PharMolix/UniProtQA huggingface dataset:
Protein: PLS3_PITNO
Sequence: FLSLIPTAINAVSALAKHF
What is the function of this protein?
Has antiparasitic activity against trypomastigote form of T. cruzi (IC(50)=0. 46 uM) in vitro but not against L. infantum (PubMed:24113627).  Probably acts by permeabilizing cell membranes (PubMed:24113627).  In vitro, shows no cytotoxicity against macrophages (PubMed:24113627).  Has antibacterial activity (By similarity).
What are the official names of this protein?
Phylloseptin-N3, PLS-N3, Phylloseptin-8, PS-8.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MQO_CORDI
Sequence: MADSTTAQHVTDEVDVALIGAGIMSATLGAMLRTLEPGWTQVMFERLDAPAQESSSPWNNAGTGHSALCELNYTPEVKGRVQIDKALGVNEKFQISRQFWSYQVNEGVLPSPREWINPVPHVSFGRGEDQVAYLKKRYEALAAHPLFPNMQYTDDRAKFAEMLPLMADGRSEFEKVAISWTDAGTDINYGSQTRQFLKAAEKNGTEIRYGHEVKDIKRDGAKWRVTVKNVHTGDTQVIRANFVFVGAGGMALPLLQKTGIVEIRGWGGFPVSGQWLRCTNPDIIEQHAAKVYGKASIGAPPMSVPHLDTRVIDGEKGLLFGPYAGWTPKFLKKGSYLDLFKSIRPTNLMSYLGVGAQEFGLTKYLITEVMKDQAARMESLREYMPNAKDEDWELVTAGQRVQAIQPVVGPRFSTLAFGTSLINSADGSVAGILGASPGASIAPAAMLELLERCFGQKMVEWGPTIKDMIPSYGIRLATDQKLFNEIWDHTQATLQLDKK
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: LSG12_ARATH
Sequence: MGKSEKTSLGRSLVKHHNHMIQESKDKGKYYKNLQKKVLESVTEVSDIDAIIEQAEEAERLYTINHSSSTPLSINLDTNSSSSVIAAEEWREQQKIEEALHASSLQVPRRPPWTPEMSVEELDANEKQAFLNWRRMLVSLEENEKLVLTPFEKNLDIWRQLWRVLERSDLIVMVVDARDPLFYRCPDLEAYAQEIDEHKKIMLLVNKADLLPTDVREKWAEYFRLNNILFVFWSAIAATATLEGKVLKEQWRQPDNLQKTDDPDIMIYGRDELLSRLQFEAQEIVKVRNSRAASVSSQSWTGEYQRDQAVVGFVGYPNVGKSSTINALVGQKRTGVTSTPGKTKHFQTLIISDELMLCDCPGLVFPSFSSSRYEMIASGVLPIDRMTEHREAIQVVADKVPRRVIESVYNISLPKPKTYERQSRPPHAAELLKSYCASRGYVASSGLPDETKAARLILKDYIGGKLPHYAMPPGMPQADEPDIEDTQELEDILEGSESDDSAVGDETENEQVPGIDDVLDDLSSFDLANGLKSSKKVTAKKQTASHKQHKKPQRKKDRTWRVQNTEDGDGMPSVKVFQKPANTGPLTMR
What is the function of this protein?
GTPase involved in ribosome biogenesis (Probable).  Binds to 23S rRNA and associates with 60S pre-ribosomes (PubMed:25319368).  Involved in early cotyledon and leaf development (PubMed:25319368).
What are the official names of this protein?
GTPase LSG1-2, AtLSG1-2, DAR GTPase 7, Protein YEAST LSG1 ORTHOLOG 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The C-terminus is sufficient for the targeting into the nucleus.
Protein: 2ABD_CHICK
Sequence: MAGVAGGGGNGNDFQWCFSQVQGAVDEDVAEADIISTVEFNYSGDLLATGDKGGRVVIFQREQENKSRPHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAHFLLSTNDKTIKLWKISERDKRAEGYNLKDEDGRLRDPFKITALRVPILKPMDLMVEASPRRIFANAHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPHHCNVFVYSSSKGTIRLCDMRSSALCDRHSKFFEEPEDPSSRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDGAIMTGSYNNFFRMFDRNTRRDITLEASRESSKPRAILKPRKVCTGGKRKKDEINVDSLDFNKKILHTAWHPMENIIAVAATNNLYIFQDKIN
What is the function of this protein?
