PharMolix/UniProtQA huggingface dataset:
Protein: NADD_PARD8
Sequence: MGLKTGIYSGSFNPIHIGHLALANWLCEFEGLDEVWFVVTPHNPLKKKDDLLDDSLRLEMAQAAIDGYPKFRVCDIEFYLPKPSYSIDTLRTLSRNYPNRDFYFIMGADNWQLFPRWKEHEKILQDYKLLIYPRLGFDISIPAIYPNVKKVDAPLMEISSTFIRNAYQADKDIRFFLPEGVRPYYYKI
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: KDD_FUSNN
Sequence: MKKGCKYGTHRVIEPAGVLPQPAKKISNDMEIFSNEILIDVIALNIDSASFTQIEEEAGHDVEKVKAKIKEIVAERGKMQNPVTGSGGMLIGTVEKIGDDLVGKTDLKVGDKIATLVSLSLTPLRIDEIINIKPEIDRVEIKGKAILFESGIYAVLPKDMPENLALAALDVAGAPAQVAKLVKPCQSVAILGSAGKSGMLCAYEAVKRVGPTGKVIGVVRNDKEKALLQRVSDKVKIVIADATKPMDVLHAVLEANDAKEVDVAINCVNVPNTEMSTILPVKEFGIAYFFSMATGFSKAALGAEGVGKDITMIVGNGYTVDHAAITLEELRESAVLREIFNEIYL
What is the function of this protein?
Involved in the anaerobic fermentation of lysine.  Catalyzes the oxidative deamination of L-erythro-3,5-diaminohexanoate (3,5-DAH) to 3-keto-5-aminohexanoate (KAH).  It can use NAD or NADP.
What are the official names of this protein?
L-erythro-3,5-diaminohexanoate dehydrogenase, 3,5-diaminohexanoate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the KDD family.
Protein: Y1848_IDILO
Sequence: MFKGGMGNMMKQAQQMQERMQQAQEEVANMEVTGEAGAGLVKITMLGNHNVKRVSIDPSLMEDDQEMLEDLIAAATNDAVRRVEETSKERMSEITGGMGLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein IL1848.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: AP1M1_BOVIN
Sequence: MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTQ
What is the function of this protein?
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes.  The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
What are the official names of this protein?
AP-1 complex subunit mu-1, AP-mu chain family member mu1A, Adaptor protein complex AP-1 subunit mu-1, Adaptor-related protein complex 1 subunit mu-1, Clathrin assembly protein complex 1 mu-1 medium chain 1, Golgi adaptor HA1/AP1 adaptin mu-1 subunit, Mu-adaptin 1, Mu1A-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: GLYA_PHYMT
Sequence: MNQEINNFYIKDQEIFDQIKLEEKRQKESINLIASENFVSQDVLKVQGTILTNKYAEGYPEKRFYNGCQYIDEIEKIAIERATELFKAKYANVQPHSGSQANMAVFQALLNPNDRILGLSLSDGGHLTHGSKMNFSGKYYESYFYGLNSKTETIDYAEVEKIAFAIRPKLIITGYSSYSKIIDFKSFRKIANKVNAYLMADIAHISGLVASGLHPCPLEAQADVVTSTTHKTLRGPRGGLILTNNKEIINKINKAVFPGGQGGPLMHIIAAKAVAFKEALHSDFIKYQKQILKNACFFAENLQKKGYRIISKSTENHLFLVDVKSKNPNFTGKKISDILNKVNIVVNKNVIPFDKETPLITSGIRLGTPAMTTRGFKENEFAKVSDFIDEAITNHNDLNYLNNLKQKVITLSKNFPLKI
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TET11_ARATH
Sequence: MFRVSNFMVGLANTLVMLVGASAIGYSIYMFVHQGVTDCESAIRIPLLTTGLILFLVSLLGVIGSCFKENLAMVSYLIILFGGIVALMIFSIFLFFVTNKGAGRVVSGRGYKEYRTVDFSTWLNGFVGGKRWVGIRSCLAEANVCDDLSDGRVSQIADAFYHKNLSPIQSGCCKPPSDCNFEFRNATFWIPPSKNETAVAENGDCGTWSNVQTELCFNCNACKAGVLANIREKWRNLLVFNICLLILLITVYSCGCCARRNNRTARKSDSV
What is the function of this protein?
May be involved in the regulation of cell differentiation.
What are the official names of this protein?
Tetraspanin-11.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: P2A02_ARATH
Sequence: MRVKRRKTVSCCTREISQLHGQSLKQINIGVGSLILTKHQGYEFYCKKVTFVFFCFFKISLNSAYLYTLYSDVRTEVAKMERVAWLEVVGKFETEKLTPNSLYEVVFVVKLIDSAKGWDFRVNFKLVLPTGETKERRENVNLLERNKWVEIPAGEFMISPEHLSGKIEFSMLEVKSDQWKSGLIVKGVAIRPKN
What are the official names of this protein?
Protein PHLOEM PROTEIN 2-LIKE A2, AtPP2-A2.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CP2E1_MOUSE
Sequence: MAVLGITVALLVWIATLLLVSIWKQIYRSWNLPPGPFPIPFFGNIFQLDLKDIPKSLTKLAKRFGPVFTLHLGQRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARIQREAHFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYDDKKCLELMSLFNENFYLLSTPWIQAYNYFSDYLQYLPGSHRKVMKNVSEIRQYTLGKAKEHLKSLDINCPRDVTDCLLIEMEKEKHSQEPMYTMENISVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRAPAVRDRMNMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFRGYVIPKGTVVIPTLDSLLFDNYEFPDPETFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTIGFGSIPREFKLCVIPRS
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids.  May be involved in the oxidative metabolism of xenobiotics.
What are the official names of this protein?
Cytochrome P450 2E1, 4-nitrophenol 2-hydroxylase, CYPIIE1, Cytochrome P450-ALC, Cytochrome P450-J.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Note=Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein.
Protein: ENGB_BUCBP
Sequence: MYLVDTIDYQKICCIIKTFEDNILFQKNYHSTWFLKSIANIQKEKYNYGLEVAFVGYSNSGKSSIINALTNQKKLAKISRTPGRTRLINIFSVTSEIRLVDFPGYGYAQVSRSISKKWKEMIFQYLNIQKCLQGLVIITDIRCPIKEIDELVINLAVSLNIPILLLLNKMDKVTRSIQKSKLFSTREKMLNFSNNINVELFSSFKKIGIHKLQFVLNNWFSSDKKLCQ
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: MEND_GLOC7
Sequence: MTIDFRNVNTLWASILVETLHRLGLTTAVICPGSRSTPLTIAFANHSNIEAIPILDERSASFFALGIAKKSGLPVVLVCTSGTAGANFYPAVIEAKESHVPLLILTADRPPELRHCHAGQTIDQVKLYGNYPNWQTEIAVPSAEEGMINYLRQTLIYAWERSLFPARGVVHLNLPFREPLAPIPNSDTEKIQFNFDVENFFTEINLLNFPSSNRIEKYEKIIPKWQLFQRGIIIAGVDHSYNPQEYCRAIARLSEFLKYPVLGEALSPVRNYAALNPYLISTYDLILRNSSLAENLKPDIVIQIGELPTSKELRTWLDITQPPRWIIDNKGENLDALHGKTIHLRTSIEQLANSLSFKETISNSPYLKLWCDTEKKVRKTIDQTLESIDSLLEGKIAWLLSQTLPENTPIFIANSMSVRNAEFFWQPNNFKYIPYFNRGANGIDGTLSTALGIAHHHQSSVMLTGDLALLHDNNGFLINKKFRGHLTIILVNNDGGGIFEMLPIAQFDPYFEDFFATPQTVNFGKLCLAYGIDHYLIQDWQQLKQLLNPLPETGIRVLELNTNRKLDAEWLKTNLSKFSLT
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: MBSP_SAUUN
Sequence: IVGGYECEAYSKPYQVSINLGY
What is the function of this protein?
Serine protease which degrades the myosin heavy chain and tropomyosin, but not actin.  Selectively cleaves Arg-|-Xaa bonds.
What are the official names of this protein?
Myofibril-bound serine protease, MBSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_CALS4
Sequence: MINLTVKIAIDGPAGAGKSTVAKKLAKLLGFTYIDTGAMYRAITLKVLRENISLEDEERIVEVARKSDISLDGERVFLDGEDVSEEIRKPIISQKVSVVSQIPEVREILVKKQRKIAEGKNVVMDGRDIGTVVLPDAQFKFFLTASLEERARRRYEELKNKGTEVKYEEVLEEIKKRDSLDSGRKTSPLTIPEGAILIDTTDLTEEEVVERVYEAIRKNTKGEI
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1433B_SHEEP
Sequence: MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAG
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.  Negative regulator of osteogenesis.  Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.  Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
What are the official names of this protein?
14-3-3 protein beta/alpha, Protein kinase C inhibitor protein 1, KCIP-1.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm. Melanosome.
Protein: UXUA1_BACLD
Sequence: MKMVFRWYGEGNDSVTLEQIRQIPGVEGIVWALHHQPPGEEWPLEEILEVKRQCEQHGFHIEVVESVNIHEDIKLGLPTRDLYIEKYKRTIENLAKAGVKVICYNFMPVFDWLRTDLYKKAPDGSTALFYEHAKVHTIDPFALVDQIAKHPEFTMPGWEPERLEHLTRLFEAYQNVTEEDLWSHLHYFLERIIPTAARCGIKMAIHPDDPPWPVFGLPRIMTSGESIGRLLQLVDHPANGVTLCSGSLGANPENDISAMIHAYADRIPFAHIRNVKVYENGDFIETSHRTKDGTVDICGIVKAYHETGFSGYVRPDHGRHIWDEKCRPGYGLYDRALGIMYLWGIWDSLNREKQEASKCLKSMKI
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase 1, D-mannonate hydro-lyase 1.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: DISA_BACHK
Sequence: MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: YFFB_LACLA
Sequence: MKLSSGWEQSVYVLLILARLPENRTMSSIALANRLKVSPSYLKKIIKSLVDEGLLRSTPGKNGGFSLNKELHDISFYDVFLAIEGRGRIFQSQGLLQNFIGSESGKAKRCAITSALDEIENTLVRTLSNVSLAQVADETQYNYNLGYLDEWIDEMD
What are the official names of this protein?
Putative HTH-type transcriptional regulator YffB.
Protein: DUSP_VACCW
Sequence: MDKKSLYKYLLLRSTGDMHKAKSPTIMTRVTNNVYLGNYKNAMDAPSSEVKFKYVLNLTMDKYTLPNSNINIIHIPLVDDTTTDISKYFDDVTAFLSKCDQRNEPVLVHCAAGVNRSGAMILAYLMSKNKESLPMLYFLYVYHSMRDLRGAFVENPSFKRQIIEKYVIDKN
What is the function of this protein?
Serine/tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses.  Dephosphorylates the OPG144 protein.
What are the official names of this protein?
Dual specificity protein phosphatase OPG106, Dual specificity protein phosphatase H1L, Late protein H1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Approximately 200 molecules of H1 are packaged within the virion and are essential for the viability of the virus.
Protein: MAP21_NEOFI
Sequence: MAAQVTEKLQDLHLNGQNGDAKANSTAVGQTEAGEAEDDSDDEKEDGNAAPEAGAGGAAKKKKRKSKKKKKGGAKVQSSPPRVPVSNLFPNNQYPEGEIVEYKNENSYRTTNEEKRYLDRMNNDFLQEYRQAAEVHRQVRQYAQRTIKPGQTLTEIAEGIEDAVRALTGHQGLEEGDNLKGGMGFPCGLSINHCAAHYTPNAGNKMVLQQGDVMKVDFGAHINGRIVDSAFTMTFDPVYDPLLEAVKDATNTGIREAGIDVRMSDIGAAIQEAMESYEVELNGTMYPVKCIRNLNGHNIDQHIIHGGKSVPIVKGSDQTKMEEGETFAIETFGSTGKGYVREDMETSHYALIPDAPSVPLRLSSAKNLLNVINKNFGTLPFCRRYLDRLGQEKYLLGLNNLVSSGIVQDYPPLCDVKGSYTAQFEHTILLRPTVKEVISRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-1, MAP 2-1, MetAP 2-1, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_METMJ
Sequence: MAPEKSLERATFGAGCFWGVEEAFRRVPGVVETAVGFMGGTVENPTYPEVCTGRTGHAEVVQVTYDPGTVSYRALLDTFWDAHDPTTPNRQGPDIGTQYRSVIFVHTPEQEAEARASKEEMDQSGKFRRPIVTAIEPAGTFWRAEEYHQQYFAKRGGGQCRTVW
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: IDI2_LEGPH
Sequence: MQNEYSQFEQRKRDHIELALMPANQSSELNPFDHFSLVHEALPDLDFKDISIQSIRFKKPVEKPFIISSMTAGHSNALEINYRLMEACSKTKWAMGVGSQRRELTDKQAAFEWTPLRRDFPMVSLFSNLGIAQLIDTPISAIQRLIDTLQAEALIIHCNPLQECIQPEGTTNFQGCWTALEALVKKIASPVIIKETGCGFSKNTLLRLNNIGVAAVEISGVGGTHWGRIEGHRANKDPIRQRTADTFRNWGIDTLQSTRNAISLNPSFEIWGSGGVRNGLDAAKLFALGATTVGFAKPMLEAALGSTGQVLTQMNTIEYELKTAMFCTGSRVLDDLKEKACP
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_PSEAE
