PharMolix/UniProtQA huggingface dataset:
Protein: ECOT_ECOHS
Sequence: MKTILPAVLFAAFATTSAWAAESVQPLEKIAPYPQAEKGMKRQVIQLTPQEDESTLKVELLIGQTLEVDCNLHRLGGKLENKTLEGWGYDYYVFDKVSSPVSTMMACPDGKKEKKFVTAYLGDAGMLRYNSKLPIVVYTPDNVDVKYRVWKAEEKIDNAVVR
What is the function of this protein?
General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
What are the official names of this protein?
Ecotin.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
What are the subcellular locations of this protein?
Periplasm.
Protein: COXX_CUPPJ
Sequence: MVTATHSHPVGRVRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWRVLIGGGAGIWLLAGAAFAINCLVEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGMWLLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVIGGLSGAMPPALGWAAVANDVPAEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLNILLYTLVMIAATLLPFVYGMSGYIYLASALVLGAWFLKYSWTMYRNYSDQLAQRAFRFSILYLSLLFAALLIDHYFKFVPQI
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL35_KINRD
Sequence: MPKNKTHSGAKKRFRITGSGKVMREQANKRHLLEVKSSKRTRRLSVDQVVSPADVKKIKKLLGR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ATPB_STRU0
Sequence: MSSGKIAQVVGPVVDVVFANGEKLPEINNALIVYKDSDKKQKIVLEVALELGDGMVRTIAMESTDGLTRGLEVLDTGRAISVPVGKETLGRVFNVLGETIDLDEPFAADAAREPIHKKAPAFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTNKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLTQMGIYPAVDPLASSSRALSPEIVGQEHYEVATEVQRVLQRYRELQDIIAILGMDELSDDEKVLVGRARRIQFFLSQNFNVAEQFTGQPGSYVPVADTVRSFKEILEGKYDHIPEDAFRSVGPIEDVLEKAKSMGY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LPXL_ECOLI
Sequence: MTNLPKFSTALLHPRYWLTWLGIGVLWLVVQLPYPVIYRLGCGLGKLALRFMKRRAKIVHRNLELCFPEMSEQERRKMVVKNFESVGMGLMETGMAWFWPDRRIARWTEVIGMEHIRDVQAQKRGILLVGIHFLTLELGARQFGMQEPGIGVYRPNDNPLIDWLQTWGRLRSNKSMLDRKDLKGMIKALKKGEVVWYAPDHDYGPRSSVFVPLFAVEQAATTTGTWMLARMSGACLVPFVPRRKPDGKGYQLIMLPPECSPPLDDAETTAAWMNKVVEKCIMMAPEQYMWLHRRFKTRPEGVPSRY
What is the function of this protein?
Catalyzes the transfer of laurate from lauroyl-[acyl-carrier-protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).  Has 10 fold selectivity for lauroyl-ACP over myristoyl-ACP.  In vitro, can also catalyze a slow second acylation reaction leading to the formation of Kdo(2)-(dilauroyl)-lipid IV(A).
What are the official names of this protein?
Lipid A biosynthesis lauroyltransferase, Kdo(2)-lipid IV(A) lauroyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LpxL/LpxM/LpxP family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL39_RAT
Sequence: MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL
What is the function of this protein?
RNA-binding component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L39.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_DEIRA
Sequence: MLPRAVAHISAAALDHNLSALAQRSGTRLLLPVKADAYGHGMELVGRLAAAHPDVWGLAVATPQEAETLARLDLGKPLLLLTPPAPEELGALADLGVRLPVSTLAEVEALPAHAQAHLKVDTGMNRLGARPADAVAVGRALAERGQLEGVYTHFATADEPDLSFALTQLVRFRSVLDALPPVLAHCANGGGVLSFGRIEGMSLARPGLAAYGYVPEHLRHVCALRPVMTVRARVNQLHTAYPGETVSYGALWRAERETGVAVVGMGYADGYPRNATGRAAVLIGGERRPVLGRICMDQMMVDVTGLDVGVGDWAELWGEGDLSVTDVARWGDTIEYEVLTGLGSRVERRVG
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: ENDSD_STRDY
Sequence: MDKRLLVKRTLGCVCAATLMGAILATHHDSLISVKAEEKTVQTGKTDQQIGAKLVQEIREGKRGPLYAGYFRTWHDRASTGADGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDIPEGNKALAAAIVKTFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESAPKGNLWFDVNEYDPKNPERGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVGKEYSQRTYQELEAGLKKHPVVDNISHTDYTVSRKLKALMAEDKRYDVIDQKDIPDAALREQVIQQVGQYKGDLERYNKTLVLTVDKIHSLKGLEKLSHLQKLELCQLSNVKEVTPDILPESMKKDAELVMTGMTGLEKLNLRGLNRQTLDGIDVNGLTHLTSFDISHNSLDLSEKSADRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRDTFIGDEEAFAMYKEGAIDGRQYVAKDYTYEAFRKDYQGYKVHLTASNLGESDTSKVTATTDETYLVDVFDGEKIVPHMTLHVGNGATIMENLAKGAKVIGTSGDISLAEKVVDGVVADSFWTWDTKNWIAFDLNSQVIAKEWRLFNGETDPRFKDKELNIQKGRLQILKDKTIHLENMSKDERDSYLADEQNWITVSEITSNQKIYNGSITDITSRYWRFCVDEGVSSKSPQYTELQILGQRLSSDIASTVQD
What is the function of this protein?
Endoglucosidase that acts as a host immune evasion factor by mediating hydrolysis of the N-linked glycan from the Fc region of host immunoglobulin-gamma (IgG) during infection (PubMed:27200457).  Specifically catalyzes the hydrolysis of the beta-1,4 linkage between the first two N-acetylglucosamine residues of the complex-type N-linked glycan located on 'Asn-297' of the Fc region of IgG antibodies (IGHG1, IGHG2, IGHG3 or IGHG4), thereby preventing interaction between IgGs and Fc receptors and ability to activate the complement pathway (By similarity).  Shows a specificity for biantennary complex type N-glycans; does neither cleave larger complex type glycans nor oligomannose and nor hybrid-type glycans (PubMed:27200457).  Specifically acts on IgGs; does not act on immunoglobulin alpha, beta, delta or mu (PubMed:27200457).
What are the official names of this protein?
Endo-beta-N-acetylglucosaminidase EndoSd, Endoglycosidase Sd.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
Protein: 3MGH_GLOVI
Sequence: MRVHHPYHEIPVETLNVDFFNLSPLSVARRLIGCAVVRVLAGERLSGRIVETEAYGGLRDPSCYVVRRDERIWSLLSGPPGVLYLHRAYRHWLLNITCDAVGEPACVLIRALEPTGGEERMRQLRRGARDLTNGPARLVEALAIDSAWEASALPRAEFWLEAGEPVPEEQVLNTVRIGLTRGKDLPWRFAVRDSPWVSRSVEAVLSEASLSAGL
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: RS7_SYNP2
Sequence: MSRRSVTKKRVVPPDAVYNNRLLSMTIRRVMKSGKKSLAARIVYDALDIIKERTGSDPIEVFETAIRNLTPLVEVKARRVGGATYQVPMEVRQGRGTALALRWLIGYARQRSGKSMAIKLANELMDAANETGGAIKKREDTHRMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ATPB_BACAA
Sequence: MNKGRVTQIMGPVVDVKFDGGKLPEIYNALTVKQSNENGTSINLTFEVALHLGDDTVRTVAMSSTDGLVRGTEVEDTGKAISVPVGDATLGRVFNVLGDAIDLDGEVPADVRRDPIHRQAPAFEELSTKVEILETGIKVVDLLAPYIKGGKIGLFGGAGVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLYHEMSDSGVIKKTAMVFGQMNEPPGARQRVALTGLTMAEHFRDEQGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTNKGSITSIQAVYVPADDYTDPAPATTFAHLDATTNLERRLTQMGIYPAVDPLASTSRALSPEIVGEEHYEVARQVQQTLQRYKELQDIIAILGMDELSEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVRGFKEILEGKYDDLPEDAFRLVGGIEEVIENAKKMMA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RR7_PHAVU
Sequence: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQILYRAMKNIQQKTETNPLSVLRQAIRGVTPDIAVKARRVGGSTHQVPVEIGSAQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL22_PARUW
Sequence: MSYAKAISKYIRISPRKARLAAGLIRGLSVSDASLQLTFSGLKGGRLLKKTLDSAVANAETQLDMRRENLKVVEVRVDAGPTLKRAKPKNRGGRHPIMKRTSHFTVIVSNL
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: Y1518_THEAB
Sequence: MKNLIILTGLSGAGKSTALGLLEDMGFYCIDNLPINLVETILPVISMNVDNIAFVLDARSENFERIDEILNNLKKKYASNLKVIFLTAKDAIIINRFAHTRRNHPLLKRVNSLEKAIQLEREILTKALEFSDIVIDTSNLNPHQLREKLVEILGSVKKKFLVRILSFGFKYGLPLDVDFIFDVRFFPNPFYIKDLREKSGRDEKVKEFLYNTQGVKEYIEMIKNVVDFALKRYENEGRMELSIGIGCTGGQHRSVFFAEELASIYRQRYEVLLEHRDVK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein THA_1518.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: YCF12_MICAN
Sequence: MELFAALNLEPIFQLTFVALIMLAGPFVIFLLAFRGGDL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: Y1219_BACC2
Sequence: MGFPKVERLLINYKTLDEFKKFKGCGAQELSMLEELQANIIENDSESPFYGIYYGGSLIARMSLYMKRNGGEPFEITGPYLELYKLEVLPTFQKQGFGQMLVNHAKQMQFPIKTIARIHSSGFWDKLSFNPVSVTDGDFYIWHPETNLNAVTNEESA
What are the official names of this protein?
Uncharacterized N-acetyltransferase BCG9842_B1219.
Protein: FLUDE_STREN
Sequence: MTVHQAPGTPGSVISLRPRYDNWIGGDWKAPAEGRYFANPTPVTGEEYTEIARSTAADIDLALDAAHAAAPAWGRTAPAERAAVLGRIADRIEQHLTELAVAEVWDNGKPIREALAADLPLAVDHFRYFAGVLRAQEGSISQLDEDTVAYHFHEPLGVVGQIIPWNFPLLMAVWKLAPALAAGNAVVLKPAEQTPVSILVLMELIADILPPGVINVVNGFGIEAGKPLAINPRIAKVAFTGETTTGRLIMQYASQNLIPVTLELGGKSPNLFFEDVAAARDDFYDKALEGFTMFALNQGEVCTCPSRALIAGGIYDGFLGDALERTRAVKQGNPLDTETMIGAQASNDQLEKILSYIDIGTAEGAKVLTGGERVDLGGSLSGGYYVAPTIFEGDNRMRIFQEEIFGPVVSVTRFDGYDDAISIANDTLYGLGAGVWTRDLSTAYRAGRAIQAGRVWTNCYHAYPAHAAFGGYKNSGIGRETHKMMLDHYQQTKNLLISYSAKGPGLF
What is the function of this protein?
Catalyzes the oxidation of fluoroacetaldehyde to fluoroacetate.  Has high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.
What are the official names of this protein?
Fluoroacetaldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: FTHS_ENTFA
Sequence: MKTDINIAQAATLKPIQEIAETIGLSEDSLELYGKYKAKIDFPTLQSLEAQPEGKLILVTSINPTPAGEGKSTVTIGLGDALNQINKKTVIALREPSLGPVMGIKGGATGGGYAQVLPMEEINLHFTGDMHAITTANNALAALLDNHLQQGNELKIDSRRVIWKRAVDLNDRALRQVVVGLGGPFQGVPREDGFDITVASEIMAILCLAQNLTDLKERLSRIIVAYNDQREPVTVKDLNVAGALTLLLKDALKPNLVQTIEGTPAFVHGGPFANIAHGCNSILATKTALHLGDYVVTEAGFGGDLGGEKFLDIKVPSLGKAPDAVVIVATIRALKMHGGLAKDQLAEENLPALQKGFANLEKHIQNMQRYDVPVVVAINEFTQDTEKEIQLLKEACQALGVPVELTSVWAQGGAGGTNLAKTVVAEIEADTKQFQPLYNPRQTIEEKIQAIVQTIYGGEQAIFSPKAQKQIADFTKNGWDQLPICMAKTQYSLSDDPQKLGRPEGFTITIRELVPKIGAGFIVALTGDILTMPGLPKVPAALNMDVDETGQASGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: NU2C1_NYMAL
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFNGSFIFPECILIFGLILLLMIDLTSDQKDTPWLYFISSTSLVMSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKRDVRSNEATMKYLLMGGASSSILVYGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALISITVGIGFKLSPAPFHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYIAMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSSALCLLSLGGIPPLAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVVSIYYYLKIIKLLMTGRNKEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 A, chloroplastic, NAD(P)H dehydrogenase, subunit 2 A, NADH-plastoquinone oxidoreductase subunit 2 A.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MCH_METKA
Sequence: MVSVNENALPLVERMIERAELLNVEVQELENGTTVIDCGVEAAGGFEAGLLFSEVCMGGLATVELTEFEHDGLCLPAVQVTTDHPAVSTLAAQKAGWQVQVGDYFAMGSGPARALALKPKETYEEIDYEDDADVAILCLESSELPDEDVAEHVADECGVDPENLYLLVAPTASIVGSVQVSARVVETGLYKLLEVLEYDVTRVKYATGTAPIAPVADDDGEAMGRTNDCILYGGTVYLYVEGDDELPEVVEELPSEASEDYGKPFMKIFEEADYDFYKIDPGVFAPARVVVNDLSTGKTYTAGEINVDVLKESFGL
What is the function of this protein?
Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
What are the official names of this protein?
Methenyltetrahydromethanopterin cyclohydrolase, Methenyl-H4MPT cyclohydrolase.
What is the protein family that this protein belongs to?
Belongs to the MCH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_DICT6
Sequence: MPKPEKVQKVEELYQKMLNANALIFTEFKGLSVADLTQLRGKIRPLNAEYRVVKNTLALLAIRKIYPDKDLEKFFVGPTAITYCYGDPFGVLKALVDYAKEHELLKFKGGIIEGEVYSADEVKELAKLPPKEVLLSQVVGAISAPLSSLVWSLKWPVNKLVWTLDAIAKEKEKISINQ
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: CUER_SALTY
Sequence: MNISDVAKKTGLTSKAIRFYEEKGLVTPPLRSENGYRTYTQKHLNELTLLRQARQVGFNLEECGELVNLFNDPRRHSADVKKRTLEKVAEIERHISELQSMRDQLLALAESCPGDDSADCPIIDNLSGCCHHKAQKPR
What is the function of this protein?
Regulates the transcription of the copA and cuiD (cueO) genes.  Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (PubMed:17768242).
What are the official names of this protein?
HTH-type transcriptional regulator CueR, Copper efflux regulator, Copper export regulator.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_PSEE4
Sequence: MAKQKKHPTGTIAQNKKARHDYFIEHKFEAGLVLSGWEVKSLRAGKAHLTDSYVLLKDGEAWLFGSHITPLTTASTHVIADPIRTRKLLLNKRELERLEAAVAQKGYTCVAMSLYWSKHLIKCEIALGKGKKEFDKRDTVRERDSNRELQRTMRNKGKEE
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: GRPE_EXIS2
Sequence: MEENKQNQNLNTEETTEQQTEAETVEVTEEEVVQADLVEEPAAPDFEAQLAEAKASELRLRADFDNFKRRNRIEAENRAKYSSQTIVEKLLPLVDNLDRALQIESDNEETKSVLAGVEMVKRQLVETLQNEGVIEIPAVGEAFDPNLHQAVVQEPSEEHESGVVTAEFQKGYKLHDRVIRPSMVKVAE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_LEVBA
Sequence: MAEQVTSAQATAKTVRIAARKVRLVIDLIRGKSVAEALAILQFTPRGASPVVAKVLNSAVANAENNFDLDRQDLVVSEAYVNEGPTLKRFRPRAKGSASPINKRTSHITVVVSEKEEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RNH2_LACJO
Sequence: MTITEIKNLLQGEVSKEQLEELKADERKGVQKLLISYEKRQAKYAKALAQFQSRFSYEKEFWQKDQLVAGVDEVGRGPLAGPVVTAAVILPHDFDLIDVNDSKKLSPKKRQALFPKILEKAVSVSVGLANNDVIDQINIYEADRLAMAHAVQGLKVKPDALLVDAMNVPLNIPQVKLIHGDAKSNSIAAASIVAKVFRDNLMDAYGELYPEYDFKHNAGYGTREHMEALEKYGPTPIHRRSFAPVSEYEK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_RHOPB
Sequence: MDKFTTLEGVAAPLKIINVDTDMIIPKQFLKTIKRTGLGKGLFSEQRYKDDGSENPDFILNKPAYRNAKILVAGDNFGCGSSREHAPWALLDFGIRCVISTSFGDIFYNNCFKNGVLPIRVTQADLDKLFDDAERGANATITIDLGKQEIRGPDGGTVKFDIDPFRKHCLMNGLDDIGLTLEKKASIDSYEDKAKTERAWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: SCMC2_BOVIN
Sequence: MLCLCLYVPLIGEAQTEFQYFESKGLPAELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLIGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARKILAREGMAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQRYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASMEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
What is the function of this protein?
Calcium-dependent mitochondrial solute carrier.  Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.  May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity).
What are the official names of this protein?
Calcium-binding mitochondrial carrier protein SCaMC-2, Small calcium-binding mitochondrial carrier protein 2, Solute carrier family 25 member 25.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PDXK_BOMMO
Sequence: MSQDDTPRVLSIQSHVVHGYVGNKSAVFPLQVLGFEVDSINTVQFSTHTAYKHIKGYVLNNDQMKELVEGLVLNEVDYYTHFLTGYSRSPDSLREIAKIIKQLREKNPNLIYVCDPVMGDNGKMYVPEEILPVYRDVLVPLADILTPNQFEAELITGIPMKDLDGALRVIQRLHDMGVKTVVLSSTDLGDEENMIGLASTGGSCYKIPIPKVEATFTGTGDLFAALFLAWSHLTGNDVKLALEKTIATLQSIVVDTYQTARASHLTGKIPPRFTELRLVQNKTVIEDPKIKLKAVKIN
What is the function of this protein?
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:17707212, Ref. 3, PubMed:22079857) (By similarity).  PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (Probable).
What are the official names of this protein?
Pyridoxal kinase, PLK, BmPLK, PL kinase, Pyridoxine kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MURA_HELAH
Sequence: MDFLEIVGQIPLKGGVEISGAKNSALPILAATLLSQQEVTISALPQVADIKAMASLLQNLGAELDWFNSHTLKLCAKSLRHTEATYDLVRKMRASILVLGPLLARFKECLVSLPGGCAIGARPVDLHLKAMQQLGAEITIEQGYIHAKAAKGLKGNDILFDKISVTGTENALMAASLAKGITRIINAAKEPEIAQLCTFLQSGGVEIEGVGSSELKIRGVESDALSLKDIQIIPDRIEAGTYLCVGAITNSQLKINHIIPNHLQAITDKLIEIGFPLDIQQNSIEIYPAKKRQAFEITTKEYPGFPTDMQAQFMALATQCLGTSVIEETLFENRFMHASELQRLGANISLKTNIATIHGSTELTGSDVMATDLRASSALILAALVAKGVSRVHRIYHLDRGYERLEDKINALGAKVLRLKEK
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.