PharMolix/UniProtQA huggingface dataset:
Protein: FTSH_THEMA
Sequence: MNRSNIWNLLFTILIIVTLFWLARFFYVENSPVSKLSYTSFVQMVEDERSVVSEVVIRDDGVLRVYTKDGRVYEVDAPWAVNDSQLIEKLVSKGIKVSGERSGSSSFWINVLGTLIPTILFIVVWLFIMRSLSGRNNQAFTFTKSRATMYKPSGNKRVTFKDVGGAEEAIEELKEVVEFLKDPSKFNRIGARMPKGILLVGPPGTGKTLLARAVAGEANVPFFHISGSDFVELFVGVGAARVRDLFAQAKAHAPCIVFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFDSKEGIIVMAATNRPDILDPALLRPGRFDKKIVVDPPDMLGRKKILEIHTRNKPLAEDVNLEIIAKRTPGFVGADLENLVNEAALLAAREGRDKITMKDFEEAIDRVIAGPARKSKLISPKEKRIIAYHEAGHAVVSTVVPNGEPVHRISIIPRGYKALGYTLHLPEEDKYLVSRNELLDKLTALLGGRAAEEVVFGDVTSGAANDIERATEIARNMVCQLGMSEELGPLAWGKEEQEVFLGKEITRLRNYSEEVASKIDEEVKKIVTNCYERAKEIIRKYRKQLDNIVEILLEKETIEGDELRRILSEEFEKVVE
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: 3BHS_VACCC
Sequence: MAVYAVTGGAGFLGRYIVKLLISADDVQEIRVIDIVEDPQPITSKVKVINYIQCDINDFDKVREALDGVNLIIHTAALVDVFGKYTDNEIMKVNYYGTQTILAACVDLGIKYLIYTSSMEAIGPNKHGDPFIGHEHTLYDISPGHVYAKSKRMAEQLVMKANNSVIMNGAKLYTCCLRPTGIYGEGDKLTKVFYEQCKQHGNIMYRTVDDNAVHSRVYVGNAAWMHVLAAKYIQYPGSKIKGNAYFCYDYSPSCSYDMFNLLLMKPLGIEQGSRIPRWMLKMYACKNDMKRILFRKPSLLNNYTLKISNTTFEVRTNNAELDFNYSPIFDVDVAFKRTRKWLEESE
What is the function of this protein?
Catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids.  The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.  During viral infection, steroid production contributes to virulence by inhibiting the host inflammatory response.
What are the official names of this protein?
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase, 3-beta-HSD.
What is the protein family that this protein belongs to?
Belongs to the 3-beta-HSD family.
Protein: RL19_SINFN
Sequence: MNIIEQLEAEQAAKIAAKRTLPDFSAGDTVRVNVRVVEGSRTRVQAYEGVCIARSGGGLNESFTVRKISYGEGVERVFPVYSPLVESVEVVRRGKVRRAKLYYLRDRRGKSARIVENTGTRARKLNEAERQAVAEEKARIEAEKVAAAQALAAEKAAAEAAEKAAAEAKAAEAAAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RL17_ALIF1
Sequence: MRHRKSGRQLNRNSSHRKAMFSNMASSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEVVAKLFTELGPRFAQRAGGYTRILKCGFRAGDKAPMAYIELVDRPEVEADAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: DEF_DEHMC
Sequence: MAIRRICELPEPVLRKKAKKVPSIDGSIQTLIDDMIETMNSADGAGLAAPQVGVSLRLVVFREPDTKEATVLINPEIVKKEGQRQVTEGCLSIPGYFGELTRAETVTAKGLDRHGKACRIKGTGIVAQLLEHETEHLDGILYIDHLESEDQLHEIGPDDEMPEEIRE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: GCSP_SHIDS
Sequence: MTQTLSQLENSGAFIERHIGPDAAQQQEMLNAVGAQSLNALTGQIVPKDIQLATPPQVGAPATEYAALAELKAIASRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVASDVHPQTLDVVRTRAETFGFEVIVDDAQKVLDHQDVFGVLLQQVGTTGEIHDYTALISELKSRKIVVSVAADIMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEYKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPIGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAGVLARAEAAEINLRSDILNAVGITLDETTTRENVMQLFSVLLGDNHGLDIDTLDKDVAHDSRSIQPAMLRDDEILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYQQMIAQLADWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLADLRAKAEQAGDNLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKKASQVAILNANYIASRLQDAFPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESESKVELDRFIDAMLAIRAEIDQVKAGVWPLEDNPLVNAPHIQSELVAEWAHPYSREVAVFPAGVADKYWPTVKRLDDVYGDRNLFCSCVPISEYQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: TRUA_THEVO
Sequence: MTHAYFFKFGYIGYMFTGYQRGNGVKSVEDTIIKALNLNSPSLIKTAARTDRGVSALSNVFYIETERRPQDIAGIINSKNEYVFVHSFAEVEHGRNPRYCDTKTYMYMLPGETECDSLMVTASGFLGFHDFSKFSKKDTRNPWRSIDEVKCHRESFGVVLEFSAKSFLWNQVRRMLAFILEFRGNKIDPFSVSNIYSHIAPPENLILKDIVYKDLSFKPLNNGLKRQRLMMEKSLISYIVLKNVLG
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: SYE_ACTPJ
Sequence: MNIETLFPLDPNVKVRTRFAPSPTGYLHVGGARTALYSWLYAKHFNGEFVLRIEDTDLERSTPEATAAILEGMEWLNLAWEHGPYYQTKRFDRYNQVIDQMIEQGLAYRCYCSKERLENLRHEQEANKEKPRYDRHCLAHHDQPTDAPHVVRFKNPQEGSVVFDDAVRGRIEISNSELDDLIIRRTDGSPTYNFCVVVDDWDMGITHVVRGEDHINNTPRQINILKALGAPIPTYAHVSMINGDDGQKLSKRHGAVSVMQYRDDGYLPEALINYLVRLGWGHGDQEIFSREEMIELFDIHSVSKSASAFNTDKLQWLNQHYMRSLPAEHVAKYLAWHMNDQAIDTSNGPALEEIIPVLSERAKTLKELAAASRYFYQEFDGYDEKAAAKNFKAEAVAPLAKLLEKLTALTDWSVEAIHDAMNATAADLEIGMGKVGMPFRLAVTGSGQSPSMDITAKLVGRERTLARIQKAIEFIQAQA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NLGN2_RAT
Sequence: MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRTPGPGTSGTRRPPPPATLPPESDIDLGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPTAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV
What is the function of this protein?
Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members.  Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells.  Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors).  Functions by recruiting and clustering synaptic proteins.  Promotes clustering of postsynaptic GABRG2 and GPHN.  Promotes clustering of postsynaptic LHFPL4 (By similarity).  Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing.  Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency.  May promote the initial formation of synapses, but is not essential for this.  In vitro, triggers the de novo formation of presynaptic structures.  Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion.
What are the official names of this protein?
Neuroligin-2.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Postsynaptic cell membrane. Presynaptic cell membrane. Note=Detected at presynaptic membranes in retina, and at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes.
Protein: ROS1A_ORYSJ
Sequence: MQDFGQWLPQSQTTADLYFSSIPIPSQFDTSIETQTRTSAVVSSEKESANSFVPHNGTGLVERISNDAGLTEVVGSSAGPTECIDLNKTPARKPKKKKHRPKVLKDDKPSKTPKSATPIPSTEKVEKPSGKRKYVRKKTSPGQPPAEQAASSHCRSELKSVKRSLDFGGEVLQESTQSGSQVPVAEICTGPKRQSIPSTIQRDSQSQLACHVVSSTSSIHTSASQMVNAHLFPPDNMPNGVLLDLNNSTSQLQNEHAKFVDSPARLFGSRIRQTSGKNSLLEIYAGMSDRNVPDLNSSISQTHSMSTDFAQYLLSSSQASVRETQMANQMLNGHRMPENPITPSHCIERAALKEHLNHVPHAKAAVMNGQMPHSYRLAQNPILPPNHIEGYQVMENLSELVTTNDYLTASPFSQTGAANRQHNIGDSMHIHALDPRRESNASSGSWISLGVNFNQQNNGWASAGAADAASSHAPYFSEPHKRMRTAYLNNYPNGVVGHFSTSSTDLSNNENENVASAINSNVFTLADAQRLIAREKSRASQRMISFRSSKNDMVNRSEMVHQHGRPAPHGSACRESIEVPDKQFGLMTEELTQLPSMPNNPQREKYIPQTGSCQLQSLEHDMVKGHNLAGELHKQVTSPQVVIQSNFCVTPPDVLGRRTSGEHLRTLIAPTHASTCKDTLKALSCQLESSRDIIRPPVNPIGPSSADVPRTDNHQVKVSEETVTAKLPEKRKVGRPRKELKPGEKPKPRGRPRKGKVVGGELASKDSHTNPLQNESTSCSYGPYAGEASVGRAVKANRVGENISGAMVSLLDSLDIVIQKIKVLDINKSEDPVTAEPHGALVPYNGEFGPIVPFEGKVKRKRSRAKVDLDPVTALMWKLLMGPDMSDCAEGMDKDKEKWLNEERKIFQGRVDSFIARMHLVQGDRRFSPWKGSVVDSVVGVFLTQNVSDHLSSSAFMALAAKFPVKPEASEKPANVMFHTISENGDCSGLFGNSVKLQGEILVQEASNTAASFITTEDKEGSNSVELLGSSFGDGVDGAAGVYSNIYENLPARLHATRRPVVQTGNAVEAEDGSLEGVVSSENSTISSQNSSDYLFHMSDHMFSSMLLNFTAEDIGSRNMPKATRTTYTELLRMQELKNKSNETIESSEYHGVPVSCSNNIQVLNGIQNIGSKHQPLHSSISYHQTGQVHLPDIVHASDLEQSVYTGLNRVLDSNVTQTSYYPSPHPGIACNNETQKADSLSNMLYGIDRSDKTTSLSEPTPRIDNCFQPLSSEKMSFAREQSSSENYLSRNEAEAAFVKQHGTSNVQGDNTVRTEQNGGENSQSGYSQQDDNVGFQTATTSNLYSSNLCQNQKANSEVLHGVSSNLIENSKDDKKTSPKVPVDGSKAKRPRVGAGKKKTYDWDMLRKEVLYSHGNKERSQNAKDSIDWETIRQAEVKEISDTIRERGMNNMLAERIKDFLNRLVRDHGSIDLEWLRYVDSDKAKDYLLSIRGLGLKSVECVRLLTLHHMAFPVDTNVGRICVRLGWVPLQPLPESLQLHLLEMYPMLENIQKYLWPRLCKLDQRTLYELHYQMITFGKVFCTKSKPNCNACPMRAECKHFASAFASARLALPGPEEKSLVTSGTPIAAETFHQTYISSRPVVSQLEWNSNTCHHGMNNRQPIIEEPASPEPEHETEEMKECAIEDSFVDDPEEIPTIKLNFEEFTQNLKSYMQANNIEIEDADMSKALVAITPEVASIPTPKLKNVSRLRTEHQVYELPDSHPLLEGFNQREPDDPCPYLLSIWTPGETAQSTDAPKSVCNSQENGELCASNTCFSCNSIREAQAQKVRGTLLIPCRTAMRGSFPLNGTYFQVNEVFADHDSSRNPIDVPRSWIWNLPRRTVYFGTSIPTIFKGLTTEEIQHCFWRGFVCVRGFDRTSRAPRPLYARLHFPASKITRNKKSAGSAPGRDDE
What is the function of this protein?
Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (Probable).  DNA demethylase that is indispensable in both male and female gametophyte development (PubMed:22448681).  Involved in the regulation of DNA methylation in the promoters of RISBZ1/BZIP58 and DOF3/RPBF, two transcription factors that functions synergistically to positively regulate genes that are key players in the development of aleurone layers (PubMed:30275307).  Active DNA demethylation carried out by ROS1A in rice endosperms may restrict the number of aleurone cell layers (PubMed:30275307).
What are the official names of this protein?
Protein ROS1A, Protein REPRESSOR OF SILENCING 1 homolog a, Protein ROS1 homolog, OsROS1, Protein THICK ALEURONE 2.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase family. DEMETER subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL22_LAWIP
Sequence: MESKACAKFIRVSPRKARLIASNVKGKTVELAMNILKFTPNKSAGIILGVMRSALANAEHNAKLDVDTLIVKEVIVNEGPTWKRFMPRAQGRATHIRKRSSHISVVLSEGQE
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: DOF44_ARATH
Sequence: MDNLNVFANEDNQVNGLKRPPPSRVCPRCDSDNTKFCFYNNYSESQPRYFCKNCRRYWTHGGALRNIPVGGSCRKPKRLKVDQSSISEMVSVENQPINHQSFRQTQENNEFVRSFDASSSATVTAVPNHFGYLSELHGVTNLLPIQSFRTMDCLDFGDESFQQGYYDVGSNDLIDNPLINQSIGGYVDNLTSYCINQVEPKLQPRYEHES
What is the function of this protein?
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
What are the official names of this protein?
Dof zinc finger protein DOF4.4, AtDOF4.4.
What are the subcellular locations of this protein?
Nucleus.
Protein: GRIN3_MOUSE
Sequence: MGTVPDPLRVTKASIVAASGKEESRGESQSVSPQPAQPDNNASGIGNVPAELSLQLSAAAQALMQACVSESSQQDMASPGVFSEGEPVSPKQKTPDDFLLHGSKESAAPGLNATAQKELISAPCLISVVQHTHHAIQRDAPNTSTCAVPEGSLVKSEANSNGENPEKPGCPARVTCCSSKNQEGLCDFPSPENSQGILQTPDIASPSADRPEGEGQKVINNITAVSSEPPVREGCSENKQPSATALNTTAERSENPPPSHLTSKGATCSSEARQALLPAQYPVSRFKEASTMTCQAESGAKEVSGRAWQDAEVQAVASVESRSVSTSPSILPAYLKENPAPELENGQEQLRVICHGKGSGNHLLELSNSMVDSQESRQCPSIVPQVHIQAATATPAAFKGGCKPANQPAEGLKSPLIHVTSSQNTETEEDLRLSASKEATSRQPEGTNPDFQKANAIGQISLPAGSQAEINQGLWNSGPREPEIVVKTAKDHKAESSCKPSNSGGGANKDYPPESLDPTDKKGAKDKKPASPLIVKDHAPGATSTLDAKTLLLNPKSQVKEGEGPEVSPAPSPGRKSQQNTLEELRQPKTVMSLSLPSDGTGDSSPGSGKRTPSLSVKASPRRGSRVSEFLKELSVTAAAAQVGLTPGEKKKQLGADSKLHLKQSKRVRDVVWDDQGMTWEVYGASLDPESLGVAIQNHLQRQIREHEKIVKTQSGQTRRSISSDSSSSKKLKGRQHGVLQSMLQNFRRPNCCVRPAPSSVLD
What is the function of this protein?
May be involved in neurite outgrowth.
What are the official names of this protein?
G protein-regulated inducer of neurite outgrowth 3, GRIN3.
Protein: HRCA_ARTS2
Sequence: MSEPRKLEVLRAIVEDYVHSREPVGSKALVERHHLGVSSATIRNDMAALEDEGLITAPHTSAGRIPTDKGYRLFVDQISAVKPLSQAERRAIQTLLEGSEDLDDVLERTVRLLSQLTNQVAVVQYPHLSRAMVRHIEFVLLAPRQVLIVLIADTGKVEQRVIDVGQELGDDALAGLRARFLKSLAGTPLSLLPQALPAVVAGCEPSRRHAAQALARGLDALASSSREERMVMAGTANLARSNVDFPLSIGPVLEALEEQVVMLRLLSDMAQDPRGVTVSIGRENPYDGLAEASVVATGYGPGSSAKVGVLGPTRMDYPTTMAAVRAVARYLSRILGP
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: PEPC_PIG
Sequence: SVIKVPLKKLKSIRQAMKEKGLLEEFLKTHKYDPAQRYRIGDISVALEPMAYLEAAYFGEISIGTPPQNFLVL
What is the function of this protein?
Hydrolyzes a variety of proteins.
What are the official names of this protein?
Gastricsin, Pepsinogen C.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS2_BACAA
Sequence: MENTFKLLFETIEERKRNPLPESYTNYLFSKGEDKILKKIGEECTEVIIASKNNDKEELVKEMVDVLYHCFVLLAEKNIPLEDIMEEVTERNGKLSRVGDRREIDTL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUV1_PONPY
Sequence: MLAARRLLGWSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGALSRGDWYKTKEILLKGPDWILGEIKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNYPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDAQPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQHQAQQAAS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, Complex I-51kD, CI-51kD, NADH-ubiquinone oxidoreductase 51 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I 51 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: SSUB1_PSEAB
Sequence: MSGLLDLLEIRKAYGDTRVLEGVALSLAPGEVVSLLGPSGCGKSTLLRIAAGLDDDFQGTVERNPILGFGPDGENGRSGGIGVVFQEPRLLPWLTVAQNVGFADGWLEDEHWVERLLADVGLAGCGGLLPKQLSGGMAQRAAIARGLYGRPQVLLLDEPFSAVDAFTRMRLQDLLQDVVQNYEISVLLVTHDLDEAFYLADRVLLMGGRPGHIRREFHVPLARPRDRRAVELAYLRGEALTEMQRAHVL
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GGA3_RAT
Sequence: MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEAVQALTVLEACMKNCGRRLHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKAKVIELLFSWTLALPEEAKIKDAYHMLKRQGIVQSDPPIPMDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLRSKNPDDLQEANQLIKSMVKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHYSQEFSSEADKELMKELFDRCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQIINGEVTTSTVPDSEGNSHCGNQGALIDLAELDTPSSSSPVLAPAPAPPTSGIPILPPPPQTSGPPRSRSSSQAEAPSGPDSTNNALSLLDEELLCLGLSDPAPTAPKESAGNSPWHLFQNEPSSDLDFFSPRLVSAASCPSEGSLLPPPVSTSSLSQAPLPAAFPAPVVPASAVTHSTGSFTFSSGPAPALVPKAEPEGPEYPSSSISHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASTPARPLLPFSTGPGSPLFQSPAFQSQGSPQKGPELSLASVHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPMKEKVRLRYKLTFALGEQLSTELGEVDQFPPVEQWGNL
What is the function of this protein?
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes.  Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif.  Mediates export of the GPCR receptor ADRA2B to the cell surface.  Involved in BACE1 transport and sorting as well as regulation of BACE1 protein levels.  Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation.  Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (By similarity).  Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (PubMed:26446845).
What are the official names of this protein?
ADP-ribosylation factor-binding protein GGA3, Golgi-localized, gamma ear-containing, ARF-binding protein 3.
What is the protein family that this protein belongs to?
Belongs to the GGA protein family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein.
Protein: DPOL_NPVBM
Sequence: MKIYSYNELKTRFAEYAKPGEFSITSADTFRIIRLHYDEKQGCLFAFCNTNIEKRVLQFYFKVKLNLYSYKQCYDKHIFPSCRNKCISYTTFVAPGVEGNCLNKINVIKYERNKAAPSDNAACLDKFLHNVNRVHMQTPFVEGAYMRFKKTQRCQNNYVGGSTTRMFNLQHFYEDFELVDEMTLTSGIMPVLSCYDIETHSDGHNMSKASVDCIMSIGFVVYKNDEYARFCFMYHKLPTEIPETHDDDTHVVMFQNEVDMITAFFDMIKITNPDVILDFNGDVFDLPYILGRLNKTKMLLKRYDLPAAAPTTKLFINKLGNKVDTYYFNYYIHIDLYKFFSSDSNQHKVENFQLNTISSYYLGENKIDLPWTEMVKMYNTRRLDVIAKYNVQDCMLPIKLFVKLKMADSVYSQCILHRLCTDDVICNISHLISVACFYAAITNTRINESTGKEEPDPYFFNKNDLSIISGQFNADKATAGISNLKRKLTPLKNIPKDAINLGPANQTVKYKGGKVLQPRASIYKNAFSLDFNSLYLTIMIAICACLSNLVLCEDGNVYLNHNSRAIVVKLLLKLLSERCKFKKNRDNQSESAFLYDLYDQKQNSVKRTANSIYGYYGIFYKVLANYITRVGRNQLRRAISLIEGLSNDPEILKKFNLNSIGFKVVYGDTDSTFVLPTFNYNEIFDETDTLKQICTHVETRVNSSFTDGYKMAFENLMKVLIILKKKKYCYLNSENKIVYKGWLVKKDMPVFMRIAFRTAVEQILRHLDINKCLQSLQASFYEYYDEFAKSKPMTDYSFSMTYNDNPGKKRKSADDNNEGPSPKRRVITVARHCREILVNKGTDFVPGNGDRIPYLLIDIEGKVTEKAYPLRLFDPVKMRISWIKHMGILCTFMNELLEIFGDEQKDNLAKCFTAIMQKYMQNQLYDRKEPVLVKINQKKCSVKRKRDDDDDNNDDDDDDGCDSSDSENDTQCANNTYKFCLYKIKK
What is the function of this protein?
Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: UREND_METTH
Sequence: MTVLKIISWNVNGLRAVHRKGFLKWFMEEKPDILCLQEIKAAPEQLPRKLRHVEGYRSFFTPAERKGYSGVAMYTKVPPSSLREGFGVERFDTEGRIQIADFDDFLLYNIYFPNGKMSEERLKYKLEFYDAFLEDVNRERDSGRNVIICGDFNTAHREIDLARPKENSNVSGFLPVERAWIDKFIENGYVDTFRMFNSDPGQYTWWSYRTRARERNVGWRLDYFFVNEEFKGKVKRSWILSDVMGSDHCPIGLEIEL
What is the function of this protein?
Involved in DNA uracil repair (PubMed:17012282, PubMed:19240141, PubMed:20129830).  Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide (PubMed:17012282, PubMed:19240141, PubMed:20129830).  In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease (PubMed:15725624, PubMed:17012282).  Strongly binds to double-stranded DNA (PubMed:15725624).
What are the official names of this protein?
DNA uridine endonuclease, DNA U-endo, DNA U-endonuclease, AP endonuclease, ExoMt.
What is the protein family that this protein belongs to?
Belongs to the DNA repair enzymes AP/exoA family.
Protein: IF3_CHLPD
Sequence: MKKQKTTTQKPKLSYRINEQIRVPEVRIIFPDGTQQVMKTIDAKRLAEEKNFDLIEVQPNADPPVCKLDNLGKLIYKMDKRDKDLKKKQKTTTLKELRFHPNTDKHDFDFKTAHLEEFLRKGNRVRATIVFLGRSIIYKDRGLELAERLTERLSCVSNRDGDPKFEGKKLFVYFEPDKKKVDAFERIKAKTGVPQQPLAPLPPSEDIEE
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.