PharMolix/UniProtQA huggingface dataset:
Protein: YCF2_ADICA
Sequence: MVKKVIEKGRGVRGRDYSSKVWDFLEIDALNYFSESLKNHYLEELVVSPASTAEPFIRLSDLRFLSLLFLRNLRHSIMRGSGVTLEMLMLLAIPIFMHCLSYKNSIDRGFVLAKVIDGGEGIRKKQTENYGNFSYDCFLQFKRFLSVGRDGKREILEPYYLGLNKDISISASSSKEEREIRYDVTTPLPSGRWKARIMRRDSLLFGGDRFKGKTEGIQVVRGGRYLQDLVRFFKFYKNLVVSKNGSDCHQNNFDSLLLREICDKQDLGRLQAIRLGNNSLSSVVLYPFESESADSADPRRDGSAFPSEQEVFSNLYSFTSREKTILFRNSISGLDYGEDEGGFPVLHAYSQVRNQLINRLTNFLSIIRKSNLPLGGKIVIDVSNRIKSERVFFPSGMKKNMPFTKISGKKLRLASGGYFDFVEIFPTYFKASLEIPRETTNQNGNTNFLDELEGGGNLDSIYSLVRLYGRNRIIPLYSTYIFLLHDYFCALSTEYFFRIKYWLDGWTGGRVYISFTGIATEETVFKWKDDVERLSNEYVTSHIGQCRNVQSNLYRRLDATRNLYVSPVKKFLGEAMKYNLAELICRVSLVGNELLNKTGVSLRSTNRHTKKYFHRFLDVLFLSKMIVAEATRQKILIDTVDYCIEKLDDIDFEKLNKMDRIELDFFSSLSDGYIDEEILLFKTILEERKSFLVESRLLTSEKSVGSSTALKPASNFTSLGLSCIEAIRAGFSGEALSIMGRQNWNLFVCDLSRGGNSIRNIGESLPKNISDQMDEINNSPIRSRAGNNFIQRIKRGFFVGNCSNSYLDVLENFYLSSDEKAISSSDILSLIHLQLSDSLSSNFSKQTAGEVADHLLTPIQLISPNLHESATIVTHLDGLPNSISDLNGLLASLSSSPREATDSFLFSCSNDGVSLEEASRNSDSWSDHQRTQPRRNLLVLDRVNSEKFFKDGLDSRNGSPTSQVYRNGLSIEYFWEPKKLDTPYWSLRFSLFNGVTSRFIAGSIGEDVTRQDAGFADSSAREEATCPSHFINFNELSEDLNRYKISWIFWRDSIGENWSLLGDYIPLFFTPTWWRYFCDLITKAYPEIVLKISYDSNHDLRRISEGIARGLVGSAKGYLLRSLQRLGLIFGNNSINTISSETDLLILEKIPDKAEILHPGEWSVSQFSNRPISYCCILSILLVLLSLKHPLSAVSGSNFFHLWKRFATIDYLTDPMRGSYLRKVMYSPPTSQMLTRDLLIHSLNRFLNCVSNILFFLFVKNEIDSWIFRRESSDILDSNKELLTQHLVTTKILYRYASKSKFNYDLSSNKIFHEPYPQDRSNVLAYLLQFWQNDLLGHKIRKLDPAEKWAFSALGRDILFSATTRRRDSLLNMPCRDIPISLQSGLLPSKGILLVGPVETGRSSLIRDVASNSYFPVVKLPLKKFIYNRSFFNNVRGNFISKESVHRLNIVFEIAKEMSPCTLWIQDIHELNICRSYNKLEADPKFLLCQILKSIGHKLGNSDIRENVVIATTHVPARIDPALVAPNRLNQLINFRRSNGRQRQKELSILLRIKGFEVGANPTLLESTVSGTAGYSKRDLLLLANEALLIGTSKGRKFVCSNTIGLALHRQHSTVSDMGNEMESNSEWEISSYKMAEVKNSLTDISLTTFPFIGRDELKMRFYYLSNWYVEPSTTESTIDEFTMFLHLPELIAKLVARDSFQMDRGKEDNFIVIDKLVENDLNLACGVLENLSNNFPRPEICRGESRRSNSFPPPLPIGKPKYCSGVTSLSRSSKSLKRGRISSLTDFEMQQSPELRNSAAEISREITWSRKAWRLRFLRSGTYELMGVLSEPNHLYNLILLYYNQNYIPQQDFEFSKIRGKRSKWREKSGYLFSFEKSVTNGTDNSIKRLENRLDNMLLREQFLELGISGDSSNEYETHCDRLNEMTRLFGGRFIWDPMLLFQPDPNIPSLRRNLLSTKELARRLHTIYGMRRQRLQKMSNNKIKDFFLYSEENPKLKPDSSLNRRNNLPLEEEERDSEYVRETSSVDIHLQYPQIFTPVRLGCYAVAEDFPERFLRFRLLVHRNKWLRRNRSPFRDFLIYNMLLETYEYLSNPFRFGKASLD
What is the function of this protein?
Probable ATPase of unknown function.  Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis.
What are the official names of this protein?
Protein Ycf2.
What is the protein family that this protein belongs to?
Belongs to the Ycf2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: NDK_MANSM
Sequence: MSLERTFSIIKPDAVERNLIGKILARFEQSGFEIVAAKMVRLTKAQAEGFYAEHQGKPFFEDLVEYMVSAPILVSVLQKENAVKDYRTLIGATDPAKAKEGTVRKEFAESLRRNSVHGSDSLESAAREIAYFFIDSEICSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GH_HHV2H
Sequence: MGPGLWVVMGVLVGVAGGHDTYWTEQIDPWFLHGLGLARTYWRDTNTGRLWLPNTPDASDPQRGRLAPPGELNLTTASVPMLRWYAERFCFVLVTTAEFPRDPGQLLYIPKTYLLGRPRNASLPELPEAGPTSRPPAEVTQLKGLSHNPGASALLRSRAWVTFAAAPDREGLTFPRGDDGATERHPDGRRNAPPPGPPAGTPRHPTTNLSIAHLHNASVTWLAARGLLRTPGRYVYLSPSASTWPVGVWTTGGLAFGCDAALVRARYGKGFMGLVISMRDSPPAEIIVVPADKTLARVGNPTDENAPAVLPGPPAGPRYRVFVLGAPTPADNGSALDALRRVAGYPEESTNYAQYMSRAYAEFLGEDPGSGTDARPSLFWRLAGLLASSGFAFVNAAHAHDAIRLSDLLGFLAHSRVLAGLAARGAAGCAADSVFLNVSVLDPAARLRLEARLGHLVAAILEREQSLVAHALGYQLAFVLDSPAAYGAVAPSAARLIDALYAEFLGGRALTAPMVRRALFYATAVLRAPFLAGAPSAEQRERARRGLLITTALCTSDVAAATHADLRAALARTDHQKNLFWLPDHFSPCAASLRFDLAEGGFILDALAMATRSDIPADVMAQQTRGVASVLTRWAHYNALIRAFVPEATHQCSGPSHNAEPRILVPITHNASYVVTHTPLPRGIGYKLTGVDVRRPLFITYLTATCEGHAREIEPKRLVRTENRRDLGLVGAVFLRYTPAGEVMSVLLVDTDATQQQLAQGPVAGTPNVFSSDVPSVALLLFPNGTVIHLLAFDTLPIATIAPGFLAASALGVVMITAALAGILRVVRTCVPFLWRRE
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL.  May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity).  Interaction with host integrins ITGAV/ITGB3 triggers release of cytosolic Ca(2+) and FAK phosphorylation leading to efficient viral entry into host genital tract epithelial cells (PubMed:24942591).
What are the official names of this protein?
Envelope glycoprotein H, gH.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein H family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: RLMN_PARP8
Sequence: MTSSPTVNLLDLDAAGLVAYCDSLGEKPFRAKQLQRWIHQYNAADFDGMTDLAKSLREKLKGRASITMPPVVSDHISSDGTRKWLVDVGNGNAVETVYIPEETRGTLCVSSQAGCAVNCRFCSTGKQGFSRNLGTGEIIGQLRMAEFALRASRGTAGGRATGGDGKGERVVTNVVMMGMGEPLLNYDAVVPAMRLMLDDNAYGLSRRRVTLSTSGVVPMMDRLGADLPVALAVSLHAPNDALRDELVPLNKKYPLRELMAACQRYLKVAPRDFITFEYCMLDGVNDSEAHARELLAVTRDVPCKFNLIPFNPFPESGLLRSKSEQIKRFAQVLMDAGVVTTVRKTRGDDIDAACGQLAGAVKDRTRLAERTGKGKVIEVRAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_MYCPU
Sequence: MSMNKKIAIFPGSFDPFHNGHKHILNKALALFDLVYLVITINPDKITKTSFDQRKTLLENEILDFDKSRVQVLVNKDSLTAEIAKKLGAKFIIRSARNDIDYQYELVLAAGNKKINNEVETILIFPDYDKIEINSTLIRHQKFIENLKK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASGL1_XENLA
Sequence: MKPVIVVHGGAGKIVEELDATYRAGVKRAVLKGYDVLSQGGSALTAVEEAVIVLEDEQIFNAGHGSVLNEKGDIEMDAIIMDGKNLDSGAVSAIRNIANPIKLARLVMEKTDHMLLTCEGATLFAKAQGIPEVPNESLVTERSRKRWMKNLKENSNPVADQIGLGTVGAVAIDCEGNVACATSTGGLTNKMVGRVGDTACIGSGGYADNNVGAVSTTGHGESIMKVILARLILHHMEQGKSPEEAADAGLNYMKSRVGGIGGVIIVNSSGDWTAKFSTNQMSWAAVKDDQLHIGIYHGENNVTPLEKAL
What is the function of this protein?
Has both L-asparaginase and beta-aspartyl peptidase activity.  Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn.  Likewise, has no activity toward glutamine.
What are the official names of this protein?
Isoaspartyl peptidase/L-asparaginase, Asparaginase-like protein 1, Beta-aspartyl-peptidase, Isoaspartyl dipeptidase, L-asparagine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the Ntn-hydrolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y958_METJA
Sequence: MKKFILFLIILLFSIYFLNVSSAEVCPFKDGFIIIYHDIGYDKLFGYTYNDSEILYFNNKNLMDITPISDYYFPELYHNITYFECGSTNNLTILSFGYFYFPKNGDGIVFLGVLVYTTKNNKINYTEKILWADVFYSVDDFDISPPACSPNEALLVYCYKMKADYPENILVLINNTNITELKKFEDDDYYTTFQHYIYQPIFIFTTYDSKAKKFYILDGRLSNTSFPLYSYYGGKIHFEDNITLPKYENISWECMDFYSINGTLYIVMKKLNCSNINYAGWYEDYLNQKPYLLIWKNKTIKIISNCSNPYYFVKIKGGEIPIEKSYLKKIFGNKYESIRITDLAYNNGILLIETNENHKLHYYIVKNNSIEEIKLKNIIKLYKKKHSLWDDIKKELEPKIYWVIHNWYIIVLIIAGLLWMAILWKK
What are the official names of this protein?
Uncharacterized protein MJ0958.
Protein: KDSA_TRIL1
Sequence: MTKELSIGSVKMGGGRLLVLIAGPCVIESEEATLRHAERLMTICNGLGMPLIFKSSYDKANRTSINAFRGPGMDEGLRILSKVKESLGIPVLSDIHSIEQVAPAAQVLDVLQIPAFLCRQTDLVVAAAKTGKVVNVKKGQFLAPWDMRNVVGKVAASGNENIILTERGASFGYNNLVVDMRSFPVMRSYGYPVVFDATHSVQLPGGQGESSGGQREFVETLSRAAVATGIDGIFMEVHEDPSCALCDGPNSIPLAELPALLKRLQALDAVVR
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCC4_DROMO
Sequence: MSVVSTTPASQDACYISLLGLAEYFRTSQPPNIKKCIQCLQALFTFQPPSKVEARTHLQMGQVLMAYTCNIDLARRHLEQAWSIAEPLMNFDDVKFDTASLLAQLHLKTEQSSHAKAMLRRAVELSQNNVYWHCKLLLQLSQIHASDREYSLASDLLAVGAESAEEAGATYLKVLFLLSRAMILMIERKTNDVLALLNSAGQIIDNNIPNPHQKEYLKVFFLVLQVCYYLALGQVKTVKPSLKQLQMSIQTIMAPNWPSDETIFGGNQLEMFVWLPKEQLYVLVYLVTVSHSMMAGYMDKAQKYTEKALTQIEKLKQQEDKSILSVFKVILLEHIVMCRMVMGNRELAIREIAAARDVCLAVPHRNLLKRHSAQLHCLIGLYSMSTSFFEHAERQFLVCVNETTERDLKLFANLNLAIIYLRTKREADLKQILDAVSTENTHTYSSQALMGGFYYVQGLHAFHKNSFHEAKRFLRETLKMANAEDLNRLTSCSLVLLSHVFLSIGNSKESMNMVTPAMQLASKIPDIHVQLWGSAILKDLHRMSKDAQHEKEAYANHVKYSENLIADQRKCVQSAHHELINWFQGNPPVTSNSSLNPAVTVPTTETSTSALQQPQQPAAQFGQFY
What is the function of this protein?
Required for association of the cohesin complex with chromatin during interphase.  Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity).
What are the official names of this protein?
MAU2 chromatid cohesion factor homolog, Cohesin loading complex subunit SCC4 homolog.
What is the protein family that this protein belongs to?
Belongs to the SCC4/mau-2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Note=Binds to chromatin from the end of mitosis until prophase.
Protein: 3603L_ASFB7
Sequence: MQPSTLQALAKRALATQHVSKDDYYILERCGLWWHEAPISIYIDDDNQIMIRTLCFKEGIKLNTALVLAVKENNEDLIMLFTEWGANINYGLLFINNEHTRNLCRKLGAKEELETSEILRFFFETKCKITSSNVILCHELFSNNPFLQNVNMVDLRMIIYWELKDLPTNSMLNEISFSEMLTKYWYGIAVKYNLKEAIQYFCQEYRHFDEWRLICALSFNNVFDLHEICNTTKIHMSINKMMELACMRDNNFLTIYYCFALGANANRAMLISVKNFCIENMFFCMDLGANVIEHSKTLADIYGYSIIVNILSLKIYKANPILLSKETNPEKINTLLKNYYSKNMLAYDICCIDNYL
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-3L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: IMAND_PSECP
Sequence: MKIIAADVFVTSPSRNFVTLRITTEDGVTGIGDATLNGRELAVAAYLKEHVAQLLIGKDPHRIEDTWQFLYRSSYWRRGPVTMAAIAAVDMALWDIKGKVAGMPVYQLLGGASRNGLRAYGHASGADIPSLFDSVREHLELGYKSIRIQTAVPGIKAVYGVAAQAQASGERYDYEPAGRGAFPVEEDWDTRAYLRHLPSVFEAVRNEFGPEIPLLHDGHHRMTPIQAAKLGKALEPYDLFWLEDCTPAENQEALRLVRQHTTTPLAIGEIFNTVYDYQTIIKEQLIDYVRAASTHFGGISPLKKVMDFAAQYQIKSGFHGPTDISPVGFAAQLHVGLAIHNYGIQEYMQHSDKTNEVFHQSMTFKDGYLHPGDEPGIGVEFNEEAAAAFPYQQAYLPYNRLVDGTVHDW
What is the function of this protein?
Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding.  May have evolved a divergent function.
What are the official names of this protein?
D-galactonate dehydratase family member Achl_0790.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: HRCA_ACIAC
Sequence: MLDDRAKLLLKALIERYIADGQPVGSRTLSRSSGLDLSPATIRNVMADLEDIGLIASPHTSAGRIPTAKGYRLFVDTMLTVQRGELCSPELAPDQPQKVIANAAQLLSSLSQFVGVVMAPRRPSVFRHIEFLRLSERRLLVIIVSPDGDVQNRVIFTEVDHSQSQLAEAANFLNSHYSGLGMEEVRERLKTEVDQLRGEIASLMQAAVNVGSEAMAASQEEVVISGERNLLALSDFSNDMGNLRKAFDLFEQKTQILRLLDVSNRAEGVRIFIGGESQVVPFEELSVVSAPYEVDGQVVGTLGVIGPTRMPYDRMIQIVDITSKLVTNALSHRR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ZN423_DROME
Sequence: MMALKMLYRGPSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTMTPNSHHLIGAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQCQFCEKTFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGGTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERESRPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLVCPHCGMSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKEANSPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPLQVDTNALKAQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNSQPPAPQATAPPPPPNASTATFSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTGKHKCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASLPLACICCRQTLHSEFELSLHAKFHTKSSSSGGSLQEPVCALCLEPLPDATEGPAKLCDKCCRKHNLNGKRGKHSEPATSLPAPPSAFVENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHMGEHGAHSRPYDCNLCPEKFFFRAELEHHQRGHELRPQARPPAAKVEVPSIRNTSPGQSPVRSPTIVKQELYETDTVESAGVEDEPENHPDEEEYIEVEQMPHETRPSGIGSQLERSTSSA
What is the function of this protein?
Probable transcription factor that can both act as an activator or a repressor depending on the context (By similarity).  Involved in posterior spiracle development.  Acts downstream of ems and cut in posterior spiracle development.
What are the official names of this protein?
Zinc finger protein 423 homolog, O/E-associated zinc finger protein.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DPH4_ASPFU
Sequence: MIKSQTPRHDYYHILNLPFTTPPAALSKQQLKIAYHKALLKHHPDKAISVAATPARTHTHDTKTAYRSSPDRNADTSPTFTIDEITAAYKTLSDPALRAEYDRVLRLERVTAGKGDKGAEAAFHTGLEVVDLEDLVCEEMGDGEGLLCWYRGCRCGDERGFMVTEKDLEKEAEHGEVVIGCRGCSLWMKILFAMEEGDG
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue.  Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
What are the official names of this protein?
Diphthamide biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the DPH4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LPXB_BURVG
Sequence: MPLPTNQLRLAMVAGEPSGDLLAASLLGGLQARLPASTHYYGIGGQRMLAHGFDSHWQMDKLTVRGYVEALGQIPEILRIRGELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSIHFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAGVASTYVGHPLADEIPLEPDTHGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQEREPGVRFVMPAATPALRELLQPLVAAHPQLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEVFTEMHLSLRQNTAAKAAEAVVRVLEQRKGRA
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: TATA_RHOPB
Sequence: MGSLSIWHWIVVIGVVLLLFGRGKISDLMGDVAQGIKSFKKGLQDDEKTAEKPEPVKSIDHTAPPAAAPRTDVGSKVV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: VPB32_MYCTU
Sequence: MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Upon expression in M. smegmatis neutralizes the effect of cognate toxin VapC32.
What are the official names of this protein?
Antitoxin VapB32.
What are the subcellular locations of this protein?
Secreted. Note=Following 6 weeks of nutrient starvation (PubMed:23345537).
Protein: SOTC_BACF6
Sequence: MKKFTCVQDIGDLKSALAESFEIKKDRFKYVELGRNKTLLMIFFNSSLRTRLSTQKAALNLGMNVIVLDINQGAWKLETERGVIMDGDKPEHLLEAIPVMGCYCDIIGVRSFARFENREYDYNEVIINQFIQHSGRPVFSMEAATRHPLQSFADLITIEEYKKTARPKVVMTWAPHPRPLPQAVPNSFAEWMNATDYEFVITHPEGYELDPKFVGNARVEYDQMKAFEGADFIYAKNWAAYTGDNYGQILSTDRNWTVGDRQMAVTNNAYFMHCLPVRRNMIVTDDVIESPQSIVIPEAANREISATVVLKRLLENLP
What is the function of this protein?
Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline (PubMed:16704984).  Is essential for arginine biosynthesis (PubMed:12095263, PubMed:16704984).  Has no activity with either L-ornithine or L-aspartate as substrate (PubMed:12095263, PubMed:16704984).  Has also no detectable AOTCase activity, being unable to convert N(2)-acetyl-L-ornithine to N(2)-acetyl-L-citrulline (PubMed:16585758, PubMed:16704984).
What are the official names of this protein?
N-succinylornithine carbamoyltransferase, N-succinyl-L-ornithine transcarbamylase, SOTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.
Protein: ARP3_CHICK
Sequence: MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVVDQAQRRVLKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAVKERFSYVCPDLVKEFNKYDTDGTKWIKQYTGINAISKKEFTIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
What is the function of this protein?
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity).  Seems to contact the pointed end of the daughter actin filament (By similarity).  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
What are the official names of this protein?
Actin-related protein 3, Actin-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Protein: OSPC2_SHIFL
Sequence: MKIPEAVNHINVQNNIDLVDGKINPNKDTKALQKNISCVTNSSSSGISEKHLDHCADTVKSFLRKSIAAQSYSKMFSQGTSFKSLNLSIEAPSGARSSFRSLEHLDKVSRHYLSEIIQKTHPLSSDERHLLSIIINSDFNFRHQSNANLSNNTLNIKSFDKIKSENIQTYKNTFSEDIEEIANHDFVFFGVEISNHQETLPLNKTHHTVDFGANAYIIDHDSPYGYMTLTDHFDNAIPPVFYHEHQSFFLDNFKEVVDEVSRYVHGNQGKTDVPIFNTKDMRLGIGLHLIDFIRKSKDQRFREFCYNKNIDPVSLDRIINFVFQLEYHIPRMLSTDNFKKIRLRDISLEDAIKASNYEEINNKVTDKKMAHQALAYSLGNAKSDMALYLLSKFNFTKQDIAEMEKMNNNMYCELYDVEYLLSEDSANYKVLEYFISNGLVDVNKRFQKANSGDTMLDNAMKSKDSKTIDFLLKNGAVSGKRFGR
What is the function of this protein?
ADP-riboxanase effector that mediates arginine ADP-riboxanation of host caspases (PubMed:34671164, PubMed:35338844).  ADP-riboxanation of host apoptotic caspases (CASP3 and CASP9) prevents their activation, thereby inhibiting host cell extrinsic and intrinsic apoptosis (PubMed:35338844).  Does not catalyze ADP-riboxanation of host CASP4/CASP11 or CASP8 (PubMed:34671164, PubMed:35338844).  In contrast to Ospc1 and OspC3, not able to inactivate host calmodulin (PubMed:35568036).
What are the official names of this protein?
Arginine ADP-riboxanase OspC2.
What is the protein family that this protein belongs to?
Belongs to the OspC family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the type III secretion system (TTSS).
Protein: KPTA_NOSP7
Sequence: MSDSRLVKISKYLSKYLRHTPDAIGIKLAPGGWVAVDELITACAKNKFPITRQELEAVVESSEKQRFSFDSTGTLIRANQGHSVEVDLQLEPVVPPDELYHGTGHKSVDSIMETGLCKMSRHHVHLSKDIATAQTVGARHGKPVVFAISAAAMHQAGYIFYCSDNGVWLVDRVPPEYLQKI
What is the function of this protein?
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P).  May function as an ADP-ribosylase.
What are the official names of this protein?
Probable RNA 2'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: RL22_PSEA7
Sequence: MEVAAKLSGARISAQKARLVADQIRGKKVGEALNLLAFSSKKAAEIMKKVLESAVANAEHNEGADVDDLKVSTVFVNEGRSLKRIMPRAKGRADRIVKRSCHITVKVADK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RLMM_ECOBR
Sequence: MNKVVLLCRPGFEKECAAEITDKAGQREIFGFARVKENAGYVIYECYQPDDGDKLIRELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELLKFCRKFTVPLRAALRDAGVLANYETPKRPVVHVFFIAPGCCYTGYSYSNNNSPFYMGIPRLKFPADAPSRSTLKLEEAFHVFIPADEWDERLANGMWAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFKFRPTRSNISWMVCDMVEKPAKVAALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYIQAQLDEHGINAQIQARQLYHDREEVTVHVRRIWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.