PharMolix/UniProtQA huggingface dataset:
Protein: ATPA_SHEON
Sequence: MQLNSTEISDLIKQRIEQFEVVSESRNEGTIVAVSDGIIRIHGLADVMQGEMIELPGSRFAIALNLERDSVGAVVMGPYADLAEGVKVKTTGRILEVPVGRGLLGRVVNTLGEPIDGKGAIDNDGFSPVEVIAPGVIERKSVDQPVQTGYKAVDAMIPIGRGQRELIIGDRQTGKTAMAIDAIINQRDSGIKCVYVAVGQKASTIANVVRKLEEHGALANTIVVVATASEAAALQYLAPYSGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAYPGDVFYLHSRLLERASRVNEEYVEKFTKGAVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETDLFNSGLRPAVNPGISVSRVGGAAQTKIIKKLSGGIRTALAQYRELAAFSQFASDLDDATRAQLEHGVRVTELMKQKQYAPMSVAAQAVSIFAAEKGYLKGVELKKVGDFEAALLSYMNSEHAALIKLINETGDYNADIEAELKAGLDKFVATQTW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VTP3_TTV1V
Sequence: MSYQITINNNTTSNVQNIVIADPNLASLGENVVFSDSQGPLSSLYVYDGVWVIKLRSPLSPGQSITITASSGTPNIDPTIALYYNNGSSYSNLTLVGSPTVSIVQDFGGYAISAYASGDFFLVASPTGFTPSSSRLLVVDRWATTPTSLDAVGLRLYADTNDWFGVVRKYVNGAQNVSIEQKISGTYSVVNEIDISQFAAFTDPLVMYLSINGSTANVKVYKQGSNIGTVSGNYSTTPYGNPSMAGYGTVDKHYANFIVLPYEPDPQVTVTPISSPSPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTYDITYVVFDVTPSPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTYDITYVIFDVTPSPTPTPTPTPTPTPTPTPTSTTSSNI
What are the official names of this protein?
Viral protein TPX.
Protein: NCEH1_BOVIN
Sequence: MRSSCVLLTALLALAAYYIYIPLPSSVSDPWKLMLLDATFRSAQQVSNLIHFLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSIVYIHGGGWALASAKIRYYDELCTTMAEELNAVIVSIEYRLVPKVYFPEQIHDVVHATKYFLQPEVLHKYSVDPGRVGISGDSAGGNLAAALGQQFNQDTNLKNKLKVQALIYPVLQALDFNTPSYQQNMNTPILPRYVMVKYWVDYFNGNYDFVQAMIVNNHTSLDVDEASALRARLNWTSLLPTSITKNYKPVMQTTGNSRIVQEIPQLLDARSAPLIADQEVLQHLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
What is the function of this protein?
Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity).  May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity).  Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity).
What are the official names of this protein?
Neutral cholesterol ester hydrolase 1, NCEH, Acetylalkylglycerol acetylhydrolase, 2-acetyl MAGE hydrolase, Arylacetamide deacetylase-like 1.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Microsome.
Protein: GRPE_VIBCM
Sequence: MSNEEIKNKDEQLQQDAVETEAEVVGTDADIDWNQAADEIDEKEAKIAQLEAALLVSEERVKEQQDSVLRARAEVENMRRRSEQEVDKARKFALSRFAEELLPVIDNLERAIQAADGEVEAIKPLLEGVELTHKTFVDTIAKFGLKEINPHGEVFNPEFHQAMSIQESAEHEPNTVMFVMQKGYELNGRVLRPAMVMVSK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2320_STAAT
Sequence: MLYPIFIFILAGLCEIGGGYLIWLWLREGQSSLVGLIGGAILMLYGVIATFQSFPSFGRVYAAYGGVFIIMSLIFAMVVDKQMPDKYDVIGAIICIVGVLVMLLPSRA
What are the official names of this protein?
UPF0060 membrane protein USA300HOU_2320.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOA_ARTS2
Sequence: MLIAQRPTLSEEVVSENRSRFIIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNIKNLSVSSEHDEPVVAYLRKQGPGVVTAADIAPPAGVEFHNPDLHIATLNSKGKFELELTIERGRGYVSAAQNKSGDSEIGRIPVDSIYSPVLKVTFRVEATRVEQRTDFDKLIVDVETKQAIAPRDAVASAGTTLVELFGLARELNTAAEGIEIGPSPTDAALAADMALPIEDLDLTVRSYNCLKREGIHTVGELVARSEADLMDIRNFGAKSIDEVKAKLVELGLSLKDSPPGFDLAARAAAIEEDDAAFSDDEL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: TEX51_HUMAN
Sequence: MLPLLIICLLPAIEGKNCLRCWPELSALIDYDLQILWVTPGPPTELSQNRDHLEEETAKFFTQVHQAIKTLRDDKTVLLEEIYTHKNLFTERLNKISDGLKEKDIQSTLKVTSCADCRTHFLSCNDPTFCPARNRRTSLWAVSLSSALLLAIAGDVSFTGKGRRRQ
What are the official names of this protein?
Testis-expressed protein 51.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TIM13_NEUCR
Sequence: MSDSTSETVKKAIIKQVLIESQSANARTLMEKIGENCFTSCVPKPGSSLSNSEKTCVTQCTEKYMAAWNVVNTTYLRRIQQEMGNQ
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.  The tim8-tim13 complex is non essential and only mediates the import of few proteins, while the predominant tim9-tim10 70 kDa complex is crucial and mediates the import of much more proteins.
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim13.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: KBAZ_ECOL5
Sequence: MKHLTEMVRQHKAGKTNGIYAVCSAHPLVLEAAIRYASANQTPLLIEATSNQVDQFGGYTGMTPADFRGFVCQLADSLNFPQDALILGGDHLGPNRWQNLPAAQAMANADDLIKSYVAAGFKKIHLDCSMSCQDDPIPLTDDIVAERAARLAKVAEETCREHFGEADLEYVIGTEVPVPGGAHETLSELAVTTPDAARATLEAHRHAFEKQGLNAIWPRIIALVVQPGVEFDHTNVIDYQPAKAAALSQMVENYETLIFEAHSTDYQTPQSLRQLVIDHFAILKVGPALTFALREALFSLAAIEEELVPAKACSGLRQVLENVMLDRPEYWQSHYHGDGNARRLARGYSYSDRVRYYWPDSQIDDAFAHLIRNLADSPIPLPLISQYLPLQYVKVRSGELQPTPRELIINHIQDILAQYHTACEGQ
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of KbaY.  When expressed alone, KbaZ does not show any aldolase activity.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. KbaZ subfamily.
Protein: RIMO_SALTI
Sequence: MSNVTHQPKIGFVSLGCPKNLVDSERILTELRTEGYDVVPHYDDADMVIVNTCGFIDSAVQESLEAIGEALNENGKVIVTGCLGAKEDQIREVHPKVLEITGPHSYEQVLQHVHHYVPKPKHNPFLSLVPEQGVKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPIGDVLSEAKRLVDAGVKEILVISQDTSAYGVDVKHRTGFHNGEPMKTSMVSLCEQLSKLGVWTRLHYVYPYPHVDDVIPLMAEGKILPYLDIPLQHASPRILKLMKRPGSVDRQLARIKQWREICPELTLRSTFIVGFPGETEEDFQMLLDFLKEARLDRVGCFKYSPVEGAGANELPDQVPEEVKEERWNRFMQLQQQISAERLQEKVGREILVIVDEVDEEGAIGRSMADAPEIDGAVYLNGETNVKPGDIVRVKVENADEYDLWGSRV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCC2_DANRE
Sequence: MPRKKVTDVSGNGGLKRKRGGGKKKEREFSSDDEFDDYEQENTKKPGKPAAKAGLQPVTVADDVKEKIKLEVPKVKGQLLIFGATNWDLIGRKEVPKQQAAFRNLGQNLWGPHRYGCLSDVQVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQYNGQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYCGYQCSFALSEMGGLFFWGVTNTSRESTMYPKAVQDLCGWKIRSLACGKSSIIVAADDSTISWGPSPTFGELGYGDNKPKSSTTAQEVKTLDGVYSEQVVMGYSHSLVIARQDTEQEKEKLKKLPEYNPRTL
What is the function of this protein?
Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA.  Required for normal progress through the cell cycle, both during interphase and during mitosis.  Required for normal attachment of kinetochores to mitotic spindles.  Required for normal organization of the microtubule cytoskeleton in interphase cells.  Interferes with the activation of RAC1 by guanine nucleotide exchange factors.  Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (By similarity).  Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration (PubMed:25074804).
What are the official names of this protein?
Protein RCC2 homolog.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome. Midbody. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CYB_PTEBR
Sequence: MTNIRKTHPLIKIINNSFIDLPTPSNISAWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWIIRYMHANGASMFFICLFLHVGRGLYYGSYMFYETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFAIAALATIHLLFLHETGSNNPSGIPSDSDKIPFHPYYTIKDIMGTMFLILMLMALALFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLVIIPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFIIIGQLASILYFVILLILMPTISIIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LHDAG_HDVV2
Sequence: MSQSDXRSGXKAREEALEQWVEERKKKRIAEKELRRINKKIKKLEDENPWLGNVVGMLRKKKDEEGGPPAKRARREDMEIDSTPGRKSKARGFTDQERRDHRRRKALENKKKQLAGGGKNLSXEEEEELRRLARDDDERERRVAGPRPGGVNPMXGPPRGAPGGGFVPSLQGVPESPFSRTGEGIDIRGTQQFPWYGFTPPPPGYYWVPGCTQQ
What is the function of this protein?
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal.  Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding.  Packages the HDV ribonucleoprotein in hepatitis B virus empty particles.  Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg.  May inhibit viral RNA replication (By similarity).
What are the official names of this protein?
Large delta antigen, L-HDAg, p27.
What is the protein family that this protein belongs to?
Belongs to the hepatitis delta antigen family.
What are the subcellular locations of this protein?
Virion. Host nucleus, host nucleolus. Note=isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place (By similarity).
Protein: RL17_ACHLI
Sequence: MAIPSRLRRTTDQREALLRDLVTDLIINDRITTTEAKAKSVQRVADKMVTLAKKGTLAARRQAAETVRLEDAGEGKDALQKLFSVIAPRYNDRTGGYTRIIKTVPRRGDAAPMAIIEFI
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RS15_EHRCR
Sequence: MSITRERKSELISEYCLKKDDTGSSFVQCAILSERIRNLTEHLKVHKKDFHCRRGLMVLVCRRRNVLQYVRKKYGDSEYLALIKRLGIRDIFH
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: LEUC_NATPD
Sequence: MSEGTLYDKVWENHKVTTLPNGQDQLFVGLHLIHEVTSPQAFGMLRERDIEVARPDLTHATVDHIVPTADQSRPLDNEAAEEMMAELEENVREAGITLDDPTTGNQGIVHVIGPEQGLTQPGKTIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATQTIAMEKKDVRKIEVTGELGEGVTAKDIILTIIRRLGTDGGVGYVYEYAGEAIENLGMEGRMSICNMSIEGGARAGYVNPDETTYEWLRETDAFADDPERFEELKPYWESVRSDPDAEYDDVVTIDGSEIEPVVTWGTTPGQGIGITEEIPAPEDLPADKQDTARRAQDHMGVEPGETMAGYNIDVAFLGSCTNARLPDLRSAAEIIKGREVHDSVRAMVVPGSQRVKAAAEDEGLDSVFKEAGFDWREAGCSMCLGMNDDQLVGDEACASSSNRNFVGRQGSKDGRTVLMSPEMVAAAAVTGEVTDVRELPKAEVEA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: GUNA_CELFI
Sequence: MSTRRTAAALLAAAAVAVGGLTALTTTAAQAAPGCRVDYAVTNQWPGGFGANVTITNLGDPVSSWKLDWTYTAGQRIQQLWNGTASTNGGQVSVTSLPWNGSIPTGGTASFGFNGSWAGSNPTPASFSLNGTTCTGTVPTTSPTPTPTPTTPTPTPTPTPTPTPTVTPQPTSGFYVDPTTQGYRAWQAASGTDKALLEKIALTPQAYWVGNWADASHAQAEVADYTGRAVAAGKTPMLVVYAIPGRDCGSHSGGGVSESEYARWVDTVAQGIKGNPIVILEPDALAQLGDCSGQGDRVGFLKYAAKSLTLKGARVYIDAGHAKWLSVDTPVNRLNQVGFEYAVGFALNTSNYQTTADSKAYGQQISQRLGGKKFVIDTSRNGNGSNGEWCNPRGRALGERPVAVNDGSGLDALLWVKLPGESDGACNGGPAAGQWWQEIALEMARNARW
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Endoglucanase A, Cellulase A, Endo-1,4-beta-glucanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 6 (cellulase B) family.
Protein: ATG2_KLULA
Sequence: MSSWLPQNVQKRLLLYVLQQVSLFSNVDLTNLDVSLGSQSQFSFNDIDLNVKEIKLPNVDVLSGKIEKLNLQLAVAGNVDISGEGLTFVLKPIDRFFEDDLSDQWASSLTKSVIDMTKSIMESDVTDSSEHSVEALEEVSKSPTALDSMRNKVLQMALGKLSLKMKRIEFQFLLSTEVTLKFTIDTITLLTVDNKRTVDMGGIEVAFSKTQLSPTNSHQNTDSDVEENENTDSEDAMTASITYSKLEATSIYLSAMESLILESSDDAVQVVLTIDKVNIQFQGVTSINDLKVRDVIIRIDEINIYLRKISPIRKHLLSILRASLDKTSSDGTRTENMRNYKRFQQEQNIKEEEVLTAILLKKVSLHLLDDLELNLIDISLKKSEGFTTSASVFDLKLLYMSNEYFFSSPSAQPLFSMQPDQTTAEKKMFLNRDITLNVDSVLLNELLKLVEEYGSAYNYIQKITRASANQKTAEVLHFKSQSINLKILMNNISLELSMDPIKSTLPHTLFDVEKISLLLIRGDKKVLIGTLSNLIISSKTNGCFHVESFDHKFGAIDINTRTKAVLESLHLFLSQAELELISSNLIAFCGSISSFTNPNTRNNGHENVTKKSVRLLHSSNVMNKRATLSNFVLQVHKAKMTITNTLENTFGDITIEAISCILSQDQNKTLCGIVKEARLQRLYMREKTDIICNVNHDRSKPQLILNMPNSGKPKLYLKGLGLFIDSKWRDLVPSSSKGDIKQERKLTFRTMEVRLYDCSLSLKPYRICTGMVISIPKSIINFSPLGITVSLRSLETLLIDDMKVLKERNTKVLENISLSTWYQKQGYSPLIKVDVLSLHFSNTDSMAVSLKVQKVDVSVCSDSLNALMQTALDLKPAETYPDTLKYQIEPEAVDIFNELCEDFFVTKENPNDKTEDDYETPPVSQGSVNFEEEHFSTERRTVVENDSKSSVFSILTTIKIHIEEVKLKLYDGYEWRHTRKEIKSAVDRIQEDFNDGLELSETKVFDSIYIPAPKDTVENIKDNINRKIHNEETNEGKMKLRPTKKYKVLIKGRDLCIEFKGGQDKIAERASSLSSINDYCILNNTFVKVSDLEIIDNLPTSTWNKFLTRSRSNDKMAQEPAMLVIECSLIRPVPHLYATELICNINIVPLTLHVDQDTLEFLTLFFQFKDNRFELLDEYPDILYIQRLEINSVRLLLDYKPKKVDYAGLKSGKTKEFMNFFILDEARIKLKHVILYGVNGFPQLETILSDIWTPDITKTQIPGILSALTPLKPLAGLSYGARALISVPTEHYQQNGRFGGSLQNGGMVFLKTTGGEVIKLAVRLTSGTQTILENTEKLLGGQGITGRNVPITLVEGDEKVDALIDESLLRSTALFNKEPDNKSNHLDVLLADGNHQKVLSLYADQPKDFNSGLQDAYESMERNLYLTFDSMKKAKKELKTAKGAQEAVSTVAKAAPFVLIRPLIGVTEALSKTLQGLNNQYDEDRIAQIEEKYKSKKQNNNQ
What is the function of this protein?
Lipid transfer protein required for autophagosome completion and peroxisome degradation.  Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion.  ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region.  The latter binding is assisted by an ATG18-PtdIns3P interaction.  ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
What are the official names of this protein?
Autophagy-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATG2 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: RS14Z_LISIN
Sequence: MAKKSMIAKQKRTPKYAVQAYTRCERCGRPHSVIRKFKLCRICFRELAYKGQIPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: PYRE_PASMU
Sequence: MEAYKSEFIQFALSRQVLKFGEFTLKSGRISPYFFNAGLFNTGADLARLGEFYAKAIQASGVEYDVIFGPAYKGLPIATTVSVALFNHFQIDKPVCFNRKEAKDHGEGGQLIGYGLSGKILLVDDVITAGTAIRESMTLIAQNQAELSAVMIALNRQEKGKGELSAIQEVERDYQCQVLSIVNFDDLMTFIEQAPEYQQYLPAMRAYREQYGVK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: MIAE_PSEPK
Sequence: MSLIPEIDAFLGCPTPDAWIEAALADQETLLIDHKNCEFKAASTALSLIAKYNTHLDLINMMSRLAREELVHHEQVLRLMKRRGVPLRPVSAGRYASGLRRLVRAHEPVKLVDTLVVGAFIEARSCERFAALVPHLDEELGRFYHGLLKSEARHYQGYLKLAHNYGDEADIARCVELVRAAEMELIQSPDQELRFHSGIPQALAA
What is the function of this protein?
Involved in specific tRNA modification.  Catalyzes the oxygen-dependent hydroxylation of 2-methylthio-N-6-isopentenyl adenosine (ms2i6A) to produce 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A) at position 37 in tRNAs.
What are the official names of this protein?
tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase, 2-methylthio-N6-isopentenyladenosine(37)-tRNA monooxygenase, tRNA-(ms[2]io[6]A37)-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the MiaE family.
Protein: TSAD_CUPMC
Sequence: MLVLGIESSCDETGLALYDTEAGLLAHALHSQIAMHREYGGVVPELASRDHIRRVLPLLQQVLDDAGRTRADIDAIAYTQGPGLAGALLVGASVANALGFALGVPMIGVHHLEGHLLSPLLTSAPPPFPFVALLVSGGHTQLMEVKGIGDYKLLGETLDDAAGEAFDKTAKLLGLGYPGGPEVSRLAEFGNPGAFELPRPMLHSGNLDFSFAGLKTAVLTQTRKLSNACEQDRANLARAFVDAIVDVLAAKSFAALKQTGDKRLVVAGGVGANRQLRERLNEMGKRRKVEVFYPDLAFCTDNGAMIAFAGAMRLKAAPELARHGYDYGVTPRWDLADIRLPEARTS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_PEDPA
Sequence: MRLMGMDVGSRTVGISVSDQLGWTAQGVEIVPINEDEEIFGIERVKELVKEYDVVGFVLGLPKNMNNTEGPRVEAARNYGKLLEETFGLPIDFQDERLTTVEAERMLIEQADTSRSKRKKVIDKLAASLILENYLNGHGKLIDRLK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRIT_STRCO
Sequence: MVRDWSACGSLLLVMTVAKDRGGPAVAGSGGGVESPELRAAYEVCEAEARQFAVELWAAAETLPVETRPSLYAIASWSAYTDRIIDEGPLEGREERLAQWSADTLADLRAGHSSHPLRRALVDTVRRWGLAEALIEEHLDSARADCAAVPVFETFKDQRRYLRGCSGALAELWVPLLEPRGPEAFRLMSVLGEACQVADLFEDLPDDLAAGRCYLPRQDLRGLGLDVDDLRRGEREEALNAFVDAQLAHWRGLLEETVLAPSTVGARYQIFVHTLLLGAQMHFDEVTLLRSRVLTQGLESLVTGDGRMSRRAARPGPGPVPGHIAVIADGNRRWAEARGLLADQGHRAGIRAVLRLVNAAQRTGIRHVTVYMFSTENWYRSQGEVAALFGAFADWFARGAQTVHELGVRVRWSGRRDRLEESLASSFELLESMTANNDKLTLTICLDYGGREELAAAARALAAEAVAGTIRPEQIGMAEVARHLYVPEMPDVDLLVRTCEQRISNFLPWHLAYAELVFDPAPWPDFDLARLRDAVDSYAGRERRFGGDAELPAQAGNLEPARNG
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Bifunctional protein CrtB/UppS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UPP synthase family.
Protein: RNH_CHESB
Sequence: MKRIEIFTDGACSGNPGPGGWGAILRYNGTEKELYGGEADTTNNRMELTAAIEALEALKEPCEVDLHTDSNYLRDGISGWIEGWKRNGWRTADRKPVKNAELWQALDEARRRHKVHWHWVRGHAGHPENERADALARAGMAPFKKKKGGDTASSEEGSARRR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YADN_ECOLI
Sequence: MSKKLGFALSGLMLAMVAGTASADMDGGQLNISGLVVDNTCETRVDGGNKDGLILLQTATVGEIDAGVLNDTVGAKAKPFSITVDCSKANPNPGSTAKMTFGSVFFGNSKGTLNNDMSINNPSDGVNIALHNIDGSTIKQVQINNPGDVYTKALDATTKSAVYDFKASYVRAVADQTATAGYVKTNTAYTITYQ
What is the function of this protein?
Part of the yadCKLM-htrE-yadVN fimbrial operon.  Could contribute to adhesion to various surfaces in specific environmental niches.
What are the official names of this protein?
Uncharacterized fimbrial-like protein YadN.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium.