PharMolix/UniProtQA huggingface dataset:
Protein: POLH_HUMAN
Sequence: MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSLESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPFQTSQSTGTEPFFKQKSLLLKQKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPVCEGVSKLEESSKATPAEMDLAHNSQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEHMDYHFALELQKSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPRPEGMQTLESFFKPLTH
What is the function of this protein?
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261).  Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions.  Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex.  In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906).  Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006).  Although inserts the correct base, may cause base transitions and transversions depending upon the context.  May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526).  Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue.  This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940).  Targets POLI to replication foci (PubMed:12606586).
What are the official names of this protein?
DNA polymerase eta, RAD30 homolog A, Xeroderma pigmentosum variant type protein.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Nucleus. Note=Binding to ubiquitinated PCNA mediates colocalization to replication foci during DNA replication and persists at sites of stalled replication forks following UV irradiation (PubMed:12606586, PubMed:16357261, PubMed:24553286). After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80%; this recruitment may not be not restricted to cells active in DNA replication (PubMed:22801543). Colocalizes with TRAIP to nuclear foci (PubMed:24553286).
Protein: PANC_RHOJR
Sequence: MSDLQGGYKRGELTVHHDPSVLTRVSKALRGVGRQVALVPTMGALHTGHLELVRQAKLTGAVVIVSIFVNPLQFGAGEDLDAYPRTLDADLELLREAGVELAFVPTAATMYPAGPRTTIHPGPLGAELEGVSRPTHFAGMLTVVAKLLQIAAPNVAYFGEKDYQQLTLIRQMVTDLNFDVRIFGVPTVREHDGLALSSRNRYLDEAQRSAATALSAALIAGAHAAAGGAEAILATAREVLASVPEVEVDYLEVRGVDLGPAPERGDGRLLVAAKVGTTRLIDNVGVAVGTGFLERDAEPPSDASAADELLSR
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: D19P2_HUMAN
Sequence: MADSRRVIIASWYRTFMGIVNLFGLETKTCWNVTRIEPLNEVQSCEGLRDPACFYVGVIFILNGLMMGLFFIYGTYLSGTELGGLITVLCFFFNHGEATCVMWTPPLRESFSYPFLVLQMYVLTLILRTSSNDRRPFIALCLSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKIIYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAIILKRNEIQKLGVSKLNCWLIQGSAWWCGTIILKFLTSKILGVSDHICLSDLIAAGILRYTDFDTLKYTCSPEFDFMEKATLLIYTKTLLLPVVMVITCFIFKKTVGDISRVLATNVYLRCCLCRCHAYNGKCQAVYTSSHCESSTLRRCRLEAWLQHA
What is the function of this protein?
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
What are the official names of this protein?
Putative C-mannosyltransferase DPY19L2P2, Dpy-19-like protein 2 pseudogene 2, Protein dpy-19 homolog 2-like 2.
What is the protein family that this protein belongs to?
Belongs to the dpy-19 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RSMB_SALDC
Sequence: MKKQNNLRSLAAQAVEQVVEQGQSLSNVLPPLQQKVADKDKALLQELCFGVLRTLSQLEWLINKLMSRPMTGKQRTVHYLIMVGFYQLLYTRVPPHAALAETVEGAVSIKRPQLKGLINGVLRQFQRQQETLLNEFATSDARFLHPGWLVKRLQNAYPTQWQRIIEANNQRPPMWLRVNRTHHTRDGWLGLLEDAGMKGYPHPDYPDAVRLETPAPVHALPGFAEGWVTVQDASAQGCAVFLAPQNGEHILDLCSAPGGKTTHILEVAPEADVLAVDIDEQRLSRVYDNLKRLGMKATVKQGDGRYPAQWCGEQQFDRILLDAPCSATGVIRRHPDIKWLRRDRDIVELAQLQAEILDAVWPRLKPGGTLVYATCSVLPEENRDQIKTFLQRTPDAALSETGTPDQPGQQNLPGGEEGDGFFYAKLIKK
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y202_MYCGE
Sequence: MSEQKRRTIQIAISEDHYEELQKALELLKGTQLPFSTTVEQFVELILSNYVATSNKISSLAKSGFDVASLQQELEKIGNLSGVDDNLKGFLSELLKTSRNGFSNPNKDGKKNDDDNNSSSKS
What are the official names of this protein?
Uncharacterized protein MG202.
Protein: Y146_MYCTU
Sequence: MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEERRAEMRARFKKVADVLGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVEGVPMADDPTAFAEFVTAERL
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0146.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: PER_DROPU
Sequence: SSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVESSYVSSARGEDARSTLSPVQGFEGSGGSGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGDGGGGGGANGTGSGAAPPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGEKNKKSANEAMKMLEYSGPGPGHGHGIKRGGSHSWEGEANKPKQQLTLNTIGGGGGGGVGGGMPLFLDITHASSSSQNKGLAGVGVGGAGGVVGGGGSGTGLGGNGNVGSGNGNNNQPSTNQYTQSRLPCTQNINLWPPFSVGITTPTSVLSSHTAVPPSSFSPQHSLFPTFYYIPASIAASSPSSTNTNPNRPHKHAHVHNSSEKPSTSQAAAATMPLQYMTGVMYPHPSLFYTHPAAAAATAMV
What is the function of this protein?
Essential for biological clock functions.  Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms.  Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system.  The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex.  Light induces the degradation of TIM, which promotes elimination of PER.  Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop.  Behaves as a negative element in circadian transcriptional loop.  Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
What are the official names of this protein?
Period circadian protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization (By similarity).
Protein: Y873_CHLMU
Sequence: MTTKSKTLEIDNNTFLLLEGNLKRIFATPIGYTTFREFQNVIFNCAQGQQELANFLFEMLINGKLLQELPAGQKQSAQSLIVQFMMLIRVAKDIHERGEFINFITSDMLAQQERCVFLNRLSRVDGQEFLLMTDVQNTCHLIRHLLSRLLEAQKNPIGEKNLQEVQEDLDSLRAHFEELTKSM
What are the official names of this protein?
Uncharacterized protein TC_0873.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0803/CT_584/TC_0873 family.
Protein: IF5_PHAVU
Sequence: MALQNIGAGNSDDAFYRYKMPRMVTKIEGRGNGIKTNVVNMVDIAKRLARPASYTTKYFGCELGAQSKFDEKTGTSHVNGAHETAKLAGLLEIFIKKYVQCYGCGNPETEILITKNQMIQLKCAACGFVSDVDMRDKLTTFIVKNPPEVKKGSKDKKAMRRAEKERLKEGEAADEELKKVKKEVKKKGSSSAKDGTAKSTISKKKGSGSDEDRRSPTHKQIEEKEEAKDEDDDDDDGVQWLTDTSLDASRQRIKEQLSAVTADMVMLTTDEPEKKKKAASNQNGGSQNGNSKNYGTVVAEVKANLKKGFGASELLSHLAALPVPAQEKMSALVEALFEGTEKGFGRETLKKKNYFAAAVAEEGSQILLLHAIEEFCCKPNSNALKEVALVLKTLYDADVLEEEAIVLWYQKGLKGDNKNSKIWKNAQPFIDWLQNAESESDEE
What is the function of this protein?
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S. mRNA. Met-tRNA[F]. eIF-2. GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide.  The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S. mRNA. Met-tRNA[F]).
What are the official names of this protein?
Eukaryotic translation initiation factor 5, eIF-5.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: HIS6_BURCJ
Sequence: MALAKRIIPCLDVTAGRVVKGVNFVELRDAGDPVEIARRYDDQGADELTFLDITATSDQRDLILPIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVSMNSSAVANPQLVRDAADKYGSQCIVVAIDAKRVSADGEAPRWEVFTHGGRKNTGLDAIEWARKMAELGAGEILLTSMDRDGTKSGFDLALTRGVSDAVPVPVIASGGVGSLQHLADGIKDGRADAVLAASIFHYGEHTVGEAKRFMSDQGIAVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVG_ECOLI
Sequence: MNGAQWVVHALRAQGVNTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIATSGPGATNLITGLADALLDSIPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLEELPRIMAEAFDVACSGRPGPVLVDIPKDIQLASGDLEPWFTTVENEVTFPHAEVEQARQMLAKAQKPMLYVGGGVGMAQAVPALREFLAATKMPATCTLKGLGAVEADYPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPHASVIHMDIDPAEMNKLRQAHVALQGDLNALLPALQQPLNQYDWQQHCAQLRDEHSWRYDHPGDAIYAPLLLKQLSDRKPADCVVTTDVGQHQMWAAQHIAHTRPENFITSSGLGTMGFGLPAAVGAQVARPNDTVVCISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTDNPDFLMLASAFGIHGQHITRKDQVEAALDTMLNSDGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS
What is the function of this protein?
Catalyzes the first step in the biosynthesis of branched-chain amino acids.
What are the official names of this protein?
Acetolactate synthase isozyme 2 large subunit, AHAS-II, ALS-II, Acetohydroxy-acid synthase II large subunit.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: F16P1_SHEEP
Sequence: MTDEAPFDTNIVTVTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGTTNVTGDQVKKLDVLSNDLVVNVLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYKKISKDDPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSLNEGYAKDFDPALTEYVQRKKFPPDNSAPYGSRYVGSMVADVHRTLVYGGIFMYPADKKSPSGKLRLLYECDPMAYVIEKAGGMATTGKEAVLDIVPTDIHQKVPIILGSPEDVTEFLEIKKYTAK
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis.  Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells.  Appears to modulate glycerol gluconeogenesis in liver.  Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
What are the official names of this protein?
Fructose-1,6-bisphosphatase 1, FBPase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, Liver FBPase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
Protein: KTHY_STAAW
Sequence: MSAFITFEGPEGSGKTTVINKVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGNDMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEKI
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: LPXB_SALEP
Sequence: MAAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTRRFTELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQFEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTEYVSLPNLLAGRELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAADAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: RK12_POPEU
Sequence: LGAEISSLTLEEAR
What are the official names of this protein?
50S ribosomal protein L12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HTPX2_METMA
Sequence: MKRKWERDLGLQGRMLFTMFLLAAVYLFFLAFLSYYGTSQIFIILFIGLFMAAQYFYSDKMVLWTTGAQIVSESEAPQLHGMITRLCAIADLPKPQVAIVRTQVPNAFATGRNQNKAVVAVTTGLMDKLSPAELEAVLAHELSHVKNRDMAVLTIASFLSSVAFYIVRYSLYFGNMGGGRRKEGGGIMLVWLVSIVVWIVSFLLIRALSRYREFSADRGAAVITGQPANLASALMKISGVMDRVPGDDLRKVEGMNAFFIIPAISGSSIMDIFSTHPSVEKRIAKLEKMQQEMS
What are the official names of this protein?
Protease HtpX homolog 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HUTH_KLEP7
Sequence: MKSLTLIPGQLSLSQLRDIYSHPVNITLDSGAFAAIDESVACVNAILAEGRTAYGINTGFGLLAQTRISTEDLENLQRSLVLSHAAGVGEPLDDDLARLIMVLKINSLSRGFSGIRLSVIQALIGLVNAGVTPWIPAKGSVGASGDLAPLAHMSLTLLGEGKARVRGGDWLPATEALRQVGLEPITLAAKEGLALLNGTQASTAFALRGLFEAEDLFASAVVCGALTTEAALGSRRPFDARIHEVRGQRGQIDAAALYRHLLTDDSAISQSHHNCSKVQDPYSLRCQPQVMGACLTQIRQAAEVLLAEANAVSDNPLVFAAENDVISGGNFHAEPVAMAADNIALAIAEIGSLSERRIALMMDSHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALSHPHSVDSLPTSANQEDHVSMAPAAGRRLWAMAENTRGVLAVEWLAAAQGLDMREGLTTSPLLEEARHLLRERVPHYTQDRYFAPDIDNAIALLAARHLTRLLPAVLH
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL12B_LAMGL
Sequence: MHPQQLVVSWFSLVLLASPIMAIWELEKNVYVVELDWYPDAPGETVVLTCDTPEEDGITWTSDHSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGVWSTDILKKDQKEPKSKTFLKCEAKNYSGHFTCWWLTAVSTDLKFSVKSSRGSSDPRGVTCGAATLSAERVGVEHRDSWKYTVECQEGSSCPAAEESLPIELVVEAVHKLKYENYSSSFFIRDIIRPDPPKNLQLKPLKNSRHVEVSWEYPDTWSTPHSYFSLTFCVQVQGKHKREKKDKLFVDQTSAKVTCPKDASIRVQARDRYYSSSWSEWASVSCS
What is the function of this protein?
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.  IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.  IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines.  IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
What are the official names of this protein?
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40.
What is the protein family that this protein belongs to?
Belongs to the IL-12B family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACCD_SYNY3
Sequence: MSLFDWFANREKAEPPVLQPQSPQEREVADGLWTKCPACGVLTYTKDLQGNWMVCVECGHHLRVDSDERIRQLIDAKTWQPINEHLRPTDPLKFKDRKSYKDRIRDTQKATDLTDAVQTGHGRLDGLPIALGVMDFRFMGGSMGSVVGEKLCRLIEYATLERLPVVIICASGGARMQEGMLSLMQMAKISGALQNHREQKLLYIPVLTHPTTGGVTASFAMLGDLILAEPKATIGFAGRRVIEQTLREKLPDDFQTSEYLLHHGFVDAIVPRPQLKRTLAQLISLHQPFYPILPPLNADSNQVNPELVLSHTALAVDNQISVNQDG
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_BACVZ
Sequence: MNHDYRTIDLFGLTFNLTNILMITVASVIVLLIAILTTRTLSIRPGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSVTVGHELWWKSPTADPAITLTLAVMVVSLTHYYGVKMKGLKEYSKDYLRPVPLMFPMKIIEEFANTLTLGLRLYGNIFAGEILLGLLANLATNFYSNSFFLGLVGTVGAIIPMLAWQAFSLFIGTIQAFIFTMLTMVYMSHKISHDH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: WAV3_ARATH
Sequence: MGTGWRRAFCTTAPRNSDAAAPDLDKQRTGYNLTPSPSPRSCVKLAFLSGGSNPSTPRSTSSPSLRCRTADAQTPTAEQTSTPRSATKSPRLSLAAISNPSSPRSPLKLSLFRNSFKFRSTCGICLNSVKTGQGTAKYTAECSHAFHFPCIADYVRKQGKLVCPVCNSIWKDASLLVPHKNATESPLDDSVSVIQEKRVVVTSSPRAKPRPKQSDYSRFYDDDEPLLSPRFVTIPEADENCGGEEEDDVPQFKGFVVDPNPSFAVKTNEIPVNGRDFGNVQVSLLPEAAVVSVGCGYETRAVALRVKAPPPLTARGGVGRRLLDPSQRAPVDLVVVVDVGGTMNGAKLQMVKRAMRLVISSLGSADRLSIVAVVMTVPKRLLPLKRMTEHGKRSAGAVVDGLLCGQGSNTSEALKKASRVLEDRRERNPVASIVLLTDGQGQLSKVHTNQRSTITNVGSTRFAHIEIPVTEHGFGESGGCSNAPAEEAFAKCIGGLLSVVVQDLRIQIRVGSGSGPCEISAIYLCNGRPTLVSSGSGSVRLGDLYAGEERELLVELRVPSTATRAYQILSVRGLFKDPSTQEVVYGRDQSLRVPQAVRSSSSPRIERLRSLFIATRAVAESRRLVEYGECTSAYHLLTSARALLGQSGTVEAAEYIKVVEAELVEVQWRGQQLMEYQSQHQQQHNQRRRGSERETTTTMTLMDENGEPLTPASAWRAAEKLAKLAMMKKSDLHGFENARF
What is the function of this protein?
E3 ubiquitin-protein ligase involved in the regulation of root growth.  Acts as positive regulator of root gravitropism.  Possesses E3 protein ligase activity in vitro.
What are the official names of this protein?
E3 ubiquitin-protein ligase WAV3, Protein WAVY GROWTH 3, RING-type E3 ubiquitin transferase WAV3.
Protein: LEU1_CUPTR
Sequence: MLVNPATKYRPAATVDIPDRTWPGRTITRAPRWMSTDLRDGNQALIEPMNPARKLRLFEQLVKIGLKEIEVAFPAASQTDFDFVRMLIEERRIPDDVTIVVLTQSREDLIRRTVESVRGAARATVHLYNPIAPAWRRIVFNASRDEIKAVAVSGTRLIKALTDAMPETAWTYEYSPETFSLAELDFSLEVSDAVSAAWQAGPGRPMILNLPTTVECSTPNVFADQIEWMHRRLARRAHIVLSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVAPELDFSDIDAVRQCVEHCNQLPVHPRHPYVGDLVFTAFSGSHQDAIRKGFAQQQPDAIWEVPYLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQVHGLYLPRRLQIEFSRAVQAMTDDTGLEASADDLYGLFRREYLARETPLRYVSHQLASDATGATAITVQMERDGQPCTVRGTGNGPIDAFIDALDLPVRVMDYHEHAMTAGADARAACYVEVRVGDSPTGFGAGIDASLVTASLRAVVSGVNRHLQAGFGARAQATQTASASAATEA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: APAH_ACTP2
Sequence: MATYIVGDLHGCFDELQLLLKQVNYNPAQDELWLTGDLVARGAKSLECLRFVKDPKNNAKTILGNHDLHLLATLLGVKKVKPNDQVDAIFAAEDRADLQNWLRNQPLLIQHPKYGFLLTHAGISPEWNLTETIACAREAEAVLQSGHYADYIAQMYENTPDHWSAEWQGIERWRYIINVFTRMRFCYADKRLDFACKLPVEDAPNELKPWFKLDNPLFHQQDIIFGHWASLMGKADKPNIYALDTGCAWGNHLTMIRWEDKQIFTQERLK
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: PSG9_HUMAN
Sequence: MGPLPAPSCTQRITWKGLLLTASLLNFWNPPTTAEVTIEAQPPKVSEGKDVLLLVHNLPQNLPGYFWYKGEMTDLYHYIISYIVDGKIIIYGPAYSGRETVYSNASLLIQNVTRKDAGTYTLHIIKRGDETREEIRHFTFTLYLETPKPYISSSNLNPREAMEAVRLICDPETLDASYLWWMNGQSLPVTHRLQLSKTNRTLYLFGVTKYIAGPYECEIRNPVSASRSDPVTLNLLPKLPIPYITINNLNPRENKDVLAFTCEPKSENYTYIWWLNGQSLPVSPGVKRPIENRILILPSVTRNETGPYQCEIRDRYGGLRSNPVILNVLYGPDLPRIYPSFTYYRSGENLDLSCFTESNPPAEYFWTINGKFQQSGQKLFIPQITRNHSGLYACSVHNSATGKEISKSMTVKVSGPCHGDLTESQS
What is the function of this protein?
Binds to the small latent transforming growth factor-beta complex, consisting of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1, thereby leading to the activation of TGFB1 (PubMed:27389696).  The activation of TGFB1 leads to stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to an increase in the number of FoxP3(+) regulatory T-cells (PubMed:27389696).  Induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset (PubMed:27389696).  Induces the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells (PubMed:27389696).  May reduce the expression of several pro-inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2 and IL6 (PubMed:27389696).
What are the official names of this protein?
Pregnancy-specific beta-1-glycoprotein 9, PS-beta-G-9, PSBG-9, Pregnancy-specific glycoprotein 9, PS34, Pregnancy-specific beta-1 glycoprotein B, PS-beta-B, Pregnancy-specific beta-1-glycoprotein 11, PS-beta-G-11, PSBG-11, Pregnancy-specific glycoprotein 11, Pregnancy-specific glycoprotein 7, PSG7.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. CEA family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPA2_ARATH
Sequence: MALQIHSPCSFSTRPYHLFFTTRNPRFAIKCQNSQIESDTTEDPSRSKNSSSSGVGFGSPASSSSPAKKLSAATSGNKKGKGKREVNRRAPVEKPVFMSEEGAAKAEEQRQNENAFLLTWLGLGIVILIEGIILAASGFLPEELDKLFVKYVYPVFTPSVVLFVAGTTAYGVLKYIQNEKMKGQE
What are the official names of this protein?
Protein LPA2, Protein LOW PSII ACCUMULATION 2, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: HFLD_XANOM
Sequence: MSVSMDHRVLALAGVAQALQQVRRIAETGHSEAATVRTAMDSVFRVDAASPEAVYGSAAAVAPGLRLLHNYFRNQGQDDVLPRLALAVLQLERRFVRDTATVATVASGIDAAARQAQQLGDSNHPDVLSSLGGLYAQTISHLRPKVMVQGNPHYLGQAGVVAEIRALLLAAVRSAVLWRQMGGSLWDFLFAKRAMIEAVDRALR
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.