PharMolix/UniProtQA huggingface dataset:
Protein: PYRI_METB6
Sequence: MRHIAAADTGDDEGEGLLVRRIKNGTVIDHIDGGEALNVIRILGISGTTNEALSIATNVPSKHMGSTKDIVKISNRELSKEEVDRIALISPNATINIIRHFKVCEKQGVEIPTVIEGSVRCPNPGCITRTNEPIRTRFAVLPDGKGLRCLYCDSVITKDLTSYII
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: REPI1_BOVIN
Sequence: MLERRCRGPVAMGPAQPRLLSGPSQESPQTLEKEPQGLRSRGTAAAQSGGQALGRAHRCAHCRRHFPGWVALWLHARRCQARLPRPCPECGRRFRHAPFLALHCQVHAAATPDQGFACHLCGQSFRGWVALVLHLRAHSAAKRPIACPACERRFWRRKQLRAHSRRCHPPAPEARPFICGNCGRSFAQWDQLVTHKRVHVAEALEEAAAKALGPRPRGRPAVTAPRPGGDAVDRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCTECGRRFRHKPNLLSHSKIHKRSEGSAQGGPQPPASAPERTPEPPPEPAPEPAEVPVGPGQPSAAAEAPPSLHTCADCGRGFRLERFLRAHQRQHGGERPFACAECGKHFGKKTHLVAHSRVHSGERPFACEECGRRFSQGSHLAAHRRDHAPERPFVCPDCGKAFRHKPYLAAHRRIHTGEKPYVCPECGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKSNLITHRKSHIRDGAFCCAICGQTFDDEGKLLAHQKKHDV
What is the function of this protein?
Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication.  Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone.  Facilitates DNA bending (By similarity).
What are the official names of this protein?
Replication initiator 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: HDFR_YERPB
Sequence: MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGANLFTRHRNNIRLTPAGERLVPYAEMLLNTWRLAKKEVIHSLQHTELSIGATASLWEAYLTPWLQQLYEQQEELRLEARIALRNSLVKQLHERQLDLLITTEPPKMDELACLLLGHFSLRLYSSFSLDLPKEDDTPNEHKNASEVPYIKLEWGADFHQQENRLLDSEQAPILTTTSAHLTRQLLETTGGCAFLPEHWQKEYPQLVIHPDIPPIVRPLYAVWLQNSDQQALIRQLLKTPMNNATQSVTRE
What is the function of this protein?
Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
What are the official names of this protein?
HTH-type transcriptional regulator HdfR, H-NS-dependent flhDC regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: RM24_SCHPO
Sequence: MASKLLRKLAYPTLPVKGKIYDPFSKFQQNLYGGSKTEAGNNKIPKFGHKTRRVWIPNGHSKWLYSNVLEEKFHLYVTSRVLRTIDKEGGLDEYLVKSTPSRLKSLGLRGVELRALVLHKLGAKNPILEKLPSDSGAQKRYLEKVKDVVLKLNRSKKLYQQIKSLVGKERSVNTSV
What are the official names of this protein?
54S ribosomal protein L24, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: EFHD2_HUMAN
Sequence: MATDELATKLSRRLQMEGEGGGETPEQPGLNGAAAAAAGAPDEAAEALGSADCELSAKLLRRADLNQGIGEPQSPSRRVFNPYTEFKEFSRKQIKDMEKMFKQYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKNMIKEVDEDFDSKLSFREFLLIFRKAAAGELQEDSGLCVLARLSEIDVSSEGVKGAKSFFEAKVQAINVSSRFEEEIKAEQEERKKQAEEMKQRKAAFKELQSTFK
What is the function of this protein?
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis.  Plays a role as negative regulator of the canonical NF-kappa-B-activating branch.  Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
What are the official names of this protein?
EF-hand domain-containing protein D2, Swiprosin-1.
What are the subcellular locations of this protein?
Membrane raft. Note=In a mouse immature B-cell line WEHI-231.
Protein: LEUD_NEIM0
Sequence: MKAFTKITAIVAPLDRSNVDTDAIIPKQFLKSIKRSGFGPNAFDEWRYLDHGEPGMDNSKRPLNPDFSLNQPRYQGAQILLTRKNFGCGSSREHAPWALDDYGFRAVIAPSFADIFFNNCYKNGLLPIVLTEEQVDRLFKEVEANEGYQLSIDLAEQTLTTPSGETFTFDITEHRKHCLLNGLDEIGLTLQHADEIHAFEEKRRQSQPWLFNG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: TIM14_YARLI
Sequence: MSTTPVQPLQSEPLMDSETGVAPQIEAPQVPEGPKKGIDEQIFDYFAEHPVQATAATLVGLYALGAVFKRPAAGARGQFFKGGFENKMGPSEALQILSLRDAGLTMNKLKGQHRKIMLLNHPDRGGSPYVATKINEAKSVLEKRGGLK
What is the function of this protein?
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM14, Presequence translocated-associated motor subunit PAM18.
What is the protein family that this protein belongs to?
Belongs to the TIM14 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: SL9C1_HUMAN
Sequence: MAGIFKEFFFSTEDLPEVILTLSLISSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFTSSQVQRYANAIQWMSPDLFFRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYILVLWHLASVNQLLLKPTQWLLFSAILVSSDPMLTAAAIRDLGLSRSLISLINGESLMTSVISLITFTSIMDFDQRLQSKRNHTLAEEIVGGICSYIIASFLFGILSSKLIQFWMSTVFGDDVNHISLIFSILYLIFYICELVGMSGIFTLAIVGLLLNSTSFKAAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVGHEFSWRWIFIMVCSEMKGMPNINMALLLAYSDLYFGSDKEKSQILFHGVLVCLITLVVNRFILPVAVTILGLRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDLANADWNMIEKAITLENPYMLNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANRRLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGPSKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAITLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMSHQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILKAFGLKGIISKTEGAGINKLIMAKKKEVLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKVVTFDCGNDIFEEGDEPKGIYIIISGMVKLEKSKPGLGIDQMVESKEKDFPIIDTDYMLSGEIIGEINCLTNEPMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKMWLKLGLAITARKIREHLSYEDWNYNMQLKLSNIYVVDIPMSTKTDIYDENLIYVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVIIQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTLEEGIQEERNVKEDGAHSAATARSPQPCSLLGTKFNCKESPRINLRKVRKE
What is the function of this protein?
Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa.  Required for sperm motility and fertility.  Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization.  Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity).
What are the official names of this protein?
Sodium/hydrogen exchanger 10, Na(+)/H(+) exchanger 10, NHE-10, Solute carrier family 9 member 10, Solute carrier family 9 member C1, Sperm-specific Na(+)/H(+) exchanger, sNHE.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Protein: WHIA_DESAP
Sequence: MSFSAHTKDELARIEGLPSCCRLAELAALAKLNGRLVHGPAELLIVTENAAIARKVFKALKMQFRLAARVEIRRKPRLKKNNEYLVRIGNQDGLGPALEEMGLCTVSLRVRPGLKRDLVRRECCRRSYLRGAFLARGSVSSPRGSYHLEITVGDQRMAADLSGLMRKVGLEGRLSPRKRGWIVYLKDGEQVADALKLMGAHAALLDFENARVYKDMRNRVNRLVNCDTANLGKTVSAGVRQEEHIRLVVQRFGLETLSPPLRQVARLRLQYPEVSLRELGELAQPPLSKSCVNHRLRKLEQIAEHILASRTRN
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: ANO2_MOUSE
Sequence: MAAPGLRDIPLLPGSPRRLSSRTVARGSQGPKHGQQYLKVPGHRAPGQRDNSSLHPSQVSRRESSRDRSVINNYLDANEPPSSEARLSRMHFHDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDVELGPLDALEEERREQRDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAILQTLSSPLQPRVPEHSNNRMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPGDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSKEMCDHQNAFTMCPLCDKSCDYWNLSSACGTARASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERSQEHSRPEYETKVREKLLKESGKSAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEPGESDPDHSKRPEQWDLDHSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVLSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKVKLADEPTQRSQGGGDRSRRSRAASSAPSGRSQPGSIASSGSQHTNV
What is the function of this protein?
Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction.  Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process.  May mediate light perception amplification in retina.
What are the official names of this protein?
Anoctamin-2, Transmembrane protein 16B.
What is the protein family that this protein belongs to?
Belongs to the anoctamin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NU6M_NEUCR
Sequence: MNSLFLINESFTNGYISSVLDIISILAIFCGISVIVNKNPIISVLFLIGLFASVSSYLILLGLSFIGLAYLIVYIGAISILFLFILMLINIRISELQSNTNNSIPLTIILGISLSYSLFQLLPYDIAILSNFSSNINNNLYNLSMNKQNNGNFGINTTPAVSLQPKNNDLLFVTSKIWDGNLAESNHITTIGNVMYSNYSIWLFLASFILLLAMVGSIVIIMKSNASWGGALPNTRETKTEGR
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: EFPL_ALIF1
Sequence: MPKASDIKKGSAIEHNGKVFFVKEISKLTPSGRAGATLFRMRMYDVATGAKSDESFKADDMINLADFSRRSATFSYVDGNEYVFMDSEDYTPYNFNKEAIEEELLFITEETQGLQILIVDGAPVAIELPSAVDLEIVETAPSIKGASASARTKPATMTTGLTVQVPEYIANGEKVKINTTEHKFMSRA
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: OBG_ALKEH
Sequence: MKFVDEVTIRVEGGDGGDGCASFRREKYIPRGGPDGGDGGHGGSVWLRADEGLNTLADFRHERKFTAQRGENGMGKQRYGKSGQDREIAVPVGTLVSDADTGELIGELLEHGQRLLVARGGKGGLGNVHFKSSTNRAPRQYTPGTKADRRNLHLELRLLADVGLLGMPNAGKSTLVRAISSARPRVADYPFTTLYPNLGVVSVGAARSFVVADIPGLIEGAAEGAGLGIQFLKHLGRTRLVLHVIDAVPLDPAQDPVDDARKIVAELGRYSESLAARERWLVLNKLDLLPEEDRDAHVNDLLQRLQWGGPVYRISALSGDGTRQLAQDVMNRLEVMDEEAREAGERARREQRQEEGPE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_CLOBB
Sequence: MGKKYIESSKLIDKSALYNSTEALDLTVKTAKANFDETIELHVRLGVDPRHADQQVRGAVVLPNGTGKTVRVLVFAKGDKATEAQEAGADFVGAEDLVQKIQSENWFDYDVVVATPDMMGVVGRIGRVLGPKGLMPNPKSGTVTFDVAKAIAEIKAGKVEYRVDKTSIVHCPIGKKSFGTEKLKENFTTLMEALVKAKPAAAKGQYLKSITVSSTMGPGAKINPTKALD
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: NADA_EHRCR
Sequence: MKELDVITLLQEIRHLAQESNAVILAHYYQDSEIQDIADFIGDSLELSRKAATTTADVIVFCGVYFMAEVAKIINPAKKVLLPDLNAGCSLADSCDAESFKKFRELHKDCVSITYINSLAEVKAYSDIICTSSSAEKIIRQIPEEKQILFAPDKFLGAFLEKKTNRKMILWPGTCIVHESFSERELIDMMVRHDKAYVLAHPECPGHLLKYAHFIGSTTQLLKFSSDNPNSEFIVLTEEGIIHQMKKVSSGSTFYIVKTSDSGGCVSCSKCPHMRLNTLEKLYLCLKNGYPEITLDPEISSMAKRSLDAMLKMS
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_ALKMQ
Sequence: MAKKVVGQIKLQIPAGKATPAPPVGPALGQHGVNIMGFCKEFNAKTADQAGMIIPVIISVYQDRSYTFITKTPPAAILIKKAAGIDKASGEPHTKKVATISKAKVKEIAELKMPDLNASSVESAMSMIAGTARSMGVVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SECD_SHIFL
Sequence: MLNRYPLWKYVMLIVVIVIGLLYALPNLFGEDPAVQITGARGVAASEQTLIQVQKTLQEEKITAKSVALEEGAILARFDSTDTQLRAREALMGVMGDKYVVALNLAPATPRWLAAIHAEPMKLGLDLRGGVHFLMEVDMDTALGKLQEQNIDSLRSDLREKGIPYTTVRKENNYGLSITFRDAKARDEAIAYLSKRHPDLVISSQGSNQLRAVMSDARLSEAREYAVQQNINILRNRVNQLGVAEPVVQRQGADRIVVELPGIQDTARAKEILGATATLEFRLVNTNVDQAAAASGRVPGDSEVKQTREGQPVVLYKRVILTGDHITDSTSSQDEYNQPQVNISLDSAGGNIMSNFTKDNIGKPMATLFVEYKDSGKKDANGRAVLVKQEEVINIANIQSRLGNSFRITGINNPNEARQLSLLLRAGALIAPIQIVEERTIGPTLGMQNIEQGLEACLAGLLVSILFMIIFYKKFGLIATSALIANLILIVGIMSLLPGATLSMPGIAGIVLTLAVAVDANVLINERIKEELSNGRTVQQAIDEGYRGAFSSIFDANITTLIKVIILYAVGTGAIKGFAITTGIGVATSMFTAIVGTRAIVNLLYGGKRVKKLSI
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACP_METFK
Sequence: MSDIEQRVKKIVSEQLGANEADVKNESSFVDDLGADSLDTVELVMALEEEFDCEIPDEEAEKITTVQQAIDYVNANLK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRE5_YEAST
Sequence: MGVTVQDICFAFLQNYYERMRTDPSKLAYFYASTAELTHTNYQSKSTNEKDDVLPTVKVTGRENINKFFSRNDAKVRSLKLKLDTIDFQYTGHLHKSILIMATGEMFWTGTPVYKFCQTFILLPSSNGSTFDITNDIIRFISNSFKPYVLTDASLSQSNEENSVSAVEEDKIRHESGVEKEKEKEKSPEISKPKAKKETVKDTTAPTESSTQEKPIVDHSQPRAIPVTKESKIHTETVPSSTKGNHKQDEVSTEELGNVTKLNEKSHKAEKKAAPIKTKEGSVEAINAVNNSSLPNGKEVSDEKPVPGGVKEAETEIKPIEPQVSDAKESGNNASTPSSSPEPVANPPKMTWASKLMNENSDRISKNNTTVEYIRPETLPKKPTERKFEMGNRRDNASANSKNKKKPVFSTVNKDGFYPIYIRGTNGLREEKLRSALEKEFGKVMRITAADNFAVVDFETQKSQIDALEKKKKSIDGIEVCLERKTVKKPTSNNPPGIFTNGTRSHRKQPLKRKD
What is the function of this protein?
Has a role in de-ubiquitination.  In conjunction with UBP3, cleaves ubiquitin, leading to the subsequent mono-ubiquitination of sec23.
What are the official names of this protein?
UBP3-associated protein BRE5, Brefeldin-A sensitivity protein 5.
Protein: ISY1_YARLI
Sequence: MSRNSEKQGSMLHRFQQQQANAAGLLDVGRTVRPTYISGVESLPQAEKWRSQVMKEISRKVTKIQDPALSDFQLRDLNDEINKLMSERHRWDLQIRSLGGPNYASFGGKKRGYQYYGRARELPGVSEMLQSQKKDDTKKSGDFYIPPKNLNMVYFGYADDNVTGLMEFEKQRESELQDMLAGKPDEDSGFVVGDITVPEEGDLEARLLEERKRRVQALLD
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor ISY1.
What is the protein family that this protein belongs to?
Belongs to the ISY1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: T2F1_HAEIF
Sequence: MNDEISDLINQAVSNILINSSSENKLKKLIKTHDVKIHFVPRNYRIFGGILQSMNIQFGNFLEEFMTLLIKSDGRYDILEEYSGKKSNKFQLSTSNDNRIDQFISFCQRSDSINLDEEFPKLLNEVKNDNDTNLSSISHDIDILFRNKETGVIYYLEVKYNDDHDTGKFVDINRKFIKTYAYLVREFPNTEIKPILFFFNNKKMKGNIYVPENTNIRRGKSFFDEFLKIKYEDVDSYIRNLSESPDNIKAFDDLYRKIMAMK
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GANTC-3' and cleaves after G-1.
What are the official names of this protein?
Type II restriction enzyme HinfI, R.HinfI, Endonuclease HinfI, Type-2 restriction enzyme HinfI.
Protein: TRMN6_SHIFL
Sequence: MSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTSDSVIIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQQTVRFDLIISNPPYYQQGVECATPQREQARYTTTLDHPSLLTCAAECITEEGFFCVVLPEQIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYSEAYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_ESCF3
Sequence: MKRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYGQRHRAEIDVARELALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPEADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVSLGMAKDIRFETPLMWIDKAETWALADYYGKLDLVRNETLTCYNGIKGDGCGHCAACNLRSNGLHHYLADKPTVMAAMKQKTGLK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: DUT_ACIAD
Sequence: MKVQVKILDQRLGQEWPLPSYATTGSAGLDLRACLDEAIQIEPGQTVLIKTGMAIYIHDTNFAGLILPRSGLGHKHGIVLGNLVGLIDSDYQGELMISVWNRGQNTFTLEPGERLAQYVLVPVIQAEFEQVEEFVATDRGAGGFGHTGQK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: SEY1_ASHGO
Sequence: MSEDGASKCQDSIQLIDEQKQFNEKTLEYFKRCIGERDVGLDYHVISVFGSQSSGKSTLLNALFNTKFDTMNAQVKRQQTTKGIWIAHTREVQTTANTGKGVDFFVLDVEGSDGAERGEDKDFERKAALFALATSEVLIVNMWEQQVGLYQGNNMGLLKTVFEVNLSLFGHKKDKQKILLLFVVRDFTGFTPLSSLQETLTNELQAMWSELNKPAGAEGSSLDDFFDFAFTGLSHKLFKPEEFASDVAKLGDKFTDLKREDYYLSGKYHQGLPLDGWSFYADSCWEQIENNKDLDLPTQQTLVANFKTEEIANNAFEHFSTAFSKLSSSLPGPELAASMKELKDQCTKEYDNYGSRYMKAVYLEKRGELLDKIKTKFSDAIAVHMSKLFNSLVSTFQSTVAQNAACQPLSERLKVGKERVMQVFEQETSDFVALELIPSVDADASALLEKIDELAERERGKEMKAIILRAKKYQFTHTRDDIVHLLSHPQDNVWQLVMDHFDDVFRRSVLKYKLPNLGDVTDESTAYDFQLDLIEEDNYALYLKIRSNAWTILYDIIHQYLKEDNVVSILRERFESKFRYDQNDVPRLWKNEEEVDAGFKVAREHALNMLNTLSIASCDGVEIVPDVPLASDEDEAQDEQGLYNEKRFGHILTAIQKEKIIQHFKRFANVAVVEAKRSTIKSHTHIPMWIYAIIAVLGWNEFMLVLRNPLFIALMLLIVGAAYTVHRLNLWTPLATFASAAVNETTHAVKAKLRTILLDDEHPKNASSKPVESFEMQDLSVNETKENANES
What is the function of this protein?
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein SEY1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: GLGA_THEMA
Sequence: MKVVFVSYEVFPFAKVGGLADVAGTLPKYLKKHGVDVTIVMPKHRIVEKNAEKFGYEIKKVAESLSVSHVKTDQKFDIYESVLPGSDVKTYFVANDYYFSAEDVYAGPDLGEQAIFFCAATLDLVKHLDLKPDIVHVNDWQTALIPVYLKTVYRDDPYFSRTATVLTIHNLGYQGVFDPKYLSFAGLPDYVYTIDGLEFYGQLNFLKGGIVFSDVINTVSPTYAEEIQTEEYGEKLDGVLRMRSKDLYGILNGIDYELYNPATDRYIYVNYDVNRLELKWENKVKLQEELGLPVNKETAVAGLISRLVPQKGLDLLVDVMDYLTLFDLQIVVLGTGDEQYENAFRKFQERYPDKVSANIKFDVELAQKIYAGADIFLMPSRYEPCGLGQMFSMRYGTIPVVRYTGGLADTVKEYDPQSMEGTGFGFKKYDSAHLLKAVSKALHFYYREKDHWRRIMTNAMNTDLSWDRSAKEYVDLYKKALAKVGR
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: TBC15_MOUSE
Sequence: MAAAGVVSGKIIYEQEGVYIHSSCGKANDQDSLISGILRVLEKDAEVIVDWRPLDDALDSSSILCAGKDSSSVVEWTQAPKERAHRGSDQQSSYEAEWDMVTTVSFKKKPHTNGDAPGHRNGKSKWSFLFSLADLKSVKQSKEGMGWSYLVFCLKDDVMLPALHFHQGDSKLLIESLEKYVVLCESPQDSRTLLVNCQNKSLSQSFENLLDEPAYGLIQKIKKDPYTATMVGFSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWNKSLDPEGRLVAVESMKQKIFRGGLSHSLRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSVSEAQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCKNFHLLLCCAILESEKQQIMAKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMAQCKELPQAVCEILGLQDSEITTPDSDTDENVGSPCPVSAFPSSTLPILAASEAKDDSPTQTLASPNACRLTPA
What is the function of this protein?
Acts as a GTPase activating protein for RAB7A.  Does not act on RAB4, RAB5 or RAB6.
What are the official names of this protein?
TBC1 domain family member 15, GTPase-activating protein RAB7, GAP for RAB7, Rab7-GAP.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COLI_HUMAN
Sequence: MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE
What is the function of this protein?
Endogenous opiate.
What are the official names of this protein?
Pro-opiomelanocortin, POMC, Corticotropin-lipotropin.
What is the protein family that this protein belongs to?
Belongs to the POMC family.
What are the subcellular locations of this protein?
Secreted. Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.