PharMolix/UniProtQA huggingface dataset:
Protein: NNAT_RAT
Sequence: MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAHTVSRTGRQVLGERRHRAPN
What is the function of this protein?
May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system.
What are the official names of this protein?
Neuronatin.
What is the protein family that this protein belongs to?
Belongs to the neuronatin family.
Protein: LIPF_MYCTO
Sequence: MSSYYARRPLQSSGCSNSDSCWDGAPIEITESGPSVAGRLAALASRMTIKPLMTVGSYLSPLPLPLGFVDFACRVWRPGQGTVRTTINLPNATAQLVRAPGVRAADGAGRVVLYLHGGAFVMCGPNSHSRIVNALSGFAESPVLIVDYRLIPKHSLGMALDDCHDAYQWLRARGYRPEQIVLAGDSAGGYLALALAQRLQCDDEKPAAIVAISPLLQLAKGPKQDHPNIGTDAMFPARAFDALAAWVRAAAAKNMVDGRPEDLYEPLDHIESSLPPTLIHVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQAHLFQLATPLVPEATRSLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSPI
What is the function of this protein?
A short-chain esterase and phospholipase.
What are the official names of this protein?
Carboxylesterase/phospholipase LipF.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
Protein: EPD_CLUHA
Sequence: MRLTGLLCVALWSASAVVLAEHQPCRPPPQTHGNLWVTAAKGAPASVGEFNYDSQARKLHFKDDALHVNKTDHLEMLIFFEEGIFYDIDSHNQSCHKKTLQSTYHCLEVPPNATHVTEGYLGSEFIGDQGVRMRKWRKRVPELDGVVTVATTSCGCVTLFATLFTDSNDVLVFNFLDVEMKVKNPLEVFVPPSYCDGVALEEEGDTFFGLFH
What is the function of this protein?
May play a role in neural plasticity.  May be involved during axon regeneration.
What are the official names of this protein?
Ependymin, EPD.
What is the protein family that this protein belongs to?
Belongs to the ependymin family.
What are the subcellular locations of this protein?
Secreted.
Protein: VATB_CLOBJ
Sequence: MLKEYRTVKEVVGPLMLVDQVESVSFDELVEIELHNGEKRRGRVLEINKDKALVQLFEGSAGINIKGAKVKFLGKPLELGVSEDMLGRVFDGLGNPKDGGPKIIADEKRDISGIPINPVARNYPDEFIQTGVSAIDGLNTLVRGQKLPVFSGSGLPHAELAAQIARQAKVLKSDSKFAVVFAAIGTTFEEAQYFIDDFTKTGAIDRAVLFINLANDPAIERIATPRMALTAAEYLAFEKGMHVLVIMTDITNYCEALREVSAARKEVPGRRGYPGYLYTDLSTIYERAGRILGKEGSITQIPILTMPEDDKTHPIPDLTGYITEGQIILSRELYKKGIMPPIDVLPSLSRLKDKGIGKEKTREDHADTMNQLFAAYAQGKQAKELSVILGESALSDTDKLYAKFADAFEEEYVSQGFTTNRTIEETLNLGWKLLTILPKSELKRIRDEYLEKYLNKAEESK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: RIMP_LEPBA
Sequence: MVYTEENIRELILRVLAPPLALFSLQVQNRKNHALIEIELDHLTDKTGSASLEDCETVSRRLKEELDQWGEEFDFTLQVSSAGAERVLRLPEDLIRFQGLLVKLEVPLESGKWDKRLYRLGPVSGDSVELTLYDRKTRHKKNQKSVSMPIAEIRKGNLYLEI
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SKP_BLOFL
Sequence: MKNRVYMLGIIIWLAQINYVNAANKIVVMNVANIFQQSAQRTEIIKQLEYEFKDRAAELEMMEHDLQTKMQTLQRDGATMTASDRNTLEKSLIAQRELFSNKAKLFQQENHARQTEERDKILDMIYKIVKNIAKKENYDIVIDTNAVVYFSSHIKDITDSVSNQMRVK
What is the function of this protein?
Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.
What are the official names of this protein?
Chaperone protein Skp.
What is the protein family that this protein belongs to?
Belongs to the Skp family.
What are the subcellular locations of this protein?
Periplasm.
Protein: EQXC_FUSHE
Sequence: MVQRQQTALVGTHDGGIRLSSTETIPDIAGDSVLIKTKAVSVNPVDTKMIGPYVTPGAVAGFDFAGVVEMVGPDATKCDIRVGDRVCTAIMGMNPLDPTVGAFAEYTAAVEWILLKIPPSLSFQEGASLGISFMTTGLALFKSLGLPGNPLSPATEKLPVLVYGGSSATGTAAIQLVRLAGFAPITTCSPRNFELVKSYGASAVFDYNDPNCISDIKKHTKNNIRYALDCISTTQSMQFCYQAIGRAGGKYTALEPYSEAVARTRKMVKPDWIMGPQMLGKEIRWPEPHWRPANAEMGEFGVYWTAVLNKLLENDLIRPHAIVVREGGLEKVLDGIEDIRAKKISGKKLVFTL
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of equisetin, a trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:23614392).  The PKS module of eqxS together with the enoylreductase eqxC catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the eqxS NRPS module (PubMed:23614392).  Activity of the Dieckmann cyclase domain (RED) results in release of the Dieckmann product intermediate (PubMed:23614392, PubMed:18652469).  Diels-Alderase eqx3 is involved in endo-selective Diels-Alder cycloaddition to form the decalin ring, leading to the production of N-desmethylequisetin also called trichosetin (By similarity).  Subsequent N-methylation is carried out by eqxD to give equisetin (PubMed:23614392).
What are the official names of this protein?
Trans-enoyl reductase eqxC, Equisetin biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: GRPE_DEIRA
Sequence: MFTNPFGRKKDMSDDQKKNNQPDTEADNAENIKFAADDTELRAGDETDADFEMPEGFPEMDENMFGQVQEMMAKLERVDELEKENADLKNRLGRLASDFEGYRNRTTIESAEAHDKGVSKAAEALMPVYDDIDRALSLSVDDAAKLVPGMQAVQNKVLTIFGTLGLEATGREGEQFDPQWHEAIQVVAGDEDEKIVQTYQLGFKMGDRLVRPARVVVSRKG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_CLOBJ
Sequence: MHIKTLTVSQLNRYVKNTLDADFILNNASVKGEISNLKIHSSGHIYFSLKDGGSKINCVMFKSYAYNLKFVPENGMDVVALGNVSVYEKEGSYQLYVKDMKREGIGDLYVAFEKLKEKLKEEGLFDDVHKKEIPKFSKKVGVITSPTGAALKDIINVTKRRNKGIELLIYPALVQGTDASRTLIEGIKILNKVEDVDIIILARGGGSIEELWAFNNEELAYAVYNSKKPIITGVGHETDFTIVDFVSDRRAPTPSAAAEIAVFDREVLINEILNYKYNIKNSMENIIKEKRSYLNLYKQKIEANSPTNIIVNEYKNIDNLKELLNMKIEGKLNKEKNNLSRLSSLLEAHNPLNVLKKGYTLIEDEGNNLITEKESLKKLNKINIIFKDGRAKLSIEYIEEF
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_ECO8A
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLAGVATNTAYLDGLMKPYLSRLLEELGQVEKAVLRIALYELSKRSDVPYKVAINEAIELAKSFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: NDK_MYCS2
Sequence: MTERTLVLIKPDGVKRQLVGEILSRIERKGLTLAALELKNVSDDLARQHYAEHADKPFFGSLLEFITSGPLVAAIVEGPRAVAAFRQIAGGTDPVEKAVPGTIRGDFALITQDNLVHGSDSPESAAREIALWFPGEATA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAR9_PACBA
Sequence: GRGGASNYVRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-9, FMRFa-9.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: METK_NEIMA
Sequence: MSEYLFTSESVSEGHPDKVADQVSDAILDAILAQDPKARVAAETLVNTGLCVLAGEITTTAQVDYIKVARETIKRIGYNSSELGFDANGCAVGVYYDQQSPDIAQGVNEGEGIDLNQGAGDQGLMFGYACDETPTLMPFAIYYSHRLMQRQSELRKDGRLPWLRPDAKAQLTVVYDSETGKVKRIDTVVLSTQHDPSVGYEELKNAVIEQIIKPVLPSELLTDETKYLINPTGRFVIGGPQGDCGLTGRKIIVDTYGGAAPHGGGAFSGKDPSKVDRSAAYACRYVAKNIVAAGLATQCQIQVSYAIGVAEPTSISIDTFGTGKISEEKLITLVREHFDLRPKGIVQMLDLLRPIYSKSAAYGHFGREEPEFTWERTDKAAALRAAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRDX4_DICDI
Sequence: MRSATKLFKNLSKSVVQLKTVKPVSSLNFGYIKTRQFSTSTTDSSNLFLNNNNQFQNFTFPTKQQIRIRKPAPAFKGQAVVNGEFKEISLDDYKGKYLYLFFYPLDFTFVCPTEIIAFSNAAEEFKKAGCELVGCSIDSPFTHLAWINTPRKEGGLGGINIPLLSDLTHQISKDYGVYIEEDGHTIRGSILIDKEGLVRVITMNDNPVGRSVDEAIRTLKALKFTDQFGEVCPANWSEGDKSMKADPKGSKEYFEAVNK
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.  Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
What are the official names of this protein?
Peroxiredoxin-4, Thioredoxin-dependent peroxiredoxin 4.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: ZIPA_PSEPW
Sequence: MEIGLREWLILIGIIVIAGILFDGWRRMRGGKGKLKFRLDRSYSNLPDEEGSAEVLGPSRVLDTQKEPELDESDLPSLSAPAREREREQKPAKATKRGKRAAEMQPQGDLDLVAEPREPDLFADADDDFAGDNNRNSGFAAAGSAAKELPPVEEVLVISVISRDEGGFKGPALLQNILESGLRFGEMDIFHRHESMAGHGEVLFSMANAVKPGIFDLDDIDHFSTRAVSFFLGLPGPRHPKQAFDVMVAAARKLAHELNGELKDDQRSVLTAQTIEHYRQRIVEFERRALTQKR
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: CH60_ACTSZ
Sequence: MAAKDVKFGNDARVKMLAGVNVLADAVKVTLGPKGRNVILDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVAAVVSELKALSKPCETSKEIEQVGTISANSDSIVGQLIAQAMEKVGKEGVITVEDGTGLEDELDVVEGMQFDRGYLSPYFINKPETATVEMDNPYILLVDKKISNIRELLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKAALEDLGQAKRVVINKDNTTIIDGVGDEAQIKGRVAQIRQQIEESTSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGIVAGGGVALIRAASKAAANLQGDNEEQNVGIKLALRAMEAPLRQIVANAGEEASVVASAVKNGEGNYGYNAGTEEYGDMIAMGILDPTKVTRSALQFAASIAGLMITTEAMVTELPKDDKLDPSAAMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_HAHCH
Sequence: MIGNARMSQKYPTSSSRKRSPLSSGKYSAIGLLAYCRPGFEAECAQELQNIASLQFVYGYSKIDKGTGVVFWRCSQGNPLDVYKEIEVSRCIFARQVFCALHDIEIEDTTDRVSPVVEALRPGGAFGFLHIETPLEDEAGSLQKLAKKLTAPMSAALRNAGVLSKAKTDELPQLHLVCLSGQHIIAALAVHPNSSALPLGIPRLRFRNEAPSRSALKIEEAFLTMLTPAEREFVLKRGQRGVDLGAAPGGWTWYMVTQGVKMTAVDHGALQQELLEDPAVTYVSDDGYVYKPQRKVDWVVCDIVDKPKRTMERMADWLCYDWTTYALFNLKLPMKTRMDEVEACLQRLQERLLGADIESEVRVKQLYHDREEVTVLALTGHFLTAFQKH
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF1A2_DAUCA
Sequence: MGKEKIHISIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVLDKLKAERERGITIDIALWKFETTKYYCTVIDAPGHRDFIKNMITGTSQADCAVLIIDSTTGGFEAGISKDGQTREHALLAFTLGVKQMICCCNKMDATTPKYSKSRFEEIVKEVSSYLKKVGYNPDKIAFIPISGFEGDNMIDRSTNLDWYKGPTLLEALDQISEPKRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKPGMVVTFGPSGLTTEVKSVEMHHEALQEALPGDNVGFNVKNVAVKDLKRGYVASNSKDDPAKEAANFTAQVIIMNHPGQIGNGYAPVLDCHTSHIAVKFAEIQTKIDRRSGKELEKEPKFLKNGDAGFVKMIPTKPMVVETFMSYPPLGRFAVRDMRQTVAVGVIKSVEKKDPTGAKVTKAAIKKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HARB_PYRAB
Sequence: MAELPIAPVDRLIRKAGAQRVSEKAAKLLAEHLEEKALEIAKKAVDLAKHAGRKTVKVEDIKLAIRS
What is the function of this protein?
Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils.  Increases the resistance of DNA to thermal denaturation (in vitro).
What are the official names of this protein?
Archaeal histone B, Archaeal histone A2.
What is the protein family that this protein belongs to?
Belongs to the archaeal histone HMF family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: YFCN_SALG2
Sequence: MKKKTSLSEEDQALFRQLMVGTRKIKQDTIVHRPLRKKITEVPTRRLIQEQADASHYFSDEFQPLLNTEGPVKYVREDVSHFELKKMRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHIFCACVMHGHGKHILKQQTPLWLAQHPHVMAFHQAPKEYGGDAALLVLIEVEEWQPPELP
What are the official names of this protein?
UPF0115 protein YfcN.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: TBB2_ELEIN
Sequence: MREILHIQGGQCGNQIGAKFWEVVCDEHGIDPTGRYTGTSDLQLERVNVYYNEASCGRFVPRAVLMDLEPGTMDSVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPRGLSMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEDGEYEDELDGQEEEDM
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-2 chain, Beta-2-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: BX8_MAIZE
Sequence: MAASCGGRVVVFPFPFQGHFNPVMRLARALHARGVGITVFHTAGARAPDPADYPADYRFVPVPVEVAPELMASEDIAAIVTALNAACEAPFRDRLSALLSAADGEAGEAGGRVRCVLTDVSWDAVLSAARGLGVPALGVMTASAATFRVYMAYRTLVDKGYLPVREERKDDAVAELPPYRVKDLLRHETCDLEEFADLLGRVIAAARLSSGLIFHTFPFIEAGTLGEIRDDMSVPVYAVAPLNKLVPAATASLHGEVQADRGCLRWLDAQRARSVLYVSFGSMAAMDPHEFVELAWGLADAGRPFVWVVRPNLIRGFESGALPDGVEDRVRGRGVVVSWAPQEEVLAHPAVGGFFTHCGWNSTVEAVSEGVPMICHPRHGDQYGNARYVCHVWKVGTEVAGDQLERGEIKAAIDRLMGGSEEGEGIRKRMNELKIAADKGIDESAGSDLTNLVHLINSY
What is the function of this protein?
Glucosyltransferase involved in the last step of benzoxazinoid glucoside biosynthesis.  Catalyzes the glucosylation of hydroxamic acids utilizing UDP-glucose as glucose doner, reducing the toxicity of these natural insecticides for storage.  Can use DIMBOA and DIBOA as substrates, HMBOA (2-hydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) and HBOA (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one) with a lower efficiency, but not indole acetic acid or quercitin.
What are the official names of this protein?
DIMBOA UDP-glucosyltransferase BX8, 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase BX8, Protein BENZOXAZINLESS 8.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: HIS6_NITHX
Sequence: MFKVRVIPCLDVKDGRVVKGVNFVDLRDAGDPVEAAVAYDAAGADELTFLDITATHENRGIMLDVVRRTAEACFMPVTVGGGVRTIDDIRTLLRSGADKVSINSAAVSRREFVKEAAEKFGDQCIVVAIDAKRVSRAGGSDRWEIFTHGGRKSTGIDAIDYAQEVVSLGAGEILLTSMDRDGTRQGFDLPLTRLVADSVSVPVIASGGVGNLDHLVDGIREGHATAVLAASIFHFGEFTIRQAKDHMARAGLPMRLDP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PREP_XENTR
Sequence: MIRQCRAGLRLCRALYQTSYRWHGKSACERALRYAPGESIHGFTVNEVTPVPELFLTAVKLSHDNTGAKYLHVAREDSNNLFSVQFRTTPLDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTMYPFSTQNAKDFQNLLSVYLDAVFFPCLRELDFWQEGWRLEHENPEDPNSPLIFKGIVFNEMKGAFTDNEKVFSQHLQNKLLPDHTYSVVSGGEPLNIPDLTWEQLKQFHATHYHPSNARFFTYGNLPLEIHLKQIHEDALSKFERIDPKTSVPPQERWQSPREYSISCGTDSFASDPEKQTTVSVNFLLSEITDTFEAFTLSLLSSLMVDGPNSPFYKALIEANLGTDFSPDTGFNNYTRETYFSIGLQGINKEDSEKVKAIINKTINEVAEHGIEAERIEALLHKLEIQMKHQSTSFGLTLASYVASCWNHEGDPVDLLKIGDKISRFRECLKENPKFLQDKVKQYFQVSQHRMTLSMSPDEQHYDKEAQLEAEKLTQKVKALSEEERKQIYEKGLELIRLQSKPQDASCLPALKVSDIEPKIPLTDLDITYAGDVPVQYCAQPTNGMVYFRAVSSLNTLPEELKPYVPLFCSVITKLGCGVYNYREQAQQMELTTGGMSVCPHIITDDSNLDTYEQGVVFSSLCLDRNLPDMMHLWSEIFNSPHFDDEERLRVLVRMSAQEMSNGIPDSGHVYASIRAGRTLTPAGELQELFSGMDQVKMIKRIAEMPEMGPILRKLSRIRKYVLLSDNMRCSVNATPQQMPVASKEIEHFLAGISRSKKERKSIRPHVVEKSSSPSSSGSEISRRATRKLVGDPTFKPCQMKTHFSLSFPVNYIGECVRTVPYTHPDYASLRILARIMTAKFLHGEIREKGGAYGGGAKLSFDGIFGFYSYRDPNSLSTLSTFQKAADWAKSGQFTQQDVDEAKLSVFSAVDSPIAPSDKGMNHFLHGISDEMKQKHREQLFAVTHSDLTNASNKYLTAGQCTRGTAILGPENRNIAKDPSWIIR
What is the function of this protein?
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing.  Has an ATP-independent activity.  Specifically cleaves peptides in the range of 5 to 65 residues.  Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.  Degrades the transit peptides of mitochondrial proteins after their cleavage.  Also degrades other unstructured peptides.
What are the official names of this protein?
Presequence protease, mitochondrial, Pitrilysin metalloproteinase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family. PreP subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PIM1_MOUSE
Sequence: MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSDFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEDLARGFFWQVLEAVRHCHNCGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPSDRPSFEEIRNHPWMQGDLLPQAASEIHLHSLSPGSSK
What is the function of this protein?
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis.  Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3).  Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity.  The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.  Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1.  Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis.  Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C.  Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability.  Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels.  Phosphorylation of CDKN1B, induces 14-3-3 binding, nuclear export and proteasome-dependent degradation.  May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3.  Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (By similarity).  Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (By similarity).  Promotes brown adipocyte differentiation (PubMed:27923061).
What are the official names of this protein?
Serine/threonine-protein kinase pim-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane. Note=Mainly located in the cytoplasm.