PharMolix/UniProtQA huggingface dataset:
Protein: COLI_CAMDR
Sequence: YGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ
What is the function of this protein?
Beta-endorphin and Met-enkephalin are endogenous opiates.
What are the official names of this protein?
Beta-endorphin.
What is the protein family that this protein belongs to?
Belongs to the POMC family.
What are the subcellular locations of this protein?
Secreted.
Protein: PROB_PHEZH
Sequence: MSGLGQARRVVVKVGSALLVGPDGAPHADWLADFAADAARMRARGQQVLVVSSGAVALGRRRLGLARRALTLPEKQAAAAAGQSALMRAWEEAFEPHGAACAQVLLTRDDTEVRRRWLNARATVETLLGLGVVPVINENDTVVTEEIRYGDNDRLAARVAQLVGADVLVLLSDVDGLYTADPRKDPAARHIPRVPRLTPEVEAMAGGANAEGGVGTGGMATKIAAARIAAAGGCATVITLGSRTRPLAAVEGGERATVVEPATTPAAAYKAWIAGSLAPAGALVVDDGAAQAVRRGKSLLAAGVRRVEGRFDKGDAVLVRDEAGREIARGLVRYEAADAERICGLKSEAIEGVLGYTSGPLVHADDLALAAHAEA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3S12_LATCO
Sequence: MKTLLLTLVVVTVVCLDLGYTRRCYNQQSSQPKTTKSCPPGENSCYNKQWRDHRGSITERGCGCPTVKPGIKLRCCESEDCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin II.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: APAG_BRUA1
Sequence: MYSAVTRGIEVTVEPFYLEVQSEPEENRYVWGYRVTIVNNSSETVQLCSRYWQITDANGHVQEVRGSGVVGKQPVLDPGDSYQYSSGCPLTTSSGVMVGRYQMKGEDGAQFEIEIPAFSLDVPEQRRTLN
What are the official names of this protein?
Protein ApaG.
Protein: SN12L_PONAB
Sequence: MQLSEGLAAHGTRRAGKWKRTQVPLLGEECADMDLARKEFLLGNGLAAGKMNISIDLDTNYAELVLNVGRVTLGENNRRKMKDSQLRKQQNENVSRAVCALLNSGGGFIKAEVENEDYSYKKDGIGLDLENSFSNMLPFVPNFLDFMQNGNYFHIFVKSWSLETSGPQIATLSSSLYKRDVTSAKVMNASAALEFLKDMEKTGGRAYLRPESPAKRACVDVQEESNMEALAADFFNRTELNYKEKLTFTESTHVEIKNFATEKLLQRITEILPQYVSAFANTDGGYLFVGLNEDKEIIGFKAEKSYLTKLEEVTKNSIGKLPVHHFCVEKGTINYLCKSLGVYDKGRLCGYVYALRVERFCCAVFAKKPDSWHVKDNRVKQLTEKEWIQFMVDSESVCEELPSPASTSSPVSQSCPLCEYINFKIQPLRYHLPGLSEKITFAPKTLCRNLFSQHEGLKQLICEEMGSVSKGSLIFSRSWSLDLGLQENHKVLCDALLISQDKPPVLYTFHMVQDEEFKGYSTQTAQTLKQKLAKIGGYTKKVCVMTKIFYLSPEGKTSCQYDLNSQVIYPESYYWTTAQTMKDLEKALSNILPKENQIFLFVCLFRFCLFVCLFVFFLR
What are the official names of this protein?
Schlafen family member 12-like.
What is the protein family that this protein belongs to?
Belongs to the Schlafen family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PA2B_HYDSC
Sequence: NLVQFSYVITCANHNRRSSLDYADYGCYCGAGGSGTPVDELDRCCKIHDDCYGEAEKQGCYPKMLMYDYYCGSNGPYCRNVKKKCNRKVCDCDVAAAECFARNAYNNANYNIDTKKRCK
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that has several activities.  It is myotoxic, has weak anticoagulant activity and inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2, svPLA2, Myotoxin, Phosphatidylcholine 2-acylhydrolase, Toxin VI-5, Toxin VI:5b.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CYB_MUSER
Sequence: MTNIRKTHPLTKIINNSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTATAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFLHVGRGLYYGSYMFSETWNIGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIISALAAVHLLFLHETGSNNPSGIPSDSDKIPFHPYYTIKDILGALFLILTLMLLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILVLAIIPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFITIGQLASILYFMILLVLMPIISIIENNMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TPIS_LACLM
Sequence: MSRKPIIAGNWKMNKTLSEAQAFVEAVKNNLPSSDNVESVIGAPALFLAPMAYLRQGSELKLAAENSYFENAGAFTGENSPAAIVDLGIEYIIIGHSERREYFHETDEDINKKAKAIFAAGATPILCCGETLETFEAGKTAEWVSGQIEAGLAGLTAEQVSNLVIAYEPIWAIGTGKTATNEIADETCGVVRSTVEKLYGKEVSEAVRIQYGGSVKPETIEGLMAKENIDGALVGGASLEADSFLALLEMYK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_ARCFU
Sequence: MHLQRLKEELERDIARIAEFKPVVHHITNYVAMNDSANITIAIGASPIMSFAHGEIDELVSIASSLLINIGTLDEYIIQAVMLAVKSAKSKGVPVLLDPVGSGATKLRTSTALSVAEEGVDVIKGNQGEILSLLRKEGVVRGVDSKVTAEAADVKEVARKFGLVVVATGKEDLISDGRSVYVMRNGTEMLGRITASGCMLGSVIASFMAVQKDFLLASLEGLACYNVAGELAAEKSSGTASFRSNLIDEISKITAEKVIERLNLERVV
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: S35A4_DANRE
Sequence: MIAISADESPESSSPALRLRWLFLLLLLVLIYGSHAPLLSLCKTQAQIPFSASSCVLLIETSKLFISFASLLASGSVSTLRISISMTTASPYAVPAVLYAFNNHLVVFMQAYMDPSSFQVLSNLKIASTALLYTSCLGKRLHRRQWFAMGLLVSAGVSHSCFSYDLEGKRETAVYITSWGLLLVLVYCFVSGLAAVYTERVLKSQRLPLSMQNLFLYTFGVVVNLASHLSGGEQKGFFEGYSAVVWVIVAGQVANGLLMSVVMKHGTGITRLFVISSAMLVNAVLSWGILGVQLTGYFLFPVVLIGWAVYLYYT
What is the function of this protein?
Mediates the transport of CDP-ribitol (By similarity).  Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity).
What are the official names of this protein?
Probable UDP-sugar transporter protein SLC35A4, Solute carrier family 35 member A4.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: FIEF_PECCP
Sequence: MNPHYARLVTLAAVSATAVALVLFIMKVFAWWHTGSVSLLASLVDSLVDIAASLVNLLVVRYSLQPADTEHAFGHGKAESLAALAQSMFISGSALFLILTGLQHSLEPQTLHAPEVGMWVTLIALVATLLLVSFQRWVVKRTHSQAVRADMLHYQSDLLMNGAILVALALSWKGITRADSLFALGIGGYILYSALRMGYDAVQSLLDRALPDDEHRAIAEVIVNWPGIRGAHALRTRRSGPTRFIQLHLEMDDALPLVQAHQIADDLEQALLKRFPGADIIIHQDPVSAVPENQRGRLTA
What is the function of this protein?
Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+).  May be involved in zinc and iron detoxification by efflux.
What are the official names of this protein?
Cation-efflux pump FieF.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYFA_KLEP3
Sequence: MSHLAELVASAKAAINEASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKADLEGAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDATRLLRTQTSGVQIRTMENQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDKNISFTNLKGTLHDFLNNFFEEDLQVRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGMERLTMLRYGVTDLRAFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_CLOBK
Sequence: MGLTPMMRQYLEVKESCKDCILFFRLGDFYEMFFEDAKVASKELELVLTGRDCGLEERAPMCGIPYHAANTYIGRLVSAGYKIAICEQLEDPSASKGIVKRGIIKIITPGTYTDSSFLEENKNNYIMSFYLDDNMCAMSFADISTGEFNSTHSNFKEAVVLDEISKFAPREIVLEENIKESFIHTIKERFPNISISKIKEENFDYNIDNNLKEQFNNFNENEYETIVKKSANGLLYYIFHTQKNILSNINKIDYYSIVDYLTIDVNSRRNLEITENLREKTKKGSLLWVLDKTNTAMGGRQLRRWIEQPLINKNPIENRLNAVEELLNNISLQEDLKEDLKSIYDIERIVGKVASKSVNAKELISLKCSIGKVPYIKKYLSNFKSDLFLNMEQCIDTLEDIHKLLDKALLDNPSLSVKEGNIIKEGFNEEVDSLREAKSNGKKWIASLEQKEKEETGIKSLKVSYNKVFGYFIEITKANLNLVPEGRYIRKQTLSNAERYITPELKEMEEKILGAEEKLIDIEYKLFTKIRDFIEENIDRMQKTARIISDIDCLCSLATVALENNYIKPNINAKNEILIEEGRHPVVEKVIPKGEFISNDSLIDTKENQLILITGPNMAGKSTYMRQVALITIMAQIGSFVPAKKANISICDKIFTRIGASDDLAAGKSTFMVEMWEVSNILKNATSKSLVLLDEVGRGTSTYDGLSIAWSVIEYICNNKNLRCKTLFATHYHELTKLEDNIEGVKNYSVSVSELENEIVFLRKIIRGGADQSYGIEVAKLAGLPSPVINRAKEILQHIEGDKEENSLNITPSKEYKSKDYIEASKDTLNTKNNLESEIKHDTLSETNAATIVEDESTKEHLSSNKKQINCRINDEKSIKKEVAVDSFQINFEYIKRDKIIEEIKNIDILNMTPMEGFNKLYDIINKTKDID
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: AMPC_YEREN
Sequence: MMKKSIINTLIFTSIATFPLYTLAQTKLTELQVATIVNNTLTPLLEKQGIPGMAVAVFYDGKPQFFNYGMADIKAGRPVTENTLFELGSVSKTFTGVAGEYAMQTGIMNLNDPVTEYAPELTGSQWKDVKMLHLATYTAGGLPLQLPDSVTDQKSLWQYYQQWQPQWAPGVMRNYSNASIGLFGALAVKRSQLTFENYMKEYVFQPLKLDHTFITIPESMQSNYAWGYKDGQPVRVTLGMLGEEAYGVKSTSQDMVRFMQANMDPESLPAGNDKLKEAIIASQSRYFQAGDMFQGLGWEMYSWPINPQGVIADSGNDIALKPRKVEALVPAQPAVRASWVHKTGATNGFGAYIVFIPEEKVGIVMLANKNYPNPVRVQAAYDILQALR
What is the function of this protein?
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
What are the official names of this protein?
Beta-lactamase, Cephalosporinase.
What is the protein family that this protein belongs to?
Belongs to the class-C beta-lactamase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PRUN1_MOUSE
Sequence: MEDYLQDCRAALQDSRPLHVVLGNEACDLDSMVSALALAFYLTKTSEAEDIFIPVLNIKRSELPLRGDNVFFLQEVKIPEPALIFRDEIDLLALHQAGQLTLILVDHHILPKSDAALEEAVAEVLDHRPIEQKYCPPCHVSVELVGSCATLVTERILQGAPETLDRQTAALLHGTIILDCVNMDTNIGKATPKDSKYVEELEALFPDLPKRKDIFDSLQKAKFDVSGLTTEQMLRKDQKTVYRQGTKVAISAIYMDLKAFLQRTDLFTDLSSFCHDHSYDALVAMTIFFNTQNEPVRQLAIFCPHEALRMTICGILERSTSPPLKLTPIPSTSPNLQAYHQGNTQVSRKKLLPVLQEALSAYLDSAKMASGQSEVAVGMSREQVDKDLDKASNSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKFSAEAVFEKCSQISLSQSARACTSNK
What is the function of this protein?
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate.  Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1.  Plays a role in the regulation of neurogenesis.  Involved in the regulation of microtubule polymerization.
What are the official names of this protein?
Exopolyphosphatase PRUNE1, PRUNEM1.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family. Prune subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell junction, focal adhesion.
Protein: ZAPA_ACTPJ
Sequence: MSANYIEVQIFGQVLRFHCPPDQQENLLASAQRLEERVALLKDQSGIIQLEKVLTIVALNLNYELEQEKQKNANNKAVLESCIHQLDNSLSKLLSGSSVAINQESV
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division (By similarity).
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid- cell.
Protein: TMM19_PONAB
Sequence: MTDLNDNICKRYIKMITNIVILSLIICISLAFWIMSMTASTYYGNLRPISPWRWLFSVVVPVLIISNGLKKKSLDHSGALGGLVVGFILTIANFSFFTSLLMFFLSSSKLTKWKGEMKKRLDSEYKEGGQRNWIQVFCNGAVPTELALLYMIENGPGEIPVDFSKQYSASWMCLSLLAALACSAGDTWASEVGPVLSKSPPRLITTWEKVPVGTNGGVTVVGLVSSLLGGTFVGIAYFLTQLIFVNDLDISAPQWPIIAFGGLAGLLGSIVDSYLGATMQYTGLDESTGMVVNSPTNEAKHIAGKPILDNNAVNLFSSVLIAVLLPTAAWGFWPRG
What are the official names of this protein?
Transmembrane protein 19.
What is the protein family that this protein belongs to?
Belongs to the TMEM19 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: H2B1K_BOVIN
Sequence: MPEPAKSAPAPKKGSKKAVTKAQKIDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B type 1-K.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TTC14_DROME
Sequence: MNFDYIGQALGYHGQPLQKIWDDERGVDDLRLMGLTQVNYGVYQERQKYFTFQERAKRLKMHQFLARKATDLYDRTLVANVMEDSLLAQGNTYMTQMAPFEFFLNVKDKRKGWAHRLSALKQGDIIYTQVTRLASGNRLIVKPLCTAEPKHAYLADIPIKAVILQDFWGPLPLDKQGNPRSFVQNDILRCEINNISADTERLSLNMIGMFNKVPDLKFGLCDFKELPKYYSKIHNLDHPSASHYEDELNKALEFENPNYDLLFQMNGLQPNENLSLMSYLRAGFPEEENAAELRQKQASQWAFRSVADGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLVALGRSYEEENRIAEAVKAYSDCLNLLPLHEEARQSLDALHRSGDGKRRISTEPSNMTGGQSSDESSSSSASDSECEDSAGKPKSNISQPFYAQHKLKQSGDEKLAVIDAHKANEFRLDDDETVSSVRKLLREASKHKKAKKKGKKKKDKKERRRSRTKSETEDPIELLKKIDFQEALRQDNKLMNSTRSDEERKAKIKSYLKEGGKESPPPPPPMKKTAVSSRKSSFDNVGPSTSRHAASVVGFGGAQPPPAPKFLGQKKHPEPAPKLSFQIKKRPLQMDKLGMLRLAAPAEPLKGGRSSSSRSRSRSRSRSRSRSRNRRLGRSTRSSLRSRRSGSRSRSISRSRSRRRRTYSRSRSPSPRSYGNRFVIGRYRNRRTRRSRSFHRRRSPSPILKRRSPSPFVPRRTPSPASRYRRSRSRSRSRSRSRSPRRFQSRYMPRDRGSVNRSRYSWHNPHKRSVSRTVEPNGKDERAATPPKKGVADDRSGREERA
What are the official names of this protein?
Tetratricopeptide repeat protein 14 homolog, TPR repeat protein 14 homolog.
What is the protein family that this protein belongs to?
Belongs to the TTC14 family.
Protein: Y182_METJA
Sequence: MSKLDKNEFICLKFDAWLYEKDDNLPYSLLEFIWDELEAKLNKDETITKEIKDKIKKLGKKSVNLWKNMVLGAINATNIKAGTSPITELSGIKINASFDGSKFVGYVVNASKEDENEEESYHKKVKELQNCFKELSKTLADNGKKLIIFIDELDRCEAENILNLLASIKLFFSLGGEDEDENKNDDEIKILFIL
What are the official names of this protein?
Uncharacterized protein MJ0182.
Protein: TATB_STUS1
Sequence: MFDIGFTELLLVGLVALMVLGPERLPGAVRTTGLWVGRLKRSFSNIKAEVEREIGADEIRRQLHNERILDLEREMKQSIMPPPASNPAATPPSPPSEGAGQPANAASSSPGDTVTPAANPPAPSTETAQPLRSDRPSEP
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
Protein: NALP7_HUMAN
Sequence: MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTIDCNASGATAPPCCDFFC
What is the function of this protein?
Inhibits CASP1/caspase-1-dependent IL1B secretion.
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 7, Nucleotide-binding oligomerization domain protein 12, PYRIN-containing APAF1-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
Protein: HEM1_CYAP4
Sequence: MNIAVVGLSHKTAPVEVREKLSVPEDGLEGAIAQLCSYPHIEEVAILSTCNRLEIYIVTSETESGIREVTQFLSEWSHLPLRELRQHLFILLHQDAVMHLMRVAAGLDSLVIGEGQILSQVKNTHKLGQQYNGIGTILNRLFKQAITAGKRVRTETSIGTGAVSISSAAVELAQLKTPCLADCRVAVLGAGKMSRLVVQHLLAKGANQIAILNRSTERARELANQFSEASLQIHSLAELFNVITRYDLIFTGTSATEPLLDRSKLEPVLEVNQSLMIIDIAVPRNVHANVNELEQVQVFNVDDLKAVVAQNQESRRAMAMEAEALLEEELTAFDVWWRSLETVPTISSLRDKIETIREQELEKALSRLGSEFAEKHQEVIEALTRGIVNKILHDPMVQLRAQQDRETRRRAMQSLQMLFNLPVNDSVVNVNS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: FLOA_STAHJ
Sequence: MFGLGIIVIAVIIVIALLVLFSFVPVGLWISAIAAGVKVGIGTLVGMRLRRVSPRKVIGPLIKAHKAGLNLTTNQLESHYLAGGNVDRVVDANIAAQRADINLPFERGAAIDLAGRDVLEAVQMSVNPKVIETPFITGVAMNGIEVKAKARITVRANISRLVGGSGEETIIARVGEGIVSTIGSSEHHTQVLENPDNISKTVLSKGLDSGTAFEILSIDIADVDIGKNIGADLQTEQALADKNIAQAKAEERRAMAVASEQEMKARVQEMRAKVVEAESEVPLAMAEALREGNLGVKDYYNLKNVEADTGMRNAINKRTEQNEDESPK
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: MTPS_PROST
Sequence: MTEAATQLPISLNILVDSIREAANSTLDETLRSKLGQFMSSSAVSELMANLFESYVGEHEILDAGAGVGSLTAAFVQNATLNGAKSISSTCYEISEVMVYNLIQVLDLCKIRAMEFEVNWQQKIIESDFIQASVEQLLIENYSPKYNKAILNPPYLKIAAKGRERALLQKVGIEASNLYSAFVALAIKQLKSGGELVAITPRSFCNGPYFNDFRKQMLDECSLNKIHVFNSRKSAFKADNVLQENIIYHLTKGETQRKVVTVYSSTCANDINPTIFEVPFDEIVKSNNPDLFIHIVTNEQERELANKAGGLPCSLSDLGIQVSTGKVVDFRTRENLSMEYISNSVPLIFPQHLQRCSIVWPITKAKKPNALIVNEATNNLMVPNGIYVLTRRLTAKEEKRRIVASIYYPDIANVDTVGFDNKINYFHANGKPLDISLAKGLWVFLNSTLIDKYFRQMNGHTQVNATDLRALRYPTREQLEDIANQVDFGEFEQTKIDEIINQSLQLM
What is the function of this protein?
A gamma subtype methylase that recognizes the double-stranded sequence 5'-CTGCAG-3', methylates A-5 on both strands, and protects the DNA from cleavage by the PstI endonuclease.
What are the official names of this protein?
Type II methyltransferase M.PstI, M.PstI, Adenine-specific methyltransferase PstI, Modification methylase PstI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: END4_LISIN
Sequence: MLRLGSHVSMSGKKMLLGASEEAASYGSNTFMIYTGAPQNTRRKPIEELNIEAGLEHMKAHDMADIVVHAPYIINIGNSVKPETFELGVNFLQSEIERTRALGAKQIVLHPGAHVGEGADKGIKQIIQGLNEALIHDQDVQIALETMAGKGSECGRTFEELAQIIDGVTHNELLSVTFDTCHTHDAGYDIVNDFDGVLNEFDKIIGIDRLKVLHINDSKNERGAHKDRHANIGFGHIGFDALHYIVHHPQLSNIPKILETPYVGEDKASKKAPYKWEIAMLRNGEFDPDLLNKIQNS
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: DEOC_SHEFN
Sequence: MTDLKKAAQRGIELMDLTTLNDDDTDQKVIDLCHKAKSPAGNTAAICIYPRFIPIARKTLNELDCEDIKIATVTNFPHGNDDIAIAVLETRAAVAYGADEVDVVFPYRALMDGNETVGFEMVKACKEECGDDAILKVIIESGVLKDPALIRKASELAIDAGADFIKTSTGKVPVNATLEAAEIMLTVISEKNRNVGFKPAGGVRDAAQTAEFLDLAARILGDDWVTPQTFRFGASSLLNSLLHTLELVDAPKPTSGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_BORBU
Sequence: MIKRYEACFLFKSEEIEYKGSLEEVKKSLEFFGATDVVSNFIGERALEYPIKKQARGRYEIIEFSMEGNNLKEFESRLKLIRNLLRYMILVKIVRKINTKKIKRRNFREFRDNIDKDSLKGASKVETPTGPESTDIQEK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: FTSH_PELPB
Sequence: MSENPVKRPGKDGSRNKFKPVQEEGGTPGWFRSKGESPQGKFPGFLLFLMAGLLMLFVFLRFFSGTDAPEITYNEYKSVLSRALVTEVTVKTYEDKSAILSGKLNAPAQLQLIDKTTLQTNRFAVRVPSFTLEQADMLTEKGVRLKVEKGSSDLNTFLALFAPWIIFAALYFFLFRRMSGQNGAQAKNIFSFGKSRAKMVSEFEVKTTFKDVAGVDEAIEELQETVEFLTNPEKFQKIGGKIPKGVLLLGPPGTGKTLLAKAIAGEAKVPFFSISGADFVEMFVGVGAARVRDLFEQAKKNAPCIIFIDEIDAVGRSRGAGLGGGHDEREQTLNQLLVEMDGFTTNENVILIAATNRPDVLDSALLRPGRFDRQITIDKPDIRGREAILKIHTRNTPLDGDVDITVLAKSSPGFSGADLANLVNEAALLAARHEQVLITAVNFEQARDKILMGPERRSMFISDEQKKLTAYHEAGHVLVSIHTKGSDPIHKVTIIPRGRSLGLTAYLPLEDRYTHNREYLLAMITYALGGRVAEELVFQECSTGAANDIEKATDIARRMVRQWGMSESLGPINYGDSHKEVFLGKDYSHIREYSEETALQIDVEVRNIIMGCMENAKTVLSEQLAVLHRLAGILIEKESLNAREIQEITGPGQGALPNPVTA
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.