PharMolix/UniProtQA huggingface dataset:
Protein: RSMH_CUTAK
Sequence: MLMATDAIGSDAVHIPVMRARILDLLAVVLKSGRRVHVDGTLGMGGHAEAVLRRFPDVELVGIDRDQQALTMAEARLEPFADRVHLVHAVHDELPEVLDDLGLDYVDSVLLDLGLSSFQIDEVERGFSYSVDSPLDMRMDQSSGRTAAQILNESDPGALVRMLREYGEEKFADRIVRAIVTERDRQPIETSGRLVEIITEAIPATVRRKRHSHPAKRTFQALRIAVNREMETLPAVLPRALDRLDVGGRIAVLSYHSLEDRPVKEAFRDACADTAPAGLPMVPESMAAKFNPVTRGAERPDADEVATNPRSASARLRVIERVRPGPVNRQHATKESR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_CHLSY
Sequence: MLERVAVLYNPLSDASIKLSRELADWLVERGVKTTRGVSQEFRDQPHLVADCDLMIALGGDGTVLRAARLCFPHNIPVLPVALGHLSFMAEIGPDEVYSGCEQIMNGGGWFDERSLVRAQLWRGGQKLSQHTALNEVVISRSDLSRIVNVHVTIDDSPLTTYHADGVIVATATGSTAYALAAGGPIVDPRSQALVLVPIAAHLTNIPSMVLHEDAVVTMQLRSRHHALLAVDGRENIDLIEGDEVVVRRSPQVCTFVRLRPSNQFYTQLVARLRRS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_ELHVK
Sequence: MMDSRATYVPPKKISESNSNAEEDPTDCSKPITLKVPTVSETVLATIPHKPQRHLTVYLEGCVGVGKTTMFKYVVDNMFVHTAYDEPMDHWTKWFPENILQTIHEAVNLPTQEQHAYVFSCQNLIATSFLARESGIVKTHPAPFDPSVDVISIADRHALAAYVAFPIHHFLQGRFTYMELQCMLWAFKQDSVDTIFLLQGCSEETLRRVKRRNRKVEHGVTIEYINSLQAAYTVILSTWYRATEYQYSAKRTVSEEISFFIAGPRRTLFYILYDKRPITLPEIEILKLFRKISNDLKKLVLIPVNFQRLVYSSALRRLQDLLIVTPGVTSYIHNENVDTATCAVADNPHFNHHDVS
What is the function of this protein?
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis.  The dTMP serves as a substrate for DNA polymerase during viral DNA replication.  Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae thymidine kinase family.
Protein: RL5_XANOP
Sequence: MNTRLEKFYKENVVPALMKEFGYTNPMEVPKLVKVTLNMGVGEAASNKKILENAVADMSKISGQKPVVTKSRVSVASFKIRDGWPIGCKTTLRRAKMYEFLDRLINISLPRVRDFRGVSGRSFDGRGNFNMGVKEQIIFPEIDFDAVDAIRGMDIAVTTTAKTDAEAKALLAAFKFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ATPA_LEPBJ
