PharMolix/UniProtQA huggingface dataset:
Protein: SLU7_DEBHA
Sequence: MSSQEKHKPEYDSSGKEVNPYIPKFISAVPWYHNKSNDEKSDDYLSHQRSNVADEAKDHSIPQPGSGINDEFEIKGETEIKKVEDYDSKRDRWHGYEAQEWDKIAENWDKIKKKKQKTKNASVEEDSDDTDYELELVELGLDSKDIKNNLKEDPLEKTIRDRQDVPAYILNITSSNKIHYDPKSRLTKDPSKGFINDKNQFVKKLTGEAKRLDNLQKFAWEQNRQQEEMKQREAFEQKLTGKKHSEGGPDEYQVDLNLNMEANPTAMMLQARHKQEQQQASHDQKKSDLVAKYGGGEFLNKSKEFVNVTESIQTGDKPINKDKNGLKRSIYPEDNYSMNHQSIWGSYYSGGQWGYCCCKQTTRNSRCTLN
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor SLU7.
What is the protein family that this protein belongs to?
Belongs to the SLU7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CP138_MYCBO
Sequence: MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVRRYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVIDKLIEAERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLGWAFERLSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTLETTTAAGERSHGRGVAFTPKDGGRVVMRRR
What are the official names of this protein?
Putative cytochrome P450 138.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: YCDX_ECOBW
Sequence: MYPVDLHMHTVASTHAYSTLSDYIAQAKQKGIKLFAITDHGPDMEDAPHHWHFINMRIWPRVVDGVGILRGIEANIKNVDGEIDCSGKMFDSLDLIIAGFHEPVFAPHDKATNTQAMIATIASGNVHIISHPGNPKYEIDVKAVAEAAAKHQVALEINNSSFLHSRKGSEDNCREVAAAVRDAGGWVALGSDSHTAFTMGEFEECLKILDAVDFPPERILNVSPRRLLNFLESRGMAPIAEFADL
What are the official names of this protein?
Probable phosphatase YcdX.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: PATI_PENEN
Sequence: MDILQLAPTHLLAILLSSTSALFLITYLLRAGHRPSDLPNGPPTVPLFGNELQVPKSDAHFQFSRWAKEYGGFFTLKRYNNTTIVISDQKLIKTLLDKKSNIYSHRPASLVSHLITQSDHLLVMQYGERWRMLRKTIHQYFMEPRCERDHWKVQEAEAKQMLHDYLTMPEDHMLHPKRYSNSITNSLVFGIRTKTVHDEYMKKLFYLMDKWSLVQELGATPPVDSFALLRYVPQWMLGNWRNRAVEVGDLMQSLYQTVLDQVKERRQRGIQRDSFMDRVLDTLKQTPLSENELRFLGGVLMEGGSDTSSSLILTIIQAMTKYPEVQAKAHAQIDSIIGHNRSPAWSDWSKLPYINMIIKESHRWRPVSPLGVPHAVAEDDHIDGKLIPQGSSIVLNVWGMHHDSDRWQEPEHFQPERFADFPALASGYAGSERRDHLGYGAGRRICPGIHLAERNLIIGIAKLLWAFEFLEPLGSDSDISAHSGASKGFLHCPKDYGCVIRLRSPEKRETIMREFAEAQEVFARFD
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:30100914, PubMed:25625822, PubMed:30680886).  PatI catalyzes the conversion of m-hydroxybenzyl alcohol into gentisyl alcohol (PubMed:30680886).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units.  The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol).  These first reactions occur in the cytosol.  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI.  The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole.  PatN catalyzes then the transformation of isoepoxydon into phyllostine.  The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol.  The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM.  Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (PubMed:30680886) (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase patI, Patulin biosynthesis cluster protein I, m-hydroxybenzyl alcohol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: IOLJ_ALKCK
Sequence: MGFVPMAPLLADAKKDSYAIGQFNINGLQWAKAILAGAESQQSPVIAAASDRLIDYLGGFQTVVAMMGALTDELGITVPVVLHLDHGLSIERCKKAVDAGFSSVMFDGSHYPINENIDMTKEVVAYAHAHNVSVEGEVGTVGGMEDGLMAEIKYADVEECQRFVCETNVDALAAALGSVHGKYKGEPKLGFNEMAAISASTNVPLVLHGASGIPDEQLQRAIKLGHAKININTECMIAWSDACRTTFAEQETAFEPRLLLQEGLAMVQATVEKKIKQFGAANKAAGSASLQRR
What is the function of this protein?
Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).
What are the official names of this protein?
6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase, DKGP aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. IolJ subfamily.
Protein: FHUG_BACSU
Sequence: MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFFGQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSLAVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGIGVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYKARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVARRLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMKAN
What is the function of this protein?
Part of the ABC transporter complex FhuBGCD involved in iron(3+)-hydroxamate import.  Responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Iron(3+)-hydroxamate import system permease protein FhuG, Ferric hydroxamate uptake protein G, Ferrichrome transport system permease protein FhuG, Iron(III)-hydroxamate import system permease protein FhuG.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VL2_HPV62
Sequence: MPKVLHRRKRASATDLYRTCKVSGTCPSDVIPKVEGNTLADKILKWASLGVFFGGLGIGTASGTGGRTGYIPIGGRPPSVVDIGPVSRPPVVIEPVGATDPSIVTLVEDSSIIEAGAVHPNFTGSSGFEVTTSSTATPAVLDISPTGTTVQVSSTNFLNPAYTEPSIIDPPQTGELSGHVLTSTPTAGSHSYEEIPMVTFASNAGTGSEPISSTPLPGVRRVAGPRLGLYTKATQQVPVADPAFVSRPASFATFDNPIYDPEETIIFEHPSIYTPPDPDFLDIVTLHRPALTSRQGTVRLSRVGQRASLRTRSGKRIGARVHFYHDISPIPSTTTGDIELQPLLPSGSSSADTLYDVYADDQHLDAVLQSVPSMSSRPLVPSNATISATSVASSHTNVTVPLSTGLSVPASTGPDVELPQFSVPVSVLTPSFPATTPYSIYIVGSDYYLFPSYIFFPKKHKRLHYFFTDGYVAAW
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: FOLD_YERPS
Sequence: MSAKIIDGKTIAQQVRNEVAAVVQQRLAAGKRAPGLAVVLVGENPASQIYVASKRKACEEVGFVSRSYDLPMATSEAELLALIDSLNEDTEIDGILIQLPLPNGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPKLRACTPRGIMTLLERYDIPTYGLNAVVVGASNIVGRPMSLELLLAGCTTTVTHRFTKNLRHHIENADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLESGKVVGDVAFDVAAERAGWITPVPGGVGPMTVATLIQNTLQACEEYHDISQN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RT16_DROME
Sequence: MSLSPASGIGRFYAKSAKIIRFVRLGCTNRPFYHIVVMERRKNQHQPVIEQVGSFDPLPNDYNERLVALNTERIRYWLGKGAHLSTPAAELLGIAGLLPIHPRTYMTAWRNRRTAAEAEASPEKAESTA
What are the official names of this protein?
Probable 28S ribosomal protein S16, mitochondrial, MRP-S16, S16mt.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NUDT8_MOUSE
Sequence: MLPDGLSAEDEQRCRQLLARTTARLRSRPAAAAVLVPLCLVRGVPALLYTLRSSRLVGRHKGEVSFPGGKCDPDDQDVIHTALRETQEELGLEVPKEHVWGVLQPVYDREKATIVPVLANVGPLDLQSLRPNLEEVDEVFEMSLAHLLQTQNQGYTHFCQGGHFSYTLPVFLHGPHRVWGLTAVITELTLKLLAPGFYQPSLAVPELPRG
What is the function of this protein?
Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (PubMed:31004344).  Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (PubMed:31004344).  Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673).
What are the official names of this protein?
Mitochondrial coenzyme A diphosphatase NUDT8, Nucleoside diphosphate-linked moiety X motif 8, Nudix motif 8.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DDL_FRATH
Sequence: MKNEKIVVLYGGDSPEREVSLKSGKAVLDSLISQGYDAVGVDASGKELVAKLLELKPDKCFVALHGEDGENGRVSALLEMLEIKHTSSSMKSSVITMDKMISKEILMHHRMPTPMAKFLTDKLVAEDEISFPAAVKPSSGGSSIATFKVKSIQELKHAYEEASKYGEVMIEQWVTGKEITVAIVNDEVYSSVWIEPQNEFYDYESKYSGKSIYHSPSGLCEQKELEVRQLAKKAYDLLGCSGHARVDFIYDDRGNFYIMEINSSPGMTDNSLSPKSAAAEGVDFDSFVKRIIEQAQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIG4_CLAP2
Sequence: MPAPVEIQQATLSKFIDAWKRWNADDFIGLWSDSFTFQVLPFSDGKPTRPRDMIAPMYRNFIETLTNYKAIFIAFSESGDKIERLEEVNDNAFRKEWDPKCHAYWGYGQPPKAKAVAGS
What is the function of this protein?
Part of the ergochrome gene cluster responsible for the typical purple-black color of the ergot sclerotia (PubMed:28955461).  The ergochrome gene cluster produces several ergot pigments including the yellow ergochrome secalonic acid and its derivatives, as well as the red anthraquinones endocrocin and clavorubin (PubMed:28955461).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) CPUR_05437 (By similarity).  The atrochrysone carboxyl ACP thioesterase CPUR_05436 then breaks the thioester bond and releases the atrochrysone carboxylic acid from CPUR_05437 (By similarity).  The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone (By similarity).  The next step is performed by the anthrone oxygenase CPUR_05434 that catalyzes the oxidation of emodinanthrone to emodin (By similarity).  Emodin is further modified to yield monodictyphenone via several steps involving CPUR_05427, CPUR_05428, CPUR_05429 and CPUR_05430 (By similarity).  The short chain dehydrogenase/reductase CPUR_05418 then catalyzes the C-5 ketoreduction to give the xanthone skeleton of the monomeric units (PubMed:32105084).  Ergochromes formation requires further dimerization steps of different xanthone units, probably catalyzed by the cytochrome P450 monooxygenase CPUR_05419 (PubMed:28955461).  CPUR_05425, CPUR_05426 and CPUR_05431 are unique to Claviceps, thus it is likely that they are involved in further modification of xanthone units or in their dimerization (PubMed:28955461).  The yellow ergochromes and the red anthraquinone pigments endocrocin and clavorubin are products from the same PKS derived precursors and the latter are likely shunt products in the pathway of xanthone biosynthesis (PubMed:28955461).  It is proposed that atrochrysone carboxylic acid released from the PKS CPUR_05437 can also be converted to endocrocin anthrone which is further oxidized into endocrocin by CPUR_05435 (By similarity).  Endocrocin could be then modified to clavorubin, possibly by CPUR_05423 and CPUR_05431 (PubMed:28955461).  Clavorubin is the principal anthraquinone metabolite produced by the cluster with a much higher yield compared to endocrocin (PubMed:28955461).
What are the official names of this protein?
Ergochrome gene cluster protein CPUR_05426.
Protein: PSBB_LOLPR
Sequence: MGLPWYRVHTVVLNDPGRLLAVHIMHTALVSGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITDSWGGWSISGGTVTNPGIWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLAIFSDDRTGKPSLDLPKIFGIHLFLAGVACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQAVNPAWGAEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSNGLAENLSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPVFRDKEGRELFVRRMPTFFETFPVVLVDEEGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRSQLGEIFELDRATLKSDGVFRSSPRGWFTFGHATFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGTFQKVGDPTTRKQAV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SDCF_EMENI
Sequence: MATVSELCCAALNTSIGNRIAFPGSTAYNESLSSYFGVNAQLPPSCFVLPLSAQDVSVAVQTLTSQPDPCFFAIRSGGHTTSLGASAIEAGVTMDLSGMNTTTYDSSTNTAFIQPGARWGSVYETLLRDNVLVPGGRTASVGVGGYLTGGRNSFHAARVGLACLSIKGYEIVLADGEVAKVDQDSHPNLFRALKGGSNNFGIVTLFDMEAFSTEGTIWGGTVLYDISTKDQYIAAGTAFTDNIPNDPYASWVGMFAYNSTTDQTAIFTSLAYTRPVQSWPQAFSEFYAIPNITHTLRSATVLDLAVENSFPYGYRNVLQTGTYSNNAEIIQKAVIILNNQVKMAKLRARGKDYALFAIVQPWVPLFWEHSEARGGDVLGLERFETNLLNIAWDYSWDNSADDELLYELAQSAREQLDEYARSTGAYNEYIYLNYAGRTQDPLRGYGLENLEFLRRVSEKFDPDGVFQRLVRGGFKIDRA
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the polyenes aspernidgulenes (PubMed:30302871).  The carbon backbone of aspernidgulenes is synthesized by the HR-PKS sdgA, which accepts acetyl-CoA as the starter unit and performs malonyl-CoA extensions as well as regioselective methylation and reduction (PubMed:30302871).  The resulting nonaketide offloads the HR-PKS by intramolecular lactonization to yield the 5,6-dihydro-alpha-pyrone-containing hexaenoic acids preaspernidgulene A1 and A2 (PubMed:30302871).  The FAD-dependent monooxygenase sdgC then installs the first epoxide on the penultimate double bond (PubMed:30302871).  Subsequently, the FAD-dependent monooxygenase sdgF presumably generates a ketone intermediate through Meinwald rearrangement involving a hydride shift (PubMed:30302871).  Next, sdgC introduces another epoxide on the last olefin of the ketone intermediate after E/Z isomerization (PubMed:30302871).  The epoxide hydrolase sdgD then catalyzes stereospecific cyclization of the 5,6-dihydro-alpha-pyrone and opening of the epoxide ring to form an oxygenated trimethylcyclopentanone and an oxabicyclo[2. 2. 1]heptane unit (PubMed:30302871).  Finally, the bicyclic unit undergoes hydrolytic cleavage, either spontaneously or catalyzed by sdgD, to assemble the dimethyl-gamma-lactone moiety in aspernidgulene A1 (PubMed:30302871).
What are the official names of this protein?
FAD-dependent monooxygenase sdcF, Aspernidgulenes biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: FHI2B_XENTR
Sequence: MWGRLGAFLQQAVETREPTQDLLQSFIQHWKGVTQYYLETSDESCPARETDIPWRLRQLIDILVFEESNNGSQLSSGDEEDSGAGSHAGPCMEYLLQHKILETLCTLAKAEYPPGMRQQVLLFYSRLLAKVQRPLLHYLSVHRPVQKLIALAEDPVGATAQKEELQFLTAVCTKLEKDPSLLVHVLEEGSGSRVRCSGGEQDGETEARNHKPRQNLFKALLRLCTCQKGRLCVRAREALLRVLHSAQQEGPVHLIVQSKLSQYVTEHLCELHRCIPLSIHPCDITALQETDWRKDSGSQESDGMENAEAALQRFLCWVEYCDCLVRESHEVVAMEITRSIKEGYLQGILQPELLEVSELSILRSTAILTAVLHRFTATPLLRQFLTFLFGDERGPETRGDRGSQLRSQLIQRCNHLSDEISLASLRLFEEILQMPEEIALHSLVIRNLETRSYLAGGQDESRGQESETWDGAEELEEDPYFTDGFPDTGIRLPRSDNAHRTEPAGTEQWVKSFLSLVPEEIKSSDTGYDGYLQDAIVQYRACCQQVAQWGWPVSSKGTGHSQQEFYEGHFMEVLLGRLGGILDQPYDVNLQVTSLLSRLALFPHPNLQEYLLNPFITLAPGARSLFSVLVRVVADLAQRSLRVPDLQEMLLLVRRQLLANSANEQLNHVTLCRGAVVLEEFCKELAAAACVTHSPVGF
What are the official names of this protein?
FHF complex subunit HOOK-interacting protein 2B, FHIP2B.
What is the protein family that this protein belongs to?
Belongs to the FHIP family.
Protein: RL20_PROA2
Sequence: MPRSKNAVASRARKKRILNKAKGYWGSRGTILTVAKHAVDKAEQYAYRDRRVKKRTFRALWIMRINAAARLNGTSYSRLMEAMHKKNIDINRKALAEIAVKDPSAFSQIVKTAMD
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ATPB_ECO8A
Sequence: MATGKIVQVIGAVVDVEFPQDAVPRVYDALEVQNGNERLVLEVQQQLGGGIVRTIAMGSSDGLRRGLDVKDLEHPIEVPVGKATLGRIMNVLGEPVDMKGEIGEEERWAIHRAAPSYEELSNSQELLETGIKVIDLMCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMTDSNVIDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIASLGIYPAVDPLDSTSRQLDPLVVGQEHYDTARGVQSILQRYQELKDIIAILGMDELSEEDKLVVARARKIQRFLSQPFFVAEVFTGSPGKYVSLKDTIRGFKGIMEGEYDHLPEQAFYMVGSIEEAVEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HEM3_DESOH
Sequence: MEIRIGSRKSSLAMWQTCYVEDKLKQSGITTSILPIDTRGDQVLNVAIAKIGSKGVFTEELEAKLADGDIDIAVHSAKDMPSVLPDGFELIAFTDREEPADVLVSHKKDLDISDSSRPVTIGTSSVRRQALLGRFYPHVRTVDIRGNVQTRVLKMKEGLCDAILMAYAGIHRMGMDDLIVHTFSPDTFIPPVGQGCIAVEASSRLAAEKKEAIRACINHPASETCLLAERAFLKRLEGGCSIPAFALARLNGDRLTLSGGLMSLDGKKFIFNTRAGAGSQATAIGTDLGNHVLENGGAALLAEIRKQQTT
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: ILVC_HELHP
Sequence: MALKVYYDKDCDLGLIQKKKVAVIGFGSQGHAHAENLRDSGVEVIIGLYRGGSSWVKAEAKGFKVLEVSEATKVADVIMILIPDELQADVFAKDILPSLSEDKIIAFGHGFNIHFGQIKAPKGVGVIMVAPKAPGHTVRSEFVKGGGIPDLIAVEQDTSRGDAKAIALSYASAIGGGRSGIIETTFKDETETDLFGEQAVLCGGVTSLVKAGFETLVEAGYPEEMAYFECLHELKLIVDLIYEGGLANMRYSISNTAEYGDMVSGPRVINEESKKAMKQILKDIQEGRFAKDFILERKAGYARMNAERKNLANHKIEQVGGRLRAMMPWIGANKLVDKERN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: KCIP1_RAT
Sequence: MGAVMGTFSSLQTKQRRPSKDIAWWYYQYQRDKIEDDLEMTMVCHRPEGLEQLEAQTNFTKRELQVLYRGFKNECPSGVVNEETFKQIYAQFFPHGDASTYAHYLFNAFDTTQTGSVKFEDFVTALSILLRGTVHEKLRWTFNLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKEDTPRQHVDVFFQKMDKNKDGIVTLDEFLESCQEDDNIMRSLQLFQNVM
What is the function of this protein?
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:14980206).  Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:14980206).  Modulates KCND2/Kv4. 2 currents (PubMed:14980206).  In vitro, modulates KCND1/Kv4. 1 currents (By similarity).  Increases the presence of KCND2 at the cell surface (PubMed:14980206).
What are the official names of this protein?
Kv channel-interacting protein 1, KChIP1, A-type potassium channel modulatory protein 1, Potassium channel-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, dendrite.
Protein: RL5_THEP3
Sequence: MSRLREKYEKEVVPALMERFGYKNIMQVPKVEKVVINIGVGEAKENPKALEAAVDDLTMIAGQKPVITRAKRSIANFKIRKGMPIGVKVTLRGERMYEFMDKLFNIALPRVRDFKGVSPNSFDGRGNYALGIKEQLIFPEIDYDKIDKIRGMDIIIVTTAKTDEEAKGLLELLGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RL3_MYCUA
Sequence: MARKGILGTKLGMTQVFDENNKVVPVTVVKAGPNVVTRIRTPERDGYSAVQLAYGEISPRKVNKPVTGQYTAAGVNPRRHLAELRLDDAEAVTEYEVGQELTAEIFADGSYVDVTGTSKGKGFAGTMKRHGFSGQGASHGAQAVHRRPGSIGGCATPARVFKGTRMAGRMGNDRVTVQNLLVHKVDAEQSVLLIKGAVPGRTGGLVTVRSAIKRGEK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.