PharMolix/UniProtQA huggingface dataset:
Protein: PURA_HAEI8
Sequence: MGKSVVILGAQWGDEGKGKIVDLLTDRVKYVVRYQGGHNAGHTLIINGEKTVLRLIPSGMLHPNVTCLIGNGVVVSPEALMKEMGELESRGIKVRERLLISEACPLILPYHVAMDHAREAALGKKAIGTTGRGIGPAYEDKVARRGLRVGDLFNKEAFAEKLKNILEYYNFQLVNYYKVEPVDYQKTLDDVMAIADVITGMVADITTILDTARKNGEHILFEGAQGTMLDIDHGTYPYVTSSNTTAGGVATGSGFGPRNLDYVLGIIKAYCTRVGGGPFTTELFDDVGAEIARKGNEFGAVTGRPRRCGWFDAVAIRRAIQLNSISGFCMTKLDVLDGFDEVKICVAYKMPNGEIVEYAPLAAKDWEGVEPIYETLPGWKENTFRITDVNKLPQNCINYIKRIEEVTGVPIDILSTGPDRVETMILRDPFAA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUCO2_RAT
Sequence: MRLGLLMFLPLLLLATRYRAVTALSYDPTWESLDRRPLPAWFDQAKFGIFIHWGVFSVPSFGSEWFWWYWQKERRPKFVDFMDNNYPPGFKYEDFGVLFTAKYFNANQWADLLQASGAKYVVLTSKHHEGFTLWGSAHSWNWNAVDEGPKRDIVKELEVAVRNRTDLHFGLYYSLFEWFHPLFLEDQSSAFQKQRFPVAKTLPELYELVTKYQPEVLWSDGDGGAPDHYWNSTDFLAWLYNESPVRDTVVTNDRWGAGSICKHGGYYTCSDRYNPGHLLPHKWENCMTIDKFSWGYRREAEIGDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGIIPVIFEERLRQMGTWLKVNGEAIYETHTWRSQNDTVTPDVWYTSKPEKKLVYAIFLKWPISGKLFLGQPIGSLGETEVELLGHGRPLTWTSSKPSGIVVELPRLSVHQMPCKWGWTLALTNVT
What is the function of this protein?
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
What are the official names of this protein?
Plasma alpha-L-fucosidase, Alpha-L-fucoside fucohydrolase 2, Alpha-L-fucosidase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 29 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECA_CAMLR
Sequence: MDDNKRKSLDAALKSLDKTFGKGTILRLGDKEVEKIDSIPTGSVGLDLALGIGGVPKGRIIEIYGPESSGKTTLTLHIIAECQKKGGVCAFIDAEHALDVKYAKNLGVDTENLYISQPDFGEQALEIVETIARSGAIDLIVVDSVAALTPKAEIEGDMGDQHVGLQARLMSQALRKLTGIVHKMNTTVIFINQIRMKIGMMGYGTPETTTGGNALKFYSSVRLDVRKTATLKQNDEPIGNRVKVKVAKNKVAPPFKQAEFDVMFGEGVSREGELIDYGVKLDIIDKSGAWFSYKASKLGQGRENAKAFLKENPAIADEITQAIQNSIGIDSMILGAKEDDEGEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_STRP1
Sequence: MINGIINLKKEAGMTSHDAVFKLRKLLQEKKIGHGGTLDPDVVGVLPIAVGKATRVIEYMTEAGKVYEGQVTLGYSTTTEDASGEVVARSSLPAVLTEELVDQTMTTFLGKITQTPPMYSAVKVNGRKLYEYARAGESVERPRREVTISLFERTSPLNFTEDGLCRFSFKVACSKGTYVRTLAVDLGRALGVESHMSFLQRSASAGLTLETAYTLGEIADMVSKQEMSFLLPIEYGVADLPKMVIDDTELTEISFGRRLSLPSQEPLLAAFHGEKVIAILEKRDQEYKPKKVLI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: MNMA_XANOP
Sequence: MSTPHIVVGVSGGVDSSVAAWKLAQQGEPIAGLFMQNWADDGSGDCRAEDDRRDAVAVCGVLGMPFHFRDFSGEYWSGVFEHFLAEYAAGRTPNPDVLCNREVKFKHFLDAAQALGAERIATGHYAQVAHRGGRWRLLRGADRDKDQSYFLHQLGQSQLAATLFPIGDLEKSTLRRIARDAGLPTHAKKDSTGICFIGERDFREFLGRYLPARTGEIRDPQGQRIAEHPGVFYFTLGQREGLNIGGVRGRAAAPWYVVGKDVASNVLYVDQDRDSPLLQSRWLQSEQAHWVTGAPPARRFSCTAQTRYRQPDEPCTVDVQDDGSVQVHFERPQRAVTPGQSLVLYDGKECLGGAVIAATDAPLERQLAGSSFSSEVVA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELS_HUMAN
