PharMolix/UniProtQA huggingface dataset:
Protein: CSPL7_POPTR
Sequence: MESQNKASLPVMDGLERRVVASQSEGASTCDLLLRVLALVLTLAAAIVLGVDKQTKVVPIKIVDTLPAINLPVSAKWHYLSAFTYSVASNAIACSYAALSLVLAVSGKKGIMSIVIVLDLLMVAMLFSSNGAALAIGLMGYQGNSHVRWTKVCHVFGRFCNQVAVSISLSLLGSILFLLLVGITSLRLHKKSK
What are the official names of this protein?
CASP-like protein 1E1, PtCASPL1E1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HPRK_XYLFM
Sequence: MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: PUR7_STAES
Sequence: MSLLYEGKAKRVFTTNIDGQLRVEYKDEVTAGNGAKKDTMIGKGKLNNQITSIIFDYLTHNHIDNHFIKQLSQTEQLVQQVDIIPLEVVVRNIATGSITKRLGFKKGHTFEEPLVEFFYKKDELNDPLITDDHVKLLGIANDEEIKQLKQMAKDINQVLIQLMNEMSLRLVDFKVEFGKTNGGKILLADEISPDTCRIWDKNTDTNFDKDVYRNNTGSLIETYQTFLNKLEDLK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: AGRG1_PANTR
Sequence: MTAQSLLQTTLFLLSLLFLVQGAHGRGHREDFRFCSQRNQTHRSSLHYKPTPDLRISIENSEEALTVHAPFPAAHPASQSFPDPRGLYHFCLYWNRHAGRLHLLYGKRDFLLSDKASSLLCFQHQEESLAQGPPLLATSVTSWWSPQNISLPSAASFTFSFHSPPHTAAHNASVDMCELKRDLQLLSQFLKHPQKASRRPSAAPASQQLQSLESKLTSVRFMGDTVSFEEDRINATVWKLQPTAGLQDLHIHSRQEEEQSEILEYSVLLPRTLFQRTKGRRGEAEKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVDNLTEPVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPGHWSSAGCETVRRETQTSCLCNHLTYFAVLMVSSVEVDAVHKHYLSLLSYVGCVVSALACVVTIAAYLCSRRKPRDYTIKVHMNLLLAVFLLDTSFLLSEPVALTGSEAGCRASAIFLHFSLLACLSWMGLEGYNLYRLVVEVFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDVDNYGPIILAVHRTPEGVIYPSMCWIRDSLVSYITNLGLFSLVFLFNMAMLATMVVQILRLRPHTQKWSHVLTLLGLSLVLGLPWALIFFSFASGTFQLVILYLFSIITSFQGFLIFIWYWSMRLQARGGPSPLKSNSDSARLPISSGSTSSSRI
What is the function of this protein?
Receptor involved in cell adhesion and probably in cell-cell interactions.  Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells.  Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination.  Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12.  Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche.  Plays an essential role in testis development.  Plays a critical role in tumourigenesis.
What are the official names of this protein?
Adhesion G-protein coupled receptor G1, G-protein coupled receptor 56.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [ADGRG1 N-terminal fragment]: Secreted. SUBCELLULAR LOCATION: [ADGRG1 C-terminal fragment]: Membrane raft. Note=Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts.
Protein: MSHC_STRAW
Sequence: MHAWPASEVPALPGEGRDLRIHDTATGGVIPLHPGPVARIYVCGITPYDATHMGHAATYNAFDLVQRVWLDTKRQVHYVQNVTDVDDPLLERAERDGVDWVGLAEKETALFREDMTALRMLPPQHYIGAVEAIPGIVPLVERLRDAGAAYELDGDVYFSVEADPHFGKVSNLDAAAMRLLSAERGGDPDRPGKKNPLDPMLWMAAREGEPSWDGASLGRGRPGWHIECVAIALDHLGMGFDVQGGGSDLAFPHHEMGASHAQALTGEFPMAKAYVHAGMVALNGEKMSKSKGNLVFVSKLRRDGVDPAAIRLALLAHHYRSDWEWTDAVLEEALARLGTWRAAVSRPDGPPAEALVEEIRDALANDLDAPAALAAVDRWAALQHERGGTDEGAPGVVSRAVDALLGVAL
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: ANMK_CHRSD
Sequence: MPLYIGLMSGTSLDGIDAALVRCGEGRPEWLGATGLPFSAALHDDLLALCLAREVSFAELARLETAFCERQAEAVNRLLLETGTPREAITAIGSHGQTIEHAPNATPAHTYQLDNPSLLAELTGCAVVGDLRRRDLAAGGQAAPLAPAFHAALFTASEAYRLVLNLGGIANLTRLPPSGQAAPVVGFDTGPANMLMDAWSQRHLGHPYDADGAWAASGRVDDALLARLLDDDYFSRLPPKSTGREHFHLDWLTSRLSGHESPCDVQATLAELTAASIAMGVTQCSAGVSTAYDALIPCGGGAHNADLLTRIQRHLPEIPLTPCERFGWSPDWLEAGAFAWLAHQRVAGLPGNLPDVTGARGPRVLGGLYAG
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: TM256_HUMAN
Sequence: MAGPAAAFRRLGALSGAAALGFASYGAHGAQFPDAYGKELFDKANKHHFLHSLALLGVPHCRKPLWAGLLLASGTTLFCTSFYYQALSGDPSIQTLAPAGGTLLLLGWLALAL
What are the official names of this protein?
Transmembrane protein 256.
What is the protein family that this protein belongs to?
Belongs to the TMEM256 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TPIS_DICTD
Sequence: MRRKIIAANWKMYKTCAETESFIKEFKELSKGYEEKEIVICPPFTSLYVANKLLEDTPIKLGAQNMFWEKEGAYTGEISPIMLKDLNCSYVIIGHSERRQYFSETNDMINKKLKSAFEYELIPIFCVGEKWEEREKGKTEEVITEQVKKGLQGLEKEKVEKIVIAYEPVWAIGTGHSAKGEDANEVAKLIRRIISEIYDEEVSQKVRIQYGGSVNPQNIKEFLAQSEIDGALVGGASLKPQSFWDIVRS
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMC_ACIAD
Sequence: MCVSSSIQTAILDWQCVDGIDIPVSRQFGDVYFSKDNGLLETRHVFLNGNNLTERLADLKPYQYFCVGETGFGTGLNILAVWQLWQQVRPDNHSHLHVISVEKFPLSKSDLERALRAWPELIILAEQLIEQYPFPIAGCHRLNFPDERFSLDLWLGDAHDVFPSIVKTHSVDAWFLDGFAPSCNPELWETQVLNQIVRLSDYGTTFASFSVAGILKRGLKAHGIHISRPRGFGHKREMLKAIWPFPDHESTTTVKGNQPSTQQHFAVIGAGIAGLHCAWSLAQRGHRVTLVDQSQPLSGASGNPLALLNPKLCPITQCHDHLMVLCWQYARRFYQNFEAFRLIQVNQLALKASDSLLNLAEQYPKDVLDAHSAQQSPLETQYDYLTLHYAGVISPQLFCNQVLQHPLIEFKQFKINQIIEIDGTVQLLSSEQAILESNAAIVCCARESGKLFEQYPTLKPIRGQVSWFEQHTFPFAPDQAFSYGGYCMQLHPQQLILGASFHPQRDDDEVLLEDHVHNFNLIHSVFPAYAQTLPPVEEWHGRASVRAQSPDYFPLVGQLQDHSKLFTLAGLGSKGYLFAPLNSEILVAHILGEACPVSANLLQKLNPQRFLKKVKIKKPYYSS
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGNB2_HUMAN
Sequence: MARLVAVCRDGEEEFPFERRQIPLYIDDTLTMVMEFPDNVLNLDGHQNNGAQLKQFIQRHGMLKQQDLSIAMVVTSREVLSALSQLVPCVGCRRSVERLFSQLVESGNPALEPLTVGPKGVLSVTRSCMTDAKKLYTLFYVHGSKLNDMIDAIPKSKKNKRCQLHSLDTHKPKPLGGCWMDVWELMSQECRDEVVLIDSSCLLETLETYLRKHRFCTDCKNKVLRAYNILIGELDCSKEKGYCAALYEGLRCCPHERHIHVCCETDFIAHLLGRAEPEFAGGRRERHAKTIDIAQEEVLTCLGIHLYERLHRIWQKLRAEEQTWQMLFYLGVDALRKSFEMTVEKVQGISRLEQLCEEFSEEERVRELKQEKKRQKRKNRRKNKCVCDIPTPLQTADEKEVSQEKETDFIENSSCKACGSTEDGNTCVEVIVTNENTSCTCPSSGNLLGSPKIKKGLSPHCNGSDCGYSSSMEGSETGSREGSDVACTEGICNHDEHGDDSCVHHCEDKEDDGDSCVECWANSEENDTKGKNKKKKKKSKILKCDEHIQKLGSCITDPGNRETSGNTMHTVFHRDKTKDTHPESCCSSEKGGQPLPWFEHRKNVPQFAEPTETLFGPDSGKGAKSLVELLDESECTSDEEIFISQDEIQSFMANNQSFYSNREQYRQHLKEKFNKYCRLNDHKRPICSGWLTTAGAN
What is the function of this protein?
May be involved in spermatogenesis.
What are the official names of this protein?
Gametogenetin-binding protein 2, Laryngeal carcinoma-related protein 1, Protein ZNF403.
Protein: HSLU_PSYIN
Sequence: MSNMTPKEIKHELDRHIIGQDNAKRAVAIALRNRWRRMQLDKEMRQEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVESIVRDLVDVAIKLTREEEMAKVAHKAEDLAEDRILDILIPPAKTGNDWETVKTEDSATRQSFRKKLREGKLDDKEVEIDLPAPQIGVEIMAPPGMEEMTNQLQGMFQSMSGKDKTKKRKMKIKEALKVLIESEAAKLVNEEDIKEKALFSAENNGIIFIDEIDKICKRGDSAGPDVSREGVQRDLLPLIEGSTVSTKHGMVKTDHMLFIASGAFQVAKPSDLIPELQGRLPIRVELEALTEEDLAKILTEPKASLSEQYKALLATEGITLQFSKDGIDKIAKSAWHVNETTENIGARRLHTLMERILDELSYEASERKGESITIDENYVANTLDDLLENEDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYT1_XENLA
Sequence: MNVDNVNKGTHTRSKASRVIPSDLIEQEVSLESCPLSRKRKLQESEQENPLSKRKSHPLKLALDEGFNVDSNGSEETEMKERDSGTEESEATLEEIEEDSEPTKPKEAPSPQTAEAESSDKVEPEETETKTESSPPAKATYSSYHEIIANSLLNLGQVAKEALVSEGHLKESELNNEKPTSVKSGQAEIEQLMVEEACEKEIIIQTEDAEEVIEVTSEPISESGTEPRDEVNCEDTEKLQKDMIDEEEEEEDDDVDEEDDDDLEEDEEEEEEHSSEMANQDLPHASQDSPKPHCEGHFSPKPEYSVIVEVRSDDDKDDDSHSQKSAVTDESEMYDMMTRGNLGLLEQAIALKAEQVKVVREPSRSSLDNMKNFSADEKQNRPIDTMRKSFYDAGRPEKRDIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLTRSHEKQQQPGDLSKSSSNSDRILRPMCFVKQLEIPQYGSYRPNMAPATPRANLAKELEKYSKVTFDYASFDAQVFGKRLLAPKIPSSETSPKAFKSKPFPKASSPCHSPSSSYIKSTSSSSSSGFDYTHDAEAAHMAATAILNLSTRCWEMPENLSTKQQDTPSKSSEIEVDENGTLDLSMNKHRKRESTFPSSSSCSSSPSMKSPDQSQRQNCTSATSSNMTSPHSSQTSRQDDWDGPIDYTKPNRQREEEPEEMEPAAASFASSEVDEQEMQEMQEMQEMQEESYEDRKYPGDVTLTNFKLKFLSKDSKKELLSCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGLKITPTKDDKDDPDLMKCPVPGCDGLGHISGKYASHRSASGCPLAARRQKEGALNGSAFSWKSLKTEGPSCPTPGCDGSGHANGSFLTHRSLSGCPRASFAGKKGKISGDELLGTNFKTSDVLENDEEIKQLNKEINELNESNSEMEADMVNLQSQITTMEKNLKNIEEENKVIEEQNEALFVELSGLSQALIRSLTNIRLPQMEPISEQNFDAYVNTLTDMYTNQECYQNPENKALLESIKQAVKGIKV
What is the function of this protein?
Transcriptional activator which is essential for neuronal differentiation.  Can promote ectotopic neuronal differentiation and confers insensitivity to lateral inhibition, but only in cooperation with bHLH transcription factors.
What are the official names of this protein?
Myelin transcription factor 1, X-MyT1.
What is the protein family that this protein belongs to?
Belongs to the MYT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNFH_CUPPJ
Sequence: MAQADMVRISVCYARPDSVFLKEFDVLQGTTIAAAIVSSGVQQVCPEIDPSTMRVGIYGKLKTPDTVVRTGDRVEIYRALTADPKLARRRRVQKTRESGTREGQKWLRGGA
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: MSHA_MYCGI
Sequence: MRLATDPAGSSSGLPQPRRVAVLSVHTSPLAQPGTGDAGGMNVYVLQTSLELARRGVEVEIFTRATSSADQPIVSVAPGVVVRNVVAGPFEGLDKNDLPTQLCAFTAGVLRAEATHEPGYYDILHSHYWLSGQVGWLAADRWAVPLVHTAHTLAAVKNASLAAGDTPEPPMRAIGEQQVVDEADRLIVNTEHEAQQLVSLHHADPGRIDVVHPGVDLATFTPGDRAAARAALGLDPAARIVAFVGRIQPLKAPDVLLRAAALLPDVHVVIAGGPSGSGMATPDNLVHLAGELGIAERVTFLPPQSRDHLVRVYRAADIVAVPSHNESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGVSGALVHSHEPDAWATTLGEVFAADPSTFGRAAVDHAATFSWAHTVDALLTGYGRAIADHRADNTLQVAARRSGRRFSMRRGVRA
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: AMPD1_STEME
Sequence: MAKTVLGIHVTFLTLLFAVLLLNDVMYTPVEKICERASGTWKGICIHSNDCNNQCVKWENAGSGSCHYQFPNYMCFCYFDC
What is the function of this protein?
Antimicrobial peptide probably active against fungi like B. sorokiniana, F. oxysporum, F. graminearum, F. avenaceum, B. cinerea, P. beta, P. infestans and P. debaryanum.
What are the official names of this protein?
Antimicrobial peptide D1, Sm-AMP-D1, Sm-D1.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
Protein: RF2_CAMLR
Sequence: MDNYEYSELLKKLKNKVGNIASIIKPEEIKARLKEIENLENSPSFWSDVKQAGIIGKEKTKISNLLKNYENAFNALNDASELFDLANSENDLDTIQALFDDAPNLEDLIVSLEISMLLSGENDGKNAIVSIHPGAGGTESNDWASMLYRMYLRFCEREGFKVETLDFQEGEEAGLKDVSFLVKGENAYGYLKAENGIHRLVRTSPFDSAGRRHTSFSSVMVSPELDDDIEIEIEDKDIRIDYYRASGAGGQHVNKTESAVRITHMPSGIVVQCQNDRSQHKNKATAFKMLKSRLYELELMKQQDEANSSEKSEIGWGHQIRSYVLFPYQQVKDTRSNEAFSQVDNILDGDIKKMIEGVLIAQKAQD
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RES18_MOUSE
Sequence: MQSSLKPAGSGHLQLLVCFLLLYSRPGSCSDINAHDGQGQVGSEQLWTFQGLIASVFQYLQLIFHQIVPEGMFWADDIAYELMTKKVEHLSRLHPQYPCRKDMKAVSPTANAGVRSKQEEKLQLLSPQKSPTVKVNRDRCFTTKVIPKATKQEATHPTKGFFGPFPTVGLNLVAD
What is the function of this protein?
May play an important regulatory role in corticotrophs.
What are the official names of this protein?
Regulated endocrine-specific protein 18.
What is the protein family that this protein belongs to?
Belongs to the RESP18 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle lumen. Note=Found in the lumen of secretory vesicles (dense core vesicles, DCV) (By similarity). However, seems to be retained intracellularly and not secreted (PubMed:7988462).
Protein: RL29_RUEPO
Sequence: MNAQELRNKTPDQLREDLVTLKKEAFNLRFQQATGQLENNARIRTVRRDVARVMTVLNEKAAEAAN
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: YIHI_ECO7I
Sequence: MKPSSSNSRSKGHAKARRKTREELDQEARDRKRQKKRRGHAPGSRAAGGNTSSGSKGQNAPKDPRIGSKTPIPLGVTEKVTKQHKPKSEKPMLSPQAELELLETDERLDALLERLEAGETLSAEEQSWVDAKLDRIDELMQKLGLSYDDDEEEEEDEKQEDMMRLLRGN
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: IL2RA_MOUSE
Sequence: MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKELVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGHCREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTCVDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVASCLFLLISILLLSGLTWQHRWRKSRRTI
What is the function of this protein?
Receptor for interleukin-2.  The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.  TREGs suppress the activation and expansion of autoreactive T-cells.
What are the official names of this protein?
Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, p55.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TILS_COREF
Sequence: MPASIGGLPLPRICPHFLTLRVAIRAHLTDHVHIGLSGGPDSLALVAAARAEGAEVTAICINHNLQEGSAEVSERAAAQAEHMGATALIRSITVPPGSMEAQAREARYAEFAQLTDTIWAGHTMDDQAETFLLAGLRGNPAGMKSASRRPDLTVIRPLLGVRRADTHGACTELGLTPWQDPQNRDRAFRRVAIREQVLPLLAEIHAGDPVPGLALAATRAAMEGEALEFFVDKRRGEWADGFPVRLAAEPHALRRLMLADFLRGHGVRVTSKKIEAVDRLLTHWHGQGGVAVGGGAHGRLEVVRVSGKLEITG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_LEUCK
Sequence: MKISTLPQEFMQAQPILEHIESAGFEAYFVGGAVRDMLLNKPIHDVDIATSAFPEEIKALFTKTVDTGIQHGTVMVLDHGDGYEITTFRTESTYTDFRRPDKVTFVRSLAEDLKRRDFTINAIAMTKDGDIIDLFDGLTDMAQKRIRAVGDAEVRFNEDALRIMRALRFSAQLGFDIAPHTKAALKQIGRNLEKIAVERIRVEFEKLLMGQYASNSLSVAIEADLIRYLPGHIKKEDWLTITADLKRNQPQARTVIWPYFLSRLSLRLNELQLFMRSWKTSREDMRAVLSIVPIVKHVQTVSVFELYAIYDYQALLFEVLTLIGTPLATQQRVKQIFDALPITHNRDMCISGGDLLANNIVTPGPQMGRILTQLEHAVIQRIISNRPDSLLEYAKELVDNEKN
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: CCD87_HUMAN
Sequence: MMEPPKPEPELQRFYHRLLRPLSLFPTRTTSPEPQKRPPQEGRILQSFPLAKLTVASLCSQVAKLLAGSGIAAGVPPEARLRLIKVILDELKCSWREPPAELSLSHKNNQKLRKRLEAYVLLSSEQLFLRYLHLLVTMSTPRGVFTESATLTRLAASLARDCTLFLTSPNVYRGLLADFQALLRAEQASGDVDKLHPVCPAGTFKLCPIPWPHSTGFAQVQCSNLNLNYLIQLSRPPEFLNEPGRMDPVKELKSIPRLKRKKPFHWLPSIGKKREIDISSSQMVSLPSYPVAPTSRASPSPFCPELRRGQSMPSLREGWRLADELGLPPLPSRPLTPLVLATESKPELTGLIVAEDLKQLIKKMKLEGTRYPPLDSGLPPLLGVVTRHPAAGHRLEELEKMLRNLQEEEASGQWDPQPPKSFPLHPQPVTITLKLRNEVVVQAAAVRVSDRNFLDSFHIEGAGALYNHLAGELDPKAIEKMDIDNFVGSTTREVYKELMSHVSSDHLHFDQGPLVEPAADKDWSTFLSSAFLRQEKQPQIINPELVGLYSQRANTLQSNTKKMPSLPSLQATKSWEKWSNKASLMNSWKTTLSVDDYFKYLTNHETDFLHVIFQMHEEEVPVEIVAPARESLEIQHPPPLLEDEEPDFVPGEWDWNTVLEHRLGAGKTPHLGEPHKILSLQKHLEQLWSVLEVPDKDQVDMTIKYSSKARLRQLPSLVNAWERALKPIQLREALLARLEWFEGQASNPNRFFKKTNLSSSHFLEENQVRSHLHRKLNLMESSLVSLLEEIELIFGEPVIFKGRPYLDKMKSDKVEMLYWLQQQRRVRHLVSALKDPHQSTLFRSSAASL
What is the function of this protein?
Plays a role in spermatogenesis, where it is important for normal sperm head morphology.  Also required for the acrosome reaction and thus normal male fertility.
What are the official names of this protein?
Coiled-coil domain-containing protein 87.
What is the protein family that this protein belongs to?
Belongs to the CCDC87 family.
Protein: SYFB_HAEIN
Sequence: MKFSEQWVREWVNPAVSTEQLCEQITMLGLEVDGVEAVAGTFNGVVVGEVVECAQHPDADKLRVTKVNVGGDRLLDIVCGAPNCRQGLKVACATEGAVLPGDFKIKKTKLRGQPSEGMLCSFSELGIDVEADGIIELPLDAPIGTDLREYLALDDNAIEISLTPNRADCLSIAGIAREIGVVNKQLVNQLHFEAAPATISDKVQIDLQAPEACPRYLLRVIKNVNVKAPSPMWMQEKLRRCGIRSIDPIVDITNYILLEFGQPMHAFDAAKVTQPVQVRFAKEGEELVLLDGSTAKLQSNTLLIADQNGPLAMAGIFGGAASGVNSETKDVILESAFFAPLAIAGRARQYGLHTDASHRFERGVDFELARKAMERATALLLEICGGEAGEICEASSETHLPKVNTVQLRRSKLDALLGHHIETGSVTEIFHRLGFDVTYANDIWTVTSASWRFDIEIEEDLIEEVARIYGYNSIPNNAPLAHLCMREHKESDLDLARIKTALVDADYQEAITYSFVDPKIQSLLHPHQEALVLPNPISVEMSAMRVSLISGLLGAVLYNQNRQQSRVRLFETGLRFVPDANAEFGVRQEFVLSAVITGTAKSEHWAGKAESVDFFDLKGDLESVLSLTEGGHRVRFVAKQFDALHPGQSAAIELDGQEIGFIGAIHPSISQKLGLNGKTFVFEILWNAIAARNVVQAKEISKFPANRRDLALVVADSVPAGELIAACKQAGGEKLVQVNLFDVYQGVGVAEGYKSLAISLTVQDNEKTLEDEEINAVISAVLAEVKQRFNAELRD
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRC_MOUSE
Sequence: MGSNKSKPKDASQRRRSLEPSENVHGAGGAFPASQTPSKPASADGHRGPSAAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
What is the function of this protein?
Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-418 and subsequent activation (By similarity).  The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity).  Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity).  Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity).
What are the official names of this protein?
Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src, p60-Src.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell junction, focal adhesion. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain. Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions.
Protein: MSRB_ECO81
Sequence: MANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKYDSGCGWPSFYEPVSEESIRYIKDLSHGMQRIEIRCGNCDAHLGHVFPDGPHPTGERYCVNSASLRFTDGENGEEING
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.