PharMolix/UniProtQA huggingface dataset:
Protein: Y2732_PAEAT
Sequence: MSRPASSNPPGRSPLRRGALTPTLIVVAVAVVGFIFFANVWTDVLWYQQLGFFEVYIRENLARIITFLIGFAMMFAAVFFAIRIAYRSRPVYAPDAEARDNLNRYQAQLEPVRRVVMIGLPILFGLFAGSAAASQWQKALLFFNQEPFGQADPLFNMDISFYLMSLPFLGFITGFLISIAVVAGIAGILTHYLYGSIRLMERGIFTSRAAQIHIAVTGALFLILLGVNFWLDRYTTVQSNSGRWAGALYTDVNAVVPTKAILAVAAGLVAILFIIAAIIGRWRLPVIGTAMLVITAILAGGVYPWVIQQFQVRPSENTLEKEFIDRNIKMTRAAYGLDKIDVSAYNATTTATTGALAADAQTTANIRLLDPNLISSAFAQLEQYRPYYQFPQTLNVDRYMVDGKVQDTVIAVRELNPDGLSANQQTWVNRHIVYTHGYGVVAAKGNKFTADGKPEFLQSGIPSNGVLGNDTSYEPRIYFGENSPEYSIVGAPDGAPNREQDRPAGREGGGETQYTFSGNGGPNVGNWLNRILYSIKFQSSDLLLSDGVNAESQILYERNPRERVEKLAPYLTVDGNAYPAVVDGRVKWIVDGYTTSQYFPYSQPQQLQNATVDSQTSAGRTVALPNSSVNYIRNSVKATVDAYDGSVNLYAWDDQDPILKAWQKVFPTVIKPYSEMSGDLMSHVRYPEDLFKVQRELLGRYHVTDPDSFYQNNDAWSVPNDPTVSEAVKQPPFYMSLQMPDQEKPAFQLTSSFIPQTVNGSARNILYGFLAADSDAGNVKGVKGESYGKLRLLELPTDTQVPGPGQAQNKFNSDPTVSQALNLLRQGASDVLNGNLLTLPVGGGLLYVQPVYLKSTGETSYPTLQRVLVAFGDKIGFAPTLDEALDQLFGGDSGATAGDSDNNGQTPTSPPGTTPPPAGPTDAKADLKAALDEANKAIQDGQAALAKGDFAGYGAQQTKLSEALKKAIDAQARLDATPAPTATPGATPSATPSPSPSS
What are the official names of this protein?
UPF0182 protein AAur_2732.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2221_YERPA
Sequence: MQIWVDADACPNVIKEVLFRAADRTGMMVTLVANQPLKTPPSKFIRTVQVASGFDVADNEIVQRVEKNDLVITADIPLAAEVIEKGGIALNPRGERYTPDTIRERLNMRDFMDTMRASGIQTGGPNTLNQRDRQQFANELDKWLQQARNQAK
What are the official names of this protein?
UPF0178 protein YPA_2221.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: ACT1_SOLTU
Sequence: AGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILSLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDHLMKILTERGYSFTTTAEREIVRDVKEKLSYIALDYEQEMIDSTVEKTYELPDGQVITIGAERFRCPEVLFQPSIIGMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTTMFPGIADRMSKEITALAPCSMKIKVVAPPERKYSVWIGGSILASLSTFQQ
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.
What are the official names of this protein?
Actin-42.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ATG12_CRYNB
Sequence: MATTTPPLDRLSPAQAQPAVVVRFKSIGSAPIMKNNVFKATAGHKFQAVIMFLRQQLGMKKEDSLFTYINAAFAPAPDDTVGSLYKSFGTEGHLIVNYSNTQAWG
What is the function of this protein?
