PharMolix/UniProtQA huggingface dataset:
Protein: MURG_SYNY3
Sequence: MTEPIRLLIAASGTGGHLFPALALAQQLPDYEIIWLGVPDRLETTLVPRQYPLQTIPVEGFQGRPSLKTIKIGWNLLRSVFTVRKLIKSKKINAVATTGGYIAAPAIVAAKLCNIPVIFHESNFIPGKVTTWLGRWCDTVAIGFRGTAKYLPNCATVWISTPVREQFRQPQSLDLPIPPNRSLIVVAGGSQGAVTVNQQVRSCVPAWVNAGAFIVHLTGKNDPEAATFSHDHYLSLEFFDNMAALLQKADLAISRAGAGTLTELAVTQTPSILIPYPFAAENHQMYNAQVFVDAGAALMFAQKSLTAEQLEQAGLDLLQSPENLATMAKAAGTLADLDSAEQLAAIVRASVEKSR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: C_MEASC
Sequence: MSKTDWNASGLSRPSPSAHWPSRKPWQHGQKYQTTQDRTEPPARKRRQAVRVSANHASQQLDQLKAVHLASAVRDLEKAMTTLKLWESPQEISRHQALGYSVIMFMITAVKRLRESKMLTLSWFNQALMVIAPSQEETMNLKTAMWILANLIPRDMLSLTGDLLPSLWGSGLLMLKLQKEGRSTSS
What are the official names of this protein?
Protein C.
What is the protein family that this protein belongs to?
Belongs to the morbillivirus protein C family.
Protein: PSAA_TETOB
Sequence: MTISSPEREAKKVKIAVDRNPVETSFEKWAKPGHFSRTLSKGPNTTTWIWNLHADAHDFDSHTSDLEEISRKVFSAHFGQLGVIFIWLSGMYFHGARFSNYEAWLSDPVHIKPSAQVVWPVVGQEILNGDVGGGFQGIQITSGFFQLWRASGITSELQLYTTAIGGLVMAAAMFFAGWFHYHKAAPKLEWFQNVESMLNHHLAGLLGLGSLSWAGHQIHVSLPVNKLLDAGVDPKEIPLPHEFLLNRQIMQDLYPSFAKGLAPFFTLQWGEYSDFLTFNGGLNPVTGGLWLSDTAHHHLAIAVLFLVAGHMYRTNWGIGHSMREILDAHKGPFTGEGHVGLYEILTTSWHAQLAINLALFGSLSIIVAHHMYSMPPYPYLATDYGTQLSLFTHHNWIGGFCIVGAGAHAAIFMVRDYDPTNNYNNLLDRVIRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPVFAQWIQKTHFLAPQLTAPTALSATSATWGGDVVAVGGKVAMMPISLGTSDFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNSLSIAIFHFSWKMQSDVWGTVTANGVSHITGGNFAQSANTINGWLRDFLWAQSSQVIQSYGSALSAYGLMFLGAHFVWAFSLMFLFSGRGYWQELIESIIWAHSKLKVAPSIQPRALSITQGRAVGVAHYLLGGIATTWSFFLARIIAVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: UPPP_PELUB
Sequence: MFSNIIEIIILSIVQGISEFLPISSSAHLNIVEIIFEFNSNSLMIDVSLHLGSLLAIVFYFRRELLDLRNNQKLLSLLIIGSIPIVIAGYVISSTGLVNLLENNLKIIAWTTLIFGIILYLADKSKFDKKISSNLNFKTILYIGLFQILALIPGVSRAGITITAARLFRFNRFDSSKISFLLAIPAIAGASVLQLKNAIGQSFELNYLVLISITLSFLFSYFTVKFFLDYINKFSLNVFVIYRIIISIILFIIIYN
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNMA_CHLPN
Sequence: MQQTVIVAMSGGVDSSVVAYLFKKFTNYKVIGLFMKNWEEDSEGGLCSSTKDYEDVERVCLQLDIPYYTVSFAKEYRERVFARFLKEYSLGYTPNPDILCNREIKFDLLQKKVQELGGDYLATGHYCRLNTELQETQLLRGCDPQKDQSYFLSGTPKSALHNVLFPLGEMNKTEVRAIAAQAALPTAEKKDSTGICFIGKRPFKEFLEKFLPNKTGNVIDWDTKEIVGQHQGAHYYTIGQRRGLDLGGSEKPCYVVGKNIEENSIYIVRGEDHPQLYLRELTARELNWFTPPKSGCHCSAKVRYRSPDEACTIDYSSGDEVKVRFSQPVKAVTPGQTIAFYQGDTCLGSGVIDVPMIPSEG
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_THEP1
Sequence: MRVKYFGTDGIRGVFGETLTDELAFKVGKALGEIVGEGRVIVGKDTRVSGDSLEAAISAGLTSMGVDVLLCGVLPTPAVALLTRITRSFGVVISASHNPPEYNGIKVLKGGYKIPDEMEVKIEEKIESGYFPVRSVVGRTKSFREGRDMYIGAVLEIFRDLDLTGEMVSLDLANGATTTTAKEVFEFLGAKVEVFNDSQDGLLINQGCGATHPRFLAEEMKNGKVGFTFDGDGDRVIAVDEERNVVNGDRIIGILAVGLKEEGRLNSDTVVGTVMTNGGLEDFLKERGIKLLRTKVGDKYVLEKMIESGANLGGERSGHIIILDRSTTGDGLITALELMRVLRRSGRNLSDFAKEIPDYPQITKNVRRTERMSLENENLRKIVEESTSRGYRVVIRPSGTEPVVRITVEGKDREEIEKIVEEISRVLES
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: CTPD_MYCTU
Sequence: MTLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVALLLFLAGLVAQLNGAPEAMWWTLYLACYLAGGWGSAWAGAQALRNKALDVDLLMIAAAVGAVAIGQIFDGALLIVIFATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSERVVAASELVVGDRVVVRPGDRIPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGTVNGSGVLHLVVTRDPSQTVVARIVELVADASATKAKTQLFIEKIEQRYSLGMVAATLALIVIPLMFGADLRPVLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVVERLADTSIVALDKTGTLTRGIPRLASVAPLDPNVVDARRLLQLAAAAEQSSEHPLGRAIVAEARRRGIAIPPAKDFRAVPGCGVHALVGNDFVEIASPQSYRGAPLAELAPLLSAGATAAIVLLDGVAIGVLGLTDQLRPDAVESVAAMAALTAAPPVLLTGDNGRAAWRVARNAGITDVRAALLPEQKVEVVRNLQAGGHQVLLVGDGVNDAPAMAAARAAVAMGAGADLTLQTADGVTIRDELHTIPTIIGLARQARRVVTVNLAIAATFIAVLVLWDLFGQLPLPLGVVGHEGSTVLVALNGMRLLTNRSWRAAASAAR
What is the function of this protein?
Involved in heavy metal homeostasis.  Probably exports nickel and cobalt ions out of the cell (By similarity).
What are the official names of this protein?
Probable cobalt/nickel-exporting P-type ATPase, Cation-transporting P-type ATPase CtpD.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLM_SHIF8
Sequence: MGKTQPLPILITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLINAGAQCIQADFSTNDGVMAFADEVLKTTHGLRAILHNASAWIAEKPGAPLADVLACMMQIHVNTPYLLNHALERLLRGHGHAASDIIHFTDYVVERGSDKHVAYAASKAALDNMTRSFARKLAPEVKVNSIAPSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIDLVDYLLTSCFVTGRSFPLDGGRHLR
What is the function of this protein?
Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin.  Also has lower activity with dihydrofolate.
What are the official names of this protein?
Dihydromonapterin reductase, H(2)-MPt reductase, Dihydrofolate reductase, DHFR.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily.
Protein: ATG4_MAGO7
Sequence: MDSAVAGAADIGRYGRRIVRMIWDPEPTNDPIANRPAWCLGYEYTLETNITSKTKGEDSKLSTATSSDQQRPPAQANKVPQMPSAQLPTEAAATALSGNTTPPTPEAALEPTKITSQPAAIDTPPDSVDSSFDSSMAYDDVPDDGGWPPAFLNDFESRIWMTYRSGFEPIPRSTDPTASSRMSFAMRLKTMADQQAGFTTDSGWGCMIRTGQSLLANSLLTCRLGRSWRRGQAPDEERKLLSLFADDPRAPYSIHNFVAHGAAKCGKYPGEWFGPSATARCIHALANATENSFRVYSTGDLPDVYEDSFMEVAKPDGKTFHPTLILISTRLGIDKINQVYWESLTATLQLPQSVGIAGGRPSSSHYFVGAQRSDEDQGSYLFYLDPHHTRPALPFHEDPQLYTPSDVDSCHTRRLRRLHIREMDPSMLIGFLILDEENWHAWKSSVKHVQGKSIITVSEHDPSKGSASGRPSAIDEVETLSDDDGDTVLDG
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8 (PubMed:19923912).  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS (By similarity).
What are the official names of this protein?
Cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: SYK_PROMP
Sequence: MSEIREARLLKANSLVKKGFEPYAETFKITHSTKFLTEKFGYLENGQDFNLDVAIAGRVLAKRVMGKIAFYTIADQEGKIQLYLEKKILDDFEIHAKLLSFEDLKEIVDIGDWIGVYGTIKKTNKGELSIKVSKWEMLSKSLQPLPDKWHGLTDIEKRYRQRYLDLIVNPLSKNVFKTRAKCISLIRRWLDEKNFLEIETPILQSEAGGAEARPFITHHNTLDIPLYLRIATELHLKRMVVGGFEKVYELGRIFRNEGISTKHNPEFTSVEIYQAFSNYIDMMNLTEDLIRDIVLSCCDSLIINYQEKVIDFSKPWKRISMKDVVMEYTGIDFDSFNGDLNKAMKDLEESNIEISPKINTLGRLLNEVFEEKVESQLVEPTFVIDYPIEISPLARPHPENKEMVQRFELFIAGRELANAFSELIDPVDQRKRMQLQQSLRDAGDLEAHCIDEDFLQALEIGMPPTGGLGIGIDRLIMLLTNSPSIRDVITFPLLKPEITSTKSEKSTSNEVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAP_MYCTU
Sequence: MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ
What is the function of this protein?
Efflux pump that contributes to intrinsic antibiotic resistance (PubMed:9811639, PubMed:12520088, PubMed:20525733, PubMed:30837962).  The pump uses the electrochemical gradient as a source of energy (By similarity).  Confers resistance to rifampicin (PubMed:20525733).  Confers low-level resistance to tetracycline and to several aminoglycosides, including streptomycin, gentamicin, 2'-N-ethylnetilmicin and 6'-N-ethylnetilmicin (PubMed:9811639, PubMed:12520088).
What are the official names of this protein?
Multidrug efflux pump Tap, Tetracycline/aminoglycoside resistance-like efflux pump.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Drug:H(+) antiporter-3 (DHA3) (TC 2.A.1.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECR_RUMCH
Sequence: MEYYAVPIAKLVEEFQKLPGIGHKSAQRLAFHVINLPMEKVQKLSESILEAKQKTRYCSVCSNLTDIDPCPLCSGTSRDKTVICVVQDPRDVVAMERTREFKGLYHVLHGAISPMQGIGPEEIRIKELITRLGSGDVKEVILATNPNVEGEATAMYISKLIKPLGVKATRIAHGIPVGGDLEYADEVTLAKALEGRREI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: CYC_TETNG
Sequence: MGDIAKGKKTFVQKCAQCHTVEEGGKHKTGPNLWGLFGRKTGQAEGFSYTDANKSKGIIWNEDTLLEYLENPKKYIPGTKMIFAGIKKKAERQDLIAYLKSSTS
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: SYQ_VIBA3
Sequence: MSEAEARPSNFIRQIIDKDLADGTHSSVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYQGQCNLRFDDTNPEKEDVEYVESIKNDVSWLGFEWSGDICYSSNYFDTLYAYAVELINKGLAYVDELSPDQIREYRGTLKEPGKASPYRDRSPEENLALFEKMRDGGFEEGKACLRAKIDMSSSFMVMRDPVIYRVRFAHHHQTADKWCIYPMYDFTHCISDALEGITHSICTLEFQDNRRLYDWVLDNITIDCQPRQYEFSRLNLEYTVMSKRKLNQLVVENLVEGWDDPRMPTISGLRRRGFTSSSIREFCKRIGVTKQENMIEFGSLESCIRDDLNENAPRAMAVLDPIKVVIENYDADTVETLTVANHPNKPEMGTREVPFTREVWIERDDFREEANKKYKRLVLGKEVRLRGAYVIKAERIEKDAEGNITTIFCSYDNETLGKNPADGRKVKGVIHWVSADKALPAEIRLYDRLFTVPNPAAADDFAATLNPESLVTLNGFVEPSLAEGVAEQAYQFERTGYFCVDSKDSKADALVFNRTVGLRDTWGKTEA
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_XANCP
Sequence: MDVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEELDEVPDDATVIFSAHGVSQAVRVEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIGHAGHPEVEGTMGQWSRERGPGQIYLVEDIEQVATLQVRQPESLAYTTQTTLSVDDTMGIIEALRVRYPAMQGPKHDDICYATQNRQDAVRDLARQCDLVLVVGSPNSSNSNRLSELARRDGVESYLIDNASEIDPAWIVGKQHIGLTAGASAPQVLVDGVLARLRELGANGVSELAGEPESMVFALPKELRLRLVS
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: EX7L_RICB8
Sequence: MLDNFTSSQTTKEFSVSEISNKIKELLENNFGYIKVKGEISGLKIASSGHAYFNLKENTAILACTCWRPILAKIKFPLNDGMEVVISGKLSSYAGNSRYQLSVENLQPAGLGAMVQILNERKARLEKEGLFNKIRKPIPFLPNKIGVITSITGAVIQDIIHRIRERFPTHVIIWPVSVQGENSGNEIAEAIDGFNKLEEANKPDVIIVARGGGSIEDLWSFNDEVLVRATYNSKIPIISAVGHEVDYTLIDLAADKRAPTPTAAAEFAVPVRSILNSTLQSYEKVLVTNTKQLVKNHEQAITNYDKINRYLAHYINHKQQLLDETGFNLLDSLPCLISLKETKLKSFSKERIHPHKIITYKTLELTHKAAYIIKSANNTLKNFEYKLELNSLLLLSLDYHNVLKRGFAIVKGESGNFVSSKTTTEKVLNIQFFDGNIKAVRD
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCT2A_XENLA
Sequence: MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKKVGTRSLDFSDRITKSKRTGYESGEYEILGEGIGMKETPQQKYQRLLHEVQELTQEVEKTQSTVKESAAEEKLTPVALAKQVASLKQQLVSTHLEKLLGPDAAINLTDPDGALAKRLLTQLDAAKTRKNPEGKSPAKGPGPDTENLVTYELHCRPEQNKFSQAAKMAELEKRLGELEVAVRCDQDTQNPLTVGLQGSCLMDTVEILQAKVNLLDVASLDQVEARLQSVLGKMNEIAKHKAAIEDADTESKVHQLYETVQKWDSMSGTLPQVVQRLLTLKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTNALAMVQKAMKENLATVEDNFSNIDGRIKKLSK
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.  In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity).  Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.  Involved in anchoring microtubules to centrosomes (By similarity).
What are the official names of this protein?
Dynactin subunit 2-A.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunit 2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
Protein: DER_GEOSM
Sequence: MKPIIAIVGRPNVGKSTLFNRLVGRRKAMVDDMPGVTRDRNYAEVNRFDVPFILVDTGGFEPETSDRLLQQMREQSRFAMDEADLILFVMDARGGLTPADRDVVDMLRRINKPVFYIINKVDGEKQEAEAGDFYSLGVDHIHTISAEHNRGVGDLMDEVLAAIPYDREKESDEEITRIAVVGRPNVGKSTLVNRLLGYERVVANPTAGTTRDAVDTRFTVNKKPYLLIDTAGIRRKGKTVQKVEKYSVMDALRSIERADVVLIVLNAEEGVTEQDSKIAGYAYEAGRGCIFVVNKWDTLAKDNSSIAKFTEEIRRNFKYLPFAPILFVSAETGQRTGKIIAEVDQVMEQYCKRVTTGELNRVFTQAVDENHAPLSAGRRVKFYFATQVAVKPPSFVVFTNCPEGIHFSYERYIMNRFREAFGFNGTPLKLIFRGRDKKDA
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PROA_CHLAA
Sequence: MVDLEAIGRRAKTAARALAKLSTEQKNAALCAIADGLLARQDKILAANAADVADAEKGGTPPAIVDRMLLTPARLAAIAGDCRQVASLPDPVGEIFDRRELPSGLRLYKRRVPIGVIGAIYEARPNVTVDIASLCLKAGNAVILRGGSDIARSVAATTEVIALALEQAGLPAFAVQSIIDPDRELVRQLLRLDRYVDMIIPRGGAGLHRFCVENATVPVIVGGMGVSHIYVEPSADFARAVPVIVNAKVQRPGACNALDTLLVHRAAASTFLPLVAAALAQHGVELRCDLEALAILADAPGHEAWNLKPASPTDFGCEFLALIVAIKIVGSIDEALDHIALYGGHSEAILTGDPISAERFTREVDATAVFVNASTRFNDGGQFGLGAEVAISTNRLHARGPMGLQELTTYTWIGEGDYLVRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF12_POLAQ
Sequence: MAKEELLEMEGLVDEILPDSRYRITLDNGHKLIAYTAGRVKKNHIRILAGDKVSLEVSPYDLSKGRITFRHIDKKQSFAGAPYRRH
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 2.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_BORPD
Sequence: MEFEHRPVLLAPTVDALLLADFAGKGAARSGRQDGAQADARAQRGVFVDGTFGRGGHSRELLRRLGPEARLVVFDKDPQAIAVANELAAGDARVTVVHGGFAAMREELAARGIESIDGVMLDLGVSSPQLDDAGRGFSFMREGPLDMRMDTTRGPTVADWLAQASVDEMREVIADYGEERFAFQVAKAIAARRATRPLRTTLELAECVASAVRTREKGQHPATRTFQALRIYINRELEELSRALASALELLAPGGRLAVISFHSLEDRMVKQCIAAAARPAVAHARLPLRESELPQPLYRSLGRVQADDEEIAGNARARSAVLRVAERTTEPLGADGAAAFVPAMRVPGEAAPARRGARRRPH
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H33_DROHY
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin.  Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.3, H3.A/B.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NU4LM_SHEEP
Sequence: MSLVYMNIMMAFTVSLTGLLMYRSHLMSSLLCLEGMMLSLFILATLMILNSHFTLASMMPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DI3L1_DANRE
Sequence: MIKTEKILHLNSSKGRKVRVVREHYMREQVPCGSSLCQADCQNVGKVLSRDVTHYVVPDVGVVRDFLEILELRELQGIVLTQTAYQTVQHTRGRRHYNRLRSLLKDPRHDCVLFANEFQQYSYCPREKGESQDKWHTRNVYNAAVWYYNHLAGLQPVVMITEDRDAISEFSASNSGVFVISTQEYLLGFWPDLQAAHDLYHSIAQTLQERENDGAEKVYTEHLPAEVLEAGIKSGRYIQGILSVNKHRAQHEAFVRYEGSASKNTELNSDVLINGAKHRNRAVHGDVVVIELLPRNEWKGRTMALTEGQGEERPLEDTQSQPMPTGRVVEILQRNWRDYVVTLPPFEEMQSQSRNSQKILVVPWDYRIPKIRISTQQAEALQDQRVIVRLDSWESTSVYPNGHFVRVLGKSGELETEIQTILVENCIHVPPFSEAQLREMPVNTEENPWQMDSNEVSSRRDLRDSHLVFSIDPKGCEDVDDTLSVRTLPGGKRLELGVHIADVTHFVREGSLTDLEARSRATTYYLADRRYDMLPAVLSADLCSLLGGVDRYAMSVLWELDAETLEVCSVWFGRTLIRSSYQLHYELAQSLLNGEEVEVPELNPLKGSQRDQKMSELLQALETLTRVARHLRAQRDKGGALELEGVEVRAQLDEEKNITALVPKQPLEVHETVAECMIYANHWVARKIQESFPHHALLRHHPPPKQEFFNHLIDSAKAHGFSIDTRSNRALADSLERAVDPRDPLVNRLLRMMATQAMSNALYFSTGSCPEEQYYHYGLALARYTHFTSPIRRYADVIVHRLLMAAVQLEKDESPSKALACNKELEELAQHINNKNRAAQHSQKQSIELFQCMYFRDKDSHTDERCVADAVIYAVRANGFLAFVPQYGLKGAVYLKDREGQVISVDGDGKCEWKPGTLQKYSDKIITSTSTGTHTFYLFNHVTVRISVEPSRCHADSLNLELISNKPHCAVQPESQPAGGGRSGLVEEVVRWAEEASLQAEEQRGRKPKLSKEEKQFRQSKTPNLYVLLQEISELALMDLSICQITNSEEQTCTVSS
What is the function of this protein?
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.
What are the official names of this protein?
DIS3-like exonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.