PharMolix/UniProtQA huggingface dataset:
Protein: YPD1_YEAST
Sequence: MSTIPSEIINWTILNEIISMDDDDSDFSKGLIIQFIDQAQTTFAQMQRQLDGEKNLTELDNLGHFLKGSSAALGLQRIAWVCERIQNLGRKMEHFFPNKTELVNTLSDKSIINGINIDEDDEEIKIQVDDKDENSIYLILIAKALNQSRLEFKLARIELSKYYNTNL
What is the function of this protein?
Phosphorelay intermediate protein that is part of the branched SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment.  Catalyzes the phosphoryl group transfer from the membrane-bound osmosensing histidine kinase SLN1 to two distinct response regulator proteins, SSK1 in the cytoplasm, and transcription factor SKN7 in the nucleus.
What are the official names of this protein?
Phosphorelay intermediate protein YPD1, Histidine-containing phosphotransfer protein YPD1, Tyrosine phosphatase-dependent protein 1.
What is the protein family that this protein belongs to?
Belongs to the YPD1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes constitutively to the cytoplasm and the nucleus, independent on osmotic conditions and phosphorylation status of the protein.
Protein: STRA6_HUMAN
Sequence: MSSQPAGNQTSPGATEDYSYGSWYIDEPQGGEELQPEGEVPSCHTSIPPGLYHACLASLSILVLLLLAMLVRRRQLWPDCVRGRPGLPSPVDFLAGDRPRAVPAAVFMVLLSSLCLLLPDEDALPFLTLASAPSQDGKTEAPRGAWKILGLFYYAALYYPLAACATAGHTAAHLLGSTLSWAHLGVQVWQRAECPQVPKIYKYYSLLASLPLLLGLGFLSLWYPVQLVRSFSRRTGAGSKGLQSSYSEEYLRNLLCRKKLGSSYHTSKHGFLSWARVCLRHCIYTPQPGFHLPLKLVLSATLTGTAIYQVALLLLVGVVPTIQKVRAGVTTDVSYLLAGFGIVLSEDKQEVVELVKHHLWALEVCYISALVLSCLLTFLVLMRSLVTHRTNLRALHRGAALDLSPLHRSPHPSRQAIFCWMSFSAYQTAFICLGLLVQQIIFFLGTTALAFLVLMPVLHGRNLLLFRSLESSWPFWLTLALAVILQNMAAHWVFLETHDGHPQLTNRRVLYAATFLLFPLNVLVGAMVATWRVLLSALYNAIHLGQMDLSLLPPRAATLDPGYYTYRNFLKIEVSQSHPAMTAFCSLLLQAQSLLPRTMAAPQDSLRPGEEDEGMQLLQTKDSMAKGARPGASRGRARWGLAYTLLHNPTLQVFRKTALLGANGAQP
What is the function of this protein?
Functions as retinol transporter.  Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496).  Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496).  Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496).  Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031).  STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable).  Does not transport retinoic acid (PubMed:18316031).
What are the official names of this protein?
Receptor for retinol uptake STRA6, Retinol-binding protein receptor STRA6, Stimulated by retinoic acid gene 6 protein homolog.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=In the retinal pigment epithelium localizes to the basolateral membrane.
Protein: RR12_CYAPA
Sequence: MPTIQQLIRSKRTKIEKKTKSPALKACPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGALDAAGVKDRRQSRSKYGAKRPKA
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
Cyanelle 30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: 121R_IIV6
Sequence: MATIQIIIEEDNVTINVKKNQVPPIEVSPKIPPIEIENVKKNVLCPICLIAKVNTVLECTHVLCSNCVKKINVCPICRKTFQSINFFRL
What are the official names of this protein?
Putative RING finger protein 121R.
Protein: NDHK_LEMMI
Sequence: MNLIEFPSLDQTMPNSVISTTLNDLSNWSRLSSLWPLLYGTSCCFIEFAALIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAVIDAITKLRKKISREIYEDRIGSKQENRCFTINHKFHVQRSIHTGNYNKELLYQSPSTSEITSEEFFRSKSSISSHKLVN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RL19_BACTN
Sequence: MDLIKIAEEAFATGKQHPSFKAGDTVTVAYRIIEGNKERVQLYRGVVIKIAGHGDKKRFTVRKMSGTVGVERIFPIESPAIDSIEVNKVGKVRRAKLYYLRALTGKKARIKEKRVNN
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: LEUD_ACIB5
Sequence: MKAYTVEQGIVAPLDRANVDTDLIIPKQFLKSIKRTGFGDNLFDELRYLDEGYPGQDNSVRPKNPDFVLNQPRYQGATVLIARTNFGCGSSREHAPWALNEYGFRTVIAPSFADIFFNNCFKNGMLPVILPEDIVDQLFKECAAQEGYQLTIDLAAQEVRTPTGEAFKFEVDPFRKHCLLNGLDDIGLTLQNADAIRAYEEKTKQVRPWVFQEIN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: NFUA_ACTPJ
Sequence: MEQQETIHISISEAAQTHFRRLLEQQEENTNIRIFVVNPGTPNAECGVSYCPPNAVEETDTQFEYNGFSAFVDEISLPFLDEAEIDYVTDPMGSQLTLKAPNAKMRKVADDAPFIERLDYVIQTQVNPQLASHGGRVTLIEVTEDKYAILQFGGGCNGCSMVDVTLKEGIEKQLLAMFPDELAGVKDVTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: HFQ_RUMCH
Sequence: MVKNTINLQDIFLNQVRKEHIAVTIYLTNGFQLKGLVKGFDNFTVVLDTDGKQQLVYKHAISTISPMKSVNLIFNEQGKE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: WHIA_BACAH
Sequence: MVSFASETKKELTNLEMKECCEKAELSALLRMNGSLSFSNRRLSIDIQTENAAIARRIYTLLKKGYDVTVELLVRKKMRLKKNNVYIVRLVEKSREILADLHIVRDDFSFIRNISQELIEKKCCKRSYLRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDAICELMNGFDLNSKTLERRKGYITYLKEAEKITEFLNIIGAHNALLRFEDIRIVRDMRNSVNRLVNCETANLNKTIGAALRQIENIRYIDETVGLDILPDKLREIAQLRRDYQDVTLKELGEMVSGGKISKSGINHRLRKIDDIAEKLRAGETVAKK
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: DUT_ARCFU
Sequence: MAVLSGDEIRKLIQKEGLIRDYVDLETQIQPNGFDCTLRSVYRLRGCGRVDFDNSRRELPELEEVEFRDWVYLPKGVYRAKLNEVVRLGNDIMAIARPRSTLIRCGANVLTAVWDAGYEGRSEVSIVVHNDYGIWLSRNARIIQLVFIRLSSPTKGYEGVYKGENIDS
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
Protein: SYR_ACIB5
Sequence: MNTAIQAALDHAVQTLQQEGVLPSDWNNSSNLTRTKDRSHGDFASNIAMIGSKAAGMKPRDLAEKILAALPEVADISKAEIAGPGFINFFLNADQRFAILDQIQAQKESFGRSQSNAAKKIQVEFVSANPTSSLHVGHGRGAAYGMTVANLLEATGAKVDREYYVNDAGRQMDILATSTYLRYLELLGQNLVFPKNAYQGDYVKEIAQGIIDKDGDAYVREVANVYKDVPEDVQYAEELDSEGNKVVLSGDKEKHIDGLIANSQQLLGEGYRVFHQAALHAILDDIKDDLADFGVTFNQWFSEASLSAKIDEALETLDQRGFLYEKDGNIWFKSTEFGDEKDRVVKRRNGQTTYFASDIAYHLNKLQRGYTDLVDIWGSDHHGYISRVKAAIDAMGYDSKKLTVLLVQFVSLWRGGEMVQMSSRSGQFVTLRDLRKEVGNDAARFYYVMRKSEQHIDFDLDLAVSQSKDNAVYYIQYAHARICRMLEKAASTGLQFEVSAARSHAARLSLDAETEILAKLAAYPDVVLRAANAYEPHQVGNYLKELAALFHGWYNEHKVLSDDAELTQARLLLSINVQQVLRNGLELLGVSAPEAM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_CHRVO
