PharMolix/UniProtQA huggingface dataset:
Protein: XGPT_ECOL6
Sequence: MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQNTWIEQPWDMGVVFVPPISGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: METK_STRPN
Sequence: MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAETAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSPDIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRLAELRKSGEISYLRPDAKSQVTVEYDENDRPVRVDTVVISTQHDPEATNEQIHQDVIDKVIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVAADLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVAESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALKEAVK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CWP12_PHAVU
Sequence: ELPVNFYALNLTADNINIGY
What are the official names of this protein?
35 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: AAAT_BOVIN
Sequence: MVADPPKGDPKGYAAAEPTANGVSMLVPIEDVGSLKGGRCGSGDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGAFALGPARLEAFSFPGELLLRLLKMIILPLVVCSLIGGAASLDPSALGRLGAWALLFFLVTTLLASALGVGLALALQPGAAFAAINTSVGAPVEEAPSKEVLDSFLDLVRNIFPSNLVSAAFRSYTTSYKERLFNGTLVKVPTGGEVEGMNILGLVVFAIIFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPVGILFLVAGKIVEMENVGLLFASLGKYILCCLLGHAIHGLLTLPLIYFLFARKNPYRFLWGIMTPLATAFGTSSSSATLPLMMKCVEEKNGVARHISRFILPIGATVNMDGAALFQCVAAVFIAQLNHRSLDFVKIITILVTATASSVGAAGIPSGGVLTLAIILEAVNLPVHDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYLDRTENCNSVPELIQVKSEMPLAALPVPGEEGNPLLKGCPGPAGDADTCEKESVM
What is the function of this protein?
Sodium-coupled antiporter of neutral amino acids.  In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (By similarity) (PubMed:11997120).  The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation.  Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way.  Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (By similarity).  The transport cycle is usually pH-independent, with the exception of L-glutamate.  Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion.  May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (By similarity).  Can transport D-amino acids.  Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (By similarity).  Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity).  Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (By similarity).
What are the official names of this protein?
Neutral amino acid transporter B(0), ATB(0), Sodium-dependent neutral amino acid transporter type 2, Solute carrier family 1 member 5.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Melanosome.
Protein: ARL8B_MOUSE
Sequence: MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS
What is the function of this protein?
(Microbial infection) During infection, murine coronavirus (MHV) and the chaperone HSPA5/GRP78 are co-released through ARL8B-dependent lysosomal exocytic pathway for unconventional egress.
What are the official names of this protein?
ADP-ribosylation factor-like protein 8B, ADP-ribosylation factor-like protein 10C, Novel small G protein indispensable for equal chromosome segregation 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Cell projection, axon. Synapse. Cytolytic granule membrane. Note=GTP-bound form resides on lysosomal membranes, whereas GDP-bound form is likely associated with microtubular structures. Localizes with microtubules at the spindle mid-zone during mitosis (By similarity). In dendritic cells, localizes to MHC II+ compartments (PubMed:25637027).
Protein: PRMA_STRR6
Sequence: METWQELKVTVKREGEELVSNLLIELGAQGVAIEDSMDYMGNVDRFGEIFPEVEQQEEIVVTAYYPDTVDVTVVEADLQARLAELTDFMDLGEVKMGTTALAEEDWADNWKKYYEPARITHDLTIVPSWTDYEATAGEKIIKLDPGMAFGTGTHPTTKMSLFALEQVLRGGETVLDVGTGSGVLSIASSLLGAKEIFAYDLDDVAVRVAQENIELNPGMENIHVAAGDLLKGVEIEADVIVANILADILIHLTDDAYRLVKDEGYLIMSGIIKDKWDMVRESAESAGFFLETHMVQGEWNACVFKKTKDISGVIGG
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RELA_CORGL
Sequence: MSLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYDTAERLHDGVIRKSGDPYITHPLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRDFGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPRVLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRDRYLKEIIDQVTGGLRENNIAAEVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNVNNCYAAIGVVHSLFNALPGRFKDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYNAEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKEAADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTSKDQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFTASSMKTVATELHYPDVDALYTAIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSELVNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGFVTRGGGVSVHRTDCTNVEKLKEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSEDRVATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG
What is the function of this protein?
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.  This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp.  It also has (p)ppGpp-degrading activities.
What are the official names of this protein?
GTP pyrophosphokinase, (p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: GLRX3_XENTR
Sequence: MAAVLEAGSAGQFEQLIQNSAKSLTVVHFWAPWAPQCTQMNEVMAELAKEQPQVMFVKLEAEAVPEVSEKYEVTSVPTFLFFKNSQKIDRLDGAHAPELTKRVQRHASSTSFPATPNSAPKEDLNGRLKKLINAAPCMLFMKGSPQEPRCGFSRQIVALLNDQKVQFSSFDILSDEEVRQGLKTFSNWPTYPQFYVKGELVGGLDIVKEMVASGELDQMCPKAQSLEERLKALVNKAPVMLFMKGNKEMAKCGFSRQILEIMNNTGVTYETFDILEDEEVRQGLKAYSNWPTYPQLYVKGELVGGLDIIKELKESGELVSVLKGDQ
What is the function of this protein?
Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins.  Required for hemoglobin maturation.  Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
What are the official names of this protein?
Glutaredoxin-3, Thioredoxin-like protein 2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: CPFR8_XENRU
Sequence: GFASFLGKALKAALKIGANMLGGAPQQ
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Caerulein precursor fragment R8, CPF-R8.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KTRB_BACSU
Sequence: MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKPLSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMILGKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSSGLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKNRRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTPRTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKKETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVGLTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG
What is the function of this protein?
Integral membrane subunit of the KtrAB potassium uptake transporter.  The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.
What are the official names of this protein?
Ktr system potassium uptake protein B, K(+)-uptake protein KtrB.
What is the protein family that this protein belongs to?
Belongs to the TrkH potassium transport family. Ktr (TC 2.A.38.4) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: WTIP_HUMAN
Sequence: MQRSRAGADEAALLLAGLALRELEPGCGSPGRGRRGPRPGPGDEAAPALGRRGKGSGGPEAGADGLSRGERGPRRAAVPELSAQPAGSPRASLAGSDGGGGGGSARSSGISLGYDQRHGSPRSGRSDPRPGPGPPSVGSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAPFPLPALPLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSGEEGRRCYPLAGHLLCRRCHLRRLQPGPLPSPTVHVTEL
What is the function of this protein?
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration.  Positively regulates microRNA (miRNA)-mediated gene silencing.  Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1.  Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription.  Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A.  In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity).  In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.  Involved in the organization of the basal body (By similarity).  Involved in cilia growth and positioning (By similarity).
What are the official names of this protein?
Wilms tumor protein 1-interacting protein, WT1-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the zyxin/ajuba family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Nucleus. Cytoplasm, P-body. Note=Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity).
Protein: AEBP1_MOUSE
Sequence: MAPVRTASLLCGLLALLTLCPEGNPQTVLTDDEIEEFLEGFLSELETQSPPREDDVEVQPLPEPTQRPRKSKAGGKQRADVEVPPEKNKDKEKKGKKDKGPKATKPLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPSAGKKFSTVAPLETLDRLLPSPSNPSAQELPQKRDTPFPNAWQGQGEETQVEAKQPRPEPEEETEMPTLDYNDQIEKEDYEDFEYIRRQKQPRPTPSRRRLWPERPEEKTEEPEERKEVEPPLKPLLPPDYGDSYVIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEEMKKPKKEGSSPKEDTEDKWTVEKNKDHKGPRKGEELEEEWAPVEKIKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFYGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDMRQLMKAVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCQEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIISWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAEALAAARGEDDDGVSEAQETPDHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLHTNCLELSVYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNFILARSNWKRIREILAMNGNRPILRVDPSRPMTPQQRRMQQRRLQYRLRMREQMRLRRLNSTAGPATSPTPALMPPPSPTPAITLRPWEVLPTTTAGWEESETETYTEVVTEFETEYGTDLEVEEIEEEEEEEEEEMDTGLTFPLTTVETYTVNFGDF
What is the function of this protein?
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation.  May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness.  Can act as a transcriptional repressor.
What are the official names of this protein?
Adipocyte enhancer-binding protein 1, AE-binding protein 1, Aortic carboxypeptidase-like protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
[Isoform 1]: Secreted. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.
Protein: RPN1_MOUSE
Sequence: MESPVALLLLLLLCLGALAPTPGSASSEAPPLVNEDVKRTVDLSSHLAKVTAEVVLVHPGGGSTSRASSFVLALEPELESRLAHLGVQIKGEDEEDNNLEVRETKIKGKSGRFFTVKLPVALDPGSKISVVVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASRNVESYTKLGNPSRSEDVLDYGPFKDIPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIQVDSPYDISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRLGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKAVTSEIAVLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYLENEKLSSGKRQELVTKIDHILDAL
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit, Ribophorin I, RPN-I, Ribophorin-1.
What is the protein family that this protein belongs to?
Belongs to the OST1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome.
Protein: GUAA_LACDA
Sequence: MAKIDLSNFDKIIVLDFGSQYNQLITRRIRDFGIYSELLPHTITAEEVKKIAPKGIIFSGGPNSVYDENALDVDPEIFELGIPILGICYGMQLMTQKLGGTVEKAGEAEYGSAHIEVKEADSPLYKGLPEKQVVWMSHGDLVTKVPEGFEVLASSKNCPIASMADPDRKFYAVQFHAEVRNSEYGLDILRRFAFDVCGAKDNWTMDDFIKLSVDSIREEVGNANVILGISGGVDSSVTATLLHKAIGSQLTAIFVDHGLLRKNESDEVMAALKEGLGVNIVRVDAKDRFMSKLAGVTDPEKKRKIIGNEFVQVFNDEAKKIKDAKFLAQGTLYTDVIESGTDTAHTIKSHHNVGGLPEDMQFKLIEPLRQLFKDEVRVLGEKLGLPHDLVWRQPFPGPGLAIRVIGEITEEKLRIVRDADAILREEVKNAGLQESIWQYFVALPGMRSVGVMGDGRTYDYAVCIRAVTSIDGMTADFAQIPWDVLQKISVRIVNEVKQVNRVLYDVTSKPPATIEYE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RAPZ_SALCH
Sequence: MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPDLARTLADRQISAAVSIDVRNMPESPEIFEQAMNNLPGAFSPQLLFLDADRNTLIRRYSDTRRLHPLSSKNLSLESAIDKESDLLEPLRSRADLIVDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVAAFLDRHTEVHNFIYQTRSYLELWLPMLETNNRSYLTVAIGCTGGKHRSVYIAEQLADYFRSRGKNVQSRHRTLEKRKT
What is the function of this protein?
Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ.  When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E.  Consequently, GlmZ is inactivated and unable to activate GlmS synthesis.  Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
What are the official names of this protein?
RNase adapter protein RapZ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family. RapZ subfamily.
Protein: OTC_THEFY
Sequence: MAFNLRNRSFVKELDFTPQELMFLITLAADLKAAKYAGTEQPQLSGKNIALIFEKTSTRTRCAFEVAAHDQGAHVTYLDPSGSQIGHKESIKDTARVLGRMFDAIEYRGASQATVEELAEYAGVPVWNGLTDEWHPTQMLADFLTIMEHTDKPLREVTLAYMGDARNNLGNSLTVTGAMLGIDVRMVAPRELWPDEERVAAPARAIAETTGARVTFTDDIAEGLAGADFIYTDVWVSMGEPSEVWDERIRQLLPYQVNAEALKATGNPDVKFLHCLPAFHDLGTEVAREIHARTGLTALEVTDEVFESPASIVFDQAENRMHTIKALMVATLGR
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_STAAS
Sequence: MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLEHLRERLVGRGTESDEKIQSRINEARKEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_CLOBH
Sequence: MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGDLQVDSHHTVEDVGIVLGESFKKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCDFNFTVDKLGEMDTELVEEFLRALAFNAGITLHARVLYGKNNHHMIEAVFKALGRALREAVDRDEKINGVMSTKGTL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMI_ENT38
Sequence: MSVRLVLTKGREKSLLRRHPWVFSGAVARMEGKASLGETIDIVDHQGKWLARGAYSPASQIRARVWTFDKDETIDIAFFTRRLQQAQQWRDWLAKRDGLDSYRLIAGESDGMPGVTIDRFANFLVLQLLSAGAEYQRAALISALQTLYPECAIYDRSDVAVRKKEGMELTQGTVTGELPPALLPIEEHGMKLFVDIQGGHKTGYYLDQRDSRLATRQYVKDKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDVAKQNVELNKLDLSKAEFVRDDVFKLLRKYRDQGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQLLNPGGILLTFSCSGLMTTDLFQKLVADAAVDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVM
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EYA4_TAKRU
Sequence: RKLAFRYRRVKELYTTYKNNVGGLLGPAKRDAWLQLRAEVEALTDSWLTHALKSLSIISSRSNCVNVLVTTTQLIPALAKVLLYSLGAVFPIENIYSATKIGKESCFERIVSRFGTNIT
What is the function of this protein?
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph).  'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.  Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1.  Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis.  May be involved in development of the eye (By similarity).
What are the official names of this protein?
Eyes absent homolog 4.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. EYA family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MURD_ACIBT
Sequence: MLIQRGGLKVVAGLGISGVSAVNFLHEQGYQVAVTDSRPTPPGHDQIPAGVKTSFGQLDQELLLQAEEIILSPGLAPQLPEIQAAIAKGISVVGDIQLLRRATDVPIVAITGSNAKSTVTTLIGLMAKDAGKKVAVGGNLGRPALDLLKDQPELLVLELSSFQLETTSHLNAEVAVVLNMSEDHLDRHGNMLGYHQAKHRIFQGAKKVVFNRDDALSRPLVPDTTPMQSFGLNAPDLNQYGVLRDADGTLWLACGLQRLIKSSDLYIQGMHNVANALACLALGEAIGLPMESMLETLKQFKGLEHRCEYVKTVHDVRYYNDSKGTNVGATLAAIDGLGAAIEVKKGKVALILGGQGKGQDFSPLRSSIEKYAKVVVLIGEDAPVIEQAIQGATKILHAATLKEAVELCQRETQAEDVVLLSPACASFDMFKSYNDRGQQFVACVNSLV
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_PSEPG
Sequence: MARIAGVNIPDNKHTVISLTYIYGVGRTTAQKICADAGVNPAAKIKDLSDEQIETLRGEVAKFTTEGDLRRDINMKIKRLMDLGCYRGLRHRKGLPVRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.