PharMolix/UniProtQA huggingface dataset:
Protein: ATG12_CAEEL
Sequence: METETATTPTGNTEPTAAASAEPPKSDKVTVRLRNIADAPVLKNKKMVVNPTDTVASFILKLRKLLNIQANNSLFLYIDNTFAPSPDTTFETLSRCYSVKITDKEILELQYSITPAYG
What is the function of this protein?
Ubiquitin-like protein involved in autophagy vesicles formation (By similarity).  Conjugation with atg-5 through a ubiquitin-like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity).  Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane (PubMed:26687600, PubMed:28758895).  Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzyme promoting atg-3-mediated lgg-1 lipidation (Probable).  Involved in the degradation of P-granules by autophagy in somatic cells (PubMed:19167332).  This ensures exclusive localization of the P-granules in germ cells (PubMed:19167332).  Involved in the elimination of paternal mitochondria in fertilized eggs (PubMed:22105480).  Involved in xenophagy, the autophagy-mediated degradation of pathogens and pathogen products, such as toxins (PubMed:27875098).  Also plays a role in membrane-pore repair (PubMed:27875098).
What are the official names of this protein?
Ubiquitin-like protein atg-12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Recruited to the membrane of autophagic vesicles.
Protein: WZYE_ECOLI
Sequence: MSLLQFSGLFVVWLLCTLFIATLTWFEFRRVRFNFNVFFSLLFLLTFFFGFPLTSVLVFRFDVGVAPPEILLQALLSAGCFYAVYYVTYKTRLRKRVADVPRRPLFTMNRVETNLTWVILMGIALVSVGIFFMHNGFLLFRLNSYSQIFSSEVSGVALKRFFYFFIPAMLVVYFLRQDSKAWLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGMNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYDNIDFQGLAPIVRDFYVFIPSWLWPGRPSMVLNSANYFTWEVLNNHSGLAISPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNREPNRYKAAILHSFCFGAIFNMIVLAREGLDSFVSRVVFFIVVFGACLMIAKLLYWLFESAGLIHKRTKSSLRTQVEG
What is the function of this protein?
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.  Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC)).
What are the official names of this protein?
Probable ECA polymerase.
What is the protein family that this protein belongs to?
Belongs to the WzyE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NIP51_ARATH
Sequence: MAPPEAEVGAVMVMAPPTPGTPGTPGGPLITGMRVDSMSFDHRKPTPRCKCLPVMGSTWGQHDTCFTDFPSPDVSLTRKLGAEFVGTFILIFTATAGPIVNQKYDGAETLIGNAACAGLAVMIIILSTGHISGAHLNPSLTIAFAALRHFPWAHVPAYIAAQVSASICASFALKGVFHPFMSGGVTIPSVSLGQAFALEFIITFILLFVVTAVATDTRAVGELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVASGNYRSLWVYLVAPTLGAISGAAVYTGVKLNDSVTDPPRPVRSFRR
What is the function of this protein?
Boric acid transporter.  Low water transport activity.  Plays an important role as plasma membrane boric acid channel for the boron uptake required for plant growth and development under boron limitation.
What are the official names of this protein?
Probable aquaporin NIP5-1, NOD26-like intrinsic protein 5-1, AtNIP5;1, Nodulin-26-like major intrinsic protein 6, NodLikeMip6, Protein NLM6.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. NIP (TC 1.A.8.12) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: XAMOE_XANP2
Sequence: MTQQRPTRTRERKKTWTAFGNLGRKPTDYEVVTHNMNHTMRGTPLELSPTVHANVWLKKNRDEIALKVDSWDLFRDPDRTTYDTYVKMQDDQETYVDNLLLSYTGEGRYDEELSSRSLDLLSAGLTPTRYLGHGLQMLAAYIQQLAPSAYVGNCAVFQTSDALRRVQRVAYRTRQLADAHPARGFGSGDRAVWEKSPDWQPIRKAIEELLVTFEWDKALAGTNFVVKPILDELFLNHLARLLHVEGDELDSLVLRNLHGDAQRHARWTAALGRFAVEQNVNNRTVLRDAIAGWHETGEAVLAAGAGMLASRAPSADAAKIADEVRATLAQLHANAGLGHDA
What is the function of this protein?
Component of the alkene monooxygenase multicomponent enzyme system which catalyzes the O2- and NADH-dependent epoxidation of short chain (C2 to C6) alkenes to their corresponding epoxides (PubMed:10103255, PubMed:1444418, PubMed:9312093).  Also able to catalyze the oxidation of a number of chlorinated alkenes, including trichloroethylene, cis- and trans-1,2-dichloroethylene, vinyl chloride, 1-chloropropylene, 1,3-dichloropropylene and 2,3-dichloropropylene (PubMed:1444418).
What are the official names of this protein?
Alkene monooxygenase system, oxygenase component subunit beta.
What is the protein family that this protein belongs to?
Belongs to the TmoE/XamoE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH1_SHEON
Sequence: MTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWLWQPILQGIILNTRPKKVAKLYQSVWTEQGSPLMVISQCQAQKLATDLSATFNQTIPVELGMSYGNPSIESGFAKLKAQGAERIVVLPLYPQYSCSTVASVFDAVAHYLTRVRDIPELRFNKQYFAHEAYIAALAHSVKRHWKTHGQAEKLILSFHGIPLRYATEGDPYPEQCRTTAKLLAQALGLTDGQWQVCFQSRFGKEEWLTPYADELLADLPRQGVKSVDVICPAFATDCLETLEEISIGAKETFLHAGGEAYHFIPCLNDDELHIELLRLLVQEQTQSWISAE
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase 1, Heme synthase 1, Protoheme ferro-lyase 1.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOI_HELAH
Sequence: MAKQEYKQLPKRAEIHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLPLSPRYRAVHNLQRLLDSGSERCIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGRCIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLTSEQDAKDCSHAEFLGFGFVSPNYNERMQATPLDYVQEPSKEESKKETPTSPEANKGDENV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CBPC1_HUMAN
Sequence: MSKLKVIPEKSLTNNSRIVGLLAQLEKINAEPSESDTARYVTSKILHLAQSQEKTRREMTAKGSTGMEILLSTLENTKDLQTTLNILSILVELVSAGGGRRVSFLVTKGGSQILLQLLMNASKESPPHEDLMVQIHSILAKIGPKDKKFGVKARINGALNITLNLVKQNLQNHRLVLPCLQLLRVYSANSVNSVSLGKNGVVELMFKIIGPFSKKNSSLIKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSSFHFQLPVIPVTGPVAQLYSLPPEVDDVVDESDDNDDIDVEAENETENEDDLDQNFKNDDIETDINKLKPQQEPGRTIEDLKMYEHLFPELVDDFQDYDLISKEPKPFVFEGKVRGPIVVPTAGEETSGNSGNLRKVVMKENISSKGDEGEKKSTFMDLAKEDIKDNDRTLQQQPGDQNRTISSVHGLNNDIVKALDRITLQNIPSQTAPGFTAEMKKDCSLPLTVLTCAKACPHMATCGNVLFEGRTVQLGKLCCTGVETEDDEDTESNSSVEQASVEVPDGPTLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERLIHQSDIIDRVVYDLDNPNYTIPEEGDILKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWIRMGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQMHLQKLESAHNPQQIYFRKDVLCETLSGNSCPLVTITAMPESNYYEHICHFRNRPYVFLSARVHPGETNASWVMKGTLEYLMSNNPTAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPSPDLHPTIYHAKGLLQYLAAVKRLPLVYCDYHGHSRKKNVFMYGCSIKETVWHTNDNATSCDVVEDTGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGKYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEYNLPSSLLDFENDLIESSCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELDIELAENVGDYEPSAQEEVLSDSELSRTYLP
What is the function of this protein?
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557).  Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557).  Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482).  Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066).  Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216).
What are the official names of this protein?
Cytosolic carboxypeptidase 1, ATP/GTP-binding protein 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, Protein deglutamylase CCP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Nucleus. Mitochondrion. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells.
Protein: NU3C_LOTJA
Sequence: MFLLYEYDIFWAFLIISIFIPILAFTISGFLAPINKGPEKLSSYESGIEPMGDAWLQFQIRYYMFALVFVVFDVETVFLYPWAMSFDVLGISVFIEALIFVLILIVGSVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RHL_MACMU
Sequence: MSSKYPRSVRCCLPLWALTLEAALILLFFFFTYYDASLEDQKGLVASYQVCQDLTVMAVLGLGFFTSNLRRNSWSSVAFNLFLLALGVQWAILLDGFLSQFSPGKVAIKLFSIRLATRSTMSMLISMNAVLGKVNLVQLVVMELVELTVFGTMRIVINNIFKIDYGMNMMHIHVFAAYFGLTVAWCLPKPLPKGTEDKYQTTTSPSLFAMLGTLFLWMFWPTFNSALLLNPIERKNAVFSTYYALAVSAVTAISVSSLAHPGGKINMTYMHNAALAGGVALSASCHVIHSPWIAMVLGLVAGLISIGGAKCLPVCFNRVLGIHESHSVHYTFGLPALLGEITYIVLMALRVVWASSNMIGFQVLLSTGTLSLAMAMSITSGLLTGLLLNLKIWKGPHVAKYFDDQAFWEFPHLAVGF
What is the function of this protein?
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
What are the official names of this protein?
RH-like protein, Rhesus-like protein.
What is the protein family that this protein belongs to?
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IF2B_SACS2
Sequence: MSSEKEYVEMLDRLYSKLPEKGRKEGTQSLPNMIILNIGNTTIIRNFAEYCDRIRREDKICMKYLLKELAAPGNVDDKGELVIQGKFSSQVINTLMERFLKAYVECSTCKSLDTILKKEKKSWYIVCLACGAQTPVKPL
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit beta, aIF2-beta, eIF-2-beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: NADK1_STRCO
Sequence: MTIERVGLVVHGGREGAAEAAREVREWCDENAVACTDIDVWSDTGRHSAREEVDAAGDPDLVVTLGGDGTFLRGARLAAENDALILGVDLGRVGFLTEVPAPAVRSALDAVRDGGLEPESRMLLTLRASRLLEIPAEMEALLRYGRGPLLPPPRVRTDCESGDEWGIALNVTALNDVVLEKLSRDRQISVGVYIAGRLLASYSADALLVATPTGSTAYSFAAGGPVVSPRAEALVFTAVAPHMTFDRSVVTAPDEPVGLRILERSGRAAVSIDGQLRGVLDPGDWLGVYAAPRRLRAVRLGPMDFYGRLRERMRLTDAPAAVADGTPAPLWPVSTPPPGDLAHLALPVPGAEGASGDLLREQS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase 1, ATP-dependent NAD kinase 1.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_ECO27
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDATDIQEEWVKEAKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRVDIREVD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: CLC4F_MOUSE
Sequence: MKEAELNRDMARYCTDNQCVSLQPQGLGPKSAALMAPRTLRHVQVILALMVVTVIFSLLALFVVASQPWRPEWNKEPPSLLLRGSNNSGHDNHSQFVRETEMQVAIQRLRDYEENSSSCHKEVQILKYQMDNVSSLVQLLGSHLEDVNADILQTKDVLKESGALALETQALRSSLEVASADIHSLRGDLEKANAMTSQTRGLLKSSTENTSAELHVLGRGLEEAQSEIQALRGSLQSANDLSSQTQGFLQHSMDNISAQIQTVRDGMERAGEKMNSLKKELETLTAQTQKANGHLEQTDAQIQGLKAELKSTSSLNSRIEVVNGQMKDASRELQTLRRDLSDVSALKSNVQMLQSNLQRAKTEMQTLKADLQATKALTAKIQGEQNRLGALQEAVAAQKQEQKTQNQVLQLIAQNWKYFNGNFYYFSRDKKPWREAEKFCTSQGAHLASVTSQEEQAFLVQTTSSGDHWIGLTDQGTEGIWRWVDGTPFNNAQSKGFWGKNQPDNWRHRNGEREDCVHVRQQWNDMACGSSYPWVCKKSTGWSAARVG
What is the function of this protein?
Receptor with an affinity for galactose and fucose.  Could be involved in endocytosis.
What are the official names of this protein?
C-type lectin domain family 4 member F, C-type lectin superfamily member 13, C-type lectin 13, Kupffer cell receptor.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: DLGP5_HUMAN
Sequence: MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRILVELDETSQGLVPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKVGRYRPDMPCFLLSNQNAVKAEPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPRQTSEKKVSDKEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAANENEPEGKVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSGMNPDGVLSKMENLPEINTAKIKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEVDESQATKEILAQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNEGRIAQPHHGVPYFRNILQSETEKLTSHCFEWDRKLELDIPDDAKDLIRTAVGQTRLLMKERFKQFEGLVDDCEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNKNVFRKKVVSGIASKPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVIPKEVDKIVFDAGFFRVESPVKLFSGLSVSSEGPSQRLGTPKSVNKAVSQSRNEMGIPQQTTSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVDCLSSERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEKNTASQNSILEEGETKISQSELFDNKSLTTECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSPLQPGEF
What is the function of this protein?
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells.  Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway.  Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
What are the official names of this protein?
Disks large-associated protein 5, DAP-5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein, HURP.
What is the protein family that this protein belongs to?
Belongs to the SAPAP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Protein: THIE_CLOTE
Sequence: MHNKNLDCTLYLVTDRDILKGRDLKKVLEEAILGGTTLVQLREKNVSSKEFYEIAKDIKVITDKYNIPLIINDRVDIALAVNAEGIHIGQKDLPANIVRKIIGEDKILGVSANTIEDALKAQRDGADYLGVGAIFPTNSKKDAESTSIETLKEIKNAVNIPIVAIGGINENNVQKLKETNIDGIAVISTILGKEDVKKACEELTGFFNE
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: HBB_DASVI
Sequence: VRAHGAKVLVSFGDAVKNLDNLKGTFAKLSELHCDKLHEDPENFKLLGNILVICLAEHFGKEFTPEVQAATQKTVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: BIOB_WOLSU
Sequence: MKDIFLCSICNVSSGGCAEDCAYCTQSAKYRVDIEKYKQKSLENILEEARRARASGALGFCLVTAGRSLDSAKTAYISEAARSIKEAGLELHLIACCGSATKEALAELKKNGVDSYNHNLETAKSFFPKICTTHSWEERYETCESALEVGLGLCTGGIFGLGEGWSERLEFLHALQTLSPHSVPVNFYIPNPSLPLEVEALAQEEALECVRLAREYLPSARLMIAGGREKVFGQAQKPLFEAGINAVVLGDYLTTKGNRPSEDIAMIRSFGFEIAEACH
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: PSBN_OENPA
Sequence: METATLVAISISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ACCA_SALPC
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQVAQLARHPKRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLEGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMAERFNMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLNVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLEDLADLDVLSTDDLKNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_SHEPW
Sequence: MSKRDFYEVLGVGRDASEREVKKAYKRLAMKFHPDRNPGDKEAEASFKEVKEAYEILTDSDKKAAYDQFGHAGVDPNRGGGGHGGADFGDVFGDVFGDIFGGGRRGGGQRQAARGSDLRYNLELSLEEAVKGLSKELRIPTLVACEPCDGSGAKKGSKPTTCGTCHGQGQVQMRQGFFAVQQACPTCHGRGKIIKDPCNKCHGEGRVEKSKTLSVKIPAGVDTGDRIRLSGEGEAGEFGAPPGDLYVQVSVREHAIFQRDGNNLYCEVPISFSKAALGGEIEVPTLDGKVNLKIPTETQTGRMFRMRGKGVKSVRSHAVGDLLCKVVMETPVNLNERQKELLREFEETLTGQSKKHSPKAEGFFDGVKKFFQDLNS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRD8_HUMAN
Sequence: MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVNESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFMGHEWVWLDSEQDHPNDSELSNDCRSLFSSWDSSLDLDVGNWRETEDPEAEELEESSPEREPSELLVGDGGSEESQEAARKASHQNLLHFLSEVAYLMEPLCISSNESSEGCCPPSGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKPLGENGKPEVASAPSVICTVQGLLTESEEGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPLVDTLFSHATSSKLTDLSQDDPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGYKDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEVLEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF
What is the function of this protein?
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR).  Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2.  At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.  This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.  NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.  Component of a SWR1-like complex that specifically mediates the removal of histone H2A. Z/H2AZ1 from the nucleosome.
What are the official names of this protein?
Bromodomain-containing protein 8, Skeletal muscle abundant protein, Skeletal muscle abundant protein 2, Thyroid hormone receptor coactivating protein of 120 kDa, TrCP120, p120.
What are the subcellular locations of this protein?
Nucleus.
Protein: YNB3_YEAST
Sequence: MLTSKIYKLLTERDVLDFKLKIFIRRNVFITHLFFLLHSLLLFLSQFCRREFAFFLPTINLVTHSIKFITLFFFFLNSWASTLSCNPIMARGCHFPILNRPNFVSQILSKFCRMRNNNDTTFKSF
What are the official names of this protein?
Putative uncharacterized protein YNL013C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.