PharMolix/UniProtQA huggingface dataset:
Protein: G6PD3_ARATH
Sequence: MSSLSCPTYRSRTSSSSPFLSNHHHSSLINVVDPRRSLSFHYASPQGLNLAELCVVRSQRRSVQSSVVVQDGSVATESSSSEEAKDVGVLTIPSLEADKVVAESDGGEQLSTVSITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRVMVSKTLTCRIDKRANCGEKMEEFLKRCFYHSGQYDSQEHFVALDEKLKEHEGGRLSNRLFYLSIPPNIFVDAVKCASSSASSVNGWTRVIVEKPFGRDSKTSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIKLEDVVIGQYKSHSIGGVTYPSYTDDKTVPKGSLTPTFAAAALFIDNARWDGVPFLMKAGKALNTRSAEIRVQFRHVPGNLYNRNSGTDRDQTTNELVIRVQPDEAIYLKINNKVPGLGMRLDQSNLNLLYSARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKEIEEKKTTPEFYPYGSRGPVGAHYLAAKHKVQWGDLSLDQ
What is the function of this protein?
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis (PubMed:15634201).  The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division (PubMed:15634201).
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic, AtG6PD3, G6PDH3.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: CSPA_KLEPN
Sequence: SKGFGFISPKDGSKDVFVHFSAIQSDSFKTLNEGQEVSFTIENGAK
What are the official names of this protein?
Major cold shock protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_BURCM
Sequence: MTHTLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASAVKRYAVEHGMPVAQPPSLRRAGKYPAEAADAIELLRTTPHDVMVVAAYGLLLPQEVLDIPRAGCINIHASLLPRWRGAAPIHRAIEAGDAETGVTLMQMDVGLDTGAMIDEARVAIAPDDTTATLHDRLAADGARLIVDALVRLERDGALPATPQPADGVTYAEKIGKHEAALDWRKPADVLARQVRAFDPFPGGVATLDGAAIKLWAAEPVAARGDAAPGTIVDAAPEGVIVACGSGALRVTQLQKPGGKRLPAREFLAGSPLAAGQRFALPDGA
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: TACAN_XENLA
Sequence: MNSPVLQDCVREWGEIQENYQDIQETHRLYKQKLEELSKLQTRCSGTISRQKKKLRELSVELKKCKSKAKNVEEEEEQIRDLNNQIRAREKTFFEMESFLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILMVLSFICRFLLNSRVTDAVFNFLLVWYYCTLTIRESILINNGSRIKGWWVLNHYISTFLSGVMLTWPDGLMYQMFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHNMDLTVEGFQSWMWRGLTFLLPFLFFGQFWQLYNAITLFKLARHPECKEWQVIMCGLPFLVHFLGNFFTTLRVVHQKFQKQN
What is the function of this protein?
Ion channel involved in sensing mechanical pain.  Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli.  May also be required for efficient adipogenesis.
What are the official names of this protein?
Ion channel TACAN, Transmembrane protein 120A.
What is the protein family that this protein belongs to?
Belongs to the TMEM120 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein.
Protein: RLME_YERPE
Sequence: MSNKKRSASSSRWLQEHFSDKYVIQAQKKGLRSRAWFKLDEIQQSDKLFKQGMTVVDLGAAPGGWSQYAVTQIGSKGRVIACDLLPMDPIVGVDFLQGDFRDELVLKALLERVGDKKVQVVMCDMAPNMSGTPAVDIPKSMYLVELALDMCRDVLAPGGSFLVKVFQGDGFDEYLREIRSLFTKVKIRKPDASRARSREVYIVATGRKL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPTD_FRATO
Sequence: MLKGIHKYLLMCFGTVLFTVQANAARIMSNNPIKEDWQCKVVDGEWSCKRAKKPKSVFDKKLTKTEKEKALADDLAWVKKPSYFVGGYYSNDNQFTKALCESKKTDLSYEKSEFDNYGTLIASGNVQVLQCDQELYGNNAIINLNSNNSAIRSLVMAGDVIVKQPSTGIVIRTTELDADMNNGTYSTGEAYFRLAREMPKTRIYDKEHFSGYLRGYAKTFKKESSGDIVLSDGYITSGDPYDNAWKITGNNIDIDTNTHMAYVKNGYFEIQDIPVMYIPYFSHPIDDRRRSGFLYPGFLQNANSGIGISVPYYFNLAPNYDLMLQSVIWSQRGIIENGTFRYMTKYFQGQFEGSLVPYDFKEGKMRSSFTLSTTGQYENINTNFKYEYVSDQNYYNDFSAGNVNLVTKTLLDREFDLTYTNDYVDSGLTVLDYGVVNPLLTVDNTPYAKLPEVKLNLTSDGYTPDYLTLSAQTLNTFFYKTAGPANTNPGAPQGTNVNAFRAYESPKIAFNFNKTWGYLKPSLELPIRYYKLNNKPTDIIKFKNSNVTSVLPIFNIDAGAYFDKDYTNENGTYTSTLHPRLFYTYIPYQDQTNIPLFDTSLQNEQYMQMFQVNRFTGYDRINNANQLTYAIEASTTNQDNGTTLASAKIGQMAYFADRKVNLCQGNSACPNPGLMDPFSTDTFSPIMSSFEFQVMKNIYLSAQVNYRVKQQNVDYQVYQLSYKDENENIFNVSYNNIANNWNSLTQQQIAEGAKPQPQETITLSTVLNITDHWGIAALWNYNFQQKQIANIFAGLQYNAKSWAVRALWQKTAYTNQDPNNPTLLGPLVNTYMFEFELKGLGGIGNTSDISSRLQQINGYQVGEWGNGI
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: PNO1_GIBZE
Sequence: MPAPTALKQAESAPLANDISLPVEGADEEFLLDAPGAEDADANVLVPVEDSNDMQIDEEGRPRFAPARDIDPVTRVETRKIPIPPHRMTPLKQSWTSIYPPLVEHLKLQCRMNIKRKTVELRSSKHTTESGALQKGEDFVKAFTLGFDVDDAIALLRLDDLYIQSFEIKDVRTMHGDSQARAIGRIAGKDGKTKFAIENASRTRIVLADSKIHILGGFKNIHLARESVVSLILGKPPGKVYGNLRTVAARMKERF
What is the function of this protein?
Required for small ribosomal subunit (SSU) synthesis.  Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein PNO1.
What is the protein family that this protein belongs to?
Belongs to the PNO1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: Y0785_MYCTU
Sequence: MALTCTDMSDAVAGSDAEGLTADAIVVGAGLAGLVAACELADRGLRVLILDQENRANVGGQAFWSFGGLFLVNSPEQRRLGIRDSHELALQDWLGTAAFDRPEDYWPEQWAHAYVDFAAGEKRSWLRARGLKIFPLVGWAERGGYDAQGHGNSVPRFHITWGTGPALVDIFVRQLRDRPTVRFAHRHQVDKLIVEGNAVTGVRGTVLEPSDEPRGAPSSRKSVGKFEFRASAVIVASGGIGGNHELVRKNWPRRMGRIPKQLLSGVPAHVDGRMIGIAQKAGAAVINPDRMWHYTEGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFPGFDTLGTLEYITKSGHDYTWFVLNAKIIEKEFALSGQEQNPDLTGRRLGQLLRSRAHAGPPGPVQAFIDRGVDCVHANSLRELVAAMNELPDVVPLDYETVAAAVTARDREVVNKYSKDGQITAIRAARRYRGDRFGRVVAPHRLTDPKAGPLIAVKLHILTRKTLGGIETDLDARVLKADGTPLAGLYAAGEVAGFGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR
What is the function of this protein?
Able to catalyze the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids.
What are the official names of this protein?
KsdD-like steroid dehydrogenase Rv0785.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family.
Protein: FDHE_ECOSE
Sequence: MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNLYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLPRDKHWQKLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCGSMPVSSMVQIGTTQGLRYLHCNLCETEWHVVRVKCSNCEQSGKLHYWSLDDEQAAIKAESCDDCGTYLKILYQEKEPKVEAVADDLASLVLDARMEQEGYARSSINPFLFPGEGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_CUTAK
Sequence: MTLVSDDAIADRLYRDNYKTIRQYVDILVSRGVDWGLIGPREIGRLWERHILNSIALESLIPEGCRVADVGSGAGLPGIPLAILRPDLEMTLIEPMLRRSNFLTEALDELGLDDRVTVVRGRAEDADLHVDVVVSRAVAKLATLINWTADLIVESGSLLALKGQSADDEVVKAKKELSKRRLSAEVLLIRADPAADVTRAVRVRRAGK
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB10_PONAB
Sequence: MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEPNSENVDISSGGGVTGWKSKCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity).  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity).  That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity).  Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity).  In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity).  Also plays a specific role in asymmetric protein transport to the plasma membranes (By similarity).  In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane.  In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (By similarity).  May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity).  May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (By similarity).  Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (By similarity).  When phosphorylated by LRRK2 on Thr-73, it binds RILPL1 and inhibits ciliogenesis (By similarity).
What are the official names of this protein?
Ras-related protein Rab-10.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane. Cell projection, cilium. Endoplasmic reticulum membrane. Cytoplasm, perinuclear region. Note=Associates with SLC2A4/GLUT4 storage vesicles (By similarity). Localizes to the base of the cilium (By similarity). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulum at domains of new tubule growth (By similarity).
Protein: NEK3_ORYSJ
Sequence: MEQYEVLEQIGKGSFGSALLVRHKVEKKRYVLKKIRLARQTDRCRRSAHQEMELIAKVRNPYIVEYKDSWVEKGCYVCIVIGYCEGGDMSEAIKKANSNYFSEERLCMWLVQLLMALDYLHVNHILHRDVKCSNIFLTKDQNIRLGDFGLAKVLTSDDLTSSVVGTPSYMCPELLADIPYGSKSDIWSLGCCLYEMTALKPAFKAFDMQTLINKISKSVLAPLPTIYSGAFRGLIKSMLRKSPDHRPSAAELLKHPHLQPFVLELQLKSSPARNLFPDTNKASCSDDENNWKAKYSKSHSFKVDRIVKVDKVAANNGHPSSTGTAKDYQELLKQPMDELLGQLTEKVVDEVIHGNHSRVTKSPAPTPRRASSTPRIRLEPSKTFHARAAETPPSKCSLERASQPTRRASTPVNMLQTPEKRQGADILTRLKSPDVSVNSPRIDRIAEFPIPSFDDEQLHPTTKLKLYPPSITDQSITKDKCTFQVLRSDSSKNHTGDSSDPSILGTDSNPLITSSSDWMKQRRFDTTSYRQRAEALEGLLEFSAQLLQQERFEELGILLKPFGPGKASPRETAIWLSKSFKGTGL
What is the function of this protein?
May be involved in plant development processes (Probable).  May function downstream of DCW11 in retrograde signaling from the mitochondria to the nucleus.  Seems to be involved in the mechanism of cytoplasmic male sterility (CMS) occurrence (PubMed:19224952).
What are the official names of this protein?
Serine/threonine-protein kinase Nek3, NimA-related protein kinase 3, OsNek3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Protein: DEP1A_HUMAN
Sequence: MESQGVPPGPYRATKLWNEVTTSFRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRNNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGSENVDDNNQLFRFPATSPLKTLPRRYPELRKNNIENFSKDKDSIFKLRNLSRRTPKRHGLHLSQENGEKIKHEIINEDQENAIDNRELSQEDVEEVWRYVILIYLQTILGVPSLEEVINPKQVIPQYIMYNMANTSKRGVVILQNKSDDLPHWVLSAMKCLANWPRSNDMNNPTYVGFERDVFRTIADYFLDLPEPLLTFEYYELFVNILVVCGYITVSDRSSGIHKIQDDPQSSKFLHLNNLNSFKSTECLLLSLLHREKNKEESDSTERLQISNPGFQERCAKKMQLVNLRNRRVSANDIMGGSCHNLIGLSNMHDLSSNSKPRCCSLEGIVDVPGNSSKEASSVFHQSFPNIEGQNNKLFLESKPKQEFLLNLHSEENIQKPFSAGFKRTSTLTVQDQEELCNGKCKSKQLCRSQSLLLRSSTRRNSYINTPVAEIIMKPNVGQGSTSVQTAMESELGESSATINKRLCKSTIELSENSLLPASSMLTGTQSLLQPHLERVAIDALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPKLHDAMGTRSLMIHTFSRCVLCCAEEVDLDELLAGRLVSFLMDHHQEILQVPSYLQTAVEKHLDYLKKGHIENPGDGLFAPLPTYSYCKQISAQEFDEQKVSTSQAAIAELLENIIKNRSLPLKEKRKKLKQFQKEYPLIYQKRFPTTESEAALFGDKPTIKQPMLILRKPKFRSLR
What is the function of this protein?
May be involved in transcriptional regulation as a transcriptional corepressor.  The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.
What are the official names of this protein?
DEP domain-containing protein 1A.
Protein: HDHD2_RAT
Sequence: MAARRVLKAVLVDLSGTLHIEDAAVPGAQEALKRLRAASVMVRFVTNTTKESKRDLLERLRKLEFDISEEEIFTSLTAARNLIEQRQVRPMLLVDDRALPDFTGVQTHDPNAVVIGLAPEHFHYQLLNEAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKAVVVGKPEKTFFLEALRDTDCAPEEAVMIGDDCRDDVDGAQNIGMLGILVKTGKYKAADEEKINPPPYLTCESFPHAVDHILQHLL
What are the official names of this protein?
Haloacid dehalogenase-like hydrolase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
Protein: 3HIDH_PONAB
Sequence: MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGATLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF
What are the official names of this protein?
3-hydroxyisobutyrate dehydrogenase, mitochondrial, HIBADH.
What is the protein family that this protein belongs to?
Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: OXR1_SCHPO
Sequence: MFNFTRQYSVKDGLITDELASHIVENLPARYASAETWKRIYSLQHDGASLQTMYLACEKEKARSGHPKGACILAVRDTDGDVFGVFIPDYLIPAPHYFGSEETFLWKYFPPKKYVHYPFVGNSNFVAYCTKSFLAFGGGNGRYSLWLDGSLEYAYSSRTPAFENNPLSYRGCPDQRIQIVDIELWVLE
What is the function of this protein?
May be involved in protection from oxidative damage (By similarity).  Has a role in meiosis.
What are the official names of this protein?
Oxidation resistance protein 1, Meiotically up-regulated gene 63 protein.
What is the protein family that this protein belongs to?
Belongs to the OXR1 family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm. Nucleus.
Protein: Y3777_PECAS
Sequence: MDYEFLRDVTGQVIVRMSMGHEAIGHWFNEEVKGQLTVLTDVEDGARSVAGSERQWRRVGHEYTLLLDEEEVMVQANQLSFTTDELEEGMSYYDEESLSLCGLDDFLTLVEKYREFILH
What are the official names of this protein?
UPF0231 protein ECA3777.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: PURA_CORU7
Sequence: MAAIIVVGAQWGDEGKGKATDILGGQVDYVVKPNGGNNAGHTVVVGGEKYELKLLPAGILSDNATSIIGNGCVVNLEALFEEIDGLQARGADTSHLRVSANAQLVAPYHVAIDRVSERFLGKRAIGTTGRGIGPTYQDKVGRVGIRAQDLLDESILRQKIESALDKKNQMLVKMYNRRAIEPEEVVQYFLSYADRLAPMLIDSSKVLNEALDRGERVLMEGGQATMLDVDHGTYPFVTSSNPTTGGACVGSGVGPTRITSSLGIIKAYTTRVGAGPFPTELFDKWGEYLQTTGGEVGVNTGRPRRCGWYDSVIARYASRVNGFTDYFLTKLDVLTGIGEIPICVAYDVDGVRHDEMPMTQTEFHHATPIYETMPAWDEDITGCRTFEELPEKAQDYVKRLEELSGCRMSYIGVGPGRDQTIVINDILKD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_CERS4
Sequence: MSDTDGKKPLGLGGGSRSGQVKQSFSHGRTKSVLVETKRKRVVVPKPGASGSSTTTSSPSHLGDPAKRPAGISDAEMERRLAALRAAKLREVEDAKRRADEERQREEERQRRREELEAKEREERERAEALRQKAEDEERARREAEEAARRAEEAKRAPAPAAPQPAPAESRASAPPSAKPGLPPSRKEREREADRDRTTKKDDSRRSGKLTLNEALSGEGGRTRSLAAMKRKQEKARQKAMGFGHKAEKQVRDVQLPETILVQELANRMAERAADVVKALMKMGMMVTMNQSIDADTAELVIEEFGHRAVRVSDADVEHVIDTVEDKAEDLQPRPPIITIMGHVDHGKTSLLDAIRKTSVVSGEAGGITQHIGAYQVKTESGAVLTFLDTPGHAAFTSMRARGAQVTDIVVLVVAADDAVMPQTVEAIKHAKAAKVPMIVAINKIDKPDADPNKVRTDLLQHEVIVEKMSGDVLDVEVSAKTGLGLDELLENIALQAEILDLRANPSRQAQGAVIEAKLDVGRGPVATVLVQYGTLKRGDIFVVGQQWGKVRALINDKGERVDEAGPSVPVEVLGLNGTPEAGDVLNVVETEAQAREIADYREKAARDKRAAAGAATTLEQLMAKAKADADVAELPVVIKADVQGSAEAIVQALEKVGNDEVRVRVLHYGVGAITETDITLAEASQAAVIGFNVRANASARQAANQKSVEIRYYSVIYDLVDDVKKAASGLLKAEVREHFIGYAQIKEVFRITGVGNVAGCIVTEGVARRSAGVRLLRDNIVIHEGTLKTLKRFKDEVKEVQSGQECGMAFERYEDIRPGDVIEIFEREEVQRKLA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCUB_SCHPO
Sequence: MEAAPSEKVPAKKLSSSENLDIGVSEVVTVDAAENNSNGIKRGLKTRHVSMMALAGIIGPGVFIGMGSALHIGGPVGLIVGFAIVSIVVFGVMLSIGEFNSLFDFNFNTHAARWVDPAFGAAIGWNYVIVWLTNIAAEYTSLTSILQYWGPHVPSYGFFLIFWGFFTCYQMLGVSVFGESEYILAFIKLLFITGFYIFAIIYAAGGIPHHKPPNLFKEMPLAHGFGGIVSAFVYAGVFFSGVESVSMTAAESKNPKKAIPLAVRQTFWRILYVYFGISISYGITVAWNDPNLSSGSKTLKSPMTIAIMNAGWNHAGDFVNAVILITCLSSINSGIYIGSRSLYNLAKDGMAPKIFKRVDKRGVPWVAVHSVHLFGFLSIMNYSTGAVKAYGYIINLAGVSAFIVWTAIIFVHFRFRRGWVKQGYALSDLPFKSPLYPFPQLIGFVIGIILTLVQGWTVFKPFAAGDFVDAYILLPLFFVIWLSYKFIKKTKWVSYEDMDFINGRRVIEPTYSNEQSSDKETEDGKKTSFWNRVWKEV
What are the official names of this protein?
Uncharacterized amino-acid permease C965.11c.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YBEY_STAAW
Sequence: MFTIDFSDHTGLVKDAWYKQIEDLLEFAKKEEHIEDDAELSVTFVDKQEIQEINRTYRDKDKVTDVISFALEEDEPEIDFSGLDIPRVLGDIIICTDVAQEQANNYGHSFERELGFLALHGFLHLLGYDHMTEADEKEMFGRQDTILNAYGLTRG
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CX6B1_MOUSE
Sequence: MAEDIKTKIKNYKTAPFDSRFPNQNQTKNCWQNYLDFHRCEKAMTAKGGDVSVCEWYRRVYKSLCPVSWVSAWDDRIAEGTFPGKI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1, COX VIb-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 6B family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: TSC10_ASHGO
Sequence: MKYELNGQVVLISGGSQGLGRAFAQKYIEESDSTVVIVSRSEEKLTRAGEAICGGARRLGAGGAGRLLYYACNLGDAAAVGGLFATLADAGLQVTQVLFCAGGAVPGLFAELSSAQLAAGVEMNYGTALHLAHGAVRHGARHLVFFSSAAAVYPFIGYSQYAPLKAALRALVAVLRQECDGVRVSCVYPGNFASEGYAEENRTKPAITAAIEGSSEAISCAACCDKIVRGLRSGYDDVTTDFVGWLLLACNMGFNYHSTTYFLWPLGWLLGALVNLLVVPIYMLLCRWDIHKWRTQREETHLAAKTD
What is the function of this protein?
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
What are the official names of this protein?
3-ketodihydrosphingosine reductase TSC10, 3-dehydrosphinganine reductase, KDS reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: VATC_HORVU
Sequence: MATRYWIAALPVADDNVAAGKTALWARLQEAISRHSFDTPLYRFTVPDLRPGTLDSLLALSDDLVKSNIFIEGVSHKIRRQIEDLERAGGVEPGTLTVDGVPVDSYLTRFVWDEGKYPVNAPLKETVASIQSQVAKIEDDMKVRVAEYGNVKSQLGAINRKQTGSLAVRDLSNLIKPEDMVTSEHLVTLLSIVPKYSQKDWLASYESLDTFVVPRSSKKLYEDNEYALYTVTLFAKVVDNFKVHAREKGFQIRDFEYSPEAQESRKQELEKLLQDQEVMRTSPIAMGAMLATVRVFSSWDAFSSAVRVFVESILRYGSACTVPVCCPSTIYKEREKSKEHLGRAMRQYQQLLEI
What is the function of this protein?
Subunit of the peripheral V1 complex of vacuolar ATPase.  Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit C, V-ATPase subunit C, Vacuolar proton pump subunit C.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase C subunit family.
What are the subcellular locations of this protein?
Vacuole membrane. Note=Tonoplast.
Protein: EIF3H_DROWI
Sequence: MANRGGRHARTEETENAINYVQCDGLAVMKMVKHCHEESNNMDLAQGALLGLVVDKCLEITNCFPFPKSGDETMDEEMYQLTVMRRLRRVNVDHLHVGWYQSSDVGNSLSLALLESQYHYQTSIEESVVVVYDTQKSSRGFLCLKAYRLTPQAIQMYKDGDFTPEAFRNLKVGYESLFAEIPIVIKNSPLTNIMMSELNELLPEDKGHNFLDLGTASVLENHMRSLIERVDELYQEAVRYNKYQQVVFKQDTEKHRALAKLAAENAVRTSKGEPTVSEEEVIKQFRPMPVPARLTATITSGQINTHAQHIAQFCSQSLAKLFITESLQNAKEAKEIK
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit H, eIF3h, Eukaryotic translation initiation factor 3 subunit 3.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit H family.
What are the subcellular locations of this protein?
Cytoplasm.