PharMolix/UniProtQA huggingface dataset:
Protein: PA11_POLDO
Sequence: MNFKYSILFICFVKVLDNCYAADDLTTLRNGTLDRGITPDCTFNEKDIELHVYSRDKRNGIILKKEILKNYDLFQKSQISHQIAILIHGFLSTGNNENFDAMAKALIEIDNFLVISVDWKKGACNAFASTNDVLGYSQAVGNTRHVGKYVADFTKLLVEQYKVPMSNIRLIGHSLGAHTSGFAGKEVQRLKLGKYKEIIGLDPAGPSFLTNKCPNRLCETDAEYVQAIHTSAILGVYYNVGSVDFYVNYGKSQPGCSEPSCSHTKAVKYLTECIKRECCLIGTPWKSYFSTPKPISQCKRDTCVCVGLNAQSYPAKGSFYVPVDKDAPYCHNEGIKL
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylcholine with phospholipase A1 activity (By similarity).  May act as an allergen and induce hemolytic activity (By similarity).
What are the official names of this protein?
Phospholipase A1 1, PLA1 1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: ASTB_SHEON
Sequence: MKHFEANFDGLVGPTHNYAGLSFGNVASLNNAALVSNPKAAAKQGLQKAKALADLGMIQGMLAPQERPDLNTLRRIGFSGSDAQVLQQAAKTAPALLNACCSASSMWTANAATVSPSADTRDGKLHFTPANLVDKLHRSIEPITTGRILTATFNDPHYFYHHNHLPEHNSFGDEGAANHTRLCQEYGHAGVELFVYGQEATNPHAPKPLKFPARQTLEASMAIARLHQLEEDNCVFIQQNPAVIDQGVFHNDVIAVGNQNVLFYHEQAFLNTQAKLDEIKRKLDTELYFIEVPTAKVSINDAVKSYLFNTQIITLPSGEMAIIAPTDCQENPAVYAYLNELLSLNTPIKQVLYFDVKQSMQNGGGPACLRLRVAMNEREVAAVNQHTLLTDALFTRLNTWVEKHYRDRLSTEDLADPQLVIESRTALDELTQIMKLGSVYPFQR
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: FOLD_MYCBT
Sequence: MGAIMLDGKATRDEIFGDLKPRVAALDAAGRTPGLGTILVGDDPGSQAYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGVSRTDDGLVGDVHPDVWELAGHVSPNPGGVGPLTRAFLLTNVVELAERR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: FEOC_CITK8
Sequence: MASLIQVRDLLALQGRMEAMQISRTLHTPQPMIDAMLNQLENMGRAVRIQEDPDGCLSGSCKSCPEGKACLREWWTLR
What is the function of this protein?
May function as a transcriptional regulator that controls feoABC expression.
What are the official names of this protein?
Probable [Fe-S]-dependent transcriptional repressor.
What is the protein family that this protein belongs to?
Belongs to the FeoC family.
Protein: KR192_MOUSE
Sequence: MSYYSGYSGGLGYGYGSSFGGLGCGCNSIRRLGCGSGYGGFGYGSGYGGFGGFGYGSGYGGYGYGSGYGGFGGFGYGSGYGGFGYGSGYGGFGGFGYGSGYGGYGYGSGFGGYGYGSGFRGYGCGCRRSSCCGGYGFSSFY
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 19-2, Keratin-associated protein 16-1, Keratin-associated protein 16.1.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 19 family.
Protein: SRP54_ECOL6
Sequence: MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.  Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
What are the official names of this protein?
Signal recognition particle protein, Fifty-four homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: COBS_MYCS2
Sequence: MIRSLAGAFAFGTVLPVRASAGVGRGALTALPFVGLALGALAAAVVWAGGWAFAAGSPLPGVLAVAVLLLATRGLHIDGFCDTVDGLGCYGPPERALAVMRDGSAGPFGVAAVVVVIAVQALTFAELSVLAVVTAVVAGRVAVVAACRRSVPAAAGSTLGAAVAGSQPRWVVAGWIVALAALAVFACPRPWQGPLAVLVAIGCSLALVAHCVRRFGGITGDVLGAAVEVTTTLAALGLAIG
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CWC24_CANAL
Sequence: MFKKRVIKDSRVSKRKIGDINEASEDAPDTQVTKKSTLITKKSDIQKKSVVMPRSSPQTPLSKSSSDDAAAVEVVSQKSKKGELKPLAANIKTTIITDFQPDVCKDFQQTGYCGYGDTCKFLHVRDESRQKIPIKKDWEIGGQKEVKEKEDIPFKCVLCKSDYKSPIKTECGHIFCKACFLDRYKAKKKGTCFICHKETNGTMVPVNIDKLSATQV
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC24.
What is the protein family that this protein belongs to?
Belongs to the CWC24 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ABCD4_MOUSE
Sequence: MAVPGPTARAGARPRLDLQLVQRFVRIQKVFFPSWSSQNVLMFMTLLCVTLLEQLVIYQVGLIPSQYYGVLGNKDLDGFKALTLLAVTLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHHLYFRARVYYTLNVLRDDIDNPDQRISQDVERFCRQLSSVTSKLIISPFTLTYYTYQCFQSTGWLGPVSIFGYFIVGTMVNKTLMGPIVTKLVQQEKLEGDFRFKHMQIRVNAEPAAFYRAGLVEHMRTDRRLQRLLQTQRELMSRELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPTELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGELQEALLDMSRKSQDCEALGESEWDLDKTPGCPTTEPSDTAFLLDRVSILAPSSDKPLIKDLSLKICEGQSLLITGNTGTGKTSLLRVLGGLWEGMKGSVQMLADFGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSADDERIVRFLELAGLSSLVARTGGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEAESELYRIGQQLGMTFISVGHRPSLEKFHSWVLRLHGGGSWELTRIKLE
What is the function of this protein?
Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner.  Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane.  Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane.
What are the official names of this protein?
Lysosomal cobalamin transporter ABCD4, ATP-binding cassette sub-family D member 4, PMP70-related protein, P70R, Peroxisomal membrane protein 1-like, PXMP1-L, Peroxisomal membrane protein 69, PMP69.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein.
Protein: LMRA_STRLN
Sequence: MSVFARATSLFSRAARTRAADEAARSRSRWVTLVFLAVLQLLIAVDVTVVNIALPAIRDSFHVDTRQLTWVVTGYTVVGGGLLMVGGRIADLFGRRRTLLFGAFLFGASSLAAGLAPNLELLVLARFGQGAGEALSLPAAMSLIACSSRTAPFQGVERLASVASVGLVLGFLLSGVITQLFSWRWIFLINIPLVSLVLVAVLLLVKKDETTARNPVDLPGALLFTAAPLLLIFGVNELGEDEPRLPLAVGSLLAAAVCAAAFVAVERRTAHPLVPLTFFGNRVRLVANGATVLLSAALSTSFFLLTMHLQEERDLSPIEAGLSFLPLGLSLILACVLVRGLIERIGTTGAAVLGMALAGPRHRLFALLPSDNSLLTSVFPGMILLLRMATGLVALQNAALHAVTEADAGVASGVQRCADQLGGASGIAVYVSIGFSPHLGGDWDPFTVAYSLAGIGLIAAVLAVLALSPDRRLAAPREQED
What is the function of this protein?
Proton-dependent transporter.  May mediate the efflux of lincomycin.
What are the official names of this protein?
Lincomycin resistance protein.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLPK_PARP8
Sequence: MQDQYILALDQGTTSSRAMLFDRNGNVVSVAQKEFRQIYPHPGWVEHDPLEIWATQAGVAAEAVTHAGLNGTSIAAIGITNQRETTIVWDRQTGHPIYNAIVWQDRRTADFCDQLKAQGLEDEVRAKTGLPVDSYFSATKIRWILDNVEGAREKAKQGKLAFGTVDSWLVWNFTKHELHITDVTNASRTMLFNIHTLQWDDALLDALDIPRSMLPEVRPSSEVYGPTKTTVFASKIPLAGIAGDQHAALFGQMCTRSGMVKNTYGTGCFLVMNTGTKPIESKNNLVTTIAWQIGDQINYALEGSIFIAGAVVQWLRDGLGIIRSASEVETLARGVEHCDGVYLVPAFAGLGAPHWNARARGTLFGVTRGTTSAHIARAALDSIAYQSMDVLKAMEADSGIHINELRVDGGACANNLLMQFQADILGVDAVRPQVSETTALGAAYLAGLATGYWKDIEELQNQWKLEHRFSPSLPADQAKACLDGWQRAIRAAKAWADAP
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: LPXD_XANAC
Sequence: MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVLRADDAEAAKGTALVAKDPYTAFAKIAALFDLAPVREPGIHASAVIDPTAQVSATAHVGPFVSIGARSRVGDGCVIGTGSIIGEDCVVDAGSELLARVTLVTRVRLGKRVRIHPGAVIGADGFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNCRIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEYSSGTPLTDNRTWRKNAARFKQLDVLARRILAVGKEKE
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: PG135_VACCC
Sequence: MSCYTAILKSVGGLALFQVANGAIDLCRHFFMYFCEQKLRPNSFWFVVVRAIASMIMYLVLGIALLYISEQDDKKNTNNDGSNNDKRNESSINSNSSPK
What is the function of this protein?
Envelope protein.  Required for an early step in virion morphogenesis.
What are the official names of this protein?
Virion membrane protein OPG135.
What is the protein family that this protein belongs to?
Belongs to the oerthopoxvirus OPG135 family.
Protein: C560_RECAM
Sequence: MISINFNFLKIKGIINMNINRPISPHLTIYKLQITNTLSIFHRITGGVLALTLCFFILILKMLNFHLSSYAFYSIAYTLNQYSGFLFIAISFFLLLFIFYHLFAGLRHLVWDAGYALEIENVYLTGYIMLGLAFLFTLIAWIIF
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase cytochrome b560 subunit, Succinate dehydrogenase, subunit III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b560 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RUVA_STRPF
Sequence: MYDYIKGQLTKITAKYIVVEANGLGYMINVANPYSFTDSVNQLVTIYLHQVIREDAHLLFGFHTEDEKDVFLKLISVSGIGPTTALAIVAVDDNEGLVNAIDNSDIKYLMKFPKIGKKTAQQMVLDLAGKFVEAPQETGHTKARSNKAGNTQLDEAIEALLALGYKAKELKKIRAFFEGTSETAEQYIKSALKLLMKG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: MNME_BURP1
Sequence: MLATDSDPIVAIATASGRGGIGVVRLSLGRAGEAAARALSDALCGARLMPRHASYVPFLDGAGEPLDRGIALYFPAPHSYTGEHVIELQGHGGPIVLQLLLQRCLDAGRAHGLRLAEPGEFTRRAFLNDKLDLAQAEAVADLIEASSEAAARSAGRSLDGAFSRDIHALVDDVIALRMLVEATLDFPEEEIDFLEAADARGKLAHIRERLAHVLGDARQGALLREGLSVVLAGQPNVGKSSLLNALAGAELAIVTPIAGTTRDKVAQTIQIEGIPLHIIDTAGLRETEDEVEKIGIARTWGEIERADVVLHLLDARSGLGPGDEAIAARFPDGVPVVRVLNKTDLTGAPASVTRTGGGAARADVCEVRLSAKRGDGIDLLRGELLRIAGWQAGAESVYLARERHLIALRAAQAHLARAAEHAEQNAQALDLFAEELRLAQERLNSITGEFTSDDLLGVIFSRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSH_DROME
Sequence: MLHEALMLEIYRQALNAGALPTARPRSTESANSSERCPSHDSNSSEHGGGAGSGGVGHRLDAAALSTGVMPGEGPTTLHSSFPAVPQSLPSQPPSMEAYLHMVAAAAQQYGFPLAAAAAAGAGPRLPLPLANEAAAPFKLPPQASPTASSNNSEALDFRTNLYGRAESAEPPASEGEEEEFDDGANNPLDLSVGTRKRGHESEPQLGHIQVKKMFKSDSPPANSVASPSASQLLPGVNPYLAAVAAANIFRAGQFPDWNSKNDLVVDPLEKMSDIVKGGASGMGTKEKMHSSKATTPQAASQPPKSPVQPTPNQNSESGGGSGGGAAGSGAVTKARHNIWQSHWQNKGVASSVFRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISIKSGNANANSDAKESHNSLSSEESRTLSAVLTCKVCDKAFNSLGDLSNHMAKNNHYAEPLLQSAGARKRPAPKKREKSLPVRKLLEMKGGSGTTQEDHSNEKTSVQGKPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNKSPELVEQKNGGSAKAAGASSVLSAIEQMFTTSFDTPPRHASLPASSPSNSSTKNTSPVASSILKRLGIDETVDYNKPLIDTNDPYYQHYRYTSSERSGSECSAEARPRLDAPTPEKQQQGGGHDEESSKPAIKQEREAESKPVKMEIKSEFVDEPNEAEETSKMEAAVVNGSATNNNNNIVERSSPKTPSSAASPQTRLLPPRSPAESQRSVTPKSPASSHKSYDGSSEGTKKFPSDSLNALSSMFDSLGSSGAGANSRAKLAAAAAAGGSESPENLTAGGNSLAALRQFCVKKEKTA
What is the function of this protein?
Homeotic protein that acts downstream of Arm in the Wg cascade during embryogenesis to determine segment identity throughout the entire trunk.  Acts cooperatively with other trunk homeotic proteins to repress head homeotic genes and therefore repress head segmental identity.  Necessary, in combination with Scr, for the formation of the prothoracic segment.  Promotes eye development in the dorsal region of the eye disk and suppresses eye development in the ventral region in combination with Wg-signaling and several early dorso-ventral eye patterning genes.  Required for proper development of proximal leg segments.  Has differential functions along the dorso-ventral axs of the antennal and leg disks.  May play a role in wing hinge development.  Possible involvement in chromatin structure for modulation of transcription.  Binds DNA and can act as both a transcriptional repressor and activator.  Positively regulates its own expression as well as that of Dll.  Negatively regulates the expression of mod.  Required for Wg-mediated transcriptional repression of Ubx in the midgut.  Also represses transcription of lab in the midgut and is necessary for the proper formation of anterior and central midgut structures.  Tiptop (tio) and teashirt (tsh) have, on the whole, common activities.  Tio and tsh repress each other's expression and tsh has a crucial role for trunk patterning that is in part masked by ectopic expression of tiptop.  Both genes share a common activity required for the activation of Ser and svb and the maintenance of en and wg.
What are the official names of this protein?
Protein teashirt.
What is the protein family that this protein belongs to?
Belongs to the teashirt C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Initially localized in the cytoplasm soon after the blastoderm stage, and becomes nuclear by stage 9.
