PharMolix/UniProtQA huggingface dataset:
Protein: TYSY_ACIAD
Sequence: MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELLWFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSYKNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLYQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREPLPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO1C_HALMA
Sequence: MTAHDVSADIEAVVEDTELPRRLKDEVYSTIEERGVGVDDADRIAKAVETRYLDTRVDPLDPVGTVSAQSIGEPGTQMTMNTFHYAGVAEIDVTQGLPRLIELVDARKTPDTPMMTVHLDEEYATDRERAHEVVWKIEATRILALGDISTNVADMLVEIDLNEDTLLERWPTVNDTDAIAEEIAETIESNLGVSTRQAGTLIEFGPEEPSYRDLLQLVEELREIVFKGIEEITRVVIRKEETDNGEEFVLYTEGSDFGEVLDIEGVDASRTTCNNIHEIYRELGVEAARETLINETMNTLEEQGLDDVNVRHLMLVADIMTNEGTIESIGRHGISGSKDSVLARAAFEVTVNHLLDAAIHGEVDELDGVTENVIVGKPIKLGTGDVNLRMGTTQD
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PVK3_CRYDW
Sequence: GSSGLIAMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-3, CryDa-PVK-3.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: C1QT3_HUMAN
Sequence: MLWRQLIYWQLLALFFLPFCLCQDEYMESPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK
What are the official names of this protein?
Complement C1q tumor necrosis factor-related protein 3, Collagenous repeat-containing sequence 26 kDa protein, CORS26, Secretory protein CORS26.
What are the subcellular locations of this protein?
Secreted.
Protein: GCSH_NITMU
Sequence: MSIPNDLKYTKSHEWVRLEDDGTATIGITQHAQELLGDMVFVETPAVGRQLKQGDECAVVESVKAAADVYAPITGEVTAANPELASAPEKINQDAYAAWLFRLKPANTADLEKLLDSAGYQKLLESEDH
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: M21_BRSVA
Sequence: MSRRNPCKYEIRGHCLNGKKCHFSHNYFEWPPHALLVRQNFMLNKILKSMDRNNDTLSEISGAAELDRTEEYALGVIGVLESYLSSINNITKQSACVAMSKLLAEINNDDIKRLRNKEVPTSPKIRIYNTVISYIDSNKRNTKQTIHLLKRLPADVLKKTIKNTIDIHNEINGNNQGDINVDEQNE
What is the function of this protein?
Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription.  Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription.  Preferentially binds to poly(A)-rich sequences.  Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding.
What are the official names of this protein?
Protein M2-1, Envelope-associated 22 kDa protein, Transcription antitermination factor M2-1.
What is the protein family that this protein belongs to?
Belongs to the pneumoviridae M2-1 protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus. Note=Localizes in cytoplasmic inclusion bodies substructures called inclusion bodies associated granules (IBAGs). Forms a layer between the matrix and nucleocapsid.
Protein: NU2C2_PSINU
Sequence: MKEIESFLVYSSSILPECILIFSSIGILSIDLLSLPNEGDTFWSYSISLAALAISIIILLLQWNKEPVLTFSETFQISRFNDIFRFFLLICSFLCIPLSVDYIRCTKMPVTEFLLFVLTATLGGMFLCGANDLISIFVASECLALSSYLLSGYTKRDVRSNEAMMKYLLMGGASSSILVYGFSLPYGLSGGEIQLRGMVNGLINMQMYNSAGVSIAMIFILVGIGFKLSLVPFHQWTPDVYEGSPTPVVAFFSVTSKVAALALATRLFHILFSSLSNEWHLPLEILAILSMILGNLIAVTQTSMKRMLAYSSISQIGYILIGIIAGDSDNGYASMITYMLIYIFMNLGTFACITSFGLRTGTDNIRDYAGLYRKDPILTLSLVLCLLSLGGIPPLAGFFGKLYLFWCGWKAGLYFLVSIALFTSVISIYYYSRIIKLLFTERNKRITIYMQDYKGSPYFLIPNNSIGITMILCTIASTVPGILINPIIAIAQNTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RM41A_XENLA
Sequence: MGLISKIARGLVRGADRMAECTSKQGPNSYNKGRGAKKIGYLTASGKFVKVREMVPVFVVPDLTGFKLKPYVSYKAPPGTEDPMTAKKLFMETVGPQIEKDLQEGTFRPEDLEKYGFEPTQEGKLFKLFPRNYIQ
What is the function of this protein?
Component of the mitochondrial ribosome large subunit.  Also involved in apoptosis and cell cycle (By similarity).
What are the official names of this protein?
39S ribosomal protein L41-A, mitochondrial, L41mt-A, MRP-L41-A.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EDN1_BOVIN
Sequence: MDYFPMIFALLFVAFQGAPEAAVLGTELSAGAEDGGEKPAPATPWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPSRSKRSLKDFFPTKATVHRKRCQCASQTDKKCWNFCQAGKELRDQDSMEKAWNNQKRGKDCSKLGEKCLHQQLVAGRKTRRLEAISNSIKTSFRVAKLKAQLYRDKKVIYNRAH
What is the function of this protein?
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity).  Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
What are the official names of this protein?
Endothelin-1, ET-1, Preproendothelin-1, PPET1.
What is the protein family that this protein belongs to?
Belongs to the endothelin/sarafotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GET1_MAGO7
Sequence: MPSLLILIFTIEVAVELINTIGAATINNLLWRIFNALPTKLSAQFAEQRKLQQDYLKVRRELNATSSQDEFAKWAKLRRQHDKLLEQLEKKKAALDSTKGNFDKYITGIRWVGTQGLRYFLPFWYAKVPMFWLPYGWFPYYAEWLVSFPRAPMGSVSIASWQLACTGFVVLIKDAITALVVFVMGMRQSNVKQAVPVKAVSGEKASDEKEGKKEL
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
What are the official names of this protein?
Protein GET1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYC_THEMA
Sequence: MRITNTLTGKKEEFVPIQPGVVRMYVCGPTVYDLIHVGNARPALVFDVFRRYLEYRGYRVIMVQNFTDIDDKIINKANQLGVDYKTVADTFIAEYWRDAHALGIRPANFHPRTTDFVEDIVEIIEKLVEKGFAYQTETGVYFDVRKFEKYGELSKKKIEDLIAGARVEVDETKKSPLDFSLWKKAKPGEPCWKSPWGEGRPGWHIECTVMSVKILGESFDIHAGGEDLVFPHHENEKAQAEALTGKVFARYWMHNGMVRFLGDKMSKSTGNIFTVREAVKRYGRDGLRYMILSKHYRSPMDFSEELLQDYSRAVKRVWEILGRYEKSGDIGIPKRNAVYEEYVNRFVEALDDDFNTPVAVSLIFELARNLSKAMDDNDREDALLYYHLIRREFGPVLGLFDLNEEKKEVSSEELLKLLIEVRDVLRKEKRYDLSDRIRDRLREIGIILKDTPSGTEYTVE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_ECO7I
Sequence: MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRAVEGTPFECLKDAFVGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELIPASQIDRLATLPTYEEAIARLMATMKEASAGKLVRTLAAVRDAKEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: DER_CHLTA
Sequence: MRIAILGRPNVGKSSLFNRLCKRSLAIVNSQEGTTRDRLYGEIRAWDSIIHVIDTGGVDQESTDRFQKQIHQQALAAAEEASVLLLVVDIRCGITKQDEELAKRLLPLKKPLILVMNKADSQQDLQRIHEFYGLGISDMIATSASHDKHIDLLLERIRQIAQIPVPSVEEQDAVQEDELPSEEAAISLHAFADETLFENESLSQEEASFLEELVAQTATPAPVDRPLKVALIGHPNVGKSSIINALLKEERCITDNSPGTTRDNIDVAYTHNNKEYVFIDTAGLRKTKSIKNSVEWMSSSRTEKAISRTDICLLVIDATQQLSYQDKRILSMIARYKKPHVILVNKWDLMFGVRMEHYVQDLRKMDPYIGQARILCISAKQRRNLLQIFSAIDDVYTIATTKLSTSLVNKVLASAMQRHHPQVINGKRLRIYYAIHKTTTPFTFLLFINSNSLLTKPYELYLKNTLKAAFNLYRVPFDLEYKAKPARKSN
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: SURE_ECOHS
Sequence: MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFENGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLDGHKHYDTAAAVTCSILRALCKEPLRTGRILNINVPDLPLDQIKGIRVTRCGTRHPADQVIPQQDPRGNTLYWIGPPGGKCDAGPGTDFAAVDEGYVSITPLHVDLTAHSAQDVVSDWLNSVGVGTQW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNPC1_MACFA
Sequence: MGTPPGLQTDCEALLSRFQETDSVRFEAFTELWRNMKFGTIFCGRMRNLEKNMFTKEALALAWRYFLPPYTFQIRVGALYLLYGLYNTQLCQPKQKIRVALKDWDEVLKFQQDLVNAQHFDAAYIFRKLRLDRAFHFTAMPKLLSYRMKKKIHRAEVTEEFKDPSDRVMKLITSDVLEEMLNVHDHYQNMKRVISVDKSKPDKALSLIKDDFFDNIKNIVLEHQQWHKDRKNPSLKSKINDGEEKMEGNSQETERCERAESLAKIKSKAFSVVIQASKSRRHRQVKLDSSDCDSASGQGQVKATRKKEKKERLKPAGRKMSFRNKGNVQNIHKEDKPLSLSMPVITEEENESLSGTEFTASKKKRKH
What is the function of this protein?
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes.  Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes.  Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).
What are the official names of this protein?
snRNA-activating protein complex subunit 1, SNAPc subunit 1, Small nuclear RNA-activating complex polypeptide 1, snRNA-activating protein complex 43 kDa subunit, SNAPc 43 kDa subunit.
What are the subcellular locations of this protein?
Nucleus.
Protein: YONP_BACSU
Sequence: MQKDSEKVTYMFSNLIGFLETAIIEGTASQEENTLYEDYKLFGTIDKKSYTYKNLVHKYLKSDY
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YonP.
Protein: RTF2_HUMAN
Sequence: MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIMLNGTKEDVDVLKTRMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAPGPSKVKTGKPEEASLDSREKKTNLAPKSTAMNESSSGKAGKPPCGATKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF
What is the function of this protein?
Replication termination factor which is a component of the elongating replisome (Probable).  Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication.  Might function to facilitate fork pausing at replication fork barriers like the rDNA.  May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable).  Interacts with nascent DNA (PubMed:29290612).
What are the official names of this protein?
Replication termination factor 2, RTF2, Replication termination factor 2 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the rtf2 family.
What are the subcellular locations of this protein?
Chromosome. Note=Localizes at the replication fork.
Protein: PTH_RHOOB
Sequence: MSEDTALVVGLGNPGPQYEKTRHNVGFMVAGVLSARMGGKFSAHKKSGAEIVQGRLEGRPTILAKPRSFMNLSGSAVAGLARFFSVDPGNIVVIHDELDLDFGTIRLKQGGGEGGHNGLRSISQSLGTKDYLRTRVGIGRPPGRMDPASYVLKPFSSVERKELDLVCEESADAVELVLRLGLEAAQNRLH
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y586_STRPQ
Sequence: MKLAVITDSTATLPIDLKQDKAIFSLDIPVIIDDETYFEGRNLSIDDFYQKMADSKNLPKTSQPSLSELDNLLGLLSSKGYTHVIGLFLAGGISGFWQNIQFLAEEHPEIEMAFPDSKITSAPLGSMVKNVLDWSRQGMTFQAILNKLQEQIDGTTAFIMVDDLNHLVKGGRLSNGSALLGNLLSIKPILRFDEEGKIVVYEKVRTEKKAMKRLVEILNDLIADGQYNVSIIHSKAQDKADYLKRLLQDSGYQYDIEEVHFGAVIATHLGEGAIAFGVTPRL
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein SPs1267.
Protein: BIOD_BRADU
Sequence: MNKRIVVTGTDTGVGKTVFSAGLAGLLGANYWKPVQAGLEQEIDSECIRRLGGLSSDRIVPELYRLRTPASPHHSAEIDGVRIDTETLGLPDSGERRLVIEGAGGLMVPLTARTLYIDIFERWQLPVVLCARTGLGTINHSLLSIEALRKRQIRILGIAFIGERNAETESAVCEIGRVRWLGRLPWLVPLTNDRLQAAFKDSFVSSDFLNL
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDA1_CAEEL
Sequence: MRFFHSIIVLLFSISTGSAFLLYGCNLSENLCDNDESCYPDGVFGQCYSSESGSPEPTVLDNLDDTQLELLKLELTRLAAKDKDWGDEETQCVLAYFKMSMFYQLQYDPDFCQVRKPANVWALIQLIDTGLTEDPTILDEDVNPENVTDEDMAQIIEQLKEPSLPTEEDIEEALNAQNEDVDDEILDQYVQAVVNNENPDFSELSDGQLNILIGRLVDLKKNVENEEAQLLTGDGEQEMAVPLDDLEERGEQAILKKDIEQVGEINQGLDNTEHKIVKGRKDQVVTRVDANRVYLKVHLKNEDQLMPLIEFLQNTIAIPNNLYFDDFQFENGQLSMRISRFEGAKPKADKRIDSVEGVASAVYKRRKDIARLSGADVRETGIGSGEDGSLPVESSERDWLLMPVLFVCAFTVTALGLVAAVQIARSRRHYKDNIQQIAEQLDGKNSFAYQDLCRQRADGGRASKSSSTSSWCEETAVPTIDISTGHVVLNFLQEYLSEPTKIEAQWNGIKDYRNEERTKTKAEKFASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEKNYWPDTGSEVHGAFEIHLVSEHIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLLKSIATK
What is the function of this protein?
Regulates dense-core vesicle (DCV) trafficking and/or secretion (PubMed:19343207).  Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord (PubMed:27116976).  Involved in locomotion by regulating acetylcholine release (PubMed:15044551).  Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior (PubMed:17611271).  Plays a role in preventing dauer formation (PubMed:15044551).
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase-like ida-1, Dense-core vesicle membrane protein ida-1, Related to islet cell diabetic autoantigen protein.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, axon. Cell projection, dendrite. Note=Localizes to dense-core vesicles along axons.
Protein: DEF_CAUVC
Sequence: MAIRRILTVDNAADLATLKKISTPVEAVTDELRALMDDMLETMYDAPGIGLAAVQVGEPVRVIVMDLAREGEDKAPRYFVNPEILASSEDLQGYEEGCLSVPEYYDEVERPSKVTLRYMNYQGETVVEEAEGLFAVCIQHEMDHLEGVLFIDHLSRLRRDRAMAKVKKARRAA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: CC134_MOUSE
Sequence: MDLLQFLAAFSVLLWPGTEVTGALKSTLDPSLKIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLIAADVLPDGPVPQDEKLKDAFSHVVENTAFFGDVVLRFPKIVHHYFDHNSNWNLLIRWGISFCNQTGVFDQGPHSPILSLMAQELGITEKDSDFRNPFKTDQTEFIPSTDPFQKALREEEKRRKKEERRKEIRKGPRISRSQSEL
What is the function of this protein?
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity.  May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity.  May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
What are the official names of this protein?
Coiled-coil domain-containing protein 134.
What is the protein family that this protein belongs to?
Belongs to the CCDC134 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum. Note=Accumulates in the nucleus in response to UV irradiation.
Protein: NTAQ1_DROSE
Sequence: MTTDFLFPKIADCSYVSCYCEENVWKLCEQVKRTRPEELSKCYAVFVSNEGRTVPLWRQKAGRGDDQVVIWDYHVFFIHNPLLNRCLVFDLDTTLPFPTYFHKYVTETFRSDLALRPEHHRFFRVIPADTYLIEFSSDRRHMRRPDGSWIKPPPSYPPILSNSNMHCLGDFICMSAGKGPGAVYSLSEFVQNFYKSPHVMAQNNK
What is the function of this protein?
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation.  Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.  Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
What are the official names of this protein?
Protein N-terminal glutamine amidohydrolase, Protein NH2-terminal glutamine deamidase, N-terminal Gln amidase, Nt(Q)-amidase, Protein tungus.
What is the protein family that this protein belongs to?
Belongs to the NTAQ1 family.
Protein: GRPE_LISW6
Sequence: MSEKKNKKERLADEIEQEELNILDESEETVEEEATADALTEEQAKILELENKLDEVENRYLRMQADFENVKKRHIADRDASQKYRSQSLAEDLLPALDSFEKALATTSDQEEVKQILKGMEMVYNQILVAFEKEGIEVIPAVGEQFDPNFHQAVMQDSDENAASNEITAELQKGYKLKDRVIRPSMVKVNQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYOC_SHIFL
Sequence: MATDTLTHATAHAHEHGHHDAGGTKIFGFWIYLMSDCILFSILFATYAVLVNGTAGGPTGKDIFELPFVLVETFLLLFSSITYGMAAIAMYKNNKSQVISWLALTWLFGAGFIGMEIYEFHHLIVNGMGPDRSGFLSAFFALVGTHGLHVTSGLIWMAVLMVQIARRGLTSTNRTRIMCLSLFWHFLDVVWICVFTVVYLMGAM
What is the function of this protein?
Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at high aeration.  Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity).
What are the official names of this protein?
Cytochrome bo(3) ubiquinol oxidase subunit 3, Cytochrome o ubiquinol oxidase subunit 3, Cytochrome o subunit 3, Oxidase bo(3) subunit 3, Ubiquinol oxidase chain C, Ubiquinol oxidase polypeptide III, Ubiquinol oxidase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.