PharMolix/UniProtQA huggingface dataset:
Protein: NGLY1_DROME
Sequence: MVDINLECVHQIEPKTRSAGQQQQERGLKEAYLEAVRILLVLLENILAQPENSMFRTIRQENKAIKEKLLSLPGCERLLEAIGFVRAPSSNAYTLPTEVSLQQVKKYRDALSERRTAWLNGTVSKSPPQQSTTSTTPLFIKPSVEYRHRIAFPRVLRTNNNFLQSLELYSDAVMQYEDNLLLATGRTLIPVEELTEMASEKLIDIQDQIASGERQEKEPCVRDLLLVELVNWFNTQFFQWVNNIPCRVCGSEESRLRRTEREGDIRVEVTVCCGQESKFYRYNDISQLLVSRKGRCGEYANCFTFLCRALDYDARIVHSHFDHVWTEVYSEAQMRWLHVDPSENVIDSPLMYQHGWKRHIDYILAYSRDDIQDVTWRYTNDHQKILHLRKLCGEKEMVQTLDAIRAKRRQNCTADRKLFLSQRNMYEVIGLTLERKPTENELKGRSSGSLSWRQSRGEHTFTNIFVFNLSATELQKRQLNVRYSCATDTYERYAKEGEHITILDSYKTWQKAQFSSKNIFRKVERDWKMAYLARLEDTDCGEIAWTFDFSKTNLKVKSYNLVFETKTFGDGKISVTVDATDGSASVENATGFKIVAKLTGGKGDVAWQHTQLFRQSLNSRDYPFDLQVQLH
What is the function of this protein?
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation.  Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp.  Prefers proteins containing high-mannose over those bearing complex type oligosaccharides.  Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins.  Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity).
What are the official names of this protein?
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, Peptide:N-glycanase.
What is the protein family that this protein belongs to?
Belongs to the transglutaminase-like superfamily. PNGase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPP_YERPB
Sequence: MNEQYSAMRSNVSMLGTLLGDTIKEALGEHILDRVETIRKLSKSSRAGNEASRQELLTTLQNLSNDELLPVARAFSQFLNLTNTAEQYHSISPHGEAASNPEALAQLFTRLKDKKLSDQDMRSAVDDLSIELVLTAHPTEITRRTLIHKLVEVNTCLSQLDHNDLADYERNKIMRRLRQLVAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWEGVPAFLREFNEQLENSLDYRLPVEAVPIRFTSWMGGDRDGNPNVTAEITRHVLLLSRWKATDLFLRDIQVLVSELSMSECTPELRELAGGEEVLEPYRQLMKNVRTQLTNTQAYLEARLKGERVLPPHDLLVSNDQLWEPLYACYQSLKACGMEIIANGQLLDTLRRVRCFGVPLVRIDVRQESTRHTDAIAELTRYLGLGDYESWSESDKQAFLVRELNSKRPLVPLKWEPSAETQEVLETCRVIAEAPQGSIAAYVISMAKVPSDVLAVHLLLKEAGCPFTLPVAPLFETLDDLNNADDVMTQLLGIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYRAQDALIKTCEKAGITLTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKFGLPEVTISSLALYAGAILEANLLPPPEPKKEWIEVMDLLSDASCDMYRSYVRENPEFVRYFRAATPELELGKLPLGSRPAKRRPDGGVESLRAIPWIFAWTQNRLMLPAWLGAGAGLQRAIDAGKRDVLATMCRDWPFFSTRIGMLEMVFAKADLWLAEYYDQRLVDKSLWPLGQQLRDQLAADIKVVLAIANDDHLMADLPWIAESIALRNVYTDPLNVLQAELLHRSRQQEHPDACVEQALMVTIAGVAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: RL29_STACT
Sequence: MKAKEIRDLTTSEIEEQIKSSKEELFNLRFQLATGQLEETARIRTVRKTIARLKTVAREREIEQSKANQ
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: M1_I66A0
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEVALSYSAGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASITAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKDNLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: NU4LC_LIRTU
Sequence: MMTEHVLILSAYLFSIGIYGLITSRNMVRALMCLELILNAVNLNLVTFSDLFDSRQLKGDIFSIFVIAIAAAEAAIGPAIVSSIYRNRKSTRINQSNLLNK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic, NAD(P)H dehydrogenase subunit 4L, NADH-plastoquinone oxidoreductase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CDD_ACTSZ
Sequence: MNDCIGKRLDKLINESQDEVLKRVVGQILEQNGKARISQDWVRRCGDDFNLTAVELALRCLPVAACYASAPVSHFNVGAVAVGQSGAFYFGANQEFSGDAVQQTVHAEQSAVSHAWLAGEVALTDMVVNYTPCGHCRQFMNELNSADRLQIHLPHSRNNRLHSYLPDAFGPKDLNISRVLFDPQPHSFGFTHADPLVQAAADAAEQAYAPYSRALSGVALQVGTQSITGRYAENAAFNPSFLPLQCALNYRRLSGLSDVPVSRIVMAESQGGLSHRSITEQLAHSYLGLEIEYFAL
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: GMT_MAGO7
Sequence: MADKKNEDFVVRMPDNGTVEKEPFLARSPPARARTGSGGGFGDSFSLARVANNPPAAILAYCLSSISMTVVNKYVVSGSEWNLNFFYLAVQAIVCIIAILFCKQIGIITNLAPFDNVKAKKWFPVSLLLVGMIYTSTKALQFLSVPVYTIFKNLTIIAIAYGEVLWFGGSVSPLALVSFGLMVLSSVVAAWADIQSAIHGGSHPSEASTAISTLNAGYAWMGMNVFCSAAYLLGMRKVIHKMNFKDWDSMFYNNLLTIPVLIVCSLIAEDWSAANLARNFPIESRNALFIGMIYSGLGAIFISYCSAWCIRVTTSTTYSMVGALNKLPIAISGLVFFSAPVTFGSVSAIVIGFISGIVYAWAKARQSSQAKSALPTQQPVMSASSQSNKDASNS
What is the function of this protein?
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
What are the official names of this protein?
GDP-mannose transporter, GMT.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DPHB_METPE
Sequence: MLTFVGLGLYDAGDISVKGLEAVRASDAVFLEYYTSRLMGTTIEDLVRAYGKEVIVLARADVEQHPEPILDAAAAGDVVVLTGGDPMVSTTHMDLRLRAAARGIPTGIIHGASIQTAVCGLTGLQNYRFGKSCSVPFPQKNWFPLTPYEVVRQNLAADLHTLVYLDIQQDRYMRVGEAIDLLEEMAVRVGGSITTYIGVARAGSVSPVVRAGTADHLRGIDFGGPLHVLIVPATLHPVEQEYLEVFAGLSV
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: LIPA_BORPE
Sequence: MSTLVESPVPSNDSQAAAPAAYDPTQKQKSQAKTARIPIKVVAAEKLKKPEWIRVRAAAPGSRFYDIKRILREHNLHTVCEEASCPNIGECFGKGTATFMIMGDKCTRRCPFCDVGHGRPDPLDTQEPENLARTIAALKLSYVVITSVDRDDLRDGGAAHFVECIAKVREYSPDTRIEVLVPDFRGRLDRALHILNSGPPDVMNHNLETVPRLYKQARPGSDYAHSLKLLAEFKKLHPEVPTKSGLMLGLGETDEEILQVMRDMREHNVDMLTIGQYLQPSEHHLPVLRYVHPDTFAMFEREAYAMGFTHAAVGAMVRSSYHADQQAHAAGVN
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_STRZT
Sequence: MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKIDMIVGPEARGFIVGCPVAFELGIGFAPVRKPGKLPREVIFADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVVAGCAFLVELDELNGREKIGDYDYKVLMHY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_SHEPC
Sequence: MISFSSFYQQIADSNLQHWLETLPSILGKWQRDHKHGNLPKWEKVLNKLHYPAPDQVDFVDSVTVGSGEQLSPGEKEKLENLLRLFMPWRKGPFHIHGIHIDTEWRSDWKWDRVKQHISPLKNRTVLDVGCGSGYHMWRMLGSGAKRVVGIDPSPLFLCQFEAVKRLAGPHHPVHLLPLGIEELPPLDAFDTVFSMGVLYHRRSPIDHLLQLRDQLRTGGELVLETLVIDGDENAVLVPQDRYGKMNNVWFIPSVAALMLWLKKCDFTDIRCVDTDVTALAEQRRTDWMPNESLVEYLDPNDITKTVEGYPAPKRATIIAIKNQPNQETVNG
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: YQGF_ORITI
Sequence: MIINSIIEFLQAADIKKQILGIDFGEKKVGVAISNIEHTVAMPLQTIFATNQDRINKIQEIAVAYNIGAIVIGLPFKLDGTETSQTHRVKDFANKLANKLLLPIFLCDERLTSKAANNLLKMGNIKRKVRNAIDDRVAASIILEGTLKRMQNSKSYF
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSG2_TRYEQ
Sequence: MFTQAVIALIGLVSIRTGKTEDVTPCTTNCGCWARLEKQITVYRGDYSAAEENLKENKKNFGKIIAATVLGSEKLKATVAPVLLSAAQIIHECEEALTTARPAILDAEKKVAELRALYDVQQKLKEGNGELQLHIQDDTNINTAKEVPKANLGNINKKGCADDLNTPDAATIDKTNIETEGPTPKVITHVHVEARCQRDGTPTNGCHDGQLGQNGKLEFSLTYDSKDTNDLATWLADTATKKQISATEVDFIGNLNTEANTAIKGLKSSNPAPACSKKIRDYKTIADNSKFNLMVTKALIGKTDAEAGQESKEPELAAAITKYYGTEGTKFEDQLWKAIERTPAYLGDQKKEQTTKIEKLETLTEVGEATARGLVKQLAAGAQARQTASGDDQSAENQCGGKKEDECKDGCELVEGVCKPVKQGEGENKEKTGTTNTTGSNSFVIKKAPLWLAFLLF
What is the function of this protein?
VSG forms a coat on the surface of the parasite.  The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
What are the official names of this protein?
Variant surface glycoprotein 20, VSG-20.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Note=A soluble form is released from ruptured cells by the action of a PI-PLC.
Protein: LEU3_NOSS1
Sequence: MTQNYRITLLPGDGIGPEIMAVAVDVLKVVGQQFDIQFDFQEALIGGAAIDATGEPLPSATLDTCRHSDAVLLAAIGGYKWDSLPPHQRPEGGLLGLRAGLELFANLRPAQILPQLIDASTLKREVVEGVDIMVVRELTGGIYFGKPRGIFTTETGEKRGVNTMVYTESEIDRIGRIAFETARKRRGKLCSVDKANVLDVSQLWRDRITNLSQEYPDVELSHLYVDNAAMQLVRAPKQFDTIVTGNLFGDILSDAAAMLTGSIGMLPSASLGASGPGVFEPVHGSAPDIAGQDKANPLAQVLSAAMMLRYALDQPQAADKIEQAVLQVLEQGDRTGDIISVGMNLLGCRGMGDSLIKALAKS
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUE1_CANAL
Sequence: MDSSTVLFIGAVAVAFIFLKWMVSPIPPQNEFTIDHLSQDQSTGSTTSSNAHQNRDTHSISTQSHRNSRRAVSESMIEVVQSIAPMLTVEQIRYDLETTGNVEATVNRFMELGDLPFPPGYVRPQQPPTPSEEPKKQEVIGKRSVNLLEKYNIDAKNPKSDHNSLLHQRRQEMILGARKRLAAQLSNEL
What is the function of this protein?
Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway.  Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system.  Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).
What are the official names of this protein?
Coupling of ubiquitin conjugation to ER degradation protein 1.
What is the protein family that this protein belongs to?
Belongs to the CUE1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RS3_STAAR
Sequence: MGQKINPIGLRVGIIRDWEAKWYAEKDFASLLHEDLKIRKFIDNELKEASVSHVEIERAANRINIAIHTGKPGMVIGKGGSEIEKLRNKLNALTDKKVHINVIEIKKVDLDARLVAENIARQLENRASFRRVQKQAITRAMKLGAKGIKTQVSGRLGGADIARAEQYSEGTVPLHTLRADIDYAHAEADTTYGKLGVKVWIYRGEVLPTKNTSGGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: DDX19_DICDI
Sequence: MSEKETNTTSTENKEKEKQEQTNTNSTTESTNNQVDEEYERPGRSEGLDEFGIQLDIQQSDPNSPLYSVKTFEELGLKPELLKGVYAMGYNKPSKIQEAALPIIIQSPNNLIAQSQSGTGKTAAFTLGMLNCVDPSINAPQAICISPTKELALQTFEVISKIGQFSNIKPLLYISEIEVPKNVTNQVIIGTPGKILENVIKKQLSVKFLKMVVLDEADFIVKMKNVPNQIAMINRLLPSNVKVCLFSATFSMGVEELIKKIVQDPYTSIRLKRQELSVEKIHQYFIDCGSEDNKALILSDIYGFISVGQSIVFVHTIATAKSVHQKMVDEGHSVSLLYGKDLTTEERFKQIKDFKDGKSKVLITTNVLARGIDIPQVSLVINYDVPLDEMGKPDPVHYLHRIGRVGRFGRSGVALSFVYDQQSTNKLMNISTHLGVPLKELKSSEIESLDGILKGIRNQLTPLNN
What is the function of this protein?
ATP-binding RNA helicase required for normal differentiation and development.
What are the official names of this protein?
ATP-dependent RNA helicase ddx19, ATP-dependent RNA helicase helC, DEAD box protein 19.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
Protein: MURB_STAA9
Sequence: MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIDVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGEHPKES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARSB_ECO57
Sequence: MLLAGAIFVLTIVLVIWQPKGLGIGWSATLGAVLALVTGVVHPGDIPVVWNIVWNATAAFIAVIIISLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLGAAVAALFANDGAALILTPIVIAMLLALGFSKGTTLAFVMAAGFIADTASLPLIVSNLVNIVSADFFGLGFREYASVMVPVDIAAIVATLVMLHLYFRKDIPQNYDMALLKSPAEAIKDPATFKTGWVVLLLLLVGFFVLEPLGIPVSAIAAVGALILFVVAKRGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTEYLSGVLNVLADNGLWAATLGTGFLTAFLSSIMNNMPTVLVGALSIDGSTASGVIKEAMVYANVIGCDLGPKITPIGSLATLLWLHVLSQKNMTISWGYYFRTGIIMTLPVLFVTLAALALRLSFTL
What is the function of this protein?
Involved in arsenical resistance.  Thought to form the channel of an arsenite pump (By similarity).
What are the official names of this protein?
Arsenical pump membrane protein, Arsenic efflux pump protein.
What is the protein family that this protein belongs to?
Belongs to the ArsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BCHB_RUBGI
Sequence: MQLTLWTYEGPPHVGAMRVATALDDVHYVLHAPQGDTYADLLFTMIERLPRRPPVTYTTFQARDLGGDTAELFKTACSQAFERFRPNAMLVGASCTAELIQDDPGGLARALALPIPVVPLELPSYQRKENWGASETFYQVVRTLAGPRAPAPGTPRPAREPGAKPCCNLLGPTALGFRHRDDVREITGLLNELGIEVRTVAPLGASADDIARLGEADFNVVLYPETAQQAAGWLQRFFGQPFTKTIPIGVKATKAFIAEVLQLAGLPADTPLPDALSRSPWYSRSVDSTYLTGKRVFIFGDATHAIAAARVATEEMGFTVVGLGTYSREFARDVRDAAKHYGVEALITDDYLEVEAKVAELHPELVLGTQMERHIAKRLGVPCAVISAPVHVQDFPARYSPQMGFEGANVLFDSWVHPLMMGLEEHLLTMFRGDFEFHDGAAASHLGRAAVPPPAAAPAPAAESSDVPAVAETATAAATVAAPAASAPITVAQWAPDAQKELQKIPFFVRGKARRNTERFAAERGLATITVETLYDAKAHFGR
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: UBIX_ALKPO
Sequence: MSERIEKIMTVGITGASGGMYGVRLTQELLRQEYKVHLVLTEAAWQVFKEELLLDTTDRQKVIHELFGDLPGELHTHDLHDYAAPIASGSYRSAGMVIIPCSMGTLSGMAHGASGNLLERTADVMLKEKRKLVIVPRETPLHDIHLENMLKLSKMGATILPAMPGYYHLPKTIDDLINFLVGKALDSLGVEHTLFTRWGE
What is the function of this protein?
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD.  The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
What are the official names of this protein?
Flavin prenyltransferase UbiX.
What is the protein family that this protein belongs to?
Belongs to the UbiX/PAD1 family.
Protein: YJJB_KLEAK
Sequence: MGIISYLFDLAQDMALAAIPAVGFAMVFNVPQRALRWCALLGAIGHGSRMVMMSAGFNIEWATFLAALLVGSIGIQWSRWYLAHPKIFTVAAVIPMFPGISAYTAMISAVKISHFGYSEEMMIMLLSNFLKASSIVGALSIGLSIPGLWLYRKRPRV
What is the function of this protein?
Involved in succinate export with YjjP.  Both proteins are required for export (PubMed:29395959).  Participates in succinate export, but also in the export of other dicarboxylates, such as fumarate and malate (PubMed:29395959).  Contributes to succinate production under both aerobic and anaerobic conditions, and increases fumarate and malate production during anaerobic succinate production (PubMed:29395959).
What are the official names of this protein?
Probable succinate transporter subunit YjjB.
What is the protein family that this protein belongs to?
Belongs to the ThrE exporter (TC 2.A.79) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRIMM_HUMAN
Sequence: MSKRLSPQLQHNITEDAYCETHLEPTRLFCDVDQITLCSKCFQSQEHKHHMVCGIQEAAENYRKLFQEILNTSREKLEAAKSILTDEQERMAMIQEEEQNFKKMIESEYSMRLRLLNEECEQNLQRQQECISDLNLRETLLNQAIKLATELEEMFQEMLQRLGRVGRENMEKLKESEARASEQVRSLLKLIVELEKKCGEGTLALLKNAKYSLERSKSLLLEHLEPAHITDLSLCHIRGLSSMFRVLQRHLTLDPETAHPCLALSEDLRTMRLRHGQQDGAGNPERLDFSAMVLAAESFTSGRHYWEVDVEKATRWQVGIYHGSADAKGSTARASGEKVLLTGSVMGTEWTLWVFPPLKRLFLEKKLDTVGVFLDCEHGQISFYNVTEMSLIYNFSHCAFQGALRPVFSLCIPNGDTSPDSLTILQHGPSCDATVSP
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase TRIML2, RING-type E3 ubiquitin transferase TRIML2, SPRY domain-containing protein 6, Tripartite motif family-like protein 2.
Protein: S39A9_HUMAN
Sequence: MDDFISISLLSLAMLVGCYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHQASETHNVIASDKAAEKSVVHEHEHSHDHTQLHAYIGVSLVLGFVFMLLVDQIGNSHVHSTDDPEAARSSNSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSMVTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKPDATGGRGLSRLEVAALVLGCLIPLILSVGHQH
What is the function of this protein?
Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:25014355, PubMed:19420709, PubMed:28219737).  Participates in the zinc ions efflux out of the secretory compartments (PubMed:19420709).  Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (PubMed:23505453).  Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity).  This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity).  Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription (PubMed:34555425).  Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (PubMed:25014355, PubMed:28219737).
What are the official names of this protein?
Zinc transporter ZIP9, Solute carrier family 39 member 9, Zrt- and Irt-like protein 9, ZIP-9.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NUCS_FRASN
Sequence: MRLVIARCSVDYIGRLKAHLPSAVRLLLVKADGSVSIHADGRAYKPLNWMSPPCVIAEEEGVWRVTNKAEEQLVISIEQILHDSTHELGVDPGLRKDGVEAHLQVLLADRPDAVREGLTLVRREYETGIGPVDLLCRDADGSTVAVEIKRKGEIDGVEQLTRYLSRLDDDPALPHPVRGILCAQSITPQARLLAADRGIACSVVDYDALRGLEPSIPTLF
What is the function of this protein?
Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
What are the official names of this protein?
Endonuclease NucS.
What is the protein family that this protein belongs to?
Belongs to the NucS endonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.