PharMolix/UniProtQA huggingface dataset:
Protein: AROE_EXISA
Sequence: MNLAVIGHPIAHSLSPQLHEQWLRASGLFGRYEAIDATPDQLPALFAAMREGDWDGFNVTIPYKEVVVRYLDDLDEAAKHAGAVNTVYKRDGRLIGTNTDGAGLVQALMPYTDFRGHVLIVGAGGAARGIVQALPTRDVTIVNRTVERAKALADTFGVVYTTFDEMDVSRYDVIIQTTSVGMDERSTPLSLEGLRQNTVVCDIIYRPLVTPMLQEAKSRGANIVTGVAMFVGQGALSFEKWTGVKPDETVGKKLIEGLLEE
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: CSPL1_IPONI
Sequence: VAPTGSVETEKAGPSYKPKEYYKVTEAILRLLLLASLVVAVVVMVTSKETELISVKLDPFPPFMLPLTAKFTQSPAFIYFVAGLSVAGLYTIISTLASFYNLLIKPGFCPALVSHFIILDVVMLGIVGTATGAAGGVAYIGLKGNSHVGWTKVCNKYGKLCTHLGASLAVSFFAFIVLLLLIILSIHSLSKKIPK
What are the official names of this protein?
CASP-like protein IN26, CASP-like protein 1D1, InCASPL1D1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTA_SALTY
Sequence: MSRIIMLIPTGTSVGLTSVSLGVIRAMERKGVRLSVFKPIAQPRAGGDAPDQTTTIVRANSTLPAAEPLKMSHVESLLSSNQKDVLMEEIIANYHANTKDAEVVLVEGLVPTRKHQFAQSLNYEIAKTLNAEIVFVMSQGTDTPEQLNERIELTRSSFGGAKNTNITGVIINKLNAPVDEQGRTRPDLSEIFDDSSKAQVIKIDPAKLQESSPLPVLGAVPWSFDLIATRAIDMARHLNATIINEGDIKTRRVKSVTFCARSIPHMLEHFRAGSLLVTSADRPDVLVAACLAAMNGVEIGALLLTGGYEMDARISKLCERAFATGLPVFMVNTNTWQTSLSLQSFNLEVPVDDHERIEKVQEYVANYVNAEWIESLTATSERSRRLSPPAFRYQLTELARKAGKRVVLPEGDEPRTVKAAAICAERGIATCVLLGNPDEINRVAASQGVELGAGIEIVDPEVVRESYVARLVELRKSKGMTEPVAREQLEDNVVLGTLMLEQDEVDGLVSGAVHTTANTIRPPLQLIKTAPGSSLVSSVFFMLLPEQVYVYGDCAINPDPTAEQLAEIAIQSADSAIAFGIEPRVAMLSYSTGTSGAGSDVEKVREATRLAQEKRPDLMIDGPLQYDAAVMADVAKSKAPNSPVAGRATVFIFPDLNTGNTTYKAVQRSADLISIGPMLQGMRKPVNDLSRGALVDDIVYTIALTAIQASQQQQ
What is the function of this protein?
Involved in acetate metabolism.  Catalyzes the reversible interconversion of acetyl-CoA and acetyl phosphate.  The direction of the overall reaction changes depending on growth conditions.  Required for acetate recapture but not for acetate excretion when this organism is grown on ethanolamine (EA); is unable to complement an eutD deletion during growth on EA (PubMed:16272400).  Works with proprionate kinase PduW to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD) (PubMed:12700259).
What are the official names of this protein?
Phosphate acetyltransferase, Phosphotransacetylase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPB_CAMJE
Sequence: MANIQDFLTDNMLSNLESAASLAIHSKNNEVVPLHLLWALSVDSTSILNQILNKLNISKEALELEIKSRISKLATSSNVNRENIRFSNELINSLENAKGLMSANGDSYLSVDTWLISESQKSPIKEILAQFLDLREFQKELESLRAGRKMDSKTSDETLDSLNKFGIDLTLKASEGKLDPVIGREEEIERLMQILIRKTKNNPILLGEPGVGKTAIVEALAQRIIKKDVPKSLQNKKVIALDMSALIAGAKYRGEFEDRLKAVVNEVIKSENIILFIDEIHTIVGAGASEGSMDAANILKPALARGELHTIGATTLKEYRKYFEKDAALQRRFQPVNVGEPSVNEALAMLRGIKEKLEIHHNVTINDSALVAAAKLSKRYIADRFLPDKAIDLIDEAAAELKMQIESEPSSLRKVRKDIETLEVENEALKMENDEKNQKRLDEIAKELANLKEKQNALNSQFENEKSVFDGISAKKKEIDLLKNEASLAKARGEFQKAAELEYGKIPSLEKEVEILEDKWKKMSENGVLLKNQVDEDLVAGILSKWTGISVQKMLTSEKQKFLEVEKHLKESVIGQDKALSALARAIKRNKAGLNADNKPIGSFLFLGPTGVGKTQSAKALAKFLFDDEKAMIRFDMSEFMEKHSVSRLLGAPPGYIGHEEGGELTEAVRRKPYSVLLFDEVEKAHKDVFNVLLGILDDGRATDSKGVTVDFKNTIIILTSNIASNAIMNLSGKEQEDAVKNELKNFFKPEFLNRLDDIITFNPLGKDEAYEIVKLLFKDLQMSLENKGIKASLSENAALLIAKDGFDPDFGARPLRRAIYDLIEDKLSDMILADELHENDSIIIDAKDDEIIIKKA
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAHC1_PSEPU
Sequence: MSKQAAVIELGYMGISVKDPDAWKSFAMNMLGLQVLDEGEKDRFYLRMDYWHHRIVVHHSAEDDLEYLGWRVAGKPEFEALGQKLIDAGYKIRVCDKVEAQERMVLGLMKTEDPGGNPTEIFWGPRIDMSNPFHPGRPLHGKFVTGDQGLGHCIVRQTDVAAAHKFYSLLGFRGDVEYRIPLPNGMTAELSFMHCNARDHSIAFGAMPAAKRLNHLMLEYTHMEDLGYTHQQFVKNEIDIALQLGIHANDKALTFYGATPSGWLIEPGWRGATAIDEAEYYVGDIFGHGVEAPGYGLDVKLS
What is the function of this protein?
Involved in the naphthalene catabolic pathway.  Catalyzes the meta-cleavage of 1,2-dihydroxynaphthalene (1,2-DHN) to yield 2-hydroxychromene-2-carboxylic acid.  Can also cleave 3-methylcatechol and 4-methylcatechol.
What are the official names of this protein?
1,2-dihydroxynaphthalene dioxygenase, 1,2-DHN dioxygenase, DHNDO, 1,2-dihydroxynaphthalene oxygenase.
What is the protein family that this protein belongs to?
Belongs to the extradiol ring-cleavage dioxygenase family.
Protein: SYN_COLP3
Sequence: MSVISITDVLAGNFPVNESITIHGWIRTRRDSKAGISFLALHDGSCFDAIQAIVPNELDNYESDVLKLTTGCSVKVTGILVESPGKGQAFEIQATEVEVLGFVEDPDTYPMAAKRHSIEFLREQAHLRPRTNIGGAVTRVRNCLAQAVHRFLHSKGYFWISTPLITGSDCEGAGEMFRVSTLDMENLPRNDEGKVDYNKDFFGKETFLTVSGQLNVETYCNALSKVYTFGPTFRAENSNTTRHLAEFWMVEPEIAFADLSDAADLAEEMLKYVFKAVLEERPDDMAFFQQRVDKTVLDRLNSVINTDFVRLDYTDAITILENCGKKFENQVSWGVDLNSEHERYLAEEHFNGPVVLQNYPKDIKSFYMRLNDDGKTVAAMDILAPGIGEIIGGSQREERLDVLDSRLEEMGLDIADYGWYRDLRRYGTVPHSGFGLGFERLVAYATGMQNVRDVIPFPRTPNNAAF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYN_STAES
Sequence: MKTTIKQAKKHLNQEVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEETFQLAKDITQESSLYITGTITEDNRSDLGYEMQVKSIEIVHEAHDYPITPKNHGTEFLMDHRHLWLRSKKQHAVMKIRNEIIRATYEFFNENGFTKIDPPILTASAPEGTSELFHTKYFDEDAFLSQSGQLYMEAAAMAHGRVFSFGPTFRAEKSKTRRHLIEFWMIEPEMAFTNHAESLEIQEQYVSHIVQSVLNHCQLELKALDRDTTKLEKVATPFPRISYDDAIEFLKKEGFDDIEWGEDFGAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPDNEDTVLCADLIAPEGYGEIIGGSERINDLELLEQRINEHELDEESYSYYLDLRRYGSVPHSGFGLGLERTVAWISGVEHVRETSPFPRLLNRLYP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_PROMA
Sequence: MSNEIKSISSSNSSCPPNEARSGERDKALSLVLGQIERNFGKGSIMRLGDASKMRVETISTGALTLDLALGGGYPKGRVVEVYGPESSGKTTLTLHAIAEVQKRGGVAAFVDAEHALDPVYAASLGVDIENLLVSQPDTGEMALEIVDQLIRSSAVDLVVVDSVAALTPRSEIEGEMGDHAVGSQARLMSQAMRKITGNIGKSGCTVIFLNQLRLKIGVTYGNPETTTGGNALKFYASVRLDIRRIQTLKRGTEEYGIRAKVKVAKNKVAPPFRIAEFDILFGKGISTLGCLLDMAEETNIVTRKGAWYSYEGDNIGQGRDNTITWLEENSEAKEKIEKLVRQKLTEGSEVSANSMKPLASAARAANTPPVMKKISNAA
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPA_ECO7I
Sequence: MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNDLINYLASPDETEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTNLIAFAMNLFDIIGINQDDRGDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQVMESLDQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: IPKB_RAT
Sequence: MTDVESVISSFASSARAGRRNALPDIQSSLATGGSPDLALKLEALAVKEDAKMKNEEKDQGQPKKPLDEDK
What is the function of this protein?
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
What are the official names of this protein?
cAMP-dependent protein kinase inhibitor beta, PKI-beta, cAMP-dependent protein kinase inhibitor, testis isoform.
What is the protein family that this protein belongs to?
Belongs to the PKI family.
Protein: CR2_HORVU
Sequence: GAHPISPYIYSLSSKFGHLADKDRNEIKEQLDPSASGGMNGYISLCGGDPSPLVFRSPVDGLEDIMDNQVICSIYKRSRSSQLRNGKVSRRRAPASGAARVLRREGAEREGCSDTRCRCRRRRRRVQGYGVAGLASCDAPHDPDAPHGTDAPHTPDAPYGSDSPATGNHYGYQYHYRPGGGASGGPCSPMIISTCTVYVPRS
What are the official names of this protein?
Cold-regulated protein 2.
Protein: METN_LACLN
Sequence: MTAIIELNNLSVQFHQKGRLVTAVKNATLHIEKGDIYGVIGYSGAGKSTLVRTINLLQKPTEGQIVINGEKIFDSENPVKFTGAKLREFRQKIGMIFQHFNLLSEKTVFNNVAFALQHSQIEDKNGKKRYLTKKEKNDKVTELLKLVDLADLSDKYPAQLSGGQKQRVAIARALANDPEILISDEGTSALDPKTTNQILDLLKSLHEKLGITVVLITHEMQVVKEIANKVAVMQNGEIIEQNSLIDIFAQPKEALTKQFIETTSSVNRFIASLSKTELLAQLADDEELIHLDYSGSELEDPVVSDITKKFDVTTNIFYGNVELLQGQPFGSLVLTLKGSSEHRAAAKAYFVERHLKFEVLGKIERTVD
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SLYX_ECOLU
Sequence: MQDLSFEARLAELESRLAFQEITIEELNVTVTAHEMEMAKLRDHLRLLTEKLKASQPSNIASQAEETPPPHY
What are the official names of this protein?
Protein SlyX.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: PLY4_AMBAR
Sequence: MGIKHCCYILYFTLALVTLVQAGRLGEEVDILPSPNDTRRSLQGCEAHNIIDKCWRCKPDWAENRQALGNCAQGFGKATHGGKWGDIYMVTSDQDDDVVNPKEGTLRFGATQDRPLWIIFQRDMIIYLQQEMVVTSDKTIDGRGAKVELVYGGITLMNVKNVIIHNIDIHDVRVLPGGRIKSNGGPAIPRHQSDGDAIHVTGSSDIWIDHCTLSKSFDGLVDVNWGSTGVTISNCKFTHHEKAVLLGASDTHFQDLKMHVTLAYNIFTNTVHERMPRCRFGFFQIVNNFYDRWDKYAIGGSSNPTILSQGNKFVAPDFIYKKNVCLRTGAQEPEWMTWNWRTQNDVLENGAIFVASGSDPVLTAEQNAGMMQAEPGDMVPQLTMNAGVLTCSPGAPC
What is the function of this protein?
Has pectate lyase activity.
What are the official names of this protein?
Pectate lyase 4, Antigen Amb a II, Antigen K, AgK, Pollen allergen Amb a 2.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family. Amb a subfamily.
Protein: DABA_PSEMU
Sequence: MKFATSIVAAIATTGAAFTVIPQKLSHPSQLNALNTMGSISSITAESPKEVLSRVQDAGLTLTNPNDLYWMVDFLKEKYYDNGDYYYPIKTVCDGESIDVKFYCPFEPSLSPHYLELYGSRDERASIYETTMKKYNRINSEKTSAICTPYSSYGDTQIVAYFYSMMYYINDQTAHLKLPESEIESELIDILNDDILIYLNEFMSIFEPEDAQDLERIWDFLDFYQPYFSKVDGKIVLDEKYLVRTPSQMPLIKTICEYVSEQFAPSKNITQVIWEVVRYIKGVKDEIHIRGDKSFTLSLQEYDDFRDKVTASPMAHAVSDLTHERFSYEAYTNPAFMELENRCSEIITYFNDVCTSDRERLDEDPFNSVFILMDLDPSLNFAKSCDVVVEHAYNKMQAFLKLKEEILESASDEEERLALARMIKTREDSLIGYVLHEVCCVEDGYARDHKPLMKAFLEEEITKSLAEKVKFNPVESESVRLN
What is the function of this protein?
Magnesium-dependent glutamate N-prenyltransferase: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP) (PubMed:30262498).  Catalyzes the conversion of L-glutamic acid (L-Glu) to N-geranyl-L-glutamic acid (NGG) in the presence of geranyl diphosphate (GPP) (PubMed:30262498, PubMed:32457155).  Also able to catalyze the formation of farnesyl-L-glutamate from farnesyl diphosphate (FPP) (PubMed:32457155).  Cannot use dimethylallyl diphosphate (DMAPP) as substrate (PubMed:32457155).
What are the official names of this protein?
Magnesium-dependent glutamate N-prenyltransferase, Domoic acid biosynthesis cluster protein A, PmDabA.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: CPSF2_CAEBR
Sequence: MTSIIKLKVFSGAKDEGPLCYLLQVDNDYILLDCGWDERFELKYFEELRPYIPKISAVLISHPDPLHLGGLPYLVAKCGLTAPVYCTVPVYKMGQMFIYDLVYSHLDVEEFQHYSLDDVDMAFEKVEQVKYNQTVVLKGDSGVNFTAMPAGHMIGGSMWRICRITGEDIIYCVDFNHRKDRHLSGCSFDNFNRPHLLITGAHHISLPQMKRKDRDEQLVTKILRTVRQKGDCMIVIDTAGRVLELAYLLDQLWANQDAGLSTYNLVMMSHVASSVVQFAKSQLEWMDEKLFRYDSSSARYNPFTLKNVNLVHSHLELIKIRSPKVVLCSSQDMETGFSRELFLDWCADQRNGVILTARPASFTLAARLVELAERANDGVLRNEDKHLSLLVRKRVPLEGEELLEYKRRKAERDAEETRIRMERARRQAQANESDDSDDDDIAAPIVPRLSEKDHRSFDAIENDSHCFDIMAKWDNQQKASFFKSTKKSFPMYPYIEEKVKWDDYGEVIKPEDYTVISKIDMRKGKNKDEPVVVHKREDEEEVYNPNDHDEEMPTKCVEFRNRIEISCRVEFIEYEGISDGESTKKMLAGLMPRQIIIVHGSRDDTRDLYAYFTDNGFKKDQLNTPVANELIDASVESFIYQVSLSDALLAEIQFKEVSEGNSLAWIDARIQEKESIDNMLVAGASQLTIEDSLQEDAVEVVEEDVIPMETFQDDQNKQEASEENVAEGEKSNGQSKENDENASSIPIETQPKIRGTLILTPLPKKQIPVHQAIFVNDPKLSEFKNLLVDKGYKAEFFSGTLLINGGKCSILVERLDSKWRVLSQKTFTNFGSCSTTSLLFCK
What is the function of this protein?
CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition.
What are the official names of this protein?
Probable cleavage and polyadenylation specificity factor subunit 2, Cleavage and polyadenylation specificity factor 100 kDa subunit, CPSF 100 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYR_HYPNA
Sequence: MTSLAKNLSAAAGAAFEAMGLEARFGEVRRSDKPELADFQCNGAMAAAKAAGKNPREIAGEIAARLKEHASVLSAEVAGPGFINLRVSDAALSARAEHVRGDAMAGAEKAADAAVTVIDFGGANVAKPMHVGHLRSAVIGDTLQRICRFAGDEVTSDVHLGDWGLQMGHLVTELYDEQPGLIYFDAAYTGPYPAEPPVTIDDLGRLYPQASNKAKADAARNERSQKAVAEMQAGRPGYRALLRHFIEVSIEALKLDYGFLNVSFDLWKGESDVDGLIPGLVERFKQAGLAEESDGALIVHVARETDKKEMPPVMLVNSRGGTGYHTTDLATILDRMDTLTTTPERMLYVVDQRQALHFEQVFRAAGMLGLIAEDKLEHIGFGTVNGADGKPFKTREGGVLRLADLQAMAMEEAEKKLSAANLPADMGDAERFDVAKKVAVAALRFSDLMNTRTTNYVFDLERFTSFEGKTGPYLMYAAVRVKSVLRKAAENGHSAGKVVVTEDAERTLVLQLDGFGAALLGAREKRMPHILCEHLYGLAQAFSSFYAALPIAAEADGEKRASRLALADGVRHQLETGLELLGIAVPERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_BUCBP
Sequence: MYLNTLSPNSKSHKKSKRVGRGIGSGFGKTSGRGHKGQKSRSGCKIRRGFEGGQMPLYRRIPKFGFVSLKKEKVAEVRLEDLKNFSNCIINLQFLKKTGLIKKNIKYVKIISSGSIITNILIIRNLFVSKSVRNIIESSGGKIEENN
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ARHG3_CHICK
Sequence: MVAKDYPFYLTVKRANCALDVEAASSPAKETEEPSNKRVKPLSRVTSLANLIPPVRATPLKRFSQTLQRSISFRSDSRPDLFSPRPWSRNTPAANTKRRDSKLWSETFDVCVNHMLTSKEIKRQEAIFELSKGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLRRLQEVRKSDGSTEHVGHILVGWLPCLNSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDHPDQQHLEEAINIIQGIVAEINIKTGESECQYYKERLIYLEGGQRDSLIDNSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAITHNEQLCYQLYRQPIPVMDLVLEDLQDGEVRLGGSIRGAFSNNERIKNFFRVSFKNGSQSQSHSLQANDSFNKQQWLNCIRQAKEKVTCAGKAGVLSSEACFILSPNGSRVSQGETMIEQMDQSDSESDCSMDTSEISIDCERMEQTNPCENEKQIETNV
What is the function of this protein?
Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
What are the official names of this protein?
Rho guanine nucleotide exchange factor 3.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_VIBC1
Sequence: MIQMQSMLDAADNSGARSVMCIKVLGGSHRRYAHIGDVIKVTVKEAIPRGKVKKGDVLKAVVVRTRKGVRRPDGSVIRFDRNACVLLNDNTEQPIGTRIFGPVTRELRGDKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MSCL_YERPS
Sequence: MSFMKEFREFAMRGNVVDLAVGVIIGAAFGRIVSSLVADIIMPPLGLLLGGVDFKQFHFVLRAAEGTIPAVVMNYGTFIQSIFDFVIVALAIFSAVKLMNKLRREKAEEEPATPPAPTTEEILLAEIRDLLKAQHTK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEUD_SALSV
Sequence: MAEKFTQHTGLVVPLDAANIDTDAIIPKQFLQKVTRTGFGAHLFNDWRFLDEKGQQPNPEFVLNFPEYQGASILLARENFGCGSSREHAPWALTDYGFKVVIAPSFADIFYGNSFNNQLLPVTLSDAQVDELFALVKANPGIKFEVDLEAQVVKAGDKTYSFKIDDFRRHCMLNGLDSIGLTLQHEDAIAAYENKQPAFMR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: GSFE_PENAE
Sequence: MPKTAFITGANGLSGSAIVEYLCNTTTSDDWGSIIVTSRSPFKSTVMDPRIKFIALDFVNDVSSLVETMKEVCGAVTHAYFCSYLHKDDFAESYTVNKALFENFIAAIDKAAPKLENVTLQTGGKYYNLHVEPVPSPARENDPRRYGPFENFYFTQEDTLAEMQRGKTWSWNVIRPEAIIGANSQPYGLNVALTIAMYFLICRELGSASPMPTNQRYWEGTDDVSYAPLIADLTIFVSTRKSCANEAFNVTNGDYFTWRYMWPRLAASLGAKADSQQCFEKPMPGEGELQLDWSLAEWCKDKRKVWEDLCDRQGLPGAKATFDLAGWAVGDFLYQRTWSATLSVNKARRFGWTGHMDSYQSFVDTFDKFRQLGLIPK
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections (PubMed:20534346, PubMed:23978092).  The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units (PubMed:20534346, PubMed:23978092).  The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone (PubMed:23978092).  However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C (PubMed:23978092).  Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B (PubMed:23978092).  The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin (PubMed:23978092).  Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin (PubMed:23978092).
What are the official names of this protein?
Short chain dehydrogenase gsfE, Griseofulvin synthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. Highly divergent.
Protein: RS14Z_STRP1
Sequence: MAKKSMIAKNKRPAKHSTQAYTRCEKCGRPHSVYRKFKLCRVCFRELAYKGQIPGVVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z, 30S ribosomal protein S14-1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: CMCH_STRCL
Sequence: MLVVAFKPGHDGAVAAIDDRRLLYSLESEKDSRPRYSTLLPTTFLDIAERLGAIPDVVALGGWADLRPRGVVYTGAGYEGTQEPTVTTSRFFGKEVKFFTSTHERSHIYMALGMAPKDGAPLKSVLVWEGDVGAFYLVDSEHRIIRTIPVMTGPGARYSFLFGLADPTFPDTGGKPRLNDAGKLMALAAFGDSADASPDIRHVVERVLKQDSMYPAPKAEYRDSVLHNAGVESEECKIAAALLTERLFETFAEVARRELPEGTPLYISGGCGLNCDWNSQWAQLGHFSSVFVAPCTNDSGSALGTAIDALTTFTGDPHIDWNVYSGLEFVHDTRPDPARWESVPLDHAALSSALAAGRVVAWVQGRWEIGPRALGNRSLLAEAFSSASRDRLNTVKMREDYRPIAPVCRVEDLGKVFHEDFEDPHMLYFRRVREESGVRAVTHVDGSARCQTVTGTSNPELHRLLSVFAQGQGLGVLCNTSLNFNGDGFINRMSDLVRYCEWREIQDMVVGDTWYRRIAGS
What is the function of this protein?
Catalyzes the carbamoylation reaction in the cephamycin biosynthesis.
What are the official names of this protein?
3'-hydroxymethylcephem-O-carbamoyltransferase, 3'-hydroxymethylcephem-O-CASE, CCT.
What is the protein family that this protein belongs to?
Belongs to the NodU/CmcH family.
Protein: RLP6_ARATH
Sequence: MTGLYSSMSFFLRTIVLLFSTSSFCNTFASLTQDSCHPDQRDALLEFKNEFKIWYPNGFLDIDGVLMDVTSYPKTKSWTKNSDCCYWDGITCDTKSGKVTGLDLSCSCLHGRLEPNSSLFRLQHLQSVNLAYNNFTNSPIPAEFSKFMRLERLNLSRSSFSGHISIKLLQLTNLVSLDLSSSFPYSPSSLSIEKPLFLHLLALNFMNLRELDMSSVDISSAIPIEFSYMWSLRSLTLKGCNLLGRFPNSVLLIPNLESISLDHNLNLEGSLPNFLRNNSLLKLSIYNTSFSGTIPNSISNLKHLTSLKLQQSAFSGRIPSSLRSLSHLSNLVLSENNFVGEIPSSVSNLKQLTLFDVSDNNLNGNFPSSLLNLNQLRYIDICSNHFTGFLPPTISQLSNLEFFSACDNSFTGSIPSSLFNISSLTTLGLSYNQLNDTTNIKNISLLHNLQRLLLDNNNFKASQVDLDVFLSLKRLVSLALSGIPLSTTNITSDSEFSSHLEYLELSGCNIIEFPEFIRNQRNLSSIDLSNNNIKGQVPNWLWRLPELSTVDLSNNSLIGFNGSLKALSGSKIVMLDLSSNAFQGPLFMPPRGIQYFLGSYNNFTGYIPPSICGLANPLILDLSNNNLHGLIPRCLEAQMSSLSVLNLRNNSLDGSLPNIFMNAKVLSSLDVSHNTLEGKLPASLAGCSALEILNVESNNINDTFPFWLNSLPKLQVLVLRSNNFRGTLHNVDGVWFGFPLLRITDVSHNDFVGTLPSDYFMNWTAISKSETELQYIGDPEDYGYYTSLVLMNKGVSMEMQRILTKYTVIDFAGNKIQGKIPESVGILKELHVLNLSSNAFTGHIPSSLANLTNLESLDISQNKIGGEIPPELGTLSSLEWINVSHNQLVGSIPQGTQFHRQNCSSYEGNPGIYGSSLKDVCGDIHAPRPPQAVLPHSSSSSSEEDELISWIAACLGFAPGMVFGLTMGYIMTSHKHEWFMDTFGRRKGRSTRTR
What are the official names of this protein?
Receptor-like protein 6, AtRLP6.
What is the protein family that this protein belongs to?
Belongs to the RLP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.