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit.  The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis.  During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors.  Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform, PP2A subunit B isoform B55-delta, PP2A subunit B isoform PR55-delta, PP2A subunit B isoform R2-delta, PP2A subunit B isoform delta.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOC_ACISJ
Sequence: MTAIAIHPESLRDVVASALGDRVRQISVALDEVTVVVSAARYLEAMQILRDAPDCKFEQLIDLCGVDYSAYGATGSEGPRYAVVSHLLSVSLNQRLRVKVFCSDDDFPIVASVTDIWNSANWFEREAFDLFGIVFDGHNDLRRILTDYGFIGHPFRKDFPLSGHVEMRYDADQRRVIYEPVTIEPREVTPRVIREDKYGGLH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYH_SYNC1
Sequence: MSISGIKGMNDILPSDVETWQFLEREAHRIFKLYGFAEIRVPVVEKTELFCRSIGETTDIVEKEMYTFDDRSSNSLTLRPEGTAPVMRSFIEHKLHALDPVSKLYYMGPMFRYERPQKGRYRQFHQIGAEAIGVDDPMMDAQVLAMLCHYFDAVGIDNVELHVNSLGCQECRPQYRQALTGYLESRLDKLCADCQRRYQTNPLRVLDCKVPACQEATKDAPSVLDLLCSGCNDHFAQVRQHLQELQIDYTINARMVRGLDYYTKTTFEMVTNQLGSQNAVAAGGRYDGLIKELGGPALPGIGFAMGVERLVLMKGEQQVQPPRPDVFLAALGEAAGQKAFALMYRLQRLDLRAEMAFTGKSLKAQMRRAGKLNARYVLMLGEEELASGQAQLRDMDNGSQEPIALEGIEQALLEKTRGN
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATB_METS5
Sequence: MESSMNVREYSNISMIKGPLLMVQGVADSAYNELVEVEMPNGERRRGIVVDSQKGISIVQVFEGTRGISPVGTTVRFLGRGLEVKISEEMLGRIFNPLGDPLDNGPMVIKGEKRDINGEPLNPAIRDYPEEFIQTGISAIDGLNSLLRGQKLPIFSGSGLPANILAAQIAKQATVRGEESNFAVVFGAIGVRYDEALFFRKFFEETGAINRVALIMSLANEPPVMKTLTPKTALTLAEYLAFEQDMHVLAILIDMTNYCEALREISASKEEVPGRGGYPGYMYTDLAQTYERAGKVIGKKGSITQMPILTMPNDDITHPIPDLTGYITEGQITLDRSLYNKGIYPPINVLMSLSRLAKDGIGEGKTRDDHKDLSNQLFAAYAKAVDTRGLAAIIGEDSLSDTDKKYLMFGDAFERKFVSQGVNENRDIETTLDIGWEVLSILPERELTNVKVDYIKKYHPAYRGKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: ARNC_SALCH
Sequence: MFDAAPIKKVSVVIPVYNEQESLPELIRRTTTACESLSKAWEILLIDDGSSDSSAELMVKASQEADSHIISILLNRNYGQHAAIMAGFSHVSGDLIITLDADLQNPPEEIPRLVAKADEGFDVVGTVRQNRQDSLFRKSASKIINLLIQRTTGKAMGDYGCMLRAYRRPIIDTMLRCHERSTFIPILANIFARRATEIPVHHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSLLGSVIAIGGFSLSVLLIVLRLALGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYNDVRARPRYFVQQVIYPESTPFTEESHQ
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CDK4_RAT
Sequence: MATTRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFSPRGPRPVQSVVPEMEESGAQLLLEMLTFNPLKRISAFRALQHSYLHKEESDPE
What is the function of this protein?
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition.  Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.  Hypophosphorylates RB1 in early G(1) phase.  Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.  Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity.  Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus (By similarity).
Protein: ATGT_METVS
Sequence: MFEIKARDAMGRLGLIKINGKKIETPTIMPVVHPNPKKQTVSIDLINKLSDVIITNSYITYTTPELREIAENKGIHHLTGFKNVVVTDSGSFQLSVYGNVNVEPMEIIDFQEKIGVDVGTILDIPTAPDVSREKAEKELLETFKRAEDSIQRRNDRNYKLALNGTVQGSTHLDLRRKSAEVMGKMDFEIYPIGAVVPLMEDYRYREVSEIIINSKMHLPTNKPVHLFGCGHPMLFALSVALGCDLFDSAAYALYAKNGRYLTENGTLHLDELKDLKNFPCSCKVCSEYTPKQLQNMKEKERERLLAEHNLYVTFEEIDRIKNAIKDGNLWELVEERCRSHPKLLNGLRVISKYMDFIEKYDPVSKKSGFFYTGYESMARPEIYRHKQRLNRLKFDKIYVTSISEKINTPYSENLNNIPCDVDVLIKDSVFGLVPLNIDTMYPLSQNEIPDLYDFEKNYNNDFISEFLENNAEKVLDISTYNYYISHYNSKKECEKINPDLLRISRMLEYQYGAKIIDNDFEKLSVRRSKTSGRIRNVLLDKEVVFTVRASDNFLIPAKLGAEMLHKKLEFPKYRVIVDKSVEEFARAGKSVYSKFVINCDKELRPFEEVLVVNENDDLLAYGTNLLNSQELMEFDYGVAVNIRGGLKLE
What is the function of this protein?
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
What are the official names of this protein?
tRNA-guanine(15) transglycosylase, 7-cyano-7-deazaguanine tRNA-ribosyltransferase, Archaeal tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the archaeosine tRNA-ribosyltransferase family.
Protein: BRE1_GIBZE
Sequence: MEDRKRPAISSADEIAPPSKRVAVNGSKAKDDPLDMKEESWVEAYTKGAIYRQMQEYSRKASTYESRLEELHKRSVHHDDHLRIIDAWWRQVLDEMELLLADSGVTSQTPSEPPYLSSVSFKDLHDFQKHLSEKGKGIKLRAEAILARLASSRGSIKPDAAKLESKVAGLLAAQKEYFAKLDRLKTEKDQLSEQLNAATLRYFKAEKKLDRAKSSQVQKMEQQAFANATRPSASGDVNTDSGETNGNSGELLLKYEEATAAATKQKEQLDVFLAEIKALQDENSTLKAKRDTLTDEDFIRTDVFKQFKNQNEDLIKRINTLEATNKQLREEAERLQAERTAFRTMLEADANQVTQELESEIILRDQDLARVRSARDELLAETTQHKARLDQERASVEQVKALASAKEDRITALESQLSRLQQSETQQAVSPDIEALTVEELRLKYTKLQQDFDSINMELPAIEKAYKKMKELAHRKAMDFSATEERMSILIAEKSKADQKYFAARKDADTRNNEIRSLRHQNSKSSEIIAQLKDLESQNRVLLGNLEKQLTDLKQSNASLMTENKKMEVTSLDAVRRTESLNKQVSDLSNLVKSKDAASAVVRERNVMQETEVEKMKVRLEHAQKDRDNWKNKALSNSSEEEEMLRTFALCTICRNNFKNTALKTCGHLFCNQCVDDRISNRMRKCPTCSRAFDKMDVMPVHH
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
What are the official names of this protein?
E3 ubiquitin-protein ligase BRE1, RING-type E3 ubiquitin transferase BRE1.
What is the protein family that this protein belongs to?
Belongs to the BRE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMA_LEGPC
Sequence: MKAKVIVGMSGGVDSSVAAWLLKEQGYQVEGLFMKNWEQDDHNDYCPAAKDLADAQAVCNQLRIPLHTVNFSKEYWDRVFAYFLSEYEKGRTPNPDVLCNKEIKFNAFLNHALNLGADYIATGHYAKNTIEGSIGYLFKAKDREKDQTYFLHAVEPEALSKTIFPIGDFTKPQIREFAKQLGLVTHAKKDSTGICFIGEKRFKTFLNEFILAKPGEIKSTGGKTLGQHDGLMFYTLGQRQGLGIGGLQNSTDEPWYVVDKDIASNTLYVAQGSQHPMLYSQGLICGPIHWLADYENHLPLTCFAKTRYRQTDQACMISPPDNNLHYVMFSSPQRAITPGQFIVFYEKNQCLGGATIEQIIR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4692_MYCS2
Sequence: MASGDIATVANAELDLPYGSALTSSGRISAVTEPGELSVHYPFPTMDLVVLDDALKYGSRAAKARFAVYIGPLGADTAATAREILANVPTPENAVLLAVSPDQRAIEVVYGADVKGRGIESAAPLGVSAAAASFKEGNLIDGLISAVRVMSAGVSPA
What are the official names of this protein?
Uncharacterized protein MSMEG_4692/MSMEI_4575.
Protein: GVPN_HALMT
Sequence: MTNSSRERKVRGSQIRTSRREKQDKNARNRTEKELTRLENHQTHRTKNGTSKLDERFIPEEQPFIETEAVTQVETRMRRWLDVGRPVHLIGPTGCGKTALAMHVARERDRPVVWINGDADLTTSDLVGEYAEKERISERDKYVHNVVKSKDIVRDRWVDNPLTLAVREGATLVYNEFSRTKPVANNVLLSVFEEGVLELPGQRGKSRYVDVHPDFRAILTSNSVEYAGVHEPQDALLDRLVGLYLDFYDRETEVEIVRAHVDDFDTEDTEQIVRLMRELRERLDVNVGTRAAIMAAEGLTTVDDLDRSILTDICVDVLASKVAQHSDVHELRDEVEATIKGMEGTLS
What are the official names of this protein?
Gas vesicle protein GvpN.
What is the protein family that this protein belongs to?
Belongs to the CbbQ/NirQ/NorQ/GpvN family.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: LACA_STRR6
Sequence: MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTLAVAAEVNKEEQNLGIVIDAYGAGPFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMITMGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacA.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: PEPT_KLEP3
Sequence: MDKLLERFLQYVSLDTQSKPGVRQVPSTEGQWKLLRLLQAQLEEMGLVKVTLSEKGTVMGTLPANVEGDIPAIGFISHVDTSPDFSGKNVNPQIVENYRGGDIALGIGDEVLSPVMFPVLHQLLGQTLITTDGKTLLGADDKAGIAEIMTALATLQAKNIPHGDIRVAFTPDEEVGKGAKHFDVEAFDARWAYTVDGGGVGELEFENFNAASVTIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADEAPETTEGYEGFYHLTSIKGSVDRAEMHYIIRDFDRKHFEARKRKMMEIAKKVGKGLHPDCYIELVIEDSYYNMHEQVIAHPHVVDIARQAMVDCDIEPQMKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAELTATRKGK
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALTA1_ALTBO
Sequence: SLFAAAGLAAAAPLESRQDTASCPVSTQGDYVWKISEFYGRKPEGTYYNSLGFNIKATNGGTLDFTCSAQADKLEDHKWYSCGENSFMDFSFDSDRSGLLLKQKVSDDITYVATTTLPNYCRAGGNGPKDFVCQGVS
What are the official names of this protein?
Allergen Ulo b 1, Alt a 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the ALTA1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GCH1_STRPJ
Sequence: MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQEIFSGLGQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHFLPFYGRAHIAYIPDGRVAGLSKLARTVEVYSKKPQIQERLNIEVADALMEYLGAKGAFVVIEAEHMCMSMRGVRKPGTATLTTVARGLFETDKDLRDQAYRLMGL
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: SYT_METHJ
Sequence: MRLLLIHSDFIEYEAKKKTKFAEDPCNPADRLDDALVAFCAVESPDADDIDDVICQTVTAIGEMAGKVECNRVMVYPYAHLSSDLAAPDLAVAALKAIEESLEKAGYEVKRAPFGWYKSFSLSCKGHPLSELSRSITPSEDAVKPEKKHIEHKFFVLTPEGTIHDVQEYMDDSPFAALIKKEIGTAVPVGGEPVHVDLMRSKEFVDYEPVSDVGHLRWLPRGKLVRDLLADYALSLVLDYGASPVETPVMYDLADKAIFEHADKFGERQYRFKSGNRNMMLRFAACFGMFTTMRSMHISPNHLPMKMYELSTYSFRHEQKGEVIGLKRLRAFTMPDMHSLCKDLENALTCFEEQLAIGWKTGRDFGTQLVAVFRCTEEFYSEYEGWIKKIVKDSGVPILIETLSDRVHYWIAKIDLAAIDGQNRPIENPTVQIDVESSKRFGIKYHLADGTEVYPPILHCSPTGSVERVFCAILENTVNQKVAHLPTWLTPTQVRIIPVTDNHLGYAKDIAEKLTKARIRADIDDRDDSLNKKIRAAGMDWVSYVIVVGDSEMNSGNLTVTVRSESEPNKPQKITCTAEKLIEMIGKETSGKPFRPLYTPRMLSLKPRYI
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_CLAMS
Sequence: MAPKKKVTGLIKLQIKAGAANPAPPIGPALGQHGVNIMEFCKAYNAQTESQRGNVIPVEITVYEDRTFTFILKTPPAAELIKKAAGVAKGSGTPHTVKVAKLTMDQVREIAEQKQADLNANDIDAAAKIIAGTARSMGITVEA
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: M1_INBMP
Sequence: MSLFGDTIAYLLSLTEDGEGKAELAEKLHCWFGGKEFDLDSALEWIKNKRCLTDIQKALIGASICFLKPKDQERKRRFITEPLSGMGTTATKKKGLILAERKMRRCVSFHEAFEIAEGHESSALLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHSHRAHSRAARSSVPGVRREMQMVSAMNTAKTMNGMGKGEDVQKLAEELQSNIGVLRSLGASQKNGEGIAKDVMEVLKQSSMGNSALVKKYL
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: LEUD_SACS2
Sequence: MIIEGPVIKFGDKIDTDIIIPARYLKYTDPQYLAQHVMEPLDPEFYKKASKGVIIVAGKVFGMGSSREQAAIALKAAGVKAVVAESFARIFYRNAINNGLPVITLPNSTKEIDENSYVKIDVETGEILVGNKVLKGKGITGMALEILQAGGIMEYLKKMQTVNRN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: GRDH_DAUCA
Sequence: MASGGQFPPQKQESQPGKEHLMDPSPQHASPHYKPANKLQGKVALVTGGDSGIGRSVCYHFALEGATVAFTFVKGHEDKDANETLELLRKAKSSDAKDPIAIAADLGFDDNCKKVVDQVVNAFGSIDVLVNNAAEQYKASTVEDIDEERLERVFRTNIFAYFFMARHALKHMREGSTIINTTSINAYKGNAKLLDYTATKGAIVAFTRGLSLQLISKGIRVNGVAPGPVWTPLIPSSFDEEEVKQFGSEVPMKRAGQPYEIATAYVFLASCDSSYYSGQVLHPNGGAIVNG
What is the function of this protein?
May act as a short alcohol-polyol-sugar dehydrogenase possibly related to carbohydrate metabolism and the acquisition of desiccation tolerance.  May also be involved in signal transduction.
What are the official names of this protein?
Glucose and ribitol dehydrogenase, Carrot ABA-induced in somatic embryos 5 protein.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MVP_SBMVG
Sequence: MATIMIGSMAISVPNTHVSRASNSVMPVQAVQMAKQVPSARGVLYTLKREGSTQVIKHEEALRKFQEAFDQDVGIQRRLLVNKHSSIQSTKEGWFDLASLNFRAGSSKEAAIARRKQEEEDFLNGKYEQQFYAGVSATKSMKFEGGSVGFRTKYWRPTPKKTKERRATSQCRKPTYVLEEVLSIASKSGKLVEFITGKGKRVKVCYVRKHGAILPKFSLPHEEGKYIHQELQYASTYEFLPYICMFAKYKSINADDITYGDSGLLFDERSSLTTNHTKLPYFVVRGRRNGKLVNALEVVENMEDIQHYSQNPEAQFFRGWKKVFDKMPPHVENHECTIDFTNEQCGELAAAISQSIFPVKKLSCKQCRQHIKHLSWEEYKQFLLAHMGCHGAEWETFQEIDGMRYVKRVIETSTAENASLQTSLEIVRLTQNYKSTHMLQIQDINKALMKGPSVTQSELEQASKQLLAMTQWWKNHMALTDEDALKVFRNKRSSKALLNPSLLCDNQLDKNGNFVWGERGRHSKRFFANYFEEVVPSEGYSKYVIRTNPNGQRELAIGSLIVPLDFERARMALQGKSVTREPITMSCISRQDGNFVYPCCCVTHDDGKAFYSELKSPTKRHLVIGTSGDPKYIDLPATDADRMYIAKEGFCYLNIFLAMLVNVNEDEAKDFTKMVRDVIVPRLGKWPTMLDVATAAYMLTVFHPETRNAELPRILVDHACQTMHVIDSFGSLTVGYHVLKAGTVNQLIQFASNDLQSEMKFYRVGGEVQQRMKCETALITSIFKPKRMIQILENDPYILLMGLVSPSILIHMYRMKHFEKGVELWISKEHSVAKIFIILGQLTKRVAANDVLLEQLEMISETSERFMSILEDCPQAPHSYKTAKDLLTMYIEGKASNNQLVENGFVDMNDKLYMAYEKNLLRSLEAGMARIKLVGKIFYNMAIEKICSTYGEMFDKESCRRKQRIFRKLCECVLHECPVTPKKCKKYTFPKM
What is the function of this protein?
Allows efficient cell to cell propagation, by bypassing the host cell wall barrier.  Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding (By similarity).
What are the official names of this protein?
P3N-PIPO polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae P3N-PIPO polyprotein family.
What are the subcellular locations of this protein?
Host cell junction, host plasmodesma.
Protein: ATPG_METPP
Sequence: MAAGKEIRGKIKSVENTKKITKAMEMVAASKMRKAQERMRAARPYADKIRNITANLAQANPEYTHPFMAVSATAAKTAGFVVVTTDKGLCGGLNTNVLRAVTGKLRELESQGSKAEAVAIGNKGLGFLNRIGAKVVSHATQLGDAPHLERLIGPVKVLLDAYAEGKLNAVYLCYTRFINTMKQEPVVEQLLPLASDKLKADAGEHGWDYLYEPDAKTVIDDLLLRFVEALIYQAVAENMASEQSARMVAMKAATDNAGTLIGELKLVYNKTRQAAITKELSEIVSGAAAVG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DPOA2_RAT
Sequence: MAVSTQQLAEELQIFGLDCEDSLLEKLAELCTLYRQTEERMVSELIAFCTSAGKSCLTGEILSSFEHEVLNKKLSKACHSASKDNRHAGARDIVSIQELIEAEEEEETLLSAYTTPSKGPHKRVSSTPETPLTKRSISTRSPHQLLSPSSFSPSATPSQKYSSRTNRGEVVTTFGSAQGVSWSGRGGSGSISLKVMGYPEPLTSSYKTMFQQLPDIREVLTCKIEELGSELKEHYKIEAFTPLLVPAQEPVILLGQIGCDSNGRLNSKSVILEGDREHSSGAQIPVDVSELKDYSLFPGQVVIMEGFNTTGRRLTATKLYEGVPLPFYQPTEEEGDFEQTMVLVACGPYTTSDSITYDPLLDLISTINHDRPDVCILFGPFLDAKHEQVENCKLTSPFEDIFKQCLRTVIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFTFSELPREDKKRVQFVSEPCNLSINGVMFGLTSTDLLFHIGAEEICSSSGTSDRFSRILKHILTQRSYYPLYPPHEDMAIDYENFYTYAQLPVTPDVFIVPSELRYFVKDIFGCVCMNPGRLTKGQVGGTFGRLYLRRQPKGTDSEGRQGLSVAAQVVRI
What is the function of this protein?
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity).  During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity).  The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.  These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).
What are the official names of this protein?
DNA polymerase alpha subunit B, DNA polymerase alpha 70 kDa subunit, DNA polymerase subunit II.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase alpha subunit B family.
What are the subcellular locations of this protein?
Nucleus.