PharMolix/UniProtQA huggingface dataset:
Protein: FPG_BURTA
Sequence: MPELPEVEVTRRGIEPFVAGRRVERVDVRTAMLRWPVPADFAEMLRSREVLGVERRGKYLLFEVDAGWFIVHLGMTGTLRVLPNDAPPPAPAKHDHVDWVFDEFVLRFRDPRRFGAVLWHPRDAGDVRAHPLLASLGVEPFSAAFSGALLFKRTRGRTVSVKQALLAGDIVVGVGNIYASESLFRAGIRPTTAAGRVSLPRYERLADAVRATLADAIERGGSTLRDFVGSNGESGYFQLDCFVYDRAGEPCRVCGAPIRQIVQGQRSTYYCPNCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: NDHI_CYAP4
Sequence: MLKFLSKIGDYTKETIQSARYIGQGLAVTFDHMRRRPVTVQYPYEKLIPSERFRGRIHFEFDKCISCEVCVRVCPINLPVVDWEFNKELKKKQLKHYSIDFGVCIFCANCVEYCPTNCLSVTEEYELSVYDRHELNFDNVAMGRLPYKVTEDPMVTPIREFAYLPEGTLSGHDLPEPAKRAGQLPQDIVKTLK
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, NAD(P)H dehydrogenase I subunit I, NDH-1 subunit I, NDH-I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: Y311_METM5
Sequence: MKLIGITGMPGSGKSAITKLAEKYKIIVVSMGDVVRHETSKQGLTLNPENVGNTAVKLREIHGNEAIAVPCLNYVNEKYKNEDFVIIEGIRSIYEVNYLGKNAKLDIIAIHSSPKTRFERLSGRNREDDSNDWNTFVERDERELNFSIGNVISLADYMVVNEGNYMDFINNLENTLKKIIKAD
What are the official names of this protein?
UPF0200 protein MmarC5_0311.
What is the protein family that this protein belongs to?
Belongs to the UPF0200 family.
Protein: EFP_ANAMF
Sequence: MAERGSDIRPGQILDHNGSLYLVVKTMHTQPGKGGAYIQAELKNLKTGAKYQERFRSDGYVKRAIVEEVEYQYIFGDGALLTLMNTATYEQVSISADMLGEKGVYLKEGIILTLSFYQGQVVAARVPDYVVLEVVETESVIKGQTASSSYKSAVLENGERISVPPFIKVGERIVVYTVDDTYYERAKD
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AERA_AERHY
Sequence: MQKIKLTGLSLIISGLLMAQAQAAEPVYPDQLRLFSLGQGVCGDKYRPVNREEAQSVKSNIVGMMGQWQISGLANGWVIMGPGYNGEIKPGTASNTWCYPTNPVTGEIPTLSALDIPDGDEVDVQWRLVHDSANFIKPTSYLAHYLGYAWVGGNHSQYVGEDMDVTRDGDGWVIRGNNDGGCDGYRCGDKTAIKVSNFAYNLDPDSFKHGDVTQSDRQLVKTVVGWAVNDSDTPQSGYDVTLRYDTATNWSKTNTYGLSEKVTTKNKFKWPLVGETELSIEIAANQSWASQNGGSTTTSLSQSVRPTVPARSKIPVKIELYKADISYPYEFKADVSYDLTLSGFLRWGGNAWYTHPDNRPNWNHTFVIGPYKDKASSIRYQWDKRYIPGEVKWWDWNWTIQQNGLSTMQNNLARVLRPVRAGITGDFSAESQFAGNIEIGAPVPLAADSKVRRARSVDGAGQGLRLEIPLDAQELSGLGFNNVSLSVTPAANQ
What is the function of this protein?
Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and host cell death.  The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter.
What are the official names of this protein?
Aerolysin.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane. Note=Secreted as a soluble precursor.
Protein: FABZ_SALNS
Sequence: MTTNTHTLQIEEILELLPHRFPFLLVDRVLDFEEGRFLRAVKNVSVNEPFFQGHFPGKPILPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVTFEKTRRGLTRFKGVALVDGKVVCEATMMCARSREA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMF_MARMS
Sequence: MVLKSKNTKSKRTNKLELHPRNPHRARYDFALLADSCPELSGFIQLNQYGNESVDFANPNAVKTLNRALLNHFYGVAFWDIPPGYLCPPIPGRADYIHYLADLLAASNLGVIPRGKGVKVLDVGVGANCVYPIIGHQEYGWQFVGSDVNPVAVATCDTIVKSNPCLKGAISARLQTQSAKLFDGVWKEKDRFDLTLCNPPFHTSESAMIDESQRKWRGVKGKKTTTQKPVLNFGGTAAELWCDGGEAGFVSRMVKESVQYADRCFWFTSLVARQGNLDAIYRTLKDVGARQVKTIEMAQGQKISRFVAWSFLGDDQIDYWKDNYWQN
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREA_ASPFU
Sequence: MHLIPKELDKLVISQLGFLAQRRLARGVRLNHAEAAALISSNLQELIRDGHYSVADLMSIGKTMLGRRHVLPSVVHTLVELQVEGTFPTGTYLVTVHHPISSDDGDLEKALYGSFLPIPPADTFPDPNPDDYLPEKMPGAVLPVKNERITLNDGRKRIRLKVMSKGDRPIQVGSHYHFIETNPQLHFDRLRAYGYRLDIPAGTSVRFEPGDTKTVTLVEIAGNRIIKGGNSIASGKVDISRAEEILQRLQVEGFAHVPEPAPTADSALIAPFTMDREAYARMFGPTTGDLVRLGLTNLWVRVEKDCTVYGDECAFGGGKTLREGMGQSSERSATECLDTVITNALIIDWSGIYKADIGIKNGLISAIGKAGNPDMMDGVHPDMIVGSSTDVIAGENKIVTAGGFDTHIHFICPQQVDEALASGITTFLGGGTGPSTGTNATTCTPGPTLMRQMIQACDGLPINVGITGKGNDSGGKSIEEQIRAGAAGLKLHEDWGSTPAAIDTCLDMCDKFDVQCMIHTDTLNESGFVEQTVKSFKNRTIHTYHTEGAGGGHAPDIISVVEHPNVLPSSTNPTRPFTMNTLDEHLDMLMVCHHLSKNIPEDVAFAESRIRAETIAAEDVLHDLGAISMMSSDSQAMGRCGEVILRTWNTAHKNKAQRGPLKEDEGTGADNFRVKRYISKYTINPAIAQGMSHLIGSVEVGKLADLVIWHPSTFGTKPAQVLKSGMIVASQMGDPNGSIPTIEPVVMRRQFGAFVPSTSIMWVSQASIDDGIVQSYGLKKRIEAVRNCRNIGKKDMKFNDVMPKMRVDPESYVVEADGVLCDAEPAEALPLTQDYFVY
What are the official names of this protein?
Urease, Urea amidohydrolase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
Protein: SLMA_YERPN
Sequence: MAEKENTKRNRREEILQALAQMLESSDGSQRITTAKLAANVGVSEAALYRHFPSKTRMFDSLIEFIEDSLMSRINLILQDEKETFNRLRLILLLVLGFAERNPGLTRIMTGHALMFEQDRLQGRINQLFERIEMQLRQVLREKKLRDGQGFIHDEALLATQLLAFCEGMLSRFVRSEFRYCPTQEFDSRWPLIVAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RNA14_CANGA
Sequence: MSTTNEETQANASKDYSEDALKMSYAAQPLDIMRALKLIEYYESKDDYDNSRKLYAELHERFPLYSPLWTMHLQSELQRNEFDTVEKLLAQCLAGDLENNDLSLWSTYLDYVRRKNNLITGGQEARAVVIKAFKLVMDKCATFEPKASSFWNDYLGFLHQWKPMNKWEEQQRLDMIREVYKKMLCVPFDKLEKMWNQYTLWEQETNTLTARKFIGELSADYMKARSIYQELLNVTANIRRTSPLNLRTANKNNIPQYVLPCKKNDHTQLEAWLKWIAWEKENKLELTEDALKDRVTYVYKQAIQQLLFEPEIWYDYVMYEFDNDAARKNILKVALQANPTSPTLTFKLAECYEVENKSEEVQNCFEKTIDELLRQYKNDNGNDELSSDIIWERKTLTYIYCIYMNTMKRLSGLSAARAVFGKCRKLKKAMTHDIYVENAYLEFQNQNDHKTASKVLELGLKYFGDDGEYINKYMDFLSLLNRGSQMKTLFETSIEKVEDLRQLKKIYVKMIGYESKYGNLNNVYQLEKRFFEKFPDTDLIQLFSTRYKIQDDNKIKNLELTYKLPDIISSDGDPSGVDKSFKKRQIENDENLPDSKRQKSQPLLPKEILDILAVLPKKQYFKNAFLDPSNLVNYLNEQVKLADEEN
What is the function of this protein?
Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
mRNA 3'-end-processing protein RNA14.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nucleus and/or cytoplasm.
Protein: GCE_CERUI
Sequence: MFKPSFVALALVSYATAQASAPQWGQCGGIGWTGPTACPSGWACQQLNAYYSQCLQGAAPAPARTTAAPPPPPATTAAPPPPTTSAPTGSSPVAGACGAIASTVPNYNNAKLPDPFTFANGTALRTKADWSCRRAEISALIQNYEAGTLPPKPPVVTASFSKSGNTGTLAITAGLSNSQTIKFSPTISYPSGTPPANGWPLIIAYEGGSIPIPAGVATLTYSNSDMAQQNSASSRGQGLFYQLYGSTHSASAMTAWVWGVSRIIDALEMTPTAQINTQRIGVTGCSRDGKGALMAGAFEERIALTIPQESGSGGDACWRLSKYEIDNGNQVQDAVEIVGENVWFSTNFNNYVQKLPTVPEDHHLLAAMVAPRAMISFENTDYLWLSPMSSFGCMTAAHTVWQGLGIADSHGFAQVGGHAHCAWPSSLTPQLNAFINRFLLDQSATTNVFTTNNQFGKVQWNAANWITWTTPTLT
What is the function of this protein?
Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin (PubMed:25425346, PubMed:26712478).
What are the official names of this protein?
4-O-methyl-glucuronoyl methylesterase, Glucuronoyl esterase, GE.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate esterase 15 (CE15) family.
Protein: EFL1_HUMAN
Sequence: MVLNSLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQIRGITMKSSAISLHYATGNEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKIGIKKEVLMKTLWGDYYINMKAKKIMKGDQAKGKKPLFVQLILENIWSLYDAVLKKDKDKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCQKLPSPLDITAERVERLMCTGSQTFDSFPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAQRRERARQRHAEKLAAAQGQAPLEPTQDGSAIETCPKGEEPRGDEQQVESMTPKPVLQEENNQESFIAFARVFSGVARRGKKIFVLGPKYSPLEFLRRVPLGFSAPPDGLPQVPHMAYCALENLYLLMGRELEYLEEVPPGNVLGIGGLQDFVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQILIQETGEHVLVTAGEVHLQRCLDDLKERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQMKEDQSKIPEGIQVDSDGLITITTPNKLATLSVRAMPLPEEVTQILEENSDLIRSMEQLTSSLNEGENTHMIHQKTQEKIWEFKGKLEQHLTGRRWRNIVDQIWSFGPRKCGPNILVNKSEDFQNSVWTGPADKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQGASDLAKEGQEENETCSGGNENQELQDGCSEAFEKRTSQKGESPLTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATGDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes.  Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.  Has low intrinsic GTPase activity.  GTPase activity is increased by contact with 60S ribosome subunits.
What are the official names of this protein?
Elongation factor-like GTPase 1, Elongation factor Tu GTP-binding domain-containing protein 1, Elongation factor-like 1, Protein FAM42A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.
Protein: SYE_PAEAT
Sequence: MTTASASNAASSAIPAVNAETPVRVRFCPSPTGTPHVGLIRTALFNWAYARHTGGKLIFRIEDTDSARDSEESYHQLLDALKWLGINWDEGVEVGGPHEPYRQSQRGDIYQDVIAKLKAGGHVYESYSTPDEIEARHKAAGRDPKLGYDGFDRHLTDEQLAQFKAEGREAVLRLRMPDEDLTFNDLVRGEITFKAGSVPDFAVVRANGAPLYTLVNPVDDALMGITHVLRGEDLLSSTPRQIALYRALYAIGVAEYMPEFGHLPYVMGQGNKKLSKRDPESSLFLHRERGFIPEGLLNYLSLLGWSLSADEDIFTVEQLVANFDIHDVLGNPARFDIKKAEAINGTHVRMLAAEDFKERLVPYLRAAGFVGEILTPRQEEILAEAAPLVQERITLLGEAPEMLAFLFKADDAIDVADDARKGLPQNLEEVLDAALAALEPIGEWTAENIQTALKQALVEDLGIKPRAAFGPVRTAISGRRISPPLFESMVILGKDSSLARVRAFRG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXT_FERNB
Sequence: MIIGVSGIQGDFREHKWMIEKLGHESYVVRTPEDLEKVDGLIIPGGESTTMIRIMKRIGLFEKLKEKILNGLPVYGTCAGLIVLAKEIENYPQESLGVIDIKVMRNAYGRQVDSFDEMVEIKGFNKPFKAIFIRAPRVDGWGPEVDVLSTLDNHPIMLRQKNVLVTSFHPELTDDTRVHEYFIKMVEEYRK
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: EFTU_SCHPO
Sequence: MNSAKATSLLFQGFRKNCLRLNRISFASGLINRFTVPARTYADEKVFVRKKPHVNIGTIGHVDHGKTTLTAAITKCLSDLGQASFMDYSQIDKAPEEKARGITISSAHVEYETANRHYAHVDCPGHADYIKNMITGAATMDGAIIVVSATDGQMPQTREHLLLARQVGVKQIVVYINKVDMVEPDMIELVEMEMRELLSEYGFDGDNTPIVSGSALCALEGREPEIGLNSITKLMEAVDSYITLPERKTDVPFLMAIEDVFSISGRGTVVTGRVERGTLKKGAEIEIVGYGSHLKTTVTGIEMFKKQLDAAVAGDNCGLLLRSIKREQLKRGMIVAQPGTVAPHQKFKASFYILTKEEGGRRTGFVDKYRPQLYSRTSDVTVELTHPDPNDSDKMVMPGDNVEMICTLIHPIVIEKGQRFTVREGGSTVGTALVTELLD
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CCNC_CAEBR
Sequence: MALDFWKSSHAQQWIFDKTEIWKQRAEDMKTYSEEEYSRLNIFWANFITAVATECAHSQANVGCKLRQQVIATAIVYFKRFYLRQSFRDMCPFLVASTALFLACKVEEHTTLSVSSFLKNTALVLPKRWGVAFETNSAKNGVLYDSEFILVEILDCCLVVHHATRPMFELLEDWKQHTLTSTNTPVKDFDQIEIQCQKVVNDTLRCDVGLMFAPHCIGLASISVGMELMGRGEELEDWLVEVDTDMDKLADCINQIYTMYQLWRSFDEKEEVKKLMAKLPKPNTPIPPPQQQQSSYHM
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Binds to and activates cyclin-dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
What are the official names of this protein?
Cyclin-C.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: UVRB_PROMP
Sequence: MNNYKLQAPYQPNGDQPKAIKKLVQGVNSGEEFQTLLGATGTGKTFTIANVIQQTGRPALILAHNKTLAAQLCNELRQFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFAVGESIDLRSSLRALVDNQYTRNDTEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEIEAIRFVDPLTGEILESLDQVSVYPAKHFVTPKERLDSAISAIRNELKEQLDKFAYEGKLLEAQRLEQRTKYDLEMLREVGYCNGVENYARHLAGREEGTPPECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQARKKVLIDHGFRLPSAADNRPLKCEEFWEKSRQTLFISATPGQWELDQCEGKFIEQVIRPTGVLDPIIDVRPSDGQIDDLLSEIRVRAKKNQRVLVTTLTKRMAEDLTDFLSDNKVRVRYLHSEIHSIERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTESMKRAISETDRRRTIQKKYNQINGITPKPAGKKIENSILSFLELSRKLDTGGLSKDLINIVSNKTDDILNAKDNQCLLDEMPSLIDKLENKMKDAAKELNFEEAANLRDRIKKLRQKLSRNT
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCPA_EXISA
Sequence: MEAYNVKIDTFEGPLDLLLHLIGKMEIDIVDISVAEVTDQYVGYIRTMQKFELDVASEYLVMAATLLQLKSKQLLPPVPVEDEEVPDFSEEPTREGLIRQLIEYKAYKEAVVFMREQEEHRLELYTRPGEDLTTYMSEEVSKYDGPLNFSDLLHAYSKMIERKRWKERRKKTIKREERTLEEQMTRLHEHVSSTRQTSFFAFFVERPNVSDLVVTFMALLELIKLRIVETKQLDQDIQISFIEASKKGDEAVAVL
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: YIHY_SALNS
Sequence: MLKTVHQKAGRHTRPVRAWLKLLWQRIDEDNMTTLAGNLAYVSLLSLVPLIAVVFALFAAFPMFSDVSIQLRHFIFANFMPATGDVIQRYIEQFVANSNKMTAVGACGLIVTALLLMYAIDSALNTIWRSKRTRPKVYSFAVYWMILTLGPLLAGASLAISSYLLSLRWASDLNTVIDNVLRILPLLLSWISFWLLYSIVPTTRVPNRDALVGAFVAALLFEAGKKGFALYITMFPSYQLIYGVLAVIPILFVWVYWTWCIVLLGAEITVTLGEYRKLKQAAEQEEADQP
What are the official names of this protein?
UPF0761 membrane protein YihY.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DUT_SYNP2
Sequence: MHLRLLKLHPNAIIPKYQHEGDSGVDLHAIEPVAIAPHKTALIKTGLAAEIPIGTELQIRPRSGLALKQSVTVLNSPGTIDANYRGEIGVILINHSDTVFEVKAGMRIAQMVMVPVMHLDITVVDKVSDTSRGTGGFGSTGT
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: COR1A_MOUSE
Sequence: MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERKCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDSARRRATPEPSGTPSSDTVSRLEEDVRNLNAIVQKLQERLDRLEETVQAK
What is the function of this protein?
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion.  In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
What are the official names of this protein?
Coronin-1A, Coronin-like protein A, Clipin-A, Coronin-like protein p57, Tryptophan aspartate-containing coat protein, TACO.
What is the protein family that this protein belongs to?
Belongs to the WD repeat coronin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria- infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.
Protein: VP5_IBDVB
Sequence: MVSRDQTNDRSDDKPVRSNPADCSVHTEPSDANNRTGVHSGRHPGEAHSQVRDLDLQFDCGGHRVRANCLFPWIPWLNCGCSLHTAGQWELQVRSDAPDCPEPTGQLQLLQASESESHSEVKHTSWWRLCTKRHHKRRDLPRKPE
What is the function of this protein?
Plays a role in the release of virion progenies by disrupting the host plasma membrane.
What are the official names of this protein?
Protein VP5.
What is the protein family that this protein belongs to?
Belongs to the avibirnavirus/aquabirnavirus VP5 protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: UPP_THESQ
Sequence: MKNLVVVDHPLIKHKLTIMRDKNTGPKEFRELLREITLLLAYEATRHLKCEEVEVETPITKTIGYRINDKDVVVVPILRAGLVMADGILELLPNASVGHIGIYRDPETLQAVEYYAKLPPLNDDKEVFLLDPMLATGVSSVKAIEILKENGAKKITLVALIAAPEGVEAVERKYKDVKIYVAALDERLNDHGYIIPGLGDAGDRLFRTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: OASL2_RAT
Sequence: MDTLPDLYGTVGDSLDYFLEHSLQPQRDWKEEGKDAWERIERFFREKCFCDELLLDQEVRVLKVVKGGSSGKGTALNHRSDQDMILFLSCFSSFKQQARDRKAVIDFIKSKLIHCRKSLAYNITVRQHKEGKRTPRSLTLEIQSRKSNDIICMDILPAYNALGSFSRDCKPEPEIYENLIRCKGYPGDFSPSFAELQRHFVKSRPVKLKNLLRLVKFWHLKYLRHKYRRAVLPSKYALELLTIYAWEMGTDSSDNFNLDEGFVAVMELLRDYQDICIYWTKYYDFQNEVVRNFLKEQLKGDRPIILDPADPTNNLGRRGKWELVAKEATYCLLQLCCVTADRWNVQVSIAHYLRGARDVQVTVKQTGREEWILLTNPHSPIRKLKAKIKKRMNLCGELRISFQEPGGERQPLSGRKTLSDYGIFSKVNIRVMETFPPEIQVFVRYPGGQNKPFAIDPDATILSLWEKIEEDGGPCTEDWVLLFEGEELDDDDNLAELQIKDCDTIQLSRVS
What is the function of this protein?
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response.  Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation.  Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication.  Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L (By similarity).
What are the official names of this protein?
2'-5'-oligoadenylate synthase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the 2-5A synthase family.