PharMolix/UniProtQA huggingface dataset:
Protein: ILVC_SPHAL
Sequence: MQVYYDRDADQDLIKGKKVAVVGYGSQGHAHAQNMRDSGVKEVAIALRPGSPTAKKAEAAGFKVMSNKEAAAWADVIMIAAPDEHQAKIYAEDIGPNMKPGAALAFAHGLNIHFGLIEARPDIDVFMVAPKGPGHTVRSEYQKGGGVPCLIAVAQEAQGSAAAGNGYAKALALSYASAVGGGRSGIIETTFKEECETDLFGEQAVLCGGITHLIQAGFETLVEAGYAPEMAYFECLHETKLIVDLLYEGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQSGRFVKDFVLDNQAGQPELKASRKAAAAHPIEQTGEKLRAMMPWIAKNKLVDKAKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ISPG_THEVB
Sequence: MQTLPSPVQATPTETAIVRRKTRPVPIGSVVIGGGHPVAVQSMINEDTLDIEGSVAAIRRLHEIGCEIVRVTVPSLAHAKAMEEIRDRLYKTYKPVPLVADVHHNGMKIALEVAKYVDNVRINPGLYVFEKPKPNRTEYTQAEFDEIGAKIRETLEPLVISLRDQGKSMRIGVNHGSLAERMLFTYGDTPEGMVESALEFIRICESLNFYNLEISLKASRVPVMIAANRLMVKRMDELGMDYPLHLGVTEAGDGEYGRIKSTAGIATLLAEGIGDTIRVSLTEAPEKEIPVCYGILQALGLRRTMVEYVACPSCGRTLFNLEEVLHKVREATKHLTGLNIAVMGCIVNGPGEMADADYGYVGKQPGYISLYRGREEVKKVPEAEGVAALVELIKADGRWVDP
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate, using ferredoxin I (PetF) as the reducing agent.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: EFG_MESHJ
Sequence: MARKFELKDYRNIGIMAHIDAGKTTTTERILFHTGKIHKIGETHDGVSQMDWMEQEKERGITITSAATTAFWKGKRINIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATNYSVPRIVYVNKMDKAGANFEASIESVRTKLNGNAVAIQLNIGAEADFSGLIDLVEMKAYNYDGQKEEIEYEIPIPEDLFEKASQMRLALAEAVADYDEEIFNNLLEEKEILPEQLKAAIRAATITGNFFPVVCGSSFKNKGVKKMIDAVIDYLPSPVDVPPIKAFRDEEEITIEASDDQEFSALAFKIMNDPFVGSLTFFRVYSGVLKKGTYIINSTKGKKERVGRILAMHANSREEIDEVRTGDIGAFVGLKDTTTGDSLISEKAKTFVLERMNFPEPVISQSLEPFSKAEIEKLATALQKLANEDPTFKTWTDIETGQTIIAGMGELHLDIIVDRLKREFNVQARVGKPQVSYRETITKSAEVEGKYIKQSGGRGQYGHVWIKFEPNPEEGFDFIDKIVGGKIPKEYIKSIQKGLEEKMQAGILAGYPLINLRATLFDGSFHEVDSSEMAFKIAASKALSRARDAVGTVLLEPIMDVSVFAPSEYAGDVMGDLSRRRGLVREQETRSDGANVIRGHVPLAEMFGYSTQLRSMTSGRGTYQMQFNHYEIVPKNISDVIVKQRAIKEDD
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y044_MYCBO
Sequence: MPKKYGVKEKDQVVAHILNLLLTGKLRSGDRVDRNEIAHGLGVSRVPIQEALVQLEHDGIVSTRYHRGAFIERFDVATILEHHELDGLLNGIASARAAANPTPRILGQLDAVMRSLRNSKESRAFAECVWEYRRTVNDEYAGPRLHATIRASQNLIPRVFWMTYQNSRDDVLPFYEEENAAIHRREPEAARAACIGRSELMAQTMLAELFRRRVLVPPEGACPGPFGAPIPGFARSYQPSSPVP
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator Mb0044c.
Protein: DGT2B_UMBRA
Sequence: MEQVQVTALLDHIPKVHWAPLRGIPLKRRLQTSAIVTWLALLPICLIIYLYLFTIPLLWPILIMYTIWLFFDKAPENGGRRISLVRKLPLWKHFANYFPVTLIKEGDLDPKGNYIMSYHPHGIISMAAFANFATEATGFSEQYPGIVPSLLTLASNFRLPLYRDFMMSLGMCSVSRHSCEAILRSGPGRSIVIVTGGASESLSARPGTNDLTLKKRLGFIRLAIRNGASLVPIFSFGENDIYEQYDNKKGSLIWRYQKWFQKITGFTVPLAHARGIFNYNAGFIPFRHPIVTVVGKPIAVPLLAEGETEPSEEQMHQVQAQYIESLQAIYDKYKDIYAKDRIKDMTMIA
What is the function of this protein?
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.  Required for storage lipid synthesis.
What are the official names of this protein?
Diacylglycerol O-acyltransferase 2B, Diglyceride acyltransferase 2B, MrDGAT2B.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GCSH_TERTT
Sequence: MSEIRSELKYLSSHEWARVEEDGTVTIGITDHAQEALGDVVFVETPEVGSQVSAGEEAGVVESVKAASDIYSPVTGEVIAVNELLEEAPETVNESPYDEGWFFKVKPSDVSELDGAMDSEAYVKSVEDDS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: TBPL2_TAKRU
Sequence: MDESALERYFEDSIANDSGFILEEELGLHSPALSSTQDSTYLSGRAGPSRESGAELDLSFLPDDLSTQEELGHHDNTAQAEDRAVSQDSAVCLDYDSQNSATPAATFDQQNPSLLGGGVHNSPFYSMTPMTPMTPMTPVTERSGIIPQLQNIVSTVNLGCPLDLKFIALQARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFMDFKIQNMVASCDVCFPIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKERAEIYEAFENIYPILRGFRKQ
What is the function of this protein?
TATA box-binding transcription factor.  Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis (By similarity).
What are the official names of this protein?
TATA box-binding protein-like 2, TBP-like 2, TATA box-binding protein-related factor 3, TBP-related factor 3.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL20_CAMLR
Sequence: MARVKTGVVRRRRHKKVLKLARGFYSGRRKHFRKAKEQLERSLVYAYRDRRRKKRDFRRLWIVRINAACRLNDISYSKFINGLKKAGIELDRKILADLAMNDAAAFAKIADAAKKAL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: GATA_NITHX
Sequence: MTDLTSLTLAEARDGLANKSFTALELTDAHLEAIERARVLNAYVLETPAQARAMAREADVRIAKGEGGPLNGLPLGVKDLFATEGTRTTACSQILDDFKPPYESTVTSQLWRDGAVMLGKLNNDEFAMGSSNETSRFGPVVNPWRRQGSDAKLVPGGSSGGSASAVAAGLCLGATATDTGGSIRQPAAFTGTVGIKPTYGRCSRWGIVAFASSLDQAGPIARTVRDAAILMHSMAGHDPKDTTSVDRPVPDYEAAVGKSVKGMKIGIPKEYRLDGMPAEIEKLWTQGAGWLKSAGAELVEVSLPHTKYALPAYYIVAPAEASSNLARYDGVRYGARVEGRNIVEMYENTRAKGFGAEVRRRIMIGTYVLSAGYYDAYYLRAQKVRTLIKKDFEDCYAAGIDAILTPATPSAAFGIGEKAGADPIEMYLNDIFTVTANMAGLPGIAVPAGRDAQGLPLGLQLVGRPFDEETLLSLGEVIEQAAGRFTPERWW
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: RLMH_METNO
Sequence: MRLALVAVGRLKRGPERELVETYRERADALARGLGFSAVQVTELAESRARRAPDRCAEEGAAILDAVPPGSALVVMDEGGRPVTSLALAEQVGAWRDGGRPGLAIVIGGADGLCESVKRRADLLFAFGAATLPHGLVRVLVLEQLYRVMTILAGHPYHRGAP
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPD_CORGL
Sequence: MSERQLEKSIEHAVELAREARNIEVFTGAGMSADSGLETYRDDKTGLWSNVDPQAMASIDAWRKDPEPMWAWYRWRAGVAARAEPNAGHQAISYWEGSDTVEHVHITTQNIDNLHERAGSSDVTHLHGSLFEYRCSDCATPWEDDKNYPQEPIARLAPPQCEKCGGLIRPGVVWFGENLPVEEWDIAEQRIAEADLMIIVGTSGIVHPAAALPQLAQQRGVPIVEISPTRTELSRIADFTWMSTAAQALPALMRGLSA
What is the function of this protein?
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins.  Modulates the activities of several proteins which are inactive in their acylated form.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYP_RHOE4
Sequence: MALPAIPQPLLTPLTEAAIFLVFTIDEGGEQAVHDVLADISGLQRSIGFRVPAGGLAAVVGIGSDAWDRLFEGPRPAELHPFVELTGDKHHAPRTPGDLLFHIRARQMDLCFEFATVVTNRLAGAASVIDEVHGFKYFEQRDLMGFVDGTENPSGQAAYVAVTVGDEDPDFAGSSYVIVQKYLHDMSEWNSLPVEEQENVIGRSKLEDLEMDDDTKPANSHTALTVIEDESGEQIQILRDNMPFGHVGSAEMGTYFIGYSASPTVTEQMLTNMFIGNPVGNYDRILDFSTAVTGINFFVPTADFLDDPPDAPTRLVPEATFTAPISDGSLGIGSLKRSAQQ
What is the function of this protein?
Cargo protein of a type 1 encapsulin nanocompartment (PubMed:24981030).  Has both general peroxidase activity and dye-decolorizing activity.  Can catalyze the oxidation of both protoporphyrinogen IX and coproporphyrinogen III to their corresponding porphyrins.  Also efficiently decolorizes the dyes alizarin red and Cibacron blue F3GA (By similarity).  This cargo-loaded encapsulin nanocompartment is probably involved in protection against oxidative damage (By similarity).
What are the official names of this protein?
Dye-decolorizing peroxidase, DypB.
What is the protein family that this protein belongs to?
Belongs to the DyP-type peroxidase family.
What are the subcellular locations of this protein?
Encapsulin nanocompartment.
Protein: DFB18_MOUSE
Sequence: MQSTMKMFGIILMVIFSVSCGPSAPQMKTREVAERTHKCSLVRGTCKSECNSWEYKYNYCHTEPCCVVREYKRMEKLLSTPKYTT
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 18, BD-18, mBD-18, Defensin, beta 18.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PEPE_SHISS
Sequence: MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTCDDYTAKTAAVLAPLGVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEAGHRF
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANAN_ANACO
Sequence: MTSKVQLVFLFLFLCVMWASPSAASCDEPSDPMMKQFEEWMAEYGRVYKDNDEKMLRFQIFKNNVNHIETFNNRNGNSYTLGINQFTDMTNNEFVAQYTGLSLPLNIKREPVVSFDDVDISSVPQSIDWRDSGAVTSVKNQGRCGSCWAFASIATVESIYKIKRGNLVSLSEQQVLDCAVSYGCKGGWINKAYSFIISNKGVASAAIYPYKAAKGTCKTNGVPNSAYITRYTYVQRNNERNMMYAVSNQPIAAALDASGNFQHYKRGVFTGPCGTRLNHAIVIIGYGQDSSGKKFWIVRNSWGAGWGEGGYIRLARDVSSSFGLCGIAMDPLYPTLQSGPSVEVI
What is the function of this protein?
Cysteine protease (PubMed:31306685).  Displays a high level of diversity in substrate specificity at the P1-P1' cleavage site (PubMed:31306685).  A hydrophilic P1 residue is preferred, with Gln or Arg strongly preferred (PubMed:31306685).  Favors an Ile/Leu residue at the P2 position of substrates, with an overall higher preference for Leu (PubMed:31306685).  The optimal tripeptide for cleavage is Pro-Leu-Gln, with cleavage occurring after the Gln residue (PubMed:31306685).  Another optimal tripeptide is Val-Leu-Arg, which may imply that a hydrophobic residue at the P3 position of substrates is preferred (PubMed:31306685).
What are the official names of this protein?
Ananain.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: DPS_CITK8
Sequence: MSTAKLVKTKASNLLYTRNDVSDSDKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALTDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHSVQDHLKELADRYSVVANDVRKAISEAKDEDTADIFTAASRDLDKFLWFIEANIE
What is the function of this protein?
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages.  It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
What are the official names of this protein?
DNA protection during starvation protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FER_DATME
Sequence: ATYKVKLVTPDGPVEFDCPDDVYILDRAEEEGHDLPYSCRAGSCSSCAGKVTAGTVDQSDGNYLDDDQMAEGFVLTCVAYPQSDVTIETHKEEELTG
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UREG_RHOP5
Sequence: MARYNGPLRVGIGGPVGSGKTALMDLLCKELRERYQIAAITNDIYTKWDAEFLVRSGSLTPDRIVGVETGGCPHTAIREDASMNLAAVADMRAKFPDLDLVLIESGGDNLAATFSPELADLTIYVIDVAAGDKIPSKGGPGITRSDLLVINKIDLAPYVGASLAKMEVDAKRMRGERPFVMTNLKQSAGLDRIIAFLEAKGGLQAEPVDA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_PEDPA
Sequence: MSKFIDPEKLEIEDRVVAINRVTKVVKGGRRLRFAALVVVGDKNGHVGFGTGKAQEVPEAIRKAVETARKSLIEVPIVGTTLPHEAVGVYGGGRILMKPALEGSGVAAGGAVRAVMELAGIDDVTSKRLGSNTAVNVVRATFEGLKSMRNAEEVAALRGVSVDHLAE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: TRI18_RAT
Sequence: METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMSSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECDLLIEIIQERRQIIGTKIKEGKVMRLRKLAQQIANCKQCIERSASLISQAEHSLKENDHARFLQTAKNITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWMIVPNIKQNHYTVHGLQSGTKYIFMVKAINQAGSRSSEPGKLKTNSQPFKLDPKSAHRKLKVSHDNLTVERDESSSKKSHTPERFTSQGSYGVAGNVFIDSGRHYWEVVISGSTWYAIGLAYKSAPKHEWIGKNSASWALCRCNNNWVVRHNSKEIPIEPAPHPRRVGILLDYDNGSIAFYDALNSIHLYTFDVALAQPVCPTFTVWNKCLTIITGLPIPDHLDCTEQLP
What is the function of this protein?
Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
What are the official names of this protein?
E3 ubiquitin-protein ligase Midline-1, RING finger protein Midline-1, RING-type E3 ubiquitin transferase Midline-1, Tripartite motif-containing protein 18.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Protein: CLPP_STAAR
Sequence: MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NELFE_DROME
Sequence: MVYIHFPNNLTEEEQMLQAKYQKLKKKKKALQAHKAPKPEPESSLTLKRPTDARDAREVARKLIKSGAIPAIQKQTKQDQTSFKRPKGQERAKRSTSETTVASYQPFSSTQNDVAQETIISEIIKEEPRRQNLYQHFATERDREERGMPEKVPMDTAQPEKPRAGNTIFVSGNKVTEDFLKKTFNDYGTIVNVSMEIEKSRGFVSFAKPESADRAIAEIHGKNVNGINLQVQLARRQPQIEPINDASSSAVWSSIAASKSQKGSHKDHREMVQYDEDFLL
What is the function of this protein?
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II.  The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing.
What are the official names of this protein?
Negative elongation factor E.
What is the protein family that this protein belongs to?
Belongs to the RRM NELF-E family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with polytene chromosomes. Associates with the hsp70 promoter when it is inactive, but not when it is activated. The NELF complex possibly dissociates from chromatin following phosphorylation of RNA polymerase II.
Protein: RL30_BACC3
Sequence: MAKKLEITLTRSVIGRPQDQRATVEALGLKKLNSTVVKEETPAILGMINKVSHLVTVKEA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: BL1S1_MOUSE
Sequence: MLSRLLKEHQAKQNERKELQEKRRREAIAAATCLTEALVDHLNVGVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIELDMRTIATALEYVYKGQLQSAPS
What is the function of this protein?
May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation.  May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit 1, BLOC-1 subunit 1, GCN5-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S1 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. Lysosome membrane.
Protein: RPOZ_NEIMA
Sequence: MARITTEDCTGKISNHFDLTLVAARRARQLENGNTPLVDDVRNNKPTVTALREIAAGHIGTELLTRNK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RUVC_AGRVS
Sequence: MTSAIRIIGIDPGLRRTGWGVIETLGNSLRFIASGTVMSDGDMDLASRLCQLHDGLADVVHLHQPDEAAVEQTFVNKDAVATLKLGQARGIAMLVPARAGLPVAEYAPNAVKKSVIGVGHGDKQQIHMMLKILMPKAEFKGNDAADALAIAICHAHNRGGERMRRALAG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: PAN_METMP
Sequence: MSYPDDYSTDIEKNKMDLKEFKEKTQIAELESKVLRLELKNKDINRENVQIKKENEILKRELDKLRIPPLILGTILDKVNERKAVVKSSTGPNFLVNLSQFVDPEDIVPGARVCLNQQTLAIVEVLPKEKDYRAMAMEIEEKPDISFEDIGGLNNQIRDIKEVVELPLKNPELFEKVGIVPPKGVLLYGPPGTGKTLLAKAVAYETNASFVRVVGSELVKKFIGEGAKLVRDVFKLAKEKSPCIIFIDEIDAVASKRTESLTGGDREVQRTLMQLLAEMDGFDSRGDVKIIAATNRPDILDPAILRPGRFDRIIEISMPDEDGRLEILKIHTEKMNLKGVDLREVAKIAENMVGADLKAVCTEAGMFAIREEREFIKMDDFREAISKITGKKEKCSYDMPQLTVMYG
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle.  Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.  Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
What are the official names of this protein?
Proteasome-activating nucleotidase, PAN, Proteasomal ATPase, Proteasome regulatory ATPase, Proteasome regulatory particle.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C5142_DICDI
Sequence: MNLIYTIILTIIILVLIISIKDLFFEDKIKKINKSIPSPPTIPIFGNLLQINSKDVATCFNDFYKQYGKVYRLRLGSVETVVLTGGDIIDECFNKKYRDFLKARYVKFSRYLGKDTNILHSNGDYHFLLKGVLSSQVTVRKLNNGRLEFNKYILQMFNNLNNNDEGSTMFLANDVPSQIKKLILKVVLNFTLGIEENDDINLSLFQNGSNIFKAAGLFIYSDYLPFLFPLDIKSMAKSNMISSYVFVRDYLAKKLEEVKKKEYIINGDDDGGVDTSQTPLIESYYKLYLQGLIGYDSILLSIVDIIIASVDTTSNSISFIIARLTNHQEIQSKIYEEIMSNDINNNSNNISFSDHSKYPYIISIMNETYRYYASVPLPEPNMTTEDIEVDGYKIAKGTQIYKNIRGTLISKEFWGEDALEFKPERFKTQTLNQKGLLHFGAGPRGCPGARFTECFFFTLMVLLFKNYKLQNPNDNPIDDRGDVGLSMQCKPYDALFIKRN
What are the official names of this protein?
Probable cytochrome P450 514A2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.