PharMolix/UniProtQA huggingface dataset:
Protein: DHE2_MYCS2
Sequence: MIRRLSVAFLSTYRGPQADAPGVTSTGPLAVAAHDDLVSDDLVAAHYRLASMRAPGETKAAVYPGDAGSGAALQIVTDQAPMLVDSVTVLLHRHGIAYTAIMNPVFRVRRGLDGELLDVRPAAEAAPGDGADECWILVPITAAADGEALTEATRLVPGILAEARQIGLDSGAMIAALHGLANDLATDLEGHFPNAERKEVAALLRWLADGHFVLLGYQQCVVGDGNAEVDPASRLGVLRLRNDVLPPLTDSDDLLVLAQATMPSYLRYGAYPYIVVVRESPGASRVIEHRFVGLFTVAAMNANALEIPLISRRVEEALAMAHRDPSHPGQLLRDIIQTIPRPELFALSSKQLLEMALAVVDLGSRRRTLLFLRADHLAHFVSCLVYLPRDRYTTAVRLEMQDILVRELGGAGIDYSARVSESPWAVVHFTVRLPEGTAADSVDTSLENESRIQDLLTEATRNWGDRMISAAAAASISPAALEHYAHAFPEDYKQAFAPQDAIADISLIEALQDDSVKLVLADTAEDRVWKLTWYLGGHSASLSELLPMLQSMGVVVLEERPFTLRRTDGLPVWIYQFKISPHPSIPHAPDAEAQRDTAQRFADAVTAIWHGRVEIDRFNELVMRAGLTWQQVVVLRAYAKYLRQAGFPYSQSHIESVLNENPHTTRSLIDLFEALFDPSQETDGRRDAQGAAAAVAADIDALVSLDTDRVLRAFANLIEATLRTNYFVARPDSARARNVLAFKLNPLVIKELPLPRPKFEIFVYSPRVEGVHLRFGFVARGGLRWSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPTLTGDAAADREATRAEGVECYRLFISGLLDVTDNVDKATGAVVTPPEVVRRDGEDAYLVVAADKGTATFSDIANEVAKSYGFWLGDAFASGGSIGYDHKAMGITAKGAWESVKRHFREMGVDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLVAAFDHRDIFLDPNPDAGRSWDERKRLFDLPRSSWADYDKSLISEGGGVYSRQQKSIPISPQVRTALGLDADVEELTPPALIKAILKAPVDLLWNGGIGTYIKAETEADADVGDRANDQIRVCGNQVRAKVIGEGGNLGVTALGRIEFDLAGGRINTDALDNSAGVDCSDHEVNIKILIDSAVTAGKVTPEERTELLLSMTDEVGELVLADNRDQNDLMGTSRANAASLLSVHARMIKDLVDNRGLNRELEALPSEKEIRRRADAGIGLTSPELATLMAHVKLALKDDVLASDLPDQEVFASRLPYYFPTRLREELHGEIRSHQLRREIITTMLVNDLVDTAGISYAYRITEDVGVGPVDAVRSYVAINAIFGIGDVWRRIRAAGDAGVPTSVTDRMTLDLRRLVDRAGRWLLNYRPQPLAVGAEINRFGAKVAALTPRMSEWLRGDDKAIVSKEAGDFASHGVPEDLAYHIATGLYQYSLLDVIDIADIVDREPDEVADTYFALMDHLGADALLTAVSRLSRDDRWHSLARLAIRDDIYGSLRALCFDVLAVGEPDENGEEKIAEWETTNSSRVTRARRTLTEIYKDGEQDLATLSVAARQIRSMTRTSGTGTTG
What is the function of this protein?
Catalyzes the reversible conversion of L-glutamate to 2-oxoglutarate.  Highly specific for NAD.
What are the official names of this protein?
NAD-specific glutamate dehydrogenase, NAD-GDH, NAD(+)-dependent glutamate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: H32_ENCAL
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.2.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: IKBA_CHICK
Sequence: MLSAHRPAEPPAVEGCEPPRKERQGGLLPPDDRHDSGLDSMKEEEYRQLVRELEDIRLQPREPPARPHAWAQQLTEDGDTFLHLAIIHEEKALSLEVIRQAAGDAAFLNFQNNLSQTPLHLAVITDQAEIAEHLLKAGCDLDVRDFRGNTPLHIACQQGSLRSVSVLTQHCQPHHLLAVLQATNYNGHTCLHLASIQGYLAVVEYLLSLGADVNAQEPCNGRTALHLAVDLQNSDLVSLLVKHGPDVNKVTYQGYSPYQLTWGRDNASIQEQLKLLTTADLQILPESEDEESSESEPEFTEDELMYDDCCIGGRQLTF
What is the function of this protein?
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm.  May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and pro-inflammatory responses, apoptosis, differentiation and growth.  Controlled by sequential serine-phosphorylation, ubiquitination and degradation.  Tyrosine-phosphorylation could only lead to dissociation from NF-kappa-B (By similarity).
What are the official names of this protein?
NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, REL-associated protein pp40.
What is the protein family that this protein belongs to?
Belongs to the NF-kappa-B inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSG_PSE14
Sequence: MEFLPLFHNLRGSRVLVVGGGEIALRKSRLIADAGAVLRVVAPEIEAQLSELVVQSGGEMILRGYSESDLDGCVLIIAATDDEPLNAQVSHDARLRCVPVNVVDAPALCTVIFPAIVDRSPLVIAVSSGGDAPVLARLIRAKLETWIPSTYGQLAGLAARFRNQVKGLFPNVQQRRAFWEDVFQGAIADRQLAGQGAEAERLLIAKIAGEPPPETGEVYLVGAGPGDPDLLTFRALRLMQQADVVLYDRLVAPTILDLCRRDAERVYVGKRRAEHAVPQEQINQQLVALAKQGKRVVRLKGGDPFIFGRGGEEIEELAVHGIPFQVVPGITAASGCAAYAGIPLTHRDHAQSVRFITGHLKDGTTDLPWSDLVAPAQTLVFYMGLIGLPVICEELIRHGRSADTPAALVQQGTTVNQRVFTGTLANLPQLVAEHEVHAPTLVIIGEVVKLREKLAWFEGAQATV
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: PDXB_SALNS
Sequence: MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPINFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKDGPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDLNVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQRVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDETAAALLCKLGFNAVHHPAH
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_LIBAS
Sequence: MNRQGKSVEISELSKIFSSSGSIVVAHYKGISVAQIKDLRKKMREAGGGVKVAKNRLVKIAIRDTSIRGISDLFVGQSLIVYSDSPVIAPKISVSFSNDNNEFRVLGGVVEKGVLNQDSIKQIASLPDLEGIRAGIISAIQSNATRLVRLLGTPQTQVVRAISAFVDKNQQG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RUTF_CROTZ
Sequence: MSEQQAFRDAMSRLGAAVNIVTTDGPAGMAGFTASAVCSVTDSPPTLLVCLNRNASVWPVFQANGQLCVNTLAAGHEALSGLFGGKTPMEERFAAARWRRGVTGSPQLDGAVVSFDCRVEQVVPVSTHDVLLCRVLEITRNDDTHGLVWFDRHYHALSRPVCGLAS
What is the function of this protein?
Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.
What are the official names of this protein?
FMN reductase (NADH) RutF, FMN reductase, NADH-flavin reductase RutF, NADH:flavin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
Protein: YIDD_JANSC
Sequence: MNPAAFLISLPIRFYRLVISPMIASNCRYTPTCSSYAMEALRKHGAIKGTWLAARRVSRCHPWGGSGIDNVPD
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YQGF_DESAP
Sequence: MRLMGLDIGDRRIGVALTDENGVAAYPLEVLERTSPEKDLRRITEIIDQYGVERVVAGLPKTLSGQIGPQGDKVLSFLDKLRVRSTVPVITWDERLTTAEVEKLLVSADLGRRRRRKVVDKLAATLILNSYLNSRKSGRNT
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOI_RHILO
Sequence: MMSALSQAAKSLLLQDFVSAFFLSMRQFFAPKETINYPHEKGPVSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNISLDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KU_HELMI
Sequence: MIVRSIWKGAISFGLVHIPIKLFAATEEKDVRFHLLHKECHNPIQYQKRCPYCDREVTPEEIVKGFEYDKGRYVIITQEELEGLAPEGSRSIDIQSFVALKEIDPIFFVKTYYLSPDQHGQKAYALLRNALRETDRLALARVILRTKEALVALRVYGKGLAMHTMLYPEEIRSMEPLGDLGESIEVSAKEQTMAVQLIESLTEPFDPVKWQSEQRERIRHFINAKVQGQAIVEAPQTPTVGKVIDLMEALKASIQQVKTQQKKEAAPKKERRRKTS
What is the function of this protein?
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity.  Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA.  Recruits and stimulates the ligase activity of LigD.
What are the official names of this protein?
Non-homologous end joining protein Ku.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic Ku family.
Protein: RF2_ECOBW
Sequence: MFEINPVNNRIQDLTERSDVLRGYLDYDAKKERLEEVNAELEQPDVWNEPERAQALGKERSSLEAVVDTLDQMKQGLEDVSGLLELAVEADDEETFNEAVAELDALEEKLAQLEFRRMFSGEYDSADCYLDIQAGSGGTEAQDWASMLERMYLRWAESRGFKTEIIEESEGEVAGIKSVTIKISGDYAYGWLRTETGVHRLVRKSPFDSGGRRHTSFSSAFVYPEVDDDIDIEINPADLRIDVYRTSGAGGQHVNRTESAVRITHIPTGIVTQCQNDRSQHKNKDQAMKQMKAKLYELEMQKKNAEKQAMEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVETRNTQAVLDGSLDQFIEASLKAGL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCS1_SYNE7
Sequence: MTSDPLASPSFADRWRRGQQLFWTWLADLRLAILLLLAIAIASATGTVIEQGQSLAFYQENYPTDPALFGFLSWRWILSLGLDHVYRAGWFLGLLILFGASLTACTFRRQWPALRAAQRWQFYQEPRQFTKLALSASLPQGKLDSLEPLLLQRRYRLFRADDVLYARRGLAGRVGPILVHAGMLVVLGGAIWGSLGGFYAQEMIPSGETFQVRNIVDAGPWSGSRIPQDWAVKVNRFWIDYAPDGRIDQFYSDLSVVDREGQEQDRQTIHVNQPLRYGGLTFYQADWAIAAAQVRLNNSPVLQLPMAQLPAAGRIWGTFVPTKPDLSSGVSLIAKDLQGTAVIYGSNGEPLGTLRKGMAIEVEGIRLSLVDLVGSTGLQIKSDPGIPWVYAGFLFVMVGVVCSYVSHAQVWALEQDGQLYIGGRSNRALVAFEQEMLAVLAQLDAQSNHSAETAIA
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsB.
What is the protein family that this protein belongs to?
Belongs to the Ccs1/CcsB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: MENA_HAEIN
Sequence: MRSKKMINEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSNFANDYGDHQKGSDTEERIGPLRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVGGTYYLQTHSIDSHIILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYLAFAVATAISWTNYLFVLAMPLLAKHAIFVYCSQQPSELRPILAQMSMISLLINILFSLGLLIG
What is the function of this protein?
Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
What are the official names of this protein?
1,4-dihydroxy-2-naphthoate octaprenyltransferase, DHNA-octaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MenA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MATK_MORIN
Sequence: MAEFQGYLELDRSWKHDLLYPLIFREYIYVFAHDLGLNRSNLLENVGYDNKSSLLIVKRLISRMYQQNHFIISANDSNQNQLFGYNKNLYSQMISEGFAVIVEIPFSLRLVSSLKGTEIVKYYNLRSIHSIFPFLEDKFSQLNYVSDVLIPYPIHLEILVQTLRYWVKDASSLHLLRFFLHDYYNWNTLIIPNKYISIFSKSNPRLFLFLYNSHVCEYESILLFLRNQSSHLRLTSSGGFFERIYFYGKIKHPVEEVFANDSPTSLWFLEDLFMHYVRYQGKSILASKDTPLFMNKWKYYLVLLWQCHFYVWSQPGRMYINQLCKHSFSFLGYLSSMQINLSVVRSQMLENSFLMDNAMKKIDTLVPISLLIGSLDKMKFCNVLGHPVSKSTWADSSDFDIIDRFVCICRNLFHYYSGSSKKKSLYRIKYILRLSCVKTLARKHKSTVRTFLKKLGSNLLEEFFTEEEEVLSLIFPRTYSALRRSYKGRIWYLDIFCINDLVNHK
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RIMM_RUMCH
Sequence: MLEYLIVGQLINTHGVKGELKATSQTDDPQRFKKLKWVYIDKNGSLEKYDINGVKFFKQFIIIKFQGVDSIEEAEKLKGFYIKVDRANAVKLPENSFFISDIIGLKVYDENNQLLGELKDVIQTGSNDVYVVRDSDSKEILIPALKSVVKEVSIEEGKISVILPKGLLD
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGF22_HUMAN
Sequence: MRRRLWLGLAWLLLARAPDAAGTPSASRGPRSYPHLEGDVRWRRLFSSTHFFLRVDPGGRVQGTRWRHGQDSILEIRSVHVGVVVIKAVSSGFYVAMNRRGRLYGSRLYTVDCRFRERIEENGHNTYASQRWRRRGQPMFLALDRRGGPRPGGRTRRYHLSAHFLPVLVS
What is the function of this protein?
Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis.  Can stimulate cell proliferation (in vitro).  May be involved in hair development.
What are the official names of this protein?
Fibroblast growth factor 22, FGF-22.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYC_ESCF3
Sequence: MLKIFNTLTRQKEEFKPIHAGEVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLRFLGYKLKYVRNITDIDDKIIKRANENGESFVALVDRMIAEMHKDFDALNILRPDMEPRATHHIAEIIELTEQLIAKGHAYVADNGDVMFDVPTDPTYGVLSRQDLDQLQAGARVDVVDDKRNPMDFVLWKMSKEGEPSWPSPWGAGRPGWHIECSAMNCKQLGNHFDIHGGGSDLMFPHHENEIAQSTCAHDGQYVNYWMHSGMVMVDREKMSKSLGNFFTVRDVLKYYDAETVRYFLMSGHYRSQLNYSEENLKQARAALERLYTALRGTDKTVAPAGGEAFEARFIEAMDDDFNTPEAYSVLFDMAREVNRLKAEDMVAANAMASHLRKLSAVLGLLEQEPEAFLQSGAQADDSEVAEIEALIQQRLDARKAKDWAAADAARDRLNEMGIVLEDGPQGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCY2_MAJSQ
Sequence: GQLALKQQTVNRLLNKIYSPISDAYSELKQL
What is the function of this protein?
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
What are the official names of this protein?
Hemocyanin subunit 2.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: RECO_NOCSJ
Sequence: MLYRDEAIVLRTHKLGEADRIVTLLTRQRGRVRAVAKGVRRTTSRFGSRLEPFTHVDLQLAEGRNLDTITQAETLTPFSKGLGLDYDRYTAGTVMLETADRLVAEEREPSVQQFLLLVGGLRAMVAGEHAPGQVLDSYLLRSLAVAGYAPSFEHCARCGTLSAEGAHRWFNPSMGGMLCSTCRVPGSASPAPETVALLGALLAGDWAVVDPAAARNLKEASTLVAAYLAWHLERGLKSMAYVER
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: DRP1D_ARATH
Sequence: MESLIVLINTIQRACTVVGDHGGDSNALSSLWEALPSVAVVGGQSSGKSSVLESIVGRDFLPRGSGIVTRRPLVLQLHKTENGTEDNAEFLHLTNKKFTNFSLVRKEIEDETDRITGKNKQISSIPIHLSIFSPNVVNLTLIDLPGLTKVAVEGQPETIVEDIESMVRSYVEKPNCLILAISPANQDIATSDAMKLAKEVDPIGDRTFGVLTKLDLMDKGTNALDVINGRSYKLKYPWVGIVNRSQADINKNVDMMVARRKEREYFETSPDYGHLATRMGSEYLAKLLSKLLESVIRSRIPSILSLINNNIEELERELDQLGRPIAIDAGAQLYTILGMCRAFEKIFKEHLDGGRPGGARIYGIFDYNLPTAIKKLPFDRHLSLQSVKRIVSESDGYQPHLIAPELGYRRLIEGSLNHFRGPAEASVNAIHLILKELVRKAIAETEELKRFPSLQIELVAAANSSLDKFREESMKSVLRLVDMESSYLTVDFFRKLHVESQNMSLSSPTSAIDQYGDGHFRKIASNVAAYIKMVAETLVNTIPKAVVHCQVRQAKLSLLNYFYAQISQSQGKRLGQLLDENPALMERRMQCAKRLELYKKARDEIDAAVWVR
What is the function of this protein?
Putative microtubule-associated force-producing protein.  Has a GTPase activity (By similarity).
What are the official names of this protein?
Phragmoplastin DRP1D, Dynamin-like protein 1D, Dynamin-like protein DLP3, Dynamin-related protein 1D, AtDRP1D.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Protein: ZFYV1_PONAB
Sequence: MSAQTSPAEKGLNPGLMCQESYACSGTDEAIFECDECCSLQCLRCEEELHRQERLRNHERIRLKPGHVPYCDLCKGLSGHLPGVRQRAIVRCQTCKINLCLECQKRTHSGGNKRRHPVTVYNVSNLQESLEAEEMDEETKRKKMTEKVVSFLLVDENEEIQVTNEEDFIRKLDCKPDQHLKVASIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHYTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRKLGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSCGVGCKNSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYEGGEEVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPAWTSLSVMTGKGPLC
What is the function of this protein?
Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity).  Regulates the morphology, size and distribution of LDs (By similarity).  Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity).  Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity).
What are the official names of this protein?
Zinc finger FYVE domain-containing protein 1.
What are the subcellular locations of this protein?
Golgi apparatus. Golgi apparatus, Golgi stack. Endoplasmic reticulum. Preautophagosomal structure. Lipid droplet. Mitochondrion. Note=Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum. During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localizes to lipid droplets in the presence of oleic acid (By similarity).
Protein: TAX_HTL1A
Sequence: MAHFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQFLIPRLPSFPTQRTSKTLKVLTPPITHTTPNIPPSFLQAMRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGGSVVCMYLYQLSPPITWPLLPHVIFCHPGQLGAFLTNVPYKRIEELLYKISLTTGALIILPEDCLPTTLFQPARAPVTLTAWQNGLLPFHSTLTTPGLIWTFTDGTPMISGPCPKDGQPSLVLQSSSFIFHKFQTKAYHPSFLLSHGLIQYSSFHSLHLLFEEYTNIPISLLFNEKEADDNDHEPQISPGGLEPPSEKHFRETEV
What is the function of this protein?
Transcriptional activator that governs the viral transcription from the 5'LTR via the recruitment of dimers of host phosphorylated CREB1.  Together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription (PubMed:8970957).  Increases host CREB1 O-GlcNAcylation to further increase 5'LTR transactivation (PubMed:28742148).  Modulates also the expression of cellular genes leading to the deregulation of T-cell proliferation, perturbing the integrity of cell cycle checkpoints, the DNA damage response and apopototic pathways.  Acts as an ubiquitin E3 ligase and stimulates host IKK complex by catalyzing the assembly of free mixed-linkage polyubiquitin chains, resulting in constitutive activation of the transcription factor NF-kappa-B (PubMed:28103322, PubMed:27082114).  Inhibits the host nonsense-mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs by interacting with host UPF1 (PubMed:27082114).
What are the official names of this protein?
Protein Tax-1, Protein X-LOR, Protein PX, Trans-activating transcriptional regulatory protein of HTLV-1.
What is the protein family that this protein belongs to?
Belongs to the deltaretrovirus Tax protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Shuttles from the host nucleus to the cytoplasm. Found predominantly in the nucleus, where it is equally distributed between the nucleoplasm and the nuclear matrix.
Protein: TRPB_POLSJ
Sequence: MFDYHQPDPTGHFGIYGGSFVSETLTHAINELKDAYAKYQNDPEFLAEFHSELAHFVGRPSPIYHAARMSREQGGAQIYLKREDLNHTGAHKINNTIGQAMLARRMGKTRIIAETGAGQHGVATATICARYGLECVVYMGSEDVKRQSPNVYRMKLLGATVVPVESGSKTLKDALNEAMRDWVANVDNTFYIIGTVAGPHPYPMMVRDFQSVIGTECLAQMPEFIGNRQPDAVIACVGGGSNAMGIFYPYIAHEETRLIGVEAAGEGLESGKHSASLQRGLPGVLHGNRTYVLQNDDGQVTETHSISAGLDYPGVGPEHAFLKDIGRAEYVGITDTEALEAFHYLCRTEGIIAALESSHAVAYAMKLAKTMRSDQSILVNLSGRGDKDIGTVADLSGADFYDRPSMRGLAVKGGEQPKEFSDGPPLGKLAPSGGSAVREATSVGARK
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: TMBL2_PYRFU
Sequence: MSKDRMVELLQEHFELNLYEARAYVALVAFGVLTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGKTNKYRPVHPANVLEKFIQDWQERVKEELEAKKKAKEELLELMAPLIETEVPKYGVERVWVVRGIKNSTLKTKEMLEEAQNEILLADDGFIAVNLEDDIIKAVDRGVKTKILLTKNLLPRLKASKIIDYAKEGKLELRALDKFDLPMLICDEEVFFALEDLAARYFNYETQVWIKDHRVVALFKEKFNEYWEKAEKV
What is the function of this protein?
Binds to the maltodextrin transport gene cluster (mdxE operon) promoter and to some other TGM (Thermococcales-Glycolytic-Motif) sequences, but not exclusively.
What are the official names of this protein?
Putative HTH-type transcriptional regulator TrmBL2.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulator TrmB family.
Protein: NDUA9_SOLTU
Sequence: ASNLATGGAGPLIXKGTGGRSS
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, Complex I-38.5kD, CI-38.5kD, NADH-ubiquinone oxidoreductase 38.5 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA9 subunit family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CYAY_RICRS
Sequence: MNNSEFSKIAETTIAYIAEKIEEQDKEASIDVDLQGDILNLDTDKGVYVINKQSAAKEIWLSSPVSGPYHFFYEQGKWTNRAGLELMAILTEELNIKFDTRPT
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.