PharMolix/UniProtQA huggingface dataset:
Protein: SPG7_HUMAN
Sequence: MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTSGAQDDLRKVTRIAYSMVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRHTEKVLQDNLDKLQALANALLEKEVINYEDIEALIGPPPHGPKKMIAPQRWIDAQREKQDLGEEETEETQQPPLGGEEPTWPK
What is the function of this protein?
ATP-dependent zinc metalloprotease.  Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (PubMed:26387735).
What are the official names of this protein?
Paraplegin, Cell matrix adhesion regulator, Spastic paraplegia 7 protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL30_METTH
Sequence: MFAVVRVRGSAGVRRDIADTMEMLRLNRINHAVLVEDTPSYLGMLQKAKDYITWGEVDQETLTAMIRKRGRLIGGDRITDEYINEKTAYGSVDEFAAAVFSGEVKLEEAGIKPVFRLHPPRKGYEGIKKAFNEGGSLGYRGEKINDLLKRMI
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: L_SYNV
Sequence: MEGMDHWENAKYFQGIEDIEEDTRQPTVDSMSSGTYHCKSALRSHKDNMKLFLYRRDFLIFSHRFNGLPYDEQYLGVLPKLWSCFYDKTHDLSGFLDQYASREHCTPSDSFSRWADPTVLHLYDDPIIRNLLASENKVLNFLEGGISDILDKYQICIKRNIRLIYLHLFLNLALIVLNHTDADSMPDRRVELNGVTFKLEEGVILCEYNEYLKIYVLKGAVIWDMPAYRQVLQKDLFLTICDKISERINIVIGATIITALSHKTNLDDPDSHLYDACINMIKIGDNILVNHGNRGFDLLGKFEAYCVACILTYDDQRIWNPLEFLNNLIEDDRINQPDLYNDANNLVAFLRKQPIVILAELHGLWRIWGHPIIDLEGGMKKMEATCTKQSPVSVEETRVCERTMKLTFFTNYYDKHHHYPLSTLTHPDHFNLYSQYLSERDKIEYLANKDIAFEHSYIMRCIRRNKKIFQRSSLYNHKDWDQVVILQSFQIPKSVNLATMIKDKAISMTRSELIESVNTKNSVFDSTKRRGILKWLNEQSDKIYNFLMRIDDKGLDEDDCIIGLYPKEREMKTKARFFSLMSYKLRMYVTSTEELLGKYVLKYFPMITMSDNLLSMVIRLFDMTTLIGDKGVAVTYSMNIDFSKWNQNMRERTNAGIFDNLDRILGFRSLISRTHSIFKACYLYLCSGEYVPVISNNQLTAQSPWSRTGDESGKEGLRQKGWTITTVCDILSLAFKYNARIQLIGGGDNQVLTVTMLPSESMQSQGRDSQLLKVRERMTSFRNALAKKMVKRGLPLKLEETWISHNLLMYNKIMYYSGVPLRGRLKVISRLFSNSNVGVTSLGGITSTLGTGFQSISTKDYTPTLAWLISRVFTDIYISTYHLLNPISGTQRLDKQVLMSRGNIRQGRNELGGETSVPIINKIRNHAALATDHTLDLDSLLICVLYYHKILGGPGIGPPTAYVMKGFPDPLSEGLTFNYLVITNVLNERTKRKIISVTKVMKNRNQHWEHLLEDPVSVNHDAPPHGIAALRAQAEAVMRSAKITNIGFKNLIDIGDNQYLRDLSEKLCSPNDLEPRLLHDIVGSTIPGFVNSVLSRVDQSTTINKIAGNSDVVTSIYLSEMSYYLYLSKKVNTQDGHAIGSCPTRDSKMLRNWTWGKNIIGVTTPHPLGYLKRERHSESSSCDNNYIRVLTKRIGNSWELRRGQFRPYFGSYTEEKFKMTTLASAYGDESILKRAIKIQKLLGWRYHQGSSLYNLIQKILTCVTDADPNKFLPLPDEITGDVEHRYHDMATKHGGIPSNLIHLYTHASCNTSTFINHSKGAANESLHFQAAIIWTCMQSICRTSASSSVSDISHYHEACNQCIVKLEDPIESDYSTSDISLMSCPANDLMYVKEDDIPVHFHTTMEFYRASSSSTVLKKIKKIEDAEVISSRMTWVVTLCSHLLNQDTIKHSTWKLISEDLSKEEVMFIVMSITMYIMSEQDIPVHSASLSDFRTLYEKNKDIIDRVLGIEALNDAVSGVSFYNNRCSDDQCLRWKETSDQILSHYKTTGTCAVKYQAPHFRICTRLVYLMTNPSCQSCPCCLGVIKDDSNDGPIMCQLHGELAGPCGYHLCSLDKLNKTKKGLNMSKVFYTDGTISAQHDAKNRPTKKRPHGENSLTEMFKRAKTSRENRILKQNKESYLFIQPRLMVDLFIDMGSMWEKTQISDQGSHIIPAHTNPIVLSKKSDLYVPAAISKFVSNGFLIMDAVERALGKPSKPITEHSQLSVNISYGIEYHPEIKRETVQLLRFVNELAYTGYGGGVTICITLFPIFISDIEAVDPRLISDIIYRYRADSSDYACIRLTDMGDMCFDINNILSDCDACLSYDPGCWSQDANLVYIISDTSDIMIKAKEFETLHSFNKFYSVECLAPRFFMSSSTVSALVISKSSSINSIDYDRLAEIHLDRRGTQMWDLSRLFANMTMRDGLTEMIKCIYNNVSGEATILTSQSLVDAAISKIKVDILRGLIDMVRGERMNWRTQYMIQILLGVMILTSDNPEDYRREISKYNNAVVLLQKPRRIKLIRDHLGGADRKFYHATTNNGLLGSSLNDVTHILEGILYITHRTSRKLCTSISLEV
What is the function of this protein?
RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA.  The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N).  The replicase mode is dependent on intracellular N protein concentration.  In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
What are the official names of this protein?
RNA-directed RNA polymerase L, Protein L, Large structural protein, Replicase, Transcriptase.
What is the protein family that this protein belongs to?
Belongs to the rhabdoviridae protein L family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=L and P are packaged asymmetrically towards the blunt end of the virus.
Protein: IL18R_MOUSE
Sequence: MHHEELILTLCILIVKSASKSCIHRSQIHVVEGEPFYLKPCGISAPVHRNETATMRWFKGSASHEYRELNNRSSPRVTFHDHTLEFWPVEMEDEGTYISQVGNDRRNWTLNVTKRNKHSCFSDKLVTSRDVEVNKSLHITCKNPNYEELIQDTWLYKNCKEISKTPRILKDAEFGDEGYYSCVFSVHHNGTRYNITKTVNITVIEGRSKVTPAILGPKCEKVGVELGKDVELNCSASLNKDDLFYWSIRKEDSSDPNVQEDRKETTTWISEGKLHASKILRFQKITENYLNVLYNCTVANEEAIDTKSFVLVRKEIPDIPGHVFTGGVTVLVLASVAAVCIVILCVIYKVDLVLFYRRIAERDETLTDGKTYDAFVSYLKECHPENKEEYTFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNGARRELESGLHEALVERKIKIILIEFTPASNITFLPPSLKLLKSYRVLKWRADSPSMNSRFWKNLVYLMPAKAVKPWREESEARSVLSAP
What is the function of this protein?
Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B.  Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity).  Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (PubMed:26099046).
What are the official names of this protein?
Interleukin-18 receptor 1, IL-18R-1, IL-18R1, CD218 antigen-like family member A, IL1 receptor-related protein, IL-1Rrp, IL1R-rp, Interleukin-18 receptor alpha, IL-18R-alpha, IL-18Ralpha.
What is the protein family that this protein belongs to?
Belongs to the interleukin-1 receptor family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: DCUP_BRUAB
Sequence: MNRKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHALGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGFPKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGITPQAPIENVQRMIDRVRGGKS
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBTD1_DANRE
Sequence: MGGCVGRERAETRGRGSRTQRKRGGRNEPLKKDKPKWKSDYPMTEGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAVALECSDHELAQAIVDGANITLPHGSLTECYDELGNRYQLPVYCLAPPVNLISERSEEDLTDNPEPQTAQKKEFQLKVRLSTGKDLRLNASMSDTIGLLKKQLQAQEDIDISHQRWFFSGKLLTDKTRLQDTKIQKDFVIQVIVNQPAPNH
What is the function of this protein?
May be involved in the regulation of cellular senescence through a positive feedback loop with TP53.
What are the official names of this protein?
Ubiquitin domain-containing protein 1.
Protein: SMR1_RAT
Sequence: MKSLYLIFGLWILLACFQSGEGVRGPRRQHNPRRQQDPSTLPHYLGLQPDPNGGQIGVTITIPLNLQPPRVLVNLPGFITGPPLVVQGTTEYQYQWQLTAPDPTPLSNPPTQLHSTEQANTKTDAKISNTTATTQNSTDIFEGGGK
What is the function of this protein?
Sialorphin is an endogenous inhibitor of neprilysin.  Inhibits the breakdown of Met-enkephalin and substance P in isolated tissue from the dorsal zone of the rat spinal cord.  Has an analgesic effect when administered to rats by intravenous injection.
What are the official names of this protein?
SMR1 protein, VCS-alpha 1.
Protein: ESL2_YEAST
Sequence: MPETSVQNPLRLSENENTRSMFLSASQQQRPSATPSFPRLVRNTTANLSLSDFQVLNPSSKRQNSNSVYDDINSSKRRISRPRFSDIEGKNNDHTYPERTTVKESEKNPSPRYVSSSKRALKRENSVGITQSSALISKSFSENGGSIAHEKWSPENMIKPLNVSQNSLAFVDAGSDEQSKSEIVGGFQRKSNNSQEINDKDNSARDQDFNNSGNNNNNNNHSSNNNDNNNNNNDDNNNNNNSNSRDNNNNSDDSNEREENDSCKPASNKRSGIALIQKLQELYKVIVKQEIELQERCSQLTNSQTTELKSLWTIYKINTDLVNNYVTFITTALLPSQPPHDLVIGQEIVEIYRIERRLWVYGTITFLDVLKNFSNFMDPEVCCQFITHVFVSLSTMISDIPSKYSITWLQRLGDLSRMAIALYPSSFIDWKLSAEHWYTEAMKYIYNHGKLYYHMSTVQQNTLEAFVNLGKSVFCQETFTPSPQYMQLVIDNIYQRAFVERNNGNLRNSLLIEYLKHSEAMLLPSFLESPDLQNVVLSYFIEKFGIDANGCNIFNAEDMFVQNPDFFKYFFRHGPSFAQSHILQIVGFGEPKNPFAILFELPKYLKERKDKKERKKSSNNDSSVTESSTGNSRNDNEDDDEIMSSTTSISDHDLLAEFFNDIDTLRRPILPSMLTNEAWLETLKFLNMTSLKCGIIVLRKFLHGPLGIALPHILPWIYFIISICLKSSQLSDPVSKEFWMIIVKRAFPWDTMVTFMNVLIVYLLDNQTSNSIIGDLCDDYDKLSLSELLELFNEGEELPEILGCWGTLWFDTICEKNTHSISSEDNFQEIGIKDYMALDSPTDGIIFDEKDENGEKFWKRACRTIFLFRELSRSFPIGVIIRNDPLIYRSSFQNTNILGSLVFKLEPLCNIHNNIPVLGALESIIDISEARSENNTDLHAVPELSVNEGDNIFHYVGYKKLRADYTCFDKNGEFLSASLYTTWYVPNSNNTNIEDNINYNSEKENEGLFLECIKSDYPEIDFKTTYFVFDATSWLRHSARIFKLAQNRLLRFAICLTTFQELRFLRKSKDENVMEAATRGIITIRQLYYENKVLPLRFTGNVATHIEENLEFEEQITWRTHVDEFVIESVMKAQEKLESASEPRLSPRRFNYVVLISDDDAMKKKAEEKEIKTLSTRFVFSLCTKLGEQRHLCTD
What is the function of this protein?
May be involved in the regulation of gene expression responses of environment-sensing pathways.
What are the official names of this protein?
EST/SMG-like protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Peroxisome. Note=A fraction of the protein co- localizes with peroxisomes.
Protein: ENOPH_YEAST
Sequence: MGDNYSTYLLDIEGTVCPISFVKETLFPYFTNKVPQLVQQDTRDSPVSNILSQFHIDNKEQLQAHILELVAKDVKDPILKQLQGYVWAHGYESGQIKAPVYADAIDFIKRKKRVFIYSSGSVKAQKLLFGYVQDPNAPAHDSLDLNSYIDGYFDINTSGKKTETQSYANILRDIGAKASEVLFLSDNPLELDAAAGVGIATGLASRPGNAPVPDGQKYQVYKNFETL
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase, Unknown transcript 4 protein.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GLPK_LEIXX
Sequence: MAEYIVAIDQGTTSTRAIIFDKSGSIVSTGQLEHEQIFPKPGWVEHNPVEIWNNTREVIGQALSKADLTRHDIAAVGITNQRETAVVWDKNTGEPVYNAIVWQDTRTQPIVDRLAAEGGVERFKPIVGLPLATYFSGTKIVWILENVEGVRERAERGDLLFGTTESWVLWNLTGGTDGGVHATDVTNASRTLFMDLETLSWRDDILDVFGVPKSMLPEIKSSSEVYGAVESSSLLREVPVAGILGDQQAATFGQAAFDPGESKNTYGTGNFLIFNTGEEIVHSKNGLLTTLGYKLGDGKPHYALEGSIAVTGSLVQWLRDNLGVISSAPEIEELAQTVEDNGGAYFVPALSGLFAPYWRADARGALVGLTRYVNKGHIARAALEATAFQTREVLDAVNADSGVDLTELKVDGGMIANNTLMQFQADILGVPVVRPVVAETTALGAAYAAGLATGFWENLDDLRKNWKEDRRWEPKMDAAERDRQLRLWKKAVTKTFDWVDDDVRNG
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: PERN1_TOBAC
Sequence: MEYYHHSINKMAMFMVILVLAIDVTMVLGQGTRVGFYSSTCPRAESIVQSTVRAHFQSDPTVAPGILRMHFHDCFVLGCDGSILIEGSDAERTAIPNRNLKGFDVIEDAKTQIEAICPGVVSCADILALAARDSVVATRGLTWSVPTGRRDGRVSRAADAGDLPAFFDSVDIQKRKFLTKGLNTQDLVALTGAHTIGTAGCAVIRDRLFNFNSTGGPDPSIDATFLPQLRALCPQNGDASRRVGLDTGSVNNFDTSYFSNLRNGRGVLESDQKLWTDASTQVFVQRFLGIRGLLGLTFGVEFGRSMVKMSNIEVKTGTNGEIRKVCSAIN
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.  Can use NADH, NADPH and monolignols as substrates.
What are the official names of this protein?
Peroxidase N1, Peroxidase B2, Peroxidase B3.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LAX2_ARATH
Sequence: MENGEKAAETVVVGNYVEMEKDGKALDIKSKLSDMFWHGGSAYDAWFSCASNQVAQVLLTLPYSFSQLGMLSGILFQLFYGILGSWTAYLISILYVEYRTRKEREKVNFRNHVIQWFEVLDGLLGKHWRNVGLAFNCTFLLFGSVIQLIACASNIYYINDNLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLLMTTYTAWYLTIASILHGQVEGVKHSGPSKLVLYFTGATNILYTFGGHAVTVEIMHAMWKPQKFKSIYLFATLYVLTLTLPSASAVYWAFGDLLLNHSNAFALLPKNLYRDFAVVLMLIHQFITFGFACTPLYFVWEKLIGMHECRSMCKRAAARLPVVIPIWFLAIIFPFFGPINSTVGSLLVSFTVYIIPALAHIFTFRSSAARENAVEQPPRFLGRWTGAFTINAFIVVWVFIVGFGFGGWASMINFVHQIDTFGLFTKCYQCPPPVMVSPPPISHPHFNHTHGL
What is the function of this protein?
Carrier protein involved in proton-driven auxin influx.  Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex (By similarity).
What are the official names of this protein?
Auxin transporter-like protein 2, AUX1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.1) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL13_BEUC1
Sequence: MRTFTPKPSDTERTWYVIDATDVVLGRLASQVAKLLRGKHKATFAPHVDTGDFVIVVNADKVALTGNKEQQKLAYRHSGYPGGLKATSYAELLEKRPERAVEKAIRGMVPKNSLGRAQMRKLKVYAGAEHPHGAQKPQTFEITQIAQ
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: YJ87_SCHPO
Sequence: MEPSQRSGSFSSISRRRSRVDSRPTYFKVTSKDLGFVDQVSEEYEFYTYPKKASEVESVTETFQSNRSSLVPTYPVDENANKLPPKVSIAFILINSLMSDMSLAVALPTSASYTQSLGGTNAFSGLVIGIPTLISLIFLYPMLCFANPKSANGYTLYFRPMVVSSFAHIFGHLLYCMAYRANWIYLILIGRMLNGIGFTTFLYHKKYTTDKLLVGQNRRTFLATMNILAQTLGFMAGPFLGGILAKATIHSKNAVWNQYTVASWVMLFMWFFYMLTIIFFFKEVTADKSEKVSQQKENDDEDRPKLSWKHKFLLFFLAEVAFIAYFTVNGYQASISIYTGKLYNYDAFQSGNFIALSALIVAPFILASSFLSRWLEDRHIMLGGLFLGILAVAIHLVLDAVHKLPMQVYFFLYSLMIYGYSIGSAPLISLSSKQLHPRHHNTASIVVQVGVSLSNTFGSICGGAIYNITTVGFISLCLGLAAVVYMQLIFMWGSLKCKTH
What are the official names of this protein?
Uncharacterized MFS-type transporter C330.07c.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Golgi apparatus. Membrane; Multi-pass membrane protein. Note=Barrier septum. Cell tip.
Protein: VMA21_ASHGO
Sequence: MAVDVPTSVIVKLMFFTLAMVSFPVLTFFVSQQYTSNTLVNGGLAALAANVVLFAYVIMAFSEDVPQSDGKESKKQQ
What is the function of this protein?
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
What are the official names of this protein?
Vacuolar ATPase assembly integral membrane protein VMA21.
What is the protein family that this protein belongs to?
Belongs to the VMA21 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Protein: ACKA_BACLD
Sequence: MSKIIAINAGSSSLKFQLFEMPSEKVLTKGLVERIGLDNGIFTISVNDEKKTETTDIPDHSVAVKMLLDKLTKFGIIKDLNEIDGIGHRVVHGGEKFSDSVLLTDEMIHEIEEISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLYSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPIEELRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRSGNIDPALIPFIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENSVEVRERVLHGLEFMGVYWDPALNNVRGKEAFISYPHSPVKVIVIPTNEEVMIARDVVRLAH
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_WICCA
Sequence: MYIQRWLYSTNAKDIAILYFIFAIFSGVIGSTMSLIIRLELAAPGNQILHGNHQLFNVLVVGHALLMIFFLVMPGLVGGFGNYMLPLLIGASDMSFARLNNISFWLLPPALVCLVASTLIESWAGTGWTIYPPLSGIQAHSSPSVDLGIFAIHLTSISSLLGAINFIATSYNMRTNGMSYSKMPLFVWAIIITAVMLLLSLPVLTAGVTMLLMDRNFNTSFFEVAGGGDPVLYQHLFWFFGHPEVYILIVPGFGIISHIVSTYSKKPVFGEISMVYAMASIAFLGFLVWSHHMYIVGLDADTRAYFTSSTMVIAVPTGIKIFSWLATLYGGSIRLAVPMLYAIAFLFLFTIGGLTGVALANASLDVAFHDTYYVVGHFHYVLSMGAIFSLFAGYYYWSPQILGLYFNERLAQIQFWLIFVGANVIFMPMHFLGLQGMPRRIPDYPDAYAGWNYVSSIGSVIAIISLALFIYIIYDQLINGLTNKIDNKSVVYSKAPDFVESNTIFANNSIKSASIEFLLNSPPAIHSFNTPAVQS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DJC21_BOVIN
Sequence: MKCHYEALGVRRDASEEELKKAYRKLALKWHPDKNLDNAAEAAEQFKLIQAAYDVLSDPQERAWYDNHREALLKGGLDGEYQDDSLDLLHYFTVTCYSGYGDDEKGFYTVYRNVFEMIAKEELESALEEDMEDFPTFGDSQSDYDTVVHPFYAYWQSFCTQKNFAWKEEYDTRQASNRWEKRAMEKENKKIRDKARKEKNELVRQLVAFIRKRDRRVQAHRKLVEEQNAEKARKAEAMRRQQKLKQAKLAEQYREQSWMAVADLEKELREMEAQYEKQFGDGSGEDEAEDQELRDGQDGKDSDEAEDAELYDGLYCPACDKSFKTEKAMRNHEKSKKHREMVALLKQQLEEEEANFSGPQTDENSLNANSEEEMEDAPKQKLSRKQKKKKQKPAQNYDDNFNENGIGEGVKIDPEDTNLNQNSAKESEDSLQENVGVTETVELCDDPKTEAKSVSKPKGKKAKDTKKSVRVPAEPQTMSDVLISCTTCHSEFPSRNKLFDHLKATGHARAPSSSTSLNSVTNSRNKKEKRKNR
What is the function of this protein?
May act as a co-chaperone for HSP70.  May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit.  Binds the precursor 45S rRNA.
What are the official names of this protein?
DnaJ homolog subfamily C member 21.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Within the nucleus, localizes primarily to the nucleolus.
Protein: NH2L1_MOUSE
Sequence: MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQQSIERLLV
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Involved in pre-mRNA splicing as component of the spliceosome.  Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly.  The protein undergoes a conformational change upon RNA-binding.
What are the official names of this protein?
NHP2-like protein 1, Fertilization antigen 1, FA-1, High mobility group-like nuclear protein 2 homolog 1, Sperm-specific antigen 1, U4/U6.U5 small nuclear ribonucleoprotein SNU13, U4/U6.U5 tri-snRNP 15.5 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=Concentrated in the dense fibrillar component of the nucleolus.
Protein: RNPA_STRMU
Sequence: MKKAYRVKSDKDFQAIFTEGRSVANRKFVVYSLEKDQSHYRVGLSVGKRLGNAVVRNAIKRKLRHVLMELGPYLGTQDFVVIARKGVEELDYSTMKKNLVHVLKLAKLYQEGSIREKEI
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL28_YERPB
Sequence: MSRVCQVTGKRPMSGNNRSHAMNATKRRFLPNLHSHRFWVEGEKRFVTLRVSAKGMRVIDKKGIETVLAEIRARGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: YHS7_YEAST
Sequence: MARNRTTSKKNVQSKRLIDRVVPMDKIKKVGVAKKKTVEHTKEGFSVVNGKLVSSNDVGVLLREAQGAIDKRTNVSQRNRKKGIKNNRPHKDINSSPDWGNAHRGTDWQSEKANGMNRAKNSRNFTTNIKLQRQHFGEEIQGGSQLVISTNSDASDKLLMLFNLTLGVNQENLKNVLENISQVQIAQIRVRDLPSGSATAKVRLAYPTTQSLEKVRKLFHGALVDGRRIQVVIASDESSHLSY
What are the official names of this protein?
Uncharacterized protein YHR127W.
Protein: DNLI_SULIN
Sequence: MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKAIIDKVVYIIQGKLWPDFLGYPELGIGEKFLIKAISIATNTDENSVENLYKSIGDLGEVARRLKSKQQSTGILGFLGTSSKESLKVDKVYSTLSKVALTTGEGSRDLKIRLLAGLLKKADPLEAKFLVRFVEGRLRVGIGDATVLDAMAIAFGGGQSASEIVERAYNLRADLGNIAKIIVEKGIEALKTLKPEVGIPIRPMLAERLSNPEEILKKVGGSALVDYKYDGERAQIHKKDDKIFIFSRRLENITSQYPDVVEYISKYTEGKEFIIEGEIVAVDPESGEIRSFQELMHRKRKSDIYEAIKEYPVNVFLFDLMYYEDVDYTTKPLEVRRKLLESIVKPNDYVKIAHHIQVNNVEDLKSFFYRAISEGGEGVMVKAIGKDAIYQAGARGWLWIKLKRDYQSEMADTVDLVVVGGFYGKGKRGGKISSLLMAAYNPKTDTFESVCKVASGFSDEQLDELQKKLMEIKRDIKHPRVNSKMEPDIWVEPVYVAEIIGAEITISPLHTCCQDVVEKDAGLSIRFPRFIRWRDDKSPEDATTTDEILEMYNKQPKKKIESPPIDESV
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.