PharMolix/UniProtQA huggingface dataset:
Protein: EF2_METMP
Sequence: MGRRAKMVEKVKTLMETHEQIRNMGICAHIDHGKTTLSDNLLAGAGMISKELAGDQLALDFDEEEAARGITIYAANVSMVHEYSGKEYLINLIDTPGHVDFGGDVTRAMRAIDGAVVVCCAVEGVMPQTETVLRQALKEKVKPVLFINKVDRLINELKLTPEELQGRFMKIIAEVNKLIEKMAPEEFKKEWLCDVANGKVAFGSAYNNWAISVPYMQRSGISFKDIIDYCEQENQKELAEKAPLHEVVLDMSIKHLPNPLTAQKYRIPNIWKGDAESTIGKSMVACDPNGPLAGVVTKIIVDKHAGAISACRLFSGRIKQGDDLYLVGSKQKARAQQVSIFMGAERVQVPSISAGNICALTGLREATAGETVCSPSEILEPGFESLSHTSEPVITVAIEAKNTKDLPKLIEILRQIAREDNTVRVEINEETGEHLISGMGELHIEVITNTKIGRDGGIEVDVGEPIVVYRETIMGTSPEIEGKSPNKHNKLYMIAEPMEESVYAAYVEGKLHDEDYKKKTTADGEARLVEAGLEKDQAKKVMSIYNGNMIVNMTRGIVQLDEARELIIEGFKEGVRNGPLAAEKVQGVKIRLVDATFHEDAIHRGPAQIIPAVRFGVRDAVAQAKPVLLEPMQSVYINTPQDYMGDGMKEINNRRGQILDMEQEGDMSIIKSSVPVAEMFGFAGAIRGATQGRCLWSVEFSGFERVPNELQPKIAKQIRDRKGLKSE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_METBF
Sequence: MRGKLITLEGIDGSGKSTVAEKLQKNPEIKAFKPVFTREPTRGTLTGDAVEKAIQSDTDQFAELFLFTADHAEHLAKLIKPALENGKIVISDRYSDSRYAYQGITLKTRLENPLEWVKDLHRSWTIVPDLTFLFDIRPEISIERCGKRGEQSKFEKLEFLQGVRAIFLKLAADDPERFVVIDASRSPEYIEKEVVKKILEFLSRN
What are the official names of this protein?
Probable thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SIDG_ASPFU
Sequence: MTIKAQPTLHTARLELVPLGHEHREFTMKLDMDPEVMKMVAFGRPFTEDEAIQVHTWLMNCATSVPGFGTWVGFAEGEFVGWWVLAPVPTTENPKSFRTDRTEYGFRVSPKFWGQGYAKEGAREMVRYAFEELGLAEVIGETMTINMASRAVMAGCGLTHVETFFNKYDTPPPGIEEGEVRYSITREEWLRMQKPSMTRSRWFPAFASWLPRLLLSRLWSYIFQGRRLAAGAASP
What is the function of this protein?
FsC-acetyl coenzyme A-N(2)-transacetylase; part of the siderophore biosynthetic pathway (PubMed:21622789).  Aspergillus fumigatus produces 4 types of siderophores, low-molecular-mass iron chelators, including excreted fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake and intacellular ferricrocin (FC) for hyphal and hydroxyferricrocin (HFC) for conidial iron distribution and storage.  TAFC consists of 3 N(2)-acetyl-N(5)-anhydromevalonyl-N(5)-hydroxyornithine residues cyclically linked by ester bonds; FC is a cyclic hexapeptide with the structure Gly-Ser-Gly-(N(5)-acetyl-N(5)-hydroxyornithine)x3.  The biosynthesis of all four siderophores depends on the hydroxylation of ornithine, catalyzed by the monooxygenase sidA (PubMed:15504822, PubMed:16113265).  Subsequently, the pathways for biosynthesis of extra- and intracellular siderophores split (PubMed:17845073).  For biosynthesis of extracellular siderophores, the transacylase sidF transfers anhydromevalonyl to N(5)-hydroxyornithine (PubMed:17845073).  The required anhydromevalonyl-CoA moiety is derived from mevalonate by CoA ligation and dehydration catalyzed by sidI and sidH respectively (PubMed:22106303).  The acetylation of N(5)-hydroxyornithine for FC biosynthesis involves the constitutively expressed sidL (PubMed:21622789).  FC is hydroxylated to HFC by an as yet uncharacterized enzyme during conidiation (PubMed:17845073).  Assembly of fusarinine C (FsC) and FC is catalyzed by two different nonribosomal peptide synthetases (NRPS), sidD and sidC respectively (PubMed:17845073).  Subsequently, sidG catalyzes N2-acetylation of FsC for forming TAFC (PubMed:17845073).  Both extra- and intracellular siderophores are crucial for growth during iron limitation and virulence (PubMed:16113265).
What are the official names of this protein?
FsC-acetyl coenzyme A-N(2)-transacetylase, Siderophore biosynthesis protein H.
Protein: RSMG_SYMTH
Sequence: MDATAYRGLLEEGLASLGVEAEPGGVEAVLLHLDLVREWNERMNLTAITDPQEMVIKHALDAASGLAVAGVEPGQRVIDVGTGAGFPGVVWKCLRPGIDLTLLESLQKRCRFLEEVGQAVIGPLAGGEGYQVVWGRAEDVGRNPAHRERYDLVTARAVAELRVLAEYCLPLARVGGRFLAMKGPSVGEEILAAEAAVEKLGGRLEEVRELELPDGGGRRSLVLIRKERPTPKAYPRRAGVPAKSPL
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_SAPOF
Sequence: EKCIVGTGLERQAALDSGVLAIVEHEGKIIYTDTDKIILSGNGDTHSIPLVLYQRFNKNTCMHQNPRIPGGKCIKKGQILADGAATVGGELGLGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTYVTSQGPERVTSEIPHLEAHLLRNLDKNGIVGLGSWVETGDILVGKLTPQMAKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWIQKKGGSNYNPETIHIYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFECSLGLAGGLLDRHYRITPFDERYEHEASRKLVFSELYQASKQTAKPWIFEPEYPGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGHYALVTQQPLR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL11_BURA4
Sequence: MAKKIVGFIKLQIPAGKANPSPPVGPALGQRGLNIMEFCKAFNAQTQGMEPGLPVPVVITAFADKSFTFVMKTPPATVLIKKAAKVDKGSSKPHTDKVGSITRAQAEEIAKTKMPDLTAADLDAAVRTIAGSARSMGITVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ISPE_VIBPA
Sequence: MEHHPMIETSTRWPSPAKLNLFLYINGRTENGYHELQTLFQFVDHGDELTIQANHSGDVTISPEIEGVPLQDNLIWKAATALQNYAHCSFGAHIELHKVLPMGGGIGGGSSNAATTLVALNYLWQLNLTDDELAEIGLKLGADVPVFVRGFSAFAEGVGEKLSPANPEEKWYLVVRPNVSIATADIFRHPDLTRNTPKRDLETLLNAPSVNDCEKIVRMLYPEVDKQLSWLLQYAPSRLTGTGSCVFAEFSSKSEAETILAQLSDKVSAFVAQGRNISPLKETLAEYQSASHRPI
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: SUVR3_ARATH
Sequence: MQRLRESPPPKTRCLGEASDIIPAADRFLRCANLILPWLNPRELAVVAQTCKTLSLISKSLTIHRSLDAARSLENISIPFHNSIDSQRYAYFIYTPFQIPASSPPPPRQWWGAAANECGSESRPCFDSVSESGRFGVSLVDESGCECERCEEGYCKCLAFAGMEEIANECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGWCLYADQLIKQGQFICEYAGELLTTDEARRRQNIYDKLRSTQSFASALLVVREHLPSGQACLRINIDATRIGNVARFINHSCDGGNLSTVLLRSSGALLPRLCFFAAKDIIAEEELSFSYGDVSVAGENRDDKLNCSCGSSCCLGTLPCENT
What is the function of this protein?
Histone methyltransferase.
What are the official names of this protein?
Histone-lysine N-methyltransferase SUVR3, Protein SET DOMAIN GROUP 20, Suppressor of variegation 3-9-related protein 3, Su(var)3-9-related protein 3.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with euchromatic regions.
Protein: UBXN4_MOUSE
Sequence: MLWFQGAIPAAIASAKRSGAVFVVFVAGDDEQSIQMAASWEDEKVTQASSNNFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVQQMHSSKGEASVTNDNQSESSVSTPSASFEPDVCENPESKNTELCETPATSDIKSDTATGGECTGHDSHSQEPHGCSNQRPAEDLTVRVERLTKKLEERREEKRKEEAQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERSREKAEDRAARERIKQQIALDRAERAARFAKTKEAEAAKAAALLTKQAGTEVKRESTARDRSTIARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTREDYKRRLLDLELAPSASVVLLPAGRPATSIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPAQTSARATSTEPSNSASSSKSEKREPVRKRMLEKRGEDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM
What is the function of this protein?
Involved in endoplasmic reticulum-associated protein degradation (ERAD).  Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
What are the official names of this protein?
UBX domain-containing protein 4, Erasin, UBX domain-containing protein 2.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Note=Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.
Protein: MPGP_ECOK1
Sequence: MLSIQQPLLVFSDLDGTLLDSHSYDWQPAAPWLSRLREANVPVILCSSKTSAEMLYLQKTLGLQGLPLIAENGAVIQLAEQWQDIDGFPRIISGISHGEISQVLNTLREKEHFKFTTFDDVDDATIAEWTGLSRSQAALTQLHEASVTLIWRDSDERMAQFTARLNELGLQFMQGARFWHVLDASAGKDQAANWIIATYQQSSGKRPTTLGLGDGPNDAPLLEVMDYAVIVKGLNREGVHLHDEDPTRVWRTQREGPEGWREGLDHFFSAR
What are the official names of this protein?
Mannosyl-3-phosphoglycerate phosphatase, MPGP.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MPGP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPG_CRYNB
Sequence: MGFTLLIDNYDSFTWNIYADLASVGGNPYVVRNDKITLKEIEGMFSDGELERIVISPGPGHPRTDSGVSRDVIAWGMGKLPILGVCMGLECIVDLLGGEIAYAGEIKHGKTSLVQHDSIGVFHNLPQFLSSTRYHSLSAQIQSLPSVLQVTSTTKESGVIMGVRHRTYTVEAVQYHPESCMSEGGRGLMANFIQMKGGKWGGENAWCGVPAEGEEEQPKAKTNGAPSLPTILNRIHAQRLLDVEQAEKVPATSPANVSTSLSLYASPPLINFRDRMVSTPHTAVMAEIKRASPSKGDIAPTASAPEQALKYALAGASVISVLTEPTWFKGSLLDMLAVRNAVDSLPNRPAILRKDFVLSKYMIDEARLYGADTVLLIVAMLEPQQLKELYDYSVSLGMEPLVEVNNPTELSLALEIGSKVIGVNNRNLHDFNVDMSTTSRVNAALNGRDVVLCALSGISSHEDVEKYVKEGVKGVLVGEALMRASDTKAFLRSLIGLPPLEVVPKSRPLVKICGIRSTDDAKLAISAGADLLGVILVPGTKRCISTSTAREISALVQSARSQSSSKPLEPSLSSPWFTTQSDLLSSRRKPLLVGVFQNQSLSDILSAVEEIGLNLVQLHGDEPQAWAKFIPVPVVKVFRVSPEGIVRGGEIRRPGLNQAILLDAGGVSGGGGEGKAFPWEHAKRLIQSGEVGSEGHMPLPVILAGGLTPENVGQAIEQAGEGVWCVDVSSGVEGEGGKVKEKVEAFVKAVRG
What is the function of this protein?
Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
What are the official names of this protein?
Multifunctional tryptophan biosynthesis protein.
Protein: ATPA_ANAPZ
Sequence: MSGVSSGEVLKILRERIENFGGPVKAGSVGEVLSVKDGIAVVYGLHGAGFGETVAFASGVRGVISGLESDIASVVIFGEDREVKEGDSVECTGELMKVPVGFSLLGRVVSPLGMPLDGEGAISGCDGENPVEVKAPGIMARQPVSEPLQTGIKTIDMLIPIGRGQRELIIGDRKTGKTAIALDTIINQKRYNDRAASEKDKVYCIYVAIGQKNSSIARVVSKLCEAGAADYTIVVATGASDSVPLQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKLSDALGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELFHKGFRPAINVGLSVSRVGSAAQVKAVKKVAGSMKLSLAQYRELEDFARFGSDLDASSQAMLEKGRRMIELLKQGQYSPLSVEEQVAVMLAGSDSCIDAIPVGDMCRFERGLLEKLRIDHGDLMACLLEDDVRSKLLEVIRGFAVSF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AT1A1_BOVIN
Sequence: MGKGVGRDKYEPAAVSEHGDKKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAVLCFLAYGIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQDNLPILKRAVAGDASESALLKCIEVCCGSVKEMRERYTKIVEIPFNSTNKYQLSIHKNANAGEPRHLLVMKGAPERILDRCSSILIHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDDVNFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDARACVVHGSDLKDMTPEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPQTDKLVNERLISMAYGQIGMIQALGGFFTYFVIMAENGFLPNHLLGIRVTWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
What is the function of this protein?
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane.  This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection, axon. Melanosome.
Protein: ATPF_STRR6
Sequence: MHVTVGELIGNFILITGSFILLLVLIKKFAWSNITGIFEERAEKIASDIDRAEEARQKAEVLAQKREDELAGSRKEAKTIIENAKETAEQSKANILADAKLEAGHLKEKANQEIAQNKVEALQSVKGEVADLTISLAGKIISQNLDSHAHKALIDQYIDQLGEA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RS16_BACC0
Sequence: MAVKIRLKRMGAKKTPFYRVVVADSRSPRDGRFIEEIGTYNPVAQPAEVKINEEAALKWLGNGAKPSDTVRNLFSNQGIMEKFHLSKQGK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: PETD_VITVI
Sequence: MGVTKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMVSVPAGLLTVPFLENVNKFQNPFRRPVATTVFLIGTAVALWLGIGATLPIDKSLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NAF1_SCHPO
Sequence: MYPHLPCKIPGLSLIYDDESKVEKSKQLSTNASSSNFVKEDQIPSNLSIDNINTPQGDPIDKNNLNTNTENNLPNIVNFQNISSANSGEIKQKDNEILFSSTEDINQHKENYQDENKIDLLDVALANPKDCVVPSSGLLMPKEEFISNEEVGIPATNSSEKSNVKIADEIAEVTHSNSSIGKSSADLSSDSSSDSESNTSFSETDVEEEKAEEKSDAESMAPSTPPKTVNELPEQIYEKPEIVLQPNSLIEPLGKIIQVLKREVVVKSDIDDEKIVFDEKTVLCFEDRSIIGYIHETFGPVSSPYYIVRFSTEEECSAINACMGRPVFYVPTMANKIDPEPLKYIKGSDASNVYDEEINPSEQEFSDDEAEVAAKQLKKKRKRKAKSMVSGNQALPGEANFQSLNQNNVRNYPFYQTNQGSNPPAKRFTQEPPSSSLYSLSESSINYSTQSPMYYNYNYPQPSFPPFHPIYNDSIGYYSQANPQMYYANQVSAPPPQGSFDPNSKFYRNSSDSYRK
What is the function of this protein?
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis.  During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex (By similarity).
What are the official names of this protein?
H/ACA ribonucleoprotein complex non-core subunit NAF1, Nuclear assembly factor 1.
What is the protein family that this protein belongs to?
Belongs to the NAF1 family.
What are the subcellular locations of this protein?
Nucleus. Note=Absent from the nucleolus.
Protein: NPD_RHOBA
Sequence: MNVLILTGAGISAESGIPTFRDANGLWEGHAVEEVATPQGFARNPNLVHEFYNQRRRALLNPEIQPNAAHVALADFEREHLENGRGDFLLVTQNIDNLHQRAGSQNVLAMHGQLLQVRCVYSEEIFDWTGDLSVDTPHPEAPDDDSMRGCLRPNVVWFGEMPIGLTQIEKAATKADLFIAIGTSGVVYPAAGIVAQTPPHCRRIEVNLDDTPASSAFDETIRGAASVEIPKLLNHFSAM
What is the function of this protein?
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins.  Modulates the activities of several proteins which are inactive in their acylated form.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHTA_SALTY
Sequence: MPGSTRKLPVWLPILVLLIAMSSIQSGASLAKSLFPLVGAPGVTALRLALGTLILIAFFKPWRLRFAKEQRLPLLFYGLSLGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRRPVDFIWVVLAVLGLWFLLPLGQDMSHVDLTGAALALGAGACWAVYILTGQRAGAEHGPATVAVGSLIAAIIFVPIGAVQAGDALWHWSILPLGLAVAVLSTALPYSLEMIALTRLPTRTFGTLMSMEPALAAVSGMIFLGETLTGIQILALCAIIAASMGSTLTIRREPQIKQVDVK
What is the function of this protein?
Involved in the efflux of threonine and homoserine.
What are the official names of this protein?
Threonine/homoserine exporter RhtA.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CRUM1_MOUSE
Sequence: MKLKRTAYLLFLYLSSSLLICIKNSFCNKNNTRCLSGPCQNNSTCKHFPQDNNCCLDTANNLDKDCEDLKDPCFSSPCQGIATCVKIPGEGNFLCQCPPGYSGLNCETATNSCGGNLCQHGGTCRKDPEHPVCICPPGYAGRFCETDHNECASSPCHNGAMCQDGINGYSCFCVPGYQGRHCDLEVDECVSDPCKNEAVCLNEIGRYTCVCPQEFSGVNCELEIDECRSQPCLHGATCQDAPGGYSCDCAPGFLGEHCELSVNECESQPCLHGGLCVDGRNSYHCDCTGSGFTGMHCESLIPLCWSKPCHNDATCEDTVDSYICHCRPGYTGALCETDINECSSNPCQFWGECVELSSEGLYGNTAGLPSSFSYVGASGYVCICQPGFTGIHCEEDVDECLLHPCLNGGTCENLPGNYACHCPFDDTSRTFYGGENCSEILLGCTHHQCLNNGKCIPHFQNGQHGFTCQCLSGYAGPLCETVTTLSFGSNGFLWVTSGSHTGIGPECNISLRFHTVQPNALLLIRGNKDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTIAETLTLALVGGSCKEKCTTKSSVPVENHQSICALQDSFLGGLPMGTANNSVSVLNIYNVPSTPSFVGCLQDIRFDLNHITLENVSSGLSSNVKAGCLGKDWCESQPCQNRGRCINLWQGYQCECDRPYTGSNCLKEYVAGRFGQDDSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFFLSDGNVHLISLRIKPNEIELYQSSQNLGFISVPTWTIRRGDVIFIGGLPDREKTEVYGGFFKGCVQDVRLNSQTLEFFPNSTNNAYDDPILVNVTQGCPGDNTCKSNPCHNGGVCHSLWDDFSCSCPTNTAGRACEQVQWCQLSPCPPTAECQLLPQGFECIANAVFSGLSREILFRSNGNITRELTNITFAFRTHDTNVMILHAEKEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLVNDGTWHQVTFSMIDPVAQTSRWQMEVNDQTPFVISEVATGSLNFLKDNTDIYVGDQSVDNPKGLQGCLSTIEIGGIYLSYFENLHGFPGKPQEEQFLKVSTNMVLTGCLPSNACHSSPCLHGGNCEDSYSSYRCACLSGWSGTHCEINIDECFSSPCIHGNCSDGVAAYHCRCEPGYTGVNCEVDVDNCKSHQCANGATCVPEAHGYSCLCFGNFTGRFCRHSRLPSTVCGNEKRNFTCYNGGSCSMFQEDWQCMCWPGFTGEWCEEDINECASDPCINGGLCRDLVNRFLCICDVAFAGERCELDLADDRLLGIFTAVGSGTLALFFILLLAGVASLIASNKRATQGTYSPSGQEKAGPRVEMWIRMPPPALERLI
What is the function of this protein?
May play a role in epidermal tissue morphogenesis (PubMed:14684155).  May function in cell attachment for stratified epithelial organization (PubMed:14684155).
What are the official names of this protein?
Protein crumbs homolog 1.
What is the protein family that this protein belongs to?
Belongs to the Crumbs protein family.
What are the subcellular locations of this protein?
[Isoform 1]: Apical cell membrane; Single-pass type I membrane protein. Secreted. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. SUBCELLULAR LOCATION: [Isoform 3]: Secreted. Cytoplasm. Cell junction, focal adhesion. Note=Found in the cytoplasmic area of undifferentiated keratinocytes and associated with the plasma membrane at the site of cell-cell contacts and focal adhesion upon keratinocytes differentiation.
Protein: TRMA_SHESA
Sequence: MNLAAMDPTTYDAQLTAKRIKLEQAFAQFETPSVEVFASEPAHYRMRAEFRVWHEGDDLYYYMFDKVLNDKVRCDQYLPASALINQMMAALITELKPNHSLRHKLFQVDFLSTLSGEILVSLLYHRQLDDQWRSEAAALKARLSSQFKVNIIGRARKQKIDLDKDFVVESLQVNDKVFHYKQIENSFTQPNAKVAIKMLEWAIDVTQNSQGDLLELYCGNGNFSIALAQNFNRVLATELAKPSVDAAQYNIEVNNIDNLQIIRMSAEEFSDAMAKKRSFRRLEGIDLDSYVCNTIFVDPPRAGIDPATLELVRGYERILYISCNPDTLKDNLQQLNQTHKVTRFALFDQFPYTDHMETGVLLERR
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: SYE_GEOSL
Sequence: MSDVRLRFAPSPTGYLHVGGARTALFNWLLARKQGGTFILRIEDTDVARSTQESVDAILQGMEWLGLDWDEGPFYQSERFPVYREFVERLLAEGKAYRCYCTPEELEARREQAMKEGRKPKYDGTCRDLVTQDADRPFVVRFRAPHEGVTAFDDLIKGRIAFNNEELDDLIIQRTDGTPTYNFVVVIDDATMGITTVIRGDDHINNTPRQILLYEALGYPVPRFAHVPMILGADKTRLSKRHGATSVMAYRDMGFLPEAMVNYLVRLGWSHGDEEIFSRQDLVEKFTIEAVGKSAGVFNPDKLLWLNHHYIKESSPERLAELLVPFLRERGVDPSTGPSLPQVVKTLQERSRTLVEMADGALFYYRSEISYDEEAAAKHLVPGTLPLLASLAEKLDACADFSHSGLEAAFKEFIAEKGIKFGQLGPAVRVSLCGGTASPGIYEVVEALGKDETLRRLRRAVAYLEQ
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT2C_HETCR
Sequence: GSICLEPKVVGPCTAYFRRFYFDSETGKCTPFIYGGCEGNGNNFETLRACRAICRA
What is the function of this protein?
This protease inhibitor shows two different activities, it inhibits both the capsaicin receptor TRPV1 and serine proteases.  It partially (max 50%) and reversibly inhibits mammalian TRPV1, a non-selective cation channel expressed by sensory neurons of the pain pathway (Ref. 2 (By similarity)).  The second activity is a weak inhibition of trypsin and chymotrypsin activity (Ki=0. 9 uM and Ki=4. 5 uM, respectively) (PubMed:20208578).  In vivo, shows analgesic effects on mammals (PubMed:20208578).
What are the official names of this protein?
TauPI-stichotoxin-Hcr2c, TauPI-SHTX-Hcr2c, Analgesic polypeptide HC2, APHC2.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: STMN3_BOVIN
Sequence: MASTISAYKEKMKELSVLSLICSCFYSQPHPNTVYQYGDMEVKQLDKRASGQSFEVILKSPSDLSPESPMLSSPPKRKDTSLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHKALEENNNFSRLAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG
What is the function of this protein?
Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
What are the official names of this protein?
Stathmin-3.
What is the protein family that this protein belongs to?
Belongs to the stathmin family.
What are the subcellular locations of this protein?
Golgi apparatus. Cell projection, growth cone. Cell projection, axon. Cytoplasm, cytosol.