PharMolix/UniProtQA huggingface dataset:
Protein: RL14_PHYAS
Sequence: MIQKNSRLVVADNSGAKEVLVIGILGGTRRRYANIGDVVVVAVKSGSGGTVKKHDVLKGVIVRSKSGIRHENGSYIKFYDNALVLLKEDLSIIGTRIFGPVVRELGKKFSKIVSLAQLVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: IAA2_ARATH
Sequence: MAYEKVNELNLKDTELCLGLPGRTEKIKEEQEVSCVKSNNKRLFEETRDEEESTPPTKTQIVGWPPVRSSRKNNNSVSYVKVSMDGAPYLRKIDLKTYKNYPELLKALENMFKVMIGEYCEREGYKGSGFVPTYEDKDGDWMLVGDVPWDMFSSSCKRLRIMKGSDAPALDSSL
What is the function of this protein?
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.  Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE).  Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
What are the official names of this protein?
Auxin-responsive protein IAA2, Indoleacetic acid-induced protein 2.
What is the protein family that this protein belongs to?
Belongs to the Aux/IAA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AFVB_ASPFN
Sequence: MRIFHFSNKFPPDDLADLFRRLRLHSKCPNHVILARVLEEVTDVVREEIAELPAELRSLLPPFQSILDLAESFNWHQGPLSGTFECVFLVLMPVCLFVGRPDEFVFRRDTSLFTGLGLGFLAATAIVASPSLCSVPVTVAEVVRMAMRTGLLIYQRSQDLEPQSLDGALESWTSIVKGMGEVAVREGIDEYNSSTDTPQPSSIYISVVEPDGSVFINGPPSRLRKFFSTSGKVQSAAHAPLPVYGGPCHAPHLYDHSHSSWAVKKCRAKVLSRDLSHAAYLLSMADGNPLKADTVLELFESATYILLTSIIRWGDVVNAITASSPLLEKDMKLQVEILRPSPVVDGLVSAIQKSHPGCSAYVVDLGEWIFDDTHISPHGAHEKIAVIGMSCRLPGGADDLELLWELLREGRDVHRKVPADRYDVDSHTDITGKQRNTSHTPFGCFVDQPGLFDAGFFDMSPREAGQTDPTHRLALLTAYEALEQSGYVPDRTRSTRRERVGTIYGQCSDDYRECNAGQDIDMYFIPGNYRAFAPGRISYFFKFSGPSFNIDTACSASLAAVQIACSVLSRGEADMVVAGGLNILTGSDSFAGLSKGFFLSKTGNCQVFDDAADGYCRGDGIGSIILKRLSDAQQDNDNILGLILGSATNHSSNAISITHPHAPTQANLYRSTLMQAGVRPQDVDLVEMHGTGTQAGDAAEIESVTKVFSPAVPRRSQPLRISSVKANVGHGEAAAGITALIKALLIFKHNEIPPQVCLRTTLNSKFPDLRQLNVHIPKKIIPWPRLPGRKRYIMVNNFSAAGGNTSLLLEEPPARPDPKGCPQTRFVVTVSAKSTVSLIRNLEGLLGFLKMDPFVDLASLAYTTTARRMHHKYRIVVHGASIQEIVKSLEQHISIAETQCAIQKAPTIGFVFSGQGSFSQGVGRQLFQEYPPYRNEIQRLDEICTSHGFDSILPAITSRSSDILEISPFMAQLVTVCVQIALCRLWRSLGVIPNVVVGASLGEYAALYAAGTLSASDVIYLVGQRARLMQELCTINSHSMLAVKATIGEIRHTVRNNAYEFACINGPRDVTLAASVEDINDIQQTLVSQGYRVAKLNVPFAFHSSQIEPILEPYNKIAHSVIFRNLKTALISPLLSDVVFDNKSFPPSYLRDSTRGTVQFSDAMTKAQEIGLVDSKTVWVEIGVHQTYTGAMRANIPNLEVVAPSLRSDESNWHTLAASMSALHSAGVHLDWNTWYKPFESQLRLLNLPPYQWNLKNHWIQHNGDWLLLKDKRSRTGYERSPAPAPPPLRTALVHHILEESFGKDGGTVVIQSNVTDDEFHAVASGHQMSGRPLVSVFAYTDIALIMARYMYSRLKSGTELSAMDFGKVRVFQGLIPRKDRSKPQYVRMRMQADPMCSSMPLSLHRVLDDEMNEEELAIGVVTCGDSHSWRDEWAAYSYLLTSRIEALHQLADQGLASRVSKDLVYTLFKNVVDYAEHYRGIQSAVMYGLEAVADVILSPSQDSRWTAPPHHIDPITHVGGLILNAGPAMDHTNTIYIMEGWESMRFSDSLMAGELYRSYVKMNPANDNSGFFSGDVYILHGNRVIGRVREMTLRPLPRILMSRFFDPPDSQYGQMAQQEPSTALPSTPQHTSSAKTTESTPSQQDESDNTSLATPENENKAPISGSWPNANSQLVRDAIALIASETGVEPDALTDETEFSAVGVDSLLSLVLVEKFALELNIDLQGSFFLETPNVCDLKAYLEGNQMTLR
What is the function of this protein?
Non-reducing polyketide synthase (NRPKS); part of the gene cluster that mediates the biosynthesis of aflavarin, a bicoumarin that exhibits anti-insectan activity against the fungivorous beetle C. hemipterus (Ref. 2, PubMed:26209694).  Catalyzes the formation of the aromatic polyketide from acetyl coenzyme A and seven malonyl coenzyme A molecules (PubMed:26209694).
What are the official names of this protein?
Non-reducing polyketide synthase afvB, NRPKS, Aflavarin synthesis protein B.
Protein: PCKG_STRCO
Sequence: MARDIAAPPVPTNHQELISWVNEIAELTQPDAVVWCDGSEAEYERLCGELVEKGTFRKLDPIKRPNSYYAASDPTDVARVEDRTFICSAKEEDAGPTNHWKDPAEMRAIFTGDKGEGGLFRGSMRGRTMYVVPFCMGPLGSPLSALGVEITDSAYVAASMRTMTRMGQPVLDELGDEGFFVKAVHSVGAPLEPGQADVPWPCNSTKYISHFPEDREIWSYGSGYGGNALLGKKCYALRIASVMARDEGWLAEHMLVLKLTPPTGAPKYVAAAFPSACGKTNLAMLEPTISGWTVETIGDDIAWMRFGEDGRLYAINPEAGFFGVAPGTGEHTNANAMKTLWGNSVFTNVALTDDGDVWWEGMTEETPAHLTDWKGNDWTPESGTPAAHPNARFTTPAAQCPIIAPEWEDPRGVPISAILFGGRRATAVPLVTESFDWNHGVFLGANVASEKTAAAEGKVGELRRDPFAMLPFCGYNMGDYMGHWVDVAKDKDQSKLPKIYYVNWFRKDDAGRFVWPGFGENGRVLKWIVERLEGRADGVETPIGVLPTKESLDTDGLDLADADLEFLLSVDKEVWREEAALVPEHLNTFGDHTPAELWDQYRALVRRLG
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_HAMD5
Sequence: MPRSLKKSFFVDRHLLKKVEKSAENNKDKKPIRTWSRRSTIFPEMIGLTIAIHNGRLHVPVFISDEMVSHKLGEFAPTRTYRGHVAADRKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: G1PDH_HYPBU
Sequence: MLHRIELPQKIVVGSGAIDALREVLEEFAGRNSSIAVISGPNVWRLYGERFRSIVEGFVEYSFFEARNASVEYAEKLLEDVKAYSPSLVVGFGGGKSIDLAKYVAYRLGVRMISVPTSPSHDGIASPFTSLKGLDKPHSVRTVTPAAIIADIDIIASAPIRLIRAGAGDLIAKLTAIRDWRLAHKLKGEYYGEYAAKLALLSAKHVIEYASQIGRGVKEAVRVLVEGLVSSGVAMCIAGSTRPASGSEHLFAHALDLIAPGKALHGEEVALGTIMMMYLHGGDWRHVRRTIRRLGLPVTAKELGLSDEVIVKALTMAHRIRPERYTILGESGLTWEAAERLARVTGVIG
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_COPPD
Sequence: MDVWVIGGGLAGSEAALTLADLGFPVTLFEMRPAVMTPAHKTSKLAELVCSNSLGSLSTDNAKGELLFELKVLGSSLVNLAFEAQIGGDKALVVDRELFSTLVEDAVRSHRNITVVRAEITEIPKDVPCIIAPGPLIKGDLLHFLEEREGRCEAQYYDATSPSILSETIDMDYAFWGNRFGEGSDYLNVPLSKEEYYWFVEQLLNAREAHRHDFDKPDAFFERCLPVEEIARRGKESLAFGPMRPTGLAIPEKFRDVHAVIQLRKENASGTILNMVGFQTGISHTEQISIFKQLPAFKNAVFVRLGQIHQNRFLPGVVNKFFQSRTNRLWFYAGQFTGTEGYLEAIAGGLWAGINVARLLGGEKLIPLPEESMLGGLVTYIEQSLPEVKQPMGVNWGLVPPVEGKKSERKQKRVDRARIAIEYAARELGRVT
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y402_STAAS
Sequence: MGYFKRVLLYIIVMVLSVFIIGCDKSSDTSEKSKGDSKEAQIKKSFAKTLDMYPTENLEDFYDKEGYRDGKFKKGDKGTWVIRSEMTTELKNENMVSKGMVIRLNRNSRTCTGEYFVRIVKEDSEGKVYSDERKYPVKMENNKIIPLKPIDDEKVKKEIEEFKFFVQYGNFKELENYKDGEVTYNPEAPIYSAQYQLKNSDYNVEQLRKRYNIPTQKAPKLLLKGSGNLKGSSVGYKNIEFTFVENKEENIYFTDSVYFNPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SAR0402.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: VFE66_ASFB7
Sequence: MLTMVSLARFIINTASFNKSIYPLSQVYVKIHLSHKYNHILFTYNMRIYLIKRNHMLFTHMLISCN
What is the function of this protein?
Inhibits host protein translation, probably through the EIF2AK2/EIF2S1 signaling pathway (PubMed:33328305).  Promotes cell retention in the G0/G1 phase (PubMed:33328305).
What are the official names of this protein?
host translation inhibitor E66L, pE66L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus E66L family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum.
Protein: RR12_TRICV
Sequence: MPTIQQLVRSRRIQIKKKTKSPALVNCPQRRGVCTRVYTTTPKKPNSAIRKVARVRLTSDLKVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGALDSVGVKDRTQGRSKYGVKKPKSDK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLPP_THEP1
Sequence: MTVKEKKIIDQYVPIVVESTGRYERAYDIFSRLLKDRIVFLGSPIDDYVANLVIAQLLFLEAEDPDKDVYLYINSPGGSVTAGLAIYDTMQYIKCDVSTICVGQAASMAAVLLAAGAKGKRYALPNARIMIHQPLGGAEGPAKDVEIITRELLRIKDLLNRILSKHTGQPIEKIEKDTDRDFFMSAEEAKEYGIVDKVVSTRE
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORN_BORPA
Sequence: MAANENRLVWLDMEMTGLDPEKERIIEVAVVVTEADLTVVAEGPVLVVHQPDSLLDAMDNWNKSTHGKSGLIEKVKASTLGEAQAEQILLEFLAEHVPAGKSPLCGNTISQDRRFMYAYMPNLERFFHYRNLDVSTLKELARRWAPAVYKGFDKKSRHEALADIYESIDELKYYREHLLKV
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD6_MOUSE
Sequence: MWLFLGIAGLLTAVLSGLPSPAPSGQHKNGTIPNMTLDLEERLGIRLVNGSSRCSGSVKVLLESWEPVCAAHWNRAATEAVCKALNCGDSGKVTYLMPPTSELPPGATSGNTSSAGNTTWARAPTERCRGANWQFCKVQDQECSSDRRLVWVTCAENQAVRLVDGSSRCAGRVEMLEHGEWGTVCDDTWDLQDAHVVCKQLKCGWAVKALAGLHFTPGQGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSEHQSWRLTGGIDSCEGQVEVYFRGVWSTVCDSEWYPSEAKVLCRSLGCGSAVARPRGLPHSLDGRMYYSCKGQEPALSTCSWRFNNSNLCSQSRAARVVCSGSQRHLNLSTSEVPSRVPVTIESSVPVSVKDKDSQGLTLLILCIVLGILLLVSTIFIVILLLRAKGQYALPASVNHQQLSTANQAGINNYHPVPITIAKEAPMLFIQPRVPADSDSSSDSDYEHYDFSSQPPVALTTFYNSQRHRVTEEEAQQNRFQMPPLEEGLEELHVSHIPAADPRPCVADVPSRGSQYHVRNNSDSSTSSEEGYCNDPSSKPPPWNSQAFYSEKSPLTEQPPNLELAGSPAVFSGPSADDSSSTSSGEWYQNFQPPPQHPPAEQFECPGPPGPQTDSIDDDEEDYDDIGAA
What is the function of this protein?
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166.  Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089).  Functions as costimulatory molecule; promotes T-cell activation and proliferation.  Contributes to the formation and maturation of the immunological synapse.  Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria.  Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria.  LPS binding leads to the activation of signaling cascades and down-stream MAP kinases.  Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
What are the official names of this protein?
T-cell differentiation antigen CD6.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with the TCR/CD3 complex at the immunological synapse.
Protein: GLO2_RHOP2
Sequence: MAADIRIVPCLTDNFGYLIHDPSSGATASIDAPEAAPLIAALEKEGWKLTDILVTHHHGDHVGGIAELKAKYHCRVVAPHDANAKIADADLRVEEGDVVKVGGLEARVLETPGHTLDHISYVFADDRALFAADTLFSIGCGRVFEGTYPMMWESLLKLRALPDDYKLYCGHEYTASNVKFALTIEPENAALQARAKQVEQQRGAGRPTIPVTLGEEKQANVFLRADVPSVAAAIGFAGESAADVFGELRERKNNS
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: RSMJ_BUCAI
Sequence: MKIYLKFKSYNKRICKLLQLFKLEHDQNCSMGLLINHNSLELYNRDNVNQKPIKVDFTSKKNHYRCHHFRRKNEVLYRVSGIKNSYFPTILDATAGLGNDAFIFSFLGCKVIMIERHPIVAALLKDGLQRGYQDKKIGHWLQTRLHLIVNDSLKMLEIPILQPDVIYLDPMYPFHHKKSLPKKDMQFFRQLIGHNYDSKKLLEVSRKLAKNRIIVKRPYYAKPLSEDKVNHIVTTRNHRFDIYQPF
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMW2_MYCPN
Sequence: MNDTDKKFPLQPVYDTGFDDGYLQRDYEKCLESAAANDAQTVELQTQLLAEIKNLENEIKALKAQESRQPDPHNNARIQSLEASLNRLVNEYNNFEFQKNYMVDRVAELNNKARFFKDELKRLQQENAAFVNSRYANWADFQSNYQLKLDQFQALIDQQNQTIKQLNEQIAANQGLIDQNVQRLQQNHSLDQQERDALLYEVDHLYNELYELENQKRLVGIEYEATYQDLVSADAELQNVYETIAQNQANFQKQCDAYWAQLKQVEQQIQTTKQELVDEESTLKVRLNDADFYINSRLAELDDLTSKINERDFVSKEQAQDVKASLANLTKEKERLSAEKDSFERLRNTALNDINRMEQENALFAKHLEQQQYEFERKQQESLLKLETEHKQLQKRIGEFKIESEAKSEALLIQERELLEKRREIDDLLTQASLEYEQQRRTNQVLKEKHRQVQQHFQNLVHAKKKLDQKRHYLAEQKRIDEEQIFKLKEKIATERRELEKLYLVKKQKQDQKENDLLIFEKQLRQYQADFENEIEEKQNELFASQKSLQKSFTQLKNKEAELNQKAQKIAEDWAHLKQNKHHHADLEIFLEGEFNHLQQEKHKLLEARTQFDNRVSLLSARFKQKQAELVKQKQSLEQLTAAFNKEQEAVERDWKDRLANLEKQKEMLGDKVHQFDENSLNISKKLAERELAIKFKEKELEAAQKQLSLDNNNNAGLKLQLDKLSESLKTERLELEASKERILDFYDESSRRIADYESDLQARLAEVKTLEKNQQETAAKSERELKVALEKLNQAKKAFLQIRKQQLLEIASVKQQLAQKANLLKNQQAELDKQTEELEAAFLEQDTDKKELEKALHSVKSKQELLERERSFLLQKQREFAEHVAGFKRQVHFKTTQMQRLSEFNKQQQSEQIKRETELKIAFADLKKDYQLFELQKNQEFQQIEQKHKELELLAQKQAELKQELEQKATALASQDQDTVQAKLDLARQQHELELRQNAFNQASLSLNKQREQLTNQVKVLHGELKKRHEKLTLKDRLLAEKEKDQHKKDAEINQRFKQFENEYADFDQAKKRELQELNQIRRNLEQSNASLLKKRNQLTLDFALLRKVQHNTQTNRVQLNTQIKEFLLEKKNFQKASDEAALQKALLIKRLRSFASKLQLQREALAIQKLEFDKRDEQQKSEINNAKLQLEQFKLEKQNFDEAKQKQLIEFKDQCQRLDVEKRLLKQKLVQLKNLSKSYLTYKNRADLSQQQLQHKYANLLELKEKLQTAKRALDKKHRAIYGKMAQFVSELRQEKKQLLSAQKQVDDKSRLLEQNQRHLQNLSSETKKKRQSLEHDINKFDQRRKEAVSSILNSHKKLKQKEGELQGILQKLSLKKTQIEQEFSKLYQQREKLDRQRTTLSKLHRELKAQNEATAHKNREVLEIENYYKKELQRLTTEKSEFDNNKNRLFEYFRKIRNEIEKKEAHIKTVLEETQKKRHLVETEAVKLHLQKQSIISKGQELKEIKERVSRDISHTNKQREELNSLLHQNKLLQKNLAEREREINNKDSLLTQKIQTAKQKLSEKEARILKLLEKMRAVEQQYQAEITRLKTRNADLEKNDNKHLFPPLFKINGNDMNYPYPYPWFYPQQKQEDSSNQIRHLFEQQLQFMQQRYENELTELRRQRALLEKKLDQIQLESQLSAKKNDFEKVEQMMQKLLEKTEQKLSAFDQKINALAEQINTQKAEHADSEKQQLLLRIEQLEKQNLAQAVQTPQPVQPVVQAPAVVPQVIQPQVVQSQPAFLATQQSISKQQQIAQLNAEINSIKKLIAQKAAK
What is the function of this protein?
Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma.  This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity).
What are the official names of this protein?
Cytadherence high molecular weight protein 2, Cytadherence accessory protein 2.
Protein: SYR_CAMJJ
Sequence: MKSIIFNEIKKILECDFALENPKDKNLAHFATPLAFSLAKELKKSPMLIASDLASKFQNHDCFELVEAVNGYLNFRISKTFLNELANQALTNPNDFTKGEKKQESFLLEYVSANPTGPLHIGHARGAVFGDTLTRLARHLGYKFDTEYYVNDAGNQIYLLGLSILLSVKENILHENVEYPEQYYKGEYIADLAKEAFEKFGKEFFSEENIPSLADWAKDKMLVLIKQNLEQVKIKIDSYVSERSYYDALNATLESLKEHKGIYEQEGKIWLASSQKGDEKDRVIIREDGRGTYLAADIVYHKDKMSRGYGKCINIWGADHHGYIPRMKAAMEFLGFDSNNLEIILAQMVSLLKDGEPYKMSKRAGNFILMSDVVDEIGSDALRYIFLSKKCDTHLEFDISDLQKEDSSNPVYYINYAHARIHQVFAKAGKKIDDVMKADLQSLNQDGVNLLFEALNLKAVLNDAFEARALQKIPDYLKNLAANFHKFYNENKVVGSANENDLLKLFSLVALSIKTAFSLMGIEAKNKMEH
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAPK3_RAT
Sequence: MDGETAGEKGSLVPQPGALGAPALGGAPAPGVRREPKKYAVTDDYQLSKQVLGLGVNGKVLECYHRRSGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRILDVYENMHHGKRCLLIVMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSQNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPKPEWADVSEDAKQLIRLLLKTDPTERLTIMQFMNHPWINQSMEVPQTPLHTARVLEEDKDHWDDVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQGGSSSASPGCNNQ
What is the function of this protein?
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation.  Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates.  Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue.  MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2.  Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36.  Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively.  Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs.  Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript.  Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.  Also acts as a modulator of Polycomb-mediated repression (By similarity).
What are the official names of this protein?
MAP kinase-activated protein kinase 3, MAPK-activated protein kinase 3, MAPKAP kinase 3, MAPKAP-K3, MAPKAPK-3, MK-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
Protein: EPFL3_ARATH
Sequence: MEYMFLLMSKFFFVFPIIIYIGPAEIIKPQAAEENSRRRILNPNENKEEIVKRRRRIGSKPPSCEKKCYGCEPCEAIQFPTISSIPHLSPHYANYQPEGWRCHCPPP
What is the function of this protein?
Controls stomatal patterning.
What are the official names of this protein?
EPIDERMAL PATTERNING FACTOR-like protein 3, EPF-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SEMG2_HYLKL
Sequence: MKSIILFVLSLLLILEKQAAVMGQKCGSKGQLPSGSSQFPRGQKGQHYSGQKDEQHTKSKGSFSIQHTYHVDINDHDRTQKSQQYDLNAQHKMTKSKQHLGGSQELLNYKQEGRDHDKSKDHFHMIVIHHKGGQAHRGTQNPSQDQGNSPSGKGISSQYSNTEKRLWVHGLTKEQASASGAQKGRTQGGSQSSYVLQTEELVANKQQRETQNSPQNKGHYQNVVEMREEHSSKLQTSLHPAYQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLNQDQEHGQKTHKISYQSSRTEERQLNRGEKSVQKDVSKGGISIQTEEKIHGKSQNQVTIHSQGQEHGHKENKMSYQSSSTEERHLNCGEKGIHKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEHGHKENKMSYQSSSTEERRLNYGGKSMQKDVSQSSTSFHTEKLVEGKSQIQTPNPNQDQWSVQNAKGKSDQSAGREQDLLSHEQKGRHQQESSEARNIVITEHEVAYDDHLTQQYNEDRNPVST
What is the function of this protein?
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
What are the official names of this protein?
Semenogelin-2, Semenogelin II, SGII.
What is the protein family that this protein belongs to?
Belongs to the semenogelin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEM3_STAA3
Sequence: MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSLKDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTEDYDAIILAAAGLRRMGWSDDIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGSCQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEIIKRLNEQH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: ENO_PHYAS
Sequence: MPYIKTINSLEVLDSRGNPTVEVEVITLSGAKGKTLVPSGASTGEHEAVELRDSDSKRYLGKGVLKAVENVATVIEPRLQNLSVLDQALIDQTLIQLDGTPNKSKLGANAILGVSLACARAAADYLGLELYEYIAGIAPKQMPVPMMNVINGGAHASNSVDFQEFMILPTGAPSFKEALRYGAEVFHHLGKILKQKGLPTTVGDEGGYAPDLNSNKEALQIILEAIQNAGYVPGKDIFLGMDVAASEFYDRETKKYLLASENNKTFSSEELVSYYEQLINKYPILSIEDGLDQNDWDGWKLLTQKLGQKVQLVGDDLFVTNTQKIQEGIDKQIANSVLIKLNQIGTLTETLEAIEMAKKASYTVVISHRSGETEDTTIADLAVAMNTGQIKTGSCSRTDRIAKYNQLLRIEKNMSNPSYLGLKVFYNLKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SAR1_CANGA
Sequence: MVWDVFGWFRDVLASLGLWNKHGKLLFLGLDNAGKTTLLHMLKNDRLATLQPTWHPTSEELAIGNIKFTTFDLGGHVQARRLWKDYFPEVNGIVFLVDSADPDRFDEARVELDALFNITELKDVPFVILGNKIDAANAVSEAELRSALGLLNTTGSQRIEGQRPVEVFMCSVVMRNGYLEAFQWLSQYI
What is the function of this protein?
Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.  SAR1 controls the coat assembly in a stepwise manner.  Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex.  These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles.  Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity).
What are the official names of this protein?
Small COPII coat GTPase SAR1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. SAR1 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.