PharMolix/UniProtQA huggingface dataset:
Protein: NUOH_ECOL5
Sequence: MSWISPELIEILLTVLKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLAFAIVPVSPGWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMTDIVNSQAHVWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTISALMVTLFFGGWQGPLLPPFIWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKICLPLTLINLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GCSPA_NITEU
Sequence: MPFIPHTEEDVAEMLTSIGARSIDELFDEIPAELKTGKLTQVPPGLSEMEISRLMYERAQQDGFYLSFIGAGAYEHHIPAAVWQITTRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASLAGMDVSNASLYDGASALAEAALMAVRQHRTSRRILVPQTVHPVYRSVMRTIVRNQAIEVVEVPYDPATGQVAIDKLDQFAQEEFAALIIPQPNFFGVLEQVDALTDWAHDKQSLAVAVVNPTSLAMLKPPGEWGRRGADIAVGEGQPLGIPLSSGGPYFGFMTCKQELVRQMPGRIIGRTTDLEGKEGFALTLQAREQHIRRSKATSNICTNQGLMVTAATIYMSLLGPEGLYRVAAHSHANTVALVEQLEKLPGVKKAFHSPFFHEAALQLSVPADKVLNRLKAQGVLGGVLLENHYPDLKNTLLVCATETKTAEDLDKYTEVLRQALAASA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: MTAL1_PICAN
Sequence: MMFHVLCFFGNRTSRVANLCLQLKFPPHNDSPKMALDELNLSFLTHLPQIPTTSPLLKRLLTEYGAIDNGKDSLNKVAPKKSSRHRVQKEKKRLNGFMAFRSFYSRNIANYNSQKALSQDLADAWNREKHQQIWSLYAIQYNHSKSKEPFSRWLEMKLSNKLGKFNSDDPTTRREINVMSHIVVEDVFQECSSQY
What is the function of this protein?
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion.
What are the official names of this protein?
Mating-type protein ALPHA1, MATalpha1 transcription factor.
What is the protein family that this protein belongs to?
Belongs to the MATALPHA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS14Z_THEAQ
Sequence: MARKALIEKAKRTPKFKVRAYTRCVRCGRARSVYRYFGLCRICLRELAHKGQLPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: TRPA_HALSA
Sequence: MTRSDLAAAFDDGPALVSYVVAGDPTPAATAEYIDALVDGGTDVIELGLPFSEPVAEGTTIQNAIKRALDAGMTPDAYLDLVARIDADVPVVCMTYYNLLFQYGDRAGPAAFVSAAAEAGVSGFVVPDLPVDESGPLREACRAHGLDLVFVVAPTTTADRRERMLDLTTGFVYVQGRVGTTGAREEVSAATPDALAALQHTDIPKAVGFGVSSGEQAREITASGADGVIVGSAYVDTVADGVADDDPPSVVADRLRDLAAELKAGAARGVPEPEHK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: DAPE_BRADU
Sequence: MTDALSIARDLIRCPSVTPADAGALGVLENALNAAGFTCHRVTFSEPGTADVDNLYARIGSEGPHITFAGHTDVVPAGDESAWSVGAFSGEVKDGFLHGRGAVDMKGGIACSVAAVLEHLAANGGKPRGDGTGSISFLITGDEEDVSINGTIKLLKWAAERGETFDHCVLGEPSNVETLGDTIKVGRRGSQSGTLYVDGVQGHVAYPHRASNPVPDISRLIVAISDEPLDHGSAQFQASNLEFTSVDVGNKANNVIPGEARAKFNIRYNDNHTQASLRELVETRLAKACGNRIKARIVWEPSNSNVFVTKPGPFTDLAVSAIEEITGRKPELSTSGGTSDARFISSYCPVIEFGLVGQTMHQVDERVPVKDLEKLTQVYRGILTRYFG
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: IDRP2_DENS1
Sequence: MTTHQSIRRLSRIAALVGLAFVAGTVAAADGKAELQALPEAKAGNADMVELGKHLFFDTRLSGDMGVSCASCHDPAKGFSDGMPLSAGYPSVEYFRNAPTLINSRFKNVFMWDGRLDGADMGTLVRDMLTEAHTMNMDSRLMQERLSQVPEYVAMWQKFRKDDINGMRVYGVVGEYVKTLVSQNAPIDRFLKGDGSALTSQQKDGYEIFTGKGGCVACHNGPLGSDGQVHNTGVPENPEVLKNPNRTVTLLRHYATSGMPNYMNARTDLGHYAISKDPADMNKFATPSLRELKYTAPYMHNGMLTTLDQVVDFYNQGGGQGSELTPLGLSGSEKKALVAFLEALSGEPLNVVAPTLPDYQPRQFGKN
What is the function of this protein?
Involved in iodate respiration (PubMed:34215855).  May play a critical role in detoxification of inadvertent H(2)O(2) generated by the iodate reductase IdrA/IdrB (PubMed:34215855).
What are the official names of this protein?
Cytochrome-c peroxidase IdrP2, Iodate reductase subunit IdrP2.
What are the subcellular locations of this protein?
Periplasm.
Protein: PSBB_OENAR
Sequence: MGLPWYRVHTVVLNDPGRLLAVHIMHTALVAGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWSITGGTVTNPGIWSYEGVAGSHILFSGLCFLAAIWHWVYWDLAIFSDERTGKPSLDLPKIFGIHLFLSGLACFGFGAFHVTGLYGPGIWVSDPYGLTGEVQPVNPAWGVEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVGAGLAKNQSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDSGDGIAVGWLGHPIFRDKEGRELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDTQVEFGAFQKLGDPTTRRQAV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: KATG_ACIAC
Sequence: MTQDATKCPFHAAAASGGIINKDWWPNQLRLDLLNQHSSKSDPLGAGFDYAEEFKKLDYEGLKRDLRALMTDSQDWWPADFGHYGPQFVRMTWHAAGTYRTGDGRGGAGRGQQRFAPLNSWPDNVNIDKSRRLLWPIKQKYGQKISWADLLVLTGNVALETMGFRTFGFAGGREDTWEPDQDVYWGSEKTWLGGDARYGKGTPGDGTLVAEPAMHGHEKDRVLENPLAAVQMGLIYVNPEGPEGNPDPVAAAHDIRETFARMAMNDEETVALIAGGHTFGKTHGAGTADHVGPEPEAAGLEQQGLGWASSFGSGKAGDAITSGLEVTWTSTPAQWGNEFFENLFKFEWELTKSPAGAHQWQAKNAPATIPDAHDPSKKRVPTMLTTDLSLRFDPAYEKISRRFLENPQAFAEAFARAWFKLTHRDMGPRARYLGPEVPKEELVWQDPIPAVTHDLVDAADVAALKARVLASGLTVQELVGTAWASASTFRGSDKRGGANGARIRLAPQKDWAVNQPEQLARVLQVLEGIQREFNKGADGDKRISLADLIVLAGAAGVEQAARAAGVAVTVPFHPGRADARQDQTDVESFSVLEPSADGFRNYTKARYSVPAEVLLLDKAQLLTLTAPEMTVLVGGLRAININVGGATHGVFTATPGALTNDFFANLLDMSTEWKPAGDLFEGRDRKTGEKRWTGTRVDLVFGSNSVLRSLAEVYASADAKEKFVRDFVAAWAKVMDLDRFDLR
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: RL2_BIFLD
Sequence: MAIRVYKPTTAGRRNASVSDFSELTRSTPEKSLVRKKSKTGGRNSYGRITSRHRGGGHKRQYRLIDFKRWDKDGVPAKVAEIEYDPNRSARIALLHFADGEKRYIIAPKGIKQGDVIETGAQADIKPGNNLPLKNIPTGTVVHAIELRPLGGAKIARSAGAAVQLVAKDGAYAQLRMPSGEIRNVDARCRATVGEVGNEDHANIQLGKAGRARWIGRRPITRGESMNPVDHPHGGRTRGGKPPVSPWGKGEVRTRRPKKASNKMIVRRRPSGKNRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CTU1_DICDI
Sequence: MENTATKKKSKLCEVCNVSRPVLKRPKTGEMICKECFYTVFEDEIHHTIISNNLFKRGDRVAIGASGGKDSTVLAEIMTLLNKKYDYGLDLFLLSIDEGITGYRDDSLETVKRNQEQYQIPLKILSYKELYNWTMDDIVKEIGLKGNCTFCGVFRRQALDRGAVMLKANKIVTGHNADDIAETVLMNLLRGDIPRLQRCVNIITGSEGALPRSKPFKYTYQKEIVMYAYFKKLDYFSTECIYAPNAYRGHARDFLKDLEAVRPSIIIDIIHSAENFHFREENKMPVQRNCIQCGYICSNDICMACDLLKNLNSGLAKVKLSINLKRGKDNNNNSNNNDNNNTLKLESTSAATTTTTTVSN
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, ATP-binding domain-containing protein 3, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEX1_YEAST
Sequence: MNFSSIFKSISNFQFPYTIEETAITETALWQCFDGTRKADSLPVTVFKAKRSPENESLILNAVHKSKILKIPGLCTVLETFDSDPQSTFIVTERVVPFPWDNLGSLSQNKFGVELGISQLLATLGFLKNFVLGTLSKDSVFINIKGEWVLFGLELCSSKEGLSAFEFASRARSYYNIIGSQLPCEDPNTIDSMGLGLLIKSLMAPSCLPKDWIVNVNMISDGKITIENFRKRLENTETWRSNPLINFYQELRELHIKDPQGKLVVMSNLENLYLESREIFRNLTPGMIENFIIPELCEIIKLLMTQSISSAASPIGMNFNASHKLVPFLAIVLDLTSETNTFPVGFNDLITQSFKLPDRQVRFLLLIYLPKLIGPLSKSEISSRIYPHFIQGLTDSDATLRLQTLKTIPCIVSCLTERQLNNELLRFLAKTQVDSDVEIRTWTVIIISKISTILSTSVGNRSNILATAFTKSLKDPQVKPRLAALYGLEKSIELFDVNTIANKILTVIAPGLLDKSPIVRGRAKILFEEYLEKLEKEAQLIQTNDSTADSEDVKDIDFENYGCDEEDMNKEDNLLAAQFLNNLRLNSPSATTPSNITESEIDSAQDGSGWDDLSDTDGFITNGTTESFDETTNPVTTASTPKLFGKPIKINKSWNDELNDDGWIQDESGPSKVPQKHTRPQNSTLAKSIAPSSRLSIKKKKTTILAPRNIASNSTVTTKSSLSNKTARSKPISSIRGSVTKKGNVDGWDDDGDSDSWDTNW
What is the function of this protein?
Component of the nuclear tRNA export machinery that my collect tRNA from the nuclear tRNA export receptors of the aminoacylation-dependent export and may deliver aminoacylated tRNAs to the translation machinery pathway at the nuclear pore complex.
What are the official names of this protein?
Cytoplasmic export protein 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCED_ECOL6
Sequence: MQKVKLPLTLDPVRTAQKRLDYQGIYTPDQVERVAESVVSVDSDVECSMSFAIDNQRLAVLNGDAKVTVTLECQRCGKPFTHQVYTTYCFSPVRSDEQAEALPEAYEPIEVNEFGEIDLLAMVEDEIILALPVVPVHDSEHCEVSEADMVFGELPEEAQKPNPFAVLASLKRK
What is the function of this protein?
Plays a role in synthesis, processing and/or stability of 23S rRNA.
What are the official names of this protein?
Large ribosomal RNA subunit accumulation protein YceD, 23S rRNA accumulation protein YceD.
What is the protein family that this protein belongs to?
Belongs to the DUF177 domain family.
Protein: WNT7B_ANSCE
Sequence: SGSCTTKTCWTTLPKFREIGYILKEKYNAAVQVEVVRASRLRQPTFLKIKQIKSYQKPMETDLVYIEKSPNYCEEDASTGSVGTQGRLCNRTSPNADGCDMMCCGRGYNTHQYTKVWQCNCKF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).  Required for normal fusion of the chorion and the allantois during placenta development (By similarity).  Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).
What are the official names of this protein?
Protein Wnt-7b.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: RL20_MYCTU
Sequence: MARVKRAVNAHKKRRSILKASRGYRGQRSRLYRKAKEQQLHSLNYAYRDRRARKGEFRKLWIARINAAARLNDITYNRLIQGLKAAGVEVDRKNLADIAISDPAAFTALVDVARAALPEDVNAPSGEAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ARGR_STRMU
Sequence: MNKLSRQNKIKQIIRSKHIGTQEELKHQLELEKVFVTQATLSRDMRELGLFKSRDKEGYLYYEIPENGSTIFTPAALYYIKKVFRTDALLVFHTNLGEADVLANLIDSESHSEILGTVAGADTLLVICKNEEIASQLESDVLSNL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCD_COXBN
Sequence: MNWFTKLLPKISTAKKKGVPEGVWHKCPSCTAVLYRVELERNLEVCPKCYYHIRLDPRKRLAQFLDEGEQEELAEDILPVDRLKFRDSKKYKDRLSAAQKATEEKEALVVYKGNIYGNPIVAAAFNFFFVGGSMGAAVGERFAAGVEAAISERLPFVCFSTSGGARMQEGLFSLFQMAKTSAVLARLAEYKLPYISVLTDPTMGGVSASLAMLGDVIIAEPNALIGFSGPRVIEQTIRQTLPEGFQRSEFLLEHGAIDMVVDRRELKSTIASLITKLTHQPPPDLPVEESV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSU1_SCHPO
Sequence: MASKIASLFSPSETASKDQHENVAEDLELGTASSQSDGIHETNSEYDEKKREESPEVIDISNLISSDHPAHPQNWHWAKRWSIVFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVDINAKYGWRWLYYINIIVGGFFLIVILIIPETLPIKVITRYENAKGRIVEGIPKNNLKEVLKKCKFVTTMGFRMMLTEPIILSMGLYNFYAYGISYFFLTAIWPVFYDTYKMSEMGASCTYLSGFVASTLLFLYQPIQDWIFRRDKAKNNGVARPEARFTSALFITLLFPAGMFLFAFTCHPPFPWMSPIVGNSMVTVANGHNWMCILNYLTDSYPLLSGSAVAAFTLPSFIGATVFAHVSQIMFNNMSVKWAVATMAFISISIPFIIYTFYFFGQRIRALSSLTGNKALKYLPLENN
What is the function of this protein?
Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine.  Also imports, but does not export, amiloride and so confers sensitivity.
What are the official names of this protein?
Vitamin B6 transporter bsu1, Amiloride transporter car1, Changed amiloride resistance protein 1, Vitamin B6 uptake protein 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. CAR1 family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Note=During mitosis, localizes also to the septum.
Protein: ILVC_ANASK
Sequence: MATIYYDKDANLDLLKKRKVAIIGYGSQGHAHALNLRDSGVDVRVGLAAGSKSKAKAEGAGLRVLSVAEASKEADVIMVLIPDQTQKKVYDEEIAPHLSKGKALLFAHGFNIHFVQVRPPADVDVLLVAPKGPGHMVRRQYQDGRGIPGLVAVHQDATGQAKAVGLAYARGIGCTRAGVLETTFKEETETDLFGEQAVLCGGAAALVKNGFEVLVEAGYQPESAYFECLHELKLIVDLMYEGGLAWMRHSISDTAEYGDYTRGPRVVDGRSKDEMRKILKEIQGGHFAKEFILENQAGGPTMARYRAAEAAHPIEEVGKRLRDMMSWIREAKKDSSDPGSR
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: TRMB_BURP1
Sequence: MIHDDDPNAPGAPHDDDATAAPASATRAAPAAGDDDDANPLHLRRIRSFVTRAGRVSTGQRRAIDELGPRFVIPYGSAQPDWDAIFGRRAPRVLEIGFGMGASTAEIAALRPGDDFIGVEVHEPGVGALLKLIGEQQLSNIRIIQHDAVEVLAQMIAPDSLDGVHIFFPDPWHKARHHKRRLIQPPFVAQLAAHLKPGAYLHCATDWQNYAEQMLEVLSADPSLENTAQDYAPRPGYRPVTKFERRGLRLGHGVWDLVFRKKHAG
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RS1_MYCLE
Sequence: MSIPAVPSPQIAVNDVGSSEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLILSKKRAQYERAWGTIEALKEKDEAVKGIVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNQLQKGAIRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVQVGNEVTVEVLDVDMDRERVSLSLKATQEDPWRHFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAVGDDAMVKVIDIDLERRRISLSLKQANEDYIEEFDPAKYGMADSYDEQGNYIFPEGFDPDSNEWLEGFDTQRAEWEARYAEAERRYKMHTIQMEKFAATEEAGHGSSEQPPASSTPSAKATGGSLASDAQLAALREKLAGSA
What is the function of this protein?
Binds mRNA; thus facilitating recognition of the initiation point.  It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
What are the official names of this protein?
30S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS1 family.
Protein: MTA70_DROME
Sequence: MADAWDIKSLKTKRNTLREKLEKRKKERIEILSDIQEDLTNPKKELVEADLEVQKEVLQALSSCSLALPIVSTQVVEKIAGSSLEMVNFILGKLANQGAIVIRNVTIGTEAGCEIISVQPKELKEILEDTNDTCQQKEEEAKRKLEVDDVDQPQEKTIKLESTVARKESTSLDAPDDIMMLLSMPSTREKQSKQVGEEILELLTKPTAKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPDVDAGENVTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDESLGDCSFLNTCFHMATCKYVHYEVDTLPHINTNKPTDVKTKLSLKRSVDSSCTLYPPQWIQCDLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVTGRAMELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGLDCDVIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQKRYPDGNCMSPASANAASINGIQK
What is the function of this protein?
Catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:27919081, PubMed:28675155).  In the heterodimer formed with Mettl14, constitutes the catalytic core (By similarity).  Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:27919077, PubMed:27919081, PubMed:28675155).  M6A methylation is also required for neuronal functions (PubMed:27919077).  During oogenesis, required for egg chamber development probably as part of the N/Notch signaling (PubMed:21873203).
What are the official names of this protein?
N6-adenosine-methyltransferase MT-A70-like protein, Inducer of meiosis 4, Methyltransferase-like 3.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YBJQ_ECOLI
Sequence: MQFSTTPTLEGQTIVEYCGVVTGEAILGANIFRDFFAGIRDIVGGRSGAYEKELRKAREIAFEELGSQARALGADAVVGIDIDYETVGQNGSMLMVSVSGTAVKTRR
What are the official names of this protein?
UPF0145 protein YbjQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: RF1_RUEPO
Sequence: MIPEERLDQITQRFQYLEAAMADGASGSDIAALAKEYSDLRPVVEQIAAWRQLCADMDEARAMLSDPDMKALAEEELPLLKARLPEAEQALQLALLPKDAADARPAMLEIRPGTGGDEAALFAGDLLRMYQRYAEARGWKLELIELQETELGGIKEVVARISGENVFARLKYESGVHRVQRVPETESGGRIHTSAATVAVLPEAQDVDIQIDPGDIRIDTMRSSGAGGQHVNTTDSAVRITHLPSGIVVTSSEKSQHRNREIAMQVLKTRLYDLERQRLDRERSASRSAQVGTGDRSERIRTYNFPQGRMTDHRINLTLYKLDAVMQGDLDEVIDALAADGQARMLAEMGQ
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AVR2A_SHEEP
Sequence: MGAAAKLAFAVFLISCSSGAILGRSETQECIFYNANWERDRTNRTGVESCYGDKDKRRHCFATWKNISSSIDIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNERFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLVAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGGFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFVEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKLAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTVVTNVDFPPKESSL
What is the function of this protein?
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.  Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.  Receptor for activin A, activin B and inhibin A.  Mediates induction of adipogenesis by GDF6.
What are the official names of this protein?
Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: THIM_PASMU
Sequence: MLNPTYLQQIRSQNPLIHNITNVVAANFSANGLLAIGASPLMSAAMEEMHEVPRLSQALVINIGTLMGKEVDAMVLAGKTANEVGIPVVLDPVGVGATTFRKQTVARLLKEVKFAAIRGNAGELATIAEVNWQAKGVDAGSGEADLAQIAHIVAKTYQCIAMISGATDYLSDGEHHAQIHNGTPLFPKITASGCLLSAVCGAFLAVAKPEQYFDAMLEACTAYAIAGELAAQGLKTTQHGQFYVGLLDQLAHLSPETINQYARISYE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.