PharMolix/UniProtQA huggingface dataset:
Protein: ATG4_CRYPA
Sequence: MADVSQRTQQAVDTAMAGAAEMSRYGRRLLNMLWDPEPTNDRSLNRPVWCLGCSYTNEPTTVDRPDQDASSTVRATLPTTPSTTTLPYPLKAVPTTPPESSSSSFSSSLAYDELLEDAGWPIAFLDDFESRVWMTYRSEFEPISKSNDPRASAALSFAMRLRTLADQGGFSSDTGWGCMIRSGQSLLANTLVICQLGRDWRRGKAARQEREILARFADDPRAPYSLHNFVRHGAVACGKFPGEWFGPSATARCIQALANSNESSLRVYSTGDLPDVYEDSFMAVAKPDGETFHPTLILVGTRLGIDKINQVYWEALTATLQMPQSVGIAGGRPSASHYFIGAQRSGDAYEPGSYLFYLDPHCTRPALPFHEDVDQYTSDDINTCHTRRLRRLHVRDMDPSMLIGFLIKDEDDWDMWKDSVKYVQGKTIINVADHDPARGMPAEREAAIDEVETLKGEFV
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: ARGB_AGRRK
Sequence: MSEAQSELQASLLAKALPYMQRYENKTIVVKYGGHAMGNAELGKAFAADIALLKQSGVNPIVVHGGGPQIGAMLTKMGIESKFEGGLRVTDQKTVEIVEMVLAGSINKEIVALINQTGEWAIGLCGKDGNMVFAEKAHKTIKDPDSNIERVLDLGFVGEVVEVDRTLLDLLAKSEMIPVIAPVAPGRDGATYNINADTFAGAIAGALSATRLLFLTDVPGVLDKQGQLIKELSVAQAHALIADGTISGGMIPKVETCIDAIKAGVQGVVILNGKTAHSVLLEIFTEHGAGTLIVP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPA6L_RAT
Sequence: MPLEVVVELQIRAISCPGVFLPDKEVVYLGVYLLNQYLETDCFPSVFPIVIQQSMRFEKVFEEAMDPGAVAELLESFLTRFELVQLVSPAWEELAYYEKNTRDFLFPEPKLTSSHLGMQREVLMKTAIWFPGIAPKLEFSTRTAILECVFPCKNRFLWEERCKLQQSFSKLNGPANNRKKKPKEKNSDQLSKGTPFWGPSPQRLHLHRPTQRNPGKSFRFLGERKPPFVVRHVDSGNPFGENNLEHHSQKSRRKPKFINFDLAKKRAFSLDSLEANIKVVREPDERIVLRSQSPPPLNSGHFRKPLLNHQGDVDFHPETTVTTSQLSSPPSPLDHSLLQERFQPCSASMWQKIQERACSLLTPNRAHPKEDSISETNSIHERPSYLLRKHLLREHRYF
What are the official names of this protein?
Spermatogenesis associated 6-like protein.
What is the protein family that this protein belongs to?
Belongs to the SPATA6 family.
Protein: ARGC_CAUVN
Sequence: MANAPKVFIDGEAGTTGLQIRERLVGRTDLQLISIDPDKRKDADARAEMLNSADAVILCLPDDAAKEAVSLVSNPNTVIIDASTAYRTAEGWAYGFAELDSEQRGKIAASKRISNPGCYPTGAIALTRPLVSAGILPAELPVSYNAVSGYTGGGKAMIAQFEDESAADHTRAPYFIYGLSLSHKHVPEMQKHGGLLTRPIFTPAVGRYAQGMIVEMPLHLSTLNGAPSLADIHAALVKHYKGEAFVEVASLDEAKALTTLDPEGLNGTNRLKLFVFGSDAGGQARLVALLDNLGKGASGAAVQNLNIALGLDEAAGL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YORR_BACSU
Sequence: MTLIILEGPDCCFKSTVAAKLSKELKYPIIKGSSFELAKSGNEKLFEHFNKLADEDNVIIDRFVYSNLVYAKKFKDYSILTERQLRFIEDKIKAKAKVVYLHADPSVIKKRLRVRGDEYIEGKDIDSILELYREVMSNAGLHTYSWDTGQWSSDEIAKDIIFLVE
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YorR.
