PharMolix/UniProtQA huggingface dataset:
Protein: MURB_MACCJ
Sequence: MELHTIVDQLKKSIQSEHIKINEPLKKYTYTKTGGNADIYIMPTSYTEVQAALNIARQNDIPVTFLGNGSNIIIRDGGIRGIVISLLNLTKIRVHGHSITASSGAAIIDVSRIARDHHLTGLEFACGIPGSVGGAVFMNAGAYGGEIKDVIDHALVINHEGEIISLDNQALELDYRTSIIQKEHFVVLEASFKLAPGDIQSIQSQMDILTERRESKQPLEYPSCGSVFRRPPGHFAGKLIQDAQLQGHTIGGVQVSEKHAGFIVNVNEGTATDYENMIAHIQETVYKNSGIALETEVRIIGEPL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_TERTT
Sequence: MPTVSMRDMLQAGVHFGHQTRYWNPKMGQYIFGARNKIHIINLEHTVPAFNDALAVIKQMASQKKKVLFVGTKRAAQKTVKEQAERAGMPYVSNRWLGGMLTNYKTIRGSIRSYRDLETQSQDGTFEKLTKKEALMRTRTMDKLELSIGGIKDMGGLPDAMFVIDVEHERIAIQEANKLGIPVIGVVDTNSDPAGVDYVIPGNDDAIRAIKLYVTAMADACLEGAREGSPAAAADEFVEVESEEKVANNG
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: TNKS2_MOUSE
Sequence: MSGRRCAGGGAACASAGAEAVEPSARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLQHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGDYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLHHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRIEVCSLLLSYGADPTLLNCHNKSAIDLAPTAQLKERLSYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDVVEVVVKHEAKVNALDSLGQTSLHRAAHCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGASLGHSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPTCYKPQVLSGVRGPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSAVVSSSAAEGATGLQRKEDSGIDFSITQFIRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNNSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGVFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPIHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIVRPEGMVDG
What is the function of this protein?
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking.  Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation.  Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination.  Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length.  Stimulates 26S proteasome activity.
What are the official names of this protein?
Poly [ADP-ribose] polymerase tankyrase-2, ADP-ribosyltransferase diphtheria toxin-like 6, ARTD6, Protein poly-ADP-ribosyltransferase tankyrase-2, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-2, TANK2.
What is the protein family that this protein belongs to?
Belongs to the ARTD/PARP family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles (By similarity). Also found around the pericentriolar matrix of mitotic centromeres (By similarity). During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1 (By similarity).
Protein: CLPP_WOLWR
Sequence: MTLIPIVVEQTSRGERAYDIYSRLVKERIIFVTGPIEDNMASVIVAQLLFLESENPDKDICMYINSPGGVVTAGLSIYDTMQYINPDVSTLCIGQAASMGSLLLAAGTKGKRYSLPHSRIMIHQPSGGYHGQATDIEIHANEILRVKKKLNQIYEKHTGNSLKKIEGMMERDKFMDPEEARKIGLIDRVIAERTDIEIENIKVKQKVG
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBT_DEIRA
