PharMolix/UniProtQA huggingface dataset:
Protein: DPOL_ABVP
Sequence: MLQILNNANDKIQYKLNDFSDLTPSFKIKSGFFTIHRINYEKLEENEEEKPRQISAFDIETNGREIFFGVYDGSEYKYVIIRKPEDVKNALDLLTEETYFYGDYDLPVSLANYVLLGKHSKFAKKITGENYFTTKNLRIKRYKNFYKILYNGRSINSINLLQFYSESLYEAYSRYYTKLQEMGFQVFDEQTMKEWKEDKEKRANFDKLDFNDPKTIQEIARYNKLDVIATYQLALLKNSLFGIKVKSTLPRTAITYIISQVQSEFVKGLRSYTEIELTLKRLYKGGLFDSNELGKFKKVYKYDVNSMYPFMMSWLPELELVETQKGFEVNEEPLLKGTQFNEDAKYVYIYKITLKQDRKYVASKANGMLLRMMYNRGSFFDFELADEKHELIPDIKIVGQYYTMKFKITKHRIFKDVIYNLYNKRLQLKKEKNPLEKVYKLILNSSYGKFGERIGFNAKFQNVIYASMITALGRTFIQNVDPNAISYLTDSVISKAPIKSELVGDQLGQLKQEGVGEAIVIGNGQYILNDPQEKMIKLRGFNVDESIAEKIIEYVGNYLAKGKIVRVQIPTKIMIRNLQQYKILAEKDSNVLMGMLSNQIKIFTPLNTKQRYTYNVHWFGSMFRDEQEHKEYRKTWEKYIETIEPIDLNSILS
What is the function of this protein?
Replicates viral genomic DNA.
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: PHND_MYCS2
Sequence: MKIRAHHKIATAAACVALLASACSGSDKPQSTTAEGFPETITLAAIPAENSSDLKASYDPLIKMLEKQTGSKVEFVQASDYAGVVEGMIAGNVDLAFFGPFAYVVAGVNGAKMTPLGAVIKDEGGAPGYQSYGLARADEDNINGLKDFAGKKVCFVDPGSTSGFLYPTAGLIEEGVVKSGSEADISAAMSPIFAGGHDSSALAIANGDCDAGFAFDTMVDKTMIDKGDLKPGQLKTVWKSDMIAGSVFAANDALGPEVIDKLKTMFAQDANVKSFEEEGFCEGDACRITDERAWGVVPVTDADYDGVRHVCDVTGSEKCKG
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphate import.  Responsible for phosphate binding.
What are the official names of this protein?
Phosphate-import protein PhnD.
What is the protein family that this protein belongs to?
Belongs to the phosphate/phosphite/phosphonate binding protein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PTH_ELUMP
Sequence: MIKLIVGLGNPGPQYAVTRHNAGFMIVDNLAVKLGVNFNAYKNLGEYVKTTIGGQDVFLAKPLTFMNLSGRMVTHLAGFYKIKPQEILVCFDDISINLGAVRIRKDGSAGGQNGMKNIIELFGTQDIPRLRFGVGPKPERFDSADYVLSKFSKSDEKLLNESIEAAVEAAESCVKDGLERAMNKFNK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y9752_DICDI
Sequence: MSSIDYLVNNCDYKVSAFSLNDGQRSNSIQPVSQNDQEMCYLGDIDYGCTIIYPNGKKH
What are the official names of this protein?
Putative uncharacterized protein DDB_G0292534.
Protein: ISOC2_XENLA
Sequence: MSSLRRIGKLGERSSVLFLCDMQEKFRKSIVFFPEIVSVAARMLQAAKKLEMPVIITEQHPKGLGPTVPELGADDLKKYTKTSFSMLTPEVEEELQSIPDLRSIVLCGIETQACIMSTALDLLDKGYDVHVVADACSSRSQVDRLFALSRMRQSGAFLTTSEGVLLQLLGDAKHPKFKEVQKIIMEPAPDSGLLSLFRGPNLFST
What are the official names of this protein?
Isochorismatase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family.
Protein: YCIB_BRUO2
Sequence: MEHPVFERDPSEKSETERREVPPLLKLALELGPLLVFFFANARGEMLIERFPILGSIGAPIFLATALFMAATVIALAISWSMTRTLPIMPLVSGIVVLVFGALTLWLHNDTFIKMKPTIVNTLFGGILLGGLFFGKSLLGYVFDSAFRLDAEGWRKLTLRWGLFFIFLAIVNEIVWRNFSTDTWVSFKVWGIMPITIVFTLLQMPLIQKHSLTDEENTAS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HGPRT_STAAN
Sequence: MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
What are the official names of this protein?
Hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQOR_AZOVD
Sequence: MKKILVLYYSMYGHIERMAEAVAEGARSVPGVEVTLKRVPETMPEEVARKAGAKLDQAAPPAEPKELADYDAILFGTPTRFGNMAGQMRNFLDQTGGLWVSGALVGKFASVFTSTGTGGGSETTITSFWHTLAHHGMVIVGLPYVLPELSDVSEPRGGSPYGAATIAGADGSRRPSEKELILASFQGAHVARLVVRMQ
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: CLPP_CLOPS
Sequence: MSNLVPMVVEQTSKGERSYDIFSRLLKDRIIMLSGEVNDVTANLVVAQLLFLESEDPDKDIHLYINSPGGSITSGMAIYDTMQYIKPDVSTICIGMAASMGAFLLSSGAKGKRFALPNAEIMIHQPLGGFQGQATDIDIHAKRILKIKDKLNQILSENTNQPLEKIKVDVERDYFMEASEAVEYGLIDKVIERK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_EHRRG
Sequence: MCIVKTLHLITHVMKEYNSQFTEGSDFSLIEEQILEFWKENNIFKKSIENRDEKRRFVFYDGPPFANGLPHYGHLLTGFIKDTVARYKTMAGFRVDRRFGWDCHGLPAEMLAEKELGVSGKLAIEEFGIEKFNNYCRNSVMKFSREWKQYIDRQSRWVDFENDYKTMNLSFMESIMWSFYQLWQKGLIYESIKIVPYSWACQTPLSNFETRIDNAYRQKTSKTVTLAFELLDAPKSLIVDNITAYKILVWTTTPWTLPCNLALAISPNIKYCGAIINKEMYIFSRAYLKNFEDHCKKNNIEYLIHSDDICYLSLEYLSYKPVFNYFIDIKNAFKVLVADFVVEDEGTGIVHMAPGFGEDDFILCKKQGIPDIDDKDTSKLLATICPIDDGGKFTERISDFVNMHVFDTNDQIISILKAKNLCFKTDQYLHNYPHCWRTDTPLIYRAMSSWYVEVTKIKNRMIDLNKDVNWIPSHIRSGQFGKWLENAKDWAISRNRFWGTPLPVWKSDNPNYPRIDVYGSIKKVFDDIKALEEDFDIPIDDLHRPYIDNLVRPNPDDPTGKSMMRRVTDVFDCWFESGSMPYAQLHYPFENKELFENYFPADFITEYVAQTRGWFYTLFVLSTALFDKPPFKNCICHGVVLDTQGQKLSKRLNNYADPMEIFKQYGSDAMRFLMLSHTVSYGGDLLLDKDGVMVRDVIRNVIKPMWNSYNFFTIYADIDKVSARVISDLDEVDNIMDKYIMCECISTIQSIFNAMEEFDQSVGNYGYNIKAACNSIVQFFEVLNNWYIRRCRSRFWSSEITKDKVNAYNTLYTVMYYMVKVSAPFLPAITEAIWQKLNFQEEESVHLSLLPNIEHITLKDEDQKNIQYMKLIINICGCVLSIRNVRNIRVRQPLNKITIYSYNNNNDLFNLPVKYQNILLDEINVKSIVFKSNIEDIASFQLKLNFPELGKRIPEKMKNLISLLKSNQWKVLENGQLMLGIREGEYYILEDNEYTLNLKVHSEFASTITLGPNLLGVLVLDNTLTDELIMEGIARDIVRIIQQSRKDNKFNVSDKIDVVICTQDKMVKNSVQAWYEYIVQQTLSLSLVIHENLDANNVAEYCKTTMKDRNLTLFIKKL
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_SHIB3
Sequence: MTAPSQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHNFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSIDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREAHFIESVMEPLRQRLTALKVVFEHITTKDAADYVHDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVKQ
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: PP1RA_RAT
