PharMolix/UniProtQA huggingface dataset:
Protein: ROR1_HUMAN
Sequence: MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL
What is the function of this protein?
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443).  Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).  In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).
What are the official names of this protein?
Inactive tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase, receptor-related 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Protein: PIP23_ORYSJ
Sequence: MAKDIEAAAAAEGGEYMAKDYSDPPPAPLIDAEELTKWSLYRAVIAEFVATLLFLYITVATVIGYKHQSDPGANAADAACSGVGILGIAWAFGGMIFILVYCTAGVSGGHINPAVTFGLFLARKVSLVRAVLYIVAQSLGAICGVGLVKGFQSAFYVRYGGGANELSDGYSKGTGLAAEIIGTFVLVYTVFSATDPKRNARDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGAAVIYNQHKAWHDHWIFWVGPLIGAAIAAAYHQYVLRASAAKLGSSSSFRG
What is the function of this protein?
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
What are the official names of this protein?
Probable aquaporin PIP2-3, OsPIP2;3, Plasma membrane intrinsic protein 2-3.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROC_BRUO2
Sequence: MSHNSFGHLFRVTTWGESHGLALGCVVDGCPPGITFTEAEIQSFLDKRKPGQSKYTTQRREPDQVRVLSGVLLGEDGVTMTTTGTPISMMIENTDQRSKDYGEIARQYRPGHADYAYDVKYGIRDYRGGGRSSARETAARVAAGAIARKVVPGLEVRGALVSIGAHDIDRSRWNWAEVDNNPFFTPDAGSVEVFADYLDGIRKNGSSVGAIIEIVAEGVPAGIGAPIYGKLDQDIASYLMSINAVKGVEIGNGFEAARLTGEENADEMRMGNDGKPIFLSNHAGGVLGGIATGAPVVARFAVKPTSSILTPRRSIDKDGNEVDVMTRGRHDPCVGIRAVPIGEAMVACAIADHYLRHRGQTGRV
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PYRB_CALMQ
Sequence: MTWLNRDVISSLDFTRDDLMQLFYEAKEMENYAKSKLNILDGKIMATAFFEPSTRTRLSFETAMLRLGGRVLGFGSVEASSVAKGESLGDTIRMLDSYSDIIVIRHSLEGAAKYAADIATVPVINAGDGTQNHPTQAMLDAYTIWREYGRLDDLTIGILGDLRYARVVTSLVQLLSNFKVKLRLISPEILRPRRELVDFMRMRGMNYSLHSNLNEVLSELDVLYVVRIQRERFPDPVEYERVKGSFKVTPESLIGAKDTLIILHPLPRVDEVDHRLDSTRYARYFRQSALGVPLRMALLKLVLKGD
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: ABCG4_HUMAN
Sequence: MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER
What is the function of this protein?
ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061).  May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol.  However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity).  Induces apoptosis in various cells (PubMed:27228027).
What are the official names of this protein?
ATP-binding cassette sub-family G member 4.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endosome membrane; Multi- pass membrane protein.
Protein: PYRB_PROM1
Sequence: MNNWKHNHVLDLSTFSLEDYKTVLELTTRFKDVHKSSSKKLPALHGRLIANLFFEPSTRTRTSFELAAKRLSADVQNFSVSSSSLSKGETPLDTILTYISMGADILVIRHESTNVPAELANYVDINNINTSILNAGDGFHSHPSQGLLDLFTLATFFNPNEPSTNSLLNKKITIVGDILHSRVARSNLWALTACGAEVTLCGPPSLLPEEFIDFVQNPRLGQNFDPINKRGSVFIKRSLKDALKNSDAVMTLRLQKERMKQNMLKDLDSYYAQYGITHESLKWCEKKVPVLHPGPVNRGVEISNRLVEDNSINLISKQVENGIPTRMALLYLLGLNKKD
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: COX19_SCHPO
Sequence: MSFGAAGGSLPMTTREPPERGSFPLDHFGECTHVMKQYLECIKVKRENQEECRLLAKKYLQCRMDTGLFGKDDMKNLGFHGDENATSTSLSSSNDGNNNSNSSSSDNKTGGE
What is the function of this protein?
Required for the assembly of mitochondrial cytochrome c oxidase.
What are the official names of this protein?
Cytochrome c oxidase assembly protein cox19, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX19 family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: GCST_PROM1
Sequence: MKLLQTPLYQECKELGGKMVPFANWEMPVSFSGLIEEHNAVRKNVGMFDISHMGVVQLKGKNIKSALQNLVPSDVFRIGPSEACYTVFLKENGGIQDDLIIYDQGVLDTNEESVVLVINAARKESDVEWLSSNLSKKEITISEFMPEGALIAIQGPESISTLEKILEEPLSNLPRFGHRTITSNPNLINSQESIFIARTGYTGEEGFEFLSSPETAKSIWKSLIASGVTPCGLGARDTLRLEASMHLYGNDINLDTTPFEAGLGWLVHLEMPNDFIGRKALEKQAEVGTQKKLVGIQVLDKGIARKGYPVLYNSETVGIVTSGTWSPTLQKPIALAYVPSEIAKVNTQIEVEIRGKKHPAIIVKRPFYRKGF
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: DNAK_CLOBK
Sequence: MAKIIGIDLGTTNSCVSVMEGGEPVVIPNAEGSRTTPSVVSFQANGERLIGQVAKRQAITNPEKTIISIKRYMGTDHKVNIDSTEYTPQQISAMVLQKLKADAEAYLGEKVTQAVITVPAYFNDSQRQATKDAGKIAGLEVLRIINEPTAASLAYGLDKMDTNEKILVYDLGGGTFDVSILELGDGVFEVKATNGDTKLGGDDFDQKLIDYIAETFKAENGIDLRNDKMAIQRLKEAAEKAKIELSSATQTNINLPFITADATGPKHIDMNLTRAKFNELTHDLVQRTLEPIKKSLEGSGYAMSDIDKIIMVGGSTRIPAVQDAVKDFTGKELSKGVNPDEVVAMGAAIQAGVLTGEVKDVLLLDVTPLTLGIETFGGVSTTLIEKNTTIPTRKSQVFSTAADGQTSVEIHVVQGERSMAADNKTLGRFTLSGIAPAPRGIPQIEVTFDIDANGIVNVSAKDKGTGKEANITITASTNLTDDEIEKAVNEAKKFEAEDKKRKESIEVKNNADQIVYQTEKTLTDLGDKVSAEDKAQIEEKVKAVKDVKEGEDLEAIKKATEDLTQTFYGISSKIYQQANPEGAQGAGFDPNNMGGANAGNASAENDKKDDNVVDADYKVEDDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PPB_SCHPO
Sequence: MASERDPLLPVHGEGPESPSRRNWKTWIKHGILLILVLSTVIFFYFFSSHKSKGTNEKPKFVIMMVSDGMGPGSLSMTRSFVETLNDKEGYRLPLDEHLIGSSRTRSSSSLITDSAAGATAFSCANKTYNGAVGVLDNEKPCGTILEAAKEAGYLTGIVVTSRVTDATPASFSAHAANRFMQDLIAEYQVGMGPLGRSVDLLFGGGLCSFLPKSTYRSCRSDNLDLLKYARKKEGFQILLNRTDFDELSNAQLPLLGLFSDYHLSYDIDYQPEVQPKLSEMVETALDVLLNATNEDTSKGFFLLIEGSRIDMASHNNDPIAHVYEVMEYNRAFEIASAFVEKNGGSLISTSDHETGGLTVGRQVSKKYPEYLWKPQVLSLALHSIEYLASAIVNHNQNTLLPYIEQFVLPAIGIPDPNPKQIHDIYVARHNIFNLINVLSDIVSVEAQIGWTTHGHTAVDVNVYGVGEVTEHLRGNMENIEIGQFMEIYLNVSLSDVTEKLKDAPIHGAPDRPSLVETSFSDRLVGFGADLF
What are the official names of this protein?
Alkaline phosphatase.
What is the protein family that this protein belongs to?
Belongs to the alkaline phosphatase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RNF32_MOUSE
Sequence: MLRNKDRSSNKGNLAVTAVALQDHLLHDLQLGHLSVADPCKIKARKKEKKSKSLKRDATAIIDTGLRKSTEGPNMEDPEKEYVLDPTPPPLTLAQKLGLLPPPPLPLSSDEWERVKQRSLLQGDSIQPCPICKEEFELHPQVLLSCSHVFHRACLQAFEKFTNKKTCPLCRKNQYQTRVIHDGARLFRVKCATRIQAYWRGYIVRKWYRNLRKIIPPSDAKLRRKFFEEKFTEISHRILCSYNTNIDELFSEIDVCLAVNRSILQQLDERCGQIITKEDWEKIQAQAAHHEIYECSICLTPLSFHGDGRQAAIGTSSQRPRETVLLSCAHLFHNACLLALEEFSLGDNAPFHVCPLCRSCYQKKIVEC
What is the function of this protein?
May play a role in sperm formation.
What are the official names of this protein?
RING finger protein 32, Limb region protein 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_MYCPA
Sequence: MNASQRVRVAVVFGGRSNEHAISCVSAGSILRNLDPRRFEVVAIGITPQGSWVLTDGDPAALAISDRQLPEVTSASGTELALPADPGRSGQLVSLPPGASEVLASVDVVFPVLHGPYGEDGTIQGLLELAGVPYVGAGVFASAAGMDKEFTKKLFAAEGLPIGDYAVLRPSQSTLSLQDRERLGLPVFVKPARGGSSIGVSRVSSWDELDAAVAAARDHDPKVIVEAAIAGRELECGVLEMPDGTVQASTVGEIRVAGVRGREDSFYDFATKYLDDTAELDVPAKVDDEIADAVRELAIRAFKAVDCQGLARVDFFLTETGPVLNEINTMPGFTTISMYPRMWAASGVDYPSLLATMVETALARGVGLR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_RHOP2
Sequence: MPKLKTKSGAKKRFKVTATGKVMSAQRGKRHGMIKRTKKQIRQLRGTRVIFKTDGDNIKKYFLPNA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: AIM4_VANPO
Sequence: MNYINMKKIDEENKANSGDDTTESRKKQKTKNNEEHEIRSDELFRKSIFFDSHWNPNGVAPPNHRNVFYNPKTFVHRGKPIIAKLMDLDEEHLTKLISKTQK
What are the official names of this protein?
Altered inheritance of mitochondria protein 4.
What is the protein family that this protein belongs to?
Belongs to the AIM4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPAP2_DROME
Sequence: MTTEKGEQLRQQLIAAVVKKRAAIARAHEIVVRLLEPGIPEPEFLSLLCEIGPPNYSDIVDEREINKLCGYPLCSTVLENVPKQKYSISASKNKVYDITERKKFCSGYCFKASEYIKSQVPTSPLWLRDRETRPSFQLLPRNT
What is the function of this protein?
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
What are the official names of this protein?
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog, RNA polymerase II-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the RPAP2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS2_LEIXX
Sequence: MAVVTMRQLLDSGVHFGHQTRRWNPKMKRFILTERSGSYIIDLQQSLTYIDKTYDFVRETVAHGGTILFVGTKKQAQQAIAEQATRVGQPYVNQRWLGGLLTNFQTVSKRLARMKELEELDFEGTTSGFTKKELLIKKRELDKLHKSLGGIRNLSKTPSALWVVDTKKEHLAIDEAKKLGIPVIAILDTNCDPDEVQYPIPGNDDAIRSVSLLTHIVADAAAEGLIQRHQKPEEGVEAAEPLAEWEQELLAQPAAEVQASAETEKAADADLAEAKADSAAVVAEGEAAADAVAETPAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: USB1_SCHPO
Sequence: MSLVCYESSSSGEDDDETISDNPRMLKVPKLQESFHELYKKKPKTFDSPEFHEGRIRGQKHIEGLWFVQTYLEVDLSKKVKKGIREFLNSQSRFQSLLCSEHNVPRRLHLSISENYRINYSTKNQLVHKWEQYTNNLNYRTLKFRLGKMCLLFNDEKTRMFLAFECKFSDENYKDLISHASDCMKEFTNRNLREDFLLHISFASSLTNEDEYQNWVSQDRESHFFKTMNEIINTKIQKDQFSESFIVDSLKLSIGHLIFTFPFCK
What is the function of this protein?
3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. d (PubMed:26213367).  Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:26213367, PubMed:23022480).
What are the official names of this protein?
U6 snRNA phosphodiesterase 1, 3'-5' RNA exonuclease USB1, Mutated in Poikiloderma with Neutropenia protein 1.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. USB1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CD28_CHICK
Sequence: MLGILVVLCLIPAADVTENKILVAQRPLLIVANRTATLVCNYTYNGTGKEFRASLHKGTDSAVEVCFISWNMTKINSNSNKEFNCRGIHDKDKVIFNLWNMSASQTDIYFCKIEAMYPPPYVYNEKSNGTVIHVRETPIQTQEPESATSYWVMVAVTGLLGFYSMLITAVFIIYRQKSKRNRYRQSDYMNMTPRHPPHQKNKGYPSYAPTRDYTAYRSWQP
What is the function of this protein?
Possibly involved in T-cell activation.
What are the official names of this protein?
T-cell-specific surface glycoprotein CD28 homolog, CHT28.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PYRC_STRP3
Sequence: MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVLKEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVVAFAQQLGAKVTAEVSPQHFSTTEDLLLTAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKAVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPFIGNKLKGVVKYTIADGEVVYPN
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: RENBP_MOUSE
Sequence: MEKERETLQVWKKRVEQELDRVIAFWMEHSHDQEHGGFFTCLGRDGKVYDHLKYVWLQGRQVWMYCRLYRSFERFRRVELLDAARAGGEFLLRYARVAPPGKKCAFVLTRDGRPVKVQRTIFSECFYTMAMNELWKVTGEVRYQSEAIEMMDQIIHWVREDPAGLGRPQLSGALATEPMAVPMMLLSLVEQLGEEDEELTNMYAELGDWCVHRILQHVQRDGQVVLENVSEDGKELPGCLGRHQNPGHTLEAGWFLLQYALRKGDPKLRMHIIDKFLLLPFHSGWDPEHGGLFYFQDADGLCPTQLEWNMKLWWPHSEAMIAFLMGYSDSGDPALLHLFYKVAEYTFRQFRDPEYGEWFGYLNQEGKVALTIKGGPFKGCFHVPRCLAMCEQILGALLQRLEPAPLDSSPAVSTHEGSK
What is the function of this protein?
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:22692205).  Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (PubMed:22692205).
What are the official names of this protein?
N-acylglucosamine 2-epimerase, AGE, GlcNAc 2-epimerase, N-acetyl-D-glucosamine 2-epimerase, Renin-binding protein, RnBP.
What is the protein family that this protein belongs to?
Belongs to the N-acylglucosamine 2-epimerase family.
Protein: SOTB_SALPA
Sequence: MTINPVSRKVAWLRVVTLAIAAFIFNTTEFVPVGLLSDIAESFHMQTAQVGIMLTIYAWVVAVMSLPFMLLTSQMERRKLLICLFVLFIASHVLSFLAWNFTVLVISRIGIAFAHAIFWSITASLAIRLAPAGKRAQALSLIATGTALAMVLGLPIGRVVGQYFGWRTTFFAIGMGALITLLCLIKLLPKLPSEHSGSLKSLPLLFRCPALMSLYVLTVVVVTAHYTAYSYIEPFVQNVAGLSANFATVLLLLLGGAGIIGSLVFGKLGNRHASSLVSIAIALLVVCLLLLLPAADSEAHLAILSIFWGIAIMVIGLGMQVKVLALAPDATDVAMALFSGIFNIGIGAGALVGNQVSLHWSMSAIGYIGAIPACAALVWAVLIFRKWPVTLEEQPH
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
What are the official names of this protein?
Probable sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FADB_PSEA7
Sequence: MIYQGKAITVKPLEGGIVELNFDLKGESVNKFNRLTLSELRAAVDAIKADAAVKGVIVTSGKDVFIVGADITEFVDNFQLPDEELMAGNLEANKIFSDFEDLDVPTVAAINGIALGGGLEMCLAADFRVMSATAKVGLPEVKLGIYPGFGGTVRLPRLIGCDNAVEWIASGKENKAEDALKVGAVDAVVAPEQLQAAALDLAKRAVAGELDHKARRQPKLEKLKLNAIEQMMAFETAKGFVAGQAGPNYPAPVEAIKSIQKAANFGRDKALEVEAAGFVKLAKTSVAQSLIGLFLNDQELKKKAKKYDEVAKDVKLAAVLGAGIMGGGIAYQSALKGTPILMKDIREEGIQMGLNEAAKLLGKRVEKGRLTPAKMAEALNGIRPTMSYGDFGNVDIVVEAVVENPKVKQAVLAEVEGAVKEDAIIASNTSTISISLLAQALKRPENFCGMHFFNPVHMMPLVEVIRGEKTGETAIATTVAYAKKMGKSPIVVNDCPGFLVNRVLFPYFGGFAKLLGFGVDFVRIDKVMEKFGWPMGPAYLSDVVGIDTGHHGRDVMAEGFPDRMAVEGKTAVDVMYEANRLGQKNGKGFYAYETDKRGKPKKVTDPQAYEVLKPIVVEQREVTDEDIVNFMMIPLCLETVRCLEDGIVETAAEADMGLIYGIGFPPFRGGALRYIDSIGVAEFVALADKYAELGALYHPTAKLREMAKNGQKFFG
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: KLF13_HUMAN
Sequence: MAAAAYVDHFAAECLVSMSSRAVVHGPREGPESRPEGAAVAATPTLPRVEERRDGKDSASLFVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPPAPEPTSPGAEGAAAAPPSPAWSEPEPEAGLEPEREPGPAGSGEPGLRQRVRRGRSRADLESPQRKHKCHYAGCEKVYGKSSHLKAHLRTHTGERPFACSWQDCNKKFARSDELARHYRTHTGEKKFSCPICEKRFMRSDHLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRSDASSPTISPASSP
What is the function of this protein?
Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1.  It also represses transcription by interacting with the corepressor Sin3A and HDAC1.  Activates RANTES expression in T-cells.
What are the official names of this protein?
Krueppel-like factor 13, Basic transcription element-binding protein 3, BTE-binding protein 3, Novel Sp1-like zinc finger transcription factor 1, RANTES factor of late activated T-lymphocytes 1, RFLAT-1, Transcription factor BTEB3, Transcription factor NSLP1.
What is the protein family that this protein belongs to?
Belongs to the Sp1 C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MYT1L_MOUSE
Sequence: MDVDSEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECYESDGTEDMDDKEEDDDEEFSEDNDEQGDDDDEDEVDREDEEEIEEEDDEEDDDDEDGDDVEEEEEDDDEEEEEEEEEEENEDHQMSCTRIMQDTDKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENISDRSYAEGMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQDRSQPPNMSVRQHVRQEDDFPGRTPDRSYSDMMNLMRLEEQLSPRSRTFSSCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMDAGRRDNLRSYEDQSPRQLAGEDRKSKSSDSHVKKPYYGKDPSRTEKRESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHENVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSNQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKNASPSSSTTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCTARNPDMEVDENGTLDLSMNKQRPRDSCCPVLTPLEPMSPQQQAVMSSRCFQLSEGDCWDLPVDYTKMKPRRVDEDEPKEITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV
What is the function of this protein?
Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation (PubMed:28379941).  In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (PubMed:28379941).  Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (PubMed:28379941).  The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220).  Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (PubMed:28379941).  The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (PubMed:28379941).
What are the official names of this protein?
Myelin transcription factor 1-like protein, MyT1-L, MyT1L, Neural zinc finger factor 1, NZF-1, Postmitotic neural gene 1 protein, Zinc finger protein Png-1.
What is the protein family that this protein belongs to?
Belongs to the MYT1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Preferentially binds to DNA binding sites that are in an open chromatin configuration (PubMed:28379941).
Protein: MBR1_YEAST
Sequence: MRMEKTTDKPLSAGDMNDEYSRGPIDDIDCLNFFERAVQDPCCEACDTEDADEELRAKLSSFNFQPDSSPCNAKCQQTLNPLCKIDEALPAESELAPSRNGSVSEANSDTNSIASTVHDPVDSKYGGMPSLRKAKTTSYFTSSSSNNTTMRNPLKKCNTNINGLLVNGRSSSSSRQSIPELFSGACTKKKNNVLLKSETPNSEFSSNSLQHCNSRSFSLPRSRSRSSAIAIPTHLYGLEKYVSPGLDTLTADPEESIERFSNNRPREISSCCPNDTGDTSSSLSHSNTSSSLNFPLGTNTNQFHQPRQPVQQQQSSKPNFGAGRKKSFIEMSLASSFAG
What is the function of this protein?
Participates in mitochondrial biogenesis and stress response.
What are the official names of this protein?
Mitochondrial biogenesis regulation protein 1.
What is the protein family that this protein belongs to?
Belongs to the ISF1/MBR1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: H1_EUPEU
Sequence: MPAKTATAVKRTTTTKKSAAKRKTSKAVKKAGKRTQSKAKGAQKVKKAATRRTPSKSAGARKATKKAGARKASTKRSATKKTTAAPAAAAAPATDAPAAAATPSKATGSAKKASARKSSAKKPAKGGKKKSAKKN
What is the function of this protein?
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
What are the official names of this protein?
Histone H1, macronuclear.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Macronuclei.
Protein: GLGB_FELCA
Sequence: MAAPVARGECSEAALAAALADVPELARLLELDPYLKPFALDFQRRYKKFNETLNNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEGVFLTGDFNDWNPFSYPYKKLDYGKWELYIPPKQNKSQLVPHGSKLKVVIRSKSGEILYRISPWAKYVTREGENVNYDWTHWDPEHPYKFKHSRPKKPRGVRIYESHVGISSYEGKIASYKHFTYNVLPRIKDLGYNCIQMMAIMEHAYYASFGYQITSFFAASSRYGTPEELKELVDTAHSMGITVLLDVVHSHASKNSEDGLNMFDGTDSCYFHSGPRGNHDLWDSRLFIYSSWEVLRFLLSNIRWWLEEYGFDGFRFDGVTSMLYHHHGMGQAFSGDYHEYFGLQVDEDALIYLMLANHLVHTLYPNSITIAEDVSGMPALCSPISQGGVGFDYRLAMAIPDKWIQLLKEFKDEDWNMGNIVYTLTNRRYLEKCIAYAESHDQALVGDKTLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHALGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNKLEERCGWLSAPQAFVSEKHEGNKIIAFERAGLVFIFNFHPSKSYTDYRVGTTLPGKFRIVLDTDAAEYGGHQRLDHSTEFFSQPFKHNERPCSLLVYIPNRVGLILQNVDMPN
What is the function of this protein?
Required for normal glycogen accumulation.  The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule.
What are the official names of this protein?
1,4-alpha-glucan-branching enzyme, Brancher enzyme, Glycogen-branching enzyme.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.