PharMolix/UniProtQA huggingface dataset:
Protein: Y2522_SHEB9
Sequence: MIFYLHGFDATSPGNHEKMRQLQFIDPDVRLVSYSTLHPKHDMQHLLKEVAKQMKHSDDPAPLMVGVGLGAYWAERIGFLNGLKSVLINPNLHPEDNMQGKIDRPEEYADIANKCVSQFREKNTHKAMCIFSVNDEMFDNQQLASELSAYYSIDWDDVQPHKFPQLAAHLPKIKAFKLA
What are the official names of this protein?
UPF0227 protein Sbal195_2522.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: MTNN_ACTSZ
Sequence: MKIGIVGAMAQEVEILAGLMTDKTEHKIGSAVVFEGEVNGKSVVLLQSGIGKVAAAIGTTVLLQGFKPDVVINTGSAGGVAQGLKVGDIVISTETAYHDADVTAFGYAKGQLPACPATFKSDEKLTALAEKIAQKQGRRVKQGLICSGDSFIAGGERLAQIKADFPPVTAVEMEAAAIAHVCHAFGVPFVVVRAISDAGDGEAGMSFEEFLPIAAKQSCEMVLGMLAELE
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: NUOI_PSEAB
Sequence: MIKEIINVVHGTFTQLRSLVMIFGHAFRKRDTLQYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEKHDLLISGPGKNPDYNYYRVAGMAIAGKPKGAAQNEAEPINVKSLLP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CBIM_LIMRD
Sequence: MLKVIKKYRKFITFLMIGLVYTLAYPATAHAMHIMEGMLPPRWCIFWYAVSLPFFIYGLYRMYKIVNSGVPNAKVMLALCGAFVFVLSSLKLPSVTGSCSHPTGVGLGTVLFGPGVMSVLGVIVLLFQALLLAHGGITTLGANEFSMTIVGPIVGYAVWKLCRAMKVSRSVSLFLCAMFADWSTYVTTAFQLAIVFPDPNGGVAAALIKFLSIYAITQIPLAIAEGLLTVIVYNLVISNDLWKESALQ
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
What are the official names of this protein?
Cobalt transport protein CbiM, Energy-coupling factor transporter probable substrate-capture protein CbiM, ECF transporter S component CbiM.
What is the protein family that this protein belongs to?
Belongs to the CbiM family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS11_YERPP
Sequence: MAKAPIRARKRVRKTVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCAEAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: YR636_MIMIV
Sequence: MIDHFIMNKLPLELVYYLTNWLKDYDKRMLLSTCKNFLSLQSCVYYEDIYYYEEIHKLSYHQMFRKVELELCKFKTPIPKIVTNLEFDVYFNEPLINRRIKIRNKWVKIRKIIPSTVKYLDMGYSFNKSIRGALSYGLTTLIFGPEFNQPIDNYIPQTVTYLEFSVYFDQPVVGYLPTRLTHLIFGTDFNQPIKGALPDTLEYLYFGWAFNQPIDFALPPNLKCLKFGHCFDQPIKGFLPLGLEKLIFEAEYHQPMDLAIPESVEYLKLGNPGSNSLENCLPINLKTLVFGENFNENLNTLSLDKFRELEKIEFDGFFDQKISSRITIDNVIKSNNFIETFQNFYGMIKYYFNDFINPNRQYLPENVKHIIISTYLYDKICSNISNDVFIEVYN
What are the official names of this protein?
Putative FNIP repeat-containing protein R636.
Protein: ILVD_PYRCJ
Sequence: MVRVRIRSPSWYDGVDNAPHRVYLRAVGFTEEDFSKPLVGVAVSWSELGPCNYHTLELARYVKEGVKEAGGAALAAPTIVVNDGINMGTPGMRYSLISRELIADSIEAQFNAHGVDAWVGIGGCDKTQPGIIMAMVRLNLPSVYLYGGSAEAGWLGERELTVEDVFEAVGAYYAGRITLEELKRVEELSFPTYGTCQGMFTANTMALLAEAMGVSLLGSATPPATSARRRKFAVESGKAAVRALELGIKPRDVVTYDALYNAAVALFATAGSTNAILHLLAIAHEAGVKFALEDFDKIGKRVPVIAALRPAGPYAMQDLDRVGGVPRLLKKLYKAGLLRGEALTVEGEPIGKLLERWEPPAVPEAGVLYDVDRPYKPHGGIRILWGNLAPRGAVMKIGAAEVLKFEGKALVFDGEAEAFKAVAAGEVKPGHVVVIRYEGPKGAPGMPEMLKVTAAIVGAGLGESVALVTDGRFSGATRGIMVGHVAPEAAAGGPIALVENGDRIVIDGEAGLLKLDVSDEELERRRRQWTPPPPKYKGGLLAKYAALVSQADQGAVTTPETCQC
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: THIC_XANCP
Sequence: MNAAPTVLLQQTQTLSAAVTQPIPGSRKIFVQGSRADLQVPMREIVLTRTPTLFGGQDNPPLSVYDTSGPYTDPQAAIDLAAGLAPLRADWIAERGDTLPLEALSSSFGRGREHDARLDAVRFPSRRLPRVARSGANVTQMHYARRGIITPEMEFVAIRENQRLEAVTDAVLRKQHPGEAFGAAIQQRITPEFVREEIARGRAILPNNINHPESEPMIIGRNFLTKINANIGNSAVSSGIAEEVEKLVWSIRWGGDTVMDLSTGKHIHETRDWIIRNSPVPIGTVPIYQALEKVDGRAEELTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTARRVTGIVSRGGSILAKWCLAHHKENFLYTHFEDICEIMKAYDVAFSLGDGLRPGCIADANDAAQFGELETLGELTKLAWKHDVQTMIEGPGHVPMQLIKENMDKQLRECGEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNRQDVRDGIMAYKIAAHAADLAKGHPGVQVRDNALSKARFEFRWDDQFHLGLDPEKAKEFHDETLPKDAHKLAHFCSMCGPHFCSMKITQDVRDYAAEHGISEDHALEAGMQEKSGEFVAQGAQVYRAS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: IAH1_RAT
Sequence: MSLCELAASGSSLLWPRVLLFGDSITQFSFQQGGWGTLLADRLVRKCDVLNRGFSGYNTRWAKIILPRIIRKGAGLENPVAVTIFFGANDSTLKDENPKQHVPLDEYSANLRDMVQYLRSVDIPKERVILITPPPLCEAAWEKECILKGCKLNRLNVAVGEYAKACLQVARDCGTDVLDLWTLMQKDNQDFSSYLSDGLHLSPLGNEFLFFHLWPLLDKKVSSLPRLLPDWKDVEETKPELSLLGDGDH
What is the function of this protein?
Probable lipase.
What are the official names of this protein?
Isoamyl acetate-hydrolyzing esterase 1 homolog, Hypertrophic agonist-responsive protein B64.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
Protein: MGSA_SHIFL
Sequence: MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRLK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: PCBP2_HUMAN
Sequence: MDTGVIEGGLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIITLAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVKQICVVMLETLSQSPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSETGGMGSS
What is the function of this protein?
(Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074).  Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).
What are the official names of this protein?
Poly(rC)-binding protein 2, Alpha-CP2, Heterogeneous nuclear ribonucleoprotein E2, hnRNP E2.
Protein: CYSI_VIBC3
Sequence: MSANQNPSVQEVLGEVLGPWSDNERLKRESHFLRGTIEQDLQDRITGGFTADNFQLIRFHGMYQQDDRDIRAERSKQKLEPLHNVMLRARMPGGIITPHQWLAIDKFATEHTLYGSIRLTTRQTFQFHGVLKPNIKLMHQTLNSIGIDSIATAGDVNRNVLCTSNPVESQLHLQAYEWAKKISEHLLPKTRAYAEIWLDGEKIEGPDEEPILGSNYLPRKFKTTVVIPPHNDVDVHANDLNFVAIGENGQLIGFNVLVGGGLAMTHGDTSTYPRRADDFGFIPLEKTLEVAAAVVSTQRDWGNRSNRKNAKTKYTLDRVGVEVFKAEVEKRAGITFAPSRAYEFTSRGDRIGWVEGIDGKHHLTLFIENGRILDFPGKPLKTGVAEIAKVHQGDFRMTANQNLIVAGVPADQKQQIEQLARSHGLIDDGVSEQRINSMACVAFPTCPLAMAEAERFLPSFVTEVEGILAKHALPKEENIILRVTGCPNGCGRAMLAEIGLVGKAPGRYNLHLGGNRNGTRIPKMYKENITDTQILQEIDELVGRWASERLDGEGFGDFTIRAGIIEEVIISKRDFYA
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: RNFH_PSEU2
Sequence: MADASIQIEVVYASVQRQVLKTVDVPTGSSVRQALALSGIDKEFPELDLSQCAVGIFGKVVTDPAARVLEAGERIEIYRLLVADPMEIRRLRAARAREKRGLPG
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: MYO1E_MOUSE
Sequence: MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEVEMYQGAAQYENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFSEEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIESKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPVWRGDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKTWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEERPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGVVKEVLKRRIEVERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPKNSRPTRRNTVTSRGYPGGTKNNYPMRAAPAPPGCHQNGVIRNQFVPPPHAFGNQRSNQKSLYTSMARPPLPRQQSTGSDRLSQTPESLDFLKVPDQGVAGVRRQTSSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI
What is the function of this protein?
Myosins are actin-based motor molecules with ATPase activity.  Unconventional myosins serve in intracellular movements.  Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments.  Binds to membranes containing anionic phospholipids via its tail domain (By similarity).  Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated ve (By similarity)sicles.  Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function.  In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity).
What are the official names of this protein?
Unconventional myosin-Ie, Unconventional myosin 1E.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasm, cytoskeleton. Note=In podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with F-actin (By similarity). Detected in cytoplasmic punctae.
Protein: PVK1_PANSS
Sequence: GSSGLIPMGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, PanSp-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS7_STRCO
Sequence: MSRVGRVERTTKETSVLVEIDLDGTGKTDIATGVGFYDHMLDQLGRHGLFDLTVKTDGDLHIDSHHTIEDTALALGAAFRQALGDKVGIYRFGNCTVPLDESLAQVTVDLSGRPYLVHTEPENMAPMIGEYDVTMTRHILESFVAQAQVALHVHVPYGRNAHHIVECQFKALARALRYASERDPRAAGILPSTKGAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_CLOBA
Sequence: MKFYDLMCKAAQDVGLELSKEQYEKFIIYKNLLQEWNEKVNLTAITEDEDIIKKHFIDSIKAFKRDEFKEAKTLIDVGTGAGFPGIPVAIMNENIQVTLLDSLNKRVNFLNLVTEKLGLKNVVAIHSRAEDGARQKNLRESFDIATSRAVANMSVLSEFCLPYVKINGHFIALKGPAVEEEIKDSDKAITTLGGQLLDICEVEIEDTELKHNLVVVKKIKECPKVYPRKAGNVTKKPIK
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_SHEPA
Sequence: MPWIQLRIDTDGPNADAISDQLMEEGSLSITFEDGKDNPIYEPTLGETPLWSHTVIVALFEANFDLTPVVERLKLLPCLGDNFSHKVEQVEDKDWEREWMDNFHPIKFGDRLWICPSWREIPDPTAVNVILDPGLAFGTGTHPTTALCLEWLDGLDYSNKDVIDFGCGSGILAVAALKLGAERVTGIDIDYQAIEASKANAERNGVEDKLALYLPEDQPADLLADILVANILAGPLRELAPLIAEKVKPGGLLALSGLLQEQAEEISAFYSEWFNMDEPAHKDDWSRLTGIRK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1154_HAEIN
Sequence: MLLVNLAIFIAFLLLLAQLYRKTEKLGQTVFIGLLLGLLFGAVLQSAFEKPLLDKTLDWINVVSNGYVRLLQMIVMPLVFVSILSAIARINQTRSLGKVSVGVLSTLLITTAISAAIGIAMVHLFDVSAAGLIVGDRELAAQGKVLDKAGQVSNLTVPAMLVSFIPKNPFADLTGANPTSIISVVIFSALLGVAALSLGKEDQALGERIAQGVETLNKLVMRLVRFVIRLTPYGVFALMIKMAATSKWADIVNLGNFIVASYAAIALMFVVHGILLFFVKVNPVDYYKKVLPTLSFAFTSRSSAATIPLNIETQTAKLGNNNVIANFAATFGATIGQNGCGGIYPAMLAVMVAPMVGIDPFSFSYILTLIFVVAISSFGIAGVGGGATFAAIVVLSTLGLPLELIGLLISIEPIIDMGRTALNVNGAMVAGTITDRLLNK
What are the official names of this protein?
Uncharacterized symporter HI_1154.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SMIM3_HUMAN
Sequence: MDAVSQVPMEVVLPKHILDIWVIVLIILATIVIMTSLLLCPATAVIIYRMRTHPILSGAV
What are the official names of this protein?
Small integral membrane protein 3, NGF-induced differentiation clone 67 protein, Small membrane protein NID67.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SSRP_LEPBL
Sequence: MANKKEEPGHSPLVNKKAKFNFELVSFIEAGIVLSGSEVKSLREKKGNLTDAFAKIKNGEVFLENFSITPYKNGGYVNHPEIRPRKLLLHKKEIEKLERQVKEKGLVLVATKVYFKNNLRVKVEIAVGKPKKIHDKRDDMQKKDAQQEIARALKSSNRYE
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MUTS2_CALS8
Sequence: MNQKTLKALEYDKIVEILKNMAKSTPAKEYFENLIPSTNLADIENELNKVDEGYRYVLKYGNPPTLEFENILPSLKKSKLGATLNPHEILQIGKVLKLSYEMRSYLSYTQDFSFLESMKKRLVNLKEVISRIDQTFLTADEILDTASPRLKEIRDRIRKLESRIRDELNSMIRDPKIQRFLQEPIITIRGEKLLLPVKAEFRNEVKGIVHDQSATGATLFVEPFVCVEISNQIRILKSQEKEEIERILQEISSLIASYCDEIETSFYALVELDIVFTKAIWAKEMNASKPVINTSGIINLKKARHPLIQKDKVVPIDIHLGKDFDVLIITGPNTGGKTVTLKTVGLFCLLCQSGIFIPADEDSQLCIFQKIFADIGDDQSIVQSLSTFSAHMKNIIEITKNADDKTLVLLDEIGAGTDPEEGAALAKAILKYLSEKGSKVIATTHYGELKIFAQQEDRFENASCEFDVKTLKPTYRLLIGIPGRSNALVISSNLGLDKGIVEMARGYLSQKTIDLDRIINEMEQKRKEAEENLELARKLKLEAQALKAAYEEEKKRFETERERIRKKAINEAKEIVERAQYEIENLFKDLRKLAENLKEKEVLKELEEKKREYERLIQSISQQEKQEAESKTKKTLQNIRLGQKVYVRSFDAVGFVESLPDSKGNLTVQIGIMKLNVNISDIEEVEEGEKKVYQTTSKNVKLREKSVDLSIDVRGKTSDDAILDVDKYLDDAYTSGLRQVTIIHGKGTGVLRQAIRNFLKRHPLVKSFRDGTYGEGEQGVTIVELRD
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: NDK_PSEPW
Sequence: MAVQRTFSIIKPDAVAKNVIGKITTRFEEAGLKIVASKIKQLSKAEAEGFYAEHSERGFFGDLVAFMTSGPVVVQVLEGENAIALNRELMGATNPKEAAAGTIRADFAESIDANAVHGSDSEAAAAREIAYFFAATEVTTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPS_SYNE7
Sequence: MAVETIQKPETTTKRKIAPRYRVLLHNDDFNPMEYVVMVLMQTVPSLTQPQAVDIMMEAHTNGTGLVITCDIEPAEFYCEQLKSHGLSSSIEPDD
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: NADE_BACCQ
Sequence: MTLQEQIMKALHVQPVIDPKAEIRKRVDFLKDYVKKTGAKGFVLGISGGQDSTLAGRLAQLAVEEIRNEGGNATFIAVRLPYKVQKDEDDAQLALQFIQADQSVAFDIASTVDAFSNQYENLLDESLTDFNKGNVKARIRMVTQYAIGGQKGLLVIGTDHAAEAVTGFFTKFGDGGADLLPLTGLTKRQGRALLQELGADERLYLKMPTADLLDEKPGQADETELGITYDQLDDYLEGKTVPADVAEKIEKRYTVSEHKRQVPASMFDDWWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: FTSW_HALED
Sequence: MSRLARLREQLSTRDHFCDGWLLVATLSLMLIGWVMVTSASTEVATSLTGNPWYFSVRHGVFVLCSMVVALLVLRIPMAWWKANGPLLLLVGLALLALVLVAGREVNGSRRWLSVPGIPLNLQASEIAKLCLIVYLAGYLERFLPQVRRHWGAFLRPLMVMAVMGVLLIFEPDYGAVVVMTGCVMGMLLMAGAPWGRFLLLMGLVAALGAALAIAEPYRMARLTSFVDPWADQFASGYQLTQALIAFGRGEWFGTGLGNSVQKLFYLPEAHTDFVFAVLAEELGMIGAVAVIGLFALLVWRAMAVGRRAELAKRPFAAYLCYGIALVIGAQAFINIAVSTGMLPTKGLTLPLLSYGGSSLVISAVMVGMLLRVDIETRQARRREQPAAPRTGEARS
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: NDB4V_TITSE
Sequence: RLRSKGKK
What is the function of this protein?
Strongly inhibits acetylcholine esterase in vitro.  Increases Il-6 secretion from macrophages in vitro.  Has no antifungal, antiviral or cytotoxic activity.
What are the official names of this protein?
Venom peptide 7.1, Venom peptide 7.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS9_STRT2
Sequence: MAQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDLEEYIPHADLRLVINQPFAVTSTEGSYDVHVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAGLLTRDARMVERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: UREF_STRT1
Sequence: MNINPFANVSLQDYLEIVQIVDSTFPIGSFNHSFGMENYLREDTVTDDKGYEEWQEAYLASQFKYGEGLVIKLVYDAMVTDNIDQVWYYDKVLTVSTQARETRQGTKMIAKQMLRLIQRLHAIPVLDDYQSKIRKGVAFGNPAIVFALYVFNKGLGCNEAIALYGYSVISTMVQNAVRAIPLGQFAGQEIVLRSFSQLEKMTQEIQELDASYLGANTPGLELAQMKHETQVFRLFMS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYCN_HUMAN
Sequence: MSPLRPLLLALALASVPCAQGACPASADLKHSDGTRTCAKLYDKSDPYYENCCGGAELSLESGADLPYLPSNWANTASSLVVAPRCELTVWSRQGKAGKTHKFSAGTYPRLEEYRRGILGDWSNAISALYCRCS
What is the function of this protein?
Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other.  May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity).
What are the official names of this protein?
Syncollin, Insulin synthesis-associated protein 1.
What are the subcellular locations of this protein?
Zymogen granule membrane; Peripheral membrane protein; Lumenal side. Zymogen granule lumen. Note=Associated in a cholesterol- dependent manner with lipid rafts of zymogen granule membranes.