PharMolix/UniProtQA huggingface dataset:
Protein: THSD1_HUMAN
Sequence: MKPMLKDFSNLLLVVLCDYVLGEAEYLLLREPGHVALSNDTVYVDFQYFDGANGTLRNVSVLLLEANTNQTVTTKYLLTNQSQGTLKFECFYFKEAGDYWFTMTPEATDNSTPFPWWEKSAFLKVEWPVFHVDLNRSAKAAEGTFQVGLFTSQPLCPFPVDKPNIVVDVIFTNSLPEARRNSRQPLEIRTSKRTELAQGQWVEFGCAPLGPEAYVTVVLKLLGRDSVITSTGPIDLAQKFGYKLVMVPELTCESGVEVTVLPPPCTFVQGVVTVFKEAPRYPGKRTIHLAENSLPLGERRTIFNCTLFDMGKNKYCFDFGISSRSHFSAKEECMLIQRNTETWGLWQPWSQCSATCGDGVRERRRVCLTSFPSSPVCPGMSLEASLCSLEECAAFQPSSPSPLQPQGPVKSNNIVTVTGISLCLFIIIATVLITLWRRFGRPAKCSTPARHNSIHSPSFRKNSDEENICELSEQRGSFSDGGDGPTGSPGDTGIPLTYRRSGPVPPEDDASGSESFQSNAQKIIPPLFSYRLAQQQLKEMKKKGLTETTKVYHVSQSPLTDTAIDAAPSAPLDLESPEEAAANKFRIKSPFPEQPAVSAGERPPSRLDLNVTQASCAISPSQTLIRKSQARHVGSRGGPSERSHARNAHFRRTASFHEARQARPFRERSMSTLTPRQAPAYSSRTRTCEQAEDRFRPQSRGAHLFPEKLEHFQEASGTRGPLNPLPKSYTLGQPLRKPDLGDHQAGLVAGIERTEPHRARRGPSPSHKSVSRKQSSPISPKDNYQRVSSLSPSQCRKDKCQSFPTHPEFAFYDNTSFGLTEAEQRMLDLPGYFGSNEEDETTSTLSVEKLVI
What is the function of this protein?
Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.
What are the official names of this protein?
Thrombospondin type-1 domain-containing protein 1, Transmembrane molecule with thrombospondin module.
What are the subcellular locations of this protein?
[Isoform 1]: Endosome membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Note=Localizes to nascent focal adhesions. SUBCELLULAR LOCATION: [Isoform 2]: Membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Protein: GCS2_SALAR
Sequence: MPLNDFHVSEPYTLGIELEMQVINPPGYDLSQDSSTLIDAVKPQLTAGEIKHDITESMLEMATGVCRDIDQVAAQLSAMQHVILQAASEHHLGICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCANGDDAIYLLHGLSHFVPHFIALSAASPYMQGSDTRFACARLNIFSAFPDNGPMPWVSNWQEFAGLFRRLSYTAMIDSIKDLHWDIRPSPDFGTVEVRVMDTPLTLDQAINMAGLIQATAHWLLTERPFKPQEQDYLLYKFNRFQACRYGLEGMLTDVYTGDRRRLADDTLRLLDNVTPSARKVGADSAIDALRLQVKKGGNEAQYMREFIADGGSLIGLVQKHCEIWAGQ
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: ZIPA_HAEIE
Sequence: MDLNTILIIVGIVALVALIVHGLWSNRREKSKYFDKANKFDRTSLTSRSHTQEEMAQPNNISPNTYVENGHTPIPQPTTEKVPSEAELIDYRQSDKSVDDIKISIPNTQPIYDMGNHRSEPIQPTQPQYDMPTANNVASMTLEQLEEQSRNIGFNGINSSSPELRVQLAELSHEEHQVDYNLSFNEPKAETTAQPKQTTGYIQLYLIPKSSEEFNGAKLVQALENLGFILGKDEMYHRHLDLSVASPVLFSVANLEQPGTFNAYNLAEFNTIGIVFFMQLPSPGNNLANLRMMMRAAHTLAEDLQGVILTEEQEIFDANAEQAYLARV
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: HEM1_MYCPA
Sequence: MSVLLFGVSHRSAPVSVLEQLSIDESDHGKIVDRVLQSPLVTEAMVLSTCNRVEVYAVVDAFHGGLAVIGQVLSDHSGMSMSDLTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYATAETNRTVGRVLHELAQRALSVGKRVHSETAIDAAGASVVSVALDMADRRLGGLAGKTAVLVGAGAMGALAAAHLSRAGIGQVHVLNRSLSRAQRLVRKIRETGVRADALPLEHLADALAGADVVVSCTGAVSPVVSLADVHHALAAAGRSAADETAHPLVICDLGMPRDVDPAVAGLPGVWVVDVDRVQHEPSAHAAAADVDAARTIVATEVAAYLAGQRMAEVTPTVTALRQRAADVVEAELLRLDNRLPGLDSAHREEVARTVRRVVDKLLHAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVAAGELPVIATGFDAGAPQQPTE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PAND_KOSOT
Sequence: MFRIMQKSKIHRATVTDKNLNYEGSITIDYRLMKLADIRENELVQVVNINNGERFETYVIKGEEGSGVIALNGAAARLAEIGDRVIIISYAIYNDDEYKPPKIVKVTEKNEPIEK
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAT_STRAW
Sequence: MSAATPPTERRVSARVGAISESATLAVDAKAKALKAAGRPVIGFGAGEPDFPTPDYIVQAAIEACSNPKYHRYTPAGGLPELKAAIAAKTLRDSGYEVDASQVLVTNGGKQAIYEAFAAILDPGDEVIVPAPYWTTYPESIRLAGGVPVDVVADETTGYRVSVEQLEAARTENTKVLLFVSPSNPTGAVYTREQIEEIGRWAAEKGLWVLTDEIYEHLVYGDAEFHSLPVVVPELADKCIVVNGVAKTYAMTGWRVGWVIGPKDVIKAATNLQSHATSNVSNVAQVAALAAVSGDLTAVAEMREAFDRRRKTIVRMLNEIGGVLCPEPEGAFYAYPSVKALLGKEIRGKRPQDTVELAALILEEAEVAVVPGEAFGTPGYLRLSYALGDEDLVEGVSRIQKLLSEAKD
What is the function of this protein?
Catalyzes the reversible conversion of aspartate and 2-oxoglutarate to glutamate and oxaloacetate (PubMed:24302739).  Does not have prephenate aminotransferase activity (PubMed:24302739).
What are the official names of this protein?
Aspartate aminotransferase, AAT, AspAT.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_CORK4
Sequence: MALSAAKKKEILSEFGLHETDTGSTEAQVALLTERIRQLTEHLREHKHDHHSRRGLMLLVGRRKRLLKYLAANNVDRYRNLIARLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RP18_VACCA
Sequence: MSSFVTNGYLPVTLEPHELTLDIKTNIRNAVYKTYLHREISGKMAKKIEIREDVELPLGEIVNNSVVINVPCVITYAYYHVGDIVRGTLNIEDESNVTIQCGDLICKLSRDSGTVSFSDSKYCFFRNGNAYDNGSEVTAVLMEAQQGIESSFVFLANIVDS
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:31835031).  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 18 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 18 kDa subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle.
Protein: Y1967_SHEAM
Sequence: MLLDAIEARIIGCLLEKEVTTPDQYPLSLNALTLACNQKSSRAPVMDLSETQVQAGIDELTKKRLVSEQSGFGSRVVKYKHRFCNTEFSDLQLSSAQVAVLSLLLLRGPQTPGELRTRAGRQHDFKDIAEVEATLTALASRETPLVVQLPREPGKRESRFSLTIVEATTGMTTHSVASQVDERDDSRIAALEERVAQLEARLDALLLQTH
What are the official names of this protein?
UPF0502 protein Sama_1967.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: PROQ_ECOL6
Sequence: MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVDRVAGEMNLSKTQLRSALRLYTSSWRYLYGVKPGATRVDLDGNPCGELDEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAAAAGEKEDAPRRERKPRPTTPRRKEGAERKPRSQKPVEKAPKTVKAPREEQHTPVSDISALTVGQALKVKAGQNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRVP2_NAJKA
Sequence: MIAFIVLLSLAAVLQQSSGTVDFASESSNKRENQKQIVDKHNALRRSVRPTARNMLQMEWNSNAAQNAKRWADRCSFAHSPPHLRTVGKIGCGENLFMSSQPYAWSRVIQSWYDENKKFVYGVGANPPGSVIGHYTQIVWYNSHLLGCGAAKCSSSKYLYVCQYCPAGNIIGSIATPYKSGPPCGDCPSACVNGLCTNPCKHHNVFSNCQSLAKQNACQTEWMKSKCAASCFCRTEII
What are the official names of this protein?
