PharMolix/UniProtQA huggingface dataset:
Protein: A40_VACCW
Sequence: MNKHKTDYAGYACCVICGLIVGIIFTATLLKVVERKLVHTPSIDKTIKDAYIREDCPTDWISYNNKCIHLSTDRKTWEEGRNACKALNPNSDLIKIETPNELSFLRSIRRGYWVGESEILNQTTPYNFIAKNATKNGTKKRKYICSTTNTPKLHSCYTI
What are the official names of this protein?
Protein A40.
What is the protein family that this protein belongs to?
Belongs to the poxviridae A40 protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type II membrane protein. Note=Not detected in virion membranes.
Protein: ACSA_SHEPA
Sequence: MSTQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSFDDHNLFIKWFYDGTLNASANCLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHAEVCKFANALRSQGVRRGDVVTVYMPMVPEAAVAMLACARIGAIHSVVFGGFSPDSIASRVIDGNSKVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWGSLMETASEHCIPEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEVYWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNYPTPARLGEMVDRHKVNILYTAPTLIRALMAEGKEQFEGFDGSSLRIMGSVGEPINPEAWRWYNDVIGHEKCPIVDTWWQTETGGILISPLPGATDTKPGSATRPFFGVQPALVDNIGNIVEGANEGNLVILDSWPGQMRTVFGDHDRFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHELVAEAAVVGYPHDIKGQGIYAYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVTNLGDSSTLADPAVIDTLIETRLNRSE
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: SYI_METBF
Sequence: MIKEITAKYNAEQIEKKITQLWKDSDAYRKTREHRKTGKRLFFVDGPPYTTGHIHLGTAWNKIIKDSILRYYSMNNRNILERPGWDMHGLPIEVKVEGVLGFKSKKDIESFGVENFIEKCKEFAINQKQEMTEQFQRLGVWMQWEAPYMTLKDDYIEAAWWTLKQASEKNLLDVGKRSVNWCPRCETAIADSEVEYAERTDPSIYVKFKIKGEENTFIVIWTTTPWTIPANVAVAVHPGFEYSKFRAIRQDGSDEILIAATDLIENVLRQGRYVDYEVLETMLGEDLTKLEYESPVGDLVPVQNEIKHGIYLADYVTAENTGCVHIAPGHGMDDFNVGVKYNLPILCPVGPNGAYTEEAGEYAGKNVREANPIVIEDLRKRNRLLAEGTVTHRYGHCWRCKTPIIYLATEQWFLKVTDIKDKMLEAIDAVDWYPEWAGSARFRTWVEGARDWCISRQRYWGMPIPVWKCKKCGKLEVIGTKAELLEKSGAGSDVELHRPYVDKLTIPCECGGEKKRVEDVFDVWFDSAVASWATLKFPQTREQFDEWWPADFITEGHDQTRGWFYSQLGASMVGFGRAPYKSVLMHGFTLDAGGKKMSKSLGNVVSPIDVIDKYGADTLRAYVLSSSAPWDDLKFNQEEVENVHRSINILWNVFRFPLPYMALDNFDPLKVSLDSVKDALREEDRWILSRIQSVVKAVDEAMSGYFLHKAVREILEFTLEDLSRWYIQLIRPRTWTEADDPDKLAAYRVLYEVYVTLTKLISPFMPYLAEEMYQNLIRNVDPNALESVHMCDWPKVNEAYLDPELEAAMSTARSIVEAASNARQKAGRKLRWPVSRIVVSPESEDAAKAVERLRSVLMDQTNSKAIVLTPVGESWDELGLEVIPDPSKIGPVFKKDAGKVIPALQKVDGFALKKAFAEAGEFELSLADRTTVTVTPGMANFKETLPEGTASAESDAGLVYVDANLTPELEAEGYAREVIRRLQDMRKELDLVVDENIRVSVRIEDERVLRLVETLKDLIAEEVRAEILNLGSDIDVSGALVKDWDVEGIAMKMGISKK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROL_SALCH
Sequence: MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRARETAALEAVSAPSTVVATGGGIILTDYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLRPTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQVVSEIIAALPPSTQRLQGDVYT
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAH3_PIG
Sequence: MAKEWGYADHNGPDHWHELYPIAKGDNQSPIELHTKDIKHDPSLLPWTASYDPGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLTAAYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNSKYNSFATALKHPDGVAVVGIFLKIGREKGEFQLVLDALDKIKTKGKEAPFTNFNPSCLFPACRDYWTYHGSFTTPPCEECIVWLLLKEPITVSSDQMAKLRSLYSSAENEPPVPLVRNWRPPQPIKGRIVKASFK
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase 3, Carbonate dehydratase III, Carbonic anhydrase III, CA-III.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_SALPK
Sequence: MRILLSNDDGVHAPGIQTLAKALRKFADVQVVAPDRNRSGASNSLTLESSLRTFTFDNGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLNGYQHYDTAAAVTCALLRGLSREPLRTGRILNVNVPDLPLAQIKGIRVTRCGSRHPADKVIPQEDPRGNTLYWIGPPGDKYDAGLDTDFAAVDEGYVSVTPLHVDLTAHSAHDVVSDWLDSVGVGTQW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_LISW6
Sequence: MLFEQIAANKRKTVFIVIGFFIFVLMVGAAIGIIVWNNYLNGLILAAVIGAFYILIMVMTSSSVVMAMNRAKRITSKEQAPVLWDTVESMAMVASIPMPKVYIMNDLSLNAFSAGISPEKGAVAVTQGLLDNLERYELEGVIAHEVSHIRNYDIRLSTISIALVAVIAILSDLAMRMIFWGSVTGSRNNRKNDNNSGGGAQLIIYIVALVFVVLAPIIATAIQFALSRNREYLADASAIELTRNPDGLIQALQKVSGDTKKMKEVSASSESIYFSSPLKSKKDKPGIFDSHPPISSRIERLENM
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS8_CELJU
Sequence: MSMQDPLADMLTRIRNAQGVGKATVTMPSSKLKVSVAKVLSDEGYINGFSVSESPKQELTVELKYFEGKPVIAELDRVSRPGLRNYAGKSALPTVRGGLGIAIVSTSKGVMTDRAARAAGVGGEVLCTVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: YUZM_BACSU
Sequence: MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQDQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ
What are the official names of this protein?
Uncharacterized protein YuzM.
Protein: FTHS_RHIEC
Sequence: MPSIKSDIEIARAATKRPIFEIGAKLGIAAEQLVPYGHDKAKVSAEFIAAQAGKKDGKLILVTAINPTPAGEGKTTTTVGLGDGLNRIGKKAIVCIREASLGPCFGVKGGAAGGGYAQVVPMEDINLHFTGDFHAITSAHNLLAAIIDNHIYWGNEENIDIRRITWRRVMDMNDRALRSMISSLGGVANGFPRQGGFDITVASEVMAILCLATDLKDLERRLGDIIIGYRFDKTPVHARDLKADGAMAVLLKDAMQPNLVQTLESNPAFVHGGPFANIAHGCNSVTATKTALKLGEYVVTEAGFGADLGAEKFFDIKCRKAGLRPDAAVIVATVRALKMNGGVKKEDLGTEDVAALKKGCANLGRHVANVRRFGVPVVVAINHFVSDTDAEIAAVKEFVSRLGAEAILCQHWAKGSAGIEELAHKVVELAESGQAKFQPLYGDDISLFEKIEIIASKIYHAGEVTADKAVRDQLQSWEEQGYGKLPVCMAKTQYSFSTDPNLRGAPEGHIVSVREVRLSAGAGFVVAITGEIMTMPGLPKSPSAERIFLNDQGYIEGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: PALM_PIG
Sequence: MEVLAAETISQQERLQAIAEKRRRQAEVENRRRQLEDDRRQLQHLKSKALRERWLLEGTPSSASEGDEDMRKQMQEDEQKARLLEESIARLEKEIEELENADTLPAPVKETQVAPSPGPVVPAPCPAQEDRKAEVDLNAQQTPVGTPKEKRISNTPMRMVEGSTMMNAAMYSVEITVEKDKVTGETRVLSSATVLPREHPPQGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDELIHKADEVTLSEAGSAAAPETRGPSEEVVRTTPSRREITGVQAQPGEATSGPPGIQPGQEPPVTMIFMGYQNVEDEAETQKVLGLQDTITAELVVIEDAAEPKEPAPPNGSAAEPLATEGSREENQVGPEAPASDPQDLDMKKQRCKCCSIM
What is the function of this protein?
Involved in plasma membrane dynamics and cell process formation.  Necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity).
What are the official names of this protein?
Paralemmin-1, Paralemmin.
What is the protein family that this protein belongs to?
Belongs to the paralemmin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine. Basolateral cell membrane; Lipid-anchor. Apicolateral cell membrane; Lipid-anchor. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.
Protein: H2A8_ARATH
Sequence: MVCNTNILKDVSTKISAFENVRMIMVEGEMFQVARIHKQLKNRVSAHSSVGATDVVYMTSILEYLTTEVLQLAENTSKDLKVKRITPRHLQLAIRGDEELDTLIKGTIIGGSVIPHIH
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.8, H2A-4, HTA4.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NADA_SYNP6
Sequence: MFLAADRPTTDLPADLPAAIAALKQELNAVILAHYYQEAAIQDVADYIGDSLGLSRQAAAADADVIVFAGVHFMAETAKILNPQRQVLLPDLAAGCSLADSCPPEAFAAFKAAHPNHIVISYINCTAEIKALSDIICTSSNAVKIVQQIPVDQPIIFAPDRNLGRYVMQQTGRDLVLWDGSCIVHETFSEQRLLELQARHPDAEIIAHPECETPVLDQARFIGSTTALLNYSLNSPSREFIVVTEPGIIHQMQQAAPEKTFIPAPPQDTTCACNECPFMRLNTLEKLYLCMRDRRPEIQIPEETRLAALRPIERMLAMSA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_CUPMC
Sequence: MARTAPAASFESLESDLDQKFAYPASSKTYITGSRPDIRVPLRTILQTATRTEKGEMANPPIPVYDTSGPYSDPDVHIDLKAGLPPVRAKWIEERNDTEVLTGLSSEYGLARANDPATAHLRFAQLTNPRRAKAGANVSQMHYARKGIITPEMEYVALRESLNLQALYDKPEYKALLRQHPGNALGAALPLRPEDMTPEFVRREVAAGRAIIPANINHTELEPMAIGRNFRVKINGNLGNSAVTSSLAEEVEKMVWSIRWGADTIMDLSTGKHIHETREWILRNSPVPIGTVPIYQALDKTGGIAEDLTWEMFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTADRVTGIVSRGGSIMAKWCLAHHKENFLYTHFDEICEIMKAYDVSFSLGDGLRPGCIADSNDDAQFGELRTLGELTAKAWEHDVQVMIEGPGHVPLQRIQANMDEELKHCYEAPFYTLGPLVTDIAPGYDHITSGIGAANIGWMGTAMLCYVTPKEHLGLPDKEDVREGIITYKIAAHAADLAKGWPGAQLRDNALSKARFEFRWEDQFNLGLDPERARSFHDATLPAEGAKIAHFCSMCGPKFCSMKITQEVRDYAASLPEAERGMQEKSIEFVKTGSKIYS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: ISCS1_ARCFU
Sequence: MPYFDYASTKPVDERVVEAMLPYMTEHFGNPSSVHSYGFKAREVIEEARGKISELINGGGGDIVFTSGATESNNLALIGYAMRNARKGKHVLVSSIEHMSVINPAKYLQKQGFEVEFIPVDKYGTVDLEFIEEKIREDTILVSVQHANNEIGTIQPIKEISEIINGRAALHVDATASLGQIEVDVEKIGADMLTISSNDIYGPKGVGALWVRQGVRLQPIILGGGQEKGLRSGSENVPAIVGFGKAAEITAKEWGEEAGRLRRLRDRIIDNVLKIEESYLNGHPEKRLPNNVNVRFSYIEGESIVLSLDMAGIQASTGSACSSKTLQPSHVLMACGLKHEEAHGTLLLTLGRYNTDEDVDRLLEVLPGVIERLRSMSPLYRR
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS 1.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SINE3_ARATH
Sequence: MKEIQIPRKSFARSSELGAKRLKDPEMKNRKVTTEKRQIATFSDVSFESTKDPMDFSPISQISGAISDSEAESVIQGSSLDLMSTPEICLPADDSPVSTITSVEARIDTSSTDRIQSIVDLPASVQSLRGEINELKKLICSVDNSAEINWVDRVVTVKFRIVLLSFILWAILAAIVVFFSSGEERAYRGPLPT
What are the official names of this protein?
Protein SINE3.
What are the subcellular locations of this protein?
Nucleus membrane; Single-pass membrane protein.
Protein: RS4_AGRVS
Sequence: MSKRASSKYKIDRRMGENIWGRPKSPVNRREYGPGQHGQRRKGKLSDFGVQLRAKQKLKGYYGDLREKQFRATYDEANRRKGDTSENLIGLLESRLDAIVYRAKFVPTVFAARQFVNHGHVSVNGVKVNIGSYRCKAGDVIEVRQKSKQLAIVLEATQLAERDVPDYIEVDHNKMVATFVRVPTLSDVPYAVIMEPQLVVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: YBED_ESCF3
Sequence: MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYTPTVKPSSKGNYHSVSITINATHIEQVETLYEELGKIDIVRMVL
What are the official names of this protein?
UPF0250 protein YbeD.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: UREE_PSECP
Sequence: MIIDKVLGNLHDLPENDLAAYTGLHREKVVLPSAQLVKRIQRATTDHGNEIGIRLASGSGDLRDGDILHVADTNMIVVSVLPTDVLVIAPRTIHEMGVTAHSLGNRHLQAQFFDADSEYGAAVMVCAYDHTVEDYLTHAGVPYTRQERVLPVPFRHAEHSH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INVO_HUMAN
Sequence: MSQQHTLPVTLSPALSQELLKTVPPPVNTHQEQMKQPTPLPPPCQKVPVELPVEVPSKQEEKHMTAVKGLPEQECEQQQKEPQEQELQQQHWEQHEEYQKAENPEQQLKQEKTQRDQQLNKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLELPEQQEGHLKHLEQQEGQLKHPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPQQQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQLKYLEQQEGQLKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKHLEQQEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEEGQLKHLVQQEGQLKHLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQQVGQPKNLEQEEKQLELPEQQEGQVKHLEKQEAQLELPEQQVGQPKHLEQQEKHLEHPEQQDGQLKHLEQQEGQLKDLEQQKGQLEQPVFAPAPGQVQDIQPALPTKGEVLLPVEHQQQKQEVQWPPKHK
What is the function of this protein?
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
What are the official names of this protein?
Involucrin.
What is the protein family that this protein belongs to?
Belongs to the involucrin family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
Protein: ATP6_RHOPA
Sequence: MAADPIHQFQITKLFTLGHVGGQEIAFTNSSAYMFGTVALIAILMLVPGRQLVPGRLQSIAELSYEFVANMIRSTAGKEGLKFFPLVFSLFMFIAVSNLIGIVPYTFTVSSHLIVTVALALLVFFTVLIYGFSKNGLKFFKLFVPSGVPIYILPLVVFIEVISFFLKPVSHSVRLFANMLAGHIALKVFASFVAMLGALGVVGWFGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYLNDAIHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TF2B6_HALSA
Sequence: MTDARMRSREQERTDETESESTDGCPECGGLVVNDEEHGESVCADCGLVVEEDGIDRGPEWRAFDSKEKDEKSRVGAPTTNTMHDKGLSTNIDWRDKDAYGNSLSSNQRQKMQRLRKWNERFRTRDAKERNLKQALGEIDRMASALGLPDNVRETASVIYRRALEDDLLPGRSIEGVATSCVYAAARQAGVPRSLDEIADVSRVEKAEIARTYRYVVRELGLEVAPADPESYVPRFASDLGLSDEASHRARELLKTAKDKGVHSGKSPVGLAAAAVYAAALLTNEKTTQAKVSEVADISEVTIRNRYHELLEAEDTIPV
What is the function of this protein?
Stabilizes TBP binding to an archaeal box-A promoter.  Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
What are the official names of this protein?
Transcription initiation factor IIB 6, TFIIB 6.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
Protein: XANQ_ECOLI
Sequence: MSDINHAGSDLIFELEDRPPFHQALVGAITHLLAIFVPMVTPALIVGAALQLSAETTAYLVSMAMIASGIGTWLQVNRYGIVGSGLLSIQSVNFSFVTVMIALGSSMKSDGFHEELIMSSLLGVSFVGAFLVVGSSFILPYLRRVITPTVSGIVVLMIGLSLIKVGIIDFGGGFAAKSSGTFGNYEHLGVGLLVLIVVIGFNCCRSPLLRMGGIAIGLCVGYIASLCLGMVDFSSMRNLPLITIPHPFKYGFSFSFHQFLVVGTIYLLSVLEAVGDITATAMVSRRPIQGEEYQSRLKGGVLADGLVSVIASAVGSLPLTTFAQNNGVIQMTGVASRYVGRTIAVMLVILGLFPMIGGFFTTIPSAVLGGAMTLMFSMIAIAGIRIIITNGLKRRETLIVATSLGLGLGVSYDPEIFKILPASIYVLVENPICAGGLTAILLNIILPGGYRQENVLPGITSAEEMD
What is the function of this protein?
Specific, proton motive force-dependent high-affinity transporter for xanthine.
What are the official names of this protein?
Xanthine permease XanQ.
What is the protein family that this protein belongs to?
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRKA_PYRHO
Sequence: MYIVIMGAGRIGTLVARMLESEGHDVAIIEMNRERAREISEYISGLVIEGDATDQKVLENANIKNANAFAALTGKDDANILACILAKHLNPNIMTILRITDPGKKKIFEDVKELKTYFDIVVSPEDIAANYIFRTLVTPGFNRVLLPREGAEIIQFQIDEDCEVAGKPVKELNLPKDSLIIAVYDEKGNLTIPSGDTIIPKKGQVIIFAKNSALQEVKKIMEKKKKEQ
What is the function of this protein?
Part of a potassium transport system.
What are the official names of this protein?
Trk system potassium uptake protein TrkA homolog, K(+)-uptake protein TrkA homolog.
Protein: DEF_SYNY3
Sequence: MTATILVEKQKVDRPPLELHYLGDKVLRQPAKRIAKVDDSIRKLAKEMLQTMYSANGIGLAAPQVGINKQLLVVDCEQDKPDEPPLIMINPQITRTSEELCVVEEGCLSVPNVYMDVTRPRAIEVTYKDEHGRPQKRLFAELTARVIQHEMDHLNGVMFVDRVDNPLALAESLKKEGFSMQAVKPVA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: S115A_GORGO
Sequence: MTDTPVEESLFQIIHCFHQYAARQGDMETLSLQELQALLMDNMPRFMDSLGQKEPYYVTELFQATDKNRDNQICFDEFLYILGKLVKDYHLQYHRQLCARYCAQHSLY
What are the official names of this protein?
