PharMolix/UniProtQA huggingface dataset:
Protein: NUON_TRIL1
Sequence: MDINVAQLFQTINLNVIMPEVILSVLGMALLLVNVFVPSKSKGYLAWLSLIGIVGAGFAAVTGWGTTVSSFSDSVVLDNFAIFFKIIFLLAAGLAVLISDQYMSREECNHGELYPIILFTTVGMMLMAAATDLMTIFLGLELMSISLYVLAGFNRDSIKSNEAGMKYFLLGAFSTGFLLYGMALIYGVTGTTRVAKIASLVTQVGGASNTMLLIGMFLMLTGFLFKIAAAPFHMWTPDVYEGAPTPMTAFMSAGPKAAGFAAMLRLLLVAFPAMIADWSDLLWILAVLTMTVGNFTALRQDNIKRMLAYSSIAHAGYCLVGFASGTATGTSGILFYMLSYTFMNIGAFAVIVLVGKKGEPNGTVMDYAGLGHKRPLLALAMTVFMFSLAGMPPTAGFIGKFYLFSGAVQAGYIWLAIIGVLNSAASVYYYLRVIVYMYFKPGEEEFDWFNVTAPVALALVVSAAGSLIPGIIPSMILQFAQQAVKLI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPF_RICB8
Sequence: MSSKINFVKMHGLGNDFVIINKKDLTGTYDLSQLAKSMAKRHLGIGCDQFIIYEEQNDSYEMIIYNIDGSSAKLCGNATRCLAKLIYLDTGKKDITVVVGNKKLLCHVIDENNISVNVGGVSFNESWMPSRDKIWEFAERYMIDLKETICVDVGNPHLVIFSKLELQDQKIVGEKLQDKALFADGVNVNFAEVRDNKIYLSVWERGSGLTLACGSGACGSFAAGLKLGFIHSPCEVVFKHGSLIMKEENGNIIMQGPASLVAKGMYYCE
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_XYLFM
Sequence: MKKKYILAIDQGTTSSRAILFDHKGRITGMAQREFTQIFPQPGWVEHNPRDIMTSVYTTITELLNNTQIDVRAIAGIGITNQRETTVIWNRQTGQPIYNAIVWQSRQTKNICDQLTTAGYQDLVHAKTGLLMDAYFSGTKVKWILDHAENAHTQAARGELAFGTIDTWIIWNLTGGQVHVTDYSNASRTLMYDIHALRWDPDLLTMLDIPAAILPDVRSSSEIYGLTQTPYFHGEQIPIAGIAGDQQAALFGQACFEPGMAKNTYGTGCFMLMHTGKKAVESKNGLLTTIAWGLNGEIEYALEGSIFIAGSVVQWLRDGLRMFGKASDSQAYADRVSDNGGVYVVPAFVGLGAPYWRSDVRGAVFGLTRSTTKEHFVRAALESMAYQTRDVLSAMQADADIELKELRTDGAAITNDFMAQFQSDILAVPVLRSQIAETTALGAAYLAGLATGFWSSREEMTQHWAINRCFKPQMDKEQREHLYAGWKQAVAATLGFRVA
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: FOLD_FRASN
Sequence: MRLLDGRSMAADIGRSVVDDVERLATTGVTPTLAVVLPTADEAARSYVRVIERGAAKVGVGCAVHELTGDPDELTATVDRLAADPAVHGMIVQTPLPDGLTAADVGARIPVGKDVDGMNPLSLGRLALGLPAFAPATAAAVLEILNRAAVPLAGARACVIGRSSVVGKPAALLLLAEDATVTVCHSRTKDLATVAHDADIVVAAVGRPKMVGAGHVRPGAVVIDVGTNWTDAGLVGDVDADAVAPVAGALTPVPGGVGPVTTMLLLRNTVRAAGG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PSTB1_CHRSD
Sequence: MTRNENVEENLSVRVRDLNLWYGDHQALKDISIDIFANTVTALIGPSGCGKSTFLRCLNRMNDLINSVSIKGLVEMDGHDVNARGMDEVALRRRVGMVFQKPNPFPKSIYENVAYAPRMHDMVSRKADQDELVERALRDAGLWNEVKDKLHEPGTSLSGGQQQRLCIARAIAVRPDVILMDEPTSALDPISTATIEDLMDKLKKDFTIVTVTHNMQQAARVADYTAFFHLGEMIEYNATKQMFSNPHTKKAEDYITGRYG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: OR2T8_HUMAN
Sequence: MENGSYTSYFILLGLFNHTRAHQVLFMMVLSIVLTSLFGNSLMILLIHWDHRLHTPMYFLLSQLSLMDVMLVSTTVPKMAADYLTGSKAISRAGCGAQIFFLPTLGGGECFLLAAMAYDRYAAVCHPLRYPTLMSWQLCLRMNLSCWLLGAADGLLQAVATLSFPYCGAHEIDHFFCETPVLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLHMRSTEARKKAFATCSSHVAVVGLFYGAAIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVKNSEVKGALTRCMGRCVALSRE
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2T8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YIDC_PELUB
Sequence: MDTRNVIAAISLSAAVIILYSLFFQPDPATIKKNLAEQNKIENNEDTPSLDKNENFSKLSRADALKENDRIQFENGSVVGSISLKGAAIDDLTFKEYNIELNRNEKITLLSPRNVEDGYLIESGFVSTNKNIDIPDASTVWEVSGNNKLTNNNPVKLTWSNTQGITFEKHISLDDQFLFTVKEKIINSSDKSYNFYSYGQIIRNELPEISGFYILHEGFLSVLDDELIEEDYDDIQDKKFTQIAQDGFVAISDKFWVTSVIPPKGKEFKTTFDYKNKFRANYISTKGIEVKANSSIEEKIQIIVAAKRVNVIDGYAENLNINKFDLAIDWGFMYFITKPLFFVLDYFFKLLGNYGLAIIAVTICIRLAFFPLANFSFKSMGKMKLLAPEMARLKELHKDDKMKLQQAMMALYKKEKVNPMSGCLPILVQIPVFFALYKVLFVTIEMRHMPFYGWIHDLSDRDPTSLFNVFGLIPWDPPSFLLIGAWPIIMGITMWIQQKLNPTPPDPIQAKIFMFFPVFLTVILAPFPAGLVIYWSFNNIFTMIQQYIVQRKMTIKTT
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PIF1_NPVAC
Sequence: MHFAIILLFLLVIIAIVYTYVDLIDVHHEEVRYPITVFDNTRAPLIEPPSEIVIEGNAHECHKTLTPCFTHGDCDLCREGLANCQLFDEDTIVKMRGDDGQEHETLIRAGEAYCLALDRERARSCNPNTGVWLLAETETGFALLCNCLRPGLVTQLNMYEDCNVPVGCAPHGRIDNINSASIRCVCDDGYVSDYNADTETPYCRPRTVRDVMYDESFFPRAPCADGQVRLDHPALNDFYRRHFRLEDICVIDPCSVDPISGQRTSGRLFHQPTVNGVGINGCNCPADDGLLPVFNRHTADTGMVRQSDRTVANACLQPFNVHMLSLRHVDYKFFWGRSDHTEFADADMVFQANVNQLSHERYRAILYSLLESHPDVTEIVTVNMGVMKISVSYDTTLKNILLPSSVFRLFRFKESGTAQPVCFFPGVGRCITVNSDSCIRRHAGGQVWTAETFTNSWCVLSREGTHIKVWSRASRYPRGDAPAALRLRGFFLNNDRERNTIRAVTTGDMTQGQQIDALTQILETYPNYSV
What is the function of this protein?
Per os infectivity factor that mediates the specific binding of occluded virions (ODV) to the host midgut target cells.
What are the official names of this protein?
