PharMolix/UniProtQA huggingface dataset:
Protein: SPT5H_HUMAN
Sequence: MSDSEDSNFSEEEDSERSSDGEEAEVDEERRSAAGSEKEEEPEDEEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQNNIHVKDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRGGFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLKILNLRFLGKLLEA
What is the function of this protein?
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II.  DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A.  DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter.  Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex.  DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II.  TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme.  Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites.  DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat.  DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
What are the official names of this protein?
Transcription elongation factor SPT5, hSPT5, DRB sensitivity-inducing factor 160 kDa subunit, DSIF p160, DRB sensitivity-inducing factor large subunit, DSIF large subunit, Tat-cotransactivator 1 protein, Tat-CT1 protein.
What is the protein family that this protein belongs to?
Belongs to the SPT5 family.
Protein: GLCU_STAAR
Sequence: MQFLDFLIALLPALFWGSVVLINVFVGGGPYNQIRGTTLGALIVGLGLLITGFAKFNNPTVIIVGLISGALWAFGQANQLKSISLIGVSNTMPVSTGMQLVGTTLFSVIFLGEWSSMTQIIFGLIAMILLVTGVALTSLKAKNERQSDNPEFKKAMGILIVSTVGYVGFVVLGDIFGVGGTDALFFQSVGMAIGGFILSMNHKTSLKSTALNLLPGVIWGIGNLFMFYSQPKVGVATSFSLSQLLVIVSTLGGIFILGERKDRRQMTGIWVGIIIIVIAAIILGNLK
What is the function of this protein?
Involved in the uptake of glucose.
What are the official names of this protein?
Probable glucose uptake protein GlcU.
What is the protein family that this protein belongs to?
Belongs to the GRP transporter (TC 2.A.7.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFTU_PARD8
Sequence: MAKEKFDRSKPHVNIGTIGHVDHGKTTLTAAITTVLAKKGLSELRSFDSIDNAPEEKERGITINTSHVEYQTANRHYAHVDCPGHADYVKNMVTGAAQMDGAIIVVAATDGPMPQTREHILLARQVNVPRLVVFMNKCDMVDDEEMLELVEMEMRELLSFYQFDGDNTPIIRGSALGALNGDAQWEDKVMELMEACDTWIPLPPREIDKPFLMPVEDVFSITGRGTVATGRIETGIVKVGEEVQIIGLGAAGKKSVVTGVEMFRKLLDQGEAGDNVGLLLRGIDKNEIKRGMVICHPGQVKEHSKFKAEVYILKKEEGGRHTPFHNKYRPQFYIRTLDVTGEITLPEGTEMVMPGDNVTIEVELIYPVACSVGLRFAIREGGRTVGAGQITELEN
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_BACLD
Sequence: MKKLWGGRFQKTPEKWVDEFGASIHFDKTLVKEDIAGSLAHASMLEKCGILTEAEAVKIKEGLTSLLHKAEKNELDFSVDCEDIHLNLEKMLIDEIGPLGGKLHTARSRNDQVATDMHLYLKGHTEHIIELITAFQHVLIEKAEEHVETILPGYTHLQRAQPISFAHHLLAYFWMLERDKERYHDSFKRINKSPLGCGALAGTTFPIDREYSADLLGFDSIYENSLDGVSDRDFILEFLSASSILMMHLSRFSEEIILWCSQEFKFIELDDTYATGSSMMPQKKNPDMAELIRGKTGRVYGDLIGLLTIMKGLPLAYNKDLQEDKEGMFDTVKTVEGSLEIFAGMIKTMTVNKNMMKKATEQDFSNATELADYLAKKGMPFREAHEVVGRLVFTCIEKGIYLSGLPFEEFKKASGLFEEDVYIVLDPHHAVEKRMSEGGTGFKKVTEAIQKAKQCLNNF
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GOSR1_YEAST
Sequence: MSSQPSFVTIRGKAISLETQTESLLSKYSTFAQTTSSEQTGQEKKIDKQLEGILGQRQDVIDSLTQICDSNPAISASKLSQLHRHKEILQDHWKSFRNIRSSIQQERNRLNLLFSVKNDIANSTTDAPAPIGDADEYIQNETRRIDQSNNVVDRLISQAWETRSQFHSQSNVLNTANNKVLQTLQRIPGVNQLIMKINTRRKKNAFVLATITTLCILFLFFTW
What is the function of this protein?
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport.  It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.  Rescues alpha-factor maturation defects.
What are the official names of this protein?
Golgi SNAP receptor complex member 1, Golgi SNARE protein 1, Protein transport protein GOS1.
What is the protein family that this protein belongs to?
Belongs to the GOSR1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Punctate localization pattern. Localization affected by loss of SVP26, a membrane protein, and is shifted to the ER.
