PharMolix/UniProtQA huggingface dataset:
Protein: NUOK_MYCGI
Sequence: MNPDNYLYLSALLFTIGAAGVLLRRNAIVMFMCVELMLNAGNLAFVTFARVHGNLDGQVVAFFTMVVAACEVVIGLAIIMTIFRTRRSANVDAASLLRH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRF_TRIV2
Sequence: MTNNKIIVALDVPDTESAIALIDKLESVTFWKVGLELFTSSGPRILEVLKSRQKRIFLDLKFHDIPNTVAGACRGAARYGVDLMTIHATSGRDALKAAKEAVEEGAAQAGVKPSKLIAVTVLTSISARQLALDLKIPVELPEYALDMALMAQEVGLDGAVCSPQEVAQLRQICGDDFVLVCPGVRPTWAEAKDQKRSLTPSQAIQAGADYLVIGRPITAAAEPELAWKRIAQELTTVA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: G3PC_PINSY
Sequence: MGSTGKIKIGINGFGRIGRLVARVALTRDDIELVGVNDPFISTDYMSYMFKYDSVHGKWKHHEVNVKDSKTLLFGEKSVAVFGCRNPEEIPWGEVGAEYVVESTGVFTDKEKASAHLKAGAKKVVISAPSKDAPMFVVGVNEHQYKSDVNIVSNASCTTNCLAPLAKVINDKFGIVEGLMTTVHSITATQKTVDGPSNKDWRGGRGAGFNIIPSSTGAAKAVGKVLPALNGKLTGMAFRVPTPDVSVVDLTVRLEKSATYDEIKAAIKAESEGNLKGILGYTEDAVVSTDFIGDSRSSIFDAQAGIALSDNFVKLVSWYDNEWGYSSRVVDLIVHMAATQ
What is the function of this protein?
Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.  Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YISQ_BACSU
Sequence: MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTLMLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSIGANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAILKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAMIVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGAQALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIAAATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDAKFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWIQKGMA
What are the official names of this protein?
Uncharacterized transporter YisQ.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOC2_JASNU
Sequence: MEVLMAERANLVFHNKVIDGTAMKRLINRLIEHFGMAYTSHILDQVKALGFHQATTTSISLGIDDLLTIPSKRWLVQDAEQQSLVLEKHHHYGNVHAVEKLRQSVEIWYATSEYLRQEMNPNFRMTDPFNPVHIMSFSGARGNASQVHQLIGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGTIRGISLSPRNGMMPERVFIQTLMGRVLADDIYIGTRCLATRNQDIGIGLVNRFITFRAQPISIRTPFTCRSASWICRFCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPSNGKIKFNEDLVHPTRTRHGHPAFLCSIDLYVTIESEDILHNVNIPPKSFLLVQNDQYVESEQVIAEICVGTSTLNFKEKVRKHIFSDSDGEMHWSTDVYHAPEFTYGNVHLLPKTSHLWILLGGPCRSSRVSLSFHKDQDQMNAHSPSIKRRYTSNLSETNDPERQKLFSSYFYGKKKKKNRISDYSNLNQILCTGHCNFISPTTLHQNSDLFSKRRKNKFLIPLQSIQEPENKLMPRSSISIEIPQNGTFRGNSILAYFDDPRYRRKGSGIPQYGTIEMHSIVKKEDLVEYRGVKAFRPKYQMKVDRLFFIPEEVHILPRSSSIMVRNNSLIGVDTQLTLNIRSRVGGFVRVERKKKRIELKIFSGDIHFPGETNKISRHSDVLIPPGKPNSKESKKWKNGIYVQRITPRKKKFFVLVRPVITYEITDGININLATLFPPDLLQERDNVQLRVVNYILYENGNPIRGFSHTDSQLVRTCLVLNWDQDKKKSASSEEARASFVEIRTNGLIRHFLRIDLVKSPISYIGKRNDPSGSGLPSDNGSGWTNMNPFSSIYSKARIQQSLNQNQGTIHTLLNRNTGFQSLRILSSSNCSRMGPFNDVIKYHKESIPITLITKDPFIPIKNFKNSLGPFGTAFPIANFDSFSHLITQNRILVNNYLELDNFKQTFQVIQYYLMDENPKIYNPDLGSNILLNPFNWNWYFYHHTYCQETSPIISLGQFICENVCIAKNAPHLKSGQVILVQVASVVIRSAKPYLATPGTTVHGHYGEILYEGDTLITFLYEKSRSSDITQGLPKVEEVFEVRSIDSISMNLEKRFKGWNKRITRILGMPWGFLIGAELTIVQSRISLVNKIQRVYRSQGVQIHNRHIEIIVRQITSKVLVSEDGMSNVFSPGELIGLLRAERMGRALEEAVYYRAILLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGMIPLGTGFKGLVPPSKQDNNSSLETKKKNLFEGEMRDIFFHHRKLFDSCRSKNFHDTSEQSLLGFHDS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NADE_STAA8
Sequence: MSKLQDVIVQEMKVKKRIDSAEEIMELKQFIKNYVQSHSFIKSLVLGISGGQDSTLVGKLVQMSVNELREEGIDCTFIAVKLPYGVQKDADEVEQALRFIEPDEIVTVNIKPAVDQSVQSLKEAGIVLTDFQKGNEKARERMKVQFSIASNRQGIVVGTDHSAENITGFYTKYGDGAADIAPIFGLNKRQGRQLLAYLGAPKELYEKTPTADLEDDKPQLPDEDALGVTYEAIDNYLEGKPVTPEEQKVIENHYIRNAHKRELAYTRYTWPKS
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: IF1_ALKEH
Sequence: MAKEESIKMNGTVIETLPNTMFRVELENGHVVTAHISGKMRKHYIRILTGDKVTVELTPYDLSKGRITYRAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAP4B_RAT
Sequence: MKMVAPWTRFYSHSCCLCCHVRTGTILLGIWYLIINAVVLLILLSALADPDQYHFSGSELGGEFEFMDDANMCIAIAISLLMILICAMATYGAYKQHAAWIIPFFCYQIFDFALNTLVAITVLVYPNSIQEYIRQLPPSFPYRDDIMSVNPTCLVLVILLFIGIILTFKGYLISCVWSCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATAVTGTAKEPPPPYVSA
What is the function of this protein?
Required for optimal lysosomal function.  Blocks EGF-stimulated EGFR intraluminal sorting and degradation.  Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation.  Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation.  Plays a role as negative regulator of TGFB1 production in regulatory T cells.  Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.
What are the official names of this protein?
Lysosomal-associated transmembrane protein 4B.
What is the protein family that this protein belongs to?
Belongs to the LAPTM4/LAPTM5 transporter family.
What are the subcellular locations of this protein?
Endomembrane system; Multi-pass membrane protein. Late endosome membrane. Cell membrane. Cell projection. Lysosome membrane. Endosome membrane. Endosome, multivesicular body membrane. Endosome, multivesicular body lumen.
Protein: LYPGN_LEGPH
Sequence: MTYSFSKPVSWVFLFTAVIYLVSLSFIQYPATTVLKPIPIVCLIVGVFRTSLSSSAKILLILALVFSLAGDVVLTLPFSLQLELGIACFLLAHCFYITLFLKSFEFNRLHLFYYLPIFLFMGFAAFTMIPYLGNLLIPVMIYFCVLMLMVFSAFQVKKETLTISSGALFFLISDLTLALNLFIYTQADVRIFVMFTYYVAQFLLTFGLVRLYEKGG
What is the function of this protein?
Specifically hydrolyzes the vinyl ether bond of lysoplasmenylcholine (pLPC) and lysoplasmenylethanolamine (pLPE) to release a fatty aldehyde and glycerophospho-choline or glycerophospho-ethanolamine (PubMed:25445671).  Has no activity on diradyl plasmalogen, 1-alkenyl-glycerol, and monoacylglycerophospho-ethanolamine or monoacylglycerophospho-choline (PubMed:25445671).  May serve to protect the bacterium from lysis by lysoplasmalogen derived from plasmalogens of the host (PubMed:25445671).
What are the official names of this protein?
Lysoplasmalogenase, LpYhhN.
What is the protein family that this protein belongs to?
Belongs to the TMEM86 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MED1_XENTR
Sequence: MSSLLERLHSKYSQNRPWPETIKLVRQIMEKRTGMMSGSHQHLVSCLETLQKALKVSSLSAMTDRLESIARQNGLTSHLSPNGTECYITTDMFYLEVLLDTEGQLCDVKVAHHRENPVSCPELVEQLREKNFEDFSQHLKGLVNLYKVPGDNKLETKMYLALQSLELDLTKMAAMYWQATNASVLEKILHGTVGYLTPRSGGQVMSLKYYVSPYDLFDDTTGASISLSEGHAVPRSLGMNVSVTIEATSAMYKLPIAPLIMGSHPIDNKGTPSFTSITNANSVDLPACFFLKFPQPIPVSRAFIQKIQHCTGIPLIDGSHTFLPHYELVTQFELAKEKEPGTLNHNMRFYASLPGQQHCYFVNKDAPLPDGRSLQGTLLSKIPFQHPGRVPIILSLIRHQVACNTLIGSCVKRTMLKEDCPGLLQFEVAPLSDSCFSISFQHPVNDSLVCVVMDVQDSSHVSCKLYKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMASGSTALSGITTPTSSYTSGQISSLFNMGIKERHDSAGHGDDFSKVTQNPILTSLLQITSNSGGTLGSSPTPPQHTPPPASSPASNTKNHPMLMNLLKDNPAQDFSTLYGGSPLERQNSSGSPRTELGSSASGKPKKKRPRTGTEKMKNQTEDDFQRELFSMDVDSQNTIFDVGMAGDALDTPHITPAPSQCGTPPNVYQQAIPHTQANMQRMVRIPSTDAIIPDVTDILSDIAEEASKLPGPGEDCPNLGTPVRDSSSSGHSQSTLFDTDVFQVDGGGGSGGENPYPDPVDLIVDSHGSPNSDSPNTFFNSVDFNPDLLNSQSQSGFTDDLNDDSSQSGDNDFKDFAGPGLASLGIVSGLPVDGGDGKYKMALGADTVDFSIIAGGGSKNLGGPDIQETQSRSQSPLLGSDLGKDRPQKQKVKESGNGGGAGGGLSGMQSAGMEGKSMKRSRTPSSDGKSKDKPPKRKKTESDGKSPSHITNRPFTPPTSTGGSKSPGTSGRSQTPPGMATPPIPKITIQIPKGTMSVGKPSSHSQYSSSGSSSSSSSKSHHGHSSLSSSASGKIKSNKSDGSSGMKIGSSGGGMYSGQSGQSNSQSKNSSQSMGKAGSSPITKHGLSSNVNNSSGSKTKPQGKPSVLMNPSLSKPNISPSHSRPSGGSDKLSSPMKPMPGTPPSSKAKSPIGSGGQHLSGSGSNSTTKSSSGLVSSGSLTQKPNSSSSSSSSSSSSSSSSSSSSSSFSSGVSQNLHSSSKGKSPSRNKKPSLTAVIDKLKHGVGTGGPGSEDPMDGGVGGGSTGAPSHGMSSKHGLGVGEFPTKREKGEKDKSKGSSGGPSDPSKKGGGDSKGSVSTGVAKIIISKHDGGSPSIKAKVTLQKPEGGGEGLRSQMQKNYGSPLISGSTPKHERCSPSHNKSPAYTPQALDSESESGSSSIAEKSYQNSPSSDDGGGSGSRAQTEYSAEKHKKHKKEKKRLKDKDRDREKKKSYTMKPESWSKSPISADPTMAMGGGAMMSSDRASRPTPSFLMGDDDDLIDVPLTL
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 1, Mediator complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHEB_NITEU
Sequence: MKKISVLIIDDSALIRKLLTEIINARPDMEVIGAAPDPIVAREMIRTLNPDVLTLDVEMPKMDGLEFLEKLMRLRPMPVVMVSTLTERGSEVTFRALELGAVDFVAKPKMDIRNSLEAYTDEITGKIRTASTARIHRLEPVASNGAASGSIVQMPRHHGISTEKLIIIGASTGGTEAIKDVLIHLPPDCPGILITQHMPEGFTRSFAERLDRLCKIRVKEAEGGERVLPGHAYLAPGHSHLLLKKSGANYVTELSQTDPVNRHRPSVDVLFQSAAHCAGKNAVGVILTGMGKDGAAGMLDMHHAGAYNLAQDETSCVVFGMPKEAITLGAVDEIVPLQDMARRILARLVGAGKQAVRV
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_NATTJ
Sequence: MTHPQKTPLYDIHKERGGKIIDFGGWYLPVQFTGIIDEVMTTRKEAGLFDVSHMGEIIVEGPKALEYLQKMVPNDVARLKPGKILYTPMCYENGGTVDDFLIYKMDENKFLLIVNAANTDKDFEWLQENNTEGVELKNLSDEYGQIAIQGPKAEKILQRLTDTPLKEIKFFNFKEDVDLDGVKALISRTGYTGENGFEIYIKAEETAKLWEKIEDAGENDGLKPIGLGARDVLRFEVCLPLYGNELSPEITPLEARLNPFVKLNKTEDFLGKDVLVNQKEQGLERVLVGFEMIDRGIPRTNYILMKDGQEIGFVSSGSQSPTLDKALGLGFIKPEHDQEGNEIEVKIRKKTAKAKIVKTPFYRRG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: DOT1_CRYNB
