PharMolix/UniProtQA huggingface dataset:
Protein: ETS2_BOVIN
Sequence: MNDFGIKNMDQVAPVASSYRGTLKRQAAFDTFDGSLLAVFPSLNEEQTLQEVPTGLDSISHDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWTEQQVCQWLLWATNEFSLVDVNLQRFGMTGQVLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKNEDQYEENSHLNSVPHWINSNSLGFGVEQAPYGMQTQSYPKGGLLDGLCPASSAPSTLGPEQDFQMFPKARLNTVSVNYCSVGQDFPAGSLNLLSSASGKPRDHDSAETGGDSFESSESLLQSWNSQSSLLDVQRVPSFESFEDDCSQSLGLSKPTMSFKDYIQDRSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED
What is the function of this protein?
Transcription factor activating transcription.  Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity).
What are the official names of this protein?
Protein C-ets-2.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ASC_DANRE
Sequence: MAESFKEHLQEAFEDLGADNLRKFKSKLGDRRQEPRVTKSAIEKLKDEIDLADLMVGVFTSKDAVSVTVEILRAIKCNAVADDLLRNTGQSESKGALSDESKCASSKAVSKVAFSKVNFIDEHWKELIDRVNNVDPILDILRQKKVITNEDYCTIRNKETPQKKMRELLTGPITCAGNKGKEVLYDALRESNKFLMDDLEDAE
What is the function of this protein?
Functions as key mediator in apoptosis and inflammation (PubMed:12464617, PubMed:30150286).  Promotes caspase-mediated apoptosis (PubMed:12464617).  Induces proteolytic processing of caspa and caspa-dependent apoptosis (PubMed:12464617).  Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines (PubMed:30150286).  Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death (By similarity).  The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions (PubMed:30150286).  Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization (By similarity).  Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome (By similarity).
What are the official names of this protein?
Apoptosis-associated speck-like protein containing a CARD, PYD and CARD domain-containing protein.
What are the subcellular locations of this protein?
Cytoplasm. Inflammasome. Note=Co- localizes with nlrp1, caspa and caspb in the cytoplasm (PubMed:30150286). Co-localizes with caspa and caspb independently at large cytoplasmic aggregates, known as specks (PubMed:12464617, PubMed:30150286, PubMed:29791979).
Protein: LSM6_COCIM
Sequence: MESRGAADSQDPSAFLSGITGASVTVKLNSGVVYKGELQSIDGYMNIALEKTQEFVNGKLRKSYGDVFVRGNNVLYISAD
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates.  Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6. U5 tri-snRNP, and free U6 snRNP).  It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm6.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HSP1_ISOMA
Sequence: MASYRNSRSRSRSRFRRRRGRRSRVRGRDARQGRSSRRRRRGKGRAHSGKKGRRSGSRRRKRNNENK
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: HTF_GROGR
Sequence: QVNFSPGWGT
What is the function of this protein?
Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).
What are the official names of this protein?
Hypertrehalosaemic factor, Adipokinetic hormone 1, GroGr-AKH-1, Hypertrehalosaemic neuropeptide.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: UGPC_PECAS
Sequence: MACLKLQAVTKSYDGKTQIIQPIDLDVADGEFVVMVGPSGCGKSTLLRMVAGLERTTSGDIYIDNQRVTDLEPKDRGIAMVFQNYALYPHMNVFDNMAYSLKIRGFGKTQIRERVEEAARILELMPLLQRKPRELSGGQRQRVAMGRAIVREPAVFLFDEPLSNLDAKLRVQMRLELQQLHQRLKTTSLYVTHDQVEAMTLAQRVIVMNKGIAEQIGAPSDIYRRPASLFVASFIGSPAMNLWAGRISDDGCRFDIGEDIALVLPEPKPQWRGKALTLGVRPEHIQLATRETGGIPLQISTLELLGADNLAHGKWGGQNVIARLSYEHCPAIGSTLWLHLPTSSWHLFDSQSGLRME
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
sn-glycerol-3-phosphate import ATP-binding protein UgpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: T2EB_MOUSE
Sequence: MDPSLLRDRELFKKRALSTPVVEKRAVPSESPSSSSSKKKKAKVEHGGSSGSKQNSDHNNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMTEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDNHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVSRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVASIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDITPGK
What is the function of this protein?
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH.  Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
What are the official names of this protein?
General transcription factor IIE subunit 2, Transcription initiation factor IIE subunit beta, TFIIE-beta.
What is the protein family that this protein belongs to?
Belongs to the TFIIE beta subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YGIB_ECOLC
Sequence: MKRTKSIRHASFRKNWSARHLTPVALAVATVFMLAGCEKSDETVSLYQNADDCSAANPGKSAECTTAYNNALKEAERTAPKYATREDCVAEFGEGQCQQAPAQAGMAPENQAQAQQSSGSFWMPLMAGYMMGRLMGGGAGFAQQPLFSSKNPASPAYGKYTDATGKNYGAAQPGRTMTVPKTAMAPKPATTTTVTRGGFGESVAKQSTLQRSATGTSSRSMGG
What are the official names of this protein?
UPF0441 protein YgiB.
What is the protein family that this protein belongs to?
Belongs to the UPF0441 family.
Protein: PRAFB_DICDI
Sequence: MSSSSSIKLQPWNDFIEWGRYSIPGSQNAITRMEDNLNFYSGNYIAIVAVVLLITLFTNMNLLVAILLLGAIGYYLFFVQKGDKNIGFAVLTPMIQMVILGVVSVIVIYKLSGLTLFYTTLVSLLFVLAHSALKMRNLKNKASNFVSGIKNDLKNELK
What is the function of this protein?
May act as a general Rab protein regulator.
What are the official names of this protein?
PRA1 family protein 2.
What is the protein family that this protein belongs to?
Belongs to the PRA1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: EFC4A_HUMAN
Sequence: MASPGKPGADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMFVGVASAQGANPCRTPEETFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRELEQQLHAQAAEHLEAQAQNSQLWRAHEALRTQLEGAQEQIRRLESEARGRQEQTQRDVVAVSRNMQKEKVSLLRQLELLRELNTRLRDDRDACEARRAGSSCRKALTTARLPGPTCCCCCCWARPPRRGSGHLPSAR
What is the function of this protein?
Plays a role in store-operated Ca(2+) entry (SOCE).
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 4A, Calcium release-activated calcium channel regulator 2B, CRAC channel regulator 2B, Calcium release-activated channel regulator 2B.
What is the protein family that this protein belongs to?
Belongs to the EFCAB4 family.
Protein: NUOH_ACIC1
Sequence: MTVTTLGHPLAPVFAAAPLSPPTHRDIWWLIIVKTLGVFAFLVLATLFMIWAERRVVARMQQRIGPNRVGPFGLLQSLADGLKLALKEDIVPTLADKAVFILAPVISATPAFLAFAVIPFGPTVSIAGHHTNLQLTDLPVAVLFVLAMSSLGVYGIVLAGWSSGSPYPLLGGVRSAAQVVSYEIAMGLSFVGVFLYSGSLSTSDIVAAQAHRWGILWAGVSFAVYAIAMVGETNRAPFDLPEGETEIVGGFHTEYTSLKFALFYLAEYINMVTVSALMTTLFLGGWRAPWPLSLWSQANVGWWPVLWFLIKLGIVLFVFIWLRGTLPRFRYDQFMQFGWKVLIPVNLTWILVEAAIRVVNVSNWRVWVIPFAIFLALVAVGTYVADLVRQRSEVGDGGPILGPALVPNPDSPYPIPPLPGQRPLVGVLEARTDDFPVGSAAEPRNGGDGDA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SPL18_ORYSJ
Sequence: MDWDLKMPVSWDLAELEHNAVPNMAAAASAAEPGIAAVAASRGAPGRPECSVDLKLGGLGEFGAADALKEPAAAAKAPVSSAAAAASVAKVPPSTSTLKRPRGGGGGGGGQCPSCAVDGCKADLSKHRDYHRRHKVCEPHSKTPVVVVSGREMRFCQQCSRFHLLGEFDEAKRSCRKRLDGHNRRRRKPQADSMSSGSFMTSQQGTRFASFTPPRPEPSWPGIIKSEETPYYSHHHHPHPVMTSRQPHFVGSPSSATTAAFSPKEGRRFPFLHEGDQISFGGGGGAAAAATLEISVCQTTVVAPPPPESSSSNKMFSSDGLTTATTTTTTAHHHHHHHQVLDSDCALSLLSSPANSSSVDVSRMVQPSPAAAAGAEHHHHHQIPMAQPLVPNLQQQFGGSSPWFASSPAAAAVAGGGFACPSMDSEQQQQQQLNAVLVPGSNENEMNYHGMFHVGGEGSSDGTSPSLPFSWQ
What is the function of this protein?
Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3' (By similarity).  May be involved in panicle development.
What are the official names of this protein?
Squamosa promoter-binding-like protein 18.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBS_SOLLC
Sequence: MAQTMLLTANAKVDLRSKESLVERLKPKPLSSLFLPSLPLRFSSSSTNASSSKFTSTTVALFKSKAKAPPKKVAPPKEKQKVEDGIFGTSGGIGFTKQNELFVGRVAMIGFAASLLGEAITGKGILAQLNLETGIPIYEAEPLLLFFILFNLLGAIGALGDRGKFVDDPTPPTGLEKAVIPPGKSFKSALGLSEGGPLFGFTKANELFVGRLAQLGIAFSIIGEIITGKGALAQLNFETGVPINEIEPLLLFNIAFFFFAAINPGTGKFITDEEED
What is the function of this protein?
Seems to be involved in non-photochemical quenching, a process maintains the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage.
What are the official names of this protein?
Photosystem II 22 kDa protein, chloroplastic, CP22.
What is the protein family that this protein belongs to?
Belongs to the ELIP/psbS family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NUBPL_HUMAN
Sequence: MGIWQRLLLFGGVSLRAGGGATAPLGGSRAMVCGRQLSGAGSETLKQRRTQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRLPSPSE
What is the function of this protein?
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I).  May deliver of one or more Fe-S clusters to complex I subunits.
What are the official names of this protein?
Iron-sulfur protein NUBPL, IND1 homolog, Nucleotide-binding protein-like, huInd1.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS15_METS3
Sequence: MARPEWVTYSDEEIEEMILKFNKEGKSTSEIGIILRDQYGIPSVKEVTGERITQILKRNDQAGKYPEDLMNLIKRAVNIRDHLAENPKDLHSKRGLTIIESRIRRLASYYVNEGALPEGWRYNPKEAALLVK
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: TCYP_BACCR
Sequence: MNTLLVGINVAVMLILVGVLYYMQRKHVSFNKRVFTALGVGILFGLILQFIYEPTSKVIIESNTWFGLIGNGYVKLLQMIVMPLILVSIISAFTKLQLTKNLGKISGLIIGILILTTGIAAAVGIAASAGFDVSATGLQQGDAESARLKLVEERFTSIEKTTIPDKLLELLPTNPFLDLTGARPTSTISVVIFAAFIGIAFIGVKRKYPEQAELFKKMLDAVYAIVMRMVTLILRLTPYGVLALMAKTVAGSDINAILKLGNFVLASYVALIVMFIIHLLLIALSGLNPIQYLKKVFPVLTFAFTSRSSAGAMPLNIEAQKEKLGISEGIANFAASFGVSIGQNGCAGIYPAMLAMMVAPTVGIDPLQPQFILTLIAVVAISSFGVAGVGGGATFAALIVLSTMNLPIGIVALVISVEPLIDMGRTALNVSGSMTAGLISSKWLGELDQDTYNQDDTKTGEIAS
What is the function of this protein?
Mediates uptake of L-cystine, the oxidized form of L-cysteine.
What are the official names of this protein?
L-cystine uptake protein TcyP, Transporter of cystine TcyP.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HSDR_STAAC
Sequence: MAYQSEYALENEMMNQLEQLGYERVTIRDNKQLLDNFRTILNERHADKLEGNPLTDKEFQRLLTMIDGKSIFESARILRDKLPLRRDDESEIYLSFLDTKSWCKNKFQVTNQVSVEDTYKARYDVTILINGLPLVQVELKRRGIDINEAFNQVKRYRKQNYTGLFRYIQMFIISNGVETRYFSNNDSELLKSHMFYWSDKQNNRINTLQSFAESFMRPCQLAKMISRYMIINETDRILMAMRPYQVYAVEALIQQATETGNNGYVWHTTGSGKTLTSFKASQILSQQDDIKKVIFLVDRKDLDSQTEEEFNKFAKGAVDKTFNTSQLVRQLNDKSLPLIVTTIQKMAKAIQGNAPLLEQYKTNKVVFIIDECHRSQFGDMHRLVKQHFKNAQYFGFTGTPRFPENSSQDGRTTADIFGRCLHTYLIRDAIHDGNVLGFSVDYINTFKNKALKAEDNSMVEAIDTEEVWLADKRVELVTRHIINNHDKYTRNRQYSSIFTVQSIHALIKYYETFKRLNKKLEQPLTIAGIFTFKPNEDDRDGEVPYHSREKLEIMISDYNKKFETNFSTDTTNEYFNHISKNVKKGVKDSKIDILIVVNMFLTGFDSKVLNTLYVDKNLMYHDLIQAYSRTNRVEKESKPFGKIVNYRDLKKETDDALRVFSQTNDTDTILMRSYEEYKKEFMDAYRELKMIVPTPHMVDDIQDEEELKRFVEAYRLLAKIILRLKAFDEFEFTIDEIGMDEQENEDYKSKYLAVYDQVKRATAEKNKVSILNDIDFEIEMMRNDTINVNYIMNILRQIDLEDKAEQRRNQEQIRRILDHADDPTLRLKRDLIREFIDNVVPSLNKDDDIDQEYVNFESIKKEAEFKGFAGERSIDEQALKTISNDYQYSGVVNPHHLKKMIGDLPLKEKRKARKAIESFVAETTEKYGV
What is the function of this protein?
The restriction (R) subunit of a type I restriction enzyme that recognizes an undetermined sequence and cleaves a random distance away.  Subunit R is required for both nuclease and ATPase activities, but not for modification.  After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
What are the official names of this protein?
Type I restriction enzyme SauCOLORF180P endonuclease subunit, R protein, SauCOLORF180P, Type-1 restriction enzyme R protein.
What is the protein family that this protein belongs to?
Belongs to the HsdR family.
Protein: HSP72_HUMAN
Sequence: MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGGGGSGASGGPTIEEVD
What is the function of this protein?
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes.  Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation.  This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones.  The affinity for polypeptides is regulated by its nucleotide bound state.  In the ATP-bound form, it has a low affinity for substrate proteins.  However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins.  It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).  Plays a role in spermatogenesis.  In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).
What are the official names of this protein?
Heat shock-related 70 kDa protein 2, Heat shock 70 kDa protein 2.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with SHCBP1L at spindle during the meiosis process.
Protein: HA1B_MOUSE
Sequence: MVPCTLLLLLAAALAPTQTRAGPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELIQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRWEPPPSTVSNMATVAVLVVLGAAIVTGAVVAFVMKMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA
What is the function of this protein?
Involved in the presentation of foreign antigens to the immune system.
What are the official names of this protein?
H-2 class I histocompatibility antigen, K-B alpha chain, H-2K(B).
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SOM2_PANTR
Sequence: MAAGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
What is the function of this protein?
Plays an important role in growth control.  Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1.  It stimulates both the differentiation and proliferation of myoblasts.  It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
What are the official names of this protein?
Growth hormone variant, GH-V, Growth hormone 2, Placenta-specific growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: C4AC1_DROME
Sequence: MWIALLGIPILLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNFTPASVFNFVRESTAKAKGQNYLWYFLYAPMYNVVRPEEAEEVFQSTKLITKNVVYELIRPFLGDGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAELELNQVIPPFTLNNICETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFFVYGDYRKHLQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDDISMFQFNKLVYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDRFLPENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQENIKVKLSKRVK
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 4ac1, CYPIVAC1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: TDGF1_MOUSE
Sequence: MGYFSSSVVLLVAISSAFEFGPVAGRDLAIRDNSIWDQKEPAVRDRSFQFVPSVGIQNSKSLNKTCCLNGGTCILGSFCACPPSFYGRNCEHDVRKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGCDGHVMDQDLKASRTPCQTPSVTTTFMLAGACLFLDMKV
What is the function of this protein?
GPI-anchored cell membrane protein involved in Nodal signaling.  Cell-associated Tdgf1 acts as a Nodal coreceptor in cis.  Shedding of Tdgf1 by Tmem8a modulates Nodal signaling by allowing soluble Tdgf1 to act as a Nodal coreceptor on other cells.  Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
What are the official names of this protein?
Teratocarcinoma-derived growth factor, Cripto growth factor, Epidermal growth factor-like Cripto protein.
What is the protein family that this protein belongs to?
Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Released from the cell membrane by GPI cleavage.
Protein: KITH_MESM1
Sequence: MYRKYSDGIIEVITGPMYSGKSEELIKRIKILQFANIKTLIVKQKFDTRFSHNEIVSRSGTKLNTIVASNVEEIKKVWNNTYKAIAIDEVQFFDKDIINYIDELASKGIRVIISGLDTDFARKPFGIMPELLAIADDVLKLKAVCFSCKNAGTHTFRITNDKDQKLLGDTESYQARCRKCHLEGEEQKIQMDNLKLNLSL
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
Protein: RBM24_XENTR
Sequence: MHTTQKDTTYTKIFVGGLPYHTTDSSLRKYFEVFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQIHPALIQRPFGIPAHYVYPHAFVQPGVVIPHVQQAAAASTSPYIDYTSAAYAQYSAAAAAAAAYDQYPYAASPATTGYVTTAGYGYAVPQPLTAAAPGTAAAAAAAFGQYQPQQLQADRMQ
What is the function of this protein?
Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation.  Plays a major role in pre-mRNA alternative splicing regulation.  Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation.  Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing.  Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes.  Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound.  Involved in myogenic differentiation by regulating myog levels.  Binds to a huge amount of mRNAs.  Required for embryonic heart development, sarcomer and M-band formation in striated muscles.
What are the official names of this protein?
RNA-binding protein 24, RNA-binding motif protein 24.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: XPT_ACIB5
Sequence: MHALEQKILTEGIVLSDQVLKVDAFLNHQIDPVLMQQIGKEFAARFKDAGITKIITIEASGIAPAIMAGLELGVPVIFARKYQSLTLKDDLYRAKVFSFTKQTESTIAISNKHINSSDKALVIDDFLANGQAALGLIDLIHQANAEVVGVGIVIEKSFQPGRDLLLEKGYRVESLARVQSLADGTVTFVKE
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.