Protein: XPT_LISMC
Sequence: MKLLEEFIQEKGTVLPGNVLKVDAFLNHQIDPVLMQAMGNEFAKRFQDLGITKIVTIESSGIAPAVFAGLALSVPVVFARKKKSVTLTDNLFTSTVYSYTKKESNDISVSKQFLTVDDTILVIDDFLANGQAALGLLEIAEHAGAKVAGIGIVIEKSFQQGRELLNKTGIPVYSLARIASLENEEILFLEEE
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSUB3_RHOJR
Sequence: MTAAEAPLPPLAPRERTATTAAERRTGSPLAVSLSGVRKSFGDKTVLSGIDLEITRGEFVVLLGPSGTGKTTLLRLLSGLEPPDGGDVLVPRQRTVVYQEPRLIPSKRVLANVSVGQKRAQLTRDNARRALAEVNLADKERAWPATLSGGEAQRVALARALVREPELLLLDEPFAALDALTRLQMQDLVGDLVARHRPAVLLVTHDVDEAVRLADRVLILDNGGFAVDVDIDLPRPRDRNDPEALRYRATFLAQLGVGRPSSTRQDIS
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB 3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS7_ARCFU
Sequence: MKYGFTKEELLVFGKYDPSEVQISDPALESYICLEPKYVPHNHGRHANVPFAKQKVFIVERLINKVMRKGHNTGKKILAYNIVKEAFEIIEKKTKKNPIQVLVDAIINAGPREEVVRLKYGGIAVPKAVDTSSSRRVDIALRNIAEGARRAAFKSKRSIAQCLADEIIAAANNESRSFAVAKKEEVERVAKSAR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: VG29_BPML5
Sequence: MIPSQESHNPNDPRQHVMWALRNLPMIAGVGAITHPGYLADWSEHLWKCGFRHVDWLRELADEDGNIHVSQLPDQEIKFQQPFRGQRSDYNNAARWVGKDDPDPEPVRIPDIRKLTDQENRAMIAQYERDGWIKDGSPGPAIAEVVE
What are the official names of this protein?
Gene 29 protein, Gp29.
Protein: RS14_RHOPS
Sequence: MAKKSSIEKNNRRRKMTKNAAPKRARLKAIIADKDLPMEERFAATLKLAEMPRNSSATRIRNRCEITGRSRSVYRLNKLSRIAIRDLGSKGLVPGLVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: MIEAP_XENLA
Sequence: MADILRRLTNSERCRLLQDKLDDWYKDYHINSCDSNLNVCCELLELNSKVQGQLFKILSVTAQEGGQYAGVETIKSRFLPWLGTCFSTASPGSFSENSFVTLNESMERKLSTSHERELNEVESKLSSTRIELNSVRQELLETQMDLEDTKTKSANTLLATEEEILQLRAELRAAREKLELRSLDSIDEYERQIRLLKDEISILSSESSILKSRLSRSRSPSPIRHSSRSSSPFARSESPTSAKLTSASRQARLISRFNDIFANDRLDAQTLLRRYIQDLDMVQRIIFIATVESFHSAKMAFRQFRLRVCKSLSPSHMGPESLEDAVIDYIVGNLDLYDVQSSVNEVISAMNVNPKISFPPEVDFILISGFIQEVCRVAFTMQTLDPPLDIAFTVDGELFTDSKYRRTYDSEHTAPLVYYHVWPALMENDNVIVKGEAVTKRGALWNSIRSRSRSASPLRSHSDSPGHNLTRSRSPSPRRSGTPRF
What is the function of this protein?
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage.  Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen.  Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity).
What are the official names of this protein?
Mitochondria-eating protein, Spermatogenesis-associated protein 18.
What is the protein family that this protein belongs to?
Belongs to the MIEAP family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress.
Protein: PYRF_CANBO
Sequence: MSETLKTQPYSKRAEVHPSPVARRLFNLMETKKTNLCASVDLTTTKEILDLLEKVGPYICLVKTHIDIVSDFSYEGTIVPLLALAKKYNFMIFEDRKFADIGNTVKSQYKGGVYQIAKWSDITNAHGVTGSGIVTGLKQAAEEVTDEPRGLLMLAELSSKGAIAHGKYTEETVEIAKTDKDFVIGFIAQNQMGGSDEGFDWIIMTPGVGLDDKGDALGQQYRTVSEVMSTGTDIIIVGRGLFGKGRDPSVEGERYMKAGWNAYLARTNQL
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase, Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family.
Protein: FENR2_BACC1
Sequence: MKVAENQKVYDITIIGGGPTGLFTAFYGGMRQASVKIIESLPQLGGQLSALYPEKYIYDVAGFPKVRAQELVDNLKEQMKKFDPTVCLEEAVDTLEKQADGIFKLVTNKQTHYSKSVIITAGNGAFQPRRLELEGTAKYEKKNLHYFVDDMNKFAGKRVVVFGGGDSAVDWTMMLEPIADKVTIVHRRDKFRAHEHSVESLMNSRAEVSTPYVPVELIGDDKIEQVVLQHVKTEEKIIIDVDDVIVNYGFVSSLGPIKNWGLDIQKNSILVNSKMETNIPGIYAAGDICTYEGKVKLIACGFGEAPTAVNNAKAYFDPNAKLQPMHSSSMF
What are the official names of this protein?
Ferredoxin--NADP reductase 2, FNR 2, Fd-NADP(+) reductase 2.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: URK_ENT38
Sequence: MTDKSHQCVIIGIAGASASGKSLIASTLYRELRDQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLQMIKNGTPIDLPVYSYVDHTRTQDTIHIEPKKVIILEGILLLTDARLREAMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_XANAC
Sequence: MARITVEDCLEVVNNRFELVMMASKRARQLANGVQPLIENADASDKPTVMALREIAARRIDNALIDEVEKAERERAEREALEWAAAEVVADEDMSKNDD
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: METK_TRIEI
Sequence: MSSRYLFTSESVTEGHPDKICDQISDTIIDAILAQDPQSRVAAEVVVNTGLVLITGEITTKAQVNYIELARKKIADIGYVHAENGFSADSCSVLVALDEQSADIAQGVDKAQETRELLSEEELDAVGAGDQGLMFGFACNETPELMPLPISLAHRVCRQLTAVRKTGQLPYLRPDGKSQVTITYEDGRPVGIDTILISTQHTAKIGEITELSDIQAKIKEDLWKYVVEPIFKDAEIKPNSQTRFLVNPTGKFVIGGPQGDCGLTGRKIIIDTYGGYSRHGGGAFSGKDPTKVDRSAAYACRYIAKNIVAADLAEKCEVQISYAIGVAKPVSMMIETFGTSKVDEDKLLEVVKENFELRPAGIIQNFNLRNLPGERGGRFYQDVAAYGHLGRTDLDLPWEQTDKVELLKQAFSPQLLATAS
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_ECOLC
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLEPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEVFLERGYKVVSGGTDNHLFLVDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRVGTPAITRRGFKEAEAKELAGWMCDVLDSINDEAVIERIKGKVLDICARYPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_SHESM
Sequence: MNHKVLLINGPNLNLLGRREPSVYGHQTLADIVATLSEQAQAAGVELEHIQSNAEFELINAIHATDAQMIIINPAAFTHTSVALRDALLGVDIPFFEVHLSNVHAREPFRHHSYLSDKAIGVICGFGAQGYEFALAAAIKRLKA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: PJVK_MOUSE
Sequence: MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRCKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRSNHIVNDVGINVTGSDSIAVKASFGVVTKHEVEVSTLLKEITARKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGREKAIVFPAHTTIAFSVFELFIYLDGAFDICVTSVSKGGFEREETTTFAMFYRLRNILFERNRRVMDAISRSQLYLDDLFSDFYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNLKRETVYGCFQCSVDGVKYVRLHAVPCFDIWHKRMK
What is the function of this protein?
Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage (PubMed:26544938, PubMed:30936319).  Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy) (PubMed:26544938, PubMed:30936319).  Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss (PubMed:30936319).  PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress (PubMed:30936319).  In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation (PubMed:26544938, PubMed:30936319).
What are the official names of this protein?
Pejvakin, Protein sirtaki.
What is the protein family that this protein belongs to?
Belongs to the gasdermin family.
What are the subcellular locations of this protein?
Peroxisome membrane. Cell projection, cilium. Note=Associates with the peroxisomal membrane; it is unclear whether it is embedded or just associated with the peroxisomal membrane (PubMed:26544938). Localizes to ciliary rootlet (PubMed:28209736).
Protein: NRDR_SALG2
Sequence: MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVIKSNDVREPFNEDKLRSGMLRALEKRPVSADDVEMALNHIKSQLRATGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKDFGEEIARLQD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: VE6_HPV44
Sequence: MESANASTSAQSIDQLCKECNIPMHNLQILCVFCRKTLSTAEVYSFAYKQLYVVYRGNFPFAACAICLELQGKVNQFRHFNYAGYAVTVEEETNKSILDVLIRCYLCHKPLCHVEKVRHILDKARFIKLQDTWKGRCFHCWTSCMETILP
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: BIPS3_SORAU
Sequence: MAPVVKNEPQHAKILAIGTANPPNVFHQKDYPDFLFRVTKNEHRTDLREKFDRICEKSRTKKRYLHLTEEMLKANPNIYTYGAPSLNVRQDICNIEVPKLGQEASLKAIKEWGQPISKITHLIFCTASCVDMPGCDFQLIKLLGLDPSVTRTMIYEAGCYAGATVLRMAKDFAENNKGARVLVVCAEITTVFFHGLTDTHLDILVGQALFADGASAVIVGANPEPEIERPLFEIVACRQTILPNSEHGVVANIREMGFNYYLSGDVPKFVGGNVVDFMTKTFEKVDGKNKDWNSLFFSVHPGGPAIVDQVEEKLGLKEGKLRATRHVLSEYGNMGAPTVHFILDEMRNKSIEEGKTTTGEGLEWGVVIGIGPGLTVETAVLRSEFITY
What is the function of this protein?
Type III polyketide synthase involved preferentially in the biosynthesis of 4-hydroxycoumarin from salicoyl-CoA.  Can also use benzoyl-CoA and malonyl-CoA to produce 3,5-dihydroxybiphenyl as a major product and benzoyldiacetic acid lactone as a minor side product.  Can also use m-hydroxybenzoyl-CoA as substrate, producing m-hydroxybenzoyl diacetic acid lactone as a derailment product.  No activity with p-hydroxybenzoyl-CoA, CoA-linked cinnamic acids or acetyl-CoA.
What are the official names of this protein?
4-hydroxycoumarin synthase 2, Biphenyl synthase 3, SaBIS3.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: VP1_SV40
Sequence: MAPTKRKGSCPGAAPKKPKEPVQVPKLVIKGGIEVLGVKTGVDSFTEVECFLNPQMGNPDEHQKGLSKSLAAEKQFTDDSPDKEQLPCYSVARIPLPNINEDLTCGNILMWEAVTVKTEVIGVTAMLNLHSGTQKTHENGAGKPIQGSNFHFFAVGGEPLELQGVLANYRTKYPAQTVTPKNATVDSQQMNTDHKAVLDKDNAYPVECWVPDPSKNENTRYFGTYTGGENVPPVLHITNTATTVLLDEQGVGPLCKADSLYVSAVDICGLFTNTSGTQQWKGLPRYFKITLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMIGMSSQVEEVRVYEDTEELPGDPDMIRYIDEFGQTTTRMQ
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins.  Binds to N-glycolylneuraminic analog of the ganglioside GM1 on the cell surface to provide virion attachment to target cell (PubMed:18353982).  Once attached, the virion is internalized by caveolin-mediated endocytosis and traffics to the endoplasmic reticulum.  Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating (PubMed:17981119).  Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus (PubMed:17981119).  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal.  The assembly takes place in the cell nucleus.  Encapsulates the genomic DNA and participates in rearranging nucleosomes around the viral DNA.  The viral progenies exit the cells by lytic release.
What are the official names of this protein?
Major capsid protein VP1, Major structural protein VP1.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses coat protein VP1 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host endoplasmic reticulum. Note=Following host cell entry, the virion enters into the endoplasmic reticulum through a calveolar- dependent pathway. Then, viral DNA is translocated to the nucleus. Shortly after synthesis, a nuclear localization signal directs VP1 to the cell nucleus where virion assembly occurs.
Protein: CYB_DIPEL
Sequence: MTILRKTHPLMKMVNHAFIDLPTPANISGWWNFGSLLGLCLIIQIASGLFLAMHYTPDTLTAFSSVTHICRDVNYGWLIRYMHANGASLFFICLYLHIGRGIYYGSYSYTETWNIGIILLFLTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLNRFFAFHFILPFIIAATAMVHLLFLHETGSNNPLGIPSDCDKIPFHPYYTTKDFLGMILLLAFFFTIVLFFPDLLGDPDNYSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVIALIMSILVLALLPHIQTSKQRSLMFRPISQFLFWLLVADVLALTWIGGQPVEPPFIIIGQIASLLYFTIILILMPIAGIIENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: WZYE_SHISS
Sequence: MSLLQFSGLFVVWLLCTLFIATLTWFEFRRVRFNFNVFFSLLFLLTFFFGFPLTSVLVFRFDVGVAPPEILLQALLSAGCFYAVYYVTYKTRLRKRVADVPRRPLFTMNRVETNLTWVILMGIALVSVGIFFMHNGFLLFRLNSYSQIFSSEVSGVALKRFFYFFIPAMLVVYFLRQDSKAWLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGMNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYDNIDFQGLAPIVRDFYVFIPSWLWPGRPSMVLNSANYFTWEVLNNHSGLAISPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNREPNRYKAAILHSFCFGAIFNMIVLAREGLDSFVSRVVFFIVVFGACLMIAKLLYWLFESAGLIHKRTKSSLRTQVEG
What is the function of this protein?
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
What are the official names of this protein?
Probable ECA polymerase.
What is the protein family that this protein belongs to?
Belongs to the WzyE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.