PharMolix/UniProtQA huggingface dataset:
Protein: VPU_HV1B9
Sequence: MLSLQILAIVALVVAAIIAIVVWSIVFIEYRKILRQRKIDRLIDRIREREEDSGNESEGDQEELAALERGHLAPWDVDDL
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: LNT_NEIMB
Sequence: MVSKLDKYWQHPALYWPLLILFAAATPFTFAPYYHFWLMPLIFGAFVRLIELRPRFAVSSAYLFGLTAYTTQFYWIHTALHDVSGLPDLYAVPLTFLLPAYLALYPALCFWLWKKFTLPRGIKIGLVLPILWTLTEFARERFLTGFGWGAIGYSQITPDSPLAGFAPLGGIHMVTLATAFLGVWLVLASNNTARSGKRLLPIILIAALLAAGYTARQTDFTRPDGSRSTVALLQGNIDQTLKWREDQVIPTIQKYYEQVGKTTADIVILPETAIPVMRQNLPENILAKFAEQAQNNGSALAVGISQYTSDGNGYENAVINLTGYQENNQDGIPYYAKNHLVPFGEYKPLPFLTTPLYKMMDMPLSDFRKGGGKQSALLMKNQKIAFNICYEDGFGDELIAAAKDATLLANASNMAWYGKSNAMYQHLQQSQARAMELGRYMVRATNTGATAIISPKGNIIAQAQPDTETVLEGHIKGYVGETPYMKTGSSWWLMGILALAALILFIFRNKEH
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIP29_ARATH
Sequence: MEVPMDCPGCENKVRKALEKMNGVHDVQIDIKQQRVTVTGSAEQKKVLKVARNVTKRDICLWSYPYHPESNGYNDRYFKKKFRKRINMSVNGEKVSSYNYHKHGYHGHEHGYYQERPYSGLINPSASSMFSEENPHFCSIM
What is the function of this protein?
Heavy-metal-binding protein.
What are the official names of this protein?
Heavy metal-associated isoprenylated plant protein 29, AtHIP29.
What is the protein family that this protein belongs to?
Belongs to the HIPP family.
Protein: VPS9A_ARATH
Sequence: MENTDVFLGLHDFLERMRKPSAGDFVKSIKSFIVSFSNNAPDPEKDCAMVQEFFSKMEAAFRAHPLWSGCSEEELDSAGDGLEKYVMTKLFTRVFASNTEEVIADEKLFQKMSLVQQFISPENLDIQPTFQNESSWLLAQKELQKINMYKAPRDKLVCILNCCKVINNLLLNASIASNENAPGADEFLPVLIYVTIKANPPQLHSNLLYIQRYRRESKLVGEAAYFFTNILSAESFISNIDAKSISLDEAEFEKNMESARARISGLDSQTYQTGHGSAPPPRDESTLQKTQSLNPKRENTLFQSKSSDSLSGTNELLNINSETPMKKAESISDLENKGATLLKDTEPSKVFQEYPYIFASAGDLRIGDVEGLLNSYKQLVFKYVCLTKGLGDGTSLAPSSSPLQASSGFNTSKESEDHRRSSSDVQMTKETDRSVDDLIRALHGEGEDVNNLSDVKHEEYGAMLVEGKDEERDSKVQGEVDAKDIELMKQIPKREGDNSSSRPAEDEDVGSKQPVTEASE
What is the function of this protein?
Functions as guanine nucleotide exchange factor (GEF) for Rab small GTPases.  Activates specifically RABF1, RABF2A and RABF2B proteins.  Required for early stages of embryogenesis, cytokinesis, embryogenesis, and organ development.  Is essential for the establishment or maintenance of the polar localization of the auxin efflux carrier PIN1.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 9A, AtVPS9a.
Protein: RT21_HUMAN
Sequence: MAKHLKFIARTVMVQEGNVESAYRTLNRILTMDGLIEDIKHRRYYEKPCCRRQRESYERCRRIYNMEMARKINFLMRKNRADPWQGC
What are the official names of this protein?
28S ribosomal protein S21, mitochondrial, MRP-S21, S21mt, Mitochondrial small ribosomal subunit protein bS21m.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL9_NITOC
Sequence: MEVILLEQVVNLGKLGDKVAVKSGYARNYLIPQGRAVSATKENEAHFESRKAELEKAAGDKVAVAERCKQALADLGSVTIPAKAGTEGKLFGSVGAADIAEALTKAGVEIGKKEVRLPEGALRQVGEYELVIHLHPTVEAPIKVVVTGEEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: AVR2A_BOVIN
Sequence: MGAAAKLAFAVFLISCSSGAILGRSETQECIFYNANWERDRTNRTGVESCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNERFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
What is the function of this protein?
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.  Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.  Receptor for activin A, activin B and inhibin A.  Mediates induction of adipogenesis by GDF6.
What are the official names of this protein?
Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: STING_CHICK
Sequence: MPQDPSTRSSPARLLIPEPRAGRARHAACVLLAVCFVVLFLSGEPLAPIIRSVCTQLAALQLGVLLKGCCCLAEEIFHLHSRHHGSLWQVLCSCFPPRWYLALLLVGGSAYLDPPEDNGHSPRLALTLSCLCQLLVLALGLQKLSAVEVSELTESSKKNVAHGLAWSYYIGYLKVVLPRLKECMEELSRTNPMLRAHRDTWKLHILVPLGCDIWDDLEKADSNIQYLADLPETILTRAGIKRRVYKHSLYVIRDKDNKLRPCVLEFASPLQTLCAMSQDDCAAFSREQRLEQARLFYRSLRDILGSSKECAGLYRLIAYEEPAEPESHFLSGLILWHLQQQQREEYMVQEELPLGTSSVELSLQVSSSDLPQPLRSDCP
What is the function of this protein?
Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (By similarity).  Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (By similarity).  Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:30842659).  Upon binding of c-di-GMP or cGAMP, STING1 oligomerizes and is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state (PubMed:30842659).  In addition to promote the production of type I interferons, plays a direct role in autophagy (By similarity).  Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (By similarity).  The ERGIC serves as the membrane source for LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (By similarity).  The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (By similarity).  Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (By similarity).
What are the official names of this protein?
Stimulator of interferon genes protein, STING, Transmembrane protein 173.
What is the protein family that this protein belongs to?
Belongs to the STING family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=In response to double-stranded DNA stimulation, translocates from the endoplasmic reticulum through the endoplasmic reticulum-Golgi intermediate compartment and Golgi to post-Golgi vesicles, where the kinase TBK1 is recruited. Upon cGAMP-binding, translocates to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) in a process that is dependent on COPII vesicles; STING1-containing ERGIC serves as a membrane source for LC3 lipidation, which is a key step in autophagosome biogenesis.
Protein: ACYP_MYCSK
Sequence: MSAEPEVRLTAWVHGRVQGVGFRWWTRSRALELGLTGFAANKPDGRVQVVAQGSREDCERLLGLLEGGDTPGRVDKVIADWSDAREQITGFHER
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: RL27_NEIMF
Sequence: MASKKAGGSTRNGRDSEAKRLGVKAYGNELIPAGSIIVRQRGTKFHAGDNVGMGKDHTLFAKVDGYVEFKTKGALNRKTVSIRPYTGSEE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: MP3K2_ARATH
Sequence: MKKSSDKSPVRQHDTATQINSDAVSSSTSFTDSDSTCSFLTPSMEFPDRISFRRIDFSEAAPTGVVLPSTSSELTRSNSSENKIPNEDISVSTSSRYLVFDKILALMKKSPGRRGDKTSPARRLDRSDAVRRNIDYDAGEDSSSLLITRSLDFPNRTSFRVDGVDDGEIDRIYQYIGVSGPEDFAISSDAWKARMEHERSSSDVVNKLKSLDLDSREAGPSGGVVASSSMNHKFQGHDLSEAGSIGVVVASNFTLSESNKIENLNSLRDKEIVDGDMVENRCGIERKPTILVKSRGYLVHNDDVGVGGGIKGVRPPVLNVPRADKEVVDGGTVESKSGIEWKPTILVKSKGYLVSNDGGIKGVTSPVLNLRPTDKEVVDSGTVENRRGIKGVRPSVLKPPPVMKLPPVDLPGSSWDILTHFAPDSEIVRRPSSSSSSENGCDEEEAEDDKVEKEETGDMFIQLEDTTDEACSFTTNEGDSSSTVSNTSPICVSGGSINTSWQKGQLLRQGSFGSVYEAISEDGDFFAVKEVSLLDQGSQAQECIQQLEGEIALLSQLEHQNILRYRGTDKDGSNLYIFLELVTQGSLLELYRRYQIRDSLISLYTKQILDGLKYLHHKGFIHRDIKCATILVDANGTVKLADFGLAKVSKLNDIKSRKETLFWMAPEVINRKDNDGYRSPADIWSLGCTVLEMCTGQIPYSDLEPVEALFRIRRGTLPEVPDTLSLDARHFILKCLKLNPEERPTATELLNHPFVRRPLPSSGSGSTSPLIRR
What is the function of this protein?
Triggers SUMM2-mediated immune responses, including cell death and defense responses.  Probably inhibited by the MEKK1-MKK1/ MKK2-MPK4 kinase cascade to adjust plant defense (PubMed:22643122, PubMed:23695980).  Seems to contribute in transducing external glutamate (L-Glu) signal that elicits large-scale changes in root architecture (PubMed:23574009).
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 9, MAP kinase kinase kinase 9, MAPK/ERK kinase kinase 2, AtMEKK2, Protein SUPPRESSOR OF MKK1 MKK2 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Protein: U195_CAEEL
Sequence: MGQERLDNANPTLFDSKPRHRPVTGTERDESVEDPIDSWEIFDLIRDINDPEHPYTLEQLNVVQEELIKVFIDEEETFVKVNFTPTIPHCSMATLIGLAIRVKLLRSLHPKVKVSVSITPGSHSTEESINRQLADKERVAAAMENQGLMHAVNECLRVPE
What is the function of this protein?
May play a role in chromosome segregation through establishment of sister chromatid cohesion.
What are the official names of this protein?
MIP18 family protein F45G2.10.
What is the protein family that this protein belongs to?
Belongs to the MIP18 family.
Protein: YA047_YEAST
Sequence: MRSESEVSISTVFLGEYVGDDEKSLGILMGGSTSCMVGMNSAFVNDTIRLDLPTPSSPQITTRIVSLVIVLFNTLVFRSPLFLFSIFICLIYKFHSCFEGKPLYQMLKI
What are the official names of this protein?
Putative uncharacterized membrane protein YAL047W-A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYDND_THEP3
Sequence: MGEQLNGLKRTHMCGELTVEDVDKSVVVMGWVQRRRDHGGLVFIDLRDRTGIVQVVFSNEVSSEAFEKVQSVRSEYVLAIEGKVVKRAPENVNPKISTGEIEIYANTLKILSKSETPPFPIEDRSNVSEAIRLKYRYLDLRRPSMQQNLMTRFKITKVVRDFLNRNGFIEIETPLLIKSTPEGARDYLVPSRIYPGKFYALPQSPQIFKQLLMISGFDKYYQIAKCLRDEDLRADRQPEFTQIDIEMSFVEVEDVLKINEKMIAEIFKETLGIDVPIPFKRLSYQESMERFGTDKPDLRFGMELKDLSDIVAQSEFNVFKTALKNNGSVRGINVKGAASMPRRQLDELVEFAKTYGAKGLLWIQVFEKEVKSPATKFLSEEEMKKILERLEAEAGDLLLIVADKDEIVFDTLAHLRLELGKRFNLIDENKYEFVWIVDFPLLEYDEGEKRYVAKHHPFTAPKDEDIELLEKEPLKVRAKAYDIVLNGTEIGGGSIRIHDTELQKRMFKVLGFSEEKAWERFGFLMEAFKYGAPPHGGIAYGLDRLAMIITGSDTIRDVIAFPKTQNAVCLMTDAPSEVSEEQLKELHIKVDL
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRP36_MOUSE
Sequence: MRKAGSRARAEAEGPHRAMEGGEVTGDRLKADTPDVSFEELLRLQGQGRPKAHKQLVAGNSTRTRSPQQPVCVADKHRPLEMSAKVRVPFLRQVVPISKKVARDPRFDDLSGDYNPEVFDKTYQFLNDIRAKEKQLVKKQLKRHRSGEERDKLQQLLQRMEQQEMAQQERKQQQELRLALKQERRAQAQQGHRPYFLKKSEQRQLALAEKFKELRRSKKLESFLSRKRRRNAGKDRRHLPLSKE
What is the function of this protein?
Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.
What are the official names of this protein?
Ribosomal RNA processing protein 36 homolog.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GMHA_DESVH
Sequence: MTEEARRIVIEHAVEGTRLRESYFNGNADKVVDGARRMAVTLAKGHKLLFCGNGGSAADAQHLAAEFVNRFQMERPPLPAIALTTDTSIITAIGNDYSFDQIFEKQVQALGNEGDMLVGISTSGNSPNVVRAMHAARERGLATMGLTGRGGGEMAGLCDILFDVDHGRTALVQEVHITIGHLLCGLTDHFLFENVLALQPWLKDATNA
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBT_OLTVI
Sequence: MEALVYTFLLVGTLGIIFFAIFFREPPRIVK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y703_METJA
Sequence: MKIIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLNFIMGNGDNFDIIKEIDFINKIVDIGVKSREDLETIKKVLNKDDRAIVATETLKDIELLKEKDIVVSLDFKNGNLLNYSLDEILSCVRDDTPLIILDISSVGTQRGVNAELIKYVLDKTNNPVYVGGGIKGMEDLELCYNLGVDAVLIATAIHKGVLDLEEIINKFGD
What are the official names of this protein?
Uncharacterized protein MJ0703.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
Protein: ISPG_GEOSL
Sequence: MKAKTRQIRVGNVPVGGDAPCSVQSMCNTDTRDAGATLDQINALAAAGCEIVRCAVPDMAAAEALGAIKRQSPIPVIADIHFDYKLALKVLEGGIDGLRLNPGNIGERWKVEEVVAAARERLVPIRIGVNAGSLEKELLQKYGHPTAEAMVESALGHVRILEELGYDQIKISLKASDVPKTVAAYRLLAQRIDYPLHIGITEAGTMFSGTIKSAVGLGILLADGIGDTLRVSLTGDPVDEVRVGFEILKALNLRQKGINLVSCPTCGRCQINLIGVAEEVEKRLAGIDAHLTVAVMGCVVNGPGEAREADVGIAGGRGEGLLFRNGEIVRKVPEADMADALIAEVEKILAEKH
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: F16PA_HELPY
Sequence: MDYKCFKGKHANIVIEIISLLEKGVKKAQEILEKPDAGSYTKLENSSGDTPIKADLALDKFLEENFLSLENIKSVFSEEKETPVTKENGSYLIAYDPLDGSSVMEANFLVGTIIGIYEKDYKAQNLAASLYVVFGHKIELVVALEEVYRYSFYQNKFHFIETIVLENKGKIVASGGNQKDFSLGLKKALEGFFAENYRLRYSGSMVADVHHVLVKKGGMFSYPQKKLRKLFEVFPLALMVEKAKGEAFYFDKGVKKRLLEQSVENYHEKSECYLASQHEAHILEKYLKGE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POTA_BACFR
Sequence: MNMQESKSIIEVNGVSKFFGEKTALDHVTLNVKKGEFVTILGPSGCGKTTLLRLIAGFQTASEGEIKISGKEITQTPPHKRPVNTVFQKYALFPHLNVYDNIAFGLKLKKMPKQTIEKKVKAALKMVGMTDYEYRDVDSLSGGQQQRVAIARAIVNEPEVLLLDEPLAALDLKMRKDMQMELKEMHKSLGITFVYVTHDQEEALTLSDTIVVMSEGRIQQIGTPIDIYNEPINSFVADFIGESNILNGVMIHDKLVRFCNTEFECVDEGFGENMPVDVVIRPEDLYIFPVSEAAQLTGVVQSSVFKGVHYEMTVLCNGYEFLVQDYHHFEVGALVGLLVKPFDIHIMKKERVCNTFEGKLIDETHVEFLGCNFECAPVTGIEAGSEVKVEVGFDNVILQDNEEDGALTGEVKFILYKGDHYHLTVLSDWDENVFVDTNDVWDDGDRVGITIPPDGIRVIKN
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ALDH4_BACSU
Sequence: MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPATGETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELAQLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGVVGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVINIIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILLPDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLHKDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMTIAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVWVNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED
What are the official names of this protein?
Putative aldehyde dehydrogenase DhaS.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: UBE2S_DROPE
Sequence: MSSQYSNVENLSPQTIRQVMRELQEMETTPPEGIKVLINESDVTDIQALIDGPAGTPYAVGIFRVKLTLSKDFPQTPPKAYFLTKIFHPNVAGNGEICVNTLKKDWKPDLGIKHILLTIKCLLIVPNPESALNEEAGKMLLERYDDYSQRARMMTEIHAQPAKCGVGAASDAKDDDGPSTKKHAGLDKKLQDKKKEKLLKEKKRMLKRL
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis.  Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 S, E2 ubiquitin-conjugating enzyme S, Ubiquitin carrier protein S, Ubiquitin-protein ligase S.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: RLMI_ALIFM
Sequence: MTVSIYLAKGRDKALRRRHPWIFSRGIDRIDGKAELGETVEIYANNGEWLARGAFSPQSQIRARVWTFDKNEAIDKDFFVRKLNQAQALRDVLAERDGLTGYRLIAAESDGLPGITIDRYQDYFVCQLLSAGAEATKDLLVEALVECYPDCNIYERSDVSVRKKEGLKQRTGVLHGEEPPESVVIEENGVKISVDIVNGHKTGFYLDQRDSRERACKYVKDKSVLNCFSYTGGFGLYALKGGAKHVINADVSQLALDTAKYNAEINKFDLSKAEFLNADVFKLLREYRDNGTKFDVVIMDPPKFAESKNQLTGACRGYKDINMLAMQILNPGGTLLTYSCSGLMDAGLFQKIVADAALDAHRTVQFIERFEQAADHPLDSAYPEGFYLKGFACRVV
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAC_BUCAP
Sequence: MTFYNEFFKRLQRLMPSNVKPKFESDQDLLAWNQEQGRLSSESILRENKAMKMQRVLGRSGIRELYMNCSFENYKIEHDGQRKVLKAAKRYAEEFNENIASFIFSGRPGTGKNHLASAIGNYLILHGKSILIVTVADLMSNMKGTFSGTSNITEENLLHNLSSVDLLMIDEIGMQTESRYEKVIINQIVDRRSSSKRSTGMLSNLDHRGMKNLLGERVIDRMRLGNSLWLTFEWDSYRQYVRGDEY
What is the function of this protein?
This protein is required for chromosomal replication.  It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity).
What are the official names of this protein?
DNA replication protein DnaC.
What is the protein family that this protein belongs to?
Belongs to the DnaC family.
Protein: TRUB_CHLL3
Sequence: MEAEHTSTKGVPEAGEFLLLDKPLDWTSFDVVAKIRNTYKRGGLKRKVGHSGTLDPKATGLLILATGRKTKEIASLEGLDKEYLAVIKLGARTASHDVETPETDHTPAGHITLAMVRAAALAFVGPRLQQPPMHSASWHEGKRLYALARKGEEVKERKAKEIVIHQFEVTHMQGPLVYCRLLVSKGSYIRVIADELGMALGVGAYLAGLRRTAVGPYRVEDAMSVEDARARILSQIAVDEQQPGGVLAQHEREGSRALDSAAGNAEHDREEARIADNNREDRSRQHADR
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: PHNX_VIBPA
Sequence: MSNSPIQAVIFDWAGTIVDFGSFAPTSIFVEAFKQGFDFDIDLEEAREPMGLGKWDHIQAVGRIPAVDKRWNEKFGRSMTNEDIDAIYAAFMPLQKAKVADHAEPILNAVEVVNGLKDKGIKIGSCSGYPREVMDVLIPVAADYGYQPDYVVATDDLPQGGRPAPFMALKNVIELDVTDVKACVKVDDSAPGIFEGHNAGMWTVGLLLSGNEAGLTFEEYQAADEATLEKAREKARAKFIKSAPHYLIDTISDLPEVIVDIEQRLAAGERP
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
Phosphonoacetaldehyde hydrolase, Phosphonatase, Phosphonoacetaldehyde phosphonohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PhnX family.
Protein: ATP6_PECAS
Sequence: MAAGEISTPQEYISHHLHHLQVGTGFWSINVDSMFFSIALGILFLVIFHRVAKRATSGVPGKLQTAVELLIGFVDGTVRDMFHGKSKLIAPLALTIFVWVFLMNMMDLLPIDLLPQLWAGVYSLLGYDPAHAYLRAVPTADVNITLSMALGVFILVLFYSIKMKGLGGFVKELTMQPFNHPVFIPINLILEGVSLLSKPISLGLRLFGNMYAGELIFILIAGLLPWWSQWLLNVPWAIFHILIITLQAFIFMVLTVVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.