PharMolix/UniProtQA huggingface dataset:
Protein: PDX1_MESAU
Sequence: MNGEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFAGALGTLEQGSPPDISPYEVPPLAEDPAVAHLHHHLPAQLGLAHPPSGPFPNGTEPGGLEEPSRGQLPFPWMKSTKAHAWKGQWAGGAYAVEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTASGGVGGDEPEQDSAVTSGEELLALPPPPPPGGAVPPGVPAAAREGRLPPGLSASPQPSSIAPRRPQEPR
What is the function of this protein?
Activates insulin and somatostatin gene transcription.  Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut.  As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.  Binds the DNA sequence 5'-CC[CT]TAATGGG-3' (By similarity).
What are the official names of this protein?
Pancreas/duodenum homeobox protein 1, Homeodomain protein PDX1, Insulin promoter factor 1, IPF-1.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: S26A6_HUMAN
Sequence: MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
What is the function of this protein?
Apical membrane chloride-bicarbonate exchanger.  Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.
What are the official names of this protein?
Solute carrier family 26 member 6, Anion exchange transporter, Pendrin-like protein 1, Pendrin-L1.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Protein: ATPF2_AFIC5
Sequence: MAESHATGTTTHTEVPHGKPEFPPFNKDTFASQLVSFAIAFALLYVIVSRFALPRVGGVIKTREGTIEKDLAEAQAFRDESDLALKAYETELAAARTRAQAIGSETRDTLAAQSDAERKAVELSLSAKLAEAEKTISDMRTKAMGNVKAIAADATSAIVQQLSGTAPDAQLIDRAVDASLKGGRDAA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria (By similarity).
What are the official names of this protein?
ATP synthase subunit b 2, ATP synthase F(0) sector subunit b 2, ATPase subunit I 2, F-type ATPase subunit b 2, F-ATPase subunit b 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PP363_ARATH
Sequence: MSTVNHHCLLNFPHIPPSIPPNHRPKLLSSLSLYRKPERLFALSASLSLSPATIHECSSSSSSSSSSFDKEETEDIESVIDGFFYLLRLSAQYHDVEVTKAVHASFLKLREEKTRLGNALISTYLKLGFPREAILVFVSLSSPTVVSYTALISGFSRLNLEIEALKVFFRMRKAGLVQPNEYTFVAILTACVRVSRFSLGIQIHGLIVKSGFLNSVFVSNSLMSLYDKDSGSSCDDVLKLFDEIPQRDVASWNTVVSSLVKEGKSHKAFDLFYEMNRVEGFGVDSFTLSTLLSSCTDSSVLLRGRELHGRAIRIGLMQELSVNNALIGFYSKFWDMKKVESLYEMMMAQDAVTFTEMITAYMSFGMVDSAVEIFANVTEKNTITYNALMAGFCRNGHGLKALKLFTDMLQRGVELTDFSLTSAVDACGLVSEKKVSEQIHGFCIKFGTAFNPCIQTALLDMCTRCERMADAEEMFDQWPSNLDSSKATTSIIGGYARNGLPDKAVSLFHRTLCEQKLFLDEVSLTLILAVCGTLGFREMGYQIHCYALKAGYFSDISLGNSLISMYAKCCDSDDAIKIFNTMREHDVISWNSLISCYILQRNGDEALALWSRMNEKEIKPDIITLTLVISAFRYTESNKLSSCRDLFLSMKTIYDIEPTTEHYTAFVRVLGHWGLLEEAEDTINSMPVQPEVSVLRALLDSCRIHSNTSVAKRVAKLILSTKPETPSEYILKSNIYSASGFWHRSEMIREEMRERGYRKHPAKSWIIHENKIHSFHARDTSHPQEKDIYRGLEILIMECLKVGYEPNTEYVLQEVDEFMKKSFLFHHSAKLAVTYGILSSNTRGKPVRVMKNVMLCGDCHEFFKYISVVVKREIVLRDSSGFHHFVNGKCSCRDLW
What is the function of this protein?
May play a role in embryogenesis.
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At5g03800, Protein EMBRYO DEFECTIVE 175.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
Protein: PSB28_RIPO1
Sequence: MAQIQFSRGVAEPVIPDVRLTRSRSGQSGTATFYFREPSIFNSESTDEVTGMYLVDEEGEITTTEVKGKFINGKATDIEAILIMRSPEEWDRFMRFMERYAKEQGLEFSQAGQS
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FUCO_ECO57
Sequence: MANRMILNETAWFGRGAVGALTDEVKRRGYQKALIVTDKTLVQCGVVAKVTDKMDAAGLAWAIYDGVVPNPTITVVKEGLGVFQNSGADYLIAIGGGSPQDTCKAIGIISNNPEFADVRSLEGLSPTNKPSVPILAIPTTAGTAAEVTINYVITDEEKRRKFVCVDPHDIPQVAFIDADMMDGMPPALKAATGVDALTHAIEGYITRGAWALTDALHIKAIEIIAGALRGSVAGDKDAGEEMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRYNADFTGEKYRDIARVMGVKVEGMSLEEARNAAVEAVFALNRDVGIPPHLRDVGVRKEDIPALAQAALDDVCTGGNPREATLEDIVELYHTAW
What are the official names of this protein?
Lactaldehyde reductase, Propanediol oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.
Protein: TRMD_ECOLC
Sequence: MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPE_TREPA
Sequence: MERSFTLAPSLLSADFSALDRALVYLEAHGAQWVHLDVMDGHFVPNLTFGAPVLRCLRSKTHLPFDVHLMVSRPADLIEDFVQAGADFLTFHIEAEVHAHRLIHAIRGRGVKVGISLVPSTPVAALSEVLPFVDLVLVMTVNPGFSGQQMIAHCLSKVSALVQMRTERGYSYMISVDGGIDCRTLPQALDAGADVIVSGSAFFSGTLRSLLCKDSSGA
What is the function of this protein?
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
What are the official names of this protein?
Ribulose-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the ribulose-phosphate 3-epimerase family.
Protein: ORN_HUMAN
Sequence: MLGGSLGSRLLRGVGGSHGRFGARGVREGGAAMAAGESMAQRMVWVDLEMTGLDIEKDQIIEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTITLQQAEYEFLSFVRQQTPPGLCPLAGNSVHEDKKFLDKYMPQFMKHLHYRIIDVSTVKELCRRWYPEEYEFAPKKAASHRALDDISESIKELQFYRNNIFKKKIDEKKRKIIENGENEKTVS
What is the function of this protein?
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.
What are the official names of this protein?
Oligoribonuclease, mitochondrial, RNA exonuclease 2 homolog, Small fragment nuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion. Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
Protein: PSD_AFIC5
Sequence: MSIAHSIRAQIPPIHPEGYPFIGGFAFASLILFWLWAPLGWIGVVLTIWCALFFRDPVRTTPVREGLVIAPADGRVSMVTPVVPPAELGLGDQPLMRISIFMSVFNCHVNRSPVAGRIERIAYRPGKFINAELDKASEDNERNSLVISTPAGRIGVVQIAGLVARRIVSFVREGESLAAGQRFGLIRFGSRLDVFLPEGGKPLVSVGQTAVAGETVLADFQIGDGGRVYRTD
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RAB5C_MOUSE
Sequence: MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNAAGAPGRTRGVDLQESNPASRSQCCSN
What is the function of this protein?
Protein transport.  Probably involved in vesicular traffic.
What are the official names of this protein?
Ras-related protein Rab-5C.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome.
Protein: UREG_THEVB
Sequence: METVLRVGVAGPVGSGKTALVDALCKALRDRYRLAVVTNDIYTQEDAQFLVRSQALPPERILGVETGGCPHTAIREDASLNLAAIQQLETAFRPLDLIFVESGGDNLAATFSPELVDLTIYVIDVAAGDKIPRKGGPGITKSDLLVINKIDLAPYVGADLEVMKRDTLKMRGDRPYVMTNLKTGLGLDQVIAFLTVHLAA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JAK3_HUMAN
Sequence: MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
What is the function of this protein?
