PharMolix/UniProtQA huggingface dataset:
Protein: SMG1_DICDI
Sequence: MNDSNSSNDSCNTENNTLTATKNSINNTTTTTTTPNNNVNCLKTSGSIKLSASSVPFIPGSSASLPSILSNQYKLAASNNVSNNIMMISTPIISSAQQQQQQVPPPQQTTTTTTATATAITPTPITTSQSTSSSMLNLPLKVGKESIETLFRNRFHPKNNIRETVLSSLQSILIPDLSDTINNTKENIEYFYNMIIDENNYILKLLLLNIINDTKRNLVVYNYNQQHQLPIQNTSSPNTPSSTTTTTTTSTKPSKRGDKERERGRRNKDKINEKQLQQQQLQQLQLQQQLDHEGSSLYLPFSSLLSFIKPDKQQQPQQSQQSQLNEIDQMVRPKSLPKDDNDSDNFNIRVLEYNLKLLIKIYFKVSMYQDSIKTHIFDLYIQINQAISEQQRQLQEKEKESKTSKPIPQPIISLVIPTVLVSIGDIIKYKYATPSPPNLTPTTTTKMEEEERIINTILINEFKKTDVSIIESNLYLFECILSISVSNEPTIVVPNTTTATTATTATTSNTSTAAAATTTTPTLSTSSSSLSPPASTQSSLSLSSSSSAVIAPTTVGYIFKFNKELFRKLIALVYSTVVQHQITLSTVFTTLVLKGYLNEDQIQKLLNITLFKLSDPSEQVKLSYLTLLSKMVSYFDLNHQKNLNHKVNDISLPYKLLIMGSTSQPFFNGQIFKKIFDWIMGIGKDQPSFDSLTKYLIDLFDSFNVISILFNEQNKILSQQYLAAQSTMITPPLSLHQIDDRRKFETLISKSDELIWFWTVWECSKFCIANRLKSPYGSAFQTFEIFEKLLLQLNKDRRDFKKIKILLHFMESMEKLIFSTVNGSVLVQSLNNKETQFFRHNVRVCEDWFSRIRVNLLKASILSSSTPDIIRHASLRVQDIQANRFVLDSNTAHFELEFCILHLANALQQLNETESLQGLSNWSDINLNNSDNNNNNNNKNNNNNNNSTFFNNGNINKYTLKLPWMKGVILRSKQKFEESISSLLSVPPMLESNSISFPFVLEQIIKSYLDISNFTEVEQFLQNYQNQIQQQSNSLIIYKDTFIKTLGSFYRGEMEEAHAFAKRTESQNHILQREQLGLGLLGNQIMTDELLLSIMVNQKDLFNNTNIINNNNSGGSSSGTATATAVTTTTTTTTTTTTTTTTTTNTNNDIIGFSNNINSMLKLTKNNILKALNYLGLESNVQTFQYLTQLKIMDEIENGVYNSRVVPINNQIGFLERLRRVRGHISNTKQRSDILLSNIPLTEKMIKLSRKFENYKFSSKLLDTILESHSSSYYLERCKLKYLNGKQTEATLDLIKYAHRDITIPSSSTTTTTTTTTTTPPSTSSNTATTTNNINIDELSTQKFKVYTEIIKYLNSNPSIITELSSSNYSIPQEQLNPEYYFKKATLTKPENSKLWITYADWILNEKSNISEQNDEESLNGGGSGGNENSSNEMLRLKNTNTNELKTAVEAYFQFLKYSMLDGNSNGGLNIRATLKILNILVCSGNKLVETFERCLNELTSTRPFTIIIPQLFARLSHPDTFVQKYVVEILNRIGRDNPNKIVYQTIVGSLNFTNTNNNNNSSCAAATTDDGLDIELLQKQYPNYLQILNIKENLLKHSELLVKETETLIYQLGKLTTLWDDNWQYFIEQIQGWVYINTKQWNDDYQQLKATIKNPTILKHTLKKKNQELLQPIYEKLKRLTAATVLSVCKTPHEKWFTKCHFETINKTIRAFEKQNKPTSPFDVLHDLIAEFQQYRLISLSLSSVNPSLALFRPTITQMPGTDLNYFNINHIHHHHHHHNHHGNNNNQHSTSSGNLPIQNQVTIQLIKPTIYLLPTKTKPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYKNWYKNDQVYKQQQQQQQQLQQQQQQQQQQQQQQPQPQQQPQQQPQQQPQQQPQPQQNSTTTSNIVNKPIIARPVDIFYAKITPLLEKAGLNFMTPRSEWPKEILIQVLNELMQETPKWILQRELWFSSSSSSELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAELKIPERVPFRMTQIFEYALGLTGVQGTFRETSIQIMHLLRKNKDILLNLLETFIYDPLFDWKHSNKQTNNNNNNNNNNNMNQAAGEQESIEKKQSSNNSSNPIISTPTKLQQQQKLPNSPLSISSNNTNSTNNNNNNNNNNNNNNNNNNNNNNKDQDSDSSQSQEDEDNNVVEGEGGEGGEGDIDELNLVQDSSNGKDAFKSIQGLTVVNQVRLKLEGTEKKLSIPDQIDLIIRESMNVENLSSTYEGWSPWV
What is the function of this protein?
