PharMolix/UniProtQA huggingface dataset:
Protein: I17RD_HUMAN
Sequence: MAPWLQLCSVFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGVGPASRNSGLYNITFKYDNCTTYLNPVGKHVIADAQNITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEELKSEGRQCQQLILKDPKQLNSSFKRTGMESQPFLNMKFETDYFVKVVPFPSIKNESNYHPFFFRTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMQVSFDHAPHNFGFRFFYLHYKLKHEGPFKRKTCKQEQTTETTSCLLQNVSPGDYIIELVDDTNTTRKVMHYALKPVHSPWAGPIRAVAITVPLVVISAFATLFTVMCRKKQQENIYSHLDEESSESSTYTAALPRERLRPRPKVFLCYSSKDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWVIQKIHESQFIIVVCSKGMKYFVDKKNYKHKGGGRGSGKGELFLVAVSAIAEKLRQAKQSSSAALSKFIAVYFDYSCEGDVPGILDLSTKYRLMDNLPQLCSHLHSRDHGLQEPGQHTRQGSRRNYFRSKSGRSLYVAICNMHQFIDEEPDWFEKQFVPFHPPPLRYREPVLEKFDSGLVLNDVMCKPGPESDFCLKVEAAVLGATGPADSQHESQHGGLDQDGEARPALDGSAALQPLLHTVKAGSPSDMPRDSGIYDSSVPSSELSLPLMEGLSTDQTETSSLTESVSSSSGLGEEEPPALPSKLLSSGSCKADLGCRSYTDELHAVAPL
What is the function of this protein?
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12958313, PubMed:12807873).  Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK (PubMed:15239952).  Mediates JNK activation and may be involved in apoptosis (By similarity).  May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity).  Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).  Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
What are the official names of this protein?
Interleukin-17 receptor D, IL-17 receptor D, IL-17RD, IL17Rhom, Interleukin-17 receptor-like protein, Sef homolog, hSef.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Protein: NUOD2_KORVE
Sequence: MAHMNPTPVLEAGQDKTMVLNMGPQHPSTHGVLRLLLEIDGETIVRIMPDIGYLHTGIEKTCEAKFYQQVVPMTDRIDYLCPMTNNLAYVLAVEKLLGLEIPERAQWIRVLCNELTRINSHLVWLGTGAMDLGAMTVFLYCFREREELLKLFEAVAGQRMMTSYFRVGGVSLEPPLGWFDRVKKFADTFPSKMDEYEGLLTQNPIFVMRTKGVAKITKEDALALGASGPTLRGSGIDFDLRRDMPYSGYDKFKFNVPVKTEGDVYARYQCRIAELRESCKIVQQALAGMPEGSIKADAPKVVLPDREKMKTQMESLIYHFKIVTEGFTVPPGEVYSAIESPRGEMGYYIVSDGTAKPYRVHMRSPSFANLQMLPSMCTGQLLADVVAAIGSIDIVLGDCDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D 2, NADH dehydrogenase I subunit D 2, NDH-1 subunit D 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HIP_MAIZE
Sequence: MGKPPGARNPAEAEADGDDAVFLELSRELKEEGTRLFNRRDFEGAAFKYDKAVQLLPAGRRVEAAHLRASIAHCYMRMSPAEFHHAIHECNLALEAVPRYSRALLRRAACFEALGRPDLAWGDIRTVLRWEPGNRAARQISDRVRTALEDKGISVALDVLPEDENEIASAKGEERKKSRNKRFDSVAGGREGENGIALLESASTEKQAGPRQTNGTGNHQDHTEDSESNGLEKLEQSTETGEKDMGKKRGAHAAGKKPRCGESKQQKHSAVNHCQDNIGAKEEVMKDVKLVFGEDIRCAQMPANCSLPQLREIVQNKFPSLKAFLIKYKDKEEDLVTITLSEELSWASNLAVSQVPIRFYVVEVNHVQELGVDGVRRRPSFATLERNRDIMLDNGTIGHDVEHKHYADDWMVQFAQIFKNHVGFSSDAYLDLHDLGLRLHYEAMEDTIQREEAQEIFEVAESKFKEMAALALFNCGNVHMSRARRRPCLAEDPLQEFILEKVNVSYDWACTEYAKAGAMFEEAVKTKSDFFEGLIALGQQKFEQAKLSWYYALACKINMETEVLELFNHAEDNMEKGMDMWERMETLRLKGLSKPSKEKVVLEKMVLEGFVKDISADEAFEQASSIRSHINILWGTILYERSVVEFNLGLPSWEESLTVAMEKFKIGGASQADINVIVKNHCANETTQEGLSFKVEEIVQAWSEMHDAKNWRSGPLYFRLQPVFRRRAPKLHHILEHMHYA
What is the function of this protein?
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain.
What are the official names of this protein?
HSP-interacting protein.
Protein: RSMJ_SALNS
Sequence: MQICLMDETGATDGALSVLAARWGLEHDEDNPMALVLTPQHLELRKRDEPKLGGIFVDFVGGAMAHRRKFGGGRGEAVAKAVGIKGDYLPDVVDATAGLGRDAFVLASVGCRVRMLERNPVVAALLDDGLTRGYADADIGGWLQERLQLIHASSLTALTDITPRPQVVYLDPMFPHRQKSALVKKEMRVFQSLVGPDLDADGLLEPARQLATKRVVVKRPDYAPPLADVATPNAIVTKGHRFDIYAGTPLTE
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HK2_MYCTU
Sequence: MALVLAAAGAVTVVQFRDAAHEADPDGALRGLTDDITADLVRELVTILPIVLVIAAVAAYLLSRAALRPVDRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIAWLATTLNTMLTRLQRALAHEQQFVADASHELRTPLALLTTELELRCAGPDPPTS
What is the function of this protein?
Member of the three-protein two-component system HK1/HK2/TcrA.  HK2 transfers its phosphoryl group to TcrA.
What are the official names of this protein?
Sensor histidine kinase component HK2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ERBB2_HUMAN
Sequence: MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
What is the function of this protein?
In the nucleus is involved in transcriptional regulation.  Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription.  Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC.  Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
What are the official names of this protein?
Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Early endosome. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
Protein: PPDPF_XENTR
Sequence: MAAIPSSGSLVATHDYYRRRLGSTSSNSSCGSVDYSGEVIPHHPGLPKSDPGHWWASFFFGKSTHPSMTTVSESPESSGTFSISNGLIPCRLAQESLQKQKVGDPKSDSSPSA
What is the function of this protein?
Probable regulator of exocrine pancreas development.
What are the official names of this protein?
Pancreatic progenitor cell differentiation and proliferation factor, Exocrine differentiation and proliferation factor.
What is the protein family that this protein belongs to?
Belongs to the PPDPF family.
Protein: SECA2_MYCSJ
Sequence: MPKTTTRTPGRLSGKFWKLLGAATEKNQGRSLAQVKASADYETKAADLDDEQLRKAAELLRLEDLSESADIPQFLAIAREAAERSTSLRPFDVQLLGALRMLAGDVVEMATGEGKTLSGAIAAAGYALGGRSVHVITINDYLARRDAEWMGPLIEALGLTVGWITAESTAEERRRAYTCDVTYASVNEIGFDVLRDQLVTDVADLVSPNPDVALIDEADSVLVDEALVPLVLAGTSHRETPRVELIRMVGELTPGRDFDTDTDSRNVHLTDEGARKLEAKLGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLINSSRGRIAQLQRWPDGLQAAVEAKEGIATTETGEVLDTITVQALINRYPTVCGMTGTALAAGEQLRQFYKLGVSPIEPNKPNIREDESDRVYVTAAAKIDAIIEHIEEVHKTGQPVLVGTHDVAESEELHEKLVKRGVPAVVLNAKNDAEEARVIAEAGKLGAVTVSTQMAGRGTDIRLGGSDEGDHDEVAELGGLHVVGTGRHNTQRLDNQLRGRAGRQGDPGSSVFFSSWEDELVQAHLEPNKRPMQADENGRVLTDKAAALLDHAQRVAEGRLLDVHANTWRYNQLTAQQRAIIVERRDALLRTPTAREELAELSPKRYAELAEELSEERLERICRLIMLYHLDRGWCEHLAYLADIRESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETAPSFEDEPGVDLSKLARPTSTWTYMVHDNPLADDTMAALSLPGVFR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 2.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: COXX_LISIN
Sequence: MNQIEKTGELTSSRFTVRDFTELVKIGIVNSNTITAFTGMWLAFQLNGISFIQNVDVIFFTIVGSALIVAASGAFNNVIDRDIDGIMERTKNRPTMTGKISGKRALMVALVLGVVGTIMLFMTTWQAGVLGVIGVFLYVVVYSLYAKRKLVSNTVIGSFSGAVPPLIGWFAVEPSFSIVPIMLFLVMFCWQPPHFYAIAIKRKEEYAAAGIPMLPVVKGIERTKKSMFFWVILLTVLPFFMFDLGLVYVILATLLNIGWLALSIYGFKMDDSIKWAKWMFVYSLNYMTILFVAMVVISIFL
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRMD_PARXL
Sequence: MQFDVVTLFPDMFRALTDWGITSRAAKQERYSLRTWNPRDFTTDNYRTIDDRPYGGGPGMVMLARPLEDAIGAAKAAQAEQGIGAPRVVMMSPQGVTLNHDRVMRFAAEPGLILLCGRYEAIDQRLLDRVVDEEVSLGDFVLSGGELPAMALMDAVVRQLPGVLNDSQSAVQDSFVDVLLDCPHYTRPEEYNGVRVPDVLLGGHHAEIETWRRREALRNTLNKRPDLIVKARKNKMLSRADEAWLASLAKEESKA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTAS_RHIML
Sequence: MRXRWPAQPSKYDRLIAAARAEAPAVTIVAHPCDETSLGGAIEAAEMGLITPILVAPEAKIRNVAAEHRLDLGRREIVDVPHSHAAAAKAVALIREGRGELLMKGSLHTDELMHEVAASATGLRTQRRISHVFVMDVPGHTDTLFITDAAINIFPDLEAKRDIVQNAIDLWVAIGLGEPRVAILSAVETVTAKIPSTIEAAALCKMAERGQITGGVLEGPLAFDNAIDQEAARIKGINSPVAGHAQILVVPDLEAGNMLAKNLTFLTHADAAGLVLGARVPIVLTSRADSVRTRLASCAVAALYAARRRAAQVAAV
What are the official names of this protein?
Phosphate acetyltransferase, Phosphotransacetylase.
What is the protein family that this protein belongs to?
Belongs to the phosphate acetyltransferase and butyryltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_LACAC
Sequence: MAEKEHYVRTKPHVNIGTIGHVDHGKTTLTAAITTVLAEKGLAKAEDYSQIDAAPEEKERGITINTAHVEYETENRHYAHMDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVNYIVVFLNKCDLVDDPELIDLVEMEVRDLLTEYDYPGDDIPVVRGSALKALQGDKEAQDQIMKLMDIVDEYIPTPERQTDKPFLMPVEDVFTITGRGTVASGRIDRGTVKVGDEVEIVGLVDKVLKSVVTGLEMFHKTLDLGEAGDNVGVLLRGVDRDQVVRGQVLAAPGSIQTHKKFKAQVYVLKKDEGGRHTPFFSDYRPQFYFHTTDITGEIELPEGTEMVMPGDNTEFTVTLIKPAAIEKGTKFTIREGGRTVGAGQVTEILD
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_METMP
Sequence: MSGNSSTDLYLFKKSLKELKGKKGKGTELISVYVPAGRRLSDISQYLRQELSQSSNIKSKTTMKNVQSAIEVILQRLKLLKEPLEMGVIIFAGMIPRGGPGTEKMEVYVLEPPEPVKTFVYRCDSLFYTDPLEDFIQDNEVYGVILVDRNEATIGTVRGKTITILKKLTSGVPGKFKAGGQSARRLERLIDDAAHQFMVRIGEYATESFMPILEEKKLKGLLLGGPGNTKNEFAEKDYLHHELKKKIIDTFDLCYTEEFGIRELLDKASDLLRDIDLMKEKNLIQRFFKELIKDDGGLSAYGEAQVMKYLEMGAIDTLIVTEDIGITRVTVKCNNCDITQEVNVKTNEMFKFEEQLKTKACPTCGGAMYIDEEKDIIEYLSDLCNMHNTDLIVVSTDTEEGSQISRAFKGMAAILRYKL
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
What are the official names of this protein?
Peptide chain release factor subunit 1, Translation termination factor aRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCNJ8_MOUSE
Sequence: MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKGTMEKSGLESAVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQQDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVRVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQCPSES
What is the function of this protein?
This potassium channel is controlled by G proteins.  Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.  Can be blocked by external barium (By similarity).
What are the official names of this protein?
ATP-sensitive inward rectifier potassium channel 8, Inward rectifier K(+) channel Kir6.1, Potassium channel, inwardly rectifying subfamily J member 8, uKATP-1.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: COPZ_STAEQ
Sequence: MTQKIIKVEGMSCEHCRNAVESALAKLNGVSSAEVNLDENHVRVEYNDSKVTFENMKEAIEEQGYDVK
What is the function of this protein?
Chaperone that serves for the intracellular sequestration and transport of Cu(+).  Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA) (By similarity).
What are the official names of this protein?
Copper chaperone CopZ.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_ACIB3
Sequence: MKKLWQNCHIATMQNGQYSYIEDAAIVTEGHLIHWIGKQQQLPADTYSETVDLNGAWVTPGFIDCHTHSVFGGNRSVEFEKRLQGVSYAEIAASGGGIASTVRATREASEEQLLNSALKRIRCMQQDGVTTIEIKSGYGLNYENERKMLRVIRQIGEKLPMTVKSTCLAAHALPPEYKDQSDAYIEHICTEMLPKLHAEGLVDAVDAFCEHLAFSPAQVERVFKTAQSLGLPVKLHAEQLSSLGGSSLAARYHALSADHLEYMTEDDVKAMAESGTVAVLLPGAFYLLRETQYPPIESLIKHGVRIALSSDLNPGTSPALSLRLMLNMGSTLFRLTPEQALAGITIHAAQALGLEQTHGSLEQGKVADFVAWDIEHPSEIVYWLGGDLPKRVVQHGQEVIF
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_RHOP2
Sequence: MSAPEPKITPELIASHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSRIHLKGLPTKAPWVLQGPGENAGVIDIGDNQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNSFGVPTVGGQTRFHTRYDGNILVNAMAVGLADSDKIFLAAASGVGMPIVYLGSKTGRDGMGGATMASAEFDEGSEEKRPTVQVGDPFAEKLLLEACLEIMAKDCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDAVPTRETGMTAYEMMLSESQERMLMVLKPEKEKEAEEIFRKWGLDFAIVGYTTPTKRFVVKHGGAVKADLPIKELGDEAPLYDRPHVPSPKLPVIHAREVNAPMPVPEALEKLLATPDLCSKRWVWEQYDHVIGGNTLQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPYEGGKQAVAEAYRNITAVGGKPLAITDNLNFGNPERPEIMGQLVGCLKGISEACIALDSPIVSGNVSLYNETSGRGILPTPSIGGVGLLDDFTKSATLAFKAEGEAILLIGETHGWLGQSVYLRDVCGREEGAPPPVDLACEKRHGDVVRGMIHAGTATAVHDLSDGGLLVALAEMAISGNIGASLDAPPDSTVAHAWWFGEDQGRYLVTVKEDDLLTVLSKLKSVGVPCTQIGTTGGHTLKIDGERAIDVKALRHAHEHWLPDYMAGKN
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLRG1_MOUSE
Sequence: MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPTSKENLKEKGPQNATDSYPHKQYPANQGQDVEYLVTGTHPYPAGPGVALTADTKIQRMPSESAAQSLAVALPSQTRVDANRTGPAGSEYRHPGASDRSQPTAMNSIMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTLDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPLLYTFASGSPDNIKQWKFPDGGFIQNLSGHNAIINTLAVNADGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDRSESRLLTAEADKTIKVYREDETATEETHPVSWKPEIIKRKRF
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome.  Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
What are the official names of this protein?
Pleiotropic regulator 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PRL1/PRL2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: RU1C_YEAST
Sequence: MTRYYCEYCHSYLTHDTLSVRKSHLVGKNHLRITADYYRNKARDIINKHNHKRRHIGKRGRKERENSSQNETLKVTCLSNKEKRHIMHVKKMNQKELAQTSIDTLKLLYDGSPGYSKVFVDANRFDIGDLVKASKLPQRANEKSAHHSFKQTSRSRDETCESNPFPRLNNPKKLEPPKILSQWSNTIPKTSIFYSVDILQTTIKESKKRMHSDGIRKPSSANGYKRRRYGN
What is the function of this protein?
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome.  YHC1/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing.  The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.  Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
What are the official names of this protein?
U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C, U1C.
What is the protein family that this protein belongs to?
Belongs to the U1 small nuclear ribonucleoprotein C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSCL_RHOPS
Sequence: MLKEFREFAMKGNVVDLAVGVIIGAAFGAIVTSMVGDLIMPVIGAVTGGLDFSNYFTPLSKAVTANSLAEAKKQGAVLAWGSFLTITLNFLIVAGVLFGVIRAMNRLKRNDEAVAASPPKPTREQELLTEIRDILKSGIRPQV
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: S29A3_MOUSE
Sequence: MAFASEDNVYHSSNAVYRAPSNHQEADQEALLGKLLDYPAPGLQRPEDRFNGAYIIFFCLGIGGLLPWNFFVTAKEYWAYKLRNCSSPASGEDPEDMDILNYFESYLAVASTVPSLLFLVANFLLVNRVQVHVRVLASLSVSLAIFVVMIVLVKVDTSSWTRGFFSLTIACMAIISSSSTIFNSSVYGLTGSFPMRNAQALISGGAMGGTVSAVALLVDLAASSDVRDSTLAFFLMAAVFLGLCMGLYLLLSQLEYARYYMRPVAPVRVFSGEDNPSQDAPSASSVAPASRVMHTPPLGPILKKTASLGFCAVSLYFVTAFIIPAISTNIQSMHKGTGSPWTSKFFVPLTVFLLFNFADLCGRQVTAWIQVPGPRSKLLPGLVVSRFCLVPLFLLCNYQPRSHLTKVLFQSDIYPVLFTCLLGLSNGYLSTLVLIYGPKIVPRELAEATSVVMLFYMSVGLMLGSACAALLEHFI
What is the function of this protein?
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter).  Mediates transport of adenine, adenosine and uridine (By similarity).
What are the official names of this protein?
Equilibrative nucleoside transporter 3, mENT3, Solute carrier family 29 member 3.
What is the protein family that this protein belongs to?
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note=Intracellular localization shows a partial overlap with late endosomes/lysosomes. Not detected at the cell surface (By similarity).
Protein: LEUC_LEUMM
Sequence: MSKTLFDKIWEKHVITGEIGEAQLIYVDLHLVHEVTSPQPFDGLRSTNRRVRRPDLTFATMDHNVPTKDIFNVQDQMSRLQMDTLVKNTKEFDIPLASIGDDKQGIVHVVGPERGLTQPAKVIVCGDSHTATHGAFGAIAFGIGTSEVEHVLATQTIWQVKPKTMGIKVTGKLPKNTYAKDIIMGIIAKYGVSFGVGYAIEFYGETVENLSMEARMTMCNMSIEAGSRTGMVQPDQTTFDYIEGREQAPKDFESAKNYWSQFYTDDESDFDETLTFDVSNLKPMVTWGTNPGMATPVDQSLPAIKDDNDANAYEYIGLHPNMKPVDINLDYIFIGSCTNSRYEDLEIAANMMKGHHLAPNVTAWVVPGSRAIRNRAIKSGIAQIFEEAGCEWREPGCSACLAMNPDKIPAGKHVASTSNRNFIGRQGAGSRTHLASPAMVAAAGIAGHFVDITTDEFV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RL20_STAA1
Sequence: MPRVKGGTVTRARRKKTIKLAKGYFGSKHTLYKVAKQQVMKSGQYAFRDRRQRKRDFRKLWITRINAAARQHEMSYSRLMNGLKKAGIDINRKMLSEIAISDEKAFAQLVTKAKDALK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.