PharMolix/UniProtQA huggingface dataset:
Protein: DPCKG_METST
Sequence: MLTLPKYLRSELKKPLGQLYKSIDIIEEKLHQQLSEDKLIISIGDATTKNLIKLNIQPQICIVDNKIEREPVEHKLTHTDNLVHVNNPAGCITDELVKICIDSINTATSNNPVIIEVKGEEDLAVLPCILNAPKDTFILYGQPKEGVVLVCVNEAFNKAKHFYKQLNKE
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
What are the official names of this protein?
GTP-dependent dephospho-CoA kinase, Dephospho-coenzyme A kinase, DPCK.
What is the protein family that this protein belongs to?
Belongs to the GTP-dependent DPCK family.
Protein: RFC_SALMU
Sequence: MLPFPPGAILRDVLNVFFVALVLVRFVIDRKKTYFPLVFTIFSWSAVILWVIALTIFSPDKIQAIMGGRSYILFPAVFIALVILKVSYPQSLNIEKIVCYIIFLMFMVATISIIDVLMNGEFIKLLGYDEHYAGEQLNLINSYDGMVRATGGFSDALNFGYMLTLGVLLCMECFSQGYKRLLMLIISFVLFIAICMSLTRGAILVAALIYALYIISNRKMLFCGITLFVIIIPVLAISTNIFDNYTEILIGRFTDSSQASRGSTQGRIDMAINSLNFLSEHPSGIGLGTQGSGNMLSVKDNRLNTDNYFFWIALETGIIGLIINIIYLASQFYSSTLLNRIYGSHCSNMHYRLYFLFGSIYFISAALSSAPSSSTFSIYYWTVLALIPFLKLTNRRCTR
What is the function of this protein?
May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS.
What are the official names of this protein?
O-antigen polymerase.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UACA_CANLF
Sequence: MPSSLLLATRNQILSMMNCWFSCAPKNRHAADWNKYDDRLMKAAERGDVEKVSSILAKKGINPGKLDVEGRSAFHVVASKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMCRPAICQLLIDRGAEINSRDKQNRTALMLGCEYGCKDAVEVLLKNGADVSLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLPYMLDEVNVKSSQREHRNIQELEIENEDLKDRLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEKEKLKSLLVAKEKQHEESLRTIESLKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMTCTSPGVPAHMQSRSMLRPLELSLPNQTSYSENDLLKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALGLECERIKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAAIGNHRLMEELKDQLKDMKAKYEGASAEVGKLRNQIKQNELLVEQFRRDEGKLVEENKRLQKELSMCETERDKKGRRVAEVEGQVKELLAKLTLSVPTEKFESMKSLLSSEVNEKVKKIGETEREYEKSLTEIRQLRRELENCKAKLAQHVKPEEHEQLKSRLEQRAGELAKKVTELTSKNQVLQRDVEKVYLDNKLLNQQVHNLTSEIKSHYVPLQVSEEMKKSHDVTVEELKKQLLDVTQKCADKQLEMEKLLLENDSLSKNVSRLETVFVPPEKHQKEVTALKSSVADLKRQLLELNKKCGEDREKINALVSENTSLKKTLSNQYVPAKTHEEVKTALSGTLDKTNRELLDAKKKWEDLNQEFVKTKDENEILKRNLENTQSQIKAEYISLREHEEKMSAINQNMKSVQDNSAEILANYRKGQEEIVTLHAEIEAQKKELDTIQECIKLKYAPIISFEECERKFKATEKELKEQLSEQMQKYHVREEEAKKYKQENDKLKKEIFTLQKDLKDKNVLIENSHDMERALNRKAEELNKQLKDLLQKYSEIKTEKEKLVDDNARQTSELLAAQTLLQKQHVPLEQVETLKKSLNSTIEHLKEELKNKQKCYEKEQQTVAKLHQMLENQKNSSVPLGEHLRVKEAFEKEVGMIKASLREKEEESQNKTEEVSKLQSEVQDTKQALQKLETREVVDLSKYKATKSDLETQISNLNEKLANLNRKYEEACEEVLRAQRKQLSAKDEKELLHFSIEQEIKDQQERCDKSLTTITELQKRIQESAKQIEAKDNKITELLNDVERLKQALSGLSQLTSPSGSPSKRQSQLIDTLQHQVKSLQQQLADTDRQHQEVIAIYRTHLLSAAQGHMDEDVQAALLQIIQMRQGLVC
What is the function of this protein?
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility.  Interaction with ARF6 may modulate cell shape and motility after injury.  May be involved in multiple neurite formation (By similarity).
What are the official names of this protein?
Uveal autoantigen with coiled-coil domains and ankyrin repeats.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Expressed diffusely in cytoplasm.
Protein: Y4948_BACMK
Sequence: MTENNDIKMVIITGMSGAGKTVALQSFEDLGYFCVDNLPPMLLPKFIELMADSKGKMNKVALGIDLRGREFFEYLWGALDDLSERTWIIPHILFLDAKDSTLVTRYKETRRSHPLAPTGLPLKGIEAERGLLTDMKARANIVLDTSDLKPKELREKIVHLFSTETEQAFRVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIPHMKPLTGLDEEVSSYVLKFNETHKFLEKLTDLITFMLPHYKREGKSQLVIAIGCTGGQHRSVTLTEYLGKHLKPEYSVHVSHRDVEKRKGH
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein BcerKBAB4_4948.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: KCNH4_HUMAN
Sequence: MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH
What is the function of this protein?
Pore-forming (alpha) subunit of voltage-gated potassium channel.  Elicits an outward current, but shows no inactivation.  Channel properties may be modulated by cAMP and subunit assembly.
What are the official names of this protein?
Potassium voltage-gated channel subfamily H member 4, Brain-specific eag-like channel 2, BEC2, Ether-a-go-go-like potassium channel 1, ELK channel 1, ELK1, Voltage-gated potassium channel subunit Kv12.3.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LEUC_YEAST
Sequence: MVYTPSKGPRTLYDKVFDAHVVHQDENGSFLLYIDRHLVHEVTSPQAFEGLENAGRKVRRVDCTLATVDHNIPTESRKNFKSLDTFIKQTDSRLQVKTLENNVKQFGVPYFGMSDARQGIVHTIGPEEGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRITVNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEAGARAGMIKPDETTFQYTKGRPLAPKGAEWEKAVAYWKTLKTDEGAKFDHEINIEAVDVIPTITWGTSPQDALPITGSVPDPKNVTDPIKKSGMERALAYMGLEPNTPLKSIKVDKVFIGSCTNGRIEDLRSAAAVVRGQKLASNIKLAMVVPGSGLVKKQAEAEGLDKIFQEAGFEWREAGCSICLGMNPDILDAYERCASTSNRNFEGRQGALSRTHLMSPAMAAAAGIAGHFVDIREFEYKDQDQSSPKVEVTSEDEKELESAAYDHAEPVQPEDAPQDIANDELKDIPVKSDDTPAKPSSSGMKPFLTLEGISAPLDKANVDTDAIIPKQFLKTIKRTGLKKGLFYEWRFRKDDQGKDQETDFVLNVEPWREAEILVVTGDNFGCGSSREHAPWALKDFGIKSIIAPSYGDIFYNNSFKNGLLPIRLDQQIIIDKLIPIANKGGKLCVDLPNQKILDSDGNVLVDHFEIEPFRKHCLVNGLDDIGITLQKEEYISRYEALRREKYSFLEGGSKLLKFDNVPKRKAVTTTFDKVHQDW
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: YG32_YEAST
Sequence: MADNSTSRFYTNLLIANYLKHNGLEDTLAAFIRETALPLSALEKSDSSNSNVGEIPLEDLQSVVEDRIYYKRRSFKDRFKTLSINDDLAPIDNAKYGIQPWNHSLKFSIDVKLNKSLPKDTLFISATFTEDSKYILLSSATGYLVIYDIEKATSKSFKINEKVKSIVKLYGPIGSSGYQYVCPMNGSFYLLNNDFELVNNAVWKIHARMITHIKICNVTESSWFVITSGMDNFLRLSLLEIKNGNTFLTKLSEIKLASNCTSLNVIANGDGNGQNSFSVFLTRAEYTHIACYSIIDAKNLVHSYNIALNNAEFSTYAFNIRDVMAVDYVHSNTKDTIGLSPSTMLVVATSHKPYMRLILVEIPMNTGHPKAMKLDKVQTYYDKILRNFATEIYQDDFSLPILGKLESSNGVLVGNDEGIYSVDLMTGDSRILNIPGEANSLHDRIKCMDISKDQMRMVAGTSTKSIYILNVIRNAQ
What are the official names of this protein?
