PharMolix/UniProtQA huggingface dataset:
Protein: NANA_STAHJ
Sequence: MEDKLKGLYAALLVPFDEHGQVKEEGLKQIAKNAIETEKLDGLYVNGSSGENFLISKEQKKQIFRVVKETVGDDVNLIAQIGSLDLNEAIELGKYATELGYDALSAVTPFYYPFSFEEIKQYYFDIIEATQNNMIIYAIPDLTGVNISIEQFGELFNHEKVVGVKYTAPNFFLLERIRKAFPNKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARQIFDLAREGKIAEAYQIQHDTNDIIETVLSMGIYPTLKEILKSRGIDGGLPKRPFRPFDESHRDALDTLIKKYDL
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_ECODH
Sequence: MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMJ_SHIB3
Sequence: MKICLIDETGAGDGALSVLAARWGLEHDEDNLMALVLTPEHLELRKRDEPKLGGIFVDFVGGAMAHRRKFGGGRGEAVAKAVGIKGDYLPDVVDATAGLGRDAFVLASVGCRVRMLERNPVVAALLDDGLARGYADAEIGGWLQERLQLIHASSLTALTDITPRPQVVYLDPMFPHKQKSALVKKEMRVFQSLVGPDLDADGLLEPARLLATKRVVVKRPDYAPPLANVTTPNAVVTKGHRFDIYAGTPV
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_CORU7
Sequence: MLAPEHRLRSSALFSTVVKKGARKGSRTLVVHLWTPEPGPDAPLELTGGPRAGLIVSKAVGNAVVRHAVSRKLRAVLATIIDEDATAASPQLQETSFVVVRALPGSAEASSKELESDVRRCLSRLSR
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: CBLN2_HUMAN
Sequence: MQAPGRGPLGLRLMMPGRRGALREPGGCGSCLGVALALLLLLLPACCPVRAQNDTEPIVLEGKCLVVCDSSPSADGAVTSSLGISVRSGSAKVAFSATRSTNHEPSEMSNRTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSGFLVFPL
What is the function of this protein?
Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity).  Essential for long-term maintenance but not establishment of excitatory synapses (By similarity).
What are the official names of this protein?
Cerebellin-2.
What are the subcellular locations of this protein?
Secreted.
Protein: OLE_PINEL
Sequence: MADQYHGVMQKIHDHTPNPTQILGFITLFVSGAILLLLTGLTLTGTVIGLVVLTPVLIFFSPILIPVATVLFVAVAGFLSAGGFGLAALSAISWLYNYIKGRHPPGADQIDYARMRIADTASHVKDYAREYGGYLQSKIQDAAPGA
What are the official names of this protein?
Oleosin.
What is the protein family that this protein belongs to?
Belongs to the oleosin family.
What are the subcellular locations of this protein?
Lipid droplet. Membrane; Multi-pass membrane protein. Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water interface.
Protein: CP4AE_MOUSE
Sequence: MGFFLFSPTRYLDGISGFFQWAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGHHLKDKELQQILIWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVLGRSDPKASGIYQFFAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVNIMLDKWEKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLDENSKLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAHEHTDGVIKMRKSQLQNEEELQKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDGTSVTWDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGRSIPKGITATISIYGLHHNPRFWPNPKVFDPSRFAPDSSHHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKSKNGIHLCLKKLR
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:17112342).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342).  Catalyzes the hydroxylation of saturated carbon hydrogen bonds of fatty acids (PubMed:17112342).  May act as a major omega- and ommega-1 hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342).  Catalyzes with low efficiency the epoxidation of 11,12-double bond of arachidonic acid (PubMed:17112342).
What are the official names of this protein?
Cytochrome P450 4A14, CYPIVA14, Lauric acid hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: POB3_DEBHA
Sequence: MVNTDFEKIHLNQSKNYGRMRIADSGLGWKASVTNNASASNNAPFLLPSEEILASQWSRGSRGYELRVQTKNKGVVMLDGFDVEDFANLKQELQRNFQVNLEHKEHSLRGWNWGKTDLARNELVFQVNNKPDFEIPYSEISNSNLTGKNEVAVEFNLDGANSKAGDEMVEMRFYIPGTLENETTPAVKNEENGEVKEEETEEISAATVFYEQLKDKADIGQVAGEAIVSFSDVLFLTPRGRYDIDMYPTSLRLRGKTYDYKIQYNQIERIFSLPKPDEAHHLLVIQIDPPLRQGQTKYPFLVMQFAKEEEIELDLNVSEEEYNDKYKDRLKKSYDSQTHLVMSHCFKGLTERRLVVPGSFQSRFLQPGISCSLKASEGYLYPLDRCFLFVTKPTVYIPFSEISSITMSRTGAGGVSTSRTFDMDITLRGSNQSHNFGSIEREEQETIENYCLQKGLRIKNEEKLAKAMLAKAMNETADDDDDADVDMGSAGDDDDESADDDFNSGSDSDVAEEFDSDASVSDAEMSDSNQEPPQKKPKNE
What is the function of this protein?
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.  It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
What are the official names of this protein?
FACT complex subunit POB3, Facilitates chromatin transcription complex subunit POB3.
What is the protein family that this protein belongs to?
Belongs to the SSRP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Protein: H19A1_CYRHA
Sequence: MNTVRVTFLLVFVLAVSLGQADEDGNRMEMRQEIEKTEADSSYFAENLLLQKLEELEAKLWEETSEESRNSRQKRCAAEGIPCDPNPVKDLPCCSGLACLKPTLHGIWYKHHYCYTQ
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
U9-theraphotoxin-Hhn1a, U9-TRTX-Hhn1a, Hainantoxin-XIX, HNTX-XIX.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 14 (magi-1) family. 01 (HNTX-16) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RIHA_SHEB5
Sequence: MTRHIILDCDPGHDDAIALILALAHPDLVPLAVTTSAGNQTPDKTLNNALRILTLLNRGDIPVAGGATKPLTRELIIADNVHGETGLDGPALPEPSFSPQAITAVELMAQQIRQSTQPVTLVPTGPLTNIALLLASHSELHPKIERIVLMGGAAGVGNWTPAAEFNIFVDPEAADIVFKSGIPITMCGLDVTHQAQIMDEDIERIRAIPNPIAQCVAELLDFFMIYHRDPKWGFIGAPLHDPCTIAWLLKPELFEAQDCWVGIETQSELTLGMTVVDRYQLTGKTANATVLFGLDRLGFVDLLVDSLRVYDPTYLNRR
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihA, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihA subfamily.
Protein: VIF_HV1B5
Sequence: MENRWQVMIVWQVDRMRIRTWKSLVKHRMYVSGKARGWFYRHHYESPHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKRRYSTQVDPELADQLIHLHYFDCFSDSAIRKALLGHIVSPRCEYQAGHNKVGSLQYLALAALITPKKVKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: C5IT1_RHIPC
Sequence: MATLIAARTKRKAPRVRIFEVRERGHTYVTKNVTVEDGACVYLRNVIPNGETKALNNPCVLSTCYAADRKVNSTLCPNIGVDEGCHVEWTPDGVYPNCCPKHVCPSATASS
What is the function of this protein?
Complement inhibitor (PubMed:31871188).  Prevents complement-mediated activation of C5 by sterically preventing direct binding of C5 to its convertase (binding with domains MG4 and MG5) (PubMed:31871188).  Binds C5 at a different binding site than the other tick complement inbibitors OmCI and RaCI3, and the drug eculizumab (PubMed:31871188).  Inhibits the complement in human, rat and guinea pig, and also shows a reduced inhibition in rabbit and pig (PubMed:31871188).
What are the official names of this protein?
Complement inhibitor CirpT1, Complement inhibitor from Rhipicephalus pulchellus of the terminal pathway 1.
What is the protein family that this protein belongs to?
Belongs to the CirpT family.
What are the subcellular locations of this protein?
Secreted.
Protein: PACC_SCLSC
Sequence: MSSQDQQQQQQPAQTQTSTSSSSNNENATTATSSIQQNVVADDSLLCQWEKCSERCPTPEALFDHICEKHVGRKSTNNLNLTCGWNSCRTTTVKRDHITSHIRVHVPLKPHKCEFCGKAFKRPQDLKKHVKTHADDSVLLRTPEQSGGSNGGYRQPGGKVIANLQHLAANPMGYYDHNASMHPGSAGVYGNSHHGGHSGYYAPAHSQQSSYGGGPGYYQMSHNPDLGQHAAWDEKKRNFDNLNDFFGAAKRRQIDAHSYQQVNQRLMQLQGIPIGTGGGISDYIHSAPQLVPIDGHGGHGHGGPMPQHQYSLPLPNLRTKSDLNSIDQFLEQMQSTVYESSNAAAAAGIHQPGAHYTHQALNFRQSHSPPQTHIHNIGSMAPHVSTSYASAPMTATHSSHSVSSGTPALTPPSSSVSYTSGNSPMSSSGMSPISRHSSTSNAAYPNLPAVTLGYSPHHSATAPTSTLGTNFDSDPRRRYSGGVLQRSAGGLNSSQYRESMETSTVGSPTPSPKETTPRPESIVKTEVTNNIDPALSDAGSPSVRSVDTLESARDRAEEAWIENIRVIEALRRYVSDRLQNGEYVKDEEDEDVSMADTDMQDTQVKTEEKPVESLYPVLKTDDDDE
What is the function of this protein?
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH.  At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pac1 itself) and represses transcription of acid-expressed genes (By similarity).
What are the official names of this protein?
pH-response transcription factor pacC/RIM101.
What is the protein family that this protein belongs to?
Belongs to the pacC/RIM101 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ATPF_VIBCH
Sequence: MNMNATLLGQAISFGMFVWFCMKYVWPPIIKAIEDRQKKIADGLQAAERAKKDLDLAQANASDQLKEAKRTATELIEQANKRKAQIIDEAREEAQAERQKILTQAEAEIEAERNRARDELRKQVATLAIAGAEKILERSIDKDTHKDILDNITAKL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: UPK1A_MOUSE
Sequence: MASAATEGEKGSPVVVGLLVVGNIIILLSGLALFAETVWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRYMILTYLLLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTYYSADTDQGQELTRLWDRIMIEQECCGTSGPMDWVNYTSAFRAATPEVVFPWPPLCCRRTGNFIPINEDGCRVGHMDYLFTKGCFEHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTTL
What is the function of this protein?
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells.  May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
What are the official names of this protein?
Uroplakin-1a, UP1a, Uroplakin Ia, UPIa, UPKa.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CADH7_RAT
Sequence: MKLGKVELCRFLQLIALFLCFSGMNQAELPRSRSKPYFQLGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGFIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNGPESLPVASVVARIKAADADIGVNAEMEYKIVDGDGLGIFKISPDKDTQEGIITIQKELDFEAKTSYTLRIEAANRDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGHIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGIITTAKSLDRETNPVHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAIDKDEPSNGHQFYFSLTTDMANNLNSSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDNGSPSLSSTNTLTIRVCDCDADGIAQTCNAEAYILPAGLSTGALIAILACVLTLLVLILLIVTMKRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVVRDTKTRRDVTPEIQFLSRPTFKNIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLGSLDSNSSNSDQNYDYLSDWGPRFKRLAEMYGNGQESLYS
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).
What are the official names of this protein?
Cadherin-7.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RLMM_SALPA
Sequence: MNKVVLLCRPGFEKECAAEITDKAGKREIFGFARVKENAGYVIYECYQPEDGEKLISELPFSSLIFARQWFVVGELLQHLPPEDRITPVVGMLQGVVEKGGELRVEVADTNESKELMKFCRKFTVPLRAALRDAGVLTNYETPKRPVVHVFFIAPGCCYTGYSFAHNNSPFYMGIPRLKFPSDAPSRSTLKLEEALHVFIPEDEWDERLANGMYAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFRYRPNRNNISWMVCDMVEKPAKVTALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYLQAQLDEHGVNAQIQARQLYHDREEVTVHVRRLWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_THET8
Sequence: MAYGKAHLEAQLKRALAEEIQALEDPRLFLLTVEAVRLSKDGSVLSVYVEAFREEEGALRALSRAERRLVAALARRVRMRRLPRLEFLPWRASPA
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes) (PubMed:17996707).  Required for efficient processing of 16S rRNA.  Probably interacts with the 5'-terminal helix region of 16S rRNA, bringing together different domains of the 30S ribosomal subunit which aids assembly (PubMed:17996707).
What are the official names of this protein?
Ribosome-binding factor A, 30S ribosome-binding protein.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Binds to the mature 30S ribosomal subunit.
Protein: PHS_STRAW
Sequence: MPVEPLSQKEIEDRLAELPGWSLDGDRISRSYRLGSHFAAAAMVVHIAQVQEELDHHSDLTLSYHTVSLTVNTHSVGGAVTELDFALARRVEDLAPGHGAS
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: KUP_PSEU2
Sequence: MSQANSHAEAGGAAKPIGLLIAAVGVVYGDIGTSPLYTLKEVFQGGYGVDVTHDAILGVLSLIFWSLIWVVSFKYMAFVLRADNQGEGGIMALMALARRASAKHPRLQMMMVVFGLFGAALFYGDSMITPAVSVLSAMEGLELAFDGLDHWIVPMALIVLVGLFLIQRHGTARIGVLFGPVMVTWFLVLGALGVYGIMQSPEVLKAVNPAWGVNFFIIHPGIGVAILGAVVLALTGAEALYADMGHFGRKPISRAWFILVLPALLLNYFGQGALVLGNPETVRNPFYLLAPGWALLPLIGLSTMATIIASQAVISGAFSMTLQAIQLGYIPRMHIQHTSSDAQGQIYIGAVNWALMAGVILLVIGFESSGALASAYGVAVTGTMLCTTILVSTVMLMLWKWPPLLAVPLLICLLLVDGLFFAANVPKIFQGGAFPVLAGAVLFILMTTWKRGKQLLAERIDEGGLPLPIFIGSIRVQPPHRVQGTAVFLTARSDAVPHALLHNMLHNQVLHEQVVLLTVVYEDSPRVPSAQRFEVESYGEGFYRVILHFGFIDEPDVPAALALCHLPELDFSPMRTTYFLSRETVIPSKMDGMARWREALFAFMLKNANGNLRFFKLPFNRVIELGTQVEM
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y114_SIRV1
Sequence: MNKVYLANAFSINMLTKFPTKVVIDKIDRLEFCENIDNEDIINSIGHDSTIQLINSLCGTTFQKNRVEIKLEKEDKLYVVQISQRLEEGKILTLEEILKLYESGKVQFFEIIVD
What are the official names of this protein?
Uncharacterized protein 114.
Protein: AAEB_ECO81
Sequence: MGIFSIANQHIRFAVKLATAIVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGFLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRIENSYAWGLAGYTALIIVITIQPEPLLTPQFAVERCSEIVIGIVCAIMADLLFSPRSIKQEVDRELESLLVAQYQLMQLCIKHGDGEVVDKAWGDLVRRTTALQGMRSNLNMESSRWARANRRLKAINTLSLTLITQSCETYLIQNTRPELITDTFREFFDTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWVAAATRYQLLKRGVISNTKINATEEEILQGEPEVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCISLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAVSAMTTNVARRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPINEDLSAFHRQMRRTADHVISARSDDKRRRYFGQLLEELEIYQEKLRIWQAPPQVTEPVHRLAGMLHKYQHALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSRP_RICRI
Sequence: MTEYKKVIAQNKKALFHYFIEERLEAGIVLKGSEVRSLRQGKASIEESHAADTGHEVFLYNCHIAEYEKANRFNHATRRPRKLLLHTKEIKKIIGRIRIKGYTLVALSMYFNKKNKVKVELGIAKGKKLHDKRESIKEKDWKRDQSRLIRQK
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SAHH_BARQU
Sequence: MAAQDYVVKDIALAAYGRKEIDIAETEMPGLMACREEFSFSQPLRGARISGSLHITIQTAVLIETLKAIGADVRWSSSNIFSTQDHAAAAIAATGTAVFGVKGETLEEYWAYIDAIFQWPDGNPSNLILDDGADATNYILTGSRAEVNKDILSYPKTKEEEFFFKQIQKRMKITPGFFTRQRTAIKGVSEETTTGVLRLYQLQKEGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRGTDVMIAGKTAIVCGYGNVGKGSAASLSGAGARVKITEIDPICALQAAMDGYEVVTLDDAASSADIIITTTGNKDVVRLDHMRQVKDMCILGNIGHFDNEIQVSALRNLPWTNIKPQVDIVTFPDGKRIILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELFTRAEHYKNEVTVLPKRLDEKVARLHLDRLGVKLSVLSEEQAVYIGVTPQGPYKPNHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPA2_SYNY3
Sequence: MHETDMTKALIMTIQDWFDQQVEKPQITKIHLLVGQFTCVEPVSLQFAFEVQTKQTFLNGAELVIKDVPLVAYCHTCQTEYSPEIGLQYSCPTCRSPMDDIRSGRELKIDRIEHHQCTPA
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA 2.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.