PharMolix/UniProtQA huggingface dataset:
Protein: 3NO28_BUNFA
Sequence: MKTLLLTLVVVTIVCLDLGYTLTCLICPERYCQKVHTCRGEEKLCVKRFYDEKALGWRAKRGCAATCPEAKPKETVECCSTDKCNK
What is the function of this protein?
Binds with low affinity to muscular (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and very low affinity to neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR).
What are the official names of this protein?
Neurotoxin 3FTx-8a, 3FTx-VIIIa.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Ancestral subfamily. Orphan group II sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y01H_BPT4
Sequence: MKVLKKMLEWFNRPNSMYIDDGWVEQANKEMQNESEEWMKSMISAEKEKKLERSALKLMRDIYGDKS
What are the official names of this protein?
Uncharacterized 8.1 kDa protein in modB-mrh intergenic region.
Protein: RU1C_CANLF
Sequence: MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR
What is the function of this protein?
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome.  SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing.  The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.  Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
What are the official names of this protein?
U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C, U1C.
What is the protein family that this protein belongs to?
Belongs to the U1 small nuclear ribonucleoprotein C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPD_AZOSB
Sequence: MTITAQQALQRTIEHREIFFDEMLSLMRQIMAGEVSPVMTAAILTGLRVKKETIGEITAAATVMRELATKVVVPPPHDHFIDVVGTGGDGSHTFNISTATIFVTAAAGARVAKHGNRSVSSKSGSADALEALGANIMLTPEQVAECVQATGIGFMFAPSHHSAMKNVAPVRREMGVRTIFNILGPLTNPAGAPNTLLGVFHPDLVGILVRVMERLGANHVLVVHGLDGMDEVSLGAATMVGELKDGEVSEYEIHPEDYGLAMVGSRNLRVEDADESRRVLVGALENQPGPAREIVIFNAGVALYAANLVDSIEAGIVRARELVASGAARAKLDEYVQFTRKFGGA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: GLPK_XANAC
Sequence: MEKQYVLAIDQGTTSSRAMLFDRQGKVAGVAQREFGQIFPQPGWVEHNPREIMTSVYTTITELLNNAQIDARAIAGIGITNQRETAVVWDKATGQPIYNAIVWQSRQTKDICAQLKEAGHEQMVRDKTGLLIDAYFSGTKVKWILDHVEGARERAQKGELAFGTIDSWLIWNLTGGKVHVTDYTNASRTMMFNIHTLQWDAELLAMLDVPAQMLPEVRSSSEVYGMTQTQYFYGEQVPIAGIAGDQQAALFGQACFEPGMAKNTYGTGCFMLMNTGDKAVASKAGLLTTIAWGIDGKVEYALEGAIFVAGSVVQWLRDGLRMLGKASDSQAYAERAGDNDGVYIVPAFVGLGAPYWRSDIRGAVFGLTRGTTKEHFVRAAVESMAYQTRDVLTAMQSDSGIELKELRADGGAIANDFMAQFQSDILNVPVLRPEVAETTALGAAYLAGLATGFWSSREEIAKQWAVDRRFEPAMADDKRQALYAGWQQAVEATMGFRIS
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: LEPA_WOLTR
Sequence: MDNVRNFAIIAHIDHGKSTLADRLIEECNGLEAREMTNQVLDSMDIERERGITIKAQTVRLNYTANDGNRYCLNLMDTPGHVDFSYEVSRSLAACEGSLLVIDSSQGVEAQTLANVYKAIDNNHEIIVVLNKVDLPASDPERVKLQVEEIIGIGSSESILISAKTGLGIRDVLEAIITKLPAPQGNINAPLQAILVDSWYDPYLGVVILVRVKNGVLKKGMKIVMMSNNAVYQVDNIGIFTPKKVMTSELSAGEVGFITASMRKMADCKVGDTITEEKKPCGEALPGFKEIHPVVFCSIFPNKTDGFKYLREALEKLHLNDTSFTFEAETSNALGYGFRCGFLGMLHLEVIQERLEREFDLDLTATAPSVIYEVTTQSGETLNIHNPNDMPDSVKIKIVEEPWITATIMVPDQYLGEILSLCDERRGKQEDLSYVGNTMTALLKYKLPLSEVVLDFYDRLKSISKGYASLDWEISNYQESQIDKLSFLVNGEPVDALACIVHKSRSEKRGREICARLRDLIPRQQYKIAIQATVGGKIVARETINPYRKDVTAKLYGGDVTRKMKLLEKQKKGKKRLYSVGNVDIPHNAFIQALKIGD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: A57_VACCC
Sequence: MEREGVDYHYVNREAIWKGIAAGNFLEHTEFLGNIYGTSKTAVNTAAINNRICVMDLNIDGVRSFKNTYLMPYSVYIRPTSLKMVETKLRCRNTEANDEIHRRVILAKTDMDEANEAGLFDTIIIEDDVNLAYSKLIQILQDRIRMYFNTN
What are the official names of this protein?
