PharMolix/UniProtQA huggingface dataset:
Protein: SYT_PSEPF
Sequence: MPTITLPDGSQRSFDHPVSVAEVAASIGAGLAKATVAGKVNGKLVDACDIIDSDATLQIITPKDEEGLEIIRHSCAHLVGHAVKQLYPTAKMVIGPVIDEGFYYDIAFERPFTPDDMAAIEQRMHQLIDTEYDVIKKVTPRAEVIEVFKARGEDYKLRLVEDMPNEQAMGLYYHEEYVDMCRGPHVPNTRFLKSFKLTKLSGAYWRGDAKNEQLQRVYGTAWADKKQLAAYIQRIEEAEKRDHRKIGKRLGLFHTQEEAPGMVFWHPNGWTLYQVLEQYMRKVQRDNGYLEIKTPQVVDRSLWEKSGHWANYADNMFTTESESRDYAIKPMNCPCHVQVFNQGLKSYRELPMRLAEFGACHRNEPSGALHGIMRVRAFTQDDAHIFCTEEQMQAESAAFIKLTMDVYRDFGFTDVEMKLSTRPEKRVGSDELWDRAEAALAAALDSAGLPYDLQPGEGAFYGPKIEFSLKDCLGRVWQCGTLQLDFNLPVRLGAEYVSEDNSRKHPVMLHRAILGSFERFVGILIEHYEGAFPAWLAPTQAVIMNITDKQADFVVQVEKTLNESGFRAKSDLRNEKIGFKIREHTLLKVPYLLVIGDKEVEMQTVAVRTREGADLGSMPVAQFAEFLAQAVSRRGRPDSE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIM9_KLULA
Sequence: MDQLNGKEQQEFQKIVEQKQMKDFMRLYSNLVERCFSDCVNDFTSAKLTSKEQNCIMRCSEKFLKHSERVGQRFQEQNAAMNQTMGR
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM9.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: ACCD_LIGS1
Sequence: MQLFDELKTISKKHIKANKKAGEKVPSGLWISCPKCQQSIYHKDLGKYKTCPNCYYGFRIHARERLEWLVDTFQEFDTDLETKDPLNFPGYKEKLIKAQQDSKLNDSVLTGIAMIDDVEFALGIMDPYFIMGSMGTVTGEKITRLFERATQKNLPVILFTASGGARMQEGISSLMQMSKISQAVKEHSNAGLLYITVITDPTTGGVTASFAMQGDIILSEPRALLGFAGKRVIEQTIHQKVPDDLQDAETVLKNGFIDNIIKREDQKEKLAWLVKIHSMKGAF
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECFA2_STRSV
Sequence: MGITLKNVSYTYQAGTPFEGPALFGVDLEIKSGSYTALIGHTGSGKSTILQLLNGLLVPNQGSVEVGSTVITADSVNKDIKQVRKKVGLVFQFPESQVFDETVLKDVAFGPQNFGVSKEEAEALAREKLHLVGISEDLFNRSPFELSGGQMRRVAIASILAMEPDILVLDEPTAGLDPSGRKELMRIFEELHRAGMTIVLVTHLMDDVANFADTVYVLDKGRVVKSGQPAQVFQDLDFMESIQLGVPKITKFAHELAEKGMNFSHYPITIEEFKEILHG
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ENO_THIDA
Sequence: MSAIIDVIAREILDSRGNPTVEADVLLESGVIGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHVNTEICEAIIGLDVEDQAFIDQTMIELDGTENKSRLGANALLAVSMACARAAAEQAGLPLYRYLGGAAPMQLPVPMMNIINGGAHANNNIDMQEFMVIPVGAPSFREALRYGAEVFHALKKLLDDAGMTTTVGDEGGFAPNLESHEAALKLIVQAIEKAGLQPGIDVAIGVDCASSEFYKDGLYHIDSENLKLTSAAFTDYLAAWCDKYPIISIEDGMAEGDWDGWKILTDRLGRRVQLVGDDLFVTNAKILKEGIEKDIANSILIKVNQIGTLSETFQAIEMAKQAGYTSVISHRSGETEDTTIADLAVATNARQIKTGSLSRSDRMAKYNQLLRIEEELGDTASYPGRDAFRQRG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RK29_ARATH
Sequence: MLSLSIATPGTAAIFRRGTASATSTSSSFHGVRIQHQVSARVPAAATISSSSPKPSVVMMSKREAELKEIRSKTTEQLQEEVVDLKGELFMLRLQKSARNEFKSSDFRRMKKQVARMLTVKREREIKEGIKKRLSRKLDRQWKKSIVPRPPPSLKKLQEEEAAEEAAEAAKSA
What are the official names of this protein?
