PharMolix/UniProtQA huggingface dataset:
Protein: CDK18_MOUSE
Sequence: MNKMKNFKRRLSLSVPRPETIEESLAEFTEQFNQLHTQTNEDGTDEPEQLSPGMQYQQRQNQRRFSMEDLNKRLSLPMDIRLPQEFLQKLQLENPGLPKPLTRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSLLLYESKSRMSAEAALNHPYFQSLGDRVHQLHDTASIFSLKEIQLQKDPGYRGLAFQHPGRGKSRRQSIF
What is the function of this protein?
May play a role in signal transduction cascades in terminally differentiated cells.
What are the official names of this protein?
Cyclin-dependent kinase 18, Cell division protein kinase 18, PCTAIRE-motif protein kinase 3, Serine/threonine-protein kinase PCTAIRE-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: RS2_WOLTR
Sequence: MNMANLPEVTVRDLARSGVHFGHKISRWNAKMAPYIYGVHQENRIHIIDLRKTLPLLQAAMKVLYNVAFQGGRILFVGTKFQALDIIASEAIRCGQYYVNYRWLGGMLTNWGTISSSIKTLVQYEKVLNAENSILTKKELGNIEKKRQKLDKALGGIREMGAVPDVLFIIDTNKEHIAVKEAEKLEIPVVAILDTNSDPDGITYPIPGNDDSRKSIELYCRLAADSILAGMESSLARSGVKVGDIKDEEFIQEKGDSIIRTKKGRSKVYKEDEKEVVTNEDESR
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: VG13_EHV2
Sequence: MFGVAKPPPSPIPKPPRGRHFGEKYPESVNFPSRGARQRASTRHRPSIKEVWEPPAPPGAGMIFWGENGENGDFGQSAPSCYERRRARSQGGQGAENAAPVLRPGPEGRRRRESLIFLEGDMVRETATVAPWTVSPLRPERPKSLLGRFRSRLTVWREVPRTPGPVAPIPELPGEADDPPTRTPPPPPDD
What are the official names of this protein?
Protein E6C.
Protein: KLOM_LUMTE
Sequence: LGYITCPGSNLGTLR
What are the official names of this protein?
Lombricine kinase, LK.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: RUVA_BDEBA
Sequence: MIGYLRGKIIEVMNDSALIDVSGVGYEIHASSNTLGDLQALLGNDIIVWIHTHVREDALQLFGFHDKEEKNLFLSLLKVNGVGPKMALSILSGGRPAQIHEMIEAGNAKALSGLPKVGKKTAEQIILTLKGKLVSIEEGGVVAKAKSVAHTQITSALLNLGYKSQLVDQFVSSLPADIAVEDGIRKGFQTLSGGLS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: SEPA_EMENI
Sequence: MPTSDKSRQTSAGKSFFGRKLHKERPVEDRWDAHGSWESLAPPSSAAGSRSSRYSKRSSIQSVDFGADIDPSLLSTSAGPITSIPFESLSTDTQSPIPVDYLSKAETSPRKEPSPGHLAKGVGDFHQYPAWDPSAMRNHQQFSHPTGPRPPPHAAGVAMSSSATGDKGARYQQWGRPGSSAGNAGLSHHSSSTVDSSTNSRMSIDQASIHSSLSSNTRGSSYISTDGSSRTTLPSHSNDRSNYYAAMNSGRGSSAQGAIPPAQPRVQNTEQYLTRPRDDRVVDQLFLELMQKRGWQNLPEQARRQMMAYPASKKWTLVHQDRLTELQGEQKRKQKARETHGYDGPSGILERADEEGSPEWYVKKVMDDTITSKQLASLSVSLRTQPISWVKAFVEAQGQIALTNVLVKINRKKVTGPVPAPPSGDKDLDREYDIVKCLKALMNNKYGADDALAHQQIIVALISSLLSPRLNTRKLVSEVLTFLCHWAEGQGHERVLQAMDHVKNHQGETGRFDAWMRIVEVTIDGRGKMGSLVGASEEYRSGGIGMENLLMEYAVSTMILINMLVDAPENDLQLRCHIRAQFISCGIKRLLSKMEGFQYEVIDKQIEHFRENEAIDYEDLLQRESSSTKDSIEGEVKDMTDPLQITDAIASRLNGTRAHDYFLSALQHLLLIRENSGEDGLRMYQLVDAMLSYVAMDRRLPDLDLRQGLTFTVQSLLDRLHTDAEARRAYDESLEARQIAEAALAERDEMKAQVELGADGLVRKLQKQIEEQTGIIELQSRQNEMLKAELADVQRLRAQELQRNELETRELYLMLRDAQDIAASNAKKSNMGEAETDPAHMRGILDREKLLTRLEKQLERTKTQFKLEGKVWGQHDPSDRLRELREQMDGDAGPREAFEEQARLNLSLNPVGSVYRKKTYIQGMEDTATEELGQTDDEVVYAKARLVDLHRPRMDPEQATGLLGEIAAKVPKIDADDAKDEGKPTESEQPAEGAATKGDEQGVDDTVAVDKATAAPPPPPPPPPAHPGLSGAAPPPPPPPPPPPPGAGAAPPPPPPPPPPPPGGLGGPPPPPPPPPPGGFGGPPPPPPPPGGFGGPPPPPPPPPGGAFGVPPPPPPPGTVIGGWRANYLASQGAPSHAIPVMSSIRPKKKLKALHWDKVDTPQVTVWATHGTTPQEKEEKYVELAKRGVLDEVERLFMAKETRIFGGGVAAKQRKDKKQIISNDLSKNFQIALSKFSQFPAEEVVRRIIHCDAEILDNMVVMEFLQRDEMCTVPENVSKLMAPYSKDWTGPDAANTEREQDPSELTREDQIYLYTAFELNHYWKARMRALALTRSFEPDYEHISAKLREVVRVSESLRDSVSLMNVLGLILDIGNFMNDANKQAQGFKLSSLARLGMVKDDKNETTFADLVERIVRNQYPEWEDFTEQISGVIGLQKLNVDQLRTDAKKYIDNIKNVQASLDAGNLSDPKKFHPQDRVSQITQRSMKDARRKAEQMQLYLEEMVKTYDDIMVFYGEDNTDDGARRDFFAKLAAFLQEWKKSKEKNIALEEARRRTEASLARKRINVGLANGAGAAGDAPVSPATSGAMDSLLEKLRAAAPQAKDQRDRRRRARLKERHQVRVASGQKIPDLEGAEAPGSGGQNSGATDTNATDSSLLSPTIQEPEGGSSPIASQSEDVADRAASMLQDMLRNSPDPERTRRRRESAEEERRKRRLRRRNGATSGSKDSNDTTPLSPVTEPTSTQGESAEPENLSLSSPPNGEDPTLNPPTIVLSSDASDTPDDEHRPSTS
What is the function of this protein?
Involved in cytokinesis.  Overexpression results in growth inhibition.
What are the official names of this protein?
Cytokinesis protein sepA, Forced expression inhibition of growth A, Protein FH1/2.
What is the protein family that this protein belongs to?
Belongs to the formin homology family. BNI1 subfamily.
Protein: SCAP_MOUSE
Sequence: MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNAATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQQAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAGPAEGVHDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRSAWAPQEPLPAGLWESGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFETQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRVGCGRSRDSGYDFSRLVQRVYQEEGLAAMRMPALRPPSPGPPLPQASQEEGTAPEKGSPPLAWTPSTAGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSSVYSSSNTVTCHRTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLDDSCCLFTLKGHSGAITAVYIDQTMVLASGGQDGAICLWDVLTGSRVSQTFAHRGDVTSLTCTASCVISSGLDDFISIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD
What is the function of this protein?
Escort protein required for cholesterol as well as lipid homeostasis (PubMed:11358865, PubMed:9854040).  Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11358865, PubMed:9854040, PubMed:29068315).  At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity).  Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).  Binds cholesterol via its SSD domain (By similarity).
What are the official names of this protein?
Sterol regulatory element-binding protein cleavage-activating protein, SCAP, SREBP cleavage-activating protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SCAP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. Requires the presence of SPRING for proper localization to endoplasmic reticulum.
Protein: GPDA_RICFE
Sequence: MNKFKNIAVYGGGSFGTSLASLAAQNCNNVTLFLRDEEIAKEILHNKTNVKYLGDIKLPTHLQVTTNLSVIKDFELIIIAVPSYAFDDSIKLLKTHGISADNTLLIATKGFARNPTELFSDRLKTLLPHSTTAFFAGSNLAKELAKNLPASASIASLDIDIANKIANNLSSKTFTTNTTSDIVTLQVAGALKNIFAIKSGIDLAKKQGKNARATLIVTVLKEIAILSKALGGTASSRSLDTNLLLEAGVVGDLVLTCYSLGSRNTKFGYELGISSDKKIFLREYKELVEGQEALKLVLDLIKKYDLQMPIISEVANYVIPE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GALE_METJA
Sequence: MILVTGGAGFIGSHIVDKLIENNYDVIILDNLTTGNKNNINPKAEFVNADIRDKDLDEKINFKDVEVVIHQAAQINVRNSVENPVYDGDINVLGTINILEMMRKYDIDKIVFASSGGAVYGEPNYLPVDENHPINPLSPYGLSKYVGEEYIKLYNRLYGIEYAILRYSNVYGERQDPKGEAGVISIFIDKMLKNQSPIIFGDGNQTRDFVYVGDVAKANLMALNWKNEIVNIGTGKETSVNELFDIIKHEIGFRGEAIYDKPREGEVYRIYLDIKKAESLGWKPEIDLKEGIKRVVNWMKNNNRT
What is the function of this protein?
Involved in the metabolism of galactose.  Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
What are the official names of this protein?
Putative UDP-glucose 4-epimerase, Galactowaldenase, UDP-galactose 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: REP_BACAM
Sequence: MYSSENDYSILEDKTATGKKRDWRGKKRRANLMAEHYEALEKRIGAPYYGKKAERLSECAEHLSFKRDPETGRLKLYQAHFCKVRLCPMCAWRRSLKIAYHNKLIIEEANRQYGCGWIFLTLTVRNVKGERLKPQISEMMEGFRKLFQYKKVKTSVLGFFRALEITKNHEEDTYHPHFHVLLPVKRNYFGKNYIKQAEWTSLWKRAMKLDYTPIVDIRRVKGRVKIDAEQIESDVREAMMEQKAVLEISKYPVKDTDVVRGSKVTDDNLNTVFYLDDALSARRLIGYGGILKEIHKELNLGDAEGGDLVKIEEEDDEVANGAFEVMAYWHPGIKNYILK
What are the official names of this protein?
Protein rep, Replication protein.
What is the protein family that this protein belongs to?
Belongs to the Gram-positive plasmids replication protein type 1 family.
Protein: RNH_CERS5
Sequence: MSDLFAYTDGACSGNPGPGGWGVLMLAREGEAVVKERTLQGGEALTTNNRMELMAAISALEALTRPTEITIVTDSAYVKNGVTTWIHGWKRNGWKTADRKPVKNAELWERLDAAQQRHKVVWRWIKGHAGHAENERADELARAGMAPFKTR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOT8_RAT
Sequence: MALPSPASEEAEGPCQEANQEYQEPVCSPVPEPEPEPEPEPEPEPEPVPVPPPEPQPEPEPQPLPDPAPLPVLGFEAEPVQEPEPTPTVETRGTARGFQPPEGGFGWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDRIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTLRQRFLVQFRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGNYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRESSKDKMLSHDPDPNGELLPGSPTPEEPI
What is the function of this protein?
Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormone across the cell membrane independently of pH or a Na(+) gradient.  Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:12871948).  Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (By similarity).
What are the official names of this protein?
Monocarboxylate transporter 8, MCT 8, Solute carrier family 16 member 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYC_VIBVY
Sequence: MLKIYNTLTRQKEEFKPITAGKVGMYVCGVTIYDLCHIGHGRTFVSFDVVSRYLRYLGYDLTFVRNITDIDDKIIKRAAENGETCDSLTERLIGEMHADFDALNMKRPDVEPRATQYIQEIIELVERLIERGFAYVADNGDVMFEVNKFDEYGKLSKQDLDQLQAGARVDVETAKRCPLDFVLWKMSKPGEPTWESPWGPGRPGWHIECSAMNSSILGNHFDIHGGGSDLQFPHHENEIAQSCCAHDTQYVNTWMHSGMVMVDKEKMSKSLGNFFTIRDVLGHYDAETVRYFLMSGHYRSQLNYSEENLNQARASLERLYTSLRGLDFSAAPAGGEEYVSRFTAAMNDDFNTPEAYSVLFDMAREINRLKTEDLANASALGALMRELADVIGILHQDPEAFLKGDAGNDDEVAEIEALIKLRNDSRAAKDWANADMARDKLNEMGIVLEDGPDGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR2_TRACE
Sequence: MTRRYWNITLDEMMDASVHLGHDTKQWNPKMAPYIFPKCTTRKGIHLTNLFTTARFLSEACDVVFNAASRENQFLIVGTKKKAADSVLRAAIRAQCHYVNKKWLSGMLTNWSTTETRLHKFRDLRIKEKRGRLKRLPKRDAAILKRQLSHLQRSLGGIKYMTKLPDFVIIIDQQKDYTALRECIKLGIPTISLIDTNSDPDLASLSIPANDDSRSSIKFILNKLVFAIREGRYESIGNSGLKKRKRTY
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TYPH_CHRVO
Sequence: MFLPQEIIRKKRDNLTLSQQEIQQFVAGITDNSVADSQIAALAMAIYFNGMELEENVHLALAMRDSGRRMHWKDLNLPGPIVDKHSTGGVGDVVSLMLGPMVAACGGFVPMISGRGLGHTGGTLDKLSAVPGYNPFPEPELFRKVVKDVGVAIIGQTSDLAPADRRFYATRDVTATVESIALITASILSKKLAAGLDVLVMDVKAGSGAFMPTMQKSIELAERIVKVGNGAGVATTALITEMSQPLASTAGNSIETREAVRYLKGDQRNPRLHEVTMALCAQMLIGGKLAADEADARAKLQAALDSGRAAEIFGRMVTALGGPADFMEHYDRHLAPAPIMRPVYADRAGYVGAMDTRGIGMAVCALGGGRRLATDVLDFRVGLSQFVELGQNIGKDTPLMMIHAADEASFEDAARRVKAAIRIDEAAPSELPLVYQIIRGE
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: END1_BUCBP
Sequence: MLIRSIFFFTILIFSTCLSSNENIKHHYHKNFNQIKKLAQKINIDAPGTFYCGCKIFWKEKKGIPELNSCGYHIRKNANRANRIEWEHVMPAWQFGHSKSCWKKGGRKNCIHDYNYQKIETDLHNLQPVIGEINGDRSNFMYNQFPKSTLNGQYGQCSMKIDFKNKLVEPPDISKGAISRIYFYMSDFYHFKLSKKQKKLFLMWNKKYNVTNWECMRDNLIFKIQGNHNPYVYSKCQKNNTNKNI
What is the function of this protein?
Has double-strand break activity.
What are the official names of this protein?
Endonuclease-1, Endonuclease I, Endo I.
What is the protein family that this protein belongs to?
Belongs to the EndA/NucM nuclease family.
Protein: HCP2_BPLSK
Sequence: MEFDSYIDWYNNLLTMPLNDVILGVKDTIEDKTVYLSLSDSKVIKMDNTSFVMGYY
What is the function of this protein?
Probably functions as a stopper that is part of the head-tail connector and that locks the viral DNA in the capsid.  During assembly, functions as a docking platform which the preassembled tail can bind to.  Plays a role in morphogenesis of the virion capsid after genome packaging.
What are the official names of this protein?
Probable head completion protein 2, Connector protein gp9, Gene product 9, gp9, Putative stopper protein gp9, Stopper protein gp9.
What is the protein family that this protein belongs to?
Belongs to the skunalikevirus head completion protein 2 family.
What are the subcellular locations of this protein?
Virion. Note=Part of the connector between the portal and the tail.
Protein: CO6A_CONMF
Sequence: RDCQEKWEYCIVPILGFVYCCPGLICGPFVCV
What is the function of this protein?
MuO-conotoxins are gating-modifier toxins that inhibit sodium current by trapping the domain II voltage sensor in the closed position to prevent opening of the sodium channel.  This toxin shows high activity on Nav1. 4/SCN4A (IC(50)=81 nM) and Nav1. 8/SCN10A (IC(50)=96-529 nM).  It also shows low activity on other sodium channels (Nav1. 5/SCN5A, IC(50)=431-3900 nM > Nav1. 1/SCN1A, IC(50)=3. 3 uM; Nav1. 2/SCN2A, IC(50)=5. 1-6. 3 uM; Nav1. 3/SCN3A, IC(50)=2. 2 uM; Nav1. 6/SCN8A, IC(50)=1. 2-4. 6 uM; Nav1. 7/SCN9A, IC(50)=2. 3-5. 5 uM) (PubMed:22609441).  On Nav1. 8/SCN10A, it causes a small left shift in the voltage dependence of activation and the voltage dependence of inactivation (PubMed:27026701).  In addition, it has been shown to interact with lipid membranes (PubMed:27026701).
What are the official names of this protein?
MuO-conotoxin MfVIA.
What are the subcellular locations of this protein?
Secreted.
Protein: RL20_SHEPW
Sequence: MPRVKRGVTARARHKKVLKLAKGYYGARSRTYRVAVQAVTKAGQYAYRDRRQKKRQFRQLWIARINAASRQNGLSYSRFINGLKKASIEIDRKILADIAVFDKVVFTTLVEKAKEALAK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RL3_BARBK
Sequence: MRSGVITQKLGMTSIYNDTGERVPVTVLRLENCQVIAQRTVEKNGYTAVQLGVGLAKFEKTSKALRGHFSKALVEPKAKIVEFRVSSDNLLDVGTEITVEHFVPGQRVDVTGTSIGKGFAGVMKRHNFGGHRASHGNSITHRAHGSTGQCQDPGKVFKGKKMAGHMGQVRVTTQNVEVVSIDVDRGLILVRGAVSGSKGAWVLVRDAVKKRLPDNAPRPAGVRSPANVKVKPATPIAEVSVAEGVE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: LPXA_BARQU
Sequence: MSGTKIHPTALVEKGAQLGENVFIGPFCHIGPEAVIDDGCSLMNHVVIMGKTTLGAKSKVFSHAVLGTDPQNNKHKGGYTTLSIGKNCTIREGVTMHRGSDSSVGMTIVGDDCQFFCYAHVAHDCRVGSHVTFANNAMIAGHVTVGDYVIIGGGSAVHQFVRIGHHAFIGGVSALVGDLIPYGTAVGVQAKLAGLNIIGMKRAGLERKDIHALRHAVAMLFDHSKPFKERVNDVSSFYSTSQSVLDVVNFIKEEGKRFYCTPKFEDDRIKVNKD
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_CAMJ8
Sequence: MSKFKVIEIKEDARPRDFEAFQLRLASPEKIKSWSYGEVKKPETINYRTLKPERDGLFCAKIFGPIRDYECLCGKYKKMRFKGVKCEKCGVEVANSKVRRSRMGHIELVTPVAHIWYVNSLPSRIGTLLGVKMKDLERVLYYEAYIVENPGDAFYDNESTKKVEYCDVLNEEQYQNLMQRYENSGFKARMGGEVVRDLLANLDLVALLNQLKEEMAATNSEAKKKTIIKRLKVVENFLNSNLNANADSDEAVPNRPEWMMITNLPVLPPDLRPLVALDGGKFAVSDVNDLYRRVINRNTRLKKLMELDAPEIIIRNEKRMLQEAVDALFDNGRRANAVKGANKRPLKSLSEIIKGKQGRFRQNLLGKRVDFSGRSVIVVGPKLRMDQCGLPKKMALELFKPHLLAKLEEKGYATTVKQAKKMIENKTNEVWECLEEVVKGHPVMLNRAPTLHKLSIQAFHPVLVEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSQEAIAECKVLMLSSMNILLPASGKSVTVPSQDMVLGIYYLSLEKAGAKGSHKICTGIDEVMMALESKCLDIHASIQTMVDGRKITTTAGRLIIKSILPDFVPENSWNKVLKKKDIAALVDYVYKQGGLEITASFLDRLKNLGFEYATKAGISISIADIIVPNDKQKAIDEAKKQVREIQNSYNLGLITSGERYNKIIDIWKSTNNVLSKEMMKLVEKDKEGFNSIYMMADSGARGSAAQISQLAAMRGLMTKPDGSIIETPIISNFREGLNVLEYFISTHGARKGLADTALKTANAGYLTRKLIDVAQNVKITIEDCGTHEGVEINEITADSSIIETLEERILGRVLAEDVIDPITNSVLFAEGTLMDEEKAKILGESGIKSVNIRTPITCKAKKGICAKCYGINLGEGKLVKPGEAVGIISAQSIGEPGTQLTLRTFHSGGTASTDLQDRQVSAQKEGFIRFYNLKTYKNKEGKNIVANRRNAAILLVEPKIKTPFKGVINIENIHEDVIVSIKNKKQEVKYILRKYDLAKPNELAGVSGSIDGKLYLPYQSGMQVEENESIVEVIKEGWNVPNRIPFASEILVEDGEPVVQNIKAGEKGTLKFYILKGDGLDRVKNVKKGDIVKEKGFFVVIADENDREAKRHYIPRESKIEFNDSEKIDDANTIIASAPKKERKVIAEWDAYNNTIIAEIDGVVSFEDIEAGYSADEQIDEATGKRSLVINEYLPSGVRPTLVIAGKGDKAVRYQLEPKTVIFVHDGDKIAQADILAKTPKAAAKSKDITGGLPRVSELFEARKPKNAAVIAEIDGVVRFDKPLRSKERIIIQAEDGTSAEYLIDKSKHIQVRDGEFIHAGEKLTDGVVSSHDVLKILGEKALHYYLISEIQQVYRGQGVVISDKHIEVIVSQMLRQVKVVDSGHTKFIEGDLVSRRKFREENERIIRMGGEPAIAEPVLLGVTRAAIGSDSVISAASFQETTKVLTEASIAGKFDYLEDLKENVILGRMIPVGTGLYGEQNLKLKEQE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: NSP1_ROTS4
Sequence: MATFKDACFHYRRLTALNRRLCNIGANSICMPVPDAKIKGWCLECCQIADLTHCYGCSLPHVCKWCVQNRRCFLDNEPHLLKLRTVKHPITKDKLQCIIDLYNIIFPINDKVIRKFERMIKQRKCRNQYKIEWYNHLLLPITLNAAAFKFDENNLYYVFGLYEKSVSDIYAPYRIVNFINEFDKLLLDDINFTRMSNLPIELRNHYAKKYFQLSRLPSSKLKQIYFSDFTKETVIFNTYTKTPGRSIYRNVTEFNWRDELELYSDLKNDKNKLIAAMMTSKYTRFYAHDNNFGRLKMTIFELGHHCQPNYVASNHPGNASDIQYCKWCNIKYFLSKIDWRIRDMYNLLMEFIKDCYKSNVNVGHCSSVENIYPLIKRLIWSLFTNHMDQTIEEVFNHMSPVSVEGTNVIMLILGLNISLYNEIKRTLNVDSIPMVLNLNEFSSIVKSISSKWYNVDELDKLPMSIKSTEELIEMKNSGTLTEEFELLISNSEDDNE
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7.  Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.
What are the official names of this protein?
Non-structural protein 1, NSP1, NCVP2, Non-structural RNA-binding protein 53, NS53.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP1 family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton.
Protein: PUR5_XYLFA
Sequence: MTTLTSPSTTPLTYRDAGVDIDAGNTLVERIKPLVKRSFRPEVMSGLGGFGALFNLAGKYKEPVLVSGTDGVGTKLKLAQQLNRHNTIGIDLVAMCVNDVLVQGAEPLFFLDYFATGKLDIDTATAVISGIALGCEQSGCALIGGETAEMPDMYPPGEYDLAGFCVAAVEKSQLLDGSQVREGDVLIGIASSGPHSNGYSLIRRIYERAGSPADLDIHGTRLIDTLMAPTTLYVKPILKLLHTHSDAIHAMAHITGGGLTENIIRVIPPNLGLRIDANAWTQPPVFQWLQSEGALADTEMWRTFNCGIGFVLVATPNQVAPLGQALDNQGLAHWQIGRVFTPVGNERVHIG
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AWN_PIG
Sequence: MKLAAPSLALLLSTATLVSGAWNRRSRSCGGVLRDPPGKIFNSDGPQKDCVWTIKVKPHFHVVLAIPPLNLSCGKEYVELLDGPPGSEIIGKICGGISLVFRSSSNIATIKYLRTSGQRASPFHIYYYADPEGPLQFPYFDRQTIIATEKNIP
What is the function of this protein?
AWN proteins mediate the binding of boar spermatozoa to component(s) of the egg's zona pellucida by a carbohydrate-binding mechanism.  Awn proteins are secretory components of the male accessory glands being coated to the sperm surface at the time of ejaculation.  They possess as well heparin-, serine-protease-inhibitor-binding capability.
What are the official names of this protein?
Carbohydrate-binding protein AWN, Sperm-associated protein AWN, Spermadhesin AWN, Zona pellucida-binding protein AWN.
What is the protein family that this protein belongs to?
Belongs to the spermadhesin family.
What are the subcellular locations of this protein?
Secreted. Note=Predominantly localized on the membrane overlying the acrosomal cap region of the sperm head.
Protein: DSRB_ECO57
Sequence: MKVNDRVTVKTDGGPRRPGVVLAVEEFSEGTMYLVSLEDYPLGIWFFNEAGHQDGIFVEKAE
What are the official names of this protein?
Protein DsrB.
What is the protein family that this protein belongs to?
Belongs to the DsrB family.