PharMolix/UniProtQA huggingface dataset:
Protein: VIR_HUMAN
Sequence: MAVDSAMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIPPGVRAHSSLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRVISHDRDSPPPPPPPPPPPQPQPSLKRNPKHADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPVPLPVSGDKEEDAPHREDYFEPISPDRNSVPQEGQYSDEGEVEEEQQEEGEEDEDDVDVEEEEDEDEDDRRTVDSIPEEEEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTAEDLASVPPMTYDPYDRELVPLLYFSCPYKTTFEIEISRMKDQGPDKENSGAIEASVKLTELLDLYREDRGAKWVTALEEIPSLIIKGLSYLQLKNTKQDSLGQLVDWTMQALNLQVALRQPIALNVRQLKAGTKLVSSLAECGAQGVTGLLQAGVISGLFELLFADHVSSSLKLNAFKALDSVISMTEGMEAFLRGRQNEKSGYQKLLELILLDQTVRVVTAGSAILQKCHFYEVLSEIKRLGDHLAEKTSSLPNHSEPDHDTDAGLERTNPEYENEVEASMDMDLLESSNISEGEIERLINLLEEVFHLMETAPHTMIQQPVKSFPTMARITGPPERDDPYPVLFRYLHSHHFLELVTLLLSIPVTSAHPGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHFYDQDEEEGLQSDGVIDDAFALWLQDSTQTLQCITELFSHFQRCTASEETDHSDLLGTLHNLYLITFNPVGRSAVGHVFSLEKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACILILVVVQSSSDVQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEYVKQNIDNLMTPEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTFIRVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKDMRVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANNTWSLMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVIEPHDISVALNTRKLWSMHLHVQAKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIVEDLQSTSEDKEKQYTSQTTRLLALLDALASHKACKLAILHLINGTIKGDERYAEIFQDLLALVRSPGDSVIRQQCVEYVTSILQSLCDQDIALILPSSSEGSISELEQLSNSLPNKELMTSICDCLLATLANSESSYNCLLTCVRTMMFLAEHDYGLFHLKSSLRKNSSALHSLLKRVVSTFSKDTGELASSFLEFMRQILNSDTIGCCGDDNGLMEVEGAHTSRTMSINAAELKQLLQSKEESPENLFLELEKLVLEHSKDDDNLDSLLDSVVGLKQMLESSGDPLPLSDQDVEPVLSAPESLQNLFNNRTAYVLADVMDDQLKSMWFTPFQAEEIDTDLDLVKVDLIELSEKCCSDFDLHSELERSFLSEPSSPGRTKTTKGFKLGKHKHETFITSSGKSEYIEPAKRAHVVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVPQDGIPPPKRPLKVSQKISSRGGFSGNRGGRGAFHSQNRFFTPPASKGNYSRREGTRGSSWSAQNTPRGNYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSWASANSGSGGSRGKFVSGGSGRGRHVRSFTR
What is the function of this protein?
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755).  Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755).  Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755).
What are the official names of this protein?
Protein virilizer homolog.
What is the protein family that this protein belongs to?
Belongs to the vir family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
Protein: PER1_CYCRE
Sequence: GFDVVDNIK
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall.
Protein: TRUB_SHEB2
Sequence: MARRPKGRFIDGIVLLDKSTGMSSNFALQRVKRFFNANKAGHTGALDPLATGMLPVCLGEGTKFSQHLLDADKRYLVTAKLGERTDTSDSDGEVVQTRAIDFTEAQLLTALDFFRGETQQVPSMYSALKYQGQPLYKYAREGIEVPRESRPITVFELNFIGLEGDELTLDIHCSKGTYIRTIIDDLGEMLGCGAHVIMLRRTQVAQYPYARMVTLEQLEALVAQAHEQQIDPSVLLDPLLLPMDTAVADFPEVNVPDAIAPYLMQGQAVRVPVNADLKTDELVRITLGDIRRFVGIGTMNEDGLLAPKRLIVIHDEPAETD
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RL5_BUCAK
Sequence: MAKLHDYYKDEVIKQLMSQFDYNSVMQVPRVEKITLNMGVGEAIADKKLLDNAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLISIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDDEGRALLAAFNFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: THI4_PHANO
Sequence: MSPPAATFDIPVANTGNGLSLKKDLAVKPAASGVAKSLAEIEHNWEKFTFAPIRESQVSRAMTRRYFNDLDTYAESDVVIIGAGSCGLSAAYTLASKRPDLKIAMVEAGVAPGGGAWLGGQLFSAMVMRKPAELFLNEIGVPYEDEGDFVVVKHAALFTSTLMSKVLNFPNVKLFNATAVEDLITRPAPTSNDPNAVRIAGVVTNWTLVSMHHDDQSCMDPNTINAPLIISTTGHDGPFGAFSVKRLVSMQQLPQLGGMRGLDMRTAEDAIVKRTREVVPGLIVGGMELSEVDGANRMGPTFGAMVLSGVKAAEEAIGVWDERKAQNDE
What is the function of this protein?
Involved in biosynthesis of the thiamine precursor thiazole.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate.  The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.  May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
What are the official names of this protein?
Thiamine thiazole synthase, Thiazole biosynthetic enzyme.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CG121_YARLI
Sequence: MKFPQFDQEIAISYFSDVKNAGQIRNELLSGNPDYQVAFINANTLLSSKHLLAAVYRAVSDQEAGSMKTKNVHSEVLFCLGGNNNIMDSLRRFGIQDDTTNIVAVKIGGGEYTKLVEGTEEPFTDEQIAKNTDIKLVKKVYKLPGTVSLDDRAQVETAAIGALLLRGFS
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.  CGI121 is not required for tRNA modification (By similarity).
What are the official names of this protein?
EKC/KEOPS complex subunit CGI121.
What is the protein family that this protein belongs to?
Belongs to the CGI121/TPRKB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RUS6_ARATH
Sequence: MPSVKLTHHSPPDTIASDSVRLLSRETLRISASLASPPVDDLPPHSPPPPDSQFLHSTLRLICCEEIDGRRFKYVAESDGSGRFKKNSVRAISLESPQTPFDEVGSFLRSYVVPEGFPGSVNESYVPYMTWRALKHFFGGAMGVFTTQTLLNSVGASRNSSASAAVAINWILKDGAGRVGKMLFARQGKKFDYDLKQLRFAGDLLMELGAGVELATAAVPHLFLPLACAANVVKNVAAVTSTSTRTPIYKAFAKGENIGDVTAKGECVGNIADLMGTGFSILISKRNPSLVTTFGLLSCGYLMSSYQEVRSVVLHTLNRARFTVAVESFLKTGRVPSLQEGNIQEKIFTFPWVDDRPVMLGARFKDAFQDPSTYMAVKPFFDKERYMVTYSPTKGKVYALLKHQANSDDILKAAFHAHVLLHFMNQSKDGNPRSVEQLDPAFAPTEYELESRIAESCEMVSTSYGVFKSRAAEQGWRMSESLLNPGRARLCHVKEGE
What is the function of this protein?
Required for normal embryo development.
What are the official names of this protein?
Protein root UVB sensitive 6.
What is the protein family that this protein belongs to?
Belongs to the RUS1 family.
Protein: RL15_THESQ
Sequence: MRLEDLRPTPGAMKKRKRVGRGPGSGHGKTSGRGHKGQKARGSGKVHIWFEGGQTPLHRRLPKRGFNNINKKVYAVVNVKVLEERFEANEEVTPEKLIERKIIKDLKDGIKILGDGELTKPLVVKAHAFSKSAVEKIESAGGKAEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: BIVM_GIAIC
Sequence: MERYPRQRLDDGRWQCVARPQYRYSCAISCLVSIFNHLFNRDMTLDECIAILFPDLKEDPRHYDFGPQASNSAVQSWFKTLCMHYGLSGTSCTIYKEQGRTRTACSKQEALKNIISALNTPRCALLYHCLNHYCIIVGYIISPSTPNRPSNHCVFSGDDGCTLKLLCADGTEAEDVDDSNIWLIVADCGKGTAPLRSLTWEFVHKDISTRPPYAYNARCPERGLLRKTESKGYIPVEIDSVLVNSTGVSTCVRSGGVIKGSSHCIIGFVSD
What are the official names of this protein?
Basic immunoglobulin-like variable motif-containing protein.
What is the protein family that this protein belongs to?
Belongs to the BIVM family.
Protein: ANMK_PECCP
Sequence: MRSGRYIGVMSGTSLDGVDVVLAAIDEHTVAQQASYCHPIPQDIKMAILGMCQGQAVTLSALGQLDTRLGILFAEAVLTLLKETELRAQDITAIGCHGQTVWHEPTGDAPCTLQIGDNNRVAALTGITTVGDFRRRDLAYGGQGAPLVPSFHHALLLHPVERRIVLNIGGIANLSLLVPGAPVRGYDTGPGNMLLDAWIWRHCAQPYDKDAMWAMSGQVNPLLLRRMLTDPYFALRAPKSTGREYFNLSWLERMLAGLPPMAPQDVQATLVELTAMSIAEQVLLVGGCERLLVCGGGARNPLIMTRLSALLPGIEVSTTDECGVSGDDMEALAFAWLASRTLSGLSGNLPSVTGASQETVLGAIYPVNAD
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: TRMD_THEVB
Sequence: MRFDIITLFPEFFASPLSSGLMAKALARGIAEVVLTNPRHFSTDKHQRVDDEPYGGGVGMVMKPEPLFAAVESLPALPRREVIYVTPQGQPLTQQHLWHWSRERDQLVILCGHYEGVDERVVEHLVTQEISIGDFVLTCGEIPALVILNGVLRLLPGTVGKAASLHQDSFEDGLLDYPHYTRPAEFRGWTVPPVLLSGHHGEIAAWRRAQQIERTRQRRPDLYARWLARTQGQAKTH
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_PHYAS
Sequence: MINTNDFKTGQTIKFNNQIYQIIEFLHVKPGKGTAFVRSKLRNLRTGSVIDHTFNAGIKLEPALINKIKMQFLYSSQEKYIFMNTQTYEQLEINKDQLKEKLHYLYEGLLVEIIFYNNNEILTISLPDKISLKVTYAEPGVKGDTKTNSFKDATLETGLVIKVPLFINTGEKIIVNTETGLYLSRDNNK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_ACIF5
Sequence: MNEEKEESPSTEAEGAGAEVVNWEERAETYRNDYLRALADIENLRKRHEKQVEDARNYAVDRFARELLPVVDSLELALASPVEGAESIALLRQGLENTLTLFAKALGKAGIAPIEMGEGRFDPHLHQAIAMVETEGEANRVLAVHQKGYVMHDRLLRPSMVSVSKAPKAAQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POX18_CANTR
Sequence: MSVEVDGFNASPLFKELNDGLADKAKAQEAVKAVNAIIVITLKNKEGKEQSWVLDLKKDGTLAKVDGAAPKGDVQLILKDVDFVKLANNKVNGQKLFMNGKLKVKGNMMKATAIEAVFKKLDPRPKL
What is the function of this protein?
Is involved in beta-oxidation of long-chain fatty acids.  Its exact function is unknown, but possesses a nonspecific lipid-transfer activity, despite the absence of a cysteine residue thought to be essential for the activity of its mammalian counterparts.
What are the official names of this protein?
Oleate-induced peroxisomal protein POX18, PXP-18, Lipid-transfer protein.
What are the subcellular locations of this protein?
Peroxisome.
Protein: ENTP5_MESAU
Sequence: MATPWGAVFFLLMIACAGSTVFYREQQTWFEGVFLSSMCPANVSASTFYGIMFDAGSTGTRIHVYTFVQKAAGQLPFLEGEIFDSVKPGLSAFADQPKQGAQTVHALLEVAKDSIPRSHWKRTPVVLKATAGLRLLPEQKAQALLLEVEEIFKMSPFLVPDDSVSIMDGSYEGILAWVTVNFLTGQLHGHSQETMGTLDLGGASTQITFLPQFSKTLEQTPRDYLTSFEMFNSTFKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRSACLPRWLEAEWIFGGVKYQYGGNQEGEMGFEPCYAEVLRVVQGKLHQPEEIRGSSFYAFSYYYDRAADTHLIDYEKGGVLKVEDFERKAREVCDNLESFTSGSPFLCMDLSYITALLKDGFGFADGTLLQLTKKVNNIETGWPGGHLSPAAVSGHLQLRLSVPLETCTSELLFTGRRGLGHFLQLRWRKPGLKPIDWLY
What is the function of this protein?
Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (By similarity).  In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases.  UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose.  Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose.  Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity).
What are the official names of this protein?
Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, ER-UDPase, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Nucleoside diphosphatase, Proto-oncogene cph, Uridine-diphosphatase ENTPD5, UDPase ENTPD5.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Secreted.
Protein: CAPE_STAAU
Sequence: MKLKYKVILIINFVTVLFSIFTFIGYLNNLIGFRVVTISLCITIAMTVYLLYKKRKGFLLVYLIYLFLTNFGVFVTNIFLANPLVEYHGDLSWYYINTSNLFSIATFAILTFTILSNFISVFSKINPSRKFDIKSKGNNLFYYTGILFIIGFTIQFLFYIITGRLAINTYGDYVSSIQELPMYTYGIFFFSIGIAFAFSNVKKTHIKYLVIILTPQVLFFLITGNRGEVFYPILSALGVLIVRNYKIKWWMIITIVFTLFFVIPFIKVFRNMDSSSIEKVDINWFSSLVEIGYTLRPLGYVTRWIDGGESIVYGKSYLAPIQNIFSYIIPGLQPVNYEMVGYGFRYRLPGMGFNVIAEAYYNGAIVGVLIVMVLLVLLLWKFTNFKSFEMLSMGTAIVSVLINNIRNAFSFVPAYILIIIVIVIILLFIDSYLKKETKAD
What is the function of this protein?
Required for the biosynthesis of type 1 capsular polysaccharide.
What are the official names of this protein?
Protein CapE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLUQ_NEIMF
Sequence: MYTGRFAPSPTGLLHIGSLLTAAASYADARSNGGKWLVRMEDLDPPREMPGAASHILHTLEAFGFEWDGEVAYQSRRYALYEETLCRLQTAGLVYPCHCSRKDWQAAAVHGADGFVYNGRCRNPQQRPALQGKQPAWRIRVPDRDIGFSDGIVGGYAQNLARDIGDFVLLRADGYWAYQLAVVADDAEQGVTHIVRGQDLLVSTPRQIYLQQCLGVPTPQYAHLPLLTNAQGQKWSKQTLAPALDLNRREQLLRQVFRYLKLPEAPETDRPAELLDWAVAHWDMGKVPKHAITTP
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: MDCC_XANCB
Sequence: METLRYRFDGRNGARTGLDHALVGVVASGNLEVLVERVPLGGAMEIEIVTAARGFGEIWQAVLDDFAARHSLQDVRISINDVGATPAVVSLRLEQAIDVLQGADA
What is the function of this protein?
Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.
What are the official names of this protein?
Malonate decarboxylase acyl carrier protein, Malonate decarboxylase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the MdcC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_CLOPE
Sequence: MNNNLLIIAGPTAVGKSDLSVDLAKKLNGEIISVDSMQIYKYMDIGSAKISKEEMGGIPHYLIDFVDPSKEFSVAEFKDLTTEKIKDIQSRGKLPILVGGTGLYINSIICNMNFAESDKDEEYREELEKIANEHGNEYLHEMLKDIDLESYNSIHFNNRKRVIRALETYKLTGKPFSSFKAKNSIYETPYNIYYYVLNMDRAKLYDRINKRVDIMFEKGLLEEVKNLKAMGLTDDMQSMKGIGYKEVLYYLDGKISLEQCIEMIKQGSRNYAKRQLTWFRKDPRAIFIDKDTFASEEDISSKIINDIINS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: MET18_HUMAN
Sequence: MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEERDRKCSAEQFDLPQDHLWEHKSMENAAPSQDTDSPLSAASSSRNLEPHGKQPSLRAAKEHAMPKDLKKMLENKVIETLPGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKIIDEGLKRFIIEITFKFPG
What is the function of this protein?
Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation (PubMed:23349634, PubMed:33693809, PubMed:35674491).  Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins (PubMed:35674491).
What are the official names of this protein?
Histidine protein methyltransferase 1 homolog, Arsenic-transactivated protein 2, AsTP2, Methyltransferase-like protein 18.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL18 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus.
Protein: FIBB_SYNCA
Sequence: QFPTDYDEGEDDRPKSGLGAR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: RS14Z_LISMO
Sequence: MAKKSMIAKQKRTPKYAVQAYTRCERCGRPHSVIRKFKLCRICFRELAYKGQIPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: SYA_THEKO
Sequence: MSMDMTTRMFKEEGWIRKKCPKCGKYFWTLDPDRETCGDPPCDEYQFIGKPGIPKKYTLDEMREKFLSFFEKHESYPHGRVKRYPVLPRWRDDVLLVGASIMDFQPWVISGEADPPANPLTISQPSIRFTDIDNVGITGRHFTIFEMMAHHAFNYPGKPIYWMDETVELAFEFFTKELKMKPEDITFKENPWAGGGNAGPAFEVLYRGLEVATLVFMQYKKAPADADPSQVVEIKGDYYVPMETRVVDTGYGLERLVWMSHGTPTAYDAVLGYVIEPLKKMAGVEKIDERILMENSRLAGMFDIEDMGDLRYLREQVAKRVGISVEELEKAVRPYELIYAIADHTKALTFMLADGVIPSNVKAGYLARLLIRKSIRHLRELGLEIPLAEIVAMHIKELSPTFPEFKEMEDVILDIINVEEKRYAETLRRGSDLVKREIAKLKKKGINELPLEKLILFYESHGLTPEIVAEVAEKEGIKVNIPDNFYTLVAKEAEKQAEKKEAAEYVVDFELVKDLPDTRTLYYEDPFMKEFDARVLKVIADWVVLDQTAFYPEGGGQPYDTGVLEVNGEKVKVTNVQKVGKVILHKVEKPELFKEGVTVHGRLDWDRRIQHMRHHTGTHVLMGALVRVLGKHVWQAGSQLHTDWARLDISHYKRITEEELREIERLANRVVMENRKVTWEWLPRTEAEMKYGFRLYQGGVVPGRVIRVLKIEDWDVQACGGTHLPNTGLIGPIKILRTERIQDGVERIIFAAGEAAINWMQETERLLKRTAEIFRVPPEKVPETAERFFNEWKEARKEVEKLRKELAKLLVYELQEKVEKVGNVEFIGAVVEGTIDDLREAANRLRKENRVVVLISREGHFVVAVGDGLDLKAGELAKVITSVAGGGGGGRKELAQGRIKNPLKAEEAIEEVKKMLG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_THEP1
Sequence: MKVGVALSGGVDSAVALYLLLKEGHEVKAFHMKTKEDEFFIRKEIKKKVCCSPSDTADAMRIAHFLGVEIEIVDVKEIFREKVIEPFKSDLLKGLTPNPCVHCNRFVKFGYLMDYVLNQGFDAFASGHYARIEFSEKYGRKVIKKGVDLKKDQSYFLARIEPWRIERLIFPNGIYTKEEIRKIAEEAGIHVAKKQESQDVCFIPDGSIENFLKDEGITLKEGDLITPEGEVVGRHFGYPLYTIGQRKGFKIEKFGRRYYVRGKIPEKNVVVVSDLEDVFFSGLIAEDPVWHVEVPEEFKCVCRVRKKSEEAPAVVKLRDNEVEVRFEKKVFAVTPGQIAAFYDGDTLLGGAIIKEGIR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.