PharMolix/UniProtQA huggingface dataset:
Protein: RL21_STRPB
Sequence: MSTYAIIKTGGKQVKVEVGQAIYVEKIDAEAGAEVTFNEVVLVGGDKTVVGTPVVEGATVVGTVEKQGKQKKVVTFKYKPKKGSHRKQGHRQPYTKVVINAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RS12_CLOBL
Sequence: MPTISQLVRKGRKTIASASDSPALKECPQKRGVCTVVKTTTPKKPNSALRKVARIRLTNGYEVTAYIPGVGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDAAGVANRMQSRSKYGAKKPKQK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RSMH_PROA2
Sequence: MEHDGYHLPVMVSEVTDLLARRPGIYIDGTLGGGGHAFSVMSALRRSGFENDSLLIGIDQDSFALEEAAGRLRPFASRVRLERGNFSEMAAIIERIRLREGCRLPVMGILLDLGVSSFQIDTPDRGFSYLRQGPLDMRMDPDGGWSAADIVNTAEESELAGIIYRYGEEKKSRAIARAIKARVREKGDFRETAELAAVVRSVVAGHDRQIKSLSRVFQALRIAVNDELGVLESALEDGTACLAPSGRMGVMSYHSLEDRMVKRFFRDKSEDDWGPKGVGLREPLRSAGFKLVTRKSVVASDDEVRINPRARSARLRVIEKKELEGESHDRVYQ
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFI_SALEP
Sequence: MDLASLRAQQIELASSVCREDRLDKDPPAFIGGADVGFEQGGEVTRAAMVLLKYPSLELVEYKVARIATTMPYIPGFLSFREYPALLAAWEQLSQKPDLLFVDGHGISHPRRLGVASHFGLLVDVPTIGVAKKRLCGKFEPLSTEPGALSPLMDKGEQLAWVWRSKARCNPLFIATGHRVSTDSALAWVQRCMKGYRLPEPTRWADAVASGRPAFVRWQEIQR
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRLR_ECOLI
Sequence: MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKELIAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQALEEKGIDVIITGESNE
What are the official names of this protein?
Glucitol operon repressor.
Protein: DTX3L_HUMAN
Sequence: MASHLRPPSPLLVRVYKSGPRVRRKLESYFQSSKSSGGGECTVSTQEHEAPGTFRVEFSERAAKERVLKKGEHQILVDEKPVPIFLVPTENSIKKNTRPQISSLTQSQAETPSGDMHQHEGHIPNAVDSCLQKIFLTVTADLNCNLFSKEQRAYITTLCPSIRKMEGHDGIEKVCGDFQDIERIHQFLSEQFLESEQKQQFSPSMTERKPLSQQERDSCISPSEPETKAEQKSNYFEVPLPYFEYFKYICPDKINSIEKRFGVNIEIQESSPNMVCLDFTSSRSGDLEAARESFASEFQKNTEPLKQECVSLADSKQANKFKQELNHQFTKLLIKEKGGELTLLGTQDDISAAKQKISEAFVKIPVKLFAANYMMNVIEVDSAHYKLLETELLQEISEIEKRYDICSKVSEKGQKTCILFESKDRQVDLSVHAYASFIDAFQHASCQLMREVLLLKSLGKERKHLHQTKFADDFRKRHPNVHFVLNQESMTLTGLPNHLAKAKQYVLKGGGMSSLAGKKLKEGHETPMDIDSDDSKAASPPLKGSVSSEASELDKKEKGICVICMDTISNKKVLPKCKHEFCAPCINKAMSYKPICPTCQTSYGIQKGNQPEGSMVFTVSRDSLPGYESFGTIVITYSMKAGIQTEEHPNPGKRYPGIQRTAYLPDNKEGRKVLKLLYRAFDQKLIFTVGYSRVLGVSDVITWNDIHHKTSRFGGPEMYGYPDPSYLKRVKEELKAKGIE
What is the function of this protein?
E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272).  Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742).  In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714).  The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714).  PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272).  By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788).  Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097).  In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097).  In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788).
What are the official names of this protein?
E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein, Protein deltex-3-like, RING-type E3 ubiquitin transferase DTX3L, Rhysin-2, Rhysin2.
What is the protein family that this protein belongs to?
Belongs to the Deltex family.
Protein: VNB_INBUS
Sequence: MNNATFNHTNVNPISHIRGSVIITICVSFTVILTVFGYIAKIFTNKKNCTNNVIGLRERIKCSGCEPFCNKRDDISSPRTGVDIPSFILPGLNLSESTPN
What is the function of this protein?
Putative viral proton channel.  May play a role in virus entry (By similarity).
What are the official names of this protein?
Glycoprotein NB.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses type B glycoprotein NB family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type III membrane protein.
Protein: RN128_HUMAN
Sequence: MGPPPGAGVSCRGGCGFSRLLAWCFLLALSPQAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSVAVDVIPHVDNPTFEEDETPNQETAVREIKS
What is the function of this protein?
E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation.  Functions as an inhibitor of cytokine gene transcription.  Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production.  Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse.  Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF128, Gene related to anergy in lymphocytes protein, GRAIL, RING finger protein 128, RING-type E3 ubiquitin transferase RNF128.
What are the subcellular locations of this protein?
Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity).
Protein: ILVC_TROW8
Sequence: MSEIGTRVYTECDADLSLIQNVLVAVIGYGSQGHAQALNLRDSGVNVVIGLKENSASRKSAQDSGFEVLLPQEAAKKAQLIALLVPDPAQRDVYESAIKHNLSEGDALLFSHGFNIRYGYITPPDGVDVLMVAPKGPGHMVRREYLDNRGTPAVFAIEKDASGRCFDLALSYAKGIGALRAGAIQTTFTEETETDLFGEQAVLCGGLEQLIQYGYETLVEAGYQPEVAYFEVLHELKLIIDLIVEGGLSKSRWSISDTAEYGSYVSGPRVIDKHVKENMKKILGEIRSGEFANRFIKDQDSGANEFTQLREIAARHPIEEVGARLRALFSWSK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: LEU3_CHRSD
Sequence: MSRKILVLPGDGIGPEITREAVKILNACREAGLEASIEEGLVGGAGIDAHGVPLPDETLASAKAADAVLLGAVGGPQWDKIEDLSKRPEKGLLGLRKNLNLFGNLRPALLYPQLASASSLKPEIVAGLDIMIVRELTGGIYFGQPRGIEERDGERVGYNTYIYAEHEIERIGRVAFEMARERGGKLCSVDKANVLEATILWREVMERLAPEYPDVALSHMYVDNAAMQLVRAPKQFDVIVTGNMFGDILSDAAAMLTGSIGMLPSASLNEQRQGMYEPCHGSAPDIAGQGIANPLATILSVAMMLRYSLEAPQLAERIERAVGTVLDQGLRTADIAFEGTAPVSTQAMGDAVLAAFQAQ
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: V10_SPTNK
Sequence: MPKYTDDDIFDDGAPQVAKGFDRGIDYLDIAAKLKKGLKKNYKVLQDTESTANAKRFAGSRVIYIIIALLQLKNCSRISEAIVATKKFSVSKNLNERVVVKIAKSEKDLIDRKTKDKIHTKPRYRDMVFPVDLVDTKIFKYIVKTKYWTKFCEFDSPRKRVLDFLLGHYECNTHSLRYAGINYLLNVEKRDMNVVAKFVGHANVNQLVLYTQTKALDEIFDRKIVV
What is the function of this protein?
May catalyze site-specific integration of viral genome into host or helper virus DNA.
What are the official names of this protein?
Putative integrase V10.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: PSAJ_PAUCH
Sequence: MKKFLTTAPVFSAIWFTLTAGIMIEFNRFYPDLLFHPL
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, organellar chromatophore thylakoid membrane; Single-pass membrane protein.
Protein: QKIL1_ARATH
Sequence: MMMMTSLGGGAGGGGGGGGSGGGRFVTYPPPLSVPPSAPQSPNFSGGLRSQPSFLVEQEKYLSELLAERHKLTPFLPVLPHVCRLMNQEILRVTTLLENALSQSRFDHPSPLASGGIFQNSRADMNGWASQFPSERSVSSSPAPNWLNSPGSSSGLIVKRTIRVDIPVDKYPNYNFVGRLLGPRGNSLKRVEASTDCRVLIRGRGSIKDPIKEDMMRGKPGYEHLNEPLHILVEAELPIEIVDARLMQAREILDDLLTPVEETHDFYKKQQLRELALLNGSLREEGSPMSGSISPYNSLGMKRAKTRG
What are the official names of this protein?
KH domain-containing protein At4g26480, Quaking-like protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPE_XANC5
Sequence: MSDVLELTCDLIARASVTPADAGCQAAIAQRLRAAGFGCEHLRLGEVENLWATHGSGAPVLVLLGHTDVVPPGPREAWTSDPFDPQIRDGVLYGRGAADMKGSVAAFVVAAEQFVAAHPTHSGTLAVLLTSDEEGDAIDGVRRVAEVFRERGQTIDWCITGEPSSTERLGDLLRVGRRGSLSGTLTVKGVQGHVAYPHKARNPIHLAAPALAELVARQWDDGFESFPPTSLQLSNIHAGTGANNVIPGELQVAFNLRYTPHWDAPRLEAEITALLDRHALDYTLRWHRSGEPFYTPEGRLRSVAREVLGEFAGAPPEESTGGGTSDARFIAPLGAQCIEVGPVNASIHQVDEHVRVADLQALPALYRTLIERLLVE
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: YGEF_ECOLI
Sequence: MKPRNINNSLPLQPLVPDQENKNKKNEEKSVNPVKITMGSGLNYIEQESLGGKYLTHDLSIKIADISEEIIQQAILSAMSIYKFSITDDLMSMAVNELIKLTKIENNVDLNKFTTICTDVLSPRVTRHNKEKNKRHSTLLKNPLFNFH
What are the official names of this protein?
Putative uncharacterized protein YgeF.
Protein: PSBJ_BETVU
Sequence: MADTTGRIPLWIIGTVAGILVIGLIGIFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: BM86_RHIMP
Sequence: MRGIALFVAAVSLIVEGTAESSICSDFGNEFCRNAECEVVPGAEDDFVCKCPRDNMYFNAAEKQCEYKDTCKTRECSYGRCVESNPSKASCVCEASDDLTLQCKIKNDYATDCRNRGGTAKLRTDGFIGATCDCGEWGAMNMTTRNCVPTTCLRPDLTCKDLCEKNLLQRDSRCCQGWNTANCSAAPPADSYCSPGSPKGPDGQCINACKTKEAGFVCKHGCRSTGKAYECTCPSGSTVAEDGITCKSISHTVSCTAEQKQTCRPTEDCRVHKGTVLCECPWNQHLVGDTCISDCVDKKCHEEFMDCGVYMNRQSCYCPWKSRKPGPNVNINECLLNEYYYTVSFTPNISFDSDHCKWYEDRVLEAIRTSIGKEVFKVEILNCTQDIKARLIAEKPLSKHVLRKLQACEHPIGEWCMMYPKLLIKKNSATEIEEENLCDSLLKDQEAAYKGQNKCVKVDNLFWFQCADGYTTTYEMTRGRLRRSVCKAGVSCNENEQSECADKGQIFVYENGKANCQCPPDTKPGEIGCIERTTCNPKEIQECQDKKLECVYKNHKAECECPDDHECYREPAKDSCSEEDNGKCQSSGQRCVIENGKAVCKEKSEATTAATTTTKAKDKDPDPGKSSAAAVSATGLLLLLAATSVTAASL
What are the official names of this protein?
Glycoprotein antigen BM86, Protective antigen.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: CYB_SORPE
Sequence: MTNLRKTHPLMKIINSSFIDLPAPSNISSWWNFGSLLGVCLIVQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGLYYGSYMFLETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSDLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAGVHLLFLHETGSNNPSGLCSDADKIPFHPYYTIKDILGVLLLILVLTSLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLAVIPFLHTSKQRSMMFRPFSQCLFWILVADLLTLTWIGGQPVEHPFIIIGQLASILYFLLILVLMPITSLLENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TATB_HAEI8
Sequence: MFDIGFSELILLMVLGLVVLGPKRLPIAIRTVMDWVKTIRGLAANVQNELKQELKLQELQDSIKKAESLNLQALSPELSKTVEELKAQADKMKAELEDKAAQAGTTVEDQIKEIKNAAENAEKPQNAISVEEAAETLSEAEKTPTDLTALETHEKVELNTHLSSYYPPDDIEIAPASKSQSSKTKS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PURQ_LISMO
Sequence: MKFAVIQFPGSNCDLDMLHAIRDSLGEEAEYIWHAETSLAGFDAVLLPGGFSYGDYLRTGAIAKFSSIMPEVLRFAEMGKPVLGVCNGFQILTEIGLLPGALIRNNNLHFICKTVPLRVANASTMFTELYEEGEIIQVPVAHGEGNYYCDDETLLKLKENNQIVFTYDSVNPNGSRADIAGIVNERGNVLGMMPHPERAVEEIIGGTDGLRLFESVVKAWKEEQVNA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: R9BP_MOUSE
Sequence: MAREECKALLDALNKTTACYHHLVLTVGGSADTQDLREELQKTRQKARELAVATGARLTVALRDRSLATEERAEFERLWVAFSGCLDLLEADMQRALALGATFPLHAPRRPLVRTGVTGGSSAVAARALSARSLRHEAESDFDVADLPQLEREVLQVGEMIDDMEMKVNVPRWTVQARQAAGAELLSGASAGASSAGGISVEERAGPCDPSKALAATVFSAVLLVAVALALCVAKLS
What is the function of this protein?
Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction.  Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform.  Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place.  Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale.  It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation.
What are the official names of this protein?
Regulator of G-protein signaling 9-binding protein, RGS9-anchoring protein.
What is the protein family that this protein belongs to?
Belongs to the RGS7BP/RGS9BP family.
What are the subcellular locations of this protein?
Membrane; Single- pass type IV membrane protein.
Protein: SIK1_MOUSE
Sequence: MVIMSEFSAVPSGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQADPTLLQQDDPAFDMQGYTSNLGDYNEQVLGIMQALGIDRQRTIESLQNSSYNHFAAIYYLLLERLKEHRSAQPSSRPTPAPTRQPQLRSSDLSSLEVPQEILPCDPFRPSLLCPQPQALAQSVLQAEIDCDLHSSLQPLLFPLDTNCSGVFRHRSISPSSLLDTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLAEVSTHFSPLNPPCIIVSSSATASPSEGTSSDSCLPFSASEGPAGLGSGLATPGLLGTSSPVRLASPFLGSQSATPVLQTQAGLGTAVLPPVSFQEGRRASDTSLTQGLKAFRQQLRKNARTKGFLGLNKIKGLARQVCQSSVRTPRGGMSTFHTPAPSSGLQGCTTSNREGRSLLEEVLHQQRLLQLQHHSSTAAASSGCQQGPQLSPVPYVLAPCDSLLVSGIPLLPTPLLQAGMSPVASAAHLLDTHLHISAGPVALPTGPLPQCLTRLSPGCDPAGLPQGDCEMEDLTSGQRGTFVLVQ
What is the function of this protein?
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression.  Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2.  Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis.  Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1.  Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes.  Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2.  Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity.  Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1.  In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1.
What are the official names of this protein?
Serine/threonine-protein kinase SIK1, HRT-20, Myocardial SNF1-like kinase, Salt-inducible kinase 1, SIK-1, Serine/threonine-protein kinase SNF1-like kinase 1, Serine/threonine-protein kinase SNF1LK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ.
Protein: UBID_BLOPB
Sequence: MKYKDLRDFIKILEHRGDLKRIKFPINPDLEITEIADRTIKSGGPALFFENPTGYTIPVLCNLFGTPNRIALGMGKESILSLRDVGKLLAFLREPELPTGVHDFFSKIPHFRHILHMPIKRVSTAPCQENVWCNQDVDITHMPIMRCWPQDVSPVITWGITITRGLKSKRQNLGIYRQQVLSKNKIIMRWLSHRGGALDFQEWHKNTSERRFPITVALGADPATLIGAVVPIPDTLSEYAFSGLLRGCRTEVIKCISCDLDVPANSEIVLEGYLERDETAIEGPFGDHTGYYNTTAKFPVCTITHITQRNNPIYLSTYTGRPPDEPAILGMAMNEMFIPIIQKQFPEITDFYLPPEGCSYRLAIVTIKKQYIGHAKRIIFGIWSFLKQFMYTKFIIVCDDDINARDWNDVVWAITTRMEPDRDTIIVKNTPIDYLDFSSPISGLGSKIGMDATNKWPGETEREWGIPIKMHDTVRHYIDSIWDKLDI
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.