PharMolix/UniProtQA huggingface dataset:
Protein: RTCA_HALS3
Sequence: MHVLDGSSGGGQLVRTALTCAAVSGESFRMRYVRRARSNPGLQAQHCAAVNAVADICDAATDGVEVGSEAFSFEPEVAAEEADDDEEPTLGGTTSVEVGTAGSIPLVFDSLLPLAGALDEPITATLTGGTDAKWAPPMDYFQHVKLPLLREHGIDATVSVDRRGFYPRGGGEATLTVEPSTPTPITLTERGDREALTAYSVAESSLADDEVAEQQATAAAPDAAHEIAYTDADSAGSAVVLAAEYEHSRAGFAALGERGVSADAVGENAADALAAFESGPGAVDSHLADQLVPVVAVAGGEVRAPEVTTHIETCVDLLAEFDYDIDIEHTDDGAVVLSA
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPQB_MYCLE
Sequence: MMRGVLVIMRLLCLGMLFTGCAGVPNSSAPQAIGTVERPVPSNLPKPTPGMDPDVLLREFFKATADPANRHLAARQFLTQSASNAWDDAGRALLIDHVVFVETRGAERVSATMRADILGSLSDMGVFETAEGVLPDPGPVELIKTSGGWRIDRLPNGVFLDWQQFQATYKRNTLYFADPTGKTVVPDPRYVAVLGHDQLATELVSKLLAGPRPEMAHAVRNLLAPPLRLRGPVTRADGSKSGIGRGYGGARIDLEKLSTTDPHSRQLLAAQIIWTLARADIRGPYVINADGAPLDDRFADGWTTSDVAATDPGVADGAGAGLHALVGGALVSLIGQNTTTVLGAFGRMGYQTGAALSRSGRQVASVVTLRRGAPDMAASLWIGDLGGEAVQSADGHSLSRPSWSLDDAVWVVVDTNNVLRAIPEPASGQPARIPVDSAAVASRFPGPITDLQLSRDGTRAAMVIGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRTDATHPVSYVNLDGVNSDAPARGLQVPLSVIAANPSTVYVAGPQGVLQYSASVAESQQGWSEVAGLTVMGAEPVLPG
What are the official names of this protein?
Lipoprotein LpqB.
What is the protein family that this protein belongs to?
Belongs to the LpqB lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PATL1_MOUSE
Sequence: MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPVAADEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPLQGPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRPPMPPRYPAPYGERISPNQLCSVPNSSLLGHPFPPNVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPSFRAFFSAPPPATPPPQQHPPGPGPHLQNLRPQAPMFRADTTHLHPQHRRLLHQRQLQSRNQHRNLNGTGDRGGHQSSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEIQGDGPKKERTKLITPQVAKLEHAYQPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDERKHKICSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMATARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVTVTSLLQQLMNLPQSASAPAPSNSHLTAVLQNKFGLSLLLILLSRGEDLQSSDPAIESTQNNQWTEVMFMATRELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR
What is the function of this protein?
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs.  Acts as a scaffold protein that connects deadenylation and decapping machinery.  Required for cytoplasmic mRNA processing body (P-body) assembly.
What are the official names of this protein?
Protein PAT1 homolog 1, PAT1-like protein 1, Protein PAT1 homolog b, Pat1b.
What is the protein family that this protein belongs to?
Belongs to the PAT1 family.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.
