PharMolix/UniProtQA huggingface dataset:
Protein: MDM12_CANDC
Sequence: MSFDINWNQLTIDDTINQSIKEFLDQQFKKISLPSFISNLSVTDFNLGEIPPEITIRHIGDPFEEFYEDEDNLGATNETNHNLNDERSTMGKSQENGIHKDNAYNSQNFDDDDDDDEGVDEDDDDDEYDDHDLGTINEGISLLNFNDSSTTPSGNSFGGSIAPLPPPPLNPSRDSFHSILHPYGVNSIIGATGAGSETPTNILNQNYLSSRVLPKISVKQKQPHHDDNDIQLIVEINYKGDMHINLLVNLLVNYPSPNFISLPIKLHITDIVIHSIATIAYLKKSVYLSFLCDVDDAFPDFDSNNNAQTPTSTTGGNFVDYYSNDAAINKERIDIVKKIKIESEIGEVENNILRNVGKVEKFLVEQLRNILRDEIAWPSWICIDMNDDGDDDDDDEVEDSNVSDGDGKDNDGKHGDGPTHEV
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: DFB12_MOUSE
Sequence: MALSREVFYFGFALFFIVVELPSGSWAGLEYSQSFPGGEIAVCETCRLGRGKCRRTCIESEKIAGWCKLNFFCCRERI
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 12, BD-12, mBD-12, Defensin, beta 12.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: XYLG_PSEPU
Sequence: MKEIKHFISGELVGSASGKLFDNVSPANGQVIGRVHEAGRAEVDAAVRAARAALKGPWGKMTVAERAEILHRVADGITARFGEFLEARMPGHRQAEVAGQPHRHSARRANFKVFADLLKNVANEAFEMATPDGAGALNYGVRRPKGVIGVISPWNLPLLLMTWKVGPALACGNCVVVKPSEETPLTATLLGEVMQAAGVPAGVYNVVHGFGGDSAGAFLTEHPDVDAYTFTGETGTGETIMRAAAKGVRQVSLELGGKNAGIVFADCDMDKAIEGTLRSAFANCGQVCLGTERVYVERPIFDAFVARLKAGAEALKIGEPNDPEANFGPLISHKPREKVPSYYQQAVDDGATVVTGGGVPEMPAHLAGGAWVQPTIWTGLADDSAVVTEEIFGPCCHIRPFDSEEEAIELANSLPYGLASAIWTENVRRAHRVAGQIEAGIVWVNSWFLRDLRTAFGGSKQSGIGREGGVHSLEFYTELKNICVKL
What is the function of this protein?
2-hydroxymuconic acid semialdehyde can be converted to 2-hydroxypent-2,4-dienoate either directly by the action of 2-hydroxymuconic semialdehyde hydrolase (HMSH) or by the action of three sequential enzymes, the first of which is HMSD.  Can oxidize not only 2-hydroxymuconic semialdehyde and its analogs but also benzaldehyde and its analogs.
What are the official names of this protein?
2-hydroxymuconic semialdehyde dehydrogenase, HMSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: TVA12_HUMAN
Sequence: MWGVFLLYVSMKMGGTTGQNIDQPTEMTATEGAIVQINCTYQTSGFNGLFWYQQHAGEAPTFLSYNVLDGLEEKGRFSSFLSRSKGYSYLLLKELQMKDSASYLCA
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 1-2.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RECR_PHYMT
Sequence: MKNSPTVEKLIESFTLLPGVGKKTAERYTFFLINQKNKNKILYLSKHLKELVNNIKSCNICGYITEKNICNFCSDSQRDHSTIMIVADNRDVYCFEKINHYHGLYHILGGLIDFSRCIKPENLNFNSLKDRLKTIKEIIIATNSTLEGEITATYSKKFLKKYLKDEKIKITKLAYGIPIGLDFNYLDEKTLCNAINNRNNFKGENE
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: PSBK_SECCE
Sequence: MPNILSLTCICFNSVLYPTSFFFAKLPEAYAIFNPIVDIMPVIPLFFFLLAFVWQAAVSFR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: COQ7_LEGPH
Sequence: MRTSSFLDRLIGEVDSALRTLVLPQKRITTRQSPAENLADTVLSAQEKKHISGLMRVNHAGEVCAQALYQGQALTARLTHIKEQMASAAAEEVDHLAWCEERLYELGSKPSLLNPIWYCGSVLLGALAGLAGDKVSLGFVAETERQVTAHLQRHLHYLPEKDKKTIAILKRMQEDEEHHAHTAMEAGAVELPYIIKQLMNAVSKLMTQSSYYI
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MURC_BARBK
Sequence: MKIPLNIGLIHFVGIGGIGMSGIAEVLHNLGYKIQGSDQANNTNIERLRSKGINVHIGHQAKNLGEAEVVVISTAIKKTNPEYIAAKEKHLPVVKRAEMLAELMRFRQAIAIGGTHGKTTTTSMVAALLDAGNFDPMVINGGIINAYGTNARMGNGNWMVVEADESDGTFLKLPADIVVVTNIDSEHLDHYGSFDAVRESFRQFVENVPFYGFAVMCLDHPEVQTLASRIDDRWVITYGANPQADVRFLNFSMKNKKAHFDVLIRSRKTGIQTELRDLVLPMSGKHNVSNATAAIAIAHELGISDEVIRKGLAEFGGVKRRFTQTGSWRGIDVFDDYGHHPVEIKAVLRAARESTNGQVIAIAQPHRYSRLCNLFDDFTTCFNDADTIMIAPVYAAGEEPITGFGSKELVEHIQMASHCDVRLIDDLEDVVSIVSTVAKSGDYVVFLGAGSITQWAYALPKRLAELDNNDEFSAN
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCKNB_XENLA
Sequence: MCSGVCICLLLAMLSASSKAHQATGSLGEDAVGTEMDQLNLSQLPRYARASSAGQKKSFQRTDGDQRSNIGNALVKYLQQSRKAGPSGRYVVLPNRPIFDQSHRINDRDYMGWMDFGRRSAEEYEYSS
What are the official names of this protein?
Cholecystokinin B, Cholecystokinin type 2.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RADB_METM5
Sequence: MLEELLNGNIEKKTITQIYGPPGVGKTNICILSMLKAIENGKNVVYIDTEGSLSIERIKQLSEQDSDELLKSIIIYEPSSFEEQSEALEKIFFLENIGLIVIDGIVSLYRLELCDNINENTKLNRMLGKQISNLLKVARMKNSGILITNQVKDSINGIEPAGGRLLEYWSKSIIKLEKTESIRKLTLEKHRHAKEGENLRFRIVQNGLEIINKSYQ
What is the function of this protein?
Involved in DNA repair and in homologous recombination.  May regulate the cleavage reactions of the branch-structured DNA.  Has a very weak ATPase activity that is not stimulated by DNA.  Binds DNA but does not promote DNA strands exchange.
What are the official names of this protein?
DNA repair and recombination protein RadB.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
Protein: GATA4_CANLF
Sequence: MYQSLAMAANHGPPPGAYEAGGPGAFMHGAGAASSPVYVPTPRVPSSVLGLSYLQGGGGAAASGASSGGGSGGAPSAAGPGAQQGSPGWSQAGADGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYGGGGGAAGAGLAGREQYGRAGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPAARHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPSGGESLPPASSASSNSSNVATSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSVSAMSGHGPSIHPVLSALKLSPQGYTSSVSQSPQASSKQDPWNSLALADSHGDIITA
What is the function of this protein?
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development.  In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression.  Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression.  Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.  Acts as a transcriptional activator of ANF in cooperation with NKX2-5.  Promotes cardiac myocyte enlargement.  Required during testicular development.  May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase.
What are the official names of this protein?
Transcription factor GATA-4, GATA-binding factor 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL18A_PYRAR
Sequence: MPRIYKIVGDTTTGMKFRIEVVAEKPYDAIEKAYSLIGSRHKLSRMQIRIREVVPISPEEARSEHVKILMAVDKIYKY
What are the official names of this protein?
50S ribosomal protein L18Ae, 50S ribosomal protein L20e, 50S ribosomal protein LX.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
Protein: MTGA_BACTN
Sequence: MHRPLPIKKILRYARNLLIFFFASTILAVIVYRFMPVYVTPLMVIRSVQQLASGDKPTWKHTWVSFDKISPHLPMAVIASEDNRFAEHNGFDFIEIEKAMKENEKRKRKRGASTISQQTAKNVFLWPQSSWVRKGFEVYFTFLIELFWSKERIMEVYLNSIEMGKGIYGAQATAKYKFNTTAAKLSSGQCALIAATLPNPIRFNSAKPSAYLLKRQKQILRLMNLVPKFPPVEKKAVDKKDTRKKKKK
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DDL_BLOPB
Sequence: MSKLCIGIICGGRSLEHEISLKSAMCIAQFIDKFRFEAMILWIDKKGCWHLKDIDFNDLSYHKDEKISILLQNCPYPFKFHTKNINILLKFDVIFPVVHGTLGEDGALQGLLCMMNLPFVGSNVLSSSVGMDKDVSKCLLRDAGLSVVPFRTVLAQDQHNIDFDYFVSIFGLPLFVKPSNQGSSIGVSKVTKCKDFNLALIKAFSFSNKILIEPAIIGRELECAVLGNDNPKISVCGEVILSDNNFYTYHDKYVKRKAQIMIPALINDAISDDIRHIALRAFQVLNCSGMARVDVFLNLDNKIFINEVNTLPGFTFDSMYPKLWEVSGLNLQELITKLVELALDLHDKKNCFYHVDGAVLKYFRHERI
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_OLEA2
Sequence: MIVITTRTGAMTGFPLSRHDIRIALHSMLSCLGLSGAHVEVILTDDGESAQLNREFLGCYGPTNILSFPAAGPVAAPRQEPDSPPACRKDSSHAEDDTDLGVLALSTGAVHRESFLYGQPPHRHALRLLAHGLLHLAGYDHGPQMDDMTETLMQCATGKAAADTVVTGF
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_CAMJ8
Sequence: MKIKVGILGASGYAGNELVRILLNHPKVEISYLGSSSSVGQNYQDLYPNTPLNLCFENKNLDELELDLLFLATPHEFSAKLLNENLLKKMKIIDLSADFRLKNPKDYELWYKFTHPNQELLQNAVYGLCELYKEEIKKASLVANPGCYTTCSILSLYPLFKEKIIDFNSVIIDAKSGVSGAGRSAKVENLFCEVNENIKAYGLASHRHTPEIEEHLSYAAKEKITLQFTPHLVPMQRGILISAYANLKEDLQEQDIRDIYTKYYQNNKFIRLLPPQSLPQTRWVKSSNFADINFSVDQRTKRVIVLGAIDNLIKGAAGQAVQNMNLMFDFDEDEGLKFFANL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_VEREI
Sequence: MLDNPKLTARQQQVLDLIQNTMARTGAPPTRAEIAAELGFKSANAAEEHLQALARKGAIELVSGTSRGIRLHSETLRSIHAARSGPSGAGNPGSSPWVLPLIGRVAAGSPILAQEHVEQTYSVENGLFQHKPDYLLKVRGMSMRDAGIIDGDLLAVQATREARNGQIIVARLGDDVTVKRLRRTASTIELLPENPDYPVIVVQPGEPFEIEGLAVGLIRNTMLM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: YJJB_SALCH
Sequence: MGIIDFLLALMQDMILSAIPAVGFAMVFNVPHRALPWCALLGALGHGSRMLMMSAGFNIEWSTFMASLLVGSIGIQWSRWYLAHPKVFTVAAVIPMFPGISAYTAMISAVKISHLGYSEPMMITLLTNFLKASSIVGALSIGLSVPGLWLYRKRPRV
What is the function of this protein?
Involved in succinate export with YjjP.  Both proteins are required for export.
What are the official names of this protein?
Probable succinate transporter subunit YjjB.
What is the protein family that this protein belongs to?
Belongs to the ThrE exporter (TC 2.A.79) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ZAPA_SALG2
Sequence: MSAQPVDIQIFGRSLRVNCPPDQRDALNQAADDLNQRLQDLKVRTRVTNTEQLVFIAALNISYELTQEKAKTRDYAASMEQRIRMLQQTIEQALLDQGRITEKTGQNFE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell.
Protein: RS20_DICT6
Sequence: MANTKSAIKRIKISERNRIRNRIRLGKIKFYTKQFLKLLEENKIEEAKKVLPEVISAIDKAAQKGTLHKNTAARKKSKLMRLLNQKLSANLSS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: Y1180_BURO1
Sequence: MQVLVDADACPAVIKDMLFRAARRAEICVTLVANQFLRTPPSPFIKAVQVPAGFDVADARIVELAEPGDLVITADIPLAAAVLDKGAHALDPRGNWFSRENIEERLSTRAMMDQLRSAGIDTGGPAPFSARDGKTFASQLDRFLARHAPR
What are the official names of this protein?
UPF0178 protein Bcen_1180.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: PAHO_MOUSE
Sequence: MAVAYCCLSLFLVSTWVALLLQPLQGTWGAPLEPMYPGDYATPEQMAQYETQLRRYINTLTRPRYGKRAEEENTGGLPGVQLSPCTSPPVGLIPCSAPWS
What is the function of this protein?
Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2.
What are the official names of this protein?
Pancreatic polypeptide prohormone.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: SEN34_ASHGO
Sequence: MPHTKVAISLNSKTGVPLVFDLDDVRRIRGLGVLGTLCGSLPTAAQQNLFLTVPLRLMLEDAVWLVLSGHAYFSFDDKLLVQAAGSLTAAEVCRWRQDTERGLEQQRELRRREQQLKLAALHRTADETDTQRRLLEQSLFLETENCSKMIAAAEPAGLQLAILREMVAQHLDLGNYLIYRYLREEQYFLSAGGRFGARYVAYPGDPLRYHSHMAVQPAMDYYNESLDLLHVVGGGRLGTGVKKLWVVGGVRYREAEAAATAEEQIPPPDTLDRLLATSPPVSVFSIEWSGFG
What is the function of this protein?
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA.  It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini.  There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.  It probably carries the active site for 3'-splice site cleavage (By similarity).
What are the official names of this protein?
tRNA-splicing endonuclease subunit SEN34, tRNA-intron endonuclease SEN34.
What is the protein family that this protein belongs to?
Belongs to the tRNA-intron endonuclease family.
Protein: COBT_BRUA4
Sequence: MSASGLPFDDFRELIRNLPGPDLGAERAVREREATLTKPAGSLGRMEDIVAWLAAWTGKRTPQINRPLVAVFAGNHGVTAKNITPFPPSVTAQMVENFAAGGAAINQICIANDLGLKVFDLALEHPTGDITEEPAMDERTCAATMAFGMEAIAGGTDLLCIGEMGIGNTTIAAAIALALFGGTAEDWVGPGTGSTGELLQRKLAAVRQAVALHQAHLQDPLEVLSRLGGREIAAMAGAILAARMEKIPVIVDGFVASAAAAVLYAANPEAIDHCLFGHVSAEPGHRKLLEKMGKQPLLDMGMRLGEGTGAALAASIVKAAALCHSGMATFEQAGISGSK
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: TLR2_MACFA
Sequence: MPHTLWMVWVLGVIISLSKEESSNQASLSCDHNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRYVNLQALVLTSNGINTIEEDSFSSLGRLEHLDLSYNYLSNLSSSWFKPLSSLKFLNLLGNPYKTLGETSLFSHLTKLRILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDLTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLSQISGLLELEFDDCTLNGVGDFRGSDNDRVIDPGKVETVTIRRLHIPQFYSFNDLSTLYPLTERVKRITVENSKVFLVPCLLSRHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLGKTGETLLTLKNLTNLDISKNTFHYMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDISNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNTITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLVDWPANYLCDSPSHVRGQRVQDVRLSVSECHRAALVSGMCCALFLLILLMGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPNRDICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILVLLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEARQEGFWVNLRAAIKS
What is the function of this protein?
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components.  Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  May also promote apoptosis in response to lipoproteins.  Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway.  Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
What are the official names of this protein?
Toll-like receptor 2.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.
Protein: SYI_CORDI
Sequence: MSDAVGGVYPRVDMSGGTNVFPDMERQVLEYWKDDETFKASLTNREENPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYQTMKGKLVNRVFGWDCHGLPAELEAEKQLGIKDKGEIEAMGLESFNNYCAKSVLEYTQEWKDYVTRQARWVDFDNGYKTMDMDFMESVMWAFKTLYDKGLIYQGFRVLPYSWAEHTPLSNQETRLDDSYKMRQDPTLTVTFPITGVKDDSAADASLVGAYALAWTTTPWTLPSNLALAVNPQVNYVEVKVGDQGAEAIRGQRVLLAEALVGAYAKELGEDHEVLTVRPGSELVGLTYQPIFSYFADHENAFQILAAEYVTTEDGTGIVHQAPAFGEDDMNTCKEYGIEVVIPVDMDGKFTSLVPEYQGQLVFDANKSIIADLKAAGRVVRHQTIEHSYPHSWRSGEPLIYMALPSWFVEVTKIRDRMVELNKEIDWMPSHIRDGQFGKWLEGARDWNISRNRYWGSPIPVWVSDDENYPRVDVYGSLEELERDFGVRPESLHRPHIDELTRPNPDDPTGKSTMRRVPEVLDCWFESGSMPFAQKHYPFENKDWFDTHSPADFIVEYSGQTRGWFYTLHVLATALFDRPAFKKVVAHGIVLGDDGTKMSKSRRNYPDVNEVFNRDGSDAMRWFLMSSPILRGGNLIVTEQGIREGVRQALLPMWNAYSFLQLYSSKPAQWSVDSSDVLDRYILAKLHDVVAAVGDALDNTDIARACDEVRTFCDALTNWYVRRSRDRFWAGDTEHPEAFYTLYTVLETLTRVTAPLLPMVSEVIWRGLTGERSVHLADFPQADQFPADDDLVRAMDEVRGVCSATSSVRKAHKLRNRLPLPKVTVALPESARLADFADIIRDEVNVKEVALTSDVDSVGRFDVVVNAKVAGPRLCKDVQRAIKAVKSGNYERRGDTVVADGIELVAGEFTERLVAADPDSTTQIDGVDGLVVLDMTLTEELEAEGWAADVIRGLQDARKASGFEVSDRIEVKLVVPEEKKEWALRHTDMIAGEVLATSFEVVTGEPAEHDIVAGVTATVQKV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.