PharMolix/UniProtQA huggingface dataset:
Protein: IFNG_CHICK
Sequence: MTCQTYNLFVLSVIMIYYGHTASSLNLVQLQDDIDKLKADFNSSHSDVADGGPIIVEKLKNWTERNEKRIILSQIVSMYLEMLENTDKSKPHIKHISEELYTLKNNLPDGVKKVKDIMDLAKLPMNDLRIQRKAANELFSILQKLVDPPSFKRKRSQSQRRCNC
What is the function of this protein?
Produced by lymphocytes activated by specific antigens or mitogens.  IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions.  It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: SURA_ALIF1
Sequence: MKNWKFPLISTLLLLLTINVHAAPVELDRVVAIVDEGVVLQSDIDTSLKTVKINAQEKGQPLPDEAVLREQVLEKLIVDTIQSQQAEKMGIRIDDTRLEAALNDIAKENNMTLAQLQQKTAAQGLPYANFREQIRKEIAASEARNAQVRRRINILPQEVESLAQLLAEETQATVQYKISHIQLRVEDGATQADKEALEKQAEDLTERLKQGADFATMAYTYSKGPKALQGGDWGWMRKEEMPTIFADQITGQGKNSIIGPFRSGVGFHILKIDDVKGLETVAVTEVNARHILIKTSVIMSDEGAQRLLNTIIDDIKSGKETFADMAQRYSQDPGSAANDGELGFQTPDLYVPEFKHQVETLPVGQISAPFKTVHGWHIAEVLERRQVDRTDAAMKNKAYRILLNRKFNEEAGAWLQEIRASAYVEILQDDDGEDDNE
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: PRIS_METBF
Sequence: MDNRTARFLKTRFQKYYKNAEIGLPDHLPNREWAFIFFDSMPDKMMHRHKAFGSPGEALDYLYGMAPAHVYNSTAYYEYPDARKMNEKNWLGAELIFDLDADHLPDAPKNYADMLELVKKETFKLMDFLLEDFGFSEQEIELVFSGGRGYHFHVRSPKVLKLGSAERREIVNYLSGRDLDFKYFFREVAMDGEFGTGSKTFKGMKNVPFKCTLVGYDSGWGRRIALYLTDYMKAECGKRYKKDMFPELRRYEKVGDTTIKKLISLTNSENGLKDILEKGRLDFDVRNFKDIAAYFMRESVEDFLHRFGTSVDEPVTADIKRLIRVPGSLHGGSGMLVKKLALSELEKFDPLTDAVVFGERPVKVTVLKPFSVQLKGKDLRVEEGIQEVPEYAAVYLICRGVAEYGHRRNQPGPV
What is the function of this protein?
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  The small subunit contains the primase catalytic core and has DNA synthesis activity on its own.  Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase small subunit PriS.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: MNMA_BAUCH
Sequence: MNIINKKVIVGMSGGVDSSVSALLLLQQGYTVEGLFMKNWEEDDHEQYCTVAKDLADAQAVCNQLGIILHKVNFAAEYWDNVFEYFLAEYQVGRTPNPDILCNKNIKFKVFLDFATQNLGADYIATGHYVIRKDINGKSRLLRGLDNQKDQSYFLYTIGYQQMARCFFPLGKLNKLRVREIAAKQGLVTASKKDSTGICFIGKRKLSDLLSRYISAKPGAIITVDNEYIGYHQGLMYYTLGQRKKLGIGGTKNGSQDPWYVVDKDINHNLLIIAQGHNHPRLMSNGLIASKLYWVDRTTLSTPLRCTVKTRYRQSDIGCLIKPIANNQLQVDFDYPVAAVTPGQSAVFYLAEQCIGGGTIEIRKPLGS
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRC_DROPS
Sequence: MMSSRTDTDGSSIRFSDHTLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLTESQRQEKRLQHAQKETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKMYYSFQDQVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIIKFCCEADRRLGSQRGLEDLKSVPFFRGVDWEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQGGEIAKDWVFINYTYKRFEVRNLE
What is the function of this protein?
Serine/threonine-protein kinase involved in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites.  Together with fry, maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons.  Reduces neurite outgrowth by phosphorylating pav/pavarotti, thereby inhibiting its function in microtubule-microtubule sliding.
What are the official names of this protein?
Serine/threonine-protein kinase tricornered, NDR protein kinase, Serine/threonine-protein kinase 38-like, Serine/threonine-protein kinase tricorner.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Trc colocalizes with Mob1 to the cell periphery in wing cells and wing hairs.
Protein: LKHA4_HUMAN
Sequence: MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
What is the function of this protein?
Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities.  Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921).  Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029).  In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641).  Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090).
