PharMolix/UniProtQA huggingface dataset:
Protein: HVM45_MOUSE
Sequence: MAVLGLLFCLVTFPSCVLSQVQLKQSGPGLVQPSQSLSITCTVSGFSLTSYGVHWVRQSPGKGLEWLGVIWSGGSTDYNAAFISRLSISKDNSKSQVFFKMNSLQSNDTAIYYCAR
What are the official names of this protein?
Ig heavy chain V region MC101.
Protein: RL33_PECAS
Sequence: MAKGVREKIKLVSSAGTGHFYTTTKNKRTKPEKLELKKFDPVVRQHVLYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: GSA2_STAEQ
Sequence: MKFTESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGHGAYLYDVDGNKYIDYLQAYGPIITGHAHPHITEAIQDQAAKGVLYGTPTELEINFSKKLREAVPSLEKIRFVNSGTEAVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGPSQLGSPDSAGVPQSVAQEVITVPFNDIESYREAIDYWKDDIAAVLVEPIVGNFGMVMPQPGFLEEVNKISHDNGTLVIYDEVITAFRFHYGAAQDLLGVKPDLTAFGKIVGGGLPIGGYGGRQDIMEHVAPLGPAYQAGTMAGNPLSMRAGIALLEVLEQEGVYDKLDQLGRRLEEGLQKLIDKHHITATINRIYGSLTLYFTNEKVTHYEQVENSDGDAFAQFFKLMLNQGINLAPSKFEAWFLTTEHTEEDIDRTLEAADYAFSKMK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 2, GSA 2, Glutamate-1-semialdehyde aminotransferase 2, GSA-AT 2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURE_BACAN
Sequence: MKLHTLVSCLHDFPVVPKENPEITSIEADSRKVKEGSLFVCMKGYTVDSHDFAKQAAAQGAAAIVAERPIDVDVPVVLVKNTFRSLAVLADYFYGQPTHKLHLIGITGTNGKTTTSHIMDEIMRAHGHKTGLIGTINMKIGDETFEVKNTTPDALTLQQTFAKMVEHGVDSTVMEVSSHALDLGRVHGCDYDVAVFTNLTQDHLDYHKTMEEYKHAKGLLFAQLGNSYNHNREKYAVLNNDDAVTVEYMRSTAATVVTYGIDTTSDVMAKDIAMTSGGTTFTLVTPYESVNVTMKLIGKFNVYNVLAATAAGLVSGVSLETIIDVIKELAGVPGRFEVVDGGQNYTVIVDYAHTPDSLENVLKTAKQFAKGDVYCIVGCGGDRDRTKRPIMASVATQYATHAIYTSDNPRSEDPAAILDDMVHGANGNNYEVIIDRKEAIHHAITKAKADDIIIIAGKGHETYQIIGKDVHHFDDREVAKEAITERLNNEE
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQE_METEA
Sequence: MNAPTPAPSPVDVIPAPVGLLAELTHRCPLRCPYCSNPLELDRRSAELDTQTWLRVLTEAAGLGVLHVHLSGGEPTARPDIVEITAKCAELGLYSNLITSGVGGALAKLDALYDVGLDHVQLSVQGVDAANAEKIGGLKNAQPQKMQFAARVTELGLPLTLNSVIHRGNIHEVPGFIDLAVKLGAKRLEVAHTQYYGWAYVNRAALMPDKSQVDESIRIVEAARERLKGQLVIDLVVPDYYAKYPKACAGGWGRKLMNVTPQGKVLPCHAAETIPGLEFWYVTDHALGEIWTKSPAFAAYRGTSWMKEPCRSCDRREKDWGGCRCQALALTGDAANTDPACSLSPLHAKMRDLAKEEAAETPPDYIYRSIGTNVQNPLSEKAPL
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.
Protein: HIS1_BRUME
Sequence: MSVTLAFPSKGRLKENTLAVLEKAGYKVVLPDDDRNYRARVEGEDDLDILFLSASEIARKLGYGSVDLGVTGEDLVRETLAHADERVAIEAQLGFGHADVVVAVPEVWRDVTTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGSADMIVDITSTGSTLRANRLKVLEDGIILRSQACLVSARRSHTSRRVEEIAARIRAGLEI
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10E_THEGJ
Sequence: MGLRPAKIDRDVDKPAYTRREYIRGAPGPKITIFDMGNLSAEFEYEVSLHAEQAMQIRQNALEAIRIQVNRYLQKNVGRSNYHFKIRVYPFQVLRENPMATGRKADRYGNGMRRPFGKPIGLAARVKKDQKILTVWVNEQHLKFALGAMHRAKMKLPYSAYYRIYDREGNDVTTKVLSTMKR
What are the official names of this protein?
50S ribosomal protein L10e.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: PA2HJ_TRIST
Sequence: SVIELGKMIFQETGKNPATSYGLYGCNCGPGGRRKPKDATDRCCFLHKCCYKKLTDCDPIRDSYSYSWVNKAIVCGGDDPHLKEMCECDKAMAICFRENLDTYDKKKKITLKLSCKKTSEQC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks catalytic activity (PubMed:12959640).  It shows myotoxic and weak anticoagulant activities (PubMed:12959640).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog CTs-K49b, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LSRA_ECOSM
Sequence: MQTSDTRALPLLCARSVYKQYSGVNVLKGIDFTLHQGEVHALLGGNGAGKSTLMKIIAGITPADSGTLEIGGNNYVRLTPVHAHQLGIYLVPQEPLLFPSLSIKENILFGLAKKQLSIQKMNNLLAALGCQFDLHSLAGSLDVADRQMVEILRGLMRDSRILILDEPTASLTPAETERLFIRLRELLATGVGIVFISHKLPEIRQIADRISVMRDGTIALSGKTSELSTDDIIQAITPALREKSLSASQKLWLELPGNRPQHAAGTPVLTLENLTGEGFRNVSLTLNAGEILGLAGLVGAGRTELAETLYGLRTLRGGRIMLNGKEINRLSTGERLLRGLVYLPEDRQSSGLNLDASLAWNVCALTHNLRGFWAKTAKDNATLERYRRALNIKFNQPEQAARTLSGGNQQKILIAKCLEASPQVLIVDEPTRGVDVSARNDIYQLLRSIAAQNVAVLLISSDLEEIELMADRVYVMHQGEIAHSALTGRDINVETIMRVAFGDSQRQEASC
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Autoinducer 2 import ATP-binding protein LsrA, AI-2 import ATP-binding protein LsrA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: URM1_CANAL
Sequence: MAIKIKVEFLGGLDIISNSVREHKCVIPFEEGEATVADLITYITKNIISDPKDIPVFIEDGTVRPGILVLINDTDWELEGMEEYVIESGDVFTFTSTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y381_BACP2
Sequence: MNIYQTYEPSQIRELIRKKEITGPTAGLAEGYAQANLMIVKKELAFDFLLFCQRNPAACPLLDVLEPGDPVPRKSAPKADIRTDFPKYRIYRKGILQEEVSDISAYWEDDMVAFLIGCSFTFEHALMLNDIPVRHIENGHNVPMYQTNIACKRAGVFHGPMVVSMRPIPAHQITRSVQVTSRFPSVHGGPIHIGDPAMIGIANVDQPDFGETSVIKEGEVPVFWACGVTPQAVVMHTKPEIAITHAPGHMFITDQRDQQLGVL
What are the official names of this protein?
Putative hydro-lyase BPUM_0381.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: NUOI_CUPMC
Sequence: MLLAIKDFFNSLLLKELFKGMALTGRYLFARKITVQFPEEKTPMSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAISIESDVRNDGTRRTTRYDIDLTKCIFCGFCEEACPVDAIVETHILEYHGEKRGDLYFTKDMLLAVGDRYEPQIAAAKAADAKYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CSF3_CANLF
Sequence: MAPLGPTGPLPQSFLLKCLEQMRKVQADGTALQETLCATHQLCHPEELVLLGHALGIPQPPLSSCSSQALQLMGCLRQLHSGLFLYQGLLQALAGISPELAPTLDTLQLDTTDFAINIWQQMEDLGMAPAVPPTQGTMPAFTSAFQRRAGGVLVASNLQSFLELAYRALRHFAKP
What is the function of this protein?
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.  This CSF induces granulocytes.
What are the official names of this protein?
Granulocyte colony-stimulating factor, G-CSF.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PHR_ARATH
Sequence: MASTVSVQPGRIRILKKGSWQPLDQTVGPVVYWMFRDQRLKDNWALIHAVDLANRTNAPVAVVFNLFDQFLDAKARQLGFMLKGLRQLHHQIDSLQIPFFLLQGDAKETIPNFLTECGASHLVTDFSPLREIRRCKDEVVKRTSDSLAIHEVDAHNVVPMWAASSKLEYSARTIRGKINKLLPDYLIEFPKLEPPKKKWTGMMDKKLVDWDSLIDKVVREGAEVPEIEWCVPGEDAGIEVLMGNKDGFLTKRLKNYSTDRNNPIKPKALSGLSPYLHFGQVSAQRCALEARKVRSTSPQAVDTFLEELIVRRELSDNFCYYQPHYDSLKGAWEWARKSLMDHASDKREHIYSLEQLEKGLTADPLWNASQLEMVYQGKMHGFMRMYWAKKILEWTKGPEEALSISIYLNNKYEIDGRDPSGYVGCMWSICGVHDQGWKERPVFGKIRYMNYAGCKRKFNVDSYISYVKSLVSVTKKKRKAEEQLTRDSVDPKITIV
What is the function of this protein?
Involved in repair of UV radiation-induced DNA damage.  Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutylpyrimidine dimers (CPDs), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.  Required for plant survival in the presence of UV-B light.  Not involved in the repair of (6-4) photoproducts.
What are the official names of this protein?
Deoxyribodipyrimidine photo-lyase, AtCPDII, DNA photolyase, Photoreactivating enzyme 1, Protein UV RESISTANCE 2.
What is the protein family that this protein belongs to?
Belongs to the DNA photolyase class-2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FPG_EXISA
Sequence: MPELPEVETVCRRLRPAVSGKTIQSVDVLDPKIIRGLDPEEWVHHLIGETITDVERRGKFILFKLTNGYLVSHLRMEGKFFPYETATEPVKHTHVVITFTDQSTLHYNDVRKFGTMELRTNETIHTTPPLSLLAYEPFDERVTTEALHRRLERMKTRAIKTALLDQSIFVGLGNIYVDETLFRAGVHPTRPAASLSREEVDRVRTEAVAVLNEAIERGGSTIRSYADPDGATGTFQERLYVYGQTGEPCRRCGHEIEKMKLGGRGTHYCPHCQQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: OEP39_ARATH
Sequence: MGAQKSIHAGRAKIDVNVDFTHKLCTSLMFPAFRDTSSPLSLVIGSLCIKHPNLFGGSEKLDVSWDKGLYDSNVLVAFRRPRPEWRPQQCFFIQHSLSPEIGVHGTPVDNFSRSGSGGVNLSKLALGLDLSEPASSKWSSTTSIKFEHVRPINDDGRAITRDLDGFPITCSGNTHDSMVVLKQESRFAKATDQGLSHFSMQIEQGIPVVSKWLIFNRFKFVASKGVRFGPAFLLASLTGGSIVGDMAPYQAFAIGGLGSVRGYGEGAVGSGRSCLVANTELALPLNKMTEGTIFLDCGTDLGSSRLVPGNPSMRQGKPGFGYGFGYGLRFKSPLGHLQVDYAINAFNQKTLYFGVTNLASST
What is the function of this protein?
Beta-barrel pore-forming protein which possesses voltage-dependent channel activity (PubMed:25401771).  Required for proper plastid development (PubMed:29758131).  Involved in the maintenance of metabolic homeostasis of full-grown plants (PubMed:29758131).
What are the official names of this protein?
Outer envelope protein 39, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the OEP80 (TC 1.B.33.2) family.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane.
Protein: CMOB_SHISS
Sequence: MIDFGNFYSLIAKNHLSHWLETLPAQIANWQREQQHGLFKQWSNAVEFLPEIKPYRLDLLHSVTAESEEPLSTGQIKRIETLMRNLMPWRKGPFSLYGVNIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFSMGVLYHRRSPLEHLWQLKDQLVNEGELVLETLVIDGDENTVLVPGDRYAQMRNVYFIPSALALKNWLKKCGFVDIRIVDVCVTTTEEQRRTEWMVTESLSDFLDPHDPSKTVEGYPAPKRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: NCAP_EBOSB
Sequence: MDKRVRGSWALGGQSEVDLDYHKILTAGLSVQQGIVRQRVIPVYVVNDLEGICQHIIQAFEAGVDFQDNADSFLLLLCLHHAYQGDHRLFLKSDAVQYLEGHGFRFEVREKENVHRLDELLPNVTGGKNLRRTLAAMPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTSWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDTVISNSVAQARFSGLLIVKTVLDHILQKTDLGVRLHPLARTAKVKNEVSSFKAALGSLAKHGEYAPFARLLNLSGVNNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAETRELDNLGLDEQEKKILMSFHQKKNEISFQQTNAMVTLRKERLAKLTEAITTASKIKVGDRYPDDNDIPFPGPIYDDTHPNPSDDNPDDSRDTTIPGGVVDPYDDESNNYPDYEDSAEGTTGDLDLFNLDDDDDDSRPGPPDRGQNKERAARTYGLQDPTLDGAKKVPELTPGSHQPGNLHITKSGSNTNQPQGNMSSTLHSMTPIQEESEPDDQKDNDDESLTSLDSEGDEDGESISEENTPTVAPPAPVYKDTGVDTNQQNGPSSTVDSQGSESEALPINSKKSSALEETYYHLLKTQGPFEAINYYHLMSDEPIAFSTESGKEYIFPDSLEEAYPPWLSEKEALEKENRYLVIDGQQFLWPVMSLRDKFLAVLQHD
What is the function of this protein?
Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response.  VP35 binds to and stabilizes monomeric NP, keeping it soluble.  Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released.  The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication.  The nucleocapsid is helical with a pitch of 10. 81 NP per turn and a diameter of about 22nm.  Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid.  Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription.  Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the filoviruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: COAE_SYNS9
Sequence: MTFGDWPPQRRIGLTGGIASGKSSVAALLEKRGCPVLDADVYAREALATDTSASKAVVARYGKRVQKDGTSDIDRAELAAIVFNDPNERSWLEQLVHPIVQRRFDDALRSLPDAPIVILMIPLLFEAGLEKWCSEIWVVRCTALQQRERLMARNNCTEAEATQRIAAQWPIDIKVQRADSVINNSGRIDDLHDQLDALL
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PR39_PIG
Sequence: METQRASLCLGRWSLWLLLLGLVVPSASAQALSYREAVLRAVDRLNEQSSEANLYRLLELDQPPKADEDPGTPKPVSFTVKETVCPRPTRQPPELCDFKENGRVKQCVGTVTLNPSIHSLDISCNEIQSVRRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFPGKR
What is the function of this protein?
Exerts a potent antimicrobial activity against both E. coli and B. megaterium.
What are the official names of this protein?
Antibacterial protein PR-39.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: 4OT4_PSEPU
Sequence: MPFAQIYMIEGRTEAQKKAVIEKVSQALVEATGAPMANVRVWIQEVPKENWGIAGVSAKELGR
What is the function of this protein?
Catalyzes the ketonization of 2-hydroxymuconate stereoselectively to yield 2-oxo-3-hexenedioate.
What are the official names of this protein?
2-hydroxymuconate tautomerase, 4-oxalocrotonate tautomerase, 4-OT.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family.
Protein: KCY_STAAW
Sequence: MKAINIALDGPAAAGKSTIAKRVASELSMIYVDTGAMYRALTYKYLKLNKTEDFAKLVDQTTLDLTYKADKGQCVILDNEDVTDFLRNNDVTQHVSYVASKEPVRSFAVKKQKELAAEKGIVMDGRDIGTVVLPDADLKVYMIASVEERAERRYKDNQLRGIESNFEDLKRDIEARDQYDMNREISPLRKADDAVTLDTTGKSIEEVTDEILAMVSQIK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIA_RALSO
Sequence: MTQDELKALVAQAAADYVLANVPEGAVLGVGTGSTANLFIDAMAPHKARFAGAVSSSEASTRRLQGHGFAVLDLNEVDTIPVYVDGADEIDDTGAMIKGGGGALTREKIVASVAGRFVCIADGSKLVDVLGAFPLPVEVVPMARAAVARQLAALGGQPRLRMTKEGQIYQTDNGNVILDVSGLRIGEPKTLEAQINDIPGVVTVGLFAKRGADVLLLGTEAGVQRRDF
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: SEPF_STRMU
Sequence: MALRDSFNKIISYFDTDEVSEVEEPAVASVKRQQDAAQPASQQQKAQSHQYHQSASRPSQQQVQSGQNRRSGEENIHSLPTRRQSHNQQPAQEKTTIALKLPRKYEDAEEIVDLLIRNECVLIDFQYMLEAQARRCLDFIDGASKVLAGNLQKVGASMYLLTPINVIVDAEEMTLAANGQDVSFNYDMKRR
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: HELT_DANRE
Sequence: MNARALYKRPPPVSSSQSEASGKRRTRTLDALGFDNYIICNYRLVFYEMMASKMKDRKKTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQNSGKLEKAEILEMTVQYLRALHSADFPRGREKGELLTEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQSKVVTEPVFGSLGTISPDPTDLLCQLEYQSPSPTESVFQQSPPGHFSWHSSTRSPTLAYPAMSQHSGYLSPVQGLDHHYMNFIGHNAFSLHNAQHAAL
What is the function of this protein?
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'.
What are the official names of this protein?
Hairy and enhancer of split-related protein helt, HES/HEY-like transcription factor.
What is the protein family that this protein belongs to?
Belongs to the HEY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CO7_PONAB
Sequence: MKVISLFILVGFIGESQIFSSASSPVNCQWDSYTPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKRFYRLSGNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTTHTNEIHKGKSYQLLVVENTVEVTQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNGFTSVEEKKCKSSGWHFVVKFSSHGCKELENALKAASGTQNNVLRGNPFIRGGGAGFISSLSYLELDNPAGNKRRYSAWAKSVTDLPKVIKQKLTPLYELVKEVPCVSVKKLYLKRALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSSCVQGKKTRSRECNNPPPSGGGRSCIGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLQWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNAHCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECVPSLDVCARDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGACPLWGKCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGSLRCRGQSISVTSIRPCAAETQ
What is the function of this protein?
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.  C7 serves as a membrane anchor (By similarity).
What are the official names of this protein?
Complement component C7.
What is the protein family that this protein belongs to?
Belongs to the complement C6/C7/C8/C9 family.
What are the subcellular locations of this protein?
Secreted.
Protein: M3K8_RAT
Sequence: MEYMSTGSDEKEEIDLLINHLNVSEVLDIMENLYASEEPAVYEPSLMTMCPDSNQNKEHSESLLRSGQEVPWLSSVRYGTVEDLLAFANHISNTTKHFYRCRPQESGILLNMVISPQNGRYQIDSDVLLVPWKLTYRSIGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYLPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEALNPPREDQPRCQSLDSALFDRKRLLSRKELELPENIADSSCTGSTEESEVLRRQRSLYIDLGALAGYFNIVRGPPTLEYG
What is the function of this protein?
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses.  Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells.  Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production.  Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.  May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types.  In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis.  Plays a role in the cell cycle.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 8, Tumor progression locus 2, TPL-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.