PharMolix/UniProtQA huggingface dataset:
Protein: M2_I01A2
Sequence: MSLLTEVETYVLPTRNEWECRCSGSSDPLVVASSIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: PYVH_ASPV1
Sequence: MASSRIVELATRISENTAIVDAYLRENQLPSPSFDEDGPVDFAIQGEEVKKAHEEAIALSWELHRLLLGPSHFLRPVPNGLSLQAISKHDIATKVPVHGKISYAALAQQCGLSEINTRRFVRYAIVHHRVFCEPQPGYVAHSAASRLLAEDPVMRDVLSHYLEECFPSFAMTLRAIDQFQDNGEPNQTGWNLYHETQDAPWDYYETHPAMARRFASTMAYETEREGRSSNVLVEGYAWTSLLAETTATTTSPLVVDVGGSRGKTALEIAHAHPELTLLVQDLPSMIEGARDQLPAIPARERVQFMAHDFFAPQLVPADAYILRHVFHNWSDRNAVRILRALVPSLQPGARLIVNDYIAPVPGVLSLAKEQRLREMDLIMLTLCNAYEREEQDWKRLFQEADPRFHVRTMSVPKGATEGILEVIWEG
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of pyranoviolin A, a pyranonigrin analog with a C-3 methoxy group (PubMed:33117309).  Initially, the PKS portion of pyvA synthesizes C-10 carbon chain from 5 molecules of malonyl-CoA, which is then condensed with the thiolation (T) domain-bound glycine activated by the adenylation (A) domain (PubMed:33117309).  The subsequent chain release by Dieckmann condensation (DKC) could be catalyzed by the TE domain present at the C-terminus of pyvA and/or the alpha/beta hydrolase pyvD, installing the tetramic acid moiety (Probable).  The FAD-dependent monooxygenase pyvC next epoxidizes one of the olefins of the polyketide part, and the epoxide ring-opening induces the dihydro-gamma-pyrone ring formation (Probable).  The cytochrome P450 monooxygeanse pyvB would be responsible for the 2 consecutive reactions, in which the dihydro-gamma-pyrone is oxidized to gamma-pyrone and C-7 is hydroxylated to yield pyranonigrin F (Probable).  Finally, the O-methyltransferase pyvH methylates the C-3 hydroxy group to complete the biosynthesis (Probable).
What are the official names of this protein?
O-methyltransferase pyvH, Pyranoviolin A biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: CYOE_PECAS
Sequence: MIKQYLQVTKPGIIFGNLISVIGGFLLAAQGRIDYPLFLATLVGVSLVVASGCVFNNVIDRDIDKKMERTKNRVLVKGLISLKVTLVYASLLGIAGFALLYVAANPLAMWLAVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVSNQFDAGALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIVAFAIATLMLSLGGYAGYKYLIVAAAVSVWWLGMALSGYKNAIDDRVWARKLFVFSIVAITSLSVMMSVDSMAPAHEVLLTYLR
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FTHS_SHEB8
Sequence: MLTDMNISSRASLKNITELGADLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVTAVTPTPHGEGKTVTSIGLTQSLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQEMNLHLTGDIHAVSSAHNLGAAAIAARLFHEARLGKKEFEAQSGQAFLAIDPNEIRWHRVVDHNDRCLRQIHVGLGDNNGPEYESSFDITAASELMAILALSHDLADMRARIGRLVLALNTQGQVITADDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDIALRLADFVVTEGGFGSDMGFEKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSNVSNIHVPNINATNINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDSDAELQWLMEAVNASAAFGCEISDAFSQGEAGAIALAQTVVRAAETESQFKLLYPDEVSLEAKLSTLAEVGYGAAGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVRELVLHAGAGFITALVGNVMTMPGLGLKPGYLKIDIDAKGEIVGLG
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: ACTPG_OULOR
Sequence: GAIIAGAALGFNVHQTVLKALGQVSRKIAIGVDNESGGTWTALNAYFRSGTTDVILPEFVPNQKALLYSGQKDTGPVATGAVGVLAYYMSDGNTLGVMFSVPFDYNLYSNWWDVKVYRGRRRADQAMYEGLLYGIPYGGDNGWHARKLGYGLKGRGFMKSSAQSILEIHVTKA
What is the function of this protein?
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and cytolysis.  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers.  Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts.  Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects (By similarity).
What are the official names of this protein?
DELTA-actitoxin-Oor1b, DELTA-AITX-Oor1b, Actinoporin Or-G, Cytolysin Or-G.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: ACYP_MOOTA
Sequence: MSLVRAHFLVKGFVQGVGFRYFVLRQAAALQLNGWVRNRYNGSVEGVVEGPEAEVKEFLDRCRRGPAWAEVKEVKVQYEEPRGETTFRIRSSV
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: ENSA_XENLA
Sequence: MSDKYIGDSHLEETGEEKQDSQEKEAVTPEKAEEQKLKAKYPNLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKIKNKQLPCAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGHVEDLHHV
What is the function of this protein?
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.  When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.
What are the official names of this protein?
Alpha-endosulfine.
What is the protein family that this protein belongs to?
Belongs to the endosulfine family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF15_LOBMA
Sequence: MLLLKHGRIEILDQNTMYGWYELPKQEFLNSEQPELLLTT
What are the official names of this protein?
Putative uncharacterized protein ycf15, Orf77.
What is the protein family that this protein belongs to?
Belongs to the ycf15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYY_UREP2
Sequence: MHSLIKDLKARNLINNITNEEKLIKALEKNKGIYVGFDPSADSLHLGNYIMIMLLKRFRLYNIKTLALVGGATGMIGDPSGKSAERNLLDKTILEKNIAKIKFQLEKFTNSQVINNYVFYENMTFLDFLRDVGKLININYLLEKEIINSRLSVGISYTEFSYNLLQGYDFLQLYKNDNIAIQAGGSDQWGNITTGIEMIRKNLGDDNIACGLTINLLTNSEGKKFGKSEKGAIYLDENKSTVYEMYQFLINQSDADVEKLLNFLTLIDVEEIKKIMQAHKNNPALRVAQKALAKAVVVDIHGQQKYEQALHISEVLFNGSISTLNQEELEIAIKSLPATKLDKDEIKIIDLLNLANISSSNRIARDFLNTGSILINDIKINDENFLVKKQDAINQKFSIIRKGKRNYFLILWNKD
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCP_STRPM
Sequence: MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADVLQQHIESFQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPIRADGKAAYFSTLPIKAMVAAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAKAGFMHIPFMMEQVVDKPNTAAMNLDDITRGIEAAIFAIVDFKDRSDLKRVGGATH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_THEMA
Sequence: MKVGVALSGGVDSAVALYLLLKEGHEVKAFHMKTKEDEFFIKKEIKKKVCCSPSDTADAMRIAHFLGVEIEIVDVKEIFREKVIEPFKRDLLKGLTPNPCAHCNRFVKFGYLMDYVLNQGFDAFASGHYARIEFSEKYGRKVIKKGVDLKKDQSYFLARIEPWRIERLIFPNGIYTKEEIRKIAEEAGIHVAKKQESQDVCFIPDGSIENFLKDEGITLKDGDIITPEGEVVGRHFGYPLYTIGQRKGFKIEKFGRRYYVRGKIPEKNVVVVSDLEDVFFSGLIAEDPVWHVEVPEEFRCVCRVRKKSEEAPAVVKVKDNEVEVSFEKKVFAVTPGQIAAFYDGDTLLGGAIIKEGIR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGI1_CANGA
Sequence: MAKKDKKPKVNTIVTKDGESLKVFEDLNDFEMFIKNETEDEEFDHIHCKLTYYPPFVLHESHDDPEKIKDTNNSHNKKFVRHLHQHVEKHLLKDIKEALHKPELKFHDKSKDETFEHIVWHYGEETEYHDRKFRIQVTVTCNHDDAMVDVDYKTIPL
What is the function of this protein?
Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
What are the official names of this protein?
Respiratory growth induced protein 1.
What is the protein family that this protein belongs to?
Belongs to the RGI1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y1725_DICDI
Sequence: MGKGELELAGFILSEAFDEKAEKEKVEKEKALKEKTEKEKAEKEKAEKEKVEKEKAEKEKAAKEKAAKEKAEREKSKSAVSPATTNQNSNKGNVEKGVAIGVLAGGAVTGVAVGGAYLADKYIASKAAGAAVNVIELTPIPNAANTANNAAAVSQGSHRWQPLPYYLFNI
What are the official names of this protein?
Putative uncharacterized transmembrane protein DDB_G0293028.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PURQ_DEHM1
Sequence: MSKVKTLILRTPGTNCDIETSYAFELAGSETEMVHINELLAKPSRLAEFQIMAFPGGFGYGDDLGAGRVLANEVRLKLGEKINRFHESGGLIIGICNGFQALVKTGILPGPMKDGQKITLTENNSGRFECRWTYLAVNPFSTCVFTQGIDRLYLPVAHGEGKLLGSPEVINKLNSVVYYTDKDGKRNSPYPANPAGTLMDIAGIADESGRIFALMPHPERFVRGSQHPRWPAEGLKEEGDGLKIFTNAVKWARQV
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAGX_STAA8
Sequence: MRFTIIIPTCNNEATIRQLLISIESKEHYRILCIDGGSTDQTIPMIERLQRELKHISLIQLQNASIATCINKGLMDIKMTDPHDSDAFMVIKPTSIVLPGKLDRLTAAFKNNDNIDMVIGQRAYNYHGEWKLKSADEFIKDNRIVTLTEQPDLLSMMSFDGKLFSAKFAELQCDETLANTYNHAILVKAMQKATDIHLVSQMIVGDNDIDTHATSNDEDFNRYITEIMKIRQRVMEMLLLPEQRLLYSDMVDRILFNNSLKYYMNEHPAVTHTTIQLVKDYIMSMQHSDYVSQNMFDIINTVEFIGENWDREIYELWRQTLIQVGINRPTYKKFLIQLKGRKFAHRTKSMLKR
What are the official names of this protein?
Putative glycosyltransferase TagX, Teichoic acid biosynthesis protein X.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: ATP6_PROM0
Sequence: MFFNSLLTNFAALEVGQHLYWQIGNIRLHGQVFLTSWILLGALLVFISLGTKKMENDPKGLQNLLEFLWDYIRDLARTQIGEKVYRDWMPFIGTLFLFVFVSNWGGALIPWRLIKLPSGELGAPTADINTTIALALLVSLSYFYAGLSNKGWRYFEYYVHPTPIMLPFKILEDFTKPLSLSFRLFGNILADELVVGVLVFLVPLILPIPVMFLGLFTSAIQALIFATLAAYYIGEAVEEHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: ASPG_HELPY
Sequence: MAQNLPTIALLATGGTIAGSGASASLGSYKSGELGIKELLKAIPSLNRLARIQGEQISNIGSQDMNEEVWFKLAKRAQELLDDSRIQGVVITHGTDTLEESAYFLNLVLRSTKPVVLVGAMRNAASLSADGALNLYNAVSVALNEKSANKGVLVVMDDNIFSAREVIKTHTTHTSTFKALNSGAIGSVYYGKTRYYMQPLRKHTTESEFSLSQLKTPLPKVDIIYTHAGMTPDLFQASLNSHAKGVVIAGVGNGNVSAGFLKAMQEASQMGVVIVRSSRVNSGEITSGEIDDKAFITSDNLNPQKARVLLQLALTKTNNKEKIQEMFEEY
What are the official names of this protein?
Probable L-asparaginase, L-ASNase, L-asparagine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBID_SPHTD
Sequence: MTTIAVVPVQRLSTAKSRLAARLAPDERRTLVLSLLDHVLTALNAARQVDAVILVSPDPEVLEHAARRGAIALLQPGVGLNEGLRLGRDEALRRGADTLLIVLADLPWITADEIDALVAALPERGIALAPDRHDHGTNAAALRPPDAIEPAFGAGSFARHQAQARSRGLPLRELRVQGLAFDIDTPADLEELAGHAPVGASSDESGT
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
Phosphoenolpyruvate guanylyltransferase, PEP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: Y5855_DICDI
Sequence: MIMITIKLGRDYTQDLINKCGRGGVGGGGLNGIFLSYEGVV
What are the official names of this protein?
Putative uncharacterized protein DDB_G0285945.
Protein: RLMN_COREF
Sequence: MATPLPLVFSAPKRGMPPAHFADLSDEQRIEALSELGLPKFRLNQIARHYYGRLEADPMTMTDLPEAARAKVKDALFPTLMEPIRVVEADDENTQKTLWKLHDGTLLESVLMRYPDRATLCISSQAGCGMACPFCATGQGGLDRNLSVGEIVDQVRNAAATMQAEGGRLSNIVFMGMGEPLANYKRVVSAVRQITQPSPEGFGISQRSVTVSTVGLAPAIRKLADEDMSVTLAVSLHTPDDELRDELVPVNNRWSVAEVLDAARYYADKSGRRVSIEYALIRDVNDQGWRADMLGQKLHKALGSRVHVNLIPLNPTPGSKWDASPRERQDEFVRRVIAQGVPCTVRDTKGQEIAAACGQLAAEENSEEK
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_SHESR
Sequence: MSDKIRTLQGRVTSNKMDKTITVAIERQVKHPIYGKYIKRTTKIHAHDEANQCNEGDVVAIRECRPLSKTKSWTLVEVVSKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RL1_PSESM
Sequence: MAKLTKRQKAIAEKIEAGKSYNFVDAAALLTELSTVKFSESIDVAVNLGVDPRKSDQVVRSATVLPHGTGKTVRVAVFTQGPAAEAALAAGADRVGMDDLAAEMKAGDLNYDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPDVATAVKNAKAGQVRYRTDKNGIIHTSVGKVGFDAVKLKENVEALIADLKRIKPASSKGIYVKRITLSTTMGPGLVIDQGSLEA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: CR108_PHYSO
Sequence: MVKLYCAVVGVAGSAFSVRVDESDTVDDLKDAIKAKKPNDFKDIDADKLELYVAKRDGVWLTEADVKSGVADITGLVRLEVVRAKLFSVGLSDEVVSEVDAQEEAAGRGPVNVLVVVPMKKRRVDAGVDEERRFFDTRDFPPLLAPPQRGATVESPEAQWEKLLNSLEWKEPKRLCASSGQNWPYQGESELAGHLVEPLALHYTAWYLQNEDKQNHAINLVLSGPGTGKSRMLDQMKGLMCAAAARSNNRKLKERMENAFVFSVTFENGTSATGSLLDRDNPEFDISYRMLYQLSKDRPNWKKFAKTLKSYRSLELDIEAAIGILAKLKGIDDVKKMTVILCVDGLQKLVNDGTKSCDFYRVLASVCSFLNSSRAFAVCVCSATIQSPVDKALSDSPQKRVFLVPPPLRGHEVLPTKTRIEKQLVDDMGGHGRALETLQLFLSHYTKDQLEEMDPTWMFEKVCDALRLQYGDIFASPFFQDPYNCREVLAAILSRRRYKLFDRIGRTDMTVDCLRSFGLFRWGAEGHLECAFILLVLLMQKLPKKLGEVDNFDDHLTRTVLVWQRFEQFVAFYRRVKSIAYCETPVALSSFHAGARFGAIQDIIITEPTSRTVVEALRQEDTKSSSDDSTCFTNRDGGVKISDMDTIVINGASASAGDLFMRVQLKVGRQNVQCNEVIQCKLLQTKQKIHEDAYAKERAKAANESSDVFLLVTPAQATEFDLPPRCGLVSANEFGRYFGPFTSRAYRSFLEPPNINTASFHELRRLEGVGDATAAKIIAERTIRRFSNLEDALNRLVPSKKGKTAMILSRMHYDDDEADL
What is the function of this protein?
Secreted effector that suppresses plant basal defense and promotes plant susceptibility via targeting promoters of host HSP gene and thus inhibiting their expression.  CRN108 binds directly to heat shock elements (HSEs) 5'-GAAnnTTC-3' and interferes with the association of the HSE with the plant heat shock transcription factors, which initializes HSP gene expression in response to stress.
What are the official names of this protein?
Crinkler effector protein 108.
What is the protein family that this protein belongs to?
Belongs to the Crinkler effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: RLMN_PROM3
Sequence: MSSTHLPGGNQALLGCSATELESWAVAEGQPAFRGRQLHDWLYAKGARSFDAITVLPKSWRISLQQRGLTIGRLLEVNRAVAVDDTTKLLLATVDGETIESVGIPTQQRLTVCLSSQVGCPMACRFCASGKGGLQRSLATHEIVDQVLSLREAMDRRPSHVVFMGMGEPLLNIEAVLASIRCLNIDLGIAQRRITVSTVGVPHTLPQLAELAMKRLGRAQFTLAVSLHAPNQELRERLIPTACAYPFETLLQDCRHYLAVTGRRVTFEYILLGALNDQPQHAEELAERVRGFQSHVNLIAYNPIDDEGFQRPNPETIEAFRRVLEQRGVAVSLRASRGLDQNAACGQLRRQHAAIG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SGO1_ORYSJ
Sequence: MAAAAGAAARGGGVIPAGKGGSLRSPGKPVVLADITNTGRPNPTGSVHAIADVLKENAKLRHLLAERNKVIEVSRVELQKIRLALQAMQQKNLQLVQANSQMFAEINQGKDRIKLLQHELACTIAVLKVKGSELEKMSKTSNNQQNRAKILEKKTRSSKCAPTKAHQMAAGSIREHLVEIQSAVPSYTSCHEPPQDKTNKRCTNRRKSESCEVTMDTNTVQHSCRPHVEYNGSSHDDDPRKTRRRRSARLNPGSFEVAEICDKLHEDATVPSAPSSNVPKLQEPNAGKDMICGGKMKSLQKELPCDAIAQVVEAPELKEIQEAGSSVAGGEAHKFDIEDPEPPRKSMRIDANKRKLESFESRLASNKEDCINAICDSTSSVPIQHEQKRKLSRRKSSRLDPGPWEVTNGTFEIVQEDTVAPSAPSSSNALIEQTKNDMQNDRSCSTKPSDEQVIGRRSSVGRPSRRAAEKIVSYKEVPLNIKMRRP
What is the function of this protein?
Plays a central role in chromosome cohesion during meiosis I by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.  Required for the timely assembly and maintenance of synaptonemal complex (SC) during early prophase I.  Required for maintenance of centromeric cohesion before prophase II and correct segregation of chromatids during meiosis II.  Has apparently no function in mitosis.
What are the official names of this protein?
Shugoshin-1, OsSGO1.
What is the protein family that this protein belongs to?
Belongs to the shugoshin family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome, centromere. Note=Transfers from nucleoli onto centromeric regions at the onset of prophase in both mitosis and meiosis. AM1 is required for centromeric localization.
Protein: OPSD_SARSL
Sequence: MNGTEGPYFYVPMVNTSGIVRSPYEYPQYYLVNPAAYARLGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWLMALACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFTVPLMVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIMMVVAFLVCWLPYASVAWWIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTASKTEASSVSSSSVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: IF1C_ADICA
Sequence: MKKQNLIDMEGTVTESLPNATFRACLDNGCQVLTHISGRMRRSYIRILPGDRVRVELSPYDLTKGRIIYRLRSRHTNNSQ
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.