PharMolix/UniProtQA huggingface dataset:
Protein: ERCC1_BOVIN
Sequence: MDEEGVHKPAGPPTRKKFLIPTDEDVVPPPGAKPLFRSTRSLPTVETSPPPGPQTYAEYALSGPPGGAEATRPVGPEPLAEETPNQAPKPGAKSNSIIVSPRQRGNPVLRFVRNVPWEFGDVLPDYVLGQSTCALFLSLRYHNLHPDYIHQRLQSLGKSYALRVLLVQVDVKDPQQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEKLEQDFVSRVTECLTTVKSVNKTDSQTLLTTFGSLEQLIAASREDLSLCPGLGPQKARRLFDVFHEPFLKVPH
What is the function of this protein?
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair.  Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL).  Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure.  Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity).
What are the official names of this protein?
DNA excision repair protein ERCC-1.
What is the protein family that this protein belongs to?
Belongs to the ERCC1/RAD10/SWI10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MCA1_PLABA
Sequence: MSLQMDKIYVKVHELKFVNNLERNSHYVKIYWDDKKYKSQTKDGGCYIFNETFLIPITNIYDQKDQIIYVEIWESNLLNKQCAYTFFTLNSIKIGQIIKENITFIEVLKKCTLGLSINIVRNQKDILFFNIKELLPTFQDQEIINAVWKNEDEASIIKQLINLNTIDGITNIGNYKNSQNYNETLQKPKENISIYKSGEEIENSYIPSSTPEYVSHYIYKGAGENSSNYINKTKDTLFPTYLNNYAYNNNIKNVYDTPNGAHYSSNNNSGSNNAYSNFDHNINNSPKNNVPFSNSDNDKIFHYSRNYMPSPNSEKMLYFSCGNKKKALLIGIDYCGTQNELKGSINDAIITNELLIKKYNFYDSSMNILKLIDNQTNPNYRPTKRNILSALEWLVQDNNPGDIFFFFYSGHSYKKYDYTCIEKGGYNQTIVPCDFKTEGEIIDNDLHKYLIQPLKDGVKLVSFIDCPNSEGILNLGYKYKLKKEKWKETYNPFHVLADVTQFSYSKINEFPTEINLLEHVLITNNIEALTYHYMIQSIHSYINLYNKKKKKKIFLMSSQKFNIDRKFDFNHILKNSNSELGQQKNIIKWKKNKKK
What is the function of this protein?
Cysteine protease that cleaves specifically after arginine or lysine residues.
What are the official names of this protein?
Metacaspase-1, PfMC1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
Protein: KATG_SYNP6
Sequence: MTATQGKCPVMHGGATTVNISTAEWWPKALNLDILSQHDRKTNPMGPDFNYQEEVKKLDVAALKQDLQALMTDSQDWWPADWGHYGGLMIRLTWHAAGTYRIADGRGGAGTGNQRFAPLNSWPDNTNLDKARRLLWPIKQKYGNKLSWADLIAYAGTIAYESMGLKTFGFAFGREDIWHPEKDIYWGPEKEWVPPSTNPNSRYTGDRELENPLAAVTMGLIYVNPEGVDGNPDPLKTAHDVRVTFARMAMNDEETVALTAGGHTVGKCHGNGNAALLGPEPEGADVEDQGLGWINKTQSGIGRNAVTSGLEGAWTPHPTQWDNGYFRMLLNYDWELKKSPAGAWQWEPINPREEDLPVDVEDPSIRRNLVMTDADMAMKMDPEYRKISERFYQDPAYFADVFARAWFKLTHRDMGPKARYIGPDVPQEDLIWQDPIPAGNRNYDVQAVKDRIAASGLSISELVSTAWDSARTYRNSDKRGGANGARIRLAPQKDWEGNEPDRLAKVLAVLEGIAAATGASVADVIVLAGNVGVEQAARAAGVEIVLPFAPGRGDATAEQTDTESFAVLEPIHDGYRNWLKQDYAATPEELLLDRTQLLGLTAPEMTVLIGGLRVLGTNHGGTKHGVFTDREGVLTNDFFVNLTDMNYLWKPAGKNLYEICDRKTNQVKWTATRVDLVFGSNSILRAYSELYAQDDNKEKFVRDFVAAWTKVMNADRFDLD
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: NDK_BRASB
Sequence: MAIERTFSIIKPDATERNLTGAINALIEKAGLRIVAQKRIRMTREQAETFYAVHKARPFFGELVDFMISGPVVVQVLEGEGAILKYRDVMGATDPSKAADGTIRKLHAKSIGENSVHGSDAAETAAIEIAQFFSGNEIVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFP1_TRIV3
Sequence: MSTEAPVLGILCGGGPAPGLNGVIAGATLYALRLGWKVIGFMEGFKYLCTGDVDVVKAHTIDLTYDIVSRIHFQGGTIIQTSRANPRKSPELQENVRKCLRALKVRYFLTIGGDDTASSAVSVASGMNGNEISVISCPKTIDNDLPLPADQSTFGFHTARSLGMEIIRNLMVDSKSAPRWFLVEAMGRSAGHLALGMAEASGAHLCLIPEEFKQDEIEFEDVVELVEATILKRLAYGKNYGVCVLAEGLVSKMSKKALYKLFGNREPPTDPHGHILLDDAELARSLSEELLKRLGNLGIRITPKKIGYELRCADPVAFDAVYTRELGYGAIDAFLNGHSAALIVRENGQVKPVQFKDLLDPATGRVRTRLVDVTSQSFKVARVYMWRMSKKDYENKDLVARVAAAGKMTPEAFTEKFAHLTDVVVE
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis.  Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.  Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
What are the official names of this protein?
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase 1, 6-phosphofructokinase, pyrophosphate dependent 1, PPi-dependent phosphofructokinase 1, PPi-PFK 1, Pyrophosphate-dependent 6-phosphofructose-1-kinase 1.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Short' sub-subfamily.
Protein: RFRNP_NITOC
Sequence: MERFILDTSVFTNPDTFNQFARDAVEATRIFLQLARRADAEFFIPGSVYEEFRLMKDLASLGGDFESVVKIRSPRRYSLTIPSEFLYELIHEVRHRIDRGLRIAEEHARMAAQPGTVADQGALITRLRERYRETLRRGIVDSREDIDVLLLAYELDGVLLSADEGLRKWADKVGVKIILPQHLRRVLENLTSCSRPQK
What is the function of this protein?
RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.
What are the official names of this protein?
RNA-free ribonuclease P, RNA-free RNase P, Protein-only RNase P.
What is the protein family that this protein belongs to?
Belongs to the HARP family.
Protein: PTF2_SCHPO
Sequence: MDEIQESSCNEKLSDEDLAAEFVEFTDNIPIEIYRSLRYIRKYENFFAKENENLNTAARLVCDCPISEVPSAKQKLADSLFTSHEYLRQTSAEANKLYENVLASYKHLCEKIKYLEADNPLYVPAP
What is the function of this protein?
Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.
What are the official names of this protein?
Pdp3-interacting factor 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CDKF1_ARATH
Sequence: MDKQPATSWSIHTRPEIIAKYEIFERVGSGAYADVYRARRLSDGLIVALKEIFDYQSAFREIDALTILNGSPNVVVMHEYFWREEENAVLVLEFLRSDLAAVIRDGKRKKKVEGGDGFSVGEIKRWMIQILTGVDACHRNLIVHRDLKPGNMLISDDGVLKLADFGQARILMEHDIVASDENQQAYKLEDKDGETSEPPEVIPDYENSPRQGSDGQEREAMSKDEYFRQVEELKAKQVVRDDTDKDSNVHDGDISCLATCTVSEMDDDLGRNSFSYDADEAVDDTQGLMTSCVGTRWFRPPELLYGSTMYGLEVDLWSLGCVFAELLSLEPLFPGISDIDQISRVTNVLGNLNEEVWPGCVDLPDYKSISFAKVESPLGIEGCLPNHSGDVISLLKKLICYDPASRATTMEMLNDKYLSEEPLPVPVSELYVPPTMSGPDEDSPRKWNDYREMDSDSDFDGFGPMNVKPTSSGFTIEFP
What is the function of this protein?
CDK-activating kinase that modulates CDKD-2 and CDKD-3 activities by phosphorylation of the T-loop.  Activates CDKD-2 C-terminal domain (CTD) kinase activity.  Activates CDKA-1 probably by phosphorylation.  Posseses a CDK kinase activity independently of association with cyclin CYCH1-1.  Phosphorylates the CTD of the large subunit of RNA polymerase II.
What are the official names of this protein?
Cyclin-dependent kinase F-1, CDKF;1, CDK-activating kinase 1-At, CAK1-At.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: NUOI_RICCN
Sequence: MINYLKSFFLYEIVRGMVLTLKYFFKPKVTINYPYEKSPISPRFKGEHALRRYENGEERCIACKLCEAICPAQAIVIEADEREDGSRRTTRYDIDMTKCIYCGLCQEACPVDAIVEGPNFEFASLTHTALIYDKERLLQNGDRWEQALASKLHKDYEYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VPS29_ARATH
Sequence: MVLVLALGDLHVPHRAADLPPKFKSMLVPGKIQHIICTGNLCIKEIHDYLKTICPDLHIVRGEFDEDARYPENKTLTIGQFKLGLCHGHQVIPWGDLDSLAMLQRQLGVDILVTGHTHQFTAYKHEGGVVINPGSATGAYSSINQDVNPSFVLMDIDGFRAVVYVYELIDGEVKVDKIEFKKPPTTSSGP
What is the function of this protein?
Plays a role in vesicular protein sorting.  Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.  Required for the auxin-carrier protein PIN2 sorting to the lytic vacuolar pathway and the PIN1 recycling to the plasma membrane, thus influencing auxin transport orientation (PubMed:29897620).  Also involved in the efficient sorting of seed storage proteins globulin 12S and albumin 2S.  The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 29, Protein MAIGO 1, Vesicle protein sorting 29.
What is the protein family that this protein belongs to?
Belongs to the VPS29 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NUON_SERP5
Sequence: MTITPQQLIALLPLLIVGLTVVVVMLGIAWRRDHFINATLTVIGLNLALLSLYFVGQAGPMDVTPLLRVDGYSMFYTGLVILASLATCTFAYPWLVGYPDNREEFYLLVLIATLGGILLASANHLASLFLGIELISLPLFGLVGYAYRQKRPLEAAIKYMLLSAAASSFLLFGMALLYAESGDLSLAGLGKSLQENMMHQPLVLAGMGMMIVGLGFKLSLVPFQLWTPDVYQGAPAPVSTFLATASKIAIFAVVMRLFLYAPAADNEALRMVLSIIAVCSILFGNLMAISQTNIKRLLGYSSIAHLGYLLVALIAVQTHQLSLETAGVYLAGYLFSSLGAFGVVSLMSSPYRGPDADSLFSYRGLFWHKPILSAVMTVMMLSLAGIPMTLGFIGKFFVIAMGVSAHLWWLTGAVVLGSAIGLYYYLRVTVSLFLSAPEALQRDTPNNWALTAGGVVVLISAALVLLLGVYPQPLITLVQMAQPMF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMH_ALIB4
Sequence: MDIPHIPVLYNEVLETFKDINEGYIIDCTTGFAGHSSGLLNQNQNIKLICNDQDDEALAFSKKRLEKFENGVIFNKGNFEHVIETFKDYEIRGVLADIGVSSLQLDKLERGFGFESLTLDMRMNQNQSLDAATVVNTYSQTELERIFKDYGEVREYKKVASLIVNNRPFNSSKELADFLSKKMSKGKLHPATLPFQAIRIEVNDELGVLERLFDSLEKAKLKDCIVAIISFHSLEDRIVKNYFKKWSKSCICPDNVFRCECGNNHALGKIITKKPIIPTALEIKQNPRSRSSKLRVFKFD
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_XYLFT
Sequence: MKLINAYTDGSCLGNPGPGGWAVLLRYKNNEKELVGGELDTTNNRMELMAAIMALERLSEPCQIKLHTDSQYVRQGITEWMSGWVRRGWKTAAGDPVKNRDLWERLCAATQRHMIEWCWVKAHNGDSDNERVDVLARGQAMAQRSTVASR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HI, RNase HI.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_THEON
Sequence: MAKRVHIFDWHKKNAKKVEEFAGWEMPIWYSSIKDEHLAVRNGVAIFDVSHMGEFIFKGKDALEFLQYVTTNDISKPPAISGTYTLVLNERGAVKDETLVFNMGNDTYMMVCDSDAFEKLEAWFNAIKRGIEKFGELDLEIENKTYDMAMFSIQGPKARDLAKDLFDIDINDLWWFQAKEVELDGIKMLLSRSGYTGENGFEVYFEDANPYHPDPERRGEPEKALHVWKTILEAGEKYGIKPAGLGARDTLRLEAGYTLYGNETKELQLLSTDIDEVTPLQANLDFAIFWDKEFIGKEALLKQRERGIPRKLVHFKMIDKGIPREGYKVYANGELIGEVTSGTSSPLLGIGIGIAFVKTEYAKPGVEIEVEIRGKPKKAVTVAPPFYDPKKYGAFREE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Probable aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: ZBTB4_MOUSE
Sequence: MPPPAEVTDPSHAPAVLHQLNEQRLRGLFCDVTLIAGDTKFPAHRSVLAASSPFFREALLASAPLPLPPVTGGSAPSPATTTAASSSSSSPPPASPHSSSPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGEGGDTWVPPAPTSMVTSDPTEDGLGAGPRTDGEWVGDKAEALTPDSQPRRPFPCPRCGKSFIHPKRLQTHEAQCRRGSNTRGSAGLGPGVSGSGGPAGVDASALPQPVGFRDGPEHVVKVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWDTFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPRLNTLKLYRLLPMRAAKRPYKTYSQGAPEAPLSPSLHTPAPAAMPASPQPLPPPAPEPGPPPSVITFAHPAPSVIVHGSSSSGAAGGGPAGTGGSQAASVITYTTPPRPPKKREYPPPPPEPTATPTSPASTAVSPATAAGPATATEEAKGRNLRAGRTLTYTAKPVGGLSGSGGSPTGTGRGSSQLQAPPPLCQITVRIGEEAIVKRRISETDLRPGELSGEEVEESEEEEEEEEEEDQEEQEESKAGGEDQLWRPYYSYKPKRKAGATAGGASGVSGLPRGRRPPRWRQKLERRGWEETPSVEGPGGRGRGERRHRCGDCAQAFATVRKLRKHQEAHSGGSHTSRTGRRSSTRFTCPHCAKVCKTAAALNRHGQRHAVERPGGTPTPVIAYSKGSIGTRPTDVKEEAPQEMQVSSSSGEAGSGSAAAAEASESASLQDPVISGGEEPPVAGGGSYVYPPVQEFPLALIGGSREPSAGKGKPGNEGSLGASEGDRMEGMGTAKVTFYPEPYPLVYGPQLLAAYPYNFSNLAALPVALNMVLPDEKGGGALPFLPGVFGYAVNPQAAPPTPPPPLPLPVSPKGIGGMTGVERTQKGDVG
What is the function of this protein?
Transcriptional repressor with bimodal DNA-binding specificity.  Represses transcription in a methyl-CpG-dependent manner.  Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS).  Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA.  Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912).
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 4.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to chromocenters.
Protein: DEOD_SALAR
Sequence: MATPHINAEMGDFADVVLMPGDPLRAKHIAETFLEDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVRMDVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGVDARVGNLFSADLFYSPDGDMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDKE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: PURA_BRUSI
Sequence: MANVVVVGSQWGDEGKGKIVDWLSERADVIVRYQGGHNAGHTLVIDGVSYKLSLLPSGLVRGKLSVIGNGVVVDPHHFVAEVEKLRGQGIDVTPDVLRVAENAPLILSIHRELDAMREGSNSGLKIGTTKRGIGPAYEDKVGRRAIRVIDLTEPETLRPKVERLLAHHNSLRRGMGLEEIAVETILTELTSVADQILPYIDQVWRVLDERRKAGARILFEGAQGALLDNDHGTYPFVTSSNTVAGQAAAGSGLGPTAIGYVLGITKAYTTRVGEGPFPTELNDEIGEFLGTKGHEFGVVTGRKRRCGWFDAVIVRQTVRTSGINGIALTKLDVLDGLEEIKICVAYELDGKRIDYLPSSMGAQARVKPIYETLPGWSETTAGARSWNDLPAQTVKYVRHIEELIGAPVAMLSTSPEREDTILVTDPFHD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA2_PSEPK
Sequence: MFSRDLTIAKYDAELFEAMQQEALRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHAGSQANAAVYLALLSAGDTILGMSLAHGGHLTHGASVSSSGKLYNAIQYGIDGNGLIDYDEVERLAVEHKPKMIVAGFSAYSQVLDFARFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLILARANADIEKKLNSAVFPGAQGGPLEHVIAAKAICFKEALQPEFKAYQQQVVKNAQAMASVFIERGFDVVSGGTQNHLFLLSLIKQEISGKDADAALGKAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDAVREKVKAICKKLPVYGN
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 2, SHMT 2, Serine methylase 2.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_NATPD
Sequence: MQPRDLSHHVAYEAGRGIEEVARELGLDPDDLVKLSSNENPFGPSPKAAEAIREHADRVNSYPKAAATDLRGEIGDLLSVDAAQVWLGNGGDGALDYLARAMLDPDDGVLVPDPGFAYYGMSARYHHGQVNSYPIEKDDDFEQSPDAILESYDGERIVYLTSPHNPTGSEVSLSDVEAVAEGTDEETLVVVDEAYGEFADSPSAVALVEERDDVAVLRTFSKAYGLAGVRLGYAVVPGEWADAYARVNTPFAASEIACRAGLAALEDDAHVEKTVETARWAREYIRSTLECRTYESAGNFVLCAVGDGGEVAEAAQKEGVIVRDTTSFGLPSCIRITCGTREETKRAVEVVNDLL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: NMU_RABIT
Sequence: FPVDEEFQSPFGSRSRGYFLFRPRN
What is the function of this protein?
Stimulates uterine smooth muscle contraction and causes selective vasoconstriction.
What are the official names of this protein?
Neuromedin-U-25, NmU-25.
What is the protein family that this protein belongs to?
Belongs to the NmU family.
What are the subcellular locations of this protein?
Secreted.
Protein: INSE6_ECOLI
Sequence: MTKTVSTSKKPRKQHSPEFRSEALKLAERIGVTAAARELSLYESQLYNWRSKQQNQQTSSERELEMSTEIARLKRQLAERDEELAILQKAATYFAKRLK
What is the function of this protein?
Involved in the transposition of the insertion sequence IS3.
What are the official names of this protein?
Transposase InsE for insertion sequence IS3fA.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: NEP_I03A0
Sequence: MDSNTVSSFQDILVRMSKMQLASSSEDLNGMITQFESLKLYRDSLGEAVMRMGDFHSLQIRNGKWREQLSQKFEEIRWLIEEVRHRLKITENSFEHITFMQALQLLLEVEQEIRAFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: GATB_BORPE
Sequence: MNWEIVIGLETHTQLSTDSKIFSGSSTRFGAAPNTQANAVDLALPGSLPVMNRGAAERAILFGLAVGGKVAPRSVFARKNYFYPDLPKGYQISQYELPVVEGGTLSFFVGEEEKTVNLTRAHLEEDAGKSLHDEFSLASGAPASGIDLNRAGTPLLEIVTEPEMRSAAEAVAYARALHSLVVWLGICDGNMQEGSFRCDANVSVRPVGQKEFGTRTEIKNVNSFRFLERAILFEARRQIELIEDGGTVVQETRLYDADRDETRSMRSKEDAHDYRYFPDPDLPPLVIGQDWIDAVRAGMPELPAAQRARFEADYGLPAYDAAQLTVSRAMADYFEAVARALPAGQAKLAANWIMGEVAATLNREEKDIDAAPVSAAALAALINRIIDGTISNKIARDVFAAMWAGENGGDADAIIEARGLKQISDSGAIGAMIDEVLAANPAIVEEYRAGKQKAFNSLVGQIMKAAKGKANPQQVNELLKEKLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: CLKTX_ISOMC
Sequence: FLVLLLVSLMCYAEIAEGSQPTECKYGRPCNSDRDCCWEYRCLSSGREYTCKQDPGP
What is the function of this protein?
This recombinant peptide inhibits voltage-gated potassium channels mKv1. 3/KCNA3 (IC(50)=1. 70 uM), mKv1. 1/KCNA1 (10 uM inhibits 40% of currents) and hKv1. 2/KCNA2 (10 uM inhibits 42% of currents) (PubMed:21308893).  May also increase intracellular calcium release through the activation of nuclear inositol 1,4,5-trisphosphate receptors (ITPR) of cardiomyocytes, thereby causing an increase in the contraction frequency of these cells (By similarity).
What are the official names of this protein?
Potassium channel toxin KTx1, ImKTx1.
What is the protein family that this protein belongs to?
Belongs to the scorpion calcin-like family. KTX subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMD_PASMU
Sequence: MLVGIISLFPEMFKAITEFGVTGRAVKQNLLQVRCWNPRDFTHDKHKTVDDRPYGGGPGMLMMVQPLRDAIQAAKAEVGEGAKVIYLSPQGRKLDQAGVKELAQHQKLILLCGRYEGIDERLIETEVDEEWSVGDYVLTGGELPAMTLIDAVARFIPGVLGKQASADEDSFAEGLLDCPHYTRPEVLDGLAVPPVLMSGNHEEIRKWRLRQSLERTWLRRPELLESLALTDEQRKLLKQIKAEHS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.