PharMolix/UniProtQA huggingface dataset:
Protein: DXR_BURVG
Sequence: MQKRLTLLGSTGSIGDSTLDVVARHPERFSVYALTAHRNGDKLVEQCLRFAPEVAVVGDAATAAHVEAKLRAAGSKTTVLYGPQALVDVSASDGCDTVVAAIVGAAGLAPSLAAARAGKRILLANKESLVMSGGIFMDAVRDHGAILLPVDSEHNAIFQCMPRDENEHGGISKIILTASGGPFRTREPATLADVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWIFGLPGERIDVLIHPQSVIHSLVSYRDGSVLAQLGNPDMRTPIAHALAFPERVDAGVDQLDLAQIAQLSFEKPDYARFPCLALALKALEEGGIASAALNAANEVAVEAFLERRIGFMAIAATVDAVLNALPNRSPNGLDDVLAADADARRLAAGFIAKAPAPRVERIV
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: SYE2_METRJ
Sequence: MTLVRFAPSPTGYLHIGNARPALLNALFARRTGGRFLLRLDDTDAERSTEAFAEAIGEDLAWLGIVPDLFARQSARTAQHDAAADRLRAAGRLYPCYETPEELERRRRRQLGRGQPPIYDRAALRLTGDERAALEAEGRRPHWRFLLEARTVGWDDLVRGPAHVDCASLSDPVLIRADGSYLYTLPSVVDDADLGITHVIRGEDHVTNTGVQVQIFEALGAAVPVFGHHNLLTTADGEGLSKRLGHLSLRGLREAGYEPAAVRSLAVLTGSAESVRAVPDLDTLAGLVDLGEISRAPARFDPAELDGLNARLIHAMPYREAAARLADLGIPADRAEAFWLAVRANLSRVPEAAPWWRVVTGPVEPVLTEPAVIAAAVESLPPEPFGPETWNAWTTEIRTRTGAKGRGLFMPLRLALTGLEHGPDLAGLLPLIGRERAARRLSGAAA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIND_LYTVA
Sequence: MARQLSVILVALTLTTALAENFPTRTSAPSDCPQADQGCWCHKNFAQCWSTYDDSRLTEEIGSRITRLELLYQPNEEVVTYIRRMSALREIRISEDGMSLDCSCDLVDAMDDKGITLVNQDELEIRNCRQQGWSRDTMTARPFLIECRRFRIQDDDRRKRRDAEQDSDDVTKRASPRKGDKPAGHKLKDLAPKDTHHLVSIDDVEKHPATDFFNFISGHRRTRRSTGTNEEVSDDSGRSARKKRYGNMNYPQPMNQPMGGGNYPGQPPQQNYAPQGMGGPVGGGGMGGAVGAGAMGGPVGGGGGGMGGPVGGANGIGESVEDEMSVDSDYSSLGGETTISAKVIQDIKNLLGATKIDLPVDINDPYYLGLLLRHLRHHSNLLANIGDPEVREQVLSAMQEEEEEEENDAANGVRENVLNNLNAPGQGGYGGTQGGMRGGAGGGMMGNQGMGGQGYNQGYMQG
What is the function of this protein?
Species-specific sea urchin sperm protein required for adhesion of sperm to the egg surface during fertilization.  Bindin coats the acrosomal process after it is externalized by the acrosome reaction.  It binds to sulfated, fucose-containing polysaccharides on the vitelline layer receptor proteoglycans which cover the egg plasma membrane.
What are the official names of this protein?
Bindin.
What is the protein family that this protein belongs to?
Belongs to the bindin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome lumen.
Protein: BIRC7_MOUSE
Sequence: MFSPADLFRAAVFSMGPESRARDSVRGPELSHREDGSGRTQEQDKPHCPCNHVLGQDCLDGQILGQLRPLSEEEESSGAAFLGEPAFPEMDSEDLRLASFYDWPSTAGIQPEPLAAAGFFHTGQQDKVRCFFCYGGLQSWERGDDPWTEHARWFPRCQFLLRSKGRDFVERIQTYTPLLGSWDQREEPEDAVSATPSAPAHGSPELLRSRRETQPEDVSEPGAKDVQEQLRQLQEERRCKVCLDRAVSIVFVPCGHFVCTECAPNLQLCPICRVPICSCVRTFLS
What is the function of this protein?
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control.  Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity.  As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival.  May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions.  Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine.  Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2.  This activation depends on TAB1 and MAP3K7/TAK1.  In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9.
What are the official names of this protein?
Baculoviral IAP repeat-containing protein 7, Livin, RING-type E3 ubiquitin transferase BIRC7.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
Protein: HBA_CHLME
Sequence: VLSAADKANVKGVFSKIGGHADDYGAETLERMFIAYPQTKTYFPHFDLHHGSAQIKAHGKKVAAALVEAVNHIDDITGALSKLSDLHAQKLRVDPVNFKFLGHCFLVVVAIHHPAALTPEVHASLDKFMCAVGAVLTAKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-A, Alpha-A-globin, Hemoglobin alpha-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: NRAM_I06A0
Sequence: MNPNQKIITIGSISIAIGIISLMLQIGNIISIWASHSIQTGSQNHTGICNQRIITYENSTWVNHTYVNINNTNVVAGKDKTSVTLAGNSSLCSISGWAIYTKDNSIRIGSKGDVFVIREPFISCSHLECKTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPLGEAPSPYNSKFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITGTIKSWKKQILRTQESECVCMNGSCFTIMTDGPSNGAASYKIFKIEKGKVTKSIELNAPNFHYEECSCYPDTGTVMCVCRDNWHGSNRPWVSFNQNLDYQIGYICSGVFGDNPRPKDREGSCNPVTIDGADGVKGFSYKYGNGVWIGRTKSNRLRKGFEMIWDPNGWTNTDSDFSVKQDVVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELVRGLPRENTTIWTSGSSISFCGVNSDTANWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: F107B_BOVIN
Sequence: MAEPDYIDDDNPELIRPQKLVNPVKTSRNHQDLHRELLMNQKRGLAPQNKPELQKVMEKRKRDQVIKQKEEEAQKKKSDLEIELLKRQQKLEQLELEKQKLQEEQENPPEFVKVKGNLRRTGQEVAQTQES
What are the official names of this protein?
Protein FAM107B.
What is the protein family that this protein belongs to?
Belongs to the FAM107 family.
Protein: HMCES_XENTR
Sequence: MCGRTACTLAPDDVRKACTYRDKQGGRKWPNWRDGDSDKYQPSYNKSPQSNSPVLLSLKHFQKDADSSERVLAAMRWGLIPSWFNEPDPSKMQYKTNNCRSDTMTEKALYKASLFKGKRCVVLADGFYEWQRQNSEKQPYYIYFPQIKAEKSPAEQDITDWNGQRLLTMAGLFDCWEPPNGGETLYSYTVITVDSSKTMNWIHDRMPAILDGDEAVRKWLDFGEVPTKDALKLIHPIENITYHPVSTVVNNSRNNTPECMAAIILTQKKGPALSASSKKMLDWLQNKSPKKEESHSIQSPKLSQFGAPPKKTSAGLMQQWLKKEDGEPSPKRAKK
What is the function of this protein?
Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites.  Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue.  The HMCES DNA-protein cross-link is then degraded by the proteasome.  Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks.  Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity).  Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).
What are the official names of this protein?
Abasic site processing protein HMCES, Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, Peptidase HMCES, SRAP domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SOS response-associated peptidase family.
What are the subcellular locations of this protein?
Chromosome. Note=Recruited to chromatin following DNA damage. Localizes to replication forks.
Protein: TDH_PIG
Sequence: MPVVKMLKQVASRTLGSPACGCQPPTLPRRFLGTSPRQIPADANFHSTSFSEANQPRVLITGGLGQLGVGLASLLRKRFGKDNVILSDIRKPPEHVFLSGPFIYSDILDYKNLREIVVNNRVTWLFHYSALLSAVGEANVSLARAVNITGLHNVLDVAAEHGLRLFVPSTIGAFGPTSPRNPTPDLCIQRPRTIYGVSKVHAELMGEYYYYRYGLDFRCLRYPGIISADSQPGGGTTDYAVQIFQDAVKNGRFECNLNPGTKLPMMYIDDCLRATLEVMEAPAEALSLRTYNVNAMSFTPAELAQEVLKHIPEFQITYNVDSVRQAIADSWPMNFDDSTARRDWGWKHDFDLPELVTTMLNFHGAHSRVAQAN
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.
What are the official names of this protein?
L-threonine 3-dehydrogenase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: RL10_THEP3
Sequence: MGTAKEKKQQIVAEFKDKLSQAQTVIFSNFSGLTVEDDTILRRKFREANSEYKVYKNTLMTIAAKELGYGDDLIKYFEGPTSVAFGYDDPVAPAKVLVEFMKDHKGIELKAGLVNGKLVTVEEIKALAELPSREELVAKALGSMKAPITNLVFVLSGTLRSLLYALNAVKEKKQAEA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: VTC2_YEAST
Sequence: MLFGVKLANEVYPPWKGSYINYEGLKKFLKEDSVKDGSNDKKARWDDSDESKFVEELDKELEKVYGFQLKKYNNLMERLSHLEKQTDTEAAIKALDADAFQRVLEELLSESTELDNFKRLNFTGFAKIVKKHDKLYPKYPSVKSLLEVRLKELPSHSEEYSPLLYRISFLYNILRSNFNTASEPLASASKFSSIVSNDIDMNFRSFKFWVHNDNLMEVKTRILRHLPVLVYANVPSENDDLVNRFESDISNNDEIVGSSSSTSSVEHGLGARSFDPLINTLYFDNEHFELYNDKLLKLNSAPTLRLRWTGQLSDKPDIFLEKKTLIEDEATGKSEFDLTKLQLKQKFINGFIFEGDKKFKEQTLKKLKESGTAGRDLERLEEDFSEIQNFIIKNELQPVFRTVYTRTAFQIPGDDKIRVTIDSNIVFIKEDSFDRERPIRDPNTWHRTDIDANVANPLKFLRGGEYAKFPYSVMEIKVKSSLDSSMSASSMISNVKLPKKHGQWLNDLTNSHLVKEIPKFSIFVQGVASLYGDDEKLDILPFWLPDLETDIRQDPKQAYEEEKKKLLKQKEIQKKIDGMRRLSNLKEPQHQAAVPVSQEENERITSQGDLEADGSSDEETEQEPHSKRSKKVRRRKPKATFLRILAGRDPKLMGVDSEEEEIELPPGVKKPLNLLKNAGPVNVEAKVWLANERTFNRWLSVTSLLSVLTFSIYNSVKKAEYPTLANYMAYVYFGLTIFCALWSYSIYMKRVDIIQQRSGQHLDAPLGPVLVSIVLFVTLVVNFVMAFRNAAKSRQELQIQNLEVPERIPEVLRPLQNYLFKLMGPSSD
What is the function of this protein?
Accessory subunit of the vacuolar transporter chaperone (VTC) complex.  The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP.  VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046).  The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046).  PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834).  Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106).  Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).  The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419).  Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419).
What are the official names of this protein?
Vacuolar transporter chaperone complex subunit 2, Phosphate metabolism protein 1, SPX-dependent polyphosphate polymerase VTC subunit 2, Vacuolar membrane polyphosphate polymerase accessory subunit 2, PolyP polymerase.
What is the protein family that this protein belongs to?
Belongs to the VTC2/3 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: VE6_HPV36
Sequence: MAEQASEQQNITEKEKEQLPLTIKGLSESLGIPFVDCLIPCNFCGKFLDYLEACEFEVKKLSLIWKDYCVFACCRVCCGATATYEFNQFYQQTVLGRDIELAAGRSIFEIDIRCQTCLAFLDIIEKLDCCGRGLPFHRVRNAWKGICRQCKHFYNDW
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: POK11_HUMAN
Sequence: NKSRKRRNRVSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLIIIDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRALQPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHYLGMQIENRKIKPQKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRILTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAWQIGLANFVGIIDNHYPKTKIFQFLKMTTWILPKITRREPLENALTVFTDGSSNGKAAYTGPKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYVVQATRDVETALIKYSMDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEEADLLVSSALIKAQELHALTHVNAAGLKNKFDVTWKQAKDIVQHCTQCQVLHLPTQEAGVNPRGLCPNALWQMDVTHVPSFGRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAFQKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALYTLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSPGENQLPVWIPTRHLKFYNEPIGDAKKRASTEMVTPVTWMDNPIEVYVNDSVWVPGPTDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPTVQNWLVEVPIVSPICRFTYHMVSGMSLRPRVNYL
What is the function of this protein?
Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA.  The RNase H domain of the reverse transcriptase performs two functions.  It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid.  Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome.  Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity).
What are the official names of this protein?
Endogenous retrovirus group K member 11 Pol protein, HERV-K_3q27.2 provirus ancestral Pol protein.
What is the protein family that this protein belongs to?
Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.
Protein: HSP71_SOLLC
Sequence: MAGKGEGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVGFTDTERLIGDAAKNQVALNPINTVFDAKRLIGRRFSDASVQEDMKLWPFKVIPGPGDKPMIVVTYKGEEKEFAAEEISSMVLTKMKEIAEAFLGSTVKNAVVTVPAYFNDSQRQATKDAGVISGLNVMRIINEPTAAAIAYGLDKKATSAGEKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVHEFKRKHKKDITGNPRALRRLRTACERAKRTLSSTAQTTIEIDSLYEGVDFYSTITRARFEELNMDLFRKCMEPVEKCLRDAKMDKSTVHDVVLVGGSTRIPKVQQVAMTNFFNGKELCKSINPDEAVAYGAAVQAAILSGEGNEKVQDLLLLDVTPLSLGLETAGGVMTVLIPRNTTIPTKKEQVFSTYSDNQPGVLIQVFEGERRARTRDNNLLGKFELSVIPPAPRVVPQITVCFDIDANGILNVSAEDKTTGQKNKITITNDKGRLSKEEIEKMVQEAEKYKAEDEELKKKVEAKNSLENYAYNMRNTVKDEKIGSKLSSDDKKKIEDAVDQAISWLESNQLAEVDEFEDKMKELEGICNPIIAKMYQGAGGDAGVPMDDDAPPSGGSSAGPKIEEVD
What are the official names of this protein?
Heat shock cognate 70 kDa protein 1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: IHH_PUNTE
Sequence: VMNLWPGVRLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYAMLARLAVEAGF
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.
What are the official names of this protein?
Indian hedgehog protein, IHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Cell membrane. Secreted, extracellular space. Note=Indian hedgehog protein N- product: Cell membrane; Lipid-anchor; Extracellular side. The N- terminal peptide remains associated with the cell surface. Indian hedgehog protein C-product: Secreted, extracellular space. The C- terminal peptide diffuses from the cell.
Protein: SELU_PSEA8
Sequence: MRDNTQHYRELFLDDIPLMDVRAPVEYHKGAFPNTVNRPLMNDIERQKVGTSYKQHGQQAAIALGHELVCGALKAERLAAWKAFAEANPNGYLYCFRGGLRSQIVQQWLKQDAGIDYPRVIGGYKALRNFLFETTRAAVDECDFVLVGGLTGCGKTEVIAALDNSLDLEGHANHRGSSFGRRATPQPAQIDFENRLAIDILKKRHRGVGQFVLEDEGRIVGSCSLPLELYQGMQSYPLVWLEDAFEQRVERILRDYVIDLRSEFERVVGVEEGFAAFSAYLQKSLAGIVKRLGGERYQRLAAILVQALEEQGRDGSVDTHRGWIEGLLKEYYDPMYAFQRQSKEDRVEFRGNQAEVIGYLRQRQALRPS
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: ACKA_BACCR
Sequence: MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGLEDSIFTITVDGEKQKEITNIPDHAVAVNMLLKKLTENGIVKSLDEIGGIGHRVVHGGEKFADSVLITDEVLADIEELSDLAPLHNPANVVGIKAFQEVLPNVPAVAVFDTAFHQTMPESAFLYSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPIESLSLLSCHLGNGASIAAVEGGKSIDTSMGFTPLAGVTMGTRSGNLDPALIPYIMEKTGQTVEEVVNVLNKKSGMLGLTGYSSDLRDIIAKEEEGDHRAKVALDVFVSRIHKYIGSYTARMKGVDAIIFTAGVGENSAIIRERVLEGLEYMGVYFDAKRNNVFGEEAFISFPHSPVKIIVIPTDEEVMIARDVLRLGDIG
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_STRPJ
Sequence: MSDKIGLFTGSFDPMTNGHLDMIERASRLFDKLYVGIFFNPHKQGFLPLENRKRGLEKAVKHLGNVKVVSSHDELVVDVAKRLGATCLVRGLRNASDLQYEASFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACYVPESILEEIRNEKKD
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBSB_SYNP6
Sequence: MEKTIGLEIIEVVEQAAIASARLMGKGEKNEADRVAVEAMRVRMNQVEMLGRIVIGEGERDEAPMLYIGEEVGIYRDADKRAGVPAGKLVEIDIAVDPCEGTNLCAYGQPGSMAVLAISEKGGLFAAPDFYMKKLAAPPAAKGKVDINKSATENLKILSECLDRAIDELVVVVMDRPRHKELIQEIRQAGARVRLISDGDVSAAISCGFAGTNTHALMGIGAAPEGVISAAAMRCLGGHFQGQLIYDPEVVKTGLIGESRESNIARLQEMGITDPDRVYDANELASGQEVLFAACGITPGLLMEGVRFFKGGARTQSLVISSQSRTARFVDTVHMFDDVKTVSLR
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6-phosphate and sedoheptulose 7-phosphate, respectively.
What are the official names of this protein?
D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase, FBPase class 2/SBPase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 2 family.
Protein: CYCH_BRADU
Sequence: MTLWFVFALMTVAAIFAVLWPLGRSARAQNQGSEVVVYKDQLTEIERDLASGLIAAPEAEAARVEISRRLLAAAGSEPVSEPKSSLKWRRAAAVLALVGLPLVAIGVYMPLGSPRLQDFPLAQRERGSGSGMAGSLENLVVQVEQHLEKNPTDGRGWNVLAPVLERLGRFDDAVRAYRNSITYNGESPERRSDLGEAISAAAGGVVTAEAKTEFERAHALNADDPKANYFLGLAAEQDGRKDDAATIWRALLAKAPADAPWRPLVQSSLVRVGGGTMPALSDETIAASKDMSEGDRGAMVRGMVERLATRLKQNSDDVEGWLRLVRAYLVMGDRDKAVGASSDARQAVAKDTERLRQLNEGLKTLGLDG
What is the function of this protein?
Required for the biogenesis of c-type cytochromes.  Possible subunit of a heme lyase.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CycH.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Periplasmic side.
Protein: METN2_PSEAE
Sequence: MIEFHDVHKTYRVAGREIPALQPTRLNIQAGQIFGLIGHSGAGKSTLLRLINRLEEPSGGRILVEGEDVTALDAEGLRRFRQRVGMIFQHFNLLSSKTVADNIAMPLRLAGGFSRAEVDARVSELLARVGLSDHARKYPAQLSGGQKQRVGIARALACRPSILLCDEATSALDPQTTASVLQLLAEINRELKLTIVLITHEMDVIRRVCDQVAVMDGGAIVEQGDVADVFLHPQHPTTRRFVFEAERVDEDERHDDFAHVPGLILRLTFRGEATYAPLLGTVARQTGVDYSILSGRIDRIKDTPYGQLTLALVGGDLEAAMSQLNAADVHVEVLR
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RK33_IPOPU
Sequence: MAKSKDVRVAVILECTSCVRNGVNKVSTGISRYITQKNRHNTPNPLELKKFCPYCYKHTIHGEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y010_HIS1I
Sequence: MMYPKNLPAGADTLIGMVGAISLTVMMILFFIAIVWFLQGTR
What are the official names of this protein?
Uncharacterized protein ORF10.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.