PharMolix/UniProtQA huggingface dataset:
Protein: SYGA_LEUCK
Sequence: MTSQKLSLQDIILTLQQYWANQGANLMQAYDNEVGAGTQSPYTFLRANGPEPWHAAYVQPSRRPADGRYGDNPNRLFQHHQFQVVMKPSPDNIQELYLGSLEALGIKPLEHDIRFVEDNWENPSMGAAGIGWEVWLDGMEVTQFTYFQQVGGIEVDSVTAEVTYGLERLASYIQDVPTVYDLDWGNGVLYGDIFKEPEYEHSKYAFEASDQAMLLRHFDDFEKEATRLLDLGLVHPAYDYILKSSHTFNLLDASGSVSVTERAGYLHRIRTMARRVSKVFIDERAKLGFPLLKDDDLREIYLGEHGKYTLTEEN
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA_BACCZ
Sequence: MTTIDLNCDLGESFGAYKMGNDDEILPFVSSINVACGFHAGDPSVMRQTVEKAMQHNVAIGAHPGFPDLIGFGRRNMNVSASEVYDYVLYQIGALDTFVKAAGGKMHHVKPHGALYNMAATNPEIADAIAKAIYHSNPSLLFYGLANSEAFIQAAEKYNITLVQEAFADRTYKQDGTLTSRTEENALIKNEEEAIKQVLQMVKEGYVNSVNGEKVAVQAQTICLHGDGEKAVQFARRIYRTFENNEISICTPK
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: OGR1_MOUSE
Sequence: MGNITTENSSLSCPIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTIADLFYICSLPFWLQYVLQHDDWSHGDLSCQVCGILLYENIYISVGFLCCISIDRYLAVAHPFRFHQFRTLKAAVGVSVLIWAKELLTSIYFLNHKEVIEDEDQHRVCFEHYPIQAWQRSINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSLWERNCEFAKSIFNVYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAVLTCSRTSRAREAYPLGAPEASGKSGAQGEEPELLTKLHSAFQTPSSLGVGGPSTVGLA
What is the function of this protein?
Proton-sensing receptor involved in pH homeostasis.  May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone.  Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization.  The receptor is almost silent at pH 7. 8 but fully activated at pH 6. 8.  Also functions as a metastasis suppressor gene in prostate cancer.
What are the official names of this protein?
Ovarian cancer G-protein coupled receptor 1, G-protein coupled receptor 68, Sphingosylphosphorylcholine receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MATPI_SCHKA
Sequence: MKRVAVLLKTVMCEFLKCDYNGYDRIISLLRRILTLICTPNLNGLTIKRVIDSMQSLEYIKQTCNFKLQMCISSMAFKRNNALQNCNHYAWCDDHCSDIGRPMTTVRGQCSKCTKPHLMRWLLLHYDNPYPSNSEFYDLSAATGLTRTQLRNWFSNRRR
What is the function of this protein?
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion.  Required for meiosis, but plays no role in conjugation (By similarity).
What are the official names of this protein?
Mating-type P-specific polypeptide Pi.
What is the protein family that this protein belongs to?
Belongs to the TALE/M-ATYP homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GK_HHV1K
Sequence: MLAVRSLQHLSTVVLITAYGLVLVWYTVFGASPLHRCIYAVRPTGTNNDTALVWMKMNQTLLFLGAPTHPPNGGWRNHAHISYANLIAGRVVPFQVPPDATNRRIMNVHEAVNCLETLWYTRVRLVVVGWFLYLAFVALHQRRCMFGVVSPAHKMVAPATYLLNYAGRIVSSVFLQYPYTKITRLLCELSVQRQNLVQLFETDPVTFLYHRPAIGVIVGCELIVRFVAVGLIVGTAFISRGACAITYPLFLTITTWCFVSTIGLTELYCILRRGPAPKNADKAAAPGRSKGLSGVCGRCCSIILSGIAMRLCYIAVVAGVVLVALHYEQEIQRRLFDV
What is the function of this protein?
Glycoprotein that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes.  Also plays a role, together with gB, in virus-induced cell-to-cell fusion (syncytia formation).  Seems to block fusion of virions with infected-cell membranes (By similarity).
What are the official names of this protein?
Envelope glycoprotein K, Syncytial protein.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein K family.
What are the subcellular locations of this protein?
Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with UL20 to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Cell surface expression of gK is required for virus-induced cell-to-cell fusion. Probably not present in extracellular virions (By similarity).
Protein: CHLE_ASPNG
Sequence: MLLRLCIIATLLVSHCVAVSTSPATRDTNGEGLLVQTSSGPIQGFFNQTAPDVRQWLGVPFAEPPVGDLRFSSPVKKQPNGTVNAFALPSSCIQQTSNSSTIYTTYETGFLISGGDSEDCLYLSIWAPRIENIQSQQRPLPVLLYIPGGGFTSGGEASLYKIPDKWVQRTQSHIVVIMNYRVNVFGFPNAEGLSEPNVGLLDQRMAVEWVAANIANFGGDPARIALWGQSAGAASVTAYSYGYPEDPIVAALIADSGAPNIVDNEDYAHTNFTFLASLVGCDGLSSTEELSCMRNVSARKLQTALSTYSGSPSISFTPAVDNKTFFANWTERAITGKVAKIPLITGSNTNEGAGFVSFTPAGPSKSTLFEITESIIACPVAEEVKNRNLANLTTYRYQYAGNFTNISPLPWFGAYHSAELPILFGTHYEYGGPSTQYEWDVSYAMQALWLSFVEDPTRGPVRLAVGNVPANPTNESYFAWPAFEQGSDDLLVFAEGGKVMQLVGAGRIDDYC
What is the function of this protein?
Extracellular chlorogenic acid esterase that releases caffeic acid from chlorogenic acid (CGA) contained in natural substrates such as apple marc and coffee pulp (PubMed:17630312).  Shows no activity towards 5-O-p-coumaroyl quinic acid, another quinic ester derivative, and rosmarinic acid, another caffeic ester derivative (PubMed:17630312).
What are the official names of this protein?
Chlorogenic acid esterase, Chlorogenic acid hydrolase, CGA hydrolase.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOB_RHIL3
Sequence: MAQTLSFNGRRRVRKFFGKIPEVAEMPNLIEVQKASYDQFLMVEEPKGGRPDEGLQAVFKSVFPITDFSGASMLEFVSYEFEPPKFDVDECRQRDLTYAAPLKVTLRLIVFDIDEDTGAKSIKDIKEQSVYMGDMPLMTNNGTFIVNGTERVIVSQMHRSPGVFFDHDKGKSHSSGKLLFAARVIPYRGSWLDIEFDAKDIVYARIDRRRKIPVTSLLMALGMDGEEILDTFYTKSLYKRDGEGWRIPFKPETLKGAKAITEMVDADTGEVVVEAGKKLTPRLLRTLSDKGLKALKAADDDLYGNYLAGDIVNYSTGEIYLEAGDEIDEKTLGIILANGFDEIPVLGIDHINVGAYIRNTLTADKNENRQDALFDIYRVMRPGEPPTMESAEAMFNSLFFDAERYDLSAVGRVKMNMRLDLTVEDTVRILRKDDILAVVRMLVELRDGKGEIDDIDNLGNRRVRSVGELMENQYRLGLLRMERAIKERMSSIEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQVNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATFARVNKYGFIESPYRRIVDGKVTSDVLYLSAMEEAKYYVAQANAEMNADGSFVDEFVVCRHAGEVMLAPRDSMNLMDVSPKQVVSVAAALIPFLENDDANRALMGSNMQRQAVPLLRAEAPFVGTGMEPVVARDSGAAIGARRGGVVDQVDATRIVIRATEDLEAGKSGVDIYRLQKFQRSNQNTCVNQRPLVTVGDEVNRGDILADGPSTDLGDLALGRNALVAFMPWNGYNYEDSILLSERIVADDVFTSIHIEEFEVMARDTKLGPEEITRDIPNVSEEALKNLDEAGIVYIGAEVQPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSMRMPPGTYGTIVEVRVFNRHGVEKDERAMAIEREEIERLAKDRDDEQAILDRNVYGRLIEMLRGQASIAGPKGFKKGSELSNAVVSEYPRSQWWMFAVEDEKVQSELEALRGQYDESKSRLEQRFMDKVEKVQRGDEMPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRIVPVEDMPFLEDGTHVDVVLNPLGVPSRMNVGQILETHLGWACAGMGRQIGELIEAYKANGNIEPLRKTIGDVVGDGPKAEQVHEFDDDSVLRLADQWKRGVSIATPVFDGANEADVNDMLRLAGLKDSGQSTLYDGRTGEQFDRQVTVGYIYMLKLNHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEAGIPESFNVLVKEMRSLGLSVELENTKLDEAQAAQLPDAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CYAY_PHOPR
Sequence: MMNDTEFHKLVDHALMIIEEGIDESGADIESETTGNVLTLEFENRSQIVINRQEPLHELWLASKSGGYHFKYNNGEWHCTRSGEEFFALVKRECSVHAGETVDWS
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: BSK3_ARATH
Sequence: MGGQCSSLSCCRNTSHKTAVLEAPDVDNGESSEITDVPNFREYTLEQLKAATSGFAVEYIVSEHGEKAPNVVYKGKLENQKKIAVKRFTRMAWPDSRQFLEEARSVGQLRSERMANLLGCCCEGDERLLVAEFMPNETLAKHLFHWETQPMKWTMRLRVVLYLAQALEYCTSKGRTLYHDLNAYRVLFDEECNPRLSTFGLMKNSRDGKSYSTNLAFTPPEYLRTGRITPESVIYSFGTLLLDLLSGKHIPPSHALDLIRDRNLQTLTDSCLDGQFSDSDGTELVRLASRCLQYEARERPNTKSLVTALTPLQKETEVLSHVLMGLPHSGSVSPLSPLGEACSRRDLTAMLEILEKLGYKDDEGVTNELSFHMWTDQMQESLNSKKKGDVAFRQKDFREAIECYTQFIDGGMISPTVCARRSLCYLMSDMPKEALDDAIQAQVISPVWHVASYLQSASLGILGMEKESQIALKEGSNLEAKMNGVPRVK
What is the function of this protein?
Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1.  Mediates signal transduction from BRI1 by functioning as substrate of BRI1 (PubMed:18653891).  Functions redundantly with BSK4, BSK6, BSK7 and BSK8 (PubMed:23496207).
What are the official names of this protein?
Serine/threonine-protein kinase BSK3, Brassinosteroid-signaling kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: SYN_STAA8
Sequence: MKTTIKQAKDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEEVFKLAKEITQESSLYVTGTITEDNRSDLGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLWLRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAFLSQSGQLYLEAAAMAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTNHAESLEIQEQYVTHVVKSVLENCKLELKILERDTSKLEKVATPFPRISYDDAIEFLKAEGFDDIEWGEDFGAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPENEETVLCADLIAPEGYGEIIGGSERVDDLELLEQRVKEHGLDEEAYSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAPFPRLLNRLYP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA4_ARATH
Sequence: MEASISFLGSTKPNISLFNPSSNVLPRRDFPLPALKLKKVSVLPRILHQKRLIRAQCSDGFKPEEDDGFVLEDVPHLTKFLPDLPSYPNPLKESQAYAIVKRTFVSSEDVVAQNIVVQKGSKRGVHFRRAGPRERVYFRSDEVKACIVTCGGLCPGINTVIREIVCGLNNMYGVNNILGIQGGYRGFYSKNTMNLTPKVVNDIHKRGGTFLQTSRGGHDTAKIVDNIQDRGINQVYIIGGGGTQKGAEKIYEEVERRGLQVAVSGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEVESVENGVGIVKLMGRYSGFIAMIATLANRDVDCCLIPESPFFLEGKGGLFEFIEERLKENRHMVIVIAEGAGQDYVAQSMRASETKDASGNRLLLDVGLWLTQQIKDHFTNVRKMMINMKYIDPTYMIRAIPSNASDNVYCTLLAQSAVHGAMAGYSGFTVGPVNSRHAYIPISQVTEVTNTVKLTDRMWARLLASTNQPSFLTGEGALQNVIDMETQEKIDNMKISSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase 4, chloroplastic, ATP-PFK 4, Phosphofructokinase 4, Phosphohexokinase 4.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RHO_FIBSS
Sequence: MPRTPKNQNLEQNTQTQSLTDLVYPESTGIPVPEYLGTVDKLPDNTEEVPQPKRRGRKPNPKTKARKEPALEQNVQAETEPEFQEKKQPVDGIAAAEKRLAEQYGVANIDAIAEPIYTGEQNYKPAESTEENAFVSENTSEAVIPQNGDMAQAQAENQGEVATDQNADPNAQQQGEAQAQNGEGQDDRRFNNQNGKFNKFNKNNKFNKNNRNNRNFQQQEEFVDDSATLPAPGSEAILKAKENWLKFRKLSMSELQELAVQKEVDFRRMRKQSLNYILQSLENEGNIIYTEGVLEVTPQGHGFLRMPDQNYQTSADDVYVSQNLIRKFNLKIGDTIEGLVRTPRDQDKYFSMRRIDRVNFEEPDKMRRRVAFEYLTPIHPEEKIHLEWNETEYSTRIMDLFSPIGKGQRSIILAPPRTGKTVLLQNVTRAIAKNHPEIILITLLIDERPEEVTEMRDIITDIKEKAAEKGIEIKAEVVASTFDEPPEHHTRVANMVLEKAKRLVESQKDVVILLDSITRFARANNVVIPHSGKILSGGVDANAMQFPKKFFGAARKIQDKIRTVKNEDGTISEEVQKNGSLTIIGTALIETGSRMDEVIFEEFKGTGNMELVLDRRIAEKRIWPAIDVFKSGTRKEERLLTLLEQNAAWNFRRGSQNETETGIMENLLKLMSKLKTNAELLAVLSKPKV
What is the function of this protein?
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
What are the official names of this protein?
Transcription termination factor Rho, ATP-dependent helicase Rho.
What is the protein family that this protein belongs to?
Belongs to the Rho family.
Protein: GCSPA_HALHL
Sequence: MPFVPHTEQEVREMLDAIGVERIEDLFDEIPESLRKASIDAIPAGMNEMEVTQLMRRRAAQDVQPACFVGAGAYDHHVPAAVWEITTRGEFYSAYTPYQAEASQGTLQLLYEFQTMMSELTGLYASNASLYDGATALAEAVLMAVRANRKVKSKRVLMPRSVHPYYRRVVETIVANQGIELVEAPLDDTVGRIDPEALGRFEDEPFAAVVIPQPNFFGALEEVDRLTDWAHGLNALVIAVCNPVALALLTPPGEWGTEGADIACGEGQPLGIPLSSGGPYFGYMTTRKQHVRQLPGRIVGRTVDADGRTGYTLTLQAREQHIRRSKATSNICTNQGLMVTAATVHLSLLGAEGLARVAAVSHERTRELVQKLTAIDGVERLFDGPFFHEVPVRIPAPAEEVLPMLANRGVLGGYDLSQEFPEWGPALLICATETRTSEEIDRFAAALADALRNTGQRARA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: FABZ_GLUDA
Sequence: MDKEVEVPPAGDSPTCIEAIDVMRIMEAIPHRYPFLLIDRMVDIVLGSSAVGIKNVTASEPHFQGHFPARPVMPGVLIIEAMAQTAATLVVLTLGPAFEGKLVYFMTIDGAKFRRPVGPGDQLRIHVEKERSRANVWKFKGIARVDGVSVAEATFSAMIMG
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_NEIMB
Sequence: MKSVRSFIRDDIQAMSAYQIADVPPGFAKLDSMESPVHPFAGHETLLQEWQARLAAAPIHLYPNPSGSGLQEALRSAFDIPDCADIALGNGSDELIQFITMLTAKPGAAMLAAEPSFVMYRHNAALYGMDYVGVPLNGDFTLNLPAVLEAVRKHRPALTFIAYPNNPTGVCFTRAEIEAVIEASDGIVVVDEAYGAFNGDSFLPQAGRIPNLIVLRTLSKIGFAGLRIGYAAGCPEVIGELQKILPPYNMNQLSLTTAKLALRHYGIISANIDSLKNERERMFAELGKICRLNTFSSQANFITIRVPDADLLFDTLKQNRILVKKLHGAHPLLEHCLRITVGSPAQNDAVLNIIRQLYCQPTDFL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: SRBP2_MOUSE
