PharMolix/UniProtQA huggingface dataset:
Protein: RF3_STRP7
Sequence: MNIQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVKGKKTGTFAKSDWMDIEKQRGISVTSSVMQFDYDGKRVNILDTPGHEDFSEDTYRTLMAVDAAVMVVDSAKGIEAQTKKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILGIASYPMNWPIGMGKAFEGLYDLYNQRLELYKGDERFASLEDGDKLFGSNPFYEQVKDDIELLNEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLEIFLKFAPEPHGHKKTDGEIVDPYDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNVTQFMAESRENVTNAVSGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVSAKNVMKQKSFHKGIEQLVQEGAVQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAEVVMTPMGKKTVRWIKPEDLDERMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDVELEEKM
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIFK_METTH
Sequence: MKSGFGEGAYFITRSVYRDQFREKLGFDPFPGTLNIEVGDPEIVERIREGAPVIQGGGGFGDVLYVKALLNGVVEGAILFPLKTHHRQGCLEFVAPVNLRKTLKLRDGDTVSLDIDTSEIQE
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: XNI_KLEP3
Sequence: MAVHLLIVDALNLIRRIHAVQGSPCVDTCLHALEQLIVHSQPTHAVAVFDDEDRAHGWRHQRLPEYKAGRAPMPETLVAEMPALRAAFEQRGIRCWASPGSEADDLAATLAVKVAQAGHQATIVSTDKGYCQLLSPTIRIRDYFQKRWLDAPFIASEFGVTPEQLADYWGLAGISSSKVPGVAGIGPKSAAQLLNEFQDLEGLYARLAEVPEKWRKKLAAHQEMAFTCREVARLQTDLQLDGNLQQLRLTR
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: GTPBA_DANRE
Sequence: MVWTSRICFRKYGNFVDNVRLYVRGGTGGMGLPRLGGHGGDGGDVWVVAKKDTRLKQIKDKHPDKRFIAGVGSNSSIQALRGAKGEDVEVFAPTGISVTSDHGRMLGELNREGDKLLVAKGGRGGSPQSGFLPNKGQTRNIRLDLKLIADFGLVGFPNAGKSSLLTALSHAKPKIANYPFTTIKPEIGKVMYDDHKQVSVADLPGLIEGAHVNKGMGHKFLKHVERTKQLMFVVDVCGFQLASKTPFRSAFETVLLLSKELELYKEELLSKPAILVINKMDLPEAQSHFQELEAQLENQGESIHLFSEDVIPKSLMHFTHIVPVSAMTGHGLPLLKSLIRQSLEEQDTIDTEAQRSQKILELRREIPSSSIPSWGLPQPT
What is the function of this protein?
May be involved in the ribosome maturation process.
What are the official names of this protein?
GTP-binding protein 10.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Found in the dense fibrillar compartment region of the nucleolus.
Protein: ASTD_ECO81
Sequence: MTLWINGDWVTGQGALRVKRNPVSGEVLWQGNDADAAQVGQACRAARAAFPRWARLSFGDRQVRVERFAGLLESNKAELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHVRTGEQRSEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGDAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHHQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLFLKSGTQGDAFLARLVAVSQRLTPGTWDDEPQPFIGGLISEQAAQQVVTAWQELEAMGGRTLLAPRLLQAGTSLLTPGIIEMTGVTGLPDEEVFGPLLRVWRYDNFDEAIRMANNTRFGLSCGLVSPEREKFDQLLLEARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLPATLNPGLDFSDEVVR
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: ADDB_LEVBA
Sequence: MSLQFILGSAGQDHRTPMVTALAQQVTAHPTDQSYYLVPNHIKFETEVDVLSALKEQIAPEQALFAQTQVQVFSFTRLAWFFMKNEPIYQLPRISPAGLNMLIYQIIQTHADELTIFRGEVDRPGFVSQLATQLAEFKVGQVTAADLMSAIEQLDTTNTDLQAKLHDLMIIYEAFETQMMGKFVENTDLLNQLATYLEQQVDLQHAHFYLEGFSQLSAQERQLVAILIQRSASVTVALNLDHGYPQKLPDKTTLFFQSAKLYQQLYMVAQANRVPVLIDQQAKTARVSADLQALDTYWQASQTLSPQPSAVEKPTHIQIVQAANRYVEVSRVATQIRQLVATGNYRYRDFLVLTRHLDAYQTVIDPIFQAQAVPYFDDADIRMADHPFVELLNALFDVQRRNYRYADVFRVLKSELLLPRDADGELMAVPAYRQALALTENFVLKNGLEGQHWWTQDKDWVYNRFAVGDGGVQTTRDDQISAQINRIRRFVKQTLPPFFARLKVAATYTDAAAVLYQFVANAGVSERLMTWRDQAIAAGDLTKAGQPEQTWAAFCDILDEFHTILGDLPTVLPDFQALLQAGFAGAKFSQIPSTLDQVVISESGIVQANNRKITFIMGATADTMPDNQIPTTLLADNDRQDLSARLQQVDDGTYLRDDAATQLAGEPYLNYLAFMSGSERLIFSYPAMSDDARSGLQLSPYVARIKDYFGLSIDIAAANPVAEDEAILPFVGTRRTTLRHLVQASHDSQLREVPLSRSWLYVLNLLRTDPTYGELTTKLLGSLSYRNVPTQLTPDIVTQLYGTKINTSISKLEEYYANPYAYFLKYGLNLQERDVFALSPASTGEFFHATLDGLMKLVNDQKLNLAALDDQQLREMTDEVMAKLLDTTENPQFAILESSHRMGYIRQQLMKTMRQMAKTLQEQSKRTKLRPKRTEVQFGLGDERGLAALSFDVGKRRQVTVRGRIDRLDAVQVKDKTYLGIVDYKSSEHKFSYQEAYYGRAMQMLTYLDAVKQNLPTLLDAPTAKDAELAGAVYLHLQNPILKAAEVLGEDPLTSLLKAEQYQGLLLDDPDLLTNLDTLFGTPDYSGSSLLFRGLRRTKTGKITSYGKLLVNSNELDLLLTHTERLIKRAATDIFDGRVDLAPFREQNRTALQYSPYKSVMQFDPLLKENNYRDLPSLNKDDVMARIAAEQEQEATDEHEI
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: RL35_STRP6
Sequence: MPKQKTHRASAKRFKRTGSGGLKRFRAFTSHRFHGKTKKQRRHLRKAGLVSSGDFKRIKAMVTGL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: Y993_METM6
Sequence: MKKITLIGSELAKTGNEFIYLGPLEECEPCRFKRICHNNLDVGTRYKIVSVRSANHPCTVHENGVKVVEVMPAEFTIIIESKKALEGVTLTHSDVHCDRVCCENYLSCHPEGISGKYRVSSILPEKVECKKGNSLKKISIIPVQQ
What are the official names of this protein?
UPF0179 protein MmarC6_0993.
What is the protein family that this protein belongs to?
Belongs to the UPF0179 family.
Protein: RBSD_STAAT
Sequence: MKKSAILNEHISKAIATIGHFDLLTINDAGMPIPNDHRRIDLAVTKNLPRFIDVLATVLEEMEIQKIYLAEEIKEHNPTQLQQIKQLISSEIEIIFIPHEEMKSNLAHPLNKGNIRTGETTPYSNIALESNVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLOB1_DICDI
Sequence: MDSSTANSSGTAISKAEWKPDQSSLECNDCQLPFTLIRRRHHCRKCGSIFCDSCSSFYSILPIEYGYTGQQRLCRSCNNSFEQKKQYFETDALVAQFQLRSTAQFEYSKPLQDIGHTKHGLRKSYCMAKNSMGGGEECVVSIITPTPSSCPWSMSNEKKKRKFEKTLLSLKHPYILTPINVEVSGANDKILVIRTFFKQGSLRDQVYKSKPLSPYDTKYIYKQPKSSSSSSSSSSSSSQSQSVLPIKSIQKYCKQILESLLYLKSKGIQFSHLHLSNILINQSNDTCQLVDIENCLLGMKPLFNDYIYGIGLPQSFKDNLEVICFGHCLFEMIIGIPLGDHSNINSFIPLFPDKVFLLLQQIFSEKTPTLEELVKNPWFEVTTTIEQQSLQNGKLKKSQLTFIKDNSNKFESPKVSLSGSFSSSNISKLSSSSSNNNSNNNNNNNNNSNTFNNISSNDDKRKSMKLPSSTSLLNNSFNLSNNNNPSSPSTSTISPNSSLISSPPKTPILQTFTPPPPPPPPKSAPPPPPPPSSSKLPPSSSSRNSLLESIRNADNAKKLKKTTPNTKPKSSIGPHSLKPSSTKKK
What are the official names of this protein?
Probable inactive serine/threonine-protein kinase slob1, Slowpoke-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: RPOB_MYCGA
Sequence: MKKNSAFHNTQYSPKVVRRDYSKVHNKYNPLNLPGIQVNAYKQFLEKELEEIIGSYFPIKSPNGKYSVEFHGMKILDPQITKEEASAESKTYDASLYVNLSLVNHQTGTVKKISKKSAKSKAEGIYFADIPLMTENGAFIVNGIEKFVVAQIVRSPGAYILNKSQVKLSNSRKRNQEGYICEVFPSKGTLMLFYIAENKDFVQAVVRDVGGESAKVFSITTLLKAFGLSEIKIKEIFNNNDYILRSLESEFYNEKQILNEADIAQLIRDIESDRISKVKSLPIDQKWKNLVLDWYKLNQEKQELLNSSNPNPTKIESLNTHIGVVLRKLICEKAAKHVIQELSISTRSLDNVSQKEEISYQSILLQHFFQKKRYDLSSAGRHKFVRKLRVSERLYQRTIAQDIKDLDGNVVIKQGTLMLKEQLDLFKRLSKEKRLDIIKQIDFINPELNTQFTDVNTYEEVQIYVNNDLRNETTQIIGIDGSNESIETLTLADLISIVSYIVNLPFNIGLYDDIDHLGNKRLKLINELLKSKVQTGMMRIEKYIKDKLQTADGNNKLADQDAENDPDSDLGTKSSNDLTVKSVINPKPFQIVIKDFFNTHQLTQFLDQQNPLSELTNKRRISAMGPGGISREDPNLDIRDVHYSHYGRICPIETPEGMNIGLIMSLAFYATIDKNGFLMTPYLKVENGKITDKVEHLTALREDEYIIAEASSYMDVAKDGTINNEKIIARYRSSQDLYDPKQVDYIDVSPKQVVSVAASLIPFLENDDSSRALMGANMQRQATPLLKPYSPLVGTGVEYKIAQDSGMLVTAKNPGTVTYVDASKITVKGEDNKSTDYNLLKFVKSNKNTCYNQSPIVAVGDKIETNQALADGPSMKNGELALGQNVLVGFTTWSGYNYEDAVIISDRLFKDDVYSSIHIDEYTIECLRTKNGDEEITRDIPNISESAKRYLDEEGVIMVGAEVKEGDILVGKTSPKGQVELTPEEKLIQAILGDKVKQVRESSLKVPNGGDGIVAGIKRFSIANGDELEDDVLELVKVYVVQKRKIQIGDKVAGRHGNKGIISKIVAQEDMPHLEDGTPLDILLNPLGVPSRMNIGQIFELHLGYAARELAKAKLIEACFDKKLADQLDTVFGLEKSKTQSLIKNLVEHMKSIGVTSLAQTKNRVRTIDIDIVLKQLGLTYDDLAFKIATPVFEGVNMEDLKAIMSEAGIDPDKTEGKFKLIDGRTGEPFEKPISVGIMYMLKLDHMVDDKIHARAVGPYSKITQQPLGGKSQNGGQRFGEMEVWALQAYGAAHNLREILTIKSDDVRGRNMTYNAIVKGLSIPEPGVPESFKLLTKELQGLGMTLNVLYDDDSIENINNISVVDESLEPKIHDAEFDTFTLDDYNDDNF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: MOAC_CAUVN
Sequence: MSKLTHIDDQGRARMVDVSEKPATAREAVAAGFVRMSAETLALAISGSGRKGDVRAVAELAGVMAAKKTSDLIPLCHPLALSKVEVAVEPADGGLSVTARVKTTGPTGVEMEALTAASVACLTIYDMLKAAEKGMVIEAVRLLEKTGGKSGDWKADQP
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: RS18_DICTD
Sequence: MSNEKASTKAPKFAYPSKKKYCIFCSEKIDYIDYKNVERLKRFMTEKGKIIPRRISGNCARHQRQLSTAIKRARYMALLPYVVK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RAD50_SACS2
Sequence: MRIDKITLTNFLSHEHSEIQFMGEINVIVGQNGAGKSSIIDGIVFSLFRTHSRGNNDNLIRKGSNRGSVTLYLSNEKDKIEIIRDIRSTTEDRLIRNQFPIARSATVVSNEIEKILGIDKDIALSTIIVRQGELDKILENFQEIMGKILKLELIEKLIDSRGPIVEFRKNLENKLRELDRIEQDYNNFKKTVEEKRARVLELKKDKEKLEDEIKNLEKRIKDIKDQFDEYEKKRNQYLKLTTTLKIKEGELNELNRSIEELRKQTENMDQLEKEINELENLRNIKLKFEKYEVLAKSHTEMSANVINLEKEIEEYEKAIRRKEELEPKYLKYKELERKLEELQPKYQQYLKLKSDLDSKLNLKERLEKDASELSNDIDKVNSLEQKVEETRKKQLNLRAQLAKVESLISEKNEIINNISQVEGETCPVCGRPLDEEHKQKIIKEAKSYILQLELNKNELEEELKKITNELNKIEREYRRLSNNKASYDNVMRQLKKLNEEIENLHSEIESLKNIDEEIKKINEEVKELKLYYEEFMRLSKYTKEELDKKRVKLDEMKKKKEEIEKEMRGLESELKGLDRKALESKILDLENKRVKLDEMKKKKGILEDYIRQVKLLQEEVKNLREEVNIIQFDENRYNELKTSLDAYNLSLKEKENRKSRIEGELESLEKDIEEISNRIANYELQLKDREKIINAINKLEKIRSALGERKLQSYIIMTTKQLIENNLNDIISKFDLSIKNVEMEIMPKTGRGRSSSGDILVYTNSGDTLPIVSLSGGERIALSIALRLAIAKALMSNTNFFILDEPTIHLDDQRKAYLIEIIRAAKESVPQIIVVTHDEEVVQAADYVIRVEKRGNKSFVREET
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair.  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA.  Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
What are the official names of this protein?
DNA double-strand break repair Rad50 ATPase.
What is the protein family that this protein belongs to?
Belongs to the SMC family. RAD50 subfamily.
