PharMolix/UniProtQA huggingface dataset:
Protein: LYRM1_DANRE
Sequence: MSRANVLSLYRRVLRIARSWKAQSSIPKDTDTEKKYITQEARTLFRQNQQITDPESIQRCMEECEARIEIGLHYRNPYPRPTYLPPMGLATQKGRKLRAQQRLRKQAKPVYLQSQDET
What are the official names of this protein?
LYR motif containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
Protein: CALH_PENDC
Sequence: MATEKTPDWKIVDLQWAPDLGPVPVQDAMRPTRESQGEQEMIARMWVMCAIQMQDKLCAAKCTKQHFERYRSWLTAEYERFKQPGYPQVPDSRELVDMSNDARLAAMNKLREGVKNTYMWPVIEGPWRVYDNVVDIVEGRVKLVKVLLQDGLLEKFYDWANGLSEVRPLFNRMGRSNSSLRILEIGAGTGGTTARALEGLKSDDGELLYSSYEFTDISPLFFDAARRRFEGYSNIEYRALDISRNAVEQGFEAGAYDLVIASNVLHATPCLVDTLKNVRLLLKPNGFLFNQELSPPGKYVDFMVGLLPGWWLGDADGRAEGPCIPPEEWHRRLEQAGFEGLHAVGFDSDPPYYYNANMIARPAVNA
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of calbistrin A and related compounds.  Calbistrin A is a secondary metabolite with an interesting structure that was recently found to have bioactivity against leukemia cells.  It consists of two polyketides linked by an ester bond: a bicyclic decalin containing polyketide and a linear 12 carbon dioic acid structure (PubMed:30598828).  The polyketide synthase calA is probably responsible for forming the decalin moiety.  Because calA lacks a designated enoylreductase (ER) domain, the required activity is provided by the trans-enoyl reductase calK (PubMed:30598828).  Following release from the PKS, calF then probably catalyzes the oxidation and the subsequent Diels Alder cycloisomerization that lead to the formation of the decalin moiety (Probable).  The decalin polyketide backbone includes two C-methyl groups, at C7 and C11 in backbone, of which the C7 position is probably methylated by the methyltransferase domain of calA.  A candidate for adding the methyl group at C11, if not done by CalA, is the cluster methyltransferase calH (Probable).  Several additional tailoring enzymes within the cluster could be involved in the modification of the decalin polyketide product.  Those include the 3 cytochrome P450 monooxygenases CalE, CalG and CalL, of which one might be responsible for the introduction of the extra hydroxyl group attached to the backbone of the decalin moiety, at position C9 in the backbone, that allows for attachment of the linear moiety (Probable).  One tailoring enzyme activity that is expected to be involved in biosynthesis of calbistrin is an acyltransferase for connecting the two polyketide synthase products, and which could be performed by the cluster acyltransferase calJ (Probable).  The enzyme responsible for the biosynthesis of the linear moiety, probably a second PKS, has not been identified yet (Probable).
What are the official names of this protein?
Methyltransferase calH, Calbistrin biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily.
Protein: STK4_DICDI
Sequence: MSTLNVPKETMSRKDPEKFFTIVEKLGEGSYGSVYKAINISTGIVVAIKKVSVDNDLEDMEKEISFMKQCKSPYIVTYYASFRKENEVWIVMEHCGAGSVCDAMKITDKTLSEDQIAVVSRDVLQGLAYLHSVRKIHRDIKAGNILMNHKGESKLADFGVSGQLSDTMAKRQTVIGTPFWMAPEVIQEIGYDYKADIWSYGITCIEMAESKPPLFNVHPMRVIFMIPNPSRPPPKLTEPEKWSPEFNDFLAKCLTRKPELRPSAEELLKHPFITKAKSHSLLVPLIDEQDIIINEKGREVALGIEQRDEEEEDEDEDSEDSDDNRGTMVRAKPRSMQNSGGEDNDEEYDTGTMVITDNKNSYDTVVFNNDDEDSGTMKLKNTMPSNKKNFVPDYMNQFKKSDDDVTNVPLSDKYSSYSLEELKKMLAELEIEREKEVQKTLEKFSINRQALLAVIDEKKSK
What is the function of this protein?
Regulates both cAMP signaling during early development and the stress response.  Functions as an activator of adenylylcyclase.
What are the official names of this protein?
Serine/threonine-protein kinase 4 homolog A, Kinase responsive to stress A, STE20-like kinase krsA.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ATP9_CHOCR
Sequence: MNVTLQSAKMIGAGLATIGLTGVGAGVGIVFGSLVMAYARNPSLKQQLFGYTILGFALTEAVALFALMMAFLILFT
What is the function of this protein?
This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.
What are the official names of this protein?
ATP synthase subunit 9, mitochondrial, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: REDX1_CATRO
Sequence: MADRVKTVGWAAHDSSGFLSPFQFTRRATGEEDVRLKVLYCGVCHSDLHNIKNEMGFTSYPCVPGHEVVGEVTEVGNKVKKFIIGDKVGVGLFVDSCGECEQCVNDVETYCPKLKMAYLSIDDDGTVIQGGYSKEMVIKERYVFRWPENLPLPAGTPLLGAGSTVYSPMKYYGLDKSGQHLGVVGLGGLGHLAVKFAKAFGLKVTVISTSPSKKDEAINHLGADAFLVSTDQEQTQKAMSTMDGIIDTVSAPHALMPLFSLLKPNGKLIVVGAPNKPVELDILFLVMGRKMLGTSAVGGVKETQEMIDFAAKHGIVADVEVVEMENVNNAMERLAKGDVRYRFVLDIGNATVAV
What is the function of this protein?
Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e. g.  tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine.  Catalyzes the first oxidation step of the unstable intermediate product resulting from the reaction triggered by the geissoschizine oxidase (GO) in the stemmadenine biosynthesis process from 19E-geissoschizine.
What are the official names of this protein?
Protein REDOX 1, Cinnamyl alcohol dehydrogenase 4.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: CARA_ACIAD
Sequence: MSTPAILALADGTIFKGTSIGATGSTTGEVVFNTAMTGYQEILTDPSYAQQLVTLTYPHIGNTGCNEEDTESGRIHKVWANGLIIRDLPLLHSNFRSEQSLAEYLIQHNVVAIADIDTRKLTRILRDKGAQNGCILAGENITEEEALAKARAFGGLNGLDLAKECCDPNGFEWTEGSWELGKGFTQPELKYHVVAYDYGVKTNILRMLADRGCKLTVVPAQTPAEQVLALNPDGVFLSNGPGDPAACDYAIEAVKTIVETTNLPVFGICLGHQILALASGAKTMKMNHGHHGANHPVQNLEQGTVMITSQNHGFAVDESTLPANLKVTHRSLFDGTNQGIHRTDKPAFSFQGHPEASPGPHDCAPLFDHFIELIEAAKK
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: DNAJ_BURM7
Sequence: MAKRDYYEVLGVAKNASDDEIKKAYRKLAMKYHPDRNPDSKDAEEHFKEAKEAYEMLSDGQKRAAYDQYGHAGVDPNVGAAGAQGFGGFADAFGDIFGDIFGQAAGGGRARGGPQVYRGADLRYSMEITLEQAAHGYDTQIRVPSWAACGVCHGSGAKPGTKPETCPTCHGQGTVRMSQGFFSIQQTCPKCHGTGTYIPEPCAHCHGSGKVKETKTLEVKIPAGIDDGMRIRSAGNGEPGINGGPSGDLYVEIHIKPHAVFERDGDDLHCQMPIPFTTAALGGEIEVPTLAGRASFTVPEGTQSGKTFRLRGKGIKGLHSSIAGDLYVHVQVETPVKLTDQQRDLLKQFEKSLAEGGPRHSPQSKSWFDRVKSFFE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T5G1B_AGEOR
Sequence: MKAIIFFCFLSVMVFIVAEASSLEALKIFEGERECVGENGHCRSWYNDCCDGYYCSCMQPPNCICRNNNG
What is the function of this protein?
Insecticidal neurotoxin that modulates the insect Nav channel (DmNaV1/tipE (para/tipE)) in a unique manner, with both the activation and inactivation processes being affected.  The voltage dependence of activation is shifted toward more hyperpolarized potentials (analogous to site 4 toxins) and a non-inactivating persistent sodium current is induced (site 3-like action).  Interestingly, both effects take place in a voltage-dependent manner, producing a bell-shaped curve between -80 and 0 mV.
What are the official names of this protein?
Mu-agatoxin-Ao1b, Mu-AGTX-Ao1b, Beta/delta-agatoxin-6, Mu-2Aaga_14.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 07 (Beta/delta-agtx) family. 04 (aga-5) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CDN11_RANGI
Sequence: GLLDGLLGTLGL
What is the function of this protein?
Caeridins show neither neuropeptide activity nor antibiotic activity.
What are the official names of this protein?
Caeridin-1.1/1.2/1.3.
What are the subcellular locations of this protein?
Secreted.
Protein: DHI1_BOVIN
Sequence: MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHIHYTPLGVFSNDIHLLRRTLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSIAGKIACPLVAAYSASKFALDGFFSSLRMEYEATKVNVSITLCILGLIDTDTAMKAVAGIFNAKASPKEECALEIIKGGTLRQDEVYYDSSILTPLLLRNPGRKIMEFFFLKKYNMERFINN
What is the function of this protein?
Controls the reversible conversion of biologically active glucocorticoids such as cortisone to cortisol, and 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) (PubMed:17470521).  Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (By similarity).  Plays a role in the secretion of aqueous humor in the eye, maintaining a normotensive, intraocular environment (By similarity).  Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (By similarity).  It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates.  Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity).  Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (By similarity).  7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity).  Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity).  Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity).
What are the official names of this protein?
11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11-beta-HSD1, 11HSD1, 7-oxosteroid reductase, Corticosteroid 11-beta-dehydrogenase isozyme 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: Y1289_HALVD
Sequence: MSDIQTSTVSEDGFACTSQVGDFDLQIDATDETGPNPNAALVATYASCFLPAFRVGGQKTGFDDLGKVQIDADADLDDSDDLERISFDVYVESDLSDDEFAEITELAEDICHVHDALRDELQADVTVVGDAF
What are the official names of this protein?
Uncharacterized protein HVO_1289.
What is the protein family that this protein belongs to?
Belongs to the OsmC/Ohr family.
Protein: YR331_MIMIV
Sequence: MPIIAVISKNNCQFDDLENYVLPLLYQYHDETTRLQLKNKLNDYLWEIIEPYVTFINCQSDIFMETICTHLVKEFPDKKLDDFFYHTESSFSFPKKHTELMYCQPTWSYQKDQEVNMNFIGCLFSLKHNVIENTCIVIANNYDISTQNNIVIGDVTKNDILRMVRRRYFFSAELIKNDTITKYYYQNPGYLVSKVFDLKEQDTIEKLTVGFLKYNLSFYCNQNKNQYVNKIATRINGLYQLYGDVLVLNEMDEHVYTNLSTHELRRLNVLAYGRLYDRQLKADEIHEESHVEVDEQGKEIEKKKTPLWSKYIIIDKRMSEWQNNKNKCFYCNKNIEKPVVCNKCFRIKYCSEKCQSEYNSYHSDDCINPKSITN
What are the official names of this protein?
Putative zinc finger MYND domain-containing protein R331.
Protein: YPTO_SHEVI
Sequence: MKLVMVSGRSGSGKSVVLRVLEDLGYYCVDNLPLPLMDTLLEQLKGSTDLVAISVDVRNMPEQDKEFLKQLANLPKGTELLSFFLDSSDEVLLKRYSETRRLHPLSRTKTSLKEAIEHERELLEPVSKMVDHYIDTSNLNIYDLSDKIREILLGSVDKELVINFESFGFKYGMPVEADFMFDVRFLPNPHWEPELRPMTGLDEPVQLFLSQQPTVNKFIWQIENLLATWLPHLERNNRSYLTIAIGCTGGQHRSVYVTEQLAKLFANSKHKIQARHRELSDD
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein in ptsN-ptsO intergenic region.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: RS18_STRTD
Sequence: MAQQRRGGFKRRKKFDYIAANKIEYVDYKDTELLSRFVSERGKILPRRVTGTSAKNQRKVTTAIKRARVMALMPYVNED
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: NUOB_BORBR
Sequence: MAIDGILKQGFITTSADKFLNWAKTGSMWPMTFGLACCAVEMMHAGAARYDLDQFGIIFRPSPRQSDLMIVAGTLCNKMGPALRKVYDQMPEPRWVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALVYGLLQMQNKIRLTNTIAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: APR_RAT
Sequence: MPGRKARRNAPLNPTRAELPPEFAAQLRKIGDKVYCTWSAPDITAVLAQMPGKKSRKSTMRRSPSPTRVPADLKDECDQLRRIGDKVNLRQKLLNFISKLFNLIT
What is the function of this protein?
Promotes activation of caspases and apoptosis.  Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria.  Contributes to p53/TP53-dependent apoptosis after radiation exposure.  Promotes proteasomal degradation of MCL1.  Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity).
What are the official names of this protein?
Phorbol-12-myristate-13-acetate-induced protein 1, Protein Noxa.
What is the protein family that this protein belongs to?
Belongs to the PMAIP1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MATK_PHYEM
Sequence: MAEFKRYLELDISQQHDFIYPLIFQEYIYALAHDRGLNRSIFLENAGYDNKSSLLIVKRLITHLITQMYQQNHFFFSVSDSNQKKNLGYNTNFYSQMIFEGFAVVMEIPFYLRLLSFLEGKERVKSHNLRSIHSIFPFLEDKFTYQNYVLDIQIPHPIHPEILVQTLRYWVKDASSLHLLRFFLHEYPIWNSLITQKKSIFYFSKKNQRFFLFLYNFHVCEYESIFVFLRNQSSYLRSISSETFLERISFYRKIEREVFTKDFKAILWLFKEPFLHYVRYRGKAILASKGTSLLMNKWKYYLLNFWQSYFYMWSQPRRIHINQLSNHSLDFLGYLSSVRLKPLMLRSQMIENSFLIENASKKFDTLMPITTMILSLYKAKFCNVVGHPMSKPAWAALSDSDIIERFRALYRNLSHYYSGSLKKISLYRIKYILRLSCARTLARKHKSTVRAFLKRLGVGLLEEFFTEEEQVFYLTFQKVSFTSGELYRRRIWYLDIICINDLANYE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NANE_YERPS
Sequence: MSNLSNLRHKLQNGLIASCQPVPGSAMDTPEIVAAMACAALAGGAVGLRIEGISNIQAVRRATDAPIIGIIKRDLPDSEVRITPWLEDIDALSAAGADIIAFDVTCRERPVSVADLYQRARATGCLTMADASNIDDGLLAHHLGIDFIGTTLSGYTQAIVPTEPDLALVTQLAQAGCRVIAEGRYHSPALAAAAISAGAYAVTVGSAITRIEHICGWFCDAIKQCETEKLTEY
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: LITAD_HUMAN
Sequence: MPVQAVCPYCGNRIITVTTFVPGALTWLLCTTLFLFGYVLGCCFLAFCIRSLMDVKHSCPVCQRELFYYHRL
What are the official names of this protein?
LITAF domain-containing protein, LITAF-like protein.
What is the protein family that this protein belongs to?
Belongs to the CDIP1/LITAF family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: CSPJ_SALTS
Sequence: MTTKITGLVKWFNPEKGFGFITPKDGSKDVFVHFSAIQSNEFRTLNENQEVEFSVEQGPKGPSAVNVVAL
What are the official names of this protein?
Cold shock-like protein CspJ.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPF_ECOLI
Sequence: MQLNITGNNVEITEALREFVTAKFAKLEQYFDRINQVYVVLKVEKVTHTSDATLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTKHKDKLKQH
What is the function of this protein?
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes (PubMed:18174192).  Converts immature 90S particles formed by RMF into 100S ribosomes (PubMed:16324148).  Crystallization with T. thermophilus 70S ribosomes shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation factors IF1 and IF3 and elongation factor G would bind; however RMF is still able to bind (PubMed:22605777).  In this crystal binding of HPF induces movement of the 30S head domain away from the rest of the ribosome, presumably so they would more easily form dimers (PubMed:22605777).  May also function as a potential translational inhibitor (PubMed:18174192).
What are the official names of this protein?
Ribosome hibernation promoting factor, HPF, Hibernation factor HPF.
What is the protein family that this protein belongs to?
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Protein: LEUC_CERS1
Sequence: MTAPRTLYDKIWDDHVVHQSEDGTCLLYIDRHLVHEVTSPQAFEGLRMTGRKVRAPEKTIAVPDHNVPTTEGRDTKIDNEESRIQVEALDRNARDFGINYYPVSDIRQGIVHIVGPEQGWTLPGMTVVCGDSHTATHGAFGALAHGIGTSEVEHVLATQTLIQKKSKNMKVEITGSLRPGVTAKDITLSVIGLTGTAGGTGYVIEYCGQAIRELSMEGRMTVCNMAIEGGARAGLIAPDEKTFAYVMGRPHAPKGAAWEAALAYWKTLFTDKGAQFDKVVTIRGEDIAPVVTWGTSPEDVLPITATVPAPEDFTGGKVEAARRSLEYMGLTPGQKLTDIKIDTVFIGSCTNGRIEDLRAAAEILKGKKVAPGMRAMVVPGSGLVRAQAEEEGLAQIFIDAGFEWRLAGCSMCLAMNPDQLSPGERCASTSNRNFEGRQGRNGRTHLVSPGMAAAAAITGHLTDVRDLMMAPAEPA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: Y1397_ARATH
Sequence: MTTEEESLSAAEEGYNVQRDYWRQAEESDGFDIENIKLPPGMHGRVMGLITYNCQLCYRYPFPVLVKLYAKFGLHRYNLIKGTSFELAALMKFNMLQNYMSSFYMTLLAHDPDPAASSSQKTFQVRVDEQQFGTLGINCSIARPKHEGDLLEVSTKTPFIPHFHGGALGDGIFKGELPDCLSDDALNALMEAVSKDELPEHVLDDALYARAGGIFQGELPDWPSDDALNDGKRFYMLKESEWQATDWISMYLELVITTTDRSITETVQKPEVLSKLEIVKVAIETATKDEEPSNERLKAYRAHFYITFKGLAEPRAPRQVFEIGEHVERQAIVRRVMGHRGDLTLKGKLCGGQYIKRRSLALKSGEESPNCKKQTRVG
What are the official names of this protein?
UPF0725 protein At1g23970.
What is the protein family that this protein belongs to?
Belongs to the UPF0725 (EMB2204) family.
Protein: IF2A_CHICK
Sequence: MPALSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPAILDSLDLTEEERRVLIDNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKTED
What is the function of this protein?
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.  This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex.  Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex.  In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.  EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1.
What are the official names of this protein?
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-alpha family.
What are the subcellular locations of this protein?
Cytoplasm, Stress granule.
Protein: AIP_MOUSE
Sequence: MADLIARLREDGIQKRVIQEGRGELPDFQDGTKATFHFRTLHSDNEGSVIDDSRTRGKPMELIVGKKFKLPVWETIVCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAEGKDPLEGQRHCCGIAQMHEHSSLGHADLDALQQNPQPLIFHIEMLKVESPGTYQQDPWAMTDEEKAKAVPVIHQEGNRLYREGQVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDLQITPLLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALETRIRQKDEEDKARFRGIFSH
What is the function of this protein?
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
What are the official names of this protein?
AH receptor-interacting protein, AIP, Aryl-hydrocarbon receptor-interacting protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHYS_DIACA
Sequence: MEDANHDSVASAHSAAFKKSENLEGKSVKIEGYDFNQGVNYSKLLQSFASNGFQASNLGDAIEVVNHMLDWSLADEAPVDDCSEEERDPKFRESVKCKVFLGFTSNLISSGVRDTIRYLVQHHMVDVIVTTTGGIEEDLIKGRSIKCLAPTFKGDFALPGAQLRSKGLNRIGNLLVPNDNYCKFEDWIIPILDKMLEEQISEKILWTPSKLIGRLGREINDESSYLYWAFKNNIPVFCPGLTDGSLGDMLYFHSFRNPGLIVDVVQDIRAVNGEAVHAAPRKTGMIILGGGLPKHHICNANMMRNGADYAVFINTAEEFDGSDSGARPDEAISWGKISGSAKTVKVHCDATIAFPLLVAETFAAKREKERKSC
What is the function of this protein?
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.  Also able to produce homospermidine from putrescine (By similarity).
What are the official names of this protein?
Deoxyhypusine synthase.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: RL24_KLEP3
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQISNLAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.