PharMolix/UniProtQA huggingface dataset:
Protein: XPOT_ASPFU
Sequence: MEEQVANAIEIASNPSADPALKTQAFDFVNQLRSDPSGWQVCLSLFTQTPQRSGIVRHVALEVVNSAAQGGLIDLQALAYVKDGLLAYLRQVYGQDAGASDPPNIQNKIAQTITFLFSALYASGWESFFDDLLGLTQKSPSSTTRDNASGIIFYLRVINSIHDEIGDVLVSRSRNEQDKANALKDLIRQRDMQKITSSWQQILSEWRDGNDVIVEMCLKAVGSWVSWIDIGLVVNQTMLDLLFQQLGRAQKEDLRQGEEKVRDAAVDVFTEIIGKKMKPEDKIDMIIFLNLDTIVSQLSNSPPLHGNRFTFKYDTDLAETVAKLVNITVIDIVRALEQEGVSTECKEKANGLLQAFLPHILRYFSDEYDEVCSTVIPCVSDLLTYLRRIAKVNPALASQHSSILLPILKAIIAKMRYDETSSWGEEDEQTDEAEFQELRKRLGILQQMIASINEQLYMEVVSEMVATTFENLRQSGSQMDWRDLDLALHEMFLFGDLAVKAGSLYTKGNPNNQAAERLIEMMLRMVESDIRSFTHPATQLQYTEICVRYSSFFHHHTHLIPGVLENFLQLVHHPIKKVKTRSWYLFQRLVKQLRQYVGNVAQTVVEALGDLLVIRAELPSEVSEGDEMSSEDHELADAIFNSQLYLFEAVGIICSTPTISPDKQVLYVQAVLNPIFLDMEKNLEAAKSQDERAILQIHHDIMALGTLARGFSDWMPGTNTPATLPAPEVSAAFNQVAEATLVALESLKSSFNVRTAARFAFSRLIGVLGSRILPQLPRWIDGLLTQTSSRDEMALFLRLLDQVIFGFKGEIFSILDTLLTPFLQRVFSGIADPTTGTDDEIQLAELKREYLNFLLAVLNNDLGAVIISERNQPIFETVISTIEHFSKDIDDFTTAKMAFSVLSKMSSSWGGPDVIAEASNGTPPSQAPLPGFGQFMITRFSPLCWALPSTPSFNSKDAQAKQVLAEAGGLQRTIYAKTGMEYLTYLRDRELPGMGMGGELIEEFVGALSRLDLKGFRQFFPVCLSNFHILSI
What is the function of this protein?
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.  Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
What are the official names of this protein?
Exportin-T, Exportin(tRNA), Karyopherin-beta, tRNA exportin.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: RL32_HALHL
Sequence: MAVQQNRKTPSKRGMRRSHDSLSKPTLSTEQNTGETHRRHHISADGYYRGRKVTRGQDD
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: PLSX_EXISA
Sequence: MKLAIDAMGGDHAPKAIVEGVKRFVAQYPNESMELFLVGDEVKIASYGLDDPRVTVVPASEIITGEDEPVRAVRRKKDSSLVVAAQLVKEGKADALVSAGNTGALMAASLFIIGRIPGIERPALSPTFPTYTGSGVVVLDVGANPDAKAEHLVDYAIMGSLYAEHVRGIKTPRVALLNIGTEAGKGNALTKEAFPLLEQAPVHFVGNVEAREAMSGDVDVIVTEGFAGNILLKGVEGSSSMLMKMMKEQFTSDLVSKLAALILKPKLRRLKETLDYREHGGAGLFGINAPVIKAHGSSDALAIMSALKQAKIMVDHDVVEKIKRAKAID
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: HTPX_VIBC1
Sequence: MKRIMLFLATNLAVVLVLSVVLNIVYAVTGMQPGSLSGLLVMAAVFGFGGAFISLMMSKGMALRSVGGMVIESPRNETEHWLLETVGRQAQQAGIGMPTVAIYEAADINAFATGAKRDDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMVTMTLMQGVVNTFVIFLSRFIANIVASNDDEEGQGTNMMVYFGVSMVLELVFGFLASFLTMWYSRHREFHADAGAAQLVGKEKMIAALERLKMSHESQLDGTMMAFGINGKRSMTELLMSHPPLDKRISALRSQQY
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SUM1_YEAST
Sequence: MSENTTAPSDNITNEQRLPSGPKDDVDTLALTSAQNQANSLRKLDTDANAKALPSITDIPVSDDSDIKRQVGSGFGSNPLHIKDSEAFPHSSIEALKEGMDKVTKQCNDLKTALLSKDTSLTDSVQDLFNSLKVLSHNQSVLENKLDDVMKNQVNTDILVNNLNERLNKLSTMLQNTSKVNHSNLLIENSSNNTSSQHNTSSSRRGPGRPRKDASTSTMNKLVSNAASVNLKSASNQGAPFSPVNITLPTAVVQTSKSKRYFVEPSTKQESLLLSAPSSSRDDADMSLTSVPQRTNNENGKERPSTANSSSITPTPVTPNNLIQIKRKRGRPPKKRTVETMISNSTDTIDKSDASNRIKNEIPINSLLPSSKFHQIPSSPSNPVSQPAPVRTSRSATQEIDIKSLELASLISTNGDPNAEDSNTTDTVHNNVEGKVNVEENKTEKEKIITIKSSSENSGNNTTNNNNTDNVIKFSANSDINSDIRRLMVNDQFSLSYDASGNITVKLPPVSSPAAATAAAAAAVTSEMNRQQRELDKRRDSREKMLVNMKYNDRDKAKSFMESNKKLLKAMKEEERRKRMTSIIHDNHLNLNLNEISTRSKIKSAEKPTTKGSSMSPKPRSASISGISDHQQEGYQPLEQEKLVDIDNEGSNANSDSLKMGLTISAADTVHKVGIQSMLNSGEEAITKENAEYERKTPGDEETTTFVPLENSQPSDTIRKRTAGDDGALDQTENTSISPKKRRTEDHTKGEEDEGERGVGNSGTLATVENVSGDISADLSKGTSSIHNDTESANDSSNGNGNLGLGTESRNTLLTATPIELICREGFFYRRDIPDVPITTGAYLEFKFKAKEEELINSSINEEDYAAKSKHEKMNAHFFKPDIQEETELAFEILSKTTLTEKYVNSLEYFLMEFRWENKLVGLGLKLRESKRTWQRRKALFALFEFWRDQSRDKRRFHNYTILHAVKEMENYRIFINRSVSWFYNHITLLKMILYDLCDNVTTQWREWMFPHNETLPALGQDGINEDNLNETIDNMLIFDFLDDGSENNQVKYSRIIPPDIR
What is the function of this protein?
DNA-binding protein that specifically binds the regulatory region of middle sporulation genes (MSE).  Required for the repression of middle sporulation genes during vegetative growth.  Represses expression via the recruitment of histone deacetylase HST1.
What are the official names of this protein?
Suppressor of mar1-1 protein, SUM1-1 protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURL_BACCN
Sequence: MSLMLEPNPTQIKEERIYAEMGLTDEEFAMIEKILGRLPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTTGERVLQGPGEGAGIVDIGDNQAVVFKMESHNHPSAIEPYQGAATGVGGIIRDIFSMGARPVALLNSLRFGELQSPRVKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDPCYEGNPLVNAMCVGLIHHEDIKKGQAHGAGNTVMYVGASTGRDGIHGATFASEELSESSEAKRPAVQVGDPFMEKLLIEACLELIQSDALVGIQDMGAAGLTSSSAEMASKAGMGIEMYLDDVPQRETGMTPYEMMLSESQERMLIVVKKGREQEVVELFEKYGLAAVAMGKVTEDKMLRLFHKGEMVAEVPADALAEEAPIYHKPSKEAAYFREFQEMKMKTPKVDNYKETLLALLQQPTIASKEWVYDQYDYQVRTSTVVTPGSDAAVVRVRGTEKALAITTDCNSRYIYLDPETGGKIAVAEAARNIVCSGGEPLAITDCLNFGNPEKPEIFWQIEKSVDGMSEACRTLQTPVIGGNVSMYNERSGEAVYPTPTVGMVGLVHDLKHVTTQEFKQAGDLIYVMGETKAEFGGSELQKMMYGKIFGQSPSIDLEVEAKRQKQLLEAIQAGLVQSAHDVAEGGLAVAIAESAIGAKGLGATVKLAGEATAALFAESQSRFVVTVKREQQEAFEKVVEAIQVGEVTNTNEVTIHNEENEVLLTANVDEMRKAWKGAIPCLLK
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAHH_SINMW
Sequence: MSANQDYIVADIGLADFGRKEIAIAETEMPGLMACREEFGASKPLKGARITGSLHMTIQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAIAASGVPVFAVKGETLEEYWTYTDKIFQWADGGVSNMILDDGGDATMYILLGARAEAGENILINPGSEEEEILFAQIKKRLAATPGWFTKQRDAIKGVTEETTTGVNRLYQLQAKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRGTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEVDPICALQAAMDGYEVVQLEDVVSSADIFITTTGNKDVIRIEHMRAMKDMAIVGNIGHFDNEIQVSALRNLKWTNVKPQVDLIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFSNQVLAQIELFTKGENYKNEVYVLPKQLDEKVARLHLAKLGAKLTELSEEQAAYIGVKAQGPFKAEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFAP1_CHICK
Sequence: MSAPSALVKQPPIQSTAGACPSRNEKGRAVYGEGEGETVCVGKAAADYVPMESSEEEDEEFQFIKKAKEQEVEPEEQEEEVANDPRLRRLLQNRITEDVEERLARHRKIVEPEVVSGESDSEVEGEAWRVEREDTSEEEEEEIDDEEIERWRGMMRQRAQERKTEELEVMELEDEGRSGEESELESEYEEYTDSEDEMEPRLKPVFIRKKDRITVQEREAEALKQKELEQEAKRLAEERRKYTLKIVEEEAKKELEENKRSLAALDALDTDDENDEEEYEAWKVRELKRIKRDREEREAMEKEKAEIERMRNLTEEERRAELRANGKVVTNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the spliceosome.
What are the official names of this protein?
Microfibrillar-associated protein 1, Associated microfibril protein, AMF, Spliceosome B complex protein MFAP1.
What is the protein family that this protein belongs to?
Belongs to the MFAP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CDN2D_BOVIN
Sequence: MLLEEVHAGDRLSGAAARGDVQEVRRLLHSELVHPDVLNRFGKTALQVMMFGSPTIALELLKQGASPNVQDASGTTPAHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVREGHTSVVSFLATESDLHHRDATGLTPLELARGRGAQELMDILQRHTVAPL
What is the function of this protein?
Interacts strongly with CDK4 and CDK6 and inhibits them.
What are the official names of this protein?
Cyclin-dependent kinase 4 inhibitor D, p19-INK4d.
What is the protein family that this protein belongs to?
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: FLGH_LEGPC
Sequence: MNRLNIAVSCLATALLFGCEALHPPAPGDNPDYAPTYPVTPDPKELRKVSGAIYSSETALPLFETPRARHPGDILTVYLIEKTDAQKNATTTQRKNDTTKITNKLFLGRPISLGSGYSMDFDLDNQRQFNGEGRSIQNNKLAGSISVTVAKVLANGNMVVQGEKWVRINQGNEFVRLSGIVRPQDIKADNTITSDRIANARISYGGTGQINNTNAQGWLSRILWGPLFPT
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: THIM_NATPD
Sequence: MSDVDAAVDLAAALGDIDTATPLVNSVTNNVTVNDVANITLHWGGLPVMSDDAREVDDMVATADGCLINMGTVDEDGEESMVVAGTAANEGDKPLVVDPVGVGATPTRTRVANRLLDELDVTILNGNHGEITALAGDDADVRGVESVGEYADIAETALSCARTHDTVVVASGETDIVASPEEAYEITAGHPLMAQIVGTGCMLGVTLATFAAGMENATPLDAALAGTVGFGLAGEKAAEEGEYNGPASYKTAFLDTVAGLEAAPDDPAGRIERVLSVT
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: IRAM_ECOLX
Sequence: MNWIVIDTVIQPACDISFSAIWCNIKLILWYQSDIFLPPGCIFTPTRTGVILNNKELPVTIYNVTPFNKNVWNLIKSSQECPANTGNITDKCFNHRCILEICPYGRK
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.
What are the official names of this protein?
Anti-adapter protein IraM.
What is the protein family that this protein belongs to?
Belongs to the IraM/RssC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRVB_TRAJP
Sequence: MAFKGVLNDADVTAALDGCKSAFDHKAFFKACGLAAKSADDIKKAFAIIDQDKSGFIEEDELKLFLQNFCAGARALSDAETKAFLKAGDSDGDGKIGVDEFAAMVKH
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions.
What are the official names of this protein?
Parvalbumin beta, Dark muscle parvalbumin, aji-DPA, White muscle parvalbumin, aji-WPA.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: OR2B8_HUMAN
Sequence: MDQKNGSSFTGFILLGFSDRPQLELVLFVVLLIFYIFTLLGNKTIIVLSHLDPHLHTPMYFFFSNLSFLDLCYTTGIVPQLLVNLRGADKSISYGGCVVQLYISLGLGSTECVLLGVMVFDRYAAVCRPLHYTVVMHPCLYVLMASTSWVIGFANSLLQTVLILLLTLCGRNKLEHFLCEVPPLLKLACVDTTMNESELFFVSVIILLVPVALIIFSYSQIVRAVMRIKLATGQRKVFGTCGSHLTVVSLFYGTAIYAYLQPGNNYSQDQGKFISLFYTIITPMINPLIYTLRNKDVKGALKKVLWKNYDSR
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Putative olfactory receptor 2B8, Hs6M1-29P.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: QUEC_SYNR3
Sequence: MSSTTIALLSGGLDSATAAALAREAGHRVIGLSFDYGQRHQRELRAAAEVAQALGLAEHHTINVNLAAWGGSSLTDLDQPVPDQGVQDGVIPSTYVPGRNTVFIALGLSLAEAKGAERLVLGVNAIDYSGYPDCRPDYLDAYQHLADLASRSGREGHGTQLWAPLVEWSKTKIVEEALRLNVPIASTWSCYAGGDHPCGVCDSCRIRDAALREAGRPDLASR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: NFUA_PHOPR
Sequence: MSMITITESAQQHFGKLLAQQPEGTNIRVFVVNPGTQNAECGVSYCPPEAVEASDTKIELELFDAYLDELSLPFLDDAEIDFVTDKMGSQLTLKAPNAKVRKVSDDATLMERVDYAIQTQVNPQLAGHGGNVSLAEITEDGVAILQFGGGCNGCSMVDVTLKEGIEKELLAQFAGELTGVRDVTEHARGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: ATPL_SHELP
Sequence: METVLGMTAIAVALLIGMGALGTAIGFGLLGGKFLEGAARQPEMAPMLQVKMFIVAGLLDAVTMIGVGIALFMLFTNPLGAML
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRC_ECO8A
Sequence: MTAPSQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHNFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSIDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVKQ
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: COR1A_HUMAN
Sequence: MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDTGRRRAAPEASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK
What is the function of this protein?
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion.  In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
What are the official names of this protein?
Coronin-1A, Coronin-like protein A, Clipin-A, Coronin-like protein p57, Tryptophan aspartate-containing coat protein, TACO.
What is the protein family that this protein belongs to?
Belongs to the WD repeat coronin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).
Protein: ATPA_NICTO
Sequence: MVTIRADEISNIIRERIEQYNREVKVVNTGTVLQVGDGIARIHGLDEVMAGELVEFEEGTIGIALNLESNNVGVVLMGDGLLIQEGSSVKATGRIAQIPVSEAYLGRVINALAKPIDGRGEISASEFRLIESAAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAIGQKASSVAQVVTTLQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYRERHTLIIYDDPSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSSLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNSGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFAQFASDLDKATQNQLARGQRLRELLKQSQSAPLTVEEQIMTIYTGTNGYLDSLEVGQVRKFLVELRTYLKTNKPQFQEIISSTKTFTEEAEALLKEAIQEQTDRFILQEQA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: TRMBR_HALSA
Sequence: MSDEDLRGTVEQVGRGFNLGEYEVEAYLTVLRHGELTASDIADRTDIPQPRVYDTVRSLGDRGLVELRESRPMKIVALSPEDAFAGLQEDFQEMVGALEAEYTQPARNTEAVSLVKSRSTIVRYFGDVIAEADFELVCSLTPSLLERFADDLAAAVDRGVSVDVVVSPARNAPNPDAFDYAAATTAARGRRGITTPVIAVADGRYSVYATQDAVRDDSDRYGVIFDQSALGFLVSGFFDTVLWSTATESLYDPATELSLPRTYAAIRRCVRDLQSVDESVYATVTGRDVLTGADRRIQGRIVETRFEESGEVATIIVYTENGDRVEVGGRVAALEDVEAHEIAVARDAPPAL
What is the function of this protein?
Coordinates the expression of genes functioning in central metabolism and its associated pathways.  Acts as both a transcriptional activator and a repressor in response to carbon source availability.  Binds to an inverted palindromic sequence in the promoters or ORFs of target genes.
What are the official names of this protein?
HTH-type sugar sensing transcriptional regulator TrmB.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulator TrmB family.
Protein: ATPL_CLOBL
Sequence: MDPKAFVSGMAALGAGIAALACIGAGIGTGNATGKAVEGVSRQPEASGKIMSTLVIGSAFSEATAIYGLIIALFLIFKI
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HCP_YERPB
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLVAVLQGLSAWALQARELGIIDSQIDSFAPRAFFSTLTNVNFDSDRIVEYAKDAILLRHSLAVRCRLLDSTITVDHPLAELQLVADDIPSLLQQSQQFALNNDKADVGDDIHGLRMLCLYGLKGAAAYMEHAHVLGQSDEQIYAEYHAYMAWLGTQPRDVDTLLNNAMGIGKMNFNVMAILDQGETQAYGDPQPTSVNVRPVAGKAILISGHDLKDLHMLLEQTQGTGINIYTHGEMLPAHGYPELKRYPHLVGNYGSGWQNQQTEFAKFPGPILMTSNCIIDPNVGNYGDRIWTRSIVGWPGVNHLDGENFAPVIEQALGMAGFPYSELEHLITVGFGRQTLLNAADTVIDLVASKKLRHVFLVGGCDGSRTERSYFTDFARSVPQDCIIMTLACGKYRFNKLDFGTLEGLPRLLDVGQCNDAYAAIMLAVKLSEKLGCTVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIYTGPTAPGFLTDNLMAILYEKFGMQPITTVEQDMQAILGH
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENDA_SULAC
Sequence: MIQGEILGDKVLINDVEKAKEIYKLGYYGKPLDITKPKSPEDIKKPLILSLIEALYLSKKKIIEVIRDGKVIDDALLYKIGMENIPRFELLYTVYEDLREKKFVVRSGMKYGADFAIYTVAPGLEHAPYLVIAIDEEQEISPNEILGFGRVSHSTRKNLILSIVNQRNRSIRYIMFKWLKL
What is the function of this protein?
Endonuclease that removes tRNA introns.  Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini.  Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
What are the official names of this protein?
tRNA-splicing endonuclease, tRNA-intron endonuclease.
What is the protein family that this protein belongs to?
Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
Protein: YIDD_MANSM
Sequence: MATSHSLGEKILVKLIRFYQLAISPMIGPRCRFTPTCSCYGIEAIKTHGALKGSWLTLKRILKCHPLSKGGYDPVPPKINNNVEKK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATG5_ASPCL
Sequence: MENQASLNSIQKTVWDGKLPLQITLASSESRTFDQTDPYLISCPRISYLPSLLPRLRSFFASSLIEPKSQPHEGWFSFEGVPLKWHLPIGLLYDLYAGADPASKGSRPDESEQIISSVGDTLPWRLTLHFSDWPDEELVRLDADGMVMHDAFINSVKEADFLRNGTAKGIMSLSKEDSSGLWEAVQDVDLPSFQRISNILLPAPNQPFRNVPIRFFLPLPPDSGSPSLKVVQSPLPPSIPASTANATQSTVLRGKPASQLQTIGSALHSLLPNLFPSRRTPVLAKPVLHGAAVPMSAPVEEVARSAAYGDGWVYIVVRMMG
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy).  Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production.  Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function.  The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Autophagy protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATG5 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.