PharMolix/UniProtQA huggingface dataset:
Protein: COBS_SHESM
Sequence: MSERESWHKEIDLFLVAMGYFTRIPMPKWVEVDADKLNKASRYFGLVGLLVGLLSAIVFWLTQNWLPAGVSVLLSMVTGVLLTGGFHEDGLADTFDGFGGGWTAEDKLRIMKDSRLGSYGALALMLVLMLKWQLLVELALYDPVVAGSAMIVAHTVSRVVAASLIFTEKYVRDDESSKSKPLAQHQGINELFILIASGVLVLLVLKGIAALSLLLVMIGLRRLIVVIFRRQIGGYTGDTLGAAQQICEIVCYFVLLVVGSIL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAA_RHOJR
Sequence: MNDDPNALARIWIDVVADLTSDSPGGDLPPLTRGQKAWLALVKPLTLAQGFALLSVPSPFAQEAIERDLREPILHALGRHLGEQVEGLGVRIAAPVDDEPESDPPSRDHRPEPEPLHTPRHLEPSVTSSGSFRRRRFGSGEDQPYSDTTDFEEVDDDREALASVHESWPSYFTKPPSGPAPSATGGNSLNAKYTFDTFVIGSSNRFAHAAAVAIAEAPARAYNPLFVWGASGLGKTHLLHAAGHYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRRYRETDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVVSSDRPPKQLATLEERLRTRFEWGLITDVQPPELETRIAILSKKARMDRLEVPDDVLELIASRIERNIRELEGALIRVTAFASLNRQPLDLTLAEVVLRDLMPDSSSLEINAATIMAVTAEYFNMSIDDLCGPGKARPLASARQISMYLCRELTDLSLPKIGQTFGRDHTTVMYADKKIRKEMTERRKVYDQVQELTARIKQRSKR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STP2_MOUSE
Sequence: MDTKMQSLPTTHPHPHSSSRPQSHTSNQCNQCTCSHHCRSCSQAGHAGSSSSPSPGPPMKHPKPSVHSRHSPARPSHRGSCPKNRKTFEGKVSKRKAVRRRKRTHRAKRRSSGRRYK
What is the function of this protein?
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:15163613, PubMed:15189834, PubMed:15083521, PubMed:28366643).  In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643).  The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP2 onto chromatin (PubMed:28366643).
What are the official names of this protein?
Nuclear transition protein 2, TP-2, TP2.
What is the protein family that this protein belongs to?
Belongs to the nuclear transition protein 2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Loaded onto the nucleosomes of condensing spermatids (PubMed:28366643). Inclusion of the H2AB1- H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition protein TNP2 (PubMed:28366643). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity).
Protein: Y041_MYCTA
Sequence: MVAPHEDPEDHVAPAAQRVRAGTLLLANTDLLEPTFRRSVIYIVEHNDGGTLGVVLNRPSETAVYNVLPQWAKLAAKPKTMFIGGPVKRDAALCLAVLRVGADPEGVPGLRHVAGRLVMVDLDADPEVLAAAVEGVRIYAGYSGWTIGQLEGEIERDDWIVLSALPSDVLVGPRADLWGQVLRRQPLPLSLLATHPIDLSRN
What are the official names of this protein?
UPF0301 protein MRA_0041.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: ORN_XANC8
Sequence: MADNVAGNDRLIWIDLEMTGLDTDRDSIIEIATIVTDAQLNVLAEGPELAIAHSLETLEAMDEWNRNQHRRSGLWQRVLDSQVTHAQAEAQTVAFLSEWIRAGASPMCGNSICQDRRFLHRQMSRLERYFHYRNLDVSTIKELARRWAPAVASGFAKSSAHTALSDVRDSIDELRHYRQFMGTLGGDNGGGVQN
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_STAAC
Sequence: MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_HALOH
Sequence: MSVLAEQYKEEIVPKLMDKFDYENIMAVPRVEKVVVNVGMGELKEDPKLIDVVVNDIASITGQKPVITRAKKSVANFKIREGMPIGAKVTLRGETMYEFLYKLVNVTLPRIRDFRGVSPKSFDGRGNYNIGIREHIVFPEIEIDKVDKVYGLEITIVTSAETDEEAYELLKLMGMPFNQ
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: DAPF_ACIBC
Sequence: MLLEFTKMHGLGNDFMVVDLISQRAYLDTATIQRLADRHFGVGFDQLLIVEPPDVPEADFKYRIFNADGSEVEQCGNGVRCFARFVHERHLTNKTNITVQTKAGIVKPELGQNGWVRVNMGYPKFLPNEIPFVAEEPKALYTLELANDQNISIDVVNMGNPHAVTIVPDVLTADVAGIGPQVESHKRFPERVNAGFMQVIDDKHVRLRVFERGVGETLACGTGACAAAVSGMRRGLLANSVEVELAGGKLQIEWQEGDVVWMTGPTTHVYDGRLDLRYFQG
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EAPP_MOUSE
Sequence: MNRLQDDYDPYAVEEPSDEEPALSSSEDELDVLLHGTPDQKRKLIRECLTGESESSSEDEFEKEMEAELNSTMKTMEDQLSSLGTGSSSGVAKVGGVTEKFYDEIYFDSDSEDEDKTVTKKKKKKQHRIPTNDELLYDPEKDNRDQAWVDAKRRGYHAFGLQRPRQKQQPVPNSDAVLNCPACMTTLCLDCQRHESYKTQYRAMFVMNCSINREEVLRYKNPENRRKRRSAKKMRSNPEDPAEREAEEIYHPVMCTECSTEVAVYDKDEVFHFFNVLASHS
What is the function of this protein?
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis.  Promotes S-phase entry, and inhibits p14(ARP) expression (By similarity).
What are the official names of this protein?
E2F-associated phosphoprotein, EAPP.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL24_ACIAD
Sequence: MAKIKKGDQVIVIAGKEKGKQGTVLSVSEDRVKVEGLNLVKKHQKPNRVTGAEGGIVTQEASLHISNVAVFNATTQKADRVGYQVDENGAKTRVYKSNGESVAVAK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PXPB_BACSU
Sequence: MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFPGFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIVEIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRIAAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRAGDIVKFVRISEKDYHAYKEESN
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate (PubMed:28830929).  In addition, is a potent inhibitor of the autophosphorylation reaction of kinase A (kinA) and its reverse reaction, but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated.  Is an inhibitor of the catalytic domain of kinase A affecting the ATP/ADP reactions and not the phosphotransferase functions of this domain.  The inhibition is non-competitive with respect to ATP (PubMed:9334321).
What are the official names of this protein?
5-oxoprolinase subunit B, 5-OPase subunit B, 5-oxoprolinase (ATP-hydrolyzing) subunit B, Antikinase KipI, Kinase A inhibitor, Sporulation inhibitor KipI.
What is the protein family that this protein belongs to?
Belongs to the PxpB family.
Protein: CAIB_ECO7I
Sequence: MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKVRETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLYKCADGYIVMELVGITQIAECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLAAHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKGPNIMPKFKNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED
What is the function of this protein?
Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine.  Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.
What are the official names of this protein?
L-carnitine CoA-transferase, Crotonobetainyl-CoA:carnitine CoA-transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. CaiB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2A2B_HUMAN
Sequence: MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTESHKPGKNK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A type 2-B, H2A-clustered histone 21.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DTX42_ARATH
Sequence: MMSEDGYNTDFPRNPLYIFFSDFRSVLKFDELGLEIARIALPAALALTADPIASLVDTAFIGQIGPVELAAVGVSIALFNQVSRIAIFPLVSITTSFVAEEDACSSQQDTVRDHKECIEIGINNPTEETIELIPEKHKDSLSDEFKTSSSIFSISKPPAKKRNIPSASSALIIGGVLGLFQAVFLISAAKPLLSFMGVKHDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGDVTNIILDPIFIFVFRLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHLQFCRFMKNGFLLLMRVIAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASDFGYAAASLVMVAIVSILCLLFLSSTHGFIGLWFGLTIYMSLRAAVGFWRIGTGTGPWSFLRS
What is the function of this protein?
Citrate transporter critical for aluminum tolerance.  Responsible for citrate exudation into the rhizosphere to protect roots from aluminum toxicity.
What are the official names of this protein?
Protein DETOXIFICATION 42, AtDTX42, Aluminum-activated citrate transporter, AtMATE, FRD-like protein, Multidrug and toxic compound extrusion protein 42, MATE protein 42.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISPH_TRIEI
Sequence: MDTKAFTRALKKSENYNRQGFGHAQEVATLMQSAYKSNLIQQIRENNYTLQRGEVTIKLAKTFGFCWGVERSVAMAYETRQHFPNQQIWISYELIHNPSVNQDMKDMEIKFIPVIDGQKDFSVAGNNDVVILPAFGASVQEMQILKDKNCQIVDTTCPWVSKVWNSIEKHKKKKFTSIIHGKYSHAETIATSSFADKYLIVLNMTQAQYVCNYILNGGNRDEFLAKFKQAYSEGFDPDLDLEQVGIANQTTMLKTETEEIGKLFERTMMKKYRPDQLNAHYQNFNTICDATQERQDAIAGLFNEKLDLMVVIGGFNSSNTTHLQEMAIENGIPSYHIDGAQRILSRNKIEHKPLGREVKISEGWLPEGPVVVGLTSGASTPDQAVEDTINKIVAMKLVVMN
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: CN028_BOVIN
Sequence: MKTLFEEIKASIKNNYNQDRSFWRPVLPWGGVFTIKAGRKAVSCTPLYVEIRLKNTCTIDGFLMLLYVILNENENFPRELSLHLGREFVDCFLYLMDTYSFTTVKLLWIWDKMEKQQYKSEVHKASLIIDLFGNEHDNFTKNLENLMSTIQESYCSNWRCPTRVQEDQQRTINIKCGGLREFSQRVFCHGAPPFVVLNMQHWKSEDLAYVPYYLDLSDHKYLLEGATLFNKEEHHYSAAFQIDGHWMHYDGLRNVNLILLNKPPEFLLLSSLVYIRATEK
What are the official names of this protein?
Uncharacterized protein C14orf28 homolog.
Protein: TRPR_SHIFL
Sequence: MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3196_ALTMD
Sequence: MKLIIISGRSGSGKSVALRALEDLGYYCVDNIPVNLLPTLTHTVVDEYDQVAVSIDVRNLPKNPDDLVEILDYLPSSWSMTIVYIDASDDVLVKRFSETRRLHPLAKLNKSLSEAIRAESALLAPIAERADLYLDTDKLTIHQLAELIRERILGKKSSRLVLVFESFGFKHGIPKDADYVFDARFLPNPHWEPDLKHLTGLDAPVEVFLGSQPVVTKFIWQIQNLITTWLPHLERNNRSYVTVAIGCTGGQHRSVYIAQTLSKTFSEIHPDVQIRHRELNQ
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein MADE_1004170.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: H4_ASCSU
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRSVLKVFLENVIRDAVTYCEHAKRKTVTAMDVVYALKHQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: FANH_ECOLX
Sequence: MIKKVPVLLFFMASISITHASQTATKSLGVSITLSKAQCKINNRAGISGSFVLPMISTSGQIISSKKFTTVPIIIDCTAGGNVNQLEITFGDNSSKKIDSTTWYTTNKDLGLRFSWTKDKTQGFNLGVAHNINKSIWLEGNKKFNASVDVSPVVIRNTVQGGQYTSALPVTVTFI
What is the function of this protein?
Involved in the biosynthesis of K99 fimbriae.
What are the official names of this protein?
Protein FanH.
What are the subcellular locations of this protein?
Fimbrium.
Protein: NMNA2_CAEEL
Sequence: MKRVALLAVGSFNPPTIAHLRMLEVARSHLETINTQVVEGIMSPVADSYNNKPTLIKSNFRIQMVRAATKSSDWIRADDWECTRTTWTRTIDVLRHHRELVQEKFGSDVGMMLVVGGDVVDSFTRILPDGSNLWNSSDIRTIITEFGLIVLSREGSNPLNTIQSMPAISEFCDRIIQVKDEVCPSGVSSTRLRAAIMNKKSIKYSTPDEVINFIRENNLYQKI
What is the function of this protein?
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP.  Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate.
What are the official names of this protein?
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2, NMN/NaMN adenylyltransferase 2, Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic NMN adenylyltransferase family.
Protein: FAL1_PICGU
Sequence: MDFDRELDEELEFTKSTKKVKIYPTFESMNLKPELLKGIYNYGFEAPSAIQSRAIMQIIRGRDTIAQAQSGTGKTATFSIGILSSIDTKSKDCQALVLSPTRELAQQIENVIEHLGDYMNVRSHACIGGTQVGEDVKKLQQGQHIISGTPGRVLDMIKRRNIMPRHVKMLVLDEADELLTKGFKEQIYEIYKTLPAGAQVVVVSATLTPEVLEMTNKFTSDPVKILVKRDDVTLKGIKQYYIQCEKEDWKFDTLCDLYDNLTITQAVIFCNTKAKVNWLAGQMRKSNFTVAAMHGDMKQEDRDSIMKEFRSGSTRVLISTDVWARGIDVQQVSLVINYDLPLDKENYVHRIGRSGRFGRKGTAINLLTSQDKDELKSLQHYYSTKIREVPADLSKIM
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase FAL1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PGK_THESM
Sequence: MFRLSDFNYHDKVIFLRADLNSPVKDGKIISDARFRAVLHTIRYLLEHKAKVVIGTHQSKPYEEDYLTTEQHAEILSSLLGVKVKYVDDIFGKCARDAIKALKPSEVLMLENLRFAAEETKQNPLEYCERTHFVRKLSPLIDYVVNEAFAAAHRSQPSLVGFARIRPMIPGFLMEKEIKALTRAYESLERPKIYVLGGAKVEDSLNVAENVLRNEKADLILTGGLVGHVFTLAKGFDLGDANISFLDEKGLIKLVDRAEIILNEFYPYIRTPVDFAVEYKGERVEIDLLSDKQWIFDERPILDIGSRTIEKYSEILKEASIIVANGPMGVFEIEEFAKGTVEVFKAIGESKAFSIVGGGHSIASIYQYNIKGISHISTGGGAMLTFFAGQSLPVLQALKISYEKFKNKKELNQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRTF_ASPCI
Sequence: MAPALPFALPSLAGKVYLVTGGNTGVGFHTVDELAKHGARVYMGARSPGKAEAAIKTIRAETPTADVHFLQMDLMDLHSVVAAAKSFKEKETKLHGLVNNAGIMATPYALSGDGFEAQWQTNYLSHWVLTWHLLDVLVRTLQAEGGAAGSVRVVDVTSDGHNFAPKVGIDFKDINLEKAGVFARYGQSKVGNILHAKQLNKLYGPSGSETAKKGIWTAAVHPGHLDTNLNKQTAFPKFVNTLLRAVGAYSPPRDGAFNSVFAVASPEFKVADSGEYFVPGQKKKQPSKVARDMELAGRLWKWTEEELRKRELLD
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of various drimane-type sesquiterpene esters, compounds that exhibit diverse biological activities and are widely present in eukaryotes (PubMed:34468074).  The pathway begins with the synthesis of the backbone drimenol by the terpene cyclase drtB using farnesyl pyrophosphate (FPP) as substrate (PubMed:34468074).  The cytochrome P450 monooxygenase drtD is then responsible for the hydroxylations at C-6, C-9 and C-12, as well as the oxidation of hydroxyl groups at C-6 and C-11 to a ketone and an aldehyde, respectively (PubMed:34468074).  Then, the biosynthesis can go in two directions, either the hydroxylated drimenol is further hydroxylated at C-2 and C-3 by an enzyme(s) not associated with the drt cluster, or the FAD-binding oxidoreductase drtC further oxidizes C-11 or C-12 to form the butyrolactone ring (PubMed:34468074).  DrtB, drtD and drtC are solely responsible for the formation of the different drimane structures observed during drimane sesquiterpenes biosynthesis (PubMed:34468074).  The polyketide synthase drtA synthesizes different lengths (C6 and C8) of PKS chains, which are then oxidized to varying degrees by the short-chain dehydrogenase drtF (PubMed:34468074).  Finally, these PKS chains are transferred onto drimane sesquiterpenes by the acyltransferase drtE, forming the sesquiterpene esters (PubMed:34468074).  In addition to the different fatty acyl-CoA chains produced by drtA, drtE is also able to use cinnamoyl-CoA as a substrate (PubMed:34468074).
What are the official names of this protein?
Short-chain dehydrogenase/reductase drtF, Drimane-type sesquiterpene ester biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: NCAP_BRV1
Sequence: MNSMLNPNAVPCQPSPQVVAIPMQYPSGFSPGFRRQRNPGFRPMFNRRRNNNGNQNRGRQNRQRVQNNNRGNIRNRQNNGQRGNRRQYNQPSPNVPFEQQLLMMANETAYAATYPPEMQNVAPTKLVKIAKRAAMQIVSGHATVEISNGTEDSNKRVATFTIKVVMN
What is the function of this protein?
Major structural component of virions that associates with genomic RNA.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
What is the protein family that this protein belongs to?
Belongs to the torovirinae nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Note=Located inside the virion, complexed with the viral RNA.
Protein: FOLD_STRT2
Sequence: MAIIMDGKALAVNMQEQLQEKVARLKEKEWIVPGLVVIMVGENPASQVYVRNKERAAKKAGFHSKTVNLSESISEEELIEVIEKYNQDPLFHGILVQLPLPNHISEMRILLAIDPKKDVDGFHPMNTGNLWNGRPQMVPCTPAGIMEILREYNVELEGKTAVIIGRSNIVGKPMAQLLLEKNATVTLTHSRTPHLAKVCNKADVLIVAIGRAKFVTEEFVKEGAVVIDVGINRDEEGKLCGDVDFDQVKEKVSMITPVPGGVGPMTITMLMEQTYQAALRSLKG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CHID1_MOUSE
Sequence: MWPLLHVLWLALVCGSVHTTLSKSDAKKAASKMLLEKTQFSDKPVQDRGLVVTDIKAEDVVLEHRSYCSSRARERNFAGEVLGYVTPWNSHGYDVAKVFGSKFTQISPVWLQLKRRGREMFEITGLHDVDQGWMRAVKKHAKGVRIVPRLLFEDWTYDDFRNVLDSEDEIEELSKTVAQVAKNQHFDGFVVEVWSQLLSQKHVGLIHMLTHLAEALHQARLLVILVIPPAVTPGTDQLGMFTHKEFEQLAPILDGFSLMTYDYSTSQQPGPNAPLSWIRACVQVLDPKSQWRSKILLGLNFYGMDYAASKDAREPVIGARYVQTLKDHRPRVVWDSQAAEHFFEYKKNRGGRHVVFYPTLKSLQVRLELARELGVGVSIWELGQGLDYFYDLL
What is the function of this protein?
Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization.  Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity).
What are the official names of this protein?
Chitinase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
What are the subcellular locations of this protein?
Secreted. Lysosome.
Protein: RT12_YEAST
Sequence: MLSRFMSNTWCTPLRQAQRLFSSTTTMQATLNQIKRGSGPPRRKKISTAPQLDQCPQRKGVVLRVMVLKPKKPNSAQRKACRVRLTNGNVVSAYIPGEGHDAQEHSIVYVRGGRCQDLPGVKYHVIRGAGDLSGVVNRISSRSKYGAKKPSKS
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081).  uS12m is required for respiratory growth (PubMed:11780787).
What are the official names of this protein?
37S ribosomal protein S12, mitochondrial, Mitochondrial small ribosomal subunit protein uS12m.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.