PharMolix/UniProtQA huggingface dataset:
Protein: MAMG_MAGGM
Sequence: MIKGIAGVGGTALGVGGGVAAPPVSAAAVGSTLLAGKGVCLGLGLGLGAWGPVLLGVAGLACAASLCDYLKNRKAQAEASAEPA
What is the function of this protein?
Plays a role in regulating magnetite crystal size.
What are the official names of this protein?
Magnetosome protein MamG.
What is the protein family that this protein belongs to?
Belongs to the magnetosome MamG (TC 9.B.95) protein family.
What are the subcellular locations of this protein?
Magnetosome membrane; Multi-pass membrane protein. Note=Localizes as a filament-like structure in a straight line running through the center of the cell, in a position that corresponds to magnetosomes.
Protein: SUCD_RICBR
Sequence: MAILVNKKTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTPGKGGKTHLDLPIYNTVHEAKAKTGANASVIYVPPPFAADSILEAIDAGIEIVVCITEGIPVLDMVRVKRALVGSRTRLIGPNCPGIITPDECKIGIMPGHIHRKGSIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPVNGTNFVDCIDMFLQDDETKAIIMIGEIGGDAEENAADFIKHSKIKKPIVSFIAGITAPPGKRMGHAGAIIAGGKGSAEDKLEALQSAGVTITRSPADIGKTMLDLLNG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit alpha, Succinyl-CoA synthetase subunit alpha, SCS-alpha.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase alpha subunit family.
Protein: FIBA_MANLE
Sequence: ADTGDGDFITEGGGVR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: LEUC_XYLF2
Sequence: MAGKTLYGKLWDIHEVARRDDGSSLIYIDRHILHEVTSPQAFEGLRLAGRPLWRVNANIATPDHNVPTTKAERQGSLLSIADTVSRLQVQTLDENCDDFGIFEFKMNDVRQGIVHVIGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVTQKMKNMQVRVEGTLPWGVTAKDIVLALIGKIGTAGGNGYAVEFSGSTIRALSMEGRMTICNMAIEAGARVGMVAVDEKTIQYVHGRPFAPKGSDWDAAVAFWRGLVSDPDAHFDRVVELSAEEIKPQVTWGTSPEMVSAVDQSVPDPERETDPVKKESLIRALKYMGLQPNDPITSIKLDRVFIGSCTNSRIEDLRAAAEVVKGRKVASTVKQAMVVPGSGLVKAQAEVEGLDKIFIEAGFEWREPGCSMCLAMNPDKLGSGEHCASTSNRNFEGRQGIGGRTHLVSPAMAAAAAVAGHFVDVREMMR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: GSA_MARN8
Sequence: MNHSETLFEQAQKYIPGGVNSPVRAFRGVGGTPVFFKHAEGAYLYDEDDRRYIDFIGSWGPMILGHSDPRIKAALHAQVDLGVGYGAPTAIETEMAKKVCELVPSIELVRMVNSGTEATMSAIRLARGYTGRDKIVKFEGCYHGHVDSLLVKAGSGALTLGVPNSPGIPASLAEHTLTLTYNDIDEVRETFRQMGDQIAAIIVEPVAGNMNCIPPVPGFLEALREVCDEHGTVLIFDEVMTGFRVSLGGAQGFYGVKPDLTALGKVIGGGLPVGAFGGKREIMEHISPLGPVYQAGTLSGNPLAMTAGLTTLNAISEPGFHDRLTEKTNRVKDGFKAAADEAGIPLAVQSAGAMFGFFFTAEPSITRFDQVMACDVERFKAFFQGMLKEGVYLAPSAFEAGFTTAALSDEDIEFTLAAARKVMKTL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MERA_BACCE
Sequence: MKKYRVNVQGMTCSGCEQHVAVALENMGAKAIEVDFRRGEAVFELPDDVKVEDAKNAIADANYHPGEAEEFQSEQKTNLLKKYRLNVEGMTCTGCEEHIAVALENAGAKGIEVDFRRGEALFELPYDVDIDIAKTAITDAQYQPGEAEEIQVQSEKRTDVSLNDEGNYDYDYIIIGSGGAAFSSAIEAVALNAKVAMIERGTVGGTCVNVGCVPSKTLLRAGEINHLAKNNPFVGLHTSASNVDLAPLVKQKNDLVTEMRNEKYVNLIDDYGFELIKGESKFVNENTVEVNGNQITAKRFLIATGASSTAPNIPGLDEVDYLTSTSLLELKKVPNRLTVIGSGYIGMELGQLFHNLGSEVTLIQRSERLLKEYDPEISEAITKALTEQGINLVTGATYERVEQDGDIKKVHVEINGKKRIIEAEQLLIATGRKPIQTSLNLHAAGVEVGSRGEIVIDDYLKTTNSRIYSAGDVTPGPQFVYVAAYEGGLAARNAIGGLNQKVNLEVVPGVTFTSPSIATVGLTEQQAKEKGYEVKTSVLPLDAVPRALVNRETTGVFKLVADAKTLKVLGAHVVAENAGDVIYAATLAVKFGLTVGDLRETMAPYLTMAEGLKLAVLTFDKDVSKLSCCAG
What is the function of this protein?
Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase.  MerA protein is responsible for volatilizing mercury as Hg(0).
What are the official names of this protein?
Mercuric reductase, Hg(II) reductase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Protein: RLMN_DELAS
Sequence: MNTNLLDFDLDGLAAYCEQLGEKRFRATQLFRWIHQRGASDFDQMSDLAKSLREKLKACAHITALPVLTEHVSADGTVKWLFDVGGGDAVEAVFIPEDDRGTLCVSSQAGCAVGCRFCSTGHQGFSRNLSTGEILAQLWYAEHSLRKRLGTGGERVISNVVMMGMGEPLQNYTALVPALRAMLDDHGYGLSRRRVTVSTSGVVPMIDRLSQDCAVAMAVSLHAPNDELRDPLVPLNRKYPIHELLDACERYLEFAPRDFITFEYCMLDGVNDQPEHARQLIELVRARGDGRSWCKFNLIPFNPFPASGLLRSPAARVTEFASLLSNAGIVTTVRKTRGDDIDAACGQLAGDVKDRTRAAERMARQRTIVLKQVP
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_YERPG
Sequence: METIAKHRHARSSAQKVRLVADLIRGKKVSQALETLTYTNKKAAGLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: KIME_BOVIN
Sequence: MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRRAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVPRSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRALSGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL
What is the function of this protein?
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
What are the official names of this protein?
Mevalonate kinase, MK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome.
Protein: RXL7_GEOTN
Sequence: MSYEKVLQAGKIVIGTKQTIRALKEGKAAEVIVAEDADLPIIEKVMAAANEANVPITKVDSMKKLGKACKIQVGAAAVAILR
What are the official names of this protein?
