PharMolix/UniProtQA huggingface dataset:
Protein: ACFD_ECOH1
Sequence: MNKKFKYKKSLLAAILSATLLAGCDGGGSGSSSDTPPVDSGTGSLPEVKPDPTPNPEPTPEPTPDPEPTPEPIPDPEPTPEPEPEPVPTKTGYLTLGGSQRVTGATCNGESSDGFTFKPGEDVTCVAGNTTIATFNTQSEAARSLRAVEKVSFSLEDAQELAGSDDKKSNAVSLVTSSNSCPANTEQVCLTFSSVIESKRFDSLYKQIDLAPEEFKKLVNEEVENNAATDKAPSTHTSPVVPVTTPGTKPDLNASFVSANAEQFYQYQPTEIILSEGRLVDSQGYGVAGVNYYTNSGRGVTGENGEFSFSWGEAISFGIDTFELGSVRGNKSTIALTELGDEVRGANIDQLIHRYSTTGQNNTRVVPDDVRKVFAEYPNVINEIINLSLSNGATLGEGEQVVNLPNEFIEQFNTGQAKEIDTAICAKTDGCNEARWFSLTTRNVNDGQIQGVINKLWGVDTNYKSVSKFHVFHDSTNFYGSTGNARGQAVVNISNAAFPILMARNDKNYWLAFGEKRAWDKNELAYITEAPSIVRPENVTRETASFNLPFISLGQVGDGKLMVIGNPHYNSILRCPNGYSWNGGVNKDGQCTLNSDPDDMKNFMENVLRYLSNDRWLPDAKSSMTVGTNLETVYFKKHGQVLGNSAPFAFHKDFTGITVKPMTSYGNLNPDEVPLLILNGFEYVTQWGSDPYSIPLRADTSKPKLTQQDVTDLIAYMNKGGSVLIMENVMSNLKEESASGFVRLLDAAGLSMALNKSVVNNDPQGYPDRVRQRRSTPIWVYERYPAVDGKPPYTIDDTTKEVIWKYQQENKPDDKPKLEVASWQEEVEGKQVTQFAFIDEADHKTPESLAAAKQRILDAFPGLEVCKDSDYHYEVNCLEYRPGTDVPVTGGMYVPQYTQLDLSADTAKAMLQAADLGTNIQRLYQHELYFRTNGRQGERLNSVDLERLYQNMSVWLWNETKYRYEEGKEDELGFKTFTEFLNCYTNNAYVGTQCSAELKKSLIDNKMIYGEESSKAGMMNPSYPLNYMEKPLTRLMLGRSWWDLNIKVDVEKYPGVVNTNGETVTQNINLYSAPTKWFAGNMQSTGLWAPAQQEVSIESKSTVPVTVTVALADDLTGREKHEVSLNRPPRVTKTYDLKANDKVTFKVPYGGLIYIKGDSKEVQSADFTFTGVVKAPFYKDGKWQHDLNSPAPLGELESASFVYTTPKKNLNASNYTGGLEQFANDLDTFASSMNDFYGRDSEDGKHRMFTYKNLPGHKHRFANDVQISIGDAHSGYPVMNSSFSPNSTTLPTTPLNDWLIWHEVGHNAAETPLTVPGATEVANNVLALYMQDRYLGKMNRVADDITVAPEYLEESNGQAWARGGAGDRLLMYAQLKEWAEKNFDIKKWYPDGTPLPEFYSEREGMKGWNLFQLMHRKARGDEVSNDKFGGKNYCAESNGNAADTLMLCASWVAQTDLSEFFKKWNPGANAYQLPGASEMSFEGGVSQSAYNTLASLDLPKPEQGPETINQVTEHKMSAE
What is the function of this protein?
May be a substrate of the type II secretion system beta (T2SS-beta).
What are the official names of this protein?
Putative lipoprotein YghJ, Putative lipoprotein AcfD homolog.
What is the protein family that this protein belongs to?
To V.cholerae AcfD (VC_0845).
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: DPOL_HBVE3
Sequence: MPLSYQHFRRILLLDEEAGPLEEELPRLADEDLNRRVAEDLNLQLPNVSIPWTHKVGNFTGLYSSTIPVFNPNWKTPSFPDIHLHQDIINKCEQFVGPLTVNEKRRLNLVMPARFFPISTKYLPLEKGIKPYYPDNVVNHYFQTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELHHGAFLDGPSRMGEESFHHQSSGIFSRPPVGSSIQSKHQKSRLGPQSQQRPLDGSQQGRSGSIRAGVHSPTRRPFGVEPSGSRHAKNIASRSASCLHQSAVRKAAYPNHSTFERHSSSGHAVEFHNISPSSAGSQSKRPVFSCWWLQFRNSEPCSDYCLTHLVNLLEDWGPCTEHGKHHIRIPRTPARITGGVFLVDKNPHNTAESRLVVDFSQFSRGSSRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSSGLSRYVARLSSNSRIINHQYGTLPNLHDSCSRNLYVSLMLLFKTFGRKLHLYSHPIIMGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLYTSVTNFLLSLGIHLNPNKTKRWGYSLNFMGYVIGSWGSLPQEHIIMKIKDCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQSKQAFTFSPTYKAFLCKQYLNLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFMAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGIYRPLLRLPFQPSTGRTSLYAVSPSVPSHLPDRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: H2BS1_STRPU
Sequence: MPSQRSPTKRSPTKRSPQKGAGKGGKGSKRGGKARRRGGAAVRRRRRRRESYGIYIYKVLKQVHPDTGISSRGMSIMNSFVNDVFERVAAEASRLTKYNRRSTVSSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTTSR
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.1, sperm.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: FOLD_CUTAK
Sequence: MTAQKLDGKATAAAIKSELAERVAALRDQGVVPGLGTVLVGEDPASHQYVAGKHRDCAQVGIESIRVDLPADVTEEELAQKIRGLNANPHCTGYIVQLPLPRHIDTNWALNLIDPNKDADGLTPASLGRLVLNEPAPLPCTPRGIVELLTRHGIELPGANVCVVGRGTTVGRPLGLLLTRRSENCTVTLCHTGTRNLAEHTRQADIIIGAAGSPGLINADMIREGAVLVDVGVSRTPEGKIQGDFTADVWEKAAWVSPNPGGVGPMTRAMLLSNVVDRAERLTADPS
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: METE_STRP4
Sequence: MSTTIIGFPRLGEFRELKFTTEKYFRKEISEEELLAAAKDLRAKHWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPASVQNLDLSDLERYFALGRGYQGEKGDVRALPMKKWFNTNYHYIVPKFEKDTQVKLAGHKIFDEFQEAKELGLNTRPVLVGPFTFLQLSDFEEGVKADDFVDSLVAAYQEVFAKLAELGATRIQLDEAALVKDLTAEEKALFLNLYNKLLADKKGLEVLLQTYFGDVRDVYADLVNLPVDAIGLDFVEGKKTLELVKGGFPADKTLYVGIVNGKNIWRNNYEKSLAVLEQIPAENIVLTSSCSLLHVPFTTANEEFEPALLNHFAFAVEKLDEIRDLDAIRNGQGSEALAANKELFATERVGENAELRARIAGLTDVDYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAYRKGELSQKEYDAFLAETIDEWIKWQEDIDFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGMRGVKPPIIWGDVTRLNPITVKWSSYAQSRTNKPVKGMLTGPVTILNWSFPREDISIKDSTLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVHSTVASDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVGPGVYDIHSPRVPNEGEIDNTIEAILAKVPSKKVWINPDCGLKTRGIPETKESLIRLVEAAKAAREKL
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: RL16_PELPD
Sequence: MLLPKRVKHRKQMKGRMTGKPCRGISLSFGEFGLQATECGWLDSRQIEAARIAMTRYIKRGGKIWIRIFPDKPLTSKPAETRMGKGKGSPDSWVAVIKPGTILYEMEGVSEEVAREALRLAAHKLPVSTKFITRSENHEA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: MUTS_BACLD
Sequence: MAGYTPMIQQYLKIKAEYQDAFLFFRLGDFYEMFFEDAKKASQELEITLTSRDGGSSERIPMCGVPYHSCSSYIEQLIKKGYKVAICEQVEDPKSAKGVVKREVVQLITPGTVMDGKGIHENENNFIASVSKFQHTYGLAFSDLTTGENLVTAIERLDDVVSEIYSVGAREIVVSRNLDEKDVAMLKERCGATISFEDEQADEVPGIVNGLGSKELVDTFMRLYVYLKRTQKRSLDHLQNVQAYELEEAMKIDLYSKRNLELTETIRSKNKKGSLLWLLDETKTAMGGRLLKQWIDRPLIRKGQIEERQEIVETLIAHLFEREDLRERLKEVYDLERLAGRVAYGNVNARDLIQLKESLKQVPAIKQLVGSLDHPKAKARAEKIDPCGDLLNLLEDALYENPPLSLKEGNLIKDGYHAKLDEYRDASKNGKDWIARLEQQEREYTGIRSLKVGFNKVFGYYIEVTKANIHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNICELEYELFSELRSKVKEYIPRLQQLAKMMSELDVLQCFATISENRHYVKPEFSDDVVQVIDGRHPVVEKVMDSQSYVPNSCEMGKGRQMLLITGPNMSGKSTYMRQMALISILAQIGCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVHATKNSLILFDEIGRGTSTYDGMALAQAIIEYVHEHIGAKTLFSTHYHELTSLEEKLDDLKNVHVRAEEYEGKVVFLHQIKEGAADKSYGIHVAQLAELPDGLISRAKTILKELESGAKEAAPSTAPNMVKEAAEEAAATVADQPAQLSFFETDKPIEKETKLSKKEQAVLAEFKAMDLLDMTPIQVMNELYRLQKKLK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CAPSD_BPF1
Sequence: MKKSLVLKASVAVATLVPMLSFAAEGDDPAKAAFDSLQASATEYIGYAWAMVVVIVGATIGIKLFKKFTSKAS
What is the function of this protein?
Self assembles to form a helical capsid wrapping up the viral genomic DNA.  The capsid displays a filamentous structure with a length of 760-1950 nm and a width of 6-8 nm.  The virion assembly and budding take place at the host inner membrane (By similarity).
What are the official names of this protein?
Capsid protein G8P, Coat protein B, Gene 8 protein, G8P, Major coat protein.
What is the protein family that this protein belongs to?
Belongs to the inovirus capsid protein family.
What are the subcellular locations of this protein?
Virion. Host membrane; Single-pass type I membrane protein. Note=prior to assembly, the major capsid protein is found associated with the bacterial host inner membrane.
Protein: LPER_BACAN
Sequence: MTHSMRLRFPTLNQ
What is the function of this protein?
This peptide is involved in the control mechanism of the synthesis of the macrolide-lincosamide-streptogramin B resistance protein.  It acts as a transcriptional attenuator.
What are the official names of this protein?
Erythromycin resistance leader peptide, 23S rRNA methylase leader peptide.
Protein: RIHA_ECOHS
Sequence: MALPILLDCDPGHDDAIAIVLALASPELDVKAITSSAGNQTPEKTLRNVLRMLTLLNRTDIPVAGGAVKPLMRELIIADNVHGESGLDGPALPEPAFAPQNCTAVELMAKTLRESAEPITIVSTGPQTNVALLLNSHPELHSKIARIVIMGGAMGLGNWTPAAEFNIYVDPEAAEIVFQSGIPVVMAGLDVTHRAQIHVEDTERFRAIGNPVSTIVAELLDFFLEYHKDEKWGFVGAPLHDPCTIAWLLKPELFTTVERWVGVETQGKYTQGMTVVDYYYLTGNKPNATVMVDVDRQGFVDLLADRLKFYA
What is the function of this protein?
Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihA, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihA subfamily.
Protein: MK12_HUMAN
Sequence: MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL
What is the function of this protein?
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.  MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2.  Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each.  Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets.  Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.  Phosphorylates DLG1.  Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes.  This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment.  Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure.  MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle.  C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation.  MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability.  MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
What are the official names of this protein?
Mitogen-activated protein kinase 12, MAP kinase 12, MAPK 12, Extracellular signal-regulated kinase 6, ERK-6, Mitogen-activated protein kinase p38 gamma, MAP kinase p38 gamma, Stress-activated protein kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity).
Protein: LPXA_XANOM
Sequence: MRDQAPLIHPTAVIDPSAQLASDVRVGAFSLIGADVHIGAGTEVGPHCSIHGPTRIGRNNRFIGHAAIGGEPQDKKYAGERTELVIGDDNVIREFVTINRGTRGGGGITTVGNDNWMLAYTHVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAHQFCRIGAHAFLGMGALTNGDVPPFTMVGRESLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLTDAKLQLAEQAKSSDDVRGMLEFIEAAERSLLR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSGA_SALEN
Sequence: MKLLKVAAFAAIVVSGSALAGVVPQWGGGGNHNGGGNSSGPDSTLSIYQYGSANAALALQSDARKSETTITQSGYGNGADVGQGADNSTIELTQNGFRNNATIDQWNAKNSDITVGQYGGNNAALVNQTASDSSVMVRQVGFGNNATANQY
What is the function of this protein?
Curlin is the structural subunit of the curli.  Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius.  Curli can bind to fibronectin.
What are the official names of this protein?
Major curlin subunit, Fimbrin SEF17.
What is the protein family that this protein belongs to?
Belongs to the CsgA/CsgB family.
What are the subcellular locations of this protein?
Fimbrium. Note=Part of the curli surface structure.
Protein: CDK18_PONAB
Sequence: MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNEDLQLGPLGRDPLQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPRYLPQPLISHAPRLDTDGIQLLSSLLLYESKSRMSAEAALSHPYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF
What is the function of this protein?
May play a role in signal transduction cascades in terminally differentiated cells.
What are the official names of this protein?
Cyclin-dependent kinase 18, Cell division protein kinase 18, PCTAIRE-motif protein kinase 3, Serine/threonine-protein kinase PCTAIRE-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: ASB2_MOUSE
Sequence: MATEISTRGRQRAIGHEEYSLYSSLSEEELLQMAIEQSLADKTRGPTPAEASASSQTNHQPGHFHPWTRSPSSPENPPARAPLGLFQGVMQKYSSNLFKTSQMAAMDPVLKAIKEGDEEALKIMIQDGKNLAEPNKEGWLPLHEAAYYGQLGCLKVLQQAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVRYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEASKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDAVLEALLAARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPRPGRFHDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
What is the function of this protein?
Targets filamins FLNA and FLNB for proteasomal degradation (PubMed:23632887).  This leads to enhanced adhesion of hematopoietic cells to fibronectin (By similarity).  Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (PubMed:29374072).  Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (PubMed:23632887).  Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells (By similarity).
What are the official names of this protein?
Ankyrin repeat and SOCS box protein 2, ASB-2.
What is the protein family that this protein belongs to?
Belongs to the ankyrin SOCS box (ASB) family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, stress fiber. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to the Z line in cardiomyocytes.
Protein: RR11_CUSEX
Sequence: MAKSIPRISSRRNGPIGSGKTVRRIPKGVIHVQASFHNTIVAVTDVRGRVVSWSSAGTSGFKGTRRGTPFAAQTAATKAIRTVVDQGMLRAEVLIKGPGLGRDAALRAIRRSGILLTFVRDVTPMPHNGCRPPKKRRV
What are the official names of this protein?
Plastid 30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid.
Protein: COX1_AMICA
Sequence: QHLFWFFGHPEVYILILPGFGMVSHIVAYYAGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMVIAIPTGVKVFSWLATLHGGAIKWETPLLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLHPTWSKIHFGVMFV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NADD_RHIME
Sequence: MAVGLFGGSFNPPHDGHALVAETALRRLGLDQLWWMVTPGNPLKDRNHLAPLGERIAMSEKIARNPRIKVTAFEQALGQSYTARTLEVIRARNRDVRFVWVMGADNLKNFHRWQDWRKIVATFPIAVVDRPGSTLAYLSSPMARAFSSARVDEDDAGTLAFRRAPAWTFIHGPRSGLSSTALRSAKSG
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: TAL_CHLL3
Sequence: MKFFIDTANLDEIRAAESLGVLDGVTTNPSLIAKIVEDPASFTRKDFMDHIKRICEIVDGPVNAEVTTLDAASMVREGEELAAIHNNVVVKCPLTIDGLKAIRSLSEKGIRTNATLVFSPNQALLAAKAGAGYVSPFVGRLDDISTDGMALVGQIVEIYDNYGLMTEVIVASIRHPQHVVESALIGADIATIPYSVIRQLANHPLTDAGLKKFMEDAAVIKK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1453_AQUAE
Sequence: MKCVVYGSKSPVLHQALEEVKRKFLEEKILTDFDFMIISLNYKYPYENLHRDLVKIFDISSDAYFGFHSTETIEETEIHDGLAVCFIKFENRGRLKVYWDSGISDYMSNGLLQRLVEYLEENKNNLNVFFSAWEDKNLGLFIEDLGRILGQKGFYPNLVGGVSSGRKFNGELRTFQFYKGKVIKDGFGILTFENVEFTLGISLGFKPISPIYEVRKADNYKVYEVDSRVPFKRIVENFLTGLEKKIEYLWYCPIVLVEERRGIRKGAENL
What are the official names of this protein?
Uncharacterized protein aq_1453.
Protein: YCDX_ECOHS
Sequence: MYPVDLHMHTVASTHAYSTLSDYIAQAKQKGIKLFAITDHGPDMEDAPHHWHFINMRIWPRVVDGVGILRGIEANIKNVDGEIDCSGKMFDSLDLIIAGFHEPVFAPHDKATNTQAMIATIASGNVHIISHPGNPKYEIDVKAVAEAAAKHQVALEINNSSFLHSRKGSEDNCRAVAAAVRDAGGWVALGSDSHTAFTMGEFEECLKILDAVDFPPERILNVSPRRLLNFLESRGMAPIAEFADL
What are the official names of this protein?
Probable phosphatase YcdX.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: IHFB_SHELP
Sequence: MTKSELIEKLATRQSQLSAKEVESAIKEMLEQMATTLEGGDRIEIRGFGSFSLHYRAPRTGRNPKTGTSVELEGKYVPHFKPGKELRERVDAINS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: JIP1_DROME
Sequence: MADSEFEEFHRPIFEPHTIAGFGSGAGSKKNNPHAFYSLIPNDDLEDSHSSKSDGDGSDQEDGIGLVDHEPKMRQVEDDELGDGLKVTLSSDGSLDTNDSFNSHRHHPLNHQDAIGGFLGMDTSGLGGNSAPVTIGASTDLLAPNTAATRRRRKLPEIPKNKKSSILHLLGGSNFGSLADEFRNGGGGGIPPAVRSGQQRSFLSLKCGYLMDEDSSPDSERMQSLGDVDSGHSTAHSPNDFKSMSPQITSPVSQSPFPPPFGGVPFGQLEMLEATHRGLHKFVPRHHDEIELEIGDAIYVQKEAEDLWCEGVNLRTGRQGIFPSAYAVDLDYNEFDPTVQLVKKERYLLGYLGSVETLAHKGTGVVCQAVRKIVGEYGNSPTGQTCILEVSDQGLRMVDRSGPNQNKKDKKPCIDYFYSLKNVSFCAFHPRDHRFIGFITKHPTVQRFACHVFKGSESTRPVAEAVGRAFQRFYQKFIETAYPIEDIYIE
What is the function of this protein?
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.  May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
What are the official names of this protein?
JNK-interacting protein 1, JIP-1, APP-like-interacting protein 1, APLIP1, Protein eye developmental SP512.
What is the protein family that this protein belongs to?
Belongs to the JIP scaffold family.
What are the subcellular locations of this protein?
Cytoplasm.