PharMolix/UniProtQA huggingface dataset:
Protein: THADA_CANLF
Sequence: MGVKKKKEMQVTALTICHQDLETLRFLADVEGKNLASLLLYCVQLTDGVSQIHYVKQIVPLLEKADKNGACDPIIRSCLDILAGIYLSLSVKNPLKKVLASSLNGLPEFFLTEAIQSFTSRLQEELNTTDLYSYRKVIDNISSCMENFDLGRAGVNNLLKNVLHFLQKSLIEISEENRKFAGNRIVQTQLMNDLLVGTRVSVMLVQKIQDIQRIHLKTSSSPTWQSMCGLLSIFTKFLSDDDLLQTIQSTSGLAVILFIKAMFHPPEKIPDLISSLLLRSVDCTSIPDWFLNCCRSLCCTDVSQSTLLFLCQGTLTMLDWQNGSMDLSGEALLLNIVHILFTLSSQIKESTLELFLSRILASWTNSAIHVLKSSSPSLKNSLNGKSSVVGRLLEYVYTHWEHPLDALRHQTKIIFRNILQMHQLTKEKSNSEVSGLAADHFICDLTEGLLRLEWHVKGKYTCLGCLVDYIGIGHILALAKTIPSQILEVMGDQSLVPYASDLLETMFRSHKNHLKSQALDSTWIDEWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLNCSPESLSYMVKILQTSADAKTGSYNSRGALGALMACLRTARAHGHLQSATDTWRNLVSSARIKQGLIHQHCQVRIDTLGLLCESNRSTEIVSTEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKQEQSRSKHEPENELTKQHPSVSLQQYKNFMSSICSHLFEALFPGSSYPTRFSALTILGSIAEVFPVTEGQVQAVYQLSHDIDVGRFQTLMECFTSTFEEVKILAFDLLMKLPKTVVQFQDSEKLQGLFQAALELSSSTKPYDCVTASYLLNFLIWQDVLPSSLFDSLKTQQTACEDGDKSAIVVERNTLMVIKCLLENLEEEVSQAENSLLQAAASFPLYGRVHCVTGALQRLSLNNLQLVSEWRPVIEKLLLMSYRLSAVVSPVIQSSSPEGLIPMDTDSESASRLQTILNEIQPRDTNDYFTQAKILKEHDSFDLEDLNVSVQNIGASAEVKGKERKTCDVTAQMVLVCCWRSMKEVALLLGTLCQLLPMQSVPESSNGLLTEEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEILNRCPNVSLQKLPEQWLWNVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGKMDLLKITMKELISLAGPTDDSQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSTLITRIFGVKRGKDELSKKNRMTGSEFFSRFPELYPFLLQQLEAVANTVDSDTGELNRHPSMFLLLLVLGRLYPSPMDGTYSALSMAPFIPFIMRCGRSPDYRSREMAARALVPFVMVDEIPTTIRTLLAKLPNCTDQRFRQNHIHGTLLQVFHLLQAFTDSKYRLNTYFQQELADVAVCTRAKLWLAERQNPCLVTRAVYIDILFLLTRCLDKPTKGNQPAVECLGFWEDVRRIISGSELITGFTYTFTVPGLPQYLQSLTKLAITTAAVAAQAGEQAGNIPISFSQLLESSFPEVRLLTLEALLERFSTAALGLGEKGLPPLQRNMGETFLMLAVKENHPECFCKILKILHCMDPSEWLSHMQRCIHLTPKEFLIWTMDIASNERSEVQSVALRLASRVIAHHLQMCEETRDSVAPTLKQWVQLVVSSCGEHLPTESRLAAAEALTSTTPFLLTSPHPVLGLQDTLALWRCVLTLLQSEEQAVRDAATGTVVTAMSQENTCRSTEFAFCQVDASIALTLALAVLCDLLQQWDQLALGLPVLLGWLLGEDDDFVVHLENTHQVEDYLFEKAEINFWAETLIFVKYLHEHLLRLLSTSSRRPLSPESLRHLRRTASEQGHLLSQLFRELPPAAEFLKTVEFTRLRIQEERTLACLQLLAFLEGKEREDTPVLRASDSPAEANQFTLAKTETAH
What are the official names of this protein?
Thyroid adenoma-associated protein homolog.
What is the protein family that this protein belongs to?
Belongs to the THADA family.
Protein: RL43_CANGA
Sequence: MAKRTKKVGITGKYGVRYGSSLRRQVKKLEVQQHARYDCSFCGKKTVRRGAAGIWSCHSCKKTVAGGAYTVSTAAAATVRSTIRRLRDMVEA
What are the official names of this protein?
60S ribosomal protein L43.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
Protein: Z_IPPYV
Sequence: MGQNQSRDKQKAIQNQPKDTGNRADIIPDATGMGPEFCKSCWFERRSLVACNNHYLCMNCLTLLLSVSERCPICKLPLPQKLKLTSSPSAPPSPSPPPYSP
What is the function of this protein?
Plays a crucial role in virion assembly and budding.  Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L.  Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP.  Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway.  The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z.  Also selectively represses protein production by associating with host eIF4E.
What are the official names of this protein?
RING finger protein Z, Protein Z, Zinc-binding protein.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae Z protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm, host perinuclear region. Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Mainly perinuclear. During budding, associates at the inner side of the plasma membrane of infected cells.
Protein: YIDC_SALTI
Sequence: MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQTQQTMQTTTTAAGSAADQGVPASGQGKMITVKTDVLDLTINTRGGDVEQALLPAYPKELGSNEPFQLLETTPQFIYQAQSGLTGRDGPDNPANGPRPLYNVEKDAFVLADGQNELQVPMTYTDAAGNTFTKTFVFKRGDYAVNVNYSVQNTGEKPLEVSTFGQLKQSVNLPPHRDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIADNENLNVSSKGGWVAMLQQYFATAWIPRNDGTNNFYTANLGNGIVAIGYKAQPVLVQPGQTGAMTSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLMGSIELRHAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS27A_METKA
Sequence: MGVPRRAKLYEVKDGKVERKNPFCPRCGPGVFMADHGNRYACGRCGYTEFKDQPEPKKKK
What are the official names of this protein?
30S ribosomal protein S27ae.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS31 family.
Protein: MSHB_STRRD
Sequence: MTDRRLLLVHAHPDDETIGSGATMAKYAAEGAHVTLVTCTLGEEGEVIPAELAHLAADRDDTLGEHRVGELAAACEALGVTDHRFLGGAGRWRDSGMMGVASNHRDNAFWQADLDEAAGELVKVIREVRPQVLVTYDQNGFYGHPDHIQAHRVSWRAFELAADPAFGEGEPWRIAKFYFTATARSTMHRTAEALREADVSFLTEDAIDDLPFGCADEDVTTEIDGRAHVGRKLDAMRAHATQISVEAPWFALSNNIGQEALAVEHFILRSGVPGPAGPGAPLEVGGLGEPYDREADLFAGIH
What is the function of this protein?
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
What are the official names of this protein?
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, GlcNAc-Ins deacetylase, N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family.
Protein: OTC_STRAW
Sequence: MATVPTALAGRHFLKELDFTAEEFRGLLELAAELKAAKKARTETLYLRGRNIALVFEKTSTRTRCAFEVAAADQGASTTYLDPAGSQIGHKESVKDTARVLGRMFDGIEYRGHGQGVVEELAAHAGVPVYNGLTDEWHPTQMLADALTMTEHSDKPLTEIAYAYLGDARYNMGNSYLVTGALLGMDVRIVAPRLLWPDETIVEVAQQLAVASGARITLTEDVKEGVRGADFVATDVWVSMGEPKEVWDERIGLLGPYAVTMDVLRATGNDDVKFLHCLPAFHDLGTDIGREIHARHGLTSLEVTDEVFESAHSVVFDEAENRMHTIKAVLVATLA
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C71AO_ARATH
Sequence: MKMMMMIILLLCSIILITILFFKKQSRGKKSNAPPSPPRLPLIRNLHQLGRHPHRSLCSLSHRYGPLMLLHFGSVPVLVVSSADAAKDVLKTHDRVFASRPRSKIFDKIFYNGRDVALAPYGEYWRQMKSVCVLHLFSNKMVRSFRDVRQEEISLMIEKIRISSSLRINLSEILVNLTNNVICRVALGRKYGGKTDFKDLMKRLTRLLGEFSVGSYVSWLAWIDWIRGLDGQLIKISNDLDEFLERVVQDHVDGDGHKNDFVDFLLTIEREKSVGFEIDRLSIKAIILDVFVGDMDTTYTLLEWAMTELLCHHECLDRLQEEVRMVCKDKSGVSEDDLQDMKYLKAVIKETLRLHPPLPLMVPHESTHDVKLRDYHIPAGTHVMINAWAIGREAATWGPDAEEFRPERHLNSYVDYRGQDTELVPFGAGRRICPAISFAVVLDEVVLANLVHQFDWTLPEESTEYQTDVAESTGMAVHRMFPLFAMTT
What are the official names of this protein?
Cytochrome P450 71A24.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FDHD_BORPA
Sequence: MDRLHTSSADWPDHLATQVVRVRGGVLQAAGQSDHVAEETPVALEFNGISHATMLVTPTHLDDFALGFALTEGIVGGMADVRGVELETRCDGIVVQVEIATSCEVRLKERRRAMAGRTGCGLCGVETLPEVVRDVAPAADSDALPVHNVLRAMQSLRSRQTLHDATGATHAAGWADASGEVVLAREDVGRHNALDKLIGALARQGIAPLPGMAVVSSRASFEMVQKTASAGIPILAAVSAPTALAIRLARQTNVTLLGFVRNTDATIYSHPQRIAA
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF85_ARATH
Sequence: MVASHRLLTLMVFALLTIPMISGLISDKCTEGCKSTIGCNTRCMMRGGGYCESAKIHGAVKIFCCCNNYSNSPISSPVIN
What are the official names of this protein?
Defensin-like protein 85.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: RURE_ALCBS
Sequence: MHPIVIVGTGLAGFNTVKEFRKLDKETPIVMLTADDGRNYSKPMLSAGFSKGKTADDLCMATPEKVAEQLNVDVRTGVHVAGIDATNKRVLLPDDHLDYSKLVLALGADTWTPPLEGDAVGEVFSVNDLMDYGKFRAAVEGKKTVTILGGGLIGCEFANDLSNGGFKVSLVEPMGRCLPLLLPEQASEAVGRGLADLGVQFHFGPLAKAVHHGDNGQLVTELSDGSQLESDVVLSAIGLRPRISLAKEAGLDTNRGILTDKSLRTSAEHIYALGDCAEVQGHVLPYVLPLMASARALAKTLAGETTEVSYGVMPVTIKTPACPVVVCPAAEGSEGAWEVEAEGNTVQALFRSKDGSLLGYALTGEAVKEKMKLNKELPAIMP
What is the function of this protein?
Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
What are the official names of this protein?
Rubredoxin-NAD(+) reductase, RdxR.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLB_ANASK
Sequence: MIVRRALALAALALAASPALAAQERPTIVVGSPDFRPLPIAVAAFQGEGDAGVAATQTAEVVRADLVLSGLFDVLDPRGFLADPSEGFAAPSIRFARWADVGADGLAKARVRRGPAGLEGELHLYEVRAGREVLVKLLRVDGADARSLAHRMADEIVRYYTREPGIFATRIAAIRRGRGTWELVTQDMDGGNQQVLLSERSILMSPAWRPDGREILVTSYRSGRPELWAYRFSDRAFRPLGRHRNAFGGVYSPDGSRIAFTVSEGNVTDLWVMSADGVGARKLTSDPAIDVSPTWSPDGRRIAFVSDRSGTPQIYVMGADGSGARRLTFQGNYNQTPQWSPRGDLIAFTARDERKVFDVFVVSPDSGAINRITQDQGRTNEEPSWAPNGRLMIFRTDRNGGIQLVVSDARGDRQTPVTSGKTDLAAPAWGPLAP
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PLSX_GEOUR
Sequence: MRVAVDAMGGDNAPVVEVEGAVAAAGEFGIPVTLVGDTDRVNQELAKYNCKGLDITVKHASEVVGMHDSASDAVRKKKDSSIRVAFDLVKNDEAVAVVSAGNSGATMAAGMFVLKRLKGIDRPAIAQIFPTLRGKTLVLDVGGNVDCKPLHLVQFAIMGEVYARFVMGVDNPRIGLLSNGEEESKGNDLTRETSALLKNTSLDYFGYVEGRDIFNGIVDVVVCDGFVGNVVLKLSEGLAEAVGKMLKDEIKQSLLSKIGYLLSRKAFVNFKKKVDYSEYGGAPLLGIDGVGMICHGGSNAKAIKNAIRFAHEYAQKGVNQRMAEKLQENYPLYMQQLEMLKVQAAG
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: GPA1_DICDI
Sequence: MGNICGKPELGSPEEIKANQHINSLLKQARSKLEGEIKLLLLGAGESGKSTIAKQMKIIHLNGFNDEEKSSYKTIIYNNTVGSMRVLVNAAEELKIGISENNKEAASRISNDLGDHFNGVLTAELAQDIKALWADPGIQNTFQRSSEFQLNDSAAYYFDSIDRISQPLYLPSENDVLRSRTKTTGIIETVFEIQNSTFRMVDVGGQRSERKKWMHCFQEVTAVIFCVALSEYDLKLYEDDTTNRMQESLKLFKEICNTKWFANTAMILFLNKRDIFSEKITKTPITVCFKEYDGPQTYEGCSEFIKQQFINQNENPKKSIYPHLTCATDTNNILVVFNAVKDIVLNLTLGEAGMIL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-1 subunit, G alpha-1.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: GYRA_CAMFE
Sequence: MEENIFSSNQDIDAIDVEDSIKASYLDYSMSVIIGRALPDARDGLKPVHRRILYAMNDLGVGSRSPYKKSARIVGDVIGKYHPHGDTAVYDALVRMAQNFSMRVPAVDGQGNFGSVDGDGAAAMRYTEARMTVLAEELLRDLDKDTVDFIPNYDDSLSEPDVLPARVPNLLLNGSSGIAVGMATNIPPHSLDELVNGLLTLLDDKEVGLEDIMTHIKGPDFPTGGIIFGKKGIIEAYKTGRGRIKLRAKTHIEKKPNKDVIVVDELPYQVNKAKLHADIADLVKEKLIDGISEVRDESDRDGIRLVIELKRDAMSEIVLNNLFKSTQMEVTFGVIMLAINNKEPKVFSLLELLKLFLNHRKTVIIRRTIFELQKARARAHILEGLKIALDNIDAVINLIKTSADTNSARDGLMAKFGLSELQSNAILDMRLSKLTGLEREKLEAELKEILELIEKLDAILKSETLIENIIRDELLEIKSKFKCPRITDIVDDYDDIDVEDLIPNENMVVTITHRGYIKRVPSKSYEKQKRGGKGKVAVTTYDDDFIESFFTCMSHDTLMFVTDRGQLYWLKVYKIPEGSRTAKGKAVVNLISLQADEKIKAIIPTTDFDESKSLAFFTKNGIVKRTNLSEFKNIRSIGVKAINLDDNDELVTVVIANSEPDESYDDSFEDGEGVSNLQTISEDNSENSLESGKMLFAVTKKGMCIKFALNKVRQIGRVSRGVTAIRFKENLDEVVGAVVIENDSQEILSVSQKGIGKRTTADEYRLQSRGGKGVICMKLTPKTKDLVGVVMVDEEMDLMALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVDGDEVVSIARCPKEESDDDDIVADDTQEQDME
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARD8_PONAB
Sequence: MGIPTSSVSEEQESSEGQDSGDICSEENQIVSSYASKVCFEIEQDYKNRQFLGPEGNVDVELIDKSTNTYSVRFPTAGWYLWPATGLGFLVRDVVTLTIGFGSWNQHLALDLQHHEQWLVGGPLFDITAEPEEAVAEIHLPHFISLQAGEVDVSWFLIAHFKNEGMVLEHPARVEPFYAVLEKPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKMIDDEEDRFCGVRLQTSPPVEPLNFGARYIVSNSAHLEIIPTELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITEKRHETLVWKTVVKPVDIQLGAASAPPAFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQAKTRQSKNDTLLTMVEKKGDRALELLFRSISERDPYLVSYLRQQSL
What is the function of this protein?
Constitutes the active part of the CARD8 inflammasome.  In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, N-terminus), preventing activation of the CARD8 inflammasome.  In response to pathogen-associated signals, the N-terminal part of CARD8 is degraded by the proteasome, releasing this form, which polymerizes to form the CARD8 inflammasome complex: the CARD8 inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis.
What are the official names of this protein?
Caspase recruitment domain-containing protein 8.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Caspase recruitment domain-containing protein 8, C-terminus]: Inflammasome.
Protein: NS1_I69A0
Sequence: MDSNTVSSFQVDCFLWHVRKQVVDQELGDAPFLDRLRRDQKSLRGRGSTLGLNIEAATRVGKQIVERILKEESDEALKMTMASAPASRYLTDMTIEELSRNWFMLMPKQKVEGPLCIRIDQAIMDKNIMLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTIEDVKNAIGVLIGGLEWNDNTVRVSKNLQRFAWRSSNENGRHPLTPKQKR
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: RAPZ_ECO8A
Sequence: MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPDLARTLADREISAAVSIDVRNMPESPEIFEQAMSNLPDAFSPQLLFLDADRNTLIRRYSDTRRLHPLSSKNLSLESAIDKESDLLEPLRSRADLIVDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVAAFLDRHTEVHNFIYQTRSYLELWLPMLETNNRSYLTVAIGCTGGKHRSVYIAEQLADYFRSRGKNVQSRHRTLEKRKP
What is the function of this protein?
Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ.  When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E.  Consequently, GlmZ is inactivated and unable to activate GlmS synthesis.  Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
What are the official names of this protein?
RNase adapter protein RapZ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family. RapZ subfamily.
Protein: PACN2_CHICK
Sequence: MSGSYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCNDLMNCIHERARIEKVYAQQLTEWAKRWKQLVEKGPQYGTVERAWCAFMSEAEKVSELHLEVKGSLMNEDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAYHAACKEEKLAISRETNSKADPALNPEQLKKLQDKVERSKQDVLKTKAKYEKSLKELDNATPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKNIYRELEQNIKTADAVEDLRWFRANQGPGMSMNWPQFEDDEWSADLNRTLSRREKKKASDGVTLTGINQTGDQVSQPNKHSSVSSYEKNQSYPTDWSDEESNNPFSSTDAKGDTNPFDEDTSPVMEVRVRALYDYEGQEQDELSFKAGDELTKMENEDEQGWCKGRLDNGQVGLYPANYVEPIQ
What is the function of this protein?
Regulates the morphogenesis and endocytosis of caveolae (By similarity).  Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds.  Plays a role in intracellular vesicle-mediated transport.  Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
What are the official names of this protein?
Protein kinase C and casein kinase substrate in neurons protein 2, Focal adhesion protein of 52 kDa, FAP52.
What is the protein family that this protein belongs to?
Belongs to the PACSIN family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae.
Protein: ORC5_PLAF7
Sequence: MYKIKNNESDINSDDCNETAQECIYGFSSPKKSRKESPIFVQNNDDTCSSNNIYEKKTCSNTSASSVKKYDKKEQSLCSDINNYNKVNIEGLKINERNYDRINNSEEETNINDDNNDDNNGDYDDDNNSDDDDDNDDNNNNDDNNNDDDEDVDDFEDIKENDEYKDPTYSDIYKEAKKCNIRCENIMNSSVNKKNLEEINESDPLNSSDNSMTSSSEESCSEESDKESDKESDKDGNLYDEELNEIIEEGYFKELIPAIPHDILQAYISCLKICGFERQVQLHRLINLLGDLRDPISVIQILGLPGMGKTKVVKNFIKLTNVPFAYVNCLMAVYQSGRSAKNVIYHTILKDLSINLLNEFNEYKKINNITNYSYDPTKLVPNHVSNTDNFFSILHKLLSFKPEDILNNKRTTENIRSPSNSNNNKKKKKEQNDSTGKNSKEECNNNEDDDDDNNKNNFNNNNSNNVRFNSNTNYYKDKLYDRSVVFILDNIRYLVRTHPDLFYALTRIHEYIKGPYNDVTKANKTTRGLCIILINRSPLPDEIFDGLPQPPTVWFDSYTSEMCKNILYRLYNSMCFESLLTYNDKDLKIYYVKHNKNEFLIKRNDVILENDVIYDIWCRYVDYIINVSYKDYKSDFHELLFICSHMWPLFIKPILDGVLEPIVENMNALQRNIDTHIRVATYNHSSHFTFELIDSVFLNENNLKNKIDLSFYSKILLVGAYLASRNLPLTDKRFFNATVKGGAFTLPKKRKGKNKNESILTLLSKSIPKNFTFIRWLCLTDCLLVCFFDEQLILNSLICQQINTLIQLGFISFSSPNNLSCLVRNSLMNGVQWSGYCGSALLNTTTNFSSLTNNIFCETNNSMTYESLDPYTKLVIQVPEETIRNISKEMKIPLDELII
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.
What are the official names of this protein?
Origin recognition complex subunit 5, PfORC5.
What is the protein family that this protein belongs to?
Belongs to the ORC5 family.
What are the subcellular locations of this protein?
Nucleus. Note=During early-to mid replicating trophozoite stages, colocalizes with PCNA1 and ORC1 to distinct nuclear foci which probably are DNA replication origin sites (PubMed:18554328). Dissociates from PCNA1 during the late schizont stage (PubMed:18554328).
Protein: PGK2_METMP
Sequence: MTFDDNIRILVKDKEYDMPFSKGLLARSLTAAGMKPSASYTLARDIERELNEQNVLKISKDELRRRVYYTLINRDYEAIAEKYLLWRRILKKHSIIILVGGSSGVGTSTIAFELASRLGIPSVIGTDSIREVMRRSISKDLVPMLYESSYTAWTALRKSSWEEQDSKEMHLLGFERHVEPVLLGIESIIDRSLTEGTSVIIEGTHIVPGLMAEKYQEMPNVIFLNLTLSSEETHKKRFIARAKVSDRPLERYLENFEIIKEINQYIVEKSKENNLPVIENVSISDTVQKCLEIVTERFSNLNDEPIIDSDFY
What is the function of this protein?
Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate.  Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.
What are the official names of this protein?
2-phosphoglycerate kinase, 2PGK.
What is the protein family that this protein belongs to?
Belongs to the 2-phosphoglycerate kinase family.
Protein: PYRE_SYNY3
Sequence: MTDLTLAALKTAPLAQVRQYLLHLLATHAYKEGDFILSSGQPSTYYINGKLVTLRAEGALAIGRLLLTELPDQVEAVAGLTLGADPIVSAVSTVSAYEEKPVVALIIRKEAKGHGTKAYIEGPELAPGTKVVVLEDVVTTGKSAMLAVERLRNAGYQVDTVISLVDRQQGGREFYQSQGLTFQALFTIGDIQQVYRQK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: TXF1A_SCOAL
Sequence: MKFHIIFCLLAALMMTSAFAEVTVEPLRHSNKNPTESECKNACADAYAKGDQSRIPEAHNFRDYYCNCHITVQ
What are the official names of this protein?
U-scoloptoxin(15)-Sa1a, U-SLPTX(15)-Sa1a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-15 family.
What are the subcellular locations of this protein?
Secreted.