PharMolix/UniProtQA huggingface dataset:
Protein: CHM1A_PONAB
Sequence: MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARVYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN
What is the function of this protein?
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.  ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.  The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses).  ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.  Involved in cytokinesis.  Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.  May also be involved in chromosome condensation.  Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin.  May play a role in stable cell cycle progression and in PcG gene silencing (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 1a, Chromatin-modifying protein 1a, CHMP1a.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane- associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin (By similarity).
Protein: IBP7_HUMAN
Sequence: MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL
What is the function of this protein?
Binds IGF-I and IGF-II with a relatively low affinity.  Stimulates prostacyclin (PGI2) production.  Stimulates cell adhesion.
What are the official names of this protein?
Insulin-like growth factor-binding protein 7, IBP-7, IGF-binding protein 7, IGFBP-7, IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, Prostacyclin-stimulating factor, Tumor-derived adhesion factor, TAF.
What are the subcellular locations of this protein?
Secreted.
Protein: CASP3_SORBI
Sequence: MKGSSEHGETSKAAPLGRGGVSKGVSVLDLILRFIAIIGTLASAIAMGTTNETLPFFTQFIRFKAQYSDLPTLTFFVVANSIVCAYLILSLPLSIVHIIRSRAKYSRLLLIFLDAAMLALVTAGASAAAAIVYLAHKGNVRANWLAICQQFDSFCERISGSLIGSFGAMVMLILLILLSAIALARR
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 3, SbCASP3.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: HSLU_STAA1
Sequence: MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMIGPTGVGKTEIARRMAKVVGAPFIKVEATKFTELGYVGRDVESMVRDLVDVSVRLVKAQKKSLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGGAIPNFGQNNEDEEEPPTEEIKTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREVAVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQGVQRDILPILEGSVIQTKYGTVNTEHMLFIGAGAFHVSKPSDLIPELQGRFPIRVELDSLSVEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRLAEIAYQVNQDTDNIGARRLHTILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOY_GEOTN
Sequence: MIFKVFYQENADEVPVREKTKTLYIEAESERDVRRKLQDRSINIEYIQPLEGAHLEYEKQSPNFQVLEISS
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: MURB_STRP8
Sequence: MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNHYELSRIVAYANKENMPWLVLGNASNLIVRDGGIRGFVIMFDKLNAVHLNGYTLEAEAGANLIETTKIAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEISHIFLSAKVLTPSGEIKTISARDMAFGYRHSAIQETGDIVISAKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSVFKRPPGHFAGQLIMEANLKGHRIGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETVENHSGVRLEPEVRIIGENL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGAT3_MOUSE
Sequence: MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLISSFFWNNAPVTPQASPEPGDPDLLRTPLYSHSPLLQPLSPSKATEELHRVDFVLPEDTTEYFVRTKAGGVCFKPGTRMLEKPSPGRTEEKTEVSEGSSARGPARRPMRHVLSSRERLGSRGTRRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAININHEFDLLDVRFHELGDVVDAFVVCDSNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTMDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRSLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDQFRYLLENPYREPKSTVEGGRQNQGSDGRSSAVRGKLDTAEG
What is the function of this protein?
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides.  Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc).  It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides (PubMed:25592972, PubMed:11986323).  The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan.  The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate (By similarity).  Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location.  Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation (By similarity).  In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage (PubMed:25592972, PubMed:26467158).
What are the official names of this protein?
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, GNT-III, GlcNAc-T III, N-acetylglucosaminyltransferase III.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 17 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: DJLA_SALTI
Sequence: MQYWGKIIGVAVALMMGGGFWGVVLGLLVGHMFDKARSRKMAWFANQRERQALFFATTFEVMGHLTKSKGRVTEADIHIASQLMDRMNLHGDSRTAAQNAFRVGKADNYPLREKMRQFRSVCFGRFDLIRMFLEIQIQAAFADGSLHPNEREVLYVIAEELGISRVQFDQFLRMMQGGAQFGGGYHQQSGGGWQQAQRGPTLEDACNVLGVKTTDDATTIKRAYRKLMSEHHPDKLVAKGLPPEMMEMAKQKAQEIQKAYELIKEQKGFK
What is the function of this protein?
Regulatory DnaK co-chaperone.  Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway.  The colanic acid capsule may help the bacterium survive conditions outside the host.
What are the official names of this protein?
Co-chaperone protein DjlA.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type III membrane protein.
Protein: Y1211_AQUAE
Sequence: MELLREFLRNYGERFKEELENLVKKYVQGEEDVVLLKMDERCLILPFLNVGDFFYMKARELTEPVKLEVLQKRDSEVLARAISYEETYIEKRQHVRVQPDKPIPVYIKEKDTVGSILDISVGGIGVFLKEKVVEPEEVVTLEFELEGEEIKTKGECRYTIPYRAGYRAGFKFVDLSTRYENIIGRYVMKRQMEILKELKESMI
What are the official names of this protein?
Uncharacterized protein aq_1211.
What is the protein family that this protein belongs to?
To A.aeolicus aq_820 and aq_1583.
Protein: CEDA_SALDC
Sequence: MMKPLRQQNRQIISYIPRVEPAPPEHAIKMDTFRDVWILRGKYVAFVLTGESFQRSPAFSVPESAQRWANQVRQENEIAD
What is the function of this protein?
Activates the cell division inhibited by chromosomal DNA over-replication.
What are the official names of this protein?
Cell division activator CedA.
What is the protein family that this protein belongs to?
Belongs to the CedA family.
Protein: SAHH_METNO
Sequence: MPSAQDYIVRDIGLADFGRKEIAIAETEMPGLMAVRREYAASQPLKGAKIAGSLHMTIQTAVLIETLKALGADIRWVSCNIYSTQDHAAAAIAAAGIPVFAVKGETLTEYWDYTAKLFEWHDGGMPNMILDDGGDATMFVHAGLRAERGDAVFLDKPGSEEEEIFFALIKRMLKEKPQGWFAGLAESIKGVSEETTTGVHRLYLLAREGKLLFPAINVNDSVTKSKFDNLYGCRESLVDGIRRGTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVLVSEVDPICALQAAMEGYEVTTMEDAAPRADIFVTATGNKDVITLDHMRAMKDRAIVCNIGHFDNEIQVAGLRNLKWTNIKPQVDEIEFADGHRIILLSEGRLVNLGNAMGHPSFVMSASFTNQTLAQIELWTNQGKYDRQVYTLPKALDEKVAALHLEKIGVKLTKLRPDQAAYIGVSENGPFKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AKTP2_DROME
Sequence: MWYSTVRNPSIALIKQGYHILAEYNLVKEELKNIYAIPSYACGLHWFGVIFVHSGIYAGSVFRFSILLPENFPADISLPTVVFSTEVLHPHICPQNKTLDLAHFLNEWRKDEHHIWHVLRYIQAIFADPEGSICTGQSSSGDLVIMDEVRNMNALNMLAKSRPEYIKRVQEQAILSRNLIYDRPPTEDPHYIIVEPYCAERHLKFMDQLKSPCWKEATSMDCSQPSEYLGHIDSSRQLDEEEANQVEKLHRGRIPEHQREESEVSL
What are the official names of this protein?
Protein crossbronx-like.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
Protein: RS16_BRUSU
Sequence: MALKIRLARAGSKKRPYYHVVVADVRAPRDGRFIETVGSWNPVLPKDAERVKLDAERIQHWIAQGAQPTDRVLRFLDQAGIAKRPSRNNPTKGEPGKKAQERLALAKQAEEEAAAKAAEAAAAAAAPAEEAASE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SLX1_PENRW
Sequence: MEEFEKPKPIPAYYCCYLLRSTVRHASLYIGSTPNPIRRLPQHNGVAKGGAKRTARDKLRPWEMTLVVEGFTSRVGALQFEWAWQHPERSRHLDSDDDLDSKPQAKANANADAKTGKPKSKPRARTRRSLMAHLEDLHSLLRSTYFSSWPLRVRFFCADVYRVWRAWNDRVDSRLPDMIKVILDGDNLATAPDTNQRDGHAPVGNINNLSIDYTRLEDHLEKSMFMLDDPDDLQCTVCKESISPNEEQIVVCPHPNCRGTSHLLCLSTKFLDATNETDLLVPTQGTCPSCGNTVQWVTMMRELSLRNRAEKEARAILRKKEKRVRKESAAMEGSSVPRSSSTEPRSLLEEPTQDDLGPNWFEEVDIESDSDVEGRQKHRSTQPPSKLEIVIEDSDWDDAELIE
What is the function of this protein?
Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit slx1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NTPPB_NEIMA
Sequence: MGLELPLILGTSSVFRREQMERLGIAFQAASPDFDETPMLGESAPQTALRLAEGKARSLAGRFPEALIVGADQVAWCDGRQWGKPMNLANAQKMLMHLSGREIEFYSAVVLLNTVTGRMQRHIDKTVVVMRKLDELHILRYLEREPDAVYCSCALKSEALGALLIERIESTDPNALIGLPVFRLVDFLKNEGVDVL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESXR_MYCTO
Sequence: MSQIMYNYPAMMAHAGDMAGYAGTLQSLGADIASEQAVLSSAWQGDTGITYQGWQTQWNQALEDLVRAYQSMSGTHESNTMAMLARDGAEAAKWGG
What are the official names of this protein?
ESAT-6-like protein EsxR.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. ESAT-6 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX-3 / type VII secretion system (T7SS).
Protein: NUOB_METNO
Sequence: MPMALDTSFSRAPAIAPQPKGIIDPATGLPVGATDPTFLSINDELADRGFLLTTADDLITWARTGSLMWMTFGLACCAVEMMQMSMPRYDAERFGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRVVPVDIYVPGCPPSAEALLYGVLLLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MAD1_ARATH
Sequence: MILRTPQPKRLRSDAGESPFPTGATGSGNQLIIYEDSPLPAPAPLQTSHDHSADQHLCTYQCRQMVKADVLDALSTAEKQVEESKTKLQTLNANFTEADAERKHFRDKFLYSEQELAAAKAREKMLQEQLLMEINNSQERYTKELQSCHELEVKLQNEMNLRKKAESSAATAEEKAKLLEDKLTQLSGSVDREKKRLNNDIAQLGKEAKLSVARIGADLERMQCRAQNAETESNLLRSQLEHLKLIFDECLQEKTEVDKKLSSFTSEAASSSDNSVLVKHLQEELKRYEAEVREARKLKSRHLDAELLNVNLLEEQSRRERAESELSKFHDLQLSMEKLENELSSWKSLLNDIPGVSCPDDIVMRFSVLQNEVVQSTMKIGEASTRIKQLEETLEAIQLGRQNAVSEAALAKEKSEALKTDVKRIEVMLTLVTEEKEQLKAVVNELRKSNSEGSVSGAADGALIQGFESSLAKKENYIKDLEQDLNQLKDVNNRQRTEIELLNEKLVDEARRNKSLERDSDRLRSEISLLESKLGHGDYSAANTRVLRMVNTLGVENEAKQTIEALQAELQKTKERLQAVEELKSQSGDAGKLVDSHITGKIAQLKEQNATLEKREERYKTVFADRISVFRRACCELFGYKIVMDEHQRPNGIPVTRFTLQSIYAQSDDEKLEFEYESGNTSILNNEYASQGDIAKQIEIFIRKFNSIPAFTANLTMESFNRRTLY
What is the function of this protein?
Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete.  It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.  Required for anchoring MAD2 to the nuclear envelope.
What are the official names of this protein?
Mitotic spindle checkpoint protein MAD1, Mitotic arrest deficient protein 1.
What is the protein family that this protein belongs to?
Belongs to the MAD1 family.
What are the subcellular locations of this protein?
Nucleus envelope. Note=The nucleus envelope association requires the presence of NUA.
Protein: TTC22_MOUSE
Sequence: MTEAEVGAEDLDTLLDELDYLPGHFHLEMQLNFEPRSPAQLRARDLKLQREGLRQELELVATPQLPAVRHLLGTFSFYLEELGDAREHFLEVARKDPGNLNAWANLAHVYGQLGQEEEEEASAGRLASLMGLEGDPEDAGDPRLRAARCLAEQGYAHGFDVGCASPEERAQVLEAGIALYDKALGYGQQIPIEEKRSWYFTMATLFIRLDGIFLEMGSEEQKRLPAFNRTLALLGEVLKSSDSRHQALAWCYVGMLLERKDTFSTTPMGVHEYGYSGTEPLDCFGKAIEIAKNQPPILNRLAKIFHFLGKQDMAVGTCNMVLAVLTDPELNWQAYCTRAKVRIRAYVHDLERAKVGLGGLPDRNHLACAKADLEEVVKVCPSLRTYLDISQVYYYMGVDAMRELLAVDEAALNQALVFLAKAGELELGDTLPELQLLRGKCLRVQGEDANAAACFKRAVELDDEGSSHTEGFGCLLEALLAQWSQAQLSDGEVGYEVDVWLRHAQGKYPAARLRQELQRVWRGHTEEVLGLARALVAQGRPALVRLLFETMEHEGEDAGGSGKSRVSS
What are the official names of this protein?
Tetratricopeptide repeat protein 22, TPR repeat protein 22.
Protein: CPSC_STRA5
Sequence: MNKIANTEVEINIFNLLKKLWKKKFLITFVAIAFATAGLFYSLFIVTPQYTSSTRIYVINPNTPNNSITAQDLQAGSFLANDYKEIITSTDVLEKVISSEKLNYPSSQLLQKITVSILKDTRVISISVEDANPKMSQKLANSVREAAVSKIKAVTQVEDITTLEKGNLPKAPSSPNIKKNVLIGFIVGAGLSTIVLVIMGILDDRVNTEEDIEKVLGLTSLGIVPDLNKL
What is the function of this protein?
Required for CpsD phosphorylation.  Involved in the regulation of capsular polysaccharide biosynthesis.  May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide (By similarity).
What are the official names of this protein?
Capsular polysaccharide biosynthesis protein CpsC.
What is the protein family that this protein belongs to?
Belongs to the CpsC/CapA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRUB_LISIN
Sequence: MNGIIPLWKERGMTSHDCVFKLRKILHTKKVGHTGTLDPEVEGVLPICIGRATKLAEYVTDEGKVYVAEITLGKSTTTEDATGETVATKELAEISAEELQAALTKLTGKITQIPPMFSAVKVNGKKLYEYARAGIEVERPSRQVDIYSLVRLDGVSPLTESNPTFKLEISCGKGTYIRTLAVMIGELLGYPAHMSKLERTRSGFFKKEDCLTLAEIDEKMQANDTDFLYPLEKGIESMAKLEIDEEIHAKVLNGVLLPKSLFQTVENEPRVALIFQEKLTAIYKPHPEKQDLFKPEKVIELQQA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RNPH_MYCGI
Sequence: MSRREDGRLDDELRPVTITRGFTTHPAGSVLVEFGETRVMCTASVTEGVPRWRKGSGQGWLTAEYAMLPAATHDRSDRESVKGRVGGRTQEISRLVGRSLRACIDLAALGENTIAIDCDVLQADGGTRTAAITGAFVALSDAVTYLGAAGKLSDPRPLSCAIAAVSVGVVDGRVRVDLPYTEDSRAEVDMNVVATDTGTLVEIQGTGEGATFPRSTLDKMLDAAMAACDQLFEIQRAALELPYPGTLPESAEPAKKAFGS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: ARC_STRRD
Sequence: MAARDDAEARAAQREREVADLTTQVSFLQEELTALRRKLTESPRQARVLEERLHEVQANLAAVTGQNERLVATLKEARDQIVALKEEVDRLAQPPSGFGVFLESREDGTVEVFTGGRKLRVNVSPAVEVDSLKRGQEVMLNEALNVVEALGFEELGEIVMLKELLEDGRRALVISHADEERVVKLAESLVGQPIRAGDSLLLEPRSGYVYERIPKSEVEELVLEEVPDISYEEIGGLMRQIEQIRDAIELPYLHADLFREHKLRPPKGVLLYGPPGCGKTLIAKAVANSLAKQVAEKTGQSGKSFFLNIKGPELLNKYVGETERHIRLVFQRAREKASEGTPVIVFFDEMDSIFRTRGSGVSSDVENTIVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAKDIFSKYLIEDLPLHPEDLAEHGGSRGGTISGMIQRVVERMYTESEENRFLEVTYANGDKEVLYFKDFNSGAMIQNIVDRSKKMAIKQFLESGQKGLRIQHLLAACVDEFSENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKQGTEAGRSIDTVANTGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Proteasomal ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: LPXC_SALA4
Sequence: MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFRPYNGFTLDFTIDFNHPAIDSSSQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDDAELPLAFKAPSTVLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: DGCF_ECOLI
Sequence: MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
What is the function of this protein?
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules.
What are the official names of this protein?
Probable diguanylate cyclase DgcF, DGC.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LYTN_STAAN
Sequence: MFIYYCKECSIMNKQQSKVRYSIRKVSIGILSISIGMFLALGMSNKAYADEIDKSKDFTRGYEQNVFAKSELNANKNTTKDKIKNEGAVKTSDTSLKLDNKSAISNGNEINQDIKISNTPKNSSQGNNLVINNNEPTKEIKIANLEAQNSNQKKTNKVTNNYFGYYSFREAPKTQIYTVKKGDTLSAIALKYKTTVSNIQNTNNIANPNLIFIGQKLKVPMTPLVEPKPKTVSSNNKSNSNSSTLNYLKTLENRGWDFDGSYGWQCFDLVNVYWNHLYGHGLKGYGAKDIPYANNFNSEAKIYHNTPTFKAEPGDLVVFSGRFGGGYGHTAIVLNGDYDGKLMKFQSLDQNWNNGGWRKAEVAHKVVHNYENDMIFIRPFKKA
What is the function of this protein?
Probably involved in peptidoglycan hydrolysis.
What are the official names of this protein?
Probable cell wall hydrolase LytN.
What are the subcellular locations of this protein?
Secreted.