PharMolix/UniProtQA huggingface dataset:
Protein: MYH10_RAT
Sequence: MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEKPPHIYAISESAYRCMLQDRKDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGTSFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVDRIVGLDQVTGMTETAFGSAYKTKKGMFRNVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEGEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLEEAKKKLLKDVEALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHIEGASLELSDDDTESKTSDVNETQPPQSE
What is the function of this protein?
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.  During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity).  Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
What are the official names of this protein?
Myosin-10, Cellular myosin heavy chain, type B, Myosin heavy chain 10, Myosin heavy chain, non-muscle IIb, Non-muscle myosin heavy chain B, NMMHC-B, Non-muscle myosin heavy chain IIb, NMMHC II-b, NMMHC-IIB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells.
Protein: NUON_THIDA
Sequence: MNMPLSLMQFAPALPEIFVLAMVSLILVIDAAVGDGKRYLAYGLSLVTLAGAAFLTVRDFSTLPVLALGGLFIDDPLSDVLKLFLYLTVAIVLVYSRDYLRVRGLYKGEFFVLALFALLGMMVMVSASHFLTLYLGLELLSLSLYAMVALQRDSSVATEAAMKYFVLGALASGMLLYGMSMVYGVTGSLALGDIAIVLQDGTDLRIPLVFGIVFVVAGLAFKLGAVPFHMWVPDVYHGAPTAMTLFVGSAPKIAAFAFVVRVLGQGLESQVSEWRDMLVILAVLSMAIGNIAAIAQSNLKRMFAYSTISHMGFMLLGVLAGSQNGYGAAMFYVLVYTLMTLGGFGMILLLSRAGFESDRLDDFKGLNRRSPWLAFVMLLLMFSMTGIPPTVGFYAKLAVLQAVVEIGYVWLAVAAVLFSLVGAFYYLRIVKLMYFDTPQDTAPIAPGIDARLLMSANGLAVLALGILPQPLMAVCVQAIGTSF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: P2C07_ORYSJ
Sequence: MAAHGGGGVEEDQAGSSSLCPPAAEAEAAAAAAAIARAARPPRPGRDKRLGVRHPLKHRRFRAGGKAAVAAGAREVGEATTVAEATATGPPKGSDEDDEARYICGGWTSDDGRMSCGYSSFRGRRANMEDFYDIKSSKVDDNQINLFGIFDGHGGSHAAEHLKKHLFENLLKHPSFITDTKSAISETYRKTDSDFLDAETNINREDGSTASTAIFVGNHIYVANVGDSRTVMSKAGKAIALSSDHKPNRKDERKRIENAGGVVTWSGTWRVGGVLAMSRAFGNRFLKRFVVAEPEVQEQEIDDDLEFLILASDGLWDVVSNEHAVAFVKAEEGPEAAARKLAEIAFARGSTDNITCIVVKFLHAKMAVDAASSSERS
What are the official names of this protein?
