PharMolix/UniProtQA huggingface dataset:
Protein: PTMU_PENSI
Sequence: MSDVNAWWVGGSLLLGIWAIVVFFSPDPLAQYPVINSKRPGELFYTQSKIRFITQARSLLKEGLSKTNNAFRLVTNNRILLVLHSKYRNELRDHKSLNNTKPPEDDFFGWLQGFEPFNHVKTNPKVFAAMVRTKLTPSIGAVGIPLSEETDFVLQQQLTDSPEWHQINVKETSLQLVARLSARIFLGPQVCRNPAWIGIMINYTVEAFMTAERLRMWPRWLLWLVHWFLPSCKKLRSQVQEARGIISQVLQQRERNRKRAFLETEASDEVDTVQWLEDCAKGGYYDPALLQMGLAVVATHTSADLLSQVIFDLCEHPELLQPLREEIVTVITQHGWSKNAIYNLKLLDSVLKESQRLKPMQIISLYRYVTADITLSDGTLIPKGTYIAMIDDHSLDPNSSYTNGDRYDGYRFINMREVPERSHQTQLVSVSSDHTGFGFGNHACPGRFFAATELKIALCHLLLKYDLKLGDQKPQAMTYGFGLSSDPFTQISVRRRQEEISLAGSKS
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).  The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977).  Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977).  Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds.  PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D.  PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively.  PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
What are the official names of this protein?
Cytochrome P450 monooxygenase ptmU, Penitrem biosynthesis cluster 1 protein U.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RISB_MYCPA
Sequence: MSPAAGVPEMPALDASGVRLGIVASTWHSRICDALLAGARKVAADSGVDNPTVVRVLGAIEIPVVAQELARNHDAVVALGVVIRGQTPHFEYVCDAVTQGITRVSLDASTPVANGVLTTDNEQQALDRAGLPESAEDKGSQAAGAALSAALTLRELRARS
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: FRK1_YEAST
Sequence: MSYTNKRHTYYGGFTNDLSDTFQYPQRTDEQRRKHVTFGPYILGSTLGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREINALKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLISGVHYIHSKGLVHRDLKLENLLLDKNENLVITDFGFVNEFCSRNELMKTSCGSPCYAAPELVISAEPYEARKADIWSCGVILYAILAGYLPWDDDPNNPEGSDIGRLYNYINSTPLKFPDYILPIPRDLLRRMLVSDPKKRINLKQIKKHEWLKPHSSFLSITPDEWDKLNNTQSVFRLAKPRRRYGSRPQSSCSTSSLGSRSDKRDSLVIDSTLITFPAPPQESQNHIITRPASIASDQRLSPIRRSNRHNRSNSAASVALQAVVNADREYVLSHEQSLSPVQNIRQTTGNMTASLSPPPAISPGDIIIETTPIKRNTISGSSIVPSLEEESSTTMQTSKIQPNNMASSQNHQYNKNKTQNSLQSAKNFYRTSSSSHTKPRPTSYHPGSYTTPPYNSNTLSIYEINEKAKSSASSQTLNQRDTSPFDSTPYLALDTCITSSSSIESSPKLITHGQFSVAKPSVDLQSVSGDLIKYKRDADVVTRIYDEKYKQKRKSLRYSGIFSDISCDTVTEESDELRPPESPLQQHEGQESIDKAKTEDTSEKGSKSSNIAKATAQKHVNNHLERSLNEAESTKKRFSFLSLYSYDTSKSSLYSSMDSKRKPSPPSQRRPKKDDSYQTNSKNHYITASNMQTSHQVSKDLPAPTMVQNKCTLETKKAVRSNRSSIMVSEVNKASVDNKAAQSPEHSTAKRVLGFFKRRSMKI
What is the function of this protein?
Putative serine/threonine-protein kinase that may be involved in rRNA transcription and ribosome biogenesis.
What are the official names of this protein?
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CI_DROME
Sequence: MDAYALPTYFPLAYSELQFLASRRAAAVAAAATVLPGSPCINQHHPTDVSSSVTVPSIIPTGGTSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHVHNINVTGQPHDFHPAYRIPGYMEQLYSLQRTNSASSFHDPYVNCASAFHLAGLGLGSADFLGSRGLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSDSFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLRASAGLLNPMTPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIPESNRTFGISELNQRITELKMEPGTDAEIKIPKLPNTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQSRRSSQSSQVSSIPTMRPNPSCNSTASFYDPISPGCSRRSSQMSNGANCNSFTSTSGLPVLNKESNKSLNACINKPNIGVQGVGIYNSSLPPPPSSHLIATNLKRLQRKDSEYHNFTSGRFSVPSYMHSLHIKNNKPVGENEFDKAIASNARRQTDPVPNINLDPLTNISRFSTTPHSFDINVGKTNNIASSINKDNLRKDLFTVSIKADMAMTSDQHPNERINLDEVEELILPDEMLQYLNLVKDDTNHLEKEHQAVPVGSNVSETIASNHYREQSNIYYTNKQILTPPSNVDIQPNTTKFTVQDKFAMTAVGGSFSQRELSTLAVPNEHGHAKCESFHHQSQKYMNTDIGSKQQSALPSAHQRQTEKSNYNQIIDSSMTSLPELNVDSIYPRNETENIFKVHGDHDNEIQCGIISQSQMSPSTNLNNDGQFSTVNMQPITTSKLFPPEPQKIVCDTQASNTSVMHLDTYQRTLEYVQSCQNWMETNNTSTNQIQSLPGMPVNNTLFPDVSSSTHPYHGTNMVINDMTTSLTSLLEENRYLQMMQ
What is the function of this protein?
Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway.  The full-length ci form (ciFL), acts as an activator (ciA) while ciR, its C-terminally truncated form, acts as a repressor.  Involved in segment polarity.  Required for the normal development of the posterior half of each embryonic segment.  Engrailed protein directly represses ci expression in posterior compartment cells.  Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
What are the official names of this protein?
Transcriptional activator cubitus interruptus, Transcriptional activator ci, ci form of 155 kDa, ci-155, ci full-length protein, ciFL.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYM_VESOH
Sequence: MTSRKILVTSALPYANGEIHLGHLLEYIQTDIWVRFQKMMGNECHYVCADDAHGTAIMLKADELDITPEVLIKNMSNKHQIDFQSFSIDFSQYHSTHSQENKDISTNIYNKLNVAGFIKTRVISQAFDPLKQMFLADRFIKGDCPKCGSNEQYGDNCEVCGATYSSIELKNAKSVISGVTPITKDSEHYFFDLPQFEVQLKEWTKAGHLQDAISNKLSEWFKEGLQQWDISRDAPYFGFQIPAVEGKYFYVWLDAPIGYMASFKKLCDEQNIDFNEYFNKDSNTELYHFIGKDIIYFHALFWPAMLIGSNYRTPSAIFAHGFLTINGQKMSKSRGTFIQARTYLNYLNPEYLRYYYAYKLSSKIDDIDLNLIDFKQRINSDLVGKVVNIASRSAGFIVKKFNKTLSSYTIESKFYQEFFDCGDIIAKHYEARNYNQAMRVIIKLANKANQYIDKHKPWQLIKKPNQQTQVHDVTSLAINLFRVLMTYLKPVLPIMAKQVEKFLNIDELHWQDLKYPLIKHQINTFKPLMLRIEDDQIERIIEASK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNTB_ECO57
Sequence: MEAIKGSDVNVPDAVFAWMLDGRGGVKPLENTDVIDEAHPCWLHLNYVHHDSAQWLATTPLLPNNVRDALAGESTRPRVSRLGEGTLITLRCINGSTDERPDQLVAMRVYMDGRLIVSTRQRKVLALDDVVSDLEEGTGPTDCGGWLVDVCDALTDHSSEFIEQLHDKIIDLEDNLLDQQIPPRGFLALLRKQLIVMRRYMAPQRDVYARLASERLPWMSDDQRRRMQDIADRLGRGLDEIDACIARTGVMADEIAQVMQENLARRTYTMSLMAMVFLPSTFLTGLFGVNLGGIPGGGWQFGFSIFCILLVVLIGGVALWLHRSKWL
What is the function of this protein?
Zinc transporter.  Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.
What are the official names of this protein?
Zinc transport protein ZntB.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THO4A_XENLA
Sequence: MGDKMDMSLDDIIKLNRSQRPSGRGRGGGRGARGGSARGGAGGRIGGGRGGGAPGVGGPMRSRPVLSRGGRNRPTPYSRPKQLPDKWQHDLFDSGFGAGAGMETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIEAQRRPIQSQSRGGGVTRPRGGTLGFASGNRRGRGGNRGRGRGAGRNPKQQLSAEELDAQLDAYNARMDTS
What is the function of this protein?
Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.
What are the official names of this protein?
THO complex subunit 4-A, Tho4-A, Aly/REF export factor-A.
What is the protein family that this protein belongs to?
Belongs to the ALYREF family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: SF3A1_HUMAN
Sequence: MPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKEGKAQEPSAAIPKVMQQQQQTTQQQLPQKVQAQVIQETIVPKEPPPEFEFIADPPSISAFDLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVMPRPPMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKTEDSLMPEEEFLRRNKGPVSIKVQVPNMQDKTEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGGRKK
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230).  Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277).
What are the official names of this protein?
Splicing factor 3A subunit 1, SF3a120, Spliceosome-associated protein 114, SAP 114.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: MATK_FAGJA
Sequence: MEEFQRYLELDRFRQHDFLYPLLFREYIYALAHDHGFNSYMLLENIGYDNKSSLLIVKRLITRMYQHNYLMISANDSNQNPFFGYNKNLHSQIISEGFAVIVEIPFSLRLISSFEGAEIVISYKLRSIHSIFPFLEDKLPHLNYTTDVRIPYPIHLEILIQTLRSRVKDASYLHLLRFFLHQYSNWNILIITTKSISIFSKSNPRFFLFLYNSHICQYESIFLFLGNQSSHLRLISSGVLFERLYLHKKIEHFAEVFANDFPVIPCFLKDPFMHYVRYQGKSILASKDTPLLMNKWKYYLVNLWQCHFYVWSHPGRIHINQLSKHSLDFWGYFSSVRLNPSVVRSQMLENSFLINNAPKKLDIIVPIIPLIGSLAKARFCNALGHPISKLTRADLSDFEILNRFLRICRNLSHYYSGSSKKKSMYRIKYILRLSCVKTLARKHKSTARAFLKKVGSEFVQEFFTEEEEFLSLIFPRTSFTLRRLYRGRVWYLDIIFINGLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ASR2_SARSH
Sequence: MALAQQFQLNSITFSLLVFLGFVGVSQLIRIYWRLRYIPGPFWAKFTDVQRVFWVQTQRAHEIHRDAHGKYGDIVRFGPNMVSVADPAWIKTIYPMRPGFPKGEFYRALMPYSRQGGALPAVFTTRDENLHKMLKSPVAPLFSLSNVLTLESHVDATIKVLVEQWDRRFLDSQDSIDLADWLSFFAFDVMGTLTFSKRYGFLEEGKDVGGMINTIFTFLKTAAPMTQVPWFDNIWIKNSFAASFRKSNGSSILQIVGKHTSERLKASKSQDMNGSAMSVTKDRDMLDQFIGLAAKNPDLPPWCVTAWTFSNVAAGSDSTAAVMKKVFHSLLSHPNTLQRLMDELIQAQKTNKNMKETPFPSWRDICDLPYLDACILEGIRLHPPFCLPFERVVPKGGIMIGKTYIPEDTLIGMSPWVINHHKPTFGEDAEDWNPNRWMGPEEEKQKREAAILTFGAGKRICLGKQIAMLELKKIVATLLLTYEFEILDPERYEVENWWFFRQHGIDVRVRRRSDKE
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of xenovulene A, an unusual meroterpenoid that has potent inhibitory effects on the human gamma-aminobutyrate A (GABAA) benzodiazepine receptor (PubMed:29773797).  The first step of xenovulene A biosynthesis is the biosynthesis of 3-methylorcinaldehyde performed by the non-reducing polyketide synthase aspks1 (PubMed:17912413, PubMed:29773797, PubMed:20552126).  The salicylate hydroxylase asL1 then catalyzes the oxidative dearomatization of 3-methylorcinaldehyde to yield a dearomatized hydroxycyclohexadione (PubMed:29773797).  The 2-oxoglutarate-dependent dioxygenase asL3 further catalyzes the oxidative ring expansion to provide the first tropolone metabolite (PubMed:29773797).  The cytochrome P450 monooxygenase asR2 allows the synthesis of tropolone hemiacetal (PubMed:29773797).  In parallel, a previously unrecognised class of terpene cyclase, asR6, produces alpha-humulene from farnesylpyrophosphate (FPP) (PubMed:29773797).  The putative Diels-Alderase asR5 probably catalyzes the formation of the tropolone-humulene skeleton by linking humulene and the polyketide moiety (PubMed:29773797).  Oxidative-ring contractions catalyzed by asL4 and asL6 then processively remove carbon atoms from the polyketide to yield xenovulene A (PubMed:29773797).
What are the official names of this protein?
Cytochrome P450 monooxygenase asR2, Xenovulene A biosynthesis cluster protein R2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FLOA_STAA1
Sequence: MFSLSFIVIAVIIIVALLILFSFVPIGLWISALAAGVHVGIGTLVGMRLRRVSPRKVIAPLIKAHKAGLALTTNQLESHYLAGGNVDRVVDANIAAQRADIDLPFERAAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMNGIEVKAKARITVRANIARLVGGAGEETIIARVGEGIVSTIGSSKHHTEVLENPDNISKTVLSKGLDSGTAFEILSIDIADVDISKNIGADLQTEQALADKNIAQAKAEERRAMAVATEQEMKARVQEMHAKVVEAESEVPLAMAEALRSGNISVKDYYNLKNIEADTGMRNAINKRTDQSDDESPEH
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: SOXS_ECO57
Sequence: MSHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL
What is the function of this protein?
Transcriptional activator of the superoxide response regulon of E. coli that includes at least 10 genes such as sodA, nfo, zwf and micF.  Binds the DNA sequence 5'-GCACN(7)CAA-3'.  It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity).
What are the official names of this protein?
Regulatory protein SoxS.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M1_I82A7
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASHTAKAMEQMAGSSEQAAERMEVASQARQMVQAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: PUP_ARTS2
Sequence: MAGQEQQQPQSRESEFEDDAPATPPAPGEAQASAATQGVDDLLDEIDGVLESNAEEFVRAFVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: GREA_BUCAP
Sequence: MINLIPMTVRGAEKLREELEQLKNVKRPRITVQIAEARKHGDLKENAEYHSAREEQSFCEGRIQEIESKLSNSQIIDITKISNDGRVVFGSTVTILNIKNNAVFTYQIVGDDESDFKKNLISINSPMSRGLIGKTVNTIAIIHTPSGNVKYKILKIDYI
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: TRUD_GEODF
Sequence: MHPYLTGNIPGTGGIFKETPEDFLVTEIPIYTPCGEGEHIYAEIEKRGITTLEAIRRLAKALGIGERDVGYAGMKDAKGITRQTISLPRVAPEQVLGLELPGIKVLSAVPHRNKLKVGHLRGNRFRIRIGGVGADAATIAIAVLDILEKRGVPNFFGEQRYGAQGNSHLIGGAILRNDYRGAVDALIGEPDKVTDERWRRAIEAFKAGDLAKSLETFPPHCRTERELLQKLVKQPEAHEKAFRAVHPRLRKLYLSAFQADLFDRVVQQRMDSLDQVVHGDVAFKHDNGACFLVTDAAAEAPRAAAFEISATGPMFGCRMKEPEGETLAMERRLLETEDLTLPSFDLEGGLRMEGERRPLRVPIAEIGVEADGAGLFLEFSLPKGSYATTVLREVMKS
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: SKG1_VANPO
Sequence: MVASNSVAVGCAVGIPVGVGLIIAGCFWLRLQRRFKREDEQDADLQRAVFDEDAYINFESMPTLRNNNNNDEDNNDDKRIKKIEENGNENTIPINDNKEQRKSKYFVPAYRRKINALSVRYDGQQNIEMQGFGANSSKVSLDSSNAPPKRVISVYDQMVPFVDGDKNSVIQNTELLESNDSVGNDSTRPSSQANLISNLNSNDFGSYYPRKESFSSINIPHLNTSSPSFTTRPSSVNSMIRPNSTDNIFDTPRKSNSDIVSINKDQVNRTGSPVKGTVISENMGYKLKNNYNIENSNEIAEEDQYENEFTNYSQNKKEFIDSLRPK
What is the function of this protein?
Plays a role in cell wall integrity.  Affects the cell wall polymer composition in the growing region of the cell (By similarity).
What are the official names of this protein?
Suppressor of lethality of KEX2 GAS1 double null mutant protein 1.
What is the protein family that this protein belongs to?
Belongs to the SKG1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein; Cytoplasmic side. Bud membrane; Single-pass type III membrane protein; Cytoplasmic side. Note=Localizes on the inner surface of the plasma membrane at the bud and in the daughter cell. Localizes at an incipient bud site in the cells with emerging buds, a bud tip in small- or medium-budded cells, and a cell periphery in large-budded cells.
Protein: THIC_METMP
Sequence: MTQMTDAKSGITTEEMKFVAKEEGMDVETLKNLIAKGYVVIPKNVNRNTKPVGIGDNLRTKVNVNLGTSPDFIDIACELKKVEISNKYGADAIMDLSTGGNLPEIRKEIIKNTNLPIGTVPIYEVGVDAKEKYGRVIDMDEDLIFNVIERQAKEGVDFMTLHCGITKQTVSALNNDPRKMGVVSRGGAFLTAYIMYHDKENPLYKEFDYLLELLKEHDVTLSLGDGMRPGCLQDNTDRAQIQELITLGELVDKCREKGVQVMVEGPGHVPYNNIEANMKIQKTLCKNAPFYVLGPIVTDLAPGYDHITAAIGGTLAAVSGANFLCYVTPAEHVRLMKEDDVKEGLIASKIAAQAADVAKGHPVAWKLEKEMADARIKHDWERQFEIALDSNKPRKMREEIPSKDEKACSVCGDYCALLMVEELGKR
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: KYNU_PSEFL
Sequence: MTTRNDCLALDAQDSLAPLRQQFALPEGVIYLDGNSLGARPVAALARAQAVIAEEWGNGLIRSWNSAGWRDLSERLGNRLATLIGARDGEVVVTDTTSINLFKVLSAALRVQATRSPERRVIVTETSNFPTDLYIAEGLADMLQQGYTLRLVDSPEELPQAIDQDTAVVMLTHVNYKTGYMHDMQALTALSHECGALAIWDLAHSAGAVPVDLHQAGADYAIGCTYKYLNGGPGSQAFVWVSPQLCDLVPQPLSGWFGHSRQFAMEPRYEPSNGIARYLCGTQPITSLAMVECGLDVFAQTDMASLRRKSLALTDLFIELVEQRCAAHELTLVTPREHAKRGSHVSFEHPEGYAVIQALIDRGVIGDYREPRIMRFGFTPLYTTFTEVWDAVQILGEILDRKTWAQAQFQVRHSVT
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
Protein: MINC_TOLAT
Sequence: MSERGYELKGSVFTMTVLHLEDAIPEQIQQLLEQKASQAPKFFDSAPLVINVEMLTEIPDFSKIMSAILTANFIPVGVTGVKSNEMREAAKQARLAILTAGKETNTDAVVLHTPKESIYKTPSELREEQQTSPGTTADPDNLVPTKVVQGNVRSGQQIYSPGPVVILGSVSNGAEIISNDSIHVYGTLRGRALAGARGNHDARIFCGHLEAELISIAGHYLLSDSLPEPHVGQEVQISLENEKIIFDKLTS
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: RL15_BUCAK
Sequence: MRLNTLSPAEGAKHAPKRVGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQIPLYRRLPKFGFTSRKAMITAEVRLSELALVEGDVIDLNTLKAANVVGIQIEFVKVILSGEVARPVTLRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.