PharMolix/UniProtQA huggingface dataset:
Protein: IBP6_HUMAN
Sequence: MTPHRLLPPLLLLLALLLAASPGGALARCPGCGQGVQAGCPGGCVEEEDGGSPAEGCAEAEGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLPARAPAVAEENPKESKPQAGTARPQDVNRRDQQRNPGTSTTPSQPNSAGVQDTEMGPCRRHLDSVLQQLQTEVYRGAQTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKSLPGSPDGNGSSSCPTGSSG
What is the function of this protein?
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.  Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225).
What are the official names of this protein?
Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6.
What are the subcellular locations of this protein?
Secreted.
Protein: G6PI_ECOSM
Sequence: MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSVTFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCES_ASPCL
Sequence: MENRSSSGTPRPSAGSPDAAKRPSETSPAAGRIPAGQNGSSGDKKRKVTEEGEASEKSEPPADRPMSKRKRMEERHQKLRKRGRTPPSAYSRRDAEAAPVPNRNRDDPANRSLSPLPHRSPTPEEQPRQRKRPGGGARMGLVDRETLRRRQEERERALVEEAMRTSQGRGVTDVVRQHYNAVPQRGREWRKTESKIKGLRSFNNWIKSTLIQKFSPDEEFLARLNDGRDWADDSGPPPAEEKRLLVVDLGCGKGGDLGKWQLAPQPVELYVGLDPAEVSIVQARERYNSMKSGRGNRGRRNPLFHGEFAPKDCFGEWLGDIGIVQQVGIDPNAGPGGSVMSSRWGGGGFDVVASMFAIHYAFESEEKARQMLRNVAGCLKKGGRFLGVCPNSDIISARVVELNAKRKAREEQEKKEKSDEAPEDGEVEEDTKLEWGNSIYRVQFPGKTPEDGIFRPPFGWKYSYFMEEAVEEVPEYVVPWEAFRALTEDYNLELQYRKPFLGIWGDEKDDRELGPLSERMGVRDRNTGELLMTEEEKEAANFYHAFCFYKV
What is the function of this protein?
Responsible for methylating the 5'-cap structure of mRNAs.
What are the official names of this protein?
mRNA cap guanine-N7 methyltransferase, mRNA (guanine-N(7))-methyltransferase, mRNA cap methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: XERC_PSESM
Sequence: MEQHLDAYCMHLRSERQVSPHTLEAYRRDLSKVLAYCQKARLSSWNDLDIQHLRSFTARQHQQGQSSRSLARMLSAVRGFYKYLNREGLCQHDPANGLSPPKGERRLPKTLDTDRTAQLLDGGVEDDFLAHRDQAIMELLYSSGLRLSELTGLNLDQLDLRDGLVQVLGKGSKTRVLPVGSKARQALETWLPLRALTNPQDDAVFVSQQGKRLGPRAVQLRIKTAGERELGQNLHPHMLRHSFASHLLESSQDLRAVQELLGHADIKTTQIYTHLDFQHLATVYDSAHPRAKRKGAADD
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU214_MOUSE
Sequence: MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSVLTISNKYGMLFAGGTNGLNVFPTKSLLIQNKPGDDPNKIVDTIQGLNVPMKFPVHHLALSCDSLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFTYHKVSNDASGMVNDMKWNPTVPSMVAVCLADGSISVLQVTDVVKVCATLPPSTGVTCVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFTIVYAGADGTLETCPDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQNDQTNWESWLLEDSSRAELPVTDKSDDSLPMGVAIDYTNEVEVTINEEKTLPPAPVLLLLSTDGVLCPFYMINQNPGVRSLIKTLELISTEGERQPKSSGSFPGTPSSPQAPQNLDAPATASSPLPPVSAAPTSTFPMPSAAGSPSVFSFGPSSFKSSASVTGEPPLYPTGSDSSRAAPGSGTSTFSFAPPSKGSLASTPAVAPVATSAAPFTFGFKPTLESTPMSSTPNTGMKPSFPPSASSVKVNLNEKFTAVASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLKSSVSPSPAAGRSTQTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQPPVTEKQRPQWKDSDPVLAGIGEEIAHFQKELEELKARTAKACLQVGTSEEMKMLRTESDDLHTFLFEIRETTESLHGDISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDRHLEQKKRQRRLIVPERETLFNTLANNREIINQQRKRLNQLVDSLQQLRLYNHTAPWSLPSALSTQSNSHSFDSDLECLLKTTIESHTKPSPRVPGKLSPAKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEGSSASSVAQPLEGEDARPTCTSVAQPLEGEDAQPICKEEEAVVPVPRHAPVVRTPSIQPSLLPQSMPFAKPHLIHSSSPAVMSSAVSTSATKVIPQGADSTMLATKTVKHGAPGPSHTVAAPQAAAAAALRRQMASQAPAMSTLTESTLKTVPQVVNVQELRSNPSPPSAAMGSAVQHSAAKTPHAVLTPVANSQAKQGSLINSFKPSGPTAASCQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPGAGPPTKEPTQLEAFSFGGGGKPFSEAIPGNSPATGATSAPSTSVTAASLEDSAPSSSKPAAPPETTVSSASSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAEDSTKPVSKASSTNLAGAQPAKPSGVSFPNTSVLGKPVEPAVTSSVSPAPAAPASALNVSTSSSSATVFGSVPLTSAGPPGLISFGGAALASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSFGGLLSSPSASSLPVSSGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASFVASTESMPVTLGAPDSKIEAVSPASTFAGPGQAAVATAVLPGAGSAATEASGTPTTSTVSSSSPTSATETAVFGTATSGSSVFTQPPAASSSSAFSQLSSNTATAPSATPVFGQVAASITSTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQTPAFGQATSSPASGFSFSQPGFSSVPAFGQSVSSTPASTSANVFGATSSTSSPGSFSFGQASTNTGGTLFGQNNPPAFGQSPGFGQGSSVFGGTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAANTGGSVFGQSSTSSGGVFGSGNATRGGGFFSGLGGKPSQDAANKNPFSSAGGGFGSTAAPNTSNLFGNSGAKTFGGFGSSSFGEQKPAGTFSSGGGSVASQGFGFSTPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSGNTASFGTLASQNAPTFGSLSQQTSGFGTPSSGFAGFGSGTGAFTFGSSNSSVQGFGGWRS
What is the function of this protein?
Part of the nuclear pore complex.  Has a critical role in nucleocytoplasmic transport.  May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
What are the official names of this protein?
Nuclear pore complex protein Nup214, 214 kDa nucleoporin, Nucleoporin Nup214.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Note=Cytoplasmic side of the nuclear pore complex.
Protein: LPXD_LEPBA
Sequence: MTQIKLSTLQTLLPDATFQNSETLKDINFSGLTSLTLAGPSDISFVASKTFVNEAKASKASLLVVSQETAEALSDKAIIIVSKVELTTAKIIRLFFPEKQPSGKRSAQVAIDPSAKIGSNTDIGHFVTIGKDSIIGNDCIIEDGVKIGDRVQIGDGARIGKNCVFFDDTIVGKRFIAFGNSTFGGDGFGFVYAEGKHNKIPQVGRVVIGDDVEVGSNCTIDRGALTDTTIGNGCKFDNMVHVAHNCKVGDHVIIAGQSGLAGSVTLGNNVIIGGACAISDHLTLVDGTIIAGGSSLRTSPKTKDVYVGWDLGLTFPEFQKYRVNIKNIVNLNKWLKRIENIEKKVGIETKES
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: RS3_SALEP
Sequence: MGQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQYLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEKPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: Y516_METST
Sequence: MKIEYFGHSAFKIVSEEGLIMLIDPFISNNPLCSTPVETIDADVILITHGHSDHFGDALEIANNSGATIIATAEIANFVQRQGINAIAMNIGGTVSINNLVNVTMTDARHTSSIDFTEEVEEGGSATGFVITLESGKKIYHAGDTGLFGDMKTVIGDIYKPDIALIPIGDKYTMGIEDAAIAAKWLQSRIVIPMHYNTFPGIEQDVELFAKNVEDEIIGTMTVPLMPGEDYREE
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Msp_0516.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: TRPD_STRTD
Sequence: MKEIFLQISNRQDLSQDQVQAVFDRILKNEVSESQIASFLMGLKIKGETSDEITGIVRALKSHATVLPETFTDAMCNCGTGGDQSYSFNISTTACFVLAAGGIRMAKAGNRSISSKSGSADVLEVLGINVAASPEILSKALDEVGLAFIFAQTMHPAMRFIGPARQALGIPTIMNLVGPLANPLDLETQLMGLYRVELQEIVANAIQQLGRKRAVIITGPDNMDEAALYGTNTYTLLEDGHISQHTFTYEDLGMEKVELSDITGGDAKENAEILLSVLRNEASPYLETTVLNVGLGFFANGKAGTIKEGVELARQLIADGSALEKLRKLQEVQV
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: Y700_METJA
Sequence: MIDNKLKLVIKVVLLIFLLHSLMSIFNLETYIKILAKYQNQIMIIAIIILSGLIIVDIASEVFKKYARTREEKAGEYLTLNYIFKYLVYVCVTLMIFGVIYQNVSSLVVSVGLIGAAVTYALQKPILNFAGWIIILYTRTIKIGDRIFIKNMGAGDVFDIDTQHIYLSELTTDTFEPTGRVLIIPNSYIFTASIENLTKGSPYIWDNIVVHFTLNSNINKAEKIVFESADEVIGNLMRELYEKWSKRKYLISRKLSDKPVVRVGITRSSFYIKALYLVNVYEKAKIRSEINKRILEKVNKENDVKLAYPHIKAVIETENKFKNT
What are the official names of this protein?
Uncharacterized MscS family protein MJ0700.
What is the protein family that this protein belongs to?
Belongs to the MscS (TC 1.A.23) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FTHS_HALOH
Sequence: MKSDIEIAQDARMEPIEEIAEKAGLHKDQIELYGKYKAKVNTDIIDDDKKDGKLVLVTAITPTPAGEGKTTTTVGLGQALNLLGKKAIIALREPSLGPTMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAIGAAHNLLSAVIDNHIKQGNDLGIDPTSVTWKRVVDMNDRALRNIVVGLGGKAHGVPREDGFMITVASEIMAILCLANNLEDLKNKISNIVVGYTYDGEAITAGDLKVSGAMTALLKDAIKPNLVQTLENTPAFIHGGPFANIAHGCNSIMATKMALKLGEITVTEAGFGADLGAEKFFNIKCRYAGLNPDAAVVVATVRALKMHGGVDKDSLSEENLDALARGFENLEKHLENVSKFGVPSVVAINRFPGDTEAELNLVRDKCEEMGVPVAISEVWARGGEGGLDLARKLVDVLENTPGQFSYLYDVNFPITDKIEKIAKEIYGADGVNYTSKALKQIDKYTELGYDKLPICMAKTQSSISDDPSLKGRPRGFRINVREVNLSAGAGFIIPLTGPVLTMPGLPKKPAAEGIDIDADGKISGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: ATF_ASPTN
Sequence: MFATFNSSMDNRSSANSPVAPSSRPKRTTVARACDWCRLNRVKCDDGQPCKNCRTRGVRCRKGSKSGEHNRPSSSAAASERARSQGAQMEPNQGNARAEEREKAATTSRRNSRTPSSSPSSPSPSQWRWPGAWIVDSVHTNSEPRYYGPSSFLHFTNRLRIYLDESLGQPQLGNALLSFTCSRVSSPSPNAMDDADLTEGTLTRQQEEYLLSLYWQSYHTIIPIVDADDFCAHYRSLWEPGQGATRRPSALVDIVLALCMQYSAALMASGDIELMDLESNDTNASGHWLYQRCQRLLLKDQDTLSLATLQTYIHSAVYLMNASCLNASHRVLSIAIHTATSLGLPHSPEGHPRGPQHALRQRIWWTLFFLDSKMSFELGQPYLMPEYHGTVDLSGSLELRIIENCRSVSTFGDITWLRYHDECLKLTSKVRHISNVAFEKSSEAMSRHSGTSIYENPSALEKGVSYLHKSMEALQAWSREVPTSLKLARKGNVSPFSTARCPLENDVYAPLWLQRQRVLLELLYHNLVMGLYRPYIRVADQSAVTSHAIGPTASHTSDSSSLCALNHAMATINIVYQVLTETDILNSWNRAFQYTWDATLTVLGFRLVHPGCPHSFSARRATAIANESFKIFSQYGYSGAAQAMTVTRELDRSIDLAVSREPG
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase (PubMed:25265334).
What are the official names of this protein?
Terreic acid cluster-specific transcription factor atF, Terreic acid biosynthesis cluster protein R.
What are the subcellular locations of this protein?
Nucleus.
Protein: PAT2_CAEEL
Sequence: MREGSFPRRIGLLLGLLGLLAGVATFNIDTKNVVVHHMAGNYFGYSLDFYHEQKGMPVLVVGAPEAESNNPNLAGIRRPGAVYACSVNRATCREVHVDKMKGNLKKLNGSHLVPIEEKSHQFFGATVRSNDKHDKIVVCAPKYTYFYSKFEVIEPVGTCFYAENGFDNAEEFSSCKQEPARHGRHRLGYGQCGFSAAVPGKKNQNRVFIGAPGVWYWQGAMFSQNIKNQTDRPNTEYGSKEYDHDMMGYSTATGDFDGDGIDDIVAGVPRGNDLHGKLVLYTSKLKMMINLTDEVSTQHGQYCGGSVAVADVNKDGRDDIIMGCPFYTDYGSVKDAKTQERKPQYDVGKVIVMLQTAPGVFGKQIAVVGDDQWGRFGHAVAAAGDLNLDGYNDVIVGAPYAGKNKQGAVYVIHGSKDGVRELPTQKIEGANIGHGNIKSFGFSLTGNEDVDGNGMPDIAVGAWKSGNAAVLLTKPVVTVTGQTEPESALISVEDKNCDVDGKLGKQACKHINTCFKYEGKGDTPNDLEFDLRFNLDDHSPEPRAYFLQKDVKSDRSIKVAQGSKTRDHPSSIEQRVRLEKGRQKCFRHRFFASSTMKDKLSPIHWSVNYTYVESKTGKLRGDKLEPAIDTTVPLSFQNKINIANNCGKDDLCVPDLKVTAVADREKFLLGTQDNTMLINVTVQNGGEDSYETKLYFDVPQGFEYGGIESVGGDGSKSAPACSPTSDEPDSDGKWTFACDLGNPLPANKVVSSVVRVTASSDKPPLAPISINAHVNSSNDEEAHTVADNKVTFTIPVDFKNQLSLNGRSNPEQVDFSMTNKTRVDAFDDNEIGPVVSHLYQISNRGPSEVDSATLDIFWPSFSTEGGHLLYIITEPVVNPPNKGRCRVKQLQNVNPLNLRITNEHVPTEPPVAKTPNEYSREEDDESYEDETTTQSQSTRHQSTQHQTHHQSGPVHVYEKDEEKIRQNTGNWQYVEDKKKKGDYEYIPDDQEYDGDDFEEEDDEDFDRAGSKRVKRNPTPKKKKKGGEHRGEPRSDKARFSDLREAVKLSKEAGGVVDYKGPLSRASVDCNSLRCTHIECDIYDLKEDEFVLVEIFSRLYTNTLVDEKNPGGDISSLALARVTSTKYNLPHKPTLITAVSTNMNAIASEEGRDLPWWLYLLAILIGLAILILLILLLWRCGFFKRNRPPTEHAELRADRQPNAQYADSQSRYTSQDQYNQGRHGQML
What is the function of this protein?
Required for muscle development probably through the regulation of the actin-myosin cytoskeleton (PubMed:8106547, PubMed:12915588).  Component of an integrin containing attachment complex, which is required for muscle maintenance (PubMed:22253611).  During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52 (PubMed:16495308).  Required for distal tip cell migration and dorsal pathfinding (PubMed:17606640).  Required for egg-laying (PubMed:12915588).  May play a role in cell motility and cell-cell interactions (By similarity).  Plays a role in vulval development (PubMed:28135265).  Probably within the alpha pat-2/beta pat-3 integrin receptor complex, plays a role in the negative regulation of let-23 signaling and vulval induction.  This is probably partly by restricting the mobility of the let-23 receptor on the plasma membrane of vulval cells which thereby attenuates let-23 signaling (PubMed:28135265).
What are the official names of this protein?
Integrin alpha pat-2, Paralyzed arrest at two-fold protein 2.
What is the protein family that this protein belongs to?
Belongs to the integrin alpha chain family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RNAS1_NOTRU
Sequence: ETAAEKFQRQHMDTEHSTASSSNYCNLMMKAREMTSDRCKPVNTFIHEPKSVVDAVCXQENVTCKNGQTNCYKSNSRLSITNCRQTGASXYPNCQYETSNLQKQIIVACEGQYVPVHFDAYV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: MALD_MALAU
Sequence: MDTGKRLVTVFGGTGNQGSSVVRSLLAHKDKLFHVRVITRDPTSEKAQACAKLGAELVKADGFNKSETVSAFMGSWGAFVNTNSDEEIYKIPGGRSDYDLGSTVLDATKEAGVKHVVYSSGLNLCKYTNGRVHSEGFESKYYVEQYGRRKGFQTFTPIVPASFMEAFLAESFCQSLGGFPWFKRDTGEYLLATPPYGGDERMPWVSVEDDFGDIVHGIFLDPDSYHLKTIQGSSELISFEKMVEDFMEVTGEKARYVRLKSWVDIPLDGTSCREEMRAIFHSMYSNGGKWFVPDESEIDTATTLKKEAKLAQGVTDGSLTAFKDWIHKQWERRLPN
What is the function of this protein?
NmrA-like family domain-containing oxidoreductase; part of the gene cluster that mediates the biosynthesis of malbrancheamide, a dichlorinated fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2. 2. 2]diazaoctane core (PubMed:23213353, PubMed:31548667, PubMed:28777910).  The first step of malbrancheamide biosynthesis involves coupling of L-proline and L-tryptophan by malG, a bimodular NRPS, to produce L-Pro-L-Trp aldehyde through reductive offloading (PubMed:23213353, PubMed:31548667).  This compound undergoes spontaneous cyclization and dehydration to give a dienamine which is reverse prenylated at C-2 by malE (PubMed:31548667).  The other prenyltransferase present in the cluster, malB, displays modest activity, suggesting that may be a redundant gene in the pathway (PubMed:31548667).  Subsequently, a [4+2] Diels-Alder cyclo-addition catalyzed by the bifunctional enzyme malC forms the characteristic bicyclo[2. 2. 2]diazaoctane ring of premalbrancheamid (PubMed:31548667).  Finally, the flavin-dependent halogenase malA catalyzes the iterative dichlorination of the indole ring of premalbrancheamide to yield C-9 monochlorinated malbrancheamide B, C-8 monochlorinated isomalbrancheamide B, and dichlorinated malbrancheamide (PubMed:31548667, PubMed:28777910).  MalA is also able to brominate premalbrancheamide at C-9 to yield malbrancheamide C, and, to a lesser extend, at C-8 to yield isomalbrancheamide C (PubMed:28777910).  Finally, malA can brominate C-9 monochlorinated malbrancheamide B at C-8 to yield malbrancheamide D, or C-8 monochlorinated isomalbrancheamide B at C-9 to produce isomalbrancheamide D (PubMed:28777910).
What are the official names of this protein?
NmrA-like family domain-containing oxidoreductase malD, Malbrancheamide biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family.
Protein: Y059_ACIF2
Sequence: MSGHSKWSTIKFKKALKDAKRGKIFTRLIREITVAARAGGGDPASNSRLRLALDKAYGANMTKDTIERAIKRGTGELEGVDYEEVTYEGYGPGGVAILIETMTDNKVRTVAEVRHIFSKRGGNMGTAGSVAYQFKKLGLIVFPADADEDRILEAALEAGAEDVVNEGERIAVYTAPSDLHSVVLALEAAGLKPEESEMTMIPENTIEVSGEEAEKLLRLIDFLEENDDVQNVYANYDISDEEMARLEATS
What are the official names of this protein?
Probable transcriptional regulatory protein AFE_0059.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLA1_PYRHO
Sequence: MTVVPRKGAVGIGTLIVFIAMVLVAAVAAAVLINTSGYLQQKASGTGRETTQEVASGIKVDRVVGYAPDITGDITRLAVYISPNAGSSGIDLNKVRVILSNGQKEVSLKYNYVYNATSSTQTYVALPQGNIFNDIVLGVNGTSENAASTQVNFNWSLLTGSTFGLIVLQDADGSVKASTPTLNQGDLVIIAIDVDAALGGIPPRTSITGEVIPEQGAPGVIEFTTPSTYTAHVMELQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
What are the official names of this protein?
Probable flagellin PH0546.
What is the protein family that this protein belongs to?
Belongs to the archaeal flagellin family.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: PLSY_STRMU
Sequence: MKLILLIIAAYLLGSIPTGLWIGKYFYGKNLRDYGSGNMGTTNTFRVLGPKAGLLTFTVDFLKGTLATLLPMWLGVTHISPLLFGFFAILGHTFPIFANFKGGKAVATSAGILLGFAPFYLIFLLFIFFFTLYLTSMISLSSVIAASIAIITVLIFPALHFLLKDYDFLFVLIVISAGSLIIIRHRENLVRIKNKTESLVPFGLNITKQKTH
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYA_LACDA
Sequence: MKKLNSSEFRQMFLDFFAEHGHMVMQSASLIPKDDPTLLWINSGVATMKKYFDGSVVPKNRRITSSQKSIRTNDIENVGKTARHQTLFEMLGNFSVGDYFKEEAIPWAWEFLTSPDWLDLDKDKLYVTVYPKDTEAHRIWHEVVGLPESHIVQLEDNFWDIGEGPCGPDSEIFYDRGQENNDVPEDDPENYPGGENARYLEIWNIVFSEFNHLPDGSYVEQPHKNIDTGMGLERVLSILQDAPTNFETDLFLPIIHATEEMSAGKKYGANKADDISFKIIADHIRAISFAIGDGALPGNTGRGYVLRRLLRRAALNGRKLGIDGAFLYKLVPVVGDIMKSHYPEVSDQAEFISKVVKNEEDRFGATLEAGLTLLDDLIDKAENSEDKTISGKDAFKMFDTYGFPYELTVEAAEDKGLKVDKDGFDAEMEAQKERARKARGNLQSMGSQDETLMKIKDKSVFEYGVYEEESQLVDIIVDDKLVDKADGEKATLIFDKTPFYAERGGQVADHGDIYDQEGNLVARVVDVQHAPNDQNLHFVDVVLPLVKGQTYKLKIDRARREGLRHSHSATHLLHAALRQVLGEHTHQAGSVVEPDYLRFDFTSLDPITPRELKNVEKIVNEKIWEAIQVKTTETDPETGKKMGALALFDGKYTDKVRVVQMDDFSIEFCGGTHCDNTSQIGVFKIISEQAIGAGVRRIEAVTSKLAYEYLAGRSDILDQIQAQVKATKVDGIQSKIASLQEELRSAEKQNAAYEAQINASKAGKIFDQVKTVGDLTVIATIADVKGMNDLREIADQWKSEGKSDVLILGAKSEDKANMLISLGQKALDKGLKAGDLIKSVAAIFGGGGGGRPNMAQAGGKNPEGLQDAIDAAVSQLD
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA1C_ODOVE
Sequence: MFTMKKSLLLLFFLGTISLSLCEEERGADEEEGDGEKLTKRALSILRGLEKLAKMGIALTNCKATKKC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Palustrin-1c, pal1c.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: THIG_SALTI
Sequence: MLRIADKTFDSHLFTGTGKFASSQLMVEAIRASGSQLVTLAMKRVDLRQHNDAILAPLIEAGVTLLPNTSGAKTAEEAIFAAQLALEALGTHWLKLEIHPDARWLLPDPIETLKAAEALVKQGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLETKAMLEIIIQQATVPVVVDAGIGVPSHAAQALEMGADAVLVNTAIAVADDPVMMATAFRLAVEAGLLARQAVPGNRSTYASATSPLTGFLEALA
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIHX_SHIFL
Sequence: MLYIFDLGNVIVDIDFNRVLGAWSDLTRIPLASLKKSFHMGEAFHQHERGEISDEAFAEALCHEMALPLSYEQFSHGWQAVFVALRPEVIAIMHKLREQGHRVVVLSNTNRLHTTFWPEEYPEIRDAADHIYLSQDLGMRKPEARIYQHVLQAEGFSPSDTVFFDDNADNIEGANQLGITSILVKDKTTIPDYFAKVLC
What is the function of this protein?
Catalyzes the dephosphorylation of alpha-D-glucose 1-phosphate (Glc1P) and, to a lesser extent, of other sugar phosphates.
What are the official names of this protein?
Alpha-D-glucose-1-phosphate phosphatase YihX, Alpha-D-glucose-1-P phosphatase, Alpha-D-glucose-1-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. YihX family.
Protein: PSIN_DICDI
Sequence: MGNINKKLFYFLIQLITILIVLSDDSYNSLLPLEKDIAVIIRDLSPQTNPDFEIDNPNRVIKGLVKDQLNEEDRSPIYCCGDDHAPNIDRNRFVIHNQSTFYSWFHNQKDVNIVISKSLVFTRNVTSDDPRIYSYESDNFFPIDKMGFEADSYNGPIKKNQWKDRWGFPRNFHFCLELHASFFYIGGELFSFKGDDDVWVFIDNRLVLDLGAPHDVSGQNGQGSVYLDNLGLEKSKSYNFDFFYCERHTTDSHIMVETSIDFKCKYYDYCGVCEGMGKCCNPSECYGSLPACGHFECPGLTDIAPNVDWRYHCKVVVPNCSLSDTFCVKHQCDPDSKQCVPSTDYQPCQGKSNSSCIEARCDDKMGGCYLKSKPKDQSKNDTTCYRETCNEDTSTWEYKALCEDDSDKCISKKCIPNSGCSSSVVDCNDNNHCTIDSCSKDTGCIHDPIENCVPCVEGNKCSESSDKCQQLECNPYNSTTECIDRTKKNCDDSNACTIDTCNGESGECENTPKQCLAKNKCSTARCNSKTGQCDNIYHCDDGILCTLDKCSENGTCYYEANPCDDGDQCTIDICLNTLTETGGCSHSARVCEPKNSCFTSHCDKKLGCVQTPIECPVEAFCLISFCDNSTKKCMTADRPCIPDDPRCQYGVCDNDTKACIFKDYDPLPFKCQSAAVKAAVGVGAGAAAGIAIGGAIALGLAAFGGKRGYDAWKSSRDNQIQTSSENPLYNPNPNQGDNPLYAANNS
What are the official names of this protein?
Protein psiN.
What is the protein family that this protein belongs to?
Belongs to the prespore-cell-inducing factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.