PharMolix/UniProtQA huggingface dataset:
Protein: X_HBVA6
Sequence: MAARLYCQLDSSRDVLCLRPVGAESRGRPLAGPLGALSSPSPSAVPSDHGAHLSLRGLPVCAFSSAGPCALRFTSARCMETTVNAHQILPKVLHKRTLGLPAMSTTDLEAYFKDCVFKDWEELGEEIRLKVFVLGGCRHKLVFAPSSCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: ULAF_ECO81
Sequence: MQKLKQQVFEANMELPRYGLVTFTWGNVSAIDRERGLVVIKPSGVAYETMKADDMVVVDMSGNVVEGEYRPSSDTATHLELYRRYPSLGGIVHTHSTHATAWAQAGLAIPALGTTHADYFFGDIPCTRGLSEEEVQGEYELNTGKVIIETLGDAEPLHTPGIVVYQHGPFAWGKDAHDAVHNAVVMEEVAKMAWIARSINPQLNHIDSFLMNKHFMRKHGPNAYYGQK
What is the function of this protein?
Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 4-epimerase UlaF, L-ascorbate utilization protein F, Phosphoribulose isomerase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. AraD/FucA subfamily.
Protein: YOGA_BACSU
Sequence: MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDLFLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPEILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEHLLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQGKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTSMGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME
What are the official names of this protein?
Uncharacterized zinc-type alcohol dehydrogenase-like protein YogA.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Protein: PGK1_NOTEU
Sequence: MSLSKKLTLDKVDLKGKRVIMRVDFNVPMKNKEITNNQRIKAALPSINYCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAAELKSLLGKDVLFLKDCVGPEVEQACANPPNGSIILLENLRFHVEEEGKGKDASGNKIKAEPAKMEAFQASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKACGFLMKKELTYFAKALDSPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMGFTFLKVLNNMEIGTSLFDEEGAKIVKDLMAKAEKNGVKITLPVDFVTADKFDENAKTGQATLASGIPAGWMGLDCGPKSSKKYVEVVTWAKQIVWNGPVGVFEWEEFARGTKELMNNVVEATKRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVSTLNNV
What is the function of this protein?
Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate.  In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).  May play a role in sperm motility.
What are the official names of this protein?
Phosphoglycerate kinase 1.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1887_STRPF
Sequence: MTHNHENDHQHEVITLVDEQGNETLFEILLTIDGREEFGKNYVLLVPAGSEEDESGEIEIQAYSFTENEDGTEGDLQPIPEDSDAEWDMIEEVFNSFLDEN
What are the official names of this protein?
UPF0473 protein MGAS10750_Spy1887.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: OTU6_ARATH
Sequence: MTRILVQRGSSGSSSNSSRPSSSSSSSSGSETQINNNIPVPPVTIDEEITDEKQEEVTVVEKAECSDAKDVAVDSDEPADREDDEGLVVAENVHVQSEGIDCDSPVSGGSNSDSPPVPAPPPKPSSTVNPGSNRSVLGSFGALRIGPTRRAAGPRSLVSSRSSPTGSHPSSPRSHSENEGYNSSDEHMPCYVPSHPGSGLEREHQFEAEIRYSKGFEIRRMLEDGNCLFRAVADQVYGDSEAYDLARQMCMDYMEQERDHFSQFITEGFTSYLKRKRRDKVYGNNVEIQALAEMYNRPIHIYSYSTEPINIFQGNYSTDTPPIRLSYHHGNHYNSLVDPHRLTVGAGLGFSSLSGRHVDKEQVKAAIKAQQEHQIDNALLAEGRFYSDLELTEKEIERSVMEASRAEYLMEWSKPRIGPKESSTSNAETSSSGARPSGSDSKPAEAVKEKTVLSSSIEMVLSMGFSYAQAMEAYSIFGDDVDSMVCYVLETSCGGNNRRKGKATE
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (PubMed:21690391, PubMed:24659992).  Binds chromatin (e. g.  nucleosomes and histones) and has enzymatic histone deubiquitinase activity, specific for the H2B histone (PubMed:21690391, PubMed:28703681).  Can both repress (e. g.  OSR2) and promote (e. g.  AN3) the expression of target genes by associating with chromatin, deubiquitinating H2B and regulating its euchromatic histone marks (e. g.  H3ac and H3K4me) (PubMed:28703681).  In association with LDL1/KDM1C, involved in transcriptional gene repression via histone deubiquitination and demethylation (PubMed:21690391).  Promotes the concerted epigenetic regulation and repression (e. g.  the removal of euchromatic histone acetylation, ubiquitination, and methylation marks) of a set of genes (e. g.  GA20OX, WUS, OSR2, ARL and ABI5) that collectively limit plant growth thus stimulating plant growth and increasing cell size (PubMed:27999174).
What are the official names of this protein?
OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 6, OTU domain-containing protein 6, Deubiquitinating enzyme OTU6, Otubain-like deubiquitinase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C85 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: F17FG_ECOLX
Sequence: MTNFYKVFLAVFILVCCNISHAAVSFIGSTENDVGPSQGSYSSTHAMDNLPFVYNTGHNIGYQNANVWRISGGFCVGLDGKVDLPVVGSLDGQSIYGLTEEVGLLIWMGDTNYSRGTAMSGNSWENVFSGWCVGNYVSTQGLSVHVRPVILKRNSSAQYSVQKTSIGSIRMRPYNGSSAGSVQTTVNFSLNPFTLNDTVTSCRLLTPSAVNVSLAAISAGQLPSSGDEVVAGTTSLKLQCDAGVTVWATLTDATTPSNRSDILTLTGASTATGVGLRIYKNTDSTPLKFGPDSPVKGNENQWQLSTGTETSPSVRLYVKYVNTGEGINPGTVNGISTFTFSYQ
What is the function of this protein?
Essential fimbrial adhesion factor that mediates binding to N-acetylglucosamine-containing receptors in the host intestinal microvilli, leading to colonization of the intestinal tissue, and diarrhea or septicemia.  Also confers adhesiveness to laminin and basement membranes (By similarity).
What are the official names of this protein?
F17f-G fimbrial adhesin.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium. Note=Attached to the tip of the fimbrial filaments.
Protein: PHXR1_MOUSE
Sequence: MPIVCFDPPYELYLHWPLAGEVQSQYWGTGDRGISGAHWPAPGSLREAVSEKKKIIKKDT
What are the official names of this protein?
Putative per-hexamer repeat protein 1.
Protein: ANFD_RHOCA
Sequence: MPYHEFEVSKCIPERREHAVMKAAGEDLTSCLPKGYLNTIPGTISERGCAYCGAKHVIGTPMKDVIHISHGPNGCTYDTWQTKRYISDNDNFQLKYTFATDVKEKHVVFGAEGLLKKSMHEAFDAFPNIKRMTVYQTCTTALIGDDVDAIAKEVMEERGDVDVFVCNSPGFAGPSQSGGHHKINIAWLNQKVGTVEPDYLGEHVINYVGEYNIQGDQEVMIDYFNRMGIQVLSTFTGNGSYDSLRMMHRAHLNVLECARSAEYICDELRARYGIPRLDIDGFGFEPLANSLRKVALFFGIEDKAEAIIAEEYAKWKPQLDWYKERLKGKKVCLWPGGSKLWHWAHAIEEEMGLKVVSVYTKFGHQGDMEKGVSRCGEGALAIDDPNELESVEAIEMLKPDIIFTGKRPGEFVKKHGVPYLNAHAYHNGPYKGFEGWVRFARDIYNAIYSPMRQLAALDISAPDAAITSGFRTAKMNADLTVSDEVKFSEVLHEYTGKYDSIAEIRARNQPMPPSRKLRDAVQPAAE
What is the function of this protein?
This iron-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.  Other nitrogenase complexes utilize a molybdenum-iron protein or a vanadium-iron protein.
What are the official names of this protein?
Nitrogenase iron-iron protein alpha chain, Dinitrogenase 3 subunit alpha, Nitrogenase component I.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: DXR_EHRRW
Sequence: MKTVSIFGSTGAIGQMIIDVILASSDSYQVKALVAKSNVQLLAFQAKIVNAEMVVIADVGLYKELKDLLFGTNVKISVGDVGMQMAASLNVDYVMMAIVGIAALVPMVYLISAGVKVIALANKESVVCGGTLLFNLAREKNVNVIPVDSEHNAIFQILHSNDRENIDKITITGSGGALLYMDYDQMRNITVQETIKHPVWKMGKKISVDSATMVNKSLEIIEAYHLFSVKPEKLDVIIHPEAIVHGIVSYVDGACIAFMSVPDMKISIMYTLSWPNRMSMLYKKLNLASYHQLTFMKPDINKFPGIRLGFEILRTSNIHANSIIFNTANEIAVDAFLNRKIGFLDIVNVIYSTLDMVDCLHINSLSDILECDSIARRVASDIICKLN
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: RS9_ECO8A
Sequence: MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRSELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: BASI_CRIGR
Sequence: AAGTIQTSVNDVGSKTHLTCSLNSSGVDIIGHRWMRGGKILQEDTLPDLQTQYTVDIDDRSGDYACIFLPEPVGRSNIVVEGPPRIKVGKKSEHSSEGENVRLICKSESSHPPVTEWSWFKTSDSGDQLITNSSESKYVVISTADRSELTISNLDINSDPGTYMCNATNTQGSVQEIMTLRVRSRLAALWPFLGIVAEVLVLVTIIFIYEKRRKPDQTLDEDDPGAAPLKGSGHHMNDKDKNVRQRNAT
What is the function of this protein?
Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity).  Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (By similarity).  Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity).  Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity).
What are the official names of this protein?
Basigin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single- pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein.
Protein: Y149_UREPA
Sequence: MEKIVGFIVNIINVQKQMIKDLKELKNHKDIMVKDHEKLNDMLNSMIDEAVKNYKIALKNITEILNVHLNCVLYNHNLKCGVKDEKLLLPLFKRKKAS
What are the official names of this protein?
Uncharacterized protein UU149.
Protein: DCUP_CUPPJ
Sequence: MTALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVTLQPLDRYPLDAAILFSDILTVPDAMGLGLSFAQGEGPRFARPLRTEADVQKLAVPDMASLQYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKAMMYGRPDLMHRILDINAQAVSEYLNAQIEAGAQAVMIFDTWGGALADGMYQAFSLAYMRKVLAGLKREHDGQQIPAIVFTKGGGLWLEGLADTGADAIGLDWTVNLAQARRRTGGRVALQGNIDPTVLFAPEAAIREQVRGVLDSYAAAGGSDGHVFNLGHGISQFTPPESVAVLVDEVHRYSRQLRTSQG
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD1_CHICK
Sequence: MSTEKLKHHKIIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMLAKADTSKGFLIDGYPREVKQGEEFEKKIAPPTLLLYVDAGKETMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYKGRGIVRQLNAEGTVDEVFQQVCSYLDKL
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:2161682, PubMed:2229026, PubMed:2542324, PubMed:1958702).  Exhibits nucleoside diphosphate kinase catalyzing the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and dTTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor (By similarity).  Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (PubMed:2229026, PubMed:8431472).
What are the official names of this protein?
Adenylate kinase isoenzyme 1, AK 1, ATP-AMP transphosphorylase 1, ATP:AMP phosphotransferase, Adenylate monophosphate kinase, Myokinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_GLOVI
Sequence: MTRARMYYDEDADLSVLDNKTIAIVGYGSQGHAHALNLKDSGIDVIVGLYEGSRSWARAENEGLAVYPTAEAAAKADLVMILLPDEVQREIYNRDIAPHLGTGKTLAFAHGFNIHFSQIVPSQEVDVLMVAPKGPGHLVRRVFTEGKGVPCLFAVEQDASGRARATAMAYARAIGGTRAGILETTFREEAETDLFGEQTVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLIVEGGLAKMRDSISNTAEFGDYTRGPRIVDERTKAEMKKILAEIQNGEFAKQWVLDSQANYASFKAMRRREAEHPIEEVGADLRKMMSWLRP
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: IXTPA_DESRM
Sequence: MKLVLATNNKGKVKELAELLKPCGYQVVSIGEFPGFTEVEEDGNTFADNAIKKALAAAEFTGELALADDSGLEVDALKGAPGVYSARFAGEPKDDTANNAKLLSLLEGVPQDHRTARFRCVIAIAEPNGRIHTAEGSCEGVILRELKGEGGFGYDPLFYVPEYKQTFAELDMEKKNSISHRGKALKKAMEILNRLYIHQEV
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: SDH4_ARATH
Sequence: MSLRRTILDLHRQTQRATLSKSLPFSMSHISSASATAAVRNPLGRDLSSIPFAQAQKLKPDSTNLVTDRSISSSIGQSELNKAAKFSRQSSSRGYTNGSFLRKIPVVFHIHEGMEEILADYVHQEMTRNLIVMSLGLFQIIVLKDIILFLL
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase subunit 4, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PPP6_DICDI
Sequence: MSNALPLDEWVETARQCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQITQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPEDIEQWQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAVQEERNIPTRPTMQYFF
What are the official names of this protein?
Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
Protein: PKS11_MYCTU
Sequence: MSVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKPTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEKRPPSGSAGLMLAMGPGFCTELVLLRWR
What is the function of this protein?
Involved in the biosynthesis of methyl-branched alkylpyrones (PubMed:23615910).  Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA and methylmalonyl-CoA as extender molecules to synthesize polyketide products (PubMed:12941968, PubMed:23615910).  Palmitoyl-CoA or a similar long chain fatty acid derivative is the likely substrate in vivo (PubMed:23615910).
What are the official names of this protein?
Methyl-branched alkylpyrone synthesis polyketide synthase-like Pks11, Chalcone synthase-like protein, CHS-like, Methyl-branched alkylpyrone synthesis polyketide synthase type III Pks11.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: DIK1A_PONAB
Sequence: MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGKCLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAKLGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKLMGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQSTMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS
What are the official names of this protein?
Divergent protein kinase domain 1A, Protein FAM69A.
What is the protein family that this protein belongs to?
Belongs to the DIPK family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: SECA_CAUVN
Sequence: MLGFAKKLFGSSNERKVKTLATRVAKINAYEAEYAALSDEALKGKTAEFKARLEKGETLDDILNEAFAVVREASKRVLGMRHFDVQMVGGMVLHFSGISEMRTGEGKTLVATLPTYLNALEGKGVHVITVNDYLARRDADWMGQVYNFLGLSYGVIVNGLSQGERQRAYRSDITYGTNNEFGFDYLRDNLVYSVDEMVQRGHNFAIVDEVDSILIDEARTPLIISGPTEDRSSFYKTIDVLVKELILDKSMFDHDEKQKQVILTEDGQEKIEEILMSGGHLAEDSAGLYDAANVSVVHHVNQALRANILYTRDKDYIVKGGEVVLIDEFTGRMMTGRRLSEGLHQAIEAKEGADIQPENQTLASVTIQNYFRLYKKLSGMTGTASTEAQEFDDIYKMSVSEIPTNRTIQRIDDDDEVYRTEREKNEAILKQIADCHVRGQPILVGTVSIEKSEELSKLLSTFSFEKDGKKVKGIPHQVLNARFHEQEAVIVADAGVPGAVTIATNMAGRGTDIQLGGSIDMRLFNWRQQQRGMGLEITVEDEAEERARLETEIADKKAQALAAGGLFVLGTERHESRRIDNQLRGRTGRQGDPGRSKFFLSCEDDLLRIFAGERLDAIMRTFGVQEGEAITHKWLNNAIATAQKRVEQRNYEIRKNLLKYDDVVNDQRKAVFEQRQEFMESSDLSDIIHEMRRDVIDDLVLRHLPPKAYAEQWDVEGLTERVKSILGLDLPIAEWAAEEGIADEEMKERITKAADEYAAQREVIITPEQMRSVEKSFLLQMIDLQWREHLMHLDHLRNVIGLRGYGQRDPLNEYKTEAFSLFEKLLGDLRTNTTRWLMTVEIAYAEPEVPHTPLDNLVEVHLDPLTGENAAFAGGIPEGLSTAQREALPVSALPEGWDRTNRNAPCPCGSGKKFKQCHGSLVR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: EST3_CANAL
Sequence: MFRSVSLSSLIPFLIIVSIAMQRPENDVPMIMQSSWLVNEVIKSINSNGQYINALIKKDFQPTVLPVSFILRILKFTATTDSKDITAVLADSTHKIFAIFLFFPAIVDFENKYHHRMTYNTRSCLIRIHKANLKFMDKSTVKKCYGRKSDGGLAIAVLEVLEFDIFFKDQYSFINSIENRLKYVYDDVEYNQLCGKKKHKPEYEDLMCDI
What is the function of this protein?
Component of the telomerase complex involved in telomere replication.  Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).
What are the official names of this protein?
Telomere replication protein EST3.
What is the protein family that this protein belongs to?
Belongs to the EST3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RL34_DESOH
Sequence: MKRTYQPSNVKRARKHGFRARMATKQGRSILKRRRAKGRKRLTV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: MIAB_BURCH
Sequence: MTKKVYVKTFGCQMNEYDSDKMVDVLNAAEGLEKTDTPEDADIILFNTCSVREKAQEKVFSDLGRVRELKEAKPGLLIGVGGCVASQEGASIVSRAPYVDLVFGPQTLHRLPQMIDARRASGRAQVDITFPEIEKFDHLPPARVEGPSAFVSIMEGCSKYCSYCVVPYTRGDEVSRPLDDVLTEVAGLADQGVREVTLLGQNVNAYRGALTAGSTDIADFATLIEYVADIPGIERIRYTTSHPKEFTQRLIDTYAKVPKLVSHLHLPVQHGSDRILMAMKRGYTVLEYKSVIRKLRAIRPDLSLSTDMIVGFPGETEDDFDKMMALVHEMGYDTSFSFIYSPRPGTPAANLADDTPREVKLKRLQHLQATIEENVARISQSMVGKVERILVEGPSRKDPNELAGRTENNRVVNFPAPLASHPRLIGQMIDVKINHAYPHSLRGELVLVSDDASTATH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA24F_HUMAN
Sequence: MLWALWPRWLADKMLPLLGAVLLQKREKRGPLWRHWRRETYPYYDLQVKVLRATNIRGTDLLSKADCYVQLWLPTASPSPAQTRIVANCSDPEWNETFHYQIHGAVKNVLELTLYDKDILGSDQLSLLLFDLRSLKCGQPHKHTFPLNHQDSQELQVEFVLEKSQVPASEVITNGVLVAHPCLRIQGTLRGDGTAPREEYGSRQLQLAVPGAYEKPQLLPLQPPTEPGLPPTFTFHVNPVLSSRLHVELMELLAAVQSGPSAELEAQTSKLGEGGILLSSLPLGQEEQCSVALGEGQEVALSMKVEMSSGDLDLRLGFDLSDGEQEFLDRRKQVVSKALQQVLGLSEALDSGQVPVVAVLGSGGGTRAMSSLYGSLAGLQELGLLDTVTYLSGVSGSTWCISTLYRDPAWSQVALQGPIERAQVHVCSSKMGALSTERLQYYTQELGVRERSGHSVSLIDLWGLLVEYLLYQEENPAKLSDQQEAVRQGQNPYPIYTSVNVRTNLSGEDFAEWCEFTPYEVGFPKYGAYVPTELFGSELFMGRLLQLQPEPRICYLQGMWGSAFATSLDEIFLKTAGSGLSFLEWYRGSVNITDDCQKPQLHNPSRLRTRLLTPQGPFSQAVLDIFTSRFTSAQSFNFTRGLCLHKDYVAGREFVAWKDTHPDAFPNQLTPMRDCLYLVDGGFAINSPFPLALLPQRAVDLILSFDYSLEAPFEVLKMTEKYCLDRGIPFPSIEVGPEDMEEARECYLFAKAEDPRSPIVLHFPLVNRTFRTHLAPGVERQTAEEKAFGDFVINRPDTPYGMMNFTYEPQDFYRLVALSRYNVLNNVETLKCALQLALDRHQARERAGA
What is the function of this protein?
Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256).  Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256).  Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256).  In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256).
What are the official names of this protein?
Cytosolic phospholipase A2 zeta, cPLA2-zeta, Phospholipase A2 group IVF.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Mitochondrion.