Serine/threonine protein kinase involved in mRNA surveillance.  Recognizes the substrate consensus sequence [ST]-Q.  Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating upf1 (By similarity).
What are the official names of this protein?
Probable serine/threonine-protein kinase smg1, Suppressor with morphological effect on genitalia protein 1.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
Protein: ATPD_IDILO
Sequence: MSELTTVARPYAKAAFDFALEQGALDKWAEMLSFAAAVAQDETIASFLSSSSTVGKTTEVFLGVCGDELDDNAKNFVKVLAENERLPVLPAVSELYQTLRAEHDKEVTVDVKSAVKLLKAQQTALIKALEKRLQRKIKLNCSVDKSIIGGLVIEAGDTVIDGTLRGKLDRLAYALQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS16_DESAP
Sequence: MAVKIRLKRMGAKRDPFYRIVVSDARSPRDGRFIEQIGYYDPLEEPARISVDEAKARVWLQQGAQMTETVRSLFKKSGVLERLGAERAEERG
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: LCDH_STAES
Sequence: MKFAVVGTGVIGSGWITRMLAHGHEVIATDPSEGAYERMLTQVKQNWPYAEQMGLAENASIQNLTFTPHLEEAVKDADHIQENVPEVEEIKDAVLKEIDFYAKPEATIGSSTSGIMPSELQANLSHPERLVVAHPFHPVYILPLVEIVPGKQTSEETTVKAEQIYESIGMDVLHVRHEIEGHIADRLMEALWRESLHIVNDGIATTEEVDKAFTHAAGLRYAQYGPFMTFHLAGGEGGMRHMLKQFGPALKKPWTKLIAPELTDDLYHKVVSGSEASSQGYTMSELDQKRNEFLIKVKELAEQYWPSDSKAMKKSNGAELQ
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.
What are the official names of this protein?
L-carnitine dehydrogenase, CDH, L-CDH.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM61_DICDI
Sequence: MLNPNKIIKEGDRVVMYNGKDNMAVLTMESNNVYNSKFGSYRHKNIIGKEYGSKLSSDNGNGFCHVIAMTPELWSITLDHRTQILFNLDISTIIFNLELKNGSRAVESGTGSGSLSSSIARTIAPKGHLFTFEFHEERVKFARKDFKDNGLDQYITVTHRDACGKEGFLRQDINNDIDAVFLDLPSPWDAIENAIAVMHDGSMLCSFSPCIEQVQNTCLKLADSKFQEIKTIEVLIRTFDTRLQEYEELNLTNPYIDNNNNNNNNNNIEENRGKFEIGGIEGLKKDKLLSKPFTEARGHTGYLTFARYLPNA
What is the function of this protein?
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
What are the official names of this protein?
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trmt61a, tRNA(m1A58)-methyltransferase subunit trmt61A, tRNA(m1A58)MTase subunit trmt61A.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UNG_HELPH
Sequence: MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPSAVKIILLGQDPYHSTYLENQQELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVSVPCCGDLSAWAKRGMLLLNAILSVEKNKAASHKRIGWEAFSDQILMRLFEANAPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAYREVYHKDFDFSL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFB5_NEUCR
Sequence: MPRAIRGVLIQCEPAIKSIIVHLDSVNNDIIIEDLDEQTLVVKENMVQLLKQKLEDRLKETYRPEEPLADSD
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH subunit rtf-1, TFIIH subunit rtf-1, RNA polymerase II transcription factor B subunit 5, RNA polymerase transcription factor-1.
What is the protein family that this protein belongs to?
Belongs to the TFB5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PHEA2_CHRS2
Sequence: MIAKTVAILALAGSAAAYAPTMSLSANRRELVQGAAAAAVVAPMLRPTGASAKDAQLRAPVVTIFDARGCKDHANKEYTDPKAGNAENDECCVKVQMTPIKVADDAAALVLKECLSELKGKK
What is the function of this protein?
Light-harvesting photosynthetic tetrapyrrole chromophore-protein from the phycobiliprotein complex.
What are the official names of this protein?
Phycocyanin PC645 alpha-2 subunit, PC645A2.
What is the protein family that this protein belongs to?
Belongs to the phycoerythrin family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side.
Protein: ADH2_EMENI
Sequence: MAAPEIPKKQKAVIYDNPGTVSTKVVELDVPEPGDNEVLINLTHSGVCHSDFGIMTNTWKILPFPTQPGQVGGHEGVGKVVKLGAGAEASGLKIGDRVGVKWISSACGQCPPCQDGADGLCFNQKVSGYYTPGTFQQYVLGPAQYVTPIPDGLPSAEAAPLLCAGVTVYASLKRSKAQPGQWIVISGAGGGLGHLAVQIAAKGMGLRVIGVDHGSKEELVKASGAEHFVDITKFPTGDKFEAISSHVKSLTTKGLGAHAVIVCTASNIAYAQSLLFLRYNGTMVCVGIPENEPQAIASAYPGLFIQKHVHVTGSAVGNRNEAIETMEFAARGVIKAHFREEKMEALTEIFKEMEEGKLQGRVVLDLS
What are the official names of this protein?
Alcohol dehydrogenase 2, Alcohol dehydrogenase II, ADH II.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRS_DROME
Sequence: MFRSSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIVKNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQYLMGQSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVPGYLPQGPAPAPNGHGQFQAIPPGMYNPAIQQPMPPNLQPGGLMQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQHSIAQPPQIPFQPQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPVQQPQPQPQMGHVMLQQHQAPPAAQAPPVTEIANNQVQAVAAAPAPPQNEPGPAPVKAEEPATAELISFD
What is the function of this protein?
Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs.  Required during gastrulation and appears to regulate early embryonic signaling pathways.  Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs.  The MVBs are then trafficked to the lysosome where their contents are degraded.
What are the official names of this protein?
Hepatocyte growth factor-regulated tyrosine kinase substrate.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Note=Locates to vesicles present in the perinuclear regions of muscle cells and in the periphery of Garland cells of third-instar larvae.
Protein: RNH2_XANCB
Sequence: MTRSSSDRAIVVPAAQNALFTDSPFPTPDSRLIAGVDEAGRGPLAGPVAVAAVVFDPAKPRINGLDDSKQLSAERREQLYARIVDRALAWSVVLIDSEEIDRINIYQATMLGMRRAVEGVAHVAGFARIDGNRVPKGLPFPAEALIGGDALDRAIMAASIVAKVTRDRLMRELHAQHPEYRFDLHKGYSTPAHLAALQTHGPCPQHRRSFAPVRRALGLETAQTAWDVPCAPADGLLLAE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_PSEA8
Sequence: MSSGRIVQIIGAVIDVEFPRDAVPSIYEALKVQGVETTLEVQQQLGDGVVRSIAMGSTEGLKRGLNVDSTGAAISVPVGKATLGRIMDVLGNPIDEAGPIGEEERWGIHREAPSYADQAGGNELLETGIKVIDLVCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMKDSNVLDKVALVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLLFIDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKKGSITSIQAVYVPADDLTDPSPATTFAHLDATVVLSRDIASLGIYPAVDPLDSTSRQLDPLVIGQDHYDTARGVQYVLQRYKELKDIIAILGMDELSEADKLLVARARKIQRFLSQPFFVAEVFTGSPGKYVSLKDTIAGFKGILNGDYDHLPEQAFYMVGGIEEAVEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SC16B_MOUSE
Sequence: MEPWVPQTQGRTTGPSRDTNRGLQSGHYRPRLHSQYSGDKYHQWQDAHKNSKSQQDLRDDHQQSHSVSRSGEWSQPVSGADYLKGSYPSHLYSRSGYGDPYQRYHTPTPRDEYAYGNYYYHGHPQLLPEERVARQGSPYIWHEDHGDQRYFGEHHREKHNGTFGANSDTQFQFTSKNPYRDSPASVSGQEQPGEFFPESEAQKQKPLLTSKSSLLQQHESGLSSSSYELSQYMTAAPEEYEPMVSAAWRPIQADDTSATVPKAPMRFYVPHVSVSFGPGGQLVCVPPNSPADGQTALVEVHSMEVLLNDFEDQEEMRAFPGPLIREDIHKVDIMTFCQQKATQCLKSETPGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLSSGTRDLLTGEIPPNVDTPAQIVEKFTKLLYYGRKKEALEWAMKNHLWGHALFLASKMDPRTYNWVMSGFTSTLALNDPLQTLFQLMSGRIPQAATVCGDKQWGDWRPHLAVILSNQAGDTELYQRAIVSMGDTLAGKGLVEASHFCYLMAHVPFGHYTVKTDHLALVGSSHSQEFMKFATIEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLASQALHYCEAIGAAVLSQEGSSHPVLLAELIKLAEKLKLSDPLVLERRRGDRDLEPDWLVQLRRKHKDLEQNRTGAPRDPDSTPSDIYGAGGTTDTPYPDLSGHQNYSEDSEYSSTLWSTAEQTSLTNPLAQQSFPLQRDTYSGHMGTPVPLYSVPATHLAVTSGASGSSVAVTGTPGGRVGEDMLRTHPAFGENTMTQEPLEDPDGLEVISSLQTPAAPRVPSFSEDSAASAKEDEEGSSDGADKPSHPDASQKGKLGDGKNTKSSGFGWFSWFRSKPASSVSTSGDEDSSDSSDSEESPRASSPHHASPGLSPTPPLTSPSLPGASTFSRGTGGSILQGSSNSSGIAEGMGIGGFSGTQGVSSEFYSQPGALPPPPTLQGAVPLYNPSQVPQLPTASSLNRPNRLAQRRYPTQPC
What is the function of this protein?
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).  Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.  Involved in peroxisome biogenesis.  Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes.
What are the official names of this protein?
Protein transport protein Sec16B, Leucine zipper transcription regulator 2, Regucalcin gene promoter region-related protein p117, RGPR-p117, SEC16 homolog B.
What is the protein family that this protein belongs to?
Belongs to the SEC16 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).
Protein: ATPF2_MOUSE
Sequence: MWRIYPRLRDRWRGLLDRRLSDPTVSVWPGPAPQPPARAYVPPTERKRFYQNVSISQGEGGFEINLDHRKLKTPQAKLFTVPSEALAIAVATEWDSQQDTIKFYTMHLTTLCNTSLDNPTQRSKDQLIRAAVKFLDTDTICYRVEEPETLVELQKNEWDPVIEWAEKRYGMEIGSSTSIMGPSIPTQTREVLTSHLSSYNMWALQGIEFVVAQLKSMLLTLGLIDLRLTVEQAVLLSRLEEEYQIQKWGNIEWAHDYELQELRARTAAGTLFVHLCSESSTVKHKLLQE
What is the function of this protein?
May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase).
What are the official names of this protein?
ATP synthase mitochondrial F1 complex assembly factor 2.
What is the protein family that this protein belongs to?
Belongs to the ATP12 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL35_LISMC
Sequence: MPKMKTHRGSAKRFKRTGSGKLKRRHGFTSHMFANKSQKQKRKLRKSAMVSAGDFKRIRQMVAKMK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: NAF1D_ORYSI
Sequence: MNEEVEDGEVKPLELSSEDKAILVETLKNKLQALAEQHVDVLESLAPSVRKRVDVLMEIQSQHDELEVKFFEEKAALEAKYQKLYGPLYSKRSKIVSGVLEVEGETEEREEKGVPDFWLNAMKNNEILAEEIHESDEEALKYLKDIKWCRIDDPKGFKFEFFFYTNPFFKNQVLTKTYHMIDEDDEPILEKAIGTEIEWHPGYCLTQEVLTKESSESTKPITKTEECESFFNFFSPPQVPDDDAKIDENTAEELQNQMERDYDIASTLRDKIIPHAVSWFTREAVQDEDYGASWVDDEEEDDNDDEYSDEEA
What is the function of this protein?
May modulate chromatin structure by regulation of nucleosome assembly/disassembly.
What are the official names of this protein?
Nucleosome assembly protein 1-like 4.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: FOLM_ECO57
Sequence: MGKTQPLPILITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLINAGAQCIQADFSTNDGVMAFADEVLKSTHGLRAILHNASAWMAEKPGAPLADVLACMMQIHVNTPYLLNHALERLLRGHGHAASDIIHFTDYVVERGSDKHIAYAASKAALDNMTRSFARKLAPEVKVNSIAPSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIDLVDYLLTSCFVTGRSFPLDGGRHLR
What is the function of this protein?
Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin.  Also has lower activity with dihydrofolate.
What are the official names of this protein?
Dihydromonapterin reductase, H(2)-MPt reductase, Dihydrofolate reductase, DHFR.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily.
Protein: RL14_MYCUA
Sequence: MIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDIIVATVKDAIPGGNVKRGDVVKAVVVRTVKERRRPDGSYIKFDENAAVIIKPDNDPRGTRIFGPVGRELREKRFMKLISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: INTU_DANRE
Sequence: MFSTCSDGRPFQSFSTNLEDFDSIRSVLLYSDLEPEWLDDVQKNGQLFYLELSDGEEEALLAQVSANHSAATNHVRFSEKEAEIITDNAKRQANSSNKSEAKLKKLTKILRRKRRPSQRKAEGKDSSQRPASILKNQAGQRPGVVVQQQRLKDVCVYLNPKRLSSVSSSSADRGGLLEALLGVVHRPGGNTGKRGGKLIIHGLIPHSPASKCAEILIGDALVAVDDVEVTSENIERVLSCIPGPMQVRLTLETVCPAGVSPESKVSASPQVSQLVRLLWGEDTIELQMSIADVPHIAMFLSLRLDSETQQDEQEIVYQYPQSEASAQLKAVRGIFLTLCDMLENVTGGQIISSSLWLQQQLVHVGYWKEESNLLVIAVPASRVPLLYLQTVIEGVVRTLKVMYGSLDRGFSDVENAPRLDHFFCLFFQQLIQPSRLIHSSRTPDLYGSLFLDGLPAVRWLTLPPDIKVEVDTVLSDFESSDFGDMSEDFYGMRRLYVILGSCLFYKGYLIANHLPKEDLLDVCLYCQHYCLLPLASEQRVAQLVVWREVFPQRRETRNSTAHPGYCQPHARHFLLIVGLRHFMQCVLLEAGGCASSAVGRPTPDSVYVDQVKATLLQLESLDAGIEERLSAPPTPCLSCADWFLPAGGRSQQDTIGSSPILNRLTAAIKPPSPGGIGRSLFGEAGTVGIRGRRASPQRSQSDSGSEGHADGTPASVARRDSLGSGGSDGSLGSAGFLKMPRLKHPNPFYLGSLRKSLSERETEEMQNVLQVTAGVENTLFHYVLMESVQGIFIAPTHTEIRHLSGSIHPQLIHNFQHCCLSIRQAFQQSLPTRDRRGPERQSTAGLGPVKEHGVLFQCKPQNWTDQKKPAPTMTYWVIGRMLLEPVPQEFYVCFHDSVAEVPVEMAFRLSFGLAV
What is the function of this protein?
Plays a key role in ciliogenesis and embryonic development.  Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules.  Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension.  Has an indirect effect on hedgehog signaling (By similarity).
What are the official names of this protein?
Protein inturned, Inturned planar cell polarity effector homolog.
What is the protein family that this protein belongs to?
Belongs to the inturned family.
What are the subcellular locations of this protein?
Cytoplasm. Cell surface. Cytoplasm, cytoskeleton, cilium basal body. Note=Enriched at the apical surface in ciliated cells.
Protein: DTD_SHESA
Sequence: MIALIQRVSRASVVVDNQTIGAIDKGLLVLLGVEREDNREKMEKLATKVMSYRVFSDENGKMNLNLTQAGGSLLVVSQFTLAADTGRGLRPSFSGAGTPEQALGLYEDFVAFCRAQGVTTETGQFGADMKVELINDGPVTFNLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_SERP5
Sequence: MAKQSMKAREVVRVKLAEKYRAKREELKAIISGVNSSDEDRWDAVLKLQTLPRDSSPSRQRKRCRQTGRPHGYVGKFGLSRIKLREAAMRGEVPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: PTH_ERWT9
Sequence: MSRIKLIVGLANPGAEYAATRHNAGAWYADLLAERHNQSLKEESKFFGFTARLNLGGEDVRLLVPTTFMNLSGKAVAAMATFYRIPAEEILVAHDELDLPPGVAKFKQGGGHGGHNGLKDIISRLGNNQNFHRLRIGIGHPGDRQKVVGFVLGKPQAAEQRLIDDAVDEAVRCTEVWMKEDRLKAMNRLHSFKAG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3HAO_RUEPO
Sequence: MARLSAFNFQKWIDEHKHLLKPPVGNQQVWEDADLMVTVVGGPNKRTDYHDDPVEEFFYQLKGDMVLKLYEGGEFYDVPIREGDIFLLPPHVRHSPQRPQEGSIGLVIEPKRPEGAHDAIEWFCFGCGSLVHRAELLLESIVRDLPPVYQAFYADEQARTCPNCGEIHPGKEPPEGWVKL
What is the function of this protein?
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
What are the official names of this protein?
3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HAD.
What is the protein family that this protein belongs to?
Belongs to the 3-HAO family.
Protein: PG142_MONPV
Sequence: MFVDDNSLIIYSTWPSTLSDSSGRVIIMPDNRSFTFKEGFKLDESIKSILLVNPSSIDLLKIRVYKHRIKWMGDIFVLFEQENIPPPFRLVNDK
What is the function of this protein?
Late protein which is a part of a large complex required for early virion morphogenesis.  This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions.  Required for the stability and kinase activity of OPG054.
What are the official names of this protein?
Core protein OPG142.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG142 family.
Protein: EIF3E_MONBE
Sequence: MAAHDLTQAICQNLDPHLILPLLDHCVDLDIYNEADLKRAKMQVLSRTRLIEQALELADATEKKDLDARMRSISEEEKTWEKQLEPVFEMFENDEVLSIIEATKNKDSLLSELEPYGFTENTADLLYHGSKFYFDRGQYDLAHGLLYNYRAVSTDDKLKFTALWGKLAAAILSGNWQTAQEDMYLLLEYIDGGKNELTAVEQLQQRNWLLHWSLFVFFNQPDGPDGIVDLFMNKETCTNAMQTIAPHLFRYATAVAIMSRRKKRDVMWEFVGIARQDKDLGDDPVVGFLVSLIKDFDFVTAEEKLQQCREVLSKDYFLAEMTDEFINTAQLYLFEVYLRVHSRVSIKNAATRLGKSEDDAEEWLVKLIRDAKLDAQIDPASGEIHITKPVTTVYQHVLDRTKNLQYRTYVIVESLHHLHPNGAFHHSNSSIPALFRRMMNEQLQGGGKSNKKGDYKKGDYKKGGDFKKGGDFKKGGDHKKRAWVK
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E, eIF3e, Eukaryotic translation initiation factor 3 subunit 6.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm.