PharMolix/UniProtQA huggingface dataset:
Protein: YR449_MIMIV
Sequence: MSNMSKGNLKTDKNTDYLFRYFMNEDKLNEQLRTELDREMDEKIKANKNFRLDTRIGTERNKSVTKKPNINGGNVNNANGANNNSSEETELPSNSENSDKPNVDFNDSDSDSSNQDSVTASDGFNGSKSPYKNKINAVPGSILPVNTFGQFPGLNQNFQQDSGQNFNQSPVARNTYTAPQPALGDRLIGDIEKYIETPEEKRARAREAYAKLEELVENYSVQLSRTYTIDDDPNELEAEYQMQKDKRSKKTQVQFYKQILLNIVCGAEYLNETYDPFKIKLKDWSKQMASDMDNYTEVLGEIYEKYRDRGGKMAPEIKLLFMIIMSGVTFHLSQKLFGQGGLSDVVGNNPNVINQLLGGLMKGGMGNMLGGDEPVEAKVTPKNNKSILEAIKKYNNKGTSESKSESRSDYKSESVNSVSTEKSDKQSETIKKITEANEIVAKERERRLMAEQRAEMEAQLRRQSEQHAAEMEQMRNQYLNSIGQLSTTRPVDNYSQPSINDNYVNTPTKINNSVNLVLSDATKKPRFLNNQKVANSPIISNKPLNTRDIGFGDFFGNETDMNKESSKKSGRLNIGGFDNLDSLDSTNSIDSEDDDIVSDINDFFASNKPTKSPKQPVSATKSTTKKRPNSITRSATRSVGRKKGTETSDLITPRKPKIIDL
What are the official names of this protein?
Uncharacterized protein R449.
Protein: VP59_LYCMC
Sequence: MNSREMFCVFILFASFFYCSYAEQECNCDKSCEPVKDCTFGTAMDKCGCCEVCAVGIGHFCGKFFNNAVCAEGLKCAKLGEGADGEALEICLRA
What are the official names of this protein?
Venom protein 59.1.
What are the subcellular locations of this protein?
Secreted.
Protein: GAL4_ASPNC
Sequence: MEDASGSYPFGVATADGTPLQIDAENAAVRGINEWSWGSMSPGIPPAAFRPYSLPQFMDRPGPYPYQSSSSSSRELSGSAAKVAIPRTTSASSQSQRRRSARACEPCRQRKIKCDGSKPVCRQCIDHNVSCFFVDVKRVRDQKQLGLLGKKVEQYERLLQELEKEVDENAARRIRKVLRGTDISSPTDDGGDSDSSISSIGSLEALDLVEEDLNRSEKTVATGFFGKNSEVAWMQKLEDEAKSRNRKKEDSTDMEDGVAGGHTMTPPQKQETAMAAMSYYLDDIGIPLMDSVDPYALPPKDLANRFFTAFMDSVHPSFNVVRKTAFVSQYRQFFSQPAQPPQRWLAILNMIFAIGCRYTQATSGRPDSGDYNDLVYLNRARKLTLSENVIFEHADLQQIQVEFLVALYFVSKCQINRAFKFSSMAFRSAVSLGINLRFVDDRTQYPAKEARIRLWWSIFLLEHLLTAITGRVSCVGESLSATPLPIPYEEEAFGRPDVLPLLQDSSLRMTRLKLTLLQSDEESRADVSWLPSCEPSPSLYFHCIVDLATITQAIINKVYSIQGLRERASQVEQRIRRFSFNLDMWLSKVPEAYRFTSGSGDQLDLPSDRNAPWMRERISLAMSYYSSRLTLCRPCLTHTGLAPGDPSPDPAVPPSARQGSRRISSSRMQFNTAMALTCVRSARSLLCCIPETPDITWLTTMTPWWCILHYIMQATTTILLHLSSWPTRLPNDPMHQVSADIEATSRETKKALRWLHHMAYKYPAARRAFRQCNSIVRRITPSLGIDISDIPSGKDLPTEDDAYHLRDIDNTPSSRAGSMEFERHH
What is the function of this protein?
