PharMolix/UniProtQA huggingface dataset:
Protein: LIPA_BART1
Sequence: MVTVVDRVTNRRLRHPEKAHRPDTSVQKKPDWIRVKAPTSPVYKETHGIVRTHKLVTVCEEAGCPNIGECWSQRHASFMILGEICTRACAFCNVATGIPLAVDDDEPERVADAVARMELKHVVITSVDRDDLADGGAEHFAKVIYAIRRKAPKTTIEVLTPDFRHKDGALEVVVAAKPDVFNHNLETVPSKYLKVRPGARYFHSIRLLQRVKELDPTIFTKSGIMVGLGEERNEILQLMDDLRTADVDFMTIGQYLQPTRKHHPVIRFVPPEEFESFAKIGKVKGFLHMASNPLTRSSHHAGDDFAILQKARDEKFALQR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MESP2_MOUSE
Sequence: MAQSSPPQSLQGLVPLGLLPGLGLGSAIGLHVSGLVLRFVRFLPFYATRRPSQPAGPARSTRTTQATAPRRTRPAPAGGQRQSASEREKLRMRTLARALQELRRFLPPSVAPAGQSLTKIETLRLAIRYIGHLSALLGLSEDSLRRRRRRSADAAFSHRCPQCPDGGSPSQAQMLGPSLGSAMSSGVSWGCPPACPGPLISPENLGNRISNVDPRVTPPYCPQIQSPLHQSLERAADSSPWAPPQACPGMQMSPEPRNKTGHWTQSTEPAELTKVYQSLSVSPEPRLSLGSPLLLPRPSCQRLQPQPQPQPQWGCWGHDAEVLSTSEDQGSSPALQLPVASPTPSSGLQLSGCPELWQEDLEGPPLNIFY
What is the function of this protein?
Transcription factor with important role in somitogenesis.  Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways.  Regulates also the FGF signaling pathway.  Specifies the rostral half of the somites.  Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand.  Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling.  Acts as a strong suppressor of Notch activity.  Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.  May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes.  Controls also the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1.  Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers.
What are the official names of this protein?
Mesoderm posterior protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: UXAC_BRUSU
Sequence: MALNPDRLFSAEPGTREIARRLFASVEKLPIISPHGHTEPIWYARNEAFPDPASLFVKPDHYITRMLYSQGHSLESLGIASRDGRPSETDARKIWRLFATNWYLFRATPSRLWFEHAMETVFGITERLSQENADRIFDAIADQLTQPHMRPRALYDRFNIEAISTTDAATDPLIYHDEVIASGWHGRIIPAYRPDAAVDAGRPDFASEVEKLVGVAGTPLTWQGYLDAHRNRREYFKRRGATSSDHGHPTAQTADLSAGDASRLFDRVIKGNASTSDAEMFRAQMLTEMARMSIDDGLVMQIHPGSFRNHNPTVFERFGLDKGADIPRQTGFVDQLKPLLDAFGNDPRLTVILFTLDETAYSRELAPLAGHYPALKLGPAWWFFDSPEGILRYRKLTTETAGFYNTVGFNDDTRAYLSIPARHDMARRVDCAYLAGLVADHRLEEDEAYEVAHDLAYRLAKQTYKL
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: CPEY_SYNPY
Sequence: MKSATEQDSESDFYTAAAHLINCPGIETEQTLIEFLQYRESSCQSIKITKRKIVEVLARLGCIDAVPAIGKCLWSDDVYLVENSVWALQILQCQDQIFIDQMIDILRVDTTNQRISIQCLATLNISRSVDVIRPFQESSVPGIKGAAISGIAKLTRNFTRVPEISLNLLLPNQMDRHFAIQDLIDVDAIDQLNEIFAAPVSPVLKMRAVREMYGENSASVVDLNLLSSLDSLFSCDLSAINCVHEYDESPSSEFLVRDLYNTDFSRCYLALKYLSSRSASEIFPMLKESWVEEAHNDYGAHYCFICLFGSIFDWSAESKRWIFEVLLSSISNLRPQFQKSRAASILALAKLNPSMLCELIPEILSSRDSMPWDMRYSLIQSIDNYAELEIALKNKMIFQLSDNDIDQFVQARARMALAS
What is the function of this protein?
