PharMolix/UniProtQA huggingface dataset:
Protein: AF9_HUMAN
Sequence: MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS
What is the function of this protein?
Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619).  Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749).  Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619).  Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114).  Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749).  In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619).  Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107).  Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PubMed:31776511).  Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511).
What are the official names of this protein?
Protein AF-9, ALL1-fused gene from chromosome 9 protein, Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein, YEATS domain-containing protein 3.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with acylated histone H3 (PubMed:25417107, PubMed:27105114). Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114).
Protein: THP3_SCHPO
Sequence: MKKEHHSPWPDSLKEFIGRCIQDAEENSQPELEDEVKLLISRQYEMGNIWNVDWSSMNLESLRKLTNAQNTIIEDKKRKVEKPVSGNQFSLLSEEDEVDKKEKRRRRFENGSRSQNNAKSEELKVNPENGAIIGRSTELEKRYLRLTSAPDPDTVRPLPVLKQTLELLKKKWKEEKNYAYICDQFKSLRQDLTVQRIQNEFSVLVYEIHARIALEKGDVGEYNQCQTQLFHLYSFGIPGNTKEFLAYRILYMLFTKNRSEMNSLLANLKEEDKTNAAVTHALEVRSAMATGDYYKFFHLYLVAPNMGGYLMDLFIERERVQAMIMMCKAYRPSLTMEFLANTLAFEEMEDCVNFFRSCNAVYDSKDPNRILMKESTDRFEKCMKKHAVVDIKGQI
What is the function of this protein?
Required for transcription elongation.  May also be involved in pre-mRNA splicing (By similarity).
What are the official names of this protein?
THP3 homolog C2A9.11c.
What is the protein family that this protein belongs to?
Belongs to the THP3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DUS3_ASHGO
Sequence: MSSTEGGAKRVAEDGSEVSEAKRVGRIEGVAQLKPEYVVAGAAQLRAAESDEELTSERMVEPEGGTRKKSKKARGQNKNRDNRQAKEEHQLCPRLAQGNADACAFGAQCRYLHDVRTYLEHKTAEIECPQFTGCPVFAATGRCPMGFKCRFLSSHCNMETLELATTPEDERAKLWSVNHEVNHIASDRKLDLVKRRAPFPRSEHVLEIIDAIQQEFRDEMQGAAAAPEGAVAEVPQVQQREEQLSNKRARQRELYAQYHETRYFAQEKKPLDLHHKKIVSPLTTVGNLPFRRLMRQLGADVTYSEMALAVPLIQGTNSEWALPKAHCSELPGFGVQLACSKPWQAAKAAEALADNVGDGLSEINLNSGCPIDLLYRQGSGSALLDNPARMIRCLNAMNYVSKDVPVSVKLRTGTRDGHPIALGLCKRLVMETDVAAITLHGRTRQQRYTRSADWDYVGQVADALRSYETERAEKLKDREGKLRIQFVGNGDCNNWEDWYRHLENENVDSVMVARGALIKPWIFEEVDARQYIDKSSSERLEILRDYARFSMDHWGTDEYGIALCRRYFCEFMSFFHRYVPMGICERYPVLLNERPPNWRGRDDLETLLGSTDAADWIKLSEQFFGPTPDKFVFQPKHKSNSYAPSVQ
What is the function of this protein?
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.  Specifically modifies U47 in cytoplasmic tRNAs (By similarity).  Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
What are the official names of this protein?
tRNA-dihydrouridine(47) synthase [NAD(P)(+)], mRNA-dihydrouridine synthase DUS3, tRNA-dihydrouridine synthase 3.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PRC2A_MOUSE
Sequence: MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPTAPENTPSVPSGVKSWAQASVTHGAHGDGGRASNLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDDLEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHKDSQSAAAEEPETDGKKGTSPGSELPPPKTAWTENARPSETEPAPPTPKPPPPPPHRGPVGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPVTPAAPALPPVVPKEIPAAPALPPTPTPTPEKEPEEPAQAPPVQAAPSPGVAPVPTLVSGGGCTANSNSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPAPKMEPKGDGVGSTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQQQQWQQQQQGTAPPAPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFERHAPPLLRERGTPPVDPKLAWVGDVFTTTPTDPRPLTSPLRQAADEEEKSMRSETPPVPPPPPYLANYPGFPENGTPGPPISRFPLEESAPPGPRPLPWPPGNDEAAKMQAPPPKKEPSKEEPPQLSGPEAGRKPARGGQGPPPPRRENRTETRWGPRPGSCRRGIPPEEPGVPPRRAGPIKKPPPPVKVEELPPKSLEQGDETPKVPKPDALKTAKGKVGPKETPPGGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGSGGTNHPSAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPPPKEGVLGQVPLAPPQPGAPPSPAPARFSTARGGRVFTPRGVPSRRGRGGGRPPPVCSGWSPPAKSLVPKKPPTGPLPPSKEPLKEKLISGPLSPMSRAGNMGVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGADGKPPSLTLAASTPGPEETLTAATVPPPPRRTAAKSPDLSNQNSDQANEEWETASESSDFASERRGDKETPPAALMTSKAVGTPGANAGGAGPGISAMSRGDLSQRAKDLSKRSFSSQRPGMDRQNRRPGTGGKTGSGGGSSGGGGAGPGGRTGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGNVTAPGGHPRPKPGPPQAPQGSSPRPPTRYDPPRASSAISSDPHFEEPGPMVRGVGGTPRDSAGVNPFPPKRRERPPRKPELLQEETVPASHSSGFLGSKPEVPGPQEESRDSGTEALTPHIWNRLHTATSRKSYQPGSIEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGSAEGPPKRPGGPSPLNAVPGESASGSEPSEPPRRRPPASHEGERKELPREQPLPPGPIGTERSQRTDRGPEPGPLRPAHRPGSQVEFGTTNKDSDLCLVVGDTLKGEKELVASATEAVPISRDWELLPSASTSAEPQPKSLGSGQCVPEPSPSGQRPYPEVFYGSPGPPNSQQVSGGAPIDSQLHPNSGGFRPGTPSLHQYRSQPLYLPPGPAPPSALLSGVALKGQFLDFSALQATELGKLPAGGVLYPPPSFLYSAAFCPSPLPDPPLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLLPVVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPNLAVRPPPAPAARVLPSPARPFAPSLGRAELHPVELKPFQDYRKLSSNLGGPGSSRTPPSGRPFSGLNSRLKAPPSTYSGVFRTQRIDLYQQASPPDALRWMPKPWERAGPPSREGPPRRAEEPGSRGEKEPGLPPPR
What is the function of this protein?
May play a role in the regulation of pre-mRNA splicing.
What are the official names of this protein?
Protein PRRC2A, HLA-B-associated transcript 2, Proline-rich and coiled-coil-containing protein 2A.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: O16G_BACF5
Sequence: MSQWWKEAVVYQIYPRSFYDSNGDGFGDLQGVIQKLDYIKRLGADVIWLCPVFDSPQDDNGYDISDYRSIYEKFGTNDDMFQLIDEVHKRGMKIIMDLVVNHSSDEHAWFAESRKSKDNPYRDYYFWKDPKADGSEPNNWGAIFSGPAWSAMSTAQYYLHYFSKKQPDLNWENEAVRREVYDLMTFWMDRGVDGWRMDVIGSISKFVDFPDYETDDSRPYVVGRYHSNGPRLHEFIQEMNREVLSRYDCMTVGEAGGSDVEEAKKYTDPSRHELNMIFTFEHMDIDTKQHSPNGKWQMKPFDPIALKKTMTRWQTALMNVGWNTLYFENHDQPRVISAGAMTRELRKQSRQSISNSSARHEGNPFIYQGEEIGMTNSEMPLEMYDDLEIKNAYRELVIENKTMTEEDFRKAVAKKGRDHARTPMQWDDGKYAGFTDGEAWLAVNPRYQEINVKESLADEDSIFYYYQKLIGLRKQNKVIVYGDYRLLLEEDPRIFAYIREYRGEKLLVP
What are the official names of this protein?