Sequence: MAMDTGRDSSALTDLLGRLQPADAEAMARARERQAQLTKPAGALGDLEELSVRLAGVFGTERPEPRGAAVLVAAGDHGVAAEGVSAYPPEVTPAMVANFLADTPAGPGGAAVSALARTLGAEVYVMDAGVNADLPEHPALTRAARRRGTRNLRREAAMTREETVALMLAGAALADRAMDAGADFIIPGEMGIGNTTPAAALTARLLGVDPADVTGRGTGVDDERLAHKVDVVREALARTAVTDPLDVLAEFGGFEIAAMLGMMLAAAARRRAVILDGFVEGSAALVGVALAPALRDFLFPAGECAERGHAAQLADLGLKPMFNLGLRLGEGTGGVLALPLLRGAAATLREMRTFEEAAVPGGGAA
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RS12_PAEAT
Sequence: MPTINQLVRKGRTPKVSKTKAPALKGSPMRRGVCTRVYTTTPKKPNSALRKVARVRLNGGVEVTAYIPGVGHNLQEHSIVLVRGGRVKDLPGVRYKIVRGALDTQGVKNRKQARSRYGAKMEKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RS4_CLOTE
Sequence: MARYTEANCRLCRREGLKLYLKGDRCYTDKCAFSRRGYAPGQHGQSRKKISNYGLQLREKQKAKRIYGVLEKQFRTYYKRADKARGITGENLLVLLEMRLDNVVYRLGYGDSRKESRQLVTHGHFLVNGKKVNIPSFNVSVNDVITVSEKSRATEKFKTFIENPRTLPNWLEGNLENFEGKVVSQPSREDIDVPVNETLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RUVC_SYNY3
Sequence: MDQTEAAQRWLGIDPGLAIIGWAILDGQPDLSAHLVDYGIIETSKNLSTPERLVEIEQDIHVLLEEFSPQAIAMEMPFFSRQIKAAGGVMQALGVINLVIYREKSIQPVFLHQSSWKCHLGNGKANKAEVAAMVQNFFGLEDLPIDDSVDAIAIALAGLNGVRNDIG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: GLSA_CLOB1
Sequence: MNRLLKTIIENNRKWISEGKVASYIPELSKMDKNLLGISVCTLGGEEYWEGDAEVKFTIQSISKIVTLMLAIIDNGEDYVFSKVGMEPTETAFNSIVNLEAKESHKPINPMINAGAIVVASMVAGKDSDEKFDRILKFTRKISGNNDIDINLNVYESEKETGHRNRALAYFMKSTGALKGNVEEILDVYFKQCSIEITCKDLARIGVMLANDGVSPYTGDRIVPRHVARIVKTIMVTCGMYDASGNFAVHIGIPAKSGVGGGIIACAPRRMGIGVLGTALDEKGNSIAGTKILEELSKQLDLSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: RNPA_SYNP6
Sequence: MALPRCHRLRQRDRFPALYRGGRKLSTPSLLLRWLPQAEIESVNESRFAIVISLKVHKRAVRRNRLRRRLQAALLRLRDRLRPGFDGLLTVKPGLDLDTSTSQFLQELEDLLTRAEIIHGRQ
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: SYD_HISS2
Sequence: MMRSHYCGALNRSHIGQQVILSGWVHKRRDLGGLIFIDMRDREGIVQVCFDPKYQEALTEASALRNEFCIKIEGEVIARPDNQINKNMATGEVEVVAKALSVYNVSDVLPLDFNQNNTEEQRLKYRYLDLRRPEMAQHLKTRAKITAFVRRYMDENGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPEVREIMEKMVHGLWLNTIGVDLGKFPTMTWQEAMERFGSDKPDLRNPLEIVDVADIVKDIDFNVFSDPANSSNGRVAVIRVPNGINITRKQIDEYTQFVGIYGAKGLAWVKINDINAGLEGVQSPIAKFLTTEKIKAIFDRTSAQSDDILFFGADKWQTATDAMGALRLKLGRDLGLTHLDEWKPLWVIDFPMFERDEEGNLAAMHHPFTSPKDFTPEQLEANPTSAVANAYDMVINGYEVGGGSVRIFDPKMQQTVFHILGIDEDQQREKFGFLLDALKFGTPPHAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTDAPSLANEKALEELAIKVTRSE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_RHOPT
Sequence: MPLYEHVFLARQDASAQQVEELTTQITGVIEGLGGKVTKTESWGLRSLTYRMNKNRKAHFVLLNIDGPAAVVSEIERQERINEDVIRYLTVRVDEHEEGPSAMMRKADRDRERDDRGPREGGFRGDREGRGDRDGFRGDRGPRRPREDADAPAAAVEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: MB211_DANRE
Sequence: MIAAQAKLVYHLNKYYNEKCQSRKAAISKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRFEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECYSLNGKQSSAESDAWVLQFAEAENRLLLGGCRKKCLSLLKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDENCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL
What is the function of this protein?
Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity).  It is unclear whether it displays nucleotidyltransferase activity in vivo.  Binds single-stranded RNA (ssRNA) (By similarity).
What are the official names of this protein?
Putative nucleotidyltransferase MAB21L1, Protein mab-21-like 1.
What is the protein family that this protein belongs to?
Belongs to the mab-21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AP1S1_DICDI
Sequence: MIHFLLCFNRQSKVRLSKFYSTYTPTEKNRATREVMNQVLSRSPKFCNFVQWREFTIVYQRFASLFFVMVTDSTDNELVTLESIQRFVVVLDIVFGNICELDLIYEFQRAYQVLDEFLLTGHLQESSSKEILRAINDAEGMEKSLLVAEVLDQHFL
What is the function of this protein?
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes.  The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.  Also involved in early steps of phagocytosis and macropinocytosis.
What are the official names of this protein?
AP-1 complex subunit sigma-1, Adaptor protein complex AP-1 subunit sigma-1A, Adaptor-related protein complex 1 subunit sigma-1A, Clathrin assembly protein complex 1 sigma-1A small chain, Sigma 1a subunit of AP-1 clathrin, Sigma-adaptin 1A, Sigma1A-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle membrane.
Protein: RECF_SHEWM
Sequence: MSLTRLHIETFRNISSAQLHPSDGLNLIYGQNGSGKTSVLEAIYFLGMGRSFRSHLSQRVIQHQDDKLTLFANLSLGEQESKIGLRRFRSGETEVKINGDKIKRLSTLAETLPIQVITPESFSLLFEGPKSRRQFIDWGAFHSDKSFHSAWANVKRILKQRNQLLKNQVSYSQIQFWDKELVRYSELVTLIRKEYVDSLNEQLKGIIVEFLPQVEVKVSFTRGWDSKTDFGQLLETQYLRDVAAGNTGSGPHKADLRLRVGTLPVQDALSRGQLKLLVCALRIAQGKLLKQQTDKNSIYLVDDLPSELDAKHRQLLLQQLMDTGAQIFVTAIDPAAIVDSLTTPPSKMFHVEQGCVTVIDKPTRE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCGF3_HUMAN
Sequence: MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL
What is the function of this protein?
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.  Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).  Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).
What are the official names of this protein?
Polycomb group RING finger protein 3, RING finger protein 3A.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Note=Recruited by the non- coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome.
Protein: RS12_HELAH
Sequence: MPTINQLIRKERKKVVKKTKSPALVECPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTSKFEVISYIPGEGHNLQEHSIVLVRGGRVKDLPGVKYHIVRGALDTAGVNKRTVSRSKYGTKKAKATDNKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: KIWEL_ACTDE
Sequence: MAQLALLLLSLFLTLISLAPPGASISSCNGPCRDLNDCDGQLICIKGKCNDDPQVGTHICRGTTPSPQPGGCKPSGTLTCRGKSYPTYDCSPPVTSSTPAKLTNNDFSEGGDDGGPSECDESYHNNNERIVALSTGWYNGGSRCGKMIRITASNGKSVSAKVVDECDSRHGCDKEHAGQPPCRNNIVDGSNAVWSALGLDKNVGVVDITWSMA
What is the function of this protein?
pH-dependent, voltage-gated and anion-selective pore-forming peptide.
What are the official names of this protein?
Kiwellin.
What is the protein family that this protein belongs to?
Belongs to the kiwellin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVD_PSEA7
Sequence: MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLASHGLDLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVELCQRYYGEGDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGELARGGLLHTDVATVHSPSMADAIARWDITQTRDEAVHTFFKAGPAGIPTQTAFSQNTRWPSLDDDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGRAKIFESQDAAVKGILGDEVKAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVSDEELAARRAEQDRKGWKPAAPRARRVSTALKAYALLATSADKGAVRNKALLDG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: SYE1_METS4
Sequence: MSSVVTRFAPSPTGFLHIGGGRTALFNWLYARKHGGRMLLRIEDTDRERSTEAAIEAILDGLSWLGLDWDGDVIYQFARAARHREVAEGLLAAGRAYRCYASPEELTEMREAARREGRPLRYDGRWRDRNPSEAPPGVRPVIRLRAPVEGETVVEDEVQGRVVWQNKDLDDLVLLRSDGTPTYMLAVVVDDHDMGVTHVIRGDDHLTNAARQTQIYHALGWTVPSMSHIPLIHGPDGAKLSKRHGALGVDAYRGLGYLPAALRNYLVRLGWSHGDQEVFSTEEMVAAFDLKQIGRSPARFDFAKLENLNGQYIRATSDADLVAAIEAILPSQGPARGLPARFDDALRARFLAAMPGLKERAKTLIELLDSAYYLYAPRPLALDERAEGLLGNGGRERLAGVLPRLEALPDWSAASTEQAVRDFAEAAAVKLGHVAQPLRAALTGRATSPGLFDVMAVLGREESLGRLRDQARAA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEPH_ECOLI
Sequence: MARINRISITLCALLFTTLPLTPMAHASKQARESSATTHITKKADKKKSTATTKKTQKTAKKAASKSTTKSKTASSVKKSSITASKNAKTRSKHAVNKTASASFTEKCTKRKGYKSHCVKVKNAASGTLADAHKAKVQKATKVAMNKLMQQIGKPYRWGGSSPRTGFDCSGLVYYAYKDLVKIRIPRTANEMYHLRDAAPIERSELKNGDLVFFRTQGRGTADHVGVYVGNGKFIQSPRTGQEIQITSLSEDYWQRHYVGARRVMTPKTLR
What is the function of this protein?
A murein DD-endopeptidase with specificity for D-Ala-meso-diaminopimelic acid (mDAP) cross-links.  Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion.  Functionally redundant with MepM and MepH.  Partially suppresses an mepS disruption mutant.
What are the official names of this protein?
Murein DD-endopeptidase MepH, Murein hydrolase MepH.
What is the protein family that this protein belongs to?
Belongs to the peptidase C40 family.
Protein: MTND_MICAE
Sequence: MAILRLENGTTYTQLADISLELAKLNVTLNYWPIENEATRQLLKEASLTDEEKEIVLTSLDGYFEQLKQEAGYQARDLIVLHPDIANLDTLLAKFERCHTHADDEVRYIIDGEGVFGFVFPDGSQGELTIQPQEYINVPAHSEHWFHLTASKRVKAVRYFTTTAGWVPEYTETVIRFPSLTAV
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: RN111_PONAB
Sequence: MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKDMNGNQQEQEKSLVVRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSARSHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSSTEGEEDLFVSASENHQNNPAVPSGSIDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQEPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSEQASDTASAVTGSQPSTVSETSATLTSNSTTGTSIGDDSRRTTSSAVMETGPPAMPRLPSCCPQHSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVERPPQVQAPCGANSSSGTSYHEQQALPVDLSNNGIRSHGSGSFHGASAFDPCCPVSSSRAAIFGHQAAAAAPSQPLSSIDGYGSSMVAQPQPQPPPQPSLSSCRHYMPPTYASLTRPLHHQASACPHSHGNPPPQTQPPPQVDYVIPHPVHAFHSQISSHATSHPVAPPPPTHLASTAAPIPQHLPPTHQPISHHIPATAPPAQRLHPHEVMQRMEVRRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAPERSAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIRYISSGLDGTSFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKRKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQLPSES
What is the function of this protein?
E3 ubiquitin-protein ligase (By similarity).  Required for mesoderm patterning during embryonic development (By similarity).  Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP.  Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity).  In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity).  Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL.  Associates with UBE2D2 as an E2 enzyme.  Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates.  Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (By similarity).  Mediates ubiquitination and degradation of sumoylated PML (By similarity).  The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase Arkadia, RING finger protein 111, RING-type E3 ubiquitin transferase Arkadia.
What is the protein family that this protein belongs to?
Belongs to the Arkadia family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, PML body. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol.