PharMolix/UniProtQA huggingface dataset:
Protein: ITR2_YEAST
Sequence: MKNSTAASSRWTKSRLSHFFPSYTNSSGMGAASTDQSSTQGEELHHRKHCEEDNDGQKPKKSPVSTSTMQIKSRQDEDEDDGRIVIKPVNDEDDTSVIITFNQSISPFIITLTFVASISGFMFGYDTGYISSALISINRDLDNKVLTYGEKELITAATSLGALITSVGAGTAADVFGRRPCLMFSNLMFLIGAILQITAHKFWQMAAGRLIMGFGVGIGSLISPLFISEIAPKMIRGRLTVINSLWLTGGQLIAYGCGAGLNHVKNGWRILVGLSLIPTVLQFSFFCFLPDTPRYYVMKGDLKRAKMVLKRSYVNTEDEIIDQKVEELSSLNQSIPGKNPITKFWNMVKELHTVPSNFRALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFVFTLIAFFCIDKIGRRYILLIGLPGMTVALVICAIAFHFLGIKFNGADAVVASDGFSSWGIVIIVFIIVYAAFYALGIGTVPWQQSELFPQNVRGVGTSYATATNWAGSLVIASTFLTMLQNITPTGTFSFFAGVACLSTIFCYFCYPELSGLELEEVQTILKDGFNIKASKALAKKRKQQVAEGAAHHKLKFEPTQEIVES
What is the function of this protein?
Minor transporter for myo-inositol.
What are the official names of this protein?
Myo-inositol transporter 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RASP_ALKCK
Sequence: MNTLLAFIAIFSVLVFVHEWGHLYFAKKAGILCYEFAIGMGPKLFAFERNDTIYTIRLLPIGGYVRMAGEEPEQPTIRPGYEIGLVLDEKDTVKELIVNNKSKHPEAQVVQVERIDLVHDLFVETIDEDTGELVRYPIDEKAFIVQDEVAQIIAPWKRQFGSKPLPKRAMAIFAGPLMNFILGFVILLGLSLYQGVTLSSEIVINGENSPAEAAGLQDGDVITAVNGVEVDSWKEMTTEVKKYPGEEVSIDYERNGEALQTNATLSQVEVMPDEYEGFLGVSGVPEFSLLGSLQYAGNEFINMATSIFDTLGLIFTGQFSLDYISGPVGIYDITDQAVSLGIQTVIFFAALLSINLGVINLMPIPALDGGRLMFLAYEGIRGKPVSPEKEGAIQFIGFALVMLLMIVVTWNDISKLFS
What is the function of this protein?
Is responsible for Site-2 cleavage of the RsiW anti-sigma factor.  This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).
What are the official names of this protein?
Zinc metalloprotease RasP, Regulating alternative sigma factor protease, Regulating anti-sigma-W factor activity protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CCL22_MOUSE
Sequence: MATLRVPLLVALVLLAVAIQTSDAGPYGANVEDSICCQDYIRHPLPSRLVKEFFWTSKSCRKPGVVLITVKNRDICADPRQVWVKKLLHKLS
What is the function of this protein?
Chemotactic for activated T-lymphocytes.  May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.
What are the official names of this protein?
C-C motif chemokine 22, Activated B and dendritic cell-derived, CC chemokine ABCD-1, Small-inducible cytokine A22.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL15_METMP
Sequence: MIRKSKKITKKRGSRTCGYGEAKKHRGAGHRGGRGNAGHQKHKWLSVCKFNPDYFGKYGFNRNPCLIKQLETINIGELEEYILKYKDAFQVEEGKVVVNATEIGFEKVLGKGRISTAMVVKAVEFSEGAKEKIEAAGGEFVEL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: TCPG_TETPY
Sequence: MFQGGHQPIMVLNQNTKRESGKKAQLANISASKAVSEIVTSTLGPRSMLKMLLDPMGGIVMTNDGNAILREIDVNHPAAKSMIELARVQDEEVGDGTTSVIIMAGEMMSAAKPFIERDIHPSIIVTAYYRALEESIKKIEELAVPIDVNNDDQVNKALSSCIGTKFTSRWGKLITDLALKAVRTIMRGGNLQKLNLEIKRYAKVEKIPGGTLEDSVVLDGVMFNKDITHPKMRRFIKNPRVILLDCPLEYKKGESMTNLEMMKETDMTDALQQEMEELALMCNDILKHKPDVVITEKGVSDLAQHYLLKQNVSVIRRVRKTDNNRISRVSGATIVNRPEEIQESDVGKKCGLFEVKLIGDEYFTFMTECENPEACSIILRGASKDVLNEMERNLHDCLAVAKNIFVNPKLVPGGGAIEMEVSSHLEKISSSIEGLHQLPFRAVAYALEAIPKTLAQNCGVDVVRNITELRAKHNQEGNKFIGIEGNSGKITDMGEANVWEPIAVKLQVYKTAIESACMLLRIDDVVSGLKKQKVAKGGASVTDGNGQEIPETFGDARDG
What is the function of this protein?
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.  Known to play a role, in vitro, in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit gamma, TCP-1-gamma, CCT-gamma.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F177A_MOUSE
Sequence: MERESGCAAAGETEAAAATAFRDATRQISNERGFENVELGVMGKKKKVPRRVIHFVSGETMEEYSTDEDEVDGLDKKDVLPTVDPTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAERQYQQNKLQADSIVQTDQPETVSSSFVNINFEMEEDCEAIKENKQRPVSVPP
What are the official names of this protein?
Protein FAM177A1.
What is the protein family that this protein belongs to?
Belongs to the FAM177 family.
Protein: SIA4B_MOUSE
Sequence: MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGALGGTHRVKLVPGYSGLQRLGKEGLLGRNCACSRCMGDASTSEWFDSHFDGNISPVWTRDNMNLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN
What is the function of this protein?
A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8144500, PubMed:9184827).  Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage.  Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8144500, PubMed:9184827).  Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (PubMed:22735313).  Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (PubMed:32030804).  Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (By similarity).  Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8144500).
What are the official names of this protein?
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2, Alpha 2,3-ST 2, Beta-galactoside alpha-2,3-sialyltransferase 2, Gal-NAc6S, Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase, Monosialoganglioside sialyltransferase, ST3Gal II, ST3GalII, ST3GalA.2, Sialyltransferase 4B, SIAT4-B.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (By similarity). Secreted into the body fluid.
Protein: Y2755_YERE8
Sequence: MDNASKPTFQDVLEFVRMFRRKNKLQREIVDNEKKIRDNQKRVLLLDNLSEYIKPGMSIEEVQAIIANMRVDYEDRVDEYIIKNADLSKERRELSKKLKAMGEVK
What are the official names of this protein?
UPF0265 protein YE2755.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: LST2_DROGR
Sequence: MDTFRKWLNKPKADDKSLLARFYHADRSLTAVASELDSFDGRAEPDRCTRLVSRLRQNQDKVLAITNMIMEELLGEDRDPRAFRAKFPEEVLQENLAGQLWFGAECLAAGSSILNRESESKEMRPLAQAVTKSLGHVRVLLRDQCLRNNVPNSKTLHLDFNDSNTEQLYESLKIFDHLFAEFELSYVSAMVQVKSRHEYEMQQWIGVLFSETLQRSLKVGLLDQDMVDAFDPGLMFSIPRLAIVAGLVVYAKGPLNMDMPGDQLSEMFRPFRTILIKIRDLLRNLSKQELYQLEKLLCTNEDINTKVPLGSSSIEAPSPEHNNSSSTTNTSNNNNNNTNNNNSSSGSDCTNNDKTGTTTNTHKPVERLVDHRNNNTTNSQQTSSCSVNAAATTPATSSRTRTPPSILSPSAGSTPTASPAPSPTPSHSIASTSSAATTSTNSPAHWSDYDDDDEDDDDDDVHADVEEDEDESGILDSDEHDLNDDSDSEVDEFFEAQLKAIVAAVDCAPGYLIPDCASGYLISNTNLGNLLQPQQVPLTDNFVASEDDELGNPTAVDQQQQPQQQLEHHQQQLQQQQHTEDEPSTSAAMLAARRTLQRLRLPSSSSDNEPSSNNQQMTIKSPSEQTTTRSSSNRHRHHSHHHHHHHHSHHHHHHQPTAAVAVAAAQDEQHNNNQPHSHSHSSSHHHHHNHQSHSHPHRANRSTRKRCSQEHCETITTTKTTSGGEQQTEDSLDSSTASSLSDDVSLAMRNTTARLKFKSTENLLHRLFVCIAGVADQLQTNFASDLRQILRSVFLMNMSSAQEDIDIPEKTKESELFEFRASENDVIQESAGSNQSIYSAEEVNPELDNVFNTNTGTNGARHSAGATMQRNNTIDLATVQSSNSGNSSSSNSSSSSSAARSHVARSRSLGDHDQASTSSSQQQQRELQLQLQQQQQQQAQMQQQLQRHRNNSVGSNSPSSASSTSSNSEHNSPVSTRSGSRRRLPSNTTTTLSTSIGTAATTPTGATTTGVTTTTTMSPPAWIPDGKAPRCMSCQTPFTVVRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRECFMREVRQSHSHGQSQSQIHSPTQQAGGRPQAASAS
What is the function of this protein?
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
What are the official names of this protein?
Lateral signaling target protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the lst-2 family.
Protein: ASNA_ENTDS
Sequence: MSLSPPNNLEHIITSQTLKWVFVGGKGGVGKTTTSCSLGVLIANRNPQKKVLIISTDPAHNTSDAFDIKFGAEPKAVPGVPNLSVMEVDVKDAMKGMFDGVEQGTNQNGEFGLLSEITGMVGMFKSVPGIDEAIAFSKIINQAQQMNYDLVLFDTAPTGHTLRFLSLPSVLRDMLEKVIKLQELFGPMMSQFGGIIGTNINFNELKPKMEDMLKTSEQIVKDFTNPNLTTFIPVLIPEFLPLYETERLIQELMNLNMDVNSIIVNQILPVNDCCDYCKNKRSVQAKYLGQIDVLYSDFHLIKINMQTNEVRGVPALCAFSKNFEAKH
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase ASNA1 homolog, Arsenical pump-driving ATPase homolog, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: EFTU_STAAM
Sequence: MAKEKFDRSKEHANIGTIGHVDHGKTTLTAAIATVLAKNGDSVAQSYDMIDNAPEEKERGITINTSHIEYQTDKRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSAADGPMPQTREHILLSRNVGVPALVVFLNKVDMVDDEELLELVEMEVRDLLSEYDFPGDDVPVIAGSALKALEGDAQYEEKILELMEAVDTYIPTPERDSDKPFMMPVEDVFSITGRGTVATGRVERGQIKVGEEVEIIGLHDTSKTTVTGVEMFRKLLDYAEAGDNIGALLRGVAREDVQRGQVLAAPGSITPHTEFKAEVYVLSKDEGGRHTPFFSNYRPQFYFRTTDVTGVVHLPEGTEMVMPGDNVEMTVELIAPIAIEDGTRFSIREGGRTVGSGVVTEIIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_SINMW
Sequence: MNEAATVLGTADIQEILKLLPHRYPFLLVDRIIEIDSDNSAIGIKNVTANEPHFTGHFPEKPIMPGVLLIEGMAQTAGAICARKTGGGSNLVYFMTIDNARFRKPVVPGDRVEFHVVKQKQRGNIWKFHCDAKVDGQLVAEADIGAMIVSKEDV
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRO5_ARATH
Sequence: MDYVRTQVEAVFDDSEQDGSTISESGSCDSSSDRSFADELGLMELLEGDKAHDLIYRNCKSGLGDQCQILSVLRNGFRNVGSRAKLKTFQVFQEAVQMKHGGDGGAKVKYGWCSVSKHELKTIFEYGFSEPLRNDGSFGRGLYLSPDNSPLDCLKDSASESEDGMRFLLLCRVLLGKSEIVPQGSTRSCPSSPEFDSGVDDLVSTKKYIVWSTHMNTHVLPEFLVCIKAPFNLTRSPKRLRSPWMAFPVLIKALSKFLPPSQILVIQKHYKDQQNRRITRSELIQRVRSITGDKLLVHIIKACGHKVQH
What is the function of this protein?
Probable inactive ADP-ribosyltransferase that may be involved in stress and developmental responses.
What are the official names of this protein?
Probable inactive poly [ADP-ribose] polymerase SRO5, Protein SIMILAR TO RCD ONE 5.
What are the subcellular locations of this protein?
Nucleus matrix. Note=Speckle-like pattern.
Protein: NHAA_PSYA2
Sequence: MAIHKIRAFFNLEASGGIVLALAAIAAMIIANTSLNTWYESFIHAPVAIQIGSFSIAKDAHHWINDGLMAVFFFLVGLELKREVLIGELSNVKQIILPAGAALGGMVMPAIVYLFFNYNEPEFWRGWAIPTATDIAFALGILSLLGNRVPNSLKVFLVSIAIFDDIGAIIIIALFYTNDLSLGSLAIAGLCLPFLYMLNRRNVTSITPYLLIGVIMWIAVLKSGIHATLAGVVLALFIPLFDRTDPEHSPLEELEHDLQNTVSYGILPLFAFANAGISLKGAGFGELFHSVPLGIAAGLFIGKQVGVMLMCWLIFKLGISTMPKGMNFKQIYGAALLCGVGFTMSLFIGGLAFAGETPLFDERLGIIMGSIVSGIAGYMMLKTTLKDEVNVTSVDLTRHS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: C450L_CYCRE
Sequence: MNEYLLPK
What are the official names of this protein?
Cytochrome P450-like protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RL30_SOLUE
Sequence: MEGMIRIKLYRSPICTPDKQKRVVKGLGLRKVNQIVERPDTPVFRGMVKKIPHLLMVVE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: CNFNB_XENLA
Sequence: MSYPVSAQPQGVQGYMSSNSSQWNSDVFDCCEDMGTCLCGTFVPCILACKVSKDYGECCCLPCLFGSVLAVRTGIRERYHIEGSICNDWVCLSFCAPCTLCQMARELKARN
What are the official names of this protein?
Cornifelin homolog B.
What is the protein family that this protein belongs to?
Belongs to the cornifelin family.
Protein: CAPSD_TYYVF
Sequence: MNTVVGRRIINGRRRPRRQTRRAQRPQPVVVVQTSRATQRRPRRRRRGNNRTGRTVPTRGAGSSETFVFSKDNLAGSSSGAITFGPSLSDCPAFSNGMLKAYHEYKISMVILEFVSEASSQNSGSIAYELDPHCKLNSLSSTINKFGITKPGKRAFTASYINGTEWHDVAEDQFRILYKGNGSSSIAGSFRITIKCQFHNPK
What is the function of this protein?
Major capsid protein that self-assembles to form an icosahedral capsid with a T=3 symmetry, about 23 nm in diameter, and consisting of 180 capsid proteins monomers.  Most of the 180 monomers are the major capsid protein, but a small percentage contain the minor capsid protein, which has a long C-terminal extension.
What are the official names of this protein?
Major capsid protein, Coat protein, CP.
What is the protein family that this protein belongs to?
Belongs to the luteoviruses capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: TRPC_STRSV
Sequence: MSKEFLPTILKQKEQEVAAMSYEELQPLRSTYSLYEYLKNHPQELQLIAEVKKASPSLGDINLGVDIVEQARTYERCGAAMISVLTDEIFFKGHLDYLREISSQVTIPTLNKDFIIDEKQIVRARNAGATVILLIVAALSEKRLQELYDFATGLGLEVLVETHNLAELETAHRIGAQIIGVNNRNLVTFETDINTSLQLSAHFKDDRVYVSESAIFSKEDAELVAPYFHAVLVGTALMQAENVAEKIKELKIDKG
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: NDEL1_RABIT
Sequence: MDGEDIPDFSSLKEETAYWKELSLKYKQTFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENSFPSPKAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVMNSNGTKFSRSGHTSFFDKGAVNGFDPAPPPPGLGSSRPLSAPGMLPLSV
What is the function of this protein?
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome.  May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome.  Also positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends.  Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome.  Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate.  Plays a role, together with DISC1, in the regulation of neurite outgrowth.  Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1.  Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.  Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).
What are the official names of this protein?
Nuclear distribution protein nudE-like 1, Protein Nudel.
What is the protein family that this protein belongs to?
Belongs to the nudE family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the interphase centrosome and the mitotic spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome. Localizes to the kinetochore in a CENPF- dependent manner (By similarity).
Protein: ATPD_BACC2
Sequence: MSNGIVAKRYAVALFKIAKEKHVLEMFEEELRLVQNVYVKNGELHSFLTQPNISKEQKKTFLANVFGSVSESILNTLYILIDNKRIDILPEIADEYVVLANEERNVADATVYSIRLLSEEEKLNIAEAFAKRTGKDAIRVKNVVDEDLLGGIKVRIGNRIYDGSLQGKLARIQRELMKNR
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL23_MYCLB
Sequence: MATIADSRDIILAPVISEKSYGLLDDNVYTFVVHPDSNKTQIKIAIEKIFSVKVASVNTSNRKGKCKRTRTGFGRRKNTKRAIVTLAPGSKSIDLFGTPA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: ATG1_ASPCL
Sequence: MSLGRYTRLDEIGRGSFATVYQGVHTKTGTYVAIKSVNLSKLNKKLKENLSSEIHILKGLYHPHIVALIDCQETSSHIHLVMEYCALGDLSLFIKRRDTLGDHRYTRDMIAKYPNPPGGALNEVVVRHFLKQLSSALKFLRDRNLIHRDIKPQNLLLCPSPSSYRSGAGSGAATVVPFKGCEDSFNPATGVDSLPLLKIADFGFARSLPATSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVVGKPPFRATNHVELLRKIEKGEDRIKFPEDNPASDAIKALIRALLKRNPVERLNFPEFFENEVITGPIPGLLADDQPSISRHRSVDPGTTEVPPRPDSRSGTSVPSGTRREREVNREDVYSPRSSPRNQKPSTPPTSTPMRRVGSTDRPPSAPKESEPPMAYPQRPNAVSHATAPGRQELLDRKATTTAIERQRSRNTYSEGSPRLDQPADKLKEEQERAAQDVAFERDYVVVEKRAVEVNAFADELAHSPRIQGGLSRAAQAGAISRRATVQGATPTLSSPQTTTGKAMQVFSGRSRADSTHHRQASYERRYGQSPTSATSAISKALNMASGRLFGMGFSPPLTITKGGRSPPLAYNPFPAYPTAHGSLMIIGDGAKSQVALDEDTKTVQVIEECATRSDVVYGFAEVKYKQLIPLAPSIQTDPSAKSNMSGVRDTAGSTDGDLTVDATVTLSEEALVLYVKALSLLAKSMDIAGVWWTRKNRGETFGDPVMSRADTTGALVGTRINNVVQWVRNRFNEVLEKAEFVRLKLIEGQKRLPPDHPSHPSNHSVTSSLGAGSTDIVVSSGVTAEKLMYDRALEMSRAAAINELTGEDLAGCEIAYVTAIRMLEAVLEDDEVPGLGPGKVDTSKDMYDGVPAEDRQVVVKLVSSIRGRLQALRKKLAILAKRAPTASVNV
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
What are the official names of this protein?
Serine/threonine-protein kinase atg1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: BRI1_ORYSJ
Sequence: MDSLWAAIAALFVAAAVVVRGAAAADDAQLLEEFRQAVPNQAALKGWSGGDGACRFPGAGCRNGRLTSLSLAGVPLNAEFRAVAATLLQLGSVEVLSLRGANVSGALSAAGGARCGSKLQALDLSGNAALRGSVADVAALASACGGLKTLNLSGDAVGAAKVGGGGGPGFAGLDSLDLSNNKITDDSDLRWMVDAGVGAVRWLDLALNRISGVPEFTNCSGLQYLDLSGNLIVGEVPGGALSDCRGLKVLNLSFNHLAGVFPPDIAGLTSLNALNLSNNNFSGELPGEAFAKLQQLTALSLSFNHFNGSIPDTVASLPELQQLDLSSNTFSGTIPSSLCQDPNSKLHLLYLQNNYLTGGIPDAVSNCTSLVSLDLSLNYINGSIPASLGDLGNLQDLILWQNELEGEIPASLSRIQGLEHLILDYNGLTGSIPPELAKCTKLNWISLASNRLSGPIPSWLGKLSYLAILKLSNNSFSGPIPPELGDCQSLVWLDLNSNQLNGSIPKELAKQSGKMNVGLIVGRPYVYLRNDELSSECRGKGSLLEFTSIRPDDLSRMPSKKLCNFTRMYVGSTEYTFNKNGSMIFLDLSYNQLDSAIPGELGDMFYLMIMNLGHNLLSGTIPSRLAEAKKLAVLDLSYNQLEGPIPNSFSALSLSEINLSNNQLNGTIPELGSLATFPKSQYENNTGLCGFPLPPCDHSSPRSSNDHQSHRRQASMASSIAMGLLFSLFCIIVIIIAIGSKRRRLKNEEASTSRDIYIDSRSHSATMNSDWRQNLSGTNLLSINLAAFEKPLQNLTLADLVEATNGFHIACQIGSGGFGDVYKAQLKDGKVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKAGEERLLVYDYMKFGSLEDVLHDRKKIGKKLNWEARRKIAVGAARGLAFLHHNCIPHIIHRDMKSSNVLIDEQLEARVSDFGMARLMSVVDTHLSVSTLAGTPGYVPPEYYQSFRCTTKGDVYSYGVVLLELLTGKPPTDSADFGEDNNLVGWVKQHTKLKITDVFDPELLKEDPSVELELLEHLKIACACLDDRPSRRPTMLKVMAMFKEIQAGSTVDSKTSSAAAGSIDEGGYGVLDMPLREAKEEKD
What is the function of this protein?
Receptor kinase involved brassinosteroid (BR) signal transduction.  Regulates, in response to BR binding, a signaling cascade involved in plant development, promotion of cell elongation and flowering (Probable).  Activates BR signaling by targeting and phosphorylating BSK3, a positive regulator of BR signaling (PubMed:26697897).  Forms at the plasma membrane a receptor complex with BAK1 which is activated in response to brassinolide.  Phosphorylates BAK1.  Phosphorylates REM4. 1, which reduces REM4. 1 binding affinity to BAK1 and allows the formation and subsequent activation of the BRI1-BAK1 receptor complex (PubMed:27424498).  Functions in various growth and developmental processes, such as internode elongation, bending of the lamina joint and skotomorphogenesis.  Functions in internode elongation by inducing the formation of the intercalary meristem and the longitudinal elongation of internode cells (PubMed:11006334).  Involved in organ development through the control of cell division and elongation.  Does not seem essential for organ pattern formation or organ initiation (PubMed:16407447).
What are the official names of this protein?
Brassinosteroid LRR receptor kinase BRI1, Protein BRASSINOSTEROID INSENSITIVE 1 homolog, OsBRI1, Protein DWARF 61.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.