Sequence: MGSGPIDPKELLKGLDSFLTRDGEVKSVDGIAKIFSLMKEARKMVSRCTYLNIILQTRAPEVLVKFIDVGGYKLLNSWLTYSKTTNNIPLLQQILLTLQHLPLTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVIRSQSSTQPAEKDKKKRKEEGKSRTTLPERPLTEVKAETRAEEAPEKKKEKPKSLRTTAPSHAKFRSTGLELDTPSLVPVKKNSSTVVVSDKYNLKPIPLKRQSATAAPGDAAPPAEKKYKPLNTTPNTTKEIKVKIIPPQPMEGLGFLDALNSAPVPGIKIKKKKKVLSPTAAKPSPFEGKTSTEPSTAKPSSPEPAAPAEPMDTDRPGTPVPAVEVPELMDAASSEPGALDAKPVESPGDPNQLTRKGRKRKTVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFETARRLSHDNMEEKVPWVCPRPLVLPSPLVIPGSNSQERYIQAEREKGILQELFLNKESPHEPDPEPYEPIPPKLIPLDEECAMDETPYVETLEPGGSGGSPDGAGGSKLPPVLANLMGSMGAGKSPQGPGGGGINVQEILTSIMGSPNNHPSEELLKQPDYSDKLKQMLVPHGLLGPGPVANGFPPGGPGGPKGMQHFPPGPGGPMPGPHGGPGGPVGPRLLGPPPPSRGGDPFWDGPGDPMRGGPMRGGPGPGPGPYHRGRGGRGGNEPPPPPPFRGARGGRSGGGPPNGRGGPGGGGMVGGGGHRPHEGPGGSMGSGHRSHEGPGGSMGSGHRSHEGPGHGGPHGHRPHDVPSHRGHDHRGPPPHEHRGHDGHGGGGHRGHDGGHSHGGDMSNRPVCRHFMMKGNCRYENNCAFYHPGVNGPPLP
What is the function of this protein?
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex.  The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.  Mediates interaction of WDR82 and PPP1CA.  Inhibitor of PPP1CA and PPP1CC phosphatase activities.  Has inhibitory activity on PPP1CA only when phosphorylated.  Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.
What are the official names of this protein?
Serine/threonine-protein phosphatase 1 regulatory subunit 10, MHC class I region proline-rich protein CAT53, Phosphatase 1 nuclear targeting subunit, Protein PNUTS.
What are the subcellular locations of this protein?
Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity).
Protein: CCME_LARHH
Sequence: MHPKRKKRLLIVLAGLAVVAVASGLILNAFRSNLVFFHTPTEIAAGQVDTDRVIRVGGLVEAGSVEREPGGLRVRFVITDTARSVPVRYEGILPDLFREGHGTVVQGRIGTDGVLAATQVLAKHDENYMPPEAADAIQRAGETVVQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: Y1587_METJA
Sequence: MKADLHIHTKYSGIGKFWKLKFPDSVEEPRNILKVAKKKGIEVVAITDHNTIRGGVETKKLEKEFGVEVVIGSEIMTTEGEIIGLFLNEDIPKGLSPEETIEKIKEQGGLAIAPHPYSPICKALGDRIFDLDLDGVEVFNAYHRDGIVNNIALNKVIKELPQKAFCIYWRE
What are the official names of this protein?
Uncharacterized protein MJ1587.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0417.
Protein: PANC_ECO57
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIIAIAGQELNEKGFRADDIQIRDADTLLEVSETSKRAVILVAAWLGDARLIDNKMVELA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y491_MYCPN
Sequence: MKLTLWLVLGAVGVGAVGTGVGFGTKYFLDHKAKSNVDVAFKQRSLRKQVNVGFWNALNFLGSERSFGNQNSKVKTKGIAEIINLLKYDIVGLAEIQPSTESTAERFVDQLNEYADPYTSWSYDLSPVTTSKTASEGQKERILIVYNSQSVKMEGQGWFYDNPEMDISNYVSDGSSSKTRTPKKTKTSKKKPIKKKSSKSKSSKGSKKQKTTNESESETLELKLEQRRVTTRSQSKQQKGQEQATDQTDSEGVTTEEGADNTDTELVETTAETTEQEATTKSTKDTKETKDRTKVDWSRPPYSAEFSTQKGKVVVAFGHFDSPGANTKRGEKIAKMGKGQGAHEYFEAQTTFKAMDSIKQHFNNENILFMADTNIKFGNQAAAFGESKDYTFLTEDNEAWKSSLGTKSGYANPYDKIITSNSFKNKVLDQAETYWNYFDRYLKTKGHNSYLFDLASWGTKPRTISDHAPVGVLF
What are the official names of this protein?
Uncharacterized protein MPN_491.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TPIS_BACFR
Sequence: MRKNIVAGNWKMNKTLQEGIALAKELNEALANEKPNCDVIICTPFIHLASVTPLVDAAKIGVGAENCADKESGAYTGEVSAAMVASTGAKYVILGHSERRAYYGETVEILKDKVKLALANGLTPIFCIGEVLEEREANKQNEVVAAQLASVFDLSAEDFSKIVLAYEPVWAIGTGKTASPAQAQEIHAFIRSAVAEKYGKEIADNTSILYGGSCKPSNAKELFANPDVDGGLIGGAALKVADFKGIIDAFN
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MASTE_EUMFR
Sequence: FDVMGIIKKIAGAL
What is the function of this protein?
Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane.  Has antibacterial activities against both Gram-positive and Gram-negative strains.  Has more potent activities against the yeast C. albicans.  Shows moderate mast cell degranulation and leishmanicidal activities.  Has a very low hemolytic activity.
What are the official names of this protein?
Eumenine mastoparan-EF, EMP-EF.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Mastoparan subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Assumes an amphipathic alpha-helical conformation in a lipid environment. Forms a membrane channel in the prey (By similarity).
Protein: GHITM_HUMAN
Sequence: MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKIDQMGRWFVAGGAAVGLGALCYYGLGLSNEIGAIEKAVIWPQYVKDRIHSTYMYLAGSIGLTALSAIAISRTPVLMNFMMRGSWVTIGVTFAAMVGAGMLVRSIPYDQSPGPKHLAWLLHSGVMGAVVAPLTILGGPLLIRAAWYTAGIVGGLSTVAMCAPSEKFLNMGAPLGVGLGLVFVSSLGSMFLPPTTVAGATLYSVAMYGGLVLFSMFLLYDTQKVIKRAEVSPMYGVQKYDPINSMLSIYMDTLNIFMRVATMLATGGNRKK
What is the function of this protein?
Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18417609, PubMed:36321428, PubMed:32977469, PubMed:35912435).  Mediates proton-dependent calcium efflux from mitochondrion (PubMed:36321428, PubMed:35912435).  Functions also as an electroneutral mitochondrial proton/potassium exchanger (PubMed:36321428).  Required for the mitochondrial tubular network and cristae organization (PubMed:18417609, PubMed:36321428, PubMed:32977469).  Involved in apoptotic release of cytochrome c (PubMed:18417609).  Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (PubMed:36321428).  However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (PubMed:36321428).
What are the official names of this protein?
Growth hormone-inducible transmembrane protein, Dermal papilla-derived protein 2, Mitochondrial morphology and cristae structure 1, MICS1, Transmembrane BAX inhibitor motif-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the BI1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MIAB_BACSU
Sequence: MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGKEAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDDANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKHPFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIMYGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFEDMTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSEVLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEFDSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVLVEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEVK
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_FRATF
Sequence: MKQITIASRESKLALWQTNFVKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCHVAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: LIPA_AZOC5
Sequence: MVTVVNTLNRPRHPEKQNRPETEVLRKPDWIRVKAPGSAGWSNTAGIVRANGLHTVCEEAGCPNIGECWEKKHATFMIMGDTCTRACSFCNVRTGMPKALDLDEPQKVGEAVAKLGLSHVVITSVDRDDLTDGGAEHFARTIASIRKLSPGTTIEILTPDFLRKPGAIEVVVAARPDVFNHNLETVPGKYLTVRPGARYFHSLRLLQQVKELDPSIFTKSGIMVGLGEERNEVLQLMDDLRAAEVDFMTIGQYLQPTRKHHKVERFVTPDEFKAYETVAYAKGFLMVSSSPLTRSSHHAGDDFAKLRAAREAKLGRI
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_BURCM
Sequence: MSIKSDKWIRRMAEEHKMIEPFVPDQVRASEDGRRIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEGSFVDFKGDVCIIPPNSFALARTVEYFRIPRTVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVLFFESDEVCDVSYADRGGKYQGQRGVTLPKT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: LRCC1_MOUSE
Sequence: MEAAVCSEIEREDGDSSCGDVCFMDKGLHSISELSLDSSIHAINLHCNNISKISSIDHIWNLRHLDLSSNQISQIEGLNTLTKLCTLNLSCNLITRVEGLEALVNLTKLNLSYNHINDLSGLMPLHGLKYKLRYIDLHSNYIDSIHHLLQCTVGLHFLTNLILEKDGEGNPICLIPGYRAIILQTLPQLRILDCKNIFGEPVSLEEINSSHLQCLEGLLDNLVSSDSPLNISEDEVNDDVPAPPMDVLPSLKEFKSTPEDNVLASLLSVCPSSEPEKINQENDFQNEVKLQKLDDQILQLLNETNNSLIDNVPEKDLRPKRDTDITSESDYGNRRECSRKVPRRTKIPYYARTIQTIKHHNKNNGAFVSCNRKMRQPYLRDLYVRSSLVNCNNLRDLDEQKTGVIKVDKNFSDNSTYRSLVEQLDQEREMRWKAEQTEKKLMDYIDELHKQADEKKDVHSQALITTDRLKDAIFKERHCKAQLEIIVHRLQNEVKKLTIELMKARDQQEDHIRHLRTLERALEKMEKQKAQQQAAQIRLIQEVELKASAADREINLLRTSLHQEKQQVQQLHELLALKEQEHRQEIETRQFFTDAEFQDALTKRLCKEERKHEQEVKEYQEKIDILNQQYLDLENEFRIALTVEARRFKDVQDGFEDVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLSEVCKLKQEAAANLQNQINTLEILIEDDKQKSIQIELLKHEKTQLISELAAKESLIYGLRTERKVWGQELACQSSTLSQSRGKLEAQIESLCRENESLRKSHESDCDALRIKCKIIEDQNETIRKLKDSLQEKDGQIKLLQEQIALIEKCSQEQLNEKSSQLDSIVEKLERHNERKEKLKQQLKAKELELEEIRKAYSTLNKKWHDKGELLSHLEMQVKEVKEKFEDKERKLKAERDKSLELQKDAMEKLQNMDDAFRRQVDEIVEAHQAEIMQLANEKQKYIDCANLKVQQVEDEMRGLLDETCKNKKMMEEKIKQLACAISEIQKEM
What is the function of this protein?
Required for the organization of the mitotic spindle.  Maintains the structural integrity of centrosomes during mitosis (By similarity).
What are the official names of this protein?
Leucine-rich repeat and coiled-coil domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the LRRCC1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Associates with the centrosome throughout the cell cycle and extensively accumulates during the mitotic phase.
Protein: FABP_SCHMA
Sequence: MSSFLGKWKLSESHNFDAVMSKLGVSWATRQIGNTVTPTVTFTMDGDKMTMLTESTFKNLSCTFKFGEEFDEKTSDGRNVKSVVEKNSESKLTQTQVDPKNTTVIVREVDGDTMKTTVTVGDVTAIRNYKRLS
What is the function of this protein?
May play a role in the transport of fatty acids.  Binds various fatty acids, such as arachidonic, oleic, palmitic and linolenic acid (in vitro).
What are the official names of this protein?
14 kDa fatty acid-binding protein, Sm14.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG430_BPPF3
Sequence: MIRSIIALMLSFALVPFAFASDRLTVKHHEIDIRVAIPLVADFCGRSVVLGPSIQGVVSLDFDDVPCSQAFDLLLESNHLLSSMVGDVLVITAMDQVLNSERKADDLRTFRRDLFNANDIERRVINIVHASASEVVSLFKESFMSLDAPGMSMTVDERTNSVFAALPSSFFPALESVIQAIDVPVRQVAIEANVVEASVDWSKRLGLNWGGALSLGNWSAVTAGDLSVAAGSSIGFGFLSNTLSLDGLFTAMENEGNGRVVSRPTLLTLDRQSASVLRGTELPYQQSAGDGATSVAFKHAALSLEVKPVISPDNSIVIEVLVSRDSPNFSNAIDGVPPIDTNRLVTTIRVPHGQTVVLGGVYSTINQQGSSRVSGISRIPGIGRLFKKKEHVTEQYELLIFLTPRILGLEVEPEKQSLVFDESFFLGDLF
What is the function of this protein?
May play a role in phage assembly.
What are the official names of this protein?
Putative assembly protein ORF430, ORF430.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: ARTE_METJA
Sequence: MGSLLMERNFMVEDTFTNGKLSKKEKILFLIKFYIIFLVVFFILSYFGKYLIGIVTYLSYIFTKIIISDARLADNFIYLPNNTVEVVEECTGSFLIAGLLALIIVYSKNIKEFIIGIFFVLLAFFVNIFRIVLICYLVNMHPESSYLYHEIAGYGVILTLVPVLVIGYLKIIEKYRHSSNKSHL
What is the function of this protein?
Transpeptidase that recognizes and modifies its substrate by proteolytic cleavage of a sorting signal.  Following cleavage, a covalent intermediate is formed via a thioester bond between the archaeosortase and its substrate, which is then transferred and covalently attached to the cell membrane.
What are the official names of this protein?
Probable archaeosortase E.
What is the protein family that this protein belongs to?
Belongs to the exosortase/archaeosortase family. Archaeosortase E subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.