Oligo-1,6-glucosidase, Dextrin 6-alpha-D-glucanohydrolase, Oligosaccharide alpha-1,6-glucosidase, Sucrase-isomaltase, Isomaltase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_DEIRA
Sequence: MSLVVMATGGTGGHIYPAVATAKELRGRGYEVALMGQKGGMEEGIAEREGLTFYGVDAGKLARSGQGRPDPRQLLKAGQGLAQARRTLAGLNPAAVVGYGGFASLPGVLAAQSLGIPTILHEQNARLGLTQRLAVRRARAVGTAYDKVIGLDPRKATLVGMPVREERMPRAEALAALGLRDGPITIMVMGGSQGSLYLNQQVPGILWRLFGKVGKLRGKGDSVPPIDLDLRGPHLIENARSREVQVLHATGPRWLAEVQPKVENLPWYHVTGYVDAVAAWSVADLGITRAGTGTLAEAAFHGVPLVMVPLPESAENHQYHNAVAVEQAGAGRVVEQKVLPETLEKVVLECAAPGKRAAMRDAAQKRARPGAAARFADLIEVQLRRAPSPTAHAPTAHD
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NQOR_ECOSE
Sequence: MAKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: RUVB_CUTAK
Sequence: MSVEHSPVDPSAEPPEKAEEAALRPGALAEFGGQQRVADQLGLVLAASKSRGTTPDHVLLSGPPGLGKTTLAMIIASEMSAPIRISSGPAIQHAGDLAAILSSLVPGEVFFLDEIHRMSKPAEEMLYLAMEDFRVDVVVGKGPGATAIPIEIPPFTLVGATTRAGLLPGPLRDRFGFTAQLDYYEVADLERIVTRSAGVIGVELAEGAAHTIASRSRGTPRIANRLLRRVRDWADVHHESPVTPQGAETALDLYEVDPLGLDRLDRAVLHAVCLKFGGGPVGLSTLAISVGEEPQTVEEVAEPFLVRLGFLMRTPRGRVPTDRAWRHLGLEPPPDSSGEGLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RS212_FRAT1
Sequence: MPRIIVDPKKPFDISLRNFKRACEKAGIKQELRDRQHYVKPTQKRKIAKKAAISKAKKEARRSYSY
What are the official names of this protein?
30S ribosomal protein S21 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: ATPO_PEA
Sequence: QQVPGZKETKIKVPIAMFGGSGNYAXALYIAAVKXNAV
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
What are the official names of this protein?
ATP synthase subunit O, mitochondrial, Oligomycin sensitivity conferral protein, OSCP.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: ITP_HHV6U
Sequence: MTHDNRQLLPQETKLVTPNKDTLSSRYLHVLIIDNTLSTIEFVYMAVKAVLTQVDTLNALEQRKNRPTNRILGLSTSVSKRYINIPKFSSSGASNSQGVKTLAAIRKFCLPDKNCFRNFLSFSTTLFKVPSSIDIYFLFFTASTVSTMAARALDLEFILSSLKNSTSPESLLAATAKIELLSLAADSVTHNRVIAFINRLTPKKYHFDLIRQYAVFYFLNSTTLTSENKLLSAELLYEELSQIPSSSSSGTELENLNNAEVLYVFDRILNSIKMLKNELSSPIGKLRAQPAANDPGTDKTIKYSKIQSIIQKINSFTHENSLLANCRAVVELIDDLYRKLYSWFLHVLTFEDIQFPGDTFLDRLLKMDYCFTYYPSSNRHLIDLFEKTLDNQTFTNLDKFFDTSGNSPELLYQKTFSLKIFSKNLTAQDNGLYIYPLLKTDLSILDFLGTENILFHRGLIYHILHQKTIPQERENDLNKINQFFATVIQQVIETKSSCLPASLSQLLDTIFHFNRIGLNMETCRTYIEILSNHMATPDTQPIINTFTINLTHIVFTAHVFFICMENFSPTFIFYNRKKLILEQQRAILIIERNDYSTLWKQISDHIECLFNVSLSESFFKEYTKGGNEDQKQFLYKNLFEKWGNVFFPFTYSVSTSNNSTAHHITTLELRDICKEVYQSDSPDAYESLLPYSTHPSFKTLFVKIYVIPMVSHITNLTFDKLQSDCRLLTLIHACKLLLPSQHLLLHYMAWLYAFSINVDHIDLGTFTVIKSVIFKIADHINVMTHTIYSPETNLLVSILLNAYTNYLQKYVNPWIKQTITANFSLIQTYITFTKQCASILATKCNINLDNLFIYITIGTDKIVTTSFCSFIATCRNLVRQHEEFEKSLQTIQISEITLTGMLRNIITSVSSSKELLTNEALQKFIDTVQRISQHVNETYHSISVNLEKCKTSNDILIESLKKIIYIVDVLSSNAILNTSLASRCLEAANLAVSNNSFTILEIKKDAVAVFKPFITQLFESMKPTTSLHKKLMSTQKLTTDHIPFLDTFDDRYNLVRHVERQLNWYAAHAEAAQQDLITPLKF
What is the function of this protein?
Plays an essential role in cytoplasmic secondary envelopment during viral egress.  Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs.  Modulates tegumentation and capsid accumulation at the viral assembly complex.
What are the official names of this protein?
Inner tegument protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae inner tegument protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus, host trans-Golgi network.
Protein: Y1317_AGRFC
Sequence: MKLTWLGHSAFRLENGSAKILIDPFFTGNPGFAGQDGKSAAEGITHILLTHGHGDHVGDTVQLARETGATVLANADLAAWLSAKGVAKVDMGNTGGTVHFDGFSVTFTNALHSSAQITEDGVSHSLGNANGLMLHFEDGPAVYHMGDTDIFSDMKLINELHQPDIGLVPIGDRFTMGGAVAALACQRFFKFQNVIPCHYGSFPIIDQTPDKFVAGMEGAEARVHTPKAGDTLSF
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Atu1317.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: Y092_RICFE
Sequence: MKILKSLVLLVLFMAMPAKADDAFSWMSTSFGGLKSLFGCLEVPEFTSFKEGNIGISLSTAGTWQSTGNSVEKGKLLKINWSTSGITPEPRKYLVLYRIDPRFSTPQVFIKTYNYSKLQFEALGFPRFVTDNNSATPGAIPPDKDLDALSFTKMSDSVKYFNYSNGNSRIEVKAGDVVNISLVGKDNFFSPNTLDNILTQELDSSIFAASALYTQSNLGNFDNRIIYSSAKEVCDLIDASRDPDKPSGCSGTGSATKYKSINSNEALVGKPMITRAVQNFMGLINSCPANAGINTSPACYYDQGRGMIIKVGGQVIKERDQSFVNSGSTQSSFIYYQATSGGTMDFTSDWQVNNMFSNSVLMSDWSRNFSNYANFVDYINKNDWSANFLYFGRYSMIVEIGNGANSINPGDQQNISLEYLITSDGTLPDPSVRGTPVDYNFAADAPQDGYLWLRVVNPNSNIQGVVSVNYANYTGTTWFSDIIYNGAIKPITDQFRTFSQNFYIKLVKNSAVQNIAKAALTLYVTIFGLMFVAGALKLTAVEVITRICKIAIVAFLIREESWSFFNTYFFSAFTNGIDFFVTNVVGATSSRANIFGFIDPIFDKYTNGRIWGLLFIELLQIHNGLAFIAIITIYSLITYFRAILEVIIGYVIAFIGLTVMISLAPFFIILMLFEKTKSLFDNWISTLLSYVVQPTILLIFFLLIDQVLSEQLLKVVVRACWDTLIPIKIGLDLTNLGIPINFSFTLPFLPGIPFYVPDVPEISSSNILTNKANTFLVLFTTALLFYSYCLMSYGLVTFVNIVVGMLTNVTPARISGNYQERSDPVGAVMQDIGSVTKPIKKAAMAPARVFKDKIIDQNYKARKPEGGEHTNKFLAERNDVPKKEEGERKE
What are the official names of this protein?
Uncharacterized protein RF_0092.
What is the protein family that this protein belongs to?
Belongs to the TrbL/VirB6 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COXX_OCEIH
Sequence: MNKVEMTYSELIGNTSISNKQKVVMFTSEIKALIKIGIVNSNLITTIAGFLLAISFTSSSFMSNWGTFLLTIIGTALVIAGGCIVNNWYDVDIDPKMSRTKNRPTVTGFFSLKSVLTFGLLTTAVGLLLLMFTSWYATLFAFIGWFGYVVLYTIWSKRRYTLNTVIGSLSGAMPPLIGWAAISPSFHIVPFVMFLIMFIWQTPHFLALAMKKRDEYEAAGIPMLPVVRGMAVTKRQIIVYIACLLPLPFFLLPTMGITFAVIATLLNLGWLAIAFTGLFVDEDKKWANTIFIFSLNYLIILFPLMIIVKLPIFS
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSPO3_BOVIN
Sequence: MHLRLISWFFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPKLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEASEWSPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTSEARKCTVQRKKCPKGERGRKGRERKRKKPNKEESKDAIPDNKGLEPSRETPEQRENKQQQKKRKVQDKQQKSVSVSTVH
What is the function of this protein?
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis.  Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.  Acts as a ligand for frizzled FZD8 and LRP6.  May negatively regulate the TGF-beta pathway.  Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity).  Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity).
What are the official names of this protein?
R-spondin-3, Roof plate-specific spondin-3.
What is the protein family that this protein belongs to?
Belongs to the R-spondin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RASF4_MOUSE
Sequence: MKEACSSSSHVPVSDSKYILKSELLSLLKTYNCYHEGRSFQLRHREEEGTLIIEGLLNIAWGLRRPIRLQMQDDRERVHLPSATWVPERLSYLQKEASPQDSKVPTEEPGTQPANKAEVSGDSSGALEGEEEEVPQLMRTKSDASCIIQRRSKSRAPSEAQKIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTQQVLTLLLNKFRVEDGPSEFALYTVHESGEQTKLKDCEYPLISRILHGPCEKIVKIFLMEADLSEEVPHDVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMLQRLEQLVEAK
What is the function of this protein?