Sequence: MKIKTDEITSVLKQEILNYKKDLGVDEVGTVLEIGDGIARVYGLKNVMSGEMVEFQNGIFGQAFNLEDNSVGVVVYGDYLAIQEGFTVKRTSRILEVPVGPELLGRVVNPLGEPLDGKGPINAKLTRPVESPAPGIAMRQPVGEPMQTGIKAIDAMIPIGRGQRELIIGDRGTGKTSIALDTIINQKGTGVICVYVAIGQKASTVASTVEMLRNKGALEYTIVVSATAAEPAPLQYIAPYSGCSMAEYFMYNEKKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLDDKYGAGSLTALPIIETQEGEVSAYIPTNVISITDGQIYLQSNLFASGNRPAVDVGISVSRVGSAAQIKAMKQVAGKMKLELAQFRDLEAFAQLGTELDPATQAQLDRGNRIVQMLKQPVSSPFPVEEQVVEIFAVTRGFMDKIPVPKVQQYGKFLLTRIKEQHSEVLEAIRKEKKISDEEKLGEVLSAIAEEFLRKH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KDPB_HALSA
Sequence: MAEITVTIDTDQQKQAISDSFAKLDPQYLVKNPVLFVVELGTIIGLVMTIAPGLFGATGSRVYYAVITVLLGFTVIFANYAEAYAELEGEAQADSLRALQTEAEGKLLQNDDVDIEDISEDDYEVVASTEIEQDAVVFVDEGDIIPRDGTVVEGSASVDESAITGESEPVIRQSGGDRTSVVGGTEVLSDRIKVEVTSEEGESFLDQMIGLVEDAQRQKTPNEIAMTILLSGLTLVFVVAVATMFFFGEYLASFVGGFAGLDVAELVALLVALMPTTIGALLAAIRVAGMTRVTRRNVIAKSGRAVEAAGDLDALILDKTGTITTGERVAQDFHPLGDADDADVVRASYQSSLYDETTEGRSIVKLAEKMNGKVQTDGGQSASEELDEPGDSVDAPRDVSVTLDAEGLSESNFVPFSAETRMSGIDLSDGTEIRKGAVDAVEEYATTVPGKLRQKSNAISESGGTPLAIAVDGQVVGIIELQDELKPGIADRIAEIQKMGVETIMATGDNQRTARWVADQVGIDEFHAEFDPEEKIELVEDIQDDGKLVGMTGDGTNDAPALAKADVGLAMNAGTNAAKEAGNMVDLDSNPSKIIEVVGIGKQLLMTRGSLTTFSVANDVAKYFVLLPAILAAAIPGLGAMDILNLSTPASAVTATLMYNAFIIPLLIPLALRGVDYKAQSGAQLLRKNLIVYGGGGLIAPFIFIKAIDMLFVALGVFQ
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ZN143_BOVIN
Sequence: MLLAQINRDSQGMTEFPGGGMEAQHVTLCLTEAVTVADGDNLENMEGVSLQAVTLADGSTAYIQHNSKDGSAAYVQHVPIPKTTGDSLRLEDGQAVQLEDSYDQSALQAVQLEDGTTAYIHHAVQVPQSDTILAIQADGTVAGLHTGDAAIDPDTISALEQYAAKVSIDGSEGVTGSGIIGENEQEKKMQIVLQGHATRVTAKSQQSGEKAFRCGYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKAFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCHFEGCGRSFTTSNIRKVHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGEDVLKGSQITYVTGVEGDDVVSTQVATVTQSGLSQQVTLISQDGTQHVNISQADMQAIGNTITMVTQDGTPITVPAHDAVISSAGAHSVAMVTAEGTEGQQVAIVAQDLAAFHTASSEMGHQQHSHHLVTTETRPLTLVATSNGTQIAVQLGEQPSLEEAIRIASRIQQGETPGLDD
What is the function of this protein?
Transcriptional activator.  Activates the gene for selenocysteine tRNA (tRNAsec).  Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters.  Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity).
What are the official names of this protein?
Zinc finger protein 143, Selenocysteine tRNA gene transcription-activating factor.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOC2_EUCGG
Sequence: MEVLMAERVNLVFHNKVIDGTAIKRLISRLIDHFGMAYTSHILDQVKTLGFQQATATSISLGIDDLLTIPSKGWLVQDAEQQSLILEKHHHYGNVHAVEKLRQSIEVWYATSEYLRQEMNPNFRMTDPFNPVHIMSFSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGTIRGVSVSPRNGMMPERIFIQTLIGRVLADDIYMGPRCIAIRNQDIGIGLVNRFITFRTQPISIRTPFTCRSTSWICRLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPSNGKIKFNDDLVHPTRTRHGHPAFLCSIDLYVTIESEDILHNVTIPPKSFLLVQNNQYVESEQVIAEIRAGTYTFNLKERVRKHIYSESEGEMHWSTDVYHAPEFTYSNVHLLPKTSHLWILSGGSCRSSRVPFSLYKDQDQMNLRSTERERRYISSLSVNNDQMRYELCSSDFSGKIKEDRIPDYSELNRIISIVHCNLKYPTTFDENSDLLAKRRRNRFLIPLQSIQERKKELMPHSGISIELPINGILRRNSILAYFDDPRYRRKSSGIIKYGTLGVHSVVKKEDLIEYRGIKEFKQKCQMKLDPFFFIPEEVHIFPESSSIMVRNNSLIGVDTRIALNTRSRVGGLVRVERKKKRIELKIFSGDIHFPGETDKISRHSGILIPPGTGKTNFKESKKWKNWIYVQRITPTKKKYFVLVRPVVTYEVLDGINLATLFPPDLLQERDNMQLRVVNYIVYRNGKPIRGISDTSIQLVRTCLILNWDQDKKSSSIEEAHTSFVEVSTNGLIRDFLRIDLVKFPISYLRKRNDPSGSGLISDSDNVSDHTNSNPFYSKTKIQQLLSQNQGTIRTLLNKNKECPSLIILSSSNCFRMGPFNAGKYHNVIKESIKKDPIIKIRNSIGPLGTVLQFVNFYSFYYLITHNPILVTKYLQLENLKQTFQVINYYLMDENGRILNPDSCSNIVLNSFNLNWYFLHHNYYHNYFEERSTIISLGQFICENVCISKNGPHLKSGQVLIVQVDSVVIRSAKPYLATPGATVHGHYGEILYEGDTLVTFIYEKSRSGDITQGLPKVEQVLEVRSIDSISMNLEKRIEGWNEHIKKILGIPWGFLIGAELTIVQSRISLVNKIQKVYRSQGVQIHNRHIEIIVRQITSKVLVSEDGMSNVFLPGELIGLLRAARTGRALEESICYRAILLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVIGGMIPVGTGFKGLVHRSRQHKNIPLKTKKKNFFEGEIGDILFHHRELFDSSISKKFHDTSEQSFRGFNDS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DNLJ_RHOP5
Sequence: MKSKSKTVPDVATLTKAKAKVELMRLALEIERHDKAYYQEDAPKVSDADYDALRRRLEEIEHKFPELVSGASPSQKVGAAPARGFAKVQHAVPMLSLGNAFSDDEVAEFLQRVRRFLNLGDEIPAIVAEPKIDGLSLSLRYEQGELVRAATRGDGSVGEDVTANVRTLKDIPHTLKGNRIPAACELRGEVYMLKSDFLALNKKQEEAGEAPFANPRNSAAGSLRQKDVAITASRPLKFFAYAWGEFSGETPERTQHDMLGWLDHAGFVVNPEITLCHSVDDALVFYRRIGEERAALPYDIDGVVYKVDRLDWQARLGFAGRAPRWAIAHKFAAEQATTILEKIEIQVGRTGALTPVARLAPVTVGGVVVQNATLHNEDYIKGVGNDGQPLREGRDIRVGDTVIIQRAGDVIPQVVDVVLDKRPADAVPYEFPQACPVCGSHAVREDGEVVRRCTGALICPAQAVERLKHFVSRLAFDIDGLGEKQIELFHERGWVKEPVDIFTLKTRNATLKLEELEGYGETSVRNLFAAIDARRTIELHRLIFALGIRHVGEGNAKLLARHYGTIDAFLGAMRAAAAGQTEEGNTSEAYQDLDNIGGIGDIVAEAVVEFFAEERNVEALDALLGELDEVLPAAQVKRDSAVAGKTVVFTGSLSKFTRDEAKAAAERLGAKVAGSVSKKTDFVVAGEDAGSKLTKARELGVSVLSEDEWLALIQG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: Y1185_RICBR
Sequence: MSEVVVKEQLEQYLSKIERLEQEKADLSEEIKDIFQDASSHGFDVKAMKTVLKLKKLDKDKLAEQDAMLELYRDTLGI
What are the official names of this protein?
UPF0335 protein RBE_1185.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: Y2248_MYCTO
Sequence: MTRQQLDVQVKNGGLVRVWYGVYAAQEPDLLGRLAALDVFMGGHAVACLGTAAALYGFDTENTVAIHMLDPGVRMRPTVGLMVHQRVGARLQRVSGRLATAPAWTAVEVARQLRRPRALATLDAALRSMRCARSEIENAVAEQRGRRGIVAARELLPFADGRAESAMESEARLVMIDHGLPLPELQYPIHGHGGEMWRVDFAWPDMRLAAEYESIEWHAGPAEMLRDKTRWAKLQELGWTIVPIVVDDVRREPGRLAARIARHLDRARMAG
What are the official names of this protein?
Uncharacterized protein MT2308.
Protein: RUVC_THERP
Sequence: MRVLGVDPGMALLGYGVVEGGEPLRALSFGVVSTPAHLPVERRLVVLHDELAQLLEHWQPDVVALEQLFFARNVTTALAVGQARGIVLLLCGQRTIPVVEYTPAQVKQAVGGYGRARKREMQEMVRLLLRLPVLPQPDDAADALALAVCYFQYSRAAQLERFT
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: BAKOR_HUMAN
Sequence: MASPSGKGARALEAPGCGPRPLARDLVDSVDDAEGLYVAVERCPLCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSRLKSKQEEFQKEVLKAMEGKWITDQLRWKIMSCKMRIEQLKQTICKGNEEMEKNSEGLLKTKEKNQKLYSRAQRHQEKKEKIQRHNRKLGDLVEKKTIDLRSHYERLANLRRSHILELTSVIFPIEEVKTGVRDPADVSSESDSAMTSSTVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDYSAYYSWVEEKKTTQGPDMEQSNPAYTISAALCYATQLVNILSHILDVNLPKKLCNSEFCGENLSKQKFTRAVKKLNANILYLCFSQHVNLDQLQPLHTLRNLMYLVSPSSEHLGRSGPFEVRADLEESMEFVDPGVAGESDESGDERVSDEETDLGTDWENLPSPRFCDIPSQSVEVSQSQSTQASPPIASSSAGGMISSAAASVTSWFKAYTGHR
What is the function of this protein?
Required for both basal and inducible autophagy.  Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071).  Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597).  Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597).  Enhances PIK3C3 activity in a BECN1-dependent manner.  Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393).  Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393).  Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604).  Modulates the hepatic lipid metabolism (By similarity).
What are the official names of this protein?
Beclin 1-associated autophagy-related key regulator, Barkor, Autophagy-related protein 14-like protein, Atg14L.
What is the protein family that this protein belongs to?
Belongs to the ATG14 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions (PubMed:19050071). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:19050071). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).
Protein: AROD_ECOSM
Sequence: MKTVTVKDLVIGTGAPKIIVSLMAKDIASVKSEALAYREADFDILEWRVDHYADLSNVESVMAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLAGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: METE_STAAN
Sequence: MTTIKTSNLGFPRLGRKREWKKAIESYWAKKISKEELDQTLTDLHKENLLLQKYYHLDSIPVGDFSLYDHILDTSLLFNIIPERFQGRTIDDDLLFDIARGNKDHVASALIKWFNTNYHYIVPEWDNVEPKVSRNVLLDRFKYAQSLNVNAHPVIVGPITFVKLSKGGHQTFEEKVKTLLPLYKEVFESLIDAGAEYIQVDEPILVTDDSESYENITREAYDYFEKAGVAKKLVIQTYFERAHLKFLSSLPVGGLGLDFVHDNGYNLKQIEAGDFDKSKTLYAGIIDGRNVWASDIEAKKVLIDKLLAHTNELVIQPSSSLLHVPVSLDDETLDTSVGEGLSFATEKLDELDALRRLLNQNDSVKYDKLKARYERFQNQSFKNLDYDFESVRTSRQSPFAQRIEQQQKRLNLPDLPTTTIGSFPQSREVRKYRADWKNKRITDEAYETFLKNEIARWIKIQEDIGLDVLVHGEFERNDMVEFFGEKLQGFLVTKFGWVQSYGSRAVKPPIIYGDVKWTAPLTVDETVYAQSLTDKPVKGMLTGPVTILNWSFERVDLPRKVVQDQIALAINEEVLALEAAGIKVIQVDEPALREGLPLRSEYHEQYLKDAVLSFKLATSSVRDETQIHTHMCYSQFGQIIHAIHDLDADVISIETSRSHGDLIKDFEDINYDLGIGLGVYDIHSPRIPTKEEITTAINRSLQQIDRSLFWVNPDCGLKTRKEEEVKDALTVLVNAVKAKRQE
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: TSHR_PIG
Sequence: MSLTPLLQLALLLALPRSLRGKGCPSPPCECHQEDDFRVTCKDIHSIPPLPPNTQTLKFIETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESQSFYNLSKMTHIEIRNTRSLTYINPGALKDLPLLKFLGIFNTGLRIFPDLTKVYSTDVFFILEITDNPYMTSIPANAFQGLCNETLTLKLYNNGFTSVQGHAFNGTKLDAVYLNKNKYLTVIDKDAFGGVFSGPTLLDVSYTSVTALPPKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRSLRQRKSVNAVNGPFYQEYEEDLGDSSVGNKENSKFQDTHSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTQSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYAIMAGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIVAFTIVCSCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGFCKRQAQAYRGQRVSPKNSTGIQVQKVTQNMRQSLPNMQDDYELLENSHLTHKKHDQISKEYKQPVL
What is the function of this protein?
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin.  Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Plays a central role in controlling thyroid cell metabolism.
What are the official names of this protein?
Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein: RECX_ECOSM
Sequence: MTESTSLRPAYARLLDRAVRILAVRDHSEQELRRKLAAPIMGKNGPEEIDATAEDYERVIAWCHEHGYLDDSRFVARFIASRSRKGYGPARIRQELNQKGISREATEKAMRECDIDWCALARDQATRKYGEPLPTVFSEKVKIQRFLLYRGYLMEDIQDIWRNFAD
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUNB_LOCMI
Sequence: HLRNHSGWKPFRCDKCDYQCVNKSMLNSHLKSHSNIYQYRCADCTYATKYCHSLKL
What is the function of this protein?
Gap class segmentation protein that controls development of head structures.
What are the official names of this protein?
Protein hunchback.
What is the protein family that this protein belongs to?
Belongs to the hunchback C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAR14_MOUSE
Sequence: MAELCRMDSTLTALDEEMLWDMLESHRCRIVQSICPSRLTPYLRQAKVLGQLDEEEILHSSRFTNSAMRVGHLLDLLKARGKNGAIAFLESLKFHNPDVYTLVTGLQSDIDFSTFSGLMETSKLTECLAGAISSLQEELAQEKAQKEVLLRRCQQLKERLGLAEAHAEGLRQLEVDHSRMKREVSTHFHEVLKLKDEMLNLSLHYSNALREKELAATRCHSLQEELYLVKQELQRASLVSSCERESRERSLKMASNLEPQGEELNRLKEENEKLRSMTFSLVEKDILEQSLDEARESKQELVDRIHSLRERAVAAERQQKQYWEEKEQTLLQFRKTQVDCELYKEKMTMLQGQVAELQKERDQAYTARDRAQMEISQRLVEKDALRRRVFELTEQVCELRTQLRRLQAEAPGGPKQEAGARELCLRGKQRLVRMHAVCPPDDSDCSLLSSTESRLWWDLNSTSSREQMDSFRSSSPMPPSQQSLYKRVAEDFLEDPESLSFPEVLEMRLQGATVDDTDTDLEFEMIDGADLSQTEDSLQGSSRSLNVSESSVPVRRRPARKILSQVTVLAFQGDALLEQIGVIGGNLTGIFIHRVTPGSAADEMALRPGTQIMMVDYKPTKPSLRATLENTTLEQAVGLLRRVNGSCYLSVKINTEGYKNLIQDLDAKVVTSGDSFYIRVNLAMQRGGDGELQTHCNDILHVTDTMFQGRSCWHAHHVNPYTMKDMEPGTIPNYSQAQQQLLALIQDMTQRCTVPRKPPGGPQKLVRIVSVDKAAVSPLTSSFDQSQWDSGKEEGGPSVCFWSESCFTLAPYTLVHPHRPARPRPVLFVPRLVGRILGKKLCLLQGFKQCSAEYLSQEEYATWSQRGDIIQEGESIGDHHWITRHAVESLMNMSTHALLDVRLDSVRVLHRMDMFPIIIHVSVNEKTAKKLRKGLHRLGSSEEQFLEVARQEEGELDRVPCLYSSLAPDSWSDLDSLLSCVRLAIADEQKKVVWTESPC
What is the function of this protein?
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways.  Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression.  MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases.  May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.
What are the official names of this protein?
Caspase recruitment domain-containing protein 14, Bcl10-interacting MAGUK protein 2, Bimp2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPIKE_IBVU2
Sequence: NLFGNNSYVYYYQSAFRPPDGWHLHGGAYEVVNVSTEFSNAGTTGCTAGAIYWSKNFSAASVAMTAPQNGMSWSTQEFCTAHCNFTDFVVFVTHCYKSGHGFCPLTGLIPQNYIRISAMKNSSLFYNLTVAVTKYPRFKSLQCVNNMTSVYLNGDLVFTSNETKDVSAAGVHFKAGGPITYKVMREVKALAYFVNGTAQDVILCDGSPTGLLACQYNTGNFSDGFYPFTNSSLVKEKFIVYRESSVNTTLELTNFTFSNVSNATPNTGGVQTIQLYQTITAQSGYYNLNFSFLSSFIYKASDYMYGSYHPRCKFRLETINNGLWFNSLSVSLGYGPIQGGCKQSVFENRATCCYAYSYNGPSLCKGVYRGELTKSFECGLLVFVTKTDGSRIQIRNEPLTLTQHNYNNITLDRCVEYNIYGRVGQGFITNVTNYAINYNYLADGGMAILDTSGAIDIFVVQGEYGLNYYKVNPCEDVNQQFVVSGGKLVGILTSRNETGSQPLENQFYIKIINGTRRSRR
What is the function of this protein?
S1 attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses spike protein family.
What are the subcellular locations of this protein?
[Spike protein S1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. S1 is not anchored to the viral envelope, but associates with the extravirion surface through its binding to S2 (By similarity).
Protein: STFQ_ECOLI
Sequence: MNITALTDNTQGAAGLELYEVYNNGYPTAYGNIIHLKGMTAVGEGELLIGWSGTSGAHAPAFIRSRRDTTDANWSPWAQLYTSAHPPAEFYPVGAPIPWPSDTVPSGYALMQGQTFDKSAYPKLAVAYPSGVIPDMRGWTIKGKPASGRAVLSQEQDGIKSHTHSASASSTDLGTETTSSFDYGTKSTNNTGAHTHSISGTANSAGAHQHKSSGAFGGTNTSIFPNGYTAISNLSAGIMSTTSGSGQTRNAGKTSSDGAHTHSLSGTAASAGAHAHTVGIGAHTHSVAIGSHGHTITVNAAGNAENTVKNIAFNYIVRLA
What are the official names of this protein?
Prophage side tail fiber protein homolog StfQ, Side tail fiber protein homolog from lambdoid prophage Qin.
What is the protein family that this protein belongs to?
Belongs to the tail fiber family.
Protein: SEC11_ASPFC
Sequence: MLSFLSSNLSSTRQSMAQVLNFALVLSTAFMLWKGLSVFTASSSPIVVVLSGSMEPAFQRGDLLFLWNRSPRAELGEIVVYNVRGKDIPIVHRVVRTFPQIEGKAKKVKEVNEASSVPPNMLLTKGDNNIADDTELYAKNQDFLHREEDIVGSVRGYMPMVGYVTIMLSEHPWLKTVLLGIMGLMVILQREQ
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit sec11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.