PharMolix/UniProtQA huggingface dataset:
Protein: S28A3_HUMAN
Sequence: MELRSTAAPRAEGYSNVGFQNEENFLENENTSGNNSIRSRAVQSREHTNTKQDEEQVTVEQDSPRNREHMEDDDEEMQQKGCLERRYDTVCGFCRKHKTTLRHIIWGILLAGYLVMVISACVLNFHRALPLFVITVAAIFFVVWDHLMAKYEHRIDEMLSPGRRLLNSHWFWLKWVIWSSLVLAVIFWLAFDTAKLGQQQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYKDHFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKSELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHLRKEGGPKFVNGVQQYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAGILSSTPVDINCHHVLENAFNSTFPGNTTKVIACCQSLLSSTVAKGPGEVIPGGNHSLYSLKGCCTLLNPSTFNCNGISNTF
What is the function of this protein?
Sodium-dependent, pyrimidine- and purine-selective (PubMed:11032837, PubMed:15861042, PubMed:16446384, PubMed:17140564, PubMed:21998139).  Involved in the homeostasis of endogenous nucleosides (PubMed:11032837, PubMed:15861042).  Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) (PubMed:11032837).  Employs a 2:1 sodium/nucleoside ratio (PubMed:11032837).  Transports uridine (PubMed:21795683).  Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (PubMed:11032837, PubMed:17140564).
What are the official names of this protein?
Solute carrier family 28 member 3, Concentrative Na(+)-nucleoside cotransporter 3, CNT 3, hCNT3.
What is the protein family that this protein belongs to?
Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RDH8_HUMAN
Sequence: MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
What is the function of this protein?
Retinol dehydrogenase with a clear preference for NADP.  Converts all-trans-retinal to all-trans-retinol.  May play a role in the regeneration of visual pigment at high light intensity (By similarity).
What are the official names of this protein?
Retinol dehydrogenase 8, Photoreceptor outer segment all-trans retinol dehydrogenase, Short chain dehydrogenase/reductase family 28C member 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: MTLD_MYCMS
Sequence: MNLIHFGAGNIGCGFIAPILSSIVDHIYFVDNNIDIVNKINTQKLIKIHTSDSKKISITNISAWLLTDFINYKKTWNEVSLLTISIGIKNLKHIIYYVNQLIDYKIKNNQKLIIMCCENGIRVSSLFKSYFSNLNNNIYFVDVLVDRIVSNKNILNDYLECEDYYLWIVDKTQLPSDFKQVPNLTYTTSFDIQITKKIYMLNALHCSLAWFVFKNFSFNKYLYVYQALKNDKVVEFVNNYLNEVILVLNHKYNINLDELNNYKNQIIKRLNSNFIKDDLKRLARNTELKLSKNERILTILDYAKDNNLKHDILLLSYQNGLEYLKNNK
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: DNJB9_MOUSE
Sequence: MATPQSVFVFAICILMITELILASKSYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEAYETLSDANSRKEYDTIGHSAFTNGKGQRGNGSPFEQSFNFNFDDLFKDFNFFGQNQNTRSKKHFENHFHTRQDGSSRQRHHFQEFSFGGGLFDDMFEDMEKMFSFSGFDTTNRHTVQTENRFHGSSKHCRTVTQRRGNMVTTYTDCSGQ
What is the function of this protein?
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity).  J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:11836248).  In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity).  Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:22267725).  Required for survival of B-cell progenitors and normal antibody production (PubMed:25222125).
What are the official names of this protein?
DnaJ homolog subfamily B member 9, Endoplasmic reticulum DNA J domain-containing protein 4, ER-resident protein ERdj4, ERdj4, mDj7.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: CCD77_MOUSE
Sequence: MNFTPTRTPICRKISFASKRGAGSGFGDTNRWKKMADSMESTPLPSVEDRLAVLCPSQELLEYYQKKMANCESENEDLLKKLELYREACEEQHKLEWNLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGPDAGEVTYFHKEPPHRVSILQKTLQAAVACEPSASKADPGVSKRQVRIKDKEGISERHQRDTEMLLLQVEALQAQLGEQTKLSREQVEGLMEDRRIRVEEIQVQHQRNQEKIMELTKSLHHTQELLYESTKDFLQLKFENQNKEKVWMLEKDHLMSKITQYRAQCKKKEDKLGKVVPILHESHHTQNEYIKSLKDKLIQEKKLSNMYQEQCISLEEELARIREEEGVRREIFKDRSNKMGKRLQIMTKRYQALEHRRALEVEGFKTDIKSLRQKLRDLEQMLYKATMNNTHGDQDLAMLCEVRDSNRRAHKIQGELKNLKSKVFGLENALRLC
What are the official names of this protein?
Coiled-coil domain-containing protein 77.
Protein: RS10_STRPN
Sequence: MANKKIRIRLKAYEHRTLDTAAAKIVESATRTGAQVAGPIPLPTERSLYTIIRATHKYKDSREQFEMRTHKRLIDIVNPTQKTVDALMKLDLPSGVNVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: DNAA_BORPE
Sequence: MKEFWQTCVSRLEQELPPQQISAWIRPLVPLAYDEAQAVLRVAAPNRFKLDWVRKNFSHQIEALAAEWYQRPVQVTFELPGTSSAPRIPMAVPRPVAVSVPAVVAAVQQASEPAPPAPASADAANIVYERSRLNTDLTFENFVTGKANQLARAAALQVAENPGTSYNPLFLYGGVGLGKTHLIHAIGNAMVAAGTGVRVRYVHADQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKNRTQEEFFYAFEAMVAQRKQIIITSDTYPKELSGIDSRLISRFDSGLTVAIEPPELEMRVAILLRKAESEGVPMPEEVAFFIAKHLRSNVRELEGALRKVLAYARFHGRDVLTVDVCKEALKDLLSVSNGQITVENIQKTVADFYKIKVADMYSKRRPANIALPRQVAMYLAKELTQKSLPEIGDLFGGRDHTTVLHAVRKISDARAKQAELNHTLHVLEQTLKG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASCC1_HUMAN
Sequence: MEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNTSNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEVLAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNLYTAEGKYIFKERESFDGRNILKSFALLPRLEYNDAISAHCNLCLPGSSDSPASASQVAGITGVSDAYSQSLPGKS
What is the function of this protein?
Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253).  Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).  In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin.  May also play a role in the development of neuromuscular junction.
What are the official names of this protein?
Activating signal cointegrator 1 complex subunit 1, ASC-1 complex subunit p50, Trip4 complex subunit p50.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage.
Protein: EX7L_BACCR
Sequence: MEKQYLTVTALTRYIKTKIEYDPHLQSVWLKGEISNFKNHSRGHMYFTLKDENARIAAVMFAGHNRNIKFKPENGMKVLVKGKISVYEASGSYQIYIQDMQPDGVGNLHLAYEQLKVRLEEEGLFSQVYKKAIPPYAKTIGVITSPTGAAIRDIITTIKRRYPIGNVIVFPVLVQGESAAPSIVQAIRTANEMGEIDVLIVGRGGGSIEELWAFNEEMVARAIFKSEIPIISAVGHETDFTIADFVADLRAPTPTAAAELAAPNIIELQEKVLQRTLRLQRAMRELVHKKEEKLQVLQKSYAFRYPRQVYEQKEEQLDRALEQLVLAKERYIDKKVNQLKQLSFYLEKHHPSQKIMQTKVAVETLQKQLQREMQTLLQTKEFAFVRAAQKLEALSPLKVMMRGYGLVYDEEKQVLKSVKDVSLGDAVSVQLQDGILDCSVSGIEERELNNGK
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_TOLAT
Sequence: MLKRDMNIADYDPELWASIVEETQRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEFVDKTETLAIERAKALFGAVYANVQPHSGSQANAAVYMALLKPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDASGKIDYVELERLALEHKPKMVLGGFSAYSGVVDWAKMREIADKVGAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTSTTHKTLAGPRGGLILSAVNDEELHKKLNSAVFPGTQGGPLMHVIAGKAVAFKEAMEPEFKAYQQQVVKNSKAMVEVFLARGYKIVSGGTENHLFLVDFTDRELTGKEADAALGLANITVNKNSVPNDPRSPFVTSGIRIGSPSITRRGFKEAEAKELAGWICDVLDNRTDEAVIAATRAKVLDICKRLPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSM_BACSU
Sequence: MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSVKDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKERINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTAPEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGKPGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACFAAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI
What are the official names of this protein?
Probable cysteine synthase, CSase, O-acetylserine (thiol)-lyase, OAS-TL, O-acetylserine sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: CAPSD_RRSVT
Sequence: MSNLPKPASHFEPEKNVDDKGNVTGSAPPVSKDTPTQQASVSLPNQEEPTQQTLVTTELPTKPDYNDLLLKASDERLLLVKEAKPQTLRFYASPTGLTASGFSIVTSPTSSYEQHAIDIFPYNCPVDKIVPAFTLEQIKITNDVLSSAQQSYLSRIPHDTSLVKLNEIEVVTGGSRDLFSLGTGYVMVVPNAEFFEGANLKFVYGVPMADIIFSKLTSQSAADYAFLDRSRIASGFIMFALHFALRTNVNLVVTKDNSARFASELSYSRPMSFVQGKKIVLPVQPHVCFAEGNSLMRYLDTALEGKYTQGVTYKYGRERIITETKEGGPITEITYLNIDNVTAQALGITAHVIGIDRYREDNVKRALLAYSLSGSTVDLMQSDESERMFGRMLSPQQELSYLLVGAALSQDVYKTILRANLDAFMMFGTVMPSLSDSLAKIPADAGNQQIISLIRERQSVSGFENAMEYLAMQVTPPLIWPCVISREVNVTGLSLLIMLLEYILFFIFYPSLAKKCGAGLCNNFYKLVFALSNSEWSQFVTRVGYDGTLGNSIPITDEDYWSNARRPALFTTDLSQFRLLGLIQRLIAPIGEHREHVKAQAAEFPRLKARTEYWNPYPNPGAQHVEQTIFKARLLQAFDETLTLVKDLNQTGQLVSKTLMAGVAKVFNTCKIKLRYHGVGFGRDIGMPLAYLRDRKINFYHDYDGRLDTPFPNQMMLVSASQSPHDHKIPIELRRKGQIVLETGVVWTLVLGLQFPSHQFDEDMTNDPICKFRAPSPGEELGKDDTIIAMCANACVPFSIAAGIISESYADGGMKEIKELLSGSLSSTEFRNLISCIQTAMQGSGFNVGRNRDVFRQNETVDLRFIEPKVRYVENELTIIAPTPQDPPIIRGDLQLIPEGLMPRFRLGLTAIADSSSEYSRLRKGLYLARCEVDVEAPNNALPLDLRDYVEVEYSHDLFQVRRIQTKQALGIFYQGEFYYRPALVPKMLIVVNTSEEMEPSYQEFFMQCLEERRIVIKLPKMYFLSRIVCTHSIQRPDERDAVLGLLAVRNDQIPLVTFYDTEQVDPTIQFDGLASGSKSKFIWPISSIDQNVVVRALGASGSTAPIGFAAPTDSMCDSGSIDDVGNLTTGAGVLKDPRVISLTNGVINYTERANLTGRVLYRYRPAYALDSY
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a pseudo T=2 symmetry, about 70 nm in diameter, and consisting of 120 capsid proteins.  The capsid encapsulates the genomic RNA (By similarity).
What are the official names of this protein?
Major inner capsid protein VP3, Major core capsid protein VP3.
What are the subcellular locations of this protein?
Virion.
Protein: PLSX_STAAS
Sequence: MVKLAIDMMGGDNAPDIVLEAVQKAVEDFKDLEIILFGDEKKYNLNHERIEFRHCSEKIEMEDEPVRAIKRKKDSSMVKMAEAVKSGEADGCVSAGNTGALMSAGLFIVGRIKGVARPALVVTLPTIDGKGFVFLDVGANADAKPEHLLQYAQLGDIYAQKIRGIDNPKISLLNIGTEPAKGNSLTKKSYELLNQDHSLNFVGNIEAKTLMDGDTDVVVTDGYTGNMVLKNLEGTAKSIGKMLKDTIMSSTKNKLAGAILKKDLAEFAKKMDYSEYGGSVLLGLEGTVVKAHGSSNAKAFYSAIRQAKIAGEQNIVQTMKETVGESNE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: A1_BPSP
Sequence: MAKLNQVTLSKIGKNGDQTLTLTPRGVNPTNGVASLSEAGAVPALEKRVTVSVAQPSRNRKNFKVQIKLQNPTACTRDACDPSVTRSAFADVTLSFTSYSTDEERALIRTELAALLADPLIVDAIDNLNPAYWAALLVASSGGGDNPSDPDVPVVPDVKPPDGTGRYKCPFACYRLGSIYEVGKEGSPDIYERGDEVSVTFDYALEDFLGNTNWRNWDQRLSDYDIANRRRCRGNGYIDLDATAMQSDDFVLSGRYGVRKVKFPGAFGSIKYLLNIQGDAWLDLSEVTAYRSYGMVIGFWTDSKSPQLPTDFTQFNSANCPVQTVIIIPSL
What is the function of this protein?
Minor capsid protein.
What are the official names of this protein?
Minor capsid protein A1.
What are the subcellular locations of this protein?
Virion. Note=Present in 3-10 copies per virion. The readthrough extensions are probably located on the exterior of the capsid.
Protein: ARGP_YERPB
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENLFGQPLLVRTVPPRPTEQGQKLLALLHQVELLEEEWLGNDNGVDTPLLLSLAVNADSLATWLLPALKPVLADLPIRLNLQVEDETRTQERLRRGEVVGAVSIQPQPLPSCLVDQLGALDYLFVASKAFAERYFPNGVTRSALLKAPAVAFDHLDDMHQAFLQQNFDLSPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELASGELIDLTPGLLQRRMLFWHRFAPESRTMRKVTDALLSYGRQVLRQDSFIGQ
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: COAD_STAA3
Sequence: MEHTIAVIPGSFDPITYGHLDIIERSTDRFDEIHVCVLKNSKKEGTFSLEERMDLIEQSVKHLPNVKVHQFSGLLVDYCEQVGAKTIIRGLRAVSDFEYELRLTSMNKKLNNEIETLYMMSSTNYSFISSSIVKEVAAYRADISEFVPPYVEKALKKKFK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_I01A3
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEKSHPGIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKGEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRKQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTGRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWVPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: RFFL_MOUSE
Sequence: MSQPSLWKDSHYFIMWASCCNWFCLDGQPEEAPPPQGARTQAYSNPGYSSFPSPTGSEPSCKACGVHFASTTRKQTCLDCKKNFCMTCSSQEGNGPRLCLLCLRFRATAFQREELMKMKVKDLRDYLSLHDISTEMCREKEELVFLVLGQQPVISEADRTRVPHLPQAFPEQQAFLTQPQTSTVPPTSPGLPSSPAQVTSVPLAQDQETQQAVGHVSQDHEEPIFPESTARVPTEDETQSVDSEDSFVPGRRASLSDLTHLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKDQKGLQHLVSGNEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICRQYVIRAVHVFRS
What is the function of this protein?
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins.  Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex.  Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors.  Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.  Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation.  Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN.  May also play a role in endocytic recycling.
What are the official names of this protein?
E3 ubiquitin-protein ligase rififylin, RING finger and FYVE-like domain-containing protein 1, Fring, RING-type E3 ubiquitin transferase rififylin.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate-binding and control subcellular localization.
Protein: KHSE_CHLTE
Sequence: MKTVTGFASATVGNVACGFDVLGFAITEPGDEVVLALHDERRSDCPVSITSIVGDGGALPLDPKKNTSSFVVLKFLEYIRTTKGISFDGHIDLVLKKNLPLSSGMGSSAASAAAALIAANELFGSPCTKMELVHFAIEGERVACGSAHADNAAPAMLGNFILIRSYNPLDLITIKPPKNLFGTLVHPHTELKTSFARSVLPKSIPLSTATQQWGNVGALIAGLLMEDYDLIGRALVDVVAEPKRAPLIPGFNEVKQAALDAGALGCSIAGSGPSVFAFSSSRQTAEAVGSAMQSAFLHSRAALQSDMWVSPICSQGARIISTTS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTOA_DICDI
Sequence: MKLIAFIAFLLILITIINAQGSIGSSSQSLSSEVDSSDISSSGSNSTASSEGSVSSSSNSGSQSTSNSGSEASGSSNSGSQSTSNSGSEASGSSNSGSQSSTDSSNSGSQGSTGSSNSGSQSSTDSSNSGSQSSTDSSNSGSQGSTGSSNSGSESSGSSNSGSEGSTGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSGSSNSGSESSSDSGSSSDGKTTCISFHDTLSINTVDDDEIECTGKGETRCISDNNYKCATKQRHGSIECSVNGYIRCTGSNIKCKIGNTECSIRNSRLDITEKPIFTRGPRHH
What is the function of this protein?
May have dual functions, one in vegetative cells at starvation involving cell-type choice and a later function involving progression to the tipped mound stage.  Involved in vesicle fusion in endo- and exocytosis.  Involved in L. pneumophila intracellular growth.
What are the official names of this protein?
Protein rtoA, Ratio-A.
What are the subcellular locations of this protein?
Cytoplasm. Note=Mostly found in the cytosol but also found associated with both small organelles or vesicles.
Protein: LIPB_AROAE
Sequence: MIAGGELAALPPQAPQPAGTPALVVRRLGCVDYEPTWHAMRAFTDARSADTPDEIWLLEHPPVYTLGQAGQPEHLLRDVGIPLVKIDRGGQITYHGPGQLVAYLLIDLHRRGLKVRELVTLMEQAVIDCLAGYGVGAERKAGAPGVYVDGAKIGALGLRVRNGRSYHGLALNVDVDLAPFSSINPCGYEGLRTVRMKDFGIADDVASVGEHLLTALQRLLPPVYPAGRPPA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: V2_BCTVC
Sequence: MGPFRVDQFPDNYPAFLAVSTSCFLRYNRWCILGIHQEIGSLTLEEGEVFRQFQKEVKKLLRCKVNFHRKCSLYEEIYKKYVYNVPEKKGESSKCVAEEEED
What is the function of this protein?
May be involved in the regulation of ssDNA versus dsDNA levels.
What are the official names of this protein?
Protein V2, 12.1 kDa protein.
Protein: ERA_STRP8
Sequence: MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVINKIDKVHPDQLLEQIDDFRSQMDFKEVVPISALEGNNVPTLIKLLTDNLEEGFQYFPEDQITDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEETDKVHIRATIMVERDSQKGIIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNEKEY
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: PURQ_RHOJR
Sequence: MSARVGVITFPGTLDDVDAARAVTLAGGEAVSLWHGDADLKGVDAVIVPGGFSYGDYLRCGAIARFAPVMGKVVQAAQGGMPVLGICNGFQVLCEAGLLPGALTRNEGLHFICRDEWLKVEATSTAWTSRYESGAEILVPLKSGEGRYQASENVLDELEGEGRVVFRYVGDNPNGSQRGIAGISSANGRVVGLMPHPEHATEALTGPSDDGLGMFYSVLDSVISA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_CLOB8
Sequence: MRIKKSDFITSAVKKNQYPIDNRVEVAFVGRSNVGKSSLINSLTNRKKLAKVSQTPGKTRLVNFFLINDDFYLVDLPGYGYAKVSKAEKDSWGKTVEMYLTGREQLKRVVLLVDSRHKPTGDDIIMHEWIKHFGYDVIVVATKSDKLTRNELKKNEKVIKETLKLNSDDKLYFFSSLNKDGKDELIDNLFLEFATDLD
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.