PharMolix/UniProtQA huggingface dataset:
Protein: PAN3_YEAST
Sequence: MDKINPDWAKDIPCRNITIYGYCKKEKEGCPFKHSDNTTATTINDVPPPIDVGEATTPTMTSVPKFNAKVSASFTPMTVGSDSLTTVTNTTSAATNATGNIAMAATSATASTVNPMINPIVNSSLVNNNNNNSNISISIPTTASSSNYDPFNAPIFTPSSTSSIHTNANAHSFPFPSIANSGGININATDDNSNNMSMANNVPPPMQPPPIESSNLKYPRIYPPPHSLLQYHLYAPEQPSSLKSLLKPNERSADQLFIPNNIREDLTKKNLSILQVFPSSGKVIPSIVQDYFNLVPLNFNNNDFLNKTTLFKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNWRKVLITGDPGRIKLSHCNFMDLLFNDDTDTVVSSGGSTIEGQQQLDYKYLGELLFNLSINIENSNNNTAPKEYRLEEITPQSIDDMRQIDDKFKDVLKYLISDNGDSKKSIHDLTSHFYDKMFMVLESSQTYTEYMESVLSRELENGRLFRLVNKLNCIFGRIESRIDINWSESGTKFPIILFYDYVFHQVDSNGKPIMDLTHVLRCLNKLDAGIQEKLMLVTPDELNCIIISYKELKDLIESTFRSITQ
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs.  PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.  PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit PAN3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLUC_ECOLI
Sequence: MKTETPSVKIVAITADEAGQRIDNFLRTQLKGVPKSMIYRILRKGEVRVNKKRIKPEYKLEAGDEVRIPPVRVAEREEEAVSPHLQKVAALADVILYEDDHILVLNKPSGTAVHGGSGLSFGVIEGLRALRPEARFLELVHRLDRDTSGVLLVAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKSVQAPLLKNILQSGERIVRVSQEGKPSETRFKVEERYAFATLVRCSPVTGRTHQIRVHTQYAGHPIAFDDRYGDREFDRQLTEAGTGLNRLFLHAAALKFTHPGTGEVMRIEAPMDEGLKRCLQKLRNAR
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase C, 23S rRNA pseudouridine(955/2504/2580) synthase, rRNA pseudouridylate synthase C, rRNA-uridine isomerase C.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: PMGT2_DANRE
Sequence: MNLPAVLNGLLVSVVAALLWKYVRLVEHTSQLEEELQLTRQSQEFSQVRIDYHGALLALQEHGTRMVCTGKMHTDRICRFDYLCYCTEAEEFVFFHSNASVMLPNLGSRRFQPALLDLSSVEDHNTQYFNFLELPAAALKFMPKPVFVPDVTLILNRFNPDNLMHIFHDDLLPVYYTMQQYSDLDDEARLVFMEGWGEGAHFDLYRLLSSKQPLLKDQLKTFGKLMCFTKSYVGLSKMTTWYQYGFVQPQGPKANILISGNEIRQFASFLMERLNITREEEEEDDDYIVVFKRTTNRLILNEAELLLALAQEFQMRTVTVSLEEQSFDNIIQIISRAAMLVSMHGAQMITSMFLPRGAAVVELFPYGVNPEQYTPYKTLASLPGMDLQYVAWRNTMEENTVTFPDRPWDQGGIVHLEKEEQERILASKEVPRHLCCRNPEWLFRIYQDTTVDLASFLDVLRDGLKKLNLKKAKVASTVHPGRVREPKCQTSVQATNEAKLSVSWQIPWNLKYLKVKEVKYEVWIQEQGENTYMPYILPHQNYTFSENIKPFTTYLVWVRCIFNKNLLGPFADVLICKT
What is the function of this protein?
O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein.  Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity).
What are the official names of this protein?
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2, POMGnT2, Extracellular O-linked N-acetylglucosamine transferase-like, Glycosyltransferase-like domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 61 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: TFF2_PIG
Sequence: EPQRPAPGHPPPAGAVCLTGAQKPAACRCSRQDPKNRVNCGFPGITSDQCFTSGCCFDSQVPGVPWCFKPLPAQESEECVMEVSARKNCGYPGISPEDCARRNCCFSDTIPEVPWCFFPMSVEDCHY
What is the function of this protein?
Inhibits gastrointestinal motility and gastric acid secretion.  Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.
What are the official names of this protein?
Trefoil factor 2, Pancreatic spasmolytic polypeptide, PSP, Spasmolytic polypeptide, SP.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBL_FAGEA
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y883_MYCBP
Sequence: MVRADRDRWDLATSVGATATMVAAQRALAADPRYALIDDPYAAPLVRAVGMDVYTRLVDWQIPVEGDSEFDPQRMATGMACRTRFFDQFFLDATHSGIGQFVILASGLDARAYRLAWPVGSIVYEVDMPEVIEFKTATLSDLGAEPATERRTVAVDLRDDWATALQTAGFDPKVPAAWSAEGLLVYLPVEAQDALFDNITALSAPGSRLAFEFVPDTAIFADERWRNYHNRMSELGFDIDLNELVYHGQRGHVLDYLTRDGWQTSALTVTQLYEANGFAYPDDELATAFADLTYSSATLMR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase BCG_0883.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: RF1_ECOL6
Sequence: MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTM1_CHATD
Sequence: MDAPMEDAPAPVAQVKVIFTTTEPDLELPESKRQLLVPADIRRYGLSRILNSESMLDTGSIPFDFLINGSFLRSSLEDYLTSNGLSLETTLTLQYVRSLIPPVYEASFEHDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVWDKLGIFSGGEDKKVQVNRGRNIVTEQK
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein YTM1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR12/YTM1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: PUAC_STRAD
Sequence: MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA
What is the function of this protein?
Detoxification of puromycin.
What are the official names of this protein?
Puromycin N-acetyltransferase.
Protein: DEOB_ECO57
Sequence: MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDHENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTNGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHTREHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK14_OENGL
Sequence: MIQPQTRLNVADNSGARELMCIRIIGASNRRYAHIGDIIVAVIKEALPSTSLERSEVVRAVIVRTCKELKCDDGIIIRYDDNAAVVIDQEGNPKGTRVFGAIAHELRELSFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRUA_BORAP
Sequence: MKKILAEIAYDGSMYHGFQIQPTKPTIQGEIEKALMKINKKKIKIHSSGRTDKGVHAKRQIITFDININIQLNNLKKALNAILLKPGIKILKLKHVKNSFHPRFNAQKRKYSYCILNSDNYYPWESYQAYYVNKKLNINNLNQMAKILIGNHDFTTFSCIKDKSKSKFRHIHSAKFKKKGKYIIFEIIGSSFLWKMVRSIIGTMLDIEIKNESISTFETILKSKNRNLARTTAPANALFLDKVYYE
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: CX7B2_HUMAN
Sequence: MMFPLARNALSSLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQIGIEWNLSPVGRVTPKEWKHQ
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7B2, mitochondrial, Cytochrome c oxidase polypeptide VIIb2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIb family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: GATA8_ARATH
Sequence: MIGTSFPEDLDCGNFFDNMDDLMDFPGGDIDVGFGIGDSDSFPTIWTTHHDTWPAASDPLFSSNTNSDSSPELYVPFEDIVKVERPPSFVEETLVEKKEDSFSTNTDSSSSHSQFRSSSPVSVLESSSSSSQTTNTTSLVLPGKHGRPRTKRPRPPVQDKDRVKDNVCGGDSRLIIRIPKQFLSDHNKMINKKKKKKAKITSSSSSSGIDLEVNGNNVDSYSSEQYPLRKCMHCEVTKTPQWRLGPMGPKTLCNACGVRYKSGRLFPEYRPAASPTFTPALHSNSHKKVAEMRNKRCSDGSYITEENDLQGLIPNNAYIGVD
What is the function of this protein?
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.  May be involved in the regulation of some light-responsive genes (By similarity).
What are the official names of this protein?
GATA transcription factor 8.
What is the protein family that this protein belongs to?
Belongs to the type IV zinc-finger family. Class A subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPG_THEAB
Sequence: MTKEINIKNVKIGGKNSIVIQSMTNTKTEDIKSTLQQIQNLYNAGCELVRVSAPTFEAAKALKTITKESPIPVIADIHFDYKLAIESIKNGASKVRINPGNIGNDEKVKEIIKVAKEYNVPIRVGANSGSIPKELETLPKIDALCESALKEVRLLEKFDFENIVISVKSSDVIETIKAYEKISKMTDYPLHIGVTEAGTYEWAIIKSSAALGYLLYKGIGDTIRISIAGDPVKEVLAAKKLLISLNLRKGIQIIACPTCARTTIDVEKWASIIEKRFSKVEKNIKIAVLGCVVNGIGEGKDAEIGIAGVQNGFLLFYKGKIVGTFKKEEIFQVLEDYIIKVEVE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: SDRM_STAAN
Sequence: MRLKSIITVIALILIMFMSAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLSRFKIIYVAIAGLLLFSIGSFMCGLSTNFTMLIISRVIQGFGSGVLMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVIWTFHFPEEETVAKSKFDTKGLTLFYVFIGLIMFALLNQQLLLLNFLSFILAIVVAMCLFKVEKHVSSPFLPVVEFNRSITLVFITDLLTAICLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHRIEAKLSRKVIYLLSFTLLLVSSIIISFGIKLPVLIAFVLILAGLSFGYIYTKDSVIVQEETSPLQMKKMMSFYGLTKNLGASIGSTIMGYLYAIQSGIFGPNLHNVLSAVAVISIGLIVLWVVFFKEQSSQSKE
What is the function of this protein?
Energy-dependent drug efflux pump that increases resistance to antimicrobial agents such as norfloxacin, acriflavine and ethidium bromide.
What are the official names of this protein?
Multidrug efflux pump SdrM.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AAEB_SHIFL
Sequence: MGIFSIANQHIRFAVKLATAIVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGFLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRIENSYAWGLAGYTALIIVITIQPEPLLTPQFAVERCSEIVIGIVCAIMADLLFSPRSIKQEVDRELESLLVAQYQLMQLCIKHGDGEVVDKAWGDLVRRTTALQGMRSNLNMESSRWARANRRLKAINTLSLTLITQSCETYLIQNTRPELITDTFREFFDTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWVAAATRYQLLKRGVISNTKINATEEEILQGEPEVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCISLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAVSAMTTNVARRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSAFHRQMRRTADHVISARSDDKRRRYFGQLLEELEIYQEKLRIWQAPPQVTEPVHRLAGMLHKYQHALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLPK_SYNY3
Sequence: MTAKHNQYVMALDLGTTGNRAILFDYEGNIVGQAYKELTQFYPKAGWVEHDALEIWRDTKTVMQEVVQKTAIQPQQIVAIGLTVQRETCLLWDKTTGQPLHPAIVWQDRRTAHFCGELTAAGYVDEIYERTGLVLDAYFSGTKLHWLLDWVKQSKSVDPANLLAGTIDSWALWNLTGGKVHRTDHSNASRTMVLNLDSLIWDEKLLDLFTIPAQIMPEVQPSLSYFGVTDPEILGVEIPITAIFGDQQAALYAHGCDRPGLLKCTYGTGAFLVANTGQTVTRSQHRLLSTVAWTQTNRDKSLTRDYALEGSMFTAGSCVQWLRDKLGLIESAAASESLARSVDSNGGVYFVPALSGLGAPHWDMNACGAFLGLTAGVTKAHLVRSVLEAIAFQAREVVEAINQDSPAPIQQLKVDGGACNNDFLMQCQADVLGIPVERPAVLDATAQGAAFGAGLKIGWNQLQIRFFRTFHHGTISLICLQFLPMRIQEGVSVDQ
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: PSRC1_MOUSE
Sequence: MEDLKEDIKFIVDETLDFGGLSPSDSHEEEDITVLVSPEKPLRRGLAHRSNPNEVAPALQGVRFSLGPLSPEKLEEILDEANRLAAQLEECALKDRERAGTGPGRPSPRGKPSPRRETFVLKDSPVRDLLPTVSSWSTPPPSSLAGLRSSDKKGSARAVRVASGKKPSSIKKESPTCNLFPASKSPGRSPLAQPILPPRRKTGFGARTTASPPIPVRPVPQSSASNSQCSSRLQGAAVKSSSRLPVPSAIPKPATRVPLIGRSLPPGKGALAPDSLSTQKGHPSAIGHRASVSQKTNLPTTSAARGRTTSAARGRAQPLRKAAVPGPTR
What is the function of this protein?
Required for normal progression through mitosis.  Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase.  Plays a role in the regulation of mitotic spindle dynamics.  Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores.  Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles.  May participate in p53/TP53-regulated growth suppression (By similarity).
What are the official names of this protein?
Proline/serine-rich coiled-coil protein 1.
What is the protein family that this protein belongs to?
Belongs to the PSRC1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase (By similarity).
Protein: ODFP1_MOUSE
Sequence: MAALSCLLDSVRRDIKKVDRELRQLRCIDEISSRCLCDLYMHPYCCCDLHPYPYCLCYSKRSRSCGLCDLYYPCCLCDYKLYCLRPSLRSLERLRRTTNRILASSCCSSNILGSVNVCGFEPDQVKVRVKDGKVCVSAERENRYDCLGSKKYSYMNICKEFSLPPCVDEKDVTYSYGLGSCVKIESPCYPCTSPCNPCNPCSPCSPCAPCACGPCGPCGPCGPCGPCDPCNPCYPCGSRFSCRKMIL
What is the function of this protein?
Component of the outer dense fibers (ODF) of spermatozoa.  ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.
What are the official names of this protein?
Outer dense fiber protein 1.
Protein: FABV_BURL3
Sequence: MIIKPRVRGFICVTTHPVGCEANVKEQIDYVTSHGPIANGPKKVLVIGASTGYGLAARISAAFGSDADTLGVFFERAGSETKPGTAGWYNSAAFEKFATEKGRYARSINGDAFSDHVKQVTIDTIKQDLGKVDLVVYSLAAPRRTHPKTGETISSTLKPIGKTVTFRGLDTDKEVLRDVTLEPATQEEIDGTVAVMGGEDWQMWIDALDEAGVLADGAKTTAFTYLGEQITHDIYWNGSIGEAKKDLDKKVLSIRDQLAAHGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKTMKETGTHEGCIEQVYGLFKDSLYGATPHVDEEGRLRADYKELDPQVQAKVVAQWDHVTNDNLYELTDFTGYKTEFLRLFGFEIAGVDYDADVNPDVKIPGIIDTTV
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: PURQ_KORVE
Sequence: MKFGVLIFPGSNCDHDAHWVLGQVAKQPVTFLWHESHDLENCDAIVVPGGFAYGDYLRTGAIAKFSPVMEAVRKFADKGGLVIGICNGFQILTESGLLPGALLRNEGLKYICKPVNIRVETTDAPFTQGLKKGEVLQVPIGHMEGNYVCDDATLAELKKQDRIVFRYATPDGQITREANPNGSIENIAGICNEGRNVLGMMPHPERASENELGMTDGFRIFESMVGAMAKR
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKR3_SCHPO
Sequence: MQNEYVDMNSSSEDSDGDSILEEGRLRPSFRGQQKERDMLGIFGEEDEDGFHNSGIGSARLRRKNISFVEKSEQVKANKQVTADDLLEAHSIPQLKNKNDEVSQAKNIPKMKFNTTGFGAKMLEKMGYKQGQGLGANAEGIAEPVQSKLRPERVGLGAVRERTEKQRKEAIARGEISDSEDEKHTVKQKPLREKKKKPLKSSEEISKDMGSYNLPRFLASLIDASLNDTKEIEFVTSNKEELGLEGRDMSTSGINQLSRLARVECEHHASAWQQLQARRAYVKMELKRVTTEFDEKSVEISRLEKLLGKVMEVKSRSMEFTVPEAEIDVIEKRLQPLNNLIETLPVEFSEASMHFELDSVAVSILAFVLSEPIKNWDVWKHPYFMLESFLSWKNSLYSKDFRPKREESSTFMDIDVEFDDELEGQSLTHYESFMMFVWKKKIGEELKKWIIQDSLKALQLLEAWDPVVPEKVKDSLIQDDILPRLKDAVSKWNPKLKLKKNDSLHHCIFPWLPYLEKHADSLLQSVLVQFSLILSPWKIKNGSIDDFSVWRSAFANDALDRLLEKVILPKLEKLMDEELVIDPSNQDLEIFFIILSWKGSFKAMVFGQLFADHFFPKWLETLYQWLTEAPNFDEASEWYTWWKSVFPKDLLSNAYIQQGFSKGLDMMNECLENKSITAPLPFAKDSTKGVNLQFSKEKHEFTAESDDTTSYDEPLVSFRELVEEFCAENSLLFVPLRRSHLSTGSALFRISTQASKARGITVYLRNDIIWKKSPGASEDTPYDPIGFNEILLMFNNN
What are the official names of this protein?
G-patch domain-containing protein C1486.03.
What is the protein family that this protein belongs to?
Belongs to the TFP11/STIP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: RS11_CARHZ
Sequence: MMARRTKARKKEKKHVEQGVAHIKSTFNNTIVTITDPQGNTLSWASAGTVGFEGTRKGTPFAAQLAAEKAAKEAMEFGVKTVEVYVKGPGAGREAAIRSLQAAGLEVSLIKDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: HGXR_PLAFG
Sequence: MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to the N(9) of hypoxanthine, guanine or xanthine, leading to IMP, GMP and XMP, respectively.  Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
What are the official names of this protein?
Hypoxanthine-guanine-xanthine phosphoribosyltransferase, HGPRT, HGXPRT, HGXPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.