PharMolix/UniProtQA huggingface dataset:
Protein: RL18_WOLTR
Sequence: MRRLYNFLSNSEKRNLRNRKKLNSGVKRLRISIFKSNRHFYAQLINDEKGVTLTSVSTLDAKIKDVCKRGINTETIKQVSSLMIERLSNMKLEQKLVFDRGAYKYTGLVSQFAEALRSSGFKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: SWI3A_ARATH
Sequence: MEATDPSAEIELYTIPAQSSWFLWDDIHEIERREFAEFFTESSITRTPKVYKEYRDFIINKFREDTCRRLTFTSVRKFLVGDVNLLQKVFLFLEKWGLINFSSSLKKNDHLLSVDNAKIEQGTPAGIRVTATPNSLRPITAPPLVEERVETGIKVPPLTSYSDVFSDLKKPDHVLVCAHCGERCDSPFYQHNKGIVNICEKCFKNGNYGENNTADDFKLIGNSAAAVWTEEEILLLLESVLKHGDDWELISQSVSTKSRLDCISKLIELPFGEFLMGSASGRLNPSILTEDENTEQVQTDGQEHEETETREEKEDRVNEDEPPAKRKRVALISEGDSSLMKQVAAMASKVGPSVATAAAKAALAALCDEASCPKEIFDTDDYSNFTVDRANGEKDTDMEEQQEEKDGPQGLPVALRIRASVATALGAAAAQAKILADQEEREMEQLAATVIEQQLKKLQSKLKFLDDLESIMDEEEKVIEGVKETIIQERVSVLQCAFRSGITKRWDHTYVK
What is the function of this protein?
Component of a multiprotein complex equivalent of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes.  It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
What are the official names of this protein?
SWI/SNF complex subunit SWI3A, AtSWI3A, Transcription regulatory protein SWI3A.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPF_CHRSD
Sequence: MTLRIGHGFDVHRFGDGDHLMIGGVRIPYVQGFVAHSDGDVLLHAICDALLGACALGDIGRHFPDTDAAWAGADSRDLLRHVHTLVMAAGYAVANLDATVIAQAPRMAEHIPAMRACIAEDLDLDTTAVNVKATTSERLGFTGRKEGIAAEAVVLLMPTGTT
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: Y855_TREPA
Sequence: MRIHQRSAPCVPVLLFLFLPSAPLCARGSKDWTPPQLGEVIESTEQDLAEFDAGLFRADRILDRHDLYRKTMHQLFSTLLEEPKNHAKHLQLIETLEKLAGPESKEIHEFLNRLRNSSTYAVYAARFFHLMERARILMARQEYLKAALLYRSGYELYYDEYLADPSSPGKKEVRARVEHAHAHVSRAKPLLEAVAAARAQYQNTQKRTYAASAHEAARARDAYSAAPAAPAAPGARAPSAAYPHSLTVEAELRILQDFSKTTEESAALTSLVQALGALLKFSRDIEHTGVVFEQLSTRAQKNNETQEAFLAVARKITLGRSKLEFEGILGALQAPAFDAFVDLFEAGRAHVAALHDQARAQFTFAHPPHSGRNIPAPTDTALASAGAWAAVGAGPAGSLIPGAPLSAGVGSRGAWGALPAPVEPLLRQADDALGALARLWAACAPLGAQHGRFPRDYETFGAQIVALSAHADALRATKHAYDFYHALLAFQRAPTVPVSAALRRQDLSQNEAFARDLSELAHHQEFLRRALAETESLSPPADTASTPSPGGAGDTPVPSQADKGGAKQSAAPDTAQKAVAQKAGASEEADASSSPSEMAVRAARAQLHAIQSELLRRFTALKRNRYTAHMAFHQHSGVSALAEYAQQLTSAEEALRFDAKDERRVRALSFVSETGPQQVSKDMEALDRLLSFFSGEEEFLSERGYAYGLQSLRDLRTQFEQFSARVQTLFLAAEQRAIHERLARQEAEYRYRQAVEGLGQDDFGGARKNLVLSREKADLALSLRYDTGYATETDTRLSTLDSSINRRENELVVKDVRAYIAQAKDKYYKGEVLDAERLLIRAKNRWAVTNVTENGEITNWLSVISTAVALKIGRVIPDFAPLYPQMSQLLHHAEQLYLHAAYLNASQRQEMERLLATSRENIHKVLLVYPLNERAGQLSLRIDQLLDPRSFRQQFAKKLDTIRGTYKTESKKAYSLLLDLYAIDARFSGIEKLKQEVEIYLGVRLPPPNPQAIAQSSNFTLAARRIFERRDAALYQVAIQQLDEALKLNPDNDAAAQLKDRIQSLTGDGAVNVLSSEDEKEYQRALQELQKGNKLVASAVVEQLLQKDRNKKSAKIQQLKKRIDAQL
What are the official names of this protein?
Uncharacterized protein TP_0855.
Protein: PACE_ACIBT
Sequence: MLISKRRLIHAISYEGILLVIIAIALSFIFNMPMEVTGTLGVFMAVVSVFWNMIFNHYFEKVEHKYNWERTIPVRILHAIGFEGGLLIATVPMIAYMMQMTVIDAFILDIGLTLCILVYTFIFQWCYDHIEDKFFPNAKAASLH
What is the function of this protein?
Mediates the efflux of short-chain diamines when energized by an electrochemical gradient (PubMed:31416917).  Recognizes specifically the short-chain diamines cadaverine and putrescine as substrates, and promotes the active transport of these substrates in exchange for a cation (PubMed:31416917).  Protons are probably the primary source of energy for transport, however it was not possible to conclude with complete certainty that protons, rather than alternative cations such as Na(+) ions, are exchanged for substrates by AceI (PubMed:31416917).  In addition, is involved in resistance to the synthetic biocide chlorhexidine, a widely used antiseptic and disinfectant in both hospital and community settings (PubMed:24277845, PubMed:25670776).  Interacts directly with chlorhexidine and mediates its efflux via an energy-dependent mechanism (PubMed:24277845).
What are the official names of this protein?
Short-chain diamines transporter, Acinetobacter chlorhexidine efflux protein I.
What is the protein family that this protein belongs to?
Belongs to the proteobacterial antimicrobial compound efflux (PACE) (TC 2.A.117) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GE_GAHVM
Sequence: MCVFQILIIVTTIKVAGTANINHIDVPAGHSATTTIPRYPPVVDGTLYTETWTWIPNHCNETATGYVCLESAHCFTDLILGVSCMRYADEIVLRTDKFIVDAGSIKQIESLSLNGVPNIFLSTKASNKLEILNASLQNAGIYIRYSRNGTRTAKLDVVVVGVLGQARDRLPQMSSPMISSHADIKLSLKNFKALVYHVGDTINVSTAVILGPSPEIFTLEFRVLFLRYNPTCKFVTIYEPCIFHPKEPECITTAEQSVCHFASNIDILQIAAARSENCSTGYRRCIYDTAIDESVQARLTFIEPGIPSFKMKDVQVDDAGLYVVVALYNGRPSAWTYIYLSTVETYLNVYENYHKPGFGYKSFLQNSSIVDENEASDWSSSSIKRRNNGTIIYDILLTSLSIGAIIIVIVGGVCIAILIRRRRRRRTRGLFDEYPKYMTLPGNDLGGMNVPYDNTCSGNQVEYYQEKSAKMKRMGSGYTAWLKNDMPKIRKRLDLYH
What is the function of this protein?
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions.  Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions.  Implicated in basolateral spread in polarized cells.  In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system.  Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips (By similarity).
What are the official names of this protein?
Envelope glycoprotein E, gE.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein E family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass membrane protein. Host endosome membrane; Single-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein. The heterodimer gE/gI then redistributes to cell junctions to promote cell-cell spread later in the infection (By similarity).
Protein: RPOB_BURP1
Sequence: MQYSFTEKKRIRKSFAKRSIVHQVPFLLATQLESFSTFLQADVPTAQRKSEGLQAAFTSVFPIVSHNGFARLEFVSYALSSPAFNIKECQQRGLTYCSALRAKVRLVLLDKESPSKPVVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDVLYFRVDRRRKMPVTILLKAIGLTPEQILANFFVFDNFTLMDEGAQMEFVPERLRGEVARFDITDREGKVIVQKDKRINAKHIRDLEAAKTKYISVPEDYLLGRVLAKNVVDGDTGEVIANANDEITEGVLEKLREAKIKEIQTLYTNDLDQGPYISSTLRVDETVDKTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEDAYDLSKVGRMKFNRRVGRDEITGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIGDDGALVDELVSSREAGETMMVTPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTVAVDSGTTVQALRGGVVDYVDAGRIVIRVNDDEAVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGELALGQNMLIAFMPWNGYNFEDSILISERVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREGIQRDKRAQQIIDDELKRYRLDLNDQLRIVEGDAFQRLARMLVGKVANGGPKKLAKGTKIDQAYLEDLDHYHWFDIRLADDEAAVQLEAIKNSIEEKRHQFDLAFEEKRKKLTQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPVEDMPYMADGRPADVVLNPLGVPSRMNVGQVLEVHLGWAAKGLGWRIGEMLARQTKIEELRVFLTKIYNESGRAEDLESFSDDEILELAKNLREGVPFATPVFDGATEEEMSKMLDLAFPDDIAEQLDMNPSKNQVRLYDGRTGEPFERRVTVGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDIDLDRN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: 3S14_NAJHA
Sequence: MICYKQRSLQFPITTVCPGEKNCYKKQWSGHRGTIIERGCGCPSVKKGIEINCCTTDKCNR
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin 4, Toxin CM-12, Toxin V-NH-I2.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Z354C_RAT
Sequence: MAVDLLAARGTEPVTFRDVAVSFSQDEWLHLDPAQRTLYREVMLENYSNLASLGFQASIPPVIGKLQKGQDPCMEREAPEDTCLDFQIQSEIEASSPEQDVFIEGPSRGLLKNRSTKCAYWKISFGELVKYERLETAQEQEKKAHEPGAASPKEVTSEDGIPTDPELEKPLFMNKALVSQETDPIERVPGMYHTSEKDLPQDFDLMRNFQIYPGQKPYVCSECGKGFSQSLHLLEHKRIHTGEKPYKCSECGKSFSHRSSLLAHQRTHTGEKPYKCSECEKAFGSSSTLIKHLRVHTGEKPYRCRECGKAFSQCSTLTVHQRIHTGEKLYKCAECDKAFNCRAKLHRHQRIHTGEKPYKCAECGKGYSQFPSLAEHQRLHTGGQLCQCLQCGRTFTRVSTLIEHQRIHTGQKPYQCNECGKTFNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQYSFLTEHERIHTGEKLYKCMECGKAYSYRSNLCRHKKVHLKERLYKWKEYGTPFMYGSSLAPHQRCLKGEKPEDLNSSL
What is the function of this protein?
May function as a transcription repressor.  Binds to 5'-CCACA-3' core sequence.  Suppresses osteogenic effects of RUNX2.  May be involved in osteoblastic differentiation.  Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).
What are the official names of this protein?
Zinc finger protein 354C, Protein AJ18.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS17_OPITP
Sequence: MSSSPAQRHTRKTQIGFVSSRSGDKSIKVTVPYKSPHPLYHKIVNRQTVLHVHDEKNEAKLGDTVEVMETRPMSRLKRWRIVSIVQRAVTTDAVAISETDVAAQVPTKTTASNTPAPAEQPAPQA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RL41_CYPCA
Sequence: MRAKWRKKRMRRLKRKRRKMRQRSK
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L41.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL41 family.
Protein: RS12_BRUME
Sequence: MPTVNQLIRKPRTAPVKRNKVPALQANPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: VES_SHISS
Sequence: MEYFDMRKMSVNLWRNAAGETREICTFPPAKRDFYWRASIASIAANGEFSLFPGMERIVTLLEGGEMLLESADRFNHTLKPLQPFAFAADQVVKAKLTEGQMSMDFNIMTRLDVCKAKVRIAERTFTTFGSRGGVVFVINGAWQLGDKLLTTDQGACWFDGRHTLRLLQPQGKLLFSEINWLAGHSPDQVQ
What are the official names of this protein?
Protein Ves.
What is the protein family that this protein belongs to?
Belongs to the Ves family.
Protein: MSRA_PSEMY
Sequence: MVLRSQILAHKLALPTAEQALPGRAEPLPVAQQHHVNGNPIKPPFPAPMQQAVFGLGCFWGAERRFWQQPGVFSTAVGYAGGFTPNPTYEEVCSGLTGHTEVVLVVFDPQQTSFDALLKVFWEAHNPTQGMRQGNDQGTQYRSAIYCQDHAQLEAALASQARFQAELDKAGLGSITTEICEAPIFYYAETYHQQYLAKNPGGYCGLGGTGVCLPPEPAA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: COQ7_CAEEL
Sequence: MFRVITRGAHTAASRQALIEKIIRVDHAGELGADRIYAGQLAVLQGSSVGSVIKKMWDEEKEHLDTMERLAAKHNVPHTVFSPVFSVAAYALGVGSALLGKEGAMACTIAVEELIGQHYNDQLKELLADDPETHKELLKILTRLRDEELHHHDTGVEHDGMKAPAYSALKWIIQTGCKGAIAIAEKI
What is the function of this protein?
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis (By similarity).  Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity).  Involved in lifespan determination in a ubiquinone-independent manner (By similarity) (PubMed:9020081, PubMed:25961505).  Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (PubMed:25961505).  Plays a role in modulating polyribosome formation (PubMed:30198021).
What are the official names of this protein?
5-demethoxyubiquinone hydroxylase, mitochondrial, DMQ hydroxylase, Clock abnormal protein 1, Protein clk-1, Ubiquinone biosynthesis monooxygenase COQ7.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion. Nucleus.
Protein: NHAB_SALPB
Sequence: MEISWGRAMWRNFLGQSPDWYKLALLVFLIINPFIFLANPFIAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVIIGMTSAAHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLVCGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKIKLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATALTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLSSISDNVFVGTIYINEAKAAMENGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTLIGLLCVEFTLAPATEWMTQAGWLATLS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLPP3_RHIME
Sequence: MRNDDDQEEKKTELPLGKETEANLFKSRSIFIYGTITQELAQKVCSQLVALAAASDDDIRLFVNSPGGHVESGDSIHDMIKFVKPKVWTIGTGWVASAGALIYVAAPKEQRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNERLNRIFSEATGQPVDKIAKDTDRDYWLGAEEAKAYGLVSRIVTSIAEI
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 3, Endopeptidase Clp 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_BURA4
Sequence: MSYRELVVELAREHAEALSDALLELGALSVSVEDADADTPDEQPLFGEPGLVPDRTAWQHSRVIALLSPDHEPAVLLAAAVNDIGVTETPKFDVREVEEQDWVRLTQSQFEPIPIGERIWVVPSWHDAPDPDALILELDPGLAFGTGSHPTTRLCMEWLEQSVKPGQSVLDYGCGSGILAILARKCGANPVVGIDIDPQAVESARQNSERNHAEVTYGLPDACPAGEFDIVVANILSNPLKLMASMLASKVKPGGRIALSGVLARQADEVAAVYARYVDISVWREHEGWVCLAGTRRESH
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_PRIM3
Sequence: MTKKVAVLPGDGVGTEVTKGAVAVLKAIGERFDHQFEFTYGLIGGAAIDEAGTPLPESTIETCKQADAVLLGSVGGPKWDRNPSHLRPEKGLLAIRKELDLYANLRPVTFYDSLADASPLKKEYIEGVDFIIVRELTGGLYFGKPSERRTEGNKETVVDTLFYKRTEIERIIRQAFDTAVNRRKKVTSVDKANVLESSRVWREVAEEVAKDYPDVELEHMLVDSAAMQLIRNPKYFDVVVTENMFGDILSDEASMLTGSLGMLPSASLTADGPSLYEPVHGSAPDIAGQNKANPIAAILSAAMLLRHSFGLEKEAAVIEQAVESVLHAGHRTADLADGNHYLGTDKMVEAITAVIANDSAISSIMTAYS
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity).
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_PSEA8
Sequence: MATVKVTLVKSLNGRLANHKACVKGLGLRRINHTVEVQDTPENRGMINKAYYLLRVEG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: CH3L1_SHEEP
Sequence: YKLICYYTSWSQYREGDGSCFPDAIDPFLCTHVIYSFANISNNEIDTWEWNDVTLYDTLNTLKNRNPKLKTLLSVGGWNFGPERFSAIASKTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKRHLTTLVKEMKAEFIREAQAGTEQLLLSAAVSAGKIAIDRGYDIAQISRHLDFISLLTYDFHGAWRQTVGHHSPLFAGNEDASSRFSNADYAVSYMLRLGAPANKLVMGIPTFGRSFTLASSKTDVGAPVSGPGVPGRFTKEKGILAYYEICDFLHGATTHRFRDQQVPYATKGNQWVAYDDQESVKNKARYLKNRQLAGAMVWALDLDDFRGTFCGQNLTFPLTSAVKDVLAEV
What is the function of this protein?
Carbohydrate-binding lectin with a preference for chitin.  Has no chitinase activity.  May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment.  Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation.  Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs.  Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells.  Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance.  Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity).
What are the official names of this protein?
Chitinase-3-like protein 1, Secretory glycoprotein of 40 kDa, Signal-processing protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Protein: UBB_GORGO
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC
What is the function of this protein?
Exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
What are the official names of this protein?
Polyubiquitin-B.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: YCIB_COXBU
Sequence: MKFLFDYFPIICFFVAYKFWGIYIATAAAMVVSALQVAIYWIRFRRFEKFHVITLIFILLLGSFTLVFHNAIFIKWKPTIVYWIFAIVLFGSHFFGKHTLVHRMLKEKIELPAKTWSRLNLSWALFFLILGVLNLFVVYNFDTNTWVNFKLFGTLVLTLVFILGQAFYIARHAQNLKMNSR
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISCA_ECOL5
Sequence: MSITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTPEDIVFEDKGVKVVVDGKSLQFLDGTQLDFVKEGLNEGFKFTNPNVKDECGCGESFHV
What is the function of this protein?
Is able to transfer iron-sulfur clusters to apo-ferredoxin.  Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically.  Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
What are the official names of this protein?
Iron-binding protein IscA, Iron-sulfur cluster assembly protein.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: URE3_CUPTR
Sequence: MELTPREKDKLLIFTAALLAERRKARGLKLNYPEAVALITAAIMEGARDGRTVAELMHEGTTVLTREDVMDGIAEMIPEIQVEATFPDGTKLVTVHHPIV
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.