PharMolix/UniProtQA huggingface dataset:
Protein: ALLB_ECO8A
Sequence: MSFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASGLVVSPGMVDAHTHISEPGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLGELGQPVLVHCENALICDALGEEAKREGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHVCHISSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGMWEKLFNGEIDCLVSDHSPCPPEMKAGNIMEAWGGIAGLQNCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQKGRIAPGKDADFVFIQPNSSYVLTNDDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ
What is the function of this protein?
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
What are the official names of this protein?
Allantoinase, Allantoin-utilizing enzyme.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
Protein: EG15A_MDBVW
Sequence: MYIDTGIMSNNIFLFAFFALVGLTRIEAMPTKGSEGTWDVDYEDQEHTGITCRENEHYNSTRIECEDECNDRNNKLCYRFQQFCWCNEGYIRNSSHICVKLEDCLKDEEQKSETLASSANNDSSKRLEDDLKLFSHDSVSHTSLEPETQAQKFNGIINEETLDLVFGKPENSWAENKPLETKTQAQKFNGIINEETLDLVFGKPENSWAENKPLETETQAQKFNGIINEETLDLVFGKPENSWAENKPLETKTQAQKFNGIINEETLDLVFGKPENSWAENKPLETKTQAQKFNGIINEETLDLVFGKPENSWAENKPLETKTQTQKFNGIIDQYTRSIVFVF
What is the function of this protein?
Counteracts the host humoral immune response by inhibiting the processing and the amidolytic activity of host PAP1 and PAP3.  Thereby, melanization of host hemolymph, normally producing several reactive intermediates toxic for viruses, is deregulated and proper immune response cannot occur.
What are the official names of this protein?
Protease inhibitor Egf1.5a.
What is the protein family that this protein belongs to?
Belongs to the polydnaviridae EGF-like motif protein family.
Protein: R146A_BOVIN
Sequence: MMAGCGETDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDRPTLLSPELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKSTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVPAQSGASVQSSSVRPLTSVDGQLTSPATPSPDVGTSLEDSFAHLQLGGDSIAERSHRGEGEEEHESPSSGRVPAPDTSIEETESDASSDSEDVSALVAQHSLTQQRLLVPNPSQTVSDRSVAAGGIVSVRSRRPDGQCTVTEV
What is the function of this protein?
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.  Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex.  Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2.  Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF146-A, RING finger protein 146-A, RING-type E3 ubiquitin transferase RNF146-A.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: LUXA2_PHOLU
Sequence: MKFGNFLLTYQPPQFSQTEVMKWLVKLGRISEECGFDTVWLLEHHFTEFGLLGNPYVAAAYLLGATKKLNVGTAAIVLPTAHPVRQLEEVNLLDQMSKGRFRFGICRGLYNKDFRVFGTDMNNSRALMECWYKLIRNGMTEGYMEADNEHIKFHKVKVLPTAYSQGGAPIYVVAESASTTEWAAQHGLPMILSWIINTNDKKAQIELYNEVAQEYGHDIHNIDHCLSYITSVDHDSMKAKEICRNFLGHWYDSYVNATTIFDDSDKTKGYDFNKGQWRDFVLKGHKNTNRRVDYSYEINPVGTPQECIDIIQTDIDATGISNICCGFEANGTVDEIISSMKLFQSDVMPFLKEKQQFSYYIS
What is the function of this protein?
Light-emitting reaction in luminous bacteria.
What are the official names of this protein?
Alkanal monooxygenase alpha chain, Bacterial luciferase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the bacterial luciferase oxidoreductase family.
Protein: DPAA_BACSU
Sequence: MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTGAVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSGISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVLGLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICINTIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTAGQILANVLSKLLAEIQAEEGK
What is the function of this protein?
Together with DpaB, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA), which constitutes up to 10% of the dry weight of the spore.
What are the official names of this protein?
Dipicolinate synthase subunit A, DPA synthase subunit A, Spore dipicolinate synthase subunit A, Stage V sporulation protein FA.
