PharMolix/UniProtQA huggingface dataset:
Protein: RUVA_MYCGI
Sequence: MIASVRGEVLDIALDHVVIEAAGVGYKVMATPATLATLRRGSEARLITAMIVREDSQTLYGFADSDARDLFLTLLGVSGIGPSIALGALAMYDGPTLRQAIGDGDLTALTRIPKVGKKTAELLALTLRDKVGSSTSSGVAAAGGHGIRGPVVEALVGLGFAVKQAEEATDKVLANDPEATTSSALRAALSMLGKK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: DEOC1_STAAC
Sequence: MKFEKYIDHTLLKPESTRTQIDQIIDEAKAYNFKSVCVNPTHVKYAAERLADSEVLVCTVIGFPLGASTTATKAFETEDAIQNGADEIDMVINIGALKDGRFDDVQQDIEAVVKAAKGHTVKVIIETVLLDHDEIVKASELTKAAGADFVKTSTGFAGGGATAEDVKLMKDTVGADVEVKASGGVRNLEDFNKMVEAGATRIGASAGVQIMQGLEADSDY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase 1, DERA 1, 2-deoxy-D-ribose 5-phosphate aldolase 1, Phosphodeoxyriboaldolase 1, Deoxyriboaldolase 1.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VILL_MOUSE
Sequence: MDINQDLPAIDSHRALQIWITENLKMLPLPERAHGNFFEECCYVVLHVPQSPKATQGGSSDLHYWIGKDASAEAREAAVSFVQCLQEDLGDQTVLHRESQGHESDCFHSYFHPGVIYRKGGRDSALKFAETNMYNVQRLLHIKGRKHVSATEVALSWNSFNKGDIFLLDLGKVMIQWNGPKASISEKARALTLTCNLRDRERGGRAQIAVVDAENEATNLLRIMEAVLGCRSGSLCPSVPSNSVSQLQKANVRLYHVCEKGTDLVVQELATRPLTQDLLQEDGCYLLDQGGFKIYMWQGRKSSPQEKKAALSRAVGFIQAKGYPNYTNVEVVNDGAESTAFQQLFWSWSKELDRKKHPEKSKLVQGNLEVGKLHTQPELAAQLRMVDDGSGKVEVWYIQDLQRQPVHPKYYGQLCSGNCYLVLYTYQKLGCVQYLLYLWQGHQSTVEDTKALNCSAEELDLMHQGALAQGHVTMGSEPPHFLAIFQGRLVVFQGNAGNKGERPPVSDTRLFHVQGTESHNTRTMEVPARASSLTSGDVFFLITSHVCYLWFGKGCHGDQREMARTVVSVFPGNNKETVLEGQEPLYFWEALGGRAPYPSNKRLPEEVWSIQPRLFECSSHAGCLVLTEVLFFGQEDLDKYDIMLLDTCQEIFLWLGEAAGEWKKEAVAWGLEYLRTHPAERSLATPIFVVKQGHEPATFTGWFVTWDPYKWMNSQSYEEMVGNSLGPGSAISEMTAEVHNFQLTPRLSDNKAGHPALQAFKGSQDSPENELGLDLRVDGANPSMNHTSSCSDSMVNGSLPRERLMHQALEDLPPGVDPARKEFYLSDSDFQDIFGKSKEEFYSMAKWKQQQAKKKLGFF
What is the function of this protein?
Possible tumor suppressor.
What are the official names of this protein?
Villin-like protein, EF-6.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
Protein: SSRP_SHEHH
Sequence: MAKKNAKNSKNSSASIARNKRATFDYKFEEKLEAGLSLMGWEVKSIRMGKVNLSESYVFLREGEAYLFGCTIAPLNTASSHVVCDPLRSRKLLLKRKELDKLQGLVDRKGYSIVPISMYWQKGAWVKIEIGLGKGKKEHDKRDDTKDREWQIEKARTIKKAVQQ
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: YL159_YEAST
Sequence: MYSCAKKKTTAAPEFRVWSPTTLLGQALTSLTTVDRTGNGAFW
What are the official names of this protein?
