PharMolix/UniProtQA huggingface dataset:
Protein: CARB_LYSSC
Sequence: MPKRTDIETILVIGSGPIVIGQAAEFDYAGTQACLSLKEEGYRVILINSNPATIMTDTEIADKVYIEPISLDFVSRILRKERPDAILPTLGGQTGLNMAIELDKSGILDELGIEILGTKLDAIHKAEDRDLFRNLMYELGAPVPESDIIHSLDEAKRFVVKIGYPVIVRPAFTLGGTGGGICYNDQDLEEIVTSGLKYSPVTQCLLEKSIAGYKEIEYEVMRDAVDNAIVVCNMENVDPVGIHTGDSIVVAPTQTLSDRENQMLRNISLDIIRALKIEGGCNVQLALDPYSFNYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEIKNPVTGSTYACFEPALDYIVAKIPRWPFDKFESAKRNLGTQMKATGEVMALGRTFEEAMLKAVRSLETGQVHLELKHAEDNSDSWIEKRIRKAGDERLFFIGEALRRGVTIEQIHEWSAIDLFFLNKFKNIVDMEQTLADHKNDKEVLRTAKRLGFADKKIAELWDTTEEAIYAYRKEQGIIPVYKMVDTCAAEFESETPYFYGTYEEENESIKSEKPSVVVLGSGPIRIGQGVEFDYATVHSVWAIQEAGYEAIIINSNPETVSTDFSISDKLYFEPLTIEDVMHIIDLEQPIGVVVQFGGQTAINLADKLAANGVKILGTSLEDIDRAENRDKFEQALRDLNIPQPQGETAVSTVEALAIGERLGFPVLVRPSYVLGGRAMEIVYNQEELQHYMENAVEASPDHPVLVDRYLTGQEIEVDAICDGEHVLIPGIMEHIERAGVHSGDSISVYPPQKLTQYQKDTLVDYTTRLAKGLGIVGLMNIQYVISQGEVYVIEVNPRSSRTVPFLSKITNIPMANIATKAILGKSIVEQGYPTGLAPEQKGVFVKVPVFSFAKLRRVDITLGPEMKSTGEVMGKDATLEKALYKGLVAAGMEIRTEGTVLFTVSDKDKEEAIALAKRFSTVGYRIVATEGTAKAFEAAGVRTDVVGKIGAKGQTLIDLIQNGEAQLVVNTLTKGKQPARDGFRIRRESVENGVPCLTSLDTAEAMVRVIESMTFTAEEMPKAEVVH
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: FADB_KLEP7
Sequence: MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGHALDVLEKQSDLKGLLLRSEKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTISAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRLPRLLGADSALEIIAAGKDVGADQALKIGLVDGVVAAEKLRDGALAILRQAMNGDLDWKAKRQPKLEPLKLSKIEAAMSFTIAKGMVAQTAGKHYPAPITAVKTIEAAARLGREEALVLENKSFVPLAHTNEARALVGIFLNDQYVKAKAKKLTKDVETPKHAAVLGAGIMGGGIAYQSAWKGVPVVMKDISDKSLTLGMTEAAKLLNKQLERGKIDGLKLAGVISTIQPTLEYSGFDRVDVVVEAVVENPKVKKAVLAETESKVRPDTVLASNTSTIPISELASVLQRPENFCGMHFFNPVHRMPLVEVIRGEKTSDNTIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKDYRDAIDALFDANRFGQKNGLGFWRYKDDSKGKPKKEEDAAVDSLLADVSQPKRDFSDEEIIARMMIPMVNEVVRCLEEGIIASPAEADMALVYGLGFPPFHGGAFRWLDTIGSAKYLDMAQQYQHLGPLYEVPAGLRDKARHNEAYYPQVEPARPVGALKTA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: Y990_VIBPA
Sequence: MEMSNAQRLILSNQYNLMSQLDPNNAAKYKRLQTIVERGYELQMRELNKDFGCLSEAECREIIDIMEMYHAMQESNNMLDAEERSKVDQRRLQFLGFDIATEAQQVHYVRFLVDSEGLYPQFDKADHHFNSQMPMLDKYRRMLQTWRNCPRQYHLCENELAQIFSA
What are the official names of this protein?
UPF0304 protein VP0990.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: PYRH_HYDCU
Sequence: MSLKYARVLLKFSGEALMGQGQFGLDSNTLRQVVLEVKALRDLGVEVGLVVGGGNIFRGAQIEGAGIQRTTGDHMGMMATVINALALRDVIEDMGMSSVVYSAMAIEGVSHGFNANHVKKGMAEGQVAIFAAGTGSPFFTTDTAAALRGIEIDADIVLKATKVDGIYTADPAKDSSAQRLAELTYDDVIQKNLQVMDMTAFVLCRDHKMPIRVFDMFKKDAVIRIVKGEDEGTLVH
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GABBP_PSEAE
Sequence: MFKSLHQYAHVFSRLSLFGLAFAAAAQAQSQSLTVISFGGATKAAQEQAYFKPFERSGGGQVVAGEYNGEMAKVKAMVDVGKVSWDVVEVESPELLRGCDEGLFERLDPARFGDPAQFVPGTFSECGVATYVWSMVMAYDSTKLARAPQSWADFWNVREFPGKRGLRKGAKYTLEVALLADGVKAEDLYKVLATPEGVSRAFAKLDQLKPNIQWWEAGAQPPQWLAAGDVVMSAAYNGRIAAAQKEGVKLAIVWPGSLYDPEYWAVVKGTPNKALAEKFIAFASQPQTQKVFSEQIPYGPVHKGTLALLPKTVQEALPTAPANLEGARAVDAEFWVDHGEELEQRFNAWAAR
What is the function of this protein?
Binds specifically gamma-aminobutyric acid (GABA) with nanomolar affinity.  Does not bind structurally related compounds such as 4-aminovaleric acid, spermidine, histamine and butyric acid.
What are the official names of this protein?
Gamma-aminobutyric acid-binding protein, GABA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TULP_DROPS
Sequence: MCKLPFSKSRMRQLMEAYIRQKRASPGMVQASDLQISRPMSGMRSNSRELHAYDGPMQFISSPLNPDQILTNGSPVGGTVAMNSTRNHSNNMRTLSTISQEADLIEEISSHELEDEESSPVTVIEQQQTAPHSANSTHSQRPSTTRQPSFNDTLDEDDYTNRNIAGAAPVRPVGLASSPYKEAGLDGSSMETSNGAGGESEGDVIGNIDQFVMQPAPQGVLYKCRITRDRKGMDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYIVSCDPTDLSRSADGFCGKLRSNVFGTSFTVFDSGNKDSTDSPRLDLAVIIYDTNILGFKGPRNMTVILPGMTEDDQRVKISSADPKQTGILDLYKMKNMDNIVELHNKTPVWNDETQSYVLNFHGRVTQASVKNFQLVHDSDPEYIVMQFGRTSEDVFTMDYRYPLCAMQAFAIALSSFDGKIACE
What are the official names of this protein?
Protein king tubby.
What is the protein family that this protein belongs to?
Belongs to the TUB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PROA_PSEAB
Sequence: MTESVLDYMSRLGRDARAASRLLARAATAQKNRALLAAADALDAARAELSHANEQDLAAGRANGLEPAMLDRLALTPARIDDMIEGLRQVATLPDPIGEIRDMRYVPSGIQIGKMRVPLGVVGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNQAIARCIQQGLAEAGLPAAAVQVVETTDRAAVGALISMPEYVDVIVPRGGKGLIERISREAKVPVIKHLDGICHVYIDVAADLDKAIRVADNAKTQRYAPCNTMETLLVHAGIAERALPPLATIYREKGVELRGDAATRALLGADVLEATEEDWRTEYNAPILSIRIVDGLDAAIEHINTYGSQHTDAIITENFSDARRFLAEVDSASVMVNASTRFADGFEYGLGAEIGISTDKLHARGPVGLEGLTSEKYVVFGDGHVRT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_RICAH
Sequence: MTELKIKTAKVEKHLAKEPLKPVLKTPTQKIDSSGKFYATGKRKNAVARVWIKVGKGKIVVNKKTIDQYFPSETYVKTILRPFVLTNTIDQYDVICTVRGGGVSGQKGAILHGISKALDKSVPDFHTILRKGGLLTRDSRVVERKKYGQRKARKKTQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: SYCY1_PONPY
Sequence: MALPYHIFLFTVLLPSFTLTAPPPCRCMTSSSPYQEFLWRMHHPGNIDAPSYRSFSKGTPTFTAHTHMPRNCYNSATLCMHGNTHYWTGKMINPSCPGGLGVTVCWTYFTHTGMSDGGGVQDEAREKHVKEVISQLTQVHSTSSPYKGLDLSKLHETLRTHTRLVSLFNTTLTGLHEVSAQNPTNCWMCLPLAFRPYVSIPVPEQWNNFSTEINTTSVLVGPLVSNLEITHTSNLTCVKFSNTTNTTNSQCIRWVTPPTQVVCLPSGIFFVCGTSAYRCLNGSSESMCFLSFLVPPMTIYTEQDLYNYVVSKPRNKRVPILPFVMAAGVLGALGTGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSIAAVVLQNRRALDLLTAERGGTCLFLGEECCYYVNQSGIVTEKVKEIRDRIQRRAEELRNIGPWGLFSQWMPWILPFLGPLAAIILLLLFGPCIFNLLVNFVSSRIEAVKLQMEPKMQSKTKIYHRPLDWPASPRSDVNDIKGTPPEEISTAQPLLRPNSAGSS
What is the function of this protein?
Endogenous envelope proteins may have kept, lost or modified their original function during evolution.  Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.  The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein.  The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of membranes (By similarity).
What are the official names of this protein?
Syncytin-1, ERV-W1 provirus ancestral Env polyprotein, ERVWE1 envelope protein, Endogenous retrovirus group W member 1, Envelope polyprotein, Syncytin.
What is the protein family that this protein belongs to?
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
What are the subcellular locations of this protein?
[Surface protein]: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Syncytin-1]: Virion.
Protein: P2C71_ORYSJ
Sequence: MAELPLAAGLLDLRPCKLAPPPPPPLPVSPSPRHHRRPHSTATACRAAPDLHSSTELADGSIVFRFARPRDDDDEEQQQRRADAVAPEAAAVVESGLDGDAAAAAEPEARDGGGEGEVTATATGLDAEEVVASGGAEATATSGLEDAGEEASDGSTARDSDTDVDTESSASTAADDDQPAEFAVPPPPAEEVCNKVDWEKDTSEVKNTDRMVPVASSTLVLASGAAILPHPSKAATGGEDAYFIACDGWFGVADGVGQWSFEGINAGLYARELMDGCKKFIMENQGAADIKPEQVLSKAADEAHSPGSSTVLVAHFDGQFLNASNIGDSGFLVIRNGEVYQKSKPMVYGFNFPLQIEKGDNPLKLVQNYTIELEDGDVIVTASDGLFDNVYEQEVATMVSKSLQADLKPTEIAEHLAAKAQEVGRSAAGSTPFSDAALAVGYLGFSGGKLDDIAVVVSIVRKSEI
What are the official names of this protein?
Probable protein phosphatase 2C 71, OsPP2C71.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: RL23A_TOBAC
Sequence: MAPAKADPSKKSDPKAQAAKVAKAVKSGSTLKKKSQKIRTKVTFHRPKTLKKDRNPKYPRISAPGRNKLDQYGILKYPLTTESAMKKIEDNNTLVFIVDIKADKKKIKDAVKKMYDIQTKKVNTLIRPDGTKKAYVRLTPDYDALDVANKIGII
What is the function of this protein?
This protein binds to a specific region on the 26S rRNA.
What are the official names of this protein?
60S ribosomal protein L23a, L25.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: MINE_PROM5
Sequence: MTLRDLINKLLGRETSSANTARERLQLVLAHDRVDMSSLTTDLLDKMRKEILDVVAKYVEIDFEEVAVSLETEDRMTALVANLPIKRTLTGEIEFKKNHDNPKKK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: CBID_CLOK5
Sequence: MFDLYINCGGKKLRCGYTTGSCAAAAAKAAAKMLYSQENLEHISINTPKNVELDLHIESVKKGSDYVECCVIKDGGDDPDVTNGIEIWARAEKSEKEYTLKAGIGIGIVKGEGLYVKKGDFAINPVPRIMIEKEVRKVLPQGKGVTITIFVPEGEKIAKKTFNPRLNIVGGISILGTTGIVVPMSEEALKESVKLEISQKVASGYKDLILLFGNMGEDKARELGMDIKKSVIMSNYVGFALECCVENKIEKILIVGHIGKLSKIAAGCFNTHSRVCDVRLEVMALELALMGADKKIVEAVYNEKTTEGAVKIISEEYKDIYERIGYKIKKRIEDFTYGALKAEVIMYCMASGILWDGRSKIDENN
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: LFTR_SHEWM
Sequence: MNSLSYLNHELEQFPSPEFALTDPNGLLAVGGDLQPKRLLNAYYEGIFPWFNIDDPILWWSPDPRAVFVPGNMKTSRSLLKHLKKQPWRYSINHAFSQVIEGCAAPRSSQDGTWITPEIQDAYLKLHELGKAHSIEVWHQDELIGGLYGLATGQVFCGESMFHTQTNASKAAMLLLHQHLLKQGFKLIDAQVMNPHLASLGATALRRKDFINLLKRFRDLPVAADAWARSEVSLEL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAIE_SALEP
Sequence: MSYYAFEGLIPVVHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLILEAGSNLQDGCIMHGYCDTDTIVHENGHIGHGAILHGCVVGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFQGEARQLLVGSPARVLRQVTDQELHWKRLNTKEYQDLAIRCRTGLSETKPLTQVEENRPRLKGTTDVKPKSAQ
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: MED11_DANRE
Sequence: MANDRLRALEDVEKEIALVLQSAGTIVLELSKEKANASLLDRQLNQFQTSINRVESELSSQIRYLTQVATGQPHEGSTYSARKDCQMALNRAEYARVKLGELGRTCEMMLDPQT
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 11, Mediator complex subunit 11.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 11 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTGDS_URSAR
Sequence: MAALHTLWMGLVLLGVLGVLQTQAQVQVSLQPNFQQDKFLGRWFTSGLASNSSWFREKKKVLSMCVSVVAPSADGGLNLTSTFLRKEQCETRTLLLRPAGTPGCYSYTSPHWGSTHDVWVAMTDYDEYALLYTTGTKGLGQDFHMATLYSRTQTPRAEIKEKFTTFAKTQGFTEDAIVFLPQTDKCMEEHK
What is the function of this protein?
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation.  Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes.  Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter.  Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier.  It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity).  Involved in PLA2G3-dependent maturation of mast cells.  PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
What are the official names of this protein?
Prostaglandin-H2 D-isomerase, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Protein: HBB_SQUAC
Sequence: VHWTGEEKALVNAVWTKTDHQAVVAKALERLFVVYPWTKTYFVKFNGKFHASDSTVQTHAGKVVSALTVAYNHIDDVKPHFVELSKKHYEELHVDPENFKLLANCLEVELGHALHKEFTPEVQAAWSKFSNVVVDALSKGYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PHAM_XANAG
Sequence: MQAPSVHQHVAFTEEIGDLPDGSSYMIRVPENWNGVLIRDLDLVSGTSNSNAARYETMLKEGFAVAGTARHPLRQWQYDPAHEIENLNHVLDTFEENYGSPERVIQYGCSGGAHVSLAVAEDFSDRVDGSVALAAHTPVWIMNSFLDGWFSLQSLIGEYYVEAGHGPLSDLAITKLPNDGSSNSSGHGMEGDLPAAWRNAFTAANATPEGRARMALAFALGQWSPWLADNTPQPDLDDPEAIADSVYESAMRLAGSPGGEARIMFENAARGQQLSWNDDIDYADFWENSNPAMKSAVQELYDTAGLDLQSDIETVNSQPRIEASQYALDYWNTPGRNVIGDPEVPVLRLHMIGDYQIPYSLVQGYSDLISENNNDDLYRTAFVQSTGHCNFTAAESSAAIEVMMQRLDTGEWPSTEPDDLNAIAEASNTGTEARFMALDGWEIPEYNRTWKPE
What is the function of this protein?
Catalyzes the removal of the phthalyl group from phthalyl amides generating phthalate and an amine.  The enzyme has a broad substrate specificity and hydrolyzes phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines; substitutions allowed on the phthalyl group include 6-F, 6-NH(2), 3-OH, and a nitrogen in the aromatic ring ortho to the carboxy group attached to the amine.
What are the official names of this protein?
o-phthalyl amidase.
Protein: PITX3_DANRE
Sequence: MDFNLLTDSEARSPALSLSDSGTPQHDPGCKGQDNSDTEKSHQNHTDESNPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGAQFNGLMQPYDDMYSGYSYNNWATKSLASSPLSAKSFPFFNSMNVSPLSSQPMFSPPSSIPSMNMASSMVPSAVAGVPGSGLNNLGNLNNLNSPTLNSAAVSAAACPYATTAGPYMYRDTCNSSLASLRLKAKQHANFAYPAVQNPVSNLSPCQYAVDRPV
What is the function of this protein?
Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity).  Required for lens and retinal development and for pituitary pre-placode formation and cell specification.
What are the official names of this protein?
Pituitary homeobox 3, Bicoid-like homeodomain transcription factor Pitx3, Homeobox protein PITX3, Paired-like homeodomain transcription factor 3.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PIGN_MOUSE
Sequence: MLLFFALGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTLYELDEDGNSRAPFIRNVIIHEGSWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTWGAGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGILPVGYLNNTGLFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLDILRKARSYIKQEKFDEVVSLCEELIDLALRGLSYYHTYDRLFLGINVAVGFVGWMSYTSLLIIKSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYYVYCLLPVPIWYAVLREHEVIQDLVESLLTFPRSHFVAYLLVFTLGIEVLVLSFFYRYMLTAGLIVFAGWPFLTQLWTRAKITFLSWAFFSLLLAVFPLMPVVGRKPNLSLVMGAGFLVLLLSLAVVTTLGKRNIKLVKGELLVLLLQMLSTVLSMYVVYSTHHSLLKKEGLPLMNQIVSWATLASSLVAPLLSSTALSQRLASILLSLMSTYLLLSTGYEALFPLVLSCLMFVWIQVEQETLQQPGVSCKQKLTSIQFTCDTDIAQFRQLCPDDIRRAFFLVFFLLTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQITTQLSSKGLFLVVLIISDIMALHFFFLVKDSGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLTTKKLQLCGKPKSHLM
What is the function of this protein?
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.  May act as suppressor of replication stress and chromosome missegregation.
What are the official names of this protein?
GPI ethanolamine phosphate transferase 1, Phosphatidylinositol-glycan biosynthesis class N protein, PIG-N.
What is the protein family that this protein belongs to?
Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
Protein: RNAS1_BISBI
Sequence: KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: FOLC_BUCBP
Sequence: MINKKLARSFSLYEWLYYLDHFMLDNIDPTLNRVFYVAKKLGVLKSKAFVFIVGGTNGKGSTCHVLENLLLNSGYRVGLYTSPHLMRYTERVRINGFELEHLYHISAFNDVKYFQNDVLLTRFEFITLSALILFKSYNLDIIILEVGLGGRLDATNILSADVSVITNIDIDHSKILGVNRSSISVEKSGIFRKNKIAIVADNNFPKVAQYLAKKKKVRLRIVNIDWIYKKIEFEWSFCSSKITWLHLPLPRNVSLDSVATALSAVSESGIKINQKVFRSCISEITLCGRFETISYNPIIILDVAHNPHSARYLFKKMSSFKKNGNIFAVVGILKEKNIKDIVSPLIPIVDYWYCITLLTHRSATSSEIIKYLPNHNSQISKNMTVALEKIFDKVTNNDIVLIFGSFITVCEANKFLANKVKNFKLL
What is the function of this protein?
Functions in two distinct reactions of the de novo folate biosynthetic pathway.  Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu).  Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.
What are the official names of this protein?
Dihydrofolate synthase/folylpolyglutamate synthase, DHFS / FPGS, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, Folylpolyglutamate synthetase, Tetrahydrofolylpolyglutamate synthase.
What is the protein family that this protein belongs to?
Belongs to the folylpolyglutamate synthase family.
Protein: DUT_LEPBL
Sequence: MKIPIKKLRSNAELPVLQTKHAAGYDVHACLDSNLILEPNKVTLVPTGLSFEIPQEYHFEIRPRSGFSTKNQILIPNSPGTIDSDYRGELMIPLFNLGNIPFVIEHGMRIAQLLIRETHYTNWELVSEFTDTTERGTGGFGSTGH
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: CENPA_XENTR
Sequence: MRPGSTPASRRKSRPPRRVSPPLPTTSTRSPGRPSAPEQRKAPRATPKKRFRPGTRALMEIRKYQKSTELLIRKAPFSRLVREVCMTYACGLNYSWQSMALMALQEASEAFLVRLFEDSYLCSLHAKRVTLYVQDIQLARRIRGVTEGLG
What is the function of this protein?
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes.  Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore.  The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3.  May serve as an epigenetic mark that propagates centromere identity through replication and cell division.  Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.
What are the official names of this protein?
Histone H3-like centromeric protein A, Centromere protein A, CENP-A.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height.