PharMolix/UniProtQA huggingface dataset:
Protein: NIFJ_SYNY3
Sequence: MSLPTYATLDGNEAVARVAYLLSEVIAIYPITPSSPMGEWSDAWAAEHRPNLWGTVPLVVEMQSEGGAAGTVHGALQSGALTTTFTASQGLMLMLPNMHKIAGELTAMVLHVAARSLAAQGLSIFGDHSDVMAARNTGFAMLSSNSVQEAHDFALIATATSFATRIPGLHFFDGFRTSHEEQKIELLPQEVLRGLIKDEDVLAHRGRALTPDRPKLRGTAQNPDVYFQARETVNPFYASYPNVLEQVMEQFGQLTGRHYRPYEYCGHPEAERVIVLMGSGAETAQETVDFLTAQGEKVGLLKVRLYRPFAGDRLVNALPKTVQKIAVLDRCKEPGSIGEPLYQDVLTAFFEAGMMPKIIGGRYGLSSKEFTPAMVKGVLDHLNQTNPKNHFTVGINDDLSHTSIDYDPSFSTEADSVVRAIFYGLGSDGTVGANKNSIKIIGEDTDNYAQGYFVYDSKKSGSVTVSHLRFGPNPILSTYLISQANFVACHQWEFLEQFEVLEPAVDGGVFLVNSPYGPEEIWREFPRKVQQEIIDKNLKVYTINANDVARDAGMGRRTNTVMQTCFFALAGVLPREEAIAKIKQSVQKTYGKKGQEIVEMNIKAVDSTLAHLYEVSVPETVSDDAPAMRPVVPDNAPVFVREVLGKIMARQGDDLPVSALPCDGTYPTATTQWEKRNVGHEIPVWDPDVCVQCGKCVIVCPHAVIRGKVYEEAELANAPVSFKFTNAKDHDWQGSKFTIQVAPEDCTGCGICVDVCPAKNKSQPRLRAINMAPQLPLREQERENWDFFLDLPNPDRLSLNLNKISHQQMQEPLFEFSGACAGCGETPYLKLVSQLFGDRMLVANATGCSSIYGGNLPTTPWAQNAEGRGPAWSNSLFEDNAEFGLGFRVAIDKQTEFAGELLKTFAGELGDSLVSEILNNAQTTEADIFEQRQLVEQVKQRLQNLETPQAQMFLSVADYLVKKSVWIIGGDGWAYDIGYGGLDHVLASGRNVNILVMDTEVYSNTGGQASKATPRAAVAKFAAGGKPSPKKDLGLMAMTYGNVYVASIAMGAKNEQSIKAFMEAEAYPGVSLIIAYSHCIAHGINMTTAMNHQKELVDSGRWLLYRYNPLLADEGKNPLQLDMGSPKVAIDKTVYSENRFAMLTRSQPEEAKRLMKLAQGDVNTRWAMYEYLAKRSLGGEINGNNHGVSPSPEVIAKSV
What is the function of this protein?
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.
What are the official names of this protein?
Putative pyruvate-flavodoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
Protein: CP123_MYCTO
Sequence: MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
What are the official names of this protein?
Putative cytochrome P450 123.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: DGKG_HUMAN
Sequence: MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
What is the function of this protein?
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597).  Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity).  Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597).  Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma.  Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity).
What are the official names of this protein?
Diacylglycerol kinase gamma, DAG kinase gamma, Diglyceride kinase gamma, DGK-gamma.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton.
Protein: SPT6_YEAST
Sequence: MEETGDSKLVPRDEEEIVNDNDETKAPSEEEEGEDVFDSSEEDEDIDEDEDEARKVQEGFIVNDDDENEDPGTSISKKRRKHKRREREEDDRLSEDDLDLLMENAGVERTKASSSSGKFKRLKRVGDEGNAAESESDNVAASRQDSTSKLEDFFSEDEEEEESGLRNGRNNEYGRDEEDHENRNRTADKGGILDELDDFIEDDEFSDEDDETRQRRIQEKKLLREQSIKQPTQITGLSSDKIDEMYDIFGDGHDYDWALEIENEELENGNDNNEAEEEEIDEETGAIKSTKKKISLQDIYDLEDLKKNLMTEGDMKIRKTDIPERYQELRAGITDYGNMSSEDQELERNWIAEKISVDKNFDANYDLTEFKEAIGNAIKFITKENLEVPFIYAYRRNYISSREKDGFLLTEDDLWDIVSLDIEFHSLVNKKDYVQRFYAELHIDDPIVTEYFKNQNTASIAELNSLQDIYDYLEFKYANEINEMFINHTGKTGKKHLKNSSYEKFKASPLYQAVSDIGISAEDVGENISSQHQIHPPVDHPSSKPVEVIESILNANSGDLQVFTSNTKLAIDTVQKYYSLELSKNTKIREKVRSDFSKYYLADVVLTAKGKKEIQKGSLYEDIKYAINRTPMHFRRDPDVFLKMVEAESLNLLSVKLHMSSQAQYIEHLFQIALETTNTSDIAIEWNNFRKLAFNQAMDKIFQDISQEVKDNLTKNCQKLVAKTVRHKFMTKLDQAPFIPNVRDPKIPKILSLTCGQGRFGADAIIAVYVNRKGDFIRDYKIVDNPFDKTNPEKFEDTLDNIIQSCQPNAIGINGPNPKTQKFYKRLQEVLHKKQIVDSRGHTIPIIYVEDEVAIRYQNSERAAQEFPNKPPLVKYCIALARYMHSPLLEYANLTSEEVRSLSIHPHQNLLSSEQLSWALETAFVDIVNLVSVEVNKATDNNYYASALKYISGFGKRKAIDFLQSLQRLNEPLLARQQLITHNILHKTIFMNSAGFLYISWNEKRQKYEDLEHDQLDSTRIHPEDYHLATKVAADALEYDPDTIAEKEEQGTMSEFIELLREDPDRRAKLESLNLESYAEELEKNTGLRKLNNLNTIVLELLDGFEELRNDFHPLQGDEIFQSLTGESEKTFFKGSIIPVRVERFWHNDIICTTNSEVECVVNAQRHAGAQLRRPANEIYEIGKTYPAKVIYIDYANITAEVSLLDHDVKQQYVPISYSKDPSIWDLKQELEDAEEERKLMMAEARAKRTHRVINHPYYFPFNGRQAEDYLRSKERGEFVIRQSSRGDDHLVITWKLDKDLFQHIDIQELEKENPLALGKVLIVDNQKYNDLDQIIVEYLQNKVRLLNEMTSSEKFKSGTKKDVVKFIEDYSRVNPNKSVYYFSLNHDNPGWFYLMFKINANSKLYTWNVKLTNTGYFLVNYNYPSVIQLCNGFKTLLKSNSSKNRMNNYR
What is the function of this protein?
Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters.  Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.  Essential for viability.
What are the official names of this protein?
Transcription elongation factor SPT6, Chromatin elongation factor SPT6.
What is the protein family that this protein belongs to?
Belongs to the SPT6 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin (PubMed:2201908). Recruited to the active transcribed loci (PubMed:2201908). Associates with the coding region of HTA1 (PubMed:19683497).
Protein: LOT5_ASHGO
Sequence: MNADRPCCQFVTTKPTVENVTPFAQFQLTQPRLKGVSLQQLSALPILYGGGRNFLFGRFTDSEPQLQDTDLFVLDSCILLWPAHALRGLRIPYDAVIYHAVRRADVLELVLAVERDATLDSLFPPAPGPQPFALSTLELRLRPRYATYDRHYSGAVEQLFTFRDFGLNRGDAMVANCNTAIATCMEFHHRAAAADDDDDDDDGPAAHVTPLAELLAPAGHVPIYANHGSADDLTDDGLTDDGPQGGAAAGMALAFCSAARVPTKRRRQD
What are the official names of this protein?
Protein LOT5.
What is the protein family that this protein belongs to?
Belongs to the LOT5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y1686_STRCO
Sequence: MDGLMSSADEILDIVDENDRVVGQARRGDAYARGLRHRCVFVWARDPEGRVFVHRRTATKLVFPAPYDMFVGGVVGAGESYDDAALREAEEELGASGLPRPEFLFKFLYDDGAGRTWWSAVYEVRVAGAVSPQVEEVAWHGFLPEAELEGRLGEWEFVPDGLSAYARLRAWRGASGPGSVG
What are the official names of this protein?
Uncharacterized Nudix hydrolase SCO1686.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: ATPE_STREM
Sequence: MTQMTVQVVTPDGIKYDHHAKFISVTTPDGEMGILPNHINVIAPLQVHEMKIRRVGEDDRVDWVAINGGIIEIKDNVVTIVADSAERDRDIDVSRAERAKLRAERDIAEAETTHDINEVQRAKVALRRALNRINVSKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SUC8_ARATH
Sequence: MSDLQAKNDVVAVDRQSSSSLADLDGPSPLRKMISVASIAAGIQFGWALQLSLLTPYVQLLGVPHKWSSFIWLCGPVSGLLVQPSVGYFSDRCTSRFGRRRPFIATGALLVAVAVVLIGYAADFGHSMGDKIDKPVKMRAVVIFALGFWILDVANNTLQGPCRAFLGDLAAGDAKKTRTANAFFSFFMAVGNVLGYAAGSYTNLYKIFPFTMTKACDIYCANLKSCFFLSITLLLVVTIIALWYVEDKQWSPKADSDNEKTPFFGEIFGAFKVMKRPMWMLLIVTALNWIAWFPFLLYDTDWMGREVYGGDSKGDDKMKKLYNQGIHVGALGLMLNSIVLGIVSLGIEGISKKIGGAKRLWGAVNIILAVCLAMTVLVTKKAEEHRRIAGPMALPTDGIRAGALTLFALLGIPLAITFSIPFALASIISSSSGAGQGLSLGVLNMAIVIPQMIVSFGVGPIDALFGGGNLPRFVVGAIAAAISSVVAFTVLP
What is the function of this protein?
Responsible for the transport of sucrose into the cell, with the concomitant uptake of protons (symport system).  Can also transport maltose at a lesser rate.  May also transport biotin.
What are the official names of this protein?
Sucrose transport protein SUC8, AtSUC8, Sucrose permease 8, Sucrose-proton symporter 8.
What is the protein family that this protein belongs to?
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2.4) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: INSK_ECOLI
Sequence: MKVLNELRQFYPLDELLRAAEIPRSTFYYHLKALSKPDKYADVKKRISEIYHENRGRYGYRRVTLSLHREGKQINHKAVQRLMGTLSLKAAIKVKRYRSYRGEVGQTAPNVLQRDFKATRPNEKWVTDVTEFAVNGRKLYLSPVIDLFNNEVISYSLSERPVMNMVENMLDQAFKKLNPHEHPVLHSDQGWQYRMRRYQNILKEHGIKQSMSRKGNCLDNAVVECFFGTLKSECFYLDEFSNISELKDAVTEYIEYYNSRRISLKLKGLTPIEYRNQTYMPRV
What is the function of this protein?
Involved in the transposition of the insertion sequence IS150.
What are the official names of this protein?
Putative transposase InsK for insertion sequence element IS150.
What is the protein family that this protein belongs to?
Belongs to the transposase IS3/IS150/IS904 family.
Protein: NMAT2_ARATH
Sequence: MRRSFSVLGPYKWLKPSSTYTNVYCFVTNPPLISNPNNGSAIFRYLSYFAPQQRRQQQQAPDPDDPANLLKEDGVSLCSQMWLENFKEPDKTATNLTSYLRRFELWVLAYQKVCCDELGAYVPRSSIQRSALENLLALRNSVLDDRFKWGSRLDFYIKSPRDKTDYESLSKRKIKAILTTTQPTPFQDRIVQEVLLMILEPIYESRFSQKSFAFRPGRTAHTVLRVIRRNFAGYLWYVKGDLSVVLDGMKVGFVISSLMRDVRDKKVIDLIKSALVTPVVTSKVEDGEKKKTKKRKYQKKRVLAEDEPKPDPYWLETFFGFAPEEAGKSPQWGHCGILSPLLVNVCLDELDRWMETKVKDFYRPSKSDVIWNNPEGEADQGNTSWPEFVPTSGPDKTRKMDYVRYGGHILIGVRGPRADAATLRKELIEFVDQKYMLRLDNENLPIEHITKGIMFLDHVLCRRVVYPTLRYTATGGKIISEKGVGTLLSVTASLKQCIKQFRKLLFIKGDRDPDPQPCFRMFHATQAHTNNQMNKFLTTIAEWYRFADNRKKIVNFCSYIIRGSLAKLYAAKYKLRSRAKVYKFANRNLSLPLLQKKGQSPEYQNLLRMGLAESVDGLVYTRMSLVPETDYSPFPGNWRPEHEKFLIEYLTLDEPKTLEEQKRFIREKGLVSPQDYTSMLVWNYKRNAIPMDQVSILKDQPFLLGSSSTYNRDNDDQKNKEEDEDSEDGLRIARM
What is the function of this protein?
Nuclear-encoded maturase required for splicing of group-II introns in mitochondria.  Involved in the splicing of mitochondrial COX2, NAD1 and NAD7 transcripts (PubMed:19946041).  Necessary for mitochondrial biogenesis during early developmental stages (PubMed:22429648).
What are the official names of this protein?
Nuclear intron maturase 2, mitochondrial, AtnMat2, Nuclear intron maturase 1 b, AtnMat1b.
What is the protein family that this protein belongs to?
Belongs to the plant nuclear intron maturase (nMat) family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CC167_HUMAN
Sequence: MTKKKRENLGVALEIDGLEEKLSQCRRDLEAVNSRLHSRELSPEARRSLEKEKNSLMNKASNYEKELKFLRQENRKNMLLSVAIFILLTLVYAYWTM
What are the official names of this protein?
Coiled-coil domain-containing protein 167.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ALDA_STAAN
Sequence: MAVNVRDYIAENYGLFINGEFVKGSSDETIEVTNPATGETLSHITRAKDKDVDHAVKVAQEAFESWSLTSKSERAQMLRDIGDKLMAQKDKIAMIETLNNGKPIRETTAIDIPFAARHFHYFASVIETEEGTVNDIDKDTMSIVRHEPIGVVGAVVAWNFPMLLAAWKIAPAIAAGNTIVIQPSSSTPLSLLEVAKIFQEVLPKGVVNILTGKGSESGNAIFNHDGVDKLSFTGSTDVGYQVAEAAAKHLVPATLELGGKSANIILDDANLDLAVEGIQLGILFNQGEVCSAGSRLLVHEKIYDQLVPRLQEAFSNIKVGDPQDEATQMGSQTGKDQLDKIQSYIDAAKESDAQILAGGHRLTENGLDKGFFFEPTLIAVPDNHHKLAQEEIFGPVLTVIKVKDDQEAIDIANDSEYGLAGGVFSQNITRALNIAKAVRTGRIWINTYNQVPEGAPFGGYKKSGIGRETYKGALSNYQQVKNIYIDTSNALKGLY
What are the official names of this protein?
Putative aldehyde dehydrogenase AldA.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: FTSB_XANOR
Sequence: MRNWRWLLLVLAVLLAWLQYRFWFGPGNSGEVMMLEAQVAHQTQDNEGLRQRNQALAAEVKDLKDGEAAIEERARSELGMIKPGETFYRVVEDAPLPAPASPETAAPAQQAPASTDPVDHP
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: RS11_XANCP
Sequence: MAKPAEKKTKKKIKRVITDGVAHVHASFNNTIVTITDRQGNALSWATSGGAGFRGSRKSTPFAAQVAAEKAGRAALDYGVKSLEVRIKGPGPGRESAVRSLNNVGYKITNIIDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ARK72_MOUSE
Sequence: MLRAASRAVGRAAVRSAQRSGTSVGRPLAMSRPPPPRAASGAPLRPATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQSENILGGLGLGLGSGDCTVKIATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLHAPDHSTPVEETLRACHQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVEAELLPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNNWAETYRNRFWKEHHFEAIALVEKALQTTYGTNAPRMTSAALRWMYHHSQLQGTRGDAVILGMSSLEQLEQNLAATEEGPLEPAVVEAFDQAWNMVAHECPNYFR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate.  May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB).  Has broad substrate specificity.  Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol.  May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).
What are the official names of this protein?
Aflatoxin B1 aldehyde reductase member 2, Succinic semialdehyde reductase, SSA reductase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasm.
Protein: TIM8B_MOUSE
Sequence: MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGSRLDSRTENCLSSCVDRFIDTTLAITGRFAQIVQKGGQ
What is the function of this protein?
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim8 B, Deafness dystonia protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: SIRC_BACSU
Sequence: MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVEPEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSDAELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRRKK
What is the function of this protein?
Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin which is used as a precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis.
What are the official names of this protein?
Precorrin-2 dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
Protein: MCLN3_MOUSE
Sequence: MANPEVLVSSCRARQDESPCTFHPSSSPSEQLLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSEVYDQIIFAVTQYLQLQNISVGNHAYENKGTKQSAMAICQHFYRQGTICPGNDTFDIDPEVETECFLVEPDEASHLGTPGENKLNLSLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIKECKDWHVSGSIQKNTHYMMIFDAFVILTCLASLVLCARSVIRGLQLQQEFVNFFLLHYKKEVSASDQMEFINGWYIMIIISDILTIVGSVLKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVMRFCCCAAMIYLGYCFCGWIVLGPYHEKFRSLNRVSECLFSLINGDDMFSTFAKMQQKSYLVWLFSRVYLYSFISLFIYMILSLFIALITDTYETIKHYQQDGFPETELRKFIAECKDLPNSGKYRLEDDPPGSLLCCCKK
What is the function of this protein?
Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events.  Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:17989217).  Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity).  Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells.  Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (PubMed:18801844).  Involved in the regulation of autophagy.  Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (PubMed:24269818).  Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events.  Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity).
What are the official names of this protein?
Mucolipin-3, Transient receptor potential channel mucolipin 3, TRPML3.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily.
What are the subcellular locations of this protein?
Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cell projection, stereocilium membrane; Multi-pass membrane protein. Note=Recycles between the plasma membrane and intracellular compartments by a dynamin-dependent endocytic pathway (By similarity). In the cochlea located at the base of stereocilia near the position of the ankle links.
Protein: SECB_NITEU
Sequence: MTESQQQPVFVIEKIYVKDLSLEIPHAPRIFLEREAPEINFQLATSHNAVDGEIHEVVVTATVTARLKEKDQVMFLVEAHQTGIFRIGNVPGDEVEPVLSVLCPNILFPYLRETISDTVTRAGFPPVILNPVNFEAIYHQKKQQETAGEQPDQPADTITRH
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_HALHL
Sequence: MDNQYQPKEIEAEAQAYWEQQQTFQAREDSARPKYYCLSMFPYPSGRLHMGHVRNYTIGDVVSRYKRMQGYNVLQPMGWDAFGLPAENAAMERGVPPAAWTRENIGAMREQLKGLGFGYDWSRELATCDPEYYRWEQWLFIRLYRKGLVYRDTAAVNWDPVDQTVLANEQVIEGRGWRSGALVERREIPQWFLRITDYADELLEALDELDGWPEQVRNMQRNWIGRSEGVELSFDLAGRDEQLTVFTTRPDTLYGVTYMGLAPEHPISLELAEHHPAIAELVEEARSGGTAEADLATREKRGADTGLEAIHPLTGERIPVWVANFVLMEYGSGAVMAVPAHDQRDWEFASTYGLPIRPVVHPADGTELDIAAGAFSDYGVLADSGPFSGMPSDRAFAAIAERLEAEGRGQRRVQYRLRDWGVSRQRYWGAPIPMIHCADCGPVPVPDDQLPVTLPEDVEISGGGSPLKSMPAFYQTACPQCGADAERETDTFDTFMESSWYFARFACADQDGAMLDERADHWTPVDQYIGGIEHAVLHLLYARFYHKVLRDEGLVSSDEPFTRLLTQGMVLKDGTKMSKSKGNTVDPQELVDRFGADTVRLFTMFAAPPDQSLEWSDSGVEGAYRFLRRLHGLVRDHVAAGPAPALDPQALSDTQRDLRRKVHETIAKASDDVGKRLTFNTAIAAVMELCNALGKAQDDSAAGRAVMQEGLEAAVLILAPITPHLCHHLWFQLGHTAPVVEAPWPEADKQALVRDEVELVVQVNGKLRGHVTLPADADQQQAQEAALAEHNVQRFVADKEIKKVVFVPGKLINVVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCME_CUPPJ
Sequence: MTPRQRRLGMLLAALACAGIALALVLNAFRSNLVFFFSPSQVAAHEAPASRSFRLGGLVAPGSIRREGDGMTVRFIVTDKAREVPVVYRGLLPDLFREGKGVVARGTLDRSGTFVASEVLAKHDENYMPPEAADALKQAEQVNRRMASQLAEGERETQR
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: RS5_PROM1
Sequence: MTDSNNQSPNKKTSGSSGAPTAADGRQENRRSRGEKRGGRRDRRGQERDSEWQERVVQIRRVSKTVKGGKKMSFRAIVVVGNEKGQVGVGVGKAGDVIGAVRKGVADGKKHLVRVPLTRNSSIPTLSNGRDGAASVLIRPAAPGTGVIAGGSIRTVLELAGIKNVLAKRLGSKTPLNNARAAMVALSELRTHKATAKERGISLEQIYS
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: CCD32_MOUSE
Sequence: MKMFESLDSSATKSGRDLWAEICSCLPSPAQEDVSDNAFSDSFMDSHPAGESHTAAADSAVQPAGKPWAPLHDSEVYLASLEKKLRRIKGLNEEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDERTLEHFKRWLQPDKVAISTEEVQFLIPPESQAEKPEAGDKPAAAEQ
What is the function of this protein?
Has a role in ciliogenesis (PubMed:32307552).  Required for proper cephalic and left/right axis development (By similarity).
What are the official names of this protein?
Coiled-coil domain-containing protein 32.
Protein: HRCA_BACSU
Sequence: MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRNEMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFELEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVENKTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDALRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGISIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLSKALTSLYDE
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: RSMC_SHEON
Sequence: MLTNPSQVIIRNQETLSQHKVLVLNHEADLLPKALLDVASSVDALALDYHHYLHLAPQANNKLRCYFGHQLPHQNKYNTVIVYFPKAKPLAPYLFNLAAQHLVPNGQLLVVGENKGGIKSLVKLLPNYFAAGVKLDNARHSLLFGSSLIDTAPEITLSDWASQYQLSTPQGNITICNLVGVFSEKHLDQGTELLLSHLPTLSGRVLDFGCGAGVIAATLLKAQPTLSLECIDINAMALASCELTLAANGMMAKVYPSDGLAQTSGKFDGIISNPPFHDGLASTTNIAQRFVADSAKQLQSKGIWQIVANRHLPYSDTIAAEFGQLTVPAENNKYKLYYFQQS
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.