PharMolix/UniProtQA huggingface dataset:
Protein: ZNTR_HAEIN
Sequence: MKIGALAKALGCTVETIRYYEQQGLIPPPKRTSGNFRQYNEEHLQRLSFICNCRNLDISLSEIKSLLNLENASKQQAEEINRVLDKHIKEVATRIHELAHLRMKLIELREKTVSNDEDPMKLLLQHSGVKFVRLK
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
HTH-type transcriptional regulator ZntR homolog.
Protein: CAMP_BOTLT
Sequence: MQGFFWKTLLVVALCGTSSSLAHRPLSYGEALELALSVYNSKAGEESLFRLLEAVPQPEWDPLSEGSQQLNFTIKETVCQVEEERPLEECGFQEDGVVLECTGYYFFGETPPVVVLTCVPVGGVEEEEEDEEEQKAEVEKDEEKEDEEKDRPKRVKRFKKFFKKLKNNVKKRVKKFFRKPRVIGVTIPF
What is the function of this protein?
Potent antimicrobial peptide against Gram-negative and Gram-positive bacteria.  Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane.  Low hemolytic activities have been observed on mammalian cells.
What are the official names of this protein?
Lutzicidin, Cathelicidin-related antimicrobial peptide, CRAMP, Vipericidin.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: PELC_EMENI
Sequence: MKKYLLSLLAAVTYTTAQSVSGSAEGFASGVTGGGGATPVYPADTAELESLLSSEGEQVIVLTKTYDFTGTSATGTACYSWGTGEGCQLILQDDCGDTPSTTVTYDAAGKTPIPVASDKTLLGVGSEGVIKGKGLSFTDNVSNIIVQNIKITELNPEYVWGGDALTFDGSSNICIDHVETSLIGRVHYVFGYNPNSGITLSNNFINGETTYSTSCDGYQYWGLELVGKNDSITFKGNYLYKTSGRSPALSGSTKFHACNNVWSDNNGHAIEGNEKGQGLFEGNVFQEVATVVSSTFWEAGDLFLSSADGTGNDACASYIGRNCASSIYMNDGGDYTSYTDVSWLGDWSGLTIAECAEAREIEGTVPTSAGNTL
What is the function of this protein?
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins (By similarity).
What are the official names of this protein?
Probable pectin lyase C, PLC.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MSL7_ARATH
Sequence: MEFRKPFKSHSSYKQIISTGDQNEKTKKKKKLANLDDGDIAKTQSSGSSFDGNSYKFWQDIATDDYTKSGSFDFPQYREEITLDVNEETEETEDVSNNNNLSGSKETRVFFKINSSGTNNMSGSVRSCTSSTSFSSATMRLNLEQQLEDEGEVVVRCSSVRKTELVSRAKARSRLIDPPQEEEQQYSSWIGTSDQLRSGLLGRHSDDIEEEDDSSAEEDVPVEYRKLKMDAITLLQWMSLIALVVALVLSLGLHTWRNATLWSLHLWKWEVVLLVLICGRLVSGCGIRIIVFFIERNFLLRKRVLYFVYGVKTAVQNCLWLGLVLLAWHFLFDKKVEKETQSDVLLLMSKILVCFLLSTVLWLIKTLVVKVLASSFHVSTYFDRIQEALFHHYLIETLSGPPMLELSRIEEEEDRTQDEIYKMQKGGADLSPELCSAAFPQEKSGSTMNMKFSPIIPKTGSDNGITMDDLHKMNQKNVSAWNMKRLMKIVRNVSLSTLDEQALQNTCEDESTRQIRSEKEAKAAARKIFKNVAQPGTKHIYLEDLMRFLRVDEAMKTMCLFEGALVTKKITKSALKNWLVNAFRERRALALTLNDTKTAVNKLHHMISFLTAIVIIVIWLILLEIATSKYLLFLTSQVVLLAFMFGNSLKTVFESIIFLFIIHPYDVGDRLLIDTVEMVVEEMNILTTVFLRADNLKIVYPNILLWQKAIHNYNRSPDMGDEVTCCVHITTPPEKIAAIKQRISSYIDSKPEYWYPKADVIVKDVEDLNIVRIAIWLCHKINHQNMGERFTRRALLIEEVIKILLELDIQYRFHPLDINVKTMPTVVSSRVPPAWSQNPDLRRIILLEC
What is the function of this protein?
Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.
What are the official names of this protein?
