PharMolix/UniProtQA huggingface dataset:
Protein: PROB_TERTT
Sequence: MSKRQLVTQSRRFVIKIGSALLTDNGRGLDQKAMAAWVEQIAALSKKGYEVVLVSSGAVAAGMTRLGWKSRPKAIHEQQAAAAVGQSLLIQAYEQEFQRYSKKIAQVLLDHDDLSSRQRYLNARSTLRTLMNLDVIPIINENDTVVTDEIRFGDNDTLAALVANLIEADILCILTDQKGMFDSDPRQNALAELLFEKPALSPELDNMATSGGALGRGGMISKVRAARLAARSGASTVIVGGKIPDVLPKVANGDMIGTLLYADQQPIAARKRWLAGQLQSRGVVTLDDGAVSVLRDKGKSLLPVGVKAVSGHFTRGDMVVCKDARGAEIARGLVNYNSDDARKIMGQPTTKIETLLGYKDFDELIHRDNLVLS
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDP_SALTY
Sequence: MDELTAQALKAFTTRYCDAWQEKHGSWPLSEELYGVPSPCIISSTRDAVYWQPQPFEGEENVNAVERAFDIMVQPALHAFYTTQFAGDMPAQFADEKLTLLQTWSQDDFRRVQENLIGHLVTQKRLKLPPTLFIATQENELEVISVCNLSGEVIKETLGTRNRTVLAATLAEFLTQLNPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: NDUV1_SCHPO
Sequence: MLSRGHCCKLKHSFNGLRNVALKRLVGSKAGYRMFPNLIEKRIRRIDDALADGEYENLSEILKYDPLNIIELVQESELRGRGRYGFPTGEKMLSLYKATSSERGRKEKPVVIVNAAENDIGSFKDRLLLRHEPHKIIEGAIIAARAVEASACYLFIRKDYYEETVMMQKCIIQAYAKKLLGKNLLGTSIGLELLIHPGAGSYITGEESALIQSLQGEFPVPDIPINNTITSGLFGLPTLVLNVETVSNLPAIIKKGPKFFISMGRPNNRGTKLFSISGEVNEPNVIEACMSIPLKDLIENYAGGVRGGWNKLVGIFPGGPCSGILNKNQCEQVTMDFDSLKALDSSLGTGSVIVLNDHDQIFESLLNFAKFYSTNTCHTCPVCRDGVEDVIETLKGLKDGHAHLSQLKDMFSKFNMPSSSKVFCGFGDSMRHQIHSIQRNFPDQITFRTKVT
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 51 kDa subunit homolog SPBC18E5.10, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the complex I 51 kDa subunit family.
Protein: PTCD2_XENLA
Sequence: MAVLGSWTAQRCLWENGGRSLLRAVAQSGPCCSHQAKRYLLTDDILKLHEFQKKKLATLYQIYGKKDLYFQMIEDKLQRNGIILRDELKTLLHLCSTQPDVEFAKRVIYRYHAENKNVMFGEFRFGPVFLRLCYELDLEDIALDLLKDQTLRGFFSDCTSFNILMDMLFTKGQYERAVEVLVEMRNQRVRFSKDTYILAFAVCYKLNNPNSCKICTTLLEEIEMTGDLLPKQAACFAAAFALKQNEFQRARTIYSKIMNTDTKLCNNLLLLIKVHTSTMEDVLHFLEAATGTTGSILVKKLEFSEEVLASAGQKLKSQAELHTRFNSVYQRLKNEGQISALTLDQMLCYTSPELRHTNAHLLRNRKISHRTFRSLQSTLLVE
What is the function of this protein?
May be involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.
What are the official names of this protein?
Pentatricopeptide repeat-containing protein 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PTCD2 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RIPP1_MOUSE
Sequence: MDPAASPAAAPPAAPAAAPAADPAADPAAALPGQALAQAPALAQINGQEGARNERAAYLWRPWLSSINDQPRQARSLVDWADNRATAAEAAKTDSDFHHPVRLYWPKSHSFDYLYSAGEILLNNFPVQATINLYEDSDSADNEEDKEEEEEEEEEEDDEEEEEDEDKDVNENEPEVCMGVSEATTHKATAHSPDPHSACPN
What is the function of this protein?
Plays a role in somitogenesis.  Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity).
What are the official names of this protein?
Protein ripply1.
What is the protein family that this protein belongs to?
Belongs to the ripply family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLPK_STRP3
Sequence: MSQEKYIMAIDQGTTSSRAIIFNQKGEKVSSSQKEFPQIFPHAGWVEHNANQIWNSVQSVIAGAFIESSIKPSQIEAIGITNQRETTVIWDKKTGVPIYNAIVWQSRQTAPIAEQLKQDGHTKMIHEKTGLVIDAYFSATKIRWILDHVPGAQERAEKGELLFGTIDTWLVWKLTDGAVHVTDYSNAARTMLYNIKDLTWDDEILELLNIPKDMLPEVKSNSEIYGKTAAFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGDEMQLSSNNLLTTIGYGINGKVHYALEGSIFIAGSAIQWLRDGLKMIETSPESEQFALASTSDDEVYVVPAFTGLGAPYWDSNARGSVFGLTRGTSKEDFVKATLQSIAYQVRDVIDTMQVDSGIDIQQLRVDGGAAMNNMLMQFQADILGIDIARAKNLETTALGAAFLAGLAVGYWEDMDALKELNATGQLFKASMNESRKEKLYKGWKRAVKATQVFTQEEDADDDAK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: FENR_STRS2
Sequence: MTQVYDITIIGGGPVGLFAAFYAHLRQAKVKIIDSLPQLGGQPAILYPEKAILDIPAFPSLTGQELTDNLLAQLAPFDTTICLNETLTAIEPGETITLTTNKGNHQTKTLIIAMGGGAFKPRPLEIDGADSFDNVHYHVSNIQQYADKDIVVLGGGDSAVDWSLAFEKIAKTTQIIHRRDNFRALEHSVEELKQSSVTIHTPFIPKGLSGENGRASAIDFDKVKSEDKLTLSFDHLFVNYGFKSSVGTLKEWGLELNRHRIVVNSKQETSVPGIYAIGDCCFYEGKIDLIATGLGEAPTAVNNAMNYLNPNEKVQPKHSTSL
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: SPP2A_MOUSE
Sequence: MGLLHSLHAPAAALLWSCLLGLAAAQEAILHASTNGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTALCHLSDIPPDGIRNKAVVVHWGPCHFLEKARIAQEGGAAALLIANNSVLIPSSRNKSTFQNVTVLIAVITQKDFKDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELENMKSVEDAEDRETRKKKDDYLTFSPLTVVVFVVICCIMIVLLYFFYRWLVYVMIAIFCIASSMSLYNCLSALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKLPVVIRVPKLMGYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITVSVVAWSRKEMKKFWKGSSYQVMDHLDYSTNEENPVTTDEQIVQQ
What is the function of this protein?
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.  Functions in FASLG, ITM2B and TNF processing.  Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus.  Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD).  Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system.  Plays a role in the regulation of innate and adaptive immunity.
What are the official names of this protein?
Signal peptide peptidase-like 2A, SPP-like 2A, SPPL2a, Intramembrane protease 3, IMP-3, Presenilin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22B family.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
Protein: 3HAO_XANOR
Sequence: MLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMIVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQDDGVARDIPIRAGEIFLLPPRVPHSPQRAAGSIGIVIERVRLPHEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDHFYRSLALRTCSQCGHLHPAPERYAAVED
What is the function of this protein?
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
What are the official names of this protein?
3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HAD.
What is the protein family that this protein belongs to?
Belongs to the 3-HAO family.
Protein: QUEA_BURP6
Sequence: MLTLSDFDFDLPPELIAQTALPERSASRLLEVDNTNPSAPPRLVDRRFAELPACVAPGDLLVFNDTKVLKARFFGRKASGGKIEVLIERVTGERTALAQIRASKSPPPGTTLTLADAFDVTVGERVEPFFTLHFPDDCLVLIERHGRLPLPPYIEHAPDAADETRYQTVFAANPGAVAAPTAGLHFDDAVLAALEARGVERATLTLHVGAGTFQPVRVENLAEHRMHSESYELTDALVEKIAATRARGGRVIAVGTTSMRALEAAARDAQAAGRPLAATRAETDIFITPGYRFRVVDRLVTNFHLPKSTLLMLVSAFAGIETIRAAYRHAIDARYRFFSYGDAMLLTRRDDAAEATHGGA
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_AGARV
Sequence: MKKISILGSTGSIGTQTLDVIREHGDMQVVALSCGRNLSLIEKQAREFKPQFVSVSDENDAKKLRTSLADTDIEVGYGMDGLIRCATIEPCDIVVTAIVGMLGIRPTIAAIKAKKTIALANKETLVTAGHIIIPLAKEYGVSILPVDSEHSAIFQSLQGNSMNPIKKILLTASGGPFRGRKLSELEGIRVEDALKHPNWSMGQKITIDSSTMVNKGLEVIEAKWLFDVDLSQIQVVVHPQSVIHSAVEYADGAVIAQLGTPDMRIPIQYALYYPSRPALSGDRLDLFKLKDLTFEAPDLDTFKGLALAMKAARAGGNIPTAFNAANERAVALFLNKKIKYLEIIDIIEACMENASFIENPSVDEILDTEQCAYDYISKRW
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: HLDD_NEIM0
Sequence: MTIIVTGAAGFIGSNIVKALNQRGITDIVAVDNLSKGEKFKNLAECEIAHYLDKHEFIRQVREHILPYQNIEAVFHQGACSDTMNHDGLYMMDNNYQYTLDLLDWCQDERIPFLYASSAAVYGKGEIFREERELEKPLNVYGYSKFLFDQVLRRRMKEGLTAQVVGFRYFNVYGQHEQHKGRMASVAFHHFHQYREHGYVNLFGSNDGYGNGEQTRDFVSVEDVAKVNLYFFDHPELSGIYNLGTGRSQQFNELAAATVNACRAAEGKPEMSLKELVEEELIRYIPFPDALKGKYQSFTQADITKLREAGYTEEFFDVKSGVERYVKWMLENLA
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: O2AG1_HUMAN
Sequence: MELWNFTLGSGFILVGILNDSGSPELLCATITILYLLALISNGLLLLAITMEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGGAEDLLLAFMAYDRYVAICHPLTYMTLMSSRACWLMVATSWILASLSALIYTVYTMHYPFCRAQEIRHLLCEIPHLLKVACADTSRYELMVYVMGVTFLIPSLAAILASYTQILLTVLHMPSNEGRKKALVTCSSHLTVVGMFYGAATFMYVLPSSFHSTRQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVLGKYMLPAHSTL
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2AG1, HT3, Olfactory receptor 2AG3, Olfactory receptor OR11-79.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: XYNA_CLOSA
Sequence: MLRRKVIFTVLATLVMTSLTIVDNTAFAATNLNTTESTFSKEVLSTQKTYSAFNTQAAPKTITSNEIGVNGGYDYELWKDYGNTSMTLKNGGAFSCQWSNIGNALFRKGKKFNDTQTYKQLGNISVNYDCNYQPYGNSYLCVYGWTSSPLVEYYIVDSWGSWRPPGGTSKGTITVDGGIYDIYETTRINQPSIQGNTTFKQYWSVRRTKRTSGTISVSKHFAAWESKGMPLGKMHETAFNIEGYQSSGKADVNSMSINIGK
What are the official names of this protein?
Endo-1,4-beta-xylanase, Xylanase, 1,4-beta-D-xylan xylanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 11 (cellulase G) family.
Protein: NEK6_ARATH
Sequence: MDDYEVVEQIGRGAFGSAFLVIHKSERRKYVVKKIRLAKQTERCKLAAIQEMSLISKLKSPYIVEYKDSWVEKDCVCIVTSYCEGGDMTQMIKKSRGVFASEEKLCRWMVQLLLAIDYLHNNRVLHRDLKCSNIFLTKENEVRLGDFGLAKLLGKDDLASSMVGTPNYMCPELLADIPYGYKSDIWSLGCCMFEVAAHQPAFKAPDMAALINKINRSSLSPLPVMYSSSLKRLIKSMLRKNPEHRPTAAELLRHPHLQPYLAQCQNLSPVFKPVVSKSEHNTNENRTGLPPKTKSAKTPIKHNQESEETEKKNKDTSSSSKDKERPAKSQEMSVISTLTLLREFQKKSPKSEERAEALESLLELCAGLLRQEKFDELEGVLKPFGDETVSSRETAIWLTKSLMNVKRKQNDDETNI
What is the function of this protein?
May be involved in plant development processes.
What are the official names of this protein?
Serine/threonine-protein kinase Nek6, NimA-related protein kinase 6, AtNek6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Protein: CHI6_POPTR
Sequence: MSVWALFAFFSLFLSLSVRGSAEQCGRQAGDALCPGGLCCSSYGWCGTTVDYCGIGCQSQCDGGGGGDGGDDGCDGGDDGGGDGDDGYLSDIIPKSKFDALLKFRNDARCPAAGFYTYNAFISAAKEFPDFGNTGDDLMRKREIAAFLGQTSHETTGGWPDAPCGPYAWGYCYLKEINCQPYCDPSSNYQCVAGKQYCGRGPIQLSWNYNYGLCGDDLKLPLLQEPELVETDPVISFKTAIWFWMKPQSPKPSCHAVITGNWTPSAADLEAGRVPGYGVITNIINGGIECGQGGPNAANEDRIGFYKKYCDSLGTTYGSNLDCYQQRPFGYGLSGLKDTM
What is the function of this protein?
Defense against chitin-containing fungal pathogens.
What are the official names of this protein?
Acidic endochitinase WIN6.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
Protein: RS11_NEIMB
Sequence: MAKANTASRVRKKVRKTVSEGIVHVHASFNNTIITITDRQGNALSWATSGGAGFKGSRKSTPFAAQVAAEAAGKVAQEYGVKNLEVRIKGPGPGRESSVRALNALGFKITSITDVTPLPHNGCRPPKKRRI
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: CD81_RAT
Sequence: MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTTLLYLELGDKPAPSTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGSNTLTTLTTAVLRNSLCPSSSNSFTQLLKEDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
What is the function of this protein?
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling.  Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells.  Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production.  In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype.  Present in MHC class II compartments, may also play a role in antigen presentation (By similarity).  Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes.  Positively regulates sperm-egg fusion and may be involved in acrosome reaction.  In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity).  In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity).  Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity).  May regulate the compartmentalization of enzymatic activities.  In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (By similarity).  Also involved in cell adhesion and motility.  Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity).
What are the official names of this protein?
CD81 antigen, 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Protein: PCKA_BRUSU
Sequence: MKETGIHNKAASISTSGLKELSAVFYNLGPARLYEETIRRGEAELSAQGALVARTGQHTGRSPKDKFVVRDANTEDHVWWDNNKPMTPEAFELLYADFIEHAKGRELFVQDLIGGADADNKINARVITEYAWHSLFIRNLLIRPSQEALASYVPEMTIIDLPSFKADPERYGVRTETVIAVDLTRKIVLIGGTSYAGEMKKSVFTALNYILPAKGVMPMHCSANEGPNGDTAVFFGLSGTGKTTLSADPTRTLIGDDEHGWGEHGVFNFEGGCYAKTIRLSAEAEPEIYATTQRFGTVLENVVLDENRQPDFDDGSLTENTRCAYPLDFIPNASKSGKGGQPKNIIMLTADAFGVMPPIAKLTPAQAMYHFLSGYTAKVAGTEKGVTEPEATFSTCFGAPFMPRHPSEYGNLLRKLIAEHKVDCWLVNTGWTGGAYGVGKRMPIKATRALLAAALDGSLNNAEFRIDPNFGFAVPVEVPGVESSILDPRSTWADKVAYDAQAKKLVDMFVSNFEKFESHVDHEVKDAAPAIRMAAE
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NGLY1_CAEEL
Sequence: MPVTEVGSLPELNNILERSDANRLIIIDFFANWCGPCRMISPIFEQFSAEYGNATFLKVNCDVARDIVQRYNISAMPTFIFLKNRQQVDMVRGANQQAIAEKIRQHYSPTPANPNAASDSEKRFLEQFVKCSNVPRSYQDEVFKALARSVMPEELVGRAMTEGPRDEKAILKDLLHWFKTQFFTWFDRPTCPKCTLKCSTDGLQGTPTREEQKEGGASRVEVYICDGCNTEMRFPRYNNPAKLLQTRTGRCGEWANCFGLLLAALNLESRFIYDTTDHVWNEVYLLAEQRWCHVDPCENTMDRPLLYTRGWGKTLGYCIGYGSDHVVDVTWRYIWDSKKLVTQRNEVRQPVFENFLSKLNSRQAEGQTEPRKRELAVRRVCELMEMMAQEAKNHKIGWEKIGDDLGGRITGSEEWRRERGELGESGPKLLAEPIKLAPPTGPAQNYLEFNYDVITDTYSQPPEIGFSAQAFELENVQRVEETDWNMTYLCRKRGDAPGNISWHFDLKSLKKSIEKIEIRMAGIQKFEKGKAMAIACLGDSCMRLPIDCSALTIEDPKNAEILKITATLSGGEGAIGFQQAQIFRTELKRGGGARTESFSVKIWMKN
What is the function of this protein?
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation (PubMed:17509531, PubMed:17522090).  Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp (PubMed:17522090).  Prefers proteins containing high-mannose over those bearing complex type oligosaccharides (PubMed:17522090).  Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins (PubMed:17509531).  Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (PubMed:17509531).  Also displays oxidoreductase (thioredoxin) activity (PubMed:17509531, PubMed:17522090).  Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction (PubMed:27528192).
What are the official names of this protein?
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, Peptide:N-glycanase, PNGase.
What is the protein family that this protein belongs to?
Belongs to the transglutaminase-like superfamily. PNGase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Note=ER localization inferred from partial colocalization with an ER marker, membrane protein PIG-X.
Protein: Y2253_CHRVO
Sequence: MHIQEFHQALADIGARPCHIGRINRAWLKGLPLDAGTRHQKSEDYFPLSVREGLAPIAARIEKLARIHSRHDADDGSLRLLVGLGDGQMVESVLLPRDGLCVSSQVGCAVGCTFCMTGKSGLLRQLGSAEIAAQVALARRIRPVKKVVFMGMGEPAHNMENVLEAIQWLGTDGNIGHKNLVFSTVGDARVFERLPQLEVKPALALSLHTTRADLREQLLPRAPRIAPAELVELGEAYARRVGYPIQYQWTLLAGVNDSQEEMDAAARLLKGKYGVLNIIPYNSVEGDRFQRPSSERVQAIKRYLHDNGVLTKVRDSAGQDVDGGCGQLRARAAHVIDASRLRRREQAGVSAG
What are the official names of this protein?
Probable RNA methyltransferase CV_2253.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LST4_CAEEL
Sequence: MAQVKAEYDFQSQPNTGELSISAGEVLTVIRENIDGGWIEGRNVRGSVGLFPESYVTPYQASRPPPVLPPPLPPTSSGPPAASSRPFDDWGGASEVAAPPSYGAQHHHQPTPSVPEVTRSSYPSQNDDFDDEWTDEDDEQEPTRPNVQSSIGSNSRRDLSRSHSEHGGPDRGSNKVNKNINRFSNFVKSGVEAYVIGESKTTSQISERHEVVMNNGIIQWKPIQQYYTCIVDKPKKESKLKGLKSFIAYSITSSLTNIQRQVSRRYKHFDWLHEQLSAKYVLIPIPPLPEKQVAGRYEEDLIDHRKHILQLWVNKICRHPVLSQSEVWLHFISCTDEKDWKNGKRRAEKDEYIGGAFLNCITVPHQPLDPNNVDMQVERFQRSVKTSEEAMRVMQERMNMFQKVFAGPVKQNWQKMGSAFKTLQQSFEIDETVASRRLTEALAYTASEYHEIGQVFDAHTKNDMEPVLENLYSYKGTVQNVPDIIQVHKQAVQKFRDSEGRLSSAEAEKMKQRIDAMSYTVIAEVQHQTAEKVEDMKSTMGTYLKKQAMFYQEVATKLTSLAARYD
What is the function of this protein?
Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling.  Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes.  Also recruits rab-7 to phagosomes by an interaction with dyn-1.  These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance.  Binds phosphatidylinositol-3,4,5-trisphosphate.
What are the official names of this protein?
Sorting nexin lst-4, Lateral signaling target protein 4.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, phagosome membrane. Note=Recruited to phagosomal surface by phosphatidylinositol trisphosphate. BAR and PX domains are required for the phagosomal localization.
Protein: KBTB1_HSPV
Sequence: MNSSSKLIAVINGFRNSGRFCDINIVINDERINAHKLILSGASEYFSILFSNNFIDSNEYEVNLSHLDYQSVNDLIDYIYGIPLSLTNDNVKYILSTADFLQIGSAITECENYILKNLCSKNCIDFYIYADKYNNKKIESASFNTILQNILRLINDENFKYLTEESMIKILSDDMLNIKNEDFAPLILIKWLESTQQPCTVELLKCLRISLLSPQVIKSLYSHRLVSSIYECITFLNNIAFLDESFPRYHSIELISIGISNSRDKISINCYNHKKNTWEMISSRRYRCSFAVAVLDNIIYMMGGYDQSPYRSSKVIAYNTCTNSWIYDIPELKYPRSNCGGLADDEYIYCIGGIRDQDSSLTSSIDKWKPSKPYWQKYAKMREPKCDMGVAMLNGLIYVIGGIVKGDTCTDALESLSEDGWMKHQRLPIKMSNMSTIVHDGKIYISGGYNNSSVVNVISNLVLSYNSIYDEWTKLSSLNIPRINPALWSTHNKLYVGGGISDDVRTNTSETYDKEKDCWTLDNGHVLPRNYIMYKCEPIKHKYPLEKTQYTNDFLKYLESFIGS
What is the function of this protein?
Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins.
What are the official names of this protein?
Kelch repeat and BTB domain-containing protein 1.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: RR8_AGRST
Sequence: MGKDTIADLLTSIRNADMNKKGTVRVVSTNITENIVKILLREGFIESVRKHQERNRYFLVSTLRHQKRKTRKGIYRTRTFLKRISRPGLRIYTNYQGIPKVLGGMGIAILSTSRGIMTDREARLNRIGGEVLCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.