PharMolix/UniProtQA huggingface dataset:
Protein: RPIA2_YERPE
Sequence: MSNQQNDAKRAAARRVIQDFVFDGMTLGLGSGTTSHFFVRELGQHVAKGLQLTCTTTSRATSEVARDVGIELSDPNEMNEIDLTIDGPDEIDRRFNMIKGGGACLLWEKIIAHASKRMICICDETKIVNCLGQFPLPVEIVPFAWKQTERRVERVLAEQGLHHVPIIRRMGGGHPVITDSGNFILDCHCGAIITAPEPLEIELNRIPGVVENGLFTREATGMVVGYFDGSSYVQLR
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A 2, Phosphoriboisomerase A 2, PRI 2.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: IDI2_HALSA
Sequence: MTAQDSTQTEDRKDDHLQIVQERDVETTGTGFDDVHLVHNALPELDYDAIDPSIDFLGHDLSAPIFIESMTGGHHNTTEINRALARAASETGIAMGLGSQRAGLELDDERVLESYTVVRDAAPDAFIYGNLGAAQLREYDIEMVEQAVEMIDADALAVHLNFLQEATQPEGDVDGRNCVAAIERVSEALSVPIIVKETGNGISGETARELTAAGVDALDVAGKGGTTWSGIEAYRAAAANAPRQKQIGTLFREWGIPTAASTIECVAEHDCVIASGGVRTGLDVAKAIALGARAGGLAKPFLKPATDGPDAVIERVGDLIAELRTAMFVTGSGSIDELQQVEYVLHGKTREYVEQRTSSE
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRFA_PASMU
Sequence: MVVFLFILYRQSDLKFKSMNGVIIVNTLKKRLFVATTMIWGLSVTLPVLAEYKPIEQPVEPANPSLKIESRNDLFKEKYPKQYQTWADTSKSTDLDSVNYEDPRVIVLWAGYAFAKDYKKPRGHFYAVTDVREILRTAAPMTPDAGPMPMACWSCKSPDVPRLIAERGEAGYFGATWASGGSEVVNPIGCADCHDTTSKDFAEGKPALRIARPYVLRALEKIDHKFDTSDRTDQRAALCANCHVEYYFAGDLKQVTFPWDNGITVDAMEKYYDDIGFVDWTHAVSKAPMLKAQHPDYETWMLGVHGKNGVTCIDCHMPKVQGADGKVYTDHQIGNPFNAFEHTCANCHDQSKEKLQAMVKSRKTEIKDVMLRLEDQLVAAHFEAKAAWEAGATKEEMKEALQDIRHAQWRWDYAAAGHGGHIHAPDVLLKVIGTGLDKSSDARTKLVRVLAKHGITDPVQLPDISTAENAWKATGVDIEKERKAKAEFLKTVVPQWDKEAREKGLLPAEK
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SEPF3_STRCO
Sequence: MKSGEPVNSHDVTDEQWEGLAQVVPLRGRDAWPSAVGHRAMPEAETERRRRFVVLRINVFADAREVAETLMAGIPVLLDLTSAEGEVAKRVLDFSTGVVFGLASGMHRVDRNVFLLTPAGTEVNGLMESAAGVPGV
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF 3.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: SMPA_BRAHO
Sequence: MNKKIFTLFLVVAASAIFAVSCNNKTTNPTSNSSEKKIVTEEDFKNAIEGLTYKTWAFTGKGKSFNFGSPITVEATSGSDSLAGVEKGFGNALKSALAAKGIDTGNITFDKGGASSSDKTSVSFKFTPKALGTSNFEEKLKSSVKEVEIKLTPKENWGA
What are the official names of this protein?
16 kDa outer membrane lipoprotein.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: ESSB_STAAC
Sequence: MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHKGTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQTNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK
What is the function of this protein?
Component of the type VII secretion system (Ess).  Required for the secretion of EsxA and EsxB.
What are the official names of this protein?
Type VII secretion system protein EssB.
What is the protein family that this protein belongs to?
Belongs to the EssB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HSS_BLAVI
Sequence: MTDWPVYHRIDGPIVMIGFGSIGRGTLPLIERHFAFDRSKLVVIDPSDEARKLAEARGVRFIQQAVTRDNYRELLVPLLTAGPGQGFCVNLSVDTSSLDIMELARENGALYIDTVVEPWLGFYFDPDLKPEARSNYALRETVLAARRNKPGGTTAVSCCGANPGMVSWFVKQALVNLAADLGVTGEEPTTREEWARLAMDLGVKGIHIAERDTQRASFPKPFDVFVNTWSVEGFVSEGLQPAELGWGTFERWMPDNARGHDSGCGAGIYLLQPGANTRVRSWTPTAMAQYGFLVTHNESISIADFLTVRDAAGQAVYRPTCHYAYHPCNDAVLSLHEMFGSGKRQSDWRILDETEIVDGIDELGVLLYGHGKNAYWYGSQLSIEETRRIAPDQNATGLQVSSAVLAGMVWALENPNAGIVEADDLDFRRCLEVQTPYLGPVVGVYTDWTPLAGRPGLFPEDIDTSDPWQFRNVLVRD
What is the function of this protein?
Involved in the NAD(+)-dependent synthesis of the polyamine homospermidine from putrescine.
What are the official names of this protein?
Homospermidine synthase, HSS.
What is the protein family that this protein belongs to?
Belongs to the saccharopine dehydrogenase family.
Protein: YVBV_BACSU
Sequence: MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRTLIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIVFFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSAVSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLLFISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLLLIVTSICLVNTKSKAQKAAAIGINEKAAQ
What are the official names of this protein?
Uncharacterized transporter YvbV.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL2_TERTT
Sequence: MPIQKRKPTSAGRRFVVSVVNPDLHKGAPYAPLLEKKSKSGGRNNNGRITTRHIGGGHKQHYRKIDFKRNKDGIPAKVERLEYDPNRTAHIALVCYADGERRYIIAPKGLKAGDFIESGDASAIKVGNTLPLRNVPVGSVIHCIELKPGKGAQLARSAGASVQLVAREGQYATLRLRSGEMRKVEVECRATLGEVSNSEHSLRSLGKAGAKRWRGVRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGTPTKGYKTRSNKRTDKMIVRRRNKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: 11011_ASFK5
Sequence: MKVLLGLLLGYSVLILTHELPDLSATQHPPKEELAYWCTYVKNCDFCWDCQNDICKNKITNESISINSIVNCRVTRDSIHQWCFYEISVKMPNHHNMECSLPRPYTGNEIFMEKWGGGDYWPIIIRHCCFYLVFSIAFVGYIVFAYHKNLHLNTTMKLLALLSILIWLSQPGLNRPLSIFYMKQNLPRTYTPPVRELEYWCTYGKHCHFCWECRHGICKNKVWDDMPFIKQNDYISQCSIARYFDRCMYFIKPKTPYIHYMDCSQPTAYEGFSHS
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 110-11L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 110 family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: NQRD_ALIF1
Sequence: MASAKDIKKSILAPVLDNNPIALQVLGVCSALAVTTKLETAFVMTLAVMFVTALSNLFVSLIRNHMPNSVRIIVQMAIIASLVIVVDQVLKAYLYDISKQLSVFVSLIITNCIVMGRAEAFAMKSAPFPSFIDGIGNGLGYGFVLMTVAFFRELLGSGKLFGVEVLPLVSNGGWYQPNGLMLLAPSAFFLIGFMIWAIRILKPEQVEAKE
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBIE_RHIE6
Sequence: MSESRTSADGGMETSYGFREVPGGEKQGLVNQVFHKVAKRYDIMNDVMSMGMHRVWKDAMIAALNPRKEPGYKVLDVAGGTGDIAFRIVEASGRQAHATVLDINGSMLGVGAERAEKKKLSANLTFVEANAEELPFEAASFDAYTIAFGIRNVPRIDVALAEAYRVLKRGGRLLVLEFSEVDMPLLDKIYDAWSFNAIPQFGKAITGDAEPYQYLVESIRKFPNQENFAAMIRQAGFSRVSHTNYTGGIAALHSGWKL
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: PHNXL_SYNFM
Sequence: MEVFSRSNPYRGPVKGVVLDWAGTTVDYGCIGPLSVFVEVFRHNWVEVTIEEARAPMGLSREDHLRAMCRAESVARKWEDVHGAPPSEMDIGNMARMVEAHLAYTIAQHADLIPGVVEAVEALRGQGIRIGSSTGYTSDMMDMLVPAVEENGYRPDSIVCASDVPAGRPFPWMCYQNAINLEVYPMAAMVKIGDTVADIREGLNAGMWTIGLTLTGNELGLSEEEVAAMDPEELRRRMDNIEQRFRNAGAHFVAQGLRDCPAVIRDINELLAGGERP
What are the official names of this protein?
Phosphonoacetaldehyde hydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PhnX family.
Protein: MURC_FUSNN
Sequence: MIFGGIKSMEKIYFIGINGIGMSGLAKIMKCKGYDVKGADICTNYVTEELLSMGIVVYNEHDEENVKGADYVIASTAIKESNPELSYAKNNGIEILKRGELLAKLLNRETGIAVAGTHGKTTTSSMLSAVMLSKDPTIVVGGILPEIKSNAKPGKSEYFIAEADESDNSFLFMNPKYAVITNIDADHLDVHGNLDNIKKSFIKFICHTQKEAIICLDCENLKEVVTRLPEEKTVTTYSIKDESANIFAKNIKIEDRKTIFELYINKELIGEFSLNIPGEHNIQNSLPVIYLAFKFGVSKEEIQEALNKFKGSKRRYDVLFDKELENGYGNKTKRVRIVDDYAHHPTEIKATLKAIKSIDTSRLVAIFQPHRYSRVHFLLDEFKDAFVNVDKVILLPIYAAGEKNEFNISSEELKEHINHNNVEVMNEWKDIKRYVSRVKKDSTYIFMGAGDISTLAHEIAEELEGMSE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_PASMU
Sequence: MNEIKTADNAKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTDGPYQAVYVDTPGLHIEEKRAINRLMNRAASSAIGDVDLIIFVVDGTHWNEDDEMVLNKLRAAKAPVVLAINKIDNIKNKEEMLPFITELTSKFDFAHVVPISAQGGKNIAELEKIVRESLHEGTHHFPEEYVTDRSQRFMASEIIREKLMRFTGDELPYSVTVEIEQFKLNERGTYEINGLILVEREGQKKMVIGNKGQKIKQIGIEARADMERLFDNKVHLELWVKVKSGWADDERALRSLGYMDE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: SYC_BURTA
Sequence: MESLRIYNTLARDKQDFVPRQPGEVRMYVCGITVYDYCHIGHARMVVVFDIVQRWLRAAGYRVTYVRNITDIDDKIIRRALENGETIQSLTRRFIDAMNADFDALGVERPDIEPRATDFIPQMLGMIEKLEANGYAYQAKDGDVNYSVRKFANYGKLSGKSLEDLRAGERVAAKDAKDDPLDFVLWKRAKPEEPAGASWESKYGAGRPGWHIECSAMGCTLLGEHFDIHGGGQDLQFPHHENEIAQSEGATGQTFVNYWMHNGFVQVDSEKMSKSLGNFFTIREVLEKYDAEVVRFFIVRTHYRSPLNYSDVHLDDARASLTRLYTALKDVTPDAAPLDWSEAHAQRFAAAMNDDFNTAVAVAVLFELATEVNRTREPALARQLKRLAGLLGLLGREPREFLQQAAGAARTGALEPDEIEARIAARVAAKQAKNYAEADRIRAELLEAGIALEDKPGGSTEWRRV
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_DISPE
Sequence: MTNLRKTHPLMKIINHSFIDLPAPSNISAWWNFGSLLGICLTIQIMTGLFLAMHYTSDTSTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHVGRGLYYGSYMYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVIVHLLFLHETGSNNPSGINSNSDKIPFHPYYTIKDMLGLVLMLLSLLTLSLFSPDLLGDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLIIPLLHTSKQRSLMFRPISQTLFWLLTANLLTLTWIGGQPVEQPFIIIGQLASIIYFLLIMVFMPLAGLLENYMLKPKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SEC20_MOUSE
Sequence: MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSELTELNTKVKEKFQQLKQRIQELEQSAREQDKESEKQLLLQEVENHKKQMLSNQTSWRKANLTCKLAIDNLEKAELLQGGDSLRQRKTTKESLAQTSSSITESLMGISRMMSQQVQQSEEAMQTLVSSSRTLLDANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL
What is the function of this protein?
As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization.  Also plays a role in apoptosis.  It is for instance required for endoplasmic reticulum stress-induced apoptosis.  As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy.
What are the official names of this protein?
Vesicle transport protein SEC20.
What is the protein family that this protein belongs to?
Belongs to the SEC20 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein. Note=Localization to the mitochondrion is regulated by RNF186.
Protein: CP1A1_OPSTA
Sequence: MALIILPFIGSLSVSESLVALITICVVYLILTYSHTKIPAGLQRLPGPKPLPIIGNVLEIGRKPYQTLTALSKRYGPVFQIQIGMRPVVVLSGSETVRQALIKQGEDFSGRPDLYTFQFISDGKSLAFSTDKVGVWRARRKLAYSALRSFSSLESTNQEYSCMLEEHICKEGEYLVKQLNTSMKANGSFDPFRNIVVSVANVICGMCFGRRYDHYDQELVSLVNLSEEFGQVVGTGNLADFIPVLRFLPSTAMKKFLSINDRFDKFVKKIVSEHYATYNKDNIRDITDSLIDHCEDRKLDENCNVQVSDEKIVGIVNDLFGAGFDTVSTGLSWSVMYLVAYPEIQERLYQEIKDSVGTERMPLLSDRPSLPFLDAFILEIFRHSSFLPFTIPHCTTKNTSLNGYFIPKDTCVFINQWQINHDPELWKDPFSFNPERFLSADGTELNRLEGEKVMLFGLGKRRCIGEVIARNEVFLFLAIIIQRLQFHMLPGEPLDMTPEYGLTMKHKRCQLRATMREKNEQ
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 1A1, CYPIA1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: RS15_STAAW
Sequence: MAISQERKNEIIKEYRVHETDTGSPEVQIAVLTAEINAVNEHLRTHKKDHHSRRGLLKMVGRRRHLLNYLRSKDIQRYRELIKSLGIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: FTSW_METCA
Sequence: MSTQAIRGARGLVLKWGAGRFYLDTVLLSVSLGLMLFGFVMVSSASLHLGEKMASDSFYFPKHQLVHILLGLAAGWGAARVRLDTLERHSRSLFWAGIALLVLVLIPGVGKSVNGSVRWINLFGLRVQVSEVFKLVAAIYVAGYISRHLDTVRTSVKGMIFPLSLLAIGAVLLLKEPDFGATAVVMATALGMLFLAGARLWVFVGLLGLVAVAGTVLIYTAEYRLRRVLSFLDPWADPLNSGFQLTQALIAFGRGEWQGVGLGSSVQKLFYLPEAHTDFLFSVIGEELGLWGATTVILLFAIVVWRALAIGRLAERSGNLFAAFLAYGIGIWLGLQSFINMGVNMGMLPTKGLTLPLMSYGGGSMMVVCAAIGLLFRIRSEAVASFLGNGRKGLWPGV
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: Y3007_YERPS
Sequence: MYDNLKSLGITQPEDVDRYSLRQEANNDILKIYFRKDKGEFFAKSVKFKYPRQRKTVVSDNASHGYKEINEINPNLRYVIDELDQLCKRDQIEVDLKRKILDDLRHLESVVTNKIAEIEADLEKLTNGR
What are the official names of this protein?
UPF0325 protein YPTB3007.
What is the protein family that this protein belongs to?
Belongs to the UPF0325 family.
Protein: IL1A_MACMU
Sequence: MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYDVSYGPLHEGCMDQSVSLSISEISKTSKLTFKQSMVVVSTNGKVLKKRRLSLSQSITDNNLEAIANDSEEEIIKPRSAPFSFLSNMTYHFIRIIKHEFILNDTLNQTIIRANDQHLTAAAIHNLDEAVKFDMGAYTSSKDDTKVPVILRISKTQLYVSAQDEDQPVLLKEMPEINKTITGSETNFLFFWETHGTKNYFISVAHPNLFIATKHDNWVCLAKGLPSITDFQILENQA
What is the function of this protein?
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems.  After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex.  Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.  In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways.  Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.  In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
What are the official names of this protein?
Interleukin-1 alpha, IL-1 alpha, Hematopoietin-1.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Recruited to DNA damage sites and secreted after genotoxic stress.
Protein: RL18_XANOR
Sequence: MSINKNIARLRRAKSTRSHIRELGVARLSVLRTGQHLYAQVFTADGSKVIAAANTLQADVKDGLKNGKNSDAAVKVGKLIAERAKAAGIEKVAFDRSGYRYHGRIKALADAAREGGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: APTH1_YEAST
Sequence: MNGLRVAAKIQPARQTIIFLHGLGDTGSGWGFLAQYLQQRDPAAFQHTNFVFPNAPELHVTANGGALMPAWFDILEWDPSFSKVDSDGFMNSLNSIEKTVKQEIDKGIKPEQIIIGGFSQGAALALATSVTLPWKIGGIVALSGFCSIPGILKQHKNGINVKTPIFHGHGDMDPVVPIGLGIKAKQFYQDSCEIQNYEFKVYKGMAHSTVPDELEDLASFIKKSLSS
What is the function of this protein?
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates.  Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins.  Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
What are the official names of this protein?
Acyl-protein thioesterase 1, Palmitoyl-protein hydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RDRP_ROTW3
Sequence: MGKYNLILSEYLSFIYNSQSAVQIPIYYSSNSELENRCIEFHSKCLENSKNGLPLKKLFVEYSDVIENATLLSILSYSYDKYNAVERKLVKYAKGKPLEADLTVNELDYENNKITSELFPTAEEYTDSLMDPAILTSLSSNLNAVMFWLEKHENDAAEKLKIYKRRLDLFTIVASTVNKYGVPRHNEKYRYEYEVMKDKPYYLVTWANSSIEMLMSVFSHEDYLIARELIVLSYSNRSTLAKLVSSPMSILVALVDINGTFITNEELELEFSNKYVRAIVPDQTFDELKQMLDNMRKAGLTDIPKMIQDWLADCSIEKFPLMAKIYSWSFHVGFRKQKMLDAALDQLKTEYTEDIDDEMYREYTMLIRDEVVKMLKEPVKHDDHLLQDSELAGLLSMSSASNGESRQLKFGRKTIFSTKKNMHVMDDMANGRYTPGIIPPVNVDKPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLIYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNSMVLYTDVSQWDSSQHNTQPFRKGIIMGLDMLANMTNDARVIQTLNLYKQTQINLMDSYVQIPDGDVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRISNKYSFATKIIRVDGDDNYAVLQFNTEVTKQMVQDVSNDVRETYARMNAKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAVLYSNYIVNRLRGFETDREFILTKIMQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQKSGIADEIAASSTFKNYVSRLSEQLLFSKNNIVSKGIALTEKAKLNSYAPISLEKRRAQISALLTMLQKPVTFKSSKITINDILRDIKPFFTVSEAHLPIQYQKFMPTLPDNVQYIIQCIGSRTYQIEDDGSKSAISRLISKYSVYKPSIEELYKVISLHENEIQLYLISLGIPKIDADTYVGSKIYSQDKYRILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEVINHAIKNGSWISLFCNYPKSEMIKLWKKMWNITSLRSPYTNANFFQD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).