PharMolix/UniProtQA huggingface dataset:
Protein: NDHH_NASOF
Sequence: MKRPVTGKDLMIVNMGPHHPSMHGVLRLIVTLDGEDVVDCEPILGYLHRGMEKIAENRAIIQYLPYVTRWDYLATMFTEAITVNGPEQLGNIQVPKRASYIRVIMLELSRIASHLLWLGPFMADIGAQTPFFYIFREREFVYDLFEAATGMRMMHNFFRIGGIAADLPYGWIDKCLDFCDYFLTEVVEYQKLITRNPIFLERVEGVGIIGGEEAINWGLSGPMLRASGIPWDLRKVDRYESYDEFEWEIQWQKQGDSLARYLVRLSEMTESIKIIQQALEGLPGGPYENLESRGFDRKRNPEWNDFEYRFISKKPSPTFELSKQELYVRVEAPKGELGIFLIGDQSGFPWRWKIRPPGFINLQILPELVKRMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: SIF2_SCHPO
Sequence: MSNRIGPQRSTKTAAKLRLLPSTEEFDDFRRQDTGREVYSQIPQIEGSTAKRDAEHLGKRHREFLPRVTAYCTCDTFRVDLLFKFFQSRRSSHKTRPKQFDECIYSPYSYNNEETTDLLPDTLESSRGTLNRESSQESLQSIFEESGLDRNQPLFREVFCFTYGVVVLWGYTIDEEHRFLRELGRFEIEKLKIEDMEVEEFNYYITTLYQPRIFNDFIALRDASNYMIRLSISHAIAQSVKISLFEELVNETIDATKDTPQMIAETGRVNLKREEIMMAVGQLFILRININLQGSVLDSPELMWTEPQLEPIYTAARSYLEINQRVALLNQRVEVIGDLLSMLKEQITHTHDESLEWIVVILMGLLVLIALFSIVVDWKLFQ
What is the function of this protein?
Required for sporulation where it is believed to have a role in meiotic nuclear division.
What are the official names of this protein?
Sad1-interacting factor 2, Sporulation protein sif2.
What is the protein family that this protein belongs to?
Belongs to the RMD1/sif2 family.
What are the subcellular locations of this protein?
Nucleus membrane; Single-pass membrane protein. Note=Localized primarily along the nuclear envelope in a punctate pattern.
Protein: BUD31_CAEEL
Sequence: MSLATKLRRVRKSPPEGWDLIEPTLEQFEAKMREAETEPHEGKRKTEINWPIFRIHHQRSRYVYDMYYKKAEISRELYEFCLTAKFADAALIAKWKKQGYENLCCVKCVNTRDSNFGTACICRVPKSKLDAERVIECVHCGCHGCSG
What is the function of this protein?
Involved in pre-mRNA splicing process.
What are the official names of this protein?
Protein BUD31 homolog, Protein G10 homolog.
What is the protein family that this protein belongs to?
Belongs to the BUD31 (G10) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YSYF_CAEEL
Sequence: MYTCGNRKVIPNMPDLILRKIFDQYDYPVLCKMERVCRRWTNIINSKFRKEIHEISIERLGSMFPQAHQCVPFRRLSISCPSDSHDFLAGVFRRSRLSFMKMTTDINFLAGIDQIHVSKDNGRRYFSNVEDLWLLMIHPDDDVTQRFLAIEGTLFSELQQLTLQVHVNPRYYKNVGEIVKSFILRYPKSNINLELHAEKSMHILNQISNLPSLPLYKIKLICTDFDQPQLRLDQLYAVMREQNIQAKNITMRDWSLFADGTTPVSYNPLDTFRISSCSIETVDNLVKSIQMTASQGTHVDGVPPTKKKKVIRKKKETEVVTEEGVLPKPKKKVVKKVVKKKKPIAFIKKLEVAGQCTLHGLTFLQQKAHTELERRLTTLVPGLDVDCSEIYYCW
What are the official names of this protein?
Uncharacterized F-box protein ZK328.6.
Protein: GATC_PARDP
Sequence: MAITEDEARKVAHLARIAVKDADLPALAQELNGILHFMEQLNEVDVEGVQPMTGVEPMRLKRRQDIVTDGEMQDLILKNAPDAREGFFAVPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: RL22_MYCVP
Sequence: MTTAIEYPSAMAKARFVRISATKARRVIDLVRGKSVEEALDILRWAPQSASEPVAKVIASAAANAQNNEGLDPTSLVVATIHADEGPTAKRIRPRAQGRAYRIRKRTSHITVIVESRPPKKAGKQGASASAARARRAQASKAATKKATDSKEGSE
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL11_STACT
Sequence: MAKKVEKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTQEQAGLIIPVEISVYEDRSFTFITKTPPAPVLLKKAAGVEKGSGEPNKNKVATVTKDQVREIAQTKMPDLNAADEEAAMRIIEGTARSMGITVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ZAPB_ACTSZ
Sequence: MSSEILDQLESKIRQAVETIQLLQLEVEELKEKNDQAQQANDALRNENEQLKVEHNNWQERLRSLLGQIDNV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: TRPA_COXBN
Sequence: MNRIEQQFKKSPAYVAYLTAGDGGLERSLESLLALAKGGVNILEVGVPFSDPVADGPVIQEASIRALAQGTTLHDVLTLITSFRQHSEIPIILFTYFNPLLAAGDKIYQQMKSAGVDGCLVVDLPVEEAAPHLTACKTAKIAPILLISPSTTQERLKKINEHGEGMLYYVCRPGTTGVRATLPENFPAKMNQIKSMTSLPIVTGFGIANRKMAAQALQYADGFVIGSLFVKAIAEGISKNALTRLAQSLNPHYPNLRLITPFRKKTF
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: TGT_STRA3
Sequence: MTDHPIKYRLIKQEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKEMGSGIILSNTYHLWLRPGDELIAKAGGLHKFMNWDQAILTDSGGFQVYSLADSRNITEEGVTFKNHLNGAKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLNAHRRPHDQGLFGIVQGAGFEDLRRQSARDLVSMDFPGYSIGGLAVGETHDEMNAVLDFTVPMLPNDKPRYLMGVGAPDSLIDAVIRGVDMFDCVLPTRIARNGTCMTSQGRLVVKNAKFAEDFTPLDPNCDCYTCKNYTRAYIRHLLKADETFGIRLTSYHNLYFLVNLMKDVRQAIMDDNLLEFRQDFMERYGYGMNNRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: TGT_SHEAM
Sequence: MKFELITTQGRARRGRLVFERGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFMDAEKSMQIQHSLGSDVVMIFDECTPYPATHDEARKSMQMSLRWAKRSRDEFDRLENPNSLFGIIQGSVYEDLRDESLKGLLEIGFDGYAVGGLAVGEPKEDMHRVLEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFTSEGVIKIRNARHRDDTSPLDPKCDCYTCTNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMEGLRGAIETGTLDAFVADFYTSQGREVPELKD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: CYB_APOMU
Sequence: MTNIRKTHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLMIQIITGLFLAMHYTSDTTTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFIHIGRGMYYGSYTFMETWNIGVILLFAIMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALVIVHLLFLHETGSNNPTGLNSNADKIPFHPYYTIKDLLGVFMLILFLMTLVLFFPDMLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILAFLPFLHTSKQRSLMFRPITQVLYWMLVANLLILTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKLLKWSL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EX7L_STRP3
Sequence: MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFPGVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTLADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMASQYDSQLARFEKAQDALLSLDASRIIARGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSL4_ARCFU
Sequence: MRFVMPGDRIGSAEEYVKGEGVYEEGGELFAAVAGKLIIKDRVAKVESISPIPEIVKGDVVLGRVVDLRNSIALIEVSSKKGENRGPSNRGIGILHVSNVDEGYVKEISEAVGYLDILKARVIGDNLRLSTKEEEMGVLRALCSNCKTEMVREGDILKCPECGRVEKRKISTDYGKGEW
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Increases the RNA binding and the efficiency of RNA degradation.  Helpful for the interaction of the exosome with A-poor RNAs (Probable).
What are the official names of this protein?
Exosome complex component Csl4.
What is the protein family that this protein belongs to?
Belongs to the CSL4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP54_BPSP1
Sequence: MVIIKYTTKTQPTPVKEMFISPQHYAKWRSHMGSKLTSVKPIKGGR
What are the official names of this protein?
Putative gene 54 protein.
Protein: U4_TIBVC
Sequence: MITRKHIIKEIHLTTIMMICMRQLRMEELFTRHSMFSSIFNYSKTLDGLFSIHSP
What are the official names of this protein?
Uncharacterized protein U4.
Protein: HISX_SULAC
Sequence: MIKYEIPKSRPNEFSKVLPLVEQILNQVKERGDKALLELEEKYDKAKLDSLVENRIDELASKIPEEYKAAIDRIYDQLVEFHKTTLPYMVGGGYNGIEFGILWRAIEKVGIYVPGGLKSYPSTLLMAAIPARVAGVSEIYVATPPNRIDSVIAYIAKKLKINALYRIGGAQAIAALAYGTESVKKVDKIVGPGNIFVQASKFLVSKDVAIDGIEGPTELVVIADSSADYRHVILDMRAQAEHGSTSYIILVTTSDFLIDKVREELDKEEFTYYIVKVKSIDEAIDVANDIAPEHLSLFVNDPKSYLHKIKNAGAISLGKTPPALIDYAAGPDHILPTNAWSRVRGGLTVYDFLKPISYANSVNPDKELVNMAKLIAEYEGFIYHSKSIGARYE
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: DAPF_METTH
Sequence: MILFSKMHGLGNDYVVIDESAQECIPEDKKPEFVREVCTRGFSVGADGVIFVQPASGEGDIRFRIFNADGSEAEMCGNGIRCFSKFVYDNAIVRKRRLEVETLAGIKTVELEVEDGAVVSSRVDMGTATFKTDQIPMDVEEYEFIDRFLPVEGEDIKLTALSVGNPHAIIFVDDAEGVDLDRLGPAIENHPLFPERINVHFVEVVSPSEIIMVTWERGAGPTMACGTGATASVIAGVKLEKLDDSVLVHLPGGELKIDVYQDGTELGAYMEGDAVMVFDGILLRDP
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFP11_MACMU
Sequence: MSLSHLYRDGEGRIDDDDDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDDERPSFGGKRARDYSAPVNFISAGLKKGAAEEAELEDSDDEERPVKQDDFPKDFGPRKLKTGGNFKPSQKGFAGGTKSFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQSMQDFPVVDSEEEAEEEFQKELSQWRKDPSGSKKKPKYSYKTVEELKAKGRISKKLTAPQKELSQVKVIDMTGREQKVYYSYSQISHKHNVPDDGLPLQSQQLPQSGKEAKAPGFALPELEHNLQLLIDLTEQEIIQNDRQLQYERDMVVNLFHELEKMTEVLDHEERVISNLSKVLEMVEECERRMQPDCSNPLTLDECARIFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADAFHRLIWEVWMPFVRNIVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTVPIHSWIHPWLPLMQARLEPLYSPIRSKLSSALQKWHPSDSSAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQHMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKWYLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERRKDFQYEAMQERREAENMAQRGIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHEGKQLYTFGRIVIYIDRGVVFVQGEKTWVPTSLQSLIDMAK
What is the function of this protein?
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.  Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS).  In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.  May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
What are the official names of this protein?
Tuftelin-interacting protein 11, Septin and tuftelin-interacting protein 1, STIP-1.
What is the protein family that this protein belongs to?
Belongs to the TFP11/STIP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.
Protein: GPMA_BEII9
Sequence: MDRLLVLVRHGQSDWNLKNLFTGWKDPDLTEKGIGEAQAAGRGLKAKGLAFDIAFTSALTRAQHTLKLILGELGTPDVPTTREQALNERDYGDLSGLNKDDARQKWGEEQVHVWRRSYDISPPGGESLKDTVARVLPYYCQSILPAVLDGKKTIVAAHGNSLRALVMVLDGLTPETIPSMELETGVPLIYRLRANSTVESKEVLKLG
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: TRPD_SYNFM
Sequence: MIQDGIKKIIQREDLSETEMSAVMSEIMSGEATDAQIGAFMGALATKGETFEELAGAARTMRRKAARIQVTSPVIVDTCGTGGDRKGTFNISTTAAFVVAGCGVTVAKHGNRSVSSQCGSADLLEALGMRLDAPAEVVEEAIGRIGIGFLFAPLFHGAMRHAARARKEVGVRSIFNMLGPLTNPAGANCQVLGVYAPQLTEMFAQALRLLGARRAFVVHGQDGLDEISVCAPTRVSELDGGLVRTYDLQPELLLGRKADPEDLAGGDPGVNAKITRDVLGGAIGPRRDVVVLNAAAALIAAGAAEGFPSAVRNAEESIDGGKAIEKLEALVRYTNEN
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: CSS1_SCHPO
Sequence: MSVEKAPELRVLSFNCWGLRFVSKYRTERLKAVGEKLAKCDYDIVLLQEVWSIYDFQEIRNLVSCNLVYSRFFHSAAMGAGLAMFSKFPIIESSMNKYPLNGRPQAFWRGDWYVGKGVATASLQHPSGRIISLFNTHLHAPYGKGADTYLCHRLSQAWYISKLLRAAVQRGHIVIAAGDFNIQPLSVPHEIITSYGLVNDAWLSVYPDQVEHPPNRFSMNDKELVEIAGTTCDSRLNTWRENISSKDMDDFVAKRLDYVFHSPSTCEAKNAKVVFLERVPKLDCSYSDHFAIETVLSIKLQPIPVQETRVSYSIIDDTLGITYQYMARERLHMRLRIAHLLISIPLIIGVHVAIAWCDPAWLKVIILFFTVMLTIAAVVNGFCIGLLFGRWEFNGLLEFVAELKEQKLLCKQYLVDHPLPFAKS
What is the function of this protein?
Inositol phosphosphingolipids phospholipase essential for the coordination of cell wall formation.  Responsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C).
What are the official names of this protein?
Inositol phosphosphingolipids phospholipase C, IPS phospholipase C, IPS-PLC.
What is the protein family that this protein belongs to?
Belongs to the neutral sphingomyelinase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RIMP_STRZP
Sequence: MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVDKPEGITLNDTADLTEMISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGKYIHVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVQIPYSLVSKARLAVKL
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIT_CALJA
Sequence: MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPEEASPPFIDPAKSELIVSVGDEIRLFCNDPGFVKWTFEVLDQMNENKQKEWIMQKAEATNTGKYTCTNKHGLSSSIYVFVRDPDKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPIPKDLRFVPDPKAGITIKNVKRAYHRLCLHCSADRKGQSKLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSSWKKENSPTKLQEKYNSWHQGDFNYERQATLTISSVRVNDSGVFMCYASNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPRPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKDTEGGTYTFLVSNSDVSSSIAFTVYVNTKPEILTYDRLMNGMLQCVAAGFPEPTIDWYFCPGTEQRCSAPVLPVDVQIQNTSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKEQIQPHTLFTPLLIGFVVVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDTAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKAEKRRSARVGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLTNCSPSQQKPVVDHSVRINSVGSTASSSQPLLVRDDV
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.  In response to KITLG/SCF binding, KIT can activate several signaling pathways.  Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL.  Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase.  Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1.  Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor.  Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.  Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
What are the official names of this protein?
Mast/stem cell growth factor receptor Kit, SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RISB_PEDPA
Sequence: MTEYLGTFNGSKLKIAIIVARFNDLVTKRLLDGAFQTLAQNGVSKEDIDIYWVPGAFEIPRVAQKISQKGNVDGIITLGAVVRGETSHYESVCSGVTSGIAQIALEGKVPVMFGVLMTENMEQALNRAGGKAGNKGSECATGLLEMIDIEQTIDRE
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: MEND_DESHD
Sequence: MTNYIAALVDELYQLGVREAVISPGSRSTPLSVLFCEYGFQVYVGIDERSAGFFALGIAKEKERPVVLVCSSGSAVAHYFPAIVEAKHSHVPLIVLTADRPPELRQVGAPQTIDQIKFYHDYAKYFEELALPEEREGMYRYVRGVMRKAYVSSLDQGYGVAHINIPLREPLSPDLDGVDFTAGRLDYPFAWKTGEKGLTMDSSVFQDKKGIIICGGDPYADYHREVLELAERLKAPLLADPLANFRNDDHPLIMDCYDAFLKSDAVKVELKPEFIIHFGQTPVSKRLQNFTAMHQDVLYFQVNDYFQYRDPSLSISRYLVASPKAFARSVKVHNTDDGYSGRWQHYQARMRRRLNLAQDEEELFEGKLVQKLQDSLPEGSRLFVANSMAIRDVDYFLEARRQRIKVLGNRGANGIDGTVSTALGVATSGHPTVLLTGDLAFFHDLNGLLIGKNHGLNLIIVLLNNNGGAIFKYLPQSENKYFELLFMTPHGMDFSGLKTLYDLTYYEPVDYESFAQNFQEALTLSGVKVLNVKIDARLSKELHDRLTNLD
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.