PharMolix/UniProtQA huggingface dataset:
Protein: NEF_HV1J3
Sequence: MGGKWSKRSVVGWPAVR
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Host cytoplasm, host perinuclear region. Virion. Secreted. Note=Predominantly found in the paranuclear area, probably in the TGN. Correct localization requires PACS1. Also associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Also incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved (By similarity).
Protein: CYB_TAMAM
Sequence: MTNIRKTHPLIKIINHSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTYFETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVMVHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDILGALLLILILMILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILMLFPILHMSKQRSMMFRPLSQCMFWILVADLFTLTWIGGQPVEYPFIIIGQLASILYFMIILVILPAISLFENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: QUEF_ECO45
Sequence: MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELEYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKVSVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATSGEKVVEETLVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAMP3_HUMAN
Sequence: MPRQLSAAAALFASLAVILHDGSQMRAKAFPETRDYSQPTAAATVQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITYTLVTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTGNTTQPSNQTTLPATLSIALHKSTTGQKPVQPTHAPGTTAAAHNTTRTAAPASTVPGPTLAPQPSSVKTGIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNIDPNATQASGNCGTRKSNLLLNFQGGFVNLTFTKDEESYYISEVGAYLTVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHFGNVDECSSDYTIVLPVIGAIVVGLCLMGMGVYKIRLRCQSSGYQRI
What is the function of this protein?
(Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium.
What are the official names of this protein?
Lysosome-associated membrane glycoprotein 3, LAMP-3, Lysosomal-associated membrane protein 3, DC-lysosome-associated membrane glycoprotein, DC LAMP, Protein TSC403.
What is the protein family that this protein belongs to?
Belongs to the LAMP family.
What are the subcellular locations of this protein?
Cell surface. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752).
Protein: TRHO_STRSY
Sequence: MSKDIRVLLYYKYVPIENAKEYAAEHLAFCKSIGLKGRILIADEGINGTVSGDYETTQKYMDYVHANPLFSDLWFKIDEENEQAFKKMFVRYKKEIVHLGLEDNDFDNDIDPLVTTGAYLSPKEFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVRGELWDGKMYVFDERIAVDVNHVNPVVVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEHKYVRGCSAECRAHERNRYISENGLTRQEWAERLEAIGETLTPANA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: TRPA_NEIMB
Sequence: MSRIRQAFAALDGGKALIAYITVGDPDIRTTLALMHGMVANGADILELGVPFSDPMADGPVIQRAAERALANGISLRDVLDVVRKFRETDTQTPVVLMGYLNPVHKMGYREFAQEAAKAGVDGVLTVDSPVETIDPLYRELKDNGVDCIFLIAPTTTEDRIKTIAELAGGFVYYVSLKGVTGAASLDTDEVSRKIEYLHQYIDIPIGVGFGISNAESARKIGRVADAVIVGSRIVKEIENNTGNEAAAVGALVKELKDAVR
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: SYM_STAAR
Sequence: MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDLANDLGNLVNRTISMINKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLEQYGVLTEPIMVTGQPKPIFPRLDSEAEIAYIKESMQPPATEEEKEEIPSKPQIDIKDFDKVEIKAATIIDAEHVKKSDKLLKIQVDLDSEQRQIVSGIAKFYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYN_HELPO
Sequence: MNFLRRRFSSGDLQGEANEKEDPPNVGILNFKKGPSPSAPNSPSKSASPATIGQKLFSGTVGVKPVSKDRYKTLLVIDGQHTDWSKYFKGKKLFGDWDVKVEQAEFSELNLASNSETGTTVEIQAIRNGNKTTRSLKPDFLLIRQHVRDAKVDWRHLLLGFRYGGVPSINSLTAEFNFLDKPWVFAQLIDIQKRLSKDVFPLIDQTYFSNHEEMLNSPKFPLVVKIGHAHRGLGKIKVDNVQTLEDLASVMATMSSYATTEPFIDSKYDIHVQKIGTNYKAYLRKSIAGNWKANTGSAMLEQIPMDERFKLWADECSQLFGGLDVVSVEAIQGKDGRDHIIEVNGSSMALLGEAQEEDRRLISEMVMAKMQMMCKPAQQPLSKASSSQSITPQANGAQKPVLAASPSRQAQGRPLDTSAQATPGQARGPPSSGGLPGVSNSQTPLSNQPSHLSNPPPQPFPTSTSGPQGLPRMASKDEEDTMKNLRKTFAGIFGDV
What is the function of this protein?
Neuronal phosphoprotein that coats synaptic vesicles.  Plays a role in the establishment of functional synaptic connections and in the regulation of their activity-dependent short-term plasticity.
What are the official names of this protein?
Synapsin, helSyn.
What is the protein family that this protein belongs to?
Belongs to the synapsin family.
What are the subcellular locations of this protein?
Synapse. Cell projection. Note=Localized in the contact area between the pre- and postsynaptic cells and in varicose structures along presynaptic neurites projecting onto the postsynaptic cell.
Protein: ATG15_YARLI
Sequence: MKQDLYKESSPPPSTTKSKGLYVIVAALVTTAIYLLYSQGYSNTHGEKDMPSVVPNLVLPANPSSDHSFAVKHIYHHNTEADANHGRMDVSGEWVRAAQKAQHLNLGQDTHRYMASNARDPYTNLPLKSRTQKVKRWRQRDPDHVESYLEAARLNPQLYGAMDFDWVEEDILVPDVTDRDTVVSLAVMASNAYVDVPFTGDWTNVSWKETGGIGWQSDGVRGHIFVDQTPGSPLVVIALKGTSAAIFDSGGDTVINDKTNDNLLFSCCCARVSYLWNTVCDCYTGESYTCDQECLEKELYAEDRYYRAVLDIYRNVTHLYPQKQIWVTGHSLGGALSAMLGRTYGIPAVGYEAPGELLPTKRLHLPSPPGIPWSQEHIWHFGHTADPIFMGVCNGASSSCSIGGYAMETSCHSGLQCMYDVVTDKGWHLSMVNHRIHTVIDEVLLAYNETAACVPPPPCQDCFNWNFVMGNDKDDDDKDKKKKKKTSTSSSVVSKTKTSTSSTVATNTMPSLPDPTCVERNWYGKCIRYDPEIKQQYGDSHTVTHVTMA
What is the function of this protein?
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies.  Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles.  The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
What are the official names of this protein?
Putative lipase ATG15, Autophagy-related protein 15.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Protein: KRUP_DROME
Sequence: MSISMLQDAQTRTLAAALAGIKQEDVHLDRSMSLSPPMSANTSATSAAAIYPAMGLQQAAAASAFGMLSPTQLLAANRQAAAFMAQLPMSTLANTLFPHNPAALFGAWAAQQSLPPQGTHLHSPPASPHSPLSTPLGSGKHPLNSPNSTPQHHEPAKKARKLSVKKEFQTEISMSVNDMYHTSGGPISPPSSGSSPNSTHDGAGGNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQNHERTHTGEKPFECPECHKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNGEKPFECERCHMKFRRRHHLMNHKCGIQSPPTPALSPAMSGDYPVAISAIAIEASTNRFAAMCATYGGSNESVDMEKATPEDDGPLDLSEDGASSVDGHCSNIARRKAQDIRRVFRLPPPQIPHVPSDMPEQTEPEDLSMHSPRSIGSHEQTDDIDLYDLDDAPASYMGHQQH
What is the function of this protein?
Krueppel is a gap class segmentation protein.  It is involved in the segmentation of the embryo and in the differentiation of the Malpighian tubules.
What are the official names of this protein?
Protein krueppel.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Note=Chromatin associated.
