PharMolix/UniProtQA huggingface dataset:
Protein: KHSE_BACC2
Sequence: MIPLSVRVPASTANVGPGFDSVGIALSLYLDVVVKEKADKWQVIHSFEESIPTDDKNLIVSTACKVCPSISPHIIEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDISVVRIESKELGVISLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMERDHFHEPYRLELVPLLPSIRKCAKEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFTDMKVCELEIDHKGIIVNKEEHIGL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM11_KORVE
Sequence: MEPSLVVVGLNFKTSPVAVRERFWMSELRRYEALHQLVRAEGIDELVVLATCNRTEFILWTSDAGEAADSVLRFLTHEYGLKMSDWSHFYRLMDDVALNHIFRVASSLDSMVIGEPEIVGQFKNAWSQAQAAGTTGRFLDAVMQKALTVSKRVRNETAIGNAAVSIPYTTVELSKQVLGELFDKAVVLMGAGKMSESAAKYLMNHGASQICVINRTLHKAQEFSEKVGGIAVALEDRAPYLDHADIIVSSTSCPHYVIEKADAERIQAARGGKPIVMVDIAVPRDIDPAVREVPGVHLFDMDDLEKVAKRNESERQVAAVAAEEILADEAKGFRRKLMAERVVPTIVALRNRLDEVCRQELESLRQELGPFTEDQDQAMTALTAHITQRIAGSLARELKELPERSEQDMLTMAVQRLFHLEQPQKAAAGTN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase 1, GluTR 1.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PRS7_DICDI
Sequence: MVNKEDVEDELLNETAPVALDEGDIALLKSYGVGPYSKSIRILEEDIKKMTSKVNELCGIKESDTGIGPPSQWDLVVDKTSAHEEPPLQVARCTKIIDVGKPNAKYIITVKQIAKFVVALGDKLSPTDVEEGIRVGVDRNKYQIQIPLPPKIDASVTMMQVEEKPDITYKDVGGCKEQIEKLREVVEMPLLHPEKFVNLGIDPPKGVLMYGPPGTGKTLCARAVANRTDAAFVRVIGSELVQKYVGEGARMVRDLFQMARSKKACIIFFDEVDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALLRPGRLDRKVEFGLPDLEGRAHIFTIHAKTMSCARDIRFELLARLCPNSTGADIRSVCTEAGMFAIRARRKVVSEKDFLEAIDKVIKSYAKFSATSRYMHYN
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
What are the official names of this protein?
26S proteasome regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CSDE1_CAVPO
Sequence: FGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPRPDRLVNRLKNITLDDASAPRLMVLRQPRGPDNSMGFGAERKIRQAGVID
What is the function of this protein?
RNA-binding protein involved in translationally coupled mRNA turnover.  Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.  Required for efficient formation of stress granules.
What are the official names of this protein?
Cold shock domain-containing protein E1, Protein UNR.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P- body.
Protein: OMP41_PORGI
Sequence: MKVKYLMLTLVGAIALNASAQENTVPATGQLPAKNVAFARNKAGSNWFVTLQGGVAAQFLNDNNNKDLMDRLGAIGSLSVGKYHSPFFATRLQINGGQAHTFLGKNGEQEINTNFGAAHFDFMFDVVNYFAPYRENRFFHLIPWVGVGYQHKFIGSEWSKDNVESLTANVGVMMAFRLGKRVDFVIEAQAAHSNLNLSRAYNAKKTPVFEDPAGRYYNGFQGMATAGLNFRLGAVGFNAIEPMDYALINDLNGQINRLRSEVEELSKRPVSCPECPEVTPVTKTENILTEKAVLFRFDSHVVDKDQLINLYDVAQFVKETNEPITVVGYADPTGNTQYNEKLSERRAKAVVDVLTGKYGVPSELISVEWKGDSTQPFSKKAWNRVVIVRSK
What is the function of this protein?
