PharMolix/UniProtQA huggingface dataset:
Protein: CTXD_CERCA
Sequence: MANLKAVFLICILAFIAFHCVVGAPTAEDSIVVKRSIGTAVKKAVPIAKKVGKVAIPIAKAVLSVVGQLVG
What is the function of this protein?
Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria.  They have as well hemolytic activity.
What are the official names of this protein?
Ceratotoxin-D.
What are the subcellular locations of this protein?
Secreted.
Protein: PDXY_DEIGD
Sequence: MTSSSAPVLPQNILSIQSWVSYGHVGNAAALFPLQRLGFEVWTINTVQFSNHTGYGEWTGSVFPPELVADLLNGIAARGVLPTCAAVLSGYMGSEGTVSAVVEAVRRVREANPAALYCCDPVMGDVGRGVFVRPELPDLIRTQAVPEADIVTPNQFELELLTGRRVTRLQEALDASRMLRGTLREGGPRLVVVTSLVREDAPQGVIETLAVTGEGAWLCRTPLLPLDPPRNGTGDAIAALFLGHYLRTQDAGTALSLSMSALFAVLDLTHRVGTREIQLVAAQDEYTRPSRVFEAERVA
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.
Protein: BRDT_RAT
Sequence: MSLPSRQMAIVNPPPPEYINAKKTGRLTNQLQFLQRVVLKALWKHSFSWPFQQPVDAAKLKLPDYYTIIETPMDLSTIKKRLENRYYEKASECVGDFNTMFSNCYLYNKPGDDIVVMAQALEKLFMQKLSQMPQEEQIVGGKERMKKDIQQKTAVSSAKEQTPSKSAENVFKRQEIPAGFPDVCLSPLNMAQEAPPTCDSQTVVQITKGVKRRADTTTPTTSSAKASSESPPPLREAKPANAPVKENTVKSVLPDSQQQHRVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDVDALGLHNYYDIVKNPMDLGTIKGKMDKQEYKDACEFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFEMHFAKIPDEPVESMRACHLTTNSAKALSRESSSEASSGDCSSEDSEDERVQRLAKLQEQLNAVHQQLQVLSQVPLRKLKKKNEKSKRAPKRKKVNRDENPKKKAKQMKQKEKAKSNQPKKKKPLLKLEEEDNAKPMNYDEKRQLSLDINKLPGDKLGRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPHAKKVVRSKEELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVAVSPRPPLPPPPPPPPELASGSRLSDSSSSSSSSGSGSSSSSSSSSGSGSSSSDSSSSDSSDSEPEISPKFTGVKQNDLPSKENTKQIQCSVPDITSAETALVQQSTGPCGAPGKPPQQMPGCQVPHHLQATESTASVQTQPLAGDCKRVLHGPPVVHASAESHTVLELQCHAPVQKDIKIKNADSWKSLGKPVKASSVLKSSDELFNQFRKAAIEKEVKARTQEQIRKHLEHSAKDPKVSQESQREFGSGFTPESSSNKVQGRSHGEEQSEQQQLPSPSETQDISKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD
What is the function of this protein?
Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis.  Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time.  In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA.  Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac).  Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids.  Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.
What are the official names of this protein?
Bromodomain testis-specific protein.
What are the subcellular locations of this protein?
Nucleus. Note=Detected on chromatin.
Protein: HIS2_LEPIN
Sequence: MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTHEVADLLFHLQVLLVEQGLSLQEIVEELHKRHS
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_NOVAD
Sequence: MALILGIESSCDETAAAVIDSNGASLEARIVAQRIASQDEAHRPYGGVVPEIAARAHAEVLSPMIAAVLADAGIGLDDLDAIAATAGPGLIGGVMVGLVTGKALAMAADKPLIAVNHLEGHALSPRLAEPSLQYPYLLLLVSGGHCQILEVAGVGQFRRLATTIDDALGEAFDKTAKILGLGYPGGPAVERMAREGNPKAVPLPRPLVGSGEPHFSFAGLKSAVMRAKDAGVHGDADIAASFQQAAIDCVIDRTRIALETASPGMTALVVAGGVAANAALRGALEGLAESHGLSLVAPPPKLCTDNAAMIGWAGAERLALGYVDPLDVAARPRWPLDENAAPVRGAGVKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK14_SACOF
Sequence: MIQPQTLLNVADNSGARKLMCIRVIGAAGNQRYARIGDVIIAVIKDAVPQMPLERSEVIRAVIVRTRKEFKGDDGIIIRYDDNAAVIIDQKGNPKGTRVFGAVAEELRELNYTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: VPS51_BOVIN
Sequence: MAAAAAAPGPGSGPGDSPEGPEAEGPERRRKAHGMLKLYYGLSEGEAAGRPSGPDPLDPTDLNGAHFDPEVYLDKLRRECPLAQLMDSETDMVRQIRALDSDMQTLVYENYNKFISATDTIRKMKNDFRKMEDEMDRLATNMAVITDFSARISATLQDPHERITKLAGVHALLRKLQILFELPSRLTKCVELGAYGQAVRYQGRARAVLQQYQHLPSFRAIQDDCQVITARLAQQLRQRFREGGSGAPEQAECVELLLALGEPAEELCEEFLAHARGRLEEELRSLEAELGPSPLAPDVLEFTDHGGSGFVGGLCQVAAAYQELFAAQGPAGAEKLAAFARELGSRYFALVERRLAQEQGSGDNSLLVRALDRFHRRLRAPGALLAAAGLAEAATEIVERVARERLGHHLQGLQAAFLGSLTDVRQALAAPRIAGKEGPGLAELLANVASSILSHIKASLASVHLFTAKEVSFSNKPYFRGEFCSQGVRESLIVGFIRSMCQTAQSFCDSPGEKGGATPPALLLLLSRLCLDYETATISYILTLTDEQFLVQDQSPVTPVSTLCAEARETARRLLTHYVKVQGLVISQMLRKSVETRDWLSTLEPRNVRAVMKRVVEDTTAIDVQVGLLYEEGVRKAQSSDSSKRTFSVYSSSRQQGRYAPSYTPSAPMDTNLLSNIQKLFSERIDVFSPVEFNKVSVLTGIIKISLKTLLECVRLRTFGRFGLQQVQVDCHFLQLYLWRFVADEELVHLLLDEVVASAALRCPDPVPMEPSVVEVICERG
What is the function of this protein?
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).  The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy.  VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.  Acts as component of the EARP complex that is involved in endocytic recycling.  The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 51 homolog, Protein fat-free homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS51 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
Protein: CCSA_NASOF
Sequence: MIFSILEHILTHISFSVISIVLTIYFLTLLVNLDEIIGFFDSSDKGIVITFFGITGLLFTRWIYSGHFPLSNLYESLIFLSWAFSIIHMVSYFNKKKKNHLNAITAPSAIFIQGFATSGLLNKMPQSAILVPALQSQWLMMHVSMMILGYGALLCGSLLSMALLVITFRKVGPTFLQKNIKKKFLLTELFSFDVFYSINEKNAILLQQNINFSFSRNYYRYQLIEQLDYWSFRIISLGFIFLTVGILSGAVWANETWGSYWNWDPKETWAFITWTIFAIYLHIKTNRNVRSINSAIVASIGFILIWICYFGVNLLGIGLHSYGSFTSN
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RK33_ANGEV
Sequence: MAKSKDVRVTITLECISCDRNNSDKRFPGVSRYTTRKNQRNTPTRLELKKFCPYCSEHTIHRELKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EFTS_STRAW
Sequence: MANYTAADVKKLRELTGAGMMDCKKALDEAEGNVEKAVEALRIKGQKGVAKREGRSAENGAVVSVIADDNASGVLVELKCETDFVAKGEKFQAAANAIAEHVAKTAPADLEALLASEIEPGKTVQAFVDEANANLGEKIVLDRFAAYADGYVSAYMHRTMPDLPPQIGVLVELDKPNAEIAKGVAQHIAAFAPKYLSKEDVPAEVVESERRVAEETTRAEGKPEAALPKIVEGRLNGFFKDATLLGQPYALDNKKSVQKVLDEAGVTLKRFTRIKVGI
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQB_XANCB
Sequence: MRIIVLGSAAGGGHPQWNCHTPASQRAWQQADGAQRRTQASIAVSADGQRWVLINASPDFRQQILATPALWPQHGLRHSPIESVLLTSGEIDHIAGLLSMRESQRFSLHASSRVLDLLAQNPIFDALNPQYVDRHPFALNTPLTLCDLQLTPFSVPGKVPLFMESRSGGDLAGSNEETLGLTIDDGRHRVHYIPGCAAMTDDLRARLHGAELVFFDGTLWRDDEMVQLGVSQKTGQRMGHMSIDGTDGTLAAFAQLQVARKVLIHINTTNPVLDAHSPEHAAVRAAGWDVAHDGLEISL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.
Protein: ZNTB_SALSV
Sequence: MEAIKGSDVNVPDAVFAWLLDGRGGVKPLEDNDVIDSQHPCWLHLNYTHPDSARWLASTPLLPNNVRDALAGESSRPRVSRMGEGTLITLRCINGSTDERPDQLVAMRLYMDERFIVSTRQRKVLALDDVVSDLQEGTGPVDCGGWLVDVCDALTDHASEFIEELHDKIIDLEDNLLDQQIPPRGFLALLRKQLIVMRRYMAPQRDVYARLASERLPWMSDDHRRRMQDIADRLGRGLDEIDACIARTGIMADEIAQVMQESLARRTYTMSLMAMVFLPSTFLTGLFGVNLGGIPGGGWRFGFSLFCILLVVLIGGVTLWLHRSKWL
What is the function of this protein?
Zinc transporter.  Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.
What are the official names of this protein?
Zinc transport protein ZntB.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FABZ_STRP7
Sequence: MIDIQGIKEALPHRYPMLLVDRVLEVSEDTIVAIKNVTINEPFFNGHFPQYPVMPGVLIMEALAQTAGVLELSKPENKGKLVFYAGMDKVKFKKQVVPGDQLVMTATFVKRRGTIAVVEAKAEVDGKLAASGTLTFAIGN
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_SALNS
Sequence: MGKIIGIDLGTTNSCVAIMDGTQARVLENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPYKIIGADNGDAWLDVKGQKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKEVGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDTRLINYLVDEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDINDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLTGDVKDVLLLDVTPLSLGIETMGGVMTPLITKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRASDNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEEEIQKMVRDAEANAESDRKFEELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALNALETALKGEDKAAIEAKMQELAQVSQKLMEIAQQQHAQQQAGSADASANNAKDDDVVDAEFEEVKDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: DUT_DINSH
Sequence: MSLMIEVLREPWADEAIPLPSYATVGAAGADLRANLPPEIRDQGVEIQPLCRVIVPTGLRVAIPAGYEMQIRPRSGLALKHGLSLPNTPGTIDSDYRGPLGVLLTVIGTEAVTLHHGDRIAQAVIAPVVQAVFAPVDRLEETARGAGGFGSTGRG
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RT25_COCIM
Sequence: MGKFNLGALRVRQNALAQKSSGKISQTPCWVDIVSEIPPATVLVRNLPQQHALVQQRVKTLPGKSRPQTVIEEREIRRIKTKKASRMFQPMQIRYEEDELRKQFFQDHPWELARPRVVLETNGNDHARYDWSRLQQRGKRLDGESVVQRQLYLLNNVPDITKGEAYDIARREFYQLRLQEDIERRVAQEEARATGAYFGPDMMQVGMELENQEYDRWKIWAEKEAEQASQRLAAFAGATGGAKEESDPAILPELEVAESTSESAQPAEIRTG
What are the official names of this protein?
37S ribosomal protein S25, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS23 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GPMA_GEOSL
Sequence: MRTLVLIRHGESVWNRENRFTGWTDVGLTDKGAAEALRAGRTLKNEGFAFDEAFTSVLKRAIKTLWIVLEEMDQMWIPEHRHWRLNERHYGALQGLNKAETAERHGMEQVHVWRRSYDIPPPPLAAGDPRNPARDPRYAELDPADIPLTESLKDTVARFLPYWHETIAPRILAGRRLLIAAHGNSLRALVKYLDGIGDDAIAGLNIPTGIPLVYELEDDLHPIRSYYLGDPDEVARATQSVADQVKR
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: FXI2B_XENLA
Sequence: MNTFGQQTSNPHAQDLLDMAKYYDHFNHYHQQQNQQLPQRPAAPPAPGYGLNEFSPPTANPYLWLNGPAINSSPYLNGGSGSPYFPTGYGGGQRQFLPPSSGFGVADFPWLSIPNQADLLKMVRPPYSYSSLIAMSIQNTPDKKLTLSQIYNYVAENFPFYKKSKAGWQNSIRHNLSLNDCFKKVARDDNDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSEIVGAGFDEESNEDKKPLALKSLGPDSPGGASVVLEQSSYTAPEGKNKSPVGSVARDSSHCFTNFASNMNALINGRAPRQFSAGHGDFSNSRHYLAELASCPISSPPISEAQTKVACYPSKQQNSLCTSVLNPFSLNHVYSREGEV
What is the function of this protein?
Possible transcriptional activator.
What are the official names of this protein?
Forkhead box protein I2-B, XlFoxI2-B.
What are the subcellular locations of this protein?
Nucleus.
Protein: LCYB_TOBAC
Sequence: MDTLLKTPNKLEFLHPVHGFSVKASSFNSVKPHKFGSRKICENWGKGVCVKAKSSALLELVPETKKENLDFELPMYDPSKGLVVDLAVVGGGPAGLAVAQQVSEAGLSVVSIDPSPKLIWPNNYGVWVDEFEAMDLLDCLDATWSGTVVYIDDNTTKDLDRPYGRVNRKQLKSKMMQKCILNGVKFHHAKVIKVIHEEAKSMLICNDGVTIQATVVLDATGFSRCLVQYDKPYKPGYQVAYGILAEVEEHPFDTSKMVLMDWRDSHLGNNMELKERNRKVPTFLYAMPFSSNKIFLEETSLVARPGLRMDDIQERMVARLNHLGIKVKSIEEDEHCVIPMGGSLPVIPQRVVGTGGTAGLVHPSTGYMVARTLAAAPVVANAIIHYLGSEKDLLGNELSAAVWKDLWPIERRRQREFFCFGMDILLKLDLPATRRFFDAFFDLEPRYWHGFLSSRLYLPELIFFGLSLFSRASNTSRIEIMTKGTLPLVNMINNLLQDTE
What is the function of this protein?
Catalyzes the double cyclization reaction which converts lycopene to beta-carotene and neurosporene to beta-zeacarotene.
What are the official names of this protein?
Lycopene beta cyclase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the lycopene cyclase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RNPA_SHEDO
Sequence: MTSYTFSRELRLLTPAQFKSVFSNPIKASSAEITLLAIPNIEQHPRLGLTVAKRFVKRANQRNRIKRVIRESFRLNQHDIPALDIVVLVRNGVMEMENADLNKLIEKLWRKLSRRYNG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: IL32_HUMAN
Sequence: MCFPKVLSDDMKKLKARMVMLLPTSAQGLGAWVSACDTEDTVGHLGPWRDKDPALWCQLCLSSQHQAIERFYDKMQNAESGRGQVMSSLAELEDDFKEGYLETVAAYYEEQHPELTPLLEKERDGLRCRGNRSPVPDVEDPATEEPGESFCDKVMRWFQAMLQRLQTWWHGVLAWVKEKVVALVHAVQALWKQFQSFCCSLSELFMSSFQSYGAPRGDKEELTPQKCSEPQSSK
What is the function of this protein?
Cytokine that may play a role in innate and adaptive immune responses.  It induces various cytokines such as TNFA/TNF-alpha and IL8.  It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.
What are the official names of this protein?
Interleukin-32, IL-32, Natural killer cells protein 4, Tumor necrosis factor alpha-inducing factor.
What are the subcellular locations of this protein?
Secreted.
Protein: IXTPA_CAUVC
Sequence: MGAKLVAATHNPGKVPEIAALLDGRFEIVTAGQLGLPEPDETESTFVGNALLKARHAADLSGLPALADDSGLSVTALDGAPGIFSARWAGPGKDFALAMKKVEERLEETASDDRTAWFTSALAVAWPNGPAVVVEGRVDGTLVFPGRGTRGFGYDPIFVPEGHALTFGEMEPAAKDAMSHRARAFAKLKAALFD
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: RLMI_ECOSM
Sequence: MSVRLVLAKGREKSLLRRHPWIFSGAVARMEGKASLGETIDIVDHQGKWLARGAYSPASQIRARVWTFDPSESIDIAFFTRRLQQAQKWRDWLAQKDGLNSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALISALQTLYPECAIYDRSDVAVRKKEGMELTQGPVTGELPPALLPIEEHGMKLLVDIQHGHKTGYYLDQRDSRLATRRYVENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQLLNEGGVLLTFSCSGLMTSDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVM
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXE3_MOUSE
Sequence: MDAQVAFSGFPALPSLTPSGPQLPTLAGAEPGREPEEVVGGGDAEPTAVPGPGKRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRKRFKRAELPAPPPPPPPFPYAPFPPPPAPASAPPARLFRLDSLLGLQPEPPGPVAPEPPCCAAPDAAFPPCAAAASPPLYSPASERLGLPAPLPAQPLLALAGSAGALGPLGAGEAYLRQPGFAPGLERYL
What is the function of this protein?
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:10652278, PubMed:10890982).  During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (PubMed:16199865).  Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (PubMed:10652278).  Is required for morphogenesis and differentiation of the anterior segment of the eye (PubMed:17064680).  Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity).
What are the official names of this protein?
Forkhead box protein E3.
What are the subcellular locations of this protein?
Nucleus.
Protein: ENGB_SALTI
Sequence: MTNLNYQQTHFVMSAPDIRHLPSDCGIEVAFAGRSNAGKSSALNTLTNQKSLARTSKTPGRTQLINLFEVVDGKRLVDLPGYGYAEVPEEMKRKWQRALGEYLEKRQSLQGLVVLMDIRHPLKDLDQQMIQWAVESNIQVLVLLTKADKLASGARKAQLNMVREAVLAFNGDVQVEAFSSLKKQGVDKLRQKLDSWFSELAPVEEIQDGE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: MDR2_ASPFU
Sequence: MRGIRSLPCWAPGLSTKRIPPRELFADLFPNACVISARHSARNGLIRQFSGCSGSISNSCNPRPYRSAITSLLSANVCSKGVSAVQPRFLSTVRLFSTSQRSLEPKSNVKSTGGQVVRPELHQDQEHEDIEKGFELSERAAQAAQVNLSAKLAKDGAAGKKAGFKEIWRLLLIARPEAKKLALAFLFLLVSSGITMSIPFSIGKIMDTSTKATTEGGNELFGLSLPMFYGALAGILTLGAAANYGRIIILRIVGERIVARLRSKLFRQTFVQDAEFFDANRVGDLISRLSSDTIIVGKSITQNLSDGLRAAVSGAAGFGLMAYVSLKLSSILALLLPPIGLGAFFYGRAIRNLSRQIQRNLGTLTKIAEERLGNVKTSQSFAGEVLEVRRYNNQVRKIFELGKKESLISATFFSSTGFAGNMTILALLYVGGGMVQSGAITIGELTSFLMYTAYAGSSMFGLSSFYSELMKGVGAASRLFELQDRQPTISPTKGEKVASARGPIRFENVTFSYPTRPAVPIFRDLNFEIPQGTNVAIVGPSGGGKSTIASILLRFYSPTEGRVLIGGKDITHMNAKSLRRKIGIVSQEPVLFSGTIAENIAYGKPQAKRSEIVAAARKANCQFISDFPDGLDTQVGPRGAQLSGGQKQRIAIARALIKDPDILILDEATSALDAESETLVNSALTALLRGNNTTISIAHRLSTIKRSDTIIVLGPDGRVAEQGSYEELSARPDGAFTKLMEWQMSGGEVMDQLANTPANPVAQETSWDLQSDDGTEISEDTNIPSEPRTID
What is the function of this protein?
Pleiotropic ABC efflux transporter that may be involved in A. fumigatus adaptation to azoles.
What are the official names of this protein?
ABC multidrug transporter mdr2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ITIH5_MOUSE
Sequence: MLLLLGLCLGLPLFSESQEEARSWDDTSEQVVLRVPRQLRLLQRLKTKPLMAEFSVKSTIISRYAFTTVSCRMLNRASEDQEAEFQMQIPESAFITNFTMLIGDSVYRGEITQKDKKSSESVKDKRNRTSDDNEENGSDMFKASLVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLVGRLTVEVDILERSGITSLEVLPLHNSRKKGSGKAEGDVGPPPSTLINQNETFAKVIFKPTVVQQAKIAQNGILGDFIVRYDVEREQNIGDIQVLNGYFVHYFAPKNLPPLPKNVVFVLDISASMVGAKLQQTREALVTILNDLRPQDRFNIIGFSNRIKMWKDHLLPVTPDNIRNGKIYMYHLSPTGGTDINGALQAAIKLLNNYVAQNDIEDRSVSLIIFLTDGKPTFGETNTLKILSNTKEATRGQICIFTVGIGDDVDFKLLEKLSLENCGLTRRVHEEDKAGAQLIGFYDEIRTPLLSDIRIDYPPDVVEHATKTLFPNYFNGSEIVIAGKMVDKKFDQLHVEVTASNSKKFVILKRDIPVEFRKMGNDVSVTPGSARDGGKDLNHIERLWSYLTVKELLSSWRQSNSEQEKEQLRQKAQDLALNYHFLTPFTSMKLRKPGLRTNQLEDTYGMSAATGPATVVQNLREAGKQPEPDLKKTYDPRIKISKTSVDGDPHFVVDFPLSKLTVCFNIDGEPGDILRLVSDHLNSGVTVNGELIGAPAPPNGHKKQRTYFRTITILINRPERSYLEITPSRVILDGGDRLVLPCNQSVVVGSRGLEVSVSANANITVVIQGNIAFVILIHLYKNPAPFQRDHLGFYIANSRGLSDNCHGLLGQFLNQDAKLVGAPEEYGKNLSNQPFPRAEGMPEAILKVKGRRVPVVWKQRKIYNGQAQVDCWFDRNNAAKLIDGVYKDYLASHPFDTESALGLSTPRKPETDRPHEESV
What is the function of this protein?
May act as a tumor suppressor.
What are the official names of this protein?
Inter-alpha-trypsin inhibitor heavy chain H5, ITI heavy chain H5, ITI-HC5, Inter-alpha-inhibitor heavy chain 5.
What is the protein family that this protein belongs to?
Belongs to the ITIH family.
What are the subcellular locations of this protein?
Secreted.