PharMolix/UniProtQA huggingface dataset:
Protein: HMDH_AGRIP
Sequence: MKVWGAHGEFCARHQWEVIVATLALLACAASVERNGPGNRSEHCAGWARACPGLEAEYQAADAVIMTFVRCAALLYAYYQISNLHKIASKYLLIIAGVFSTFASFIFTSAVASLFWSELASIKDAPFLFLLVADVARGARMAKAGWSAGEDQGKRVGRALALLGPTATLDTLLAVLLVGVGALSGVPRLEHMCTFACLALLVDYLVFVTFYPACLSLVADFASGRKEMSPDSPFSEADLKPNPVVQRVKMIMAAGLLCVHLTSRWPWSSDNGIIEGPTDTLTPTSNDNILLHSYVKWFSVSADYIVIATLLCALIIKFVFFEEQRNWVIDMNDMTVKEVVQEQARSKPKFSVGDDSNSEVSTQTEGVLEDEWPTLSPSSSAAKLNSKKRPMAECLEIYRSEGACVSLSDEEVVMLVEQSHIPLHRLEAVLGDPLRGVRLRRKVVGARFQTELAIKQLPYLNYDYSKVLNACCENVIGYVGVPVGYAGPLVVDGKPYMIPMATTEGALVASTNRGAKAIGIRGVTSVVEDVGMTRAPAIKLPNVVRAHECRQWIDNKDNYAVIKEAFDSTSRFARLQEIHIGVDGATLYLRFRATTGDAMGMNMVSKGAENALKLLKNYFPDMEVISLSGNYCSDKKAAAINWVKGRGKRVVCETTITSDSLRTIFKTDAKTLARCNKIKNLSGSALAGSIGGNNAHAANMVTAIYIATGQDPAQNVTSSNCSTNMEVCGENGEDLYVTCTMPSLEVGTVGGGTILTGQGACLDILGVKGAGARPAENSARLASLICATVLAGELSLMAALVNSDLVKSHMRHNRSTVNVQVQAENITLKVPTL
What is the function of this protein?
Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PDXJ_HELP2
Sequence: MRFGLNIDHIVTLREIRKTYEPEILEALFIAKNTHKVDLITIHLREDKRHIQNEDVLRLLEISPLPINIECSINATITDFLCSLKNKPSKVTIVPENRNEVTTEGGLDCSLKGLEEVIRAYHNKGIEVSLFIDPLKDSLHFAREHQVKQVEFHTGVYANLHNALYSNANNQIHAISALKDKSPKELKEELHNAFLQLRRMSKEAFFMGITACAGHGLNYTNVKELLKIPSLRELNIGHSVVSKAVLVGLEKAILEMAQLIKR
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_SACEN
Sequence: MFRTMLKSKIHRATVTQADLHYVGSVTVDADLMDAADLLEGEQVAIVDVTNGARLETYVITGERGSGVIGINGAAAHLIEPGDLVILISYGVMDELEARSVRPKVIFVDADNRIVERGQDPGHAPAGSGLAGTAASVTSAITEAAAETDDAAKLDALLQQPEH
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_SALDC
Sequence: MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVTLDFKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVTDVLERLVRDIPPPQGDPDGPLQALIIDSWFDNYLGVVSLVRIKNGTMRKGDKIKVMSTGQTYNADRLGIFTPKQVDRTELKCGEVGWLVCAIKDILGAPVGDTLTSARNPAEKALPGFKKVKPQVYAGLFPVSSDDYESFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTAKETIYVDSPSKLPPLNNIYELREPIAECHMLLPQAYLGNVITLCIEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINNERVDALALITHRDNSQSRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS17_PSEA6
Sequence: MTEQSSRTVQGRVVSNKMDKTITVAVERKVKSPIYGKFIKRTTKLHAHDETNQCNTGDVVTVRECRPMSKSKNWMLVDIVTKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: TBP_PYRAE
Sequence: MSSKGPSYRIENIVATVNLGVELDLEQLAERLTMAEYNPDQFPGLILRLTKPRISALIFRTGKMVCTGAKNEEDLKNAVRALVKLLKDHGADVPFDPEVQIQNIVASGNLHAEVDLEQAVLMLENAMYEPEQFPGLIYRMSSPRVVILIFGSGKIVCTGAKSEKDVATAVQKLYNQLKELGVLYVEEGGEELEEFEEEL
What is the function of this protein?
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
What are the official names of this protein?
TATA-box-binding protein, Box A-binding protein, BAP, TATA sequence-binding protein, TBP, TATA-box factor.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
Protein: PRMA_XANOM
Sequence: MPFLELTLSCSEVTLPRFQNALDDVGAMAVTMLDANADTSNERALLEPGVGEMPLWDRLTMTALFDGGSDALVVLAALEAFDPGLDWSQVGFRMVEDSDWIRAWIDLFKSMQFGARTFIVPWNQDVPEAANAPDAAVVRLDPGLAFGSGTHQTTALCLRWLDSLAVSGELQGRSVLDFGCGSGILAIAALKLGASHAVGVDYDPQALLATADNAHRNALEAQLAVYMPQDEPVQTYQVVVANILASALSTLADTLAARVVPGGRIALSGILHGQEDELLERYAPWFEQLRCERDDEWMRIEGVRRAASGTQNG
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILF3A_XENLA
Sequence: MRPMRIFLNDDRHVMAKHSVVYPTQEELEAVQNMVSHTERALKAVSDWIDQQEKDCSGEQEQPMAEETETTEEGKDSEMKTGENPTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCRDKPTISLLKRVADNLVLQFETVSEDKYEVIQNIREALIVVKSTKEPPLTLNIRLTSPLVREEMEKLSAGETLTVSDPPDVLDRHKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWEPLRGWPLELLCEKAIGTANRPMGAGEALRRVLECLSSGILMPDGSGLYDPCEKDASDALEHLERQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKTKVETPVIDYTVQIPPSTTYAMPPLKRPIEEDGDDKSPSKKKKKIQKKDEKSEPPQVMNALMRLNQLKPGLQYKLISQTGPVHAPVFTMSVEVDDKTFEASGPSKKTAKLHVAVKVLQDMGLPTGMEEKEEGTDESEQKPVVQTPAQPDDSAEVDSAALDQAESAKQQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGVKFQGSGSNKKVAKAYAALSALEKLFPDYTMYTEAPKKKRPPMMPRGGPKFAGKHNQGFGMMYSEVPPPQAMRGRGRGGMNRGRGRGRGGFGGGYMNSGGYGGGYGGNYNYQTSATAGYSQFYSNGGASGNAGGGGAGTGGYSSYYQGDSYSAPTPPKPFVNKKPPPPQQQQQQQPPPQHASNPPKPSYNQGYQGHQGGQQQQQQQQQQQTYNQNQYSNYGPPQKQKGGYNQGAQGAGSGGSYNYSNSYTGGTAPLGTAVERVQEGEAAALTQRQALVTTQAHTPAMVEPAVLRRTKVTRSLITIKVPPDRTTVALQIITSSLREELGVTAGIQNTT
What is the function of this protein?
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs.  Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons (By similarity).  Plays thereby a role in the back-splicing of a subset of circRNAs (By similarity).  As a consequence, participates in a wide range of transcriptional and post-transcriptional processes (By similarity).  Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity).  Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (By similarity).  Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs.  In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (By similarity).  Has a cytoplasmic role early in development as part of a ribonucleoprotein (mRNP) complex which may regulate mRNA transport and/or translation.  Following nuclear localization at the mid-blastula transition, acts as a transcription factor and binds the 5'-CCAAT-3' promoter sequence to regulate transcription of the gata2 gene as a subunit of the CCAAT box transcription factor (CBTF).  Its role as an mRNP component negatively regulates its activity as a transcription factor by precluding its nuclear localization (PubMed:10899122, PubMed:15452137, PubMed:18636753, PubMed:19665599, PubMed:7922339, PubMed:9710639).
What are the official names of this protein?
Interleukin enhancer-binding factor 3-A, CCAAT box transcription factor subunit, Double-stranded RNA-binding protein 4F.1, DsRNA-binding protein 4F.1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Cytoplasmic in fertilized eggs, then translocates to the nucleus prior to gastrulation. RNA-binding is required for cytoplasmic retention during early development, and nuclear translocation at the mid-blastula transition (MBT) is probably coupled to the degradation of maternal mRNA that occurs at that stage.
Protein: NEUV_PELLE
Sequence: CYIQNCPRGGKRSYPDTEVRQCIPCGPGNRGNCFGPNICCGEDLGCYIGTPETLRCVEENYLPSPCEAGGKPCGAGGRCAAPGVCCNDQSCTMDSSCLDEDSERQRVSPDQNMTQMNGSASDLLLRLMHMANRQQQQTKHY
What is the function of this protein?
Vasotocin is an antidiuretic hormone.
What are the official names of this protein?
Vasotocin-neurophysin VT, VT.
What is the protein family that this protein belongs to?
Belongs to the vasopressin/oxytocin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURA1_STAES
Sequence: MDKIVINGGNRLTGEVNVEGAKNAVLPVLTASLLASEGHSKLVNVPELSDVETINNVLSTLNANVEYDKDKNAVKVDATKTLNEEAPYEYVSKMRASILVMGPLLARLGHAIVALPGGCAIGTRPIEQHIKGFEALGADIHLENGNIYANAKDGLKGAHIHLDFPSVGATQNIIMAASLASGKSIIENVAKEPEIVDLANYINEMGGKITGAGTDTITIHGVEKLYGVEHAIIPDRIEAGTLLIAGAITRGDIFVRGAIKEHMASLIYKLEEMGVDLEYYEEGIRVTANGDLNPVDVKTLPHPGFPTDMQSQMMALLLTANGHKVITETVFENRFMHVAEFRRMNANISVEGRSAKIEGKSHLQGAQVKATDLRAAAALILAGLVAEGTTQVTELKHLDRGYVNLHGKLKSLGANIERVNR
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, Enoylpyruvate transferase 1, UDP-N-acetylglucosamine enolpyruvyl transferase 1, EPT 1.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_ALTMD
Sequence: MTTNIHDQRILILDFGSQYTQLIARRVREIGVYCELWAWDVTEEQIREFNPQGIILSGGPESVTEEGSPRAPDYVFEAGVPVLGVCYGMQTMAHQLGGGVLGSDKREFGYAQVEVIKPSPLLDKIEDAIGDNGAALLDVWMSHGDKVAAIPEGFETIAQTASCPHAAMYNEEKQFYGVQFHPEVTHTRQGMRLLTQFVMDICKCEKLWTAGAIIEDAIERIKEKVGDERVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEADQVMEMFGDHFGLNIIRVDAEGRFLDRLKGIEDPELKRKAIGNEFVRVFDEEASKLENAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPEDMELGLVEPLRELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEIKKEYCDLLRRADAIFIEELYAADLYQKVSQAFTVFLPVRSVGVMGDARKYDWVVSLRAVETIDFMTAHWAHLPYDFLGKVSNRIINEIDGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PSD_VIBPA
Sequence: MDKIKVGLQYWIPQHGLTRLVGKLASAKAGSLTTAVIRWFIKQYNVNMDEAKHSDPKHFKTFNEFFVRELKEGARPITEGDEIITHPADACVSQFGPIEDGQLIQAKGHNYSAQELLGGDEKLAEEFKDGSFATLYLSPRDYHRVHMPCDGTLRQMIYVPGDLFSVNPLTAENVPNLFARNERVVCIFDTEFGPMAQVLVGATIVGSIEQVWAGTITPPRGNTVYKWDYPAEGDKAVILKKGEEMGRFKLGSTVINLFAKDAIEFDVSMENGQPTVMGTPYALKK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS2_DESVH
Sequence: MAYVSMKQMLETGVHFGHQTRRWNPKMRPFIFGARNGIHIIDLQQTVKMFRVAHDKVVDTVANGGRVMFIGTKRQAQEAVATEAGRAGQFYVTNRWMGGTLTNFFTIQKSIDRLKKLEAMFADGTVNRYQKKEILRLQREMDKLLATLGGIKDMDKLPQLAFVIDPHREDIAIKECRKLGIPIVAVTDTNCDPDLIDFVIPGNDDAIRAIKLFVAAIADACLEGDALRKERKGQDAEEELKKASEPKAAEAAAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: FTN_STAA3
Sequence: MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEESMFETHINYLTRIGDDSNALYLYEKELGARTFDEE
What is the function of this protein?
Iron-storage protein.
What are the official names of this protein?
Bacterial non-heme ferritin.
What is the protein family that this protein belongs to?
Belongs to the ferritin family. Prokaryotic subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_HAMD5
Sequence: MDSINKCESHTPMMQQYLRLKSEHPEVFLFYRMGDFYELFYDDAKRASRLLDISLTQRGQSAGTPIPMAGVPYHVIDNYLAKLVQLGESAAICEQVGDPSTSKGPVERKVVRIVTPGTISDEALLQEKQDNLLAAVWQDKQGLGYATLDISSGRFRAMEPKDLEALKTELQRTHPSELLYPETFELIDLIESRQGLRRRPLWEFELETARQQLNLQFGTQDLTGFGVEQAHLALRAAGCLLQYVKDTQRTSLPHIRELILQHEEDNVTIDAASRRNLELTENLSGGTENTLASILDCTVTSMGSRMLKRWLHMPITDMSTLHHRQEAIRVLQHVASDLKPLLRKVGDLERILARLALRTARPRDLARMRLAFEQLPEIHDVLNTCKSQHLKKLLSEIGQFDALLDLLRRAIVDVPPVLIRDGGVIATGYNEELDKWRALSDGAHDYLNELEIRERHELKLDTLKVGFNAIHGYYIQVSRAQSHLIPAHYARRQTLKNVERYIIPELKEYEDKVLTSKGKALSIEKDLYEEIFDLLLPHIASLQTSSTALAELDVLSNLAERADTLNYVCPVLTEKSVIEITGGRHPVVEQVSKQPFIANPISLSPERRMLIITGPNMGGKSTYMRQTALIVLLAHIGSFVPADKAIIGSVDRIFTRIGAADDLASGRSTFMVEMTETANILHNATEKSLVLMDEIGRGTSTYDGLSLAWACAENLSIHIKSMTLFATHYFELTSLPEKINGIVNVHLQALEQGDEIAFMHSVHEGAASKSYGLAVAALAGVPKKVIDRARQRLEELEFTLEENGHTKPSLPASKPVFEKESTDHPVIRKLKTLKPDTMTPYDALQWIYYLQKMF
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RSMH_SHIDS
Sequence: MMENYKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAKTIDDPRFSIIHGPFSALGEYVAERDLIGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTCGQSAAEWLQTAEEADIAWVLKTYGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLNVLAPGGRLSIISFHSLEDRIVKRFMRENSRGPQVPAGLPMTEEQLKKLGGRQLRALGKLMPGEEEVAENPRARSSVLRIAERTNV
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBP3_AJECN
Sequence: MAKRSRNMESNSERSSRPKKKSKGDAKPEQPPYVQSAELDAVPQSEIDDFLKSNTIQISDPSIKETLRPITAFSYLPSDSNQLYGPLEHFSKPTPIQSVTWPYLFAGRDVIGVAETGSGKTLAFGVPCIRKVLEINASHSSFRISAVIITPTRELAMQIHDQLVKFTPNGVGLACIYGGASKDDQRRALKKASVIVATPGRLKDFHSDESLNLKKVKYLVLDEADRMLDKGFEQDIKDIVSAMPSSRKRQTVMFTATWPISVRKLATTFMKEPVTVTIGGDLSSDIRANTRIKQIVEVVKPENKESRLLSLLNQYQRGRNAMDKVLVFCLYKKEATRIERFIRSKGFKVAGIHGDMNQTERFNSLDAFKSGSVPVLVATDVAARGLDIPAVKLVLNVTFPLTVEDYVHRIGRTGRAGSDGLAITMFTENDKALSGGLVNILKGANQDIPEALLKFGTTVKKKQHDSYGAFFREADTMKTATKIKFDD
What is the function of this protein?
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis.  Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: KEFG_SHIDS
Sequence: MMSQPAKVLLLYAHPESQDSVANRVLLKPATQLSNVTAHDLYAHYPDFFIDIPREQALLREHEVIVFQRPLYTYSCPALLKEWLDRVLSRGFASGPGGNQLAGKYWRSVITTGEPESAYRYDALNRYPMSDVLRPFELAAGMCRMHWLSPIIIYWARRQSAQELASHARAYGDWLANPLSPGGR
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefB.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefG, Putative quinone oxidoreductase KefG.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NICA_PSEPU
Sequence: MRDAEQSFTRIEAIRKANSDPSYVNDRIYRLMYKEDLYIAAYEKIKSKPGNMTPGQDGTTLDEFSIRTIRNIINKMKDESFTFRGARRVLIPKANGKTRPLSVAPPTDKVVQEVIRSILEAIYEPTFSKNSHGFRAGKSCHTALKQVRESWSGVTWVIEGDIKGCFDNISHSKLIDQLRLRIKDERFINLIRKALNAGYFENGAFFSATLGTPQGSIISPILANVFLDQLDRKVEQLIKDHHQGEEGDKITDPAYRKLQRQKTSLRKKAEKQEGAERDATLSLAREANSKLLSMSPYLTRNNGFIRVKYVRYADDWIIGVNGPKLLAEELRSVVGEFLENAGLELSIEKTHIRHAKSETAKFLGTNLRIGSENSKIMKVLRNGKKFPKRVAGWTPVMYAPMNELIAKLHSRGFCDPKGNPTTVNKWIFLDDNQIVEQIGSVWRGIMNYYSFIDQFSMLSRIQFILQHAAAKTLATKHRSSRSKIFSKHGANLRVRIRDKAGNVIRQVEFPLIKSWKTSPKRFKIGTVDTNFLERSLRLRTRSKLYSPCVICESGDRVAMHHVRHIRKMGQEIKGFKRVLVSLNRKQIPVCHECHLKIHQGKYDGISLKDFALPHTAAA
What is the function of this protein?
It is hypothesized that the pyrrolidine ring of nicotine is oxidized by NicA to form N-methylmyosmine.  The spontaneous ring opening of N-methylmyosmine due to the addition of water generates pseudooxynicotine, which is further oxidized to 3-succinoylpyridine (SP) by NicA through two hypothesized unstable compounds and the removal of methylamine.
What are the official names of this protein?
Putative nicotine oxidoreductase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the bacterial reverse transcriptase family.
Protein: SYR_SALHS
Sequence: MNIQALLSEKVSQAMIAAGAPADCEPQVRQSAKVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLSGIASKVEIAGPGFINIFLEPAFLAEQVQQALASDRLGVSQPTRQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHHVIRANHVGDWGTQFGMLIAWLEKQQQENAGDMALADLEGFYRDAKKHYDEDEAFAERARNYVVKLQSGDAYFREMWRKLVDITMTQNQITYDRLNVTLTRDDVMGESLYNPMLPGIVADLKAKGLAVESEGATVVFLDEFKNKEGDPMGVIIQKKDGGYLYTTTDIACAKYRYETLHADRVLYYIDSRQHQHLMQAWTIVRKAGYVPDSVPLEHHMFGMMLGKDGKPFKTRAGGTVKLADLLDEALERARRLVAEKNPDMPADELEKLANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKADIDEQALASAPVIISEDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDVAGLFSGFYEHCPILSAENDAVRNSRLKLAQLTAKTLKLGLDTLGIETVERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS23_BOVIN
Sequence: MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  Plays an important role in translational accuracy.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: RN152_DANRE
Sequence: MDSLSQSSRLECQICFNYFSQRRLPKLLHCQHTCCSVCLSQMRLSQREIRCPWCRCVTQIPIGLSVSHLPDDPEVLSVISVSQSSEHTPIFIHLPNNGCYLLPVSLDTDGTPLPGQPTCHVGPKSIGVFDVSDGQNHVLGHDGLGDGMEEEEVVVVKTTAWTGVCTVLLVAFILIFLLGIVLHNMSCVSKRFTIISCG
What is the function of this protein?
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation.  Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability.  Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase rnf152, RING finger protein 152, RING-type E3 ubiquitin transferase rnf152.
What is the protein family that this protein belongs to?
Belongs to the RNF152 family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass membrane protein.
Protein: METXS_BURMS
Sequence: MESIGVVAPHTMHFAEPLRLQSGSVLGNYQLVVETYGELNAARSNAVLVCHALNASHHVAGVYADDPRSTGWWDNMVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMSIDPATGTPYGARFPVVTVEDWVHAQARVADAFGIERFAAVMGGSLGGMQALAWSLLYPERVAHCIDIASTPKLSAQNIAFNEVARSAILSDPDFHGGDYYAHGVKPRRGLRVARMIGHITYLSDDDMAEKFGRALRRADGALDAYNFNFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFNGDLSAALAHTKAKYLIASFMTDWRFAPARSREIVKALLDNRRSVSYAEIDAPHGHDAFLLDDARYHNLVRAYYERIAEEVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECD_ACAM1
Sequence: MLKQQRFLLALIALLVVGALIVVTPFGKQYGLGKINLGLDLRGGSQLTLQVNPTEEVKDITPNVMEAVQTVVANRLNPEGVSEIVVQTVGSQQILVQLPGVSDPKDAEQLLSQVAQLDFRRPNNAILAQVNVRSSELQRLLQKLPEAEKAGDAAALAKLQGEVQQKQKQLTELQDQFFVKTDLTGEDLNDAGYAISQSQPNKWDVTLRFDVDGGKKFAALTKSLAGTGQPLGIFLDGKSISQATVSDRFKANGITGGAAIITGNFELEDAKLLANQLKGGSLPVPVKVEEIRTVGATLGQDSIRQSVYAGIGGLILVLIFMGVWYRLPGLIADVALCVYGLLTFACYVLFGVTLTLPGIAGFILSIGMAVDANILIFERTREELRSGKTLYRSIESGFYRAFTSILDSNVTTLIACGVLYWLGSGLVRGFAVTLGIGVAVSMFTAITCSRTLMFTAISLPNLRKIELFDSKRAVS
What is the function of this protein?
Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.
What are the official names of this protein?
Protein translocase subunit SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.