Protein S100-A15A, S100 calcium-binding protein A15A.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
Protein: RLUD_BUCAI
Sequence: MKKIQLNSIASSCSLSGQRLDLVLSKLFREYSRSYLKKLIIMNQVLVNESIVNQPDKKILGGETLTIHPFSKDLLVDIPENIFLDIVYEDSDILIINKPAGLVVHPGSGNKSGTILNALLYHYKNSKDLPRAGIVHRLDKDTSGLMVIAKNIFSYNHLLLLLKEKKIIREYEGIVHGKMIAGGTINKPIMRHYNRRTCMMVHHLGKPSVTHYKVLSRFKFHTHIAIRLETGRTHQIRVHMLHIKYPLVGDPCYSGFKIQSNYRKDKKTNKIYKFPRQALHANHLSLHHPIKKNVMSWTVPLPQDIQELLLKI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase D, 23S rRNA pseudouridine(1911/1915/1917) synthase, rRNA pseudouridylate synthase D, rRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: MED1L_CAEEL
Sequence: MVSTPSPKTKVYLLEQRKNQELNIEHIDEEMRLEQVRQAASKMEWTSFGQAVRRNLLEKRNTIDADGRIDVLNGIAYMKTKMPIEENNLMEEKIRVMAESLGCLHKQTSRGWSINRQEDLIMDFTVNDGEVTTVVLSFWEEPSFYSPEATRMLQLGMWTELRNRISDMLLTYDKLLSRDDRRNCMGAMRMLEMLFGHFSQDPSYTSIHRSNYGFYLPRNDLRAGRVYYLAEPHFRNIRSKDHIFQLQKDDHEVLPYFEFSFAKHDSPCTLPEFDTKGWAESIEANAVICMKLSRGFNLTETTRKKLGAISAKTPSVKHFTNSYRYVTGAVKIENNLQMITQFGDGQTQHFYNVDVNQLRNDGDSVITEIYLKHLQDFHEIIAILRNEAMHISLWESMISACYEKQGMKKHTVAAIKMDVFLTREQIVITFDTKFAPVKVVIQDSGVCEAKVNVVHAQTGLQIAEKIDETLSRKLNETWSIPNMLTYAVSGSDCNLAKIKVPLRSENPETVGPIPTYAAGRSF
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 1.2, Mediator complex subunit 1.2.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1463_KLEP3
Sequence: MEMTNAQRLILSNQYKMMTMLDPDNAERYRRLQTIIERGYGLQMRELDREFGQLTEETCRTVIDIMEMYHALHVSWTNLKDAAGIDERRVTFLGFDAATEARFLGYVRFMVNIEGRYSHFDAGTHGFNSQTPMWEKYQRMLSVWHACPRQYHLSSNEINQIINA
What are the official names of this protein?
UPF0304 protein KPK_1463.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: MNMC_SHEDO
Sequence: MPSCYEHSAQSPRPLSVLAEYFPKGYSVFYKANTETCPEANQYSKALVDFYTQELNQAEDTNLTLGQMGLGDGVSLLLLWQSLLQCRKNNPELSRLKVHLLIFEPHAISALELKQLWQALGLFDANSPVAPQAEQFIAGKMAQINGAQRFILEQGQLRIDVHFGDLHSNLTELMTPEHRVTHWHCLPHIAHTQTEFAETQASQLQFNQVQSNANQLNQAILWQMGRLSQDNASLYLDGENFKPSASDNNALTDCTLIKMATQAGFSRYSPNLFQASSDSCNAIPLGERRALRQQQENRQAHCPVPNSLGERRQAVNNSDSIAIIGGGIAGACLALSLAERGKAVTLYCKDDKLGDGATGNRQGAIYPLLTPENSHLSQFFQQAFLFSRRRLLALLHEVYPIGHQLCGVLQTGFDERSEARLEKIIQGQHWPEEIAYAVSPEQASALAGVSIDKPGFYYPNGGWICPFEFARACLEKAKSLANVEVKLNSTISCIKPLAANVDSKDASGCTSQASGTLWGLYHQGEIVGSHQQVVLASGASITAFEQTQALQMSGFRGQVSHVPSKGELAKLNTVICANGYLTPAFNSTHCVGASYVKDPEHLDFCSDEQAENGQKMQQSFPNLEWPQDIDVSDRNARVGVRMVTRDHFPMMGCAPDIEEIISRYQTLNASPQASQNNYAKQCQQYWQQTPAPVHHNLFVLGGLGSRGLSSAPLAAECLAAQLCGEIAPISATTLALLNPNRMWMRKLLKGKALC
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.