PharMolix/UniProtQA huggingface dataset:
Protein: SASA_SYNJB
Sequence: MQTSPDLTSARSVIRLLLFAKSRAVVAELEEHLRQHIQGLPGQYPAQLEVVPLEEHPYLAEHYKLVATPALVKAEPLPAQVLAGADLATQLEVWWPRWQGQAALAAHQEGAGRDPASPPTTEALLQMSEEVFLLRQERAQLREQLDFKDRVLAMLVHDLRSPLTATALAVETLQQGREGSLDKALERQLFDHARQQLRKMDSMITDILESARGAASELRIRAVETQLPGLCQAVIEELWPRIQGKRLQFQADIPVDLPSVHVDPDKIRQVLFNLLDNAIKYTPAGGSIRLDVLHRTSQKVQVTVSDTGPGIPEADQESIFSDSVRLSRDQQQEGYGIGLSLCRRIVRAHYGQIWVESSLGKGSSFHFTLPVYRLCKR
What is the function of this protein?
Member of the two-component regulatory system SasA/RpaA involved in genome-wide circadian gene expression.  One of several clock output pathways.  Participates in the Kai clock protein complex, the main circadian regulator in cyanobacteria, via its interaction with KaiC.  KaiC enhances the autophosphorylation activity of SasA, which then transfers its phosphate group to RpaA to activate it.  In addition to its output function, recruits fold-shifted KaiB (KaiB(fs)) to KaiC to cooperatively form the KaiB(6):KaiC(6) complex (independent of SasA kinase activity).  Required for robustness of the circadian rhythm of gene expression and is involved in clock output, also required for adaptation to light/dark cycles.
What are the official names of this protein?
Adaptive-response sensory kinase SasA, Sensor histidine kinase SasA.
Protein: RL29_TETTH
Sequence: MAKSKNSTNKNQISKSHRNGIKKPKDHRHISTKGVNPRFLRNRRRAIKNDPSIKKSKNLEKKVNKE
What are the official names of this protein?
60S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL29 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_STRP8
Sequence: MKKTYRVKREKDFQAIFKDGKSTANRKFVIYHLNRGQDHFRVGISVGKKIGNAVTRNAVKRKIRHVIMALGHQLKSEDFVVIARKGVESLEYQELQQNLHHVLKLAQLLEKGFESEEKH
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: WZXE_SHIFL
Sequence: MSLAKASLWTAASTLVKIGAGLLVGKLLAVSFGPAGLGLAANFRQLITVLGVLAGAGIFNGVTKYVAQYHDNPQQLRRVVGTSSAMVLGFSTLMALVFVLAAAPISQGLFGNTDYQGLVRLVALVQMGIAWGNLLLALMKGFRDAAGNALSLIVGSLIGVLAYYVSYRLGGYEGALLGLALIPALVVIPAAIMLIKRGVIPLSYLKPSWDNGLAGQLSKFTLMALITSVTLPVAYIMMRKLLAAQYSWDEVGIWQGVSSISDAYLQFITASFSVYLLPTLSRLTEKRDITREVVKSLKFVLPAVAAASFTVWLLRDFAIWLLLSNKFTAMRDLFAWQLVGDVLKVGAYVFGYLVIAKASLRFYILAEVSQFTLLMVFAHWLIPAHGALGAAQAYMATYIVYFSLCCGVFLLWRRRA
What is the function of this protein?
Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA).
What are the official names of this protein?
Lipid III flippase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MOEB_ECOLI
Sequence: MAELSDQEMLRYNRQIILRGFDFDGQEALKDSRVLIVGLGGLGCAASQYLASAGVGNLTLLDFDTVSLSNLQRQTLHSDATVGQPKVESARDALTRINPHIAITPVNALLDDAELAALIAEHDLVLDCTDNVAVRNQLNAGCFAAKVPLVSGAAIRMEGQITVFTYQDGEPCYRCLSRLFGENALTCVEAGVMAPLIGVIGSLQAMEAIKMLAGYGKPASGKIVMYDAMTCQFREMKLMRNPGCEVCGQ
What is the function of this protein?
Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD.
What are the official names of this protein?
Molybdopterin-synthase adenylyltransferase, MoaD protein adenylase, Molybdopterin-converting factor subunit 1 adenylase, Sulfur carrier protein MoaD adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the HesA/MoeB/ThiF family.
Protein: RL14_CHLPN
Sequence: MIQQESQLKVADNTGAKKVKCFKVLGGSRRRYATVGDVIVCSVRDVEPNSSIKKGDVIKAVIVRTRRHITRKDGSTLKFDTNSCVIIDDKGNPKGTRIFGPVAREIRDRGFIKISSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MSH6_ARATH
Sequence: MAPSRRQISGRSPLVNQQRQITSFFGKSASSSSSPSPSPSPSLSNKKTPKSNNPNPKSPSPSPSPPKKTPKLNPNPSSNLPARSPSPGPDTPSPVQSKFKKPLLVIGQTPSPPQSVVITYGDEVVGKQVRVYWPLDKKWYDGSVTFYDKGEGKHVVEYEDGEEESLDLGKEKTEWVVGEKSGDRFNRLKRGASALRKVVTDSDDDVEMGNVEEDKSDGDDSSDEDWGKNVGKEVCESEEDDVELVDENEMDEEELVEEKDEETSKVNRVSKTDSRKRKTSEVTKSGGEKKSKTDTGTILKGFKASVVEPAKKIGQADRVVKGLEDNVLDGDALARFGARDSEKFRFLGVDRRDAKRRRPTDENYDPRTLYLPPDFVKKLTGGQRQWWEFKAKHMDKVVFFKMGKFYELFEMDAHVGAKELDIQYMKGEQPHCGFPEKNFSVNIEKLVRKGYRVLVVEQTETPDQLEQRRKETGSKDKVVKREVCAVVTKGTLTDGEMLLTNPDASYLMALTEGGESLTNPTAEHNFGVCLVDVATQKIILGQFKDDQDCSALSCLLSEMRPVEIIKPAKVLSYATERTIVRQTRNPLVNNLVPLSEFWDSEKTIYEVGIIYKRINCQPSSAYSSEGKILGDGSSFLPKMLSELATEDKNGSLALSALGGAIYYLRQAFLDESLLRFAKFESLPYCDFSNVNEKQHMVLDAAALENLEIFENSRNGGYSGTLYAQLNQCITASGKRLLKTWLARPLYNTELIKERQDAVAILRGENLPYSLEFRKSLSRLPDMERLIARMFSSIEASGRNGDKVVLYEDTAKKQVQEFISTLRGCETMAEACSSLRAILKHDTSRRLLHLLTPGQSLPNISSSIKYFKDAFDWVEAHNSGRVIPHEGADEEYDCACKTVEEFESSLKKHLKEQRKLLGDASINYVTVGKDEYLLEVPESLSGSVPHDYELCSSKKGVSRYWTPTIKKLLKELSQAKSEKESALKSISQRLIGRFCEHQEKWRQLVSATAELDVLISLAFASDSYEGVRCRPVISGSTSDGVPHLSATGLGHPVLRGDSLGRGSFVPNNVKIGGAEKASFILLTGPNMGGKSTLLRQVCLAVILAQIGADVPAETFEVSPVDKICVRMGAKDHIMAGQSTFLTELSETAVMLTSATRNSLVVLDELGRGTATSDGQAIAESVLEHFIEKVQCRGFFSTHYHRLSVDYQTNPKVSLCHMACQIGEGIGGVEEVTFLYRLTPGACPKSYGVNVARLAGLPDYVLQRAVIKSQEFEALYGKNHRKTDHKLAAMIKQIISSVASDSDYSASKDSLCELHSMANTFLRLTN
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Forms the heterodimer MutS alpha (MSH2-MSH6 heterodimer) which binds to DNA mismatches thereby initiating DNA repair.  MutS alpha recognizes single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA.  Is involved in a UV-B-induced DNA damage response pathway.
What are the official names of this protein?
DNA mismatch repair protein MSH6, AtMSH6, MutS protein homolog 6.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NMPC_ECOLI
Sequence: MKKLTVAISAVAASVLMAMSAQAAEIYNKDSNKLDLYGKVNAKHYFSSNDADDGDTTYARLGFKGETQINDQLTGFGQWEYEFKGNRAESQGSSKDKTRLAFAGLKFGDYGSIDYGRNYGVAYDIGAWTDVLPEFGGDTWTQTDVFMTQRATGVATYRNNDFFGLVDGLNFAAQYQGKNDRSDFDNYTEGNGDGFGFSATYEYEGFGIGATYAKSDRTDTQVNAGKVLPEVFASGKNAEVWAAGLKYDANNIYLATTYSETQNMTVFADHFVANKAQNFEAVAQYQFDFGLRPSVAYLQSKGKDLGVWGDQDLVKYVDVGATYYFNKNMSTFVDYKINLLDKNDFTKALGVSTDDIVAVGLVYQF
What are the official names of this protein?
Putative outer membrane porin protein NmpC.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein. Note=When expressed in mutant CS384.
Protein: AIM44_YEAS1
Sequence: MIIRAPIRTKTKSFRGDQMDFKFPSNESLPRGTLEEYHLNNHHLLNDVFAAENGVSRDEDGNSQILSDYTSTSNTNTNSGYSSNGYYSFANISDNTTSSPRIVINQNETARLTSSDSNKSDFFASHDFPGNDSLHYSSSSVVKNQLHSMEAIPEGNITGSISTAFQTIPTADNVSYDIAPSSASSLLPRKSTSKSAILPSTQEAKPMTKLNMEKDIKTIELNNSVVPKPKKKLNRVPTIRRVESSRFSNSRYSSSVSSKSSSSRCSLKRSKAIRCKGGLLYYFTSLGIKIKKKLRKLRLVLRRRLFSYNVQKVPSATNSKTTKSKANINNKSKKRGTNLVNKNSNSTPRQKKSQRYVSNLQRSISSKSLVPVLAPQKKTKPLTVDTKFKANHPQSEDSKVGSNTPRSPLVSYTPSLRRTNSSIRRAASILTASATMTPANNKNSFISVPDNVSHAVTRNSSMYSRSRLVRSKPSTALNAIARQPSIVVENKVIPLSMNRYSIKEEDEYVIDTSSMRELSPVNSVCSSDYDRESSESYSNYADAMETTEVDNKDRVECNNEIQNVNANNEETSNEESYNLMKHYLSTVIAQRIMLRVQIARIQNNKSNVVYMNKSAETNSTIYEDLADSLLTEYEADGSSSQIFDGVSVRADEEEEEDEDDEDDEEEEEENDDEEDEEDEEDDEDDEEEEEKRKEGEGRNLAKEVDELAELSPMRKQSDLSITLRSPFAMLNSAYSNSIISLPTGVVKRSLTLPVGMKI
What are the official names of this protein?
Altered inheritance of mitochondria protein 44.
What is the protein family that this protein belongs to?
Belongs to the AIM44 family.
What are the subcellular locations of this protein?
Bud neck.
Protein: THIE2_STRPN
Sequence: MNREALRLYLVTNRYQDSVESFLAKVETACRSGVTIVQLREKNLTTNQYYQLAKQVKEITDAYQVPLIIDDRLDVCLAVDAAGLHIGDDELPVSVARKVLGPEKILGVTAKTVKRALEAEKSGADYLGTGAIFPTTTKENAPITLISTLKTICQTVAIPVVAIGGLTSENIDQLMGTGIAGVAVVRDLMQAEDIEAKTQAFLKKLHNILS
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase 2, TP synthase 2, TPS 2, Thiamine-phosphate pyrophosphorylase 2, TMP pyrophosphorylase 2, TMP-PPase 2.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: HSE1_KLULA
Sequence: MSSHPKVKKAIERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLKQDANMILRTLSLVVALAENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVKREVLKVVHQLADSFKNDPSLKYMHDLESKIKISHPELISEPRVPKKKEMSKDREVEEEKELAEALRLSLLEFEKTGSRQQVQQPQQQQQQQQQQQQQQQQKLYPQNAEAQQQQAPTVIRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQQELAAERAKDEQVFAQKDNVDRLQNKLREAGNADITQDQEINDLYGSVSPIRPQISKMLGKYAQKKEDLVSLRQILANAEITYNQLLSRASNAYAYSAPPPAPMTGPAPTPGPQSPMSPTAQYTSPTNTQTQMNGIPNPPYSYPLPQQTQQIQQSEQTQQPLSQINSPQNYASSVGNTNYTGTNHIPQPLAPYPQYTGMSMQSIPPQQPQMPQHYNMSSNSNAQ
What is the function of this protein?
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
What are the official names of this protein?
Class E vacuolar protein-sorting machinery protein HSE1.
What is the protein family that this protein belongs to?
Belongs to the STAM family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: THP2_YEAST
Sequence: MTKEEGRTYFESLCEEEQSLQESQTHLLNILDILSVLADPRSSDDLLTESLKKLPDLHRELINSSIRLRYDKYQTREAQLLEDTKTGRDVAAGVQNPKSISEYYSTFEHLNRDTLRYINLLKRLSVDLAKQVEVSDPSVTVYEMDKWVPSEKLQGILEQYCAPDTDIRGVDAQIKNYLDQIKMARAKFGLENKYSLKERLSTLTKELNHWRKEWDDIEMLMFGDDAHSMKKMIQKIDSLKSEINAPSESYPVDKEGDIVLE
What is the function of this protein?
Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export.  The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription.  THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase.  It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
What are the official names of this protein?
THO complex subunit THP2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RAD13_SCHPO
Sequence: MGVSGLWDILEPVKRPVKLETLVNKRLAIDASIWIYQFLKAVRDKEGNQLKSSHVVGFFRRICKLLFFGIKPVFVFDGGAPSLKRQTIQKRQARRLDREENATVTANKLLALQMRHQAMLLEENNKKATALANASVQNERQMPSSMTLDNSEIKPVLNQRKNYLKPDPYQLPEMDVSFDKLGSSYDPRIMSQDELTQYVSSFTKIEDINLFDFSNIDFDSELFQSLPDTDKYSILSAARLRSRLRMGLSSEQLSEMFPNRMDFSRFQIERLKERNDLTQRLMDFTGMNEFGPSRVVSEKNREYILVKNEGAEGGWALGVISGSTNNEPIIIDDEATKLSSNLIDEDEDEAFYDVPLPSRSHSMNPRELVAAKLKEIKENSFSENQQSDEADYNVTDDLILQLATQQSLEENKKSKELFSLSASEFDKLNSEKKTFEILSTDIPAEDSMNSLLNDEENLKLEHVGDVSNDSLAFAEKKHPENGTSIFMDALPSASREKKTNDLIDPLPFQPMDWGKSIFFEKLKKPTETFMDSKTDIPSEAPDNSKLVEDTNLHTINATVNIESDLDAAKPGIENPIISPLLPVKDDEKDLDLRELNPLEPFENMKEQADDGTVTNPLNVSSDKAMSVYLLSSENAKDTGDIKSESIDAVLPTLETSSPSLSIPTDFQKEASPNKGAAALSSKVEPEVVEKLLDEEEEEMIIRMAEEEKEYDRFVSELNQRHETEEWNQEAFEKRLKELKNQKRSEKRDADEVTQVMIKECQELLRLFGLPYIVAPQEAEAQCSKLLELKLVDGIVTDDSDVFLFGGTRVYRNMFNQNKFVELYLMDDMKREFNVNQMDLIKLAHLLGSDYTMGLSRVGPVLALEILHEFPGDTGLFEFKKWFQRLSTGHASKNDVNTPVKKRINKLVGKIILPSEFPNPLVDEAYLHPAVDDSKQSFQWGIPDLDELRQFLMATVGWSKQRTNEVLLPVIQDMHKKQFVGTQSNLTQFFEGGNTNVYAPRVAYHFKSKRLENALSSFKNQISNQSPMSEEIQADADAFGESKGSDELQSRILRRKKMMASKNSSDSDSDSEDNFLASLTPKTNSSSISIENLPRKTKLSTSLLKKPSKRRRK
What is the function of this protein?
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.  Essential for the incision step of excision-repair (Probable).
What are the official names of this protein?
DNA repair protein rad13.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PPIL2_USTMA
Sequence: MGHGKSDRPFLSAAEHSGVYGAHSASSGKAGALEQASFHPVSYDCCAISFQPWSVPVCSPDCGIAFELTNLIPFLRKFSSVHPVTGKRFDLDNVVRLNLHKNQHGRFHDPVSFKEFGQHSHLVAIRQSGNVFLWDTVQRLNLKPKYMKDLVTDQAFTKSDIITVQDPEHPEHRNPSEMHHVKNALKLTQADKGIDSSQQINMGAIGSTHKLLSTLRETTQPDMHTASASSSTSASKHTTTAYSRNKASGSSTGMTAASFTSSSLTPRTAIERVILDDEEVMFSHIKSRPSSKAYVRLSTNFGALNLELHCGKAPKTCFNFLQLCKHGKYDDTLFHRNIPGFMIQGGDPTGTGRGGSSIWNSNFRDEFNEPGAFKHDTRGVLSMANKGKDTNASQFFITYRGVPHLDGKHTVFGRLVDGDKDATLTKMEQVPSEQGTDRPLKKIQIQDVLVTEDPFEQYQLRQKQSAKANDPTDPEYQRRMEKRKRRQNDRTTWLGTELPTNHPEAQQKQSETKIDNLLVGSWSVGKYLNSTGRPRTKTIQAHPARKEHDESAAKKTKTNTNAIAIANANANANAGFGDFSAW
What is the function of this protein?
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins.  May also function as a chaperone, playing a role in intracellular transport of proteins.  May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase-like 2, PPIase, Cyclophilin-60, Cyclophilin-like protein Cyp-60, RING-type E3 ubiquitin transferase isomerase-like 2, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RDRP_ROTS1
Sequence: MGKYNLILSEYLSFIYNSQSAVQIPIYYSSNSELENRCIEFHSKCLENSKNGLSLRKLFVEYNDVIENATLLSILSYSYDKYNAVERKLVKYAKGKPLEADLTVNELDYENNKITSELFPTAEEYTDSLMDPAILTSLSSNLNAVMFWLEKHENDVAEKLKVYKRRLDLFTIVASTINKYGVPRHNAKYRYEYDVMKDKPYYLVTWANSSIEMLMSVFSHDDYLIAKELIVLSYSNRSTLAKLVSSPMSILVALVDINGTFITNEELELEFSNKYLRAIVPDQTFDELNQMLDNMRKAGLVDIPKMIQDWLVDRSIEKFPLMAKIYSWSFHVGFRKQKMLDACAGTLKTEYTENVDDEMYREYTMLIRDEVVKMLEEPVKHDDHLLRDSELAGLLSMSSASNGESRQLKFGRKTIFSTKKNMHVMDDMANERYTPGIIPPVNVDKPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLIYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNTMVLYTDVSQWDSSQHNTQPFRKGIIMGLDILANMTNDAKVLQTLNLYKQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRISNKHSFATKIIRVDGDDNYAVLQFNTEVTKQMIQDVSNDVRETYARMNAKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAILYSNYIVNRLRGFETDREFILTKIMQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQKSGIADEIAASSTFKNYVTRLSEQLLFSKNNIVSRGIALTEKAKLNSYAPISLEKRRAQISALLTMLQKPVTFKSSKITINDILRDIKPFFTVSDAHLPIQYQKFMPTLPDNVQYIIQCIGSRTYQIEDDGSKSAISRLISKYSVYKPSIEELYKVISLHENEIQLYLISLGIPKIDADTYVGSKIYSQDKYRILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEVINYAIKNGSWISLFCNYPKSEMIKLWKKMWNITSLRSPYTNANFFQD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).
Protein: TMA46_YEAST
Sequence: MPPKKGKQAQAAGKKKDNVDKTFGMKNKNRSTKVQKYIKQVQSQSDPKKEEMRLKKLEEKKRREAEEAERRALFNPVADQRVRAGVDPKSMVCALFKLGNCNKGAKCKFSHDLNVGRRMEKKDLYQDTRSEKENDTMDNWDEEKLRKVILSKHGNPKTTTDKVCKYFIEAVENGKYGWFWICPNGGDKCMYRHSLPEGFVLKTNEQKRLERESLEKQPKITLEEFIETERGKLDKSKLTPITIANFAQWKKDHVIAKINAEKKLSSKRKPTGREIILKMSAENKSFETDNADMPDDVTQGSAWDLTEFTDALKKADHQDDGGIKDYGDGSNPTFDIKKANSATLA
What are the official names of this protein?
Translation machinery-associated protein 46, DRG family-regulatory protein 1.
What is the protein family that this protein belongs to?
Belongs to the ZC3H15/TMA46 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHAD_SALEP
Sequence: MQNITDSWFVQGMIKATSDAWLKGWDERNGGNLTLRLDEADIAPFATNFHEKPRYIALSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGVVKIDSDGAGYHILWGLTHDAVPTSELPAHFLSHCERIKATHGKDRVIMHCHATNLIALTYVLENNTALITRKLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAEVLVKIYSMGGMKQTITREELVALGKRFGVTPLASAVALY
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_HYPNA
Sequence: MLGLGPQQAAFEAALGALPDRLLDTPVGVAVSGGSDSLALLILAHRWAARRGRVLRALTVDHGLRPESRAEAEAVGRLCADMGIEHDILRLEGAAPRQSALRRGRHAALARTIADKSGHLLLTGHTADDQAETFLMRARQGSGWYGLAGMRPLSLSPVWPEGEGVFIARPLLGIRREALRAFLRDEGLGWADDPSNDNPAFERVRMRRLLCPEMSRNVPVLSLVDRFQTLRMIEDGAIWRWMTANVRAGEAGIHVASFAGHPPERAARALGMLLQIAAGREMPPRGESLRRLAEEIVSKGDFRGATLGGCRITARRTHICLKPECGPLPPGTAARLAATQAILSGNPNEIAASAGKESFLEDLVPIF
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSD_KLEP3
Sequence: MRFALTVTGPAYGTQQASSAWQFAQAVLQEGHELACVFFYREGVLNANQLTAPASDEFDLVRAWQSLHDEQGVALHICVAAALRRGVTDEREAQQLALASHNLQPGFTLSGLGALAEAALTCDRMVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C72B1_PINTA
Sequence: MADQISLLLVVFTAAVALLHLIYRWWNAQRGQKRTSNEKNQELHLPPGSTGWPLIGETYSYYRSMTSNRPRQFIDDREKRYDSDVFVSHLFGSQAVISSDPQFNKYVLQNEGRFFQAHYPKALKALIGDYGLLSVHGDLQRKLHGIAVNLLRFERLKFDFMEEIQNLVHSTLDRWVDKKEIALQNECHQMVLNLMAKQLLDLSPSKETNEICELFVDYTNAVIAIPIKIPGSTYAKGLKARELLIRKISNMIKERRDHPHIVHKDLLTKLLEEDSISDEIICDFILFLLFAGHETSSRAMTFAIKFLTTCPKALTQMKEEHDAILKAKGGHKKLEWDDYKSMKFTQCVINETLRLGNFGPGVFRETKEDTKVKDCLIPKGWVVFAFLTATHLDEKFHNEALTFNPWRWELDQDVSNNHLFSPFGGGARLCPGSHLARLELALFLHIFITRFRWEALADEHPSYFPLPYLAKGFPMRLYNRE
What is the function of this protein?
Multifunctional and multisubstrate cytochrome P450 that oxidizes the respective carbon 18 of abietadienol, abietadienal, levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol, and dehydroabietadienal.
What are the official names of this protein?
Abietadienol/abietadienal oxidase, PtAO, Cytochrome P450 720B1, Cytochrome P450 CYPA.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AIMP2_DROME
Sequence: MYELKTLLPQFDIKLPTCMYPLKNVSLAADSLASGSSTSASTSASTSSCKLEANRIDRTGRNAATCALDLDSLGRQIQRLLKDDTASVAARQEKVLKQLEELKAQLGQIRAGLGVCGKTFQHTTAFQNGGLKEVPLQDVVINGHPNFIPYALLALKNAWRNLYTIDVKTFTHSTMADIGPAAREFEANLAKVPVNPALPKISVTLIWKNCEHTEMISSPTMYVPIYGEVNIIRYLGRVGPAEYRYEGSPLCNEIDLVLDICYQLLRCNTHKTQVAMVRLLDKRLQKQQYFGGSQMSVADVGVYSSLIRMPAVTEKDLTPALVAWRKRAKLVVQI
What is the function of this protein?
Required for assembly and stability of the aminoacyl-tRNA synthase complex.
What are the official names of this protein?
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Probable multisynthase complex auxiliary component p38, aaRS-interacting multifunctional protein 2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: CBP4_ASPCL
Sequence: MSRVGTWLKMLVAGTVICVGGPAFVQSIRPTDEELFKRYNPDLQKRSLEEGDRRAREFDEYVTRLKQWSKSDKSIWFAAQEQQEQKRAELDAQQSRSKDEARIQREEMRKELLGEK
What is the function of this protein?
Essential for the assembly of ubiquinol-cytochrome c reductase.  It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity).
What are the official names of this protein?
Assembly factor cbp4, Cytochrome b mRNA-processing protein 4.
What is the protein family that this protein belongs to?
Belongs to the CBP4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: ZN788_HUMAN
Sequence: MRNMIPQDNENPPQQGEANQNDSVAFEDVAVNFTPDEWALLDPSQKNLYREVMQETLRNLASIEVLWKRDSLKVKVISMEKF
What are the official names of this protein?
Putative KRAB domain-containing protein ZNF788, Zinc finger family member 788, pseudogene.
Protein: EXO84_CRYNJ
Sequence: MASLRRPSTAIPRGPASVQFDRGARPPLPNDNKQKRMSKVGEKIKKRLSMRYGGNESFSVPPPLPGASDFLTADPYGGLDIETPGEDLAASPFGLYGASDLKESSIQSSQPLDTQEHLVDESIGRRGAADATLEEEWNLEELSNEKVDAQAYVKKVLTGADEEEKRRFVAALMREKQANKKELQRTVFKHYAEFVAISKEISTLENDMLELKELLGQWKDLPQLMGMEDTLAPTLDRNGNLERRRTQRKSVFDLQNLYRNQLTQLWSIVEGSQKYLPVVAGRHLVFELHGVVELNPATYKPKQNVSIFLLNDVLLIAGKRRNKGGSTTSVGDEKDRDRGRMVAERCWNLIELGIVDVKDGGELVNVIKVHRGKEHCVYRTQKSDDKRALINAFRQISREANEKKRKDSEKEQERRKTMWLGDKNGNGTGNSGHPLSTIGPSMADSKDLRWIDEYGDELTMAIAIRDWEESVKLVEKGQALSKSIESNSSAHSLLVSRLEQLVPSLVSQISHDLSSSNLRKSSSARLISLLVRLDLADHARDSFLESRRELMFKRVRSIKCDGDVSIYINELAVVIFTIIRHTSDWYMNAFKENNMASGFVTWAKQQIETFADLFRRQMDAPNISESTVNECLHVTATQNRKLLRDVGLDFTFLLSSLLQPSSNPSDYPHSVFTSV
What is the function of this protein?
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis.  Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis.  Also involved in assembly of the spliceosome (By similarity).
What are the official names of this protein?
Exocyst complex component EXO84.
What is the protein family that this protein belongs to?
Belongs to the EXO84 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Note=Cell periphery. The polarization of EXO84 requires actin cables (By similarity).