PharMolix/UniProtQA huggingface dataset:
Protein: PANB_PSYCK
Sequence: MTTLSTLNKFKKDGTKFTCLTCYDAMFARMMEKAQIDTILIGDSLGMVVQGHDSTLPVTVDDMAYHTANIARSNKQALILADLPFMSYVTLPEAVVNSRKLMQAGAHVIKIEGGCELCELITTLAQAGTPTCVHLGLTPQSVNVFGGYKVQGRGNEAGQKLLDDAKAVVDAGAALLVLECVPAELAKAVTEAVAVPVIGIGAGADTDGQVLVMHDMLGMVHGRAPRFIHDFLTDERNTEHSIEGAFALYQQSVKEGSFPTEQHQFS
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLC11_HUMAN
Sequence: MQAAWLLGALVVPQLLGFGHGARGAEREWEGGWGGAQEEEREREALMLKHLQEALGLPAGRGDENPAGTVEGKEDWEMEEDQGEEEEEEATPTPSSGPSPSPTPEDIVTYILGRLAGLDAGLHQLHVRLHALDTRVVELTQGLRQLRNAAGDTRDAVQALQEAQGRAEREHGRLEGCLKGLRLGHKCFLLSRDFEAQAAAQARCTARGGSLAQPADRQQMEALTRYLRAALAPYNWPVWLGVHDRRAEGLYLFENGQRVSFFAWHRSPRPELGAQPSASPHPLSPDQPNGGTLENCVAQASDDGSWWDHDCQRRLYYVCEFPF
What is the function of this protein?
Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999).  Important for repair and maintenance of adult bone (By similarity).
What are the official names of this protein?
C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Osteolectin, Stem cell growth factor, p47.
What are the subcellular locations of this protein?
Cytoplasm. Secreted.
Protein: UBE2Z_XENLA
Sequence: MAESPAAEAIILPGAAAGGGVVPHLSGLQTPGTSLLTTSSVWDPSASADWDNERASTQCVLRIKRDIMSIYKEPPPGMFVVPDPHDMTKIHALITGPFDTPYEGGFFLFLFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSLSSVLISIQSLMTENPYHNEPGFEQERHSGDSKNYNECIRHETIRVAVCEMLEGKCQCPDALRSVMEKSFMEYYDFYEAVCKDRFHLQGQNMQDPFGEKRGHFDYQSLLSRLQTIHQRVREKHRRETVDIDSDSSSSETETDTQGSSNP
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  May be involved in apoptosis regulation.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 Z, E2 ubiquitin-conjugating enzyme Z, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: COX1_LATCH
Sequence: MMITRWLFSTNHKDIGTLYMIFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTVINMKPPTMTQYQTPLFIWSVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGVTKWDTPLLWALGFIFLFTVGGLTGIVLANSSLDIILHDTYYVVAHFHYVLSMGAVFAIMGGLVHWFPLMTGYTLHNTWTKIHFGVMFTGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSLISLIAVIMFMFILWEAFSAKREVLIVEMTTTNVEWLHGCPPPHHTYEEPAFVQAPR
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SYM_NEIG1
Sequence: MTRKILVTSALPYANGSIHLGHMVEHIQTDVWVRFQKLRGHECYYCCADDTHGTPVMLAAQKQGIAPEDMIAKVRKEHLADFTGFFIGYDNYYSTHSTENKQFSQDIYRALKANGKIESRVIEQLFDPEKQMFLPDRFVKGECPKCHAQDQYGDNCEVCGTTYSPTELINPYSAVSGAKPELRESEHFFFKLGECADFLKAWTSGNNPHDGKPHLQPEALNKMKEWLGEGEETTLSDWDISRDAPYFGFEIPDAPGKYFYVWLDAPVGYMASFKNLCDRIGIDFDEYFKADSQTEMYHFIGKDILYFHALFWPAMLHFSGHRAPTGVYAHGFLTVDGQKMSKSRGTFITAKSYLEQGLNPEWMRYYIAAKLNGKIEDTDLNLQDFISRVNSDLVGKYVNIAARASGFIAKRFEGRPKDVSGSALLAKLAAESDTIAEQYENREYARALRDIMALADIVNEYVDANKPWELAKQEGQDERLHEVCSELINAFTMLTAYLAPVLPQTAANAARFLNLDAITWKNTRETLGEHAINKYEHLMQRVEQKQVDDLIEANKQSIQTASAPVEEGKYEKVAEQAGFDDFMKIDMRVAKVLNCEAVEGSTKLLKFDLDFGFEKRIIFSGIAASYPNPAELNGRMVIAVANFAPRKMAKFGVSEGMILSAATADGKLKLLDVDAGAQPGDKVG
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFYB_RAT
Sequence: MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVSATDGLSEELTEEAFTNQLPAGLITADGQQQNVMVYTTSYQQISGVQQIQFS
What is the function of this protein?
