PharMolix/UniProtQA huggingface dataset:
Protein: MDM34_PICST
Sequence: MSFKVNWKSLETDSLTSWTKDLLTSALNSGKSPNILASSISIKDLNFGKIAPNFEILEIGELGRDRFRGIFKINYEGDFHLTLHTNVQANPLNIYYSNSMEKEIDSQFVTPNFLLSNEQFALPLDLKLSDIKISGIGIIVFSKSKGLTLVFRNDPLDSIKVSSTFDTVQVLANFLQKQIETQIRDLFRETLPTLIHQFSLKYLSLDNNSDDLHAHFASSSRTHSSALDPDNEFNNFTYSSKNLQKNLQLFNTRETLDLHIPKFKGIIQRSHLEKFTQNYPSLLNSLYLNLHEIDMKSYNTYNNNTGSNGIPIDLLINDKNFNRTNRVLKEISDIQSNSFYKQSNNNKDTTVKPKRRRIKYSTRKKAASPTSTLINDDFHMASLHSSVASSMPMSMSSSLSDSEERPQLLAQPRPMRISPDFYQAFLKSTPEQCWYQCKRVGLGTNYFNFATSQPISTSPIKKDPARDFIKEKKSINYIDINKVNNKLKELSMDRSGKRKQRNYGSATYESENPIVAPPPPYSH
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: IGSF6_MOUSE
Sequence: MGPVSARRSRLRPEISLILFQVGMVGACTVYVLQPGYLEVDYGSDAVTMECNFSTVGCPPVPPKSLWFRCGTHQPEALCLDGCRNEADKFTVKETLDPDQVFLTVNRLSPNDSAIYICGIAFPNELSPSAKHVGKGTTLVVRERLFSKEVRSFLIVLLALLSVYITGVCVTFIVLFKSKSNGPRSRETKGSKKKSARRIFQEIAQELYHKRYVETSHLPEQEGTDENRKALPNPGRA
What are the official names of this protein?
Immunoglobulin superfamily member 6, IgSF6.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RECF_ECO81
Sequence: MSLTRLLIRDFRNIETADLALSPGFNFLVGANGSGKTSVLEAIYTLGHGRAFRSLQIGRVIRHEQEAFVLHGRLQGEERETAIGLTKDKQGDSKVRIDGTDGHKVAELAHLMPMQLITPEGFTLLNGGPKYRRAFLDWGCFHNEPGFFTAWSNLKRLLKQRNAALRQVTRYEQLRPWDKELIPLAEQISTWRAEYSAGIAADMADTCKQFLPEFSLTFSFQRGWEKETEYAEVLERNFERDRQLTYTAHGPHKADLRIRADGAPVEDTLSRGQLKLLMCALRLAQGEFLTRESGRRCLYLIDDFASELDDERRGLLASRLKATQSQVFVSAISAEHVIDMSDENSKMFTVEKGKITD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_CORJK
Sequence: MARKRRLTGEAALNAAYGKSDHAPLLEAWGVDLPDDLLRLALTHRSFANENGHLPNNERLEFLGDAVLGLAVAEQLYRQFPERAESDISKMRSGVVNMYALADVARRLGMGDYILLGRGEMLTGGKDKHSILADSVESMLGAIYLHHGFEVARATVLRLFAEKITEAPTTGLTMDWKTVLLEKLSDMKLPLPTYEVRGEGPEHDKTFYATVTIEDLVTHGEGHTKKVAEHAAAKQAVQKLNERA
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2A2C_MOUSE
Sequence: MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHKAKSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A type 2-C, H2A-clustered histone 20, H2a-613B.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CAPSD_MSVS
Sequence: MSTSKRKRGDDANWSKRVPKKKPSSAGLKRAGSKADRPSLQIQTLQHAGTTMITVPSGGVCDLINTYARGSDEGNRHTSETLTYKIAVDYHFVADAAACRYSNTGTGVMWLVYDTTPGGQAPTPQTIFAYPDTLKAWPATWKVSRELCHRFVVKRRWLFNMETDGRIGSDIPPSNTSWKPCKRNIYFHKFTSGLGVRTQWKNVTDGGVGAIQRGALYMVIAPGNGLTFTAHGQTRLYFKSVGNQ
What is the function of this protein?
Encapsidates the viral genome into characteristic twinned ('geminate') particles.  Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus.  Plays a role in protection of the genome from degradation, virus acquisition and transmission by insect vectors, infectivity, and systemic movement.  The CP of monopartite geminiviruses is absolutely essential for virus movement (By similarity).
What are the official names of this protein?
Capsid protein, Coat protein, CP.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=It is actively transported into the host cell nucleus. It may be exported out of the nucleus through a nuclear export signal for cell-to-cell movement and spread (By similarity).
Protein: P2C53_ARATH
Sequence: MEDRFSAITNLHGDHKQAIFGVYVGHGGVKAAEFAAKNLDKNIVEEVVDATFLKEEGFKGGSSCVTALVSEGSLVVSNAGDCRAVMSVGEMMNGKELKPREDMLIRFTLWRIQGSLVVPRGIGDAQLKKWVIAEPETKISRVEHDHEFLILASHGLWDKVSNQEAVDIARPFCLRTEKPLLLAACKKLVDLSASRGSFDDISVMLIPLRQFV
What are the official names of this protein?
Putative protein phosphatase 2C 53, AtPP2C53, Protein phosphatase AP2C5.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: NUOI_NITHX
Sequence: MSINATARALLLTEFVSAFFLTMRYFFQPKATINYPFEKNPISPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGLCQEACPVDAIVEGPNFEFATETREELYYDKAKLLANGDRWEREIAKAIELDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: IACX1_WHEAT
Sequence: MAFKHQLILSTAILLAVLAAASASFREQCVPGREITYESLNARREYAVRQTCGYYLSAERQKRRCCDELSKVPELCWCEVLRILMDRRVTKEGVVKGSLLQDMSRCKKLTREFIAGIVGRE
What are the official names of this protein?
Trypsin/alpha-amylase inhibitor CMX1/CMX3, ITRL-1/ITRL-3.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I6 (cereal trypsin/alpha-amylase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: COBT_ECOK1
Sequence: MQTLANLLNTIPAIDPAAMSRAQRHIDGLLKPVGSLGRLEALGVQLAGMPGLNGIPHVGKKAVLVMCADHGVWEEGVAISPKEVTAIQAENMTRGTTGVCVLAAQAGANVHVIDVGIDTAEPIPGLINMRVARGSGNIASAPAMSRRQAEKLLLDVICYTRELAKNGVTLFGVGELGMANTTPAAAIVSTITGRDPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVNVLAKVGGFDLVGMAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIALSHLGLEPFLNMDMRLGEGSGAALAMPIIEAACAIYNNMGELAASKIVLPGNTTSDLNS
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: GCSP_NEIG1
Sequence: MKLSELFNPNEFAARHLSFGDEAALLAAVGEKSMDEFVGNTLPQSIRMPSELDLPEALTEADALAKLKGIASKNVINKSYIGLGYYPTRVPNVILRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGFPVAGASLLDEATAAAEAMAMAHRVGKVKSERFFVDARVYPQTLDVMKTRAKYFGFELVVSDFAQADEGEYFGALFQYVGKDGDVQDLQDVIGRLKAKGTIVAVAADIMSLVLLKSPAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDEFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRREKATSNICTAQALLANLAGMYAVYHGPKGVKRIANRIHTLASVFADALVSDGLKVVHEVFFDTVTVDFGSKEKADQVFAAALESGYNLRSVNNTQVAAAFHETSVYEDLADLYRAFTGKDTFTFADDVKGRLNAELLRQDDILQHPVYNSYHTEHEMLRYLKKLEDRDLAMNRSMISLGSCTMKLNATAEMLPITWTEFSDIHPYAPEAQTAGYRELLADMENSLKAITGFDAISFQPNSGAQGEYSGMLAIRRYQEAQGEAHRNICLIPKSAHGTNPATAAMLGLKVVVVDTDEHGNVNIDDLKAKAEQHRDALSAIMITYPSTHGVYEEGIRDICRIIHENGGQVYMDGANLNAQIGIMQPAEVGADVLHMNLHKTFCIPHGGGGPGMGPIGLKAHLAPFAPGHTLTDTHSASAGQTSVAAAAFGSASILPITWMYLTMMGKQGMEQATRWALLNANYVAKRLSEDYPILYTGKNGRIAHECIVDLRPLKAESGITETDIAKRLMDYGFHAPTVSFPVAGTLMIEPTESESKAELDRFIAALKSIRREVQKVIDGEWPKDDNPLVNAPHTAADITGEWAHPYSREEAVFPLPFVREHKFWPFVNRVDDVYGDRNLVCSCPPMENYED
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: TRMN6_ECODH
Sequence: MSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTDDSVMIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQQTVRFDLIISNPPYYQQGVECSTPQREQARYTTTLDHPSLLTCAAECITEEGFFCVVLPEQIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYSEAYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM87B_HUMAN
Sequence: MVAACRSVAGLLPRRRRCFPARAPLLRVALCLLCWTPAAVRAVPELGLWLETVNDKSGPLIFRKTMFNSTDIKLSVKSFHCSGPVKFTIVWHLKYHTCHNEHSNLEELFQKHKLSVDEDFCHYLKNDNCWTTKNENLDCNSDSQVFPSLNNKELINIRNVSNQERSMDVVARTQKDGFHIFIVSIKTENTDASWNLNVSLSMIGPHGYISASDWPLMIFYMVMCIVYILYGILWLTWSACYWKDILRIQFWIAAVIFLGMLEKAVFYSEYQNISNTGLSTQGLLIFAELISAIKRTLARLLVIIVSLGYGIVKPRLGTVMHRVIGLGLLYLIFAAVEGVMRVIGGSNHLAVVLDDIILAVIDSIFVWFIFISLAQTMKTLRLRKNTVKFSLYRHFKNTLIFAVLASIVFMGWTTKTFRIAKCQSDWMERWVDDAFWSFLFSLILIVIMFLWRPSANNQRYAFMPLIDDSDDEIEEFMVTSENLTEGIKLRASKSVSNGTAKPATSENFDEDLKWVEENIPSSFTDVALPVLVDSDEEIMTRSEMAEKMFSSEKIM
What is the function of this protein?
May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).
What are the official names of this protein?
Transmembrane protein 87B.
What is the protein family that this protein belongs to?
Belongs to the LU7TM family. TMEM87 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: MDH_NOCFA
Sequence: MSTADRTAPVTVTVTGAAGQIAYGLLFRIASGAMLGPHTPIRLRLLEIPAAVASLEGVAMELEDGAFPLLDAIDISDDPWTGFAGANVALLVGARPRTAGMERADLLAANGPIFTDQGQAINAVAADDVKVLVVGNPANTNAFIAMSNAPDVPAERFTAMTRLDHNRAIAQLAKKTGAPATEIHRIAVWGNHSATQYPDLTHATVAGRPARELVDEQWLREDFIPTVQQRGTAIIQARGASSAASAASAAIDHIHDWVLGTPAGEWTSMAVPSDGSYGVPDGLISSFPVTCADGAYRIVEGLEVDAFSRERIDASVAELTAEREAVVELGFAKG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: DGGGP_PYRFU
Sequence: MEVKGFIEIMRPHNCILAGIVGILGALVAYEGIPDIKTLTLIFWVVYFGCSGGNTANDYFDYEIDKINRPNRPLPRGAMSRRAALYYALLQYAIGSILAYFLNIRAFVFATIAYFLTFLYGWKLKPLPLVGNITVAALTAATPIYGAIGVGRIGLAGYLAICAFLVNVSREIMKDIEDIEGDKALGARTLPIIIGEKKAAIIAAIFGFLTVIASFLPVKVGIGLGYAPIIIVDIIIIKASIDVLRDPKAASKGQKLLKIATFVAVISFLAGALTKGV
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP).  This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Digeranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, Geranylgeranylglycerol-phosphate geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PALA_KLULA
Sequence: MNDIFAIPFKRALQINLKDAFTVVINNTFYQTAASVEADLTQLDKYRDVLFHLDVCQADLNMLKQYYMALKAIAVKLPDDQVEFTWFNTLGLKSSGMTRNSLRFETFNVLYNIGAMYSSLAVEQRLESTEGLKESCRLFKLSAGCFKFIYEHEVSNNFKFFDEYTLNALVSMMLAQAQQMVWKKACFDDIERHSILSRLALQVALFYQTASKNSNCSPYIRTDWVKSLTSKSHYFMAIAYYRSGLHQVQKQNYAQGICDFQYALTWINKLSLDDELTEWRGEVQALLESAERDNDLIYLQASVQNPSKVKPVMMVQADLFDEIEKKDGNIFKNLLPIDVLESCNAFNERVETYVKEHISNPLESMNKLLISNTPQYMDFKSYYISEQEWNSYSDSLQDLEQLRAYVAGELKLSESILQKDIQENEQMIREHGLLRWKIPSKDKKIESLLADLTNIRNYIENGMKVDTETASLFKTLDHDLVTNVSQPPESSDPIMKEASLILQGRKNHILAAERKIIENRLLPKIVSYYKKTGSKDFEPVFQEHIRMFDGDLLQVQKEKAKNKEMLTKVTLSSPEQVQISRNDPRTLYLEELKHSSNVLSELKENIISGKQFYQDLITALESKLKEIEDYVNERKLQRTELNDTLLCDTNES
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.  May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity).
What are the official names of this protein?
pH-response regulator protein palA/RIM20.
What is the protein family that this protein belongs to?
Belongs to the palA/RIM20 family.
Protein: BIOF_POLNA
Sequence: MLIDYLNHQLREREAQGLTRQRRIAESPCAPRQRVSQRGQPARDLLAFCSNDYLGLANHPALVRALAEGAQLYGAGSGASHLISGHSEAHAALEADLAAWLAPCIPNAQALYFCTGYMANLALLTALGGANATIFADKLNHASLVDGALLAKATLQRYAHKSLAVLARQLAACDTPIKLIVTDAVFSMDGDVADLPELLALAERFDAWLVVDDAHGFGVLGEEGRGSLSHFGLCSERLICMGTLGKAAGVGGAFVAAHPSIIDWLVQTARPYIYTTAAPPAVAHALRESLRLIGGTEGDQRRKQLQQLISQLRSQLAELIAAQPALGWHLADSSTAIQPLIVGSNEAALALAAALDAQGLWVPAIRPPTVPAGTARLRITLSASHSADDVRQLVDALAQAGKDLAGAQP
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: SYI_CAMFF
Sequence: MDYKDTLLLPTTDFAMRGNLPECEPARYAKWDEQKVYEKMKAKREKSAISFNIHDGPPYANGHLHIGHALNKILKDIILKTHYFFGQGIRYTPGWDCHGLPIEQQVEVKLGDKKKSMSKSDIRQECRNWAKEFITVQKDEFKSLGVIGDWNDPYLTMKFKFEANIYRTLCEVAKKGLLVERSKPVFWSWAARSALAEAEVEYEDKEDYSLYVAFCLSDAACKKLGVSDAKAVIWTTTPWTLVANQAISLNPNEKYALTSEGYIIALPLKETLINQGIINGKILKEFASSELEGLSAINPLNGRDSRFILGEHVLMDGGTGLVHTAPGHGEDDYFASLKYGIEVIMPVDEAGLYDETLRVKKLLPEHLLNEFIGLHIFKANEKLIELLGDAAVKVSKFVHSYPFCWRTHKPVIYRATKQWFIAMDEPKLSGKTLRQTALEALKSVKFYPEVGVKRISSMIENRPDWCISRQRDWGVPIAFFRDSATKEPIFDSRVLEHVAKVFDEKGSDAWWNLEISELLPKGTNLDPSKLEKVTDILDVWFDSGSTWNAVLNSGDYDAGGYQADMYLEGSDQHRGWFQSSLLLSCAINQKAPYKSVLTHGFTVDGNGNKMSKSKGNVIAPSDVAKRYGVEILRLWVGLSDYSSDLKISDDILKQVAEQYRKIRNTIRFLLANINDLDDISSHFGTLDKWILARATKSFKEVSECFKNYEYSKGFNILLNFLSTDLSGIYLDICKDRLYCDEKDGLRRRSSQSAMAIIAKSLLSLIAPTLTYTVDEAIEFAPDIIKNGAKDAFDLVYEPLVFEFKIDDELLTSSREKFNEIIDVLKKDKIIKSTLEVILETSSNEILANDLDEIIDWYMVSFVRNIESDEFLAEFAVGNDKFKIVKADRYKCPRCWKYAAKIDNDLCPRCAKVLKRV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTMCB_GEOSE
Sequence: MTHTSENQAGFRVKIQRFGSYLSGMIMPNIGAFIAWGIITALFIPTGWLPNETFAKLVGPMITYLLPLLIGYTGGKMIYDVRGGVVGATATMGVIVGSDIPMFLGAMIMGPLGGYLIKKFDQQIQGKVKQGFEMLVNNFSAGIIGGLLTLAAFKGVGPVVSAISKTLAAGVEKIVDLHLLPLANIFIEPGKVLFLNNAINHGILSPLGIEQAAKTGKSILFLLEPNPGPGLGILLAYWLFGKGMAKQSAPGAIIIHFLGGIHEIYFPYVLMRPILILAAIAGGVSGVLTFTIFDAGLVAVPSPGSIFALLAMTPKGNYLGVLAGVLVATAVSFFVASIFLKSAKNNEEDITKATEKMQQLKGKKSDVVAVLKNEEKVIPAKVKKIVFACDAGMGSSAMGASILRNKMQKAGLNIEVTNTAINQLPEDADIVITHQNLTDRAKEKLPKAFHISVENFLNSPKYDELIEMLKK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II CmtAB PTS system is involved in D-mannitol transport.
What are the official names of this protein?
PTS system mannitol-specific EIICB component, EIICB-Mtl, EII-Mtl.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LIP1_CANGA
Sequence: MSTPYTPAPQIFNLFKVLAVSLALIAAVEYFKYGTRINYEWFHCTPVMERVGGPDSSVLKIWARGGPSCDKRGEYKTILKRISRDYEPNDEHLSFCIKENMSVDPVHYPIHEDKGEPGYIAYVGYDSDKRTVDELCEGTTVFHF
What is the function of this protein?
Component of the ceramide synthase complex required for synthesis of ceramides.
What are the official names of this protein?
Ceramide synthase subunit LIP1.
What is the protein family that this protein belongs to?
Belongs to the LIP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: 36010_ASFM2
Sequence: MFPSLQSFAKKVLARHHVSIDYHYILKHCGLWWYKAPISLDCKHMLIKLPSFADGLDLNTALMLATKENNYQLIKLFTEWGADINYGLICANTPPVREFCWELGAKYQVDKNKVMHMFFKLIHHGTTSSNIILCLKLFNNNPFPTYVIIREIKSSIYWKLRRLVEDTDILSNMSDDDMLTIYCFILALQDNLREAISYFYQHFKHLNTWWLICALCFNKLFDLHDLYEKEKIRMDMDEMMCIACTKDNNFLTIYYCFLLGANINQAMLACVQFYNMDNLFFCIDLGADAFEEAKALADQRNYFLMYHRLSIDIYSPDSSLLTLKEADPKKIYHLLKNYKSKNMMVYFDYDGHDTV
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-10L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: RS10_STAA9
Sequence: MAKQKIRIRLKAYDHRVIDQSAEKIVETAKRSGADVSGPIPLPTEKSVYTIIRAVHKYKDSREQFEQRTHKRLIDIVNPTPKTVDALMGLNLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: LRC26_MOUSE
Sequence: MRGSFFSRLPPQLSLLLLLSLRRVWTQEDIGTAPSKSPVAPECPEACSCSLGGKANCSALALPAVPADLSWQVRSLLLDHNRVSALPPGAFANAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLSLAGNRLALLEPSILGPLPLLRVLSLQDNSLSAIEAGLLNNLPALDVLRLHGNPWTCNCALRPLCTWLRKHPRPASETETLLCVSPRLQTLSLLTAFPDAAFKQCTQSLAARDLAVVYALGPVSFLASLAICLALGSVLTACGARRRRRRRTTVRHLLRRQLDPEGPPSLEDAGSPVTAAIQA
What is the function of this protein?
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha).  Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells.  These are characterized by negative membrane voltages and constant low levels of calcium (By similarity).
What are the official names of this protein?
Leucine-rich repeat-containing protein 26, BK channel auxiliary gamma subunit LRRC26.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels.
Protein: RISB_METLZ
Sequence: MKVYEGNLVSKNIKIGIVAARFNEFIVSKLLGGALDALKRHDVADDDVEIAWVPGAFEIPLIAEKMAESKKYDAVICLGAVIRGSTSHYDYVCNEVTKGIATVSLKSGIPVMFGVLTTDNLEQAIERAGSKVGNKGFDAAVGAIEMVNVIRQLGN
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: S35A1_HUMAN
Sequence: MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSVGILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFALGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV
What is the function of this protein?
Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP (PubMed:15576474, PubMed:12682060, PubMed:23873973).  Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity).  Also able to exchange CMP-sialic acid for AMP and UMP (PubMed:12682060).  Also mediates the transport of CDP-ribitol (By similarity).
What are the official names of this protein?
CMP-sialic acid transporter, CMP-SA-Tr, CMP-Sia-Tr, CST, Solute carrier family 35 member A1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: HIS6_LEPIR
Sequence: MLKPRIIPTLLVQHGGLVKTIKFSNQRYIGDPLNAVRIFNEKEADELTVLDISASREGKAPDYRLIERLANECRMPLSYGGGIKNLEQASRILSFGVEKIIVSSLAIENPKVISSMATYLGNQSVVVAIDFKKTLLTRRYEVFIHNGTKKTGISPEDLLKHAIEFGAGEILLNSIDRDGVMEGYDLEMLKKFRSICTVPMTVLGGAGSLQDLKSLIQNLGIVGVSAGSLFVYKGIHKAVLINYPNREDKEALFY
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
What are the official names of this protein?
Putative imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.