50S ribosomal protein L29, chloroplastic, CL29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ESRP2_RAT
Sequence: MTPPPPPPPPPGPDPAVDSSTDPCPEPQSLVVLFGATAGALGPDLGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSPQCREASGLSADSLARAESLDKVLQQFSQLVSGDVALLGGGPYVLCTDGQQLLRQVLHPEASRKNLVLPDTFFSFYDLRREFHVQHPSTCSARDLTVGTMAQDLGLETDATEDDFGVWEVKTMVAVILHLLEGPNGHLFSKPEVVKQKYETGPCKADVVDNETVVRARGLPWQSSDQDVARFFKGLNIARGGVALCLNAQGRRNGEALIRFEDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGTSLEVARFLSREDQVILRLRGLPFSAGPADVLDFLGPECPVTGGVDGLLFVRHPDGRPTGDAFALFACEELAQAALRRHKGMLGKRYIELFRSTAAEVQQVLNRYAASPLLPTLTAPLLPIPFPLAGGTGRDCVRLRGLPYTATIEDILSFLGEAAADIRPHGVHMVLNQQGRPSGDAFIQMMSVERALAAAQRCHKKVMKERYVEVVPCSTEEMSRVLMGGSLSRSGLSPPPCKLPCLSPPTYATFQASPALIPTETTALYPSSALLPAARVPAAATPLAYYPGPATQLYMNYTAYYPSPPVSPTTVGYLTTPPTALASTPTSMLSQPGALVRMQGVPYTAGMKDLLSVFQAYQLAPDDYATLVPVGDPPRTVLQAPKEWVCL
What is the function of this protein?
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms.  Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2.  Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT).  Acts by directly binding specific sequences in mRNAs.  Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity).
What are the official names of this protein?
Epithelial splicing regulatory protein 2, RNA-binding motif protein 35B, RNA-binding protein 35B.
What is the protein family that this protein belongs to?
Belongs to the ESRP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1474_TOLAT
Sequence: MERFIERLMYSARWIMAPIYLGLSLALLALGIKFFQEVFHIFTVIISMKEVELILIILSLIDISLVGGLIVMVMYSGYENFVSRLDLDDHDDKLSWLGKLDAGSLKNKVAASIVAISSIHLLKVFMNTENIADDKIKWYLLIHITFVMSAFAMGYLDKLLRDKDSPH
What are the official names of this protein?
UPF0114 protein Tola_1474.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VGP_EBOSM
Sequence: MEGLSLLQLPRDKFRKSSFFVWVIILFQKAFSMPLGVVTNSTLEVTEIDQLVCKDHLASTDQLKSVGLNLEGSGVSTDIPSATKRWGFRSGVPPQVVSYEAGEWAENCYNLEIKKPDGSECLPPPPDGVRGFPRCRYVHKAQGTGPCPGDYAFHKDGAFFLYDRLASTVIYRGVNFAEGVIAFLILAKPKETFLQSPPIREAANYTENTSSYYATSYLEYEIENFGAQHSTTLFKINNNTFVLLDRPHTPQFLFQLNDTIQLHQQLSNTTGKLIWTLDANINADIGEWAFWENKKNLSEQLRGEELSFETLSLNETEDDDATSSRTTKGRISDRATRKYSDLVPKDSPGMVSLHVPEGETTLPSQNSTEGRRVDVNTQETITETTATIIGTNGNNMQISTIGTGLSSSQILSSSPTMAPSPETQTSTTYTPKLPVMTTEEPTTPPRNSPGSTTEAPTLTTPENITTAVKTVWAQESTSNGLITSTVTGILGSLGLRKRSRRQVNTRATGKCNPNLHYWTAQEQHNAAGIAWIPYFGPGAEGIYTEGLMHNQNALVCGLRQLANETTQALQLFLRATTELRTYTILNRKAIDFLLRRWGGTCRILGPDCCIEPHDWTKNITDKINQIIHDFIDNPLPNQDNDDNWWTGWRQWIPAGIGITGIIIAIIALLCVCKLLC
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in GP2, releasing the fusion hydrophobic peptide.
What are the official names of this protein?
Envelope glycoprotein, GP1,2, GP.
What is the protein family that this protein belongs to?
Belongs to the filoviruses glycoprotein family.
What are the subcellular locations of this protein?
[GP2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In the cell, localizes to the plasma membrane lipid rafts, which probably represent the assembly and budding site. SUBCELLULAR LOCATION: [GP1]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=GP1 is not anchored to the viral envelope, but forms a disulfid-linked complex with the extravirion surface GP2. In the cell, both GP1 and GP2 localize to the plasma membrane lipid rafts, which probably represent the assembly and budding site. GP1 can also be shed after proteolytic processing. SUBCELLULAR LOCATION: [Shed GP]: Secreted. Note=GP2-delta bound to GP1 (GP1,2- delta) is produced by proteolytic cleavage of GP1,2 by host ADAM17 and shed by the virus.
Protein: ECFT_MACCJ
Sequence: MLDKMILGRFVPLQSFVHRLDPRMKMVFVFIMMILIFLMNNWQTYAVGIILIFIILKASNLSFMFLFNGLKPILFLLIFTLLMHIFLTKGGATLVDYGIINIQSQGVIMGIMISLRFILIIFLTTIMTLTTNPIELTDAIESLLKPFKKLKLPVHELALMMSIALRFIPTLMDETQKVMKAQMSRGSDMTAGTLKERIKAVIPLLVPLFVSAFKRAEDLAIAMEVRGYKGDAGRTKYRKLDWHTYDTLSLLTLIPITLLILYLKN
What is the function of this protein?
Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter transmembrane protein EcfT, ECF transporter T component EcfT.
What is the protein family that this protein belongs to?
Belongs to the energy-coupling factor EcfT family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GAB2_MOUSE
Sequence: MSGGGGDDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNEHSKKPLRIINLNLCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEADMNKWVQSICQICGFNQAEESTDSLRNLSSASHGPRSSPAEFSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSSHMQPTLSTSAPQEYLYLHQCISRRTENARSASFSQGTRQKSDTAVQKLAQSNGHCINGVGGQVHGFYSLPKPSRHNTEFKDSTYDLPRSLASHGHTKSSLTGSETDNEDVYTFKMPSNTLCRELGDLLVDNMDVPTTPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETSQWGSIQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPARGSGESASWSAEPPGKTAVGRSNSASSDDNYVPMNPGSSTLLAMERPGDNSQSVYIPMSPGPHHFDPLGYPSTALPIHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPVTKSWSRINHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPGSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL
What is the function of this protein?
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways.  Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling.  In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation.  Also involved in the regulation of cell proliferation and hematopoiesis.
What are the official names of this protein?
GRB2-associated-binding protein 2, GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2, PH domain-containing adaptor molecule p97.
What is the protein family that this protein belongs to?
Belongs to the GAB family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.
Protein: UPPP_BUCAT
Sequence: MLDLHQIIVSIIIGVIEGITEFLPISSTGHMIIASHWLKIDNENTKILEIFIEFGSALSILYFFHKKILRILKFNINVKKTNTKNLHIILAILPTIFFGLLFYKKIKLLFNTYNVMYALILGGIFLLISEIFKPKKYKTCSINDISLLQSAIIGFFQIFCLYPGFSRSGATIGTAILLGIKRSVAIEFSFIISIPLIMGASFYDFINNMHNFKILDLPIFFIGFMISFIVSILCIKKLLKIINRTSLIFFGIYRFIISGLIYFIN
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCH32_HALSA
Sequence: MAAVQIDDYGPWTTEPAPRRETDLQALQARLFADVADFLGGRDGYAFAGRFDNMVGAATGIAPAAFERLQERIRNRYPVTVSVGIGTARTPADALDAAGTALRDAGSAQDENRQEALSHRSPPGFAGTPGAVTIAHFDVVDATGTYTDTVSPVRAGTEIQGAVTTLAEYLYDTHDAVTQFVGGDNAIAVCPEIDAGIVDDATAHVREAAGVDFQVGVGHGDTPHDAGADAKHALETCRATGARVHGPWTTADD
What is the function of this protein?
Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP.  Also has an independent pyrophosphate phosphohydrolase activity (By similarity).
What are the official names of this protein?
GTP cyclohydrolase III 2.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type GTP cyclohydrolase family.
Protein: XPT_STRS7
Sequence: MRLLEERILAEGTVLGETILKVDQFLTHQVDYRLMKEIGRVFADQYADLGITKVVTIEASGIAPAVYTAEALEVPMIFAKKHKNITMTEGILTAEVYSFTKQVTSTVSIAGGLLSKEDRVLIIDDFLANGQAAKGLIDIIQQAGAKAVGIGIVIEKSFQAGRQLLEDLGVEVTSLARIKHFDNGTVSFLEADA
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAL_POLSJ
Sequence: MNQLESLKQFTTVVADTGDFRQLGQFKPQDATTNPSLILKAVQKADYQPLLKETVARFKGRALDEVMDRLLVRFGCEILSIIPGRVSTEVDARLSFDANASYTRGERIVELYQAEGIHIDRVLIKVAATWEGIQAAERLERRGIHTNLTLLFSFCQAVACGQARVQLISPFVGRIYDWYKKSAGAAWDEAANAGANDPGVKSVRQIYNHYKHFGIATEVMGASFRNAGQITALAGCDLLTISPELLAQLAASEAPLARSLDAGAARSLDLPAVNYDETGFRYALNEDAMATEKLAEGIRAFAADAIKLEQLMVAA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_VIBVU
Sequence: MSMQDPISDMLTRIRNGQAANKVAVKMPSSKLKVAIAALLKAEGYIVDFAVEGEAKPELEVTLKYFQAKPVIEQLKRVSRPGLRVYKKKDDLPSVMGGLGVAVVSTSKGLMSDRAARKAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RLMH_CARHZ
Sequence: MEITIVAVGKIKERYLKEGIAEYLKRLSPYARLAVIEVDDENAPENLSPAEAEKVVKKEGERILAKITPSSFVIALDLKGKNLSSEEFAHFISEKNLYGQSKLTFIIGGSLGLSREVLERADFKLSFGRMTYPHQLMRLILLEQIYRAFKIIRGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_METMP
Sequence: MSSPDFKLKAEFKPKGSQLEAIAGLVKDLEKNPEKSKQTLLGVTGSGKTFTIANVIEKVQKPTLVIAHNKTLAAQLYNEFKEFFPENRVEYFVSYYDYYQPESYIPQKDQYIEKDAQINPKIEQMRLRATSAILSRRDVIIVASVSCIYGLGNPELFKEMGFELKVGEKIKRSDIIEKLVDIQYERNDMELVPGRFRVKGDTLDIIPGYQDDILRVEMFGDEIDRIYELDPKNMSKKHEIDSFYMYPAKHFVIPEEDKKNAINSILKELDEWLPNLDMLKSHRLKQKTLYDIEMIEETGSCKGIENYSRHFENRKEGEPAYCLLDYFPEDFLIVIDESHQTIPQIRGMYKGDRSRKQSLIDYGFRLPSAYDNRPLKFEEFKKYMNNVIFVSATPGEYELDNSNQVVEQIIRPTGLLDPEVEIRPIENQVEDIIKETEKMVEKGERVLITTLTKRLAEELTEYLAKRNVKARYLHSDIDTIERTEIIRNLRLGKFDCLVGINLLREGLDIPEVGFVGILDADKEGFLRNDKSLIQTIGRAARNANSKVVLYAGKMTDSIKKAVSETERRRKLQKEHNEKHNITPQTIVKPIREKVVDISDVKHIPVADIPNVIVELEAEMYEAAEALEFEKAIKIRDTIAKLKKKIK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAG_NITEC
Sequence: MKNDQKYDIKVQVRTTYLQDQSDPAQEQYVFAYTITINNIGSVASQLVSRHWIITGGDGETREVRGLGVVGEQPLLKPGESFEYTSGTAISSIAGSMKGSYQMVAEDGFHFSVEIPEFILSVPRVLH
What are the official names of this protein?
Protein ApaG.
Protein: VPS53_PONAB
Sequence: MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRTELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDEPTPEMEELATEKGDLDQPKKPKAPDNPFHGIVSKCFEPHLYVYIESQDKNLGELIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPKTTTSSGGLTISSLLKEKEGSEVAKFTLEELCLICSILSTAEYCLATTQQLEEKLKEKVDVSLIERINLTGEMDTFSTVISSSIQLLVQDLDAACDPALTAMSKMQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCIKFANSFIPKFITHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPSIGSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNTETFQKILDMKGLKRSEQSSMLELLRQRLPAPPSGAESSGSLSLMAPTPEQESSRIRKLEKLIKKRL
What is the function of this protein?
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).  The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.  Acts as component of the EARP complex that is involved in endocytic recycling.  The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 53 homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS53 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
Protein: DXS_AZOC5
Sequence: MTVTKTPLLDTVRDASDVRRLPEEKLSQLADELRAETISAVSVTGGHLGAGLGVVELTVALHHVFNTPHDRLIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTRRSESEYDPFGAAHSSTSISAGLGMAVARDLSGGDRNVIAVIGDGAMSAGMAYEAMNNAGAMDSRLIVILNDNDMSIAPPTGAMSAYLARLISGRTYLSLREIGKQLAGHLPKFVKDGAAKAEEFARGFWTGGTLFEEMGFYYVGPIDGHNLEHLLPVLKNVRDAKTGPILVHVVTQKGKGYPPAEASADKYHGVVKFDVVTGAQVKAKSNAPSYTRVFAETLIDEARRDDKVVAITAAMPSGTGLDLFGQAFPQRTFDVGIAEQHAVTFAAGLAAEGYRPFCALYSTFLQRGYDQVVHDVALQGLPVRFAIDRAGLVGADGATHAGAFDLAMLTCLPGFTVMAPADEAELTHMIATAVGHDAGPIAFRFPRGEGVGVERPEKGERLPIGKGRVVREGQDIAFLSLGTRLAACLDVAERLSSLGISATVADARFAKPIDRELIAHLARTHAALVVVEEGSVGGFGSQVLQFLSDEGLMDGGLKVRALTLPDTYIDHDTPAAQLAEAGLDADGIYKRALALVQPAERRGAVATKRA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: HIS4_SALTO
Sequence: MSLTLLPAVDVADGQAVRLVQGAAGSETVYGDPFDAALAWQRDGAEWIHLVDLDAAFGRGSNAELLADVVRRLDVRVELSGGIRDDASLQAALATGAARVNIGTAALEDPQWCDRVCGEYGDRVAIGLDVRGQTLSARGWTRDGGDLWEVLARLDRAGASRYVVTDITKDGTMRGPNLGLLREVCARTNAPVIASGGISTLADLRALAALEPVGVEGVIAGKALYAGAFTVAEALRTLADA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.