PharMolix/UniProtQA huggingface dataset:
Protein: FTSY_NEIMA
Sequence: MFSFFRRKKKQETPALEEAQIQETAAKAESETAQVIENIKEDAESLAESVKGQVESAVETVSGAVEQVKEAVAEMLSEAEEAAEKAAEQVEAAKEAIAETVGEAVGQVQEAVATTEEHKLGWAARLKQGLTKSRDKMAKSLAGVFGGGQIDEDLYEELETVLITSDMGMEATEYLMKDVRDRVSLKGLKDGNELRGALKEALYDLIKPLEKPLVLPETKEPFVIMLAGINGAGKTTSIGKLAKYFQAQGKSVLLAAGDTFRAAAREQLQAWGERNNVTVISQTTGDSAAVCFDAVQAAKARGIDIVLADTAGRLPTQLHLMEEIKKVKRVLQKAMPDAPHEIIVVLDANIGQNAVNQVKAFDDALGLTGLIVTKLDGTAKGGILAALASDRPVPVRYIGVGEGIDDLRPFDARAFVDALLD
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).  Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
What are the official names of this protein?
Signal recognition particle receptor FtsY, SRP receptor.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. FtsY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: YRBD_BACSU
Sequence: MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMIVQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGAASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQSNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSLIIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPAAAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVEAGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAMLGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQKKQGLDPIFDPKALGIKNADFWEKEYTHESERVS
What are the official names of this protein?
Putative sodium/proton-dependent alanine carrier protein YrbD.
What is the protein family that this protein belongs to?
Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ZDH15_HUMAN
Sequence: MRRGWKMALSGGLRCCRRVLSWVPVLVIVLVVLWSYYAYVFELCLVTVLSPAEKVIYLILYHAIFVFFTWTYWKSIFTLPQQPNQKFHLSYTDKERYENEERPEVQKQMLVDMAKKLPVYTRTGSGAVRFCDRCHLIKPDRCHHCSVCAMCVLKMDHHCPWVNNCIGFSNYKFFLQFLAYSVLYCLYIATTVFSYFIKYWRGELPSVRSKFHVLFLLFVACMFFVSLVILFGYHCWLVSRNKTTLEAFCTPVFTSGPEKNGFNLGFIKNIQQVFGDKKKFWLIPIGSSPGDGHSFPMRSMNESQNPLLANEETWEDNEDDNQDYPEGSSSLAVETET
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:18817523, PubMed:23034182).  Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).  Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (PubMed:18817523).  Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (PubMed:18817523).  In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (By similarity).  Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity).  Could also catalyze the palmitoylation of GAP43 (By similarity).  Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity).  Could also palmitoylate FYN as shown in vitro (PubMed:19956733).
What are the official names of this protein?
Palmitoyltransferase ZDHHC15, Acyltransferase ZDHHC15, Zinc finger DHHC domain-containing protein 15, DHHC-15.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Postsynaptic density.
Protein: KAD_THEVB
Sequence: MRLILFGGPGSGKGTQAAILTTLLGIPHISTGDILRAERAAGTLLGQQAQSYMDRGELVPDQVIVDMVANRLQQPDTAAGWLLDGFPRNGAQAAVFEEMLKSIHQDYDYLLFLDVPAAILQERALNRAKQAVNGQQRSDDTPETILKRLQVYERETLPMIQQYMSHPKFVPIDGTRTIEEVTAAIQARIGEVNRV
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_LYSSC
Sequence: MSKTVVRKNESLEDALRRFKRTVSKSGTIQEVRKREFYEKPSVKRKKKSEAARKRKW
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RR8_OLIPU
Sequence: MGKDTIADIITSIRNADMNRKGTVRIGSTNITESIVKILLREGFIENVRKHRESNQYFLILTLRHRRNKKESYKTILNLKRISRPGLRIYSNSQRIPRILGGIGIVILSTSQGIMTDREARLKRIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATPH_OEDCA
Sequence: MNPLIAASSVIAAGLAIGLAAIGPGVGQGTVAGNAVEGIARQPEAEGKIRGTLLLSFAFMESLTIYGLVVALALLFANPFVGA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CWC21_USTMA
Sequence: MYNGIGLKTARGTGTNGYVQRNLSNFEAGKKRWNKRDATDEVGSDTRLGPDAAILEHERKRAVEVKCMELRVELEDDDVADDEIEERVAQLRETLNAQLAEQTNESAASSYESGRAKETRLRHMGTHQQIQTKQHLDRRFAIAVGVESGYRQADAFNRDLQELKKSERIHQQRQAYQQRQLARASHASTQPPPHPPARCSSTHSQSTSSSSPSSPPRKRARSRSASQDSSARSSSSHASPRSPTPRTTSHVASYSSYSSRSRSRSRSRSPLSHSRSSRSRSRSRSRSRSRSRSPLSHSRSSRSRSPSRSRSPSRCASSRSRSPAHRPRRHSSSRVNPPGPPPRRPAGL
What is the function of this protein?
Involved in pre-mRNA splicing.  May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome.  May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CWC21.
What is the protein family that this protein belongs to?
Belongs to the CWC21 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PIP13_ARATH
Sequence: MEGKEEDVRVGANKFPERQPIGTSAQTDKDYKEPPPAPFFEPGELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVFYIVMQCLGAICGAGVVKGFQPNPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHAWDDHWIFWVGPFIGAALAALYHQLVIRAIPFKSRS
What is the function of this protein?
Water channel required to facilitate the transport of water across cell membrane.  Its function is impaired by Hg(2+).
What are the official names of this protein?
Aquaporin PIP1-3, AtPIP1;3, Plasma membrane intrinsic protein 1c, PIP1c, Transmembrane protein B, TMP-B.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SUN3_HUMAN
Sequence: MSGKTKARRAAMFFRRCSEDASGSASGNALLSEDENPDANGVTRSWKIILSTMLTLTFLLVGLLNHQWLKETDVPQKSRQLYAIIAEYGSRLYKYQARLRMPKEQLELLKKESQNLENNFRQILFLIEQIDVLKALLRDMKDGMDNNHNWNTHGDPVEDPDHTEEVSNLVNYVLKKLREDQVEMADYALKSAGASIIEAGTSESYKNNKAKLYWHGIGFLNHEMPPDIILQPDVYPGKCWAFPGSQGHTLIKLATKIIPTAVTMEHISEKVSPSGNISSAPKEFSVYGITKKCEGEEIFLGQFIYNKTGTTVQTFELQHAVSEYLLCVKLNIFSNWGHPKYTCLYRFRVHGTPGKHI
What is the function of this protein?
As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton.  The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.  May be involved in nuclear remodeling during sperm head formation in spermatogenesis.  A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
What are the official names of this protein?
SUN domain-containing protein 3, Sad1/unc-84 domain-containing protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Nucleus envelope. Nucleus inner membrane.
Protein: ATPI_STIHE
Sequence: MLNLQNVIINPLFEISEVSVGEHYYWEIAGYEVHGQVLLTSWFVLGTVILFGLIANKDLKPLPEGLQNFSELVTEFIRDLAKTQVGEEEYLKWVPFIGTIFIFVLVSNWSGALLPWRLIEIPNGELAAPTNDINTTVALALLTSISYFYAGIRKKGLGYFKRYVQPAVFLLPINVLEDFSKPLSLSFRLFGNILADELVVGVLVALVPLIVPIPVMLLGVFTSAIQALVFATLAGAYIGESVEDHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: LEUC_BURVG
Sequence: MAQTLYDKLWNTHVVHTEDDGTALLYIDRQLLHEVTSPQAFEGLNVAHRPVWRISANLAVSDHNVPTTDRSHGIADPVSKLQVDTLDANCDAFGITQFKMNDLRQGIVHIIGPEQGATLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLLQKKSKNMLVKVEGTLPRGCTAKDIVLAIIGKIGTAGGTGYAIEFGGSTIRALTMEGRMTVCNMAIEAGARAGMVAVDDTTIDYLKGRPFVPTGAEWDQAVEYWREFKSDEGAQFDRVVELNAAEIVPQVTWGTSPEMVTSIDARVPDPEREKDPVKREAMERALAYMALEPNTPMESINVDKIFIGSCTNARIEDIRAAAYVVKKLNRRIAPNVRLAMVVPGSGLVKAQAEREGLDKVFTDAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAIEGHFVDIRKLG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: EST3_KLULA
Sequence: MPNVVLSSRLTNNDSVFLQEWIKPSVRPYYLKNEKTKFWPEQRELVTDLLEHDIIESAFQTALNPAPQRFVRIVKFHRVNDYTVYATIRDSTALILCYFTVDCVLDYETINNDRITLNTLNTLFVIGNVTLQFWNHRECKLWFNQDFPGLRMVPVLKIEKARMFDRDQISSNVQFEWVYDTLHG
What is the function of this protein?
Component of the telomerase complex involved in telomere replication.  Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).
What are the official names of this protein?
Telomere replication protein EST3.
What is the protein family that this protein belongs to?
Belongs to the EST3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: GILX_HELHO
Sequence: IIGGQECDETGHPWLALLHRSEGSTCSGVLLNQDWIVTAAHCFYLGELRIGLGVHNRRVLRGNEQVRVSARKKCYPATASIITNSSCSEYTDDIMLIKLDSSVEYTERVRPLSLPTSPASEGAECTVMGWGTTTPPDVTYPAVPVCVRIEMLNNAVCELARDLWNITDSVLCAGTWFGGKDSCKGDSGGPLICRGQLTGIVSWGGFPCEQPLEYGVYTKVISFLFWIQSI
What is the function of this protein?
Has kallikrein-like activity, releases bradykinin from kininogen.  Catalyzes the hydrolysis of various arginine ester substrates for trypsin and thrombin and degrades both angiotensin I and II by cleavage of the dipeptide Asp-Arg from the NH2-terminal end.  Fibrinogen is also degraded but a fibrin clot is not produced.  May have a potentiating effect on potent hemorrhagic toxins present in the venom.
What are the official names of this protein?
Gilatoxin, GTX, Kallikrein-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1493_METJA
Sequence: MITMNYDPKIIERGKLYYRNNLVKYCIKYKNFLFGEVVGSDTYKVKVDLDNNYFGLCTCQYKYNCKHAYALIEAYENNNYVDAEEIFKEIEDKPKEEILKILKNLVVKYYLWDEFLNTDSLLNKAIGLIKLIPLERKNIYTFKSFLRNQFVKNADDEELIKVIDEMIRADLDFNNSDIIEALTIILDEIFRRENKEAIKKLINLYRKHKKELWIVGDYLIEYYDNYFDYED
What are the official names of this protein?
Uncharacterized protein MJ1493.
Protein: GAS1_MAGOR
Sequence: MSLKSLIAATILAAPLVAGHGAIIKAVGDAGGEGMGLGVVTSTPRDGTRRDPFQQDSTRFKGQQADTFGETVGGGQNDVESMTKAIMAETGSQLPQISPGGSLQMTLHQVNGDGAGPYTCELNDDASGAQWQQIRVTTTPPGRNSRNRDGAMTDFPLVAEIPQRQACTGTVAGQTNVCLVRCMNAARAGPFGGVVAAQLAGSQTPQAARRALAESVKRSELIVSGLKKRGYNIADLSQEEIDELRRDGEIA
What is the function of this protein?
Appressoria-specific virulence factor required for appressorial penetration in host and lesion development.
What are the official names of this protein?
Appressoria-specific virulence factor GAS1.
What are the subcellular locations of this protein?
Cytoplasm. Note=Exclusively located in the cytoplasm of appressoria cells.
Protein: ECOT2_TRYCC
Sequence: MSTAPKTLADYQAPYPEATPNQKRYVIFLEEKDYDSELEEYKLQLIPGRVMKVDPVNRCFIAGSVKEKTIPGWGYNYYVVEMGPMATTLMAVSPGSPPVRKFVPMAERPFIPYNSKLPVVVYMPKEGELHYRVWTPTKPKEEIAGER
What are the official names of this protein?
Ecotin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
Protein: SAP61_SCHPO
Sequence: MSESVLETERYAHEELERLQQAIVDRQVANPKAPRERLRLEHQSAQFLNQFRETSKKLLVSHESSDRLKDQEVARINADDDLTEFYKSLGEIQEFHKKYPDHKVEDLSQLYSIKPSQPGIDEIDTLFRGEEMYGRFMDLNECYEEYINLSNVQHISYLEYLKNLEDFDQIPKPEKNQTYINYITHLYEYLVSFYRRTHPLSNLDKIIAVFDTEFDAAWEAGLPGWYSHNAEAEKDGKDSTEAFYCEVCQKFFGKITVFEAHKKSKAHNKAVKRMQSSSPSTTSNTNEKQKGPKAIARIEFLIKKLTSLLDDVRKDTRENVVRRQTLTAAERLAEVEAAEREAFEQSTPSVSVEGNQDEESDQDDEEKIYNPLKLPLGWDGKPIPFWLWKLHGLGKEFPCEICGNYVYMGRKAFDKHFTEQRHIYGLKCLGISPSPLFNQITSIDEALQLWQKYKVDSKKRETTMASLNEMEDDEGNVMSEKVYNDLKAQGLL
What is the function of this protein?
Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
What are the official names of this protein?
Pre-mRNA-splicing factor sap61, Spliceosome-associated protein 61.
What is the protein family that this protein belongs to?
Belongs to the SF3A3 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: SYK_HELPH
Sequence: MFSNQYIQQRIHKANSLREEGKNPYQNGLKRSLTNAAFLEKYAYVKDLEEPKDKEKCESIVGRVKLLRLMGKACFIKVEDESAILQAYVSQNELNDEFKSLKKHLEVGDIVLVKGFPFATKTGELSVHALEFHILSKTIVPLPEKFHGLSDIELRYRQRYLDLIVNPGVKDVFKKRSLIVSSVRKFFEMEGFLEVETPMMHPIPGGANARPFITYHNALEVERYLRIAPELYLKRLIVGGFEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLKTLNLPSKIIYNDMEVDFNQTSVISYLDALETIGGISKDILEKEDRLLAYLLEQGIKVEPNLTYGKLLAEAFDHFVEHQLINPTFVTQYPIEISPLARRNDSNPNIADRFELFIAGKEIANGFSELNDPLDQLERFKNQVAEKEKGDEEAQYMDEDYVWALAHGMPPTAGQGIGIDRLVMLLTGAKSIKDVILFPAMRPVKNDFNIESGE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_MAGSA
Sequence: MADPRFFRVAGPFTLAQLAELSGASVAEGCDLGASFVDVAPLEQAGQDNVSFLDNRKYVGAFQASKAGLCVIAPEMADKAPEGMALLLSPDPYRAYARIAQAFYPNPAPEPWVAPTAWVDASAAVGEGCRIEPGAVIGAGARIGARCRIGANVVIGQGVVLGDDCTIGANATVSHALVGSRVNIYPGARIGQDGFGFAMGPQGHLKVPQLGRVLIGNNVEIGANTTIDRGAGPDTVIGDGSMIDNLVQIGHNVQLGRGCVIVAQVGISGSTRMGDFVAAGGQAGITGHLKIGAGAKIAAQAGVMRDIAPGETVGGAPAVPMADWLRQSAILGKMARKKS
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: IMH1_YEAST
Sequence: MFKQLSQIGKNLTDELAKGLADDMSPTPSEQQIEDDKSGLPKEIQAKLRKFEKYEQKYPLLLSAYKNEKLKSEKLEAVEKILAENTPISNIDDAVDTLPAFFQDLNNKNNLLNDEIKRLTKQNSEIPESASSETLKDKEEEFLKKEQNYKNDIDDLKKKMEALNIELDTVQKEKNDTVSGLREKIVALENILKEEREAKKQKEEVSISELKEELAIKNHSLEDSRMKITELEQNLSSKSTIMEEKSSELAELNITLKEKERKLSELEKKMKELPKAISHQNVGNNNRRKKNRNKGKKNKGGITTGDISEEETVDNSINTEEYDKLKENLQELQEKYKDCEDWKQKYEDIEAELKDAKELENSQLEKSAKELETLNTELIDTKKSLKEKNSELEEVRDMLRTVGNELVDAKDEIKESSSKQNEEVKTVKLELDDLRHKNATMIEAYEAKNTELRSKIELLSKKVEHLKNLCTEKEKEQTTSQNKVAKLNEEISQLTYEKSNITKELTSLRTSYKQKEKTVSYLEEQVKQFSEQKDVAEKSTEQLRKDHAKISNRLDLLKKENETLHNDIAKNSNSYEEYLKENGKLSERLNILQEKYNTLQNVKSNSNEHIDSIKRQCEELNVKLKESTKKILSLEDELNEYANIVQDKTREANTLRRLVSDSQTDDSSKQKELENKLAYLTDEKNKLEAELDLQTSRKATELQEWKHTVTELKSEIHALKLREEGLKSEVDALKHVNNDIKRKTQATSDDSDQLEQITSNLKLSLSKADEKNFELQSANEKLLNLNNELNKKFDRLLKNYRSLSSQLNALKERQYSDKSGRVSRSGSIGTLANANIDSSPANNSNPTKLEKIRSSSSLELDSEKNEKIAYIKNVLLGFLEHKEQRNQLLPVISMLLQLDSTDEKRLVMSLK
What is the function of this protein?
Involved in vesicular transport between an endosomal compartment and the Golgi apparatus.
What are the official names of this protein?
Golgin IMH1, Integrins and myosins homology protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=IMH1 is recruited to the Golgi apparatus by ARL1.
Protein: SMTB_MYCTO
Sequence: MVTSPSTPTAAHEDVGADEVGGHQHPADRFAECPTFPAPPPREILDAAGELLRALAAPVRIAIVLQLRESQRCVHELVDALHVPQPLVSQHLKILKAAGVVTGERSGREVLYRLADHHLAHIVLDAVAHAGEDAI
What is the function of this protein?
Transcriptional regulator involved in zinc homeostasis.  Represses the expression of the smtB-zur operon in the absence of zinc.  Could act as the metal sensor that controls the expression of zur in response to zinc availability (By similarity).
What are the official names of this protein?
HTH-type transcriptional repressor SmtB.
Protein: LEUC_BACVZ
Sequence: MMPRTIIEKIWDRHVVKSGEGKPDLLYIDLHLIHEVTSPQAFEGLRQKGRKVRRPQNTFATMDHNIPTVNRFDIKDEVAKRQVTALERNCEEFGVRLADLHSADQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQQRPKTLEIRVDGTLQKGVTAKDVILSVIGKYGVKFGTGYVIEYTGEVFRNMSMDERMTVCNMSIEAGARAGLIAPDDTTIEYCKNRKYAPKGEEFEKAAAEWKALKTDPGAVYDHSIVLDGSEISPMVTWGVNPGMVLPVDAQIPAPETIDSEDGKKEAIRAYEYMGISPNQKIEDIKVEHVFIGSCTNSRMTDLRQAADMIKGRKVADSVRAIVVPGSQSVKQQAEEEGLHRVFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMAAMAAIHGHFVDVRKFYQEKTVV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: STML3_HUMAN
Sequence: MDSRVSSPEKQDKENFVGVNNKRLGVCGWILFSLSFLLVIITFPISIWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILAGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAESPIALQLRYLQTLSTVATEKNSTIVFPLPMNILEGIGGVSYDNHKKLPNKA
What is the function of this protein?
Required for the function of many mechanoreceptors.  Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins.  Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.
What are the official names of this protein?
Stomatin-like protein 3, SLP-3.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein. Note=Detected in lipid rafts.
Protein: PCSK6_HUMAN
Sequence: MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG
What is the function of this protein?
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif.  Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 6, Paired basic amino acid cleaving enzyme 4, Subtilisin-like proprotein convertase 4, SPC4, Subtilisin/kexin-like protease PACE4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
[Isoform PACE4A-I]: Secreted. SUBCELLULAR LOCATION: [Isoform PACE4A-II]: Secreted. SUBCELLULAR LOCATION: [Isoform PACE4C]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum. SUBCELLULAR LOCATION: [Isoform PACE4CS]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum. SUBCELLULAR LOCATION: [Isoform PACE4E-I]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus. SUBCELLULAR LOCATION: [Isoform PACE4E-II]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus. SUBCELLULAR LOCATION: [Isoform PACE4B]: Secreted.
Protein: CAY1_CONIM
Sequence: MGMRMMFTVFLLVVLATTVVPITLASATDGRNAAANARVSPVISKSSKKWCHPNPYTVG
What is the function of this protein?
Acts as a neurotoxin.
What are the official names of this protein?
Putative conotoxin.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMB_SALHS
Sequence: MKKQNNLRSLAAQAVEQVVEQGQSLSNVLPPLQQKVADKDKALLQELCFGVLRTLSQLEWLINKLMSRPMTGKQRTVHYLIMVGFYQLLYTRVPPHAALAETVEGAVSIKRPQLKGLINGVLRQFQRQQETLLNEFATSDARFLHPGWLVKRLQNAYPTQWQHIIEANNQRPPMWLRVNRTHHTRDGWLGLLEDAGMKGYPHPDYPDAVRLETPAPVHALPGFAEGWVTVQDASAQGCAVFLAPQNGEHILDLCAAPGGKTTHILEVAPEADVLAVDIDEQRLSRVYDNLKRLGMKATVKQGDGRYPAQWCGEQQFDRILLDAPCSATGVIRRHPDIKWLRRDRDIAELAQLQAEILDAVWPRLKPGGTLVYATCSVLPEENRDQIKTFLQRTPDAALSETGTPDQPGQQNLPGGEEGDGFFYAKLIKK
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.