Potential tumor suppressor.  May act as a KRAS effector protein.  May promote apoptosis and cell cycle arrest.
What are the official names of this protein?
Ras association domain-containing protein 4.
Protein: SUFS_WIGBR
Sequence: MNYPIKEIRSDFPILSEKINNSPLIYLDNAASSQKPKCVLQREIIYSSKEHSAVHRGIHTLSKNATKNMEDIRSKIAKFINAKSDSEIIFVKGTTEGINLVANTWGETFIKKGDNIVITQMEHHANIVPWQLLSMRKKVDIKYIPLLPSGKLDICKIDDIINNNTRIFCITHVSNILGTCNLIEKIIKKIKNNYDIKVLIDGAQAIMHMKIDVQKIDCDFYVFSGHKIYGPSGIGVLYGKKKLLKKMPPWEGGGGMIKKVCLFSGTTFNEIPWRFEAGSPNISGIIGLGKSIEYVKKIGIKKIQKYEKKLIKYALLKIKNIPNIKIYSSEINTSIIPFNLKGCHSYDVGILLDKYGVAIRTGHHCSMPIMNFFKVHSMCRISVAMYSDESDIDNFIKSLLKVQKFLRRFN
What is the function of this protein?
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation.  Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine.  Selenocysteine lyase activity is however unsure in vivo.
What are the official names of this protein?
Cysteine desulfurase, Selenocysteine beta-lyase, SCL, Selenocysteine lyase, Selenocysteine reductase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNR6_ENTFC
Sequence: MRKIGYIRVSSTNQNPSRQFQQLNEIGMDIIYEEKVSGATKDREQLQKVLDDLQEDDIIYVTDLTRITRSTQDLFELIDNIRDKKASLKSLKDTWLDLSEDNPYSQFLITVMAGVNQLERDLIRMRQREGIELAKKEGKFKGRLKKYHKNHAGMNYAVKLYKEGNMTVNQICEITNVSRASLYRKLSEVNN
What is the function of this protein?
Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products.
What are the official names of this protein?
Transposon Tn1546 resolvase.
What is the protein family that this protein belongs to?
Belongs to the site-specific recombinase resolvase family.
Protein: RK32_AETCO
Sequence: MAVPKKRTSISKKRIRKKIWKRKGYWTSLKAFSLGKSLSTGNSKSFFVQQNK
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ZBT42_HUMAN
Sequence: MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQEKDRSLDPGNPAPGAEPAQPPCPWPVWTADLCPAARKAKLPPFGVKAALPPRASGPPPCQVPEESDQALDLSLKSGPRQERVHPPCVLQTPLCSQRQPGAQPLVKDERDSLSEQEESSSSRSPHSPPKPPPVPAAKGLVVGLQPLPLSGEGSRELELGAGRLASEDELGPGGPLCICPLCSKLFPSSHVLQLHLSAHFRERDSTRARLSPDGVAPTCPLCGKTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNLSRHTVVHTREKPHACRWCERRFTQSGDLYRHVRKFHCGLVKSLLV
What is the function of this protein?
Transcriptional repressor.  Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 42.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleoplasm. Note=In skeletal myofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions.
Protein: LEUC_BUCBP
Sequence: MKKTLYQKLYDSHIVYEEKSQSPILYIDLHLVHEVTSPQAFFSLCSKNRVVRQPKKTFATMDHNVSTIDRNIDSSGLLAKKQMEALIKNCTKFNIKLFDLNHPHQGIVHVIGPEQGITLPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLKQNRLKSMHIKINGDIDIGITAKDIILFVIKQLGVSRGLGYVIEFSGEIVSKLSMESRMTLCNMSIEMGAKSGIIAPDSVTFSYLCNRKYVPKGKNWNLAIDYWKTLKSDTGAIFDQEFNIDISNLSPQVTWGTNPSQVISINDTIPHLESYSDPIERRSAELSLLYMGLEPGMSLIDVNIQKVFIGSCTNSRIEDLRAVAKIVMNKRVCNSVHAIIVPGSGMVKMQAEKEGLDKIFKNSGFEWRYSGCSMCLAMNDDRLNNKERCASTSNRNFEGRQGRGGRTHLVSPVMAAAAAIFGRFVDVRTIYNSLDK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.