Protein: DDL_LATSS
Sequence: MKIVVLAGGRSTERNVSLTSGHKITHALQTKGHDVAFVDLFLGNELKDGATIDSLYSSDPVEKDYDIDDEVLTDDDINKLREDGSTQLFGPNVLEICKTADIVFLALHGGDGENGKVQAVLDVFEIPYTGSDTLAAGITMSKKVSKEILLFNNIPTARFVAAYRHQPMPEMPFEYPVVVKPSNGGSSVGTHIVHNEAELKPAVEDALRFDNEALIEEFIKGREFSLGVINEQPLPAIEIEVNDGWYDFEHKFVTGNTTKFVTPPNNLPDDVHEAMKQMALDAMHALGLTNYARIDFFWSPETGLYVIEGNTLPGMTPLSLIPQEAEVLGISYPDLCEMIVNGKLALLNEK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLAV_ECOL6
Sequence: MAITGIFFGSDTGNTENIAKMIQKQLGKDVADVHDIAKSSKEDLEAYDILLLGIPTWYYGEAQCDWDDFFPTLEEIDFNGKLVALFGCGDQEDYAEYFCDALGTIRDIIEPRGATIVGHWPTAGYHFEASKGLADDDHFVGLAIDEDRQPELTAERVEKWVKQISEELHLDEILNA
What is the function of this protein?
Low-potential electron donor to a number of redox enzymes (Potential).  Involved in the reactivation of inactive cob(II)alamin in methionine synthase (By similarity).
What are the official names of this protein?
Flavodoxin 1.
What is the protein family that this protein belongs to?
Belongs to the flavodoxin family.
Protein: TM254_BOVIN
Sequence: MGKARGDEAYFQRSSLFWVTIIILSFGYYTWVIFWPESIPYQSLGPLGPFTQYLLKHHHTLVHAWYWLAWMIHVGESLYAIVLCKSKGITNTWTQLLWFLQTFLFGLASLYYLIAFRPKHQKQT
What are the official names of this protein?
Transmembrane protein 254.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TMM83_HUMAN
Sequence: MNCDALLHHSAIPEDFLHIFLLLQKISVSLPLSLSQSVCLFYSISLCVSLLLHISLCVSVYVSLSLSSFPCFSLTHTHTHSQLSKDTSVLTFTFCFKQHTHFTLNYTSHAHELSAPSVHPTCVFTFKAAPSPRPAT
What are the official names of this protein?
Putative uncharacterized protein encoded by LINC00052, Putative transmembrane protein 83.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GBB1_HOMAM
Sequence: MNDLDSLRQEAERLKNTIRDARKNALDTTLVQATAGMDPIGRIQMRTRRTLRGHLAKIYAMHWGSDSRNLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFVDDNQIVTSSGDMTCALWDIETGQQCTQFTGHTGDVMSLSLSPNMRTFTSGACDASAKLWDIRDGMCRQTFPGHESDINAVTFFPNGHAFATGSDDATCRLFDIRADQELAMYSHDNIICGITSVAFSKSGKLLLAGYDDFNCNVWDSMRTERAGVLAGHDNRVSCLGVTEDGMAVATGSWDSFLKIWN
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
What are the official names of this protein?
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Transducin beta chain 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family.
Protein: THIO_BOVIN
Sequence: MVKQIESKYAFQEALNSAGEKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVVFLEVDVDDCQDVAAECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELI
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).  Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide.  Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity.  Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Secreted by a leaderless secretory pathway.
Protein: PYRDB_LISW6
Sequence: MNRLAVEIPGLSLKNPIMPASGCFGFGQEYSKYYDLNKLGAIMAKAVTPEPRLGNPTPRVAETASGMLNAIGLQNPGLEHVLAHELPFLEQFETPIIANVAGATEDDYVEVCSRIGESKAVKAIELNISCPNVKHGGIAFGTDPEVAHRLTKAVKSVASVPVYVKLSPNVADIVSIAQAIEAAGADGLTMINTLLGMRIDLKTRKPIIANGTGGLSGPAIKPVAIRMIHQVRSVSNIPIIGMGGVQTVDDVLEFLIAGADAVAVGTMNFTDPFICPKLITELPIRMDELGISSLQELKKERANQ
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_METSB
Sequence: MPTISQLIRKPRQEKTYREKARHLGASPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHILRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ISPG_BRUSI
Sequence: MSSETVSYFSHPFPRRQSVGVSVGGVIVGGSAPVVVQSMTNTDTADVDSTVAQVVALHRAGSEIVRITVDRDESAAAVPKIRERLERLGHDVPLVGDFHYIGHKLLADHPACAEALAKYRINPGNVGFKDKKDKQFADIVEMAIRYDKPVRIGVNWGSLDQELLTTLMDRNQAEGAPLSAQDVMREAIVQSALISANLAEEIGLGRDKIILSAKVSQVQDLIAVYTMLAQRSNHALHLGLTEAGMGTKGIVASSAAMGILLQQGIGDTIRISLTPEPGGDRTREVQVAQELLQTMGFRQFVPIVAACPGCGRTTSTVFQELAQTIQEDIRRNMPLWREKYPGVEALSVAVMGCIVNGPGESKHADIGISLPGTGETPSAPVFVDGKKVATLRGPGIAEDFQKMVADYIENRFGLGRKIAS
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: TIG_STRPJ
Sequence: MSVSFENKETNRGVLTFTISQDQIKPELDRVFKSVKKSLNVPGFRKGHLPRPIFDKKFGEESLYQDVMNALLPNAYEAAVKEAGLEVVAQPKIDVTSMEKGQDWVIAAEVVTKPEVKLGDYKNLEVSVDVEKEVTDADVEERIERERNNLAELVIKEAAAENGDTVVIDFVGSIDGVEFDGGKGENFSLGLGSGQFIPGFEDQLVGHSAGETVDVIVTFPEDYQAEDLAGKEAKFVTTIHEVKAKEVPALDDELAKDIDEEVETLADLKEKYRKELAAAKEEAYKDAVEGAAIDTAVENAEIVELPEEMIHEEVHRSVNEFLGNLQRQGINPDMYFQITGTTQEDLHNQYQAEAESRTKTNLVIEAVAKAEGFDASEEEIQKEVEQLAADYNMEVAQVQSLLSADMLKHDITIKKAVELITSTATVK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: SYC_PROMT
Sequence: MSLKFTNTLSKKKEDFISINPNQVKIYCCGVTVYDLCHLGHARSYLNWDVLRRFLIWKGFEVKFVQNFTDIDDKIINRANKEGCSTDELSERNIDEFHKDMDTLSILRPTSMPRATKCLHQIINFIEELEQKKVAYSSNGDVYFSVDKHKNYGKLSGREIEDQIDNAAGRLKTNQKESKKNSLDFALWKKSNSGEVSYSSPWGNGRPGWHIECSAMVKQELGESIDIHLGGSDLIFPHHENEIAQSEACNGKELAKYWLHNGMVNVGGEKMSKSLGNFTTIRSLLEEDISPMTLRFFVLQTNYRKPLDFTEEALKAASKGWERLNNCLSFGYIYKIKDQSKNEIFLDKPIKKSANTKLDKNSFKLLSDFEKYMDDDLNTSGALSILFELSQPIRKIINFLKEKDINEVDQDELNQVFNKWELLSELAGVLGLKVNLNQEKPKNNPELDTNKIEELIKNRSLAKANKDFLLADKIRADLKNIGIDLIDKPKGVTEWKQLSD
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_MACCJ
Sequence: MGFIKKMFDGNKKEVKSLRKVADQVQTFEEEMKSLSDEALQNKTKEYQVELQKIEDYKQQEAYLNKILPEAYAVVREASRRVLGMFPFPVQIMGGTAIHRGDIAEMRTGEGKTLTATMPVYLNALTGRGVHVVTVNEYLASVQAEEMSHLYNFLGLTVGVNLNSLTTEEKRAAYACDITYSTNNELGFDYLRDNMVTYKEERVMRPLNFAIIDEVDSILIDEARTPLIISGQAEKSTSMYIQANVFVKMLKDDIDYTYDEKTKGIQLTENGIDKAERMFKVDNLYDVKNVNLMHHINIALKAQRAMLKDIDYVVEDGEIVIVDQFTGRTMPGRRFSEGLHQAIEAKEAVEIQNESKTMASITFQNFFRMYNKLSGMTGTAKTEEEELLNIYNMAVTQIPTNKPVQRIDGADLIYASEKGKFHAVVDEVIRRHKEGQPVLLGTVAVETSEYISELLKKKGIRHNVLNAKNHEREAEIVQNAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVIGTERHESRRIDDQLRGRAGRQGDPGYSRFYLSLQDELMVRFGSDRMSTMMTKLGMNDDQPIESKMVSRAVESAQKRVEGNNYDSRKRTLEYDDVLRKQREIIYAERNEILEKDDCSDQVKAMIEQSVRRAVDYHFTGDENEYDYEAFKNYAEDMYLTEGALSVDEISRRDNEEIYDIVMSKVMAQYQHQKEELQEQFHEFERMIMLRTIDMKWTDHIDTMDQLRTGIHLRSYGQINPLREYQNEGLTLFDTMLESIEDDVSKYILKSIIDRGEQVEREQVGKGEAMVANDGKEKVKQQPKVKSEPDIGRNEPCPCGSGKKYKNCHGRG
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: Y226_SULNB
Sequence: MAKDHYFDISAKLDMMEMKNAIEQAKKEVSTRFDFKGIMVEIDLNEKAKVLNLSSSSDSKIDALKDIVMSKMIKRGLSTKSLDEVKTEGISGGNVKVVYRIVDSIEKDEAKKIVKAIKDAKLKVTPSIQGDEIRVTGKKIDDLQAVIALVKQMEDLKAPLTFGNFK
What are the official names of this protein?
UPF0234 protein SUN_0226.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: GLMS_STRR6
Sequence: MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEDGLSVLEAFKKALHIIRGSYAFALIDSENPDVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNSRERASYTAELDLSDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDAGQVVIDPAIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPVELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTKAYTAQIAALAFLAKAVGEANGNAKAQAFDLVHELSIVAQSIESTLSEKETIEAKVRELLETTRNAFYIGRGQDYYVAMEASLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTTVHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPE_PARPJ
Sequence: MSGTLALTEQLIARASVTPDDQHCQRLLIERLAALGFEHETIESNGVTNLWAVKRGVDGTAGKLLAFAGHTDVVPTGPLEQWRSAPFEPTHRDGKLYGRGAADMKASIAGFVVASEEFVAAHPAHRGTIAFLITSDEEGPATDGTVKVVEALQERGERMDYCIVGEPTSSAQFGDMVKNGRRGSMSGKLIVKGVQGHIAYPHLAKNPVHLLAPALAELVAERWDDGNEYFPPTTWQVSNIHSGTGATNVIPGHADVMFNFRFSTASTVEGLQARVHAILDKHGLEYDLQWTVSGLPFLTPRGDLSNALAKAIKDETGLNTELSTTGGTSDGRFIARICKQVIEFGPLNASIHKIDEHIEVAHIEPLKNVYRRVLEQLIA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: PHOQ_SALTS
Sequence: MNKFARHFLPLSLRVRFLLATAGVVLVLSLAYGIVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKISVELPENLDMQSPTMTLIYDETGKLLWTQRNIPWLIKSIQPEWLKTNGFHEIETNVDATSTLLSEDHSAQEKLKEVREDDDDAEMTHSVAVNIYPATARMPQLTIVVVDTIPIELKRSYMVWSWFVYVLAANLLLVIPLLWIAAWWSLRPIEALAREVRELEDHHREMLNPETTRELTSLVRNLNQLLKSERERYNKYRTTLTDLTHSLKTPLAVLQSTLRSLRNEKMSVSKAEPVMLEQISRISQQIGYYLHRASMRGSGVLLSRELHPVAPLLDNLISALNKVYQRKGVNISMDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDDHLHIFVEDDGPGIPHSKRSLVFDRGQRADTLRPGQGVGLAVAREITEQYAGQIIASDSLLGGARMEVVFGRQHPTQKEE
What is the function of this protein?
Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides.  Essential for intramacrophage survival of S. typhimurium.  In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG).  In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG.  Essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system SsrB/SpiR (SsrA) and Pir at transcriptional and post-transcriptional levels respectively.  Promotes expression of the two-component regulatory system PmrA/PmrB via activation of pmrD gene.  Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells.  Negatively regulates prgH, which is required for invasion of epithelial cells.  Involved in acid tolerance (Probable).
What are the official names of this protein?
Virulence sensor histidine kinase PhoQ, Sensor histidine protein kinase/phosphatase PhoQ.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RK35_GRATL
Sequence: MCKLRTSKSIIKRFKFKSKNKILRRMAGRSHLLQKKSSKRKQKLRKIVNLKKIDISSWKFRVPYID
What are the official names of this protein?
50S ribosomal protein L35, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYE_DECAR
Sequence: MKPVRTRFAPSPTGYLHIGGARTALFSWAYARRHGGDFILRIEDTDVARSTPEAVQAILDGMQWLGLEHDEGPFYQMQRMDRYKEVIQQMLANGSAYYCYTTREELDALRAEQEAKKEKPRYDGRWRPEAGKALPVPPTDVPPVIRFKNPQGGVVAWDDQVKGRIEFANTELDDLIIARADGTPTYNFCVCVDDWDMGITHVIRGDDHVNNTPRQINILKALGAEVPTYAHLSMILGDDGAKLSKRHGAVSVMQYDEEGFLTEAVINYLARLGWSHGDDEVFSRQQFVEWFDLDHITASAAQFNTEKLLWLNQHYMKQLPPAELAAKVQARLTARGVDTANGPDLEKAVVLYVDRSNTLNVLADAVEVFYAHVTPNPELLAQHLADDARPALAEFAAGIATVTWEAPAINALIKETVTKHGLKMPKLAMPLRVILTGQAQTPAVDAVIALIGRDKVAATLAAYL
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTV1_MOUSE
Sequence: MPHRKKKPFIEKKKAVSFHLVHRSQRDPLAADETAPQRVLLPTQKVNDEERRAEQRKYGVFFDDDYDYLQHLKEPSGPAELIPSTSFATPLCDKTEDPCVYSSTGIKLPSSVFASEFEEDVGLLNKAAPVSGPRLDFDPDIVAALDDDFDFDDPENLLEDDFILQANKPTGGERMDTESEEDDGHEWEDMDDEEGSDDRSSAGFLSDGGDLSAPGSPQEAMKKHLFWEEETKSRFTEYSMTSSVMRRNEQLTLHDERFEKFYEQYDDVEIGALDNAELEGTIQVDSNRLQEVLNDYYKEKAENCVKLSTLEPFEDQDLPTNELDESEKEETITVVLEEAKEKWDCESICSTYSNLYNHPQLIKYEPKPKQIHLSSKTGIPLNVLPKKGLTAKQVERMQMINGSDLPKVSTQPRSKDETKEDKRARKQAIKEERKERRVEKKANKLAFKLEKRRQEKELLNLKKNIEGLKL
What are the official names of this protein?
Protein LTV1 homolog.
What is the protein family that this protein belongs to?
Belongs to the LTV1 family.
Protein: ACUR_CERS4
Sequence: MPLTDTPPSVPQKPRRGRPRGAPDASLAHQSLIRAGLEHLTEKGYSSVGVDEILKAARVPKGSFYHYFRNKADFGLALIEAYDTYFARLLDQAFLDGSLAPLARLRLFTRMAEEGMARHGFRRGCLVGNLGQEMGALPDDFRAALIGVLETWQRRTAQLFREAQACGELSADHDPDALAEAFWIGWEGAILRAKLELRPDPLHSFTRTFGRHFVTRTQE
What is the function of this protein?
A transcriptional repressor for its operon.  Probably binds to 2 operator sequences in the promoter.
What are the official names of this protein?
Transcriptional regulator AcuR.
Protein: SC161_CAEEL
Sequence: MRRYRIDSMKYEQRMNAGASGFDMSDWNNPYNASPPSSRGGDDDASSVNHSRPRRSRLDNDIPQPRRPILIQPARPVSQKSNRQGTGMSNGSRGLNSTFNGYDRTYSRYHQNSSRGPSEGFSGAPSARNASGYASDYANSRAGVGLLPNNHREPVRPRSTAAERYANASSMRNGFVYDSGESDKTSEELEEDEEEEEVRNFYMEGRAQGSRSVTNTLASEVYNSESESYYYGVVKLGSAIVDHVFRTMPPPEKYYKMPPIDRVAYVFYCAVNNKPYNNIDEFHVIFNREFYSYRGYGDSKDLALFKVCKRMQEEFSLKQLEADRLAYEKARQEAAESEKLDFNQHKIEEREEPKLNISQPEEVLSNGPLHYHSCLQFATIGVGGKLVIIKPAGTIDSITGHVLSTSSVHVDDLKTFLHFDEQSGKVIESVQNFKGPLIAGQTPTHSVRLYIQRQIDALRQIRNAGDVKKSEVVDALLVWQLLEIMVQQHGRVTGPDVATLLTNASEELGEKTGISSNGTSESGSKFEAKERFNKYLLGGHINEAVESAITDGLYADAMTLIRRLHPNDAKKIEEIEARFMNLRSIDDPFATLVAVSSDQPPPILTNSAFDDDNNWKRHAAIVLANLNSQTAMQTIYHLGLLLAKRERNCAADFCLLVVCILAGYDPFIPVAHDGDETSRKHIGLVHSGSNLLNRVDGLSGTAGFSFTDLHATDIFDYALRLGNNNVDSPLAKSIDYQLARIEYAKKLSSFGGFATDAFRYCTEVARSLWMYVAAFDKNAMFDLCDLAESLQYMAAATPDESGWITTMRGMLGAAPVQESQQHVPQPQPVENKSISSEAKKWHDEHQAPLEIGSRNDQQHNDKTVEKPIAPGRASLPPPTLVTESSSESTFTDKSDSSVTVAASASRTSTLTSSTLPPPPSLPKTIEKPISTPPPISKNVVPEMTPPAIVKPPMPTLSMPIPPVSTPIMVSPQPIPIPKPVDASIAKSPRSELDDLWDTSPPSNQTSYPPAPRNIQPSYSPAPNFANPTAPSVPTPPPAVSSAPVLQQATLGQASIPNAKTTAPPVPQKQPELALNERKASKGWFGSIKEKVIKSIPSANQMILPDDSKPSIVWDPVQKRYVGAGVEEEVVAAPPPVMSAPHLMGGGPDSNKSSTNSLRSARSGVGSRYLQSGMATSQAPAMDTGMPPMMPPTMPMSFSFMPAPTEDDSSEYVDPFSGEPTAPSESLSKQNND
What is the function of this protein?
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:21478858).  In association with tfg-1, accumulates at ERES to positively regulate secretory cargo trafficking from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and Golgi apparatus (PubMed:21478858).
What are the official names of this protein?
Protein transport protein sec-16A.1, Secretory cargo traffic protein sec-16A.1.
What is the protein family that this protein belongs to?
Belongs to the SEC16 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Co-localizes with tfg-1 at endoplasmic reticulum exit sites (ERES).