PharMolix/UniProtQA huggingface dataset:
Protein: VP6_ROTBS
Sequence: MDVLFSIAKTVSELKKRVVVGTIYTNVEDIIQQTNELIRTLNGSTFHTGGIGTQPQKDWVVQLPQLGTTLLNLDDNYVQSARGIIDYLASFIEAVCDDEMVREASRNGMQPQSPTLIALASSKFKTINFNNSSQSIKNWSAQSRRENPVYEYKNPMVFEYRNSYILHRADQQFGNAMGLRYYTTSNTCQIAAFDSTMAENAPNNTQRFIYHGRLKRPISNVLMKVERGAPNVNNPTILPDPTNQTTWLFNPVQVMNGTFTIEFYNNGQLVDMVRNMGIATVRTFDSYRITIDMIRPAAMTQYVQQLFPVGGPYSHQAAYMLTLSVLDATTESVLCDSHSVDYSIVANTRRDSAMPAGTVFQPGFPWEQTLSNYTVAQEDNLERLLLVASVKRMVM
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: YCF4_BIGNA
Sequence: MENVFIYRYTVLGSKKISNLIFAIFIFLGSIFFLKASIFSFLDLKTNSLNGNIVFFPQGLVMGFYSLLGLLFTFYSLLTFFLKIGFGYNEFNKKENVIRIFRWGFPGKNRRIEACYSINDIKSIKISSNTGPKNISISLKGDIDIPFIREGFSDSFSNIEEQAIDIASFLGIPLVYNQ
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: VOSA_BEAB2
Sequence: MARHKTSDIMLPAAWRIPWDRQLDQHMARVIKAMAQINFASNMHHNLFMFTTREGLLHRNRMLSSSTTQELQSTQPIAVRQQPRAARACGFGDRDRRVIDPPPIVQLRIDGPGLSEEERRAYLRYPNYVMNCSIWDESGTRDASYMPDEYNHQRRLMGSLVGTPFVGDDDQNQEGCFFCFSDLSCRTPGAFRLKFTLIMIDPARASILRHFPTLTEIKTDIFQVYSAKEFPGMVASSSLAKKLKEQGCIISIKKGNERARPRGADGRSDDEDD
What is the function of this protein?
Component of the velB-vosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (PubMed:26243054).  The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity).  Positively regulates the expression of wetA and represses abaA and brlA (PubMed:26243054).  Acts as a crucial regulator of both conidiation capacity and conidial quality (PubMed:26243054).  Responsible for the synthesis and accumulation of intracellular trehalose (PubMed:26243054).
What are the official names of this protein?
Spore development regulator vosA.
What is the protein family that this protein belongs to?
Belongs to the velvet family. VosA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SMG_YERPN
Sequence: MFDVLIYLFETYMHNEPEMLVDQDKITDDLADAGFYREDINNALNWLEVLADLQEGQKAPYLYTADPQALRIYTVEECRRLGAACRGFILFLEQIQVLQFDTREMVIDRIMALDSPEIDLEDLKWVVLMVLFNIPGYENAYKQMEELLFEVNDGYLH
What are the official names of this protein?
Protein Smg.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: SYP_ALISL
Sequence: MRTSKYLLSTLKETPNDAEVVSHQLMLRAGMIRRLASGLYTWLPTGLRVLRKVENIVRQEIDNAGAIETLMPVVQPFELWEETGRSEEMGPELLRFTDRHARPFVLSPTAEEVITSLVRNEVNSYKQLPLNLYQIQTKFRDERRPRFGVMRAREFCMMDAYSFDIDKEGLQKSYDAMHDAYCRAFDRMGLEYRPVLADSGAIGGSGSQEFHVLAESGEDLIAFSTESDYAANIEKAEALAPTTERAAPTQEMTTVDTPNAKTIAELVEQHGIAIEKTVKTLFVKASDEVDADIIALIIRGDHELNEVKAENLPHVLSPLEMADEAQLRDLIGAGAGSLGPVGLELPFIVDRSVAVMSDFSTGANIDGKHFFGVNWDRDVQLGQIEDLRSVVEGDLSPCGQGTLQLKRGIEVGHIFQLGTAYSEAMNCGVLDANGKNSILEMGCYGIGVSRVVASAIEQNNDEYGIVWPEALAPFTVAIVPMNMYKSDRVKEAAEKLYAELTAMGIDVLFDDRKERPGVMFKDIELIGIPHTVVIGDRSMDEGNFEYKNRRANSKEVIEIANIVEHIKAQLS
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_DEBHA