Sequence: MERQEESLSARPALETEGLRFLHTTVGSLLATYGWYIVFSCILLYVVFQKLSARLRALRQRQLDRAAAAVEPDVVVKRQEALAAARLKMQEELNAQVEKHKEKLKQLEEEKRRQKIEMWDSMQEGKSYKGNAKKPQEEDSPGPSTSSVLKRKSDRKPLRGGGYNPLSGEGGGACSWRPGRRGPSSGGUG
What is the function of this protein?
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins.  Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner.  Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
What are the official names of this protein?
Selenoprotein S, SelS, VCP-interacting membrane protein.
What is the protein family that this protein belongs to?
Belongs to the selenoprotein S family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm.
Protein: GP1_BPPZA
Sequence: MIKSSVGGNEGKSKFFDQEKRLERTWNNSNWGKQGIISPVDGDMKIIDIELEKKMTKLEHENKLMKNALYELSRMENNDYAAWVIKVLFGEVAHGAK
What is the function of this protein?
Protein that assembles into highly ordered structures and provides a specific site for viral DNA replication.  Probably anchors the viral DNA replisome to the host membrane.
What are the official names of this protein?
DNA replication protein 1, Gene product 1C, gp1C.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus DNA replication protein 1 family.
What are the subcellular locations of this protein?
Host membrane; Peripheral membrane protein.
Protein: ISPH_SYMTH
Sequence: MEVIKITPRGYCHGVVGAIQLVRRVARDPNVPRPIYVLGQIVHNRHVVEEMEALGVITLDGEDRLSLLEKIDAGTVIFTAHGVSPAVKIRAREKGLYVVDATCPDVTRTHELIAELVSRGYEVIYIGKKGHPEPEGAVGVAPGHVHLVERAEDLEALSFAPGQKLAVTNQTTLSQWDTQALMEQVKARWPQTEIYNEICLATQQRQEAVARMAPEADLVIVVGDRRSNNSNRLVQVAQELAAREAHLVDSVEEIDPAWLKGKRKVAVTSGASTPTHITRAVIEFLEKYNVEVEER
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: LPXK_PSEE4
Sequence: MAFADRLLAAWYAGHPALALLRPLEALYRRVVTRKRARFLSGESASYRAPVPVIVVGNITVGGTGKTPMILWLIEHCRRQGLKVGVVSRGYGAKPPQHPWHVQADQPAEQAGDEPLLIVQRTGVPLVIDPDRSRAVQALLASDAPDLILCDDGMQHYRLARDLELVLIDAVRGLGNRRCLPAGPLREPAERLGEADAVLFNGAEADRDDGFSFRLQPSALINLRSGERRALDLFPAGQALHAVAGIGNPQRFFNTLLGLNWQPVPHPFADHAPYSREVLSFSPPLPLVMTEKDAVKCRPFAADDWWYLAVDAVPSAAFSAWFDGQLDRLLPGRPRP
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: YIDD_CLOPS
Sequence: MKKLFIVMIKFYRKYISPLKRPCCRFYPTCSQYALEAIQKYGAFKGGFMSIGRILRCNPFCKGGYDPVK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SIR5_HUMAN
Sequence: MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
What is the function of this protein?
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469).  Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693).  Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062).  Activates SHMT2 by mediating its desuccinylation (PubMed:29180469).  Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity).  Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.  Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
What are the official names of this protein?
NAD-dependent protein deacylase sirtuin-5, mitochondrial, Regulatory protein SIR2 homolog 5, SIR2-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Mitochondrion. SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion.
Protein: PHS_SHEAM
Sequence: MSELASMKCEACQADAPKVTDAELAELIRMIPDWSVQVRDGIMQLERVYKFKNFKLAMAFSNKLAELAEEEFHHPGIFTEWGKVTVTWWSHSIKGLHRNDFIMAAKTDQLLD
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: SEPF_BACAC
Sequence: MSWSKVKYFFFDTPEEKEAAQYSYEKEQTDMKKQQDPPEQQDVTFPKAQPKQNVVSIETAKQSSKVVLLEPRTYSEAQGIADHLKGRRAVVINLQRMSTDQAVRIVDFLSGTVYAIGGDIQKIGPKTFMCTPENVDIVGAISELFGEEDDTNIKRW
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: UAP1L_XENTR
Sequence: MDRSESAESAESRRRRAEESGQGQLFRFWDELSPAEKEALLEQLEMLEPRELREHCQRAREAYVRESSAPQRLDDRMQPVPPEFLGSVRHSGTGELERWEREGFHQIAQNKVAVLLLAGGQGTRLGVTYPKGMYSVGLPSAKTLYQIQAERIRRLQQLASERHGETCTVPWYIMTSEFTLGPTRKFFEDHAYFGLERSDVVMFEQRMLPAVGFDGAAILEDKAKLAMAPDGNGGLYRALSDNRILEDMEGRGIQYVHVYCVDNILVKMADPVFIGFCVSKGADCGAKVVEKGYPAEPVGVVCRVDGVYQVVEYSEISPETAEKRNPNGALTFTAGNICNHFFTVPFLRAVIGSLEPRLNYHVAIKKVPYVDNEGNLVKPTSPNGIKMEKFVFDVFQFAKNFVAFEVLREEEFSPLKNADTADKDTPTTARRALLWQHYRWARRAGTHFLDETGSPIRDSHSISGEGDPPAVCEISPLVSYFGEGLESYMKDKDVSSFPFVLESSDAGPVPV
What are the official names of this protein?
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 1 family.
Protein: RNFE_ERWT9
Sequence: MSEAKTLLVGGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTCTNSAISLSRRWVPAEIRIPIYVMIIAAVVSCVQMLINAYAYGLYQSLGIFIPLIVTNCIVVGRAEAVASKSSVPLSALDGMAIGLGATSVMVVLGSIREIIGNGTIFNGADQLLGPWAKAMHIQVVHFDSPMLLAMLPPGAFIGLGMLLAAKYLIDNKMKQRATLKAESQAQGLPEGKTGAL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUOB_PSEA7
