PharMolix/UniProtQA huggingface dataset:
Protein: DER_MYCTO
Sequence: MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGLGEPHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDSLIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKWDLVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGKQPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: HUTI_ALTMD
Sequence: MDSKYDTLIYNVRIASMQHNGMPYGELPPTAIAIKEGHIVALLSCDEQLNDALQQTSTVIDGSRLIPCNENEQPTLPWLLPGFIDCHTHLVYGGNRAEEFEMRLQGASYVEIAERGGGIKGTVKKTRQADEQTLLNTAIKRAMRLCEEGVTTIEVKSGYGLDVDTEIRMLSVAKSLEKHLPVTIQTTYLGAHALPNEFNHDADAYIDFICRDALPQIASLGLADAVDVFCETIGFSLQQTERVFSCAKQYGLPVKAHVEQLSDSKGAVLAAKYGALSVDHIEYLVDSDIPSLVKSETVAVLLPGAFYYLSEVQKPPVEALRAHNVPIAVATDFNPGSSPLASLLTALNMSCVLFKLTPEEALRGATEHAASALGLNDRGVVDIGNVADLTLWDIETPAELVYCINGHRPIAVFKDGKHV
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETH2_THEAE
Sequence: MSVTTPRRETSLLSRALRATAAAATAVVATVALAAPAQAANPYERGPNPTESMLEARSGPFSVSEERASRFGADGFGGGTIYYPRENNTYGAIAISPGYTGTQSSIAWLGERIASHGFVVIAIDTNTTLDQPDSRARQLNAALDYMLTDASSAVRNRIDASRLAVMGHSMGGGGTLRLASQRPDLKAAIPLTPWHLNKSWRDITVPTLIIGAEYDTIASVTLHSKPFYNSIPSPTDKAYLELDGASHFAPNITNKTIGMYSVAWLKRFVDEDTRYTQFLCPGPRTGLLSDVEEYRSTCPF
What is the function of this protein?
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle (PubMed:20393707, PubMed:22183084, PubMed:25910960, PubMed:33387709).  Shows esterase activity towards p-nitrophenol-linked aliphatic esters (pNP-aliphatic esters) (PubMed:20393707, PubMed:22183084, PubMed:25910960, PubMed:33387709).  Capable of degrading the plastic poly(ethylene terephthalate) (PET), the most abundant polyester plastic in the world (By similarity).  Can also depolymerize the synthetic polyesters poly(epsilon-caprolactone) (PCL), poly(butylene succinate-co-adipate) (PBSA), poly(butylene succinate) (PBS), and poly(lactic acid) (PLA) (PubMed:20393707, PubMed:22183084).
What are the official names of this protein?
Cutinase est2, Poly(ethylene terephthalate) hydrolase, PET hydrolase, PETase, TaCut2.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Secreted. Periplasm.
Protein: RAD9B_RAT
Sequence: MTGGQVKVFGKAIQTLSRVSDELWLDPSEKGLALRSVNSCHSTYGYVLFSSVFFQHYQWSPSATITDSDIPLNLNCKLAIKSILPIFRCLNYLERSIEKCTMVARSDRCRVVIQFFGRHGIKRTHNVYFQDCQPLKILFEKSLCANILMIKPRLLAEAIALLTSNQEEVTFSVTPENFCLKSSSGESLDLTSSVYSEMSFGPEEFDFFQVGLDTEITFCFKELKGILTFSEVMHAPIAIYFDFPGKPVVLSVEDMLLEASFILATLLDYPSRTSSPQSLRLSQARRSDPTLSGAQEGKSRVSQTPESISRAAPKRLFPKDPPDSSSAAETRRASASQDDISEVPESVVSDMEEGQSPSPLRKFSCMFFGAVSCEQQEHANHPLGSLAVASDSEQDASG
What are the official names of this protein?
Cell cycle checkpoint control protein RAD9B, DNA repair exonuclease rad9 homolog B.
What is the protein family that this protein belongs to?
Belongs to the rad9 family.
Protein: IPA9_SHIB3
Sequence: MLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPQALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFKDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQLIYRQLTDEVLALRLSENGSQLHHS
What is the function of this protein?
Effector E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell.  Interacts with IKBKG (NEMO) and TNIP1 (ABIN-1), a ubiquitin-binding adapter protein, which results in TNIP1-dependent 'Lys-27'-linked polyubiquitination of IKBKG.  Consequently, polyubiquitinated IKBKG undergoes proteasome-dependent degradation, which perturbs NF-kappa-B activation during bacterial infection.  Mediates polyubiquitination of host U2AF1, leading to its proteasomal degradation.  Catalyzes 'Lys-48'-linked polyubiquitination and subsequent degradation of a subset of host guanylate-binding proteins (GBP1, GBP2, GBP4 and GBP6), thereby suppressing host cell defense.  In contrast, host GBP3 and GBP7 are not ubiquitinated by IpaH9. 8.  Uses UBE2D2 (UBCH5B) as an E2 ubiquitin-conjugating enzyme.
What are the official names of this protein?
E3 ubiquitin-protein ligase ipaH9.8, Invasion plasmid antigen ipaH9.8.
What is the protein family that this protein belongs to?
Belongs to the LRR-containing bacterial E3 ligase family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus. Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm. Transported into the host nucleus (By similarity).
Protein: RIFN_AMYMS
Sequence: MGTPYHLGIDVGGTKVAFRVESGSACIEETSFSWGARHSAEDDLAQLAGHVARLRERIGTPLEAVGVAMPGTVGADGRVATWPSRPEWTGVDLKTALHSLFPEAAVAWADDGDLGALAESRASGCENLLYIGIGTGIGGGLVLGGVPCPGLGRGSFEIGHVIVEMGGVRCVCGRRGCLQALASGPATLRRASLLRGADVTYYRLQRALRNGEPWAADALEGSTRALAAAVTGVQELVHPDRVLIGGGFAAGIPEIVPSVSGFLADLVRQGQAPLPVEPAALGGLSSLRGAVALAGLVAAGEVP
What is the function of this protein?
Involved in the biosynthesis of 3-amino-5-hydroxybenzoate (AHBA), a compound that then serves as the starter unit for the assembly of a polyketide during the biosynthesis of rifamycin B and other ansamycin antibiotics.  Catalyzes only the phosphorylation of kanosamine to yield kanosamine 6-phosphate.
What are the official names of this protein?
Kanosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
Protein: LRCL1_HUMAN
Sequence: MAGPGWTLLLLLLLLLLLGSMAGYGPQKKLNLSHKGIGEPCRRHEECQSNCCTINSLAPHTLCTPKTIFLQCLPWRKPNGYRCSHDSECQSSCCVRNNSPQELCTPQSVFLQCVPWRKPNGDFCSSHQECHSQCCIQLREYSPFRCIPRTGILAQCLPL
What are the official names of this protein?
Leucine-rich colipase-like protein 1.
Protein: MVB12_YEAST
Sequence: MNNNVEELLRRIPLYNKYGKDFPQETVTRFQMPEFKLPALQPTRDLLCPWYEECDNITKVCQLHDSSNKKFDQWYKEQYLSKKPPGIVGNTLLSPSRKDNS
What is the function of this protein?
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.  Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs).  Appears to be involved in cargo sorting and release of the ESCRT-I complex from the MVBs.
What are the official names of this protein?
Multivesicular body sorting factor 12, 12 kDa multivesicular body sorting factor, ESCRT-I complex subunit MVB12.
What are the subcellular locations of this protein?
Cytoplasm. Endosome. Late endosome membrane; Peripheral membrane protein.
Protein: PSBT_LACFR
Sequence: MEALVYTFLLVSTLGIIFFAIFFREPPRISTKKMK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: VP2_ROT41
Sequence: MAYRKRGARREANVNNNDRMQEKDVEKQDQNSKTQLSDKVLSKKEEIITDNQEEVKIADEVKKSTKEESKQLLEVLKTKEEHQKEIQYEILQKTIPTFEPKESILKKLEDIKPEQAKKQTKLFRIFEPRQLPIYRANGEKELRNRWYWKLKKDTLPDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVVDSETASICDAIFQDEETEGAVRRFIAEMRQRVQADRNVVNYPSILHPIDYAFNEYFLQHQLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIVNTIVYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRNGHVINQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKMKAIVEDFLKRLHIFDVARVPDDQMYRLRDRLRLLPVEVRRLDIFNLILMNMDQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQPVALVGALPFITDSSVISLIAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVPTSTTKVYKQVPQQFDFRNSMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL
What is the function of this protein?
Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices.  This capsid constitutes the innermost concentric layer of the viral mature particle.  It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini.  VP2 is required for the replicase activity of VP1 polymerase.  Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles.  May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication.
What are the official names of this protein?
Inner capsid protein VP2.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP2 family.
What are the subcellular locations of this protein?
Virion. Note=Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: 3NO2D_NAJHA
Sequence: LTCFNCPEVYCNRFHTCRNGEKICFKRFNERKLLGKRYTRGCAATCPVAKPREIVECCSTDRCNH
What is the function of this protein?
Binds with low affinity to muscular (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and very low affinity to neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR).
What are the official names of this protein?
Weak toxin CM-13b.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Ancestral subfamily. Orphan group II sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: REX_STRP4
Sequence: MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLHYRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSVKSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_DEBHA
Sequence: MSLSNKLSVKDLDVSGKRVFIRVDFNVPLDGKTITNNQRIVAALPTIKYVLENKPKAVILASHLGRPNGEKVDKFSLAPVASELEKLLGKKVNFLDDCVGDNVEKAVNGGSDGEVFLLENLRFHIEEEGSQKKDGEKVKASGEDVKKFRQQLTNLADVYVNDAFGTAHRAHSSMVGLELPQKAAGFLMAKELEYFAKALENPVRPFLAILGGAKVSDKIQLIDNLLDKVDLLIVGGGMSFTFKKVLDNMPIGDSLFDEAGAKNVENLVAKAKKNNVKIVLPVDFITADKFDKDAKTSTATEDEGIPDNWMGLDAGPKSNELFAKTVAEAKTIVWNGPPGVFEFDNFAKGTKSLLDAAVKSAESGNTVIIGGGDTATVAKKYGVVDKLSHVSTGGGASLELLEGKELPGVVAISDKK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEP_I69A0
Sequence: MDSNTVSSFQDILLRMSKMRLGSSSEDLNGMITQFESLKIYRDSLGEAVMRMGDIHSLQNRNGKWREQLGQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLFEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RNT_YERP3
Sequence: MADKSDLNALSGRFRGYYPVVIDVETAGFNAQSDALLEIAAVTLQMNKEGWLLPDETLHFHVEPFEGANLQPEALAFNGIDPTNPLRGAVSEHDALHAIFKAVRKGIKDKGCNRAIIVAHNANFDHSFVMAAAERASLKRNPFHPFATFDTAALSGLVLGQTVLAKACLAAGIPFDSSQAHSALYDTLQTAKLFCELVNRWKKLGGWPLPAAESE
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: MTND_MONDO
Sequence: MVEAWYMDDSEEDQRRPHRLEPERPVSLAHLQQLGVFYWKLDADKYEDDPELEKIRKERKYCWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDKWIRIFMEKGDMITLPAGIYHRFTLDETNYVKAMRLFVGEPVWTAYNRPADHFEIRGQYLQFLAQKG
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.  Also down-regulates cell migration mediated by MMP14.
What are the official names of this protein?
Acireductone dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD, Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1, MTCBP-1.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
Protein: PYRD_BURP6
Sequence: MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLACALSPRVPDAPRTVMGLSFRNPVGLAAGLDKDGAAIDGFAALGFGFIEVGTVTPRAQPGNPRPRLFRLPEADAIINRMGFNNSGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQRRLADLHGKLVPLALKIAPDLDDEQVKEIAATLLRHDIEGVIATNTTLSREAVKGLPHADEAGGLSGRPVFDASNAVIRKLRAELGDAVPIIGVGGIFSGEDARAKLAAGAALVQLYTGFIYRGPALVAECVKAIARG
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RISB_ALIF1
Sequence: MNVIEGGVAAPNAKIAIVISRFNSFINESLLSGAIDTLKRFGQVSEENITVVRCPGAVELPLVAQRVAKTAKYDAIVSLGSVIRGGTPHFDYVCSECNKGLAQVSLEYSIPVAFGVLTVDTIDQAIERAGTKAGNKGAEAALSALEMINVLSQIES
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: MRM3_DROME
Sequence: MLCNIFKRSLQANIRNVNNLNVLRLSSSSGPRGEIQDALDIEANLFGNSDLRHEPMNTREALRKNRFAGRKPKVPFASVASRNLSAPSNPAPRVAPTPAPVIKDNELNLEFVRLTLQDPLTSTLLTTVRSRKRRDKNRQIIVEGRRLIQEALQCGLKMEVLLFSQKDQLALVKEEVGVAQVETGTKIYKVPQHDLKTWSSLVTPPGLMAIFDRPSDKGLEKNLAEQQRLGSQPFPITVVCDNIREPNNLGSIIRTCAALPCSQVVVTHGCCDPWESKALRGGCGGQFRVPIRDDVTWDELALTIPPEAADDCHVFIAETNQRKRENNQTIDYADIKGLGAHNLLIIGGESHGVSEEAYRFLNLVGGKGKCIYIPLAAGIDSLNVASALTLLLFELRRKLIHQASEKE
What is the function of this protein?
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1580 (Gm1580) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
What are the official names of this protein?
rRNA methyltransferase 3, mitochondrial, RNA methyltransferase-like protein 1, rRNA (guanosine-2'-O)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MURC_LARHH
Sequence: MKHKVRHIHFVGIGGVGMSGIAEVLLTLGYTVSGSDLAASATTERLAAAGAQIHVGHAEGHVHGANVVVTSTAVQADNPEVMAARAAGIPIVPRAQMLAELMRFKQGIAIAGTHGKTTTTSLVASALGRAGLDPTFVIGGRLTAAGSNARLGSGDYLVAEADESDASFLCLSPVMAVVTNIDADHMDTYGHDFERLKQAFIDFLQRLPFYGRAVLCIDDKHVREILPFVTRPLTTYGLTPDADVRADNIRPVAGQMLFDVVWQQQGEEQRHPVTLNLPGRHNVLNALAAIAIGLECGADIGAIAAGLTEFSGVGRRFQRYGDIALPAGGQATVVDDYGHHPVEMAATLAAARGAFPERRLVLAFQPHRYTRTRDLFEDFVGVLSTVDALLLAEVYPAGEAPIVAADGRALARAVRVAGKVEPVFVERIADLPATLLDQLQDGDVVLTMGAGSIGQTPGRLVTLAGTQAA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISLA_OLEA2
Sequence: MQCCTTPLSPHEQRLQDKIAGKEDSFRKSHERVFNILDSFDGKRPRIDVERAKLFTDSMKETEGQPLVLRWAKAMKHVAEHITVYIDDDQLICGRGGCPGRYGVLYPELDGDFLDLAIEDLPNRTESPFTITEADARVVVEEIAPYWKGKTYHEDLNLALPSDVHKLTYDDPQGLKSRFIVNETSSFRSSIQWVHDYEKVLKRGFRGLKEEAQEKIAGLDPLSPRDNVEKRPFLEAIVIVCDAIILWANRHAKLAADMAAAETNPVRKAELETMAEICAWVPENPARNFYEAVQAQWFTQMFSRLEQKTGTIVSNGRMDQYFWPFYRKDIEEGRITEESALELLECMWVGMAQYVDLYISPAGGAFNEGYAHWEAVTIGGQTPQGLDATNDLTYLFLKSKREFPLHYPDLAARIHSRSPERYLHDVAETIKFGSGFPKLINDEEIVPLYVSKGASFEEALDYAVSGCTEARMPNRDTYTSGGAYINFAAALEMVLYNGRMLKYGENELGLETGDPTRFETWEEFWNAYVLQHEHFLRAAFIQQHIINNVRARHFAQPMGSALHDLCMKHCLDLHTPQIPEGINLGYFEYMGFGTVVDSLAAIKKLVFEDKKLTMQEVIEALKCNFEGKEDVQQMLKSAPCYGNNDEYADSIAREIDAISVKYGRRYSPELGMHNDVRYVPFTSHVPFGKVVSATPNGRLAWTPLSDGSSASHGADVNGPTAVLQSNFSSKNYGYRDRAARMLNIKFTPKCVEGDEGTEKLVSFIRTFCDLKLWHVQFNVINRDTLIAAQKDPEKYRSLIVRIAGYSAYFVDLSPDLQNDLIARTQHDAM
What is the function of this protein?
Involved in an anaerobic respiration pathway that converts the sulfonate isethionate (2-hydroxyethanesulfonate) to ammonia, acetate and sulfide.  Catalyzes the radical-mediated C-S bond cleavage of isethionate (2-hydroxyethanesulfonate) to form sulfite and acetaldehyde.
What are the official names of this protein?
Isethionate sulfite-lyase, Glycyl radical enzyme IslA, GRE IslA.
What is the protein family that this protein belongs to?
Belongs to the glycyl radical enzyme (GRE) family.
Protein: AROK_PYRAB
Sequence: MRGSGRASSAITIVNAFATGKGAAIGIELWTEARVRVTGDGEVRGKIVVKGEEFKDYRLVNSVISVLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLNIDDLSIVKLGVEAAKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPETVVLLIPRETVLTESLKGVDFSKISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGAFVGLCGKGPAFFAIADEPEEIIEAWSSFGDVIATSLR
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN625_HUMAN
Sequence: MGERLLESKKDHQHGEILTQVPDDMLKKKTPRVKSCGEVSVGHASLNRHHRADTGHKPYEYQEYGQKPYKCTYCKKAFSDLPYFRTHEWAHTGGKPYDCEECGKSFISRSSIRRHRIMHSGDGPYKCNFCGKALMCLSLYLIHKRTHTGEKPYECKQCGKAFSHSGSLRIHERTHTGEKPYECSECGKAFHSSTCLHAHKITHTGEKPYECKQCGKAFVSFNSVRYHERTHTGEKPYECKQCGKAFRSASHLRTHGRTHTGEKPYECKQCGKAFGCASSVKIHERTHTGEKPCSSNTSKGQGEKIA
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 625.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TTLL1_RAT
Sequence: MAGRVKWVTDIEKSVLINNFEKRGWVQVTENEDWNFYWMSVQTIRNVFSVETGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAEKDENGKYLYLDFVPVTYMLPADYNLFVEEFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSTKEAYVISLYINNPLLIGGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGGKWTVNNLRLYLESTRGREVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGAERELRSRPGQPVGPRTGRSRDSGRNVLTTWK
What is the function of this protein?
Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin.  Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step.  Modifies both alpha- and beta-tubulins with a preference for the alpha-tail.  Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity.  Part of the neuronal tubulin polyglutamylase complex.  Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility.  Involved in respiratory motile cilia function through the regulation of beating asymmetry.  Essential for sperm flagella biogenesis, motility and male fertility.  Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
What are the official names of this protein?
Polyglutamylase complex subunit TTLL1, Tubulin polyglutamylase TTLL1, Tubulin polyglutamylase complex subunit 3, PGs3, Tubulin--tyrosine ligase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the tubulin polyglutamylase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum.