PharMolix/UniProtQA huggingface dataset:
Protein: ASDA_COMTE
Sequence: MSKDYQSLAKLSPFELKDELIKIASSDGNRLMLNAGRGNPNFLATTPRRAFFRLGLFAAAESELSYSYMTTVGVGGLAKIDGIEGRFERYIAENRDQEGVRFLGKSLSYVRDQLGLDPAAFLHEMVDGILGCNYPVPPRMLNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAMAYIFESLKLNGLLKAGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPSLNWQYPDSELDKLKDPAIKIFFCVNPSNPPSVKMDQRSLERVRNIVAEHRPDLMILTDDVYGTFADDFQSLFAICPENTLLVYSFSKYFGATGWRLGVVAAHQQNVFDLALDKLQESEKVALDHRYRSLLPDVRSLKFIDRLVADSRAVALNHTAGLSTPQQVQMALFSLFALMDEADEYKHTLKQLIRRRETTLYRELGMPPLRDENAVDYYTLIDLQDVTAKLYGEAFSEWAVKQSSTGDMLFRIADETGIVLLPGRGFGSNRPSGRASLANLNEYEYAAIGRALRKMADELYAEYSGQAQNL
What is the function of this protein?
Bifunctional enzyme that has both L-aspartate decarboxylase and transaminase activity.
What are the official names of this protein?
Bifunctional aspartate aminotransferase and L-aspartate beta-decarboxylase, Aspartate 4-decarboxylase, ASD, AsdA.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: NADK_ECOHS
Sequence: MNNHFKCIGIVGHPRHPTALTTHEMLYRWLCTKGYEVIVEQQIAHELQLKNVKTGTLAEIGQLADLAVVVGGDGNMLGAARTLARYDIKVIGINRGNLGFLTDLDPDNAQQQLADVLEGHYISEKRFLLEAQVCQQDCQKRISTAINEVVLHPGKVAHMIEFEVYIDEIFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITLVPMFPHTLSARPLVINSSSTIRLRFSHRRNDLEISCDSQIALPIQEGEDVLIRRCDYHLNLIHPKDYSYFNTLSTKLGWSKKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIEF_YERPS
Sequence: MDPQYARWVKAAALSATALASILLIIKIFAWWHTGSVSLLAALVDSLVDLAASLTNLFVVRYSLQPADEEHTFGHGKAESLAALAQSMFISGSALFLFLTGFRHLASPEPLQDPSIGIGVTLVALFSTLILVTFQRWVVRKTHSQAIRADMLHYQSDVLMNGAILIALALSWYGFRRADALFALGIGVYILYSALRMGYEAVQSLLDRALPDDERQQIIDIVTSWPGVIGAHDLRTRRSGQTRFIQLHLEMEDMMPLMEAHVLAEQVEHALLYRFPGADVLIHQDPCSVVPKERHAHWEL
What is the function of this protein?
Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+).  May be involved in zinc and iron detoxification by efflux.
What are the official names of this protein?
Cation-efflux pump FieF.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL18_ECOLI
Sequence: MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that mediates the attachment of the 5S rRNA subcomplex onto the large ribosomal subunit where it forms part of the central protuberance.  Binds stably to 5S rRNA; increases binding abilities of L5 in a cooperative fashion; both proteins together confer 23S rRNA binding.  The 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L18, Large ribosomal subunit protein uL18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: BUT82_GIBZE
Sequence: MINITKPQNWTRGDYLVSTDPALLQVDAINAALSSDMVWWAGDLPADALWDALRSSICFGLYRKRSSEMNGTGPTVEYKIEEWEQVGLVRMITDGVTFGYLTDVYILPEHQGGGRGRWMLQILNEALQGWPHLRRVMLLTTDKMHLFGKNLGMKDYREFDGMKGVSIAMVEGPGAQH
What is the function of this protein?
Putative acetyltransferase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185).  Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable).  The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).
What are the official names of this protein?
