PharMolix/UniProtQA huggingface dataset:
Protein: VM32_BOTAT
Sequence: EQQRYLNAKKYVKLVLVADYIMYLKYGRSLTTLRTRMYDIVNIINLIFQRMNIHVALVGLEIWSNRDKIIVQSSADVTLDLFAKWRETDLLKRKSHDNAQLLTGINFNGPTAGLAYLSGICKPMYSAGIVQDHNKVHHLVAIAMAHEMGHNLGMDHDKDTCTCGARSCVMAGTLSCEPSYLFSDCSRRGHRAFLIKDMPQCILEKPLRTDVVSPPVCGNYFVEVGEECDCGSPATCRDTCCDAATCKLRQGAQCAEGLCCDQCRFKGAGTECRAAKDECDMADLCTGRSAECTDRFQRNGQPCQNNNGYCYNGTCPIMRDQCIALFGPNAAVSQDACFQFNLQGNHYGYCRKEQNTKIACEPQDVKCGRLYCFPSSPATKNPCNIHYSPNDEDKGMVLPGTKCADGKACSNGRCVDVT
What is the function of this protein?
Snake venom zinc metalloprotease that induces apoptosis in vascular endothelial cells (VEC), without degrading the extracellular matrix (it cannot cleave collagen) or inhibiting adhesion of VEC.  Has also fibrinogenolytic and hemorrhagic activities (By similarity).
What are the official names of this protein?
Zinc metalloproteinase-disintegrin-like batroxstatin-2, Snake venom metalloprotease, SVMP, Vascular apoptosis-inducing protein-like, VAP-like.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIc sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RIBBA_RHOJR
Sequence: MTRFDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMVRYTSGYLCVPLDGADCDRLGLPPMYATNQDKHGTAYTVTVDAREGIGTGISASDRAATMRLLADPSSGAQDFTRPGHVVPLRAKEGGVLRRPGHTEAAVDLARMADLRPAGVICEIVSQKDEGHMAQTDELRVFADDHNLALISIADLIAWRRKHEKHVERVASARIPTRHGEFTAVGYRSIYDDVEHVALVRGDLPGPDGDGSDVLVRVHSECLTGDVFGSLRCDCGPQLDAALDMVAQEGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGSDTVDANLELGLPADARDYGIGAQILVDLGISSMRLLTNNPAKRVGLDGYGLQITERVSMPLRANAENLTYLRTKRDRMGHDLIGLDDFEAGEML
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: SDHB_MOUSE
Sequence: MAATVGVSLKRGFPAAVLGRVGLQFQACRGAQTAAAAAPRIKKFAIYRWDPDKTGDKPRMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLSKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSVYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA
What is the function of this protein?
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Iron-sulfur subunit of complex II, Ip.
What is the protein family that this protein belongs to?
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: MBP2C_TOBAC
Sequence: MYKPQQQQQLFDLQDNNGAAFDNGGTDPSCWLSHENEISRTDSSLSSSNVDPLLFNDLVQIVPLVQSLIDRKEKSSFTRRGSMTYTKMPSRESLYKKTSEVKGRNAGQSTATKKHRDQNKNVSSSQDGYAENFSTPSSTSSLTEKDREELMTLREKVEDLQKKLLEKDELLKEAEILKNEITATNAELDEMKKDISEKDFLVKTTQVQLSDALVKLADKKAAVEKLEWEAMTSSKKVERLQEDLDLLQGEISSFIQFVHALTGNDSRDSAEECNVIPYPWDQNVEIDKLNERDLQKMEAAREAYIAAVAAAKENPDEASLSAASTARSYLQSLVLRT
What is the function of this protein?
Prevents homeodomain proteins (e. g.  STM) association to plasmodesmata and, consequently, cell-to-cell transport.  Binds to RNA.  Alters KN1 RNA-binding capacity (PubMed:17965274).  Regulates cytoskeleton (e. g.  actin) organization that determinates cell shape (By similarity).  Interferes with cell-to-cell transport of tobacco mosaic virus movement protein (TMV-MP) by mediating its accumulation at microtubules, thus interfering with cell-to-cell virus movement.
What are the official names of this protein?
Protein MICROTUBULE BINDING PROTEIN 2C, NtMBP2C, Movement protein binding protein 2C, TMV-MP30 binding protein 2C.
What is the protein family that this protein belongs to?
Belongs to the microtubule binding protein 2C family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Microtubule-associated (PubMed:12913144). Localized in cytosolic punctae when associated with KN-1 (PubMed:17965274).
Protein: DSBD_SALPA
Sequence: MAQRIFTLILLLCSTSAFAGLFDAPGRSQFVPADRAFVFDFQQNQHDLTLSWQVKEGYYLYRKQISITPTKADIAAVQLPAGVWHEDEFYGKSEIYRKRLNVPVTVNQAAAGATLTVTYQGCADAGFCYPPETKTVPLSEVAAAIDATPTPAVTQTGETSKPAAQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGRQRLSTGRALLLAFIYVQGMALTYTALGLVVAAAGLQFQAALQHPYVLIGLAIVFTLLALSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFVMGAIAGLICSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLVTVFGNRLLPKSGPWMAHVKTAFGFVILALPVFLLERIIGEAWGLRLWSLLGVAFFGWAFITSLQARRAWMRIVQIILLAAALISVRPLQDWAFGSPSAQAPAHLNFTAISTVDELNQALAQAKGKPVMLDFYADWCVACKEFEKYTFSDPRVQQALGDTVLLQANVTANNAQDVALLKHLQVLGLPTILFFDAQGQEQPQARVTGFMDAATFSAHLHDRQP
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y3073_STRGG
Sequence: MSDSKLAGQFFDAAIGLLTRVRDEESDSIAAAGAAVADTVASGGRLFAFGAGHSSLAAQDVVYRAGGLALMNLLTVPGAVGVDVMPATLGSALERVDGLASAVLDSSPATAGDLLVIVSLSGRNALPVEMAQNARALGLKVIGLTSVAYAENTRSRHASGGFLRDHCDIVLDSKIAIGDAELTAPGVEAPFAPASTVVTSAIMQAMLAAAVEQLVARGIEPPMLRSGNVDGGHEWNGRVMTEYRDRIFYRH
What are the official names of this protein?
UPF0309 protein SGR_3073.
What is the protein family that this protein belongs to?
Belongs to the UPF0309 family.
Protein: PSB_MYCPA
Sequence: MTWQFPDRLSTNSALPGPAFSGQPAVDLSSFADFLRRQAPELLPAALGGAQSGPASSSGGTGQLPHGTTIVALKYPGGVVLAGDRRSTQGNMIAGRDVKKVYITDDYTATGIAGTAAIAVEFARLYAVELEHYEKLEGVPLTFAGKVNRLAIMVRGNLAAAMQGLVALPLLAGYDIDAPDPEGAGRIVSFDAAGGWNLEEEGYQSVGSGSIFAKSSMKKLYSQVVDADSAVRVAIEALYDAADDDSATGGPDLVRGIYPTAVTIGAEGALEVPESRIAELAREVIQSRSRADTFGPDAAGGDK
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PrcB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TEG1_HHV11
Sequence: MQRRTRGASSLRLARCLTPANLIRGDNAGVPERRIFGGCLLPTPEGLLSAAVGALRQRSDDAQPAFLTCTDRSVRLAARQHNTVPESLIVDGLASDPHYEYIRHYASAATQALGEVELPGGQLSRAILTQYWKYLQTVVPSGLDVPEDPVGDCDPSLHVLLRPTLAPKLLARTPFKSGAVAAKYAATVAGLRDALHRIQQYMFFMRPADPSRPSTDTALRLNELLAYVSVLYRWASWMLWTTDKHVCHRLSPSNRRFLPLGGSPEAPAETFARHLDRGPSGTTGSMQCMALRAAVSDVLGHLTRLANLWQTGKRSGGTYGTVDTVVSTVEVLSIVHHHAQYIINATLTGYGVWATDSLNNEYLRAAVDSQERFCRTTAPLFPTMTAPSWARMELSIKAWFGAALAADLLRNGAPSLHYESILRLVASRRTTWSAGPPPDDMASGPGGHRAGGGTCREKIQRARRDNEPPPLPRPRLHSTPASTRRFRRRRADGAGPPLPDANDPVAEPPAAATQPATYYTHMGEVPPRLPARNVAGPDRRPPAATCPLLVRRASLGSLDRPRVWGPAPEGEPDQMEATYLTADDDDDDARRKATHAASARERHAPYEDDESIYETVSEDGGRVYEEIPWMRVYENVCVNTANAAPASPYIEAENPLYDWGGSALFSPPGRTGPPPPPLSPSPVLARHRANALTNDGPTNVAALSALLTKLKREGRRSR
What is the function of this protein?
Plays a role in the activation of the host PI3K/AKT pathway to promote cell survival.  Interacts with and activates host LCK and thereby recruits downstream partners SHC1, GRB2 and PI3KR1 in order to activate the PI3K pathway by phosphorylating host AKT on its activating residues.  This mechanism is inhibited by the viral protein US3 that instead promotes incorporation of UL46 into virions.  Plays a role in the inhibition of TMEM173/STING-mediated type I interferon production (PubMed:28592536).  Interacts with host DOK2 and induces its degradation.  This immune evasion mechanism to inactivate T-cells may play an important role during pathogenesis (PubMed:28841444).
What are the official names of this protein?
Tegument protein UL46, Tegument protein VP11/12.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HHV-1 VP11/12 protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host cell membrane; Peripheral membrane protein.
Protein: THIC_NITMU
Sequence: MNATVSSAVQSSLPFSGKTAQVDEGTVKPLPRSQKTYLSGSRPDIRVPMREISQSDTPASMGAEKNPPIYVYDTSGPYTDPAIKIDIRAGLAPLREKWIDERGDTEILSGPASIYGRQRLNDPRLAELRFDLKRSPRRARAGANVTQMHYARGGIVTPEMEFIAIRENQRCEHLADQQREMLARQHPGQDFGAFLPRHITPEFVRDEVARGRAIIPANINHPESEPMIIGRNFLVKINANIGNSALSSSIQEEVEKMTWAIRWGGDTVMDLSTGKNIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLAYVPMTAKRLTGIVSRGGSIMAKWCLAHHKESFLYTQFEEICEIMKAYDVSFSLGDGLRPGSIYDANDEAQFAELKTLGELTQIAWKHDVQVMIEGPGHVPMHLIKENMDMQLKYCAEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAMLCYVTPKEHLGLPDKDDVKDGIITYKIAAHAADLAKGHPGAQLRDNALSKARFEFRWEDQFNLGLDPDKARQFHDETLPQEGAKLAHFCSMCGPHFCSMKITQDVRDFAASKGVSDQEALEKGMEEKASEFVARGTEIYSKV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: MOBA_BURA4
Sequence: MSASPSPSITGLLLAGGRATRMDGADKGLQLLDGTPLALHVLRRLSPQVDETLISANRNADRYAELGAPFDARIVADETADFPGPLAGLLAGMRAARAPLVACAPCDTPYLPADLIARLHAALDAQQADIAMAVTVDAQHARSPQPTFALLRTSLADDLAAALAAGERKVRAWYARHKTVEVEFRDERAFYNANSWHELAALARR
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XRP2_HUMAN
Sequence: MGCFFSKRRKADKESRPENEEERPKQYSWDQREKVDPKDYMFSGLKDETVGRLPGTVAGQQFLIQDCENCNIYIFDHSATVTIDDCTNCIIFLGPVKGSVFFRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSSNIKFGCFQWYYPELAFQFKDAGLSIFNNTWSNIHDFTPVSGELNWSLLPEDAVVQDYVPIPTTEELKAVRVSTEANRSIVPISRGQRQKSSDESCLVVLFAGDYTIANARKLIDEMVGKGFFLVQTKEVSMKAEDAQRVFREKAPDFLPLLNKGPVIALEFNGDGAVEVCQLIVNEIFNGTKMFVSESKETASGDVDSFYNFADIQMGI
What is the function of this protein?
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane.  Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B).  Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.  Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
What are the official names of this protein?
Protein XRP2.
What is the protein family that this protein belongs to?
Belongs to the TBCC family.
Protein: QUEA_BURPS
Sequence: MLTLSDFDFDLPPELIAQTALPERSASRLLEVDNTNPSAPPRLVDRRFAELPACVAPGDLLVFNDTKVLKARFFGRKASGGKIEVLIERVTGERTALAQIRASKSPPPGTTLTLADAFDVTVGERVEPFFTLHFPDDCLVLIERHGRLPLPPYIEHAPDAADETRYQTVFAANPGAVAAPTAGLHFDDAVLTALEARGVERATLTLHVGAGTFQPVRVENLAEHRMHSESYELTDALVEKIAATRARGGRVIAVGTTSMRALEAAARDAQAAGRPLAATRAETDIFITPGYRFRVVDRLVTNFHLPKSTLLMLVSAFAGIETIRAAYRHAIDARYRFFSYGDAMLLTRRDDAAEATHGGA
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_PROM9
Sequence: MKNRFNSEDKIILAIDGLDLNQAKLLLEKCPSIKWVKVGLELFVREGPRVVEILKGLNKKIFLDLKFHDIPNTMSAACFQVSKLGVDIISVHSSAGLKALQDSKKASLEGASLANLKPPFVVGITVLTSFSLKDFQTDLDRKNSIEDNVLRLAKLSFDAELDGCVCSPWEVKMLRSIYKNNFELITPGIRLKIDNKDDQNRIMTPNEAIDNGASKLVIGRSISKALDPNKALIEIFKSIDSD
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: MENC_SALPC
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLRDGEREGWGEISPLPGFSQETWEEAQTALLTWVNDWLQGSEGLPEMPSVAFGASCALAELTGVLPEAADYRAAPLCTGDPDDLVLRLADMPGEKIAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKAQQFAKYVNPDYRARIAFLEEPCKTRDDSRGFARETGIAIAWDESLREADFTFEAEEGVRAVVIKPTLTGSLDKVREQVAAAHALGLTAVISSSIESSLGLTQLARIAAWLTPGTLPGLDTLHLMQAQQIRPWPGSALPCLKREELERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: DXS_PORGI
Sequence: MMEVRPTTLIDHINSPADLRALKPEQLPQVCRELRRYILEVLSVTPGHLGSSLGAVDFTVALHYVFDTPYDRIVWDVGHQAYSHKILTGRREDFRHLRQWGGISGFPSPKESEYDTFPAGHASNSISAALGMAVASAAKDEKRKVIAVIGDGSMTGGMAFEGLNNASSFPNNLLIILNDNNMSIDRNVGGLNRYMVDILTSKTYNTIRYDLYKGLRKINLISETNRKNLLRFNNSFKALLARESNLFEGFSIRYFGPVDGNNVLRLVEVLNQIKDMAGPKILHLRTIKGKGYSPAEKQATIWHAPGEFDIKSGERKKGENKPEPPKFQDVFGHTLVELADRDERVVGVTPAMPTGCSMTFLMKKYPNRAYDVGIAEGHAVTFSAGLAKEGLIPFCNIYSSFIQRGYDQVIHDVALSGSHVVICLDRAGLVGEDGATHHGVFDMAFLRCVPDIVVASPLNEHELRNLMLTAYKGYDGPMVIRYPRGKGVLTDWRNTPRLVEIARGRCLTEGEAIAFLSIGPIGNMVQKVVERLAEKGVSAAHYDMVFLKPLDEEMLHGIAKKFDTIISVEDGCIQGGFGSAVMEFMADHDYHPRIRRVGVPDRFIGQGSVPEQYADCGMDADSLLHLTEELLLHP
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: S35G2_HUMAN
Sequence: MDTSPSRKYPVKKRVKIHPNTVMVKYTSHYPQPGDDGYEEINEGYGNFMEENPKKGLLSEMKKKGRAFFGTMDTLPPPTEDPMINEIGQFQSFAEKNIFQSRKMWIVLFGSALAHGCVALITRLVSDRSKVPSLELIFIRSVFQVLSVLVVCYYQEAPFGPSGYRLRLFFYGVCNVISITCAYTSFSIVPPSNGTTMWRATTTVFSAILAFLLVDEKMAYVDMATVVCSILGVCLVMIPNIVDEDNSLLNAWKEAFGYTMTVMAGLTTALSMIVYRSIKEKISMWTALFTFGWTGTIWGISTMFILQEPIIPLDGETWSYLIAICVCSTAAFLGVYYALDKFHPALVSTVQHLEIVVAMVLQLLVLHIFPSIYDVFGGVIIMISVFVLAGYKLYWRNLRKQDYQEILDSPIK
What is the function of this protein?
May play a role in cell proliferation.
What are the official names of this protein?
Solute carrier family 35 member G2, Transmembrane protein 22.
What is the protein family that this protein belongs to?
Belongs to the SLC35G solute transporter family.
Protein: RL20_PHOV8
Sequence: MPRSVNHVASRARRKKILGLTKGYFGARKNVWTVAKNTWEKGLTYAYRDRKNKKRNFRALWIQRINAAARLEGMSYSKLMGALHKAGIEINRKVLADLAMNHPEAFKAIVAKAKAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: MUTH_YERE8
Sequence: MSVYSLPPAPPTDEHQLFQRAEALSGFTLGELASKAGWNIPADLKRIKGWVGMLLEFYLGASAGSKPEQDFADIGIELKTIPISAQGKPLETTFVCVAPLTGNSGITWESSHVRHKLARVLWVPVEGERQIPLAQRRVGAPLLWSPNEEEEELLRRDWEELMDLIVLGKVETITARHGEVLQLRPKAANSRALTEAIGEHGQPIMTLPRGFYLKKTFTGPMLARHFLL
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C25L2_DANRE
Sequence: MLDISNTTWDLSNQSVLQPLWDYLQQNHESSLRSPLFPVILSVSMYLVLVFFYTVLDLLAPTWPSIRRYQIHQDRTVTWSNIGSTLALTTYNHLLYIFPAAVAQWLWRPPIPLPREAPTLTAFLLGIVGCTVVFDFQYYLWHLLHHRVGWLYRTFHALHHQYRQTFSLVTQYLSAWELFSVGFWTTVDPLLLQCHCLTAWAFMLFNIWVSTEDHCGYDFPWAMHRLVPFGLWGGALRHDAHHQLPGTNFAPFFAHWDWLGGTATMPAPVKTKKRDDKEA
What is the function of this protein?
May catalyze the formation of 25-hydroxycholesterol from cholesterol.
What are the official names of this protein?
Cholesterol 25-hydroxylase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL5_VESOH
Sequence: MSRLQEQYKNKISLILQKELGMSNPMQTPKIEKITINMGLGNALGDKKILQSGLEEMSLISGQKPLTCNARKSVASFKLREGNPIGCKVTLRKQKMYEFLDRLVNITIPRIRDFRGLKTTAFDGRGNYNMGITEQITFPEIDFEKVTKIRGMDIAITTTAKSDEDAKKLLAMFKFPFKG
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: DHAM_PANAM
Sequence: MVNLVIVSHSAMLGEGVEMLARQMLTGDNCRIAVAAGIDDPDHPIGTDPIKVMEAIEAVADTDHVLVMMDMGSALLSAETALDLLDPVIAEKVRLCAAPLVEGTLAATVSAAAGADIDTVIDVAMNALAAKQAQLGITPPAHAASLPAQAPDSDARSVTVTIRNHHGLHVRPASRLVAALAGMNADLVLEKQGQCVKPDSLNQIALLQVRCHDAVTLSASGPDAERALAAFESLAAEDFGEHPESMALKTSASTVEKVQGKAVFYPLPLAQPARHPCSDVGQEERRLQQAIVDTLNDLNALAALAEKKYGASVAAIFSGHYTLLDDPDLFDAACKVIRNDSCCAESAWYQVLMELSQQYQHLDDAYLQARFIDIEDILYRSLCHLKGRDIRLPTPDVPAIIVADDIFPSAVVNLNAQLVKGICLREGSTLSHAAIIAQQAGIAFICQQGAVLDIIQPEDRLLIDPAAQRVSCA
What is the function of this protein?
Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone.  DhaM serves as the phosphoryl donor.  Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
What are the official names of this protein?
PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM, Dihydroxyacetone kinase subunit M.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
Protein: RNH3_STRZT
Sequence: MASITLTPSEKDIQAFLEHYQTSLAPSKNPYIRYFLKLPQATVSIYTSGKILLQGEGAEKYASFFGYQAVEQTSGQNLPLIGTDEVGNGSYFGGLAVVAAFVTPDQHDFLRKLGVGDSKTLTDQKIRQIAPILKEKIQHQALLLSPSKYNEVIGNRYNAVSVKVALHNQAIYLLLQKGVQPEKIVIDAFTSAKNYDKYLAQETNRFSNPISLEEKAEGKYLAVAVSSVIARDLFLENLENLGRELGYQLPSGAGTASDKVASQILQAYGMQGLNFCAKLHFKNTEKAKKRLER
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_POLAQ
Sequence: MSIVDNKKAFFDYFIEERFEAGLVLEGWEVKAIRAGRVHVKEAYVVIRKAELFLIGCHITPLLSASTHIVPDSTRTRKLLLNAIEIRKLIGKVEQKGYTLVPLNLHFTKGNVKCEIGLARGKKQHDKRAATKEREWEVQKGRIARGDLNA
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MURC_NOCSJ
Sequence: MRLPVPDQVLPADRLGRVHFVGIGGAGLSGIARIMLARGITVSGSDGTDSPTLTALRELGARVHLGHDAAHVHDVDTLVVSTAVREDNPEYVEAVRQGLRVLPRSAALAAVMAGRRVVAVAGTHGKTTTTSLLTVALQAAGADPTYAIGGDLAATGVNAAEGTGDLFVAEADESDGAFLHYSPYAAVVTNIEADHLDQWGTPEAYAAAFDEFADTLAPDGFLVCVADDPGAAALAERHRAAGRRVVTVSARDAGALDGVTLWSPGEHYLADALAALAAGVELGYAAADLARGLASYTGTKRRMERKGEAGGVRVYDSYAHHPTEIAGDLQAARAVAGSGRVVVAFQPHLVSRTRIFGTAMGRALGAADEVVVLDVYLAREDPDPEVTGALVAGAVPLPAERVAYVADFDAVAAELVARARPGDLVLTLGAGTVTAIGPRVLGLLDG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIO_HUMAN
Sequence: MSGTKPDILWAPHHVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLLSINSDTPYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVKLSAGETETTLLVTKPLYELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECTEEENDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDMDQKSPGNKGSLVYAGIKSIVKSSLGMVESSRHNWSGLDKQSDIQNLNEERILALQLCGWIKKGTDVDVGPFLNSLVQEGEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGYTDEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSETGSYDGVLYENKVAVRDRVAFACKFLSDTQLNRYIEKLTNEMKEAGNLEGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSAVPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLINMGTPVSSCPGGTKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTCKCMQLDTTGNLVPAETVQP
What is the function of this protein?
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway.  Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).  It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
What are the official names of this protein?
GATOR complex protein MIOS, Missing oocyte meiosis regulator homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat mio family.
What are the subcellular locations of this protein?
Lysosome membrane.