PharMolix/UniProtQA huggingface dataset:
Protein: PNP_LARHH
Sequence: MFNKFSKTFQYGRHTVKLETGEIARQASGSVLVSMDDTVVLVAVTVNKDVKPGQDFFPLTVDYYERTYAAGKIPGGFFKREGKQSEKEILTCRLIDRPIRPLFPAGFYHDVQVVATVMSLNPEVDADIPAMIGASAAMVLAGVPFMGPIGAARVGYANGEYILNPTKTELTTSQLDLVVAGTESAVLMVESEAQQLPEAVMLGAVVYGHEQMQAAIKAINELADEVNPVIFEWAPAAEDTELVAQVKALAEADVAAAFKIRQKQARSQALGEAWSKVKAALITEETETLRANHIKSLFKELEANVVRGQILAGEPRIDGRDTRTVRPIAIRTGVLPRAHGSVLFTRGETQALVSTTLGTKQDEQIIDALAGEYTDRFMLHYNFPPYSTGETGRMGPPKRREIGHGRLAKRALIAVLPKQEDFSYSMRVVSEITESNGSSSMASVCGGCLSLMNAGVPLSAHVAGIAMGLILEDNRFAVLTDILGDEDHLGDMDFKVAGTENGVTALQMDIKIQGITKEIMQVALDQAKEGRLHILGIMKSAIDAPQELSTHAPRLYTLRINPDKIRDVIGKGGSVIRALTEETGTSIDIAEDGLITIASVSAEGAEEAKRRIEEITAEVEIGKIYEGTVVKILDKNVGAIVQIMPGRDGLVHISQIANERIANVADHLQEGQQVRVKVLETDERGRIRLSIKAALADAPQV
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOBA_SHEB9
Sequence: MSSQIDAVILAGGMARRMGGDDKGLVELNGEAMIKHTIDRIKPQVKEILINANRNQTRYAEFGFKVISDEHTGFLGPLAGMITAMGQTDADYLLVVPCDCPLLPTDLVPRMLAAIKAEDAEIAVASDGEYEQPVVLLLKPSLRDSMKAFLEAGERKVDFWYAKHHFVVESFSDQPNAFVNVNTPEQKQRLAMEITK
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_BORAP
Sequence: MGQKVHPYSLRVKINKDWKSKWYFDKKLYSTILHEDFLIRLEIMKFLKGIKFDISDIEIIRNNPQKVTVVIVTPRPGSVIGLKGSNLEKIGQLLTKKISKKISIKIKEVKRPELDAQIIANGIAKQVENRVSYRKVLKSALSTSMLKGAQGLKIKIAGRLGGAEIARSFEVKEGRVPLHTLRANIDYGFSEAHTTYGIIGVKVWLFKGEVLGRQTNSDAGQVINKKPFRERGETVKNFDKILNNREKINEKQTRALNKKDGLSKDEASLLNKLSSSFSKERVDSNEQNIGG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PNCB_AGRFC
Sequence: MTKTDIATRVHNHTWKLDPIVRSLIDTDFYKLLMLQMIWKLYPEVDATFSLINRTKTVRLAEEIDEMELREQLDHARTLRLSKKENIWLAGNTFYGRSQIFEPEFLSWLSSYQLPEYELFKRDGQYELNFHGRWMDTTLWEIPALSIINELRSRSAMRSLGYFTLDVLYARAKAKMWEKVERLRELPGLRISDFGTRRRHSFLWQRWCVEALKEGIGPAFTGTSNVLLAMDSDLEAVGTNAHELPMVVAALAQTNEELAAAPYQVLKDWNRLYGGNLLIVLPDAFGTAAFLRNAPEWVADWTGFRPDSAPPIEGGEKIIEWWRKMGRDPRTKMLIFSDGLDVDAIVDTYRHFEGRVRMSFGWGTNLTNDFAGCAPKTIASLKPISIVCKVSDANGRPAVKLSDNPQKATGDPAEVERYLKFFGEEDHKEQKVLV
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: MRAY_GEOTN
Sequence: MPEQIIVIAMAVSFLITVILSPLFIPFLRRLKFGQSIREEGPKSHQKKSGTPTMGGIMILLSIIATTVWVTAKFSVLSAGTYLLLFVTIGYGVLGFLDDMIKVVMKRNLGLTSRQKFIGQLIIAVIFFFVYRQSGFSTALHIPGTDWSFDLGWAYGVLLLFMLVGGSNAVNLTDGLDGLLAGTAAIAFGAYAVLAWNQGQYDVAVFCVAVVGAVLGFLVFNAHPAKVFMGDTGSLALGGAIAAVAVLTKLELLLVVIGGVFVIETLSVIIQVASFKMTGKRVFRMSPLHHHYELVGWSEWRIVVTFWAVGLLFAMLGIYIEVWI
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDXA_BURVG
Sequence: MTAAALQIAITTGEPAGVGPELTVQALQDAARRWPDAQFTVLGDAALLDARAAAVGADRAVLAGGPVSVQHHPLAAPAHAGTLDAANGRYVLALLDAAIDGALAGRYDAIVTAPLQKSTINDAGVPFTGHTEYLAERTHTPRVVMMLAGTGERPLRVALATTHLPLKDVSAALTIDGLVDTLAIIDRDLRRDFGLAAPRILVTGLNPHAGENGYLGREEIDVIAPALARASERGIDARGPYPADTLFQPRYLAGADCVLAMFHDQGLPVLKYATFGEGINVTLGLPIIRTSVDHGTALDLAGTGRADPGSMVAALDTAVTMARHRRAS
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y078_METHJ
Sequence: MPDYLVVLESAWTIRDADSVDDAISIAISEAGKRLNPTAKFVEVEAGILSCPYCEEELPCTLIVARTALVGVKMEMKVYKADSEEHARRIALSTIGKALRDIPLEIIEVEEL
What are the official names of this protein?
UPF0212 protein Mhun_0078.
What is the protein family that this protein belongs to?
Belongs to the UPF0212 family.
Protein: CSRP3_HUMAN
Sequence: MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE
What is the function of this protein?
May play a role in early sarcomere organization.  Overexpression in myotubes negatively regulates myotube differentiation.  By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization.
What are the official names of this protein?
Cysteine and glycine-rich protein 3, Cardiac LIM protein, Cysteine-rich protein 3, CRP3, LIM domain protein, cardiac, Muscle LIM protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere. Note=Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity). SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, myofibril, sarcomere, Z line.
Protein: SQS13_PANGI
Sequence: MGSLGAILKHPDDFYPLLKLKIAARHAEKQIPSEPHWAFCYSMLHKVSRSFGLVIQQLGPQLRDAVCIFYLVLRALDTVEDDTSISTEVKVPIVMAFHCHIYDNDWHFSCGTKEYKVLMDEFHHVSNAFLDLGSSYKEAIEDITMRMGAGMAKFICKEVETIDDYDEYCHYVAGLVGLGLSKLFHASGAEDLATDSLSNSMGLFLQKTNIIRDYLEDINEIPKSRMFWPRQIWSKYVDKLEDLKYEENSAKAVQCLNDMVTDALVHAEDCLKYMSDLRGPAIFRFCAIPQIMAIGTLALCFNNTQVFRGVVKMRRGLTAKVIDQTKTMSDVYGAFFDFSCLLKSKVDNNDPNATKTLSRLEAIQKTCKESGTLSKRKSYIIESESGHNSALIAIIFIILAILYAYLSSNLLLNKQ
What is the function of this protein?
Component of the triterpene saponins (e. g.  ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:27746309, PubMed:29378087).  Catalyzes the biosynthesis of squalene (By similarity).
What are the official names of this protein?
Squalene synthase 13, PgSS13, SQS 13, FPP:FPP farnesyltransferase SS13, Farnesyl-diphosphate farnesyltransferase SS13.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: IQCAL_RAT
Sequence: MSEGTYQRLWEASHATLEEVLEKEPSPLEPVLTRERQSFQYRISVLYLYYLGLLRRFNLAYDQMVQPQKRRLLRRLLDGVAGRVLELKDELVRVDLCETHCLDRVLQELKLTPVDLEVPIPKYFQLEQTSTMKARQQMLAEILARLEPLASQENLRGMSRTEALIIVQCAERARQGRLRATFMREIRKEEERDRRIRENGRQKFSQDQGAIVIQKVWKGYLQRKRIEQDRRMEMEFIGMLPSSSQTTRQNALAQAFVGEESRRTRQVEKEEEFQEAIAKTHESLTETEGPDMKERMKDQIRQWFIECHALTGRFPDYPDEASGGSYLIFADKTPEQVRQELEAQAQENKKKEQEKNKDKVKEKKEKKKKKTKEEKAKKDPEVMFKVLPSKSIPVINAGHEEFTSIWKSRYDNKHPSQSFDSETLREEKRKQVEMEIRVQVDELMRQELRNLRLAVDREETRPLKSPKKKGGKKSGKKKKEKDLTPDRSVDSLFEELVVIGLIKKSLLVTLNDYIGDCLYLGSTLTLANKIPMPSLFDIRQNIALYGVLRLGSHDIHTMAPLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPGNVMGKYPGKNGSQLLMHIVFKVARVFQPSVIWIGNTEKTFYKKIPKEERRMDPKRIKKDLMRATRQLGPGDRVMLIGTTERPQLAEMKGLCRFYERILFIPRPDYASRYVLWKRMIENQGIGVQQTQSLDISALARVSDGYTPGHILQSIQSVLTERRLLQLTKKPLVASEFVVHLAKLDPVYREEEESLKEWFYKTPLGKKNIKFTKDQQEAEEARLAKEKKKKK
What are the official names of this protein?
IQ and AAA domain-containing protein 1-like, Protein IQCA1P1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: ISPD_CHLTE
Sequence: MKTVVIIAASGVGKRMKLDGGRSKQMLEIGGQPVIWHTMKAFQEASTVESVYIATLPDSIPVFKEIAKANGFTKITAIIEGGKERQDSIGNCMKLIEQEIENSGVMPDAILVHDGARPFIQPEEIDDIARLSATHGACVPATKPKDTIKYVGCNPEIFGETLDRSRLLQVQTPQGFAPAKLIEAHRLAGEEQWYATDDAALVERYFPQQAIRIYETGYHNIKITTPEDVFIGEAILAGLKARKSKN
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: Y5109_VIBC1
Sequence: MNLSAKTVVVIAIGAALYGIGGLPMFGIPVFANTTLKPAMAVLALFSVLFGPLVGFLVGFIGHWVTDLFAGWGVWLTWVLGSGIVGLIIGLFPSLTRNRLEKGDFNMKDFALFVVLALLGNVFGYGCSAFLDTILYAEPFTKVFTQLSIIALGNTILIAIVGFFILKSVAKRNKQSRNLTEA
What are the official names of this protein?
UPF0397 protein VIBHAR_05109.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TGB3_PVXCP
Sequence: MEAGAYLNAIIFVLVATIIAVISRGLTRTEPCTIRITGESITVHACHIDSETIKALANLKPLSLERLSFQ
What is the function of this protein?
Plays a role in viral cell-to-cell propagation, by facilitating genome transport to neighboring plant cells through plasmosdesmata.  May induce the formation of granular vesicles derived from the Endoplasmic reticulum, which align on actin filaments (By similarity).
What are the official names of this protein?
Movement protein TGBp3, 7 kDa protein, Triple gene block 3 protein, TGBp3.
What is the protein family that this protein belongs to?
Belongs to the Tymovirales TGBp3 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane.
Protein: RL18_HAES1
Sequence: MDKKSARIRRAARARHMMREQGVIRLVIHRTSRHIYAQVIAPNGSEVLATASTVEKAISEQVKYTGNKDAAAVVGKIVAERALEKGIKSVAFDRSGFKYHGRVQSLADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PA_I61A1
Sequence: MEDFVRQCFNPMIVELAEKTMKEYGENPKIETNKFAAICTHMEVCFMYSDFHFINERGESIIVEPGDSNALLKHRFEIIEGRDRNVAWTVVNSICNTTGVGKPKFLPDLYDYKEDRFIEIGVTRREVHVYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMSREVNARIEPFLKTTPRPLRLPCGPPCFQRSKFLLMDALKLNIEDPSHEGEGIPLYDAVRCMKTFFGWKEPTIVKPHEKGINSNYLLAWKQVLAEIQDIEDEKKIPRIKNMKKTSPLKWALGENMAPEKVDFDDCKDVSDLKQYDSDEPEFRSLASWIQNEFNKACELTDSSWLELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCILEIGDMVLRTAIGQVARPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNCLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYESIEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: RLMH_AGRRK
Sequence: MRIGLFAVGRLKTGPEKDLAARYLDRFAKAGPAIGLELARMTEVAESRASNGETRKREEAVLLQKAHPDGGILILLDERGKALDSEAFAALLGTFRDQGKRDLTIAIGGADGLDPSLYDRADATICLGKMTWPHQLVRILIAEQLYRAVTILSGHPYHRV
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_GEODF
Sequence: MNFSRSADLFKQAQNSIPGGVNSPVRAFKSVGRDPLFIKKASGCKIEDVDGNQFIDFVGSWGPMILGHCHPQVASAVKAAVDSGCSFGAPTELEITLAEMVINAVPSIEMVRMVSSGTEATMSAIRLARGYTGRDKILKFSGCYHGHSDSLLVKAGSGAATFGVPDSPGVPQDFARHTLTADYNSLESVRTLIAENKGQVACIIVEPVAGNMGTVPPREGFLEGLRTLCTQEGIVLIFDEVMSGFRVAYGGAQEVYGVTPDMTTLGKIIGGGLPVGAFGGKKEIMTLLSPSGGVYQAGTLSGNPLAMTAGIETLKLLQAEGFYRNLEEKSSYVAAGIARAAEKAGFPIYSARVGSMFCAFFSKDPVYDWTTAAKCDTEAFAKYFRLMLGEGIYLAPSQYETAFVSIAHATEDLDRTIAAAEKSFRAL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EREMS_GIBF5
Sequence: MIATINGDTKINGKGHPTEVRIPDMFGSIMSATPMVNPHHFKVKAAADAFIADYLKMDKHEATKNRKADFCFCASAMAPHADAEALRTMVDWLNWIFYFDDDFDEGQLDRDPVAAEKEIRHTLAVLEEGAEIPDRELHPLRYLFRTIWDRVKERAYPDVQTQFKITHKRYLDGLLHQVEATRDGNGQPRTEEDYIRMRRRTVGGYPCISLIAYAHNVDLSQEAFEHPSVQECIAVGCDLAWIHNDIVSYKKDVKSGIEHNFITVLKKNGFTTQQAMDRAGELQDECYRRWYLALASMPIWGESIDREVLRYIEACHSFPLGDLLWSFQTGRYLGATEGYKLHETRVLDLSDLEPIAV
What is the function of this protein?
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene eremophilene via a 1,10-cyclization, which requires the abstraction of the pyrophosphate from FPP to yield the (E,E)-germacradienyl cation.  The only accepted substrate is farnesyl diphosphate (FPP).
What are the official names of this protein?
(+)-eremophilene synthase, Sesquiterpene cyclase, Terpene synthase, Type I terpene cyclase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: WDR48_MOUSE
Sequence: MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDVVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLHRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVTPMDEEENEVNHVSGGQESRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETEAMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST
What is the function of this protein?
Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46.  Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself.  Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate.  Also activates deubiquitinating activity of complexes containing USP12.  Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme.  Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination.  Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA).  DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes. Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA.  Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress.
What are the official names of this protein?
WD repeat-containing protein 48, USP1-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR48 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Lysosome. Late endosome. Note=Mainly in cytoplasmic compartments.
Protein: FUMC_HAEDU
Sequence: MEYRIEKDTMGEVKVPADRYWAAQTERSRNNFRIGPEASMPVEIIEAFAYLKKAAAFANAELGALTTEKRDLIAMVCDEILANKLADEFPLVIWQTGSGTQSNMNLNEVIANRAHVLQGGALGEKSIIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEVTIPAIERLQKTFAIKSEAFKDVVKIGRTHLMDATPLTLGQEFSAYAAQLQFGLLALKNTLPHLAQLALGGTAVGTGLNTPKGYDVKVAEYIAQFTQLPFITAENKFEALATHDAIIETHGALKQIAMSLFKIANDIRLLASGPRSGIGEILIPENEPGSSIMPGKVNPTQCEAMTMVAAQVLGNDTTISFAGSQGHFQLNVFKPVMAANFLQSAQLLADVCISFDEHCASGIEPNYPRIQQQLENSLMLVTALNTHIGYENAAKIAKTAHKNGTTLKEEAINLGLVTAEQFDQWVRPQNMVGSLK
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_NATTJ
Sequence: MTKLLSYINTSEDLKHLSTEDLNKLAEELREFLISSISITGGHLAPNLGVVELTLAIHKVFSPIQDKIVWDVGHQSYIHKILTGRKEQFSTLRQFGGLSGFPKPEESRYDAFGTGHSSTSISAALGMAKARDLQGSNEEVLAVIGDGAMTGGMAFEAMNHAGHEQANMTVILNDNEMSIGTNVGALSSYLSRLRTDPKYHRIKEDVEFLLKRIPAIGGKMMKSVERVKDSMKYLMVSGMLFEELGFTYIGPIDGHNIPQLMEVLNNAKDKNGPVLVHVITKKGKGYEPAEKFPDKFHGTGPFEIETGNAPKKAETAPSYSKVFGDTISEIARKNESVVAITAAMKDGTGLTNFAREFPERFFDVGIAEQHAITFAAGLARKGFKPVVAIYSTFLQRAYDQIIHDVCMQDNPVIFAIDRAGIVGGDGETHQGLYDLSYLRSIPNLIVMAPKDEAELQRMLNTAVNINKPVAIRYPRGKGEGVTLWENMTPIPLYKGETIREGSQVAMIGVGKMVPDMLEVADMLKKEGIEPTVFNARFVKPLDESSILEIAQKHEYIYTFEENTELGGFGSQVLECLSKHGLAHKLIDRFCLPDEYIPHGDRSKVLSQYSLHSQELINKILNRLRGEQIEQG
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RS4_STRU0
Sequence: MSRYTGPSWKQSRRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFSYGLGEKQFRNLFVQATKIKEGTLGFNFMILLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVEPGQVISVREKSMKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: CTHL6_BOVIN
Sequence: METQRASLSLGRWSLWLLLLGLALPSASAQALSYREAVLRAVDQFNERSSEANLYRLLELDPPPKEDDENPNIPKPVSFRVKETVCPRTSQQPAEQCDFKENGLVKQCVGTVTLDAVKGKINVTCEELQSVGRFKRFRKKFKKLFKKLSPVIPLLHLG
What is the function of this protein?
Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi.
What are the official names of this protein?
Cathelicidin-6, Antibacterial peptide BMAP-27, Myeloid antibacterial peptide 27.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNZ_STAES
Sequence: MEVTFFGTSAGLPTKERNTQSIALNLEPYSNSIWLFDVGEGTQHQILRHSIKLGKIDHIFITHMHGDHIFGLPGLLTSRSFQGGENKPLTIIGPKGIQNYIETSLQLSESHLNYPITYIEINQQLAYHHNGFTVQAEMLNHGIPSFGYRIEAPIMPGTINVEALRGIGLEPGPKYQEVKLQETFEYKGLIYNSDDFKGKAKPGPIISIFGDTKPCENEYELAKNSDLMIHEATYIEGDKKLANNYHHSHIDDVFNLIKQANVNKSLITHISNRYNIDEVTSIYNELSLDQTSPHFYFVKDFDTFKI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RL10_STRP6
Sequence: MSEAIIAKKAEQVELIAEKMKAAASIVVVDSRGLTVDQDTVLRRSLRESGVEFKVIKNSILTRAAEKAGLDELKDVFVGPSAVAFSNEDVIAPAKVINDFTKTADALEIKGGAIEGAVSSKEEIQALATLPNREGMLSMLLSVLQAPVRNVAYAVKAVAENKEGAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: 235L_IIV6
Sequence: MDICICYFFTILTTISCWNVTSYSKNSDFQYLSSKNFLDQLQIASNKTVIDIGCGNGKITNYISSLVKDGSVIGIDKDSSMIKYAKETYPNVDFKVMDIQNENIDKKYDIVVSFFCLPWIVNKQASFHHISNMMKSGSKLYILAAIMETNHVTLINNLMKKDHWKLFFVNYSSPFDYLNDIQYDIYANQSGIEQKKFKVYNIPYTFKDRQSLHKFNLAILPQLNQLSIEHREIFITELLNDYFSFIGSVNLTINFTIVKFIGCRV
What are the official names of this protein?
Putative methyltransferase 235L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.