PharMolix/UniProtQA huggingface dataset:
Protein: OBG_THEP1
Sequence: MNIERADFVDRVKIFVKAGDGGNGCVSFRREKYVPKGGPDGGDGGDGGFVFLRANPSVSTLIEFVNKRKFVAENGKHGMGKKMKGRNGKDLFIDVPVGTVVKDAVTGEIIADLNEPGKIVCVARGGKGGRGNAHFATSTKQAPLIAERGEKGESRWLELELKILADVGLVGYPNVGKSSLISRISNARPKIANYPFTTLIPNLGVVKYDDFSFVVADIPGLIEGASEGVGLGNVFLRHVERCYLIAHVIDVSGYEREDPVRDYFVIREEMKKYSPFLLEKPEIVVANKIDLIGKEELEKILKRLRDATDREVIPVSAVTGEGIDLLVSKLASIVREMKVEKPERKEERFVKPSPVWRRLPEKFHLEVVKEDEGYWVVEGENLRVWIERFDLNQRDARLMLLQVLEKNGLNNKLKEAGVKEGDVVRIGDFEFEYRE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y542_GLOVI
Sequence: MKLAYFDCPAGISGDMCLGALVDAGVPADYLIAQLAKLPMHDEYRLHFERVVKNGVAATKARVPLGERAGHTHRHLPEIRALLETASLPPRAAEWSVRVFVALAHAEALVHNTTPERVHFHEVGATDALVDVVGTCLGLDYLNIEALHCSALPVGGGLVHAAHGVMPVPTPAVVRLWESRRVPVYSNRIHRELVTPTGAAIACALAASFGEMPSMAVLRVGLGAGDMDLPIPNILRLWLGEATEPLLAARARTVTDVHAHAHHDHSHEEVVACLETQTDDLNPQISGYLFERLLAAGAADVFTVPVGMKKSRPGTLMTVLCAPHLLSTCEEILLRETTTLGVRRHFQVRSVLERHHEPVETIFGTVRIKVGSRDQQVLNAQPEFEDCRRLSEQTGQPLKLVQQVALATWHQRRPTQSERQN
What are the official names of this protein?
Putative nickel insertion protein.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: SECY_MYCGE
Sequence: MQTVSSPKQKLNFGQRLLTLLQNRDFMVSLVLTVVLLILFRVLAIIPLPGIRINESVLDRNSNDFFSLFNLLGGGGLNQLSLFAVGISPYISAQIIMQLLSTDLIPPLSKLVNSGEVGRRKIEMITRIITLPFALVQAFAVIQIATNAGTGSSPISLANSGSEFIAFYIIAMTAGTYMAVFLGDTISKKGVGNGITLLILSGILSQLPQGFIAAYNVLSGIVITLTPQLTAAISFFIYFLAFLVLLFATTFITQATRKIPIQQSGQGLVSEVKTLPYLPIKVNAAGVIPVIFASSIMSIPVTIAQFQPQTESRWFVEDYLSLSTPVGIFLYAVLVILFSFFYSYIQINPERLAKNFEKSGRFIPGIRPGNDTEKHIARVLIRINFIGAPFLTVIAIIPYIVSYFIRLPNSLSLGGTGIIIIVTAVVEFISALRSAATATNYQQLRRNLAIEVQQTAKQDSLEQLQKEAPGIGNLW
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ZCHC2_HUMAN
Sequence: MLRMKLPLKPTHPAEPPPEAEEPEADARPGAKAPSRRRRDCRPPPPPPPPAGPSRGPLPPPPPPRGLGPPVAGGAAAGAGMPGGGGGPSAALREQERVYEWFGLVLGSAQRLEFMCGLLDLCNPLELRFLGSCLEDLARKDYHYLRDSEAKANGLSDPGPLADFREPAVRSRLIVYLALLGSENREAAGRLHRLLPQVDSVLKSLRAARGEGSRGGAEDERGEDGDGEQDAEKDGSGPEGGIVEPRVGGGLGSRAQEELLLLFTMASLHPAFSFHQRVTLREHLERLRAALRGGPEDAEVEVEPCKFAGPRAQNNSAHGDYMQNNESSLIEQAPIPQDGLTVAPHRAQREAVHIEKIMLKGVQRKRADKYWEYTFKVNWSDLSVTTVTKTHQELQEFLLKLPKELSSETFDKTILRALNQGSLKREERRHPDLEPILRQLFSSSSQAFLQSQKVHSFFQSISSDSLHSINNLQSSLKTSKILEHLKEDSSEASSQEEDVLQHAIIHKKHTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIVDWRKQSCTTIQHPEHCVTSADQHSAEKRSLSSINKKKGKPQTEKEKIKKTDNRLNSRINGIRLSTPQHAHGGTVKDVNLDIGSGHDTCGETSSESYSSPSSPRHDGRESFESEEEKDRDTDSNSEDSGNPSTTRFTGYGSVNQTVTVKPPVQIASLGNENGNLLEDPLNSPKYQHISFMPTLHCVMHNGAQKSEVVVPAPKPADGKTIGMLVPSPVAISAIRESANSTPVGILGPTACTGESEKHLELLASPLPIPSTFLPHSSTPALHLTVQRLKLPPPQGSSESCTVNIPQQPPGSLSIASPNTAFIPIHNPGSFPGSPVATTDPITKSASQVVGLNQMVPQIEGNTGTVPQPTNVKVVLPAAGLSAAQPPASYPLPGSPLAAGVLPSQNSSVLSTAATSPQPASAGISQAQATVPPAVPTHTPGPAPSPSPALTHSTAQSDSTSYISAVGNTNANGTVVPPQQMGSGPCGSCGRRCSCGTNGNLQLNSYYYPNPMPGPMYRVPSFFTLPSICNGSYLNQAHQSNGNQLPFFLPQTPYANGLVHDPVMGSQANYGMQQMAGFGRFYPVYPAPNVVANTSGSGPKKNGNVSCYNCGVSGHYAQDCKQSSMEANQQGTYRLRYAPPLPPSNDTLDSAD
What are the official names of this protein?
Zinc finger CCHC domain-containing protein 2.
Protein: RNH2_LEGPA
Sequence: MNTELKILMAGVDEVGRGPLAGAVVTAAVILKKPIDGLTDSKKLSPKQRNLLAIRIKEEALAFAYGRAEVEEIDQLNIHHATLLAMRRAVEALPIQPDNVVVDGAFTPQLNIPCKAIVQGDSLIPEISAASILAKVLRDEEMVALDKIYPGYGFAEHKGYATPVHKEALMRLGPCKIHRRSYSPVADLISK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPAST_CAEBR
Sequence: MFAFSKAPAGCSTYERVTQKFQDGSNKLRAAIEMDELTKQNGTINEKLQTAELYKQARQMLKEANEFNIMDIPESKRSEVREKREKTLNLEKSAQDRLIKICNEVDPNMKRASTAADPCRAARITPRNTRATVPGDKKVSKVKQTEKAPHVCSRGDRCGAHQPPPEKKSTPLKPVNQIRTRVKENKNPIGVQQQVFSFILSCCMRRNCRRPHYLFPCMISLKMNYFKFQATLPNQLNTVNRSNLLKGVDKAIGERLLDEILDSTGVRMDDVAGCHSAKATLEEAVILPALNPNLFSGLRQPVKGILLFGPPGNGKTLLAKAVAGESKQMFFNISASSLTSKWVGDSEKTIRGLFQIARNGQPSIIFIDEIDSILCERSEKDAEVSRRMKTEFLVQFDGATSSPDDRILVIGATNRPYELDDAVLRRFPKRIMLNLPDTEARKELITNTLKKHDMMDGLSSSDIRYIASNTSGFSNSDLVALCKEAAMVPVREIHRSKLSVTDGDKIRKIRASDFDTALRTIRPSTSDRILSKLSDFSRNFGC
What is the function of this protein?
Severs microtubules, probably in an ATP-dependent fashion.
What are the official names of this protein?
Probable spastin homolog spas-1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Spastin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Localized to the perinuclear region of the cytoplasm in early embryos. Present in the cytoskeletal fraction.
Protein: RS13_PROMT
Sequence: MARISGIDIPREKRVEVALTYIYGIGLTRAQSILEKSGVNPDIRVKDLEDSDIQKLRAVTEEFTLEGDLRRQEGMALKRLQDIGCVRGRRHRMSLPVRGQRTRTNARTRRGARKTVAGRKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MDH_METSB
Sequence: MARSKIALIGAGQIGGTLAHLAALKELGDIVLFDIAEGTPQGKALDLAESGPVEGFNASLKGANSYADIAGADVIIVTAGVPRKPGMSRDDLLGINLKVMDAVGGGIKQYAPDAFVICITNPLDAMVWALQKSSGLAPAKIVGMAGVLDSARFRYFLSEEFKVSVEDVTAFVLGGHGDDMVPSLRYSTVAGIPLTDLVKLGWTTQERLDAIVERTRKGGGEIVNLLKTGSAFYAPAASAIAMAEAYLKDKRRVLPCAAQLSGQYGVDNLYVGVPVVIGANGVEKIVEVTLDESEKAMFAKSVESVRGLVEACKVINPALAG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: RS12_PROM3
Sequence: MPTIQQLIRTERQHLTRKTKSPALRACPERRGVCTRVYTSTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGTLDTAGVKDRSQSRSKYGAKASKQD
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: GLMM_JANMA
Sequence: MTRQYFGTDGVRGKVGTSPITPDFVMRLGYAAGTVLTKSRKASSRPVVLIGKDTRISGYMLEAALEAGFSAAGVDVMLAGPMPTPAIAYLTRALRLSAGVVISASHNPYEDNGIKFFSASGNKLPDAIELEIEAALNEPMSCVASEKLGRAKRLDDARGRYIEFCKSTFPNELDLRGTKLVVDCAHGAAYHIAPDVFHELGAEVIAIGNQPNGFNINEGYGATAPAALVEAVRANQAHLGIALDGDADRLLVVDAAGRVYNGDELLYIMVKDRMRVRPIEGAVGTLMTNMALEVAFKEMGVGFARANVGDRYVLEVLRERGWQVGGEGSGHMLCLDKHTTGDGIVSALQILSALKRSGLSLAELTQDIEMFPQTLINVKVEPGFDWKKNKELLAEKEAVEAELGDKGRVLIRASGTEPLIRVMVEAKDADIADKMARRIAAKLSK
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: PRDPP_METMA
Sequence: MISEVDMDDNFLGLRARDEFYSGKHIHRASQLILLDPENRILLQKRSPGKFWFPNRYTYSVSGTVADESYEACIAREMLEEIGISVPFRRLFKIPCIRENKGAYHTIFSGRCSEEAASLIRHDLEEATSIEWVELEELHRAVKAEPGNYTPALREGIIKIFKEGCEKYLF
What is the function of this protein?
Hydrolyzes homoallylic isopentenyl diphosphate (IPP), its allylic isomer dimethylallyl diphosphate (DMAPP) and short-chain prenyl diphosphates geranyl diphosphate (GPP) and farnesyl diphosphate (FPP) to their corresponding monophosphate forms with high activity.  The preferred substrate is IPP.  ADP, NADPH, Ap5A and thiamine diphosphate (TPP) are weakly hydrolyzed.  No hydrolysis with ATP, dNTPs, 8-OH-dGTP, NAD+, FAD or acetyl-CoA.  The likely physiological role of this enzyme is to provide a substrate dimethylallyl phosphate (DMAP) for prenylated flavin mononucleotide (prenyl-FMN) synthase MM_1871 involved in the biosynthesis of prenyl-FMN, a coenzyme required in the archaea-specific mevalonate pathway.
What are the official names of this protein?
Prenyl-diphosphate phosphatase, Nudix hydrolase MM_2582, Prenyl-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: WHIB2_MYCS2
Sequence: MSYESGDFDRVVRFDNRLLGSVSHAPHIDTGSTPTGAAGRPQLSLVPDSFDVAPEAEEDQWQERALCAQTDPEAFFPEKGGSTREAKRICQGCEVRDACLEYALAHDERFGIWGGLSERERRRLKRGII
What is the function of this protein?
Acts as a transcriptional regulator.  Probably redox-responsive.  The apo- but not holo-form probably binds DNA (By similarity).
What are the official names of this protein?
Transcriptional regulator WhiB2.
What is the protein family that this protein belongs to?
Belongs to the WhiB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPTA_METJA
Sequence: MNWRCDVQNFEPDVKISLTRVGVTNLKKLVRLKRTNKRPIILLSTFEVFVNLPSSQKGIHMSRNPEVIEGIIDEALELESYEMETICEEIVKRLFEKHEYATEAEVFMVSDFMTKEKSPISGKYSQEIHKIMGGAKGIKKDDEIELTKIVGAEVVGITACPCAQNLIKEICIKNLKEKGFSDEDIDKILDSVIFATHNQRGIGRIILEVPTGYDIEIMDIIEIIKKSMSAEIHGILKRADEAYVVEQSHKNPKFVEDCVREMAKRVVEKFKHLPDETKVLIRQINMESIHRHDAFAEKVATLGELRRELLSYE
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.  It is also able to utilize a variety of GTP analogs as substrates, including GDP, beta,gamma-methylene-GTP and GTP-[gamma-thio].
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RS7_STRPD
Sequence: MSRKNQAPKREVLPDPLYNSKIVTRLINRVMLDGKRGTAATIVYDAFSAIKEATGNDALEVFETAMDNIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLRWLVNASRARGEHTMKDRLAKEIMDAANNTGASVKKREDTHKMAEANRAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: GLAH_SHIB3
Sequence: MNALIAVQNNAVDSGQDYSGFTLIPSAQSPRLLELTFTEQTTKQFLEQVAEWPVQALEYKSFLRFRVGKILDDLCANQLQPLLLKPLLNRAEGALLINAVGIDDVAQADEMVKLATAVAHLIGRSNFDAMSGQYYARFVVKNVDNSDSYLRQPHRVMELHNDGTYVEEITDYVLMMKIDEQNMQGGNSLLLHLDDWEHLDHYFRHPLARRPMRFAAPPSKNVSKDVFHPVFDVDQQGRPVMRYIDQFVQPKDFEEGVWLSELSDAIETSKGILSVPVPVGKFLLINNLFWLHGRDRFTPHPDLRRELMRQRGYFAYATHHYQTHQ
What is the function of this protein?
Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG).  Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Glutarate 2-hydroxylase, G-2-H.
What is the protein family that this protein belongs to?
Belongs to the glutarate hydroxylase family.
Protein: HNRC1_HUMAN
Sequence: MASNVTNKMDPHSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIAGCSVHKGFAFVQYDKEKNARAAVAGEDGRMIASQVVDINLAAEPKVNRGNAGVKRSAAEMYGSSFDLDYGFQRDYYDGMYSFPARVPPPPPIALAVVPSKRQRLSGNTSRRGKSGFNSKSGKRGSSKSGKLKGDDLQAIKQELTQIKQKVDSLLENLEKIEKEQSKQEVEVKNAKSEEEQSSSSMKKDETHVKMESEGGAEDSAEEGDPLDDDVNEDQGDDQLELIKDDEKEAEEGEDDRDSTNGQDDS
What is the function of this protein?
May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein C-like 1, hnRNP C-like-1, hnRNP core protein C-like 1.
What is the protein family that this protein belongs to?
Belongs to the RRM HNRPC family. RALY subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Component of ribonucleosomes.
Protein: TBA_EUPVA
Sequence: MREVISVHIGQGGIQVGNACWELFCLEHGIQPDGQMPSDKTIGGGDDAFNTFFSETGAGKHVPRAVLVDLEPTVCDEIRTGTYRQLFHPEQIISGKEDAANNFARGHYTIGKEIVDLVLDRIRKLADNCTGLQGFIGFHSVGGGTGSGLGSLLLERLSVDYGKKSKLCFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAVYDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDITEFQTNLVPYPRIHFMLSSYGPVISAEKAYHEQLSVAEITNSSFEPASMMAKCDPRHGKYMACCMMFRGDVVPKDVNAAVATIKTKRTIQFVDWSPGFKVGINYQPPTVVPGGDLAKVMRAVCMISNSTAIAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGIETAEGEGEEEDMAQ
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: CCME_PASMU
Sequence: MTPRRKSRMTVILFVLLGISIASALVLYALRQNIDLFYTPTEVVYGKNEDATQKPSVGQRIRVGGMVVAGTVERDPKSLKVKFDLNDIGPSISVEYEGILPDLFREGQGIVAQGVLKTPTLLEATEVLAKHDENYVPPELDAQMQKVHKPMGVADLKGESERDRQEKAYQKTSMQEGQK
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: NUOH_XANOM
Sequence: MNELLLNLVDPLHQWFLGLGDGGVVLWSVLKILLIAVPVIVSVAFYVVWERKLIGWMHVRHGPMYVGMGIFQAFADVFKLLFKEILQPSSSHKAMFIIAPLLTLAPAFAAWSVVPFDAKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGVMIASGSVNLSQIVFAQAGNSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIVAGHMVEYSGGAFALFFLAEYANMILVSFLISIFFFGGWLSPIQGWVNADISPWIDWLWKGGWPWLLMKVFFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQKGV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: END4_CHLPM
Sequence: MKRVGAHVSIAGGVENAPLNATAIGAKAFALFTRNQRQWHSPPLQKASVDAFRRHCEAGGFDARHILPHDSYLINLGNPDPDKLERSRKAFIEEMERAETLGLVLLNFHPGSHLNAIGEEECLGLIADSINLAIKATDRVTAVIENTAGQGTNLGSRFEHLRAIIDRIEDRSRIGVCLDTCHLFASGYDLGTAEAAERTFEEFDRTVGMQYLKGMHLNDALRPLGSRLDRHACIGKGMIGIEGFRYIMQSPLFEEIPLILETPDSEGWKEEIELLYSLE
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: TF2H3_DICDI
Sequence: MNNEGSAVINEDDDTSLLVVILDCNVYSWGNREKSLQDAISGMNDDNDSSSRYNGSTTIGNNNNNNNNNNSNNNNNVNKRLINTSKNNYIGFNKFLEHFMVFINAYLMLNQENQLAIICSKIGESSFVFPQSNIDQYQQEQQELEQRQLNENGELLPTPNKTIQGQILAKLQKLDLEIKHDQTDILSSSFSASMSIALCYINRIKRETPTIKPRILVFNISPDVSSQYISVMNCIFSSQKQSIPVDSCILSQSDSTFLQQASHLTSGIYLKPQKQELLSQYLLTTFLLDTLSRKSLAYPTLKSVDYRASCFCHKRIVDIGYVCSVCLSIFCGHSSSCSTCGTKFSLKIDLRKQLNNNPTTTTSATSTVNNKS
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
What are the official names of this protein?
General transcription factor IIH subunit 3, TFIIH basal transcription factor complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the TFB4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PPNP_ECO55
Sequence: MLQSNEYFSGKVKSIGFSSSSTGRASVGVMVEGEYTFSTAEPEEMTVISGALNVLLPDATDWQVYEAGSVFNVPGHSEFHLQVAEPTSYLCRYL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: AATC_MOUSE
Sequence: MAPPSVFAQVPQAPPVLVFKLTADFRDDPDPRKVNLGVGAYRTDESQPWVLPVVRKVEQKIANDNSLNHEYLPILGLAEFRSCASRLVLGDNSLAIRENRVGGVQSLGGTGALRIGADFLGRWYNGTDNKNTPIYVSSPTWENHNAVFSAAGFKDIRPYCYWDAEKRGLDLQGFLNDLENAPEFSIFVLHACAHNPTGTDPTPEQWKQIAAVMQRRFLFPFFDSAYQGFASGDLEKDAWAIRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVGKESDSVLRVLSQMEKIVRITWSNPPAQGARIVAATLSDPELFKEWKGNVKTMADRILTMRSELRARLEALKTPGTWSHITEQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINMCGLTTKNLDYVATSIHEAVTKIQ
What is the function of this protein?
Biosynthesis of L-glutamate from L-aspartate or L-cysteine.  Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system.  Acts as a scavenger of glutamate in brain neuroprotection.  The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis.  Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide.  Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST).  Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
What are the official names of this protein?
Aspartate aminotransferase, cytoplasmic, cAspAT, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX17B_MYRGU
Sequence: MKLSCLSLALAIILVLAIVYSPHMEVKALADAEPDAIGFADAFGEADAEPKRRRGLKKIIGKVIKGTGKVAGEAAASAVADAAVSAAIDAVVGTTEEPEQ
What is the function of this protein?
May have antimicrobial properties, like most ant linear peptides.
What are the official names of this protein?
U-myrmeciitoxin(01)-Mg7b, MIITX(01)-Mg7b, U-MIITX(01)-Mg7b.
What is the protein family that this protein belongs to?
Belongs to the formicidae venom precursor-01 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMH_LEPBJ
Sequence: MEPVHYSVQGNNILQIFMENFHKEDPVLFLDGTAGEGGHSLLFLKGFPNSKVILCDRDPVMLSRALARLVDFKERVVSIQTNFSEIDSNLLSSHGINDSPQGILLDLGISTFHLFHSGRGFSFKEAEPLDMRLTPNIGINAEDVINTYSKDRLMHIFYTYGEERWSKKIAEVIVERRKQNLISYTSELADLISKIIPRKLWPPGRHPATRIFQALRIEVNQELTHIEKGLDSLLNLLRPEGVIQVISFHSLEDRIVKNSLRNYAKQNGFELLTKKPILPSEEETKENPASRSAKLRVLRKTKSADKKYKKENSKEE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_STAA1
Sequence: MTATWEKKEGNEGLLTVTVPAEKVNKALDQAFKKVVKQINVPGFRKGKVPRPIFEQRFGVEALYQDAIDILLPDAYGEAIDETDIKPVAQPEVSVTQIEKGKDFIFEATVTVEPEVKLGDYKGLEIEKQETELSDDELQEAIDHSLGHLAEMVVKEDGVVENGDTVNIDFSGSVDGEEFEGGQAEGYDLEIGSGSFIPGFEEQLEGMKVDEEKDVVVTFPEEYHAEELAGKEATFKTKVNEIKFKEVPELTDEIANELDAEANTVDEYKENLRKRLAEQKATDAENVEKEEAITKATDNTTIDIPEAMVNTELDRMVSEFAQRIQQQGLDLQTYFQISGQDETQLREQMKDDAEQRVKTNLTLTAIAEAEKIEATDEDIDKELEKMSKQFNISVEDIKNTLGNTDIIKNDVRIQKVIDLLRDNAKFVEGTKED
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.