PharMolix/UniProtQA huggingface dataset:
Protein: PHLC_CLOHA
Sequence: MNKKKILKFICSAVLSFTLFSGYKSYAWDGKVDGTGTHALIVTQAVEILKNDVISTSPLSVKENFKILESNLKKLQRGSTYPDYDPKAYALYQDHFWDPDTDNNFTKDSKWYLAYGINETGESQLRKLFALAKDEWKKGNYEQATWLLGQGLHYFGDFHTPYHPSNVTAVDSAGHTKFETYVEGKKDSYKLHTAGANSVKEFYPTTLQNTNLDNWITEYSRGWAKKAKNMYYAHATMSHSWKDWEIAATETMHNVQIGSAGIIYRFLNEVSGTINTTENSKINEIMVVIKTANEDKAGTDHYIHFGIEAKDGKKYEWTLDNPGNDFEKNQEDSYRINLKDNKLTLQDIAKTWIRKERGAGVRDDWKPEYVKVIINSDVKYQANINEWFGDNKTFYINNK
What is the function of this protein?
Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture.  Binds to eukaryotic membranes where it hydrolyzes phosphatidylcholine, sphingomyelin and phosphatidylethanolamine.  The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage (By similarity).
What are the official names of this protein?
Phospholipase C, PLC, Beta toxin, Phosphatidylcholine cholinephosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the bacterial zinc-metallophospholipase C family.
What are the subcellular locations of this protein?
Secreted.
Protein: HBL2_GOSHI
Sequence: MGFTEKQEGLVKESWEVLKQDIPHSSLRFFSLILEIAPGAKNMFSFLRESEEIPQNNPKLKAHAVKVFKMTCESAIQLREKGEVVVADTTLKYLGTVHVKSGVKDPHFEVVKEALLRTIEEAIGEEKWNEEMKNAWGEAYDQLAEAIKAEMKNHHDETA
What is the function of this protein?
May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule.
What are the official names of this protein?
Non-symbiotic hemoglobin 2, GOShi GLB2, Hb2.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: MSRA2_STAAN
Sequence: MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNKTGHVEAVQITFDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQGIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA 2, Protein-methionine-S-oxide reductase 2, Peptide-methionine (S)-S-oxide reductase 2, Peptide Met(O) reductase 2.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: Y3603_ACIAC
Sequence: MMADTLEIVLITGMSGSGKSVALHALEDAGYYCVDNLPPELLAAFVALEHQHHGNRVAIAMDVRSATALPLVPQQLRRLRGEGVTVHSLFLDATTDTLVRRFSETRRRHPLSRDEWYGEPHALLETLELERELLADLREQSHVIDTSAIRAAQLQGYVKSLMPALPGQLTLVFQSFAFKRGVPVDADYVFDVRMLPNPHYEPGLRNLTGKDQPVVHYLEQAREVRQMREHITHFLGHWLEPLAQNHRSYVTVAIGCTGGQHRSVYLVEQLAAEFSDRWTTLRRHRELDGR
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Aave_3603.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: FGFR1_MOUSE
Sequence: MWGWKCLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLVESNRTRITGEEVEVRDSIPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMLGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSIPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPTQLANSGLKRR
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration.  Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.  Phosphorylates PLCG1, FRS2, GAB1 and SHB.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2.  In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription.  FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).
What are the official names of this protein?
Fibroblast growth factor receptor 1, FGFR-1, bFGF-R-1, Basic fibroblast growth factor receptor 1, MFR, Proto-oncogene c-Fgr.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus. SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane; Single-pass type I membrane protein.
Protein: TBB_PESMI
Sequence: MREIVHLQTGQCGNQIGAAFWQTISGEHGLDSNGVYNGTSELQLERMSVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEACDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMFDPKNMMAASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTAIQELFKRIGEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDAGVDEEEEEYEEEPLPEDE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y070_OSHVF
Sequence: MATLSDVFHFAKRCRLDSEFSEVIDSCCYHCIEGLNGVDMGTRELVIFLQRFVPRPVIDSPKPDMVLVEKLVHAHTVYRGCKAEKCEIVKRMVNYLFEVKPKSPALKEYIYKNSETMDIGDYWFDDEMYDIIISNLDWQRTRYTADNVHSCYFLLNTHTSKMCMKKARAAMSRLMSPTTLLVIPWFWKRLNHKMSQKHTM
What are the official names of this protein?
Uncharacterized protein ORF70.
Protein: GALE_PASMU
Sequence: MAILVTGGAGYIGSHTVVELLNANKDVVVLDNLCNSSPKSLERVAQITGKQVKFYQGDILDTALLQKIFAENQIQSVIHFAGLKAVGESVQKPAEYYMNNVTGSLVLIQEMKKAGVWNFVFSSSATVYGDPEIIPITESCKVGGTTNPYGTSKFMVEQILKDIAKATPEFSITILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLPQLSVFGSDYETHDGTGVRDYIHVVDLAIGHLKALDRHEGDAGLHIYNLGTGSGYSVLDMVKAFEKVNDIKIPYKLVDRRPGDIATCYSDPSLAKTELNWTAARGLEQMMKDTWHWQKKNPKGYRD
What is the function of this protein?
Involved in the metabolism of galactose.  Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
What are the official names of this protein?
UDP-glucose 4-epimerase, Galactowaldenase, UDP-galactose 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: STING_DROME
Sequence: MAIASNVVEAGNAVRAEKGRKYFYFRKMIGDYIDTSIRIVATVFLADLLLRLYRCVVEYGSNGRYYLPEDRLWIILRRSCTYNNRSIYLIVGFLLVAFFRISVTGNYRNVMPTTLFLFQMPLYWIWSFTDMDQSTLSYSHWIRDSHGLDYAAGMASNYFHGYLKLSLPERKDDGLKHRLAMYEDKNNVTFGIKRLVILIPDEMFVNGVLESHLLDKAEPLETQFINRAGVYRPFKHDVYRMNKKVNGRTYYFAVEGATPMISFFDATYSNLSGTWQMQELKREIWIKFYKHLKELITTWPETRDLVELIIYNSHDSKGNLVDVGELLVAHMQNKTKTIDEISN
What is the function of this protein?
Facilitator of innate immune signaling that binds cyclic dinucleotides produced in response to infection by bacteria and/or viruses, and promotes the activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:29934091, PubMed:29924997, PubMed:30119996, PubMed:33262294, PubMed:34261127, PubMed:34261128).  Recognizes and binds cyclic di-GMP (c-di-GMP), a cyclic dinucleotide messenger produced by bacteria such as L. monocytogenes, leading to activation of the peptidoglycan recognition protein (IMD) signaling pathway and activation of Rel (Relish) (PubMed:29924997).  Innate immune response is triggered in response to double-stranded RNA from viruses delivered to the cytoplasm: Sting acts by specifically binding cyclic dinucleotides 3',2'-cGAMP and 2',3'-cGAMP produced by cGlr1 and cGlr2 in response to RNA virus in the cytosol (PubMed:34261127, PubMed:34261128).  Has a strong preference for 3',2'-cGAMP compared to other cyclic dinucleotides such as 2',3'-cGAMP or 3'3'-c-di-GMP (PubMed:34261127).  Upon binding to 3',2'-cGAMP, activates an antiviral immune response, leading to the activation of Rel (Relish) (PubMed:34261127, PubMed:34261128).  Activated in brain in response to Zika virus infection, leading to autophagy (PubMed:29934091).
What are the official names of this protein?
Stimulator of interferon genes protein homolog, dSTING, dmSTING.
What is the protein family that this protein belongs to?
Belongs to the STING family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: KDSA_KORVE
Sequence: MIEPFKVKDVEIGGPKLFLIAGPCVIESEAHAMKMAEAISGVCKAMKIPYIFKASYDKANRTSLSSFRGPGLHEGLRILAKVADEVNVPVLTDVHDTEQATAAGDIVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFVAPNDMQYAVTKVRESGNQRVCLTERGASFGYNNLVVDMRALPIMRQFAPVIFDATHSVQLPSAGKDGHAVSGGQPEFIPVLSRAAVAAGVDGVFMEVHDDPPHAKSDGANALDLKLLRGVLTSLLRIREAVTPPAAS
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRK40_ARATH
Sequence: MGKCSALMIFLSSSLLLVLQTLHVVNAVKCFGNSFNGNSSTFAQNRQKLFPTLADKVIINDGFYNASLGQDPDKVYALVSCARGYDQDACYNCVQSLTQNTLTDCRSRRDSFIWGGNDDVTCLVRSSNQSTFGSVQLKPPVVWPSPDTIESSKNITLFKQQWEEMVNRTLEAATKAEGSSVLKYYKAEKAGFTEFPDVYMLMQCTPDLSSRDCKQCLGDCVMYFRKDYMGRKGGMASLPSCYFRWDLYSFHNAFDNVTRVPAPPPRPHAQEKESCITVKKGKSIGYGGIIAIVVVFTFINLLVFIGFIKVYARRGKLNNVGSAEYSDSDGQFMLRFDLGMIVMATDDFSSENTLGQGGFGTVYKGTFPNGQEVAVKRLTKGSGQGDMEFKNEVSLLTRLQHKNLVKLLGFCNEGDEEILVYEFVPNSSLDHFIFDEDKRSLLTWEVRFRIIEGIARGLLYLHEDSQLKIIHRDLKASNILLDAEMNPKVADFGTARLFDSDETRAETKRIAGTRGYMAPEYLNHGQISAKSDVYSFGVMLLEMISGERNNSFEGEGLAAFAWKRWVEGKPEIIIDPFLIENPRNEIIKLIQIGLLCVQENSTKRPTMSSVIIWLGSETIIIPLPKAPAFTWIRSQSESGAMSLSDDVFTELSCR
What are the official names of this protein?
Cysteine-rich receptor-like protein kinase 40, Cysteine-rich RLK40.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PAR3L_HUMAN
Sequence: MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMTAAV
What is the function of this protein?
Putative adapter protein involved in asymmetrical cell division and cell polarization processes.  May play a role in the formation of epithelial tight junctions.
What are the official names of this protein?
Partitioning defective 3 homolog B, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein, PAR3-beta, Partitioning defective 3-like protein, PAR3-L protein.
What is the protein family that this protein belongs to?
Belongs to the PAR3 family.
What are the subcellular locations of this protein?
Endomembrane system. Cell junction. Cell junction, tight junction. Note=Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions.
Protein: MURA2_HALH5
Sequence: MEKLMIEGGTPLEGTVQISGAKNSAVALIPAAILADSTVTIDNLPDISDVRLLGELLKEIGGEVELADQKMVIDPSKMFAMPLPNGRVKKLRASYYLMGAMLGKFKKAVIGLPGGCNLGPRPIDQHIKGFEALGAKVTNEQGAIYLRADELKGARIYLDVVSVGATINIMLAAVLAKGRTIIENAAKEPEIIDVATLLTSMGARIKGAGTNVIRIDGVESLHGCRHSIIPDRIEAGTYMILAAAIGQNVLIDNIIPLHVESLIAKLREMGVDVEVLDDQVRIRNHQEKKGVDIKTLVYPGFPTDLQQPATTLLTQAHGTSIVTDTIYNARFKHIDELRRMGADIKVEGRSAIINGKTKLQGAKVRASDLRAGASLVIAGLTAEGITELSGVEHIDRGYEDLEQKLIGLGAKIWREQMSDQEEEQVKSS
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2, Enoylpyruvate transferase 2, UDP-N-acetylglucosamine enolpyruvyl transferase 2, EPT 2.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
Protein: RLMH_STREM
Sequence: MKIKLICVGKLKEAYLRDGIAEYQKRLSRFCQCDIIELADEKTPDKASDAEKQQIMAKEADRIKKKLGQRDFVIALAIEGKQLASEQFSHLLSEVTVKGYSDIAFVIGGSLGLDQSIKNRANLLMSFGLLTLPHQLMRLVLIEQVYRAFMIQQGSPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_FRATT
Sequence: MYTKDTIVAIATPQGNGGIGIIRISGIDALAIAEKLTKKQLKPRYATFCNVYNDNEIIDHGIIIFFKAPLSYTGEDVVEIQAHGNPFILNLIIKAALNCGARMAKAGEFTERAFLNNKLDLAQAEAVADIINASSEIAAKSAAKSLQGDFSKEINNLLEKLIYLRMYVEASIDFPEEEINFLEDQKIHSSLEEIYKVILAVKNSCKQGVILAEGITLILVGKPNAGKSSLLNALAGKESAIVTSIAGTTRDIVKEHIQINGVPMHIIDTAGLRNSDDIIESEGIKRAIKKIQEADQVLFVTDDYTNSQVKFSDIKEIIPEFYDQIPKDIDITYVHNKIDLLKEVPHNHANHIYISAENNIGIDKLKEHILNKVGYTNQNESIYTARERHVTAINNAFEHIKLAKEQLELGNGELLAEELLIVQEYLNSITGEFSSDDLLGEIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_RHILO
Sequence: MNGQNIRIRLKAFDHRVLDASTKEIVSTAKRTGANVRGPIPLPTRIEKFTVNRSPHVDKKSREQFEMRTHKRLLDIVDPTPQTVDALMKLDLAAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: GLTL_ECO57
Sequence: MITLKNVSKWYGHFQVLTDCSTEVKKGEVVVVCGPSGSGKSTLIKTVNGLEPVQQGEITVDGIVVNDKKTDLAKLRSRVGMVFQHFELFPHLSIIENLTLAQVKVLKRDKAPAREKALKLLERVGLSAHANKFPAQLSGGQQQRVAIARALCMDPIAMLFDEPTSALDPEMINEVLDVMVELANEGMTMMVVTHEMGFARKVANRVIFMDEGKIVEDSPKDAFFDDPKSDRAKDFLAKILH
What is the function of this protein?
Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Glutamate/aspartate import ATP-binding protein GltL.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COX1_LUMTE
Sequence: MRWFYSTNHKDIGTLYFILGVWAGMVGAGMSLLIRIELSQPGAFLGSDQLYNTIVTAHXFVMIFFLVMPVFIGGFGNWLLPLMLGAPDMAFPRLNNMSFWLLPPSLILLVSSAAVEKGAGTGWTVYPPLASNLAHAGPSVDLAIFSLHLAGASSILGAINFITTVINMRWSGLRLERIPLFVWAVLITVVLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGAISHIVSHYTAKLEPFGALGMIYAMLGIAVLGFIVWAHHMFTVGLDVDTRAYFTAVTMIIAVPTGIKVFSWLATIHGSKIKYETPVLWALGFIFLFTTGGLTGIILSNSSLDIILHDTYYVVAHFHYVLSMGAVFAIFAAFTHWFPLLTGLTLHHRWANAQFFLMFLGVNTTFFPQHFLGLSGMPRRYSDYPDAFMKWNVVSSFGSLLSFVALMLFIFILWEAFASQRSVISSPHMSSALEWSDPILPLDFHNLSETGIITYPK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UL24_PSHV1
Sequence: MPRRRRGPRCDPSSALAVDVAAAVAAATSRTRAQKVRKAKKVLAANGHKWHRRAKTPVNKRTLVAARLLAGVRCHNRFYGALVSSFETAYCMNHRHGSDGLAATIIAEACGAVPVCSLNTTIMFEVNLGGRRPDCICVLDRAGVAGAPRESVCLIVELKTCRFSRSALTESKKNQYATGLRQLRDSAKIICDVAVPGADFVHIVPVLVFVAQRSMRIMDVRKFNERVVRANAELLRLRLAALGVYSRSFAAAPQRLQSAQDRCHDHAATPKPTPAVVPSPPAPPNPAPPQSRVGFGSALAMATAVMLGEYARENKPPR
What is the function of this protein?
May play a role in the dispersal of host nucleolin from the nucleolus throughout the nucleus leading to a decrease in ribosome biogenesis.
What are the official names of this protein?
Protein UL24.
What is the protein family that this protein belongs to?
Belongs to the HHV-1 UL24 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host Golgi apparatus.
Protein: RL10_MACCJ
Sequence: MSTKAIEIKQQKADVITEQLKNSVSTIIVDYRGLTVAQVTELRKQLREAGVEFKVYKNTLVRRSAAAAGIEGIDEFLTGPNAIAFSTEEVVAPAKIIADFAKENEALEIKAGIIEGTVTSAEDVKAIASLPSKEGLISMVLSVLQAPIRNFAYAVKAVGEQQGGEETAAEEA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: PAC11_YEAST
Sequence: MERLKQLEEKRRQLKELRERRKQASLFPGSETMGHHPTEVHAKATMVSVSVQTDMEEGSKIQEPQSAYLRRKEVITYDKGIQTDQIEEEQLQENENHTTTDAVAIETTAADENNKDKAENDQPRLELAKPFLVEEAAATLSNASFARLETEVSASGQQAPSNMQQDKDNLMQWNMVSENLQSETDCDCIAQEYDPGKGVLVVVYLRLPPADLQYASSEAAWSVVNVVKCDNASGRNGLLIDMVEFRGTRIMTATILRRYHPESNVISILLATLTGKIILYELRLKQKKPETPVVYVVQRNMVARHYFQHPVVAVIETSSVQDQERVLVAADNGNIMELSCLDLTVLRKPQQLRPVPLSQLLSLENDTCTYTERLQRLAKFDEVGIACMAYTSEDPQYVWIGGEDGGIYKVFWDQPGPLYLSLDNNGFQPAENHSTRVTGLEFHWDDARRLMLLLSCSTDWTVRLWDARAGKAIIGAPLLLGGPVLRARWLEKNNGGENSRTLRCQVWCADGRLVVVNWAFDAKTSLYTATVIS
What is the function of this protein?
Required for viability in the absence of the kinesin-related CIN8 mitotic motor.  May be a dynein intermediate chain.
What are the official names of this protein?
WD repeat-containing protein PAC11.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HIS3_BRASO
Sequence: MAFLPKFDSAGLVTCVTTDAVSGDVLMVAHMNDEALRKTIATGEAWYFSRSRNALWRKGESSGQTQRVVEMRTDCDQDAVWLRVEQRGAACHTGRHSCFYRKVEMAGEGGARLVFVDADRLFDPAAVYRK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2AJ_CHICK
Sequence: MSGRGKQGGKVRAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHKAKSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.J, H2a/j, Histone H2A-IX.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DXR_BACVZ
Sequence: MKNICLLGATGSIGEQTLDVLRMHQDQFRLVSMTFGKNAEKAIPLIRTFQPKYIAVGDMDTYQKVKEASFSHECQIGIGEEGLIEAAVMDEVDIVVNALLGSVGLIPTLKAIEQKKTIALANKETLVTAGHIVKGHAKRYGVPLLPVDSEHSAIFQALQGEQCKNIERLVITASGGSFRDKTRQELESVTIADALNHPNWSMGAKITIDSATMMNKGLEVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDRSVIAQLGNPDMRVPIQYALTYPDRLPLPETKRLELWEIGSLHFAKADFERFRCLQFAFESGKIGGTMPTVLNAANEEAVAAFLAGRISFLSIEDLIEQALDRHSVIQDPSLADIQEVDKDTRGYVNSILT
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.