PharMolix/UniProtQA huggingface dataset:
Protein: Y080_STAAC
Sequence: MIKRVNKLVLGISLLFLVISITAGCGMGKEAEIKKSFEKTLSMYPIKNLEDLYDKEGYRDDQFDKNDKGTWIVNSQMAIQNKGEALKIKGMLLKIDRNTRSAKGFYYTNEIKTEKYEVAQDNQKKYPVKMINNKFISTEEVKEENIKKEIENFKFFAQYSNFKDLMNYKDGDISYNPEVPSYSAQYQLTNDDYNVKQLRKRYDIPTNKAPKLLLKGTGNLKGSSVGYKKIEFTFLENKNENIYFTDSLHLEPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SACOL0080.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RS6E_METST
Sequence: MVYKVVVSDEDVTYQLELEDKDAKTVNGLKIGEEFNGGVLGLKGYKLRITGGSDKNGFPMKEDVDGTRRFKSLVNGGTGFKPTKKGLRRRKTVRGNTIADDISQINVKVSERGEQTLAEIFAEPEEEQEE
What are the official names of this protein?
30S ribosomal protein S6e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: LIPB_NEIMB
Sequence: MKIIHKGLVEYLPTFEAMKTFNAGRNADTEDELWVVEHPPVFTQGLAGKPEHLLIRDDIPVVQIDRGGQITYHGPGQLVVYTMIDFKRRKTSVRNIVSALENSIIATLAEYGIEAAADPKRPGVYVGERKIASLGLRIKNGSVYHGLALNVNMDLSPFTHINPCGYAGMEMTQIADFVQPCPTPDEVAAKLTAHLETQFTPKADNNE
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIN2_STRAM
Sequence: MSRIESVEVFVASPGRTFVTLRITTTDGVTGLGDATLNGRELAVASYLRDHVVPLLIGRDPARIEDTWQFLYKGAYWRRGPVTMTAIAAVDTALWDILGKTAGLPVHQLLGGRSRDGVLVYSHASGTDVPSLLDDVERHLELGYKAVRAQAAVPGVGGTYGVRKGRVYEPAASELPDEQPWDTEAYLDFAPRYLEAVRERFGFGFHLLHDVHHRLTPNEAARFGKSVEASRLFWMEDPTPAENQESFRLIRQHTTTPIAVGEVMNSIWDVQHLITEQLIDYVRTTVVHAGGITHLRRIFDLAALHQVRTGSHGATDLSPVSMAAAVHLDIAVPNFGIQEYMGHADETAEVFRTGVTFADGMLHPSDEPGLGVEYDEKAAERFPYQRRYLPVARRLDGSVHDW
What are the official names of this protein?
Uncharacterized protein ORF2 in unstable DNA locus.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family.
Protein: UPPP_BUCAP
Sequence: MFFFHKIVIPIIIGIIQGITEFFPVSSTGHMIIFIDWLDIKNKDTKILEIFVQLGSTISVFLFFYKKIIQILQLPMQKESNEKKNIHVLISILPTMFLGLIFYNKIKSLFNPTNVMYALILGGFFLIIAEKFKPKKPKTNSIKEINLVQSLIIGCFQTLCLYPGFSRSGASIAIATLLGFKRSVAVNFSFIISIPLIAGASVLDLIKNIQNVNMLNIPYLFSGFTISFIISFLLIKKFITILNKVSLTFFGIYRFLIAGIIYFI
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACTB_RABIT
Sequence: MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEERPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells.  Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction.  In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.  Part of the ACTR1A/ACTB filament around which the dynactin complex is built.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
What are the official names of this protein?
Actin, cytoplasmic 1, Beta-actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: OFP12_ARATH
Sequence: MPRVMWKNFHLCFPSNLTKPSSSPSGATSDDPNRPSILLINNFNLLYDDSSAAHRRLSKPLIHDVEPSSTFTASTSTAANSSSSSASYDDSDNYGFAPDDDSPPPDLTAVLASRRFFFSSPGCSNSITDSPDLRCRDNYDTATRLLTGGTAVKHYVQSPDPYNDFRRSMQEMIDAVTNAGDLRRYEFLHELLLSYLSLNAADTHKFIIRAFADILVSLLSDGHRIS
What is the function of this protein?
Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
What are the official names of this protein?
Transcription repressor OFP12, Ovate family protein 12, AtOFP12.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLND_ECOLC
Sequence: MNTLPEQYANTALPTLPGQPQNPCVWPRDELTVGGIKAHIDTFQRWLGDAFDNGISAEQLIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECILEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPIDDEFQLRGTLIDLRDETLFMRQPEAILRMFYTMVRNSAITGIYSTTLRQLRHARRHLQQPLCNIPEARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVDVWPRLPSTELIFIAALFHDIAKGRGGDHSILGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEALHQIWSRCRANYFVRHSPNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGNPLSADRHEVIRFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLELIALDQPGLLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: WTPA_PYRHO
Sequence: MRKVIPILGILLLSFIILGCLGSESREARLIIFHAGSLSIPLSQVEEKFTKYAQEKLGVKVTFQDEASGSVKAVRKVTDLKKRADIVAVADYTLIPQLMIPNYTDFYVLFATNEIVIAFTNKSKYADEMLKNPDKWYEILSRPDVSFGFSDPNQDPCGYRSVMVMKLAELYYGRPIFKELVEKTTNIYSNGTRIYAPKEIIIKDKRVIMRPKETDLVGLVESGSLDYIFIYKSVAKQHHLSYITLPDDINLGDFNKADFYGRVSITLGSTGKTIKAKPIVYGITVLKNAPNRELAIEFLRFLLGNEGRKIFEDNYQEFLSPPVAFGNVPPEIRRLVEVKD
What is the function of this protein?
Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import.  Binds tungstate and molybdate (By similarity).
What are the official names of this protein?
Molybdate/tungstate-binding protein WtpA.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CATB_PIG
Sequence: MWRLLATLSCLVLLTSARESLHFQPLSDELVNFINKQNTTWTAGHNFYNVDLSYVKKLCGTFLGGPKLPQRAAFAADMILPKSFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIRSNGRVNVEVSAEDMLTCCGDECGDGCNGGFPSGAWNFWTKKGLVSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYTPSYKEDKHFGCSSYSISRNEKEIMAEIYKNGPVEGAFTVYSDFLQYKSGVYQHVTGDLMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGIPCTPHF
What is the function of this protein?
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity).  Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity).  Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity).  Has also been implicated in tumor invasion and metastasis (By similarity).
What are the official names of this protein?
Cathepsin B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome. Melanosome. Secreted, extracellular space. Apical cell membrane; Peripheral membrane protein; Extracellular side. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Protein: RECR_PSEAE
Sequence: MSFSPLIRQLIESLRILPGVGQKSAQRMALMLLERDRSGGLKLAQALTAAMEGVGHCRQCRTLSEEELCPQCADPRRDDSLLCVVEGPLDVFAVEQTGYRGRYFVLKGHLSPLDGLGPEAIGIPELEARIRDGAFSEVILATNPTVEGEATAHYIAQLLAGRGLTLSRIAHGVPLGGELELVDGGTLAHALAGRRPIS
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: NOVO_STRNV
Sequence: MKIEAITGSEAEAFHRMGSQASHRYDEFVDLLVGAGIADGQTVVDLCCGSGELEVILSSRFPSLNLVGVDLSEDMVRIAREYAAEQGKALEFRHGDAQLLAGMEDLAGKADLVVSRNAFHRLTRLPAAFDTMLRLAKPGGAVLNCSFIHPSDFDESGFRAWVTFLNQRPWDSEMQIVWALAHHYAPRLDDYREALAQAARETPVSEQRVWIDDQGYGVPTVKCFARRAAA
What is the function of this protein?
C-methyltransferase that methylates 8-demethylnovobiocic acid to produce novobiocic acid in the novobiocin biosynthesis pathway.  Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases.
What are the official names of this protein?
8-demethylnovobiocic acid C(8)-methyltransferase, Novobiocin biosynthesis protein O.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: RK33_PAUCH
Sequence: MAKNKGVRLVITLECTECRSNSAKRSPGVSRYTTEKNRRNTTERLEIKKFCPHCNKSAIHKEIK
What are the official names of this protein?
50S ribosomal protein L33, organellar chromatophore.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, organellar chromatophore.
Protein: RS15_VIBCM
Sequence: MSLNAETKAAIVAEYARCENDTGSPEVQIALLTASINHLQGHFQAHKGDHHSRRGLLRMVSSRRKLLDYLKGKDLSRYQDLIKRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: HDRB_METMA
Sequence: MNKLSLFLGCIVPNRYPGIEKATKLCLQRLEIDACDLPGASCCPAPGVFKSFDKATWLALASRNIVLSERMERDVLTVCNGCYGSLADANMELKKDPEMKACTNSCLKEIGMEFRGTSEIRHIIEFLYKEFGPEKLKEYITTPLDLKVALHYGCHLIKPSKDRNLGDTESPVFFDELVEATGAKSVDYTDKMMCCGAGGGVRSGYADESLEMLEHKLDCICKAGVDCIVNACPFCHLQFDRGQIAVNEKFGTDYSIPVLHYSQLLGLALGFSPDQLGIEQNAVQNIEFLAKIYEISAGLS
What is the function of this protein?
Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
What are the official names of this protein?
Ferredoxin:CoB-CoM heterodisulfide reductase subunit B.
What is the protein family that this protein belongs to?
Belongs to the HdrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_STRU0
Sequence: MMLKPSIDTLLDKVPSKYSLVILQAKRAHELEAGAKATQSFKSVKSTLRALEEIESGNVVIHPDPSAKRAAVRAKIEADRLAKEEEERKIKEQIAKEKEEEGEKI
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: YQD1_CAEEL
Sequence: MEKFIDLLEFGSAEQKRKMGRPSKIPPFSHYDAYRRSDIDFFISLFSGREELYSPCKKNSDFRQKAFYIIEKKCGHFLAMRKGRNAEKLWLYLFNDFEKMIRNGGDKNDEKSKSIVPFYDCLQFLIPYLEKTDSLSKLTLTTCNAEADDQQVKAKKPKIEHELSEDKLNDDWLQKVIDTVTCQQSTSCTSIQLNSSAPSTCSAKTPNSTANLPTSEKHADIIAYVTNFLEDVPNDKLMLHKVRLFQFIEEEKSRLKEESK
What are the official names of this protein?
Uncharacterized protein C32D5.1.
Protein: KCNA6_RAT
Sequence: MRSEKSLTLAAPGEVRGPEGEQQDAGEFQEAEGGGGCCSSERLVINISGLRYETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFMEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRADGRGGSNEGSGTRMSPASRGSHEEEDEDEDSYAFPGSIPSGGLGTGGTSSFSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQPVSGGSGQNRQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPTPDLKATDNGLGKPDFAEASRERRSSYLPTPHRAYAEKRMLTEV
What is the function of this protein?
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.  Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient.  The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.  Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KNCA5, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:1993474, PubMed:15618540).  Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (Probable).  Homotetrameric channels display rapid activation and slow inactivation (PubMed:1993474).
What are the official names of this protein?
Potassium voltage-gated channel subfamily A member 6, RCK2, Voltage-gated potassium channel subunit Kv1.6, Voltage-gated potassium channel subunit Kv2.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARFK_ORYSI
Sequence: MASSQEKAKTGVLRNAAALLDEMQLMGETQGAKKVINSELWHACAGPLVCLPQRGSLVYYFPQGHSEQVAATTRKIPNSRIPNYPNLPSQLLCQVHNITLHADKDTDEVYAQMTLQPVNSETDVFPIPTLGAYTKSKHPTEYFCKNLTASDTSTHGGFSVPRRAAEKLFPQLDYSMQPPNQELIVRDLHDNMWTFRHIYRGQPKRHLLTTGWSLFVGAKRLKAGDSVLFIRDEKSQLLLGVRRATRQQTMLSSSVLSTDSMHIGVLAAAAHAASSGSSFTIYYNPRTSPSPFVIPVARYNKATYMQPSVGMRFAMMFETEESSKRRYTGTVVGISDYDPMRWPNSKWRNLQVEWDEHGYGERPERVSIWDIETPENTLVFPSSTLNSKRQCLPGYGVSVPGMEIGSANMSSFPRAQGNPYGSLQHIPAVGSELAIMLLNQSGQTLGSPLSFHQSSYSSIIQNVKQNYIPPLTVSTSACLTKQESLPSDDAQHQFHMANMQNGDLEGSEVQPVIDSISESKLNATSRDPRNTDSYTSRSTSEQNSKGEPRGKTRRSKKGLPHKTVSEKSDLSSAPSWICDNQQVGLESKLVGCDEQVNCGNIEDSSGALTQGNFVGQPHGHQVEQKGVLSPPKVESSKSPDGGKSVNSFPNQGCFSQFIDGLDWMTQPSYYQDSNVIQPAGVSENIFSSSADIPPSMIADTMETFQASCLSDCLPNSIQEFISSPDLNSLTFLSPDMQNLEVQLQHDGSNLPSTSNSFVQMSFSEESASQSANLSGLHMESTHRSINTTSCSQPMSTGGFDAGMYSKLPRLKESQILSLPEIHTNSMGTSACSMDATEYSLDRSAKPMKPPVRTYTKVQKQGSVGRSIDVTGFRNYHELRSAIACMFGLQGKLEHPGSSEWKLVYVDYENDVLLVGDDPWEEFINCVRCIRILSPSEVQQMSENGMHVLNDCIQAA
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
What are the official names of this protein?
Auxin response factor 11, OsARF5, OsMP, Protein MONOPTEROS-like.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MFR1_PHOSM
Sequence: MATAILPSTSGVIGLWDGTTDGKEGFMDYANGDTNVKQPKEYEIQVHDIRKLDPQPTLLKNGYELVDIPTVVTDEQFIESGKSDEGNAYIKDVYFAECKRIIEEVSGGVDLIIPVSFRMREQKGEKESTTKKLGNIESRYAPRPVAHLDRDTPTAITVLEETVGKEKAQELLSKHKRWAQVNVWRPIGNPATMWPLCFLNHDRIPTWNYDTHVGHVWSLNDPRVSDRGQKTYDCVVKHDDRYDYHYVSDLRPEECLVFCSFDSIPKYAMPHSAFWDNNVPADAPNRRSIEVRSLVFF
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS) (PubMed:27056201).  SQS1 is composed of a 2,8-dioxobicyclic[3. 2. 1]octane-3,4,5-tricarboxyclic acid core that is connected to two lipophilic polyketide arms (PubMed:27056201).  These initial steps feature the priming of an unusual benzoic acid starter unit onto the highly reducing polyketide synthase pks2, followed by oxaloacetate extension and product release to generate a tricarboxylic acid containing product (By similarity).  The phenylalanine ammonia lyase (PAL) M7 and the acyl-CoA ligase M9 are involved in transforming phenylalanine into benzoyl-CoA (By similarity).  The citrate synthase-like protein R3 is involved in connecting the C-alpha-carbons of the hexaketide chain and oxaloacetate to afford the tricarboxylic acid unit (By similarity).  The potential hydrolytic enzymes, M8 and M10, are in close proximity to pks2 and may participate in product release (By similarity).  On the other side, the tetraketide arm is synthesized by a the squalestatin tetraketide synthase pks1 and enzymatically esterified to the core in the last biosynthetic step, by the acetyltransferase M4 (PubMed:11251290, PubMed:15489970, PubMed:28106181).  The biosynthesis of the tetraketide must involve 3 rounds of chain extension (PubMed:11251290, PubMed:15489970, PubMed:28106181).  After the first and second rounds methyl-transfer occurs, and in all rounds of extension the ketoreductase and dehydratase are active (PubMed:11251290, PubMed:15489970, PubMed:28106181).  The enoyl reductase and C-MeT of pks1 are not active in the final round of extension (PubMed:11251290, PubMed:15489970, PubMed:28106181).  The acetyltransferase M4 appears to have a broad substrate selectivity for its acyl CoA substrate, allowing the in vitro synthesis of novel squalestatins (Probable).  The biosynthesis of SQS1 requires several oxidative steps likely performed by oxidoreductases M1, R1 and R2 (Probable).  Finally, in support of the identification of the cluster as being responsible for SQS1 production, the cluster contains a gene encoding a putative squalene synthase (SS) R6, suggesting a likely mechanism for self-resistance (Probable).
What are the official names of this protein?
Oxidoreductase R1, Squalestatin S1 biosynthesis cluster protein R1.
What is the protein family that this protein belongs to?
Belongs to the asaB hydroxylase/desaturase family.
Protein: RPSC_SYNY3
Sequence: MTKPSNDEPPLTNVRDLEAMLPLEEEDLTADSQDLEYTAVAHRQQFSTDLVRLYLQDIGRIPLLKRDEEVHIAQQVQSYLRLVEIQNRAAESDAAIDQYQTAIAVHDQLLVQLGHRPSYERWAKILGQTVATLKQTLKSGKKRWAELAGLTVEELENIEKQGITAKAHMIKANLRLVVSVAKKYQNRGLELLDLIQEGTLGLERAVEKFDPTKGYRFSTYSYWWIRQGITRAIATQSRMIRLPVHITEKLNKIKRAQRKISQEKGHTPKIDEVAEELGMTPEQVREVLTQVPRSVSLELKVGQDKDTELMDLLETDTQSPEDELMREALQNDMQEILLDLTPREQEVIALRFGFQDGVAHSLSEIGRILNLSRERVRQIEAKALQKLRHPRRRDRIRDYYENLG
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
What are the official names of this protein?
Probable RNA polymerase sigma-C factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: UREG_NITOC
Sequence: MSKQPLRVGIGGPVGSGKTTLTLSLCNALRNRYNVAVVTNDIYTEEDAQFLVRHQALAQERIIGVETGGCPHTAIREDASINLEAVAQLSQRFSDLDLILVESGGDNLAATFSPELSDLTLYVIDVAAGEKIPRKGGPGICKSDLLIINKTDLAPLVGASLEVMDRDARKMRGERPFLFSNLKSGEGLDQIIDFIERQGLFKT
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_XANOP
Sequence: MSSNEKIFSVLRAPRVSEKTARLQEISNQYVFEVSNEATKADVKAAVEQLFDVKVKAVNVVNVKGKSKSFRNRAGNRGNWRKAYVRLVDGQSIDVTAKA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: AROH_ECO57
Sequence: MNRTDELRTARIESLVTPAELALRYPVTPGVATHVTDSRRRIEKILNGEDKRLLVIIGPCSIHDLTAAMEYATRLQSLRNQYQSRLEIVMRTYFEKPRTVVGWKGLISDPDLNGSYRINHGLELARKLLLQVNELGVPTATEFLDMVTGQFIADLISWGAIGARTTESQIHREMASALSCPVGFKNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHIIMRGGKKPNYHADDIAAACDTLHEFDLPEHLVVDFSHGNCQKQHRRQLEVCEDICQQIRNGSTAIAGIMAESFLREGTQKIVGGQPLTYGQSITDPCLGWEDTERLVEKLASAVDTRF
What is the function of this protein?
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
What are the official names of this protein?
Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, DAHP synthase, Phospho-2-keto-3-deoxyheptonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class-I DAHP synthase family.
Protein: PSBM_PROMP
Sequence: METTNFGFVASLLFVGIPTIFLIGLFISTQDGEKSSFYSDSSKGKLGPKR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: TIG_RHIWR
Sequence: MQTVETLNEGLKRAYTVTIPANDVAQRVEAEIKSIAPQVRMPGFRPGKVPANLIKKMHGPAIEQDVLNKTVQDGVQQLLAEQKLRPAMQPSVELVGGDYEPGKDVALKVELEVLPDVPPPAIEGLKLERLSVEAPTDEIDAQIKRIADQQKRYDDAKDGHPAVEGDLVVLDFAGSVDGVAFEGGTGTGMSVELGSGRLIPGFEDQLEGIKKGESRSLNVTFPKDYGEKSLAGKAAVFEVTATDVRVPGETKVDDEFAQSLGLQGLDQLRELIKGQVEQELNGLTRTHMKRKLLDQLAAGHDFPVPPSMVEAEFGQIWAQLEHEATHEEDPEAARAEMEKDRDDYRAIAERRVRLGLLLSEIGQQNGVEVSAQEMQRLVQQAAMQYQPADRDRFVQYLQQDPMAAAQLRAPLYEDKVVDFLFDKAEVSDRTVTRDELEAAIEADDDTIGKGHVHGPGCGHDHHDHDHDHDHAAPAKKPAAKKAAAKPAAEEAPAAEDKPAAKKKAAVKTEEAAEAAPAPKKAPAKKAAAAKAEEAPAAAPKKAPAKKKAAAE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.