNATESQSLTSIDRYGILDDSFALTMARQQSLASLLTLCSAYKKELDYTVLSNLIAISYKVVKIGADANQELMSGIKHFFIGVFQFAAGKLGWDPKQGESHLDAMLRGEVLTALAVFGHDETLKEAVRRFDAFLADRNTPLLPPDIRRAAYVAVMQRANKSDKSGYESLLRVYRETDLSQEKTRILGSLASCPDPTIVQDVLNFVLSDEVRNQDALYGLSGVSWEGREVAWKWLQEKWEYIGNTWGSGFLITRFISAVVSPFASFEKAKEVEEFFATRSKPSMARTLKQSIERVHINANWVESIKKEDNLTQLVAQLSSN
What is the function of this protein?
Metallopeptidase that binds to the auxin transport inhibitor N-1-naphthylphthalamic acid (NPA).  Required for embryonic and seedling development as well as cell cycle progression.  Homodimerization is required to proper localization and activity.  May play a negative role in the regulation of PIN auxin transport proteins.
What are the official names of this protein?
Aminopeptidase M1, Alpha-aminoacylpeptide hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Cytoplasm. Note=The dileucine internalization motif may be involved in intracellular sequestration.
Protein: BIRC2_HUMAN
Sequence: MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
What is the function of this protein?
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis.  Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.  The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1.  Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation.  Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs).  Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.  Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.  Can stimulate the transcriptional activity of E2F1.  Plays a role in the modulation of the cell cycle.
What are the official names of this protein?
Baculoviral IAP repeat-containing protein 2, Cellular inhibitor of apoptosis 1, C-IAP1, IAP homolog B, Inhibitor of apoptosis protein 2, hIAP-2, hIAP2, RING finger protein 48, RING-type E3 ubiquitin transferase BIRC2, TNFR2-TRAF-signaling complex protein 2.
What is the protein family that this protein belongs to?
Belongs to the IAP family.