PharMolix/UniProtQA huggingface dataset:
Protein: YQGF_BURCJ
Sequence: MSGASARDATLLAFDYGEKRIGVAIGNALTRSARALVVIQNLNREHRFKAVGDLLAEWRPDALVVGLPMHPDGTPHDMTQQAKRFGNQLNGRFGLPVTWVDERYSSVEAEAGLRERNVRGRARTDMLDAEAARVILQQYLDQLSDHEHH
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_NAUPA
Sequence: MSRIGKQPVKLASGLEAKLEGNKLIIKKGQDEKVIDTKGVVKVNINGDELTFEPVEETKFAKAMWGTVRALANNAVIGLTQGFEKKLEINGVGYRAQVKGNILELQLGYSHPINFEIPKGITITVEKNIITVKGSDKQQVGQVASEIRSFRKPEPYKGKGVKYVDEHIIRKAGKTAKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: XERC_TREDE
Sequence: MNEVFESYLTYSAGVRQFTKATIDSYKNDLIIFEEWLKELDLNIFELKASDIRIFIAELADKKIAPASINRMMSTLRGFYKYALRFNLTKMNPISSVRNLKLAQKLPVFMFPKQAQEFCRLPSNAGILWETRDAALFASLYSTGCRVSELAGLDIKDLDKTLSYAIVFGKGKKERKVFFAEFAKEYLREYLKERSDLVEKFKGQVQKDGKGKIRDTLFINQKAQPLTSRGIRYIIDRYVELSPELKHLSPHAFRHSFASTLITRGADIRVVQELLGHESVSTTQRYTHITAEQLQNLYKTAHPHS
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GL8D1_BOVIN
Sequence: MSFRKVNIVILVLAVALFLLVLHHNFLGLSSLLRNEVSDSGIVGLQPVDFIPNAPQRVVDGREEEIPVVIAASEDRLGGAIAAINSIQHNTRSNVIFYIVTLNGTADHLRSWLSSSNLKRIRYKIVNFDTKLLEGKVKEDPDQGESIKPLTFARFYLPILVPRAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSTSAKVVIRGAGNQYNYIGYLDYKKERIRELSMKASTCSFNPGVFVANLTEWRRQNITNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTASYTDVWEKWYIPDPTGKFSLIRRHVEISNTK
What are the official names of this protein?
Glycosyltransferase 8 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RNAS1_EUDTH
Sequence: KESAAAKFZRZHMBSSTSSASSSNYCNQMMKSRNLTQDRCKPVNTFVHESLADVQAVCSQKNVQCKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQAQKHIIVACEGNPYVPVHFDASV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPOA_ECOL6
Sequence: MVPSTFSRLKAARCLPVVLAALIFAGCGTHTPDQSTAYMQGTAQADSAFYLQQMQQSSDDTRINWQLLAIRALVKEGKTGQAVELFNQLPQELNDTQRREKTLLAAEIKLAQKDFAGAQNLLAKITPADLEQNQQARYWQAKIDASQGRPSIDLLRALIAQEPLLGAKEKQQNIDATWQALSSMTQEQANTLVINADENILQGWLDLQRVWFDNRNDPDMMKAGIADWQKRYPNNPGAKMLPTQLVNVKAFKPASTNKIALLLPLNGQAAVFGRTIQQGFEAAKNIGTQPVVAQVAAAPAADVAEQPQPQTVDGVASPAQASVSDLTGEQPAAQSVPVSAPATSTAAVSAPANPSAELKIYDTSSQPLSQILSQVQQDGASIVVGPLLKNNVEELLKSNTPLNVLALNQPENIENRVNICYFALSPEDEARDAARHIRDQGKQAPLVLIPRSSLGDRVANAFAQEWQKLGGGTVLQQKFGSTSELRAGVNGGSGIALTGSPITPRETTDSGMTTNNPTLQTTPTDDQFTNNGGRVDAVYIVATPGEIAFIKPMIAMRNGSQSGATLYASSRSAQGTAGPDFRLEMEGLQYSEIPMLAGGNLPLMQQALSAVNNDYSLARMYAMGVDAWSLANHFSQMRQVQGFEINGNTGSLTANPDCVINRKLSWLQYQQGQVVPAS
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
What are the official names of this protein?
Penicillin-binding protein activator LpoA, PBP activator LpoA.
What is the protein family that this protein belongs to?
Belongs to the LpoA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: HUTH_STAAR
Sequence: MTLYLDGETLTIEYIKSFLQQQSKIEIIDDALERVKKSRAVVERIIENEETVYGITTGFGLFSDVRIDPTQYNELQMNLIRSHACGLGEPFSKEVALVMMILRLNTLLKGHSGATLELVRQLQFFINERIIPIIPQQGSLGASGDLAPLSHLALALIGEGKVLYRGEEKDSDDVLRELNRQPLNLQAKEGLALINGTQAMTAQGVISYIEAEDLGYQSEWIAALTHQSLNGIIDAYRHDVHAVRNFQEQINVAARMRDWLEGSTLTTRQAEIRVQDAYTLRCIPQIHGASFQVFNYVKQQLEFEMNAANDNPLIFEEANATFVISGGNFHGQPIAFALDHLKLGVSELANVSERRLERLVNPQLNGDLPAFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSITSSANQEDHVSMGTTAARHGYQIIENARRVLAIECVIALQAAELKGVEGLSPKTRRKYDEFRSIVPSITYDRQFHKDIEAVAQYLKQSIYQTTACH
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUV3M_ORYSJ
Sequence: MAVAAALLRRRALYSALASPSWLHDTSSCYICSISGTHSLVNHPNLRLQRGYHNSGKFDLTDLTHPHIWYPNAREKKRNVFLHVGPTNSGKTHNALKRLEASSSGVYCGPLRLLAREVAQRLNKANVPCNLITGQEREEIEGAKHSSVTVEMADMTTEYQCAVIDEIQMVGCRSRGFSFTRALLGLCSDELHVCGDPAVVPLIQRILEPTGDVVTVQYYERLSPLVPLKTTLGSFSNIKAGDCVVTFSRRSIYMLKRRIEMGGKHLCSVVYGSLPPETRTKQATMFNDQDSNLNVLVASDAIGMGLNLNISRIIFSTLEKFDGICNRELTVAEIKQIAGRAGRYGSKFPVGEVTCLNSDHLPLLHSALKSPSPIIERAGLFPTFDVLSLYSRLHGTDFFQPILERFLDKAKLSPDYFIADCEDMLKVAAIVDELPLGLYDKYLFCLSPVDIRDDISTKGLIQFAENYAKKGIVRLKEIFTPGTLQVPKSHNQLKELESIHKVLELYVWLSFRLEDSYPDRELAASQKSICSMLIEEYLERSGWQQNGRKDFLQKPKRLHQEYDASQLRKYFQEIDVRSK
What is the function of this protein?
Major helicase player in mitochondrial RNA metabolism.  Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (By similarity).  ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction (PubMed:23808500).  Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates (By similarity).  Confers salinity and drought stress tolerances by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormones levels such as gibberellic acid (GA(3)), the cytokinin zeatin (Z) and indole-3-acetic acid (IAA) (PubMed:23808500, PubMed:25184028).
What are the official names of this protein?
ATP-dependent RNA helicase SUV3, mitochondrial, OsSUV3, Protein SUPPRESSOR OF VAR 3.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
Protein: EP153_ASFB7
Sequence: MYFKKKYIGLIDKNCEKKILDDSSTIKICYILIGILIGTNMITLIYNFIFWDNYIKCYRNNDKMFYCPNDWVGYNNICYYFSNGSFSKNYTAASNFCRQLNGTLANNDTNLLNLTKIYNNQSMYWVNNTVILRGDNKYSQKVNYTDLLFICGK
What is the function of this protein?
Down-regulates MHC-I expression by impairing the appropriate configuration or presentation into the plasma membrane of the latter (PubMed:21069396).  Participates in viral hemadsorption, which may help viral spread (PubMed:10639320).  Reduces the transactivating activity of host TP53, thus inhibiting apoptosis (PubMed:15262504).  Non-essential for virus growth in swine macrophage cell cultures (By similarity).
What are the official names of this protein?
Lectin-like protein EP153R, pEP153R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus lectin-like protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: NIKR_DESPS
Sequence: MLKRFSISLDDNLLEIFDQHIAEKAYNNRSEAIRDLIRKNFVLKEWEEDRDVMGVISLIYDHHQSQLQKKVTDLQHDFHHHIVSTTHVHMDHDNCLEVIIVKGRAGDVIELADGLAALKGVRDSNLAMNSTGKSLH
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: ERA_BORPD
Sequence: MSNTPFRTGFVAVVGRPNVGKSTLTNALIGSKISIVSRKAQTTRHRIHGVLTREHEQFVFVDTPGFQTRHGGAMNRMMNRVVTQALAEVDVVVHVVEAGKWTDGDAKLLPLLPDARRTILVVSKIDAVKRRDELFAFVSKIVAQHPYDAVVPVSAVKSQQLDQLLDEIAARLPEGEPLFEEDTLTDRPMRFIAAELLREKIFRLVGDELPYGCTVVIEQWEETDKNLRVAACVVVERDSHRPILLGAGGVHMKRIATEARQDIAKLVDKPVHLEVYIKVRKGWSDRESALRDLGYE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: SIG1S_REOVJ
Sequence: MENQPTRNTRSRKLRNKLKTSLLMSTGSVTSLIQSKDNWVDYLYACQPLNRELVRTAIELIDSSEMSPAYRLALAESIRVYPSWVTESMLQNSELASWIQSRIISLSEHQDWKLKYQPLLMTLDH
What are the official names of this protein?
Protein sigma-1-small, Sigma1s, Sigma-s, Sigma1NS, Sigma1bNS, p14.
What is the protein family that this protein belongs to?
Belongs to the orthoreovirus sigma-1s protein family.
Protein: HEM3_YERPS
Sequence: MLDKIIRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKGLFVKELELALLDGRADIAVHSMKDVPIAFPEGLGLVAICEREDPRDAFVSSHYAHLDDLPAGSVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLDNGDYQAIILAVAGLKRLGLETRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEGGCQVPIGSYAELEGDTLWLRALVGAPDGSQMIRGERRGPAAEAEQMGIELADELLSRGAREILAAVYLDNPAR
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: LEPA_PROMP
Sequence: MTDISVSKIRNFCIIAHIDHGKSTLADRLLQDTGTVKQRDMQDQFLDSMDLERERGITIKLQAARMKYKAKDSQEYILNLIDTPGHVDFSYEVSRSLQACEGALLVVDASQGVEAQTLANVYLALENNLEIIPVLNKVDLPGADAEKIKQEIEEIIGLDTSNAINCSAKTGEGIEDILEAVVSRIPHPQNEVKSLTKALIFDSYYDPYRGVIVYFRVIAGSINKKDKILLMASKKNYELDEIGIMAPDEKQVNELHAGEVGYLAASIKSVADARVGDTITLFNSPAKDPLPGYKTANPMVFCGLFPTDADQYPDLRESLEKLQLSDAALKYEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYDLDLIVTAPSVIYKVNLNDQEDILIDNPSTIPDPQSRESIEEPYVKMEIYSPNEFNGTLMGLCQERRGVFIDMKYITTDRVTLIYEIPLAEVVTDFFDQMKSRTQGYASMEYHLIGYRKNDLVRLDVLINSERADPLTSIVHKDKAYGIGRGLVEKLKELIPKQQFKIPIQASIGSRIIASESISALRKDVLSKCYGGDISRKKKLLKKQAKGKKRMKAMGKVDVPQEAFMAVLKLNQ
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LIPA_AROAE
Sequence: MDSTARKQRGADKTARIPIKIVPAERLKKPEWIRIRLGAGHEAERFNEIKASLREHKLHTVCEEASCPNIHECFGKGTATFMIMGDICTRRCPFCDVGHGRPEPLNANEPQELAATIGAMRLNYVVITSVDRDDLRDGGAQHFVDCIRETRAASPKTRIEVLVPDFRGRLDVALEIFDQAPPDVMNHNLETVPRLYKQARPGADYAYSLRLLKEFKARHPDVPTKSGLMVGLGETDDEILDVLRDLRAHDVEMLTIGQYLQPSTGHLPVLRYVHPDTFKMFETEALAMGFKNAACGPMVRSSYWADQQAYGAGVV
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_PYRAR
Sequence: MDLKALLRKLGNGLRLTADEAYLLGRGILSGSLCDVEVAASLTAMRVRGESPEEVAGFVKMAREFAVRVPLRIEAVDTAGTGGDGAGTINLSTAAAIVAAAAGAKVLKHGNRSASGLFGSADFMEAVGYNLEVGPEKAAELVEKVGFAFVFAPRYHPAFAKVAPVRRALPFRTIFNIVGPLANPGLVKRQLIGVAEERLLEVVAAAAAELGFEHAVVVHGSGVDEVSSEGATTVYEVKRGSLERYQIAPEDLGAPRVPIPRASDKEEAVAKALAGLRGELREASVAIALNAAFALYVAGVVGDPRDGFELAMRAIQEGVAYRKLVEAVEASRT
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: LEUD_METMA
Sequence: MKGRAWKFGDDVDTDAVIPGRYLIFNTPGELAKYTFEGVRPDFAKNVHENDIVVAGSNFGCGSSREHAPLALKGSKVSCVIAKSFARIFFRNAINIGVPVLECPDTDKIDDGDELEVDISTGVIQNRTKGETYQATPLPDFVREIVDEGGLIEYARKLVSER
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: LHPL6_MOUSE
Sequence: MASSLTCTGVIWALLSFLSAATSCVGFFMPYWLWGSQLGKPVSFGTFRRCSYPVHDESRQMMVMVEECGRYASFQGIPSTEWRICTIVTGLGCGLLLLVALTALMGCCVSELISRTVGRVAGGIQFLGGLLIGAGCALYPLGWDSEEVRQTCGYISGQFDLGKCEIGWAYYCTGAGAAAAMLLCTWMACFSGKKQKHYPY
What are the official names of this protein?
LHFPL tetraspan subfamily member 6 protein, Lipoma HMGIC fusion partner.
What is the protein family that this protein belongs to?
Belongs to the LHFP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RLMH_MAGSA
Sequence: MRLLIAAVGKAKAGPEQDLFRQYCRRLSPPPVLKEVEEKRPLAGPQLKAREAELLLATLPEGAKVVALDEKGRDIGSVDFAHRLRDWRDSGCQDVAFLIGGADGHGDAVRERADLLLSFGRMTWPHMLVRALLAEQLWRAHSILTGHPYHRP
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_AERHH
Sequence: METQRLRIAMQKSGRLSQDSQALFKSCGLKINLREQRLIAHVENMPIDILRVRDDDIPGLVMEGVVDLGIIGENVLEEVQLIRASQGQPFAVKTLKQLDFGGCRLSLAVPDDVTYTGPQSLAGKRIATSYPGLLKRFFDEKGLSFKSVMLGGSVEVAPRAGLADAICDLVSTGATLEANGLKEVEVIYRSKAVLVQAPNPLSDAKQKIIDTLLPRIQGMQQARESKYIMLHAPKDKLDAITDLLPGAERPTIMQLAGETNQVALHVVSSETLFWETMEQLKALGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMPS4_HUMAN
Sequence: MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL
What is the function of this protein?
(Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.
What are the official names of this protein?
Transmembrane protease serine 4, Channel-activating protease 2, CAPH2, Membrane-type serine protease 2, MT-SP2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Transmembrane protease serine 4 catalytic chain]: Secreted. Note=Activated by cleavage and secreted.
Protein: RL16_ANASK
Sequence: MLQPARTKYRKMQKGRMRGKAYRGSDLAQGEYGLQATECGRLTSRQIEAARVAITRYVKRGGKLWIRVFPDKPITKKPAETRMGTGKGNVEFYVAVIKPGRVLYELAGVDDASAKKAFHLAAHKLPVATKMVKRGETL
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RUVC_NITWN
Sequence: MISSPIRILGIDPGLRRTGWGVLEIDGNRLMFVGCGSVETREHMALASRLLAIHAGLGAVLDQFRPSEAAIEQTFVNKDGVATLKLGQARGVAMLAPALFGIAVAEYAPNQVKKTVVGAGHADKAQIQAMLKILLPKADPKSADAADALAIAITHAHHRKSAALAARMKAVG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: THIG_PSYCK
Sequence: MSDNTSTATQSTPLLQDTFTVGSRTFSSRLLVGTGKYKDMTETGAAIGASAAEIVTVAIRRTNIGQNSNEPNLLDVISPDKYTILPNTAGCFDAETAIRTCKLARELLGGHNLVKLEVLGDEKTLYPNVMETLKAAKVLIDDGFEVMVYTSDDPIVAQELESMGCVAIMPLGSLIGSGLGLLNRHTLSLIIENAKVPVLVDAGVGTASDAAIAMELGCDGVLMNSAIANAQNPVMMAQAMKHAVWAGRQAFLAGRMPMRKMATASSPQTGYFFQ
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFNA1_BOVIN
Sequence: MEFFWASLLGLCCSLAAANRHTVFWNSSNPKFWNEDYTVHVRIDDYLDIICPHYEDNSVPDAAMEQYTLYLVEHEQYQLCQPQPKDHARWFCKSPKAKHGPEKLSEKFHRFTGFTLSKDFKEGHSYYYISKPIHHQEDRCLRLKVMIAGKITHSPQAHPNAQEKRLPADDPEVQVLHSIGHSAAPRLFPLAWAVLLLPFLLLQIP
What is the function of this protein?
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.  Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  Plays an important role in angiogenesis and tumor neovascularization.  The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.  Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2.  Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation.  Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK.  Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).
What are the official names of this protein?
Ephrin-A1.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. SUBCELLULAR LOCATION: [Ephrin-A1, secreted form]: Secreted.
Protein: RGS4_BOVIN
Sequence: MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHSKKDKVVICQRVSHEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQRKIFNLMEKDSYRRFLKSRFYLDLVNLSSCGSEKQKGAKSSTDCASLVPQCA
What is the function of this protein?
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.  Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein.  Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).
What are the official names of this protein?
Regulator of G-protein signaling 4, RGS4.
Protein: LEUC_YERE8
Sequence: MGKTLYQNKTLYQKLYDAHIVYEAPNETPLLYIDRHLVHEVTSPQAFDGLRAMGRPVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCAEFGVSLYDLNHPFQGIVHVIGPEQGMTLPGMTIVCGDSHTATHGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMKIEVNGEVGPGITAKDIVLAIIGKTGSAGGTGHVVEFCGSAIEALSMEGRMTLCNMAIEMGAKAGLVAPDDTTFNYLKGRQFAPTGEQWEQGVAYWRTLKSDADAKFDTVVTLDAADIAPQVTWGTNPGQVIAVNQIIPAPESFSDPVERASAEKALAYMDLRPGIKLTEVAIDKVFIGSCTNSRIEDLRAAAAVAQGRKVASGVQAIVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLEPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVSGHFADVRDLSAATH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.