PharMolix/UniProtQA huggingface dataset:
Protein: PLAK_MOUSE
Sequence: MEVMNLIEQPIKVTEWQQTYTYDSGIHSGVNTCVPSVSSKGIMDEDDACGRQYTLKKTTTYTQGVPQNQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQTTNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYADDMDATYRPMYSSDVPLDPLDMHMDLDGDYPMDTYSDGLRPPYPTADHMLA
What is the function of this protein?
Common junctional plaque protein.  The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue.  The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.  Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells.  Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
What are the official names of this protein?
Junction plakoglobin, Desmoplakin III, Desmoplakin-3.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form.
Protein: Y3975_ARATH
Sequence: MKALFEARINFIVTEKQIKRVRAPNEDWLQDDEVDVVLRFSNVVKLMNGIQNVQKLYLTADTIEVLSLCCESVPLFNNLKTLGITSEEGRGWQAMPVLGLLHYMTDKCGDACDCISREDKGRSLTSCPVKKLEIRGFRGTMKEMTMIKHFLVYFPCLKEMNIYVEEYDPTELRFPQVSKVIIQMMEEYNKLSSCNVQLLITDYLSEKWTAAGRIL
What are the official names of this protein?
FBD domain-containing protein At3g58975.
Protein: MTMR_DICDI
Sequence: MFSNKNTDNVENDNNNALGSVIARINSQNIITKNKAPVISEDFETQDFDYPSFDDETPNYDRPQPTMVENFTLLPGEFVLMITKNVVNLSLTTTTHRIGTLYQTNYQMFFIDDSTRQLVSTIANGQLLQIKKLKGHVTVKYHDNTTPNNNNNNNNNNNNNNNNTNNNNNNNINKSNNSSTDQLNSFSLEKQPSQNENLNNNNNNNNNNNNGNNNINNNNLMNSLTQPSTSSRSRLLKSNSTPINLNESSTSTNSPTLSSTTTTTTTTSSTNGNCSTNTWYSNGVSEKALILEIRCKDFMITRYCLPFNEKGNEAFELMNKLICNNYQDSNQLFSMSYSPFKGVISPIDGWLFYDPIEEYTRQGLIGNSNGSDEWRLTKMNSKYELCSTYPQHFIIPFSISDYLLNKSSSHRNKNRFPVVTWRHKQTHATLSRSSQQTGKSRCEEDELLIQAIRKSKTILPNNNNQQQQPQQQQQTLYIIDIKSTSSSPTSSSSSHCEDISHYSQCQIESECLSNIHELRESQLKLFKVIRNWNEKKGWSEIQSTGWLDQLSKLLMVTKKILTHLHLEGFSCLIHCIDGWDRTCQLSSLVQLCADPYYRTIKGFIVLISKEWLSFGHKFMTRNGQSISSTSTTTTNSSSNGQLTSSSSNTSISSNATTTTTTTTSSKQTSPVFLQFIDVVWQLTKQFPTSFEFSDSFLSVILHHLNSNLFGTFLYDSEKERQQNNLPTETQSLWTLLLSAQKNSSLLNPLFNQQLSNETSSTTNLTATTSIPLTNSTTLDQQLQFKNNNDDGVLFPNPKGVQLWSDYFLKWRNPPKASRKSNTLIAHSLGVSYVNGDLIAFQKKKRSRRSKDGASGSSSGSSGSSSKHHHHHHHHHHHHHHRKSTDEKDSKEKSSKSSRSRTSSSSKRKSLSTSSNSITQPDIKINETITTTTTTPTNTTTLTNTSTTPRNTTTLTNASTTPTTTTTTTTTTTPTKDETINESVQVNNDKLKSPSGDDIKQEQDEMNQFTSQHPNNQMESSSEINQQNEQSQLEQQQEQQQQQEQQLQHEQQQIEQQQLQKQQQQQEQQEQQELEQQEQPNETITYSMESDSQSSISQNQNQLQQQQQQQTLLDPIDESSLLATTTTTTSSTAITSASKLEKELRKQEKEKRKLEKEKKQKERAERKLEKEKKRDQKEREQKEKELLEQQKPKADITVVLQSPSKKKAMSLTMPVRGTKSRISIFSSPLVPTLHPNLSDQNSQTNSSGDNSGNVNNSPNLTSTPISNLSNNNNNNNNSNENSNNNNNNNNNNNDNTSFSKRIFKTLRGTKTFNREPTPTVGTALN
What is the function of this protein?
Phosphatase that acts on lipids with a phosphoinositol headgroup.
What are the official names of this protein?
Myotubularin-related protein DDB_G0290005.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHJ_NOSP7
Sequence: MAEEESKPVPAEKEESLVQAGKVSQWLTENGFDHEFLAPDKNGVEIIKVSADFLLPTATALYAYGFNYLQCQGGIDLGPGQELVSMYHLIKVGDNSDRPEEVRVKVFLPRENPVVPSVYWIWKTADWQERESYDMFGIIYEGHPNLKRLLMPEDWVGWPLRKDYISPDFYELQDAY
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J, NDH-1 subunit J, NDH-J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NODB_BRASP
Sequence: MTEFIPLFAVRRNYGDVSGTRSVYLTFDDGPNPFCTPDVLDVLTQHRVPATFFVIGTYVANQPELIRRMVAEGHEVANHTMTHPDLSRCEPAEVHDEVLTASRAIRSACPQALPRHMRAPYGIWTQDVLATSAKAGLAAVHWSVDPRDWARPGVDRIVSSVLAAIRPGAIVLLHDGYPPGEERSCTDATSRDQTVRALSYLIPALQRRGFEIHPLPQLH
What is the function of this protein?
Is involved in generating a small heat-stable compound (Nod), an acylated oligomer of N-acetylglucosamine, that stimulates mitosis in various plant protoplasts.
What are the official names of this protein?
Chitooligosaccharide deacetylase, Nodulation protein B.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSSR_STAAW
Sequence: MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDGFQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYNINSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWGYDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
What is the function of this protein?
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence.  Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
What are the official names of this protein?
Heme response regulator HssR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_NEOSM
Sequence: MIGKLTGTVTDLCQESLILDVGGVGYNVFTTRRLIDSLRTGQNLSLYIEHYFLENINKLYGFECRKSQEVARMLSKVKGINYKIALSLLNHLELGELILAIQNKDESRLKIKGIGEKLVKRIITETYEDFLKLDSHLSGIASSTNVHIASEAVSALVKLGFQHKPSHKVVMEIMTKRPAIEIAELITLALKML
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: LOVA_ASPTE
Sequence: MTVDALTQPHHLLSLAWNDTQQHGSWFAPLVTTSAGLLCLLLYLCSSGRRSDLPVFNPKTWWELTTMRAKRDFDANAPSWIESWFSQNDKPIRFIVDSGYCTILPSSMADEFRKMKELCMYKFLGTDFHSHLPGFDGFKEVTRDAHLITKVVMNQFQTQAPKYVKPLANEASGIITDIFGDSNEWHTVPVYNQCLDLVTRTVTFIMVGSKLAHNEEWLDIAKHHAVTMAIQARQLRLWPVILRPLVHWLEPQGAKLRAQVRRARQLLDPIIQERRAERDACRAKGIEPPRYVDSIQWFEDTAKGKWYDAAGAQLAMDFAGIYGTSDLLIGGLVDIVRHPHLLEPLRDEIRTVIGQGGWTPASLYKLKLLDSCLKESQRVKPVECATMRSYALQDVTFSNGTFIPKGELVAVAADRMSNPEVWPEPAKYDPYRYMRLREDPAKAFSAQLENTNGDHIGFGWHPRACPGRFFASKEIKMMLAYLLIRYDWKVVPDEPLQYYRHSFSVRIHPTTKLMMRRRDEDIRLPGSL
What is the function of this protein?
Dihydromonacolin L monooxygenase; part of the gene cluster that mediates the biosynthesis of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR) (PubMed:10334994, PubMed:12929390, PubMed:21495633).  The first step in the biosynthesis of lovastatin is the production of dihydromonacolin L acid by the lovastatin nonaketide synthase lovB and the trans-acting enoyl reductase lovC via condensation of one acetyl-CoA unit and 8 malonyl-CoA units (PubMed:10334994, PubMed:10381407, PubMed:19900898, PubMed:22733743).  Dihydromonacolin L acid is released from lovB by the thioesterase lovG (PubMed:23653178).  Next, dihydromonacolin L acid is oxidized by the dihydromonacolin L monooxygenase lovA twice to form monacolin J acid (PubMed:12929390, PubMed:21495633).  The 2-methylbutyrate moiety of lovastatin is synthesized by the lovastatin diketide synthase lovF via condensation of one acetyl-CoA unit and one malonyl-CoA unit (PubMed:19530726, PubMed:21069965).  Finally, the covalent attachment of this moiety to monacolin J acid is catalyzed by the transesterase lovD to yield lovastatin (PubMed:10334994, PubMed:17113998, PubMed:18988191, PubMed:19875080, PubMed:24727900).  LovD has broad substrate specificity and can also convert monacolin J to simvastatin using alpha-dimethylbutanoyl-S-methyl-3-mercaptopropionate (DMB-S-MMP) as the thioester acyl donor, and can also catalyze the reverse reaction and function as hydrolase in vitro (PubMed:19875080).  LovD has much higher activity with LovF-bound 2-methylbutanoate than with free diketide substrates (PubMed:21069965).
What are the official names of this protein?
Dihydromonacolin L monooxygenase LovA, Dihydromonacolin L hydroxylase, Lovastatin biosynthesis cluster protein A, Monacolin L hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: PLSX_PSEPK
Sequence: MSAQVIAIDAMGGDFGPRSIVQASIACLSATPSLHLTLVGQPSLLEDLISGLPAADRARLQVVAASEVVGMDERPSQALRGKPDSSMRIALELVRDGKAQACVSAGNTGALMALSRFVLKTLPGIDRPAMVAAIPTQTGYCQLLDLGANVDCSAENLYQFAVMGSVAAQALGVHRPRVALLNIGTEDIKGNQQVKLAATLLQSARGLNYVGFVEGDGLYRGEADVVVCDGFVGNILLKSSEGLATMIGARIEKLFKGGAFARVAGAVAMPLLKRLQADLAPARHNGASFLGLQGIVIKSHGSAGVQGFQSAIQRALIEIQENLPQRLHGRLEDLLP
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RS10_SYNY3
Sequence: MATLQQQKIRIRLKAFDRRLLDTSCDKIVDTANRTNAAAVGPIPLPTKRKIYCVLRSPHVDKDSREHFETRTHRRIIDIYQPSSKTIDALMKLDLPAGVDIEVKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: DARCH_STRCO
Sequence: MPEETAHTPVTAFMLVKTTPEWLALTVEERVHAFTTEVVPVVRARTAGVRSRFYDTEFYSARVTDVWVWEADDHHAYQLLVDALRETPFWDRYFEVVDLLVGTENGYARTYGVDAVTTLST
What are the official names of this protein?
Darcynin homolog.
What is the protein family that this protein belongs to?
Belongs to the darcynin family.
Protein: H2A1_TETTS
Sequence: MSTTGKGGKAKGKTASSKQVSRSARAGLQFPVGRISRFLKNGRYSERIGTGAPVYLAAVLEYLAAEVLELAGNAAKDNKKTRIVPRHILLAIRNDEELNKLMANTTIADGGVLPNINPMLLPSKTKKSTEPEH
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.1, Histone H2A.2, H2A2.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to both the large, transcriptionally active, somatic macronucleus (MAC) and the small, transcriptionally inert, germ line micronucleus (MIC).
Protein: ALR_RICBR
Sequence: MSLCTLEINLSAIKANYRLLKNICENSVDFLHNVANKEEFAGNTSPRTAAYTLVREDASLGSTPKLPLGASYAKNLLVGAAVKANSYGLGAIEISKTLLEENCRYFFVASSNEGISLRKAIGDEVNILILNGVFEHDALELIEYNLIPVLNNLNQIKIWQKFSNLKNQLLPCYLHFNTGINRLGLNHNEIEQLINNRDLLKGLNVEYIISHLSASEDSDNPYNLEQLNKFKAYLEYFPNAKASLANSGGIFLGKDYHFNLVRPGAALYGLNPLGSNKPNPMQNPVTLKAPIIHLQNLTYGSRIGYNMTFTTKRDSLIATLPFGYADGFSRNFSNQGTVFINSRNVPIIGRISMDLVNIDVTDLPPSDIFLGQEVEIIGNNCTPDKIADIIGTIGYEILTSLGNRYKRIYT
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: EFEU_ECOUT
Sequence: MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKEQELFEGIVAVIAVVILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNHHGWALVMMVFFAVAREGLESVFFLLAAFQQDVGIWPPLGAMLGLATAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFGYQEAPSVSEVAVWFIYLIPALVAFVLPPRAGATASRSV
What is the function of this protein?
Uptake of Fe(2+) ions across the membrane.
What are the official names of this protein?
Ferrous iron permease EfeU, Fe(2+) ion permease EfeU, Ferrous iron uptake protein.
What is the protein family that this protein belongs to?
Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TIM13_CANAL
Sequence: MAFWNSSSSSSSSGQTDSSSTSSPASLRSQQIKQDLQNQISQELAAANATELVRTITENCFDKCILIPKDTLSPTELQCISQCREKYMRSWNVISKAYIGRIQQEQHH
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.  The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM13.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: RS17_CLOBL
Sequence: MERSNRKTRIGRVVSNKMDKTIVVAVETKVRHPLYGKIMNRTTKFKAHDENNAANINDKVLIMETRPLSKQKRWRLVEVVEKAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: UP01_TOBAC
Sequence: LLSTLTDTSIKEAVATDKAP
What are the official names of this protein?
Unknown protein from 2D-PAGE.
Protein: ACMAT_VITLA
Sequence: MASPSSPLVFSVNRCVPQIVRPANPTPREVKQLSDIDDQEGRRFQIPVIMFYRNNPLMEGKDPVKVIREALGKALVYYYPFAGRLIEGDNRKLMVDCTGEGVLFIEADADTTLENLGDAIQPMCPCFEELLYDVPGSTTILGSPLILIQVTRLRCGGFIFALRLNHTMSDAAGLIQFLDTIGEMAQGLSVPSLLPIWQRELLNARNPPRITRIHHEYEKVTNTKGTLMAMDENSLVHRSFFFGREEIRALRNRLPASLGACSTFEVLMACVWRCRTIAFAVDPDEVVRISCIINMRGKHGFELPPGYYGNAFVTPASITKAGMLCKNPLEFAIRLVKKAKAEMSQEYIKSVADLMVIKGRPLFTQPGNFTVSDVTRAGLGEVDFGWGKPVYGGVARACPIISFRMLFRNSKGEEGSVIPIWLPPPVMERFEQELKRMTKKAELLITSML
What is the function of this protein?
Acyltransferase that catalyzes the formation of methyl anthranilate, a compound implicated in the 'foxy' odor character of Concord grapes.  Can use a variety of alcohol substrates when assayed with both benzoyl-CoA and anthraniloyl-CoA.
What are the official names of this protein?
Methanol O-anthraniloyltransferase, Anthraniloyl-CoA:methanol acyltransferase, Benzyl alcohol O-benzoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: ATD3A_DROME
Sequence: MSWLLGRNRQQPQPDQTAGFSEGGGAADPEGRTAGEKSGDSQLSRAERKAMEAYRFDSSALERAADAAKTLERSKHAREALELSKMQEATRQTEYNTKVKEYEAHIEQAKVEQKRIDHEERRKTLIEETKQQQQRAQYQDQLSRKRYEDQLLQQQRVQEENLRKQEESVQRQEAMRRQTIEHEIEMKEKNRLKLLEHELRAKARVDRENRDINLEKIRLKAQEHRTTVLEGIKTAGTVIGAGAEAMLTDWDKVLTAAGGLSLLALGVYTAKGATGVVSRYVEARIGKPTLVGETSRFAFLDALKNPLHYLKRLRAKPTDALQGVVLNPKLEERLRDIAIATKNTRINKGMYRNVLMHGPPGTGKTMFAKKLAEHSGMDFAIMTGGDVAPMGKEGVTAIHKVFDWSHTSRRGLLLFVDEADAFLRKRSSEKISEDLRAALNAFLYRTSEQNPKFMLVLASNTPEQFDYAINDRLDEMVEFTLPGLEERERLLRLYFDKYVLQPAAAGAKRFKLDTFDYGKTCSKMAALCEGMSGREISKLGVSWQAAVYASEDGLLTEKMVLDRCYSAAQQHKQKMAWLSDQERADHKSITGTAAPPLTLTAKKL
What is the function of this protein?
Required to maintain the proper number of mitochondria in neurons and muscles.
What are the official names of this protein?
ATPase family AAA domain-containing protein 3A homolog, Belphegor protein.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Mitochondrion matrix, mitochondrion nucleoid.
Protein: YJIK_SHIBS
Sequence: MTKSISLSKRISVIVILFAIVAVCTFFVQSCARKSNHAASFQNYHATIDGKEIAGITNNISSLTWSAQSNTLFSTINKPAAIVEMTTNGDFIRTIPLDFVKDLETIEYIGDNQFVISDERDYAIYVISLTPNSEVKILKKIKIPLQDSPTNCGFEGLAYSRQDHTFWFFKEKNPIEVYKVNGLLSSNELHISKDEALQRQFTLDDVSGAEFNQQKNTLLVLSHESRALQEVTLVGEVIGEISLTKGSRGLSHNIKQAEGIAMDASGNIYIVSEPNRFYRFTPKSSH
What are the official names of this protein?
Uncharacterized protein YjiK.
What is the protein family that this protein belongs to?
Belongs to the YjiK family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: FPG_ENT38
Sequence: MPELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSNEIHTLSDKPVLSVQRRAKYLLLELPDGWIIIHLGMSGSLRILSEELPAEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTKELEGHNVLAHLGPEPLSEAFNAEYLKARCAKKKTPIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSEQECEILVKVIKAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVASKHAQRATFYCRQCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: DDC_MANSE
Sequence: MNPGDFKDFAKAMTDYITEYLENIRDRQVVPSVKPGYLRPLVPEQAPQQAEPWTAVMADIERVVMSGVTHWQSPRFHAYFPTANSYPSIVADMLSGAIACIGFTWIASPACTELEVVMLDWLGQMLGLPDQFLARSGGEGGGVIQGTASEATFVALLGAKSRMMHRVKEQHPEWTETDILGKLVGYCNQQAHSSVERAGLLGGVKLRSLKPDSKRRLRGDTLREAIDEDIRNGLIPFYVVATLGTTSSCAFDALDEIGDVCNASDIWLHVDAAYAGSAFICPEYRHFMKGVEKADSFNFNPHKWMLVNFDCSAMWLKQPRWIVDAFNVDPLYLKHEQQGSAPDYRHWQIPLGRRFRSLKLWFVLRLYGVENLQKYIRKQIGFAHLFERLLTSDERFELFEEVTMGLVCFRLKGSNEINEELLRRINGRGKIHLVPSKVDDVYFLRLAICSRFTEESDMHVSWEEIKDRLMMFLKSKGAVLIKIICSTTRRTKNILTYIKQNIFRDVGL
What is the function of this protein?
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
What are the official names of this protein?
Aromatic-L-amino-acid decarboxylase, AADC, DOPA decarboxylase, DDC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: SYY_AQUAE
Sequence: MTPEEQLRIIKEGTVEIIEEEELLKKLKEGRPLRVKAGFDPTAPDLHLGHVVLLQKLRQFQQLGHEVFFIIGDFTAMIGDPTGRSQTRPPLSREQVLENAKTYEHQVFKVLIPEKTTVVFNSTWLEELGTKGLIELCAKYTVARMLEREDFSKRFKEGIPIYIHEFIYPLLQAYDSVAIKADVEIGGTDQKFNLLIGRDIQREYGQEPQVCITLPLLVGTDGVRKMSKSYGNYVGITEDPKTMFAKIMSIPDEIMWDWFLLLTDYNKEEIEKMRREMHPMEAKKLLAFTIVKRFHSEEEARKAKEWWEKTFSQREFPEDAPLVKLNEKKLRAVDFLVKIGAVKSKNEARRVIQGGGLKINGEKVTDPNTEIEINGELKVKVGKKKFYRVVSG
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CZF1_CANAW
Sequence: MSSIPNINWNDPNNGKSNTSRQSQPQPQLPSNVSPPNSRAVPTSGSIGGPQYGSSQFSNEYSRNPNTIGGPPFPLQSNQRGYMPNTGYPVQQTAQQRSGDKLQQVHSQQQQQQQQQQQPLYQQYPPQSVGYLAGDVYNPQHQEYVQMNQLPNQHYNLQQRQQAQGQQLKSQLNEQNAMMSASTQQYPVQDFTNPYPNAQNPAEQQQQQQPLRTQSQQWDGYQSQPLYSAAGNTIPSSIQQQIPPQNLSPSEQQQVKQQQPSPPEQGTKKKPGRKPKLRKLSESSSETPQVPKTASSSSSSPTAVNSGKPITKRSRMGCLTCRQRKKRCCETRPRCTECTRLRLNCTWPKPGTEHKNKPKDQKDDENTIEHAEFGRIKVLRGIVEYRSK
What is the function of this protein?
Perhaps a regulatory role.  May be involved in transcriptional activation.
What are the official names of this protein?
Zinc finger protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: IL2_PAPAN
Sequence: MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELRPLEEVLNLAQSKNFHLRDTKDLISNINVIVLELKGSETTLMCEYADETATIVEFLNRWITFCQSIISTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.