Uncharacterized protein YLR159C-A.
Protein: CHA5_LYMDI
Sequence: MNSFALLLVCIQACLVQSVFSQCTSRAAVAADRGIIGGYGLGAPCGLGYGLEAPYGWAGYADYGYPAGAYGIDAYGGIGEGNVAVAGELPVAGTTAVAGQVPIMGAVKFGGDVCAAGSVSIAGKCACGCXEGYGYGLGSPYLY
What is the function of this protein?
This protein is one of many from the eggshell of the gypsy moth.
What are the official names of this protein?
Chorion class A protein Ld5.
What is the protein family that this protein belongs to?
Belongs to the chorion protein family.
Protein: KDPB_SALNS
Sequence: MSRKQLALFEPVLLVQALTDAVKKLSPRAQWRNPVMFVVWAGSVLTTLLTLAMVTGQIAGSALFTGIISLWLWFTVLFANFAEALAEGRSKAQANSLKGVKKTAFARRLRAPRHDAQADNVPAAELRKGDIVLVKAGDIIPCDGEVIEGGASVDESAITGESAPVIRESGGDFASVTGGTRILSDWLVIACSVNPGETFLDRMIAMVEGAQRRKTPNEIALTILLIALTIVFLLATATLWPFSAWGGNAVSVTVLVALLVCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGDVDVLLLDKTGTITLGNRQASDFIPARGVDERTLADAAQLASLADETPEGRSIVILAKQRFNLRERDVQSLHATFVPFTAQSRMSGINIDNRMIRKGSVDAIRRHVESNGGHFPADVEQNVENVARLGATPLVVVEGARILGVIALKDIVKGGIKERFAQLRKMGIKTVMITGDNRLTAAAIAAEAGVDDFLAEATPEAKLALIRQYQAEGRLVAMTGDGTNDAPALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLIEVVHIGKQMLMTRGSLTTFSIANDVAKYFAIIPAAFAATYPQLNALNVMGLHSPNSAILSAVIFNALIIIFLIPLALKGVSYKPLSASAMLRRNLWIYGLGGLVVPFIGIKVIDVLLTLLGLA
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SLIT2_RAT
Sequence: MSGIGWQTLSLSLALVLSILNKVAPHACPAQCSCSGSTVDCHGLALRIVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRILQLMENKISTIERGAFHDLKELERLRLNRNNLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPIACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPDHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRISCVGNDSFTGLGSVRLLSLYDNQITTVAPGAFGTLHSLSTLNLLANPFNCNCHLAWLGEWLRRKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPSECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVP
What is the function of this protein?
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors.  During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions.  SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.  In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin.  In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex.  May be implicated in spinal cord midline post-crossing axon repulsion.  In vitro, only commissural axons that crossed the midline responded to SLIT2.  In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm.  In vitro, collapses and repels retinal ganglion cell growth cones.  Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration.  Seems to be involved in regulating leukocyte migration (By similarity).
What are the official names of this protein?
Slit homolog 2 protein, Slit-2.
What are the subcellular locations of this protein?
Secreted.
Protein: HUTG_RALSO
Sequence: MHTEADPTVWQGRVDAEEGALGQRWHQVVRSADAASPLNGAVALAGFACDAGIARNHGRVGAQAGPAAIRRMLANLPARPGRAIVDAGDVTCRGDALEAAQDALSGVLHGLLDRGAFPIALGGGHELAWASFGGLARHLAARSAQPPRIGILNLDAHFDLRAGERGSSGTPFRQIAEDCARRGWPFRYACLGISAYANTEALFARARQLGVRWLRDDEMDLLHLPRVLQTVDAFLADVDHVYLTICLDVLPAGVAPGVSAPSARGVPMEVIEPIVDRVAASGKLRLADVAELNPSLDIDHRTARVAARLVARVVDGVAPQGAAHG
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: MICA2_RAT
Sequence: MGENEDEKQAQASQVFENFVQATTCKGTLQAFNILTCLLDLDPLDHRNFYTQLKSKVNTWKAKALWHKLDKRGSHKEYKRGKACSNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDTFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVRVREPPKDQENRKIGWRAEFLPADHALSNFEFDVIIGADGHRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDSTHYFVMTAKKQSLLDKGVILNDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAINHNGQPDVAMFDFTSMYASENAALMRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWDQGTPPLEVLAERESLYRLLPQTTPENINKNFEQYTLDPATRYPNLNVHCVRPHQVKHLYITKEMDRFPLERWGSVRRSASLSRRESDIRPNKLLTWCQQQTKGYQHVRVTDLTTSWRSGLALCAIIHSFRPELINFDSLNENDVVENNQLAFDVAKREFGILPVTTGKEMASTQEPDKLSMVMYLSKFYELFRGTPLRPMDSRRKNYGENADFGLGKTFFQNNYLNLTLPRKRTPRVDAQTEENDVNKRRRQGFNNLEELPAFSSRSLGSSQEYAKESGNQNKVKYMANQLLAKFEENTRNPSALKQDCPRVSGMGKPVLCSASRPPGTSHCPKLEESTPRLPPPLKRQFSSTVATGQVLRELNQVPASGECPGRPWRARAKSDLQLGGAENLATLPPTCQGALALSGVLRRLQQVEEKVLQKRAQNLANREFHTKNIKEKAAHLASMFGHGDLPQDKLLSKRVPHAHPPSPPSCLPSPDPAAAPSPPAADSVSPARKVLTVGKVSSGIGAAAEVLVNLYLNDHRPKTQATSPDLESLRKAEFPLSLGGRDTCYFCKKRVYVMERLSAEGHFFHRECFRCSVCAAILRVAAYAFDCDEGKFYCKLHFAHCKTSSKQRKRRAELNQQREEEGTWPEQEAARRDVPAESSCAVAAISTPEGSPPDEPISPKKSKSVPKPNSRPMEVEATSPRPSEWTSVRIGPGQDGQDVLAVRVLVTSEDSSSDTESDSGSIIGPCTEACEERPRLPESPPLSQPLTRHISLRETLTQPVSLLLHHKEPQAVPGLQRAYSLQSPSKYQNWRRKFQSNSTPMNQRALSPPKEPPPSSSSSSPSLPSSFSSASVPGHTTDDSSSPQVTYNLHSPQISRDDVSPTPIYLRRARAQGITKEIPLYLPHSPMLESTEHCLVSPDGEELRSPEEISASDGCQKALALGNSESTHKDSYPVSGKDPYLPNQMLALGAAGNTGDLSEESRMGQTGGAELSKERKLGLKKLVLTEEQKTMLLDWNDYTQEHKAGERLAQEKAENGRGNSLKPICSSTLSQAVKEKLLSQKKALGETRTPAAKAPREREVPPPKSPLRLIANAIFRSLLPSSEAGKKTSSKPETKTLPRGQPHAFTRSFSFRKLGSSKDGDQQSPGRHMAKKASAFFSLASPTSKAAQASDLSPPNPILRSRSLPNRPSKMFFATTSLPPSSKVEDVPTLLEKVSLQDAAQGPKKGASHISPLGLKDKSFESFLQECKERKDIGDFFNSPKEKGPPGNRVPSLEKLVQPVDSTSMGQVAHPSSTGQDAQAAVRTQAGKEGSSLVSSLVLVSGPGAPVTEDTSSPTSSSAEEDVETQLSSRLKEKIPRRRRKLEKQMAKQEELKRLHKAQAIQRQLEEVEERQRTSEIQGVRLEKVLRGETADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQELELEDHQSRLEQKLRQKMLKDEGQKDENDLKEEQEIFEEMMQVIEQRNKLVDSLEEQRIKERTQDQHFENFVLSRGCQLSRT
What is the function of this protein?
Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity).  Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network.  Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription.  Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity).
What are the official names of this protein?
[F-actin]-monooxygenase MICAL2, MICAL C-terminal-like protein, Mical-cL, Molecule interacting with CasL protein 2, MICAL-2, Protein RSB-11-77.
What is the protein family that this protein belongs to?
Belongs to the Mical family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RIMP_VIBPA
Sequence: MTGLERQLTEMLEAPVEASGYELVGLEFIRAGAHSTLRIYIDHENGINVDDCAEVSHQVSAVLDVEDPISVAYSLEVSSPGLERPLFKAAHYEQFIGHEVSIVLKMAVANRRKWKGIIHGVDGETVTVTVEGQQEEFALSNISKANLIPKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRE_HISS2
Sequence: MEHYISLFVKSVFIENMALSFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGISVPVNQLVYSLILKDGALIDGVDLSFLNFITFIGVIAALVQILEMILDKYFPALYNALGIFLPLITVNCAIFGGVSFMVQRDYNFAESIVYGIGAGTGWMLAIVALAGITEKMKYADVPAGLRGLGITFITVGLMALGFMSFSGVQL
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit E, Na(+)-NQR subunit E, Na(+)-translocating NQR subunit E, NQR complex subunit E, NQR-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EFTS_SULNB
Sequence: MANFGPKDIKKLREMTDAGMMDCKKALTEADGDMDKAVEWLRDQGMGAAAKKAGKVAAEGAIGIKVEGHKAVIVEINSQTDFVAQNDKFKALMDTVVNHAFENNLADAEAINNSTINGEPFADFLSQQIAIIGEKLVVRRAALIVGDETTAVNGYVHSNAQNGVIIEAKCDSAKTAEAMTPVLKEVAMHAAAMAPSTLSFKDFDPKFVEDETKGRIVAIETENEELRRLGKTEKNVPQYISMSQLTDEVMAAAEEALKAELAAEGKPEKIWDKILPGKLARFISDNTTLDQEQCLLDQKFVMDDSKTVFEYVQEKAKAAGGSAEIVHFVRLEVGEGIEVEEEDFAAEVAKQMA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_BORBR
Sequence: MSVAVLAFGLNHTSAPVSVRERVSMPVDLVKPALEGLRATFGGAVREAAILSTCNRTELYCAAEGQVAEHLPAWLAEHNRLEAAALRPHLYRHQHDDAVRHAFRVASGLDSMVLGEPQILGQMKDAVRAANEAGALGTLLHQLFQRTFSVAKEVRSQTAIGAHSVSMAAAAVRLAERVFGQLEDARTLFIGAGEMIELCATHFAAQRPRSMVVANRTIERAETLAGRFSAQTMKLADLTERLAEFDVIVSCTASSLPILGLGMVERATRQRRHRPMVMIDLAVPRDIEPEVGRLDDVYLYSVDDLGRLVQSGTDARRAAVVQAEAIIETRVQGFMHWMQSREVVPVIRDLHQAADDVRAAELERARRMLARGESPEAVLEQLAHGLTQKYLHGPLAALNRSEGDERRQLLAWVPRLFPGRDSRR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: SMRD2_RAT
Sequence: MSGRGAGGFPLPPLSPGGGAVAAALGAPPPPAGPGMLPNPALRGPGPSGGMGVPGAAAFRPMGPAGPAAQYQRPGMSPGSRMPMAGLQVGPPAGSPFGTAAPLRPGMPPTMMDPFRKRLLVPQAQPPMPAQRRGLKRRKMADKVLPQRIRELVPESQAYMDLLAFERKLDQTIARKRMEIQEAIKKPLTQKRKLRIYISNTFSPSKADGDNSGTAGTPGGTPAADKVASWELRVEGKLLDDPSKQKRKFSSFFKSLVIELDKELYGPDNHLVEWHRMPTTQETDGFQVKRPGDLNVKCTLLLMLDHQPPQYKLDPRLARLLGVHTQTRAAIMQALWLYIKHNQLQDGHEREYINCNRYFRQIFSCGRLRFSEIPMKLAGLLQHPDPIVINHVISVDPNDQKKTACYDIDVEVDDPLKAQMSNFLASTTNQQEIASLDVKIHETIESINQLKTQRDFMLSFSTEPQDFIQEWLRSQRRDLKIITDVIGNPEEERRAAFYHQPWAQEAVGRHIFAKVQQRRQELEQVLGIRLT
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).  Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.  Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2, 60 kDa BRG-1/Brm-associated factor subunit B, BRG1-associated factor 60B, BAF60B.
What is the protein family that this protein belongs to?
Belongs to the SMARCD family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1767_ALCBS
Sequence: MSEGVLKGKLFCSIYKSRRKSGMYLYVDRQKGLKEVPEILMGQFGHAEHVTDMILNPTRPLARADVEQVMEKIREQGFYLQMPPPPDEDLFMADGHPDKPVRHDA
What are the official names of this protein?
YcgL domain-containing protein ABO_1767.
Protein: AROC_ENTFA
Sequence: MRFITAGESHGPELTAIIEGLPAGLPLSSEEINRELARRQGGYGRGGRMKIEKDQVRITSGIRHGKTLGSPVTLIVENKDWKNWTSVMSVEPVPEKQKKIRRVSKPRPGHADLVGGMKYQHDDLRNVLERSSARETTMRVAIGAVAKKLLAELDIQVAGHVAVLGGIEATIPENLTIREIQERSEQSAVRVLDPSVEEKMKELIDQTKKNGDTIGGVVEVLVGGVPAGLGSYVQWDRKLDAKIAQAVVSINAFKGAEFGIGFEMAQRPGSQVMDEIVWDESTGYTRTSNNLGGFEGGMTNGMPIIVRGVMKPIPTLYKPLQSVNIDTKEPYKASVERSDSTAVPAASVVCEAVVATEVAKAMLEKFDSDSFEQMKEAVKRYRLYTQNF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: Y1486_BACVZ
Sequence: MENKRQGIIVYLHSLKHSKMLRKFGNVHYVSKRLKYVVLYCDMDLIEKTMEKISSYSYVKKVEPSYKPFLKLEFESKLDKAKEYDYKVGI
What are the official names of this protein?
UPF0298 protein RBAM_014860.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TEX43_BOVIN
Sequence: MASGKDTCPILPKLTNNCSDENSDKLANKCEIHLPRFSLKQGMIPRHYVMPWKQNMKFRNVNLKHAEACGIHAGPLEDSLFLDHSERLCHGEDRKVVLKKGPPEIKIADMPLHSPLSRYQSTVISHGFRRRLI
What are the official names of this protein?
Testis-expressed protein 43.
Protein: IHFA_ACIB5
Sequence: MTALTKADMADHLSELTSLNRREAKQMVELFFDEISQALIAGEQVKLSGFGNFELRDKRERPGRNPKTGEEIPISARRVVTFRAGQKFRQRVGNEQID
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: NORA_STAAN
Sequence: MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
What is the function of this protein?
Involved in quinolone resistance.  May constitute a membrane-associated active efflux pump of hydrophilic quinolones (By similarity).
What are the official names of this protein?
Quinolone resistance protein NorA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APOE_ONYTO
Sequence: MKALWAVLVVTLLAGCLAEGEPELEPEVTDRLAWQSGQPWELALGRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTELKAYKKELEEQLGPMAEETRARLAKEVQAAQSRLGADMEDLRNRLGQYRNEVQTMLGQSTEELRARLSTHLRKLRKRLMRDAEDLQKRLAVYKAGAREGAERGVGAIRERLGPLVEQGRQRTANLGAGAGKPLQDRAQALGARIRGRLEEVGNQARDRLEEVREQMEEVRAKVEEQAQQMRLQAEIFQARLKGWFEPLVEDMQRQWANLVEKIQASVAANPIPPSSVPQESQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: TUSA_SHEWM
Sequence: MSNQFSEAQHQLDALGLRCPEPVMMVRKSVRKMAQGETLLIIADDPATTRDIPSFCEFMDHKLLASQTETTPYQYLIQKGL
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.