PharMolix/UniProtQA huggingface dataset:
Protein: BCKD_RAT
Sequence: MILTSVLGSGPRSGSSLWPLLGSSLSLRVRSTSATDTHHVELARERSKTVTSFYNQSAIDVVAEKPSVRLTPTMMLYSGRSQDGSHLLKSGRYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGGQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
What is the function of this protein?
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways.  Key enzyme that regulate the activity state of the BCKD complex.
What are the official names of this protein?
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, Branched-chain alpha-ketoacid dehydrogenase kinase, BCKD-kinase, BCKDHKIN.
What is the protein family that this protein belongs to?
Belongs to the PDK/BCKDK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Mitochondrion.
Protein: DXR_RHOP2
Sequence: MSAVPLKNTDAAHDGVRSISVLGATGSIGDSTMDLLRAAPEKYRVEALTGNANVAGLAKLAKEFNARFVAVADPARLGELRAALAGTDIAYGAGESAVIEAAARPADWVMAAISGAAGLKPALAAVDRGATVALANKECLVCAGDFFMSRAVAAGSCILPADSEHNALFQALASGNRHELTRVIITASGGPFRTWSAADIEQATLAQALKHPNWSMGQKITIDSASMMNKGLEVIEASYLFALSPDEIDVLVHPQSIVHGMVEFADHSVVAQLGAPDMRIPIAHCLGWPDRIVGRAARLDLAKIGQLTFEAPDFERFPGLRLAYDALRAGNGATTVYNAANEIAVAAFIAQKIRFGAIARLVEDTLNAWIRAGNLAPLGSADDAIAVDHNARKMAATLLPQIAAKAS
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: PKHA8_BOVIN
Sequence: MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSSSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSNKMKHPIVPIHNSLERQMELNSCENGSLNMEINDDEEILVRNKSSLCLKPAETDCSISSEENTDDNITVQGEMMKENGEESLGNHDSDLAQPELHSTSSSPESHWEEDQEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTIKEGDHQKAAFSVGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV
What is the function of this protein?
Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN).  Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation.  Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids.  Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability.  Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity).
What are the official names of this protein?
Pleckstrin homology domain-containing family A member 8, PH domain-containing family A member 8, Phosphatidylinositol-four-phosphate adapter protein 2, FAPP-2, Phosphoinositol 4-phosphate adapter protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus, trans- Golgi network membrane. Membrane; Peripheral membrane protein. Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes (By similarity).
Protein: ARGB_BORPD
Sequence: MTDTPDPAAVSSPAIKAAVLSEALPYIRRFHGKTIVVKYGGNAMTEERLQRSFAHDVVLLKLVGLNPVVVHGGGPQIDDALRRIGKQGTFVQGMRVTDAETMEVVEWVLGGQVQQDIVMMINEVGGKAVGLTGKDGMLIQARKKLMANKENPQEPIDIGFVGDITQVEPAVVKALQDDQFIPVISPIGYGEDGTAYNINADVVAGKMAEVLGAEKLLMMTNTPGVLDKSGKLLRSLSAQTIDELFADGTISGGMLPKIASSLDAAKNGVNSVHIVDGRVPHCLLLEILTDQGVGTMISSH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESR1_PAGMA
Sequence: MYPEDSRGSGGVATVDFLEGTYDYAAPTPAPTPLYSHSTPGYYSAPLDAHGPPSDGSLQSLGSGPNSPLVFVPSSPRLSPFMHPPTHHYLETTSTPVYRSSVPSSQQSVSREDQCGTSDDSYSVGESGAGALAAGFEIAKEMRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQACRLRKCYEVGMMKGGMRKDRGRVLRRDKQRTGTSDRDKASKGLEHRTAPPQDRRKHISSSAGGGGGKSSMISMPPDQVLLLLQGAEPPMLCSRQKLNRPYTEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSIHCPGKLIFAQDLILDRSEGDCVEGMAEIFDMLLATASRFRMLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHDGAAVQNMLDTITDALIHHINQSGCSAQQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRIHRADRPAETWSQADREPPFTSRNSSGGGGGGGGGSSSAGSTSGPRVSHESPTSPGVLQYGGSRSECTHIL
What is the function of this protein?
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
What are the official names of this protein?
Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GNAI2_CHICK
Sequence: MGCTVSAEDKAAAERSRMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYKAVVYSNTIQSIMAIIKAMGNLQIDFGDSSRADDARQLFALACTAEEQGIMPEDLANVIRRLWADHGVQACFNRSREYQLNDSAAYYLNDLERIARADYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIVHSPLTICFPEYTGANKYDEAAGYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.  May play a role in cell division (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-2, Adenylate cyclase-inhibiting G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane.
Protein: MHPA_BURO1
Sequence: MKANNRNRTSVAIVGAGPNGAAMANLLGLYGVDTIVVERAPQIVEFPRAVGIDDEALRLFQTAGLADELSRDIIQNVPLRMFKANGECFADIRPSIREFGWWRRNIFMQHLAERTLRDALARYPHVSLRTGEEVVGLEQDDECVTLQVRAADGQQYELDADYVVAADGGRSPVREMLGIRLAGTTHPMKWVVVDVKNARLDQPCTALNCDPRRPNVCIYLPFNYRRWEFLVFPHEDEEAIAQPESIRALIAPYVDDVDRIEIVRARTYTHHSRVAERFVAGRVALIGDAAHLSPPWIGQGLNAGLRDVGNLAWKLAGVVNGTLHRRVISTYESERRDHAKAMIDLADTFGAMLMPTSRLVAFLRDRFLGLARYAPGLKDYVLQMRFKPMPSYTHGVVVTGTSDAVGRMIVQPDVETADGARRKLDDVLGPWFAIIGWRCDPQACLSDDDRAFWTALGAKFVQIVRSRSGTCREQRIASAHDSVCVEDVDNAMAEWFDRHAAPLVVVRPDRYVAAQTDAAGMAGVTAAFQAFAARQRETADVC
What is the function of this protein?
Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).
What are the official names of this protein?
3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase, 3-HCI hydroxylase, 3-HPP hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: EFEMO_STAAN
Sequence: MKKLTTLLLASTLLIAACGNDDSKKDDSKTSKKDDGVKAELKQATKAYDKYTDEQLNEFLKGTEKFVKAIENNDMAQAKALYPKVRMYYERSEPVAEAFGDLDPKIDARLADMKEEKKEKEWSGYHKIEKALYEDKKIDDVTKKDAQQLLKDAKELHAKADTLDITPKLMLQGSVDLLNEVATSKITGEEEIYSHTDLYDFKANVEGAQKIYDLFKPILEKKDKKLSDDIQMNFDKVNQLLDKYKDNNGGYESFEKVSKKDRKAFADAVNALGEPLSKMAVITE
What are the official names of this protein?
Efem/EfeO family lipoprotein.
What is the protein family that this protein belongs to?
Belongs to the EfeM/EfeO family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: VIF_HV196
Sequence: MENRWQVMIVWQVDRMRINTWKSLVKYHMHISKKANRWYYRHHYESRHPKISSEVHIPLGDAELVVTTYWGLLTGERDWHLGQGVSIEWRLKRYRTQVEPDLADQLIHIYYFDCFSESAVRKAILGHRVSPRCECQAGHNKVGSLQYLALTALVAPRRPKPPVPSVKKLVEDRWNKPQKTRGHRGSQTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: NRDR_DESHD
Sequence: MHCPFCGNDETKVLESRQVEEGTAVRRRRECERCARRFTTFEKFEDTPLIVVKKDGRREEFSRGKLKAGILRACEKRPVSIEQIETLVYEIEKGLRNGSEREVQSKAIGEAVMNALVHLDEVAYIRFASVYREFKDVQRFLEELHELVEKKSSR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: YPNP_BACSU
Sequence: MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLLGAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTGLSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALGDSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKLVPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQRLDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFGKYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISFWVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK
What are the official names of this protein?
Probable multidrug resistance protein YpnP.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS10_PSET1
Sequence: MSNQRIRIRLKAFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRFERFTVLTSPHVNKDARDQYEIRTHKRLIDIVEPTDKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: GPI10_KLULA
Sequence: MSNQVPLKRLFKVILVIRCVQALLTRTFFQADEFWQSLEPAHYMAFGYGELTWEWSFGLRSYAFPLIFQIGYTLVKYAAISCELIVQTATDWVLLFVANVIPNSEFGWEMVQEMRSFPEEIRGFIEYQGVIYAPKLIMAVLAAIGEFHVILLAEKLYKLTMDKSDDSKGSDKKHSTVINFTLVATVSNFFNCFFITRSFINSFEMILTSVSLYYWDWTSGEHIESFDFLKSLIIGTFTVLQRPTNAFIWLILGGYMILNLVLSKRWRKLFSLLIKVICASFISISTNLCIDYYFYGYITIPVLKFIKFNCTSSLSKFYGVAPWNFHVFQSLPIVAGYSLPLLIHSFFCSLTKKRFLSPLVNPFLQIKTVVLLNVILYSLIPHKEFRFIYPLQPFFIILSVFDGIWLLQKYGSTATTRTMEFFSQVMWILPVVSMVASMLLSTLHESGTVAVMDYLHSIRNIDSIGFIMPCHSTPWQSHFHRNDVKELWAITCSPPLHLLTDPDANAKLPFYMDESDYLYDNISKFMYQHFPPVFRKSLRSPGKQYTYEWPEYLVIFEDLDSQFMNDYLVDSMYIEETRFFNSLVHWDKRRSGDIIIYHKMP
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 3, GPI mannosyltransferase III, GPI-MT-III, Glycosylphosphatidylinositol-anchor biosynthesis protein 10.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 22 family. PIGB subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: Y030_SULIY
Sequence: MIKEYYGAETFILNKDFAYILVIGTTDVSLIPGLTIAGATPELTHFTPAADAEYVLLGKCKSINTIPVSPTGIPTPALLTRASLSFINPLKIVVNAGSRILPKIPYIDLQGEPGKDIRKQALSMEKVNNIIENSIKLGEELSNEYELIMIGESIPAGTTTAMATLLALGYDAMDKVSSASPDNPKELKRKVVEEALRNLPTDSLQRLAKVSDPVLLGVAGTSLGFKGKILLAGGTQMTAAAAIINEFDKNKLKDITIGTTKWIVEDKFADMLSLAKQVGVKVLASMLDLSISAYEGIRAYEKGYVKEGVGAGGSAIMALVRGVSNNTLVRKIDELYGELVGSNNLHI
What are the official names of this protein?
UPF0284 protein YG5714_0030.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: RRF_BUCAT
Sequence: MINQIDIKTRERMEACIQTFHNNINNIKTGRASPTLLHNIYIEYFGSKTPLRQVSNIIVEDSHTLKINVFDDSITSLIRKSILNSNLDLNPVLQGKDIIIPIPRLTEERRKQLIKVIRGDAESSRIQIRNIRRDANDKVKRLLKDKIISEDNEHTSQSKIQIMTNEYIKKIDCILEKKEKELMKF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNG3_SCHPO
Sequence: MTHELSSTPQIDLLNDILKNSVESNVFSDYQKKQIVTLILKSKISTAIVLLSPKSTAASEWNYLCNLQDLHECVLCVDTILPANLQTIAKRIFSLVLLPPLNDWCKQLRDAFLRFVSQPSICPTDFPLKLFFLSTVGIELLIVNEKIIPQKTQKYLLYELFSSPSSITANEIARLCQEANNRNYLLQSLTSATDARRAFLNNPNYRLLSAIIFQDGPSNLAFVLAKDCVLLARQPETIPVSFERMSSLLLMCLPSHPDFISPEFCHEWTELAERNGLQEEWLNILNTACNFKECRAIIHKECSEFIKDNHTSRVAILISMKLAFQYQLSQVIPTLKLLLQSKVYDSVLLEALRQSSTLGPVKQLIADDSCLLNNLSKLLLDTNISPLDASSIATIIYNMCKFKITKSEHERELNQLRNMAEASKTIDYKEDETAPTERRIQKILEYDILSKLFSAAKHYNSLNGLLAMILVHMANYKLARRKLVQIGALKFLTRQCFIQTQDSNAAFALAKILISVAPHSIFTKAFPSNRAIHPMSKLLSTNSADTEYPILLGKFEVLLALTNLASHDEESRQAIVQECWRELDELIIETNPLIQRATTELINNLSLSPYCLIKFIGDKDSDFENTRLHIVLALSDTEDTPTRLAACGILVQITSVDEGCKKILSLQNDFNYIVRMLTDQDEGIQHRGLVCICNIVYSKDQEIFNKFIKTPKAVETLRTYITKQAALKELQHEALVMIDSRLQGSK
What is the function of this protein?
Essential for actinomyosin ring assembly during cytokinesis.  Has a role, in conjunction with F-actin, in assembling myosin II-containing proteins, such as myo2, at the division site.
What are the official names of this protein?
Ring assembly protein 3.
Protein: CT03_CONTS
Sequence: MRCLPVFIILLLLIPSAASVAQPKTKDDVALASFYDNAKRTLQRHWAKSLCCPEDAWCC
What are the official names of this protein?
Conotoxin Ts-03.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NOLC1_MOUSE
Sequence: MADTGLRRVVPSDLYPLVLRFLRDSQLSEVASKFAKATGATQQDANASSLLDIYSFWLNRSTKAPKVKLQSNGPVTKKAKKETSSSDSSEDSSEDEDKKAQGLPTQKAAAQVKRASVPQHAGKAAAKASESSSSEESSEEEEEDKKKKPVQQKAAKPQAKAVRPPAKKAESSESDSDSDSDSSSEEETPQTQKPKAAVAAKAQTKAEAKPGTPAKAQPKVANGKAAASSSSSSSSDDSEEEKKAAAPPKKTVPKKQVVAKAPVKVAAAPTQKSSSSEDSSSEEEEGQRQPMKKKAGPYSSVPPPSVPLPKKSPGTQAPKKAAAQTQPADSSDDSSDDSDSSSEEEKKPPAKTVVSKTPAKAAPVKKKAESSSDSSDSDSSEDEAPAKPVSTTKSPKPAVTPKPSAAKAVTTPKQPAGSNQKPQSRKADSSSSEEESSSSEEEEASKKSATTPKAKVTAKAAPAKQAPQAAGDSSSDSDSSSSEEEEKTPKPPAKKKAAGGAVSTPAPGKKAEAKSSSSSSSSSSEDSSEEEKKKKPKATTPKIQASKANGTPASLNGKAAKESEEEEEEEETEEKKKAAGTKPGSGKKRKQNETADEATTPQAKKVKLETPNTFPKRKKGERRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSVKFDSE
What is the function of this protein?
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (By similarity).  Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (By similarity).  Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:11424213).  It has intrinsic GTPase and ATPase activities (By similarity).
What are the official names of this protein?
Nucleolar and coiled-body phosphoprotein 1, 140 kDa nucleolar phosphoprotein, Nopp140.
What is the protein family that this protein belongs to?
Belongs to the NOLC1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase.
Protein: TTC34_MOUSE
Sequence: MLLRSPSYAGKAAQAQEGDAYGVYQLATLLIGMDAEDETSCLLAADALYRLGRLDDAHKSLLVALSQRPQAAPVLVRLALLQLRRGFCYDANQLVKKVAQSGDTACLQHMLDIFHHEDLQLLQDHCHTRALSILRARPGGSDSEAHTREAIAYLSLAIFAAGSGGSESLLVRARCYGLLGQKKTAMFDFNAILREEPGNVKALCGRALVHLALDQLQEAVDDMVSALKLDPGTVIPEILSLKTEVQLPLTQGLYTRCRVLLNQCLHTGVPLREEDTQGLLAMGKALIRINATQPSWRLLLTDILTGLGKYQEAGTHLQEALHLTPSSEAAQARQGLLQLKKGDVSAAVHGLQCLAERDTQDLGFLLCLLDSPERQSLVQTAAKEASNILDLGNPGQALSYCSLAILAGGNNPYHLRLRVACLTQLQEYDRALRDLDRVLQHPAEDSDLPRQSEDFCTRGRLLLSLGDKDGAAGAFTQALALAPAQAQNSLLEQPGQAMTASVFLIHGQRCLEEEHFEEAWTAVQNGLLVDPSHSGLKKLKLRTRKVATSGCRLH
What are the official names of this protein?
Tetratricopeptide repeat protein 34, TPR repeat protein 34.
Protein: CENL3_HUMAN
Sequence: MGRVRNRATAQRRRRKRPGDPPAACAAIAVMGASRAQCPRVQVGVGSHAAAKRWLGKLRRKRRWRRAREAGSRDPLPSAPLPDPPAPAESPKELDLGAQRERWETFRKLWGLSCEGAAKVLLDTFEYPGLVHHTGGCHCGAVRFAVWAPADLRVVDCSCRLCRKKQHRHFLVPASRFTLLQGAESIVTYRSNTHPALHSFCSRCGVQSFHAAVSDPRVYGVAPHCLDEGTVRSVVIEEVGGGDPGEEAAEEHKAIHKTSSQSAPACPREQEQ
What are the official names of this protein?
Centromere protein V-like protein 3, Centromere protein V pseudogene 3.
What is the protein family that this protein belongs to?
Belongs to the Gfa family.
Protein: DEF1_TRIKH
Sequence: RTCQSQSHKFKGACFSDTNCDSVCRTENFPRGQCNQHHVERKCYCERDC
What is the function of this protein?
Has weak antifungal activity against F. graminearum and F. verticillioides below 30 ug/ml, but not against A. consortiale B. cinerea, H. sativum, F. culmorum, C. graminicola and D. maydis.
What are the official names of this protein?
Defensin Tk-AMP-D1.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
Protein: OBG_PSEA7
Sequence: MKFVDEVSIHVKAGDGGNGLMSFRREKFIEKGGPNGGDGGDGGSIYLEADVNLNTLVDYRYTRRFDAQRGENGGSKDCTGAKGDDLVLPVPVGTTVIDANTQEIIGDLTEPGQRLMVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGEARDLKLELKVLADVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRILLHLVDMAPLDESDPADAAEVIVRELGRFSPALTERERWLVLNKMDQILDPAERDARKQAVIERLGWEGPVYVISALERDGTEALSQDIMRYLDERTLRLEEDPQYAEELAELDQRIEDEARARLQALDDARALRRSGLKNAGAADDDDFDDEEDDGDGPEIFYVP
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSTP_ONCVO
Sequence: MSYKLTYFSIRGLAEPIRLFLVDQDIKFIDDRIAKDDFSSIKSQFQFGQLPCLYDGDQQIVQSGAILRHLARKYNLNGENEMETTYIDMFCEGVRDLHVKYTRMIYMAYETEKDPYIKSILPGELAKFEKLLATRGNGRNLILGDKISYADYALFEELDVHQILDPHCLDKFPLLKAFHQRMKDRPKLKEYCEKRDAAKVPVNGNGKQ
What is the function of this protein?
Appears to play a central role in the parasite detoxification system.
What are the official names of this protein?
Glutathione S-transferase 2, GST class-pi.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Pi family.
Protein: AT1B4_CHICK
Sequence: MEPGMEMNTASEGGTRRGPENKHEEKVQDPNRGEAETKAEMGNKTWADLAGEMKTFLWNPEERTCMGRTAKSWGLILLFYFIFYTCLAGMFAFCMYVMLLTLSPYTPTYRDRVSPPGVMIRPYLNGFTIAFNVSKPSTWQPYVDSMHQFLAAYDDKVQEEKNIECISGQYFIQGGNDSEEKKACQFKRSLLQNCSGIEDPTFGFSKGQPCILLKMNRIIGYRPGAGVPVNVDCKVQKGNESDLRSVDFYPGNGTFDLMYYPYYGKLTHVNYTSPLVAMHFTDVKRNSLVHIQCKLNGKGIINDVNSDRFLGRIIFTLSIGK
What is the function of this protein?
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
What are the official names of this protein?
Protein ATP1B4, X,K-ATPase subunit beta-m, X/potassium-transporting ATPase subunit beta-m.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: FOLD1_FRACC
Sequence: MRMLDGRSMAAEIGRYVVDEAERLAAAGVTPTLAVVLPTADPAAYSYAEIIERTAGKVGVHCVLHEPKGEPAAILDTIDTVAADPTVHGIIVQTPLPGGLTSREVGEHIPTAKDVDGMNPSSLGRLALGLPSFAPATAAAVVEILTRARIPMSGARVCVIGRGPVVGKPVSLLLLAEDATVTICHSRTKGLVSIAHEADIIVSATGHPRLVGAGFVRPGAAVIDVGTVVTETGQVGDVDAAAVSSVAGALTPVPGGVGPVTTMLLLRNTIRAARAA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 1.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: B2MG_PAROL
Sequence: MGLLICSLLLGLLCCSMAKDTPPKVEVYTREPEEFGKPNSFICHVSGFYPPQINITLLKDGKEIPNTQQTDLAFEANWYYYLTKHVSFTPKEDDEFICRVTHMGKSKDHFLMIGL
What is the function of this protein?
Component of the class I major histocompatibility complex (MHC).  Involved in the presentation of peptide antigens to the immune system (By similarity).
What are the official names of this protein?
Beta-2-microglobulin.
What is the protein family that this protein belongs to?
Belongs to the beta-2-microglobulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEUC_PICTO
Sequence: MKTAVEKIFSDKSGNDARAGDYVIANLDYVMVNDITGPIAIDAFNELGYKPLSDRIVVIPDHFVPPKDINSAIQYKKVKDFALKHNTHFYDLGRGGVCHQVMMEKGFAAPGRLIAGADSHTNTYGALSCVSVGIGSTEAGVIFGTGRMWFKVPETDLIRINGRPKKGVYGKDIILNVLSRIGNGGSAYKCMEFTGSTIDYLDINERMTMANMTTEAGAKCSFFNADEKTLDYIRNKTNDYKIYKDDENAEYSRIIDIDASEIEPSVAIPNSPDNVRPVSKVSERIDQAYIGSCTNGRIEDIRRAALILKDKKIDKNVRLMVVPASQEVYNQALKEGLVDIITDAGGYFAGTTCGACLGGYMGVLGPGETCISTTNRNFIGRMGDRTSRVYLANPEVVAASAIMGRIASPEEIQ
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.