PharMolix/UniProtQA huggingface dataset:
Protein: RS7A_CANAL
Sequence: MSSKILSENPTELELKVAQAFVDLESQADLKAELRPLQFKSIKEIDVNGGKKALAVFVPPPSLQAYRKVQTRLTRELEKKFPDRHVVFLAERRILPKPARKARKQQKRPRSRTLTAVHDKILEDLVFPTEIIGKRVRYLVGGNKIQKVLLDSKDSTAVDYKLDSFQQLYSKLTGKQVVFEIPGESH
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).  RPS7A is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
What are the official names of this protein?
40S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS7 family.
Protein: OPSG_RABIT
Sequence: MTQPWGPQMLAGGQPPESHEDSTQASIFTYTNSNSTRGPFEGPNFHIAPRWVYHLTSAWMILVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETVIASTISVVNQFYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIAGIAFSWIWAAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIIPLSVIVLCYLQVWMAIRTVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYSFHPLVAAIPSYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVEDSSELSSASRTEASSVSSVSPA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.  May increase spectral sensitivity in dim light.
What are the official names of this protein?
Medium-wave-sensitive opsin 1, Green cone photoreceptor pigment, Green-sensitive opsin, Medium wavelength-sensitive cone opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: APAH_SHISS
Sequence: MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLQTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGIYALDTGCCWGGTLTCLRWEDKQYFVQPSNRHKDLGEAAAS
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: IF2_PHEZH
Sequence: MSDENNNGRNSAPGGRQPLTLKPRAAGSVSSGTVKQSFSHGRTKTVVVETKRARTHAPAGGNLAAPSAAERRVFEPQKPAGPAQAPRAPQGAGDGLSAEERAARQRAIELARQQEADRRAREERARAEAEAARAAQQKAAQAAAEPPAAPPPAPAAPPAAAAPAAPAAEAAPAPKPAPSPRPVPPSAPAPQAARPAAEAPPRQAGAGQTRTYQPSPDRRDDRPSTTTYRPERPSNRFDTSTFNQRAPRRDDDRGPRPPRRDDDRGPRRDDRPQGARPEGGGTVRYSALAPRPAPGGPRGPGGPRGPGGPRIGAAAPPATPEIQRAARQAPRPGMGVDRRPDEDDRRRDPGKAISRAKGAPNRREGRLTIQAVAGDADGAERMRSLASVRRAREREREKRKGGAQEQARVAREVVIPDVITVGELANRMATRGVEVIKFLMRQGVMLKINDVIDNDTAELVATEFGHTVKRVSEADVEEGFIGAEDVDDHLLPRPPVVAVMGHVDHGKTSLLDALRSTDVVSGEHGGITQHIGAYQVRLADGQRVTFLDTPGHAAFSAMRMRGANVTDIVILVVAADDGVMPQTVEAIQHAKAAGAPIIVAINKIDKPDADPTRVINELLQHEIVVESLGGETQAVEVSATQKMGLDDLIENILLQAEVLDLKANPDRTADGSVIEAKLDKGRGAVATVLVKRGTLKRGDIVVAGSSWGRVRALLNERGEQLQEATPSTPVEILGLDGTPDPGEPFAVVENEARARELTEYRQRVKREKAGAPVASASLADMMAKLADKKVSELPVIIKADVQGSAEAIVGSLDKLATDEVRARIILSGAGAINESDVLLAKGAGAPILGFNVRASKQARDLAEREGVEIRYYAIIYDLIDDIKGVLSGMLAPIQRETFLGNAEVLQAFDITKVGRVAGCRVTEGVVRKGARVRIVREDVVILELGVLKTLKRFKDEVNEVQAGQECGMAFEGFQDIKAGDVIECFNLEEVKRSL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_SYNSC
