PharMolix/UniProtQA huggingface dataset:
Protein: MUTS_CUPPJ
Sequence: MQEKIELNQEVAKPLAEKHTPMMQQYLRIKADHPDTLLFYRMGDFYELFHDDAEKAARLLDITLTARGSSNGVPIRMAGIPFHSADQYLAKLVKLGESVAICEQIGDPAASKGPVERKVVRIVTPGTLTDASLLPDKSDTFLMAVHQQTTRRGVSKTGLAWLNLASGELRLMECEAAQLAREFERIRPAELLYADGIDLPAVACARTRLPEWHFDQDAGTRRLLEQLGVASLEPFGCAGLGAAIGAAGALLNYAATTQGQSLRHVRDIKVERESEFVGLDSATRRNLELTETLRGGESPTLFSLLDTCATAMGSRALRHWLHHPLRDPALPRARQQAIGVLIDHGIDDLRSALRKLADVERITSRLALLSARPRDLSSLRDTLRALPHVRACLQAEPDSSLLSLTVAELAVPQACLDLLISAVAEEPATVVRDGGVIARGYDAELDELRDISENCGQFLVDLESRERTRTGIANLRVEYNRVHGFYIEVTNGQADKVPDDYRRRQTLKNAERYITPELKAFEDKALSAQDRALAREKQLYDVLLQALLPHIGELQRVAGALARLDVLASLAERAQTLDWSCPERVGDNVIDIVQGRHPVVEGQLAAESVPFIANDCQLNEARKLLLITGPNMGGKSTFMRQTALIVLLACVGAYVPARRAVIGPVDRIFTRIGAADDLAGGRSTFMVEMTEAAAILHHATPASLVLMDEIGRGTSTFDGLALAWAIARHLLSHNRSHTLFATHYFELTQLPQEFPQAANVHLSAVEHGDGIVFLHAVQDGPASQSYGLQVAQLAGVPQPVIRAARKHLAWLEQQSADATPTPQLDLFAPPPHPDTSDDDEPVSIGKPVQVALLPEQAAVLDALSDLDPDSLTPRAALDALYRLKVLAGEVVDAA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: GSH1_PHOPR
Sequence: MAFMDFSQRLQQISANSDALTQLGRGLEREALRITSEGNLSEQPHPVGLGSALTNKWVTTDYAESLLEFITPVSQDVDHLLTQLSDIHQFTYRQMGDERLWPMSMPCFVGKENDITLAQYGSSNTGRMKTLYREGLKHRYGSVMQVISGVHFNFSFPESFWQELFGDQSEQDRQDSISDAYFGLIRNYYRFGWLIPYLFGASPALCGSFLNKHNSSVDFKQLGCGTYYLPNATALRLSDLGYTSNAQSSLKIGFNSLDQYLDGLNQAIRTPSDDYADIGVKVEGEYRQLNSNVLQIENELYAPIRPKRVAKDGEKPSEALGRAGVEYIEVRSLDVNPFSPIGITEDQVRFLDLFLTWAVLTPSDDMDDSELACWRDNWNRVVLDGRNPDLMLKIGCNGERLSLQDWGVRVFKELQDVAVVMDKAAGNNKYQETCERLKGWVLNPDLTLSAQLLEKVKQNEGIGSVGHQLAAEHSQTLAERSYGFYSQPEFDVEAKISVEKQQKIEQGDTVSFEQFLDDYFADLK
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: MNME_BACFN
Sequence: MNQDTICAIATAQGGAIGSIRVSGPEAITITGRIFTPAKSGKLLSEQKPYTLTFGRIYNGEEMIDEVLVSLFRAPHSYTGEDSTEITCHGSSYILQQVMQLLIKNGCRMAQPGEYTQRAFLNGKMDLSQAEAVADLIASSSAATHRLALSQMRGGFSKELTTLREKLLNFTSMIELELDFSEEDVEFADRSALRRLADEIEEVIARLANSFSVGNVIKNGVPVAIIGETNAGKSTLLNVLLNEDKAIVSDIHGTTRDVIEDTVNIGGITFRFIDTAGIRETSDTIESLGIERTFQKLDQAEIVLWMIDSADAISQLTLLSDKILPRCEHKQLILVFNKVELINETQKNELASQFSEHIGSEIESIFISAKQRLHTDELQQRLVAAAHLPTVTQNDVIVTNVRHYEALTRALDAIHRVQEGLDANISGDFLSQDIRECIFHLSDIAGEVTNDMVLQNIFAHFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTD_SORC5
Sequence: MSTHFIDGSWVTGAGEPFASRNPVTQAVVFEGRAASEEQVDAAVAAARGAFAAWRDRGLEERAALVKRFAGVLGEHKARLADVIGLETGKPRWEALTEVQTMIGKIDVSLMAWRERTGERQAEAGDATAVVRHRPHGVVAVLGPYNFPGHLPNGHIVPALIAGNCVVFKPSELTPRVAEETARLWEKAGIPAGVLNLVQGGRRTGVALAGHPGIDGLFFTGSSGTGNALHRQLAGQPEKILALEMGGNNPLIVQDVANTEAAIHHILQSSFISAGQRCTCARRLLVPATPEGDALLGRLVDAASRLKVGRYDDAEQPFMGAVISLAAADRLLAAQARLVSLGGEVLLEMRRLEEGTALLSPGILDVSAIKELPDEEHFGPLVQVQRYGSFDEALSLANRTRYGLAAGLISDRRELYERFWRESRAGIVNWNKPLTGASSAAPFGGVGSSGNHRPSAYYAADYCAYPVAGLEAAAVALPGQLAPGMRLNS
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: SH2B1_HUMAN
Sequence: MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQEPTTSHDPPQPPEPPSWTDPPQPGAEEASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAGSGGDAGVPPMVQLQQSPLGGDGEEGGHPRAINNQYSFV
What is the function of this protein?
Adapter protein for several members of the tyrosine kinase receptor family.  Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs).  In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues.  These phosphotyrosines form potential binding sites for other signaling proteins.  GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1.  In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways.  In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2.  Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway.  Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity.  Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1.  For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2.  Enhances RET phosphorylation and kinase activity.  Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity).
What are the official names of this protein?
SH2B adapter protein 1, Pro-rich, PH and SH2 domain-containing signaling mediator, PSM, SH2 domain-containing protein 1B.
What is the protein family that this protein belongs to?
Belongs to the SH2B adapter family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: T23O_BURO0
Sequence: MQPPGGDAPAGCPFSGARAAQPAQAAHEAPHVPGEADAQAGWHNAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKNAQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: VATC_THEGJ
Sequence: MGAETVTAILDTTLGVVFTWLGWKTAKIIRKYTPYSYPNARINAMEAKLLTGQRFNELAESRTLQNFIVNLEDTDYKVHLSGVTEDPLEIERAFERALASTYLLMEEILPKRVSGFFRLLLEEWDVRNIASVVKAKVRGEPAIDYVVEIGTMVPKVKAIAEAKTMEEILVILEGTPYEEHYQRLLLGEIDVDQFETELYKVYYSRLLEYATSRKEEERLILEEFVRTKIDIRNIVTLLRAKRAGLPGEVIKRHLIPGGSVKLDTALNVDDLGMALAELDSTKYGKVLRDEREKIEKDLTLVEPVLQNHLLRRMEELTRFYPLSVATPLSYILKKEREIKKLRAMAKLIADGFEPEKIKEIIGEELA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit C, V-ATPase subunit C.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
Protein: RAPZ_YERPE
Sequence: MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPQLASTLADRNISAAVSIDVRNMPESPEVFEHAMTQLPDSFSPQLLFLDADRNTLIRRYSDTRRLHPLSAKNLSLESAIDEESDLLEPLRSRADLIIDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVISFLDRHTEVHNFIYQTRSYLEQWLPMLETNNRSYLTVAIGCTGGKHRSVYVAEQLADYFRARGKNVQSRHRTLEKRKQ
What is the function of this protein?
Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ.  When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E.  Consequently, GlmZ is inactivated and unable to activate GlmS synthesis.  Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
What are the official names of this protein?
RNase adapter protein RapZ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family. RapZ subfamily.
Protein: Y293_STRS7
Sequence: MGRKWANIVAKKTAKDGATSKVYAKFGVEIYVAAKQGEPDPELNTALKFVIDRAKQAQVPKHVIDKAIDKAKGNTDETFVEGRYEGFGPNGSMIIVDTLTSNVNRTAANVRAAYGKNGGNMGAAGSVSYLFDKKGVIVFKGDDADSIFELLLEADVDVDDVEAEDGSITVYTAPTDLHKAILALRESGISEFQVTELEMIPQSEVTLEGDDLAVFEKLVDALEADDDVQKVYHNVADV
What are the official names of this protein?
Probable transcriptional regulatory protein SZO_02930.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIF3C_RAT
Sequence: MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTPGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDNNNNHRPPQPTLEAALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYSSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFLDCEEEQWKFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPAIFEMEFSHDQEQDPRVLHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPPSTVHASMASAPLHPATVVDHD
What is the function of this protein?
Microtubule-based anterograde translocator for membranous organelles.
What are the official names of this protein?
Kinesin-like protein KIF3C.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: FRS11_ARATH
Sequence: MSDDPGQMLLIYDDPSDQRSLSLDDASSTEESPDDNNLSLEAVHNAIPYLGQIFLTHDTAYEFYSTFAKRCGFSIRRHRTEGKDGVGKGLTRRYFVCHRAGNTPIKTLSEGKPQRNRRSSRCGCQAYLRISKLTELGSTEWRVTGFANHHNHELLEPNQVRFLPAYRSISDADKSRILMFSKTGISVQQMMRLLELEKCVEPGFLPFTEKDVRNLLQSFKKLDPEDENIDFLRMCQSIKEKDPNFKFEFTLDANDKLENIAWSYASSIQSYELFGDAVVFDTTHRLSAVEMPLGIWVGVNNYGVPCFFGCVLLRDENLRSWSWALQAFTGFMNGKAPQTILTDHNMCLKEAIAGEMPATKHALCIWMVVGKFPSWFNAGLGERYNDWKAEFYRLYHLESVEEFELGWRDMVNSFGLHTNRHINNLYASRSLWSLPYLRSHFLAGMTLTGRSKAINAFIQRFLSAQTRLAHFVEQVAVVVDFKDQATEQQTMQQNLQNISLKTGAPMESHAASVLTPFAFSKLQEQLVLAAHYASFQMDEGYLVRHHTKLDGGRKVYWVPQEGIISCSCQLFEFSGFLCRHALRVLSTGNCFQVPDRYLPLRWRRISTSFSKTFRSNAEDHGERVQLLQNLVSTLVSESAKSKERLDIATEQTSILLSRIREQPVSSLAIRDISSSVQRNF
What is the function of this protein?
Putative transcription activator involved in regulating light control of development.
What are the official names of this protein?
Protein FAR1-RELATED SEQUENCE 11.
What is the protein family that this protein belongs to?
Belongs to the FHY3/FAR1 family.
What are the subcellular locations of this protein?
Nucleus. Note=The nuclear localization is independent of the light treatment.
Protein: VM1A3_DEIAC
Sequence: PAPQTSIELFLIVDHSMYAKYNSNSSKITTTLKARVNIMNAIYSSLNLVITLSGIEMWSAADLITVQSSSRNTLKLFASWRETDLLKRTSNDNAQLLTATNFNGNTVGLAYLKTMCNSKYSVGLIQDHSAIPLLMAVTMAHELGHNLGMNHDGAGCSCATCIMAPVLSSGPAKSFSDCSKHDYQSFLTIHKPQCLLN
What is the function of this protein?
This protein is an alkaline zinc metalloprotease from snake venom that possesses weak hemorrhagic activity.
What are the official names of this protein?
Snake venom metalloproteinase acutolysin-C, SVMP, Hemorrhagin III.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: COX2_APOSY
Sequence: MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTSDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKHFENWSASMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS3A_METHJ
Sequence: MAAKKPTGRRVDGWKAKSWYKVYSPDNVGKVYLGDTVADDPSKLMGRVMQAPLSELVNDYTKQNVKMKFAITNVAGDAAYTSFIGHELARDFIRSLVKRRTSRIDCVVNFVSKDGCKVRATVTCFTLTRADQSQQHEIRKILTDDVLTFGKENELGVFVNNIINGDLAKELFKKVKELHPVRRVEVIKTKVELPKSSA
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: COL11_HUMAN
Sequence: MRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM
What is the function of this protein?
Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343).  Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189).  Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189).  Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189).  Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189).  Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable).  Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481).
What are the official names of this protein?
Collectin-11, Collectin kidney protein 1, CL-K1.
What is the protein family that this protein belongs to?
Belongs to the COLEC10/COLEC11 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVC_HELPJ
Sequence: MALPVYYDKDIDLGVIQSLQVGIIGYGVQGEAQALNLRDSKVKVRIGLYQGSLSVSKAKKEGFEVLGVKELVQQSDVIMALLPDELHKEVLEKEVIPFLKEGQIIGFAHGFSVHFNQVVLPKGVGAILVAPKGPGSALREEYLKNRGLYHLIAIEQESSIHNAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAIVRMGFETLIKAGYPEELAYFECVHEVKLVADLLHYKGVEGLRKHISNTAEFGAIKAREPMGNLLEKRMQKILKKIQNGAFAKDFLLEKSLNYPRLNTERKALKETKIEQIGEILRAPFNHKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: OX26_BOVIN
Sequence: MRSPYSLPYLLFLPLGACFPVLDTEEPVDAVGGTGREMSWMDPARGRPFPWGSPGWPRAPYPHALLVTAKELRASGKARAGFQLRLGRQDDGSEATGLLLGEAEKVGGLLGTLAEELNGYSRKKGGFSFRFGRR
What is the function of this protein?
Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure.  May have orexigenic activity.  May promote aldosterone secretion by the adrenal gland (By similarity).
What are the official names of this protein?
Orexigenic neuropeptide QRFP.
What is the protein family that this protein belongs to?
Belongs to the RFamide neuropeptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: HOOK_DROME
Sequence: MSAPKNEMYYSLLEWFKTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSNWRLRMSNLKKVTQSVYDYYSDVLNYSLSDFSKPDLQRIAEKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQANIMRALQELEATRQASTPEGGVASSLSRGSRTGLLDSKAVQEDRDALAQKCFETEKKMLLLIDEKTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKEELLQSEGAREDLKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNKNLESKNLALQRAKDSLLKERDNLREAVDELKCGQLSSNTALTGTTVSRELQPSATVEKLQRLEAENKALREGQGGQTALAQLLDDANKRCENLREQLKTANERILSLSHASQSDDPILKESEFGKQIKQLMELNEQKTLQLEEAVTQSTSLQCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSIDPRIASALDASVLEKSADLVEEEPKPKMSVMEEQLMTSAFYRLGVNAQRDAIDSKLAILMGSGQTFLARQRQSAPRKSLSAMKSK
What is the function of this protein?
Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway.  Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton.  Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size.  Not involved in synaptic vesicle recycling.  Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs).  Has a role in regulating adult longevity.
What are the official names of this protein?
Protein hook, dHK.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Endosome. Synapse. Note=Enriched at neuromuscular synapses, in both presynaptic and postsynaptic regions.
Protein: ASTB_YERPP
Sequence: MAGYEVNFDGLVGLTHHYAGLSFGNEASTTHQNRTSNPRLAAKQGLLKMKALADLGYKQGVLPPQERPAIGVLRKLGFSGSDEQVLSDVARNAPRLLSAVSSASSMWTANAATVSPSADSADGRVHFTVANLHNKFHRAIEAETTAVLLPAVFNNHRHFVHHDALPSVTLLGDEGAANHNRLGGEYDSPAIQMFVYGRQGMESGAVPGRYPARQTREASQAVARLHQLDPKRTVFVQQNPAVIDQGVFHNDVIAVSNRNVLFHHELAFLSSTQVMDDIRCKMAGLEQQLVNIEVPEAEVSVADAVSTYLFNSQLLHKANGKMLLVIPQESQDNPSVWRYLSELVSGDGPIDELRVFDLRESMRNGGGPACLRLRVVLNDAELQAVNSRVMLTPALFVTLNNWVDQHYRDHLQFKDLADPHLLQEGRQALDELTRILNLGPVYPFQRN
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: Y503_ANOFW
Sequence: MQPFIFLFILLVIGMMAKNQSLIIAVLFLLIVKSIGLSSKVLPYLEQKGIQLGVTIITIAVLVPIATGKIGFKELAESVRSIYAWIAMLSGIAVALLAKGGVALLAKDPHVTTALVLGTILAVSLFKGVAVGPLIGAGIAYVIMKIVDVFS
What are the official names of this protein?
UPF0756 membrane protein Aflv_0503.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDS5B_CHICK
Sequence: MAHSKTRANDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDLLLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYSLQSEAGKEAAKQISWIKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETNERMKCLYYLYATLDSNAVKALNEMWKCQNLLRHQVKDLVDLIKQPKTDASSKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRSQLEMLVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGSKIEEDFPHIRSALLPVLHHKAKKGPPRQAKYAIHCINAIFSSKETQFAQIFEPLHKSLDPSNFEHLITPLVTIGHIAMLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETLVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQIFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNINVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDIKECLWFILEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDAKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARYFTQPDKNFSNTKNYLPPEMKSFFTPGKPKAANVLGAVNKPLSSAGKQSQSKSSRMETVSNASSSSNPSSPGRIKGRLDSTEMDHSENEDFTLSSPLPGKKTDKRDDSDLSELEKPRGRKKPAITDSEEKLSIDDLNKLGQDQKLRGSQRGRKRPAVVSESDETQWQEEKRLKEDVIESEDEQNSPPKKGRRGRPPKPNNGGTPKEEPAAKSSKRSKKKQTSAAAVEEEEEEEERQTENIEQKPKGRQNRSTKRTQQSRAGRSKQAASKENESSEEMDVFQSSSPVSDDVPQEEVMEEEEVSTINVRRRTSKRERR
What is the function of this protein?
Plays a role in androgen-induced proliferative arrest.  Required for maintenance of sister chromatid cohesion during mitosis (By similarity).
What are the official names of this protein?
Sister chromatid cohesion protein PDS5 homolog B, Androgen-induced proliferation inhibitor.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL17_LEPIC
Sequence: MNKRNKVKHLNRNKGHRDALINNMITSLFKYERIESTQAKLKVVRSHAEKLITRAKKNLVTDLKPEVQLHNKREVMKRIKDREVVVKLFEDIAKRFETKNGGYTRVLKLVNRISDNSEVGILELTSRKERSTLLKERIEKREIQTKAREEKRATRKSNSAPVSKETTSKKK
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.