PharMolix/UniProtQA huggingface dataset:
Protein: SORD_KLEPN
Sequence: MNTWLNLKDNVIIVTGGASGIGLAIVDELLSQGAHVQMIDIHGGDRHHNGDNYHFWSTDISSATEVQQTIDAIIQRWSRIDGLVNNAGVNFPRLLVDEKAPAGRYELNEAAFEKMVNINQKGVFFMSQAVARQMVKQRAGVIVNVSSESGLEGSEGQSCYAATKAALNSFTRSWSKELGKYGIRVVGVAPGILEKTGLRTPEYEEALAWTRNITVEQLREGYTKNAIPIGRAGKLSEVADFVCYLLSARASYITGVTTNIAGGKTRG
What are the official names of this protein?
Sorbitol-6-phosphate 2-dehydrogenase, Glucitol-6-phosphate dehydrogenase, Ketosephosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: DEF_LACGA
Sequence: MILMHDITRDGNPVLRQVAKPLTFPLADEYKELADEMMQYLINSQDPKIAEKHQLRAGVGLAAPQVGKSIQMAALLVPNDKGEIIFKEVFVNPKIISESVRKACLAEGEGCLSVDKDIEGYVPRPDKLKIHYYTVDGEEKTIRLKDYPAIVASHEIDHLNGHLFYDRINKQNPFDLAEDTIVIS
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: ESRP2_HUMAN
Sequence: MTPPPPPPPPPGPDPAADPAADPCPWPGSLVVLFGATAGALGRDLGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSTQCREASGLSADSLARAEPLDKVLQQFSQLVNGDVALLGGGPYMLCTDGQQLLRQVLHPEASRKNLVLPDMFFSFYDLRREFHMQHPSTCPARDLTVATMAQGLGLETDATEDDFGVWEVKTMVAVILHLLKEPSSQLFSKPEVIKQKYETGPCSDSTVPCPYSSKADVVDSETVVRARGLPWQSSDQDVARFFKGLNVARGGVALCLNAQGRRNGEALIRFVDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGTSLEVARFLSREDQVILRLRGLPFSAGPTDVLGFLGPECPVTGGTEGLLFVRHPDGRPTGDAFALFACEELAQAALRRHKGMLGKRYIELFRSTAAEVQQVLNRYASGPLLPTLTAPLLPIPFPLAPGTGRDCVRLRGLPYTATIEDILSFLGEAAADIRPHGVHMVLNQQGRPSGDAFIQMTSAERALAAAQRCHKKVMKERYVEVVPCSTEEMSRVLMGGTLGRSGMSPPPCKLPCLSPPTYTTFQATPTLIPTETAALYPSSALLPAARVPAAPTPVAYYPGPATQLYLNYTAYYPSPPVSPTTVGYLTTPTAALASAPTSVLSQSGALVRMQGVPYTAGMKDLLSVFQAYQLPADDYTSLMPVGDPPRTVLQAPKEWVCL
What is the function of this protein?
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms.  Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2.  Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT).  Acts by directly binding specific sequences in mRNAs.  Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
What are the official names of this protein?
Epithelial splicing regulatory protein 2, RNA-binding motif protein 35B, RNA-binding protein 35B.
What is the protein family that this protein belongs to?
Belongs to the ESRP family.
Protein: PROF4_MAIZE
Sequence: MSWQAYVDEHLMCEIEGQHLSAAAIVGHDGSVWAQSESFPELKPEEVAGIIKDFDEPGTLAPTGLFVGGTKYMVIQGEPGVVIRGKKGTGGITIKKTGMSLIIGVYDEPMTPGQCNMVVERLGDYLIEQGF
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG.  Has a high affinity for poly-proline.
What are the official names of this protein?
Profilin-4, Pollen allergen Zea m 12, ZmPRO4.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SYS_HELPJ
Sequence: MIDRKLLLQDFDKVALSLKKRNHAMDDELERLREAIAHYKKQLIELEGLQAFQNKVSKEFGIKMAQKMDTSDLKKELENNKIKLNELSKSVGEAEQEMDLKLSIIPNLVDEKTPLGASEEDNIEIKKILTPRNFTFKPKEHFELAQQNGWIDFESGVKLAKSRFSVIRGFGAKIYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLYNDTIISVENLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDAMQEHMLESASEILKALELPHRFVQLCSGDLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLVHTLNGSSLAVGRTMVALMENHQQADGSIHIPKALEKYL
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_NEIM0
Sequence: MPRVKRGVTARARHQKIFALAKGYRGRRKNVYRVAKQAVMKAGQYAYRDRRQRKRQFRQLWIVRINAGARENGLSYSKFMNGLKRASIEIDRKVLADLAVFDKAAFAQLVEKAKAALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: IL21_HUMAN
Sequence: MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS
What is the function of this protein?
Cytokine with immunoregulatory activity.  May promote the transition between innate and adaptive immunity.  Induces the production of IgG(1) and IgG(3) in B-cells (By similarity).  Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers.  Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity).  May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15.  May regulate proliferation of mature B- and T-cells in response to activating stimuli.  In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704).  During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
What are the official names of this protein?
Interleukin-21, IL-21, Za11.
What is the protein family that this protein belongs to?
Belongs to the IL-15/IL-21 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLYA_THEVO
Sequence: MAYQDALSIRELAQQHNALFGDSVALIASENVMSPLAREVMISDLESRYAEGLPHHRYYQGNNFVDLIEDKTNELLSKLFKTEQTDPRPISGTNANSAAIYALAKPGDLVAVPALSGGGHISAAEFGILGMRGVRTISYPYDKNTMTVDPDEASKIIKREKPKVCLFGQSVFMFPVPLKEMKGAFDEVGCKVWYDGAHVLGLIAGRKFQDPLREGADIVTGSTHKTFPGPQHGVILGNTDSETWKSVRRAVFPGVLSNHHLNAMAALGITAAEELEFGEKYASDIIDNAKALAGELYSLGFKVLAEERGFTESHTMAVDVTQNGGGKYVAETLEASGIILNKNLLPWDDNKKSQNPSGIRIGVQEVTRTGMGKSEMKEIASLIYRAIVKKEEPSKIKEEVKDLKSSFRHVKYCYGDVDAYEYIKLI
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADH2_DROMO
Sequence: MAIANKNIIFVAGLGGIGFDTSREIVKRGPKNLVILDRIENPAAIAELKALNPKVTVTFYPYDVTVSVAETTKLLKTIFDKLKTVDLLINGAGILDDHQIERTIAVNFTGTVNTITAIMSFWDKRKGGPGGVIANVCSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANQNGAIWKVDLGTLEAIEWTKHWDSHI
What are the official names of this protein?
Alcohol dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: SYFB_CANAX
Sequence: MPTIPVDKEDLFKLLGRSYTTEEFDELCFQFGIELDEDTTEDVKGTDERPQLKIEVPANRYDMLCIEGIAQALNEFLGNTSAPNYKLSPSKPEISLTIKESTYPIRQYAASAILRNVNLDERAYDSFIALQDKLHANLCRNRTLVAIGTHDLDTLTPPFTYEALAPKDIVFKPLNQTKEINGEELMEFYEKDKNIGKFLHIIKDSPVYPVMLDANRTVASLPPIINSDHSKITLNTKNVWIDVTGTDRTKTEIVINQLVAMFSRYCKEPFEIEPVQIISEHNNETRVCPNITPRTAKAEISYINSCVGLNYSGEEISKLLKKMSLDATPSTEERDILDVKIPITRSDILHQCDIMEDVAIGYGYDNLKKTKPQAESLVAAPLPVNKVADILRLASSQAGYLEVMPLTLSSHDENFAWLKQKDDGTKAVKLENPKTIEYQVVRTTLLPGILKTVKENRKHSLPIKVFECGDIVLKNPELERGAFNQRNWAALYVGKTSGFEMVQGLLGKIMQTMRTPWLENPSKDQRRGYWIEEDKENTTFFPGRGAKIYFRNADNAEAKAIGSIGVLHPEVMNNFDIPYAASSVEINAEVFL
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHD_HALH5
Sequence: MNELEQWRKDPLVIKLMATEEVFWLNPHIDSFKSAVRKLSLHEDDVKDAEKRLDRFAPYIAKVFPGTNQAHGMIESPLVQIPSMKQSLEQKYLQPITGNLLLKCDSHLPISGSIKARGGIYEVLKHAEQLALQHGLLTVQDDYSILDSETCRDFFANYSIAVGSTGNLGLSIGIISAKLGFNVSVHMSADAKQWKKDLLRSKNVNVIEYEDDYSQAVEEGRREAEQDPTCYFVDDEQSQDLFLGYAVAAFRLKKQLAEQKITVDESHPLFVYLPCGVGGAPGGITFGLKLLFEDHVHCFFAEPTHSPSMLLGLLTGLHERISVQEIGLDNRTEADGLAVGRPSRLVSRLMKPLLSGSFTIDDDKLFTLLKELADAEGLFLEPSALAGMLGPIKLVQEGNHYLKANNLAEKMNNATHIIWGTGGSMVPEEEMMAYYRRGGTIK
What are the official names of this protein?
Probable D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: TYSY_POLNA
Sequence: MTRPIRHQYEDLMRLVATQGAFKADRTGTGTKSVFGHQMRFDLNEGFPLVTTKKVHLKSIIQELLWFLTGSSSNHWLTERGVTIWNEWARADGDLGPVYGVQWRSWPTPDGGHIDQIAEVIKTLKTNPDSRRIIVSAWNVADLDKMALMPCHALFQFYVAPATEAGGKGKLSCQLYQRSADIFLGVPFNIASYALLTHMVAQQCDLDVGDFIWTGGDCHIYSNHQEQVALQLGRAPFAYPLLHIRRKPDSIFDYQFEDFEFLDYQHHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_PARDP
Sequence: MGALMIQGTGSNVGKSLLVAGLCRAARRRGIDVAPFKPQNMSNNAAVTPDGGEIGRAQALQARAAGLAPSVHMNPVLLKPETDRAAQVVVQGRAATRAAAADYGALKARLMGAVLDSFARLRTTHELVLVEGAGSPAEVNLRARDIANMGFARAADVPVVLAGDIDRGGVIAQIVGTQAVIDPADAAMIRGFVINRFRGDPSLFDAGRRFIVERTGWPDLGLVPWFPDAVRLPAEDAVDLRRASGGGGLHIACPMLSRIANFDDLDPLAAEPAVRLSMVPPGHALPGDADLVILPGTKSTRGDLAFLREQGWDIDLAAHLRRGGRVLGICGGYQMLGRMIHDPEGHDGSPGSTPGLGLLDIETRMAPEKRLTRIAGRALGQPVEGYEIHMGRSEGPDCARPFAHIPEPDGATSPDGRVAGTYLHGLFSGDGFRAAWLGQFGAASALDYGAGVDEVLDRLAGHLEAHLDIDRLFALAR
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: FIS_SALPB
Sequence: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: KLK2_CAVPO
Sequence: VIGGQECARDSHPWQAAVYYYSDIKCGGVLVDPQWVLTAAHCINDSNQVKLGRHNLFEDEDTAQHFLVSQSVPHPDFNMSLLEPHNVLPNEDYSHDLMLLRLNQPAQITDSVQVMPLPTQEVQVGTTCRALGWGSIDPDPAHPVFPDELQCVGLEILPSKNCDDAHIANVTGTMLCAGDLAGGKDTCVGDSGGPLICDGVLQGLTSWGDSPCGVAHSPSLYTKVIEYREWIERTMADNP
What is the function of this protein?
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
What are the official names of this protein?
Glandular kallikrein, prostatic, Prostate esterase, Tissue kallikrein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Kallikrein subfamily.
Protein: SGPP1_RAT
Sequence: MSLGQRLALLAIRLQEPQRVASFQRLCGVEVPLGSPKAGEDAETEVRGAPGDPRRRPRQSGADGSPAKPDCCGAPNGVRNGLAAEPGPTGPRRAGSLRRNSLTGEEGELAKVSNLPLYYLFCFGTELGNELFYIIFFPFWIWNLDPFVGRRLVIIWVLVMYLGQCTKDIIRWPRPASPPVIKLEIFYNSEYSMPSTHAMSGTAIPIAMILLTYGRWQYPLIYGLILIPCWSSLVCLSRIYMGMHSILDVIAGFLYTILILIIFYPLVDLIDNFNQTYKYAPLIIIGLHLILGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHAAYNLGISLDPSLHTLPLAIPPLTVTLFGKAILRVVIGMLLVLFVRDIMKKVTIPLACKLFGIPCHDLRQARQHMEVELPYRYITYGTVGFSITFLIPYIFSFIGIS
What is the function of this protein?
Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P.  Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid.  Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway.  Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (By similarity).  Involved in efficient ceramide synthesis from exogenous sphingoid bases.  Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase.  In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity).  Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (By similarity).  The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity).  Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries.  Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (By similarity).  Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity).
What are the official names of this protein?
Sphingosine-1-phosphate phosphatase 1, SPPase1, Spp1, Sphingosine-1-phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the type 2 lipid phosphate phosphatase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RL11_CHLTR
Sequence: MSNKKIIKIIKLQIPGGKANPAPPIGPALGAAGVNIMGFCKEFNAATQDRPGDLLPVVITVYSDKTFSFVMKQSPVSSLIKKALGLESGSKIPNRNKVGKLTRAQITVIAEQKMKDMDVVLLESAERMVEGTARSMGVDVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: UVRB_SALPK
Sequence: MSKPFKLNSAFKPSGDQPDAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMLIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQVESTVPRYTIYPKTHYVTPRERILQAMEEIKDELADRRKVLLANNKLLEEQRLSQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGDEVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGKGKGRSTAKAGIVELDMTPKALQQKIHELEGQMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PER_DROYA
Sequence: MEGGESAESTHNTKVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAGQSLISASTSLEGGAEEKPRPSGSGCGVEQQSCRELLQDQQHGEDHSEPKATEQLQQEEGDRSGSESEAERVENAAKSEAAQSFPIPSPLSVTIVPPSMGGCAGVGHAASLDSGLAKLDKTWEAGGPGKVEPVPGVPGTAAAGTGQRGERLKEESFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSVPKDTKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKIPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHQEDLSVMKETYEMVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKSCNVFEAAPTCKLKMSEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKLELPHENELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSGTGTGSASSNYRGGSVAIQPVTLTEALLNKHNDEMEKFMLKKHRESRGRSGEKSKKSATDTLKMLEYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGVVGGSGGVVGTGGGAGVAGGGGTGTGLAGTSDGRLTMSSGAGGVVGGPGGAAAAAGVISSVGSSMPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKHPHKGGPEMPTTSQQAAAAAAQAAQAMPLQYMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFTGMTNALQIPERPLGSQSAYNKSMYTTTPPSMAKKVPGAFHSVTTPSQVQRSSSQSASVNAEPGCSASVSDPCKKEAPGSSPIPSVMGDYNSELPCSSSNPANNKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPDIEKDPKHRKLKSMSPSDSKIMEHPEEDQTQHGDG
What is the function of this protein?
Essential for biological clock functions.  Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms.  Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system.  The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex.  Light induces the degradation of TIM, which promotes elimination of PER.  Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop.  Behaves as a negative element in circadian transcriptional loop.  Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
What are the official names of this protein?
Period circadian protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization (By similarity).
Protein: ILVC_TRIL1
Sequence: MNVYYDRDCDLALIQSKKVTIVGYGSQGHAHACNLKDSGVDVTVALREGSASAVKAQNAGLKVATVAEAVASADVIMILTPDEFQSVLYRDEIEPKLKKGATLAFAHGFAIHYNQIVPRADLDVIMIAPKAPGHTVRSEYVRGGGIPDLIAVFQDASGKAREVALSYASAIGGGRTGIIETTFKDETETDLFGEQAVLCGGAVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMFEGGIANMNYSISNNAEYGEYVTGPKVINEQSRAAMKECLNNIQNGEYAKRFILEGMSNYPEMTARRRLNAAHPIEVVGGNLRAMMPWIGKNKIVDKAKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: UPPP_CALS8
Sequence: MSTFQAIFLGILQGLGEFLPISSSAHLIIFPWLFGWKEHSLVFDVALHLGTLLAVLVYFWRDYIEIIVKGITQPKSDQGKLLWFIIVATIPGAGFGYFFENIVENVFRKQYLLIAVVLAVFGFILYYVDKTAKNKFTLSNMNILQAGLIGILQAFALFPGISRSGITMTTGLLLGLKKEAAAKFSFLMSAPIILGAGVVSLLKNIHDVSSQFSSFAIGFFTSAIVGFLAIHFLLDIVRKSGFKIFAYYRFLLAALILVVFLLRI
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LUZP1_RAT
Sequence: MADIANYKDAASNRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLKIEGKDEEIKRAEDLCHTMKEKLEEEENLTRELKSEIDRLQKRMADLEKLEEALSRSKNECSQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLEKTEQSLVSELEKLKSLTLSFVNERKYLNEKEKENEKLIKELTQKLEQNKKINRDHMRNASTFLERNDLRIEDGISSTLPSKESRRKGSLDYLKQVENETRDKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLTELNKNRSLASQLEEVKLQVKKQKELGNGDIEGEDAFLLGRGRHERTKLKGHGGEVSVSKHTSREQSPQHKRERLRNRGFALNDEHCSLSNKQVSSPAFTNKRAAKASNMGVGPDSGTQETKRTEDRLAPGSSQSEGKKGREQPSVLSRYPPAAQDHTKVWRGNPKPGTESGLKGKVEKTTRTFSDSAHGSVPNDVVGKGDKTSDFSSEAHCGKRGQVPGHASQVTQVAESGCSKAIGALASSQRASSEGLSKGKKAANGLETDANFPHSKAPILSKYPYSSRSQENILQGFSVPNKEGVDHSVAVVMEDSSQHEALRCRVIKSSGREKPDSDDDLDIESLVTAKLVNTTITPEPEPKLQPNSREKVKSRGGTRTPLFENDKNAAVENDSAKSMRSSSNAVEFPDANCAGVKNQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEVVLEKQKSTPKSVTSKVTSSITIYPSDSSGPRAVPTEAPRERHTSTSNIQVGPPELTSVSNHISSPLELSIHKHDITLQLTEAERVGDGSPKNRAETVVSRSSILIKPSDSVERNSHAFPAETIRWKSHSTSSEVASSDTRHITVRNAWKSKRDLKCSEDPPTRIGRNVEATNAYTQRSSTDFLELEQPRSHPPEQGTRKVGNSGDAPELSSRRTQSSLTASEVLTRRNRIGDAVTAASWNHSSNVVSLTFLPSALICLTEDLGNTEGWEMLNLR
What are the official names of this protein?
Leucine zipper protein 1, Leucine zipper motif-containing protein.
What are the subcellular locations of this protein?
Nucleus. Note=Also detected in soma and dendrites of neurons.
Protein: PHO86_YEAST
Sequence: MAVQQRKKKEGRKSDKNAPSVPQVDASLDKPLDIDAPPTIYSVNLKPEYGTAALNLSADFIRQEQALANKYLFFHPVILVVLTIGLLIYLTPRIVFPIRNTGSVAGWFYQLARINKKVVLSGLVFTAIGASFLFTLLSRVSDSYFKSKINQLVGSKGEKVFGINLNDLVARHETKDPVVNNTHIIVYRETPIALISLAPNMTLSTDENLVMSVTTVGCRRVYVKSGIIEDLIDWAMLHSKNIRSSGKYGETMKLLIDVYSFDSTLKEILKKKGFTYIQSIRVSENRLLGGLFGVKKELWGLQFHFKAEHKD
What is the function of this protein?
Involved in the uptake of inorganic phosphate.
What are the official names of this protein?
Inorganic phosphate transporter PHO86.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.