PharMolix/UniProtQA huggingface dataset:
Protein: MYOC_MOUSE
Sequence: MPALHLLFLACLVWGMGARTAQFRKANDRSGRCQYTFTVASPNESSCPREDQAMSAIQDLQRDSSIQHADLESTKARVRSLESLLHQMTLGRVTGTQEAQEGLQGQLGALRRERDQLETQTRDLEAAYNNLLRDKSALEEEKRQLEQENEDLARRLESSSEEVTRLRRGQCPSTQYPSQDMLPGSREVSQWNLDTLAFQELKSELTEVPASQILKENPSGRPRSKEGDKGCGALVWVGEPVTLRTAETIAGKYGVWMRDPKPTHPYTQESTWRIDTVGTEIRQVFEYSQISQFEQGYPSKVHVLPRALESTGAVVYAGSLYFQGAESRTVVRYELDTETVKAEKEIPGAGYHGHFPYAWGGYTDIDLAVDESGLWVIYSTEEAKGAIVLSKLNPANLELERTWETNIRKQSVANAFVICGILYTVSSYSSAHATVNFAYDTKTGTSKTLTIPFTNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLLEM
What is the function of this protein?
Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration.  Promotes substrate adhesion, spreading and formation of focal contacts.  Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.  Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways.  Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling (By similarity).  Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling (PubMed:23629661).  Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling (PubMed:23897819).  Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex (PubMed:22371502).  Involved in positive regulation of mitochondrial depolarization.  Plays a role in neurite outgrowth.  May participate in the obstruction of fluid outflow in the trabecular meshwork (By similarity).
What are the official names of this protein?
Myocilin, Trabecular meshwork-induced glucocorticoid response protein.
What are the subcellular locations of this protein?
Secreted. Golgi apparatus. Cytoplasmic vesicle. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Secreted, extracellular exosome. Mitochondrion. Mitochondrion intermembrane space. Mitochondrion inner membrane. Mitochondrion outer membrane. Rough endoplasmic reticulum. Cell projection. Cell projection, cilium. Note=Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. It is only imported to mitochondria in the trabecular meshwork. Localizes to the Golgi apparatus in Schlemm's canal endothelial cells. Appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism, likely associated with exosome-like vesicles. Localizes in trabecular meshwork extracellular matrix. SUBCELLULAR LOCATION: [Myocilin, C-terminal fragment]: Secreted. SUBCELLULAR LOCATION: [Myocilin, N-terminal fragment]: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum.
Protein: MAVS_MOUSE
Sequence: MTFAEDKTYKYIRDNHSKFCCVDVLEILPYLSCLTASDQDRLRASYRQIGNRDTLWGLFNNLQRRPGWVEVFIRALQICELPGLADQVTRVYQSYLPPGTSLRSLEPLQLPDFPAAVSGPSAFAPGHNIPDHGLRETPSCPKPVQDTQPPESPVENSEQLLQTNSGAVARMSGGSLIPSPNQQALSPQPSREHQEQEPELGGAHAANVASVPIATYGPVSPTVSFQPLPRTALRTNLLSGVTVSALSADTSLSSSSTGSAFAKGAGDQAKAATCFSTTLTNSVTTSSVPSPRLVPVKTMSSKLPLSSKSTAAMTSTVLTNTAPSKLPSNSVYAGTVPSRVPASVAKAPANTIPPERNSKQAKETPEGPATKVTTGGNQTGPNSSIRSLHSGPEMSKPGVLVSQLDEPFSACSVDLAISPSSSLVSEPNHGPEENEYSSFRIQVDESPSADLLGSPEPLATQQPQEEEEHCASSMPWAKWLGATSALLAVFLAVMLYRSRRLAQ
What is the function of this protein?
Adapter required for innate immune defense against viruses (PubMed:24037184).  Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) (PubMed:24037184).  Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity).  Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (By similarity).  May activate the same pathways following detection of extracellular dsRNA by TLR3 (By similarity).  May protect cells from apoptosis (By similarity).  Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325).
What are the official names of this protein?
Mitochondrial antiviral-signaling protein, MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Virus-induced-signaling adapter, VISA.
What are the subcellular locations of this protein?
Mitochondrion outer membrane. Mitochondrion. Peroxisome.
Protein: PYRH_STAAC
Sequence: MAQISKYKRVVLKLSGEALAGEKGFGINPVIIKSVAEQVAEVAKMDCEIAVIVGGGNIWRGKTGSDLGMDRGTADYMGMLATVMNALALQDSLEQLDCDTRVLTSIEMKQVAEPYIRRRAIRHLEKKRVVIFAAGIGNPYFSTDTTAALRAAEVEADVILMGKNNVDGVYSADPKVNKDAVKYEHLTHIQMLQEGLQVMDSTASSFCMDNNIPLTVFSIMEEGNIKRAVMGEKIGTLITK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTP2_PROHU
Sequence: MMTLNLQTMSSNDMLNFGKKPAYTTSNGSMYIGDSLELLESFPDESISLVMTSPPFALQRKKEYGNLEQHEYVDWFLSFAKVVNKKLKPDGSFVVDFGGAYMKGVPARSIYNFRVLIRMIDEVGFFLAEDFYWFNPSKLPSPIEWVNKRKIRVKDAVNTVWWFSKTEWPKSDITKVLAPYSDRMKKLIEDPDKFYTPKTRPSGHDIGKSFSKDNGGSIPPNLLQISNSESNGQYLANCKLMGIKAHPARFPAKLPEFFIRMLTEPDDLVVDIFGGSNTTGLVAERESRKWISFEMKPEYVAASAFRFLDNNISEEKITDIYNRILNGESLDLNSII
What is the function of this protein?
A beta subtype methylase, recognizes the double-stranded sequence 5'-CAGCTG-3', methylates C-4 on both strands, and protects the DNA from cleavage by the PvuII endonuclease.
What are the official names of this protein?
Type II methyltransferase M.PvuII, M.PvuII, Modification methylase PvuII, N-4 cytosine-specific methyltransferase PvuII.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.
Protein: KITH_SHIBS
Sequence: MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRAEHEQQAIHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAGRPYNEGEQVVIGGNERYVSVCRKHYKEALQVGSLTAIQERHRHD
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TVB29_HUMAN
Sequence: MLSLLLLLLGLGSVFSAVISQKPSRDICQRGTSLTIQCQVDSQVTMMFWYRQQPGQSLTLIATANQGSEATYESGFVIDKFPISRPNLTFSTLTVSNMSPEDSSIYLCSVE
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 29-1.
What are the subcellular locations of this protein?
Cell membrane.
Protein: MOT2_MERUN
Sequence: MPAPTAVPPPHPLPPDGGWGWVVVGASFISIGFSYAFPKSVTVFFKDIQEIFRAGHSKVAWISSIMLAVMYAGGPISSVLVNKYGSRPVVVIGGLLCCTGMILASFSTSMIQLYLTIGFISGLGLAFNLQPALTILGKYFYRRRPLASGLAMTGSPVFLSSLAPFNQYLFNSYGLKGSFLILGGIFLHSCVAGSLMRPVGTSQQSPKSKSKVSSRHDSSTKKAPKLTLAQRINMFLDFSLFKHRGFLIYLSGNVIMFLGFFAPVIFLSPYAKNRGVDDYKAAYLLSVMAFVDMFSRPCGGLIANTRLVRPRIQYFFSLAIVFTGVCHLLCPLAESYTALVVYAIFFGYGFGSVSSILFETLMDLVGPARFSSAVGLVTIVECCPVLLGPPLAGKLVDETGEHKYLFVASGAIVVLAGIWLFIGNAINYRLLAKERKREKARKKKSPNRHSKELESLSKSNQDDVAVRVPQAHRSPSDKERESNI
What is the function of this protein?
Proton-coupled monocarboxylate symporter.  Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate.  Dimerization is functionally required and both subunits work cooperatively in transporting substrate.
What are the official names of this protein?
Monocarboxylate transporter 2, MCT 2, Solute carrier family 16 member 7.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYDND_FRATF
Sequence: MRTHYSSDINEKLQGQKVTVCGWVHRRRDHGGVIFLDIRDRTGLVQLVFNPDNDNFKVADSLRSEFVIKAEGVVNLRPEGQENKNISSGKVEIIGDSIEVINKSKTIPFQLDDFQSTGEDVKLKYRYIDLRRPEMQHKLITRSKAIRYVRNFLDNNGFLDIETPFLTKATPEGARDYLVPSRNFNGKFYALPQSPQLFKQLLMVSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIEASFIDEAFIMSTMERMIAGLFKETIGVEFATPFQVMTFADAIDKYGSDKPDLRIPLEFVNIKEDMQNEEFKVFSGPANDPQSRVIALRISGGNDKLTRKMIDEYTKFVGIYGAKGLAYIKINSLSQGKEGLQSPIVKNISEETLFKVIEKTSAKEDDLLFFGAGKTKIVNDSMGALRAKIGEDLDLFNKDWAPLWVVDFPMFEKDDNRLYAMHHPFTAPKVSSVEDLVNTNPEELSSRAYDMVINGYEVGGGSIRIHKQDIQAKVFNLLGISDDEAREKFGFMLDALSYGTPIHGGIAFGVDRLIMLLTGTTNIRDVIAFPKTQTASCLMTEAPSTVSLEQLNELGIAVKKEER
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPO_HUMAN
Sequence: MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
What is the function of this protein?
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass.  Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
What are the official names of this protein?
Erythropoietin.
What is the protein family that this protein belongs to?
Belongs to the EPO/TPO family.
What are the subcellular locations of this protein?
Secreted.
Protein: HBA_CROCR
Sequence: VLSSADKANIKATWDKIGGHGGEYGAEALERTFLCFPTTKTYFPHFDLSHGSAQVKAHGKKVADALALAAAHLDDLPSALSALSDLHAYKLRVDPVNFKLLSHCLLVTLAAHHPAEFTPAVHSDLDKFLSSVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: TPS4A_MAIZE
Sequence: MASHPAHRSSKAADEELPKASSTFHPSLWGSFFLTYQPPTAPQRANMKERAEVLRERVRKVLKGSTTDQLPETVNLILTLQRLGLGYYYENEIDKLLHQIYSNSDYNVKDLNLVSQRFYLLRKNGYDVPSDVFLSFKTEEGGFACAAADTRSLLSLYNAAYLRKHGEEVLDEAISSTRLRLQDLLGRLLPESPFAKEVSSSLRTPLFRRVGILEARNYIPIYETEATRNEAVLELAKLNFNLQQLDFCEELKHCSAWWNEMIAKSKLTFVRDRIVEEYFWMNGACYDPPYSLSRIILTKITGLITIIDDMFDTHGTTEDCMKFAEAFGRWDESAIHLLPEYMKDFYILMLETFQSFEDALGPEKSYRVLYLKQAMERLVELYSKEIKWRDDDYVPTMSEHLQVSAETIATIALTCSAYAGMGDMSIRKETFEWALSFPQFIRTFGSFVRLSNDVVSTKREQTKDHSPSTVHCYMKEHGTTMDDACEKIKELIEDSWKDMLEQSLALKGLPKVVPQLVFDFSRTTDNMYRDRDALTSSEALKEMIQLLFVEPIPE
What is the function of this protein?
Sesquiterpene synthase involved in the production after herbivore attack of a blend of volatiles that attracts natural enemies of herbivores.  Converts farnesyl diphosphate to (S)-beta-bisabolene and 7-epi-sesquithujene, along with a mixture of more than 20 other minor sesquiterpene olefins.  Can also act in vitro as a monoterpene synthase, converting geranyl diphosphate to (S)-(-)-limonene, beta-myrcene and 11 other monoterpenes.
What are the official names of this protein?
7-epi-sesquithujene synthase, (E)-alpha-bergamotene synthase, Beta-bisabolene synthase, Beta-curcumene synthase, Beta-farnesene synthase, Gamma-curcumene synthase, Sesquisabinene A synthase, Terpene synthase 4, tps4-B73.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERPA_SHEDO
Sequence: MTEQTDAAMPIKFTDAAAIKVKGLLEEEQNPELKLRVYVTGGGCSGFQYGFTFDEKSSADDFVIEKQGVKLVVDPMSLQYLVGGEVDYTSGLEGSRFFVKNPNASSTCGCGASFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: DOT1_ASPFU
Sequence: MGFFDHLQKGGAFSLQAQKPQIRKVVQTRPPPPSRSSSHTPVRSLSQTSPPGRVKRPRDSTSRSVSRDPDHRPSKRLSTPLRNRKRPTPEQRFSSDDDASDTDTSFELRKRARTEDSAEPDLARRIRSLKAFSEENVKPLPLVHAADITSKQKAGNFRRAFGGADRPTEILLQYPSASLKERFNLVVPRDNDDFKPIDDIVHVIDIVSENYIPESEADFFNNESTGIKRRLRRALAHSSETEFREAVASYNREIERLRRSGAIAKHLDATHRLNLPLVERILTQIYARTVSPRVESLRRYENGTDNVYGELLPRFISTIFKETRLKSGHVFVDLGSGVGNVVLQAALEIGCESWGCEMMANACDLAELQQTEFRARCRLWGIAPGKTNLVRGDFLQEQSIIDVLKRADVVLINNQAFTPQLNNEIINHFLDMKEGCQIVSLKSFVPAGHKIQSRNLYSPINLLKVKQLNYWSNSVSWTDVGGTYFIATKDSSRLKAFADSME
What is the function of this protein?
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3.  This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks.  Nucleosomes are preferred as substrate compared to free histone.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone H3-K79 methyltransferase, H3-K79-HMTase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIPA_SHIF8
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVATEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1558_HAEIN
Sequence: MKYYRRALYDKFVHFYLVISDDGSSEAQLRGKMGGLVRKARKKISPDWPKEEQIHQLLQLFYGDWGFHCDPEDYFYARNLYLPYVFEHRQGMPVTLGAMVFYLAEALDLPIYPVNFPTQLILRAEVRDEVAFIDPWDGTYISQEKLQQLYEGAFGFGAKIQPEELDRADLSLLYSRFEQLAKNALIREEHNDMAYHYIKNLMITDAENPYHIRDRGLVLAQMGAYPSALKDLEFFVEHCPKDPTAAFIRTQLLELKGEINKDTFPLH
What are the official names of this protein?
UPF0162 protein HI_1558.
What is the protein family that this protein belongs to?
Belongs to the UPF0162 family.
Protein: YIDD_RUEPO
Sequence: MTPLAHILALPVRAYRLIFSPWVGFNCRYQPTCSAYALEALEKHGALRGSWLAARRIGRCHPLGSDGYDPVPEPKDRKPPHSPAG
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MTND_MACMU
Sequence: MVQAWYMDDAPGDPRQPHRPDPDRPVGLEQLRRLGVLYWKLDADKYENDPELEKIRRERNYSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDKWIRIFMEKGDMITLPAGIYHRFTVDEKNYAKAMRLFVGEPVWTAYNRPADHFEARGQYMKFLAQTA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.  Also down-regulates cell migration mediated by MMP14.
What are the official names of this protein?
Acireductone dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD, Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1, MTCBP-1.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
Protein: AGN2_SCHPO
Sequence: MASLTTALPNKAVVAHFMMGLTYNYAQSDFQNDIQNAISLGLDGFVLNFGNDSWMMSKLTLMYNAADALNLQFLLYLNLDMSEMSTVPASTLVTYVQTFANRGHQARINNNVVVGTFLGQDINFGQSSVNQGWQVAFKNALASAGINIFFMPTWPLDASTIYQTYPVADGFCKWNCWPYYTSSPTSDAEDLVYIQNSKATNKKYMATVSPIFYTHFTSKNYSFFSEGLWFTRWMQLIKDQPNYVQVLTWNDYGESTYIGPTNYAADFPVIGSNSHEWVDSFTHAPLSYSLPLFIQMYKQNTTGLPSNFSGISQLYVTYRVHSKNATASSDSIPRPDNYQNSSDVISVISFAKSSYTLRVSVNGTVLGTTNVNAGVQSANVSFIVNNTAAAGLPLFQILNGTTVIAQGYGPLNILGNNSVVLYNFNFCTTRISW
What is the function of this protein?
Promotes the release of ascospores from asci by hydrolyzing 1,3-alpha-glucan in the ascus wall.
What are the official names of this protein?
Ascus wall endo-1,3-alpha-glucanase, Endo-1,3-alpha-glucanase agn2, Glucan endo-1,3-alpha-glucosidase agn2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 71 family.
Protein: ATG7_YEAST
Sequence: MSSERVLSYAPAFKSFLDTSFFQELSRLKLDVLKLDSTCQPLTVNLDLHNIPKSADQVPLFLTNRSFEKHNNKRTNEVPLQGSIFNFNVLDEFKNLDKQLFLHQRALECWEDGIKDINKCVSFVIISFADLKKYRFYYWLGVPCFQRPSSTVLHVRPEPSLKGLFSKCQKWFDVNYSKWVCILDADDEIVNYDKCIIRKTKVLAIRDTSTMENVPSALTKNFLSVLQYDVPDLIDFKLLIIRQNEGSFALNATFASIDPQSSSSNPDMKVSGWERNVQGKLAPRVVDLSSLLDPLKIADQSVDLNLKLMKWRILPDLNLDIIKNTKVLLLGAGTLGCYVSRALIAWGVRKITFVDNGTVSYSNPVRQALYNFEDCGKPKAELAAASLKRIFPLMDATGVKLSIPMIGHKLVNEEAQHKDFDRLRALIKEHDIIFLLVDSRESRWLPSLLSNIENKTVINAALGFDSYLVMRHGNRDEQSSKQLGCYFCHDVVAPTDSLTDRTLDQMCTVTRPGVAMMASSLAVELMTSLLQTKYSGSETTVLGDIPHQIRGFLHNFSILKLETPAYEHCPACSPKVIEAFTDLGWEFVKKALEHPLYLEEISGLSVIKQEVERLGNDVFEWEDDESDEIA
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity.
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, Cytoplasm to vacuole targeting protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: NIKR_ANASK
Sequence: MLERIGISLEDGLLEQFDKLIAEKGYVNRSEAIRDLIRDALVQRAFTESSGREERVAVVTLVYDHDSSSLAQKLAHIQHENHRAVVSALHVHMDPHNCLEVLVLRGRGKDVVAMGESLVATKGVKYGKLVPATAGHDLG
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: NCAP_I82A4
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWMRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMVKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVLSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVIPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.