Per os infectivity factor 1, PIF1.
What are the subcellular locations of this protein?
Virion membrane.
Protein: EX7L_ECOK1
Sequence: MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQLKYEQLKAKLQAEGLFDLQYKKSLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPIVSAVGHETDVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSTHQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLERLQKRMSFALESQLKRAGQQQQRLTRQLVQQNPQSRIHRAQTRIQQLEYRLAETLRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTSAADGAVLKQVKQVKVGETLTTRLGDGVVISEVSAVTKTRKSRKKTSNP
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_SACEN
Sequence: MAKEQGRKLIAQNRRARHDWSVLDTYETGIVLTGTEVKSLRQGKASLVDGFATVDRGEVWLRNVHIPEYTEGTWTNHEPRRSRKLLLHKGEIIRLIGKIQESGLSLIPLSLYFSDGKAKVELALAKGKKAHDKRQDLAKKDAQREIERAMGRARKGKW
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: T1RA_ECOLX
Sequence: MAELNLSNLTEADIITKCVMPAILNAGWDNTTQIRQEVKLRDGKVIVRGKVAARRTVKSADIVLYHKPGIPLAVIEAKANKHEIGKGMQQGIEYARLLDVPFVFATNGDGFIFRDATAAEGECLEKQITLDDFPSPAELWQKFCLWKGYTQAQLPVITQDYYDDGSGKSPRYYQLQAINKTIEAVSNGQNRVLLVMATGTGKTYTAFQIIWRLWKSKNKKRILFLADRNILVDQTKNNDFQPFGTAMTKVSGRTIDPAYEIHLALYQAITGPEEDQKAFKQVAPDFFDLIVIDECHRGSASEDSAWREILDYFSSATQIGLTATPKETHEVSSTDYFGDPVYVYSLKEGIEDGFLAPYKVVRVDIDVDLQGWRPTKGQTDLNGEVIDDRIYNQKDFDRTMVIDERTELVARTITDYLKRTNPMDKTIVFCNDIDHAERMRRALVNLNPEQVKKNDKYVMKITGDDEIGKAQLDNFINPKKPYPVIATTSELMTTGVDAKTCKLVVLDQNIQSMTKFKQIIGRGTRIDERYGKLWFTILDFKKATELFADERFDGIPEKVMDTTPEDIADPESDFEEKLEEISEHDEEQVTGVDEPPAPPYQVTDTDDVGPLPEEDEKKIRKFHVNGVAVGVIAQRVQYYDADGKLVTESFKDYTRKTLLKEYASLDDFTRKWQDADRKEAIIHELEQQGIIWEVLAEEVGKDLDPFDMLCHVVYGQPPLTRKERAENVRKRNYFTKYSEAAQAVLDNLLDKYADAGVQEIESIQVLKLKPFDSMGTLPEIIKTGFGDRNGYNQALSELENEIYQLPPRSA
What is the function of this protein?
The subtype B restriction (R) subunit of a type I restriction enzyme that recognizes 5'-GAGN(7)GTCA-3' and cleaves a random distance away.  Subunit R is required for both nuclease and ATPase activities, but not for modification.  After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
What are the official names of this protein?
Type I restriction enzyme EcoAI endonuclease subunit, EcoAI, R protein.
What is the protein family that this protein belongs to?
Belongs to the HsdR family.
Protein: NADK_BORPA
Sequence: MYFPIVALIGRYQDTGLDAPLTALAQMLTQAGRRVLVEAETARNAGVSGYPVADWDEIGRTATLAVVMGGDGTVLGAARHLAPYGVPLIGINHGRLGFITDIPLQDAHDALGRVLEGNYQAEDRMLLQGGVWRGEQQMYSASAVNDVVLNRAGRGGMIEVRVELDGAFMYTQRADGLIIATPTGSTAYSLSANGPILHPGMNAMVLVPVAPQTLSNRPIVIPDSGVLNMTLTAMGRVEIGASVHFDMQTWSDLQPGDRITVQRAPHTIRFVHPEGYSFFSTLRRKLHWNLMPQATDNLE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_LEVBA
Sequence: MNFKEKDPALWGAIADEEQRQEETIELIASENIVSHAVRTAQGSVLTNKYAEGYPGKRYYGGTQYIDVVEQLAIDRAKKLFGAEYANVQPHSGSQANQAVYAAFLKPGDTILGMGLDAGGHLTHGAKVNFSGKLYNSYSYALNPETELLDYDMIRDLARKVKPQLIVAGASAYSRTIDWQAFRSIADEVGAYLMVDMAHIAGLVATGLHPSPVGIADVVTTTTHKTLRGPRGGLILSQAENAKKINSAVFPGTQGGPLEHVIAGKAAAFFEDSQPAFKEYAQQIITNAQAMADEFSQLPTVRVVSGGTDNHLMTLDLSQTALNGKQAQELLDSVLITTNKEAIPNETLSPFKTSGIRLGTPAITTRGFNADESREVARLIVKTLLNPEDEAVLTGVRQRVKELTSAHPLSQLD
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR16_LOTJA
Sequence: MVKLRLKRCGKKQRAVYRIVAIDVRSRREGRDLRKVGFYDPIKNQTYLNIPVILNFLEQGAQPTGTVQDISKKAGFFMDL
What are the official names of this protein?
30S ribosomal protein S16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MCTP_DROME
Sequence: MSRIQYVDQVDQVELDQQQQPGSSSTVSGSTPPLQISPHGSPSLQQSQRLGKHLSKSASELNGHDCHLSESPHISPKRAKSAVAQQLAGVSSGGVASGVGVLQKTHGFFNNLRHRWSRAKSKDRLGRKSPSDFLEESTDYAADYSSEGSSVTHSPRHRSTTIGGSPLAREFRATAKMAQVIQRFGGSMEGRIDEHPENGSAGCSPPELSTQQQLEALQANELRRKREAQLRQFVFFQLRVHLKSGSDLVAMDKNGLSDPYVKFKVGGRLLHKSRTIHRDLNPVWDEVFIVPIEDPFQPIIVKVFDYDWGLQDDFMGSAKLDLTQLELGKAEDIHLQLCDSSGNGGSGLGEILINLTLWPRSQEDKEMHFQRNSKLAESSKRLKSQIWSSVVTILLVKAKDLPLAEDGSKLNDTHFKFRLGNEKYKSKSSWTERWLEQFDLHLFDEDQNLEIALWNRNTLYGKAIIDLSVFQRENTHGIWKPLEDCPGEVHLMLTISGTTALETISDLKAFKEDPREAQLLRERYKFLRCLQNLRDVGHLTVKVFGATGLAAADIGGKSDPFCVLELGNARLQTQTEYKTLTPNWNKIFTFNVKDITQVLEITVFDEDRDHRVEFLGKLVIPLLRIKSGVKRWYTLKDKNLCVRAKGNSPQIQLELTVVWSEIRAVCRALQPKEEKLIQQEAKFKRQLFLRNVNRLKEIIMDILDAARYVQSCFEWESPVRSSIAFVFWIVACVYGDLETVPLVLLLIILKNWLVRLITGTTDAAAHYDYEYDEDDDDDKEKEEKKSIKERLQAIQEVSQTVQNTIGYLASLGESTINTFNFSVPELTWLAVVLLLGAILVLHFVPLRWLLLFWGLMKFSRRLLRPNTIPNNELLDFLSRVPDNEEINQYRELPPSAPTDQTRNNPKKKLKGS
What is the function of this protein?
Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity (PubMed:28485711).
What are the official names of this protein?