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.  NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
What are the official names of this protein?
Nuclear transcription factor Y subunit beta, CAAT box DNA-binding protein subunit B, CCAAT-binding transcription factor subunit B, CBF-B, Nuclear transcription factor Y subunit B, NF-YB.
What is the protein family that this protein belongs to?
Belongs to the NFYB/HAP3 subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: POL_CAMVS
Sequence: MDHLLLKTQTQTEQVMNVTNPNSIYIKGRLYFKGYKKIELHCFVDTGASLCIASKFVIPEEHWVNAERPIMVKIADGSSITISKVCKDIDLIIAGEIFRIPTVYQQESGIDFIIGNNFCQLYEPFIQFTDRVIFTKNKSYPVHIAKLTRAVRVGTEGFLESMKKRSKTQQPEPVNISTNKIENPLEEIAILSEGRRLSEEKLFITQQRMQKIEELLEKVCSENPLDPNKTKQWMKASIKLSDPSKAIKVKPMKYSPMDREEFDKQIKELLDLKVIKPSKSPHMAPAFLVNNEAEKRRGKKRMVVNYKAMNKATVGDAYNLPNKDELLTLIRGKKIFSSFDCKSGFWQVLLDQESRPLTAFTCPQGHYEWNVVPFGLKQAPSIFQRHMDEAFRVFRKFCCVYVDDILVFSNNEEDHLLHVAMILQKCNQHGIILSKKKAQLFKKKINFLGLEIDEGTHKPQGHILEHINKFPDTLEDKKQLQRFLGILTYASDYIPKLAQIRKPLQAKLKENVPWRWTKEDTLYMQKVKKNLQGFPPLHHPLPEEKLIIETDASDDYWGGMLKAIKINEGTNTELICRYASGSFKAAEKNYHSNDKETLAVINTIKKFSIYLTPVHFLIRTDNTHFKSFVNLNYKGDSKLGRNIRWQAWLSHYSFDVEHIKGTDNHFADFLSREFNKVNS
What is the function of this protein?
Encodes for at least two polypeptides: protease (PR) and reverse transcriptase (RT).  The protease processes the polyprotein in cis.  Reverse transcriptase is multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated, and reverse-transcribed inside the nucleocapsid.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA) (By similarity).
What are the official names of this protein?
Enzymatic polyprotein.
What is the protein family that this protein belongs to?
Belongs to the caulimoviridae enzymatic polyprotein family.
Protein: PRIM_ALHV1
Sequence: MTRVVKALFAADTDCAELLADILTGQNNSGSLYCLLHNCRPEDVSWEVTRLSLCLPVRRPGGAEGRCAEVFKIKLPTEEAGQFLFNCGSLSAKQVYESYSKRAAYETFQPILEVLGLSGDEYSIKNAVTWGRGKFVASLRKYFKLTTSPHWFINTFGAFENHFVLVSSCYYFFPVSVSTVDTLCHLAMLYSSKKGCPLSSITTLRELGAVATQSPALDRVENFYLYVCDKLARDTLECEAVDRCINEFRGQLMLSDQDLVHYIYLSFFQCFNNQKFLAYSQCTNPCNLNTTMLREPMLVANIDSDFKHKMATYYNKNTYLSNYVLLRGIHLHPVVGYGQECLRSAHATGGHSIWWGESHQVSDMLKTINVEYPDICLHEEFRGLMDLAAITDRCSIFGNPIHYLTDCATSGAIPIYRSELSHRHYFLAVFSDDIEYFWKKTIFLPPESFCLGAQDTMLTRAITYTEMHCSMSSVAEQIHVSRHEYFNPKLPVFNWVLDLDLPISEGNLHIDSIYSLCLLIRESVLDILKLLGPVEPDHEVFFFKSACINLCDPGEASWRPSTFCTCTEKLGMRVVTRFPPGICLKGSEPLTQLTKILNRVIKLGCGSLLNLSAFQLSNGPFDVGIYGRGRSIRLPHTYKVGKCGQLERLLKLFVCHPEATDKFPYLQNSLKLNRLLHHAQSQDPRGPLKIIYRVEDINEDFLYKHTQKQLPVKHEAVIPSIERLLDTSLNCFLLSKVWPKCFGTIRSYMSEEKLQQFSRVVFHPTNHCIVQVRPDRGNNFKCLRYNHRGSSKSVRVFLILHLKEETKLIVTFMSQCFANKCQSNKAMAHFSVFVDLS
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Protein: MRAZ_ENT38
Sequence: MFRGATLVNLDSKGRLSVPTRYRDQLIENASGQMVCTIDINHPCLLLYTLPEWEIIEQKLSRLSSMNPQERRVQRLLLGHASECQMDNSGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSDSGVLSDRLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CLPS_VIBPA
Sequence: MSKNFEWVTPDSDLLERESTKVQPPKLYNVVLNNDDYTPMDFVIEVLERFFSHDIDKATQIMLKVHYEGKAVCGTYSAEIAETKVAQVTMYARENEHPLLCTMEQA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RIB7_SACS2
Sequence: MVMKPYVIIFSTVSIDGRLATKTGYSELSCPYDKQRQHEIRSEVDAVMVGANTVRVDNPSLTVKYGKNRRNPIRVVVTRSFNLDPSYKIFTTPPSTVIYTSNYESEKVEEFIRKGVIVRKFLHLDDLLEDLYDNFNVRRLMVEGGGHLIWWFIKDNLYDEIRITISPRIFGNGVSFTQGEGFIGEDSPRLELIDAKICECGNEVHLTYKKYMT
What is the function of this protein?
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
What are the official names of this protein?
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, DAROPP reductase, DARP reductase, 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase, 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase, DARIPP synthase.
What is the protein family that this protein belongs to?
Belongs to the HTP reductase family.
Protein: RSGA2_ARATH
Sequence: MQTFSSAAALTSILRRTTIYHGGFGTGLRIRRSFYFLSAIRQENPNVTKNPHPNKTILRSFLAPVLPLDEKPNLVELQAIGTIATALADYMRVIVQDVPESDNGEDDKIGVELLCVVRKLLKKIGRTVLVGDKVLVDKVDWVDRRAKIINVFDRVSEVLDPPVANVDHLVILFSLDQPKIDPFTLTRFLVEAESIGIRITVALNKCELVTQEEVESWKIRLRSWNYEPLFCSVGTKVGIDEIAFNLRNQTSVIVGPSGVGKSSLINILRSSYGGDIKHEEVFKPVSFFLSYFIL
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MNMA_NEIM0
Sequence: MNTTANTTNIIVGLSGGVDSSVTAALLKQQGYQVRGVFMQNWEDDDNDEYCSIKQDSFDAIAVADIIGIDIDIVNFAAQYKDKVFAYFLQEYSAGRTPNPDVLCNAEIKFKCFLDYAVGQGADTIATGHYARKEVRNGVHYLLKGLDRNKDQSYFLYRLKPFQLERAIFPLGGLEKPEVRRLAAEFNLPTAAKKDSTGICFIGERPFREFLQKYLPTDNGKMVTPEGKTVGEHVGLMFYTLGQRKGLGIGGAGEPWFVAAKDLTKNELIVVQGHDHPLLYTRSLVMNDLSFTLPERPKAGRYTCKTRYRMADAPCELRYLDDETAELVFDEPQWAVTPGQSAVLYDGDICLGGGIIQTTDKPVIITR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNT6B_XENLA
Sequence: MGTIYLFRKTQRSLLGKLTQEFRLVTADRRSWKILLFGAINVVCTGFLLTWCSSTNSMALTAYTYLTIFDLFSLITSLISYWVMMKKPSPTYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALFFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGVIPGLSSIFLPRMNPFVLIDIAGALALCITYMLIEINNYFAVDTASAIAIAVMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLLREVSTLDGVLEVRNEHFWTLGFGTMAGSVHVRIRRDANEQMVLAHVTNRLSTLVSTPTVQIFKDDWARPVLASGTMPPNMLNIPEHHVIQMPSLKSTVDELNPMTSTPSKPSGPPPEFAFNTPGKNMNPVILSNNQTRPFGVGYGTTPYTTTFNQGLGVPGVGNTQGLRTGLTNVANRYGTYTPGQFTQFRQ
What is the function of this protein?
Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway.  As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
What are the official names of this protein?
Zinc transporter 6-B, ZnT-6-B, Solute carrier family 30 member 6-B.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles.
Protein: SHR3_YEAST
Sequence: MFSYSDFCSIGTAMILSATTFLMGVFFSNMPYDYHLLFNPNSTQEHFDLALRHYQILHETPLPVIVTLCVVAGIGLVGGTIKVFKPNPELQMFEYCSLGLYVLAICVFLTNVKTGIDCSVSHNWGEVTENQGLAVIASSNIILLVMFAGVIILQIGLWYSNWDLQKRLKEFYAQEEREAANAGKKTEKVDNAKKNDNKSKGAQKRKNAKK
What is the function of this protein?
Involved in amino acid permease processing and required for the efficient translocation of structurally related amino acid permeases from the endoplasmic reticulum to the plasma membrane.  SHR3 may function as a permease-specific 'adaptor' molecule that functions in conjunction with the SEC62/SEC63 complex.  Yeast cells may require SHR3 to expedite the processing of permeases to ensure their rapid expression at the plasma membrane in response to changing environmental conditions.
What are the official names of this protein?
Secretory component protein SHR3.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PTH_BACAN
Sequence: MKLIVGLGNPGREYELTRHNIGFMAIDELAKRWNISLNEQKFKGLFGAGFVNGEKVILLKPLTYMNLSGESIRPLMDYYKIDVEDFVVLYDDLDIPVGKLRLRMKGSAGGHNGVKSTISHLGTQEFQRIRMGIDRPKNGMKVVDYVLGRFTSEEIPDVNHSIEKAADACEEWLNKPFLQIMNTFNS
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMJ_YERPP
Sequence: MSHVSICLLSEAGADPGALSILADRWGLVSDDQAVMALVLTAERLELRKRDEPKLGGIYVDFVSGTQAHRRKFGGGRGEAVAKAVGIKKGYLPRVVDATAGLGRDAFVLAALGCQVQMLERNPVVAALLDDGLRRGYLDAEIGPWLRERLTLLHASSLTALVAIEPRPEVVYLDPMYPHRQKSALVKKEMRVFQSLVGADNDADGLLAPARALATKRVVVKRPDYAEPLAGVAAQAAVVTKSHRFDIYPSSVTPPR
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBX8_BOVIN
Sequence: MGQGLWRVARNQQLQQEGYGEQGYLSREQSRRVAASNMSHTSHRKHVQGGIDIYHLLKTRKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA
What is the function of this protein?
May promote guanine-nucleotide exchange on an ARF.  Promotes the activation of ARF through replacement of GDP with GTP (Potential).
What are the official names of this protein?
F-box only protein 8.
Protein: Y1459_PYRHO
Sequence: MNLVFGMIASIGELLIDLISVEEGDLKDVRLFEKHPGGAPANVAVGVSRLGVKSSLISKVGNDPFGEYLIEELSKENVDTRGIVKDEKKHTGIVFVQLKGASPSFLLYDDVAYFNMTLNDINWDIVEEAKIVNFGSVILARNPSRETVMKVIKKIKGSSLIAFDVNLRLDLWRGQEEEMIKVLEESIKLADIVKASEEEVLYLENQGVEVKGSMLTAITLGPKGCRLIKNETVVDVPSYNVNPLDTTGAGDAFMAALLVGILKLKGLDLLKLGKFANLVAALSTQKRGAWSTPRKDELLKYKEAREVLAP
What are the official names of this protein?
Putative sugar kinase PH1459.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: HTYC_ASPRU
Sequence: MVKTFDIVVFPGDYGGPEVLGEIQSQYEQEVTFNLKYHLLGGASFDAHGTPIADEALTDAKAASAVLLGAVGGPAWDKAPIPVESGLGRLRKALDAFGNLRPVKFIHPILTETSALKEQVCRGADLLIIRELTGGIYYGARQEHDGTLNAASDLDHYERAQVQRVARLAGTLAMSTQPPTPITSLDKANLLAACGRLWRGVVEETIRREFPDVELKHMLIDTAAMTLGCRPTKLNGIVLTSNMFGDIISDQASAIPGSLGLLPSASLCAIPGGESGGCVHGIYEPVHGSAPDIAGQGIINPTGMILSVAMMLRYSLDMPAAATAVETAVSRVIERGGRTRDVGGTTSTAEFGDQVVACLRENTEDK
What is the function of this protein?
Isopropyl malate dehydrogenase; part of the gene cluster that mediates the de novo generation of L-homotyrosine from acetyl-CoA and 4-hydroxyphenyl-pyruvate (PubMed:22998630).  L-homotyrosine is a building block of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent (PubMed:22998630).  L-homotyrosine 4-hydroxyphenyl-pyruvate first undergoes an aldol-type condensation by htyA with the C-2 of acetyl-CoA followed by the release of CoA to form 2-(4-hydroxybenzyl)-malate (PubMed:22998630).  This is followed by isomerization of 2-(4-hydroxy-benzyl)-malate to 3-(4-hydroxybenzyl)-malate by htyD (PubMed:22998630).  Thereafter, 3-(4-hydroxybenzyl)-malate undergoes decarboxylation and oxidation to form 2-oxo-4-(4-hydroxybenzyl)butanoic acid, coupled to reduction of NAD(+) to NADH by htyC (PubMed:22998630).  The product then undergoes transamination catalyzed by htyB to form L-homotyrosine (PubMed:22998630).
What are the official names of this protein?
Isopropyl malate dehydrogenase htyC, L-homotyrosine biosynthetic cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Protein: PACC_TRIRU
Sequence: MQSASSLQQQQPQQQQQQQPQQQGQQQGQQAQQQQGQQQQPASQTVQSVPVQANLQHAAAAAAAVAPPGVQQVAPNSPSAPGSLECQWQGCQELCPTPEALYEHVCERHVGRKSTNNLNLTCGWSNCRTTTVKRDHITSHIRVHVPLKPHKCDFCGKAFKRPQDLKKHVKTHADDSVLMRSPEPGAGQRQQPPAGMFGVGLGPDGKRSLGPVPQAYGHPPPQYYQPQHPQQQPNPSYGNVYYAVGHDAAHQASYESKKRGYDALNEFFGDLKRRQFDPTSYAAVGQRLLNLHGLPLPLTHAGAVPEYQPMPAMVGVGGGHGGYQSAGPIPTQSYHLPPMGNLRTKADLMNIDQFLEQMQSTVYESDENVAAAGVAQPGAHYVQGPLSYRTTNSPPTHHQSHHQHPHATATAAATTTAATTASMMSTSAAATPASSISAASRSPHASTPALTPPSSAQSYTSGRSPISLASSHGMSPSHHPSTAGMYPTLPATTGQDSLSSSGYPTTVSSAAPPSTLSSVFDDDRRRYTGGMLQRSRPDIDLSTPSIKRDDADATAGKDEPKLSSSVIDPALSRASVDMDEDAAPHRSPSSTPTPTATTAAAGPDDRQPAGEQQWVENVRLLQRLRDYVLERLNNGDYVDEDKQDDSDKEEDAKSDKASPESASASDAATGAGEYPSIKMHGMEAIAAAAVAHEEGRDDQMPRDDEDQENPSTPTARSTTTMLDAEEEAKQAGENLYPVLKMAVDDDGADTDGDEKMGQ
What is the function of this protein?
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH.  At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes (By similarity).
What are the official names of this protein?
pH-response transcription factor pacC/RIM101.
What is the protein family that this protein belongs to?
Belongs to the pacC/RIM101 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PFKA_BACAC
Sequence: MKRIGVLTSGGDSPGMNAAIRAVVRKAIFHDIEVYGIYHGYAGLISGHIEKLELGSVGDIIHRGGTKLYTARCPEFKDPEVRLKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEQGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTYVIEVMGRHAGDIALWAGLADGAETILIPEEEYDMEDVIARLKRGSERGKKHSIIVVAEGVGSAIDIGKHIEEATNFDTRVTVLGHVQRGGSPSAQDRVLASRLGARAVELLIAGKGGRCVGIQDNKLVDHDIIEALAQKHTIDKDMYQLSKELSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2245_ARATH
Sequence: MTTRGSRSEKVKRIFQQFDGNLDGGLSREEMSALVVAVNPRVKFSDEQISAILDEVFRTYAEFIDGDKGLTFDGLLRTYDDGAGDVDRDFDALGIEFNEETKGASEASSSSITDERAVEAQKQQRTAAWAVSPNHGIVFDETWKLVDDLEILVKRLKSKQEKDGKLKVDNNNVDAFSEAGWSRELGPSSDISDKRIYWEESSHDYGVFVKELGVLRSKADGARSREEAFDGHMAIGKVLYEHQLFKEALVSFKRACELQPTDVRPHFKAGNCLYVLGKYKESKDEFLLALEAAESGGNQWAYLLPQIYVNLGISLEGEGMVLSACEYYREAAILCPTHYRALKLLGSALFGVGEYRAAVKALEEAIYLKPDYADAHCDLASSLHAMGEDERAIEVFQRAIDLKPGHVDALYNLGGLYMDLGRFQRASEMYTRVLAVWPNHWRAQLNKAVSLLGAGETEEAKRALKEALKMTNRVELHDAVSHLKQLQKKKKVKKGNSANEEGPFIVVESSKFKTVGEKTTLRPDLAIALQVRAFQRVTRLWKCDVEALRREMRDNNVPVSYSGNGIPTKSIRRPNLEEILRRLLNVLKPETFQGAIKAINEKILSVLDDSGSGRVDLGMFYAVIAPLCGGHPDKRKRVAFDALLWKPVNEGSSQITKMEAVKYIKLLRAIYIPSQGMSEMLEVHGESDDTSTVTFNQFLEMYDDSEWGFGIMSTVFKLETRDRNRHGNQVCSVCRYPIIGSRFKEVKTGFSLCNQCYSEGKIPPTFKQQEEYKFREYASEVEAMKAKCVCFSMQSHKKTIAT
What are the official names of this protein?
Uncharacterized TPR repeat-containing protein At2g32450.