PharMolix/UniProtQA huggingface dataset:
Protein: MACB1_AERHH
Sequence: MREPLLQLSGIRRHFGDGERRVEVLKGIDLTIARGEMVAIVGASGSGKSTLLNILGCLDQPSEGSYRVAGRETSRLTADALATLRREHFGFIFQRYHLLGDLSARDNVALPALYAGLAGDARKARAERLLQRLGLGSRLDYKPSQLSGGQQQRVSIARALINGGQVILADEPTGALDSQSGAEVLGILGALHRQGHTLVLVTHDMAIAEQAERIIELKDGAVVADRRREPTPPSPAPTTSRADTGGRGGLAGRLGAAFKMALLAMRAQRMRTFLTMLGIIIGIAAVVSVVALGRGSQQQVLANINAMGTSTLEIFPGSGFGDRRAEAVQTLRVEDAEALAGLGYVHSVTPSLATSVTLRRGSQAVLGSVNGVGEQFFQVRGYRLLQGMLFDAASVTALAQEVVIDENSLARLFGAGESPLGQVILLGSLPCRVIGVVARNQSGFGSDENLNVWIPHTTAMTRMLGQSHLRSISVRVQDEVALAAAEDGISRLLRERHGAQDFFVLNTDSIRQAITSTNATLTLLIAMIALISLVVGGIGVMNIMLVSVSERTREIGVRMAVGARTGDILQQFLIEAVLVCLLGGAAGVLLSLLIGVLFEHFSSQFTLSYSLDAVLMAFFCSSLIGVLFGFFPARRAARMDPIHALERE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS2_FRATO
Sequence: MSLMKEMLSAGVHFGHKKAFWNPQMKEYIFGINHGVHIINLEKTVPLFQDAVNFVGKTVANGGKILFVGTKRQAQDIVEAEAKRCGMPFVSHRWLGGMLTNYKTVRQSIKRLAQLEKMREDGTLESLTKKEMLQNIRTIEKLEKVLGGIKEMGGLPDAIVVIDGNKEHIAIQEAQKLGIKVVAIVDTNSNPEGIDYIIPGNDDAVKSISFYMKKFADAVIDAQGLDRAVEAKADEAAQA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: DSC1_SCHPO
Sequence: MDRRRWVPSTPVVTLLLLFMLFAPAPRLPSRNGESSEKSIKAEKRAFSEIKNATFLNIPERVEHSLTFPTEIWETRDGLFEEPVGKGDSHLNHTSVMTGNWNILPYPSFGKVSPNVTWHTTLRNIVMSQSGRFSANLYEYVDGNSDGISFVLNLENNNDTSVYHMTFHGDRVKPINVFLGSTDVTPNFGGVDVIPWLLKDSPYKDAPPLDGTEYFPLLQNRSLERIETRLQDAQTVGWSPLVFEEEEVTCSAFVFLHNKNTGLDKETLKAIENEFYHPQGVSTQKMPEVFVSGLVYSPDCNVAFTFSNTKGPRNFVLENHLVRFSSLYIFIVLSQIFVLLRQMRINSPSHVQRLSFLTIAMQAGLDAYIAIFFLSTNAVIEKGYLPFVSVAFLSLVPSVMFTMRYLALILRVQNSNMPPPAPRPVTNNSSNNNTNQSNASNENSPNAPSAANDNTETTTVNPPQEDDQPMTQHERDQRDWSAVCLRFYFIILVVCIASLYSAFWPVIYRFYFISALIFTSYSFWIPQIIQNVKQGTSRSFTWTYILGASVLRLYLPLAIFIDSELILGFPPKYFFALGLVLWMLFQVLVLLVQDTLGPRFFLPKKFFLSSPVYDYHPVIQQDDLEAFMRDANVCPICMQPIELVSTGSTLNPASMMVRRNYMLTPCHHLYHRQCLLQWMETRSICPVCRCHLPAV
What is the function of this protein?
Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions.  The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.
What are the official names of this protein?
DSC E3 ubiquitin ligase complex subunit 1, Defective for SREBP cleavage protein 1, RING-type E3 ubiquitin transferase DSC1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: CMOB_PSEFS
Sequence: MIDLSPLARHLVGTPLAVWAQGLQAQLDSKMEKGHGDLDRWQSALDALPNIQPSEVDLLNDLALDTDCDDATRAQMRTALMGLCPWRKGPFHLFGVHVDTEWRSDWKWSRVAPHLDLKGKRILDVGCGNGYYMWRMLGAGADSVIGVDPNWLFFCQFQAVQRYLSEPKAWHLPFPFEDLPANLEGFDTVFSMGVFYHRRSPIEHLLALKDTLVKGGELVLETLVVEGDQQQVLVPEDRYAQMRNVWFLPSVPALMLWLRRAGFSDVRCVDVSVTTVEEQRGTEWMKYQSLSDFLDPEDHSKTLEGLPAPMRAVIIAKK
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: RM02_BOVIN
Sequence: MALRVVTRALGSLSLTPRIAAVPGPSLLPAAQVTNNVLLQLPSASMLLPSRPLLTSVALSAKFVSWKSRTKYTTMPVKMRKSGGRNHTGRIQVHGIGGGHKQRYRMIDFLRFRPEQESKPGPFEEKVIVVRYDPCRSADIALVAGGNRKRWIIATENMKAGDTILNSDHIGRMAVAAREGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLLRKVNGTAIIQLPSKRQMQVLETCTATVGRVSNVDHNKRVIGKAGRNRWLGKRPNSGRWHRKGGWAGRKIRPLPPMKSYVKLPSAAAQN
What are the official names of this protein?
39S ribosomal protein L2, mitochondrial, L2mt, MRP-L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MCM6M_XENLA
Sequence: MELGGPAAAGDTDIAGQQLFKDELSDKCQKLFLEFLEECKGKDGSNLYVSAAEELIRPERNTLAVNFTDIEYYNQQLATTIQEEYYRVYPHLCRAVRSFARQMGNIPANKEFYIAFSDFPARQKIRELSSAKIGTLLRISGQVVRTHPVHPELVSGTFLCMDCQSIVKDVEQQFRYTQPTICKNPVCANRRRFTLDTNKSRFVDFQKVRIQETQAELPRGAIPRSVEIILRAEAVESAMAGDRCDFTGTLIVVPDVSALAAGDARMETGAKVTGGEGFNSEGVQGLKALGVRDLSYRLAFLACYVGATNPRFGGKDLREEDQTAESIKNQMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGVLLMLFGGVPKTTMEGTSLRGDINVCIVGDPSTSKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYERSKSLKHNVNLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHARNEESIERVYSIEDIQRYLLFARQFQPKITKEAEEFIVEQYRRLRQRDGSGVAKSSWRITVRQLESLIRLSESMARMHCSDEVQPKHVKEAFRLLSKSIIRVDTPDVSFDQGEDEKNIEGENNGNLNNGEEAMETNQDEPINEKPSSNAGLKMSFAEYKQISNLLVLYMQKMEETEEECHLTTTDLVNWYLKEMEAEIETETELILKKRLIEKVIHRLIYYDHILIELNKSELKTMDDTKETGEDAAEDRILVVNPNYMLED
What is the function of this protein?
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development.
What are the official names of this protein?
Maternal DNA replication licensing factor mcm6, Maternal minichromosome maintenance protein 6, mMCM6, xMCM6.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
Protein: Y1739_CLOB8
Sequence: MMIIISPAKTLDFSKFNETLPMTKPYFLNEARELVEELKKYDNFSLEKLMKISPKLAKLNTQRFQNWSESLESARQCLVAFKGEVFKGIDVGSYTMEDYFYANDNLRILSGLYGVLKPFDGINLYRLEMATRLGIGGFKNLYDYWGNKLIDNIMKDIERRENKAIVNLASYEYFKAIEDIKTIGDIRVITPIFKEYRDGEYKIITIMAKRARGLMTSFIIRNKIEDLEELKEFNHDGYEFNEELSNEADLVFTRDIHNRN
What are the official names of this protein?
