PharMolix/UniProtQA huggingface dataset:
Protein: GLYA_CORS1
Sequence: IVAGWSAYPRQLDFVRFREIADKVGAYLFVDMAHFAGLVATGLHPSPVPHAHVVTSTTHKTLAGPRGGIILSNDAEIAKKLNSAVFPGQQGGPLEHVIAGKAVAFKIAASAEFKERQQRTLAGSRILAQRLTQADVAAKGISVLTGGTDVHLVLVDLRHSELDGQQAEDLLAKVEITVNRNSVPFDPRPPMTTSGLRIGTPALATRGFSEEAFAEVAEIIAQTLIAGAEGNTGVLPELKARILELAAAHPLYPNLKKIGE
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_SALRD
Sequence: MADQNDVDYEHLEYVDYKDTEFLEQFINNQGKILPRRVTGVPARVQRQITKAIKRARHLALMPYVSESVR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: 1104L_ASFPP
Sequence: MLVIFLGILGLLANQVLGLPTQAEGHLRSTDNPPQEELGYWCTYMESCKFCWECEHGICKNKVNRSMPWIIENSYLTSCEVSRWYNQCTYDEGNGHYHVMDCSNPVPHNRPHRLGRKIYEKEDL
What is the function of this protein?
Causes the redistribution of lumenal ER protein to an enlarged ERGIC compartment.
What are the official names of this protein?
Protein MGF 110-4L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 110 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment.
Protein: RLMF_ECO81
Sequence: MSAQKPGLHPRNRHHSRYDLATLCQVNPELRQFLTLTPAGEQSVDFANPLAVKALNKALLAHFYAVANWDIPDGFLCPPVPGRADYIHHLADLLAEASGTIPANASILDIGVGANCIYPLIGVHEYGWRFTGSETSSQALSSAQAIISANPGLNRAIRLRRQKESGAIFNGIIHKNEQYDATLCNPPFHDSAAAARAGSERKRRNLGLNKDDALNFGGQQQELWCEGGEVAFIKKMIEESKGFAKQVMWFTSLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMNDEQRRRFVNRQR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLH27_FORAG
Sequence: MYLNACRALTLISVLSLLACNSEPEKKQATPSKEIAKAQTGSWGDQGDGTYINPILNADYPDSDIEQVGDTYYMITSKQHMSPGMPILESKDMVNWTNVGHVFNSLSWAPEYNWDRMNGYSFGTWAGDLAYHEGTWYCYQIDYQHGLMVATSKDIKGPWSKPIMMLPKSEVLDDPAVFWDEDTHKAYIIINTAGKQKEASNTIEGNENRIYEMSWDGTKILDEGKLVYTGMGAEAAKIYKIDGTWYIFLAQWTMGDMSTKPGVKNPKNDRKQIVLRSKESIYGPYEVKTVLEKGTVFNNRSASQGALMQAPDNSWWYMHQLIQNDDIPFQGRPQCLEPVTWVDGWPIIGVDEDNDGIGEPVKTYKKPIDGYPVTAPRTDDDFSSPKLGFQWEWNHNPRNTHWSLTERPGWLRLKASKVLPNEKGYGPNINEWTNNDGSDSDFWRANNTLSQRIMGITTGTAVAKFDVSGMKPHQLAGFVRYGGVFNLLGVEVDEHGKKHLFYMEPMGEKTVGPEITVNDLYIRTSNRSNQAIYEYSFDGKNFKRFGPTFTIAFGKWTGDRLGLFSWNDKEDAGYIDVDWFTYDYDGPKAANQ
What is the function of this protein?
Xylosidase involved in ulvan degradation (PubMed:31285597).  Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall.  It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable).  Beta-xylosidase converts Xyl-Rha3S, a product of alpha-L-rhamnosidase acting on Rha-Xyl-Rha3S oligosaccharides, further to Xyl and Rha3S (PubMed:31285597).
What are the official names of this protein?
Beta-xylosidase, Glycosyl hydrolase 43 family protein P27, P27_GH43, Polysaccharide utilization locus H protein P27, PUL H protein P27.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 43 family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: Y4FL_SINFN
Sequence: MTSDLDTRLDLLRNITSKVGAFALARFGNLSHIVIETKGEADYVSAADRDAESLARRLIHAQFPADAIVGEEQLGDAEVDHWLIDPIDGTANFLSGIPLWAVSIAFVRNKEPVLGAVALPALDTLLWASVDGPLHGTGSVSPLVGAQPIAFGIGRNRTWPLAHRLEVEAAFEARGYHIVCLGSCAAALAMVAAGRLAGYVEHGTHLWDCAAGHVLCRAAGAPSSILFEADGKVAIIAAPQHLRVTAKADARSLSEKHIFDPGSDRISHRMESSAD
What are the official names of this protein?
Uncharacterized protein y4fL.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HMC1C_METSH
Sequence: MIEKRNFALRDKEGNEIGVFSGKQPRQAALKAANRGFTDIRLRERGTKKVHIFQGERIQVPKPSNAPKWMPANIWKPNVKKLGVEKLEDI
What is the function of this protein?
Protects DNA against thermal denaturation and modulates transcription.
What are the official names of this protein?
Chromosomal protein MC1c.
Protein: PAND_MICAN
Sequence: MGTIRLMHAKLHRVRVSEANVDYVGSITIDRELIERVGILPLEEVDVVNLSNGKRFSTYVFPGHTGEICPNGGAALLCQPGDILIIYAYEQRPRQEVLEKGHFAKVLVADAENRCQQFFEQSLIPRGDGRGVEFSSQEC
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NO12_VICSA
Sequence: MASFLLSTLVFFLAALILVPQGLAQYHLNPVYEAPVNGPPVNKPPQKETPVQKPPQKEPPVHKSPRNEPPRHKPPHKKSHLHVTKRSYGKHATEEHSIHF
What is the function of this protein?
Involved in the infection process during the plant-rhizobium interaction.  May also have an additional function in the proliferation of the bacteria.
What are the official names of this protein?
Early nodulin-12, N-12.
What is the protein family that this protein belongs to?
Belongs to the plant proline-rich protein superfamily. ENOD12 family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: MAN7_ORYSJ
Sequence: MEDAHHHHWTMVERRGTQLWASGRPFIIHGFNTYWLMSFAADQATRLRVTAAIAEAGLNVCCTWAFSDGGYRALQTAPFHYDEDVFRALDFVVSEARRHNMRLILSLCNNWEDYGGKAQYVRWGKEAGLDLTSEDDFFSDPTIKSYYKAFVEAVVTRINTVTNETYKDDPTILAWELINEPRCPSDPSGDTLQAWMEEMASYVKSIDPVHLLEIGIEGFYGPSIPELLPVNPDEYSGHAGIDFIRNHQAPGIDLASIHVYSDIWLPQSIKENHLQFVDKWMQQHIDDAANLLGMPIVVGEFGVSVKDGKFGNEFREDFMKTIYRIFLSSWKEGVIGGGCLLWQLFPEGAEHMDDGYAVIFAKSPSTLSLLANHLRCLEC
What are the official names of this protein?
Mannan endo-1,4-beta-mannosidase 7, Beta-mannanase 7, Endo-beta-1,4-mannanase 7, OsMAN7.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
Protein: MLTF_COLP3
Sequence: MTKFTSLLLVIFTTVLLSACDKENDSSSLSRILARGYINVGTIFGPTNYYTTANGFAGFEYELAKQYADSLNVELRIVPTYSLDELFIKLNTGEVDLLASGLSITDKRLQRFRFAPSYETISQKLVFKQGNVRPRKVADLTGTLMVTSGSSYVENLEKLKQTNSELAWQESTEFDSEELLRKVLSGEIDYTIIDSNNLAINRRYYPEISIGFSINEPEPLAWMVSENSHDDILASLVEFFGTVHHDGTLLALDDKYYGHIEQFNYVETRTFIKAVAGTLPEYQPLFEKYAQELDWRLLAAISYQESHWNPTARSYTGVRGMMMLTLATAKQMGIKSRLDTEQSIQGGAKYFKRMIAMMPDRIPTPDRIWFALASYNIGFGHLNDARIITQRQGGDPDRWVEVKSRLPLLQQKKYYKNTKHGYARGEEPVQYVDNIRRYYDTLSWLDEKAKEQAIALQLAQEKSQALLLNDIVNDSVNESTSEENATESILKEEEVTAETAQ
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: THIE_THISH
Sequence: MTETGERLRGLYAVTPDIPTDIEDLRARAEAVLRGGARLLQYRDKSADLPRREQAARALRALCERHGALFIVNDDVALALRVGAHGVHLGQQDMPLAEARAMLGREAIIGITCHERLDLALSAQAAGADYVAFGAVYPSPTKPGAVRAPLPLFTEARETLSIPVCAIGGIEADNAAAVIAAGADMVAVVSGVFARPDPEAEARRLAAMFEV
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: SYQ_CLOPE
Sequence: MSNAEHSSNFIRNIIIDDLDSKKHDTIITRFPPEPNGYLHIGHAKSIVLNFELGKEFNGRTNLRFDDTNPTKEDTEYVESIKEDVHWLGYNWSELHFASNYFDEMYKRALLLIKKGKAYVCDLTPEEIKEYRGTLTEPGKESPYRNRSIEENLDLFERMRKGEFEDGSKVLRAKIDMSSPNINFRDPIIYRIAHASHHNTGDKWCIYPMYDFAHPLEDAIEGITHSICTLEFADHRPLYDWFVKECEMESVPRQIEFARLNITNTVMSKRKLKQLVDEGIVDGWDDPRMPTVAGLRRRGYTPKSIRNFCKAIGVAKADSTVDSQMLEHFIREDLQETAPRAMAVINPLKLVITNYPEGESEILEIENNPKDESAGKRAVTFSREVYIEREDFMENPPKKYFRLFPGNEVRLKGAYFVKCNEVIKDENGEVTEIHCTYDPETKSGTGFTGRKVKGTIHWVDANNCIPAEFRLYEPLILDDCEENEGKHFLEQINPNSLTICKGFIEPSAKDAKPQDKYQLFRHGYFNVDPNFTSDDNLVFNRIVSLKSSFKLK
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_CHLTB
Sequence: MGMTSDSIANLLTRIRNALMAEHLYIDIEHSKMLEAIVRILKQHGFVAHFLVKEENRKRLMRVFLRYGEDRRPVIHALKRVSKPSRRVYVSAAKIPYVFGNMGIAVLSTPQGVLEGSVARAKNVGGELLCLVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: UBIG_XANAC
Sequence: MNSNTHAKSSNFHQSELDKFAALANRWWDADGPQKPLHALNPVRLEYVSARLEPAGARVLDVGCGGGLLSESMARLGAQVTAIDLAPELVKVARLHSLESGVQVDYRVQSVEDLAAEQAGSFDAVTCMEMLEHVPDPTAIIRACASLLKPGGKLFLSTLNRTPAAFALAVVGAEYIARLLPKGTHHYKDFIKPAELAAWLRNAGLQLEDVSGMLYEPWRNRARLSSRTEVNYLAYAVKP
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: SCK_HOTTA
Sequence: CQNECCGISSLRERNYCANLVCINCFCQGRTYKICRCFFSIHAIR
What is the function of this protein?
Inhibits potassium channels.
What are the official names of this protein?
Putative potassium channel blocker.
What are the subcellular locations of this protein?
Secreted.
Protein: LEXA_RHIWR
Sequence: MLTRKQHELLCFINDRLLQTGVSPSFEEMKEALDLKSKSGVHRLISALEERNFIRRLPNRARALEVLRMPETATAKPTAAASGKAKAAAPAVPQAANENVLEIPLHGRIAAGLPIEALEGQSSLSVPAALLGPGEHYALEVAGDSMVEAGILDGDYALIRRAETARDGEIVVALIADAEATLKYFRREGAMIRLDPANRAYDPQRYKPDQVRIQGKLAGLLRRY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: PYRE_CLOAB
Sequence: MEQYKQEFIEFMVESNVLTFGDFITKSGRRTPFFINTGNYKTGNQLNKLAKFYAKAIYDNFGDDFDILFGPAYKGIPLSVSVAMALDNIYGINAAYCSNRKEVKDHGDKGILLGAKLEEGDRVIIVEDVTTAGTSVYETMPILKSQAEVDVKGIIISVDRMERGKGDKSALTELKEKFGFKTCSIVTMEEVVEYLYKKNINGKVIIDDKMKDRINEYYKEYGVK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: WDR93_MOUSE
Sequence: MSSFKGNQAQKRRLSVFPKGPLEIPSPTEADWPKDDEKDFVFKDLDQELDSLPQPYRMINKLVDHLFNRSWEIIEERDSLREVEKNWIVPAIYHPVAEIQLDKMPGGMAVSHDYLFIGGLKGFSIYNLHNCKRIYVLEKFKADVISIWATDLGNDVLIVPIDEMGIVRLFYLCKDSLYHIKAINEVDDSSKQSTCLKMEISQNGDFAAFLFQGAGDVWLEVYKLPKEIWLKEMEHPQSTLNQKKKAKQLQLSTPDSAVTESIETSSGPSVSSNSVQDLNISFKSDLKLSLPVFVMKIKPPKPIAGTTFKSPLEVFAKVEDYVGLGSGQNHFIKDVQWEQHMETFYASYKKHLEGEWEEEPLSMATFHFFYTNSLTTMSMDVKSSSGIACVLGIHWNGRHNLFFYSLNKTQKDKTEYENVWPCAAPIVMSQISSFSSYLALVCEDGVLILWDLAEGFLFGVVALPEGCFCQSIHFLRFFLVHEGQNVYPDYPVKFEVMCVVLCTDASLHLVTASGTQGPTSKVLVGRPVMHMEEAICAVAPVPALPGMVLIFSRSQSVTLMDVAKAEVLCAFSAPTCHPQALPWKPLFAVSPHHPYFLLHGAHPHGQTTSTEDPKKSTDSVFYFNFEDYLLLKDISKKCTISQMAVNFSQMLPVEKRCEQVFQKSIQMTKTQMKGREQWSRLRKYSIMLQKELLKR
What are the official names of this protein?
WD repeat-containing protein 93, Protein MA0035.
Protein: PURR_EDWI9
Sequence: MATIKDVAKRAGVSTTTVSHVINKTRFVADETKAAVWEAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAPYFAEVIESVENSCYGHGYTLILCNSHNNLEKQKAYLAMLAQKRVDGLLVMCSEYPENLLESLEDYRHIPMVVMDWGTRRSDFTDAIQDNAFEGGYLAGRYLIERGHRDIGAITGPVSRNTGGGRLRGFLKALQEASITPLESWLVEGDFEPESGYTAMQNILSQKQRPTAVFVGGDIMAMGAICAADEMGLRVPQDISVIGYDNVRNARYFTPALTTIHQPKERLGAMAFDMLLDRITSKREDAQTIEVHPKLVERRSVADGPFIDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: Y2698_MYCVP
Sequence: MTEQGMHQELREGAGTAGDEGGLEAAAMDGGADNGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPELIAQMVDLGLAAGSRITQLAVVMDVRSRGFTGDLDWVRTELATRNIVPRVLFLEASDDILVRRYEQNRRSHPLQGNQTLAEGIAAERTMLAPVRASADLVIDTSSLSVHALRDSIERAFAGETVAHTNVTVESFGYKYGLPMDADTVMDVRFLPNPHWVDRLRPNTGQHHEVRDYVLGQPGALEFLDSYHQLLDVVIDGYRREGKRYMTVAIGCTGGKHRSVAMAEALAERLQDSDLTVRVLHRDLGRE
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Mvan_2698.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: DXR_PELPB
Sequence: MRSLAILGSTGSIGLSTLDVVRQHPEKFKIAGLAEGHDVALLAEQIKEFLPAAVSVRDADSVKKLQTLLGSHKPEIFHGLEGAAAIASAEGVDMVVSAIVGAAGLLPTVSAIKAGKHIALANKETLVVAGKLVSDLVKKHNVHLLPVDSEHSAIFQSLAGHRAEDVERIILTASGGPFRNTSAEELKNVTLEQALKHPQWTMGAKITIDSATMMNKGLEVIEAHWLFSMPAEKIGVVVHPQSIIHSMVEYIDGCVIAQLGSPDMRAPIAYALSWPERSESGIHKLDLPKIGTLTFEEPDMERFPALRLAFEALKAGLTYPAVLNAANEIAVAAFLDRKIGFTDIAATVEKTMQAHEAYDPIELDEYLQADRWAREMAKKFIA
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: DNAA_THEFY
Sequence: MSEGQINLAMVWSRVLDNLDNNSLPPQHRAWLPQTRPLGLIEDTALLAAPNEFAKEILETRLRTVISQALSAELGREIRVAVTVDPSAVPPSAPTEEASSTSSPDSSHPAPDQGSASYSGPRDTARQQAWSQQPVLPDPQPTAPQFTPSGRPGPLPGEPFSRGPDLLSSGWNPSSADPGSPASPAPVAESDTGPRYQSWDTSAPHWDQPNRWETPRPWEGGPHPGAGNRPHDVGGDSGVPSAEQPPVTPPLGVTERGDGSTNPTSGGPDQLNPKYTFDTFVIGSSNRFAHAAAVAVAEAPAKAYNPLFVYGGSGLGKTHLLHAIGHYTQRLYEGARVRYVSSEEFTNEFINSIRDGKADGFRRRYRDIDVLLVDDIQFLENKEQTQEEFFHTFNTLHNSNKQIVISSDRPPKQLVTLEDRLRNRFEWGLITDVQPPELETRIAILRKKAAQEGLNAPPEVLEFIASKISTNIRELEGALIRVTAFASLNRQSVDLHLTSIVLRDLIPNDEVPEITAAEIMAQTASYFGLTPEDLCGTSRSRVLVTARQIAMYLCRELTDLSLPKIGQQFGRDHTTVMHADRKIRSLMAERRSIYNQVTELTNRIKQQAHHNHHHL
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRR18_HUMAN
Sequence: MPFPPMPPPPAPAPGAQAARQLPRRPCAAGDKKKRPPQRPEGLLSSSWPSATLKRPPARRGPGLDRTQPPAPPGVSPQALPSRARAPATCAPPRPAGSGHSPARTTYAATSAGTGTTAAGTSSGAGPCPDSAARFCLNLTPEAVLVIQKRHLEKQLLARPRRPFPSPSAEPRRLLAPCLPARAAGPRRGGPASDPDAPPTAGQGRRAPPPGAQLLHGGLQVPQLSPRPGALRPMLKVSLLNERHRYDDVEYEEEPEAVDEGLVRKCTEWLRGVESAAAARGRAGALDSRRHLSTL
What are the official names of this protein?
Proline-rich protein 18.
Protein: VATA_METKA
Sequence: MSNSVKGEIVKIAGPVVEAVGCEGAKMYEVFRVGDEGLIGEVINIESDRATIQVYEETTGLQPGEPVKGTGELLSVELGPGLLTQIFDGIQRPLPEIRKEVGDFVERGILVSALDRKKKWEFTPKVKEGEKVEEGDVLGTVPETEFIEHKIMVPPGVSGEVIEIAADGEYTVEDTIAVIEDEEGEEHEVTMMQEWPVRKPRPYKRKLDPEEPLITGQRVIDTFFPVAKGGTAAIPGPFGSGKTVTQQQLAKWADAQVVVYIGCGERGNEMTEVLEDFPELEDPRTGRPLMERTILVANTSNMPVAAREACIYTGITMAEYYRDMGYDVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLASRLAEFYERAGRVVCLGSDDRVGSVTVVGAVSPPGGDFSEPVTQNTLRIVKVFWALDSKLADRRHFPAINWLQSYSLYLDDVEKWWHEEIGGDWRELRDEAMEILQRESELEEIVQLVGPDALPESERLILEVARMIREDFLQQNAFHEVDTYCPPEKQYEMLKTILHFKERAEEAVDKGVPVDEILKLDVIDDIARMKVIPNEEAKEKIQEIRKKIDEQFEELIEEAS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: METAA_HALH5
Sequence: MPIKIPDNLPAKEILTKENIFVMAESRAYSQDIRPLKIVILNLMPIKQTTETQLLRLLGNTPLQVEVSFMYTDTHISKNTSYDHLQTFYQTIDEVKQKKFDGMIITGAPIETLPYDEVDYWNELKQIMEWSKTNVTSTLHICWGAQAGLFYHYGVEKVPLPEKQFGVYPHKINVPNVKLLRGFDDEFYVPHSRHTDINKAQIEAHPDLEILSESEQAGVYIVASKDGKQIFVTGHSEYDACTLQQEYERDRARGLNIQVPENYFPNDDATRKPLLRWRAHSYLLFSNWLNYYVYQETPYDLSR
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
Protein: LOLD_IDILO
Sequence: MTDALLRCKELSKSYQDGGDQVTVLKDIDFALQAGEMVAVVGASGSGKSTLLHLLGGLDKPSSGQLFYKDQEMTPWKADKLAQWRNQNLGFVYQFHHLLPEFSALENVAMPQMIAGKSPTEAKQQAEQLLVRVGLEHRLSHRPAQLSGGERQRVAIARAFVNKPQVVLADEPTGNLDGEAAESIYQLMLELNQEMGTAFIVVTHDLQLAEQLQRVEVLKNGILHKEQG
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MTG1_BOVIN
Sequence: MRLSPRSLCAAVRAAWRESFPLEGRDVARWFPGHMAKGLKKMQSSLRLVDCIIEVHDAQIPLSGRNPLFQETLGLKPHLLVLNKMDLADLKEQQKIIQHLEREGIKHVVFTNCVKDENVKQVIPTVTELVGSSYRYHRGEHVEYCIMVIGVPNVGKSSLINSLRRQHLRKGKATRVGGEPGITRAVMSRIQVCERPLMFLLDTPGVLAPRIPSVETGLKLALCGTVLDHLVGEETLADFLLYTLNRHQLSGYVQHYGLGEACDDIASVLKRVAVKLRKTQKVKVLTGTGNVNVIQPDYPAAARDFLRAFRSGLLGPVMLDRDLLQGRSAEES
What is the function of this protein?
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity).  Displays mitochondrial GTPase activity (By similarity).
What are the official names of this protein?
Mitochondrial ribosome-associated GTPase 1, Mitochondrial GTPase 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: REV_HV1Z3
Sequence: PPPNPEGTRQARKNRRRRWRRRQQQIRSISERILSTCLGRPAEPVHLQLPPLERLNLDCSKGTATGVGSTQIPGESCAVLGSGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm (By similarity).
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: KTHY_BRUO2
Sequence: MSGLFITFEGGEGAGKSTQIALLASHLRNHGFDPVITREPGGSPGAEAIRHVILSGNAETYGPAMEALLFAAARADHVDQLIRPTLAEGRIVLCDRFIDSSRAYQGVTGNLDATYMAAIERIAIDGAMPDLTLVLDICAERGLSRAGKRRGSDTADRFEKEDIAVHEARRQAFLEIARQEPARCKVIDADRSQEKIADEIRSVVDTILTEKGLL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.