PharMolix/UniProtQA huggingface dataset:
Protein: RPOC_GLUOX
Sequence: MNELMKILGQTGQSVTFDQIKIQLASSEQVRSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKFRGIVCEKCGVEVTLAKVRRERMGHIELASPVAHIWFLKSLPSRIATMLDLPLKDVEPVLYFEKFLVLDKGVCESDQIDSYKNGKKRDQYLLDEIRCEDLLDEYPDAGIDVGIGAEAIKRALSSYDWGIPNDQERELSLAAKEKGLPDPFDYDADVMEGDSEKTMMRKKLRKATSEAARKKLVKRLKLVEAFVESGSRPDWMIMDIVPVIPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLIELRAPDIIVRNEKRMLQEAVDALFDNGRRGRAITGANKRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYSKLEKYGHATTIKAAKRMVEKERPEVWDILEEVIREHPVMLNRAPTLHRLGIQAFEPTLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLSLEAQLEARVLMMSTNNILSPANGKPIIVPSQDIVLGLYYLSLEVPEYRETPDEAVIKDGKIVTAAPPAYSDVAEIESAMLSGSLKLHDKIRLRLPTIDAEGKSVRQTILTTPGRALIAQILPKHQAIPFSLVNKQLTKKNVSDVIDTVYRHCGQKEAVIFCDRLMGLGFRHAARAGISFGKDDMIIPEAKATLVGKTSEEVKEFEQQYQDGLITAGERYNKVVDAWSRCTDEVQAAMLKEISKQVIGKPTNSVWMMSHSGARGSPAQMKQLAGMRGLMVKPSGEIIEQPIIANFKEGLSVLDYFTSSHGARKGLADTALKTANSGYLTRRLVDVAQDCIIVEPDCGTERGLTVRAVMDSGEVVASLSERILGRTLSKDVIHPVTQDVILPRNTLIEEAEAELIEKAGVESVDIRSVLTCDSRVGICAHCYGRDLARGTPVNIGEAVGVIAAQSIGEPGTQLTMRTFHIGGAATRGAEQSMVEASRDGIVTIKNRNVVENSQKVLVVMSRNCEILLTDENGVERARYRVPYGARLMVSEGEAVTRTQKMAEWDPYTLPIITEQAGTVEYLDLIDSITLVERMDEVTGLSSKVVVDYKQAAKGVDLRPRLQLKDASGNVVKLANGNDARYFLSPDSILSVENGAEVNAGDVLARIPREGSKTRDITGGLPRVAELFEARRPKDHAIIAEGEGRIEFGKDYKSKRCVIVKNDDTGEETQYLIPKGKHVSVQEGDFVQKGDPLVDGPRVPHDILKVMGVEALSDYLVNEIQDVYRLQGVKINDKHIEVIVRQMLQKVEILEPGDSTYLIGETVDRIEYEGENQRLMENGDTPAKAMPVLQGITKASLQTQSFISAASFQETTRVLTDAATSGKVDTLNGLKENVIVGRLIPAGTGSVMNRLRSIAASQDRQRVGGASPKAVEDAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PRPS3_HUMAN
Sequence: MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTSIADQLNVDFALIHKERKKANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAGATRVYAILTHGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILAEAIRRTHNGESVSYLFSHVPL
What is the function of this protein?
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase 3, Phosphoribosyl pyrophosphate synthase 1-like 1, PRPS1-like 1, Phosphoribosyl pyrophosphate synthase III, PRS-III.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family.