Sequence: MKQMSYVTRWLYSTSHKDIGMTYLGFGMLSAMMGTGMSVMMRMELSNGNSQFFHGNNQAFNVMMSGHALLMMFFFIMPVWMGAFGNFFLPMLMGAADMAFARLNNISFWCLPPALVCMVCSVLMEQGAGTGFTTYPPLSSMSAHSGPSVDLAMFAMHLTSMSSLLGAMNFMVTVLNMRTMGLHMVNMPLFAWAMFLTAMLLLLSLPVLTAAVTLLLMDRNFNTGFYEVGAGGDPVTYEHLFWFFGHPEVYILMMPGFGVMSHMVSTYSKKPMFGEMGMLYAMGSIGFLGFLVWSHHMFVVGLDIDSRAYFTSATMVIAVPTGIKIFSWLATIYGGELRLGVPMLFALGFLFLFTMGGLTGVMTSNASMDVAFHDTYYVVGHFHYVLSMGALFSLMGAYYYWGPAMFGLKYNRMLGEMHFWLLFMSVNVMFLPMHFLGLNGMPRRMPQYPDAFMGWNYMSSMGSAMSVMSVLVGLKSVLVQLENGENEELEMQVTPDFTESNLNREIRDSDLDLILTRPAEYHTYSELPVLTSNSHA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TRBJ_RHIRD
Sequence: MPIHSSRPTRLARHAMIAAILLSSTSPMPAVAGGVTGQATEWTQLANNTELISLVGKSAEQVNNQITQISQLAEQIQNQLNIYRNMLQNTAQLPNHIWGQVENDLKNLQNVVNEGQGVAFSMGNVEDVMKQRFQSFAEMKSNLPDGASFSTTYQNWSGTNRDTIAGTLKAANLTSEQFSSEESTMSSLRSMSESSDGQMKALQVGHQIAAQQVAQMQKLRGLVSQQMTMMGTWYQSEQAQKDLAQARREQFFSGTEHDIRGGQTMEPRW
What are the official names of this protein?
Conjugal transfer protein TrbJ.
Protein: MNMA_HELPY
Sequence: MKIAVLLSGGVDSSYSAYSLKEQGHELVGIYLKLHASEKKHDLYIKNAQKACEFLGIPLEVLDFQKDFKSAVYDEFINAYEEGQTPNPCALCNPLMKFGLALDHALKLGCEKIATGHYARVKEIDKISYIQEALDKTKDQSYFLYALEHEVIAKLVFPLGDLLKKDIKPLALNAMPFLGTLETYKESQEICFVEKSYIDTLKKHVEVEKEGVVKNLQGEVIGTHKGYMQYTIGKRKGFSIKGALEPHFVVGIDAKKNELVVGKKEDLATHSLKAKNKSLMKDFKDGEYFIKARYRSVPAKAHVSLKDEVIEVGFKEPFYGVAKGQALVVYKDDILLGGGVIV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_BART1
Sequence: MKRTYQPSKLVRKRRHGFRARMATAGGRKVIAARRARGRKRLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: LSRB_SALPB
Sequence: MARHSIKMIALLTAFGLASAVMTVQAAERIAFIPKLVGVGFFTSGGNGAQEAGKALGIDVTYDGPTEPSVSGQVQLVNNFVNQGYDAIIVSAVSPDGLCPALKRAMQRGVKILTWDSDTKPECRSYYINQGTPKQLGSMLVEMAAHQVDKEKAKVAFFYSSPTVTDQNQWVKEAKAKISQEHPGWEIVTTQFGYNDATKSLQTAEGIIKAYPDLDAIIAPDANALPAAAQAAENLKRNNLAIVGFSTPNVMRPYVQRGTVKEFGLWDVVQQGKISVYVANALLKNMPMNVGDSLDIPGIGKVTVSPNSEQGYHYEAKGNGIVLLPERVIFNKNNIDKYDF
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
What are the official names of this protein?
Autoinducer 2-binding protein LsrB, AI-2-binding protein LsrB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 2 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RF2_KLEP3
Sequence: MFEINPVKNRIQDLTERSDVLRGYLDYDAKKERLEEVNAELEQPDVWNEPERAQALGKERSSLEAIVDTLDQMSQGLEDVAGLLELAVEAEDEETFNEAVAELDGLEEKLAQLEFRRMFSGEYDSADCYLDIQAGSGGTEAQDWASMLMRMYLRWAEARGFKTEIIEESEGEVAGIKSVTIKIIGDYAYGWLRTETGVHRLVRKSPFDSGGRRHTSFSSAFVYPEVDDDIDIEINPADLRIDVYRASGAGGQHVNRTESAVRITHIPTGLVTQCQNDRSQHKNKDQAMKQMKAKLYELEMQKKNAEKQAMEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVETRNTQAVLDGSLDQFIEASLKAGL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CITM_BACSU
Sequence: MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFTEVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGTAVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGATPRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEPAAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQRQRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVALTSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHLLVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV
What is the function of this protein?
Proton motive force-driven secondary transporter that mediates the transport of citrate complexed to Mg(2+).  Cotransports at least two protons per Mg(2+)-citrate complex.  Can also transport citrate in complex with Ni(2+), Mn(2+), Co(2+), and Zn(2+).
What are the official names of this protein?
Mg(2+)/citrate complex secondary transporter.
What is the protein family that this protein belongs to?
Belongs to the CitM (TC 2.A.11) transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSCB_KLEP7
Sequence: MDYFTLFGLPASYTLSLEQLAVRYQDLQRQYHPDKFASAPAAEQLAAVQHSATINQAWQTLRHPLTRAEYLLSLHGFDLASEQHTVRDTAFLMEQLELREELDEIGQAKDDARLEGFIKRVKALFDTRQQLMVDQLHNESWEAAADTVRKLRFLDKLRSSAEELEEKLLDF
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: LON2_THET2
Sequence: MLPETMPVCPVRGSVIYPTMVMPIDAGRPISIRAIDEALARDRVLLIVSQRDKEVETPRPSDLFEVGTACNILKMRKNPDGSVQVLVQAFARVRVREWLDLGDHLEARGEVLADEPGEPILVKALVREVKDKFQALLKEGKYLAPEVAQFILNLEDPSQLADYVAFHMDFRLEDKQKVLETANVAERLRAVLVLLEAELALIETQRRIQQQVKEEIDRNQREYFLREQMKAIQRELHGEEGEQEVEEFRRKLEALDLPPVVRQEVERELNRFARMHPDSAEASVIRTYLDWIVNLPWNTRTEDNLDLERAKEILERDHYGLEKVKDRVLEYLAVRKLKAERAKRGEIPPDEVNKGPILLFVGPPGVGKTSIAKSIAEALGRKYVRVSLGGVRDESDIRGHRRTYIGAMPGRIIQGLRQAGTKNPVFLLDEVDKLGISYQGDPAAALLEVLDPAQNKEFVDHYLGVPFDLSEVMFICTANFPQNIPAPLYDRMEPIEFTSYTEQEKLEIAKRYLLPRQLKENGLEPEQVVVTEAALTRLITHYTREAGVRQLEREIGALLRKAARRILEEGKKRVRITEKDLEAYLGPPRFLPETEAREPQVGVATGMYYTPVGGDIMFVEVSVMPGKGNLILTGQLGDVMKESARAALSYAKKNALRFGIPLEKFDKSDIHIHVPAGAIPKEGPSAGVALVSALVSALTEVPVRHDIAMTGEITLTGRVLPIGGVKEKVLGARRAGIREVILPKLNEPDLADIPKPLRQNMTFHFVEHLDQVLDLALVGGLKALEERGRRSRSARRKKELVAHA
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease 2, ATP-dependent protease La 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLKL_HUMAN
Sequence: MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
What is the function of this protein?
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671).  Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671).  Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671).  In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity).  Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
What are the official names of this protein?
Mixed lineage kinase domain-like protein, hMLKL.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Nucleus. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity).
Protein: IDI_ECO8A
Sequence: MQTEHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPNGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQAANSEARKLLSAFAQHN
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMPP_METBU
Sequence: MKHIIFTDLDGTLIDHDTYSYDAARPALDLLKEKEIPLIFCTSKTRAELEVYVDELECHHPFISENGGAIFIPKDHFSIELKDVHEIGNYKVIEFGTSYTRIRGVLEDIRKKTGFKITGFGDLDAEGVSKDTGLDIRSAKLAKLREYDEAFRLEEDENATAKVIELIHAAGLNYTKGGRYWHIMGDNDKGKAVRALTEIYRQQFTEVVTIALGDSLNDLPMLKAVDIPFLVQKPDGKYDPSIILTEIKHAEGIGPVGWNNAIMDLIGKNNNI
What is the function of this protein?
Involved in the biosynthesis of glucosylglycerate.  Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) and mannosyl-3-phosphoglycerate (MPG) to glucosylglycerate (GG) and mannosylglycerate (MG), respectively.
What are the official names of this protein?
Glucosyl-3-phosphoglycerate/mannosyl-3-phosphoglycerate phosphatase, GpgP, MpgP.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MPGP family.
Protein: CMOB_EDWI9
Sequence: MIDFGNFYAQIAHGPLSKWLEVLPAQLAAWQRDSLHGYFRDWNNAVERLPALTPHRLDLLHGVCAGAETPLSEGQRIGIEKMLRTLMPWRKGPFELYGIQIDTEWRSDWKWQRILPHLSPLAGRTILDVGCGSGYHLWRMVGAGAHLAVGIDPMQLFLCQFEAVRKLLGGDSRAHLLPLGIEQLPALAAFDTVFSMGVLYHRRSPLDHLYQLKNQLVSGGELLLETLVIEGDEQQALIPGERYAQMRNVYFIPSAAMLIRWLEKCGFCDVRLVDQCPTSVEEQRRTDWMTSESLADFLDPADVRKTLEGYPAPLRAAFIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: STRBP_HUMAN
Sequence: MRSIRSFANDDRHVMVKHSTIYPSPEELEAVQNMVSTVECALKHVSDWLDETNKGTKTEGETEVKKDEAGENYSKDQGGRTLCGVMRIGLVAKGLLIKDDMDLELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCVNEASIIIRNTKEPTLTLKVILTSPLIRDELEKKDGENVSMKDPPDLLDRQKCLNALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPLELICEKSIGTCNRPLGAGEALRRVMECLASGILLPGGPGLHDPCERDPTDALSYMTIQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSSKPFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKKMKRNLRKILDSKAIDLMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASGPSKKTAKLHVAVKVLQAMGYPTGFDADIECMSSDEKSDNESKNETVSSNSSNNTGNSTTETSSTLEVRTQGPILTASGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNKKVAKASAALAALEKLFSGPNAANNKKKKIIPQAKGVVNTAVSAAVQAVRGRGRGTLTRGAFVGATAAPGYIAPGYGTPYGYSTAAPAYGLPKRMVLLPVMKFPTYPVPHYSFF
What is the function of this protein?
Involved in spermatogenesis and sperm function.  Plays a role in regulation of cell growth.  Binds to double-stranded DNA and RNA.  Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA.  Binds also to single-stranded poly(G) RNA.  Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).
What are the official names of this protein?
Spermatid perinuclear RNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm. Note=Microtubule- associated that localizes to the manchette in developing spermatids.
Protein: YIDC_MYCPU
Sequence: MKRENRSKKYDYFNSSSNNSNKFSKTNFKKYFKIFKLVVYIFLIGLALTGCIQSFVVQSSPNVGAGLELYPSKDKVAPRVNVYKKEENGYVKDRNINELLKDEQSLQALKDFSKNHNGVYGKTKSSNSALAILEDNTYIDSDGQENKSIIYKDNSGKYLFFNDTLTTYDPINKFTDIYAIGRLTERDSDAIKFRENNPKIIEHLKLFKVSEVPISREYQPNIKFARDFLQALYDKTLKLPVYQNILRADGSKYASFNEFLTSLEKRTTNHLKTQLNKQELSEEDLNSITLSDSESAALNAYLTRVNPLISENGFTGLKKSLNNADDFELVYSQGEKIAQSDYGQIPVVTWGEYWNYGPFYALLVAPIASFTNWVASAFESGFGIVFAIIVVVVVTRLFIFGLTFKVTFSQYKQQELQGKKAKIDAKYAAYENNKMMKQRKQKEIQDLYKKHNISPIDFVASIAWSSPLFIAVWRVIQSVPVIKSNFFLGVNFSTASYQEILAKNWVYLWVVSLALIVQIISQILPRWLAKKKIKERANVYEMQSYKKNNKTQNIMLIVFMVFTITLQAGVQIYWIIGGLWTIGQTLFVHHFQKTSFFKNRVRPWLDRH
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NAC1_RAT
Sequence: MLRLSLPPNVSMGFRLVTLVALLFTHVDHITADTEAETGGNETTECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPASKTEIEMDGKVVNSHVDNFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNMDVVENDPVSKVFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVIFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVRVSSEVSEDGILDSNHVSAIACLGSPNTATITIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIIPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFIEIGEPRLVEMSEKKALLLNELGGFTLTEGKKMYGQPVFRKVHARDHPIPSTVISISEEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSSLFVLLWLLYIFFSSLEAYCHIKGF
What is the function of this protein?
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8422940, PubMed:8454039, PubMed:10894800, PubMed:12502557).  Contributes to Ca(2+) transport during excitation-contraction coupling in muscle.  In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum.  SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline.  Required for normal embryonic heart development and the onset of heart contractions (By similarity).
What are the official names of this protein?
Sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1, Solute carrier family 8 member 1.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
Protein: ISPH_YERPY
Sequence: MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEISEVPDGSILIFSAHGVSQAVRAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILIGHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDENNLCFMTQTTLSVDDTSAVIDALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMGKPAYLIDSAADIQEFWLQGAQCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREENIVFEVPKELRVEVKQID
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.