Guanylate kinase homolog.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
Protein: RSMH_ECOSM
Sequence: MMENYKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAKTIDDPRFSIIHGPFSALGEYVAERDLIGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTRGQSAAEWLQTAEEADIAWVLKTYGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLNVLAPGGRLSIISFHSLEDRIVKRFMRENSRGPQVPAGLPMTEEQLKKLGGRQLRALGKLMPGEEEVAENPRARSSVLRIAERTNA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAPB2_HAEI8
Sequence: MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system (PubMed:27672196).  Neutralizes the effect of cognate toxin VapC2 but not non-cognate toxin VapC2 (PubMed:27672196).
What are the official names of this protein?
Antitoxin VapB2, NTHi VapB2.
What is the protein family that this protein belongs to?
Belongs to the VapB family.
Protein: LINC_SPHIU
Sequence: MSDLSGKTIIVTGGGSGIGRATVELLVASGANVAVADINDEAGEAVVAASGGKAAYFRCDIAQEEDVKALVAQTLAAFGGLDGAFNNAAIPQAGLPLAEVSLERFRQSMDINVTGTFLCMKYQILAMIERGTKGSIVNTASAAGVVGVPMHGEYVGAKHAVVGLTRVAAADYGKHGIRVNALVPGAVRTPMLQRAMDNDAGLEPYLNSIHPIGRFSEPHEQAQAAVWLLSDAASFVTGSCLAADGGFTAI
What is the function of this protein?
Catalyzes the dehydrogenation of 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-DDOL) to 2,5-dichlorohydroquinone (2,5-DCHQ), a step in the degradation of gamma-hexachlorocyclohexane (gamma-HCH or lindane).  Has an essential role in this assimilation pathway that allows S. japonicum UT26 to grow on gamma-HCH as the sole source of carbon and energy.
What are the official names of this protein?
2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase, 2,5-DDOL dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RS5_CALS8
Sequence: MVQKRIDPKELNLKERVVNINRVAKVVKGGKRLKFSAIVVVGDENGHVGAGHGKAAEIPDAIRKAIEDAKKHLIEVPIVGTTIPHEAIGDFGASKVLIKPAPEGTGVIAGGAVRAVCELAGIKDIRTKSLGSNNPANVVHATIEALKQLKKPEEVARLRGKTLEEIIK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: ARLY_PARP8
Sequence: MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIISADDLAAIQRGMAQIQGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGDLLKGLRSALLDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYVEMFSRDAERMLDTRKRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRDFAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKSENMRGAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKVCDDRGCDLSDLTLDEMKAELPNVAALLGDDVFGYLTLEGSVASRNHAGGTAPDQVRAAIAAARAALG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSP32_CAEEL
Sequence: MPNAECRHNAGFWSAAYAEMPISKFTAYAENAVLPKRKMDGISAYADMPKKIFGGICRYAVMPKNSECRTGMIQTQPGTKIVFNAPYDDKHTYHIKVINSSARRIGYGIKTTNMKRLGVDPPCGVLDPKEAVLLAVSCDAFAFGQEDTNNDRITVEWTNTPDGAAKQFRREWFQGDGMVRRKNLPIEYNP
What is the function of this protein?
Central component in molecular interactions underlying sperm crawling.  Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
What are the official names of this protein?
Major sperm protein 32, MSP.
What are the subcellular locations of this protein?
Cell projection, pseudopodium. Cytoplasm, cytoskeleton.
Protein: API1_MYCTU
Sequence: MVARHRAQAAADLASLAAAARLPSGLAAACARATLVARAMRVEHAQCRVVDLDVVVTVEVAVAFAGVATATARAGPAKVPTTPG
What is the function of this protein?
Effector protein that participates in the suppression of macrophage apoptosis by blocking the extrinsic pathway.  Recognizes the host polypyrimidine tract binding protein-associated splicing factor (PSF), which probably leads to its cleavage, diminishing the level of caspase-8 in macrophages.
What are the official names of this protein?
Apoptosis inhibitor Rv3654c.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Note=Is secreted into the macrophage cytoplasm. Might be secreted via a type IV pili apparatus that seems to be encoded in the same operon.
Protein: FLBE_CAUVC
Sequence: MTDIPHRKFAFDTVFDDHGGVAYTAPRVKKSFTPEEVEAAKAQAYAEGERSALVRTEQEAAQALAEVAHAVQQAFGTLAHVAHEHREGSAMLALACGRKIADAALTHFPEAPVTAALEALAREVEAQPRIFVRVSPELEERTQQALENVAAQIGFQGQIVARADGAMAPAAFTFDWGDGRAAFDPDGAAQRVAEALEAAIAAEGLHAEPLFT
What are the official names of this protein?
Protein FlbE.
Protein: COAD_PHODP
Sequence: MTTRVIYPGTFDPITNGHLDLIERAAAMFDTVIVGVAYNPTKKPLFDLNERVALAQSVTQHLPNVEIVGFSGLLVNFAKEHNANVLVRGLRAVSDFEYEFQLANMNRRLMPELETVFLTPAEENSFISSTIVKEVALHKGDVSQFVPNQISQALNKKLFA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_HV1S1
Sequence: MRVKGIRKNYQHLWRGGTLLLGMLMICSAVEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEIVLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLHCTNLKNATNTKSSNWKEMDRGEIKNCSFKVTTSIRNKMQKEYALFYKLDVVPIDNDNTSYKLINCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGSGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEGVVIRSENFTDNAKTIIVQLKESVEINCTRPNNNTRKSITIGPGRAFYATGDIIGDIRQAHCNISGEKWNNTLKQIVTKLQAQFGNKTIVFKQSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTIGPNNTNGTITLPCRIKQIINRWQEVGKAMYAPPIRGQIRCSSNITGLLLTRDGGKEISNTTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVTLGAMFLGFLGAAGSTMGARSLTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDQIWNNMTWMEWEREIDNYTNLIYTLIEESQNQQEKNEQELLELDKWASLWNWFDISKWLWYIKIFIMIVGGLVGLRIVFTVLSIVNRVRQGYSPLSFQTRFPAPRGPDRPEGIEEEGGERDRDRSSPLVHGLLALIWDDLRSLCLFSYHRLRDLILIAARIVELLGRRGWEALKYWGNLLQYWIQELKNSAVSLFDAIAIAVAEGTDRIIEVAQRIGRAFLHIPRRIRQGFERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: RUBR_CLOPA
Sequence: MKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQFEEVEE
What is the function of this protein?
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide.  Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
What are the official names of this protein?
Rubredoxin, Rd.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
Protein: AGALA_ASPCL
Sequence: MHPSMTLLAILPPLVRASIGNPHLLPTPPMGFNNWARFMCNLNESLFLDTAAAMLDTGLHAAGYTRLNLDDCWMASHRAPNGSLPWDPTKFPHSLPWLSAQLRSLGFSLGIYQDAGNVTCGGYPGSYGFEELDAHTFAEWGVDYLKLDGCNVSPAGAVSLADEYRARYARWHSVLGAMPHPLVFSESAPAYFVDPQNATAWYGVMDWVPAYGELARHSTDILVYEGEGSAWQSIMVNYRYNTLLARYQRPGYFNDPDFLIADHPGLSLVEKRSHFALWASFGAPLIISADVPGLSKEVIAVLTNADLIRVDQDALGLQATLASRSEHLDVLTRSLDGGDRLVTILNRGDGGLAVKVPVGWMGLQRCAYQAKNLWDGEIQEIEEDIEVQLDSHATEVFRVSLPPDCPMVIPTGIVFNTASGNCLTDGEALAFEPCRGQDLQVWQVEESGILRPLSRTSHCLTAIGDNVVVKPCTGRPGQRWTYHITGNLQNQHTGACLTEGTGIDVCGFELDSQVFGLPSGVDIEA
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase A, Melibiase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL11_SHEON
Sequence: MAKKIDAYIKLQVKSGSANPSPPVGPALGQKGVNIMEFCKAFNARTEKMEKGMPIPVVITVYSDRSFTFETKTPPASYLLKTAAGLKSGSPRPNTQKVGTIARAKIQEIAEMKAADMTGADVEAMTRSIEGTARSMGLVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ARLY_PROM2
Sequence: MAKVWSKRFDNALDPFIEKFNASIGFDRKLILEDLDCSIAHAKMLGKTQVLTSSESSQIINGLELIKVEYLEGKFSPGLPSEDIHYSIEEKLISLIGETGKKLHTGRSRNDQVGTDIRLWLRKEIDKIEILITDLQKSFFNIAKSNIYTLIPGYTHMQRAQPLSLAHHLLAYIEMLQRDRERFKEVRARVNISPLGAAALAGTKIKIDRQFTASELGFEKIYKNSIDAVSDRDFCIEFVSASALSMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVYGHLQALLTMVKGVPLSYNKDFQEDKEPIFDTAETISSCMKAMTILINEGIEFNIKNLSDSVENDFSNATDLADYLVGKDVPFRTAYQVVGEIVKYCLKRKMLFKNLKIGEFKKFHPEFDEDVFSDLKPHNVVKSRNSEGGTGFVQVEKELNHWQKKLLL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUS2_PANTR
Sequence: MAALRALCGFRGVAAQVLRPGAGVRLPIQPSRGVRQWQPDVEWAQQFGGAVMYPSKETAHWKPPPWNDVDPPKDTIVKNMTLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRLLNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLMDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTAEEALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity).  Essential for the catalytic activity and assembly of complex I (By similarity).  Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (By similarity).  Plays an important role in carotid body sensing of hypoxia (By similarity).  Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial, Complex I-49kD, CI-49kD, NADH-ubiquinone oxidoreductase 49 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ITPK3_ARATH
Sequence: MKLTDNEEITMNGTREMETTEQETSSPCSLVIEAFPVKKSIIVGYALTSKKIKSFLQPKLEGLARNKGILFVAIDQNKPLSEQGPFDIVLHKQIGKEWRRILEEFRLAHPDVTVLDPPDAILHLRNRQSMLQCVADMNLSDSNGRVGVPKQLVIKKDASSIPEAVNNAGLRLPLVAKPLVADGSAKSHELSLAYDQHSLLKLEPPLVLQEFVNHGGVLFKVYIVGEAIRVVRRFSLPDVSRRELPKSAGVFRFPRVSCAAASADDADLDPSIAELPPRPLLERLAKELRRGLGLRLFNLDIIREHGTRDRFYVIDINYFPGYGKMPEYEHVFTDFLLSVVQSQCKKRALADQY
What is the function of this protein?
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.  Phosphorylates Ins(3,4,5,6)P4 to form InsP5 (PubMed:17698066).  This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not (By similarity).  Also phosphorylates Ins(1,3,4)P3 or a racemic mixture of Ins(1,4,6)P3 and Ins(3,4,6)P3 to form InsP4 (PubMed:17698066).  Ins(1,3,4,6)P4 is an essential molecule in the hexakisphosphate (InsP6) pathway (By similarity).
What are the official names of this protein?
Inositol-tetrakisphosphate 1-kinase 3, Inositol 1,3,4-trisphosphate 5/6-kinase 3, AtItpk-3, Inositol-triphosphate 5/6-kinase 3, Ins(1,3,4)P(3) 5/6-kinase 3.
What is the protein family that this protein belongs to?
Belongs to the ITPK1 family.
Protein: Y1094_STAHJ
Sequence: MVKESIPKEGENIKIQSYKHDGNIHRVWSETTILKGTDHVIIGGNDHTLVTESDGRTWITREPAIVYFHSEFWFNVICMFREDGIYYYCNLSSPFVCDEEALKYIDYDLDIKVYPNGKYHLLDEDEYEQHMNQMNYPHDIDVILRRNVDILQQWIEQKKGPFAPDFIKVWKERYKKIRNY
What are the official names of this protein?
UPF0374 protein SH1094.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: BIOW_SULAA
Sequence: MKEYFSVKMRASLQGRHVSGAERIVLKEDLPTVISQLSQRPKEYDSLNIKVEKINDLNYIEKSLNVKTINVKDWIEGNKVAVEILQNQGVDKKIAEKYINLIHQGAVNGENMRGAMIVNLSGERVEKDKTRGIRTVNIDFEDRKAITELLKEKGYTERTVDALALATKTLNHPDIVAEYCISDDPSYTTGYVATKTTYYRINPLKQLSNEKGGRIYFVKDTANIEDIYQYLESEAFLIKQLGDLQ
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: DMP5_ARATH
Sequence: MSALRLRNANTPAPELDELSDQTPSESRVLKRQMSMSQRAMSNTLTSAANLSNLLPTGTLLAFQLLTPVFTSNGVCDHATRFLTAVLLFLLAASCFVSSFTDSVKADDGTIYFGFVTFKGMWVVDYPDPSGLGLPDLAKYRMRFVDWIHATLSVLVFGAVALRDKYITDCFYPSPEAETKHVLDIVPVGVGVMCSLLFMVFPARRHGIGYLVTGSVDRR
What is the function of this protein?
Involved in membrane remodeling.
What are the official names of this protein?
Protein DMP5, AtDMP5.
What is the protein family that this protein belongs to?
Belongs to the plant DMP1 protein family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SP2AB_BACCZ
Sequence: MRNEMNLQFSALSQNESFARVTVAAFIAQLDPTMEELTEIKTVVSEAVTNAIIHGYEGNAEGVVYISVILEEAMVKLTIRDEGIGIFNLDEARQPLFTTKPELERSGMGFTIMENFMDEVEVISNESFGTTIHLTKYLSNSNALCN
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: SYC_VIBCH
Sequence: MLKIYNSLTRQKEEFKPIVAGKVGMYVCGVTIYDLCHIGHGRTFVSFDVVARYLRYLGYDLTFVRNITDIDDKIIKRAAENAETCESLTERLIQEMYADFDALNIKRPDVEPRATAYIEEIIALVERLIERGFAYVADNGDVMFEVSQYSEYGKLSKQDLDQLQAGARVDIEAAKRSPLDFVLWKMSKPGEPTWESPWGSGRPGWHIECSAMNSSILGTHFDIHGGGSDLQFPHHENEIAQSCCAHDTQYVNTWMHSGMVMVDKEKMSKSLGNFFTIRDVLGHYDAETVRYFLMSGHYRSQLNYSEENLNQARASLERLYNALRGLDRSVPAAGGEEYVTRFTAAMNDDFNTPEAYSVLFDMAREINRLKSEDMTNASALGSLMRELADVIGILYQEPEAFFQGSAEDEDAAQIEALIKLRNDSRATKDWANADLARDKLNEMGIVLEDGPNGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_PSEPW
Sequence: MNINATLIGQSVAFLIFVLFCMKYVWPPVITALQERQKKIADGLDAANRAARDLELAQEKAGQQLREAKAQAAEIIEQSKKRAAQLVEEARDQARVEADRVKAQALAEIEQELNSAKDALRAQVGALAVGGAEKILGATIDQNAHAELVNKLAAEI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.