PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_STRP7
Sequence: MSRILDNEIMGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEAAKMRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELEPGDVLFIDEIHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTRAGMLSNPLRARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPRIANRLLKRVRDFAQIMGNGVIDDIITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: HIS5_DEHM1
Sequence: MIALVDYGGGNLKSVANAIHALGYEFKLTSSPEEILSAEAVILPGVGAAADTMAGLQSKGLDKAIKELVARDIPLLAICVGMQVLFDYTAEGDNTKCLGILKGDVKRLPEGLKIPQMGWNQLKQRVSHPIFEGIPDGIDFYFVHSYYASPADPGIIGATTDYGVDFCSLVISKRLIATQFHPEKSGSYGLKLYQNFFKMALGDKK
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGRC2_RAT
Sequence: MAAGDGDVKLSTLGSGGERGGDGSPGGAGATAARSSWVAALLATGGEMLLNVALVALVLLGAYRLWVRWGRRGLCSGPGAGEESPAATLPRMKKRDFSLEQLRQYDGARTPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHSKQD
What is the function of this protein?
Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan.  May serve as a universal non-classical progesterone receptor in the uterus.  Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus.  Plays a role in adipocyte function and systemic glucose homeostasis.  In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1.
What are the official names of this protein?
Membrane-associated progesterone receptor component 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family. MAPR subfamily.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein. Nucleus envelope. Endoplasmic reticulum.
Protein: SURE_CUPTR
Sequence: MHILLANDDGYLAPGLAVLHAALAPLGRITVIAPEQNHSGASNSLTLQRPLSVYEAREGVQKGFRFVNGTPTDCVHIALTGLLEDKPDLVVSGINQGQNMGEDVLYSGTVAAAIEGYLLGIPSVAFSQVDKGWEHLDAAARVARTVVERIIGTPPAEPFLLNVNIPNLPFEHIRGYRATRLGKRHPSQPVITQVNPRGDTNYWIGPAGDARDASEGTDFHATAQGYVSLTPLQLDLTHRGQLDALDQWLK
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBX48_MOUSE
Sequence: MKKTSKKNNNFKIPGTELNSADAERGKEESQRNFVELLPLEVTYKIFSQLDIQSLCRASRTCTGWNCAIRNNDSLWKPHCLTIRAVCQREIDDDIKSGYTWRVILLRNYQKSKVKYEWLSGRYSNIRSPVNLPEKAMCPMDADTWGEILDAELEREVEKLQ
What are the official names of this protein?
F-box only protein 48.
Protein: KHSE_BRASB
Sequence: MAVYTDVAADELADFLKTYDIGELLSYKGIAEGVENSNFLLHTTKGYFILTLYEKRVAVDDLPYFLGLMAHLAERGVSCPQPARNRDGAVYSTLSGRPAAIINFLEGLWPRKPNVAHCAGVGTALARMHLAGRDFPLVRKNPLSVSGWMSLFAQAADRADTVQAGLSALLSAELDVLARSWPTDLPEGVIHADLFPDNVFFLGDQLSGLIDFPFSCNDILAYDVAICLNAWCFEADHSLNVTKARAFFHAYGRERPLSQAELAALPLLARGAAIRFLLTRLVDWLNVPAGALVKPKDPLEYVRKLRFHQAVTSVRDYGLDGSGATA
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: ILVD_STAAT
Sequence: MRSDMIKKGDHQAPARSLLHATGALKSPTDMNKPFVAICNSYIDIVPGHVHLRELADIAKEAIREAGAIPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADAAETVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAIFCSGGPMKAGLSAHGKALTLSSMFEAVGAFKEGSISKEEFLDMEQNACPTCGSCAGMFTANSMNCLMEVLGLTLPYNGTALAVSDQRREMIRQAAFKLVENIKNDLKPRDIVTREAIDDAFALDMAMGGSTNTVLHTLAIANEAGIDYDLERINAIAKRTPYLSKIAPSSSYSMHDVHEAGGVPAIINELMKKDGTLHPDRITVTGKTLRENNEGKEIKNFDVIHPLDAPYDAQGGLSILFGNIAPKGAVIKVGGVDPSIKTFTGKAICFNSHDEAVEAIDNRTVRAGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKDVALITDGRFSGATRGIAVGHISPEAASGGPIALIEDGDEITIDLTNRTLNVNQPEDVLARRRESLTPFKAKVKTGYLARYTALVTSANTGGVMQVPENLI
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CH10_SALDC
Sequence: MSIRPLHDRVIVKRKEVESKSAGGIVLTGSAAGKSTRGEIIAVGKGRILDNGTVQPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO4_BACVZ
Sequence: MAGKGRIIFHIDMNSFYASVEMAYDPSLRGKPIAVAGNVKERKGIIVTCSYEARARGVKTTMPVWRAKRLCPELIVVPPNFDRYRSSSKEMFSILREYTDLVEPVSIDEGYMDITDTPHSHRAYETAEDIQARLQKELLLPSSIGIAPNKFLAKMASDMKKPLGITILRKRELPDVLWPLPIEEMHGIGTKTAEKIKTLGIKTIGDLAKGDEHALKTLLGINGPRLKDKANGIHPAEVNPERIYEFKSVGNSSTLSHDSADWDELTGVFDRLALSVSERLQRKEVMACRLFIMIRYADWKTVTRSMTLSNPADQKKDIMEAAMELFDKHWNQNPVRLLGITGTELVEKQQAYKQLDLFSFKEDAKDEPIFQMMNELNEKYGQNLIRKGAVIKKEESKTRGTSFNRDFFQDEKKR
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_STRAW
Sequence: MEARAQARYIRVTPMKARRVVDLIRGMDATEAQAVLRFAPQAASVPVGKVLDSAIANAAHNYDHTDADSLFISEAYVDEGPTLKRFRPRAQGRAYRIRKRTSHITVVVSSKEGTR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL11_DESA1
Sequence: MVKKTIRVMVEGGKATPGPPLGPTLSPYKVNIPQVVKAINDATKDFEGLSVPVEITIDIDTKEFEVRVGIPTTTALLMKEAGAKQPTGDPAHQKIGNISFEQVVKVAILKRDSLTAKTLRAAVKTVLGTARSIGITVDGKDPKEVQKLVDEGVYDEILSRYEEEWSKGGQ
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ACP_BACC4
Sequence: MADVLERVTKIIVDRLGVEETEVVPAASFKEDLGADSLDVVELVMQLEDEFEMEISDEDAEKIATVGDAVTYIESHL
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPPC1_MOUSE
Sequence: MTVHNLYLFDRNGVCLHYSEWHRKKQAGIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLSFQTSRYKLHYYETPTGIKVVMNTDLGVGPIRDVLHHIYSALYVEFVVKNPLCPLGQTVQSELFRSRLDSYVRSLPFFSARAG
What is the function of this protein?
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
What are the official names of this protein?
Trafficking protein particle complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. BET5 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
Protein: FBL69_ARATH
Sequence: MDAKMFDTICSRDAISWLPDEVLGKILSLIPTKQAVSTSLLAKKWRTIFRLVDHLELDDSFSLQAVKDQTPGLRKHVRFVFTEDFKIFVDRTLALQCDYPIKNFSLKCHVSKYDERQKACVGRWISNVVGRGVFELDLRMKDPGIHFLPPHLVASKTLVKLTLGTQLCLGQLPSYVSLPSLKSLFIDTIVFYDIEDLCCVLLAGCPVLEELSVHHHDFIATPHTISSPTLKRLSVDYHCPDDVDSASHMSFDLPKLVYLEYSHCALGEYWQINLESLVEAKLDLGLERKVLRMDVTDLIIGIRNVQSLHLSPDSVHVIYSYCRHGLPVFKNLVNLSFGSKNKRGWRLLANLLKQSTKLETLIVKDLNGYTGDVSMPLNKVTSLHILGYRGTADEVKQLKSFIGEFECLELVQVDVAEAAEDNGKILQSKRDLMMLLGVSLPSKCQFKVT
What are the official names of this protein?
F-box/LRR-repeat protein At3g60040.
Protein: PLSB_SHEHH
Sequence: MSKQDSLWFKSLRWLQRKLVHTVVVPHDPFDDLNLDPSKPLVYVMKTESVSDIAALSEMTEKLGLPSPYEELEVNGIRAPRVVCLEGSKPLFGQREGGEQYIDYFKRLLSVHKQNLELDIQLVPVSLYWGRTPGKEDDTMRAAVLERQNPTWLRKCLMILFLGRHNFVQFSNAVSLRYMADEHGTDKRIAQKLARVARAHFERQRKVMTGPQLPKRQALFHALLKSDSITKAIKEEAASKKISESEARAKAMEYLDEVAADYSDSLVRIAERFLTWLWNKLYKGINIKGAEQVRQLHHDGHEIVYVPCHRSHMDYLLLSYILYYQGMVPPHIAAGINLNFWPAGPAFRRGGAFFIRRSFGGNKLYTAVFREYLDQLFTKGYSVEYFTEGGRSRTGRLLAPKTGMLAMTLNSVLRGVERPVTLVPVYLGYDHVMEVATYHKELSGKKKKKESVWQIFGAIRKLGNFGQGYVNFGEPITLHNFLNEQVPSWRDDIAKDPDQKPTWLTPVVNTLANQVMTNINDAAAVSSVTLTSMVLLASEQNALERSQLEKQLDLYLTLLKERPYTDYTSVPDGTGHDLVSQGLELKKLQIESDPLGDIISIDQSIAITMTYYRNNIIHLMVLPSLIAACLLRKENCGRNDVISIVNDFYPLLEAELFMGIEDPSQYANQILDILVAQGLVVECDHFEVVDSSINQLLLLSGTISETMQRYAILFNLLEVKPNMERSELEKDSHRLAQRLGALHGITAPEFYDKKLYATLSVKLKELGYLTDNQGCSDIKRIKERANLLLRSSVKQTIVDSVHAEHIA
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATPL_ECOLC
Sequence: MENLNMDLLYMAAAVMMGLAAIGAAIGIGILGGKFLEGAARQPDLIPLLRTQFFIVMGLVDAIPMIAVGLGLYVMFAVA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYDND_RICB8
Sequence: MHKYRTHNCNELKISDVGAEVKLSGWVHRRRDHGNLVFVDLRDHYGITQIVFTDQNPQLMDDASRLRYESVVTVIGKVVARSEETINNTLPTGHIEVLAGEFIVESAADTLPFVINTEKDAPEDSRLKHRFLDLRREKLHNNIMLRSQIISYIRQLMTARGFTEFQTPILTASSPEGARDFLVPSRLHPGKFYALPQAPQQFKQLLMVSGFDRYFQIAPCFRDEDARADRSPGEFYQLDIEMSFVTQEDIFSTIEPVMYELFTKFTDKKVSEAPFIRIPYNESMLKYGSDKPDLRNPIVIADVTEIFRDSDFTIFRENIKKGSIVRAIPAPYAAAQPRSFFDKMIEFAISEGAGGLGYIQFSETGEAKGPVAKFLSTQQLEDLKATANISNGDAVFFASDKKDKAAKLAGKVRIKLADELDLLEKDCFKFCWITDFPFYELNEETGKIDFSHNPFSMPQGGLEALENAKTTEELLELTAYQYDIVCNGIELSSGAVRNHKPEIMYKAFAIAGYSEEEVDKRFGGMIRAFKFGAPPHGGIAPGIDRIVMLLAEATNIREIIAFPLNQQAEDLLMNAPNYVEDKALKELNVMLSPSARKNAEKE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_HAEIG
Sequence: MDLYAVWGNPIVQSKSPLIQNKLATQTHQTIEYIAKLGDLDAFEQQLLAFFEEGAKGCNITSPFKERAYQLADEYSQRAKLAEACNTLKKLDDGKLYADNTDGIGLVTDLERLNWLRPNQRVLILGAGGATKGVLLPLLQAQQNIVLANRTFLKAKELAERFQPYGNIQAASMDSIPLQTYDVVINATSAGLSGGTAPVDAEILKLGSAFYDMQYTKGTDTPFIALCKSLGLTNISDGFGMLVAQAAHSFHLWRGVMPNFVAVYEQLK
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: CP80_BP186
Sequence: MADAMDLAQLREQEDRERHISNARSRRHEVSAFICEECDAPIPEARRRAIPGVQCCVTCQEILELKSKHYNGGAL
What are the official names of this protein?
Uncharacterized 8.5 kDa protein in gpA 5'region.
