PharMolix/UniProtQA huggingface dataset:
Protein: RL30_PSEME
Sequence: ANTVKVTLIKSTNGRLANHKAXVK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: UBP36_MOUSE
Sequence: MPIVDKLKEALKPGRKDSAEDGDLGRLLAASAKKVLLQRIEFEPASKSFSYQLESLKSKYVLLSARAEGASRHRSGDELQARKPGTERVSGSGGDGVPAPQKVLFPVERLSLRWERVFRVGAGLHNLGNTCFLNSTIQCLTYTPPLANYLLSKEHARSCHQGGFCMLCLMQNHMVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGYAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDIALEIRQAANIVRALELFVKSDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQSSGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGPVSRVGATLPSRPKVVPEHSKKSPGNGVVPSPLMAKRQDSVMMRKLPAPEEVGVPVSRNGSLPGLKLQNGCAPAKTPAGSPSPRLTPTPTHMPTILDEPGKKVKKSAPLQSLTTSPTTSQGSPGTGESRSQRPGSWASRDTIFSTSPKLLARAITNGHRLKGEGSGVDLEKGDSSSSSPEHSASSDPAKAPQTAESRAAHACDSQGTNCPTAGHPKALLNGVDAKMVKLKSPALSSTTTEPTSLMSPPPAKKLALSAKKASTLRRATGNDIGSPSPSAFCDLTSPMKATHPVVASTGPVSKTRTAAPAPRPSTHPHSASLSSSSAKPLGTSEPQSCRPSAWTPLPQVNGHFTSHLHQLPEASEALHSPSKKRKKTPNGDPQRLGIDTLLPQCLRGAPAAARRKRKKRCSEGEGATAPKQEGQFQDQSWSSGSQKEEGTQPQVNGHQVSHILDSYHVSSRKRRKRKRSEGLSQEATPSQDLIQHSCSPVDHSEPEARTELQKKKKKKRRKRKPEPQQDEESKHPGDQRSPRPSVTPVPALSVNGHLPSDCLGLGQAPLVTWNRDQEPDVVQALLQDSSDKAYGKKVLTWDGEPSAISQDAIKDSRLARTQTVVDDWDEEFDRGKEKKIKKFKREKKRNFNAFQKLQSRRNFWSVTHPAKVASLSYRR
What is the function of this protein?
Deubiquitinase essential for the regulation of nucleolar structure and function.  Required for cell and organism viability (PubMed:29273634).  Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634).  Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).  Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (By similarity).  In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (By similarity).  Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (By similarity).  Deubiquitinates SOD2, regulates SOD2 protein stability (By similarity).  Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (By similarity).  Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 36, Deubiquitinating enzyme 36, Ubiquitin thioesterase 36, Ubiquitin-specific-processing protease 36.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm.
Protein: FMT_FRATT
Sequence: MKKLNIIFAGTPDISAQVLKDLYKSQHNIQAVLTQPDRAKGRGKKVQFSPVKEVALANHTPVFQPLSFKKNPEVLEQIKQLKPDVIVVIAYGIIVPQEFLDIPRYGCLNIHVSLLPKWRGAAPIQRAIQAGDTKTGVCIMQMDAGLDTGDILNTLEIEIQETDTSQTLHDKFAKLSIKPLLETLEKIEIIKPEPQQGEPTYAHKITKQEGLIDFTKSAWQISCHIRAFTPWPGAYFILDDEAIKVGEFEILYQNTDNRKAGTIIDIYRSGFDIATSDKIIRFRQLQFPNKKMLNIVDILNGKDLDKYIGYKLG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: PLCG2_HUMAN
Sequence: MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSNSKFYS
What is the function of this protein?
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.  It is a crucial enzyme in transmembrane signaling.
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, Phosphoinositide phospholipase C-gamma-2, Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2.
Protein: ADRB1_MACMU
Sequence: MGAGALVLGASEPGNLSSAAPLPDGVATAARLLVPASPPASLLPPASEGPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPSPSPVPAPPPGPPRPAAAAATTAPLVNGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRNAFQRLLCCARRAARRRHAAHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATQPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  This receptor binds epinephrine and norepinephrine with approximately equal affinity.  Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity).  Involved in the regulation of sleep/wake behaviors (By similarity).
What are the official names of this protein?
Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity).
Protein: RHCG_XENTR
Sequence: MRLRLPVVCFLWEIAMIVLFGIFVRYNDEADPHWSEFMKAQNITSDIQNDYYFRYPSFQDVHVMIFVGFGFLMTFLKRYGFGSVAFNFLLAAFGIQWAILMQGWFHTFKNGKILIGVESLINADFCVGSVCIAFGAILGKVSPVQIMVMTLFQVTLFAVNEWILLNLLHVNDAGGSMTIHTFGAYFGLTVAWILNRPRLKQTNDKEGSVYVSDLFSMIGTLFLWMFWPSFNSAVSYHGDAQHRAAINTYCSLAACVLTTVAISSVVNKKGKLEMVHIQNATLAGGVAVGTAAEMMLTPYGSLIVGFICGIVSTLGFTYCSPFLSNKLRLHDTCGIHNLHAMPGLIGGIVGAVTAACATEAVYTADGLKKMFRFEGDYATRTPSMQGGYQAAGLCVSLAFGLVGGTVVGCILKLPIWGDPSDENCFDDEVYWELPEEDEEEHLGAANQYVTHLPENFKLPDRTEVAFK
What is the function of this protein?
Functions as an ammonia transporter.
What are the official names of this protein?
Ammonium transporter Rh type C, Rhesus blood group family type C glycoprotein, Rh family type C glycoprotein, Rh type C glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: SOSB2_BOVIN
Sequence: MNGVRDPPLFIKDIKPGLKNLNVVFIVLEIGRVTKTKDGHEVRSCKVADKTGSITISVWDEIGGLIQPGDIIRLTRGYASMWKGCLTLYTGRGGELQKIGEFCMVYSELPNFSEPNPDYRGQQNKGAHNEQKNNSMNNSNNVGTGTFGPMGNGVQTGAEARGCQFSYAGRSNGRGPINPQLPGTANNQTVMTTISNGRDPRRAFKR
What is the function of this protein?
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint.  In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines.  The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability.  Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity).
What are the official names of this protein?
SOSS complex subunit B2, Nucleic acid-binding protein 1, Oligonucleotide/oligosaccharide-binding fold-containing protein 2A, Sensor of single-strand DNA complex subunit B2, Sensor of ssDNA subunit B2, SOSS-B2, Single-stranded DNA-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the SOSS-B family. SOSS-B2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to nuclear foci following DNA damage.
Protein: LPLT_YERPA
Sequence: MSQDVLADKPLLSRSMVAVLCAQFFSAFGDNALLFATLALIKQQLYPDWSQPILQMAFVATYIVLAPFVGQIADGFAKGRVMMVANGLKLAGALVICFGLNPFLGYSLVGVGAAAYSPAKYGILGEITSGEQLVKANGMMEASTIAAILLGSVAGGILADWHLMAALGVCALVYAIAVIANLFIPRLAAARSGASWRPRAMTGSFFTACRLLWQDSETRFSLAGTSLFWGAGVTLRFLLVLWVPVALGIADNATPTLLNAMVAIGIVVGAGAAARFVTLKTVKRCLPAGVLIGVMVTIFSLQNSMPMAYLLLIIIGILGGFFVVPLNALLQERGKHSVGAGNAIAVQNLGENTAMLFMLGLYSLVVKLGAPVVAVGVGFGVVFALAIALLWGWQWRQQRQKTRQPE
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDH_STAEQ
Sequence: MAQDRKKVLVLGAGYAGLQTVTKLQKELSADAAEITLINKNEYHYESTWLHEASAGTINYEDLLYPVEKTVNKDKVNFVVAEVTKIDRNAKRVETDKGVYDFDILVVALGFVSETFGIDGMKEHAFQIENVLTSRKLSRHIEDKFANYAASKEKDDKDLSILVGGAGFTGIEFLGELTDRIPELCSKYGVDQSKVKLTCVEAAPKMLPMFSDDLVSYAVKYLEDRGVEFKIATPIVACNEKGFVVEVNGEKQQLEAGTSVWTAGVRGSHLMEESFEGVKRGRVINKQDLTIEGHNDIFVIGDCSAFIPAGEERPLPTTAQIAMQQGEHTASNIKRLLNGESTQDFQYVNRGTVCSLGANDGVGIVYGRDIAGKKAAFLKKVIDTRAIYKLGGIGLAFKKGKF
What is the function of this protein?
Alternative, nonproton pumping NADH:quinone oxidoreductase that delivers electrons to the respiratory chain by oxidation of NADH and reduction of quinones, and contributes to the regeneration of NAD(+).
What are the official names of this protein?
Type II NADH:quinone oxidoreductase, NDH-2.
What is the protein family that this protein belongs to?
Belongs to the NADH dehydrogenase family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: MTSB_STREE
Sequence: MITEFIDGLQQFHFLQNALITAIAIGIVAGAVGCFIILRGMSLMGDAISHAVLPGVALSFILGINFFIGAIAFGLLASILITYIKSNSIIKSDTAMGYLSLPRPRSHSDRVAKSSTDLFHILFGNILAVQDQDMWVTIGVGVAVLLVIVLLFRPLLLTSFDPVLAQSMGVRVKLYHYLLMVLLTLVSVTAMQSVGTILIAAMLITPAATAYLYANSLWSMMLLSSGLGALASILGLFIGYSFNIAVGSCIVLTSAIFFLISFFIAPKQRKNKHALSPH
What is the function of this protein?
Part of an ABC transporter complex involved in manganese import.
What are the official names of this protein?
Manganese import system permease protein ScaB, ORF1.
What is the protein family that this protein belongs to?
Belongs to the ABC-3 integral membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: U518_DROPE
Sequence: MSWLRSSPLRQSGNGGGGGVSTGHSSTGSLRQRPIDAATDCDPRACYDSFCKHWQQAYDIIQHYAPPTHDDVLGVVSHLDYMVTLLLVELHHCNKVSLPSTDASAAPAAPCLEYLLSENLLDKLYEWACTTGRYANAVRLEQLKLYELLVSHSRHQLLCHEPFLRPLLKILASSQGEIFPPDLEKRLVILLNQLCVVLMQNVHLLDLFFFSAQTQVQEQIQNGNVPPPKSGTTTNFIIFSLLIPYVHREGSLGHQARDALLLCMALSQKNSNIGTYIAQYSSICPLLVTGLGGLYSRLPNSIEISSIDWHRITPDDVTEIPELTLFMNALEFCNAVVQVAHEMIKQQLLDFMYQGFIVPVLGPAVLQTLKGKHFQTNIDSQISAMSYLDLILRSITEPGLLRAFVKFLLDTEKFDGERILDSLVERLNSPDANLCMVTMALFDTLLGLHCEDLMLELLLKFMLPGKHVPISHRHKINKIDPYLNSSDFFLELSPDVLKRARDLARPKSVHEQQPPSGATGEQPIQPLAWPSLPSPVMSKTIGANWNYYGLHTGDSLYANLQAYLFEAHWRIAQCQRDCLKWANSYRYQKWPRHGQARVHAHALELARQFFSEFGGGPPAIASESAGEKQLDSLQSIGESSGYESFKWRPADEESDATDLTVTTTTTTASEADLEHNSSSISSGMGGGGGAAAGRRGEAWRISHTNRNELLLTDLDFSEDLFAQGTVSLGPFLNAIWGKLQTFTSNSLYVNLHLTGLITRLAWYPLPLIHSLLLRSDIAITSDTPSFHQVLRILKQQIDAELPVTEDSLEIIDVARSSLIDREFRLVNARKGNENSPLHHHQQPQTTLSQQQQQQQGQQRSAYATLSAATPVQATQTSAYDPFKRSDNKRKSISKSISSMFSRRSTPNPPSSAGAASTLVGNNNSGSGQSQPFSSTGTGTCETSLSTNPQSGAAAARSTGTATTANGNSSNSNISIGGSTQTLSGHSNTTTYSSSTLHGLDGGPQTGSFNSEPASLDSVASMGIIASTSGTERTRDVALCAVLLDEWLKELAAIAQEQSVVLVTDQLL
What are the official names of this protein?
FHIP family protein GL19323.
What is the protein family that this protein belongs to?
Belongs to the FHIP family.
Protein: CXG1_XENTR
Sequence: MSWSFLTRLLEEINNHSTFVGKVWLTVLIIFRIVLTAVGGESIYYDEQSKFTCNTQQPGCENVCYDAFAPLSHVRFWVFQIILITTPSIMYLGFAMHRIARQPEMQIRRSEKTKSKKRAPIIHRGAMRDYEEAEDNQEEDPMICEEEEPEKDSEKGDKKKHDGRRRIKQDGLMKVYVLQLLFRSVFEVGFLMGQYILYGFEVIPFFVCSRKPCPHTVDCFVSRPTEKTIFLLIMYAVSALCLFLNLCELFHLGIGGIRDALRQKKKELQESRKKTPSAPPNYHSVLKKGRLPNGKPVFPGNGVSEGFELPTHELDRLRQHLKLAQEHLDLAFHLNPTGDNTHASRSSSPESNSIAAEQNRLNLAQEKGVGNREKSGL
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction gamma-1 protein, Gap junction alpha-7 protein.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Gamma-type subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: PANB_PARXL
Sequence: MTYLQEASRNAVTVPKLQAMRDAGEKIAMLTCYDASFAALLDRAGVDVLLIGDSLGNVLQGQTTTLPVSLADIAYHTASVARARPAALIVADLPFGTYGTPEDAFRSSVELMRAGAQMVKLEGGEWLADTVRFLVERSIPVCAHVGLTPQSVHAFGGFKVQGKTEAGATQLLRDSLAVQAAGAQLIVMEAIPTLLASDATKQLRIPTIGIGAGLDCSGQVLVLHDMLGIFPGKRPRFVKDFMQGQPSILAAVEAYVAAVKDGSFPGPEHTF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_MESHJ
Sequence: MKNIVDDKILLTQQKLEEIEKELEHLINVERVNVIQEIKDARSQGDLSENAEYDVAREKQGIIESRIRELETIISKAKIIKADLGSSRVSIGSKVSLENVESGEIQTFQIVSSIDADPFKSKISNFSPIAQALLGQHQGDEVEVDVNEKYSVRILEVINE
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: TRMD_NITEU
Sequence: MPFEFDVITLLPDMFDAVTQHGVTGRAHKSNLYRLHTWNPRNYAMNHYRTVDDSPYGGGPGMVMMAEPLDKAITDAKARQGEDGVSKTRVIYLSPQGKRLDHKKVLQISQLDGVVLLCGRYEGIDERLIEDQVDEEISIGDYVISGGELAAMVLIDAVVRQLPGALGDTRSAGQDSHTDHLLEYPHYTRPEVHKEKPVPRILLSGDHAKIERWRLQQSIGRTWLKRPDLLAEKYPEGLPDREKELLEEFKQLRYRVVANQLMDNTKEQEQ
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_SHIFL
Sequence: MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKAELESAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDATRLLRTQTSGVQIRTMKAQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVSIDPEVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_PROMM
Sequence: MADFLAPKSNTHATISSRFQRVQAEGRLALMPFLMAGDPDLETTAEVLLSLEQSGADMIELGIPYSDPLADGPVIQAAASRALASGTTPARVLQMLIDLRGKLSIPVILFTYTNPLFNRGMERFCDEAAEAGVAGLVVPDLPLEEAERLSPLASARGLDLVLLVAPTTPAERMARIAESSRGFTYLVSVTGVTGERSVMEDRVQSLVQQLKLSGSNPVAVGFGISGPQQVRQVRSWGADGAIVGSALVKRMAAAAPGLVAQEAGLFCKELRNAAG
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: HXD1_HUMAN
Sequence: MSSYLEYVSCSSSGGVGGDVLSLAPKFCRSDARPVALQPAFPLGNGDGAFVSCLPLAAARPSPSPPAAPARPSVPPPAAPQYAQCTLEGAYEPGAAPAAAAGGADYGFLGSGPAYDFPGVLGRAADDGGSHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFPACLKASADGHPGAFQTASPAPGTYPKSVSPASGLPAAFSTFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLHLNDTQVKIWFQNRRMKQKKREREGLLATAIPVAPLQLPLSGTTPTKFIKNPGSPSQSQEPS
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Acts on the anterior body structures.
What are the official names of this protein?
Homeobox protein Hox-D1, Homeobox protein Hox-GG.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Labial subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNLJ_ACTP2
Sequence: MPLLSQMQEYQADTTFAQLEALRQKLREYEYHYHVLDNPLVPDAEYDRLMNELKNLEWQHPEWITVDSPTQRVGAKPLDGFAQVTHEIPMLSLDNAFSDEELDGFLRRMESYITEDPHTLAFCCEPKLDGLAVSILYVDGVLSQAATRGDGSTGEDITSNIRTIRNIPLKLNMDNPPARLEVRGEVFMPQKGFEELNERALEKGEKTFANPRNAAAGSLRQLDPKITRQRPLVLNAYGIGVYESDDELPATHFERLQWLKSIGIPVNNEIRLATGREQLLAFYANIQAKRPTLGYDIDGTVLKVNDIGLQEQLGFISRSPRWAIAYKFPSQEEMTVLNDVEFQVGRTGAITPVAKLEPVFVAGVTVSNATLHNGDEIERLGIVIGDTVIIRRAGDVIPQIVGVVMDRRPENAKKIEFPTACPVCESAVVRVEGEAVARCTGGLFCGAQRKEALKHFVSRKAMDIDGVGEKLIEQLMERELVHTPADLFKLDHTTLMRLERMGEKSAQNALNSIEKAKNTTLARFLFALGIRDVGEATAQNLANHFHNLAAIRTATFEQLQAVQDVGEVVANRIVRFWQEPHNVAVVEDLISQGVHWQDVIQVEIADNPLKGKNVVLTGTLTQLTRDQAKALLQSFGCKVSGSVSSKTDYLIAGEKAGSKLAKAQELGVKILTEQEFIALTGEN
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: C1GLT_RAT
Sequence: MASKSWLNFLTFLCGSAIGFFLCSQLLNILLQEQADVQPNMLHNDPHARHSDDSGHNHLKGQMDFNADSSQHKDENTDVAENLYQKVKVLCWVMTSPQNLEKKAKHVKATWAQRCNKVLFMSSEENKDFPTVGLETKEGREQLYWKTIKAFQYVHDHYLEDADWFMKADDDTYVILDNLRWLLSKYNPEQPIYFGRRFKPYVKQGYMSGGAGYVLSKEALRRFVDAFKTEKCTHSSSIEDLALGRCMEIIKVEAGDSRDPTGKETFHPFVPEHHLIKGYLPKTFWYWNYNYYPPVEGPGCCSDIAVSFHYVDSTTMYELEYLVYHLRPYGYLYRYQPALPENILKEINQVNKKEDTKIKLGNP
What is the function of this protein?
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.  Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.
What are the official names of this protein?
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, Core 1 O-glycan T-synthase, Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1, Core 1 beta1,3-galactosyltransferase 1, C1GalT1, Core 1 beta3-Gal-T1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
What are the subcellular locations of this protein?
Membrane; Single- pass type II membrane protein.
Protein: BABA2_CHLAE
Sequence: MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDVEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.  The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.  May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins.  May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.  May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
What are the official names of this protein?
BRISC and BRCA1-A complex member 2, BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, Brain and reproductive organ-expressed protein.
What is the protein family that this protein belongs to?
Belongs to the BABAM2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).