PharMolix/UniProtQA huggingface dataset:
Protein: VF129_ASFM2
Sequence: MEHPSTNYTPEQQHEKLKHYVLIPKHLWSYIKYGTHVRYYTTQNVFRVGGFVLQNPYEAVIKNEVKMAIRLQNSFNTKAKGYVTWTVAYNDISKLYAKPDAIMLTIQENVEKALHALNQNVLTLASKIR
What is the function of this protein?
Plays a role in the inhibition of type I interferon signaling pathway.  Mechanistically, specifically interacts with 2',3'-cGAMP and cleaves it via its phosphodiesterase activity.  In turn, prevents 2',3'-cGAMP interaction with host ER-resident STING1 leading to inhibition of downstream signaling pathway and type I interferon production.
What are the official names of this protein?
Uncharacterized protein C129R, pC129R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus C129R family.
What are the subcellular locations of this protein?
Virion.
Protein: IE1_HHV6U
Sequence: MEPAKPSGNNMGSNDERMQDYRPDPMMEESIKEILEESLMCDTSFDDLIIPGLESFGLIIPESSNNIESNNVEEGSDGELKTLAAQSAGNCIQSIGASVKAAMKQEQSDMEDKLIKCAGLLTQQQSMFIGLGLEQLSQLININLLSSASTKYVESYSKMLHGKELDFFNWCEPRFIVFACDKFDGLVKKVASESRNLLLDLRANMNNDIIKAVKDIFSKATVTLDCQKLNQGATMLMMMAHNKEMSNPDISSKDFCEKINTLKQTLLEGKNEIVETNAKNMQILQTFAIKQMNQIFMDGCDKAFLKLNVNCKNLITAAKNLANTILQSIVICSNEFSWQHLKLLRRGFKVTMLNMITQACECLESDYDDTGLIKPLTPLQIMDGYINMNKNRQSSICDGNTDPSDSMILDLADFDDHGRYSEESSIESIHEDDDNKMYPCTPSPEVPGKSKYVGTFTENSRQSGDEQTNPNCVGTASVTDLGGPDNLNSISGLQSCKNMLLERLLDTQCDSVVEGTEQDGSYGNTLISEMMMFGYETDHSAPYESESDNNDEIDYIANSDSAARTNNIHMNSTDENTPFSNSICSPPEVTPSKKNVKPKSMTPGSKPKKRVAKRKHVSSKSPKNKKIKTDQLPKAADVIVISSESEDEEDGDNIIGNSILIKAIKSESDSESSSESNDCTSEHKQLHLSDYDEVTNNGHCPSYGFPTPVFTIPIRSMQGTGGIKSKFIPKKNWIWYMKKTHQVDNCPIHNSENVDAKDDSDGTEAKHCFMNHFVPIKTDDEDYDKNNVSYIYNKIQNSKIDSGDIIPTKKLIIDMVMDNFMDLNDIIKQGITKHCQDLCNKYNVVTPTTCEDDLNMTNSQTFATTATQVFDPPVTGNNSSILNIINDTTSQNDENRCTEGTSNSNEKCTNISDCNSDGTEAFKLDGYPSDYDPFVENAQIY
What are the official names of this protein?
Immediate-early protein 1, IE1, Protein RF2/RF3/RF4, pRF2/pRF3/pRF4.
Protein: RM34_HUMAN
Sequence: MAVLAGSLLGPTSRSAALLGGRWLQPRAWLGFPDAWGLPTPQQARGKARGNEYQPSNIKRKNKHGWVRRLSTPAGVQVILRRMLKGRKSLSH
What are the official names of this protein?
39S ribosomal protein L34, mitochondrial, L34mt, MRP-L34, Mitochondrial large ribosomal subunit protein bL34m.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DRRB_MYCTU
Sequence: MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP
What is the function of this protein?
Part of the ABC transporter complex DrrABC involved in doxorubicin resistance.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Doxorubicin resistance ABC transporter permease protein DrrB.
What is the protein family that this protein belongs to?
Belongs to the ABC-2 integral membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL14_THEFY
Sequence: MIQQESRLKVADNTGAKELLTIRVLGGSGRRYASIGDTIVATVKDALPGAGVKKGDIVKAVVVRTTKERRRPDGFYIRFDENAAVLIKDGGDPRGTRIFGPVGRELRDKKFMRIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: LEUC_THEVB
Sequence: MSMSRGTLFDKVWEQHTVATLPSGQTQLFIGLHLIHEVTSPQAFAMLRERGLPVLYPQRTIATVDHIVPTDTLARPLQDALAEEMLQALEANCRAHNIPFFGIGSGRQGIVHVIAPEQGLTQPGMTIACGDSHTSTHGAFGAIAFGIGTSQVRDVLATQTLALNKLKVRKVEVNGSLAAGVYAKDVILHVIRHLGVKGGVGYAYEFAGTTFGQLSMEERMTVCNMAIEGGARCGYVNPDETTFAYLKGRPFAPQGKAWDEAVAWWRSLASDADAEYDDVVTFAAADIAPTVTWGITPGQSVAVDETLPTLESLPVAERAIAAEAYAYMDLQPGQPIQGTKIDVCFIGSCTNGRISDLRQAAKVVEGRKVKPGVKAFVVPGSERVKAQAEAEGLDVVFKAAGFEWRNPGCSMCLAMNPDKLQGRQISASSSNRNFKGRQGSPSGRTLLMSPAMVAAAAIAGEVTDVRAFL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: NADM_PYRAE
Sequence: MKRALFPGRFQPPHWGHVYAVREILKEVDEVIITVGSAQFNYILKDPFTAGERIWMLREALREGGIDLSRVVIIPVPNVENNLEWLGRVKSLAPPFQIVYTGNPFVALLFKEAGYEVRQQPMFRREQLSSTRVRELILKGDPQWEELVPKSVAAIIKAIGGAERLRIAALGEAEPHKW
What are the official names of this protein?
Nicotinamide-nucleotide adenylyltransferase, NAD(+) diphosphorylase, NAD(+) pyrophosphorylase, NMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the archaeal NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_STAAS
Sequence: MAISQERKNEIIKEYRVHETDTGSPEVQIAVLTAEINAVNEHLRTHKKDHHSRRGLLKMVGRRRHLLNYLRSKDIQRYRELIKSLGIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: MRS2_PLABA
Sequence: MFRWLNINKCMSKIIHPYVLKPNNCIHTNWLFKFATLKNENKIFPKKNLNNNILMQNIKVADDGNAICEQLLFSKYDLPYLLKIPVSDLRLIDTGNNNHNPTILIRKDVILLRTGFISCIIRYNETWLFEGSNSVVINAKDLISKNLKKQNNNKFKNCNNDEIVESLCRKRNCTDNGKENMKQINNDEKEELNYLNIINNFYRYNKGKAYFEFLCLDICMQLSIKEYENDLEGINYKIRDIILLQRKEENNELNMLTNKLLRDMMKIKNNLQKLSNLLNALRTNIEKILNNENDMKNMYLTYLNKNPYNNLKDCSDLEILLETHLQLTDELYGQLENVEEKITHYEELMRLNLDYNRNKFILLNAKISFSTLLFSISSVVTSLFGMNLKNFVEDSNYAFIIVSIFVSVWSIIGIYVTKNINTLLKFFDRYNFR
What is the function of this protein?
Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis (By similarity).  Involved in the development of the sporozoite in the mosquito vector midgut (PubMed:26796412).
What are the official names of this protein?
Mitochondrial inner membrane magnesium transporter MIT1, PfMIT1.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LRFN1_MOUSE
Sequence: MAPGPFSSGLFSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRKVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGGGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSTSERRLVAAELTSSSVLIRWPAQRPVPGIRMYQVQYNSSADDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRIKGTSRTPPRVSHVCSQTNGAGAQQASAPPAPDRYEALREVAVPAAIEAKAMEAEATSTELEVVLGRSLGGSATSLCLLPSEETSGEESRAMTGPRRSRSGALGPPTSAPPTLALVPGGAPARPRPQQRYSFDGDYGALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARARLAFTSTEWMLESTV
What is the function of this protein?
Promotes neurite outgrowth in hippocampal neurons.  Involved in the regulation and maintenance of excitatory synapses.  Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1.
What are the official names of this protein?
Leucine-rich repeat and fibronectin type III domain-containing protein 1, Synaptic adhesion-like molecule 2, Synaptic differentiation-enhancing molecule 1.
What is the protein family that this protein belongs to?
Belongs to the LRFN family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Synapse. Postsynaptic density membrane. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane.
Protein: ARGC_XANOM
Sequence: MTVQTTTIGIVGARGHTGSELIKLVAAHPHLQLVFVSSRELAGQRVAEHNQAYQAELRYESLDANAVAAKAADVVILALPNGNAAPFVAAIDAATPQTLVIDLSTDYRFDPAWYYGLPELTRGSYAGQKRISNPGCYATAMQLTIAPLLDQLAGPPQCFGVSGYSGAGTTPSDKNNPALLADNLMPYALTNHMHEREVSAQLGVPVEFMPHVAPHFRGITLTVNLWLQQPLTREQIQARYTQRYADEPLIEIVDEAPWVSRIAGRHGVQIGGVTLAPGNKRVVVVATLDNLLKGAATQAMQNLNLALGWDELTAIG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TENS4_MOUSE
Sequence: MSSSLLAGGHMVSLTPCEESRMALHPTPSPGLPALCPYYTTESWGTQPLMAPTLRKGSSDRLQQAQQAEARAHCLLQGPGEQASGASQDLESCIDFSLEALNQMILEIDPTFQLLPSGTAGPQAESTNSIMSRNKKEEPEALDIKYIEVTSTRSRYLDGPQRCSSPCATPPFGSPRSGSLFLSRDIPRETRSSSNESLIFSGNQGRGPSPLTPSSLSNAIPCRESRTSGSPLATPPGWEKGLRAPQRGSRVSILSASPVSDVSYVFGSNQSLPHSSLSSYPSSSRSLGSPASSSSSLHSLDRGSQCGRPSDAQAPSNPILGMGQPQAVQSTPVAKEQASSCPASVTNSMADIPIVLINGSPEPQSPPAQRTPGHQDSVQSRVTSPSHLCQAIKSPSKTLPDVPLPASPDGPAKDMQPTMKFVMDTSKYWFKPSITREQAINLLRTEKPGAFVIRDSSSYRGSFGLALKVQETSASAPNRPGEDSSDLIRHFLIESSAKGVHLKGADEEPYFGSLSSFVCQHSIMALALPCKLTIPQKELGGAEPASDSPTHGQTSCLKISAGCHTLYLSSVSVETLSGALAVQKAISVTLERDVLPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLSALRFCGMDPEQRKWQKYCKPSRIFGFVAKSQTEPQENVCHLFAEYDAVQPASQVISLVTALLQDTERM
What is the function of this protein?
Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration.  Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF.  Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration.
What are the official names of this protein?
Tensin-4.
What is the protein family that this protein belongs to?
Belongs to the PTEN phosphatase protein family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
Protein: FIBB_LAMVI
Sequence: ATDYDEEEDDRVKVRLDAR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: RS20_BRAHW
Sequence: MPNIASASKRLRQNEVRNLYNRKIKSFLNTQKKKVIKAVDSNDKNLASEEFKKYASALDKAARKSVIHANRAAAKKSDMMKKINAMN
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: MRAY_STRE4
Sequence: MFLTILAGLIAFAVTALAMPHFIRLYQLKKIGGQQMHEDVKQHLAKAGTPTMGGTVFLLVATSLSFVFALVYFRDGQSLGLISGILLIVLIYGIIGFLDDFLKIFKQVNEGLTAKQKFTFQIVGGLVFYVIHVMPSGIDAINVFGYHWHLGFLYLCFVLFWVVGFSNAVNLTDGIDGLASVSVVISLLAYGVIAYAQGQFDVLLLIGIMVGALLAFFLFNHKPAKIFMGDVGSLALGAMLAAISIALRQEWTLLVIGIVYVLETSSVMLQVTYFKYTKKKYGEGRRIFRMTPFHHHLELGGLSGKAAKWSEWKVDAFLWALGLVASLIVLAILYL
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HTPG_CLOAB
Sequence: MAVKQFKAESKRLLDLMINSIYTNKEIFLRELISNASDAIDKCYYRSLVDTNITFNKDDFYIRISADKENKTLTITDTGIGMTKDDLENNLGTIAKSGSFAFKSENEAKEGVDIIGQFGVGFYSAFMVADDVTVISRSVDSEEAYKWESKGVEGYTIEKCEKETPGTEIVLKIKENTDDEKYDEFLDEYKLRSLIKKYSDFIKYPIKMMTKKTRPKKDNDKETEEYLEDETLNSMVPIWRKNKNELKQEDYDNFYMDKHFGFEKPLKTIHSNVEGVVSYNTLLFIPASAPYDFYTKEFEKGLELYSNGVMIMQKCGDLLPDYFSFVQGLVDSPDLSLNISRELLQHDRQLKFIAKKIKEKIKSELLSMAKNDRENYVKFFNSFGRQLKYGVYSDFGSNKEVLQDLLMFYSSTEKKLVTLDEYVSRMKEDQKYIYYAAGESNEKIEKLPQTEVVKDKGYEILYFTDDVDEFAIKMLMKYKEKEFKSVSNKDLGFEADEKESKKETEENKDLFDFMKEVLDGKVKEVRASSRLKSHPVCLSNDGELSIEMEKVLKMMPDNNNVKAEKILEINTNHEMFNSIKAAFKDDKDKLKKYASLLYNEALLIEGLPIEDPVQFANDVASLMK
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_BLOFL
Sequence: MNSTNFFSHDLYLYHQVIRCIVKYRNLLLAYSGGMDSTVLLDILTKLKKYFDFQVKGTSKILPFFLRAVYVHHGLNNKADYWADHCLQQCKMRNVPFHIIYINHSDLSKIKCNIEAMARDFRYKALFNALKPEEVLLTAHHMNDQVETVLLALKRGSGPAGLSGMTQDILYQHNEYQHRLLRPLLKCSHIQLQEYAYRKKLTWVEDDTNTDVRFDRNFLRVQVIPLFQKRWPAFNKVVSRTAQLCREQENLLHELLSESLDQLIDIDNALFFYPLIKYSDVRRRVVLRYWLSRFFINMPSYKLLDCIWKEVALSKVDSQSILHVGKKYICRRFRKKLYILPDNMKSSLDIFLLPWKNFNNTILLPNELGLLTSQSLTVNLFLFYKNLIPYTHLNMLSDIFLPRYHNNVGDEKILSVCFIRPPMNNEKVSIQFGYIQGLLHLANRDRGRKLKKIWQEYNVPPWLRNHIPLLFYNDTLISAIGIFITRNGSCIVNMNNLICNNKKSIILQKITWVQSDFYYRIFKNFVYNTLR
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_STRA5
Sequence: MERNQRKTLYGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKKYKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEKAVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RPIA_STUS1
Sequence: MTQDQLKQAVAQAAVDHILPKLNDRSIVGVGTGSTANFFIDLLAKHKGFFDGAVASSEATAERLKQHGIPVYDLNSVSELEFYVDGADEANKHLELIKGGGAALTREKIVAAVAKTFICIADGSKLVEQLGAFPLPVEVIPMARSHVARELVKLGGDPVYRDGVVTDNGNVILDVHNLMIGFAPELEGKINDIVGVVSNGLFAMRPADLLLLGTQDGVQTLTR
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: SYL_BACC0
Sequence: MSFNHQEIEKKWQGYWEENKTFRTPDETEKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNSPAEFTEHNINTFRNQIKSLGFSYDWDREVNTTDPNYYKWTQWIFLKLFEKGLAYVDEVPVNWCPALGTVLANEEIIDGKSERGGHPVERRPMRQWMLKITAYGDRLLEDLDELDWPESLKDMQRNWIGRSEGAEVHFNIDGTDEKFTVFTTRPDTLFGASYCVLAPEHALVADITTADQKEAVEAYINSVKMKSDLERTELAKEKTGVFTGAYAVNPVNGEKLPIWIADYVLATYGTGAVMAVPAHDERDYEFASTFNLPMKEVVKGGDITKEAYTGDGAHVNSAFLDGLNKEEAIAKMIEWLEVTSAGNQKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTMTAVKEEELPLVLPKTENIRPSGTGESPLANIDEWVNVVDPETGKKGRRETNTMPQWAGSCWYYLRYIDPNNSEALVDPEKVKQWLPVDIYIGGAEHAVLHLLYARFWHKVLYDIGVVPTKEPFQQLFNQGMILGENNEKMSKSKGNVVNPDDIVASHGADTLRLYEMFMGPLDASIAWSENGLDGARRFLDRVWRLFVQDNGELSEKITDAPNKDLEKAYHQTVKKVTEDYAELRFNTAISQMMVFINDAYKAETLPKEYVEGFVKMIAPVAPHIGEELWSKLGYNETITYASWPTFDESKLVEDEVEIVVQVMGKVRAKLTMSKDASKDEMEKLALEAIQDQIEGKTVRKVIVVPGKLVNVVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OCA5_KLULA
Sequence: MPLKPSSSHSERKNRLHLHASSRNAKQQEWNRELVTLFIKLLNENDHASLALVARNAGVPPQLRPAVWPTLLKYHPMVISPNIMSNTLVFKDDENEAELRYFPEDRSEEDISELMENDLNKYFQVRNSVPVSAEIQEIKSLLKECVWQFLRKWNKICKYESGLIWIALGLAEWCPLKNNDDLVLAGRKHHHHNSCLRHLYEEYPIPDELLNQLPDTEFDFAAIYERLVLVLFHAPALDEKPDKSNYHLLKSGNLNQQSQLFFKVFAKTLPELYQPITDEGALQGSKKATWLYWWIKCCGCRVLHRQDRGRVWDVLLGWRPRPESINYYLEYNHKSFESIYPPELKLSSEIFHKICKCEHDEFWFPDLMSLRLGQNGLNQDEDVIRELIRRNKYGDDGHTTETQENEIPYSLLNPHAELLFIYVAIMQHNEFKLLEFEETEITEFLNNVPLISKFDDYNFKKMYEDDDISGSSTDTDESNASGIRPSSSNHMMIEVGTDDKTAHSFDDIYQQAGDIWRNWAWQEMEEFIEE
What are the official names of this protein?
Oxidant-induced cell-cycle arrest protein 5.
What is the protein family that this protein belongs to?
Belongs to the OCA5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_DECAR
Sequence: MTSQSVAKKLNHCFSDQALFRTALTHRSFGTPNNERLEFLGDGVLDFVIAASLYHRFPDLPEGDLSRLRANLVRQETLHRLALELNIGAFLRLGEGELKSGGAQRPSILADALEALFGAIYLDAGFEASRAVIEKLFAPLLDDLKPGQFQKDAKTRLQEWLQGRKKALPRYHLLEATGAAHEQRFEIACEIESPALRTVGHGSSRRIAEQVAAEKALKELLA
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPC_RABIT
Sequence: MGSPLCVPIFLAVCILIQSSTHGQSLRPEPFGRRARVTATKKTLLETETRFLLFKDKANKGCQIRLHHADTLQECGFNSSLPLVMIVHGWSVDGLLESWIWQMVAALKSQPARPVNVGLVDWISLAHSHYAVAVRNARLVGQEVAALLQWLEESAPFSRSNVHLIGYSLGAHVAGFAGSYISGKHKIGRITGLDAAGPLFEGTSASDRLSPDDATFVDAIHTFTREHMGLSVGIKQPVGHYDFYPNGGSFQPGCHFLELYKHIAQHGLNALSQTIKCAHERSVHLFIDSLLHPSMQSTAYQCSDMDSFSQGLCLGCTKGRCNTLGYHIRQEPLSKGKRLFLVTQAQSPFRVYHYQFKIQFINQIEKPLEPTFTMSLLGTKEEMQKIPITLGEGITSNKTYSFLITLNLDIGELMVIKFKWENSAVWANVWNTVQTIIPWGIKPRNSGLILKTIRVKAGETQQRMTFCSENMDDLQLHPTQEKNFVRCEVNPKKLKLKIK
What is the function of this protein?
Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:1770315).  Also exhibits lysophospholipase activity (By similarity).  Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity).  In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity).
What are the official names of this protein?
Hepatic triacylglycerol lipase, HL, Hepatic lipase, Lipase member C, Lysophospholipase, Phospholipase A1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: VP6_ROTGI
Sequence: MDLIETVNACVGLQKRVLKLAPNTNLNTAGQSVLNDYNALASRVNGRTYALLDQTAVYTPYTVNAPIISLAVRISTDDYDDMRSGIDSILDILAAAIRTEGSRPTRVIERRVIEPNVKQLVEDLKLKSLTSEISIANMAAVDTALIQPEIIETENPLFADIIEQVIHRPNASMTGGNIRATLGRWSGNKGIVTCMSGMDSEHRFTVDFKTRTCGIINVVYAPTAGVIMIPMPTGRNREGHLIDVSAEMMAENFAIDFMDDDDIIQTETGVGVFSFPMCNRIRFRINPWDMQKHNDNLWTVNLANWPQGTSPRQPAISFLFETRRTFTEGDYQHLSRCAPKVQYMMDTIFPETAFTNRPVVDWNVQSLLTSSSQKTWCQKIAMLIAAYAAKI
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RPOA_PEDPA
Sequence: MIEFEKPKIHKIDENDNYGRFVIEPLERGYGTTLGNSLRRILLSSLPGAAITSVQIDSVLHEFSTIEGVVEDVTQIILNLKKVSLKIESDEDKTLEINVAGPANVTAGDIMGDGDVVILNPELPICTVAEGTTFHAVLTADTGRGYTSADENKARKVDMPIGVLPIDSIYTPIERVNYQVENTRVGQRDDYDKLTLDIWTDGSITPSEATSLSAKILTEHLAIFVNLNDQAKETEIMVEKEETHKEKMLEMTIEELDLSVRSYNCLKRAGINSVQELTDRTDAQMMKVRNLGRKSLVEIQEKLSLLGLGFRSED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: GLMU_BACC1
Sequence: MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQAEQLGTAHAVDQAASVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEKELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALSQAEIIMKNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQSTVHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGVFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.