PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_AERHH
Sequence: MIEADRLISASGGREEEVIDRAIRPKLLADYTGQDPVCEQMEIFIAAARQRGEALDHLLIFGPPGLGKTTLANIVANEMGVNIKTTSGPVLEKAGDLAALLTNLEPNDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYNVKDLTDIVARSARCLGLDMTEDGALEVARRSRGTPRIANRLLRRVRDFAQVKSDGRIDGPIAARAMDMLDVDNEGFDFMDRKLLLAVIDKFLGGPVGLDNLAAAIGEEKDTIEDVLEPYLIQQGYLQRTPRGRIATPRAYAHFGLQRPDEG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CH60_ACICA
Sequence: SAKDVKFGDSARSMMIAGVNVIAD
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_HELP2
Sequence: MNTKEPHKRLVQGKVISKFAEKSAVILVERKVVHEKYRKIVKKFKKYTIHDENNQVKVGDFVSAIECRPLSKTKSFTLKEILVVGV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RS12_BUCA5
Sequence: MATVNQLVRKPRVRKVIKSNVPALGKSPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTAYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHIVRGSLDCAGVKERKQGRSKYGVKKPKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: IFKC_DICDI
Sequence: MPPKPKQKAKQPSQQPPPPPPPAAAQLIEDILSSDEEEGGVKLPTKSSVKNALKKVKKERDRELIRQLKDQQDMELEALQAIFNDEFITMDPIIINRNMDTIIEGIKPIRESARFRITIKPYVGDDEKCFVSIYLVVGFPEKYPVVLPSIQVLVNKGLPQKKAIELEEKLIRESQGKIGNIMIFDLCEIAKDFLNENNFEPTQSIHHDFRSHQQKISIEISTNEQQQQQLQQLQQLQLQYNNDTKKEWESTLEESQLKEDRKNYRLQKSIQRAQYEKERKKTIVNEFTNGPQSKLSKQQRNIDYSIDHSINNNNNNNNNAFNNFNNNNNNNNTNNSNVSSIDNKTIDKQQTMILHLLRLLCQNDSNITNDHIKTLGEQLVQMGIFNRNHLSLLNMHNSNDNQIYQHIFQDYFLKQFNDISLSDLKNNVDSAANNSGHFLNKFWDTLNKTNENSGLKKSPSTFEYSGEGGGGGVGGGSSQKTINPHQQSRYHSDFEEIQLLGRGGFGQVVKVRNKLDGRYYAIKKIKLDSNQSLNRRILREVITLSRLHHQHVVRYYQAWIESAESLSLTNDNSDDDDDDDDEFESGSESEESQSESESESSESEESSESEESSESSESEESEESEYSDDSEFESEENNDFDQSFSEVFLFQNGNKRSLEFDLTDDSYSFLHSDCGFLLEVFDLNNKIGGNNTRSMGSSNQHLQQQQQQNQSQQQKKQPQQNQSQQQKKLKNSNSKSKSKSKSKSKSKSKSNSKKSISSSKLKNIKKSTSIPYLYIQMEYCQKILRNLTETGMNLEDDDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGDIKIGDFGLAINNKTTSTLSPTTNINSSTSSAGSLTTSSNSVQSVINTKQQQQQQQPQNYWEDEVEGQQQQQQQQQQQQQQQQQQQQQQQQHTARVGTLFYTSPEQEAGTNGDSAYDDKVDMYSLGIVFFEMWYVFSTGHERVIVLRNLREKFEFPSDFERNHSRQATLIRMLIDKDPAKRPSAQQLLQSELMPPKMEDEYIKNSIRVITNPTNQFYQTMLNSLFSQNHQHLHSHIYHHQQSSVTSSSYSKSLFCSLDLLQVKQLVDDVIITILKKHNANEMLTPQMSIIKEWNEQPNLFNNSSSSSSTTTTTSTTNTANNTNSVVINKSTSTSNINKVSNKTGKSILMDDSGQLLELRHDLRVSFKSFIETEFLNLGDHYKHHHQQQNDVRHDNSSNGNSNNNNSNDRHHDQDKSNTTTRSVDEILELLSKAPIKRYEFGHVFRKPHLVGKLPKELSQFCFDVFGSSSLYSDAETIKVTTEIFDSLPSTQNFYFVRLNHFGIVEYMWKFIGITDLTLKNEISQVVSQLIRQPWFTVKKVLLEKFKLPLKQVERIANWVLVKGTIPDVLKKLDASQNNNPLLSGNGSLGNNNNNNNNNNNVRISSSFTDLLEDIRQLAVYFEKMSISPHKVIFDLSYCFSENFYSTGIMFQVILKEEKHECLAVGGRYDSPLNLNNSNNSSSSSSSSSSNNNNSYNNYNNNNNYNYNYYSNCYLTNFNLPITGLSVAMDKVYSRERELYSQKRRQQLPPTLSSESQMIAHKFSTPDIFVISLGPNLFLERIGIVGDLCNAGFNAETMYIENPTPEEQQDASITSGALYIITIKEKGAKKTIKVKNIEKRREDDVSRDEIVKFFTLSNFNSKSRLNI
What are the official names of this protein?
Probable serine/threonine-protein kinase ifkC, Initiation factor kinase C.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Protein: RECR_RHOBA
Sequence: MSGHAGAVSDLVDQLSKLPGIGRKSAERLAFHLLRVHEDEALALASAIRRVRTDVRYCSVCYNLSETELCRICSDPKRDATRLCVVEQPRDLLSLDASGVYSGLYHVLLGRIAPLDGITPDQLTIDSLVERVRTGNFSEIIMATNPTVEGDGTSLYLSNLMQEFPVEITRLARGITSGSVLEYANREIIADALTGRQRL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: NSA1_CANAL
Sequence: MKVIVSADDTGSAKEVICNEGTDTSKQNATQPISIDNCLLEPSSSVKSRIIHFLSFNYQYLIGARLGGQVSVYELSDEESEEKFKLLHNFELPVDAQDKPVALLRVEILDSILVAFESSKVFLIHINDSFDFKPLELVLPEYKPISAFAINPQAENIVALGGKEHDLQILQLFNKNINSTVFKKNNYENEFKPQIIFKAKNVRNDHLELRVPIWITNILFAKAAKGYKLVTSTRYGQIRLYDTAEGRKPRKDYKVTEKPIVTLTFANDEQTEIIVTDTHSLIAKYSLTQVDEKAFKTISASAGEIVKPVPKLLGKFTGGNTGATFGVHAYERIVAFAGLDRYLRVFDLESREILAKVYLGVEVSALLILDDEDTEDEETKKRKRKEEEDDEELWNQLDTKKKTHTI
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein NSA1.
What is the protein family that this protein belongs to?
Belongs to the NSA1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SYW_PORGI
Sequence: METVVSGIRPTGNLHLGNYFGAIRSFLDMQHRYNCFFFIADWHSLTTHPHPDNIVRNVRTILAEYLACGIDPEKATIYVQSDVREVLELYLYLNMNAYLGELERTTSFKEKARKQPNNVNAGLLTYPTLMAADILIHRAVKVPVGKDQEQNMEMARKFARRFNTIYEVDFFPEPESFSPGATALKVPGLDGSGKMGKSEGNAIYLADDAKTISKKVMKAVTDAGPEVPNSVKPEPVENLFSMLRIVSSDEVYRHFDDLYNNCSIRYGDLKKQLAADIVAFTTPIRERILEIQADEAFLDRVVREGAERARESAARTLAEVRHIIGFR
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TP1B_LITST
Sequence: FLSAITSLLGKLL
What is the function of this protein?
Antibacterial peptide with activity against Gram-positive bacteria (MIC=6 uM against S. aureus) (PubMed:15556063).  May also show activity against Gram-negative bacteria and fungi (Probable).  Shows hemolytic activity on human erythrocytes (HC(50)=60 uM) (PubMed:15556063).
What are the official names of this protein?
Temporin-1SPb.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y04M_BPT4
Sequence: MTKRKEYMETAEKAVRELAIAYYNEHGKFPDRYSVLKSALTRSYKNMLSEVSDIIYKHKEQTGQSLDYDETFKQVLGIKE
What are the official names of this protein?
Uncharacterized 9.4 kDa protein in nrdC-mobD intergenic region.
Protein: NEP8_NEMVE
Sequence: MLRRPLLLVLFTVFSTLYAKDLRGVSPPTNESEAEVSPGDDEGPPEPGNEPDVNWRTLTIDPEDCKDKGKDCESLADEGNCLKKLNYAVGNCPWTCRFCKKENGDSKKCKDLAGERHCNGWKVKGDCVRLPDYMMQNCKLSCELCGPETRFKYTDEDVRCPEWAQAGYCSTNTDINLKCPHSCRKYKQRAPASTPYPYPVEALHPYQYRVVLPSVTILQTTTAAPSTQPAETTKAPPNTAAPTAAPTPAPTPAPAPAPTPAPVAPAPQTAPLAGSPPESTPEEQDDNSADESTEIEAGEGGGELCDEKHSSQQ
What is the function of this protein?
Probable toxin probably only used for predation.
What are the official names of this protein?
Nematocyst expressed protein 8, NEP-8, NEP8.
What is the protein family that this protein belongs to?
Belongs to the NEP3 family.
What are the subcellular locations of this protein?
Nematocyst. Secreted.
Protein: IGF1_AILFU
Sequence: MGKISSLPTQLFKCCFCDFLKVKMHIMSSSHLLYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKEVHLKNASRGSAGNKNYRM
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts.  Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.  May play a role in synapse maturation.  Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb.  Acts as a ligand for IGF1R.  Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways.  Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4.  Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.  Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).
What are the official names of this protein?
Insulin-like growth factor I, IGF-I, Somatomedin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: OPSD_SPAAU
Sequence: MNGTEGPFFYVPMVNTSGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWIMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFSIPLTIVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIMMVIAFLVCWLPYAGVAWWIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTASKTEASSVSSSSVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: DAPE_ECOHS
Sequence: MSCPVIELTQQLIRRPSLSPDDAGCQALLIERLQAIGFTVERMDFADTQNFWAWRGQGETLAFAGHTDVVPPGDADRWINPPFEPTIRDGMLFGRGAADMKGSLAAMVVAAERFVAQHPNHTGRLAFLITSDEEASAHNGTVKVVEALMARNERLDYCLVGEPSSIEVVGDVVKNGRRGSLTCNLTIHGVQGHVAYPHLADNPVHRAAPFLNELVAIEWDQGNEFFPATSMQIANIQAGTGSNNVIPGELFVQFNFRFSTELTDEMIKAQVLALLEKHQLRYTVDWWLSGQPFLTARGKLVDAVVNAVEHYNEIKPQLLTTGGTSDGRFIARMGAQVVELGPVNATIHKINECVNAADLQLLARMYQRIMEQLVA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: YCF80_PORPU
Sequence: MYCSQAITQTSRLPVSNNFYCKKTFFSSVNSNYQNLSQMQSWSSLKVLAFGLPDLHSIPVNLNNSFQEAIVISTINDNNIFADVTNSWIKMHKDKNHYSLFYKEIFKALLTKQIHVIDSPIGSKDIDNKIILIQQYIWKKGLKSPQFNSIARLNKNVDISNISTKFIMEQLSTSPVFVVKNGLNEIILGHPLSRIRRTAFNQIASSLSNLFHQPIATSPISNGLFFFHPDDAIEFKNFVQSKAPEACKDMDIKIQPVGLHVAYKMNRNFSSDIQFRFVPDFKEVGDLIFRHQQAKNLHFHENQYYGKNFFQGQPIYMIQPIIIKHRNGRISIIKFTGANDDREVVFTNLEAANKSWANFIKRTPYLKRLKKPNLLVYNLESFLKDKEVLHKADLTKFIVVTNKSAYITTKESVTLPYHNGLSKHLELNVKPKLFFVKLWIRRLLFTLTYE
What are the official names of this protein?
Uncharacterized protein ycf80, ORF450.
What is the protein family that this protein belongs to?
Belongs to the ycf80 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYA_SYNR3
Sequence: MAPAVARPRRGAEIRAAFLEFYESRGHQPIPSASLIPVDPTVLLTIAGMLPFKPVFLGQQERPAPRATSSQKCIRTNDIENVGRTARHHTFFEMLGNFSFGDYFKQQAIEWAWELSTEVFGLDPKNLVVSVFREDDEAEAIWRDVVGVNPKRIIRMDEADNFWASGPTGPCGPCSEIYYDFKPALGDEDIDLEDDSRFIEFYNLVFMQYSRDAEGTLTPLANKNIDTGLGLERMAQILQGVPNNYETDLIYPLIETAAGLAGVDYRQLDVKGQTSLKVIGDHSRAVTQLICDGVTASNLGRGYILRRLLRRVVRHGRLLGISKPFLVAMGEAAIALMQAAYPQLNERRELILAELQREEARFLETLERGEKLLADVLAAKPKQISGEQAFELYDTYGFPLELTEEIAEEHGLSVDLAGFEAAMEAQRQRAKAAAVSIDLTLQGAIEQMAADLEATAFRGYEALEHPSCVVALVVNGEPAQTASAGDAVQLVLDSTPFYGEGGGQVGDRGSLNGQDLIVSIESVNRQRDVSVHHGTIERGQLSVGDLVTAQVDPTCRRRAQAHHTATHLLQAALKQVVDSSISQAGSLVDFDRLRFDFHCPRAVTPAELEQLEALINGWITEAHSLEVQEMAIEAAKAAGAVAMFGEKYADVVRVVDVPGVSMELCGGTHVANTAEIGLFKIVSEAGVASGIRRIEAVAGPAVLAYLNERDVVVKQLSERFKVQPAEITARVAGLQEELKGATKALAAARSELAVAKAAALAAQAEAIGEHQLLVARLDGVDGGGLQSAAQGLADQLGDGAAVVLGGLPDPSDLGKVILVAAFGKAVVAKGQKAGQFIGGVAKLCGGGGGGRPNLAQAGGRDGAALDGALEQAKSSLQQELQG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F161B_HUMAN
Sequence: MTVGRPEGAPGGAEGSRQIFPPESFADTEAGEELSGDGLVLPRASKLDEFLSPEEEIDSTSDSTGSIYQNLQELKQKGRWCLLESLFQSDPESDENLSEDEEDLESFFQDKDRGMVQVQCPQALRCGSTRRCSSLNNLPSNIPRPQTQPPSGSRPPSQHRSVSSWASSITVPRPFRMTLREARKKAEWLGSPASFEQERQRAQRQGEEEAECHRQFRAQPVPAHVYLPLYQEIMERSEARRQAGIQKRKELLLSSLKPFSFLEKEEQLKEAARQRDLAATAEAKISKQKATRRIPKSILEPALGDKLQEAELFRKIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLRTANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANTLPVHITDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGLEEDFVRNKGQGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASPRKVLEELSHQSPENLVSLA
What are the official names of this protein?
Protein FAM161B.
What is the protein family that this protein belongs to?
Belongs to the FAM161 family.
Protein: LSHB_PHYMC
Sequence: PRGPLRPLCRPINATLAAQNZACPVCITFTTSICAGYCPSMVRVLPAALPPVPZPVCTYRQLRFASIRLPGCPPGVNPMVSFPVALSCHCGPCRLSSSDCGPGRAQPLACNRSPRPGL
What is the function of this protein?
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
What are the official names of this protein?
Lutropin subunit beta, Lutropin beta chain, Luteinizing hormone subunit beta, LH-B, LSH-B, LSH-beta.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: MDM12_CANAW
Sequence: MSFDINWNQLTIDDTINQSIKEFLDQQFKNISLPSFISNLAVTDFNLGEIPPEVTIRHIGDPFEEFYEDENILGAMNEANNDSKDEHLKNHGDGINKDSGYNSQNLDDEDEDDEDDDEDDEDEEEEDEDDYDDHDLGTINEGISLLNFNENSTTPSANSFAGSAAPPLPPPLNPSRDSFHSILHPYGVNSIIGATGAGSETPTNILNQNYLSSRVLPKISVKQKQPHHDDNDIQLIVEINYKGDMHINLLVNLLVNYPSPNFISLPIKLHITDIVIHSIATIAYLKKSVFLSFLCDVDDTFPDFDSNVQTPTSTTGGNFVDYYSNDATINKERIDIVKKIKIESEIGEVENNILRNVGKVEKFLVEQLRNILRDEIAWPSWICIDMNDDDDEEEEEESEDNDGGNSDLNDNDGKHGDGRTDETEAGE
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: SHE2_YEAS8
Sequence: MSKDKDIKVTPGTCELVEQILALLSRYLSSYIHVLNKFISHLRRVATLRFERTTLIKFVKKLRFYNDCVLSYNASEFINEGKNELDPEADSFDKVILPIASMFVKCVETFDLLNYYLTQSLQKEILSKTLNEDLTLTAESILAIDDTYNHFVKFSQWMIESLRIGSNLLDLEVVQFAIKCADEDGTNIGETDNIFLQEILPVNSEEEFQTLSAAWHSILDGKLSALDEEFDVVATKWHDKFGKLKN
What is the function of this protein?
RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease.  Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell.  Recruits the MYO4-SHE3 complex to the ASH1 mRNA.  Recruits also LOC1 and PUF6 to ASH1 mRNA, which are required for translational repression of this mRNA (By similarity).
What are the official names of this protein?
SWI5-dependent HO expression protein 2.
What is the protein family that this protein belongs to?
Belongs to the SHE2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm and is exported in an mRNA-dependent manner. The presence in the nucleus is essential for PUF6 and LOC1 to bind the ASH1 mRNA.
Protein: NAGB_KLEP7
Sequence: MRLIPLVTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHETRVANSRFFDGDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVIVCDEPSTMELKVKTLKYFNELEAENIKGL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: MZM1_YEAS1
Sequence: MSTRTKALNAYRHGLRATRIAFRNDAEVLLAARAKMRSGMLCPPDPKLTTEDQIQHLEDVAVFLRRNLVQGKKVDGSSTKEPRYHLNIHKDTELGDNETIADPTARVKTNLKARPFKCSDKKQ
What is the function of this protein?
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex.  Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.  Modulates the mitochondrial matrix zinc pool (By similarity).
What are the official names of this protein?
Mitochondrial zinc maintenance protein 1, mitochondrial, Altered inheritance of mitochondria protein 8, Found in mitochondrial proteome protein 36.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. MZM1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: FABV_BRAHW
Sequence: MVVEPKILNNICITAHPLGCAKEVENHINYVKSQPKVKSNVKNALILGASGGYGLASRIAIAYGLGAKTMSVSFEKGATARRTATPGWYNNEAFSAFAKKDGIEDKNLILDAFLNASKEEVIKEAKTFFNGEKIDLLIYSLAAPVRMDESTGTLYRSSLKPIGKKYNGIGVDFLTEELLEVSIDPANEDDIKSTVKVMGGEDWKLWTDALLNADLLAENAINVAYSYIGPEMTKAVYREGTIGKAKDHLEATAHELDKEMQEKIKGHAYVSVNKAVVTRSSAVIPTVPLYIGILFKVMKNKGLHEGCIEQMYRLLNEKLYNGGEVPVDSDNRIRLDDWELREDVQKEVLDSWNKLTKDNLKEIADLALFRKDYMNMHGFDEEGIDYSQDVQI
What is the function of this protein?
Involved in the fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).
What are the official names of this protein?
Trans-2-enoyl-CoA reductase [NADH], TER.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: SYA_STRA5
Sequence: MKELSSAQIRQMWLDFWKSKGHSVEPSANLVPVNDPTLLWINSGVATLKKYFDGSVIPENPRITNAQKSIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAIEWGFELLTSPEWFDFPKDKLYMTYYPDDKDSYNRWIACGVEPSHLVPIEDNFWEIGAGPSGPDTEIFFDRGEDFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPNKNIDTGAGLERLAAVMQGAKTNFETDLFMPIIREVEKLSGKTYDPDGDNMSFKVIADHIRALSFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGINETFLYKLVPTVGQIMESYYPEVLEKRDFIEKIVKREEETFARTIDAGSGHLDSLLAQLKAEGKDTLEGKDIFKLYDTYGFPVELTEELAEDAGYKIDHEGFKSAMKEQQDRARAAVVKGGSMGMQNETLAGIVEESRFEYDTYSLESSLSVIIADNERTEAVSEGQALLVFAQTPFYAEMGGQVADHGVIKNDKGDTVAEVVDVQKAPNGQPLHTVNVLASLSVGTNYTLEINKERRLAVEKNHTATHLLHAALHNVIGEHATQAGSLNEEEFLRFDFTHFEAVSNEELRHIEQEVNEQIWNDLTITTTETDVETAKEMGAMALFGEKYGKVVRVVQIGNYSVELCGGTHLNNSSEIGLFKIVKEEGIGSGTRRIIAVTGRQAFEAYRNQEDALKEIAATVKAPQLKDAAAKVQALSDSLRDLQKENVELKEKAAAAAAGDVFKDIQEAKGVRFIASQVDVADAGALRTFADNWKQKDYSDVLVLVAAIGEKVNVLVASKTKDVHAGNMIKGLAPIVAGRGGGKPDMAMAGGSDASKIAELLAAVAENL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.