PharMolix/UniProtQA huggingface dataset:
Protein: NFUA_PSEA7
Sequence: MSAITITEAAQAYLAELLEKQSTPGIGIRIFITQPGTQYAETCIAYCKPGEEKVEDTAIALKDFTAWIDAVSEPFLEDAVVDYATDRMGGQLTIKAPNAKVPMVNEDSPITERINYYLQTEINPGLASHGGQVSLVDVVEDNIAVLRFGGGCQGCGMVDMTLKDGVEKTLIERIPELKGVRDVTDHSNKENAYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: OFP1_ARATH
Sequence: MGNNYRFKLSELIPNAWFYKLRDMSKSKKKNLQSQPNSTTSKKKHHAVPTPTSTTPLSPRPPRRPSHSSKAPPSHPPRKSSGNRLRHRATVDSKSSTTSGDSTTTETGSFSPDFRSDQVLLPDESLTGSWHSPCSSKLSKTATFTPPPELELRPIITKTAATARKTAVNSPAGVRLRMRSPRISVSSSARRSGSSARRSRAVVKASVDPKRDFKESMEEMIAENKIRATKDLEELLACYLCLNSDEYHAIIINVFKQIWLDLNLPPPHSK
What is the function of this protein?
Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.  Controls the subcellular localization of the homeodomain protein BLH1.  Plays a role in the regulation of cell elongation by controlling the expression of GA20OX1, a gene that encodes a key enzyme in gibberellin biosynthesis.  May play a role in double-stranded DNA repair through the DNA non-homologous end joining (NHEJ) pathway along with KU70 and KU80 protein complex.  Possesses DNA-binding activity towards double-stranded and single-stranded DNA in vitro.
What are the official names of this protein?
Transcription repressor OFP1, Ovate family protein 1, AtOFP1.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCSH_BOVIN
Sequence: MALRAVRSVRAAVGGLRAISAPSAPCLPRPWGLRAGAVRELRTGPALLSVRKFTEKHEWVTTENGVGTVGISNFAQEALGDVVYCSLPEVGTKLNKQEEFGALESVKAASELYSPLSGEVTEINKALAENPGLVNKSCYEDGWLIKMTFSNPSELDELMSEEAYEKYIKSIEE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
What are the official names of this protein?
Glycine cleavage system H protein, mitochondrial, Lipoic acid-containing protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NUOI_BURCH
Sequence: MTAIQHFFKTFFLTELLKGLALTGRYTFKRKFTVQFPEEKTPISPRFRGLHALRRYENGEERCIACKLCEAVCPALAITIESETRADNTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETQILEYHGEKRGDLYFTKEMLLAVGDRYEKDIAAAKAADAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TONB_SALTY
Sequence: MTLDLPRRFPWPTLLSVGIHGAVVAGLLYTSVHQVIELPAPAQPITVTMVSPADLEPPQAVQPPPEPVVEPEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPKPVKKVEEQPKREVKPAAPRPASPFENSAPVRPTSSTASATSKPAVSVPTGPRALSRNQPQYPARAQALRIEGRVKVKFDVTSAGRVENVQILSAQPANMFEREVKNAMRKWRYEAGKPGSGLVVNIIFRLNGTAQIE
What is the function of this protein?
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc. ).  In the absence of TonB these receptors bind their substrates but do not carry out active transport.  TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection.  It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.
What are the official names of this protein?
Protein TonB.
What is the protein family that this protein belongs to?
Belongs to the TonB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: MRAZ_PARXL
Sequence: MFQGASALTLDAKGRMSIPSRYRDALQTQAEGRVTITRHPDGCLLLFPRPEWEIFRDKVDKLPMNATWWKRIFLGNAMDVDMDGAGRVLVSPELRTAGGLAKEVTLLGMGRHFELWDAQTYTAKEQAAMAEGMPDALKDFTF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: END8_SALPC
Sequence: MPEGPEIRRAADNLEAAIKGKPLTDVWFAFAQLKPYESQLTGQLVTRIETRGKALLTHFSNGLTLYSHNQLYGVWRVIDTGEIPQTTRILRVRLQTADKTILLYSASDIEMLTAEQLTTHPFLQRVGPDVLNARLTPEEVKARLLSPRFRNRQFSGLLLDQAFLAGLGNYLRVEILWQVGLTGQHKAKDLNEAQLNALSHVLLDIPRLSYTTRGQADENKHHGALFRFKVFHRDGEACERCGGIIEKTTLSSRPFYWCPHCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RS17_LISMH
Sequence: MADRNQRKVYTGRVVSDKMDKTITVVVETYKKHGLYGKRVKYSKKFKAHDENNIAKTGDVVRISETRPLSATKHFRLLEVVEEAVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: 3L21_NAJAC
Sequence: IRCFITPDVTSQACPDGQNICYTKTWCDNFCGMRGKRVDLGCAATCPTVKPGVDIKCCSTDNCNPFPTRERS
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Long neurotoxin 1, Toxin III.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PPAC_STRR6
Sequence: MSKILVFGHQNPDSDAIGSSVAFAYLAKEAYGLDTEAVALGTPNEETAFVLNYFGVEAPRVITSAKAEGAEQVILTDHNEFQQSVSDIAEVEVYGVVDHHRVANFETASPLYMRLEPVGSASSIVYRMFKEHGVAVPKEIAGLMLSGLISDTLLLKSPTTHPTDKIIAPELAELAGVNLEEYGLAMLKAGTNLASKSAEELIDIDAKTFELNGNNVRVAQVNTVDIAEVLERQAEIEAAMQAANESNGYSDFVLMITDIVNSNSEILALGANMDKVEAAFNFKLENNHAFLAGAVSRKKQVVPQLTESFNA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADA_NEIM0
Sequence: MQTAARRSFDYDMPLIQTPTSACQIRQAWAKVADTPDRETADRLKDEIKALLKEKNAVLVAHYYVDPLIQDLALETGGCVGDSLEMARFGAEHEAGTLVVAGVRFMGESAKILCPEKTVLMPDLEAECSLDLGCPEEAFSAFCDQHPDRTVVVYANTSAAVKARADWVVTSSVALEIVSYLKSRGEKLIWGPDRHLGDYIRRETGADMLLWQGSCIVHNEFKGQELAALKAEHPDAVVLVHPESPQSVIELGDVVGSTSKLLKAAVSRPEKKFIVATDLGILHEMQKQAPDKEFIAAPTAGNGGSCKSCAFCPWMAMNSLGGIKYALTSGRNEILLDRKLGEAAKLPLQRMLDFAAGLKRGDVFNGMGPA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP61_METCA
Sequence: MATEAHDAGGATGYIVHHLTPLSSGEGFWTLHVDTLFFSVFLGAVFLFFFRKAAEQATAGVPGPFQNFVEMIVEFVDTQVKDSFHGRNALIAPLALSIFAWVFLMNAMDLLPVDLLPDVGKAIGLEYLRVVPSTDLNATFGMSISVFFLIIFYSLKVKGPGHFAMEFLFHPFSHWALVPFNLLLNTVEYLAKPVSLGLRLFGNMYAGELIFILIALLPWWVQPALSFPWAVFHILIITLQAFIFMVLTIVYLSLAHESH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a 1, ATP synthase F0 sector subunit a 1, F-ATPase subunit 6 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FKBPL_METTH
Sequence: MAVNKGDFIKIEFTGKVKETGEVFDTTYEEVAREAGLGIKKIFGPIPVVVGGGHLIKGLDEAVIGMEEGEEKHVEIEPEDAFGNRDPKLVQLIPMGEFKRQGIKPYPGMTLTVEGHEGRVLNVSGGRVRVDFNHELAGKTLEYDLKVKEIITDDAEKVKSMIQLHYPSQNMDIDKTEVKIEDGKVIIHMDEMTRFDNRSYMDVTLARFRIARDIWENIEGVEKVEFADVFEKRDMEAEEKEEEVEDAGED
What is the function of this protein?
Catalyzes the cis-trans isomerization of peptidyl prolyl bonds and accelerates protein folding.  Also exhibits chaperone-like activity (PubMed:10824098).  In vitro, can use oligopeptides such as N-succinyl-Ala-Leu-Pro-Phe-p-nitroanilide and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrates.  The PPIase activity is much lower than those of other FKBPs reported against oligopeptidyl substrates.  As a chaperone, protects green fluorescent protein (GFP) and rhodanese from thermal denaturation or aggregation, and suppresses the aggregation of chemically unfolded rhodanese and elevates the yield of its refolding (PubMed:10824098).
What are the official names of this protein?
Long-type peptidyl-prolyl cis-trans isomerase, Long-type PPIase, FKBP-type peptidyl-prolyl cis-trans isomerase, FKBP-type PPIase, Long type FKBP, MbFK, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
Protein: COAD_BURPS
Sequence: MVVAVYPGTFDPLTRGHEDLVRRASSIFDTLVVGVADSRAKKPFFSLEERLKIANEVLGHYPNVKVMGFTGLLKDFVRANDARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVEKWLTEKVAAMAQGPSA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_ECOL6
Sequence: MSNTPIELKGSSFTLSVVHLHEAEPKVIHQALEDKIAQAPAFLKHAPVVLNVSALEAPVNWSAMHKAVSATGLRVIGVSGCKDAQLKAEIEKMGLPILTEGKEKAPRPAPAPQAPAQNTTPVTKTRLIDTPVRSGQRIYAPQCDLIVTSHVSAGAELIADGNIHVYGMMRGRALAGASGDRETQIFCTNLMAELVSIAGEYWLSDQIPAEFYGKAARLQLVENALTVQPLN
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: GAL83_YEAST
Sequence: MAGDNPENKDASMLDVSDAASNTTINGKHSADSTNEASLAYTFSQMNVDNPNELEPQHPLRHKSSLIFNDDDDDEIPPYSNHAENGSGETFDSDDDIDASSSSSIDSNEGDIHDADMTGNTLQKMDYQPSQQPDSLQNQGFQQQQEQQQGTVEGKKGRAMMFPVDITWQQGGNKVYVTGSFTGWRKMIGLVPVPGQPGLMHVKLQLPPGTHRFRFIVDNELRFSDYLPTATDQMGNFVNYMEVSAPPDWGNEPQQHLAEKKANHVDDSKLSKRPMSARSRIALEIEKEPDDMGDGYTRFHDETPAKPNLEYTQDIPAVFTDPNVMEQYYLTLDQQQNNHQNMAWLTPPQLPPHLENVILNSYSNAQTDNTSGALPIPNHVILNHLATSSIKHNTLCVASIVRYKQKYVTQILYTPLQ
What is the function of this protein?
Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation.  Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex.  Promotes the relocalization of the SNF1 kinase complex to the nucleus upon shift to nonfermentable carbon sources.
What are the official names of this protein?
SNF1 protein kinase subunit beta-3, Glucose repression protein GAL83, Protein SPM1.
What is the protein family that this protein belongs to?
Belongs to the 5'-AMP-activated protein kinase beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Resides in the cytosol during growth on fermentable carbon sources and relocalizes rapidly to the nucleus in response to carbon stress.
Protein: BH010_ARATH
Sequence: MEEERESLYEEMGCFDPNTPAEVTVESSFSQAEPPPPPPQVLVAGSTSNSNCSVEVEELSEFHLSPQDCPQASSTPLQFHINPPPPPPPPCDQLHNNLIHQMASHQQQHSNWDNGYQDFVNLGPNSATTPDLLSLLHLPRCSLPPNHHPSSMLPTSFSDIMSSSSAAAVMYDPLFHLNFPMQPRDQNQLRNGSCLLGVEDQIQMDANGGMNVLYFEGANNNNGGFENEILEFNNGVTRKGRGSRKSRTSPTERERRVHFNDRFFDLKNLIPNPTKIDRASIVGEAIDYIKELLRTIEEFKMLVEKKRCGRFRSKKRARVGEGGGGEDQEEEEDTVNYKPQSEVDQSCFNKNNNNSLRCSWLKRKSKVTEVDVRIIDDEVTIKLVQKKKINCLLFTTKVLDQLQLDLHHVAGGQIGEHYSFLFNTKICEGSCVYASGIADTLMEVVEKQYMEAVPSNGY
What are the official names of this protein?
Transcription factor bHLH10, Basic helix-loop-helix protein 10, AtbHLH10, bHLH 10, Transcription factor EN 23, bHLH transcription factor bHLH010.
What are the subcellular locations of this protein?
Nucleus.
Protein: SEM11_ARATH
Sequence: MAAEPKAATAEVVKMDLFEDDDEFEEFEINEDWLEKEEVKEVSQQWEDDWDDDDVNDDFSRQLRKELENGTDKK
What is the function of this protein?
Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis.
What are the official names of this protein?
Protein DELETION OF SUV3 SUPPRESSOR 1(I), AtDSS1(I), Probable 26S proteasome complex subunit sem1-1.
What is the protein family that this protein belongs to?
Belongs to the DSS1/SEM1 family.
Protein: UPP_EXIS2
Sequence: MSKVHVFDHPLIQHKMTIMRKVETGTKQFRELVDEVASLMAYELTRDLPLTDVEIETPVTKTTQKMIEGKKLGIVPILRAGLGMVDGMLRMMPNVKVGHIGLYRDPETLEPTEYYLKLPTDVAERDFVVVDPMLATGGSAADAISSLKKQGAQSIKLACLCAAPEGVKRIQEEHPDVDIYLAALDEKLNDHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: TATA_PSEAB
Sequence: MGIFDWKHWIVILIVVVLVFGTKRLKNLGSDVGEAIKGFRKAVNTEEDDKKDQPAAQPAQPLNQPHTIDAQAQKVEEPARKD
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LTO1_HUMAN
Sequence: MAGSQDIFDAIVMADERFHGEGYREGYEEGSSLGVMEGRQHGTLHGAKIGSEIGCYQGFAFAWKCLLHSCTTEKDSRKMKVLESLIGMIQKFPYDDPTYDKLHEDLDKIRGKFKQFCSLLNVQPDFKISAEGSGLSF
What is the function of this protein?
The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403).  May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452).  May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674).
What are the official names of this protein?
Protein LTO1 homolog, Oral cancer-overexpressed protein 1, Tumor-amplified and overexpressed sequence 1.
What is the protein family that this protein belongs to?
Belongs to the LTO1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GDF8_MELGA
Sequence: MQKLAVYVYIYLFMQILVHPVALDGSSQPTENAEKDGLCNACTWRQNTKSSRIEAIKIQILSKLRLEQAPNISRDVIKQLLPKAPPLQELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLVQMEGKPKCCFFKFSSKIQYNKVVKAQLWIYLRQVQKPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKAFDENGRDLAVTFPGPGEDGLNPFLEVRVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
What is the function of this protein?
Acts specifically as a negative regulator of skeletal muscle growth.
What are the official names of this protein?
Growth/differentiation factor 8, GDF-8, Myostatin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS24_ARCFU
Sequence: MIDLEVYVEKERHNPLLRRREVYCRLSFEGKTPSRKEVRGKIAGLMNAEPERVVVDYIKTEFGKTEAKCYVKIYDTVEDLQKIEEEHIIERNKVEEQAEEAEEAEAGAAE
What are the official names of this protein?
30S ribosomal protein S24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: ADD_SALTI
Sequence: MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHREKITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDSEKRALREKVAAA
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: MUTS2_STAHJ
Sequence: MRQKTLDVLEFDKIKSFVASETISDLGREKVSKMSPATDFETVEFQMNETDEISQIYNKHRLPSLSGLAKISPLIHRANIGGVLNVTELNLVKRLIQVQNQFKTFYNQLLEEDEQVVKYPILNDKMNQLPILSDLFQEINEKCDTHDLYDSASYELQGIRSKISSTNQRIRQNLDRIVKSQANQKKLSDAIITVRNDRNVIPVKAEYRQDFKGIVHDQSASGQTLYIEPSSIVEMNNQISRLRNDEAVERERILTELTGMVAAEADGCLIAESVMGQIDFLTAKARYARSIKGTKPTFYKDRTVYLPNAYHPLLNKDTVVANTIEFVDDIETVIITGPNTGGKTVTLKTLGLIIIMAQSGLLIPTLDGSQLSVFENVYCDIGDEQSIEQSLSTFSSHMKNIVEILQETDKNSLVLFDELGAGTDPSEGAALAMSILDHVREIGSLVMATTHYPELKAYSYNREGVMNASVEFDVNTLSPTYKLLMGVPGRSNAFDISRKLGLSLGIINKAKTMIGTDEQEINSMIESLEKNSKRVDEQRIELDRLLKEARKTHDDLEHQYEQYKSYEKKLMDEAKEKANQRVKSATKEADSILKELRTLRDQKGADVKEHELIDKKKQLDDQYEAKSLKQNVQKQKYDEIHAGDEVKVLSYGQKGEVLELVSEEEAVVQMGIIKMKLPIEDLEKTKKKKEKPSKMVTRQNRQTIKTELHLRGYRYEEAVSELDQYIDQAVLSNYEQVYIIHGKGTGALQKAVQNHLNKHKSVKSYRGGMPSEGGFGVTVAELK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: GLNR_STRCO
Sequence: MSSLLLLTNALQPSTEVLPALGLLLHNVRVAPAEGPALVDTPGADVILVDGRRDLPQIRSLCQLLRSTGLSCPLVLIVTEGGLAAVTADWGIDDVLLDTAGPAEVEARLRLATGRQQLGGDDSPMEIRNGDLSVDEATYSAKLKGRVLDLTFKEFELLKYLAQHPGRVFTRAQLLQEVWGYDYFGGTRTVDVHVRRLRAKLGPEHESLIGTVRNVGYRFVTPEKPEKGEKSDKSEKAERAEKAERAETPGKAAAETNEAAGARSSKV
What is the function of this protein?
Activates the transcription of the glnA gene.
What are the official names of this protein?
Transcriptional regulatory protein GlnR.
Protein: NOD1_HUMAN
Sequence: MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVVVNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSLACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAYARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF
What is the function of this protein?
Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses (PubMed:19043560, PubMed:22672233, PubMed:27099311).  Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the receptor interacting protein-2/RIPK2.  RIPK2 subsequently recruits the kinase TAK1 to activate NF-kappa-B and MAPK signaling pathways (PubMed:10880512).  Regulates also antiviral response elicited by dsRNA and the expression of RLR pathway members by targeting IFIH1 and TRAF3 to modulate the formation of IFIH1-MAVS and TRAF3-MAVS complexes leading to increased transcription of type I IFNs (PubMed:32169843).  Besides recognizing pathogens, participates in surveillance of cellular homeostasis through sensing and binding to the cytosolic metabolite sphingosine-1-phosphate and then initating inflammation process (PubMed:33942347).  In addition, plays a role in insulin trafficking in beta cells in a cell-autonomous manner.  Mechanistically, upon recognizing cognate ligands, NOD1 and RIPK2 localize to insulin vesicles where they recruit RAB1A to direct insulin trafficking through the cytoplasm (By similarity).
What are the official names of this protein?
Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
Protein: SYS_SHEPC
Sequence: MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQAARNAISKSIGQAKARGEDVDAIMAQVGDLGSQLDAKKLELAAVLEEVNAIAMSMPNLPDESAPIGADETQNVEVRRWGTPRSFDFPIKDHIDLGEGLNGLDFKSAVKITGSRFIVMKGQIARLNRALGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPLTNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSMAALETLTNHAETVLQRLGLPYRTVVLCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAILENYQNADGSVTIPEALRSYMGGLTQIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.