PharMolix/UniProtQA huggingface dataset:
Protein: PSBD_PEA
Sequence: MTIALGKFTKDQNDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFAVGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDLTRWCQLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMATQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: ISL1_CHICK
Sequence: MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDETCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARAKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA
What is the function of this protein?
Acts as a transcriptional regulator (PubMed:7528105).  Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes.  Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation.  Binds to insulin gene enhancer sequences (By similarity).  Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (PubMed:7528105).  Acts in conjunction with LHX1, LHX3 and ISL2 (PubMed:7528105).  Binds to insulin gene enhancer sequences (By similarity).  Essential for heart development (By similarity).
What are the official names of this protein?
Insulin gene enhancer protein ISL-1, Islet-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: PBPA_CLOPE
Sequence: MTERKREHKDRKQNKNSPKNQSKVTKFLKWFFIGILLLGITAVTVVGIYVLSIIRSSPELDVQAIQSLNQPSILYDDQGNFMDNVITREQRYVVKSEEIPDNLKKAFVAIEDERFYEHKGIDIKRIFGVIASNIKGKLSGSNTVQGASTITQQLIKNAVLTNEVSYERKIKEMYLALELEKHLSKDEILTTYLNTIPMGGYQYGVSAAAQRFFSKNVSDLNLVECAYLGGLTQAPTSYDGLSEANKENPSRYLNRTKSVLFKMHELGYISSEQYNDAINEIDTNGIKFTPNNKLSKTNFEWFTRPAITQVKQDLMDKYKYTQEEVDKLIANGGLKIYTSMDRNLQNNVQKVLDDPNNYKAITNNPNEKNEDGVYKLQASATIIDYKTGHVKALVGGRGEQPAMSHNRAYYDLKSIGSATKPLTVYGPAIDLGLGGAGSVVNDSPLSNKELSSTGYKDQPKNEYNSYRGPLTFREAIKISSNLAAIKVANEVGVSNSIAYGEKLGLVYGPHSRGISTTALGQFQNDPNNPDGGNTYTLASAFGVFGNNGVKTNAKLYTKVLDSHGNVILDTSTPEETKIFSPQASYIVYDMLKDQVESGSAKSAKFGNIPVAGKTGTTTGDKDYLFAGLTPYYSAAIWIGYDKPREMRTSSGTVTSPIFGKIMGLAHKDLQYKEVDNLVE
What is the function of this protein?
Cell wall formation.  Synthesis of cross-linked peptidoglycan from the lipid intermediates.  The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
What are the official names of this protein?
Penicillin-binding protein 1A, PBP1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transpeptidase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: TR43B_HUMAN
Sequence: MDSDFSHAFQKELTCVICLNYLVDPVTICCGHSFCRPCLCLSWEEAQSPANCPACREPSPKMDFKTNILLKNLVTIARKASLWQFLSSEKQICGTHRQTKKMFCDMDKSLLCLLCSNSQEHGAHKHYPIEEAAEEDREKLLKQMRILWKKIQENQRNLYEERRTAFLLRGDVVLRAQMIRNEYRKLHPVLHKEEKQHLERLNKEYQEIFQQLQRSWVKMDQKSKHLKEMYQELMEMCHKPEVELLQDLGDIVARSESVLLHMPQPVNPELTAGPITGLVYRLNRFRVEISFHFEVTNHNIRLFEDVRSWMFRRGPLNSDRSDYFAAWGARVFSFGKHYWELDVDNSCDWALGVCNNSWIRKNSTMVNSEDIFLLLCLKVDNHFNLLTTSPVFPHYIEKPLGRVGVFLDFESGSVSFLNVTKSSLIWSYPAGSLTFPVRPFFYTGHR
What are the official names of this protein?
Tripartite motif-containing protein 43B.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
Protein: TRPD_METBU
Sequence: MKYYLQKLIDGHDLSMVESEAAMGQILESATDAQVGAFVMGMKMKGETSDEVAGFAKGMLNVANMIRPKVDGILVDTCGTGGDRHNTINISTAAAIVAAAAGVTVAKHGNHSFTSLSGSADVFKELGVKIDLEPDLVKSSIEDIGIGFMLAPKFHPAMKRMVGPRKELAVRTMFNILGPLTNPTGAKAQVIGVFDKDLCNLMAEVLKKLGKEHVMVFHGDGMDEISTLSETFVAELKDGIISNYTLTPEELGVARAKATDIVGGTPEENAHDLLYILNGEKGAKRDIVVVNAAAAIYVAGLAISIKDAIPLAEEAIDSRKALNKLKELVEFTSGNKVDNEAFNTGQSLRNEVC
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RL6_LEPIC
Sequence: MSRIGKAEIKLPDKVEVKQENANIKVKGPLGELFTPIFEGISVKTENGIVKLERSNEDQKVVALHGLTRALLMNCVKGVSQGWEKNLEITGVGYRAQKRGEDLVMSLGFSHEVVYKAPKGIKIDVQEQLKIKVSGIDKQLVGQVAADIRSKRPPEPYKGKGIKYAEEFIKKKAGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SURA_YERPS
Sequence: MKNWRTLILGLVICANTAFAAPQEVDKVAAVVDNGVVLQSDIDGLLQSVKMNAQQSGQQVPDDSTLRHQILERLIMDNIQLQMAKKMGITITDQALDKAIADIAAQNRMTLAQMRSRLAADGLSYDTYREQIRKEMLTSEVRNNEVRRRITILPQEVESLAKQMGNQVSGDTELNLSHILIPLPENPTQQQVDQAEDLANKLVADIKGGADFGKLAIANSADSQALKGGQMGWGKLQELPSLFAERLQSAHKGEIVGPIRSGVGFHILKVNDMRGADQTISVTEVNARHILLKPSPMMTDEQARAKLEAAAAEIKSGKTSFATIAKEISQDPGSAMQGGELGWASPDIYDPAFRDALMKLKKGEISAPVHSSFGWHLIQLVDTRQVDKTDAAQKERAYRMLFNRKFAEEAQTWMQEQRAAAYVKILDGSNAQPQ
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: RS10_THEVO
Sequence: MASYKARISLSGTEHKIVDMVCSEIKEIASRTGVEIHGPMPLPTKKLVVPVRKSPDGEGTNTWDHWEMRIHKRLIDVDADERTLRQLMRIPIPDGVQIEIQIKS
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: COPZ_ARCFU
Sequence: MMRCPECSTEGWRVLPLTVGAHVKEGLWSKIKGDFYFCSLESCEVVYFNEQTVFRKGELKTRVGVKEREEPKPVCYCNRVTEKMLLEAAEKFGKEKAVEITGAGKGKWCVVTNPSGRCCHWHLERLGFPVGGEKKAAKRVEIKLDGLTCMGCVSAVKAALEEAGANVVEIGLDRAVVEVDEEAELQKLVEAVEGAGYSARLEKR
What is the function of this protein?
Chaperone that serves for the intracellular sequestration and transport of Cu(+).  Delivers Cu(+) directly to the transmembrane transport sites of copper-exporting P-type ATPase A (CopA).  Probably has a redox function due to the presence of a 2Fe-2S cluster and could reduce Cu(2+) to Cu(+).
What are the official names of this protein?
Copper chaperone CopZ.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: USOM5_ACRMI
Sequence: MGAARFLVQVAIFLLVKPARSAPAPMWKGNSTARKSCSQASINNCSCRCELSPASTTANAVSALEDKIDQVIALANRTTPRHSAPVASISSCKEQFDKNNSSPSQVYELTFGSQVVPVYCHMGNFGCGNGGWTLAMKMDGTKTTFHYDSLVWSAQSSYNPAAGKTGFDMLETKLPTYWSTPFDKVCLGMRLGQQLNFVVLNMTANSLFSLIADGLYRATSLGRNTWKSLIGAQASLQRNSIEKGSTPGLVVIGMPG
What are the official names of this protein?
Uncharacterized skeletal organic matrix protein 5, Uncharacterized SOMP-5.
What are the subcellular locations of this protein?
Secreted.
Protein: FABH_STAAN
Sequence: MNVGIKGFGAYAPEKIIDNAYFEQFLDTSDEWISKMTGIKERHWADDDQDTSDLAYEASVKAIADAGIQPEDIDMIIVATATGDMPFPTVANMLQERLGTGKVASMDQLAACSGFMYSMITAKQYVQSGDYHNILVVGADKLSKITDLTDRSTAVLFGDGAGAVIIGEVSEGRGIISYEMGSDGTGGKHLYLDKDTGKLKMNGREVFKFAVRIMGDASTRVVEKANLTSDDIDLFIPHQANIRIMESARERLGISKDKMSVSVNKYGNTSAASIPLSIDQELKNGKLKDDDTIVLVGFGGGLTWGAMTIKWGK
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Has some substrate preference for butyryl- and isobutyryl-CoA.  Its substrate specificity determines the biosynthesis of branched-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III, SaFabH.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_SYMTH
Sequence: MSKAAEVIEIIKGMTALELKELKELFEETFGVTAAAPVAVAAAPAAGAAAAAPAAEEKTEFDVILKNPGANKIAVIKVVRELTGLGLKEAKDLVDGAPKPVKEKVSKADADAAAEKLKEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: TRPC_GLOVI
Sequence: MKIRRRPEQPPVAVGPLQFQLQGADVEPGNILEKIVWAKEQELDRWRERLPLAKLRARTASAPEVRNFLGALRRSPHPVAVIAEVKKASPSRGVLRSDFDPVALAQAYTRGGADAISVLTDEAFFQGSFTNLSRIREQVPLPLLCKEFILGPYQIYLARAHGADAVLLIAAILSDTDLAYLMRVADQLGMAALVEVHDLEELDRVLALEGVALVGINNRNLLDFEVHLETTETLLTERGERLAEWGITVVSESGIYQGADLARVRKAGARAVLVGESLLREADPAQAVGRLVEGV
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: LIPA_AJECH
Sequence: MATSAGKLRTLYSAHSSLSSLPPSARPTLQLATLRSYATTTPHDSPIGNTSNTPPTVKRPATAFKDKLNAGPAFSDFVSGKKDEPLDPAEAYALKTALVGPPGRKKEITRLPPWLKTPIPDSSNYKRIKNDLRGLNLHTVCEEARCPNIADCWGGSSKSAATATIMLMGDTCTRGCRFCSVKTSNKPPPLDPHEPDNTAEALSRWGLGYVVLTTVDRDDLADGGARHCAETVMKIKQKAPNILVECLTGDYAGDLDMVALVANSGLDVFAHNVETVEALTPFVRDRRASFQQSLRVLKAAKAAKPELITKTSLMLGLGETEAQLWDALRALRAINVDVVTFGQYMRPTKRHMAVHEYVRPDVFDLWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRKGGNAGSVNEKVTTSENVKKLVAGEAMR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HIBC1_ARATH
Sequence: MAVEMASQSQVLVEEKSSVRILTLNRPKQLNALSFHMISRLLQLFLAFEEDPSVKLVILKGHGRAFCAGGDVAAVVRDINQGNWRLGANYFSSEYMLNYVMATYSKAQVSILNGIVMGGGAGVSVHGRFRIATENTVFAMPETALGLFPDVGASYFLSRLPGFFGEYVGLTGARLDGAEMLACGLATHFVPSTRLTALEADLCRINSNDPTFASTILDAYTQHPRLKQQSAYRRLDVIDRCFSRRTVEEIISALEREATQEADGWISATIQALKKGSPASLKISLRSIREGRLQGVGQCLIREYRMVCHVMKGEISKDFVEGCRAILVDKDKNPKWEPRRLEDMKDSMVEQYFERVEREDDLKLPPRNNLPALGIAKL
What is the function of this protein?
Involved in valine catabolism.  May be indirectly involved in benzoic acid biosynthesis and in cold signaling and cold tolerance.
What are the official names of this protein?
3-hydroxyisobutyryl-CoA hydrolase 1, CoA-thioester hydrolase CHY1.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: DNLJ_MYCAP
Sequence: MQKEEAKELIKSLVEKINQWNYEYYQLNKPSVSDLEYDKALLELEKLEKEHPDLILSNSPTFRIGSFASEKFTKFVYQKPMLSLAKAYNYDDINSFINNISKIVPTENINFNIEPKIDGLSIALRYKQGKLVKAATRGDGSEGEDVTENIYQIKSIPKLINYFNDLEVRGEVFITKNDFKKINESNNFANARNAASGTLRQLDANIVAERNLSAFLYEIVEPEKHGIYYQHEALEFMKNLDFPTNPFSKVVEIEELEESISDFAEIKNKLDYDADGLVIKLNDLQMWDKLGKTSKFPKHSIAFKYDVEVASSRITDILTSVGRTGKITYIANILPVLLNQTTVKAATLHNHNFIKDMNININDEVNIIKAGEIIPKVISLKEEKNYVDYYKKATNCPSCGSQLVEFEGIVDQFCTNDECPDKNINNIYHFASRNCLNIVGLGLSTVKDFYPKFIKNIKDIFDLHKYRAELIKLPRYRDLKVDNILNSIESAKNKKFSKVIFALGIKHIGQRAAKLIADNYANFAELLDDHNLLKLQNTKNIGPKIIESLIEFISSPANQDLLAFLDAIFNYEGKAKVISTILSGYTFVITGVLSEPRSHFVKLIEEHSGNVSSAISSKTSYLLAGSDAGSKLEKAYKTGTKVINEEQFYDLIKQ
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: Y181_CAMC1
Sequence: MASEHSFDISAEVDMMEVKNALETAKKEIAARYDFKGLAAEVELNEKEKFITLLSSSDNKIDALKDIVISKLIKRNIPPVAITETKREPASGGNLKATLKLNDTLDSENSKKITKAIKDSKIKVSAQIRGEEIRVTSKSIDDLQECIKLVRGLNLELPISFKNLK
What are the official names of this protein?
UPF0234 protein Ccon26_01810.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: FDHE_ECO55
Sequence: MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNLYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLPRDKHWQKLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCGSMPVSSMVQIGTTQGLRYLHCNLCETEWHVVRVKCSNCEQSGKLHYWSLDDEQAAIKAESCDDCGTYLKILYQEKEPKVEAVADDLASLVLDARMEQEGYARSSINPFLFPGEGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCD15_DANRE
Sequence: MSRLSLTRSPVSPLAAQGIPLPAQLTKANAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTCKLLLPDDFKDFNLLYEEARYYQLSPMIKELERWKQEREQRRLANPCDCLVVRVTPDLGERIALSGEKVLIEEIFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVLERLFQKGFNVAASCGGGVDSSQFSEYVLCREDRRSHNTNTPIRIKQEPLD
What is the function of this protein?
During embryonic development, interferes with neural crest formation.  Inhibits AP2 transcriptional activity by interaction with its activation domain.
What are the official names of this protein?
BTB/POZ domain-containing protein kctd15, Potassium channel tetramerization domain-containing protein 15.
What are the subcellular locations of this protein?
Nucleus.
Protein: NRDR_PROMS
Sequence: MQCPTCQNTDSRVLESRSADSGKSVRRRRECLNCSFRFTTYERVETMPVSVLKKDGGRELFDKQKLFTGISRACEKTNFSSEEIINFVDGIESQIVQDSNKDIKSSHIGELILKNLRKENEVAYIRYASVYRKFNGVKDFISTLESLKGSSKNQLASIS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PURR_GLAP5
Sequence: MATIKDVAKLVGVSTTTVSHVINKTRFVAEDTTKAVWEAIASLNYSPSAVARSLKVNTTKSIGMIITTSEAPYFAEIVLAVEEYCYRQGYSLFLCNTQNDAEKVQNHLDMLIKKRVDGILVMCSEYTENSLALFNGTNVPMVVMDWGPNDGKSDRIIDHCLDGGYMATKHLIDNGHRDIAIIAGYLYKTTAKARYDGFVKAMTEAGLLIRKEWIFENDFQPEGGYESMNNLLNQDKLPTAVICGCDAMALGVISAITEKGLSVPQDISVIGYDNIHSSRFYAPPLTTIHQSKTRLGQMAIDTLLERIQQHNEQPSEPVTPKVLEFYPELVVRSSVRNLNQ
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: ILVD2_ACIAD
Sequence: MSKDNIRQYSAPVYDGIENAPARSMMRAVGFQDKDFNRPFIGIASTWANVTPCNMHIDGLAREAEHGVNQASGKGIIFNTITISDGISNGTEGMKYSLVSREIIADSIEAVIGCQGYDGVIAIGGCDKNMPGCIMGLARLNRPGLFIYGGTIQPGEGHTDMISVFEAVGQYAKGEINAIQVKQIEEVALPGPGSCGGMYTANTMASAIEALGMSLPGSSAQDAISEEKRQDCHRAGEAVMNLLRLDIRPRDIMTKAAFENAIKVVIALGGSTNAVLHLIAMAHTAEVKLDLDDFVRIGQETPVVADLRPSGKYLMSELIKIGGIQPLMKRMLERGMLDGSCLTVTGKTLAENLAEVEDYPADQQIILPFEQPVKKDSHLVILKGNLSPTGAVAKITGKEGLYFEGPARVFEGEEGAMRGILDGEVQEGEVVVIRGEGPKGGPGMREMLKPTSAIIGKGLGQSVALITDGRFSGGSHGFVIGHVTPEAYEGGPIGLVENGDKISINAETREITLHISNEEMSLRRAKWQKPEPKYKSGALAKFAKLAAGADKGAVTDLNLDV
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase 2, DAD 2.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: DRS7B_XENLA
Sequence: MDLTSWAIFPLLLASIGVYGLYKLLQKLRSGAYLQAAVVVITGATSGLGKECAKVFYAAGSHLVLCGRDEERLKDLVQELNNMRLKSTQLHKPHMVIFDLSDVEAVNTAAKEILHLAGRVDILINNAGISYRGTILDTKVSVDRMVMDTNYFGPVALTKALLPSMIKNRRGHVVVISSVQGKISIPFRSAYSASKHATQAFFDCLRAEMSPYDIDVTVVNPGYIKTNLSLNAVTGDGSGYGVMDKNTADGRTPEEVAQTVLRAVGERRKELLVAGLVPTLAVYLRTLAPTLFFSIMSARAKKRTKAKGFITNSNLKAKITVCI
What is the function of this protein?
Putative oxidoreductase.
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 7B, Short-chain dehydrogenase/reductase family 32C member 1, Protein SDR32C1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: GLMS_MYCLE
Sequence: MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSGIALINGSAKSGNLTVRRRAGRLSNLESVLAEMVPASLAGNVGLGHIRWATHGRPTDRNAHPHRDATGKIAVVHNGIIENFPSLRHELEIAGVEFVSDTDTEVAVHLVAQAYCAGETAGDFVGSVLAVLRRLQGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMFVGSDVAAFIEHTRQAVELGQDQAVVITADGYRISDFDGNDDAVNARTFHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTLLGHFTGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGLLAKYTIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQVAANYLLGLALAQARGTKYPDEVQREYRELEAMPDLVARVIAGMGPVADLAYRFAQSTTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEENLPVIVVMPSPKGSAMLHAKLLSNIREIQTRGAVTIVIAEEGDDTVRLYADHLIELPAVSTLLQPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_BACSU
Sequence: MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKPVIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLSSLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLIDGKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_PROMH
Sequence: MHCPFCTAVDTKVIDSRLVGDGSQVRRRRQCLVCHERFTTFEVAELVMPRVVKSDEIREPFDEEKLRRGMLKALEKRPVSSDDVEAAINHIKSQLRATGEREIPSKQIGNFVMEQLKKLDKVAYIRFASVYRSFEDVRDFGEEIAKLQD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: MD341_PENRW
Sequence: MAFKFNWSPLIADASFYTRAQDLLTAALNKSPKPPIIVGDITVTELNLGSIPPELEILEIGDLAEDRFRGIFKMSYTGDAFLTLKTRVQANPLNTYLITRPSFASPLPLAAATPLTIPLQITLSDFKLSGFVILVFSEQKGITLVFRNDPLESLKVSSTFDSIPFVRDFLQGEIEAQLRILFIDELPAIIHRLSLQLWDPEYRAEEIQNQMNTTLTPTKGPGHDPLVTPPQDPVDSLGNVLDESDIASLSLDSAAETHSLFSQKNLLSLATLTDSQRTLSLFTPSIQQVVYRAWSSPDQNDSSASVMSPISPPLSRTQSQTGGIFASIDNASTSSAQSRTPTGPTQSFSSYGLSLGASRHSRAHARRRKKRVVDLRSRPTTPSDSASVSVSDESTYTESASAPSVTSAPLQAIHEQPDDPVTPPLSPESDQSLPAIVEERRLSLSRSLPRRDLSSEIVRDRAEPSEPRNPFNTDDVIVTVGSVRPTPHQEASPPLGPTRQLSAAGLPFPHDSSTGSVVDQVFLDTLAGEVARRMRDEKLMAPNSCGTFCGHGLPEEPPPPAYGQ
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34-1.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: TTY1A_XENLA
Sequence: MSTSHGYRASWWTNILHQVPHTNFQFEVVDNQFAPQEWPYQQALLFLASIAGLCLAISLILICVYLIRFCCCASQEDDDSKNHRVCCVTWSCVAAVIICCAGIGIGFYGNSETNDGVYQVTYSLMNTNHTLTSINLLVSDTVELLSSVVKSDLTQLEEIFSKRTEFLVMIRNTRRQVESVAQQLAEISFWKGTELNPNVLAEQVNFIEDYRWLAYILLLLLDLIICLFTLLGLAKRIKWLVIVMTVVSFFVLLLSWGSMGLEMATAVGLSDFCSNPDGYVMNQTQMITNINPDILQYYISCNQDVANPFRQRLTTSQRALSNIHSQLHGLEREAVPQFPTAEKNLLAVQGMLNTTEGNFHHLVALLNCRGLHKDYVDALKGLCYDGMEGILFLLLFSFLSALSFTAAVCSLPRAWKRFQNRDLDYDDMDEDDPFNPQESKRFVQWQSSI
What is the function of this protein?
Probable chloride channel.
What are the official names of this protein?
Protein tweety homolog 1-A.
What is the protein family that this protein belongs to?
Belongs to the tweety family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.