PharMolix/UniProtQA huggingface dataset:
Protein: CRF_BOVIN
Sequence: MRLRLLVSVGVLLVALLPSPPCRALLSRGPIPGARQASQHPQPLSFFQPPPQPQEPQALPTLLRVGEEYFLRLGNLDETRAAPLSPAASPLASRSSSRLSPDKVAANFFRALLQPRRPFDSPAGPAERGTENALGSRQEAPAARKRRSQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIAGK
What is the function of this protein?
Hormone regulating the release of corticotropin from pituitary gland (By similarity).  Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
What are the official names of this protein?
Corticoliberin, Corticotropin-releasing factor, CRF, Corticotropin-releasing hormone.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPB_YERPG
Sequence: MTDSTIRIAIVGAGGRMGRQLIQAVTQMEGVVLGAAIERKGSTLVGSDAGELAGVGLLNVIVGDDLSQLTDNFDVLIDFTRPEGTLEHLAICRQHRKAMVIGTTGFDEAGKAAISEAAADIGIVFAANFSVGVNVVLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIADAMGRSLKDCAVYSREGYTGERKPGTIGFATVRAGDIVGEHTAMFADIGERVEITHKATSRMTFAHGAVKSAIWLGKHDNGLFDMRDVLNLNEL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAX81_ANDMA
Sequence: VSCEDCPEHCSTQKAQAKCDNDKCVCEPI
What is the function of this protein?
Blocker for the small conductance calcium-activated potassium channels (KCa2).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 8.1, AmP01, P01, PO1.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 08 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR7_ACIAD
Sequence: MLKQTLLYTGKAKSVYETDSADHLILVFRDDASAFNGEKIEQLDRKGKVNNRFNAFIMEKLAEAGIETHFEKLLTPNEVLVKKLNMIPVECVIRNYAAGSLCRRLGVEEGKQLTPPTFELFFKDDALGDPMVNESQAIALGWATADQLEKMKELTYQVNDVLKALFDAGNMILVDFKLEFGVFHDRIVLGDEFSPDGCRLWDKDTKKKLDKDRFRQGLGGVVEAYEEVAARLGINLDDI
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: GPMA_SALG2
Sequence: MAVTKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGFSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNDTILPRMKSGERVIIAAHGNSLRALVKYLDNMSEDEILELNIPTGVPLVYEFDENFKPLKHYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: CATL_DROME
Sequence: MNHLGVFETRFRPRTRHKSQRAQLIPEQITMRTAVLLPLLALLAVAQAVSFADVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV
What is the function of this protein?
Important for the overall degradation of proteins in lysosomes.  Essential for adult male and female fertility.  May play a role in digestion.
What are the official names of this protein?
Cathepsin L, Cysteine proteinase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: THOC2_HUMAN
Sequence: MAAAAVVVPAEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGNLKHEQASNVLSDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGSITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHKREIAEAKQIVRKLTMVVLSSEKMDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQHAQNIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVNALQNKRAPKQAESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKERMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKVQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR
What is the function of this protein?
Required for efficient export of polyadenylated RNA and spliced mRNA.  Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA.  TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.  The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.  THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains.  Required for NXF1 localization to the nuclear rim.  Plays a role for proper neuronal development.
What are the official names of this protein?
THO complex subunit 2, Tho2, hTREX120.
What is the protein family that this protein belongs to?
Belongs to the THOC2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: ALL19_CARMA
Sequence: APTDMYSFGL
What is the function of this protein?
May act as a neurotransmitter or neuromodulator.
What are the official names of this protein?
Carcinustatin-19.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSRP_CLOB6
Sequence: MSKKKGSNTLAENRKARHDYFIEETYEAGIELVGTEVKSIRQGKANLKDSYAEIRNGEVFVRNMHISPYEQGNIYNKDPLRDRKLLLHKSEIYKLVGFTTQQGYTLIPLSLYLKHGRVKVSLAVAKGKKNYDKRDAMLEKAAKREMDRQIKERSRY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RSRP1_HUMAN
Sequence: MSNYVNDMWPGSPQEKDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSRSRRSKSRSRSRRRHQRKYRRYSRSYSRSRSRSRSRRYRERRYGFTRRYYRSPSRYRSRSRSRSRSRGRSYCGRAYAIARGQRYYGFGRTVYPEEHSRWRDRSRTRSRSRTPFRLSEKDRMELLEIAKTNAAKALGTTNIDLPASLRTVPSAKETSRGIGVSSNGAKPELSEKVTEDGTRNPNEKPTQQRSIAFSSNNSVAKPIQKSAKAATEEASSRSPKIDQKKSPYGLWIPI
What is the function of this protein?
Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.
What are the official names of this protein?
Arginine/serine-rich protein 1.
What is the protein family that this protein belongs to?
Belongs to the RSRP family.
Protein: PP102_ARATH
Sequence: MRISISSVVSSTTSRFVHRNLQGKGNPRIAPSSIDLCGMCYWGRAFSSGSGDYREILRNGLHSMKLDDAIGLFGGMVKSRPLPSIFEFNKLLSAIAKMKKFDLVISLGEKMQRLGISHNLYTYNILINCFCRRSQISLALALLGKMMKLGYEPSIVTLSSLLNGYCHGKRISDAVALVDQMVEMGYRPDTITFTTLIHGLFLHNKASEAVALVDRMVQRGCQPNLVTYGVVVNGLCKRGDIDLAFNLLNKMEAAKIEANVVIYSTVIDSLCKYRHEDDALNLFTEMENKGVRPNVITYSSLISCLCNYERWSDASRLLSDMIERKINPNVVTFNALIDAFVKEGKLVEAEKLYDEMIKRSIDPDIFTYSSLINGFCMHDRLDEAKHMFELMISKDCFPNVVTYNTLINGFCKAKRIDEGVELFREMSQRGLVGNTVTYTTLIHGFFQARDCDNAQMVFKQMVSDGVHPNIMTYNTLLDGLCKNGKLEKAMVVFEYLQRSKMEPTIYTYNIMIEGMCKAGKVEDGWDLFCSLSLKGVKPDVIIYNTMISGFCRKGLKEEADALFRKMREDGPLPDSGT
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g63400.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: VDAC3_RAT
Sequence: MCSTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLIFTQKWNTDNTLGTEISWENKLAEGLKLTVDTIFVPNTGKKSGKLKASYRRDCFSVGSKVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLCQNNFALGYKAEDFQLHTHVNDGTEFGGSIYQRVNEKIETSINLAWTAGSNNTRFGIAAKYRLDCRTSLSAKVNNASLIGLGYTQSLRPGVKLTLSALVDGKNFNAGGHKVGLGFELEA
What is the function of this protein?
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity).  Involved in male fertility and sperm mitochondrial sheath formation (By similarity).
What are the official names of this protein?
Voltage-dependent anion-selective channel protein 3, VDAC-3, rVDAC3, Outer mitochondrial membrane protein porin 3.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic mitochondrial porin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane. Membrane. Note=May localize to non-mitochondrial membranes.
Protein: RR11_EUGLO
Sequence: MAMVYIKMSFHNTIVTVIDGRANVLSWCSSGVCKFKGRQKTTAFATKIVITRALKSVLERGFNGIDIKVSGPGFGRNVAIRAIIKMGFKVFSLKDITPLPYNGCRPRKRRRT
What are the official names of this protein?
Plastid 30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid.
Protein: RS7_SHEFN
Sequence: MPRRRVVGQRKILPDPKFHSELLAKFINVIMQDGKKSTAEKIIYKALDVVAEKKSENHLSILEAALDNVRPSVEVKSRRVGGSTYQVPCEVRPVRRNALAMRWLVEAARKRGEKSMALRLAGEMLDASENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: BRK3_PITAZ
Sequence: VPPGFTPFRQS
What is the function of this protein?
May produce in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity).  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser, [Val1,Hyp2,Thr6]-bradykinin-Gln,Ser.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS7_MYCTO
Sequence: MTTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPEP1_ARTBC
Sequence: MAALFVSLLALTSLVPVQGAATVPQTDYAKRAERVLRSAPLIDGHNDLPYAIRRSTNDQIYDGKLPFETSLKGHTDLPRMRKGRMGGQFWSVFIACPSDPNAPINTPKFATRDTLEQIDVARRLVDKYSKDLMYCDNPGCAKRAFREGKIGSFIGIEGGHQVGSSIAALRQAFYAGARYMTLTHNCDNAWATAASTVRAGKPDLGMTDFGPALIKEMNRLGMLVDLSHVSHQTMRDVLKITKAPVIFSHSSAYEVSKHLRNVPDDVLKTVAKNNGVVMVTFVSSFVKVDDPDSADVNTVVKHIFHIAEVAGWDHVGLGGDYDGTTELPKGLEDVSKYPYLIEKVLEAGATEEQARKLVGENVLRVWTEVEQIAKKIQRSGVLPVEEVWKGRNGTALSERSTFIEGPAPLEYGCD
What is the function of this protein?
Hydrolyzes a wide range of dipeptides.
What are the official names of this protein?
Putative dipeptidase ARB_02715.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
Protein: NIP7_XENTR
Sequence: MRPLTDEETKAMFEKLSKYIGENIKLLVDRPDGTYCFRLHNDRVYYVSERILKLATNIARDKLVSLGTCFGKFTKTHKFRLHVTALDYLAPYAKYKVWVKPGAEQSFLYGNHVLKSGLGRITENTSQYQGVVVYSMADIPLGFGVAAKSTQECRKLDPMAIVVFHQADVGEYIRHEDTLT
What is the function of this protein?
Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
What are the official names of this protein?
60S ribosome subunit biogenesis protein NIP7 homolog.
What is the protein family that this protein belongs to?
Belongs to the NIP7 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GSH1B_ORYSJ
Sequence: MAVASRLAVARVAPDGGAAGRRRRRRGRPVVAVPTAAGRGRGRGGAVAASPPTEEAVQMTEPLTKEDLMAYLVSGCKPKENWRIGTEHEKFGFEVDTLRPIKYDQIRDILNGLAERFDWDKIVEENNVIGLKQGKQSISLEPGGQFELSGAPLETLHQTCAEVNSHLYQVKAVGEEMGIGFLGIGFQPKWALSDIPIMPKGRYEIMRNYMPKVGSLGLDMMFRTCTVQVNLDFSSEQDMIRKFRTGLALQPIATAIFANSPFKEGKPNGYLSLRSHIWTDTDNNRSGMLPFVFDDSFGFERYVDYALDVPMYFVYRNKKYIDCTGMSFRDFMVGKLPQAPGELPTLNDWENHLTTIFPEVRLKRYLEMRGADGGPWRRLCALPAFWVGLLYDEESLQSISDMTSDWTNEEREMLRRKVPVTGLKTPFRDGYVRDLAEEILQLSKNGLERRGYKEVGFLREVDAVISSGVTPAERLLNLYETKWQRSVDPVFQELLY
What are the official names of this protein?
Glutamate--cysteine ligase B, chloroplastic, Gamma-ECS B, GCS B, Gamma-glutamylcysteine synthetase B.
What is the protein family that this protein belongs to?
Belongs to the carboxylate-amine ligase family. Glutamate--cysteine ligase type 2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRUD_METM5
Sequence: MPININKFILDMERFDGTLKKYPEDFIVEEITPEGTVLEVGKEIGFEDVEKWHGSFIHFTVEKTNWNTMDALKQIVRTTKTKRKNFGFAGTKDKFAVTTQRFGCFGLKKEQLENINIKDIVIRDVQKSNKKLRMGDLWGNKFTIKIRGLDLSKKEIKRISDLKLDYVLNYYGIQRFGLIRPITHIVGKFIYERDFESAFYTYCGTPISETGDSLEARQLVDVGEFKKALKLFNRNHDYEKRLIQQYLKYKDFKMAFTALPPQLNSMFVNAYQAYLFNEMINKRFEYGFDAKEGDILEDNTPTGTLIGYNTEFSGGIQGEIEKEIVERENLDLKKFKIEDFGNFYGTRRKMITPIYDFKSSFENDIFELSFKLERGNYATIVTREFTGNLS
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: P2OX_PENSG
Sequence: MSTSSSDPFFNFAKSSFRSAAAQKASASSLPPLPGPDKKVPGMDIKYDVVIVGSGPIGCTYARELVGAGYKVAMFDIGEIDSGLKIGAHKKNTVEYQKNIDKFVNVIQGQLMSVSVPVNTLVVDTLSPTSWQASTFFVRNGSNPEQDPLRNLSGQAVTRVVGGMSTHWTCATPRFDREQRPLLVKDDADADDAEWDRLYTKAESYFQTGTDQFKESIRHNLVLNKLAEEYKGQRDFQQIPLAATRRSPTFVEWSSANTVFDLQNRPNTDAPEERFNLFPAVACERVVRNALNSEIESLHIHDLISGDRFEIKADVYVLTAGAVHNTQLLVNSGFGQLGRPNPTNPPELLPSLGSYITEQSLVFCQTVMSTELIDSVKSDMTIRGTPGELTYSVTYTPGASTNKHPDWWNEKVKNHMMQHQEDPLPIPFEDPEPQVTTLFQPSHPWHTQIHRDAFSYGAVQQSIDSRLIVDWRFFGRTEPKEENKLWFSDKITDAYNMPQPTFDFRFPAGRTSKEAEDMMTDMCVMSAKIGGFLPGSLPQFMEPGLVLHLGGTHRMGFDEKEDNCCVNTDSRVFGFKNLFLGGCGNIPTAYGANPTLTAMSLAIKSCEYIKQNFTPSPFTSEAQ
What is the function of this protein?
Catalyzes the oxidation of various aldopyranoses and disaccharides on carbon-2 to the corresponding 2-keto sugars concomitant with the reduction of O(2) to H(2)O(2).  Plays an important role in lignin degradation of wood rot fungi by supplying the essential cosubstrate H(2)O(2) for the ligninolytic peroxidases, lignin peroxidase and manganese-dependent peroxidase (By similarity).
What are the official names of this protein?
Pyranose 2-oxidase, P2Ox, POD, POx, PROD, Pyranose oxidase, FAD-oxidoreductase, Glucose 2-oxidase, Pyranose:oxygen 2-oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
What are the subcellular locations of this protein?
Periplasm. Note=Hyphal periplasmic space.
Protein: SST_XYLFA
Sequence: MTEFIPPGSLFHALSSPFPMKRGGQLHRARIAYETWGHLNASATNAILIMPGLSPNAHAAHHDSNAEPGWWESMLGPGKPIDTDRWFVICVNSLGSCKGSTGPASYNPITQAMYRLDFPALSIEDGANAAIEVVHALGIKQLASLIGNSMGGMTALAILLLHPDIARSHINISGSAQALPFSIAIRSLQREAIRLDPHWNQGHYDDTHYPESGLRIARKLGVITYRSALEWDGRFGRVRLDSDQTNDTPFGLEFQIENYLESHAHRFVHTFDPNCYLYLSRSMDWFDVAEYANGDILAGLARIRIQRALAIGSHTDILFPIQQQQQIAEGLRRGGTHATFLGLDSPQGHDAFLVDIAGFGPPVKEFLDEL
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine.
What are the official names of this protein?
Serine O-succinyltransferase, SST.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I50A0
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRLFKHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: RL11_COXB2
Sequence: MAKKITGYIRLQIKAGEANPSPPVGPALGQHGVNIREFCESFNTATKNIEKGLPTPVIITVYADRTFSFITKTPPASVLLKKFVLKGKSGSARPNTEKVGKATRQQLEEIAKMKTPDLTAADLEAAIRTIAGTARSMGIDVEGVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: MNTH_ESCF3
Sequence: MTNYRVESSSGRAARKMRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELIFSQPNLAQLGKGMVIPSLPTSEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGSRQQRYSATKWDVAIAMTIAGFVNLAMMATAAAAFHFSGHTGVADLDEAYLTLQPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFIRFHIPLWVRRTVTMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSDSKLMGDLVNSKRVKQTGWVIVVLVVALNIWLLVGTALGL
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CC130_DROME
Sequence: MGERKGQNKYYPPDYDPKKGGLNKFQGTHALRERARKIHLGIIIIRFEMPYNIWCDGCKNHIGMGVRYNAEKTKVGMYYTTPVFKFRMKCHLCDNHFEIQTDPGNLDYVILSGARRQENRWDPLQNEQVVPETKEVQKRLFDDAMYKLEHQAKDAKAGADARPVLQKLVERNMSVWDDSYMANSRLRAEFRQQKKEINGQQELDRQLLAKSSLDIALLPETTQDREMAALMKLQTKSALERESEQRLELLMRPALPGATVTTFGGLKRQKVLNTQLQVQDLGIRRKKLEETTSSATNEKPISLVGDYSSSDNDSNG
What are the official names of this protein?
Coiled-coil domain-containing protein 130 homolog.
What is the protein family that this protein belongs to?
Belongs to the CWC16 family.
Protein: MNMA_STAEQ
Sequence: MSNKDIRVVVGMSGGVDSSVTAYLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIAVCNQIGIPYYAVNFEEQYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLEHALKLGADYVATGHYARIRRHDDGHVEMLRGVDNNKDQTYFLNQLSQEQLSKVMFPIGDIEKSEVRRIAEEQNLATAKKKDSTGICFIGERNFKEFLSHYLPAQSGEMLTLNGKKMGQHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLNDNVLYVEQGFHHDALYSDYLIASDYSFVNPSEIDLEKGFECTAKFRYRQKDTKVYVQRENENSIRVTFAEPVRAITPGQAVVFYNQEVCLGGATIDDVYKNEGQLSYVV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPC1_MYCTO
Sequence: MFERFTDRARKVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVRSQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESGSPSTSLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDAAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASLRDREKTLVAQRAEREKQWRSGDLDVVAEVDDEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFSKGGGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFHQLTREEIIRMVDLMISRVAGQLKSKDMALVLTDAAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVVTVDVDNWDGEGPGEDAVFTFTGTRKPPAEPDLAKAGAHSAGGPEPAAR
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP (By similarity).
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpC1.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpC subfamily.