May have porin activity and function in peptidoglycan binding.
What are the official names of this protein?
Outer membrane protein 41, Omp41, PG32.
What is the protein family that this protein belongs to?
Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: METK_SACD2
Sequence: MAQYSLFTSESVSEGHPDKMADQISDAILDAILADDKNARVAVETMVKTGMAIVAGEVRTSTYIDLEDLIRDVILDIGYNSSDVGFDGASCAVLNAIGKQSADIAMGVDEANNKDLGAGDQGLMFGYATNETDVLMPAPIYYSHRLVEKQAELRKNGKLNWLRPDAKSQVTLRYDNGKPVAVDAVVLSTQHNPDVSQATIREAVMEEIIKTTLPAEWLHADTKYHINPTGQFIIGGPVGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLASRCEIQVSYAIGVAEPTSISVNTFGTGSIADSEISKLVAQHFDLRPRGIIEMLDLLRPIYRKTAAYGHFGREEPEFTWEKTDKVAALQG
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_THEM4
Sequence: MWENVKKVDPEIYEVILKEWDRQEYGLELIASENFASLAVIEAMGSVLTNKYAEGYPGRRYYGGCEWVDVAEKLARDRAKELFNVKYANVQPHSGSQANMGAYFAVSEPGDTIMGMSLSHGGHLTHGAPVNFSGRIYNVVSYGVDSETEVINYDEVRELALKHKPKIIIAGGSAYSKIIDFKRFREIADEVGAYLIVDMAHFAGLVAAGIYPNPAEYAHIVTSTTHKTLRGPRGGMILTNDKELYKAINKSIFPGIQGGPLMHVIAAKAVCFKEALTDEFKAYQNQVVKNAKKLAEELEKRGLRIVSGGTDTHLMLVDLNPLNVTGKAAEIALGKCHVTVNKNTIPNETRSPFVASGIRLGTPALTTRGMKESEMEEIAELIVKVLENVKDEEGNVDDSIVEDVQKKVRDLCERFPLYEGKIRL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FH6_ARATH
Sequence: MKALQSRFFFFFFFYIFFSVSVSSEAHRRILHQPLFPESSTPPPPDFQSTPSPPLPDTPDQPFFPENPSTPQQTLFPPPPPPVSADVNGGLPIPTATTQSAKPGKKVAIVISVGIVTLGMLSALAFFLYRHKAKHASDTQKLVTGGGDGGGSRRFQEDSGPPTTTSSTFLYMGTVEPTRVSASESNGGTNGPVNSSPYRKLNSAKRSERYRPSPELQPLPPLAKPPQPSDNSPSALSPSSSSSGEECRDTAFYTPHGSAISSDDGYYTAFPRSANGSLPHSKRTSPRSKFGSAPTTAASRSPEMKHVIIPSIKQKLPPPVQPPPLRGLESDEQELPYSQNKPKFSQPPPPPNRAAFQAITQEKSPVPPPRRSPPPLQTPPPPPPPPPLAPPPPPQKRPRDFQMLRKVTNSEATTNSTTSPSRKQAFKTPSPKTKAVEEVNSVSAGSLEKSGDGDTDPSKPKLKPLHWDKVRASSDRATVWDQLKSSSFQLNEDRMEHLFGCNSGSSAPKEPVRRSVIPLAENENRVLDPKKSQNIAILLRALNVTREEVSEALTDGNPESLGAELLETLVKMAPTKEEEIKLREYSGDVSKLGTAERFLKTILDIPFAFKRVEAMLYRANFDAEVKYLRNSFQTLEEASLELKASRLFLKLLEAVLMTGNRMNVGTNRGDAIAFKLDTLLKLVDIKGVDGKTTLLHFVVQEITRSEGTTTTKDETILHGNNDGFRKQGLQVVAGLSRDLVNVKKSAGMDFDVLSSYVTKLEMGLDKLRSFLKTETTQGRFFDSMKTFLKEAEEEIRKIKGGERKALSMVKEVTEYFHGNAAREEAHPLRIFMVVRDFLGVLDNVCKEVKTMQEMSTSMGSASARSFRISATASLPVLHRYKARQDDTSSDSEHSSNSST
What is the function of this protein?
Might be involved in the organization and polarity of the actin cytoskeleton.
What are the official names of this protein?
Formin-like protein 6, AtFH6, AtFORMIN-6.
What is the protein family that this protein belongs to?
Belongs to the formin-like family. Class-I subfamily.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: E3145_ADE05
Sequence: MTDTLDLEMDGIITEQRLLERRRAAAEQQRMNQELQDMVNLHQCKRGIFCLVKQAKVTYDSNTTGHRLSYKLPTKRQKLVVMVGEKPITITQHSVETEGCIHSPCQGPEDLCTLIKTLCGLKDLIPFN
What is the function of this protein?
Protects virus-infected cells from TNF-induced cytolysis.
What are the official names of this protein?
Early E3 14.5 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E3_15 family.
Protein: GREB_YERPE
Sequence: MAKSNYITREGWQALDRELHYLWREERPVVTQAVSEAAAMGDRSENAEYIYGKKRLREIDRRVRFLAKRLEVLKIVDPDPRQEGKVFFGAWVRVENEQEEQRIFRLVGPDEFDPAKKWISIDSPVARALIGKQVDDEVTVQTPNGEATYWILEIRYRPFDEDRPFNEDIDN
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreB releases sequences of up to 9 nucleotides in length.
What are the official names of this protein?
Transcription elongation factor GreB, Transcript cleavage factor GreB.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family. GreB subfamily.
Protein: VE6_HPV19
Sequence: MANAQATEEEIEIVEEGTTAPQVTEPPLPATIAGLAALLEIPLDDCLVPCNFCGKFLSHLEACEFDDKRLSLIWKGHLVYACCRWCCTATATFEFNEFYEHTVTGREIEFVTGKSVFDIDVRCQNCMRYLDSIEKLDICGRRLPFHKVRDSWKGICRLCKHFYNDW
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: TRMD_ECOSE
Sequence: MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFR_MEDSA
Sequence: MATENKILILGPTGAIGRHIVWASIKAGNPTYALVRKTPGNVNKPKLITAANPETKEELIDNYQSLGVILLEGDINDHETLVKAIKQVDIVICAAGRLLIEDQVKIIKAIKEAGNVKKFFPSEFGLDVDRHEAVEPVRQVFEEKASIRRVIEAEGVPYTYLCCHAFTGYFLRNLAQLDTTDPPRDKVVILGDGNVKGAYVTEADVGTFTIRAANDPNTLNKAVHIRLPENYLTQNEVIALWEKKIGKTLEKTYVSEEQVLKDIQESSFPHNYLLALYHSQQIKGDAVYEIDPAKDIEASEAYPDVTYTTADEYLNQFV
What is the function of this protein?
Reduces achiral isoflavones to chiral isoflavanones during the biosynthesis of chiral pterocarpan phytoalexins.  The reduction product is a third isomer, which represents the penultimate intermediate in the synthesis of the phytoalexin (-)-medicarpin, the major phytoalexin in Alfalfa.
What are the official names of this protein?