Sequence: MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGSSSSKEPAAKGRKSASEAPALSPKEKARRQLVSRMGVDPEHGWKAKYEILPGKEKVIDELRRLAKDADTVYLATDLDREGEAIAWHLREAIGGDESRYKRVVFNEITKKAIQEAFSQPGELDINRVNAQQARRFLDRVVGYMVSPLLWQKIARGLSAGRVQSVAVKLVVEREREIRAFVPEEYWEVHADLGTAKGANVRFEVTREKGEAFKPLNEAQAMAALEKLKASAYSVAKREDRPTSSRPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAIGMVRGFIEDEFGQKYLPGKANVYSSKEGAQEAHEAIRPSDVNLKPTQLSGMERDAERLYDLIWRQFVACQMTPAEYLSTSVSVTAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMKEGENLKLIKLDPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQERGYVTTHNRRFYAEKMGDIVTDRLNESFANLMDYGFTAGMEEHLDDVAQGERDWKHLLDEFYGDFKKKLEVAEVSEKGMRANQPTLTNIPCRECGRPMMIRTASTGVFLGCSGYSLPPKERCKATVNLIPGDEIAADDEGESESRVLRGKHRCPICSTAMDAYLLDEKHKLHICGNNPDCPGYEIEEGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKNGEAAPPKMDAIRMPELKCEKVDDIYVLRDGASGMFLAASQFPKNRETRAPLVSEIIPHKAELDPKYHYLCDAPQKDPDGRPAVIRFSRKTKEQYVQSEVDGKPTGWRAFYDGGKWKVEDKR
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: ASSY_ACIET
Sequence: MATILQHLPVGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEADYDEIPRKAMEYGAEKARLIDCRTQLAHEGIAAIQAGAFHISTGGITYFNTTPLGRAVTGTMLVAAMKEDDVHIWGDGSTFKGNDIERFYRYGLLTNPALKIYKPWLDQKFIDELGGRAEMSAFMTKEGFGYKMSAEKAYSTDSNMLGATHEAKDLEFLSSGIRIVNPIMGVAFWKPEVDVPAEEVSVTFDEGQPVAVNGKEIADPVELFLELNRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQYRLNGLKLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTVTLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPLDRIGQLTMRNLDISDTRGKLGVYARAGLLSLGGNAALAQLEDGGAKKK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPH_STRM5
Sequence: MSDSRPSGRQPDQLRPVVIQRGFTRHAEGSVLVCFGETRVLCTASVENRVPGFLRGKGEGWVTAEYGMLPRATHTRSDREAARGKQGGRTLEIQRLIGRSLRACVDRNALGERTITLDCDVLQADGGTRTAAITGAYVALVDAVNVLMKRGDIKRNPILGAVAAVSVGVYRGTPVLDLDYAEDSDCDTDMNVVMNDGGGFIELQGTAEGHAFRRDELDALLGLAEKGVRELLDAQQAALSA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: COBS_LISMO
Sequence: MKTLILLIQFFTRIPLPIQINMDEINLKKGSALLPFVGVIIGAWNWLIFTLVALVMPLPVAIIAGLFAEVIITGGFHVDALADTADGLFSSRKRERMLEIMKDSRVGANGVIAICFYFLFYGALFLSVTDTQQICWLFFVLPIVAKGVTMLLFAKMTYAGSKEGLGSIFLGVPWWPIVIAQVIVLAVLGLFFSYVGVIAYVGVILFTIIYRAFVYKRIGGMNGDTLGAGGQMGQLICLFCLVLLWGLV
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SEPF_PROM9
Sequence: MSLISRLKAVVAGDEYLDDDFDELDYATEDELNDINDFKQTQRNSNALANSNPFDFMNNNRSSKVVGMPGISNSSSEVSLMEPRSFDEMPQAIQALRERKTVILNLTMMDPDQAQRAVDFIAGGTYAIDGHQERVGESIFLFAPSCVNVTSSSPEEASPSSVSPKNTPQYSVENNTAPEPAWGNSKLSAFS
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: FLGI1_YERPE
Sequence: MSVLIKTRHCFVLLGLWLVLPTASAQPLGSLVDIQGVRGNQLVGYSLVVGLDGSGDKNQVKFTGQSMANMLRQFGVQLPEKMDPKVKNVAAVAISATLPPGYGRGQSIDITVSSIGDAKSLRGGTLLLTQLRGADGEVYALAQGNVVVGGIKAEGDSGSSVTVNTPTVGRIPNGASIERQIPSDFQTNNQVVLNLKRPSFKSANNVALALNRAFGANTATAQSATNVMVNAPQDAGARVAFMSLLEDVQINAGEQSPRVVFNARTGTVVIGEGVMVRAAAVSHGNLTVNIREQKNVSQPNPLGGGKTVTTPESDIEVTKGKNQMVMVPAGTRLRSIVNTINSLGASPDDIMAILQALYEAGALDAELVVI
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein 1, Basal body P-ring protein 1.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.