Protein: GLGA_CALBD
Sequence: MKILFAVSEAFPFAKSGGLADVAYSLPKALRNLGVDIRVIMPKYSDIHPDFTTKMKHICHFTVPVGWRNQYCGIEYLNLDGVPFYFVDNEYYFKRPGYYGYYDDGERFSFFSRAVCEAVYHLDFDVDIIHVNDWHTSVIPVLLKAHYGHSDKHNKIKTILTIHNLKYQGIFPKEVMYDLLSLPDEYFSEDKLKFYDAISFLKGGIIYSDKVVTVSRTYANEVRTLSYGEGLHGLLSGIGEKLIGIINGIDYEVYNPATDKLIFVNYDSNTFENRKKENKFRLQQMLNLPVSDEIVLIGMVSRLTKEKGIELIERIINKLLTLPVQLVILGAGDYHYEQMLKQYAGAFPSKVSANICYSEELARKIYAGSDMYLMPSLTEPCGISQLIAMRYGSVPIVRETGGLKDTVKPYNQFTGEGWGFSFANYDPAELFATIKYALSIYNDKNQWRNIVHQAMTQDNSWNASAYEYQKVYESLLNS
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: GCH1_SHEPC
Sequence: MALSEAAVKVQAALLERGLETPMLPSVYSSEERKDKIEHHMKEILTLMSLDLSDDSLADTPRRIAKMYVDEIFSGLDYENFPKITVIDNKMGFDEMVRVQDISLTSTCEHHLVTIDGTATIAYLPRKKIIGLSKINRIVRFFAQRPQVQERLTQQVLVALQTLLETKDVAVKMDAVHYCVKSRGVMDSTSSTTTTALGGIFKSNPATRAEFLHQ
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: SERP2_MOUSE
Sequence: MVAKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQIIQSIRMGM
What is the function of this protein?
May interact with target proteins during translocation into the lumen of the endoplasmic reticulum.  May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).
What are the official names of this protein?
Stress-associated endoplasmic reticulum protein 2, Ribosome-associated membrane protein RAMP4-2.
What is the protein family that this protein belongs to?
Belongs to the RAMP4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: XER_UREPA
Sequence: MKDFIRYTKKRNLSLNTIRTYESVLKHYEPVLDSWIKIRNKIINSNFKPRTIHLHKNVLLSFFEFKKLKRYLQNLKLLKLPQIEMKYFDVISKNNLYKKTDILDDDSLEIKKYKTIIRFLFETGIRAHELFFLESINNRLYVLGKGNKKRQIFFVKQTFEQLQKFYENLKGFETTKTLRLYIKKIIGKNFTPHSLRRSFATFMLIKGANPKTVMLQMGHANIQTTFSYLNLNEQTNRRIYNKIMYQNDAE
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.
What are the official names of this protein?
Tyrosine recombinase UU222.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_ACIF5
Sequence: MTSVHSLGFPRIGHKRELKKALESFWSREIDEQELQSRAAQLRDRHWRIQQTCGMDLVPVGDFSLYDHMLDMSCTLGAIPPRYGFAGGQVGLDTFFAMARGSATQPAMEMTKWFDTNYHFIVPEFHEGMDFRLSSERLFDQVKEVQALGLKAKPVLVGPITYLWLGKEKDLNAEAHHDAQHHHDDSACHGHGAPIGAACFDRLTLLPKVLPVYAEILARLAEMGVEWVQIDEPALALDLPQEWVEALESAYQTLRRDKTPKVLLATYFDSVADHAKALKALPVAGVHLDLRRAPQQLNSFLSDYPADKVLSLGVVDGRNVWRADLDAALELLQPAHKQLGDRLWVAPSCSLLHTPVDLEQETELDAELKSWLSFSVQKLDEVAIIGRALKEGVESVAQELAAARAAVASRKSSPRIHNPAVAQRLEGLGQDDGRRKSPFPIREAAQRARFKLPAFPTTSIGSFPQTPEIRKARLQNRKGELSNADYQKAMEAEIALVVKEQERLGIDVPVHGEPERNDMVEYFGEQLAGFAFTRHGWVQSYGSRYVKPPLIFGDVSRPTPMTVAWSKYAQSLTQRPMKGMLTGPVTILQWSFVRDDQPRERTALQIALAIRDEVRDLIDAGIGIIQIDEPAYREGLPLKRKDWGHYLEWASRAFRISAQIAPDDVQIHTHMCYSEFNDILPAIAAMDADVITIETSRSQMELLDAFATFNYPNEIGPGVYDIHSPRVPSVEEMVGLMEKAVKVVPAERLWINPDCGLKTRKWAEVTPALENMVEAARQVRARHG
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: COMEB_BACSU
Sequence: MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYNGSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCCKSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGLIGKLADAGLAEEELKKIHEQANTLFTSYV
What is the function of this protein?
Dispensable for transformability.
What are the official names of this protein?
ComE operon protein 2.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: Y1330_VIBPA
Sequence: MRQGTFFCIDAHTCGNPVRLVAGGVPPLEGNTMSEKRQYFLEHYDWIRQALMFEPRGHSMMSGSVVLPPCSDNADASILFIETSGCLPMCGHGTIGTVTTAIENRLITPKEEGRLILDVPAGQIEVHYQTKGDKVTSVKIFNVPAYLAHQDVTVEIEGLGEITVDVAYGGNYYVIVDPQENYAGLEHYSPDEILMLSPKVRTAVSKAVECIHPNDPTVCGVSHVLWTGKPTQEGATARNAVFYGDKALDRSPCGTGTSARMAQWHAKGKLKSGEDFVHESIIGSLFNGRIEGITEVNGQTAILPSIEGWAQVYGHNTIWVDDEDPYAYGFEVK
What are the official names of this protein?
Uncharacterized protein VP1330.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: ACPS_CAMJ8
Sequence: MRVGCDIIAISRIEKIHSRHGKNFLDKFLSPKEQILIKNPATLAGLWAAKEAASKALGVGICELCSFFDIEISKDEKNAPKLKYSQKITKNFNITQTSLSISHDNGFAIAIVAIV
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_PARXL
Sequence: MKSARRRSRELATQGLYQWLLSGSPGGEIDAQLRGAQGFDKADHEHLDAVLHGVIRDSEALSAAIAPCLDRPIEQLSPVERAVLLVAAFELKNHLDIPYRVVINEAVELAKTFGGADGYKYVNGVLDKLSAQLREDETQAARKR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RPTOR_DICDI
Sequence: MDKSYNFSSSNLANSSGLHNSINSNNVNGVNNINNNNNNNNNNNNNNNNNNNNENVNNHNNVSNISNTHQQAKKKEKYNNNNNKNKPFFGEERHKDNATPDVQKTKIAKWRMRERMKTVSVALVLCLNIGVDPPDVIKTFPCARMECWFDPSTQPPQKALDLIGKTLQAQYEKWQSKARYKQSLDPTVEEVKKLCLSLRRNAKDERVLFHYNGHGVPKPTTNGEIWVFNRNFTQYIPLSIYELQTWMGTPSIYVFDCSAAGLIINWFNQFAEQRDKELERFSGNNQNNNQNNNQNSNQNNQNNTTNSTNGNTNGNNQQNNNNSNNNSSNNSNTNSPNMGSSNSVNNNQSGSSSSSSHQRDCILLAACSANEILPMNPDFPADMFTACLTTPIRIALRWFCSHSILTGITADMLDKIPGNLSSRRTPLGELNWIFTAVTDTIAWNVLPRHLFQKLFRQDLLVASLFRNYLLAERIMRSANCTPISCPRLPPTYQHAMWQAWDLAVDLVISQLPTLLADPNAEFKSSPFFTEQLTAFEVWLEFGSEHKDPPAQLPIVLQVLLSQAHRLRALVLLGKFLDLGPWAVNLALCVGIFPYVLKLLQSPAGDLRHILVFIWAKILALDKSCQLDLVKENGHAYFISVLSSPQIPADQRTMSAFVLSTICNNCRPGQNACLIGNLLPICLSQLNDPDPMVRRWMILCMAKMWENFEEAKWAAIKENAHEKLCLLLTDVSPEVRASAVVALGELIGGAEGSEQRTNIELNLALTLAVITADCSPMVRKELVISLSRIVSSYESNFVQVAQEIAQEERLRAVLEAKRLEESRKSKKRASVPKISDADHLNNNSDLYGNGSQSSVYGCLWKIILNLCTDPFDQVANRAQSIVKRISSKFSMEELMSHNLINRTNFNFNNLNGSMNGLNSSGSGFLNSSNGNLGASMNGSNLNSSNNNLGGSSGGGFGLNNSNSSIRNTFVNISRITNRDPRSPTKTKLGNQRSPILTSSTNNVGTNLNGNQLNLNNNNINNGNINNNNNNNSSINNNGNNINNNGNGNNNNINNNNGLGNQLANTFQSLSLSSGLGGNKTNKMSQSISSMNSSSQSLQNDFLMVSDSMPFEEDELYSDYYEWSCNYFSKPMMQSTGEDFESFESIEKKWKRQRNEMIIQESKEAVQNIIQQPPKSFSQMTIFAEPNGQPISHLQFHPFDNILVVSDGLENISVWNYDDGQRINTFNNCNMSGTRITSMKLVNDYDPSMIITAADDGVVRIWRGYESNDTLKMVSSWRAFPEFATTGNDPIGRLVLDWKGDSGLVLVSGETPDSPKIRIWDVERELGVQDIFIGTESVVTCMANEKRGPLFSAGFSDGLVKLFDQRIPGKYSCVSTLTEHKSYIVNVSMPASLGGKTVVSGSSTGEIKFWQHSYECSSTTIHNNDVISSFSVHEYAPLIACGSQNQRIKIMNFTGEDVCTIRYHDGFLGQRIGPVSCVAFHPYNILMGAGATDSIISIYNGDSKSKSNVDW
What are the official names of this protein?
Protein raptor homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RAPTOR family.
Protein: CAS2_METRM
Sequence: MKVLVSFEIKFKTNKEKIISILKHFGFRRMQENLYFGDVEYDELYAMQSDIMENIREYDSILTIPICKSCYLKLNVFGRNLSFKDELYKIF
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: S12A3_RAT
Sequence: MAELPVTEMPGDALCSGRFTISTLLGGDEPPPAACDNSQPSHLTHGSTLYLRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDGRPGHELTDGLVEDETGANSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQENGTPIVDPINDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPASKDKASKGFYSYHGDIFVQNLVPDWRGIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDVNDTITPGPGLCEGLACGYGWNFTECSQQHSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIAPGKQRVPELRLIASGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKKNWQSAHPATLEDYIGILHDAFDFNYGVCIMRMREGLNVSEALQTHTAPEALVQEEQTSTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLHRKKRWGKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPQVEHTKRFEDMIAPFRLNDGFKDEATVAEMRRDYPWKISDEEINKNRIKSLRQVRLNEILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLETLSQDLSPPVLLIRGNQENVLTFYCQ
What is the function of this protein?
Electroneutral sodium and chloride ion cotransporter.  In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:8021284, PubMed:10894798).  Receptor for the pro-inflammatory cytokine IL18.  Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2, either independently of IL18R1, or as a complex with IL18R1 (By similarity).
What are the official names of this protein?