Isoflavone reductase, IFR, 2'-hydroxyisoflavone reductase, NADPH:isoflavone oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: SSUD_ECO5E
Sequence: MSLNMFWFLPTHGDGHYLGTEEGSRPVDHGYLQQIAQAADRLGYTGVLIPTGRSCEDAWLVAASMIPVTQRLKFLVALRPSVTSPTVAARQAATLDRLSNGRALFNLVTGSDPQELAGDGVFLDHSERYEASAEFTQVWRRLLLGETVDFNGKHIHVRGAKLLFPPIQQPYPPLYFGGSSDVAQELAAEQVDLYLTWGEPPELVKEKIEQVRAKAAAHGRKIRFGIRLHVIVRETNDEAWQAAERLISHLDDETIAKAQAAFARTDSVGQQRMAALHNGKRDNLEISPNLWAGVGLVRGGAGTALVGDGPTVAARINEYAALGIDSFVLSGYPHLEEAYRVGELLFPHLDVAIPEIPQPQPLNPQGEAVENDFIPRRVAQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: Y288_STRPQ
Sequence: MFQKQERIGLVVYLYYNRDARKLSKFGDLYYHSKRSRYLIIYINKNDLDTKLEEMRRLKCVKDIRPSAFDDIDRQFVGNLHRDETNNHQKG
What are the official names of this protein?
UPF0298 protein SPs1571.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_NITEC
Sequence: MQTKKLNHAPKTGYMFTVTVKNMGITEYLTAWQAMKDFTQQRTRETPDEIWLLEHPPVYTQGIAGKPEHLLFPSNIPVIKTDRGGQITYHGPGQIIMYLLLDLHRWQLGIRQLVRKMEGAVINLMDEYDIVANGSQDAPGVYVNGAKIASLGLKIRRGACYHGIAFNADMDLAPFVAINPCGYPGLRVTQAKELGISDNKEVLAGKLAQNFIAQLTHRIITPHGR
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_BART1
Sequence: MATETERVGAKGGMEHSFGFTRVDETQKQSMVDSVFHSVAENYDKMNDILSLGLHRVWKNSMVAWLSPPALSHWKVLDVAGGTGDIAFRILKASRQKAHATVLDINGSMLSVGKQRAQKNGLAPLIDFVEANAEHLPFEDQSFDAYTIAFGIRNVPHIDQALREAFRVLKPGGRFLCLEFSNVEMPWLDKIYDLWSFHAIPKLGQFIANDGDAYRYLVESIRKFPKQNDFAHMIKQAGFSRVSYRNLTGAIAALHSGWKI
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: METK_BACCQ
Sequence: MTKKRHLFTSESVTEGHPDKICDQISDSILDAILSKDANARVACETTVTTGLVLVAGEITTSTYVDIPKIVRETIQGIGYTRAKYGFDAETCAVLTSIDEQSADIAMGVDQALEAREGQMTDAEIEAIGAGDQGLMFGFACNETQELMPLPISLAHKLARRLTEVRKNDTLSYLRPDGKTQVTVEYDENGKPVRVDTIVISTQHHPDVTWEEIDRDLKEHVIKAVVPAELIDGETKFFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAGLAEKAEVQLAYAIGVAQPVSISVDTFGTGKVSEDVLVELVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDVDLSWERTDKAAALKEQAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y916_CUPNH
Sequence: MAGHSKWANIKHKKAAADAKRGKIWTRLIKEITVAAKLGGGDVDSNPRLRLSIDKAMDANMPKDNIQRAIQRGVGGMEGANYEEIRYEGYGLAGAAIIVDCLTDNRTRTVAEVRHAFSKHGGNMGTEGSVAFMFTHCGQFLYAPGTPEDKLMEAALEAGADDVVTNDDGSIEVTCPPNDFSAVKAALEAAGFKAEVADVVMKPQNEVSFAGDDAAKMQKLLDALENLDDVQEVFTNAVIED
What are the official names of this protein?
Probable transcriptional regulatory protein H16_A0916.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCEA_ECOLI
Sequence: MDQKLLTDFRSELLDSRFGAKAISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT
What is the function of this protein?
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction.  The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions.  The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
What are the official names of this protein?
Glutamate decarboxylase alpha, GAD-alpha.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: PEN2_DICDI
Sequence: MLIPEDDKLDDEKMINIAKKLWFIGFFFLPWVWLINILYFIPYRNSLNDKVKWYLKFSLIGFLGYSTIFMGWMGIYLVNRNKWGAFGDDISITIPFG
What is the function of this protein?
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.  The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
What are the official names of this protein?
Probable gamma-secretase subunit PEN-2.
What is the protein family that this protein belongs to?
Belongs to the PEN-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Protein: DARA_BACSU
Sequence: MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTFMIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLPVDEFHQF
What is the function of this protein?
Binds cyclic di-AMP (c-di-AMP) and is probably involved in c-di-AMP-mediated signaling pathways.  In vitro, can also bind cyclic GMP-AMP (3'3'-cGAMP), with lower affinity, but not c-di-GMP or 2'3'-cGAMP.
What are the official names of this protein?
Cyclic di-AMP receptor A, c-di-AMP receptor A, PII-like signal transduction protein DarA.
Protein: POL2_GFLV
Sequence: MGKFYYSNRRLACWAAGKNPHLGGSVEQWLAAINTDPSFRQTVKEDVQENREQPTAVRMFSWKVGSGPIDNPEKCDWHFVLTGERPAPSRPVKADEVVVVPQPKKVVIPTPPPPPAPYFRAVGAFAPTRSEFVRAIVERLTRLREESRAAALFAELPLEYPQGAPLKLSLAAKFAMLKHTTWRKWYDTSDERLLEAHPGGPCLPPPPPIQNPPSFQERVREFCRMKSCTKAFALETSLGLNKAWVGLVDIPSTSVCCADGKTTGGQTIAQEADPLQHRISTSVAPGRAQWISERRQALRRREQANSFEGLAAQTDMTFEQARNAYLGAADMIEQGLPLLPPLRSAYAPRGLWRGPSTRANYTLDFRLNGIPTGTNTLEILYNPVSEEEMEEYRDRGMSAVVIDALEIAINPFGMPGNPTDLTVVATYGHERDMTRAFIGSASTFLGNGLARAIFFPGLQYSQEEPRRESIIRLYVASTNATVDTDSVLAAISVGTLRQHVGSMHYRTVASTVHQAQVQGTTLRATMMGNTVVVSPEGSLVTGTPEARVEIGGGSSIRMVGPLQWESVEEPGQTFSIRSRSRSVRIDRNVDLPQLEAEPRLSSTVRGLAGRGVIYIPKDCQANRYLGTLNIRDMISDFKGVQYEKWITAGLVMPTFKIVIRLPANAFTGLTWVMSFDAYNRITSRITASADPVYTLSVPHWLIHHKLGTFSCEIDYGELCGHAMWFKSTTFESPRLHFTCLTGNNKELAADWQAVVELYAELEEATSFLGKPTLVFDPGVFNGKFQFLTCPPIFFDLTAVTALRSAGLTLGQVPMVGTTKVYNLNSTLVSCVLGMGGTVRGRVHICAPIFYSIVLWVVSEWNGTTMDWNELFKYPGVYVEEDGSFEVKIRSPYHRTPARLLAGQSQRDMSSLNFYAIAGPIAPSGETAQLPIVVQIDEIVRPDLSLPSFEDDYFVWVDFSEFTLDKEEIEIGSRFFDFTSNTCRVSMGENPFAAMIACHGLHSGVLDLKLQWSLNTEFGKSSGSVTITKLVGDKAMGLDGPSHVFAIQKLEGTTELLVGNFAGANPNTRFSLYSRWMAIKLDQAKSIKVLRVLCKPRPGFSFYGRTSFPV
What is the function of this protein?
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding.  The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier.  Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids.
What are the official names of this protein?
RNA2 polyprotein, P2.
What is the protein family that this protein belongs to?
Belongs to the nepoviruses RNA2 polyprotein family.
What are the subcellular locations of this protein?
Host cell junction, host plasmodesma. Note=Assembles in tubules that are embedded within modified plasmodesmata (By similarity). Movement proteins are targeted preferentially to calreticulin-labeled foci within the youngest cross walls, where they assemble into tubules. During cell division, they colocalize in the cell plate with KNOLLE, a cytokinesis-specific syntaxin. SUBCELLULAR LOCATION: [Protein 2A]: Host cytoplasm. Host nucleus. Note=Cytoplasmic early in infection. Later in infection, it becomes progressively concentrated around the nucleus, where it forms large aggregates. SUBCELLULAR LOCATION: [Coat protein]: Virion.
Protein: PANB_MYCMM
Sequence: MSEQISEQSEQNVYGASSPVPAGESSPSAASAPRTKVRTHHLQKWKAEGHKWAMLTVYDYSTARAFDDAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYESGPSAALAAATRFMKEAGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPSCDGQVLVWQDMAGLSSGKAPRFVKRYADVGGELRRAAVQYAQDVAGGVFPAEEHCF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_PARMW
Sequence: MAKFDAHLKCSFCGKSQDQVRKLIAGPGVYICDECIDLCNEILDEELVDSQGNRGQAADSSRKAAPAAKKSGKPAPTLASIPKPQQIKSFLDEQVVGQEAAKKVMSVAVYNHYKRLAWQGDGQGETEQTATRLHKSNILLIGPTGCGKTLLAQTLAEMLDVPFAVADATTLTEAGYVGEDVENILLRLLQKADMDVDQAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGTVANVPPQGGRKHPYQDCIQIDTSQILFICGGAFVGLDEVVQKRMGRNAIGFMPTDGRGRSRANRELQTTQVLRHLEPDDLVKYGLIPEFIGRMPVSAVLEPLDESALESILTEPRDALVKQFRTLLSMDNVQLQFEPAAIHAIAQEAHRRKTGARALRGIVEELMLDLMYDLPSQSTVKEFTITQAMVEQHTGGKVLPLPGTEQQKTA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: HJA3_METJA
Sequence: MAELPVAPCVRILKKAGAQRVSEAAGKYFAEALEEIALEIARKSVDLAKHAKRKTVKVEDVKAALRG
What is the function of this protein?
Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils.  Increases the resistance of DNA to thermal denaturation (in vitro).
What are the official names of this protein?
Probable archaeal histone 3.
What is the protein family that this protein belongs to?
Belongs to the archaeal histone HMF family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: FSLE_DICDI
Sequence: MEMIRIFLIYLILKIIIINGENNEYSKGYGVGIVFPGSKCLNYVGDSIGQPLCNNRLFNGGKKIYSTVTLVDNKNISSQELSKIEILKSFEALTFLQDQCDDLLFTQFGLCDLNFSPCVETIPKITPLQNVSLPQRLCKSVCERMVSNCPRLSLKIDCSISFLFPEIGTEYNLTLYGYTENKGLYKVPCIDPTDGYNNISNQMELIQACPYPLLLKNSSDPKYSPNKGYTYLPPTNCVLTCPMPNYTKTQWKRVYDMAKTLSSISFICACYNILTFGILNRKRKSKYNICITLMSTSIALVYLTDIIKFGYGIEEFLCPEPGRSAVQNDAACGITGAMFHFGITYCCCWAMTMSIVLFCSVKRIKLFYFRHFMIGNTIFTIITTVILLSAKKMVAGTGYIECWVRERWFVITLFWLPCGIGLSIGIFCIGGVIHEIYNISKKVNIRESEFILRQIKPFSLVFSVAGSFLYLFIFFFDVERKIDSYKAAVADYVLCLLSGGSEETCFTTGPNYASFFIFYFFIRVFGVLFFSIYGTSRVARDIWSEVVFDEVRSRLSQSESGISRNNSRTDISFGKNNNSKNSNNSKNSNNSKNSNNSDNDSKSIELEKK
What are the official names of this protein?
Frizzled and smoothened-like protein E.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.