Uncharacterized protein YGR117C.
Protein: KUP_POLAQ
Sequence: MSVSNPEFSESSILRPVEISRQTHPHKKGASIALMFAAIGIVFGDIGTSPLYALKECFSPDHGIPFSADAVYGVISMVFWAFAIVVSLKYVLFVMRANNHGEGGILALMALALRTAPNGSKRSLLIIMAGVFGACMFYGDAIITPAISVLSAVEGLEVISSDLTRFVLPITVLILVILFFIQKTGTEVVGKLFGPIMMVWFITIGLMGLHQVIQNPAIFAAVNPMFAIRFLIEHSLQGFIVLGAVFLVLTGAEALYADMGHFGIRPIRMGWFFIVMPCLLLNYFGQGAMFLANPETISNPFFLMVPEVFVFPLVILATAATVIASQAVISGAFSMTSQAILLGFVPRMKVRHTSDREIGQIYMPFVNWTLLFLVIVVVLAFKKSENLAAAYGIAVTTTMIVTTLLAAIVMRVVWRWNTILVTLVIGAFLTVDLAFLTANLLKIMEGGWFPLLLGAICFLFLMTWYQGRKLLRQNAVNNGIELKGFIDALMQHPPHRVEGTALFLTAHVDYVPVSFLHNLKHNHVLHERVFFLKVSIWDVPYVKDEERITLRDMGNGIYVVRAVYGFNETPDMGQIIELIEKSADLKFDMMNTSFFLSRDTIVSTEIPGMAMWRERLFCWMYQNAGRQSDFFKIPANRLVELGAKVEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOA_HORVU
Sequence: MVREEVAGSTQTLQWKCVESRVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGEIEGTCITRAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRDASICVKGPRYITAQDIILPPSVETVDTAQPIANLTEPIDFCIDLQIKRDRGYQTELRKNYQDGSYPIDAVSMPVRNVNYSIFSCGNGNEKHEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHAEEEGTSFEENKNRFTPPLFTFQKRLTNLKKNKKGIPLNCIFIDQLELTSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMEDRKHIWDTLEKHLPIDLLKNKLSF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: APT_PSEPW
Sequence: MHSEAFDLKALIRPVVDFPKPGVIFRDITPLFQSPRGLRYVADQFIERYVEAEFSHIGAMDARGFLIGSIIAHQLNKPLILFRKQGKLPADVLSEGYQTEYGEAFLEVHADSLCEGDSVLIFDDLIATGGTLLAAANLVRRTGAQVFEAAAIIDLPELDGSRRLQAAGVPTFCLTEFSLSEY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SALK6_KALTU
Sequence: MKTFNLPLLVALFYLFVSVARSQGPIDITKFGAKPNADATSALLAAWKEACAAAAPAKIVVPAGEFLLNAVKLQGPCKAPLTIEIAGNFKAPADVAQMKGEDTWVKIENVQGLTITCLPTGGTFDGQGQAAWKQNKCAQSGMCNSLPYNFRFNTLTNAQISGIKSLNSKLYHMGVMGCKNITLTGLTIDAPKDSLNTDGMHIGRSNGVHATNSKIGTGDDCISMGDGAVDVHVEGITCGPGHGISIGSMGKFANEAPNTGIFVKNCSFTDTDNGVRIKSWMNSFEASASDLHFEDITVTNVLNPVIIDQEYCPYNHCKEKTPSKVKLSKISFKNVHGAAKSAEVVKLLCSSAVPCDGVELADIDLTFPGGAAVSQCKNVKPIVTGKQNPVACGAPATPAAP
What is the function of this protein?
May function in depolymerizing pectin during pollen development, germination, and tube growth.  Acts as an exo-polygalacturonase.
What are the official names of this protein?
Probable galacturan 1,4-alpha-galacturonidase SALK6, Exopolygalacturonase SALK6, Pollen allergen Sal k 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall.
Protein: PALF_DEBHA
Sequence: MRRAVSKIIPNGPPRFLQSGSLLSGDTNFKYRIDFNSVDEFYISLADPHRSWLPGDEISGQIIFISKKDLANIVITLSLIGSVKINASSHSKLRPVKELLFHHTIKIYGDENSGNNNENGEEFSNGLFKGEHRFPFIVKLPNKRVFTSIDFGKGSIKYSLKAAVGNASSFANDSPAASPLSDSNNNNNNTTKNNFISKTKNLNFHNSVYTSEKIITLINPIDVSKLPRSKPKRLIIKDPRLSKKLSRTQSSTSTLNTVNTFNTLSSNNSDTTTNGEFHSNGNTPGNSASQSNSNSPLNGLDNARPQVIKVALEIPERGFLRGELIPTKLNINHSRKIQDLNGIIVTLVRVCRLSNGHENMVESFRKDLQQSVLPLYVDPNTFQSEINTNLRVPADAFPTISGCPLVSFQYFIEVLINLSGKSLILDSSNHHKPSISTDEANHSLLENPSNDLKYKFNFNSNASMNQNERSGFINTDKYKRMKKFLLLTTEVIIGTNRSNERSAYTSNERSNELLHDNLNSISPTSRKSSSVSGSNDSPLLFNQTGSTPPSQQGHQQPMSLNPLSEAIPANNFSTPPYFENQQDSPLNIADTPIPGYEEVSNNYHANSSLAPVQMPTHQHLSEKEQIRAHEASLLPSAPPLDDAEETETISPIDKNNEILENIEESGEEVNQLNNESNDSASSRHSQSFGFFTYQNSTSTTTPTNHESLEEEEEEEEDNLYHSNNLSNSHAEIDSESTDWVPNYETANHDILLENDHVSTGTNMHPGRNANSSARGPQQDNSS
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
What are the official names of this protein?
pH-response regulator protein palF/RIM8.
What is the protein family that this protein belongs to?
Belongs to the arrestin family. PalF/RIM8 subfamily.
Protein: UBE2O_MOUSE
Sequence: MADPAAPAPAQAQAAAAPTPAAAPAAAAPPPAPATDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGDDDGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGTNCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSIITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRIMSCTPDTQCPRDHSMEDPDKKGEARAGSEIGSASPEEQPDGSASPVEMQDEGSEELQETCEPLPPFLLKEGGDDGLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTGRKKSIPLSIKNLKRKHKRKKNKVTRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGALPKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSSSGASSDEWEDDSDSWETDNGLVDDEHPKIEELAAILPAEQPTAPEEDKGVVISEEAATAAIQGAVAMAAPVAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIAEEEKMEAVPDTERKEEKPEVQSPVKAEWPSETPVLCQQCGGRPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPDGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSVGGWRLVNRIESWLETHAMQERAQVMPNGALKDSSSLEPMAAAELSDSGREEPEDVGMAPGEASQGSDSEGGAQGPASASRDHTEQTETAPDASAPPSVRPKRRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLTQFRAALLEAGMPESTEDK
What is the function of this protein?
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins.  Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity.  Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis.  Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1.  Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location.  Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
What are the official names of this protein?
(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O, E2/E3 hybrid ubiquitin-protein ligase UBE2O, Ubiquitin carrier protein O, Ubiquitin-conjugating enzyme E2 O, Ubiquitin-conjugating enzyme E2 of 230 kDa, Ubiquitin-conjugating enzyme E2-230K, Ubiquitin-protein ligase O.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm.
