PharMolix/UniProtQA huggingface dataset:
Protein: PFA3_ASPFU
Sequence: MMATLATSPPTSPTWPKRRPRAWALRCERYCCAAATYFPLAFVYSLTTWAVYVEASIGLKPSRSPWIGLPTSILGVLLYICLNASYTVAVFTDPGSPLTTGAGRHQYSALPVSELPEYTAYTVSSTGGSRYCKKCQCPKPDRAHHCSTCKRCVLKMDHHCPWLATCVGLYNYKAFLLFLIYTSLFCWVDFAVSATWIWTEVFNDAPYLETMLPVNVVLLAILGGIIGLVLTGFTAWHISLAVRGMTTIECLEKTRYVSPLRKALDRHRYEHILGNHRDGNRASPVADSFGHRLQDYGQQILDAHANAIPGVTRAEEGEERLSPAPEQPASHGVSDDQLTPAQQALTRSYAELERQREHDRYQDYLNEEDNGKLPHAFDLGWRRNLLHLFGNRPLLWLIPVCTTTGDGWRWEPSRKFLEAQEGLRLKREQDMANQQHYYRDLYSRNMNNGRAWLGPNAAAPTWNPHQPLDSFRDPERPATGVSMRTLAPMSPRPRPGDSDFEDDISETDPLNQQSVPANGAVNQLQKANEASSATTNRREDSSEWRDWD
What is the function of this protein?
Palmitoyltransferase specific for VAC8.  Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).
What are the official names of this protein?
Palmitoyltransferase pfa3, Protein fatty acyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: PLGRF_HUMAN
Sequence: MEPKARCSDSQRGGPCTNHEPPALEEGGRRHRRARAGSSSGALGLQLRPRVRPQRRAAAAAAAAAAAAAAATAASAAASAILGGRAAAAQPIGHPDALERAARANLRARRGDAWRGRGAPQRRAPAEARALGAASRALARRGAAPAAPLRGQPGPALPPPGPEAEPALPGGGQLAVAGPAAPEAPGLGLGGGLDPVRPRGGGRTRGHPRGAGPGVRRGGLLGRGNLPHIGGGHIPLGLVFLVQPAAGGRALLLDQPAVAG
What are the official names of this protein?
POLG alternative reading frame, POLGARF, ORF-Y.
What are the subcellular locations of this protein?
[POLG alternative reading frame]: Nucleus, nucleolus. SUBCELLULAR LOCATION: [POLGARF C-terminal fragment]: Secreted.
Protein: NU2C1_NICSY
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFDGSLIFPECILIFGLILLLMIDSTSDQKDIPWLYFISSTSLVMSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATMKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVLIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDSLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 A, chloroplastic, NAD(P)H dehydrogenase, subunit 2 A, NADH-plastoquinone oxidoreductase subunit 2 A.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: OTC_NEIMB
Sequence: MNLKNRHFLKLLDFTPEEITAYLDLAAELKAAKKAGREIQRMKGKNIALIFEKTSTRTRCAFEVAARDQGAGVTYLEPSASQIGHKESIKDTARVLGRMYDAIEYRGFGQEVVEELAKYAGVPVFNGLTNEFHPTQMLADALTMREHSGKPLNQTAFAYVGDARYNMGNSLLILGAKLGMDVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKNVDFIHTDVWVSMGEPKEVWQERIDLLKDYRVTPELMAASGNPQVKFMHCLPAFHNRETKVGEWIYETFGLNGVEVTEEIFESPASIVFDQAENRMHTIKAVMVAALGD
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JUND_RAT
Sequence: METPFYGEEALSGLAAGASSVAGAAGAPGGGGFAPPGRAFPGAPPTSSMLKKDALTLSLAEQGAAGLKPGSATAPSALRPDGAPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTSTQFLYPKVAASEEQEFAEGFVKALEDLHKQSQLGAATAATSGAPAPPAPADLAATPGATETPVYANLSSFAGGAGPPGGAATVAFAAEPVPFPPPPGALGPPPPPHPPRLAALKDEPQTVPDVPSFGDSPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY
What is the function of this protein?
Transcription factor binding AP-1 sites (By similarity).  Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (By similarity).
What are the official names of this protein?