Protein: SYS_SYNJA
Sequence: MLDLKLLRDRPEEVRQALNKRGAVADLDRILELDGKRRQLETRRVALQAESNSLGKKVGELIRQGADPQGAEVTALRQQGADLKAEIAQLEQRERELEEEMQTLLLTLPNLPLPSVPVGQDETENVEVRRWGDALKPTHPVLPHDEVAEKLGLLEVGRAVKVAQSRFVAMVGAGAALERALIAMMLERHIAAGYTEVIPPFLVNSAALEGTGQLPKFAAESFRCADDDLWLIPTAEVPLTNLYREEVIPAERLPLYFCAYTPCFRREAGSYGRDTKGLIRLHQFQKVELVKVTHPTQSEAEHEKLVQDAEAILQMLELPYRVVELCTGDLGFSAARCFDLEVWFPSQNRYREISSCSNCWDFQARRANLRYKEAGQKGTHFVHTLNGSGLAVGRALAALLENHQQPDGSIRIPQALRPFLSSRFLSEDGALRTAP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FX1_CONMR
Sequence: MQRGAVLLGVVALLVLWPQAGAELYDVNDPDVRAMVIDGQKLMHDCAIANDYIDDPWWTLNLGAFEEKRVYHSMLSELVFCLNAFLQRRQQAP
What are the official names of this protein?
Conotoxin Mr105.
What is the protein family that this protein belongs to?
Belongs to the F superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YL415_MIMIV
Sequence: MNIVEMLCTDVIVYMMDYLSDIDKINFLKTCSSFYNHRFCVKFNDFHSFDKIRDLDYSENFKRIVFTKTKNNVKSFTLNNSYDRIPIDAKHLIIGKLFKLSLENIIPRGITHLTIEEEYGSEINPGIINPEEIPDIVTYLNIKSRNIFIKKGAIPDSVTHLYFGSDYLSKDIIPKNVVYLRFGDFSRCVIGQRLVETRQVNDITVTTTRIESYIPESVACLHLGFSMSNKCLGERIIETQEMDGEKINTTKIVSYIPKNVTCLTIFNEVYKNTFDFIPKNVTKLNLFGEIMEMIDETIIPKNITTLGLACYRDLNKIKIPKKVTRLNFLFEEYMSNPKVLDIPEHITTISLKYTHDIFKKVVFNNILNLKIDSYYFEKKLYLPNSIKTLTIYGNYDKKVIKKLPNTINTLIFKHK
What are the official names of this protein?
Putative FNIP repeat-containing protein L415.
Protein: GAR1B_MOUSE
Sequence: MMTSVPPRKSWWTSKKTVKVIRSYPTFPSLNAWEKFRGLLPVDGETNPGVGLGVEEGLLCQMVHSPEFNLFPNSVVFESNFVQVRRSRNWKEIYKASNTMALGVTSSVPCLPLPNILLMARVKWHQGQSQTWNRPSRAPSINLKSILPLKFVELQIWDDQERVLRLRTVTEKIYYLKLHPDHPETVFHFWIRLVQILHKGLSITTKDPTILVTHCLVPKSLCSPGGKTELVQKKSKGLQPSESLTHLMAQGESETLSQIFSDLHQQKQYRSEKMHINKTSSEKATPCEDSIPCTCDLNWRDAFMFGEWERENPSGPQPLSLLGTLAASSRPRLSLTGGNSI
What is the function of this protein?
RAB2B effector protein required for accurate acrosome formation and normal male fertility (PubMed:34714330).  In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation (PubMed:34714330).
What are the official names of this protein?
Golgi-associated RAB2 interactor protein 1B, Golgi-associated RAB2 interactor-like 1, GARI-L1.
What is the protein family that this protein belongs to?
Belongs to the GARIN family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: LIPA_STAAE
Sequence: MATKNEEILRKPDWLKIKLNTNENYTGLKKMMREKNLNTVCEEAKCPNIHECWGARRTATFMILGAVCTRACRFCAVKTGLPNELDLNEPERVAESVELMNLKHVVITAVARDDLRDAGSNVYAETVRKVRERNPFTTIEILPSDMGGDYDALETLMASRPDILNHNIETVRRLTPRVRARATYDRTLEFLRRSKELQPDIPTKSSIMVGLGETIEEIYETMDDLRANDVDILTIGQYLQPSRKHLKVQKYYTPLEFGKLRKVAMDKGFKHCQAGPLVRSSYHADEQVNEAAKEKQRQGEAQLNS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S100G_HORSE
Sequence: MSVKKSPEELKKIFEKYAAKEGDPDQLSKEELKLLIQNELPALLKGSSSIDDLFKELDKNGDGEVSFEEFQVLVKKISQ
What are the official names of this protein?
Protein S100-G, Calbindin-D9k, S100 calcium-binding protein G, Vitamin D-dependent calcium-binding protein, intestinal, CABP.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
Protein: Y646_HELMI
Sequence: MEKGFDKSAIQMVIITGLSGAGKSQAIRALEDLGFFCVDNLPPNLLPKFGELIVHSKGKINKIALVIDIRGGEFFDSLSDGLHQLGAQGIRCEILFLEASDEVLIRRYKESRRRHPLSGDARIFDSIQLERQMLADLRGRADKVIDTSDLSARQLKNQVFELFGKDARHSQLRITIVSFGYKYGTPRDADLLMDVRFLPNPFYEPALRNLTGNDEPVQEYVLSSPTTKVFMRKYYSLLRFLLPHYTKEGKSHLVVGIGCTGGKHRSVTLANRLAAALVDEDYAITVKHRDIDKDRGGGESA
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Helmi_06460.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: CD1E_CAVPO
Sequence: MLLLILLFFKGLVCHEKSIVGPQPLGWHHPAEAEEPLIFRLLHIASFKNHSWSHSQASAWIGDLQTHGWNSTMGTIQFLKPWSQGDFSKEELKNFEALFRLYFHDFPREVHAFAHQFQFEYPFELQISGGCKNVGKTSENFLNGAYQGSDLLSFQRSSWEPSPGAGSRAQKVCEVLSYYKDITEIVQSLLSSVCPRFLSGLIAAGKSELERQVKPEVWLSRGPSPGRGRLQLVCHVSGFHPKPVWVMWMKGQQEQKGTKTGDIPNADETWYLQATLDVAEREATGLSCRVKHSSLGGHDIIIHWGGYSILLILMYVAVIVTLVTLIVMGSWHRKQSSNRNVLSSYISNPTFPLENDTQCPRSSALQLHSAQESWIKNRILKWKRSLNQFW
What is the function of this protein?
T-cell surface glycoprotein CD1e, soluble is required for the presentation of glycolipid antigens on the cell surface.  The membrane-associated form is not active (By similarity).
What are the official names of this protein?
T-cell surface glycoprotein CD1e, membrane-associated, mCD1e.
What are the subcellular locations of this protein?
[T-cell surface glycoprotein CD1e, membrane- associated]: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells. SUBCELLULAR LOCATION: [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen.
Protein: HSAD_MYCTO
Sequence: MTATEELTFESTSRFAEVDVDGPLKLHYHEAGVGNDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKSFAGADFEAGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR
What is the function of this protein?
Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD).  Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA) (By similarity).
What are the official names of this protein?
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, HOPDA hydrolase, Meta-cleavage product hydrolase, MCP hydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. HsaD family.
Protein: URE12_STRAW
Sequence: MPEISRPAYADLFGPTTGDRIRLADTDLLIEIEEDRSGGPGLAGDEAVFGGGKVIRESMGQARATRADGTPDTVITGVVIVDHWGIVKADVGMRDGRITGIGKAGNPDTMDGVHPDLVIGPETEIIAGNGRILTAGAIDAHVHLICPQIADEALGSGITTLVGGGTGPAEGSKATTVTPGPWHLARMLEAMEEYPLNFGLLGKGNTVSHDAMLSQIRGGALGLKLHEDWGSTPAVIDAALTVADRTGVQIAIHTDTLNEAGFVGDTLAAIGGRGIHAYHTEGAGGGHAPDIMSVVSEPHVLPSSTNPTRPFTVNTAEEHLDMLMVCHHLNPAVPEDLAFAESRIRPSTIGAEDILHDLGAISIISSDAQAMGRVGEVIMRTWQTAHVMKRRRGALPGDGRADNHRVRRYVAKYTINPALAQGLAREIGSVETGKLADLVLWEPAFFGVKPHLVIKGGQIAYAQMGDANASIPTPQPILPRPMFGAIGRAPASNSFNFVAPLAIEDGLPERLSLGKRFVAIESTRGVTKADMRENDARPRVRIDPDSFAVHIDGELVEATPAAELPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha 2, Urea amidohydrolase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSC_SALNS
Sequence: MKRIAFVFSTAPHGSASGREGLDALLATSALTEALGVFFISDGVFQLLPGQKPDAVLARDYIATFKLFDLYDIDQCWICAASLRERGLENVNFVVDATPLEPVALRRELGNYDVILRF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4092_PSEA7
Sequence: MAAKVEPFWKRKTLAQLDQDEWESLCDGCGLCCLQKLEDEDDGSVYYTRIACKLLDLQTCRCTNYAERIRFVPDCIQLTPAQADEFQWLPPTCGYRLVAEGRDLPLWHHLVCGDPEQVHKERISQSGRMLSESQVAEDDWEDYLIFRAG
What are the official names of this protein?
UPF0260 protein PSPA7_4092.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: NDK_CHLTR
Sequence: MEQTLSIIKPDSVGKAHIGEIIAIFEKSGLRIAAMKMVHLSVKEAEGFYVVHKERPFFQELVDFMISGPVVVMVLQGENAVDRNRELMGATNPKEAAEGSIRALFGESIGVNAVHGSDSLENAAIEVSYFFAKTEIVNSVA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIP2_KLULA
Sequence: MVSAMWDTSALKLRNIFEEEFGGYLEKRLRESIQLNRPTKRYLKLATRSDIDLKFHKVGKKESNGSSLVKYIIEFDTTAILVKGYIRPWNNPEWKCKAPYNSNQNVDTRSLYKEKIIVRDNVKDLFSAALTKLDLSVRLNKFDQNVHAKYRLNEDFLQPLGRTLRHSCEFPVMHSRLVQRESELYEEFLSYDLPKRQMTTMDIQFKTVKVQSFQQYKIQYIQTLTREKTSQEYTSSARLPHWQSNQIQNSSIKFLKLCCEDEDFHPLELYKLENPKADQFQRKAVYRSKPIKPKWRISDEIIKRLNWNPFKELNLPKNSELLESLRDVQVRCTSYALVFKRIPSSKIDLMVSKIPVSFRSVNAISYDQFDPKSKENVQESSQCIDSLANEETTDVDEVTNKRIMTSGKRSFINADLVSIIAAKRSKLKRLSISNGDVNPVATLNETVEQSTMSNVTFQLSDKSFHNAEEKVIIFNAEYIAKNYKLINFLHQNNFCVLEMDLGDHSDILLDASTCLILRNITSVYQKQVDSFPLLRAIQELKCKYKRVVIFLSYSERSLALDSNLAYKTQLLLNCLGGTTTHLVEETQLKLTATWISLYCGTNTPNEQQIYRMSLSKEVLQHFDINPIAIESILSLTSLEEFLSISYGKRALLYGKFLTEYQLAHIDDFVTMSWSE
What is the function of this protein?
Required for initiation of meiotic chromosome synapsis.  Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis (By similarity).
What are the official names of this protein?
Protein ZIP2, Zipping up meiotic chromosomes protein 2.
What is the protein family that this protein belongs to?
Belongs to the ZIP2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=localizes to a meiosis specific chromosomal structure called the synaptonemal complex (SC) formed during meiotic prophase.
Protein: RL2_HAEIG
Sequence: MAIVKCKPTSAGRRHVVKIVNPELHKGKPYAPLLDTKSKTGGRNNYGRITTRHIGGGHKQHYRLIDFKRNKLDIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLSVGDQIQAGINSPIKVGNSLPMRNIPVGSTVHNVELKPGKGGQIARSAGAYVQIIAREGNYVTLRLRSGEMRKVLAECVATIGEVGNSEHMLRVLGKAGANRWRGIRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRHNKRTDKYIVRRRGK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: GLMS_STAAW
Sequence: MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_PONAB
Sequence: MAWRHLKKRAQDAVVILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADCLVVNVSSPNTAGLRNLQGKAELRRLLTKVLQERDGLRGVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPPRDLSTETIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFCRVTDAIGADHRR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.  Required for UMP biosynthesis via de novo pathway.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), mitochondrial, DHOdehase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: URE2_BURCH
Sequence: MIPGEILTDDGEHELNAGRATLSLVVANTGDRPVQVGSHYHFFEVNDALSFDRAAARGFRLNIAAGTAVRFEPGQTRTVELVALAGERAVYGFQGKVMGPL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHS7_USTMA
Sequence: MPAVERNAPFTKTFIRKPGQRNDTSIPLHTEAPPPLRQPTRIARAKTLTRPERSQPQVPLINPSSGGPGFSAASRSKHRFSWWTAFSLFVTFWAPSPLLSSCCGLKDKQSRQAWREKVSLVFIAILLGGFIGFITMGLNAALCPSASSHSPNTYSRIGTGGAILGVHGWAFDIAQAHHLPEAPALFSLSTSRPGSDISSLFARSTSDQSPACRGTTAAYAADASCVALNGTLLKDCPLGPLSPATFAQYGMYNQTRKIGYGWEDVESANFSNFLVLDGVVLNMSPYLKANPSPIAADVVDLAIRQQLATSPHRGRDATITFYTNPTTRNAIKCLTQKYVAGYIDKITPGCFISNLVLYCSLVVILAIVLIRFFMAVWFAWFMAGRMSSPPRPSRRRRLAPNVLPEGAMISLNSSGAAPWANKQRPPPSQPARRRRDSAQSATPSVPDSLSVHHIGDEPYVVCLVTAYSENEEGISTTLTSLSETHYSDQRKLLFVVADGMVTGSGESMSTPDVCVSLLEADPRFGTPIPMSFVSIASGKKEHNMAMVYAGHYTRATGRRTPMVVVVKCGAPEEAADSKPGNRGKRDSQMILMNFFQRVTYNDRMTPLDYDLFRKVHTLMGVTPDFFELCLMVDADTMVYPKSMKTLTNCMMRDPMIMGACGETRIANKTQSWVTMIQVYEYFISHHQAKAFESVFGGVTCLPGCFSMYRIKARKQTDDDWVPIIVKPEVTREYSQSVVTTLHQKNLLLLGEDRFLTTTLLRTFPNRKMVFCPEARCKTEVPHTFKMLLSQRRRWINSTIHNLMELVLVRDLCGTFCFSMQFVVFMDLLGTAVLPISIALTYTLVVTYCLNPPHSFTEAIPLMLLVAVIGMPALLILLATRKVVYVLWMLIYLLALPVWNFVLPVYSFWHFDDFSWGETRKVEGEAKQTGHGDEGGSATGNAVPLRRWEDWERSRLRKKKREEKRRRELERQFGSGFHNDNASDGDPDRKEAGMPLSRPGSDSFSDSVTVSDFDDDKWGNQIGGYDETLPPPVQIVRHSVWIGDQEVIIDTEDMEKMLETGWDDKAFRARNLSSASSTNALLQAQQPQYPSAVNRNRLSQMGAFATKRDAPAVPEIPARYSMYVQNNGGGRPANGHGNSNGHYEPGSYEMERTPSPGEYASLIRGGAPSPCSPGFGPAQPYGHSSAVSGGAGQYSTGSHARQRSGGANAAYNQPHQHPPQPSQPPQPPQPAQPTRPGGAPAAPPRGAGSQGSGFAGARPSNPTGRGRSYHDRFS
What is the function of this protein?
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
What are the official names of this protein?
Chitin synthase 7, Chitin-UDP acetyl-glucosaminyl transferase 7.
What is the protein family that this protein belongs to?
Belongs to the chitin synthase family. Class IV subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=A constitutive cytoplasmic pool is present that localizes to intracellular microvesicles termed chitosomes. Chitosomes constitute a separate secretory route distinct from the typical secretory pathway and serve as a vehicle for delivering the enzyme to the sites on the cell surface where polysaccharide sythesis takes place (By similarity). Localizes to septa of yeast-like cells and to the basal septum separating the living tip cell from the vacuolated part in hyphae. Also localizes to the growing bud tip in yeast-like cells and to the tip of the hyphae.
Protein: RLR07_PLAHL
Sequence: MQGVRITILWCIVLATIYAEEGPSTPRDDDPVIQKVRGLRNAGMKANDERMFKDAIEKLRHAISLLHNRVFGEERAAIKDPTVISQDAALYAQILNDYGSVLIRTKQYDEAIEVLEDSVAMIEKIYGDSHPSLGLSLRSLADAYMEKKAFKSAIKRYKTLRKHVKKGLGMTHEAYIEASLKIAEGYKKLNKKDTSRKVLKDTLKAQGGEINGLTIGIAELYMELSSAHVEVGEIDDALRAAETASAIFLQREGKDTMAYAFSLNALAGVKMQQKKVDEAIDLLDRAHNIAVSIYGENDRITLASAKTLQDVKDHKMNLLAAKDEL
What is the function of this protein?
Secreted effector that suppresses pattern-triggered immunity (PTI) in plant host.
What are the official names of this protein?
Secreted RxLR effector protein RXLR-C07.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus. Host nucleus, host nucleolus.
Protein: RPOZ_SULNB
Sequence: MRTEQLTAKAMEKVNFDKYLLANAVGKRAEKIANGAEVLLDYDTSGMKYTDIALREIAEGKITVSLEG
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: MSHR_SAGIM
Sequence: MPMQGAQRKLLGSLNSTPTATSNLGLAANHTGAPCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSSMYCFICCLALSDLLVSGSNMLETAVILLLEAGALATRTSAVQRLHNTIDVLTCSSMLCSLCFLGAIAVDRYISIFYALRYHSIVTLPRTQRVIAAIWVASVLSSTLFITYYDHAAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAHGIIRLHKRQSPAHQGFGLRGAATLTILLGIFFLCWGPFFLHLTLVVFCPQHLTCSCIFKNFKVFLTLIICNTIIDPLIYAFRSQELRRTLKEVLLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GALE_BIFL2
Sequence: MTTVLVTGGAGFIATHTDIELLNKGYDVISVDNYGNSSPVALERVEQITGKPVKRYDGDVRDEALMERVFAENNIDWVIHFAGLKAVGESVAKPIEYYDNNLYSTLVLLKVMKKHNVKKIIFSSSATVYGTPKELPITEETPTGGTTNPYGTSKLFQEQILRDVHVADPSWTIVLLRYFNPVGAHESGLLGEDPKGIPANLTPYVAKVAVGELKEVQVYGDDYDTPDGTGVRDYIHVVDLAKGHVAVIDHIDKEGVFVYNLGTGHGYSVLEVIKAYEKAAGHPIPYAIKPRRPGDIAACYADASKAEKELGWKAELTIDDMAASSLNWQTKNPNGFRDAE
What is the function of this protein?
Involved in the metabolism of galactose.  Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.  Can also epimerize UDP-GalNAc to UDP-GlcNAc.  Involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria.
What are the official names of this protein?
UDP-glucose 4-epimerase, UDP-galactose 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.