Putative acetyltransferase FG08082, Butenolide biosynthesis cluster protein FG08082.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: SYT_RUBXD
Sequence: MATVRLPDGKELEVGSGERLEDVARRIGPRLARDAVVARLNGRLVDLDLPVDGGGELEFVTADSPEGLYVLRHSTAHAMAQAILELYPGSKLTIGPPVDDGFYYDIEVNGRISEEDLPRIEEKMREIARRDLPVRREEVSKEEARRLYRDNPYKLELIDEIPDERVSIYRQGDFFDLCRGPHVPSTGRLGAFKLQSVAGAYWRGDENNPMLTRIYGTAWPTEKQLRAYLKRLEEARARDHRRLGRELGLFTFAPEDVGPGIPLFLPKGETLRHLMEGFVREVQTRHGYQHVWTGHLVNERLYARSGHLEHYRDAMFPPMRDGEVSYRLKPMNCPSHMTLFNSRPRSYRELPVRYAEFATLYRYEKSGELSGLTRVRSLTQDDAHVFCTEEQVQEEFARALAIIREVLDAYGFTDYRVRLSLRDPEGGKYIADEEKWGRAEGALRAALDAAGIDYEPAPGEAAFYGPKADFMARDVLGREWQLSTIQVDFIQPGRLGCEYVGEDGERHTPVLLHRAVTGTTERFMAVLIEHYAGAFPVWLSPVQAVVIPVADRHLEYARRVREELSEGGLRVEVDDSPNSMQKKIRENARQKTPYLLIVGDREEEAGTVNVRRRGEGKRQTEMGLRGFLERVRGEVAARR
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_SHELP
Sequence: MAATGEALTPQGYIQHHLTNLHVGEGFWTWHIDSLFFSVGLGVLFLWLFRSVGKKATTGVPGKLQCFIEMIVEFVDGSVKETFHGRNPVIAPLALTIFVWVFMMNFMDMIPVDWLPWAAGLAGITHLKVVPTTDLNITFSLALGVFVLIIYYSIKVKGVSGFVKELTLQPFNHKAMIPVNLLLESVTLIAKPISLALRLFGNLYAGELIFILIALMYGANLALSALGVTLQLGWLIFHILVITLQAFIFMMLTIVYLSMAHEDH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PGK_LACAC
Sequence: MAKLIISDLDVKGKKVLVRVDFNVPIKDGVIGDDNRIVAALPTIKYIIEHGGKAILLSHLGRVKSDADKKELSLKPVAERLSELLDKPVTFVPSNEGKEVEEAIDNMKDGDVVVLENTRFQDIDNDFGKRESGNDPKLGEYWASLGDIFVNDAFGTAHRSHASNVGIATAMKENGKPAAAGYLLEKEIKYLGDAVDNPVHPFVTILGGAKVSDKIGVIENLIPKSDHILIGGGMAYTFLAAQGHKIGKSLFEADKVDLAKELLEKAGDKIVLPVDNVAATEFSNDASREVVGDDIPDNMMGLDIGPKTIAKFKDILKDAKTVVWNGPMGAFEMPNFAEGTLEVGRALANLTDATTIIGGGDSTAAAKQLGIAPKISHISTGGGASLNYLEGKVLPGIACVSDK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GTSFL_HUMAN
Sequence: MEPEAFEICPYDPHHRIPLSRFQYHLASCRRKNPKKAKKMATCKYNACHVVPIKNLEEHEAVCVNRSAVEEEDTENPLKVSPPSSEQNDDTQQVSPCLPSPDIWNVDGANCQHVFVLKTFFPQKVVCENDTKESARETSPQKILRPGQ
What are the official names of this protein?
Gametocyte-specific factor 1-like, Protein FAM112A.
What is the protein family that this protein belongs to?
Belongs to the UPF0224 (FAM112) family.
Protein: Y4LF_SINFN
Sequence: MPSVFFSYSHADEGLRDQLEKQLSMLKRQGVIETWHDRRIGAGEDIHRAIDDHINTDDIILLLVSADFIASDYCYDIEMQRAMERHHSGEAIVIPIILRACDWHHAPFGKLNAVPRDGKPITQWPDIDEAFLQVAKAVREAAGRVTRTASAPPARAAAAATPAASPAPQSLGPRSSNLRLAKSFTQRDKDQFRHDTFEYIARFFENSLKELGERNAGFEGVFRRVDANRFFATIYRDGKDVSRGTAYLGGETWGRGINYVHGETTSSNSSNESLNVEADDQTLFLTSMGMASFGRDRDQKLSQEGAAELLWAILIAPLQGTRY
What are the official names of this protein?
Uncharacterized protein y4lF.
Protein: Y4990_ARATH
Sequence: MLRSRRSRSRHGAQACAVMSAVLLLASVSLLYTRLSLFSSHSPNHLRSGSSEDTVLFPDSVLVSDSDVETTGGGGRGSTTSTEDRIDEHDDAIEDDGVSNEEDENQDAEQEQEVDLNRNKAASSSGFYFDHVNGVIRRAFNKRSIDEWDYDYTGFSIDSDSSGDKSSRAAFGSDDVPLDESIRRKIVEVTSVEDALLLKSGKKVSPLRQGWGDWFDKKGDFLRRDRMFKSNIETLNPLNNPMLQDPDSVGNTGLTRGDKVVQKWRLNQIKRNPFMAKKPLSVVSEKKEPNEFRLLSSVGEIKRGERKTLDNDEKIEREEQKNVESERKHDEVTEHMYADGTKWGYYPGIEPSLSFSDFMDSFFRKEKCSMRVFMVWNSPGWMFSVRHQRGLESLLSQHRDACVVVFSETVELDFFRNSFVKDSYKVAVAMPNLDELLQDTPTHVFASVWFDWRKTKFYPTHYSELVRLAALYKYGGVYLDSDVIVLGSLSSLRNTIGMEDQVAGESLNGAVMSFEKKSPFLLECLNEYYLTYDDKCLRCNGADLLTRVAKRFLNGKNRRMNQQELNIRPSSVFFPINSQQITNYFAYPAIEDERSQQDESFKKILNESLTFHFWNSVTSSLIPEPESLVAKFLDHSCIRCSDVL
What are the official names of this protein?
Uncharacterized protein At4g19900.
Protein: KTHY_PYRHO
Sequence: MRGYFIVLEGIDGSGKTTQAKLLAEWFEDKGYEVLLTKEPTDSELGKLIRRIILEESVIDGSKISYEAEALLFAADRAEHVKKIILPALSEGKVVICDRYFYSSLAYQWARGLDLNWLIQVNSFAPRPDLAILLDLPVKESLRRIKLRGTLTEFDKIVELQRKVRHNYLKLAEMFPEMRIVNALSSIEDIHSDIVALVKHELLGL
What are the official names of this protein?
Probable thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RS19_YERPA
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPIRTWSRRSTVFPNMIGLTIAVHNGRQHVPVFVSDEMVGHKLGEFAPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: HUTI_STAAS
Sequence: MNDLIINHIAELILPRSTDKPLKGKELDELNVVKNGTVVIKDGKIVYAGTHTDDYDATETIDASGKVVSPALVDAHTHLTFGGSREHEMSLKRQGKSYLEILEMGGGILSTVNATRETSEDDLFKKAEHDLLTMIKHGVLAVESKSGYGLDRENELKQLKVSNRLAEKYDLDMKHTFLGPHAVPKEASSNEAFLEEMIALLPEVKQYADFADIFCETGVFTIEQSQHYMQKAKEAGFKVKIHADEIDPLGGLELAIDEQAISADHLVASSDKGKEKLRNSDTVAVLLPATTFYLGKEDYADARGMLDNNGAIALATDYNPGSSVTNNLQLVMAIAALKLKLSPNEVWNAVTVNAAKAIDINAGTINTGDKANLVIWDAPNHEYIPYHFGINHAEKVIKDGKVIVDNTLSFKA
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_RHOPA
Sequence: MTDLTSLTLAEARDGLANKSFTAVELTDAHLAAIEAARVLNAYVLETPDQARQMAKAADAQIAKGEGGPLAGLPLGIKDLFATKGERTTACSKILGDFKPTYESTVTTQLWRDGAVLLGKLNNDEFAMGSSNETSCFGPVINPWRRAGSDAKLVPGGSSGGSAAAVAAGLCLGATATDTGGSIRQPAAFTGTVGIKPTYGRCSRWGIVAFASSLDQAGPIARTVRDSAILLRSMAGHDPKDTTSVDRPVPNYEAAVGGSVKGMKIGIPKEYRLDGMPAEIEKLWSQGAEWLKAAGAELVEVSLPHTKYALPAYYIVAPAEASSNLARYDGVRYGARVNGRNIIEMYENTRAAGFGAEVKRRIMIGTYVLSAGYYDAYYLRAQKVRTLIKRDFEQCFDQGVSAILTPATPSAAFGIGEKGGADPVEMYLNDIFTVTVNMAGLPGIAVPAGSDSQGLPLGLQLIGRPFDEDTLFSLGEVIEQAAGRFTPAKWWA
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: FDHD_MYCTU
Sequence: MGYATAHRRVRHLSADQVITRPETLAVEEPLEIRVNGTPVTVTMRTPGSDFELVQGFLLAEGVVAHREDVLTVSYCGRRVEGNATGASTYNVLDVALAPGVKPPDVDVTRTFYTTSSCGVCGKASLQAVSQVSRFAPGGDPATVAADTLKAMPDQLRRAQKVFARTGGLHAAALFGVDGAMLAVREDIGRHNAVDKVIGWAFERDRIPLGASVLLVSGRASFELTQKALMAGIPVLAAVSAPSSLAVSLADASGITLVAFLRGDSMNVYTRADRIT
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADB_CAUVC
Sequence: MTQYRITFEGPVILGAGLAGLTAALSATTGAAKTALVLSPTPLASGCSSAWAQGGMAAALSGDDSPALHAADTIAAGAGLCDPQAVDLLTREGPQAVRDLAALGAPFDRKADDGFVLSLEAAHSAARVARVGGDGAGAAIMAAVIAAVRATPGIEVRENARARRLLQDANGRVVGVLADVDGALVEIRSTAVILATGGVGGLYAVTTTPAQVRGEGLGLAALAGAMIADPEFVQFHPTAIDIGRDPAPLATEALRGEGAILRNADGKAFMADYHPAKELAPRDVVARALHAERAAGRGAFLDATAAVGAHFPHEFPAVFEACMSAGIDPRRQMIPVTPAVHYHMGGVATDLDGRASLPGLYAAGECASTGVQGANRLASNSLLEAAVFGARAGRAAAAEGATGGPPVSLEPLPDLPDAALQGLRKAMSRDAGVIRDADGLTRLLGEIETLEAGHGQGPILVAARLIVTAALAREESRGGHCRIDFPATDPVGVRTFVTLDGREPGLRYAAE
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GBRP_HUMAN
Sequence: MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMYF
What is the function of this protein?
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.  In the uterus, the function of the receptor appears to be related to tissue contractility.  The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit pi, GABA(A) receptor subunit pi.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: HBA_CEBCA
Sequence: VLSPADKTNVKTAWGKVGAHAGDYGADALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALSNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHHPADFTPAVHASLDKFLASVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: GRB10_RAT
Sequence: MNNDINSSVESLNSACNMQSDTDTVPLLENGQSASNQPSASSSRGQPQASPRQKMQRSQPVHIQPLRRLQEEDQQLRTSSLPAIPNPFPELAGGAPGSPPSVAPSSLPPPPSQPPAKHFPPGFQLAKLTRPGLWTKTTARFSKRQPKNQCQTDTANAVSRIPTSQMEKLRLRKDVKVFSEDGTSKVVEILTDMTARDLCQLLVYKSHCVDDNSWTLVEHHPQLGLERCLEDHEIVVQVESTMPSESKFLFRKNYAKYEFFKNPVNFFPDQMVTWCQQSNGGQAQLLQNFLNSSSCPEIQGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTSKEPRHLQLLADLEESSIFYLIAGKKQYNAPNEHGMCIKPNKAKIEMKELRLLCAEDEQIRTCWMTAFRLLKYGMLLYQNYRIPQQRKGLAPPFNAPMRSVSENSLVAMDFSGQIGRVIDNPAEAQSAALEEGHAWRKRSTRMNILSSQSPLHPSTLNSVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHQQKIRNFQILPCEDDGQTFFTLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
What is the function of this protein?
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways.  Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors.  The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation.  Delays and reduces AKT1 phosphorylation in response to insulin stimulation.  Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation.  Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways.  A similar role in the mediation of ubiquitination has also been suggested with INSR.  Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6.  Positive regulator of the KDR/VEGFR-2 signaling pathway.  May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 (By similarity).
What are the official names of this protein?
Growth factor receptor-bound protein 10, GRB10 adapter protein.
What is the protein family that this protein belongs to?
Belongs to the GRB7/10/14 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity).
Protein: GLMS_STRP8
Sequence: MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELDLSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLATTRNAFYIGRGNDYYVAMEAALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFJD_BACSU
Sequence: MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKYYLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKKIEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAKSNWIGQFTDIQRSAYLKEFENHPKL
What are the official names of this protein?
Uncharacterized lipoprotein YfjD.
What is the protein family that this protein belongs to?
To B.subtilis YfjE.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: APEL_HUMAN
Sequence: MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
What is the function of this protein?
(Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection (PubMed:11090199).  Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR (PubMed:11090199).  Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives (PubMed:11090199).
What are the official names of this protein?
Apelin, APJ endogenous ligand.
What is the protein family that this protein belongs to?
Belongs to the apelin family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Note=Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk.
Protein: ZNF30_HUMAN
Sequence: MAHKYVGLQYHGSVTFEDVAIAFSQQEWESLDSSQRGLYRDVMLENYRNLVSMGHSRSKPHVIALLEQWKEPEVTVRKDGRRWCTDLQLEDDTIGCKEMPTSENCPSFALHQKISRQKPRECQEYGKTLCQDSKPVQHERIHSSEKPNRCKECGKNFSNGHQLTIHQRLHVGEKPYKYEKCGKAFISGSAFVKHGRIHTGEKPLKCKQCGKTISGSYQLTVHKSIHTGKKPYECGECGKAFLVYGKLTRHQSTHTGEKPFGCEECGKAFSTFSYLVQHQRIHTSEKPYECKECGKAFSTSSPLAKHQRIHTGEKPYECKECGKSFTVYGQLTRHQSIHTGEKPFECKECGKAFRLSSFLHAHQRIHAEIKPYGCKECGRTFSRASYLVQHGRLHTGEKPYECKECGKAFSTGSYLVQHQRIHTGEKPYECKECGKAFISRHQLTVHQRVHTGEKPYECKECGKAFRVHVHLTQHRKIHTDVKPYECKECGKTFSRASYLVQHSRIHTGKKPYECKECGKAFSSGSYLVQHQRIHTGEKPYECNKCGKAFTVYGQLIGHQSVHTGEKPFECKECGKAFRLNSFLTEHQRVHTGEKPFKCKKCGKTFRYSSALKVHLRKHMSVIP
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 30, Zinc finger protein KOX28.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECR_BRAHW
Sequence: MNNIQSLDKLTQIISRLPGIGTRTAMRLALYLFDCDDEYLKEFSDVLSSLHENIKLCQVCYSLSDNDICDICSNDKREHNKICIVESYPDMLAIEKTEEYNGVYHILGGLISPLKGIGISDIRIKELIERVNNNSIEEIMIAFSASLEADTTASYIYKTLKDNNFNGRITRITYGISLASDIENADSRSLARSILDRVDMN
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: HISZ_STAAR
Sequence: MNNSEQLIALKESETAFLKYFNKADYELVDFSLVEKLDWKQLNHEDLQQMGERNFWQHEHQIYALRNDFTDQLLRYYSMYPTAATKVAYTGLIIRNNEAAVQVGLENYAPSLANVQQSLKLFIQFIQQQLRDNVHFVVLGHYQLLDALLDKSLQTPDILSMIEERNLSGLVTYLSTEHPIVQILKENTQQQLNVLEHYIPNDHPALVELKIWERWLHTQGYKDIHLDITAQPPRSYYTGLFIQCHFAENESRVLTGGYYKGSIEGFGLGLTL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THI4_META3
Sequence: MDISKIDLKADEKAVTKSIFKATYEMWMDNLEVDVVIVGGGPSGLTAGRYLADAGVKVLILERHLSFGGGTWGGGMGCPYITVQSPADEILSEVGIKLEEGEDGLFVADSVEVPAKLGTGAIDAGAKVLTGIVVEDVILKEGKVSGVVINSYAINKAGLHIDPLTINAKYVIDATGHDASVACTLARKNEDLGLVIPGEKSLWADEGENGLLKYTKELFPGLFVCGMASNATHGGYRMGAVFGGMYISGKIVADMILEKLKNE
What is the function of this protein?
Involved in the biosynthesis of the thiazole moiety of thiamine.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
What are the official names of this protein?
Thiamine thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
Protein: PANB_XANP2
Sequence: MSSQADARRITAPQIQARKGGEPIVSLTSYHSHTARLLDRHVDVILVGDSLGMVMHGMETTVPVTVEMMIVHGRAVVRGTKRALIVVDLPFGSYEASHTEAFHTAARVLKETGAGAVKLEGGRRMAETVRFLVDRGVPVMGHVGLTPQAINTLGSFKARGRDDAEASIILDDARAIAEAGAFSIVLEAIAEPLARRITQEVAPPTIGIGGSPACDGQILVLEDMLGLGDRVPKFVKKYANLGPDIEKAVASYADEVRARTFPAAEHTYAPRLVEKPAKAS
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.