PharMolix/UniProtQA huggingface dataset:
Protein: RP13A_SCHPO
Sequence: MSLITFKAGKLRRVPGTKLLRADPEKGYIVMNRDAYGLIHFQWAKRNDLENPEDDIIVFSSECTFEKVTECTTGRAYMLKYPSSAHSLFYWMQEASDDNDTSYAERINSYIKDQDLLDPARSDVATVSDMMEVDTVEQSEPIAQPTESSKESSEIGAPNSDEINSSEAVRNLLATISAQAGFGGSTVDLCEILKPSNLTDLLCQEGVIDRLMPYMPPDTPNNLEGVLAIVSSPQYAQALRSFSQALNSPGGVNIISALGLSLDESANPNEGGALQFLKAIARFVSRNNGSE
What is the function of this protein?
Ccomponent of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:21098295).  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.  Within the complex, functions as a proteasomal ubiquitin receptor (Probable).
What are the official names of this protein?
Proteasomal ubiquitin receptor ADRM1 homolog rpn1301, Regulatory particle non-ATPase 13a protein.
What is the protein family that this protein belongs to?
Belongs to the ADRM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CBR1_MACFA
Sequence: MKSGIRVALVTGSNKGIGLAIVRDLCRLFSGEVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRTLRDFLLKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNISSMMSLRALKSCSPELQQKFRSETITEEELVGLMNKFAEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPSATKSPEEGAETPVYLALLPLDAEGPHGQFVMEKRVEQW
What is the function of this protein?
NADPH-dependent reductase with broad substrate specificity.  Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics.  Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity).  Can convert prostaglandin E to prostaglandin F2-alpha (By similarity).  Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates.  Catalyzes the reduction of S-nitrosoglutathione.  In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity).
What are the official names of this protein?
Carbonyl reductase [NADPH] 1, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], 20-beta-hydroxysteroid dehydrogenase, Alcohol dehydrogenase [NAD(P)+] CBR1, Prostaglandin 9-ketoreductase, PG-9-KR, Prostaglandin-E(2) 9-reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_XANP2
Sequence: MSVVTSIRKSLVPIHREGYPFIAIAVVIALGLMVFSTFLGMIGVGLAIWTALFFRDPPRVTPVRDGLVVAPADGRISQVGLARPPRELDLSDEPLLRVSIFMNVFNVHVNRAPVTGRIERLAYKPGLFLNADLDKASEDNERNGLVISTPLCRVGVVQIAGLIARRIVSFVREGESIGVGERFGLIRFGSRVDVYLPVGTRVLVSEGQLTVAGETVLCDLSAQQPRETAYRVS
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PRZ1_SCHPO
Sequence: MERQRSEEANRRFKDLNPSSLYDNLSKPDLGGSSELHTYMNDTSLADIPLFEDTLASEVSSSLISNPSKNNIQHLHPNTSEPFKTSSKSDEYDSYPRTGNVPTFSFTELNDTSVSGFGSQAVFENSVSPLSNPSNSPQAFDLTQGSSSTHNANDFTVNNVGSRRQSIYEFNIGIPSSNIDSSQFLPVSRAIAASEISPSSSPQLLTSFLPSGSVSNPSSPYLQGSVGALYEADAFNFVDVMSQASGTEVDSERFPSVDFEDPSLLMENQQNITGTGSFADYLQPPSSGSLGAFTNASPGESNTGIDFDTDNTNLNPSVDLLSNHSTPSFIFENSPSAEFSHQSSPYLVPNSGRTLNSENARESTIRSVNSPFSEDHADASLTTHVFDPISPTALSNSVLNYDSNNFSGTPQINVVPSSPSKSQSGPSLPANPLLQTDISITYSQSASPVSGQPAMNENSYDLQNANLCAPEMSPTYTARHRSNSAGSRFDAYEPIPQLYTHFSHSSECLSVNQDTELLGKIENDNSKSNDYLSVRNTRPRSRSLNSLVGNKSENSSSSKAKSESKSQGNYVCTFAGCNKRFTRAYNLKSHMNTHTNYRPFQCSICKKSFARQHDKRRHEQLHTGIKAFACVTCNQRFARMDALNRHYKSEVGQNCLRTATERGIQVPPSRKTAVASTSKQK
What is the function of this protein?
Involved in the regulation of calcium ion homeostasis.  Binds to the calcineurin-dependent response element.  Transcriptionally regulates pmc1.
What are the official names of this protein?
Transcriptional regulator prz1, Pbp1-responsive zinc finger protein 1.
What is the protein family that this protein belongs to?
Belongs to the EGR C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CPXT2_SYNJA
Sequence: MESTSSPELLQMARWLAGDFSNQEQAWENPPFFASIRVAYRPLPTAVLGGIGFYVEQAYSGHLEEPYRQAVVELTQVGDGIVIRNYRPLQPQRWRGCARGRAEQLSQLSAADLAYLPGCDVQVKRQGSLFVGVTEPGCRCCVVRNGQTTYLQTTLHLSENEFCSHDRGMDPVTHRQVWGAVAGPFRFRKVVDWQAELLQ
What is the function of this protein?
Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.
What are the official names of this protein?
Chromophore lyase CpcT/CpeT 2.
What is the protein family that this protein belongs to?
Belongs to the CpcT/CpeT biliprotein lyase family.
Protein: GATB_UREPA
Sequence: MQNFEVIIGIEVHTALNTKTKMFSNAATSHKSIPNTLINEIDLALPGTLPTVNQEVVHKGLFLANALHMRTNHQFIAFDRKHYYYLDLPKGYQITQNYFPIGQNGYIQIIDEYNNLKRIRIKQIHLEEDTAKQTNIGNQIYLDYNRAGWPLIEIVSEADLRSAQETVLFLEELRKILLFNDISDAKMEDGSLRVDVNVSIRPQGAKKFGTKVEIKNINSISNVAKAIDYEIRRQLNLILLNQNVEQQTRRFDDNTNTTVFMRSKNDAINYRYIREANIAPIHLSDDYVKKMFLTKSCSINDLRQQLAQKGLVSSAIEQLLSDGPLFKAFKYVDKIVNNPLSVYKWLCLEFIGLINKNTQNIEEITPELLQKIARMILLFDQTLINGKQTKIILEKIYLTNKDPQILIKELGFEQITNENEITKLWHQILAKNQEMLLQYNERPDRVEKFFMGEIMKLTKAQANPTISFNVLKKILQK
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: ATPE_SYNJB
Sequence: MTLMVRVITPDRTVWDAPSEEVILPATSGQLGILTGHAPLLTAIGNGVMRVKADGKWLAIAVMGGFAEVENNEVTVLVNRAERGEKVDKAAAQALLDEASKVLNTSSDKQERLQAKLDQQRARALIQAAEMGSKTGS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: BPIB4_RAT
Sequence: MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGDAISGTIQKSDAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIEANDNTAQLGGKYRYGEILDSDGSLRDLRHEDYRPSDSAYHRGPGRYRSAADPSSAGRLHRRELRPGEIPAGVATGALGPGGLLGTGGILANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAMLPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGALDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST
What is the function of this protein?
May have the capacity to recognize and bind specific classes of odorants.  May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites.  May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).
What are the official names of this protein?
BPI fold-containing family B member 4, Ligand-binding protein RY2G5, Long palate, lung and nasal epithelium carcinoma-associated protein 4.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm.
Protein: PSL1_SCHPO
Sequence: MSLAFTLLTSKDNTDEDEEHLELSSFNQEKLLEMISVFLSRLTRLNDSKQEATESDQIPLSPTSLKNPCLIFSAKNVPSISIQAYLTRILKYCPATNDVFLSVLIYLDRIVHHFHFTVFINSFNIHRFLIAGFTAASKFFSDVFYTNSRYAKVGGIPLHELNHLELSFFVFNDFNLFISLEDLQAYGDLLLSWYRQNGQNYNPTDVSCSIESPISHTPQQNQQDEQPRRPIMDRRLLSSHSIG
What is the function of this protein?
Cyclin partner of the cyclin-dependent kinase (CDK) pef1 (PHO85 homolog).
What are the official names of this protein?
PHO85 cyclin-like protein psl1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. PHO80 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at the barrier septum.
Protein: DAPD_METS4
Sequence: MSHADLARTIEAAWEDRADVTAATQGPVREAVEAALALLDSGQVRVAEKSGNADWQVNQWLKKAVLLSFRLTDMELISGAPGGAAWWDKVPSKFDGWDAERFRQAGFRAVPGAIVRRSAFIAPGAVLMPSFVNLGAHVGEGTMVDTWATVGSCAQIGKNCHISGGAGIGGVLEPLQANPVIIEDNCFIGARAEVAEGVIVGEGSVLSMGVYLGASTKIVDRATGEVVYGRVPPYSVVVSGSLPGKALPDGAPGPALYCAVIVKRVDAGTRAKTGINELLRD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS211_BRADU
Sequence: MQVLVRDNNVDQALRVLKKKMQREGVFREMKQRRSYEKPSERKTREKSEAIRRARKLARKQAIREGLLPAPPKKKLPERKPPLPQTAARPAG
What are the official names of this protein?
30S ribosomal protein S21 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: MUTS2_CLOB1
Sequence: MKDKSIKVLEFNKIQEILKNYTCTKAAKDIIEDLKPYDSMYEVREHLEETKEAFKLLITKGAPPFEGVYDIRSGISLAEKGSALLPGQLLKIAAVLRCARRFKEYINHKEEEESYRVLENICEGIFSLPKIEEEIFNAIEGEDEIADRASSTLYNIRRSLKEKNYSVRDKINSLVRSYSSYLQENIYTVRGDRYVLPVKAEHKGAVPGLVHDQSSTGATLFIEPMSLVNLNNEIKELMLKEKAEIERILTVLSAKINANITGVKTDANIVWELDFIFAKAKFASEYNCTCPTINDEGIVDIIEGRHPLIDRREVVPISVKLGEEFTSLMITGPNTGGKTVTLKTVGLIHLMAMSGLMIPARENSVISYFNNVFADIGDEQSIEQSLSTFSSHMKNIVEIMDKADENSLVLFDELGAGTDPTEGAALAISILENLRKRGTKIIATTHYSELKAYALRKEGVENASVEFDVETLRPTYRLLIGIPGKSNAFEISKRLGLPDYIIDFARENISNENIRFEELIQNLQEKSIKAQEDARLAENLKLERDKEKKKYEEKLEGLQKVRDNALIDARREAKNIIKEAKEEADKILKDIRQLERMGYSSDARRKLEEERKKLKDKLDSIEEKEIKTVHKGEALKNVKEGDEVLLASINQKVIVLSKPDNKGDVLVQAGIMKITANIKDLRAAKGSNSNNSSSKIKKSKKLNLNLRRVESSVDLRGMDAEEAIYTVDKYLDEAYLGGLGEVTIVHGKGTGVLRKTIMDMLKGHSHVKKYRLGEYGEGGTGVTVVELK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: PURA_PSEAB
Sequence: MGKNVVVLGTQWGDEGKGKIVDLLTEQAAAVVRYQGGHNAGHTLVIDGEKTVLHLIPSGILREGVQCLIGNGVVLAPDALLREITKLEEKGVPVRERLRISPSCPLILSYHVALDQAREKARGEAKIGTTGRGIGPAYEDKVARRGLRVGDLFHRERFAAKLGELLDYHNFVLQHYYKEPAIDFQKTLDEAMEYAELLKPMMADVAATLHDLRKHGKDIMFEGAQGSLLDIDHGTYPYVTSSNTTAGGTATGSGFGPLYLDYVLGITKAYTTRVGSGPFPTELFDDVGAYLAKRGHEFGATTGRARRCGWFDAVILRRAIEINSISGLCLTKLDVLDGLDVVRLCVGYKNADGDVLEAPTDADSYIGLQPVYEEMPGWSESTVGAKTLEELPANARAYIKRVEELVGAPIDIISTGPDRNETIILRHPFA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TA2R3_PONPY
Sequence: MGLTEGLFLILSGTQFALGILVNCFIGLVNGSSWFKTKRMSLSDFIITTLAFLRIILLCIILTDSFLIEFSPNAHDSGVIMQIIDVSWTFTNHLSIWLATCLGVLYCLKIASFSHPTFLWLKWRVSRVMVWMLLGVLLLSCGSTASLINEFKLYSVFRGIEATXNVTEHFRKKRSEYYLIHVLGTLWYLPPLIVSLAAYFLLIFSLGRHTRQMLQNGTSSRDPSTEAHKRAIRIILSSFFLFLLYFLAFLIASFGNFLPKTKMAKMIGEVMTMFYPAGHSFILILGNSKLKQTFVEMLRCESGHLKPGSKGPIFS
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 3, T2R3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PANC_PSEPW
Sequence: MNTVKTVRELRAAIARARGEGKRIGFVPTMGNLHSGHAALVTKAAQRADFVVASIFVNPLQFGANEDLDKYPRTLAADQERLLQAGCNLLFAPTVEEMYPDGMAVQTRVSVPNLSEGLCGASRPGHFEGVATVVSKLFNMVQPDLAVFGEKDYQQLAVIRAMVRDLNMPIQIIGEPTVRAEDGLALSSRNGYLTAEQRATAPVVYRTLQQIGDAISRGQRDFAALVADGQAQLAAAGLRPDYLQVRHALTLRPAMVDDRDLVILVAAYLGNTRLIDNLYVHLDEKTA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_SORC5
Sequence: MSVTSEVQGLRALNEVDPEIAELIRLEERREADTLRLIASENYVSRAVLEATGSVLTNKYSEGYPHKRYYEGQQQVDVVEELARTRVAKLFGADHVNVQPYSGSPANLAVYLAFAQANDTIMGLGLPAGGHLTHGWSVSITGKYFKSVPYGVRESDHRIDLDQVRDLARAHRPKLIWCGTTAYPRTLDFAAFRAIADEVGAILAADIAHIAGLVAAGVHPSPVGIADVVTSTTHKTFRGPRGAMILCKKEHAGAIDKAVFPGLQGGPHNHTTAAIAVAAKEASEEGFRAYARQIVVNAQALGRALESRGFRLITGGTDNHLLLIDMTPKGIAGKPYAQALDRAGIVANYNSIPFDPRKPFDPSGLRIGTPAVTSRGMGVAEMERLAAWMDEVAQNVNDEARIARIAAEVAELCRGFPAPGIRL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: D103A_HORSE
Sequence: MRIHFLLFALLFLFLMPVPGNGGIINMLQKSYCKIRKGRCALLGCLPKEEQIGSCSVSGRKCCRKKK
What is the function of this protein?
Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Beta-defensin 103A, Defensin, beta 103, Defensin, beta 103A.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL31B_BURVG
Sequence: MKPGIHPDYREVVFQDMSNGFKFITRSTIQTRETIDHEGKTYPLAKIEVSSESHSFYTGQQKIMDTAGRVEKFKNKFGARASGKVAK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: ENGB_ALIF1
Sequence: MSKTIHYQKTHFITSAPDIRHLPEDEGIEVAFAGRSNAGKSSALNRLTNQKSLAKTSKTPGRTQLINLFKVEENCHIVDLPGYGFAQVPLEMKKKWQKSLGEYLQKRQCLQGLVVLMDIRHPLKDIDQQLVFWAVDQNIPVQILLTKADKLKSGARKAQVLKVREAAVDFGGEVEVDAFSSLKGIGVDKLRAKLDEWFAPAFELDDEFIEDLDAE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: PANX3_RAT
Sequence: MSLAHTAAEYMLSDALLPDRRGSRLKGLRLELPLDKMVKFVTVGFPLLLMSLAFAQEFSSGSPISCFSPSNFSVRQAVFVDSSCWDSLAHYKQDEAGQYTVKSLWPHKALPYSLLALAVAMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPHVFWDELEKARKERYFEFPLLERYLACKQRSHWLVATYLLRNALLLLFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLHEETHVPELITCRLTSLSVFQIVSVSSVAIYTVLVPVIIYNLTRLCRWDKRLLSIYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTQHTYDEHP
What is the function of this protein?
Structural component of the gap junctions and the hemichannels.
What are the official names of this protein?
Pannexin-3.
What is the protein family that this protein belongs to?
Belongs to the pannexin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: STEA4_HUMAN
Sequence: MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH
What is the function of this protein?
Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane.  Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524).  Can also reduce Cu(2+) to Cu(1+) (By similarity).  Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).  Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574).  Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107).  Inhibits anchorage-independent cell proliferation (PubMed:19787193).
What are the official names of this protein?
Metalloreductase STEAP4, Six-transmembrane epithelial antigen of prostate 4, SixTransMembrane protein of prostate 2, Tumor necrosis factor, alpha-induced protein 9.
What is the protein family that this protein belongs to?
Belongs to the STEAP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: SYA_SHEDO
Sequence: MFETTAKLRSAFLAYFETQGHQVVDSSSLVPHNDPTLLFTNAGMNQFKDVFLGMDKRSYSRAVSSQRCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEEAIRFAWTFLTETLKLPTERLCVTIYETDDEAFELWNKKIGVAAENIIRIGDNKGAPYASDNFWQMGDTGPCGPCSEIFYDHGDHIWGGRPGTPEEDGDRFIEIWNIVFMQYNRQADGAMLPLPKPSVDTGMGIERIAAIMQGVHSNYEIDIFKQLIAKTAEIIGVSDLENKSLRVIADHIRSCAFLIADGVMPSNEGRGYVLRRIIRRAVRHGNKLGATDTFFYKLVPTLISVMGDAAKGLVETQVIVEKALKAEEEQFARTLERGLGLLDNALNELSGKVLDGDTAFKLYDTYGFPVDLTADVCRERDITVDEAGFEAAMAEQRSRAQAAGNFGADYNKQLIIDEETQFCGYKGLSGEANVVALYLDGQAVNEVTQGQDAVVVLNNTPFYAESGGQVGDKGVLSAQGINFSVTDTQKFGQATGHQGKVLEGSIKVGTKLAAEVNKDLRQRTELNHSVTHLLHAALRQVIGTHVTQKGSLVNPERLRFDFAHFEGVKAAELKQVEELVNAQIRCNHELNTAEMAIDEAKEKGAMALFGEKYDEKVRVVTMGDFSIELCGGTHVGRTGDIGLFKITSEAGIAAGVRRIEAVTGAAAMAYVAEQQAMLDEAAGLLKSDSASVVAKLKAQLDKTKQLEKELSQLKDKLAAAASADMAGDAQDINGVKVLVKKLEGVDPGSLRGLQDELKQKLKSAIILLGTAKDGKVNLIAGVSNDLTAKVKAGELVAMVAQQVGGKGGGRPDMAQAGGTQVENLDAALASASTWIAERLA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y142_RICAE
Sequence: MSEVVVKEQLEQYISKIERLEQEKADLSQEVKDIFQDASSHGFDVKAMKSILKLKKLDKDKLAEQDAMLELYRDTLGI
What are the official names of this protein?
UPF0335 protein RAF_ORF0142.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: CH601_AZOC5
Sequence: MAAKEVKFAGEAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASKTNDLAGDGTTTATVLAQAIVKEGAKAVAAGMNPMDLKRGIDLATAAAVKDIQARAKKVSSSAEVAQVGTISANGDSSIGEMIAGAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEDPFLLIFEKKLSGLQPILPVLEAVVQSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVTLAQLGRAKKVILEKEKTTIVDGVGEKAEIEARVAQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALNATRAAVEEGIVPGGGVALLRAKKAVEALSSENPDIAAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVLESEGNFGFNAQTEQYVDLVAEGVVDPAKVVRTALQDASSVASLLVTTEALIAELPKKDAGMPAMPGGGMGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF9_BOVIN
Sequence: MESGKMASPKSMPKDAQMMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKKATVDADDVRLAIQCRADQSFTSPPPRDFLLDIARQRNQTPLPLIKPYSGPRLPPDRYCLTAPNYRLKSLQKKASASAGRITVPRLSVGSVTSRPSTPTLGTPTPPAMSVSTKVGTPVSLTGQRFTVQMPTSQSPAVKASIPATSAVQNVLINPSLIGSKNILITTNMVSSQNTANEASNALKRKHDDDDDDDDDDDDYDNL
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.  TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC).  The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13.  TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex.  TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes.  Essential for cell viability.  May have a role in gene regulation associated with apoptosis.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 9.
What is the protein family that this protein belongs to?
Belongs to the TAF9 family.
What are the subcellular locations of this protein?
Nucleus.