PharMolix/UniProtQA huggingface dataset:
Protein: ENDO3_ARATH
Sequence: MGWSLRMWIVSILVLTQLVNGALCWGDAGHYAVCKIAQSYFEEDTVVAVKKLLPESANGELAAVCSWPDEIKKLPQWRWTSALHFADTPDYKCNYEYSRDCPKDWCVTGAIFNYTNQLMSTSENSQSIVHYNLTEALMFLSHYMGDIHQPLHEGFIGDLGGNKIKVHWYNQETNLHRVWDDMIIESALETYYNSSLPRMIHELQAKLKNGWSNDVPSWESCQLNQTACPNPYASESIDLACKYAYRNATAGTTLGDYYFVSRLPVVEKRLAQGGIRLAGTLNRIFSAKRKLARA
What is the function of this protein?
Endonuclease that can use RNA and single-stranded DNA as substrates (PubMed:23620482).  In contradiction with PubMed:23620482, cannot hydrolyze single-stranded DNA and does not cleave mismatches (PubMed:17651368).
What are the official names of this protein?
Endonuclease 3, AtENDO3, Deoxyribonuclease ENDO3, Single-stranded-nucleate endonuclease ENDO3.
What is the protein family that this protein belongs to?
Belongs to the nuclease type I family.
Protein: CH10_NOVAD
Sequence: MTFRPLHDRVLVRRVEAEEKTAGGIIIPDSAKEKPAEGIVVAVGSGARAENGTITPLDVKANDRVLFGKWSGTEVKVDGEDLLIMKESDILGVIG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1086_METJA
Sequence: MKVRIRDFIETTEGLYFAVNTYAHPKNKFFAFLRYVPYEFVDFKIEDNNIREINGRKYIKMAESKIAYKFLEEKFSKYLYYDETINVLMHAIPKEDVKRILRPKERLNEIINEENNLNELEEKCRKLALILEDYGVPIKSMGVSGSLLLKLNNKNSDIDFVIYGKDMHKKAREALKQAFEDNKLKPLSDDFWKIAYKKRIKDKTLTYEEFVFYEKRKYNRGIVDNTMFDLLFTREWDEITEKYGDKRYKNLGFAKIEGRVLNDDFAFDNPAVYKIECYNDEDIKEVVSFTHTYAGQCFNGEEIVARGKLEEVIDKSGERYKRIVVGTTREAFNEYIKIKR
What are the official names of this protein?
Uncharacterized protein MJ1086.
Protein: ACCD_METS4
Sequence: MKVETMNWITEVVRPRIKTLFKRETPENLWVKCPETGQMVFHKEVEAHDFVIPGSEHHLRMSAQQRLKMMFDQGTWLDVPLPEAPVDPLKFRDEKRYVDRLKDARAKTGMADAFKVGFGRVGGLPMTLAVQDFGFMGGSLGMAAGEAFVRGAETALDKRTPYVLFAASGGARMQEGILSLMQMPRTTVAVRRLNRARLPYIVVLTNPTTGGVTASYAMLGDVHLAEPGALIGFAGPRVIEQTIREKLPDGFQRAEYLREHGMIDQVVHRRDLKATVARLCGLLMQAPAATPAPASAAAQPVPA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_PARXL
Sequence: MQVTSQFKTVALVGRNNTPGIAEPLTALALCIAKRGFEVVFEADTAAEIGVTDYPALRPAEIGARADVAVVLGGDGTMLGIGRQLAPYRTPLIGINHGRLGFITDIPISDMREIVPQMLAGNFEREERVLLEARIMRDGNPIYHALAFNDVVVNRSGFSGMAELHVSVDGRFMYNQRSDGLIVATPTGSTAYALSSQGPILHPQLQGIVLVPIAPHALSNRPIVLPDDSKVSIQIVSGREVNVNFDMQSFTSLELSDTIEVRRSRHTVPMLHPVGYSYFATLRKKLHWNEYPSHEEDPKP
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRDM5_HUMAN
Sequence: MLGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDMEAEEEEQQIMTVIKEGEVENSRRQSTAGRKDRLGCKEDYACPQCESSFTSEDILAEHLQTLHQKPTEEKEFKCKNCGKKFPVKQALQRHVLQCTAKSSLKESSRSFQCSVCNSSFSSASSFEQHQETCRGDARFVCKADSCGKRLKSKDALKRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYKCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKICPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYKCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPLAECQFCHKKFTRNDYLKVHMDNIHGVADS
What is the function of this protein?
Sequence-specific DNA-binding transcription factor.  Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.  Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes.  May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2.  May cause G2/M arrest and apoptosis in cancer cells.
What are the official names of this protein?
PR domain zinc finger protein 5, PR domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CBCL2_ARTSP
Sequence: MRTAFELVAWSAHRQPGAVALLDPESGHRLTYSELLKRIEGVATVLASRGVVRDELVATAMANTLDHAIILLALNRLGAIPVIINPRLKADEMVQLIRRDNIRTVIRTVAEGKSGTPADIDGVEELTLSAEVLSEGLRIDGNATPAFEAPRPEDPAFVFYTSGTTGLPKGVVIPHRAIEPRVLFMSTQAGLRFGGHNNLLGLMPIHHVIGFFGVFLGSLAFNGTWIPVTAFDPAQAVKWVEELDVTCLFASPTHFDALLATSEFAPEKLKSVDSVIFAGAAINQSILKRLEKCLQVPIVDIYGTTETMNSLFNPDATQERGLRPGYHSRVQFASVSESPSVALPAGVEGELVVDASADATFTHYLNNPEATAAKIVDGWYRTGDSGYVDDSGRVILTGRIDDMINTGAENVHAEEVEQIISRHPAVVEAAVVGLPDTRWGEVVTAVVVVSEPLTADLLDQVCLDSELANFKRPRRYFVVNELPRNAAMKVSRRTLREYLGAHAADQPNPETGFIQFTIEESQ
What is the function of this protein?
Catalyzes the formation of chlorobenzoyl-CoA via a 2 step reaction.  First 4-chlorobenzoate is adenylated by ATP, followed by acyl transfer from the 4-chlorobenzoyl-AMP intermediate to CoA (By similarity).  Benzoate, 4-bromobenzoate, 4-iodobenzoate and 4-fluorobenzoate also act as substrates.  Inactive towards 4-nitrobenzoate.
What are the official names of this protein?
4-chlorobenzoate--CoA ligase, 4-CBA:CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: HEMH_ECOUT
Sequence: MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALEMAPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_SALG2
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETIEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: ARCA_LISMF
Sequence: MKMEQALNITSEIGKLQTVLVKRPGSELENITPEYLESLLFDDIPYLKMMQKEHDFFAKTMKDSNIEVLYLEKLAAEALREANNKESFLTKMIKESNQMDESALYVRDYLMSFDEEEMIRKLMSGLKKSEIPERKKKHLNEMMDEQYPFFLDPLPNLYFTRDPAAVIGNGVTINRMFQPARRRESMFIELILKHHPRFSNQEIPVWSGRGEPFSLEGGDELVLNEETVLVGVSERTDARAVERLAESLFSRSPKIKRVLAVEIPETRSFMHLDTVFTMVNFAQFTIHPAIQNQQGELNIYILEKSENGLEITPRRDFQRVIAEVLDEPEIDFIPCGGEDVIVSAREQWNDGANTLAIAPGEVITYDRNQVSNDLLRSAGIKVHEVISSELSRGRGGPRCMTMPLVRENLK
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_RHOP2
Sequence: MTLAVAVAPLEKTPLETYVPPAKPSLIGLSRAELAERLGAIGVAPAQRKMRAQQLWHWMYVRGARDFAEMTNVSKEMRATLAEHCTVDRPEVVAEQISADGTRKWLLRLPSGDDVQKAHEVECVYIPETDRGTLCVSSQVGCTLNCSFCHTGTQRLVRNLTAGEIVGQVMVARDRLGDWIDRETPNGNRLVTNVVMMGMGEPLYNFEAVRDALLIVTDNEGIGISRRRVTLSTSGVVPNIARTGDEIGVMLAISLHAVRDELRDELVPLNRKYPLKELLQACRDYPGASNARRITFEYVMLKGVNDSLDDARRLVQLLKGIPAKINLIPFNPWPGSKYECSDWDQIEKFSEYVFNAGYSSPVRTPRGRDILAACGQLKSETEKLSVRERDALRAMAMTD
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_STAAM
Sequence: MLQHKILGLDVGSRTVGIAISDIMGWTAQGLDTLRINEENNELGIDQLVDIIKKHNVGTVVIGLPKNMNNSIGFRGEASLTYKEKLLEAYPSIEIVMWDERLSTMAAERSLLEADVSRQKRKQVIDKMAAVFILQGYLDSLH
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_RUBXD
Sequence: MEQTLVLIKGDGVRRRLIGEIIRRLENKGLAIRDLKMMRVSRELAEEHYAEHREKPFFGELVEFITSAPVVAMRVEGEGAIGVVRNLMGATDPAKAAPGTIRGDLALSMPDNLVHGSDSPQSAARELRLFFGG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_PSEA8
Sequence: MILELDCGNSLIKWRVIEGAARSVAGGLAESDDALVEQLTSQQALPVRACRLVSVRSEQETSQLVARLEQLFPVSALVASSGKQLAGVRNGYLDYQRLGLDRWLALVAAHHLAKKACLVIDLGTAVTSDLVAADGVHLGGYICPGMTLMRSQLRTHTRRIRYDDAEARRALASLQPGQATAEAVERGCLLMLRGFVREQYAMACELLGPDCEIFLTGGDAELVRDELAGARIMPDLVFVGLALACPIE
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_ALIFM
Sequence: MTATNELLQDLKARGLIAQCTADEELAEHLSTDCRTLYCGFDPTADSLHIGSLVPLLVLKRFQQAGHKPLALVGGATGLIGDPSFKAAERQLNTNEVVGDWVNKIKAQVSAFVDFTEEKNGAEVVNNLDWIGQINVIEFMRDVGKHFSVNAMIQKESVKQRIDREGSGISFTEFSYMLLQSYDFAALNKAKECTLQIGGSDQWGNITGGIDLTRRMNRNKVFGLTLPLVTKSDGTKFGKTESGTIWLDSNKTSPYAFYQFWLGTADADVYNFLRFFTFLTVEEIAAVEESDKSVQGRPEGQGILAREVTRLVHGEEGLASAERITKALFSGDLSSLTETDLAQLALDGLPSTELEASEQTIVEVLTQSELAKSNKMAREFIGNGAVSVNGEKVADTEAVLKKEDALFGKYSVIKRGKKLFNLYIWK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAR1B_DICDI
Sequence: MFLVDWFYNMFLWLGFFKKEAKIVIIGLGNAGKTTLLHLLVTGSLKSHIPTLRPNAESFTYGNVNFKAYDLGGQQNLRFLWKQYVPDSKTIIVFMVDSSDYNSIIESKSEIHDILGDEHLSQSPLLILGSKCDAKGHHNRENLIDLLDIRRFELGLNNSNNVPFDLIMTSSITRYGITDMLNWLDKCTDIIKNN
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
GTP-binding protein Sar1B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. SAR1 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SMP3_EMENI
Sequence: MWRRTYLLLLLIRAYFALSPSYIHPDEHFQGLEVFAGRILSYPSRLPWEFTSERPIRSVFPLYPIYGVPISLLKWFYTETGTESPPAELVYYVVRGVMFLLSFVLEDWAVHDLVPLPRHRRVALVLVASSYVTWTHQTHTFSNSLETLLVAWGLVLINRIIDNKRRSSLFSCAILSFICVAGIFNRITFPAFLVLSLGLVVYNFPRRPLSFFSLVGFGLVFFCIAVFADTTFYKPSASFADVLRSPVITPLNNLLYNTDNSNLALHGLHPHYNHFLVNLPQLLGPALVAMVLQAYNRGFIASWFKNLRAASALSATAMLSIFPHQEPRFLIPCVPLLLSCLQVRKSRIFLGAWVIFNATLGFLMGVYHQGGVVSTQLAVPSVISTTTSLWHESLKGTQSLFATVVWWKTYSPPLWLLGDNSTLNLNIDTRDLMGKPGSEMVKELERLVPTCGSKQKSTELTSSLEQPDAVFVVAPKSVTFLDQFLAPQSPDSSLELLELWSYKKHISLDDLDFGSDGVLPTMKRVIGRRGLGVWLAQRPGCRAIDS
What is the function of this protein?
Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly.  The presence of a fourth mannose in GPI is essential in fungi (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 4, GPI mannosyltransferase IV, GPI-MT-IV.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 22 family. PIGZ subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VIP1_PONAB
Sequence: MWSLTASEGESTTAHFFLGAGDEGLGTRGIGMRPEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVIILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESIVRKTGSYIYEEFMPTDGTDVKVYAVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFRQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVKHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGKLEQLKSVLEMYGHFSGINRKVQSTYYPHGVKASNEGQDPQRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYDELAPTRSTSLLNSMTVIQNPVKVCDQVFALIENLTHQIRERMQDPRSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGAAELLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLESHVHSLLSVFRYGGLLDETQDAQWQRALDYLSAISELNYMTQIVIMLYEDNTQDPLSEERFHVELHFSPGVKGVEEEGSAPAGCGFRPASSENEEMKTNEGSMENLCPGKASDEPDRALQTSPQPPEGPGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSFSAPNLQDYARSHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLHQVSEFLSRVCQRHTDAQAQASAALFDSMHSSQASDNPFSPPRTLHSPPLQLQQRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSQFGFSDQPSLNSHVAEEHQGLGLLLETPGSGAQELSIEGEQELFEPNQSPQVPPVETSQPYEEVSQPCQEVPDISQPCQDISEALSQPCQEVPDISQQCQENHDNGNHTCQEVPHISQPCQKSSQLCQKVSEEVCQLCLENSEEVSQPCQGVSVEVGKLVHKFHVGVGSLVQETLVEVGSPAEEIPEEVIQPYQGFSVEVGRLAQEASAINLLSQGIPEIDKPSQEFPEEIDLQAQEVPEEIN
What is the function of this protein?
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4.  PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation.  Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4.  Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.  Activated when cells are exposed to hyperosmotic stress.
What are the official names of this protein?
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1, Diphosphoinositol pentakisphosphate kinase 1, Histidine acid phosphatase domain-containing protein 2A, InsP6 and PP-IP5 kinase 1, VIP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway.
Protein: RS3_BORDL
Sequence: MGQKVHPYSLRIKINRDWKSKWYFDKKLYSEILHEDFLIRRETMKFLKGIKFDISDIEIIRNNLQRVTVVISTPRPGSVIGVKGANLEKIGQLLTRKVSKKINIKIKEIKKPEFDAQIVANGIAKQLENRASYRKLLKSSLLSSISKGIQGIKIKVSGRLGGAEIARSFEVKEGRIPLHTLRANIDYGFAEAYTTYGVIGVKVWLFKGEILGKQINSDAGQVINRKPSKDKVERFDKGKIDDKGRKVVNDDKFSREKLEIGSRSKNDFKNKNDSDI
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CHSTA_PONAB
Sequence: MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDVYSAKQEFLFLTTMPEVRKLPEEKHIPEELKPTGKELPDSRLVQPLVYMERLELIRNVCRDDALKNLSHTPVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFPSIEEIPENVVHDHEKNGLPRLSSFSDAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTESRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEIMYSVIGHHETLEDDAPYILKEAGIDHLVSYPTIPPGITVYNRTKVEHYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN
What is the function of this protein?
Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides.  Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult.  May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.  Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase.  Likely defines the chain length of LG epitope, confering binding specificity to extracellular matrix components.  Plays a role in down-regulating the steroid hormones.  Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility.  Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones.
What are the official names of this protein?
Carbohydrate sulfotransferase 10, HNK-1 sulfotransferase, HNK-1ST, HNK1ST.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: NUP53_CHATD
Sequence: MPPLILHNVPDDELYVGDDGIQRPFAMVFPQQDGSLRSRKANLETGAFGKSTRRTRSKAATPAKREDPTIAAADKIFSNWLASQNQSAPQTSVPAPAQRKPNLIPSSSSQNLAQGHDESSAPSQTRFFRKQEPTEVILRGYRNAQHQYAAINHYEQIAGRICEDYPREPPVESRRYKSELRDPAFTHRRALTPEERAKVNRAMSGEHWVKVTFESAEAADKAVYSSPQLIQGHLVYAEYYKGVPPAQDEAIPDPSVAAFGAALSRTQTLRQRNRGSFSLSGTQEAGGPDASPTSSLTADTGTLASGVEISTSTSNTLNGGAAAGGAEKSQDDEFCRVIPTVRKAKLLPMEEALLPAPTFTQRIANHIPFLRWFNGAMIGSEVPRTETGEFDWVRASLFWKLMWWLDFLLGLFGGDIRDAEKDDKED
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).
What are the official names of this protein?
Nucleoporin NUP53, Nuclear pore protein NUP53.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
Protein: NUSA_BUCBP
Sequence: MNKEILAVVEAVSNEKSLPREKIFEALECALAIATKKKYDQEIDVRVKINRKNGNFETFRRWLVVNQVLQPTKEITLEAAKFEDVTVKVNDYIEDKMISVTFDRITTQTAKQVIVQKVREAERAMIVEQFRKYFGKILTGIVKKINRESITLDLGNNAEALILKEDMLPRENFRLGDRVRGVLYAIYPESRGAQLFVTRSKPEMLIELFKIEVPEIGEEIIEIKSAARDPGSRAKIAVKSNDKRVDAVGACVGMRGARVQAVSSELCGERIDIVLWDKNSAQFIINSMAPAEVSSIVLDEDRHTIDIAVDSNNLAQAIGRNGQNVRLASQLSGWEINVMTVDDLKLKHQEEKDKILNIFTKYLKIDQKISNILIDEGFSSIEELVYIPFNELLNINSITQELAYSIRESAKKALCAIELENKKVINERKLHKDLLNLKGMNQKLAFKLAKKNIFSLEDLAEQGIDDLIDIENLNSNTAGMLIMAARNICWFGNKTSA
What is the function of this protein?
Participates in both transcription termination and antitermination.
What are the official names of this protein?
Transcription termination/antitermination protein NusA.
What is the protein family that this protein belongs to?
Belongs to the NusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_PEDPA
Sequence: MEMNLQFFSHHKGGGSTSNGRDSAGRRLGTKRADGQAAKAGMIIYRQRGTHIYPGVNVGRGNDDTLFALADGVVRFERKGRDKRQVSVYPVADAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PXPA_ECOSE
Sequence: MKIDLNADLGEGCASDAELLTLVSSANIACGFHAGDAQTMQACVREAIKNGVAIGAHPSFPDRENFGRSAMQLPPETVYAQTLYQIGALATIARAQGGVMRHVKPHGMLYNQAAKEAQLADAIARAVYACDPALILVGLAGSELIRAGKQYGLTTREEVFADRGYQADGSLVPRSQPGALIENEEQALAQTLEMVQHGRVKSITGEWATVTAQTVCLHGDGEHALAFARRLRSTFAEKEIVVAA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: HISZ_STAA8
Sequence: MNNSEQLIALKESETAFLKYFNKADYELVDFSVVEKLDWKQLNHEDLQQMGERNFWQHEHQIYALRNDFTDQLLRYYSMYPTAATKVAYTGLIIRNNEAAVQVGLENYAPSLANVQQSLKLFIQFIQQQLRDNVHFVVLGHYQLLDALLDKSLQTPDILSMIEERNLSGLVTYLSTEHPIVQILKENTQQQLNVLEHYIPNDHPALVELKIWERWLHKQGYKDIHLDITAQPPRSYYTGLFIQCHFAENESRVLTGGYYKGSIEGFGLGLTL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.