PharMolix/UniProtQA huggingface dataset:
Protein: RS8_BORA1
Sequence: MSMSDPIADMLTRIRNAQQVDKTTVNMPSSKLKVAIATVLKDEGYIDSFEVKGSQAKPELEITLKYYAGRPVIERIERVSRPGLRIYKGRSNIPQVMNGLGVAIVSTSRGVMTDRKARANGVGGEVLCYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NU1M_PTEGI
Sequence: MFMVNLLTMIVPILLAVAFLTLIERKVLGYMQLRKGPNVVGPYGLLQPMADALKLFIKEPLRPLTSSPSMFIIAPILALTLALTMWIPLPMPHPLINMNLAVLFMLAMSSLAVYSILWSGWASNSKYALIGAMRAVAQTISYEVTLAIILLSVLLLSGSFSLSTLITTQEHTWLMLSSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAGGPFALFFMAEYANIIMMNTLTAILFTGAFHNPLMPELYTINLIIKALLLTVFFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVAMPITMAGIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: THIC_AZOSB
Sequence: MNAKEHFIATEAKVDEAAIAPLPNSRKIYVEGSRPDIRVPMREIRQSDTPASFGAEPNPPIFVYDCSGPYTDPAAKIDIRSGLPALRAGWIAERGDTEQLADLSSEYGRQRAADPRLDELRFPGLHRKPLRARAGANVTQMHYARRGIVTPEMEYIAIRENLRRKDYLESLLAAGPTGQKMAALLTRQHPGQNFGAAIPNEITPEFVRDEVARGRAIIPANINHPETEPMIIGRNFLVKINANIGNSALGSSIAEEVDKMTWSIRWGGDTVMDLSTGKNIHETREWIIRNSPVPIGTVPIYQALEKVDGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYIPLTANRMTGIVSRGGSIMAKWCLAHHKESFLYTHFEDICEIMKAYDVAFSLGDGLRPGSIYDANDEAQLGELKTLGELTDIAWKHDVQVMIEGPGHVPLHMIKENMDLQLEQCKEAPFYTLGPLTTDIAPGYDHITSGIGAATIGWYGTAMLCYVTPKEHLGLPNKQDVKEGIITYKLAAHAADLAKGHPGAQIRDNALSKARFEFRWEDQFNLGLDPDKAKEFHDETLPKESAKVAHFCSMCGPHFCSMKITQDVRDFAAQQGVDEAEALQKGMEVKAVEFVKSGAEVYRNV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: DAPF_CAUSK
Sequence: MSRTFLKMNGLGNDFVVIETLTQPFHPTAEEIRAIAKRPNAKEGEGGIGCDQVIAIDPPRAEGASAYVRFWNSDGEETGACGNGTRCVAWLLMQSGQKDSVAFDTVAGRLSGKMAGDKLVTVDMGQPGLAWNQIPLAEEMDTVGIELQVGPIDAPLVHTPGCVSMGNPHVVFFVDAPVSDAFARGTGSLVEHHPLFPEGVNVGFAHIAARDHIKLKVWERGAGLTAACGTGACAAQVAAVRRGLTDRVAKVEFESGALTIEWREADGHVIMTGPVTMEFVGKLPEKVAA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAA_STRPG
Sequence: MSNEFINFEKISRESWKTLHQKAKALLTQEELKSITSLNDNISINDVIDIYLPLINLIQVYKIAQENLSFSKSLFLKKDIQLRPFIIGISGSVAVGKSTTSRLLQLLLSRTHPNSQVELVTTDGFLYPNQFLIEQGLLNRKGFPESYNMELLLDFLDSIKNGQTAFAPVYSHDIYDIIPNQKQSFNNPDFLIVEGINVFQNQQNNRLYMSDYFDFSIYIDADSSHIETWYIERFLSILKLAKRDPHNYYAQYAQLPRSEAIAFARNVWKNVNLENLEKFIEPTRNRAELILHKSADHKIDEIYLKK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_SYNS3
Sequence: MLQYQIDRIEHQITDDRSQTGVFLIGPLERGQATTLGNSLRRMLMGNLAGTAVTAVRIAGVNHEYATIPGVREDVLDILLNCKQLTVTSRTDELEIGRLIVSGPAVVKAKDLQFSSQVQVVDGERPIATVSEGHSLELEVHVERGVGYRPVDRHNEDTSAIDLLQIDAVFMPVHRVNFTTDETAVAEGGSARERLRMEVVTDGSMTPDDAIAQAANQLIELFQPLATVTMVEEPGIEPEPSAEAQIPLEELNLSVRAYNCLKRAQVNSVSDLMGFSYEDLLEIKNFGSKSADEVIEALERIGISIPQSRTSV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: EX7L_SHEB5
Sequence: MQGTKNNIYTVSRLNGEVRQILEGQLGKIWLNGEISNFSSPSSGHWYLTLKDHSSQIRCAMFKGRNQTVSFKPINGQQVLVKGAISVYEPRGDYQLLIESMLPAGDGLLAQQFDALKMKLAAEGLFAADTKRPLPKNIQRIGVITSPTGAAIRDVLHVLARRDPSIEVIIYPTQVQGETAAQSICQAINIANQRLEVDVLLLTRGGGSLEDLWCFNSEALAHTIYNSALPVVSAVGHEVDTTISDYVADIRAPTPSAGAELLSQDSDNKAQKLATALSRLQQSAKHYQLKQERRLSLLEHRLQRQDPKRTLQQFEQRFDEMQLRLESALLNRLHILSRRQQLLASRLEQQSPKHKLTIEGNRLSYLASRLQDALQDKLSQSEQRIKYAAHQLETVSPLATLSRGYSITTDIHNQVVDSADKLTIGDSLQTRLRHGQVISTVTQIKPLE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CL16A_DROME
Sequence: MFRSRSWFGGPWGGRPKNRLSLEHLKYLYSILEKNTTVSESNRGLLVESLRCIAEILIWGDQHDSLVFDFFLEKNMLSYFLHIMRQKSGGSSFVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIMVHKFDFSDEDVMGYYILFLKTLSLKLNTHTIHFFYNEHTNDFPLYTEAIKFFNHPESMVRIAVRTISLNVYKVQNPSMLRFIRDKTAAPYFSNLVWFIGKHILELDTCVRTDIDHQSNQKLSNLVAEHLDHLHYLSDILLLEIKDLNAVLTEHLLHKLFVPLYIFSLTPAPPPPSLAVVTQNLAAVLNRNVDIDIQEMHNPRVSSIVALFLLSLVFLVVSHAPLVHALAWVILNGDHSVFKEGAAEILNSYVEHREVVVPGFGEPDESLEQALDTVTGQSSSSSYALSEDSGVESSSPATTELDSQADAVEAEQIKLRNITDEEKQLLQKSSSSTKADFAEMAKPFLDTVLHALDCTENDYLALLSLCLIYAMSHNRGIKNEWFEQVLAKSTRGAFSYKTALIEHLLNIITQSSQPSSRIRLITVEIALELLVTFTRPSSDDSRCITAAQQDLLFSARNQSMVVIRNFYKSEDIFLDLFEDEYNEMRKAQLNVEFLCMDSTILLPPTGTPLTGINFTRRLPCGEVEKARRAIRVYFLLRRTCQKFLNEKESLLPLTNVVNLVQVENVLDLNNSDLIACTVVAKDSSKQRRFLVIDALQLILVEPDAKLLGWGVAKFVGFLQDVEVQGDKDDSRCLHITVHRGGVTHNRTPLLSAKFLFDDHIRCMAAKQRLTKGRSKARQKKMYQIAQLIEIPGQMDSPVYAVGGTMVASSSGGSGNSSGSSSRSSHHRPMFSTANRVPGFAAVLRGSNSAGVSRTQMAPNRSIEGIRNESAGRSRRRSPSSTSGSNLRADHSDRERSPSVSMGSHSSSQSRENSQPRSTGNRSRESSPRMPRPRSEEIPLEDFQHSRNNSPHSRGNPSPASRSHTPIRVLHYDQLSGHSGSPREASLGGTNALLSQLNGLNREVLPTQSSEETSFIGSDGNEATGGSEGRRRGAIETV
What is the function of this protein?
Required for mitophagy, autophagy and endosome maturation, possibly by acting in multiple membrane trafficking pathways (PubMed:20194640, PubMed:22493244).  Required for endosome trafficking and maturation (PubMed:20194640).  Functions with the class C Vps-HOPS complex member Vps16a to promote endosomal maturation into degradative late endosomes and lysosomes (PubMed:20194640).  In response to starvation, functions at an early stage of autophagy to promote autophagosome growth and efficient autophagy (PubMed:22493244).  Essential for the recruitment of lva-positive Golgi elements to autophagosomes (PubMed:22493244).  Likely to function by promoting membrane traffic from the Golgi complex to the developing autophagosomes (PubMed:22493244).  Also regulates synaptic growth at the neuromuscular junctions (NMJ) by down-regulating BMP signaling (PubMed:20194640).
What are the official names of this protein?
Protein CLEC16A homolog, Endosomal maturation defective protein.
What is the protein family that this protein belongs to?
Belongs to the CLEC16A/gop-1 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Single-pass membrane protein. Late endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Note=Under normal conditions detected in small punctate structures throughout the cytosol of fat body cells, upon induction of autophagy by starvation becomes localized to the outer membrane surface of autophagosomes. Not detected in the Golgi of Garland cells.
Protein: CYB6_OENEH
Sequence: MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFASVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLAVLTASFGVTGYSLPWDQIGYWAVKIVTGVPDAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFLMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: FLIW_CAMJJ
Sequence: MTLAVKCPILGFEETKNMEFSTIDEVFVRLKSLDGKDFSFVLINPYLIRPDYEFDIPTYYQELLSLTPESNMKIFNIVAIAKSIEESTVNFLAPVVINLDNNTMVQVILDTVNYPDFFQADQIANYIKK
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHR2_ORYSI
Sequence: MERISTNQLYNSGIPVTVPSPLPAIPATLDENIPRIPDGQNVPRERELRSTPMPPHQNQSTVAPLHGHFQSSTGSVGPLRSSQAIRFSSVSSNEQYTNANPYNSQPPSSGSSSTLNYGSQYGGFEPSLTDFPRDAGPTWCPDPVDGLLGYTDDVPAGNNLTENSSIAAGDELAKQSEWWNDFMNYDWKDIDNTACTETQPQVGPAAQSSVAVHQSAAQQSVSSQSGEPSAVAIPSPSGASNTSNSKTRMRWTPELHERFVDAVNLLGGSEKATPKGVLKLMKADNLTIYHVKSHLQKYRTARYRPELSEGSSEKKAASKEDIPSIDLKGGNFDLTEALRLQLELQKRLHEQLEIQRSLQLRIEEQGKCLQMMLEQQCIPGTDKAVDASTSAEGTKPSSDLPESSAVKDVPENSQNGIAKQTESGDR
What is the function of this protein?
Transcription factor involved in phosphate starvation signaling (By similarity).  Binds to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes (By similarity).  Functionally redundant with PHR1 and PHR3 in regulating Pi starvation response and Pi homeostasis (By similarity).  Involved in both systematic and local Pi-signaling pathways (By similarity).  Regulates several Pi transporters (By similarity).  PHR2 binding to DNA is repressed redundantly by SPX1, SPX2 and SPX4 in a PI-dependent manner (By similarity).  The DNA-binding activity is also repressed by SPX4 (By similarity).  Involved in root growth under Pi deprivation (By similarity).  Involved in the modulation of Pi response and homeostasis together with RLI1; promotes RLI1 expression in response to nitrate availability, thus triggering the nitrate-induced phosphate response (NIPR) (By similarity).
What are the official names of this protein?
Protein PHOSPHATE STARVATION RESPONSE 2, OsPHR2.
What are the subcellular locations of this protein?
Nucleus.
Protein: GUAA_CROS5
Sequence: MTTQTPSLPNKPETLPTNTLDKSLDRQMIVILDFGSQYSELIARRIRETQVYSEVLSYRTTAQKLRQLNPKGIILSGGPNSVYDDRAPQCDPDIWQLGIPVLGVCYGMQLMVKQLGGQVEKALRGEYGKASLRIDDPTDLLTNVEDGSTMWMSHGDSCTRLPEGFSILAHTENTLCAAIADHDKKLFGVQFHPEVVHSVDGIALIRNFVYHICECEPTWTTEAFVDETIREIRAKVRDKRVLLALSGGVDSSTLAFLLHQAIGDNLTCMFIDQGFMRKGEPERLMDIFDKQFHIPVEYVNARDRFLKQLEGVTDPEKKRRLIGHEFIQVFEEESKRLGPFDYLAQGTLYPDVIESADTNIDPKTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRKVGRSIGLPEEIVRRHPFPGPGLAIRIIGEVTSERLNILRDADFVVRDEIGKQGMYHDFWQAFAVLLPIRSVGVMGDQRTYAHPIVLRLISSEDGMTADWSRVPYDLLETISNRIVNEVKGVNRVVYDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RSMG_HELHP
Sequence: MLPEVCYKHFTIFGDELLKWNKIHNLTGASSIESVMENIFDSLYPLRFIDDFTSCMDIGSGGGFPAIPLAIAKPQSHFILIEPRNKRSCFLQNIIIQLELNNVQVRPIRIQDVPIAEVNNLDLITSRALMDAKELISLSRKFLKSEGYFLLYKGTRFRQETPSMSIEECFTRENRIYYYKHSRDL
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_STAA3
Sequence: MKEKIVLAYSGGLDTSVAVQWLIDKGYDVVACCLDVGEGKDLDIVYKKALDMGAVECHIIDATKEFSDEYVSYAIKGNLMYENAYPLVSALSRPLIAKKLVEIAEKTNSVGIAHGCTGKGNDQVRFEVAIKALNPSLKAFAPVREWAWSREEEIDYAIKHNIPVSINHDSPYSIDQNLWGRANECGILEDPYAAPPEDAFDLTNALEETPDTADEIILTFDKGIPVQIDGKTYELDDLILTLNALAGKHGIGRIDHVENRLVGIKSREIYEAPAAEVILKAHKALETITLTKDVAHFKPIIEKQFAEQLYNGLWFSPLTDSLKLFIDSTQQYVSGDVRIKLFKGNAIVNGRKSPYTLYDEKLATYTKEDAFNQDAAVGFIDIYGLPTQVNAMLHGGYSNEQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3418_PSEF5
Sequence: MIVTTTAHIEGREIASYLDIVSAESVHGINVVRDLFAGMRDFFGGRSQTLERALKEARIQATNEIKERARQCNADAVVGVDFEISMPAGRGGMVVVFATGTAVRLK
What are the official names of this protein?
