PharMolix/UniProtQA huggingface dataset:
Protein: T22D3_HUMAN
Sequence: MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV
What is the function of this protein?
Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
What are the official names of this protein?
TSC22 domain family protein 3, DSIP-immunoreactive peptide, Protein DIP, hDIP, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, GILZ, TSC-22-like protein, TSC-22-related protein, TSC-22R.
What is the protein family that this protein belongs to?
Belongs to the TSC-22/Dip/Bun family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Nucleus. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity).
Protein: TIF5B_ARATH
Sequence: MIIIIKNCDKPLLNFKEMEMQTKCDLELRLLTSSYDSDFHSSLDESSSSEISQPKQESQILTIFYNGHMCVSSDLTHLEANAILSLASRDVEEKSLSLRSSDGSDPPTIPNNSTRFHYQKASMKRSLHSFLQKRSLRIQATSPYHRYR
What is the function of this protein?
Repressor of jasmonate responses.
What are the official names of this protein?
Protein TIFY 5B, Jasmonate ZIM domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the TIFY/JAZ family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIAB_CHLL3
Sequence: MPEGRRFYIQTFGCQMNEADSGIIARVLLDAGFRRADTEQDADVVLLNTCAVRENAVEKIAHLLEHLKGAKKRRKTLQVGVLGCVPQHQREEMFSRFPAIDFIAGPDSYRRLPSLIDDAASAVRSAMLDFDPSETYVGIRQVREGRISAFIPVMRGCNNMCAFCVVPFTRGRERSQPLAMVTGEARELAEAGYREITLLGQNVNSYSDPASGATFSALLDAVALAAPDVRIRFTTSHPKDISVGLIDTIARRPNICRHVHLPVQSGSDSVLRRMNRGHGISEYLEKIRIIRDALPGVTLSTDIIAGFCGEREEDHRATLDLLRTVRFDAAFMFHYSTREGTLAARTLPDDVAETDKKRRLQEIIDLQQEISAENNRRQVGTVAEVLAESESRRSPGRLLGRTDGNRAVVFDRGECMPGDLVRVRLTSSTSATLSGSREGLIRAFLS
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXRN_BPT3
Sequence: MALLDLKQFYELREGCDDKGILVMDGDWLVFQAMSAAEFDASWEEEIWHRCCDHAKARQILEDSIKSYETRKKAWVGAPIVLAFTDSVNWRKELVDPNYKANRKATKKPVGYFEFLEALFEREEFYCIREPMLEGDDVMGVIASNPSAFGARKAVIISCDKDFKTIPNCDFLWCTTGNILTQTKETADWWHLFQTIKGDMTDGYSGIPGWGDTAEGFLNDPFIVEPVESVLKSGKNKGQTVTKWVKRAPDATETLWDCIKSIGAKAGMTEQEIIKQGQMARILRFEEYNYIDKEIYLWTPRS
What is the function of this protein?
This enzyme is essential for phage DNA replication; it is believed to function in the removal of DNA-linked RNA primers.  It is also necessary for host DNA degradation and phage genetic recombination.
What are the official names of this protein?
Exodeoxyribonuclease, Exonuclease.
Protein: ATPA_PEDPA
Sequence: MSIKAEEISALIKQQLENYQAELNVEETGTVTYVGDGIARAHGLNNALSGELLEFSNGVFGMVQNLESNDVGIVIMGNYDGIHEGDVVKRTGRIMEVPVGDALIGRVVNPLGEPLDGKGAIQTTKTRPVENKAPGVMQRKSVEQPLQTGIKAIDALVPIGRGQRELIIGDRKTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRRYGAMDYTIVVSAGPSEPAPMLYLAPYAGAAMGEEFMYNGKHVLIVYDDLSKQADAYRELSLILRRPPGREAYPGDIFYTHSRLLERAAKLSDDLGGGSMTALPFVETKAGDVSAYIPTNVISITDGQVFLDGDYFNSGTRPAIDAGTSVSRVGGDAQIKAMKKVAGTLRLDLASYRELESFAQFGSDLDKATQAKLARGRRTVEVLKQPLHQPLSVENQVMILYALTHGFLDNVPVDDIQRFQDELFDYIASNNKELTDEIRETKQLPDTDKMDAAIKSFAEHFQPTKEAK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UBAA_STRUB
Sequence: MNTIEKFENIKLFSLKKIIGGKTVNYGNGLYCNQKKCWVNWSETATTIVNNSIMNGLTGGNAGWHSGGRA
What is the function of this protein?
Heat-stable antibiotic with bacteriolytic activity against Listeria spp. , E. hirae, E. faecalis ATCC 19433, S. bovis 83, S. uberis 42 and L. lactis.
What are the official names of this protein?
Bacteriocin ubericin-A.
What is the protein family that this protein belongs to?
Belongs to the bacteriocin class IIA/YGNGV family.
What are the subcellular locations of this protein?
Secreted.
Protein: IRF1_BOVIN
Sequence: MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKSQRKERKSKSSRDARSKAKKKPYGEYSPDTFSDGLSSSTLPDDHSNYTVRSYMGQDLDIERTLTPALSPCGVSSTLPNWSIPVEIVPDSTSDLYNFQVSPMPSTSEAATDEDEEGKLTEDIMKLLEQTGWQQTSVDGKGYLLNEPGAQPTSVYGEFSCKEEPEVDSPGGYIGLISSDMKNMDPSLLDSLLTPVRLPSIQAIPCAP
What is the function of this protein?
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (By similarity).  Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (By similarity).  Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity).  Binds to a consensus sequence in gene promoters (By similarity).  Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (By similarity).  Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (By similarity).  Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53.  Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (By similarity).  Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (By similarity).  Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (By similarity).
What are the official names of this protein?
Interferon regulatory factor 1, IRF-1.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1.
Protein: SRY_GRAGR
Sequence: MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVSLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: ATPF1_PROA2
Sequence: MLIDWFTVIAELVNFLILVWLLKRFLYEPVLKAIDEREKKIASELQHAADVEKEAESRLIELQRKNEAFDNAHAQMIKDAEQEAVEEKRTLLNEAHREYDALRMRLQETLKHEETSLESRVTGRISAEVFSIARKVLQDLSGSSLEAQIADVFCQRLRESDPEDVAAMKDAVSRKSLNPLVRSTFPLSSSLQERIQAVVRDVFSIDTQLRFEEGDDMVGGIELSMNGHSVSWSVRSYLDSLEKMTAELLEGAE
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b 1, ATP synthase F(0) sector subunit b 1, ATPase subunit I 1, F-type ATPase subunit b 1, F-ATPase subunit b 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TTHY_MONDO
Sequence: MAFHSLLLLGLASLLFVSDAAPVIHGAEDSKCPLMVKVLDAVRGSPAVNVNVKVFKKSEEQTWEPFATGKTNDYGEIHELTNDEKFGEGLYKVEFDTFSYWNALGVSPFHEYADVVFKANDAGHRHYTIAALLSPYSYSTTAVVSNPKD
What is the function of this protein?
Thyroid hormone-binding protein.  Probably transports thyroxine from the bloodstream to the brain.
What are the official names of this protein?
Transthyretin, Prealbumin.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HNRPK_HUMAN
Sequence: METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVELRILLQSKNAGAVIGKGGKNIKALRTDYNASVSVPDSSGPERILSISADIETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCELRLLIHQSLAGGIIGVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPDRVVECIKIILDLISESPIKGRAQPYDPNFYDETYDYGGFTMMFDDRRGRPVGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRGGSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVGFSADETWDSAIDTWSPSEWQMAYEPQGGSGYDYSYAGGRGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVKQYSGKFF
What is the function of this protein?
One of the major pre-mRNA-binding proteins.  Binds tenaciously to poly(C) sequences.  Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences.  Can also bind poly(C) single-stranded DNA.  Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression.  When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity).  As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53.  This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.  As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein K, hnRNP K, Transformation up-regulated nuclear protein, TUNP.
Protein: MIS_MOUSE
Sequence: MQGPHLSPLVLLLATMGAVLQPEAVENLATNTRGLIFLEDELWPPSSPPEPLCLVTVRGEGNTSRASLRVVGGLNSYEYAFLEAVQESRWGPQDLATFGVCSTDSQATLPALQRLGAWLGETGEQQLLVLHLAEVIWEPELLLKFQEPPPGGASRWEQALLVLYPGPGPQVTVTGTGLRGTQNLCPTRDTRYLVLTVDFPAGAWSGSGLILTLQPSREGATLSIDQLQAFLFGSDSRCFTRMTPTLVVLPPAEPSPQPAHGQLDTMPFPQPGLSLEPEALPHSADPFLETLTRLVRALRGPLTQASNTQLALDPGALASFPQGLVNLSDPAALGRLLDWEEPLLLLLSPAAATEREPMPLHGPASAPWAAGLQRRVAVELQAAASELRDLPGLPPTAPPLLARLLALCPNDSRSSGDPLRALLLLKALQGLRAEWHGREGRGRTGRSAGTGTDGPCALRELSVDLRAERSVLIPETYQANNCQGACAWPQSDRNPRYGNHVVLLLKMQARGAALGRLPCCVPTAYAGKLLISLSEERISAHHVPNMVATECGCV
What is the function of this protein?
Plays an important role in several reproductive functions, including Muellerian duct regression during male fetal sexua,l differentiation and in the adult plays a role in Leydig cell differentiation and function (PubMed:1782869, PubMed:9435237).  In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:11861535, PubMed:11606457).  Binds to its sole type II receptor, AMHR2 that recruits type I receptors ACVR1 and BMPR1A which subsequently activates the Smad pathway (By similarity).
What are the official names of this protein?
Muellerian-inhibiting factor, Anti-Muellerian hormone, AMH, Muellerian-inhibiting substance, MIS.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: FLA4_SPIAU
Sequence: MIINHNMSAINANRVLGBTNADITKDL
What is the function of this protein?
Component of the core of the flagella.
What are the official names of this protein?
Flagellar filament 31.5 kDa core protein, 31.5 kDa major core flagellin.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Periplasmic flagellum. Periplasm.
Protein: CINA_BACCZ
Sequence: MNAEIIAVGTELLLGQIANTNAQFLSEKLASIGINVYYHTVVGDNNKRLQQAIEVAEERADMLIFTGGLGPTKDDLTKETIASSLAEELVYDEKALASIGDYFKRTGREFTENNKKQALVLDGATVFANDHGMAPGMGLNKNGKVYILLPGPPKEMKPMYVSYVEPFLRNFTTGENIYSRVLRFFGIGESQLEVKVQDLIDGQTNPTIAPLANDGEVTLRLTAKHQNVDEAEKLIQHVEDLILERVGEFFYGYDQEFLHYKAIELLKKKGLTLACAESLTGGLFGNQVTESAGVSSVFKGGVICYHNDVKQHVLHVPEEVLSTDGAVSKECARYLAENVKELLKADIGISFTGVAGPDASEHKEPGTVFVGLAIKDEPTVVFPLNLSGSRQQIRERSAKYGFYHLYKKLEEI
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: MCU11_RANGE
Sequence: GLFGVLAKVAAHVVPAIAEHF
What is the function of this protein?
Maculatin-1. 1 shows significant antibacterial activity against Gram-positive bacteria, less against Gram-negative bacteria.  Maculatin-1. 1. 1 is inactive.
What are the official names of this protein?
Maculatin-1.1.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPB_STRDO
Sequence: MKESVIEKTAMVFGQMNEPPGARMRVALTGLTLAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits (By similarity).
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RUVA_NOVAD
Sequence: MIAKLTGILDDTGPDWAVIDVNGVGYLVHCSAKTLTHLGLRGDKVVVHTEMQVSETDQRLIGFTSAGERAWFRLLTAVQGVGSKVALAILSALSVEELQRACAHGDSAMVARANGVGPKLASRIVNELKDKAGGLAGYASPVGPGGEAFVAPPGNASADAVSALQNLGFKPAVASSAVAAAVKELGEDAGLNDLVRVALKRAAG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RSMA_XANC5
Sequence: MNSSFSAPAKKSLGQHFLADRYYIDRIVQAVDPRAGQHLVEIGPGQGAITFPLLRRHGALTVIEFDRDLIAPLTEVAAPIGALSIIHRDVLSVDFTALANGTPIRLVGNLPYNISSPILFHALDHAAAVADMHFMLQKEVVDRMAAGPGSKVYGRLSVMLQAYCEVTALFVVPPGAFRPPPKVDSAVVRLVPRDPATVQINDRRRFADVVRAGFGQRRKTLRNALSTICEPAHFDAAQVRPDARAEQLEVADFIRLANVELA
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPEL_LISMC
Sequence: MLNEFIAIRRELHQIPETGYKELKTQAYLLDYISKLPSEHLEVKKWRTGILVLVKGTNPEKTIGYRTDIDALPITEETGLPFASKHPGNMHACGHDLHMSIALGVLTHFASKPAKDNLLFVFQPAEEGPGGAKPIMESAEFAEWRPDSIYGLHIAPEYKVGEIAIKPGLLFANTSELFISFKGKGGHAAYPHLANDMVVAASAFVGQMQTIISRNIDPMDSAVITIGRIHGGEIQNVIAETAYLDGTIRTLSPETMEIVWTRLKQLAKGWEEAYQCEVEFHPGSDYYQVDNDPVETEAFIHFLEEQYPESYVPARSAMTGEDFGYFLSEIKGFMFWLGVDSEYSLHHAKLSPKEEAIPFAIDVLIHFLESK
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: RS18_VIBPA
Sequence: MARFFRRRKFCRFTAEGVQEIDYKDVATLKNYITEAGKIVPSRITGTSAKYQRQLARAIKRSRYLALLPYTDKHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: LUXS_VIBA3
Sequence: MPLLDSFTVDHTRMNAPAVRVAKTMQTPKGDTITVFDLRFTAPNKDILSERGIHTLEHLYAGFMRAHLNGSAVEIIDISPMGCRTGFYMSLIGTPSEQQVAEAWLAAMQDVLKVENQNKIPELNEYQCGTAAMHSLDEAKEIANAIIAAGISVNKNDELALPESMLQELKID
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: NUDI_SALA4
Sequence: MRQRTIVCPLIQNDGYYLLCKMADNRGVFPGQWALSGGGVEPGERIEEALRREVREELGEQLILSDITPWTFRDDIRVKTYADGRQEEIYMIYLIFDCVSANRDICINDEFQDYAWVKPEELALYDLNVATRHTLALKGLL
What is the function of this protein?
Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
What are the official names of this protein?
Nucleoside triphosphatase NudI, Nucleotide diphosphatase NudI, Pyrimidine deoxynucleoside triphosphate diphosphatase, dCTP diphosphatase, dTTP diphosphatase, dUTP diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudI subfamily.
Protein: ISPD_YERP3
Sequence: MSNFAVSLPEVIAVLPAAGIGSRMLADCPKQYLTVGGKTIIEHAIFSLLHHPRIQRVIVVIHPQDTQFSRLSVAQDPRISTVYGGDQRANSVMAGLQLAGQAEWVLVHDAARPCLHLDDLSRLLSITECSQVGGILAAPVRDTMKRAEPGIQAIAHTVDRQDLWHALTPQLFPLELLKLCLSRALREGVAVTDEASALEHCGYHPILVTGRSDNIKVTRPEDLALAEFYLTQRQSLNNDSL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: DCUP_BURVG
Sequence: MAHTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKNPDYATEVTLQPLDRFPLDAAILFSDILTIPDAMGLGLDFQAGEGPKFAHPVRTEADVAKLAVPDIDETLGYVTGAVREIRRALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYIRRVVAQLKREHDGERVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGAARERVAGRVALQGNLDPTILFAPPAAVREQARAVLDSYGNHPGHVFNLGHGISQFTSPDHVAELVDEVHGYSRKLRSGAAG
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_CLAM3
Sequence: MPRERGEKVVATNRKARHDYTIESTYEAGLVLTGTEVKSLRQGRASLVDGYAFVDAGEAWLDAVHIPEYNQGTWNNHPVRRKRKLLLHKEQILKIHSKVKEGGYTVVPLQLYFVDGRAKVELAIAKGKKEYDKRQTLRERQDKREADRAMSSHRRLGE
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.