PharMolix/UniProtQA huggingface dataset:
Protein: EFG_LACJO
Sequence: MANKREFPLDKTRNIGIMAHIDAGKTTTTERILYYTGKIHKIGETHEGDSQMDWMEEEKERGITITSAATTAQWKDYRINIIDTPGHVDFTIEVERSLRVLDGAVTVLDAQAGVEPQTENVWRQAETYGVPRIVFVNKMDKIGADFDKSVKSLHERLNANAQAVQMPIGSADTFEGVIDLINMVADVYDEDKLGSKWDTIPVPDEYKEEALKRRNELIEAVADVDDGIMDKYLGGEEISNDELKAAIRKATLNLEFFPVYAGSAFKNKGVQMMLDGVVDYLPSPLDVKPYVAHDPKTGDEVELMADDKKPFAALAFKIATDPFVGRLTFIRVYTGSLQSGSYVLNASKNSRERVGRLLQMHANSRTEISEVFSGDIAGAIGLKNTTTGDSLTDPAHPLILESLQVPDPVIQVSVEPKSKADRDKMDVALQKLTEEDPTFRAETNPETGQTLISGMGELHLDIMVERMKREFNVEATIGEPQVAYRETFTKEAKAQGKFVRQSGGKGQYGDVWIEFTPNEEGKGYEFEDAIVGGVVPREFIPSVDQGLQEAMKNGVLAGYPLIDVKAKLYDGSYHEVDSSEAAFKVAASLALRNAASKAGAVILEPIMKVQVTTPEEYLGDVMGSITARRGSMEGMEDRAGAKVINSFVPLSEMFGYATTLRSSTQGRGTFTMVFDHYSPTPKSIQADIIKKRGGEDAE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_CHLTA
Sequence: MAKKSAVAREVKRRKLVEANFQKRAELRKLAKSLSVSEEERERAREALNKMRRDTSPSRLHNRCLLTGRPRGYLRKFAISRICFRQMASMGDIPGVVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: Y1462_CROS8
Sequence: MTETPFWQRKTLDEMSDAEWESLCDGCGQCCLHKLMDEDTDEIYFTNVACRQLNIKTCQCRNYERRFEYEPDCIKLTRENLPTFEWLPPTCAYRLLAEGKNLPLWHPLRTGSKAAMHAERISVRHIAVKESEVRDWQDHILNKPDWAE
What are the official names of this protein?
UPF0260 protein ESA_01462.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: HIS4_NEIMF
Sequence: MLLIPAIDLKEGRCVRLRQGLMEEATVFSDSPAETALHWFEQGARRLHLVDLNGAFAGVPQNLPAIKDILAAVAKDIPVQLGGGIRDLKTIGQYLDLGLNDVIIGTAAVKNPDFVREACKAFPGRIIVGLDAKDGMAAIDGWATVTGHHVIDLAKRFEDDGVNSIIYTDIGRDGMMSGVNIDATVKLAQAVRIPVIASGGLTGLDDIRALCAAEKHGVAGAITGRAIYEGSIDFAQAQQLADSLD
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_HELPS
Sequence: MKIGVFDSGVGGFSVLKSLLKAQLFDEIIYYGDSARVPYGTKDPTTIKQFGLEALDFFKPHKIELLIVACNTASALALEEMQKHSKIPIVGVIGPSILAIKQQVKDKNAPILVLGTKATIQSNAYDNALKQQGYLNVSHLATSLFVPLIEENILEGELLETCMRYYFTPLEILPEVVILGCTHFPLIAHQIEGYFMEHFALSTPPLLIHSGDAIVEYLQQKYALKKNACAFPKVEFHASGDVVWLEKQAKEWLKL
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: ATPA_BUCAP
Sequence: MQLNSTEISQLIKERIAQFEVFNQSYNEGTIISVNDGIIKIYGLSDVMLGEMILLPDNEYAIALNIERDTIGAVVMGPYIHITEGTKVRCTGKILEVPVGVALLGRIVNALGFPIDGKGSIEHDIYLPVEADAPGVIERESINEPIQTGYKAIDAMVPIGRGQRELIIGDRQTGKTALAIDTIINQKKINLPCVYVAIGQKLSTIINVVKKLDEHDALLNTIVVVASASEAASLQYLAPYSGCAMGEYFRDRGKDALIVYDDLSKHAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERASRVSKEHVKNVTKGKITGKTGSLTALPIIETQSGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNAGISVSRVGSAAQTKIIKKLSSGIRTALAQYHELAAFSQFASDLDQTTRKQLIYGQKITELLKQKQYRPMSISEQGLMFFIAENNFLDDISVENIIQFEKEILTYAYNYHLDLMEEINKDGNFNDIIKKKFIELINNFKNS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RUVC_VIBCH
Sequence: MSVILGIDPGSRVTGYGVIRQQGRHLIYLGSGCIRTSDLELPLRLKQIYAGVSEIITQFQPDAFAIEQVFMAKNADSALKLGQARGSAIVAAVNAELPVYEYAARLIKQAVVGTGAADKSQVQHMVQQMLKLPGKPQADAADALGVAICHANTNKTLIALAGQATSARRGRYR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: STK31_MOUSE
Sequence: MWGQRLFAGTAVAQSVSFPGLVQMDEDTHYNKVEDVVGSHVEDAVTFWAQNVSKNKDIMKIGCSLSEVCPLANSVFGNLDPKKIYGGLFSEDKCWYRCKVLKTISDDKCLVRYIDYGNTEILNRSDIVEIPPELQFSSIAKKYRLWGLQIPSGQEVTQFDQGRTFLGSLIFEKEIKMRIKATYQDGTVIAQAEYGTVDIGEEVAKKGFAEKCRLTSGIDACEAKKPDPNQLALRSLKNPIPLWGRRSNQSTFSRPKGHFNGRLTLDVKYETSAGNHVTFPKESLAAGDFNLGSNVSLAKIKQDQKLIEENEKLKTEKEVLLENYKALELKVEQTAQELQQEKTATMDLTKHLESTLKTCVGTRLKNLAAKVELLKEIRHINISIRFGNDLSDAMQVLDEGSFTTLASLNELEKIWAEYNVAQEKIQTCLNENEGNILIAERNEVQQKLFVAVDVFILEVDDLPLDKRLKTLQDLATSLESVYGKAKEGTNNSEETLRKFYDWQCTKREEFASIRSETEASLQHLVAWFQSSQKVFDLSLDEPLTSEDLIGNIDEILEKTESCVCKELELSLIEQGVIDKEIILSTYSQVLQKIHSEEKFIATLLSKYKDSVEFKKQMIDCLNKNPNVDYLLSIKKTLKGLKAQLRWKLVEKSNLEESDDHDGTEIEKIKQEITQLRNSVFQEIYHEREEYEKLNSLTQKWFPELPLLYPEIGLLKYMNSGGLLTMSLERDLLDTEPMKELSSKRPLVCSEVNGQPVLLKGYSVDVDTEGRVIQRAASYHRACGYAKEESGLLPLIFLFLCKSDPVAYLMVPYYPKANLSAVQASMPLTSEEALKVMKGVARGLHTLHSANIIHGSLHQNNVFALNREQGIVGDYDFTKSESQRASVNAMVGGLSLLSPELKTGKPPSASSDLYAYGCLFLWLSVQNQEFETNEDGIPKVDQFHLDDNVKSLLCSLIYFRSSMTAEQVLNAECFLLPKGKSVPIPEKEIECTQHSREDESKMESLDRYSEKTRNGEANP
What are the official names of this protein?
Serine/threonine-protein kinase 31.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: YGD3_SCHPO
Sequence: MTETVTTTSSDKSEKKNYLFYTSPNHRPPTVVRAEGVYLYLEDGTRIMDATGGAAVACLGHGNKEVIDAMHKQSEKVCYIHSMGFSNEPADKLANLLVSEHPDVFARAYFANSGSEAVETCLKLILQYWQLVGEKQRCHIIARKQGYHGNTLFALSVGGMKPRKQPYEGVFSHTTSHVSPCFEYRYKENGETTEEYVARLAKELEDEILRVGPEKVAAFVAETVSGACTGCATPVPGYFKAMRKVCDKYGVIFYLDEVMSGIGRTGTMHAWEQEGVTPDIQSIAKCLGGGYQPISGALVGHRIMNVFEQKDAAMAGFFTYQAHPIACSAALAVQTILRRDHLVERAAEMGKYLSEKLHETFDSHPNVGNIRGRGLFWGLEIVKDKATKECFPPEYKVGSLANKIGCEHGVFVYPGMGTIDGTRGDHVLLAPPYIITREQIDELVEALSKTITSTVAALP
What are the official names of this protein?
Uncharacterized aminotransferase C1771.03c.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASIP_LEORO
Sequence: MDVTXLLLATLLVFLCCFAAYSHLPPEEKLRDDRSLRSNSSVNLLDLPSVSIVALNKKSKKISRKEAENKRSSKKEASKQKVARPRTPLSVPCVSTRGSCKPPAPACCHPCASCQCRFFRSACSCRVINVNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: YRAN_ECO57
Sequence: MATVPTRSGSPRQLTTKQTGDAWEVQARRWLEGKGLRFVAANVNERGGEIDLIMREGRTTVFVEVRYRRSALYGGAAASVTRSKQHKLLQTARLWLARHNGSFDTVDCRFDVVAFTGNEVEWIKDTFNDHS
What are the official names of this protein?
UPF0102 protein YraN.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: HIS5_BUCMH
Sequence: MSVVIINTGCSNLSSIKYAICRLGYNPKISTSVRDILSANKILLPGVGSAYSAIRVLSESNLLNIIKKCQQPFLGICLGMQLLSAFSSEAQGLDLLSIINSPVYRLNSGSLPLPHNGWNNVEICRNNVLFEDIENHSKFYFLHSYSVDITKYTIAKTLYNTYFSAAIQKNNFW
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_PSELT
Sequence: MKITDQLIPTVIESTGRYERAYDIYSRLLKDRIVFLGYAIDDHVANLVVAQLLFLEAEDPDKDIQLYINSPGGSVTAGLAIYDTMQYIKSDVVTICVGQAASMAAVLLASGTKGKRFALPNARIMLHQPLGGAEGPVKDVEIITKELLRIKNLINTILSEKTGQPLDRIEKDTDRDFFMSAYEALDYGLVDKVIESKRR
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OST4_DROME
Sequence: MITDVQLAIFSNVLGVFLFLLVVAYHYINANTGKPSAKAK
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the OST4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: RS21_SHIDS
Sequence: MPVIKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTTERKRAKASAVKRHAKKLARENARRTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RL11_FRAP2
Sequence: MAKKKIEAIIKLQVAAGKANPSPPIGPALGQHGVNIMGFCKEFNAKTQGMEPGMPIPVEISVYSDRSFTFEMKTPPASYLIKKAIKVKSGSSNPSKDFIGTITREQLEEIAKVKDPDLTAADIDAAVRIIAGSARSMGVKVEGVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: M3E_CONAO
Sequence: DCCIIAGCPFGCTICC
What are the official names of this protein?
Conotoxin ar3e.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CTRB1_MOUSE
Sequence: MAFLWLVSCFALVGATFGCGVPAIQPVLTGLSRIVNGEDAIPGSWPWQVSLQDRTGFHFCGGSLISENWVVTAAHCGVKTTDVVVAGEFDQGSDEENVQVLKIAQVFKNPKFNSFTVRNDITLLKLATPAQFSETVSAVCLPTVDDDFPAGTLCATTGWGKTKYNALKTPDKLQQAALPIVSEAKCKESWGSKITDVMICAGASGVSSCMGDSGGPLVCQKDGVWTLAGIVSWGSGFCSTSTPAVYARVTALMPWVQEILEAN
What are the official names of this protein?
Chymotrypsinogen B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: PIMT_METJA
Sequence: MDLEEQKKAVIEKLIREGYIKSKRVIDALLKVPREEFLPEHLKEYAYVDTPLEIGYGQTISAIHMVGMMCELLDLKPGMKVLEIGTGCGYHAAVTAEIVGEDGLVVSIERIPELAEKAERTLRKLGYDNVIVIVGDGTLGYEPLAPYDRIYTTAAGPKIPEPLIRQLKDGGKLLMPVGRYLQRLVLAEKRGDEIIIKDCGPVAFVPLVGKEGFQG
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins (By similarity).
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_VIBCM
Sequence: MTTIVSVRRNNKVVIAGDGQVSLGNTVMKGNARKVRRLYNNKVLAGFAGGTADAFTLFERFESKLQMHQGHLTKAAVELAKDWRSDRALRRLEAILAVADETASLIITGNGDVLQPEHDLIAIGSGGNYAQAAAIALLENTELDARTIAEKALNIAGDICVFTNHHHTIEELEIPQAMLPQGASA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TB22B_MACFA
Sequence: MAADNSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVGTVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKCSWPGVPREVRPVTWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR
What is the function of this protein?
May act as a GTPase-activating protein for Rab family protein(s).
What are the official names of this protein?
TBC1 domain family member 22B.
Protein: TOM7_BOVIN
Sequence: MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFKRGADPGMPEPTVLSLLWG
What is the function of this protein?
Required for assembly and stability of the TOM complex (By similarity).  Positive regulator of PRKN translocation to damaged mitochondria.  Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity).
What are the official names of this protein?
Mitochondrial import receptor subunit TOM7 homolog, Translocase of outer membrane 7 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the Tom7 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: SYS_ERYLH
Sequence: MHDIRQIRDNPEAFDAALARRGHEPVAAEILALDEQCRAVTTKMQEAQSRRNEASKAIGQAMGQGNTEKAEALKAEVADLKQTLPRLEDEDRELKMRLENALAVIPNLPLDDVPDGADESDNIEVGTWGTKREFSFEPREHADIGPALGMDFETGARLSGARFTFLRGGMARLHRALGQFMLDRQVSEYGYAECAPPVLVRDEAMYGTDKLPKFAEDSFQTTDGRWLIPTAEVSLTASVMDQILDDAALPMRLTALTPCFRSEAGAAGKDTRGFIRQHQFEKCELVSIVRPENSAAEHERMTEAAESVLQALDLPYRKMLLCTGDMGFGARKTYDLEVWLPGQGAYREISSCSNTGDFQARRMNARYRPEGEKKTAFVHTLNGSGLAVGRTLVAVIENYQEEDGSVAVPEVLAPYMGGAMKLEPTP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_SYNAS
Sequence: MKRDDLVSPECMDGDNVYETTLRPHSIKEYVGQKKIKKTLPIFVEAAQKRKEALDHVLLYGPPGLGKTTLALIIAREMGFNIKVTSGPVIERPGDLAAILTNLKDYDILFIDEIHRLPHSVEEILYPAMEDFYIDIVIGQGPSARSMKLDIPKFTLVGATTRAGLLTSPLRDRFGISFRLDYYAVEELTKIINRSASIMSIEIEHSGALEIAKRSRGTPRIANRLLKRVRDYAQVKGEGIIKRAVAVHALEMLEIDDRGFDQMDRSILLSIIENYGGGPVGIDTLCATVGEEKTTIEDVYEPYLIKEGYLQKTARGRIATKKAYEHFGKRKFEVGQKELF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PSBC_AETGR
Sequence: MKTLYSLRRFYHVETLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGIGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGVGAFLLVLKALYFGGVYDTWAPGGGDVRKITNLTLSPSVIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICIFGGIWHILTKPFAWARRALVWSGEAYLSYSLAALSVCGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLSTSHFVLGFFLFVGHLWHAGRARAAAAGFEKGIDRDFEPVLSMTPLN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MUTL_EXIS2
Sequence: MGIIRELSDSLANRIAAGEVVERPASVVKELVENALDAGATQVDVELEEAGMKRITIRDNGHGFYPEDAELAFVRHATSKIKDEHDLFRIKTLGFRGEALASIASVSKVTLKTKREEQEGIQLTLDCGRLTDRSAIAMNRGTELTVEQLFFNTPARLKYLKTTHTELAAITDILNRVAFAHPDVKLYAVHEGKVLIQTNGSGDVRQALASVYGHQTIQGTLVATGTTADYQLTCHLVKPEVTRASKNYITLILNGRSVKNFALTQAVLNGYHTLLPIGRFPIAVIEVTMDPLLIDVNVHPAKREVRLSKEAELCQLIQETIRLTLSRQTLIPKVTPQKPKKDPSAQEKLEFSYVAEPVEELSSRSVWNYPIPKRTEAGNEHVPSANRIQPPDPSIDMPDEPVPEQTDEPVATGPKFPHLDVIGQLHSSYIVCSGADGMYLIDQHAAQERIKYETYKVMFGRPLEQKQQLLLPYTFEIASDDMRRMDEVLPLLRDVGIELEAFGPQSFIVREVPTWFPSHRQEETIQELMDEALMKRKVDLETYREDAAIMMACKKSIKANHPLNHEMMRQLIVDLAKTEMPFTCPHGRPVIIEWTTYELEKLFKRVT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: SMKY_MOUSE
Sequence: MPAHIEEELPPPSPQPSNPEDGELYSQYKVVRTLGHGTYAKVLLAKHWLTGTPVAVKVLLKNKPCFQPAMKEANIMKKIKHPNIVSLLQVFETKTRGYLIMELVEGQELYEYIKSSGHIEEDEARQIFLQILSAVSYCHGLGIVHRDLKPDNIMIDDKGSIKIIDFGLSTQVKPGDLLDEHCGAYAFGAPELFLWKSYDGTKSDLWALGVILYYMVVGKVPFDSYIIPELQRQILAGVYPAPCGVSNELKDLLSLLMTVNPKYRPTVTEVMKHPWLRGHCKGLTNIHEEPVPVRPDPDIVDAMQYIGFQAKDIRESLTKEKFNEMSAAYYLLEEQALQREVRSTQAPTVSQVKAPFPSMDAGEASCLKIKRSGSASILGRSVWPPSIDQEPAYVQKVRQRAGRRSSGHGLLFEANQMTPTQDQHHIRAMSVPCMLSTSSISEESVSEKREENLSHIALAEDKPIRSRGWCRGIMRWTRRVGNAIRTLCCCIPSRKTPQLGQSRVSPQK
What is the function of this protein?
May play a role in sperm motility, especially in the regulation of flagellar function.
What are the official names of this protein?
Sperm motility kinase Y.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily.
Protein: M3K19_HUMAN
Sequence: MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLVNEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQCLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPEEENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNKAASKRVSLHKNEAMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKISIAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKHKMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQELEELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERSH
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 19, Regulated in COPD, protein kinase, SPS1/STE20-related protein kinase YSK4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Protein: RL4_THETH
Sequence: MKEVAVYQIPVLSPSGRRELAADLPAEINPHLLWEVVRWQLAKRRRGTASTKTRGEVAYSGRKIWPQKHTGRARHGDIGAPIFVGGGVVFGPKPRDYSYTLPKKVRKKGLAMAVADRAREGKLLLVEAFAGVERQDQAIPAWAKEAGLDGSESVLLVTGNELVRRAARNLPWVVTLAPEGLNVYDIVRTERLVMDLDAWEVFQNRIGGEA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.