Protein: FBF1_HUMAN
Sequence: MAPKTKKGCKVTLPEKPVKLASHTRDTTGVSQMFPSSKARTKSLLGDDVFSTMAGLEEADAEVSGISEADPQALLQAMKDLDGMDADILGLKKSNSAPSKKAAKDPGKGELPNHPKPAGGAIPTKKSLPSPSSSGHQNRRFSSEDLEDPLRGLLSYDEGGITKQPPVTQSKTASDKSPSTVRDQGPSIPLTPGDTPIRKKEELLFDDGDDIMATLGFGDSPKAEKRQIGDQEGPRPARSTLDELLGRGMATKLLARPGTGEHREFKLDKKYQRPQDSEDMWGDEDFTFGAYQPTVVSSEGRQSRRQSVSRFFADSGADPKGEPGSKQSPPMASSPIQPRKGGADWLGLKDEDLDLFPASPTREAHRESSVPVTPSVPPPASQHSTPAGLPPSRAKPPTEGAGSPAKASQASKLRASKEEKEDWLSHALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQGLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRWCSQPPTGLDPSPLHLHARLALLRHMAEQDRDFLENEQFFLETLKKGSYNLTSHSA
What is the function of this protein?
Keratin-binding protein required for epithelial cell polarization.  Involved in apical junction complex (AJC) assembly via its interaction with PARD3.  Required for ciliogenesis.
What are the official names of this protein?
Fas-binding factor 1, FBF-1, Protein albatross.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cell junction. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to the apical junction complex (AJC) in epithelial cells.
Protein: TWST2_RAT
Sequence: MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
What is the function of this protein?
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C.  Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B.  Involved in postnatal glycogen storage and energy metabolism (By similarity).  Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity).
What are the official names of this protein?
Twist-related protein 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues (By similarity).
Protein: RABF1_ARATH
Sequence: MGCASSLPDRNSGTLSGLSNSENAVPADAKNLRVKLVLLGDSGVGKSCIVLRFVRGQFDATSKVTVGASFLSQTIALQDSTTVKFEIWDTAGQERYSALAPLYYRGAGVAVIVYDITSPESFKKAQYWVKELQKHGSPDIVMALVGNKADLHEKREVPTEDGMELAEKNGMFFIETSAKTADNINQLFEEIGKRLPRPAPSS
What is the function of this protein?
Endosomal protein probably involved in endocytosis.  Probably not involved in vacuolar trafficking.
What are the official names of this protein?
Ras-related protein RABF1, AtRABF1, Ras-related protein Ara-6, Ras-related protein Rab5C, AtRab5C.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Early endosome membrane. Endosome membrane. Cell membrane; Lipid-anchor. Endoplasmic reticulum.
Protein: TRPD_YERPB
Sequence: MQHLFEKLFRAESMSQEESQQLFAAIVRGELEPSQLAAVLISMKVRGETPAEIAGAAQALLADAQHFPRPDYLFADIVGTGGDGTNSINISTASAFVAASCGVKVAKHGNRSVSSRSGSSDLLAAFGIRLDMSAEQSRLALDDLGVCFLFAPQYHTGFRHAMPVRQQLKTRTLFNVLGPLINPARPPLALIGVYSPELVLPIAQTLKVLGYQRAAVVHGGGMDEVAIHAPTQVAELNNGSIESYQLTPEDFGLNRYPLAALQGGMPEENRDILARLLQGKGETAHAAAVAANVALLLKLYGQENLRHNAQQALEMIHSGQAFDRVTALAARG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RAS1_DROGR
Sequence: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLPSWNVQNEQAREVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDKDNKGRKGRKTNKPNRRFKCKML
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.  Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells.  During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.
What are the official names of this protein?
