PharMolix/UniProtQA huggingface dataset:
Protein: TPX2_PONAB
Sequence: MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKSGTGGLFQGKTPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLKQKEKHNVKMKAKRCATPVIIDEILPSKKMKVSNKKKPEEEGSAHRDTSEKNASSPEKAKGRHTVPCMPPAKQKVLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSIDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTVVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKIGRDPQTPVLQTKYRARPVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKSEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTEEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRGGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARQQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVSPKFSTRFHC
What is the function of this protein?
Spindle assembly factor required for normal assembly of mitotic spindles.  Required for normal assembly of microtubules during apoptosis.  Required for chromatin and/or kinetochore dependent microtubule nucleation.  Mediates AURKA localization to spindle microtubules.  Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.  TPX2 is inactivated upon binding to importin-alpha.  At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.
What are the official names of this protein?
Targeting protein for Xklp2.
What is the protein family that this protein belongs to?
Belongs to the TPX2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
Protein: NPD2_GEOKA
Sequence: MDQIRQLAQWIKEANTIAVLTGAGMSTESGIPDFRSENGLYAQEDNVEYYLSEYYYKKDPVDFWRRFKRMFSLKMMGGFAPNDGHRFLRWLEEMGKTVTILTQNIDGLHTKAGSTNVIELHGTLQTATCPSCGNKYDLSFINRHEVPRCEKCQTIVKPDVVLFGGLVPRMEEAFAAAAASDLLLAMGTSLEVAPVNQIPFYVAAESPATRKVLINKTATRMDGMFDLVIYGGIGKTVASVRKQIQAE
What is the function of this protein?
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
What are the official names of this protein?
NAD-dependent protein deacetylase 2, Regulatory protein SIR2 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class U subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_LEIXX
Sequence: MGAQLRVYRQKIKSAHRTKKITRAMELISASRIQKEQARVAASSPYARAITRAVSAVATYSNVGHVLTTEPEKIERAVIVIFSSDRGLAGAFNSNVLKESEKLAELLRSQGKEVVYFLIGRKAQGYFSFRRRAFERVWTGNTDAPEFEQAKEVADAILESFLRDSADGGVDEIHVIYNRFVSMLTQEPQVVRLLPMEVVEGVEEPDRTQVLPLYEFEPDVNTVLDSLLPVYIESRIFNAMLQSAASKHAATQKAMKAASDNADKLITDYTRLANNARQAEITQQISEIVGGADALSSAN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL22_PARDP
Sequence: MGKEQNPRRVAENEAFAKTKMLRTSPQKLNLVAAMIRGKKVDKALADLTFSSKRIAGDVKKCLQSAIANAENNHNLDVDNLIVAEAWVGKNLVMKRGRPRARGRYGKIMKPFSEITIKVRQVEERA
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: NORV_SHIDS
Sequence: MSIVVKNNIHWVGQRDWEVRDFHGTEYKTLRGSSYNSYLIREEKNVLIDTVDHKFSREFVQNLRNEIDLADIDYIVINHAEEDHAGALTELMAQIPDTPIYCTANAIDSINGHHHHPEWNFNVVKTGDTLDIGNGKQLIFVETPMLHWPDSMMTYLTGDAVLFSNDAFGQHYCDEHLFNDEVDQTELFEQCQRYYSNILTPFSRLVTPKITEILGFNLPVDMIATSHGVVWRDNPTQIVELYLKWAADYQEDRITIFYDTMSNNTRMMADAIAQGIAETDPRVAVKIFNIARSDKNEILTNVFRSKGVLVGTSTMNNVMMPKIAGLVEEMTGLRFRNKRASAFGSHGWSGGAVDRLSTRLQDAGFEMSLSLKAKWRPDQDALELCREHGREIARQWALAPLPQSTVNTVVKEETSATTTADLGPRMQCSVCQWIYDPAKGEPMQDVAPGTPWSEVPDNFLCPECSLGKDVFEELASEAK
What is the function of this protein?
Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes.  Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified.  NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center.  Also able to function as an aerobic oxygen reductase.
What are the official names of this protein?
Anaerobic nitric oxide reductase flavorubredoxin, FlRd, FlavoRb.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_LISIN
Sequence: MKIAVDAMGGDHAPKEIVLGVMKAVAQYKDIEILLFGDETKINEHLTDKTRVKIIHTDEKIESDDEPVRAVKRKKKASMVLAAQAVKDGEADACISAGNTGALMSTGLFVIGRIKGIDRPALAPTLPTVTGKGFVMLDLGANAEAKPEHLLQFGLMGSVYAEKVRKIERPRVALLNIGTEETKGNELTKKSFELMKNQDAYEFIGNIEARDLLMDVADVVVTDGFTGNMVLKSIEGTGAAFLSMLKMSLLNGFKNKVAASFLKKDLMELKAKMDYSEYGGACLFGVQAPVVKAHGSSNANGIFTTIRQVREMVEKQVVETIKSEVDKVKVGGTETND
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RS15_STRP8
Sequence: MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNSHIKEHKKDHATYRGLMKKIGHRRNLLAYLRRTDVNRYRELIQSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SYA_DICNV
Sequence: MKTMTTAEIRRAFLNYFSENGHKIVHSASLVPGNDPTLLFTNAGMVPFKELFIGTETRDYRRATSAQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKAEAIPFAWRFLTEVLQLPAEKLLVTVYHEDDEAYRIWQEKIGLPADRIIRIGDKAGKAKYESDNFWAMGDTGPCGPCTEIFYDHGAEIFGGRPGSADEDGDRFIEIWNIVFMQFERDAEGTMKPLPKPSIDTGMGLERIAAVMQGVHSNYDIDLFIHLIDAAAKAVGCKNEGQASLKVIADHIRATVFLMVDGVLPSNEGRGYVLRRIMRRAIRHGYKLGQQGLFFHKLVAALVAEMGEAYPEIIAEQARITETIRKEELRFAQTLTAGMQILEQDLATLKGTIISGETVFKLYDTYGFPVDLTNDIARERGLTLDEAGYEALMQAQRERAKASGTFRADKTYTVSGKTAFLAYQQEQTESTIEAIFVQEQAADTLDCGDEAVLVLNQSPFYGESGGQIGDSGVIYHQNGAFLVSDTQKQGDVLLHFGRLQRGVLSVGDTVCAEIDRARRAAIRRHHSATHLLHQALRMTLGTHVQQKGSLVDADKLRFDFSHDAALTAAEIGAVEQLINEQILRNQPVNISEMPYDQACAQGAMALFGEKYGDIVRVVKMGADDFSVELCGGTHVKQTGDLGLVKIIAQSAVAAGIRRVECVAGLAALRYCQQQETQLQRIAAVLKSDLEHSVEKIERLQQDTKTLEKTVQQLKRTVALGGTQETAESVVDIHGWKTMAVRRDDLDNAILRDTADQLRDKYQLDVVVIGSSDGEMARLVVSVAKSAAALKAGAIVQTLAAFIDGKGGGRPDFAQAGGKNIQGLDAALAALPQALPQK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_GLOVI
Sequence: MSTKYETMYILRPDLTDEIIDQTITRYQTLLAEQGAAPVETQHRGKRRLAYELKKFKEGIYVQMNYDAPTTAVAELEKAFRLSEEVIRFLTVREED
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: COIL_MOUSE
Sequence: MAASETVRLRLQFDYPPPATPHCTVFWLLVDLNRCRVVTDLISLIRQRFGFSSGALLGLYLEGGLLPPAESARLVRDNDSLRVKLEDQGLPENLIVSNGGDSSFPCRKAKKRAFKLMEDEETDQGYKSLKKHCKRQEDSGQNEKASDLETKLLPDETGRTKSKKKSKVTGSPAEEDEEETKKKSSKRKEKCEPKKQTRASKSSKQQTPKEGASQNCSFPRASPRSLGKARRRSSTGLKGSSGHLSESESCPESVSDGHCSVMMQEVTFSEKLSAELLKDAPATKTAAANRQASKPGFTFSSGKGKASRTSSSSSDSSSESEDQFLVSKNMLEGASAGFLKPTGLFAGQGGSGPGLSLETPGIMGWKSSDSNRGRQAPGPPSTPVPTSLGRGWGRGEDLLFGKGLRGRGVRGRGRGRGQAVSCVFNRSSESQKQRQLNDILTNSSVVIQNPVEPPKKDYSLLPLLAAAPQVGEKIAFKLLELTSDYSPDVSDYKEGKILSHDPETQQVDIEVLSSLPALKEPGKFDLVYHNENGTEVVEYAVTQEKRITVLWRELIDPRLIIDSSGSISST
What is the function of this protein?
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
What are the official names of this protein?
Coilin, p80-coilin.
What is the protein family that this protein belongs to?
Belongs to the coilin family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, Cajal body.
Protein: RL28_LISMH
Sequence: MAKECVITGRKSRSGNKRSHAMNSSKRTWKANLQKVRILVNGKPKKVWVSARALKSGKVERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: UREF1_BRUAB
Sequence: MTIITPITNDPTTALLRLMAWLSPVFPVGSFSYSHGLERAVHDGLVVDAAGLQDWLQWLVRRGSGWNDAVLCAESWRCAMKGEDLHEIAELAEALAGSRERHMETMLQGGAFFAAARSWPCEIFDRLPPDCAYPVAVGAVAGGHGVPLAQALAAFLQAFCINLLQASIRLSVTGQSGVTAIMAALEPVLGETAARAALSSMEDLGSATFIADIMAMKHETQHSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF 1.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_STRZJ
Sequence: MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQQTVKYADQAYDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLTNWGTIQKRIARLKEIKRMEEDGTFEVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDVMYVVDPHKEQIAVKEAKKLGIPVVAMVDTNTDPDDIDVIIPANDDAIRAVKLITAKLADAIIEGRQGEDAVAVEAEFAASETQADSIEEIVEVVEGDNA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RPOC_PEDPA
Sequence: MIDVNKFESMQIGLASPDKIRMWSYGEVKKPETINYRTLKPEKDGLFDERIFGPTKDYECACGKYKRIRYKGIVCDRCGVEVTKSKVRRERMGHIELAAPVTHIWYFKGIPSRMGLVLDMSPRSLEEIIYFASYVVIDAGETPLEKKQLLTEREYRNKLSEYGDKFVAKIGGEAIQALLETVDLEKEANQLKEELKEASGQKRTRAVRRLDIIEAFLKSGNHPEWMVLDAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPGIIVQNEKRMLQEAVDALIDNGRRGRPVAGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIDVGPSLKMNQMGLPVPMAMELFKPFIMKELVGRGLASNIKNAKRKIDRKDDDVYDVLEDVIKEHPVLLNRAPTLHRLGIQAFEPVLVSGKAMRLHPLACEAYNADFDGDQMAIHLPLSNEAQAEARLLMLAAHHILAPKDGKPVVTPSQDMVIGNYWLTMERAESVGEGMIFNDLDEVRLALQNGYVSIHTRIGVRANSMPEKPFTDAQRKQILITTVGKMLFNDILPKGFVYLNAPTNENLVSGTPDEYFLESGEDIREQLNQRPLIAPFKSGFLSDVIAEVYKQYKVTETSLLLDRMKDLGFYRSTLSGLTVGIADITNLPEKPEIIAAAHKQVATVTKQFRRGLITDDERYERVIGIWNDAKDDIQQRLMETFDPQNPIFMMSDSGARGNISNFTQLAGMRGLMAAPNGKIMELPILSNFREGLSVLEMFISTHGARKGMTDTALKTANSGYLTRRLVDVAQDVIVREKDCGTDRGLLISAIAEGNEMIEPLYDRILGRYTMKSVFNPENGETIIGPNEMINEAIAQQIIEAGVQEVTIRSAFTCNTAHGVCEKCYGRNMATGDRVEVGEAVGTVAAQSIGEPGTQLTMRNFHTGGVAGNADITQGLPRIQEIVESRNPKGPAEISEVTGTVEAIEEDPAEGTKDITIKGETDTRTYTLPITARMKVAEGDYIHRGSALNEGSIDPKELIKVRDVLSTENYLLSEIQKVYRMQGIEISDKHVEIMIRQMLRKVRVMDPGDTDILPGTLMDINDFKNDNYKTLIAGGIPATSRPVILGITKAALETNSFLSAASFQETTRVLTDAAIRGKNDPLVGLKENVIIGKIIPAGTGMTDYRQIKPEVVGGNVEQPQSLSDVEKEMNETVE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: FDH_CANBO
Sequence: MKIVLVLYDAGKHAADEEKLYGCTENKLGIANWLKDQGHELITTSDKEGETSELDKHIPDADIIITTPFHPAYITKERLDKAKNLKLVVVAGVGSDHIDLDYINQTGKKISVLEVTGSNVVSVAEHVVMTMLVLVRNFVPAHEQIINHDWEVAAIAKDAYDIEGKTIATIGAGRIGYRVLERLLPFNPKELLYYDYQALPKEAEEKVGARRVENIEELVAQADIVTVNAPLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALESGQLRGYGGDVWFPQPAPKDHPWRDMRNKYGAGNAMTPHYSGTTLDAQTRYAEGTKNILESFFTGKFDYRPQDIILLNGEYVTKAYGKHDKK
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide.  Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms.  Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
What are the official names of this protein?
Formate dehydrogenase, FDH, NAD-dependent formate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSG_NEIMB
Sequence: MSKKWYVVQAYSGFEKNVQRILEERIAREEMGDYFGQILVPVEKVVDIRNGRKTISERKSYPGYVLVEMEMTDDSWHLVKSTPRVSGFIGGRANRPTPISQREAEIILQQVQTGIEKPKPKVEFEVGQQVRVNEGPFADFNGVVEEVNYERNKLRVSVQIFGRETPVELEFSQVEKIN
What is the function of this protein?
Participates in transcription elongation, termination and antitermination.
What are the official names of this protein?
Transcription termination/antitermination protein NusG.
What is the protein family that this protein belongs to?
Belongs to the NusG family.
Protein: HLX_BOVIN
Sequence: MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADILHAGVGEPGATPEGLAGASAAALTAHLGSAHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGSRVVPNPHQSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLPGLQPSAGQFFASLDPINEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAPDGEPEERSPSRSEGEAESESSDPESLDMAPSDTERTEGTERSLHQTTVIKASAAGALLAASSGGSGGSGGGGGGGFNFGGLSSGSTTSAGSSGSHSSGGASELLPAPQPSLSSAPKSPEPVPAPLGGL
What is the function of this protein?
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression.  Involved in embryogenesis and hematopoiesis (By similarity).
What are the official names of this protein?
H2.0-like homeobox protein, Homeobox protein HLX1.
What is the protein family that this protein belongs to?
Belongs to the H2.0 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1265_GEOTN
Sequence: MIVTTTNTVEGKEIEAYLGIVAAEVILGANVVRDFLASITDIIGGRSGTYESKLAEGRELAIREMVNKATKLGANAVIGVDLDFETLRDGMMMCIATGTAVKVK
What are the official names of this protein?
UPF0145 protein GTNG_1265.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: PT1_ENTFA
Sequence: MSEMLKGIAASDGVAVAKAYLLVQPDLSFNKTSVEDTDAEATRLDDALAKSTEELQAIRDKAAQSLGEAEAQVFDAHLMVLSDPEMVGQIKQNIQDNKVNAEAALKEVTDMYIGMFEAMDDNAYMQERAADIRDVAKRILAHLLGVTLPNPSMINEEVIVVAHDLTPSDTAQLDRTYVKAFVTDIGGRTSHSAIMARSLEIPAIVGTKEITDKVKAGDILAVNGIIGDVIIDPTDAEKSEFEAEAKAYADQKAEWDKLKNAETVTADGKHVELAANIGTPKDLEGVHKNGGEAVGLYRTEFLYMDSSDFPTEEDQYQAYKAVLEGMEGKPVVVRTMDIGGDKELPYLTLPHEMNPFLGYRALRISLSELGDGMFRTQMRALLRASVHGNLRIMFPMVATLKEFRAAKAIFEDEKQKLVNEGVEVSNDIQVGIMIEIPAAAVLADKFAKEVDFFSVGTNDLIQYTMAADRMNERVSYLYQPYNPSILRLIKNVIDAAHAEGKWAGMCGEMAGDQTAVPLLLGMGLDEFSMSATSILKTRSLMKRLDTTKMAELADRALKECDTMEEVFALVEEYTK
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
What are the official names of this protein?
Phosphoenolpyruvate-protein phosphotransferase, Phosphotransferase system, enzyme I.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMD_HAEDU
Sequence: MAIFYSEKTAKQTAKNCCKTTARQIVNIHSLDYQGLDVAKINGKTWFIENALPNEQVLIHVIEEKRQYGRAKANKILQASPLRQQPSCISYPQCGGCQMQHIKLDVQRQTKQQAFFKQLQRLQTEPIDWQPMISGQDKHYRRRTKLSMAIQRNQLVIGFRQQNTHQIIPLTDCEVLEQPLSTLLPKLQHLFAGWKMKKALGHIELVNADNTRAMLVLHIGKINAQDQHMLLNFAKAEQLSLYLMCDENHIEHLCGEAPYYQINGLTLHFCIRDFIQVNQPLNQKMVNKALEWLAITAEDRILDLFCGIGNFSLPIAQQAGFVVGVEGVEEMVKQAKINQQTSGLNNIAFYQTNLAESFVDQHWATQPFNKVLLDPARQGALFCLDHLMALTPERIIYISCNPATLMRDAEKLIRHGYKIAKSAVIDMFPHTGHLESISMFIK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: LACTB_HUMAN
Sequence: MYRLMSAVTARAAAPGGLASSCGRRGVHQRAGLPPLGHGWVGGLGLGLGLALGVKLAGGLRGAAPAQSPAAPDPEASPLAEPPQEQSLAPWSPQTPAPPCSRCFARAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALAKLWEAGKLDLDIPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDIKKVKEEKAYKALKMMKENVAFEQEKEGKSNEKNDFTKFKTEQENEAKCRNSKPGKKKNDFEQGELYLREKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAIVERASGCKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYVDNSYKWAGGGFLSTVGDLLKFGNAMLYGYQVGLFKNSNENLLPGYLKPETMVMMWTPVPNTEMSWDKEGKYAMAWGVVERKQTYGSCRKQRHYASHTGGAVGASSVLLVLPEELDTETINNKVPPRGIIVSIICNMQSVGLNSTALKIALEFDKDRSD
What is the function of this protein?
Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758).  Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758).  It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758).  Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758).
What are the official names of this protein?
Serine beta-lactamase-like protein LACTB, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the peptidase S12 family.
Protein: ATPG_RALPJ
Sequence: MAGTKEIRTKIKSVQNTRKITKAMEMVAASKMRKAQERMRAARPYAEKIRNVAAHMALANPEYKHPFMVARDIKRAGLIVVTTDKGLCGGLNTNVLRAVTTQLRDLQNKGVETQTTAIGTKGMQFLGRVGAKVVSNVVHLGDTPHLEKLIGAIKVQLDAFNAGQIDAVYLAYTRFINTMKQEPVVEQLLPLTADKLAQSDAEKQAYSWDYIYEPDAQTVVDELLIRYVEALVYQAVAENMASEQSARMVAMKAASDNAKNVIGELQLVYNKTRQAAITKELSEIVSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL22_AYWBP
Sequence: METKNAKAIARKVSIAPRKARLVVDLIRGKNIAQAQAILTFTPKVAAPVILKLLNSAVSNAVNNLKLNREQLYVKEVFVNEGFRLKRMFPRAKGSGDMIKKRTSHITLVITSSTNLQTSKEEEQSGSKN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: P2Y12_RAT
Sequence: MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM
What is the function of this protein?
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system.  Required for normal platelet aggregation and blood coagulation.
What are the official names of this protein?
P2Y purinoceptor 12, P2Y12, P2Y12 platelet ADP receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SP2AB_CLOPE
Sequence: MDNKMRLEFLAKSENEGFARVSVSAFIAQLDPTIEELTDIKTAVSEAVTNAIIHGYECDESKVVIIEASICEDEISITVEDNGIGIENLEEAREPLYTSKPELERSGMGFTVMETFMDSLEVYSEKDKGTKIIMKKKMNT
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: NALDL_RAT
Sequence: MHWAKILGVGIGAAALLGLGIILGHFAIPKATEPLASSVSDSQDLDLAILDSVMGQLDASRIRENLRELSKEPHVATSARDEALVQLLLGRWKDSASGLDTAKTYEYTVLLSFPSTEQPNSVEVVGPNGTVFHSFQPFEKNLTGEQAEPNVLQPYAAYAPPGTPKGPLVYANRGSEDDFKKLEAEGINLKGTIALTRYGSVGRGAKAINAARHGVVGVLVYTDPGDINDGKSLPNETFPNSWGLPPSGVERGSYYEYFGDPLTPYLPAHPVSFRLDPHNISGFPPIPTQPIGFEDAKNLLCNLNGTSAPDSWQGALGCEYKLGPGFEPNGNFPAGSEVKVSVYNRLELRNSSNVLGIIQGAVEPDRYVIYGNHRDSWVHGAVDPSSGTAVLLEISRVLGTLLKKGTWRPRRSIIFASWGAEEFGLIGSTEFTEEFLSKLQERTVTYINVDISVFSNATLRAQGTPPVQSVIFSATKEISAPGSSGLSIYDNWIRYTNRSSPVYGLVPSMGTLGAGSDYASFIHFLGITSMDLAYTYDRSKTSARIYPTYHTAFDTFDYVEKFLDPGFSSHQAVARTAGSVLLRLSDSLFLPLNVSDYSETLQSFLQAAQENLGALLESHNISLGPLVTAVEKFKAAAAALNQHILTLQKSSPDPLQVRMVNDQLMLLERAFLNPRAFPEERYYSHVLWAPNTASVATFPGLANAYARAQEINSGAEAWAEVERQLSIAVMALEGAAATLQPVTDL
What is the function of this protein?
Aminopeptidase with broad substrate specificity.  Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position.  Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position.  Lacks carboxypeptidase activity.  Lacks dipeptidyl-peptidase IV type activity.
What are the official names of this protein?
Aminopeptidase NAALADL1, 100 kDa ileum brush border membrane protein, I100, Ileal dipeptidylpeptidase, N-acetylated-alpha-linked acidic dipeptidase-like protein, NAALADase L.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane.