PharMolix/UniProtQA huggingface dataset:
Protein: RNPA_FINM2
Sequence: MDKSVRLRDNREYNVVYKRGKTYYNRNFSLVVYNSKKGTRIGFSVTKKYGNAVERNRIKRKLREIVRLNFSEFDKGLDMVIIPKKNTEDLTYKQLESALLHVCRKASNKKCQK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: OBG_LEUCK
Sequence: MAFVDQAEIEVKAGKGGDGIVSFRHEKFVAMGGPFGGDGGHGGSIIFKVDEGLRTLMDFRYNRHFKAQPGGNGGTKGMTGASAEDRYIKVPQGTTVKDVETGEVLGDLLENGQELVVVKGGRGGRGNIHFATPANPAPELSENGEPGQVRKLKLELKVLADVGLVGFPSAGKSTLLSVVSNAKPKVAAYHFTTLSPNIGMVRLDDARDFVMADLPGLIEGASQGVGLGFQFLRHVERTRVVLHLVDMSGIEGNDPYTQYRKILDELGQYDETILNRPHIVVPTKMDMPDSEENLVKFRQEVAADSGLPVQPEIMPISALTREGVQPLMRLTADLLATAPVPESYRPVVEKVSNDKTYDFKPEQHNFTVEWSEETEEWVIGGAEIEKLFLMTNIQRDATIMRFGRQLRHMGVDDALRKAGAKDGDDVRINNSDFVFEFSD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOC_CLOTE
Sequence: MEIQKFIDHTILKPEATEEQVKKLCKEARDYKFASVCVNPYYTSLVSKELQGTDVKTCVVIGFPLGANTKEVKAFETKQAIENGAKEVDMVINIGALKDKKYDVVKEDIEAVVNEAKGKALVKVIIETCLLTDEEKVKACEISKEVGADFVKTSTGFSTGGAKKEDVKLMRETVGENIGVKASGGIRDYKTSLEMIEAGANRIGASAGIKIVEESK
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN283_HUMAN
Sequence: MESRSVAQAGVQWCDLGSLQAPPPGFTLFSCLSLLSSWDYSSGFSGFCASPIEESHGALISSCNSRTMTDGLVTFRDVAIDFSQEEWECLDPAQRDLYVDVMLENYSNLVSLDLESKTYETKKIFSENDIFEINFSQWEMKDKSKTLGLEASIFRNNWKCKSIFEGLKGHQEGYFSQMIISYEKIPSYRKSKSLTPHQRIHNTEKSYVCKECGKACSHGSKLVQHERTHTAEKHFECKECGKNYLSAYQLNVHQRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGVKSYKCKECGKAFFWGSSLAKHEIIHTGEKPYKCKECGKAFSRGYQLTQHQKIHTGKKPYECKICGKAFCWGYQLTRHQIFHTGEKPYECKECGKAFNCGSSLIQHERIHTGEKPYECKECGKAFSRGYHLSQHQKIHTGEKPFECKECGKAFSWGSSLVKHERVHTGEKSHECKECGKTFCSGYQLTRHQVFHTGEKPYECKECGKAFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGEKPFKCKECGKAFSWGSSLVKHERVHTNEKSYECKDCGKAFGSGYQLSVHQRFHTGEKLYQRKEFGKTFTCGSKLVHERTHSNDKPYKYNECGEAFLWTTYSNEKIDTDETL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 283, Zinc finger protein HZF19.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ILVC_BURCM
Sequence: MNVFYDKDADLSLIKGKQVTIIGYGSQGHAHALNLKDSGVNVTVGLRKDGASWSKAENAGLSVKEVAEAVKGADVVMMLLPDEQIADVYAKEVHANIKQGAALAFAHGFNVHYGQVIPRADLDVIMIAPKAPGHTVRGTYSQGGGVPHLIAVAQNKSGAARDIALSYAAANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYEGGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLTDIQTGEYAKSFILENKAGAPTLQSRRRLTAEHQIEQVGAKLRAMMPWIAKNKLVDQTKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: PG164_VAR67
Sequence: MILVPLITVTVVAGTILVCYILYICRKKIRTVYNDNKIIMTKLKKIKSSNSSKSSKSTDNESDWEDHCSAMEQNNDVDNISRNEILDDDSFAGSLIWDNESNVIAPSTEHIYDSVAGSTRLINNDCNEQTIYQNTTVINETETIEVLNEDTKQNPSYSSNPFVNYNKTSICSKSNPFITELNNKFSENNPFRRAHSDDYLNKQEHDDIESSVVSLV
What is the function of this protein?
Involved in the intracellular transport and egress of virions to the host cell surface with help of protein OPG056.  Participates also in the formation of actin tails at the plasma membrane to allow efficient actin-based motility and thus cell to cell transmission of viral particles.  Recruits host intersectin-1/ITSN1 and activates host CDC42 to drive ARP2/3-mediated actin polymerization.
What are the official names of this protein?
Protein OPG164.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG164 protein family.
Protein: RS8_THEAQ
Sequence: MLTDPIADMLTRIRNATRVYKESTEVPASRFKEEILKILAREGFIKGYERVEVDGKPYLRIHLKYGPRRQGPDPRPEQVIKHIRRISRPGRRVYVGVKEIPRVRRGLGIAILSTPKGVLTDREARKLGVGGELICEVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: FUR_STAEP
Sequence: MNTNDAIKILKDNGLKYTDKRKDMLDIFVEEDKYLNAKHIQQKMDKDYPGISFDTVYRNLHLFKDLGIIESTELEGEMKFRIACTNHHHHHFICENCGDTKVIDFCPIEQIKQYLPNVTIHTHKLEVYGVCESCQKNA
What is the function of this protein?
Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
What are the official names of this protein?
Ferric uptake regulation protein, Ferric uptake regulator.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_SYNC1
Sequence: MSRVCDICGKKPTTGNNVSHAHNKTRKVWYPNLQKVRALHKGKVQAIKVCTRCLRSGAVTKAI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: BIOD_CROS5
Sequence: MTTLFIVGTDTEVGKTVVTSALAAYWQTYHSSESLGVIKLLQTGIGDVEHYQRLLPHVEVVNPLRYETPVAPPVAAEKENRSIPLDQVWQGLNDLQQRKNLVLAEGLGGLGSPVTWELTVADLAGEWGLPTVLVVPVKLGAIAQTVANVALARQYKVNLKGIIFSCPRPLSHEEIVNFAPITLIESLTKTPVLGMISYLENIEDITKLAHIASSLDLEMLF
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (By similarity).  This cyanobacterium does not encode bioA (which catalyzes the formation of the precursor for this reaction in the cannonical pathway), instead it encodes bioU, which replaces bioA and also performs the first half of the cannonical BioD reaction.  Thus in this organism BioD has a different substrate (By similarity).
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_SHEPC
Sequence: MAKEFSRTRRIAQQLQQELAQVLQRDMKDPRIGFVTVNDVDVSRDLSYAKVFVTFFEEDKAVVQEKLNALISAAPYIRTLVAGRMKLRVMPELRFVYDSSLVEGMRMSNLVSQVINQDKAKQQQFGSADEVLNEDEGATDDTDDTKGKD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_METS4
