PharMolix/UniProtQA huggingface dataset:
Protein: IXTPA_SYNC1
Sequence: MEMLVATRNKGKLREIERLLADTDIVVKGLDAYGDLPDVVEDGATFAANARKKAATMARLTGCLTVADDSGLAVEALGGKPGIYSARYAGEEALDSDNNRKLLEDMASVPEGQRQAAFHCVMALCTPEGDCQLFDGRLDGVILTRGRGEGGFGYDPLFLVPEYGRTLAELPLDIKNRISHRGQALKRLVAYLHSPG
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: RL27_ECO24
Sequence: MAHKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: REGQ_BPAPS
Sequence: MRRDIQQVLERWGTWARDNNTGIDWSPIAAGFKGLLPLRPSMRPSCSDEDGRIIDNCVSQLQQVRQPEELSLIIAYYVKGYSKRAIARRRRVDEGLIRAKLLIAEGFIDGCLSLLAVRLDMDPEVKMYSPQKSGKRISAVRKKFVNVL
What is the function of this protein?
Positively regulates expression of some phage genes.  Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent expression of the regulated genes (By similarity).
What are the official names of this protein?
Probable antitermination protein Q, P5.
What is the protein family that this protein belongs to?
Belongs to the phage antitermination Q type 1 family.
Protein: DUT_ROSDO
Sequence: MALVSLKLQWADGADTSVPLPAYETSGAAGADIRANCPDGPVTLAPGARALVPTGLRMAIPQGYEVQIRPRSGLALRHGITLVNSPGTIDSDYRGAVGVIMQNLGDAAFEITHGMRIAQMVVAPVVQASFELSDSLSETDRGSGGFGSTGGD
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RIMO_LEPBA
Sequence: MPKSLENTNETPKSFFITTLGCPKNTVDSMAMHQSLLKEGLLPAAGPEASDFHLVNTCTFIQDATKETIQTILDSIDIKKQNKQKLVVVGCFAERAGKEISDDLPEVDLHFGTGKYDKAGEILRKNFPLEFKDLTEFNEDLLERLTTSKGIENYSKPYSYVKISDGCNRGCHFCIIPNLRGKYRDTDSNDVLEQTKLAVKAGSKEICLVSQDTVFYGKDTDKLMDLVRSVAAVEGLEILRLLYLYPDKKTEKLLDLYREIPKIAPYLESPLQHVSKSVLKSMNRTGDYEFFKSLFQKARDIRPDLEIRTSFILGFPGETMEDVEEIIRFVEDVKPEKVNLFPYSPQEGTKGATMDGQLKDKEIARRVNLVREAYLGTLKTIHQNRIGKIYPCVVDEVLDDGAIVRRLQDAPEIDEVVYVETKDLKLGQFGKVRVDSFYELDMSGTWVD
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XGHA_ASPOR
Sequence: MISLNSIFLLSLVGLSRAAPSRSETSPDRTIKPRAACTPTAGGSSSTDDVPAIQEAITSCGDGGIIIIPADTTYYLNSVLDFKGCSNCDFQVEGLLQFTSSTDYWNGKTAMITVSDIDGLKLRSVTGSGVIDGNGQESWDKFAEDSSYKRPTLLYITGGSNIEVSGLRQKNPPNVFISVKGDTSNAQFTSLTMDATSNSDNLPKNTDAFDIGASTYVTISSVAITNDDDCVAFKPGANYVTVENVSCTGSHGISVGSLGKSSDDTVQNVYARNITMINSSKAAGIKTYPSGGDHGLSTVKNATFEDFIVDGCDYAFQIQSCYGEDDTYCEENPGDAVLEGIVVKGFTGTTSDKEDPVVANLNCGSKGTCDVTISGFEVKAPSGDAKILCGNTPSDLGVTCSSGASG
What is the function of this protein?
Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin.  Activity requires a galacturonic acid backbone substituted with xylose (By similarity).
What are the official names of this protein?
Probable endo-xylogalacturonan hydrolase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: 5054R_ASFM2
Sequence: MFSLQDICRKHLFLLPSSFDEYILQALGLYWEKHGSLQRIRKDAVFVQRNIVLSTNEALRIAASEGNERVIKLLLSWEGDFHYVIIGALEGDRYDLIHKYVSQIKDYHNILSLIQNANTFEKCHHLSNSNMWCLIQNAIKYNMLSILQKHKNCLTHEGENQELFEMACEEQKYDIVLWIGQTLMVNEPESIFDTALARIDFSLLTIGYRLLFDNKMSCIDIHDEEDLTSSLTEHLEKAAIKGCFFFMLETLKHGGNVNMAVLSKAVEYNHRKILDYFIRRQKCLSREEIEKLLLSGISNGASIKTLNLLLSYLNYSVKHIIRKIVQYVIKEGDFTIIVVLKRKKINLVEPVLSGFMDDYYSYCFIKQFIDEFDIRPEKIIKMAARKGKLNMIIEFFNEIYPHKDDLKTMFKFLKNLVYTMKHKKGKEVLIGLIHKIYQSIHLENKEMFNLLKFYVMYNANIQFIALCKDCFKLAGFKPFLLECLDIAIKRNYPDIIQNIKLLLKYE
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 505-4R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 505 family.
Protein: CPXCR_MACFA
Sequence: MSSPTKEGSDTAGNAHKNSENEPSNDCTTDIESPSADPNMIYQVETNSINREPGTATSQEDAVPQAAANTELETEIQKDQREEDIKEEPLLLQIPIPRKLISLMSELGRGNYLRILLVKIDQNKPLNDRSKSHSEKAEMKANNCPVNRKIRFRLSTSWRVPFINNHEIRSMILRLLCERYFSQAEECQDTMWVKQNYIACLYRPNSFTHHERTVIFRRPLRVRYHRPLTERMTSGKFCKSTDMKGKYRFRAIVRSVLFVSHVQLQSLFNRKGFVDILRYNHTRKVMIISTNNGWKYFCPICGRLFNTYFELRRHSCRSPGN
What are the official names of this protein?
CPX chromosomal region candidate gene 1 protein homolog.
Protein: GL8D1_DANRE
Sequence: MTVRRVNVVILVLLVVAFLIVLHRNLLNLNDFLNQETSDTVPGMILPFETDFLLGRKAMRSGEEIPVLITAPEERLGAAVTAMNSIYRNSKANVVFNIVTLNESVVHLSTWLSKTDLKHKIIVFDPSILLGKIPTDAQKMETVRPLTFARFYMPAFLPDAEKAIYLDDDVIVQGDIRELFNTSLKSGHVAAFSEDCDSASSKGIVRGAGNQNSYIGYLDFKKEAIKKLGMRANTCSFNPGVFVANLTEWKQQNVTSQLEFWMERNAKEDLYSKTLADCMTTPPMLIVFYKHHSNIDPMWNVRHLGATGAGNRYSAQFVKAAKLLHWNGHYKPWGRTSSFSDIWDKWYIPDPTGKFHPIRKHVEEK
What are the official names of this protein?
Glycosyltransferase 8 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RRG9_PICST
Sequence: MLRLVQSNTGFRSLSCRLLSSTKLVTPRFWYSQDNSKAEEIFKRKLIAREKEFRSRLPQWEKRDISLKKRYGVWNPTKKVSRVQMQDIRSLKLQMPNLKTVDMANMFGVSPESIRRILNSKWQPSENDMKKLEKRAERRKAESRERKEQSEQDLKDGVRRIHRAKTIKLQNVRYKETDAINEKDTSKKTASKRQSHAVTGKQGKMKTTIDKPFVPSVADLIK
What is the function of this protein?
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
What are the official names of this protein?
Required for respiratory growth protein 9, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG9 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RHP23_SCHPO
Sequence: MNLTFKNLQQQKFVISDVSADTKISELKEKIQTQQNYEVERQKLIYSGRILADDKTVGEYNIKEQDFIVCMVSRPKTSTSTPKSAASPAPNPPASVPEKKVEAPSSTVAESTSTTQTVAAAAPSNPDTTATSEAPIDANTLAVGAQRNVAVENMVEMGYERSEVERAMRAAFNNPDRAVEYLLTGIPEDILNRQREESAAALAAQQQQSEALAPTSTGQPANLFEQAALSENENQEQPSNTVGDDPLGFLRSIPQFQQLRQIVQQNPQMLETILQQIGQGDPALAQAITQNPEAFLQLLAEGAEGESALPSGGIQIQITQEESESIDRLCQLGFDRNIVIQAYLACDKNEELAANYLFEHGHESEDEP
What is the function of this protein?
Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.
What are the official names of this protein?
UV excision repair protein rhp23, RAD23 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACCD_CELJU
Sequence: MSWLEKIIPSISRTETKRSNKVPEGLWEKCVKCDAVLYKPELEKNLDVCPKCDHHMRIGARSRLNIFLDPQNRQELATDVEPVDRLKFKDIKKYKDRLSSAQKDTGEKDALIAMRGELKGMPVVAVAFEFAFHGGSMGYVVGERFTRAATVALNENIPLVCFSATGGARMQEALISLMQMAKTSAVIERLKMQGTPYVSVMTDPVYGGVSASLALLGDINVAEPGARAGFAGPSIIEQTIRQKLPKGFQRAEFLLEHGAIDMIIHRGEMRDKLASLLAKFTRRAAV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYQ_HAEIN
Sequence: MMSHTETSLGAENTRTHNFITQIIDEDLASGKHKSVHTRFPPEPNGYLHIGHAKSICLNFGLAKEYQGLCNLRFDDTNPVKEDVEYVDSIKADVEWLGFKWEGEPRYASDYFDALYGYAVELIKKGLAYVDELSPDEMREYRGTLTEPGKNSPYRDRTIEENLALFEKMKNGEFAEGKASLRAKIDMASPFMVMREPVIYRIKFSSHHQTGDKWCIYPMYDFTHCISDAIERITHSICTLEFQDNRRLYDWVLENISIERPLPHQYEFSRLNLEGTLTSKRKLLKLVNDEIVDGWNDPRMPTISGLRRRGYTPASLREFCRRIGVTKQDNVVEYSALEACIREDLNENAPRAMAVIDPVRVVIENFESEAVLTAPNHPNRPELGERQLPFTKELYIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDANGEITTIFCTYDPETLGKNPADGRKVKGVIHWVSAVNNHPAEFRLYDRLFTVPNPGAEDDIESVLNPNSLVIKQGFVEQSLANAEAEKGYQFEREGYFCADSKDSRPEHLVFNLTVSLKEGF
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPT_BURL3
Sequence: MTHPTELPLSPLSALQFYATAPYPCSYLDGRVARSQVATPSHLINSDIYTELVKAGFRRSGVFTYRPYCDGCRACVPVRVPVDAFAPSRTQRRMWKRHRTLVATVSPLHYDEEHYALYMRYQSARHAGGGMDRDSRDQYEQFLLQSRINSRLVEFRDLDAPGGEPGKLRMVSMIDILGDGLSSVYTFFEPDDQHTSYGTYNILWQIEQAKSLGLPYVYLGYWIRESPKMAYKANFHPLEGLIDGRWKILDPERIDLPPVDAALARAPLPGGHSGSG
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLAB4_PYRHO
Sequence: MRKGAIGIGTLIVFIAMVLVAAVAAGVIIGTAGYLQQKAQAAGRQTTQEVASGIKIVNVFGYINATPPSNGTIVKMAILVTPNAGSSGIDLSNVKIVLSDGKRLAVYNYSGVLYTGKILDLFNLTIWKNTSNGTFSIAVVNDVGSKMENHHPTLEWGDTVALLLRTDDVFEYEGKGGIGPSTKIIGKVIPDAGAAGVIDFTTPPTFGYNVLELQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
What are the official names of this protein?
Flagellin B4.
What is the protein family that this protein belongs to?