Putative ribosomal protein L7Ae-like.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
Protein: RL11_NEIG2
Sequence: MAKKIIGYIKLQIPAGKANPSPPVGPALGQRGLNIMEFCKAFNAATQGMESGLPIPVVITAFADKSFTFVMKTPPASILLKKAAGLQKGSSNPLTNKVGKLTRAQLEEIAKTKEPDLTAADLDAAVRTIAGSARSMGLDVEGVV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: URED_BURP0
Sequence: MSAHEPHTSLVRPAAKAWHARLELGFERQPGGRTALAHRRHVGPLRVQRALYPEGDAICHAVIVHPPGGVAGGDRLEIDVRLDAGTHAVLTTPGATKWYKSNGLDARQRIDIDVGAHAKLDWLPQNNLFFDAAHASLEFVLALGDGASVLGWDATQLGRQAAGEAWSAGSIASFSKIVGPSGRPLWVERARLDAGDPLRAAPQGLGGFAVYGTLWALGAACTEALAESIAPALPFDDALRAGVTCVAPGTLLIRALAHSMEALQRLLAEQWLALRPIVHGVDPKPLRLWQT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OOXA_AGRT4
Sequence: MTLREVSVATDLSDFYDLLVIGAGPAGMAAAVEASASGARVAVLDENPRPGGQIYREITRNSPDRRTYLGPDYWKGQPLAEAFCLSNVDYASRATVWSLETRDKTAGQARNVVGVTVAGSARMVETNAVVLATGAQERPMPVPGWTLPGVMTAGAAQIALKAAGAMPAGPVVLIGCGPLLYLLASQLVDAGVPDLTVLDTAQSPFRGAVLRHMPEFLLSPYVLKGIGLLLKVRRHAQVVYGVRSIAIIGSQHAESVRYAVGQGERSIPAKSVLLHQGVIPSTSLSNAAGCELQWNDEQRAFQPVTDHDGRTTKAGIYVAGDGAGIAGAQAAEVSGRLAALAALADLKLVSTQTSSTSIKSRHAQARRFLRGRAFLDALYTPRQSFLAPSAPETIVCRCEEITVRKLREAIALGPPGPNQLKTFVRCGMGQCQGRLCAATVTEIMVAEERKVSPADVGTYRLRSPVKPVRLAELAHLPHTARALKAVTGRDPVDHDTTETGHIL
What is the function of this protein?
Oxidative cleavage of octopine into L-arginine and pyruvate.
What are the official names of this protein?
Opine oxidase subunit A, Octopine oxidase subunit A.
What is the protein family that this protein belongs to?
To T-protein and to dimethylglycine dehydrogenase.
Protein: SELO_BORBR
Sequence: MKWLRLQDLPTDNSFAALPAEFYTRLQPRPPAAPRLLHANAEAAALIGLDPAEFSTQAFLDVFSGHAPLPGGDTLAAVYSGHQFGVWAGQLGDGRAHLLGEVRGPAGGWELQLKGAGMTPYSRMGDGRAVLRSSVREYLASEAMHGLGIPTTRSLALVVSDDPVMRETVETAAVVTRMAPSFVRFGSFEHWSARRQPEQLRVLADYVIDRFYPECRVAGAGRLDGEHGEILGLLAAVTRRTALLMADWQAVGFCHGVMNTDNMSILGLTLDYGPYGFMDTFQLGHICNHSDSEGRYAWNRQPSVGLWNLYRLASSLHTLAPDPEALRAVLDGYEAVFTQAFHGRMAGKLGLPQFLPEDETLLDDLLQLMHQQGADFTLAFRRLGEAVRGQRQPFEDLFIDRAAAGAWYDRLAARHASDGRAAQARAAAMDEVNPLYVLRNHLAEQAIRAAARGDAGEIDILLKLLRNPYKQQPGYDAYAGLAPDWAAGLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: PUR5_BURCJ
Sequence: MNPPKSAPDAQGLSYRDAGVDIDAGDALIDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVVKGIAQGCELSGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLALMQKLSVKGMAHITGGGLVENIPRVLREGLTAELDQNAWPLPPLFKWLQEHGGVADAEMHRVFNCGIGMAVIVSAADADAAIADLTAAGEQVWKIGTVRATREGEAQTVVV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP1_POVLY
Sequence: MAPQRKRQDGACKKTCPIPAPVPRLLVKGGVEVLEVRTGPDAITQIEAYLNPRMGNNIPSEDLYGYSNSINTAFSKASDTPNKDTLPCYSVAVIKLPLLNEDMTCDTILMWEAVSVKTEVVGISSLVNLHQGGKYIYGSSSGCVPVQGTTYHMFAVGGEPLELQGLVASSTATYPDDVVAIKNMKPGNQGLDPKAKALLDKDGKYPVEVWCPDPSKNENTRYYGSFTGGATTPPVMQFTNSVTTVLLDENGVGPLCKGDKLFLSCADIAGVHTNYSETQVWRGLPRYFNVTLRKRIVKNPYPVSSLLNSFFSGLMPQIQGQPMEGVSGQVEEVRIFEGTEGLPGDPDLNRYVDKFCQHQTVLPVSNDM
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins.  Interacts with a N-linked glycoprotein containing sialic acids on the cell surface to provide virion attachment to target cell.  Once attached, the virion is internalized by endocytosis and traffics to the endoplasmic reticulum.  Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating.  Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal.  In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA.
What are the official names of this protein?
Major capsid protein VP1, Major structural protein VP1.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses coat protein VP1 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: ARCH_DROME
Sequence: MEVEFSRENFLLPEMKYEYLDHTADVQIHGWGSSLKEAFEQCGVAMFGYMTELDYVSVEQCFEIEAHGDDLESLLFHFLDELLFLFSAEPYLVCKKLEITKFDVENFEISCHCYGEPFELGKHPQGTEVKAITYSAMQIIQDVEASNYEVFVIIDI
What is the function of this protein?
Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (CG9987).
What are the official names of this protein?
Protein archease-like.
What is the protein family that this protein belongs to?
Belongs to the archease family.
Protein: RL22_STRSY
Sequence: MAEITSAKATARTVRVSPRKSRLVLDNIRGKSVADAIAILKFTPNKAAGIIEGVLNSAIANAENNFGLEKANLVVSEAFANEGPTLKRFRPRAKGSASPINKRTAHITVVVAEK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: MAP2_YEAS6
Sequence: MTDAEIENSPASDLKELNLENEGVEQQDQAKADESDPVESKKKKNKKKKKKKSNVKKIELLFPDGKYPEGAWMDYHQDFNLQRTTDEESRYLKRDLERAEHWNDVRKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYTGAENLLAMEDPKSQGIGFPTGLSLNHCAAHFTPNAGDKTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEINGETYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDTTKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEDHQVMPTLDSAKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFALNNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEVVSKGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2, MAP 2, MetAP 2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_SCIAE
Sequence: MTNIRKTHPLLKIVNHSFIDLPAPSNISAWWNFGSLLGLCLLIQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWLIRYMHANGACLFFICLFLHVGRGLYYGSYTYFETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFSPFHFILPFIIAALVMVHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDVLGVLLLLLLFMTLVLFTPDLLGDPDNYAPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILMLFPILHVSKQRSMMFRPLSQCLFWILAADLFTLTWIGGQPVEHPFITIGQVASILYFMIILFALPSISMLENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PURA_HERAR
Sequence: MAKNVVVVGTQWGDEGKGKIVDWLTDHSQGVVRFQGGHNAGHTLVIGGHKTALQLIPSGIMREGVACYIGNGVVLSVPDVLREIDKLHAIGVEVPSRLKISEACPIILPYHTALDVAREVARGDAKIGTTGKGIGPAYEDKVARRAIRAADLLNEKRFAEKLRENLDYHNFVLANYLKVATVDYQKTLDDALADVPRLKPMVGDVSSALYAAFNAGANLLFEGAQGSLLDVDHGTYPYVTSSNCVAGNASTGSGVGPGMLHYILGITKAYTTRVGSGPFPSELPTDQGVGKHLATVGHEFGTVTGRARRCGWFDAALLKRSVQINGVTGMCFTKLDVLDGLETLRICTGYKLNGKIVDIFPVGAEDAAACEPIYEEMPGWKEATVGAKTLEALPANARAYIDRIEKLVGVPIDMISTGPDREETIVLRHPFK
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_CLABR
Sequence: MSLTSRLYKLRLSSLHSFGSLPILPPPLRSSRIAAPLSLRVSLSTRSIATSIAMGEAADAGMDAVQRRLMFDDECILVDEVDRVVGHESKYNCHMWEKIESGNMLHRAFSVFLFNSKFELLLQQRSATKVTFPLVWTNTCCSHPLYRESELIDENNLGVRNAAQRKLLDELGIPAEDVPVDEFTPLSRMLYKAPSDGKWGEHELDYLLFIVRDVAVHPNPDEVAEIKYVNREQLKELLKKADAGEEGLKLSPWFRLVVDNFLPKWWDHVEKGTLSEAVDMKSIHKL
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase II, Isopentenyl pyrophosphate isomerase II, IPP isomerase II.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
Protein: CUPC9_CANPG
Sequence: EVLLEGPSGVLFKDGQKKYLPPGVKIVLLTESGAVLSNGDNVQF
What are the official names of this protein?
Cuticle protein CP466, CPCP466.
Protein: RLMN_SALSV
Sequence: MSEQIVTPESSTPVVLNNETKINLLDLNRQQMREFFKNLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLTNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDTIRDEIVPINKKYNIETFLGAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKETPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEVIDIKAI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 6PGL_HAEIN
Sequence: MNYISFPTAQHAVDKIAQEFVIYSQLNHPVHISLSGGSTPKLLFKTLAKSPYAEQINWKNLHFWWGDDRMVPPSDPESNYGEVQKLLFDHIQIPAENIHRIRGENEPHFELKRFEEELSAVIPNGVFDWIILGMGIDGHTASLFPHQTNFDDENLAVIAKHPESGQIRISKTAKLIEQAKRITYLVTGESKADILKEIQTTPAENLPYPAAKIKAKNGVTEWYLDKAAVRLL
What is the function of this protein?
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6PGL.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Protein: ESTP_DROME
Sequence: MSIFKRLLCLTLLWIAALESEADPLIVEITNGKIRGKDNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKPKKPNRSSFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNNVNSKEYQVLRISRNACKNEEYARFP
What are the official names of this protein?
Esterase P, Est-P, Carboxylic-ester hydrolase P, Carboxylesterase-P.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: NIFZ_SINFN
Sequence: MSIGREEEVEIHNPPRFMPGERVCATRHIKNDGTYPGKEIGERLVRKGDAGFVRDVGTFLQQFYIYAVEWIDRGIVVGMRTRELRSLGGTSTPKTTECARGVNEGKAR
What are the official names of this protein?
Putative NifZ protein.
What is the protein family that this protein belongs to?
Belongs to the NifZ family.
Protein: SOX2_SHEEP
Sequence: MYNMMETELKPPGPQQTSGGGGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM
What is the function of this protein?
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity).  Binds to the proximal enhancer region of NANOG (By similarity).  Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity).  Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).  Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).  May function as a switch in neuronal development (By similarity).
What are the official names of this protein?
Transcription factor SOX-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: METXA_LEPME
Sequence: MPTSEQNEFSHGSVGVVYTQSIRFESLTLEGGETITPLEIAYETYGTLNEKKDNAILVCHALSGDAHAAGFHEGDKRPGWWDYYIGPGKSFDTNRYFIISSNVIGGCKGSSGPLTINGKNGKPFQSTFPFVSIGDMVNAQEKLISHFGIHKLFAVAGGSMGGMQALQWSVAYPDRLKNCIVMASSSEHSAQQIAFNEVGRQAILSDPNWNQGLYTQENRPSKGLALARMMGHITYLSDEMMREKFGRKPPKGNIQSTDFAVGSYLIYQGESFVDRFDANSYIYVTKALDHFSLGTGKELTKVLAKVRCRFLVVAYTSDWLYPPYQSEEIVKSLEVNAVPVSFVELNNPAGRHDSFLLPSEQQDSILRDFLSSTDEGVFL
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.