PharMolix/UniProtQA huggingface dataset:
Protein: DDL_CALBD
Sequence: MTKLKVAVLFGGVSTEHEISIVSAKSIMQNMDKEKYEVIPIGITKEGKWLLYTGKIEDLDSKWTQFSIECFVSPDRTKKALVKVKDNEATFIDIDVVFPVLHGLNGEDGTVQGLLELSGIPYVGCGVLSSAICMDKAFAKKLALLEGIPQGHFLVVYKNEYSAKKDYFIRRIESEFSYPVFVKPANSGSSVGISKAKDREDLVLAIHEAFLYDTKILIEQAINAREIECAVLGNDEVFVSEPGEIIPSREFYSYEAKYIDNSSELIIPARLPKEVTEEIKDLAGRIYKIFECCGMARVDFFVDKDTNKVYFNEVNTIPGFTSISMYPKLMEFSGIPYSQLIDKLISLAIEKNRQKKSIKYSKEG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_BDEBA
Sequence: MDDITQNLESVEKNPDIGMGRGVYISTYGCQMNVNDTERMYALLEMQNFVPVTDPKKASLIIINSCSVREKPVHKVYSEVGTYKYMKRKNPELKIGVGGCVGQQEKENLMKTQPMIDFVFGTDQIDSLPQLVAKSFAGERRLVNSRFEHRSPYHIETLVRNPGVATYVNITKGCDNFCTFCVVPYTRGREKSRPVQHILTDIRHLVKRGVKEVTLLGQNVNSYQGDEGIDFADLLAKVAKETDVERIRYTTSHPKDFNQKLVDVMAEHSNKIMEYIHLPFQAGSTKVLERMNRNYTREEYLERIAMIQKGLPNVCFSTDIIVGFPGETEEDFQDTLNMVTEVGFETIFAFSYSPRPFTKAAKFEDQLPEDVKNERLNRLFDVHEAMAFERVKRYEGTTMKVLVENVDRDHGKMQGRSTGNKLVHFLGTADLIGKTVDVKITKAFPAVFRGEMI
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM7S3_MOUSE
Sequence: MWRLRLLVLAVLAAGSAEAQANSSDGFLEFSVGKFTYFVLSKSSPQEAVLRHISSNVTFLLFQIHSQYQNTTVSFTKTLLPSTSGTGNDRGLVFILRPEQAVCTWYLETGDTKPVQSVALTLSYSERDPIPGGCNLEFDLDIDPNLYLDYNFFETTIKFAPANIGYARATEPPPCDVSTSRESRWRLRYDVYQYFLPEGDLTEASLLHHLQRMAQVAQVKASAIKVATLTADDKTAVSFSSLPGQGVIYNVIVWDPSLNTSAAYVPVHTYACSFESVDGNCASPGRVSTKVFSTLFALLGLFVCFFGHRFWKTDLFFVGFIFLGFFFYILITRLTPLQYDVRLALTAVAGSFGGLLLVASWWRFGILTLCMLCVGLVLGFLVSSGTFFTPLGNLNVFHDDGVFWVTFSCIALLVPVIFMGCLRILNILACGVVGSYSVVLAVNSYMFTSLSYITLNVLRRALNTDFRGAFIRVPFQTNDYIILAVWGMLAVSGITLQIRRERGQPPFPPHPYKLWKQERERRVTNILDPSHHIPPLRERLYGRVARIKELFQKEQPAGERTPLLL
What is the function of this protein?
Involved in the inhibition of cytokine-induced death of pancreatic beta cells (PubMed:21853325).  Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity).  Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress.  Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).
What are the official names of this protein?
Transmembrane 7 superfamily member 3, NARP1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CORA_SHIBS
Sequence: MLSAFQLENNRLTRLEVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL
What is the function of this protein?
Mediates influx of magnesium ions (By similarity).  Alternates between open and closed states.  Activated by low cytoplasmic Mg(2+) levels.  Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
What are the official names of this protein?
Magnesium transport protein CorA.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YCJV_ECOL6
Sequence: MAQLSLQHIQKIYDNQVHVVKDFNLEIADKEFIVFVGPSGCGKSTTLRMIAGLEEISGGDLLIDGKRMNDVPAKARNIAMVFQNYALYPHMTVYDNMAFGLKMQKIAREVIDERVNWAAQILGLREYLKRKPGALSGGQRQRVALGRAIVREAGVFLMDEPLSNLDAKLRVQMRAEISKLHQKLNTTMIYVTHDQTEAMTMATRIVIMKDGIVQQVGAPKTVYNQPANMFVAGFIGSPAMNFIRGTIDGNKFVTETLKLTIPEEKLAVLKTQESLHKPIVMGIRPEDIHPDAQEENNISAKISVAELTGAEFMLYTTVGGHELVVRAGALNDYHAGENITIHFDMTKCHFFDAETEIAIC
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YcjV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: CAPP_ECOHS
Sequence: MNEQYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDLYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: E2F7_DANRE
Sequence: MQEVKCLTLKDLLGVRTLVNKTGSDDAASMNDHKENICMDRRKMTPLKSESLTAALNGHGKISSPEITHITPIKLTEKAHPDPWTPTANLKMLINAASPDIRDREMKKTLFKPIENKGKIAEEEEEEELDDSCQYEALDESERRPSRKQKSLGLLCQKFLALYPDYPESSESINISLDEVATCLGVERRRIYDIVNVLESLMLVSRKAKNMYVWHGRSRLPQTLQGLLQAGRDQHYDLLMDQREGNGLHAVQHVQNAHAASSRRKDKSLRIMSQKFVMLFLVSKTQTVTLDMAAKILIEEGQEESYDSKYKTKVRRLYDIANVLTSLNLIKKIHMREEKTRKPVFKWIGPGNFQSSSNSDDLRGQISNSGTERREKMARHSSFQVITAPPVNQRLISSAPSTPHRYSTDEPVDYSRKSGNNSAVCRLQFGDGVHPSVSPAVPSALASLAMPLQADLMPVPASFSHPLAILPQTPLLMLYSGNISDGASSLRKRERSEEDDHQTTKCRRRSASIESDTVESESLSSSTRRSPVCSPEGSPWDEASFGGLHEDDVAASSSKDALLSPHYLYVPNTAGLNSFNFLLPAGHAQGGVPAVAMPYFVVQSPLIAGAMPTSSTEGAAGFSVPTVLSPAQFVMAGGAYGVTEILQSPEHHGNVPATTSSPRAEESPKPAQTQTPVTPKEASLGSKSFFETPGAFGSLVNQSAARKRGSAQRRLDIGHTAAN
What is the function of this protein?
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells.  Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'.  Directly represses transcription of classical E2F transcription factors such as e2f1.  Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes (By similarity).  Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator and promoting expression of vegfa.
What are the official names of this protein?
Transcription factor E2F7, E2F-7.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SAE2_HUMAN
Sequence: MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
What is the function of this protein?
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4.  It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
What are the official names of this protein?
SUMO-activating enzyme subunit 2, Anthracycline-associated resistance ARX, Ubiquitin-like 1-activating enzyme E1B, Ubiquitin-like modifier-activating enzyme 2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family.
Protein: TONB_KLEPN
Sequence: MTLDLPRRFPWPTLLSVAIHGAVVAGLLYTSVHQVIEQPSPTQPIEITMVAPADLEPPPAQPVVEPVVEPEPEPEPEVVPEPPKEAVVIHKPEPKPKPKPKPKPKPEKKVEQPKREVKPAAEPRPASPFENNNTAPARTAPSTSTAAAKPTVTAPSGPRAISRVQPSYPARAQALRIEGTVRVKFDVSPDGRIDNLQILSAQPANMFEREVKSAMRRWRYQQGRPGTGVTMTIKFRLNGVEIN
What is the function of this protein?
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates.  It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
What are the official names of this protein?
Protein TonB.
What is the protein family that this protein belongs to?
Belongs to the TonB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: GPAT4_BOVIN
Sequence: MFLLLPFDSLIVSLLGISLTVLFTLLLVFIIVPAVFGVSFGIRKLYMKTLLKIFAWATLRMERGAKEKNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDNTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTVLWGLGVLIRYCLLLSLRIALAFTGISLLVVGTTMVGYLPNGRFKEFLSKHVHLMCYRICVRALTAIITYHDRKNRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHLVARRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTRQAEEDAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMIVGNHEDRSRS
What is the function of this protein?
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone.  Active against both saturated and unsaturated long-chain fatty acyl-CoAs.  Protects cells against lipotoxicity.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 4, GPAT4, 1-acylglycerol-3-phosphate O-acyltransferase 6, 1-AGP acyltransferase 6, 1-AGPAT 6, Acyl-CoA:glycerol-3-phosphate acyltransferase 4, Lysophosphatidic acid acyltransferase zeta, LPAAT-zeta.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RF1_ACTP7
Sequence: MKDSIINKLESLSERHEELQALLGDPSVINDQDKFRAYSKEYSQLEEVVTTFNRWKKLNSDIEEAQILLDDPDMKEMAAEEIAENKAEIENLEQHLQILLLPKDPNDEYNAFLEIRAGTGGDEAGIFAGDLYRMYSRYCESKRWRIEEMSANESEQGGYKEIIVKISGEGVYGQLKFESGGHRVQRVPKTESQGRIHTSACTVAVMPELPESEMPEINPTDLRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVECQDERSQHKNKAKALAVLASRIVQVEQERQAAEQADTRRNLLGSGDRSDKIRTYNYPQGRVTDHRINLTVYRLDEVMNGKIDELIQPIITEYQADQLAALSEQA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_CHICK
Sequence: MGRAVSVAACALNQWALDFEGNAERILRSISIAKSKGARYRLGPELEICGYGCADHYYESDTLLHSFQVLAKLLESPATQDIICDVGMPLMHRNVRYNCRVIFLNKKILLIRPKISLANAGNYRELRWFTPWNKARHVEEYLLPRIIQEVTGQDTVPFGDAVLATKDTCLGTEICEELWAPNSPHIEMGLDGVEIFTNSSGSHHVLRKAHTRVDLVNSATAKNGGIYILSNQKGCDGDRLYYDGCAMISMNGETVAQGSQFSLDDVEVLVATLDLEDVRSYRAEISSRNLAASKVNPFPRIKVNFALSCSDDLSVPICVPIQWRHHSPEEEICLGPACWLWDYLRRSKQAGFLLPLSGGIDSSATACIVYSMCRQVCLAVKNGNSEVLADARKIVHDETYIPEDPQEFCKRVFTTCYMASENSSQDTRNRAKLLAEQIGSYHINLNIDAAVKAIVGIFSMVTGRTPRFSVYGGSRRENLALQNVQARVRMVPAYLFAQLTLWTRGMPGGLLVLGSANVDESLRGYLTKYDCSSADINPIGGISKTDLKNFIQYCIENFQLTALRSIMAAPPTAELEPLMDGQVSQTDEADMGMTYAELSIYGKLRKIAKAGPYSMFCKLINLWKEICTPREVASKVKHFFRMYSVNRHKMTTLTPSYHAENYSPDDNRFDLRPFLYNTTWSWQFRCIDNQVSHLEKKEGISVAEDTD
What is the function of this protein?
Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine-dependent NAD(+) synthetase, NAD(+) synthase [glutamine-hydrolyzing], NAD(+) synthetase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD synthetase family.
Protein: F162B_MOUSE
Sequence: MLWVSRSVLRLGLGFTTHRAPQIISRWPRWGPRVACHPCSSSGQNPSGFEPPEKVHRIPAQYKPSKFDKKILLWTGRFKSIEDIPPLVPPEMIAVSRNKARVKACYIMIGLTIVACFAVIVSAKRAVERHESLTSWNLAKKAKWREEAALAAQSKSK
What are the official names of this protein?
Protein FAM162B.
What is the protein family that this protein belongs to?
Belongs to the UPF0389 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TAL_BURP6
Sequence: MTTALDQLKQYTTVVADTGDFQQLAQYKPQDATTNPSLILKAVQKDAYRPILEKTVRDHAGESAGFIIDRLLIAFGTEILKLIPGRVSTEVDARLSFDTQRSIDKGREIIKLYEAAGVGRERVLIKLASTWEGIRAAEVLQREGIRCNMTLLFSLVQAAACAEAGAQLISPFVGRIYDWYKKQKGADWDEAQDGGANDPGVQSVRRIYTYYKHFGYRTEVMGASFRTTSQITELAGCDLLTISPELLQKLHDSTEAVARKLSPDEARDARLERVAIDESSFRFQLNDDAMATEKLAEGIRLFSADAVKLEKMIEALR
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YUAP_ECOLI
Sequence: MYFMTKKMLTFVQTPKEGLSFAMTTYLNLFVKLLIFLYIQNTKACLSINNVNNNSKNKLRSGVSYYIINLKMSMLFTEQIVTIYNKLIF
What are the official names of this protein?
Uncharacterized membrane protein YuaP.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TRPF_BACLD
Sequence: MKKPSLKYCGIHSLEDLKVTARSKADYLGFIFAESKRSVDPADVKRWCGETDTPGKKLVGVFVNENMSRMAEIVKDAGLDVIQLHGDETAADIKRLKSMTDCEIWKALPHGNDTVQSMASFAPYIDGYVIDSSVKGMRGGTGVSFSWDSVPLYIDAAQREGKRLFIAGGVNPDTIADLLKRRPPGIDLASGIEERGRKSEKLISLLEERMFEHVFISE
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: TRPD_METFK
Sequence: MSMTPKLALQRLIDHTDFTHEEMLDVMQQIMGGAFTTVQIAGFLAGLRVKGETVTEIAAAAQVMRALSSKVEVEDSSYLVDTCGTGGAPTKAFNVSTASAFVAAGAGARIAKHGGRAASSKSGSADVLEALGVNIGLTPEQVARCVNEAGIGFMFAPNHHAAMKYAAPVRRELGVRTMFNLLGPMTNPAGAKRQVMGVFDRDLVSLLAHTLKKLGSEHVMVVHSADGMDEISFSADTYVAELKHGEVNEYTLNPAQFDMPLHEIDSIHVENAQQSSEIILGVLSGARGPARDIVLLNAGAAIYVSGIAGDLQDGIAQAAHSLDSGAALHKLQQLKALSQAA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: GLYA_EXIS2
Sequence: MEQTPLTYLKQQDEELFSAMRKELKRQRDNIELIASENFVSQAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDLAENLARDRAKAIFGAEHVNVQPHSGAQANMAVYFTILNQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDPETEMIDYDVVAKLAEEHKPKLIVAGASAYPRVIDFKRFREIADSVGAYLMVDMAHIAGLVAAGLHPNPVEHAHFVTTTTHKTLRGPRGGMILCKEEHAKAIDKSIFPGIQGGPLMHVIAAKAVAFAEALAPEFKDYIEQVVANAKVLGEELTARGLRIVSGGTDNHLLLVDLQPLGITGKLAEHALDEAGITVNKNTIPFDPASPFVTSGIRIGTAAMTSRGFKEAEMKQIAELIELVLKNPEDQETLTSAHKQVLALTGRFPLYPERG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_CALS4
Sequence: MAIVIVAFVVFLDQFTKYLAAKYLMPIGSYPVIKHFFHLTYVENRGAAFGMLQNKTLFFIVITVVVGIVLIYSMIKLPENSLYNYTLAMILGGAIGNLIDRVRLGYVVDFIDFKFFPAVFNVADSFIVVGAIILGYLMIFKGGIR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL27_THEYD
Sequence: MAHKKGVGSSRNGRDSQAKRLGVKRFGGQFVKAGNILVRQRGTKFHPGANVGVGSDYTLFALIDGIVKFERKDKQRLKVSVYPVIEPAQ
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: CTK2_SCHPO
Sequence: MAENENHVLSIRMSHPYYSEKEISRILSTRDPKENNLRMQAFAWISTLSKTLKFPVRTSGLAMLLYSRFQLFFPVNEIPLLECATACLVVASKIEDTAKKFRDILLAHYLQKHPGSEVDAHSQVCYKLIEENKKRILGLERMTLELICFDFRVRHPHNYMVKFAKSLKFSSSTASIAWNVCTDAYKTYTMLKYPAHIVAVASISIACKLQQLPQPIIPRSFFAPPALTEAVIADILDLYMHYQPHTCIGNMYTTEKLLGLCVDFQRAQKNSGRPQKPPQIDPHSSSLADEYRESNKRLQESKESCARFILDCDRKYFNTEFEKRMLEERRNKGTV
What is the function of this protein?
Cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit.  As part of the CTDK-I complex, involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing.  Together with ctk3, required for ctk1/lsk1 CTD kinase activation (By similarity).  Together with ctk1/lsk1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD.
What are the official names of this protein?
CTD kinase subunit beta, CTDK-I subunit beta, CTD kinase subunit 2, Latrunculin sensitive cyclin knockout protein 1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Nuclear localization is dependent on ctk1/lsk1.
Protein: Y1967_SYNY3
Sequence: MTQSNNFATSPLWQQGSVVELTITGLNHQGEGIGRFNERVVFVPDTAPGDRLEVRLVKVKRNYALAQLLKILEPSVQRTRPSCIVADKCGGCQWQHLDYQFQVESKQQQIIDALERIGGFTTLPLEPLLQSPASLGYRNKATYPLSRSKTGQVQAGYYRKGSHRLVNINQCPVQDDRLNLLLTEVKKDIENRGWSIYDEEKKQGKLRHLSLRIGQRTGEMLLTLISAHKGLPDLEEQAGEWLERYPDLGGICLNIQPEPNNRIFGDETVVIAGRGICREKFADLSFSLGANTFFQVNSGAAELLLTRLQQALNLQGAELLVDAYAGVGTFTLPLARQVRQAIAIEVNQDSVHQGQRNAEINQIANVDFLAGTVETVLPTLSEIPDVLLLDPPRKGCAPEVLREIIRQRPEKIAYISCQPPTLARDLKFLCAEGFYGITWVQGCDFFPQTAHVECAVILKAVNG
What are the official names of this protein?
Uncharacterized RNA methyltransferase sll1967.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: ICAR_STAAS
Sequence: MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYSIDALYQFLFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLLNIFLKK
What is the function of this protein?
Represses transcription of the icaADBC operon necessary for biofilm production.
What are the official names of this protein?
Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR, Intercellular adhesion protein R.
Protein: GNT1_DEBHA
Sequence: MKLVLGNGLVNLSWEYMLSFSILLYFIFTQLIFVFEDHSLAKNLKVIPSEVINALFDNFNKNLNFDKYAYVQYATDFDYLNLAIINFIVLRRSSTKIPNLVVLFNRALQEDKNRFDGLRDLSLRYSVTLKPIPIIENVNAESPTWSKSFTKFHIFNEVKYDRIVYFDADSMLLHTQWNDNSSIVNNESNVPENLDELFTIPEIIDIALPQAYWLTKHTKASGKIKAPDGKGYQDEITALINEISKSVNDSLVFEKLPSLLVQSQKSNHRNNFFATHVMVVKPSNEIFNELKKYVHNPWLWSLHKRHALRNKSDYDMEVLNKFIDNVLQENENFKVGILPHKVYGVLTGEFRELSHESFVSEAQFLPFITGELNEQWRPIEIIRNIKLIHFSDSPIPKPWEGMNNFHFYNKFRIYCHDAGFDADLFNSLFPTSWKPRLTTDCDSVNIWNWIMAEYQKLHNELWMV
What is the function of this protein?
N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.
What are the official names of this protein?
Glucose N-acetyltransferase 1, N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GNT1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein. Vacuole membrane; Single-pass type II membrane protein.
Protein: IF2_CAMC5
Sequence: MSNVRISEIANELGYPSKEIVEKAQELGLKVKTHSNAVSLEEAEAIYEYVQSGVIPEKFKKEKPKAKPKKEAKEPSEKEVGKKQTKAKEEKPAKASTTQKKDTKSHKIGETKAKKDQESVKKQKVEVQPKQEQTKQELQPKEAEFKSEVKDEISEPQKPKESLADVSQRRRGLMIVKKKKEFESAPVRRDENRVKSTDAVEINSLKNMFASSDENLARKKKKDKKPVVATKKDSAQKMDLLGSSDFGDIVIEDEDVVVLPDFSFKTPTPQPMQKTKQPNVLKPTINNTINPFGEGGIQRRARKKHKKPENKQNSEAVTSINIPKEIRVYEFAEKLNKQPSEIIGKLFMLGMMTTKNDFLDEDAIEILADEFNVEVNIIDDQKEFDYVAAYEEEVRDDENLLPRAPVITIMGHVDHGKTSLLDYIRKSRVAAGEAGGITQHVGAYMVNKNGKNITFIDTPGHEAFTAMRARGAGVTDIVIIVVAADDGVKPQTKEAVNHAKAAGVPIIIAINKMDKEAANPDLVKTGLAELDIMPTEWGGKYEFVPISAKTGMGIDDLLEIVLLQAEILELKANPKASAKASVIESSLQKGRGPVATIIVENGTLRVGDTVVAGVAYGKIRSLLDDQGRPLQEIKPGECGVIVGLSEIAEAGETLIGVKTDKEAREYAQKKAEYLRQKELSKSTKVSLDELSAKIAEGELKTLPVIVKADVGGSLEALKASLEKLANNEIKVDIIHSGVGGITQSDVALASASKDCVILGFNIRPTGEIKEKAKESGVEIKTYNVIYNLIDDVKALLGGLMSPIIREEQLGQAQVRQVINVPKIGAIAGCLVTEGTINRGAKIRLIRDGVVVYEGMVSSLKRFKDDVKEVAKGYECGVGIEGCNDIRENDYIESFKEIEEQAKL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCP_PINMG
Sequence: MVCRFSYVQVVLILVVLSVIISWANACSCFPPDETRQQKCRRADFVFLGRGYVTGIQQIGSFFYLRYCFLIDRVFKDRASSLNIPCALTNVESSYCGVRFERGRRYIVSGYLTRSGNQIGACEWNERWSNVPFLTRLQLFNDPQWCLP
What are the official names of this protein?
NTR domain-containing protein, Prism tissue inhibitor metalloproteinase protein 2.
What are the subcellular locations of this protein?
Secreted.
Protein: RL11_WIGBR
Sequence: MTKKIKAYVKLQIKAGSANPSPPIGPALGQQGVNIIEFCKSFNAKTNKIDKDTPIPVIISVYNDRTFSFITKTPPTAFFLKQAANIKSGSDNPKNKKIGKISIFKINEIAKKKSPDMTGSTLNSISKSIIGTAKSMGLSIED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.