PharMolix/UniProtQA huggingface dataset:
Protein: FADS2_HUMAN
Sequence: MGKGGNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSLKKSGKLWLDAYLHK
What is the function of this protein?
Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain.  Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:12713571).  Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity).  Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have potent antibacterial activity (PubMed:12713571).  It can also desaturate (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity).  In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity).
What are the official names of this protein?
Acyl-CoA 6-desaturase, Delta(6) fatty acid desaturase, D6D, Delta(6) desaturase, Delta-6 desaturase, Fatty acid desaturase 2.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
Protein: TPX_LISMF
Sequence: MTQVTFKHNPVTLVGTERKVGDKAPNFTVVNRDLEEVTLHDYDGKVRLISVVPSIDTSVCSTQTRKFNEEASNLDNTVVLTISVDLPFAQKKWCAAEGLPNAITLSDHRDLSFGEAYGVVMKELRLLARSVFVVNAAGEIVYTEVVPEGSDHPNYEAAIEAAKKA
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: TOLB_ECO27
Sequence: MKQALRVAFGFLILWASVLHAEVRIVIDSGVDSGRPIGVVPFQWAGPGAAPEDIGGIVAADLRNSGKFNPLDRARLPQQPGSAQEVQPAAWSALGIDAVVVGQVTPNPDGSYNVAYQLVDTGGAPGTVLAQNSYKVNKQWLRYAGHTASDEVFEKLTGIKGAFRTRIAYVVQTNGGQFPYELRVSDYDGYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNGAPAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDQAGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDLATGGVQVLSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPATDGQVKFPAWSPYL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.  TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TFE_PYRFU
Sequence: MGRDKKNTALLDIARDIGGDEAVEVVKALEKKGEATDEELAELTGVRVNTVRKILYALYDAKLATFRRVRDDETGWYYYYWRIDTKRLPEVIRTRKLQELEKLKQMLQEETSETYYHCGTPGHPKLTFDEAFEYGFQCPICGEILYEYDNSKIIEELKKRIEELEIELGLRSPPKEEKPKKATRRKKSRSGKKKK
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: F90AH_HUMAN
Sequence: MMARRDPKSWAKRLVRAQTLQKQRRAPVGPRAPPPDEEDPRLKCKNCGAFGHTARSTRCPMKCWKAALVPATLGKKEGKENLKPWKPRVEANPGPLNKDKGEKEERPRQQDPQRKALLHMFSGKPPEKPLPNGKGSTESSDHLRVASGPMPVHTTSKRPRVDPVLADRSAAEMSGRGSVLASLSPLRKASLSSSSSLGPKERQTGAAADIPQPAVRHQGREPLLVVKPTHSRPEGGCREVPQAASKTHGLLQAARPQAQDKRPAVTSQPCPPAATHSLGLGSNLSFGPGAKRPAQAPIQACLNFPKKPRLGPFQIPESAIQGGELGAPENLQPPPAATELGPSTSPQMGRRTPAQVPSVDRQPPHSTPCLPTAQACTMSHHSAASHDGAQPLRVLFRRLENGRWSSSLLAAPSFHSPEKPGAFLAQSPHVSEKSEAPCVRVPPSVLYEDLQVSSSSEDSDSDLE
What are the official names of this protein?
Protein FAM90A17.
What is the protein family that this protein belongs to?
Belongs to the FAM90 family.
Protein: Y3412_MYCTO
Sequence: MRDHLPPGLPPDPFADDPCDPSAALEAVEPGQPLDQQERMAVEADLADLAVYEALLAHKGIRGLVVCCDECQQDHYHDWDMLRSNLLQLLIDGTVRPHEPAYDPEPDSYVTWDYCRGYADASLNEAAPDADRFRRR
What are the official names of this protein?
Uncharacterized protein MT3521.
What is the protein family that this protein belongs to?
To M.leprae ML0386.
Protein: RECO_BEUC1
Sequence: MKLYRDEAVVLRTHKLGEADRILTLLTRHHGQVRAVAKGVRRTSSKFGARLEPFGVIDLQLYAGRSLDVVTQVDTLAPHGRSIVGDYALYTTATAMVETAERLTEIEREPATQQYLLLVGALRALAERAHAPTLVLDSYLLRSLAVAGWAPTFTDCARCSREGPHRAFSAPMGGALCQACRPPGAAAPAAETFLLLGALLAGDWALADASDERHRRESSGLVAAYLQWHLERQLRSLRHVERA
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: ACPS_BACP2
Sequence: MIKGIGLDIVEINRLAHVLSRQPRLPERILTLNEQDIFHALSEKRQLEFLAGRFAAKEAFAKAYGTGIGRHLSFHDIEIQKDEHGKPFIKSEKTKDDQVHVSITHTKEYAAAQVLIERLSS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBEAG_WHV5
Sequence: MYLFHLCLVFACVPCPTFQASKLCLGWLWGMDIDPYKEFGSSYQLLNFLPLDFFPDLNALVDTATALYEEELTGREHCSPHHTAIRQALVCWDELTKLIAWMSSNITSEQVRTIIVNHVNDTWGLKVRQSLWFHLSCLTFGQHTVQEFLVSFGVWIRTPAPYRPPNAPILSTLPEHTVIRRRGGARASRSPRRRTPSPRRRRSQSPRRRRSQSPSANC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: PLSY_PARMW
Sequence: MLPFLRDPAACLVPVILTALLLLAIGYLLGSTPSGYLAGRWLKGIDLRDCGSGSTGATNVLRNVGKGPALVVFLIDVGKGALAVLLAKTFGLSDWLQVLAGLAALAGHIWPVWLGWKGGKAVATGFGMFLGLAWPVGLACFGLFMAVISIFRIVSLSSVVAAIGLPLLMVVSGGSSAYVVVSLVASLMVLWRHRSNIERLIAGTEPKIGQKA
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYE_PHOPR
Sequence: MTVKTRFAPSPTGFLHVGGARTALYSWLFAKHMGGEFVLRIEDTDLERSTQEAIDAILEGMEWLGMDWDEGPYYQTKRFDRYNQLVDQLLAEDKAYKCYCPKALLDELREEQMAAGVKPRYDANHPKIVAANAAATEDSAFCIRFRNPKEGTVVFEDKVRGRIEIANSELDDLIIRRTDGSPTYNFCVVIDDWDMGITQVVRGEDHINNTPRQINIYKAIGAPVPEFAHCAMILGDDGAKLSKRHGAVSVMQYRDEGYLPQALLNYLIRLGWSHGDQEIFSMEEMINLFSLESISKSASAFNTDKLLWLNNHYIKTAEPEYVAKYLQWHLEQKEIDTANGPKITDVIGLVGERCNTLIELADQSRYFYQDFSEFEAGAAKKHLRPVAKDALALVLSKVEALEEWNTENLHVVIADTCTELEVGMGKVGMPLRVAVTGQGQSPSVDATMMLIGKERVVNRITMALAFIAEREANA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_BORDL
Sequence: MAKSGKKYLQALSKVNKLKSYNIDDAISLLKEIKFVKFDETIDVSVNLNLKKNHTVRETLVLPHQFMKEKRILVFAKGEKAEEAREFGAAYVGDDDLINKIKDGFSDFDVVVATPDMMKDVGKLGPILGKRGLMPNPKTQTITNDLKGTIASLKKGRTEFRANKNGVINFSVGKSSMDSKKIRENYDEFIKELLKRRPSDLKGTFVDSVYVSSTMGPSVKIDFV
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: INT3_DICDI
Sequence: MMNQQQQQQQPPTTSPTQQQQLTQLQTHQYFQNKFKLFYKRELDEADPLEIYWRECYDKIELLLLNSSEAEINNYLIEKSASVESSGNNDQSNKFHTEVTIGFLYAILLGSPQNIALSHQYFKSLTFFTKDSLALFCSLLKKLIADKFQKLNDTPRQQVVWIINELIATNHQDCESVTSIILRHIYGGNFTSKNLSLSHSMLNMFLTHRQWLNSRPLLIPTILYNFLRLIQDHISRPQGLHNPTHLKDEINFCLDLLKNKFQECLVIGRDLIRLLQYLSTKTIEFEQLWKDLNSKPTTFAPGYYDIIQSMKTPTPKHFLQSRLSPEMELQVLYILKEVKFGNQKRYQQWFVTKYLVTPESESLIPDIIRYICCVYHPPNHVLCSDIVPRWAIIGWLLKHCKSDAWRNYSKLSLFLDWLYFEPKIDSIMNIEPAILLMAGSVKKYADMTIDLVEFIVGTLLDSYDIQRKDAIRQGIHNSFATVLEKGVVQSLSHVFPPDSLGPSLFEKVKHYFHQFLTNSPIHQLHSQQQQLQQQQLQQPQQPQQQQQPPQYKPYPQQPINKQLPLQMSPQQQSQQQLQQQQLQQQLQQQQQQQQPPQQPPPQQQPQQQPPQQQPQQQPQQQQPQLNISTGNLPNIQQPMVKSPPLSSNTLVSPTSSSSPTSSNLPTNNSRVLNKSGVDIHHVSNLSPQVISQKPQSQQTPSLHSSSQSVLQQKSPPLKETSLFEQQQPSQQLPSQIVKNSPPNLSMTNENISNPPPPPHAKISSDHASPLINSSNSNITTPNPDSQSQIPIPPPISQSPSTKNIDVIMSELNDEPPKLSKSSPTQSNIIVPPPTHKPPQTTISSSSPLLQPQTQPQPQTQPQPQTLQQSTTPSLSSSSTPTIPISPPLLPTQLEIDIQPPPPPPSSQPLQPPPPPPPSQNIKDETLNSLIELNSSIKLDEEIKMEIPDILLTIGSKPQFQPTNITITLGSILSNFNEKISKQPNITLQNELTDSLTQYLSQVLKPELQIDLSTTPSLLSLFCNFQVIHHIFRATFSPTDNSITTTTTTTAAATTTTTTTPTIVKPMFNILKELYKIYPSIGFKIMIWSIITSPGGLNITNNGCTYIYPDIECDNSFSNSDDNESTNNNNNGVEQKPQQQQQQQQQQQINENTHNNNNNNNNNNNNNNNNNNENNITNNSQNITIKEESIFKIEKLLESVQDSNGNRNILGNYLNFHSNLLGGQPPPPPPPQQPNKIVEQIISDCIEANNVGAFNYLVPILYKSFSNLLVGNSDFLYLVLSCINPRQHFRICNKISMGEFRVFGNEMKSLISQSFKWESFEQNYLWQMLIAEDSVYSGMIVKEYPFIISKLDPYNNSEVLQNLTITLKETKFYDFNIFSETLLLNDYFYTFVFCLFSFWLKNNTTQTFNYINQIFDFYLSNNNNNNNNNRKLVERILYFYNIFLKKYGEERIKWSDMIDSDRVSKVLQRSTNSNLFQKYSNLGSLVLPSQSSNIKNDNNPTLSKHQNSDDDSNPKKRFRKE
What are the official names of this protein?
Integrator complex subunit 3 homolog, SOSS complex subunit A homolog.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 3 family.
Protein: DAPE_HAHCH
Sequence: MTDSLSPTLELAVELIKRPSVTPHDAGCQELLSQRLQTIGFEITDLPFGEVQNFWARRGSQAPLVVFAGHTDVVPTGPEEKWEHPPFAAEVKDGVLHGRGAADMKGSLAAFMTACERFVKKHPNHRGSIGWLITSDEEGHAVNGTVKVVEYLVDKGEVIDWCIVGEPSSTHTVGDVIKNGRRGSIGATLIVKGVQGHVAYPHLADNPIHKAAPALAELANEKWDEGNAFFPATSLQISNINGGTGATNVIPGELNIMFNLRFSTELNADVIKQRSEAILQKHGLDYDIEWRLYGEPFLTSKGPLIEATQKAIKHVRGSDTTLSTSGGTSDGRFIAPTGAQVVELGPCNATIHRINEQVLVSEIDQLSSIYEHILEELLVVGSE
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: CODY_STRTD
Sequence: MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYIRGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLHLQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLNEGIYDKLKEYE
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_SALPK
Sequence: MRQLLPGDTVWRNIRLATMDPQRQAPYGLVDNQALIVREGHICDIVPETQLPVSGDNIHDMQGRLVTPGLIDCHTHLVFAGNRAAEWEQRLNGASYQHISAQGGGINATVSATRACAEETLYQLARERMMRLASEGVTLLEIKSGYGLELATEEKLLRVAAKLAAENAIDISPTLLAAHATPAEYRDDPDGYITLVCETMIPQLWKKGLFDAVDLFCESVGFNVAQSERVLQTAKALGIPVKGHVEQLSLLGGAQLVSRYQGLSADHIEYLDEAGVAAMRDGGTVGVLLPGAFYFLRETQHPPVELLRRYQVPVAVASDFNPGTSPFCSLHLAMNMACVQFGLTPEEAWAGVTRHAARALGRQATHGQLRAGYRADFVVWDAEQPVEIVYEPGRNPLYQRVYRGKIS
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y209_FINM2
Sequence: MKNYTELLKSELIMALGCTEPISIALAAAKAREVLGDIPTKIEVKCSGNIIKNVKGVTVPNTNGMKGVEAATAIGTVAGDSSLGLEVLSKVTDEDIKAAKCMLDNNIIKVSLKEGVENLDIEIVAEDDKENTVDVEIKNKHTNIVKVTKNDKVIHIDNCYTHTPEYENYDELSVKDIFEYANNVDLDEVRDLLEDQITLNSKISDEGLTGKWGVAMGKILMDEDDSIRSKAKARAAAGSDARMSGCSLPVVINAGSGNQGITCTMPLVVFANEKNYDRETLYRGLLITNLVALHIKRFIGRLSAFCGVTSAGVAAGAGICYMETKNLDLIEKTIGNALMIASGMICDGAKPSCAAKIATAVDAGISGYYLAKNNRNFEAGDGLLKDDIEETIRSIGYVAKEGMKETDIVVLHTMIEK
What are the official names of this protein?
UPF0597 protein FMG_0209.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: GLYC_MACHU
Sequence: MGQLISFFQEIPVFLQEALNIALVAVSLIAVIKGIINLYKSGLFQFIFFLLLAGRSCSDGTFKIGLHTEFQSVTLTMQRLLANHSNELPSLCMLNNSFYYMKGGVNTFLIRVSDISVLMKEHDVSIYEPEDLGNCLNKSDSSWAIHWFSNALGHDWLMDPPMLCRNKTKKEGSNIQFNISKADDVRVYGKKIRNGMRHLFRGFHDPCEEGKKCYLTINQCGDPSSFDYCGMDHLSKCQFDHVNTLHFLVRSKTHLNFERSLKAFFSWSLTDSSGKDMPGGYCLEEWMLIAAKMKCFGNTAVAKCNQNHDSEFCDMLRLFDYNKNAIKTLNDESKKEINLLSQTVNALISDNLLMKNKIKELMSIPYCNYTKFWYVNHTLTGQHTLPRCWLIRNGSYLNTSEFRNDWILESDHLISEMLSKEYAERQGKTPITLVDICFWSTVFFTASLFLHLVGIPTHRHLKGEACPLPHKLDSFGGCRCGKYPRLRKPTIWHKRH
What is the function of this protein?
Interacts with the host receptor (By similarity).  Mediates virus attachment to host TFRC.  This attachment induces virion internalization predominantly through clathrin-mediated endocytosis (PubMed:17287727).
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: GPI8_MOUSE
Sequence: MAAPCFLTLRVATLAALALLSLGSSAAGHIEDQAEQFFRSGHTNNWAVLVCTSRFWFNYRHVANTLSVYRSVKRLGIPDSHIVLMLADDMACNARNPKPATVFSHKNMELNVYGDDVEVDYRSYEVTVENFLRVLTGRVPPSTPRSKRLLSDDRSNILIYMTGHGGNGFLKFQDSEEITNIELADAFEQMWQKRRYNELLFIIDTCQGASMYERFYSPNIMALASSQVGEDSLSHQPDPAIGVHLMDRYTFYVLEFLEEINPASQTNMNDLFQVCPKSLCVSTPGHRTDLFQRDPKNVLITDFFGSVRKVEITTEKISLQWDSQVVDSSSKEDGTAEERMGPLKYAEQLPVAQIIHQKPKPRDWHPPGGFILGLWALIIMVFFKTYGIKHMKFIF
What is the function of this protein?
Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI.  During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity).
What are the official names of this protein?
GPI-anchor transamidase, GPI transamidase, Phosphatidylinositol-glycan biosynthesis class K protein, PIG-K.
What is the protein family that this protein belongs to?
Belongs to the peptidase C13 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: DAPB_PASMU
Sequence: MTLRVAIVGAGGRMGRQLIQAVSETEGVVLGAAFERQGSSLLGADAGELANVGHLGVQITDDLASQQDQFDLLIDFTRPEGTLAHLAFCVAQHKNMVIGTTGFDDDGKAKIQQAADSIGIVFASNFSVGVNLVFKLLEKAAKVMGDYCDIEIIEAHHRHKVDAPSGTALSMGEHIAKTLGRDLKTHGVFTRDGITGERKRDEIGFATIRASDVVGEHSVWFADIGERVEIAHKATSRMTFAKGAVRAAKWLAQKEKGLFDMTDVLDLNQL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTXI5_MESEU
Sequence: MCMPCFTTDPNMANKCRDCCGGGKKCFGPQCLCNR
What is the function of this protein?
Toxin with unknown function in healthy organisms.  On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells.  This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation.
What are the official names of this protein?
Insectotoxin-I5, BeI5.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRP18_SCHPO
Sequence: MDFLKEEIERKRRQLEGTSELPVKKAFRRGDWEKEREKKYLQEKQQKDEQRELKKRKLEEERLKYEEKKLRISRLANKESSRNEELLTETTTPSPAVKASPASTKLSVSENDRLSIPEITKDNLTLTEIIAKLREMKEPIRLFGESEEATIQRYYSLLKYKKLEEIENELLTKGVETIDFEHATTTKPKVSKQVVAFLQHGIRIWDNFLSSKSINSFESSESQMQLKIFRQAKQDLDVLIQLIVDEALNDDIFKSIAEICYRCQKHEFVKANDMYLRLTIGNAPWPIGVTMVGIHERSAHQRLQANPSSNILKDEKKRKCLQALKRFITFQERESSNLPEYTD
What is the function of this protein?
Participates in the second step of pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor 18.
What is the protein family that this protein belongs to?
Belongs to the PRP18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GP1D_CHLPS
Sequence: MIKQSEEEKDLLDVEFFVLGQAVNYLEHAHVVVRRLSEHHFKSENHKNIFLLIRDILRDRDTISISLIWEEIKRRNLDKSMDVSYLIHMSQNADIPIDLDHHIDFLHEKHVNNLLKEFLDSSFQDFTRYPNRRSPYTLIDQFKERLDDIYEKTSYPRRKHIGKTVYDIFSSGENGKASVIAQIRHRYDYRSRHKIDYVDGLPTGYSSIDEHSIILSRGNFVVIAARPAMGKTAFAIDIALNLVLEQGKAVGFISLEMSPNQIVERIISNLSETSCEQLKRGNFSRDVLSKIESIGTKLKGTHFFICDNKSTDLNTLIDQARELRENQGIDALFIDYLQLIGSSKKAENRQNEIAEISRQLRKLAVELQIPVVCLSQLSRKVEDRGDKRPMLSDLRDSGQIEQDADVILFLHRKDYYSQEATKGLSEIIVGKNRHGSVFSTTLRFNSCTGKFTIQKEAW
What are the official names of this protein?
Probable plasmid replicative DNA helicase, DnaB-like protein, Virulence plasmid protein pGP1-D.
What is the protein family that this protein belongs to?
Belongs to the helicase family. DnaB subfamily.
Protein: PURA2_CHRVO
Sequence: MSKNVVVIGTQWGDEGKGKIVDWLTDHARAVVRFQGGHNAGHTLWVNGKKTVVRLVPSGILRPDVECFIGNGVVLSPEALLKEIDELEAAGVNASARLKIAEGCPLILPYHIALDQAREAAKGDAKIGTTGRGIGPCYEDKVARRALKVIDLFDPARFETKLKENVDYYNFLLTNLFKAEPVSYEAILADTMKMAERIKPMVADVSRTLYDLDKAGTPILFEGAQGTLLDIDHGTYPYVTSSNCVAGAAAPGAGVPPQMLNYVLGIVKGYATRVGSGPFPTEQENEIGAFLAKRGNEFGSVTGRPRRCGWFDAAALKRSIQINGVSGLCVMKLDVMDGLEEIKLCTGYMLDGQKVDILPFGSDAVTKCEPVYETLPGWTGTTVGVKRWEDLPANAQAYLKRIEEVCGAPVDIVSTGPDREETIVLRHPFGL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase 2, AMPSase 2, AdSS 2, IMP--aspartate ligase 2.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP50_BPAPS
Sequence: MKIKLNNVRLAFPELFEPTQVSGQGAFKYRANFLIPKSRTDLIEEIKAGIKHVIGEKWGNKDIEKIYNSICNNPNRFCLRDGDSKEYDGYAGNLYLSASNKSRPLVIDRNTSPLTAQDGRPYSGCYVNATVEFYGYDNNGKGVSASLRGVQFFRDGDAFTGGGVASVEEFDDLSMAEEEELLAS
What are the official names of this protein?
Putative protein p50.