PharMolix/UniProtQA huggingface dataset:
Protein: HXA5_SALSA
Sequence: GRGRGQTYTRYQTLELEKEFHFNRYLTRRRRIEMAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGVGYHRP
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A5, S12-B.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NOP16_YEAS7
Sequence: MTSVRKRKMNRSSVGKATRRNKDKQRKINIQSNPIIAANWDYSLTMAQNYKKLGLRAKLQTPAGGKEADLSKVVKRIPLTKPVLDEDEDEDEGEDEQNDYNAATVELDENEIPEGEARIQRDKNGDVVRVVYGKKKNFDADEDVNKIKARDTTEETEVVKKLEELASRPVIRKERCQSEREEEWLEKLYKKHGDDYKKMFFDKKLNIYQQSEGDLKRRLLRWKKRNGIVSK
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Nucleolar protein 16.
What is the protein family that this protein belongs to?
Belongs to the NOP16 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HEMH_DROME
Sequence: MFLHNTKFCRLASGLAGGVRNLSGQKPKTAILMLNMGGPTHTDQVHDYLLRIMTDRDMIQLPVQSRLGPWIAQRRTPEVQKKYKEIGGGSPILKWTELQGQLMCEQLDRISPETAPHKHYVGFRYVNPLTENTLAEIEKDKPERVVLFSQYPQYSCATSGSSFNSIFTHYRSNNLPSDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRNDVVILFTAHSLPLKAVNRGDAYPSEIGASVHMVMQELGQTNPYSLAWQSKVGPLPWLAPATDDAIKGYVKQGLKNFILVPIAFVNEHIETLHELDIEYCDELAKEVGVEEIRRAATPNDHPLFIDALTNVVADHLKSQQAVNPKFLMRCPMCSNPKCRESKSWYRQLCSN
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX (PubMed:9712849).  Terminal enzyme in heme biosynthesis (PubMed:9712849).  Contains four conserved cysteines that function as cluster ligands and play a crucial role in maintaining protein structure (PubMed:9712849).
What are the official names of this protein?
Ferrochelatase, mitochondrial, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: TRXR_PLAF7
Sequence: MNNVISFIGNSSNKYFQINQLHFIRIINKNIHSKNNLINSNSSYNVFYNKYFIKNTFQNKNKLSSIYSKLNFSIKNMCKDKNEKKNYEHVNANEKNGYLASEKNELTKNKVEEHTYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKLMHYAGHMGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYINGLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDDIFSLKKDPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYMEEQGVMFKNGILPKKLTKMDDKILVEFSDKTSELYDTVLYAIGRKGDIDGLNLESLNMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIMDYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKDEYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGIHPTDAESFMNLFVTISSGLSYAAKGGCGGGKCG
What is the function of this protein?
Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins (PubMed:9368022, PubMed:11013257, PubMed:16910770, PubMed:23845423).  Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO (PubMed:11013257).  Has no catalytic activity towards oxidized glutathione (GSSG) (PubMed:11013257).
What are the official names of this protein?
Thioredoxin reductase, PfTrxR.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
[Isoform 1]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: RL32_KINRD
Sequence: MAVPKRKMSRSNTRSRRSQWKAAEETLVTSTVRGQVAYSRPHTARVVTDSAGTPLYLEYKGRKVKDL
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: Y557_BACC3
Sequence: MSIKYSNKINKIRTFALSLVFIGLFIAYLGVFFRENIIIMTTFMMVGFLAVIASTVVYFWIGMLSTKTVQIICPSCDKPTKMLGRVDACMHCNQPLTMDRDLEGKEFDEKYNKKSYKS
What are the official names of this protein?
UPF0295 protein BCA_0557.
What is the protein family that this protein belongs to?
Belongs to the UPF0295 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLDA1_ORYSJ
Sequence: MAQMLLHGTLHATIFEAASLSNPHRASGSAPKFIRKFVEGIEDTVGVGKGATKVYSTIDLEKARVGRTRMITNEPINPRWYESFHIYCAHMASNVIFTVKIDNPIGATNIGRAYLPVQELLNGEEIDRWLDICDNNREPVGESKIHVKLQYFDVSKDRNWARGVRSTKYPGVPYTFFSQRQGCKVTLYQDAHVPDNFIPKIPLADGKNYEPHRCWEDIFDAISNAQHLIYITGWSVYTEITLVRDSNRPKPGGDVTLGELLKKKASEGVRVLMLVWDDRTSVGLLKRDGLMATHDEETENYFHGSDVNCVLCPRNPDDSGSIVQDLSISTMFTHHQKIVVVDHELPNQGSQQRRIVSFVGGLDLCDGRYDTQYHSLFRTLDSTHHDDFHQPNFATASIKKGGPREPWHDIHSRLEGPIAWDVLYNFEQRWRKQGGKDLLLQLRDLSDTIIPPSPVMFPEDRETWNVQLFRSIDGGAAFGFPDTPEEAAKAGLVSGKDQIIDRSIQDAYIHAIRRAKNFIYIENQYFLGSSYAWKPEGIKPEDIGALHLIPKELALKVVSKIEAGERFTVYVVVPMWPEGVPESGSVQAILDWQRRTMEMMYTDITEALQAKGIEANPKDYLTFFCLGNREVKQAGEYQPEEQPEADTDYSRAQEARRFMIYVHTKMMIVDDEYIIIGSANINQRSMDGARDSEIAMGGYQPYHLATRQPARGQIHGFRMALWYEHLGMLDDVFQRPESLECVQKVNRIAEKYWDMYSSDDLQQDLPGHLLSYPIGVASDGVVTELPGMEYFPDTRARVLGAKSDYMPPILTS
What is the function of this protein?
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.  Plays an important role in various cellular processes.
What are the official names of this protein?
Phospholipase D alpha 1, PLD alpha 1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D 1.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. C2-PLD subfamily.
Protein: RL19_ROSS1
Sequence: MSQQIIEEIERRYMKQDVPEFDVGDTVRVGVRVVEGNRERVQEFEGVVIRKRGSGLNQNFTVRRIASHGIGVERTFLVHAPRVESIQVVRRGKVRRARLFYLRGLTGKAARIKERR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RPOA1_FRATW
Sequence: MSNNNSKLEFVPNIQLKEDLGAFSYKVQLSPVEKGMAHILGNSIRRVLLSSLSGASIIKVNIANVLHEYSTLEDVKEDVVEIVSNLKKVAIKLDTGIDRLDLELSVNKSGVVSAGDFKTTQGVEIINKDQPIATLTNQRAFSLTATVSVGRNVGILSAIPTELERVGDIAVDADFNPIKRVAFEVFDNGDSETLEVFVKTNGTIEPLAAVTKALEYFCEQISVFVSLRVPSNGKTGDVLIDSNIDPILLKPIDDLELTVRSSNCLRAENIKYLGDLVQYSESQLMKIPNLGKKSLNEIKQILIDNNLSLGVQIDNFRELVEGK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha 1, RNAP subunit alpha 1, RNA polymerase subunit alpha 1, Transcriptase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RL5_BURL3
Sequence: MARFQEFYKEKVVPGLIEKFGYKSVMEVPRITKITLNMGLGEAIADKKIIENAVGDLTKIAGQKPVVTKARKAIAGFKIRQGYPIGAMVTLRGQAMYEFLDRFVTVALPRVRDFRGVSGRAFDGRGNYNIGVKEQIIFPEIDYDKIDALRGLNISITTTAKTDDEAKALLASFKFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: CHO2_CANAL
Sequence: MTFTINNTNSTVFDSTNNENMTISEPVQPVSKGPKGITFSGETFIVPETHDMVKTLFDPTVKKSNFELIILSCLFSNLLVFLISNNQIRIYIFIALYIFWRLSYNFGIGWLLQNQSNHNLLVSWSQKYHLFDPENKGALAQSIQNEIKSQRGENYDIKSMPVEFNTWLIFRKFVDLILMSDFITFCCVVFCSAIKDDYQFINNQSSWLVYSRIVLGSGLILFNLWVKVNAHNTIKDYAWYWGDFFFRQINNEELIFDGVFEMVPHPMYSVGYVGYYGFALIAKSYVVLAIAIFGHFLQMIFLHYIENPHIDKIYGPSKNEINLIKILKLKDLKNFDNLKPLVGLTNFNWMRASDIVNLVLSLTYGIIIPLFANSIKSLFILTVGMKLFESISINLSLTLQSYFKIVTKWSLSNDIPVEKSFSNWAVLYNSLINLTYSSLFGMNLGYFLQKSGSDSPSSGLLFSDWFYLRVFLGLLLIYTQFWINFSIIDSIGYFGWFYGDFFIPKSQSSIKNITTAGVYRYLNNPEQIFGVCGVMGIFLIYPTVENFVCVGLWVVNNFIRINFIEKSHMVKLYGEQEVNRDSGVTKTVKKHLLPEVIQRRMSNDEAYTRINGTTHGRRRRSSNLHRNSVADSLDNFIRDLRNSSTKLSQQKLIELSQNLSFANSDYKLTIDGLKMQSTESDELKYTTIGTPVTVSWTSPTENHSVRDWIGLYKIVQTSYSRNKTILSSAGRWTWCKEPKGSFIFDKEKLFWEEGVYEFRYHLDGKHDVAYISEPFEIKSIELKVPEFKEDAIKFAENLKLEIFDKVIKLTDISEAISPIANQSDNVIEVYKLISSMISKSTKINITYKIFLNQGDDDLLSIKDVAIKLINIKHVLEELSYNITDKKDV
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ISPG_ACIC1
Sequence: MTTINLGVPEVPAKSPLAPRRKSRQINVGGVLVGGGAPISVQSMTTTLTADVNATLQQIAELTAAGCDIVRVACPSQDDADALPIIAKKSPIPVIADIHFQPKYVFAAIEAGCAGVRVNPGNIKKFDDKVKEIAQAAKDHGTPIRIGVNAGSLDPRILQKYGKPTAEALVESALWEASLFEEHDFHDIKISVKHHDPMVMVQAYRLLAAQTDYPLHLGVTEAGPLLQGTIKSAVAFGILLSEGIGDTIRVSLSAPPVEEVKVGIGILESLGLRPRKLDIVSCPSCGRAQVDVYKLAEEVQAGLQGFPFPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVRGEVIKTVPESQIVETLLEEAMRLAEEMQASGAFGDDQAVGAPIVTVQ
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: RHAR_ECO24
Sequence: MAHQLKLLKDDFFASDQQAVAVADRYPQDVFAEHTHDFCELVIVWRGNGLHVLNDRPYRITRGDLFYIHADDKHSYASVNDLVLQNIIYCPERLKLNLDWQGAIPGFSASAGQPHWRLGSVGMAQARQVIGQLEHESSQHVSFANEMAELLFGQLVMLLNRHRYTSDSLPPTSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQWRHLNSQKD
What is the function of this protein?
Activates expression of the rhaSR operon in response to L-rhamnose.
What are the official names of this protein?
HTH-type transcriptional activator RhaR, L-rhamnose operon transcriptional activator RhaR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_DAVTA
Sequence: MPISKIHSRYVYDSRGNPTVEVDIVTETGLHRAIVPSGASTGSHEACELRDGDKSKWAGKGVTKAVANVNEIIAPALIKENLDVKDQAAVDAFLNKLDGTTNKTKIGANAILGVSMAVAKAAAAEKRVPLYAHISDLSGTKKPFVLPVPFMNVVNGGSHAGGRLAFQEFMIVPSGAPSFTEAMRQGAEVYQKLKSLTKKRYGQSAGNVGDEGGVAPDIQTAEEALDLITDAIEEAGYTGQIKIAMDVASSEFYKADEKKYDLDFKNPDSDKSKWITYEQLADQYKQLAAKYPIVSIEDPFAEDDWEAWSYFYKTSGSDFQIVGDDLTVTNPEFIKKAIETKACNALLLKVNQIGTITEAINAAKDSFAAGWGVMVSHRSGETEDVTIADIVVGLRAGQIKTGAPARSERLAKLNQILRIEEELGDKAVYAGDNFRTAINL
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase, Allergen Cla h VI.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DB126_HYLLA
Sequence: MKSLLFTLAVFMLLAQLVSGNWYVKKCLNDVGICKKKCKPEELHVKNGRAMCGKQRDCCVPADKRANYPAFCVQTKTTRTSTVTATAATTTTLVMTTASMSSMAPTPVSPTS
What is the function of this protein?
Highly glycosylated atypical beta-defensin involved in several aspects of sperm function.  Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx.  Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation.  Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte.  In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (By similarity).
What are the official names of this protein?
Beta-defensin 126, Defensin, beta 126.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted by epididymal cells and is absorbed to the surface of sperm during transit through the epididymis.
Protein: MNMA_CORA7
Sequence: MRVLVAMSGGVDSSVAAARAVEAGHDVIGVHLALHKDAQQTREKARGCCSLEDSADARRICDKLGIPFYVWDFSEEFKEAVIGDFVDSYARGETPNPCLRCNEKIKFAALLRKGMALGFDAVATGHYATIDSDGYMRRSLDENKDQSYVLGVITKEELDHCFFPIGDTPKPQIREEAKRHGFSTAAKPDSYDICFIPDGNTQAFLGRSIGLRPGMIVDTEGNELKEHDGAWNYTIGQRKGLDIKTPTADGSPRYVTDIDAATGTVTVGSRADLAVTHIEADRLKYLHPAMEGDFDCEVQVRAHGSVVPCHAHVDREADRMTLELNEPLSGVARGQAAVLYLPSPDELGDIVLGSGTICGTE
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_ACIF2
Sequence: MTQTSHALFHMAQQCIPGGVNSPVRAFRGVGGDPIFIDHAEGPFFWDVEGKRYLDYVGSWGPMIHGHGHPEVLAAVHAQVNKGLGFGAPTAIEVEMAELVCALVPGIESVRMTSSGTEAVMTAIRLARGYTGRDRIIKFEGNYHGHSDSLLVKAGSGALTLGQPSSAGVPREVSQNTLVLPYNDLPAVVEMMAQFGFDVATIIVEPVAGNMGCVPPEPGFLEGLRAVCDQYGCVLIFDEVMTGFRVALGGAQALYGVRPDLTTLGKIIGGGLPVGAVGGPREIMEYLAPTGPVYQAGTLSGNPVAMAAGLATLRLLTVPGFHERLAAQTAVLCEGLAERAEAAGVPMQINHVPGMFGWFFAEQPVRGFDTVMAADSKRYARFFHGLLARGVYLAPSAYEAGFLSAAHGDTEIAATLDAAEAVLATLKEDA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_PSEPG
Sequence: MKAFTQHTGLVAPLDRANVDTDQIIPKQFLKSIKRTGFGPNLFDEWRYLDVGQPYQDNSKRPVNQEFVLNHARYQGASVLLARENFGCGSSREHAPWALDEYGFRSIIAPSFADIFFNNSFKNGLLPIILSDEEVDELFKQVEANPGYQLTIDLQAQAVTRPDGKVLHFEIDAFRKHCLLNGLDDIGLTLQDSDAIKAFEGKHRAGQPWLFRDA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: ADCY3_HUMAN
Sequence: MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS
What is the function of this protein?
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.  Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis.  Required for the perception of odorants.  Required for normal sperm motility and normal male fertility.  Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
What are the official names of this protein?
Adenylate cyclase type 3, ATP pyrophosphate-lyase 3, Adenylate cyclase type III, AC-III, Adenylate cyclase, olfactive type, Adenylyl cyclase 3, AC3.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus. Note=Also detected in the cytoplasm, close to lipid droplets.
Protein: KAD6_METJA
Sequence: MRIAITGTPGVGKTTISKVLRDRLGIKVIDITEAVKKYKLYTEKDEDMDSYVIDFEKLEKFIDEIEEKEKTIILDGHVSHLLNPDYIIVLRCNPEIIKERLEKRGYKPKKVLENIQAEILDVCLCESKGKVYEIDTTNRDVENIVDEIIEAIKHKKERKGVVDWTEKYFDYLTLEIK
What is the function of this protein?
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
What are the official names of this protein?
Putative adenylate kinase, AK, ATP-AMP transphosphorylase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK6 subfamily.
Protein: VIME_PANTR
Sequence: MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQDMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
What is the function of this protein?
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
What are the official names of this protein?
Vimentin.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Cell membrane.
Protein: HSL29_DICDI
Sequence: MTLFSSITSISKTNTSSKSSLNSFSGSSLSMGSNSVACGGCDKPAAGAAILANIDIKAKVDLSLSAAAAASAKCGACH
What are the official names of this protein?
HssA/B-like protein 29.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: PLDG1_ARATH
Sequence: MAYHPAYTETMSMGGGSSHGGGQQYVPFATSSGSLRVELLHGNLDIWVKEAKHLPNMDGFHNRLGGMLSGLGRKKVEGEKSSKITSDPYVTVSISGAVIGRTFVISNSENPVWMQHFDVPVAHSAAEVHFVVKDSDIIGSQIMGAVGIPTEQLCSGNRIEGLFPILNSSGKPCKQGAVLGLSIQYTPMERMRLYQMGVGSGNECVGVPGTYFPLRKGGRVTLYQDAHVDDGTLPSVHLDGGIQYRHGKCWEDMADAIRQARRLIYITGWSVFHPVRLVRRTNDPTEGTLGELLKVKSQEGVRVLVLVWDDPTSRSLLGFKTQGVMNTSDEETRRFFKHSSVQVLLCPRSGGKGHSFIKKSEVGTIYTHHQKTVIVDAEAAQNRRKIVAFVGGLDLCNGRFDTPKHPLFRTLKTLHKDDFHNPNFVTTADDGPREPWHDLHSKIDGPAAYDVLANFEERWMKASKPRGIGKLKSSSDDSLLRIDRIPDIVGLSEASSANDNDPESWHVQVFRSIDSSSVKGFPKDPKEATGRNLLCGKNILIDMSIHAAYVKAIRSAQHFIYIENQYFLGSSFNWDSNKDLGANNLIPMEIALKIANKIRAREKFAAYIVIPMWPEGAPTSNPIQRILYWQHKTMQMMYQTIYKALVEVGLDSQFEPQDFLNFFCLGTREVPVGTVSVYNSPRKPPQPNANANAAQVQALKSRRFMIYVHSKGMVVDDEFVLIGSANINQRSLEGTRDTEIAMGGYQPHYSWAMKGSRPHGQIFGYRMSLWAEHLGFLEQGFEEPENMECVRRVRQLSELNWRQYAAEEVTEMSGHLLKYPVQVDRTGKVSSLPGCETFPDLGGKIIGSFLALQENLTI
What is the function of this protein?
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA).  Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence (PubMed:10441386).  Can use phosphatidylserine (PS) and phosphatidylethanolamine (PE) as substrates only in the presence of PIP2.  Can use phosphatidylcholine (PC), phosphatidylglycerol (PG) or N-acylphosphatidylethanolamine (NAPE) as substrates in the presence of PE and PIP2 (PubMed:9578608, PubMed:17098468).  Involved in membrane lipid modulation under aluminum (Al) stress and negatively modulate plant tolerance to Al (PubMed:22163277).
What are the official names of this protein?
Phospholipase D gamma 1, AtPLDgamma1, PLD gamma 1, Choline phosphatase, Lecithinase D, Lipophosphodiesterase II.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. C2-PLD subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Found mainly associated with intracellular membranes but also with mitochondrial membranes, nuclei and clathrin-coated vesicles. Not found in chloroplast.
Protein: YACG_YERPP
Sequence: MESEQIQVNCPTCGKVVIWGEQSPFRPFCCKRCQLIDLGEWADEEKRIPSDTELSDSDEWSEEDPLKH
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: RLME_TREDE
Sequence: MAKNKYSEPDYWSKKAFAENYPARSVYKLEEMNKKFNLFSPNDKVLDLGAAPGSWTVYVLRFLNKEGRVTAVDLKPLDSSVYDERLNFFQGDMFDKGIIKSVKELGPYDAVICDAAPATTGNKTVDTARSSGLVELALYYAQEQLKQGGSFVVKIFQGGDQQIHLNNLRKCFKTARAFKPEACRSSSFETYLIGLDFKG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAA_ECODH
Sequence: MKYDTSELCDIYQEDVNVVEPLFSNFGGRASFGGQIITVKCFEDNGLLYDLLEQNGRGRVLVVDGGGSVRRALVDAELARLAVQNEWEGLVIYGAVRQVDDLEELDIGIQAMAAIPVGAAGEGIGESDVRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPRD_BOVIN
Sequence: MMSPLHSSWRTGLLLLLLFSVAVRESWQTEEKTCDLVGEKGKESEKELALLKRLTPLFNKSFESTVGQSPDMYSYVFRVCREAGNHSSGAGLVQINKSNGKETVVGRFNETQIFNGSNWIMLIYKGGDEYDNHCGREQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTLASLVAVYIIGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
What is the function of this protein?
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.  Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
What are the official names of this protein?
Cation-dependent mannose-6-phosphate receptor, CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46.