PharMolix/UniProtQA huggingface dataset:
Protein: RL1_LEGPH
Sequence: MSKLTKKQKKIAEVIKPNQLYTVADAVAILKQFASKKFRESLDISINLGVDPRKSDQVVRSSTNLPKGTGKTVRVAVFAQGDNAAKATAAGADIVGFEDLADKIKAGEMNFDVVIATPDAMRIVGQLGQILGPRGLMPNPKVGTVTTNVEAAVNDAKSGQVRYRTDKNGIIHCTVGKADFAPEDVLENVVALINDLKKAKPASSKGQYLKKISLSTTMGPGLPIDISSIPV
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: HEM6_SHEB5
Sequence: MSVPDAAVVKAFLLDLQNRICAGLQALDGQARFAADSWTRAEGGGGTSRVLTQGAVFEQAGVNFSHVTGAAMPASATAHRPELAGRSFEAMGVSLVIHPNNPYIPTTHANVRFFIAQKEGADPVWWFGGGFDLTPYYPFEEDVREWHQTSKDICAPFGDEVYPKYKKWCDEYFFLPHRNETRGVGGLFFDDLNQAGFEQSFSFMQAVGNGFLTAYAPIVERRKDTEFGERERQFQLYRRGRYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYTPEAGSPEADLYDNYLKPRDWV
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_SYNS3
Sequence: MAAVSLSVSTVKPLGDRVFVKISESEEKTAGGILLPDTAKEKPQVGEVVQVGPGKSNDDGSRQAPEVGIGDKVLYSKYAGTDIKLGSDEYVLLSEKDILAVVG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HLDE_ECODH
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: TIM14_BOVIN
Sequence: MASTVVAVGLTIAAAGFAGRYALQAMKHMEPQVKQVFQSLPKTAFSGGYYRGGFEPKMTKREAALILGVSPTANKAKIRDAHRRIMLLNHPDKGGSPYIAAKINEAKDLLEGQAKK
What is the function of this protein?
Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity).  May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM14, DnaJ homolog subfamily C member 19.
What is the protein family that this protein belongs to?
Belongs to the TIM14 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: RISB_CAMJD
Sequence: MNIIEGKLNLDSNTKIAIINARFNHIITDRLVEGAKDAFLRHGGKKENLSLILVPGAFELPYALKKAIESEKFDAICCVGAVIRGSTPHFDYVSAETTKGIANVSLNHNIPVSFGVLTTDTIEQAIERAGSKAGNKGFEAMTTVIEMLNLTKEL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: AZOR_METSB
Sequence: MKLLHIDSSILGDHSVSRQLTAAIIARLQEVTPDLDVSHRDLAANPLSHLSGALLAASAPGAPAPDPSTQAALGESAAILAEFLAADIVVVGAPMYNFAISSQLKAWIDRLVIAGKTFRYADGAVEGLAGGRRLIIASSRGGVFEAGAAAAALDYQETYLRAIFGFIGIADVEIIRAEGLAFGEDARALAIKQAGDAILRLEAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: Y1134_NOSS1
Sequence: MSLEDRAKATGKNIEGKAQEALGNVTGDPEDKAEGKAKQAESEVRHGVEDVKDNVKKKID
What are the official names of this protein?
UPF0337 protein asr1134.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: PIB2_YEAST
Sequence: MTALHSVSKTPAIKEEEEDGDERDGRGVPLGPRNHDYRGRKGDEESGADTVTSPITFEKKKIAPRASTHSEQSILSSISLKSMVNQHRQQQLQQESSTGAGTGFVDRKQQIQSPAMVSILRKNSAEENVRSSHSSKLGEGQIDGRKASASKEIGKTLPFTDDQRSNPELDPTNSVVDVSRGKNTKSKTVFNELEDDADDDDEVRQKNLTTQALRKLSSFKMNASSNLRLSKENKAKESSSSSTSSVSSSSTSKVENIVDKLTTTNSSSMSQLRFGNTNVIIDSVNHAAKPPHQQMLRKPSLEFLPQPASSTNLNFNSNKHKSNVRQISNPKKPLYIPAVLRKVSETNITNDDLLNATLSSYYKKASNLEHGFNPSKSQSASVQNANNLRIISSQSSVQSNTSSILESYKNKISSYLFPNSIPNSDRINLIPTISNRNSARVNPPTKDHWIPDSKRNSCRYCHKPFTLWERKHHCRHCGDIFCQDHLRHWLYLDSQANFIMINELNNGGINGGGTLCKICDDCLVEYENLSTTNHNANTNEDNINVEEGEDDDNDNRKKLRNYYKNRQMNALFRPKKGGSSQEHATVDRDTTTPIQVKSNDEEADNENTGGEQEEGNDVLGSVIGSVPANWNWSSF
What is the function of this protein?
Functions as an intracellular glutamine sensor that directly activates the TORC1 signaling pathway, to promote cell growth when glutamine is available (PubMed:34535752, PubMed:29698392, PubMed:28483912, PubMed:26510498, PubMed:32801125).  May play a role in repressing NPR1 activity independently of TORC1 signaling (PubMed:28993463).
What are the official names of this protein?
Glutamine sensor PIB2, Phosphatidylinositol 3-phosphate-binding protein 2.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein.
Protein: RS19_ERWT9
Sequence: MPRSLKKGPFIDLHLLKKVEKALESGDKKPLRTWSRRSTIFPNMIGLTIAVHNGRQHVPVFVSDEMVGHKLGEFAPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: NUCL_PONAB
Sequence: MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEEDDSEEDEDDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDEDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDDDDDDEDDEDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE
What is the function of this protein?
Nucleolin is the major nucleolar protein of growing eukaryotic cells.  It is found associated with intranucleolar chromatin and pre-ribosomal particles.  It induces chromatin decondensation by binding to histone H1.  It is thought to play a role in pre-rRNA transcription and ribosome assembly.  May play a role in the process of transcriptional elongation.  Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
What are the official names of this protein?
Nucleolin.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: RIBB_METMA
Sequence: MSENMAYECLKYSNENINRALEALRAGKMIQIYDSDSREGETDLVIPAKAVTYTDVKWMRKDAGGLICVAVDPVASKQLKLPFMADLVREASKTSDSLGEVVEKDGDLKYDAHSSFSLWVNHRDTRTGIPDIERALTIRKIGEITEESLSGNGVRFGNEFRTPGHVALLRAAEGLLDERMGQTELSVALARMAGITPAMVVCEMLDDDSGKALSKEKSKEYGKEHGLVFLEGREIVEAYLLWAGTDC
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: RS2_PHOPR
Sequence: MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNDALAEINKIAARKGKVLFVGTKRAASESVKESAISCDQYYVNNRWLGGMLTNWKTVRQSIKRLKELEIQSADGTFEKLTKKEALMRTREMEKLEKSLGGIKNMGGLPDAMFVIDADHEHIAIKEANNLGIPVFSIVDTNSNPDGVDFVIPGNDDAIRSIQLYTGAVAQTVTEARNQDIVVQAEQDGFVAEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RL29_CUPTR
Sequence: MKASELRGKDAAGLNQELSELLKAQFSLRMQKATQQLQNTSQLKKVRKDIARVQTVLTEKANAK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: RS2_RHOE4
Sequence: MAVVTMKQMLDSGTHFGHQTRRWNPKMKRFILTDRNGIYIIDLQQTLTYIDKAYEFVKETVAHGGTVLFVGTKKQAQESIASEATRVGMPYVNQRWLGGMLTNFTTVHKRLLRLKELEAMEQTGGFEGRTKKEILMLTREMTKLDRTLGGIRDMAKVPSAVWIVDTNKEHLAVAEARKLNIPVIAILDTNCDPDLVDYPIPGNDDAIRSAALLTKVVASAVAEGVQARAGLSADKDAKPEAGAGEPLAEWEQELLSQAAPAAEAEAAPAAEAEAAPAAEAPATEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: MEIG1_NEMVE
Sequence: MTAVAQKCGPKSVSRPKHWSEEVEEAYRFQCAGYRDAIEYSDIKQKEPERWPHNGYVKKLQRKDGCFVYFDKTRECQDKDVNKTKMYGY
What are the official names of this protein?
Meiosis expressed gene 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the MEIG1 family.
Protein: AMPA_SYNE7
Sequence: MTFQAIATHPQDWTGDTLALGLTTAAIGETLSSELQKLDQQWNGVLQELISDSEFKAKLAETTTTRIGGSIRKLILVGLGESPTTEDYRRAAAAVAKQARSFKSQTLAIAFPPSDDPAAIASAIVEGISLALYKDQRFKSEPDTASGPSSIELLGLAGQEAAIARAEQVVAGVELARQLVAAPANVVTPVTMADTAQELAAELGLELEILEADECEKRGMGAFLGVAKASDLPPKFIHLTYRPESTPRRKLAIVGKGLTFDSGGYNIKGAGSGIEMMKTDMGGAAATLGAAKAIGLIKPDVEVHFISAVTENMISGRGMHPGDILTASNGKTIEVNNTDAEGRLTLADALVFADGLGVDAIVDLATLTGACIIALGDDIAGLWSPSDDLAEQLLQAGKAAGEKLWRLPLEEPYLDGLKSPVADYKNTGPRAGGSITAALFLKQFVKHPVWAHLDVAGPVWSDKEKHYNPAGATGYGVRTLVNWVLS
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LETM1_MOUSE
Sequence: MASILLRSCRGRGPARLAPPRAASPRGSLRDRACLSCTRTLGLTSRESVLSRCCTPAHPVYLCFKGEPLSCWTQRPECQGTAARTTWTPASARLVVTGPQYLPVRGWHSSSPLGEDSVIEKSLKSLKDKNKKLEEGGPVYSPPAQVVVRKSLGQKVLDELRHYYHGFRLLWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNMLPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATKDFSAFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEEGVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLHHEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEKVDNKAKLEATLQEEAAIQQEHLEELKRASEAVKDIQPEVAEATLPGRPGPEPQPPVDDVILPSEVLTDTAPVLEGLKGEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYIEESAASKRLSKRVQQMIGQIDGLITQLETTQQDGKLGPSQSTPTGESVISITELISAMKQIKHIPEHKLISLTSALDDNKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATLEKEEKIEEKEKAKEKAEKEAAEVKN
What is the function of this protein?
Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:27669901, PubMed:23716663).  Mediates proton-dependent calcium efflux from mitochondrion (PubMed:27669901, PubMed:23716663).  Functions also as an electroneutral mitochondrial proton/potassium exchanger (By similarity).  Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity).  Required for the maintenance of the tubular shape and cristae organization (By similarity).  Essential for early embryonic development (PubMed:23716663).
What are the official names of this protein?
Mitochondrial proton/calcium exchanger protein, Electroneutral mitochondrial K(+)/H(+)exchanger, KHE, Leucine zipper-EF-hand-containing transmembrane protein 1.
What is the protein family that this protein belongs to?
Belongs to the LETM1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: ADS3_ARATH
Sequence: MASLLTKPKPVFLCSPSLSPRTLNTATPSLNFTRISFTHHQKLAPFKPPSLVVAFSEKGLKRDVTTAAAATEGDYRRIMLSDVLVKKKEKVVWWEREWKAMDFGAVAVVLSMHLLSLLAPFQFNWRAVSVAFGLYIVTGLLGITLSFHRNLSHKAFKLPKWLEYLFAYCGAQALQGNPIDWVSTHRYHHQFCDSDRDPHSPLDGFWFSHMNWMFDTNTITQRCGEPNNVGDLEKQPFYRFLRTTYILHPLALAVALYAMGGFPFIVWGMGVRIVWVYHITWLVNSACHVWGKQAWNTGDLSKNNWWVAALAFGEGWHNNHHAFEFSARHGLEWWQLDMTWYVVKFLQAIGLATDVKLPSEAQKQRMAFTSD
What is the function of this protein?
Fatty acid desaturase involved in the first desaturation step leading to the formation of hexadeca 7,10,13-trienoic acid (16:3(7Z,10Z,13Z)), the major functional components of thylakoid membranes (PubMed:15579662, PubMed:16666902, PubMed:15240892).  Required for chloroplast biogenesis at low temperature (PubMed:16668849).  Also indirectly involved in the production of the oxylipin dinor-oxo-phyto-dienoic acid implicated in wound signaling (PubMed:15579662).
What are the official names of this protein?
Palmitoyl-monogalactosyldiacylglycerol delta-7 desaturase, chloroplastic, Acyl-lipid desaturase 3, Fatty acid desaturase 5, FAD5, Fatty acid desaturase B, FADB, Monogalactosyldiacylglycerol-specific palmitic acid desaturase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: INT2_MYCTO
Sequence: MTQTGKRQRRKFGRIRQFNSGRWQASYTGPDGRVYIAPKTFNAKIDAEAWLTDRRREIDRQLWSPASGQEDRPGAPFGEYAEGWLKQRGIKDRTRAHYRKLLDNHILATFADTDLRDITPAAVRRWYATTAVGTPTMRAHSYSLLRAIMQTALADDLIDSNPCRISGASTARRVHKIRPATLDELETITKAMPDPYQAFVLMAAWLAMRYGELTELRRKDIDLHGEVARVRRAVVRVGEGFKVTTPKSDAGVRDISIPPHLIPAIEDHLHKHVNPGRESLLFPSVNDPNRHLAPSALYRMFYKARKAAGRPDLRVHDLRHSGAVLAASTGATLAELMQRLGHSTAGAALRYQHAAKGRDREIAALLSKLAENQEM
What is the function of this protein?
Integrase is necessary for integration of the phage into the host genome by site-specific recombination.  In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity).
What are the official names of this protein?
Putative prophage phiRv2 integrase.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: CEMA_NUPAD
Sequence: MTKKKALNPLPYLASIVFLPWGISLSFNKSMEPWVTNWWNTSQSETFLNDIQEKNILEGFIKLEELFLLDEMIKEYPETHIQKLRIGIHKETIQLVRMHNQDHIHIILHFSTNITCFAILSAYSILGNEELIALNSWVQEFLYNLSDTIKAFSILLLTDLCIGFHSPHAWELMIGSFYKDFGFVQNDKIISGLVSTFPVILDTILKYWIFHYLNRVSPSLVVIYHSLNE
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: ICP0_HHV11
Sequence: MEPRPGASTRRPEGRPQREPAPDVWVFPCDRDLPDSSDSEAETEVGGRGDADHHDDDSASEADSTDTELFETGLLGPQGVDGGAVSGGSPPREEDPGSCGGAPPREDGGSDEGDVCAVCTDEIAPHLRCDTFPCMHRFCIPCMKTWMQLRNTCPLCNAKLVYLIVGVTPSGSFSTIPIVNDPQTRMEAEEAVRAGTAVDFIWTGNQRFAPRYLTLGGHTVRALSPTHPEPTTDEDDDDLDDADYVPPAPRRTPRAPPRRGAAAPPVTGGASHAAPQPAAARTAPPSAPIGPHGSSNTNTTTNSSGGGGSRQSRAAAPRGASGPSGGVGVGVGVVEAEAGRPRGRTGPLVNRPAPLANNRDPIVISDSPPASPHRPPAAPMPGSAPRPGPPASAAASGPARPRAAVAPCVRAPPPGPGPRAPAPGAEPAARPADARRVPQSHSSLAQAANQEQSLCRARATVARGSGGPGVEGGHGPSRGAAPSGAAPLPSAASVEQEAAVRPRKRRGSGQENPSPQSTRPPLAPAGAKRAATHPPSDSGPGGRGQGGPGTPLTSSAASASSSSASSSSAPTPAGAASSAAGAASSSASASSGGAVGALGGRQEETSLGPRAASGPRGPRKCARKTRHAETSGAVPAGGLTRYLPISGVSSVVALSPYVNKTITGDCLPILDMETGNIGAYVVLVDQTGNMATRLRAAVPGWSRRTLLPETAGNHVMPPEYPTAPASEWNSLWMTPVGNMLFDQGTLVGALDFRSLRSRHPWSGEQGASTRDEGKQ
What is the function of this protein?
SUMO-targeted ubiquitin ligase that plays an essential role in nuclear antiviral defense evasion triggered by dsDNA viruses (PubMed:32001251).  Acts during the initial stages of lytic infection and the reactivation of latent viral genome.  Prevents the antiviral effect of nuclear bodies by degrading host PML, SP100 and MORC3 (PubMed:27440897, PubMed:34759314).  Prevents antiviral response to viral DNA induced by IFI16 by degrading it.  Additionally, inhibits host IRF3 nuclear signaling to prevent interferon production by the infected cells.  Interestingly, the E3 ubiquitin ligase activity associated with the RING finger domain does not seem to be directly required to inhibit the activation of IRF3 but instead plays a critical role in modulating the cellular localization of ICP0.  Upon reactivation of latent genome, suppresses the silencing of viral DNA by dissociating either HDAC1 or HDAC2 from the HDAC-RCOR1-REST-KDM1A complex localized at the ND10 structures and causes their dispersal.  Two cellular histone ubiquitin ligases RNF8 and RNF168 are also targeted by ICP0 for degradation, leading to a loss of ubiquitinated forms of H2A, a relief of transcriptional repression, and the activation of latent viral genomes.  Enhances the localization of host CCND3 to ND10 bodies that serve as precursors of replication compartments to enable efficient viral replication.  Like many RING-finger E3 ubiquitin ligases, ICP0 can induce its own ubiquitination, an activity that promotes its instability due to its targeting to the 26S proteasome for degradation.  ICP0 restricts this process by recruiting the cellular ubiquitin-specific protease USP7 that cleaves the anchored ubiquitin chains from ICP0, thereby promoting its stabilization.
What are the official names of this protein?
E3 ubiquitin-protein ligase ICP0, Alpha-0 protein, Immediate-early protein IE110, RING-type E3 ubiquitin transferase ICP0, Trans-acting transcriptional protein ICP0, VMW110.
What is the protein family that this protein belongs to?
Belongs to the simplexviruses ICp0 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: SPEE_PROM2
Sequence: MTNITTWIDEYHKGSRFGLNGKILIKKTSKYQEIILIENEYYGKALMLDGCWMTSLKDEKYYHECLVHPALSSIEEKSNILIIGGGDGGTVRECVKYSQISKIDLVEIDEEVIKISKKFLKEIGGEAWNDKRLEIHVDDGVKWVKKTRDNFYDVIFIDSSDPSEFSNLLFSDSFYKECKRILTPSGILATQSESPESFKNIHINILKTLKNIFKSSETMYSFVPIYPSGIWSWTFASSKNLNLSKQNYDEVKKIEKGCEIWNLNFQNAAFKMMPNKIVKELDS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1949_LEGPC
Sequence: MLTWALIFFIIAIIAAAFGFGGIAVAAAGIAKILFFLFLVMFVIFLIMGLLGRRGPPPV
What are the official names of this protein?
UPF0391 membrane protein LPC_1949.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS15_META1
Sequence: MVSKQKIEELVKKFGRNAKDTGHLPVQIAILTEKIESLKKHFEANKKDLHSMRGFIAKVNHRKALLSHLKSSNYELYLETIKALNIRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: FCGR2_CAVPO
Sequence: MAIPSFLPVLGTKSHRADYKPLQTLSHMLLWITVLFLAPVAGTSADPPKAVVRLEPPWIQVLRGDRVTLTCEGAPSPGNHSTQWLHNGRLIPTQVLPSYRFTAKGNDSGEYRCQAGGTSLSDPVRLDVISDWLVLQTSQLIFQEGDVIVLRCHSWNNWPLAKVTFYHNGVAKKYFSISKNFSIPQANHSHSGAYNCTGLIGRTSHTSPPVTITVQGPKSSDSSMVVIIVAAVIGIATAAIVVAVVAIICLKKKQPPGNPEHREMGETLPEDPGEYSVVFGGSMMSCPGLPDGLEPARTDLSNLSDPEEVAKSEVENTITYSLLKHPEAQDDDTEHDYQNHI
What is the function of this protein?
Binds to the Fc region of immunoglobulins gamma.  Low affinity receptor.
What are the official names of this protein?
Low affinity immunoglobulin gamma Fc region receptor II, IgG Fc receptor II, Fc-gamma RII, FcRII, Fc-gamma-1/gamma-2 receptor.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PXR1_YEAST
Sequence: MGLAATRTKQRFGLDPRNTAWSNDTSRFGHQFLEKFGWKPGMGLGLSPMNSNTSHIKVSIKDDNVGLGAKLKRKDKKDEFDNGECAGLDVFQRILGRLNGKESKISEELDTQRKQKIIDGKWGIHFVKGEVLASTWDPKTHKLRNYSNAKKRKREGDDSEDEDDDDKEDKDSDKKKHKKHKKHKKDKKKDKKDKKEHKKHKKEEKRLKKEKRAEKTKETKKTSKLKSSESASNIPDAVNTRLSVRSKWIKQKRAALMDSKALNEIFMITND
What is the function of this protein?
Involved in rRNA-processing at A0, A1 and A2 sites through its action in U18 and U24 snoRNA 3'-end final trimming.  Negative regulator of telomerase through competition for binding to EST2 with TLC1.
What are the official names of this protein?
Protein PXR1, G-patch nucleolar protein, PinX1-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the PINX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HFQ_SHEB8
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQVESFDQFVILLKNTVSQMVYKHAISTVVPARPFNVTGHQNAQGGYGAQDDAPSGE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.