PharMolix/UniProtQA huggingface dataset:
Protein: LFTR_NEIG2
Sequence: MRIPLLAPDNYAFPDPAYALARCDGLVGVSRDLDAGRLLEAYRNGVFPWFSRDGWFFWYAVGPRAVIVPERLHVPRSLAKTLRNGSYRVAVNGCFAEVVAHCAAAARPNQDGTWIAPEFQTAYLKLHEMGHAHSFECHYPDENGKTRLAGGFYGVQIGRVFYGESMFALQPDASKIAFACAVPFLADLGVELIDCQQDTEHMRRFGSELLPFADFAERLRMLNAVPLKEEIGRREVACKGL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATHB8_ARATH
Sequence: MGGGSNNSHNMDNGKYVRYTPEQVEALERLYNDCPKPSSMRRQQLIRECPILSNIEPKQIKVWFQNRRCREKQRKEASRLQAVNRKLTAMNKLLMEENDRLQKQVSHLVYENSYFRQHPQNQGNLATTDTSCESVVTSGQHHLTPQHQPRDASPAGLLSIADETLTEFISKATGTAVEWVQMPGMKPGPDSIGIVAISHGCTGIAARACGLVGLDPTRVAEILKDKPCWLRDCRSLDIVNVLSTANGGTLELIYMQLYAPTTLAPARDFWMLRYTSVMEDGSLVICERSLNNTQNGPSMPPSPHFVRAEILPSGYLIRPCEGGGSILHIVDHFDLEPWSVPEVLRSLYESSTLLAQRTTMAALRYLRQISQEISQPNVTGWGRRPAALRALSQRLSKGFNEAVNGFSDEGWSILESDGIDDVTLLVNSSPTKMMMTSSLPFANGYTSMPSAVLCAKASMLLQNVPPSILLRFLREHRQEWADNSIDAYSAAAIKAGPCSLPIPRPGSFGGQVILPLAHTIENEEFMEVIKLESLGHYQEDMMMPADIFLLQMCSGVDENAVESCAELIFAPIDASFSDDAPIIPSGFRIIPLDSKSEGLSPNRTLDLASALDVGSRTAGDSCGSRGNSKSVMTIAFQLAFEMHMQENVASMARQYVRSVIASVQRVALALSPSSHQLSGLRPPPASPEAHTLARWISHSYRCYLGVDLLKPHGTDLLKSLWHHPDAVMCCSLKALSPVFTFANQAGLDMLETTLVALQDITLDKIFDNNNGKKTLSSEFPQIMQQGFMCMDGGICMSSMGRAVTYEKAVGWKVLNDDEDPHCICFMFLNWSFI
What is the function of this protein?
Probable transcription factor involved in the regulation of vascular development.  May promote differentiation of precambial and cambial cells.
What are the official names of this protein?
Homeobox-leucine zipper protein ATHB-8, HD-ZIP protein ATHB-8, Homeodomain transcription factor ATHB-8.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class III subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YM1_MDBVW
Sequence: MTGLMKAFQKLSPTKRQYAEITQSNSSISSSSSGSKYNDSSSGRYTPLSEEGRTSARASTSTQAQKPASSQQKGGTSSREDEQKLLRKLQTTFGEASNLLNEYVDMRSRKK
What are the official names of this protein?
Uncharacterized protein M1.
Protein: ATPL_ECOHS
Sequence: MENLNMDLLYMAAAVMMGLAAIGAAIGIGILGGKFLEGAARQPDLIPLLRTQFFIVMGLVDAIPMIAVGLGLYVMFAVA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPING_PSEUS
Sequence: HVDKKVADKVLLLKQLRIMRLLTRL
What is the function of this protein?
Active against Gram-positive bacteria B. megaterium and M. luteus, Gram-negative bacteria E. coli SBS363 and D22, K. pneumoniae, S. typhimurium and P. aeruginosa, yeast C. albicans and filamentous fungi F. culmorum, N. crassa, N. hematococca and T. viridae.  Inactive against Gram-positive bacteria B. subtilis, S. pyogenes, B. thuringiensis and S. aureus, Gram-negative bacteria E. cloacae and E. carotovora and filamentous fungus B. bassiana.
What are the official names of this protein?
Spinigerin.
What are the subcellular locations of this protein?
Secreted.
Protein: CD79A_CANLF
Sequence: MPGGPGLLQALCATTFLLFLISAGGLGPGSQALWVDGGPPSMTVSLGETARLQCLHNRSRLSSKLNITWWRVLQGNATWPDIFLSYGKGPNGELTIDTVNKSHMGMYRCQVEEKDLNQKILSSQQSCGTYLRVRERLPRPFLDMGEGTKNNIITAEGIILLFCAVVPGTLLLFRKRWQNMKFGVDAQDDYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLHIGDGDVQLEKP
What is the function of this protein?
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation.  Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells.  Stimulates SYK autophosphorylation and activation.  Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK.  Also interacts with and increases activity of some Src-family tyrosine kinases.  Represses BCR signaling during development of immature B-cells (By similarity).
What are the official names of this protein?
B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Protein: Y2930_BACVZ
Sequence: MNPMIEFCVSNLARGSQEALEILEKDPNLDVLEYGCLSYCGKCMESLFALVNGEVVTGGTPAELVDNIYTFIEENPMF
What are the official names of this protein?
UPF0349 protein RBAM_029300.
What is the protein family that this protein belongs to?
Belongs to the UPF0349 family.
Protein: Y870_STRPZ
Sequence: MYSIKCDDNKAMPRERLMRLGAESLSNQELLAILLRTGNKEKHVLELSSYLLSHLDSLADFKKMSLQELQHLAGIGKVKAIEIKAMIELVSRILATDKTLTDSVLTSVQVAEKMMAALGDKKQEHLVVLYLDNQNRIIEEKTIFIGTVRRSLAEPREILYYACKNMATSLIVIHNHPSGNIEPSSNDYCFTEKIKRSCEDLGIICLDHIIVSYKDYYSFREKSTLF
What are the official names of this protein?
UPF0758 protein Spy49_0870.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: MRP1_CHICK
Sequence: MGIESLCSADASEPFWDWNLTWHTENPDFTQCFQNTVLVWVPCIYLWVCFPAYFLYLRSHDRGYIQMSILNKAKTALGLILWIVCWADLFYSFWERSQNIFRAPFFLISPTVLGITMLLATFLIQHERLKGVQSSGVMMIFWLISLLCATVIFRSKIMLALNTDTEVDAFRYVTFCTYFILLLVQLILSCFPEKPPLFSEAVNDPKPCPEFSASFLSRITFWWITGLMIQGHRRPLEAKDLWSLNKEDTSEEIVPGLAKNWAKEWAKTKRQPLNMLYSSKKQQKSSDSNGEVMEEAEALIIKPSQRSSEASLSKVLYKTFGPYFLMSFLFKAAHDLLMFTGPEILKLLINFVNNKSAPNWQGYFYTGLLFVCACLQTLILHQYFHICFVTGMRLKTAIVGVIYRKALVITNSARKTSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWRNLGPSVLAGVAVMILLVPINAVMAMKTKTYQVAQMKSKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELKVLKKSAYLAAMGTFTWVCAPFLVALSTFAVYVKVNKNNILDAQKAFVSLALFNILRFPLNILPMVISSIVEASVSLKRLRVFLSHEELDPDSIIRGPITNAEGSIVVKNATFSWSKTDPPSLNSINFTVPEGSLIAVVGQVGCGKSSLLSALLGEMDKKEGYVVVKGSIAYVPQQAWIQNATLEDNIIFGREMNESRYKRVIEACALLPDLEILPMGDRTEIGEKGVNLSGGQKQRVSLARAVYCNADTYLFDDPLSAVDAHVGKHIFEKVIGPKGILKNKTRVLVTHAVNYLPQMDTILVMTDGEISEMGSYQELLKQDGAFAEFLRTYANAEQSMESSDASSPSGKEGKPVENGVLVNDATGKLMHRQLSNSSTYSRETGKSQHQSSTAELQKPLAEKNSWKLTEADTAKTGRVKATVYWEYMKAIGLYISFLSVFLFMCNHIASLASNYWLSLWTDDPVVNGTQQYTNVRLGVYGALGISQGIAVFGYSMAVSIGGIFASRHLHLDLLHNVLRSPMSFFERTPSGNLVSRFSKEIDTIDSTIPPIIKMFMGSTFNVIGACIIILLATPIAAVVIPPLGLVYLLVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQKRFIKQNDMKVDENQKAYYPSIVANRWLAVRLEFVGNCIVLFAALFAVIARNKLSPGLIGLSVSYSLQITAYLNWLVRMTSDLETNIVAVERVKEYAEMEKEAEWSIEETAPASTWPQEGKVEFRGFGLRYREDLDLVLKNINITINGGEKVGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGINIAKIGLHDLRFKITIIPQDPILFSGSLRMNLDPFDQHSDEDIWRSLELAHLKNFVSSLPDKLNHECSEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDNLIQSTIKSQFEECTVLTIAHRLNTIMDYTRVLVLDRGEVVECDSPDNLLQAKGLFYSMAKDSGLA
What is the function of this protein?
Mediates export of organic anions and drugs from the cytoplasm.  Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide and other xenobiotics.  Hydrolyzes ATP with low efficiency.  Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (By similarity).  Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (By similarity).
What are the official names of this protein?
Multidrug resistance-associated protein 1, ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, LTC4 transporter.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COAE_CALS4
Sequence: MRVVGLTGGIGSGKSTVSGILAKLGAKIIDADLVSREIMEKGKEAYNEIVDCFGKEILDKEGNIDRKKLGSIVFSDKEKLKRLNEITHPKIIDKIKKMIEEEKDKDKVIVIDAALLIETGLYKLVDEVWLVVVDIDTQIKRVMERDGFSCEEALKRIKSQMPLEEKIKYADFIINNSKDLRKTEEQVRLLWQRFDRRSYFD
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM5_ENCCU
Sequence: MDVMDDVKSVLCLKALEASNERASDCIQRAGASIRKIPRIPSIIRVKKKYSTFRVLTDTSHDLLVLVNEGFSDGEYVPINVELELCYEYFTYSEVLRRILPEEVQTPSSFEIVGSIVHLNLDGEQMKHKNIIGRVVHDKTGKTVITKIGQISNAYRSFDLEVIGGDPVLETIHREGDILFCIDYRSVYWCSKLQSERAILAGKFKAGEVLCDPFCGVGPVSLPALKKGCRVYSNDLNLRAIECLEKSIKINRLDPRNIEIFNLSANEFLEKMAGRKIDHFFLNLPEHSLDYLRRISAWEGNPLVHCYFFCRSNEDVVQYIFSRTGLRVDPGMLKVVRKVSPSKYMYKLETSSLFLRRGLG
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: YSDC_BACSU
Sequence: MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTTDRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQRVTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDMIVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGLRGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLRDAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRDDYENAVKLITEVIKKLDRKTVDEITYQ
What is the function of this protein?
Putative aminopeptidase.
What are the official names of this protein?
Putative aminopeptidase YsdC.
What is the protein family that this protein belongs to?
Belongs to the peptidase M42 family.
Protein: VL2_HPV66
Sequence: MVAHRATRRKRASATQLYKTCKLSGTCPEDVINKVEQKTWADRILQWGSLFTYFGGLGIGTGSGSGGRAGYVPLGSRPSTIVDVTPARPPIVVESVGPTDPSIVTLVEESSVINSGAGVPNFTGSGGFEVTSSSTTTPAVLDITPTSSTVHVSSTTITNPLYIDPPVIEAPQTGEVSGNILISTPTSGIHSYEEIPMQTFAIHGTGNEPISSTPIPGFRRLAAPRLYSRAFQQVRVTDPAFLDNPTTLISADNPVFEGADTTLTFSPSGVAPDPDFMDIVALHRPAFTTRRTGVRFSRLGKKATMQTRRGTQIGARVHYYYDISPIAQADEIEMQPLLSTDNSFDGLYDIYANIDDEAPISFRQSGATPSAQLPIKPSTLSFASNTANVTAPLGNVWETPFYSGPDIVLPTGPSTWPFVPQSPSDVTHDVYIQGATFALWPVYFFKRRRRKRIPYFFADGDVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: TRUD_ECOLI
Sequence: MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGAQRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAAETELQALLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: DEF5_PANTR
Sequence: MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRIGHCTILESLSGVCEISGRLYRLCCR
What is the function of this protein?
Host-defense peptide that maintains sterility in the urogenital system (By similarity).  Has antimicrobial activity against a wide range of bacteria, including Gram-negative E. coli, P. aeruginosa and S. typhimurium, and Gram-positive E. aerogenes, S. aureus, B. cereus, E. faecium and L. monocytogenes (By similarity).  Confers resistance to intestinal infection by S. typhimurium (By similarity).  Exhibits antimicrobial activity against enteric commensal bacteria such as B. adolescentis, L. acidophilus, B. breve, L. fermentum, B. longum and S. thermophilus (By similarity).  Binds to bacterial membranes and causes membrane disintegration (By similarity).  Induces the secretion of the chemokine IL-8 by intestinal epithelial cells (By similarity).  Binds to B. antracis lef/lethal factor, a major virulence factor from B. anthracis, and neutralizes its enzymatic activity (By similarity).
What are the official names of this protein?
Defensin alpha 5, Defensin-5, HD5(20-94).
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored as propeptide HD5(20-94) in secretory granules of small intestinal Paneth cells and found in the ileum lumen as processed mature peptides, predominantly in the HD5(63-94) form. Peptides HD5(20- 94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form (By similarity). Secreted into the female genital tract lumen (By similarity).
Protein: PAXI1_BOVIN
Sequence: MSGQVPRVPEEMFKEVKYYAVGDLDPQVIQLLKAGKAKEVSYNALASHIISEDGDNPEVGEAREVFDLPVVKPSWVILSVQCGALLPVNGFSPESCQIFFGITACLSQVSPEDRSALWAMLTFHGGGCQLNLNRKCTHLVVPEPKGEKYECALRRASIKIVTPDWVLDCISEKTRKDEALYHPRLIVYEEEEEEEEEEEGAGNEEPDSPNEGSTDGKSSPASSQEGSPSGEPPFSPKSSAEKSKGELMFDDSSDSSPEKQERNLNWTPAEVPQLAAAKRRLPPGKEPGLINLCANVPPVPGGILPPEVRGSLLAPGQSLQGPERPEVMAAWSPAMRTLRNITNNADIQQMSSRPSNVAHILQSLSAPTKTLEQQVNHSQQGPASAVLLGQVKVAPEPAPAPQPILHLQPQQLLQLQQQHLAQQPYPPPPPHPFPPPPAHPHQFPQPPLQRPQPPLQQQQLSHLQQQQLQHLQRLQQMQPTPTAQLPGPPAQALQPPPPQAQAQPPLFGHDPAVEIPEEGFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHGGAVDPTFSSRCTHLLCESQVSGLFAQAMKERKRCITAHWLNTVLKKKKLVPPHRALHFPVAFPPGGKPCSQHIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICREPTGLKYEKAKEWRIPCVNAQWLGDILLGNFEALRQTQYGRYTAFGLQDPFAPTPQLVLSLLDAWRVPLKVSSELLMGVRLPPKPKQNEVTNVQPSSKRARIEDIPPPTKKLTPELTPFVLFTGFEPVQVQQYIKKLYILGGEVAESAQKCTHLIASKVTRTVKFLTAISVVKHIVTPEWLEECFKCQKFVDEQNYLLRDAEAEVLFSFSLEESLRRAHASPLFKAKYFYITPGICPSLSTMKAIVECAGGKVLSRQPSFRKLMEHKQNKSLSEIVLISCENDLHLCREYFARGIDVHNAEFVLTGVLTQTLDYESYKFN
What is the function of this protein?
Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes.  Plays a role in early development.  In DNA damage response is required for cell survival after ionizing radiation.  In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs).  Its localization to DNA damage foci requires RNF8 and UBE2N.  Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'.  Together with TP53BP1 regulates ATM association.  Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes.  However, this function has been questioned (By similarity).  Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage.  Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2.  Associates with gene promoters that are known to be regulated by KMT2D/MLL2.  During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes.  Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity).
What are the official names of this protein?
PAX-interacting protein 1, PAX transactivation activation domain-interacting protein.
What are the subcellular locations of this protein?
Nucleus matrix. Chromosome. Note=Localizes to DNA damage foci upon ionizing radiation.
Protein: ARAA_ECO8A
Sequence: MTIFDNYEVWFVIGSQHLYGPETLRQVTQHAEHVVNALNTEAKLPCKLVLKPLGTTPDEITAICRDANYDDRCAGLVVWLHTFSPAKMWINGLTMLNKPLLQFHTQFNAALPWDSIDMDFMNLNQTAHGGREFGFIGARMRQQHAVVTGHWQDKQAHERIGSWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNSISDGDVNALVDEYESCYTMTPATQIHGEKRQNVLEAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQGYGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFEKGNDLVLGSHMLEVCPSIAVEEKPILDVQHLGIGGKDDPARLIFNTQTGPAIVASLIDLGDRYRLLVNCIDTVKTPHSLPKLPVANALWKAQPDLPTASEAWILAGGAHHTVFSHALNLNDMRQFAEMHDIEITVIDNDTRLPAFKDALRWNEVYYGFRR
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: PRMA_SHESR
Sequence: MPWIQLRINTNSDDAETISDLLMEEGAVSITFEDGKDTPIFEPKLGETPLWQDTVVVALFEADTDLAPTIEMLKTLPFLGEHFSHKIEQIEDKDWVREWMDNYHPIQFGKRLWICPSWREVPDPSAVNVILDPGLAFGTGTHPTTALCLEWLDSLDLSNEEVIDFGCGSGILAVAALKLGAKKVTGIDIDYQAIEASKANAERNDVADQLALYLPEDQPADLKADVLVANILAGPLRELAPLIAERVKSGGKLALSGLLKEQAQEISDFYSQWFDMDEAAHKEDWSRLTGKRK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_KLEP3
Sequence: MSRWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLTIEPRTDGQLRLLTPVAGVPDEENLIVRAARLLMRAASESDRLPAGSGADISVDKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSEEELATLGLQLGADVPVFVRGHAAFAEGVGEILTPVEPEEKWYLVAHPGVSIPTPVIFRDPELPRNTPRRSINTLLNCEFSNDCELIARKRFREVDAALSWLLEYAPSRLTGTGACVFAEFNTESAARQVLDTAPAWLNGFVARGVNLSPLKQALL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: KDUI_EDWI9
Sequence: MEVRQSIHSDHAKQLDTAGLRREFLIDTVFDADRYTMVYSHIDRIIVGGIMPVTQSVSIGNEVGKQLGVGYFLERRELGVINIGGPGTIDVDGKCYEIGPREALYVGQGARDLRFASLDSACPAKFYYNCAPAHTHYPNRKITPAEVSPQTLGDTKSSNRRTINKYMVPEVLPTCQLSMGLTELEEGNLWNTMPCHTHERRMEVYFYFNMAPDSCVFHMMGEPQETRHIVMRNEQAVISPSWSIHSGVGTRAYTFIWGMVGENQVFDDMDHLAITDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.