PharMolix/UniProtQA huggingface dataset:
Protein: COBS_BRUA1
Sequence: MQRNGLIGDTIRSLGFLSRLPLPQGWFDNTDDSLPRNARAFPLAGGILGLLAGVALLIANAISLPPLAAALIAIGALAAMTGALHEDGLGDTADGFFGASTPDRRLDIMKDSRIGTFAALTLVIWTGVKASLLMAIIARAGAGYALLALIGTEAASRAGMLAFWHALPSARPGGLADSMGQPQWETVVCGCGLGLALLAIGFLPSGGMVALINALVLMTVVLFGFARLCMAKIGGQTGDTLGAAQQIGSLAALIGLVMAL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLPE_PSESM
Sequence: MTEFKRIPPEQAQALRAQGAVLVDVRDAQAFQSNHIPDSQHLDNHSIADFIANADLDKPLVVVCYHGNSSQSAAAYLVGQGFSDVYSVDGGFERWRSTFPEETAQG
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1503_XANP2
Sequence: MASTASLRVAPQADTYAAYQTPLAVRQACRSGALTGPTAGMAPGYVQGNLAVLPKELAEEFLRFCHFNPRPCPVIGMSEPGSFKVPVLGEDLDIRTDFPGYRVWQDGEVIADTADVTDYWRDDLVAFVIGCSLSFEEALMAEGLPLRHVDRNVRVPMFRTTVQCVPAGRFSGRMVMSMRPLVPAHAIRAIQITTRFPQVHGAPLHVGLPELIGVKDLMKPDYGDAVEVLDNELPVFWACGVTPQSVIAEAKPSFAITHAPGCMLVTDRRNTEFAIL
What are the official names of this protein?
Putative hydro-lyase Xaut_1503.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: GLMM_FRATH
Sequence: MAKYFGTDGIRGEVANSTITVEFTQKLGNAVGSLINQKNYPKFVIVGQDTRSSGGFLKFALVSGLNAAGIDVLDLGVVPTPVVAFMTVKHRAAAGFVITASHNKFTDNGIKLFSSNGFKLDDALEEEVEDMIDGDFIYQPQFKFGSYKILANAIDEYIESIHSRFAKFVNYKGKVVVDCAHGAASHNFEALLDKFGINYVSIASNPDGLNINVGCGATCVSNIKKAVKEQKADLGISLDGDADRIIIVDENGQEIDGDGILNILAQYSDICGGTNGIVGTQMTNMSYENHYRANKIPFIRSKVGDRYVLEDLVKYGYKIGGESSGHVINLNFGTTGDGLFTAIQLLAIFSQAYKPVSEFKLQGELMQQTLINVPLTKKVAREDLQKVASDVNDVEKRLGNRGRVLLRPSGTEPVLRVMVEADDKSLATNEAEYLVEKVKQKLV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: PKHA5_HUMAN
Sequence: MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV
What are the official names of this protein?
Pleckstrin homology domain-containing family A member 5, PH domain-containing family A member 5, Phosphoinositol 3-phosphate-binding protein 2, PEPP-2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE2_PSEPW
Sequence: MIPGEIQVAAGDIELNVGRETVSVNVANHGDRPVQVGSHYHFYEVNDALVFDREPSRGFRLDIPAGTAVRFEPGQARTVQLVAYAGKREVYGFQGKVMGALEGKA
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HNF1B_PONAB
Sequence: MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSQGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEVTSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSISTLTNMSSSKQCPLQAW
What is the function of this protein?
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity).  Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity).  Transcriptional activity is increased by coactivator PCBD1 (By similarity).
What are the official names of this protein?
Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, Transcription factor 2, TCF-2.
What is the protein family that this protein belongs to?
Belongs to the HNF1 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RAB42_HUMAN
Sequence: MEAEGCRYQFRVALLGDAAVGKTSLLRSYVAGAPGAPEPEPEPEPTVGAECYRRALQLRAGPRVKLQLWDTAGHERFRCITRSFYRNVVGVLLVFDVTNRKSFEHIQDWHQEVMATQGPDKVIFLLVGHKSDLQSTRCVSAQEAEELAASLGMAFVETSVKNNCNVDLAFDTLADAIQQALQQGDIKLEEGWGGVRLIHKTQIPRSPSRKQHSGPCQC
What are the official names of this protein?
Ras-related protein Rab-42.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor.
Protein: UXAC_CROS8
Sequence: MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAENYRFKNLYDIWLKGDHYKWRAMRTNGVPERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPKTADEIWNQCNDLLAQDAFSARGIMQQMNVKMVGTTDDPIDSLEHHATIAKDSAFTVKVLPSWRPDKAFNIEQATFADYMAKLAEVSDTDIRRFSDLQTALTKRLDHFAAHGCKVSDHALDVVLFAEASESELNAILSRRLAGETLSGHEIAQFKTAVLVWLGAEYARRGWVQQYHIGALRNNNQRQFRLLGPDVGFDSINDRPLAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADIDLLGEMVKNICFNNARDYFAIELH
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: ISPH_AGRRK
Sequence: MNIAVSKPDLTIRLCGPRGFCAGVDRAIQIVVLALKSYGAPVYVRHEIVHNRYVVEGLEAKGAIFVEELDEIPAEHRAQPVVFSAHGVPKAVPEDADARNLFYLDATCPLVSKVHKQAMRHNRLGRHVVLIGHAGHPEVIGTMGQLPEGTVSLIETVEDVDVYEPADPDNLGYVTQTTLSVDDTAGVIARLQERFPNLTAPSADSICYATTNRQEVVKQAAPGCDLFIVVGAPNSSNSKRLVEVALRAGATKSVLVQRAAEIDWDDIGDIKTVGLSAGASAPEVIVNEIIEAFRDRYSAVVELAETVKETENFLVNRELRNIELTTADMAFVNGE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: TSAD_STRT2
Sequence: MADRYILAVESSCDETSVAVLKNEKELLSNIIASQVESHKRFGGVVPEVASRHHVEVVTLCIKDALSEAGIVAEQLDAVAVTYGPGLVGALLVGMAAAKAFAWAHGLPLIPVNHMAGHLMAAREVQELEYPLLALLVSGGHTELVYVSEPGNYKIVGETRDDAVGEAYDKVGRVMGLTYPAGREIDELAHKGKDVYDFPRAMIKEDHLEFSFSGLKSAFINLHHNAEQKGEVLVTEDLCASFQAAVLDILLAKTKKALERYPVKTLVVAGGVAANQGLRERLAEEITDVDVVIPPLRLCGDNAGMIALAAAIECDKKHFADLDLNAKPSLAFAGFEE
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_BURMA
Sequence: MRHRHGLRKLNRTSSHRLAMLRNMSNSLIEHEVIKTTLPKAKELRKVVEPLITLGKKPSLANRRLAFNRLRDRDSVAKLFDVLGPRFANRPGGYLRILKFGFRVGDNAPMALVELLDRPEVEETENVQEAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: H3_ASPNC
Sequence: MARTKQTARKSTGGKAPRKQLASKAARKAAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVEAYLVSLFEDTNLCAIHAKRVTIQSKDIQLARRLRGERS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ATQA_ASPTN
Sequence: MTRTEILSNGHAEPASNGMVQYPFDNVVDALRAAANTTEGIIAYQTNNSGSETTPAQHISYKELLRTAEANAALLQSKHLTTPKQPVVVHSDNAVDSMIWYWSVLLTGAIPTMTGPGMFSQDAVERKKHLLHLHRTLDAPLCLTRRALMGPFNENAGLLQCLAFEDLSPSPDGSNASLPPSINPSPMDVAALMLTSGSSGTAKAVPITHQQVLAALRGKTAVAQLSHPTSPFLSWVHMDHVANLVHCHLFAIVAGVSQVQVPAANVLVDPMQLLNLLSRHRVSRTFAPNFLFAKLRRQFDAGRTDSLDADLNLAALYLDTGGEANVIDVCAGLQPILARYGAPADVFKPSFGMTETCAGCIFNSHCPSYDQARLHEFASLGTPMPGVRMRISRLDGSGEAAPGERGHLEITGEAIFHGYYNNPTATADAFTADGWFRTGDLAYIDAGGHLHLDGRTKEMVNINGVKYLPHELDAALEQAEIPGATPTYFCCFGTRTAAMDTEVVAVLYLPAYDEADDAARFDAQSSIIRLISMYTHSRPRVVPLRREDMPKTTLGKLSRAKLQAALEAGQFAAYEAANEAAIRRHRDTMRGEPASAEEATILSIIREQLEIPEADDFGVTDSILSMGATSMDLVAIMQRVNRQLQLRKTLALTDMLNYATARGLCQRIAATSGTGRKHVYDPVVVLQPHGRKTPLWLVHPGVGEVLVFVNLAHHITDRPVYAFRAKGFNAAEGETPFTSLEEVFETYKAAMKARQPQGPYAIAGYSFGGMVAFEIAKRLEAEGDEVRYCGSWNLPPHIKWRMKQLLWDECIIHLFYFVDLMDEETAYTHKPKLCELERQGRRLEAVRYLRQHSNPARWDELGLSEEYYLLWVNLASNMQGMATEYEPSGNVKHLDVFVADPLTHVARTREEWVNGLLAAWKDFVREGVRYHHVEGAHYTMLKPEYVANFAKTLRTVLRERGV
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of asterriquinone CT5, a natural product that displays potential biological activities including antitumor and insulin mimic activities (PubMed:23841722).  The nonribosomal peptide synthetase atqA is responsible for the production of the benzoquinone derivative didemethylasterriquinone D (DDAQ D), via condensation of 2 indole pyruvic acid (IPA) molecules (PubMed:23841722).  The symmetric connectivity of the 2 IPA molecules is thought to arise by head-to-tail dual Claisen condensations catalyzed by the TE domain of atqA (By similarity).  DDAQ D represents the core structure of asterriquinones and is further modified by yet unidentified tailoring enzymes to lead to the production of asterriquinone CT5 (PubMed:23841722).
What are the official names of this protein?
Nonribosomal peptide synthetase atqA, Didemethylasterriquinone synthetase.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
Protein: SLN14_RABIT
Sequence: MEIPKTGVETLYPEFVVEVGRVTFGEENRKKMTNSCLKRTENLNIIKATCALLNSGGGVIKAEIHDKNYNYQCHGLGHDLETSFQKLLPFGSQKYLDYMQQGHELLIFVKSWNPDVSSLLPLRICSLRSNLYQRDVTSAINLSASSALELLREKQHAAQRGRRRLHPPRASNSNLQEEEDMKMLASEVFKKDRLMYKEKLNFTESTHVEFKRFTTKKVVPRIKEMLPHYVSAFANTQGGYLIIGVDDKSKEVFGCKKEKVNPDLLKKEIENCIEKLPTFHFCHEKPKINFITKILNVYQKDVLYGYVCVVQVEPFCCAVFAEAPDSWVMRDNAATRLTAEDWVLMMLDIPSAPCNLVTDSNAHLKSPASSAFRSPVCPTKVLEFKGALQRHLFPVTQKTIQFKPESFCKKLFSDHKGLEDLMKTQTYPYSQGIVVFSRSWAGDVGLRKEDRVLCDALLIALHSPLVLYTVLIDPSWAGGREYAWNVALHLKRKLQSVGGYPGKVGIIPRLIQLAGTWCGPGDGSVHYPQSYQLATEDDMEDLLQALVVVSLCSRSLLSDQLGCEFFNLLIAEQCEVLSQSLQETRELFIHCFPGTRKTALAIKTLEKIRDLFRCRPKEILYVCESDFLRDFVIHQTACLAVTRKTFMQGEFPKIKHIVMDETENFCSKYGDWYSKARSITHPRVRGAGNEDLHHGILWIFLDPFQVRHSDVNGLPPPPAQFPRKTITNGIHCAQEIAKVMKGAMKRITENPPSNMSPHTLALFREAACGEALGAHALPGVCETKADLTVEQIANYVAERCHGLFQCGYLPKDVAILCRREEDRARYKLALLRAMELTETHSATEVVFSQAAGVQGEHIILDSVHQFSGLHRNIVFGLSPEQRLSEEFHQLCFASKAIKHLYLLYERGQVSENYYK
What is the function of this protein?
Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083).  May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable).  Cleaves RNAs in a magnesium-, manganese-dependent and ATP-independent manner (PubMed:25996083).  Involved in correct maturation of megakaryocytes and especially important for proplatelet extension (By similarity).
What are the official names of this protein?
Protein SLFN14.
What are the subcellular locations of this protein?
[Protein SLFN14]: Nucleus.
Protein: ISF_METTE
Sequence: MKITGISGSPRKGQNCEKIIGAALEVAKERGFETDTVFISNEEVAPCKACGACRDQDFCVIDDDMDEIYEKMRAADGIIVAAPVYMGNYPAQLKALFDRSVLLRRKNFALKNKVGAALSVGGSRNGGQEKTIQSIHDWMHIHGMIVVGDNSHFGGITWNPAEEDTVGMQTVSETAKKLCDVLELIQKNRDK
What is the function of this protein?
Redox-active protein probably involved in electron transport during fermentation of acetate to methane.
What are the official names of this protein?
Iron-sulfur flavoprotein, Isf.
What is the protein family that this protein belongs to?
Belongs to the SsuE family. Isf subfamily.
Protein: ILVC_ALKMQ
Sequence: MAKLYYEKDCNLEVLKGKKVAIIGYGSQGHAHALNLKNSGVDVVVGLYEGSKSWERAEAEGLKVAVASDAAAEADVVVILVNDEKQVQVYEESIKPNLTAGKYLMFAHGFNIHYGQIVPSEDVNVFMVAPKGPGHTVRSQYQEGKGVPCLVSVYQDATGNTMDVALAYAAGIGGARAGVLKTTFKEETETDLFGEQAVLCGGVTELMKVGFEVLVEAGYEPESAYFECVHEMKLIIDMVVEGGLGNMRQSISDTAEYGDYSVGKRIITDETKKEMKKVLHEVQDGTFARNWILENKANRPAFTARRRMEQSHQVEVVGKELRDMMSWSKQSKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: HEMA_INCNA
Sequence: EKIKICLQKQVNSSFSLHNGFGGNLYATEEKRMFELVKPKAGASVLNQSTWIGFGDSRTDKSNPNFPRSADVSVKTANKFRSLTGGSLMLSMFGPPGKVDYLYQGCGKHKVFYEGVNWSPHAAIDCYRKNWTDIKLNFQKNIYELASQSHCMSLVNALDKTIPLQATAGVAGNCNNSFLKNPALYTQEVTPPXXKCGKENLAFFTLPTQFGTYECRLHLVASCYFIYDSKEVYNKRGCDNYFQVIYDSSGKVVGGLDNRVSPYTGNSGDTPTMQCDMIQLKPGRYSVRSSPRFLLMPERSYCFDMKEKGPVTAVQSIWGKDRKSDYAVDQACLSTPGCMLIQKQKPYTGEADDHHGDQEMRELLSGLDYEARCISQSGWVNETSPFTEEYLLPPKFGRCPLAAKEESIPKIPDGLLIPTSGTDTTVTKPKSRIFGIDDLIIGLLFVAIVEAGIGGYLLGSRKESGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEISPGCWIIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQSDPFYWGSSLGLAITAAISLAALVISGIAICRTK
What is the function of this protein?
Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.  Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase.  This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell (By similarity).
What are the official names of this protein?
Hemagglutinin-esterase-fusion glycoprotein, HEF.
What is the protein family that this protein belongs to?
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: ATX3_RAT
Sequence: MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERLRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIKVQQMHRPKLIGEELAHLKEQSALKADLERVLEAADGPGMFDDDEDDLQRALAMSRQEIDMEDEEADLRRAIQLSMQGSSRGMCEDSPQTSSTDLSSEELRKRREAYFEKQQHQQQEADRPGYLSYPCERPTTSSGGLRSNQAGNAMSEEDVLRATVTVSLETAKDSLKAERKK
What is the function of this protein?
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:17696782).  Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity).  Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity).  Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity).  Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (By similarity).
What are the official names of this protein?
Ataxin-3, Machado-Joseph disease protein 1 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: NAGB_CLOPE
Sequence: MRLIVTKNYEEMSKVAAKEMAEDIKRNPEIVLGLATGGTPVGMYKELIRMYNEGELDFSKVTSINLDEYVGLSGDHDQSYRYFMNTNLFNHINIDKNNTFVPNGLAENVEEECMAYDSRIQDMGGIDLQLLGLGANGHIGFNEPGEALSVGTHLTDLKESTIEANARFFDSIDDVPRKAITMGLGGIMKAKKIMVIASGEGKAEVVKAMMSGKITTEIPATMLQMHRDVILIVDEDAAKLLK
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: LSRD_SALPA
Sequence: MNPWRRYSWEIALAALLIFEILAFGVINPRLLDINVLLFSTSDFICIGIVALPLTMVIVSGGMDISFGSTIGLCAITLGVLFQLGMPLPLAIIITLLLGAICGLINAGLIIYTGVNPLVITLGTMYLFGGSALLLSGMAGATGYEGIGGFPTAFTDFANISFLGIPMPLIFFLVCCLFFWLLMHRTHMGRNVFLIGQSARVAQYSAIPVNRTLYTVYAMTGCASAIAAVLLVSYFGSARSDLGASFLMPAITAVVLGGANIYGGSGSIMGSALAALLVGFLQQGLQMAGVPNQISSALSGALLIVVVVGRSVSLHRHQILEWYSRRRNAHQA
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Autoinducer 2 import system permease protein LsrD, AI-2 import system permease protein LsrD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPA_SINFN
Sequence: MQTGSTLHDDRTSVSALGGLGARARGASGRLLPEIWMQNGAKRVEQALARLLCAEDHGETELMAAMRYATLHGGKRTRALLCLAAGALADTPAHILDDVGAAIEMMHACTLVHDDLPAMDDDVLRRGLPTVHVKFGEATAILVGDALQAHAFLTLASLDAPGDNRIALVRELAQAVSAEGAAGGQAMDLSLVGKHVELDRIVAMHRMKCGALVRASVRMGALCAIAEDAADATLYCALDHYSACFGLALQVVDDILDATADTATLGKTPGKDAAAQKPTCASIMGLQAARQFALDLLCEAGEAIAPLGPRAERLAQMLQRASAYLFKHAPSA
What are the official names of this protein?
Probable farnesyl diphosphate synthase, FPP synthase, (2E,6E)-farnesyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRDB_CALS8
Sequence: MNLEVEIAGVKLKNPVIAASGTFGFGREYSKLIDISEFGAICTKGITLKKRNGNPQPRLCEVYGGIINSVGLENPGVEAFVNEELPFLKGFNTKIIANINGFTKEEFVELTKVLSSLVDMIEVNLSCPNVKEGGMVFGKDPEKVYEITKSVKDVASCPIIVKLTPNVTDIAQLAIAAEKAGADAISLINTVSAMAIDIETRKPLIKMVTGGLSGPAIKPIAVRMVYECFKKVRIPIVGMGGIMNYKDAIEFFIAGATAIQIGTVNFINPKAVCEIKEGIEAYLERKGFNSIKELVGNINI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A1KA2_LOXAR
Sequence: WIMGHMVNAIAQIDEFVNLGANSIETDVSFDSSANPEYTYHGVPCDCGRTCTKWEHFNEFLKGLRKATTPGDSKYHEKLVLVVFDLKTGSLYDNQASDAGKKLAKSLLQNYWNNGNNGGRAYIVLSIPNLAHYKLIAGFKEALTSEGHPELMDKVGYDFSGNDDIGDVANAYKKAGVTGHVWQSDGITNCLLRGLDRVRKAVANRDSSNGYINKVYYWTVDKRQSTRDALDAGVDGIMTNYPDVVADVLNESAYKAKFRIASYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LarSicTox-alphaIB1aii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.