Cysteine-rich venom protein kaouthin-2, Cysteine-rich venom protein 23, CRVP-23k.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
Protein: RUVB_STRA5
Sequence: MTRFLDSDAMGDEELVERTLRPQYLREYIGQDKVKDQLKIFIEAAKLRDESLDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPAIEKSGDLVAILNDLEPGDVLFIDEIHRMPMAVEEVLYSAMEDFYIDIMIGAGETSRSVHLDLPPFTLIGATTRAGMLSNPLRARFGITGHMEYYEENDLTEIIERTADIFEMKITYEAASELARRSRGTPRIANRLLKRVRDYAQIMGDGLIDDNITDKALTMLDVDHEGLDYVDQKILRTMIEMYNGGPVGLGTLSVNIAEERDTVEDMYEPYLIQKGFIMRTRTGRVATVKAYEHLGYQRFDK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: KDUI_YERPA
Sequence: MQVRQSIHSDHAKQLDTAGLRREFLIEKIFAADDYTMTYSHIDRIIVGGILPVSKAVSIGNEVGKQLGVSYFLERRELGAINIGGPGLIVVDGQTYDIGNEEALYVGKGAKEVKFSSIDRANPAKFYYNSAPAHTTYPNKKITLAEASPQTLGDDATSNRRTINKYIVPDVLPTCQLSMGLTKLAPGSLWNTMPCHTHERRMEVYFYFDMDEETAVFHMMGQPQETRHLLVHNEQAVISPSWSIHSGVGTKRYTFIWGMVGENQVFGDMDHIAVSELR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: THII_STRGC
Sequence: MHYSEIMVRYGELSTKGKNRMRFINKLKRNIQSVLSIYPQVHVKADRDRTHIYLHGTDYQPVAESLKQIFGIQNFSPSYRVKKSVPALIEAVQTIMKQVYQEGMTFKITSKRSDHSFELDSRELNQTLGDAVFMAIPNVQVKMKAPDIELRVEIREEAAYISYETIRGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGVDIEAVHFASPPYTSPGALKKAQDLTRKLTKFGGNIQFIEVPFTDIQEEIKAKAPEAYLMTLTRRFMMRITDRIREERGAQVIINGESLGQVASQTIESMQAINAVTNTPVIRPVVTMDKLEIIEIAEKIDTFQISIQPFEDCCTIFAPDRPKTNPKIKNAEQYEARLDVEGLVERAVAGIMITEIRPQAETDEVDELIEGLL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSP2_PROEL
Sequence: VIGGDECNINEHPFLVLVYYDEYQCGGTLINEEWVLTAAHCDGENMEIHLGMHSKKVPNKDRRRRVPKEKFFCDSSKNYTKWNKDIMLIRLNRPVRKSAHIAPLSLPSSPPSVGSVCRIMGWGTISPTEETYPDVPHCANINLLDYEVCRAAYPELPATSRTLCAGILEGGKDSCGGDSGGPLICNGQFQGIVSWGGDPCAQPHEPGSYTNVFDHLDWIKGIIAGNTDATCPL
What is the function of this protein?
Thrombin-like snake venom serine protease that clots rabbit fibrinogen.  Only the beta chain of fibrinogen (FGB) is cleaved, releasing fibrinopeptide B.  Human and bovine fibrinogen are unaffected.  Also cleaves Met-Lys and Arg-Ser bonds in heat-denatured bovine plasma kininogen to release Lys-bradykinin.
What are the official names of this protein?
Thrombin-like enzyme elegaxobin-2, SVTLE, Elegaxobin II, Fibrinogen-clotting enzyme, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
Protein: FADJ_PHOPR
Sequence: MTQHESANSQPSAFSLTFGDNGVAWLKIDVPNERMNTLQSAFVDQVTDVLAQLKDKKDIKGMVVYSGKPDNFIAGADIRMLAACQTADEAQQLAAKGQELFGQLEALPFHVVAAIHGPCLGGGLELALACHSRVCSDDDKTRLGLPEVQLGLLPGSGGTQRLPRLIGVANALDMILTGKQLRAKKAKNLGLVEEAVPLSILLDIAEKQALKGKPKRKGSFQEWAMGGNALGRSVVFDQAAKKTHEKTRGNYPAADAILDVIKYGLQHGMKKGLDQEAKRFGELVMTSESAALRSIFFATTAMKKESGSDALPATIKKVGVLGGGLMGGGISHVTATKAGYPVRIKDISNDGIKNALVYNFKLLDKQRKRRIISKAELQNKMFSITGGTTFTGFTNVDVVIEAVFEDINLKHQMVKDIEQQTSDYTIFASNTSSLPIHQIAAAAERPENVVGLHYFSPVEKMPLVEVIPHQGTENGSATSEQTIATVVALAKKQGKTPIVVADKAGFYVNRILAPYMNEAAAVLLSGEPIEHIDRSLLDFGFPVGPITLLDEVGVDIGAKISPILLAELGERFKAPDVFDLLLSDDRKGRKSGKGFYLYNTKKKEVDKSVYKLLSLEPEQKAAGQDIALRCTLMMLNEAARCLDEGVIKSARDGDIGAIFGIGFPPFLGGPFRYMDTLGAKRVVEMLKDHTDKYGGRFTPCDKLVAMANEEQSFYS
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_COXBU
Sequence: MNKNPFIVCLMGPTASGKTDLAIALARKLPFEIISVDSAMVYRGLDIGTAKPNEEELQLTSHRLINICDPSFPYSAGQFYKDALSEIKTIEIRNRTPLLVGGTMLYFHILEQGFSDLPTADETVRKKIQEEAAQHGWAKIHERLNAIDPKSAARINPNDAQRIQRAFEVYETTGQPLSSYQSLKRFKALPYQFINLILAPENRSWLHQRIEKRFDQMLKNNFLEEVRQLYNRGDLNSDLPAIRTVGYRQVWKYLSGEYDYETMRHKAIAATRQLAKRQLTWLRRWPDAKWFNSEDKDLISQVVDYLKGIGM
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: METN_SHIFL
Sequence: MIKLSNITKVFHQGTRTIQALNNVSRHVPAGQIYGVIGASGAGKSTLIRCVNLLERPTEGSVLVDGQELTTLSESELTKARRQIGMIFQHFNLLSSRTVFGNVALPLELDNTPKDEIKRRVTELLSLVGLGDKHDSYPSNLSGGQKQRVAIARALASNPKVLLCDEATSALDPATTRSILELLKDINRRLGLTILLITHEMDVVKRICDCVAVISNGELIEQDTVSEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQTEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEVLGYV
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PSBL_CABCA
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HIS8_PAEAT
Sequence: MSDQLERLDRLPLRTNLRGLSPYGAPQLDVPILLNVNENTHGVPADVQAAITEAVAAAATGLNRYPDREFTELREALAEYLGHGLSPDNIWAANGSNEVLQQILQAFGGPGRKALGFPPTYSMYPLLASGTDTEYVRGVRADDYGLDAQSAAAQVRETGANIVFLCSPNNPTGTGLSLDVVEAVYEAGEASQAIVIVDEAYHEFAHDNTPSALTLLPGRERLIVSRTMSKAFALAGARLGYMAAAPEVTDAIRLVRLPYHLSAVTQATALAALNHREALMADVEDIKVQRDRIVTELLRMGLKPAASDSNYVFFGGLEDPHTIWQGLLDAGVLIRDVGIPGHLRVTAGTEPETTAFLEALEALLDGTAPHRA
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: SYYC_YEAST
Sequence: MSSAATVDPNEAFGLITKNLQEVLNPQIIKDVLEVQKRHLKLYWGTAPTGRPHCGYFVPMTKLADFLKAGCEVTVLLADLHAFLDNMKAPLEVVNYRAKYYELTIKAILRSINVPIEKLKFVVGSSYQLTPDYTMDIFRLSNIVSQNDAKRAGADVVKQVANPLLSGLIYPLMQALDEQFLDVDCQFGGVDQRKIFVLAEENLPSLGYKKRAHLMNPMVPGLAQGGKMSASDPNSKIDLLEEPKQVKKKINSAFCSPGNVEENGLLSFVQYVIAPIQELKFGTNHFEFFIDRPEKFGGPITYKSFEEMKLAFKEEKLSPPDLKIGVADAINELLEPIRQEFANNKEFQEASEKGYPVATPQKSKKAKKPKNKGTKYPGATKTNEIATKLEETKL
What is the function of this protein?
Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two-step reaction: L-tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (PubMed:8509419, PubMed:3535890, PubMed:10588711, PubMed:10677221, PubMed:10766779).  The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36 (PubMed:10677221).  Also involved in nuclear tRNA export (PubMed:10588711).  Also attaches D-Tyr to tRNA(Tyr), this reaction is about 150-fold less efficient than attachment of L-Tyr (PubMed:10766779).
What are the official names of this protein?
Tyrosine--tRNA ligase, cytoplasmic, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, only a small fraction (about 1.5%) found in the nucleus.
Protein: CGT3_CAEEL
Sequence: MCKYGKSNLAAVASSTSSIIGAAAAAVAEAQPSASPSTSSSFLLLEVPFRHLLRLQPPPYFIAGTRRMAAQLDVTTLIAIVGFVFVFCLYLIHIIALSYSKYRLHHKVKEDSSLPGVSIIKPIVGKDNNLYENIESFFTTQYHKYELLFCFNSSDDEAVEVVKCLMKKYPKVDAKLFFGGETVGLNPKINNMMPAYRSALYPLILVSDSGIFMRSDGVLDMATTMMSHEKMALVTQTPYCKDREGFDAAFEQMYFGTSHGRIYLAGNCMDFVCSTGMSSMMKKEALDECGGISNFGGYLAEDYFFGRELANRGYKSAISSHPALQNSSSVSVSSFLDRICRWVKLRIAMLPHILLVEPLQDCFPSGLIMAFSLNHLVGLNIMPILILHTIYWFSMDYSLMNSMQNGKLSFSPLQFMLIWLLRELTAPFVFIKALLQPTIQWRNNVFHLAWGGQILPPKC
What is the function of this protein?
Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide to produce glucosylceramides (GlcCer).  GlcCer are known to contribute to the physical properties and physiological functions of membranes and may regulate signal transduction.  Seems to be the major active form in the nematode (PubMed:19240113, PubMed:21325339).  Only branched-chain sphingoid bases like 15-methylhexadecasphing-4-enine are used for generating complex sphingolipids in Caenorhabditis elegans (PubMed:7651085).  Together with cgt-1, plays a role in the trafficking of proteins such as mig-14 to the cell membrane in intestinal cells (PubMed:26115433).
What are the official names of this protein?
Ceramide glucosyltransferase 3, CGT-3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: UBID_YERE8
Sequence: MKYRDLRDFLSLLEQRGELKRISQPIDPYLEMTEIADRTLRAGGPALLFENPKGYNMPVLCNLFGTAKRVAMGMGQEDVSALRDVGKLLAFLKEPDPPKGFRDLFDKLPKFKQVLNMPTKCLSSAPCQEQVWEGEDVDLSRIPVMHCWPEDAAPLVSWGLTVTRGPHKERQNLGIYRQQVLGKNKLIMRWLSHRGGALDYQEWCEAHPGERFPVAVALGADPATILAAVTPVPDTLSEYAFAGLLRGHKTEVVKCLSNSLEVPASAEIVLEGYIEQGEMAPEGPYGDHTGYYNEIDSFPVFTVTHITQRKDAIYHSTYTGRPPDEPAVMGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRLAVVTIKKQYAGHAKRVMMGVWSFLRQFMYTKFVIVCDDDINARDWNDVIWAITTRMDPSRDTVLIENTPIDYLDFASPVSGLGSKMGLDATNKWPAETPREWGRPIKMDEEVRARVDAIWDELAIFSDKETKR
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y13P1_PLAF7
Sequence: MSTNINEEKCLEGDDIKYEKPDTHKNFWKSFGLNNEAGKLLYHLYGESNKIKPNILSSKHDGDKNKNDKKKEDAKLNTTYRKPQIHYPSLKKKAVKENPIDTIKHRKPLSKILEETQNYDCIKDIPISIGMNRETEKNKLHNIFVEEKCLMVPPSCAPMILTQEEKKEIIEKAQQRYIYINEENKSREEKHIQALRNYKLELIQELNEKRKLLQDIINEDKNIQGNISINQSDKRVSNKGNSYNIIQIKNDIEQCQKSIKKIEDNLNTYE
What are the official names of this protein?
Uncharacterized protein MAL13P1.147.
Protein: GAL1_THEMA
Sequence: MKVKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSERFIFHSENVNETVEMEKIEKLNKWTDYISGVIASFEKRGYRVSPVKISVSSNLPIGAGLSSSAALEVATAYAISEYFGFNVPKLELVKIAREAEVEFVGVRCGIMDQFTAVFGKKDHAIFLDTMTLEYEYVPLKLEGYEINLVDSNVKHELSSSEYNRRRQECEEVLKTLEKKSFREVTKEDLERLSGTLRKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKEGILGARMVGGGFGGGVIVLSKKGAFGKIKEELVESYRKRFGIDLIFHEIESSDGVQKI
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.