Sequence: MFSFFGDESKLPASTVMVSRMTVKKQAAARQQSSGPMAGPSKPSNVTPKHSHGSLKGTPRSASEKGTPKQGPSSSSKSTSKVKQEERIRPSTIPRTPASSSSPGRLKRKTPKVQVVESESSSGSESSDDALDSKPKRPKVTRKETGIDMTPLPGEQVVGRRVFCWDKVDMRGEWGRGWAGFVGCDEVVRGNVQGWANGGGGDGSKNLGKYRAFFPQEGFDRDGDFLPSVEVLYPAKGCREKFVLMVPSSDREFNPIGELRNTLRLILEHYIPPSHRHIFGNLAESLDISNPLSSLPSRMTTPLPNSLVTPPPDPASPSPAFAFEISATSTPAPSTERQETIADLIRKSLAPNRRDGPLFVTAIERYNSAMQAIQEDGTLQQWLDEGMNGGKGIKVREWAALVDFVHDQAYSRVVGGYSHELEHHPKHPEEVSKAISGKEDAYGELRHAFMSKIIEQTKLGPDSVFVDLGSGVGNCVLQASLQAGSRSYGFELLPVPAHCARLQVREVQRRWAMWALKGNLDVEVHEGDFRVHKEVGRRLREADVVLVNNEVFPSSLNMDLADMFLDLKEGAKIVSLKPFVPEGFRMNESNCDSFAAILRSTQHDYYRDWVSWKGEWGNYYVAVIDRSRRIKFEESMTGRASRRR
What is the function of this protein?
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3.  This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks.  Nucleosomes are preferred as substrate compared to free histone.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone H3-K79 methyltransferase, H3-K79-HMTase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS13_ONYPE
Sequence: MARIAGIDIPSDKRVVIALTYIYGLGNKLSHKILNELNIDQNIRVKNLTEQQLSALRSEITKYNVEGDLRREVTLNIKRLMEIGAYRGLRHRKGLPVRGQKTRNNAHTVKGKPKAIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RL27_BIFAA
Sequence: MAHKKGASSSRNGRDSNAQYLGVKKFGGEAVVAGNIIVRQRGTKFHPGENVGMGKDHTLFALKDGSVKFGVRRDRKVVDVIAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RL22_LEPBA
Sequence: MEAKAVGKHLRISARKARLVADEVRGYDYKEAIDILRFTNKAASSMIINLLNSAVANAIQMNESLDPNSLFVKKIYVDDGPIMKRFRPRARGRASRIRKRLSHITVVVSEIEKKVS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: TTCA_BRUO2
Sequence: MNAFDADITEHADSSGCHPLFRDVPATVEFNKLRKRLLRLTRQAIEDFAMVKPGDRWMVCLSGGKDSYGLLALLLDLKWRGLLPVELLAVNLDQGQPNFPKHILPDFLTRYGIEHRIEYQDTYSIVTDKLPETSTYCSLCSRLRRGNLYRIAREEGCSAIVLGHHREDILETFFMNLFHGGRLAAMPPKLLNDEGDLMVFRPLAYAAEDDLEKFANAMQFPIIPCDLCGSQDGLQRNAMKAMLIDIEKRMPGRKDTMIRALTNVRPSHLLDRKLFDFAGLMANGEKGSDDALW
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_FRATO
Sequence: MAINNQRIRIRLKAFDHKLIDISTQEIVDTAKKTGAQVKGPIPLPVRKEKFTILISPHVNKKARDQYEIRTHKRLIDIVEPTDKTVDALMKLDLASGVDVQISLS
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RLMH_LACDA
Sequence: MNIKIVCVGKLKEKYFKDGIAEYQKRLSRFAKVEIVQVPDEKAPESLSPAQMEEVKKREGERILSKIKDKEYVYVLAIKGKERASEEFAKELKNLGTYGHSDITFVIGGSLGTSDAVNKRANDLFSFGKLTMPHQLMRLVLIEQIYRAFMINSGSPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_PERMH
Sequence: MIAVIQRVNRSYVEVDGKVVGEIGKGLNILLGVVKGDTEEDIDKLIKKIPFLRIFEDENGKMNLSVIDIKGEALVISQFTLAGSVKKGRRPSFDNAEEPERAKELYQRFVERLSEYIPVKTGVFAAHMKVFIENDGPVTFIIDSKAL
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAPD5_MOUSE
Sequence: MFRSGERPLGGLAVPAEQRDFLPLETTNNNNNHHQPAAWARRASAGPSASPVPSAPSSPRPAAALPASESTDPASGSSNKRKRDNKASTYGLNYSLLQPSGGRAAGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVSRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLQNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEEKEALGKCRSNASEPLSKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPPTVTRVGSQDVSLEVSQAVGKMQSTQTTNTPNNANKSQHGSARLFRSSSKGFQGTAQTSHGALMTSKQHQGKSNTQYYHGKKRRHKRDAPLSELCR
What is the function of this protein?
Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity).  Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism.  Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates.  Doesn't need a cofactor for polyadenylation activity (in vitro).  Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs.  May play a role in sister chromatid cohesion (By similarity).
What are the official names of this protein?
Terminal nucleotidyltransferase 4B, Non-canonical poly(A) RNA polymerase PAPD5, PAP-associated domain-containing protein 5, Terminal guanylyltransferase, Terminal uridylyltransferase 3, TUTase 3, Topoisomerase-related function protein 4-2, TRF4-2.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Predominantly expressed in the cytoplasm.
Protein: VXIS_BPHK6
Sequence: MQHELQPDSLVDLKFIMADTGFGKTFIYDRIKSGDLPKAKVIHGRARWLYRDHCEFKNKLLSRANG
What is the function of this protein?
Excisionase and integrase are necessary for the excision of prophage from the host genome by site-specific recombination at the att site.
What are the official names of this protein?
Probable excisionase hkaC.
What is the protein family that this protein belongs to?
Belongs to the phage alpA excisionase family.
Protein: QUEC_CELJU
Sequence: MSRKKAVILVSGGLDSTTVIAIARSQGYDCYTISFDYGQRHRAELKAAEITAKAHGSLEHKVIRLDLGAIGGSALTDTSIDVPEEETSGIPVTYVPARNTVFLSIALGWAEVLGALDIFIGVNAVDYSGYPDCRPDYIAAYETMANLATKRGIEGERLHIRTPLINLTKAQIIQQGLALGVDYRLTVSCYQANDGGEACGKCDSCRLRKQGFEQAGVADPTRYAF
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: UPP_PYRIL
Sequence: MPVKIIDHVYAQYLLTQLRNRNTKGIDFRKGLVRLGRIVGYELVRYFPTREVEVETPLGKAVGIEILGLDKVIIVQILRAAMPFVEGLLKAFPQARLGVIAARRKEEGGVVDVEVFYSKIPTVEREDIVIVADPMLATGITMTRAIEEVYRVGQPGRLIVVSVIATPVGIERVLSKYPETEIFVVAIDPTLNDKAFIVPGLGDAGDRAFST
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: LAEA_COPC7
Sequence: MSLKYYLNDLSDSDSESESECAEGSSPQDEQNGFYDYRSPPDSADTSIFEDTGRSSSERPMSPTEVCSTDFEEKVPFSSELVVIPESMLKKREEYGRFFSNFKKAIYHLPADEEEWDRQERLHQSFIEMFGRKYPPELSEILKSDEYYEKRCLDLGCGTGCWIKEVARDFPYCEAVGVDLVVVPDTRDFPPNLRCEMDDVNLGLQHFFGRFDVVHARLLSSGIKDYQLLIENIARTLRPGGLVELQEYDFHIYDCNRRRFELSTNELAPPWWPRWMTFFNEAIRKMQGDVDAATHLLKWVRTHPGFEQVRYEERWIPIIPGNLDPLEPMYARLQADVSVYLRSGRPLLLKSGLSEMEVDILENNAIREFYESETTQYTRLQCVCARRNNAVLDHLPPSYNFR
What is the function of this protein?
Methyltransferase that performs automethylation (By similarity).  No other methyl-accepting substrate has been identified yet (By similarity).  Acts as a global regulator for secondary metabolite gene expression (PubMed:31496254).  Negatively regulates the production of coprinoferrin, a structurally novel acylated tripeptide hydroxamate siderophore (PubMed:31496254).
What are the official names of this protein?
Secondary metabolism regulator laeA, Methyltransferase laeA.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.