Sequence: MQYKLTRIDPDAANDQYPIGERETVADPLVEGQVHKNIFMGKLEDVLNSTVNWGRKNSLWPYNFGLSCCYVEMTTAFTAPHDIARFGAEVIRASPRQADFMVIAGTCFIKMAPVIQRLYEQMLEPKWVISMGSCANSGGMYDIYSVVQGVDKFLPVDVYIPGCPPRPEAFLQGLMLLQESIGQERRPLSWVVGDQGVYRADMPAQKDLKREQRIQVTNLRSPDEV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CCME_RHILE
Sequence: MTRNRKRLAVIAGGMGFILTAVLLVMFAFSQSVAYFYMPADLAKTPVAPETRIRLGGLVGEGSVVRGTGSTVEFAVTDGSTNPVKVKYTGILPDLFRGGQGVVTEDMFAAGTNVFVADTVLAKHDETYMPKDVADRLKSQGLWKEGQGQEAQGKQAQGQEVKATP
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: NUOB_NITSB
Sequence: MAQHQVNYASNAGLPVALTTVDKLVNWGRTNSLWVLTYGLACCAIEMMASGASRYDFDRFGVIFRASPRQSDVMIVAGTLTKKHAEFIRRLYDQMAEPKWVISMGSCANTGGMFNTYATVQGVDRVIPVDIYLPGCAPRPETLQYAVMLLQKKLRKRSIFQKQKPKRLV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ZN576_HUMAN
Sequence: MEDPNPEENMKQQDSPKERSPQSPGGNICHLGAPKCTRCLITFADSKFQERHMKREHPADFVAQKLQGVLFICFTCARSFPSSKALITHQRSHGPAAKPTLPVATTTAQPTFPCPDCGKTFGQAVSLRRHRQMHEVRAPPGTFACTECGQDFAQEAGLHQHYIRHARGEL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 576.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLPK1_PSEAE
Sequence: MSHYLLAIDQGTTSSRAIVFSAQGLPVASCQQEFKQYFPKDGWVEHDGEEIWLTTLQVCRDALARKGLRAADIAAIGITNQRETTLVWDAASGDLIHPAIVWQDRRTADYCAELKAAGHEANVSARTGLLIDPYFSATKLRWILDNVPGARQRAERGELRFGTVDCFLLWRLTGGRSHRTDATNASRTLLFNIHSQDWDEELLALFEIPRSLLPEVLDCAAEFGVSEPSLLGAAIPVLGMAGDQQAALIGQACFQPGMVKSTYGTGCFMIQNTGEQPVTSKNRLLTTVGYRLDGKVSYAVEGSIFVAGAAVQWLRDGIKLIDHAHESEALAIQAGDSNGVYLVPAFTGLGAPYWDPKARGAIFGLTRDTGIKEIVTAGLQSVCYQTRDLLEAMRQDGTPPSALRVDGGMVVNNWMMQFLTDILGVTVERPEVTETTALGVAYMAGLKAGFYRDLDDIASHWHLQRRFAAHMAEERRGELYAGWQNAVRRVRSEA
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase 1, ATP:glycerol 3-phosphotransferase 1, Glycerokinase 1, GK 1.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: CCA_STRMU
Sequence: MRLKHLPSEFQEALPVLEKIKAAGFEAYFVGGSVRDVLLGHPIHDVDIASSSYPEETKKIFPRTVDIGIEHGTVLVLENGHDYEVTTFRTEDLYVDYRRPSQVSFVRSLEEDLKRRDFTINAFALDEKANIIDKFNGLVDLEQKILRAVGNAAERFNEDALRIMRGLRFAAQLNFDIEKKTFIAMREHAPLLEKISVERSFIEFDKLLRAPYWRKGINCLIASQAYDYLPLLQSTADKWQQLLTDLPEDFTFSTSEQAWAAVLLYLNVENPRSFLKSWKTSNDFQKTVEKLLAIYRLREDRQIKKTDVYQYSATLLTLVEELRQAQGLAVDFEHIKELDEALTIHDKHEIVVKGGDLMAAFDLKPGPDLGKILNQIESFIVAGNLANERQAILDFVRKEID
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: TGT_FRAP2
Sequence: MTVMKFDLIKKEGKARRGKISFPRGDIQTPAFMPVGTYGAVKSLSPVELKEMGADIILGNTFHLWLRPGTEIIKKHGTLHDFNGWDKPILTDSGGFQVFSLGKMRKLTEEGVTFKSPINGSKVFLSPEISMQVQRDLGSDIVMCFDECTPYPATEKEAKDSMELSMRWAKRSKDAHGDNPSALFGIIQGGMYEHLRDESLKALKEIDFDGFAIGGLSVGEPKEDMIRILDHTAHQMPEDKPRYLMGVGTPKDLVEAVYRGVDMFDCVMPSRNARNGHMFTSEGVVRIRNAKHKDDVSLLDPNCDCYTCQNFSRSYLHHLDKTQEILGSRLNTIHNLTYYQNLMKNIRQALEEGRFEEFRKEFLENYKG
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RL24_XANC8
Sequence: MANRIKKGDQVVINTGKDKGKQGEVVRVEGDRVIVSNANVIKRHTKPNPQAGVAGGVVEREASIHISNVNIVNPATGKGERVGFKVLEDGRKLRVFRSSGEALDA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MATK_PINPI
Sequence: MDEFHRCGKEDSFWQQCFLYPLFFQEDLYAISHDHYLDVSSSSRPMEHLSSNDQLSFLTVKRLIGQIRQQNHSIVLFVNCDPNPLADRKKSFYSESVLEALTLVLEVPFSIWSKSSVEGMNECKSFRSIHSIFPFLEDKFPHSNSILDARIPYSIHPEILVRTFRRWIRDAPSLHPLRSVLYDYRNSPENLQRSIIVVPRVNTRFFLFLLNYYVCECESILFSRLKRSSHSRSLTHGSFPQRTHFHRKIKHIIIFSRRNSLKTIWSLKDPKIHYVRYGERPIIAIKGAHLLVKKCRYYLLIFRQFYFHLWSEPYRVCSHQLSKNCSSSPGYFLRVRMNPIFVRTKMLDELFIADLITNEMDPIVPIVPIIGLLATEKFCDISGRPISKLSWTSLTDDDILDRFDQIWRNLFHYYSGSFDRDGLYRIKYILSLSCAKTLACKHKSTIRVVRKELGPELFKKSFSKEREFDSLPFSSKAAARSQRERIWHSDIPQINPLANSWQKIQDLKIENLFDQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y575_WOLSU
Sequence: MRHLRKISDYAIIGSLGALIAVGLQGCDNNSSSKSEPLSQIKEKQGALVIIEEQPQGGYKILEEYPSETTRIVLKDPSGKERMLTQEEVDKLLKEEAAKIEQGTSQLTNPGGMGLSLGETILASMAGAMLGSWIGSKLFNNPNYQAQQRATYKSPQAYERSQNSFKSSSSATAPRGTSTGASSTPSSAKGGYFGSSSSPSSAPSSSSSSSSSPSYGG
What are the official names of this protein?
UPF0323 lipoprotein WS0575.
What is the protein family that this protein belongs to?
Belongs to the UPF0323 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: Y868_THEGJ
Sequence: MIVIVTGMPGSGKSRIVEEFEKRGFPSVSLGDIVREETVKRGLELTKENVAKVSIRLRQELGQNAVAKLAVGKVRVLLEKSPLVVIDGVRSLDEVGTFRGAFPEEKIIIVAVHTPPRLRFERLKARGRHDDPQTWEDFEERDWKELRFGIGGVIAMADHMLINDGSKEEYEKKVKTLVEKIIRGLNRGGA
What are the official names of this protein?
UPF0200 protein TGAM_0868.
What is the protein family that this protein belongs to?
Belongs to the UPF0200 family.
Protein: PIMT_BORBR
Sequence: MRKRVDPPAGGRLAPGITPANSNTRISAGALPRAPAQPAPLASGNLGLNSDRLRQAMVQRLRTQGIVDERVLNAMAAVPRHLFVDEALASRAYEDAALPIGHSQTISQPWVVARMIAAVCEDRAPARVLEVGAGCGYQAAVLAQIVREVHAIERIRGLYELARGHLRALRLATRVRLIHGDGMLGVPGVAPFDAIVVAAAGLAIPQALLDQLAPGGRLIAPEGSTHQRLVLIERTGATAWSRKELEAVRFVPLRAGIQS
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.