PharMolix/UniProtQA huggingface dataset:
Protein: PHE3_RHDS2
Sequence: MFAKTLASLAVIGSAAAYVPMMSMDMGRREVVQAGAAAAAVTPFLSGAPAGAAMDKSAKAPQITIFDHRGCSRAPKESTGGKAGGQDDEMMVKVASTKVTVSESDAAKKLQEFITFEKGIDGPFTSKN
What is the function of this protein?
Light-harvesting photosynthetic tetrapyrrole chromophore-protein from the phycobiliprotein complex.
What are the official names of this protein?
Phycoerythrin alpha-3 chain, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the phycoerythrin family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side.
Protein: UBIQD_DICDI
Sequence: MQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGL
What is the function of this protein?
Ubiquitin exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin-D.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RRP40_YEAST
Sequence: MSTFIFPGDSFPVDPTTPVKLGPGIYCDPNTQEIRPVNTGVLHVSAKGKSGVQTAYIDYSSKRYIPSVNDFVIGVIIGTFSDSYKVSLQNFSSSVSLSYMAFPNASKKNRPTLQVGDLVYARVCTAEKELEAEIECFDSTTGRDAGFGILEDGMIIDVNLNFARQLLFNNDFPLLKVLAAHTKFEVAIGLNGKIWVKCEELSNTLACYRTIMECCQKNDTAAFKDIAKRQFKEILTVKEE
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  RRP40 as peripheral part of the Exo-9 complex is thought to stabilize the hexameric ring of RNase PH-domain subunits.
What are the official names of this protein?
Exosome complex component RRP40, Ribosomal RNA-processing protein 40.
What is the protein family that this protein belongs to?
Belongs to the RRP40 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: ARLY_HAEI8
Sequence: MALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIQGSIGWSKALVKVNVLTVEEQHQLEQALNELLVEVRSNPQAILQDDAEDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVAVDIKLWCKQRVVELQESVRNLQRHLVQTAENTQQAVMPGYTHLQRAQPITFAHWCMAYVEMFDRDYSRLTDAYNRMNTCPLGSGALAGTAYAVDRDSLAHDLSFAFATRNSLDSVSDRDHIVELLSIASLSMAHLSRFAEDMIIFNSGEANFVELSDRVTSGSSLMPQKKNPDACELIRGKTGRVIGSLTSMLITLKGLPLAYNKDMQEDKEGIFDALDTWQNCVDMATFVLDELKVNVERTREAALKGYSNATELADYLVSKGVPFRDSHHIVGETVVYAIEKGKGLEDLTIPEFRQFSEVVGDDVYEILSLQSCLDKRCAKGGVSPLRVAEAIAEAKTRFA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAJ_PLETE
Sequence: MTNFTTYLSTAPVVALIWFTFTAGLLIEINRFFPDPLVFSF
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SSR3_RAT
Sequence: MAAVTYPSSVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQPGPSGQQQRPCTGTAKEQQLLPQEATAGDKASTLSHL
What is the function of this protein?
Receptor for somatostatin-14 and -28.  This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
What are the official names of this protein?
Somatostatin receptor type 3, SS-3-R, SS3-R, SS3R, SSR-28.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
Protein: CPRP_CANPG
Sequence: RSAQGMGKMERLLASYRGALEPSTPLGDLSGSLGHPVE
What are the official names of this protein?
CHH precursor-related peptide, CPRP.
What are the subcellular locations of this protein?
Secreted.
Protein: RL23_BORBU
Sequence: MKAYDIIVSPMLTEKTNTQRESINVYVFKVNKRANKKEVGAAIKELFNVTPVSCNLLNIKSKAKVVVSRKGYPIGKGKTSSWKKAYVYLKKEDKIDIF
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: ILVD_STRPI
Sequence: MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDIIADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKDIDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIEAAGRAVVKMLELGLKPSDILTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLLANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDGAVAKVSGVKVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWNMDKSGKK
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PROA_CERS1
Sequence: MDGTDVTMLMREIGVRARAAAAELAFAEPSRKEEALNAAAEAMLARSDEILEANGRDLAFGAEKGLTPAMMDRLKLDAARIDGIVEGLRAVAGQPDPVGQVIAEWDRPSGLHIRRVRTPLGVVGVIYESRPNVTADAGALCLKSGNAVILRGGSESFHSSGAIHAALQDGLRQAGLPVDAIQRVPTRDRAAVAEMLRMVEHIDVIVPRGGKGLVGLVQAEARVPVFAHLEGICHVYADGDADLEKARRVVLNAKTRRTGICGSAECLLIDRAFLAKHGPVLIEDLLKAGVEVRAEGELAQVPGTVPAQPEDFGREFLDMIIAAKVVDGVDEAIAHIRRYGSSHTESILTENDATAERFFRRLDSAILMRNASTQFADGGEFGMGAEIGIATGKMHARGPVGAEQLTSFKYLVTGDGTIRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_NATTJ
Sequence: MFKLNDEKGRLKCSFCGKTQEQVKKLVAGPGVYICDECIELCNEIIEEELNDDSDMGFSEIPKPQEIYEILNDYIIGQEEAKKALSVAVYNHYKRVNNEAKKKDDVEIQKSNILLLGPTGVGKTLLAQTLAKILNVPFAMADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIVYIDEIDKVARKTDNPSITRDVSGEGVQQALLRILEGTKASVPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIDKIIQNRIGKKGLGFGAEVQSAKDEGIGEILSKVLPQDLLKFGLIPEFVGRIPVISSLDALDEDALVRILVEPKNALVKQYQKLFEIDGVELEMQEDALRAIAREAIERNTGARGLRAIVEEHLNDIMYDLPSMDDVNKCIITEEVIEKDERPMLVKDNQGEKKHESA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: BRRF2_EBVB9
Sequence: MSGQQRGSVILVPEHLAGALTKLMSDFITGQDVTLSGGNIAVKIRDAINQTPGGGDVAILSSLFALWNALPTSGRQSSRDDLIPAAVQALTTAHNLCLGVIPGETSHKDTPESLLRAIVTGLQKLWVDSCGCPECLQCLKGLKAIKPGLYEIPRIIPHTKQCSPVNLLNMLVHKLVALRGHVQLAYDARVLTPDFHEIPDLDDSDAVFARTLLAALFHLNMFFILKDYITQDSMSLKQALSGHWMSATGNPLPAAPETLRDYLEAFRNSDNHFYLPTTGPLNTFQFPEELLGRVVVIDSSLCAASHVQDVITHGVGAGVPRPRFSALPPAPSREPQQTCSQLTSRGNESSRRNLGQPGGTSPAVPPVCPIVSLTASGAKQNRGGMGSLHLAKPEETSPAVSPVCPIASPAASRSKQHCGVTGSSQAAPSFSSVAPVASLSGDLEEEEEGSRESPSLPSSKKGDEEFEAWLEAQDANLEDVQREFSGLRVIGDEDEDGSEDGEFSDLDLSDSDHEGDEGGGAVGGGRSLHSLYSLSVV
What are the official names of this protein?
Tegument protein BRRF2.
What is the protein family that this protein belongs to?
Belongs to the lymphocryptovirus BRRF2 family.
What are the subcellular locations of this protein?
Virion tegument.
Protein: ARF3_ARATH
Sequence: MGILFTRMFSSVFGNKEARILVLGLDNAGKTTILYRLQMGEVVSTIPTIGFNVETVQYNNIKFQVWDLGGQTSIRPYWRCYFPNTQAVIYVVDSSDTDRIGVAKEEFHAILEEDELKGAVVLIFANKQDLPGALDDAAVTEALELHKIKSRQWAIFKTCAVKGEGLFEGLDWLSNTLKSGSG
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor 3, AtARF3, Protein ARF-LIKE 1, AtARL1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: LEUC_SYNR3
Sequence: MSTATLYDKVWALHQVAELPSGSTQLFIGLHLIHEVTSPQAFAALKDLGLSVRHPERTVATVDHIVPTTSQARPFADGLAEEMLSTLERNCHENGIHLNGLGSGRQGIVHVMAPELGLTQPGMTVACGDSHTSTHGAFGAIAFGIGTSQVRDVLASQSLTMNKLKVRRIWVDGALQPGVFAKDLVLHIIRTLGVKGGVGYAYEFAGPAIEALSMEERMTLCNMAIEGGARCGYVNPDQTTFDYLKGRPHAPSGDAWDHAVSWWKSLASGADACFDDEVKFDAAVIAPTITWGITPGQGIGVDEAVPTLEQTPEEDRPLAQEAYRYMDLQPGQAIAGLPVDVCFIGSCTNGRLSDLRAAAAVAAGRQVASGIKAFVVPGSEQVAAAAEAEGLDAVFRQAGFEWREPGCSMCLAMNPDRLEGRQISASSSNRNFKGRQGSASGRTLLMSPAMVAAAAIAGRVTDVRSLPPA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: NUSB_CLOBA
Sequence: MNRKLSREKAMELLFGMTLNTDNCEETLGNFIDNYESDIKELDITYIKRILIGVENNKDNIDEAISKNLCNWKIDRISKVNLCILRLAVYELLHDEEIPNRVAINEALEITKKYSDEKSVSFINGVLDNILKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: SYC_EHRRG
Sequence: MIIYNTLTRSKELFVPLDVNNVKIYVCGPTVYDFAHIGNSRSIVIYDILFRLLNVLYPKVTYIRNITDIDDKIINVAQNNNQNIYDVTARYIKAFNEDMGRLNCLKPTYEPRATENIDVMLALIEKLINYGHAYIRDNTVFFDIQSYPAYGKLSGRNIMELIYGSRIDIEVGKKHPGDFVLWKPATDIDSKLMSCWPSPWGVGRPGWHIECSAMSYNYLGENFDIHGGGADLQFPHHENELAQSCCAFPNSYYAKYWIHNGFLTVNHEKMSKSLGNFLTVRQLLDSGIRGEVIRYIFLSTHYRKPLDWNDNVVSSAQESLNRIYMALNVTDERLLLDDVEVSDEIISCLKDDMNTPKAIAVLHEMVTRINKASDIDKKVYFIKVLIKSANFLGILHHSWQEWFKVDNDQDIIQLIHERKMAKTNGDFIKADRIRQILLDKGIVLSDNKDGTTLWYRS
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIAE_HUMAN
Sequence: MVAPGLVLGLVLPLILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLEKINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSAVCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINYNTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFGSIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSLTLAIDSCHGTVVALRYAWTTWPCEYKQCPLYHPSSALPAPPFIAFITDQGPGHQSNVAK
What is the function of this protein?
Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
What are the official names of this protein?
Sialate O-acetylesterase, H-Lse, Sialic acid-specific 9-O-acetylesterase.
What are the subcellular locations of this protein?
Lysosome. Secreted.
Protein: POXIN_NPVOP
Sequence: MYIKMEVEFDEDTGALQIGGQEVFVMVFEPGQEVFDKSLDQHHQFPGVATSVVFPQLSIGTKVDVFTSSGGFGATDHHCFNYHVCNKRFVFGSVPALEIPADVREHLRIGAPITCADRLVSLVTAVHAADGAWLLRVTAARAGQVSGHARQQRRGAGRTVRAGRSVYGPVQLPYEQLKAHAFRKRRPRRDAAESCALFYNDSEVRITFNKGEFELMHWRLPGPLVSHGFK
What is the function of this protein?
Nuclease that cleaves host 2',3'-cGAMP.
What are the official names of this protein?
Poxin.
What is the protein family that this protein belongs to?
Belongs to the poxin family.
Protein: RL36_BACC2
Sequence: MKVRPSVKPICEKCKVIRRRGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: YAEP_ESCF3
Sequence: MEKYCELIRKRYAEIASGDLGYVPDALGCVLKVLNEMAADDALSEAVREKAAYAAANLLVSDYVNE
What are the official names of this protein?
UPF0253 protein YaeP.
What is the protein family that this protein belongs to?
Belongs to the UPF0253 family.
Protein: LPXK_SALNS
Sequence: MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGFKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEKLQQRGVRVGVVSRGYGGKAAAYPLLLTPETTTAEAGDEPVLIYQRTGAPVAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEIVVIDGVRRFGNGWWLPAGPMRERASRLKTVDAAIVNGGVARAGEIPMQLAPGLAVNLRTGARCDVAQLSNIVAMAGIGHPPRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCCAFAEDNWWFLPVDARLSGEQPDKLLEHITSLVR
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: KCNAS_DROME
Sequence: MAAVAGLYGLGEDRQHRKKQQQQQQHQKEQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQQQQNGFKQQQQQTQQQLQQQQSHTINASAAAATSGSGSSGLTMRHNNALAVSIETDV
What is the function of this protein?
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.  The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.  Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A-type currents (PubMed:2448636).  Plays a role in the regulation of sleep need or efficiency (PubMed:15858564).  Plays a role in sexual behavior, where it is important for male sex discrimination (PubMed:22292044).
What are the official names of this protein?
Potassium voltage-gated channel protein Shaker, Protein minisleep.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Shaker sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SHLB1_RAT
Sequence: MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKVWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETKSSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYVSNNNQTSGTPVPYTLSNTIGPSAVASTGSLVITCPPNLSDLKDSSSTRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN
What is the function of this protein?
May be required for normal outer mitochondrial membrane dynamics.  Required for coatomer-mediated retrograde transport in certain cells.  May recruit other proteins to membranes with high curvature.  May promote membrane fusion.  Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation.  Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy.  Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2).  Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation.  Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).
What are the official names of this protein?
Endophilin-B1, SH3 domain-containing GRB2-like protein B1.
What is the protein family that this protein belongs to?
Belongs to the endophilin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane. Midbody. Note=Association with the Golgi apparatus depends on the cell type. Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes.
Protein: PYRR_CLOPE
Sequence: MHLKASLLDENAIRRALTRLSHEIIEKNKGVEDIVLVGIKRRGYPLAERLSEFIEKFEGVKIPVASVDITLYRDDLTNVSDTPNLNDPKIDVDIRGKKVIIVDDVLYTCRTARAAIDAIMDQGRPEFIQLAVLVDRGHKELPIRADYVGKNIPTSKDEIIKVQIKEIDGTDSVEIYEN
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: Y1335_YERE8
Sequence: MTTKPSDSVSWFQVLQRGQHYMKTWPADKRLAPVFPENRVATATRFGIRFMPPLAIFTLTWQIALGGQLGPAIATALFACGLPLQGLWWLGKRAITPLPPTLLQWFHEVRNKLAEAGQAVAPVEQTPTYQSLADVLKRAFKQLDKTFLDDL
What are the official names of this protein?
UPF0208 membrane protein YE1335.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL4_NATPD
Sequence: MKATVRDLDGDDAGEVELPAVFETDYRPDLIKRAVLAAQANRIQDTGTDEYAGLRTPAESPGSGRGMAHVPRQNGRAREVPQAVSGRPAHPPKAEKDRGLDINTKERKLATRSAIAATANADRVEERGHEFDEETDLPLVVSDEFEDLVKTQEAVDVLEALGVYDDIERAEDGKTVRAGRGTTRGRKYTEPKSVLVVTSDDQSLAARNLAGSDVATADEVNVEDLAPGTQAGRLTLWTESALAEVAER
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ALR1_STAAN
Sequence: MSDKYYRSAYMNVDLNAVASNFKVFSTLHPNKTVMAVVKANAYGLGSVKVARHLMENGATFFAVATLDEAIELRMHGITAKILVLGVLPAKDIDKAIQHRVALTVPSKQWLKEAIKNISGEQEKKLWLHIKLDTGMGRLGIKDTNTYQEVIEIIQQYEQLVFEGVFTHFACADEPGDMTTEQYQRFKDMVNEAIKPEYIHCQNSAGSLLMDCQFCNAIRPGISLYGYYPSEYVQQKVKVHLKPSVQLIANVVQTKTLQAGESVSYGATYTATDPTTIALLPIGYADGYLRIMQGSFVNVNGHQCEVIGRVCMDQTIVKVPDQVKAGDSVILIDNHRESPQSVEVVAEKQHTINYEVLCNLSRRLPRIYHDGDQRFVTNELLK
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase 1.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: MUTS_ALIF1
Sequence: MAIKSTEKHTPMMQQYLRLKSENPDILLFYRMGDFYELFYDDAKRASQLLEISLTKRGSSAGEPIPMAGIPYHAVEGYLAKLVQQGESVAICEQVGDPATSKGPVERKVVRIVTPGTVTDEALLPERFDNLIAAIYHHKGQFGYATLDITSGRFKVSEPNTEEAMLAELQRTAPTELLFSEDFEPVHLLEKRNGNRRRPVWEFELDTAKQQLNNQFGTRDLVGFGVEKAEFGLCAAGCLIQYVKDTQRTTLPHIRSIIMDHQDDSVILDAATRRNLEITQNLAGGFNHTLAEILDHTSTAMGSRLLKRWLHQPVRTHDVLNQRLDAIGELKESGLFADMAPQLKNIGDVERILARLALRSARPRDLARLRNALQQLPELSQTTQEFQQDHLLTLAASAQPIDSICELLERAIKENPPVVIRDGGVLADGYNEELDQWRDLANGATQYLEKLEQEERERHDIDTLKVGYNNVHGFYIQISKGQSHKAPAHYVRRQTLKNAERYIIPELKEHEDKVLNSKSKALAIEKRLWEELFDQLLPHLEQLQSMANAISELDVLSNLAERADTLNYCRPVLTKETGINIEGGRHPVVEQVMSDPFIANPIKLNPDRKMLIITGPNMGGKSTYMRQTALIALMAHVGCYVPADSAEIGTLDRIFTRIGASDDLASGRSTFMVEMTETANILHNATKHSLVLMDEIGRGTSTYDGLSLAWASAEWLATKINAMTLFATHYFELTELPNLFTGLANVHLDAVEHGDEIAFMHAVQEGAANKSYGLAVASLAGVPKSVIKKAKQKLQHLESGQVPVPATSTTVKEEHQLSLIPEISEVEEALAHVNPDDLTPRQALEELYRLKALL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RL21_LACAC
Sequence: MYAIIKTGGKQYKVAEGDSVFVEKLDAAEGSEVTFDEVILVANGDDVKVGTPLVDGAKVTAKVEKQGKEKKVVTFKYKPKKHSHSKYGHRQPYTKVTVEKIEA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.