PharMolix/UniProtQA huggingface dataset:
Protein: COX3_RAPCA
Sequence: MTHQTHAYHMVNPSPWPLTGALSALLMTSGLAMWFHFNSTILLMIGLTTNTLTMYQWWRDVIRESTFQGHHTPTVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRYPMLQALFITIALGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: THA_ELECQ
Sequence: IDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEENRERRRKEEMIKTMQQRPEPNSEEWELIR
What is the function of this protein?
Nuclear hormone receptor that can act as a repressor or activator of transcription.  High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
What are the official names of this protein?
Thyroid hormone receptor alpha, Nuclear receptor subfamily 1 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPA_DICDI
Sequence: MQLEKMLTEVNIERSKFNTYNVLLQYIKAVTQKYNLNKVSSKYGKVLFIKDGVVKVSGLSQIKIGEKVEFVGKNLYGMALNLEATSVGIVIFGEDTAIYEGVIVKRCEQNFAIKVDKTMLGRVVDVLGQPIDGLGELKDTKTTRVMSVERKAPGIVTRKSVHESMLTGVKIVDALLPIGRGQRELIIGDRQTGKSAIAVDAILNQQVNKDIVCIYVAVGQKKSTVRRLVEMLNTKGALEYTIVVVSTASDAAPLQFLAPYTGCTIGEYFRDEGKHALIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKLNEKYGCGSLTAFPIVETQAGDVSAYIPTNIISITDGQIFLEKELFNKGIRPAVNVGLSVSRVGSAAQSAVMKKLAGALKLELAQYRELARFEQFSSNADAVTTQILKKGKLTIELLKQVNNNPMSIGLEALMIYAMGTSYFQNLDLSLVRSEETKLLNYINSIASFKLYAACVDAVKAFNPKDTVFAEMCQSYVK
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.  Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
What are the official names of this protein?
ATP synthase subunit alpha, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: GATA_STRSV
Sequence: MTFNHKTIEELHDLLVKKEISAVELTQATLADIKEREAAVDSFITVSEEEALAQAAALDAKGIDADNLMSGIPLAVKDNISTKGILTTAASKILYNYKPIFDATSVEKLYGKDMIIVGKTNMDEFAMGGSSENSYFKTTKNAWDSSKVPGGSSGGSATAVASGQVRLSLGSDTGGSIRQPASFNGVVGLKPTYGRVSRFGLIAFGSSLDQIGPFSQTVKENAQLLNVISGNDPKDSTSSQEEVPDFTSKIGQDIKGMKIALPKEYMGEGIDSKVKETILAAAKHLESLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRAEGIENLEDVYVKSRSEGFGEEVKRRIMLGTFSLSSGYYDAYFKKAGQVRTLIMQDFAKVFEKYDLILGPTAPTVAYDLGSQNQDPVAMYLADLLTIPVNLAGLPGISIPAGFVDGLPVGLQLIGNHFDEATIYQTAAAFEATTDYHKQQPVIFGGEK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: LUXS_HELPJ
Sequence: MKMNVESFNLDHTKVKAPYVRIADRKKGVNGDLIVKYDVRFKQPNRDHMDMPSLHSLEHLVAEIIRNHANYVVDWSPMGCQTGFYLTVLNHDNYTEILEVLEKTMQDVLKAKEVPASNEKQCGWAANHTLEGAQNLARAFLDKRAEWSEVGV
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: RECF_ECOHS
Sequence: MSLTRLLIRDFRNIETADLALSPGFNFLVGANGSGKTSVLEAIYTLGHGRAFRSLQIGRVIRHEQEAFVLHGRLQGEERETAIGLTKDKQGDSKVRIDGTDGHKVAELAHLMPMQLITPEGFTLLNGGPKYRRAFLDWGCFHNEPGFFTAWSNLKRLLKQRNAALRQVTRYEQLRPWDKELIPLAEQISTWRAEYSAGIAADMADTCKQFLPEFSLTFSFQRGWEKETEYAEVLERNFERDRQLTYTAHGPHKADLRIRADGAPVEDTLSRGQLKLLMCALRLAQGEFLTRESGRRCLYLIDDFASELDDERRGLLASRLKATQSQVFVSAISAEHVIDMSDENSKMFTVEKGKITD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_NOCSJ
Sequence: MTRTARIERQTSESKVLVEVDLDGTGRHDVSTGVGFYDHMLTAFARHALVDLTVQTDGDTHIDAHHTVEDTAIALGQALRQALGDKRGIRRFGDATVPLDEALVQAVVDVSGRPYCVHTGEPEGQQYVQLGGTTPAYLGSLTQHVFESIAFHGHFALHVRVLAGREPHHIVETQFKAVARAFRDAVALDPRETGIPSTKGAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SET11_SCHPO
Sequence: MSNKQNIESEVSWVKSKGAFVHPSLEFSVIPDAGSCVLANNDINENTVLLKLPPNILINKRTCSRYSFRDKLTSFQFLSWLISEDVHSNLEISPYYTKALPQGFSFHPVTLTSDHPLWSILPDEVRNSLLERKNVMAFDYEQVKKFVSVDQPTFQWGWLCVNTRCLYYDTGSKNTEDHLTLAPIFEYFNHSPEAQTALINTRGTITIKSTRRIDKGEQIFLCYGPHGNDKLFTEYGFCLSNNPNISIQLDRFIEFDKWQQSFLQDHGYWNDYTCSLHGASFRTLVGVRTLLVSPSEKLNDASYDQTRRVLQYINGFSDGSRDRQDVEDYLKKVLQELLCEAEECKEKVKGISDGSYVFICAEQLWKDRIMCCQYLMEHSFE
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates 60S ribosomal protein L12 (rpl1201 and rpl1202) at 'Lys-4' and may dimethylate L12 also at 'Lys-40' and 'Lys-41'.  Overexpression causes a severe growth defect.  Has a role in meiosis.
What are the official names of this protein?
Ribosomal lysine N-methyltransferase set11, Meiotically up-regulated gene 76 protein, SET domain-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: F16PA_GEOSL
Sequence: MPFSEPGKTKFQVDLRRHLRNQDISDNLVHLICEIAEASKYVINAVRTGDLGVAGTSNLYGEEQLALDVLSDRIIRKRLIHSGVVCNIASEEMDEIFQAQADADGLYSVAYDPLDGSSLVDVNLAVGTIVSIYEGCNLLQKGRNQVAAMYILYGPRVSLVYSVGKGVHEFTMNHLMEYTLSRENVTMKPDGDIYSPGGLRKKYLPETEKFVQHLESKGSKLRYSGGFVPDINQVLMKGKGIFMYPALNGSPNGKLRVLFELNPMAYLIENAGGAATDGKTPILDIEPQSLDQRAPIFIGCSNDVATAMEFMGG
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAK21_HUMAN
Sequence: MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDWKRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEEDSISVSDAPGSCIIDCNENTRKKSQKETEGLHCEYAAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRGTSPLPAGQVPVTLQPQTQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGRAPYPQPPTRRLNPTAPPSRQGSELHEIIDKSRKEGDTEAWQFPVMLEPMPPGEGAQEGEPPTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLLPSQFLQFKTWWIDGVQEQVQRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVRAICLRAWEKIQDPGSTCPSFNTVRQSSKEPYPDFVARLQDVAQKSIADEKARKVIVELMAYENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVRTFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFDKNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQGQQPPLSQVFQGISQLPQYNNCPPPQAAVQQ
What is the function of this protein?
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle.  During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell.  Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA.  Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
What are the official names of this protein?
Endogenous retrovirus group K member 21 Gag polyprotein, HERV-K_12q14.1 provirus ancestral Gag polyprotein, Gag polyprotein.
What is the protein family that this protein belongs to?
Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system).
Protein: ORTHL_ARATH
Sequence: MTRVNQLPCDCVSTAEESLTSGTCITPTHVTSLSSPLDRSGDVDPLPVSDESGGSKADESMTDADETKKRKRILSGDCEADENNKSDGEIASLNDGVDAFTAICEDLNCSLCNQLPDRPVTILCGHNFCLKCFDKWIDQGNQICATCRSTIPDKMAANPRVNSSLVSVIRYVKVAKTAGVGTANFFPFTSNQDGPENAFRTKRAKIGEENAARIYVTVPFDHFGPIPAEHDPVRNQGVLVGESWENRVECRQWGVHLPHVSCIAGQEDYGAQSVVISGGYKDDEDHGEWFLYTGRSRGRHFANEDQEFEDLNEALRVSCEMGYPVRVVRSYKDRYSAYAPKEGVRYDGVYRIEKCWRKARFPDSFKVCRYLFVRCDNEPAPWNSDESGDRPRPLPNIPELETASDLFERKESPSWDFDEAEGRWRWMKPPPANHEQRERMKMAMTCLLLFVLIILVGSSSILYQY
What is the function of this protein?
E3 ubiquitin-protein ligase.  May participate in methylation-dependent transcriptional regulation.  Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11.
What are the official names of this protein?
E3 ubiquitin-protein ligase ORTHRUS-LIKE 1, ORTH-LIKE 1, Protein VARIANT IN METHYLATION 6, RING-type E3 ubiquitin transferase ORTHRUS-LIKE 1.
What are the subcellular locations of this protein?
Nucleus. Membrane; Single-pass membrane protein.
Protein: OBG_ENTFA
Sequence: MSMFLDQVTIDVKAGKGGDGMVAFRREKYVPDGGPAGGDGGRGGDVVLVVEEGLRTLMDFRFNRHFKATPGENGMSKGMHGRGSEDLLVKVPPGTTVRDAETGALIGDLIENGQTLVVAKGGRGGRGNIRFASPRNPAPEIAENGEPGQERKIELELKVLADVGLVGFPSVGKSTLLSVISSARPKIGAYHFTTLVPNLGMVTTSDGRSFAAADLPGLIEGASQGVGLGTQFLRHIERTRVILHVIDMSGMEGRDPYEDYLAINKELASHNLRLMERPQIIVANKMDMPEAEENLAKFKEQLAKERTDEYADELPIFPISGVTRKGIEPLLNATADLLEVTPEFPLYEDEVVEEETVRYGFQPEGPEFTIDREPDASWVLSGEKLEKLFEMTNFDHDETVMRFARQLRGMGVDEALRARGAKDGDIVRIGNFEFEFVE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_ECO81
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRSEKTEAAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: EFTS_SULSY
Sequence: MAVDAKLVKTLREMTGAGMLECKSALEEANGDLELAVEILRKKGVAKAAKKAGRETKEGLIHAYIHAGGRIGVLLELNCETDFVARNELFKELANEIALQIAAMKPQYVKREDVPREVVEKEGEIAREAAVAEGKPAHIAEKIAEGKLEKFYKEVCLYEQPYIKDDKKTIEELVKEYIAKIGENIQVRRFCRYELGE
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_ACIB5
Sequence: MSGSTITPWVVGNWKMNPMRANANQLIEEFKQLLQQNQIADENCHVGVAPVSIALTTVQAQLQDAARTVHTVAQDVSRVAGTGAYTGEVSAELLKDSQINFVLVGHSERRDIFGDNVEILKAKLQNALNAGMTVIYCVGESLEQREQGQAEQVVLQQICDIAPVVTAEQWQNQVVIAYEPIWAIGTGKTASPQDAQAMHAKIREGLCQLTPAGSNIAILYGGSVKAENAVELAACPDINGALVGGASLKAASFYQIVQAFAQSK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUKF_ESCF3
Sequence: MSEFSQTVPELVAWARKNDFSISLPVDRLSFLLAVATLNGERLDGEMSEGELVDAFRHVSDAFEQTSETIGVRANNAINDMVRQRLLNRFTSEQAEGNAIYRLTPLGIGITDYYIRQREFSTLRLSMQLSIVAGELKRAADAAEEGGDEFHWHRNVYAPLKYSVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRAAISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQTYFDEPWALTYANADRLLDMRDEEMALRDEEVTGELPEDLEYEEFNEIREQLAAIIEEQLAVYKTRQVPLDLGLVVREYLAQYPRARHFDVARIVIDQAVRLGVAQADFTGLPAKWQPINDYGAKVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: MENC_SALAR
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLRDGEREGWGEISPLPGFSSETWEEAQTALLTWVNDWLQRSDALPEMPSVAFGASCALAELTGVLPAAADYRAAPLCTGDPDDLVLRLADMPGEKIAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKAQQFAKYVNPDYRPRIAFLEEPCKTRDDSCAFARETGIAIAWDESLREPDFVFEAQEGVSAVVIKPMLTGALDKVRAQVAAAHALGLTAVISSSIESSLGLTQLARIAAWLTPGTLPGLDTLHLMQTQQVRPWPGSALPCLNRDELERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: XPO4_MOUSE
Sequence: MMAAALGPPEVIAQLENAAKVLMAPPSMVSNEQRQHAEHIFLSFRKSKSPFAVCRHILETSKVDYVLFQAATAIMEAVVREWVLLEKGSIESLRTFLLTYVLQRPNLQKYVREQILLAVAVIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSSSSKTSNIGLSMEFHGNCKRVFQEEDLRQIFMLTVGVLQEFSRRENLSAQMSSVFQRYLALANQVLSWNFLPPKLGRHYIAMFESSQNVLLKPTESWREALLDSRVMELFFTVHRKIREDSDMAQDSLQCLAQLASLHGPIFPDEGSQVDYLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVLTAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVRDDKHFHKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDRDQFSDQLASVGMLGRIAAEHCMPLLTSLLEERVTRLHGQLQRHQQQFLASPGSSTIDNKMLDDLYEDIHWLILVTGYLLADDTQGETPLIPPEIMEYSIKHSSEVDINTTLQILGSPGEKASSIPGYSRTDSVIRLLSAVLRVSEVESRAIRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQISLPLSTAFGADTEGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLVIQCENWWNLAKQFASRSPPLNFLSSPVQRTLMKALVLGGFAHMDTETKQQYWTEVLQPLQQRFLRVINQENFQQMCQQEEVKQEITATLEALCGIAEATQIDNVAILFNFLMDFLNNCIGLMEVYKNTPETVNLIIEVFVEVAHKQICYLGESKAMHLYEACLTLLQVYSKNNLGRQRIDVTAEEEQYQDLLLIMELLTNLLSKEFIDFSDTDEVFRGHEPGQAAGRSVSAADVVLYGVNLILPLMSQDLLKFPTLCNQYYKLITFICEIFPEKIPQLPEDLFKSLMYSLELGMTSMSSEVCQLCLEALTPLAEQCAKAQETDSPLFLATRHFLKLVFDMLVLQKHNTEMTTAAGEAFYTLVCLHQAEYSELVETLLSSQQDPVIYQRLADAFNKLTASSTPPALDRKQKMAFLKSLEEFMANVGGLLCVK
What is the function of this protein?
Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (By similarity).  In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form (By similarity).  Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (By similarity).  Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (By similarity).  XPO4 then return to the nuclear compartment and mediate another round of transport (By similarity).  The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).  Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 (PubMed:27306458).  Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (By similarity).  Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (PubMed:19349578).
What are the official names of this protein?
Exportin-4, Exp4.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: RL17_DESAH
Sequence: MRHRKSGAKLNRTSSHRKAMFRNMVTSLFKHSSIKTTEAKAKELRKLADKMVTLAKRGDLHARRQAFSIIREKDVVHQLFNDAPSKFASRQGGYTRITKLGLRSGDAAPMTTIELICDEV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: ERFK_KLEAE
Sequence: MRRVKLLCTALMLLASHGALAVSYPLPPEGSRLVG
What are the official names of this protein?
Probable L,D-transpeptidase ErfK/SrfK.
What is the protein family that this protein belongs to?
Belongs to the YkuD family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SRP54_METM5
Sequence: MLDKLGQNLSDALNKIKNATFVDKKLVKEVIKDIQKALIQSDVNVKLVFNMSKEIERKAIEEAPPKGLSKKEHIVKIVYDELVKLLGETTQKLELDPSKKSVILLIGIQGSGKTTSAAKLARYIQKKGLRPGLIAADVYRPAAYQQLKQLSEKINVPLFGDETRTKTPVDITKEGMEKLKKVDVIIIDTAGRHKEEESLLAEMKEMKDLTNPNEIILVIDGTLGQQAKNQAKAFKESVSEIGSILVTKLDGSAKGGGALSAVAEINAPIKFIGTGEGVDNLEQFDPKKFISRILGLGDLDSLLEKTEDIMDESTEESIDSILKGKFTLIELYAQLETISKMGPMKQILSMIPGMGGNLPKEAAQLTEDKLKRYKIMMDSMTLEEKENPELIKTSRLQRIAKGAGVKQDEIKDLLKYYSTTKNAFGNLKRGKMPKMGGQMGQIMRQLMYKD
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle 54 kDa protein, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: RPI1_CAEEL
Sequence: MPTPSTKKKVKKVAEDPLSSSGVSSLSGISSYNIRKISIYKNGDRYHRGVKFVINPRVIKDMEPLLNQVNDRIELSHGAKKLYTTDGKIVNSIKELEDGKIYVAASAQFIPMRYGEFAEKVWKPPSRKHSPIMSSDRIKTARTRSQDPSKRRQPQNSGSSAPTGSGVQRSRSVRTLAEDRKSRRDANPARPNVNGASNAPKKFDGARPKAPPARQTIPKPKKILTTSTTNKKPPTPKRKVSKKVLGAAAAAGVTVVGAAAIGAVAAAKRSTPKPIPTAVSDVSTASSIPIPNVTGAAEILEFPEEEKKIDMATIHRTPTPPVVASRPATAKAPGTPANRSATALEAKSVSQQPTPESSEEEEDEGNGDEDDDEEVEDDEEDAGSDEAEEEPSDEEEEDEETEEEEEEEEEEEEDDDESRVETPASRKSSSAVSFSGSTEEDHKKGDEAKK
What are the official names of this protein?
Protein rpi-1.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Single-pass membrane protein. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton. Note=Localizes to the base of the cilium. Localizes to ciliary and cytoplasmic microtubules.
Protein: PUR9_PSEA7
Sequence: MTDQTTRLPIRRALISVSDKTGVVDFARELVALGVEILSTGGTYKLLRDNGIAAVEVADYTGFPEMMDGRVKTLHPKVHGGILGRRDLDGAVMEQHGIKPIDLVAVNLYPFEATVARPDCDLPSAIENIDIGGPTMVRSAAKNHKDVAIVVNAGDYAAVVEALKAGGLTYAQRFDLALKAFEHTSAYDGMIANYLGTIDQTRDTLGTADRGAFPRTFNSQFVKAQEMRYGENPHQSAAFYVEAKKGEASVSTAIQLQGKELSFNNVADTDAALECVKSFLKPACVIVKHANPCGVAVVPEDEGGIRKAYDLAYATDSESAFGGIIAFNRELDGETARAIVERQFVEVIIAPKISAAAREVVAAKANVRLLECGEWPAERAPGWDFKRVNGGLLVQSRDIGMIKAEDLKIVTRRAPTEQEIHDLIFAWKVAKFVKSNAIVYARNRQTVGVGAGQMSRVNSARIAAIKAEHAGLEVKGAVMASDAFFPFRDGIDNAAKAGITAVIQPGGSMRDNEVIAAADEADIAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: SEPT3_MOUSE
Sequence: MSKGLPEARTDAAMSELVPEPRPKPAVPMKPVSINSNLLGYIGIDTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPVSVDTEESHDSNP
What is the function of this protein?
Filament-forming cytoskeletal GTPase (By similarity).  May play a role in cytokinesis (Potential).
What are the official names of this protein?
Neuronal-specific septin-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Synapse.