UPF0145 protein PFL_3418.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: ATGT_ARCFU
Sequence: MQRFEILDKDAMGRICRIETPHGRIETPTILPVINPNIPFIRAEEMKKFGAQAVITNSYIIYRSMREEALEKGVHGILETDMPVMTDSGSYQLMVYGDVEIKNAEIVEFQRHIGSDIIVPLDIPTPPDADYATAESDLRITLEREREAKELLKGAENLLAVPVQGSTHPDLRRFAAGEARKIGGDIYPIGAVVPLMDAYRFRDLARVILEVRSALPVEPIHLFGCGHPMLFAMAVALGCDLFDSAAYALYAKDDRYLTVYGTKKLSELNYFPCKCPVCSNHDPEELRRMEKNERERLIAEHNLYVSFQEIETIKQAIKENSLFELVEKRVRAHPNMLAGWRQVKHYWELLEKADPKMKRKFLYTGIDSLYRPAVRRHVKAIKNVELPEEVLVSTDFGIYANIYLRPVFGPVPAEMLETYPAGHAEIPEEDVVEEEALKAASEALMELMNSHPEKRFKVYVSKVWMKHLQNLPPNGELNVLS
What is the function of this protein?
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
What are the official names of this protein?
tRNA-guanine(15) transglycosylase, 7-cyano-7-deazaguanine tRNA-ribosyltransferase, Archaeal tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the archaeosine tRNA-ribosyltransferase family.
Protein: GCH4_THENN
Sequence: MKDVQNEKDTRMVPLKKVGIKDLSWPLKILLKGDGYQPTVAQISCSVDLHREKRGIHMSRFIEVLNGLEEITPHIFEKVLDDLIVTMEAKRAHLEIRFPYFVWKESPVTRKVSPLKVDCFVEAEKEKNFSFKIGVRVPVHNLCPCSKEISDYGAHNQRAFVEIHVRTRKFIWFEDLVEIAERNASVPLYTLLKRPDEKFVTERAYENPKFVEDVARDVALDLEKDPRITWYRVYVESMESIHNHNAFACVEKGDFVLEG
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RECA_RICCK
Sequence: MSNTDKERAIAAALAQIEKSYGKGSVMKLGQRPNIDIEAVSTGSLGLDMALGIGGVPKGRIIEIFGPESSGKTTLTLHLIAEAQKKGGTCAFIDAEHALDPAYAKKLGVNIDELIISQPDTGEQALEITDTLIRSGGIDMVIIDSVAALVPKSEIEGEMGDAQMASQARLMSQALRKLTASISRTNCIAVFINQIRMKIGVMFGSPETTTGGNALKFYASVRIDIRRIGSIKDKEEVIGSQTKVKVVKNKVSPPFKTADFDIMYGSGISKEGEIIDLGVKLDIVEKSGSWFSYNNVRIGQGRENVKQYLKEHPQIANEIEKIIREKSSKITNMNLDQMEEEND
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYSC_BOVIN
Sequence: MVLDLDLFRVDKGGDPALIRESQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGNDESIPEDVLNLDDLTADTLTNLKVSQIKKVRLLVDEAILKCDAERIKLEAERFESLREIGNLLHPSVPISDDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQFALRTLASRGYTPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYEEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMIATAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGILVPEKLKEFMPPGLQELIPFVKAAPIDQEPSKKQKKQHEGSKKKGAARDVALESQLQNMEVTDA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser).  Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).  In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC.  Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16).  Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
What are the official names of this protein?
Serine--tRNA ligase, cytoplasmic, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus.
Protein: ACT2_CRIJA
Sequence: MNRLIIVCLVAAMIYSTIALPMKEDISNDERPISVNEEPVKKNAAVAGAVIQGATLTFQVLDRILTVLGDISRKIAIGVDNESGRKWTAKNAYFFSGTSDVVLPYSVPNGKAFLYDGKKTRGPVATGAVGVLAYSMSDGNTLGILFSVPYDYNWYENWWNIKVYSGSKRANKWMYENLYYNASPHKGDNGWHEKSLGYGLKSRGYMASSGQTKLEIRVTRA
What is the function of this protein?
May be involved in digestion of prey (PubMed:29649486).  Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cytolysis.  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers (By similarity).  Shows hemolytic activity on equine erythrocytes (PubMed:29649486).  Hemolysis is highly inhibited in presence of sphingomyelin, suggesting that this protein targets sphingomyelin (PubMed:29649486).
What are the official names of this protein?
Deep sea actinoporin Cjtox II, DELTA-actitoxin-Cja1b, DELTA-AITX-Cja1b.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
Protein: RS18_BACAA
Sequence: MAGRKGGRAKRRKVCFFTSNGITRIDYKDVDLLKRFVSERGKILPRRVTGTSAKYQRKLTVAIKRARQMALLPYVGE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: ARREH_ACIF2
Sequence: MSGNLPNTDDVLLQVPDVRCLRSAAETDHPPRILLLYGSNRECSYSRLLTLEAERLLRYFGAETRVFHPTGLPLPDDAPVTHPKVVELQELVEWSEGQVWCSPERHGAMTGVFKSQVDWIPLNSGAIRPTQGKTLALMQVCGGSQSFNAVNQMRILGRWLRMLTIPNQSSVPKAFLEFDDGGRMKPSAYYDRVVDVMEELMKFTLLTRGNSDYLVDRYSERKESAEELSRRVNLQNL
What is the function of this protein?
Has NADPH-dependent FMN reductase activity and high NADPH-dependent ferric reductase activity with highest activity for Fe(3+) as substrate.  No activity with NADH, iron trichloride, Cu(2+) or Ag(+).  May be involved in cytosolic ferric iron assimilation as an NADPH-dependent ferric reductase in vivo.
What are the official names of this protein?
NADPH-dependent FMN reductase ArsH, Arsenical resistance operon protein ArsH.
What is the protein family that this protein belongs to?
Belongs to the ArsH family.
Protein: CYB_CAEFU
Sequence: MTNSRETHLLMKIINHSFIELPTPSNISAWWNFGSLLGACLMIQILTGLFLAMHYISDTMTAFSSVAHICRDVNYGWLIRNMHANGASMFFMCLYLHIGRGIYYGSYLYKETWNIGVVLLFAVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTSLVEWIWGGFSVDKATLTRFFAFHFILPFIILALVIVHLLFLHETGSNNPSGINPDSDKIPFHPYYTIKDILGLFMMAFTLVMLALFSPDMLGDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLIIPLLHTSTQRSLMFRPISQSLFWILTANLFILTWIGGQPVEQPYIIIGQTASILYFMIIILLMPLAGMIENHMLKPKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL15_BORPD
Sequence: MSDIQLNTLKPAEGAKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFTPLGQHLYAEVRLSDLQALPVDEIDVQTLKAAGVVGQAVRYAKVIKSGELSRKVTLKGLTATAGARAAIEAAGGSLA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: CYB_ACRDU
Sequence: MPHQQILMLFGLLPVATNISTWWNFGSMLLTCSALQIMTGFFLSMHYTANINLAFSSIVHVVRDVPHGWMMQNLHAIGASMFFICVYIHVARGLYYGSYLNKETWLSGTTLLIMLMATAFFGYVLPWGQMSFWAATVITNLLTAIPYLGTTMTTWLWGGFAINDPTLTRFFALHFILPFGIISLSSLHIMLLHAEGSSNPLGTNSDIDKIPFHPYHTYKDLFMISSMIMIMLLTISFIPDIFNDPENFSKANPLVTPQHIKPEWYFLFAYGILRSIPNKLGGALALAMSITILLTVPFTHTANTRSMTFRPFMQLMFWTLVTTFMIITWTATKPVEPPYTMISQVTSSLYFMFFMSNPIVGWLENKIMKTQL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.