PharMolix/UniProtQA huggingface dataset:
Protein: VME1_CVM2
Sequence: MNSTTQAPQPVYQWTADEAIRFLKEWNFSLGIILLFVTIILQFGYTSRSMFVYVVKMILLWLMWPLTIVLCIFNCVYALNNVYLGFSIVFTIVSIIMWIMYFVNSIRLFIRTGSWWSFNPETNNLMCTDMKGTVYVRPIIEDYHTLTATIIRGHLYMQGVKLGTGFSLSDLPAYVTVAKVSHLCTYKRAFLDKVDGVSGFAVYVKSKVGNYRLPSNKPSGMDTALLRI
What is the function of this protein?
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
What are the official names of this protein?
Membrane protein, M protein, E1 glycoprotein, Matrix glycoprotein, Membrane glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses M protein family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.
Protein: STRAA_MACFA
Sequence: MSFLTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLGACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISLDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPYFHHFVEQCLQPNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFESSQSQDHSGIFGLVTNLEELEVDDWEF
What is the function of this protein?
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1.  Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).
What are the official names of this protein?
STE20-related kinase adapter protein alpha, STRAD alpha, STE20-related adapter protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RLPA_VIBCH
Sequence: MNRIYLYLLIVLILAGCSSPGGRYDMSDDQAPDTPLSVEHIEDAHPQYEPYSFGGNKDYNLRGKSYRIIKNPKGFTESGKASWYGKKFHGHLTSNGEIYDMYSMTAAHKTLPIPSYVKVTNTDNGKSTVVRVNDRGPFHDGRIIDLSYAAAYKIGVVQAGTANVRIEVITVDKPTKPRPKSKNNALEYVIQVVSSQHIERVRTLAQNLGQNLSAPSFVESTNNTHRLFLGPFTDDDLTQTLLEQVKSAGYDSAFIKTINKRAK
What is the function of this protein?
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
What are the official names of this protein?
Endolytic peptidoglycan transglycosylase RlpA.
What is the protein family that this protein belongs to?
Belongs to the RlpA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: YQGF_STRPG
Sequence: MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIKIDEEKAEFGFTRLEELVKQYQVEQFVIGLPKNMNNTNGPRVDASITYGNHIEHLFGLPVHYQDERLTTVEAERMLIEQADISRGKRKKVIDKLAAQLILQNYLNRNF
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPNP_SHEB2
Sequence: MSLLEQVSVSKKANIYFDGKVASRSVFFADGSKQTLGVVQPGEYEFSTSQGEIMEVISGRFEVLLPETTTWQEFNEGTQFELAANVSFKIRNTAIAEYCCSYL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: NPLP1_AGRIP
Sequence: MNDAGASIGRHRGCLLLFVALAVAFSSYVEQVESMPAEPVSQWPTFPRRNIAALARDGYLRNSASRAYKRGISTLAKNGLLPTYRSPYVETDKEDQNQDESQEKRNMASIARLRSYAAMKRNIQALARDGYRVGRGQYNPSNDKRNIAALARNGLLHKKDEATENEYYFPFYQNPIAPLSEIDHPLDVNEMYDFQQSMNPDMFPSMSQVYKRSLYEPYYDYYSPKDYDNSYFKRSSAGSPVHGLYRPNYLEPNTRTKRYVMPYPDILEGDEMIEQNDIDGEKRSVDDDDDDDDDDGEVHENFQKRHIGSLARLGLLPSFRYSGGRYSRSGRARLLLPSQELYRKHSPDENFGIREYLSSPEVESPVDPDDADIPPPPVPAHSHPTGRLLHRPLSNDLPHTSPLPLPPIAPTNYADTFTKNRWQSYTKETPKFYYFRSLKVPYHTSGKRYLLLPAVDNILLRKGYRNSSLPSRRKNQ
What are the official names of this protein?
Neuropeptide-like precursor 1.
What are the subcellular locations of this protein?
Secreted.
Protein: BTUR_SALTY
Sequence: MSDERYQQRQQKVKDRVDARVAQAQEERGIIIVFTGNGKGKTTAAFGTAARAVGHGKNVGVVQFIKGTWPNGERNLLEPHGVEFQVMATGFTWETQNREADTAACMAVWQHGKRMLADPLLDMVVLDELTYMVAYDYLPLEEVISALNARPGHQTVIITGRGCHRDILDLADTVSELRPVKHAFDAGVKAQMGIDY
What is the function of this protein?
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids.  Participates in the adenosylation of a variety of incomplete and complete corrinoids.
What are the official names of this protein?
Corrinoid adenosyltransferase CobA, Cob(II)alamin adenosyltransferase, Cob(II)yrinic acid a,c-diamide adenosyltransferase, Cobinamide/cobalamin adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Cob(I)alamin adenosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC61G_CIOIN
Sequence: MDQVMAWVEPGKQFAKDSIRLVKRCTKPDRKEFQKIAVATAIGFAIMGFIGFFVKLIHIPINNIIVGS
What is the function of this protein?
Necessary for protein translocation in the endoplasmic reticulum and multi-pass membrane protein biogenesis.
What are the official names of this protein?
Protein transport protein Sec61 subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MAP2_METTH
Sequence: MIKMIESYLKAGKIVSKVRREAAGIIRDGLPIIELVNYVEDRIIEEGGRPAFPCNVSVNEVTAHYTSPPGDDSVIGDGDLVKLDLGAHVDGFIADTAITVPVGDVDDKCHQMMDAAREALENAISTIRAGVEVGEIGRVIEETIHSHGMNPVSNLTGHSMERWILHSGLSIPNINERNTHQLEEGDVLAIEPFATDGVGLVTDMPQTYIFRFLRERPLRLVHARRVLGKIREEYHALPFAQRWLEEYFDAKRLNASMRMLIQSRAIYPYHVLREKSGAMVAQWEHTVIVEEDGCTVITE
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
Protein: YM13B_YEAST
Sequence: MESQQLSQHSPISHGSACASVTSKEVQTTQDPLDISASKTEECEKVSTQANSQQPTTPLSSAVPENHHHASPQAAQVPLPQNGPYPQQRMMNTQQANISGWPVYGHPSLMPYPPYQMSPMYAPPGAQSQFTQYPQYVGTHLNTPSPESGNSFPDSSSAKSNMTSTNQHVRPPPILTSPNDFLNWVKIYIKFLQNSNLGDIIPTATRKAVRQMTDDELTFLCHTFQLFAPSQFLPPWVKDILSVDYTDIMKILSKSINKMQSDTQEVNDITTLATLHYNGSTPADAFEAEVTNILDRLNNNGIPINNKVACQFIMRGLSGEYKFLRYARHRCIHMTVADLFSDIHSMYEEQQESKRNKSTHRRSPSDEKKDSRTYTNTTKPKSITRNSQKPNNSQSRTARAHNVSTFNNSPGPDNDLIRGSTTEPIQLKNTHDLHLGQELTESTVNHTNHSDDKLPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQQSNDLNIESDHDFQSDIELHPEQLRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNTHESSHASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFENSQVTICLFVDDMVLFSKNLNSNKRIIDKLKMQYDTKIINLGESDEEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
What is the function of this protein?
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane.  Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
What are the official names of this protein?
Transposon Ty1-MR1 Gag-Pol polyprotein, Gag-Pol-p199, TY1A-TY1B, Transposon Ty1 TYA-TYB polyprotein, p190.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SHOC1_HUMAN
Sequence: MTDTSVLDQWKASFFVEDFLEKKTITRMVTQINCEFEEVVPSSNPDSQIEVEEVSLYTHMDYNEVFTPVSCLEKCSALQNQNQDLFIDDKGILFVSSRKHLPTLPTLLSRLKLFLVKDPLLDFKGQIFTEANFSRECFSLQETLEAFVKEDFCMDKVNFCQEKLEDTICLNEPSSFLIEYEFLIPPSLKPEIDIPSLSELKELLNPVPEIINYVDEKEKLFERDLTNKHGIEDIGDIKFSSTEILTIQSQSEPEECSKPGELEMPLTPLFLTCQHSSVNSLRTELQTFPLSPVCKINLLTAEESANEYYMMWQLERCRSPLNPFLLTVPRIQEPHSQYSVTDLKKIFSVKEESLVINLEKAEWWKQAGLNLKMMETLEHLNTYLCHDNLSSNDTKIEIFLPTKVLQLESCLEHKSHSSPIALIDEKSTNAHLSLPQKSPSLAKEVPDLCFSDDYFSDKGAAKEEKPKNDQEPVNRIIQKKENNDHFELDCTGPSIKSPSSSIIKKASFEHGKKQENDLDLLSDFIMLRNKYKTCTSKTEVTNSDEKHDKEACSLTLQEESPIVHINKTLEEINQERGTDSVIEIQASDSQCQAFCLLEAAASPILKNLVSLCTLPTANWKFATVIFDQTRFLLKEQEKVVSDAVRQGTIDEREMTFKHAALLHLLVTIRDVLLTCSLDTALGYLSKAKDIYNSILGPYLGDIWRQLEIVQFIRGKKPETNYKIQELQCQILSWMQSQQQIKVLIIIRMDSDGEKHFLIKILNKIEGLTLTVLHSNERKDFLESEGVLRGTSSCVVVHNQYIGADFPWSNFSFVVEYNYVEDSCWTKHCKELNIPYMAFKVILPDTVLERSTLLDRFGGFLLEIQIPYVFFASEGLLNTPDILQLLESNYNISLVERGCSESLKLFGSSECYVVVTIDEHTAIILQDLEELNYEKASDNIIMRLMALSLQYRYCWIILYTKETLNSEYLLTEKTLHHLALIYAALVSFGLNSEELDVKLIIAPGVEATALIIRQIADHSLMTSKRDPHEWLDKSWLKVSPSEEEMYLLDFPCINPLVAQLMLNKGPSLHWILLATLCQLQELLPEVPEKVLKHFCSITSLFKIGSSSITKSPQISSPQENRNQISTLSSQSSASDLDSVIQEHNEYYQYLGLGETVQEDKTTILNDNSSIMELKEISSFLPPVTSYNQTSYWKDSSCKSNIGQNTPFLINIESRRPAYNSFLNHSDSESDVFSLGLTQMNCETIKSPTDTQKRVSVVPRFINSQKRRTHEAKGFINKDVSDPIFSLEGTQSPLHWNFKKNIWEQENHPFNLQYGAQQTACNKLYSQKGNLFTDQQKCLSDESEGLTCESSKDETFWRELPSVPSLDLFRASDSNANQKEFNSLYFYQRAGKSLGQKRHHESSFNSGDKESLTGFMCSQLPQFKKRRLAYEKVPGRVDGQTRLRFF
What is the function of this protein?
ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity).  Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103).  Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103).  Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (By similarity).  Required for proper synaptonemal complex assembly and homologous chromosome pairing (By similarity).  Requiref for recruitment TEX11 and MSH4 to recombination intermediates (By similarity).
What are the official names of this protein?
Protein shortage in chiasmata 1 ortholog, Protein ZIP2 homolog, MZIP2.
What is the protein family that this protein belongs to?
Belongs to the XPF family. Highly divergent.
What are the subcellular locations of this protein?
Chromosome. Note=Localizes to meiotic chromosomes; associates with mid-stage meiotic recombination intermediates. Localization requires meiotic double-strand breaks (DSBs) recombination intermediates catalyzed by DMC1.
Protein: QUEF_ECOK1
Sequence: MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKVSVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATSGEKVVEETLVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AB25B_ARATH
Sequence: MSRGSRFVRAPGLLLCRVNLQPQPKIPSFSYSLRSDYRLHNGFSNYIRRNSIRTSPVINAFLSDNSPSPSPSPSPIRFVQRSSMLNGRLFSTSTPNPDQTTTKTKEIKTTSSDSDSAMADMKILRTLAGYLWMRDNPEFRFRVIAALGFLVGAKVLNVQVPFLFKLAVDWLASATGTGASLTTFAATNPTLLTVFATPAAVLIGYGIARTGSSAFNELRTAVFSKVALRTIRSVSRKVFSHLHDLDLRYHLSRETGGLNRIIDRGSRAINFILSAMVFNVVPTILEISMVSGILAYKFGAAFAWITSLSVGSYIVFTLAVTQWRTKFRKAMNKADNDASTRAIDSLINYETVKYFNNEGYEAEKYDQFLKKYEDAALQTQRSLAFLNFGQSIIFSTALSTAMVLCSQGIMNGQMTVGDLVMVNGLLFQLSLPLNFLGSVYRETIQSLVDMKSMFQLLEEKSDITNTSDAKPLVLKGGNIEFENVHFSYLPERKILDGISFVVPAGKSVAIVGTSGSGKSTILRMLFRFFDTDSGNIRIDGQDIKEVRLDSLRSSIGVVPQDTVLFNDTIFHNIHYGRLSATEEEVYEAARRAAIHETISNFPDKYSTIVGERGLKLSGGEKQRVALARTFLKSPAILLCDEATSALDSTTEAEILNALKALASNRTSIFIAHRLTTAMQCDEIVVLENGKVVEQGPHDELLGKSGRYAQLWTQQNSSVDMLDAAIKLE
What is the function of this protein?
Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins.  Not required for mitochondrial and plastid Fe-S enzymes.  Probably involved in the export of cyclic pyranopterin monophosphate (cPMP) from mitochondria into the cytosol.  Mediates glutathione-dependent resistance to heavy metals such as cadmium and lead, as well as their transport from roots to leaves.  Regulates nonprotein thiols (NPSH) and the cellular level of glutathione (GSH).
What are the official names of this protein?
ABC transporter B family member 25, mitochondrial, ABC transporter ABCB.25, AtABCB25, ABC transporter of the mitochondrion 3, AtATM3, Iron-sulfur clusters transporter ATM3, Protein STARIK 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GPMB_YERPS
Sequence: MLQVYLVRHGETLWNAARRIQGQSDSPLTEIGIRQAHLVAQRVRNQGITHIISSDLGRTQQTAKIIADACGLTMVTDPRLRELNMGVLENRPIDSLTPEEEQWRKQMVNGTEGARIPEGESMTELGRRMHAALDSCLELPAGSKPLLVSHGMALGCLLSTLLGLPAHAERRLRLRNCSLSRVDYQESPWLASGWVIESAGDTAHLDMPALDELQR
What are the official names of this protein?
Probable phosphoglycerate mutase GpmB, PGAM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. GpmB subfamily.
Protein: CCD93_RAT
Sequence: MGLPKGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCSFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSISQFQKTYSLPEDDDFIKRKDKAIQTVVDLSDAYKPRRKYRRQQGAEELLDEESRVHSTLLEYGRRHGFSRQSKTEKAEDKKTALAAGLSAAEKTDAHEEDELQAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYEGKQSELSAEESPEKLGTSQLHQRKVISLNKQILQKTKHLEELQANHTSLQAKYSDKKKTLTELKNHGEKLDQEQAALEKLEAKADPSILQNLRALVAMNESLKSQEQEFKAHCREEMARLQQEIEILKAERAPGEKTISSGEPQGALTSTMTHNEDLDRRYNMEKEKLYKIRLLQARRNREIAILHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLNSIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLEKQRLYFKTVKEFKEEGRKNELLLSKIKAKAS
What is the function of this protein?
Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels.  The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1.  Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C.
What are the official names of this protein?
Coiled-coil domain-containing protein 93.
What is the protein family that this protein belongs to?
Belongs to the CCDC93 family.
What are the subcellular locations of this protein?
Early endosome.
Protein: ILVC_THESQ
Sequence: MAVIYYDKDADLNLIKDKKIAIIGYGSQGHAHALNLKDSGLNVVVGLREGSKSWKKAEEQGLTVKTIEEAAKEADIIMILIPDEHQPEIYKKYIEKHLTEGKMLMFAHGFNIHYHQIIPPKNVDVTMIAPKSPGHIVRREYVEGRGVPALVAVYQDYTGKAKDIALAYAKGIGVTRAGVIETTFKEETETDLFGEQAVLCGGVTALIKAGFETLVDAGYQPEIAYFECLNELKLIVDLIYEGGLSFMRYSVSNTAEYGDYISQEKIVTKEVRENMKQMLKDIQTGKFAKDWILENQAGRPYFYTMRKKESEHLIEKVGKELRKMMPWLKERNVDEE
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ZDH17_HUMAN
Sequence: MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15489887, PubMed:15603740, PubMed:24705354, PubMed:27911442, PubMed:28757145).  Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).  Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145).  Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed:24705354).  Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity).  May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793).  May play a role in Mg(2+) transport (PubMed:18794299).  Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity).  Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (PubMed:27911442).
What are the official names of this protein?
Palmitoyltransferase ZDHHC17, Acyltransferase ZDHHC17, DHHC domain-containing cysteine-rich protein 17, DHHC17, Huntingtin yeast partner H, Huntingtin-interacting protein 14, HIP-14, Huntingtin-interacting protein 3, HIP-3, Huntingtin-interacting protein H, Putative MAPK-activating protein PM11, Putative NF-kappa-B-activating protein 205, Zinc finger DHHC domain-containing protein 17.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Presynaptic cell membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.
Protein: H41_BLEJA
Sequence: MGGKGGKGGKGLGKVGAKKRHRRVIRENIQGITKPAIRRLARRGGVKRTLSGLVYDETRNVLKVFLENVVRDAVTYTEHARRKTVTALDVVYALKRQG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4-1.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PYRF_STRP8
Sequence: MKEERPIIALDFSSFEETKAFLDLFPAEEKLYVKIGMELYYAQGPDIVRYIKSLGHNVFLDLKLHDIPNTVRAAMAVLKELDIDMATVHAAGGVEMLKAAREGLGQDPTLIAVTQLTSTSEDQMRGDQNIQTSLLESVLHYSKGAAKAQLDGVVCSAQEVEAIKAVTPTGFTCLTPGIRPKGSNIGDQKRVMTPNQARRIESDYIVVGRPITQAKDPVAAYQAIKAEWAG
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: TPS3_COFAR
Sequence: MISSLNPLFTTHRSGVIAQQFFASSAAASINSVSSLKIAACSKTKLVDQSPLRQSGNHQLLSSDFNHLQSLKNDYAEEKYKSRCEVLKEQVKMMLDQEMDVVNQLELIDDLQRLGLSYHFGDEITSVLSGIYNRKSMNKMRNQWGLYATCLEFRLLRQHGFDVSQEIFDCFKDEKGDFRPSLCEDSKGMLYLYEASYLESENEESNLEMARRFAAKTLKKNLDEKRVDQDLVALVQHALELPLHWRMMRLEARWFIDIYEERSNRNPILLELAKLDFNIVQAAHQNDLTYTLRWWRSTCLAEKLTFARDMMVENFFWTVGIISDPQRGNGRRILTKVVALITAIDDIYDCYGTLDELEVFTTAVERWDVNSIDQLPDCMKICFLALYNFVNEMAYDALKEQGVNIIPYLRKSWADLCKAYLQEAKWFFSGEVPTLQQYLNNAWISISAPAFLVHAYFCVDYPINKDHLQYLDNYHKIIRCSAMILRLTNDLGTSPESEVLNVGDVPKSIRCYMKETGACEEKAREHLRFLITEAWKQMEEAQTLDSPFSSTFNGIAVNLARMGLCMYQHGDGHGHQNSEPRDRILSLLFEPICCLA
What is the function of this protein?
Monoterpene synthase (mono-TPS) involved in the biosynthesis of monoterpenes natural products, constituent of coffee beverage aroma (PubMed:23398891).  Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) into linalool and beta-myrcene, and, as minor products, cis-ocimene and trans-ocimene (PubMed:23398891).  Not able to use geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP) as substrates (PubMed:23398891).
What are the official names of this protein?
Linalool synthase TPS3, chloroplastic, Cis-ocimene synthase TPS2, chloroplastic, Myrcene synthase TPS3, chloroplastic, Trans-ocimene synthase TPS2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsb subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BSHB1_BACAN
Sequence: MSGLHILAFGAHADDVEIGMAGTIAKYTKQGYEVGICDLTEADLSSNGTIELRKEEAKAAARIMGVKTRLNLAMPDRGLYMKEEYIREIVKVIRTYKPKLVFAPYYEDRHPDHANCAKLVEEAIFSAGIRKYMPEVPPHRVESFYHYMINGFHKPNFCIDISEYVSQKVEALEAYESQFSTGSDGVKTPLTEGYVETVVAREKMFGKEVGVLYAEGFMSKKPVLLHADLIGGCK
What is the function of this protein?
Involved in bacillithiol (BSH) biosynthesis.  Catalyzes the second step of the pathway, the deacetylation of N-acetylglucosaminylmalate (GlcNAc-Mal) to glucosamine malate (GlcN-Mal).
What are the official names of this protein?
N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1, GlcNAc-Mal deacetylase 1.
What is the protein family that this protein belongs to?
Belongs to the PIGL family.