Solute carrier family 12 member 3, Na-Cl symporter, Thiazide-sensitive sodium-chloride cotransporter.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Protein: SYA_PETMO
Sequence: MKYFTSEEIRENFLYFFEKKGHKKLPSSSLIPNDPQLLFTVAGMVPFKPIFWGKVEPTYTRITTCQKCLRTNDIENVGRTPRHHTFFEMLGNFSFGDYFKKEAIKWAWEFLTEELGLPAEKLWASVYETDDEAFNIWKDDIKIPENKILRFGKEENWWGPAGQTGPCGPCSEIYFDTGYTENCPDQENCTPACDCGRFVEIWNIVFTEYYSDENGNLSPLPRKNIDTGAGFERICAVTQGKYDNFDSDLFKEIIEEIQRIFGVKFRVNKSKDVSIKVIADHSRAIAFLISEGIIPSNEGRGYVLRRLIRRAVRHGALLEAKGPFLSSILETVIKKMGKIYPELIEKEALIKDISFMEEEKFFETMEKGMERLNNIIQNLNNETTLPGKIAFELYDTYGFPLDLTKEILSEKGIEVDEKEFTELMNKQREMARSASGKVEYDTEKQIYKEIDKFLTPTEFIGYDKLSSTEEVQLIIKGNSIVPQAQEGDEIELFFPKTPFYAERGGQVSDKGVIYNETFEAEVIHVKPIRNEIISHLVKIKKGSIKNGERVFLKVDEKKRKATEKNHTATHLLHSALRKVIGEHIRQAGSYVAPERLRFDFTHYEPLTQDQIKQIEYLINEQIQKAIPVNIYLKSLEEAKSMDVIALFEEKYGEVVRIVEIDDFSRELCGGTHVSNTGEIGLFKILEESSISSGVRRIEAITGFESLNYATELESIMTNLSKMLDSSRDQIPDKIEGILKTIKNQEKEIKQLQFQLATKNIERLAETPQIIEGEKVVVAQLENLEKDVHANTADILLQKLGRGVVILFNKSNNEQVSLVVKVSKDTSKKFHAGNIARKIASYLGGGGGGGPTFAQAGGKYANKVKEVIEHINDFMEV
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ7_BORPE
Sequence: MSTSSSASALGRRAGPLDGLIGEIDRALRVLSGAATAARPYPAQAPEAPDALSEREKRHAAGLMRVNHVGEVCAQALYRGQAAACREPAARALLREAAAEEVDHLAWCHERLRELGSRPSLLNPFWYTGSFALGVLASYAGVPRNLGFMAETERQVEAHLDGHLRTLPVQDQRSRDIVQKMKEDEAQHRASAERAGGVPLPAPVRGAMRAMSKVMTSTAYWL
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DBP2_USTMA
Sequence: MSYGGYSGGSGRGGSYGGGRGGYGGGSSSYGNGGSSYGGGSSYGGGSSYGNGGGGYGGGYGGGYGGGDRMSNLGSNLGAVDWNSVNLVPFEKNFYVEDPRVSNRSDSEVQQYRASKQMTIQGQNVPKPVTSFDEAGFPDYILSEIKKMGFSEPSAIQSQAWPMALSGRDLVAIAETGSGKTIGFALPAMVHINAQPLLKPGDGPIALILAPTRELANQIQVECNRFGGSSRLRTCAVYGGVPKGPQIRDLQRGAEICIATPGRLIDMVDAGKTNLRRVTYLVMDEADRMLDMGFEPQIRKILQQIRPDRQTLMFSATWPKEVQRLAGDFLNNYAQVNIGSTELAANHNVKQIIEVCTEFEKKGKLIGHLETISAENGKVIIFTSTKRVADDLTKFLRQDGWPALAIHGDKQQQERDWVLAEFKSGRSPIMVATAVASRGLDVKDISYVINYDFPTNTEDYVHQIGRTGRAGRTGTAYTYFTPENSKSARELIGILREAKQEIPREIEEMGRFGGGGGGRGFRGGRGRGRGRGGYGGGGRTGANSFAVGNSRW
What is the function of this protein?
ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
What are the official names of this protein?
ATP-dependent RNA helicase DBP2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.