Multiple C2 and transmembrane domain-containing protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CA112_HUMAN
Sequence: MFLPHMNHLTLEQTFFSQVLPKTVKLFDDMMYELTSQARGLSSQNLEIQTTLRNILQTMVQLLGALTGCVQHICATQESIILENIQSLPSSVLHIIKSTFVHCKNSESVYSGCLHLVSDLLQALFKEAYSLQKQLMELLDMVCMDPLVDDNDDILNMVIVIHSLLDICSVISSMDHAFHANTWKFIIKQSLKHQSIIKSQLKHKDIITSLCEDILFSFHSCLQLAEQMTQSDAQDNADYRLFQKTLKLCRFFANSLLHYAKEFLPFLSDSCCTLHQLYLQIHSKFPPSLYATRISKAHQEEIAGAFLVTLDPLISQLLTFQPFMQVVLDSKLDLPCELQFPQCLLLVVVMDKLPSQPKEVQTLWCTDSQVSETTTRISLLKAVFYSFEQCSGELSLPVHLQGLKSKGKAEVAVTLYQHVCVHLCTFITSFHPSLFAELDAALLNAVLSANMITSLLAMDAWCFLARYGTAELCAHHVTIVAHLIKSCPGECYQLINLSILLKRLFFFMAPPHQLEFIQKFSPKEAENLPLWQHISFQALPPELREQTVHEVTTVGTAECRKWLSRSRTLGELESLNTVLSALLAVCNSAGEALDTGKQTAIIEVVSQLWAFLNIKQVADQPYVQQTFSLLLPLLGFFIQTLDPKLILQAVTLQTSLLKLELPDYVRLAMLDFVSSLGKLFIPEAIQDRILPNLSCMFALLLADRSWLLEQHTLEAFTQFAEGTNHEEIVPQCLSSEETKNKVVSFLEKTGFVDETEAAKVERVKQEKGIFWEPFANVTVEEAKRSSLQPYAKRARQEFPWEEEYRSALHTIAGALEATESLLQKGPAPAWLSMEMEALQERMDKLKRYIHTLG
What are the official names of this protein?
Uncharacterized protein C1orf112.
Protein: AROC_RUTMC
Sequence: MSGNTIGKLFTITTAGESHGEALIGIVDGCPPRLALTEADLQGDLDLRKPGTSCHTSQRHEEDLVKILSGTFEGKTTGTTIALIIQNTDQRSKDYGNIKDTFRPGHADYTYDQKYGFRDYRGGGRSSARETAMRVACGGIAKKYLKQVYGIEIKGYLSQLGPIKAENFDWFEVHNNPFFCPDASKVRTLEEYMDALRKSGDSVGARINITANNMPVGLGEPIFDRLEADIAHGMMSINAVKGVEIGAGFKAITQKGTEHRDAITLSGFKSNHAGGVLGGISSGQDILVSIALKPTSSLRLPIESIDKNGEPIEVVTKGRHDPCVGIRATPIAEAMLAITIMDHVMRHRAQNSNVASITPIIPASI
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PEX22_DEBHA
Sequence: MPQAQIRKTQRNPKLWIAALVAASIVTISYKVYSSYIAEENIEDKKTEGDGGVEEKLRIAKRYTKKSIALTLSHSVLSSQLPLNEILLNSENVTFILPPNLSMDDLVCNIGNADEVERYNLPKTLLNNYKLLHCSNIDGYFNILKNLKPDTLLVCSEDLGIANNVPRDLHRFVKEIINIDQNKDDIYKKLSSIFIK
What is the function of this protein?
Involved in peroxisome biogenesis.
What are the official names of this protein?
Peroxisome assembly protein 22, Peroxin-22.
What is the protein family that this protein belongs to?
Belongs to the peroxin-22 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: GEMI6_HUMAN
Sequence: MSEWMKKGPLEWQDYIYKEVRVTASEKNEYKGWVLTTDPVSANIVLVNFLEDGSMSVTGIMGHAVQTVETMNEGDHRVREKLMHLFTSGDCKAYSPEDLEERKNSLKKWLEKNHIPITEQGDAPRTLCVAGVLTIDPPYGPENCSSSNEIILSRVQDLIEGHLTASQ
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.
What are the official names of this protein?
Gem-associated protein 6, Gemin-6, SIP2.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Protein: YQ015_HUMAN
Sequence: MMRWNFSPEDLSSIFRNNSTLPKITVKNVDIEFTIPTAVTIEVEPSPVQQDNPPISSEQADFSLAQPDSPSLPLESPEESESSAQQEATAQTPNPPKEVEPSPVQQEFPAEPTEPAKEVEPSATQQEASGHPLKSTKEVNPPPKQEIPAQPSEPPEKVELSPVLQQAPTQLLEPLKKVECSPVQQAVPAQSSEPSIVVEPSPVQQIAHLCLQSSLRKWNPL
What are the official names of this protein?
Putative uncharacterized protein FLJ43944.
Protein: GLGX_SHIBS
Sequence: MTQLAIGKPAPLGAHYDGQGVNFTLFSAHAERVELCVFDANGQEHRYDLPGHSGDIWHGYLPDARPGLRYGYRVHGPWQPAEGHRFNPAKLLIDPCARQIDGEFKDNPLLHAGHNEPDYRDNAAIAPKCVVVVDHYDWEDDAPPRTPWDSTIIYEAHVKGLTYLHPEIPVEIRGTYKALGHPVMINYLKQLGITALELLPVAQFASEPRLQRMGLSNYWGYNPVAMFALHPAYACSPETALDEFRDAIKALHKAGIEVILDIVLNHSAELDLDGPLFSLRGIDNRSYYWIREDGDYHNWTGCGNTLNLSHPAVVDYASACLRYWVETCHVDGFRFDLAAVMGRTPEFRQDAPLFTAIQNCPVLSQVKLIAEPWDIAPGGYQVGNFPPLFAEWNDHFRDAARRFWLHYDLPLGAFAGRFAASSDVFKRNGRLPSAAINLVTAHDGFTLRDCVCFNHKHNEANGEENRDGTNNNYSNNHGKEGLGGSLDLVERRRDSIHALLTTLLLSQGTPMLLAGDEHGHSQHGNNNAYCQDNQLTWLDWSQASSGLTAFTAALIHLRKRIPALVENRWWEEGDGNVRWLNRYAQPLSTDEWQNGPKQLQILLSDRFLIAINATLEVTEIVLPAGEWHAIPPFAGEDNPVITAVWQGPAHGLCVFQR
What is the function of this protein?
Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.
What are the official names of this protein?
Glycogen debranching enzyme, Limit dextrin alpha-1,6-maltotetraose-hydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: HGS_BOVIN
Sequence: MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVSSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCFEQLNKKAEGKAASTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERMRQKSAYTAYPKAEPTPVASSAPPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPTAQPGEGHAIPANVETSLPETDPQAVTAAGAAFSEQYQNGESEESHAQFLKALQNAVTTFVNRMKSNHVRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTIQMRAQMPAFSLPYAQLQAMPAAGGVLYQPSGPASFAGTFSPAGSVEGSPMHTMYMSQPAPAASGPYPSMPAAAADPSMVSAYMYPAGAAGAQAAAQGPAGPTTSPAYSSYQPTPTQGYQTVASQAPQSLPAISQPPQSGTMGYMGSQSVSMGYQPYSMQNLMPTLPGQDAPLPPPQQPYISGQQPVYQQMAPSSGPPQQQPPVAQQPPAQGPPAQGSEAQLISFD
What is the function of this protein?
Involved in intracellular signal transduction mediated by cytokines and growth factors.  When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF.  Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin.  May concentrate ubiquitinated receptors within clathrin-coated regions.  Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex).  The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.  May contribute to the efficient recruitment of SMADs to the activin receptor complex.  Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity).
What are the official names of this protein?
Hepatocyte growth factor-regulated tyrosine kinase substrate.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein. Note=Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments.