PharMolix/UniProtQA huggingface dataset:
Protein: Y3200_CHLAD
Sequence: MNQRQLMQMAQQMQRQMQKVQEELAATIVEGTAGGGAIVVKMNGHREVQSITISPEVVDPNDVDMLQDLLLVAINDASRKAQQLAEERMQPLTGGLKGLF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Cagg_3200.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CTU1_DROPE
Sequence: MPINCKAKCGKAAALKRPKTGDALCKECFFAAFEAEIHHTITSSKLFRRGEKVAVAASGGKDSTVLAHVMKLLNERHDYGLELVLLSIDEGITGYRDDSLETVKQNRDDYKMPLKILSYEELYGWTMDRIVSQIGRSNNCTFCGVFRRQALDRGARLLCVDSIATGHNADDIAETVLMNVLRGDTARLRRCTDIRTGGGEDSIPRVKPLKYSYEKEIVMYAHYKKLVYFSTECVFAPNAYRGHARAFLKDLEKVRPSVIMDIIYSGEQLRFKDTAKNPVRGTCNRCGFISSQQPCKACVLLEGLNRGLPKLGIGKKSKGDRMIAKQDQELALRERANLVKNDF
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_ERWT9
Sequence: MNVIEAAVATPDARVALVIARFNNFINDSLLSGALDALKRIGQVKDENITVVWVPGAYELPVTARALAKTGKHDAVVALGTVIRGGTAHFEFVAGEASSGLASVAMHSDIPVAFGVLTTENIEQAIERAGTKAGNKGAEAALTALEMINVLKAINA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: GBPA_YERE8
Sequence: MKLNKIMLAMVVMSISGTAMAHGYIENPPSRNFLCNAQGGSLNKDCGGVQYEPQSSGETADGFPQQGPVDGKLASGDNWVSVNLNQQTAERWTKVKMKAGPQEFKWKFTAAHPIADFKYYMTKQDWNPNQPLTRDSLDLTPFCVIPGGPASTTGSTTHTCNIPERTGYQVIYGAWDVSDTPGTFYNMIDAEFDGATGEVVVSEWTKSIGNIEPHDDLNAGDTVKLRMFDQQGERSDLVVEITIADAKEGKKNNWSHALASKLNNTHQDIRAGKKDSKGTVTATHGANAIFINANSNILRAEVQIEKSPAGEVSATDASFSANGMKKEYQMADGALAIHFDVKTMGSMDLEAKVFAADNSVKGYKDMTLEDASQHVSIAMTGLKAGKHTLVILGTDAQGKTQQQSIDFMVKGETVKPEVKPEVKPEVDGANKQCTAPAWSNKSSYQAKDTVTHNGRIYMSKWWADKASVPGDAAVTDTTGNGSGWGKVWEDKGAC
What is the function of this protein?
Probably interacts with GlcNAc residues.  May promote attachment to both epithelial cell surfaces and chitin.
What are the official names of this protein?
GlcNAc-binding protein A.
What is the protein family that this protein belongs to?
Belongs to the GbpA family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS6_BURM7
Sequence: MALAKRIIPCFDVTAGRVVKGVNFVELRDAGDPVEIARRYDAQGADELTFLDITATSDGRDLILPIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVSMNSSAVANPPLVRDAADKYGSQCIVVAIDAKRVSADGEPPRWEVFTHGGRKGTGLDAVEWARKMAELGAGEILLTSMDRDGTKAGFDLALTRAVSDAVPVPVIASGGVGSLEHLAAGITEGHADAVLAASIFHYGEHTVGEAKRFMAERGIAVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFMA_ECO57
Sequence: MKLRFISSALAAALFAATGSYAAVVDGGTIHFEGELVNAACSVNTDSADQVVTLGQYRTDIFNAVGNTSALIPFTIQLNDCDPVVAANAAVAFSGQADAINDNLLAIASSTNTTTATGVGIEILDNTSAILKPDGNSFSTNQNLIPGTNVLHFSARYKGTGTSASAGQANADATFIMRYE
What are the official names of this protein?
Uncharacterized fimbrial-like protein SfmA, Type-1A pilin.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: NUOA_ECOL5
Sequence: MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARSKNVPFESGIDSVGSARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLVRIGALDWTPARSRRERMNPETNSIANRQR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CHIGU_GLUUR
Sequence: ADGTITFNGKVTDK
What is the function of this protein?
Has endochitinase activity.
What are the official names of this protein?
Endochitinase.
Protein: HOLIN_BPB03
Sequence: MMNMIEWTKHVLESDDTKLIYWLTLLMVCMIVDTILGIVIARINPKEKFSSFKMKTGILIKVSEMIIALLAVPFALPFPAGLPLLYTVYTALCVSEMYSIFGHLRVVDDKSNFLSIIEGFFKQTYRKDKGDK
What is the function of this protein?
Counteracts the aggregation of the holin molecules and thus of pore formation.
What are the official names of this protein?
Antiholin, Gene product 14, gp14, Protein p14.
What is the protein family that this protein belongs to?
Belongs to the bacteriophage holin family. phi29likevirus holin subfamily.
What are the subcellular locations of this protein?
Host cell inner membrane; Multi-pass membrane protein. Note=Classified as a class I holin.
Protein: RL5_SHEPC
Sequence: MAKLHDKYQETVVAELAKKFGYTSVMQVPRIEKITLNMGVGEAVADKKVMEHALRDMTAIAGQKPVVTVARKSVAGFKIREGYPIGCKVTLRGERMWEFLERLVDIAIPRIRDFRGLSAKAFDGRGNYAMGVREQIIFPEIDYDKIDKIRGMDIVITTSAKTDEEGRALLDAFNFPFKK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: COAE_GEOSL
Sequence: MNIIGLTGGIASGKSTVSRILERLGAVVIDADQLAREAVMPGTSAHRSIVAAFGEGILLPDGAIDRKALGSIIFADSSARKRLEAITHPAIRDLAELRLAELRRSGVPVAVYMAALLIEAGATDRVDEVWVVYVDRETQVRRVMARDGLSRSEAEQRLAAQMPMEEKAARGQVVIDNNGTPEELERRIEEIWAKRFP
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETD_SPIOL
Sequence: MGVTKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMASVPAGLLTVPFLENVNKFQNPFRRPVATTVFLVGTVVALWLGIGATLPIDKSLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: UVRC_GEOMG
Sequence: MFDKSRLNTLPESPGVYLMKGSDGTILYVGKAKSLRKRVRSYFGAAGESRYHIRFLVARVAEVEVIVTDTEKEALILENTLIKKHRPRYNLDLRDDKTYFSLRMDMNEEFPRLTIIRKVRQDGARYFGPYSSAASAREALKQLYRLFPLRHYPLETCRRRRRPCLFYQLRQCSAPCHGLISPEEYQGLVQGAALFLDGKNRDLLKTYRERMASAAANERYEEAARYRDLIRAIEVTVEKQKMVTTGGDADVLGIHREGSSLSLALLFIRGGRLIGSRSYLLAWELEDEEAVSSFLNDYYSREVFIPDEVLVPLPVADSAALAELLSERRGKRTSVAHPQRGTKAGLVKLAGKNAEAALREKQKREEGAEAVLTELKERLHLRNLPRCIECYDISNIQGTYPVGSRVSFRDGKADKGGYRHYRIKTVAGADDFAMMHEVLSRRFRDSPAKDEHPDLIVVDGGIGQLNILTAVLRELQVEDVDAASLAKSRVERDMAAEELTRSTERVFLPGRKNPVILRQNSAPLLLLARIRDEAHRFAITYHQKLRGKDTIRSILDTIPGIGPKRRKELLRQFGSLRRIREASRDELAATPTIPPTLAESIWKSLHENDEGDTP
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_PECCP
Sequence: MVKVYAPASIGNVSVGFDVLGAAVSPVDGSLLGDCVSVEAADLFSLRNEGRFVSKLPDNPKENIVYQCWELFCQEIGKTVPVAMTLEKNMPIGSGLGSSACSVVAGLMAMNEFCGKPLDDTRLLTLMGELEGRISGSVHYDNVAPCFLGGVQLMLEENGIISQPVPSFDDWLWVMAYPGIKVSTAEARAILPAQYRRQDCISHGRYLAGFIHACHTGQAALAAKLMKDVIAEPYRTKLLPGFAAARQAAEDIGALACGISGSGPTLFSVCNDMTSAQRLADWLRDNYLQNDEGFVHICRLDTTGARQLG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_ANOFW
Sequence: MSIPKELRYSQEHEWVRVEGNTVRIGITDFAQSELGDIVFVELPEVGAQLTANEPFGSVESVKTVSELYAPISGKVVAVNEELNDNPEYVNESPYDKAWMIVIEPSDLSEVDNLLTAEQYEQMINQD
What is the function of this protein?
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
What are the official names of this protein?
Glycine cleavage system H protein, Octanoyl/lipoyl carrier protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: MKRN1_HUMAN
Sequence: MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL
What is the function of this protein?
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.  These substrates include FILIP1, p53/TP53, CDKN1A and TERT.  Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions.  Acts as a negative regulator of telomerase.  Has negative and positive effects on RNA polymerase II-dependent transcription.
What are the official names of this protein?
E3 ubiquitin-protein ligase makorin-1, RING finger protein 61, RING-type E3 ubiquitin transferase makorin-1.
Protein: CT54A_CONTE
Sequence: MHCLPVFVILLLLTASGLSVDARPKTEDDVPLSSFRDNTKSTLQRLLKRVNCCPIDESCCS
What are the official names of this protein?
Conotoxin TeAr154.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
Protein: SPNS2_ARATH
Sequence: MDVDGEGDRGQNPRIMERDSDSIKDPISEPSWFTPKKLLFVFCVVNLINYIDRGAIASNGINGSRGSCTSSGTCSSGSGIQGDFNLSNFEDGVLSSAFMVGLLVASPIFASLAKSVNPFRLIGVGLSIWTLAVIGCGLSFDFWSITICRMFVGVGEASFVSLAAPFIDDNAPHDQKSAWLAVFYMCIPTGYAFGYVYGGVVGSVLPWRAAFWGEAILMLPFAVLGFVIKPLHLKGFAPDDTGKPRTDNLNVLPVGYGFSAVMKDLKLLLVDKVYVTNILGYIAYNFVLGAYSYWGPKAGYNIYKMENADMIFGGVTVVCGIVGTLSGGVILDYMDATISNAFKVLSVSTFIGAIFCFAAFCFKSMYAFLALFAVGELLVFATQGPVNFIVLHCVKPSLRPLAMAMSTVSIHIFGDVPSSPLVGVLQDYVNNWRVTSLVLTFVLFPAAAIWSIGIFLNSVDRYNEDSEPDAVTRESTAAPLLQEA
What is the function of this protein?
Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage.
What are the official names of this protein?
Probable sphingolipid transporter spinster homolog 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein.
Protein: YOAH_SALAR
Sequence: MFAGLPSLSHEQQQKAVERIQELMSQGMSSGEAIAQVAGELRANHTGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: RL15_SHEB2
Sequence: MRLNTLSPAAGSKHAPKRVGRGMGSGLGKTAGRGHKGQKSRSGGGVRPGFEGGQMPLKIRLPKFGFTSRRAMVTAEVRVLELAKVNGDVIDLNALKDANVITRNIQFAKIVLSGTIERPVTVKGLKVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ILVD_RHIE6
Sequence: MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLHGKTHALDLVDAMVAAADDKISDEDVKVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIVDLARRYYEQDDVKALPRTIASKQAFENAMALDIAMGGSTNTVLHILAAAHEGEVDFTMADIDALSRRVPCLSKVAPAKSDVHMEDVHRAGGIMSILGELDKGGLLNRDCPTVHAETLGDAIDRWDITRTNSDTVRNFYRAAPGGIPTQVAFSQEARWDDLDTDRQNGVIRSVEHPFSKDGGLAVLKGNLAIDGCIVKTAGVDESILKFSGPARVFESQDGSVKAILANEVKAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAANGGTIGLVREGDMIDIDIPNRTISLRVSEAELADRRAEQDGKGWHPTEVRKRNVTTALKAYAAFATSADRGAVRDLNAR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: HYBF_MORMO
Sequence: MHELSLCMSAADIIREQAEQHGIARVTDVWLEVGALADVEESALHFCFDIACRDTVAQGCTLHIDVIPAQAWCWDCSREAEIMQHAGCCPHCGSERLRISEGDDLRVKSLEGE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HybF.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family. HybF subfamily.
Protein: ATPD_ACIFI
Sequence: MADLITVARPYAEALMGWRKRAARNRPGRMHCRRLPAMIADVQAQAFLTDPERRDAEKVSLLSAVPVAVDVKAWKAFLALLIHNDRWPATAEIGTLFADAMRRAEGVVDVLVTSAIALDAGQKTAVQSALERRFAGHKVRFREAVDAALIGGLVIHTGDLTIDASVRGQVQQLARTLRS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NRAM_I18A0
Sequence: MNPNQKIITIGSICMVVGIISLILQIGNIISIWVSHSIQTGNQNHPETCNQSIITYENNTWVNQTYVNISNTNVVAGQDATSVILTGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRTLMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTIMTDGPSNGQASYKILKIEKGKVTKSIELNAPNYHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGANGIKGFSFRYDNGVWIGRTKSTSSRSGFEMIWDPNGWTETDSSFSVRQDIVAITDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGQPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFSIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: KDPB_SALG2
Sequence: MSRKQLALFEPVLLVQALTDAVKKLSPRAQWRNPVMFVVWAGSVLTTLLTLAMVTGQIAGGALFTGIISLWLWFTVLFANFAEALAEGRSKAQANSLKGVKKTAFARRLRAPRHDAQADNVPAAELRKGDIVLVKAGDIIPCDGEVIEGGASVDESAITGESAPVIRESGGDFASVTGGTRILSDWLVIACSVNPGETFLDRMIAMVEGAQRRKTPNEIALTILLIALTIVFLLATATLWPFSAWGGNAVSVTVLVALLVCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGDVDVLLLDKTGTITLGNRQASDFIPARGVDERTLADAAQLASLADETPEGRSIVILAKQRFNLRERDVQSLHATFVPFTAQSRMSGINIDNRMIRKGSVDAIRRHVESNGGHFPADVEQNVENVARLGATPLVVVEGARVLGVIALKDIVKGGIKERFAQLRKMGIKTVMITGDNRLTAAAIAAEAGVDDFLAEATPEAKLALIRQYQAEGRLVAMTGDGTNDAPALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLIEVVHIGKQMLMTRGSLTTFSIANDVAKYFAIIPAAFAATYPQLNALNVMGLHSPNSAILSAVIFNALIIIFLIPLALKGVSYKPLSASAMLRRNLWIYGLGGLVVPFIGIKVIDVLLTLLGLLGLA
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PO6F1_DANRE
Sequence: MDTEDLPANNAPLTVNEQLLGSCTLKFPAQDAQVIVMSGQETIRVLEVEVDTALSSAGAAESGGDEEGSGQSLEATEEAQLDGPVTTSSTTAVTVEVSAPVVQTVVSKAAISVSPAQQTSVPITVQACPQVLTQDGLASLMTGMLAQQSSLGQPLLIPLSMAGSVGGQGGLAVLTLPTATVATLPGLAAASPAGGLLKLPFAGLQAATVLNSVQTQLQAPAQAVLQPQMSALQAMQQTQTTAATTASIVQKASEPSVSVATLQTAGLSINPAIISAASLGAQPQFISSLTTTPIITSAMSNVAGLTSQLITNAQGQVIGTLPLLVNPASLAGAAAASALPAQGLQVQTVAPQLLLNSQGQIIATIGNGPTAAIPSTASVLPKATVPLTLTKTTTQGPVGKVAPSKVIIAPQPSVVKPVTSLTAAGVIACGEMPTVGQLVNKPSAVKDEEAINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLERWLAEAELWNQKGQQNLMEFVGGEPSKKRKRRTSFTPQAIEVLNTYFEKNSLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKINVFQSQ
What is the function of this protein?
Transcription factor that binds with high affinity to the motif 5'-TAATGARAT-3'.
What are the official names of this protein?
POU domain, class 6, transcription factor 1, POU domain protein C, POU[C], ZfPOU[C].
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-6 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS13_PSEAB
Sequence: MARIAGVNIPDNKHTVISLTYIYGVGRTTAQSICAATGVNPAAKIKDLSDEQIDQLRNEVAKITTEGDLRREINMNIKRLMDLGCYRGLRHRRGLPVRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RL14_ALKCK
Sequence: MIQQESRLKVADNSGAREVLCIKVLGGSGRKIANIGDVIVCSVKEATPGGVVKKGDVVKAVIVRSKSGVRRNDGSYIKFDENAAVIVRDDKSPRGTRIFGPVARELRDNQFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: CYC32_DESNO
Sequence: ETFEIPESVTMSPKQFEGYTPKKGDVTFNHASHMDIACQQCHHTVPDTYTIESCMTEGCHDNIKERTEISSVYRTFHTTKDSEKSCVGCHRELKRQGPSDAPLACNSCHVQ
What is the function of this protein?
Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin.
What are the official names of this protein?
Cytochrome c3, 26 kDa.
What are the subcellular locations of this protein?
Periplasm.