PharMolix/UniProtQA huggingface dataset:
Protein: ILVE_STAAW
Sequence: MSQAVKVERRETLKQKPNTSQLGFGKYFTDYMLSYDYDADKGWHDLKIVPYGPIEISPAAQGVHYGQSVFEGLKAYKRDGEVALFRPEENFKRLNNSLARLEMPQVDEAELLEGLKQLVDIERDWIPEGEGQSLYIRPFVFATEGALGVGASHQYKLLIILSPSGAYYGGETLKPTKIYVEDEYVRAVRGGVGFAKVAGNYAASLLAQTNANKLGYDQVLWLDGVEQKYIEEVGSMNIFFVENGKVITPELNGSILPGITRKSIIELAKNLGYEVEERRVSIDELFESYDKGELTEVFGSGTAAVISPVGTLRYEDREIVINNNETGEITQKLYDVYTGIQNGTLEDKNGWRVVVPKY
What is the function of this protein?
Acts on leucine, isoleucine and valine.
What are the official names of this protein?
Probable branched-chain-amino-acid aminotransferase, BCAT.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: ACCD5_MYCTO
Sequence: MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEKVHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVTGYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHTHMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITRLLDDEFLEIQAGYAQNIVVGFGRIGGRPVGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTDQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNLAWPTAQIAVMGASGAVGFVYRQQLAEAAANGEDIDKLRLRLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL
What is the function of this protein?
Component of a biotin-dependent acyl-CoA carboxylase complex.  This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate.  When associated with the alpha3 subunit AccA3, is involved in the carboxylation of acetyl-CoA and propionyl-CoA.
What are the official names of this protein?
Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta5 subunit, Acetyl-CoA carboxylase, ACC, Propionyl-CoA carboxylase, PCC.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
Protein: TBP1_ARATH
Sequence: MTDQGLEGSNPVDLSKHPSGIVPTLQNIVSTVNLDCKLDLKAIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEDFSKMAARKYARIVQKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYSHAAFSSYEPELFPGLIYRMKVPKIVLLIFVSGKIVITGAKMRDETYKAFENIYPVLSEFRKIQQ
What is the function of this protein?
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID.  Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
What are the official names of this protein?
TATA-box-binding protein 1, AtTBP1, TATA sequence-binding protein 1, TBP-1, TATA-binding factor 1, TATA-box factor 1, Transcription initiation factor TFIID TBP-1 subunit.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYB_NATTU
Sequence: MTNIRKSHPLTKIINNSFIDLPTPSSISSWWNFGSLLGICLAVQILTGLFLAMHYTADTATAFNSVTHICRDVNYGWILRYMHANGASMFFICLYLHVGRGLYYGSYTYTETWNVGIMLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIISAMVMVHLLFLHETGSNNPTGIPSNMDMIPFHPYHTIKDILGLLLMLTALLVLVMFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAIIPLLHTSKQRSMMFRPISQCLFWLLVADMLTLTWIGGQPVEHPYIIIGQLASILYFSIILIFMPLASLTENHLLXW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RR8_CHLSC
Sequence: MGKDTIADIITSIRNADMEKKGTVRIASTNINISENIVQILLREGFIENVRKHRENNKYFLVSTLRHRRNRKGAYRNILKRISRPGLRIYSNYQRIPRILGGMGIVILSTSRGIMTDREARLEGIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS2_DINSH
Sequence: MALPDFNIRQLLEAGVHFGHQTQRWNPRMAPYIYGDRNGIHIMDLTQTVPMLDQALQAVRDTVAKGGRVLFVGTKRQAQKPIAEAAERCAQYYMNHRWLGGTLTNWKTVSNSIGRLKSIDEAMEGGFEGLTKKERLGMERDQGKLQASLGGIREMGGVPDLIFVIDVKKEDLAIAEANKLGIPVVAVVDTNCSPDGVDYVIPGNDDAARAIALYCDLVARAALDGMSAQLGAAGVDLGALEEGGVEEALAEEAAAPAES
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: CAIA_ECOSE
Sequence: MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDSLLIPEEHGGLDAGFVTLAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFRGTGKQMWNSAITEPGAGSDVGSLKTTYTRRNGKIYLNGSKCFITSSAYTPYIVVMARDGASPDKPVYTEWFVDMSKPGIKVTKLEKLGLRMDSCCEITFDDVELDEKDMFGREGNGFNRVKEEFDHERFLVALTNYGTAMCAFEDAARYANQRVQFGEAIGRFQLIQEKFAHMAIKLNSMKNMLYEAAWKADNGTITSGDAAMCKYFCANAAFEVVDSAMQVLGGVGIAGNHRISRFWRDLRVDRVSGGSDEMQILTLGRAVLKQYR
What is the function of this protein?
Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
What are the official names of this protein?
Crotonobetainyl-CoA reductase, Crotonobetainyl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_CORK4
Sequence: MAVPKRRMSRANTHTRRSQWKANNAPLQEVRVNGNTTRLPRRLVKAAQLGLVETD
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: THII_STAAR
Sequence: MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITNRLSKIFGIKSISPVLKVEKSIEAMSAETIKFAQQFEENSTFKIDVKRADKNFPMDTYELQRELGGTVLKQIENVSVNVKRPDHEIRVEVRLDAIYMYEEVVPGSGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGAYAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFDKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_DESVM
Sequence: MIPGKGRYFFTSESVTEGHPDKVADQISDAVLDVLLAQDPMSRVACETLVTTGMAFIAGEIRTKGFADLPEVVRSTIRNIGYNSSEMGFDWKTCAVISSIDKQSGDIAQGVDRGNPEDQGAGDQGMMFGFACDETPTLMPAPIYWAHQLSQRLTQVRKDGILDFLRPDGKTQVSFEYVDGKPVHINNVVVSSQHADNVSNDTIREGIIEEVIRKTLPEGLMADDCEIFINTTGRFVIGGPMGDCGLTGRKIIQDTYGGAGHHGGGAFSGKDASKVDRSGAYMGRYIAKNVVKAGLAPKCEVQIAYCIGVAEPVSVLVSSLGSSELSDEVLTRAVREVFDLRPYHIIKRLDLNRPIYGKTTCYGHFGRELPEFTWEQCDAVADLRTAAKI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPF_MOOTA
Sequence: MAFWQGLINWLGYGHEGEEPVMEKPVLEAETTPVTPAKGKLVGLPTARNAMRLVIARPQSFEQAAGLAENLKNYRPLIVNVEGIPVEEARRIIDFLSGAAYALGGRVRKVTSGIFLFTTSNVDLSGDLEDQIPGGLNWLEAAGRGR
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: VATF1_DROME
Sequence: MALHSAIKGKLISVIGDEDTCVGFLLGGVGEINKNRHPNFMVVDKNTAVSELEDCFKRFLKRDDIDIILINQNCAELIRHVIDAHTSPVPAVLEIPSKDHPYDASKDSILRRARGMFNPEDLVR
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit F 1, V-ATPase subunit F 1, V-ATPase 14 kDa subunit, Vacuolar H+ ATPase subunit 14-1, Vacuolar proton pump subunit F 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase F subunit family.
Protein: CASA1_CAMDR
Sequence: MKLLILTCLVAVALARPKYPLRYPEVFQNEPDSIEEVLNKRKILELAVVSPIQFRQENIDELKDTRNEPTEDHIMEDTERKESGSSSSEEVVSSTTEQKDILKEDMPSQRYLEELHRLNKYKLLQLEAIRDQKLIPRVKLSSHPYLEQLYRINEDNHPQLGEPVKVVTQEQAYFHLEPFPQFFQLGASPYVAWYYPPQVMQYIAHPSSYDTPEGIASEDGGKTDVMPQWW
What is the function of this protein?
Important role in the capacity of milk to transport calcium phosphate.
What are the official names of this protein?
Alpha-S1-casein.
What is the protein family that this protein belongs to?
Belongs to the alpha-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSRP_ALISL
Sequence: MAKKKSKDKAGSNTIAMNKQARHEYFIEDEIEAGVELQGWEVKSLRSGKVNIAESYVYVRDGEIFISGMNITPLQAASTHVVANPTRVRKLLMSRKEIDNLIGRVNREGMTLVATTMYWVRSWAKIKVGVAKGKKLHDKRTDSKEKDWNRDKARIMKSSLR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ODAD4_DANRE
Sequence: MFDNEEGQGPKSTFTTYMAEGDQLFQRGEYVKAVESFTTALTLQPDDKNCLVSRSRCYVKLGDAENALKDAESSLKDNKNYFKGLYQKAEALYTMGDFEFALVYYHRGHKLRPELQEFRLGIQKAQEAIDNSVGSPSSVKLVNKGDLSFFHNGVHPQNLNPSNKKESKKHSKKTDKGEKTAKQLLGELYSDREYLKKLLQDEDLVKCKIRSGERVQDLIVGSISYLDTRMAFWQQQKPIYARQRDRKLMQQQWSKVLHKPPSDPTRYVLSSLEEIDTALSAGYTESGLNKARELMKVVKDWSEDALPNKNEVLGNLHSYIGNALMDLGNMDRALHHHEKDLELAKKCDLTDSKSRALDNIGRVYARIGKFQQAIEVWEKKLPLACGGLEKAWLFHEIGRCYLELKRYMEARDYGSRSLMAADDISDEKWQLNASVLMAQAELKLSNYKASVLHFERALERAKLLQDDSASEAIQKALCEARLRVTQ
What is the function of this protein?
Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule.  Plays an essential role for the assembly of ODA-DC and in the docking of ODA in ciliary axoneme.
What are the official names of this protein?
Outer dynein arm-docking complex subunit 4, Tetratricopeptide repeat protein 25, TPR repeat protein 25.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: NQO5_PARDE
Sequence: MSEALSDEALLELAEHIAVRRENDVISTQAVGELTVNATLSGVIGLIEFLRNDPNCRFSTLIDITAVDNPARPARFDVVYHLLSMYQNQRIRVKVQVREDELVPSLIGVFPGANWYEREVFDLFGILFSGHSDLRRILTDYGFRGHPLRKDFPTTGYVEVRWSDIEKRVVYEPVNLVQEYRQFDFLSPWEGAKYVLPGDEKAPEAKK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase chain 5, NADH dehydrogenase I, chain 5, NDH-1, chain 5.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TX35B_PHONI
Sequence: CGDINAACKEDCDCCGYTTACDCYWSSSCKCREAAIVIYTAPKKKLTC
What is the function of this protein?
Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav) (By similarity).  Inhibits glutamate uptake in rat brain synaptosomes (PubMed:14757211).  In vivo, induces immediate excitatory effects when injected intrathoracically in houseflies and cockroaches (PubMed:14757211).
What are the official names of this protein?
Delta-ctenitoxin-Pn1b, Delta-CNTX-Pn1b, Neurotoxin PnTx4-3.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 03 (Tx2) family. 05 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YRAF_BACSU
Sequence: MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTETASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNMNLFPDETNRKGMFDRTPDEH
What are the official names of this protein?
Spore coat protein F-like protein YraF.
What is the protein family that this protein belongs to?
Belongs to the CotF family.
What are the subcellular locations of this protein?
Spore coat.
Protein: LPXD_CUPPJ
Sequence: MQTPTLGQLATENGAQVVGDPDLAIIGLAPLDQAGSGELSFLSNPLYLAQALSSAAGAVIVSAADLERIRAEGQADGRNWLVARNPYVCFARIAQRFDKANQDARTGIDPRASVAADVTVPASCFIGPNVVIESGARIGERVRIVANSFVGAHAEIGDDSLLYANVSVYHHCVVGARAILHSGVVIGADGFGFAPDIGPTGVEYVKIPQTGRAVLGNDVEVGANTAIDRGAMADTVIEDGCKIDNQVQIAHNVRVGAHTVIAGCAAVSGSTHIGRFCVIGGAANFSGHLKIADRTTVSGGTSITKSITKPGGHFTSVFPFLPHGEWERNAAIVRGLTKLRERVMQLERRLRGQSAGTQTSQD
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: PCYA_GLOVI
Sequence: MHEGNRSPRPMRMEAKTVKPRHPLVSRLAELLVSTWGEYLQLEPYHLPADLGFVEGQLEGDRLTIVNRCYQSRVFRKLHLELATIGPNLDILHCVMYPRPQFDLPIYGTDIVASTQMVSAAIVDLSPVRGELPPAYLAGLEPSFARCTDFGQLRNLPPWGTIFSPRCVFARVVTPTEADLFMEISRAYLRFHCEQAARAEAVDTATEAQILAGQRHYCEQQQQNDKTRRILAQAFDEAWAERYIRTVLFDLPQ
What is the function of this protein?
Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.
What are the official names of this protein?
Phycocyanobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: FDX2_HUMAN
Sequence: MHVMAASMARGGVSARVLLQAARGTWWNRPGGTSGSGEGVALGTTRKFQATGSRPAGEEDAGGPERPGDVVNVVFVDRSGQRIPVSGRVGDNVLHLAQRHGVDLEGACEASLACSTCHVYVSEDHLDLLPPPEEREDDMLDMAPLLQENSRLGCQIVLTPELEGAEFTLPKITRNFYVDGHVPKPH
What is the function of this protein?
Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:28001042).  The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis.  This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner.  Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly.  Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).
What are the official names of this protein?
Ferredoxin-2, mitochondrial, Adrenodoxin-like protein, Ferredoxin-1-like protein.
What is the protein family that this protein belongs to?
Belongs to the adrenodoxin/putidaredoxin family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion matrix.
Protein: DHA_LYSSH
Sequence: MKIGIPKEIKNNENRVAMTPAGVVSLTHAGHERLAIETGGGIGSSFTDAEYVAAGAAYRCIGKEAWAQEMILKVKEPVASEYDYFYEGQILFTYLHLAPRAELTQALIDKKVVGIAYETVQLANGSLPLLTPMSEVAGKMATQIGAQYLEKNHGGKGILLGGVSGVHARKVTVIGGGIAGTNAAKIAVGMGADVTVIDLSPERLRQLEDMFGRDVQTLMSNPYNIAESVKHSDLVVGAVLIPGAKAPKLVSEEMIQSMQPGSVVVDIAIDQGGIFATSDRVTTHDDPTYVKHGVVHYAVANMPGAVPRTSTIALTNNTIPYALQIANKGYKQACIDNPALKKGVNALEGHITYKAVAEAQGLPYVNVDELIQ
What is the function of this protein?
Catalyzes the reversible reductive amination of pyruvate to L-alanine.  Prefers L-alanine for oxidative deamination, other substrates are poorly reactive.  In the other direction 2-oxobutyrate is almost as reactive as pyruvate.  Ammonia is the sole amino donor for the reductive amination of pyruvate, NADPH is inert.  Reductive amination proceeds through a sequential, ordered ternary-binary mechanism, where NADH binds first followed by ammonia and pyruvate; the products are released in the order L-alanine and NAD(+) (PubMed:488097, PubMed:2340274).  A key factor in the assimilation of L-alanine as an energy source via the tricarboxylic acid cycle during sporulation (By similarity).
What are the official names of this protein?
Alanine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOC_MARMM
Sequence: MSEALKVLGEHIANAQDAAVTGWSIANGELTVEIHRDRIETVLTWLRDDPACRFTTLIDICGVDYPQRAERFEVVYHLLSMHQNHRIRVKLSTDEEAPVPTVIPVYPVADWFEREAFDMYGIVFADHPDLRRLLTDYGFEGYPLRKDFPLTGYVEVRWDEEEKRVVYEPVELVQEYRDFDFMSPWEGAKYILPGDEKAEG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATG7_CRYNJ
Sequence: MAPLQFQPLASQPTPAFWAALAAHKLNHLKLDDSHLPITAQIEPAKRVLINKERVDDTADVGIDGSLVVGGDAFEAERGRLPPNAVSVTGTLKIFNTIEEFKDTSAKKRLFDDLVSQMLESFDTDRPVLNPFLLVTFADLKKYVYHYWFAFPALVSSPAWVMDGEFMPVDEIEDIRKLAQSHFQHNTTAFLLKGAAPHLSAAPLSSCSTFYDKTQSEMVTVVFHDTSSLPSNPGWGLRNVLYYLSAKHGITSLVVICLREGSSSTQASLSLSSPPSTAPAKPPQAVGWERHPSGKLSPRVADLGPMMDPTRLAAQAVDLNLKLIKWRLLPALDLDKISGTRCLLLGAGTLGCYVARILMGWGVRNITLVDSSTVSYSNPVRQPLFTFSDCLNGGLPKAPTAAKKLQEIFPGVNAQGVVLGIPMPGHPISSSDDAVEKDVAKLEALVKSHDAVFLLMDSRESRWLPTVLGRKWGKVVVNAALGFDSFLVMRHGAGAGAGARRIQSDEGGVGEKGLGCYYCNDIVAPTDSLSDRTLDQMCTVTRPGVAPIAAAMAVELLISVLQHPLGVHAPAERPDTAETSTSTKTSPLGCVPHQLRGQMYQWKTQIVEGEAFDRCTGCSDYVLNEYETNGFAFLRRVFNEKDYLEKVTGLDELYRESEKVIEGMEGLDWDSEGEE
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: YQAA_SHIFL
Sequence: MSEALSLFSLFASSFLSATLLPGNSEVVLVAMLLSGISHPWVLVLTATMGNSLGGLTNVILGRFFPLRKTSRWQEKATGWLKRYGAVTLLLSWMPVVGDLLCLLAGWMRISWGPVIFFLCLGKALRYVAVAAATVQGMMWWH
What are the official names of this protein?
Inner membrane protein YqaA.
What is the protein family that this protein belongs to?
To H.influenzae HI_0489.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RLMF_SALDC
Sequence: MSAQKPGLHPRNRHQHRYDLAALCQTTPELTSFLIRTPAGEQSVDFANPQAVKALNKALLAHFYAVTHWDIPPGFLCPPVPGRADYIHHLADLLGETTGSIPAQATILDVGVGANCIYPLIGVHEYGWRFTGSEVSDAAMSSAQAIIQANTGLSRAIRLRRQKDPAAIFTGIIHKNEFYDATLCNPPFHDSAAAARAGSERKRRNLGQNKDDALNFGGQQQELWCEGGEVAFIKKMIAESQSFRRQVLWFTTLVSRGENLPPLYRALTEAGAVKVVKKEMAQGQKQSRFIAWTFMDDDQRRRFITRKR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_BURP6
Sequence: MSEKTVKVQLVKSLIGTRESHRATVRGLGLRRLNSVSELQDTPAVRGMINKVSYLVKVIG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.