PharMolix/UniProtQA huggingface dataset:
Protein: TATA_MAIZE
Sequence: MGIPVVVPVAAAYSCSSSLAAPPRAAAAAARAPSRAHVAAAGMSSRASSFVGGSGGDLAAVAASVAARPRRAGSGGGGALGCKCLFGLGVPELAVIAGVAALVFGPKQLPEIGRSIGKTVKSFQQAAKEFETELKKEPGEGGDQPPPATPTAVSGGEEKGLEASSSKESA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane.  Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation.  TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TATA, chloroplastic, Protein THYLAKOID ASSEMBLY 4, Protein TWIN-ARGININE TRANSLOCATION A.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein. Note=The C-terminus is located in the stroma.
Protein: RS14_ACIAD
Sequence: MAKKGMINRELKREKTVAKYAAKRAELKATIANVNATDEERFDAMLKLQALPRNASPVRLRNRCGLTGRPHGYFRKFGLSRNKLRDTVMQGDVPGVVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: OLIS_CANSA
Sequence: MNHLRAEGPASVLAIGTANPENILLQDEFPDYYFRVTKSEHMTQLKEKFRKICDKSMIRKRNCFLNEEHLKQNPRLVEHEMQTLDARQDMLVVEVPKLGKDACAKAIKEWGQPKSKITHLIFTSASTTDMPGADYHCAKLLGLSPSVKRVMMYQLGCYGGGTVLRIAKDIAENNKGARVLAVCCDIMACLFRGPSESDLELLVGQAIFGDGAAAVIVGAEPDESVGERPIFELVSTGQTILPNSEGTIGGHIREAGLIFDLHKDVPMLISNNIEKCLIEAFTPIGISDWNSIFWITHPGGKAILDKVEEKLHLKSDKFVDSRHVLSEHGNMSSSTVLFVMDELRKRSLEEGKSTTGDGFEWGVLFGFGPGLTVERVVVRSVPIKY
What is the function of this protein?
Involved in the biosynthesis of cannabinoids-related terpenophenolic natural products, which have pharmacological activity (PubMed:18323613, PubMed:19454282, PubMed:19581347, PubMed:22802619).  Polyketide synthase responsible for olivetol biosynthesis, from a C(12)-polyketide, probably 3,5,7-trioxododecanoyl-CoA (PubMed:19454282, Ref. 3).  Catalyzes the first step in the cannabinoids biosynthetic pathway.  The preferred substrate is hexanoyl-CoA, but accepts also CoA esters with C4 to C8 aliphatic side chains (PubMed:19454282).  When using malonyl-CoA and hexanoyl-CoA as substrates, produces undetermined compounds distinct form olivetol or olivetolic acid (PubMed:19581347) that could be hexanoyl triacetic acid lactone (HTAL) (PubMed:18323613) and pentyl diacetic acid lactone (PDAL) (PubMed:22802619).  Produces olivetolic acid when acting in concert with olivetolic acid cyclase (OAC).
What are the official names of this protein?
3,5,7-trioxododecanoyl-CoA synthase, Olivetol synthase, Polyketide synthase-1, Tetraketide synthase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: GATB_ERYLH
Sequence: MSTYRIQGATGEWEVVIGLEVHAQVTSNAKLFSGASTEFGAEPNAQVSLVDAAMPGMLPVPNRECIRQAVRTGMAIEAQINTWSRFDRKNYFYADLPQGYQISQLYHPLVGEGQLLIEADEKAGISEDKVIGIERIHVEQDAGKLMHDQHPTMSYVDLNRCGVALMEIVSRPDMRSPAEAGAYVRKLRAILRYVGSCDGNMEEGSMRADVNVSVRRPGEEFGTRTETKNVNSVRFVMQVIEYEANRQVDLIESGGAVEQETRLFDPGTGTTRTMRSKEDAHDYRYFPDPDLLPLELEDSFLDECRASLPELPDAKRQRYENELGLTPYNARELTAEVETFARFETLLAATAKAIGEDEKKVATQVANWALSVAPGVIKSLGDEAHVENATAERQAAILKMQDAGEISGGQAKEIFEIVLKEGGDPATIADEKGLKQVSDTGAIEAAIDEILANNEDKVEQYKCGKDKLFGFFVGQTMKAMQGKANPAVVNQILKDKLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: DRS3_PHYSA
Sequence: ALWKNMLKGIGKLAGKAALGAVKKLVGAES
What is the function of this protein?
Potent antimicrobial peptide with activity against bacteria and protozoa (By similarity).  Also has activity against fungi (PubMed:8306981).  Probably acts by disturbing membrane functions with its amphipathic structure (Probable).  Binds to healthy erythrocytes (this binding is receptor independent), but has very weak hemolytic activity (PubMed:9395500).  Does not bind to P. falciparum infected erythrocytes, but accumulates within the parasite (PubMed:9395500).  Kills the parasite, but has no hemolytic activity on the host cell (PubMed:9395500).
What are the official names of this protein?
Dermaseptin-S3, DRS-S3, Dermaseptin III, DS III, Dermaseptin-3, DS3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS7_MICLC
Sequence: MPRKGPAPKRPLVVDPVYGSPLVTQLINKVLVDGKKSTAERIVYGALEGARAKNGADPVATLKKAMDNIKPALEVRSRRVGGATYQVPVEVKPGRSTALALRWLVGFSKARREKTMTERLMNEILDASNGLGGAVKRREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: AAR2_RABIT
Sequence: MAAMQMDPELAKCLFFEGATVVILNMPKGTEFGIDYNSWEVGPKFRGVKMIPPGIHFLHYSAVDKANLQELDQFLGPYPYATLKKWISLTSFISEATVERLQPESRQICAFSDVLPVLAMKHTKDRVGQNLPQCGTECKSYQEGLARLPEMKPRAGTEIRFSELPTQMFPAGATPAEITRHSMDLSYALEMVLGRQFPGSPQDVLGELQFAFVCFLLGNVYEAFEHWKRLLNLLCRSEAAMVKHHALYVNLISILYHQLGEIPADFFVDIVSQDNFLTSTLQVFFSSACSTAVDATLRKKAEKFQAHLTKKFRWDFAAEPEDCAPVVVELPEGTSTG
What is the function of this protein?
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.
What are the official names of this protein?
Protein AAR2 homolog, AAR2 splicing factor homolog.
What is the protein family that this protein belongs to?
Belongs to the AAR2 family.
Protein: YPI1_YEAS7
Sequence: MSGNQMAMGSEQQQTVGSRTVSVEEVPAVLQLRATQDPPRSQEAMPTRHNVRWEENVIDNENMNKKKTKICCIFHPQNEDEEECNHHSDDDGSSSSGSSSSESENEKDLDFNERRQRRLERRHRKLEKKRSYSPNAYEIQPDYSEYRRKQQEKKD
What is the function of this protein?
Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.  Regulates the nuclear localization of type 1 phosphatase GLC7 and SDS22, and is involved in the regulation of mRNA 3'-end processing.  May also regulate the activity of type 1 phosphatase PPZ1 (By similarity).
What are the official names of this protein?
Type 1 phosphatases regulator YPI1.
What is the protein family that this protein belongs to?
Belongs to the YPI1 family.
Protein: LIPA_RHOP5
Sequence: MVVVVDTVSDKPIRPRHPEKAARPDALSPKKPDWIRVRAPTSRGYADTRAIVKENGLHTVCEEAGCPNIGECWDRKHATFMIMGDTCTRACAFCNVKTGMPAALDGAEPANVAEATAKLGLAHLVITSVDRDDLADGGAAHIAATIRAVRERCPSTTIEVLTPDFLRKDGALEIVVAAKPDVFNHNLETVPARYLEVRPGARYFHSIRLLQRAKEIDPTLFTKSGIMLGLGEQRSEVLQVMDDLRSADVDFLTIGQYLQPTLKHHAVMSYIPPEEFSSYESLAYAKGFLMVSSSPMTRSSHHAGADFAKLQAARAALPR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXL3_HUMAN
Sequence: MFDSSQYPYNCFNYDADDYPAGSSDEDKRLTRPAYSYIALIAMAIQQSPAGRVTLSGIYDFIMRKFPYYRANQRAWQNSIRHNLSLNSCFVKVPRSEGHEKGKGNYWTFAGGCESLLDLFENGNYRRRRRRRGPKREGPRGPRAGGAQGPSGPSEPPAAQGRLAPDSAGEGAPGREPPASPAPPGKEHPRDLKFSIDYILSSPDPFPGLKPPCLAQEGRYPRLENVGLHFWTM
What is the function of this protein?
Probable transcriptional regulator.
What are the official names of this protein?
Forkhead box protein L3.
What are the subcellular locations of this protein?
Nucleus.
Protein: TPRGL_HUMAN
Sequence: MLQLRDSVDSAGTSPTAVLAAGEEVGAGGGPGGGRPGAGTPLRQTLWPLSIHDPTRRARVKEYFVFRPGSIEQAVEEIRVVVRPVEDGEIQGVWLLTEVDHWNNEKERLVLVTEQSLLICKYDFISLQCQQVVRIALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFINRWNPWSTNVPYATFTEHPMAGADEKTASLCQLESFKALLIQAVKKAQKESPLPGQANGVLILERPLLIETYVGLMSFINNEAKLGYSMTRGKIGF
What is the function of this protein?
Presynaptic protein involved in the synaptic transmission tuning.  Regulates synaptic release probability by decreasing the calcium sensitivity of release.
What are the official names of this protein?
Tumor protein p63-regulated gene 1-like protein, Mossy fiber terminal-associated vertebrate-specific presynaptic protein, Protein FAM79A.
What is the protein family that this protein belongs to?
Belongs to the TPRG1 family.
Protein: AXL1_ARATH
Sequence: MAEPKTKYDRQLRIWGELGQSALETASICLLNCGPTGSEALKNLVIGGIGSITIVDGSKVEIGDLGNNFMVDAKSVGQSRAKTVCGFLQELNDSVKANFVEENPDTLISTDPSFFSQFTLVIATQLVEDSMVKLDRICREANVMLVLARSYGLTGFVRISVKEHTAIETKPDHSLDDLRLNSPWPELKSYVESIDLNVEEPAAHKHIPYVVILVKVAEEWAQHHSGNLPSTREEKNEFKDLVKSKMVSADEENYKEALLAAFKVFAPTGISQEIQDINHDSCAEVGSNSSDFWVMVAALKEFISNEGGGEVPLEGSMPDMISSTEHYINLQKIYHSKAEADFLSMEQRVKSILVKVGQDPSSISKPTIKSFCKNARKLKVCRYRTIEDEFKSPSTTELHKYLADENYSGAIGFYILLRAVDRFAGTYKKFPGQFDGSTDEDASQLKTIALSLLSEMGCDGYELQEELYNEMCRFGAAEIHVVAALIGGITSQEVIKLITKQFVPKRGTFIFNGIDHKSQSLTL
What is the function of this protein?
Regulatory subunit of the dimeric ECR1-AXL1 E1 enzyme.  E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP.  E1 finally transfers RUB1 to the catalytic cysteine of RCE1 (Probable).  May function redundantly with AXR1 in the RUB conjugating pathway (PubMed:17655650).  Seems not to be functionally equivalent to AXR1 in vivo (PubMed:21311953).
What are the official names of this protein?
NEDD8-activating enzyme E1 regulatory subunit AXL, Protein AXR1-LIKE, Protein AXR1-LIKE 1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACTT3_HUMAN
Sequence: MNHCQLPVVIDNGSGMIKAGVAGCREPQFIYPNIIGRAKGQSRAAQGGLELCVGDQAQDWRSSLFISYPVERGLITSWEDMEIMWKHIYDYNLKLKPCDGPVLITEPALNPLANRQQITEMFFEHLGVPAFYMSIQAVLALFAAGFTTGLVLNSGAGVTQSVPIFEGYCLPHGVQQLDLAGLDLTNYLMVLMKNHGIMLLSASDRKIVEDIKESFCYVAMNYEEEMAKKPDCLEKVYQLPDGKVIQLHDQLFSCPEALFSPCHMNLEAPGIDKICFSSIMKCDTGLRNSFFSNIILAGGSTSFPGLDKRLVKDIAKVAPANTAVQVIAPPERKISVWMGGSILASLSAFQDMWITAAEFKEVGPNIVHQRCF
What are the official names of this protein?
Actin-related protein T3, ARP-T3, Actin-related protein M1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Nucleus.
Protein: DNAJ_RICPU
Sequence: MSQNYYQILGVSKTASQADLKKAYLKLAKQYHPDTTDAKDAEKKFKEINAAYDVLKDEQTRAAYDRLGHDAFQNQQSRGGGGNHGGFHPDINDIFGDFFSDFMGGSRRSSRPTSAKVRGSDLKYNLTINLEEAFHGIEKNISFSSTVKCDTCHGSGSEKGETVTTCDACSGVGATRMQQGFFTIEQACHKCQGNGHIIKNPCKKCHGMGRYHKQRNLSVNIPAGVENGTRIRHTGEGEAGIRGGNSGDLYVDITIKPHDIYKVDGANLHCKLPISFVNAALGGEIEVPVIEGGKVNLTIPAGTQNGDQLRLRSKGMSKMRSTIRGDMLTHIHVEVPKNLSKRQRELLEEFKKESINEKENDGSFFNKMKSLWS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A1131_ARTBC
Sequence: MLSLIVACLVLPLICYKLVRSYNQSREDEQFAASKGCQPPRKWSAKWPLGLDMLVKAVRYEKRQQILQLFLEEVAASGSTFEQNLLFARGIDTVEPRNIEAILSTQFTGSGIFTQDGPQWKHSRELLRPQFMTNRFRNFEQIRHAVNNLISSVPDSGVVDLQPLFFRLTFETTLFLLFGHYLPSLKSEGITGHESQFANAFNLGQDYLAQRGRLGDLYWLLGGREFKDACKVCHDFIDNAVQKALKHSSREKKVSDEEKETYVFIDALVQETREPSVLRDQCLNILLAGRDTTACCLTWTLRLLVQHPDVLSKLRDEVRDTIGMGPDAPDPTISQVKKLSYLSLVIKEVLRLYPSVPVNSRAAVKTTTLPTGGGPDGSAPLLVRRGEAVGYCVYAMHRRKDIYGPDADCFRPERWENDALKDVGYGYLPFNGGPRICLGQEFALLEVGYTVVRLLQTFETIEEAETKVPGAPLGEEKQTLTLVVSSGEGCWVSMKKGTK
What is the function of this protein?
Together with an NADPH cytochrome P450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.
What are the official names of this protein?
Cytochrome P450 ARB_01131.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: RNC_PSYA2
Sequence: MKPTSQYPQAVPNPPKNSLSDDTLVISSEFIQRLAVLTRKLGYVFNDLSLAKLALTHRSFDSKKNYERLEFLGDALLGMIVGEALYHRYPTQNEGRLTRMRATLVRQESLVIIAQNLELSNQLILGVGERKGGGRNRASILADAVESLIGAIYLDSQDMNITRECVLSWYGDLIDNVNDQKALKDAKSRLQEWLQSKQFDLPHYELMETRGNAPHQLFVVRCQVNIINCPDITESGESRRIAEQKAAELMINQLHKLPGVPKKRR
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYC_IPPYV
Sequence: MGQIITFFQEVPHIIEEVMNIVLITLSLLAILKGVYNVMTCGLIGLISFLLLCGKSCSLIYKDTYNFSSIELDLSHLNMTLPMSCSRNNSHHYVFFNGSGLEMTFTNDSLLNHKFCNLSDAHKKNLYDHALMGIVTTFHLSIPNFNQYEAMACDFNGGNISIQYNLSHNDRTDAMNHCGTVANGVLDAFYRFHWGRNITYIAQLPNGDGTGRWTFCYATSYKYLVIQNISWADHCQMSRPTPIGFASILSQRIRSIYISRRLMSTFTWSLSDSSGTENPGGYCLTRWMLFAADLKCFGNTAIAKCNLNHDEEFCDMLRLIDFNKQALKTFKSEVNHGLQLITKAINALINDQLIMKNHLRDLMGIPYCNYSKFWYLNDTRTGRVSLPKCWMISNGTYLNETHFSDEIEQEADNMITEMLRKEYQERQGKTPLGLVDLFIFSTSFYSITVFLHLIKIPTHRHIVGQGCPKPHRLNSRAICSCGAYKQPGLPTKWKR
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1.  The glycoprotein spike trimers are connected to the underlying matrix.  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm.  Membrane fusion is mediated by irreversible conformational changes induced by acidification.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: KCY_XANP2
Sequence: MVIAIDGPAASGKGTLARRLAAYYGLPHLDTGLLYRAVGAIVLAQGQLQDEAASVEAARTLDVATLDPEALRTAELGEAASVVAARGGVRAALLDLQHRFAAQPGGAVLDGRDIGTVICPKAQAKLFVTASPEVRAERRHRELIGRGEDVAYETVLADIRKRDERDSARAAAPLVQADDAVLLDTSALDIAQAFAAALAIVEARRAGR
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLCB1_MOUSE
Sequence: MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETSSEAPSETRTTPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHNEIRQQILDEKPKLQTELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPPSLASDAAKVNLKSPSSEEIERENPGREFDTPL
What is the function of this protein?
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:27653213).  Regulates the function of the endothelial barrier (PubMed:27653213).
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, PLC-154, Phosphoinositide phospholipase C-beta-1, Phospholipase C-beta-1, PLC-beta-1.
What are the subcellular locations of this protein?
Nucleus membrane. Cytoplasm. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
Protein: RS14_BACLD
Sequence: MAKKSKIAKEKKRQKLVEQYAELRKELKEKGDYRALSKLPRDSAPARLHNRCEVTGRPRGYMRKFKMSRIAFRELAYKGQIPGVKKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RHAM_YERPB
Sequence: MIRKAFVMAVNPDAHAEYQRRHTPIWPELESVLKAHGAHHYSIFLDETRNLLFGVVEIESEERWNAVAQTAECQRWWQHMADVMPSHPDNSPVSQALREVFYLE
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPIA_ECHGR
Sequence: MGVKCFFDISIGGKPAGRIVFALFDDVPKTVENFRALCTGEKGFGYKGSKFHRIIPGFMCQGGDFTAGNGTGGKSIYGSKFEDENFNHKHSKPMMLSMANAGKNTNGSQFFITTAVTSWLDGKHVVFGEVESGEDVVKDMEAVGSSSGKTSQEVLITDCGQL
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase, PPIase, Cyclophilin, Cyclosporin A-binding protein, EGCyP-1, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXK2_ORYSJ
Sequence: MRKAAAAAVAAAAAVGVALLVRRQLREAKRWGRADAVLRELEERCAAPPGRLRQVADAMAVEMHAGLASEGGSKLKMIISYVDALPSGEEKGVFYALDLGGTNFRVLRVQLGGKEGRVIKQEHDEISIPPHLMTGGSNELFDFIASSLAKFVASEGEDFHLAEGRQRELGFTFSFPVKQTSIASGTLINWTKGFSIDETVGEDVVTELTKALERQGLDMKVTALINDTIGTLAGGRYDDNDVIAAVILGTGTNAAYVERANAIPKWHDLLPKSGDMVINMEWGNFRSSHLPLTEFDQALDAESLNPGEQVYEKLISGMYLGEIVRRVLLKMAEEASLFGDEVPPKLKIPFIIRTPYMSMMHCDRSPDLRTVGAKLKDILGVQNTSLKTRRLVVDVCDIVAKRAAHLAAAGIHGILKKLGRDVPNTDKQRTVIAVDGGLYEHYTIFAECVESTLRDMLGEDVSSTIVIKLAKDGSGIGAALLAAAHSQYREAEEL
What is the function of this protein?
Fructose and glucose phosphorylating enzyme.
What are the official names of this protein?
Hexokinase-2, Hexokinase-3.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
Protein: TBCD5_HUMAN
Sequence: MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI
What is the function of this protein?
May act as a GTPase-activating protein (GAP) for Rab family protein(s).  May act as a GAP for RAB7A.  Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837).  Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity.  Involved in regulation of autophagy (PubMed:22354992).  May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction.  Involved in the trafficking of ATG9A upon activation of autophagy.  May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492).
What are the official names of this protein?
TBC1 domain family member 5.
What are the subcellular locations of this protein?
Endosome membrane. Cytoplasmic vesicle, autophagosome. Note=During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes.