PharMolix/UniProtQA huggingface dataset:
Protein: HOG1_KLULA
Sequence: MSNEEFIRTQIFGTVFEITNRYTNLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTSVLAKRTYRELKLLKHLRHENLICLEDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVIDTICSENTLKFVTSLPHRDPVPFSSRFQNLEPDAIDLLEKMLVFDPKKRITAADALAHPYLSPYHDPTDEPIAEAKFDWNFNDADLPVDTWRVMMYSEILDFHQIGDPQINTNATFDDQVAAATVAAAEAASKQQQQQQHQTEEQTQQTIASTPPQAQVTPQQLESGANSNSNSNPSFSIGPDPANETLTNFANQADQYVSKFK
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase HOG1, MAP kinase HOG1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RIMK_SHIF8
Sequence: MKIAILSRDGTLYSCKRLREAAIQRGHLVEILDPLSCYMNINPAASSIYYKGRKLPHFDAVIPRIGTAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAHSPDDTSDLIDMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIKEAQGCDIRCLVVGDEVVAAIERRAKEGYFRSNLHRGGAASVASITPQEREIAIKAARTMALDVAGVDILRANRGPLVMEVNASPGLEGIEKTTGIDIAGKMIRWIERHATTEYCLKTGG
What is the function of this protein?
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF).  Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate.  The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
What are the official names of this protein?
Ribosomal protein S6--L-glutamate ligase, Poly-alpha-glutamate synthase, Ribosomal protein S6 modification protein.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: CSN3_DROME
Sequence: MGSALENYVNQVRTLSASGSYRELAEELPESLSLLARNWSILDNVLETLDMQQHSLGVLYVLLAKLHSASTANPEPVQLIQLMRDFVQRNNNEQLRYAVCAFYETCHLFTEFVVQKNLSILGIRIISRAIDQIRQLETQLTPIHADLCLLSLKAKNFSVVLPYLDADITDISTVAAECKTQQQQQSQHADANNDAKYFLLYFYYGGMIYTAVKNYERALYFFEVCITTPAMAMSHIMLEAYKKFLMVSLIVEGKIAYIPKNTQVIGRFMKPMANHYHDLVNVYANSSSEELRIIILKYSEAFTRDNNMGLAKQVATSLYKRNIQRLTKTFLTLSLSDVASRVQLASAVEAERYILNMIKSGEIYASINQKDGMVLFKDDPEKYNSPEMFLNVQNNITHVLDQVRQINKMEEEIILNPMYVKKALGSQDDDLTSQHPKTFSGDPTD
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF.  The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting.  It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
What are the official names of this protein?
COP9 signalosome complex subunit 3, Dch3, Signalosome subunit 3.
What is the protein family that this protein belongs to?
Belongs to the CSN3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RNZ_STAA3
Sequence: MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRSFQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTINVEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKHLANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQTLIQNEDTPNFNFVKDFDSFKI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RL31B_CHLAB
Sequence: MKKNTHPNYQQVLFVDSSTGYKFVCGSTYQSDKTEVFEGQEYPVCYVSVSSASHPFFTGSKRLVDAEGRVDKFLKRYSNVKPAQPAQAAVEEAPAVKSKKKAPIKKKK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: TFDP_DROME
Sequence: MAHSTGGTVKTDEVNFFFRNEHGQISKMLKPAQNKSEMEGGKPVAVVYATGSSARNSGSASGIGNVGRMGAFSQMGSQGQFIRLQDNGLSIPKTEAGTTYTTVSAQKTSGAGSGHYDLPLKGDRYVKFTPNPIKMKSKLHAIQSNSLHSMSASSSSVQRKRKPDKAGKGLRHFSMKVCEKVEEKGKTTYNEVADDLVSEEMKNNAYDNNCDQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLPANSTETFLALEEENCQRRERIKQKNEMLREMIMQHVAFKGLVERNKRNESQGVVPSPNASIQLPFIIVNTHKSTKINCSVTNDKSEYIFKFDKTFEMHDDIEVLKRMGFLLGLDKGECTPENIERVKSWVPPNLAKYVEAYGTGKTGENMYESDDEDNEFNGYLESANESQGFAQHSAQHTTDGEFKLEMDDDELDDDID
What is the function of this protein?
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context.  In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci.  During development, the complex represses transcription of developmentally controlled E2F target genes.  Can stimulate E2F-dependent transcription.
What are the official names of this protein?
Transcription factor Dp.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARLY_PYRIL
Sequence: MSFYRSWIGEEGELIKRYTSSIKDDVEIAEEVIKVMEAHVKHLAEVGIMPKEAADAILKTLKEATPEQLLSSEFEDIHEALEKWLIDRLGEETAGWVGLGRSRNDHVAAAIRLAALRKASALRKNVEKMRCILAKKALEYADCAMPSFTHFQPAQAITFGHYLLAVDELAAEFLHVLKAVEKLLKRSPLGAGPAGGTRTPIDRERLAKLAGFEDVVENALYASGSRFFALALASAVVSFLTELSRTVDDLIRWNSPLVGYVAAPDSHVSTSSIMPHKRNLVTLEVFRARAAEALGHLTALNAVVMKIGLGYSLDLQEATRHLWAVLNMATEGVEIFIDFLEKMSFNCVKAREDAERYHSTSSDTAETIALSGVPFRKAYFQLAKEIKEGTARLMSIEEALQRPTRGSANPEEVKKAASTRLVFCREKPL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTD_SERP5
Sequence: MSHPALFINGAWQQGRGAEFSKTDPVDNQPLWQANAADGSDVAAACEAARAAFPAWARTPFEQREQLVKRFAALLEEHKSHLAATISRETSKPRWETLTEVQAMIGKVAISLQAYQVRTGVSQTAMADGASVLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPQTAEETLKLWQQAGLPDGVINMVQGGRETGEALAASTDIDGLLFTGSAGTGYHLHRQLAGQPEKILALEMGGNNALIVDQIEDCDAAVNLAIQSAFISAGQRCTCSRRILVKRGSEGDAFIERLVQVASALRIGRWDAEPQPFMGGVISSAAAEKMLAAQHHLLSLGGKALLTMQRLESGSALLSPGIIDVTGVRDVPDEEYFGPLTTIIRYNDFDEAVRIANQTRYGLSVGLVSPQRERFDHLLLEARAGIVNWNKPLTGASSAAPFGGVGASGNHRPSAYYAADYCAWPMASLESESLTLPASLSPGLSFN
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: BGL14_ORYSJ
Sequence: MAAAWLVVLLTVHRLLHLSGVSAVDRSQFPPDFLFGTSSSAYQVEGGYLEGNKGLSNWDVFTHKQGTIEDGSNGDTANDHYHRYMEDIELMHSLGVNSYRFSISWARILPKGRFGDVNPDGVAFYNALIDGLVQKGIQPFVTICHYDIPHELDERYGGWLSPEIQKDFSYFAEVCFKLFGDRIKFWTTFNQPNLSIKFSYMDGFYSPGRCSEPFGKCALGNSSIEPYVAGHNIILSHANAVSVYRNKYQGKQGGQIGIALSITWYEPFRNTTIDLLAVKRALSFGASWFLDPILLGDYPTEMREVLGQSLPKFTSKQKNRLQSTKLDFIGLNHYTTCYVKDCIFSPCEIDPVNADARVFSLYERDGVPIGKATGAPFFHDVPRGMEEAVTYYKQRYNNTPTYITENGYSQASNSNMTAKDFTNDTGRITYIQGYLISLASAIRKGADVRGYFVWSLLDDFEWNFGYTLRFGLYHVHYKTLKRTPKLSVDWYRKFLTGSLLRRKFRDESQLHKFNSY
What are the official names of this protein?
Probable inactive beta-glucosidase 14, Os4bglu14.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: GAL1_SALHS
Sequence: MNLKEKTRALFAEIFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRTVRVIAADYDNQVDEFSLDAPIVTHDSQQWSNYVRGVVKHLQQRNNAFGGVDMVISGNVPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRTLGAKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPALRDVSLEAFNAVASELDPVVAKRVRHVLSENARTVEAASALEKGDLQRMGQLMAESHASMRDDFEITVPQIDTLVDIVKATIGDQGGVRMTGGGFGGCVVALIPEDLVPAVRQAVAQQYEAKTGIKETFYVCKPSQGAGQC
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_SYNP2
Sequence: MLDKSEAIIEAIDAREILDSRGRPTVEAEVRLESGAVGLAQVPSGASTGSFEAHELRDGDKARYGGNGVLKAVRNAKEKIAPELIGKDALDQTTVDYAMIARDGSDNKSNLGANAILAVSLAAAKAAAAELALPLYRYLGGPLANVLPVPLMNVINGGAHAANNVDFQEFMIVPVGASSFKEALRWGAEVFTALSKVLDSKGLLTGVGDEGGFAPNLGSNEEALEILVDSIKAAGYEPGTQVALALDIAASEFYADGQYTYDGTAHSPAEFIDYLTAMVEKYPIVSIEDGLHEDDWDSWTILTARIGHRVQLVGDDLFVTNKVRLQQGIEKKAGNAVLIKLNQIGTLTETLETIDLATRNGYQSVISHRSGETEDTTIADLAVATRAGQIKTGSLCRSERVAKYNRLLRIEDELGDRAVYAPKVGLGPQF
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: PSTB_BURO1
Sequence: MNMAESHLNPVERTAAPAGTQDAAHGRPLAPLNAKIEVNNLNFFYNKFHALKNINLRIPEGKVTAFIGPSGCGKSTLLRTFNKMFALYPEQRAEGEILMDGENLLTTKRDISLLRARIGMVFQKPTPFPMSIYDNIAFGVKMFEKLTRSEMDDRVEWALTKAALWNEVKDKLGQSGYGLSGGQQQRLCIARGIAIRPEVLLLDEPCSALDPISTGRIEELIAELKSDYTVVIVTHNMQQAARCSDYTAYMYLGELIEFGETEKIFIKPVRKETEDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
Protein: ECFA2_LEUMM
Sequence: MAINFEQVNFSYGAGTTLAQPILHDINVTIPDGQVTAIIGQTGSGKSTFIQHLNGLLKPTTGRVVIDDFVLTSDLKEKNLTSLRARVGMVFQFPENQLFANTVLEDVMYAPINFGYAKADAEFAAKTALKQVNVSEELWDKSPFELSGGQMRRVAMAGTLASNPDIIVLDEPAAGLDPKGQKELLAIVRGLKEAGKLVVFISHQMDHVIAVADHVIVMHDGGVVAEGTPVEIFNKDLVWFKTVALDLPKAGQFAEQLRQKGHILRHRPLLLTELATMLNEEKRHE
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates including 5-formyltetrahydrofolate, pantothenate and riboflavin.  Expression of the complex plus FolT in E. coli allows 5-formyltetrahydrofolate uptake; 5-formyltetrahydrofolate is not taken up in the absence of FolT or the EcfA1A2T complex.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2, ECF transporter A component EcfA'.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FOSB_STAAM
Sequence: MLKSINHICFSVRNLNDSIHFYRDILLGKLLLTGKKTAYFELAGLWIALNEEKDIPRNEIHFSYTHIAFTIDDSEFKYWHQRLKDNNVNILEGRVRDIRDRQSIYFTDPDGHKLELHTGTLENRLNYYKEAKPHMTFYK
What is the function of this protein?
Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin.  L-cysteine is probably the physiological thiol donor.
What are the official names of this protein?
Metallothiol transferase FosB, Fosfomycin resistance protein.
What is the protein family that this protein belongs to?
Belongs to the fosfomycin resistance protein family. FosB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_STRPD
Sequence: MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFINKELADASVSTIEIERAVNKVIVSLHTAKPGMVIGKGGANVDALRGQLNKLTGKQVHINIIEIKQPDLDAHLVGENIARQLEQRVAFRRAQKQAIQRTMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RS7_SALEP
Sequence: MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAESIVYSALETLAQRSGKSELEAFEVALENVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLANELSDAAENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: DABA_BACC3
Sequence: MSIQSILRKETLKKKDKNIDLQENNINDLVVSASRVIAPLWPISTFAAHHPWMGLEKQSFERVANWLKEARNVDIYPSASMIHSAKAKGEIEESFLQMALSRWLDSQSFHIPRKKVEQFCQAALKLEELPSSLLSSPQLNKLAEEMSYINTESMKDSFLQPVSSFIENQKGENLSDILNYHIIKWCKLYLDDSGSSWTMPNREQGLYRAWHHLIKFDPALSKTERKVLKDWPEDALIALTKALSELGISESNMQAYLEGHLLSLPGWAGMVRWRSQQSIEEQELLIEYLAVRLSMELAVVKPYLPLKNQKVEKKVSIVPLIASWIYWGDISTREWLQMSATEQSELLAFAYRFDENIRKKLWLEAWEQTHAEQLKKKISSKQRATNDKKRVVAQLAFCIDVRSEPFRRHLEKLGPFETFGIAGFFGLPIATTELGSNDSHPSLPVILKPKHQIKELTDENECKSYEQRKMVGSSVRYTFKTMKQNVLTSMLLPEVSGPLLGLQMVTRSFVPRRVGGFIRNLRKNMLQKPDTTFSLNHVHDTNCEIPIGFTKEEKVNYVRQALKMVGLTEGFAPLVVMCGHSSQSTNNPYAAALECGACGGAAGGFNARVFATLCNLPEVREALSAEGIKIPDDTIFAAAEHKTTVDELEWIYVPELSETAQEAFDCIEAIMPNVSQHANRERLMQLPNFKTKIKNPSKEAHRFAEDWSEIRPEWGLARNASFIIGQRELTQDCDLEGRAFLHNYDWKQDERGDILANIIAGPGTVAQWINLQYYASTVAPHYYGSGNKTTQTVTAGLGVMQGNASDLLPGLPWQSVMQSDRETYHSPLRLLIVIQAPTKYIEHLLNNDFTFREKVQNGWVRLASVDPEGRWKNW
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ATPG_MARMS
Sequence: MAVGKEIRTQISSINNTRKITRAMEKVAASKTRKAQDRMAASRPYAERIRQVVGHLANANPEYKHRYLTEREAKRVGYIVISSDRGLCGGLNVNVFKKAIRDMKQFADTGVEIDICAIGSKAVSFFRNYGGNVTAAHTGLGDAPKADDLVGSVKVMLDAFDEGRIDRLYVVSNEFVNTMTQNPTVEQLLPLKAEENTELKHHWDYIYEPEAVEILDELLVRYIESQVYQSVVENIACEQAARMLAMKNATDNAGDIIDELQLVYNKARQAAITQEISEIVSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KINI2_PERAM
Sequence: DASFSSWG
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Kinin-2, Pea-K-2.
What is the protein family that this protein belongs to?
Belongs to the kinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: OS24_PLABA
Sequence: MNFKYSFIFLFFIQLAIRYNNAKITVDTICKGGKLIQMSNHYECKCPSGYALKTENTCEPIVKCDKLENINKVCGEYSICINQGNFGLEKAFVCMCTNGYMLSQNICKPTRCYNYECNAGKCILDSINPNNPVCSCDIGKILQNGKCTGTGETKCLLKCKAAEECKLTGKHYECVSKPQAPGTGSETPSNSSFMNGMSIISIIALLVIYVIVM
What are the official names of this protein?
24 kDa ookinete surface protein, Pbs21.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: TGT_SHESW
Sequence: MKFELDTTDGRARRGRLIFDRGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFLDPEKSMQIQDALGSDVVMIFDECTPYPATEDEARKSMQMSLRWAKRSRDEFDRLKNPNSLFGIIQGGVYEDLRDESLKGLVEIGFDGYAVGGLAVGEPKADMHRILEHICPQIPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFTSEGVIKIRNARHRDDTSPLDTKCDCYTCKNYSRAYLYHLDRCNEILGARLNTIHNLRYYQMLMEGLRGAIETGTLDAFVADFYTSQGREVPELVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NLTPB_RICCO
Sequence: VNCGQVNKALSSCVPFLTGFDTTPSLTCCAGVMELKRLAPTVKDKRIACECVKTAAARYPNIREDAASSLPYKCGVVINVPISKTTNCHEIN
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
What are the official names of this protein?
Non-specific lipid-transfer protein B, NS-LTP B, Phospholipid transfer protein, PLTP.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: RLMKL_ACIAD
Sequence: MNSPQRLSTYWVTCADGLETLLQQELQGLGIEQTERFAGRLIFQGSLEQAYRVCMWSRLASRVLKPIHTFELERTHDARDVAEELYEGALSFDWSLIFAPQSTFAIRLHVEREIKVNSQFATLRVKDGVVDSFMEAVGRRPSIDTKQPEITLFVLAGKTEHTYCLDLSGDSLHKRGYRHYMTDAPIKENLAAAILQKAKLTELKPDLILDPMCGSGTFIIESLMIFTDRAPGLVRRFGFNGWHGHDRELWLELKAEAAERHEIALQNTLPKFYAFDADWEAVKATRQNIIAAGFEKLLDQIQIEERTLADWPSFENTYNTAFVVTNPPYGERLGDKASNRALYLGLSALLQQYFPKQHAAVIAAQIEQADVLAFSEPETLRLMNGKLPIYIRLGQVKPVANSQPFLANWHADPVEIEGAQDFANRLQKNMSALKKWAVKDQVFCLRLYDADLPDFNVAVDLYGDRLHVQEYAPPKTIDPEKAKKRFNLALAAIRAVTGLPREAIFIKTRARQEGKNQYTKQSTASKRFIVQEGQAKILVNLTDYLDTGLFLDHRQIRLRIAQEARGKHFLNLFSYTSTASLHAALGGAASTTSVDLSNTYINWSKENFVLNGLTVDHADEQHMFFASDCFEWLKEGHEQYDLIFIDPPTFSNSKKFYGTFDIQRDHVSLLKRAMNRLSAEGTLYFSNNYRGFELDEEIDAIFYAQEITNDTIGPDFKRNQKIHRAWKIQHPHMN
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_BREBN
Sequence: MSLFDKRLSEIHSALRAKEISVTDLVQASIASIKEHDGEIKSVLHVDEEGALAHARQLDERLVKGNEELGLLYGLPAGLKDNLVTKDIRTTCASKFLANYDPVHDGTVSKKVKDADSVIVAKLNMDEFAMGGSNENSGFFPAKNPWNTDYVPGGSSGGSAAAMAARHFYYTLGSDTGGSIRQPAAFCGVVGLKPTYGRVSRFGLVAFASSLDQIGPVTKNVEDSAYVLQAIAGHDEYDSTSANVDVPNYLSALTGDVKGLRIGVPKELIGEGIDPEVRDAVLAALKQLESMGATWSEVSMPHTEYAVPAYYLLSSSEASSNLARFDGVRYGVRADNAANLIELYKESRSQGFGQEVKRRIMLGTYALSSGYYDAYYKKAQQVRTLIIQDFNSIFADYDVILHPTTPSTAFKVGENVDDPVKMYLEDICTVPVNLAGLPAISVPCGFSKNGLPIGLQIVGRAFDESTVLRVAHAYEQTAGFYGRKPEWVRG
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: GUAC_STAA3
Sequence: MKIFDYEDIQLIPNKCIVESRSECDTTIQFGPKKFKLPVVPANMQTVMNEKLAKWFAENDYFYIMHRFDEEARIPFIKHMQNSGLFASISVGVKKAEFDFIEKLAQEKLIPEYITIDIAHGHSDSVINMIKHIKTHIPDSFVIAGNVGTPEGVRELENAGADATKVGIGPGRVCITKIKTGFGTGGWQLAALNICSKAARKPLIADGGIRTHGDIAKSIRFGASMVMIGSLFAAHEESPGETVELDGKQYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLMDTLKEMQQDLQSSISYAGGKDLKSLRTVDYVIVRNSIFNGDRD
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: HDP_PLAF7
Sequence: MKNRFYYNLIIKRLYTRSGGLRKPQKVTNDPESINRKVYWCFEHKPVKRTIINLIYSHNELKIFSNLLNHPTVGSSLIHELSLDGPYTAFFPSNEAMQLINIESFNKLYNDENKLSEFVLNHVTKEYWLYRDLYGSSYQPWLMYNEKREAPEKLRNLLNNDLIVKIEGEFKHCNHSIYLNGSKIIRPNMKCHNGVVHIVDKPIIF
What is the function of this protein?
Heme detoxifying enzyme that converts heme to crystalline hemozoin (beta-hematin) to protect the organism from the toxic effects of heme (PubMed:18437218, PubMed:23471987, PubMed:25138161, PubMed:28949547).  During its development, P. falciparum proteolyzes vast amounts of host hemoglobin, leading to heme release (PubMed:18437218).
What are the official names of this protein?
Heme ligase, Heme detoxification protein, PfHDP, Hemozoin synthase.
What are the subcellular locations of this protein?
Vacuole. Host cytoplasm, host cytosol. Note=Delivered to the food vacuole, the site of hemozoin formation, via a unique trafficking route (PubMed:18437218, PubMed:23471987). Initially secreted into the cytosol of infected red blood cells (PubMed:18437218). A subsequent endocytosis of host cytosol delivers HDP to the food vacuole (PubMed:18437218).
Protein: MURD_OCEIH
Sequence: MNVLTNFPYQHVLVLGLAKSGTAAANVLLQNHIQVTINDGMATLEDATVQKLQTMGAELVLGSHPISVLDGKDLIVKNPGIRYDNVIVEEAQRRGIPVISEVELVHYLTNQPVIGITGSNGKTTTTTLITEMLDRSNVSVKVAGNIGVVATEVASSLQSDEKMVMELSSFQLQGIDQLQFSTAVLLNLFEAHLDYHGSFENYVEAKCNIFKSQNKHDYLIYNADDDNVSAAIKTAEATKVPFSSSRPLADGAWMDDDFLYYKDEKIIAIRDIVLVGKHNMENILAAIATAKLNGATNEGIVQVLTTFSGVKHRLEFVGVINGRYIYNDSKATNILATKKALAAFNKNVVLLAGGLDRGNTFEELIPYLHHVKAMVVFGETAGKLKDAGVAANIPVIEKALDVQHAVEVAFALTDEQDTILLSPACASWDQYKTFEERGDMFIQALHRLK
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.