Mechanosensitive ion channel protein 7, Mechanosensitive channel of small conductance-like 7, MscS-Like protein 7.
What is the protein family that this protein belongs to?
Belongs to the MscS (TC 1.A.23) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CD52_MOUSE
Sequence: MKSFLLFLTIILLVVIQIQTGSLGQATTAASGTNKNSTSTKKTPLKSGASSIIDAGACSFLFFANTLMCLFYLS
What is the function of this protein?
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
What are the official names of this protein?
CAMPATH-1 antigen, Lymphocyte differentiation antigen B7.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: CCR5_PONAB
Sequence: MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
What is the function of this protein?
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.  May play a role in the control of granulocytic lineage proliferation or differentiation.  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
What are the official names of this protein?
C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TGT_IDILO
Sequence: MTMKFELDKTSGRARRGRMVFERGTVETPAFMPVGTLGTVKGMTPEEVKDTGAQICLGNTFHLMLRPGTQIIQQHGDLHDFMNWDKPILTDSGGFQVFSLGELRKITEEGVTFRSPINGEKILLTPEKSMQVQRELGSDIVMIFDECTPFPATQAEARSSMELSLRWAERSKQEHGESKAALFGIIQGGMYEELRDISLKGLTDIGFDGYAIGGLSVGEPKEDMMRILEHTAPQMPEQKPRYLMGVGKPEDLVEAVRRGIDMFDCVMPTRNARNGHLFISTGVVKIRNAVHRTDTSPLDENCDCYTCKNYSRAYLHHLDRTNEMLGSRLNTIHNLRFYQKVMSDMRDALDAGTFDDYVKEFYRLRDQSVPALD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SUCC_MYCTU
Sequence: MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVKAQVKIGGRGKAGGVKYAATPQDAYEHAKNILGLDIKGHIVKKLLVAEASDIAEEYYLSFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGHLPAEVLDTAAVTIAKLWELFVAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHAEFEDRAATDPLELKAKEHDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMAAGLDVVLGDQQVKSVFVNVFGGITSCDAVATGIVKALGMLGDEANKPLVVRLDGNNVEEGRRILTEANHPLVTLVATMDEAADKAAELASA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: YCF70_MAIZE
Sequence: MVLYALFYVFLVLFIFFDSFKQESNKLELSGKEERKLGNGEDRLTSDSYLLFFLSYYSLLLLSSDRRSL
What are the official names of this protein?
Uncharacterized protein ycf70, ORF69.
What is the protein family that this protein belongs to?
Belongs to the ycf70 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CMAH_PANPA
Sequence: QTTEILLCLSPVEVASLKEGINFFRNKSTGKDYILYKNKSRLRACKNMCKHQGGLFIKDIEDLAGRSVRCTKHNWKLDVSTMKYINPPESFCQDELVVEMDENNRLLLLELNPPNPWDLQPRSPEELAFGEVQITYLTHACMDLKLGDKRMVFDPWLIGPAFARGWWLLHEPPSDWLERLCQADLIYISHLHSDHLSYPTLKKLAGRRPDIPIYVGNTERPVFWNLNQSGVQLTNINVVPFGIWQQVDKNLRFMILMDGVHPEMDTCIIVEYKGHKILNTVDCTRPNGGRLPMKVALMMSDFAGGASGFPMTFSGGKFTEEWKAQFIKTERKKLLNYKARLVKNLQPRIYCPFAGYFVESHPSDKYIKETNTKNDPNELNNLIKKNSDVITWTPRPGATLDLGRMLKDPTDSKGIIEPPEGTKIYKDSWDFEPYLEILNAAVGDEIFLHSSWIKEYFTWAGFKDYNLVVRMIETDEDFNPFPGGYDYLVDFLDLSFPKERPQREHPYEEIHSRVDVIRHVVKNGLLWDELYIGFQTRLQRDPDIYHHLFWNHFQIKLPLTPPNWKSFLMCCEQNGPGILQFSTERTNEPNRNKFSVENKA
What is the function of this protein?
Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions.  Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.
What are the official names of this protein?
Cytidine monophosphate-N-acetylneuraminic acid hydroxylase, CMP-N-acetylneuraminic acid hydroxylase, CMP-N-acetylneuraminate monooxygenase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the CMP-Neu5Ac hydroxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAR1_HYPJE
Sequence: MVATSFKLNNGLEIPAVGLGTWQSKAGEVKAAVSYALQIGYKLIDGAYCYGNEDEVGEGLKEAFAAGVKREDIFVVTKIWATYNTRVVLGLDKSLRSLGLDYVDLLLVHWPVLLNPEGNHDKFPTLPDGKRDVIWDYNHVDGWKQMEAVLATGKTKSIGVSNYSKKYLEQLLPHATVIPAVNQIENHPSLPQQEIVDFCKEKGIHIMAYSPLGSTGSPLMSADPVVKIAEKKGISPTTVLLSYHVNRGSTVLAKSVTPARIKANLEIVDLDDEDMKLLNDYSNDLASKGELKRYVYPPFGIDFGFPDKS
What is the function of this protein?
Mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process.  Also has activity with D-glucuronate and DL-glyceraldehyde.  No activity is observed with D-glucose, D-fructose, D-xylose, D-galactose, L-arabinose or D-mannose.  Activity is seen only with NADPH and not with NADH.
What are the official names of this protein?
D-galacturonate reductase, D-galacturonic acid reductase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: AQP2_ORYAF
Sequence: SIAFSKAVFSEFLATLLFVFFGLGSALNWPQALPSGLQIAMAFGLAIGTLVQTLGHISGAHINPAVTVACLVGCHVSFLRAIFYVAAQLLGAVAGAALLHELTPPDIRG
What is the function of this protein?
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
What are the official names of this protein?
Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
Protein: UP16_PSEMZ
Sequence: AINSESGVRSVVPQPCNALPNQGPEK
What are the official names of this protein?
Unknown protein 16.
Protein: XGPT_OLEA2
Sequence: MADPDRYNKMFPVSWEQLHRDTRALSWRLMERGPFKGIVAITRGGLVPAAILARELEVRLVDTICIASYDWKSQGGISVLKGVEGDGEGWLIVDDLVDTGTTARAVREMLPKAHFATVYAKPSGRPVVDTYITEVSQDTWILFPWDSEIQYVQPLVNRRQEG
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FURA_MYCTO
Sequence: MSSIPDYAEQLRTADLRVTRPRVAVLEAVNAHPHADTETIFGAVRFALPDVSRQAVYDVLHALTAAGLVRKIQPSGSVARYESRVGDNHHHIVCRSCGVIADVDCAVGEAPCLTASDHNGFLLDEAEVIYWGLCPDCSISDTSRSHP
What is the function of this protein?
Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox-dependent manner.
What are the official names of this protein?
Transcriptional regulator FurA.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_ACISJ
Sequence: MAVWALGINHHTAPLDLRGRFAFALDQIAPTLHGLRDSLSSASGRHPGVETAIISTCNRTEIYCAAEAPALDHTLDWLAHSGGVSPALLRSHSYSLENGLVARHAFRVASGLDSMVLGEAQILGQMKDAVRAAEGAGALGTTLNQLFQRSFAVAKEVRTSTDIGAHSISMAAAAVRLAGQLFEDLSQIRVLFVGAGEMIELCTTHFAAKNPKQISIANRTLERGEKLAARFGGDVMRLADLPDHLHEYDAVISCTASSLPIIGLGAVERSLKKRRHRPMFMVDLAVPRDIEPEVQQLQDAYLYTVDDLASVVQTAQAHRQAAVAQAEAIIDAGVQSFVHWMELRSPATQNGGVVPLIQQLNSQADEWRALEIARAKKRLAKGEDIETVLEALSRGLTQKMLHGTMAELRAGDAEARAQTAQAVSRLFLRSHSKNGL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: CAP3_ECOLX
Sequence: MNMNELVFIDDFDNHVVIMSEVVMRLNSYRQTHYTSTESGGTLIGERRGQHLVITHISEPGQDDVRNRTGLERKGIHHQQKVNDLFQQSNGFIVYLGEWHTHPEDFPHPSFIDIKSWVMGIVATEPMIMLIVGRKDIWIGKKIKNDIKKLKKKMVS
What is the function of this protein?
Protects E. coli against phage infection.  When capV and dncV are introduced in E. coli MG1655 there is 1000-fold protection against phage P1; protection against other phage (T4, T5 and T6) requires the 2 subsequent genes.
What are the official names of this protein?
CD-NTase-associated protein 3, Probable metalloprotease Cap3.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67B family.
Protein: ACTS_CARAU
Sequence: MCDDEEVTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDAGDGVTHNVPVYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETAYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, alpha skeletal muscle, Alpha-actin-1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MILK2_MOUSE
Sequence: MAAIKALQEWCRQQCEGYRDVSITNMTTSFRDGLAFCAILHRHRPDLINFSALRKENIYENNKLAFQVAEEQLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGIKRPSSDSTEELSGKKGLSQPAKLPSPAQTQRSPLSPARTNPVVQRNEGGSQRPSPKAAPGTAGSSVSSICGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSSTLHSGAYRATGEPGVFVCTHHSSEVTSVSPKSSNLASRKPGGVTADTRPFGVSWTVQEANGEGTPLRVRTAAWEHAGGNTTAKGFVQTELKPPSTSQVHVGSSAGPKLPTITVTTTSVTSKALTHVTNSSPIGWSSPAQSSPANFNSRPVVSPSARNTHLPGSQGQTASKGVKTQLNLNSESSNTAVTPAWTSSASKTQQAREKFFQTPPSAPAPASAPAPAPTSKVPTVVTVPTSKVPNVVTAPTSKVPTVVTVPTSKVPTVVSAPTSKVPTVVSAPTSKVPTVVNSTNSRVTTVVNAPTSKVPTVVSATNGRVPTVVTAHTGRVPAVMNTSASKVSPVVDAPAQESSREQALSVLRKALPALTGSGTQAPNRSFPATSSVLVTLPKNEVPQKVPSDKLSALTTQTPNFTIKLEPSAPVNVGNTAVFLQAGKKSPSISPRVGKTSVGSRPQAEVAGVKGPGPISQEGQEEGPEGWRARLKPVDKKTPAGRSLEQKEPVLAEPRIGDTSRKASSSSDSSVHITLTSIQHKRKPCPAGSGPSPAALSPSPSHRKKLAVPPSLDVSADWLQPEPKKQEDGTRSCKEEKSPTRWSRERSAVLDSGLAPPGEAVTSPVRLHPDYIPQEELQRQLQDIESQLDALELRGVELEKRLRAAEGDASEDSLMVDWFRLIHEKQLLLRLESELMYKSKDQRLEEQQLDLQGELRRLMDKPEGLKSPQDRQREQELLSQYVNTVNDRSDIVDFLDEDRLREQEEDQMLENMIQNLGLQRKKSKSFLSKIWSSKSKSGQA
What is the function of this protein?
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization.  Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions.  In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins.  Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.
What are the official names of this protein?
MICAL-like protein 2, Junctional Rab13-binding protein, Molecule interacting with CasL-like 2, MICAL-L2.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Recycling endosome. Cell projection. Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
Protein: GE_BHV1S
Sequence: MQPTAPPRRRLLPLLLPQLLLFGLMAEAEPATETPGSASVDTVFTARAGAPVFLPGPAARPDVRAVRGWSVLAGACSPPVPEPVCLDDRECFTDVALDAACLRTARVAPLAIAELAERPDSTGDKEFVLADPHVSAQLGRNATGVLIAAAAEEDGGVYFLYDRLIGDAGDEETQLALTLQVATAGAQGAARDEEREPATGPTPGPPPHRTTTRAPPRRHGARFRVLPYHSHVYTPGDSFLLSVRLQSEFFDEAPFSASIDWYFLRTAGDCALIRIYETCIFHPEAPACLHPADAQCSFASPYRSETVYSRLYEQCRPDPAGRWPHECEGAAYAAPVAHLRPANNSVDLVFDDAPAAASGLYVFVLQYNGHVEAWDYSLVVTSDRLVRAVTDHTRPEAAAADAPEPGPPLTSEPAGAPTGPAPWLVVLVGALGLAGLVGIAALAVRVCARRASQKRTYDILNPFGPVYTSLPTNEPLDVVVPVSDDEFSLDEDSFADDDSDDDGPASNPPADAYDLAGAPEPTSGFARAPANGTRSSRSGFKVWFRDPPEDDAAPARAPAAPDYTVVAARLKSILR
What is the function of this protein?
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions.  Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions.  Implicated in basolateral spread in polarized cells.  In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system.  Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips (By similarity).
What are the official names of this protein?
Envelope glycoprotein E, gE.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein E family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass membrane protein. Host endosome membrane; Single-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein. The heterodimer gE/gI then redistributes to cell junctions to promote cell-cell spread later in the infection (By similarity).
Protein: MATK_AETGR
Sequence: MEEFKGYFEFDRVRQQNFLYPLFFRESIYVLAYDHGLNKLNRNRSIFLENADYDKKYSLLIVKRLILRMYEQNHLIIPTKDLNHNPFFGQSNLFYYQKISVLFAVIVEIPFSLRLVSSFEGKQLQKSYNLKSIHSIFPFLEDKLLHFNYVLEVRIPYPIHLEILVQTLRYRVKDASSLHFFRFCLYEYCNYKNFDIQKKSILNPRFFFFLYNSHVCEYESLFFFLRKRSSHLRSTSSEVLFERILFYGKIQHLVKVFVNNFPSTLGFLKDPLIHYVRYHGKCILATKDRPLLMNKWKYYFVNLWQSYFFVWLQSQKVNINQLSKDTLEFLGYLSSLQLNPLVVRSQMLKNVFLIETVRIKFDTKIPISSIIGSLAKEKFCNVLGHPVSKSSWTDSSDSEIRERFVRICRNLSHYYSGSSKKKNLYRIKYILRLCCVKTLARKHKSTVRAFLKRLGSGLLEEFLTGEGKIISLIFPRSYYASKRLYRNRIWYLDLLYFNDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DRL10_ARATH
Sequence: MAGELISFGIQNLWNLLSQECELFQGVEDQVTELKRDLNMLSSFLKDANAKKHTSAVVKNCVEEIKEIIYDGEDTIETFVLEQNLGKTSGIKKSIRRLACIIPDRRRYALGIGGLSNRISKVIRDMQSFGVQQAIVDGGYKQPQGDKQREMRQKFSKDDDSDFVGLEANVKKLVGYLVDEANVQVVSITGMGGLGKTTLAKQVFNHEDVKHQFDGLSWVCVSQDFTRMNVWQKILRDLKPKEEEKKIMEMTQDTLQGELIRLLETSKSLIVLDDIWEKEDWELIKPIFPPTKGWKVLLTSRNESVAMRRNTSYINFKPECLTTEDSWTLFQRIALPMKDAAEFKIDEEKEELGKLMIKHCGGLPLAIRVLGGMLAEKYTSHDWRRLSENIGSHLVGGRTNFNDDNNNTCNNVLSLSFEELPSYLKHCFLYLAHFPEDYEIKVENLSYYWAAEGIFQPRHYDGETIRDVGDVYIEELVRRNMVISERDVKTSRFETCHLHDMMREVCLLKAKEENFLQITSSRPSTANLQSTVTSRRFVYQYPTTLHVEKDINNPKLRALVVVTLGSWNLAGSSFTRLELLRVLDLIEVKIKGGKLASCIGKLIHLRYLSLEYAEVTHIPYSLGNLKLLIYLNLASFGRSTFVPNVLMGMQELRYLALPSDMGRKTKLELSNLVKLETLENFSTENSSLEDLCGMVRLSTLNIKLIEETSLETLAASIGGLKYLEKLEIYDHGSEMRTKEAGIVFDFVHLKRLWLKLYMPRLSTEQHFPSHLTTLYLESCRLEEDPMPILEKLLQLKELELGFESFSGKKMVCSSGGFPQLQRLSLLKLEEWEDWKVEESSMPLLRTLDIQVCRKLKQLPDEHLPSHLTSISLFFCCLEKDPLPTLGRLVYLKELQLGFRTFSGRIMVCSGGGFPQLQKLSIYRLEEWEEWIVEQGSMPFLHTLYIDDCPKLKKLPDGLQFIYSLKNLKISERWKERLSEGGEEYYKVQHIPSVEFYHRVLHIFRSVGGDITGRLLMR
What is the function of this protein?
Potential disease resistance protein.
What are the official names of this protein?
Probable disease resistance protein RF45.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
Protein: RL14_EHRRG
Sequence: MIQKNTLLDVADNSGARKVLCIGLLNGKKSASVGDVIVVSTKVVIPRGKVSKGKVYKAVIVRVKKAVRRLDGSVIKFSSNAVVLINDQGDPLGTRVFGPVKKLPFGLFSKVMSLAVEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: LEU1_XANCB
Sequence: MNTTVSNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDALGVDIIETGFPASSYSDREAVAMMGRELRRPTLAVLSRCLQADIEISARALEAAANPRLHVFLSTSPLHREHKLRMSREQVLESVHKHVTLARGYIDDIEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGAEKVIFSTHCHNDLGLAAANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNLDTAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEDEAKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.