PharMolix/UniProtQA huggingface dataset:
Protein: TRPA_STAES
Sequence: MSKLFIPYIMGDLNFIHHLKTLTENGADIVEIGVPFSDPVADGPIIMKAGRNAIDEGSNIKFIFDELIKNKNTISSKYVLMTYYNILSAYGEELFLDKCDEAGVYGLIIPDLPYELTKKFKKDFYHHSVKIISLIAMTASDARIMQIAKNSEGFIYTVTMNATTGNSGEFHPDLKRKIEYIKKVSKIPVVAGFGIKNPEHVKDIASVADGIVIGSEIVKRIEIDSRKEFITYIKSIRTTLNSL
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: HPRK_XYLFT
Sequence: MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: RS11_NOSP7
Sequence: MARQPTKKSGSKKQKRNVPSGMAYIQSTFNNSIVTITDQNGDVISWASAGSSGFKGAKKGTPFAAQTAAESAARRAIDQGMRQIEVMVSGPGAGRETAIRALQGAGLEITLIRDITPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ISPE_CHLMU
Sequence: MHFFSPAKLNIFLQLLGKREDGFHEIVTRYQAVSFGDQLSLSVSSRDSFQIINDCQLEISNNSIWKSTALFRQYTGITDPVSWRVVKHIPIGSGLAGGSSNAATALFALNQMFQTGLSDEELRSLAEKVGMDTPFFFSSGSALGLGRGEKVVTLNELVVDRYILYFSNKGVLTSEAFAVVKPSDCSLSKDLEYARNDLENPVFRLRLDLKEKKRWLEDLWKGIPVYVGLTGSGATLFVRYPKALEKNSAYATQIQKIIALSGGVSTSPIQRDTPNWYPTILEA
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: YKT6B_XENLA
Sequence: MKLYSLSVLYKGENKVHLLKSAYDVSSFSFFQRSSVQEFMTFTSQLIVERSDKGSRSSVKEQEYLCHVYVRNDSLAGVVIADNEYPPRVCFTLLEKVLEEFSTQVDRIDWPSGSPATIQYNALDSYLSKYQNPRDADPMSKVQAELDETKIVLHNTMESLLQRGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCDIM
What is the function of this protein?
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment.  Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5.  Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5.  Has a S-palmitoyl transferase activity.
What are the official names of this protein?
Synaptobrevin homolog YKT6-B.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.
Protein: RNP2_META3
Sequence: MLKTLPPTIREKKRYISFKIIYNNELSGGEVVNLIRSSLINYYGVWGSSKCNPWLIDYTHPKGLLRITREEVDFVKSALISINEYKKNPINIIILGVSGTIKKSREKFLKVPHEKYYKVIQRRKKENSYKNRLRK
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 2, RNase P component 2, Pop5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_RHOOB
Sequence: MSEEKAVSTEERGSRKVRTGYVVSDKMEKTIVVELEDRVKHPLYGKIIRRTSKVKAHDENGVAGIGDRVQLMETRPLSATKHWRLVEVLEKAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: UREG_ACIBT
Sequence: MTERSPLRVGIGGPVGSGKTALTLNLCRALRDKYNMAVVTNDIYTKEDSNFLTRNEAMSPDRIVGVETGGCPHTAIREDASINLAAIDDLCEKFDGLELIIIESGGDNLAATFSPELSDLTLYVIDVAGGEKIPRKGGPGITKSDLLIINKTDLAPMVGANLDVMDQDAKRMRGEKPFLFSNMKTQDGLEEIIQFIEKQGLFKA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTE_SHEWM
Sequence: MLQALKESKDFLQLTLAQPQHFDETFTFMLGSHTQVEVWDTGVIVFEPKVARGKDIVLSCAVHGNETAPIELCNGLIKSLLEERLIAEQRVLFLFGNPPAIINGTRFIDENLNRLFNGAHSVGEGLVNPERIRAKKLEFYVDKFFSSSKDNSHKIHYDLHTAIRGSKHEKFAIYPYRPGRKYSGEQIMFLEACGIDTVLFHHEPTTTFSYFSSLNYQADAFTIELGKVLPMGQNDMTRFIALNEMLSRLIGNKSLELPDFNAKTVNLYQVCRAINKGFDDFEFTFANDVENFTSFPKGYILAKEGGENIKVEHEVEAIVFPNAKVPVGQRTVLCLKPASTENIDG
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: P4H4_ARATH
Sequence: MARRGLLISFFAIFSVLLQSSTSLISSSSVFVNPSKVKQVSSKPRAFVYEGFLTELECDHMVSLAKASLKRSAVADNDSGESKFSEVRTSSGTFISKGKDPIVSGIEDKISTWTFLPKENGEDIQVLRYEHGQKYDAHFDYFHDKVNIVRGGHRMATILMYLSNVTKGGETVFPDAEIPSRRVLSENKEDLSDCAKRGIAVKPRKGDALLFFNLHPDAIPDPLSLHGGCPVIEGEKWSATKWIHVDSFDRIVTPSGNCTDMNESCERWAVLGECTKNPEYMVGTTELPGYCRRSCKAC
What is the function of this protein?
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in proline-rich peptide sequences of plant glycoproteins and other proteins.  Hydroxyprolines are important constituent of many plant cell wall glycoproteins such as extensins, hydroxyproline-rich glycoproteins, lectins and arabinogalactan proteins.
What are the official names of this protein?
Probable prolyl 4-hydroxylase 4, AtP4H4.
What is the protein family that this protein belongs to?
Belongs to the P4HA family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: SELO_PSESM
Sequence: MKALDELVFDNRFARLGDAFSTHVLPEPIDAPRLVVASESALALLDLAPEQSELPLFAEIFSGHKLWAEAEPRAMVYSGHQFGSYNPRLGDGRGLLLGEVYNDAGEHWDLHLKGAGRTPYSRMGDGRAVLRSSIREFLASEALHALGIPSSRAACVVSSNTPVWREKQEYAAMVLRLAQSHVRFGSLEYLFYTKQPEHLKTLAEHVLTMHYPHCQEQPEPYLAMFREIVERNAELIAKWQAYGFCHGVMNTDNMSILGITFDFGPFAFLDDFDEHFICNHSDHEGRYSFSNQVPIAQWNLSALGQALTPFVSVEALRETIGLFLPLYQAHYLDLMRRRLGLTVAQDQDDKLVSQLLQLMQNSGVDYTLFFRRLGDQPAAQALRALRDDFVDIKVFDDWAQAYQARIAAEENGTEQARKERMHAVNPLYILRNYLAQNAIEAAEKGDYEEVRRLHQVLCTPFTEQPGMEGYAQRPPDWGKHLEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: TMCAL_STRZJ
Sequence: MTITGIIAEFNPFHNGHKYLLDQAEGLKIVAMSGNFMQRGEPAIVDKWTRAQMALENGADLVVELPFLVSVQAADFFGQGAVNILDRLGIDSLVFGTEEVRDYQKIADLYTEKGAEMEKFVENLPDSLSYPQKTQAMWKEFAGLDFSGNTPNHVLALAYAKAVAGRNIKLHPIQRQGAGYHSVNKDVDFASATALRQHQKDQDFLERFMPSVALFEQASKVIWEDYFPLLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSVEELVELVTTKRYTKARVRRLLTYILMQARENVLPEAIHVLGFTEKGRQHLKSLKGQVSLVSRIGKEPWDAMTQKADQIYQLGNPSIAEQNFGRVPIRIETN
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_PROM5
Sequence: MSSIFGKIFRVSTFGESHGGAVGVILDGCPPKLKINIDLIQNELDRRRPGQSKITTPRKEDDKLEILSGLKEGITLGTPIAMLVRNKDQRPEDYNNLEQVFRPSHADGTYHLKYGIQAGSGGGRASARETIGRVAAGAIAKQLLKTLFNTEILSWVKRIHDIDSQVNKNKLTLSKIDSNIVRCPDEKVATKMIQRIKELQQEGDSCGGVIECLVKNVPSGLGMPVFDKLEADLAKALMSLPATKGFEIGSGFLGTYLRGSEHNDSFVESDDINKLKTKSNNSGGIQGGISNGENIEMKIAFKPTATIGKEQKTVNSDGKEIVMKAKGRHDPCVLPRAVPMVDSMVALVLADHLLLHQAQCSIIK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: HIS2_LISMO
Sequence: MLNDLYEEIKLRKTQPREGSYTNYLFDKGLDKILKKVGEEATEVVIAAKNDNQELIAEVSDLAYHLLVLLAEKNIPLVAIQTELQKREGKLSTTRDRKEINDL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTCB_THEAN
Sequence: MTKTYKYEDQLHFIQKSDDVKNLFIIKKGFVPNMNVEGHLFANDNLSKLLFDELKQFTDDPGSFLPALKQLANVAALPGIVKSSIALPDAHSGYGFSIGNVAAFDMDNCNSIVSPGGVGFDINCGVRLLRTNLLYKDIEPIKEQLVQKLFDLIPVGVGCQGKIPCDYGDLDNILEYGMDWSVCSGYSWAEDKEHCEDFGRMIQADPTVVSYRAKKRGLSQIGTLGAGNHYGEVQVSIYSNIYVVEEIYDEYSAKVMGIDRIGQVCIMTHSGSRGLGHQVASDALVDMENSLNKSKIKVNDKQLACARINSDEGKKYLKGMAAASNYAWVNRSVMTHLTRKAFEEVLKESADDLDMHVVYDVSHNIAKIEDHMVDGKLKRLLLHRKGSTRAFPPYHPLISADFQHIGQPVLVGGTMGTCSYVLTGTQLAMDLTLGSTCHGSGRTLSRNKSRRVLDYNEVLNNLKEKGISIRVASPKLVTEEAPESYKDVSEVVQTCHDSGISKKCVKLRPVAVIKG
What is the function of this protein?
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.  May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
What are the official names of this protein?
RNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
Protein: NPBW1_BOVIN
Sequence: MHNASYWGPERANTSCPAPAPTLGCPNASGPAPPLPPPLAVAVPVVYAVICAVGLAGNSAVLFVLLRAPRRKTVTNLFILNLAVADELFTLVPPVNIADFLLRRWPFGELLCKLVVAVDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYGAARAVSLAVWGVATLVVLPFAVFARLDEEQGRRQCVLVFPQPEALWWRASRLYTLVLGFAIPVSTICVLYTSLLCRLRAIRLDSHAKALDRAKKRVTVLVVAILAVCLLVWTPYHLSTVVALTTDLPQTPLVIAVSYFITSLSYANSCLNPFLYAFLDDSFRRSLRQLLACRTTS
What is the function of this protein?
Interacts specifically with a number of opioid ligands.  Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity).
What are the official names of this protein?
Neuropeptides B/W receptor type 1, G-protein coupled receptor 7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARGB_BURTA
Sequence: MSEPIDLSQISPSLKAEILAEALPYIRRYHGKTVVIKYGGNAMTEERLKQGFARDVILLKLVGINPVIVHGGGPQIDQALKKIGKQGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVTLINHFGGHAVGLTGKDGGLIHARKLMMPDRDNPGEYVDIGQVGEVEAINPAVVRALQDDAFIPVISPIGFGEDGLSYNINADLVAGKLATVLNAEKLVMMTNIPGVMDKEGNLLTDLSAREIDALFEDGTISGGMLPKISSALDAAKSGVKSVHIVDGRIEHSVLLEILTEQPFGTMIRSH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_PARL1
Sequence: MSAKKSASKATVTVQQIGSPLRREPSQRQTLIGLGLNKMRRTKTLEDTPAVRGMINKVAHLVRVVDEA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: MCR_SAIBB
Sequence: METKGYHSLPEGLDMERRWGQVSQAVEHSSLGSTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKHELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYYEQQNQQRSMSPAKIYQNVEQLVKFYKENGHRPSTLSCVNRPLRSFMSDSVSSVNGGVMRAIVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTSRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSPFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGTCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSAISRALTPSPAMVLENIEPEVVYAGYDNSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFIRLQLTFEEYTIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVNDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
What is the function of this protein?
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol.  Binds to mineralocorticoid response elements (MRE) and transactivates target genes.  The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity).
What are the official names of this protein?
Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of ligand, nuclear after ligand-binding.
Protein: PRSA_STRPJ
Sequence: MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKNNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAGMTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAKEVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGVSDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIGKELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: YABQ_ECOLI
Sequence: MNGATSLYDEVIIINKIPPKKIDTKGVATEEVATKKVLLNKLLTTQLLNEPE
What is the function of this protein?
Identified as a multicopy suppressor of the slow growth phenotype of an rsgA (yjeQ) deletion mutant.
What are the official names of this protein?
Protein YabQ.
Protein: FADR_ECOSM
Sequence: MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR
What is the function of this protein?
Multifunctional regulator of fatty acid metabolism.
What are the official names of this protein?
Fatty acid metabolism regulator protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTBD8_RAT
Sequence: MAHCGAGGAAPAGLPRSPGLGRKGLPRKGSGERRRLKAVVSEQLSRDVLRLLREEMHTDMVLSVSGSLFKVHRAVLLARAPGFHSHITGHTSRGLTDELIPVDSVEASEFKAFLQIVYSSNKSVKNYEEEILQKMQVGNVMPEKGLDVSFLQCRTSSDCFLGKHEIPADVTSGGDSFISKDDCDLEPVSELGADLLKLYLSQDYHDIDICVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQECITLQGITHVEMSVMMHFIYGGTLDFPEKANVGQILNVADMYGLEGLREVAIYVLRRDYCNFFQKPVPRTWASILECLVIAHSVGVESLFADCMNCIISHFARFWSERSFANVPPEIQKTCLSMQIQSLNHGNAALLLMESDKLITGLPRVKWTEAALSMASQLQGECVTFIVQNFSQVMESASFTLLLQSQAMSSTAHLLDKIFKAIEDSITAENSCSLLMALDTLLKSDSAEEMGFTCRIQAVRDKLWTFLVQSFYAVRHTESWKLMHIDDQQKIQAAALDKGDDRRLGRKPVLSSSQQRRQGSDVIKIKPWTGNNKKLCRASPSTNEKMRSDGLGASGHASGTHRNSVNKVSKHGEGTKVSKVTTEVKTGATHVPGKPKTTIKPQTENNAHTKLESISSTVVGRPARMAATGRKDLAHGKGIQNQEGETTGARPKVLTANLNTQARAKPLQTVKGKDNGCSATVGPSSRSANSSMERLASTGSVDETKENGSVEDKSCDKKPYVSASPGQMVYNGVTSTVAVKSRPVSRVTSGTSSKKSFIHEQGPSVTSSVIKKGRGSSKGLNDSAPQTAAKRGGSSNGYAAAQPRTKSAPPTLAQTQGSQGESPHSVKSSISSRQSDESVTRLRHGTDKQMPKRKVVKQGHATLQKVNAKPTPKNPSQSTKGGTMTSKDSKQKVLPGQVTLQSQASQRPSNPEAATTQRSVLHGVNDNRSQVFKQRPPESLVNLASDTNGPEASPSPCRPQPQSPLGNQEKTRQEREHQDGSTLGDSVKHELRSELTSIEQSHTPAYKVSSQCSANPNCGCIASLKPVTSNPSENWINSNTANTDQVCVSDRERQTGRKGTDREPSVNCVARKAALPSVPAGMSGTLKSAQDDRKLPFHREELSAQGHLPHDCATEDSKCATPTSAVSSRCLLGQPSEKGYKNMEASGTSESHEAPEAPFMGPWDLNTSATHQRESPESDTGSATTSSDDIKPRSEDYDAGGSQDDEGSHDRGVSKCSTALCHDFLGRSSSDTSTPEELKVHEGDLRTEVRVRKPGGGDLPLHSASDDETPRKKPDPWSRSTIVHPREKGSAPRGSVPSAQEVDQVSSSADETEDERSEAENVREHSSPSNSGTQHVQGIINLAFEDGTEHESREFSATKKFRRSVLLSVDECEEVGSDEGEGHTPLQPSLDSLSPSDVFDGVSYEHHGRTGYSRFFKENEATTAEHKYSRGNDGHKNEGFLLSPRSRDFPRQGKQCVSTGEKTRLDVPPKASQQPFPESKDMTSKREVAHGLQQHGTLTDGDTRSQERPCHLELHQREPSSTIPKISSARSLDSCPSQVLPQDGQVTATHPTPPKRANNAVFSGDIDDCDTMAQTTMYDHRPSKTLSPIHEMSLTAACEQKEESGTHVADRASEDEQPFAKQDWTLLKQLLSEQDANLNVTSSLPEDLSLAQYLINQTLLLARDSSKPQGSAHADTWNRWSELSSPLDDLTASATTVSVSSTDCSPQGEWTILELETQH
What is the function of this protein?
Involved in clathrin-mediated endocytosis at the synapse.  Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
What are the official names of this protein?
BTB/POZ domain-containing protein 8, AP2-interacting clathrin-endocytosis protein, APache.
Protein: OTBP_DANRE
Sequence: MLSHADLLDTRLGMKDAAAELLVHREALKCRLGGTDSGHPGDLTSATETVEGTTLLPGEEISNGGSNPNGMQQVNAKDQEKQQQQNSNQTGGQQNQQKQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRAPGTLLPTHGLPQFPSAAAAAMGDSLCSFHANDTRWAAAGMPGVSQLQIPPSLGRQQAMAQSLSQCSLGAGPPPNNMGLSGSLSSNGSGLQSHLYQPTFPGMVPASLSGPTNVTGSPQLCSSPDSDMWRGTSIASLRRKALEHTVSMSFT
What is the function of this protein?
Involved in the specification of isotocin cells.  Required for the specification of dopaminergic neurons in the developing hypothalamus and posterior tuberculum.
What are the official names of this protein?
Homeobox protein orthopedia B.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAPZB_EMENI
Sequence: MADAQFDSALDLLRRLNPRDTKQNLQAITSIVPDLTEDLLSSVDQPLEIRRCPKTKRDYLLCDYNRDGDSYRSPWSNEFDPPLDDGTVPSERVRRLEVAANEAFDVYRELYYEGGVGSVYFWDLDDGFAGVILLKKGVSPGGKHSGEWDSIHVFEATDRGRMAHYKLTSTVILHLSNENEALGEMDLSGNMTRQIEVDMNVDSDASHVANVGKLVEDMELKMRNLLQEVYFGKAKDVVGELRSIGPLSETNRDRATHQEMIRGLQR
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit beta.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Note=Septum.
Protein: LIS1_MACFA
Sequence: MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLTSCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHLVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
What is the function of this protein?
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation.  Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity).  Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome.  Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate.  Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates.  During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules.  Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors.  May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.  Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos.  May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).
What are the official names of this protein?
Platelet-activating factor acetylhydrolase IB subunit alpha, Lissencephaly-1 protein, LIS-1, PAF acetylhydrolase 45 kDa subunit, PAF-AH 45 kDa subunit, PAF-AH alpha, PAFAH alpha.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus membrane. Note=Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes.