PharMolix/UniProtQA huggingface dataset:
Protein: MTNA_SYMTH
Sequence: MPKQIEPVALDDAGSALVIVDQTLIPNETRYLRLTTPEETWEAIRSLRVRGAPAIGIAAAMGLYLGVKGSEAADFEDFYHEFRQVKAYLASARPTAVNLFWALDRMEACLLRHRDRPIPEIKEALRAEAEAIREEDARANRTIGEYALSLLKPGMGILTHCNAGALATAAYGTALAPIYLGQERGYNFRVFADETRPLLQGARLTAYELMQAGVDVTLICDNMASAVMKNGWVDAVFVGCDRVAANGDTANKIGTSGVAILARHYGIPFYVCAPTSTIDLRCPTGADIVIEERRPEEVTEQWYAKRMAPEGVKVYNPAFDVTDADLITAIITEYGIARPPYTESLKELFRRKEEAERRA
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: MOAC_CLOBA
Sequence: MENKFNHFDNEGNAIMVDVGNKNATERIAIASGKIRVNRDTFLAIEQGTAKKGDVLGVARVAGIMAAKKTSELIPLCHPLMITNCTIDFELLPKTLEVEVTSKVKVTGNTGVEMEALTAVSTTLLTIYDMCKAIDKAMEIDNIHLRRKTGGKSGDFINE
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: GLGC_ECOSM
Sequence: MVSLEKNDHLMLARQLPLKSVALILAGGRGTRLKDLTNKRAKPAVHFGGKFRIIDFALSNCINSGIRRMGVITQYQSHTLVQHIQRGWSFFNEEMNEFVDLLPAQQRMKGENWYRGTADAVTQNLDIIRRYKAEYVVILAGDHIYKQDYSRMLIDHVEKGARCTVACMPVPIEEASAFGVMAVDENDKIIEFVEKPANPPSMPNDPSKSLASMGIYVFDADYLYELLEEDDRDENSSHDFGKDLIPKITEAGLAYAHPFPLSCVQSDPDAEPYWRDVGTLEAYWKANLDLASVVPELDMYDRNWPIRTYNESLPPAKFVQDRSGSHGMTLNSLVSGGCVISGSVVVQSVLFSRVRVNSFCNIDSAVLLPEVWVGRSCRLRRCVIDRACVIPEGMVIGENAEEDARRFYRSEEGIVLVTREMLRKLGHKQER
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: MERR_BACCE
Sequence: MKFRIGELADKCGVNKETIRYYERLGLIPEPERTEKGYRMYSQQTVDRLHFIKRMQELGFTLNEIDKLLGVVDRDEAKCRDMYDFTILKIEDIQRKIEDLKRIERMLMDLKERCPENKDIYECPIIETLMKK
What is the function of this protein?
Mediates the mercuric-dependent induction of mercury resistance operon.  In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.
What are the official names of this protein?
Mercuric resistance operon regulatory protein.
Protein: FRL4A_ARATH
Sequence: MGSVPDPGELTELAQPSFEEFQKQTSLMTSCTLLWQELSDHFTSLEQNLMKKSEALKQMIETLDNQTQTSLESLKRREVTIDHSVEIVAGKVGERARAALESLEKARDGCGDGSNDDSGDVDDEEGLLSALKSLCLKMDARGFWNFVTARKKELENLRSKIPAALVDCVDPAMLVLEAISEVFPVDTRGDKVSNDYGWACVVILESLTPVIVDPVIGKSRLLVTPSVKEKAKEIAETWKKSLEERGRIENVKTPDVHTFLQHLVTFGIVKSEDLALYRKLVVGSAWRKQMPKLAVSVGLGDQMPDMIEELISRGQQLDAVHFTYEVGLVDKFPPVPLLKAYLRDAKKSAASIMEDSSNTGRATHLVARKEQSALKAVLKCIEEYKLEEEFPPENLKKRLDQLEKTKTEKRKPAAVPANKRTRASYNGPMPPAKAGRITNAYVSSFPFIRSPSHSPQYASPAAYPSPPTTVYSNRSPPYPYSPEIIPGSYQGSPIGYPAYNGYCNGPVPAPAPPVYHPHHHQHHQFHHQQHYY
What are the official names of this protein?
FRIGIDA-like protein 4a.
What is the protein family that this protein belongs to?
Belongs to the Frigida family.
Protein: PG067_VARV
Sequence: MLILTKVNIYMLIIVLWLYGYNFIMSGSQCPMINDDRFTLKRKYQIDSVESTMKMDKKRTKFQNRAKMVKEINQTIRAAQTHYETLKLGYIKFKKMIRTTTLEDITTSIPNIQKIYKLFSDISAIGKVSQNPSKMAYALLLYMFPNLFGDDHRFILYRMFPMSKIKHKIFSPFKLNLIRILVEERFYNNECRSNKWRIIGTQVDKMLIAESDKYTIDARYRLRPIYRIKGKSEEDTLFIKQMVDQCVTSQELVEKVLKILFRDLFKSGEYKAYRYDDDVENGFIGLDKLKLNIVHDIVEPCMPVRRPVAKILCKEMVNKYFENPLHIIGKNLQECIDFVSE
What is the function of this protein?
Major early protein present in virus factories.  The presence of BEN domains suggests a possible role in organization of viral DNA during replication or transcription.
What are the official names of this protein?
Protein OPG067, Protein E5.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG067 family.
Protein: ACR2_NEUCR
Sequence: MALKKMPPKKPYHQKASKTKACYNCHRKRLRCDKSLPACLKCSINGEECLGYGIVLRWAACNSPTSTITTRTTNKTNFNGTNTTTPRTVKSSTPTQAPTPSDSPRQLDTDVTSSSAPSHTCSRSTTTSTTTTRISSPTLEETIDSFTVETPIDNNVDPLPRAPDDNPDPSSQIIKRPVNLIKIPLTDPLLNGLSTKARWYMHHFATIVCRDLVSIDQKERNPFRAIIPLVRKFDYLQSVVLATAAMHLSTIHKYQGRSLPSESALVDALMLKSRALHLLRAAINDNTLTDKAMILSAIVFLVNLDLIDSGRGGWKAHVGAARRLISSLYLTKAHLDGAIAPLVNAIAADCLTYRIYGSTISGNTSSWSDNTIDDGVVLPYILQNAEAYSYHCAPPAILQIILSASQLCSGSSTTLETDGGAGRIVTAAALLHKARNFDVQTWVYNIKGLPPDDDLEARVSVASAHRAAACLFVLLSVPETGLLEIPLLEPKDLVQEILGHLSCIPDNHVHLKGTVWPTFVVGAETDDLSERAWCLERLVAVWTKNPWTYPWGYVHTAMEMLQEIWRLKDLAAQQGDDGINWLQRLKATENSCLIV
What is the function of this protein?
Probable transcriptional regulator.
What are the official names of this protein?
Acriflavine sensitivity control protein acr-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS6_ENT38
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTGAITAAEGTIHRLEDWGRRQLAYPINKLHKAHYVLLNVEAPQEAIDELETNFRFNDAVIRSMVMRTKNAVTEASPMVKAKDERRERRDDFANETADDSDAGDSEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RS15_LIMRT
Sequence: MAISKERKDQIIKEFATHEGDTGSTQVQVAVLTADINELNDHLRTHKHDYHSQRGLMKKIGHRRNLLAYLRRTDLPAYRELIQKLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: EDN1_RABIT
Sequence: MDYFSMMVSLLLVAFHGAPETAASGTELSTGAENPGEKPPASAPWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPGHIVPYGLGSPSRSKRSLKDLFPTRAAYHKNRCQCTSPHDKKCWNFCQAGTELRAQETMEKGRNNLKKGKDCSKLGKKCILQKLMQGRKIRRLEAISNSIKTSFHAAQLRAQLHREQKVTHNRTH
What is the function of this protein?
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity).  Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
What are the official names of this protein?
Endothelin-1, ET-1, Preproendothelin-1, PPET1.
What is the protein family that this protein belongs to?
Belongs to the endothelin/sarafotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR9_STRPI
Sequence: MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGVDTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAAKDNKIELIDLVVVNLYPFKETILKPDVTYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELAANGETSYETRQRLAAKVFRHTAAYDALIAEYFTAQVGESKPEKLTLTYDLKQPMRYGENPQQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHMNPCGIGQADDIETAWDYAYESDPVSIFGGIVVLNREVDAATAEKMHGVFLEIIIAPSYTDEALAILINKKKNLRILALPFNAQEASEVEAEYTGVVGGLLVQNQDVVKESPADWQVVTKRQPTETEATALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRLAIDQAKDRLDGAILASDAFFPFADNVEEIAKAGIKAIIQPGGSVRDQESIEAADKYGLTMVFTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: UPP2_HUMAN
Sequence: MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVKFVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPSISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDNIVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLDYLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQRPQLLISNFIRRRLGLCD
What is the function of this protein?
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:12849978, PubMed:21855639).  The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable).  Shows broad substrate specificity and accepts uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates (PubMed:12849978).
What are the official names of this protein?
Uridine phosphorylase 2, UPase 2, UrdPase 2.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: SYS_ACIAD
Sequence: MIDPKLLRNNIEAVNLALAKRGVQLDPTEWASLEVRRKELQSKTESLQAERNAGAKQVGQIKKAGGDASEIMTRMQAIGDEIKAAEVALAELQAEIEQKALSIPNLPDESVPEGKDENDNVEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGSRFSVLKGPLARLQRALTQFMLDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFVRDEIIDAERLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPEDSMQALEELTGHAEGILQALGLPYRKILLCGGDMGFGSTKTYDLEVWVPSQNTYREISSCSNMGDFQARRMMARYRTDQKKTELVHTLNGSGLAVGRTLLAVMENYQRADGAIEVPEVLRPYMGGATYID
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITPA1_TRYCC
Sequence: MAEGSALLRGSSNHKVTLVTGNDGKRREVQACLEGHVLVENVNLDLPEMQSDSVFEISRNKALMAYDITKSPVLVEDTALCFDALGGLPGPYVKWFFERIGPTGLIKLLEGFDTRRAYATCVFTYCASPDVVLQFEGRCDGRIVEAPRGEGGFGWDSVFEPDEGCGQTFAEMQDEEKNRISPRAKALVALKAHFCL
What is the function of this protein?
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase 1, ITPase 1, Inosine triphosphatase 1, Non-canonical purine NTP pyrophosphatase 1, Non-standard purine NTP pyrophosphatase 1, Nucleoside-triphosphate diphosphatase 1, Nucleoside-triphosphate pyrophosphatase 1, NTPase 1.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHH_GOSHI
Sequence: MNLSATEKDLMIVNMGPHHPSMHGVLRLIVTLDGEDVVDCEPILGYLHRGMEKIAENRTIIQYLPYVTRWDYLATMFTEAITVNGPEQLGNIQVPKRASYIRVIMLELSRIASHLLWLGPFMADIGAQTPFFYIFRERELVYDLFEAATGMRMMHNYFRIGGVAADLPYGWLDKCLDFCDYFLTGIVEYQKLITRNPIFLERVEGIGVIGGEEAINWGLSGPMLRASGIKWDLRKVDHYECYDEFDWEIQWQKEGDSLARYLVRISEMTESIKIIQQALEGIPGGPYENLEIRCFDRERDPEWNDFEYRFISKKPSPTFELPRQELYARMEAPKGELGIFLIGDQSGFPWRWKIRPPGFINLQILPQLVKRMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RBFA_CAMJR
Sequence: MNPSEIKKLRTESILKELIPEALANLDDENLKNLCVVDVECKKGRYDAFVYLDKMFFNVHEQEKILSSLKKASRALQNYCMSEQGWYRCPNFHFKFDDRLEYQNHMDALFEKIKKDKNES
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_LARHH
Sequence: MQNQKIRIRLKAFDYHLIDRSAQEIVDTAKRTGAVVKGPVPLPTKIERFDILRSPHVNKTSRDQFEIRTHLRLMDIIDPTDKTVDALMKLDLPAGVDVEIKLQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: OLF9_APILI
Sequence: CSSTEANELVMSVIVGTVVIVSSLIILISYALILFNILHMSSAEGWFKAIGTCGSHIIIVGLFYEFGLITHVKLSSDWYMGQGKL
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor-like protein HbT9.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CALM_KARVE
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLSLMARKMKDTDTEEELIEAFKVFDRDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKMMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: GSTA_BPT4
Sequence: MRICIFMARGLEGCGVTKFSLEQRDWFIKNGHEVTLVYAKDKSFTRTSSHDHKSFSIPVILAKEYDKALKLVNDCDILIINSVPATSVQEATINNYKKLLDNIKPSIRVVVYQHDHSVLSLRRNLGLEETVRRADVIFSHSDNGDFNKVLMKEWYPETVSLFDDIEEAPTVYNFQPPMDIVKVRSTYWKDVSEINMNINRWIGRTTTWKGFYQMFDFHEKFLKPAGKSTVMEGLERSPAFIAIKEKGIPYEYYGNREIDKMNLAPNQPAQILDCYINSEMLERMSKSGFGYQLSKLNQKYLQRSLEYTHLELGACGTIPVFWKSTGENLKFRVDNTPLTSHDSGIIWFDENDMESTFERIKELSSDRALYDREREKAYEFLYQHQDSSFCFKEQFDIITK
What is the function of this protein?
Catalyzes the transfer of glucose from uridine diphosphoglucose to 5-hydroxymethyl cytosine of T4 DNA to yield glucosyl 5-hydroxymethyl cytosine (glc-HMC) (PubMed:15381072).  This DNA process seems to occur immediately after DNA synthesis since the DNA alpha-glucosyltransferase interacts with the clamp protein gp45 (PubMed:15381072).  The glc-HMC modification protects the phage genome against its own nucleases and the host restriction endonuclease system (PubMed:15381072).  The glc-HMC modification also protects against the host CRISPR-Cas9 defense system (PubMed:26081634).
What are the official names of this protein?
DNA alpha-glucosyltransferase, AGT, Alpha-GT.
Protein: MTREX_HUMAN
Sequence: MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLYL
What is the function of this protein?
Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447).  Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:27871484, PubMed:29844170, PubMed:21855801).  NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation.  NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170).  PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation.  The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei.  Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484).  Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5. 8S rRNA (PubMed:17412707, PubMed:29107693).  May be involved in pre-mRNA splicing.  In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170).  Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors.  Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447).  Plays a role in DNA damage response (PubMed:29902117).
What are the official names of this protein?
Exosome RNA helicase MTR4, ATP-dependent RNA helicase DOB1, ATP-dependent RNA helicase SKIV2L2, Superkiller viralicidic activity 2-like 2, TRAMP-like complex helicase.
What is the protein family that this protein belongs to?
Belongs to the helicase family. SKI2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus. Nucleus speckle.
Protein: ATPD_NOSS1
Sequence: MTSKVANTEVAQPYAQALLSIAKSKSLTEEFGTDARTLLNLLTENQQLRNFIDNPFIAAENKKALIKQILSEASPYLRNFLLLLVDKRRIFFLPEILQQYLALLRQLNQTVLAEVTSAVALTEDQQQAVTEKVLALTKARQVELATKVDSDLIGGVIIKVGSQVIDSSIRGQLRRLSLRLSNS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: MTNA_KORVE
Sequence: MTKSVIKTVEWSDEGVVLVDQTKLPTEEVYVTCGTYEEVAVAIKDMIVRGAPAIGVTAAMGIALGVRDAKASTLSELRQMFGMICRTMGETRPTAVNLFWAIRRMQRKFEELSNMPLAVIKAEMVFEAKRIHLEDIAANQAMGRNGAVLMPSEGGVLTHCNAGALATAGYGTALGVIRAAVESGKNIRVFADETRPFLQGARLTAWELMKDGIDTTVISDNMAGAMMAQGKIQAVVVGADRIAANGDVANKIGTYTVAVLAKEHGIPFYVAAPWSTIDLDTPDGSKIPIEQRNGREVTHIAGKQMTPDNVRIENPAFDVTPSKYVTAIITERGVAKAPYDESLRKLAETETVSA
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: LONP2_ASPFU
Sequence: MGSNNGRAMKLALVPLPKGSVLLPGVTLRIPVSNRPDLANLLSALLDQTNLGKRDGNTITFGCVPLRSPLLSNDGQQLIDDGSVDGAKKEEFDAIDAGQARKEDLFRYGTVGKVIGVQRRAYAEPFLVVQGVQRFTIKHILRERPFFEGEVVLHNERDAISSDAETVELFQQLRQLSRELITLLRLSSLLPSTGTRLSPLVARKFEVYIAKTDLSQAGNLADFMADVADPTFEEKLRVLASFALRTRLERVVELLARQVQGIKNSVKVTTISTSSFPSNSPFDISQIDPRDRELLARRVMAGLTGLTPPGAAGGRNNEDEKETNEVDELQKRLQEAELSPEARKVADKELRRLRKMNPANAEYGVCRTYLENIADIPWTKVTEDKLGPETLKRARNQLDEDHYGLETIKKRLLEYLAVLRLKQSTNQDVERQIAALTKELDAANEVLAEKDVPALSESDRVSLEAKLNLLQSRRLADKSPILLLVGPPGTGKTSLARSVATSLGRKFHRISLGGVRDEAEIRGHRRTYVAAMPGLIVNGLKKVGVANPVFLLDEIDKVGGANFQGDPSAAMLEVLDPEQNSTFVDHYINIPIDLSKVLFIATANSLDTIPAPLLDRMETITLSGYTTVEKRHIAKRHLIPKQIRANGLAEGQVVLSDEVVDKVITSYTRESGVRNLERELGSICRHKAVQYADAVDNGRLDTYNPVVALGDLEDILGIERFDEEIAEKHGRPGVVTGLVAYSTGGQGSILFIEVADMPGNGRVQLTGKLGDVLKESVEVALTWVKAHSFELGLTHDPNEDIMKNRSLHVHCPAGAIPKDGPSAGLAHTIGLISLFTGKAVPPQIAMTGEVSLRGRVMPVGGIKEKLIGAHRAGVKTVLLPEQNRKDVKDVPQEVHDGLQIVYVRHIWEAIRQVWPGAHWPGQHHINFVESRL
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix.  Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
What are the official names of this protein?
Lon protease homolog 2, peroxisomal.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Peroxisome matrix.
Protein: PERT_PIG
Sequence: MGARAVLGVTLAVACAGAFFASILRRKDLLGGDTEASGVAGLVEASRLLVDEAIHTTMRRNLRKRGIFSPSQLLSFSKLPEPTSRTASRAAEIMETAVQEVKRRVCRRRDTDQLPTDVLSEELLSTIANLSGCLPHMLPPSCPHTCLANKYRLITGACNNRDHPRWGASNTALARWLPPAYEDGVTEPRGWNPHFLYNGLPLPPVREVTRQVIHVSNEAVTEDGQYSDLLMAWGQYIDHDIAFTPQSTSKAAFAGGADCQLTCENRSPCFPIQLPTNASGAAGATCLPFYRSSAACGSGRQGALVGNLSWAAPRQQMNGLTSFLDASTVYGSSPAQEQRLRNWTSAEGLLRVNTRHRDAGRAFLPFAPPPAPPACAPEPGTPAARAPCFLAGDSRASEVPGLTALHTLWLREHNRLAAAFKALNAHWSADTVYQEARKVVGALHQIVTLRDYVPKILGAEAFGQHVGPYQGYDPAVDPTVSNVFSTAAFRFGHATIHPLVRRLDARFQEHPGSHLPLRAAFFQPWRLLREGGVDPVLRGLLARPAKLQVQDQLMNEELTERLFVLSNSGTLDLASINLQRGRDHGLPGYNEWREFCGLSRLETWADLSAATANGRVADRILGLYQHPDNIDVWLGGLAESFLPGARTGPLFACIIGKQMRALRDGDRFWWENPGVFTEAQRRELSRHSMSRVICDNSGLSHVPLDAFRVGQWPQEFEPCASIQGMDLGAWREAPPSGDACGFPDPVEDGGFLLCEERGQRVLVFSCRHGFRLRGPAQITCTPRGWDSPPPLCKDINECEDETDPPCHASARCKNTKGGVLCECSDPLVLGEDGRTCVDAGRLPRASVVSIALGAVLVCGLAGLAWTVVCRWTHADARPLLPVGEGEGDGKSPSLPLPGCGNRRDVGAAPALEVEQDLSCGSRGLCE
What is the function of this protein?
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
What are the official names of this protein?
Thyroid peroxidase, TPO.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. XPO subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ALLC_YEAST
Sequence: MKFFSLADEAEFKSIIISKNKAVDVIGSKLGGQVVSFSDEWFASAENLIQPTAPIRDPTRFVHSGAWYDGWETRRHNEMEYDWVIIKMGVAAAHIIGGEIDTAFFNGNHAPFVSIEALYDEGEEGNIVEDDSRWVEIVEKFECGPSQRHLFVRGNGLTKERFTHIKLKMYPDGGIARFRLYGRVVPPELKTKDHIIDLAYVCNGAVALKYSDQHFGSVDNLLLPGRGHDMSDGWETKRSRQPGHTDWAVIQLGRESSFIEKIIVDTAHFRGNFPQFITVEGCLKESESSENTGEGTWVELVGKSKTGPDKEHVYEIRKSIRVSHVKLTIIPDGGVKRIRVWGY
What is the function of this protein?
Utilization of purines as secondary nitrogen sources, when primary sources are limiting.
What are the official names of this protein?
Allantoicase, Allantoate amidinohydrolase.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.