Transcription factor that negatively regulates the biosynthesis of ochratoxin A (OTA), a mycotoxin composed of a chlorinated type I polyketide dihydroisocoumarin moiety linked to L-phenylalanine, and demonstrated to have nephrotoxic, immunotoxic, genotoxic, neurotoxic, and teratogenic properties (PubMed:36006213).  Regultes also cellular redox homeostasis and sensitivity to H(2)O(2) (PubMed:36006213).  Carbon sources such as sucrose, glucose and arabinose repress gal4, leading to up-regulation of OTA biosynthetic genes and altered cellular redox homeostasis (PubMed:36006213).
What are the official names of this protein?
Transcription regulator galc.
Protein: SIX3E_LEIHE
Sequence: MKLLLLLTISASMLIEGLVNADGYIRGGDGCKVSCVINHVFCDNECKAAGGSYGYCWAWGLACWCEGLPADREWDYETDTCGGKK
What is the function of this protein?
Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis.  They bind voltage-independently at site-4 of sodium channels (Nav) and block action potentials, primarily by depolarizing the axonal membrane and suppressing the sodium current.  This depressant toxin is active only on insects.  It is found in a relatively small amount in the venom.
What are the official names of this protein?
Beta-insect depressant toxin Lqh-dprIT3e.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HEMH_SCHPO
Sequence: MIRFCPSCFALKRTAPVLNHTSRLGNYFNNTFSKFSVNRMSVSSYSSDASSTVMDESPPNGVTKSVSGKGPTAVVMMNMGGPSNLDEVGPFLERLFTDGDIIPLGYFQNSLGKFIAKRRTPKVQNHYSDIGGGSPILHWTRIQGSEMCKILDKKCPESAPHLPFVAFRYAPPLTEDMLDELKKANVSRAVAFSQYPQWSCATSGASLNELRRKLIEKGMEKDFEWSIVDRWPLQQGLINAFAENIEETLKTYPEDVRDDVVIVFSAHSLPMSQVAKGDPYVYEIAATSQAVMKRLNYKNKFVNAWQSKVGPLPWMSPATDFVIEQLGNRGQKNMILVPIAFTSDHIETLKELEDYIEDAKQKGITGVKRVSSINGSMTAIQGMADLVAEHLKAKVPYSRQFTQRCPGCTSESCAERINFFQDF
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, mitochondrial, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Cytoplasm. Nucleus. Note=Bound to the mitochondrial inner membrane in eukaryotic cells with its active site on the matrix side of the membrane.
Protein: RSMH_PSEE4
Sequence: MTIDSGFNHITVLLDEAVEALALRADGCYLDGTFGRGGHSRLILSKLGPQGRLLGFDKDPQAIATGQALAAEDGRFVIVQRSFAELGAEVAGRDLAGKVSGILLDLGVSSPQLDDPERGFSFLNDGPLDMRMNPNQGISAAEFIATAPVEEIARVFKEYGEERFAGRMARAVVERREKQPFTRTADLAEVLKVANPAWEKGKNPATRAFQGLRIHVNNELGDLETGLEAALDALEVGGRLAVISFHSLEDRIVKLFMRKLVKGEADNLPRNLPVQHKTFEPRIKLIGKAQFASEAELKANPRSRSAVMRVAEKLR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_BRUSI
Sequence: MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVKPQTFMNLSGQSIGEAMRFYKLTPADLVVIYDELDLVPGKLRIKTGGGPGGHNGIKSIDAHMQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNEWLDTLMGAVADNVAMLARREDNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAEMLKKLLGKKD
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAG2_CAEEL
Sequence: MIAYFLLLLTCLPVLQARVEVHQEFISSKRVSVRFEIVTESHSPNRPVTFDLFPRGPKTNIILLDTFNPVFNFSIQLVQPFTGQPLGDRIYRKVQFSGTNQPWINDTFTTTSGISLSVATEVTCARNYFGNRCENFCDAHLAKAARKRCDAMGRLRCDIGWMGPHCGQAVDPRKCSCENDGICVSSMIHPSQPNQTSSNEQLICECTNGFTGTRCEIFGFNQFQLTAPRPDACSVKDACLNGAKCFPNGPKVFCSCAVGFIGEFCEISLTTTTPTTVEITVSTSGYSSAVYITVALFVIFSIIIGCFKYKFKPMRQQALARGQVPEPYKMPETKSMLIDPEASEAQKKVFTIEGSVQKIDEEVRYTSAPRKYESNNEYAVIQKSTPPPPSLSPPSIPACHYV
What is the function of this protein?
Probable ligand for lin-12/Notch and glp-1/Notch receptors and involved in the mediation of Notch signaling (PubMed:8139658, PubMed:7607081, PubMed:18036582, PubMed:18700817, PubMed:8575327).  Involved in the lin-12/Notch pathway signaling of cell fate in vulval precursor cells (VPCs) and in the postembryonic mesodermal lineage (M lineage), acting redundantly with dsl-1 and apx-1 (PubMed:14960273, PubMed:18036582).  Functions in uterine cells to promote basement membrane mobility during tissue remodeling (PubMed:27661254, PubMed:8139658).  Required for oocyte growth control, acting redundantly with apx-1, perhaps signaling via the glp-1/Notch pathway (PubMed:19502484).  Plays a role in Notch-dependent induction of left-right asymmetry in interneurons and motoneurons (PubMed:21737278).  Involved in maintaining the developmentally arrested larval state known as dauer, probably signaling in the glp-1/Notch pathway (PubMed:18599512).  Required for normal sleep bout quantity and arousal thresholds during the transition from the last larval stage to adulthood in well-fed animals (PubMed:29523076).
What are the official names of this protein?
Protein lag-2, Lethal protein 461.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: TOXN_BACTK
Sequence: MTNKDNPKFHTISTEYIDYLREADSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTSRNDKNFNSQVSVKLFDNDEKRIGVLLVNNMIPVPEKECKEIDIAEKTAADPQYGNLMLKQYLFLKENMDRVTNKVEKVYKDVTVQGKPSHKQKFLKGVCCDFPKLEEKCQEYKERDQAKERDKARRIAYMRQMGRER
What is the function of this protein?
Toxic component of a type III toxin-antitoxin (TA) system (PubMed:19124776).  An endoribonuclease which cleaves between the first and second A of AAAAA sequences; it tolerates other nucleotides in positions +2 and +4 of the consensus.  Digests cognate antitoxin RNA ToxI as shown by the 2'-3'-cyclic phosphate at the 3' end of the 34-nt repeats and probably other RNAs (PubMed:23267117).  Inhibits growth when expressed in E. coli without causing cell lysis; this bacteriostatic effect is neutralized by cognate RNA antitoxin ToxI, which has 2. 9 nearly identical 34 nucleotide-long repeats (PubMed:19124776).  Non-cognate antitoxin RNA from P. atrosepticum does not inhibit this toxin (PubMed:23267117).  The toxin-antitoxin pair function in plasmid maintenance (a plasmid addiction system), but unlike its P. atrosepticum homolog it is not seen to confer resistance to bacteriophages (PubMed:23267117).
What are the official names of this protein?
Endoribonuclease ToxN, Toxin ToxN.
What is the protein family that this protein belongs to?
Belongs to the ToxN/AbiQ toxin family.
Protein: RL14_POLNA
Sequence: MIQTQSKLDVADNTGAKSVMCIKVLGGSKRRYASVGDVIKVSIKEAAPRGRVKKGEVYSAVVVRTAKGIRRGDGSLVKFDGNAAVLLNAKLEPIGTRIFGPVTRELRTEKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SAT9_STACB
Sequence: MASAALFYDSRATIARRLTLHCQYMARAVLFAQCRSAETMLTFILDLSWLFPDENGMRDNTCCYIVATITMALDLLRDRVLAVAVSLDVELLPYVYIVVTHTRLHLLASLLNYPPVHLDVRRMVSEAALHSACEVLRAAVRGEDQLKYIPNNLVIMICYASCISHVPKVRRLVAQLLQFSWTKQGLFTHCVSLLVATLAAKSGSQNSR
What is the function of this protein?
Transcriptional regulator that may regulate the expression of the satratoxin biosynthesis SC1 cluster, one of the 3 clusters involved in the biosynthesis of satratoxins, trichothecene mycotoxins that are associated with human food poisonings (PubMed:25015739).
What are the official names of this protein?
Satratoxin biosynthesis SC1 cluster transcription factor SAT9, Satratoxin biosynthesis SC1 cluster protein 9.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y103_STAA3
Sequence: MKRLNKLVLYISFLILVISFTAGCGIGKEAEVKKSFEKTLSMYPIKNLEDLYDKEGYRDDEFDKNDKGTWIIGSEMVVQPKGERMKSKGMVLYMNRNTKTTTGKYIVSETLHDEDGRPKSKDKEYPVKMVDNKIIPTKGIKDENIKKEIENFKFFAQYGSFKDLSKYKDGDISYNPEVPSYSAKYQLTNDDYNVKQLRKRYKIPTNKAPKLLLKGSGDLKGSSVGYKDIEFTFVEKKGENTFFTDSLHLEPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SAUSA300_0103.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PURT_ECOUT
Sequence: MTLLGTALRPAATRVMLLGSGELGKEVAIECQRLGVEVIAVDRYADAPAMHVAHRSHVINMLDGDALRRVVELEKPHYIVPEIEAIATDMLIQLEEEGLNVVPCARATKLTMNREGIRRLAAEELQLPTSTYRFADSENLFREAVAAIGYPCIVKPVMSSSGKGQTFIRSAEQLAHAWEYAQQGGRAGAGRVIVEGVVKFDFEITLLTVSAVDGVHFCAPVGHRQEDGDYRESWQPQQMSPLALERAQEIARKVVLALGGYGLFGVELFVCGDEVIFSEVSPRPHDTGMVTLISQDLSEFALHVRAFLGLPVGGIRQYGPAASAVILPQLTSQNVTFDNVQNAVGADLQIRLFGKPEIDGSRRLGVALATAESVVDAIERAKHAAGQVKVQG
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: IF3_MYCGE
Sequence: MIQLAQNAKHPSKKEQKPLVNEQIAFNQFTLIDENSTNLGIVKMENALKLAQEKQLDLVLIAPNPTKPIVKLLDFGRYTYDLKRKKRQAKKNQTIIQTKEVVVKPTIAKHDLEFRAKQSKNWIEKGHHVKFIVRAFGRVSTRIELIEKVFDDFYQLVKDVVEIQKPLTASSKTMYAALLVPLKR
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIPA1_MOUSE
Sequence: MWAGGVGSPRRGMAPAPTDDLFARKLRQPARPPLTPNTFEPRPARGPLLRSGSDAGEVRPPTPASPRARAHSHEDASRPAATPTRLFTDPLALLGLPAEEPEPTFPPVLEPRWFAHYDVQSLLFDWAPRPRGTGSHTEANSGTLAEGQTTTSDLLLGAPGFVSELGGEGELGLGGPISPPVPPALPNAAVSVLEEPQTRTTTYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPSVSPRKLLEHVAPRLSPTCLRLGSASPKVPRQLLTLDEQVLSFQRKGGILYCRAGQGSEEEMYNNQEAGAAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHAPCTPHTSYRVAVSRTQDTPAFGPALPEGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRATPRSPGADVQAAGALMWGVRAAPGARVAAGAETSGPDDAEVPCLLGISAETLVLVAPRDGRVVFNCACRDVLAWTFSEHQLDLYHGRGEAITLRLDGAPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFITHVERFTFAETTGLRPGARLLRVCGQTLPKLGPETAAQMLRSAPKVCVTVLPPDESGRPRRSFSELYMLSLKEPSRRGGPEPVQDETGKLVILPPTKQLLHFCLKDSSSPPGPGDLTEERTEFLRTHNSLSSGSSLSDEAPVLPNTTPDLLLVTTANPSAPGTDRETPPSQDQSGSPSSHEDTSDSGPELRASILPRTLSLRNSISKIMSEAGSETLEDEWQSISEIASTCNTILESLSREGQPISESGDPKEALKCDSEPEPGSLSEKVSHLESMLWKLQEDLQREKADRAALEEEVRSLRHNNQRLLAESESAATRLLLASKHLGAPTTDLA
What is the function of this protein?
GTPase activator for the nuclear Ras-related regulatory proteins Rap1, Rsr1 and Ran in vitro, converting them to the putatively inactive GDP-bound state.  Affects cell cycle progression.
What are the official names of this protein?
Signal-induced proliferation-associated protein 1, Sipa-1, GTPase-activating protein Spa-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.
Protein: CRCB2_LEIXX
Sequence: MSRRSSFPVHLHGRSMLLVFVGGALGTAARALLSAAAPTVAVISVITFVINVIGAFVLGWLLESLALRGPDEGRRRDVRLFAGTGVLGGFTTYSAFAVDTDGLIVASNVGGGILYAAATIAIGAAAYLAGIALGAAIGCRRGVSA
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AZOR_SHEDO
Sequence: MAKVLVLKSSILGDYSQSSALIGHLMSHWQQQGAQMTVRDLAADPVPVLDGEIATGMRGGDNLSPRQQQVLDLSDELIAELKSHDTLVIAAPMYNFSIPTQLKNWIDLIARAGVTFTYTETGPKGLLEGKRAVVVTTRGGMHKEGASDHIVPYLKTVLGFIGITEVEFVYAEALNMGPDATAQGLLEAKTALDSLTA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: MACB1_PSEE4
Sequence: MNMTVEWSPQRTRATEQGQPLLRLAGVSRRFMAGDREFLALKDINLQIRAGELVAIIGASGSGKSTLMNILGCLDNASSGSYQVNGQETRDLDDDALAALRRDHFGFIFQRYHLLPHLDALRNVEIPAVYAGVPQAGRHQRARELLTRLGLAGHLANRPSQLSGGQQQRVSICRALMNGGEVILADEPTGALDTASGKEVMNILLELHAAGHTVILVTHDPKVAAHAERIIEVSDGQIVDDRRTVREVAKPVEEVQPAAERAPRRLVASLGLFREAFKMAWIALISHRMRTLLTMLGIIIGITSVVSISAIGEGAKGYVLKDIQAIGSNTIDIYSGKSFGDSRAKAIETLSPADVTALNELYYVDSATPVIGQGSLVRYRNIDADVQLNGVSEQYFQVRNIPLAEGIVFSADDARRQAQVVVIDHNTRKRLFAPGVEALGQVILVGSLPCTVIGVTAENKNLFVAGNSLNVWMPYETAAGRVLGQRHLDSISVRIKDGLPSKRVEEEVNKLMLQRHGTKDFFTNNLDSIMQTVQKTSRSLTLLLSLIAVISLVVGGIGVMNIMLVSVTERTREIGIRMAVGARQSDIRQQFLVEAVMVCLIGGVIGIGLSYGIGYLFALFVKQWEMVFSLGSIVTAFVCSTLIGIVFGFVPARNAARLDPIEALARD
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROQ_BUCAP
Sequence: MKKNINVLLINGPNLNLLGDREKNIYGDKTLSCLINDLKKRSEILNISLNDIQSNAEHVIIEKIHSAKKEKIDYIIINPAAFTHTSIAIRDALIAVTIPFIEVHISNIYARENFRSHSWLSDISKGVITGLGLDGYFWALETISKRCCV
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RPOA_HAHCH
Sequence: MQRSLNEFLTPRTIEVNQINATHAKVTLEPLERGFGHTLGSALRRILLSSMPGCAVVEVEIDGVLHEYSTVEGVQEDVIEILLNLKNLAIKMHNRDEATLSLNKKGAGPVLASDIQLDHDVEIANPDMVICNLNSNGDVKMKLKVARGRGYEPADQRNSADDETRAIGRLQLDSSFSPVLRVAYNVESARVEQRTDLDKLVIDLETNGTIDPEEAIRRAATILQQQLAVFVDFDQQNEPEKVEEQEEIDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIRGDDRVLGG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: EX7S_NOSP7
Sequence: MVKRKGASSSEEGWNYEAKVAEIEGIITRIEAGELELEAVFEQFASAVEYLRQCESFLQQRQQQVDLLIETLSEE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XANQ_ECO57
Sequence: MSDINHAGSDLIFELEDRPPFHQALVGAITHLLAIFVPMVTPALIVGAALQLSAETTAYLVSMAMIASGIGTWLQVNRYGIVGSGLLSIQSVNFSFVTVMIALGSSMKSDGFHEELIMSSLLGVSFVGAFLVVGSSFILPYLRRVITPTVSGIVVLMIGLSLIKVGIIDFGGGFAAKSSGTFGNYEHLGVGLLVLIVVIGFNCCRSPLLRMGGIAIGLCVGYIASLCLGMVDFSSMRNLPLITIPHPFKYGFSFSFHQFLVVGTIYLLSVLEAVGDITATAMVSRRPIQGEEYQSRLKGGVLADGLVSVIASAVGSLPLTTFAQNNGVIQMTGVASRYVGRTIAVMLVILGLFPMIGGFFTTIPSAVLGGAMTLMFSMIAIAGIRIIITNGLKRRETLIVATSLGLGLGVSYDPEIFKILPASIYVLVENPICAGGLTAILLNIILPGGYRQENVLPGITSAEEMD
What is the function of this protein?
Specific, proton motive force-dependent high-affinity transporter for xanthine.
What are the official names of this protein?
Xanthine permease XanQ.
What is the protein family that this protein belongs to?
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS18_CUTAK
Sequence: MAGPQRKSVNKKKVVPIKTVHIGAVDYKDTALLRKFISERGKIRARRVTGLSVQDQRKVAIAIKNARELALLPYASTAR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MGRB_SALG2
Sequence: MKKFRWVVLGIVVVVCLLLWAQVFNIMCNQDVQFFSGICAINKFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: EFNB1_RAT
Sequence: MARPGQRWLSKWLVAMVVLTLCRLATPLAKNLEPVSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCNKPQQEIRFTIKFQEFSPNYMGLEFKKYHDYYITSTSNGSLEGLENREGGVCRTRTMKIVMKVGQDPNAVTPEQLTTSRPSKESDNTVKTATQAPGRGSQGDSDGKHETVNQQEKSGPGAGGSGSGDTDSFFNSKVALFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRAAALSLSTLASPKGDSGTAGTEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
What is the function of this protein?
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7936648).  Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (By similarity).  Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7936648).  Can also bind EPHB2 and EPHB3 (By similarity).  Binds to, and induces the collapse of, commissural axons/growth cones in vitro.  May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
What are the official names of this protein?
Ephrin-B1, EFL-3, ELK ligand, ELK-L, EPH-related receptor tyrosine kinase ligand 2, LERK-2.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane raft. Note=May recruit GRIP1 and GRIP2 to membrane raft domains. SUBCELLULAR LOCATION: [Ephrin-B1 C-terminal fragment]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Ephrin-B1 intracellular domain]: Nucleus. Note=Colocalizes with ZHX2 in the nucleus.
Protein: GLSA_FUSNN
Sequence: MKELLKELVEKNRKFTADGNVANYIPELDKADKNALGIYVTTLDGQEFFAGDYNTKFTIQSISKIISLMLAILDNGEEYVFSKVGMEPSGDPFNSIRKLETSSRKKPYNPMINAGAIAVASMIKGKDDREKFSRLLNFAKLITEDDSLDLNYKIYIGESDTGFRNYSMAYFLKGEGIIEGNVNEALTVYFKQCSIEGTAKTISTLGKFLANDGVLSNGERILTTRMAKIIKTLMVTCGMYDSSGEFAVRVGIPSKSGVGGGICSVVPGKMGIGVYGPSLDKKGNSLAGGHLLEDLSAELSLNIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: PMRD_SALTY
Sequence: MEWLVKKSHYVKKRACHVLVLCDSGGSLKMIAEANSMILLSPGDILSPLQDAQYCINREKHQTLKIVDARCYSCDEWQRLTRKPS
What is the function of this protein?
Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance.
What are the official names of this protein?
Signal transduction protein PmrD, BasR post-transcriptional activator, Polymyxin resistance protein PmrD.
What is the protein family that this protein belongs to?
Belongs to the PmrD family.
Protein: CECR_SHIFL
Sequence: MNNPAMTIKGEQAKKQLIAAALAQFGEYGMNATTREIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGEQFRPHAEEAERLFAQPQPDRAAIRELILRACRNMIKLLTQDDTVNLSKFISREQLSPTAAYHLVHEQVISPLHSHLTRLIAAWTGCDANDTRMILHTHALIGEILAFRLGKETILLRTGWTAFDEEKTELINQTVTCHIDLILQGLSQRSL
What is the function of this protein?
Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol.  Represses the cecR-ybhGFSR operon and activates the rhlE operon.  Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons.
What are the official names of this protein?
HTH-type transcriptional dual regulator CecR.
What are the subcellular locations of this protein?
Cytoplasm.