PharMolix/UniProtQA huggingface dataset:
Protein: HISZ_LISW6
Sequence: MNLNKNLPTGTRDKLFREAQAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAKLYRFFDEKGRLTVLRPDMTLPIGRVVSTTGVTLPLKLSYSGKIFRANEDFGGEQNEQTQAGIELVGYPSIKAEIECILSGIGVLNALEIPNFQIELGHAAIYRRVIHLLNLPETAEIDFRLLIQNKSLTGIQQFVANNPSTLDDFILALPRLFGPAKAILKQAKNLTTDKGILTALSEMETIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSFSSPAVGLALNLDSLTTLQNRAGIIKKQAPTILLIHYDLDALPQAEKLMQETPNSELSFFDTSTNAISFAQKWHIPTVVHVSNQGIQTIFQKEADL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF3A_XENLA
Sequence: MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ
What is the function of this protein?
Involved in ribosomal large subunit biogenesis (By similarity).  Acts as both a positive transcription factor for 5S RNA genes and a specific RNA binding protein that complexes with 5S RNA in oocytes to form the 7S ribonucleoprotein storage particle.  May play an essential role in the developmental change in 5S RNA gene expression.  Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III (PubMed:2253880, PubMed:1538401, PubMed:1762917).  Also binds the transcribed 5S RNA's (By similarity).
What are the official names of this protein?
Transcription factor IIIA, TFIIIA, S-TFIIIA/O-TFIIIA.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS5_ECO24
Sequence: MAHIEKQAGELQEKLIAVNRVSKTVKGGRIFSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNMINVALNNGTLQHPVKGVHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVHNVLAKAYGSTNPINVVRATIDGLENMNSPEMVAAKRGKSVEEILGK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: MDTC_SHIFL
Sequence: MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLTPQALFNQGVSLDDVRTAISNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVSSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLEITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE
What are the official names of this protein?
Multidrug resistance protein MdtC, Multidrug transporter MdtC.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPE_XYLF2
Sequence: MSDVLDLACDLISRPSMTPDDAGCQEMIAKRLERAGFICEHLRYAAVSNLWATHGRGAPVLVLLGHTDVVPPGPVEAWTSDPFMPDMRNGILYGRGAADMKGSVAAFVIAAERFLAAYPQHPGTLAILLTSDEEGQAIDGVRKVAETLRQRGQGIDWCLTGEPSSSKRLGDLLRVGRRGSLSATLHVKGVQGHVAYPHQARNPIHLALPAFAALTARHWDDGYESFPSTSLQISNIHAGTGANNVIPGALEVAFNLRYNPHWIAPRLESEIVALLDQHGLDYTLHWHRSGEPFYTPEGKLRRIAREVLERFSGAPPEESTGGGTSDARFIAPLGAQCIEVGPVNASIHQVDEHVCLSDLEALPDLYQLLIERLLAEH
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: IOLG_STRAW
Sequence: MSQLLGVAVLGAGHMGADHIRRLDSVVSGARVAAVADPAKERAEEAVAGLDGVLVHTEVAAALDAPGVEAVLIASPGPAHEEALLAAFARGLPVLCEKPMVPDSAGALRIVEAEARLGRRLAQVGFMRRYDAEYMGLKSLLDSGRLGRPLMLHCTHRNVSSPPGFTSAMLINSSVSHEIDAARWLLGQELTAVTVLRPRPSAHAPEGLLDPQFVLFETAGGALVDVEILVNSGFGYQVRCEAVCEAGSVRIGDAHTMVVTSAGGAYQEVAQDYLVRFADAYDREVREWVDATRRGQVTGPSAWDGYAASVVAEAGVRAQDTGDRMTVELAPRPDLYGQNPISR
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
What are the official names of this protein?
Inositol 2-dehydrogenase, Myo-inositol 2-dehydrogenase, MI 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: PLSX_PSEAE
Sequence: MSAPIIAIDAMGGDFGPHCVVPASIAFLAENSSSQLILVGQPALLEELLSRYPSLDRQRLRVHAASEVIGSDERPSQALRGKPDASMRVALELVRDGRAHACVSAGNTGALMALSRHLLKTLPGIDRPAMVTAVPTEKGHCHLLDLGANVDCSAEHLYQFAVMGAVAAEALGCVSPRVALLNVGTEEIKGNQQVKLAASLLQKAQGLNFSGYIEGDGLYRGEADVVVCDGFVGNILLKASEGLAAMVSARIEQRFRDGLAAKLVGALALPLLRRLRGDIAPARYNGASFLGLQGIVVKSHGSAAEEGFQSALRRAALEVRENLPQRLHGRLEHLLL
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: LPLT_YERP3
Sequence: MSQDVLADKPLLSRSMVAVLCAQFFSAFGDNALLFATLALIKQQLYPDWSQPILQMAFVATYIVLAPFVGQIADGFAKGRVMMVANGLKLAGALVICFGLNPFLGYSLVGVGAAAYSPAKYGILGEITSGEQLVKANGMMEASTIAAILLGSVAGGILADWHLMAALGVCALVYAIAVIANLFIPRLAAARSGASWRPRAMTGSFFTACRLLWQDSETRFSLAGTSLFWGAGVTLRFLLVLWVPVALGIADNATPTLLNAMVAIGIVVGAGAAARFVTLKTVKRCLPAGVLIGVMVTIFSLQNSMPMAYLLLIIIGILGGFFVVPLNALLQERGKHSVGAGNAIAVQNLGENTAMLFMLGLYSLVVKLGAPVVAVGVGFGVVFALAIALLWGWQWRQQRQKTRQPE
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRR_PEDPA
Sequence: MEKEIMDAMAMKRALTRITYEIIERNKGVEDIVLIGIKTRGVFIAKRIAERLKQLENFDIPVGELDIAEYRDDQRNSAEPRSTKANSSLAKLDLKDRKVILIDDVLYTGRTIRAAMDAIMDINRPAQISLAVLVDRGHRELPIRADFVGKNIPTAQNEKINVFVREIDDEDVVLLEN
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: PGRP2_PIG
Sequence: MSPGNWKTTMVVRGILLILYGLLLQPEPGTATLPLLMDSVIQALAELERKSPATEAGHIASMWLLSAQGSGAHNPLPRFLLEGQSLKTAKLAPPSLSPEFQGLIEEVARHGVQDGKEYGVVLAPDGSTVAVEPLLAGLEAGLQGHRVVNLPLDSTATFPDIGATVPDLKATSSAHKDTSADVNSADVGTLSPNVRDTDVDAEVTFLDVRPSSTGVQVTSPDVQVSSPDTKAKSPTTVDSLLMVTLARDLGLHFLQGAQTESNSGLGTEGCWDQLSLPRTFTLLDPEASPLTMAFLNGALDGALLGDYLSKVPEPRPPLSHLLNQYYGAGVAGDPGLRSNFRRQNGAALTLTPNLTQQVWGTLILLQRLEPAHPQLQGMSQEQLAQVATHAAKEFTEAFLGCPAIHPRCRWGAAPYRGSPKPLKLPLGFLYIHHTYVPARPCTDFALCAANMRSMQRFHLDTQGWDDIGYSFVVGSDGYVYEGRGWHWVGAHTRDHNSRGFGVALIGNYTAELPSEAALRAVRDELPHCAVRAGLLQPDYALLGHRQLVRTDCPGDALFNMLRTWPRFNMNVKPRTARRASGRSKRRLPLMIPLATDLQ
What is the function of this protein?
May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments.  Has no direct bacteriolytic activity.
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase, Peptidoglycan recognition protein 2, Peptidoglycan recognition protein long, PGRP-L.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
What are the subcellular locations of this protein?
Secreted. Membrane.
Protein: LNT_VIBVU
Sequence: MKNTLFHRLKRPIAAAFVGALTTLAFAPYQIWLVALITPALLLILIHGQSRRQALWTGYAWGFGQFASGISWVYVSIAGFGGMPLAANLFLMGALIAYLAIYPALFTWSYQRFFAKATLLNLLLAAPALWLIADWLRGWVMTGFPWLWLGYSQIDSPLASFAPIGGVELLTLLLLVGAGAIAYAVIHKRWSMLLIPTVLLSTGYGLSHWDWVTPQPDKTTKVALIQGNVDQNLKWLPSQRWPTIMKYTDLSRENWDADIIIWPEAAIPAFEVELPSYLSNLDSAAKMNQSAIISGIVNQAEDGQFYNSILAVGLTPYGDYSFDLTERYHKHHLLPFGEFVPFEQILRPLAPFFNLPMSSFSRGDFVQPNIVANGHPMAPALCYEIIFNEQVRQNVTDDTDFLLTLSNDAWFGRSIGPLQHMEIARMRALELGKPLIRSTNNGLTAVTDHRGKIIASIPQFETAVLRAELTPTQGQTPYHQLGSWPLYIWVALSLALAWWRKRRTNA
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS21_ELUMP
Sequence: MVFVKVRDAEHLEEALKRFKRECEKNGILKEIKRRETYMPPSVKRKIKSQEAQRRMRRTKRKRF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: Y1827_HYDCU
Sequence: MEHLNSLEHHFLIAMPNLTESWFDKTVIYIVEDNEHGTMGLVINLEHNLTVPELLDHFELTVEAPENYADQPVLMGGPVDLEHGFILHEPQGTWQKSLPLRDNLAMTVSEDFLKAMADGTAPEKIVVCLGFSGWEKGQLNDEIQANNWLTIPYNEALLFDVPNDQKWQVALNTLGISPESLSMDAGHD
What are the official names of this protein?
UPF0301 protein Tcr_1827.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: RL40_TOBAC
Sequence: IIEPSLKALASKFNCDKMICRKCYVRCPRRTPQRTCRVLTWIPQARLPPRATNCRKRKCGHTNHVRPKKKLK
What are the official names of this protein?
60S ribosomal protein L40, CEP52.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL40 family.
Protein: GLMU_POLNA
Sequence: MAIHPLDVVIMAAGKGTRMKSSLPKVLHRLGGRALLAHVLDCAAQLSARQAVVITGHGAMEVEAACARRTGASADLSLKFVRQEPQLGTGHAVQQALPVLPDDGITLVLSGDVPLTQAATLQALLAQCDGQRLALLTLSMADPAGYGRIVRAGTQASAQVRAIVEHKDASEAERAIHEIYSGIMAVPTRLLRRWLARLDNDNVQNEYYLTDIVKFAVADGVAVVAHQITDAAQVAGVNSPVQLAELERVYQQRLATTLMEQGVRLADPARLDVRGQLTCGQDVEIDVNCVFDGRVSLGQGVRIGANCVIANAAIAAGAVIHPFTHIDGEKLGVQVGEGAMVGPFARLRPGANLGAEVHIGNFVEVKNSTLARGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTVIEADVHIGSNCVLVAPVTIGAGATVGGGSTITRDVPAGALSVGRGRQVSIANWARPVKKPGV
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATA_BORPE
Sequence: MNAMTNKTLTTAAGAPVADNNNTMTAGPRGPALLQDVWFLEKLAHFDRERIPERVVHAKGSGAYGTFTVTHDISRYTRARIFAEVGKQTPLFLRFSTVAGERGAADAERDVRGFAIKFYTDEGNWDLVGNNTPVFFIRDPLKFPDFIHTQKRDPKTNLRNATAAWDFWSLNPESLHQVTILMSDRGLPQNYRQQHGFGSHTYSFVNDAGERFYVKFHFKSQQGIACYTDGEAAELVGRDRESAQRDLFQNIEQGQFPRWTLKVQVMPEAEAATYHINPFDLTKVWPHADYPLIEVGVLELNKNPENYFAEVEQAAFTPANVVPGIGFSPDKMLQGRLFSYGDTHRYRLGINHHQIPVNAPRCPFHSFHRDGMGRVDGNGGATLNYEPNSFGEWREAKHAAEPPLALDGQAADRWNHRVDEDYYSQPGALFRLMNDDQKQQLFGNIGRHMAGVPEEIQRRQLEHFRRADPAYAAGVAKALGLK
What is the function of this protein?
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
What are the official names of this protein?
Catalase.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
Protein: CAIC_PROSL
Sequence: MDVIGRQHLRQMWDDLAEVYDKKTALIFESAQGKVRQFSYSELNEEINRAANLFHACGIKKGDHVALHLDNCPEFFFCWFGLAKIGAVMVPINARFMYEESAWIINHCQAHFVVTSDNFSPIYQPMLHDKHSPLTQLFLITENCLPTEQGVVDFLSEKAKHPVTLNHHTPLSVDDTAEILFTSGTTSQPKGVVITHYNLRIAGYYSSWQNALREDDIYLTVMPAFHIDCQCTASLPAYSVGATIVLLEKYSARASWKQILKYQATVTECIPMMMRTSMAQPVSPDEKQHKLREVMSYLNLADKEKDASIERLNVRLLTSHGMTETIVGLIGDRPGDKRRWPSIGRPGFCYQAQIRDKQNQQVPNGVVGEICVKGEAGKTLFKEYYNRPDATEKALEPDGWLHTGDYGYRDDEGFFYFVDRSCNMIKRGGENVSCIEIENIIASHPKIQDVAVIGVPDDIRDEAIKAFVVLVDGETLSEEAFFAFCEQNMAKFKVPSAVEFKQGLPRNCSGKVIKKHLQ
What is the function of this protein?
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.  Also has activity toward crotonobetaine and gamma-butyrobetaine.
What are the official names of this protein?
Crotonobetaine/carnitine--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: RIR1_DICDI
Sequence: MISNSINVTPNKESKMYVVKRDGTKENVSFDKITSRISFLCEMEPKLNSDIVDPIEVAQKVVSGVFPGVKTTELDNLAAETAAYMSTRHPDYGILAARISVSNLHKQTSKSFVETVKKQYEFINPKSNLLAPLVSKELYEIVMKHGERLESVIDYYRDFDYDFFGFKTLERSYLHRINGKIVERPQHMLMRVSIGIHGEDLESAINTYKRLSEKLFTHATPTLFNAGTPSPQMSSCFLVQMKEDSIDGIYDTLKQCALISKSAGGIGIAVHKIRAAQSYIRGTNGTSNGLVPMLRVFNDTARYVDQGGGKRKGAFAVYLEPWHADVFEFIDLKKNTGKEEMRARDLFYALWVSDIFMERVEQNGDWALFCPNEAPGLAETHSEEHRALYLKYEATPDLPRRVIKAQELWFAIMESQVETGTPFILYKDACNAKSNQKNLGTISSSNLCTEIIQYTSPDEIAVCNLASIALPKFVRQKVGSTDPKEKEFDHQFLFEITKLITVNLNVIIDRNYYPVAEAKTSNLRHRPIGIGIQGLADVFIKMRMPFDSVAAAKLNVEIAETIYFAALTASHELAIRDGTYESFKGSPASKGILQFDMWNVTPSSRWNWAELKDNIVNKGGLRNSLLIAPMPTASTSQILGNNECFEPYTSNIYSRRVLAGEFTIVNKQLLEDLMELGIWSPEMKNQIVAARGSIQSIGGIPDDLKELYKTVWEIRQRTLIDMAADRGAFIDQSQSFNVFIAEPTFAKLTSMHFYSWKKGLKTGMYYLRTRPAADAIQFTVDPIVSQTPKPVENNINSTTPLKTPTKTPNSSNRISTSPTNNLTSPIRFNITQQQQQQQQQQQQQNNNEDDLANYDGMTCRREEGCLVCGS
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
What are the official names of this protein?
Ribonucleoside-diphosphate reductase large subunit, Ribonucleotide reductase large subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUSA_XYLFT
Sequence: MIPVINQEKQGISGDFRLSVAPMMNWTDRYCRVFHRVLAPSARLYTEMVHAKAVIYGDRERLLGFASVEQPVALQLGGSEPALLAKAASIAVDWGYSEINLNCGCPSDRVQAGSFGACLMREPALVADCVAAMAAVVSVPVTVKCRLGVNEDDDYGRFAKFVDWVIGASSSRMIVVHARNAWLQGLSPKENREIPPLRYDWVYRLKRECPELAVVLNGGITSVEAGLDHLLMVDGVMLGRAAYQDPYILHQFYCALSNAPVLPRALLLRALRPYVEAWLEQGVTLRHIVRHLLGLFHGQPGGRVFRQVLTQGGQRSDADWSLVEQALSIIEG
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.  Specifically modifies U20 and U20a in tRNAs.
What are the official names of this protein?
tRNA-dihydrouridine(20/20a) synthase, U20-specific dihydrouridine synthase, U20-specific Dus, tRNA-dihydrouridine synthase A.
What is the protein family that this protein belongs to?
Belongs to the Dus family. DusA subfamily.
Protein: NADA_MARN8
Sequence: MTKAQDRILVQEHLAHQAEPKPLSASEKADLEARIKVALKEKDAVLVAHYYTDPDIQRLAEETGGCVADSLEMARFGNQHPASTVVVAGVRFMGETAKILNPEKKVLMPTLEATCSLDVGCPADEFSEFCDQHPDRTVVVYANTSAAVKARADWVVTSSCAQAIVEHLDAKGEKILWAPDKHLGGYVQKTTGADVLLWDGSCIVHEEFKYRGLEDLKALYPDAAILVHPESPDAVVQMADVVGSTSQLIHAVQTLPNEEFIVATDNGIFYKMQQLAPNKTLIEAPTAGNGATCRSCAHCPWMAMNGLENLLHVLEHGDQEVHVDDELREDALRPLRRMLDFTANMNLKAAGNA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGFR2_CHICK
Sequence: MPPRLRPLLLRVSLWVLVGSSSPALLHDRSKENGLQLPRLCKFCDVKATTCSNQDQCKSNCNITSICEKNNEVCAAVWRRNDENVTLETICHDPQKRLYGHMLDDSSSEQCVMKEKKDDGGLMFMCSCTGEECNDVLIFSAIDPHKPEEKDEISKVTIISLVPLLVISVAVIVIFYAYRTHKKRKLNKAWEKNVKPKKHKDCSDVCAIMLDDDHSDISSTCANNINHNTELLPIELDIVVGKGRFAEVYKAKLKQNTSEQYETVAVKIFPYEEYASWKTEKDIFSDVNLKHENILQFLTAEERKTDLGKQYWLITAFHARGNLQEYLTRHIISWEDLWKLGGSLARGIAHLHSDHTPCGRPKTPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPSLSVDDLANSGQVGTARYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNGVGEVKEYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLIECWDHDPEARLTAQCVAERFSEFKHHDKLSGRSCSEEKIPEDGSVTTAK
What is the function of this protein?
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.  Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.  The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2.  Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4.  The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes.  This constitutes the canonical SMAD-dependent TGF-beta signaling cascade.  Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).
What are the official names of this protein?
TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane raft.
Protein: CPP1_NICBE
Sequence: MATTLISKLTLSSAFLGQQFSSRGNSMRSAPAGLFLRGPRCAATDTPYGGNIPQFPRVNVWDPYKRLGISRDASEEEVWSSRNFLLNQYYNHERSAESIEAAFEKILMASFINRKKTKINLKTRLKKKVEESPPWVQNLLSFVELPPPVIILRRLFLFGFMACWSVMNSTEAGPAFQVAISFGACVYFLNDKTKSLGRAALIGFGALVAGWFCGSLLVPMIPPNLLHPTWSLELLTSLFIYVSLFLGCTFLK
What is the function of this protein?
Exhibits holdase chaperone activity involved in the stabilization of POR proteins against photooxidative stress in chloroplasts.  Required for chloroplast development.
What are the official names of this protein?
Protein CHAPERONE-LIKE PROTEIN OF POR1, chloroplastic, NbCPP1.
What is the protein family that this protein belongs to?
Belongs to the chaperone-like protein of POR1 protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast envelope. Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CMOB_YERPG
Sequence: MIEFGDFYRLIAKGPLSPWLDTLPAQLSAWQRESLHGKFKTWFNAVEHLPQLTPTTLDLHSGVRAEMSPPISAGQREGMENMLRALMPWRKGPFSLYGLDIDTEWRSDWKWQRVLPHISPLAGRTILDVGCGSGYHLWRMIGEGAHLAVGIDPMQLFLCQFEAIRKLLGGDQRAHVLPLGIEQLPELAAFDTVFSMGVLYHRRSPLDHLYQLKNQLVTDGELVLETLVVEGDSQQVLVPGDRYAQMRNVYFIPSAPALKAWLEKCGFVDVRIADMAVTTTEEQRRTDWMTSESLAEFLDPHDHSKTVEGYPAPLRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: URED1_METRJ
Sequence: MHGPLAPAPSPERLGAAPARQRSDGRIRLRVGPARPGGGTRILDLAEAGPSRLRFPRGTCALEAVLVNTAGGVACGDSFAIDLALEPGADLVLTTTAAEKIYRSDGPVSRIANTLTLGEGAGLAWLPQETILFDRARVRRRFEADLADGAALIAAEVVAFGRAARGERIVDGLFADSWRIRRGGRLAYADSVLLEGPISDHLARPAIGGGARACATILDVSPGAEARLEEARARLAEAASPGTTAAASAWNGHLAVRALGDAVGPLRGLVARFLAGYRALPMPRVWQS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD 1.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_AYWBP
Sequence: MNNKDLKTKFIFITGGVVSSLGKGITAASIGQILKNRGLKVSIQKLDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFLDENMSKKSNVTAGQIYQSVINKEREGKYLGKTVQVIPHITEEIKQKLTDAALFHKSDVVIVEIGGTVGDIESSPFLEAIRQVRFDFGYRNVLYLHTTLVPYLKKTKEIKTKPTQHSFKELRALGIQPQILVLRSEVPINQETKNKISALCDINSQAIFEALDVDILYQMILNLNHQGIDDFILQHFKLTNFPTADLQAWQQLITRIQNLEKKVVIALVGKYIVLHDAYLSIVEALKHASYQYNCKLEIKWIDAEKVTSDNISSFFEDCDGILVPYGFGNRAIEGKILAINYARTNNIPFFGICLGMQLAVIEYARNVLHLQDANSLEVDEKTPHPVITKKIVDINLGGTLRLGSYSCHLKANTKSKAIYNQEIIYERHRHRFEMNPHYVSLFEKNNDFVVSGINPEQNLCEIVELKSHPWFIAVQFHPEFLSRPLKPHPLFKGFVEASLLN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: YDGA_BACSU
Sequence: MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSLGDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI
What are the official names of this protein?
Uncharacterized protein YdgA.