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.  Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function.  The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Ubiquitin-like protein ATG12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: YIDC_XANOM
Sequence: MNQTRVFLIFAWLMVAALLWMEWGKEKAAANAPGAAATQSVPAARDLDAATPSAANVPAAQPIAQAGAPGTVPATSTTTATATATPAAAGAAPVVTLTSDVLRLKLDGRSVLDAELLQFPQTKDGTAPVSLLTEDAAHPYNATSGWASEHSPVPGVGGFRAEQPGTTFELAKGQNTLVVPFVWNGPNGVSIRRTFTLERGRYAISIKDEVINKSAAPWNGYVFRKLSRVPTILSRGMTNPDSFSFNGATWYSPQAGYERRAFKDYMDDGGLNRQITGGWIALLQHHFFTAWIPQNDQASLYVLNKDGPRDVAELRGPAFTVAPGQTATTEARLWVGPKLVSLIAKEDVKGLDRVIDYSRFSIMAIIGQGLFWVLSHLHSFLHNWGWAIVGLVVLLRLVLYPLSSAQYKSSAKMRKFQPRLAQLKERYGDDRVKYQQATMELFKKEKINPMGGCLPLLIQMPIFFALYWVLVESVELRQAPWLGWIQDLTARDPHFILPALNIAIMWATQKLTPTPGIDPMQAKMMQFMPLVFGAMMAFVPSGLVLYWVVNGGLNLLIQWWMIRQHGEKPSKIIRANAK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CTL1_TORMA
Sequence: MGCCGCGSEEGSVRQWKPLEQRSCTDVLWLLIFVLFCIGMAIICGFAIASGAAQRLVFGYDSYGNICGHKNTEIKDVTMSGLDHTDKKYVFFFEPCNWDMVHLKILSVALCVTKCPDMDLKTLEDVRNFAKYNGSRLCLYNLDPTQYTSKNSKSCPILPVKSSKPIPFFHRCVPMDSGCKINFKALTTFVSYNSVLQRVITGVMTSKEIIVGLCLMSLVLSILLMVIIRYISKVLVWILAILTIIGSIGGTAVLWWLYADHKKTLKLDPSQGDVAADNVTALLVCAIIATVITVILLLLMLIMRKRVALTIALFHVAGKVFIHIPFLIFQSLWTFLALAFFWIYWIAVLLLLATAGYPQKKDQGYVEFKVSGPLQYTWIYHLVGLIWISEFILACQQMTIAGAVVTYYFTRDKHNLPATPILASMCRLIKYHLGTVAKGSFIITLIKIPQMILVYIHSQLKGKENACAKCMLKACMCCLWCLEKCLLYLNRNAYIATSINGTSFCTSAKDAIVILVENAMRVAAINTVGDFVLFLGKLLIVLVTGFVGIILLNYQRDYTVWVLPLIIICLFAFFVSHCFLSIYEMVVDVLFLCFAVDCKHNDGSPGREYYMDKSLMEFMDESRKAMRSVTGSGAEMKSMASGSDNA
What is the function of this protein?
Probable choline transporter.  May be involved in membrane synthesis and myelin production.
What are the official names of this protein?
Choline transporter-like protein 1, Solute carrier family 44 member 1.
What is the protein family that this protein belongs to?
Belongs to the CTL (choline transporter-like) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: YQGF_PROM5
Sequence: MKYSKPKSKSILSLDIGTKRIGLAYCDSLFITVNILPALRREKNKNEFKTIKSHIKKLNLTGFIVGLPLDDKGRMTSQAFDCKTYGEYLFNELKLPFSFVNEHSSTWESENRFGVKKDKSGLIDSLSAKVILEQWIQEGPELKELMGNKQI
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEGS_SALTY
Sequence: MANFPASLLILNGKSADNQPLREAITLLRDEGIQIHVRVTWEKGDAQRYVDEARRLGVETVIAGGGDGTINEVSTALIQIRDGVAPALGLLPLGTANDFATSAGIPEALDKALKLAIAGNAMEIDMAMVNDKTCFINMATGGFGTRITTETPEKLKAALGGVSYLIHGLMRMDTLTPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPTALINDGLLQLRIFTGEELLPALFSTLTQSDDNPNIIDGASAWFDIHAPHEITFNLDGEPLSGQEFHIEVLPGALRCRLPPDCPLLR
What is the function of this protein?
In vitro does not phosphorylate diacylglycerol, sphingosine, N,N-dimethylsphingosine; threo-dihydrosphingosine, erythro-dihydrosphingosine, C2 ceramide, C6 ceramide, phosphatidylinositol or dimethylsphingosine.  The potential in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
Protein: AATC_PIG
Sequence: MAPPSVFAEVPQAQPVLVFKLIADFREDPDPRKVNLGVGAYRTDDCQPWVLPVVRKVEQRIANDSSLNHEYLPILGLAEFRTCASRLALGDDSPALQEKRVGGVQSLGGTGALRIGAEFLARWYNGTNNKDTPVYVSSPTWENHNGVFTTAGFKDIRSYRYWDTEKRGLDLQGFLSDLENAPEFSIFVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGNLEKDAWAIRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVAKEPDSILRVLSQMEKIVRVTWSNPPAQGARIVARTLSDPELFHEWTGNVKTMADRILSMRSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLINEKHIYLLPSGRINMCGLTTKNLDYVATSIHEAVTKIQ
What is the function of this protein?
Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:4634443).  Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system.  Acts as a scavenger of glutamate in brain neuroprotection.  The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis.  Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide.  Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST).  Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity).
What are the official names of this protein?
Aspartate aminotransferase, cytoplasmic, cAspAT, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2002_METTM
Sequence: MPLSLATSNRVPEAWRDLIISAMSNLAPLGRDPNTKEFTDELHHLSGEDMGTVMEILGIAVAEGFLEYDDHYRLILGPAGEEYVRLSSRVKVEETRRLTLRRALRRFRDKRRACRHLSLGDKALYDYYYHGGL
What are the official names of this protein?
Uncharacterized protein MTBMA_p00020.
Protein: RL16_SALPA
Sequence: MLQPKRTKFRKMHKGRNRGLAAGADVSFGSFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLAVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: THIM_ALIFM
Sequence: MNIQYIVECLALLREKKPLVVNITNYVVMNNTANALLALGASPIMAHSQQEMAEMMSFSGALVINIGTLDSVWTPRMHFAVEQANLNNKVVVLDPVGCGASQLRTQVARQIAEAANKLIIRANASEVIALAGENAQSKGVDALDSSDSAVGAACYVAQKYQCSVVISGETDYIVTQDAQYKLNNGHAMMPFVTGMGCTHTALTGAFAAIGDESGVVATAVLGVAGEIAAEQSAGPGSLQMNLLDTLYQLDEETLTRRLKLTVNA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: SH3L3_RAT
Sequence: MSGLRVYSTSVTGSREIKSQQSEVTRILDGKRIQYQLVDISQDNALRDEMRTLAGNPKATPPQIVNGDHYCGDYELFVEAVEQNTLQEFLKLA
What is the function of this protein?
Could act as a modulator of glutaredoxin biological activity (By similarity).  May play a role in cytoskeleton organization (By similarity).
What are the official names of this protein?
SH3 domain-binding glutamic acid-rich-like protein 3, TNF inhibitory protein B1, TIP-B1.
What is the protein family that this protein belongs to?
Belongs to the SH3BGR family.
Protein: CUT5_CAEEL
Sequence: MNFILAVFAIILLQAVRGEIDNAIVGDPSVECGDDFFEVNIYHSCSCVGNFIIKVKFDTRTTFHGLAFVQNHLDNPDCRSFASKTDSAKNSSLRLTFDQCAIEKRHSTSPRGLFLSTNVVVAFNPEFLTKNDRVFKVQCFYMEMERRIQKVIQISMPPPTMHSKQLNMPVCKYEVLDGSPTGPPVYFATVGQMVYHKWTCDTEHENTFCMLVHSCFVDDGNGQRVQLLNDKGCALDKYLLTNLEYPTDLMAGREAHVYKYADRDNMYFDCQISITVKEPGLDYCDVPSCPDPPRRRRSNTLPAPDDNITAIAAHIEYEDSEIISDYIIPNDDIISLNWLQRNFDMRISELCMTAIGTTLLVFLNAFLFIISLVSIVHVCCFRTSPKLEKTKSTML
What is the function of this protein?
Plays a role in alae formation in L1 and dauer stage larvae.
What are the official names of this protein?
Cuticlin-5.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: TPIS_DESVV
Sequence: MKKLIAANWKMYKTIDEARATGRELVSAVAGSLPADREVLVCPPFTALHALHDTFKDVEGFAIGGQDVYPATEGAYTGEIAPGMLLDAGCGWVLTGHSERRHILGEDDETVARKTAFSLKAGLRVVLCIGEKLDEREAGRLEDVLAHQLQVGLADVDATYVPQSLVVAYEPVWAIGTGKVAGPAEVVEAHALVRSLLEARYGRDGAAIRILYGGSVKPDNAAELLSLDNVDGLLVGGASLQAVSFSRIILA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACUI_ECOLI
Sequence: MQALLLEQQDGKTLASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKIIRNFPMIPGIDFAGTVRTSEDPRFHAGQEVLLTGWGVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVMALEDAGVRPQDGEIVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGASRVLPRDEFAESRPLEKQVWAGAIDTVGDKVLAKVLAQMNYGGCVAACGLAGGFTLPTTVMPFILRNVRLQGVDSVMTPPERRAQAWQRLVADLPESFYTQAAKEISLSEAPNFAEAIINNQIQGRTLVKVN
What is the function of this protein?
Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA.
What are the official names of this protein?
Probable acrylyl-CoA reductase AcuI, Acryloyl-coenzyme A reductase AcuI.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reductase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHBJ_BACSU
Sequence: MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTNYVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDGTIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDTTFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVKISE
What are the official names of this protein?
Putative efflux system component YhbJ.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ILVD_BIFLO
Sequence: MTEMRSAKIMSGRVFAGARALYRAAGVSGDDMGKKPIIAIANSFDEFLPGHVHLNKVGRIVSEAIREAGGIPREFNTMAVDDGIAMGHTGMLYSLPSRDIIADTVEYQCNAHCADALICIPNCDKVVPGMLMAALRLNIPTVFVSGGPMEAGTTVLADGTVKSTDLIDVMYATADDNVSDEELLNYEKTVCPTCGSCAGMFTANSMNCLTEAIGLALPGNGTILASHSYRKDLFKRAAKQVVKIAHQYYDDSDDSVLPRSIATKEAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGKWEISDVHRAGGITGILGELDRAGKLHTNVHSIDYPTLEAKLADWDIMRPTCTEEAQQMYKAAPGHIISPEPWTHTTLFDSLDRDRTNGAIHDINHPEIHEGGLAVLRGNLAPDGCVVKTAGVPPEIWKFRGPALVVDSQEQAIEVILNDTLKPGMALVIRYEGPKGGPGMQEMLYPTSFVKGKGIGKQVAMLTDGRYSGGSSGLAIGHMAPEAANKGPVALIKNGDIIDIDIEARSVNVELTDEQLDERRRELEAGDGYVAHRNRHVSQALKAYAAFARSADKGATRDPELINKLSGLD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: NUOCD_CERS4
Sequence: MSLDQAIPEALQALRTRFGAAVRAEQATGEAFPVLWLDASVWEAAHRFLREEIAAPFPLLADLWAIDESLRQHRTGQPASRITLCSHLVSLVRNADLRLKLATDGRAPSIAGVYANADWYEREAHDMFGLDFGRETRRILMPPTWEGHPLLKTHYARATEKPPFVLTDRLFEAEERATITDPDLLGLPKLRDGEELMVLNFGPHHPSTHGVLRILLGLDGEEVVWAWPDIGYHHRGAEKMAERQTWHGFIPYCDRIDYLGGVISELPYLLAVERLCGIAVPPRAQMIRVMLCEFYRIMNHLLFYGTMAQDVGAMSPVFYMFTDREKGHEILNAITGARMHPAFFRIGGVAMDLPDGWDAMVRGFLDWMPARLDEYERMVLRSELFRARTVGVGAYDTDTALTWGTTGPGLRATGCDWDLRKLRPYSGYEQFDFEVPLGQRGDIFDRTRVRADEMRESLKIIRQCLENMPEGPVKADHPLTTPPPRGAMQKDIETLIAHFLQSSWGTVVPAGEATGQIEGHRGLTQYAIVSDGGTQSYRTRIRTPSFAHLQMIPKIVPGMTVADLVAHIASIDFVMSDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VA543_SCODE
Sequence: MNFVIYGVIVVLTSQLYVDGWGCQMSERGLDKKMKNKILKHHNELRQKVANGQERGQPTASNMKQLRWNDELAANAQRAAERCIFQHTSDEGRKTTKYGVAGESMYAGTFSNPLKTAVDMWYEEVRDVNPSILDSYDYYPGAVIGHYIQLVWAETEAIGCGYAKSAADGESYVFCHYAPHGLFPQQSVYKRGSPASACKKGQSSRYPGLCK
What is the function of this protein?
Shows trypsin inhibiting activity.  The protein is highly thermally stable, since its incubation in boiling water during 10 minutes does not reduce its activity.
What are the official names of this protein?
Scoloptoxin SSD43, Cysteine-rich venom protein, CRVP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family. Venom allergen 5-like subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS3A_SYNRU
Sequence: MAVGKDKRISKGKKGGKKKIVDPFSKKDWYDIKAPPRSRRARSGRRCHRTAGTKIASDGLNFRVFEVSLADLQNDEDQAFRKIKLRAEDVQGKNVLTNFWGMDFTTDKLRSLVRKWQSLIQAHVDVKTTDNYQIRIFCIAFTKKRPNHTRNFYAQSSQIAIRRKMREIMVKEAQTCDLKELVAKFIPEVIGKEIDEWRSQGIYPLQSTFIRKVKILKAPKFDLMKLMEVHGDYNEEVGAKIREASSRG
What are the official names of this protein?
40S ribosomal protein S3a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_STRPF
Sequence: MTDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVASRHHVEVITTCFEDALQEAGISASDLSAVAVTYGPGLVGALLVGLAAAKAFAWANHLPLIPVNHMAGHLMAAREQKPLVYPLIALLVSGGHTELVYVPEPGDYHIIGETRDDAVGEAYDKVGRVMGLTYPAGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSAFINLHHNAKQKGNELILEDLCASFQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCGDNAGMIALAAAIEYDKQHFANMSLNAKPSLAFDQFPDSFVIN
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_POLSX
Sequence: MAHPAQLGLQDASSPIXEELLHFHEDALMIVFLISTLVLYIITTTVST
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ATP6_GEOSM
Sequence: MVHPYLFLNFFRELLHPLGFSEAGADAVVYTWLIMIGLVVLSIAATKRLQAVPSGLQNFMEVIVGGIENMLVETMGEHGKPFFPLVATLALFILVSNLIGLIPGFFPPTANINTTAACAVVVFVTTHIVGVKHHGAGYIKHFLGPIAWLAPMMFFIEVIGHLSRVISLTLRLFGNMNGHELVLIIFFGLAPFVVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEHAH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NTRK2_CHICK
Sequence: MVSWRRRPGPGLARLWGLCCLVLGCWRGALGCPASCRCSSWRIWCSEPVPGITSFPVPQRSTEDDNVTEIYIANQRKLESINDNEVGFYVGLKNLTVVDSGLRFVSRQAFVKNINLQYINLSRNKLSSLSKKPFRHLGLSDLILVDNPFKCSCEIMWIKKFQETKFYTEAQDIYCVDDNNKRIALMDMKVPNCDLPSANLSNYNITVVEGKSITLYCDTTGGPPPNVSWVLTNLVSNHESDTSKNPASLTIKNVSSMDSGLWISCVAENIVGEVQTSAELTVFFAPNITFIESPTPDHHWCIPFTVKGNPKPTLQWFYEGAILNESEYICTKIHVINQSEYHGCLQLDNPTHLNNGAYTLLAKNEYGEDEKRVDAHFMSVPGDGSGPIVDPDVYEYETTPNDLGDTTNNSNQITSPDVSNKENEDSITVYVVVGIAALVCTGLVIMLIILKFGRHSKFGMKGPSSVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPHMRLNIKEIHSLLQNLAKASPVYLDILG
What is the function of this protein?
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.  Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4 (PubMed:8287802, PubMed:8670834).  Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2.  Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:8670834).  Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades.  Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth.  Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival.  Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity.  Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation.  PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival.  Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions.  May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia (By similarity).
What are the official names of this protein?
BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Trk-B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Postsynaptic density. Note=Internalized to endosomes upon ligand-binding.