PharMolix/UniProtQA huggingface dataset:
Protein: DLTA_STRP1
Sequence: MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAYIPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGIWTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTRLPIGYPKPDSPTYIIDEDGKELSSGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRLDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSYMMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRAXI_CHICK
Sequence: MAASSTFFSPSLFLCVLVLIDITLAVSLDTDMKLKSENNNHLQNQETWPQQPRSGHHHKHGLAKKGRVLALPVRGQPAGEEALRVGSGAPAMEELVPLGQPAALKQDKDKDVFLGFELPHAERENQSPGSERGKKQNREQRRHSRRDRLKHHRGKTAVGPSSLYKKPESFEQQFQNLQAEEATSPTPTVLPFTALDLVVSTEEPPVLPATSPRSQARLRQDGDVMPTLDMALFDWTDYEDLKPEMWPSAKKKEKRRSKSSNGGNETSSAEGEPCDHHLDCLPGSCCDLREHLCKPHNRGLNNKCYDDCMCTEGLRCYAKFHRNRRVTRRKGRCVEPESANGEQGSFINV
What is the function of this protein?
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures.  Acts as a chemorepulsive guidance protein for commissural axons during development.  Able to inhibit or repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro.  Binds directly to the neurites and growth cones.
What are the official names of this protein?
Draxin, Dorsal inhibitory axon guidance protein, Dorsal repulsive axon guidance protein.
What is the protein family that this protein belongs to?
Belongs to the draxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PATL_ASPCL
Sequence: MFSTFSANLEATDASRDGSATPVTAPRPKRSQVARACDWCRLNRIKCDDKQPCQNCQNRGGHCSNTKPLEATSLPAANREIQRLRNKVKDLQEQIRTAKQEAEIRAHAQAQIQASTGYATPPLSDTVNGSFSNSEQLSNTKEGWQGIPPAGNRAGVLYYGPMSSTYFVTRITTYLAQAMNQPLVDTKLEACVARFDARTPAHRPSRSDASPESQTEGTDDTEDLSRSQEEYFLNLLWQSFHCVYPIISEPDFRRYYESLWSNTSPEGTRKPSPLVDVLLAVCMQYGSTFLVRGDENHEAEDSSHSENANMPGHAFYQRAQRLLQSELEHPSIMVLQSHVYSIIYLYNISLLNTAHINLGVTLRIAHTLRLHLRPLDGTPPEVQELHRNIWWTLYRLDNQLSMTLGRPSLIQNSQVSCGLPGDSRDHIRLSGTVLLSGHEDISWLSFHVQCIKLIFAVQGVQAAFQLKCSQLLNGDEAKDIYGDPRMTETLAEFLGREMTAVHEWVQNVPQSLRNARKGAGEAFSTDRAALNLDLYSPLWLQRQRLLLELLYHHLLISTFRPFIRFPPTSSSLTPLADGHNISCLNHAMAITNILHQVLSETDVLRGWSPAFQYQWDAILCTLGFVLANPVCPPTPSARKSLQTAVRTLDLVGDHFPAAVNAAQVVREVNCRADRLVDTFRQSLTRRQGQRTSPFSPTGLQKMNPPASQLAFSSAAQTASIPVLSDPLPPSMSASSLELVRARTIHPVPSIEMMPSTSPTDLSPPLVTTAESHSAGLPAVSVDVIAGNEVHWMQASAMILDSWTDFTTNP
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:19383676).
What are the official names of this protein?
Patulin cluster transcription factor patL, Patulin synthesis protein L.
What are the subcellular locations of this protein?
Nucleus.
Protein: AGE1_CAEEL
Sequence: MSMGRSPSTTFRSRTGSHGARDLIAGHGRNSRRISQMHVNILHPQLQTMVEQWQMRERPSLETENGKGSLLLENEGVADIITMCPFGEVISVVFPWFLANVRTSLEIKLSDFKHQLFELIAPMKWGTYSVKPQDYVFRQLNNFGEIEVIFNDDQPLSKLELHGTFPMLFLYQPDGINRDKELMSDISHCLGYSLDKLEESLDEELRQFRASLWARTKKTCLTRGLEGTSHYAFPEEQYLCVGESCPKDLESKVKAAKLSYQMFWRKRKAEINGVCEKMMKIQIEFNPNETPKSLLHTFLYEMRKLDVYDTDDPADEGWFLQLAGRTTFVTNPDVKLTSYDGVRSELESYRCPGFVVRRQSLVLKDYCRPKPLYEPHYVRAHERKLALDVLSVSIDSTPKQSKNSDMVMTDFRPTASLKQVSLWDLDANLMIRPVNISGFDFPADVDMYVRIEFSVYVGTLTLASKSTTKVNAQFAKWNKEMYTFDLYMKDMPPSAVLSIRVLYGKVKLKSEEFEVGWVNMSLTDWRDELRQGQFLFHLWAPEPTANRSRIGENGARIGTNAAVTIEISSYGGRVRMPSQGQYTYLVKHRSTWTETLNIMGDDYESCIRDPGYKKLQMLVKKHESGIVLEEDEQRHVWMWRRYIQKQEPDLLIVLSELAFVWTDRENFSELYVMLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLNEQLSPVTFHLFILPLIQALKYEPRAQSEVGMMLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEYRRISLLMEAYLRGNEEHIKIITRQVDMVDELTRISTLVKGMPKDVATMKLRDELRSISHKMENMDSPLDPVYKLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDMLVLQVLEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVIRSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVSLFTLMLGMELPELSTKADLDHLKKTLFCNGESKEEARKFFAGIYEEAFNGSWSTKTNWLFHAVKHY
What is the function of this protein?
Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause (PubMed:8700226, PubMed:21750263).  Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3 (PubMed:25383666).  Could function in the development or neuroendocrine signaling of the dauer pathway (PubMed:8700226).  Mediates susceptibility to enteropathogenic E. coli infection (PubMed:16091039).  May negatively regulate AYI interneuron neurite outgrowth (PubMed:22069193).  Plays a role in aversive olfactory learning when an odor is associated with food deprivation (PubMed:27383131).  Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning (PubMed:27383131).
What are the official names of this protein?
Phosphatidylinositol 3-kinase age-1, PI3-kinase age-1, PI3K age-1, PtdIns-3-kinase age-1, Aging alteration protein 1.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
Protein: RPOZ_NEIG2
Sequence: MARITTEDCTGKISNHFDLTLVAARRARQLENGNTPLVDDVRNNKPTVTALREIAAGHIGTELLTRNK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: TRXB_COXBU
Sequence: MNKPQHHSLIILGSGPAGYTAAIYAARANLKPIMITGMEQGGQLMTTTDVDNWPGEAPGLQGPQLMERMQKHAERLDTQFIFDHINEADLNQRPFLLKGDNATYSCDALIIATGASARYLGLPSEKAYMGKGVSACATCDGFFYRGKKVAVVGGGNTAVEEALYLSHIASHVTLIHRRDKLRAEKMLSAQLIKKVEEGKVAIVWSHVIEEVLGDDQGVTGVHLKHVKEEKTQDLTIDGLFIAIGHDPNTKIFKEQLEMDEAGYLRAKSGLQGNATATNIPGVFAAGDVTDHVYRQAITAAGMGCMAALDAERYLDSLNQA
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC6_ALAES
Sequence: IDINNGENIFTANCSACHAGGNNVIMPEKTLKKDALADNKMVSVNAITYQVTNGKNAMPAFGSRLAETDIEDVANFVLTQSDKGWD
What is the function of this protein?
Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.
What are the official names of this protein?
Cytochrome c6, Cytochrome c-553, Cytochrome c553, Soluble cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PetJ subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: RS15_TROW8
Sequence: MARKLDMDKGAIISEYGLSKGDTGSPEVQIALLTARIARLTQHLKEHSFDHHSRRGLMLMVGRRRRLLSYLHGVDVSRYRAILSNLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RLMN_NITEC
Sequence: MINLLDFNKTGLIHFCEEMGEKPYRARQLLRWVHRFGKTEFIEMSDLAKTFRQKLMERAVVHPPEIISDHTAGDGTRKWLLSTGTGNAVEMVFIPEPNRGTLCVSSQVGCALACSFCSTGRQGFNRNLSVAEIIGQLWWANRLLEGQVGELFSPDVAQIRADNTDTRRPVTNVVMMGMGEPLANFENVVTALDLMLSDDAYGLSRRRVTVSTSGLVPALDRLRERCPVALAVSLHAPNDALRDQLVPINKKYPIRDLLAACERYLPAAPRDFITFEYVMLRDVNDSIALARELVQVVRNIPCKLNLIPFNTFAGSGYERSNTDAIDNFRDVLMQAGIVTTVRKTRGDDIAAACGQLAGQVKDKTRRTGTCGSGRAVVTG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CISY_LEIMA
Sequence: MRAVRCSLIRGVAGLRMASSALDEMKEQMLRRWKEDQKKIDDLRKKHGHEKLCDATIDAVYGGMRGITGLVYEPSLLDPAEGIRFRGLTILECQEMLPKAPGGKEPLPEAMFWLLMTGEVPTEEQVRGLNAELHRRADPEAIAAAQKAIAALPRNAHPMTAFSVGVLALQSYSKFAAAYAAGKSNKKTYWEYALEDSLDMLARTPTVAAMIYNRETKGQVELAAPSNSDLDWAANFAKMMGYQDEEFWECMRLYLSVHADHEGGNVSAHTTTLVASALSDPYLAFSAGLNGLAGPLHGLANQEVLNYLLSMQERVKADGVNMHDEAALEKALSNYTWELLNSGQVVPGYGHAVLRKVDPRYTCQRNFCLRHKFDDDLFKLVNTIYSIMPGILKEHGKTKNPYPNVDAHSGVLLQHYGLTEQNYYTVLFGLSRQMGVLAGVVWDRLQGRPLERPKSITTEMLAKKYLCNSL
What are the official names of this protein?
Probable citrate synthase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: AB31G_ORYSJ
Sequence: MWAAEAAFARSGSWREEEDEQEALRWAALQRLPTVARARRGLLRSPAPGEDRVQGDDALCEVDVAGLSPGDRTALVDRLLADSGDVEDFFRRIRSRFDAVQIEFPKIEVRYEDLTVDAYVHVGSRALPTIPNFICNMTEAFLRHLRIYRGGRVKLPILDNVSGIIRPSRMTLLLGPPSSGKTTLLLALAGRLGPGLKVSGNITYNGHHLNEFVPQRTSAYVSQQDWHASEMTVRETLEFAGRCQGVGIKYDMLVELLRREKNEGIKPDEDLDVFMKALALEGKQTSLVAEYIMKVYGLDICADTIVGDEMIKGISGGQKKRLTTGELLVGSARVLFMDEISTGLDSATTYQIIKYLRHSTHALDGTTIISLLQPAPETYELFDDVILISEGQIVYQGPREYAVDFFAGMGFRCPERKNVADFLQEVLSKKDQQQYWCHYDYPYQYVSVSKFAEAFKTFVIGKRLHDELAVPYNRHRNHPAALSTSNYGVRRLELLKSNFQWQHLLMKRNSFIYVFKFIQLLLVALITMTVFFRSTMHRDSVDDGIIYLGALYFAIVMILFNGFTEVSLLVTKLPILYKHRDLHFYPPWAYTLPSWLLSIPTSLIESGMWVLVTYYVVGYDPQFTRCLGQFLLLFFLHQTSLALFRVMASLGRNMIVANTFGSFALLVVMILGGFIITKESIPAWWIWGYWISPMMYAQNAISVNEFLGHSWSQQFANQNITLGEAILTGYGLFKEKYWFWIGVGALFGYAIVLNFLFTLFLTLLNPIGNIQAVVSKDDIQHRAPRRKNGKLALELRSYLHSASLNGHNLKDQKGMVLPFQPLSMCFKNINYYVDVPAELKSQGIVEDRLQLLIDVTGAFRPGILTALVGVSGAGKTTLMDVLAGRKTGGLIEGSITISGYPKNQETFTRISGYCEQNDVHSPCLTVIESLLYSACLRLPSHVDVNTRRVFVEEVMELVELNALSGALVGLPGVNGLSTEQRKRLTIAVELVANPSIVFMDEPTSGLDARSAAIVMRTVRNIVNTGRTIVCTIHQPSIDIFESFDELLFMKRGGQLIYAGPLGSKSRNLVEFFEAIPGVPKIRDGYNPAAWMLEVTSTQMEQILGVDFAEYYRQSKLFQQTQEMVDILSRPRRESKELTFATKYSQPFFAQYAACLWKQNLSYWRNPQYTAVRFFYTVIISLMFGTICWKFGSRRETQHDIFNAMGAMYAAVLFIGITNATSVQPVISIERFVSYRERAAGMYSALPFAFSLVTVEFPYILVQSLIYGTIFYSLGSFEWTAVKFLWYLFFMYFTLLYFTFYGMMTTAITPNHTVAPIIAAPFYTLWNLFCGFMIPRKRIPAWWRWYYWANPVSWTLYGLLTSQFGDLDQPLLLADGITTTTAVDFLRDHFGFRHDFLGVVAGMVAGFCVLFAVVFALAIKYLNFQRR
What is the function of this protein?
May be a general defense protein.
What are the official names of this protein?
ABC transporter G family member 31, OsABCG31, Pleiotropic drug resistance protein 6, OsPDR6.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SERCL_ARATH
Sequence: MGHEWIDAEREFKWSEDVKVESEVTEIVLVRHGETTWNAAGRIQGQIESDLNEVGLKQAVAIAERLGKEERPVAVYSSDLKRAKDTALMIAKTCFCPEVIEVPDLKERHVGSLQGLYWKEGAEKEPEAYSAFFSSQNDLEIPGGGESFDQLADRSMDALEQIAKKHKGERVIVVTHGGVLRAIYLRITQASSAGKLLNASVNVVHLRDQKWIIDSWSDVSHLSSVGFLQRGFDGDAKP
What is the function of this protein?
Phosphoglycerate mutase-like protein lacking PGM activity, but having a low metal-independent phosphoserine phosphatase activity in vitro.  May be involved in serine biosynthesis.
What are the official names of this protein?
Metal-independent phosphoserine phosphatase, iPSP, Phosphoglycerate mutase-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family.
Protein: ISPG_ECODH
Sequence: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNNDMIDQLEARIRAKASQLDEARRIDVQQVEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: RL19_THISH
Sequence: MSKIIQQLEAEQMNREVPDFTPGDTVVVQVKVKEGNRERLQAFEGVVIAKRNRGLNSAFTVRKISHGEGVERVFQTYSPAVAEIQVKRRGSVRRAKLYYLRDLTGKAARIKEDIKRG
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RSMJ_PSEMY
Sequence: MTDEPRNASIRMDALQAHHAEAAARWATRLGLPRVGETDFALQLGDQGLQLVELGDKAPGPVRVDFVEGAAAHRRQFGGGSGQMIAKAVGVQSGIRPRILDATAGLGRDAFVLASLGCEMTLIERQPLIAALLEDGLQRAELDLEVAPIAARMRLLTGNAIDLMQNWQGEAPQVIYLDPMFPHRDKSALVKKEMRLFRPFVGDDLDAPALLAAALALASHRVVVKRPRKAPAIEGTKPGYVLEGKSSRYDVYPKKKLEGA
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_BURCH
Sequence: MKVISSIQELRDQLRGQNRTAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLQDDIEKLQQNNVYVLFAPTERDMYPEPQEYRVLPPDDLGGILEGEFRPGFFAGVCTVVTKLMSCVQPRVAVFGKKDYQQLMIVRRMCQQLALPVEIIAAETVRDEDGLALSSRNRYLTTDERKEAPELAKTLQRVRDSVLGGERDLGKLEQHAHTHLAERGWVPDYIAIRRRANLIAPSAAELEAGEPLVVLAAAKLGATRLIDNLEI
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STK4_COLGU
Sequence: METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATVLQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.  Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.  Phosphorylates MOBKL1A, MOBKL1B and RASSF2.  Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).  Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.  Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage.  Acts as an inhibitor of PKB/AKT1.  Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
What are the official names of this protein?
Serine/threonine-protein kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Protein: YCFP_SHIFL
Sequence: MIIYLHGFDSNSPGNHEKVLQLQFIDPDVRLISYSTRHPKHDMQHLLKEVDKMLQLNVDERPLICGVGLGGYWAERIGFLCDIRQVIFNPNLFPYENMEGKIDRPEEYADIATKCVTNFREKNRDRCLVILSRNDEALNSQRTSEELHHYYEIVWDEEQTHKFKNISPHLQRIKAFKTLG
What are the official names of this protein?
UPF0227 protein YcfP.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: GLO2_TOLAT
Sequence: MLQVQTIPSRQDNYIWLIKQGNQAIVVDPGESAPVIERLRQQSLNLKAIFVTHHHHDHVDGVAELLALYPQCAVYGPQITLTDVPQLQTMRDQDLISFPDLDLTFTVWHTPGHTAEHIVFHGHGALFCGDTLFSGGCGRLFSGTAEQMYHSLQRLASLPEDTLVYPAHEYTYNNLSYCLQAEPDNVFTIKRIKEVSKLRQQGCPTLPSTIGIEKQSNVFLRTHMPSVAVFAQNSSELYLENEIQIFAILREKKNNL
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: MURQ_PROM1
Sequence: MSDTNNHSKNIIHRILTEQINLTSNELDTKSTKEIVNIFSEADKEPQKAVERVIPELINAIDEITARLKSKGRLFYIGAGTSGRLGVLDASECPPTFCSNPDLVQGIIAGGIPSLTRSSEHLEDVSEIAIADLKDRNFSYRDVLIGITASGRTPYVIAALNYSKSISALSISISSVPESDSTLDNDIDIRLITGPEILAGSTRLKAGTATKMALNIISTSVMIKLGKVYGNRMIDLSVSNDKLLDRAIGILFDIGSVDKDTAVRLLKKTNGSVKLSLLIALSGMDVIDAKQLLNDSKGNLRTALISFKDN
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: MDCC_PSEPG
Sequence: METLTFNFPAAEPGRGRTLVGCVSSGDLEVLIEPGTAGSLQIQVVTSVNGSAARWAQLFQRLFEGRAWPAVNIDIHDFGATPGVVRLRLEQGFEEIAHD
What is the function of this protein?
Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.
What are the official names of this protein?
Malonate decarboxylase acyl carrier protein, Malonate decarboxylase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the MdcC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_SYNJB
Sequence: MALSLGLGLALSALVIGIRPQVVVPFGLSALGSALLGSLLIPGLRRWKAGQVIRQEGPQSHQKKAGTPTMGGISFLPVGLLVAGIWSGWDPHWLAVALLTLAYSFVGWLDDWLVIRQQSNKGLSPQHKLLLQVGVALGFCVYLAWQGIPTSLTLPGIGTLSLGWLFWPLALFVLVGTNNAVNLTDGMDGLAAGVVAILLIGLGLLHRDPELSVLAFTLSGACLGFLVHNHHRARLFMGDTGSLGLGGALAGLALLGDQLWALALMGGVLVAEALSVMLQVGYFQYTKRKTGTGQRLLRMSPLHHHLELGGWSEVQVVGSFYGVTALLVGLGWAWWHWTGM
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYP_LEUCK
Sequence: MKQSKLLMPTLREVPADAEVKSHQLLLKAGFIRPVSAGTFSYLPMAKRVLNKIEQIIREEMDRIDANEMLVPEILPAELWQKSGRYTTYGPNLYKFKNRQDRDFILGPTHEETFTQLMADDIKSYKKLPLVVYQIQPKFRDENRPRFGLLRTREFIMKDAYSFSADQAGLDTAFRNMESAYTNVFDRIGLNYRAIVGDAGAMGGSDSKEFSAPAAAGEDIIAYSDTTDYAANLEMAKDFYERQKPTFSAEPLEKIDTPNEKTIEELSQLLDVPAEKLAKTIMFMADGELVAVVTTGDFEVNDVKVQNFLQADTLELAEEGQVKALIGASFGSLGPVKLPENVRLLVDERAADLVNFAAGANEDGKHYLNINWQRDVQLTEENIGDFRTAREGDVAVDGHGHLVFTKGIEIGHIFKLGTRYSKAMGAQVLDENGRQVDMIMGSYGIGVSRLLSAIVEQKADDDGLVWPASVAPFDVHIVPVNTKDDEQAGVASQLEELLTKQGLEVLIDDRKERAGVKFADADLIGLPIRITVGKKASEDVVEVKVRASNTNIEMRVSEVVDSVSVLLNGDK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.