PharMolix/UniProtQA huggingface dataset:
Protein: RPC1_YEAST
Sequence: MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKANGALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQRRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFPEGYKAKSISTSAKEPSENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKDLVPKRCLFESLSNEAALKAN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  Forms the polymerase active center together with the second largest subunit.  A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III.  A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC1, RNA polymerase III subunit C1, DNA-directed RNA polymerase III largest subunit, RNA polymerase III subunit C160.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DDR2_MOUSE
Sequence: MIPIPRMPLVLLLLLLILGSAKAQVNPAICRYPLGMSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGSRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPTAVYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSESSMFNNNRSSSPSEQESNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPAQPNGPEGVPHYAEADIVNLQGVTGGNTYCVPAVTMDLLSGKDVAVEEFPRKLLAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSCSSDATVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQEIHLLLLQQGAE
What is the function of this protein?
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation.  Required for normal bone development.  Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2.  Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion.  Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
What are the official names of this protein?
Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: IF2_YERPG
Sequence: MTDVTVKSLAAEIQTPVDRLVQQFADAGIKKSDVDSVTQQEKEILLAHLNREHGSVPNKLTLQRKTRSTLNIPSTGGKSKSVQIEVRKKRTYVNTPEAEQAKAEEQAQREAEATAQKIAEEKAKREAEEQAKREAAEKAKRQAAEKEKVTNQQTDEKTKPAQTDKARREAEAAELKRSVEEETRRKVEEDAKRVAEEARKMAAENEGKWPEPVAEQTESADYHVTTSQHARAAEDENDAKVEGDRRSRTRGGKATKQKKGNKLSESKADREEARAVGRKGKRKPSTLQQSFNKPVVAVNRDVVIGETVTVAELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEIGHKVILRRENELEEALMSDRDIGVEAAAEHRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAANVPVVVAVNKIDKPEADPDRVKTELSQYGIQPEEWGGESQFINVSAKAGIGIDELLNAILLQAEVLELKAVRTGMANGVVIESFLDKGRGPVATVLVQQGTLNKGDIVLCGFEYGRVRAMRDELGRDITSAGPSIPVEILGLSSVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVSELNIVIKSDVQGSCEAICDSLEKLSTDEVKVRIVGSGVGGITETDATLAAASGAIILGFNVRADASARRVVETEGLDLRYYSVIYSLIDEVKQAMSGMLAPEYKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVIKRNNPIRVLRDNVVIYEGELESLRRFKDDVSEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIKRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_PELUB
Sequence: MEIAVLGLGCFWGPEIKFSKLEGVIKTEVGYCGGDSKTVTYKEVCTCNTNHAEVVKLDFDPKIISYEKILNFFFEIHDPTTLNSQGPDFGTQYRSEIFYLSDRQKEIAESVIKKVNLKLSGNVVTKSSLLKNYCPAEEYHQRYLEKR
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: M2_I34A1
Sequence: MSLLTEVETPIRNEWGCRCNGSSDPLAIAANIIGILHLILWILDRLFFKCIYRRFKYGLKGGPSTEGVPKSMREEYRKEQQSAVDADDGHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: HCAD_ECOBW
Sequence: MKEKTIIIVGGGQAAAMAAASLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQQVLPANWWQENNVHLHSGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDALGERCFTLRHAGDAARLREVLQPERSVVIIGAGTIGLELAASATQRRCKVTVIELAATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHVVDGEKVELTLQSGETLQADVVIYGIGISANEQLAREANLDTANGIVIDEACRTCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQIAAAAMLGLPLPLLPPPWFWSDQYSDNLQFIGDMRGDDWLCRGNPETQKAIWFNLQNGVLIGAVTLNQGREIRPIRKWIQSGKTFDAKLLIDENIALKSL
What is the function of this protein?
Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
What are the official names of this protein?
3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family.
Protein: YNF8_KLULA
Sequence: MDLEYYEASAVVLEERALPALTTSTEETTAKQTSTNTDDDKTTSTSTSTSTGTSSKNTKLPSLTTKTTDGSTLTTSTGTSSTETASYTTPVMELPSAKGNPNIWSSNKPTGTVFIAVGSAAGFIFLALLVWFIINTWMSYSQAKQLKKFNNMEKQFQNPFIDDIDFSSGGGYYKADEDISTYKDTPVPTKNGGNNSFTPYKRASHSMIRLLGGSTDDGFGGGTPSSIGNTNLGSMNPLERVDAIDAANTGVRKSLYISPTMEVMNQQRRSTLFNNLNQSAVSIDTPEMMEPTRTVSPERRTYKHEKSKSSLSKLVDSTIDLTASTTLDNQKRQGRSKGHNKSSSITPSVYLDNMLEDNS
What are the official names of this protein?
Vacuolar membrane protein KLLA0F03465g.
What is the protein family that this protein belongs to?
Belongs to the PRM5 family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass membrane protein.
Protein: COX10_NEUCR
Sequence: MSSSTESLPGTLRRTLTTSRAPAATSSQRLKAGYFVSNAFLPRVKANGIHDSASSQRSTTVASTTSTTADAADGSSSTTQPTTAADLPPVDNTLLPHRRRQAQRKAAAAAAAAAANGETPTPLINPDAPTADLAPDASSQLAAAAASAPADSLKRRLSSLLSLSKPRLTVLVVLSAMVPYALYPVPSFLTSSALDTSLAPSLSPLTLLFLTTGTTLCSASANALNMLYEPDTDSKMTRTRTRPLVRRLLTTKAAVLFAVGCGLAGTLALYFGVNPTVSFLGAANIALYAGAYTPLKRISAVNTWVGAIVGGIPPLMGWAAAAGESATGDGTWRELLFASDGSSLGGWLFAGLLFAWQFPHFMPLSWGIRHEYKAAGLRMLAWTNPARNGRVALRYSLAFIPLCVGLSATGVTEWSFAVTSLPVNAWLVWEAIKFWRLEGHKGSARGLFWASVWHLPVIMVLALAQKKGMWGRVWRSVFGEPEEEEGEWVYEDEDEEEGGGVGEVVKGVVKK
What is the function of this protein?
Converts protoheme IX and farnesyl diphosphate to heme O.
What are the official names of this protein?
Protoheme IX farnesyltransferase, mitochondrial, Heme O synthase, Protoheme farnesyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: NDUB6_PIG
Sequence: MSGYTPDEKLRLQQLRELRRRWLKDQELSPREPLLPPRRVWPMEQFWNKFLQDGAPWKNVIYKTYRHSIFAVTHVLIPVWIIHYYLKYHVTAKPYTVVERKPRIFPGDTILXTGEVIPLIEGFPXQPS
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6, Complex I-B17, CI-B17, NADH-ubiquinone oxidoreductase B17 subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFB6 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: Y580_RICFE
Sequence: MMSNYNKNNLFAKLAYGDLSEVQALLKSGVNIDEHKNERGETALYNTLFTGYMDRAAFLLKHKASPNIPDNSGQTILYLLVMNNSIDKMKFLFENTTNIDLEIKSFCGHSPLHAATFNENIEAMELLLKKGADINSKDSFGASALHGTIYNNKLKAAELLLNHGADVNAKDNYEDTILHNIIGTNNIEAAKFLLQNGADVNIENNNNFTPLDRAILGQHKELAELFLKSGATIKIGNTMDFKILSEKLLDMNIDKELVFKSLLISNIDDQTKFQLLSDFNFKADIHHKIGLLLSLTLNCIFSAYK
What are the official names of this protein?
Putative ankyrin repeat protein RF_0580.
Protein: MSD3_AMABI
Sequence: MSDINTARLPFFQPPEFRPPCVGDDIEMVLTRGE
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:18025465).
What are the official names of this protein?
MSDIN-like toxin proprotein 3.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: IGG1_HUMAN
Sequence: QVQLVQSGGGVVQPGRSLRLSCAASGFTFSRYTIHWVRQAPGKGLEWVAVMSYNGNNKHYADSVNGRFTISRNDSKNTLYLNMNSLRPEDTAVYYCARIRDTAMFFAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
What is the function of this protein?
Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin gamma-1 heavy chain, Immunoglobulin gamma-1 heavy chain NIE.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: SYFA_NITMU
Sequence: MTHLDHLLTEAIELFNRTEDLAELEQVKARYLGRHGQLTELLKGLGKIPPEERPAAGSRINQAKESLEAALSRRREAIQEKKLEEQLIEEKLDVTLSGRGTGMGGLHPITLALERIQSLFHSVGFTVASGPEIETDFYNFTALNIPESHPARAMHDTFYVDDENGGASEHLLRTHTSPVQIRYMESNPPPLKVIAPGRVYRCDSDLTHTPMFHQVEGLWIDESANFSALKGILSDFMQHFFERDDLPVRFRPSFFPFTEPSAEMDIGCVMCKTGCRVCSYTGWLEVLGCGMVHPNVFKHVNIDSQKYVGFAFGLGVERLAMLRYGVNDLRLFFENDLRFLKQFN
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BORG2_MOUSE
Sequence: MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQGNYELLPGNQEKAHSGQFPGHNDFFRANSTSDSMFTETPSPVLKNAISLPTIGGSQALMLPLLSPVTFHSKQESFGRPKLPRLSCEPVMEEKVQEQSSLLENGAVHQGDTSWGSSGSGSQSSQGRDSHSSSLSEQSSDWPADDMFEHPASCELVKSKTKSEESFSDLTGSLLSLQLDLGPSLLDEVLNVMDKNK
What is the function of this protein?
Probably involved in the organization of the actin cytoskeleton.  May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes.  Induces pseudopodia formation in fibroblasts (By similarity).
What are the official names of this protein?
Cdc42 effector protein 3, Binder of Rho GTPases 2.
What is the protein family that this protein belongs to?
Belongs to the BORG/CEP family.
What are the subcellular locations of this protein?
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Protein: TLR12_MOUSE
Sequence: MGRYWLLPGLLLSLPLVTGWSTSNCLVTEGSRLPLVSRYFTFCRHSKLSFLAACLSVSNLTQTLEVVPRTVEGLCLGGTVSTLLPDAFSAFPGLKVLALSLHLTQLLPGALRGLGQLQSLSFFDSPLRRSLFLPPDAFSDLISLQRLHISGPCLDKKAGIRLPPGLQWLGVTLSCIQDVGELAGMFPDLVQGSSSRVSWTLQKLDLSSNWKLKMASPGSLQGLQVEILDLTRTPLDAVWLKGLGLQKLDVLYAQTATAELAAEAVAHFELQGLIVKESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQSAVLCMNETGDVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRYNQLLSLEGYLFQELQQLETLKLDGNPLLHLGKNWLAALPALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLKLPALPAPAVLFLPMYLTSLELHIASGTTEHWTLSPAIFPSLETLTISGGGLKLKLGSQNASGVFPALQKLSLLKNSLDAFCSQGTSNLFLWQLPKLQSLRVWGAGNSSRPCLITGLPSLRELKLASLQSITQPRSVQLEELVGDLPQLQALVLSSTGLKSLSAAAFQRLHSLQVLVLEYEKDLMLQDSLREYSPQMPHYIYILESNLACHCANAWMEPWVKRSTKTYIYIRDNRLCPGQDRLSARGSLPSFLWDHCPQTLELKLFLASSALVFMLIALPLLQEARNSWIPYLQALFRVWLQGLRGKGDKGKRFLFDVFVSHCRQDQGWVIEELLPALEGFLPAGLGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLELRLATSLLLAAPSPPVLLLVFLEPISRHQLPGYHRLARLLRRGDYCLWPEEEERKSGFWTWLRSRLG
What is the function of this protein?
Participates in the innate immune response to microbial agents.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Plays a role in preventing infection of internal organs of the urogenital system.
What are the official names of this protein?
Toll-like receptor 12, Toll-like receptor 11.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RS28A_YEAST
Sequence: MDNKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDTSRTIVRNVKGPVRENDILVLMESEREARRLR
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
40S ribosomal protein S28-A, S33, Small ribosomal subunit protein eS28-A, YS27.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS28 family.
Protein: COT1_YEAST
Sequence: MKLGSKQVKIISLLLLDTVFFGIEITTGYLSHSLALIADSFHMLNDIISLVVALWAVNVAKNRNPDSTYTYGWKRAEILGALINAVFLIALCVSILIEALQRIIAPPVIENPKFVLYVGVAGLISNTVGLFLFHDNDQEHGHGHGHSHGGIFADHEMHMPSSHTHTHAHVDGIENTTPMDSTDNISEIMPNAIVDSFMNENTRLLTPENASKTPSYSTSSHTIASGGNYTEHNKRKRSLNMHGVFLHVLGDALGNIGVMLSAFFIWKTDYSWKYYTDPLVSLIITGIIFSSALPLSCKASKILLQATPSTLSGDQVEGDLLKIPGIIAIHDFHIWNLTESIFIASLHIQLDISPEQFTDLAKIVRSKLHRYGIHSATLQPEFITREVTSTERAGDSQGDHLQNDPLSLRPKTYGTGISGSTCLIDDAANCNTADCLEDH
What is the function of this protein?
Vacuolar transporter that regulates zinc homeostasis by mediating zinc transport and storage into the vacuole (PubMed:9712830, PubMed:10856230, PubMed:12556516).  Plays a role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm (PubMed:12556516).  May also participate in the regulation of cobalt levels under normal physiological conditions and may be important in the supply of metal that is required for metalloenzyme or cofactor synthesis (PubMed:1508175, PubMed:18930916).  Involved in the resistance to cobalt and rhodium ions (PubMed:1508175).
What are the official names of this protein?
Vacuolar zinc transporter COT1, Cobalt toxicity protein 1.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Note=Another possibility exists that it is associated with another unidentified membrane that has been enriched in the mitochondrial membrane fractions.
Protein: TMUB1_XENLA
Sequence: MALIEGVGDEVTVLFALVLFFMVLMLAWVSTHTTERAPTHWIRPEPAQGGASSNSQRDFHPGPSQTLTNADPNSETVDSSDSTQSSREFQNAGATPHSEVAFSSSGSTVSTGGSVEYTGAAADSPPDGESHPNFTVSSRDPQAGASSSLRYRGLGDGTTAQSAEEAGTIHLRLKFLNDTERLVTVRLSDTIMYIKRTYFPGQELRVRLIFQGQLLRDDSQTVSSLQLRDGSVLHCHISQHASVPGVGADQANVPLNVGNLLVPLLFLIVMLLWYCQFQYPSLFTGTATACLGGFTLLISAIAFSSYHR
What is the function of this protein?
May contribute to the regulation of translation during cell-cycle progression.  May contribute to the regulation of cell proliferation (By similarity).  The membrane form is involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR.  May be involved in centrosome assembly.
What are the official names of this protein?
Transmembrane and ubiquitin-like domain-containing protein 1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cytoplasm. Nucleus.
Protein: UREG_RHOCA
Sequence: MTNGPLRVGIGGPVGAGKTTLTEQLCRALAGRLSMAVVTNDIYTREDAEALMRAQVLPADRIRGVETGGCPHTAIREDASINLAAIADLTRAHPDLELILIESGGDNLAATFSPELADLTIYVIDTAAGQDIPRKRGPGVTRSDLLVVNKTDLAPHVGVDPVLLEADTQRARGPRPYVMAQLRHGVGIDEIVAFLIREGGLEQASAPA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COA4_YEAST
Sequence: MSETGETSEYYKQALEEYKEVQEDEDPDVWDTRISKTGCYVENLALQLCHAETGDWRQCFNEMALFRKCWEKNGNRERVSTVDVDGTTSKDSEKKK
What is the function of this protein?
Involved in cytochrome c oxidase assembly or stability.
What are the official names of this protein?
Cytochrome oxidase assembly factor 4, Cx9C motif-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the COA4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion intermembrane space. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery.
Protein: RL14_PYRAB
Sequence: MAKKGAGATRGITPVRPTRAIPVGAYLTVADNSGAKVIQVIGVVEYHGTRRRLASAGVGDMVVATVKKGRPDMRHQVVRAVIIRQRKEYRRLDGMRIKFEDNAAVIVTPEGVPRGTEIRGPVAREAAERWVRIGSIASIIV
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: GLGC_DEIGD
Sequence: MKPRVLGMILAGGQGSRLAPLTLKRSKPAVPFGGKYRIIDFAINNFINSGVFSIYVLTQYKAQSLTEHIQRGWRFGTFLQDYFITLVPAQMYRYEELGAVWYRGTADAVYQNLHLIDNFNADYVAIFSGDHIYKMNVEHMLQAHMDARADVTIAAYPMPRTRAHQFGVMQVDDRWRVTEFLEKPQDPPGLPGDPDTSLTSMGNYIFSRRALEELLHTSISGEGEGFDFGHNVLPRALADGYHVQAYDFHRNPIPGQSSPNLYWRDVGTLDAYFEASMDLVSVNPEFDIYNPQWPLRTSSEFSPPAKFVHEAEGRKGQAFNSLLAGGVIISGGTVRDSILSRNVRTHSYSLVESCVLFDNVEVGRHSHLRRVIVDKDVIIPPGTRIGLDHEEDRGRGFTVTNNGIVVVPKSYTF
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.