PharMolix/UniProtQA huggingface dataset:
Protein: ARHGA_HUMAN
Sequence: MRPPGFLSRAPSLNRAERGIWSCSMDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEAPAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLHVPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEAETPEVTEDRQPNSLSSEEPPTSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVTSLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSSGSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHRKARQPHQEELAPTVMVWQIPLLNI
What is the function of this protein?
May play a role in developmental myelination of peripheral nerves.
What are the official names of this protein?
Rho guanine nucleotide exchange factor 10.
Protein: RUVB_POLSJ
Sequence: MSIQTDDFSAADLPPVKRVMSAAPASPHEEAIERALRPKLFDEYVGQAKVREQLEIFIGAAKKRSEALDHVLLFGPPGLGKTTLSHIIAHELGVNLRQTSGPVLEKPKDLAALLTNLEKNDVLFIDEIHRLSPVVEEILYPALEDYQIDIMIGEGPAARSIKLDLQPFTLVGATTRAGMLTNPLRDRFGIVARLEFYTAEELGRIVRRSASLLNAPMDEEGGFEIARRSRGTPRIANRLLRRVRDYADVKGTGQITLDIANKALAMLDVDPQGFDVMDRKLLEAVIHRFDGGPVGLDNIAASIGEERDTIEDVIEPYLIQQGYLQRTPRGRIATLAAYRHLGVAPPVSGNDMFT
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RBFA_SALHS
Sequence: MAKEFGRPQRVAQEMQKEIAIILQREIKDPRLGMMTTVSGVEMSRDLAYAKVFVTFLNDQDEAAVKNGIKALQEASGFIRSLLGKAMRLRIVPELTFFYDNSLVEGMRMSNLVTNVVKHDEERRVNPDDSKED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA2D1_MOUSE
Sequence: MAAGCLLALTLTLFQSGLIGPSSEEPFPSPVTIKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDPERNESEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNVQNPKSQEPVTLDFLDAELENEIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPREYCNDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRILLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSIADILQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTRLLMQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWSIFGLQFILLWLVSGSRHYLL
What is the function of this protein?
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (By similarity).  Plays an important role in excitation-contraction coupling (By similarity).
What are the official names of this protein?
Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1.
What is the protein family that this protein belongs to?
Belongs to the calcium channel subunit alpha-2/delta family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: BKRB1_TUPMI
Sequence: MAAQTLLELQPSNQSQLSALNTTSCDNAREAWDLLYQVLPIFILTICAFGLLGNLFVLSVFLLLRRRLTVAEIYLVNLAASDLVFVLGLPFWAQNIWNQFNWPFGDLLCRVVNGVIKANLFISIFLMVAISQDRYCVLVHPMASRRRRRRRRARATCMVIWAVGALLSTPTFLLRSVSAVQDLNISACILLLPHQAWHVARIVELNVLGFLLPLAAIIFFNGHILASLRGQGEVSQTRIGGPKDCKTTVLILTLVAAFLVCWAPYHCFAFLEFLFQVRAVRGCFWEDFIDLGLQLANFFAFTNSCLNPVIYVFVGRLFRTKVWELYQQCTPRRPAPLSSSRRKEILRRFWRN
What is the function of this protein?
This is a receptor for bradykinin.  Could be a factor in chronic pain and inflammation.
What are the official names of this protein?
B1 bradykinin receptor, B1R, BK-1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NAGZ_YERPY
Sequence: MGPVMLDVASYELDAEEREILKHPLVGGLILFSRNFHDAEQLRELVRQIRAASHERLVVAVDQEGGRVQRFRDGFTRLPAAQSFAAINDAATAAQLAQEAGWLMAAEMMAMDIDISFAPVLDIGHVSAAIGERSFHSDPQQARIMAECFIRGMHSAGMKTTGKHFPGHGAVTADSHKETPHDNRPLAEIRTHDMVIFRELIQRKLLDAIMPAHVIYTEADARPASGSAYWLQEILRQELGFEGIIFSDDLSMEGAAIMGSYAERGQASLDAGCDMILVCNNRQGAVSVLDNLSPIKADQLTRLYHSGQFDRQTLMASSRWQQANKALTALSERWDAHKQTLGQ
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_STRSY
Sequence: MTVTMQYEKDVTVAALDGKRIAVIGYGSQGHAHAQNLRDTGHDVIIGVRAGKSFDKAKEDGFETFEVAEAAKQADVIMILAPDEIQADLYNEEIAPNLEAGNALGFAHGFNVHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKHIAMDWAKGVGSARVGLLETTFKEETEEDLFGEQAVLCGGLTALMQAGFEVLTEAGYAPELAYFEVLHEMKLIVDLVYEGGFKKMRQSISNTAEFGDYVSGPRVITDQVKENMKAVLADIQSGKFANDFVNDYKAGRPRMEAYRKEAENLEIEKVGAELRKAMPFVGRNDDDAFKIYN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SMC_CHLTE
Sequence: MYLSKIELFGFKSFAHRVRIHFDKGLTAIVGPNGCGKTNVVDAIRWVLGEQKSMLLRSPKMENIIFNGTKRLKPLSFTEVSITIENTRNILPTEYTEVTVTRRLYRNGDSDYLLNMVPCRLKDILDLFADTGMGSDAYSVIELKMIEEIISNKSEERLKLFEEAAGITRYKQRRKQTFRQLESASRDLARVDDVLAEVEKKVRNLRLQVRKAERLKEIREELRTLDLTLSAISMDEHLQKLRPLLDSIAAEERQCHELAATIAKLDSAHQESELRQLELERKLADAQKELNASNQLVHTLEKQLLQHKEKQKNLLQTIERLNYSIADKGRKRLEQEALSKELSEKQTPLQEVCTAQLAEFERLKKQEVELNSALDASRQALQSERRAVAELQKSLNALNLTRQSLRTRKEHLEGSVNRLDQRKRDLERSMEQAEPERRRTSEAIEEKKIALDELKKEEERLVALKASITEQSEKKKEELLSLKSEHNHLNNRIALCNSILEKFEGLPEGVAFLEKQRAGKPGLGCLSDLISVRENDKKAINAALGESLGYYLCRNLEEARLAVSSLAKADKGKVHFLILDLIDGGAKIDYAEIEGARRAIDLVETPAELSKALNLLLQHCYVVADLDAAEQLGKKHPEALFITEKGEKFTRRGMLYGGSAKGGESVRLGKKAERDRLQKQMAGMAETIAEAENALAVLRKEFSAIDTERVKRAAASISQEISALEKRLARLEAEERSGADQIAHADRERTALIASMQSVLDELEKTQPETLRIEAEIETAQQKVNVMQEELSAGESRSRALHAELQAQQGRYRDAQLDLEKHRFRASACQQTIVTLSDEIEGMQHQIARAEKEVAELGQSIAQATAEHEQAVVVSARQQEALNELESSYRDLQTKNHDTLSNLRDLRRKHDLSQQMLAEFNNRKAKLEQEIAHLQATVMERYGVELEMMPAHVPEGFDVAASRERLAYLQKQKEQFGGVNELALEEYESEKERLDFLTAQKEDLVSAEKQLRETIEEINRTALEKFRETFNQVRKNFIRIFHDLFDPEDEVDLLITTSDEDPLEAHIQIVAKPRGKKPLAIEQLSGGEKALTALSLLFAIYLVKPSPFCILDEVDAPLDDANVGRFIKLLKKFENNTQFIIVTHNKKSMASCQALYGVTMEEEGVSKLIPVKIENARSEETAS
What is the function of this protein?
Required for chromosome condensation and partitioning.
What are the official names of this protein?
Chromosome partition protein Smc.
What is the protein family that this protein belongs to?
Belongs to the SMC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALLTR_NEZVI
Sequence: GFKNVALSTARGF
What are the official names of this protein?
Allatotropin-related peptide, ATRP.
What are the subcellular locations of this protein?
Secreted.
Protein: FARP1_CHICK
Sequence: MGETEQRPTAGSRLGAQENAGISTLEHGQKPPLTPPGKLISIKIQMLDDTQETFEVPQRAPGKVLHDAVCNHLNLVEGDYFGLEFPDHKKMMVWLDLLKPVMKQIRRPKHVVVKFVVKFFPPDHAQLQEELTRYLFALQVKQDLAQGRLTCNDTSTALLISHIVQSEIGDFDETIDREHLAKNKYIPQQEALEDKIMEFHRKHTGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGHTKINAFNWAKVRKLSFKRKRFLIKLRPDVNSSFQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIRSIRSLTAQPSEQHAEVPKQSFQSSSFAYGDDSDAAAVQSCQQGKELKASTEDTGQHKSPSLKKSPKEGRKVDGAVVSAVEEEEEAATDRMQQNRPQSQQPSTAGSLTGSPHLSELSINSQGGPSVANMSLSPNLSPDAKQSSPLISPLLNDPSCIRTEEEEEVKKKRFPTEKAYFIAKEVATTERTYLKDLEVITSWFQSAVSKEDCMPETLKNLIFSNFEPLHKFHTGFLKEIEQRLALWEGRSNAHIKGGHQRIGDVMLKNIQGMKQLTIHLWKHNEILTELENGIKNSRKLETFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQIMERLCKHYPPNHVDFRDSRAALAEITEMMAQLHGNMIKMENFQKLHELKKDLIGIDNLVIPGREFIRLGSLSKLSGKGLQQRMFFLFNDILLYTSRGLTASNQFKVHGHLPLYGMTIEDSEEEWGVPHCLTLRGQQQSIIVAASTRAEIDKWIEDIQMAIDLAEKSSDPVPELLASSPPDNKSPDETTVDQESEDDLSASRTSLERQSPHRGNTTVHVCWHRNTSVSMIDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCMFFYKSHQDNHPLASLPLLGYSLTIPSESENIHKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSALRTRALSHREPHTY
What is the function of this protein?
Functions as guanine nucleotide exchange factor for RAC1 (By similarity).  Plays a role in semaphorin signaling via its interaction with PLXNA4.  Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses.
What are the official names of this protein?
FERM, ARHGEF and pleckstrin domain-containing protein 1, FERM, RhoGEF and pleckstrin domain-containing protein 1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine.
Protein: RL31_MYCBT
Sequence: MKSDIHPAYEETTVVCGCGNTFQTRSTKPGGRIVVEVCSQCHPFYTGKQKILDSGGRVARFEKRYGKRKVGADKAVSTGK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: NEUL_MOUSE
Sequence: MITLCLSALRGLHRAGGSRIRLRMTLGREAASPLQAMSSYTAAGRNVLRWDLSPEQIRTRTEELIAQTKQVYDTVGTINLEDVTYENCLQVLADIEVKYIVERTMLDFPQHVSSDREVRAASTEADKRLSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLPEHVKNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDEDKYKVTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKEENTIILQQLLPLRAQVAKLLGYNTHADFVLELNTAKSTSHVATFLDDLSQKLKPLGEAEREFILSLKKKECEERGFAYDGKINAWDLHYYMTQTEELKYSVDQESLKEYFPIEVVTEGLLSIYQELLGLSFEQVADAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMSVAALVVNFSQPIAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDIDSLRKLSKHYRDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNASLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFRKEGIMNPEVGMKYRNLILKPGGSLDGMDMLQNFLQREPNQKAFLMSRGLNAS
What is the function of this protein?
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.  Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.
What are the official names of this protein?
Neurolysin, mitochondrial, Microsomal endopeptidase, MEP, Mitochondrial oligopeptidase M, Neurotensin endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Cytoplasm, cytosol.
Protein: RL10_TOLAT
Sequence: MALGLEDKKAIVAEVSEAAKGALSAVAADSRGVTVAKMTALRQSAREAGVYMRVVRNTLLTRAVEGSDFECMKDVFVGPTLIAFSNEHPGAAARLFKEFAKGNDKFSIKGGAFQGEFIPAAQIDRLATLPTYEEAIAKLMATMKEASAGKLVRTLAALRDKKEAEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ANGI_AOTTR
Sequence: MVMGLHLLLLVFILGLGLTPPTLAQNDIRYIKFLDQHYDPKTKNGNDKYCEKMMRLRNMISPCKEINTFIHGNKASIKAICGNQNGEPHNGNQRISKSAFQVTICRHIGGSPRPPCRYRATAGFRNLVVACENDLPVHLDESIFRP
What is the function of this protein?
Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs).  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus.  Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA.  Angiogenin induces vascularization of normal and malignant tissues.  Angiogenic activity is regulated by interaction with RNH1 in vivo.
What are the official names of this protein?
Angiogenin, Ribonuclease 5, RNase 5.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: SPED_AZOVD
Sequence: MKSKLKLHGFNNLTKTLSFNIYDICYAETPEDQQAYVRYIDEEYDAQRLTQILTDVVDIIGANVLNIARQDYDPQGASVTILISEQPVEPTESQIEESPGPLPETILAHLDKSHITVHTYPEIHPVDGLATFRVDIDVSTCGVISPLKALNYLIHQFDSDIVTVDYRVRGFTRDVEGRKHFIDHEINSIQKYLSADTRAAYQMTDVNVYQENMFHTKMLLKDFDLDNYLFGDATLNLSVEQRKQVEKRLRHEMLEIFYARNMPH
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: EX7L_VIBVU
Sequence: MSSLTNPNIFTVSRLNSEVRLLLENQLGIVWLVGEISNFSAPVSGHWYFTLKDSMAQVKCAMFRGNNRLVSFKPTNGNQVLVKARLSLYEPRGDYQLIIESMQPEGDGRLQQQFDALKMKLASEGLFAQSSKQAIPEHPKCVGIITSKTGAALYDILDVLKRRDPSLPVVIYPTLVQGEEAAIQIAQAIGRANSRNECDVLIVGRGGGSLEDLWCFNNEIVARTIAASQIPIISAVGHEIDVTIADFVADLRAPTPSAAAELVSRDNSHKDQALMSREQKLRAAWRHYLTEQNRTIVSLSHRLEKQHPRYRLMRQTQQADELQIRLQRAMEKYLAQREQKVSRVQHKLQLLSPVRQISEQKNALARVEQKMMDAMDRKLLRLRHQIAIAAEKLDTVSPLATLKRGYSITQSESGDVITRQSQIKTGDTLVTRLSDGEIRSTVN
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_MYCLB
Sequence: MLIPRKVKHRKQHHPRQRGIASGGTKVNFGDYGIQALEHAYVTNRQIESARIAINRHIKRGGKVWINIFPDRPLTKKPAETRMGSGKGSPEWWVVNVKPGRVLFELSYPNEQTARAALTRAIHKLPIKARIVTREEQF
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: SAT_POPEU
Sequence: KADAVFAFQLR
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: PAPS_PHOAM
Sequence: MEYRYSYVIDPSSYDNQGLCNGIPLRVHRNADIEEYATISLRNDWRKHVGPLPLTSYGGNLGPKYNFTAVTLPECRPDRLEIVSYIMEFAFLHDDLVDTAQVDEALALNDTWRDGITEGLDTTSAKGKKSGEGLILRNILKEVTAIDPVRAAELMKFWKRDLDVSRDRKHFRDFDDYMEYRIVDCASYFLIALSTFAMALTIPAEDKDEVFTLLTRPVWAAAALTNDVQSWEKEDKLFQKDNATDMTNGVWMLMKQYSIGVEEAKRRILGKAREHVAEFVKTLSQIHNRLDLSLDSRLFVEAMQYMISGNLMWGISTPRYHSDQSLDEMMVARMKYGWPNHREVTKLTSDLENRGTKRTHQDDTEGVQSVKRFNGASTKNGINGTNGINGLNGINGSNGVKIKRHKNKEYSGALTKDSDLVLNMDLNGLSSAIICAPADYIGSLPSKGIRDNVADALSIWLDVPAKELNQIKRAINLLHNASLMLDDVQDGSVLRRAQPTTHTVFGPAQTINSAGHQIIQAMNEIRKLGSDDCLDIFSEELEKLYVGQSHDLYWVYNDSCSPTIEDYFKMVDYKTGGLFNMLARLMTAKSSSSSSPDLTALVGLLGRYFQIRDDYMNLTSADYTVEKGFCEDLDEGKFSITLLHALSAAPEPEALLLRNLMSGRRNDGKLSVVQKNLALSIIEGARSLEYTAAVLQKLYKAIVRELESTERQFGENKPFRFLLSLLKV
What is the function of this protein?
Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of the diterpene methyl phomopsenonate (PubMed:19161275, PubMed:28270685).  At first, the universal precursor of diterpene, geranylgeranyl diphosphate (GGPP) is provided and is cyclized by the unusual bifunctional terpene synthase PaPS to give phomopsene (PubMed:19161275, PubMed:28270685).  The C-terminal prenyltransferase domain of PaPS catalyzes formation of GGPP, whereas the N-terminal terpene cyclase domain catalyzes the cyclization of GGPP to phomopsene (PubMed:19161275, PubMed:28270685).  Since the oxidation of a methylgroup to a carboxyl group is frequently catalyzed by a cytochrome P450 monooxygenase, the C-16 methyl group would be oxidized by the cluster-specific cytochrome P450 monooxygenase ORF3 (Probable).  Subsequently, oxidation of the allylic position and methylation of the carboxyl group may give methyl phomopsenonate (Probable).  Although further study is necessary to identify genes such as a monooxygenase and a methyltransferase, the predicted functions of genes on the cluster are correlated with the structure of methyl phomopsenonate (Probable).
What are the official names of this protein?
Phomopsene synthase, PS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the FPP/GGPP synthase family.
Protein: COBQ_BRUC2
Sequence: MARAIMFQGTGSDVGKSVLVAGLCRVARNRGLKVRPFKPQNMSNNAAVSDDGGEIGRAQWLQALACGVPSSVHMNPVLLKPQTDMGSQLIVQGQVRGEARGRYYQELKPQLMAAVMESFAKVGDGADLVLVEGAGSPAEINLRAGDIANMGFATHADVPVVLVGDIDRGGVIASLVGTHTILPQEDRAMVRGFLINKFRGDISLFDDGLAAITRFTGWRSFGVVPWLKAVSRLPAEDSVILERAVRGDKKALIVAVPMLPRIANFDDLDPLKAEPAVEVVMVPPGSSLPADAGLVVLPGTKSTIADLLALRENGWDRELVAHVKRGGHVLGICGGFQMLGRRISDPAGIEGNVRDIEGLGLLDIETMMEPEKVVRNVEAVSLLHDEPLEGYEIHIGRTSGPDMARPFARIGDHDDGAVSPDGRIMGTYLHGVFSADRFRHHFLRALGVEGGQMNYRESVEEALDELAEGLEASLDIDGLFALA
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: RL3_SODGM
Sequence: MKGLIGRKVGMTRIFTEDGVSIPVTVIEIEANRVTQVKDLENDGYRAIQVTAGTKKANRVIKPEAGHFAKAGVEAGRGLWEFRVEDGEEVTVGQSITVELFADVKKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGKVFKGKKMAGQLGNERVTVQSLDVVRVDVERNLLLVKGAVPGATGGDLIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RAB7_GOSHI
Sequence: MASRRRMLLKVIILGDSGVGKTSLMNQYVNRKFSNQYKATIGADFLTKEVQFDDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVHDVNVMKSFDNLNNWREEFLIQASPSDPENFPFVVLGNKVDVDGGNSRVVSEKKAKAWCASKGNIPYFETSAKEGFNVDAAFECIARNALKNEPEEEIYLPETIDVASGGRPQRSTGCEC
What is the function of this protein?
Protein transport.  Probably involved in vesicular traffic (By similarity).
What are the official names of this protein?
Ras-related protein Rab7.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: IHFA_HAHCH
Sequence: MGALTKADMAERLYQEVGLNKREAKEMVEAFFDEVRDALSHNEQVKLSGFGNFDLRDKKQRPGRNPKTGEEIPITARRVVTFRPGQKLKAKVEAYAGTQS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: NTPPA_PSEPK
Sequence: MTPLYLASGSPRRRELLTQIGVPFIVISAPVDESPLPSESAPAYVERLARAKAAAGLVSVDGPAVVLGADTAVVLDGRILGKPENREDALAMLADLSGREHQVLTAVALDDGQRVHSFCVTSTVRFRAISTDEAQRYWASGEPSDKAGGYAIQGLGAVFVSGLSGSYSAVVGLPLCETADLLGQFGIACWQSLAHTPEVTNPQ
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.