PharMolix/UniProtQA huggingface dataset:
Protein: MYSM1_BRAFL
Sequence: MADDEEIDIEGDDDAPLLFDHKDDALALPDLPGYEPNWMFDHGQEIYGRSWTSISQFVQTRTPLQVKNYARHFFKTKVVQKVEEGEDEDVDIEGEESGEEAVMELRSTCGLNPAQPAVVTSDDTSTGENVMEETEAVTEDHPSLDNLVQDDREMPQQETTGDGEQYPMDEHFLPVFPWQPDDTQNRVIVERIEGSVGLGSVRGDKDVRPVPGVEQNTYGPHTDMFQVQNTLLAFEKQVGADRIFEGPSXSKNEATDTQTEVSETKTEVIERQTESQVDATHMHTYGDGLMGSIERLTESVSSSELKEDLKTGIEYVEKDDATDSSSTAKGYDNYTLDHPEDRSKPDSVVSEKWSCEEAMSSHTDGRTFSDSDSGKETYDLPRYNTTIFQGHSEDETSDAGQAEEETFFTFKKPTEEVVLDRSVITEEEKEVHKEFFDGRQTKTPERYLKIRNHLLDCWERTKPEYLRKTVARAGLRNCGDVNCIGRIHGYLERIGAINFGCEEANRGEFPVAKVGVKRNPQGHGEQLALQAARLESMHVTSDELEKQDGGVSQIRPNRSRAARTNLNSFSYDPFKLVPCKRFSEESPAPFSVKIHATALVTIDMHAHISTAEVIGLLGGVFHRDPGALEVASAEPCNSLSTGMQCEMDPVSQTQASEALSQAGYSVVGWYHSHPTFAPNPSVRDIETQTKFQEWFAQGGSPFIGIIVNPYSSTRISPLSRVTCLTISSEWNPPAIQRVKLLSRYAGHTDTTYMDKMLYSLSGHLCRGNADSDEDGNSESLTLLTDIRDIFANSWTSSLGTTPRSSIASL
What is the function of this protein?
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator.  Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes.  Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome.  Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
What are the official names of this protein?
Histone H2A deubiquitinase MYSM1, 2A-DUB, Myb-like, SWIRM and MPN domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. MYSM1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YM047_YEAST
Sequence: MVFVTIIIIINISYNIYNIYTINENRFTFNAFLQSKKASFTFICIYVCISGGNMPLWAYILFRTFLHPSSSSNSVLCFRRHNQDYHNRIFFAFCCHHIWSLLPHHLSIFPIRRQFYLNSRQ
What are the official names of this protein?
Putative uncharacterized membrane protein YML047W-A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SPEE_HUMAN
Sequence: MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS
What is the function of this protein?
Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM).  Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane.  Has extremely low activity towards spermidine.
What are the official names of this protein?
Spermidine synthase, SPDSY, Putrescine aminopropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
Protein: ATC1_DUNBI
Sequence: MVSHASSGRPSSRDTGMVYLGLGMQDAYSSEVQEVAAFYHVDLDRGLSDRDVQQARIKYGRNQMEAEQSTPLWKLILKQFDDLLVKILLGAAIVDFIIAISEGESIQSGLIEPMVILLILVANATVGVVTERNAEKAIEQLKSYEADDATVLRNGQLQLIPSADIVPGDIVELAVGNKVPADTRVSHIYTTSLKIDQSLLTGESQAVEKHTEVVHNEQAVYQDKLNMLFSGTLVVAGRARGIVVGTGSNTAIGKIRDAMGVEEDVVTPLKAKLDEFGALLSKVIAGICVLVWVVNINRFNDPALGGWFQGAIHYFKIAVALAVAAIPEGLPAVVTTCLALGTRKMARHNAIVRTLPSVETLGCTTVICSDKTGTLTTNQMSVIKVAAVQSSSSQLAEFDVTGTTFSPEGMVLGPGGVVLRQPADTPCLAHAAQCAALCNDSQVFVAQKTGTLQRIGESTEIALRVFAEKIGLPSSIRPDRPISRSQFGTNNFWQEDVERLALLEFSRDRKMMSVLVKGSDRQHNIWSKGAPEFVLRKCSHVLANNGEGAVPLTDNMRQAILSDMQAFGSRQALRCLALAFKSVPTTTTKLDYSDESGLTFIGLLGMHDPPRPECRSALSTCHNAGIKVIMVTGDNKGTAEAVARQVGALSPSTALAGSDDEDNLGISYTGREFEEMGALGQAAATRNLVVLSRVEPMHKLRLVELLKAQGHVVAMTGDGVNDAPALLRADIGIAMGSGTAVAKHAADMVLGDDNFATIVFAVAEGRVIFNNTKQFIRYMISSNIGEVVAIFLAALLGLPEVLTPVQLLWVNLVTDGLPATALGFNRADKDMMARGPRRVDDPIVNGWLFLRYLIIGMYVGIVTVYGFIWWYISFPEGGNMTWSQLTHFQACASQPGGAKDCEVFHSKHPTTISMSVLVVVEMFNALNNLSEDSSLLRIPPWDNKWLVGAIATSMALHFGILYTGASAMFGVTGLSFAEWTMVIKLSAPVILVDEIMKAWSRRRQRHPASSRGGPVSLMEIQVPLTSSSRDEAALKLK
What is the function of this protein?
Could possibly be a calcium ATPase.
What are the official names of this protein?
Cation-transporting ATPase CA1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: POTC_HAEIN
Sequence: MSRFFLRNAFMFVVYAYLYIPIIILVTNSFNKDRYGLSWKGFSWNWYERLFNNDTLIQAAIHSVTIAFFAATLATIVGGLTAIALYRYRFRGKQAVSGMLFIVMMSPDIVMAVSLLALFMVVGISLGFWSLLLAHVTFCLPYVTVTIFSRLNGFDSRMLEAAKDLGASEVTILRKIILPLALPAVVSGWLLSFTISLDDVVVSSFVSGVSYEILPLRIFSLVKTGVTPEVNALATIMIVLSLALVVLSQLITRKNNH
What is the function of this protein?
Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine.
What are the official names of this protein?
Spermidine/putrescine transport system permease protein PotC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VIF_HV1ND
Sequence: MENRWQVMIVWQVDRMRINTWKSLVKYHMYVSKKANRWFYRHHYDSHHPKISSEVHIPLGEARLVVTTYWGLHTGEKEWHLGQGVSIEWRKRRYSTQVDPGLADQLIHMYYFDCFAESAIRKAILGHIVSPSCEYQAGHNKVGSLQYLALAALIAPKKIKPPLPSVRKLTEDRWNKPQKTKGRRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: HEMA_I01A2
Sequence: SLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKASPANDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSNHEASSGVSSACPYLGKSSFFRNVVWLIKKNNAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLTTGLRNTPQRERRRKKRGLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNECMESVKNGTYDYPQYSQKAGLNREEISGVKLESMGTYQILSIYSTVASSLALAIMVAGLSLWMCSN
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: Y115_AFV1Y
Sequence: MGKEKVEEKKENKSGVKEKIQNWIADAKKRGTWQTLLLKQIGNTRLNVAVTPDGSALLKIFINRPQNGIIFSLNELEDIKKAIEIAESIKSELESIPEFKNAKVSLKTQKGVLDE
What are the official names of this protein?
Uncharacterized protein ORF115.
Protein: RR11_FAGEA
Sequence: MAKPIPRIGSQRNRRINSRKNARKMPKGVIYVQAGFNNTIVTVTDVRGRVVSWASAGTCGFKGAKRGTPFAAQTAAGNAIRKVVDQGMQRAEVMIKGPGLGRDAALRAIRRSGILLSFVRDVTPMPHNGCRPPKKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NDUF6_DICDI
Sequence: MIRNSGRILFNSLKNSNVKLINRNVIINSNIRLFSTSTNNTIKESVEKKAETISNKDNIASPSSKSIDVSDLAGNADYNFVFERIKTCDKENYINSLLISDPIARRVAYAIRAFNIETVANDHSPKSEKISRLRLSFWKDAINNIYNGKVYDQPLTRVLAQVIKEKKLTKTWFIKILNRREKDNQQVQIKDMEELEQYADDIHSSLMLLTLEGLGVKGNHDVEHCASHLGKAIGIMVLIRGTVYHLASRKTYIPVSLTTKYGINVESLYRGDPQIEKLQNAIYEMASCAKLHLDKAKQFRGKIPHPATEAFLSVSVVEDFLERLRKADFNIFEFPNTQQHPLLLIKLYKNKFFKQF
What is the function of this protein?
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages.
What are the official names of this protein?
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog.
What is the protein family that this protein belongs to?
Belongs to the NDUFAF6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: MURC_ANOFW
Sequence: MTIYHFVGIKGTGMSALAQVLHDMKCVVQGSDYDKRFFTQEALEARGIPIFPFSAQNIRENMVVIAGNAFPDTHEEIVAARELGVPVIRYHQFLGDFLQKFTSIAVTGAHGKTSTTGLLAHVMQGAKPTSYLIGDGSGKGREGSEYFVFEACEYRRHFLAYSPDYAIMTNIDFDHPDYFANIEDVFSAFQQMAWQVKKGIIACGDDEYLQKIQAKVPVVFYGFGEDNDFQARNIVKTPEGTSFDVFVRHTFFASFHIPRYGDHNVLNALAVIALCHYEGIDVNIIQERLKTFPGVKRRFHEKMLGSQVLIDDYAHHPTEIRATIEAARQKYPERQIVAIFQPHTYTRTQTFLDEFAESLSLADAVYLCDIFSSAREHQGKLSIEDLRAKIEGAKLLDEEQVDVLKQHDNAVLIFMGAGDIQKFQEKYEQSVHV
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI45_MOUSE
Sequence: MSEIRKPLLGFVHKLQDANASGSSGKTHCPTCLRLFKVPRLLPCLHTVCTTCLEKLDPFSVVDIRGGDSDTSSEGSVFQDPELCSLQPQIGILCPVCDAQVDLPLGGVKALTVDHLAMNDVLLENLRGEGQGLVCDLCSDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSQVGKPILCPSHPAEELRLFCELCDRPVCRDCVVGEHREHPYDFTSNVIHKHGDSVRELLRDTQPHVEALEDALAQIKSVNNALQERVEAVAADVRTFSEGYIKAIEEHRDKLLQQLDDIRIQRETALQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVERLRKLNKVEYSARPGVNHKICFSPQEKAGQCQGYEVYGAINTQEVDPAQCVLQGEDLHRAREKQTASFTLFCKDASGQSMGRGGDNVHVEVVPKDKKDSPIRTVVQDNKDGSYRVSYTPKEPGIYTVWVCIREQHVQGSPFNVTVRRKHRPHPGVFHCCTFCSSGGQKAARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFIEKSECSFTSGQGAPRSLLRTVAL
What is the function of this protein?
May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
What are the official names of this protein?
Tripartite motif-containing protein 45.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RNH_THET2
Sequence: MNPSPRKRVALFTDGACLGNPGPGGWAALLRFNAHEKLLSGGEACTTNNRMELKAAIEGLKALKEPCEVDLYTDSHYLKKAFTEGWLEGWRKRGWRTAEGKPVKNRDLWEALLLAMAPHRVRFHFVKGHTGHPENERVDREARRQAQSQAKTPCPPQAPTLFHEEA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_METVO
Sequence: MDSVKIINAVKEARNSAKPRNFTQSVDLIINLKELDLSRPENRMKQQIVLPSGLGKEINIAVIAKGDLAAQAESMGLTVIRQEELEELGKNKKQAKKLANANQFFIAQADMMPIVGKSLGAVLGPRGKMPQPVPANANLKPLVERFGKTISINTRDKAFFQVYVGKESMSDEELAANIEAVLNTVARKYEKGLYHVKNAFTKLTMGASAPIEK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: VP54_CPSVP
Sequence: MSMASFKSASKRISGTENVTRISANTAINSIVKKGELNVISLKDGNTADLEGINDVLLDYRRILKNEIKTAVSPITMKLKKDEHKKKLKLGTLKSITDKLRKLGGESSQPFIQFYKVQCMYIPLFSRVDGDNGEITVSLIDDGKEAAGQDPIIQSITFDASQMAMVELSMNFFVEKKDMDFIGIHVSAENVPVQDRAYGSINLAFFTNEQSVPMMQEEKKSSYLMIDAVNRPNDITKSSVFKSIGDRVSEEINQKRDDYKKKLIENEKLRRREGKGVKIETETRSSSSSDGETLLEEARKSVSLNISKFLADQRRAPPPPQLEKRTFQWPCGVKMLTMMDTGSSSHYFFSKNITPTSVEMNFGGVAQLEVERAKLSFETFGNKFLLKDVFMFSDQSLGDNILSYTLLKEEGHIDGMRTAGDDVLLEKDGEVVMILDSRDEGRMWIKDDVWAEVTEHGSKSAREYCMKVEKNEIKVE
What are the official names of this protein?
Uncharacterized 54 kDa protein.
Protein: NRDR_CLOBH
Sequence: MKCPYCAYGESKVVDSRSTEDGSSIRRRRECLKCNRRYTTYEKIETTPILVIKKNMSREYFDRNKIVNGLMKACQKRPVSRKQIEQIANEVERHISNEMLTEVNTDKIGQIIMKNLKKIDEVSYVRFASVYRQFKDINTFMEEIKNLMDKN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: Y1794_STRCO
Sequence: MTELKRRPLPHDFHPPVPSFTVTSEDVPEGGTLKDDQVHAAGNTSPHLRWEGFPAETKSFAVTCYDPDAPTGSGFWHWVVFDIPASVTELPVGAGSGAFEGLPQGAVQARNDYGSKGFGGAAPPPGDGPHRYVFTVYAVDQEKLGPDADGTPAFVGFNLRFHTIARAHLISEYEVPADS
What are the official names of this protein?
UPF0098 protein SCO1794.
What is the protein family that this protein belongs to?
Belongs to the UPF0098 family.
Protein: PYRR_HAEIE
Sequence: MEKIIIDHDRFLRTISRISHEIIEKHQTLDDLVIVGIKRRGAEIAELLQRRVEELSGINLPSMELDITFYRDDLTLVDQEDKMPVYSGSSQYLNIQDKTVILVDDVLFTGRTIRAAMDALTDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRDELVQVRTEKQDGCYEVAILGK
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: LFTR_YERPE
Sequence: MRVTQLSSQSFIFPSPELALREPNGLLALGGDLTAPRLLAAYQRGIFPWFNPGEMILWWSPDPRAVLFPEDLHISRSMRRFIRHCPYRFTLNHAFADVISACATERDEGTWIGRDVQQAYCQLHALGHAHSLEVWLENELVGGLYGVAVGAVFCGESMFSRADNASKSALMVFCHHFTQHGGELIDCQVLNAHTASLGAVEIPRNFFLQQLSQLQFSPLPAECWLPQSLNFSSAMQ
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSD_SHIBS
Sequence: MRFAIVVTGPAYGTQQASSAFQFAQALIVEGHELSSVFFYRGGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALNICVAAALRRGIVDETEAGRLGLASSNLQPGFTLSGLGALAEASLTCDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTHP_HAEIN
Sequence: MYSKDVEIIASNGLHTRPAAQFVKEAKAFSSEITVTSGGKSASAKSLFKLQTLALTQGTILTISADGEDEQQAVEHLVALIPTLE
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I.  Phospho-HPr then transfers it to the PTS EIIA domain.
What are the official names of this protein?
Phosphocarrier protein HPr, Histidine-containing protein.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_RAT
Sequence: MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INSI2_XENLA
Sequence: MGDRENVSYGSRPILAQKMNLLLRGFLLFLIGVFLALVLNLLQVQRNVTLFPPDVLSSLFSSAWWVPLCCGTAAAAIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFANNMQLSLTLAALSIGLWWTFDRSRSGLGLGIGISFFATLVSQLLVYNGVYEYTAPDFLYVRSWLPCIFFAGGITMGNIGRQLEMYERKALVEKSHRD
What is the function of this protein?
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of scap and degradation of hmgcr.  Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs).  Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with scap and retention of the SCAP-SREBP complex in the endoplasmic reticulum.  In presence of oxysterol, interacts with scap, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing scap from escorting SREBPs to the Golgi.  Sterol deprivation reduce oxysterol-binding, disrupting the interaction between insig2 and scap, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs.  Also regulates cholesterol synthesis by regulating degradation of hmgcr.
What are the official names of this protein?
Insulin-induced gene 2 protein, INSIG-2.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYM_KORCO
Sequence: MRWIVASAWPYINAVPHLGTLVQVLSSDVFARFLRKMGEEVVFVSGSDEHGTPIEIEAIRKGIAPRDLTDKMHAYITWLFESFGISYDNYTRTESDVHKEFVRDFYLKVYNEGHIFERETEQLYCPKDEMFLPDRFVTGTCPYCGYERAHGDQCDRCGRLLNPTDLIDPKCSICGSVPEMRRTKHWFFDLPKFSERLRKYIEENENLPENAKTLSLSMIEEGLRPRSLTRDNKWGIPAPFPGSEGKTIYVWMEAVLGYVSAVKEYFLKRGEAERFEEFWKSGDTRSVYFIGKDNIPFHTIIFPALLMASGEGYALPFSVASTEFLLYEGEKFSKSERRGIWMDEALQLLPADYWRFYMIYMRPELKDASFSWEDFESKVNDELNDTIGNLVHRILSFIASRYSGQIPSVELDEEASGFLMRVREIGREIEENLMKIKLRDALRSLIEMARLGNKFFNNREPWKDFESNRGRADSTILASYILLKILAFYMHIFMPSSAEKLWKMLGLEGEPEDRVAFSYHDNGKVSSLEPLFRKIKKEELINRLNQIRERGEVLSARES
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARL8B_RAT
Sequence: MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS
What is the function of this protein?
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states.  In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation.  Along with its effectors, orchestrates lysosomal transport and fusion.  Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes.  Required for lysosomal and cytolytic granule exocytosis.  Critical factor involved in NK cell-mediated cytotoxicity.  Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity).  In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity).  Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense.  Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes.  Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing.  Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity).  Involved in the process of MHC II presentation.  Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity).  May play a role in chromosome segregation (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 8B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Cell projection, axon. Synapse. Cytolytic granule membrane. Note=GTP- bound form resides on lysosomal membranes, whereas GDP-bound form is likely associated with microtubular structures. Localizes with microtubules at the spindle mid-zone during mitosis (By similarity). In dendritic cells, localizes to MHC II+ compartments (By similarity).