PharMolix/UniProtQA huggingface dataset:
Protein: TATA_RHOJR
Sequence: MGAMSPWHWAIVALVVIILFGSKKLPDAARGLGRSLRIFKSEVKEMQNDNSTPAPTAQQSAPAELPVADTTTAPVTPPAPVQPQHTEPKSA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: QUEC_ECOLI
Sequence: MKRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYGQRHRAEIDVARELALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPEADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVSLGMAKDIRFETPLMWIDKAETWALADYYGKLDLVRNETLTCYNGFKGDGCGHCAACNLRANGLNHYLADKPTVMAAMKQKTGLR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: ASTE_VIBVY
Sequence: MTNSLFRQSFLSDTLNMQQSVEAKATTLSNGVRLQLHQRGVLEVIPANNSAETKNIILSSGIHGDETAPMELIDKIVHDIETGFQDVQARCLFIIAHPEATNAHTRFIEENLNRLFDEKEHQPSKELVIADQLKLLVKAFFDNTPVESRWHLDLHCAIRASKHYSFAISPKTRHPTRSKALVDFVNHSHVEALLLSNSPSSTFSWFSAEYYSAQALTMELGRVARIGENDLSRFTALDLTMRDLIAEVTPEHLPKPAITYRVSRTIVRLHQDFDFRFDDQVENFTSFMHGEVFGHDGDKPLMAKNDNEAIVFPNRNVAIGQRAALMVCEIKARFEDDQLVYD
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: AROK_GEOMG
Sequence: MATSTISAPSSVRNVILTGFMGTGKSSVGRLLAHRLGFRYCDLDALIVEGEGVSINEIFARHGEPHFRALETEAVRSVSREERCVVSTGGGAVISPENRCLLRKAGVVVNLTATVEEVCRRLREETDRPLLKDDRSGERIAAMMAEREQFYADAELRIDTTGKSVEDVVAEITGYLEGR
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUT11_TAKRU
Sequence: MLLQMAGRGKMVPCVCLGLLGVLCWVWVSFASFPDEQLSLGAMDAVERAAFQPQSALSEMEFASIGSYRGPGNLDHRSNKELPILLWWSAGLFPHFPGDTERIDCARSSCLATSNRKVQLYKRTASIIFYGTDFRAYEAPLPRLRHQTWALFHEESPMNNYLLSHGPGIRLFNYTATFRRESDYPLTLQWLPSLEYLLTPVPVPLEEKNRLRREGLAPVLYMQSHCDVPSDRDRYVQELMKYIQVDSYGKCLNNKPLAGNLEDTSTATGEEQTFMSFVARYKFHLALENGLCPDYMTEKLWRPLHQGCVPVYRGSSVVADWMPNERSAIIIDEFPSPQALAEYLLHLDENDDEYRKYLEFKSPKRITNARLLEALERREWGVNDMSKPNYLNGFECYVCDQENARLAAERAHRKAPKTNKPPEWKMANNSHMGCPLPSPGYGQVHHLPADDGWLQTWPQDYWQSLDQAEGLESLIRHNESDPSLLWKHIQNMAVRRARGKN
What is the function of this protein?
Probable fucosyltransferase.
What are the official names of this protein?
Alpha-(1,3)-fucosyltransferase 11, Fucosyltransferase XI, Fuc-TXI, FucT-XI, Galactoside 3-L-fucosyltransferase 11, Fucosyltransferase 11.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 10 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: DDLB_PSEAE
Sequence: MNLCLDSLLNGTQDPKAFGRVAVLFGGKSAEREVSLKSGAMVLQSLLAAGVDAFGIDVGEDLLQRLVEEKIDRAFIILHGRGGEDGSMQGLLECAGIPYTGSGVLASALAMDKLRTKRVWLSLGLPTPDYAVLASEDDCREAAQRLGFPLIVKPAHEGSSIGMAKVGGLDELIAAWREAARYDSQVLVEQWISGPEFTVATLRGQVLPAIRLGTPHTFYDYDAKYLASDTRYQVPCGLDEAKERELKELTARACDALGIQGWGRADVMQDAEGRFWLLEVNTAPGMTDHSLVPMAARAAGLDFQQLVLAILADSREARG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase B, D-Ala-D-Ala ligase B, D-alanylalanine synthetase B.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y370_ANOFW
Sequence: MGVKYSSKINKIRTFALSLIFIGFFVMYGGIFFRTSPIVMTLFMILGLLFIIASTVVYFWIGMLSTKTVQVVCPSCNKVTKMLGRVDVCMYCNEPLTLDPTLEGKEFDEKYNRKTRDKKS
What are the official names of this protein?
UPF0295 protein Aflv_0370.
What is the protein family that this protein belongs to?
Belongs to the UPF0295 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y340_MYCPN
Sequence: MEHLNQEQKAAVTCDNGVNVVYSGAGTGKTTVIAERFAYLVNEKGVNPQSILAFTFTDKAASEMRQRIIKLIPQKSLQDLHIYTFHSFANRFLQKHGKSDFAILSDSNRFFSDYEMGDQLQTVVEIYKNKVVDLELDNLEYNSAFRDACTDTFNEDFSTISNGQFRKRAATALRAYQNYLITNNLFDFSDLIIETCHLLKGNSELLQAFTESVHYILVDEFQDTNLAQYELVKLLATTHPNLFLVGDSNQMIYGWRGAVVEIFELLKNDFQAVKEFYTTQNYRSIQAVLAVANDVLTAIARKERKALVLLHSSIDSKAVPVHYKANSLKNQDQWIIYQMKQLHLNNGVPYDQMAVLFRKNKHLDAFSQTVLEDGDLPLAKLNLLTIHAAKGLEFEAVFVYGLVERAFPSLHWDGSDKHKLLEEMKLFYVAITRAKQFLFLVSVSVESFNAYYEPSRFLKLIEKEHLQTQKAAYFKEQLKTQPKPVNLYTETENAENLQKATDSKKWIILGAILLIIVIITAVLKLFVEN
What are the official names of this protein?
Probable DNA helicase MPN_340, DNA 3'-5' helicase MPN_340.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
Protein: TAL_BRUA1
Sequence: MKFFVDTADVKEIRELNDLGLVDGVTTNPSLILKSGRDIIEVTKEICNIVKGPVSAEVAATEYEQMMKEAAVIARIADNICIKLPVTLDGLKACKALTSEGHKVNMTLCFSANQALLAAKAGATFISPFIGRLDDTGINGMELIAEIRTIYDNYDFRTEILAASVRTVNHVKEAALIGADVVTAPPATLKALVKHPLTDKGLETFLADWAKTGQKIA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INH5_TABYA
Sequence: MTSILVSRFLLAALVLQYATIDAVNYCNLPCRGDRFHVGCGESAFAQECGESPETRDLLKEHTDEILSKINDVRDHVAKGSWGLPMAARMKVVVWDEELARLATRHTKGCLAETHACRNTERFSFPGQLNFEYTDDKLPQTKELIDAAIKKGHLQKHNISREIIESYRDNGPDGNVEELALALSDRVTAVGCGLTTWQDGAKARALLTCNFSSQTLGVDLSTKSGIVLDEKCIERMNV
What is the function of this protein?
Inhibits platelet aggregation induced by all agonists tested (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and snake venom snaclecs (TMVA that activates platelet through GPIB, and stejnulxin that specifically acts through GPVI (GP6))) (PubMed:19531497).  May act by competing with fibrinogen for binding to glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:19531497).
What are the official names of this protein?
Tabinhibitin 5.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYLC_METBF
Sequence: MKTICLVGGKLQGFEAAYLSKKAGMKVVLVDKNPQALIRNYADEFYCFDVIKEPEKLLELSKRVDAVLPVNENLACIEFLNSIKEKFSCPVLFDFEAYRISRDKKKSKDYFKSIGVPTPQDRPSKPPYFVKPPCESSSVGARIIYDDKDLEGLEPDTLVEEYVEGEVVSLEVVGDGSHFAVVKETLVHIDETYDCHMVTPLPANPLFRQISHDLAANLPLKGIMDVEAIFGPKGLRVIEIDARFPSQTPTVVYYSSGINLIELLFRAFTDGVEEIRAIPENKYCIYEHLMFGENGVLIPVGEQVLSMGSDYGKFYEEPGIEIFLCKGEYPVFTMVFWGKDREETGAKRCKGLSVLKERFGAVL
What is the function of this protein?
Is required for the biosynthesis of pyrrolysine (By similarity).  Catalyzes the ATP-dependent ligation between (3R)-3-methyl-D-ornithine and L-lysine, leading to (3R)-3-methyl-D-ornithyl-N6-L-lysine (Probable).
What are the official names of this protein?
3-methyl-D-ornithine--L-lysine ligase, (3R)-3-methyl-D-ornithine:L-lysine ligase, Pyrrolysine biosynthesis protein PylC.
What is the protein family that this protein belongs to?
Belongs to the PylC family.
Protein: RNH2_RICCN
Sequence: MEVDLLHFEKKYHNCIVAGIDEAGRGPLAGPVVASAVIVDNANIITGIKDSKKLSKKKRELLYEQITSNYVWATAIISHTEIDDINILEATKKACSIAVANLSLEPEIVLVDGNMQFKDERFVSIINGDNLSLSIAAASIVAKVTRDRLMLDLSAEFPQYLWHKNSGYGTKEHIEAINIHGLSPYHRRSFRCC
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P7_TNVA
Sequence: MPKVESHHWRRRRILGNRLDGRGVVPPTTHHSGYQWYTTMAGSAKVLCTKNPWKRGGGG
What are the official names of this protein?
Uncharacterized protein p7.
Protein: SSU72_HUMAN
Sequence: MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY
What is the function of this protein?
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II.  Plays a role in RNA processing and termination.  Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.
What are the official names of this protein?
RNA polymerase II subunit A C-terminal domain phosphatase SSU72, CTD phosphatase SSU72.
What is the protein family that this protein belongs to?
Belongs to the SSU72 phosphatase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly in the cytosol.
Protein: PYRE_PICTO
Sequence: MLKEDLINSGAIKFGDFVLTSGKRSGYYIDIKSAYTDPKILDEIGLEISGMVKSGKIAGMELGSVPILVSVSIKTKRPFVIIRKDDLKHGTRKRYIGSINLNEEIDIIDDVATTGGSIMKAAEIIRNNGGIVKRAICVVDREEGAAEMLKENNIELYSIIKASELR
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: HLDE_PARL1
Sequence: MTVKSPDIQSLVEGLGHARVALAGDVMLDRFVYGHVERISPEAPIPVLRVDEERAMPGGAGNVARNLAALGAEVTFLSAVGDDEAGADLKAALEREGGIEAALTVVPGRTTTQKTRFVAMSQQILRADRETTQPLDAASAERLLAALTSALKDRQVLVLSDYGKGVLTPAFARGAIAAARAAGIPVIVDPKGRDYSLYAGASVVTPNRKELGEATGAAVDTDEEIVAAARALMKAHDIGAVVVTRAQAGMSVITADGAVTHLKAEAREVFDVSGAGDTVVSTLAAALGTGLTLAEAAGLANSAAGIVVGKVGTAVVHQDELLAKLRERELSMLEAKVAGLKSAEDIVAGWRARGLTVGFTNGCFDLLHPGHVTLLERSRALCDRLVVGLNSDASVSRLKGPERPVQPDIARATVLAALASVDLVVIFEEDTPEALIKALRPDILVKGGDYTIDKIVGADFVQAHGGRVEIVDIVPGFSTTGTLARLKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: PTH_SHIB3
Sequence: MTIKLIVGLANPGAEYAATRHNAGAWFVDLLAERLRAPLREEAKFFGYTSRVTLGGEDVRLLVPTTFMNLSGKAVAAMASFFRINPDEILVAHDELDLPPGVAKLKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTEMWFTDGLTKATNRLHAFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR5B_RAT
Sequence: MATEHLPAERAQSPLSAPQRVEEPQKPNYALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIFASFSVTGRKWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAALENDKTIKIWSSDY
What is the function of this protein?
May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.
What are the official names of this protein?
WD repeat-containing protein 5B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR5/wds family.
Protein: RS12_HELMI
Sequence: MPTISQLIRKGREVLTEKSTAPALKECPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGVEVTAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGALDTAGTQNRNQGRSKYGTKRPKKGAATAAKGPVKGKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: FPG_LACDA
Sequence: MPEMPEVETVRRTLRPLVVGKTIDHVDIWYDKVITGDPETFKRELKGKTFTAVDRYAKFLLFRLGDLTVVSHLRMEGKYHLTTWDAPVDKHEHLQFAFTDGSSLRYADVRKFGRLQLVETGTEFQVTGLKNLGVEANSPEFRLDYFEKGLKKRSMNIKSLLMSQTLVAGLGNIYVDEVLWQSRINPLTPANELTKDQVKQLHSAINETIEEATKYGGTTVHSFLNAEGGAGHYQEKLKVYGKEGQPCPRCGEDFVKIKISGRGTTYCLHCQKR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RL14_BACC4
Sequence: MIQQESRLKVADNSGARELLTIKVLGGSGRKYANIGDIIVATVKQATPGGVVKKGDVVKAVVVRTKSGARRPDGSYIKFDENAAVIIKDDKSPRGTRIFGPVARELRDSNFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MTP_DANRE
Sequence: MMPVAGLLLCVTAVLCTSALGAGPRLDNGKLYRYSYSTEVGLNRPTGSPGGNVGFRISSDVDINLAWRNPEIQDEQLLQVKISNIQVESAGKHSRKNNIFHGSSAESILGKVRLEALQRPFLVLWKMGKIRSLYAQKAEPATVKNLKRGVASMLMMQLKSGKMSEADASGKCLVEYKVNKHQVIRTKHLETCKSQETGFTTHSPVLGISGKCAAETVITLENGIIKSADAKETHVLSINARHKAATKVLSRQSLTLKAIEAGPAEVAGKDVAGVVKALDDKFLSVGVIVEKTKPKCKGCPNLMETWKAVRSQLEPNSLSKAEAPRSFLTLVHSLRKSSKSEILTVLQNCSKTALPQLVDAVTSAQTPSSLSAILEFLDFSKKDGLILQERFLYACGFASHPTESMLQSLLEVSQGKIGSTEIKESVVIIMGALLRKLCLKGACDLPAVLKVKELLLAGPDSTQEESEVQMYLLALKNALLPEGIPVLAKYAESEVGAYSTIAITALQRYDPALITAEVKKALNRIYHQNQRIYEKNVRAAAADVIMSSNPSYMEVKNLLLSIGHLPHEMNKYMLSKIQDVLRFQMPAYKLVRQVMKDMISHNYDRFSKTGSSSAYSGFMAETVDVTCTYNLDILYSGSGVLRRSNMNIYGQSNNALLHGLQVTIEAQGLESLIAATPDEGEEELESFAGMSALLFDVQLRPVTFFKGYSDLMSKMFSMSGDPINVVKGLILLTDHSQVIPLQSGLRASAEFQAGLSIDISGGMEFSLWYRESKTSVNNRGALVIIGNMTVDTDFVSAGVEVGFETEATLDFITTVQFSEYPFLVCMQMDKTTFPFRETVSKQEKLPTGQMFSRKRSRDQVVPGSEFPLHQENSNMCKKVFEPAW
What is the function of this protein?
Catalyzes the transport of triglyceride between phospholipid surfaces (PubMed:17924655).  Catalyzes the transport of cholesteryl ester, and phospholipid between phospholipid surfaces (By similarity).  Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:22581286, PubMed:17924655).  Required for yolk lipid utilization and absorption of dietary lipids in larvae (PubMed:17176039).
What are the official names of this protein?
Microsomal triglyceride transfer protein large subunit.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum.
Protein: CRCM1_MOUSE
Sequence: MHPEPAPPPSHSNPELPVSGGSSTSGSRRSRRRSGDGEPSGAPPLPPPPPAVSYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTDHDYPPGLLIVFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKRQAGQPSPTKPPAESVIVANHSDSSGITPGEAAAIASTAIMVPCGLVFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHSLTPGTHYA
What is the function of this protein?