Protein: ZN821_HUMAN
Sequence: MSRRKQTNPNKVHWDQVFAGLEEQARQAMMKTDFPGDLGSQRQAIQQLRDQDSSSSDSEGDEEETTQDEVSSHTSEEDGGVVKVEKELENTEQPVGGNEVVEHEVTGNLNSDPLLELCQCPLCQLDCGSREQLIAHVYQHTAAVVSAKSYMCPVCGRALSSPGSLGRHLLIHSEDQRSNCAVCGARFTSHATFNSEKLPEVLNMESLPTVHNEGPSSAEGKDIAFSPPVYPAGILLVCNNCAAYRKLLEAQTPSVRKWALRRQNEPLEVRLQRLERERTAKKSRRDNETPEEREVRRMRDREAKRLQRMQETDEQRARRLQRDREAMRLKRANETPEKRQARLIREREAKRLKRRLEKMDMMLRAQFGQDPSAMAALAAEMNFFQLPVSGVELDSQLLGKMAFEEQNSSSLH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 821.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NPR1_YEAST
Sequence: MSSLTRLLQEKRKNETSNSSPRTSADTLTTTPESQSLDLHSRNKSSSHIGSVSNSSSSDRNRANVPVPGSVTTVTQIYSEEDSSSTAGSSLDDRNQFSSSFLNANFAHTASFYGTSAQSRDRFGSLINDQGTAGLSSHGGSFAAQNRITSRLSTTSHTSGRAIPSLSSSIPYSVPNSNKDNNSSNSNSSSLSSSWLETYAGGMPNNISAIDSNVISSPKVDSVEPRFVISKQKLQKASMDSNNANATQSRSISRSGSFSSQLGNFFFSKNSKESSNSNSAGMSFSANSNGPSPNIKNPNVTNGSTPIPKPIRARQSSIYSASRQPTGSYTDNFYGSPSSVHDHLPPSQSVPRSQHSSIGDLKRFFKKSSNSNLSSNSNNVIPNGSPLSSGIAVPSHSHSSSHFAAGNNSYSTSYNGNGDTIYSHSHGGSGIPFSKRYIKTGADLGAGAGGSVKLAQRISDNKIFAVKEFRTKFENESKRDYVKKITSEYCIGTTLNHPNIIETIEIVYENDRILQVMEYCEYDLFAIVMSNKMSYEEICCCFKQILTGVQYLHSIGLAHRDLKLDNCVINEKGIVKLIDFGAAVVFSYPFSKNLVEASGIVGSDPYLAPEVCIFAKYDPRPVDIWSSAIIFACMILKKFPWKIPKLRDNSFKLFCSGRDCDSLSSLVTRTPDPPSYDESHSTEKKKPESSSNNVSDPNNVNIGPQRLLHSLPEETQHIVGRMIDLAPACRGNIEEIMEDPWIRSIDMCHLVEDGLSFKVVRGEDHHHTQVDQSEAHIAGLEKKKKKQNNQ
What is the function of this protein?
Nutrient-regulated protein kinase that promotes the activity of at least 6 distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression.  Under poor nitrogen growth conditions, required for post-Golgi sorting of the general amino acid permease GAP1 and the three known ammonia permeases, MEP1/2/3, to the plasma membrane.  Contributes also to the stability and the retention of GAP1 at the plasma membrane.  Inversely, promotes the degradation of tryptophan permease TAT2 under the same conditions.  Activity is regulated by the TOR signaling pathway via phosphatase SIT4.  Although thought to be involved in regulation of GLN3-dependent transcription by nitrogen catabolite repression, this seems to be an indirect effect from the reduced uptake of the nitrogen-repressing compound.
What are the official names of this protein?
Nitrogen permease reactivator protein, Serine/threonine-protein kinase NPR1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Appears to be more concentrated in punctate structures reminiscent of the Golgi or of an endosomal compartment.
Protein: ATPA_DECAR
Sequence: MQLNPSEISELIKSKIQNLQGASEVRTQGTVVSVTDGICRVHGLQDVMQGEMLEFPGNTFGMALNLERDSVGAVVLGEYEHISEGDIVKTTGRILEVPVGPELLGRVVNSLGQPIDGKGPINAKLTDKIEKVAPGVIWRQSVSQPVQTGLKCVDSMVPVGRGQRELIIGDRQTGKTAVAVDAIINQKGKGLFCVYVAIGQKASTIANVVRKLEEHGAMEYTIVVAAPASESAALQYLAPYAGCTMGEYFRDTGEDALIIYDDLTKQAWGYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVSAAWVEKLSNGAIKGKTGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETDLFNAGIRPAINAGISVSRVGGAAQTKLIKKLGGGVRLALAQYRELAAFAQFASDLDEATRKQLERGRLVTELMKQPQYSPMSISEMAVTLYAADKGYFDDVEVKRALECEKAMIGYLKTNCADLMKTMESTADLSADSEKQLAAGIAAFKSSWV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DTN1_CAEEL
Sequence: MLWSNGGGGPREPSSAPSPDHHRAMHSVPPIVASEMQQLIDEMRLQDFDSIRFATYRAACKLRFIQQKTKVHLVDIWNMIEAFRENGLNALPLHTVIKTSRAELLLTTVFHNLNKRLVASQHVDTDVSISLLLAFLLGAYDKQNTGRLTVFSIKVALATLCAGKLVDKLRYIFSQIADSNGLMDHIKFTDFLQQILSLTTAVFEAPTFGFSENAVNQCFHKDEKVSLNVFLDTFLSDPCPPCIMWLPLLHRMASVSNVYHPVVCDACQVRSFTGFRYKCQRCANYQLCQSCFWRGRTSQNHSNEHEMKEYSSYKSPTKQLVHSIHKSLQCIPATSTVGDANIDIFNAKIGGPVSSKPARPLNLNNIVPATPTTIRRQHAATSSADWPTSPVLLPGQASHGGVIDDEHKLIARYAAKLSGRADYPLSNGRSMNSSMVGDERTLIAQLEEENSMMVREMARLESQTTSDDGLAGLRDRKMELEEKMFEMQQRRRELMMQLEHLMAQLNTGPQPSGGVSSASLSQLPFTASDQQLTGVNSTVANAFRAGSLPATSLQGDLLHAADQITTNMSDLVRQLDLAQSDENGVTINGF
What is the function of this protein?
Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance.
What are the official names of this protein?
Dystrobrevin-1.
What is the protein family that this protein belongs to?
Belongs to the dystrophin family. Dystrobrevin subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_DECAR
Sequence: MLLHPQFDPVAFSVGPLSVRWYGLMYLVAFVQFIFLGRYRIKTRPGFLSVEQLDDLLFYGMLGVILGGRLGQVLFYEPAYFLANPLEIFAVWKGGMSFHGGFLGVLVAMGLWTRKHHLNWFEVMDFVAPLVPLGLAAGRVGNFINGELWGRVADASLPWAMIFPQSGDMQPRHPSQLYHVGLEGLALFVILWWFTAKPRPRAAASGAFLIGYGAFRFITEYFREPDHGIFGQSYTISMGQWLSLPMILIGVAMVVFAYRKKSL
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WBNK_ECOLX
Sequence: MYSCLSGGLGNQMFQYAAAYILQRKLKQRSLVLDDSYFLDCSNRDTRRRFELNQFNICYDRLTTSKEKKEISIIRHVNRYRLPLFVTNSIFGVLLKKNYLPEAKFYEFLNNCKLQVKNGYCLFSYFQDATLIDSHRDMILPLFQINEDLLNLCNDLHIYKKVICENANTTSLHIRRGDYITNPHASKFHGVLPMDYYEKAIRYIEDVQGEQVIIVFSDDVKWAENTFANQPNYYVVNNSECEYSAIDMFLMSKCKNNIIANSTYSWWGAWLNTFEDKIVVSPRKWFAGNNKSKLTMDSWINL
What is the function of this protein?
Involved in the assembly of the O-repeating unit during O-antigen biosynthesis.
What are the official names of this protein?
O-antigen biosynthesis glycosyltransferase WbnK, GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 11 family.
Protein: TRMFO_PELTS
Sequence: MTGRTVTVVGAGLAGAEAAWQAARRGIKVKLYEMRPEKLTPAHRSGYFAELVCSNSLRAAALENAVGLLKEEMRHLDSLVMACADVTSVPAGGALAVDRDLFARCVTERIAGNPLIEICREEVTAIPEGEAVIIATGPLTSDALASDISRFTGENCLFFYDAVAPIVAAESINMGKVFRSSRYGKGEAAYLNCPLSREEYEVFWEALVKAEKAPRKEFEKELHFEGCMPVEVLAARGKETLLYGPMKPVGLIDPRTGRRPYAVVQLRQENAAATLFNMVGFQTGLKWDEQKRVFRLIPGLEEAEFVRFGVMHRNTFINSPVLLHPTFQTRKNPALFFAGQITGVEGYVESAASGLMAGINAARLLAGKEPLVFPRNTAHGSLAHYITAADPAHFQPMNINFGLFPPFEARIRDKKERYRTVAKKALESIDRFKETLL
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPC19_MYCTU
Sequence: MKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLARRYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase (By similarity).  Upon expression in M. smegmatis inhibits colony formation.  Its toxic effect is neutralized by coexpression with cognate antitoxin VapB19.
What are the official names of this protein?
Ribonuclease VapC19, RNase VapC19, Toxin VapC19.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
What are the subcellular locations of this protein?
Secreted. Note=Following 6 weeks of nutrient starvation.