PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_NEIM0
Sequence: MLQTDNLTAAQPQRIVAAQTASAQEELLERALRPKTLDDYIGQDKAKEQLAIFIQAAKKRGEALDHVLLFGPPGLGKTTLAHIIAKELGVNLRQTSGPVLERAGDLAALLTNLDPHDVLFIDEIHRLSPVVEEILYPALEDYRLDIMIGEGPAARSVKIDLPPFTLIGATTRAGMLTNPLRDRFGIVSRLEFYENRDLTTIVSRSAQLLQLDMSEEGAEEIAKRSRGTPRIANRLLRRVRDFADVKNNGTIDGGIADAALSMLDVDAQGLDVMDRKFLEAVLHKFGGGPVGLDNVAAAIGESTDTIEDVIEPYLIQQGFLQRTPRGRMATERAYLHFGLPVEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: OOEP_FELCA
Sequence: MADDAGATEAQGDQCTPAQSLGRLLKLPLPPPRIRTRPWWFPVQELRDPLVFYLEAWLADSIFGPDRAIIPEIEWMSQVLLTVDIVNSGDLVEITIFGRPRVQNRVKSVLLSLANWHRKHRARAEKMNQLEEFLKTHASGPQTPEHRIV
What is the function of this protein?
As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity).  Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity).  Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity).  As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity).  Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).
What are the official names of this protein?
Oocyte-expressed protein homolog, Oocyte- and embryo-specific protein 19, cOEP19.
What is the protein family that this protein belongs to?
Belongs to the KHDC1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VATD_HUMAN
Sequence: MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891).
What are the official names of this protein?
V-type proton ATPase subunit D, V-ATPase subunit D, V-ATPase 28 kDa accessory protein, Vacuolar proton pump subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Note=Localizes to centrosome and the base of the cilium.
Protein: SYFB_LATSS
Sequence: MKVSYNWLKDYLDLTTAPEALAEKITRTGIEVADVAQMSAGLKKIVVGHVLSCEPHPDSDHLHVCEVDVGEEEPFQIVCGAPNVAAGQYVIVALPNSRIADNVKIKKGKMRGVVSMGMICGLQEIGFADSVVPKEYVDGIFVFPEAIAPGTDVYEALGMTDYIIDLDLTANRADALGIHGVAHEVAAIESLTPHFEDVAVSESDVQTKNQLSAQVADEQLAPTYHLRMLQNVTVQPSPLWLQTRLWNAGIRPINNLVDVTNYMMLTYGQPLHAFDADTLTGDHKQIEVRLAKTGEKLTTLDEAEHDLTNEDIVITDGNQPIALAGVMGGFNSEITANTKNVIIEAAIFAPTAVRKTAQRHNLRSDASSRFEKGVNVADVQVALDAAAAMMAELGAGQVTAGVVSPTNLAPQPKVIQFDSARVNRVLGTDMSVQTMINLLERLGFEVANNADQLTVTIPARRWDIEIQADVIEEIARLYGYDNLPSTLPTGDMTTGALTTEQKALRRTRHTLEGAGLTQAISYALTTEEKAGQFTLAAKQTATVLDWPMTQDHAYLRMNLVTGLLDDAAYNVARKQTDLALYEQGRVFLQHADQARPNEVEYVAGLMSGNRQVKSWQEAAAPVDFYTIKGIVDTLMASYNLQAAVAYQATDAYPEMHPGRTAAIYVGETFVGIVGQIHPKIAKATHLKETYIFELDLAKILELQRQTIIAKPAPKFPEVTRDIALQVPEAITNADLVNAIKEKGGRYLVSVSLFDVYAGSHIEAGEKSMAYTLTYLNEDATLTEEEVNAAFEKVVAHLVATFQAKVR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAF1B_CHICK
Sequence: MKVITCEIAWHNKEPVYSLDFQHGTDGKINRLASAGVDTAVRVWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPSGEVLASGGDDAVILLWKLNDSKELEPLAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWTSDGNYMASASVDNTAIMWDVVKGQKVSILNEHKSYVQGITWDPLGQYIATLSCDRVLRVYNTQTKRVAFNVTKMPSESGAEGEARSYRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCVESGENVTNTTYVFSRNNLKRPMGHLPCPGKATLAVRCCPVYFELRQALNKGEVSQKSSPALLNLPYRLVFAVASEDSVLFYDTEQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGYCSFVTFEKDELGIPLKEKPQIHVRTSVVTEKKVKKSQPNKVISPGSRLTEGTSLSTPTLQPKTPVAAAKDLPSTPVGIKNVPVSSSEERKISQPASQSTKVNQPRRITLNTLQAWSKTPRRVNLIPLKPDTPASVYTDTVPVPPSSEQEHERPLPSGDSLQNPPASKRPRTEEMPLSVSAEDQIGCKPNK
What is the function of this protein?
Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair.  Assembles histone octamers onto replicating DNA in vitro.  CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
What are the official names of this protein?
Chromatin assembly factor 1 subunit B, CAF-1 subunit B, Chromatin assembly factor I p60 subunit, CAF-I 60 kDa subunit, CAF-I p60.
What is the protein family that this protein belongs to?
Belongs to the WD repeat HIR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ASTD_PSESM
Sequence: MSTLYIAGAWQAGQGELFHSLNPVTLHVLWSGQGATAEQVDHAVQAARQAFPAWALLSLDQRIAVLDAFAVSLKAHADELANCIGEETGKPLWESATEVTSMVNKIAISVQSYRERTGEKSAPLGDATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVLFKPSELTPKVAELTVKCWIEAGLPAGVLNLLQGGRETGIALAANPGIDGLFFTGSSRTGNALHQQFAGRPDKILALEMGGNNPLVVDQVQDIDAAVYTIIQSAFISAGQRCTCARRLLVPEGDWGDALLARLVAVSATLDVGAFDQQPAPFMGSVISLEAARALLDAQRHLLANGAVTLLEMRQPQPGAALLTPGIVDVSAVANRPDVELFGPLLQVVRYAGFDAAIAEANATQYGLAAGLLSDSEARYQQFWLQSRAGIVNWNKQLTGAASSAPFGGVGASGNHRASAYYAADYCAYPVASLETGSLTLPATLTPGVRLS
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: AK1C1_MACFU
Sequence: MDSKHQCVKLNDGHFMPVLGFGTYAPAEVPKNKAIEATKLAIEAGFRHIDSAHLYNNEEYVGLAIRSKIADGTVKREDIFYTSKLWCNSHRPEFVRPALERSLKNLQLDYVDLYLIHFPVSLKPGEELIPKDENGKLLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQRKLLDFCKSKDIVLVAYSALGSHREKPWVDQNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENMKVFEFQLTSEDMKAIDGLDRNIRYLTLDIFAGPPNYPFSDEY
What is the function of this protein?
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids.  Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH.  Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens.  May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate.  Displays affinity for bile acids.
What are the official names of this protein?
Aldo-keto reductase family 1 member C1, 20-alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, Dihydrodiol dehydrogenase 1, DD-1, DD1.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RBPA_SYNY3
Sequence: MSIYVGNLSYDVSEADLTAVFAEYGSVKRVQLPTDRETGRMRGFGFVELEADAEETAAIEALDGAEWMGRDLKVNKAKPRENRSGGGSFGGGRKSYGGSRY
What are the official names of this protein?
Putative RNA-binding protein RbpA.
Protein: MYB25_ARATH
Sequence: MNGEISRPPELISSRNPCKSFENAIHKAVEAELAELAKSDANGGGKSKVKGPWLPEQDEALTRLVKMCGPRNWNLISRGIPGRSGKSCRLRWCNQLDPILKRKPFSDEEEHMIMSAQAVLGNKWSVIAKLLPGRTDNAIKNHWNSNLRRKPAEQWKIPLLMSNTEIVYQLYPSMVRRISNASPKEHLPQEEETGVLSDDKMDDEAKEPPREQNSKTGVYRPVARMGAFSVCKPGYMAPCEGPLVQASRPDSLAGKFLQSLCYDPIIPSKCGHGCCNHQDSTTLSSSSVLGSEFVDYEEHSSAELDKELISISNDLNNTAWIRSGKEAEQSLKADDQFRREYAHSKFSGMVNNGVSSQMVRQDLRALS
What is the function of this protein?
Required for male gametophyte (pollen) development.
What are the official names of this protein?
Transcription factor MYB25, Myb-related protein 25, AtMYB25.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEPA_BARHE
Sequence: MTVDRNYIRNFSIVAHIDHGKSTLADRLIQMTGGLETREMKEQVLDSMDIERERGITIKAQTVRLHYKAKNGETYILNLIDTPGHVDFAYEVSRSLAACEGSLLVVDASQGVEAQTLANVYQAIDNSHELVVVLNKVDLPAAEPERVKEQIEDVIGIDTSEAVEISAKTGLGVSDVLEAIVTQLPSPRTGDVNKPLKAMLVDSWYDAYLGVIVLVRVIDGILKKGQIIRMMGTGAKYPVERVGVFTPKMIQVDELGPGEIGFITASIKEVADTRVGDTITEERCPCEEALPGFKPAQPVVFCGLFPIDAADFDDLRAAMGKLRLNDASFSFEVETSAALGFGFRCGFLGLLHLEIIQERLEREFNLDLIATAPSVVYRMNMHDGSVKELHNPADMPDIVKISSIEEPWIRATIMTPDNYLGSVLELCQERRGIQVSLSYVGTRAMVTYDLPLNEVVFDFYDRLKSISKGYASFDYQMRDYTEGDLVKMSILVNGESIDALSMLVHRTIAEKRGRSLCEKLKDLIPQHMFQIPIQAAIGGKIIARETIRALRKDVTAKCYGGDVTRKRKLLEKQKEGKKRMRQFGKVEIPQSAFIQALKMNK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RK32_MORIN
Sequence: MAVPKKRTSISKKRIRKNIWKKKGYWAALKAFSLGKSLSTRNSKSFFYPTNK
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL14_STAAR
Sequence: MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVKNATPGGVVKKGDVVKAVIVRTKSGVRRNDGSYIKFDENACVIIRDDKGPRGTRIFGPVARELREGNFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ENGB_MALP2
Sequence: MPSFIKSCFSSNDWITDDKKEICFIGRSNVGKSSLINALANAKIAKTSNTPGRTQLANFYDFDKFRLIDLPGYGYAKVSKSKHFELSKIISEYIYLRKNLVAVFQIIDISVITDLDLQMSELLSNRFNQHYIVLNKADKEAKSYFDNNFAKIAAKLKKDKENIVCVSAKNKTNIPNLKKLIGSVIL
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: RS20_MESH7
Sequence: MANIKSKIKSITKMQKARARNNAIKSRVKTAIKKAKIAISTDASNKSDLIAKAHSEISKAKSKGVFHKNKANRKISRLNLFANTYTTPAQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: DLTC_STAA8
Sequence: MEFREQVLNLLAEVAENDIVKENPDVEIFEEGIIDSFQTVGLLLEIQNKLDIEVSIMDFDRDEWATPNKIVEALEELR
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_LATSS
Sequence: MAKKVANIVKLQIPAGKATPAPPVGPALGQAGINIMGFTKDFNARTADQAGLLIPVVITVYEDRSFDFVTKTPPAAVLLKKAAGVQKGSGEPNTKKVATVTKAQVQEIAETKMQDLNAADVEAAMRMVEGTARSMGFTVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: P30_ASFP4
Sequence: MKMEVIFKTDLRSSSQVVFHAGSLYNWFSVEIINSGRIVTTAIKTLLSTVKYDIVKSARIYAGQGYTEHQAQEEWNMILHVLFEEETESSASSESIHEKNDNGTNECTSSFETLFEQEPSSEVPKDSKLYMLAQKTVQHIEQYGKAPDFNKVIRAHNFIQTIHGTPLKEEEKEVVRLMVIKLLKKK
What is the function of this protein?
Modifies the subcellular distribution of heterogeneous nuclear ribonucleoprotein K (HNRNPK) and may contribute to modulate HNRNPK functions related to processing and export of mRNAs during ASFV infection (By similarity).  Necessary for virus internalization (By similarity).
What are the official names of this protein?
Phosphoprotein p30, p30, Phosphoprotein p32, p32.
What is the protein family that this protein belongs to?
Belongs to the asfivirus phosphoprotein p30 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Virion.
Protein: THIE_SHISS
Sequence: MYQPDFPPVPFRLGLYPVVDSVQWIERLLDAGVRTLQLRIKDRRNEEVEADVVAAIALGRRYNARLFINDYWRLAIKHQAYGVHLGQEDLQATDLNAIRAAGLRLGVSTHDDMEIDVALAARPSYIALGHVFPTQTKQMPSAPQGLEQLARHVERLADYPTVAIGGISLARAPAVIATGVGSIAVVSAITQAADWRLATAQLLEIAGVGDE
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: PXPA_CHLSY
Sequence: MLTIDINCDCGESYGAFQVGDDDGILPFVSSANVACGGHAGDPMVMRRTVRRCRDLGVAVGAHPSYPDLYGFGRRVLPLTPDEIEAWVLTQIGSLAAIARSEKVELRHVKPHGALYNVAARDLTVAMAIARAVAAFSRELALVGLAGSLLITAGHEVGVPVLAEAFADRTYEADGTLRNRHHPDALIIDPAACLAQTLHIIRDGAVRAVDGTLVPLQAATICIHGDTPGAALRAATIRQGLAAAGITVQAPQR
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: VP7_RRSVT
Sequence: MDELTLSIGGSPGKLAGTQLLYKQKIDKEIRLSPTDLLFSSNTVDHKLRNKRTTIALLSREVQARLGKWMISFADQKGTAADFGLQLAKWVQASTQLHYYVHPADMSALRAADQSLIRQLPRVTVEVCKTKKVSQTDPIEHKYQSRPGMIEGGVTITPRQAVTLEEIYPLASRPEKGVIMFMLSQAHLEHLIHPVIKQVSNYFTCVKVGTSGFSLNYNHPYIRAMFLEPITACDVVELPLQALHARFSAGKGHLYLCGDGHAPRTLTCAQMFDIPHVHDFTMPSVTVVSFYAPEQHIAIARYASWYEKDTICRLLQSTLPDVEKLVWLCAMSYPIFPSLRPTLTGSIFSRCKVVVSVSAERSRLLSDGLPKWAEWVDNVLSDRIAKPACLILIGPKASSKSFVTRQLVAKLNASSLSVEGDNFGRVDSDAFGKWVTMMVSNSTLPTSWAQFDLMQNDKEIASYVDIRFNDICVKHGFCELDDLRTKNAGVLQGEFARSFIEIIKDPSCGLRAFFSWLFSLYGLPRGLMLESHTNVEIAEYPPTTCILQLLPNYDVMSVLLERDARKGISKLAEMQMEEYYNGLRIGTYRSVLACELLRVAEVGPPVEG
What is the function of this protein?
Minor inner capsid component.  Displays NTPase and RNA 5'-triphosphatase (RTPase) activities.  May function as a cofactor of polymerase.  Associates with microtubules and plays a role in the formation, structural organization and morphology of viral inclusions, where the assembly of cores and the replication of viral RNA occur (By similarity).
What are the official names of this protein?
Microtubule-associated protein VP7.
What are the subcellular locations of this protein?
Virion. Host cytoplasm, host cytoskeleton.
Protein: GRXC8_ORYSJ
Sequence: MAALLGRRFGMAAAALIALAALGSAASGTASKSSFVKSTVKAHDVVIFSKSYCPYCRRAKAVFKELELKKEPYVVELDQREDGWEIQDALSDMVGRRTVPQVFVHGKHLGGSDDTVEAYESGKLAKLLNIDVKEDL
What is the function of this protein?
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase.  Reduces low molecular weight disulfides and proteins (By similarity).
What are the official names of this protein?
Glutaredoxin-C8, Glutaredoxin-C4 homolog.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. CPYC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_ECO81
Sequence: MTKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGTFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTEDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENDLGVGYYQP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC134_RAT
Sequence: MDLLQSLAVFFVLLLPGTEVTGTLKSTLDPSLKIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLIAADVLPDGPLPQDEKLKDAFSHVVENTAFFGDVVLRFPKIVHHYFDHNSNWNLLIRWGISFCNQTGVFDQGPHSPVLSLMAQELGITEKDSDFQNPFTIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL
What is the function of this protein?
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and promotes H3K14 and H4K8 HAT activity.  May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity.  May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
What are the official names of this protein?
Coiled-coil domain-containing protein 134.
What is the protein family that this protein belongs to?
Belongs to the CCDC134 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum. Note=Accumulates in the nucleus in response to UV irradiation.
Protein: PYRF_METI4
Sequence: MDLKPIVALDLPDPSEALKLVHLLRPHIDFFKVGSQLFLAGGTDIIRRIIDCGADVFLDLKFHDIPRTVFRAVTEVVKLKVKFTTVHILGGREMLKEALEASAGSDTEILGVTVLTSMDDRGLESIGIAHAVEEEVLLLASMALEVGLRGIVCSGKELPLLGKLKKRASILVVPGIRWRGAAAYDQKRIIEPGEAKKGGATHVVVGRPILEAHDKVGLVQKLLCELNAIN
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: RUVB_CHLCH
Sequence: MRIELLNTPPDAAESRFEEQIRPIRMEDFAGQQRLTDNLKVFISAAKMRGDALDHVLLSGPPGLGKTTLAYIIASEMGSSIKATSGPLLDKAGNLAGLLTGLQKGDILFIDEIHRMPPMVEEYLYSAMEDFRIDIMLDSGPSARAVQLRIEPFTLVGATTRSGLLTSPLRARFGINSRFDYYEPELLTRIIIRASSILGIGIEPDAAAEIAGRSRGTPRIANRLLRRARDFAQVDGISTITRTIAMKTLECLEIDEEGLDEMDKKIMDTIVNKFSGGPVGIASLAVSVGEERDTIEEVYEPYLIQAGYLARTTRGRVATRKAFSRFADHTLLGGNFGGHKGSLPLFDESEAD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.