PharMolix/UniProtQA huggingface dataset:
Protein: SPNS2_MOUSE
Sequence: MMCLECASAAAGGAEEEEADAERRRRRRGAQPGAGGSACCGARGVGGAGVVSADEEVQTLSGSVRRVPSGLPSIPSTPGCAAAAKGPSAPQPKPASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFLSDRAKAEQQVNQLVMPPASVKV
What is the function of this protein?
Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking (PubMed:22664872, PubMed:23103166, PubMed:22406534, PubMed:23180825, PubMed:34260944).  S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system (PubMed:22664872, PubMed:23103166, PubMed:22406534, PubMed:23180825, PubMed:34260944).  Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:22664872, PubMed:22406534, PubMed:23180825, PubMed:34260944).  Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (PubMed:22406534, PubMed:34260944).  Also required for the egress of immature B-cells from the bone marrow (PubMed:22406534).  In contrast, it does not mediate S1P release from red blood cells (PubMed:23103166, PubMed:22406534).  Involved in auditory function: S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (PubMed:25356849).  In addition to export, also able to mediate S1P import (PubMed:33785361).
What are the official names of this protein?
Sphingosine-1-phosphate transporter SPNS2, Protein spinster homolog 2, Spinster homolog 2, Spns2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Protein: IF2_DEHM1
Sequence: MVEKTSKSSAKTEVAPPAKVIELGAAVSVKELADSLDTNPVEVIKALMRKGIMANINQVIEFEVAKGIVEAAGFEARLKVLKKSAAKKVSPAKEKLSNFPLRPPVVTIMGHVDHGKTRLLDAIRSTNVMEKEAGGITQHIGAYQVEIKGQKITFLDTPGHEAFTAMRARGAQATDITILVVAADDGVMPQTLEALDHAKAAGVPIILAINKMDKPEANPDRVKQQLAEAGLVVEEWGGDTLAIPTSAREKKGINELLEAVLLIAELEDLRADPNQPASGVVIEAEMDKNRGPMATVLVQSGTLKLGDTVVAGTTWGRVKAMFNDVGKRIKKAEPSTPVALLGMESVPQVGDKIIAVATEKQARDMVNENSQVTRKTNAVSLTNVYDQVSKGNIKELNIILKTDVQGSLEPIKDSLEKLSTDKIKININRSGVGNITESDVMLAMASGGLIIGFSTGIETNAQRLADAEDIDIRHYDIIYKLVEDVEKAVQGLLEPTIKEVIDGRAEVRAVFESTKKLSIAGCMVLEGKVLKNSQVRLLRGGEVIVDAPSNSLRRFKDDVKEVVAGYECGVGLKDFNDFQKSDILEFYHKEKSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS2_BURMA
Sequence: MALETFVNSEPFTFGVELEIQIVNTHNYDLTKAASDLMRLIKDAKFPGNITPEITESMIELSTGICRTHDQALGELHAIRDTLVSAADQLNVGLCGGGTHAFQQWSERQIFDAPRFQYISELYGYLAKQFTVFGQHVHIGCPDADSALFLLHSMSRFIPHFIALSASSPYVQNVDTGFHSARLNSVFAFPLSGRAPFVLTWHGFEEYFTKMVNTGVVNSMKDFYWDIRPKPGYGTIEVRVMDTPLSVDRAAAIACYIQTLARYLLIDRPLKLSEDDYLVYTFNRFEACRFGLEGTCVNPQTGERRTIAEDILDTLDRIAPHAAALGSRAALDEIGALAKARVNDASWLRTIFKQEKSLNETVRQQCLRWRE
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: LSPA_MYCLB
Sequence: MMGRVPDGPTGLAALVPSVEEAQAMLPPRRLRLLLSIAAVVLTLDIVTKVLAVKFLLPGKSVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVIGIFWMGRRLVSSWWALGLGMILGGAMGNLVDRFFRAPAPLRGHVVDFLSIGWWPVFNVADPSVVVGAILLVVLSIFGFDFDTVGRRKAEFDIAGQRKAEQR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KAT8_MOUSE
Sequence: MAAQGATAAVAATTSGTVGEGEPGPGENAAVEGPARSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKFEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
What is the function of this protein?
Histone acetyltransferase which may be involved in transcriptional activation (PubMed:31794431).  May influence the function of ATM.  As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (Probable).  As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.  That activity is less specific than the one of the MSL complex.  Can also acetylate TP53/p53 at 'Lys-120' (By similarity).
What are the official names of this protein?
Histone acetyltransferase KAT8, Lysine acetyltransferase 8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, MYST-1.
What is the protein family that this protein belongs to?
Belongs to the MYST (SAS/MOZ) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: C11AA_BACTI
Sequence: MEDSSLDTLSIVNETDFPLYNNYTEPTIAPALIAVAPIAQYLATAIGKWAAKAAFSKVLSLIFPGSQPATMEKVRTEVETLINQKLSQDRVNILNAEYRGIIEVSDVFDAYIKQPGFTPATAKGYFLNLSGAIIQRLPQFEVQTYEGVSIALFTQMCTLHLTLLKDGILAGSAWGFTQADVDSFIKLFNQKVLDYRTRLMRMYTEEFGRLCKVSLKDGLTFRNMCNLYVFPFAEAWSLMRYEGLKLQSSLSLWDYVGVSIPVNYNEWGGLVYKLLMGEVNQRLTTVKFNYSFTNEPADIPARENIRGVHPIYDPSSGLTGWIGNGRTNNFNFADNNGNEIMEVRTQTFYQNPNNEPIAPRDIINQILTAPAPADLFFKNADINVKFTQWFQSTLYGWNIKLGTQTVLSSRTGTIPPNYLAYDGYYIRAISACPRGVSLAYNHDLTTLTYNRIEYDSPTTENIIVGFAPDNTKDFYSKKSHYLSETNDSYVIPALQFAEVSDRSFLEDTPDQATDGSIKFARTFISNEAKYSIRLNTGFNTATRYKLIIRVRVPYRLPAGIRVQSQNSGNNRMLGSFTANANPEWVDFVTDAFTFNDLGITTSSTNALFSISSDSLNSGEEWYLSQLFLVKESAFTTQINPLLK
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of mosquitos.
What are the official names of this protein?
Pesticidal crystal protein Cry11Aa, 72 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryXIA(a).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: Y762_HAEIN
Sequence: MILFAGDPHGSYDHIYPFIKEQENVALIILGDLQLTTSDELDKLAKHCDIWFIHGNHDSKTISAFDSIWGSEWQSRNLHNRVVDIQGTRIAGLGGVFRGQIWMPPNRPMFFDPIHYCQYSPQEKIWRGGVPLRHRTSIFPSDIEILENQQADVLICHEAPKPHPMGFQVINDLAMKMGVKLVFHGHHHENFTYRTKYPYKITNVGFRSLADAEGNYLLQTIDDREK
What are the official names of this protein?
Uncharacterized protein HI_0762.
Protein: XYLA_BACP2
Sequence: MANSNMKTLHSLEGIGKIQFEGKQSKNPLAFKSYNPSEVIGGKTMKDHLRFSVAYWHTLTADGTDMFGTGTMQRAWDSYSGMDLAKARLEVAFQLFDLLDVPYFSFHDRDIAPEGDTLQETNQHLDIILERMKEYMRDSGVKLLWNTANMFKHPRFVHGAATSCHADVFAYAAAQVKKGIETAKELRAENYVFWGGREGYDTLLNTDMKRELDHMASFLHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDADAATSIAFLKQYGLDTHFKLNIEANHATLAGHTFEHELRVARIHGLLGSVDANQGNTLLGWDTDEFPTDLYATTLAMYEILQNGGLGTGGLNFDAKVRRASFELEDILYAHIAGMDAFAKGLRVAHRLIEDRVFEDVIKHRYRSFSEGIGRDISEGKANFHILEEYALKHPLIRNESGREEQLKARLNQYLLED
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIXB_ECOUT
Sequence: MNTFSQVWVFSDTPSRLPELMNGAQALANQINTFVLNDADGTQAIQLGANHVWKLSGKPDERMIEDYAGVMADTIRQHGADGLVLLPNTRRGKLLAAKLGYRLNAAVSNDASAVSVQDGKATVKHMVYGGLAIGEERIATPYAVLTISSGTFDAAQPDASRTGETHTVEWQAPAVAITRTATQARQSNSVDLDKARLVVSVGRGIGSKENIALAEQLCKAIGAELACSRPVAENEKWMEHERYVGISNLMLKPELYLAVGISGQIQHMVGANASQTIFAINKDKNAPIFQYADYGIVGDAVKILPALTVALAR
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixB.
What is the protein family that this protein belongs to?
Belongs to the ETF alpha-subunit/FixB family.
Protein: VU3_HHV6Z
Sequence: METTNSRRVSSAQRQILATATVRFIEGLHEPAQDSMMCGDDELQSQERMKKRQRLYNKSKRDLVDLLRVYTCLNSVRMFTFVNFGRRIPLAWPEGYELVINNCRDENEYADEKLGELADLVCCRERLVVLGYVKKRGEIGSEPAYWFLKGDIVVLLGGAGRVYAHTWLLPQQLCRVGDTIDDFLRKGLKRFYYAHQLVSSLQFVVEDTEVDGVCSCRDVLCFRDRHIGRSFALRWPKNETLLFHRRRDSFVFVRCDEARRRLAEMCFFGSFGYKYFADAGRISLYVADDGRIFGFNDNDEDGRPRFVAENFQQFRRIGVIQYYKSYVFRREQPEWALLPTCHLSRMFYQKTWRQADEDLLFVKARNDERQEFPDAGTRSAVHDVVR
What are the official names of this protein?
Protein U3.
Protein: PGK_STRS2
Sequence: MAKLTVKDVELKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYILEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVAFIAGATRGAELEAAINALEDGQVLLVENTRFEDVDGKKESKNDEELGKYWASLGDGIFVNDAFGTAHRSHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKTLLEKANGKLILPVDSKEANAFAGYTEVRDTDGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTP_ECO45
Sequence: MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLITAVVLMILGPTIWVQILGHEKAIFPYEYPALFSISVAFLGIWLFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RU2B2_ARATH
Sequence: MLTADIPPNQSIYIKHINEKIKKEELKRSLYCLFSQFGRLLDVVALKTPKLRGQAWVVFTEVTAASNAVRQMQNFPFYDKPMRIQYAKSKSDYVTKAEGSFVPKEKKMKQEEKVERKRHAEETQQPSMPNGATTQNGMPVPPFQPSGQDTMPPNNILFIHNLPIETNSMMLQLLFEQYPGFKEIRMIEAKPGIAFVEYEDDVQSSMAMQALQGFKITPQNPMVVSFAKK
What is the function of this protein?
Involved in nuclear pre-mRNA splicing.
What are the official names of this protein?
U2 small nuclear ribonucleoprotein B'' 2, U2 snRNP B'' 2.
What is the protein family that this protein belongs to?
Belongs to the RRM U1 A/B'' family.
What are the subcellular locations of this protein?
Nucleus, Cajal body. Nucleus, nucleoplasm. Cytoplasm. Note=Present in coiled bodies and an interchromatin network. Redistributed throughout the cytoplasm upon entry into mitosis.
Protein: RRAGA_MOUSE
Sequence: MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR
What is the function of this protein?
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.  Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form.  In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB.  Involved in the RCC1/Ran-GTPase pathway.  May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.
What are the official names of this protein?
Ras-related GTP-binding protein A, Rag A, RagA.
What is the protein family that this protein belongs to?
Belongs to the GTR/RAG GTP-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Lysosome.
Protein: SCNM1_BOVIN
Sequence: MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKPPGKGTEQNPRQHNELRREETTAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAPRPSVSRPPLPPPEVEPQGGKISREPEPEAGSQTKESATVSSPAPMSPTRRRALDHYLTLRSSGWIPDGRGRWIKDENVEFDSDEEEPPDLPLD
What is the function of this protein?
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.  Plays a role in the regulation of primary cilia length and Hedgehog signaling.
What are the official names of this protein?
Sodium channel modifier 1.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus speckle. Note=Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles.
Protein: GCSH_ECOSM
Sequence: MSNVPAELKYSKEHEWLRKEADGTYTVGITEHAQELLGDMVFVDLPEVGATVSAGDDCAVAESVKAASDIYAPVSGEIVAVNDALSDSPELVNSEPYAGGWIFKIKASDESELESLLDATAYEALLEDE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: ATCS_SYNE7
Sequence: MVNQQTLTLRGMGCAACAGRIEALIQALPGVQECSVNFGAEQAQVCYDPALTQVAAIQAAIEAAGYHAFPLQDPWDNEVEAQERHRRARSQRQLAQRVWVSGLIASLLVIGSLPMMLGISIPGIPMWLHHPGLQLGLTLPVLWAGRSFFINAWKAFRQNTATMDTLVAVGTGAAFLYSLAVTLFPQWLTRQGLPPDVYYEAIAVIIALLLLGRSLEERAKGQTSAAIRQLIGLQAKTARVLRQGQELTLPITEVQVEDWVRVRPGEKVPVDGEVIDGRSTVDESMVTGESLPVQKQVGDEVIGATLNKTGSLTIRATRVGRETFLAQIVQLVQQAQASKAPIQRLADQVTGWFVPAVIAIAILTFVLWFNWIGNVTLALITAVGVLIIACPCALGLATPTSIMVGTGKGAEYGILIKSAESLELAQTIQTVILDKTGTLTQGQPSVTDFLAIGDRDQQQTLLGWAASLENYSEHPLAEAIVRYGEAQGITLSTVTDFEAIPGSGVQGQVEGIWLQIGTQRWLGELGIETSALQNQWEDWEAAGKTVVGVAADGHLQAILSIADQLKPSSVAVVRSLQRLGLQVVMLTGDNRRTADAIAQAVGITQVLAEVRPDQKAAQVAQLQSRGQVVAMVGDGINDAPALAQADVGIAIGTGTDVAIAASDITLISGDLQGIVTAIQLSRATMTNIRQNLFFAFIYNVAGIPIAAGILYPLLGWLLSPMLAGAAMAFSSVSVVTNALRLRQFQPR
What is the function of this protein?
May play a role in the osmotic adaptation.
What are the official names of this protein?
Probable copper-transporting ATPase PacS.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRM1_SULIN
Sequence: MKLKEVTEGKVRIFVPDPKEYMIEGKFDPSWAPVFYNPKMTFNRDLSVIVVSLLKPKIILDALSATGIRGIRYYVESWKSEQLILNDKNSTAASLIQINVKNNGIENAKIYNKDANALLYEIKSEYIDIDPFGSPVPFILSSVNATIRNGIVAFTATDLSPLEGSSRTSCRRKYDAINYKLSSSKELGLRILIGKIIREAATLEKTVHPLFSFYADYYYRLFAIVESGARKADENINKNLKYFGECPRCGFQTFVDENCKTKCPICGENFIIIGPLYIGPLHNMEFLKRMIDTYSDFNYLSSFNRIQKLLNVIEKEAKYKSVFYNISKLASKLKVSAIPPIDSILECLGDASKTHFAPTGIRTDKGYEEIIRCVKSLR
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: RUVA_NEIG2
Sequence: MISRLTGKLVEKNPPQIVIDVNGVGYEADVSMQTFYNLPPVGESVQLFTQLIIREDAHLLFGFATAEERKTFRQLIKVGGIGAKTALGILSAMTADELARAVAEEDVKRLSSAPGIGKKTAERMVLELRGKLVAHTVTDGLFAASPAADETEDIVSTLLALGYNEREAKAAVKGVPKGTDVGEGVRLALKNLLK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: TPS7_MAIZE
Sequence: MATTGTTSMPAPVFHPTVWGDYFIKFVPEPLQVSDETMAERIRHLREEVSGMFQACKNVVDKTNLVDVVQRLGIDHHFEEQIATALASIHSAGLFNSSSLHEAALRFRLLRQQGFWVPADELVKFIKNEDGSFIDGITNDPKGLLSLYNAAHLVTHDEGTTTLEDAIAFARQHLEAARRCSLKSPLAEQVGRALGIPLPRTLKREEAIAFIPEYSSQQDQQVYSPVILELAKLDFNLLQHLHQEELKEISQWWKDLSGEIGLGYVRDRIVECYFWSYTVHYERGQARARMILAKVFMLTSLLDDTYDVHATLEEARELNKAIQRWDESDVSLLPEYLKKFFVKVISNFREFEDELESHEKYRNVYNIKGFQTLSKHYLQEAEWFHHGCTPSFKDQVNVSVITGGAQVLSIGLLVGMGHEATREAFEWAIGDTDAIWACGEVSRFMDDMSAFKNGRNKMDVASSVECYIKEHNVPSEVALARINSLVEDAWKTINQAPFKYPALFPVVQRVTSLAKSMTLLFLDKRDAYTYSKDFQTTLETHFVRHIPL
What is the function of this protein?
