PharMolix/UniProtQA huggingface dataset:
Protein: TXLA1_CYRSC
Sequence: MKTSMFLTLTGLGLLFVVCYASESEEKEFPKELLSSIFAADSDFKVEERGCLGDKCDYNNGCCSGYVCSRTWKWCVLAGPWRR
What is the function of this protein?
Agglutinates human and mice erythrocytes.  This activity can be specifically inhibited by mannosamine.  This lectin shows very low toxicity in both mammals and insects.
What are the official names of this protein?
U5-theraphotoxin-Hs1a 1, U5-TRTX-Hs1a, Huwenlectin-1, Huwenlectin-I, SHLP-I, SHL-I.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8) subfamily. Hntx-8 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRB_BRASB
Sequence: MATSPKSTFVLGHRHLLGIEGLSAHDITGLLDLSEEYVELNRQVDKKRTVLRGRTQVNLFFEASTRTQSSFELAGKRLGADVMNMSVSSSSIKKGETLMDTAVTLNAMHPDILVVRHHASGAVELLARKVDGSVINAGDGAHEHPTQALLDALTIRRNKGRLEGLVIAICGDVLHSRVARSNILLLNTMGARVRVVAPSTLLPPGIERMGVEVARDMREGLNGADIVMMLRLQRERMNGSFVPSSSEYFQYFGLDQKKLAYAKPDALVMHPGPMNRGVEIDSIVADGAQSLIREQVEMGVAVRMAVLEALARNLPNA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: MANA_CANEN
Sequence: MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELXXKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFLQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKGEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFLDAALTQAKLTRTNHLMWTMGDDFQYQYAESWFKQMDKLLHHVNKDGRVNALYSTPSLYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRXXXXXXXXMLSGYYLATRHSGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLALGASKAEAVVSSSLACLTSKQSADQCSAPASAFSQCHLFNISYCPPTESSLPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKXXXXXXXXXXXXYWSLFKASVPPLGWSTYFISEATGKGTRNALTLSQKGETLNIGPGDLKMSFSSLTGQLKRMYNSKTGVDLPIQQNYLWYESSEGDFSDYQASGAYLFRPNGQPPPHTVSRSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGLYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTLRDDGRGVGEPLDEQVCMNKEYTCEGLTVRGNYYLSIHKPAGGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKAYAMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKLEELREVSLSANQEKSEMKKMKWSVEGDNEQEPQAVRGGPVSNADFVVELGPMEIRTFLLQF
What is the function of this protein?
Liberates mannose from p-nitrophenyl-alpha-D-mannoside (PubMed:12325362, PubMed:4973951, PubMed:1156387).  Liberates mannose from further alpha-D-mannosides including methyl-, benzyl-alpha-D-mannoside, 1-6-linked di-, tri- and tetrasaccharides of alpha-D-mannose and mannosyl-rhamnose (PubMed:12325362).  Liberates mannose from various glycoproteins like ovalbumin and ovomucoid (PubMed:12325362, PubMed:5145).  Does not hydrolyze beta-D-mannosides (PubMed:12325362).  Has glycosyltransferase activity, forming disaccharides from mannose and lyxose but not from glucose, galactose, ribose, xylose or arabinose (PubMed:12325362).
What are the official names of this protein?
Alpha-mannosidase, JBM, Jbalpha-man.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 38 family.
What are the subcellular locations of this protein?
Protein storage vacuole.
Protein: YL462_MIMIV
Sequence: MCKIYINMDNFDKQCEYYKNIENRRNNPIDLSKLDNPDNFVEIVANHVFSINENKLTDNLTQLLFDGETDIEGIFCVYLELILYGINILTNNTSSVFDLDNIENELIDKIQKYLGSCGIKMIVREELVDNIFMFRDKSSHYCEIVPKPPSFLCVNDWFVLNYRLITNVKNKVKSNFTDYWAFFVTNSGKTFSVRFDYKLS
What are the official names of this protein?
Uncharacterized protein L462.
Protein: BKN1_ARATH
Sequence: MGNCLKHFKQQLPSIAPKPLIIPPIFSARKRESESLQIRGLKKATKKFRQDRVVECEDYSVRKFYKGYIDETTFAPSRAGTGIAVSVMECDSSRSLQDWMAVVRSLGQLSHQNLVNFLGYCCEDNKPFFLVFEYSHKGSLDSHIFGKEEEALPWEIRVKIAIGTAQGLAFLHSIKNSPLNRELRMHNIMLDEQYNAKLFYLEPTKRSLVDEGLKRGRFTYLSPEWGSLGILDMTTDVYIFGMILLELLMGSKDRKKIKEEQGLVDYWTSSFLPDNYKIEEIIDPRLGSDYSANAATQMGTLINRCTAHNTKKRPLMQQVLDGLNHIAEIKD
What is the function of this protein?
Collaboratively with BKN2/SZE2, involved in compatible pollen-stigma interactions.
What are the official names of this protein?
Inactive serine/threonine-protein kinase BKN1, Pseudokinase BRASSIKIN 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: RF2_ACIF2
Sequence: MREVNEMRALHDDLQVRVAGLRGYLDLEEKRGRLEEVQRELEDPTIWNNAEKAQELGRERSALEAVITPMDKLTASLADGGEMLELALSEQDAELLAAVDADLDTALSLVEKLEFQRMFSGAQDAANCFVDIQAGAGGTEAQDWAEMILRMYLHWAESHGFAAELVEVSEGEVAGIKSASIHVRGDHAFGWLRTETGVHRLVRKSPFDSGNRRHTSFASVFVYPEIDDSFEVDINPADLKVDTYRASGAGGQHVNKTDSAIRITHVPSGIVVACQTDRSQHKNRAEAMRMLRSKLYEMEMQKRAVEKQALEDSKSDIGWGHQIRSYVLDQSRIKDLRTGVEVGDTQKVLDGALDMFIEAALKAGL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYV_ALIF1
Sequence: MEKTYNPQSIEQTLYQTWEEKGYFKPHGDTSKEAYSIMIPPPNVTGSLHMGHAFQDTIMDTLIRAERMKGKNTLWQVGTDHAGIATQMVVERKIAAEEGKTKHDYGRDAFIDKIWEWKNESGGTITKQLRRLGASVDWDRERFTMDDGLSAATQEVFVRLYEEDLIYRGKRLVNWDPKLHTAISDLEVENKDKKGFMWHFRYPLANGVKTADGKDYIVVATTRPETMLGDTGVAVNPEDPRYKDLIGKEILLPIVNRLIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRNQLPMINILTFNADIRESAEVFTTNGEVSDVYSTEIPAKYQGMERFEARKTIVAEFEELGLLEEIKDHDLTVPYGDRGGVVIEPMLTDQWYVRTAPLAEPAVKAVEDGQIQFVPKQYENMYFAWMRDVQDWCISRQLWWGHRIPAWYDNDGKVYVGRTEEEVREKNNLAPVVVLRQDDDVLDTWFSSALWTFGTQGWPENTDALKTFHPSEVLVSGFDIIFFWVARMIMMTMHFVKDEEGNAQVPFKTVYMTGLIRDENGDKMSKSKGNVLDPIDMIDGIDLESLVEKRCGNMMQPQLAKKIEKNTRKTFENGIEPYGTDALRFTLAAMASTGRDINWDMKRLEGYRNFCNKLWNASRYVLMNTEEHDCGMSLSAEERANMEFSLADKWIESQFELAAKEFNAHLDNYRLDMAANTLYEFIWNQFCDWYLELTKPVLWKGTEAQQQATRYMLITVLEKTLRLAHPVLPYITESIWQSVKPLVDGVEGDTIMTQALPQFNEENFNADVVADLEWVKAFITSIRNLRAEYDIAPSKGLEVMIKVADEKDAARIEANKVVLSSLAKLDEIKVLANGEETPACATSLVGKSELMIPMAGLIDKDAELARLAGEVKKTQGEIKRIEGKLGNEGFVAKAPEAVIAKEREKLEGYQETLVKLEAQQETIAAL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_ACICJ
Sequence: MAKTDYYELLGVSRGASADELKKAYRKLAMQYHPDRNPGDAAAEQKFKDINEAYDVLKDEQKRAAYDRFGHAAFENGGGPGAGGFGGGFGGFGGFEGGIGDIFEQMFGEAMGGRRGGRTERAGADLRAAVEIDLTQAFTGTKTEIRVPTRVSCDACSGTGSADKSAANDTCPTCGGAGRVRAQQGFFVVERTCPTCGGAGRTVRNPCRVCSGAGTVPRERTLSVTIPAGVEDGTRIRLSGEGEAGGRGASPGDLYVHVSIRPHPIFQRDGANVFCRVPLRMAQAALGGEIEVPAIDGTRARVKIPAGTQTGDQFRLRGKGFSVLRSTARGDMYIQVAVETPQNLTKRQRELLEEFEREAGNTASGSPEHEGFFAKVKEFFDGL
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRIL_HUMAN
Sequence: MEAARALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRGPGLQQPSPSVAAAAGPAPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAPSPAGDPWQRATKHRLGTEHQERAAQSDGGAGLPPLVSDPCDFNKFILCNLTVEAVGADSASVRWAVREHRSPRPLGGARFRLLFDRFGQQPKFHRFVYLPESSDSATLRELRGDTPYLVCVEGVLGGRVCPVAPRDHCAGLVTLPEAGSRGGVDYQLLTLALLTVNALLVLLALAAWASRWLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLIEFPCDRFMDSAGGGAGGSLRREDRLLQRFAD
What is the function of this protein?
Component of the TLR4 signaling complex.  Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.
What are the official names of this protein?
TLR4 interactor with leucine rich repeats, Leucine-rich repeat-containing protein KIAA0644.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: DSDX_ECO57
Sequence: MLPLYPDISPEIIAIAIGSGAIGCTIVTDSLFWLVKQYCGATLNETFKYYTTATFIASVVALAGTFLLSFII
What are the official names of this protein?
Putative D-serine transporter DsdX-like protein.
Protein: FLC1_YEAST
Sequence: MQVLVTLWCLICTCLVLPVAAKKRTLTASSLVTCMENSQLSANSFDVSFSPDDRSLHYDLDMTTQIDSYIYAYVDVYAYGFKIITENFDVCSMGWKQFCPVHPGNIQIDSIEYIAQKYVKMIPGIAYQVPDIDAYVRLNIYNNVSENLACIQVFFSNGKTVSQIGVKWVTAVIAGIGLLTSAVLSTFGNSTAASHISANTMSLFLYFQSVAVVAMQHVDSVPPIAAAWSENLAWSMGLIRITFMQKIFRWYVEATGGSASLYLTATTMSVLTQRGLDYLKNTSVYKRAENVLYGNSNTLIFRGIKRMGYRMKIENTAIVCTGFTFFVLCGYFLAGFIMACKYSIELCIRCGWMRSDRFYQFRKNWRSVLKGSLLRYIYIGFTQLTILSFWEFTERDSAGVIVIACLFIVLSCGLMAWAAYRTIFFASKSVEMYNNPAALLYGDEYVLNKYGFFYTMFNAKHYWWNALLTTYILVKALFVGFAQASGKTQALAIFIIDLAYFVAIIRYKPYLDRPTNIVNIFICTVTLVNSFLFMFFSNLFNQKYAVSAIMGWVFFIMNAAFSLLLLLMILAFTTIILFSKNPDSRFKPAKDDRASFQKHAIPHEGALNKSVANELMALGNVAKDHTENWEYELKSQEGKSEDNLFGVEYDDEKTGTNSENAESSSKETTRPTFSEKVLRSLSIKRNKSKLGSFKRSAPDKITQQEVSPDRASSSPNSKSYPGVSHTRQESEANNGLINAYEDEQFSLMEPSILEDAASSTQMHAMPARDLSLSSVANAQDVTKKANILDPDYL
What is the function of this protein?
May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.
What are the official names of this protein?
Flavin carrier protein 1, Bypass of PAM1 protein 1, FAD transporter 1, Heme utilization factor 1, TRP-like ion channel protein FLC1.
What is the protein family that this protein belongs to?
