PharMolix/UniProtQA huggingface dataset:
Protein: RNP4F_DROME
Sequence: MDADKQLERQLEKELDEMPAEDLDDDAYDEYDLIVIPDQGKGSPQQGHSESPQQEEEHKSEELRQRSRPTWPPSSAGGDMTTIELISSDDEPSVEETEGGNAAGRGRARNDSSSSSDDVGVIEGSELESNSEVSSDSDSDSDNAGGGNQLERSYQELNALPSKKFAQMVSLIGIAFKLNDLEKIESSVLELQNLATVPAHVWLKYLKARLVVTQTDEERKAFEEQCAKALGYYYSIPLSEYVVNYLVDQGNVQNHVLWAKLLADYDVERPDFGDKLRSLISTITDENEAAAFVEMLQKHCVTWTCNVEQRQMIKSVVDKFKQHLDETTRGWDWSEQHKAHVYDVETLSLDDDLKNAVIRFIFERSVAKFPIVDVLWLSYIEFIQFEGVTVPENEDENEVTAEMVAKRAKRLGKGFLRNTELDLANRGVRSHPSVQLNHRFLDLMERSDFELAEVDEEIRLILQRIVTDMDMTVELHLDYLAYRIRNTNASDEQQVASLRAAFNHAWEELTVLYGDQADTRYEVLQLWAQVEYTQLGSPDNGREIWRQIMGYPGSSIRGLLWLNFAQMESEYNGGHGTRDVLRKALSQPVLENGLMVQEFFRRYERCYGTYESIAACQALDLPVEYVKPRSRIKPNSQSAYPRQQKLKPRQQQQQTNREPLNREQRRRQAHEQQQQQQQQQKHGIKKSRTEPSGGATSPPSKVKGPANAEAKESNFKYSPNMEINKIFVRNLHPACSKEELHELFSPFGTIKDVRLVHKLNKQFKGIAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAISNPPPRGTSAVKPSVAPKRRVPTSLIPTTLVRQEVAAKKLRLLLPEPGDISSTSASVDVAIKREANGEEQKGDVQERDEQKGEEQKGEEQKGEEPKGEEQKGDDQIGEEQSGVEQKGDEKKEEEMPAAVPKSNDDFRKLFLKD
What is the function of this protein?
May be involved in gene regulation during development.  Binds RNA.
What are the official names of this protein?
RNA-binding protein 4F.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_METSB
Sequence: MYDIKWIRDNPEVFDQGRKRRGLEPLAARLLELDDARRGAIAKLQVAQERRNAASKEIGQAMAAKDQAKADALMAEVSALKRDLPELEAAERAAAALLDKALSEIPNLPLEEVPFGRDENDNREHHTFGEKPRFSFDPAEHYELGETLGLMDFETAAKLSGARFVVNKGPLARLERALGAFMLDLHTGEHGYTEVNPPILVRDDAMFGTAQLPKFENDQFWARPGAHPLLIDMFGREEAEEMKKNRLWLIPTAEVPLTNLVRESILDEKQLPLRFTASTPCFRAEAGSAGRDTRGMIRQHQFTKVELVSITTPEQALAEHERMLSCAEEVLKRLKLPYRVVTLCTGDMGFASQKTYDIEVWLPGQDRYREISSVSVCGDFQARRMNARYRPEGAKNTRFVHTLNGSGVAVGRALVAVLENYQTEDGSIIVPDALAPYMGGITRIEKPALERPNSEKPVSRA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PT511_ARATH
Sequence: MGKGGALSESVIKNIVLSYSYVAIWIFLSFTVIVYNKYILDKKMYNWPFPISLTMIHMSFCSTLAFLIIKVFKFVEPVKMTRETYLRSVVPIGALYALSLWLSNSAYIYLSVSFIQMLKALMPVAVYSIGVLFKKEGFKSDTMMNMLSISFGVAIAAYGEARFDVWGVILQLGAVAFEATRLVLIQILLGDKGIKLNPITSLYYVAPCCLAFLFIPWIYVEFPVLRDTSSFHLDYAIFGANSFCAFALNLAVFLLVGKTSALTMNVAGVVKDWLLIAFSWSVIKDTVTPINLFGYGIAFLGVAYYNHAKLQALKAKEEEKKKIQQADEESGRLLEEREGDVEGKKNDQSGN
What are the official names of this protein?
Probable sugar phosphate/phosphate translocator At5g11230.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. TPT (TC 2.A.7.9) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DEOC_ECOSM
Sequence: MTDLKASSLRALKLMDLTTLNDDDTDEKVIALCHQAKTPVGNTAAICIYPRFIPIARKTLKEQGTPEIRIATVTNFPHGNDDIEIALAETRAAIAYGADEVDVVFPYRALMAGNEQVGFDLVKACKEACAAANVLLKVIIETGELKDEALIRKASEISIKAGADFIKTSTGKVAVNATPESARIMMEVIRDMGVEKTVGFKPAGGVRTAEDAQKYLSIADELFGADWADARHYRFGASSLLASLLKALGHGDGKSASSY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATB_METLZ
Sequence: MKEYKTVSKVAGPLLFVEKTEPVSYEEQVSLVLADGTMKRGQVLDTSEDLVVVQCFETTTGLGRDTGVRFLGETFKMPVSKTMLGRILSGGGKPIDGGPAIVPDKRLDINGAAINPYARGTPRDFIQTGISTIDGTNTLVRGQKLPIFSSAGLPHNEIALQIARQAKVPGSSDEFAVVFAAMGITREEANYFMADFERTGALERAVVFLNLADDPAVERTVTPRLALTTAEYLAYELGYHVLVILTDMTNYCEALRQIGAAREEVPGRRGYPGYMYTDLASIYERAGIIKGLKGSVTQIPILTMPGDDITHPIPDLTGYITEGQIVISPELHRKGIYPPINVLPSLSRLMNLGIGKGMTREDHKKVSDMMYSGYAEGVDLRGLVAIVGKDALSERDQKFLEFADAFEDKFVRQGSDEDRTIAQTLDVGWGMFTQLPESELEKRIDRDLIKTYHPNYRK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: M1_I18A0
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEVALSYSAGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKDDLIENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: GSFJ_PENAE
Sequence: MDKQNTDSEKRATAEAPPQSLCTLVSSSEQGGMDITNHNAKAGAADEYPHGVRLAAVVFSLMLGMFLVALDNTILGTAIPKITDEFHDLNKVSWYGSAYLMTFGCGFQSTWGKFYKYFPIKVWFLVAVFIFEVGSLICAVAQNPTTLIVGRAIAGFGGSGVGVGIFTIIGFAAPPENRPQLLGFTGATYGIAAVLGPLIGGAFTDKCFYINLPIGGVAAGTIFLLFKPPTSASPAKATPKEKFLQMDLVGATLMMGLIVSYILALQYGGQTHSWKSSEVIGLLVGFFLFVLAFVTWEIYQKERAMIVPRLFMRRYISVGSIYMFFFSGAYFIILYYLPIYFQSVYNSSPIGSGVKMLALIIPLTLAAIVQGWALSKIRIVPLFWIIGGALGTVGCGLFYTFDTETSVGKWVGYQIIVGFSTGWTFQIAMSNAQVHAPPEDMSQATAIVNFFMTVGGAFFISAAQCAFSNQLIKTITKNLPELDPTVAISTGATQIREAFTASQVPIVVDAYMVGLKAVFAITIAAFGVATVIGFFGSWKKLLADELEKATGGVA
What is the function of this protein?
Probable efflux pump; part of the gene cluster that mediates the biosynthesis of griseofulvin.
What are the official names of this protein?
Probable efflux pump gsfJ, Griseofulvin synthesis protein J.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NU4C_GLOVI
Sequence: MQNMFPWLTVIILLPLVAALAVPLIPEKQVKWYSFAVCLVDFVLMVAAFFTSYDLSNPDIQLAERYRWMPQIGLEWSVGADGLSMPLILLTGFITALATLAAWPVTLRPRMFHFLMLAMLAGMVGVFAVQDMVLFFLFFELELVPVYLMLAIWGGKGRLYAATKFILYTAVGSLFILVVGLAMYFYGDLRTFNMVELAAKNYDPTFQNLCFLGLLIAYAVKLPIFPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALIRMNVGFFPEATQLFAPLLIVLGIVNIIYAALTSFGQRNLKRKIAYSSISHMGFVLIGVGSLSEIGMGGAMLQMISHGLIGASLFFLVGATYDRTHTLILSEMGGIAPKMPKIFAMFTACSMASLALPGMSGFVAELMVFVGMATTDAYSFQFKALVVLFAAFGVILTPIYLLSMLREIFYGTLNHAVVHEEDLVDAEPREVFIIASLLVPIFGIGLYPKLTTDLYAPTTDQLTRVTRERIARAAPPPALLSGVYSVEFADRDRVSLR
What is the function of this protein?
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, NAD(P)H dehydrogenase I, chain 4, NDH-1, chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TPIS_TRIEI
Sequence: MRKTIIAGNWKMYKTQLEAKEFLEGLMSQLTKTPEEREVVLCTPFTALDFMSKILHGSLIRLGAQNVHWEDEGAYTGEISGLMLKDVGVSYVIVGHSERRQYFGETDETVNMRLKAAQKHGLTPILCVGETKQQRDSGETESHIFSQLANDLVDVDQENLVIAYEPIWAIGTGDTCEAKEANRVIGLIRGKLNNSNVTIQYGGSVKPNNVDDIMAQEEIDGALVGGASLNPESFSRLVNYQ
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU3M_HYLLA
Sequence: MNLALALMINTLLALLLMTITFWLPQLNTYMEKTNPYECGFDPLSPARIPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNPSLTIASSLTLITILILSLAYEWSQKGLDWVE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CISY_BARVI
Sequence: DGNKGILLYRGYPIEQLAEKGDFLESCYLLLYGELPTQQEKSDFDRCIMQHTMVHEQFARFFHGFRRDSHPMAVMVACLGAMSAFYHDSIDITDPQQRMIASVRLISKVPTLAAMAYKYSIGQAFVYPRNDLSYAANFLRMCFSVPCEEYKTNPVLTRAMDRIFILHADHEQNASTSTVRLAGSSGANPFACIAAGVACLWGPAHGGANEACLKMLQEIGSVKRIPEFIARAKDKNDPFRLMGFGHRVYKNYDPRAKIMQKTCHEVLKELNIQDDPLLDIAIELEKIALNDEYFVEKKLYPNVDFYSGITLKALGFPTE
What are the official names of this protein?
