PharMolix/UniProtQA huggingface dataset:
Protein: COBQ_CLOBM
Sequence: MAKIMIQGTASSVGKSLIVAALCRIFKQDGYSVCPFKSQNMSLNSYITLDGKEMGRAQVLQAYAAGLEPEVYMNPILLKPTSDKKSQIIVNGKVYGNSTAMEYHNLKIKFKDMLKEQFKKLEENFDIVVMEGAGSPAEINLRDRDIVNMGMAELVDAPVLLVGDIDKGGVFASLAGTMLLLNEGEKERVKGTIINKFRGDVEILKPGLDMLEDIIHIPCLGVVPYTRLQLEDEDGAVEFNKKTYAPIDIAVIKMPHISNFTDLDALKSEEDVSIRFVTSKEELKKPDLLIIPGSKNTIEDLLYLRQCGLEESIKEYSNDGRIIGICGGYQVLGSKIKDPHNVETDLGEIDGLNLLDMKTIFEKEKVTTRVSAKLLNEEAENTVYGYEIHMGISKYGQNINPLFKIYDKNGEKVGYFDGAINDKGNVMGTYIHGVFDGVAFREKIINELRVKKGLKKKKSQVYEHMREKELDKLADIVRQSLDMKKIYSIIGMK
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: RL32_VEREI
Sequence: MAVQQNKKSPSKRGMHRSHNALALPGIAVEPTSGEVHLRHHISPNGFYRGRQVLKPKSEA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: PFKA_STRP3
Sequence: MKRIAVLTSGGDAPGMNAAIRAVVRKAISEGMEVYGINRGYAGMVDGDIFPLGSKEVGDKISRGGTFLYSARYPEFAQLEGQLAGIEQLKKHGIEGVVVIGGDGSYHGAMRLTEHGFPAVGIPGTIDNDIAGTDYTIGFDTAVNTAVEAIDKLRDTSSSHGRTFVVEVMGRNAGDIALWAGIASGADQIIVPEEEFDIEKVASTIQYDFEHKGKNHHIIVLAEGVMSGEAFAQKLKEAGDKSDLRVTNLGHILRGGSPTARDRVIASWMGSHAVELLKEGKGGLAVGIHNEELVESPILGTAEEGALFSLTEEGQIIVNNPHKARLDFAALNRSLSQ
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF1B_RAT
Sequence: MDVEQMKAFTDRCSQCAAVSWGLTDEGKYYCTSCHNVTDRSEEVVSTAVIPNTKINSISRGLRQRSKHEKGWDWYVCEGFQCILYHQAEALETLGVSPELKNEVLHSFWKRYLQKSKQAYCKNPVRTSGRKAKVLEDNLQSSDWGSDFELLSDTTCPPESGAEFQSDSQTPKPFPATKRSSKSASVCSGSVDGVEYSERKEKGLLKMTVPRTLALCYLSLLWQRETITLSDLLRFVEEDRIPYINAFKVFPEEMKVYGRDKGIFAVESWPDYEDIYKNMIEVAVFLDLPRFPDITEDCYLHPNTLCMKYLLEVNLPEEMYTLTCQVVKLTGIGEVDFLTFDPIAKMTRTVKHDVQAVAVIVLVLKLLFLLDDKLEWSYSDLAEAYNEGHKEETPQFDFRKWYQVMKKTFDEKRRKWEEARAKYVWKTKRPLYRSHIDKSVAYKRREMVENLQKQFSALIGSAPEVERQAPSSFQLNWTGEDTGSPCFHGHSLQGLLISKGQALITKNSLYWLSTHKFCKSYCKHVTTYEESNFSLSYQFILNIFSFLLRIKTSALHEEVSLLEKKLFEKKYNESKRSSRSKKVRRH
What is the function of this protein?
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription.  Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 (By similarity).
What are the official names of this protein?
TATA box-binding protein-associated factor RNA polymerase I subunit B, RNA polymerase I-specific TBP-associated factor 63 kDa, TAFI63, TATA box-binding protein-associated factor 1B, TBP-associated factor 1B, Transcription initiation factor SL1/TIF-IB subunit B.
What is the protein family that this protein belongs to?
Belongs to the RRN7/TAF1B family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NANM_YERP3
Sequence: MTQLYPQYKKQLTTKIVLFSALSLLMMASLPNTYAEQYPDVPVPFKNGTGGKVENSLYVGLGSAGVSWFRLDTDKTGAGWQKVANFPGQPREQAVTVVLAGKLYVFGGVGKTNANDTQVRALDDAYRFDPQTNQWQQLATRAPRGLVGTVATTLDGSQAVLLGGVNKAIFDGYFTDLASAGSDEVRKSAVINAYFNQAPADYFYNRDVLIYDPQKNQWKSGGLLPFLGTAGSAISRMDNRLILINGEIKPGLRTAAVWQGLMQGNVLEWQPQPDLIGAETGSAQEGLAGAFSGISHKTVLVAGGANFPGAWKQFNRGHLYAHQGLEKQWHQQVYALVDNQWRIAGKLPQPLGYGVSIQGPDKVILIGGETTGGTATSAVTQLSWQGGKLHIE
What is the function of this protein?
Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers.  Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer.  In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
What are the official names of this protein?
N-acetylneuraminate epimerase, N-acetylneuraminate mutarotase, Neu5Ac mutarotase, Sialic acid epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanM family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SYC_SHEB5
Sequence: MLKIYNSITRQKQEFKPITPGKIGMYVCGVTIYDLCHIGHGRTFVSFDMIVRYLRYAGYEVNFQRNITDVDDKIIKRANENNESCEALTERLIGEMHQDFDALNMLRPDFEPRATLHIAEIIDMVELLLARGHAYVASDGDVLFSVASYPDYGRLSGQNLDQLQAGARVEVDETKQNPMDFVLWKMSKPGEPTWESPWGPGRPGWHIECSAMNSKHLGLHFDIHGGGSDLQFPHHENEIAQSCCAHDTPYVNYWMHTGMVMVDREKMSKSLGNFFTIRDVLGHYDAETVRYFLLSGHYRSQLNYSEDNLKQARSALERLYTAIKDVDLTVAAAPAEEFVAKFKAAMDDDFNTPEAYSVLFDMVREINRLKLTDMAQASALAVTLKQLADVLGLLSQEPEAFFQGGGSYDEVAEIEALIVERNRARTEKDWAAADVARNCLNELGVELEDGPSGTTWRKK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_NEIMB
Sequence: MNLTKTQRQLHNFLTLAQEAGSLSKLAKLCGYRTPVALYKLKQRLEKQAEDPDARGIRPSLMAKLEKHTGKPKGWLDRKHRERTVPETAAESTGTAETQIAETASAAGCRSVTVNRNTCETQITVSINLDGSGKSRLDTGVPFLEHMIDQIARHGMIDIDISCKGDLHIDDHHTAEDIGITLGQAIRQALGDKKGIRRYGHSYVPLDEALSRVVIDLSGRPGLVYNIEFTRALIGRFDVDLFEEFFHGIVNHSMMTLHIDNLSGKNAHHQAETVFKAFGRALRMAVEHDPRMAGQTPSTKGTLTA
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSP_DINSH
Sequence: MGFSLTDYAPYDFANRRHIGPSPKEMGQMLATLGVPSLEALINEALPEGIRRRDPLAFGPALSERDTLHRMRELADKNTVLTSLIGQGYHGTHTPPVILRNILENPAWYTAYTPYQPEISQGRLEALLNFQTMMADLTGLPIANASLLDEGTAAAEAMAMAQRASKSKARGFFVAEDCHPQTIDVIRTRAEPLGIEVIVGAVDALDPEAVFAALFQYPGSYGHVRDYSDVIEALHGARALAVVAADPLALTLLKSPGEMGADIAIGSTQRFGVPMGYGGPHAAYMTCTDALKRSMPGRIIGVSVDARGNKAYRLSLQTREQHIRREKANSNVCTAQALLAVMASMYGVFHGPDGLKAIAQTVHRKTARMADGLTELGFKVDPQDYFDTITVKVGSMQGVILAAALREGVNLRKVGTDRIGITLDELTLGRTIEAVWRAFGAEGMVYDKTRMVYHLPQEMLRESSYMTHPIFHMNRAEAEMTRYMRRLADRDLALDRAMIPLGSCTMKLNATVEMLPLTWPEFANLHPFAPADQAAGYHEMIAELSQMLCDVTGYDAMSMQPNSGAQGEYAGLLAIRGYHRARGEGHRNICLIPTSAHGTNPASAQMVGWKVVVVKSAENGDIDLEDFRAKAEQHSENLAGCMITYPSTHGVFEEIVREVCDITHAHGGQVYIDGANMNAMVGLSAPGDLGGDVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPHLPSHATATGAGFGDAGAVASAAYGSPSILTISYAYCLLMGGAGLTQATKVAILNANYMAKRLSAGFPILYANDKGRVAHECILDTRVLDKIAGVTVEDVAKRLMDCGFHAPTMSWPVAGTLMVEPTESEPKAELDRFCDAMLAIREEADAIAAGSLDAENNPLKRAPHTVEDLVGDWDRPYSREQACYPPGAFRVDKYWPPVNRVDNAYGDRNLVCTCPPVEDYAEPAE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: NPH2_VACCT
Sequence: MEKNLPDIFFFPNCVNVFSYKYSQDEFSNMSKTERDSFSLAVFPVIKHRWHNAHVVKHKGIYKVSTEARGKKVSPPSLGKPAHINLTAKQYIYSEHTISFECYSFLKCITNTEINSFDEYILRGLLEAGNSLQIFSNSVGKRTDTIGVLGNKYPFSKIPLASLTPKAQREIFSAWISHRPVVLTGGTGVGKTSQVPKLLLWFNYLFGGFSTLDKITDFHERPVILSLPRIALVRLHSNTILKSLGFKVLDGSPISLRYGSIPEELINKQPKKYGIVFSTHKLSLTKLFSYGTLIIDEVHEHDQIGDIIIAVARKHHTKIDSMFLMTATLEDDRERLKVFLPNPAFIHIPGDTLFKISEVFIHNKINPSSRMAYIEEEKRNLVTAIQMYTPPDGSSGIVFVASVAQCHEYKSYLEKRLPYDMYIIHGKVLDIDEILEKVYSSPNVSIIISTPYLESSVTIHNVTHIYDMGRVFVPAPFGGSQQFISKSMRDQRKGRVGRVNPGTYVYFYDLSYMKSIQRIDSEFLHNYILYANKFNLTLPEDLFIIPTNLDILWRTKEYIDSFDISTETWNKLLSNYYMKMIEYAKLYVLSPILAEELDNFERTGELTSIVREAILSLNLRIKILNFKHKDDDTYIHFCKILFGVYNGTNATIYYHRPLTGYINIISDTIFVPVDNN
What is the function of this protein?
NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs and plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase.  Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm.  Required for replication and propagation of viral particles.
What are the official names of this protein?
RNA helicase NPH-II, Nucleoside triphosphatase II, NTPase II, Nucleoside triphosphate phosphohydrolase II, NPH II, RNA helicase I8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: PANC_SALPK
Sequence: MLIIETLPLLRQHIRRLRQEGKRVALVPTMGNLHDGHMKLVDEAKARADVVIVSIFVNPMQFDRPDDLVRYPRTLQEDCEKLNKRKVDYVFAPAVEEIYPQGLEGQTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLIQPDIACFGEKDFQQLALIRKMVADMSYDIEIVGVPIIRAKDGLALSSRNAYLTAEQRKIAPGLYNVMNSIAEKLIAGNRELQEIIAIAEQELNEKGFRADDIQIRDADTLLELTETSKRAVILAAAWLGQARLIDNQSVTLAQ
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSTM1_HUMAN
Sequence: MEPGPTAAQRRCSLPPWLPLGLLLWSGLALGALPFGSSPHRVFHDLLSEQQLLEVEDLSLSLLQGGGLGPLSLPPDLPDLDPECRELLLDFANSSAELTGCLVRSARPVRLCQTCYPLFQQVVSKMDNISRAAGNTSESQSCARSLLMADRMQIVVILSEFFNTTWQEANCANCLTNNSEELSNSTVYFLNLFNHTLTCFEHNLQGNAHSLLQTKNYSEVCKNCREAYKTLSSLYSEMQKMNELENKAEPGTHLCIDVEDAMNITRKLWSRTFNCSVPCSDTVPVIAVSVFILFLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFANIQENSN
What is the function of this protein?
Required for osteoclast and melanocyte maturation and function.
What are the official names of this protein?
Osteopetrosis-associated transmembrane protein 1, Chloride channel 7 beta subunit.
What is the protein family that this protein belongs to?
Belongs to the OSTM1 family.
Protein: WECG_ECO5E
Sequence: MNNNTTAPTYTLRGLQLIGWRDMQHALDYLFADGQLKQGTLVAINAEKMLTIEENAEVRELINAAEFKYADGISVVRSVRKKYPQAQVSRVAGADLWEELMARAGKEGTTVFLVGGKPEVLAQTEAKLRNQWNVNIVGSQDGYFKPEQRQALFERIHASGAQIVTVAMGSPKQEIFMRDCRLVHPDALYMGVGGTYDVFTGHVKRAPKIWQTLGLEWLYRLLSQPSRIKRQLRLLRYLRWHYTGNL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: RPOZ_RHOP2
Sequence: MARVTVEDCIDKVDNRFDLVLLAAHRARMISSGSQLTIDRDNDKNPVVSLREIAEQTVSPEDLKEELVHSLQKFVEVDEPEQDTVPLIGSAGASVDADDTEVALERMTEEELLKGLEGLAPPEEQPEEDE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: ADHA_MYCTU
Sequence: MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAVHACGVCRTDLHVTEGDLPVHRERVIPGHEVVGEVIEVGSAVGAAAGGEFDRGDRVGIAWLRHTCGVCKYCRRGSENLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSELAPLLCAGIIGYRSLLRTELPPGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLALQLGAASAQDAADRPPVPLDAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLNYQQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPEYPLGQADRALGDLSAGRIAGAAVLLI
What are the official names of this protein?
Probable alcohol dehydrogenase AdhA.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: TCP12_ARATH
Sequence: MFPSLDTNGYDLFDPFIPHQTTMFPSFITHIQSPNSHHHYSSPSFPFSSDFLESFDESFLINQFLLQQQDVAANVVESPWKFCKKLELKKKNEKCVDGSTSQEVQWRRTVKKRDRHSKICTAQGPRDRRMRLSLQIARKFFDLQDMLGFDKASKTIEWLFSKSKTSIKQLKERVAASEGGGKDEHLQVDEKEKDETLKLRVSKRRTKTMESSFKTKESRERARKRARERTMAKMKMRLFETSETISDPHQETREIKITNGVQLLEKENKEQEWSNTNDVHMVEYQMDSVSIIEKFLGLTSDSSSSSIFGDSEECYTSLSSVRGMSTPREHNTTSIATVDEEKSPISSFSLYDYLCY
What is the function of this protein?
Transcription factor that prevents axillary bud outgrowth.  May also delay early axillary bud development.  Probably involved in the auxin-induced control of apical dominance.
What are the official names of this protein?
Transcription factor TCP12, Protein BRANCHED 2.
Protein: UPPP_ECO55
Sequence: MSDMHSLLIAAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTAKTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGRPLQHEGESKGRLTLIHILLGMIPAVVLGLLFHDTIKSLFNPINVMYALVVGGLLLIAAECLKPKEPRAPGLDDMTYRQAFMIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATALDLYKSWGFLTTGDIPMFAVGFITAFVVALIAIKTFLQLIKRISFIPFAIYRFIVAAAVYVVFF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS7_LEGPH
Sequence: MKKILFIDRDGTLVEEPFDFQVDSLDKIKLTSGVIPALLQLQKAGFTFIMVSNQNGIGTVAFPEEDFAVCHEFILDLFSSQGILFDEIFICPHTPENNCICRKPKTGLLEPYLKETVFAKQYSWVIGDRDTDKEFADNLGVNFLPISKTHTWEMVASAIINDARKASVQRKTKETTIDLSVQLDSDQTSVIDTPIPFFTHMLEQVAKHGGFDLRLQASGDLEVDEHHLIEDTAIALGEAIRTALGDKWGINRYGYTLPMDESLATIAIDISGRSFCDFKGQFTREFIGGMATEMIPHFFQSLSSALGATIHIEVTGTNHHHMIEACFKVLGRALRQACSRTNNYLPSTKGVL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REV_HV196
Sequence: MAGRRGDPDEQLLTTVRTIKILYESNPYPNLEGSRQTRRNRRRRWRARQKQISSISERLLSACLGRSAEPVPLQLPPIEKLNLNCDEDPGKGTEGGLGSPQISVEPCTVLESGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: NADE_PICTO
Sequence: MVERLDGVFKSISDFLRQELNGKNAVIGVSSGIDSALVLTILSKAIDKDRIHAFFMPDRFTRSADFDDIRSLEGSTGVKINEINIENIVNGYKSTLGINDKKYEGNIRSRVRSVILYYNANLLNGLVVGTTNRTEYLIGYFTKYGDGACDLEPIEHLYKSDVRELASYLKVPESIIRKKPSAGLWGDQYDEDELGMGYEELDSILKDLFEKKTGILDDRYKMVYDMYIRSQHKRKLPKSMMNDDFRYNV
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: Y1235_THEP1
Sequence: MKRDGGSLLPRERMIKAGPESLSVEELVAIVLRTGKKGKHVLELSKDLLERFDGSLIKLSNAGLEEIASVEGVGMVKAITLKAALELGKRLHRELERIPEKLDSSVKVYRYCQEMVYLEREIVKVICLDTKLNVIGENTLTVGTSDRSLIHPRDVFRTAIRANASGVIVVHNHPSGDPTPSKEDRLITERLKQAGEILGVSLVDHVIVSRRGYFSFREEGEL
What are the official names of this protein?
UPF0758 protein Tpet_1235.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: COBT_MYCTU
Sequence: MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADLAAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEAGVSTRSVDGVDRTAPPAVSP
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: PDXJ_PROM4
Sequence: MASLGVNIDHIANVRQARLASEPEPVQMAFLAELGGADGITVHLREDRRHIQDKDLKLLRATINTRLNLEMAATKEMVEIALQVKPDMVTIVPESREEITTEGGLEVVNNKEKLREIINNLHSAKIQTSIFIDPIEAQIKASKEIGAGWVEIHTGCYANASWEKQEIELAKIKASCAQARSMGLHVNAGHGLTYLNVEPIAAIEGIEELNIGHTIVARALAVGLQNAVKEMKSLVTNPRRNNF
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSMA3_HUMAN
Sequence: MTTFGAVAEWRLPSLRRATLWIPQWFAKKAIFNSPLEAAMAFPHLQQPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKELHTIFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSIVMEFLDPGGPMMKLVYKLQAEDYKFDFPVSYLPGPVKASIQECILPDSPLYHNKVQFTPTGGLGLNLALNPFEYYIFFFALSLITQKPLPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSSSPGGTSPSPPPRTPAIPFASYGLHHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLSVSSALYSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPEQASPSAHSHATSPLEEFKRAAVPRFVQQKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWRYAPDKQAPGSDSQPRCVSEKWAPFVQENLLMYTKLFVGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIPHRQHRLFTAPTFTGSFLSPWPPAVTDASFKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAESPAGHSFLSWLGFSSMDTNGSYTANDLDEMGQDSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQLPDCIVGEDGLILTPLGRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINHRFAGQMAALCSRDDFLGSFCRYHLTEPGLASRHLLSPVGRRQVAGHTRGPRLSLRFLGSYRTLVSLLLAFFVASLFCVGPLPCTLLLTLGYVLYASAMTLLTERGKLHQP
What is the function of this protein?
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167).  It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489).  May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924).  In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity).
What are the official names of this protein?
Sphingomyelin phosphodiesterase 4, Neutral sphingomyelinase 3, nSMase-3, nSMase3, Neutral sphingomyelinase III.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Nucleus envelope. Cell membrane, sarcolemma.
Protein: ISPDF_CAMJR
Sequence: MSEMSLIMLAAGNSTRFNTKVKKQFLRLGNDPLWLYATKNLSSFYPFKKIVVTSSNITYMKKFTKNYEFIEGGDTRAESLKKALELIDSEFVMVSDVARVLVSKNLFDRLIENLDKADCITPALKVADTTLFDNEALQREKIKLIQTPQISKTKLLKKALDQNLEFTDDSTAIAAMGGKIWFVEGEENARKLTFKEDLKKLNLPTPSFEIFTGNGFDVHEFGENRPLLLAGVQIHPTMGLKAHSDGDVLAHSLTDAILGAAGLGDIGELYPDTDMKFKNANSMELLKQAYDKVREIGFELINIDICVMAQSPKLKDFKQAMQSNIAHTLDLDEFRINVKATTTEKLGFIGRKEGMAVLSSVNLKYFDWTRL
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: KAE1B_METMA
Sequence: MKKTFILGIEGTAWNLSAAIVTETEIIAEVTETYKPEKGGIHPREAAQHHAKYAAGVIKKLLAEAKQNGIEPSDLDGIAFSQGPGLGPCLRTVATAARMLGLSLGIPLIGVNHCIAHIEIGIWKTPAKDPVVLYVSGANSQVISYMEGRYRVFGETLDIGLGNALDKFARGAGLPHPGGPKIEAYAKEAKRYIPLPYVIKGMDLSFSGLSTAASEALRKASLEDVCYSYQETAFAMVVEVAERALAHTGKKEVLLAGGVGANTRLREMLNEMCEARGAKFYVPEKRFMGDNGTMIAYTGLLMYKSGNTISLEDSRVNPSFRTDDVKVTWIKEEEMKKVPEISPETFFRMPPGEILDNGAEAVVYLQEGPEGKRALVKERVPKAYRHKEIDERIRRERNRTEARLMSEARRAGVPTPIIYDVEEFKLKMQFIEGVPIKYLITPPLSEKVGELVGKLHSSGIVHGDLTTSNLLLAGERLYLIDFGLAYFDKSLEARGVDVHVLFQTFESTHRNYEALVKAFEKGYASTFIDSEDVLRRVEEIKKRARYA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  The Kae1 domain likely plays a direct catalytic role in this reaction.  The Bud32 domain probably displays kinase activity that regulates Kae1 function.
What are the official names of this protein?
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.