Involved in the biosynthesis of bilin.
What are the official names of this protein?
Bilin biosynthesis protein CpeY.
Protein: RS7_KINRD
Sequence: MPRKGPAPKRPLVVDPVYQSPLVTQLVNKILLDGKKSVAESIVYGALEGARDKTGGDPVVVLKRALDNVKPAIEVKSRRVGGSTYQVPIEVRPTRSTTLALRWLVGYARQRREKTMTERLLNEILDASNGLGAAVKRREDTHKMAESNRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Y6523_BACAN
Sequence: MFGAKKGNGHNKDFYDFNPKNLETIRNDLKNRHAELVIDALLKEEARQEIKRIIKRDYPVHFMDIDEDKVDDVIEYVVSELVGTGVIERLIKDRPDITDISYNGSHLIVESSDYKEIYKDNEHQITEQYITRLIQKFAHAVGKEFTPKNPIFDGVYGSIRINAVHSQNTNGNSTMSLRIVRPNLVLNEKNFETFAPQFIYDFFKVVMESRNNILISGETGTGKTEVLKLLFSFVRFDHKAIMIEDVPETHVKSLFPDKDVFSWLTGNGVTVTDEIVAALRNNPRWIMISELRGKETYEMIQAVLSGHHVVTSLHSVDAETSPKRLVNMSKIGYQVDEKSLEEDIMRYFNFGFHIKRVVVKTTDTTGKPIKRVVRYLAKIVEYSVEGCQMVFEQKYRNGKFTFSTGTLSEEFHDKLAEIDLSYELPKYTDEVAFKKGLIISR
What are the official names of this protein?
Uncharacterized protein pXO2-25/BXB0023/GBAA_pXO2_0023.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
Protein: RFBM_SALTY
Sequence: MSFLPVIMAGGTGSRLWPLSREYHPKQFLSVEGKLSMLQNTIKRLASLSTEEPVVICNDRHRFLVAEQLREIDKLANNIILEPVGRNTAPAIALAAFCALQNADNADPLLLVLAADHVIQDEIAFTKAVRHAEEYAANGKLVTFGIVPTHAETGYGYIRRGELIGNDAYAVAEFVEKPDIDTAGDYFKSGKYYWNSGMFLFRASSYLNELKYLSPEIYKACEKAVGHINPDLDFIRIDKEEFMSCPSDSIDYAVMEHTQHAVVIPMSAGWSDVGSWSSLWDISNKDHQRNVLKGDIFAHACNDNYIYSEDMFISAIGVSNLVIVQTTDALLVANKDTVQDVKKIVDYLKRNDRNEYKQHQEVFRPWGKYNVIDSGKNYLVRCITVKPGEKFVAQMHHHRAEHWIVLSGTARVTKGEQTYMVSENESTFIPPNTIHALENPGMTPLKLIEIQSGTYLGEDDIIRLEQRSGFSKEWTNERS
What is the function of this protein?
Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides.  This enzyme participates in synthesis of the LPS group B O antigen.
What are the official names of this protein?
Mannose-1-phosphate guanylyltransferase RfbM, GDP-mannose pyrophosphorylase, GMP, GMPP, GTP--mannose-1-phosphate guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 2 family.
Protein: PPK1_ERYLH
Sequence: MGSHPITQDNDLDPPTEPGERYFNRELSWLAFNDRVLAEACNDSYPLLERLRFLSISGSNLDEFVMIRVAGLVGQVQRGIDEVSDDGRSPREQLNAVVARLEELSERQQDIWRNLRVQLADAGVHVADEERVNAEAYGWLKQHFFESILPLLTPQALDPAHPFPFISNEGLGLLFTLRRGGEELVEMVLIPSALPRFIRVPGEDALYISIESLITRFAKELFPGFEIVGDGTFRVLRDSDIEIQEEAEDLVRTFRSAIQRRRRGQVIQLEIEEEFDPTAEALLREKLDTPGATFVKTDGMLGIAGLADIVDEDRPDLKFDSYSPRYPERVLEHDGDIFAAIREKDIVIHHPYESFNVVVDFIRRAAIDPDVVAIKQALYRAGTQSEVVDALVEAAENGKSVTAVVELKARFDEEQNLYWANKLERAGVQVIYGFVDWKTHAKVAMVVRREEEGFRTYCHFGTGNYHPITAKIYTDLSYFTADPRLGRDAAKLFNFVTGYVEPRELEMLAVSPIDLRETIYAAIDNEMVNAQAGKPAAIWMKMNQITDVDMIDRLYEASQAGVEIQLVVRGICNLRPGVPGMSDNIRVKSIIGRFLEHSRIYAFANGEPMPGTSSTVYISSADLMVRNLDRRVEQLVPIDNQTVHDQVLQQVLLANLLDNEQSWELQPDGSYFRVEVGEKSFNCHRYFMTNPSLSGRGGALEAGAVPKLALRKGAV
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: CYSD_YERPY
Sequence: MDEKRLTHLRQLEAESIHIIREVAAEFGNPVMLYSIGKDSSVMLHLARKAFFPGHLPFPLLHVDTGWKFREMYEFRDHTVKEFGCELLVHRNPEGVAMGINPFVHGSAKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINKGESIRVFPLSNWTELDIWQYIFLEKIEIVPLYLAKPRPVVERDGMLLMVDDDRIDLQPGEVIVQKKVRFRTLGCWPLTGAVESEAETLPAIIEEMLISTTSERQGRMIDRDQSGSMELKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: CCYL1_DANRE
Sequence: MGNTVSCCVSPSGSPKLPRQVERLEDYQNNTDISDDTGPYLQHISDREVPDDLALESNPSDHARASTIFLSKSQTDVRDRRKSNHINHVSPGLLSKKYSSCSTIFIDDSTVSQPNLKSTIKCVTLAIYYHIKNRDSDRSLDIFDEKMHPLSREQVPDDYSRTDPEHKLIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAELDICPSNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLSFPLEPLSNERAQKLEAISRLCEDKYKDLSRVAMRRSFSADNLVGIRRSNAVLS
What are the official names of this protein?
Cyclin-Y-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin Y subfamily.
Protein: DAPA_NOSS1
Sequence: MGDFGTVLTAMITPFKADGSVNYAVAAELAANLVDNGTDTLVVCGTTGESPTLSWDEEYNLFVEVLQTVAGKAKVIAGCGSNSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQHFQAIAQACPELPLLLYNVPGRTGQNLSPETVVRLAEIDNIVGVKEASGNLDQAGEIRRLTPKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLLPLFKTLFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLDLI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_SHEB5
Sequence: MAAKEVVFGNDARVRMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPLITKDGVSVAKEIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVVEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKALSQPCADSKAIAQVATISANSDESIGEIIATAMEKVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELDHPFVLLVDKKISNIRELLPILEGLAKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTVIAEEIGLELEKATLEDLGTAKRVVITKDNTTIIDGNGEQTQIAARVSQIKQQVEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALVRVASKIAEVEVLNEDQKHGVVIALRAMEAPLRQIATNAGEEASVVANTVKNGSGNFGYNAGNDTYGDMLEMGILDPTKVTRCALQFAASIAGLMITTEAMVAEIPQNASQDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLYG_EMENI
Sequence: MPVLSKLLPTLTLTLPLLAGPCLAAANPKLSKRFTFPIPSSTGSVTFSEPYEIAAGEIYDGELQTFGRGVECTGQDEGGESDTVFIVQEGGTLKNAIIGADQIEGVYCLGACTIENVWWEKVCEDALSLKEGSGPYVVTGGGAQGAEDKVIQHNSEGEVIVDGFTVYDFGKLYRSCGTCGDIQRSATITNVVAVSGSTIAGANGNFGDVVTIDSSNCATDVSAICTTYEADADGGEPEEVSTDVTEACVFEELPACE
What is the function of this protein?
Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.  Favors pectate, the anion, over pectin, the methyl ester (By similarity).
What are the official names of this protein?
Probable pectate lyase G.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DDL_NITMU
Sequence: MAGSHDFGKVAVLLGGRSAEREISLESGKAVLDALRSSGVDAHPFDPSEQHMDALLQQGYTRAHIALHGRYGEDGTVQGALELLGIPYTGSGVLASALAMDKWRTKLLWQSAGINTPRHILLDEQSDFDAVAKELGLPLIVKPSREGSTIGLSKVREAGEVAAAWHLAARHDAMVLAEQFIEGTELTASILGDVALPLVRIQVEGDLYDYQAKYLSDKTQYFCPSGVSEEQECLIRKQALQAHRLLGCEGWGRVDLILDKSGTPYFLEANTSPGMTTHSLVPMAAKAAGISFEELVLKILGLAHVG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCER1_RAT
Sequence: MTQTVNEREDPLNLGGGGWASSIPLRTWPSYHRRQRGAPMSKRRYRDGPKTEYEAPRKQPKQQHIPGPWFQPPRGPYWALYSNWGRCGGPWRPPLVAFQSPLCPAQMIRAYGLHPLCVCCCSCWNGPWNPGWERPPGRKKRWGRRGRGLRRHPRRSFPRNPPIDLSKMLRPVNLYGWRAPGMRAPRNTTQFIMNQVYEDMRQQEKLERQQAALRAHQAQAGGISPGDSTTNDAPQSGAEEDSQLPEDLYGFMQDPSLTFSPAPGQQNQSPTPGLVEEEEKNVDDDECDEEVCDEKEESEEEEVDGESEDEDVDEEEVEEAGNGEEREEDQEEEDVSEEAGLEEGEQREEDKFLPLGMPLSILVGDEEERENFMNYDYLSQEQIIPNVPEADLFMVPDISH
What are the official names of this protein?
Coiled-coil domain-containing glutamate-rich protein 1.
Protein: ERAL1_DANRE
Sequence: MTLRSCETFLRRSLRFSTALNLTAFPEHEQLYLRVSSGCSVFRPQTVRKCLFHWTPACTVSQGVFLDRLQKGAAVTDESLCNQPVSVSPDRAQQFSLLMKDPDQPENAKSLKVAIVGSPNAGKSTLTNQLLGRKLFAVSSKVHTTRSRAVGVLTENDTQIVLLDTPGLTTQIKAKRHQLENSLLVDPFKSLKEADLVVVLVDVSDKWTRSKLSYEVLKCLALNPDVPAVLVLNKVDLLKNKALLLDITAQLTEGMVNGKKIRIHGASKPVRKAAAGANSRLKEKKAAGSLEDEADHEDKLKALKSHGGWPHFKDVFMLSSIDHEDVETLKRYLFVAAKPCQWQYHSEVLTDQSPEDVCFNTIREKLLQNLPKEVPYTMTQEIEVWKESEDGVLDISIKLYVQKETHMKMVIGPGGQLITRINQEAGNDLMKIFLCNVRLKISVKLRK
What is the function of this protein?
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly.  Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region.  May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).
What are the official names of this protein?
GTPase Era, mitochondrial, ERA-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.
Protein: UBE2S_DANRE
Sequence: MNSNVENLPPQVLRLVYKEVSALAADPPEGIKIYPSEEDITELHTSIEGPEGTPYAGGVFRMRLVLGKDFPAVPPRGYFLTKIFHPNVGHKGEICVNVLKRDWKAELGLRHVLLTIKCLLIHPNPESALNEEAGKLLLEDYKEYASRAHLLTEIHAMGGTSGAPQEPADGPQPKKHAGDPNKRVVGAGLPTMGTGTNNSNISNTNIVAKKKTDKKRALRRL
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis.  Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 S, E2 ubiquitin-conjugating enzyme S, Ubiquitin carrier protein S, Ubiquitin-protein ligase S.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: GA7_GIBF5
Sequence: MSNFVTLIEPLELTGSRVLRIAVAFAALCGATGLLAFSWWIYKQSSSKPTLPYPVVGDTHAQSLEKNLIKGMQQYRDSPFFLAGSRPPLLILPMSVFHEIHNMPNEYISIIVEHEDKFQGKYTHITTIRPEIPATIRQDLTRNMPNIILELQDELTYASDQWPRTSKWSSVSLYDMMLRTVALLSGRAFVGLPLCRDEGWLQASIGYTVQCVSIRDQLFTWSPVLRPIIGPFLPSVRSVRRHLRFAAEIMAPLISQALQDEKQHRADTLLADQTEGRGTFISWLLRHLPEELRTPEQVGLDQMLVSFAAIHTTTMALTKVVWELVKRPEYIEPLRTEMQDVFGPDAVSPDICINKEALSRLHKLDSFIREVQRWCPSTFVTPSRRVMKSMTLSNGIKLQRGTSIAFPAHAIHMSEETPTFSPDFSSDFENPSPRIFDGFRYLNLRSIKGQGSQHQAATTGPDYLIFNHGKHACPGRFFAISEIKMILIELLAKYDFRLEDGKPGPELMRVGTETRLDTKAGLEMRRR
What is the function of this protein?
Gibberellin 13-hydroxylase; part of the gene cluster that mediates the biosynthesis of gibberellins (GAs), diterpenoids that may provide a selective advantage during infection of the preferred host plant, rice (PubMed:23825955, PubMed:9917370, PubMed:10347043, PubMed:12750377, PubMed:15925394).  Gibberellins (GAs) are diterpenoids and are synthesized via the mevalonate pathway (PubMed:12750377).  Biosynthesis of the major metabolite GA3 (gibberellic acid) from geranylgeranyl diphosphate (GGPP) requires 13 steps (PubMed:12750377).  The GGPP produced by the geranylgeranyl diphosphate synthase GGS2 is converted to ent-kaurene via ent-copalyldiphosphate in a two-step cyclization reaction performed by the bifunctional ent-copalyl diphosphate synthase/ent-kaurene synthase enzyme (CPS/KS) (PubMed:9745028, PubMed:10803977, PubMed:12750377).  Ent-Kaurene is metabolized to GAs by a series of oxidation reactions catalyzed by cytochrome P450 monooxygenases (PubMed:9917370, PubMed:12750377).  Cytochrome P450 monooxygenase P450-4 is an ent-kaurene oxidase that catalyzes the three oxidation steps between ent-kaurene and ent-kaurenoic acid (PubMed:11472927).  The highly multifunctional cytochrome P450 monooxygenase P450-1 then catalyzes four steps involving oxidation at two carbon atoms, in the main pathway from ent-kaurenoic acid to GA14 via GA12-aldehyde as well as producing kaurenolides and fujenoic acids as by-products (PubMed:11320210).  The cytochrome P450 monooxygenase P450-2 then converts GA14 to GA4 by removal of C-20 (PubMed:11943776).  GA4 is further converted to GA7 by the GA4 desaturase DES via 1,2-desaturation before cytochrome P450 monooxygenase P450-3, a 13-hydroxylase, hydroxylates GA7 to GA3, the final product of the GA-biosynthetic pathway (PubMed:12750377).
What are the official names of this protein?
Cytochrome P450 monooygenase 3, P450-3, Gibberellin 13-hydroxylase P450-3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TRMB_BDEBA
Sequence: MALNGEYAHVAFDELRAPLNKGKWRSDVFKADAAMPLDVEVGTGNGTYFAHHAKTHSDRLLVGLELKYKPLIQSIRRAVNAGCKNAAITRFHAFNIDHLFAEGEIDNVYIHFPDPWTSPKKPKNRFVCKENLELLFRLQKPGSFINFKTDSLVYFLWAMDEIRQSPYKIIFETQDLHNSDMKDQNFETAFEKIFLREGIKINFVRLQKI
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RGI4_ARATH
Sequence: MPRNPRFCFFLFLLFHSSLFFSIPCFSIDEQGLALLSWKSQLNISGDALSSWKASESNPCQWVGIKCNERGQVSEIQLQVMDFQGPLPATNLRQIKSLTLLSLTSVNLTGSIPKELGDLSELEVLDLADNSLSGEIPVDIFKLKKLKILSLNTNNLEGVIPSELGNLVNLIELTLFDNKLAGEIPRTIGELKNLEIFRAGGNKNLRGELPWEIGNCESLVTLGLAETSLSGRLPASIGNLKKVQTIALYTSLLSGPIPDEIGNCTELQNLYLYQNSISGSIPVSMGRLKKLQSLLLWQNNLVGKIPTELGTCPELFLVDLSENLLTGNIPRSFGNLPNLQELQLSVNQLSGTIPEELANCTKLTHLEIDNNQISGEIPPLIGKLTSLTMFFAWQNQLTGIIPESLSQCQELQAIDLSYNNLSGSIPNGIFEIRNLTKLLLLSNYLSGFIPPDIGNCTNLYRLRLNGNRLAGNIPAEIGNLKNLNFIDISENRLIGNIPPEISGCTSLEFVDLHSNGLTGGLPGTLPKSLQFIDLSDNSLTGSLPTGIGSLTELTKLNLAKNRFSGEIPREISSCRSLQLLNLGDNGFTGEIPNELGRIPSLAISLNLSCNHFTGEIPSRFSSLTNLGTLDVSHNKLAGNLNVLADLQNLVSLNISFNEFSGELPNTLFFRKLPLSVLESNKGLFISTRPENGIQTRHRSAVKVTMSILVAASVVLVLMAVYTLVKAQRITGKQEELDSWEVTLYQKLDFSIDDIVKNLTSANVIGTGSSGVVYRVTIPSGETLAVKKMWSKEENRAFNSEINTLGSIRHRNIIRLLGWCSNRNLKLLFYDYLPNGSLSSLLHGAGKGSGGADWEARYDVVLGVAHALAYLHHDCLPPILHGDVKAMNVLLGSRFESYLADFGLAKIVSGEGVTDGDSSKLSNRPPLAGSYGYMAPEHASMQHITEKSDVYSYGVVLLEVLTGKHPLDPDLPGGAHLVQWVRDHLAGKKDPREILDPRLRGRADPIMHEMLQTLAVSFLCVSNKASDRPMMKDIVAMLKEIRQFDMDRSESDMIKGGKCEKWQPQPLPPEKIVSTPRGSSNCSFAYSDESV
What is the function of this protein?
Receptor with a serine/threonine-protein kinase activity (By similarity).  Together with SKM1, LRR-rich receptor-like kinase (LRR-RLK) required for male fertility by the perception of CLE43 and CLE45 peptides and the transduction of their promoting action in pollen tubes, especially under relatively high temperature (at 30 degrees Celsius), thus conferring tolerance against high temperature probably through the maintenance of mitochondrial activity (PubMed:23910659).  Seems to not be involved in the perception of CLE45 peptide in roots (PubMed:27354416).  Together with RGI1, RGI2, RGI3, RGI4 and RGI5, acts as receptor of RGF1, a peptide hormone that maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT) (PubMed:27229312, PubMed:27229311).  Links RGF1 signal with its downstream components (PubMed:27229311).
What are the official names of this protein?
Leucine-rich repeat receptor-like serine/threonine-protein kinase RGI4, Protein RECEPTOR OF RGF1 2, Protein RGF1 INSENSITIVE 4, Protein STERILITY-REGULATING KINASE MEMBER 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SCYL2_MOUSE
Sequence: MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENVILNKSGAWKIMGFDFCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNQGRPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYIKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFSSFIAVIKEMLSRLESEHRTKLEQLHVMQEQQRSLDIGNQMSTSEETKVAHSGSQQIDKVFNNIGADLLSGSESENREDGMQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPIAPIKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTPVPSTGLGMMFSTPIDNTKRNLTNGLNANMGFQTSGFSMPVNPNQNFFSGTGTAGVTTMSLGAPPTMSNFSPLTIPPASVKQPQQRPTDMSALNNLFGPQKPKVSMNQLSQQKPNQWLNQFAPPQGSPVMGSAAMGTQGNVMGQAAFGMQGNPFFNPQNFAQPPPTTMTSSSSASNDLKDLFG
What is the function of this protein?
Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system.  A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (By similarity).  By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (PubMed:26203146).
What are the official names of this protein?
SCY1-like protein 2, Coated vesicle-associated kinase of 104 kDa.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Note=Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes.
Protein: PIMT_SCHPO
Sequence: MFWSFNLSSNAALVQHLVESKFLTNQRAIKAMNATSRSFYCPLSPYMDSPQSIGYGVTISAPHMHATALQELEPVLQPGCSALDIGSGSGYLVAAMARMVAPNGTVKGIEHIPQLVETSKKNLLKDINHDEVLMEMYKEKRLQINVGDGRMGTSEDEKFDAIHVGASASELPQKLVDQLKSPGKILIPIGTYSQNIYLIEKNEQGKISKRTLFPVRYVPLTDSPDDSSDY
What is the function of this protein?
Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.
What are the official names of this protein?
Probable protein-L-isoaspartate O-methyltransferase, PIMT, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.