What are the official names of this protein?
Leukotriene A-4 hydrolase, LTA-4 hydrolase, Leukotriene A(4) hydrolase, Tripeptide aminopeptidase LTA4H.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFXN2_MOUSE
Sequence: MEGDLSGFNIDAPRWDQCTFLGRVKHFFNITDPRTVFASEQELDWAKAVVEKSRMGLVPPGTQMEQLLYAKKLYDSAFHPDTGEKMNVIGRMSFQVPGGMLITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVATAVGMNMWTKRAPPLVGRWVPFAAVAAANCVNIPMMRQQELIQGICVKDRNQNELGHSQRAAAVGIAQVVISRITMAAPGMILLPVIMERLERLHLMKKVKVMHAPLQVLLCGCFLLFMVPVACGLFPQECELSVSYLEPELRDTIKAKYGEQVLFVYFNKGL
What is the function of this protein?
Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria (By similarity).  Involved in mitochondrial iron homeostasis by regulating heme biosynthesis (By similarity).
What are the official names of this protein?
Sideroflexin-2.
What is the protein family that this protein belongs to?
Belongs to the sideroflexin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: PANB_ECOBW
Sequence: MKPTTISLLQKYKQEKKRFATITAYDYSFAKLFADEGLNVMLVGDSLGMTVQGHDSTLPVTVADIAYHTAAVRRGAPNCLLLADLPFMAYATPEQAFENAATVMRAGANMVKIEGGEWLVETVQMLTERAVPVCGHLGLTPQSVNIFGGYKVQGRGDEAGDQLLSDALALEAAGAQLLVLECVPVELAKRITEALAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYMAEVESGVYPGEEHSFH
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RACC_ENTH1
Sequence: MSEKPTSIKLVVVGDGAVGKTCLLISYSIRKFPEDYIPTVFDNYVVSLTAGTRQIQLALWDTAGQEEYDQLRPLSYSSASIFLICFSVTSSVSYDNVITKWHPEVIHFAPKVPIILVGTKLDTRNDPAIVKRLTEQGMTVINTAKGEELKNRIKAVKYIECSAKTSENLKTVFDEAVKTVLMNKPQQRSKCALL
What is the function of this protein?
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states.
What are the official names of this protein?
Rho-related protein racC, EhRacC.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
Protein: METK_CERS4
Sequence: MSRMNYVFTSESVSEGHPDKLCDRVSDAVLDTFLAEEPTARVACETFATTGRVVVGGEVGLSDPQKLDEFMERVDGIVRDCVKDIGYEQQEFHWRTIEVQNFLHRQSAHIAQGVDKDGAGDQGIMFGYACRETPELMPAPIQYSHAILRRLAEVRKSGQEPDLRPDAKSQLSLRYENGKPVEVRSIVLSTQHAHEEQTSDDIRAIVEPYIREVLPEGWITEATEWWVNPTGTFVIGGPDGDAGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYAARYLAKNVVAAGLAERCTLQVSYAIGVAKPLSIYVDTHGTGQVDAAQIEKAVADCMDLTPRGIREHLNLCRPIYARTSAYGHFGRAPEADGGFSWERTDLTDALLKAV
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_KLEAE
Sequence: MRVVILGSGVFGVASAWYLSQAGHDVTVIDRQPGPAEETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAIGLDGTSFQLKWMWQMLRNCDTRHYMENKGRMVRLAEYSRDCLKALRDTTGIQYEGRQGGTLQLFRTAKQYENATRDIAVLEDAGVPYQLLEAKRLAEVEPALAEVSHKLTGGLRLPNDETGDCQLFTTRLAAMADQAGVTFRFNTAVDALLHEGDRIAGVKCGMRIIKGDAYVMAFGSYSTAMLKGLVDIPVYPLKGYSLTIPIAQEDGAPVSTILDVTYTIAITRFDQRIRVGGMAEIVGFNKTLLQPRRETLEMVVRDLFPRGGHVEQATFWTGLRPMTPDGTPVVGRTAYKNLWLNTGHGTLGWTMACGSGQLISDLISGRTPAIPYDDLAVARYSPGFTPARPQHLHGAHN
What is the function of this protein?
Catalyzes the oxidative deamination of D-amino acids.  Participates in the utilization of alanine as the sole source of carbon and nitrogen for growth.
What are the official names of this protein?
D-amino acid dehydrogenase, D-alanine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: CUTI2_ASPFN
Sequence: MNLRLLTLALAAVAAASPVDIQERQLSGGNELRDGSCKPITFIFARASTEPGLLGISTGPAVCNGLKMAKAGQVACQGVGPKYTADLASNALPENTSPAAIQEAQDLFQQAVTKCPDTQIVAGGYSQGTAVMDDSIKRLPDNVKEKIKGVVLFGYTRNAQEHGQIANFPKDKVKVYCAVGDMVCDGTLIVGPAHFTYLGNTGEATQFLLGKLSASSSSSSSSGSSDTSSASTSAAADSSSSSSSSSSPFGNLGNLFGGL
What is the function of this protein?
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (By similarity).  Degrades cutin, a macromolecule that forms the structure of the plant cuticle (By similarity).
What are the official names of this protein?
Probable cutinase 2, Cutin hydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: INSL6_MOUSE
Sequence: MKQLCCSCLLWLGLLLTPFSREEEEESRPRKLCGRHLLIEVIKLCGQSDWSRFEMEEQSPMTQFFPHYSRKGKAFNPHPSSSAWRRFTNPVPAGVSQKKGTHTWEPQSLPDYQFEKTELLPKARVFSYHSGKPYVKSVQLQKKSTNKMNTFRSLFWGNHSQRKRRGFADKCCVIGCTKEEMAVACLPFVDF
What is the function of this protein?
May have a role in sperm development and fertilization.
What are the official names of this protein?
Insulin-like peptide INSL6, Insulin-like peptide 6.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVD_PSEP1
Sequence: MPDYRSKTSTQGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADAVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLASHGLDLVDAMVIAADSTASDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHSDREQLFLTAGRTIVELCKRYYGENDESVLPRSIANFKAFENAMMLDIAMGGSTNTILHLLAAAQEGEVAFDLRDIDRLSRKVPQLCKVAPNIQNYHMEDVHRAGGIFSILGSLARGGLLHTDLPTVHSRSMEEAIAKWDITQTDDEAVHTFFKAGPAGIPTQTAFSQSTRWETLDDDRENGCIRSFEHAYSQEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGTAKIFESQDSAVRGILADEVKAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRDGDKVLIDIPNRSINLLVSDEELAERRVEQDKKGWKPAEVRPRKVTTALKAYALLATSADKGAVRNKAMLEGL
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: ODP2_MYCPN
Sequence: MANEFKFTDVGEGLHEGKVTEILKKVGDTIKVDEALFVVETDKVTTELPSPYAGVITAITTNVGDVVHIGQVMAVIDDGAGAAAPAAPQPVSAPAPAPTPTFTPTPAPVTTEPVVEEAGASVVGEIKVSNSVFPIFGVQPSAPQPTPAPVVQPTSAPTPTPAPASAAAPSGEETIAITTMRKAIAEAMVKSHENIPATILTFYVNATKLKQYRESVNGLALSKYNMKISFFAFFVKAIVNALKKFPVFNGRYDKERNLIVLNKDVNVGIAVDTPDGLIVPNIKQAQTKSVVDIAKDIVDLANRARSKQIKLPDLSKGTISVTNFGSLGAAFGTPIIKHPEMCIVATGNMEERVVRAEGGVAVHTILPLTIAADHRWVDGADVGRFGKEIAKQIEELIDLEVA
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: PEPT_YERPS
Sequence: MDKLLDRFFNYVSFDTQAKANVKSVPSTQGQRKLAQALQQELLTLGFSHVTLSDHGCVMATLPANVSWPVPTIGFIAHLDTSPDFSGKNVNPQIVENYRGGDIALGIGDEVLSPVMFPVLHQLLGHTLITTDGKTLLGADDKAGIAEIITAMVRLKHRNVPHGDIRIAFTPDEEVGKGAQFFNVAEFDAQWAYTVDGGGIGELEFENFNAASVAIKIVGNNVHPGSAKGVMVNALSLATRYHQELPVDETPECTEGYDGFYHLQSIKGTVERAEMHYIVRDFNRDSFEARKKNMVDIAKRVGKGLHRDCYIEIVIDDSYYNMREQIIKHPHIIELAQQAMLDCDITPIMKPIRGGTDGAQLSFKGLPCPNIFTGGYNYHGKHEFITLEGMEKAVAVIMRISELTAKRAKES
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_POLAQ
Sequence: MAFGKKPDFKKKPAQNPLFKRKRYCRFTVAGVEQIDYKDVDTLKDFIGENAKITPARLTGTKAKYQRQLDTAIKRARYLALLPFSDQHKK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: ASSY_SHEB2
Sequence: MSIEIKNTGVKKVVLAYSGGLDTSAIIPWLKENYDNCEIIAFCADVGQGEEELVGLTEKALASGASECHIVDLKEEFVKEYIYPTIASGAIYEGTYLLGTSMARPIIAKAQVEVARKVGADALCHGCTGKGNDQVRFEGCFAALAPDLKVIAPWREWTMQSREDLLAYLAERDIKTSASATKIYSRDANAFHISHEGGELEDPWNEPSKGVWTLTADPEDAPNKPEYVSLEVEHGRITKVNGEALTPYAALMTLNAIAAPHGVGRIDITENRLVGMKSRGCYETPGGTVMFAALRAIEELVLDKTSRNWREQVAAQMAHLVYDGRWFTPLCKSLLAASESLAESVNGEVVVKLYKGQATAVKKRSPNSLYSEAFATFGEDQVYDQKHAEGFIRLYSLASRIRALNANDVKSK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_ECO55
Sequence: MTEKKYIVALDQGTTSSRAVVMDHDANIISVSQREFEQIYPKPGWVEHDPMEIWATQSSTLVEVLAKADISSDQIAAIGITNQRETTIVWEKETGKPIYNAIVWQCRRTAEICEHLKRDGLEDYIRSNTGLVIDPYFSGTKVKWILDHVEGSRERARRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHTLDWDDKMLEVLDIPREMLPEVRRSSEVYGQTNIGGKGGTRIPISGIAGDQQAALFGQLCVKEGMAKNTYGTGCFMLMNTGEKAVKSENGLLTTIACGPTGEVNYALEGAVFMAGASIQWLRDEMKLINDAYDSEYFATKVQNTNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNANHIIRATLESIAYQTRDVLEAMQADSGIRLHALRVDGGAVANNFLMQFQSDILGTRVERPEVREVTALGAAYLAGLAVGFWQNLDELQEKAVIEREFRPGIETTERNYRYAGWKKAVKRAMAWEEHDE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: SNX1_PONAB
Sequence: MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKRATSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKMPAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYIQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLPKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
What is the function of this protein?
Involved in several stages of intracellular trafficking.  Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC).  Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity.  Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1).  Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi.  Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R.  Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN.  Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity).
What are the official names of this protein?
Sorting nexin-1.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans- Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles. Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner.
Protein: AQDC_MYCA9
Sequence: MITTKTVNGVQIAFDDQGHEPGPVFVTLSGWAHDLRAYDGMLPYLRAAQRTVRVCWRGHGPDRNLVGDFGIDEMAADTIGLLDALEVDSFVPIAHAHGGWAALEIADRLGAQRVPAVMILDLIMTPAPREFVAALHGIQDPERWKEGRDGLVQSWLAGTTNQAVLDHVRYDSGGHGFDMWARAGRVIDEAYRTWGSPMRRMEALAEPCAIRHVFSHPKIGEYDALHDDFAARHPWFSYRRLGGETHFPGIELPQQVAAEAIDLLAGARI
What is the function of this protein?
Ring-cleaving dioxygenase involved in the degradation pathway of the Pseudomonas aeruginosa quorum sensing signal molecules HHQ (2-heptyl-4-quinolone) and PQS (2-heptyl-3-hydroxy-4(1H)-quinolone) to anthranilate.  Catalyzes the cleavage of PQS to form N-octanoylanthranilate and carbon monoxide.  Thus, leads to the inactivation of PQS that plays a central role in the regulation of virulence factor production by P. aeruginosa, thereby quenching the production of antimicrobials, which may contribute to the competitiveness of M. abscessus in presence of P. aeruginosa (PubMed:31228546, PubMed:28303132).  In vitro, can also use other 2-alkyl-3-hydroxy-4(1H)-quinolone (AHQ) substrates with shorter alkyl substituents at C2, but with lower efficiency (PubMed:31228546).
What are the official names of this protein?
2-heptyl-3-hydroxy-4(1H)-quinolone dioxygenase, PQS dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: RS4_PEDPA
Sequence: MSRYTGPSWKVSRRLGISLTGTGKELARRPYAPGDHGQNNRRKISEYGMQLREKQKLRMMYGLTERQFSNLFVRAGKIREGLPGTNFMVLLERRLDNMVYRLGLATTRRQARQLVNHGHITVDGKRVDIPSYEVEIGQVIGVREKSKDLKIISEAVEAVVGRPQFVQFDADKLEGSLVRLPQRDELEADIDDSLIVEYYNKL
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: ATPD_BACP2
Sequence: MSVTIVSKRYASALFDIVLASSAVDETEKELNEIKKVLKADQELNDFLVHPKITADKKKHLIAEAFKGVSTHVLHTMYLLIDRGRTNIFSEMTSEFVKLANRTKQIDDAIVYSVKPLSGAEIQSLSEVFAKKAGVTSLRVENVIDKDLIGGVKIRIGNRIYDGSVSGKLSRIERQLAGENR
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.