PharMolix/UniProtQA huggingface dataset:
Protein: HEMY_ECOL6
Sequence: MLKVLLLFVLLIAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILILAMVVLFAIEWLLRRIFRTGAHTRGWFVGRKRRRARKQTEQALLKLAEGDYQQVEKLMAKNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAELAGNDTIPVEITRVRLQLARNENHAARHGVDKLLEVTPRHPEVLRLAEQAYIRTGAWSSLLDIIPSMAKAHVGDEEHRAMLEQQAWIGLMDQARADNGSEGLRNWWKNQSRKTRHQVALQVAMAEHLIECDDHDTAQQIIIDGLKRQYDDRLLLPIPRLKTNNPEQLEKVLRQQIKNVGDRPLLWSTLGQSLMKHGEWQEASLAFRAALKQRPDAYDYAWLADALDRLHKPEEAAAMRRDGLMLTLQNNPPQ
What is the function of this protein?
Involved in a late step of protoheme IX synthesis.
What are the official names of this protein?
Protein HemY.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PORTL_VZVD
Sequence: MAEITSLFNNSSGSEEKRIASSVSIDQGLNGSNPNDQYKNMFDIYWNEYAPDIGFCTFPEEDGWMLIHPTTQSMLFRKILAGDFGYTDGQGIYSAVRSTETVIRQVQATVLMNALDATRYEDLAADWEHHIQQCNLHAGALAERYGLCGESEAVRLAHQVFETWRQTLQSSLLEFLRGITGCLYTSGLNGRVGFAKYVDWIACVGIVPVVRKVRSEQNGTPAPLNTYMGQAAELSQMLKVADATLARGAAVVTSLVECMQNVAIMDYDRTRLYYNYNRRLIMAKDDVTGMKGECLVVWPPVVCGEGVVFDSPLQRLSGEVLACYALREHARVCQVLNTAPLRVLIGRRNEDDRSHSTRAVDRIMGENDTTRAGSAASRLVKLIVNLKNMRHVGDITETVRSYLEETGNHILEGSGSVDTSQPGFGKANQSFNGGAMSGTTNVQSAFKTSVVNSINGMLEGYVNNLFKTIEGLKDVNSDLTERLQFKEGELKRLREERVKIKPSKGSHITMAEETRIADLNHEVIDLTGIIGDDAYIANSFQSRYIPPYGDDIKRLSELWKQELVRCFKLHRVNNNQGQEISVSYSNASISLLVAPYFSFILRATRLGFLVTQSEVHRSEEELCQAIFKKARTESYLSQIRILYEMQVRAEVIKRGPRRTPSPSWGLPDPTEDDERIPEPNKINNQYMHVGYKNLSHFMKGHPPERLRVHKVNAADSTLLDKIRANRRRGDGRWDVRNKYTQHFRLQRNDRQLTNTSRRGVGCERRDRRS
What is the function of this protein?
Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging.  Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid.  Binds to the molecular motor that translocates the viral DNA, termed terminase.
What are the official names of this protein?
Portal protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae portal protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: DDL_STRPJ
Sequence: MKQTIILLYGGRSAEREVSVLSAESVMRAVNYDRFTVKTFFISQSGDSIKTQEFSHAPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSVQGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEVEEKLAYPVFTKPSNMGSSVGISKSENQEELRQALKLAFRYDSRVLVEQGVNAREIEVGLLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKVTMDIPAKISDDVVAVMRQNAETAFRAIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWENMGISYPELIERLVDLAKESFDKREAHLI
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPS_ROSDO
Sequence: MHRDLHMMSDRSEDDGDTSILTATKPKTKRPPLYKVLLLNDDFTPMEFVVHVLERFFGLNHAQAFEIMLTVHKKGVAVVGVFSHEIAETKVAQVMDFARRHQHPLQCTMEKEE
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RL1_SODGM
Sequence: MAKLTKRMRVIRDKVDSTKQYDISEAVALLKELATAKFVESVDVAVNLGIDARKSDQNVRGATVLPHGTGRSVRVAVFTQGANAEAAKAAGADLVGMDDLADQIKKGEFNFDVVIASPDAMRVVGQLGQILGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFESDKLKENLEALLVALKKAKPTQAKGVYIKKVSLSTTMGAGVAVDQSGLSTTTA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: UPP_FRATH
Sequence: MKVVEISHPMVKHKLGLMRAASISTQEFRRLTKEITSLLTYEVTAGFELEKTEILGWQGENIEIDQIKGKKLTVVPILRAGLGMMDGVFEHVPAAKVSMVGMYRDEKTAKPVAYFAKLCDKLDERVALIVDPMLATGGSMIATVSLLKKAGSKDIKIITLVSAPEGIDTLAKAHPDVELYTASIDSHLNDKKYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: Y409_METJA
Sequence: MKKLIFVVLLLAVISYTYPSNLDYKYTSSIPIEFVKLSEIKNVDELNRLLNSNALVIFCLDSNNINKDILYHLGIKRYNPSEIPDYGNYSYVSINGVIVVYPKYSVYEENGALIYNPPKEENYSKYEFVRPYKIKVPNVSKIPDYGGYVLIENSTFILYPKKYIIRGDEGGIYYIPPKNSSDNYYYKYSYNLPEKCIPDYYDYVFIDNNGIFIIYPKKYVVRSNDGVLVFSPPVDAKEAPIYKIDYKKIDEGVYEIKKNKLLFLYPTTLNNKSTLDIIGEYIAKNGGVFAYINKVPPYYKHMLATGVAIDKVIPDESGSYAIDVAGRKIKVDVLDDEIINNKLKCIKALKALGINVSYIVTGSEGIDIVEKSNVDTDELEDLYNYYWFKKWWQNYTHLYFNPSQLKNIEFNGFEDILALSYYPLIYVDKAPETFRNDPIGGYYPKVISYKGTKNYGYWEEGAKSENVYYHLDEGEPYWDGKANEPSKWYYEGQPVSMENDSEMWNRYEYFNHWFVKNYAYALANGCDGLFLESSDKNLIDAIFGNDNENLSWKLDIKNKVDYVVIPGNKGFEVINGIPVIRIPSPLKEVYGANVINTLYIPPKDEDFGIYISDIRNYNTNLVVELKENGTDIVSFKDLADWLNKYYRNNIFYNGTAIKIWDNRGIKITIFKKNFGMGNYTFEEFDKEHCKYVIVNPPKIIPLK
What are the official names of this protein?
Uncharacterized protein MJ0409.
Protein: ECFA1_LACP3
Sequence: MGNVIRVQHLNYTYPEAKQQALTDVSFDVAKGEWLAIIGHNGSGKSTLAKNLNGLLAPESGTVQVAGMTLSEETVWDIRAKVGIVFQNPDNQFVGATVADDVAFGLENRGVPRPEMIKRVDEALDRVGMTAFADREPARLSGGQKQRVAIAGIVAQRPEIIILDESTSMLDPAGRQEVLGVIRELKDELGLTVLSITHDIDEAAEAHRIILLNDGKINEIGTPSEIFSHGMELLRLGLDVPYSEKLKDALAQRGIAMPKDYMDNERLVDYLWTLHSTM
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates including 5-formyltetrahydrofolate and thiamine.  Expression of the complex plus FolT or ThiT in Lactococcus lactis subsp.  cremoris (strain NZ9000) allows 5-formyltetrahydrofolate or thiamine uptake respectively; 5-formyltetrahydrofolate or thiamine are not taken up in the absence of FolT/ThiT or the EcfA1A2T complex.  Deenergized L. lactis subsp.  cremoris (treated with 2-deoxyglucose) does not take up substrate.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NUOC_STRM5
Sequence: MAEQASFIDRLSARFAGAKVIVVEPRGEVTLEVPAAEWHATALALRDEFGFEQAVDLCGVDYLGYGSDEWDTADVSSQGFSRGVEGKAQGRFAWGEFPTEENGADGARPQHMPTQRFAVVAQLRSYQHNLMMHLRCFAPDEALPVVSSLTGIWPGLNWFEREAFDLYGVIFEGHPDLRRILTDYGFVGHPFRKDFPLIGNVEVRYDEEKKRVIYEPVTSVEPRVGVPRVIRDDARLQTAEGERAQEAVK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CBPD_PSEAE
Sequence: MKHYSATLALLPLTLALFLPQAAHAHGSMETPPSRVYGCFLEGPENPKSAACKAAVAAGGTQALYDWNGVNQGNANGNHQAVVPDGQLCGAGKALFKGLNLARSDWPSTAIAPDASGNFQFVYKASAPHATRYFDFYITKDGYNPEKPLAWSDLEPAPFCSITSVKLENGTYRMNCPLPQGKTGKHVIYNVWQRSDSPEAFYACIDVSFSGAVANPWQALGNLRAQQDLPAGATVTLRLFDAQGRDAQRHSLTLAQGANGAKQWPLALAQKVNQDSTLVNIGVLDAYGAVSPVASSQDNQVYVRQAGYRFQVDIELPVEGGGEQPGGDGKVDFDYPQGLQQYDAGTVVRGADGKRYQCKPYPNSGWCKGWDLYYAPGKGMAWQDAWTLL
What is the function of this protein?
Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity.
What are the official names of this protein?
Chitin-binding protein CbpD, Protease LasD.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in an Xcp-dependent fashion (a type II secretion pathway).
Protein: RK32_CALFG
Sequence: MAVPKKRTSVSKKHIRRNIWKRKGYRAASKALSLAKSISTGHSKSFFVRQTSNKALE
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MNS1B_ASPFU
Sequence: MHLPSLSVALALVSSSLALPQAVLPENDVSSRAAAVKEAFSHAWDGYMKYAFPHDELLPVSNSYGDSRNGWGASAVDALSTAIVMRNATIVSQILDHIAKIDYSKTSDMVSLFETTIRYLGGMLSGYDLLKGPAADLVEDRTKVDMLLQQSKNLGDVLKFAFDTPSGVPYNNINITSHGNDGATTNGLAVTGTLVLEWTRLSDLTGDQEYAKLSQRAESYLLAPQPSSGEPFPGLVGSAISIQTGQFTNGFVSWNGGSDSFYEYLMKMYVYDPKRFATYKDRWVAAAESSIDHLASNPASRPDLTFLATYNKGSLGLSSQHLACFDGGSYLLGGTVLDRADLIDFGLKLVDGCAETYHQTLTGIGPESFGWDEKSVPADQKELYERAGFYVQSGAYILRPEVIESFYYAYRVTGKKQYRDWVWNAFENINKYCRTESGFAGLTNVNAVNGGGRYDNQESFLFAEVMKYAYLTHAPGMSSMPAAAEDKANKSRG
What is the function of this protein?
Involved in the maturation of Asn-linked oligosaccharides.  Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (By similarity).
What are the official names of this protein?
Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B, Class I alpha-mannosidase 1B, Man(9)-alpha-mannosidase 1B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle lumen.
Protein: TTDA_SHIBS
Sequence: MMSESNKQQAVNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNMQKAIDLNRPACQDTGEIMFFVKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAVEIFDEVNTGKNTGSGVPWVTWDIIPDNDDAEIEVYMAGGGCTLPGRSKVLMPSEGYEGVVKFVFENISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNRLGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLTFENLSHTRSAL
What are the official names of this protein?
L(+)-tartrate dehydratase subunit alpha, L-TTD alpha.
What is the protein family that this protein belongs to?
Belongs to the class-I fumarase family.
Protein: CYSC_SHESM
Sequence: MSNIVWHQHSVDQAARAKLKGQNPVLLWFTGLSGAGKSTLAGALERALFEAGFHTYLLDGDNVRHGLCKDLGFSVADRDENLRRVGEVAKLMVDAGLVVLSAFISPTREERDSIRARFPTGQFIEVHVSTPLSICEQRDPKGLYVKARRGEISNFTGISSPYEAPLSAELTIDTSKGDLASQVRALIDYLTAIEVINPSRLTASA
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: RL7_DELAS
Sequence: MAFDKDAFLTALDGMTVLELNDLVKAIEEKFGVSAAAMAAPAAGGAAGGAAAAEEKTEFNVVLTEAGANKVSVIKAVREITGLGLKEAKDLVDGAPKNVKEGVAKADAEAAVKKLVEAGAKAELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: EVA1B_HUMAN
Sequence: MDAPRRDMELLSNSLAAYAHIRANPESFGLYFVLGVCFGLLLTLCLLVISISWAPRPRPRGPAQRRDPRSSTLEPEDDDEDEEDTVTRLGPDDTLPGPELSAEPDGPLNVNVFTSAEELERAQRLEERERILREIWRTGQPDLLGTGTLGPSPTATGTLGRMHYY
What are the official names of this protein?
Protein eva-1 homolog B, Protein FAM176B.
What is the protein family that this protein belongs to?
Belongs to the EVA1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RISB_PSEA8
Sequence: MTLKTIEGTFIAPKGRYALVVGRFNSFVVESLVSGAVDALVRHGVAESEITIIRAPGAFEIPLVTQKVAQQGGFDAIIALGAVIRGGTPHFEYVAGECTKGLAQVSLQFGIPVAFGVLTVDSIEQAIERSGTKAGNKGAEAALSALEMVSLLAQLEAK
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: TAT_HV1ZH
Sequence: PLPTTRGNPTGPKESKKEVESKTETDPFAW
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Tat seems to inhibit the HAT activity of KAT5/Tip60 and TAF1, and consequently modify the expression of specific cellular genes.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines (such as IL10) or cytokine receptors.  May be involved in the derepression of host interleukin IL2 expression.  Mediates the activation of cyclin-dependent kinases and dysregulation of microtubule network.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Host extracellular matrix metalloproteinase MMP1 cleaves Tat and decreases Tat's mediated neurotoxicity.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.  Binds to KDR/VEGFR-2.  All these Tat-mediated effects enhance angiogenesis in Kaposi's sarcoma lesions (By similarity).
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type (By similarity).
Protein: NCAP_PI4HB
Sequence: MSSVLAAYEQFLQTTEDRSFGDQQFVQSDTLKAEIPVFVLNTNDPQQRFTLMNFCLRLAVSSSAKSAIKQGALLSLLSLQATSMQNHLMIAARAPDAALRIIEVDAIDPQDYTLTINPRSGWDDIKIRAYRALSRDLPISLADRTVFVSRDAEHAVCDDMDTYLNRIFSVLIQIWIMVCKCMTAYDQPTGSEERRLAKYKQQGRMLEKYQLQTDARKIIQLVIRESMVIRQFLVQEMLTADKVGAYTNRYYAMVGDIAKYIANVGMSAFFLTLKFGLGNRWKPLALAAFSGELVKLKSFMSLYRRLGDRSRYLALLESPELMEFAPANYPLLFSYAMGVGSVQDPLIRNYQFGRNFLNTSYFQYGVETAMKHQGTVDPKLALELGITDEDRVDIMQSVEKHISGKAGDDISQPAGAFTMSLSRSAFINNNTSQDFSGARLSNYEQGWSGTNQDETRDVYPESTMHRLQNIEPTDSDHNELLMPELESDSNPFNRPRFTVRAPLIPEISHQNPTTRMNRNINTRDNTRADHQDTNEDRGSNVPDDILGDLDN
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The nucleocapsid (NC) has a helical structure.  The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.  During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NP, Protein N.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses nucleocapsid family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: CCMC_ARATH
Sequence: MSVSLLQPSFLMSKTRSYAQILIGSWLFLTAMAIYLSLGVAPLDFQQGGNSRILYVHVPVAWMSIIVYIATAINTFLFLLTKHPLYLCSSGTGIEMGAFFTLFTLVTGGFWGRPMWGTFWVWDARLTSVFILFFIYLGALCFQKLPVELASILICVGLIDIPIIKFSVNWWNTLHQPGSISRFGTSIHVSMLIPILSNFANFLFLTCILFVLETRLLILSFLESSITEEIEA
What is the function of this protein?
May be involved in the export of heme to the mitochondrion for the biogenesis of c-type cytochromes.
What are the official names of this protein?
Putative cytochrome c biosynthesis ccmC-like mitochondrial protein, ABC transporter I family member 3, ABC transporter ABCI.3, AtABCI3.
What is the protein family that this protein belongs to?
Belongs to the CcmC/CycZ/HelC family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: DER_YERPN
Sequence: MIPVIALVGRPNVGKSTLFNRLTHTRDALVADFPGLTRDRKYGRAEVEGHEFIVVDTGGIDGTEDGVETKMAGQSLLAIEEADIVLFMVDARAGLMPADQGIAQHLRSREKATFLVANKTDGIDPDTATADFYSLGLGEVHAIAASHGRGVTQLIEDVMAPYMDAEEPEVELTEEEENAAYWAEQEAQGEDVPPEDPEDDFDPRTLPIKLAIVGRPNVGKSTLTNRILGEDRVVVYDMPGTTRDSIYIPMTRDDREYILIDTAGVRKRGKITETVEKFSVIKTLQAIEDSNVVLLVIDARDGISDQDLSLLGFILNSGRSLVIAVNKWDGMTEEARAQVKDMLDLRLGFVDFARIHFISALHGSGVGNLFESVQEAYDCSTKRVGTSLLTRIMQMAEEDHQPPLVRGRRVKLKYAHAGGYNPPIVVIHGNQVTDLSDSYKRYLMNYFRRSLKVMGTPIRIQFKEGENPFAGKRNPLTPNQMRKRKRLMSHLKKGK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: CSN8_MOUSE
Sequence: MPVAVMADNAFSFRKLLDQCENQELEAPGGIATPPVYGQLLALYLLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLEQGWQADSTTRMVLPRKPASGTLDVSLNRFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 8, SGN8, Signalosome subunit 8, COP9 homolog, JAB1-containing signalosome subunit 8.
What is the protein family that this protein belongs to?
Belongs to the CSN8 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GCH4_PSE14
Sequence: MNNPLPDVALTEVSSALVSLDWVGMQGVEVPVRLAEAGVRYPVHAHVDLQVDLADPSVKGIHMSRLYRLLDRYAEHQILSPDTLGALLEAMVESHLDCHSSRARLTLSFNLLCRRPALITEGLSGWKSYPVKLDATWHAGRLCLDVSADITYSSTCPCSAALSRQLLEGAFTARFGRQSFVDPMQVATWLRENASFATPHSQRSVATVQVRVAEQATELGLMTLIDAVEQALGTPVQTAVKRADEQAFARLNGQNLMYVEDAARKVQQALEGRYAASSVSVRHFESLHPHDAAAQTSNYLS
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: IPK_METJA
Sequence: MLTILKLGGSILSDKNVPYSIKWDNLERIAMEIKNALDYYKNQNKEIKLILVHGGGAFGHPVAKKYLKIEDGKKIFINMEKGFWEIQRAMRRFNNIIIDTLQSYDIPAVSIQPSSFVVFGDKLIFDTSAIKEMLKRNLVPVIHGDIVIDDKNGYRIISGDDIVPYLANELKADLILYATDVDGVLIDNKPIKRIDKNNIYKILNYLSGSNSIDVTGGMKYKIDMIRKNKCRGFVFNGNKANNIYKALLGEVEGTEIDFSE
What is the function of this protein?
Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.  Has no activity with farnesyl phosphate.
What are the official names of this protein?
Isopentenyl phosphate kinase, IPK.
What is the protein family that this protein belongs to?
Belongs to the isopentenyl phosphate kinase family.
Protein: RL29_STRPD
Sequence: MKLQEIKDFVKELRGLSQEELAKKENELKKELFDLRFQAAAGQLEKTARLDEVKKQIARVKTVQSEMK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: FLAV_RHOCB
Sequence: MAKIGLFFGSDTGTTRKIAKQIKDMFDDEVMAKPLNVNRADVADFMAYDFLILGTPTLGDGQLPGLSANAASESWEEFLPRIADQDFSGKTIALFGLGDQVTYPLEFVNALFFLHEFFSDRGAKLVGRWPAKGYGFEDSLAVVEGEFLGLALDQDNQAALTPERLKGWLSLIAADFGLVLPA
What is the function of this protein?
Low-potential electron donor to a number of redox enzymes.  NifF is the electron donor to nitrogenase.
What are the official names of this protein?
Flavodoxin.
What is the protein family that this protein belongs to?
Belongs to the flavodoxin family.
Protein: RS15_PSEA8
Sequence: MALSVEEKAQIVNEYKQAEGDTGSPEVQVALLSANINKLQDHFKANGKDHHSRRGLIRMVNQRRKLLDYLKGKDVSRYTALIGRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SYT_FRAT1
Sequence: MINIRFPDGSIREFEAGVNSLDVAKSISPSLAKATMAAYIDDQLKDAKDAINSNCELRLITVKDPEGLEILRHSCAHLLAHAVKELYPNTEVTIGPVVDNGFYYDFSFKESIGEADLPTIEKKMKELAKKSAPISYRVVPKAEAIEFFKAQGENYKVEIIDSIADEQMKIYTQDNFSDLCRGPHIPNTSVLKAFKLTKLAGAYWRGNSDNEMLTRIYGTCWATKEDLEQYLNMLEEAEKRDHRKIGKVLDLFHFQEDSPGIAFWHDNGVRIWRQVEDYMRASNNKYGCSEIRTPLIADFSLWQKSGHASKYAENMFATKSENRDFAIRPMNCPTCVQVYNTKLHSYRDLPIRMAEFGIVHRNEPSGSLHGLLRVRSFTQDDGHIFCTPEQVEEEVILMVQQCFEVYKDFGFNDFAVKIALRPENRIGDDETWDKSEQMLKNALDANNVSYELLPGEGAFYGPKIEFHLKDAIGRSWQCGTIQLDFSMPQRLGATYIDKNGEKQVPVMLHRAIVGSLERFIGMLIEHYAGNLPLWLAPVQVAVMGISNNQDDYCKEVFIMLEKNGIRAKLDLRNEKIGFKIREHTLLRVPYLVILGKNEQEQKIITIRKHSGEDLGQMSVDDFCAFLDKQIQAKE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.