PharMolix/UniProtQA huggingface dataset:
Protein: RPO2_THECE
Sequence: MASRGPTVVDVTPDDLWLVMEAYWKEKGLVRQHLDSYNAFIDHGMQEVIDEFGGVKPDIPDFEVKFGKVRLGEPEFQEAQGQRKPLYPMDARIRNLTYSAPIYLELIPVVNGVSQEAVEVRIGELPIMLKSKACRLYGLSDEELIKLGEDPKDPGGYFIVNGSERVIVSIEDLAPNKTLVERDERQNRIIAKCFSYRHGYRALITVERRKDGILYVKLPNVPRPVKFVYVMRALGLLSDREIVEAVSDDPRIQHVLFDNLEDASDVTTQEEALDYIGKLSLPGQPKEYRLRRAQNIIDNNLLPHMGVEEKDRKAKAYYLGMMALRVLELSLGLRGEDDKDHYANKRLKLAGDLLMDLFRVAFGQLVKDMQYQMTKTYQRKGERYTFENIQRFVRNSIRPDVLSERIEHALATGSWPGGRTGVSQLLDRTNYISTLSHLRRVTSPLSREQPHFEARDLHGTHWGRICPTETPEGPNCGLVKNLALMSQITTGVPEEEVREYLERLGVVPIEERRPNPDLWRLYLNGVLVGTVEDGEGFVNRIRTDRRSGKISDIINVALYQDEDVKEIYVNSDDGRVRRPLIIVENGRPKLTREHVEAIKNGSLTWSDLVKMGVIEYLDAEEEENALVATWPWEVTEEHTHLELMPAAILGIPASLVPYPEHNARPRNTYGAGMAKQSLGLGWANFRIRVDTRGHLMHYPQVPLVNSRIMKAVGFEERPAGQNFVVAVLSYAGYNMEDAIIMNKASIERGLARSTFFRTYEAEEKRYLGGQTDRFEIPDPTIQGYLGERYYRHLDEDGIIFPESKVNGKDVLVGRTSPPRFLEEQSGLGGIILQERRETSLTVRPSETGVVDKVIITETGDGTKLVKVTTRDLRIPEFGDKFASRHGQKGVIGLIVPQEDMPWTESGIVPDLIVNPHGIPSRMTVGQLIEAIGGKVASLKGRRVDGTAFIGEPEEKLRKELEELGFKHSGREVMYDGITGRRLEADVFVGVIYYQRLHHMVADKMHARSRGPVQVLTKQPTEGRAREGGLRFGEMERDVLIGHGAAMLLIERLLEESDKTEVWVCENCGHIALEDKRRGKVYCPVCGEEERISKVEMSYAFKLLLDELKAMGIRPSLKLVDRV
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  This subunit is involved in DNA promoter recognition.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo2, DNA-directed RNA polymerase subunit B.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_XANCB
Sequence: MSIVRMTDLDLSGKRVLIRQDLNVPIDNGQITSEQRITASVPTIKLALEKGAAVMVTSHLGRPKEGTWSEEDSLAPVAARLTTLLGLDVPLVRDWVDGVDVAPGQVVLLENCRMNVGEGKDDEALARKYAALCDVFVMDAFGTAHRAQASTHGVIRFAPVAAGGPLLMAELDALAKALDNPAKPLLAIVAGSKVSTKLELLSNLVNKVDQLIVGGGIANTFIAAAGHDVGKSLSEPDLIPTANQIVADAKARGAEIPLPTDVVVAKQFLPDAEASVKSLDQVDADDLILDIGPQTAAHYAELIANAGTVVWNGPVGVFEFEPFSHGTETLARAIAASKAFSIAGGGDTLAAVDKYAIAKDVTYISTGGGAFLEFLEGKTLPAVAALEARGQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBA_RHIUN
Sequence: VLSPTDKTNVKTAWSHVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKAHGKKVGDALTQAVGHLDDLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLALHNPQDFTPAVHASLDKFLSNVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ATG9_SCHPO
Sequence: MFYQPAQNKKQYDDLADIEAQNNVPNTQEVLEAWQESLDSDEDESSPLEESNGFTISEHDDFVKSVPRKNNPTDLLYSGKLLDSDEPPSVHGNSSKVPSKHPSPSFPETTSLRNLQNGSKQKPALPNFNDPHFYNEDVTRSGHPNRSIYTQLPRNEFSNARVLWNRLSARDRVLWRWANVENLDSFLQQVYTYYTGKGLSCIIVHRLFQILTVSFVIGFTTFITSCIDWPAVTPHGSLAGVTKSQCIAQMSPITYLVLWLFLSFLLALWIYYLTDIPRLWQMREFYIHALKIATADMPTVSWQRVLYRLLKLKNVNALTAEDGRVVSLHNMKRLDAYAIANRIMRKDNYFIALINNGIINIELPLLHRRILTHTTEWNINWCIFNFVFDEQGQLRSAFRNPNSRKRLSEELRRRFIVAGFLNCLFAPIVAIYLVIHNFFRYFNEYHKNPGALSTRRYTPLALWTFREYNELQHFFDERINDSYAAASHYVSQFPDFNMIRLFKYISFILGSFTAILVIITVFDPELMVTFEITKDRSVLFYLGLFGSLIAVSRSIIPDETLVFAPEKALRRVITFTHYMPGWWSDNMHSKAVQQEFCSLYSYRIVNLLWEILGILLTPVLLFFTFPSCSQDIVDFFREHTINVEGVGYVCSYAVFQDNPPYESVASLVQSRKISPLIQNKPELSRISFYEQFNTEAPRRDLR
What is the function of this protein?
Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation (PubMed:23950735).  Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (By similarity).  Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through atg2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity).  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).  Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking (By similarity).  Has a role in meiosis and sporulation (PubMed:19778961).
What are the official names of this protein?
Autophagy-related protein 9.
What is the protein family that this protein belongs to?
Belongs to the ATG9 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HFQ_SHESH
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQVESFDQFVILLKNTVSQMVYKHAISTVVPARPFNVNSHTAAPSPAGGFNGQQDDNNDQ
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: ISPF_FUSNN
Sequence: MLRIGNGYDVHKLVEGRKLMLGGVEVPHTKGVLGHSDGDVLLHAITDAIIGALGLGDIGLHFPDNDENLKDIDSAILLKKINNIMKEKNYKIVNLDSIIVMQKPKLRPYIDSIRDNIAKILEINSELINVKAKTEEKLGFTGDETGVKSYCVVLLEKKKC
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: YEIH_ECOLI
Sequence: MTNITLQKQHRTLWHFIPGLALSAVITGVALWGGSIPAVAGAGFSALTLAILLGMVLGNTIYPHIWKSCDGGVLFAKQYLLRLGIILYGFRLTFSQIADVGISGIIIDVLTLSSTFLLACFLGQKVFGLDKHTSWLIGAGSSICGAAAVLATEPVVKAEASKVTVAVATVVIFGTVAIFLYPAIYPLMSQWFSPETFGIYIGSTVHEVAQVVAAGHAISPDAENAAVISKMLRVMMLAPFLILLAARVKQLSGANSGEKSKITIPWFAILFIVVAIFNSFHLLPQSVVNMLVTLDTFLLAMAMAALGLTTHVSALKKAGAKPLLMALVLFAWLIVGGGAINYVIQSVIA
What are the official names of this protein?
UPF0324 inner membrane protein YeiH.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FGF8_CHICK
Sequence: MDPCSSLFSYVFMHLFVLCLQAQVTVQSPPNFTQHVREQSLVTDQLSRRLVRTYQLYSRTSGKHVQILDNKKINAMAEDGDVHAKLIVETDTFGSRVRIKGAATGFYICMNKKGKLIGKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQREVHFMKRLPKGHQTTEPHRRFEFLNYPFNRRSKRTRNSSASLRP
What is the function of this protein?
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration.  Involved in initiation, outgrowth and patterning of the limbs.
What are the official names of this protein?
Fibroblast growth factor 8, FGF-8, Heparin-binding growth factor 8, HBGF-8.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYFA_DEIDV
Sequence: MQQQAISEIQAAETLDALQAVKTKYVGKSGLVTRELGSLGKLPPEERKARGAEINTVRQAIDAALTEREGVLKRAALDARLASEAIDVTLPGLPLPAGGLHPINRVYEDLTGIYERMGYAVIEGPEVEDEHHNFEALNVPWYHPARDLQDTFWLEDGRLLRTHTSPMQIRYMVDHEPPLKIVVRGKVYRYEATDATHEAMFHQLEGLVVGDGISMADLKGTIAEMARGLYGPSAKVRFQPSYYPFVEPGADFAVWWDNPRGESKWLELGGCGMVHPNVFRAVDDLREAQGKPRIYEGKTGFAFGLGPERIAMLKYGIPDIRYFYANDPRVIGQFRGELG
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA1_FRATW
Sequence: MTNNTDKQTLKKLERQILRKTAQAINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFPEEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNGSIKAMPAKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKALSNISPSQMLDKELFDFINISKDDIQR
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase 1, Two-thiocytidine biosynthesis protein A 1, tRNA 2-thiocytidine biosynthesis protein TtcA 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_STRPS
Sequence: MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLVINQPFAVTSTVGSYDVFVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAGLLTRDSRKVERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: SLX4_DROME
Sequence: MDRKTRRANFKNLQPRLTRSTKAAADTLSLSNFFATPENAEEVPSCLADIPVQPDPPAPKIKPIRTSNVFEKPGPKPKKAPKLKASTVSTSSGARRGRGKSKQQPSISNFLRNEQIFAEVTAQHCMADNFSADDIEMALALSKSESEKHGRLRLHDDDDAVVDLLDDEEKSTERIRHKLQKYGFRTAAKEDYKSLAVLPVVASKGGRRGKWANRFTSLTLRNPDVQQKKLEEKVSALLGQEMRGKEPNGEDCCLTPYTVITAALKELRAEGESRILREPSEGPIDDLESYYVTDLFEVSRTPAHHLLKNWAAIQGRDFSPERETQKCRQLRQQHELVYAELERYYGDPQKLEEEVMQELDELEKLVADNMIEDDSVVINIVEAESSSTGSSPSKEPPDKRPKMTMEDKENLQPTTSKASLTVPAQSTRCTSPDLFADSEDEPDIVTTAISNEPEDVRNLSMKVYKNVSISERSSSVAEIEIVSSNDEPSQITTYEVFSSDEVKTVSNATQEKISFDDDFIDLTQEFDMVEFNESKPRTPNLIASSETDSNVDNLNGDTILDFSSQEVSCPISKELYAKYAKVETFPVWNAAAEEEDKIEFSLSMERDLKSSEQSSHQLGILTTPNDTEHSSSFSELNFSRNSLRRSVSLSTDLSFKSPLNWKMNSSAEKRVSPAASPYKQSDASVDLTQNSDDENDAILLSDEEINYSIWKGNKTVKDLDIGDDSSDSCFASPVTKKRAIPQFQTEEDLDAFLMDFSTDGNGSQGSHSPNKSALSKERAEFGILDAAPSQPFSLSELQSHADKEKSSDNEINWAEASFLDAPAKPLSRRSSHKFNELLAKISKPAHNSGDDFDEFDQMVFQSTKEAASSAGETSDMPQGLDLLLKGEIKTTAIPETRAPGNQTPIEPQQVDVDGNVYSVRVCHTPKPDFATLPESEILQQLYKYGIKPLKRKQAVKMLEFIYNQTHPIMKTAAVQDLPARSEPIVRSKSTPVIMERPHSQVAKSTSKTLKAIGTKKDLTFNDATGEELLRFSQSLAPSLCDDFETFVMQTNVTKKTPQPLVPLHIAWHNLICANPQLHESVLTYEPIDLQAVYLHLKHMGHRYDPKDLKTFFDRRCIIFRYELGAPGKQAERHVRRHTKKPSKRK
What is the function of this protein?
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases.  Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage (By similarity).  Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity).  Interacts with the structure-specific MEI-9-ERCC1 endonuclease to generate meiotic crossovers.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX4, Mutagen-sensitive protein 312.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DDX20_HUMAN
Sequence: MAAAFEASGALAAVATAMPAEHVAVQVPAPEPTPGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSDPSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPIPSGLMEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNNSVSGLSVKSKNNTKQKLPVKSHSECGIIEKATSPKELGCDRQSEEQMKNSVQTPVENSTNSQHQVKEALPVSLPQIPCLSSFKIHQPYTLTFAELVEDYEHYIKEGLEKPVEIIRHYTGPGDQTVNPQNGFVRNKVIEQRVPVLASSSQSGDSESDSDSYSSRTSSQSKGNKSYLEGSSDNQLKDSESTPVDDRISLEQPPNGSDTPNPEKYQESPGIQMKTRLKEGASQRAKQSRRNLPRRSSFRLQTEAQEDDWYDCHREIRLSFSDTYQDYEEYWRAYYRAWQEYYAAASHSYYWNAQRHPSWMAAYHMNTIYLQEMMHSNQ
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.  May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX20, Component of gems 3, DEAD box protein 20, DEAD box protein DP 103, Gemin-3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).
Protein: ST7_MUNMU
Sequence: MAEAGTGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAMIDIFCSAEFRDWNCESIFMRVEDELEIPPAPQSQHFQN
What are the official names of this protein?
Suppressor of tumorigenicity 7 protein.
What is the protein family that this protein belongs to?
Belongs to the ST7 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL15_ECO45
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PURQ_PYRAE
Sequence: MRIAVLKFPGTNGDYDVLRALELAGARGELVWYRDYAAGKYDAVVLAGGFSYGDRLRAGAIAAATKAMDHVREDAERGVPVLGICNGFQILTEAGLLPGALIPNDPPGFISRWVAVRVVDTRTPFTYLYEEGEVVYMPIAHGEGRYVPAGEYKAAFKYVDNPNGSYDNVAGVYEKNVLGLMPHPERAVDPHVSRRGAGGLKLWLGLISWLRR
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_AZOC5
Sequence: MNIIQQLEAEQAARLSETKTIPEFQPGDTVIVNVKVVEGERTRVQAYEGVCIARNGGGLNENFVVRKISYGEGVERVFPIYSPLIDSIKVVRRGKVRRAKLYYLRDRRGKSARIAERTDDRAKKAKATAAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: PUR4_PHOLL
Sequence: MKILRGSPALSAFRITKLLSVCQEQQLPVNDIYAEYVHFAEINASLSDVDSAKLQQLLKYGPSLAEHEPQGTLLLVTPRPGTISPWSSKATDIAHNCGLSQVVRLERGVAYYIQSGEMSDTQWQILSSLLHDRMMETVFTQLEQAEKLFSRQQPVPLKRIDILQAGRSALETANIELGLALASDEIDYLMDAFQKLGRNPTDVELYMFAQANSEHCRHKIFNADWIIDSQAQPKSLFKMIKNTYEQTPDYVLSAYKDNAAVMEGSAVGRFFASAENGSYDYHQEQAHILMKVETHNHPTAISPWPGASTGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEEDFGKPERIVSALDIMMEGPLGGAAFNNEFGRPALLGYFRTYEEKVNSHNGSELRGYHKPIMLAGGIGNIRDEHVKKGEISVGAKLIVLGGPSMNIGLGGGAASSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQLGENNPILFIHDVGAGGLSNAMPELVSDGGRGGRFELRKILNDEPGMSPLEVWCNESQERYVLAVAPEQLPLFEEICRRERAPYAIIGEATEERHLLLNDEHFDNQPIDMPLDVLLGKTPKMLRDVTTLKASGESLERRDIDLAEAVKRIMHLPAVAEKTFLITIGDRSVTGMVSRDQMVGPWQIPVADCAVTTASLDSYYGEAMSMGERAPVALLDFAASARMAVGEALTNIASAYIQDLKRIKLSANWMSAAGHPGEDAGLYAAVKAVGEELCPALGLTIPVGKDSMSMKTRWHDQGEEREMTAPLSLVITAFARVEDVRRTVTPELSTDEDNALLLIDLGQGKNTLGGTALAQVYRLLGNKTADVRSAEQLAGFFNAIQQLIAEQKLLAYHDRSDGGLLVTLAEMAFAGHCGIEADISVFDEDILAGLFTEELGAVVQIRASDRGFVESILAEHGLADCVHYLGKAQAGDDFVIFSGNTEVYRQNRSTLRLWWAETTWQMQRLRDNPACADQEHQAKQDNQDPGLNVKLTFDISEDIAAPYILQQVRPKVAVLREQGVNSHVEMAAAFHRAGFEAIDVHMSDLLSGRIGLSQFQTLVACGGFSYGDVLGAGEGWAKSILFNERVRDQFAVFFARPDTLALGVCNGCQMMSNLRELIPGAEHWPRFVRNRSERFEARFSLVEITDSPSLFLQDMVGSRIPIAVSHGEGQVEFRNRQHLEMLESNQLVALRYVNNYGQVTENYPANPNGSVNGITAVTSLDGRATVMMPHPERVSRTVNNSWHPDEWREDGPWMRIFRNARKQLG
What is the function of this protein?
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_AQUAE
Sequence: MKKVRKLYEGKAKIVYETDEKDKLILEFKDVATAFDGVKKEEIKGKGSLNNEISSLIFEILEDHGIKTHYIKKLSDREMLVWRAERFPVEVVVRNYAAGSFVKRYGVKEGTKLEQPLVEFFMKSDELHDPMVCINHIKVLKLAPAELVPEMEKIALKVNEILKKIFEEKGILLVDFKLEFGRLPSGELAIVDEISPDSMRLWDKSTGENWIKTDSV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: ARI4A_MOUSE
Sequence: MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPLRVGAIVETRTSDGSIQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLTNPEHFGTPVIAKKTNRGRRSSLPITEDEKEEESSEEEDEDKRRLNDELLGKVVSVASTAESTGWYPALVVSPSCNDDVTVKKDQCLVRSFIDSKFYSIARKDIKELDILTLPESELCARPGLRRASVFLKGRIVPDNWKMDISEILESSSSDDEECPAEEHEEEKEKEAKKEEEELPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCGNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTIHHHEPKVKEEKKDFEDSMDEALKEAPEMPLLDVKSEPEENTDSNSESDREDTELKSPRGRRKIVRDANCIKKEIEEEKIEDKFLRDDLENKDAGDDDDDGDPAAKREHELLFGRKSTPKNKEKKIKKPEDSERDSDEEEEKSQEREETESRCDSEGEDEEDDTEPCLTGTKVKVKYGRGKTQKIYEASIKSTEMDDGEILYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKVKNKEDSEKDEKRDEERQKSKRGRPPLKSTFSPNMPYSLSKTSNSEGKSDSCSSDSEADDQLEKSSGGEDLSPDVKEELEKNENAHDDKLDEENPKIVHISKENDRTQAQPSDTLTVEAGDSDQIVHIFGDKVDQVEEFKKQVEKSPKGKGRRSKTKDLSLELIKISPFGQEEAGSEAHGDVHSLEFSSLECKNFSSTEDDIDPYEKEKKLKRKILGQQSPEKKLRLDNGMEMTTGVSQERSDDGAGAEGMKGAHVEQHFETEGEGMPSLTAEPDQGLQELTSEKSDSPAEEEPVHTPLKEEEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVVVEGSESNSLASVPPALPPVAQHNFSVASPLTLSQDESRSIKSESDITIEVDSIAEESQEGLCERESANGFEASVASGACSIIAHERESREKGQKRPSDGNSGLIAKKQKRTPKRTSAAAKTEKNGAGQSSDSEDLPAMDSSSNCTPVKRLTLPKSQKLPRSPARTSPHIKDAEKEKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR
What is the function of this protein?
DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (PubMed:17043311, PubMed:23487765).  May function as part of an mSin3A repressor complex (By similarity).  Has no intrinsic transcriptional activity (PubMed:23487765).  Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (PubMed:17043311).  Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation (PubMed:23487765).  Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765).  Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis (PubMed:18728284).  May function as a leukemia suppressor (PubMed:18728284).
What are the official names of this protein?
AT-rich interactive domain-containing protein 4A, ARID domain-containing protein 4A, Retinoblastoma-binding protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS8_SALAI
Sequence: MTMTDPIADMLTRLRNANQAYHDRVTMPYSKIKANIAEVLKAEGYISTWLVEEPEESVVGKRLVVELKYGQNRERSLAGIKRVSKPGLRVYAKSGELPRVLGGLGVAIISTSQGLLTDRQARKRSVGGEVLAFVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: L2HDH_MOUSE
Sequence: MWPTLRYVGGVCGLARYCVAGGFLRASGPASGVPGLLCGGGRRSSSTSSFDIVIVGGGIVGLASARTLILKHPGLSIGVVEKEKDLALHQTGHNSGVIHSGIYYKPESLKAKLCVEGAALIYEYCNLKGIPYRQCGKLIVAVEQEEIPRLQALYERGLQNGVEGLRLIQQEDIKKKEPYCRGLMAIDCPYTGIVNYQQVALSFAQDFQEAGGSILRDFEVKGIEIAKENSSRSKDGMNYPIAVKNSKGKEIRCRYVVTCAGLYSDRISELSGCNPDPQIVPFRGDYLVLKPEKGYLVKGNIYPVPDSRFPFLGVHFTPRLDGTIWLGPNAVLAFKREGYRPFDFDARDVMEVILKSGFINLVFQHFSYGVNEMYKACFLSETVKHLQKFIPEITISDVLRGPAGVRAQALDRDGNLVEDFVFDGGTGEIADRVLHVRNAPSPAATSSLAISRMIAEEAQQRFKL
What are the official names of this protein?
L-2-hydroxyglutarate dehydrogenase, mitochondrial, Duranin.
What is the protein family that this protein belongs to?
Belongs to the L2HGDH family.
What are the subcellular locations of this protein?
Mitochondrion.