Ras-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: TOLB_BURL3
Sequence: MSLMTKLGFRALVASCLITAGSAANAQVNVLITGVGSTQFPIATANFANEANLPQQVTSIVRADLARSGKFTNIDAGSTPVPESASVDLGAWKAKGANAFVAGSVNREANGQYKVNFILYDTVKQQSLGGLSLTATDTTLRTAGHKIADYIYQKLLGVRGVFATRLSYVIKTGNRYQLQISDSDGQNARIALSSTEPIISPSWSPSGTKVAYVSFERKKPIVYIHDLPTGRRYIVSDQKGNNSAPAWSPDSNTLAVALSLTGNTQIYTVNSTGGGLRRLTQSSSIDTEPFYSPDGHWIYFTSDRGGAPQIYRMPAQGESAGAAQRVTFTGSYNTSPRISPDGKLLAYISRTGGGFKLYVQDLQSGAANAITNTNRDESPSFAANGQYLLYATQSGGRNVLAAVPSDGSAPPQILSVQGGSVREPSWGPFMQ
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ZNUA_HAEIN
Sequence: MKKLLKISAISAALLSAPMMANADVLASVKPLGFIVSSIADGVTGTQVLVPAGASPHDYNLKLSDIQKVKSADLVVWIGEDIDSFLDKPISQIERKKVITIADLADVKPLLSKAHHEHFHEDGDHDHDHKHEHKHDHKHDHDHDHDHKHEHKHDHEHHDHDHHEGLTTNWHVWYSPAISKIVAQKVADKLTAQFPDKKALIAQNLSDFNRTLAEQSEKITAQLANVKDKGFYVFHDAYGYFNDAYGLKQTGYFTINPLVAPGAKTLAHIKEEIDEHKVNCLFAEPQFTPKVIESLAKNTKVNVGQLDPIGDKVTLGKNSYATFLQSTADSYMECLAK
What is the function of this protein?
Involved in the high-affinity zinc uptake transport system.
What are the official names of this protein?
High-affinity zinc uptake system protein ZnuA.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 9 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SCRA_ARALY
Sequence: MRCSVLFVVSYVIMSLLISHVQGMEDQKWKKVCNLEGNFPGRCVGNGDEQCKRDLTEDGNNPSKCRCRFRAGRRHCRCIYCEVFGM
What is the function of this protein?
Involved in self-incompatibility.
What are the official names of this protein?
Defensin-like protein a, S locus cysteine-rich-like protein a.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYD_GLAP5
Sequence: MMRSHYCGVLNRTHVGEQVTLSGWVHRVRNLGRFIFMQIRDREGIVQVFFDEKDEALFKQASALRAEACVQIKGEVIARDTSQINKEMATGEIEVLVKELVVYNNSEVLPLDFNQNNTEEQRLKYRYLDLRRPEMAERLKTRAKITSFVRRYMDDNGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIAKCFRDEDLRADRQPEFTQIDVETTFMTAPEVRAMMEKMIRGLWLDRLNVDLGEFPQMTFAEAMRRYGSDKPDLRNPLELVDVADILKDVEFKVFSGPANDPEGRVAVIRVPNGAEITRKQIDEYTQFVGNYGAKGLAWAKVNDVNAGLEGLQSPIAKFLTDDVVKALLARVNAQNGDIIFFGADSEKVVTDAMGALRLKVGRDLGLTDLTAWKPLWVVDFPMFEKDDEGNWSAMHHPFTAPKDLSPEELVQNPKGAVANAYDMVINGYEVGGGSVRIFDPKMQQTVFGILGINEEEQKEKFGFLLDALKFGTPPHAGLAFGLDRLTMLITGTENIRDVIAFPKTTAAACLMTDAPSFGNPKALAELAIQTTVEKES
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CISY_FRAAN
Sequence: MAFFRTVTKLRSRLGQPPSLRDSVRCLQTQASSDLDLHSQLKELIPEQQERLKKLKKEHGKVQLGTITVDMVIGGMRGMTGLLWETSLLDPDEGIRFRGLSIPECQKVLPGATPGGEPLPEGLLWLLLTGKVPSRSKNMHYPVNNGVVPKFQIMCSRPLMLCLLEHIPMTQFTTGVMALQVQSEFQKAYDKGIPKSRYWEPTYEDSLSLIAQLPVVASYVYRRIYKGGRMIPVDDSLDYGGNFSHLLGFDDHKMQELMRLYVTIHSDHEGGNVSAHTGHLVASALSDPFLSFAAALNGLAGPLHGLANQEVLLWIKSVVDECGENITKDQLKDYVWKTLNSGKVVPGFGHGVLRKTDPRYTCQREFALKHLPDDPLFRLVSKLYDVVPPILTELGKVKNPWPNVDAHSGVLLNHFGLTEARYFTVLFGVSRSIGIGSQLIWDRALGLPLERPKSVTMESLESFCKKAAS
What are the official names of this protein?
Citrate synthase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RAD50_PYRAB
Sequence: MKIEEVKVYNFRSHEETVVRFRKGINLIIGQNGSGKSSLLDAILVGLYWSKKLRLRGLKKDEFRRIGGKGGTRIEIKFENDDSKYVLFRDFSRNVAYLKVQENGKWRHASEPSMESVSSYIERILPYNVFLNAIYIRQGQIDAILESDETRDKVVREILNLDKLESAYENLKRIKTNINLLIESKKSFIARTENIEELIKANEDELTKKLSEINEISSKLPPIRGELEKVRENVKELESIKGKISELKIQVEKLKGRKKGLEEKIVQIERSIEEKKAKISELEEIVKDIPKLQEKEKEYRKLKGFRDEYESKLRRLEKELSKWESELKAIEEVIKEGEKKKERAEEIREKLSEIEKRLEELKPYVEELEDAKQVQKQIERLKARLKGLSPGEVIEKLESLEKERTEIEEAIKEITTRIGQMEQEKNERMKAIEELRKAKGKCPVCGRELTEEHKKELMERYTLEIKKIEEELKRTTEEERKLRVNLRKLEIKLREFSVMRDIAEQIKELESKLKGFNLEELEQKEREFEGLNEEFNKLKGELLGLERDLKRIKALEGRRKLIEEKVRKAKEELENLHRQLRELGFESVEELNLRIQELEEFHDKYVEAKKSESELRELKNKLEKEKTELDQAFEMLADVENEIEEKEAKLKDLESKFNEEEYEEKRERLVKLEREVSSLTARLEELKKSVEQIKATLRKLKEEKEEREKAKLEIKKLEKALSKVEDLRKKIKDYKTLAKEQALNRISEIASEIFSEFTDGKYSNVIVRAEENKTKLFVVYEGKEVPLTFLSGGERIALGLAFRLALSMYLVGRIDLLILDEPTPFLDEERRRKLLDIMERHLRRISQVIMVSHDEELKDAADYVIRLRLEGGKSKVEVVS
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair.  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA.  Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
What are the official names of this protein?
DNA double-strand break repair Rad50 ATPase.
What is the protein family that this protein belongs to?
Belongs to the SMC family. RAD50 subfamily.
Protein: QUEA_BREBN
Sequence: MDVQQFDFDLPEHLIAQHPLEDRTSSRLLVLEKQTGNIVHQQFTHLIDHLQAGDVLVMNDSRVLPARLIGEKTDTGAKIEILLLKSLGEDRWETLVKPGKRMKPGTEVVFGNGLLRCVCEDVTETGGRIVRFLYEGIFYEILDQLGSMPLPPYIHAQLEDSERYQTVYAKERGSAAAPTAGLHFTKPYLEQIAAKGVQLAYVTLHVGLGTFRPVSADSVEEHVMHAEYYEIPEETVELVNQAKAEGRRVIAVGTTSCRTLETVGRANGGKLVATSGWTDIFIYPGYTFSILDGLLTNFHLPKSTLVMLVSALAGKENVMRAYKRAVEEEYRFFSFGDAMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIS12_MOUSE
Sequence: MSVDPMAYEAQFFGFTPQTCLLRIYVAFQDHLFEVMQAVEQVILKKLEDIPNCEITPVQTRKCTEKFLCFMKGRFDNLFGKMEQLILQSILCIPPNILLPEDKCQETNPFSEEKLELLQQEIKELQEKYKVELCTEQALLAELEEQKTVKAKLRETLTFFDELENIGRYQGTSNFRESLASLVQSCRKLQSIRDNVEKESRRLETQ
What is the function of this protein?
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis.  Essential for proper kinetochore microtubule attachments.
What are the official names of this protein?
Protein MIS12 homolog.
What is the protein family that this protein belongs to?
Belongs to the mis12 family.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.
Protein: DXR_LEPBJ
Sequence: MTTSVSLLGASGSVGESTLRVLRAYPQEFRLHSFSVHSNLEKAREIQKEFSPEFLCVSDSTADRTVLGNKIGKTQVLYGESALCELVREPEVQIVITAIVGSVGLRPTIAAITSGKRLGIANKETLVTFGPLVNSLIAKHKTKVVPVDSEHNALFQLLESLNRDSVEKIVLTASGGSFRDLSVEQLAYVTKEQALHHPTWNMGPKITVDSNGMINKGLEVIEAHFLFGVPYERIGVVIHPQSIAHGIVELKDGASFVYASYPDMIFPIAHSLFHPEPVPKSLRSYSAKDWGKLEFWEPDLKRYPGLGLAFEAGKAGGTAPCIFNAANEAAVELFLKDEIRFTEIPDYIWYTLDEMPIDFPTSLEEYEEVDRIARKTVLNLKARKVVSAC
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: LEXA_BRASB
Sequence: MLTRKQYELLRFINERLKEAGVPPSFDEMKDALDLRSKSGIHRLITALEERGFIRRLPNRARAIEVIKLPELSQAASNRRGFTPSVIEGNLGKVRTSTPALDDGERPVAVPVMGRIAAGTPIEALQTRSHTISVPADMLGNGDHYALEVRGDSMVDAGILDGDMALIQRNETADTGDIVVALIDDEEATLKRFRRRGASIALEPANTAYEVRILPPNRVKIQGKLVGLYRKY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: LUXS_STAA8
Sequence: MTKMNVESFNLDHTKVVAPFIRLAGTMEGLNGDVIHKYDIRFKQPNKEHMDMPGLHSLEHLMAENIRNHSDKVVDLSPMGCQTGFYVSFINHDNYDDVLNIVEATLNDVLNATEVPACNEVQCGWAASHSLEGAKTIAQAFLDKRNEWHDVFGTGK
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: CMOB_ECO27
Sequence: MIDFGNFYSLIAKNHLSHWLETLPAQIANWQREQQHGLFKQWSNAVEFLPEIKPYRLDLLHSVTAESEEPLSAGQIKRIETLMRNLMPWRKGPFSLYGVNIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFSMGVLYHRRSPLEHLWQLKDQLVNEGELVLETLVIDGDENTVLVPGDRYAQMRNVYFIPSALALKNWLKKCGFVDIRIADVSVTTTEEQRRTEWMVTESLADFLDPHDPGKTVEGYPAPKRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: UBE2K_BOVIN
Sequence: MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLSN
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains.  Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein.  Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins.  Ubiquitinates huntingtin.  May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53 (By similarity).  Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 K, E2 ubiquitin-conjugating enzyme K, Huntingtin-interacting protein 2, HIP-2, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-25 kDa, Ubiquitin-conjugating enzyme E2(25K), Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-protein ligase.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_HERA2
Sequence: MSDQRRKSAGRRKYTPRRKVCVFTAEGIVPDYKDIKRLQRMVSDRGKILPRRRTGTCAKYQRKLNVAIKRARHLALLPFVSENTRG
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: CPCE_THEVB
Sequence: MSGEGMTAVSEPVQLTVPQMLAQLQGTDTSLRYYAAWWLGKFGLETATAAERQAIVSALIAALADEADRTELGGYPLRRNAARALGKLGDRQAVPALIECLRCEDFYVREAAAIALGQLGDPRAIAPLQSLLEGGVAMARLVPGRPHLVQPVEAVIESLGHLGATEAIALIEPFLAHEMPRVQFAAARALFQLTGDAVYGDRLLAALNSEDVQLRRTALLDLGAMGYLPAAEAILQAGVEASFKLIALHGILGQQLRQAAPAEQTLSLFQGLDQLL
What is the function of this protein?
Required for the chromophorylation of the CpcA gene product.
What are the official names of this protein?
Phycocyanobilin lyase subunit alpha, Phycocyanin operon protein CpcE.
What is the protein family that this protein belongs to?
Belongs to the CpcE/RpcE/PecE family.
Protein: R27AC_ARATH
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGAKKRKKKTYTKPKKIKHKHKKVKLAVLQFYKIDGSGKVQRLRKECPNATCGAGTFMASHFDRHYCGKCGLTYVYQKEGVEA
What is the function of this protein?
Ribosomal protein RSP27a-3 is a component of the 40S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-40S ribosomal protein S27a-3.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus.