PharMolix/UniProtQA huggingface dataset:
Protein: HA2R_MOUSE
Sequence: EDDIEADHVGVYGTTVYQSPGDIGQFTHEFDGDEWFYVDLDKKETVWMLPEFGQLTSFDPQGGLQNIAVVKHNLEILTKRSNFTPAANEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVTDGVYETSFLVNRDHSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRHPGPL
What are the official names of this protein?
H-2 class II histocompatibility antigen, A-R alpha chain.
What is the protein family that this protein belongs to?
Belongs to the MHC class II family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GALT_STRPI
Sequence: MILVDKFVTHVISESSFEEMDRIYLTNRVLARVGEGVLEVETNLDKLIDLKDQLVEEAVRLETIEDSQTAREILGTELMDLVTPCPSQVNRDFWEAYAYSPEQAIEDFYQLSQKNDYIKLKAIAKNIAYRVPSDYGELEITINLSKPEKDPKEIAAAKLVQASNYPQCQLCLENEGYHGRVNHPARTNHRIIRFEMVGQEWGFQYSPYAYFNEHCIFLDGQHRPMAISRQSFERLLAIVEQFPGYFAGSNADLPIVGGSILTHDHYQGGRHVFPMELAPLQKTFRFAGFEQVKAGIIKWPMSVLRLTSDSKEDLINLADKIFQEWRQYSDSSVQILAETDGTPHHTITPIARKRDGQFELDLVLRDNQTSAEHPDGIYHPHKDVQHIKKENIGLIEVMGLAILPPRLKEEVEQVASYLVGEAVTVADYHQEWADQLKSQHPDLTDKEKALAIVKDSVGAIFVRVLEDAGVYKQTEQGQAAFMRFVEQVGISLD
What are the official names of this protein?
Galactose-1-phosphate uridylyltransferase, Gal-1-P uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_MYCGE
Sequence: MHAIVVCGAKQYLVHENESIFVEKLAGKVGQEIQLDKVLMLDEKIGKPYLEKAKVVCVIEKHGLKSKIKLIKHISQKHHLKRYGHRQPYTKLKVVRFIHD
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: GTR2_RAT
Sequence: MSEDKITGTLAFTVFTAVLGSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRRATINYDINGTDTPLIVTPAHTTPDAWEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANSLSLTGALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILISQIAGLSFILGNQDYWHILLGLSAVPALLQCLLLLFCPESPRYLYLNLEEEVRAKKSLKRLRGTEDITKDINEMRKEKEEASTEQKVSVIQLFTDPNYRQPIVVALMLHLAQQFSGINGIFYYSTSIFQTAGISQPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAVFMSLGLVLLDKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFIIALCFQYIADFLGPYVFFLFAGVVLVFTLFTFFKVPETKGKSFDEIAAEFRKKSGSAPPRKATVQMEFLGSSETV
What is the function of this protein?
Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:3048704).  Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:3048704).  May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (By similarity).  Also able to mediate the transport of dehydroascorbate (By similarity).
What are the official names of this protein?
Solute carrier family 2, facilitated glucose transporter member 2, Glucose transporter type 2, liver, GLUT-2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ORP2B_ARATH
Sequence: MPLTRSKSLPATENGGSDRETLQSGRSVAGILYKWTNYGKGWRSRWFLLRDGILSYSKIRRPENVNLLSPSDDLRLIGDISTDRLLRMKSCSGRSRRKHHKNIGIVHLKVSSYRESKSDHRKFYIFTATKTLHLRTDSRSDRAAWLQALASTRGIVPLQSINGDFSFVSPKDLSISTERLKKRLFEEGMNESLVKECEQIVDSEFCEVQEQIKLLHEERKKLLDALRQLEMANLEAEASGIHDDVYQLRNHKYSSLGRGKYSECSTSASSDDKQEFEDISEEDEASFHDTKESFGEPDVGSVLTHFKRRTKLPDPAEKERGVSLWSMIKDNVGKDLTRVCLPVYFNEPISSLQKCFEDLEYSYLLDQAYEYGKSGKSLLRALNVAAFAVSGYASTEGRHCKPFNPLLGETYEADFPEKGIRFFSEKVSHHPTVIACHCEGKGWKFWGDTNLRSKFWGRSIQLEPVGILTLEFDDGEIFQWSKVTTTIYNILLGKLYCDHHGIMKIRGNRQYSCMLKFKEQSILDRNPHQVNGFVEDVTGKKAATVFGKWNDSLYYVAGDGINKASASLLWKATKAPPNVTRYNFTSFAMTLNELIPGLEEKLPPTDSRLRPDQRHLENGEYEKANEEKQRLERRQRMSRQIQESGWRPRWFEPQGESESYKYTGGYWEARDVKSWDDCPNIFGEFTEEVADCA
What is the function of this protein?
May be involved in the transport of sterols.
What are the official names of this protein?
Oxysterol-binding protein-related protein 2B, OSBP-related protein 2B.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: SEPT9_RAT
Sequence: MERDRITALKRSFEVEEIEPPNSTPPRRVQTPLLRATVASSSQKFQDLGVKNSEPAARLVDTLSQRSPKPSLRRVDLAGAKAPEPMSRRTELSIDISSKQVESTASTPGPSRFGLKRAEVLGHKTPEPVPRRTEITIVKPQESGLRRVETPASKAPEGSAMPVTDAAPKRVEIQVPKPAEAPNCPLPPQTLENSEAPMSQLQSRLEPRPPVTEVPYRNQEDSEVAPSCVVDMADNPRDAMLKQAPVSRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPISEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVYFKQRITSDLLSNGIDVYPQKEFDEAEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSNIHFEAYRVKRLNEGNSAMANGIEKEPETQEM
What is the function of this protein?
Filament-forming cytoskeletal GTPase (By similarity).  May play a role in cytokinesis (Potential).
What are the official names of this protein?
Septin-9, Eighth septin, Eseptin, Septin-like protein, SLP.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=In embryonic fibroblasts, associated with actin stress fibers. No apparent co-distribution with microtubules, but some colocalization with vimentin filaments in the perinuclear region.
Protein: PROB_SYNAS
Sequence: MNENREQVLKNVKRVLIKIGSAVLTGDNGLDLERIQHLVDQMAALTHRGYQVVMVTSGAIASGKHRLGITTALKSIPQKQAAAAIGQGRLMRIYSNSFGKHGLYVGQILLTMSDLTDRRRFLNIRNTLSTLMEWGIIAIINENDTVAIDEIKFGDNDNLAAMIANIIEAHLVINLTSTPGLYDRNPASSRNARLIPLVREITEDIEAAASEEGTSVGTGGMKSKVMAAKKVTAFGIPYIIAPGKQKDVLLDIFDGNELGTLFLPMREHLSSRKYWIAFTLRSRGVLSIDAGARTAILEEGKSLLPSGIVGVEGDFIVGDPVTCVDRDGVPLAKGLVNYSAPDIRKIMGLKTSRIEQVLGHKDYDEIIHRDNLAVIRRSRRHREAG
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPRO_MAIZE
Sequence: MPRPLAALLSTACILSFFIALFPRAASSRDILPLGSSLVVESYESSTLQSSDGTFSSGFYEVYTHAFTFSVWYSKTEAAAANNKTIVWSANPDRPVHARRSALTLQKDGNMVLTDYDGAAVWRADGNNFTGVQRARLLDTGNLVIEDSGGNTVWQSFDSPTDTFLPTQLITAATRLVPTTQSRSPGNYIFRFSDLSVLSLIYHVPQVSDIYWPDPDQNLYQDGRNQYNSTRLGMLTDSGVLASSDFADGQALVASDVGPGVKRRLTLDPDGNLRLYSMNDSDGSWSVSMVAMTQPCNIHGLCGPNGICHYSPTPTCSCPPGYATRNPGNWTEGCMAIVNTTCDRYDKRSMRFVRLPNTDFWGSDQQHLLSVSLRTCRDICISDCTCKGFQYQEGTGSCYPKAYLFSGRTYPTSDVRTIYLKLPTGVSVSNALIPRSDVFDSVPRRLDCDRMNKSIREPFPDVHKTGGGESKWFYFYGFIAAFFVVEVSFISFAWFFVLKRELRPSELWASEKGYKAMTSNFRRYSYRELVKATRKFKVELGRGESGTVYKGVLEDDRHVAVKKLENVRQGKEVFQAELSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILFSEGGNILLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLNRGGSTQNVSHVRGTLGYIAPEWVSSLPITAKVDVYSYGVVLLELLTGTRVSELVGGTDEVHSMLRKLVRMLSAKLEGEEQSWIDGYLDSKLNRPVNYVQARTLIKLAVSCLEEDRSKRPTMEHAVQTLLSADD
What is the function of this protein?
Probable receptor.  Interaction with a ligand in the extracellular domain triggers the protein kinase activity of the cytoplasmic domain.
What are the official names of this protein?
Putative receptor protein kinase ZmPK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: VPX_HV2KR
Sequence: MADPRKTVPPGNGGEVTIGEAFAWLERMVEAINREAVNHLPRELIFQVWQRSWRYWHDDLGMSQSYTKYRYLRLMQYAMFIHVKKGCTCLGGGHGPGGWRPGPPPPPPGLV
What is the function of this protein?
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells.  Targets specific host proteins for degradation by the 26S proteasome.  Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1.  This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1.  In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
What are the official names of this protein?
Protein Vpx, Viral protein X, X ORF protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus VPX protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.
Protein: KPK2_ARATH
Sequence: MVSSQCSVANKNQTGKPFQKHLSLSISPPKSVLGDNLELQFSDVFGPMPEANSEEACDVAYDEPAVVYSRSHSLVGPSLVVSHSLKMNKLTLRETEDSVDLVECVEGESIKENDEFSGNDDTDSEKSPEEVSGVVGIEDFEVLKVVGQGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNHAEYMKAERDILTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDVDGHVMLTDFGLAKEFEENTRSNSMCGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPFLGSKGKIQQKIVKDKIKLPQFLSNEAHALLKGLLQKEPERRLGSGPSGAEEIKKHKWFKAINWKKLEAREVQPSFKPAVSGRQCIANFDKCWTDMSVLDSPASSPNSDAKANPFTNFTYVRPPHSFLHRTTSNL
What is the function of this protein?
Downstream effector of TOR signaling pathway.  May be involved in adaptation of plant to cold or high-salt conditions.  Mediates the phosphorylation of MRFs (e. g.  MRF1) (PubMed:29084871).
What are the official names of this protein?
Serine/threonine-protein kinase AtPK2/AtPK19, Ribosomal-protein S6 kinase homolog 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Protein: PSA1_DROME
Sequence: MFRNQYDSDVTVWSPQGRLHQVEYAMEAVKLGTATVGLKNKDYAVLVALCKPTSELSDTQRKIIPIDDHLGISIAGLTADARVLSRYLRSECLNYKHSYDTTYPVSRLITNLGNKMQTTTQRYDRRPYGVGLLVAGYDERGPHIYQVTPSATFFNCKANSIGSRSQSARTYLEKNLNKFLDSSKDEIIRHGIRAILGTLPTDEQGKDAGQYDITVAIVGKDQPFTILSNKDSAKHVAIAKENDNDTPRNDDDDDRPSPPEEPAAGPRDPEVLVATEQRP
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit alpha type-1, PROS-Dm35, Proteasome 35 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ZIPA_SHEAM
Sequence: MEDLQLVLFVLGAIAIVAVLVHGFWSIRKQQPRTIKEQPRTPYAMSPGRRDAEGFDADGIGEVRVRKLAPDDKKSEPVKASHDDTFSLSDEPKVRRVKERQEPVLESRADAAPNHAAHERRGHDFRHHEEPSPSARQVQLGLLDDLDQEPSQGELYEEINASVADYDDDYDAYENQPASVDRAEAARVPADQGQAAHSAATQAEPQAKAEEPLPDPRDVLVLHVVAREGQVLAGAELLPCLLELNFKYGDMEIFHRHEDNAGNGKVLFSLANMLKPGTFDPDTMEQFNTHGIVLFMTLPCHGEAVMNFSLMLNSACQLADDLDALVLDGQRQLWSDATKAQYLARIRANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: RL7_STRR6
Sequence: MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAADAADAGAAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPALVKEGVATAEAEEIKAKLEEAGASVTLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: AMPP3_METAQ
Sequence: MNYHSFLPLRRSSLSHSTTPPSKSRNQTRYIWSIALQNTMAVEDFEAVLKAKYPGKAHAKRVVDLIRKTKPDANGVIYLEGRMTKLLEDNDSPEPFRQRRFFYYLTGCNLADCALAYDIQSSKSILFIPPIDPDDVIWSGLPLSIDEALSRYDVDEVKFTTEVNPTLTHLAKQSPNSTVFAIANQVSDNVTFIEFGSKDFETVKKAIEVSRVVKDEFEVAMIRKANHISSLAHKAVIERSKTAATEQELYATFLERCVSHAAPEMAYHPILAAGKAAATLHYVDNNAPLKGKQNLLIDAGCEWNNYASDITRTFPLTGKFTKESRDIYDIVLRMQKECTELIKGGMIWDDLHLHAHKVAIDGLLALGILKGDAKEILDARTSAAFFPHGLGHHLGMDTHDTGGNPNPNDPDKLFRYLRLRGHVPAGAVVTVEPGIYFCDFIIKPYLDDHVHSKYIDAAVLNKYWDVGGVRIEDNIHVTENGYVNLTTAIKEVSDVEAVSAK
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase pepP, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: IOLC_LISMC
Sequence: MNLNKHSERKFDLITVGRACIDLNAVEYNRPMEETMTFSKYVGGSPANIAIGTAKLGLKVGFIGKISADQHGRFIEKYMRDLSINTDGMVKDTEGRKVGLAFTEIKSPDECSILMYRENVADLYLTPEEISEDYIKEARVLLISGTALAQSPSREAVLKAVSLARKNDVAVAFELDYRPYTWTNTEETAVYYSLVAEQADVIIGTRDEFDMMENQVGGKNEATKAHLFQHQAEIVVIKHGVEGSFAYTKAGETFQAKAYKTKVLKTFGAGDSYASAFLYGLFSGESIETALKYGSAAASIVVSKHSSSDAMPTADEIKALIAQAE
What is the function of this protein?
Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).
What are the official names of this protein?
5-dehydro-2-deoxygluconokinase, 2-deoxy-5-keto-D-gluconate kinase, DKG kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: AS1C_DOLGE
Sequence: MARLLVVSVGVFLAVIMLSSETMSLPAGENLPALTLFEAQNQLIGLSQEQRQCKKIGEHCYVADECCSKRCLFYAAKCVS
What is the function of this protein?
Neurotoxin that may modulate ions channels (other than those tested) (PubMed:31870846).  In vivo, induces neurotoxic effects when injected into insects (tested on L. cuprina and A. domesticus) (PubMed:31870846).
What are the official names of this protein?
U-Asilidin(1)-Dg12.
What is the protein family that this protein belongs to?
Belongs to the asilidin-1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PGLR2_PENOL
Sequence: MIAGSKLLMLGLFGALAVHALPEPAKAQVTAAPKLEERATSCTFSGSAGASSASKSKTACATIVLSAVAVPSGTTLDLTGLNDGTTVIFEGETTFGYKEWSGPLVSVSGTDITVKGASGATLNGDGSRWWDGKGSNGGKTKPKFFYAHKMFSSTISDIHIVNSPVQVFSINGATDLTLSGITVDNRDGDTDEGGHNTDAFDVGSSTGITITGATVYNQDDCLAVNSGTDITFTGGLCSGGHGLSIGSVGGRSNNDVANVIIENSQIQDSTNGVRIKTVYEATGSVKNVTYKDITLSGITKYGIVIEQDYENGSPTGTPTDGVPITDLTLDGVKGTVASSGTNVYILCAEGACSDWTWDGVSVSGGKTSSACENVPSSASC
What are the official names of this protein?
Polygalacturonase 2, PG 2, Pectinase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: APOC2_ATEGE
Sequence: DMYSKSTAAMSTYAGILTDQVLSMLKGEE
What is the function of this protein?
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma.  Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
What are the official names of this protein?
Apolipoprotein C-II, Apo-CII, ApoC-II, Apolipoprotein C2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: STHA_ECOLI
Sequence: MPHSYDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYQNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNARFVDEHTLALDCPDGSVETLTAEKFVIACGSRPYHPTDVDFTHPRIYDSDSILSMHHEPRHVLIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALQNIGLETDSRGQLKVNSMYQTAQPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MACB1_PARDP
Sequence: MAETGAPLIRLRGVGREYPSGEGVLRVLTDIDLDIGQGEFVAVMGASGSGKSTLMNILGCLDRPSSGSYRMDGREVARLGAGELAALRRETFGFIFQRYHLLSEMTALGNVEVPAIYRGLPADARRARARDLLERLGLGDRTGHRPGQLSGGQQQRVSIARALVNDARVILADEPTGALDSRSGDEVLGILERLNAEGRTVVIVTHDPRVAARAHRVVEIADGRIVADRRTGAPAADPGPGPAQAPQPAPQPAPVQAPVQARVQARAAVPVLGRLAEALRMALLSMRAHKLRSFLTMLGIIIGIASVVSVVALGEGSRRQVLQNIAGLGTNTLQIFPGRDFGDMRSGRVTTLVTADAAALARQPHVASVSPTVGTSATLRHGATEASAQISGVGEQYFDVAGVALTQGRGFDEADVAAMGQNVVIDENTRTSLFGDGPALGQVFMAGKVPLRVIGVAEAQNRGPGGSTSLTVYAPYTTVQARYLGSTSVSGLTLRVADDVDMALAEQMVADILTRRHGTRDFFIVNNDQIRQTITSTTQTLALLIAAIAVISLVVGGIGVMNIMLVSVTERIGEIGLRMAVGARRGDIRAQFLIEAVLVCVIGGIAGILAALGFGLAFERMSSDFTLVYSPLSMLAALASACAIGLAFGYLPAVNAAKLDPVKALQKG
What is the function of this protein?
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB 1/2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPA_TRIV2
Sequence: MTAISDRFETLKQNQECALIPFITAGDPDLETTAAALKILDSNGADIIELGIPYSDPLADGPVIQAAATRALQNGTKLESVLEMLKVTTPSLQAPIVLFTYYNSILHRGIDNFLEQVAAAGVAGLVVPDLPLEEAAGLLKPATERGIDLILLIAPTSSSERIEAIARSSQGFIYLVSVTGVTGMRSQVEGRVLDLLQKVRQVTDKPLGVGFGISQPAQATQVRDWGADAAIVGSAFVQRLATGTPAEGLSAIAEFCQSLKAAIKTS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: KIPN_BPT4
Sequence: MKKIILTIGCPGSGKSTWAREFIAKNPGFYNINRDDYRQSIMAHEERDEYKYTKKKEGIVTGMQFDTAKSILYGGDSVKGVIISDTNLNPERRLAWETFAKEYGWKVEHKVFDVPWTELVKRNSKRGTKAVPIDVLRSMYKSMREYLGLPVYNGTPGKPKAVIFDVDGTLAKMNGRGPYDLEKCDTDVINPMVVELSKMYALMGYQIVVVSGRESGTKEDPTKYYRMTRKWVEDIAGVPLVMQCQREQGDTRKDDVVKEEIFWKHIAPHFDVKLAIDDRTQVVEMWRRIGVECWQVASGDF
What is the function of this protein?
Acts as a 5'-hydroxyl kinase, a 3'-phosphatase and a 2',3'-cyclic phosphodiesterase.  Catalyzes the transfer of the terminal phosphate of ATP to the 5'-hydroxyl termini of ribo- and deoxyribonucleotides.  In the presence of ADP the enzyme also catalyzes an exchange reaction.  In the exchange reaction, an excess ADP causes the enzyme to transfer the 5' terminal phosphate from phosphorylated DNA to ADP (PubMed:5323016, PubMed:199248).  Involved in countering a host defense mechanism which activates T4-induced anticodon nuclease and shuts off viral translation.  The polynucleotide kinase modifies the ends of nicked tRNA generated by the antiviral response of the host bacteria and facilitates repair by T4 RNA ligase (PubMed:2444436).
What are the official names of this protein?
Polynucleotide kinase, PNK, Deoxynucleotide 3'-phosphatase, Polynucleotide 5'-hydroxyl-kinase.
Protein: PROQ_VIBVU
Sequence: MTEKLKNSKEVIAYIAECFPKCFTLEGEAKPLKIGIFQDLAERLSEDEKVSKTQLRAALRQYTSSWRYLHGVKLGATRVDLDGNECGVLEEEHVEHAKATLAESKAKVQARRKEQAQKARDEEKSKPKTKKAPQQRRANKPQAQKPAKQPVETRALNADELITGKAVNVNMGKGNMAATIVEINKDDVRVQLSNGLQMVVKAEHLRA
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMDH_STAES
Sequence: MWENKFAKESLTFDDVLLIPAASDVLPSDVDLSVKLSDKIKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNQEDRKLIGILTNRDLRFIEDFSIKISDVMTKDNLITAPVGTTLDEAEAILQKHKIEKLPLVENGRLEGLITIKDIEKVLEFPYAAKDEHGRLLAAAAIGTSKDTEIRAQKLVEAGVDALIIDTAHGHSKGVINQVKHIKETYPEITVVAGNVATAEATRALFEAGADVVKVGIGPGSICTTRVVAGVGVPQITAVYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEVFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKTPRKFVPEGIEGRTAYKGPLQDTIYQLMGGVRAGMGYTGSENLKKLREEAQFTRMGPAGLAESHPHNVQITKESPNYSF
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: STMN4_MOUSE
Sequence: MTLAAYKEKMKELPLVSLFCSCFLSDPLNKSSYKYEADTVDLNWCVISDMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELKEEASR
What is the function of this protein?
Exhibits microtubule-destabilizing activity.
What are the official names of this protein?
Stathmin-4, Stathmin-like protein B3, RB3.
What is the protein family that this protein belongs to?
Belongs to the stathmin family.
What are the subcellular locations of this protein?
Golgi apparatus. Cell projection, growth cone. Cell projection, axon.
Protein: ASSY_GEOSL
Sequence: MAKAHKDVKKIVLAYSGGLDTSIILKWLKNEYGCEVIAFSADLGQGDELAPIRDKAIATGADKVYIDDLKEEFVKDFVFPMFRANAIYEGHYLLGTSIARPLIAKRQMEIAKIEGADAVSHGATGKGNDQVRFELAYYHFDPAITVVAPWREWKLNSRQALVNYARKNGIPIPVTKKRPWSSDRNLLHISFEGGILEDTWAEPPENMYVLTKAPEKAPNKPQFVEIEFKNGNAVAVDGEKMSPAQLLAHLNYIGGEHGIGRVDLLENRSVGMKSRGVYETPGGTILREAHSAVEQITMDREVMRIRDSLIPEYARQVYAGYWFSPEREMLQTLIDDSQKCVNGVARVKLYKGHCRTVGRKSETNSLFNLDFATFEKDQVFNQADATGFIKINSLRLRIRSLMQGKK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD_CHLPB
Sequence: MQELGKAEHTSIRVTPQGENRVIVEKDLSSEEMILNMGPQHPSTHGVLRLECKTDGEVVIEAEPYLGYLHRCFEKHAEMVDYPGIVPFVDRMDYLASMNNDFAYCIAVEKLLDIEIPRRVEFMRVIVSEINRIASHLVAIGTYAIDLGAFTPFLFCFRDREHMLNLLEWTSGARMLYNYILIGGVAYDFPKDFARRTLEFVKYFRPKALELQKLLTENEIFVKRTKGVGMMPADVAINYGWSGPMLRGSGVEWDLRRVDGYSVYPELDFKVCVPDGKFSDIGDSLSRHVVRALEIEESLNIIEQCLDKMPEEEGFDPRSAIPKRIRPKAGEVYGRAENPRGELGFYIISDGKSTKPLRCKARSSCFVNLSAMKELSLGQLIPDLVAIIGSIDIVLGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.