Sequence: MSERLFVLSQHILPKLALTRLAGRFADWKGGGITTAAIRRFIARYNVDMGEAADSDPAAYATFNDFFTRALKPGVRPVADARLVCPVDGAVSQLGAIDSGRIFQAKGRDYSATALLAGDADLAARFADGHFATIYLSPRDYHRIHMPCAGRLLEMTYVPGDLYSVNPATARGVDRLFARNERVVCVFEDEQSQPFVMVLVGATIVGSMATVWHGVVNPPRRPAVEKWDYRGQDIRLAKGEEMGRFLLGSTVVLLYPAGPLKFNPQWQAASPVRMGEAMAS
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL25_DESRM
Sequence: MADTALNANLRKTATKSIVKEIRNNGGIPGVVYGKHVGSMAISVDAKDLKNILGSVTGRNTLINMNINGSKQTVMVKSLQMDPMHQNIRHVDFQQVSENTKIRTVIPVQLVGTPKGVAMGGVIQHDLRSAEIECLPNRIPEAIQVDISGLEIGDTLSVSDLNLPPGVKILDHPHTTVVGLATIKAPEPAGQPEVPPEPAEEAKAKTIEKE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: AROE_CLOB8
Sequence: MEFYGLIGEKLSHSLSPKIHNTLFKDLKIEGAYKLFEVEKENLGKLIESIKLLKIKGVNVTIPYKQDVMEYLDFISDEAKKIGAVNTIYLEDNKLYGYNTDYYGFGTILNNNEIVIRDNVAMVLGNGGAAKAVITYLLDHGIKKIYLVSRKIKGNSADKDERIEFKTYEEISEIKGDILINTTPLGMYPKVDDTPVNEDIINNFNSLIDIIYNPRETRFLKIGKNSNKKVCGGIEMLVGQAIKAEEIWQECQLDNKLTQGLYSIFENEFK
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: RF1_SHEB8
Sequence: MKESVIRKLEGLLERNEEVMALLGDASVISDQDRFRALSKEYAQLEDVVAGFKAYQQAQADLDSAKEMLEEDDAEMREMAQEEMKAAKAKLEHLEDELQILLLPKDPDDDKNAFVEIRAGAGGDEAAIFAGDLFRMYSRYAEANRWQIEIMSCNEGEHGGFKEVIMKVSGEGVYGKLKFESGGHRVQRVPETESQGRVHTSAVTVVVLHEVPEAEAISINPADLKVDTFRSSGAGGQHVNKTDSAIRITHIPTGIVVECQDQRSQHKNRAQAMSVLAARIQAVEDEKRRSAEESTRRSLVASGDRSERVRTYNFPQGRVSEHRINLTLYRLNEVMEGDLDAILLPLMQEHQADQLAALADEQG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRC1_CAEBR
Sequence: MIDGVEESDAPLSPKSPFARRNGRSLRIQRLVDCQHFHYTTVELGPVKVVIIAINTDENATERIKMRVESESNSWLVERSREDWAVFDRQLHRCVFERRHSRLDELFPLIHLESAKFEEVLVKYTERLSELTGSIITCYPVLKFLEIDSRGGHFEPAEETSINVPAIAAAVVTKDFEPTDNSQLRLRVGDIVSITEMSTASPNEQTFWKAKLTISNQKIVDPQNGHLGFEIGYFPRDCVMLIDDKRLPNPLNTEPKPAPRNARRYMTTMFRNRRREPIFGLELTELFMRTGKRVPVIVERCCAAIEDQGIVTGIYRQCGIQSNIQRLRAKFDSGAEPDLHEFGQRDIYSVSSLLKQYFRQLPNPLFTYQAYPALIETFEKEESVEEKVESLRFLLEAMPEHLSRLCKSKSLTDMTSKNLAIVWSPNLFRPPPTLNGADAHLLSGLNVHTAICDFCIENSDSLFICDIDEEQSKCTSIENSFTTISKSATMSDMRSESDSRWPRFFRGKSVEGFWKFNRKQQTSTGELCGSPPSEVKWRSRSTRSHSTDATFQSSRADSFMQLMHTGMDQIREGMRIFRARARSMRPTSRPPPSPRTRRARFSNGGGANNVQRVNERERDIQIELPLATAESSITPEPRSTMDSNNIMTRTVSVNDSDDASFEENGLKEIRERKVMFKAATQEHVAPIHERSSPVEEWSSDSRESLHLEMSRYDNVSPSGTITRSQREPISNLSPAAQLLFFESSRASQLFSA
What is the function of this protein?
Functions as a GTPase-activating protein (GAP) for ced-10/RAC-1 and CDC42.
What are the official names of this protein?
GTPase-activating protein rrc-1, RhoGAP for Rac-1 and Cdc-42.
Protein: NADK_PARPJ
Sequence: MQVTSQFKTVALVGRNNTPGIAEPLTALASCIAKRGFEVVFEADTAAEIGVTDYPALRPAEIGARADVAVVLGGDGTMLGIGRQLAPYRTPLIGINHGRLGFITDIPISDMREIVPQMLSGNFEREERVLLEARIMRGGNPIYHALAFNDVVVNRSGFSGMAELHVSVDGRFMYNQRSDGLIVATPTGSTAYALSSQGPILHPQLQGIVLVPIAPHALSNRPIVLPDDSKVSIQIVSGREVNVNFDMQSFTSLELGDTIEVRRSRHTVPMLHPVGYSFFTTLRKKLHWNEYPSHEEDSKP
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_JANSC
Sequence: MTATAPITQDVRTFPRKLPDGPVNLIGLTRDGLRAALIEAGTPEKQAKMRTGQIWQWLYQKGVRDFASMTNLSKDYRAMLAETFVADVPEVVSRQVSADGTRKYLVRIAGGHEVEVVYIPEVDRGTLCISSQVGCTLTCSFCHTGTQKLVRNLTAGEIIGQVMLARDDLDEWVPTGEGSDAKPRLVSNIVLMGMGEPLYNFENVRDAMKIAMDPEGISLSRRRITLSTSGVVPEIAKTAQEIGCQLAVSFHATTDDVRDKLVPINKRWPIADLLDALRDYPRVSNSERITFEYVMLKDVNDSDADARRLVQLIKGIPAKINLIPFNEWPGAPYERSDWARIEAFADIIYKAGYASPIRTPRGEDIMAACGQLKSATERARKSRKQIEAEAGL
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_MYCTO
Sequence: MTAKSVVVLDYGSGNLRSAQRALQRVGAEVEVTADTDAAMTADGLVVPGVGAFAACMAGLRKISGERIIAERVAAGRPVLGVCVGMQILFACGVEFGVQTPGCGHWPGAVIRLEAPVIPHMGWNVVDSAAGSALFKGLDVDARFYFVHSYAAQRWEGSPDALLTWATYRAPFLAAVEDGALAATQFHPEKSGDAGAAVLSNWVDGL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INSB6_ECOLI
Sequence: MPGNSPHYGRWPQHDFTSLKKLRPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDSLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ
What is the function of this protein?
Absolutely required for transposition of IS1.
What are the official names of this protein?
Insertion element IS1 6 protein InsB, IS1e.
What is the protein family that this protein belongs to?
Belongs to the transposase 27 family.
Protein: ZRAB3_MOUSE
Sequence: MPTAGSKKKAPTPQISCLTSESYTQLDFLPDKLRTKLLPFQKDGIVFALRRDGRCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNKTDIGRIPGSRVTVLGYGLLTTDAETLLDALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYFGKRRQWDCRGASNLSELHQLLNDIMIRRLKSEVLSQLPPKVRQRIPFDLPPAAVKELNASFEEWQKLMRAPNSGAMETVMGLITRMFKQTAIAKAGAVKDYIKMLLQNDSLKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDSLMWAMLNRKAQVTGSTLNGRKEKLQATEDDKEKWGFLQFAEAWTPSDSFEELKDSVFTHFEKEKQHDIRSFFLPKLKKRQLETTCDDPEAFKEKITVASDPRKMATSDSTADKNGCEPEAKRLKSLSTEDHSSALEEGPSLQARATSMEVVHEVKPPLASPALPEKGWQCGFCTFLNNPGLPYCEMCENPRSRAAGRNHLQDNNKNDEDAAQESTSKSDQAGLECERQCPERLEAEQSANSKEEALEGGGEDRLPSQPEIGQLNNSGTLPVRETFMFCASRNTDRIHLYTKDGKPMNCNFIPLDIKLDLWEDLPATFQLKQNRSLILRFVREWSSLTAMKQRVLRKSGQLFCSPLLASEEITKQQAKENNTRRYITKEDVAKASMNKVKSDGGHIRLITKESMTQDSSLKKIDSACVPSLNPCPADLTVEPSPSKGYIQAVDKEGRPLCLRCQHPTCQPEQTAKASAWDSRFCSLKCQEEFWIRSNNSYLRAQVFATEHGVCQHCGVDAQELFLRMRDAPKSHRKSLLNAAWTAKLPLEQLNEMLRNPGEGHFWQVDHIRPVYEGGGQCSLDNLQTLCTVCHKERTAQQAKERSQVRRLSLATKHGSDITRFLVKK
What is the function of this protein?
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events.  Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase.  In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
What are the official names of this protein?
DNA annealing helicase and endonuclease ZRANB3, Annealing helicase 2, AH2, Zinc finger Ran-binding domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA.
Protein: MEND_VIBCM
Sequence: MNRDQALLNRLWSRVLLEELSRLGVTQVCVAPGSRSTPLTLEANANTAFTLHTHYDERGLGFMALGLAKASQQPVAVIVTSGTAVANLLPAIAESKLTGERLVVLTADRPLELVGCGANQAIVQSGIFSSHVTASLELPSPAIHHPLSWLLTSIDEVMARQALLGGSVHINCPFPEPLYSAGDEAIYQPYLQPVQRWREQARPYTQVHQGLVQSVPAAIDGLLTKGVVIVGSLSLQEAQAAKRFAKAMGWPLLCDPQSGISSQWAHFDLWLQHPKAREQLNQAQCVVQFGSRIVSKRLLQWLEAWCATGLGEYHYIAPHSARNNPWHAMQQQWVCEISHWVDAVLSKRLAGQHTQQGWADELTHYAQSVRQLAQLHFSSSSLSEVALALDLTERATQADLFLGNSLIVRLVDIFSALDGREVFSNRGASGIDGLVATASGVQRARQKPLLMLLGDTSLLYDLNSLALMRNPAQPTVIVVTNNDGGAIFDLLPVPSEQREALYQMPHGMDFAHAASQFGLAYCAAQTLEHYQTLVEEHFAHGAGTLLIEVKTPPQQASMHIKQLTSQLHAL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: DACH1_MOUSE
Sequence: MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASSASSSAAATVTSPGGGGGGSGGGGGSGGNGGGGGSNCNPSLAAGSSGGGVSAGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVGSSGGSWDKETLHSPPSQGSQAPVAHARMPAAFSLPVSHPLNHLQHSHLPPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRIHIEKDETPLSTPTARDSIDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASADSLRVLNDSLTPEIEADRSGGRADAERTIQDGRLYLKTTVMY
What is the function of this protein?
Transcription factor that is involved in regulation of organogenesis.  Seems to be a regulator of SIX1, SIX6 and probably SIX5.  Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex.  Transcriptional activation seems also to involve association of CREBBP.  Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter.  Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity).  Binds to chromatin DNA via its DACHbox-N domain.
What are the official names of this protein?
Dachshund homolog 1, Dach1.
What is the protein family that this protein belongs to?
Belongs to the DACH/dachshund family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPC_CLOK1
Sequence: MILDDIVGVKKKELEIRKESKPLKDIVDELSRIDEFKIRNFKGALINDDISIIGEIKRASPSKGIIDRKFEFEDICSTYETLDIDAVSVLTEQHYFKGKDEYLKKAKEFISKPVLRKDFIVDEYQVYESKLLGADAVLLIVRILKENLDKFYKIASSIGLQCIVEVHNKSELDIALKIEPEIIGINNRNLENFTVDLKNTENLINYMPENTAVISESGIKTSMDFKYIKSLPINGVLIGEGLMKKIYDIESIKKFIDSVKSG
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.