Belongs to the archaeal flagellin family.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: SYA_BURCM
Sequence: MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLMFTNSGMVQFKDVFLGTDPRPYSRATTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKHDAIRFAWELLTTVYQLPKEKLWVTVYQEDDEAYDIWAKEVGVPTERIIRIGDNKGARYASDNFWTMGDTGPCGPCTEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKQSVDTGMGLERLAAVLQHVHSNYEIDLFQNLIKAAARVTEISDLTNNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKLGRKGSFFHKLVADLVAEMGAAYPELKEAEQRVTDVLRQEEERFFETIEHGMSILEAALADVEAKGGKVLDGELAFKLHDTYGFPLDLTADVCRERGMTVDEPAFDDAMARQREQARAAGKFKATQGLEYSGAKTTFHGYEEIAFDDAKVVALYVDGSAVNEVKAGQDAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVADTLKVQADVVGHHGTLEQGTLKIGDVLRAEIDAHRRARTQRNHSATHLMHKALREVLGAHVQQKGSLVDAEKTRFDFAHNAPMTDDEIRRVEQIVNNEILANAPGIVRVMPYDEAVKGGAMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGFFKIVVEGGVAAGIRRVEAITGDNAVRYVQELDARVNEAAAALKAQPSELTQRIAQVQDQVKSLEKELGALKSKLASSQGDELAQQATEIGGVYVLAATLDGADAKTLRETVDKLKDKLKSAAIVLAAVEGGKVSLIAGVTPDASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPANLPGALAGVKGWVEERL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHI_SOLBU
Sequence: MLPMITEFINYGQQTIRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTISNLPQINNE
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: SUMO1_XENTR
Sequence: MSDQEAKPSSEDLGDKKEGGDYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRISDHQTPKELGMEEEDVIEVYQEQTGGHSTI
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer (By similarity).  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).
What are the official names of this protein?
Small ubiquitin-related modifier 1, SUMO-1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane. Nucleus.
Protein: ATPB_RHOPS
Sequence: MATPANQTGRITQVIGAVVDVQFEGHLPAILNAIETKNGDNRLVLEVAQHLGESTVRTIAMDTTEGLVRGQEVTDTGSPIMVPVGIGTLGRIMNVIGEPVDEQGPVANEGLRPIHAEAPLYTDQSTEAEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIQELINNVAKAHGGYSVFAGVGERTREGNDLYHEFIESGVNKKGGGEGSKCALVYGQMNEPPGARARVALSGLTVAEHFRDQGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGALQERITTTHKGSITSVQAIYVPADDLTDPAPATSFAHLDATTVLNRAISEKGIYPAVDPLDSTSRMLSPLIVGEEHYQTARMVQQVLQKYKSLQDIIAILGMDELSEEDKLAVARARKIERFLSQPFFVAEIFTGSPGKFVDLADTIKGFRAICEGKYDHLPEAAFYMVGAIEEAVEKGKKLAAEAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RPO1C_PYRAE
Sequence: MISREELLSKLSQVLPQPLYKEVEEAVRDLDDEKALRLVYRVLKLYVTSLIDPGEAIGIVTAQSIGEPGTQMILRSFHYAGLREFSMARGLPRLIEVVDARRTPSTPLMYVYLKPPYNKSREAAESVAKKIQQVTLETLAKEVDVDYVAGTVTITLDQEQLKYRGLTLKDVEKIVAKAKGKDVAISMRGYTITASLTTPDILKIRKIKDKILQIKISGIKGVRKVVLQYDSKNDEWYIVTEGTNLEAVLQLEEVDPTRTYSNDLHEVEEVLGIEATRALVAQEIKRVLEEQGLDVDIRHMYLVADAMTWSGRLRPIGRHGVVGSKESPLARAAFEVTVKTLIEASVRGEDELFKGVVESIIAGKYVPIGTGIVRLLMQF
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDM8_MOUSE
Sequence: MSEDTTEPLVGSSTLWKELRTLLPDKEEELKLDLGEKVDRSVAALLRQAVGLFYAGHWQGCLQASEAVLDYSWEKLNTGPWRDVDKEWRRVYSFGCLLKALCLCQAPQKATTVVEALRVCDMGLLMGAAILEDILLKVVAVLQTHQLPGKQPARGPHQDQPATKKAKCDASPAPDVMLERMVPRLRCPPLQYFKQHFLVPGRPVILEGVADHWPCMKKWSLQYIQEIAGCRTVPVEVGSRYTDEDWSQTLMTVDEFIQKFILSEAKDVGYLAQHQLFDQIPELKRDISIPDYCCLGNGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVLGRKYIRLYSPQESEAVYPHETHILHNTSQVDVENPDLEKFPKFTEAPFLSCILSPGDTLFIPAKYWHYVRSLDLSFSVSFWWS
What is the function of this protein?
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase.  Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation.  Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4.  After initial cleavage, continues to digest histones tails via its aminopeptidase activity.  Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1).  The histone variant H3F3A is the major target for cleavage.  Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established.  Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1.  Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation.  Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition.  Required for G2/M phase cell cycle progression.  Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation.  Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity).  Regulates the circadian gene expression in the liver (PubMed:30500822).  Represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a catalytically-independent manner (By similarity).  Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822).
What are the official names of this protein?
Bifunctional peptidase and arginyl-hydroxylase JMJD5, JmjC domain-containing protein 5, Jumonji C domain-containing protein 5, L-arginine (3R)-hydroxylase KDM8, Lysine-specific demethylase 8.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3).
Protein: PANB_LISMC
Sequence: MKRPVDFFAMKENGEKITMITAYDYPSAKNVEQAEADMILVGDSLGMVVLGYDSTVPVTMDDMIHHTKAVKRGAPDTFVVTDMPFMTYHGSVDETIQNARKIIQESGAHAVKLEGAGEVVNKIARLTEAGAPVVAHLGLTPQSVGLTGSYKVRAKSAQEAQELMDNALAVEAAGAIALVLEAIPRQLAEKVSKALSIPTIGIGAGVETDGQVLVYHDIIGYGISRRAKFVKAYADIDERIEPALASYVKEVKAATFPEVKHSFTMAEEDLKGLYGRE
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3PG_TRYBB
Sequence: MTIKVGINGFGRIGRMVFQALCDDGLLGNEIDVVAVVDMNTDARYFAYQMKYDSVHGKFKHSVSTTKSKPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTVKSAAEGHLRGGARKVVISAPASGGAKTFVMGVNHNNYNPREQHVVSNASCTTNCLAPLVHVLVKEGFGISTGLMTTVHSYTATQKTVDGVSVKDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQGKLTGMAFRVPTADVSVVDLTFIATRDTSIKEIDAALKRASKTYMKNILGYTDEELVSADFISDSRSSIYDSKATLQNNLPNERRFFKIVSWYDNEWGYSHRVVDLVRHMAARDRAAKL
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal, GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Glycosome.
Protein: METE_STAHJ
Sequence: MTTITTSNLGFPRLGRKREWKKAIESYWAKKIDKAELDQKISDLHRENLLLQKHYNLDSVPVGDFSLYDHILDTSLLFNIIPERFQGREVNDDLLFDIARGNKEHVASALIKWFNTNYHYIVPEWDNVEPKVNHNVLLDRFNYAKSLNVNAHPVIVGPITFVKLSKGGHQSFEEKVQTLLPLYKEVLQALVDAGAEYIQVDEPVLVTDESEAYEAITREAYDYFDKAGLADKLVIQTYFERANVKFLSSLPVGGLGLDFVHDNGYNLKQIESGDFDSSKTLYAGIIDGRNVWAADIEAKKKLIETLQGHAKHIVIQPSSSLLHVPVSLDDETLEQSIEEGLSFATEKLDELDALRRLFNQNDSAKYDKLKARYERFQSQSFKNLEYDFDSVPTSRKSPFPERKKAQDARLHLPDLPTTTIGSFPQTQEVRKYRADWKNKRISDEAYNNFLESEIARWIKIQEDIGLDVLVHGEFERNDMVEFFGEKLQGFLVTKFGWVQSYGSRAVKPPVIYGDVKWTEPLTVKETVYAQSLTDKPVKGMLTGPVTILNWSFERVDVPRKVVQDQIALAIDEEVLALEEAGIKVIQVDEPALREGLPLRSEYHEQYLADAVNSFKLATSSVQDETQIHTHMCYSQFGQIIHAIHELDADVISIETSRSHGDLIKDFEDINYDLGIGLGVYDIHSPRIPTEDEIATAIDRSLQQIDRSLFWVNPDCGLKTRKEDEVKDALTVLVNTVRKKRASNNQNKPA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: TVA27_HUMAN
Sequence: MVLKFSVSILWIQLAWVSTQLLEQSPQFLSIQEGENLTVYCNSSSVFSSLQWYRQEPGEGPVLLVTVVTGGEVKKLKRLTFQFGDARKDSSLHITAAQTGDTGLYLCAG
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 27.
What are the subcellular locations of this protein?
Cell membrane.