PharMolix/UniProtQA huggingface dataset:
Protein: GAPD1_MOUSE
Sequence: MVKLDIHTLAHHLKQERLYVSSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPAQQEKLFGEKGSDRFRQKVQEMVDSNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGTEEGDPRTKNSLGKFDKGCVAAFLDVVIGGRAVETPPMSSVNLLEGLSRTVVYISYSQLITLVNFMKSVMSGDQLKEDRMALDNLLANLPQAKPGKSSSLDMTPYSTPQMSPATTPANKKNRLPIATRSRSRSNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNVDEDRLQEIAGAAAENVLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDDIAHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTAAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEELPPAAATGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDERSDRSRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDEPSPRLSAQAQVAEDILDKYRNAIKRTSPSEGAMANDESAEVMGDGESAHDSPREEALQNISADDLPDSASQAAHPQDSAFSYRDVKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKSLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGVMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
What is the function of this protein?
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking.  Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking.  In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells.  Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles.  Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome.  Has GEF activity for Rab5 and GAP activity for Ras.
What are the official names of this protein?
GTPase-activating protein and VPS9 domain-containing protein 1, GAPex-5, Rab5-activating protein 6.
What is the protein family that this protein belongs to?
Belongs to the GAPVD1 family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Endosome. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.
Protein: OR1D5_PANTR
Sequence: MDGDNQSENSQFLLLGISESPEQQQILFWMFLSMYLVTVLGNVLIILAISSDSRLHTPMYFFLANLSFTDLFFVTNTIPKMLVNLQSQNKAISYAGCLTQLYFLVSLVTLDNLILAVMAYDRYVAICCPLHYVTAMSPGLCVLLLSLCWGLSVFYGLLLTLLLTRVTFCGPREIHYLFCDMYILLRLACSNTHIIHTVLVATGCFIFLTPLGFMTTSYVRIVRTILQIPSASKKYKAFSTCASHLGVVSLFYGTLAMVYLQPLHTYSMKDSVATVMYAVVTPMMNPFIHSLRNKDMHGALGRVLRRLFQRPK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1D5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y675_MYCPN
Sequence: MGFYGNLNHMEKGKSGYVTHKQLDKKLEVFKQELLVEFDQRYVTKAEFKEFQIEVREGFRIQGEAMNARMDRFESLVLKSLESINNTLIDFGKRIDKLESK
What are the official names of this protein?
UPF0134 protein MPN_675.
What is the protein family that this protein belongs to?
Belongs to the UPF0134 family.
Protein: MNME_UREPA
Sequence: MSTIVALATAPMNCAIHIIRVSGPKAFEIINKISTIKIKKETFKIWYTILKDDNQILDEVLINTFVAPKTFTGEDLVEINCHGGIVVANLIIKTLIKYGCQPAQRGEFSRRALLNKKMDLSKIEAINNLVNAKNELSVKGVIGALLGRVSQSIAEFRHELFMIIGQIEVNIDYPEYDDVEQVDAIILKQRLLSLDKKITKIIDQSKKFLPINKGIRVLIIGKPNVGKSTLLNALCNEQKAIVTDIPGTTRDVIESSINIDNITLNILDTAGIHLTNDFVENLGINKAKALIDKVDLILYLIPANEQQDLELYDLIKKQKHLLVYTKKDLVDQYDDKQIYINAKNNDIQSLIDEIKKLFYVQEFDNANIDVLQSQRQIGILENVHYLINNAILNLEKGDTLDLIVADLEFCNLRLNELLGISSEYDFLDDLFKNFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_PHOPR
Sequence: MNIQALINDKVSQALEAAGAPAGSPAAVRQSAKIQFGDYQANGVMGVAKKLGTNPREFAQKVIDVLDLDGIAEKVEIAGPGFINIFLDKSWLAARAEEALTDDRIGVAAEKQQNIVVDYSAPNVAKEMHVGHLRSTIIGDAVVRTLEFLGHNVVRANHIGDWGTQFGMLIANLERVQNETGEVSMELADLEGFYRESKKLYDEDEEFAVRARAFVVKLQSGDEYCAEMWKKLVDVTMVQNQINYDRLNVSLTRDNVMGESMYNYMLPGIVADLKEKGLAVESDGAQVVFLDEYKNKDGDPMGVIIQKRDGGFLYTTTDIACAKYRFEQLNADRVLYFIDSRQHQHLMQAWSIVRKAGYVPEEVTLEHHAFGMMLGKDGRPFKTRAGGTVRLADLLDESEVRAAKLIEAKNPDLDTAEKDKIAKTVAMAAVKYADLSKHRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVASIFKRADVNLADLTHPIVINDEKEQALLSTLLQFEEAVLNVSREGQPHLMCTYLFELAGKFSSFYEACPILNAEEAVKQSRLKLALLTAKTIKQGLDLLGIETLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_ACIBT
Sequence: MKVQQYRLDELAHLVKGELIGEGSLQFSNLASLENAEVNHLTFVNGEKHLDQAKVSRAGAYIVTAALKEHLPEKDNFIIVDNPYLAFAILTHVFDKKISSTGIESTAQIHPSAVISETAYIGHYVVIGENCVVGDNTVIQSHTKLDDNVEVGKDCFIDSHVTITGGSKLRDRVRIHSSTVIGGEGFGFAPYQGKWHRIAQLGSVLIGNDVRIGSNCSIDRGALDNTILEDGVIIDNLVQIAHNVHIGSNTAIAAKCGIAGSTKIGKNCILAGACGVAGHLSIADNVTLTGMSMVTKNISEAGTYSSGTGLFENNHWKKTIVRLRQLADVPLTQITKRLDHIQAQIESLESTFNLRK
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: GPDA_BORPE
Sequence: MSQARPATLRVAVLGAGSWGTALAAAASRRHPTVLWARDGAQAQAMAARHENTRYLPGVALPHALQVSADLAQALAHLAHDPAHALIILGVPVAGMTPLCTELAARLPALGLQAVPLVWTCKGFEEQTARLPHETVQAALGAMPGLAAGVLSGPSFAREVAQGLPVALTVASGSSAVRDAVTTALHGAAVRIYASTDVVGVEVGGALKNVIAVACGICDGLALGTNARAALITRGLAEMARFGAALGAQQETFAGLTGLGDLVLTATGELSRNRRVGLEIGAGRKLADILASGMTAEGVRCARAARDRARALNIELPITEAVCAVLFEGLSPMTAVSALLAREARPESPTP
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECU_GEOSW
Sequence: MIFKYPGGKTYETKQMNKSIRPFQPNYGNRGMTLEEDLNATNEYYREHGIAVIHKKPTPVQIVRVDYPKRSAAVIKEAYFKQASTTDYNGVYRGKYIDFEAKETKNKTSFPLKNFHEHQIHHMQQVLRHGGICFVILRFTTLNEVYLLDANHLIMFWEQQRSGGRKSIPKREIERYGHYIALGYQPRIDYISVVEKVYFSH
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGGU_ECO57
Sequence: MSAVTVNDDGLVLRLYIQPKASRDSIVGLHGDEVKVAITAPPVDGQANSHLVKFLGKQFRVAKSQVVIEKGELGRHKQIKIINPQQIPPEVAALIN
What are the official names of this protein?
UPF0235 protein YggU.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: ITRF_MAIZE
Sequence: MASSSSSSHRRLILAAAVLLSVLAAASASAGTSCVPGWAIPHNPLPSCRWYVTSRTCGIGPRLPWPELKRRCCRELADIPAYCRCTALSILMDGAIPPGPDAQLEGRLEDLPGCPREVQRGFAATLVTEAECNLATISGVAECPWILGGGTMPSK
What is the function of this protein?
Potent inhibitor of mammalian trypsin and a specific inhibitor of factor XIIa (activated hageman factor).
What are the official names of this protein?
Trypsin/factor XIIA inhibitor, CHFI, Hageman factor inhibitor.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I6 (cereal trypsin/alpha-amylase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: SC22A_RAT
Sequence: MSMILSASVVRVRDGLPLSASTDCEQSAGVQECRKYFKMLSRKLAQFPDRCTLKTGRHNINFISSLGVSYMMLCTENYPNVLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQRTKQRYNNPRSLSTKINLSDMQMEIKLRPPYQIPMCELGSANGVTSAFSVDCKGAGKISSAHQRLEPATLSGIVAFILSLLCGALNLIRGFHAIESLLQSDGEDFSYMIAFFLGTAACLYQCYLLVYYTSWRNVKSFLTFGLICLCNMYLYELRNLWQLFFHVTVGAFVTLQIWLRQAQGKAPDHDV
What is the function of this protein?
May be involved in vesicle transport between the ER and the Golgi complex.
What are the official names of this protein?
Vesicle-trafficking protein SEC22a, SEC22 vesicle-trafficking protein homolog A, SEC22 vesicle-trafficking protein-like 2, rSec22a.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GATC_RICAE
Sequence: MITKEEAQKIAKLARLKFEEDTVEKFFTQLSTIMDMIDILNEIDCKDIEPLTSVCNMNARMREDAVTSSDLSSELFDNVSGNSTQLAKEVKYFITPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: MS18B_HUMAN
Sequence: MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEPAAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN
What is the function of this protein?
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
What are the official names of this protein?
Protein Mis18-beta, Cancer/testis antigen 86, CT86, Opa-interacting protein 5, OIP-5.
What is the protein family that this protein belongs to?
Belongs to the mis18 family.
Protein: RECF_LEPIC
Sequence: MFLKHLTIQNFRNHEELSLDFDSRLIFFVGDNGEGKTNLLEAICILSWLKSFRESEDSNLIRWGSENYFLRGKIKNNLKESVLEIGFTSKPSVKRKLKFNQEEIKKRTDLIGKFITVLLTPMDLKIIEGGPAERRKFIDAFISSFDPFYLEFLLEYNKILKHRNALLKSGNLDISHLSIWDKKIVEKGIFILNKRREVVLELNSFYRVNLDKLSGGKDGLELIYKPNVKDQDEFLEKLNRNLSRDLRLGYTSVGIHRDDLFIGTDQRDITEFGSQGQKRSTVIALKAATFNYYKDILNTIPVLLIDDVIRELDVKRREYFVDLVVTAGQAFFTTTDLEGIQDYVGKLKDQKQIFLIRQGKVEPIK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPTC1_MOUSE
Sequence: MATVAEQWVLVEMVQALYEAPAYHLILEGILILWIIRLVFSKTYKLQERSDLTAKEKEELIEEWQPEPLVPPVSKNHPALNYNIVSGPPTHNIVVNGKECVNFASFNFLGLLANPRVKATAFSSLKKYGVGTCGPRGFYGTFDVHLDLEERLAKFMKTEEAIIYSYGFSTIASAIPAYSKRGDIIFVDSAACFAIQKGLQASRSDIKLFKHNDVADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPDIFAVLKKKCQNIHKSLQGVSGLKVVGESLSPALHLQLEESTGSREKDVKLLQAIVDQCMDKGIALTQARYLDKEEKCLPPPSIRVVVTVEQTEEELQRAASTIREAAQAVLL
What is the function of this protein?
Serine palmitoyltransferase (SPT) (PubMed:28100772).  The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core.  The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference.  The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates.  The SPTLC1-SPTLC2-SPTSSB complex displays a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme has the ability to use a broader range of acyl-CoAs (By similarity).  Required for adipocyte cell viability and metabolic homeostasis (PubMed:28100772).
What are the official names of this protein?
Serine palmitoyltransferase 1, Long chain base biosynthesis protein 1, LCB 1, Serine-palmitoyl-CoA transferase 1, SPT 1, SPT1.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: NRL2_RHORH
Sequence: MVEYTNTFKVAAVQAQPVWFDAAKTVDKTVSIIAEAARNGCELVAFPEVFIPGYPYHIWVDSPLAGMAKFAVRYHENSLTMDSPHVQRLLDAARDHNIAVVVGISERDGGSLYMTQLVIDADGQLVARRRKLKPTHVERSVYGEGNGSDISVYDMPFARLGALNCWEHFQTLTKYAMYSMHEQVHVASWPGMSLYQPEVPAFGVDAQLTATRMYALEGQTFVVCTTQVVTPEAHEFFCDNDEQRKLIGRGGGFARIIGPDGRDLATPLAEDEEGILYADIDLSAITLAKQAADPVGHYSRPDVLSLNFNQRHTTPVNTAISTIHATHTLVPQSGALDGVRELNGADEQRALPSTHSDETDRATASI
What are the official names of this protein?
Aliphatic nitrilase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Protein: Y236_METTH
Sequence: MVFMLEDIYERIVRIREEGCRECLKVVCRMDDFQFNQLMSRLDLQIEITSRYSPPVRPALDPMISTELGVYRGDDENIGRLLGYPECCIRSFSENTRYAIDGEHLAEVSELDIPEGKCAIIMPSGFIPCSLRCQEAWERKLIGFADRDEFRRILELEDELMMRLPHFHLAYDEYFEKIVLE
What are the official names of this protein?
Uncharacterized protein MTH_236.
What is the protein family that this protein belongs to?
To M.jannaschii MJ1106.
Protein: RDRP_I01A2
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEKSHPGIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKGEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRKQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTS
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: SGF73_YEAST
Sequence: MRSGDAEIKGIKPKVIEEYSLSQGSGPSNDSWKSLMSSAKDTPLQYDHMNRESLKKYFNPNAQLIEDPLDKPIQYRVCEKCGKPLALTAIVDHLENHCAGASGKSSTDPRDESTRETIRNGVESTGRNNNDDDNSNDNNNDDDDDDDNDDNEDDDDADDDDDNSNGANYKKNDSSFNPLKRSTSMESANTPNMDTKRSKTGTPQTFSSSIKKQKKVKQRNPTEKHLIDFNKQCGVELPEGGYCARSLTCKSHSMGAKRAVSGRSKPYDVLLADYHREHQTKIGAAAEKRAKQQELQKLQKQIQKEQKKHTQQQKQGQRSKQRNVNGGKSAKNGGKSTVHNGNNINEIGHVNLTPEEETTQVLNGVSRSFPLPLESTVLSSVRYRTKYFRMREMFASSFSVKPGYTSPGYGAIHSRVGCLDLDRTTDYKFRVRTPQPINHLTNQNLNPKQIQRLQQQRALQAQLLSQQQQQQQQQQQHHSPQAQAQASTQQPTQGMVPNHFPGGATNSSFNANVSSKQIQQQQQQQQHKSQDTGLTPLEIQSQQQKLRQQQLQQQKFEAAASYLANATKLMQESNQDSHLSGTHNNNSSKNGNNNLMTMKASISSPNTSVNSIQSPPSVNSVNGSGQGVSTGINVSGNNGRIEVGIGNSVNPYNGRIN
What is the function of this protein?
Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA.  SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes.  At the promoters, SAGA is required for recruitment of the basal transcription machinery.  It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8).  SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac).  SAGA interacts with DNA via upstream activating sequences (UASs).
What are the official names of this protein?
SAGA-associated factor 73, 73 kDa SAGA-associated factor, SAGA histone acetyltransferase complex 73 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the ataxin-7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TPMT_HORSE
Sequence: MDGTRTVLDIKEYSDSEVQKNRVLTLEEWQGKWVTGKTIFHQEQGHQLLKKHLDAFLKGESGLKVFFPLCGKAVEMKWFADRGHSVVGVEISELGIREFFTEQNLSYSEEPIIEIPGAKVFKSSSGNISLYCCNIFDLPRTNIGKFDRIWDRGALVAVNPGDRKRYVDIMLSLTRKGFHYLLAVLSYDPTKHAGPPFFVSDAEVKRLFDSVCNIRCLEKVDALEERHKSWGIDYLVETLYLFTEK
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_ALKCK
Sequence: MSKESIYGLTMAQLTDWLMERGHKKFRATQVWDWLYRKRVTTFAEMTNVNKDCLQLLEDHFAIETMSEHVRQESKDGTIKFLFRLQDGNLIETVLMRHKYGFSVCVTTQVGCNIGCSFCASGLLTKNRDLSSGEIVEQIMKVQFHLDQVGKEERVSHVVVMGIGEPFDNFQNTVDFLEIIKDHKGLAIGARHITVSTSGLAHKIYEFADLKLQVNLAVSLHAPNNELRSRIMKINKAFPIEKLMDSINYYIEKTNRRVTYEYILIKDVNDHKEEALQLAELIGDKRHLSYVNLIPYNPVDEHSQYQRSEPEAISQFFDTLKKKGINCGVRLEHGTDIDAACGQLRSKQEKKKVKVN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPT_BACTN
Sequence: MGLLQEKLAKYDLPQKFMAQGVYPYFREIEGKQGTEVEMGGQHVLMFGSNAYTGLTGDERVIEAGIKAMRKYGSGCAGSRFLNGTLDLHVQLEKELAAFVGKDEALCFSTGFTVNSGVISCLTDRNDYIICDDRDHASIVDGRRLSFSQQLKYKHNDMADLEKQLQKCNPDSVKLIIVDGVFSMEGDLANLPEIVRLKHKYNATIMVDEAHGLGVFGKQGRGVCDHFGLTHEVDLIMGTFSKSLASIGGFIAADSSIINWLRHNARTYIFSASNTPAATAAALEALHIIQNEPERLNALWEATNYALRRFREAGFEIGATESPIIPLYVRDTEKTFMVTKLAFDEGVFINPVIPPACAPQDTLVRVALMATHTKEQIDSAVEKLVKAFKALDLL
What is the function of this protein?
Involved in de novo bacterial ceramide synthesis (PubMed:35667415, PubMed:32424203, PubMed:31071294, PubMed:35080445, PubMed:35725777).  Catalyzes the condensation of L-serine with palmitoyl-CoA (hexadecanoyl-CoA) to produce 3-oxosphinganine (PubMed:35667415).  Also capable of using alanine as substrate leading to the formation of 1-deoxysphinganine (1-deoxySa) (PubMed:31071294).  Contributes to the levels of endogenous sphingolipids in its host (PubMed:32424203, PubMed:31071294).
What are the official names of this protein?
Serine palmitoyltransferase, SPT, BtSPT.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: NU1C_LEPVR
Sequence: MIIYATAVQTINSFVRLESLKEVYGLIWIFVPIFSLVLGIITGVLVIVWLEREISAGIQQRIGPEYAGPLGILQALADGTKLLFKENLRPSRGNTPLFSIGPSIAVISILLSYSVIPFSNHLVLADLNIGIFLWIAISSIAPIGLLMSGYGSNNKYSFLGGLRAAAQSISYEIPLTLCVLSISLLSNSLSTVDIVEAQSKYGFWGWNLWRQPIGFIIFLISSLAECERLPFDLPEAEEELIAGYQTEYSGIKFGLFYVASYLNLLISSLFVTVLYLGGWNISIPYISILELFQRDQIFGTTIGIFITLAKTYLFLFISIATRWTLPRLRMDQLLNLGWKFLLPISLGNLLLTTSFQLFSL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PP297_ARATH
Sequence: MYRFLGLTIHGGLIKRGLDNSDTRVVSASMGFYGRCVSLGFANKLFDEMPKRDDLAWNEIVMVNLRSGNWEKAVELFREMQFSGAKAYDSTMVKLLQVCSNKEGFAEGRQIHGYVLRLGLESNVSMCNSLIVMYSRNGKLELSRKVFNSMKDRNLSSWNSILSSYTKLGYVDDAIGLLDEMEICGLKPDIVTWNSLLSGYASKGLSKDAIAVLKRMQIAGLKPSTSSISSLLQAVAEPGHLKLGKAIHGYILRNQLWYDVYVETTLIDMYIKTGYLPYARMVFDMMDAKNIVAWNSLVSGLSYACLLKDAEALMIRMEKEGIKPDAITWNSLASGYATLGKPEKALDVIGKMKEKGVAPNVVSWTAIFSGCSKNGNFRNALKVFIKMQEEGVGPNAATMSTLLKILGCLSLLHSGKEVHGFCLRKNLICDAYVATALVDMYGKSGDLQSAIEIFWGIKNKSLASWNCMLMGYAMFGRGEEGIAAFSVMLEAGMEPDAITFTSVLSVCKNSGLVQEGWKYFDLMRSRYGIIPTIEHCSCMVDLLGRSGYLDEAWDFIQTMSLKPDATIWGAFLSSCKIHRDLELAEIAWKRLQVLEPHNSANYMMMINLYSNLNRWEDVERIRNLMRNNRVRVQDLWSWIQIDQTVHIFYAEGKTHPDEGDIYFELYKLVSEMKKSGYVPDTSCIHQDISDSEKEKLLMGHTEKLAMTYGLIKKKGLAPIRVVKNTNICSDSHTVAKYMSVLRNREIVLQEGARVHHFRDGKCSCNDSW
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At4g01030, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TRMB_BRADU
Sequence: MSERKSDPDRDDSERAFFGRRKGHKLRQHQAELIDHLLPHLALDIAGEAPGNACEIFDPAASDVRLEIGFGGGEHLAAEAQNFATTGFIGCEPYVNGMAKILAQIEAGNIANIRLFAGDAAELLAWLPKASLSRIDLIHPDPWPKRRHWKRRFVQDRTIAAMARVLKVGGEFRFVCDIDDYCAWTLSHLARSADFKWLAERADDFRQPWDGYTMTRYGRKAAREGRKAAYLRFRRS
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RL24_ENT38
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKIIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVALFNTVTGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.