Sequence: MAIRNFRPYTPGTRTRVVTDFSEITSRKPERTLVVAKHRRKGRNNRGVITCRHRGGGHKRLYRVVDFRRNKHGVPAKVAAIHYDPHRNARLALLFYADGEKRYILAPAGVQVGQTVVSGPDAPIENGNAMPLSSVPLGSAVHCVELYAGRGGQMVRTAGASAQVMAKEGDYVALKLPSTEVRLVRRECYATLGEVGNSEMRNTSLGKAGRRRWLGRRPQVRGSVMNPCDHPHGGGEGRAPIGRSGPVTPWGKPALGLKTRKRNKPSNQYVLRKRRKTSKRSRGGRDS
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: K6PF_PYRFU
Sequence: MIDEVRELGIYTAYNANVDAIVNLNAEIIQRLIEEFGPDKIKRRLEEYPREINEPLDFVARLVHALKTGKPMAVPLVNEELHQWFDKTFKYDTERIGGQAGIIANILVGLKVKKVIAYTPFLPKRLAELFKEGILYPVVEEDKLVLKPIQSAYREGDPLKVNRIFEFRKGTRFKLGDEVIEVPHSGRFIVSSRFESISRIETKDELRKFLPEIGEMVDGAILSGYQGIRLQYSDGKDANYYLRRAKEDIRLLKKNKDIKIHVEFASIQDRRLRKKVVNNIFPMVDSVGMDEAEIAYILSVLGYSDLADRIFMYNRIEDAILGGMIILDELNFEILQVHTIYYLMYITHRDNPLSEEELMRSLDFGTILAATRASLGDINDPRDVKVGMSVPYNERSEYIKLRFEEAKRKLRLKEYKVVIVPTRLVPNPVSTVGLGDTISTGTFLSYLSLLRRHQ
What is the function of this protein?
Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.  As a phosphoryl group donor, ADP can be replaced by GDP, ATP, and GTP to a limited extent.
What are the official names of this protein?
ADP-specific phosphofructokinase, ADP-dependent phosphofructokinase, ADP-Pfk.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOP56_SCHPO
Sequence: MADYLLYESATGYSLFDVVGADQIAAKTKEVQLSLQDISKFGKVVQLRSFIPFKNAAHALENANDISEGVLNDFLKNFLELNLPKASKKKKVSLGVQDKNLATSIKSEIDAIECDTSELTQDLLRGIRFHGDKLLKQLSPGDFERAQLGLGHSYSRAKVKFNVNRNDNMIIQAIAILDQLDKDINTFAMRMKEWYSWHFPELSKIVGDNYKYAVIVTLVGDKTTINDEMLHDLAAVVDDDKDIAQSIINAGKVSMGQDISEIDLENILSFAERVIKLSNYRKQLHNYLVQKMNVVAPNLAELIGEMVGARLISHAGSLTNLSKCPASTVQILGAEKALFRALKTRGNTPKYGIIYHSSFIGKAGAKNKGRISRFLANKCSIASRIDNFSDAPTTAFGQVLRRQVEERLNFFDTGVAPTRNSIAMAEAYEKALSSVNIDGDEEVDIDVEETVETISEKPSKKEKKDKKEKKKEKSKKKRSADDASEEVKKSKKKKKSH
What is the function of this protein?
Required for 60S ribosomal subunit synthesis.
What are the official names of this protein?
Nucleolar protein 56, Ribosome biosynthesis protein sik1.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: LCN15_HUMAN
Sequence: MMSFLLGAILTLLWAPTAQAEVLLQPDFNAEKFSGLWYVVSMASDCRVFLGKKDHLSMSTRAIRPTEEGGLHVHMEFPGADGCNQVDAEYLKVGSEGHFRVPALGYLDVRIVDTDYSSFAVLYIYKELEGALSTMVQLYSRTQDVSPQALKSFQDFYPTLGLPKDMMVMLPQSDACNPESKEAP
What are the official names of this protein?
Lipocalin-15.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KDSB_SHEHH
Sequence: MNVTLLIPARYGSSRFPGKPLAPINGKPMIQHVYERAALAKGLKDIYVATDDERIKNAVEGFGGKVVMTGADAASGTDRIDDAITQLGLADDDLVINLQGDQPLIDPISIEQLVSLCERHPGEFDMATLGVEIRDEAQINDPNHVKMVFDNNFNALYFSRATIPFGRESSDYPVYKHLGIYAYTRKFIQTFAKLPLGRLEDLEKLEQLRALEYGYKIKVAISAFDSPEVDTPEDIRICEARLAVD
What is the function of this protein?
Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus.
What are the official names of this protein?
8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase, CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRH41_ORYSJ
Sequence: MGSCVGKERSDEEDKIDFKGGNVHVISNKENWDHKIAEANKDGKIVIANFSAAWCGPCRVIAPVYAEMSQTYPQFMFLTIDVDELMDFSSSWDIRATPTFFFLKNGEQVDKLVGANKPELEKKVAALADSA
What is the function of this protein?
Probable thiol-disulfide oxidoreductase that may be involved in the redox regulation of a number of cytosolic enzymes.
What are the official names of this protein?
Thioredoxin H4-1, OsTrxh4-1, OsTrx01.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant H-type subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_LACDB
Sequence: MRKIAIDAMGGENAPEAIVEAVLKAKPELPEDKFIFFGDEGKMKELLPADDDQIEIVATTEVILDEDEPVKAMRTKKDSSMVVAANWVKEGKADALLSLGNTGALLTCGIFIVGRIKGVARPGLMPTMPVESSDDGFNIIDVGANATSKPEYLLQWAEMASCYAEKVRGVSKPRVALLNNGAEFDKGDDLHKEVYQLLQDSSLNFTGNIEGHELLQGKADVVVTDGFTGNAVLKSIEGTGSVIIHMLKDGLLNNGVKAKLGALLAKDALKSVASRFDKDKYGGAVLLGLNSPVVKQHGRSDARAVYYAVKQIDKILTEDLTNTFKQEFSK
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: GPC_BPPM2
Sequence: MKITTSIELLDWFKSVVDIDSDYMVSKLTGIPKQTLSTVRTGNSEFSDYTALKLLLVGEHPEPLKGMALLEAHKAERNGNEEQAKLWRKSVA
What are the official names of this protein?
Uncharacterized protein Gp-c.
Protein: ATX3_CHICK
Sequence: MESIFHERQEGSLCAQHCLNNLLQGEYFSPVELSSIAQQLDEEERMRMAEGGVSSEEYRTFLQQPSVNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLGIDPINEKSFICNYKEHWFTVRKLGKQWFNLNSLLMGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQVQRPKLIGEETAQSRDQRLPRSDVDQAIEVSHPFDGTGMLDEDEENFQRALALSRQEIDMEDEEADLRRAIQLSMQGSRQSEFSNSLPQNASQPPHTSQTDSLSSEDLRRRRQAYFEKQQQQLQQQDLTLNLHDKPTINSSTLEADPGGDMSEEDMLQAAMNMSLESARNHLSTEEKK
What is the function of this protein?
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity).  Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity).  Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity).  Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity).  Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (By similarity).
What are the official names of this protein?
Ataxin-3, Machado-Joseph disease protein 1 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: SPHK1_MOUSE
Sequence: MEPVECPRGLLPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPGGSGNALAASVNHYAGYEQVTNEDLLINCTLLLCRRRLSPMNLLSLHTASGLRLYSVLSLSWGFVADVDLESEKYRRLGEIRFTVGTFFRLASLRIYQGQLAYLPVGTVASKRPASTLVQKGPVDTHLVPLEEPVPSHWTVVPEQDFVLVLVLLHTHLSSELFAAPMGRCEAGVMHLFYVRAGVSRAALLRLFLAMQKGKHMELDCPYLVHVPVVAFRLEPRSQRGVFSVDGELMVCEAVQGQVHPNYLWMVCGSRDAPSGRDSRRGPPPEEP
What is the function of this protein?
Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner.  The acetyltransferase activity increases in presence of the kinase substrate, sphingosine.  During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.
What are the official names of this protein?
Sphingosine kinase 1, SK 1, SPK 1, Acetyltransferase SPHK1.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus. Cell membrane. Synapse. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1- dependent manner. Binds to membranes containing negatively charged lipids but not neutral lipids (By similarity). Recruited to endocytic membranes by sphingosine where promotes membrane fusion (PubMed:27806293).
Protein: RS6_BRASB
Sequence: MPLYEHVFLARQDASTQQVEELTTQMTGIVEGLGGKVTKTENWGVRSLTYRMNKNRKAHFVLLNIDAPSAAIAEIERQERISEDVIRYLSVRVDELEEGPSAMMRKADRDRERDDRGGGFRGERDGGGFRGDRGDRGDRGPRRPRDEETADEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RL17_STAA3
Sequence: MGYRKLGRTSDQRKAMLRDLATSLIISERIETTEARAKEVRSVVEKLITLGKKGDLASRRNAAKTLRNVEILNEDETTQTALQKLFGEIAERYTERQGGYTRILKQGPRRGDGAESVIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: UGPA_BRUAB
Sequence: MQKVTFPNKILPYFLLAPQIVLTVVFFFWPASQAIYQSFMREDAFGLKSTFVELANFTAVLSDPNYLHSVQVTVVFNVLTALLAMGVALLLATAADRVIRGQTFYRTLLIWPYAVAPAVAGMLWLFIFNPAMGTFAYLLRRNGIAWDPLLDGNQAMGLVVVAAAWKQISYNFLFFVAGLQAIPKSLIEAAAIDGARGARRFWTIVFPLLAPTSFFLLVVNTVYAFFDTFGIIHAVTGGGPAKATETLVYKVYNDGFVNLNLGSSSAQSVILMAIVIALTAFQFRFVEKRVHYS
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpA.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PAND_ERWT9
Sequence: MNRTMLQGKLHRVKVTQADLNYEGSCAIDQDFLDASGILQYEAVDIYNVNNGQRFSTYAIAAERGSKIISVNGAAARCACEGDLLIICSYVQMSDEQAREWQPKVAYFEGDNQMKRVAKAVPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSPA_BORAP
Sequence: MKKYLLGIGLILALIACKQNVSSLDEKNSASVDLPGEMKVLVSKEKDKDGKYSLKATVDKIELKGTSDKDNGSGVLEGTKDDKSKAKLTIADDLSKTTFELFKEDGKTLVSRKVSSKDKTSTDEMFNEKGELSAKTMTRENGTKLEYTEMKSDGTGKAKEVLKNFTLEGKVANDKVTLEVKEGTVTLSKEIAKSGEVTVALNDTNTTQATKKTGAWDSKTSTLTISVNSKKTTQLVFTKQDTITVQKYDSAGTNLEGTAVEIKTLDELKNALK
What are the official names of this protein?
Outer surface protein A.
What is the protein family that this protein belongs to?
Belongs to the OspA lipoprotein family.
Protein: PGK_PORGI
Sequence: MTIEQFNFAGKKAFVRVDFNVPLDDNFKITDDTRIRAALPTLRKIIADGGMTIIGSHLGRPKGVAPEFSLRHILPHVSELLGVDVLFADDCIGADAMDKAAKLKAGQVLLLENLRFYAEEEGKPRGLSDDASDEEKAAAKKAVKAAQKEFTQKLASMADCYVNDAFGTAHRAHASTALIADYFDRDHKMFGYLMEKEVKAVERVLHDIKRPFTAIMGGSKVSTKIEIIENLLNKVDNLILTGGMTYTFTKAAGGRIGLSIVEDDKLDLARDIVKKAAEKGVNLILSVDTKVADRFDNDAATQVCSNMEIPDDWMGMDIGPRSIEKFRKVILESKTILWNGPTGVFEFDNFSIGSKAVGEAIVEATANGAFSLVGGGDSVACVNKFGLADKVSYVSTGGGALLEAIEGKTLPGIAAIQG
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KEFG_CROS8
Sequence: MMSQTAKVLLLYAHPESQDSVANRVLLKPALQLPNVTVHDLYAHYPDFFIDISHEQALLRDHDVIVFQFPLYTYSCPALLKEWFDRVLSRGFASGVGGNQLAGKYWRCVITTGEPETAYRPDGFNRYALSDILRPFELTAAMCRMHWMTPLIIYWARRQSLSELASHGRAYERWLADPLTPGGF
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefB.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefG, Putative quinone oxidoreductase KefG.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HLDE_SALTY
Sequence: MKVNLPAFERAGVMVVGDVMLDRYWYGPTCRISPEAPVPVVKVNTVEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKTLAEVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALGSIGALVLSDYAKGALTSVQTMISLARQAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVAGKCKSEDELVERGMKLIADYDLSALLVTRSEQGMTLLQPNKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNTLEEACYFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELRQAVASARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGESRPVNPLEQRMIVLGALESVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSEEVWANGGEVMVLNFEDGCSTTNIIKKIQTESEK
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: VF129_ASFWA
Sequence: MEHPSTNYTLEQQHEKLKNYVLIPKHLWSYIKYGTHVRYYTKQNVFRVGGFVLQNPYEAVVKNEVKTAIRLQNSFNTKAKGHVTWAVSYDDISKLYAKPDAIMLTIQENVEKALHALNQNVLTLASKIR
What is the function of this protein?
Plays a role in the inhibition of type I interferon signaling pathway.  Mechanistically, specifically interacts with 2',3'-cGAMP and cleaves it via its phosphodiesterase activity.  In turn, prevents 2',3'-cGAMP interaction with host ER-resident STING1 leading to inhibition of downstream signaling pathway and type I interferon production.
What are the official names of this protein?
Uncharacterized protein C129R, pC129R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus C129R family.
What are the subcellular locations of this protein?
Virion.
Protein: PYRH_PYRFU
Sequence: MRIVFDIGGSVLVPENPDIDFIKEIAYQLTKVSEDHEVAVVVGGGKLARKYIEVAEKFNSSETFKDFIGIQITRANAMLLIAALREKAYPVVVEDFWEAWKAVQLKKIPVMGGTHPGHTTDAVAALLAEFLKADLLVVITNVDGVYTADPKKDPTAKKIKKMKPEELLEIVGKGIEKAGSSSVIDPLAAKIIARSGIKTIVIGKEDAKDLFRVIKGDHNGTTIEP
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_STAHJ
Sequence: MAQTSKYKRVVLKLSGEALAGDKGFGINPIIIKSVAQQVAEVAKMDCEIAVIVGGGNIWRGKTGSDLGMDRGTADYMGMLATVMNALALQDSLEQLECDTRVLTSIEMKQVAEPYIRRRAIRHLEKKRVVIFAAGIGNPYFSTDTTAALRAAEVEADVILMGKNNVDGVYSADPKVDKNAVKYEHLTHIQMLQEGLQVMDSTASSFCMDNNIPLNVFSIMEEGNIKRAVMGEKIGTLITK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZP4_BOVIN
Sequence: MWLLLQLVWLCFLLSLGLNSWHQSKVPEYPDELRCGLRSFQFTINPLSQETETPPVLVAWDNHGLPHSLQNDSDCGTWVSEGPGSSLVGEASYSGCYVTEWESYYIMTVGIERAGVSGSGAFIETKLFKCPVNLPDVPNAGLCDSVPVWDRLPCAPSPITQGDCKQLGCCYNSEEVISCYYGNTVTSHCTQDGHFSIAVSRNVTSPPLLLNSVHLAFRNDSECKPVMATHTFVLFRFPFTTCGTTKQITGKQAVYENELVAARDVRTWSRGSITRDSTFRLQVSCSYSASSSALPVNVQVLTLPPPLPETQPGNLTLELKIAKDKRYRSYYTASDYPVVKLLRDPIYVEVSIHQRTDPSLELRLDQCWATPGADALLQPQWPLLVNGCPYTGDNYQTKLIPVWEASDLPFPSHYQRFSISTFSFVDSVAKRALKGPVYLHCSASVCQPAGTPSCVTLCPARRRRSSDIHFQNNTASISSKGPLILLQAIQDSSEKLHKYSRSPVDSQALWVAGLSGILIVGALFMSYLAIRKWR
What is the function of this protein?
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy.  The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4.  ZP4 may act as a sperm receptor.
What are the official names of this protein?
Zona pellucida sperm-binding protein 4, Zona pellucida glycoprotein 4, Zp-4, Zona pellucida protein B.
What is the protein family that this protein belongs to?
Belongs to the ZP domain family. ZPB subfamily.
What are the subcellular locations of this protein?
[Processed zona pellucida sperm-binding protein 4]: Zona pellucida. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Protein: ZDHC5_HUMAN
Sequence: MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLYVSPAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPDLSRYTGLRTHLGLATNEDSSLLAKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLPGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLGKTPLGRPAVPRFGKPDGLRGRGVGSPEPGPTAPYLGRSMSYSSQKAQPGVSETEEVALQPLLTPKDEVQLKTTYSKSNGQPKSLGSASPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609).  Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs).  Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723).  Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723).  Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609).  Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195).  Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane.  Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780).  Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity).
What are the official names of this protein?
Palmitoyltransferase ZDHHC5, Zinc finger DHHC domain-containing protein 5, DHHC-5, Zinc finger protein 375.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Synapse.