PharMolix/UniProtQA huggingface dataset:
Protein: OXLA_CALRH
Sequence: MNVFFMFSLLFLAALGSCADDRNPLAECFQENDYEEFLEIARNGLKATSNPKHVVIVGAGMAGLSAAYVLAGAGHQVTVLEASERPGGRVRTYRNEEAGWYANLGPMRLPEKHRIVREYIRKFDLRLNEFSQENDNAWYFIKNIRKKVGEVKKDPGLLKYPVKPSEAGKSAGQLYEESLGKVVEELKRTNCSYILNKYDTYSTKEYLIKEGDLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVDGMDKLPTAMYRDIQDKVHFNAQVIKIQQNDQKVTVVYETLSKETPSVTADYVIVCTTSRAVRLIKFNPPLLPKKAHALRSVHYRSGTKIFLTCTTKFWEDDGIHGGKSTTDLPSRFIYYPNHNFTNGVGVIIAYGIGDDANFFQALDFKDCADIVFNDLSLIHQLPKKDIQSFCYPSVIQKWSLDKYAMGGITTFTPYQFQHFSDPLTASQGRIYFAGEYTAQAHGWIDSTIKSGLRAARDVNLASENPSGIHLSNDNEL
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:11248687, PubMed:8080286).  Shows high affinity for L-Phe, L-Trp, L-Met, L-Leu, and L-Ile, moderate affinity for L-Arg, L-Asp, and L-His, and very low affinity for L-Gln, L-Lys, and L-Ala (PubMed:8080286).  Also shows high activity on L-norleucine (L-2-aminohexanoate), and L-norvaline (L-2-aminopentanoate) and a weak activity on L-ornithine and L-aminobutyric acid (PubMed:8080286).  Also exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, and antiparasitic activities, as well as regulation of platelet aggregation (By similarity).  Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation.  These different effects are probably due to different experimental conditions (By similarity).  A possible explanation of high efficacy it that LAAO may bind to target cells through its sialylated glycan moiety that would bind to sialic acid-binding lectins (siglec) on target cells (PubMed:11453999).  This interaction may result in production of locally high concentrations of hydrogen peroxide in or near the binding interface, leading, in turn to oxidative damage of the siglec or another adjacent cell structural elements (PubMed:11453999).
What are the official names of this protein?
L-amino-acid oxidase, LAO, MPV-LAAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS6_ANOFW
Sequence: MITKRIIPCLDVKDGRVVKGVQFVSLRDAGDPVELARAYDEQGADELVFLDISASHEGRKTMVDVVRRVAAQLAIPFTVGGGISTLEDMKTILRAGADKVSVNTAALLRPELITEGANFFGSQCIVVAIDAKYDETMQSWRVYTHGGRRPTDWEVVAWAKEAVKRGAGEILLTSMDRDGGKDGFDLALTKRVSEAVSVPVIASGGAGCAQHFVDVFQTAQADAALAASIFHYQETSVQQVKQYVREQGVNVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1437_STRPD
Sequence: MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENALIGVNDHTLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGVSYYCNLASPYMMDTEALKYIDYDLDVKVFADGEKRLLDVDEYEIHKKEMQYSADMDFILKENVKILVDWINHEKGPFSKAYITIWYKRYLELKNR
What are the official names of this protein?
UPF0374 protein MGAS10270_Spy1437.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: Y674_METJA
Sequence: MKLGRYLAVSKDLAPAKFIIAKCIEVEEFKGLELNELWEIHNKVLKKVDFDNFDFNDLEYVKPNLLDLKVEIAKNIFKNCHFCEHRCYVNRETERGFCRIKESYYSTEFLHLGEERVLVPSHTIFFCGCNFKCVFCQNWDISQVYFDKTIPNHCIPYNPKEMAKIIKHKRDYSKNVNFVGGDPTPHLLSILKTLSYLDKNIPVVWNSNMYLTVEGMHLLKGVVDVYLTDFKFGNNECGERLSKVKNYFDIIKRNHLLIKDEEVIIRHLVMPNHLDCCTEKIFDFISKNLDNAVVNVMFQYRPEYKAKEYPDINRRLTYEEIEKALELAEKYNLDLIYD
What are the official names of this protein?
Uncharacterized protein MJ0674.
Protein: GPI3_YEAS6
Sequence: MGFNIAMLCDFFYPQLGGVEFHIYHLSQKLIDLGHSVVIITHAYKDRVGVRHLTNGLKVYHVPFFVIFRETTFPTVFSTFPIIRNILLREQIQIVHSHGSASTFAHEGILHANTMGLRTVFTDHSLYGFNNLTSIWVNKLLTFTLTNIDRVICVSNTCKENMIVRTELSPDIISVIPNAVVSEDFKPRDPTGGTKRKQSRDKIVIVVIGRLFPNKGSDLLTRIIPKVCSSHEDVEFIVAGDGPKFIDFQQMIESHRLQKRVQLLGSVPHEKVRDVLCQGDIYLHASLTEAFGTILVEAASCNLLIVTTQVGGIPEVLPNEMTVYAEQTSVSDLVQATNKAINIIRSKALDTSSFHDSVSKMYDWMDVAKRTVEIYTNISSTSSADDKDWMKMVANLYKRDGIWAKHLYLLCGIVEYMLFFLLEWLYPRDEIDLAPKWPKKTVSNETKEARET
What is the function of this protein?
Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
What are the official names of this protein?
Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit, GlcNAc-PI synthesis protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: CALM2_ARATH
Sequence: MADQLTDDQISEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIKEADVDGDGQINYEEFVKVMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin-2, CaM-2.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Note=Recruited by IQD1 to microtubules.
Protein: YIDD_SHEWM
Sequence: MAKTQSPLQWLATTLIRGYQVFISPFLGANKCRFHPTCSTYAIEAIRLHGSVKGCWLAARRILKCHPLHPGGIDPVPPKTHRCNK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ENOPH_DICDI
Sequence: MTPNIHTVILDIEGTTTPISFVHDVLFPYIRDNLVRHINQKWGSEELKQDIKELYKLYLEDNKASELVVNNQFNTPEILNPDDESTDKEKLIESVIRNVIYQMDNDRKSTPLKQLQGHMWLEGYENELVKGVVFPEVPKAFENWNLNHIDIYIYSSGSIAAQKLLFNYSNFGSLLPYIKGHFDTTIGGKLHPSSYEKILSTINNGSPNSYLFVTDSILEAKAARESGLNVCLSIRDGNPPIVDRELLNTFDQVSSFDQLFNKFNFKN
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS7_STAAC
Sequence: MPRKGSVPKRDVLPDPIHNSKLVTKLINKIMLDGKRGTAQRILYSAFDLVEQRSGRDALEVFEEAINNIMPVLEVKARRVGGSNYQVPVEVRPERRTTLGLRWLVNYARLRGEKTMEDRLANEILDAANNTGGAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RU2A_CANGA
Sequence: MKFTPGAVEDAPSYYVDHDNGKYNTQKCVILRNLGLEGDDIAMPASLNHLAKPTHILDLTNNDLVFFPDLHHRDDIETLLLSKNRLMVLDAALLPSKLKSLSLAFNGIENFETLIPLSHCPSTVRDLVLIGNPICHLSEYRQRILALVPSLEVLDFKLVSQAEKAQAVKDHVAVMKKIKEDNRQIHQRKKKALAAEVDGKNTFGRNTKSLTEAAKVTKPRDKTIEVMNTVVGKLTEEKKKKIREQLANASSMEELERLERLLTGGV
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
U2 small nuclear ribonucleoprotein A', U2 snRNP A'.
What is the protein family that this protein belongs to?
Belongs to the U2 small nuclear ribonucleoprotein A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EAF3_DICDI
Sequence: MDETYEENEKVLVHHQNRIYEAKIIKVDPKTSKSDKKKPLYFIHYLGWKEKWNEWIEPNKILKYTDKNRELQKRTNIKASTTSLNNKKNTKKAKEVKQQQQQQQPIAYDSENSDEDENESELEDGGGEDADEGGEDIEDQENNNNNDTGGEEADDNNTSPRSTGSSSSSSSSKSNNNNNNNNNNNNNNNNNNNNNNNNNNKRKRNDSKSSHFQSTKFIDIEIPLSLKNKLVDDWNSINNEKSILSLPKSPNVKDILNKIIEENDKSSECKEVINGIKQYFNKALGTLLLYKFERPQYDSILKTNPKKSMSDIYGAEHLLRLFVKLPQLLVISNLEEKTITQLKDAFEIVLEYLEKNSSTLFLKEYTIASSPYLKAASSN
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair.  Also a component of a complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).
What are the official names of this protein?
NuA4 complex subunit EAF3 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: RABL6_HUMAN
Sequence: MFSALKKLVGSDQAPGRDKNIPAGLQSMNQALQRRFAKGVQYNMKIVIRGDRNTGKTALWHRLQGRPFVEEYIPTQEIQVTSIHWSYKTTDDIVKVEVWDVVDKGKCKKRGDGLKMENDPQEAESEMALDAEFLDVYKNCNGVVMMFDITKQWTFNYILRELPKVPTHVPVCVLGNYRDMGEHRVILPDDVRDFIDNLDRPPGSSYFRYAESSMKNSFGLKYLHKFFNIPFLQLQRETLLRQLETNQLDMDATLEELSVQQETEDQNYGIFLEMMEARSRGHASPLAANGQSPSPGSQSPVVPAGAVSTGSSSPGTPQPAPQLPLNAAPPSSVPPVPPSEALPPPACPSAPAPRRSIISRLFGTSPATEAAPPPPEPVPAAEGPATVQSVEDFVPDDRLDRSFLEDTTPARDEKKVGAKAAQQDSDSDGEALGGNPMVAGFQDDVDLEDQPRGSPPLPAGPVPSQDITLSSEEEAEVAAPTKGPAPAPQQCSEPETKWSSIPASKPRRGTAPTRTAAPPWPGGVSVRTGPEKRSSTRPPAEMEPGKGEQASSSESDPEGPIAAQMLSFVMDDPDFESEGSDTQRRADDFPVRDDPSDVTDEDEGPAEPPPPPKLPLPAFRLKNDSDLFGLGLEEAGPKESSEEGKEGKTPSKEKKKKKKKGKEEEEKAAKKKSKHKKSKDKEEGKEERRRRQQRPPRSRERTAADELEAFLGGGAPGGRHPGGGDYEEL
What is the function of this protein?
May enhance cellular proliferation.  May reduce growth inhibitory activity of CDKN2A.
What are the official names of this protein?
Rab-like protein 6, GTP-binding protein Parf, Partner of ARF, Rab-like protein 1, RBEL1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Note=Predominantly cytoplasmic (PubMed:17962191). SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Note=Predominantly nuclear (PubMed:17962191).
Protein: MHPD1_PSEPU
Sequence: MTISQETLERLAADLRRAEQQGEAIPPLRDAIGAENGEAAYAIQRLNVAHALAAGRRLVGRKVGLTNPKVQAQLGVDQPDFGCLFADMAYGDNETVPFDRVLQPKIEREIALVLERDLPARTPTWPNVANRHRLGACRPLEIVGTVSPTWNIRFADTVADNASSGLFVLGGPARRLDGLDLRGAAMRMTRNDELVSSGSGAECLGHPLNAAVWLARTLARLGDPLKAGDIVLTGALGPMVAVNAGDRFDAEIDGLGRVGVTFSQS
What is the function of this protein?
Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.
What are the official names of this protein?
2-keto-4-pentenoate hydratase 1, 2-hydroxypentadienoic acid hydratase 1.
What is the protein family that this protein belongs to?
Belongs to the hydratase/decarboxylase family. MhpD subfamily.
Protein: RL2_BACC4
Sequence: MGIKKYNPTTNGRRNMTTNDFAEITTDRPEKSLLAPLSKKAGRNNQGKITVRHQGGGHKRQYRIIDFKRNKDGIPGRVATIEYDPNRSANIALINYVDGEKRYILAPKSLEVGMEVMSGPEADIKIGNALPLINIPVGTVVHNIELKPGRGGQLVRSAGTSAQVLGKEGKYVLVRLTSGEVRLVLSACRASIGQVGNEQHELIKIGKAGRSRWLGKRPTVRGSVMNPVDHPHGGGEGRSPIGRKSPMSPWGKPTLGFKTRKKNKASDKFIVRRRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SECA_SHELP
Sequence: MFGKLLTKIFGSRNDRTLKTLGKIVTKINALEADFEKFSDEELKAKTAEFKQRLESGQTLDDVMPEAFAVVREASKRVFEMRHFDVQLLGGMVLDSNRIAEMRTGEGKTLTATLPAYLNALTGKGVHVITVNDYLARRDAENNRPLFEFLGMTVGVNIAGMGQAEKKMAYASDITYGTNNEFGFDYLRDNMAFSPNERVQRPLHYALIDEVDSILIDEARTPLIISGAAEDSSELYIKINTLIPHLIRQDKEDTEEEIGDGDYSIDEKAKQVHMTERGQEKVEVLLTERGMLAEGDSLYSAANISLLHHVNAALRAHTLFEKDVDYIVQDNEVIIVDEHTGRTMPGRRWSEGLHQAVEAKEGVHIQNENQTLASITFQNFFRQYEKLAGMTGTADTEAFEFQHIYGLDTVVIPTNRPMVRKDHADLVYLTAEEKYDAIIKDIIDCRDRGQPVLVGTVSIEQSELLHSMLKKAKIPHEVLNAKFHEREAEIVAQAGRSGAVTIATNMAGRGTDIVLGGNWNMEIDALENPTAEQKAKIKADWQVRHDEVVAAGGLHILGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDSLMRIFASERVSSMMKKLGMEKGEAIEHPWVSRAIENAQRKVEARNFDIRKQLLEFDDVANDQRQVVYAQRNELMDAESIQDTIVNIQADVVNGLIDQYIPPQSVEELWDIAGLETRLEQEYALRMPVQEWLDKEDDLHEETLRERIVEIWVKAYKAKEEMVGAQVLRQFEKAVMLQTLDGLWKEHLAAMDHLRQGIHLRGYAQKNPKQEYKRESFELFQQMLESLKHDVISILSKVQVQAQSDVEEMEERRRQEEAKVRRDYQHAEAEALVGAEEAQALAATQPVVREGEKVGRNDPCPCGSGRKYKQCHGKLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: HCHA_ECO8A
Sequence: MTVQKSKNPQVDIAEDNAFFPSEYSLSQYTSPVSDLDGVDYPKPYRGKHKILVIAADERYLPTDNGKLFSTGNHPIETLLPLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMPFFEQHKSLFRNPKKLADVVASLNADSEYAAIFVPGGHGALIGLPESQDVAAALQWAIKNDRFVISLCHGPAAFLALRHGDNPLNGYSICAFPDAADKQTPEIGYMPGHLTWYFGEELKKMGMNIINDDIAGRVHKDRKVLTGDSPFAANALGKLAAQEMLAAYAG
What is the function of this protein?
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals.  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals.  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE).  Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA.  Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair.  Plays an important role in protecting cells from carbonyl stress.
What are the official names of this protein?
Protein/nucleic acid deglycase HchA, Maillard deglycase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family. HchA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_MYCVP
Sequence: MADFVAAIDQGTTSTRCMIFDHDGAEVGRHQLEHEQILPRAGWVEHNPVEIWERTGSVLATALNKTKLSTSDLVALGITNQRETSLVWNRHTGRPYYNAIVWQDTRTDRIASALDRDGRGDVIRQKAGLPPATYFSGGKLQWLLENVDGLRADAEKGDALFGTTDTWVLWNLTGGHRGGVHVTDVTNASRTMLMNLETLDWDDELLGFFDIPRQMLPEIRPSSSPEPHGVTVDWGPADGEIPVTGILGDQQAAMVGQVCLDAGEAKNTYGTGNFLLLNTGENIVRSKNGLLTTVCYQFGDAKPVYALEGSIAVTGSAVQWLRDQLGIISGAAQSESLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHVARATLEAICYQSRDVVDAMAADSGVHLEVLKVDGGITANDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWDGADDLRANWQEDKRWSPTWSDDQRAAGYAGWRKAVQRTMDWVDVD
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: ZNF66_HUMAN
Sequence: MGPLQFRDVAIEFSLEEWHCLDMAQRNLYRDVMLENYRNLVFLGIVVSKPDLITHLEQGKKPSTMQRHEMVANPSVLCSHFNQDLWPEQSIKDSFQKLILRRHKKCGHDNLQLKKGCESVDKCKVHKRGYNGLNQCLTTTQSKMFQCDKHGKVFHQFSNTNRHKIRHTGKNPCKFTECGKAFNRSSTFTTHKKIHTGEKPYKCIECGKAFNRSSHLTTHKIIHTGEKRYKCEDCGKAFNRSSNLTTHKKIHTGEKPYKCEECGKAFKRSSILTTHKRIHTGEKPYKCEECGKVFKYLSSLSTHKIIHTGEKPYKCEECGKAFNWSSHLTTHKRIHTGEKPYKCEECGKGFKYSSTLTKHKIIHTGEKPYKCEECGEAFKYSCSLTAHKIIHTGKKPYKCEECGKVFKHSSPLSKHKRIHTGEKPYKCEECGKAFSRSSILTTHKIIHTGEKPYECEDCGKAFNRSSNLTKHKKIHTGEKPYKCEECGKAFKCSSILTTHKRIHTADKPYKCEECGKDFKYSSTLTRHKKIHTGGKPHKCNKCGKAFISSSNLSRHEIIHMGGNPYKCENVAKP
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Putative zinc finger protein 66, Zinc finger protein 66 pseudogene.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYB_ANGMO
Sequence: MANLRKTHPLLKIANDALVDLPTPSNISAWWNFGSLLGLCLISQILTGLFLAMHYTSDISTAFSSVAHICRDVNYGWLIRNLHANGASFFFICLYLHIARGLYYGSYLYKETWNIGVVLFLLVMMTAFVGYVLPWGQMSFWGATVITNLLSAVPYVGDSLVQWIWGGFSVDNATLTRFFAFHFLFPFVVAGATMLHLLFLHETGSNNPVGLNSDADKIPFHPYFSYKDLLGFIIMLTALTMLALFYPNLLGDPDNFTPANPMVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLSSILVLMVVPILHTSKQRGLTFRPISQLLFWILVADMLVLTWIGGMPVEHPYIIIGQVASVLYFSLFLVLNPLVGWLENKVMNW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ACLH_ASPOR
Sequence: MSIPNRCTVLVVGGGPAGSYAAAALAREGVDTVLLEADVFPRYHIGESMLPSIRHFLRFIDLDSKFDSYGFVNKNGAAFKLNSKPEAYTDFIAAGGPGSHAWNVVRSEADHLMFKHAGENGAQVFDGVKVNSIEFEQIDGLTVDPSLSELGRPVSATWSCKATGGKGSITFEYLIDATGRAGLVSTKYMKNRRYNQGLKNVASWGYWSNAGSYGVGTPREGDPYFEAIEDGSGWVWLIPLHNGTTSIGVVMNQEAATAKKRETGATTKDLYLNTIKNTPGVWQLLDKAELQSDLKSASDWSYNASSYASPYLRIVGDAGCFIDPFFSSGVHLALASGLSAALTIRAAQRGDCDEQAAVSWHSKKVAEGYTRFLLVVMSALKQISDREKPVLTDFDEDSFNRAFDFFRPIIQGTADVDKNLTQAEIAQTIEFCVQAFQTASTDEQDAVMTKVAAINSQNGTEGALRELHASLSADERRTLTTIQARQIIRSEDQMNIDNFTIDVIDGMVPRLERSSLGLARFVPKAQTSREDGLRATLGLPEKQKSIFSY
What is the function of this protein?
Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells (PubMed:25302411).  The non-ribosomal peptide synthetase (NRPS) aclP is responsible the formation of the diketopiperazine (DKP) core from the condensation of 2 phenylalanine residues (PubMed:25302411).  One Phe residue is tailored into chlorotyrosine by hydroxylation and chlorination, whereas the second Phe undergoes an unprecedented C-C bond cleavage to be converted into glycine (PubMed:25302411).  After formation of the DKP, sulfur is incorporated into the DKP by conjugation with glutathione by aclG, followed by its stepwise degradation to the thiol by aclI, aclJ and aclK, and the dithiol oxidation by aclT (PubMed:25302411).  In addition, oxygenases (aclB, aclC, aclL and aclO) and O-methyltransferases (aclM and aclU) act as tailoring enzymes to produce the intermediate dechloroaspirochlorine (PubMed:25302411).  Ultimately, chlorination of dechloroaspirochlorine by the halogenase aclH is the last step in the aspirochlorine pathway (PubMed:25302411).
What are the official names of this protein?
Flavin-dependent halogenase aclH, Aspirochlorine biosynthesis protein H.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: FTSY_HELPJ
Sequence: MFNFFKKIVNKIKGEEVKEKKRESVPKEELEEILIGFDIQYDLIESLLKHLGDLITPKQLEVALLRFVRGESYYDKTRLKTITTKPLVHLIVGVNGAGKTTTIAKLAKLSLKQHKKALLGAGDTFRAAAVKQLQLWGEKLNVQVISAKEGSDPSSLAYNTIESAIAKNIDEVFIDTAGRLHNQTNLKNELSKIAHTCSKVLKDAPFYKFLILDGTQGSSGLTQAKIFHETLALDGVIMTKLDGTSKGGAILSVLYELKLPILYLGMGEKEDDLIAFDEERFIEDLVDAVFVEQ
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).  Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
What are the official names of this protein?
Signal recognition particle receptor FtsY, SRP receptor.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. FtsY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: ALBB_STRNR
Sequence: MNPGETVLPPQLREEIALLAVYLLSSGRGLLEEPADYGIYRCTDGARRALQLLDEHGGSTARLTAVRERLDEVMFAPMGEDRDMGAILDDLCRQMADALPEIETP
What is the function of this protein?
Involved in the biosynthesis of albonoursin (cyclo[(alpha,beta-dehydro-Phe)-(alpha,beta-dehydro-Leu)]), an antibacterial peptide.  AlbB is essential for cyclic dipeptide oxidase AlbA (CDO) activity.
What are the official names of this protein?
Protein AlbB, Albonoursin synthase protein B.