PharMolix/UniProtQA huggingface dataset:
Protein: SFSA_PSEAE
Sequence: MRFEQPLEEGRLLRRYKRFLADIESAGGERLTIHCPNTGSMLNCMSEGCRVWFSRSNDPKRKLPGTWELSETPQGRLACVNTARANRLVEEALLAGDIAELAGFTALRREVAYGVENSRADFRLEYPTGALFIEVKSVTLGFDETAVAAFPDAVTLRGAKHLRELAALAREGIRAVQLYCVNLSGVEAVRPADEIDPAYGKALREAAQAGVEVLAYGAEVTTEGLNLARRLPVRL
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: RRF_PROMM
Sequence: MSNQELKDNMHKSVEATQRNFATIRTGRANPSLLDRINVEYYGTETPLKSLATISTPDSQTIAIQPFDNGSMGLIEKAIATSDLGLTPNNDGKIIRINVPPLTEERRKEFCKLAARYAEEGKVALRNIRRDAIDKVKKLEKDAELSKDQSHDEQDGIQKLTDTFITEIEKYLAEKEADILKV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_ECOL6
Sequence: MSLTRLLIRDFRNIETADLALSPGFNFLVGANGSGKTSVLEAIYTLGHGRAFRSLQIGRVIRHEQEAFVLHGRLQGEERETAIGLTKDKQGDSKVRIDGTDGHKVAELAHLMPMQLITPEGFTLLNGGPKYRRAFLDWGCFHNEPGFFTAWSNLKRLLKQRNAALRQVTRYEQLRPWDKELIPLAEQISTWRAEYSAGIAADMADTCKQFLPEFSLTFSFQRGWEKETEYAEVLERNFERDRQLTYTAHGPHKADLRIRADGAPVEDTLSRGQLKLLMCALRLAQGEFLTRESGRRCLYLIDDFASELDDERRGLLASRLKATQSQVFVSAISAEHVIDMSDENSKMFTVEKGKITD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP (By similarity).
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPX1_ARATH
Sequence: MSDLDRQIGQLKRCEPLSESEVKALCLKAMEILVEESNVQRVDAPVTLCGDIHGQFYDMMELFKVGGDCPKTNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSSNVWRYCTDIFDYMSLSAVVENKIFCVHGGLSPAIMTLDQIRTIDRKQEVPHDGAMCDLLWSDPEDIVDGWGLSPRGAGFLFGGSVVTSFNHSNNIDYIARAHQLVMEGYKWMFDSQIVTVWSAPNYCYRCGNVASILELDENLNKEFRVFDAAQQDSRGPPAKKPAPDYFL
What are the official names of this protein?
Serine/threonine-protein phosphatase PP-X isozyme 1.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
What are the subcellular locations of this protein?
Plastid stroma.
Protein: LEPA_XANCP
Sequence: MSSDSMRNIRNFSIIAHVDHGKSTLADRIIQLCGGLQAREMEAQVLDSNPIERERGITIKAQSVSLPYTAKDGQTYFLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAAQGVEAQSVANCYTAVEQGLEVVPVLNKIDLPTADIERAKAEIEAVIGIDAEDAVAVSAKTGLNIDLVLEAIVHRIPPPKPRDTDKLQALIIDSWFDNYLGVVSLVRVMQGEIKPGSKIQVMSTGRTHLVDKVGVFTPKRKELVALGAGEVGWINASIKDVHGAPVGDTLTLAADPAPHALPGFQEMQPRVFAGLFPVDAEDYPDLREALDKLRLNDAALRFEPESSEAMGFGFRCGFLGMLHMEIVQERLEREYNLNLISTAPTVVYEVLKTDGTIIPMDNPSKLPPLNHVEEIREPIIRANILTPPDYVGNIITLCEEKRGSQIGINYLGSQVQISYELPMAEVVLDFFDKLKSVSRGYASLDYHFLRFQVGPFVRVDTLINGDKVDALSIIVHRSYADRRGRELCEKMKELIPRQMFDVAIQAAVGSQIISRSTVKAMRKNVLAKCYGGDVSRKKKLLEKQKEGKKRMKQVGRVEIPQEAFLAVLQMDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GLOO_GLAL2
Sequence: MIAALFTTNLQLGAVGVFIFALLAFAFNKLTTWEYSIPKEVQWVDRRTQPFSYLRAKARALARSKENTLEAYFRFNKLGKAAALAVPFGRPLLLLPQTFVRWIVDQPESIISLDPIHDDFHVFVGGDLTGDHTVQELLRRELTLNLDKLISVINDEIVCALDDVLGNSPEWKSTSLADDLKTIVARTSNRVFVGKDLCRNKHYISTVKGLALVIMPETVLQDLIPQFLKGPLSRITKAFNNIYGMKKFSSLLLGVVRQRYIDVKDVLEGSGDKTRLPDDLLTWMVQKSIRKGESSANIDKLLVARIAMANLAAIETTTAAMTRSVLDLVTQGSEGGFLKAVQEETLAVVEGCNYEPSKKDVLKLVLTENAIKEALRLQVAFPGLMRQVVAPNGVTLENGLHVPCGTRLGVSAAGIHVDESIYEDPTTYNPGRFLVRDLDPRGDPSPMWKGNENYLAFSLGRRSCPGRWYVTDQLKLTLAHIFSKYEIRFEKAAETASALRKILPGAPQDRVMIRRRSVGKR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non-competitive inhibition of beta-1,3-glucan synthase (PubMed:27705900).  The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4 (PubMed:27494047).  The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain (PubMed:27494047).  The 10R,12S-dimethylmyristic acid is then transferred to the first thiolation domain of the nonribosomal peptide synthetase gloA/GLNRPS4 by the acyl-AMP ligase gloD/GLligase, followed by its acylation to L-ornithine to trigger elongation of the cyclic hexapeptide (PubMed:27494047).  L-ornithine, 4R-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2), 3S-hydroxyl-L-homotyrosine (generated by gloG/GLHtyB, gloH/GLHtyA, gloI/GLHtyC, gloJ/GLHtyD and hydroxylated at C-3 by the dioxygenase gloM/GLOXY1), 3R-hydroxyl-L-glutamine (generated from L-glutamine probably by the dioxygenase gloE/GLOXY3) and 3S-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2 to yield pneumocandin B0), or 3S-hydroxyl-4S-methyl-L-proline (generated from L-leucine by the dioxygenase gloC/GLOXY4 to yield pneumocandin A0) are sequentially added to the growing chain (PubMed:25270390, PubMed:25879325, PubMed:25527531).  The last C domain of gloA/GLNRPS4 is proposed to be responsible for cyclization by condensation to form the peptide bond between L-ornithine and 3S-hydroxyl-4S-methyl-L-proline (for pneumocandin A0) or 3S-hydroxyl-L-proline (for pneumocandin B0).  Finally, the subsequent C-4 hydroxylation of 3S-hydroxyl-L-homotyrosine and L-ornithine dihydroxylation at C-4 and C-5 are performed by the cytochrome P450 monooxygenases gloP/GLP450-1 and gloO/GLP450-2, respectively (PubMed:25879325).
What are the official names of this protein?
Cytochrome P450 monooxygenase gloO, Ornithine 3,4-hydroxylase, Pneumocandin biosynthesis cluster protein O.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: FMO2_PANTR
Sequence: MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVITNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFSSSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGIERFKGQYFHSRQYKHPDGFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAHLDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFGESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS
What is the function of this protein?
Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation.
What are the official names of this protein?
Dimethylaniline monooxygenase [N-oxide-forming] 2, Dimethylaniline oxidase 2, FMO 1B1, Pulmonary flavin-containing monooxygenase 2, FMO 2.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: M1310_ARATH
Sequence: MLKRKLKPKRLQLPPQDVVFEGEAAMNEYTFYRNWVESWLQHIRSYYLLFIDGDPSLSKFFEIEICAHSWKRSTFDQQVFKFGLLWECVDIARSRTVYWQCALGTGHIQEDKVSEATSPFTDDSCTNSCLSRMTGQ
What are the official names of this protein?
Uncharacterized mitochondrial protein AtMg01310, ORF136b.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FPG_ECOHS
Sequence: MPELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDQPVLSVQRRAKYLLLELPEGWIIIHLGMSGSLRILPEELPPEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTKELEGHNVLTHLGPEPLSDDFNGEYLHQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARVIKAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATFYCRQCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: CCND_CAEEL
Sequence: MDFESSSAGPSTSYAEEPCTLSMLPQVSAVLSETSITESNVSCQLHPSRSAALNDNVRTLIYNRTDPHIQLDMRAFYNCMEYEEALQPNYHYFTGVQENITPFHREQAIDWIYDVAKEENCDGDVFLLAVSLIDRFMSVQNILKHDIQMIAGVALFIASKLKAPHPMTASKIAYYSDNSCPIDMILQWELLIVTTLQWETESPTAFSFFDFLASRIPQIHNMRGDFQTVVQKCQKMHKLATLFPSMQCAIGLYYVSNLPTQNKELAVKIKDLLANMFQLEVNLLDSYIPMVQRCMSTTPIYTSEDAEKTEPTPSAPASTQEPEAFQELKELKEEPLPTPPPEEPAFQKLVLLEPIPLSEQTPSTPLNDSGFSSDVSSPASSEKKRRRSTDWFEEDSTPPKIFKTL
What is the function of this protein?
In association with cdk-4, regulates the progression through the G1 phase of the cell cycle during postembryonic development (PubMed:10518501, PubMed:11684669, PubMed:25562820).  Regulates proliferation of the coelomocyte lineage and intestinal cells during late embryogenesis (PubMed:15708572, PubMed:11684669).  In complex with cdk-4, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP) (PubMed:16198291).
What are the official names of this protein?
G1/S-specific cyclin-D.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
Protein: CVMT1_OCIBA
Sequence: MALQNMDISLSTEQLLQAQAHVWNHMYAFANSMSLKCAIQLGIPDILHKHDHPMTLSQLLKAIPINKEKSQSFQRLMRALVNSNFFIEENSNNQEVCYWLTPASRLLLKGAPLTVAPLVQVVLDPTFTNPWHYMSEWFKHENHATQFEAANGCTFWEKLANKPSMGRFFDEAMSCDSRLVAHVLTKDYKHVIDGIRTLVDVGGGNGTMAKAIVEAVPTMKCTVLDLPHVVAGLESTDKLSYIGGDMFQSIPSADAILLKFIIHDWDDEEGLKILKRCKDAVGIGGKVIIIDVVVGVNHDVDEVLEDQLHFDMAMMSYFNAKERTMNEWEKLISAAGFTSYKLTPAFGVRSLIEAYP
What is the function of this protein?
Phenylpropene O-methyltransferase that catalyzes the methylation of the para-4-hydroxyl of chavicol to methylchavicol.  Can also convert eugenol to methyleugenol but with less affinity.
What are the official names of this protein?
Chavicol O-methyltransferase, (Iso)eugenol O-methyltransferase CVOMT1, S-adenosysl-L-methionine:(Iso)eugenol O-methyltransferase CVOMT1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: VE4_HPV5B
Sequence: MTDPNSKAPRLQGRQEDKQTQTPPPRPPPPPQPPLTPRPDSSPHQNSHNKPKPEEEGTDGGPPASQGDRKRSKGDQGPDTGPGLGPGRAPSPKPTPLGPPPGPGPRRSARLGPLQADRDPGEGPQVPAEGEVEGHPGGDQGHPPPTPPAPHNGHSGHGPKVQQPEGPEGREGHEEGAVGGDCGDEEGHPPPPPPPTNGHEGGLLSSVASLLVKWEGHFDQLVQSIQDDLEDYWKKLATPQ
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: MTNX_GEOTN
Sequence: MKKQLVLFCDFDGTITENDNIIAIMKQFAPPEWEALKDDILAERLSVQEGVGKMFSLLPSALKDEIVDFLLSTARLREGFREFVAFTKEKGIPLYIVSGGIDFFVYPMLDGLIDKERIFCNGSDFSSEMIRITWPHACDGKCQNGCGCCKPSLLRKLARPDGYHVVIGDSITDLAVAKQADYVLARDFLLKKCQELDLPHAPFTTFFDVVDHLQRLEVIA
What is the function of this protein?
Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase, HK-MTPenyl-1-P phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MtnX family.
Protein: K118B_XENLA
Sequence: MSYSRSMYSSSSVVGGSPYRSLSSAPRFAPGSSAASVHAGPGGSGARISVSRVSSVGSGFGGGFSGGFSGVSNVSLMGGAQNEKETMQDLNDRLASYLERVRSLETANKELEVQIRQHTEKKGPAKDWSPYYKAIEDLKKQVFDSTVDNSQLVLQIDNARLAADDFRVKYEAELAIRMSVETDIGGLRKLIDDTNISRLNLENEIESLKEELIFLKKNHQDDVNELQAQIARSAVTVEVDAPKSQDLGKIMAELRAQYDGLAQKNREDVEKWYQSKVEEHTMQVNIDTQELQTSKNSVTELRRTMQSLEIELESLRNQKASLEGTLHDTEARYAMELEMLGGTAMARESELVQVRSDCQRQQQEYQALLNTKMKLEAEIHTYRRLLEGDSFDLQDAVPTVTTQTVKKVITTTQRIVDGKVVAESNDTEVLKA
What is the function of this protein?
When phosphorylated, plays a role in filament reorganization.
What are the official names of this protein?
Keratin, type I cytoskeletal 18-B, Cytokeratin-18-B, CK-18-B, Keratin-18-B, K18-B.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: ISPH_VIBCH
Sequence: MKILLANPRGFCAGVDRAISIVERALELYQPPIYVRHEVVHNRFVVEGLKQRGARFVEELNEVPDDNIVIFSAHGVSQAVRQEAKERSLTVFDATCPLVTKVHMEVARASRKHMEVVLIGHAGHPEVEGTMGQYASDTGGMYLVEKPEDVVSLQAKVKDPSNLHYVSQTTLSVDETADVIDELRRVFPKIQGPRKDDICYATQNRQDAVRILAEQVDVMVVVGSKNSSNSTRLKELAEKLGTPGYLIDCPQDIDPEWFVDAQLIGVTAGASAPEELVNQILDRIKELGATSVEEVLGREENMFFEVPKELQIKQVD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RIMP_YERP3
Sequence: MGVGLSTLEQKLTEIISAPVEALGYELVGIEFIRGRQSTLRIYIDSDDGITVDACADVSHQVSAVLDVEDPITVAYNLEVSSPGLDRPMFTAEHYTRYLGEEVTLVLRMAMQNRRKWQGIIKAVDGEMITVTVDGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDB1_CHICK
Sequence: MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKTAVMELFRPKGESKDLLFILTAKYNACILEYKQNGDNIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRENKELKAFNIRLEELQVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDSHREMDNMLVLSFVGQTRVLMLNGEEVEETELTGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPNGKNISVASCNSNQVVVAVGRALYYLEIRPQELRQINCTEMEHEVACLDITPLGDTNGMSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLSLETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDASGGTTALRPSASTQALSSSVSTSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFHYSDGKLQSLAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTAEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLSHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLQIDDGSGMKREATVDDLIKIVEELTRIH
What is the function of this protein?
Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (By similarity).  Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity).  The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity).  Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (Probable).  The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity).  May play a role in the regulation of the circadian clock (By similarity).
What are the official names of this protein?
DNA damage-binding protein 1, DDB p127 subunit, Damage-specific DNA-binding protein 1, UV-damaged DNA-binding factor.
What is the protein family that this protein belongs to?
Belongs to the DDB1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DER_PROM2
Sequence: MILPTIAIIGRPNVGKSTLVNRLCQSNDAIVFDKPGVTRDRTYQNASWGGKEFQIVDTGGLVFDDDSEFLPEIRTQVFLALEEASLALLVVDGNQGVTDGDLSIAKWLRNSSCKTIVAVNKCESTTLGISLASEFWKLGLGEPNPVSAIHGSGTGDLLDLVIGELPENNIRDDEEKIMMSIIGRPNVGKSSLLNSICGEKRAIVSDISGTTTDSIDTLIKKGDNYWKIIDTAGIRRKKNVKYGTEFFGINRAFKSIDRSDVCVLVIDAVDGVTDQDQKLAGRIEEQGRACIIVVNKWDLVEKNSSTIYQVEKELRSKLYFLHWSKMIFISALTGQRVDNIFEHALNAVNQHRRRVTTSVVNEVLKESISWKSPPTKRSGKQGRLYYGTQVKNKPPTFTLFVNDPKLFGITYRRYIEKQIRLNLGFEGTPLILLWRGKQQRALNKEVERENIEVIQKD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ATG1_ASPNC
Sequence: MGLFHHSTLFLPLLRRSNEGPHGEMPIGHYTRLSEIGRGSFAVVYKGVHTRSRTYVAIKSVTMTKLSRKLKENLASEISILKQLHHPHIVALLDCHDTTSNIHLVMEFCALGDLSHFIKGRNTLQDSPYTRELIAKYPNPGEGAGLNEVIVRHFLKQLSSALRFLRDRDLIHRDIKPQNLLLCPAPSSYRSGAADVVPFKSSEDSFSPKTGLESLPMLKLADFGFARSLPATSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVVGRAPFRAVNHIELIKKIEQNKDQISFPSKNRVSEDIRELIRGLLKQHPMDRMNFDVYFAHKVLTEPIPGLVADDAPLGRSPADPTPRPGSGSRRSTPVQMKRENALSGGVRDEPATYPAAQRAMTQSPRPETPSTPMRRTGSAGTPHAAPNEPTPPASHPTRPSPVSLATAPGRQEHVDRPPTTTVVEQQRRRTASSGVPQVDKPVEKAKDEKEHAAQEVAFERDYVLVEKRAVEMNAFADELAYNPRMQGGQAGAVSRRSGAAPGTPPAGGSSPHASPSKAMQIISGRSRADSAHVRQNSYDRRYGQSPTSATSAISKALNMASGRLFGMSFSPPLTITKGGRSPPLAYNPFPAYPSAQTSLIVHADGGKPGANLDEDSKTVHDLEECATRSDVVYGFAEVKYKQLIPLAPSAATGYPGDPGSDAVDSADGGLTVDAIVTLSEEALVLYVKALSLLAKSMDIARVWWTRKSRGDTLSRADTGSTVAGNRINNVVQWVRNRFNEVLEKAEFVRLKLVEAQKRLPSDHPSHPSNLSVGSSLGSGTSADVVVSPDVTAEKLMYERALEMSRVAAINEITGEDLAGCEISYVTAIRMLEAILDDVEVSRPGQSGGADRADARRDNEDGGQNEPQAVILAKSANAWHSDIENPESPGVAPEEAGAAVESVHAPVQWTGQNAAVESGASLPCSGSHAAEIRTLTVRSMQDHAHFAPLLFSIFISSYSSSISCPSSCGHC
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
What are the official names of this protein?
Serine/threonine-protein kinase atg1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: NOX3_MOUSE
Sequence: MPVCWILNESGSFVVALLWLAVNAYLFIDTFFWYTEEEAFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNFISLVRGTSVCCRGPWRRQLDKNLNFHKLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGDAPNESYLNPVRTFDMGTTTELLMTVSGITGLGISLALVFIMTSSTEFIRRSSYELFWYTHHIFVFFFISLAIHGGGRIIRGQTPESLRLHNVTYCRDHYAEWQAAALCPVPQFSGKEPSAWKWALGPVVLYACERIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSVSPLEWHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFRVEGQAPSELCSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPELSKVYFYWICRDAGAFEWFADLLLSLETRMSEQGKAHLLSYHIYLTGWDENQAIHIALHWDESLDVITGLKQKAFYGRPNWNDEFKQIAYNHPSSSIGVFFCGSKAMSKTLQKMCRLYSSVDPRGVHFYYNKENF
What is the function of this protein?
NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox.  Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
What are the official names of this protein?
NADPH oxidase 3.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PNP_PHOPR
Sequence: MNPIVKTFQYGNHTVTLETGVMARQATAAVMASMDDTSVFVSVVGKKAAVEGQDFFPLTVNYQERTYAAGKIPGGFFKREGRPSEGETLTARLIDRPIRPLFPSAFKNEVQVIATVVSVNPEVNPDMITMIATSAALAISGLPFNGPIGAARVGFINDQFVLNPSNTELEESRLDLVVSGTKDAVLMVESEADRLSEETMLQAVVYGHDQQQVVINAINEFAAEVATPAWDWTAPVVNAELKARVADKAATRLSDAYQITEKMARYDEVGSIKNDVVASLLAEDETLDERELRGMLSSLEKHVVRGRIIAGHPRIDGREKDMVRALDVRTGVLPRTHGSSLFTRGETQALVTATLGTQRDAQIIDSIMGEKKDHFLLHYNFPPYCVGETGFVGSPKRREIGHGKLAKRGIAAVMPSVEEFPYTVRVVSEITESNGSSSMASVCGTSLALMDAGVPIKASVAGIAMGLVKEGDDFVVLSDILGDEDHLGDMDFKVAGTDDGITALQMDIKIEGITKEIMQIALNQAKGARKHILSVMDDAIGTHRDDISQFAPRIHTMKINSDKIKDVIGKGGAVIRALTEETGTTIEIEDDGTIKIAATEGAAAKEAIRRIEEITADVEVGRIYTGKVMRIVDFGAFVSVIGAKEGLVHISQIAQERVEKVSDHLQMGQEVQVKVLEIDRQGRIRLSMKEAVADQNPATVQDEQPQG
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.