Protein: PSD_XYLF2
Sequence: MNFVTTLTYLLPHRMLSSLARHVAYCQHPLIKQWLIDTVIAKFDVNLSEAAEPDAHAYPSFNAFFTRSLKAGIRPPDPNPDTLLMPADGRISQLGPIREGRIFQAKGQSFTATELLGDTAAASAFTNGLFATVYLSPRDYHRVHMPCTGQLLKTVHVPGRLFSVGPDAVRQIPRLFARNERLVCHFDTTFGPMVLVMVGALLVSGVETVWGGVEIPAYGDRITYKDYQGRNIAIERFAEMARFNYGSTVIVLLPPNVLTLAPHLTAESPVTLGQALAHRLSLNHSTQAPTQEK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ISPG_SOLUE
Sequence: MAVKPRRNAVVVDVGGVKVGGTHPIVVQSMTNTDTADVASTVNQVMALARAGSELVRVTVNTEAAAAAVPKIVDACAAFGVRVPIIGDFHYNGHLLLKKYPECARALAKYRINPGNSDIGRKTDDNFRTMIEVAIENRKPVRIGVNWGSLDSALLTRMMDENSLLPEPKDAREVTLDAMVASAVQSARAAERHGLAHDQIILSAKVSGVQDLIDVYRALAAVCDYPLHLGLTEAGLGSKGIVATTAALAPVLQDGIGDTIRTSLTPMPNGDRTEEVIVSQQILQSLGIRSFTPQVTACPGCGRTTSTFFQEMADEIQTYLRVQMPSWKATHPGVETMKVAVMGCVVNGPGESKHSNIGISLPGTFEEPKAPVYVDGRLMTTLKGDRIVAEFLEILNEYVDTHYAIAGEPELVSGD
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: MT1A_PIG
Sequence: MDPNCSCPTGGSCSCAGSCTCKACRCTSCKKSCCSCCPAGCARCAQGCICKGASDKCSCCA
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
What are the official names of this protein?
Metallothionein-1A, MT-1A, Metallothionein-IA, MT-IA.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: PHOQ_SALTY
Sequence: MNKFARHFLPLSLRVRFLLATAGVVLVLSLAYGIVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKISVELPENLDMQSPTMTLIYDETGKLLWTQRNIPWLIKSIQPEWLKTNGFHEIETNVDATSTLLSEDHSAQEKLKEVREDDDDAEMTHSVAVNIYPATARMPQLTIVVVDTIPIELKRSYMVWSWFVYVLAANLLLVIPLLWIAAWWSLRPIEALAREVRELEDHHREMLNPETTRELTSLVRNLNQLLKSERERYNKYRTTLTDLTHSLKTPLAVLQSTLRSLRNEKMSVSKAEPVMLEQISRISQQIGYYLHRASMRGSGVLLSRELHPVAPLLDNLISALNKVYQRKGVNISMDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDDHLHIFVEDDGPGIPHSKRSLVFDRGQRADTLRPGQGVGLAVAREITEQYAGQIIASDSLLGGARMEVVFGRQHPTQKEE
What is the function of this protein?
Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides.  Essential for intramacrophage survival of S. typhimurium.  In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG).  In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG.  Essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system SsrB/SpiR (SsrA) and Pir at transcriptional and post-transcriptional levels respectively.  Promotes expression of the two-component regulatory system PmrA/PmrB via activation of pmrD gene.  Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells.  Negatively regulates prgH, which is required for invasion of epithelial cells.  Involved in acid tolerance.
What are the official names of this protein?
Virulence sensor histidine kinase PhoQ, Sensor histidine protein kinase/phosphatase PhoQ.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: C1GLT_CAEEL
Sequence: MANWPRVSPLAYVALGVLLGLTISIISQTGTTTYDAASRIAILRANRGDPQVDEHDHAHGNDPHGDEEVDDHHANFAPVQFHSNNSSHSHDGESLIADEVAKKVRVFCWILTGKQNHDKRAKHVKATWAKRCNKYVFMSSEEDAELPAINLNVSEGRDYLWAKTKGAFKYIYDHHLNDYDWFLKADDDTYVVMENLRFMLLAHSPDEPIHFGCKFKPFTQGGYHSGGAGYVLSREALKKFIEVALPDKSLCSQNHGGAEDAEMGKCLEKVGVKAGDSRDADGHHRFMPFVPEHHLSPGHVDPKFWFWQYTYYPMDQGPTCCSDYAVSFHYVNPNLMYVLEYLIYHLKPFGIDRAIRVPKNETIIHTAYSISRSERGQDDAFRDRPEVAV
What is the function of this protein?
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
What are the official names of this protein?
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, Core 1 O-glycan T-synthase, Ce-T-synthase, Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1, Core 1 beta1,3-galactosyltransferase 1, C1GalT1, Core 1 beta3-Gal-T1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: MPLKI_MOUSE
Sequence: MHRPNFRPPTPPYPSPGIGGWGGGNNFRGALGGGPRPPSPRDGYGSPHHTPPCGPRARPYGSSQSPRHGGNFSGARFGSPSPGGYPGSYSRSPAGSQHQFGYSPGQQQTYPQGSPRTSTPFGSGRGREKRMSNELESYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFS
What is the function of this protein?
May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.
What are the official names of this protein?
M-phase-specific PLK1-interacting protein, TTD non-photosensitive 1 protein homolog.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.
Protein: YABA_STAAM
Sequence: MDRNEIFEKIMRLEMNVNQLSKETSELKAHAVELVEENVALQLENDNLKKVLGNDEPTTIDTANSKPAKAVKKPLPSKDNLAILYGEGFHICKGELFGKHRHGEDCLFCLEVLSD
What is the function of this protein?
Involved in initiation control of chromosome replication.
What are the official names of this protein?
Initiation-control protein YabA.
What is the protein family that this protein belongs to?
Belongs to the YabA family.
Protein: GAG_WMSV
Sequence: MGQNNSTPLSLTLDHWKDVRTRAHNLSVKIRKGKWQTFCSSEWPTFGVGWPPEGTFNLSVIFAVKRIVFQETGGHPDQVPYIVVWQDLAQSPPPWVPPSAKIAVVSSPENTRGPSAGRPSAPPRPPIYPATDDLLLLSEPPPYPAALPPPLAPPAVGPAPGQAPDSSDPEGPAAGTRSRRARSPADDSGPDSTVILPLRAIGPPAEPNGLVPLQYWPFSSADLYNWKSNHPSFSENPAGLTGLLESLMFSHQPTWDDCQQLLQILFTTEERERILLEARKNVLGDNGAPTQLENLINEAFPLNRPQWDYNTAAGRERLLVYRRTLVAGLKGAARRPTNLAKVREVLQGPAEPPSVFLERLMEAYRRYTPFDPSEEGQQAAVAMAFIGQSAPDIKKKLQRLEGLQDYSLQDLVREAEKVYHKRETEEERQEREKKEAEERERRRDRRQEKNLTRILAAVVSERGSRDRQTGNLSNRARKTPRDGRPPLDKDQCAYCKEKGHWARECPQKKNVREAKVLALDD
What is the function of this protein?
Involved in the packaging and encapsidation of two copies of the genome.  Binds with high affinity to conserved elements within the packaging signal, located near the 5'-end of the genome.  This binding is dependent on genome dimerization.
What are the official names of this protein?
Gag polyprotein, Core polyprotein.
What are the subcellular locations of this protein?
[Gag polyprotein]: Virion. Host cell membrane; Lipid-anchor. Host late endosome membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. SUBCELLULAR LOCATION: [Matrix protein p15]: Virion. SUBCELLULAR LOCATION: [Capsid protein p30]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p10-Gag]: Virion. SUBCELLULAR LOCATION: [RNA-binding phosphoprotein p12]: Host cytoplasm. Note=Localizes to the host cytoplasm early in infection and binds to the mitotic chromosomes later on.
Protein: CHX8_ARATH
Sequence: MGGGDISHMSPEVKWIFEMAWYGETVRYDGLICEEHPPKLSSDGIWEKLIIKSAGLYFWQYRLPKLEIVILLVFFLWQGFNILFKKLGLSIPKLSSMMLAGLLLNVLVTLSGENSIIADILVTKNRIDVAGCLGSFGFLIFWFLKGVRMDVKRIFKAEAKARVTGVAAVTFPIVVGFLLFNLKSAKNRPLTFQEYDVMLLMESITSFSGIARLLRDLGMNHSSIGRVALSSALVSDIVGLLLLIANVSRSSATLADGLAILTEITLFLVIAFAVVRPIMFKIIKRKGEGRPIEDKYIHGVLVLVCLSCMYWEDLSQFPPLGAFFLGLAIPNGPPIGSALVERLESFNFGIILPLFLTAVMLRTDTTAWKGALTFFSGDDKKFAVASLVLLIFLLKLSVSVIVPYLYKMPLRDSIILALIMSHKGIIELSFYLFSLSLKLVTKDTFSILVLSIVLNSLLIPMAIGFLYDPSKQFICYQKRNLASMKNMGELKTLVCIHRPDHISSMINLLEASYQSEDSPLTCYVLHLVELRGQDVPTLISHKVQKLGVGAGNKYSENVILSFEHFHRSVCSSISIDTFTCIANANHMQDDICWLALDKAVTLIILPFHRTWSLDRTSIVSDVEAIRFLNVNVLKQAPCSVGILIERHLVNKKQEPHESLKVCVIFVGGKDDREALAFAKRMARQENVTLTVLRLLASGKSKDATGWDQMLDTVELRELIKSNNAGMVKEETSTIYLEQEILDGADTSMLLRSMAFDYDLFVVGRTCGENHEATKGIENWCEFEELGVIGDFLASPDFPSKTSVLVVQQQRTVANNN
What is the function of this protein?
May operate as a cation/H(+) antiporter.
What are the official names of this protein?
Cation/H(+) antiporter 8, Protein CATION/H+ EXCHANGER 8, AtCHX8.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DDX55_XENLA
Sequence: MENVTEGTWDSLPQKLNGSIRRTLEELKFTHMTPVQSATIPLFMNNKDIAAEAITGSGKTLAFVIPLLEILLKREEKLKKNQVGALIITPTRELAVQIDEVLSCFTKHFPQFSQILLIGGSNPVDDVRKFKEHGGNIIVATPGRLEDMFRRQADGLDLVICVKTLDVLILDEADRLLDMGFEASINTILGFLPKQRRTGLFSATQTQELENLVRAGLRNPVRIAVKEKGVAATSTQKTPIRLQNYYMICKADEKFNKLIAFLQKRKQEKHLVFFSTCACVEYYGKALEMLLKPVKVMCIHGKMKHKRNRIFTEFRKINSGILVCTDVMARGIDIHEVNWVVQYDPPSSASAFVHRCGRTARIGHHGSALVFLLPMEESYVSFLSINQKCPLQEMTELIISVDLLPKLKAMAETDRAVFEKGMKAFVSYVQAYAKHECNLIFRVKDLDFSSLARGFGLLRMPRMPELKGKNFSDFVSTLIDTDSIAYKDKNREKQRQKMLKERKEKLETEGRKHFAKNKAWSKQKARKEKKQKVALKRKKEEGSDIDEGDVDELLQDTRLLKRLKKGKITEEEFEKQLTAVGGKSEVEEGSEDSN
What is the function of this protein?
Probable ATP-binding RNA helicase.
What are the official names of this protein?
ATP-dependent RNA helicase DDX55, DEAD box protein 55.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Protein: PFF1_NEUCR
Sequence: MINPISFRPGPVTFWTTLIYLALLIPIVIINEKTPAAPKTAEPFKGVNLTEAWLDLTTITRAYHPYNSKFNEEVRRYLLEKVETILEENGASWVSDGQMTTVKDGKSAAVTVFDDNVSNSTFVMGKSNGTTFTRTDSINNAAYFEGTNILVYIRGKEDDEGEWWEADYAHGMRRNAKGLTLVNAHYDSVSTGFGATDDGMGVVTALQVLKYFTAPGHQPQRGIVVMLNNGEEDWLYGAHALGQHKLNPFIHTFLNLEGAGAGGRAIVFRATDREVMAAYARTSHPFGTVIASDAFGLGFISSGTDYSVLVDAYGQRGIDLAFFKPRARYHTNQDDTRHTSKGSLWHMLSAAIHTTKQFSGDTGNTFIGQRPDKAHGKVANGRSSNGVWFDLFGKSFVLFGLRGMFAWSLTLLIATPLVLVGITWLLRNLDKDYFFTSTVKTKEHPEYEAVPIGGWKGFFRFPFALGVAVFFTISSALLMNKVNPLIVYSSRYSVWVMMVSIFYFSFWMIMRGANFVRPSALHRGYANLWLFVFGWIVLVAVTALEDRRRIAAGYIFVFLESAIFLSCLISFVELLAVPRKSSYALQVQEDYDGQEHDHNGYQGFRDSTDEPSLRARAESSASAASPPSPTVAQEPSKSKAPAGTTNGLSTAPSVAAHSSQPQPAPTTPIPGRSSGAPSTASRDENESEDDDEPTERTPLVGGNGTNDRGRTTFATTYRRSITALVHGARKMEEDGEPYDHEQEWSGHLPSWAWFFQFLLLGPFMIILAAQTGLMLTDAVYQTGSDGSKLITPYLIIFVFTVLLILPLTPFIHRVTHHIPVFLLVVFIVTLTYNLIAFPFSANNRYKTFFGQYIDVATGDNKVCYTGIEEYVRPIIAELPSASGREVTCGKSLRRGSTISTCCFDGSAVPPKLGSEDDNGLPEDSYADLITINATRSTKRGDSSRTTARIEITADNTKSCFLQFKKPVSALAIENGSGWDDRFGQYPEDGVGLVRLWHREFGKTWVVNAEWKGSETRKEYDENDGTVICMWSDANTPGTIPALDEALQFVPSWAAVTKFSEGLVEGRKAFKIV
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: HIS4_SYNE7
Sequence: MDVIPAIDLLGGQCVRLFQGDYDQAEVYGKDPVGMALRWAEAGAQRLHLVDLDGAKEGSPVNAEAIATIAQRLSIPVQVGGGLRDRDTVARLLDSGVERAILGTVAVERPALVEALAGEFPGQIAVGIDARSGKVATRGWLEDSGLTAVALAQQMADLGACALICTDIGRDGTLQGPNLEELRAIAAAVSIPVIASGGVGSLTDLLSLLPLEAQGVSGVIVGKALYTGAVDLQEALRAIGSGRWQDVAVDDSSRLA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNX5_HUMAN
Sequence: MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
What is the function of this protein?
Involved in several stages of intracellular trafficking.  Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769).  Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable).  Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988).  Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235).  May function as link between endosomal transport vesicles and dynactin (Probable).  Plays a role in the internalization of EGFR after EGF stimulation (Probable).  Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387).  Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable).  Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942).  Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941).
What are the official names of this protein?
Sorting nexin-5.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Endosome. Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation.
Protein: ANTDB_ACIAD
Sequence: MSLELHFAVSQFLYKKAELCDNYDWDAYIDLYDEDSEYHIPQWIDDHNYVQDPNQGLSYIYYEDRSGLEDRVFRIRTGKAASATPLPRTQHNIHNVQVKTLEDGLIEAKVSWRTLYNRQGLEGCFYGRATYVLRPTEDSFRIRRQHSVLLNDKIDSVLDFYHV
What is the function of this protein?
Component of anthranilate dioxygenase multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into anthranilate to form catechol.
What are the official names of this protein?
Anthranilate 1,2-dioxygenase small subunit.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
Protein: HAD_PSEFL
Sequence: MKNIQGAVFDLYGTLYDVNSVAQVCEEVYSGHGDSISRLWRQKQLEYTWLRSLMGRYVNFEKATEDALRFTCTHLGLSLDDETHQRLSDAYLHLTPYADTADALRRLKAAGLPVGIISNGSHCSIEQVVTNSEMNWAFDQLISVEDVQVFKPDSRVYSLAEKRMGFPKENILFVSSNAWDASAASNFGFPVCWINRQNGAFDELDAKPTHVVRNLAEMSNWLVNSLD
What is the function of this protein?
Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.  Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-2.  Active with 2-halogenated carboxylic acids and converts only the S-isomer (or L-isomer) of 2-chloropropionic acid with inversion of configuration to produce R-lactate (or D-isomer).
What are the official names of this protein?
(S)-2-haloacid dehalogenase, 2-haloalkanoic acid dehalogenase, Halocarboxylic acid halidohydrolase, L-2-haloacid dehalogenase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
Protein: UBIC2_PSEPF
Sequence: MQHTNAPLWRPQSELTPLPDTSTLDWLFDEGSLTRRLTHLSDDGFSVTPLFEGWQTLRDDECAALDLAEGSEGWVREVYLRGHGQAWVFARSVASRSALQGDGLHMDELGSRSLGELLFCDHAFQRRAIEVCHYPEHWLPEGSRAAGLWGRRSRFDRGALSVLVAEIFLPTLWEAVRARPENC
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase 2, CL 2, CPL 2.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASPG1_ARATH
Sequence: MAFPRFLSLLAVVTLSLFLTTTDASSRSLSTPPKTNVLDVVSSLQQTQTILSLDPTRSSLTTTKPESLSDPVFFNSSSPLSLELHSRDTFVASQHKDYKSLTLSRLERDSSRVAGIVAKIRFAVEGVDRSDLKPVYNEDTRYQTEDLTTPVVSGASQGSGEYFSRIGVGTPAKEMYLVLDTGSDVNWIQCEPCADCYQQSDPVFNPTSSSTYKSLTCSAPQCSLLETSACRSNKCLYQVSYGDGSFTVGELATDTVTFGNSGKINNVALGCGHDNEGLFTGAAGLLGLGGGVLSITNQMKATSFSYCLVDRDSGKSSSLDFNSVQLGGGDATAPLLRNKKIDTFYYVGLSGFSVGGEKVVLPDAIFDVDASGSGGVILDCGTAVTRLQTQAYNSLRDAFLKLTVNLKKGSSSISLFDTCYDFSSLSTVKVPTVAFHFTGGKSLDLPAKNYLIPVDDSGTFCFAFAPTSSSLSIIGNVQQQGTRITYDLSKNVIGLSGNKC
What is the function of this protein?
Aspartic protease involved in drought avoidance through abscisic acid signaling.
What are the official names of this protein?
Protein ASPARTIC PROTEASE IN GUARD CELL 1, AtASPG1.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: PTK6_HUMAN
Sequence: MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
What is the function of this protein?
Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.
What are the official names of this protein?
Protein-tyrosine kinase 6, Breast tumor kinase, Tyrosine-protein kinase BRK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell projection, ruffle. Membrane. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
Protein: UVRC_NITMU
Sequence: MQAEPAFDAKAFCAGLPSQPGVYRMMNSAGQVIYVGKAIDLKKRVSSYFQKNGLAPRTQLMVSQIAGIETTVTRSEAEALLLENNLIKSLNPRYNILFRDDKSYPYVILSGHRFPRLGFHRGPLDKKHHYFGPFPNAGMVRESIQLLQKVFRIRTCEDSVFSNRTRPCLLYQIKRCSGPCVDLVSEEVYAEDARDAELFLQGKQTEVLKSITRKMHEAAEEQEYEQAALFRDQIQSLRKICERQFVDSGRALDADIVACVAENNGGGRVCVNLAMVRGGRHLGDKSFFPQNAEGYDLATVAEAFLAQHYLNRSIPDLIIVGERVPRESLQALLTQQAGHKVIINVNPIGSRRVWLEMATENAALALEQMLGRQASQEERLLALQQALDMTGLSRIECFDISHTMGEATIASCVVYDNFGMRNSEYRRYNITDITPGDDYAAMRDVLSRRYHKIAEGEGNLPDLILIDGGRGQINAALEVMVELGLNDANLVGVAKGEERKPGLEQLIFPGVKKPLQLSKDHPGLHLIQQIRDEAHRFAIYGHRAKLGKARVSSSLEQIAGIGAKRRQSLLARFGGLKGVRTASIEELQQADGISRALAEKIYRELH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_BRUA1
Sequence: MIEHNPTTIYGTTIVTVRKDGKVVIAGDGQVSLGNTVMKGNARKVRRIGKGNVIAGFAGTTADAFTLLERLEAKLEQYPDQLMRASVELAKDWRTDRYLRKLEAMMLVADSKVTLALTGTGDVLEPEQGVMAIGSGGNYALAAARALIETDKSAEEIARKAMNIAADICIYTNHNIIVESLDAQ
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.