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation.  Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development.  In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R.  Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins.  Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor.  Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription.  For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain.  Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3.  Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
What are the official names of this protein?
Tyrosine-protein kinase JAK3, Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Protein: AR13A_MOUSE
Sequence: MFRLLTACWSRQKTTEEKQRNVTIIVIGLDNSGKSRLIEAFQRLIPSKMHKEMRPTQTTLLLDDYQVSIYDLTGDVKGREKWSSYYAQAHGLIFVVDSSDIARIQEVKIILTRIMFDKRVSGKPILILANKQDKKNALLPCDIIEYLLLERLVNETRSMCRVEPCSTIKRIPKRQQKPIVVGLRWLLAAIGDQYSELYTRQQIPNMSISTSKNIRGCGERCLSDSLPNRVRHSNRQHFDKRQHMEHRQHVEQRHFEKRQHFEARQRLIQRSLDARPLKPILQKDGFRIRPKKNMSVTFALDVIMEEGECSRKIGAPTISKPCSSQCYDTKTPDPSVDVSLFKAHKPKKRIETWDTEEMFLEDPREETFHSCD
What are the official names of this protein?
ADP-ribosylation factor-like protein 13A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily.
Protein: TRI63_HUMAN
Sequence: MDYKSSLIQDGNPMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCANDIFQAANPYWTSRGSSVSMSGGRFRCPTCRHEVIMDRHGVYGLQRNLLVENIIDIYKQECSSRPLQKGSHPMCKEHEDEKINIYCLTCEVPTCSMCKVFGIHKACEVAPLQSVFQGQKTELNNCISMLVAGNDRVQTIITQLEDSRRVTKENSHQVKEELSQKFDTLYAILDEKKSELLQRITQEQEKKLSFIEALIQQYQEQLDKSTKLVETAIQSLDEPGGATFLLTAKQLIKSIVEASKGCQLGKTEQGFENMDFFTLDLEHIADALRAIDFGTDEEEEEFIEEEDQEEEESTEGKEEGHQ
What is the function of this protein?
E3 ubiquitin ligase.  Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH.  Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids.  Inhibits de novo skeletal muscle protein synthesis under amino acid starvation.  Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins.  May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway.  May regulate the organization of myofibrils through TTN in muscle cells.
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM63, Iris RING finger protein, Muscle-specific RING finger protein 1, MuRF-1, MuRF1, RING finger protein 28, RING-type E3 ubiquitin transferase TRIM63, Striated muscle RING zinc finger protein, Tripartite motif-containing protein 63.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle.
Protein: RNFA_MARN8
Sequence: MTEYLLILVSTILVNNFVLVQFLGLCPFMGVSGKLETAMGMSLATTFVLTLSSVCSYLAYTYLLAPLDLAFLKTITFILVIAVVVQFTEMVVRKTSPLLYRVLGIFLPLITTNCAVLGVALLNLNKNNNFVESVLYGFGAAAGFSLVLVLFAAMRERIAVSDVPVAFRGAAIGMITAGLMSLAFLGFTGLVAV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NTPPB_BURPS
Sequence: MQHHACSPPRLILASSSRYRRELLERLRVPFDVVAPEIDETPLPDETPCATALRLAAAKARAAAERARAPHGALVIGSDQVATFDGLQIGKPGTHARALAQLQAMRGRDVEFHSALCLYDSRSGATQSEDIVTRVRFRTLTDVELDAYLRAETPYDVAGSAKSEGLGIALLDAIDSDDPTALVGLPLIALTRMLRAAGYPLFGAPAPAADGVNGR
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K1C39_MOUSE
Sequence: MDTKGSTVTISSSTPPQNCSGNTNFRTNSSSNKSCCHDGQSTGCALQTPQGQGCGSSPCLYRCPHYLIRTYSFHPCLDDGSRCTEGINTHEKETMQILNERLANYLEKVRMLEGENADLEDKIQEACSKALPILCPDYLSYYTTIEELQQKILCTKAENSRLVSQIDNTKLAADDLRANYEAELSLRQLVEADANGLKQILDALTLSKADLEARVQSLTEELLCLKTNHEEEVNSLQCQLGDRINIEVTAAPSVDLNQILQEMRCRYESIMETNRKDVEEWFNTQMEELNQQVVSSSQQQQCCQKDIIELRRTISALEIELQAQHRMRESQECILTETEARYTALLAQIQSLIHNLEAQVADIRSALQRQSQEYEVLLDIKSRLECEIATYRSLLESLDGRLPCNPCATKWEPSCQARAMECFTPVYTSSSLPGIHKPCRASGPPSRILVKICTITKEIKDGKVISSYEHVQPCYITRATKV
What is the function of this protein?
May play a role in late hair differentiation.
What are the official names of this protein?
Keratin, type I cytoskeletal 39, Cytokeratin-39, CK-39, Keratin-39, K39, Type I hair keratin Ka35.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: RPOZ_GEOSW
Sequence: MLYPSIDLLMQKVDSKYKLVTVAAKRARQLQENEELTIKNPVSKKFVGQALEEIAADHIELVEEK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RL30_BRASB
Sequence: MADAKTIKIEQIGSPIRRHHSQRETLIGLKLNKIGRVTELPDTPAVRGMITKVHHLVRIVDEK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: VM2_BOTCO
Sequence: EAGEECDCGAPENPCCDAATCKLRPGAQCAEGLCCDQCRFKGAGKICRRARGDNPDDRCTGQSADCPRNRFH
What is the function of this protein?
Inhibits fibrinogen interaction with platelets.  Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.
What are the official names of this protein?
Disintegrin cotiarin, Platelet aggregation activation inhibitor.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL16_BIFLD
Sequence: MLIPKRTKYRKQHRPVRSGMSKGGNEINFGDFAIQSLAPAYVTNRQIEAARIAMTRYIKRGGRVWITIFPDRPLTKHPLGARMGSGKGAPEFWIANVRPGRVMFEIGGVSEDIAKEALRRAIDKLPMKCRIIAREGGDI
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: MNMA_CORDI
Sequence: MRVLAAMSGGVDSAVAAARAVAAGHDVVGVHLALSQDPQTVRESSRGCCSLEDSADARRVCDKLGIPFYVWDFSDRFKEDVIDDFISSYEAGETPNPCLRCNEKIKFAALLERGIALGFDAVVTGHYARLTQPVDGGDGYLRRSIDPDKDQSYVLGVLGAHEIAHCMFPVGDTVKPKIREEAAAMGFSVAKKPDSYDICFIPDGNTQAFLGRHIGLRPGMIVDSDGNELKEHDGAWNYTIGQRKGLDIKQPAADGKPRYVTNIDAATGTVTVGSRENLKVIALTADRLKYLHPAMTGSFEAEVQVRAHGSVVACSVMVNESDDTMRVELHTPLSGVARGQAAVIYLPDDDGDIVLGSGTICATEHQ
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_DESDA
Sequence: MEYSAEDISPVRKKVVITTEPQEVEASIMGTIALYKTSVQVDGFRKGKVPASVIEQRFRDKIYEEARQDLINVHINDVMQKLDVMPLAGLDVDTPDAFERGKGFAYTIEFEVLPTFDLPPYEGMDVEQEKVVVDEKEVQEVLDRILRDRAQLVPVEGKGPAVDGQIATVDFAAFENGEPVEGVKAESFDLALGERQALEDFEALVKTIPYGEEGEGEIHFPEDFIAKDLAGKTVTMKVKVHAIKERKLPALDDELAKSLGLESVEKLKEAITKSYTESRTGLNRSAAQKSLLDGLLKMVAFELPPSLVETQMNTLLADMAGRLERQGRSLESLGKSMEDLRKDMQPQADELARAQVLLLSVAKKEGLDVTDHEVTTQIYQLAMRTGEDFKALREQYERSGMIFVLRDRMLADKAMDLIYAKANVKEVEPKAPETGAEADAAPGASASAQESK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: CSM5_STRTR
Sequence: MKNDYRTFKLSLLTLAPIHIGNGEKYTSREFIYENKKFYFPDMGKFYNKMVEKRLAEKFEAFLIQTRPNARNNRLISFLNDNRIAERSFGGYSISETGLESDRNPNSAGAINEVNKFIRDAFGNPYIPGSSLKGAIRTILMNTTPKWNNENAVNDFGRFPKENKNLIPWGPKKGKEYDDLFNAIRVSDSKPFDNKRLILVQKWDYSAKTNKAKPLPLYRESISPLTKIEFEITTTTDEAGRLIEELGKRAQAFYKDYKAFFLSEFPDDKIQANLQYPIYLGAGSGAWTKTLFKQADGILQRRYSRMKTKMVKKGVLKLTKAPLKIVKIPSGNHSLIKNHESFYEMGKANFMIKEIDK
What is the function of this protein?
This subunit might be involved in maturation of a crRNA intermediate to its mature form.
What are the official names of this protein?
CRISPR system Cms protein Csm5, CRISPR type III A-associated protein Csm5.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csm5 family.
Protein: FOLD_MYCLE
Sequence: MGAITLDGKATRDEILIDLKQRVAALTESGRTPGLGTILVGDDPGSHAYVRGKHADCAKVGITSIRRDLPVDITTAVLHDTIEELNANPDCTGYIVQLPLPKYLDENTALERVDPAKDADGLHPTNLGRLVLSTPAPLPCTARGILHLLRRYGVEIAGTHVVIIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRNLAALTKQADIIVAAVGVPHLLTADMVRPGAVVVDVGVSRVETRLVGDVHPDVWEVAGHVSPNPGGVGPLTRVFLLTNVVELAEGRQ
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RTF1_SCHPO
Sequence: MADFQDELLALAGIDDSDVASNRKRAHDDLDDVLSSSSDEDNNENVGQDYAEESGGEGNEKSEDEFEEKFKNPYRLEGKFKDEADRAKIMAMTEIERESILFEREEEISKLMERRELAIRLHQQNAQYMAQSTRRSTRDKPLTSAAAGKRDKLTELKKRRQERSARSVSERTRKRSPVSDYEEQNESEKSEEEEGYSPSYAEEKVEQVSKDNASANLYDLNAIRLGRKHVAEYMYHPIFESTVTGCFVRVKIGERDGQGVYRLCQVKGILESRKPYRVDGVLTKVSLECFHGRSKRVFDVNVLSNEPFSDHDFQRWHHQMMEDKLSMPSKNFVQRKLNDLRDMSKYVLSEKEVSDIINRKKELSRVPSNIAAEKTRLRQRRQAAYVAGNAELVKEIDDQLNTLEELSMGSNQNSNSAMDQLAKVNERNRRRNHTEIRLAEQRMNEERRRLSAAATATPMSAPTSVLTGTSPQPSPSLSTSIMSTPKLNPSESVVVASEKASSPDLSPKLLPSESQIFDEGIAVTQTPNTLEDKDFKLHEKAVHGIDDIIATVDFGIDINI
What is the function of this protein?
The PAF1 complex is a multifunctional complex.  Involved in transcription initiation via genetic interactions with TATA-binding proteins.  Involved in elongation.  Also has a role in transcription-coupled histone modification.  Important for TATA site selection by TBP.  Directly or indirectly regulates the DNA-binding properties of the TATA box-binding protein, and the relative activities of different TATA elements (By similarity).
What are the official names of this protein?
RNA polymerase-associated protein C651.09c, Protein RTF1 homolog.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.