PharMolix/UniProtQA huggingface dataset:
Protein: EFG1_BURO1
Sequence: MPRKTPIERYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQGQERGITITSAATTAFWKGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYDSVGGVQPQSETVWRQANKYKVPRIAFVNKMDRIGADFFRVQKQIGERLKGVAVPIQIPIGAEDHFQGVVDLVKMKAIVWDDESQGVKFTYEDIPANLVELAHEWREKMVEAAAEASEELLEKYLHDHESLTEDEIKAALRQRTIANEIVPMLCGSAFKNKGVQAMLDAVIDYLPSPVDVPAILGHDFADPEKPAERHPSDDEPFSSLAFKIMTDPFVGQLIFFRVYSGVVESGDTVLNATKDKKERLGRILQMHANERKEIKEVRAGDIAAAVGLKEATTGDTLCDPQKPIILEKMEFPEPVISQAVEPKTKADQEKMGLALNRLAQEDPSFRVQTDEESGQTIISGMGELHLEILVDRMKREFGVEATVGKPQVAYRETVRTTAADVEGKFVKQSGGRGQYGHAVITLEPNPGKGYEFLDEIKGGVIPREFIPAVDKGITETLKSGVLAGYPVVDVKVHLTFGSYHDVDSNENAFRMAGSMAFKEAMRKAKPVLLEPMMAVEVETPEDFMGNVMGDLSSRRGIVQGMEDIAGGGGKLVRAEVPLAEMFGYSTSLRSATQGRATYTMEFKHYAETPANVSEAVINAKVK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 1, EF-G 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Protein: ILVC_ALIAD
Sequence: MEKIYYDADISIQPLADKRIAVIGYGSQGHAHAQNLRDSGFDVVIGLRPGSSWAKAEADGFRVMAVGEAVEESDVIMILLPDERQPAVYEREIRPYLTAGKALAFAHGFNIHFSQIQPPKDVDVFMVAPKGPGHLVRRVYEAGGGVPALIAVHQDASGQAKDLALAYARGIGAGRAGILTTTFREETETDLFGEQAVLCGGLSALIKAGFETLVEAGYQPEIAYFECLHEMKLIVDLIYEGGLEYMRYSISDTAQWGDFTSGPRIINEETKKEMRRILADIQSGAFAKSWILENQANRPMFNAINRRELEHPIEVVGRKLRSMMPFIKAKRPGDDRVPATADRA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: HMC2_DESVH
Sequence: MDRRRFLTLLGSAGLTATVATAGTAKAASTGTFPGYKDSYGVLHDTTRCIGCRKCEQACNEVNKLPAPKAKFDDLTVLEKTRRTDADSWTVVNRYNAAGLDHPVFRKQQCNHCLEPACASACFVKAFTKNPDGSVTYDGSLCVGCRYCMVACPFNVPAFQYAEAFDPLIQKCTMCHPRLAEGKLPGCVEICPKEALTFGRRKDLVRIAHDRIRQNPGRYIDHVYGEQEMGGTAWMYLSGVPFSATGMNEELGTKSAPEYTAGALGAVPMVVGIWPILLTGAYAITKRKEKIAAEEQAEAVKQAVAASRAEADDKLKAALAKADKDKEAAVTREVKKAVDEARKTFEEELAAKEQPEAPEGDDAGKPGEDA
What is the function of this protein?
HMWC (high-molecular-weight cytochrome c precursor), ORF2, ORF3, ORF4, ORF5, ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates.  ORF2 is a transmembrane redox protein.
What are the official names of this protein?
Protein DVU_0535, HMC operon ORF 2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RS12_PSEP1
Sequence: MATINQLVRQPRKRSVEKSDVPALQNCPQRRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVSSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGSLDTSGVKGRNQGRSKYGTKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: Y500_STAEQ
Sequence: MAKQAPDVGDYKYGFHDEDVSIFRSERGLTENIVTEISKMKEEPQWMLDFRLKALKLFYKMPMPQWGGDLSELDFDDITYYVKPSEHTERSWDEVPEEIKRTFDKLGIPEAEQKYLAGVSAQYESEVVYHNMEKELEEKGIIFKDTDSALRENEELFREYFASVVPAADNKFAALNSAVWSGGSFIYVPKNVKLDTPLQAYFRINSENMGQFERTLIIADEGASVNYVEGCTAPVYSTSSLHSAVVEIIVHKDAHVRYTTIQNWANNVYNLVTKRTFVHENGNMEWVDGNLGSKLTMKYPNCVLLGEGAKGSTLSIAFAGKGQVQDAGAKMIHKAPNTSSTIVSKSISKNGGKVIYRGIVHFGRKAKGARSNIECDTLILDNESTSDTIPYNEVFNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAVEMNRLIKFEMEGSIG
What are the official names of this protein?
UPF0051 protein SERP0500.
What is the protein family that this protein belongs to?
Belongs to the UPF0051 (ycf24) family.
Protein: SH2B1_RAT
Sequence: MNGAPSPEDGVFPSPPALPPPPPPSWQEFCESHARAAALDLARRFRLYLASHPQYAEPGAEAAFSGRFAELFLQHFEAEVARASGSLSPPVLAPLSPGVEIPPSHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGAVESPSQAGPLETTSGPPVLGGNSNSNSSGGAGTVGRALANDGTSPGERWTHRFERLRLSRGGGTLRDGAGVIQREELLSFMGAEEAAPDPAGVGRGGGAAGLTSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSTITDVRTATALEMPDRENTFVVKVEGPSEYILETTDALHVKAWVSDIQECLSPGPCPAISPRPMTLPLAPGTSFLTKDNTESLELPCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASFSPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSTPYPPLDTPEAATGSFLFQGEAEGGEGDQPLSGYPWFHGMLSRLKAAQLVLEGGTSSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSQRQQERSTSRDPTQPSEPPPWTDPPHPGAEEASGAPEVAAATAAAAKERQEKEKAGGGGVQEELVPMAELVPMAELEEAIAPGTEAQGGAGSSGDLEVSLMVQLQQLPLGGNGEEGGHPRAINNQYSFV
What is the function of this protein?
Adapter protein for several members of the tyrosine kinase receptor family.  Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs).  In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues.  These phosphotyrosines form potential binding sites for other signaling proteins.  GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1.  In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways.  In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2.  Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway.  Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity.  Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1.  For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2.  Enhances RET phosphorylation and kinase activity.  Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity).
What are the official names of this protein?
SH2B adapter protein 1, FceRI gamma-chain-interacting protein SH2-B, SH2 domain-containing protein 1B, SH2-B PH domain-containing signaling mediator 1.
What is the protein family that this protein belongs to?
Belongs to the SH2B adapter family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: VGB_CLOB8
Sequence: MNIKINEYYIPTSLSGPYGITAGIDEALWFTENKANKIGRITVKGEIEEYLVPSQDAGLSIIVSGTNGDLWFSEYNANKIGKITIKGEIVEYSIPTADSGPFGITEGPDGAIWFTELTGNKIGRISNLGEVIEYKLPNDSSYPSSIVCGSDGVLWFTENQGNKIGKITMLGEITEYTIPTIGSGPVGITSGPDGALWFVEINGNRIGRITTEGIINEYDLKTVKARPHAIITGSDGALWFTQWGSNQIGRITTSGEVSEYEIPTANSEPHGIAVGPDKAIWFAEECNKIGQLILL
What is the function of this protein?
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
What are the official names of this protein?
Virginiamycin B lyase, Streptogramin B lyase.
What is the protein family that this protein belongs to?
Belongs to the Vgb family.
Protein: POTA_MYCS5
Sequence: MQNNTTKSVKNNNVIELIDIVKQFDEKLVLDNVNLNIKRGEFVTLLGPSGSGKTTILRLIGGFEWATRGEIKFNGVDIKDLSPHKRNLSTIFQDYALFPHLNVEGNIMYGLKLKRVPKENVKKEHKNLLERKIKVWTEKAQREMKNLDKLQEEYENELKVLKPGTYKHQKRQTWLDDSDFKYSYWESYVLQKTEEFKNKYFKRKLTKEEIDQTVDKIVNLVGLQNNKNKKITELSGGMKQRVALARSLIIEPEILLLDEPLSALDAKIREKMQVFLKQIQQELKLTFIFVTHDQDEALELSDRIAVIREGKIEQYDTPKQIYDYPRNIWVAKFIGNSNIFNAKFLKDSKVELLNKEFKTIHDEDEFAVDEEVDALIRPEDIDIVNQTQNTEHKIKGKIVESIYRGSYYYIKVELKDSNYIFVETAKNFAVDETVYLSWTIDSIHLMKKDPKWDYAKKDF
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: VIF_BIV29
Sequence: MERTLQSVVGRRRGSSNRGRGKNSLISTPSYALHPPPRFRYPRWEFVRQTEYSMTACVRKGKLVLTYQYAIWKRVWTIETGFTDPSLFMTPAGTHTTEEIGHLDLFWLRYCSCPHEMPPWLDFLRGTLNLRISCRRALQASVLTSTPRHSLQRLAALQLCTNACLCWYPLGRINDTTPLWLNFSSGKEPTIQQLSGHP
What is the function of this protein?
Determines virus infectivity.
What are the official names of this protein?
Virion infectivity factor, Q protein.
What are the subcellular locations of this protein?
Host cytoplasm. Virion.
Protein: PYRH_MYCSS
Sequence: MSEPNSDHGAGAAVGETRPLYSRVLLKLGGEMFGGGAVGLDPDVVHLVARQIAEVVRSGVQVAVVIGGGNFFRGAQLQQRGMERTRSDYMGMLGTVMNSLALQDFLEKEGIDTRVQTAITMGQVAEPYIPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGAEVVLMAKAVDGVYTADPRKDPDAQLLTAITHREVIDRGLAVADATAFSLCMDNGMPILVFNLLVDGNIARAVAGEKIGTLVTT
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y673_GLOC7
Sequence: MKIQVKVKPNAKHQKIEEAEDGSLIISLKSPPVEGKANQELIKLLAQKYRVTKSQISIQSGLSSRNKLIEILD
What are the official names of this protein?
UPF0235 protein PCC7424_0673.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: K6PF_PYRAB
Sequence: MSVPQDVSIFTAYNANVDAITKLNGETIQKLINEFGEKEIAERIEEYPREIREPIDFVARLIHALRLGKPTAVPLVDESLNSWFDEKFEYELERLGGQAGIIANVLAGLGIKKVIAYTPFLPKRLADLFKEGVLYPTVENGELKLKPIREAYRDEDPLKINRIFEFRKGTKFKFLGESVEVPASGRFIVSARFESISKIETKEELRPFLDDIGKEVDGAIFSGYQGLRLKYSDGKDANYYLRRAKEDIISLKEEDVKVHVELASIQDRKLRKKVITNILPIADSVGIDEAEIAQLLSVLGYRDLADRIFTYNRLEDSILGGMIILDELNFEILQVHTIYYLMYITHRDNPLSEEELMKSLEFGTTLAAARASLGDINRPEDYEIGLKVPFNERSEYVKLRFEEAKTKLRMREYKVVVIPTRLVPNPVLTVGLGDTISAGAFITYVNYLKRH
What is the function of this protein?
Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
What are the official names of this protein?
ADP-specific phosphofructokinase, ADP-dependent phosphofructokinase, ADP-Pfk.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SOK2_NAJHA
Sequence: LECYQMSKVVTCKPEETFCYSDVFMPFRNHIVYTSGCSSYCRDGTGEKCCTTDRCNGARGG
What are the official names of this protein?
Weak toxin CM-2a.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group XX sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SESN_DROME
Sequence: MYYAVDYYADMGQISQDCFAATQTGASDFDMDELDDLDQVTQVIGYHPQFHDHFLATQNFIMKGDGPLPNDYRYYLAIIAAARHQCPYLVKRYEKEFINQGGDSAWLGGLDFIPAKLRAIYDINKILAHRPWLLRKEHIERLTKGKNSWSLSEVVHAMVLLSHFHSLSSFVFSCGLTQKLDGLSSPKLKSPPAAVAALAPTILITPTSPTEPQKGKPVLAEISLNNANPDYDSQTAASSNGGAPPDSANAVADGPDATTLNGYLATAQQLPQQHGISVETLMERMKVLSQKQDECSEAELSSRFQKVEQQTAELAAVTPEAAVGVPTNLSHYVDDANFIYQDFARRGTESINTFRIQDYSWEDHGYSLVDGLYNDVGIFLDAKFRAAYNLTYCTMGGIKNVDTSKFRRAIWNYIQCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSVLVELQDSEKVHVNLMIMEARNQAELLYALREIMRYMT
What is the function of this protein?
Functions as a negative feedback regulator of TOR function.
What are the official names of this protein?
Sestrin homolog, dSesn.
What is the protein family that this protein belongs to?
Belongs to the sestrin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: M3K14_HUMAN
Sequence: MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILNDVITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNNVAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQEDESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPHLSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
What is the function of this protein?
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.  Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway.  Could act in a receptor-selective manner.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_RICAE
Sequence: MIRFITIPDFADYQVTLKLMEDYVNKVISDHEPEIIYLVEHLEVYTAGTNYKQEELLNYGDIPVIYTGRGGKFTFHGPGQRVIYPILNLASPNRHKDLKLYIKMLEEWIINSLNYFGIKAYIIKDKVGIWVKVRKDEFAKIAAIGVRVRKWVTYHGVAINISTDLSKFSGIIPCGLENSLVTSLNQLGIHVEMSEFDKIIQTEFNKIFK
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_METEP
Sequence: MFDVQREELIWGDRKLVLETGKTARQADGSVVATYGETTVLATVVAGKEPKAGIDFLPLTVNYQERAYAAGRIPGGYFKREGRPSEKETLVSRLIDRPIRPLFVEGWRNDTQVVVTVLSHDLENDPDIVAMVAASAALTLSGVPFMGPIGAARVGYLNGGYKLNPLVTEIAESTLDLVVAGTQDAVLMVESEAKELSEDVMLGAVMFGHKHFQPVIEAIIRLAEKAAKEPRDFTPPENADVEAAVLAVAETELREAYKKTVKQERYAAVDAVKAKVVAALCPAEGEQKFSPEKVKAAFKEAQSKVVRWNILDTGSRIDGRDVKTVRSIVSEVGVLPRAHGSSLFTRGETQALVVATLGTGEDEQFIDALEGTYKERFLLHYNFPPYSVGETGRMGSPGRREIGHGKLAWRAIRPVLPPAHEFPYTIRVVSEITESNGSSSMASVCGGSLSLMDAGVPLRRPVAGIAMGLILEGERFAVLSDILGDEDHLGDMDFKVAGSEEGITSLQMDIKIAGITEEIMKIALAQAKDGRAHILGEMSKALTAARPELGEYAPRIETMQIPTDKIRDVIGTGGKIIREIVEKTGAKINIEDTGIVKIASSDGKAIKAAYNWIRSIVAEPEAGTIYDGTIVKIMEFGAFVNFFGAKDGLVHISELAAQRVAKVGDVVKEGQKVKVKFLGADERGKIRLSMKVVDQETGEDLTEKLKAERAERGEPEREERSDRGDRGDRGPRRDRGERRRESSGE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPMT_FELCA
Sequence: MDDTSTLTDVKEYPDTEVQKNRVLTLEEWREKWVDGKIGFHQEQGHQLLKKHLDTFLKGENVLRVFFPLCGKAVEMKWFADRGHCVVGVEISELGIREFFTEQNLSYSEEPIMEIPGAKVFKSSSGNISLYCCNLFDLPRVNIGKFDRIWDRGALVAVNPGDRKCYTDIMLSLTRKGFRYLLAVLSYDPTKHPGPPFYVPDAEIKNLFGSTCNIHCLEKVDVFEERHKSWGIDYIVEKLYLLTEK
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUKB_ECO7I
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLSERQARVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAIERQEENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADSAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQLVVAINGPLARNEAWDVARELLREGVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMTLRQEQEQLQSRIQSLMRRAPVWLAAQNSLNQLSEQCGEEFSSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRERLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQSVSFGQVNSVRLNVNVRETHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGTDEAPSQAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: MUKF_EDWI9
Sequence: MSDFSQTVPELVAWARKNDFALTLPTERLAFLLAIATLNGERLDGEMSEGDLVDVFRHVSKTFEQTHETVAQRANNAINDLVKQRLLNRFTSELAEGNAIYRLTPLGISISDYYIRQREFSTLRLSMQLSIVAQELRAAGDAAEEGGDEFHWQRNVFAPLKYSVAEIFDSIDLTQRLMDEQQQGVKRDIAGLLTQDWRAAISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATLGQEALGFVDKLVFDLQAKLDRIISWGQQAIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQGYLEAPWALTYANAERLLDMRDEELMLLNAEVTGELPPDLEFEEYSELRERLAALIEQELQVYRQEQRPLDLGRVLREYLARYPRQRHFDMARILVDQAVRLGVAEADFNGLQAQWQAINEYGAKVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: RPIA_METMP
Sequence: MARTKKANDEVATDSDSLKLKVAKQAAKLVKDEMVVGLGSGSTANLFIQELGKRVVEEELYIYGVPTSFDSRMMASNSGIPLISLDQCGEIDIAIDGADEVCKKTLSLIKGGGGCHTMEKIVDYHAKEFVVLADEGKLVESLGDKTAVPLEVIPFAYSTVLNKLLDMNTAPAIRSGSGKMGPVITDNGNMIIDVFINIEDAEETETMLNNIPGVLENGIFSKCDKVLVGTSKKVEILKK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: KHSE_ECOUT
Sequence: MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDTAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_MICAN
Sequence: MANVIVIGAQWGDEGKGKITDLLSRSADVVVRSQGGVNAGHTVVVEGQTFKLHLIPSGILYPDTECIIGSGTVIDPSVLLKEMAQLHALNVTTDNLYISQTAHVTMPYHRLLDQASEEKRGKYKIGTTGRGIGPTYADKSERIGIRVIDLINTENLRQKLEWTINYKNVILEKLYNLPPLDAKTVIEEYLEYAEILRPHVVDSSLKIYEAIRKRKNILFEGAQGTLLDLDHGTYPYVTSSNPIAGGACVGSGIGPTVIDRVIGVAKAYTTRVGEGPFPTELEGEIEQLLCDRGAEFGTTTGRRRRCGWFDAVIGRYAVRINGLDCLAITKLDVLDTLEEIKVCVAYQLDGQTCRHLPSSAGEFARCQPIYRTMPGWQQPTSDCRSLEDLPKQALDYLKFLGAIMEVPIAIISLGASRDQTIIVEDPIHGPKRALLDENGSPWDNHEF
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.