Protein: ASND1_HUMAN
Sequence: MCGICCSVNFSAEHFSQDLKEDLLYNLKQRGPNSSKQLLKSDVNYQCLFSAHVLHLRGVLTTQPVEDERGNVFLWNGEIFSGIKVEAEENDTQILFNYLSSCKNESEILSLFSEVQGPWSFIYYQASSHYLWFGRDFFGRRSLLWHFSNLGKSFCLSSVGTQTSGLANQWQEVPASGLFRIDLKSTVISGCIILQLYPWKYISRENIIEENVNSLSQISADLPAFVSVVANEAKLYLEKPVVPLNMMLPQAALETHCSNISNVPPTREILQVFLTDVHMKEVIQQFIDVLSVAVKKRVLCLPRDENLTANEVLKTCDRKANVAILFSGGIDSMVIATLADRHIPLDEPIDLLNVAFIAEEKTMPTTFNREGNKQKNKCEIPSEEFSKDVAAAAADSPNKHVSVPDRITGRAGLKELQAVSPSRIWNFVEINVSMEELQKLRRTRICHLIRPLDTVLDDSIGCAVWFASRGIGWLVAQEGVKSYQSNAKVVLTGIGADEQLAGYSRHRVRFQSHGLEGLNKEIMMELGRISSRNLGRDDRVIGDHGKEARFPFLDENVVSFLNSLPIWEKANLTLPRGIGEKLLLRLAAVELGLTASALLPKRAMQFGSRIAKMEKINEKASDKCGRLQIMSLENLSIEKETKL
What are the official names of this protein?
Asparagine synthetase domain-containing protein 1, HCV NS3-transactivated protein 1.
Protein: RIMO_TREDE
Sequence: MDLHGCAKNQVDAELIIGIMENLSWKNTSDPDEADLIIVNSCGFINSAKEESINAVLQAKAAHPKAKVLLAGCLAERYADILKNDLPEADGIFGNGNLSLLPQLIDSMFPKKTSDEKFIEKTLVPPQIGICGGERPKILNFPRSTYIKITEGCDNFCSFCAIPIIRGRLRSRPIKDICDEIKTFLKKSFYEFNLIGQDLAAYQTGKDDLSEDELHRENCSGLALLLKSISKIKGNFKIRLLYIHPDHFPLDILPIMTADKRFLPYFDIPFQSGAQKIIRAMNRNGAAEVYLDIIKNIREAFEKTNSPYGEPQIRTTFLVGFPGETDEDFNETIKFLKELRPLWSGGFTYSREEDTPSYSFKGKVPKKTAEARLAEIQNAQTSITEKKLDSFIGKEIEVLVEELIQAEDKTFLALGRAWFQAPEVDGAVVLNFNLNKKDIDGNPIAPGSIVKARIAARNGFDLEAVAV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CERS2_BOVIN
Sequence: MLQTLHDYFWWERLWLPVNLTWADLEDRDGRVYAKASDLYITLPLALLFLIIRYFFELYVATPLAALLNVKEKTRLRAPPNPTLEHFYMTSGKQPKQADVELLSRQSGLSGRQVERWFRRRRNQDRPSLLKKFREASWRFTFYLIAFIAGTAVIVDKPWFYDLRKVWEGYPIQSIIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILISFSWFANYVRAGTLIMALHDSSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITRLVILPFWILHCTLVYPLELYPAFFGYYFFNFMMGVLQLLHIFWAYLILRMAHKFITGKVVEDERSDREETESSEGEEAAAGGGAKNRPLANGHPILNNNHRKND
What is the function of this protein?
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (By similarity).  N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity).  Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain.  Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (By similarity).
What are the official names of this protein?
Ceramide synthase 2, CerS2, LAG1 longevity assurance homolog 2, Sphingosine N-acyltransferase CERS2, Tumor metastasis-suppressor gene 1 protein, Very-long-chain ceramide synthase CERS2.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PURA_COPC7
Sequence: MSVSVVLGSQWGDEGKGKLVDILAGDIDVCARCAGGNNAGHTIVVPIDGVEKSFAFHLLPSGLVNPKCTGLLGNGVVIHLPSFFAELDALESQGLDCTNRLFISDRAQLVFDFHQIVDGLKEVELGGSSIGTTKKGIGPAYSGKASRSGLRVHHLFEPETFAAKFRKVVEGRFKRYGHFEYDTEGEIERYRKLAERLRPYVVDSVAFIHKALASGKRVLVEGANALMLDIDFGTYPFVTSSSTSIGGVCTGLGIPPKMVGKTIGVVKAYTTRVGAGPFPTEQLNDVGVHLQEVGHEYGTTTGRRRRCGWLDLAVMKHSCLINGYDAFNLTKLDVLDGLDEIKVGVSYSLDGKELSSFPADLELLSRVEVNYVTLPGWKTPITEIRNYDDLPANCKKYINFIEEQLKVPIEWIGVGPGRDAMITKRKDQ
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI3_FUSSP
Sequence: MSASSSSALPPLVPALYRWKSTGSSGRQVQRRCVGAEAIVGLEEKNRRALYDLYIATSLRNIAPASTLLTLQNLKEMFELALLDARFEHPECACTVSWDDEVPAIITYESPESNESARDWARGCIHVQPTAKSALDLWSEMEEGRAAANDNTPSKSIELFLLSDVSTDSTPIPQDATVEILFHSNHLFWDGIGCRKFVGDLFRLVGSYIGRSDSREMKKIQWGQEIKNLSPPVVDSLKLDINTLGSEFDDKCTEYTSALVANYKSRGMKFQPGLALPRCVIHKLSADESIAIVKAVKTRLGPGFTISHLTQAAIVLALLDHLKPNDLSDDEVFISPTSVDGRRWLREDIASNFYAMCQTAAVVRIENLKSIAVSHKDEKELQVRALESACRNIKKSYRQWLENPFLQALGLRVHNFEASYLHAKPIPFEGEANPLFISDGINERFIPHEIKQTATGENVLSVESIDFVVNQSLPYLAIRLDSWRDASTLNIIYNDANYTEAEVQKYLQSIVEFMLAFRL
What is the function of this protein?
15-O-acetyltransferase; part of the core gene cluster that mediates the biosynthesis of trichothecenes, a very large family of chemically related bicyclic sesquiterpene compounds acting as mycotoxins, including T2-toxin (PubMed:8593041, PubMed:19319932).  The biosynthesis of trichothecenes begins with the cyclization of farnesyl diphosphate to trichodiene and is catalyzed by the trichodiene synthase TRI5 (PubMed:3800398).  Trichodiene undergoes a series of oxygenations catalyzed by the cytochrome P450 monooxygenase TRI4 (PubMed:7651333).  TRI4 controls the addition of four oxygens at C-2, C-3, C-11, and the C-12, C-13-epoxide to form the intermediate isotrichotriol (PubMed:16917519).  Isotrichotriol then undergoes a non-enzymatic isomerization and cyclization to form isotrichodermol (PubMed:2317042).  During this process, the oxygen at the C-2 position becomes the pyran ring oxygen and the hydroxyl group at C-11 is lost (PubMed:2317042).  More complex type A trichothecenes are built by modifying isotrichodermol through a series of paired hydroxylation and acetylation or acylation steps (PubMed:11352533).  Isotrichodermol is converted to isotrichodermin by the acetyltransferase TRI101 (PubMed:10583973).  TRI101 encodes a C-3 transacetylase that acts as a self-protection or resistance factor during biosynthesis and that the presence of a free C-3 hydroxyl group is a key component of Fusarium trichothecene phytotoxicity (PubMed:10583973).  A second hydroxyl group is added to C-15 by the trichothecene C-15 hydroxylase TRI11, producing 15-decalonectrin, which is then acetylated by TRI3, producing calonectrin (PubMed:9435078, PubMed:8593041, PubMed:19319932).  A third hydroxyl group is added at C-4 by the cytochrome P450 monooxygenase TRI13, converting calonectrin to 3,15-diacetoxyspirpenol, which is subsequently acetylated by the acetyltransferase TRI7 (PubMed:12135578, PubMed:11352533).  A fourth hydroxyl group is added to C-8 by the cytochrome P450 monooxygenase TRI1, followed by the addition of an isovaleryl moiety by TRI16 (PubMed:12620849, PubMed:14532047).  Finally, the acetyl group is removed from the C-3 position by the trichothecene C-3 esterase TRI8 to produce T-2 toxin (PubMed:12039755).
What are the official names of this protein?
Trichothecene 15-O-acetyltransferase TRI3, Core trichothecene cluster (CTC) protein 3.
What is the protein family that this protein belongs to?
Belongs to the trichothecene O-acetyltransferase family.
Protein: NADK_HALLT
Sequence: MQVGIVARKGSERAVAVADELRDAVAGAGASVWLDAETADALGEPAAGREVDALADCDLAVAVGGDGTFLFVARNAGDTPIVGVNLGEVGFLNAVPPEAAEEAVVSEVEAFDRGEMNVREAPRLAARTDEWTSVPAANEVVIQGARRGPGAGIDYEVRVDGSRYAGGHADGVLVATPTGSTAYNLSEGGPLVHPAVSGLVVNEMVAEEGMPPIVVDADATVTVAVEGVDEVVVASDGRNVTTLPAPTEVTVERTTPPMRIAGPPSDFFAALEKLS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALBA2_ARCFU
Sequence: MAEHVVYVGNKPVMNYVLATLTQLNEGADEVVIKARGRAISRAVDVAEIVRNRFMPGVKVKEIKIDTEELESEQGRRSNVSTIEIVLAK
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).
What are the official names of this protein?
DNA/RNA-binding protein Alba 2, Af1.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: CCA_SHEPA
Sequence: MKIYLVGGAVRDKLLKLPVKDHDYMVVGATPEQMLSLGYNQVGKDFPVFLHPKTGQEYALARTERKTAAGYGGFSVDAAPTVTLEQDLLRRDLTINAIAQDDAGNLYDPYNGIADLEKRILRHVSDAFVEDPLRVLRVARFAARFHGLKFTIAPETLSLMTTLSRSGELEALTAERVYLELDKALSTDNPQVFFQVLKECGALAVLFPEIEALFGVPQPENWHPEIDTGIHTMMVLEQAAKLSDDNSVRFAALVHDLGKALSPKEHLPKHHGHGQKGLPLIKSLCERFRVPNEYRDLALLVCDQHQNIHKITELRADTLVKLFDKADFWRKPQRLEQLLIACEADSKGRKGLEQTAYPQADYLKQCFAAASAVEVKSIIAQGYKGAEIRTQLNVKRIAEVQAVKGLQPIEAK
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: RNC_BACTN
Sequence: MLRNQIDKIRLLFRKDRESYLCFYRILGFYPHNIQIYEQALLHKSSAVRSEKGRPLNNERLEFLGDAILDAIVGDIVYKRFEGKREGFLTNTRSKIVQRETLNKLAVEIGLDKLIKYSTRSSSHNSYMYGNAFEAFIGAIYLDQGYERCKQFMEQRIINRYIDLDKISRKEVNFKSKLIEWSQKNKMEVSFELIEQFLDHDSNPVFQTEVRIEGLPAGTGTGYSKKESQQNAAQMAIKKVKDQTFMDTVNEAKSQHSKPSEVETESVEPELTESETMEPDTLETEAPEAETTADKVETTVNEVEATETEKE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_MYCTO
Sequence: MAVVPIRIVGDPVLHTATTPVTVAADGSLPADLAQLIATMYDTMDAANGVGLAANQIGCSLRLFVYDCAADRAMTARRRGVVINPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRAKWARVTGLDADGSPVSIEGTGLFARMLQHETGHLDGFLYLDRLIGRYARNAKRAVKSHGWGVPGLSWLPGEDPDPFGH
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.