PharMolix/UniProtQA huggingface dataset:
Protein: CLPX_LEPBA
Sequence: MTKRASQTGNSREKLHCSFCGKAQDEVRRLVAGPGVYICDECISLCNEIIAEEPQSGEKTAIVGDIPKPTEIKKILDQYVIGQEQAKKALAVAVYNHYKRIFHNERKAGDVELEKSNIMLIGPTGSGKTLLAQTLARILKVPFAIVDATALTEAGYVGEDVENIILKLIQNADNDVKRAEMGIIYIDEIDKISRKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYIPVETKNILFICGGAFVGLTDIIKQRVGVKSIGFHSNEVVNDRGRKIEEGESLVHHVIPDDLMKFGLIPEFIGRLPIIATLDELTIESLKSIFTEPKNSLLKQYQKMFDIENVKLKFTESAIEAIAQTAIKRESGARGLRAIVEEIMMELMFQIPSRKDVLEVVVTDDTVLKKEAPITILKGDIEKIA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: LIPB_COXBU
Sequence: MNDVIIRQLAHLIPYQPLWEAMQTFTARRQSQTTDEIWFLEHEPVFTQGLAGKPEHVLNSGNIPLIRTDRGGQVTYHGPGQLMMYLLLDLNRLGLSTRTFVRTIENTVAESLQEWGIPAQGKETAPGVYVDDKKICSIGLRVRKGFSYHGLALNVAMDLTPFSCINPCGFKGLTMTQIQDYVNPIEMDAVKRTIIPLFLKNFGYNQPAIMVETSLEFLIDDHLRSFSEKLGERETVTNSRQN
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_STAAC
Sequence: MAKKGKKYQEAASKVDRTQHYSVEEAIKLAKETSIANFDASVEVAFRLGIDTRKNDQQIRGAVVLPNGTGKSQSVLVFAKGDKIAEAEAAGADYVGEAEYVQKIQQGWFDFDVVVATPDMMGEVGKLGRVLGPKGLMPNPKTGTVTMDVKKAVEEIKAGKVEYRAEKAGIVHASIGKVSFTDEQLIENFNTLQDVLAKAKPSSAKGTYFKSVAVTTTMGPGVKIDTASFK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: GRPE_YERPY
Sequence: MSSKEQKTPNEQVSEEMENTAEQQVEATQETGECVDPRVAELEVQLSDALQRERESLLRAKAEVENIRRRTELDVEKAHKFALERFSSELLPVIDNLERALDTADKTNTELTSMIEGVELTLKSLLDAVGKFGIEVVGETHVPFNPEVHQAMTMLESADHEPNHVMMVMQKGYTLNGRLLRPAMVAVSKAKS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FETP_NEIMA
Sequence: MARMVFCVKLNKEAEGMKFPPLPNELGKRIFENVSQEAWAAWTRHQTMLINENRLSLADPRAREYLAQQMEQYFFGDGADAVQGYVPQ
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: AZOR_CALBD
Sequence: MAKLLYIKANPKSNQSSRTFIISEHFIKVYKEFHPNDQIITLDLYKEGIHFLSQEDINDIFAPKTEASKHHHILKYAYQFAEADKYVFAAPMWNLGIPAILKAYIDYITVSGITFKYTEQGAVGLLRGKKAVHIMATGGEYKTLPFSDFEMANRYLKTILGFMGVEDFKTITAQRLDIVGEDVEKIMFTALKEAEEIAKGF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: CSLA1_CYATE
Sequence: MRNLIFEEPEGIPGNSSSSLRYAWQSIRAPVIIPLLKLAVIVCSVMSIMLFVERVAMAAVILIVKVLRKKRYTKYNLEAMKQKLERSKKYPMVLIQIPMYNEKEVYKLSIGAVCGLSWPADRFIVQVLDDSTNPVLRELVEMECQKWIQKGVNVKYENRRNRNGYKAGALKEGLEKQYVEDCEFVAIFDADFQPDADFLWNTIPYLLENPKLGLVQARWKFVNSEECMMTRLQEMSLDYHFSVEQEVGSSTYSFFGFNGTAGVWRIQAIKDAGGWKDRTTVEDMDLAVRASLHGWEFVFVGDVKVKNELPSTFKAYRFQQHRWSCGPANLFKKMTKEIICCKRVPLLKRLHLIYAFFFVRKIVAHWVTFFFYCIVIPACVIVPEVNLKKQIAIYIPATITILNAVSTPRSMHLLVLWILFENVMSLHRTKAAIIGLLEANRVNEWVVTEKLGNAMKQRNNARPSRASRFRIIERIHPLEIIVGMYMLHCATYDLLFGHDHFFVYLLLQAGAFFTMGFGLVGTIVPT
What is the function of this protein?
Possesses 4-beta-mannosyltransferase activity on mannan using GDP-mannose.  The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase.  The galactomannan is a hemicellulosic storage polysaccharide accumulated in the form of secondary wall thickenings in the seed endosperm.
What are the official names of this protein?
Glucomannan 4-beta-mannosyltransferase 1, CtManS, Glucomannan synthase, Mannan synthase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: EFC12_HUMAN
Sequence: MDDDYEAYHSLFLSLLGLCPSKTPINENAPVFDPEPVIAHCFKQFQQKDFRLPQTRRRIIMVPRKEDQTPLNPASQPQAPPKPIPSFKVLEARDIQEQPEDRKTWLSQRSKLRQELESFGDVKRWLENKPSITPSEAKVLHMIHEEQSAQPNASQATTRTTRKKAPRLSRLSRQMVPQLQLPEPPALSVMYSYLHSRKIKILEIFHKVGQGENQRITREEFIAAVKAVGVPLKNQEVEDIVIYLSSLGKHNTITMDILANTYKQWSMAQQRSSLATAREHYILAKHRDSLKGPLKKQEVDSAPQLPKVDLLTVPAVDTQMETRPMTLEEMEEVGKRYRERQRQHKLTIPSIQYTEQCHLVRCGNRHFDEHCLPSTIHGDMRELIDSARRHNFLVYLQCWKLCKSYGLPLTEDILMKALLYPGDKIIFQMDKVCPIRQPGGYYSDWKVFSPNLALLRSQGPGKSKRTDKKTPKKSKKMRFKEFEEFTRKLKVKRSSGLQQTHPNSFWPGHLLDKLQLYLPTVATDRSLALFSCVQHQPHVYPATYHPDHWWPLRNKNYMTHAHYDAAKVYYIN
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 12.
Protein: YHEU_SALPC
Sequence: MIIPWQGLAPDTLDNLIESFVLREGTDYGEHERSLEQKVADVKRQLQSGEAVLVWSELHETVNIMPKKQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: CYB_DIDAL
Sequence: MTNIRKTHPLMKIINDSFIDLPTPSNISAWWNFGSLLGVCLVIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNIHANGASMFFMCLFLHVGRGIYYGSYLYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGNTLVEWIWGGFSVDKATLTRFFAFHFILPFIILAMVVVHLLFLHETGSNNPTGLDPNSDKIPFHPYYTIKDILGLFLTIITLLSLAMFSPDLLGDPDNFTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLIMPLLHTSTQRSMMFRPISQTLFWMLTANLIILTWIGGQPVEQPYITIGQWASISYFTIIIILMPLAGMLENYMLKPKFP
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: THEM6_DANRE
Sequence: MLLWFLSGSLLLFGTFDVWYFLRGLWVALRCCFQSPIRDVLAEQVVHGRVLLHDMDFMCHMNNARYLRECDFARFAHGTRIGLFMAARALKATMVVGATTIRYRRSLALGEGFELRTRIVSWDEKSFYLEQRFVSKSDGFISAVMLCRQNVIRGSPQNILEFLCKRKVDCPDISEDLQHWIRFISASSQALRAESGLDDKTK
What are the official names of this protein?
Protein THEM6.
What is the protein family that this protein belongs to?
Belongs to the THEM6 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DIPPS_ARCFU
Sequence: MILPCESFNGVPSGCLIIEMNWYSVLKASTAIFFPEKYSSSTSSLSKRSPISAPMINVDGEYLKIFAGRIKLMKAVILAAGLGTRLGGVPKPLVRVGGCEIILRTMKLLSPHVSEFIIVASRYADDIDAFLKDKGFNYKIVRHDRPEKGNGYSLLVAKNHVEDRFILTMGDHVYSQQFIEKAVRGEGVIADREPRFVDIGEATKIRVEDGRVAKIGKDLREFDCVDTGFFVLDDSIFEHAEKLRDREEIPLSEIVKLARLPVTYVDGELWMDVDTKEDVRRANRALVSAAVKGSGDGFISRKINRKISTRISAAIVNKVNPNQMTLISFLVGAFSALASFFSIPLAGLLYQFSSILDGCDGEIARASLKMSKKGGYVDSILDRFVDFLFLAIIALLYPKTATVAMFAIFGSVMVSYTSEKYKAEFGESIFGKFRVLNYIPGKRDERIFLIMIFCLLSAISLQWIFWMFLFVAAISLTRVVVTLLAVLVSK
What is the function of this protein?
Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments.  Catalyzes the condensation of CTP and L-myo-inositol-1-phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di-myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate.  The cytidylyltransferase is absolutely specific for CTP and L-myo-inositol-1-P.  The DIPP synthase uses only L-myoinositol-1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myoinositol, are recognized as alcohol donors.
What are the official names of this protein?
Bifunctional IPC transferase and DIPP synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: F166A_HUMAN
Sequence: MTTTQKHDLFTPEPHYVPGYAGFFPQLRYQVGNTYGRTTGQLLTDPSVQKSPCSVLSPMSKPKFIEDFSQSKPPRVPCQDLTEPYIPHYTSLKPSKNFEILGQLPPLEVDAQEPPGVENIPRQILLPAGFTPDTPHPPCPPGRKGDSRDLGHPVYGEEAWKSATPVCEAPRQHQLYHCQRDEYPPPARRQQETLDVGSFQRLPQLDHPNLIQRKAISGYAGFIPRFTWVMGLNYRDGVMQAMDEFDKSQFLFRNPHCDLGEKLPGTHWPSNHIYSSQGLIPFYMGFIPAMQDNYALTFGNSTRRAYWKEWAKRNHTL
What are the official names of this protein?
Protein FAM166A.
What is the protein family that this protein belongs to?
Belongs to the UPF0605 family.
Protein: DAPB_HAEI8
Sequence: MTLKIAIAGAGGRMGRQLIQAVHSAEGVELGAAFERKGSSLVGTDAGELAGIGHLGVAVSDDLESQKDKFDLLIDFTRPEGSLEHIAFCVANNKKMVIGTTGFDQNGKAAIKAASDKIAIVFASNFSVGVNLVFKLLEKAAKVMGDYCDIEVIEAHHRHKVDAPSGTALSMGEHIAKTLGRDLKTHGVFCREGITGERKRDEIGFSTIRASDVVGEHTVWFADIGERVEISHKASSRMTFANGAVRAGKWLENKANGLFDMTDVLDLNNL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH2_SYMTH
Sequence: MSSDRTREVTKRILMVLFGLWLLQFFFLPPLTTRPTELSYSAFLDALEDRRVQEAVVRDRVLQGKMVGGESFTVTLPPDAAGLAERLEEAGVEQRYEVTRTPWWVTLLPTVLWLAVMVGLFAWAQKRQAGAFGLARSTVKPLAPGESPVTFADVAGMDEVKGELEEIVDYLKNPDKYRAIGARIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFALSGSSFVELFVGMGASRVRELFAQARKNAPCIVFIDEIDAVGRQRGSAAVVGGHDEREQTLNQLLTEMDGFGAYEGVIVMAATNRPDVLDKALLRPGRFDRQIPVGPPDAAGREEILRVHAKGKQLDPSLDLAAVARRTPGFTGADLANLLNEAAILAVRRGRSHITMSEIDEAIDRVVAGGPARKGRMIRPEEKRRVAVHEAGHALVATLTPGADPVQKVTIIPRGRAGGFTLTTPEEDQMLYTRSELEARLKMLLGGLAAEEVLLGERSTGAQDDLRRATQVAREMISRYGMGQSVGLMAVPDTDWPGVQNLSQESAAAIEREVQALLDRLYREVRSLIETNRDRLVALVVELSDRETLDGDDVRRILSA
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: PILQ_NEIG1
Sequence: MNTKLTKIISGLFVATAAFQTASAGNITDIKVSSLPNKQKIVKVSFDKEIVNPTGFVTSSPARIALDFEQTGISMDQQVLEYADPLLSKISAAQNSSRARLVLNLNKPGQYNTEVRGNKVWIFINESDDTVSAPARPAVKAAPAAPAKQQAAAPFTESVVSVSAPFSPAKQQAAASAKQTNIDFRKDGKNAGIIELAALGFAGQPDISQQHDHIIVTLKNHTLPTALQRSLDVADFKTPVQKVTLKRLNNDTQLIITTTGNWELVNKSAAPGYFTFQVLPKKQNLESGGVNNAPKTFTGRKISLDFQDVEIRTILQILAKESGMNIVASDSVSGKMTLSLKDVPWDQALDLVMQARNLDMRQQGNIVNIAPRDELLAKDKAFLQAEKDIADLGALYSQNFQLKYKNVEEFRSILRLDNADTTGNRNTLVSGRGSVLIDPATNTLIVTDTRSVIEKFRKLIDELDVPAQQVMIEARIVEAADGFSRDLGVKFGATGRKKLKNETSAFGWGVNSGFGGGDKWEAQTKINLPVAAAANSISLVRAISSGALNLELSASESLSKTKTLANPRVLTQNRKEAKIESGYEIPFTVTTASGGGNSTNTELKKAVLGLTVTPNITPDGQIIMTVKINKDSPAQCASGNNTILCISTKSLNTQAMVENGGTLIVGGIYEENNGNTLTKVPLLGDIPVIGNLFKTRGKKTDRRELLIFITPRIIDTAGNSLRY
What is the function of this protein?
Required for type IV pilus biogenesis and competence.  Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA.
What are the official names of this protein?
Type IV pilus biogenesis and competence protein PilQ, Outer membrane protein Omc.
What is the protein family that this protein belongs to?
Belongs to the bacterial secretin family. PilQ subfamily.
What are the subcellular locations of this protein?
Cell outer membrane. Note=Associated to the membrane through its C-terminus.
Protein: FUS_SENDZ
Sequence: MTAYIQRSQCISTSLLVVLTTLVSCQIPRDRLSNIGVIVDEGKSLKIAGSHESRYIVLSLVPGVDFENGCGTAQVIQYKSLLNRLLIPLRDALDLQEALITVTNDTTQNAGAPQSRFFGAVIGTIALGVATSAQITAGIALAEAREAKRDIALIKESMTKTHKSIELLQNAVGEQILALKTLQDFVNDEIKPAISELGCETAALRLGIKLTQHYSELLTAFGSNFGTIGEKSLTLQALSSLYSANITEIMTTIKTGQSNIYDVIYTEQIKGTVIDVDLERYMVTLSVKIPILSEVPGVLIHKASSISYNIDGEEWYVTVPSHILSRASFLGGADITDCVESRLTYICPRDPAQLIPDSQQKCILGDTTRCPVTKVVDSLIPKFAFVNGGVVANCIASTCTCGTGRRPISQDRSKGVVFLTHDNCGLIGVNGVELYANRRGHDATWGVQNLTVGPAIAIRPIDISLNLADATNFLQDSKAELEKARKILSEVGRWYNSRETVITIIVVMVVILVVIIVIIIVLYRLRRSMLMGNPDDRIPRDTYTLEPKIRHMYTNGGFDAMAEKR
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) interacts with HN tetramer at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.
What are the official names of this protein?
Fusion glycoprotein F0, Protein F.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein. Note=Folded in the endoplasmic reticulum by the human CANX and HSPA5 chaperones.
Protein: GPIX_MOUSE
Sequence: MTTWGLLFLLWPATTDTQACPRPCTCQSLETMGLKVNCEGQGLTALPVIPAHTRQLLLANNSLRSVPPGAFDHLPQLWDLDVTHNPWHCDCSLTYLRLWLEDHMPEALMHVYCASPDLATRRPLGQLTGYELGSCGWKLPPSWAYPGVWWDVSLVAVAVLGLILLAGLLNTFTESRN
What is the function of this protein?
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels.  The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.  GP-IX may provide for membrane insertion and orientation of GP-Ib (By similarity).
What are the official names of this protein?
Platelet glycoprotein IX, GP-IX, GPIX, Glycoprotein 9.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HYPC_AZOCH
Sequence: MCLAIPVRIEELLDEQSAVACIGGLRKTINVALLDDLKVGDYVILHVGFALQKLDEAEARRTLALLAELGQLAEAEQAAQGDAS
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Involved in the biosynthesis of the Fe(CN)(2)CO cofactor.
What are the official names of this protein?
Hydrogenase maturation factor HypC.
What is the protein family that this protein belongs to?
Belongs to the HupF/HypC family.
Protein: HIS52_CAMJE
Sequence: MKIIIIDTACANLASLKFCLDRLGFNATISRDLKELESADKLFLPGVGTAKEAMKNLEQFNLIDFIQNTKKPLLGICLGMQILGNFSEELNQETLKLIDFTTQKFKAKEGFTFPHMGWNEVYSSHALFKGLEGAYFYFVHSYCVGLGKYTIADCEYSQKFSASVMKDNFYGVQFHPERSSEAGEILISNFIKDIG
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH 2, IGP synthase glutaminase subunit 2, IGP synthase subunit HisH 2, ImGP synthase subunit HisH 2, IGPS subunit HisH 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_SYNY3
Sequence: MNNQQLWQRYQDWLYYHGGLDFYLDVSRMGFSDALVEDLQPKFAKAFQDMVALEKGAIANPDEQRMVGHYWLRNPALAPNDGIRAEITEPLRQIKAFVADVHQGNIKPPTAPKFTDLLAIGIGGSALGPQFVAQALAPNFPPLAIHFIDNSDPDGIDRVLNCLKAQDKLKSTLVVTTSKSGGTPEPRNGLAETKAVFEAQGLHFADYAVAVTMPGSKLSQQAQTEQWLQAFPMQDWVGGRTSELSAVGLLPAALQGIDIQAMLDGAKTMDEATRVRELRQNPAALLALAWYYAGDGQGKKDMVILPYKDRLLLFSRYLQQLVMESLGKERDLDGNVVHQGIAVYGNKGSTDQHAYVQQLRDGVPNFFATFIEVLHDRQGPSLELEPGVTSGDYLSGFLQGTRQALFENQRDSITVTIPEVDATSVGALIALYERAVSFYGSLVNVNAYHQPGVEAGKKAAASILELQKAILSTLQNESGPIALEALATKVQAPEQVETVYKIVRHLAANDRGVTLQGDRQFPQRLQIQWRS
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_BURO1
Sequence: MTSETSVNLLDFDAEGLVAYCGSLGEKPFRAKQLQRWIHQYNAGDFDGMTDLAKSLREKLKGRASIVMPDIASDHVSTDGTRKWLIDVGNGNAVETVFIPEETRGTLCVSSQAGCAVNCRFCSTGKQGFSRNLSTAEIIGQLRMAEFALRASLGRAPGPNGKAERVVTNVVMMGMGEPLLNYSAVVPAMRLMLDDNAYGLSRRRVTLSTSGVVPMMDRLGAELPVALAVSLHAPNDALRDELVPLNKKYPLRELMAACQRYLKVAPRDFITFEYCMLDGVNDTEAHARELLAVTRDVPCKFNLIPFNPFPESGLIRSKPEQIKRFAQVLIDAGVVTTVRKTRGDDIDAACGQLAGAVKDRTRLAERTGAAGKIIEVRAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
Protein: MED18_ASPCL
Sequence: MHELLLFASVPAHQHHELLQQLAGLTAMQPQHRFERRLIFKAYRKPGLVNVRVGASQDVQGAEMQRLNKMLNGGMFYTQVVGPVAAADFGAPAPTVSVGDQDAQMSGMGVGVSAGVDEKPSTRPHRYDYDDQPWKLEFRDIPEAGTRSAVTARLMASASLPRGDIMVPMNAWGYNFVTEYAVEGDIFILHDIVIFLHRVLHYPTESQEPRRQLPALPEMTPLERSGSYVLQAAITVQDGASQETMKIASQHLFGLREQLKSAVRLEMADRLSLDTRAK
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 18, Mediator complex subunit 18.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DUT_HELPJ
Sequence: MKIKIQKIHPNALIPKYQTEGSSGFDLHAVEEVVIKPHSVGLVRIGICLSLEVGYELQVRTRSGLALNHQVMVLNSPGTVDNDYRGEIKVILANLSDKDFKVQVGDRIAQGVVQKTYKAEFIECEQLDETSRGSGGFGSTGVSKA
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: SYP_CHLAB
Sequence: MKTSQLFYKTSKNANKEASVLSYELLEKAGYIFKTAKGIYTYTPLFWRVALKMMDIIREELNAIGGQELVLPILHPAELWQKTGRWEAFRSEGLLYTVKDREDKEFCLAPTHEEIVSMFVSQWLSGRKQLPIHLYQIATKFRDEIRPRFGLMRAKEFLMEDSYTFSDSPEQMNEQYAKLRQAYQNIFDRLEIQYVIVEADGGKIGKGKSEEFHVLSSLGEDTLCVSGHYGANIEAAVAQPPQYTYDKDYLPIEEVDTPDVRTIENLQDFFSVPPYRIMKTLVVKLSYGEKEKFTAIGIRGDRQINLTKIGSKLNADACSLASDEEIQKHLGVEKGFIGPLNCPIDFYADETTQCMTNFICAGNVKDKHYKNVNWDRDIPRPEYADFLLAEAGDLCPTNNHAPYEIFEGVEVAHIFNLGTRYTEGFDVVFQDEQGKPQSCWMGTYGIGIGRTLAACIEQLADDRGIVWPKAIAPFDISILYNGGDTACEEAAEKIYKELQGYGYAPLLDDRNERLGFKLKDSDLIGIPYKLILGKTFLNSGMLEIESRSIEKFSVEPKDFVHWCKRHLPSPRVFSPIP
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_THENN
Sequence: MPNTKSAKKRVRVSEKRRLRNKAYKTFFKNRIKEVIKAIENGEPKEVVLELARKAQAAIDKAVSKGVIHKNQGARRKERLFKRVNEYLKSLEAAETTQE
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.