PharMolix/UniProtQA huggingface dataset:
Protein: DPH4_KLULA
Sequence: MQRSFYEILGIESDASNIEIKRAYRAMLLETHPDKSGLNYNSNGNNTSSHSVTDIQEAYQTLIDQDLRKKYDEELAESFKKLGFHNAGDGLDLFSLDLFDYSGDEQSFSMNCPRCQITDGFQLTEDALEEHAIDYEGGGYFVLVQCSACSLWLKVLFDVMEE
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue.  Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
What are the official names of this protein?
Diphthamide biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the DPH4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS10_CAMJ8
Sequence: MERIRLKLKAYDHRVLDRTVAAIVEAVKRTGADIRGPIPMPTKIKRYTVLKSPHINKDSREQFEIRIHARMLDIVAATPDTVDSLTKLDLAPEVSVEVRAMGK
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RPOZ_NOSS1
Sequence: MLKRSKFETTQSQIMHRAEDLISAASNRYRITVQVANRAKRRRYEEFESAEDAMMKPVLRAIIEMSDELTQPEIIGEI
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RISB_HYDCU
Sequence: MKIIEGNLTAQGLKVGLVIGRFNSFIVDSLVKGAIDTIVRHGGSEDNIEQVLVPGAFEIPIVAQKMAASGKYDAIVALGAVIRGGTPHFDYVAGECVKGIGQVALNSGVPVSFGVLTVDTIDQAIERAGTKAGNKGEECTLAAIETANVLKQI
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: SMAGP_HUMAN
Sequence: MTSLLTTPSPREELMTTPILQPTEALSPEDGASTALIAVVITVVFLTLLSVVILIFFYLYKNKGSYVTYEPTEGEPSAIVQMESDLAKGSEKEEYFI
What is the function of this protein?
May play a role in epithelial cell-cell contacts.  May play a role in tumor invasiveness and metastasis formation.
What are the official names of this protein?
Small cell adhesion glycoprotein, Small transmembrane and glycosylated protein.
What is the protein family that this protein belongs to?
Belongs to the SMAGP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-pass type III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions (PubMed:15021913). Detected on cytoplasmic membranes in undifferentiated tumors (PubMed:15986429).
Protein: Y3330_BDEBA
Sequence: MNKDIFQGKIKEISGELRKKWGALTDDDIQKTKGNMEALSGLVQQKIGLSKEEASKQLSEFMTDIDKKFTSTGESASDKVNSKIDAIKNKLSH
What are the official names of this protein?
UPF0337 protein Bd3330.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: SDS23_CHAGB
Sequence: MDTNTVTKGAGNATASNSSSSLGVAVSPPMERNNSQSSIHKPSHIAAHRQSFAENQRHPPPSPRNHRHPSLTQQALLELMNHPPTNRHPNPRYAGRDWRDITVGELAVPEDVRWADLDLSVQDATMLLLKQNPTNVVLVRETPSSQEVVTTFDYSDLNAYLLVVVGLANPDEENVTLYNDISRKAQAQEDIPLREIQSLSRKEELVAVSADDYLDRAMEAFGSGIHRILITSQAGEVIGVLSQLRLVEFFWNEAVNFPAIERLYGSLLRDLQIGTQQIIAINLDRPLTDALLLMHNEGLTSVAVVDQGLNVVGNISSVDVRLLTNAASLPLLKSSCMNFISVILSERGMEHGRDSFPVFHVNPYSTLGHTVAKLVATKSHRMWVVESASPSPSAPATPLLQPSQPAGAPFAPTTGVDGPTPSGNVVMPPSPANAPAPPSPLPNQTFTTTVIPSGLPGARLSGRLTGVVSMTDILNLFAKSSGLRPSDPSEQRARRRRSSSSSVRPSLDSARASIDFRSKSAAYGWQYTSNYEYN
What is the function of this protein?
Involved in DNA replication and cell separation.
What are the official names of this protein?
Protein SDS23.
What is the protein family that this protein belongs to?
Belongs to the SDS23 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: UVRC_OCEIH
Sequence: MNENIEKKLSILPQQPGCYLMKDKNGTVIYVGKSKKLRNRVRSYFRGANDRKTQRLVQEIRDFEYMVTSSEIEALILEMNLIKKYDPRYNVMLKDDKSYPYLKITSERHPRLIVTRRLKKDKGKYFGPYPNVIAARETKKLLDRMYPLRKCNNPSGRPCLYYHMGQCKACAENPPSVKEYQEIVQEISSFLQGGFKDIRKNLAGEMQKASEALNFERAKEIRDTIQHIDATMEQQKMTLTDQMDRDIFGYSYDKGWMCVQVFFIRQGKLIERDTSVFPFFDSPEETIVSFIGRFYLHENHLKPKQVLVPVGIDNELLAKVLEIQVHIPLRGRKKELVQLAVKNAEISLNEKFQLIEKDEERTIQAIEDLGEQLNIETPHRIEAFDNSNIQGTDPVSAMIVFEDGKPNKKEYRKYKIRDVKGPDDYDTMREVVRRRYSRVLKENLPLPDLIIVDGGKGQMSAALEVLEDELGLDIPLAGLAKDDRHKTSELLYGMPPIVVPLERQSQAFYLVQRIQDEVHRFAITFHRQLRGKSLFQSELDKIPGVGEKRRKLLLSHFKSINQIKKASIEDMRKLGIPSNIAELVLNHLNSPNDDET
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA050_XENLA
Sequence: MESAKATHMTTVALVESNANPKGVQLVSTYQTNRMGDPSDLVELAQQVQKADDFIRANACNRLTVIAEQIRMLQEQARRVLEEAKRDADLHHAACNVVKKPGNIYYLYQRESGQRYFSILSPKDWGPSCPHEFLAAYKLQHDMSWTPYENIEKRDAEISIIDKLLNEQVALPSCHEPNFRGLTN
What are the official names of this protein?
Uncharacterized protein C1orf50 homolog.
Protein: SYE_METBU
Sequence: MTLSDEDKITIEKFALQNAVKYGKAPQLGAVMGKVMGLCPHLRPLSKEVGPVIQHVLDEVMKEVPEEWQARLEVIAPELIEELNTKKEPDKGLKPLDVKEGESVVMRFAPNPNGPPTLGSTRGIVVNSEYVKRYGGKFIIRFDDTDPQTKRPMLEAYDWYLEDCEWLDAKPDEVVIASDNMEVYYDYARQLLEMGHAYVCFCEGGDFKKFKDAKEPCPHRGHAPEVNLEHWDKMLAGEYEEKAAVVRIKTDIEHKDPAMRDFGAFRIVKTAHPRPEVDDKYVVWPLLDFEGAIEDHVLGMTHIIRGKDLMDSEKRQGYIYNYLGWEYPKTTHWGRVKMHEFGKFSTSGLRQSIEDGEYSGWDDPRLPTLRALRRRGIKPEAIRKFMIDMGVGETDVSLSMDTLYAENRKIIDTIANRYFFVWDPVELEVEDAVCCTVNPSLHPSEDRGVRCIDIGSKLLVCKSDVESAELGDMLRMKYLYNIEITSVSPLKCKCIGDSMEDAKSNKMRIIHWVPEDGIPVKVLAPQGEFIGMGEKQIVDELDNVVQFERFGFCRIDSVDDGVVAYFTHK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_HAEI8
Sequence: MAWIQIRLNSTNEKAEQISDFLEEIGSVSVTFMDSQDTPIFEPLPGETRLWGNTDVIALFDAETDMAEIVRLLKEAKHLDSNTAYKIEQIEDKDWEREWMDNFHPMQFGKRLWICPSWRDVPDKNAVNVMLDPGLAFGTGTHPTTALCLEWLDSLDLKNKTVIDFGCGSGILAIAALKLGAKSAVGIDIDPQAILASRDNAEQNGVVDRLQLFLSDEKPSDLKADVVVANILAGPLKELYPIISQLVKPNGNLGLSGILETQAQSVCDAYTQTFALEPVAVREEWCRITGNLKTL
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCA_BUCA5
Sequence: MIFFKKKHDKKLLLGIDLGTTYSLAATVREKSVILLLDKKKRYLLPSVVHYKKNKISVGWKALENITEDPTNTISSVKRLLGRSINFVKKKFPILPYLIEKDIHEGIFFRTNFGNITPIDVSSHILKKLKKRAVLLFNQEIDASVITVPAYFNDFQKKETKKAAVLSGINLIRLLNEPTAAAVAYGLQKLKKGIVLVYDLGGGTFDVSILNLNKGIFEVLATSGDSNLGGDDFDDALAKNIYKKSNLQNRCNDFFQTSLLQIAKSTKLKLTKYEKVEVHFFDWKGYITREEFNLIIIDFIKKTLFICSDLLEEINLSVEQIKEVIMVGGSTRIPLVHTEVSKFFKKDLLKSINPDQVVAIGAAMHVDMLFSSKNNTKNKVILLDVMPLSLGIEVMGGFVEKIIFRNTSLPISKTKEFTTYKDNQTSILIHIVQGERELVKDCISLSRFVLRDIKPQKAGLVRILVTFQVDTDGLIHVKILENYSSKEKKIIIDNNITLKNLNISQILKDSLKHSKDDYYFRVKEEKKIECVRTLEILNKSLKKHLKLISKKELKKIKYTQEKLQKSIQEDDYFSMKNNLQKLDEVSKNFFSLQLKNAIDCSSIKNILKENI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: TSAD_PELPD
Sequence: MLVLAIETSCDETAAALVDGGRRILSSVVSSQVAIHAEYGGVVPEIASRKHLEMISPVISQALAEAGVSFGDIQGVAVTRGPGLSGALLVGLSAAKAIACARGIPFVGVHHIEGHLFAPFLERPVEFPFLALVVSGGHTHLYLVEGFGRYRTLGRTLDDAAGEAFDKSAKIMGLPYPGGARIDAMAQEGSPGAIRLPRPLLADGGLNFSFSGLKTAMLNRITKHPVSIPGAEANDLCASFQQAVCDVLVAKTAAALERTGVTRLVVAGGVACNSGLRRSMQALASGLSIDLRIPAPALCGDNAAMLAVPGNHYLEQGHASELSMDVTATWDMDRVGEGRS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU2M_FELCA
Sequence: MNPPIFIIIMLTVISGTMIVVTTSHWLLVWIGFEMNLLAIIPILMKKYNPRAMEAATKYFLTQAAASMILMMWIIINLLHSGQWTVLKDLNPMASIMMTTALAMKLGLAPFHFWVPEVTQGISMSSGLILLTWQKIAPLSILYQISSTINPNLILTMSILSVMIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMMYSPTMMILNLTIYIIMTLTTFMLFMHNSTTTTASLSQTWNKTPLITSLILVLMMSLGGLPPLSGFIPKWMIIQELTKNELIMMPTLLAMTALLNLYFYMRLTYTTALTMFPSNNSMKMKWRFECTKKMTFLPPLVVMSTMLLPLAPMLSILD
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CLRN3_MOUSE
Sequence: MPTTQKTLMFLSGFLTSLGSVVVICSILATQAWITSRIFFTDAISNGTIVITYGLFRGTSAQELNEGLQDLDKNFEVLGILDNSSQKSLHLVVILLLILSLAASVLSSVFTFYNSISNPYQTFLGPMGVYTWNGLSASFVFLAMVLFVGNAESNHLSDKLSQKLYPDTTNKRTTHTYGYSFWLTLHVIFLNIVTAVIIIFYQKARYRQKQEQRKPVEYAPRDGILF
What are the official names of this protein?
Clarin-3, Transmembrane protein 12.
What is the protein family that this protein belongs to?
Belongs to the clarin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ENGB_YERPE
Sequence: MTIRNYNYHMTHFVISAPDIRHLPRDEGIEVAFAGRSNAGKSSALNTLTNQKGLARTSKTPGRTQLINLFEVVDGVRLVDLPGYGYAEVPEEMKLKWQRALGEYLQKRNCLKGLVVLMDIRHPLKDLDQQMITWAVAVGTPVLLLLTKADKLASGARKAQLNLVREAIIPFMGDIQVEAFSSLKKIGVDKLREKLDTWFSEIPPEVMAEEFDGEGE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: KDSD_FRATT
Sequence: MEISMTSHINNAVETFRLEIETLEKLKNSIDENFEKACEIILENNRDKSRVIITGMGKSGHIGKKMAATFASTGTPAFFVHPGEAGHGDFGMITKNDVLIAISNSGTSSEIMGLLPMIKHLDIPIIAITSNPKSILARNSNVTLNLHVDKEACPLNLAPTSSTTATLVLGDALAIALLKAKNFSEKDFAFSHPNGALGRKLILKVENIMRKGNEIPIVKPTDNIRKAILEISDKGVGNTLVAENNTLLGIFTDGDLRRMFEAESFNSQRAISEVMTKNPKSISKEEMAITALEKMEKYEITSLAVVDNGHNILGIVTMHDLIKLELR
What is the function of this protein?
Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs).  Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P).
What are the official names of this protein?
Arabinose 5-phosphate isomerase KdsD, API.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GutQ/KpsF subfamily.
Protein: ENGB_NEIMA
Sequence: MNLFQNAKFFTTVNHLKDLPDTPLEIAFVGRSNAGKSSAINTLTNHVRLAYVSKTPGRTQHINFFELQNGNFMVDLPGYGYAQVPEAVRAHWVNLLGDYLQQRKQLIGLVLIMDARHPLKELDIRMLDFFHTTGRPVHILLSKADKLSKNEQIKTLSQVKKLLKPYSDRQNISVQLFSSLKKQGIDEANRTVGSWFDAADAAASSPKEN
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: DTD_LARHH
Sequence: MRVLLQRVGQASVEVDRQVVGEIGRGLLLLVGVEPEDSAADIDWLVRKIVNLRVFSDAEGRMNRSVLEDGGEVLAVSQFTLFASCRKGNRPSWSRAAPPELARCRFDQFVAAMSEALQRPVPTGVFGADMQVALVNDGPVTLWLDSRQPE
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO_PROM5
Sequence: MTSKKFSDKKNNYDAILVGAGIMSGTLALLLTEILPELKILIIEKLKIPGSESSGAFNNAGTGHAANCELNYTPLDDYGHLKIEKALSINRSFEKSMSLWASLYSSQKIDIKKFLKFIPHISFVTGSENVSFLKKRFKKMTEYKEFEDMEFSSSFNQISSWAPLITKSRNPLDEVAATRVKRGTDINFEVLTREYLKYISKNKNVEISYETELNDLKKTSNKEWELNISMEGRKVNLKTSYVFLGAGGKTINYLQKSNIPEAKVYGGFPVSGKWLICEENSLTEKHNAKVYGRADIGSPPMSVPHLDTRWIEGKKFLLYGPFAGFTTKFLKQGSYLDLFNSLKKNNLLSMLDVGIKNNDLINYLFSQSIKSHKSRVENLRNMMPSADPSNWYLENAGQRVQIIKKTKKGGSLKFGTEIVNAADGSLSALLGASPGASTAVSIMIEVLKKSCLFTLDKSILEQKISHLLYESELKNQNENDFLENLKKRNNSILGFHP
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: NAMT1_ORYSJ
Sequence: MGGGGDGELSPAEARLAMMELANMISVPMALTAVIRLGVPAKLWAGGANAPLAAADLLPAGHPDPSVLERLLRLLASRGVFSEHTGSSSPSPRRFSLTAVGRTLVPGGGGSPSGSGASYADYVLQHHQDALVRAWPLLHEAVLDPSGPEPFARANAGVPAYAYYGKDREANEVMLRAMTGVSEPFMEALLEGYGDGGFEGVSTLVDVGGSSGACLEMIMRRVRTIRDGVNFDLPDVVAAAPPIPGVRHVGGDMFKSIPSGDAIFMKWVLTTWTNEECTAILSNCHKALPGGGKVIACEPVVPDTTDGSTRTRALLENDIFVMATYRTQGRERSEEEFRHLGLAAGFASFRAIYLDPFYAVLEYTK
What is the function of this protein?
Involved in nicotinate detoxification in planta (PubMed:28533213).  Catalyzes the conversion of nicotinate to N-methylnicotinate, which is a detoxified form of endogenous nicotinate in planta (PubMed:28533213).
What are the official names of this protein?
Nicotinate N-methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: YGL2_STRVR
Sequence: MSRRRTLGPKKKIALLVSAVTVAGGGAFVMASTSNASPPTTKSAAESTACLGLATALGNNEKFIADQQANPDAQSEARIANRQAVIEEIKRKQEASGCTVGESAQDSQTAQPSQPAQGGEQAGGGEQAGGAEEAGGAQASQPAESAPAENAGGGAAASGQQVCNGSTVTLSGEGGAPAASSNQFPAGTKLKVTNLDNNKSTTVEVTSVSGSCVLLNNAAFEQVREAGKFLIRRAVIEKVG
What are the official names of this protein?
Uncharacterized 23.9 kDa protein in glnII region, ORF2.
Protein: MYD88_MACMU
Sequence: MAAGGPGTEPAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLEIRQLETHADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP
What is the function of this protein?
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.  Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Increases IL-8 transcription.  Involved in IL-18-mediated signaling pathway.  Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes.  Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity).  MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
What are the official names of this protein?
Myeloid differentiation primary response protein MyD88.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYT_METPE
Sequence: MRLLLIHSDYIEYEAQKKTKMAEADPVPKDGMTEALTVFTAVEAVDEEDIDDVVAQSVAEIEKTATQLAVKNLLIYPYAHLSSDLSSPEAAVAALSAIERRLNETGRYEVKRAPFGWYKKFKLSCKGHPLSELSKTIVPGAGAAVKEKKEVTHEFFVMTPDGERHETGEFLEGRFGALVKKEIGIAEPVGGEPIHVDLMRSKELVDYEPASDVGNLRWLPRGKIVRDLLADYVLHMVLEYGGSPVETPVMYDLGDKAIYEHADKFGERQYRFKSGNRNMMLRFAACFGMFSIMRDMHISPNTLPIKMYELSTYSFRHEQRGEVIGLKRLRAFTMPDMHSLCLDMEGALHCFEEQLRLGWKSGEDFETELVGVFRCTRGFYEKYENWVKSIVAESRVPMLIEILSDRVHYWIAKVDLAAIDGQGRPIENPTVQIDVESSTRFDIKYHLDGEVVHPPILHCSPTGSIERVICALLENTANQSVPQLPAWLAPTQVRLIPVAERHTSFADELCTRLNKAQIRTDLDDREESVGKKVREAGMDWVPYVIVIGDAEMETGKLTVTIRKLSEPRVPHKEQLDVEELITLVRTSTDGMPFRPLYTTRNLSKKPRYI
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSRA_FERNB
Sequence: MLVLSRKIGESIIIGDNIEVKVLKIESGTVKIGIIAPTNVKIYRQEIYQTVAEQNKKTISEIVNSPDDLKHLKEVLKNVNKNR
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWR1_KLULA
Sequence: MPEVRDWRQLAKTRLEYELLTNELFHLWEFTSLVEYDPLFRNTSNSFKTFLQERGLDVESSLEQDDMKESNASRRLKRRNVISGTADSSSDKNNIWGQVMPLVDQEYSELQEKLRASVCGRRGRKRTQQVASVPAESEEDVAVPRPNKKRQTVVTAQGSAQNKLNTPVVSSPKKSLKQTADKKSKLNKRDSSTNDISVESEDPPVKDITNTGQGKSKARLKSSKAKSKKRAVKSQTELVRKQSPEIKNESKRTKADPTHTNDDGNDNRKTNNKSKNIINNNESGLKTSLNTTGDIIDDEEYYFTSSSEDDDNEKPRTALQKKSLPNRLKVKLHVNAPRQTITNPLHVLKPEYADVHSFLQSYKSLDEDVSLEEYDSYIKEQRKTAKLIRIGFERGAIKYDPQTDSLQSLSLRDVMPPSNAAEPISVYYKEQSKHTFQDHLVNQGIVLSKSFQDSRRSQIAKARRVAQIIESHFKHIAGAEERKLKEEEKRKKNLARFAMQAVKKRWTMAEKAYKVLKKDELDQLERIQGKQHLTEMLEQSTQLLGAQLNQLDSCTYPSEASDASSEFSANEESDGNSDIDDEMMSTSSCDSDKEGNTERIGNDMELSVEELRSKYAQLNKINDFGNETSKSAADESIFDEASDSVSDSMEDSLSSSESETEDADASAQEDTPGLSALLGNIDENEEDVEADVNFDADSSSDDGLDGDSSGAENNSKTEELPSPPKSDNELKDEKAETTESVTSPAAADPLAVSDVPVPSLLRGTLRIYQKQGLNWLASLYNNKTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGSPQQRREKRKGWNKPDAFHVCITSYQLVVHDQHSFKRKKWQYMILDEAHNIKNFRSTRWQALLNFNTERRLLLTGTPLQNNLAELWSLLYFLMPQTALENGKVSGFADLDAFQQWFGRPVDKIVETGENYEQDEETKKTVSKLHQVLRPYLLRRLKADVEKQMPGKYEHIIYCRLSKRQRFLYDDFMSRAQTKETLASGNFMSIINCLMQLRKVCNHPDLFEVRPILTSFCIEDSVSKSYCDLNNYVYNRLHENQFETSVDLSNLNFQFTSNDKTLSTNHSEKISELQCVQPILKEISRLKQLNENDSPVTQPDFQDLNQYYSYAKHNKINEIIGQLEHLNYMNNLRCNRRPMYGSNIVKLLTVGPKKFIDCELTQESIKPLETRLLEGKETIEKFAVITPPVVTLDIRERAVGVDDNNKRFEESVKHHLVSQMRSLENPFHQLQTKLSVAFPDKSLLQYDCGKLQKLAQLLQNLKDNGHRALIFTQMTKVLDILEQFLNFHGYLYMRLDGATKIEDRQILTERFNSDPRITVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYRFVSDHTIESNILKKANQKRHLDNVVIQTGDFTTDYFTKLSVKDLLGAEAPEDIPDDKPLLQDQKNLNKLLAQAEDEDDAKAAKSALREVNVDNEDFQEGSVAAQDGNSDNENNEDSEDEYGGTSHVEEYMVRFIANGFYY
What is the function of this protein?
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
What are the official names of this protein?
Helicase SWR1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: NSRR_KLEP3
Sequence: MQLTSFTDYGLRALIYMASLPEGRMTSISEVTEVYGVSRNHMVKIINQLSRMGYVTAVRGKNGGIRLGKPAGQIRVGDVVRDLEPLSLVNCSSEFCHITPACRLKQALAEAAQSFLKELDNYTLADLVEKNQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: GCH1_EUGGR
Sequence: FSMCEHHMLPFWGKVHIAYIPKGKVLGLSKLARVAEMYARRLQVQERLTRQIASAIERSIQPLGVAVVVDCCHMCMVMRG
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: RL10_PETMO
Sequence: MLTKERKKSLIDSFIYALESSPVILFVDFSGMSVLESNDFRLELYKNFGKDVVFTVYRTSLLKTAVKLANKELEDFEKFFEGSTGVIYAEESDPVDVLKAVKKFSESHNNKPFIKGGVLEGKIFDAAKAEEYAKLPSKQELYATVVRSLNSPISGLVNALSGNLRKVVYVINAIKEKK
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RL10_AZOVD
Sequence: MAIKLEDKKAIVAEVNEAAKAALSAVVADARGVTVGAMTGLRKEAREAGVYVRVVRNTLARRAVAGTQFEILNDAFKGPTLIAFSNEHPGAAARIFKEFAKGQDKFEIKAAAFEGQFLAANQIDVLATLPTYNEAVAQLMSVIQGATSKLARTLAAIRDQKEGAAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RL33_CROS8
Sequence: MAKGIREKIKLVSSAGTGHFYTTTKNKRTKPEKLELKKFDPVVRQHVLYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.