Citrate synthase.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
Protein: SSRP_SYNP6
Sequence: MADSGGIKVLSENRQARFQYEILETFETGIELLGTEVKSIRAGKVNLRDGFALVRNGEVWLHNIHISPHQQASAYYNHDPLRTRKLLMHREEIRKLIGKVEQKGLTLVPLKMYLKQGWVKVTLGLGRGKKLHDKRETERRRQDQRDIQRAIKRA
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RL18_STACT
Sequence: MISKIDKNKVRLKRHARVRSNLSGTAQKPRLNVYRSNKHIYAQIIDDTKGVTLVQASTQDKDFENETGSKVELSSKVGEAIAKKAADKGITEIVFDRGGYLYHGRVKALADAARENGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: Y1524_POLAQ
Sequence: MVNILKKRAFGGAILAALLLASSAYVGAQSAPAAGAQGKTELLWFGQAGFRIKTPQGKMILIDPWITGGPKTPPMYKNDLAAIGPIDLLLVTHAHVDHLGDAPTIAKTNNTKLYGPADMVTPLTTLGVLPAELGYRFNKTGQVTPLPGIKVTAVQAEHSSLLVWKNPATDKLESHPAGEPMGYIIELENGFKIWHMGDTGLFSDMKFISEHYKPDLVLIPIGGNFTMAPDDAAYALRTWVKPKMVIPMHYNSNPMTKGTLAEFQAAMKGSNIKVIPMTEGETVQF
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Pnuc_1524.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: ARGD_METJA
Sequence: MSQENWIDLEKKYHLQIYGRLPVVLVEGKGMEVYDIDGKKYLDFLAGIGVNNVGHCHPKVVEAIKKQAETLIHTSNIYYTIPQIKLAKKLVELSGLDRAFFCNSGAEANEGAIKFARKYVSKVLGREGGEIISMYNAFHGRTLTTLAATPKPKYQDGFYPLPPGFKYVPFNDIEALKEAITDKTAAIMIEPVQGEGGIHVADKDYLKAVRDLCDDKNIVLIFDEVQCGMGRTGRMFAFEHYGVEPDILTLAKALGGGVPIGAVVLKEEIAKALSYGDHGTTFGGNPLACSAALASVEVIEELIKDDKVIEKGKYFIRKLENLIEKYNFIKEVRGLGLMIGAELEFNGADIVKKMLEKGFLINCTSDTVLRFLPPLIVEKEHIDALINALDEVFTEIKK
What are the official names of this protein?
Acetylornithine aminotransferase, ACOAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBB_DAUCA
Sequence: MGLPWYRVHTVVLNDPGRLLAVHIMHTALVAGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITSSWGGWSITGGATPNPGIWSYEGVAGAHIVFSGLCFLAAIWHWTYWDLAIFCDERTGKPSLDLPKIFGIHLFLAGLACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQSVNPAWGVEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSAGLAENQSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPIFRDKEGRELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGAFQKLGDPTTRRQTV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PURA_LEUMM
Sequence: MSGVIVVGSQWGDEGKGKIVDFFAEHADAVVRYQGGNNAGHTIWHGDTKFELSALPSGIVTKGQLAILGNGVVINPEALLAEIKEVESQGVTVENLIISNRAHVIMPYHIALDKASETASNNRIGTTKKGIGPAYTDKISRVGIRVADLIDPEIFGKLLKEYLPFKNAQLTKLYGEEALDYNEIYDKYVEYGRQLAPYVTDTSYLLGQQMKENKRVVFEGAQGVMLDVDHGTYPFVTSSNPTAGGVMNGAGVGPKQIQDVVGVIKAYTSRVGSGPFPTELFNDTADHIREIGHEYGVVTKRPRRIGWLDAVALRHAVQVSGLTKLAINSLDVLSGLKEVKIATSYTYKGEEIHHFPASDTWFQGLDVNFETLPGWDEDITDVTKFDELPINAQNYLKRISELLEVDLLSFAVGPKPEQTHLLRPVWE
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_IDILO
Sequence: MKQYLQLCQRIVDEGVWVKNERTGINCLTVINADLEYDVANNQFPLITTRKSYYKSAIAELLGYLRGYNSAAQFRDIGCKTWDANANENQAWLNNPNRKGEDDMGRVYGVQGRSWQKPDGSHLDQLKKVINNLSKGIDDRGEIVTFYNPGEFELGCLRPCMHTHNFSLLGDTLYLTSYQRSCDVPLGLNFNQIQCFALLALVAQITGHKPGKAYHKIVNAHIYENQLELMRDVQLKREPFPSPQLHINPEIKSLEDIETWVSKDDFIVSGYQCHDPIKYPFAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMF_PSEPG
