PharMolix/UniProtQA huggingface dataset:
Protein: BBS10_MOUSE
Sequence: MASQGSVTAALRVAEVLESIANRCVGPEGGQVLCTKPTGEVLLSRDGGCLLEALHLEHPLARMIVACVSSHLKKTGDGAKTFIIFLCHLLRGLHAIGEKGKDSFTSENIQSHERHWKNCCQWKSISQALQTFQTQTLGCIVDRSLSRHYLSVFSSSTEGRKLCRHSLELLLEAYFCGRVGRNNHRFISQLMCDYVFKCMACESGVEVFELLDHCFAELNVGVTGLPVSDSRIIDGLVLPRDFSMYCPADGDIRMVIVTEILQPQFSSAGSEFVLNSETQFQASQCWITDRTKTVMNHLRGQNVKLLLTSVKQPDLVIYCARLNSISVVECLSAEEVSLVQRITGLSPCVLPEVASQCEISDSTLVKFCKPLILRSKRYVHLGLISTCAFIPHSMVLCGPVLGLVEQHERAFHGAFKMLRQLFTDLDLNYIIQTKQQCNPSPLAYDNSRERNHSPETDKYQDIVAKSKNKLETQTHLEVYSGLGASDTELRAGKPWSAHKKTPIAPSQTDEMLKCLPPERSGIIDNCDLSIENHSTGNPTAEDTGTEISFEHLQVSDNAGKGYTLPVMRKSLDTCTCQGYCSSTVPAGCVLPVGGSFEILMSYYLLSYAKQCRQSDETVISMLIADALLGIPKILYKPKKGKDSFPHIYMRSLHALQASQPMVSGQSGFESVAGKYQLLTSVLQCLMKILTIDLIINIKRQPQKTADQESEDEF
What is the function of this protein?
Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis.  Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.  Involved in adipogenic differentiation.
What are the official names of this protein?
Bardet-Biedl syndrome 10 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Located within the basal body of the primary cilium of differentiating preadipocytes.
Protein: HAUS3_HUMAN
Sequence: MSCGNEFVETLKKIGYPKADNLNGEDFDWLFEGVEDESFLKWFCGNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLED
What is the function of this protein?
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
What are the official names of this protein?
HAUS augmin-like complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the HAUS3 family.
Protein: VEA_ASPFU
Sequence: MATRPPLMPPANETESSVSRISREGKKITYKLSVMQQPERARACGAGAKSSADRRPVDPPPVVELRIFESDPNDDLHKTDITFAYNANFFLFATLETARPMAQGRLTGPPTCPVLTGVPVAGVAYLDRPQQAGYFIFPDLSVRHEGRYRLSFHLYEEIKDIKDADKDTPMPDLNSSTNLTKPSAPKAHLNFRLEVKSVPFTVYSAKKFPGLATSTSLSRIIAEQGCRVRIRRDVRMRRRGEKRTDDYDFDDERAFATRSDRYTTPDMYAANSAERARSTSISTTADTSFPYGSDAQRRPSAGDYGFQGAQPYQRSMPAASAAPAPAPVHSPATSAQTSSYQSHLSFGATQSQYPAPQLPPTPQSATPTNTYSPHPSYSHSRNPSNGTEYDATSSGYPYPQPRLPADRPSYSKAALPPLRLEPPKAPNMQTSTDSRSSDANAYPTLSQPPVPRAPTPANHVTSLPPLKVLSGEYSHPSQPNAQSPHHDLGSGKRLLWETNHTLSKRSHEETFGSDERPLHNGMRPDMDQYPSMGRKQPDYGRLPFYTDSRDEMAYKRANGRMVMKILPALP
What is the function of this protein?
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity).  The velvet complex hat acts as a global regulator for secondary metabolite gene expression (By similarity).  Controls the expression of hundreds of genes, including those comprising more than a dozen known secondary metabolite gene clusters (PubMed:24116213).  Controls the expression of the gliotoxin gene cluster (PubMed:23087369).  Controls the expression of the fumagillin, fumitremorgin G, fumigaclavine C and glionitrin gene clusters (PubMed:24116213).  The regulation of the fumagillin gene cluster and fumagillin production is performed through direct control of the expression of fumR (PubMed:24116213).  Negatively regulates conidiation (PubMed:22970834, PubMed:23087369).  Required for normal protease activity (PubMed:23087369).
What are the official names of this protein?
Developmental and secondary metabolism regulator veA, Velvet complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the velvet family. VeA subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Enriched in the nucleus in the dark (By similarity).
Protein: KCY_LACLS
Sequence: MKKIQIAIDGPASSGKSTVAKIIARNLGLIYLDTGAMYRVATLVALQEKTEDASKIIQFIENHPISFANGKNGQEVLVGLDNVTEVIRTNEVTNAVSKISAMVEIREFMVAEQQRIAQKGGIIMDGRDIGTVVLPQANLKIFLVASVDERAERRYKENLSKGIPTDLERLKVEIAERDRKDSIRVVSPLKQAEDAILLDSTGKTIKEIVQFIEEKAKKLM
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTM1_YARLI
Sequence: MTNQESQSVKVVFVTRDETLQPEAPLPPVMVPTSLKRLGLSEIVNQLLDTETPVPLDFLIVKATAGDGGASILDEESASSSSVLLRPGASLESFLADNGLSSEVSLSIEYIRSVLPPSFLASFSNPDWVAAVDINARWTGDLKPVIASGSYDGVVRLWDHSGHVTGQLVGHNSAAKAVRWISNDQLVSGGSDRLLYLWNPDGKKYRRKEPGQVGKKELNYDSEEDSDEEMLDELPAASTVTPMAALHGHTAPINDLAVHAKTGKIISASADGSVGLWSTDYNDMPAIEPHTAAAGGLTSTSAQKRRKLANSGSGATGLGAARQRGPLAVMGGHSAAVSAVAFHHSDPTVAYSVSLDHTIKTWDLATAEAVQSNAGSPDPSVDTRSTSFSLLSLCTLPQGLIACGSSARHITLHDPRVTAQVATQAKLVGHTNFVSSLSRGPESNPFLLASGSHDGTVRIWDVRTTKSLHVIHRETLTENNAVFGVDWKQNLGIVSGGQDNKIQINNNPQSA
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein YTM1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR12/YTM1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: HIS1_BACC0
Sequence: MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATYVEHGVADIGVVGKDILMENEKDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPHITSNYFHNKGEDVEIIKIEGSVEIAPILGLADAIVDIVETGKTLQENGLIVFEEMYSISARMIVNKAALKTKKDEIFSIVNMMEQEILSGK
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_ORITI
Sequence: MNPNLNIEQDNASEIIAGVDEAGRGPLAGPVVAAAVVVNQSIMIDDIKDSKVLSKSKRESCYDKITNNYYYSIGIASVQEIDKYNILEATKLACIRAVKNLAIIPTKVLVDGNMNFTDNRFISIVRGDQICYSIASASIVAKVTRDRMMQILHQEYPVYGWNQNCGYGTKLHIEAIKTYGQTIHHRVSFKFKGNINHSAILGNMV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHK_HELAN
Sequence: MNSIEFPLFHRTTQNSVISTTLNDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAIIDAITKLRKKISREIYPDRIMSQRENRCFTTNHKFQVGHSIHTGNYDQGFLYQPPSTSEIPPETFFKYKSSVSSHELVN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RUVA_STAAM
Sequence: MYAYVKGKLTHLYPTHVVVETAGVGYEIQTPNSYRFQKHLDHEVLIRTSLIVREDAQLLYGFSSEEEKDMFLSLIKVTGIGPKSALAILATSTPNEVKRAIENENDTYLTKFPGIGKKTARQIVLDLKGKVKITEEDSDSLLQVDATSTVQDQFVQEAMLALEALGYSKRELAKVEKTLNKNKYDSVDEAVKAGLQLVVS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: IDI2_LACP3
Sequence: MTQSQQSHRKDEHVFLAEKYFQSVAHAGFDQVRLLHRALPETTMAAVDLKPDLPFNWQWPIYINAMTGGSPQTGKLNAQLGQLAQALGVAIASGSQSVALRDPQLVPTFATLRDHDPNGFILANVGAGHHATAAEAAVAMLKANALEIHLNAAQEVVMPEGDRDFMWQANIKSIIATSQVPIVVKEVGNGFIREDLQSLQQLGVQFVDVGGRGGTNFATIENARRSGHDFAYLQDWGQTTVESLLEARGLGLTMLATGGVRSPLDVVKALRLGAHAVGMSGMVLHHLIQTGYEATLAYFQNFLHQLRQLYALLGVTNWQELQEAPIVLSADLEHYRQARGLPGI
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METC_HAEIN
Sequence: MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQRRAKGELFYGRRGTLTHFALQDLMCEMEGGAGCYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITMEIPDIPTIVKAARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYLMGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRLTSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
What is the function of this protein?
Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis.
What are the official names of this protein?
Cystathionine beta-lyase, CBL, Beta-cystathionase, Cysteine lyase, Cysteine-S-conjugate beta-lyase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YUAV_ECOLI
Sequence: MSAFTFSPSRHDGPGTEVYGRPPGILSAQLSYPAAAPPAVFFPGADFPGTYSFRSYPQNLWITVAPLLREKALLTA
What are the official names of this protein?
Uncharacterized protein YuaV.
Protein: MIRC_EMENI
Sequence: MPLLEPSATAYGTFGDMRPDTEDEGERLLTDGYVSDDDGSAVTSVDSVQEGVRKIEAINITWTTRSLVIAYISIFLMAFCTSLEGQTIMSLSAYATSAFSKHSLISTVLVVQNVVNAVIKPPMAKIADVFGRFEAFCVSILIYVLGYIQMAASTNVQTYASAQIFYAAGSTGLQILQQVFIADSSSLLNRALLALLPELPFLVTVWIGPTIADVVLENSSWRWGYGMWSIILPASFLPLALSLLLNQRKAKRLNLIKERPHHRRGFVAAVRRTWYDLDIFGLALLSAAVTLILVPLTLAANTKNGWKSNSIVAMIVIGVVCLILLPFWETSKKLAPKPLLSLHLLKQRTALAGCCLAFFYFMAFYFSVQPYLYSYLQVVQGYDVATAGRVTQTFAFTSTIAAFGVSILIKYTRRYRVYVTLGCVIYMTGLLLMLLYRKEGSSPLQVLGTQVIVGMGGGLLNVPVQLGVQASASHQEVAAATAMFLTSMEMGGAVGAAISGAVWTHNIPRKLNLYLPDEYKSEAGAIFGKLTKALSYEMGTPVRSAINRSYQETMNKLLVLALLATLPLIPLSLLMSNYKLDKMSESSDHDDASPRNGLGPGERAKRT
What are the official names of this protein?
Siderophore iron transporter mirC, Major facilitator iron-regulated transporter C.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HIS6_YERP3
Sequence: MLAKRIIPCLDVKDGQVVKGVQFRNHEIIGDIVPLAQRYAQEGADELVFYDITASSDGRVVDKSWVARVAEVIDIPFCVAGGIKSVEDASQILTFGADKISINSPALADPTLITRLADRYGVQCIVVGIDTWYDTESDSYQVYQFTGDEKRTKATTWQTEDWVKEVQLRGAGEIVLNMMNQDGVRNGYDLRQLQQMRAICHVPLIASGGAGTPDHFLEAFRDADVDGALAASVFHKQIINIGELKKYLSEQGVEIRVC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_TRIL1
Sequence: MSTVLRFGIPKGSLEEATVDLFKQAGWQIGISSRSYFPTVDDGEMKCHLIRPQEMGKYVERGTIDVGIAGRDWIRENDSDVVEVCEMVYSKVSRRPVRWVLVVAQDSPVQGPEDLQGATISTELVEFTKRYFKERNIQVNVEFSWGATEAKVVDGLCDAIVEVTETGSTIRANNLRIVCDLMESVPVMVANKAAWEDPWKRAKIEQIATLLNSALRAEGMVGLKLNAPAEKVEAITGILPSQKAPTVAHLYKSDWVSIESILPEKEVRRIVPELLRLGAEGIIEYPLSKII
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHEB2_RHOCS
Sequence: MNDSPGRTTVSGPSGGSDPFRVMVVDDSAVIRGLITRALESDPEIKVVASVANGQMAINTLSRQPIDVIVLDIEMPVLDGLSALPHLLQADPNVKIVMASTLTAKGADISLRALRAGAADYIPKPSSTRELTGADTFKRELTEKVKALGAAARRSGPRREGTAAARPPGAAAQPTSGYTLPSPVRAKPETGPLTVRPLPPDGRPDVIAIGSSTGGPQALFEVLGHLRGATQPILITQHMPATFTTILADHITRQCGIQCAEAKDGEPIVGGRAYVAPGDFHFLVVNRNGVPTVQLTKDAPENFCRPAVDPMLRSIVRQWGRRVLSVILTGMGHDGQKGCESVVQAGGVVIGQDEATSVVWGMPGAVATAGLCSAILPLKEIGPFIQKIAARRAA
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase of group 2 operon.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_BORBR
Sequence: MALRPLHDRVIVKRLDNERKTASGIVIPDSAAEKPDQGEVVAVGPGKKTEDGKILPVDLKAGDKVLFGKYAGQTVKVDGEELLVIREDEILAVIQ
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADW5_ALLMI
Sequence: VKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVKEAGGLRLKHMADYPDYKYRP
What are the official names of this protein?
SRY-related protein ADW5.
What are the subcellular locations of this protein?
Nucleus.
Protein: IOLG3_SACEN
Sequence: MTVRVGVIGTGMIGQDHIRRLTRVVTGAEIVAVTDIDADRAASVAGGVGARTMPSGADVIGSADVDAVLVTSWGPTHAEHVLAAIEAGKAVFCEKPLATEVEDCLRIVEAESARGKRLVQVGFMRRYDAGYREMKELVDAGGIGTPLMAHCVHRNPTVPETYHSAMAAQDTAVHEIDTLRWLLDDEIVSAQVIRPRRTSKRFEHLQDPQIMLFETESGARIDVEVFVNCQYGYDIQCEVVGESGTVRLPDPARTGLPSAGSVRAAITQDWKQRFADAFDAELQSWVDSVAHGAAGGPSAWDGYAATAICGATVEALHSGQVVPVALKDRPGLYGGNNQ
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
What are the official names of this protein?
Inositol 2-dehydrogenase 3, Myo-inositol 2-dehydrogenase 3, MI 2-dehydrogenase 3.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: CYP1B_MAGO7
Sequence: MMTPTELITHYRIVQHSFAPLRLSWWETNRVIAVQIWRDSSFFTRILIAFIGLCLLSIFSRLTRPRSLRRLGIPGAVQPRFSTWSLDFKKVLEDSAKKYPNSPFCLNAFGTEYAVLPSKCYDEVKRLPEHQASAFAFFREAFHGAWTGAGVQTPELGRTIAVELTRGIPSLVHWRQMDCAEAFKMCIGEPSEWREIQLFEAIQRIVISVNSSSFVGRELGTNQNWLRLIYNMPLQLGIPTVILGWTPFLLQPLLKPFLFAPLRMTQRKIKSMLRPVLENDVQEYEASSDKKNLLSPKEQGKVQLTGWLLSRYKGKLDFEVLLQDFITVLFESTPSTASTLFHVVCELAADPALQDMLRQELEEHTDNGSLPQTHLNELRKMDSVMRESARASPFSYLVLYRKLSIPTKLSMGPELPAGTNICVDAHHINTSPDLWDQPHTFDGLRHYRARQQPQNENRYKFANLGSDAPSWGDGLQACPGRMFADNTIKIILTHLLLNYDVKLRPGESKPEKGAMPNGSIVPDVWAKVLFRSRASSAVNEGKK
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of a tyrosine-derived cytochalasan acting as a fungal signal recognized by resistant rice plants and leads to avirulence in Pi33 resistant rice cultivars (PubMed:18433432, PubMed:31644300).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS ACE1, assisted by the enoyl reductase RAP1, that are responsible for fusion of the tyrosine precursor and the polyketide backbone (PubMed:29142718).  The polyketide synthase module (PKS) of ACE1 is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the tyrosine precursor (PubMed:29142718).  Because ACE1 lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase RAP1 (PubMed:29142718).  Reduction by the hydrolyase ORFZ, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ORF3 then yield the required isoindolone-fused macrocycle (Probable).  A number of oxidative steps catalyzed by the tailoring enzymes identified within the cluster, including cytochrome P450 monooxygenases CYP1 to CYP4, the FAD-linked oxidoreductase OXR2 and the short-chain dehydrogenase/reductase OXR1, are further required to afford the final cytochalasans that confer avirulence and which have still to be identified (Probable).  The monooxygenase CYP1 has been shown to be a site-selective C-18 hydroxylase whereas the function of CYP3 is the site-selective epoxidation of the C-6/C-7 olefin that is present in some intermediate compounds (PubMed:31644300).  Finally, SYN2 and RAP2 are not required for avirulence in Pi33 resistant rice cultivars (PubMed:18433432).
What are the official names of this protein?
Cytochrome P450 monooxygenase CYP1, ACE1 cytochalasan biosynthesis cluster protein CYP1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AZOR_RHOPB
Sequence: MKLLHIDSSVLGPHSVSRQVSAAIVARLREVNPGAAVTYRDLGASPLAHLSGAHLAVAQGAVPAPELQDDLAAGAAVLEEFLAADTVVIGAPMYNFTIPTQLKAWIDRILVAGKTFSYSGGTVQGLAAGKRVIIAISRGGFYGPDTPMAVGEHLESYLRFVFGFIGITEPDIIAADGIKFSPEHREKAIASALSAVTALRAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: IZUM4_HUMAN
Sequence: MALLLCLVCLTAALAHGCLHCHSNFSKKFSFYRHHVNFKSWWVGDIPVSGALLTDWSDDTMKELHLAIPAKITREKLDQVATAVYQMMDQLYQGKMYFPGYFPNELRNIFREQVHLIQNAIIESRIDCQHRCGIFQYETISCNNCTDSHVACFGYNCESSAQWKSAVQGLLNYINNWHKQDTSMRPRSSAFSWPGTHRATPAFLVSPALRCLEPPHLANLTLEDAAECLKQH
What are the official names of this protein?
Izumo sperm-egg fusion protein 4, Sperm 22 kDa protein c113.
What is the protein family that this protein belongs to?
Belongs to the Izumo family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS8_BACSU
Sequence: MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCSEAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFLNDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICSPNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMILRTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCVEQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALGFPTSLRITIGTKEQNEEILAILAEIL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: RR11_POPTR
Sequence: MAKLLPRIGSRKNGRISSRKNARKIPKGVIHVQASFNNTIVTVTDVRGRVISWSSAGACGFRGTRRGTPFAAQTAAGNAIRTVVDQGMQRAEVMIKGPGLGRDAALRAIRRSGILLSFVRDVTPMPHNGCRPPKKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RDGC_NEIG2
Sequence: MWFKQISFYPLNKEKLPEADVLADKLAEAEFTHCQGLDWFSEGFTAPVSFSPELVFPADFTLRVALKKEEKVLPAGVIRDILEEKVAEIQNNEARNVGRKEKQELKEQITDDLLPRAFTRSSRTEAVFNTRHGYLLVNNAASAKAENILTKLREALGGLEASLPNTKQSPSSLMTGWLLQGHCEGGFELDSDCELKGTGDIVPVVKVSKQDLTADEVVQHVKNGKTVTRLGLVWREQIAFILTQDFTLKRIQYLDVLQEEAESNGDDAAGLAFASQILMAESVSTMLEELVSYLGGWQD
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL9_BURCJ
Sequence: MQIILLEKVANLGNLGDIVKVKDGYARNFLIPNRKARRATKEAIAEFEVRRAELEKIAAEKLAASQAVGEKLNGQSFEITQKSGVDGRLFGSVTNGDVAELLKKAGYEVEKLQVRMPEGPLKMIGEHNVQVALHTDVVVDVTINVIGDHA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: STP3_ARATH
Sequence: MVAEEARKEAMAKSVSGGKITYFVVASCVMAAMGGVIFGYDIGVSGGVMSMGPFLKRFFPKVYKLQEEDRRRRGNSNNHYCLFNSQLLTSFTSSLYVSGLIATLLASSVTRSWGRKPSIFLGGVSFLAGAALGGSAQNVAMLIIARLLLGVGVGFANQSVPLYLSEMAPAKYRGAISNGFQLCIGIGFLSANVINYETQNIKHGWRISLATAAIPASILTLGSLFLPETPNSIIQTTGDVHKTELMLRRVRGTNDVQDELTDLVEASSGSDTDSNAFLKLLQRKYRPELVMALVIPFFQQVTGINVVAFYAPVLYRTVGFGESGSLMSTLVTGIVGTSSTLLSMLVVDRIGRKTLFLIGGLQMLVSQVTIGVIVMVADVHDGVIKEGYGYAVVVLVCVYVAGFGWSWGPLGWLVPSEIFPLEIRSVAQSVTVAVSFVFTFAVAQSAPPMLCKFRAGIFFFYGGWLVVMTVAVQLFLPETKNVPIEKVVGLWEKHWFWRRMTSKRDIQETTILSH
What is the function of this protein?
Mediates an active uptake of hexoses, probably by sugar/hydrogen symport.
What are the official names of this protein?
Sugar transport protein 3, Hexose transporter 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.