PharMolix/UniProtQA huggingface dataset:
Protein: PPNP1_PSYA2
Sequence: MTAAQFTNVTVNAQATISYDGRCSSHTIMFEDGRHKTLGVILPCDNLVEHYHFSTNTSERIEITGGECEVKINGEEAFSYYRAGQSFVVEGNSGFNLRTEEIVQYICHLEG
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase 1, Adenosine phosphorylase 1, Cytidine phosphorylase 1, Guanosine phosphorylase 1, Inosine phosphorylase 1, Thymidine phosphorylase 1, Uridine phosphorylase 1, Xanthosine phosphorylase 1.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: RL22_HAEI8
Sequence: METIAKHRYARTSAQKARLVADLIRGKKVAQALEILTFTNKKAAALVKKVLESAIANAEHNDGADIDDLKVAKIFVDEGPSMKRVMPRAKGRADRILKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: DNAE2_BRADU
Sequence: MNTPAYAEIGITTNFSFLRGGSDPRAYVHQASILGISAIGIADHNTLAGVVRAYKELDNDKVLHKPKLLIGARIVFIDGTPDILVYPRDRAAYGRLCQLLTRGKRGDDVTRIEKGECRLTFSDLLAFSEGQLLVLTLPHRFEPAQALDVLAKLKATRAEGVWLAASLVHRGDDRRRLARLDDLATTAKVQLLATNEVLYHDPARRPLQDVLTCIREKTTIEAVGRKLEANAERFLKTPREMSRLFRDFPDAIAETMRFANKIDFSLDQLRYQYPDEPVPPGKTAQGHLEDLTWAGVDKYFAGKIDDKLRATLKKELALIAELKYAHYFLTVHDIVHYARSQNILCQGRGSAANSAVCYVLGITSVDPTKVDLLFERFISKERLEPPDIDVDFEHSRREEVMQYVYRRYGRHRAAIIATIIHYRPRSAIRDVGKALGLTEDVTAALADTVWGSWGSGLNDMQVKQAGLDPQNPMINLAVELATELIEFPRHLSQHVGGYVLTQDRLDTYVPIGNAAMDDRTFIEWDKDDVDALNMMKVDVLALGMLTCIRKCFDLIDQHKGERWVLASVPQDDPKVYDMLCDGESLGVFQVESRAQMNMLPRLKPRTFYDLVIEVAIVRPGPIQGDMVHPYLRRRNGQEKVNYPSPSPEHGPADELYKVLHKTKGVPLFQEQAMRIAIEAAKFTSEEANGLRRSMATFRNVGTIGKYEDKLIGNMVARGYDPNFARSCFDQIKGFGSYGFPESHAASFAQLVYISSWLKYHHPDAFCCGLLNSQPMGFYAPAQIVGDARKNGVEVRDIDVSYSFAQNTLEQGSGKYCAVRLGFRQIDGFHWLDEDEEHLKRSLLSFRGAPLGANPESIGPHMPGGMDSGLDAGASPRNDKKEDWANRIVAARNRRPFTSLEDFARDTGLPKRALILLADADAFRSLGLDRREALWQVRRLPDDVPLPLFEAATAREQPDEHAKPLPLMPRPEQVVADYQTIRLSLKGHPMEFLREMLSRERVVACKDVNHQNERRRVRCAGVVLVRQRPGSASGVVFMTLEDETGIANVVVWPKIMEQYRKEVMGARLILVEGYIQSSPEKVTHLIAQRMVDRSHDLIGLANDSLTRKHPVPSGDALIEPLNDDRRDHADAPAQKIRHPRNVRILPPSRDFH
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H8A14_CYRHA
Sequence: MVNMKASMSLTFAGLVLLFVVCYASESEEKEFPKEMLSSIFAVDNDFKQEERDCAGYMRECKEKLCCSGYVCSSRWKWCVLPAPWCR
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U3-theraphotoxin-Hhn1a 14, U3-TRTX-Hhn1a, Hainantoxin-VIII.14, HNTX-VIII.14, Peptide F4-27.90.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8) subfamily. Hntx-8 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ENO_METMA
Sequence: MSYIGLQQDSGEYKIQKIHAREILDSRGNPTVEVDVFTPKGFGRASVPSGASTGTNEALELRDADPNRYGGKGVLTAVKNVNTIIQKELLGLDVRNQREIDELMIELDETENKSNLGANAILGVSMAVAKAAADSLNIPLYRYFGGSNAFTLPVPTMNVLNGGKHAGNELAIQEFMIQPKGAETFYEALQIGAEIYQTLGKFLENKYGRSSTNVGYEGGYAPKMGESTEALDALVHAIEEAGYTESEVTIGLDAAATEFYEEEFYNIDGKKLAAPELLDYYVELVNSYPILSIEDPFYEEAFEDFEALTNELWDTIIVGDDLFVTNIERLSKGVDMGAANALLLKVNQIGSISEAFDAASMASRNGYTVIVSHRSAETEDTTISDLAVAIGAEMIKTGAPARGERTAKYNQLLRIEEDLGEVAHYVQL
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: FUZZY_RAT
Sequence: MGDDGPGSTVHLLCLAASSGVPLFCRSSSGGAPSRQQLPFSVIGSLNGVHMFGQNLDVQLNSARTEDTTVVWKNFHDSITLIALSSEEGTSELKLERMLHMVFGAMVLIVGLEELTNIRNVERLKKELRASYCLIDSFLGNSELIGDLTQCVDCVIPPEGSVMQETLSGFAEATGTAFVSLLVSGRVVAATDGWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLGELDPQLLERWWQPLLEPLRACLPLGPRALPDGFPLHSDILGLLLLHLELRRCLFTVEPSKDKEPSPEQRRRLLRNFYTLVATTHFPPEPGPAEKQEDTVHPAQTPRACYLVLGPGMGWQLVAVQLGLRLLLLMLSPQTPTHGLRSLATHTLQALTPLL
What is the function of this protein?
Probable planar cell polarity effector involved in cilium biogenesis.  Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies.  May regulate protein and membrane transport to the cilium.  May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity).
What are the official names of this protein?
Protein fuzzy homolog.
What is the protein family that this protein belongs to?
Belongs to the fuzzy family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body.
Protein: SYP_ECOLI
Sequence: MRTSQYLLSTLKETPADAEVISHQLMLRAGMIRKLASGLYTWLPTGVRVLKKVENIVREEMNNAGAIEVSMPVVQPADLWQESGRWEQYGPELLRFVDRGERPFVLGPTHEEVITDLIRNELSSYKQLPLNFYQIQTKFRDEVRPRFGVMRSREFLMKDAYSFHTSQESLQETYDAMYAAYSKIFSRMGLDFRAVQADTGSIGGSASHEFQVLAQSGEDDVVFSDTSDYAANIELAEAIAPKEPRAAATQEMTLVDTPNAKTIAELVEQFNLPIEKTVKTLLVKAVEGSSFPQVALLVRGDHELNEVKAEKLPQVASPLTFATEEEIRAVVKAGPGSLGPVNMPIPVVIDRTVAAMSDFAAGANIDGKHYFGINWDRDVATPEVADIRNVVAGDPSPDGQGRLLIKRGIEVGHIFQLGTKYSEALKASVQGEDGRNQILTMGCYGIGVTRVVAAAIEQNYDERGIVWPDAIAPFQVAILPMNMHKSFRVQELAEKLYSELRAQGIEVLLDDRKERPGVMFADMELIGIPHTIVLGDRNLDNDDIEYKYRRNGEKQLIKTGDIVEYLVKQIKG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  Misacylated Cys-tRNA(Pro) is not edited by ProRS, but instead may be edited in trans by YbaK.
What are the official names of this protein?
Proline--tRNA ligase, Global RNA synthesis factor, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_RICPU
Sequence: MVHFIFVTGGVVSSLGKGLTAASLAMLLQAKGFRVSVRKLDPYLNIDPGTMNPHEHGEVYVTDDGAETDLDLGHYERFTGVSACKFDSITTGAIYSKLLKDERLGNYAGVTVQVIPHVTNIIKDFILSNTKGVDFIICEIGGTVGDIEGLPFFEAIRQIGNQLKSENCLFIHLTLLPYVKTARELKIKPTQHSVKALRAIGISPNILVCRAERNISKGEIDKISLLCNIESEYVVPAIDQKNIYLVPIAYHNSGLDNKVLKFFNINIMPSKLDKWHDIINRLKDSNSKVRIAIIAKYHKLKDAYKSVIEALDHAGIYYKYKIDLVWINAENLTEENINKKLLDIDGILVPGGFGERATKGKIIAIKYARTNNIPFFGICFGMQLATIEIAQNLIGIKDAVTEEFKVDGTKIIEKINKNCEDSKITIENVKKTMRLGSYPCSLVAGTIAANAYKSLEINERHRHRYKFNNEFQNIFEKHGIVFSGFSKDEEIVEIIELPLLRWFVGVQFHPEFKSKPFEAHPLFIQFIKAAIEYNKCN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: RPOA_CORGB
Sequence: MLISQRPTITEEFVDNARSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSVKIDGVLHEFTTISGVKEDVSDIILNIKGLVLSSDSDEPVVMQLVKEGPGVVTAGDIQPPAGVEIHNPDLHIATLNETAKIEIELIVERGRGYVPATVTATGGEIGRIPVDQIYSPVLKVSYKVEATRVEQRTDFDKLVIDVETKNSITARDALASAGKTLVELFGLARELNIAAEGIEIGPSPQETEYIAAYSMPIEDLDFSVRSYNCLKREDIHTVGELAERAESDLLDIRNFGQKSINEVKIKLAGLGLTLKDAPEDFDPSTLEGYDAETGGYIDVEAEDSE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RNFH_PSET1
Sequence: MIDVEVVFALPETATSLTIEVVKGTTVEQAVIQSGIIEKHPEIDATALTLGVWNRTVKPNQELKEGDRIEIYRPLIADPKDARRKRAEKAKEEGRANKVTGGRPIER
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: GULP1_HUMAN
Sequence: MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC
What is the function of this protein?
May function as an adapter protein.  Required for efficient phagocytosis of apoptotic cells.  Modulates cellular glycosphingolipid and cholesterol transport.  May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP.  Increases cellular levels of GTP-bound ARF6.
What are the official names of this protein?
PTB domain-containing engulfment adapter protein 1, Cell death protein 6 homolog, PTB domain adapter protein CED-6, Protein GULP.
What is the protein family that this protein belongs to?
Belongs to the ced-6 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.
Protein: RK2_EUCGG
Sequence: MAIHLYKTSTPSTRNGAVDSQVKSNTRNNLIYGQHRCSKGRNARGIITAGHRGGGHKRLYRKIDFRRNEKDIYGRIVSIEYDPNRNASICLIHYGDGEKRYILHPRGAIIGDTIVSGTEVPIKMGNALPLTDMPLGTAIHNIEITLGKGGQLARAAGAVAKLIAKEGKSATLKLPSGEVRLISKNCSATVGQVGNVEVNQKKLGRAGSKCWLGKRPVVRGVVMNPVDHPHGGGEGRAPIGRKKPATPWGYPALGRRSRKRKKYSDNLILRRRSK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL24_SYNS3
Sequence: MRLRKGDTVQVIAGKDKGKTGEVLRTLPNENRVIVEGLNMRTRHVKPTQEGETGRIVTEEASLHASNVMFYSTAKKVASRIELITEKDGSKKRRLKKTGEVID
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CD166_MOUSE
Sequence: MASKVSPSCRLVFCLLISAAVLRPGLGWYTVNSAYGDTIVMPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLSLSENYTLSIANAKISDEKRFVCMLVTEDNVFEAPTLVKVFKQPSKPEIVNKAPFLETDQLKKLGDCISRDSYPDGNITWYRNGKVLQPVEGEVAILFKKEIDPGTQLYTVTSSLEYKTTRSDIQMPFTCSVTYYGPSGQKTIYSEQEIFDIYYPTEQVTIQVLPPKNAIKEGDNITLQCLGNGNPPPEEFMFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKRNMAASTTITVHYLDLSLNPSGEVTKQIGDTLPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIHWTITGSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADDISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
What is the function of this protein?
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts.  Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity).  Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity).  Mediates homotypic interactions with cells that express ALCAM (PubMed:24740813).  Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction.  Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:23169771).  Required for normal organization of the lymph vessel network (PubMed:23169771).  Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813).  Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow (PubMed:25730656).  Promotes in vitro osteoblast proliferation and differentiation (PubMed:25730656).  Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity).  Mediates outgrowth and pathfinding for retinal ganglion cell axons (PubMed:15345243).
What are the official names of this protein?
CD166 antigen, Activated leukocyte cell adhesion molecule, BEN, Protein DM-GRASP.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen- presenting dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse.
Protein: ABHD5_HUMAN
Sequence: MAAEEEEVDSADTGERSGWLTGWLPTWCPTSISHLKEAEEKMLKCVPCTYKKEPVRISNGNKIWTLKFSHNISNKTPLVLLHGFGGGLGLWALNFGDLCTNRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWGFPERPDLADQDRPIPVWIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGKMHPDIPVSVIFGARSCIDGNSGTSIQSLRPHSYVKTIAILGAGHYVYADQPEEFNQKVKEICDTVD
What is the function of this protein?
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid (PubMed:18606822).  Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor.  Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity).  Functions in phosphatidic acid biosynthesis (PubMed:18606822).  May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289).  Involved in keratinocyte differentiation (PubMed:18832586).  Regulates lipid droplet fusion (By similarity).
What are the official names of this protein?
1-acylglycerol-3-phosphate O-acyltransferase ABHD5, Abhydrolase domain-containing protein 5, Lipid droplet-binding protein CGI-58.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Lipid droplet. Cytoplasm, cytosol. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity).
Protein: LATS2_HUMAN
Sequence: MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
What is the function of this protein?
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability.  Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.  Negative regulator of the androgen receptor.  Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities.  This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
What are the official names of this protein?
Serine/threonine-protein kinase LATS2, Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Warts-like kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.
Protein: PLRP3_BOVIN
Sequence: MVMSNLLLCQVNSCPSCCPDVFDIPLESLTHLFLNASRLSHDIVNHTTIMFHEFDEKYAQNQPYTINATKSCHTNSLHTPQEREKALRMNNEDLSKWILMLLYSWHRPLYLLVKDLQSMKEVSDTILSSAKENMRKIEELQAFIERQFSQVIYPVIRTIFKARIYWSGLASLVSNDEDVRHSAFYKLFMCLYRDSRKLDMYTEILACRITNTC
What is the function of this protein?
Placental prolactin-related proteins may play a specific role during gestation.
What are the official names of this protein?
Placental prolactin-related protein 3, PRC-III, bPRCIII.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROC_NOCSJ
Sequence: MLRWLTAGESHGPSLVAILEGLPAHVQVTSDDVADALARRRLGYGRGARMKFERDEVTLVGGIRHGETMGGPVAIEIGNTEWPKWEKVMAADPVDPVELESLARNAPLTRPRPGHADLVGMQKYDFTEARPILERASARETAARVALGRVASNLLEQAVGARIVSHVIELGGVRAPAGLWPQPEDVDRLDDDPVRCLDADTSKLMVEAIDQAHQDGDTLGGVVEVVVHGLPPGLGSHVHWDRRLDARLAGALMGIQAIKGVEVGDGFELAATPGSRAHDEIVSGTDGLRRVSGRSGGTEGGMSTGEVLRVRAAMKPIATVPRALRTVDVATGEAAVAHHQRSDVCAVPAAGIVAEAMVALVLADAVLEKFGGDSVRETRRNAEGYLDTLRFR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: GET3_ARTOC
Sequence: MSSTAIIGDDDVLEPTLQCLLDQKTLRWIFVGGKGGVGKTTTSCSLAIQLSKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGYDNLSAMEIDPNGSIQDLMASGGADGNDDAMGGFGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALSKLSQLSGQFGPMLNSVLGARGGLPGGQNLDDILSKMESLRETIAEVNSQFKDADMTTFVCVCIAEFLSLYETERMIQELTSYHIDTHCIVVNQLLFPGKDNACQQCGARRKMQKKYLNEIKDLYEDFNVVRMPLLVEEVRGREKLESFSDMLVHPFQPAHED
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: EF1D_BOVIN
Sequence: MATNFLMHEKIWFDKFKYDDAERKFYEQMNGPVAGSSRQENGASVILRDIARARENIQKSLAGSSGPGASSGPSGDHSELVTRIASLEVENQSLRGVVQDLQQAVSKLEARLSALEKSSPAHRATTPQTQHVSPMRQVEPPSRKAATATEDDEDDDIDLFGSDEEEDKEATRLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLEACVRSVQLDGLVWGSSKLVPVGYGIRKLQIQCVVEDDKVGTDQLEEEITKFEEHVQSVDIAAFNKI
What is the function of this protein?
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
What are the official names of this protein?
Elongation factor 1-delta, EF-1-delta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: MTDH_MESCR
Sequence: MANSAPENVHPQKAFGWAARDTSGTLSPLKFSRRATGEQDVTFKVLYCGICHSDLHYIKNEWGNAVYPAIPGHEIVGVVTEVGNKVQNFKVGDKVGVGCMVGSCRSCESCENHLENYCPKMILTYGSTYYDGTLTYGGYSDIMVVEEHFAVRIPDNMALDATAPLLCAGVTVYSPLKHFELDKPGLHIGVVGLGGLGHMAVKFGKAFGAKVTVISTSPNKKDEAVNRLGADSFVVSREPEQMQSAMGTLDGIIDTVSAAHPLLPLLGLLKSQGKMIMVGVPDKPLELPVFPLLQGRKILAGSCIGGMKETQEMIDFAAKHDIKSDIEVVPMDYVNTAMERLLKGDVRYRFVIDVANTLKAE
What is the function of this protein?
Oxidizes mannitol to mannose.  Provides the initial step by which translocated mannitol is committed to central metabolism and, by regulating mannitol pool size, is important in regulating salt tolerance at the cellular level (By similarity).
What are the official names of this protein?
Probable mannitol dehydrogenase, NAD-dependent mannitol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.