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1.  CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (By similarity).  Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores.  May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion (PubMed:23840669) (By similarity).
What are the official names of this protein?
Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A.
What is the protein family that this protein belongs to?
Belongs to the Orai family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Colocalizes with STIM1 at the cell membrane.
Protein: TRPS1_XENLA
Sequence: MVRKKNPPLRNIASEGEAQITESAASKREDTISSKEISTDPMQENSEQSGLVEHNSDDHSFHDQEPSSSINKDSASLSLSERAVVNYSHLKGRNVYFSPMEVTDRNMLALVTTDTRSACDPLKSPIKSEADDTQELASSASVDSLEAKEENDMSPRATDFTVQCGKVDCQSSSPASVASDNLHVPSDGIAGLNKSQAVLLVNDNSDSAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDVELDTKILALHNMVQFSQSKDFQKMNRSVLSGVLQDFNSPRPVLLNGTYDVQVTFGETFIGIGRKTPDCQGNTKYFRCKFCNFTYLAKSATELEQHFLKTHPNKMKMSSDSGKPSEKSTNKSSPIPRSCEPGDLGKWQDKITVKAADDIPVGYSVPIKPVDSCRQNGTDDTNYYWCKFCSFSCESSSNSKLLEHHSKQHGGGKSESPNSDLNDEIFRGSVINQNEITKSSDEQLPTKIDKGLAKKKDVSSVPTEDIIVTNYNCQFCDFRYSKSHGPEVILVGPLLRHYQQHHNIHKCTIKHCPFCPRGLCTPEKHLGEITYPFACKKSNCSHCALLLLHLSSGGTESTRVKHQCDQCSFSSPDVDVLLLHYENAHEAQACEIKQELNHQHGADGQPSIKEIKEHSCTKCDFIVQVEEDLPRHYRRVHNCYKCRQCNFTAADTQSLLDHFNSAHCQEFEITTSNGGEHHGTSSIKEEPKTDLKVYNLVTPDSKMGEAIFDSTVKKEKLEDKETLREKAWSDGSVDDLRGVAWRAPDILRTSPSYSQMGLGLLTTVSVNQDQQKSSRDSPNVEAAHLARPVYGLSIEPKGFQGVTAGASGEKSGQHTPQYPTAGDSKSKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQPEQLTKHQRASSEEQANGSPLDIRSEDHSMEGHQRENQQLSMNKYGSQASLTKSHSAQQTMIVSQTMDIHKRMQPLHIQIKSPQESSGEPGNSSSVSDGKGSSERGSPIEKYMRPIKHPNYSPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCPNYVPYPTFNLPAQYSSVGSDNDIPLDLAMKHSRPGSGTNGDSKEKSKSPVSVKDDGPLNVTKIEKSDKSTQDELSTKCVHCGIVFLDEVMYALHMSCHGESGPFQCSICQHLCTDKYDFTTHIQRGLHRNIAQAEKNGKNKD
What is the function of this protein?
Transcriptional repressor.  Represses expression of GATA-regulated genes at selected sites and stages in vertebrate development.
What are the official names of this protein?
Zinc finger transcription factor Trps1.
What are the subcellular locations of this protein?
Nucleus.
Protein: ESS2_SCHPO
Sequence: MSLAKKIDDDEKQLVKPVNKEQTYKKPIPLEEDDYIEGLSYIIQQQYFPDLPKLKAEVVLESEEVGSFDAQNESRDEKLKYLIAKNSEDPLRKRLPSLAIHEITKAQLDGENKPISVASYQNKFTSEDNASFGELMEDESRLRAEQHKRRFGVHSQQPSNSIQTIGYSNSDAIKSIAWKEKDKSIKTWNYQPKNALMYTPETNHSSSLSQIKKQSTEIQADATGLSQSFLEAANQPSTDPIVPPSVNETDASVNGYPLVDVNFGQAVGSSSKSYFNIPERPRRERLHAMRVRDIRSHSTNTTITSVDSASTALNSYSTPNSVSRKLTNLTPAARRLVARSYLRSPLHGSSPSASRHTALRTSIPKFSWTPTPRVKSTAPTPKRV
What is the function of this protein?
Has a role in maintaining cell viability during stationary phase induced by stress response (PubMed:11751918).  May be involved in pre-mRNA splicing.
What are the official names of this protein?
Stress response protein bis1, Splicing factor ESS-2 homolog.
What is the protein family that this protein belongs to?
Belongs to the ESS2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During mitosis associates with the spindle microtubules.
Protein: PSB_METFA
Sequence: MDVMKGTTTVGLICDDAVILATDKRASMGNLVADKEAKKLYKIDDYIALTIAGSVGDAQAIVRLLTAEAKLYKMRTGKNISPLACATLLSNILHSNRYFPFLTQLIIGGYDLLEGAKLFSLDPLGGMNEEKTFTATGSGSPIAYGVLEAGYDRDMPVEEGIKLALKALKSAMERDTYSGNGISLAVITKEGVKIFEDEEIEKILNEITSKSKKKTTKRSRRKSK
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PsmB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEND_AERS4
Sequence: MFASQHATFNHVWSSLLLEELHRLGVRDIALASGSRSAPLTMAAAAHAGFRRHLHFDERGLGFMALGLAKGSGRPVAVIMTSGTAVANLWPAVAEAQLTGVPLIILSADRPPELIDNGANQAIDQQGIFGRYPVYQQNLPSPTPTIPAAFVLSSVDQVLAQQALTPGPVHFNCMYPEPLYPGDEYLDFSGYLAPLGDWLHSSEPWSPWQQNEQICPRQPDWAALQGKRGIIVAGRIQDPAQAQVVAELAERLGWPLLADLQSQIRFDARNLIHMDLALQNSCFVAELARAEVLLQFGARLISKRLGQFIKQHPWQDYWLVDPQPARLDPDYRLRRRLVCEPAAFAATHKVSTRHLPWHRLAERQQSATRQIRSACDRFSELGVCHRLGNLIQGQLFVGNSMPARLMDMLGEAGKGPSRVMTNRGASGIDGLIATAYGFAQSSEQPTTLLIGDLSALHDLNSLALLGKSSRPLVVILLNNDGGSIFRMLPVPTGDRLLETYYCLPHGLHFEHAAAMFGLHYRAPTTLAEFEQAYTAALKKPELEKKVTLIEIKVPSSEVAEDLKALGAAIRGL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: SRRMH_CAEEL
Sequence: MYNGIGLQTARGSGTNGYVQSNLSHLMQARRKIEYNGEDDLRKMEAELNRKPNEEIMDHNRKRQIEVKCTEFEMLLEDKGLDDEDIERKVGEYRKNLLKQLESGELNVDEELSTKESHARRRAAANNRDKMRNALGLGEDYVPGSSMAKMNKSDVVGAAMESELPQKDDKEKLLETLRLHRKSKKKQESSSSSSSSSSSSESSSEDEKHRKDRKKKEKKQKLKEMEKRREKLRQKERELLAVSDKVKKEEPAESSDEEDSRKDQRKPREDRRRSVERQDQREDRRDRRRSPEDPRERRRSPEDRTVRRRSPERRRQQRSPSVERRKSPQRRDERRRRHDSSENERRSTATASKKSRMDELEVKQEPPSDSEDYIAKTNLAPIRVEKSAEKVEKSRKSSSESSSGSSDSDSSSDSSSSSDSSSDSE
What is the function of this protein?
Plays a role in pre-mRNA splicing as component of the spliceosome (By similarity).  Involved in modulating global transcription, probably acting via interaction with RNA polymerase II (PubMed:23754964).  Influences the chromatin distribution and phosphorylation state of RNA polymerase II subunit ama-1 (PubMed:23754964).  Involved in regulating the germline sex determination pathway (PubMed:23754964).
What are the official names of this protein?
SRRM2 protein homolog rsr-2, SR protein-related rsr-2.
What is the protein family that this protein belongs to?
Belongs to the CWC21 family.
Protein: RPOY_LACAC
Sequence: MIYKVLYQKDKIVNPRRETTQTLYMEADNMVEARTMVEDNTPYNIELIQELTGNSLTYEKEHADFKLTKFDKK
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.