PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_COXB1
Sequence: MNGVEVPAKIQKRIERLREEINDHNYRYYVLSQPTIPDSVYDELFHELQKLEKKYPETITPSSPTQRVGAEPLKVFEPVHHEIPMLSLDNVFDEKGLRAFDKRIRQRLKLDKPFEYVCEPKMDGVALSLLYENGELIRAATRGDGYTGENVTQNTRTIASVPLQLRGNDYPELVEIRGEVLMPREGFAKFNREAEKRGDKTFANPRNAASGSLRQLDPRITAKRPLIFYGYLIGLLKGKDFPKNHCDVLKWFKDWGIPVISEIKVVGGIEGCLDYYEHLVKTREKMPFDIDGIVIKVNSLQVQAELGFVSRAPRWAIAYKFPAQEKMTVVKAIEFQVGRTGAVTPVARLEPVSVSGVTVSNATLHNFDELYRKDVRVGDTVIVRRAGDVIPEVVGPILAKRPKKAKLIKIPSRCPVCHAEVIKPEGEAVARCMGGLYCRAQLRESIKHFASRRALDIEGLGDKLVELFIQEKLIKDITGIYQLKKSAITALPRMGEKSAENLLTAIEKSKKTTLPRFLYALGIRGVGDTTARTLARHFHELDLLMKASIETLQEIRDIGPVVAENIHAFFHQKHNAELINKLIHLGVHWPQEKAVVKSEIAGKTFVLTGALKSLTREEAEEKIERSGGKATSSVSKNTDYVIVGENPGSKYEKAKALGISLIDEEAFLKLLKS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: NUOK_XYLFA
Sequence: MISLGHLLVLGAALFCISLAGIFLNRKNVIVLLMSIELMLLAVNVNFIAFSRQLGDTAGQLFVFFILTVAAAEAAIGLAILVTLFRTRHTINVAEVDALKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL18_LACPL
Sequence: MISKPDKNKTRQRRHARVRGKISGTAERPRLNVYRSNKNIYAQVIDDVEGVTLASASTLDSEVKGNNKTEKAASVGEVVAKRAAEKKIVDVVFDRGGYLYHGRVQALAEAARENGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: HSL23_DICDI
Sequence: MTIIASISKIGNIKSSSSSSIGSGRNSAISFGSNKIACGECGGSSNPMGSLIGNVANTGAGKVSHIPVTVMVDASVAMNPSSMLPSGGSCGCN
What are the official names of this protein?
HssA/B-like protein 23.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: SYR_METPE
Sequence: MFTETYTLIERVLKACTDETEIALTDGGEHADLASTVAFALAKKRHQAPKVIAEELAVTLAANPELAGIRVEALGPYLNFSFGPKYLEETLKAAVQDNFGTAPTKPVRIVLEHTSANPNGPLHVGHIRNSILGDTLARAFRKAGYRVEVQYYVNDMGRQIAIVAYGFDHLDTGAKPGEKADHHIARVYVAANRDLEANPDKGAEIDERMQLIEKRDPATATQFRELVSRCLDGFKVTMQGLNVKHDRFIWESDFVKIGDMEKVLGRLAKIPQAVPPTEEDGTFSLDLSSCGYKKSYVLRRSDGTSVYAARDLAYHIWKGRNFDRVIDVLGADHKLITGQLVCTLRLIAEKPPEVVHFEFVSLPEGSMSTRAGTFVSADELIEEMQKRAIEEVQVRRPEIPVEERDAIAASVARAAIRYDIIKVSPEKSTVFDWKEALDFDRQSGPYVQYAHARACSILDRAGPFQERYDLLESPYEIALVKHIAKFPSIIESVVRDLRPHMLATYARDLADLFNTFYHYDPVLKGEGPVRESRLTLVLAAEKTLKEVLETLGIDALRSM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECFA2_STAAN
Sequence: MTIRFDNVSYTYQKGTPYQHQAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRPVRKRIGMVFQFPESQLFEDTVEREMIFGPKNFKMNLDEAKNYAHRLLMDLGFSRDVMSQSPFQMSGGQMRKIAIVSILAMNPDIIVVDEPTAGLDPQSKRQVMRLLKSLQTDENKAIILISHDMNEVARYADEVIVMKEGSIVSQTSPKELFKDKKKLADWHIGLPEIVQLQYDFEQKYQTKLKDIALTEEAFVSLYKEWQHEK
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ATPA_MYCS2
Sequence: MAELTISAADIEGAIEDYVSSFSADTEREEIGTVIDAGDGIAHVEGLPSVMTQELLEFPGGVLGVALNLDEHSVGAVILGEFEKIEEGQQVKRTGEVLSVPVGDAFLGRVVNPLGQPIDGQGDIAAETRRALELQAPSVVQRQSVSEPLQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTAVCVDTILNQREAWLTGDPKQQVRCVYVAIGQKGTTIASVKRALEEGGAMEYTTIVAAPASDAAGFKWLAPYTGSAIGQHWMYNGKHVLIVFDDLSKQADAYRAISLLLRRPPGREAFPGDVFYLHSRLLERCAKLSDELGGGSMTGLPIIETKANDISAFIPTNVISITDGQCFLESDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAFAAFASDLDAASKAQLDRGARLVELLKQPQYSPLAVEEQVVAIFLGTQGHLDSVPVEDVQRFESELLEHVKASHSDIFDGIRETKKLSEEAEEKLVSVINEFKKGFQASDGSSVVVSENAEALDPEDLEKESVKVRKPAPKKA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PYRB_HELAH
Sequence: MPKQCRHLLQTSDLSMDEIKLLLKKASVYANDFNAVSLEVKEKIHNKIIVALFFENSTRTVSSFEIASLRLGAKMVKLNMQTSSTSKGETLIDTFKNIHAMQPDAIIMRHAFSSAPFKLVEFSQCPLINAGSGTSAHPTQALLDLLTLYQHFGSLENLKGKKIAFIGDVKNSRVANSNIKLLQRLGLEIMLCAPSSMLPSTPLIKTTHHIGEAIEFADILMSLRTQTERHNTPIFASLKDYANAYCITQKRLYDHAKNKEVVILHPGPVHRDIDIESTMLEDRRSKVLEQVKNGVAMRMAVLEFLLVD
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RS10_BACC3
Sequence: MAKEKIRIRLKAYDHRILDQSAEKIVETAKRSGATVSGPIPLPTEKTVYTILRAVHKYKDSREQFEMRTHKRLIDIVSPTPQTVDSLMRLDLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: GLPG_YERPB
Sequence: MTRVIVISNLRLAQAFVDYMATHHVALEIRPDAQGVEIWLADDEQLSAVQHELEQFLLDPLNPRYQAASWQAGNVNSNLPYQRFSYLQTLRSQAGPLTLSVMVLCIAIYILMLITGDMAVMSWLAWPYNSSQYLQIWRWVSHAFLHFSLLHILFNLMWWWYLGGQMEKRLGTSKLLVLTIVSAVFSGWGQSLFSGANFGGLSGVVYALMGYVWLTGERAPERGISLPRGLMAFSVLWLIAGYFDILGLSIANAAHVSGLIIGLLMAFWDTRNSARTVQ
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL2_ACTPJ
Sequence: MAIVKCKPTSAGRRHVVKVVNAELHKGKPYAPLLDSKSKTGGRNNLGRITTRHIGGGHKQHYRLVDFKRNKLDIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLSVGDTIQAGVSAPIKAGNALPMRNIPVGTTVHNVELKPGKGGQIARSAGAYVQIIAREGNYVTLRLRSGEMRKVLAECTATIGEVGNSEHMLRVLGKAGANRWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRHNKRTDKYIVRRRGK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: FIMA3_PORGN
Sequence: MKKTKFFLLGLAALAMTACNKDNEAEPVTESNATISVVLKTSNPNRAFGNAGDEAKVAKLTVMVYKGEQQEAIKSVENAIKVENIKCGAGQRTLVVMANTGGMELAGKTLAEVKALTTELTEGNQEAAGLIMTAEPVEVTLVAGNNYYGYDGSQGGNQISQGTPLEIKRVHARIAFTKIEVTMSQSYANKYNFAPENIYALVAKKKSNLFGASLANSDDAYLTGSLTTFNGAYSPANYTHVDWLGRDYTEIGAATVNTPKGFYVLESTYAQNAGLRPTILCVKGKLTKHDGTALSSEEMTAAFNAGWIVANNDPTTYYPVLVNFESNNYTYTGEAVEKGKIVRNHKFDINLTITGPGTNNPENPITESANLNVNCVVAAWKGVVQNVIW
What is the function of this protein?
Structural subunit of the major fimbriae (Probable).  These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome.  They play an important role in the invasion of periodontal tissues.  Fimbriae and their constituents are major virulence factors.  FimA proteins from different strains have highly divergent sequences, and this has been used for classification.  The sequence-based classification correlates with pathogenicity.
What are the official names of this protein?
Major fimbrium subunit FimA type-3, Fimbrillin, Fimbrilin, Major fimbrial subunit protein type III.
What is the protein family that this protein belongs to?
Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.
What are the subcellular locations of this protein?
Fimbrium. Cell outer membrane. Note=Synthesized as palmitoylated precursor. The lipidated propeptide is removed during processing to the mature protein.
Protein: HSPQ_SHIDS
Sequence: MIASKFGIGQQVRHSLLGYLGVVVDIDPVYSLSEPSPDELAVNDELRAAPWYHVVMEDDNGLPVHTYLAEAQLSSELQDERPEQPSMDELAQTIRKQRQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAB_AERHY
Sequence: MSSQHFQGRFEVEFKYRLSDVDAFTCALAALNPEVMLEDNQEQDSYFDTPEHSLAAEGKSLVIRTMQPSGIQLWIVKGPEADRCEAVNITDADKAASMLRTLGYRQVLAISKRRSIYFVGPFHVTRDHLEGIGDFAELAIMTDDEALLPDYRQQLQDLATRLGLSSAQLETRSYRTLCEQSLTLNSEKVPS
What is the function of this protein?
In vitro, CyaB catalyzes the biosynthesis of cyclic AMP (cAMP) from ATP.  It seems that under the physiological conditions CyaB has no function in cAMP processes.  In vitro, it is also able to hydrolyze substrates such as thiamine triphosphate (ThTP) and inorganic triphosphate (PPPi) at a low rate.  It has a slight preference for ThTP over ATP and PPPi in the presence of manganese ions.  This PPPase activity is probably not of physiological importance.
What are the official names of this protein?
Adenylate cyclase CyaB, ATP pyrophosphate-lyase, Adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase CyaB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_BACVZ
Sequence: MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDDTDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYWEKVFQYFLDEYKAGRTPNPDVMCNKEIKFKAFLDHALSLGADYLATGHYARVDRSAGTVRMLRGLDENKDQTYFLNQLNQEQLSKVMFPIGDLQKSRVREIAKEAELATAAKKDSTGICFIGERNFKTFLSQYLPAQPGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHNPLLYSDKITATNVSWTRPGLMDGGEMTCTAKFRYRQEDHKVTVKMTGDDEAEVIFDGQVRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF8_BOVIN
Sequence: MADAAATAGAAGSGTRSGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEMQQMEETDSSEQDEQTDTENLPLHISPDDSGAEKENTSVLQQNPSLSGSRNGEESIIDNPYLRPVKKPKIRRKKSLS
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.  TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC).  The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13.  The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C.  TAF8 is involved in forming the TFIID-B module, together with TAF5.  Mediates both basal and activator-dependent transcription.  Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts.  Required for the integration of TAF10 in the TAF complex (By similarity).  May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 8, TBP-associated factor 8.
What is the protein family that this protein belongs to?
Belongs to the TAF8 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell.
Protein: IF2_RHOPB
Sequence: MVDTKNPGDKTLSVSPSKTLTLKRGVEQGTVRQSFSHGRTKQVVVEKRGKRRVGGDGPADAPAAPAPVAAAKPAPVRAPMSRPPQSSHRGGGSGVVLRTLTEDERTARASALADARIRDEEERKAAEAELARRNSKEGIEQAEREAAEARKKAEEERHRQDEEAKRKAELEAKKRFGEEEAKKAAAAAPAKTTAATTATAAKPGAPARAPGVAADATDEDEGPRQIRRGPGGAARPVVAPKPTAKPAPAKQRGRLTLVTALSADDVRERSIASFRRRTQRLKGHQSNEPKEKLVREVIIPEAITIQELANRMAERAVDVIRMLMKQGQMVKITDVIDADTAQLIAEELGHSVKRVAASDVEEGLFDIVDDATDTEPRSPVVTVMGHVDHGKTSLLDALRHANVVSGEAGGITQHIGAYQVTSPESGKKITFIDTPGHAAFTAMRARGAKVTDIVVLVVAADDGVMPQTIEAINHAKAAKVPVIVAINKIDKQDAKPERVRTELLQYGIQVESLGGDVVDVEVSAKNKTNLDKLLEMIALQAELLDLKTNTERPAEGTVIEAKLDRGRGPVATVLVQRGTLRVGDIIVAGAEMGRVRALISDQGVTLTEAGPSVPVEVLGFNGPPEAGDRMAVVDSEARARQVTSYRAHQKREKSASAVSGLRGSLEQMMSQLKTTGRKDFPLIIKADVAGSLEAILGSLEKLGTDEVTARILHAGVGGISESDVTLAEGFNAAIIGFNVRAHKEAAAAAKRNGIEIRYYNIIYDLVDDVKKAMSGLLAPTLRETMLGNALILEVFNISKVGKVAGCRVTDGSVERGANVRLIRDNVVVHEGKLSTLKRFKDEVKEVQSGQECGMAFENYGDMRAGDIIECYRVETIQRSL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_LEPCP
Sequence: MTRQLFVTTALPYANGKFHIGHIMEYIQADIWVRFQRLMGHQVHFVGADDAHGAPIMIAAEKAGKTPQQFVADIAAGRREYLDGFHISFDNWHSTDGPENHELAQSIYRALRDNGLIEVRSIEQFFDPEKGMFLPDRFIKGECPKCGAKDQYGDSCEVCGAVYTPTEVRNPYSALSGATPVLKSSDHYFFKLSDPRCAAYLEQWTHEGGKLQQEVINKVKEWFTKDDEGKGGLGDWDISRDAPYFGIEIPDAPGKYFYVWLDAPIGYLASLKNYFDKGGPRAKYGEARSFDEFIADPAVEQYHFIGKDITYFHTLFWPATLHFSGRKTPNNVFVHGFMTVNNGEKMSKSRGTGLDPLKYLSLGMNAEWLRYYIAAKLNAHVEDVDFNPDDFVSRVNADLVGKYINIASRAAGFLAKRFGGRLSSDLGVDGMSLLETLRAHRDTLTGLYEAREFGKALREVMGLADRVNEYVDANKPWELAKKEGADAVLHDVCSVCIEAFRLLTIYLKPVLPALAAQVESFLQVEPLTFAQAHRALGAHTIGSYQHLMQRVDPKLLDALFEPPAVEAVEPGGEDIAAEIRIDDFSKVDLRIAKIVKAEAVEGSDKLLRLTLDVGEGRTRNVFSGIKGAYKPEDLEGKFIVMVANLAPRKMKFGISEGMVLAASHADEKAQPGLFVLEPHAGATPGMRVR
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPB_SALNS
Sequence: MTEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDLGLIQRAARKIDGLGIKQVALTGEGWDTERCWAFWAGYKGPKGVRTVMWPDLDDAQRQELDNRLTIIDWVRDTINAPAEELGPEQLAQRAVDLLCSVACDSVTYRITKGEDLREQNYMGLHTVGRGSERPPVLLALDYNPTGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQHPQLIIDMATLTGAAKTALGNDYHALFSFDDTLAGRLLTSAAQENEPFWRLPLAEFHRNQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYREGWLHIDCSATYRKAPVEQWAAGATGLGVRTIANLLTA
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_SHEB9
Sequence: MSDYKFTLNLPETEFPMRGNLANREPEMLERWTKDGLYQQIRDSRIGRTPFILHDGPPYANGSIHIGHSVNKILKDIIIKSKTMSGFDAPYVPGWDCHGLPIELKVEQKVGKPGQKISAAEFREECRKYAAEQVNGQREDFIRLGVLGDWQNPYLTMDFSTEANIVRSLSKVIESGHLHKGVKPVHWCTDCGSALAEAEVEYEDKTSPAIDVAFVAADSKAVAAKFGVSDYSHPVSMVIWTTTPWTLPANRALSLSPELDYSLVEFEKDGVTQALILAEVLVESCLTRYNVESHTVLGSAKGAAFELVRFNHPFLDFDVPAILGDHVTTDAGTGIVHTAPGHGQDDFVVGQKYGLEVANPVGDNGVYKPDTEYFAGQHVFKANDNVVALLREKSALLNHVAYRHSYPHCWRHKTPIIFRATPQWFISMDNHGLRTQALKEIEQTQWIPDWGQSRIEKMVENRPDWCISRQRTWGVPITLFVNRETEELHPDSVSLMERVACRIEQQGIQAWWDLDAAELLGDEAEQYRKVTDTLDVWFDSGSTFSSVVAARPEFHGHGVDLYLEGSDQHRGWFMSSLMISTAMNGKAPYKQVLTHGFTVDGKGRKMSKSIGNVIAPQTVTNKLGADILRLWVAATDYSGEMTVSDEILNRSADAYRRIRNTARFLLANLNGFEPAKDLVAVEDMVALDRWVVRRAAALQQEIIEAYEQYNFHIVTQKLMQFCSVELGSFYLDIIKDRQYTAKQEGHARRSCQSALYLISEAMVRWIAPILSFTADEVWQLLPGERDAYVFTQEWYQGLKSVTLATDLSDDYWQQLLTVRNEVNKVIEQARRDKRIGGSLEAEVTLFADAALTEQLTHIGDELRFVLLTSEAKVLPLADATSEAVETELASLKLVVASSTAEKCERCWHHREEVGTIEAHPTLCTRCVTNIEGDGEVRLFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_GLOC7
Sequence: MSNQNGKTKLITDNRQARFLYEILETYEAGIELTGTEVKSIRAGRINLKDGYALIRNGEAWLINVHISPYEASGQYFNHDPRRTRKLLLHRKEINKLIGQVEQKGLTLVPLKMYFKDSWVKVSIGLAQGKKLHDKRETLKRRQDERDMQRAMKRW
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: M24_STRPY
Sequence: MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKRKEEN
What is the function of this protein?
This protein is one of the different antigenic serotypes of protein M.  Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis.
What are the official names of this protein?
M protein, serotype 24.
What is the protein family that this protein belongs to?
Belongs to the M protein family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor.
Protein: UL87_EBVB9
Sequence: MLAHLNQVTRIPPCPPFSGREARLKFHFFSWSTFMLSWPNNATLREIRTRAATNLTHHPHLVDTLYHASPQTPFLTRSGALYRFVTCCNCTLPNISIQQCKAGDRPGDLEIILQSNGGGRPASFQFPSSPTGSLLRCIVAASLLPEVSVGHQELSPLRSRSQGGQTDVRSGPDPARRLVALLRREDGAPKDPPLGPFGHPRGPGPAKSEDEESERRDAPPPPLDSSFQASRLVPVGPGFRLLVFNTNRVINTKLVCSEPLVKMRVCNVPRLINNFVARKYVVKETAFTVSLFFTDGVGANLAINVNISGTYLSFLLAMTSLRCFLPVEAIYPAAVSNWNSTLDLHGLENQSLVRENRSGVFWTTNFPSVVSCRDGLNVSWFKAATATISRVHGQTLEQHLIREITPIVTHREAKISRIKNRLFTLLELRNRSQIQVLHKRFLEGLLDCASLLRLDPSCINRIASEGLFDFSKRSIAHSKNRHECALLGHRHSANVTKLVVNERKTRLDILGRNANFLTRCKHQVNLRQSPIFLTLLRHIRRRLGLGRASVKREITLLLAHLRKKTAPIHCRDAQV
What is the function of this protein?
DNA-binding protein that is required for viral late gene expression (PubMed:22457524).  Selectively recognizes late promoters by binding to a non-canonical TATA box element (TATT) (PubMed:22457524, PubMed:17400302).  Part of the viral pre-initiation complex (vPIC) that is responsible for the expression of vPIC-dependent late genes (PubMed:31461506, PubMed:25165108).  vPIC is composed of at least BcRF1 that binds the viral TATT box, BDLF3. 5, BDLF4, BFRF2, BGLF3, BGLF4 and BVLF1 (PubMed:25165108).
What are the official names of this protein?
Late gene expression regulator BcRF1, TBP-like protein BcRF1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL87 family.
Protein: ITPA_MAIZE
Sequence: MSAAARVLPKAVTFVTGNAKKLEEVRAILGSSVPFQSLKLDLPELQGEPEYISKEKARIAASQVNGPVLVEDTCLCFNALKGLPGPYIKWFLEKIGHEGLNNLLKAYEDKSAFAMCIFSLALGPGEEPITFVGKTAGKIVPARGPNYFGWDPVFQPDGFEQTYAEMPKSVKNNISHRGKALALVKEHFASASYTVQSNDST
What is the function of this protein?
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm.