PharMolix/UniProtQA huggingface dataset:
Protein: HEMA_INCHY
Sequence: EKIKICLQKQVNSSFSLHNGFGGNLYATEEKRMFELVKPKAGASVLNQSTWIGFGDSRTDKSNPNFPRSADVSVKTANKFRSLTGGSLMLSMFGPPGKVDYLYQGCGKHKVFYEGVNWSPHAAIDCYRKNWTDIKLNFQKNIYELASQSHCMSLVNALDKTIPLQATAGVAGNCNNSFLKNPALYTQKVTPPXXKCGKENLAFFTLPTQFGTYECRLHLVASCYFIYDSKEVYNKRGCDNYFQVIYDSSGKVVGGLDNRVSPYTGNSGDTPTMQCDMIQLKPGRYSVRSSPRFLLMPERSYCFDMKEKGPVTAVQSIWGKDRKSDYAVDQACLSTPGCMLIQKQKPYTGEADDHHGDQEMRELLSGLDYEARCISQSGWVNETSPFTEEYLLPPKFGRCPLAAKEESIPKIPDGLLIPTSGTDTTVTKPKSRIFGIDDLIIGLFFVAIVEAGIGGYLLGSRKESGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEISPGCWIIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQSDPFYWGSSLGLAITAAISLAALVISGIAICRTK
What is the function of this protein?
Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.  Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase.  This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell (By similarity).
What are the official names of this protein?
Hemagglutinin-esterase-fusion glycoprotein, HEF.
What is the protein family that this protein belongs to?
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: FGF1_PIG
Sequence: MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTSGLLYGSQTPSEECLFLERLEENHYNTYTSKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPV
What is the function of this protein?
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration.  Functions as potent mitogen in vitro.  Acts as a ligand for FGFR1 and integrins.  Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades.  Binds to integrin ITGAV:ITGB3.  Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling.  Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1.  Can induce angiogenesis.
What are the official names of this protein?
Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 (By similarity).
Protein: SYGB_YERPN
Sequence: MTQQTFLVEIGTEELPPKALRSLAESFAANFTAELDNANLSHGEVSWYAAPRRLAVKVANLSAAQADREVEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLVTDKGEWLLYRAHVKGQPAQLLLAGMVNTALSKLPIPKLMRWGDKETQFVRPVHTVTLLLGTEVIPGTVLGINSDRVIRGHRFMGEAEFTIDSADQYPQILLERGKVIADYELRKSIIKRDAEQAAQQIGGVADLSESLLEEVASLVEWPVVLTAKFEEKFLAVPAEALVYTMKGDQKYFPVYDTAGHLMPHFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFKTDRKKRLEDNLPRLETVLFQQQLGTLRDKTDRIQALAGWVAAQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLSLDLQTLTEEAVRLYGSKLTNAKVVDDVIEFMLGRFRAWYQDEGHSVDTIQAVLARRPTKPADFDARVKAVTYFRTLDAAAALAAANKRVSNILAKSTDTLNDHVHASILKEPAELKLATHLVVLRDQLEPVFAAGQYKEALVELAALRETVDEFFESVMVMAEDDAVRVNRLTLLSKLRELFLQVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEPA_ECO5E
Sequence: MNKTAIALLALLASSVSLAATPWQKITQPVPGSAQSIGSFSNGCIVGADTLPIQSEHYQVMRTDQRRYFGHPDLVMFIQRLSSQVSNLGMGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRRTSAQLLRPQALDLVSRDGKHVVSTLWKPEIFSLIKLAAQDKDVTRIFVNPAIKQQLCLDAGTDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPPGDGCGAELQSWFEPPKPGTTKPEKKTPPPLPPSCQALLDEHVI
What is the function of this protein?
Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands.  Likely plays a role in the removal of murein from the sacculus.
What are the official names of this protein?
Penicillin-insensitive murein endopeptidase, D-alanyl-D-alanine-endopeptidase, DD-endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M74 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: AMT2_CAEEL
Sequence: MNTLQNLTLKMDRQPTIRMKPDKQLDCSLSQDDGVWMMASSFIIFTMTAGFGLLESGRVSSKDEVNCMVKNVFDVIFGGLAYWMFGYGLTFGDSKHQLGRYVGFGDFFFDPERVSDDDSTDEKGISYSLFIFQMSFATTTSTIVSAGMSERIHLKSHCFISFFITLVHSVAGHWVWDQEGVFRMMGVVDSAGCSAVHLVGGVSGLVATLYLKPRRNRFAKNGIRTVSDPTKAILGFLMIWWGWLAFNTSSNYAVTHGQWTEGMRSAVGTILASAGGGVVTVIITRLSTKKIQMDMLIDGMLASLVASTGGCLYFTPWQATLVGAIGSSLALAAYPVTEWLKIDDPVGVFPVHVVGSIWGMIAPAIFVYRRPMNFGPPECDFQTSDEINGLLYGGGFYLLFLQSFVILVIGTYSAICAFIILFLIHHSPVGLRVDKYTEELGADLIEHGLAGFNVMTYTIEKKLDTKTLSAVLMIIVRWRAKAKLGAQRRKKIHDSGSVAPQQAESVEMNVIHRRH
What is the function of this protein?
Involved in the uptake of ammonia (Probable).  Implicated in aging.
What are the official names of this protein?
Putative ammonium transporter 2.
What is the protein family that this protein belongs to?
Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y3987_ALISL
Sequence: MRIQVDTHTYASGHAYSTISENAFSASTLGLPMFCTTDHASSMPGAPHYWFFSNQRVLPRFLHGVAILRGCEVNICNLEGDIDIPLSVDQNLDWIIASFHEPVFPPKNKLVHTQALIKIISSGRVDALGHLGNPNFDFDFKEVIQEAVKHNVAIEINNTSLKGTSRVGSVDRCYEIAKIAKELGAYITTGSDAHFCQDIGKFEKVEQLIDALDFPFDKIITHSPKQFLAFLALRGHAPIAEFEALSK
What are the official names of this protein?
Probable phosphatase VSAL_II0887.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: LGT_SALTY
Sequence: MTSSYLHFPDFDPVIFSIGPVALHWYGLMYLVGFVFAMWLAVRRANRPGSGWTKNEVENLLYAGFLGVFLGGRIGYVLFYNFPLFLDNPLYLFRVWDGGMSFHGGLIGVILVMIIFARRTKRSFFQVSDFIAPLIPFGLGAGRLGNFINGELWGRVDPDFRFAMLFPGSRAEDIALLPSHPQWQPIFDTYGVLPRHPSQLYELALEGVVLFIILNLFIRKPRPMGAVSGLFLIGYGAFRIIVEFFRQPDAQFTGAWVQYISMGQILSIPMIIAGAIMMVWAYRRRPQQHVS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TFRA_METTM
Sequence: MESELYECDVLIIGSGGAGCRAAIEVSEHKLTPIIVSKGLSFKSGCTGMAEGGYNAAFACVDPEDSPDVHFEDTMRGGGFINDPRLVRILVDEAPDRLRDLEEYGALFDRQESGLLDQRPFGGQTYRRTCYHGDRTGHEMITALKEEVIRRDIETIDEVMITSLLVEDGSVLGAMGVSIMNSEPVAFRASSTILASGGAGHIYPVTSNTMQKGGDGFAIAWKAGADLIDMEQVQFHPTGMVYPESRRGVLVTEAVRGEGGILLNSEGERFMGRYDPRGELATRDVVARAIYTEIMEGRGTENGGVYLDVSHLPDEVIEEKLETMLLQFLDVGVDIRSEPMEVAPTAHHFMGGVRIDEWGRTNLKNLFAAGEVSGGVHGANRLGGNALADTQVFGRRAGISAAKNAMSSSRRHVRSLIEEEEQRIKDMVRDGSIRPAEIRDELHEAMWSDVAIVRSRRSLESAMSRISTLMDKLGDLDVPETGGFNSNLLEALELENMLITASLVTRSALIREESRGSHYREDFPETRPEWKRSILLNRKMEPQFIGR
What is the function of this protein?
Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H).  In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen.  The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase.  The enzyme is very sensitive to oxygen.
What are the official names of this protein?
Fumarate reductase (CoM/CoB) subunit A, Thiol:fumarate reductase subunit A.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_BRUSU
Sequence: MTDLRHYDVIVSPVITEKSTMVSEHNQVVFNVARKATKPEIKAAVEALFGVKVTAVNTAVRKGKVKRFRGLVGRQSDVKKAIVTLAEGQSIDVSTGL
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RNY_MOOTA
Sequence: MLIAFLVGGAGGYAIRKYLAEAKIASAEKAAATIIEEAKKEAEARKREAVLEAKDEVHRMRNEVERESRERRNELQRLERRLLQKEETLERKSETLERKEASLHRQEEAIQRTREEVEKIRQQQVSELERISGLTTEAARNILLKNVEEEIRHETAMLIKQVEAEAKEEAEKRAREIITYAIQHCAADYVAEATVSVVNLPNDEMKGRIIGREGRNIRALETLTGVDLIIDDTPEAVILSCFDPIRREIARIALEKLIADGRIHPARIEEMVEKARRELDTKIREEGEQATFEVGIHGLHPELVRLLGKLKYRTSYGQNVLKHSLEVAFLAGAMAAELGVDVLVAKRAGLLHDIGKAVDFEVEGPHVNLGVELAKKYRESPEVIHAIEAHHGDVEPKSIEAGLVQAADAISAARPGARRETLEAYIKRLEKLEEIANSFSGVEKSYAIQAGREVRILVKPDKIDDAMAVRLARDIVKTIEQTMEYPGQIKVVVIRETRAVDYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
Protein: RUVB_PARDP
Sequence: MSQPDPMLRPEPLESDGEDRALRPQRLEDFVGQAEARANLRVFIESARMRGKAMDHTLFHGPPGLGKTTLAQIMARELGVNFKMTSGPVLARAGDLAAILTNLEARDVLFIDEIHRMNPAVEEILYPAMEDFELDLVIGEGPAARTVRIELQPFTLVGATTRLGLLTTPLRDRFGIPTRLQFYTIEELDLIVTRGARLMGIPSEPEGTREIARRARGTPRIAGRLLRRVVDFALVEGDGRLTRKIADSALTRLGVDHLGLDTADRRYLTLMAEHYGGGPVGVETLSAALSESRDSIEEVIEPYLMQQGLVSRTPRGRMLARLGWRHLGLDAPRTQESLFDE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CT121_CONLI
Sequence: MRCVPVFIILLLLSPSAPSVDAHPKTKDDVPLASFHDDAKRTLQRLWIKALCCYGYRFCCPNFR
What are the official names of this protein?
Conotoxin LiC121.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: QOX4_STAAR
Sequence: MSTIMKHTVGFIASIVLTLLAVYVTLYTSLTFHAKLTIIFGFAFIQAGLQLLMFMHLTEGKDGRLQTFKVIFALVITLCFVVGTYWVMQGGHSSHL
What is the function of this protein?
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
What are the official names of this protein?
Probable quinol oxidase subunit 4, Quinol oxidase polypeptide IV.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase bacterial subunit 4 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS4_ECO8A
Sequence: MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTR_SALTI
Sequence: MGRRAGTPTTKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLTPEGEKLAQESRERHQIVENFLLVLGVSPEIARRDAEGMEHHVSQETLDAFLAFTQQHGTSAE
What is the function of this protein?
In the presence of manganese, represses expression of mntH and mntS.  Up-regulates expression of mntP (By similarity).
What are the official names of this protein?
Transcriptional regulator MntR, Manganese transport regulator.
What is the protein family that this protein belongs to?
Belongs to the DtxR/MntR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ULAG_SHIFL
Sequence: MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCGTGKQSHGNPLMKQGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPKTCVDLWIGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPDGMDDRAVNYLFKTPGGSLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADMLRMGEALNAKVVIPFHHDIWSNFQADPQEIRVLWEIKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL
What is the function of this protein?
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P.  Is essential for L-ascorbate utilization under anaerobic conditions.
What are the official names of this protein?
Probable L-ascorbate-6-phosphate lactonase UlaG, L-ascorbate utilization protein G.
What is the protein family that this protein belongs to?
Belongs to the UlaG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_TREPA
Sequence: MLLIDVGNSHVVFGIQGENGGRVCVRELFRLAPDARKTQDEYSLLIHALCERAGVGRASLRDAFISSVVPVLTKTIADAVAQISGVQPVVFGPWAYEHLPVRIPEPVRAEIGTDLVANAVAAYVHFRSACVVVDCGTALTFTAVDGTGLIQGVAIAPGLRTAVQSLHTGTAQLPLVPLALPDSVLGKDTTHAVQAGVVRGTLFVIRAMIAQCQKELGCRCAAVITGGLSRLFSSEVDFPPIDAQLTLSGLAHIARLVPTSLLPPATVSGSSGN
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_ACTPJ
Sequence: MSIKDEKIAVLFGGVSQEREVSLNSGAAVTEALKSLGYNVEGIDTKDFPIEKLKEKGIQRVFNILHGGIGENGVLQGALEQMGIPYTGCGVMASAVTLDKFRTKLMWQAVGLPTADMVVVRRGEAVDSEQIIAKLGLPVFVKPSSEGSSVGVTKVKTVEQLLPAVEEALKFDSIVLVEAFLAGKEYSVPVLDGQVLPAVQIIPEGEFYDYHAKYISDNTQYLVPALSDDRQAEVAELVKAAYEVVGCRGWSRIDVMEDANGHFNLVEVNTCPGMTSHSIFPKSAATVGIPFEKLVERVLELSA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPIC_SALT1
Sequence: MSEEGFMLAVLKGIPLIQDIRAEGNSRSWIMTIDGHPARGEIFSEAFSISLFLNDLESLPKPCLAYVTLLLAAHPDVHDYAIQLTADGGWLNGYYTTSSSSELIAIEIEKHLALTCILKNVIRNHHKLYSGGV
What is the function of this protein?
Virulence protein that plays a central role in mammalian macrophage infection, by inhibiting phagosome-lysosome fusion and cellular trafficking, including trafficking of organelles that are devoid of Salmonella.  May act by disrupting the function of the mammalian HOOK3 protein, a protein involved in the cellular traffic.  Also required for actin ADP-ribosylase SpvB activity.
What are the official names of this protein?
Salmonella pathogenicity island 2 protein C, Secretion system apparatus protein B.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Translocated into the cytosol of macrophages via the Salmonella pathogenicity island 2 (SPI-2) type III secretion system that functions intracellularly to translocate proteins across the phagosomal membrane. Cytoplasmic in infected macrophages.
Protein: BRR1_YEAST
Sequence: MKRGESQAPDAIFGQSRAFALSDSSVNPDVIEYLKSVRQEALRTNAISIKNHMNLQKRTRHKSSMYDDEDEGALKRHAISPSLIRLQRNVEIWVRWFNSVKATVLTNAYEFTGYEDETLDLLLLFLKNYLEDMPSKCTTVEKIISVLNQHSFPEKAEEKEENLQIDEEWAKNILVRLEKTKIDSVEDVKKVITEGDKHELVGYNQWFQYLINNEPQHTTFHEKITSKQLWVLIKYMSNTWIKEIHKKGRHYRRLQDWLFYILVHTPERVTAEYTSILRDLGKKCLELIQKKPVEAHENKITLPKEMAELNVEIPAAVENMTITELTVSVIAVNYGQKDLIE
What is the function of this protein?
Involved in mRNA splicing.  Required for snRNA accumulation and manufacture of snRNPs.
What are the official names of this protein?
Pre-mRNA-splicing factor BRR1, Bad response to refrigeration protein 1.
What is the protein family that this protein belongs to?
Belongs to the BRR1 family.
Protein: AZOR2_BACSU
Sequence: MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDLYKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPLWNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEMEMGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines (PubMed:17284825).  Can reduce methyl red (PubMed:17284825).
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 2, Azo-dye reductase 2, FMN-dependent NADH-azo compound oxidoreductase 2, FMN-dependent NADH-azoreductase 2.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: ERYH_BRUA2
Sequence: MTKFWIGTSWKMNKTLAEARLFAEALKAADAGRSPDIQRFVIPPFTAVREVKEILSGTSVKVGAQNMHWADQGAWTGEISPLMLKDCNLDIVELGHSERREHFGETNETVGLKVEAAVRHGLIPLICIGETLEDRESGRAAAVLEEEVRGALSKLSEAQKQAEILFAYEPVWAIGENGIPASADYADARQAEIIAVAQSVLARRVPCLYGGSVNPGNCEELIACPHIDGLFIGRSAWNVEGYLDILARCATKVQAN
What is the function of this protein?
Catalyzes the isomerization of D-erythrulose-4P to L-erythrulose-1P.  Involved in the degradation pathway of erythritol, that allows B. abortus to grow on this compound as the sole carbon source.
What are the official names of this protein?
L-erythrulose-1-phosphate isomerase, D-3-tetrulose-4-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_CLAM3
Sequence: MAGKSSGDRRKPLRGAKGGKNAAPAKSIRVGVIDYKDVATLRKFISERGKIRARRITGVSVQEQRLIARAVKNAREMALLPYAGSGR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RL31_METSB
Sequence: MKADIHPQYHLVKVVMTDGTEFLTRSTYGSEGATLNLDIDPKTHPAWTGGSAQLLDRGGRLSRFNSRFSGLSFGKK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: NA1C_ANTEL
Sequence: GVPCLCDSDGPSVRGNTLSGILWLAGCPSGWHNCKAHGPTIGWCCKQ
What is the function of this protein?
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction.  It strongly stimulates mammalian cardiac muscle contraction.  Paralyzes the shore crab (C. maenas) by tetanic contractions after intramuscular injection.
What are the official names of this protein?
Delta-actitoxin-Ael1a, Delta-AITX-Ael1a, APE 2-1, Anthopleurin-C, AP-C, ApC.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ENO_ONYPE
Sequence: MPYIESILAREVLDSRGNPTVEVEVYTESGAFGRAIVPSGASTGQYEAVELRDGDAQRFLGKGVLQAVKNVIEVIQPELEGYSVLEQTLIDKLLIKLDGTPNKSNLGANAILGVSLACAKAAANYLNLEFYQYVGGVLPKQMPVPMMNVINGGAHASNSVDFQEFMILPTGPTSFKEALRYGAEVFHHLGKILKQKGLPTTVGDEGGYAPDLNSNEEALQIILEAIKSAGYEPGKDIFLGMDVAASEFYDKKLQKYVLASENNKAFSSQELVHYYETLVSKYPIISIEDGLDENDWDGWKYLTQKLGNQIQLVGDDLFVTNTQKLAQGIENKIGNSILIKLNQIGTLTETLETIEMAKKASYTAVISHRSGETEDTTIADLAVATNAGQIKTGSCSRTDRMAKYNQLLRIEDQLVEAPFLGLKTFYNLKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: BGL37_ARATH
Sequence: MQHNTYIYILTMKLLGFALAILLVVATCKPEEEITCEENVPFTCSQTDRFNKQDFESDFIFGVASSAYQIEGGRGRGLNVWDGFTHRYPEKGGADLGNGDTTCDSYRTWQKDLDVMEELGVKGYRFSFAWSRILPKGKRSRGINEDGINYYSGLIDGLIARNITPFVTLFHWDLPQSLQDEYEGFLDRTIIDDFKDYADLCFERFGDRVKHWITINQLFTVPTRGYALGTDAPGRCSQWVDKRCYGGDSSTEPYIVAHNQLLAHATVVDLYRTRYKYQGGKIGPVMITRWFLPYDDTLESKQATWRAKEFFLGWFMEPLTKGKYPYIMRKLVGNRLPKFNSTEARLLKGSYDFLGLNYYVTQYAHALDPSPPEKLTAMTDSLANLTSLDANGQPPGPPFSKGSYYHPRGMLNVMEHFKTKYGDPLIYVTENGFSTSGGPIPFTEAFHDYNRIDYLCSHLCFLRKAIKEKRVNVKGYFVWSLGDNYEFCNGYTVRFGLSYVDFNNVTADRDLKASGLWYQSFLRDTTKNQDILRSSLPFKNGDRKSLT
What is the function of this protein?
May degrade glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.  These toxic degradation products can deter insect herbivores.  Seems to function in abscisic acid (ABA) and methyl jasmonate (MeJA) signaling in guard cells.  Functionally redundant with TGG1.
What are the official names of this protein?
Myrosinase 2, Beta-glucosidase 37, AtBGLU37, Sinigrinase 2, Thioglucosidase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.