PharMolix/UniProtQA huggingface dataset:
Protein: COE3_XENLA
Sequence: MFGIQENIPRGGTTMKEEPLGGGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEIERTTFVDFVEKDKEPNSEKTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTAPSYLENVATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPSLANTPSHSGMMGVNSFSSQLAVNVSETSQANDQVGYSRNTSSVSPRGYVPSSTPQQSNYNTVSNSMNGYGNAGMPNLGVPGSPGFLNGSSANSPYGIVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAVKQKSAFAPVVRPQASPPPSCTSANGNGLQDMYFSPTFSKS
What is the function of this protein?
Acts as a transcriptional activator.
What are the official names of this protein?
Transcription factor COE3, xCOE3, Olf-1/EBF-like 2, OE-2, xEBF-3, xOE-2.
What is the protein family that this protein belongs to?
Belongs to the COE family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPE_HERAR
Sequence: MVRTLNNCPAPAKLNLFLHVTGRRADGYHLLQSVFQLIDRGDVLHFSVRDDGLIHRSTELAGVPADSDLVVRAARLLQTEAKKQGKTPGADIAIEKKLPMGGGLGGGSSDAATTLLALNHLWQTGLTRAELMALGLQLGADVPFFLFGQNAFAEGIGEALMAVKTPESWFLVIEPGVSVPTQQIFSSLELTRDTKPVKISDFSRAQESFGKNDLQVVAANLFPPIADAIKWLQQFGDARMTGSGACVFCPFKEEQQVDAVLATVPQQWKAWKAKAITHHPLAYLAT
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: CMOB_PSE14
Sequence: MIDLAPLARRLAGTPLADWANGLQAQLDTKMAKGHGDLQRWQSALDALPDLQPERIDLLDSFTLQAECNGETRTVLRKALLGLSPWRKGPFNVFGVHIDTEWRSDWKWSRVSPHLDLKGKRVLDVGCGNGYYQWRMLGAGADSVIGVDPNWLFFCQFQAMQRYLPDLPAWHLPFALEDLPANLEGFDTVFSMGVLYHRKSPIDHLLALKDCLVKGGELVMETLVVPGDVHQVLVPEDRYAQMRNVWFLPSVPALELWMRRAGFTDVRCVDVSHTTIEEQRSTEWMRFQSLSDYLDPADHSKTVEGLPAPMRAVIVGRKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: PSTC_ECOLI
Sequence: MAATKPAFNPPGKKGDIIFSVLVKLAALIVLLMLGGIIVSLIISSWPSIQKFGLAFLWTKEWDAPNDIYGALVPIYGTLVTSFIALLIAVPVSFGIALFLTELAPGWLKRPLGIAIELLAAIPSIVYGMWGLFIFAPLFAVYFQEPVGNIMSNIPIVGALFSGPAFGIGILAAGVILAIMIIPYIAAVMRDVFEQTPVMMKESAYGIGCTTWEVIWRIVLPFTKNGVIGGIMLGLGRALGETMAVTFIIGNTYQLDSASLYMPGNSITSALANEFAEAESGLHVAALMELGLILFVITFIVLAASKFMIMRLAKNEGAR
What is the function of this protein?
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Phosphate transport system permease protein PstC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGR_YERPY
Sequence: MRNPAKQEDLIKAFKALLKEEKFSSQGEIVLALQEEGFENINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDVDYNDSVVVINTSPGAAQLIARLLDSLGKAEGILGSIAGDDTIFTTPARGFTVKQLHEAILRLFEQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C3HPD_PSEAE
Sequence: MKHAHLIVPRTLVAGSASGELLYAPTGLSFWGGVDPRSAEVIDRHHPLSGRHLHGRLLAIPGGRGSCTGSSVLLELILGGRAPAAILLREPDEILALGAIVAEELFGRSLPIACLGERFDELAAYPWARLADGRLELHRDAPPPLEARPAEALATDAGPRLDAFDQALLAGEHGEAARLAMRIVLRMAALQGAQRLIDIQRAHIDACIYTGPAGLRFAETLRDLGARVRVPTTLNAISVDQRRWREQGVPAALGEPAAALARAYLDMGAQPSFTCAPYLLDDSARAGEQIVWAESNAVLFANSVLGARTNKYADFMDICCALTGRAPLAGCHLDEQRQARVLIEVEDLGSVDDAFYPTLGYLCGLLCDGQIPAIDGLRQRQPDHDALKAFGAALGTSSSVPMFHVIGVTPEAPDLASAFGGRAPRRTLRVGRERLRDAWRELDSAGETRIDLVALGNPHFSASEFAQLAALCHGRRRHPEVALVITSSRQVVAQAEAAGHLATLQAFGARLVTDTCWCMLDEPLVPPGARTLMTNSAKYAHYAPGLVGRQVRFAGLAGCVEAAVGGRSPAGLPAWLSEDC
What is the function of this protein?
Catalyzes the dehydration of cis-3-hydroxy-L-proline (c3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C).  Has also activity with (2S,3S,4R)-3,4-dihydroxyproline as substrate, albeit at about 300-fold lower rate.  No activity with L-proline, trans-4-hydroxy-L-proline (t4LHyp), cis-4-hydroxy-L-proline (c4LHyp), trans-3-hydroxy-L-proline (t3LHyp), D-proline, cis-4-hydroxy-D-proline (c4DHyp), trans-4-hydroxy-D-proline (t4DHyp) or L-serine as substrates.  No hydro-lyase activity with citrate or cis-acotinate.  Does not catalyze 2-epimerization of c3LHyp to trans-3-hydroxy-D-proline (t3DHyp).  Involved in a degradation pathway that converts c3LHyp to L-proline, which would allow P. aeruginosa to grow on c3LHyp as a sole carbon source.
What are the official names of this protein?
Cis-3-hydroxy-L-proline dehydratase, c3LHyp dehydratase, c3LHypD, Aconitase X, AcnX, PaLhpI.
What is the protein family that this protein belongs to?
Belongs to the aconitase X family.
Protein: TPIS_METLZ
Sequence: MSSPLILVNFKSYREGAGNAAGQIASAAELVMQESGVTIGIAPQFVELHPFCKHYEIPVYAQHIDAVEGAFTGRIPAFTVRAAGCVGSLINHSERRLTIAEIEACVEAAKFNHLESVVCTNNVGVSAAAAAFSPTYVAVEPPELIGSGISVAKADPDIIRNSVAAVKKISSDVKVLCGAGIQSGECVKTAVDLGADGVLLASSVVKAKDPEAVLRDLVSLL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_LACAC
Sequence: MVMTDPIADYLTRIRNANMAKHDSVEIPASNIKKSISEILKREGFIRDYEVADDNKQGVIKVFLKYGPNGERVISGLKRISKPGLRNYVSAEDLPKVLNGLGIAIVSTSAGVITDKEARQKNVGGEVVAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: MURD_PARPJ
Sequence: MFGEKFRDRQKPMVLVLGLGESGLAMARWCARHGCRLRVADTREVPPNLPALEAHGIDAAFVGGPFSPVLLEGVELVAISPGLSPLAADLVPLISAAREQGIPVWGELELFSQALKALGESGYAPKVIAITGTNGKTTTTSLTGLLCERAGKKVAVAGNISPALLDKLSEAIDNTALPDVWVLELSSFQLETAHTFTPDAAVVLNITQDHLDWHGGLDAYAAAKGRIFGAQTVRVLNRDDSRVMKLAPAEDSEAEMVTFGVTEPKNDGDYGLLRDNGMIWLVQAHDRDATDEPVPKRRRKNEVVTPPNIALKRLMPADALRIRGLHNAANALAAYALTRAIGLPGAPLLHGLREYRGEPHRVELIASIDGIDYVDDSKGTNVGATVAALDGLAQRIVLIAGGDGKGQDFEPLAAPVMRWCRAVMLIGRDAPLIRAALEDTGIAMTDHATLEEATRAATALAEPGDAVLLSPACASFDMFKGYAHRAAVFRSTVEDIAAERGTMI
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO4_SHELP
Sequence: MKKIIHVDMDCFFAAVEMRDFPELRGKPIAVGGRSDRRGVISTCNYEARKFGVRSAMASAYALKLCPDLILVPGRMSVYKEVSAQIREVFARYTELIEPLSLDEAYLDVSDCTQHQGSATLIAEAIRREIFEVTGLTASAGIAPVKFLAKIASDLNKPNGQYVITPQMIPEFVKTLALIKIPGVGKVTAAKLETMGLITCADVQACSRQSLMERFGKFGGVLYDRAQGIDPRGISPHRERKSVGVETTLAKDIYTYEQCQAVMPQLIQELSGRISRSAKSRRIHKQVVKLKFDDFKQTTIEQRSDEVSVKLFYDLLKQALERRAGRGIRLLGVSVGLESEAVGAGLDEEVHGAQMDLGF
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIS1_LACTC
Sequence: MSLISAAADVNDASSTTSAGSVRSSAVYRKDGKPLSQEALYRAQQKYGVFQSPARQTGSGLKDSKMASDVAANLANNNRTTIEAYKRVLDSNASRAATAVSSRSRSSSVTSNATVVTTSSKSTNAAVKALSSKPVEQPVAPKKSNMNMSKILVGAEAAAEKRIGIRMKPEKIVYVPSKESGKAAERSMSLTPEIMDKLKTKGDYEAEAEVEADPKKYASKAAFAVRDFDPNEATEKELLEREKKKQAYFGMLTSPQVLSLARANAQVKLDQIDKAAPGSLYKNEEFNKLAVALAQKNSTKRSEHHGKINMGGGLWLTQADVQNIAQGLITPVLDEVDSRALQQRAIDEDIKQRKIDFKEQNAAWIELQRNKLSNDKMYSRETRMRHKRETEGLHARTERKFQDLCASKDSEVAEMEKALQNAKDSYAALQKQMEEDLEKERLRVEAEVAALKKEQEEDLKAARVEQEQELKPYVDDVKAAEAEHERLTAERDSLNKEIEELRASIESHKVRIEELDNEISDSAAKHEEEEGKREELTKHKEEFDQEVSEKFTVIAQAAKEKAQKSSEEARLKQLEVDAMINERQSELNSTELELKKEKLSLLEAMRNVTELKGEDKLDENRVKALIGMTSEEFIAENNKSVNVSDDKFEPFNEHTASTKSIKHEEGVLGEGGAKTNSDELPVKDSAEKSSEHLNSTAEKSIEPAKASSPYPAKPSMVDAVLPKDFKPEVKPKAKPAHKTPQQGAAAGGEPASAKSGVKRSPSLKQKFMGIIKGDTKSQSKPAAAATPVHPPATVKKAAPKKAAASSEADTPAKVSPAKDTAKTEIQKIAQGGPAPAPEPEHKTAPAVDNATTKSVSTLQKPTNSGIDKSEIHKIAQGGPAPTSGHSNHTRTSVYENGDNSDDEDELPDSSEAGENGIGADKKGSLFKEVF
What is the function of this protein?
Required for normal formation of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on plasma membrane and mark the site of endocytosis.
What are the official names of this protein?
Eisosome protein 1.
What is the protein family that this protein belongs to?
Belongs to the EIS1 family.
What are the subcellular locations of this protein?
Cytoplasmic granule. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes at the eisosomes.
Protein: RS17_MARSD
Sequence: MAELNLKGNRRVLTGVVVSDKADKTIVVRCETLVKHSLYKKYIRRHTKFMAHDPSNECGIGDKVQIVEFRPLSRRKRWHLDKILEKAV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PETM_PROMS
Sequence: MAKEIFSIAAVFWILIPIGLVGGALLLKFQGD
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 7, Cytochrome b6-f complex subunit PetM, Cytochrome b6-f complex subunit VII.
What is the protein family that this protein belongs to?
Belongs to the PetM family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: VDAC2_MELGA
Sequence: AIPPSYADLGKSARDIFNKGYGFGLVKLDVKTKSASGVEFTTSGSSNTDTGKVNGSLETKYKWAEYGLTFTEKWNTDNTLGTEIAIEDQIAKGLKLTFDTTFSPNTGKKSGKIKSAYKRECLNLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNFSVGYKTGDFQLHTNVNDGSEFGGSIYQKVSDNLETAVNLAWTAGSNSTRFGIAAKYKLDSTASISAKVNNSSLVGVGYTQTLRPGVKLTLSALIDGKSINAGGHKLGLGLELEA
What is the function of this protein?
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity).  The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity).  The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).  Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity).  Binding of ceramide may be required to trigger the Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity).
What are the official names of this protein?
Voltage-dependent anion-selective channel protein 2, VDAC-2, Outer mitochondrial membrane protein porin 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic mitochondrial porin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane. Membrane. Note=May localize to non-mitochondrial membranes.
Protein: IF2_CAMC1
Sequence: MSNVRISEIANELGYPSKEIVEKAQELGLKVKTHSNAVSLEEAEAIYEYVQTGVIPDKFKKKKSEPKAKKEPKKETEKEPAKKEEKPKTEPKKAATKAEPKPEKAKAEPKKEAQISEEKPKTEPKKEEPVKVEQKPAEAPKPKESLADVTQKRRGLVIVKKKKDYEAPAPIKEEKKAEAAVTNISDFKSMFSASDENLARKKKKEKKVTVVSKKDSAEKMDLLGGSDFGDIVLEDEDVVVLPDFSFKTPAPTPMQRTKQPNAMKTTVNNTINSFGEGGIQRRARKKHKKPENKQNSEAVTSINIPKEIRVYEFAEKLNKQPSEVIGKLFMLGMMTTKNDFLDEDAIEILADEFNVEVNIIDDQKEFDYVAAYEEEIKDDENLQPRAPVITIMGHVDHGKTSLLDYIRKSRVAAGEAGGITQHVGAYMVNKNGRNITFIDTPGHEAFTAMRARGAGVTDIVIIVVAADDGVKPQTKEAVSHAKAAGVPIIIAINKMDKESANPDLVKTGLAELDIMPTEWGGKYEFVPISAKTGMGIDDLLEIVLLQADLLELKANPKANAKATVIESSLQKGRGPVATIIVENGTLHVGDTVVAGVAYGKIRSLLDDQGRSLREIKPGECGVIVGLSEIAEAGETLIGVKTDKEAREYAQKKAEYIRQKELSKSTKVSIDELSAKIAEGELKTLPVIIKADVGGSLEALKASLEKLANDEIRVNVIHSGVGGITQSDVALASASNDCIILGFNIRPTGEIKEKAKESGVEIKTYNVIYNLIDDVKAILGGLMSPIIREEQLGQAQVRQVIHVPKVGTIAGCIVTEGTINRGAKIRLIREGVVVYEGLVSSLKRFKDDVKEVAKGYECGVGIENFNDIRENDYIESFKEVKEKATL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_KINRD
Sequence: MTMTDPIADMLTRLRNANSAYHDTVSMPYSKLKSHIAEILQAEGYITSWTVEDAEVGKKLTLDLKFGPNRERAIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAILSTSSGLLTDKQANKKGVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ATP6_MICAN
Sequence: MLDSLSVLNFYSLASLEVGQHWYWHIGGLKIHGQVIAVSWIVFAILIIASIAATRKIQKVPSGIQNLMEYVLEFLRDLAKNQLGEKEYRPWLPFIGTLFLFIFVSNWLGALIPWKLIELPEGELAAPTNDINTTVALALLTSLAYFYAGISKKGLGYFAHYLEPIPVLLPIKILEDFTKPLSLSFRLFGNILADELVVAVLVFLVPLVVPLPLMALGLFTSAIQALVFATLAGAYIHEALESEHEEEHA
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PKD2_ORYLA
Sequence: MSATRVRPQSQAGTDKPPRTLDSSEGIEMENIQHQDPGLGGVAGSPSPPSRQAWSRDNPVFEPEEEIMQADWPQASPGRRSAFTASGGSSCSSGHGGYTRAGSSTQIPRGGLYPTQTLNGQQQDRHEHPGCMKRIFQNIRILWGTELMEDGDSNRERYLWNVLRELLTYIAFLITICILTYGMISTNMYYYTKAMSQLFLDAPLSSENPKTFRSLSTMEDFWKYTQGPFLGGMYWEVWYNNQSLPGNQSFIYYENILLGVPRLRQVRVHNETCSIHEDLRDEVQGCYGVYTPSNEDNSPFGPQNGTAWVHTTESKMNASTHWGQVSKYGGGGYYQDLSRTREESGLQLQFLKDHLWLDRGTRAIFLDFSVYNGNVNLVCIARLLVEFPATGGVLTSWQFQTLRLIKYVSSWDYFVGVCEVAFCLFVLYYVVEEVLEIHIHRLHYFKNLWNCLDVLIVTLSVVAIIMSITRAAMGGDLLKGLENYTSHTSFDSLANLQVQFNNMAAVIVFFCWVKLFKFINFNKTMSQLSTTMSRCAKDLVGFAIMFFIIFLAYAQLAYLVFGTQVNDFSTFQGSVFTQFRIILGDFDFFEIKEANPVLGPIYFITFVLFIFFILMNMFLAIINDTYSEVKADMAQHRSEMEMTDFIKKGCTKALVKLRLKKTTVDDISDSLRQAGGKLNYDELLQDLKEKGHTEAEIQAIFAKYDQDGDLELTEHDHQQMRDDLEKEREDLDLERNSLTRPSSGRSFPRTQDDSEEDDDEDSGHSSRRRGSSSGGVSYEEFQVLVRRVDRMEHSIGSIVSKIDAVIVKLEGMERAKLKRRDVLVRLLDGVMEDERLGRDADTHREQMERLVKEELERWETDDVASQVSHPQPATPIGPRPRPPSSLSTDGLDTSANGGTHV
What is the function of this protein?
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B.  Can also form a functional, homotetrameric ion channel (By similarity).  Functions as non-selective, voltage-gated cation channel.  Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades (By similarity).  May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By similarity).  Plays a role in fluid-flow mechanosensation: forms a complex with pkd1l1 in cilia to facilitate flow detection in left/right patterning (PubMed:21307098).  Required for normal specification of the body left-right axis during embryogenesis (PubMed:21307098).
What are the official names of this protein?
Polycystin-2, Polycystic kidney disease 2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the polycystin family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cytoplasmic vesicle membrane.
Protein: RSMJ_COXB1
Sequence: MNDTLAITYSTPARLSEAEKLARQMKLPLVSLNSTDYSFLLVFTPAHLELRSTGTKAPGPLYVDFLKGATAHRRLFGGGRSQLIVRAVGLKSHPHPTILDLTAGLGRDAFVLANLGCDVLMIERNPVIALLLRDGLERAQSVEWFKSLKLELIEIDAQIYLSTLKKQFDVIYMDPMYPIRKKSALVKKEMRILRRLVGADDDAPQLLALALKKAKHRVVIKRPRLSNPLPGPAPDVVYEGKSSRFDVYLLKPSS
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: X_HBVG3
Sequence: MAARLCCQLDPSRDVLCLRPVSAESSGRPLPGPFGALSPPSPSAVPADHGAHLSLRGLPVCSFSSAGPCALRFTSARYMETAMNTSHHLPRQLYKWTLGLFVMSTTGVEKYFKDCVFAEWEELGNESRLMTFVLGGCRHKLVCAPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: RS20_CHLPN
Sequence: MAPKKPNKKNVIQRRPSAEKRILTAQKRELINHSFKSKVKTIVKKFEASLKLDDTQATLSNLQSVYSVVDKAVKRGIFKDNKAARIKSKATLKVNARAS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: Y129_JANMA
Sequence: MFEIKTVALFVLTAIAEIVGCYLPYLWLRQGASIWLLVPAALALGIFVWLLSLHPEAAGRVYAAYGGAYVAVALAWLWVVDGIKPTNWDFVGVAVTLAGMGIILFAPRA
What are the official names of this protein?
UPF0060 membrane protein mma_0129.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HLDD_BURPS
Sequence: MTLIVTGAAGFIGANIVKALNERGETRIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVERFARGDFGKVRAVFHEGACSDTMETDGRYMMDNNFRYSRAVLDACLAQGTQFLYASSAAIYGGSSRFVEAREFEAPLNVYGYSKFLFDQVIRRVMPSAKSQIAGFRYFNVYGPRESHKGRMASVAFHNFNQFRAEGKVKLFGEYNGYGPGEQTRDFVSVEDVAKVNLHFFDHPQKSGIFNLGTGRAQPFNDIATTVVNTLRALEGQPALTLAEQVEQGLVEYVPFPDALRGKYQCFTQADQTTLRAAGYDAPFLTVQEGVDRYVRWLFGQL
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: ZNUC_BUCAI
Sequence: MFEFVKLKNVCVNLSHRSILTDISLSLISNRVLTLIGPNGAGKSTLVRIILGLIKPNSGTIIRSNNLSVGYVPQKLHLNTLLPITVERFMKLSRKTNNIKIEEMLKRVKAESLKFCQLQKLSGGEMQRILFAKALLNNPNLLVLDEPTQGVDVMGQLALYKLINEIRHELQCAILIVSHDLNFVMAKTDDVICLNNHICCSGTPETVCNNLEFISIFGLKRVQELAIYHHNHNHIHNF
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DXS1_STRAW
Sequence: MTMLENIRGPRDLKALSEAELGELAEEIREFLVHAVARTGGHLGPNLGVVELSVALHRAFESPVDRILWDTGHQSYVHKLLTGRQDFSKLRSKGGLSGYPSREESEHDVIENSHASTVLGWADGLAKARQVQGEKGHVVAVIGDGALTGGMAWEALNNIAAAKDRPLIIVVNDNERSYSPTIGGLANHLATLRTTDSYEKVLAWGKDVLLRTPVVGNTLYESLHGAKKGFKDAFAPQGMFEDLGLKYVGPIDGHDMKAMESAFRRAKRFHGPVLIHCLTEKGRGYEPALAHDEDRFHTVGVMDPLTCEPLAPSNGPSWTSVFGDEIVRIGEEREDVVAITAAMLHPVGLNKFAEKFPGRVWDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQLLMDVALHRCGVTFVLDRAGVTGVDGASHNGMWDMSILQVVPGLRIAAPRDADQLRAQLREAVAVDDAPTLLRFPKESVGPAIPAVDHVGGMDVLHRFPESPQVLLVAVGVMAPVCLQAAELLEARGIGCTVVDPRWVKPVDPSLPGLAAEHRLVAVVEDNSRAAGVGAAVALALSDAEVDVPVRRFGIPEQFLAHAKRAEVLADIGLTPVEIAGRISAGLATKEELSKEKQE
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase 1, 1-deoxyxylulose-5-phosphate synthase 1, DXP synthase 1, DXPS 1.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.