PharMolix/UniProtQA huggingface dataset:
Protein: MATK_HUMLU
Sequence: MAEFQGYLELDRSWQHDLLYPLIFREYIYTFVHDHGLNRNRSNLLENVGYDNKSSLLIVKRLISRMYQQNHLIISANDSNQNPVFGYNKNFYSQMISEGFAVVVEIPFSLRLVSSLKGTEVVKYYNLQSIHSTFPFFEDKFPHLNYVSDVLIPYPIHLEILVQTLRYWVKDVSSLHLLRLFLHEYYSWNRFLIPNKSISIFSKSNLRFFLFLYNSHVCEYESILLFLRNQSSHLRLTSSGGFFERIYFYGKIKHPVEEVFADDFPTSLWFFQDLVIHYVRYQGKSILASKDMPLLMNKWKYYLVHLWQCHFYVWSQAGSIYINQLSKHAFGFLGYLSSMRINLSVVRSQMLENSFLMDNAMKKIDTLIPISPLIGSLAKMKFCNVVGQPLSKSTWADLSDFDIIDRFARICRNLFHYYSGSSKKKSLYRVKYILRLSCVKTLARKHKSTVRTFLKRLGSELLDEFFTEEEEVLSLIFPRTYSTLRRLYKGRIWYLDIFCINDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ILVD_SULNB
Sequence: MMRSDEIKKGYNRAPHRSLLRATGLKDEDFDKPFIGVANSFIELIPGHYFLNKVAEVIKNEIRANGCVPFEFNTIGVDDGIAMGHDGMLYSLPSREIIANSIETVMNAHKLDAMIAIPNCDKIVPGMIMGALRVDVPTVFVSGGPMAAGHMDDGTPIDLATVFEGVGEYEAGEITEETLAEMECNACPSGGSCSGMFTANSMNTLMEAMGIALPGNGTILALTPERTELYKKAARRICEIAKSEAAEREKFRMRNILNENAVRNAFAVDMAMGGSSNTVLHMLAIAKEAEVDFNLEDINMISKRVSHIAKISPSLTTVHMEDINTAGGVSSVMHEMHKRGDDILIDNPTITGESLYERIKDARILDTNIIHTIDNPFSEVGGLAILYGNLAEQGAVIKTAGITGDRAFTGTAVCFDSQDEAIEGILSGKVKAGNVVVIRYEGPKGGPGMQEMLSPTSLIMGMGLGDKVALITDGRFSGATRGASIGHVSPEAAEGGLIGLLEDGDEIHLDVDNYILEAKLTFEEIAERKDKFKPVVKPLKSKWLRQYRALVTNASNGAVLEAE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RL27_METFK
Sequence: MAHKKAGGSSRNGRDSNAQRLGVKAFGDQFVSAGSIIVRQRGTKMHPGENVGIGKDHTLFAKVDGKVAFSVKGALGRKLVSIIPA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: APT_STRSV
Sequence: MNLKDYIATIENYPKEGVTFRDISPLMADGNAYSYAVREIVQYATDKKIDMIVGPEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIERLGGVVAGCAFLIELDELKGREVIGDYDYKVLMHY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_SHESR
Sequence: MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVAAKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGENAVLAHREILGATNPAQAAPGTIRADFAQSIDENAAHGSDSLESAAREIAYFFSAEELCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PON1_HUMAN
Sequence: MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
What is the function of this protein?
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides.  Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters.  Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
What are the official names of this protein?
Serum paraoxonase/arylesterase 1, PON 1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the paraoxonase family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: TAG2B_AGEOR
Sequence: MRAIISLILISAMVFSMIAAVPEEEGLQLSEDERGGCLPHNRFCNALSGPRCCSGLRCKELSIWDSRCLG
What is the function of this protein?
Insect active toxin causing rapid but reversible paralysis in crickets.  No activity shown in mammals.  Does not show effect on mammalian voltage-gated calcium channels (By similarity).
What are the official names of this protein?
U2-agatoxin-Ao1b, U2-AGTX-Ao1b, Agel_01.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 01 (U2-agtx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PURT_ANADE
Sequence: MRKKILLLGSGELGKEFTIAAQRLGQEIIAVDAYDGAPAQQVAHAREVVSMLDGAALDALVAKHRPDVIVPEIEAIRTERLQAYEAQGVQVVPSARAAAFTMNRRAIRDLAARELGLATARYAYASTPEAFRAAVHEIGLPCVVKPLMSSSGKGQSVVRAEGDLEAAWAYAMSGTRGDLREVIVEEFIPFDSEITLLTVTQRRGETLFCPPIGHRQERGDYQESWQPHPVPPPLLEEARRMAGAVTRALGGAGIFGVEFFLAKDRIWFSELSPRPHDTGMVTLAGTQPLNEFELHLRAVLGLPIPPITLVRPGASAVILARGTGAPVVRGLESALAEPGADVRIFGKPALRPHRRMGVALVSGAPGDDPRALVERARAVAARVSVDP
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: MURA_RHILW
Sequence: MDRIRIVGGNELNGIIPISGAKNAALPLMIASLLTSDTLTLENVPHLADVELLMRILGNHGVDVAVNGRRERQEDSYSRTIHFTCRTIVDTTASYELVSKMRASFWVIGPLLAREGHCRVSLPGGCAIGTRPVDLFIEGLTALGATMEIDAGYINAKAPNGGLIGARYTFPKVSVGATHVVMMAATLARGTTVIGNAAREPEVVDLANCLNAMGAKISGAGTATITIEGVTSLSGARHRVLPDRIETGTYAMAVAMAGGDVVLENTDVALLDTALETLRRAGADISATNNGMRVKRNGAGIKPVDIVTDPFPGFPTDLQAQFMALMTRSSGISHVTETIFENRFMHVQELARLGARITLSGQTAKIEGVQRLRGAPVMATDLRASVSLVIAGLAAEGETTVSRVYHLDRGFERLEEKLTRCGAVVERISE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_CERSK
Sequence: MNILERAALTALHRMDPEKAHSLSLSALRSGLVPLPGPVTSSRLATDVGGLVLPNPVGLAAGYDKNAVALAALMRAGFGFLEVGAATPRPQPGNPQPRLFRLTEDRAAINRFGFNNDGAATICARLAMRPRGAVPVGLNLGANKDSPDRAADFAAVLAACGPHADFATVNVSSPNTERLRDLQGRQALTALLEGVMQVQAGFARPVPVFLKIAPDLSDADLAEIAEVALASGIAGIVATNTTLARDGLRSAHARETGGLSGAPLFERSTRVLARLSELTEGRLPLIGVGGVASAEEAYAKIRAGASAVQLYTAMVYQGIGLAARIARGLDALLLRDGFGSVAEAVGTGRADWLT
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: VNS3_DSDNV
Sequence: MSLMYGKYNICKRRLFETKTYNPKTLFYLSYKTARLNGLDLSTLPLTIRKLQNKIDKHILWCDEDIENVLGAERLTKWNFNIIQPLPVNVFLALQNLTEIPDWLDETMWVQFKWIYNKSTTFEFDDFQEKFIEHKHYEKICHNCFNRFLDHALQEMSTIEKTIINYIKPFDAGDILNILQDSYHWCEYCHITPLFRLIKIEY
What are the official names of this protein?
Non-structural protein NS3.
Protein: RIMM_YERPE
Sequence: MSKQLNPAVPDQPIVLGKMGSTYGIRGWLRVFSSTENAESIFDYQPWFIQQAGKWQHVELEDWKRHSQDLIIKVKGVDDREAANLLTNCEIIVDSTQLPALEEDDYYWKDLMGCQVVTTTGYELGKIIDMMETGSNDVMVVKANLKDAFGMKERLVPFLHGQVIKKVDLTAQRVEVDWDPGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLUC2_ONCMY
Sequence: MFGIHSLAGVLLLVIVQSQLASPLQEAEDNSSLETADSLLEDLRGVPNMKRQSEGTFSNYYSKYQEERMARDFLHWLMNSKRSGAPSKRHADGTYTSDVSTYLQDQAAKDFVSWLKSGPARRESAEESMNGPMSRRHVDGSFTSDVNKVLDSLAAKEYLLWVMTSKTSGKSNKRQEDH
What is the function of this protein?
Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
What are the official names of this protein?
Glucagon-2, Glucagon II.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECR_CAUSK
Sequence: MAASAGPEIERLIALLSKLPGLGPRSGRRAALALLKKRDTLLAPLTAALVDAQAKVRTCSVCGSLDTSDPCAICSDAARDNRLLCVVEEVGSLWAMERGGSFKGRYHVLGGLLSALDGVGPEALRVGELLGRAKGGEVSEVILALPATVDGQTTAHYLADRLAPTGVSVTMLARGVPVGGDLDWLDDGTIAQALRARRPA
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RLMD_BORPA
Sequence: MVDVLNIESLDLEARGIAHRDGKVLFVEGALPGERVTVQTVRRKPSYEIAKVEEILRPSSQRVAPRCPHFGVCGGCAMQHLAPAAQVAIKQRALEDTFWHVGKLKPARILPPLYGPTWGYRYRARLSVRVVPKKGGVLVGFHERKSSYVADMRECHVLPPAVSRLLLPLRAMIAAMSAPDRMPQIEVALGDEAIVLVLRHLLPLTDGDIAVLRAFAAEHGVQWWLQSKGPDTVHPLEREHADALAYTLPEFGLRMPYRPTDFTQVNHAINRAMVSRALKLLDVQPQDRVADLFCGLGNFTLPLATQGREAVGVEGSKALTDRAHEAAARHGLGERTRFATLNLFEVDVQWLRGLGYFDRMLIDPPREGAQAVVQALSLLAPGERPRRIVYVSCNPGTLARDAAIMVHEGGYALRSAGVINMFPHTGHVESIAVFESLDEATVLQAQAQARQKAREEAERLAEAAAA
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: RL14_SHEWM
Sequence: MIQMQSTLDVACNSGARRVQCIKVLGGSHRRYAGIGDIIKVSVKEAIPRGKAKKGDVYSAVVVRTKKGVRRPDGSVIRFDRNAAVLLNANNAPIGTRIFGPVTRELRTEQFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MINE_BURL3
Sequence: MSILSFLLGEKKKSASVAKERLQLIIAHERVGGRPPADYLPALQKELVAVISKYVHISNDDIRVSLERQDDLEVLEVKIEIPQA
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: YKZB_BACSU
Sequence: MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQNGQYRKSS
What are the official names of this protein?
Uncharacterized protein YkzB.
Protein: DPOL_HBVGB
Sequence: MPLSCPHFRKLLLLDEEAGPLEEELPRLADEGLNRRVAEDLNLQLPNVSIPWTHKVGNFTGLYSSTVPVFNPKWQTPSFPDIHLHQDIINKCEQFVGPLTVNEKRRLKLIIAARFYPNAPKYLPLDKGIKPYYPEHVVNHYFQTRHYLHILWKAGILYKRETTRSASFCGSPYSWEQELQHGAEPVCQQSLGILPRASVGSPVQSQLKQSRLGLQSQQRQLARSHQGRSGSIRARVHSTTRRSFRVELSGSGSNHNIASTSSSCRHQSAVRETAYSHLSTVERHSSSGHEVELYSIPPNSARSQSTGPILSCWWLQFRNSEPCSDYCLSHLVNLLEDWGPCTEHGEHHIRIPRTPARVTGGVFLVDKNPHNTTESRLVVDFSQFSRGSTRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSSGLSRYVARLSSTSRIIDHQHGTMQNLHDHCSRNLFVSLMLLYKTFGRKLHLYSHPIVLGFRKIPMGVGLSPFLLAQFTSSICSVVRRAFPHCLAFSYMDDLVLGAKSVQHLESIYTAVTNFLLSLGIHLNPNKTKRWGYSLNFMGYIIGSWGSLPQDHIVQKIKQCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPTYKAFLRTQYLTLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARSRSGANIIGTDNSVVLSPKYTSFPWLLGCAANWILRRTSFVYVPSALNPADDPSRGRLGLYRPLLRPWFRPTTGRTSLYAVSPSVPSHLPVRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: OR4D9_HUMAN
Sequence: MDQRNYTRVKEFTFLGITQSRELSQVLFTFLFLVYMTTLMGNFLIMVTVTCESHLHTPMYFLLRNLSILDICFSSITAPKVLIDLLSETKTISFSGCVTQMFFFHLLGGADVFSLSVMAFDRYIAISKPLHYMTIMSRGRCTGLIVASWVGGFVHSIAQISLLLPLPFCGPNVLDTFYCDVPQVLKLACTDTFTLELLMISNNGLVSWFVFFFLLISYTVILMMLRSHTGEGRRKAISTCTSHITVVTLHFVPCIYVYARPFTALPTDTAISVTFTVISPLLNPIIYTLRNQEMKLAMRKLKRRLGQSERILIQ
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 4D9, Olfactory receptor OR11-253.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRMD_PSEPG
Sequence: MGNLCVDVITLFPEMFSAITEYGITSRAVKQGLLQVTCWNPRDYTTDRHHTVDDRPFGGGPGMVMKIKPLEDALVSARQATGAAAKVIYLSPQGRKLTQQAVKGLAEQESLILIAGRYEGIDERFIEAHVDEEWSIGDYVLSGGELPAMVLIDAVTRLLPGALGHVDSAEEDSFTDGLLDCPHYTRPEVYADQRVPDVLLSGNHAHIRRWRMKQSLGRTFERRADLLESRSLSGEEKKLLEEYLRERDDS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDM4D_MOUSE
Sequence: MKTKSTCAQNPNCSIMIFRPTKEEFNDFDKYIAYMESQGAHRAGLAKVIPPKEWRARQSYDNISNILIATPLQQVVSGQAGVFTQYHKKKKGMTVGEYRELANSKKYQTPPHLDFEDLERKYWKNRLYESPIYGADVSGSLFDGKTQQWNVGHLGTIQDLLEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGQPKTWYAVPPEHGRRLERLARELFPGSSQGCQAFLRHKVALISPTVLKENGIPFGRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVSFSMDAFVRILQPERYELWKRGQDQAVVDHTETMVSTSQELTTRRVTKAPRKTWGLKRLRLRQVSRSLLPIATVSNVPCNMQVCHTSRQPSDVKGDDVQKSDSARASPHPLSLPSSGHMSTRRCSLGRRPCELGAQESSNGAPVKRQLPAGRDDTSPSPELQPQAVSGDLIVDSGLVNPGPQHLMTASEGGLTSDP
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.  Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'.  Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues.  Demethylation of Lys residue generates formaldehyde and succinate.
What are the official names of this protein?
Lysine-specific demethylase 4D, JmjC domain-containing histone demethylation protein 3D, Jumonji domain-containing protein 2D, [histone H3]-trimethyl-L-lysine(9) demethylase 4D.
What is the protein family that this protein belongs to?
Belongs to the JHDM3 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: G6PD_MYCS2
Sequence: MNRTPSPVDPCDFVIFGGTGDLAARKLLPALYLRDRDGQLAGATRIIGVAKAGLDDAGYRNTVRAGLARHVEPDLLDSDVVDRFLSRLRFVSVDLTEPSDYAAVGDVLTSPDGGSGHDIRVFYLACAPALFGPICGALGAQGLVTESSRVVLEKPIGRDLASAQQINEAVGAVFAEHQIFRIDHYLGKESVQQLLVTRFGNTWLEPLWNSSRIDHVQITAAESLGVGARGDYYDQSGALRDMLQNHLLQVLCLVAMEPPTHVNRESVRDEKRKVLEALEPLTAEQTQRDTVTGQYGPGLVGDEVVGSYREEVADPHSRTETFVAVKAHIRNWRWAGVPFYLRTGKRMSQRFSEIVVQFKPVPLPMFPGIEGTSEPNRLIISLQPDEAIRLEMTAKEPGSGGRLRPVSLALNYTEAFPERSPDAYERLLMDVVRGDPTLFMRRDEVEAAWAWAEPILRHWQDADRVPRTYPAGTDGPVDAATLIERDGRRWHGGAA
What is the function of this protein?
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: TRMFO_ACAM1
Sequence: MDHQQPIQVIGGGLAGTEAAWQIAQAGWPVILHEMRSVEEERLTPAHHTDQLAELVCSNSFGAQASDRAAGLLHAELRQLGSIIIRKADEHQVPAGGALAVDRGVFSRNLTETLAEHPNVELRRGEVPTLPIDGTVVLTSGPLTSAALTESLHQFTGQDYLSFFDAASPIIVGESINRDVAFLASRYDRGEAAYLNCPMNREQYLAFWQALCAAEQAELKDFEKETAKFFEGCLPIEEMARRGEDTMRYGPLKPVGLFDARYGDFKAPENQKYRPYAVAQLRQEDKAGKLWNLVGFQTNLRWGEQKRVFQMIPGLESAEFVRMGVMHRNTFINAPELLHPTLQFKQRPTLLAAGQLIGTEGYTAATAGGWLAGTNAVRLAQGLNPVVLPTTTMSGSLFEFISSATPKHFQPMPPNFGIIPDLPQRVRNKRERYGVYRDRALADLTAWIAEPSLFRQTVAANSASM
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMD_TERAN
Sequence: MKVQILFALMMVLVTLCLGQKMQRGVIEDVCNNCETNCQLIKDYYGRSFCQDSLCQDSYRFCTNLEFTMDKCKDENSNTHAGCVTALLSTS
What are the official names of this protein?
Teretoxin Tan22.13.
What is the protein family that this protein belongs to?
Belongs to the teretoxin C (TC) superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ORF6_BFDV
Sequence: MKTSPRLSVIDGVGEEVRPDLFQLVHVVPPNTCEPPEQWLRVTVLLVPGLGGLIARDNYPLAGKLHKSALDWHFMWITVAEAEHLAIR
What are the official names of this protein?
Uncharacterized protein ORF6.
Protein: AHPD_BRUC2
Sequence: MSIDDLKSKIPDFAKDVRLNLSSMASNETLTPQQKYGLFVACGIASRNADVRKALVAEAAGKVDASVIQAAKAAASIMGMNNVYYRFVHLASNKDYRTMPARLRMNVISNPGVDKVDFELWSLAVSAINGCGMCIDAHEDVLRKANVTAEAIQAAVRFASIIQSAAIALEAADTE
What is the function of this protein?
Antioxidant protein with alkyl hydroperoxidase activity.  Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
What are the official names of this protein?
Alkyl hydroperoxide reductase AhpD, Alkylhydroperoxidase AhpD.
What is the protein family that this protein belongs to?
Belongs to the AhpD family.
Protein: COBT_SOLM1
Sequence: MSRVLSEVLAAVRPVDQSLFPVAKAHLDNLTKPRGSLGRLEELAARLFVIGGGAKPVVDPARIYVCAGDHGVAAEGVSLFPQEVTRQMVANFLAGGAGINVLAATAGIDLRVVDAGCLGDPFAPHPRFAGARVASGTANLAEAPAMTREQCESALLLGVSLAEAAAAEGVRALGTGDMGIANTTPSTALFCAYLGLSPAEITGPGTGLDAGGVGRKAAIVAKGLALHADVVAGGDPVAVLACLGGLEIACLAGLVIGAAACRLPIAVDGFISTAAYVAARAICPTVADYAVVSHASAEPGYAPIMAALGQKPLLDLGLRLGEGTGAALALFLMRSACNIYNDMATFASAGVSEG
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RNH2_SULAC
Sequence: MILVGIDEAGRGSLIGPMVVAGVAIDSNFLKFLSEIGVKDSKKLTRKKREYLFGVILEYSYAISLVKAYPEEIDSENLNEITYRAMIQIIHSMSVYNPSIVTVDKVGNASAVEREIININSSPRVENNADVKYVEVSAASIIAKVVRDNIINELKKTYGDFGSGYPGDKKTVEWIKDLYSRQPTYALPIIRRSWKILQDIAPNYYIRKRDGN
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPAS1_MOUSE
Sequence: MTADKEKKRSSSELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLKNGSGFGKKSKDVSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNNCPPHSSLCGSKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSDDVAVTEKSNYLFTKLKEEPEELAQLAPTPGDAIISLDFGSQNFDEPSAYGKAILPPGQPWVSGLRSHSAQSESGSLPAFTVPQADTPGNTTPSASSSSSCSTPSSPEDYYSSLENPLKIEVIEKLFAMDTEPRDPGSTQTDFSELDLETLAPYIPMDGEDFQLSPICPEEPLMPESPQPTPQHCFSTMTSIFQPLTPGATHGPFFLDKYPQQLESRKTESEHWPMSSIFFDAGSKGSLSPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWPVGDQSAESLGALPVGSSQLEPPSAPPHVSMFKMRSAKDFGARGPYMMSPAMIALSNKLKLKRQLEYEEQAFQDTSGGDPPGTSSSHLMWKRMKSLMGGTCPLMPDKTISANMAPDEFTQKSMRGLGQPLRHLPPPQPPSTRSSGENAKTGFPPQCYASQFQDYGPPGAQKVSGVASRLLGPSFEPYLLPELTRYDCEVNVPVPGSSTLLQGRDLLRALDQAT
What is the function of this protein?
Transcription factor involved in the induction of oxygen regulated genes.  Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371).  Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung.  May also play a role in the formation of the endothelium that gives rise to the blood brain barrier.  Potent activator of the Tie-2 tyrosine kinase expression.  Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300.  Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
What are the official names of this protein?
Endothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, HLF, mHLF, HIF-related factor, HRF, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Colocalizes with HIF3A isoform 2 in the nucleus and speckles.