PharMolix/UniProtQA huggingface dataset:
Protein: PLP1_BORPE
Sequence: MKRIAMLAAACVIAVPAFAQNVATVNGKPITQKSLDEFVKLVVSQGATDSPQLREQIKQEMINRQVFVQAAEKDGVAKQADVQTEIELARQGILVRALMADYLQKHPVTDAQVKAEYEKIKKEQAGKMEYKVRHILVEDEKTANDLLAQVKSNKNKFDDLAKKNSKDPGSAERGGDLGWAPATNYVQPFAEAVTKLKKGQLVDKPVQTQFGWHVIQVDDTRPVEFPAMDQVRPQLEEMLRQQTLANYQKQLREQAKIQ
What are the official names of this protein?
Probable parvulin-type peptidyl-prolyl cis-trans isomerase, PPIase, Protein p13, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the PpiC/parvulin rotamase family.
Protein: K2C5_MOUSE
Sequence: MSRQSSVSFRSGGSRSFSAASAITPSVSRTSFSSVSRSGGGGGGRISLGGACGAGGYGSRSLYNVGGSKRISYSSGGGSFRNQFGAGGFGFGGGAGSGFGFGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTIKQNLDPLFEQYINNLRRQLDGVLGERGRLDSELRNMQDLVEDYKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEARVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSVSSGYGGGSSIGVGSGFGGGLGSGFAGGLGPRFTRGGGGLGLGSGLSVGGSGFSAGSSQGGMSFGSGGGSGSSVKFVSTTSSSRRSFKS
What is the function of this protein?
Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (PubMed:11408584).  Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (PubMed:19267394).
What are the official names of this protein?
Keratin, type II cytoskeletal 5, Cytokeratin-5, CK-5, Keratin-5, K5, Type-II keratin Kb5.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_ECOLU
Sequence: MKIYLVGGAVRDALLGLPVKDRDWVVVGSTPQEMLDAGYQQVGRDFPVFLHPQTHEEYALARTERKSGSGYTGFTCYAAPDVTLEDDLKRRDLTINALAQDDNGEIIDPYNGLGDLQNRLLRHVSPAFGEDPLRVLRVARFAARYAHLGFRIADETLALMREMTHAGELEHLTPERVWKETESALTTRNPQVFFQVLRDCGALRVLFPEIDALFGVPAPAKWHPEIDTGIHTLMTLSMAAMLSPQVDVRFATLCHDLGKGLTPPELWPRHHGHGPAGVKLVEQLCQRLRVPNEIRDLARLVAEFHDLIHTFPMLNPKTIVKLFDSIDAWRKPQRVEQLALTSEADVRGRTGFESADYPQGRWLREAWEVAQSVPTKAVVEAGFKGVEIREELTRRRIAAVASWKEQRCPKPE
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: CYSC_SHIF8
Sequence: MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: NHR5_CAEEL
Sequence: MSSGGNSSNVNRNSGSSNVITLNDSDEETEDSNLGSSSSTNLCKVCGAEKAALHYGALSCVGCKGFFRRALLKADQLECAANGECTVSVLQKTQCRSCRFNKCLREGMNPAYVRPNRDAPPKPRKPTTTVATCDQTDRGRTTKSREEWMKKMTVEMRTILMTLLNIETKVMKGDTQQEASKLYPLKGIDKLSDIIETPIQLKGKRTEMRYEAYRMAGNDELCAIAYRRLIAAIDWVESLSPLLGHLTPQDKIALVKSSFAPLMVFNFCARTAEACQDENVLCLCNFAYVPRNISKMYEDTYHLGNGLVERALNELVAVYREYGMREEEIVCVNAMICLNPLAKDVSDSLFEKIVELRNRIADCLFSIVKEVRLSPTPNVCYGHILLSLATVTELANAMSENLQFAQTFSNQGEIPLLTDLFGCFTVEPFFKEVDELAAMSLEKAKAEKKKEMSTQTDRLPPPRALLKRQATIDEDSEEPARQNFRLLQPPNNFYITEMLDDLRNNHAENHLISLNFDASNVSNAIASRPSFEDLGTVPSGSTVTRRIGSNIQGPSHLPQCGSTVTQRPTVPSSTTSSTFYNFPPPPGYPPLNAGYTPNVNYPNLYQQPQYFQNFQQNNYPSQVMEQQNYGNVESTSYPFPRNDGFVYNHPNIPYSHHNNSLQQNNFHNQYAN
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-5.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYOE_BUCAP
Sequence: MLKDYLEITKPRIIIGNIILIIGSFLFSSFPFFNVFLFFFTILGTSLVIASSCIFNNLIDIDIDTKMNRTKNRVLVKNLISPTSASIFASFIGIVGFFILGLFVNILSMFLSFIGFVIYVFFYTFFLKRKSMYSTFIGSFSGSIPSVIGHTAISNSIDLFCFLLFIIFIFWQMSHFYAIAILYINDYRKANLPFFPVVKGILKTKKHIFYYITCFIIASSMLTFLGYLSYIFLLFFSFFSFYWLYISYLSIREKDDRKFSSKLFYYSIAVVILFNFLISIDFIF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LMUB_BACC8
Sequence: MNKIIIRKLFIFDVIEKKAKSVDFEDGINIVTSKGNQLGKSTIMKSIYYTLGAEVFFADRLNVKSKIHMLETDVNDKKYTFIRHGDVVVIKDGKGIFKTSNASELSSKLHDIFGFSVFLEDKQKKYVIAPPVFRYIPYYIDQDHGWTSELKSFDKLGQFDKKSRDLLFYYHLNILDEDYGVKLKEKKELDASMTDLKTRKKEILGLLAYIRENITAFNLEMDITALQIQKREILNKYKKYSYDLNNIRRKILEYQEEIFKIDNVIDNLNSTLKQNDKVREHIKHQFDVECPYCNNHFEIQAKDILRINYNIVDLEASKLEMLDIKEKLLGKMKKVQKEYEDYQATLKAIEEEKVDSENTLEDILKFKGLQETQNQLNTELVKNTGDIEEKSEDLKEIRRDLKKWQDEIDKVNSRYKDILNLNLIRFNTNEHALPEKYNIGKNLKASGSGQVRVNLARVYSFIKLLEEYNPTGLKYPLVIDSPKGGEQSTTNSELILRLLTEKAQISNQIILATIDFESFYNGDTKKFNIISLENEPYHLLSAEDYQNNQVIIDDFVSLYFEANQ
What is the function of this protein?
Component of antiviral defense system Lamassu type II, composed of LmuA and LmuB.  Expression of Lamassu type II in B. subtilis (strain BEST7003) confers resistance to phage SpBeta (PubMed:29371424).  May be an ATPase (Probable).
What are the official names of this protein?
Lamassu protein LmuB, Putative ATPase LmuB.
Protein: PURQ_CHLCH
Sequence: MSAITVGVVVFPGSNCDHDTAYALASFAGVKPVMLWHNNHDLQGAQAIVLPGGFSYGDYLRAGAIARFSPLMKEVVEFARKGYPVLGICNGFQVLLESGLLEGALSRNRDKKFLCCQTTITPVNCSTRFTEDYHQGEVLRIPIAHGEGNYFAPPEVLESLQEHNQIAFQYCNAQGEVTVEANPNGSLLNIAGIVNRAGNVLGLMPHPERASDAALGSVDGRLLFESLFRSLTGV
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DFX_ARCFU
Sequence: MTEVMQVYKCMVCGNIVEVVHAGRGQLVCCGQPMKLMEVKTTDEGKEKHVPVIEREGNKVYVKVGSVAHPMEEQHYIEWIEVIDDGCVHRKQLKPGDEPKAEFTVMSDRVSARAYCNIHGLWQSG
What are the official names of this protein?
Desulfoferrodoxin homolog, Dfx.
What is the protein family that this protein belongs to?
Belongs to the desulfoferrodoxin family.
Protein: ISPE_NOCFA
Sequence: MLSVVPSPVLVRAPSKVNLHLGVGDLRPDGYHDLTTVFQALSLGDDLRISPASALTVKVNGEGAAEVPTDRTNLVWKAAVRLAHLVGRAPLVEIVIDKGIPVAGGMAGGSADAAAALVGLNELWDMGLGRDELSALAAELGSDVPFALHGGTALGTGRGERLLPVLSRNTFHWVLAFAKGGLSTPAVFAELDRLREHGDPPRLGDPQALMQALASGDPAQLAPLLGNDLQAAAVSLKPELRRTLRAGVTAGALAGLVSGSGPTCAFLCESADAAVAVAAELAGAGVARSVRTASGPVPGARVIDPES
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RELX_ECOLX
Sequence: MRYQVKFREDALKEWQKLDKAIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGKRERSDVYNLASERMR
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Putative RelE-like toxin protein.
What is the protein family that this protein belongs to?
Belongs to the RelE toxin family.
Protein: COAD_LEPBL
Sequence: MKHLAIYPGSFDPLTNGHLDILQRSLGLFDKVIIAIAVNSNKSTLFSIEERLEFIHKVTQGLKGLEIDTFQGLTVDYCNKVGANSIIRGLRAVTDFDYEYAISLMNKKLAPNVETVFLMSSGEYSFISSTIVKEVARHGRDVSNQVPEIVGKALLKKLSQ
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_GEOSE
Sequence: MKLQIPAGKANPAPPVGPALGQAGVNIMAFCKEFNARTADQAGLIIPVEITVFEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATIKRDKVREIAELKMPDLNAASIEAAMRMIEGTARSMGIVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: DNAT_SALPA
Sequence: MSSRILTSDVIGIDVLLHDHHAVLAKSTGGAVAVFANNAPAFYAVTPARMAELLALEEKLSRPGSDVALDAQFYEEPEAAPVAIPCGKFAMYPAWQPDADFQRQAALWGVALREPVTAEELAAFIAYWQAEGKVFHHIQWQQKLARSVQISRSSNGGMPQRDINSVSEPDNHIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: SOFL2_ARATH
Sequence: MESPRIHGGAEEKSSCESGWTMYIEDTFHGNHHSEVVYEEEDDGFSVKEVDDDGDGDEDDDDDDDDDSSNNESDDSMTSDASSWPSTHQPPRSTKNHAAAKNSNAKQVNNQTENRVRDRFSDEGEESELKARTRTTAASRVKVSKTK
What is the function of this protein?
Involved in cytokinin-mediated development (PubMed:20011053, PubMed:29467189).  Together with SOFL2, triggers the endogenous content of specific bioactive cytokinins derived from the biosynthetic intermediates trans-zeatin riboside monophosphate (tZRMP) and N(6)-(Delta(2)-isopentenyl)adenosine monophosphate (iPRMP) such as N-glucosides trans-zeatin 7-glucoside (tZ7G), cis-zeatin 7-glucoside (cZ7G) and N(6)-(Delta(2)-isopentenyl)adenine 7-glucoside (iP7G) (PubMed:20011053).
What are the official names of this protein?
Protein SOB FIVE-LIKE 2, AtSOFL2.
What is the protein family that this protein belongs to?
Belongs to the SOFL plant protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS15_PARL1
Sequence: MSITPERKAQLIKEFAGKDGDTGSPEVQVAILTERIVNLTEHFRGHAKDNHSRRGLLKMVSQRRSLLDYVKKKDQARYEKLISRLGIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: TUSB_SALCH
Sequence: MLHTLPHCASSVDFPALLRLLKEGDALLLLQDGVTVAIEGNRFLESLRDAPITVYALKEDIDARGLGGQISDSVVRVDYTEFVRLTVKYANQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_STRA3
Sequence: MNELIKHKLELLPDSPGCYLHKDKNGTIIYVGKAKNLKNRVKSYFHGSHNTKTELLVSEIEDFEYIVTTSNTEALLLEINLIQENMPKYNIRLKDDKSYPYIKITNERYPRLMITRQVKKSDGTYFGPYPDSGAATEIKRLLDRLFPFKKCTNPANKVCFYYHLGQCNAHTVCQTNKAYWDSLREDVKQFLNGKDNKIVNGLTEKMKSAAMTMEFERAAEYRDLIEAISLLRTKQRVIHQDMKDRDVFGYFVDKGWMCVQVFFVRNGKLIQRDVNMFPYYNEPEEDFLTYIGQFYQDTKHFLPKEVFIPQDIDAKSVETIVGCKIVKPQRGEKKQLVNLAIKNARVSLQQKFDLLEKDIRKTHGAIENLGNLLNIPKPVRIEAFDNSNIQGTSPVAAMVVFVNGKPSKKDYRKFKIKTVIGPDDYASMREVIHRRYSRVLKDGLTPPDLIVIDGGQGQVNIARDVIENQLGLAIPIAGLQKNDKHQTHELLFGDPLEVVELPRNSEEFFLLHRIQDEVHRFAITFHRQLRSKNSFSSKLDGITGLGPKRKQLLMKHFKSLPNIQKAEIEDIIMCGIPRTVAESLRDSLNDPPK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIP_ALLVD
Sequence: MSDKPISKSRRDAVKVMLGTAAAIPMINLVGFGTARASAPANAVAADDATAIALKYNQDATKSERVAAARPGLPPEEQHCANCQFMQADAAGATDEWKGCQLFPGKLINVNGWCASWTLKAG
What is the function of this protein?
Specific class of high-redox-potential 4Fe-4S ferredoxins.  Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.
What are the official names of this protein?
High-potential iron-sulfur protein, HiPIP.
What is the protein family that this protein belongs to?
Belongs to the high-potential iron-sulfur protein (HiPIP) family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS21_DROGR
Sequence: MENDAGENVDLYVPRKCSASNRIIHAKDHASVQLSIVVVDPETGRQTDGTKTYAICGEIRRMGESDDCIVRLAKKDGLITKNF
What is the function of this protein?
May be an associated component of the ribosome rather than a core structural subunit.  May act as a translation initiation factor.  Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva (By similarity).
What are the official names of this protein?
40S ribosomal protein S21, Overgrown hematopoietic organs at 23B.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS21 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: PXPA_BACC1
Sequence: MTTIDLNCDLGESFGAYKMGNDDEILPFVSSINVACGFHAGDPSVMRQTVEKALQHNVAIGAHPGFPDLIGFGRRNMNVSASEVYDYVLYQIGALDAFVKAAGGKMQHVKPHGALYNMAATNPEIADAIAKAIYHSNPNLLLYGLANSEAFIQAAEKYNITLVQEAFADRTYKQDGTLTSRTEENALIKNEDEAIKQVLQMVKEGYVNSVNGEKVEVQAKTICLHGDSEKAVQFAERIYRTFELNGISICAPK
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: MINC_BACC2
Sequence: MEEKKQQNVTIKGTKDGITLHLDDCCSFSELLIELDEKLSTHYYDGDGRSLIEVHVKVGNRYLTEVQQEEIRTLIRNKKNLVVDSIKSDVITKAEAIAWKEETEIVPISKIVRSGQVLHVKGNLLLIGDVNPGGTVIAGGNIFVVGSLRGIAHAGYYGDSDAVIAASVMNPMQLRISDVAMRAPEEKEDGAEAAECAYINENNHIVVDRLQLLTHLRPNLTKLERGIV
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: ENO_HYPNA
Sequence: MSEIIDIHAREILDSRGNPTIEVDVTLDDGSTGRAAVPSGASTGAYEAHEQRDGDKARYNGKGVLKAVDAVNGEICNELAGMDATEQRLVDTLMIDLDGTENKSRLGANAILGVSLAVAKAAAESSALPLYRYLGGANARILPTPMMNIINGGAHADNPVDIQEFMIMPVSAESISEAVRMGAEVFHALKKTLHDAGHNTNVGDEGGFAPNLASADEAIGFIMKSIEKAGYRPGEDIALALDAASTEFYKNGKYELAGEGKSLSSEQFGQYLADLCGRYPILSIEDGMAEDDWDGWVALTELLGDRVQLVGDDLFVTNPDRLAIGLQKGAANSILVKVNQIGTLSETLDAVELAHLHGYTAVMSHRSGETEDSTIADLAVATNCGQIKTGSLSRSDRIAKYNQLIRIEEELGPIGMYAGLARINAG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SECA_DESPS
Sequence: MIGKMLTKVFGSKNDRVLKQIRPLVTRINDLESTIKPLGDAALVAKTVEFKERIAKGESLKDLLPESFAVMREAASRVLGERHYDVQLVGGIILHKGRIAEMKTGEGKTLTSTLPVYLNGLSGKGVHVVTVNDYLAARDAEWMGQVYDFLGMSWDKIIHGMDDVERRAAYAADITYGTNNEFGFDYLRDNMKFELDDFCQRGFNFAIVDEVDSILIDEARTPLIISGPAEMSTELYDNINSIMYNFKVEEHYTVDEKARTVSLTDDGIGLGEELLDLENLCDPSSIEQLHHLNQALKAHVLFQRDVDYIVNDGQVVIVDEFTGRTMEGRRYSDGLHQALEAKENVKVEQENQTLAAITFQNYFRMYDKLAGMTGTADTEAAEFKKIYDLDVVLMPTNQPMVRDDYADVIFKNEDAKYRAVVREIAEMHEKGRPVLVGTISIDVSEKIADMLTKAKVPHEVLNAKQHAREAEIITAAGQVGRVTIATNMAGRGTDIKLGEGVRELGGLHIVATSRHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDDLLRIFGSGRVSGIMDKLGMEEDEPIEHGMISRAIENAQRKVEGHNFDIRKHLLEYDDVMNKQREIVYQQRYEVLAGADVSAEIQEMVNDIVRNLASEFSDERLDSLDWDWAGCLERLQEAFSVQPEWSEETRTDIKFEELRDLIAGVVAQKYREQEEENGADTQRQLEKILLLQVVDGLWKDHLLSMDYLKEGIGLRGYGQKNPLNEYKREAFQLFGHLMETVKSQVVSSLMRVRVVHENDVDRMEEERRRRHEEEMQRIQALVPAGNADEEHQQPAHVDKIGRNTPCPCGSGKKYKKCCGKLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: DDL_PELUB
Sequence: MTKKILILSGGISKERLISLDTGKQVAKELIKNGYKVLISEPDKNLSKNITSFKPDVIFNALHGQFGEDGYIQAILETKKIPYTHSGVIASSIAMDKEISKKIFIKNKILTPKYIKFNHKKNKLNIIKLIEKNLKFPVVVKPINEGSSVHVYICDKTNILKNLKVLKSYNEILIEEFIPGREIQVAIMNNKSLGAIELEPRRKFYDYEAKYNSSAKTKHLIPVDLSKNNLAKITGIARAAHKIIGCKGVTRSDFKFFNGKFYLLEINTQPGMTKLSLVPEIAKHKGISFIKLIEWILKDASINR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTYF_ASPRU
Sequence: MLATDSTPALLAASVVLAVSLVSYVIQLNRSRTHRAFWASHPWVGVRDEWFSGARTKLRIVTSVREMVEDGFHRFSQFKTAFALPNIGEPPWLVLPPASLREFLAKPDADLDHNIIHEEQLQNYYTQGALGHHAATIPLQFDVVRRQLTRELPLVAAALHDELHKSFQDYWGTDTIAAKQIDLLATCFKIVTRTANRVFIGADICRSEAFLEHLRRYSDAVGRAGIIIRLFPRWLRPVVTPAVTVWYRRDLAVCREICVPVIRCRVQQTIEKRKDVDCTWKAPVDVLQWLIEAALRRNDAAELDPLLLTQRLLMLNFVSIETTSMAITHAIADLYGSADADSFIAGLQEECERALPHGELWTKAQLDNLVRIDSAIRESMRVSDFSHIQLPRLVANPHGVDFQSTGNPPLHVPPGIRLCVPAHSIHRDPALYPDPLTYNAFRFVIEPSVGAGDATEPAPKQASLATTTDSFLVFGHGRHACPGRFFAAHLMKLMLAYIVRHYDVARLTQPVDKQTTECTKAPFHMEYGGGPLAYMGHSLTGATRLQDTLCFMKFDSSQYLDTSPIVTIPSYIYWPSLNTMNQSSKYSLYVFVVLVACVAALFIGIGIYQMYHPLDRDNAAYREVPHEQRAYMRKAGSPPAFSKFIYRLYCPNIQWKVKRCIGVLFLLFAYYNSRLRLSSATKN
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the de novo generation of L-homotyrosine from acetyl-CoA and 4-hydroxyphenyl-pyruvate (PubMed:22998630).  L-homotyrosine is a building block of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent (PubMed:22998630).  L-homotyrosine 4-hydroxyphenyl-pyruvate first undergoes an aldol-type condensation by htyA with the C-2 of acetyl-CoA followed by the release of CoA to form 2-(4-hydroxybenzyl)-malate (PubMed:22998630).  This is followed by isomerization of 2-(4-hydroxy-benzyl)-malate to 3-(4-hydroxybenzyl)-malate by htyD (PubMed:22998630).  Thereafter, 3-(4-hydroxybenzyl)-malate undergoes decarboxylation and oxidation to form 2-oxo-4-(4-hydroxybenzyl)butanoic acid, coupled to reduction of NAD(+) to NADH by htyC (PubMed:22998630).  The product then undergoes transamination catalyzed by htyB to form L-homotyrosine (PubMed:22998630).
What are the official names of this protein?
Cytochrome P450 monooxygenase htyF, L-homotyrosine biosynthetic cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MDH_MORS2
Sequence: MKVAVLGAAGGIGQALALLLKTQLPAGSELSLYDIAPVTPGVAVDLSHIPTDVTITGFSGIDPTAALVGADVVLISAGVARKPGMDRSDLFNINAGIIKNLASKCAEVCPTACIGIITNPVNTTVPIAAEVLKQAGVYDKRKLFGITTLDVIRSETFVSALKGISLADVAVPVIGGHSGATILPLLSQVKGVEFTAEEIATLTTRIQNAGTEVVEAKAGGGSATLSMGHAAARFGLSLVRALQGEKGIVECTYVDGGSEHATFFAQPVLLGKNGVEEVLAYGDLSDFETNARDAMLEELKANITLGEEFVAG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: KTHY_AERHH
Sequence: MSKFIVIEGLEGAGKSSAVRYVADYLHGHGVARIECTREPGGTPLAERMRAIVKEVHDERLTIEAELLLMYASRVQLVETRIKPALADGIWVVGDRHDLSSQAYQGGGRGIDANLIGAIKRAVLGDFKPDLTLYLDIDPAIGLQRARHRGELDRIELEQLSFFERTRQRYLELAAADESIKVIDAGQAPEQVKAAIEAALAHYLKDEPSCIPG
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.