Sequence: MTEKPTLHPRNRHQGRYDFPSLIKAHPDLARFTITNPHGKPSIDFANPEAVRVFNRALLKAQYGIQHWDIPADYLCPPIPGRADYIHVAADLLADDNAGEVPKGAQVRALDIGVGANCIYPLLGHSDYRWRFLGSDIDPVALASAKAIVQANGLGKAIILRQQANRAHILSGLLQEGERFDLTLCNPPFHASRDEATRGSQRKWKNLGKQDPKRKLPVLNFGGQNNELWCEGGEIRFVSQLVGESVQYAERVLWFTSLVSKASNLPGIEAALKKAGAKAVRIIEMGQGQKQSRMVAWSFHDAAARLAWHAQRKSQA
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_SYNY3
Sequence: MKAIMVVGTTSHAGKSFLTTGLCRLLRRRGDRVTPFKGQNMALNAFVTIDGGEMGHAQAVQAWAAGTVPRVAMNPILLKPQGDMTSQVIMLGQAVGTTRAQEYYQNYFDRGWQAIANSLETLAQDFDVVVCEGAGSPAEINLKHRDLTNMRVATHLQAATILIADIDRGGVFAHVVGTLQLLEPEERKLIKGIVINKFRGQRSLLDSGITWLEEYTGIPVLGVIPYGQNLFSAEDSLDILERSGRPSKEDIRIVVLRLPRIANFTDFEPLEAESGVYVDYLPLEKQLGNPDAVIIPGSKTTIADLQALQNSGMAQQIMDYAQAGGTVMGICGGYQMLGQTIADPENIEGNVSNCQGLGLLPLTTVINQEKITRQCQTITHAPPSGLTVTGYEIHQGLSRRSEHSQDFLPMFDQEELGMVNAQQNLWGCYLHGLFDNGAWRRCWLNNLRQRRGLDPLPTSIGNYQEQREGMLDSLADFVETHVNLEPILQSLPEENETP
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity).
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: THIC_ANAPZ
Sequence: MHMNISEIYPSSNKIYINCTLYPDVKVGMRQINIRNSSQRFLLYDTAGPYTDCDIKVNLTEGISSIRRDWIARRNDTYPIRKAKTNSDARGVKALSGDDRVILKGIAGGAPVTQLFYAKKGIITPEMEYVAVRENALLEQAEAIPGLLLPTKTRKITPEFVREEVACGRAVIPSNINHPESEPMIIGRNFLVKINANIGNSAVLSNIEDEVKKMVLAVTYGADTVMDLSTGHDIHNIRELIVRNSPVPIGTVPIYQALNKVNGIVGDLSFEVFKETIIEQAEQGVDYFTIHAGVLKSYIEHTRSRTTGIVSRGGAIMAQWCLLHNKENFLYENFEEICEIMRSYDVTFSLGDGLRPGSINDANDVAQFLELRTLGELVKIARAHDCQVIVEGPGHVPMHLIEENVKKQLDFCDEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAMLCYVTPKEHLGLPNAEDVKAGVISYKIAAHAADLAKGNPASFARDYALSQARYDFRWEDQFNLSIDPATAKKLHDESLPGKGGKTAHFCSMCGPKFCSMKLSKALND
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: ANNU_SCHAM
Sequence: MGNCCSTFRAVFKPNEGSGGGIPLMPVRGGSTRRPDSLPKPPAAVVPSPPSPGDVPDAGVAPEVASVKEVDVLLAENGDAHRTRHYELMDREKEPRLVVRRGQPFAVSVTLSRPYNPDIDAISFVFTVEDAEKPSYGQGTLVAVPLLAKGAESGAAWNAVLDSSADDILRIQITPAADAIVGKWKMDIDTKLKNDGAVSYSYKDPFYILYNPWCRQDQVFLEGEELLQEYVLNDTGLIWRGSYNRLRPCVWKYAQFEKEILDCALYLVSKIGGVRPSECGDPVRVCRAISAAVNSPDDNGAVMGNWSNDYGGGTPPTKWIGSMKILQQFYKNKKPVKYGQCWVFAGVLTTVCRALGLPARTVTTYSAAHDTQNSLTVDYFVDDKGEIMEEMNSDSIWNFHVWTEVWMERPDLMPGDGAHYGGWQAVDSTPQELSDNMYRCGPAPVVAVKQGEVLRPYDSAYVFAEVNADKVFWRYSGPTQPLKLIRKDMLGIGQNISTKAVGRFQREDITNTYKYPEKSVEERAAMLKALRQSESLFSRYYLNEDFNDIHFNFELRDDIVIGSPFSVVVVMKNRSNQQDYTVTVLLRVDTVLYTGHVKDGVKKEKVERLIKAGAVEEVRIDVSYEDYYKHLVDQCAFNIACLATVHDTNYEYFAQDDFRVRKPDIKIKLEGEPVQGQEMSAVATLKNPLPIPVKKGQFLIEGPGIAKTQKIKLSQNIAPGEEASVNFKFTPKYDGRATIAAKFSSKELDDVDGFLNFMVEPKKEVNGTGNAA
What is the function of this protein?
Participates in morphogenetic activities of the cells, maybe by stabilizing the membrane or subcortical structures of cells that are under mechanical stress.  Probably catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
What are the official names of this protein?
Annulin, Protein-glutamine gamma-glutamyltransferase, Transglutaminase.
What is the protein family that this protein belongs to?
Belongs to the transglutaminase superfamily. Transglutaminase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Intracellular and peripherally associated with the inner leaflet of the cell membrane, using a fatty acid linkage.
Protein: BETA_SERP5
Sequence: MEYDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRMDFRTQMPAALAFPLQGRRYNWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDNWAKAPGLEDWSYLDCLPYFRKAETRDIGPNDFHGGDGPVSVTTPKAGNNELFHAMVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARSRPNLKIVTHALTDRIRFDGKRAVGVDYLQGEAKDVTSARARREVLLCAGAIASPQILQRSGVGPAALLNRLDIDLVHELPGVGENLQDHLEMYLQYACKKPVSLYPALQWFNQPKIGAEWLFNGSGIGASNQFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRVQVKSKDPRQHPSILFNYMATEQDWQEFRDAIRITREIMAQPALDEYRGREISPGPEVQTDEQLDAFVREHAETAFHPSCSCKMGEDEMAVVDGQGRVHGLEGLRVVDASIMPLIITGNLNATTIMIAEKIADRIRQRTPLPRSTAEYYVAGNAPARKQ
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: A311_LOXLA
Sequence: MYAHLALILGCWTVVLQGAETDVGERADNRRPIWNLAHMVNAVAQIPDFLDLGANALEADVTFKGSVPTYTYHGTPCDFGRDCIRWEYFNVFLKTLREYTTPGNAKYRDGFILFVLDLKTGSLSNDQVRPAGENVAKELLQNYWNNGNNGGRAYVVLSLPDIGHYEFVRGFKEVLKKEGHEDLLEKVGYDFSGPYLPSLPTLDATHEAYKKAGVDGHIWLSDGLTNFSPLGDMARLKEAIKSRDSANGFINKIYYWSVDKVSTTKAALDVGVDGIMTNYPNVLIGVLKESGYNDKYRLATYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) with high activity (PubMed:12419302, PubMed:14732720).  It also act on acyl- and alkyl-lysophosphatidylcholine (LPC), but not on sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC) (PubMed:14732720).  It may also act on ceramide phosphoethanolamine (CPE), and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces complement-dependent hemolysis and dermonecrosis (PubMed:12419302).  Also induces increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LlSicTox-alphaIII1i, LlH17, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D 1, Lox-SMaseD, SMD 1, SMase D 1, Sphingomyelinase D 1, Sphingomyelinase I, SMase I.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class I subfamily.
What are the subcellular locations of this protein?
Secreted.