Sesquiterpene synthase that catalyzes the formation of a blend of sesquiterpenes and sesquiterpenoid alcohols (PubMed:27421723).  Converts farnesyl diphosphate to tau-cadinol (PubMed:27421723).
What are the official names of this protein?
Tau-cadinol synthase, Terpene synthase 7, ZmTPS7.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR_GLUOX
Sequence: MKLLHIDSSILGDSSASRHVSAAAVAQFRKKDPSVEVISLDLASDPLPHLDVEALSWLGKDLTPDVSGRPELIAGANALKDFKAADIVVIGVPMYNLSIPSQLKAWIDRIMVAGQTFRYTSGGGIEGLAKGKKVVLAVARGGLYGEGSPAASFEHQLSYLKSVFAMIGITDLTVIEAEGLATNGGADRARILSDAEQKASAL
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RL36_GEOSM
Sequence: MKVRASVKKICVKCKIVKRKGIVRVICETPKHSQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: TPIS_METTH
Sequence: MLEDLELKDTPIVILNFKTYLESTGERALELASICGDVADETGVNMAVAPQHMDLHRVSDAVEIPVLAQHIDAVDAGGHTGSILAECARDAGAAGTLINHSEKRMQLADIEWVISRMKELEMMSVVCTNNVMTTAAAAALGPDFVAVEPPELIGSGIPVSRAEPEVITGSVDAVKKVNPEVSVLCGAGISTGDDMKAAVDLGAEGVLLASGIILADSPRDALLDLVSKV
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED10_ASHGO
Sequence: MDQQDLNKLQTNLSDAEIRLASIIESFIELGVSVYDFPGTQESTQGMVTNLKRNVERIKLLNQHANDPDSQLRNMNIPLEVLQYIEDGRNPDVYTREFVEAIRRSNQYQRAKMHALKKLRDSLAEKIGEEFPDLVPQVQGIIERANGSRDK
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 10, Mediator complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL9_LATSS
Sequence: MKVIFLEDVRGKGKKGQVKDVPDGYAQNFLIKNGKAKPATTAAVSALKGQQHAEAKNAAAELAEAKVLKTKIEDDKTIVEVKSKAGEDSRLFGSIPSKQIAQALEQQYKIKVDKRKIDLPEPIKALGYRNVDVRIHPDVTATIRVHIVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: TRPD_BORPA
Sequence: MTIAAAEALTRCIEHREIFHDEMLHLMRLLMRGELSPQIASALLMGLRVKKETVGEITAAAQVMREFATPVVTPNPQDLLDMCGTGGDGSHTFNISTTAMFVAAAAGVPIAKHGNRSASSSSGSADVLEALGANLQLTPEEVAECVAATGIGFMFAPAHHGAMKNVAAVRKELGVRTIFNILGPLTNPAGAANQLMGVFHPDLVGIQVRVLERLGSRHVLVVHGKDGMDEASLGAATMVGELKDGVVREYEIHPEDYGLSMMSNRGIKVSNREESRALVIEALDNVDGVARDIVALNAGLAIYAGNKADSIPEALALAFETISNGSARAKLEEFCAYTRKFQK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RLMN_FRATO
Sequence: MQQDKVNLLGLNQKAIEDFFISIGKKKFHARQVFKWIHKKGVIDFDAMTDLGKNLRHKLKDKAQITIPKVVFSKASKDGTHKWLIDVGGSAVETVFIPEEGRGTLCVSSQIGCTLNCSFCSTGKQGFNRNLSAAEVIAQLWIAARTLSKTDGEHDFTVTNIVMMGMGEPLMNFENVVPAMDIMMDDLAYGLSRRKVTLSTSGVVPRIYDLLEQSGVSLAVSLHTPNDMLRNEIVPINKKYNIDELLEACKLYAQKGPHKHITFEYTLMEEVNDNLSDAEELVALLKSREVPAKINLIPFNPYPGTPYKKPSNNRIHRFKEFLQHNGFVTTVRKTRGDDIDAACGQLAGDVMDKTNRKQRYLKKLGDTNAN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.