Protein: LACB_STAA1
Sequence: MKIALGCDHIVTDTKMRVSEFLKSKGHEVIDVGTYDFTRTHYPIFGKKVGEQVVSGNADLGVCICGTGVGINNAVNKVPGVRSALVRDMTSALYAKEELNANVIGFGGRIIGELLMCDIIDAFINAEYKATEENKKLIAKIKHLETSNADQADPHFFDEFLEKWDRGEYHD
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacB.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: RL28_SALSV
Sequence: MSRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRVSAKGMRIIDKKGIETVLSELRARGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: NO66_DROWI
Sequence: MDPETLDDLVNELFDKKKQLTVSQKQQREKLQAYMMAQLEGSSSASDDDDEDDGEGEDDNDSNSDEDESGSESDATSADDSFSSDDNDDDDSGDEDGSDSGGSDSDLSFEDDSDYEDSHSTEDLTEYTINSENSSVEPTPPKRLKAGDKRPCSTQEEEESEDDNNNKPTARKLQMGESATNGRIQQRKSMVEPATTSKPASCPLTRKSLPANGSAAKSCPLPPKNQKQSAAAKSCPLPPKEKKLSSGAVAKSCPLPPKNEKPSSSGASCPLPSKTSKQVQPRVCQLSDKPKSSSSQSTQKRSKNEAAEGATDTNGRQEAHRQNSIEEGRRILSWVLNPIKPDDFFKDFWEKNACQVQRNAPTYFSELISFEMIDQMMLKHHLEFTTNIDVTSYKDGRRETLNPEGRAMPPTVWGFYGEGCSIRILNPSTYLPGLRTMCSLMQEFFHCLVGANVYLTPPNSQGFAPHFDDIEAFVLQVEGRKRWRLYMPLQPSDVLARESSGNYTPDQLGEPIFDEVLKPGDVLYFPRGTVHQAITEKKHHSLHITLSVYQQQAYANLLEKLMPMVLQSAIKHSVSLRRGLPLHTWQHLGIAHGATKCSSRSQLIKGIQEMVQQHLTPSENQIDAAVDQLAKRYQHEALPPTILPEEKLRTVFGSRSATDAHGKCLCDYELTEDTSIRLLRANILRLVVDETHLRVYYYVDNALEYCKYEANFMEIEPTEAAAVETLMHAYPAYVKISMLPLRKPERRIEVATALWERGLLMTETPFK
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
What are the official names of this protein?
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Histone lysine demethylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CD48_MOUSE
Sequence: MCFIKQGWCLVLELLLLPLGTGFQGHSIPDINATTGSNVTLKIHKDPLGPYKRITWLHTKNQKILEYNYNSTKTIFESEFKGRVYLEENNGALHISNVRKEDKGTYYMRVLRETENELKITLEVFDPVPKPSIEINKTEASTDSCHLRLSCEVKDQHVDYTWYESSGPFPKKSPGYVLDLIVTPQNKSTFYTCQVSNPVSSKNDTVYFTLPCDLARSSGVCWTATWLVVTTLIIHRILLT
What is the function of this protein?
Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:9881969, PubMed:21278219).  Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex.  In turn, promotes LCK phosphorylation and subsequent activation (PubMed:9881969).  Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (By similarity) (PubMed:9881969, PubMed:21278219).
What are the official names of this protein?
CD48 antigen, BCM1 surface antigen, BLAST-1, HM48-1, MRC OX-45 surface antigen, SLAM family member 2, SLAMF2, Signaling lymphocytic activation molecule 2, sgp-60.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Protein: Y1032_MYCPA
Sequence: MYLAVEIGTVDLNPVLKGAVATILYFAVGMAVLLVGFYAVDLLTPGKLRQLVFIDRRPNAVVVAGAMYIALTVVIITAIANSYSQLGQGLVGVAVYGLMGVILLGVALLAMHLLIPGSFHEHVEEPQLHPGSFAVALILLAVGGVTAAAVS
What are the official names of this protein?
UPF0719 transmembrane protein MAP_1032c.
What is the protein family that this protein belongs to?
Belongs to the UPF0719 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RARA_CANLF
Sequence: MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEAPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSEGLTLNRTQMHKAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
What is the function of this protein?
Receptor for retinoic acid.  Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.  The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5.  In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression.  On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation.  Formation of heterocomplex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (By similarity).  Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (By similarity).  RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis.  Has a role in the survival of early spermatocytes at the beginning prophase of meiosis.  In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes.  Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity).  In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (By similarity).
What are the official names of this protein?
Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Translocation to the nucleus is dependent on activation of PKC and the downstream MAPK phosphorylation (By similarity). Increased nuclear localization upon pulsatile shear stress (By similarity).