PharMolix/UniProtQA huggingface dataset:
Protein: ATPG_SHESM
Sequence: MAGAKEIKTKIASVKNTQKITSAMEMVAASKMRRAQDRMAASRPYAESMRKVIGHVAQGSLEYKHPYLEVREAKRVGYIVVATDRGLCGGLNVNLFKKVVADVKSWKEQGAEFEFCPIGARSVQFFKSFGGQVSAHASGLGDAPKLADLIGTVRVMLDAYNEGKLDRLYVVFNKFVNTMTQTPVIEQLLPLPKSEDDEVAHRWDYIYEPDPKALLDTLLVRYVESQVYQGVVENIASEQAARMVAMKAATDNAGTLIDDLQLVYNKARQAAITQELSEIVSGASAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AROE_DECAR
Sequence: MSDLYCVFGNPIAHSKSPAIHAAFAVQTAQDLRYEARLAALDGFGLAIAEFVAVGGKGANVTVPFKEEAYRLATRLSDRAARAGAVNTLVFDGPEVFGDNTDGAGLVRDITNNLGFSLVGKRILLLGAGGASRGVIAPLLAEKPASLIIANRSADKAVALAQAFADMAPLGGGSFAETAGKSFDLVINATSASLSGASLPLPPGIFAPGSLAYDMMYGKGETPFLTLARQQGAARCADGLGMLVEQAAEAFFVWRGIRPGTAQVLAELRAKLVA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: NHAA1_CAMJR
Sequence: MNNIVHKLKTLVLNEAFGGVLLIVCTLLALLVQNGSFSEHYREFLNLKVGFSVGEFELNKPFLLWINDGLISIFFFAIGLELKKEFLHGDFKNPKNIVLPFMAALGGILIPAMLFALVNIGDAYTLKGWAIPTATDTAFALAILMMCGKHIPSSLKIFLLSLAIFDDVGAILIIAIFYTTKLSIVAFVVAGLAILAMLILNLLGITRKSFYFICSVILWISVLKSGVHATLAGIVTAFFIPMQTKNGEAFLEEIYESLKFWIAFIILPLFAFANAGVNLSNIDIGAIFSGVSIGIFLGLFVGKQVGVFLFSYLAIRFKFAALPQGSNLKQLYGVCILTGIGFTMSLFIDGLAYEVSDIFNYADNLAILIASFCSGIWGFIYLKFFTTRS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCD51_ORYSJ
Sequence: MEAEDEYSAGCSFSLMCQEDSTDLDDDGGGGGCFAGDGRADLLLVYNAAAAADDEDEEEVEEYMDHLVSKESSFCSSSSSTSSSSCCFSDAGGESAAAAAPMDWFALARRATVKWILETRGCFGFCHRTAYLAIAYFDRFCLRRCIDRSVMPWAARLLAVACVSLAAKMEEYRAPALSEFRAGVGDDGYEFSCVCIRRMELLVLSTLDWRMAAVTPFDYLPCLSSRLRRHVGGGGGAGASAALIFSAAEAASVLDHRPSTVAAAAVLAATHGALTREALESKMSGLSPSFLLDKEDVFACYSAMLSQPTSPASKSTTTTTGKRSSSSSCSESTDAASSYDATAASFPAAASCGSKRMRLELPGGILR
What are the official names of this protein?
Cyclin-D5-1, G1/S-specific cyclin-D5-1, CycD5;1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
Protein: ACPS_CHLFF
Sequence: MQMAHIGTDIIEIARIRKAIETHNQRMLNKIFTKKEQEYCLRLTNPYPSFAARFAGKEAVAKALGTGIGKVIGWKDIEILTSPKQPKVHLPPRVYKELGISKVLLSISHSREYATAMAVALV
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_DESPS
Sequence: MKIHEYQAKQLFRKYSIPVPEGLLCTNLQEVKTALKSLQLPIAVKAQIHAGGRGKGGGVKLGKTATEVVQYADDILGMSLVTAQTGPSGRTVSKILLEEGVSIARELYLSILVDRERACITIIACQDGGMNIEEVAASTPERIGKIHINPLIGPRSYHINQAREWLNIAQEQARAFSLFIHALYKLFLDYDCSMVEINPLIITEDNQLIALDAKVDTDSNALFRQRELQKMHDPAEDDPAEAEAAKFNLNYIKLSGNVGNMVNGAGLAMATMDIIKRAGAEPANFLDVGGSADAERIENGFRIILADTNVKAILINIFGGILRCDILAQGVVQAAAKVSLQVPVVIRMEGTNVKEGREILAKSGLSLINATDLNDAAEKISTLLTD
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: PSTB_HYDCU
Sequence: MSEQNMSIAIDRHHRGMTLDSEQTAIVVKNWNLYYGSKQALHNITMKLPQNRVTAFIGPSGCGKSTLLRCFNRMNDLIDIVSVEGEMLLHGENMYAKEMDVAALRRRVGMVFQKPNPFPKSIYENVCYGLRLQGINDKNVLDETVEWALKGAGLWEEAKDRLDENALGLSGGQQQRLCIARAIAIKPEVLLLDEPTSALDPISTLAIEELIFELKKDFTILIVTHNMQQAARVSDYTAFMYMGDLIEYTDTDSLFTNPQVKRTEDYISGRYG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TRUA_SHEPA
Sequence: MRVALGIEYDGSQYFGWQRQAEVDTVQERLEKALSIVANEPIAVHCAGRTDAGVHATGQVVHFETNAIRKETAWTLGVNVNLPDNIAVRWVKVVDDEFHARFTATARRYRYMIYNHQLRPGILRSGVSHYPGDIDESKMHQAAQYLLGEQDFTSFRAVHCQSNTPFRCVHEVNVTRQGMYICVDIKANAFLHHMVRNIVGSLLEVGLGNQSVEWIEQLLALKDRNKAAATAKPNGLYLVDVTYPESYQLPKLSLGPLFMLD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: EFG_STAAN
Sequence: MAREFSLEKTRNIGIMAHIDAGKTTTTERILYYTGRIHKIGETHEGASQMDWMEQEQDRGITITSAATTAAWEGHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQANAAPIQLPIGAEDEFEAIIDLVEMKCFKYTNDLGTEIEEIEIPEDHLDRAEEARASLIEAVAETSDELMEKYLGDEEISVSELKEAIRQATTNVEFYPVLCGTAFKNKGVQLMLDAVIDYLPSPLDVKPIIGHRASNPEEEVIAKADDSAEFAALAFKVMTDPYVGKLTFFRVYSGTMTSGSYVKNSTKGKRERVGRLLQMHANSRQEIDTVYSGDIAAAVGLKDTGTGDTLCGEKNDIILESMEFPEPVIHLSVEPKSKADQDKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEFNVECNVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEFENAIVGGVVPREYIPSVEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASLALKEAAKKCDPVILEPMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQVVNAYVPLSEMFGYATSLRSNTQGRGTYTMYFDHYAEVPKSIAEDIIKKNKGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).  Has vitronectin-binding activity.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_MYCPN
Sequence: MIDQSKLIERWKTTFETAQNPTELLAFKNSFRNADLKPLLSQIKETTDIETKRHLGQLYKQLESTLQTLHDTQLQVFTQAQSSSVLTHGDVMLLATSFAPGSSNIIYQVIDELVNYFKKFLFTVNYDSELTTIADCFDLLNIPKDHPSRNLTDTFYLDKNRLLRTHCTAATLRAVKETKKSNNPDIRIASFGAVFRKDDDDATHSHQFNQLDFMWIKKDFSLTNLKWFMQNMINHIFGENTSARFRLSHFPFTEPSFEIDIRCWLCQNGCGVCKKTRWIEVLGAGILHPQVMANMGFSDTDNIRGIAAGIGIERLVMLKHGISDIRDLYDNNFKFLAQFTD
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSH6_SCHPO
Sequence: MSVGNVGKQREKTKDSSAKTKQKTLFGFFSKIPNVKQEKSDSTLSSSSNHDSNHDTPADVDNSSNVNKNSSSPERELPTSPSHHANTEIDSSSSMLPPPSSDPFSSPLSSSLHRSSPKRPHDSLGEESPGKLLRTSVKQEPDSEEEIDSPTKKKSFKSLDTSIFQAEDQFRHPVSSKLENSELSEVDKPFIASRRSRKPVSYAESDEDEDFDDAPTKGSRHKRIVSDDESDDYVEPDHISEASSEASLPIDEVESMDEDVDGYSDHSVSVAAPIPKKESRKESSNSLYESYRLGSQIASPSPSVSGSASPTKSNKNGVLNREEKRRQRMEAFKKENNERYEWLLDVRDADQNRVGDPNYDPRTLYIPPSAWATFKPFEKQFWKIKKDLMDTVVFFQKGKFYELYENDAAIGHQVFSLKLTDRVNMKMVGIPEASFDYWASQFIAKGYRIARVDQLETALGKEIKDRQRTQKEEKVVQRGLTQVLTSGTLVDEAMLTSDLSTYCMAIKESLQSDNEEPSFGICFIDTSTGGFHMCEFTDDIHRTKLDTLLTQVRPKELILEKSKISQKSIRAIKYCVSSSSIWNFIKPYTEFWDNERVEREIIAGDYFKNGLEGAPKILKSYLSEKPLAISAFGALFWYLRQLKLDKDMCSMGNFDEYDASQQSTSLLMNGQTLKNLEIFSNSFDGGSEGTLFHLLCRCVTPFGKRLFHTWLCHPLRSGTAINARLDVVELIADNPVIRDTIWGFLHKLPDLERLISRVHAGRSKPADFVRVLEGFQRINSAFDQLREEFMEVAEGTLLGEIIQSAPNMKEELEAWTRAFNWQKASEEGVFEPEIGFEAEYDTSQKYQSELKNELYALLEQYKKQLRCSSLNFKNIGKEVYQVEVPSDVKVPVNWCKMSGTKKTNRYYNDELRKKIKKLLEAEELHLAIMSRMQEKFYIRFDSNYEQWLALIKYTASIDCFFSLSQAAAALGEPYCRPEIIEQKDGHLYFEELRHPCINASAASTFVPNDVVLGGESPNMIVLTGPNMAGKSTLLRQVCIAVIMAQLGCWVPAKRASITPMTSIYTRLGANDDIMSARSTFMVELSETKKILDECGPKSLVILDELGRGTSTYDGHAIAYAVLHHLVSNIGCLGFFSTHYQSLCVDFMHHRQVRLMQMAAAVDEKIRRVTFLYKLEDGICPKSYGMNVASMAGLPEKVIDAAEEKASELEQASASFINASDDIALMSDFLQVLRISKSIEPLTAVNIPLILDSFE
What is the function of this protein?
Involved in post-replicative DNA-mismatch repair.  Has a role towards base-base mispairs and insertion-deletion loops.
What are the official names of this protein?
DNA mismatch repair protein msh6.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SNAA_VITVI
Sequence: MADNIQRGEEFEKKAEKKISGWGLFGSKYEDAADFYDKAANCFKLAKSWDRAGSTYVKLSTVIQSSDSKHEAAQAYADAGHCYKKTSAKEAISCLEQAAYLFLDNGRFNMAGKYYKEIAELYELEQNFEQAIIYFEKAADIYQSEEATTAANQCNAKVAQFAAQLEQYQKAIQIYEDIGRPSLNNNLLKYGVKGHLLNAGICQLCKGDVVAITNALDRYQEMDPTFSGTREYKLLVDLAAAVDEEDVVKFTDAVKEFDSMTQLDAWKTTLLLRVKEAIKAKELEEDDLT
What is the function of this protein?
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
What are the official names of this protein?
Alpha-soluble NSF attachment protein, Alpha-SNAP, N-ethylmaleimide-sensitive factor attachment protein alpha.
What is the protein family that this protein belongs to?
Belongs to the SNAP family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: CAPON_RAT
Sequence: MPSKTKYNLVDDGHDLRIPLHNEDAFQHGISFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSDGSGDPGRQLTGAERVSTATAEETDIDAVEVPLPGNDILEFSRGVTDLDAIGKDGGSHIDTTVSPHPQEPMLAASPRMLLPSSSSSKPPGLGTGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQSTMGSQDSLLEITFRSGALPVLCESTTPKPEDLHSPLLGAGLADFAHPVGSPLGRRDCLVKLECFRFLPAEDNQPMAQGEPLLGGLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQELGDSLDDEIAV
What is the function of this protein?
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1.  The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level.  Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1.  Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4.  In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862).
What are the official names of this protein?
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein.
What are the subcellular locations of this protein?
Cell projection, filopodium. Cell projection, podosome.
Protein: ENOB_MOUSE
Sequence: MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKARYLGKGVLKAVEHINKTLGPALLEKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLVLPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLDFKSPDDPARHISGEKLGELYKNFIQNYPVVSIEDPFDQDDWATWTSFLSGVDIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAVFAGRKFRNPKAK
What is the function of this protein?
Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate.  Appears to have a function in striated muscle development and regeneration.
What are the official names of this protein?
Beta-enolase, 2-phospho-D-glycerate hydro-lyase, Enolase 3, Muscle-specific enolase, MSE, Skeletal muscle enolase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity).
Protein: CYB_TAMCA
Sequence: MTNIRKTHPLIKIINHSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTYFETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVMVHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDILGILLLILVLMILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILMLFPILHMSKQRSMMFRPLSQCMFWILVADLFTLTWIGGQPVEYPFIIIGQLASILYFMIILLILPAISLFENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BAMD_CAUVC
Sequence: MLRIFQGRPAVTIAAVLVAASVAGCAGKAKKPTLVYEERPVELLYSTGADRLDRGNWNEAVDYFREVERQHPYSEWSRRSILMTGYAHYMGNQYAEAIGDADRFISLYPGNPSAQYAFYLKAICYFEQIVDVNRDQAATEQALAALRDVVQRYPNTEYATDARLKIDMVNDQLAGKEMAIGRWYLKNGQTLAAIGRFKAVIERHQTTSHTPEALFRLVEAYLTIGLNEEAKRNGAVLGYNFPGDRWYVDAYRLLNDNGLRPAVEPLKAGAKRNALERILSKDKEATLAPPGERKAKKGLLGPLGM
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamD.
What is the protein family that this protein belongs to?
Belongs to the BamD family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RL32_BRUME
Sequence: MAVPKRKTSPSRRGMRRSADALKAPTYVEDKNSGELRRPHHIDLKSGMYRGRQVLEPKE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RL34_PHEZH
Sequence: MKRTFQPSRLVRKRRHGFRLRMSTKNGQKILARRRAKGRKRLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RS16_MYCMS
Sequence: MVKLRLKRIGKKQAPFYRIVVADSRVNRNGQYIELVGTFNPLKDEVKIDNELTLKWLNNGAQPTDTVRSLLSKQGILKALHESKFSKNTQTENKKPVSKKTTKKSKDN
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SYY_LACDA
Sequence: MANFDILEDLKWRGAINQETDEEGLRDYLAKHDDLALYCGTDPTGDSLHIGHLIPFMILKRFQLAGYKPVIVIGGGTGSIGDPSGRSTERVLQSEETIKHNEEALTAQMVKLFGTENFRIVNNRDWLGKMNLLEFLRDYGKLFQVNNMLNKEVVASRLKNGISFTEFSYQILQAIDFYILNRDHCVQMQIGGADQWGNITAGIDLIHRLEGADRPAFGLTIPLMLKADGTKFGKSAGGAVWLDPEKTSPYEFYQFWINQDDRDVIKYLKYFTFLKHEEIDALEEKVKTEPWKREAQKRLAEEVTKFVHGEEGLKEAQTVTEALFSGNVKDLTTKQVEIALAKAPSAESGAEKKNLVDFLVDTKIESSKRQAREDVNNGAIYVNGDRIQDTDFEVDPAAAFDGKFVIIRKGKKKYTLVHIKG
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTAM_PESFW
Sequence: MSVPAQTSVLIVGGGPAGSYAATVLAREGVDVVLLEAEKFPRYHIGESMLASIRFFLRFVELEEEFDRHGFEKKYGATFKITEKNPAYTDFAASLGEGGYSWNVVRSESDEIIFRYAGKCGAKTFDGTKVESLTFEPYPHEGFDESVHLANPGRPVSANWSRKDGSSGVIKFDYIIDGSGRNGLISTKYLKNRSFNQGLKNIANWTYWKGAKRFNVGEKNENSPLFEALKDGSGWVWAIPLHNDTISVGVVARQDAFFEKKKESGLSGEAFYKEYLKLAPQIKNELLRDATIVSDIKQATDWSYSASAYAGPNFRLIGDAGCFVDPYFSSGCHLAMTSALSASVSIQAVRRGQCDELTGAKWHTTKVAEGYTRFLLLVMTVQRQLRMKDKNIISTDEEEGFDMAFKKIQPVIQGVADTRTEDEQTQRRAAEAVDFSLESFEITPEKQAAVISKIERSQAEPELLEKLTPEEVHILGNIVNRTFEREKDELNLTHFTGDMIDGYSAKLEHGNIGLYKREKALLNGTASRAAAVLKSIHQVA
What is the function of this protein?
Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes (PubMed:24302702).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS ptaA (PubMed:24302702).  As the ptaA protein is TE/CLC domain-deficient, hydrolysis and Claisen cyclization of the polyketide could be catalyzed by ptaB containing a beta-lactamase domain (PubMed:24302702).  The ptaB protein might hydrolyze the thioester bond between the ACP of ptaA and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrated to form endocrocin anthrone (PubMed:24302702).  Endocrocin anthrone is then converted to endocrocin, catalyzed by the anthrone oxygenase ptaC (PubMed:24302702).  Spontaneous decarboxylation of endocrocin occurs to generate emodin (PubMed:24302702).  An O-methyltransferase (ptaH or ptaI) could methylate emodin to form physcion (PubMed:24302702).  PtaJ could then catalyze the oxidative cleavage of physcion, and rotation of the intermediate could then afford desmethylisosulochrin (PubMed:24302702).  PtaF, a putative NADH-dependent oxidoreductase, might also participate in the oxidative cleavage step (PubMed:24302702).  Desmethylisosulochrin is then transformed by another O-methyltransferase (ptaH or ptaI) to form isosulochrin (PubMed:24302702).  Chlorination of isosulochrin by ptaM in the cyclohexadienone B ring then produces chloroisosulochrin (PubMed:24302702).  PtaE is responsible for the oxidative coupling reactions of both benzophenones isosulochrin and chloroisosulochrin to RES-1214-1 and pestheic acid respectively, regardless of chlorination.
What are the official names of this protein?
Flavin-dependent halogenase ptaM, Pestheic acid biosynthesis cluster protein M.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: UPP_CITBB
Sequence: MSVHEVNHPLVKHKIGLMREAGISTKKFRELTSEIACLLAYEASRDFQIEPRTITGWDGSKVMIQQLKGKKVTVVPILRAGIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYFERFVGSLDERLALIIDPMLATGGSMAATIEMLKKNGCLQIRVLCLVAAPEGLAKITAAYPEIDIYVAAIDERLNEQGYILPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: CAS4_SACS2
Sequence: MITEFLLKKKLEEHLSHVKEENTIYVTDLVRCPRRVRYESEYKELAISQVYAPSAILGDILHLGLESVLKGNFNAETEVETLREINVGGKVYKIKGRADAIIRNDNGKSIVIEIKTSRSDKGLPLIHHKMQLQIYLWLFSAEKGILVYITPDRIAEYEINEPLDEATIVRLAEDTIMLQNSPRFNWECKYCIFSVICPAKLT
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).  This protein is a 5' to 3' partially processive exonuclease that cleaves off single mononucleotides.  Has a marked preference for ssDNA, although in vitro it also acts on dsDNA and ssRNA.  Has low endonuclease activity with circular ssDNA.  Binds ssDNA and can unwind dsDNA; unwinding does not require ATP.
What are the official names of this protein?
CRISPR-associated exonuclease Cas4.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated exonuclease Cas4 family.
Protein: SUB2_TRIRU
Sequence: MQLLNFGLLLLPFVAGDLAPQPEPLLVGPSDIVPGQYLVTLKEGLTSAQIRDHKKWVSSVHRANLDSFAAGARGVETEGIMKHFHIHDLNMYSGGFDEKRVEDLSRSPYVKSVHPDQHFYLAKTVTQRQARWGLGYMSSKGKPVPLHSTLVDYSYDDKAGEGVWAYVLDTGINVNHVEFEGRAILGHNAIPNKSHTDEFGHGTCVAGIIAGKTYGVAKKANVVSAKAFDTGSSTYNYILETYDWIIRNITDSNRKNKAVINLSISGAKYQPFDDAAERAFKAGITTVVAAGNDGKDAKNNTPASSPNAITVGAVRWENTRPSFSNYGKIVDIWAPGELIKSCWKGGNNATSTQSGTSAASPHVAGLVAYLMSIKNLPSPSAVTARVLNLTIPNLVKDAKDSPNRVVYNGIQERKCKLPKYY
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RRF_PROM2
Sequence: MKEKEIQENMNKSIEATQRNFNTIRTGRANASLLDRVSVDYYGAETPIKSLATISTIDSQTISIQPFDISCLQAIEKSISMSDLGITPNNDGKVIRINVPPLTEERRKEFCKLASKYAEEGKVALRNIRRDAVDKEKKDEKDGLISIDESRDNQSEIQKITDKYIALIETKLSEKEKEILKV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: E3145_ADE06
Sequence: MTESLDLELDGINTEQRLLERRKAASERERLKQEVEDMVNLHQCKRGIFCVVKQAKLTYEKTTTGNRLSYKLPTQRQKLVLMVGEKPITVTQHSAETEGCLHFPYQGPEDLCTLIKTMCGIRDLIPFN
What is the function of this protein?
Protects virus-infected cells from TNF-induced cytolysis.
What are the official names of this protein?
Early E3B 14 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E3_15 family.