UPF0246 protein Cbei_1739.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: Y1029_AQUAE
Sequence: MQLMDPEKMKKLLEKAKEKGWIADQNVEIKFVILDLKPKWMKCRRTKRLVFQFHMLGDAENKTLCGKTLEEYQILPERQENLVVTQVNMMLGGLGVLVFFDLCPECFGNVNRCEPLKEGEKEKLKEEGLTS
What are the official names of this protein?
Uncharacterized protein aq_1029.
Protein: PROB_THEVB
Sequence: MAQTLVVKIGTSSLAGGKEGNLALATIAQLVEVLCHCQRRGDRVVLVSSGAVGVGAMRLGLTERPQQLAQKQAVAAVGQGHLMRMYDDLFAVLRQPIAQILVTRQNFVDRQSYLNIYNTFQALFELGVIPIVNENDTVAVDELKFGDNDTLSALVASLVEADWLFLLTDVDRLYSADPRIDKTAVPIERVVSLAELAQTIQVGSAGSPWGTGGMATKIRAAEIATEAGVRTVITDGRSPTNLLKILGGEALGTHFEPRPKTINARKRWIARALIPKGELWLDEGAVKAITVGGKSLLAAGITRVEGEFQAQDAVKLCDPTGAEIARGLVNYNSEEIRRVQGQQSTELANILGYAGADTIVHRDNLVVTL
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIFD_RHILT
Sequence: MSLDYENDGDLHARLIDEVLSQYPDKTAKRRKKHLGVAKGREALEQGSDALCETGVKSNIKSIPGVMTVRGCAYAGSKGVVWGPIKDMVHISHGPVGCGHYSWSQRRNYYVGLTGVDAFVTMQFTSDFQEKDIVFGGDKKL
What is the function of this protein?
This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
What are the official names of this protein?
Nitrogenase molybdenum-iron protein alpha chain, Dinitrogenase, Nitrogenase component I.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: RGAP5_ARATH
Sequence: MDIGGPTNIRHVAHVTFDRFDGFLGLPSEFEPDVPRKAPSASATVFGVSTESMQLSYDSRGNCVPVILLLLQSRLYDQGGLQAEGVFRITGENSEEEFVREQLNKGIIPDGIDVHCLAGLIKAWFRELPRGVLDPLPSEQVMQCESDEDFVKVVRLLPQTEASLLNWAINLMADVIQFEHVNKMNSRNLALVFAPNMSQMADPLTALMYAVQVMKLLKSLTEKTVREREASSSVVDRRCSKEAEDGEKEKDNEEEEEDEEEEEEEEDEDEDEEEEGDGVYIIKEEEASEIIKVVADEHKSGSIKSEFEGSSATDSKGDNGVVQPPICSSNP
What is the function of this protein?
Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state.
What are the official names of this protein?
Rho GTPase-activating protein 5, Rho-type GTPase-activating protein 5.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GNTK_MOUSE
Sequence: MEAPGVLLVMGVSGSGKSTVGALLASKLGWKFYDADDYHSEENRIKMAKGVPLSDQDRIPWLCTLHDILLRDVALGQPVVLACSALKKTYRDILIRGGSDAPLKSDDSAKEPLAGGKLLVVYLCGSFDIIYGRLLQRKGHFMPPELLQSQFSILEPPSAPENFIQVSVDKSLPEITAAVMEALK
What are the official names of this protein?
Probable gluconokinase, Gluconate kinase.
What is the protein family that this protein belongs to?
Belongs to the gluconokinase GntK/GntV family.
Protein: RS10_LACGA
Sequence: MASQQIRIRLKSYEHGILDESAAKIVATAERTGAQISGPVPLPTERTLFTVLRSPHKNKDSREQFEIRTHKRLIDILNPTPKTVDSLMKLDLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: Y1289_METJA
Sequence: MNTYLSTLLVLTTIFALSIIAYEWGINIIDTTLNQVSKEKEKNRIEIIKNLINDVIYSGVDSERTFDETKITLKENNVKISNGTKYVSFNITTIEGIDYDVYLEKGTLYIFIYNISAQCPNVYYIKYTNLSIYEFGGNITINYSDNLRHFYVNNSKVYVYSLLMG
What are the official names of this protein?
Uncharacterized protein MJ1289.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: VATE_CITUN
Sequence: MNDADVSKQIQQMVRFIRQEAEEKANEISVSAEEEFNIEKLQLVEAEKKKIRQEYERKEKQVEIRKKIEYSMQLNASRIKVLQAQDDLVSNMMEAASKEVLNVSRDHNSYKKLLKGLIVQSLLRLKEPAVLLRCRKDDHHLVESVLESAKEEYAQKLQVHPPEIIVDHHIYLPPGPGHHNAHGPSCSGGVVVASRDGKIVCENTLDARLDVVFRKKLPEIRKQLVSQVAA
What is the function of this protein?
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit E, V-ATPase subunit E, Vacuolar proton pump subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: Y1040_BACAH
Sequence: MLYLHDVWVNWFEGEENGYNVCHFYEWRKDDTIELLDQVPLLKVDSTLYHYIENELLELPQKLLEDVHHKAYIRKNHERLQQEYCFVVTDGKGIIAIDTIGYNVPIRKSRLIPRQEQMVYEMVENVQAEKYEFQVEEMEKEHHILSPSPFVMNGLTRKERQLKQLLFMALDQLHTTKNTAEIRYWFTEWDPSAYGMVQHMEFEDIWAKLYDEAKTGWSEKHEQLCERLVKGQPFFEKLWEMENEQKVN
What are the official names of this protein?
UPF0736 protein BALH_1040.
What is the protein family that this protein belongs to?
Belongs to the UPF0736 family.
Protein: KPRS_AGRFC
Sequence: MKVFAGNSNRHLAEAICKYLNVPLGNATVKRFADQEIFVEISENVRGEDVFIVQSTSFPANDHLMELLIMIDAMRRSSAKRITAVLPYFGYARQDRKAGPRTPISAKLVANLITEAGADRVLTLDLHAGQIQGFFDIPTDNLFAAPILARDVKDHYDTNNVMVVSPDVGGVVRARALSKRLDCLLAIVDKRRDRPGESEVMNVIGDVSGKDCILIDDIIDSGGTLCNAAEALLKKGATSVTAYITHGVLSGGAVARVASSKLRELVITDSIQPTTGVQSAHNIRVVSTAGLLGEAINRTAQEQSVSGLFD
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUG73_SCHPO
Sequence: MNAKLSSSGMVLKELPEVALQKISSNYYWAVFAVFLLCAIVFPLVSIFSLPQKQTYHRFFSILSLVSCLAYFTMACNYGLKNVFSSASFFREVSVRMVYYVRYIQWLINFPLIIVMLHWTVGVSILEIAYVVCYVLFAIVCLLAAALTSSPYKWAYYGFSFVGYFIALAHSVVLHKKYASRLETSARLGFLWSIVYLHVIWFLYYACWILSEGLNVISPIGEAIFYSILDLFEFGFFGAAFSWMLDLVGIENFKSPQSIPLGACSPADDKFSMCPDMEAQNQADDLAVETRIQISNLPSSPTKNNC
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 73 protein.
What is the protein family that this protein belongs to?
Belongs to the archaeal/bacterial/fungal opsin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNS5_ARATH
Sequence: MSCPIHPRRLFLCLLISLTFFVVDPSSQHIEVKKKQMREKVREMFYHAYDNYMTYAFPHDELKPLTKSFTDSLSELGNLKLEHLPTDYNGSAVTLVESLSSLAILGNSTEFEKGVLWLSENLTFDIDARVNLFECNIRVLGGLISAHLLAIDPNNRLIQGSYNNQLLRLAEDLGKRFLPAFETPTGLPYAWINLKNGVMENETTETSTSGCGSLVLEMGALSRLTGDPRFESAALRALRQLWRMRSSLDLLGTTLDVVTGEWIEYSSSIGAGVDSFYEYLLKAYILFGKEDYWRMFHSAYLASQKYFRHGPWYHEANMWSGKPTYWQLTSLQAFWPGLQVLVGDIAAANSSHREFFHVWEKFGVLPERYLLDHQIIHPTMKYYPLRPELAESTFYLYQATKDPWYLDVGESMVKSLNLYTKVPGGFASVRDVTTMQLEDHQHSFFLAETCKYLYLLFDDSFVAKRNYIFTTEGHPIQVVSSWHEKLPETYFSGNWTLSKSGAWESRASALSLQVCPLISLNSRHPEQQRESACHVLDEQINHKCWSNKECGVDATTCRLRTCSGVGYCGLWNPL
What is the function of this protein?
Can convert Man(9)GlcNAc(2) and Man(8)GlcNAc(2) into N-glycans with a terminal alpha-1,6-linked Man residue in the C-branch.  Functions in the formation of unique N-glycan structures that are specifically recognized by components of the endoplasmic reticulum-associated degradation (ERAD) machinery, which leads to the degradation of misfolded glycoproteins.  Most likely generates N-glycan signal on misfolded glycoproteins that is subsequently recognized by OS9.  Required for ERAD of the heavily glycosylated and misfolded BRI1 variants BRI1-5 and BRI1-9.  Does not seem to play role in N-glycan processing of correctly folded proteins destined for secretion.
What are the official names of this protein?
Alpha-mannosidase I MNS5.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: KITH_VIBPA
Sequence: MAQMYFYYSAMNAGKSTTLLQSSFNYQERGMTPVIFTAALDDRYGVGKVSSRIGLQSDAHLFRPDTNLYQEIAALHEVEKRHCILIDECQFLSKEQVYQLTEVVDKLHIPVLCYGLRTDFLGELFEGSKYLLSWADKLVELKTICHCGRKANMVIRTDEHGVAIKEGDQVAIGGNDRYVSVCRQHYKEALGK
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_CAMJJ
Sequence: MQKQEKIIEMFNQIAPTYDKANRILSFGADVAWRKKACQRVMSLYLKKDLKIADIACGTGDMIEIWQESALKMEKNILNIKGIDPSSGMLNVAKEKFPNVEFIEAGAQNLPLESQSLDILSISYGIRNVVERQKALSEFARVLQKDGILVVLEFTKREKGGFIAACRDFYLKNILPSIGGIISKNKSAYEYLPNSIEGFLSKEEFILELKNAGFEILDYKSFSFGVSSMFIAKKL
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: COX3_ANOGA
Sequence: MSTHANHPFHLVDYSPWPLTGAIGAMTTVSGLVQWFHQYTMTLFILGNVITILTMYQWWRDISREGTFQGLHTFPVTIGLRWGMILFIVSEVFFFISFFWAFFHSSLSPTIELGMTWPPVGIAAFNPFQIPLLNTAILLASGVTVTWAHHALMEGNHSQATQGLFFTIVLGVYFTILQAYEYIEAPFTIADAVYGSTFYMATGFHGLHVLIGTTFLLICFLRHINYHFSKNHHFGFEAAAWYWHFVDVVWLFLYITIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y1094_METJA
Sequence: MDIKYKLASYRICSPEETFEKIQEALKKIETVEIKNIQHLDKVNIPVYYLKRRVVVDGKEGIAIHYGKGANDIQAKVSACMEAIERFSASYDKNKVKEKPDNPINVEDLILPQYADKNVKEWVEGIDIINNETIDVPADAVFYPTSGKLFRGNTNGLASGNNLDEAILHATLEIIERDAWSLADLARKIPTKINPEDAKNPLIHELIEKYEKAGVKIILKDLTSEFEIPVVAAISDDLSKNPLMLCVGVGCHLHPEIAILRALTEVAQSRASQLHGFRRDAKLREEFTSKIPYERLKRIHRKWFEFEGEINIADMPNNARYDLKKDLKFIKDKLSEFGFDKLIYVDLNKVGVDAVRVIIPKMEVYTIDRDRLSRRAFERVKKLYY
What are the official names of this protein?
Uncharacterized protein MJ1094.
Protein: FDHE_YERPB
Sequence: MSIRIVPKDQLGKQREKGTTAGNIPPLLFANLKSLYTRRTERLQQLALDNPLADYLDFAAKITEAQQKALHDHPLVLDMQAELVQSAASGKPPLDGSVFPRTEHWRKLLSALIAELRHDAPDHILAVLDNLDKASVHELELYADALLNRDFSQVGSEKAPFIWAALSLYWAQMASQIPGKARAEYGEHRQFCPVCGSIPVSSVVHIGTHNGLRYLHCNLCESEWHVVRIKCSNCEQTRDLNYWSLDSELAAVKAESCGDCGTYLKILYQEKDPQVEAVADDLASLILDAKMEGEGFARSSINPFLFPGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE homolog.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBP6_LODEL
Sequence: MFGVRYDPEESLLTPTLYHNGRFLPNLKKRKRRVQDHDVVDDDVVVFDNDKDEEEMNKEKKEEEEEEEEEEEETDNSEGESEKSESGSESESESESESESDVDGKHMKEELEDKDDAMEVDTIIEDNEYSGKHKSIFDKFKLSVTRTVNDDVVHSSRDEEEDFQKQSGSREKEKEEVVETQDLAPLPQPQLPRDRKLNSSTQHSANLDWLTTPEYIAIADTKPFSEFPLSPFMHENLESLGFENAFAVQVGVLSKLLPEIQANKLRPDAFGDVLVNASTGSGKTLAYSIPIIESLKDRVVPRVRAIVLVPTKPLINQVRATMLQLALGTNLNIVSLKNDISIREESERLIELVPDVVISTPGRLVEHLAMDSISLSSLRYLVVDEADRLLNQSFQNWSQILISKIHLQQVYDVANVWSLKVQKFIFSATLTTDAGKLASLDFHNPRLLIVNDSQRLVNELFSVPAMLSEYKLNFGVAKSSLKPLILAKFLIAQEKLSDVLVFTKSNESSIRLCTLLQAIFDRICLQEKVKVGFMNLTNNRTSLRSKILKDFTSQKINILVATDLIARGLDVTSIKDVVNYDLLNSSREYVHRVGRTARANQAGNAYNLVFGKGEEKWFKTISSEVSRNNDVKDVEVNLKQLISDEDEKLYQEALQSLQDQVRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP6.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL35_YERE8
Sequence: MPKIKTVRGAAKRFKKTGAGGFKRKHANLRHILTKKATKRKRHLRPKGMVSKNDLGLVVACLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ISPH2_MYCTO
Sequence: MVPTVDMGIPGASVSSRSVADRPNRKRVLLAEPRGYCAGVDRAVETVERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVFSAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGHEGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDETMEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEVLVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2, HMBPP reductase 2.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RNB_HHV2H
Sequence: MASGVSPAHPQTPVGAGSRDLSLKGTPSDGMQPRGADTLEGHSLPTDGPPHRGGDHDPAAGKRGDSGLLRVCAALSIPKPSEAVRPSRIPRAPRVPREPRVPREPREPRVPRSPREPRVPRIPRDPRPPRPPRVPREPRPPREPRATRGLA
What is the function of this protein?
Plays a role in the inhibition of host immune response.  Participates in the inhibition of host autophagy by interacting with and inhibiting host PKR/EIF2AK2.  This interaction also prevents the interferon-induced shut down of protein synthesis following viral infection.  Downmodulates the host RLR signaling pathway via direct interaction with host RIGI and IFIH1.  May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA.
What are the official names of this protein?
Probable RNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the simplex virus US11 protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=Following infection, it is released into the cell cytoplasm.
Protein: STEL1_DROME
Sequence: MSSSQNNNSSWIDWFLGIKGNQFLCRVPTDYVQDTFNQMGLEYFSEILDVILKPVIDSSSGLLYGDEKKWYGMIHARYIRSERGLIAMHRKYLRGDFGSCPNISCDRQNTLPVGLSAVWGKSTVKIHCPRCKSNFHPKSDTQLDGAMFGPSFPDIFFSMLPNLTSPLDDPRT
What is the function of this protein?
Unknown.  In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.
What are the official names of this protein?
Stellate protein CG33236/CG33240/CG33244/CG33245.
What is the protein family that this protein belongs to?
Belongs to the casein kinase 2 subunit beta family.