PharMolix/UniProtQA huggingface dataset:
Protein: EIF3A_DICDI
Sequence: MSTQQALAQANEHALSQANDLIKVGSKLRALSVLRDLLSDRSQWHSSLEQIMSLYVSLCAEQLDYQSLRDGIHHFKVSIMSQKEFSIVPLENIFKEIITPIEQKVDELKEKIEKENQENPLVEQNEISLIDPQQTLLFSYMKYLFEAYKAMIEVLTRQNTKFEHTKFDHSKFDSTLLKISTQALNYCSKYQRKPDFMVLTELFRSSIEQLFKVPSLDTVNTHIEIRFHQLTVAISLGLYLIAYKSIEDINIMLFSLLVKPKPVVLATYYQKLAQVYWITNAHLLHAYALYKHYVYNKNYNMNFTQADSQLYSSVLLVAALSSPIQEVNQNQSLLQFDSQSQRAMGLASLLSLQSIPKRETFLVDVRKVTNEVYPELADLASIFEKKTSPLMFAKLLEPKIKFIEGHAQLSQYLKPFLRVVFTKIALQVSKVYEVIKIEEFIKLVPFYTKTQIELYLLESIKRKLIGARIDHKNGVIRFGHYDFDSAKISDQLSNLATGVGKALNMIEPEKKQQQHDKLKKEVYVKIINSLQDEHRRILARKEIIEKKKIYMEQQDRIKKQKEHEELQKKIQEKVARDQQRLKEDMERREKEQAEEESQQNQLDQTINAIDKAKVEMKAKIAKIAKQLYILERAYREEELPVVESLQKTKAVEDKQYFESTQAEFLKLHREVHDRNVTEKARLNRIVPEYQKFTQAVIEERKKQLPALQKEQEKRFQEFLIQQEQDVQERKAKREKARIAAAQEKARKEEQERERLEQEHLEQERLEEERKNAPYVPPSSRRTFRDDDDEREESGRWGGRRGGDDFGRSKADEGDRWGRREDAPPPRRDEGGDRWGRREDAPPPRRDEGGDRWGKREDAPPPRRDEGGWGRRDDAPPPRRDEGGDRWGRRDDAPPRRDDAPPPRRDDAPPPRRDEGGDRWGRRDDAPPRRDGGGSGGFGGRRDDAPPRRDEGGDRWGRREDAPPPRRDEGGDRWGRRDDAPPRRDGGGGSGFGRNQGAQGDQNDSWRSDNKKEENKKDADGWQTVGAKKRY
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit A, eIF3a, Eukaryotic translation initiation factor 3 subunit 10.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPOL_HBVA4
Sequence: MPLSYQHFRKLLLLDDGTEAGPLEEELPRLADADLNRRVAEDLNLGNLNVSIPWTHKVGNFTGLYSSTAPIFNPEWQTPSFPKIHLQEDIINRCQQFVGPLTVNEKRRLKLIMPARFYPTHTKYLPLDKGIKPYYPDQVVNHYFQTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELQHGRLVIKTSQRHGDESFCSQPSGILSRSSVGPCIRSQLKQSRLGLQPHQGPLASSQPGRSGSIRARVHPSTRRCFGVEPSGSGHVDPSVNNSSSCLRQSAVRKAAYSHLSTSKRQSSSGHAVEFHCLPPSSARPQSQGSVFSCWWLQFRNSKPCSEYCLSHLVNLREDRGPCDEHGEHHIRIPRTPARVTGGVFLVDKNPHNTAESRLVVDFSQFSRGITRVSWPKFAIPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLLIGSSGLSRYVARLSSNSRINNNQYGTMQNLHDSCSRQLYVSLMLLYKTYGWKLHLYSHPIVLGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHREFLYTAVTNFLLSLGIHLNPNKTKRWGYSLNFMGYVIGSWGTLPQDHIVQKIKHCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQYMNLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGLSRPLLRLPFQPTTGRTSLYAVSPSVPSHLPVRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: CRYM_MACFL
Sequence: MSWSPAFLRSEDVERYLGSSSILLPALEKALANFSSGSEGGVVQPVRTVIPVAKHQGFLGIMPVYSASEDALTTKLVTFYEGMSPTSTAPSHQTTVLFFDPSNGSLLSIMDGNIITAKRTAAVSAIATKFLKPPSSEVLCILGAGVQAYSHYEIFKEQFSFKEVRIWNRTKKNAEKFAQTVKGDVRVCSSVQEAVTGADVIITVTMATKPILFGEWVKPGAHINAVGASRPDWRELDDEIMKNCVLYVDSREAALKESGDVILSGAEIFAELGEVVKGVKPAHREKTTVFKSLGMAVEDAVAAKLVYDSWSSGK
What is the function of this protein?
Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK).  Binds thyroid hormone which is a strong reversible inhibitor.  Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity).  Major component of eye lens in marsupials.
What are the official names of this protein?
Ketimine reductase mu-crystallin, CDK108, NADP-regulated thyroid-hormone-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ornithine cyclodeaminase/mu-crystallin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C75A7_EUSER
Sequence: MAVGNGVLLHIAASLMLFFHVQKLVQYLWMNSRRHRLPPGPIGWPVLGALRLLGTMPHVALANMAKKYGPVMYLKVGSCGLAVASTPEAAKAFLKTLDMNFSNRPPNAGATHLAYNAQDMVFADYGPRWKLLRKLSNIHILGGKALQGWEEVRKKELGYMLYAMAESGRHGQPVVVSEMLTYAMANMLGQVMLSKRVFGSQGSESNEFKDMVVELMTVAGYFNIGDFIPSIAWMDLQGIQGGMKRLHKKFDALLTRLLEEHTASAHERKGSPDFLDFVVANGDNSEGERLQTVNIKALLLNMFTAGTDTSSSVIEWALAELLKNPIILRRAQEEMDGVIGRDRRFLEADISKLPYLQAICKEAFRKHPSTPLNLPRIASQACEVNGHYIPKGTRLSVNIWAIGRDPSVWENPNEFNPDRFLERKNAKIDPRGNDFELIPFGAGRRICAGTRLGILLVEYILGTLVHSFVWELPSSVIELNMDESFGLALQKAVPLAAMVTPRLPLHIYSP
What is the function of this protein?
Catalyzes the 3'5'-hydroxylation of naringenin and eriodictyol to form 5,7,3,'4',5'-pentahydroxyflavanone and 3',5'-hydroxylation of dihydrokaempferol and dihydroquercetin to form dihydromyricetin.
What are the official names of this protein?
Flavonoid 3',5'-hydroxylase, F3'5'H, Cytochrome P450 75A7.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: FSP1_XENLA
Sequence: MGSKVSVEESVRVVIVGGGFAGIAAASQLKSFGIPFLLVDMKDAFHHNVAALRACVESGFARKTFISYKDSFHDSFKQGKVVGINLQTQLVILESNEELSFSHLIIATGSNGPFPGKFNEVISKDQAIQIYENLVEEIQKAKHVVVVGGGSAGVEMAAEVKTDYPEKEVTLIHSKIALADVQLQPSVRRTVKEILLRKGVRLILAQKVTNLDQVTPNVAQENMELQLDKDSEVVNCDLVLCCIGLKVSSSSYRSALGDKMAEDGSLIVNDYLQVQGHENVYAVGDCAYINEPKMAYYAGIHARVAATNVRNSLIGKSLKSYIPGALSMLLSMGRNDGVGQFNGYYLGRCFVTMAKSRDIFVSKSWKEMGQTMPR
What is the function of this protein?
A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis.  At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis.  Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis.  This anti-ferroptotic function is independent of cellular glutathione levels.  Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms.  Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis.  May play a role in mitochondrial stress signaling.  Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death.
What are the official names of this protein?
Ferroptosis suppressor protein 1, FSP1, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, AMID, p53-responsive gene 3 protein.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Lipid droplet. Cell membrane; Lipid-anchor. Cytoplasm. Mitochondrion membrane. Nucleus.
Protein: RL331_STRPB
Sequence: MRVKINLECSECGSNNYLTSKNKSSHPEKIKVPKYCPKERKVTLHVET
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: NDHI_ANGEV
Sequence: MFAMVNGLRSYSQQAIQAARYIGQGFVVTLDHMNRLPMTIQYPYEKLIPSERFRGRIHFEFDKCIACEVCVRVCPINLPVVDWELKESVRKKQLKNYSIDFAVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYDQIALGRLPVSVVQDPTTQTVSGLNYLSKGVMEGHPDSRSVTNF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RBSU_STAAW
Sequence: MSIVALLIGLGPLIGWGFFPTVASKFGGKPVHQIIGATVGTLIFAIILAVVTSSGFPTGTNLLFALLSGAGWGFGQIITFKAFELVGSSRAMPVTTAFQLLGASLWGVFALGNWPGIGHKIIGFTALVVILIGARMTVWSERKEASNAKNLRRAVVLLLIGEFGYWLYSAAPQATSIDGLTAFLPQAMGMVIVAVIYGFMNMKAENPFRNKITWLQIISGFFFAFGALTYLISAQPNMNGLATGFILSQTSVVLATLTGIYFLKQHKTSKEMVITIIGLVLILVAASVTVFIK
What is the function of this protein?
Could be involved in the uptake of ribose.
What are the official names of this protein?
Putative ribose uptake protein RbsU.
What is the protein family that this protein belongs to?
Belongs to the GRP transporter (TC 2.A.7.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AIM9_YEAST
Sequence: MIRYTVAGHSRRCVVGASKRVGAIKCITVAATKRFISNKPNEVFTKLTNDNDPKRDAFFKYTWGSWLKNDKQEKEKRFTKFSIEGLNRILNDIYIQSNEMAKAPDGKILPPVFNKNLTVSLVNNVVPKNIGKINPNEKVQVTTLSSIHEGKHHRIYKVDTNLNKAFILRIPYPLENENTLSYRIRSEVATMDFADLKLGIKVPKIFCYGVNSLNPVRQPFVLQEFIEGELLMKDWDPLIEDGSSNQKKYDNVIKQVSDFQSKLVSLKLNAFGSIYFNNDLKDGNEKEFVKEDIYDGETNPDLQNRWKIGPSVERCLWRHKSHLDFHKQMKPFLGPWPKKSPMDIIKNTGLLEAENAKTRIAMKEAGSSAELMYPRTLKEQITTYENLAKIAPDLFNVKTKAIPNMQELLSPRLFHPDLDPMNIIVNKEAQEAYLLDFEGACTKPFILQNSPQFIAYDGPKIYDLKEDITDFDKLSEAEKVQYQFMYKRTRNQHQWEKKLNDNNPKLITAVAPPVKLLRSPYIAAVERKTEEEYLLIDESLLQLKEVWDIFAQNELVNQKKFPLNYSKEDIERHVEDLQKLHEKLISTPFAATQGWIPQDMFDQLLNSGSIVKQENGDYTVKQPEATK
What are the official names of this protein?
Altered inheritance of mitochondria protein 9, mitochondrial, Found in mitochondrial proteome protein 29.
What is the protein family that this protein belongs to?
Belongs to the AIM9 family.
Protein: ARNT_ECO5E
Sequence: MKSVRYLIGLFAFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWIVPHLLGLRYFEKPIAGYWINSIGQWLFGANNFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTWKGKSAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLTIAQREPDFWHYFFWVEHIQRFALDDAQHRAPFWYYVPVIIAGSLPWLGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILSCFAPLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATFVVSPWGPMNTPVWQTFESYKVFCAWSIFSLWAFFGWYTLTNVEKTWSFAALCPLGLALLVGFSIPDRVMEGKHPQFFVEMTQESLQPSRYILTDSVGVAAGLAWSLQRDDIIMYRQTGELKYGLNYPDAKGRFVSGDEFANWLNQHRQEGIITLVLSVDRDEDINSLAIPPADAIDRQERLVLIQYRPK
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VAC14_HUMAN
Sequence: MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQEGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEVRGPFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHALNTILLTSTELFQLRNQLKDLKTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLAEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDSLKAAPKSQKADSPSIDYAELLQHFEKVQNKHLEVRHQRSGRGDHLDRRVVL
What is the function of this protein?
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Pentamerizes into a star-shaped structure and nucleates the assembly of the complex.  The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764).  Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
What are the official names of this protein?
Protein VAC14 homolog, Tax1-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the VAC14 family.
What are the subcellular locations of this protein?
Endosome membrane. Microsome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
Protein: FMT_BORAP
Sequence: MKIFFVSSSSIALEVFKEIVKHYEVVGVLTLPDKPKGRGQKLSQNVIKLEAIAKNIKVFDPLILDDNILNLIRDLNPDLMLVFSYGKIFKKEFLDIFPKGCINVHPSLLPKYRGVSPIQSAILNGDCVSGITIQNMALKMDSGNILVQKNFKIKSCDTSYDISKLVSSLSPNLVLEALEKIGKGFLGIPQKSSEATFCSFFKKESGFVDFNLSAFEIKNRINACNPWPLARARLDYGDIIFHRADFLKIDLYKEKKVGEIVDFDSEKGLFVNTGEGILLLLEVQRPGRRVLDYKSFYNGSRQLIGQVFSSIGGVY
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: QOX3_STAAR
Sequence: MSHDTNTIDSRTHEGELNKLGFWIFITAEFALFGTLFATLLTLQHGGDYAGKMTTELFELPLVLIMTFALLFSSYTCGIAIYYMRQEKQKLMMFWMIITLLLGLVFVGFEIYEFAHYASEGVNPTIGSYWSSFFILLGTHGCHVSLGIVWAICLLIQIQRRGLDKYNAPKLFIVSLYWHFLDVVWVFIFTAVYMIGMVYSG
What is the function of this protein?
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
What are the official names of this protein?
Probable quinol oxidase subunit 3, Quinol oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RBFA_GEOSM
Sequence: MVKRSDKVGEEIHKIISELLIKGLKDPRIGFLTITGVKMTPDLRQATVYFTVHGSDEDKKNSEAGLNSAKGYIRKEIGQALKMRFVPEVLFKYDTSLDYGQHIESILKEIGATDDGEQS
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAB2A_XENLA
Sequence: MAAVSSVASLRGADYENGLRGVAGPSDGGQDPGEDDPMGRGTLDLEMELLEQGRRSRRVGGRTTPGRRSGGRGGSGGGGAGGLEELEDEELEEEEPGELTGDQTIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSVEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFTGHPKGFAYIEFCDKESVRTSLALDESLFRGRQIKVVPKRTNRPGISTTDRGFPRARYRARASSYSSRSRFYSGYTPRPRGRVYRGRARATSWYTPY
What is the function of this protein?
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product.  Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length.  Increases the affinity of poly(A) polymerase for RNA.  Binds to poly(A) and to poly(G) with high affinity.  May protect the poly(A) tail from degradation.
What are the official names of this protein?
Polyadenylate-binding protein 2-A, PABP-2-A, Poly(A)-binding protein 2-A, Nuclear poly(A)-binding protein 1-A, Poly(A)-binding protein II-A, PABII-A, Polyadenylate-binding nuclear protein 1-A, XLnPABP2-A, nPABP2-A, xPABPII-A.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus.
Protein: XYN1_ARATH
Sequence: MKRFTVCCFSNKIHKNGDRNPDKKSRESMEVSRKDNEEPEKQNNNNVASIIGSDRTNVIVNHDFSSGMHSWHPNCCEAFVVTAESNVSHGVLDPSKCGSYVVVKNRKETWQGLEQDITNRVKPCSLYKVSATVAVSGPVHGLVEVMATLKLESQQSQTNYQFIAKTCVFKEKWVRLEGMFSLPSLPEKVVFYLEGPSPGIDLLIQSVTIHRESEPELERVTAEDETIVVNPNFEDGLNNWSGRSCKIVLHDSMADGKIVPESGKVFASATERTQNWNGIQQEITGKVQRKRVYEATAVVRIYGNNVTTATVQATLWVQNPNQRDQYIGISTVQATDKEWIHLKGKFLLNGSASRVVIYIEGPPPGTDILLNSLTVKHAEKIPPSPPPSIENPAFGVNILTNSHLSDDTTNGWFSLGNCTLSVAEGSPRILPPMARDSLGAHERLSGRYILVTNRTQTWMGPAQMITDKLKLFLTYQISVWVKVGSGINSPQNVNVALGIDSQWVNGGQVEINDDRWHEIGGSFRIEKNPSKALVYVQGPSSGIDLMVAGLQIFPVDRLARIKHLKRQCDKIRKRDVILKFAGVDSSKFSGASVRVRQIRNSFPVGTCISRSNIDNEDFVDFFLKNFNWAVFANELKWYWTEPEQGKLNYQDADDMLNLCSSNNIETRGHCIFWEVQATVQQWIQNMNQTDLNNAVQNRLTDLLNRYKGKFKHYDVNNEMLHGSFYQDKLGKDIRVNMFKTAHQLDPSATLFVNDYHIEDGCDPKSCPEKYTEQILDLQEKGAPVGGIGIQGHIDSPVGPIVCSALDKLGILGLPIWFTELDVSSVNEHIRADDLEVMMWEAFGHPAVEGIMLWGFWELFMSRDNSHLVNAEGDVNEAGKRFLAVKKDWLSHANGHIDQNGAFPFRGYSGNYAVEVITTSSSKVLKTFGVDKEDSSQVITVDLQGL
What is the function of this protein?
Binds to and hydrolyzes insoluble and soluble xylan substrates (By similarity).  Exhibits xylanase activity (PubMed:12154138).
What are the official names of this protein?
Endo-1,4-beta-xylanase 1, AtXyn1, Xylan endohydrolase 1, Xylanase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: UBIB_PSE14
Sequence: MKLLAVRRLFRIQRVVIRYRLDDLLFALPLPWWMLAVRFVLPWRWLPRRKSELSRGVRFRLALQDLGPIFIKFGQLLSTRRDLLPEDIADELMLLQDRVPPFDQQVAINLIEEQLGARICDVFSRFDETPLASASVAQVHAACLKTGEEVVVKVVRPGLKPVIGQDLAWLFILARMAERVSADARLLHPVQVVMDYEKTIYDELDLLREAANSSQLRRNFEGSDLLYVPQVYWDWCRPKVLVMERIYGLQVTDMAGLADQRTDMKLLAERGVEIFFTQIFRDSFFHADMHPGNIFVSTVNPWSPKYIAIDCGIVGSLTPEDQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFEAAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQPQLVLLQKTLLNIEGLGRQLYPDLDLWSTAQPYLERWMRERVSPKTLFGNLQSQVEQLPHIAGMTRDLLERMSRPHASDPPRPWHERKDEPVLRLIGAALLVGGAIQGWVMSEAATQLLTLTAWPAAIMLIAGLYLIVRR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y846_PSEPF
Sequence: MVDSYDDSLDTGEKSKSQVKRELHALVDLGERLTTLKPDLQAKLPLTDALRRALADAPKHTANIARKRHLQFIGKLMRDQDTDAILTLLDQLDASTRQYNERFHNLERWRDRLIAGDDAVLEKFVVDYPDADRQQLRSLIRQAQHEVAQNKPPASSRKIFKYIRELDETQRGLR
What are the official names of this protein?
UPF0307 protein Pfl01_0846.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: HSP15_LEPIN
Sequence: MTNAVLNEKNHSVTSEETKKERVRILAPRVDIYSDEENIYLLADLPGVEEKDVQVQLEKDQLIISGKTSNKDIQGELRYSEFRTGEYKRTFTLTESVEEDRISAVYKNGVLNLTLPKRKPLTKKIEVRSE
What are the official names of this protein?
Probable 15 kDa heat shock protein.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: RPPH_POLNA
Sequence: MLDRDGFRPNVGIILLNQRSQVFWGKRIRTHSWQFPQGGIDRGENPEQAMFRELHEEVGLHPQHVQVLARTRDWLRYEVPDRFIRRDARGHYKGQKQIWFLLQLVGHDWDLNLRATNHPEFDAWRWNDYWVPLDVVVEFKRGVYEMALTELSRFVPRCEFRFDARPEQRNRYLRGGLHQRDLLANQSGEPGSFPAAGGIPSYATRPGAPFELPPGATFEPDPQTSFGVNAPTKKT
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: CDHR5_MOUSE
Sequence: MGAPALLWPSLLLPWLTVLFGQPPGTLAQTQVCSVNQTIFRVEENTTVSEPLVNIFVPDGLHVTLGPLSTPYAFRIEGKDLFLNVTPDYEENSLLQADVECKRGDAVVVRLEVFVAVLDINDNAPKFSFEIKTFNVSEDTKVNTTVIPETQLKATDADINDILVYTLQEVTPNASKFFSLEGVNYPALKLDQTLDYFKNQNMTFMLLARDTWEENVEPSHTATATLVLNTLPADLRTPWFLPCSFTDGYVCIHAQYSAVVPTGHKLPSPLIMSPGPIYAVDGDQAINQSIIYSIIAGNTDGTFIINAHDGNLTMTKSIPSPMKFTLLIRADQEDMAQYSVTQAIVEARSVTGNPLQFSQSLYYGTVVLGSEAGTAVKDKTFPSEILRIQAQYPGFPDLNSAVTYRVTNSSEFMMNKDIMLTAVPMEEARTIRVEVEASNTVTKDTATAVVEIQVSERERTPTPPEAGGTTGPSSNTTMEAPLTSGTSQRPATTSSGGSVGPFPPGGTTLRPPTPASSIPGGSPTLGTSTSPQTTTPGGDSAQTPKPGTSHPTAPTSRTSTSLMTTSSRSDSTQTPKPGTSQPMVPIPGASTSSQPATPSGSSPQTPKPGTSQSTATGPISLPSTGAGEQGDGQRFSTVDMAVLGGVLGALLLLALICLVILVHKHYRHRLACCSGKASEPQPSGYDNLTFLPDHKAKWSPTPNRKPEPSPKLAQPPLRPPSPMSSSPTPPSSTPPSPQPKASGSPKTVQAGDSPSAVRSILTKERRPEGEGGYKAVWFGKDIGAEADVVVLNEPTADVDSASASGSEGSDDDDPDQKKTLRFGVDADNTYI
What is the function of this protein?
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli.  Thereby, controls the packing of microvilli at the apical membrane of epithelial cells.  Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC.  This complex plays a central role in microvilli and epithelial brush border differentiation.
What are the official names of this protein?
Cadherin-related family member 5, Mu-protocadherin.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein.
Protein: RLMN_BACC2
Sequence: METTVRKQKKNVETKKPSIYSLQIHEMQDWLKEQGEPKFRAGQIFDWLYKKRVKNYEDMSNLSKGLRDKLSNSFDITTLNTLVKQTSSDGTIKFLFQLYDGYSIETVLMRHEYGNSICVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVEVQRALDETEERVSSLVVMGIGEPFDNYDNLMGFLRITNHEKGLHIGARHMTVSTSGIIPKIYKFAEEELQINFAISLHAPNSELRSKLMPINRAYKLPDLMEAIKYYVNRTGRRITFEYGLFGGENDQVEHAEELAALLKGVKCHVNLIPVNYVPERDYVRTPREQIFLFEKTLKDRGVNVTIRREQGHDIDAACGQLRAKERKEETR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.