Probable protein phosphatase 2C 7, OsPP2C07.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: ASTD_AERHH
Sequence: MSQLVQFIDGQWLAGAGKPFESKDPAKNQVIWQGEAASAAQVEAAVKAARHAFYHWSDLALDYRLAIVRRYADLLGEHKEALALTIARETGKPLWETRTEVAAMQGKIAISIRAHDERTGTVENPMPGAKAFVRHKPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELTPMVAEAMLKIWQEAGLPKGVLNLVQGEVDTGKALAGNPDIDGLFFTGSSRTGHFLHQQFAGQPGKILALEMGGNNPLIVKDVSDIDGAVHAIVQSAFITSGQRCTCSRRLFVERSVQGDALVKRLVEVVGQIKVGLYDAAEQPFMGAMISEKAALGMVEAQANLQRLGGESLLTLTHLEAGTGFVSPGIIDVTAVSALPDEEYFGPLLQLIRYDDFDAAIDQGNATSFGLSAGLLGDSEADWQHFFKRIRAGIVNWNKPITGASSAAPFGGIGASGNHRASAYYAADYCAYPVASVEDSKAAMPDQLSPGLTF
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: TRMD_ENTFA
Sequence: MRIDVLTLFPRMFEGPMGESIIGKAREKQLLELNVSNFRDFSDNKHQTVDDYPYGGGAGMLLKVQPIYDNLKAIEEETNQQPKRVILLDPAGKPFNQKMAEEFSQEEHLVFICGHYEGYDERIRTMVTDEVSLGDYVLTGGELGAMVMIDATVRLLPDVLGNNLSAQTDSHSTGLLEHPQYTRPAIFNDMEVPAVLTNGNHKLIAEWQLKESLRRTFLRRPDMLESVEMTPEMLKLLEEIKQEEQK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPR2_ORYSJ
Sequence: MVHAPAKEAIPLLTPYKMGQLELSHRVVLAPLTRCRSYGHVPQPHAAVYYSQRATNGGLLIAEATVISPTAQGYPDTPGIYTQQQIEAWKPIVDAVHRKGALFFLQIWHVGRVSTTDFQPNGQAPISSTDKQITPDDSGMVYSKPRRLRTDEIPQIVDDFRRAARNAIESGFDGVEIHGAHGYLLDQFMKDSANDRTDEYGGNLENRCRFAVEVIDAVVAEVGAHRVGIRLSPFDNYMDCFDSNPVALGSYMVQQLNKHPGFLYCHMVEPGMAIVEGRRKITHGLLPFRKQFNGTFIAAGGYDREEGNKVVADGYADLVAYGRLFLANPDLPRRFELDAPLNRYDRSTFYTQDPVVGYTDYPFLEEIDEESTTTYA
What is the function of this protein?
Putative oxophytodienoate reductase that may be involved in the biosynthesis or metabolism of oxylipin signaling molecules.
What are the official names of this protein?
Putative 12-oxophytodienoate reductase 2, OPDA-reductase 2, OsOPR2.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Protein: ST_POVBK
Sequence: MDKVLNREESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPDFGTWSSSEVCADFPLCPDTLYCKEWPICSKKPSVHCPCMLCQLRLRHLNRKFLRKEPLVWIDCYCIDCFTQWFGLDLTEETLQWWVQIIGETPFRDLKL
What is the function of this protein?
Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle.  Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit.  Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters.  Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation.  May establish and maintain high levels of viral genomes during persistent infection in cell culture.
What are the official names of this protein?
Small t antigen, ST, ST-AG.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: Y479_MYCPA
Sequence: MAGNSRRRGAVRKAGTKKGPTVGSGGQRRRGLEGRGPTPPAHLRPNHPAAKRAQSPPRRPAKRTEETETVLGRNPVLECLRAGVPATALYVALGTEADERLTESVSRAADSGISILEVPRADLDRMTGNHLHQGIALQVPPYIYAHPDDLLEAAAGSLPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQRRSASVTAVAWRTSAGAAARIPVARATNLTRTLQDWADRGLRVIGLDAGGDTMLDDLDGSDPLVVVVGSEGKGLSRLVRQNCDEVVSIPMAGSAESLNASVAAGVVLAEISRQRRG
What are the official names of this protein?
Uncharacterized tRNA/rRNA methyltransferase MAP_0479.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: XYLA_BRUC2
Sequence: MSTGFFGDIQKVRYEGPESDNPLAFRHYNADEIVLGKRMEDHLRFAVAYWHSFAWEGGDPFGGRPFDRPWFSNEIDAAKLKADVAFEFFSLLGAPYYCFHDADVRPEGRNFAENTRYLNEIVDIFEKKQAETGMKLLWGTANLFSNRRYMAGAATNPDPDVFAFAAATVKTCIDATKRLGGENYVLWGGREGYETLLNTDLSRELDHMGRFLSLVVEYKHKIGFKGTILIEPKPQEPTKHQYDYDVATVYGFLKRYGLENEVKVNIEQGHAILAGHSFEHELALARTLGIFGSIDMNRNDYQSGWDTDQFPNNVPEMALAYYQVLLAGGFTTGGTNFDAKLRRQSLDPQDLLIGHIGGMDCCARGLKAAARMLEDGALSKPLDERYAGWNGEFGKRLLSGLSLDQIAGEVEAKDINPQPKSGRQEYLENIVNRYV
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GHR_CANLF
Sequence: MDLWQLLLTLAVAGSGSAFSGSEATPTILGSASQSLQRVNPGLGTNSSEKPKFTKCRSPELETFSCHWTDGVRHGLKNAGSVQLFYIRRSTQEWTQEWKECPDYVSAGENSCYFNSSYTSIWIPYCIKLTSNGGTVDQKCFSVEEIVQPDPPIGLNWTLLNISLTGIHADIQVRWEPPPNADVQKGWIVLKYELQYKEVNESQWKMMDPVSATSVPVYSLRLDKEYEVRVRSRQRNSEKYGEFSEALYVTLPQMSPFACEEDFQFPWFLIIIFGIFGLTMILFLFIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDNYKPEFYNDDSWVEFIELDIDDLDEKTEGSDTDRLLSNDHEKSLNILGAKDDDSGRTSCYEPDILETDFNASDVCDGTSEVAQPQRLKGEVDLLCLDQKNQNNSPSTDTTPTTQQPSIILAKENKPRPLLISGTESTQQAAHTQLSNPSSLANIDFYAQVSDITLAGSVVLSPGQKNKAGISPCDMPPEVASLCQANFIMDNAYFCEADAKKCITVAPHVEAESRVEPSFNQEDIYITTESLTTTAGQSGTTERAVSSEMPVPDYTSIHIIQSPRGLVLNATALPLPDKEFLSSCGYVSTDQLNKIMP
What is the function of this protein?
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
What are the official names of this protein?
Growth hormone receptor, GH receptor, Somatotropin receptor.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. SUBCELLULAR LOCATION: [Growth hormone-binding protein]: Secreted. Note=Complexed to a substantial fraction of circulating GH.
Protein: EGFL7_HUMAN
Sequence: MRGSQEVLLMWLLVLAVGGTEHAYRPGRRVCAVRAHGDPVSESFVQRVYQPFLTTCDGHRACSTYRTIYRTAYRRSPGLAPARPRYACCPGWKRTSGLPGACGAAICQPPCRNGGSCVQPGRCRCPAGWRGDTCQSDVDECSARRGGCPQRCVNTAGSYWCQCWEGHSLSADGTLCVPKGGPPRVAPNPTGVDSAMKEEVQRLQSRVDLLEEKLQLVLAPLHSLASQALEHGLPDPGSLLVHSFQQLGRIDSLSEQISFLEEQLGSCSCKKDS
What is the function of this protein?
Regulates vascular tubulogenesis in vivo.  Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.
What are the official names of this protein?
Epidermal growth factor-like protein 7, EGF-like protein 7, Multiple epidermal growth factor-like domains protein 7, Multiple EGF-like domains protein 7, NOTCH4-like protein, Vascular endothelial statin, VE-statin, Zneu1.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: TOP1_FERIS
Sequence: MAKSKVVEKDKKNELDNQSADIELKGQSKNEESKGGKKKVIIVESPAKAKTIERILGNDYQVISSKGHIRDLPQKQFGVDLNSLKLDFEIIPGKESVVEQIKKMTSGKEVLLPSDQDREGEAIAWHLSTILGVKGKNIITFTEITERAIKEAVKNPREIDMNKVNAQLARRVLDRIVGYMISPLLWRIIKDARSAGRVQSAALKIICERERERYRFVPQKYFKVWIDIAGLKAYLTKVDGKKIKPTDITEEISKDVLQKVKSVRLVDIDVKEVRKNPPAPFITSTLQQDAASKLGFPVSKTMKIAQELYEGVDTKEGHTAFITYMRTDSTRVSDVAKEAAEKFILKNFGREYLNESSEVASKKGSKTKGKVQDAHECIRPVDVNITPEKAKELLDKDHHKLYELIWKRFIASQMSSAIYKQYSYDFESGKYVFEASIRERIFDGFEKVYTIDNEPSEKHKELKVDQEYLVEPKSAEAQTTPPDRYTEASLVKTLEMEGIGRPSTYATIIQTLLDRGYVVKKRKTLIPTILGFVVNHYLEQRFPDIVDKGFTAEMEKELDEVENGKKDWKEVVKSFLKEFNKDLERAKNEFFAIDFDTDITCEDCSGNYKLKVGKYGLYLHCPNCKTNKALKSDVFGVIDGNKLYVLEEQESQEENGEKNSVQSEESSANSGNRKFYRKRRTSGSKKSSTKSASSKAKKK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: ATPG_BRUSU
Sequence: MPSLKDLRNRIASVKATQKITKAMQMVAAAKLRRAQEAAEAARPYSQRMGAVLANIAQNVSGEDAPALMVGTGKDDVHLLVVCTAERGLCGGFNSQIARLARDHARKLLAEGKTVKIITVGKKGADILRREFSALLHDHVDLREVKQLAFVHADQIGHKIIKLFEEGAFDVCTLFYSEFKSVISQVPTAQQLIPASADNEAEMETAGDAIYEYEPDPAAILSTLIPRNISVQIFRALLENVAGEMGAKMSAMDNATRNAGDMINKLSITYNRQRQAQITKELIEIISGAEAL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ADDA_CLOBH
Sequence: MSGTKWTDEQRQAIFTKDCNLLVAAGAGAGKTAVLVQRIIEKILDKGEPIDIDKLLVVTFTNAAAAEMRERIGDAISKGLDEDPESKVLRKQLTLLNKSNIMTIHSFCLQVIKNNFHTMEIDPNFRICDETEGILMKQEAIDELFDELYEIENEDFINLVESYASRKDTRLQEVVLELHRFAKSAPFSYDWLLNMAEEFNVGEEFNFEETPWADMIMEDMKVLLHGFKNMLQQSIDVILNSEGIDYYYEPFKMDLSFINSLLEKSSFKEFRGEIIAYDFPKLPLKRNKDADKEAKERVKKLRDKVKKKIVELKNILDSYENEFIKKEFIFLYPSMKALSNLVILFDKKYEAKKRERDLIDFNDIEHLCLSILTDKNSEGHIIPSDIALDYRKKFAEVLIDEYQDSNLVQEVIMSMVSRVKGYWSFYNGQLMFNEEEINLEEPQICLDIPNRFMVGDVKQSIYRFRQAKPEIFLDKYNEYSEEEGTKNRKVKLFKNFRSRKEVINGVNYLFKQIMSKTIGELDYTEEEALKVGASYGEEVKGEPIELCLMDKKYEISEEVLKEYNVDEEEALDNIQLEGRLVAKKIQKLVGNNLEGGLKVFDKKLGEYRNLQYRDIVILMRATSNWAPIFVEELAKEGIPVFADTNSGYFDTAEIKTMISLLQIIDNPLQDIPLLSVLRSPIASFTDDELIDIRMVNKNITFYECMEIIYRLYKNEKLDSYYSFYIEDENKINKIIKDMNEKLKNKICSFIEKLKLWREKSIHIDIDEFIWFLYVETGYYGYAGALQAGEQRQANLRILFQRAKQYAKTSYKGLFNFINFINKLKFSSGDMGSAKILGENENVVRIMSIHKSKGLEFPVVILSGTGKNFNMTDLNKNILFHRDLGYGPDYVDTERRIAYPSLVKNIIKNKIRLETLSEEMRILYVALTRAREKLIITGLINNMDKTVEDWLNLSEDKNKVPEYAVMSGKTYLDWIGPALIKHKDAVSFREELKMTSELSNIVDDKSKWKIELWNKRELLKEKVEEDEVEISEKIKETLMNLEESNYKEEIYKRLSFKYKYDNASSIPTKLSVSDVKKQFILDEKENTEELFKKLELRKPMFMEEKKKISPSERGTIIHLFMQHLDLKKAENEEDIKEQINRLIEREFITYEQSKVINPYKILKFCRGELGKRILNSNNVNKEMPFSIEIPALEIYKELDKEIYKDEKLIIQGVIDCYFEEEDGLVLLDYKTDYVNDIEEIKNRYEIQIKYYEEALNRITGKNVKDKYLYLFSVDNYIKID
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: RPOE_STRPG
Sequence: MKLDVFAGQEKSELSMIEVARAILEERGRDNEMYFSDLVNEIQNYLGKSDAGIRHALPFFYTDLNTDGSFIPLGENKWGLRSWYAIDEIDEEIITLEEDEDGAQKRKKKRVNAFMDGDEDAIDYRDDDPEDEDFTEESAEVEYDEEDPDDEKSEVESYDSELNEIIPEDDFEEVDINEEDEEDEEDEEPVL
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: TILS_AGRFC
Sequence: MPVDARTPNEKTVAPLAAASAFVESLRKPTHILVAISGGSDSTGLLLALQEAKAADDDGLRLSAVTVDHALRPESADEARKVAMLCAELGIPHTTRRWDGPKPASGLSEASRLARYRLIADVAREIGADLVVSGHTIGDQRETVAMRAARSGGSDNLGLSGMADAVLYDAHLWIMRPFLACERQVIRDYVSSRSRHWLDDPSNENIRYERVRVRQTLPHSPIALDDSTAVRRQMLSERTAVFLRERAQVFHAALARLADDDVNPDLPEFRHGLAALIAALGGRSYFPAASSMERVLRFLKTGETGRMTVGRVLLDRRRDGLYIFREQRNLPELQIESSGQAVWDDRFLVKNGSDFPINVAAGRVGTAAQAAALFPSAPSGVVKPAMAGLPQIAAAAEGWVSTPEVAITPRLAPFDLFLPRFDLELANAIANLFGRPAYPQPPV
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A85C_MYCAV
Sequence: MSFIEKVRKLRGAAATMPRRLAIAAVGASLLSGVAVAAGGSPVAGAFSKPGLPVEYLEVPSPSMGRNIKVQFQGGGPHAVYLLDGLRAQDDYNGWDINTPAFEEFYQSGLSVIMPVGGQSSFYSNWYQPSSGNGQNYTYKWETFLTQEMPLWMQSNKQVSPAGNAAVGLSMSGGSALILAAYYPQQFPYAASLSGFLNPSEGWWPTLIGLAMNDSGGYNANSMWGPSTDPAWKRNDPMVQIPRLVANNTRIWVYCGNGTPSDLGGDNVPAKFLEGLTLRTNEQFQNNYAAAGGRNGVFNFPANGTHSWPYWNQQLMAMKPDMQQVLLSGNTTAAPAQPAQPAQPAQPAQPAT
What is the function of this protein?
The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M. tuberculosis to murine alveolar macrophages (AMs).  They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor).  They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM (By similarity).
What are the official names of this protein?
Diacylglycerol acyltransferase/mycolyltransferase Ag85C, DGAT, Acyl-CoA:diacylglycerol acyltransferase, Antigen 85 complex C, 85C, Ag85C, Fibronectin-binding protein C, Fbps C.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial A85 antigen family.
What are the subcellular locations of this protein?
Secreted.
Protein: GSA_BORA1
Sequence: MSRNAELFERASRSIPGGVNSPVRAFRSVGGTPRFIKRALGPHIWDADGKQYIDYLGSWGPAILGHAHPEVVRAVQDAATGGLSFGAPTEAEVELAELLIQRLPSMEQVRLVSSGTEATMTAIRLARGATGRNKIIKFEGCYHGHSDSLLVKAGSGLLTLGNPSSAGVPPEFVAHTITLDYNNLPAVQTAFAEHGRDIACVIVEPVAGNMNLIKPAAGFLEGLRELCTRHGSVLIFDEVMTGFRVGPQGVQGLTGITPDLTTLAKVIGGGMPVGAFGGRADLMRHIAPLGSVYQAGTLSGNPVAVAAGLATLRLIGQPGFYEDLSARTQRLALGLTERAHAAGVTFSADAIGGMFGLYFRDKVPTSFAEVQTSNTEAFKRFFHAMLDRGVHFAPSAFEAGFVSAAHDDATLQATLDHAEAAFALLKA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHLEP_MYCTU
Sequence: MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILPVGALSAIARNLRVSVVLVGTLLSWYALVAAVTTVPLVRWTAHWPRRRALVVSLVCLTVSQLVSALAPNFAVLAAGRVLCAVTHGLLWAVIAPIATRLVPPSHAGRATTSIYIGTSLALVVGSPLTAAMSLMWGWRLAAVCVTGAAAAVALAARLALPEMVLRADQLEHVGRRARHHRNPRLVKVSVLTMIAVTGHFVSYTYIVVIIRDVVGVRGPNLAWLLAAYGVAGLVSVPLVARPLDRWPKGAVIVGMTGLTAAFTLLTALAFGERHTAATALLGTGAIVLWGALATAVSPMLQSAAMRSGGDDPDGASGLYVTAFQIGIMAGALLGGLLYERSLAMMLTASAGLMGVALFGMTVSQHLFENPTLSPGDG
What is the function of this protein?
Active efflux pump that plays an important role in chloramphenicol resistance (PubMed:31054279).  Overexpression causes pyrazinamide resistance (PubMed:28584158).
What are the official names of this protein?
Chloramphenicol efflux pump Rv0191.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1951_BACAC
Sequence: MNRLSTKLVVAIGIGSALYGILGLWGFSIAPNTFIKPALAILTVFGALFGPVAGLLIGLIGHTVTDTIAGWSIWWGWVISSGIIGFTMGFIQKRVGFSVKNGTYNKGDISYLAITGLIGIVIAIIFAGAFDIIVMGEPFDKIVIQVLGATIADVIVFLVLGLPITIGLAKSNKKHTHLKIEK
What are the official names of this protein?
UPF0397 protein BAMEG_1951.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ANR53_MACFA
Sequence: MASAGSTARRAGSGSWHSERGEGRGARPQPTPHGSMQRANKVSLKATWTDAESKQPRPSEESDQTTIDQTAIRSYYQLFAAAVGNVEWLRFCLNQSLREIPTDYKGFTAIHFAAQRGKLACLQVLVEEYKFPVNLLTNNSQTPLHLVIHKDNTTVALPCIYYLLEKGAALNAQTCNGCTPLHLAVREGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFACEMRKMKTLKSQLALMEYNYLIEYQKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSKTPEQRGSQCSSSFHPSVEARLQCIPQPTEMPKPIYRKSTIKRPTMWNVSNNPARPPTTKISHSQGIRLGVHPDPSPEHDFSSFLEVRPDRHGGAWLHTVDGHWVAPVPRLPFEVLLRMLYPHVRPYRMKVPQGFYPISMREVPRKRHLGDDTFWTDTLAMNLRDTFDEAFLAAVRSHQGLPALPSPQINP
What is the function of this protein?
Required for normal progression through mitosis.  Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.
What are the official names of this protein?
Ankyrin repeat domain-containing protein 53.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at the spindle around the centrosome at prophase and prometaphase and at the spindle poles at metaphase and anaphase.
Protein: DNAK_METS4
Sequence: MGKVIGIDLGTTNSCVAVMEGTQPKVIENAEGARTTPSIVAFTDEGERLVGQPAKRQAVTNPSRTFFAIKRLIGRTYDDPMTQKDKGLVPYHIVRAGNGDAWVEADGKQFSPSQISAFTLQKMKETAESYLGQPVTQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKKKSGVIAVYDLGGGTFDVSILEIGDGVFEVKSTNGDTFLGGEDFDNRIVEYLAAEFKREQGIDLTRDKLALQRLKEAAEKAKIELSSATQTEINLPYITADASGPKHLALKLSRAKFESLVDDLIQRTIEPCRKALKDAGVAASEIDEVVLVGGMTRMPKIQDVVKTFFGKEPHKGVNPDEVVAIGAAVQAGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIDRNTTIPTKKSQVFSTAEDNQNAVTIRVFQGEREMAADNKLLGQFDLVGIPPAPRGVPQIEVTFDIDANGIVNVTAKDKATGKEHQIRIQASGGLSDTEIQRMVQEAEANAAEDKKRRELVEVKNQGESLVHATEKSVKEYGDKVSESDRAGISTAIDALRQALAGEDVETIKARTTDLMQASMKLGEAMYAAQAGGGEAASAGAEDPQAKKDDVIDADFQEVDDKDHKKRA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.