Belongs to the transient receptor potential (TRP) ion channel family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PGK_CHRVO
Sequence: MKFNKLSEQNLSGKRALIRVDMNVPLKNGVIGDDTRIRASLPTIEHCLKAGAAVLLMTHLGRPTEGEPKPEDSLAPVVARLSELLGKPVRLIADFHAGVELAPGEVAMLENVRLNKGEKKNNDELGRAYAALCDVFVHDAFGTAHRAEASTHAVAKFAPVACAGLLLSAELDALGKALQAPARPLVAIVAGSKVSTKLTILEALADKVDQLIVGGGIANTFLLAEGKAIGKSLAEADLVEDARRVIAKIRARGGDVPLPADVVCAKEFAETAAAATKNVAEVVADDMILDIGPDAAKQLAAIIAQAGTVVWNGPVGVFEFDQFGNGTKTLAQAIAQSKAFSIAGGGDTLAAIAKYGITDDISYISTGGGAFLEFLEGKELPAVAILAERAQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POL1_TBRVM
Sequence: MSVTLSPPGDCFTFNHVKYNNSLNKYLFYNNNLDIVLDDFDFYFNFYAKKYNVLSSFFSDRVLSALYTPMSVSEAASLALEDFCELALDKLKINPFHQLWEETLANWPVYPGTSLLDFFRTQYEIRREVAEASAEALRLKKATRADAFADEVKFLIKNGVLPHLAGDFARKIWSTGKDQKKTRTAFLVKIKKANQLKQQWNSARSLAAARAEVLREFEPSPQQIQKAIEAQLFAEKLGRKYATLTARVRAKRAAARELREKQLYQETVDLLNASLLPPMEKVEIERKYRKVRPTGANVVHQVVANPLGSLCPYMGLGAKTADVRCQATLMAGKIHAQYPRLATAIYAWVIGPAAHFECITPVRNFVKGLTFMVDFFPEEALIHELNEITTEAVCIGASMVLDEERAKLEAHAQSANCRANVFMKAMAGVKNMAKCAYTGFKTGCEEAGRSLAEGICSVMMRSFRECIAQIKTELGCAIEMVEVMIKKVKDWFYSMLEKLQCGLETLGSYAMYALAILLGCGLTSLLERCIGGQGILTKLFITGVLAAIGLQAAGGFDNLQREMVQLCTALAAGIFDIQHAGNGKYKPSWDITAEHAREDARDSNVRSIPIISGVIEALAQFGTGLCSMQSATLIEIGKIGAACHSMRMGKEALKEFCATLMYYLGRIADKVTGRETIFFDELSTLVHVDVRGWIKRAQSCMRESFHTEIGNQFFRDMVAQLVDEGQKLQIGVNGIPRKISADYSQLIGQIMKDLVELHKRTIRAGISEGRRCEPVWIYLFGQRHCGKSNFMSTLDNALAKHFNLPNTTAYRNCKDAFYSGYSGQTFFHMDDLSSVKLEPPLEAELINLVSCQEVPLNMADLADKPIYFRSPFIISSSNFEDVPAGCGVRDIEAYRARKACLVEMRRKPGVIYDPENPLLASQARFKDPMYQTLINGQTEETSWMEMDDVVTEIINISARHRSAQEKLQARYMREKALLDPLALASESFLVKEAQKVFLDFDGVELEKAGVPRPEGGHGLYVDGVLYLVNASFEFDEIPIKDGGYQRLWDSRMRKKFLPAIQRDEHLNTKSMVVTGFLRSLVNGECAVLSKDTLTASATTAQLSIFKALRLEERVYLRTLQHQLDLYSQDIPENPYCNSAWVKVLGAIGAGRDYLVQNGCGILMIAAALILILVSGWGFWKLFVGLFSGTMSLGAAITGMSAVDIKAQQSSASQEKGYRARNIPIHHRYAYARSQAGDGLLPAARLCVAIYQPGGGFVSAMQYKNKSVRMTRHQALRFKEGEQLTVIFASTGESQLIRWHKYHMREEHGSEIVTWLAPSLPALSPDLKDLFLEDKEVDLPNHFKTIGYVLRVDSTAFHYDTLDTYGAVDKTPLPLKGVVGNELYLHEIPEKIVFHYESRNDDCGMIMLCQIRGKMRVVGMLVAGKDKTSWADIMPPNSLAELKSQIDYIPEFGEACDGYFKAGYVHKSEAPTLPKKTNMVPVPESLRVPCDVPVKEPAVLTKDDPRCPIGVDPPRAALKKKFTQPMMELEQEILDEVATDILETWYDCEDHVLSDISLSVAINGIPADSEEAELENFVMKTSPGYPYFKNNRAEKLKGKHAYFEEAEDGSLQLKKGGMAAELHENLVEFTKNEVPELVVIECTKDELLPERKIKVGACRLFEIMPLHYNLFLRQKTCAFTQFLQHNRHRLPCQVGTNPYSREWGHMLNRLMRPKTNEAINCDYSGFDGLLNPQLIECIARMINRLYALSGESDVQQAQRYNMLMALVGRYAFVGQQVYKVNCGLPSGFALTVVVNSVFNEILIRYAYKKLAPAPERNRFGSTVCLLVYGDDNLISVSPSIASWFTGEAIRITLAEKKVKITDGSDKDAPTIEAKSFWELDFLKRKFLKLDNGIVQAPLDRSAIFSSLYWLTPDKSKFHESQKPSDFQGEVDVIEELLLNVNVALMELYLHNDVAEFQRVRGFYAQRLPLMVSQLRTWAFCEAFHSAQQTGMQKYDPAVVLDHMSGVDFKRFMHMSEQGNKAHFYTEMLGVSGPHYKPQEGDFIVSNQPLKPGVQGEYVPIVFGEGIGGLPTKKWVGDFGKPSQLKNSKGYLITGLLREQIEAGKRLIFMGPAPYVANNAALISFGSAHKMLIQKDALAHYRNVIPESTSGLEQYFDAPIPQASVGTFYFGDGETYTALCEYKDGKVLQYEGLPTAILNQAAKDRKVPCMVARQWKSKFTVRMACDSNMCPHHSATCANFELAFKQCWLSKCKCAGNNVSKWYGTKFS
What is the function of this protein?
Picornain 3C-like protease is a thiol protease that cleaves the P1 and P2 polyproteins.
What are the official names of this protein?
RNA1 polyprotein, P1.
What is the protein family that this protein belongs to?
Belongs to the nepoviruses RNA1 polyprotein family.
What are the subcellular locations of this protein?
[Viral genome-linked protein]: Host endoplasmic reticulum lumen. SUBCELLULAR LOCATION: [Putative ATP-dependent helicase]: Host endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: ACT3_LYTPI
Sequence: AEREIVRNIKEKLCYVALDFEQEMQTAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETCYNSIMKCDVDIRKFLYANTVLSGGSTMFPGIADRMQKEITAFAPPTMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, cytoskeletal 3, LPC3.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton.
Protein: TRMB_STAAN
Sequence: MRVRYKPWAEDYLKDHPELVDMEGQHAGEMTEWFDKTQPIHIEIGSGMGQFITTLAAQNPHINYISMEREKSIVYKVLDKVKEMGLTNLKIICNDAIELNEYFKDGEVSRIYLNFSDPWPKNRHAKRRLTYHTFLALYQQILNDEGDLHFKTDNRGLFAYSLESMSQFGMYFTKINLNLHQEDDGSNILTEYEKKFSDKGSRIYRMEAKFHSQK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: TLR4_PONPY
Sequence: MMSASRLAGTLIPAMAFLSCVRPESWEPCVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQNLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCKDLQVLHQMPLLNLSLDLSLNAMNFIQPGAFKEIRLHKLTLRNSFDSLNVMKTCIQGLAGLEVHHLVLGEFRNEKNLEKFDTSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLANVSSFSLVSVTIKSVKDFSYNFGWQHLELVNCKFGQFPTLELKSLKRLTFTANKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNDVITMGSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLKVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLNITCQMNKTVIGVSVFSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENTYDAFVIYSSQDEDWVRNELVKNLEEGVPTFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTG
What is the function of this protein?
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS).  Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate.  In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42.  In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36.  This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.  Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).  Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (By similarity).
What are the official names of this protein?
Toll-like receptor 4.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Early endosome. Cell projection, ruffle. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation.
Protein: UBIA_PASMU
Sequence: MPISKQKWIAYAQLMRFDKPIGTLLLLWPTLWALFLSVKGMPDLSILSIFVLGVIFMRAAGCVINDYADRHIDGAVKRTSKRPLATGAATPEEAKWLFVLLVFCSFILVLFLNTYAIVLSFIAVFLAFIYPFMKRYTHLPQLFLGMAFGWSIPMAYGASIEALPLECWLLFFANLAWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIISLLQIVTLFFLGLIGYLSQLHTSYFVVLFLATLLFVYQCKLIKDRERESCFKAFLNNNYFGAMVFVAFLFGIFFDKL
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: C71AJ_PASSA
Sequence: YFFPLFLVTIFLYKWLVKKTPSKNLPPSPPRLPIIGNLHQIGPDPQISLRDLAREYGPVMHLKFGSVPVLVVSSADGAREIFKTHDLVFADRPYSSVANRIFYNGRDMVFARYTEYWRQVKSTCVTQLLSVKRVQSFHNVREEEVALLLDNIENSKSKVINLSEMLIELTGNVVCRAALGSGYNVDSYKSLLLQIMDMLGYSRSIEDFFPSLGWVDWITGLKGKVEKAANGVDAFLEGVLKNHTNPSTSSANKDFVSILLEIQEADAGSSMDKECIKSLIWDMLGAGTETIATALEWTIGALIKSPDAMSKLQKEVREIGKGKSRIEEGDLVKMDYLKAVMKESMRLYFTAPLLVPREARQDVKFMGYDIKSGTQVLINAWAIARDPSSWDNPEEFRPERFLNSPIDYKGFNYEYIPFGAGRRGCPGIQFAISVNELVVANVVNKFNFELPDGKRLEEMDMTASTGITFHKKS
What is the function of this protein?
Involved in the biosynthesis of coumarins and furanocoumarins (FCs), natural products required for defense responses against attacks by predators with potential medical and agroindustrial usages such as anticoagulant, rodenticide and artificial vanilla substitutes (PubMed:29971079).  Involved in linear furanocumarin (psoralen) biosynthesis (PubMed:19098286).  Converts marmesin to psoralen and, with much lower affinity, 5-hydroxymarmesin to bergaptol (PubMed:19098286).
What are the official names of this protein?
Psoralen synthase, Cytochrome P450 CYP71AJ3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein.
Protein: RS20_ORYSJ
Sequence: MAAADVAYAPPMKSGKIGFESSQEVQHRIRITLSSKSVKNLEKVCGDLVKGAKDKSLKVKGPVRMPTKVLHITTRKSPCGEGTNTWDRFEMRVHKRVIDLVSSADVVKQITSITIEPGVEVEVTISDQ
What are the official names of this protein?
40S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: METK_SHEB5
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILAQDPKARVACETYVKTGMVLVGGEVTTSAWVDIEEITRKTVREIGYTHSDMGFDADSCAVLNAIGKQSPDINQGVDRADPAEQGAGDQGLMFGYANNETDVLMPAPITYAHALVKRQSEVRKNGTLPWLRPDAKSQVTFAYDDGKIVGIDAVVLSTQHRDDVSQADLIEGVMETIIKPVLPAQWLNKDTKFFINPTGRFVIGGPVGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSISIETFGTGKVSEDLLIKLVRQHFELRPYGLTAMLDLARPIYQATAAYGHFGRNEFPWEATDKAEILRADAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRPF3_BOVIN
Sequence: MALSKRELDELKPWIEKTVERVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRDLKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQASIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD
What is the function of this protein?
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
What are the official names of this protein?
U4/U6 small nuclear ribonucleoprotein Prp3, Pre-mRNA-splicing factor 3.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: Y3606_ALIF1
Sequence: MNNVFEIINQARRKNKLKRELQDNQKKIRDNQKRVTLLENMLDYIHPTMTTAEVIAVVENMKADYEDRVDDHIIKSAEISKSRRDISRKIRELTEADKKANK
What are the official names of this protein?
UPF0265 protein VF_A0606.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: RS19_CUTAK
Sequence: MPRSLKKGPFVDEHLAKKVTAQNEAGTHNVIKTWSRRSMVTPDMIGHTIGVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHVKDDKKARRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.