PharMolix/UniProtQA huggingface dataset:
Protein: HEM3_BRUA1
Sequence: MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKGLFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAGPHFFDGWQ
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: SGTA_BOVIN
Sequence: MDNKKRLAYAIIRFLHDQLRHGELSSDAQESLEVAIQCLETAFGVTVEDSDLALPQTLPEIFEAAAAGKELPPDLRSPQETPPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPSYSKAYGRMGLALSSLNKHTEAVAYYRKALELDPDNETYKSNLKVAELRLREAPSPTGGVGSFDIAGLLNNPSFMSMASNLMNNPQVQQLMSGMISGGHNPLGTPGTSPSQNDLASLIQAGQQFAQQMQQQNPELIEQLRSQIRSRTPSASNDDQQE
What is the function of this protein?
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol.  Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails.  Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module.  Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins.  It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states.  Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex.  Binds directly to HSC70 and HSP70 and regulates their ATPase activity.
What are the official names of this protein?
Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT.
What is the protein family that this protein belongs to?
Belongs to the SGT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis. Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126.
Protein: KANU_BACSP
Sequence: MNGPIIMTREERMKIVHEIKERILDKYGDDVKAIGVYGSLGRQTDGPYSDIEMMCVMSTEEAEFSHEWTTGEWKVEVNFDSEEILLDYASQVESDWPLTHGQFFSILPIYDSGGYLEKVYQTAKSVEAQKFHDAICALIVEELFEYAGKWRNIRVQGPTTFLPSLTVQVAMAGAMLIGLHHRICYTTSASVLTEAVKQSDLPSGYDHLCQFVMSGQLSDSEKLLESLENFWNGIQEWTERHGYIVDVSKRIPF
What is the function of this protein?
Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.
What are the official names of this protein?
Kanamycin nucleotidyltransferase.
Protein: YEJM_SALTY
Sequence: MVTHRQRYREKVSQMVSWGHWFALFNILLATLLGSRYLFVADWPTTLAGRIYSYLSIVGHFSFLVFATYLLILFPLTFIVMSQRLMRFLSAILATAGMTLLLIDSEVFTRFHLHLNPIVWELVINPDQNEMARDWQLMFISVPVILLIEMLFATWSWQKLRSLTRRRHFARPLAAFFFVSFIASHLIYIWADANFYRPITMQRANLPLSYPMTARRFLEKHGLLDAQEYQRRLVEQGNPEAVSVQYPLSNLHYRDMGTGQNVLLITVDGLNYSRFEKQMPELATFAEQNIDFTRHMSSGNTTDNGIFGLFYGISPGYMDGVLSTRTPAALITALNQQGYQLGLFSSDGFASPLYRQALLSDFSMPAAQTQSDAQTASQWIDWLGRYAQEDNRWFSWISFNGTNIDDSNQKNFVKRYASAASDVDAQINRVLNALREAGKFDNTVVIITAGRGIPLTPEENRFDWSQGHLQVPLVIHWPGTPAQRINVLTDHTDVMTTLMQRLLHVSTPANEYSQGQDIFTVPRRHNWVTAADGSTLAITTPQMTLVLNNNGHYQTYDLHGEKIKDQKPQLSLLLQVLTEEKRFIAN
What are the official names of this protein?
Inner membrane protein YejM.
What is the protein family that this protein belongs to?
To H.influenzae HI_0842.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FLGI_CAUVC
Sequence: MPRSLFRTVLTALVAASCLIAAPALAKSRIKDIVSFEGVRENQLIGYGIVVGLNGTGDSLRNAPMTKQSLEAMLERQGVNVRDNNLNTKNTAAVMVTANLPPFSASGSKVDVTVSTLGDAKSLLGGTLLVTSLQGADGQTYAVAQGTVQTGSVSAGGASGSSVTKGVPTAGRIAGGGVIERETGFQMVNMDIMRLTLRNPDFTTARRVADAINAKFPGCAQAQNPTIIATRPPPGMDMISFMTNIENLMVEPDGPAKVVIDEVAGVIVMGDDVRISQVAIAQGNLTITVQENPAVSQPAPFSQGQTAVVPQSTVNVEEEKGKQLLTLGGAPSLKGLIGGLNALGVTPRDMISILQAVKAAGALQADIEVM
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: BRLA_EMENI
Sequence: MRNQSSLSDRLTVEVDCSSLGSNECPSMTSSFSPLESPTPTPTSIYSQGSLESPGWHGAGSLPNNTYERTPGSASMRSAFRLAGMASTESLGLPYGSMEGQERMPMPDFLSGYDENIEQLWMPSEAPKSYDHVAQGLAYHQGMHQYPTMARNTNNNYRHQAAAYLPESTTNPCLSRSIFHQPERVPSSMSSSMSMNNMLPWMNLGDSIAPQTIAPSQVGPVTPPPSYTDFPTSLSAFKQHSPTTPIRSCSLGTGSGADTPLSRLSGGPCEYMDDFQPSPVYRDGFQRPHRVASRKMLRRQTSKQNLMLENLPQVIKQVQFKCKEPGCNGRFKRQEHLKRHMKSHSKEKPHVCWVPGCHRAFSRSDNLNAHYTKTHSKRGGRNRYVATLDENSPDYDPEFRGQLTPDGRPIYGSKLDDPIPGAGDMSLDGWDE
What is the function of this protein?
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (PubMed:8508769, PubMed:5366214, PubMed:2823119, PubMed:2655931, PubMed:2196567, PubMed:7704830).  They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (PubMed:2823119, PubMed:2655931, PubMed:2108321).  Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (PubMed:8417986).  Controls the expression of the conidiophore-specific phenol oxidase ivoB (PubMed:1901560).  Controls the expression of the hydrophobin rodA (PubMed:2065971).  Mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores (PubMed:3293800).  Expression of brlA leads to activation of abaA, wetA and stuA, cessation of vegetative growth, cellular vacuolization and spore formation.
What are the official names of this protein?
C2H2 type master regulator of conidiophore development brlA, Bristle A protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: K22E_HUMAN
Sequence: MSCQISCKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSFSCLSRHGGGGGGFGGGGFGSRSLVGLGGTKSISISVAGGGGGFGAAGGFGGRGGGFGGGSSFGGGSGFSGGGFGGGGFGGGRFGGFGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSVTFSFR
What is the function of this protein?
Probably contributes to terminal cornification (PubMed:1380918).  Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329).  Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins (By similarity).  Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).
What are the official names of this protein?
Keratin, type II cytoskeletal 2 epidermal, Cytokeratin-2e, CK-2e, Epithelial keratin-2e, Keratin-2 epidermis, Keratin-2e, K2e, Type-II keratin Kb2.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIG1_BOVIN
Sequence: MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHIPQEHEGDLDPQTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNDILYDGENHDCEEKPQDIVQSIVEEMVNIVVGDTGERTTINVSADGNNGTIEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFGTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQETSEMKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFTKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPAKSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSLTGAKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGYTYEKHWWQDLFRIVFRIFDNMKLPEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPISGETAPPTPSPVSENQLDTISQKSVDIHDSIQPRSADNRQQAPLASVSTVNEEISKIKPTAKFPEQKLFAALLIKCVVQLELIQTIDNIVFFPATSRKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYTDESRASAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRFKAHASFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPEQELGINKQ
What is the function of this protein?
Promotes guanine-nucleotide exchange on ARF1 and ARF3.  Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP.  Involved in vesicular trafficking.  Required for the maintenance of Golgi structure; the function may be independent of its GEF activity.  Required for the maturaion of integrin beta-1 in the Golgi.  Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing.  Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.  Inhibits GAP activity of MYO9B probably through competitive RhoA binding.  The function in the nucleus remains to be determined (By similarity).
What are the official names of this protein?
Brefeldin A-inhibited guanine nucleotide-exchange protein 1, Brefeldin A-inhibited GEP 1, ADP-ribosylation factor guanine nucleotide-exchange factor 1, p200 ARF guanine nucleotide exchange factor, p200 ARF-GEP1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Nucleus. Nucleus, nucleolus. Nucleus matrix. Membrane. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.
Protein: SODM_VIRHA
Sequence: AKFELPELPYAYDALEPTIDKETMNIHHTKHHNTYVTKLNGALEGHEDLKNKSLNDLISNLDAVPENIRTAVRNNGGGHANHSLFWKLMSPNGGGKPTGEVADKINDKYGSFEKFQEEFAAAAAGRFGSGWAWLVVNNGEIEIMSTPIQDNPLMEGKKPILGLDVWEHAYYLKYQNKRPDYISAFWNVVNWDEVAAQYSQAA
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.  Active only in homodimeric state.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1982_AQUAE
Sequence: MVKVSAENFLYFAISVLVNLLFLKILYIYLFLPNISPPQAFTPLSVKIEEIKAPPKKPGKPQKKVVKKKPEAVSVSQAPEKGDVPVEVKEEKEVSLLPELEKKIKERLKKRKEVKQIGEISAVVSKQKVEIRLGSRKLVHVPPPPVFHVKEYPSLVRIKIWVNPEGRVIRAIIIQRSGVTEVDEGLLRFTKKLKFEPIEVPEVQEGVITFTFST
What are the official names of this protein?
Uncharacterized protein aq_1982.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PYRE_CLOP1
Sequence: MKNTDAMVIDTLKEVGALLEGHFLLSSGRHSNRYCQCAQLLKYPEKAEKVLKVVADQLKDIDFDLVVGPAMGGVIVAYELGRQLGKPAIFTERENGEMTLRRGFTIEKGQKVVITEDVVTTGKSFKEAAKVIEEQGGEVVAVVCIVDRTPGNVTDFPMYSSIKLDIESFEAENCPLCKEGVPYIKPGSRNIK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: ARPC3_ARATH
Sequence: MVYHSSFVDEEGVTKACGCPLLPLKSHIKGPAPVSEQDKTDIVDEAITFFRANVFFTNFDIKSPADKLLIYLTFYINVALKRLEGCRTLAVGTKAIINLGLEDIPVPGETGFPFPGLFSLPQSQDEAELFRNYLKQVREETSGRLLSVAYRANGTPNKWWLAFAKRKFMNVVVL
What is the function of this protein?
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 3, Actin-related protein C3, Arp2/3 complex 21 kDa subunit, p21-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection.
Protein: SUFE_YERPY
Sequence: MAGLPDRDKLIRNFSRCLNWEEKYLYIIELGGQLAPLTEQQRHPENLISGCQSQVWIAMTLSAEGHVIFAGDSDAAIVKGLVAVVFILYHDLTPQQIISLDVRPFFADLALSQHLTPSRSQGLEAMIRAIRTKVANLSAH
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_BARBK
Sequence: MLAKFESMMSNKVQTDDDFTQTQNPFTLFASWLEEATISEINDPNAMALATVDETGLPNVRIVLLKNFNSTGFVFYTNYESCKGQEILKSMKASLVFHWKSLRRQIRIRGLVEQVSPEEADAYFQSRPYGSQIGAWASKQSQLLEDRFVLEKEVSRYTADYAIGNVPRPPYWSGFRIKPLFIEFWRDRPSRLHDRLLFTRDFLEQNNWKKQRLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: KCRS_HUMAN
Sequence: MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCAEVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK
What is the function of this protein?
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e. g.  creatine phosphate).  Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
What are the official names of this protein?
Creatine kinase S-type, mitochondrial, Basic-type mitochondrial creatine kinase, Mib-CK, Sarcomeric mitochondrial creatine kinase, S-MtCK.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: SYC_XANAC
Sequence: MPMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRRYGALRYARNITDVDDKINAAAQAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAHIPQIVAMIEQLIANGHAYAAEGHVLFSVSSFDGYGKLSRRDPDEMLAGARVDVAPYKRDPGDFVLWKPSSADLPGWESPWGRGRPGWHIECSAMAAAHLGPTIDIHAGGVDLQFPHHENEIAQSECAHGGATFARFWLHNGMLNFSGAKMSKSLGNIETVHELIARHPPEALRYALLSAHYRQPLDWSDGLIEQAKNTLDRLYGTLRDLAALQADSGNDVAPSRTIPVEVESALEDDLNTPLALSVIASIASEARALRNELVHGGEPSTRMSDLHAVHAKLLGAGLALGLLQQDPAAWFSRGTDAGDDARITALVEERSTAKKAKDFARADAIRKQLAEEGIVLEDTPQGVRWKRA
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I01A0
Sequence: MSLLTEVETPTRNEWECKCSDSSDPLVVAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: YIDC_BURCH
Sequence: MDIKRTVLWVIFFMSAVMLYDNWQRDHGRPSMFFPSATHTAPAAAGGASGTSATTAGDVPAAAAGAAPSTTAPAAQAQLVKFSTDVYDGEIDTRGGTLAKLTLKKQGDGKQPDLYITLFDHTAGHTYLARTGLLGGDFPNHNDVYTQLNPGSTSLTGDENTLKLSFESPVKGGVKVVKTYTFTRGSYVIGVDTKIDNVGTAPVTPTVYMELVRDNTAVETPMFSHTFLGPAVYTDAKHFQKIDFSDLDKNKANFEKSSDNGWVAMVQHYFASAWIPQQGAKRDIYAEKIDPTLYRVGVKQPVAAIAPGQSADVQARLFAGPEEERMLEGIAPGLELVKDYGWVTIIAKPLFWLLEKIHGYVGNWGWAIVLLTVLIKAVFFPLSAASYKSMARMKEITPRMQALRERFKSDPQKMNAALMELYKTEKVNPFGGCLPVVIQIPVFISLYWVLLASVEMRGAPWILWIHDLSQRDPFFILPVLMAVSMFVQTSLNPTPPDPVQAKMMKFMPIAFSVMFFFFPAGLVLYYVVNNVLSIAQQYYITRKLGGVKKKPA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASPG4_SCHPO
Sequence: MWGFIVTCGIFLVLLCQLRLLSKRKSKSTPYNALLPNVTVFAMGGTIAGCANSSLEIVNYIPGSVGIEKLIEAVPAIKAIANINGVQVTNMGSENLTPADVLKLAKLILAEVAKPNVHGIVITHGTDSLEETAMFLDLTISTAKPIVVVGAMRPSTAIGADGPMNLLNAVAVASSNQSMGRGTLVLLNDRIGSAFYTTKTNGNTLDTFKSYEAGSLGIVLNQKPFYFFSPAVPTGKVFFDIYNIKQLPRVDILYGYQGLNPKLAESAVHLGAKGLVLAAMGATSWTDDGNEVISSLIREHNIPVVYSHRTAEGYSSNSCLGIPSYFLNPQKARYMLMLAISSGYSIRDIEGLFSIK
What are the official names of this protein?
Probable L-asparaginase 4, L-asparagine amidohydrolase 4.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RPOZ_BACVZ
Sequence: MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQQIEHTISHKYVGKALEEIDAGLLSFEREDSE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RNH3_LISMO
Sequence: MANTVILVDQPTLEKMKQTYLPFSNPKLPPGAVFAAKKPGVSITGYKSRKVMFQGVNGEAEAKKWVATLPESKAKAPSVSKGILPANFASKNVIGSDEVGTGDFFGPITVCAAYVDAEMMPLLKELGVKDSKAMKDPEICRIAEKIMPLVPHSVLLCPNPKYNELQKRGMNQGQMKALLHNRAIENVLKKLAPIKPEAILIDQFAEKNTYYRYLAKEPSIIREDVFFATKAEGLHLSVAAASIIARYKFVQAFDAMSKEVGIPLPKGAGPHVDAVAAEIIERFGLETLAKYTKQHFANTEKALKMVKK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLF2B_MOUSE
Sequence: MAAPAPRARTGGKKKDERRGFKGYKWEFRDSNKDFWAQGHAECKSLIMILLIAAMVCFQRVATHPIVILLLTMELSICAFFFFLYSLAINRYIPFVFWPMMDLMNDLACSTFLIGGIFFALEARRELPVPYLTGMILMGVTAFISIIDLCLQRRQFKSRKLRKFILLTPDRKGKKQDPKLLLMLAAKEDEEERQRELAEKAKRESMDPGW
What are the official names of this protein?
CKLF-like MARVEL transmembrane domain-containing protein 2B, Chemokine-like factor superfamily member 2B.
What is the protein family that this protein belongs to?
Belongs to the chemokine-like factor family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y5042_ACAM1
Sequence: MLNLTLTFLVVALIAAFLGFSGIAASAAAIAKILFCIFIVCFILVWPNKTGLVPVQEYPGRSCLHL
What are the official names of this protein?
UPF0391 membrane protein AM1_5042.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL20_MYCS5
Sequence: MARVKGGTVTRARRKKWIKLAKGYFGHKSVGYKVAKQAVVKSWTYAFRDRKQVKRNFRKLWIARINAAVRPHGLSYSQFINGLKKAEVLINRKMLSELAINQPQTFEKLVKLVQGK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: IBB2_SETIT
Sequence: SGERPWKCCDLQTCTKSIPAFCRCRDLLEQCSDACKECGKVRDSDPPRYICQDVYRGIPAPMCHEHQ
What are the official names of this protein?
Bowman-Birk type major trypsin inhibitor, FMTI-II.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.