Protein: CDC73_HUMAN
Sequence: MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF
What is the function of this protein?
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways.  May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.  Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.  PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.  PAF1C is required for transcription of Hox and Wnt target genes.  PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.  PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3).  PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription.  PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors.  In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription.  Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling.  Involved in polyadenylation of mRNA precursors.
What are the official names of this protein?
Parafibromin, Cell division cycle protein 73 homolog, Hyperparathyroidism 2 protein.
What is the protein family that this protein belongs to?
Belongs to the CDC73 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPX_BURCJ
Sequence: MADKKGSNSEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIDLCNEIIRDEAAAAGVEASLSRSDLPSPQEIRDILDQYVIGQERAKKILAVAVYNHYKRLKHLDKKDDVELSKSNILLIGPTGSGKTLLAQTLARLLNVPFVIADATTLTEAGYVGEDVENIIQKLLQNCNYEVDKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLVEGTMASVPPQGGRKHPNQDFIQVDTTNILFICGGAFDGLEKVITDRTEKTGIGFGATVKSKQERDAGEVLRETEPEDLIKFGLIPELIGRLPVVATLGKLDEAALMKILVEPKNALVKQYHKLFAMERVELEIRPGALQAVARKAIRRKTGARGLRSIIEQALLDVMYELPTMKGVSKVIIDENVIDGDGKPLLIYEDTPKVAGSN
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: GSA_FRAT1
Sequence: MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYIGSWGPMILGHCDDDVLEAIQCQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGTEATMSAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSGALSLGQPNSPGVPEDVVKDTLVASFNDMESIQALFEKYKDEIACIIIEPIAGNMNMIFPQDDFLAKLRAICDQNSSLLIFDEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAGTLSGNPIAMTAGIKTLEKISQPGFFDELGAKAQKLVDGLNEAAKAYDFNFHAKCLGGMFGLFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAPSAYEAGFISIAHSDEDIEKTIYLAKKFFQEN
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPAT5_MOUSE
Sequence: MSSKKNRKRQKEGAEGASPSLSAAPSRSGTSTPFAQPSPAAPGMLVVTNFLEKVDGKVPKTFQNSLVHLGLNTMKSANICIGRPVLLTSLDGKQEVYTAWPVAGFPGGKVGLSEMAQKNVGVRAGETIQVQPLLGAVLQAQEMDLALSDKDKEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRLCKLQVLQVKGTDGTTLGKLQSASGTDAQGMASEHSSMESSDVDLSFQLSQLDLKEPQSPSSQSTPCKPTNDRTVNKAGEVLLDVTQSPRDGSGLGLEESTGLKCSFDSSKEGNTQPVSEEKLLKPASAGTKSNTDTFYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAEIIAVCKEAALLALEENIKADCIMKRHFTQALSIVTPRIPESLRRFYEDYQEKSGLHTV
What is the function of this protein?
ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles.  Acts together with SPATA5L1, C1orf109 ortholog and CINP (By similarity).  May be involved in morphological and functional mitochondrial transformations during spermatogenesis (PubMed:10734318).
What are the official names of this protein?
Ribosome biogenesis protein SPATA5, Spermatogenesis-associated factor protein, Spermatogenesis-associated protein 5.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. AFG2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, spindle.
Protein: TRUA_CLOAB
Sequence: MKNVKLTLEYDGTNYCGWQKQKNVVTVQEEVEKIIGEITGEKIDVIGCSRTDSGVHAKAYTCNFKTNTVIPPEKFYLVLNSVLPDDIVALNSEEVPMDFHSRFDNKGKTYSYTILNRLQRAAIDRNYVYQYGHKLNCDLMREATKYILGTHDFTSFKSTGSKVKSNIRTIYEARIVEDENKVIFYVTGDGFLYNMVRIIVGTLLEVGEEKITPLNVKTIVESKDRTKAGRVVPAKGLCLEKVMY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: CINAL_DESDA
Sequence: MRAEIISVGTELLLGHTINTDAAHVGRALSALGMDLLQVHTVGDNAGRLEAALREALNCADVVITTGGLGPTDDDMTKETVARVLGAPLEEHKDSLRRLREYFGSRPIAANQLKQAWLPRGSTAFPNRAGTAPGCAVPGKPGQWVILLPGPPSELLPMLEDSVMPFLQRMGGAVIASFMVRTFGIGEGSAALRIADLTEGANPTVAPYASDAEMFVRVTAKAENAEAAEALAKPVVDAVRGRLGDVVYGVNVSGLEAVVVEQLRQHRRSLAIAESCTGGLLAKRITDQPGASEVFGYGLITYANEAKTRLLGVPEEQLACYGAVSPQVARSMAVGVRERYGADYGLGITGVAGPGGGTEEKPVGLVYVALSCSNAVWLRVLRPQGRYLGREWTRRLASSHALDMLRRHMAGLPVEAGWADGLPQD
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: CHEF2_HALS3
Sequence: MSESAIADFVSSFIPDTATHVEPVRGRVVMSKRRIVLAADDEKTTIPLNGVFDVQHETAPGDLARFFEDTVTIAYEHDEDRHVAVIEGGGSTVDRFVTLVFKALVHGTTVYAKHPARRGGRITDQPFEKGNLALSPGDLTITGDADTTIDLSTVSHFERVDREVNGSNKQLLSVRHMGSTGPITTELALSSGRKMNLLGRYIRLQYTHLKQELADVTLTSEEIEALVAIYSSGPNASLAAVLGVDASRVTMLLNDLIEKELVTDDDGIALTSLGRAAVSEHIEDVNL
What is the function of this protein?
Involved in taxis signal transduction.
What are the official names of this protein?
Taxis protein CheF2.
Protein: RPOC1_WELMI
Sequence: MIDSKKKHQKLKITLVSPEQIRAWSETILPNGKRVGEVTNPDTLDPTTKKPQRDGLYCERIFGPVKSGVCACEKKPGQKKKGFAFVDRKKKKDSNFCKYCEVELVDSRIRRYRMGYIKLACPVAHIWYIKRVPSYIPTLIGKKKSEVIDLVYCNLFITRPAANRPTILRFRGLLQDENLPSWIGILFPYISSWNFVEFQERELATGGNAIQKRLTGLDLRILLTHSYMEWKKLLRNYKIQRTQREKNKIQKRKNFLVRRIKFVKYLIQAKIKPEWMVLCLLPVLPPELRPIFVLGEQIIAESDLNKLYQKVLIRNKNLQSSFEMQGDPLYSTGKRDFMTFQKRLLQEAVDALLDNDRSGEPGEDLFNRPYKSFSDVIAGKEGRFRANLLGKRVDYSGRSVIVVGPSLALHQCGLPREMAIKLFQPFLIRNLIRRGVAPNIRAAKSLIQGRKPFIWKILQRVMLGHPVLLNRAPTLHKFGILAFQPILVKEHAIRLHPSVCTGFNADFDGDQMAVHVPLSIEAILESRLLMFSHTNLLSPSSGSPITIPTQDMLLGLYILTADKNQDISEFRYHPSKSKKKISSKKNPCFSNYDDVFIAYQQKRVQLNSPLWLRWRVADGGILTSVDREVPIEIQHEPFGTSQEIYEHYAIQKNRMGKISNIYIRTTVGRILFNREIEKAFLSFSKLLESPQTNPVF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HVM26_MOUSE
Sequence: MKMWLNWVFLLTLLHGIQCEVKVVESGGGLVQPGGSLRLSCATSGFTFSDFYMEWVRQTPGKRLEWIAASRSKAHDYRTEYSASVKGRFIVSRDTSQSVLYLQMNALRAEDTATYYCTRDADYGNSYFGYFDVWGAGTTVTVSS
What are the official names of this protein?
Ig heavy chain V region M167.