Sequence: MDESSELGVLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGGGSNGGSGNNSSGRGNNGGATDPAVQRSFSQVPLSTFSPSAASPQAPALQVKVSPTPPRATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSPQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQLDPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNTDQHPYSGSGRSVLSLESGAGGWFDWMVPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRPSVTFWRHRKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKILPSTLIEIHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCGPEHSTVPDSLRWLCHPLGQKFFMERSWSIKSAAKESLYCAQRSPADPIAQVHQAFCKNLLERAVESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGFVTSPFSSSSVLRSALGPDVICRWWTSAVTMAISWLQGDDAAVRSRFTEVERVPKALEVTESPLVKAVFYTCRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVIQLFTCDLLLSLRTALWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRPTQNTKHGEVDTWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS
What is the function of this protein?
Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:9616204).  Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3').  Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity).  Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:9616204).
What are the official names of this protein?
Sterol regulatory element-binding protein 2, SREBP-2, Sterol regulatory element-binding transcription factor 2.
What is the protein family that this protein belongs to?
Belongs to the SREBP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (By similarity). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (By similarity). SUBCELLULAR LOCATION: [Processed sterol regulatory element-binding protein 2]: Nucleus. Note=Transported into the nucleus with the help of importin-beta (PubMed:10397761, PubMed:11283257). Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import (PubMed:10397761, PubMed:11283257).
Protein: GCSPB_STAA2
Sequence: MTSKSSPLIFERSREGRYAYSLPKSDIKTNSVESLLDDKFIRKNKAEFPEVAELDLVRHYTELSNKNFGVDNGFYPLGSCTMKYNPKINEKVARIPGFSESHPLQDEDQVQGSLEIIYSLQEELKEITGMDEVTLQPAAGAHGEWTALMIFKAYHENNGEGHRDEVIVPDSAHGTNPASASFAGFKSVTVKSNERGEVDIDDLKRVVNENTAAIMLTNPNTLGIFEKNIMEIREIVHNAGGLLYYDGANLNAIMDKVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVVKELASYLPKPMVIKDGDKFKYDNDIKNSIGRVKPFYGNFGIYLRAYTYIRTMGATGLKEVSEAAVLNANYIKARLSEHFEIPYKQYCKHEFVLSGVRQKEFGVRTLDMAKRLLDFGVHPPTIYFPLNVEEGMMIEPTETESKETLDYFIDTLISIAEEAKNDPDKVLEAPHTTVIDRLDEATAARKPILKFENLKQEK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: KUP_ECO81
Sequence: MSTDNKQSLPAITLAAIGVVYGDIGTSPLYTLRECLSGQFGFGVERDAVFGFLSLIFWLLIFVVSIKYLTFVMRADNAGEGGILTLMSLAGRNTSARTTSMLVIMGLIGGSFFYGEVVITPAISVMSAIEGLEIVAPQLDTWIVPLSIIVLTLLFMIQKHGTAMVGKLFAPIMLTWFLILAGLGLRSIIANPEVLHALNPMWAVHFFLEYKTVSFIALGAVVLSITGVEALYADMGHFGKFPIRLAWFTVVLPSLTLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLIIAALATVIASQAVISGVFSLTRQAVRLGYLSPMRIIHTSEMESGQIYIPFVNWMLYVAVVIVIVSFEHSSNLAAAYGIAVTGTMVLTSILSTTVARQNWHWNKYFVALILIAFLCVDIPLFTANLDKLLSGGWLPLSLGTVMFIVMTTWKSERFRLLRRMHEHGNSLEAMIASLEKSPPVRVPGTAVYMSRAINVIPFALMHNLKHNKVLHERVILLTLRTEDAPYVHNVRRVQIEQLSPTFWRVVASYGWRETPNVEEVFHRCGLEGLSCRMMETSFFMSHESLILGKRPWYLRLRGKLYLLLQRNALRAPDQFEIPPNRVIELGTQVEI
What is the function of this protein?
Responsible for the low-affinity transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Low affinity potassium transport system protein Kup, Kup system potassium uptake protein.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATAS1_HUMAN
Sequence: MAHFKDDLQTNVEIIPGESAPRKESPRPPAPPSSAAGVGGCSNHSPSVQESPLSPPALAQLGSAQQPSMRTELSFSEKKDTMIIWQITITVWCQR
What are the official names of this protein?
Putative uncharacterized protein ATP1A1-AS1, ATP1A1 antisense RNA 1, ATP1A1 antisense gene protein 1, ATP1A1 opposite strand protein.
Protein: RS12_PROM2
Sequence: MPTISQLVGSERKRLTKKTKSPALKACPERRGVCTRVYTSTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVLLRGGRVKDLPGVRYHIIRGTLDTAGVKDRRQSRSKYGAKAPKD
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: EF2_THEVO
Sequence: MGRKEDNIEKALRIVEHTELVRNIGIVAHIDHGKTTLSDNLIAGAGMMSEELAGKQLVLDYDEQEQARGITINAAVASMVHAFQGKEYLINLIDTPGHVDFGGDVTRAMRAVDGVIVVVDSVEGVMPQTETVIRQALREYVKPVLFINKIDRLINELRLNSDEMQKRFTKIISDVNKLISKYAPKEFTKEWQVSVQDGKVAFGSAYNNWAISVPSMAETKITFKDIVEYVKNGKQKELAQKNQLHKIILNMVIRHLPDPKTAQSYRIKQIWKGDLETEVGKSMVSCDFKGPVAMMVTKIIIDPHAGEIAIGRLFSGTVKKGTDLYISGDGKGKVQTLAMMVGPDRIPVEEVTAGNIAAIVGLKGAIAGSTVSSIENMEPFEPMIHYSEPVVTLAIEAKHTADLPRLIDVLRDISKADPSIQVDINQETGEHLISGMGELHLDVTLYRIKNDYKIEVETSEPIVVYRETVEKKGGPFEGKSPNKHNRFYFEVEPLKPEVIQAIEDGDIPQGSKFKDKKTIIETLVSKGIDREEARGLVCVEGTNIMFDVTRGIQYLDETMELLIEAFTEVMNRGPLANEKVFGVKARLVDAKLHEDSIHRGPAQVIPAGRNSIYGAMCEAKRILLEPVQKVFINVPQEEMGSAINEVQQRRGVIEDMTQEGEEVSLVARIPVSGMFGFASAIRSATGGKVLWSFENAGYQKVPPELQDSVVRSIRERKGLRPEPYDADYYASM
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_LEGPH
Sequence: MSDSTTIARPYAKAIFEHALAEKKLSEWSEYLTLLAQVVLTPQATQFIANPASTDEQQIELLIEVCGSKFKKNDALNNLIKLLTTNKRLMLLPEIEALYEVYRAEQEKILEVDVVSYSELTPAQQQRLSESLSQRLSRKVSLKISIDPSLLGGALIRAGDLVIDGSVRGKLNMLGTSLAA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: IHFB_SHEFN
Sequence: MTKSELIEKLATRQSQLSAKEVESAIKEMLEQMATTLETGDRIEIRGFGSFSLHYRAPRTGRNPKTGTSVDLEGKYVPHFKPGKELRERVDAVNP
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.