Sequence: MNQEVMNLFNQQAQPQSFDQIKISISSPEKILSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKYKGVICEKCGVEVTLARVRRDRMGHIELAAPVAHIWFLKSLPSRIGLLLDMALKDLERILYFESYVVIEPGLTPLKERQLLSEEEYLRAQEEYGEDSFTAMIGAEAIRRILQDLNLEKIAADLRQEIATTTSDLKPKKLLKRLKIIEAFQLSGNKPEWMILTVVPVIPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLIELRAPDIIIRNEKRMLQEAVDALFDNGRRGRVITGANKRPLKSLADMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYARLDAKGFSATVKQAKKLVEKEKPEVWDILDEVIREHPVMLNRAPTLHRLGIQAFEPKLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQLEARVLMMSTNNILHPANGAPIIVPSQDIVLGLYYLSIVADGAPGEYKSNNPLNPMQGVYGDFGELEHALASRAVTLHSKVKWRWKGLGPDGEEVTRTYDTTPGRVILSSVLPRHPKVPFDVVNKLMTKKEISAMIDTVYRHCGQKESVIFCDRIMGLGFSHAFKAGISFGKDDMVVPENKWTIVDETRALVKDYEQQYQDGLITQGEKYNKVVDAWAKCSDRLASEMMNRISSVQKDEKGADKQVNSIYMMSHSGARGSPAQMKQLAAMRGLMAKPSGEIIESPIISNFKEGLDVLEYFNSTHGARKGLADTALKTANSGYLTRRLVDVAQDAVIREVDCGTDAGIRMRAIIDAGQVVATLATRILGRATAEDLVAQDGSIIVPKGQMIEERHLDAINKAGIQEVKIRSVLVCATKNGVCATCYGRDLARGTPVNQGEAVGVIAAQSIGEPGTQLTMRTFHIGGAAQIADSSFIESSFEGTVRIRNRGLARNSDGDLIAIGRNVAVVIVGPDGTERAVHRLQYGARVRVDEGDSIKRGQRIAEWDPYTRPILTEVDGIVAYEDLIDGQSITETTDESTGIAKRVVIDWRGSARTADLRPALAIHDQNGKVLKLPRGSDARALLPVEAIIGVDPGARVKAGDILARVSTESAKTRDITGGLPRVAELFEARRPKDAAIIAEKSGTISFGRDYKNKRRLSLTPHDGSEPVEYLIPKGKHIHLQDGDVVEVGDFIVDGNPAPHDILAIKGVEELAAYLVNEIQEVYRLQGVSINDKHIEVIVRQMLQKVEITDSGDSEILTGDQIDRTELQEINEQLVSEGKKPVQGVPVLLGITKASLQTRSFISAASFQETTRVLTEAAVNGKVDTLEGLKENVIVGSLIPAGTGAMIADIKSIARRRDELIMAQKTAESGAALQELPAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: DPH1_KLULA
Sequence: MTMGEVEKKPRRRFVGIKKAAEESDPSGSTTELVKKIKPKTNIRHAINQIPPELLNDEELNAAIKLLPSNYNFEIHKTVWNIRKHKAKRVAIQMPEGLLIYSLVISDILEQFCQCEIVVMGDVSYGACCIDDYTARSLDCDFIVHYAHSCLVPIDITTIKVLYIFVTINIDETHLIKTLQKNFPRGSRIAAFGTIQFNPTIHSMKDKLLQSEEHMLYIIPPQIKPLSKGEVLGCTSERLNKEQIDAMVYVGDGRFHLESAMIHNPEIPAFRYDPYNRRFTRERYDQKQLVEVRASAIDKARSSKKVGLILGALGRQGNLATVENLETKLKASGRTVVKIILSEIFPQKLAMFDDIDAFVQVACPRLSIDWGYAFNKPLLTPYETNVMLENDRMFNEKYYPMDYYHINGYGRGKVPNHDDVTI
What is the function of this protein?
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1, Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GACD_DICDI
Sequence: MSNPSKLSISPPNTFQHVGGSNLHVNKPPALQSPPRSPPLQHTTAQNNLAKSTSASNIAGIANQTTPSSSGSSSGSSSLNSIGSLTKSTSNSNLNINHYSSGNATMGASLQSTNTGNTITQSSSPPSSSSSTNNNNNVLPLPNKILHHPSPKKTTKSTIISGKLKRFFKSRPSRDSLYEKHILSAPFSSATLSFINIFKIITALKKTNAIETEGLFRVNGNAESVRSLWLMLNNVQEAIPVDGNSSAHDLAGLLKLYLRESKFPLVPLELFTSPAVPATIDEARVFVEEKLPTENVRVLSYLIEYLEQVSLKSSINKMNPIGLGVCFAPNILRSVNTNPSNPQFQVHMTNIQSHCNFITLLIENRLKIFKDSALSPVQGSNDDEILENLIIQSPDDELFDEQHQHEQELIDSSHEHHHSINNGDNNNNVDTSNVNGGSGDENNQSNVINDTALYDEFISLLTDESLGSSQKSVIIQRMTTLFQTDGDRFKSFLRDMQIDGIISLLEYILTLDEN
What is the function of this protein?
Rho GTPase-activating protein involved in the signal transduction pathway.
What are the official names of this protein?
Rho GTPase-activating protein gacD, GTPase activating factor for raC protein D.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR12_PANGI
Sequence: MPTIKQLIRNTRQPIRNVTKSPALRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNSQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSKYGVKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RUTB_AGRFC
Sequence: MTLPARPEPITLKPSETAVVVVDMQNAYSTEGGYVDLAGFDISGAKGTIANIKKTLDAARAAGVQVIYFQNGWDKDYVEAGGPGSPNWHKSNALKTMRKRPELQGQLLAKGTWDYAIVDELQPQPGDILVPKTRYSGFFNTNMDSVLRARGIRNLVFVGIATNVCVESSLRDAFHLEYFGVMLEDATHHLGPDFIQQATVYNVEKFFGWVATVNDFCGVISQAAPVTD
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: RPOZ_VIBA3
Sequence: MARVTVQDAVEKVGNRFDLVLIAARRARQMQTGGKDSLVPEENDKPTVIALREIEEGLITKDVLDARERQEQQEQEAAELAAVSSIAHTR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: CASP1_PANVG
Sequence: MKESGEHGETSKAPLNRGVSKGLSVLDLILRFIAIIGTLASAIAMGTTNETLPFFTQFIRFKAQYSDLPTLTFFVVANSIVCAYLILSLPLSIVHIIRSRAKFSRLLLIFLDAVMLALVTAGASAAAAIVYLAHKGNVRANWLAICQQFDSFCERISGSLIGSFGAMVVLILLILLSAIALARR
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 1, PvCASP1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: AAC6C_SERMA
Sequence: MIVICDHDNLDAWLALRTALWPSGSPEDHRAEMREILASPHHTAFMARGLDGAFVAFAEVALRYDYVNGCESSPVAFLEGIYTAERARRQGWAARLIAQVQEWAKQQGCSELASDTDIANLDSQRLHAALGFAETERVVFYRKTLG
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, netilmicin, isepamicin and sisomicin.
What are the official names of this protein?
Aminoglycoside N(6')-acetyltransferase type 1, AAC(6')-Ic, Aminoglycoside resistance protein.
Protein: GLOE_GLAL2
Sequence: MDYIKQAESTQLSSLSLSRLEGNNAEESKRLLEACAQDGFFYLDLRDHKQLLVDYEALLEIIKQYFNEPLDQKMKDDRKSDTIGYEPVATSAGVLDGLPDYYESFKVSWNQLRDHVQELPTVVETNIEVFDRFAKYVHSILLMILSRLSQTMGRNNDNRFESYHRDSIATRTNLTFLKYPKQDTTEHGVGHNKHTDVGTLTFLLSGQRGLQRLTPEGWCHVEPRSGFAVVNVGDSLRFLSDCVLSSVIHRVLPVGAHQTEDRYTLAYFLRPEDDAVFKDINGNLVSARSWHDRKFDHFRASHNQQKNDTILMGGMEENQKFLQYKFQA
What is the function of this protein?
2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non-competitive inhibition of beta-1,3-glucan synthase (PubMed:27705900).  The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4 (PubMed:27494047).  The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain (PubMed:27494047).  The 10R,12S-dimethylmyristic acid is then transferred to the first thiolation domain of the nonribosomal peptide synthetase gloA/GLNRPS4 by the acyl-AMP ligase gloD/GLligase, followed by its acylation to L-ornithine to trigger elongation of the cyclic hexapeptide (PubMed:27494047).  L-ornithine, 4R-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2), 3S-hydroxyl-L-homotyrosine (generated by gloG/GLHtyB, gloH/GLHtyA, gloI/GLHtyC, gloJ/GLHtyD and hydroxylated at C-3 by the dioxygenase gloM/GLOXY1), 3R-hydroxyl-L-glutamine (generated from L-glutamine probably by the dioxygenase gloE/GLOXY3) and 3S-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2 to yield pneumocandin B0), or 3S-hydroxyl-4S-methyl-L-proline (generated from L-leucine by the dioxygenase gloC/GLOXY4 to yield pneumocandin A0) are sequentially added to the growing chain (PubMed:25270390, PubMed:25879325, PubMed:25527531).  The last C domain of gloA/GLNRPS4 is proposed to be responsible for cyclization by condensation to form the peptide bond between L-ornithine and 3S-hydroxyl-4S-methyl-L-proline (for pneumocandin A0) or 3S-hydroxyl-L-proline (for pneumocandin B0).  Finally, the subsequent C-4 hydroxylation of 3S-hydroxyl-L-homotyrosine and L-ornithine dihydroxylation at C-4 and C-5 are performed by the cytochrome P450 monooxygenases gloP/GLP450-1 and gloO/GLP450-2, respectively (PubMed:25879325).
What are the official names of this protein?
2-oxoglutarate-dependent dioxygenase gloE, Glutamine hydroxylase, Pneumocandin biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: ILVD_PROMA
Sequence: MKLRSSAITQGVQRSPNRAMLRAVGFEDDDFNKPIIGIANGYSTITPCNIGLNDLAKQAEKAIKDWDGMPQMFGTITVSDGISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGCDKNMPGAMLAMARMNIPGIFVYGGTIKPGKLNGEDLTVVSAFEAVGQLTSGKITKEKLIEVEKHCIPGAGSCGGMFTANTMSAAIEAMGLSLPHSSTMAAEDQEKIKSTQKSAEVLIKAIKENIRPLDLLTKQAFENAISVVMAVGGSTNAVLHLLAIAHSSGVELSLDEFEKIRQRVPVLCDLKPSGKYVTVDLHKAGGIPQVMKILLEAGLINENCRTIENKTIKEMLLDVPAEPPSDQDVIRPFDSPVYKKGHLAILKGNLATEGSVAKISGIKEPILTGPAKVFESEEDCLKAILTEQIHSGDVVVIRNEGPVGGPGMREMLAPTSAIVGQGLGEKVALITDGRFSGGTYGLVVGHVAPEAAVGGNIALIQDGDSITVDAIQKLIQVNIEEAELKRRRSLWVKPKPKYNSGVLGKYATLVSSSSKGAVTDQNC
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: E4PD_SALPA
Sequence: MTVRIAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRHEREQLFVGDDVIRILHERTLADLPWRELGVDVVLDCTGVYGNQEHGEAHIAAGAKKVLFSHPGSNDLDATVVFGVNQNQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTAIHSAMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLAAGITRIFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKASEVNQLLQKAAQGAFHGIVDYTESPLVSIDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMAAVDFRLDASASTKL
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAMA_MAGGM
Sequence: MSSKPSNMLDEVTLYTHYGLSVAKKLGANMVDAFRSAFSVNDDIRQVYYRDKGISHAKAGRYSEAVVMLEQVYDADAFDVEVALHLGIAYVKTGAVDRGTELLERSIADAPDNIKVATVLGLTYVQVQKYDLAVPLLVKVAEANPVNFNVRFRLGVALDNLGRFDEAIDSFKIALGLRPNEGKVHRAIAYSYEQMGSHEEALPHFKKANELDERSAV
What is the function of this protein?
Probably forms a large homooligomer on which other magnetosome subunits assemble.  Required for formation of functional magnetosomes from pre-existing vesicles.
What are the official names of this protein?
Magnetosome protein MamA, MM24.3.
What is the protein family that this protein belongs to?
Belongs to the magnetosome MamA family.
What are the subcellular locations of this protein?
Magnetosome membrane; Peripheral membrane protein. Note=Purified magnetosomes remain attached to each other (PubMed:11571158). Probably a peripheral membrane protein, it is solubilized by Tween 20 (PubMed:14766587). Forms oligomers that cover the surface of the magnetosome (By similarity).
Protein: RLMG_PSEA6
Sequence: MKTELTLLDHSYELLRYPAENQHVSWQAWDSADEYLMEYVAQNITDLNGLNIHIYNDDFGALGVWFATNNAPLWISDSFVAHKALALNLERNHLPIENVNVQNSLYKANQKADLVLIKVPKTLALLEQQLIDLQSSVTPETRIIAAGKANAIQKSTLALFEKHLGLTTTSLAKKKSRLIFCQYDGVKQSVSPYPTKWKTDNTQFIMSNLANVFSRQQLDIGARVLLAHLPDANHKCIVDLGCGNGVLGLHVLHKSPGAHVIFVDESFMAIASAKMNIEQNMPDKLDQCKFIVSNCLDECLSSGENEATVDIVLCNPPFHQQNTITDHIALQMFKDSKRILKHAGELRVVGNRHLDYPQTIKRLFGHYKVLASDRKFSILSAIKK
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1899_MYCTU
Sequence: MAAMRAHARRRHPHALMSRAAGLPRLSWFAGLTWFAGGSTGAGCAAHPALAGLTAGARCPAYAAISASTARPAATAGTTPATGASGSARPTDAAGMADLARPGVVATHAVRTLGTTGSRAIGLCPCQPLDCPRSPQATLNLGSMGRSLDGPQWRRARVRLCGRWWRRSNTTRGASPRPPSTCRGDNVSMIELEVHQADVTKLELDAITNAANTRLRHAGGVAAAIARAGGPELQRESTEKAPIGLGEAVETTAGDMPARYVIHAATMELGGPTSGEIITAATAATLRKADELGCRSLALVAFGTGVGGFPLDDAARLMVGAVRRHRPGSLQRVVFAVHGDAAERAFSAAIQAGEDTARR
What are the official names of this protein?
Uncharacterized protein Rv1899c.
Protein: Y961_GEOTN
Sequence: MFPKRQGIIVWLHSLKYGKQLRKFGNIHYISKRLKYAVLYCDMEQVDHVMKKLAALPFVKRVEPSYRPFLRLEFESKGEKEKDSPYPLG
What are the official names of this protein?
UPF0298 protein GTNG_0961.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.