PharMolix/UniProtQA huggingface dataset:
Protein: GLYA_HAEIG
Sequence: MFTRNMTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAIDRAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITADGLIDYEDVRQKALECKPKLIVAGFSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPHAHVVTTTTHKTLGGPRGGLILSSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPQYKEYQANVIKNAKAMVEVFKQRGYDVVSNGTENHLFLVSFIKQGLTGKAADAALGKANITVNKNAVPNDPQKPFVTSGIRVGTPSVTRRGFNENDVRELAGWMCDVLDALGKENEEQVIAETKEKVLAICKRLPVYPK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_LACGA
Sequence: MGKGEIVQVIGPVVDVEFPLDKDLPDINNALRVTNNNGDTLVLEVTLELGDGVLRTISMESTDGLRRGMEVEDTGAPISVPVGKDTLGRVFNVLGDPIDGGPALGKDVKREGIHKEAPKYDELSTSEEILETGIKVIDLLEPYVRGGKVGLFGGAGVGKTTIIQELIHNIAQEHGGISVFTGVGERTREGNDLYFEMKASGVLSKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGLDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTKKGSITSIQAVYVPADDYTDPAPATTFAHLDATTNLERRLVEQGIYPAVDPLESTSSALDPEVVGEEHYQVAVQVQHILQRYQELQDIISVLGMDELSDDEKLIVERARKIQFFLSQNFFVAEQFTGLPGSYVPIKETIKGFKMIIDGKLDDLPEDAFRNVGPIEDVVKKAEKMGVTPKNPEAKAMLEAK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NU3C_CHLSC
Sequence: MFLLHEYDIFWAFLIISSVIPILVFLISGVLAPINEGPEKLSSYESGIEPMGNAWLQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSVFIEALIFVLIPIVGSVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RS4_LACE2
Sequence: MAVNRTPVLKRCRSLEMDPVYLGIDKKSRRKAKNAGRKVSEYGMQLREKQKAKFIYGVLEKPFRNYYKKAERQKGMTGENLMIMLELRLDNVLFRLGFARTRKEARQIVDHKHVLVNGKCVNIPSYLVKAGDVIEIREKSKSSARYKEILESTNGRLVPEWLEADADALKGSVKSIPTREVIDVPVNEMLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RLMH_LACLA
Sequence: MKIKLVVVGKLKEKYLKDGIAEYVKRMGTMLPLEIIELADEKIPDNASEKEAEALKKREGEKILSRIQAGDQLAILAIQGKLMSSEEVADFVKKAEVYGTGNLVFVIGGSLGLSKEVYQRSDLQISFGRMTLPHQLMRLVLVEQIYRAQMINRGSAYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDC6K_HALMA
Sequence: MGMFERDTEIYLDRDALREDYQPENLVGRDTELNRYRAALQPVINGEQPNNIFLYGKTGVGKTAGTRYLIDHLEEDAAKYEDIDLTVKMLNCDGLSSSYQIATRLVNEFRDETSQISTTGYPRATVYDMLWTELDSCGGTIYIVLDEVDHIEDDSILYQLPRARANDNLSSAKIGIIGISNDFSFRDDLSPKVKSSLCEEEIQFPAYDAKELIQILQQRADVAFHDGVLEDGVIELCAAYGAKDAGDARQSLDLLMKTGDLARDKDTDTISEDLVREARDVLERGRIQEGISGLTQHGHLVVYAMVTLDQEGKTPARTRDIRPRYTNFAEKAGIDPLVPRRMRDHLGELSMLGIISAIERNEGRRGGTYREYSLEMDPEMILAALEKTVDDVGIHKSVTNLVDAEATLSDFQST
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein 11.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: RRN3_HUMAN
Sequence: MAAPLLHTRLPGDAAASSSAVKKLGASRTGISNMRALENDFFNSPPRKTVRFGGTVTEVLLKYKKGETNDFELLKNQLLDPDIKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDDNLPANFDTCHRALQIIARYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVNASRQGIEDAEETATQTCGGTDSTEGLFNMDEDEETEHETKAGPERLDQMVHPVAERLDILMSLVLSYMKDVCYVDGKVDNGKTKDLYRDLINIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNNQDSGTKAFCDVALHGPFYSACQAVFYTFVFRHKQLLSGNLKEGLQYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTIIERNNRQMLPVIRSTAGGDSVQICTNPLDTFFPFDPCVLKRSKKFIDPIYQVWEDMSAEELQEFKKPMKKDIVEDEDDDFLKGEVPQNDTVIGITPSSFDTHFRSPSSSVGSPPVLYMQPSPL
What is the function of this protein?
Required for efficient transcription initiation by RNA polymerase I.  Required for the formation of the competent preinitiation complex (PIC).  Dissociates from pol I as a consequence of transcription.  In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).
What are the official names of this protein?
RNA polymerase I-specific transcription initiation factor RRN3, Transcription initiation factor IA, TIF-IA.
What is the protein family that this protein belongs to?
Belongs to the RRN3 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NQOR_BRUA1
Sequence: MVKMLVLYYSAYGYMEQMAKAAAEGAREGGAEVTLKRVPELVPEEVAKASHYKIDQEVPIATPGELADYDAIIIGTATRYGMMASQMKNFLDQTGGLWAKGALINKVGSVMVSTATQHGGAELALISTQWQMQHHGMIIVPLSYAYREQMGNDVVRGGAPYGMTTTADGDGSRQPSAQELDGARFQGRRVAEITAKLHG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: KTHY_FRATH
Sequence: MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDEEIHSDSELLMIYAGRVQHYRNLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRALNDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAGLEFFNRTRKVFKDLVKDLDNAIEIDAAKSIQEVEKQIYLILDKHFNFQN
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: VWA7_MOUSE
Sequence: MLPVEVPLSHLGPPILLLLQLLLPPTSAFFPNIWSLLAAPGSVTHQDLTEEAALNVTLVLFLEQPHPGRPRLHVEDYRGRTLLADDIFAAYFGPGFSSRRFRAALGEVSRANAAQDFLPAFKSNPDLHFDAERLVQGRTRLVGALRETLVAARALEYTLARQRLGAALHALQDFYSHSNWVELGERQPHPHLLWPRQELWSLAQVGDPTCSDCEGLSCPGNMLDSTLLTSGYFGMHPPKPPGKCSHGGHFDQSSSQPPRGGINKDSTSPSFSPHHKLHLQAAEVALLASIEAFSLLRSRLGDKAFSRLLDITPASSLSFVLDTTGSMGEEINAAKIQARRIVEQRQGSPMEPVFYILVPFHDPGFGPVFTTSDPDSFWQKLNEIHALGGGDEPEMCLSALELALLHTPPLSDIFVFTDASPKDALLTNRVESLTRERRCRVTFLVTEDPSRTGGRRRREALSPLRFEPYEAIARASGGEVIFTKDQYIQDVAAIVGESMAGLVTLPLDPPVFTPGEPCVFSVDSLLWQVTVRMHGDISSFWIKSPAGVSQGPEEGIGPLGHTRRFGQFWTVTMTDPPRTGTWEIQVAAAGTPRVRVQAQTSLDFLFHFGISVEDGPHPGLYPLTQPVAGLQTQLLVEVTGLTSRQKLVGGQPQFSHVVLRRVPEGTQLGRVSLEPVGPPVRGLLAASLPPTLLSVSSPFSLELVGQGGGGESLRRTAPQPCSVAPVLLELSGPPDFLTPGSKAPLSLHIVSFSGPQDLDLRTSVNPSFSLTSNLSRARLGLNESAWGRLWLEVPDSAAPDSVVMVTVTAAGQGASQVPPTHAFLRLLVLAQSSKDQLDGPAHSAAPVLPPVSPALLPSTLVTQGRAGGGMAGKAWWGTVGGVLFLLGCTSW
What are the official names of this protein?
von Willebrand factor A domain-containing protein 7, Protein G7c.
What are the subcellular locations of this protein?
Secreted.
Protein: URE1_HELPH
Sequence: MKKISRKEYASMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKFMLRAAEEYSMNFGFLAKGNVSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNSETYHVFVDGKEVTSKPANKVSLAQLFSIF
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELPL_HUMAN
Sequence: MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
What is the function of this protein?
(Microbial infection) Acts as a receptor for enterovirus 71.
What are the official names of this protein?
P-selectin glycoprotein ligand 1, PSGL-1, Selectin P ligand.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL35_BUCA5
Sequence: MPKIKTLKSAAKRFKITASGKFKRKQANLRHILTKKTTTKKRHLRPKILVSTGDMDRVKSFLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: Y1199_SHESM
Sequence: MESLQNHFLIAMPSLDDTFFERTVIYLCEHDEKGAMGLVINKPLGIEVNSLLEQMDLPAEQVSTDLALGAQVLMGGPVSQDRGFVLHTSQPYWANSTELSSGLMLTTSRDVLTAIGSERSPEKFIVALGYAGWSKNQLEQELADNSWLTIPADQALLFDVKHEDRWQQASRALGFDAWQLSSQAGHA
What are the official names of this protein?
UPF0301 protein Shewmr4_1199.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: CVFB_STAAS
Sequence: MALDKDIVGSIEFLEVVGLQGSTYLLKGPNGENVKLNQSEMNDDDELEVGEEYSFFIYPNRSGELFATQNMPDITKDKYDFAKVLKTDRDGARIDVGLPREVLVPWEDLPKVKSLWPQPGDHLLVTLRIDRENHMYGRLASESVVENMFTPVHDDNLKNEVIEAKPYRVLRIGSFLLSESGYKIFVHESERKAEPRLGESVQVRIIGHNDKGELNGSFLPLAHERLDDDGQVIFDLLVEYDGELPFWDKSSPEAIKEVFNMSKGSFKRAIGHLYKQKIINIETGKITLTKKGWSRMDSKE
What is the function of this protein?
Contributes to the expression of virulence factors and to pathogenicity.  Involved in the production of hemolysin, DNase, protease and protein A (By similarity).
What are the official names of this protein?
Conserved virulence factor B.
What is the protein family that this protein belongs to?
Belongs to the CvfB family.
Protein: MURB_LACP7
Sequence: MNNVILQELKNIVSTERVTCNEPLSKHTSFKIGGPADYFVITKKIEETAAVIQCCNQHNLPLLMIGKGSNLLISDAGIRGVVLKQEDNTEGFFVTQCEEGYLVTGGAGMNLSAFAMKIANESLTGFEFAAGIPGSLGGAVYMNAGAYGGEIKDCIKSARVLTKEGQILSLNREELELSYRSSIIQKKGYYVIDATFLLQKGNQEDILRKIEELNQARKDKQPLEYPSAGSTFKRPEGYFAGKLIMDAGLRGYRVGGAMVSEKHCGFVINTGDATAKDVLQLIDDVRRIVKEKFGVTLEPEVRLIGEKVNP
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_ECODH
Sequence: MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBX32_RAT
Sequence: MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGTFVSDLSSYCNKENLFNSLNYDVAAKKRKKDIQNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETTLHWQQQLNSIQISRPAFKGLTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRREQYGVTLQLCKHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy.  Recognizes TERF1 (By similarity).
What are the official names of this protein?
F-box only protein 32, Atrogin-1, Muscle atrophy F-box protein, MAFbx.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and the nucleus.
Protein: ZDH21_BOVIN
Sequence: MGLRIHFVVDPHGWCCMGLIVFVWLYNFFLIPKIVLFPHYEEGHIPGILIIIFYGIAMFCLVALVRASITDPGRLPENPKIPHGEREFWELCNKCNLMRPKRSHHCSRCGHCVRRMDHHCPWINNCVGEDNHWLFLQLCFYTELLTCYALMFSFCHYYYFLPLKKRNLDLFVVRHELAIMRLAAFMGITMLVGITGLFYTQLIGIITDTTSIEKMSNCCEEISRPRKPWQQTFSEVFGTRWKILWFIPFRRRQPLRVPYHFANHV
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity).  Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane.  This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).  Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation.  Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium.  Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction.  May also palmitoylate eNOS and LCK (By similarity).
What are the official names of this protein?
Palmitoyltransferase ZDHHC21, Zinc finger DHHC domain-containing protein 21.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RUVC_DESVH
Sequence: MAASVTVIGIDPGSQCTGWGIVREASGVLTLVDCGAIRPKGGDFAARLGDLYRQLADVVRAHTPDEAAVEDVHAAQNVATALKLGQARGVVVAACAAHGVPVIDYRPSVIKKALVGTGRAEKEQVGYMVGQVLGVRPDWKLDTGDALAAAICHLNQRRLTRLAGLA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: PIRK5_CHICK
Sequence: MQHTTCTEDRIYHALERCLHGLSRDAVSSRWAAGLCLNCWSLQELVSRDAGNYLILVEKILGKAREVQEKCDYDLVMPLALLFYYAVLYAPHIPPDSELLLKAASIYHSFLTWPVPYCDVFRELLTFISDELKAPGISFQRLVRTEQGLPVKNYQSSTVTVLLLNRSEVQSEFLSIAEKLSSTEPPRHATLVLLLEHLYQVTFGTRCDLGSLHHLLKAKTLEELSEIYTSAAEAQEIAAASSDPVLARERLQSALRDIAGAAALPTIAGDAQPRRLQPIPIPTSRCYTYSWDQDNFDVLNDVLSKECSVVEPVASENEEDEEEEEEDVETDGCSPERDSLLSPISSISKDSVYSALSEDGPKHSCVSLFSSSKDSISELTVVSKKSLRSFVSSLKDCMDSGYAEDSDESSLDTLGRPELKVEKTHHKYRHTLTNKIYKLFKSKSQLVLRRDLKDCVDTGSLPLRRAESLCHPQAKPRIPARSRRAHSLPQHGLGQKLQTPQTPQLLSLPRRPFLSYDEDAKVATMRVVVFGSDRISGKVARAYSNLRLKESTCPTLTRYFKLQFFYVPVKRSCLLPAALLMHPPPSPSDLQLRALAQAEPTLAGAESSTNDISHYIGMLDPWYERNVLGLMNLPMDVLCQSAKPEAEPQEDSREQLPILADMILYYCRFATRPVLLQLYQTELTFIGGEKMTEVFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAIPLTLQIAYSKTAISGRSQWNDVEKVCTSVNLSKACKKYEELASKTECLNLTMTEVVKRQNSKSKKSFNQLSVSQIKVDKVQIIGVQSSFAVCLDQDEQKILQSVTRCEISVCYRPRDSDPLALRRSSLTPQDPSEFHSLLCLPISTFSGALP
What is the function of this protein?
Regulatory subunit of the PI3K gamma complex.
What are the official names of this protein?
Phosphoinositide 3-kinase regulatory subunit 5, PI3-kinase regulatory subunit 5.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: ENO_BURVG
Sequence: MSAIVDIIGREILDSRGNPTVECDVLLESGTMGRAAVPSGASTGSREAIELRDGEAGRYNGKGVLKAVEHINTEISEAIMGLDASEQAFLDKTLLELDGTDNKSRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQLPVPMMNIVNGGAHANNSLDIQEFMIVPVSQPTFREALRCGAEVFHALKKILSDRGMSTAVGDEGGFAPNFGSNDECLSTILQAIEKAGYRAGEDVLLALDCAASEFYHDGKYQLAGEGLQLSSAEFTDYLATLADKFPIVSIEDGMHEGDWDGWKLLTERLGKKVQLVGDDLFVTNTRILKEGIEKGIANSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGLNAGQIKTGSLSRSDRISKYNQLLRIEEDLGDIASYPGKSAFYNLR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL24_CHLSY
Sequence: MHVKTGDEVLVIAGKDKGRRGKIKRALPAVNRVVVEGINIVKRHQKPRGPGRPGGIIEMEAPLHASNVMLICPSCGRASRTGKRFLEETDHKGRPRKVRYCKACDAVIDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: HIS7_LEPIN
Sequence: MTDKLIGFYDPVRMKAERKTSETEIKLEMNLRGTGQYQFDTEIPFFEHMLSHISKHGLIDLNLWLRGDIEIDCHHSVEDTAILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLGGRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLHVVVHYGDNKHHVHESIFKALGKALRMAIAQDSAAAGAIPSTKGVLE
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_EXIS2
Sequence: MAVVIDGKQVAQSYRLKLKEEVARLKEERIQPKLTVILIGEDPASQSYVRGKEKAAQEIGMDSDLIRLPEETKESELLHLIERLNADASVHGILVQLPLPKHIDESKVIFAIAPEKDVDGFHPVSVGKMMIGEPTFLPCTPNGILHLVKEMNVPIAGRHVVVVGRSQIVGKPVGMLFLNESATVTYCHSKTADLGAMTRQADILIVAVGVPKLITADMVKPEAVVIDVGVNRVDGKLVGDVEFEAVKEVASMITPVPGGVGPMTITMLLHNTIEAAK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ARGJ_STRMU
Sequence: MKIIDGNIASPLGFSADGLHAGFKKRKKDFGWIVSEVPASVAGVYTTNKVIAAPLIVTRESVKKAQKMQALVVNSGVANSCTGLQGMEDAYTMQKWTATKLKIAPELVGVASTGVIGDLMPMDTLQKGLSKLVVNGNSDDFAQAILTTDTKVKTVAVTEQFGRDEVTMAGVAKGSGMIHPNMATMLAFITCDAVISSETLQLALSQNVETTFNQITVDGDTSTNDMVLVLSNGCTLNKEILPDTPEFDKFSAMLHFVMQELAKKIAKDGEGATKLIEVEVINAPNSLDACMMAKSVVGSSLVKTAIFGEDPNWGRILAAVGYAGVDVPVDNIDIYLADIPVMLASSPVDFDEEDMQDVMRADTIKIIVDLHAGDSVGKAWGCDLSYDYVKINALYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_BACMK
Sequence: MNMKEISKVVDLVRESNPLVHNITNVVVTNFTANGLLALGASPVMAYAKEEVAEMASIAGALVLNMGTLRPEEVEAMLLAGKSANKNDVPVLFDPVGAGATSYRTEVARYIPAEIDLAVIRGNAAEIANVINEKWEIKGVDAGTGNGNVVNIAKQAADELNTVAVITGQEDVVTDGERTILIRNGHPILTKVTGTGCLLTSVIGAFVAVEKDYVKAAVAALTFYGVAAEIAASKTVENGPGSFQIEFLNQLANTTSDDIEKYGKIEVIQ
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: PAI1_MOUSE
Sequence: MQMSSALACLILGLVLVSGKGFTLPLRESHTAHQATDFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGTAHALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSEVERARFIINDWVERHTKGMINDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEASTHQRLFHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQRDTLSMFIAAPFEKDVHLSALTNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSLSDQEQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVRHNPTETILFMGQVMEP
What is the function of this protein?
Serine protease inhibitor.  Inhibits TMPRSS7.  Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).  As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots.  As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading.  Acts as a regulator of cell migration, independently of its role as protease inhibitor.  It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity).  Involved in cellular and replicative senescence (PubMed:16862142).  Plays a role in alveolar type 2 cells senescence in the lung (PubMed:28722352).  Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).
What are the official names of this protein?
Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.