PharMolix/UniProtQA huggingface dataset:
Protein: AROA_XANAC
Sequence: MSSSTHHWIARRGTALQGSLAIPGDKSVSHRAVMFAALADGVSQIDGFLEGEDTRSTAAIFAKLGVRIETPSASQRIVHGVGVDGLQPPTEVLDCGNAGTGMRLLAGLLAAQRFDSVLVGDASLSKRPMRRVTGPLAQMGARIETQDDGTPPLHVRGGQALHGIDFVSPVASAQVKSAVLLAGLYAQGETSVTEPHPTRDYTERMLSAFGVEIDFSPGKARLRGGQRLRATDIAVPADFSSAAFFIVAASVVPGSEVVLRAVGLNPRRTGLLAALRLMGADIGEENHAEHGGEPVADLHVRYAPLRGAQIPEALVPDMIDEFPALFVAAAAASGQTVVTGAAELRVKESDRLAAMATGLRTLGIQVDETPDGATIHGGSIGSGVIESHGDHRIAMAFAIAGQLSMGQVQVNDVANVATSFPGFDTLAQDVGFGLETAGHR
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1596_LACLM
Sequence: MDDMLIVTTNEVAGYRIVEVYGEVFGLTTRSRNLFSSAGQQMKTVVGGEINGYTKLQHDTRETSIGRMKEEAKAKGANAIVAMRFDSSTFQNIDSVAAYGTAVKIEKI
What are the official names of this protein?
UPF0145 protein llmg_1596.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: MIAA_PSYA2
Sequence: MTIKGNRMRLSSDSLSHHLSPSLADNSVVCLMAPTASGKTNLAYELYDSGRYELISVDSALVYRDMTVGTAKPNAAELARYPHHLVDIIDPMQSYSVAEFVSDVARLIDSCHQNGKIPLLVGGTMMYYMALLDGLSPVPVSDDSVRARVEQWRQDEGISALYDYLGKVDAISHERLNATDTQRITRAVEVYLQTNIPISDWQRQPKQALAHNPNQQWHALAVMPDRPWLHTRIEQRLDIMWREGLVEEVISLLERYPLTPSLPSMRCVGYRQVLEYLVQINHPVFEQSHLDKAQFYDAFAQSNLSSVESNEQDATTQSGMTQTHLSVATDQTEALACQQMQNKALYATRQLAKRQYTWLRKVMQLSDTAAEQATVSSAAPSTSIIGFDDMTASQNDKLILHSFITMEQARAYLC
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: AMPA_CAMJE
Sequence: MKFELNDKKLDAIKADFELVFIQDKNLKIFNKEKDFFKLNNYKGEGALLDLNNKKLYLELKSLAYEDIRLSLCTAYKTLEKLNIKSVKLPSIIGDCVVRSFASLVEGVLFGAYKFDKYKSEKKTSTLEKFIISNEELNGKKFNKDEAKIGLERGEILANATNFTKNIVNEIPEIYTPLKMAEDAQNLAKENKNIICKIYDEKFLAKEKMNAFLAVNHASVHPPRLIHLSYKAKNAKKRVVFVGKGLTYDSGGLSLKPADFMLTMKADKSGAAAAMGIIKAVAELALDLEVHCILGATENMIGGNAYKPDDVLISREGVSIEVRNTDAEGRLVLADCLSFAQDLKPDLLIDMATLTGACVVGLGEFTSAIMGNNEELQNDFYLSSKKSGEYTTILHFNPHLRELIKSNIADVSNTASSRYGGAITAGLFLDKFIRKEYKDKWLHLDIAGPAYTEKSWGYSSFGAGGAGVRMCVNYLIQILRKAK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SVH11_CAEEL
Sequence: MRLFHFLKFLTINNFSRYCLKIVKVHIIWITIICIIYFNWRFKKLDFMAIPYPPAVIKFNTSAKYLSSNLASSSQLGNNIFEIASLYGLSKHLNRTPLFFIENGYHKKMLDNLRKTMPRLMEKFRILNGSVPRSISETKFQRACCLHKSPWSLEKNRDEYLHLSGKYYQSWKYFPNMRNELIEFLNPTSIQIFGNLPISDDQNHVTCVHSRRGDFVEYLFYASDPKFMKNAVTFLNENEKVGSRNRKIVLFGDDLNFLETYFSDAVLSTDVGKNAEYYISQNPPIDDFLYSKNNCDVVLITAPRSTFGWWIGYFSKGNKVYYLDIKYTGDHIFESGGLIASDFYPSHWTPLKFASANSFTVVRS
What is the function of this protein?
Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (By similarity).  Required for axon regeneration after injury (PubMed:31371405).
What are the official names of this protein?
Putative galactoside 2-alpha-L-fucosyltransferase svh-11, Suppressor of vhp-1 deletion lethality protein svh-11.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 11 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: HSLU_BRUA4
Sequence: MSNFSPREIVSELDRFIIGQNDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFVKVEATKFTEVGYVGRDVEQIVRDLVEVAITLVREKRRDDVKAKAHLNAEERVLDALVGKTASPATRDSFRKKLRNGEMDDKEIEIEVADTGSGPSFEIPGMPGANIGVMNLSDMLGKAMGGRTKTRKTTVKDSYPILINDESDKLLDQDQIVQEALRVTEDEGIVFIDEIDKIASREGGMGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHVLFIASGAFHVSKPSDLLPELQGRLPIRVELNALTREDFRRILTETEASLIKQYIALMETEEVKLEITDDAIDALADIAVDLNATVENIGARRLQTVMERVLDEISYTAPDKTGATFVIDAAYVKDKIGSLAKNTDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_GEOTN
Sequence: MAIVLGAKERKDKKHSTLRRIRSQGGIPAVLYGKKVDNKMISISAADLEKALREGGRHSLVTLKVDGEDYSVLLREVQRDPLRGELLHADFQAVDMSAEVDVDVEVRLVGEAPGVKDGGVLQQNLHELSIRVLPANIPPAIEVDISGLQVGDVITVGDVQTGGTFEINHEPSEVIATILPPQQEEEIHSGEQQEPGQPEAEEGRETTPEG
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: P3URF_HUMAN
Sequence: MGPSRLVRGPRPQGMRSPYRRPGMGWPRPRFPRMFKCSRRRYQQGLRGRTASSAAINPATRAMGINNTHTDTTIVWIFPPQVLRHLRQPGIFLIL
What are the official names of this protein?
PIK3R3 upstream open reading frame protein.
Protein: TRMB_METFK
Sequence: MAQEMTGNENIGKEELARRPIRSFVLRQGRLTHAQQRALDELMPVFGVPYAPVILDLDSLFGREGSPKVLEIGFGMGDSTAKIAQSQPECDFIGVEVHTPGVGSLLKQIGELQLNNLRIIQHDAVEVLQHMIADASLDGVHIFFPDPWHKKRHHKRRLIQAAFVKLLCSKMKAGAYLHVATDWQEYAEWVLDILQQEPLLENTAQSYAPKPDYRPLTKFENRGIKLGHGVWDIIFRRK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: EXOS1_MOUSE
Sequence: MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKTSENGAVPVVSVMRETESQLLPDVGAVVTCKVSSINSRFAKVHILYVGSTPLKNAFRGTIRKEDIRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGVQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  It seems to be involved in degradation of histone mRNA.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8 (By similarity).
What are the official names of this protein?
Exosome complex component CSL4, Exosome component 1.
What is the protein family that this protein belongs to?
Belongs to the CSL4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus. Cytoplasm.
Protein: Y8812_DICDI
Sequence: MKTFRDFKKKIKNNNNNKNNKNNNINNNNSNNNKNNKNNNNNNSNNIYTPSISIIDNYDTLCSTPQNLKSNLKKNLNINNQEFITSNILEIDWNTIIDIEIIDFGNSIVCLLVTLSSDNLHFNQILIKSTPTIAQECYASVLQNILKLPILDLRLLEKNNEFLEMSSNLLDFSKDDQFLNDFIKSEFEKTFFLIMEFRQNGKKFNELNHKEYFSGYKGQEKFKQLGKIIAFDIFCNNFCKTNIAGDDSSIYFSNIICYETPNKNGWYFSLINSNISCLNNSLFTIGYRYHMNSLKLLLFSIFQNPSTESFQIRMMREHLLKKLNIKLPKSSAVYIQKGIAKGIKSIVNYINYPLLENTKDKVKNIVSCDNYNIWKKGIDSIHCPFLLDVLNEIEIEISNRREKVYFVKI
What are the official names of this protein?
Putative actin-fragmin kinase DDB_G0268812.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AFK Ser/Thr protein kinase family.
Protein: PCY2_DICDI
Sequence: MSTTTNKKPIRVYVDGCFDLMHFGHANALRQARELGDILVVGVHTDEEIAKNKGPPVMNEQERYKAVRACKWADEVAEGAPYTLTEEYLDSLNCDFCVHGEDISVGADGKDVYEGIKKSGKFRFIKRTEGVSTTELVGRMLLCTKDHLQNVSGEQTSPLGGVNPNVLHKQSPYTSLSHFLPTTRKIVQFSEGRSPKPNDKIIYMDGGFDLFHVGHTEALKQARALGDYLIVGVHDDRVVHEQKGSNFPIMNLHERVLSVLSCRYVDEVVIGAPFSVTKDMIDSLHINVVVHGDDQVVLGPEGGVDPYKLPRELGIYKEVKHTEGLTATEIVKRIIDNRLQYEARNRKKEAKEINFIEQSN
What is the function of this protein?
Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway.
What are the official names of this protein?
Ethanolamine-phosphate cytidylyltransferase, CTP:phosphoethanolamine cytidylyltransferase, Phosphorylethanolamine transferase.
What is the protein family that this protein belongs to?
Belongs to the cytidylyltransferase family.
Protein: NU1M_YARLI
Sequence: MIINIVEILIFLVCVLFSVAYLTVAERKTLAYMQRRLGPNFVGYYGLLQAFADAVKLLLKEIVLPKESNYIILVISPLITLITALIGWVVIPLGPGITLGELNLGILFSLAIGSLGVFGSLLSGWSSNSKYSLLGSIRSTAQLISYELILTSIFIIIIMFVSSLNITTIIETQRVVWYCIPLLPLLLIFFIASVAETARPPFDLTESESELVAGYFTEYSGSPFVFFFLAEYSNIILISAFNGYLLLGGYLSFNYSYLFNILFNDYSYVSFLFEGLINSSAYAIKLVFLMFSFIWVRAAFPRFTYDNLINFCWIILLPLLFGIFLIIPSTLYIFDSFPTLI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YIDD_SALPC
Sequence: MAPPLSPGSRVLIALIRVYQRLISPLLGPHCRFTPTCSSYGIEALRRFGVIKGSWLTVKRVLKCHPLHPGGDDPVPPGPFDTREH
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MPRB_MYCLE
Sequence: MVRFAWRRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAVYVVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKAVIRGELFMSQRTASDQRILAIHLPNDSSLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPIDMSEVLYRSLERVRRRRNDIHFDVQAIGWQIYGDAAGLSRAVLNLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPGIPPQERRLVFERFYRSTTARSLPGSGLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQSARAR
What is the function of this protein?
Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host.  In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity).
What are the official names of this protein?
Signal transduction histidine-protein kinase/phosphatase MprB, Mycobacterial persistence regulator B.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BLN03_BRELC
Sequence: MRPRKYIVVVLLSIAYTMCLAVGYPSDGTDDSTKSLKSGNRIRSHTPDIGTEERTLTWLKSMLRPSSSSAKVTKEIPEVVKSASDFKVRQTLSAITRKLGLHSQRLKRFASWLRKTGERLTRKKVYYAGYIAIVDSSSSQLKRLSVTYGSAFLFVIGFIVLLAFAMTAV
What is the function of this protein?
Secreted effector that inhibits stress-induced relocalization of the endoplasmic reticulum tail-anchored transcription factors to the nucleus, thus affecting stress responses.
What are the official names of this protein?
Secreted RxLR effector protein BLN03.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host membrane; Single-pass type I membrane protein.
Protein: PHNC_POLSJ
Sequence: MNIKLDKVSARHPAAKRDAAAALRGVSLEVSAGEQIAVIGPSGAGKTTLLHVLGCALPPSSGSLQLNARDPWRLPRSKLQLLRGELFLAPQVPPLPPRQRVVTSVLAGRLPHIGLWQSLRSLFYPTAIAQADAALARFDLSDKLFARVDRLSGGERQRVGLARALVTEASLLLVDEPLSALDPTRGQQAIASLTQAARERGATLVSTLHHVEMALQNFPRIIGLRDGELAFDLPAAQVTPERLQALYAQHLHELTGPAHEAFDLPAAATPPAVMHCR
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YWBC_BACSU
Sequence: MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELAFLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEITTLPNGYRYFYIEGPDGEWIEFFQR
What are the official names of this protein?
Uncharacterized protein YwbC.
What is the protein family that this protein belongs to?
Belongs to the glyoxalase I family.
Protein: RN122_MOUSE
Sequence: MHPFQWCNGCFCGLGLVSTNKSCSMPPISFQDLPLNIYMVIFGTGIFVFMLSLIFCCYFISKLRNQAQSERYGYKEVVLKGDAKKLQLYGQTCAVCLEDFKGKDELGVLPCQHAFHRKCLVKWLEVRCVCPMCNKPIAGPTETSQSIGILLDELV
What is the function of this protein?
May induce necrosis and apoptosis.  May play a role in cell viability (By similarity).
What are the official names of this protein?
RING finger protein 122.
What are the subcellular locations of this protein?
Golgi apparatus. Endoplasmic reticulum. Membrane; Single-pass membrane protein.
Protein: IHFA_ECO57
Sequence: MALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPKDE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RBSA_LACP3
Sequence: MKIEMKKITKSFGANRVLEGVDFTVESGEVHALMGENGAGKSTLMNILTGLYQANSGEILVDGQPTTYSGPMEAEQHGISFIHQEMNNFLEMSVVDNMFLNKELRTKFGLMDNKAMREQAAHYLSLLGAKLDVEQPIGNLSVGRQQMVEIAKSLMTDAKIIIMDEPTAALTETEIDQLFGVVRRLKEKGVGFIYISHRMEEIFEIADKVTVMRDGLSITEYATKDVTMKQLVKDMVGREIDDFYPDRTPDHGPVAMEVKGLTENGVFKDVSFTVHQGEILGFSGLMGAGRTEIMRAIFGIDKYQSGEILLDGKPVKIRDPQDAIRHNIGFLTENRKDEGLILEDSLHDNIVLPSIDGFVKHGLVDDKATDEFVRMLMKRLTVKAMGPDVSAGSLSGGNQQKVVLAKWIGSGSKVLILDEPTRGVDVGAKREIYDLMNELTDRHVAIIMISSDLPEVLGMSDRIAVVYEGKITGILDGKTATQESIMTLATGGVEEHAGAI
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GLYA_SHEWM
Sequence: MLKKDMNIADFDPQLFQAIQDETRRQEEHIELIASENYTSPRVLEAQGSQLTNKYAEGYPGKRYYGGCEHVDIAEELAISRAKELFGATYANVQPHSGSQANAAVFMALLEGGDTVLGMSLAHGGHLTHGSHVSFSGKLYNSVQYGIDETTGKIDYAEVERLAVEHKPKMIIAGFSAYSGIIDWGKFREIADKVGAYLFVDMAHVAGLIAAGIYPNPLPHAHVVTTTTHKTLAGPRGGLILSAIDDEAIYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEALEPEFTAYQEQVVVNAQAMAKTFIERGYDVVSGGTDNHLFLLDLISKDITGKDADAALGLANITVNKNSVPNDPRSPFVTSGLRIGSPAITRRGFKEAQAVELTNWMCDVLDDITNEGTIERVKNQVLELCAKFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLS_LISMF
Sequence: MGLLAYLLVILLILNVFFAAVTVFLERRDTSATWAWLLVLTFVPIFGFIIYLIFGRKLSGKKIFDWKGQEKIGIQESTANQIEMIRQKEFPFSDPNVKKHRDLIYLLLVNDGAILTQDNEVELFVDGHEKFDALIADIEKAKDHIHLIYYIFHSDELGNRLMRVLERKAAEGLNVKIIYDAMGSRTTKKSFFRTFQKNGGLVRPFFPSKLPLINFRLNYRNHRKLAIIDGDVGYIGGFNIGDEYLGASKKFGYWRDTHLRVHGKAVYAMQTRFIMDWNSASSTHKIDYKARYFPTFHGKGHTSMQIVSSGPDSEWQQIKNGYIKMINAAKKTIYLQSPYFIPDASLLEAIKIAALSGVDVRVMIPNKPDHAFVYRATTNYAGELMETGAKIFIYDNGFIHAKTLVVDGEIASVGTANMDFRSFRLNFEVNAFIYEKQMVQKLEDAFLEDILKSYQLTPELYAKRSLWIKFKEAVSRLLSPIL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEU1_BURP1
Sequence: MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKQLERMKVDVIEAGFAASSNGDFDAIQTIASQVKDSTICSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNIEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFARFKDLADRKAEIFDEDIIAIVTEEESALAQEHEHYKFVSLAQRSETGERPQAKVVFAVDGDEVAGEASGNGPVDATFNAIETEVGSGAELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLYSNADKLNPQRA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: GSA_ACTP7
Sequence: MSKSEQLFEKAQKVIPGGVNSPVRAFKGVGGTPVFIQKAEGAYITDSDGKKYIDYVGSWGPMVLGHNHPAIIDAVLKAVPNGLSFGAPTESEITLAELVTKLVPSIELVRMVSSGTEATMSAIRLARGYTGRDKIIKFEGCYHGHSDSLLVKAGSGALTLGQPSGPGVPADFAKHTLTCTYNDLDSVKTAFEQYPNEIACLIVEPVAGNMNCIPPKNDFLKGLRALCDQYGAVFIIDEVMTGFRVALGGAQAYYDVKPDLTTLGKIIGGGMPVGAFGGKKEIMEYIAPTGPVYQAGTLSGNPIAMAAGLACLTELSKAGNEEKLAAQTKTLAEGFKALADKHNVPFTAQYVGGMFGLFFTEQAEITNFQEVMKCDAAKFNRFFHLMLEQGVYLAPSAFEAGFMSLAHSDEDIQATLVAADKAFAQL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF1G_RABIT
Sequence: MAAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNRTPEFLRKFPAGKVPAFEGDDGFCVFESNAIAYYVSNEELRGSTPEAAAQVVQWVSFADSDIVPPASTWVFPTLGIMHHNKQATENAKEEVKRILGLLDAHLKTRTFLVGERVTLADITVVCTLLWLYKQVLEPSFRQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAESQPKKDTPRKEKGSREEKQKPQAERKEEKKAAAPAPEEEMDECEQALAAEPKAKDPFAHLPKSTFVLDEFKRKYSNEDTLSVALPYFWEHFDKDGWSLWYAEYRFPEELTQTFMSCNLITGMFQRLDKLRKNAFASVILFGTNNSSSISGIWVFRGQELAFPLSPDWQVDYESYTWRKLDPSSEETQTLVREYFAWEGAFQHVGKAFNQGKVFK
What is the function of this protein?
Probably plays a role in anchoring the complex to other cellular components.
What are the official names of this protein?
Elongation factor 1-gamma, EF-1-gamma, eEF-1B gamma.
Protein: CPIN1_XENLA
Sequence: MDDLANLVFPGQQVAVTWDGSSSTEALKEFVSKLQEVVAPRGKVSVENIERLLLSAHADSSFDAILLGMVQGTQCIHSSEVLAEVARILKPGGALIIQEPVAAGAGAQLRTPEHLSSVLKLSGLTEVTQLLQEPLNPEQKQGVVELLGYNGNDVSTIRIRAKKPNYEVGSSRQLSLPKRKTAEKPSVDPAAAKLWTLSASDMNDDDVDILDSDELLDQEDLKKPAPSSLLASGCGEGSEKKRKACKNCTCGLAEELEAEKTPSTVPKAAPSACGNCYLGDAFRCASCPYLGMPAFKPGEKVLLNPTKLQDA
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2.  Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1.  NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.  Has anti-apoptotic effects in the cell.  Involved in negative control of cell death upon cytokine withdrawal.  Promotes development of hematopoietic cells.
What are the official names of this protein?
Anamorsin, Cytokine-induced apoptosis inhibitor 1, Fe-S cluster assembly protein DRE2 homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion intermembrane space.