Transcription factor JunD, Transcription factor AP-1 subunit JunD.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Jun subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MAP1_MYCCT
Sequence: MITIKNQEQIQKMKIAGQVLAKGLNLLKSMIKPGVNCLDLDKAFEEFIKQNGCESNFKNYQGFPKTICISINDQLIHGIPRDRVLLDGDVVSIDAGCMYEKWHADSAFTMVCGIAKNKKNDILIRVTEEALELAIAELKPGIRVGTIGSIIQNYVESFDFSVPRDYTGHGIGLALHEDPYIPNYGIPNTGIRLQEGMVICIEPMVQMGTYKTKIADDKWTVYSADHSITAHFEHTILITKDGCEVLTKTER
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).  Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Protein: ARFC_ARATH
Sequence: MGGLIDLNVMETEEDETQTQTPSSASGSVSPTSSSSASVSVVSSNSAGGGVCLELWHACAGPLISLPKRGSLVLYFPQGHLEQAPDFSAAIYGLPPHVFCRILDVKLHAETTTDEVYAQVSLLPESEDIERKVREGIIDVDGGEEDYEVLKRSNTPHMFCKTLTASDTSTHGGFSVPRRAAEDCFPPLDYSQPRPSQELLARDLHGLEWRFRHIYRGQPRRHLLTTGWSAFVNKKKLVSGDAVLFLRGDDGKLRLGVRRASQIEGTAALSAQYNQNMNHNNFSEVAHAISTHSVFSISYNPKASWSNFIIPAPKFLKVVDYPFCIGMRFKARVESEDASERRSPGIISGISDLDPIRWPGSKWRCLLVRWDDIVANGHQQRVSPWEIEPSGSISNSGSFVTTGPKRSRIGFSSGKPDIPVSEGIRATDFEESLRFQRVLQGQEIFPGFINTCSDGGAGARRGRFKGTEFGDSYGFHKVLQGQETVPAYSITDHRQQHGLSQRNIWCGPFQNFSTRILPPSVSSSPSSVLLTNSNSPNGRLEDHHGGSGRCRLFGFPLTDETTAVASATAVPCVEGNSMKGASAVQSNHHHSQGRDIYAMRDMLLDIAL
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).  Could act as transcriptional activator or repressor.  Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.  Involved in the establishment or elaboration of tissue patterning during gynoecial development.
What are the official names of this protein?
Auxin response factor 3, Protein ETTIN.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HLDE_PSEFS
Sequence: MKLSMPRFDQAPVLVVGDVMLDRYWHGGTSRISPEAPVPVVKVEQIEDRPGGAANVALNIAALGAPASLVGVTGDDEAAESLANSLRGAGVRALFQRIAHQPTIVKLRVMSRHQQLLRIDFEEPFATDALALNGQVDELLEGVKVLVLSDYGKGALKNHQELIQAAKAKGIPVLADPKGKDFSIYRGASLITPNLSEFEAIVGGCADEHDLVTKGAALMADLDLGALLVTRGEHGMTLLRPGHPAMHLPARAREVFDVTGAGDTVISTLAASIAAGEELPHAVALANLAAGIVVGKLGTAAISAPELRRAIQRSEGSERGVLTIEQLLLAIDDARAHNESIVFTNGCFDILHAGHVTYLEQARAQGDRLIVAVNDDASVSRLKGPGRPINSVDRRMAVLAGLGAVDWVISFPEATPENLLAQVKPDVLVKGGDYSVDQVVGADIVSAYGGKVKVLGLVENSSTTAIVEKIRNNE
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: COBQ_AGRRK
Sequence: MTKAIMLQGTGSDVGKTVLVAGLCRLFANRGVRVRPFKPQNMSNNAAVAEDGGEIGRAQWLQSLAARVPSSVHMNPVLLKPQSETGSQIIVQGKVWGHAKGRDYQALKPQLLGAVLESFATMRAGTDLVIVEGAGSPAEINLRQGDIANMGFATRANVPVVLVGDIDRGGVIASLVGTYHILPEEDRRMIRGYIINKFRGDVSLFGTGIEAIGGFTGWPCHGIVPWLKAAGRLPPEDSVVLERLARGSDGALKIAVPVLPRIANFDDFDPLRAEPDVDLVFVRAGERLPADAGLVILPGSKSTIGDLMDLRAQGWDRDITAHVRRGGRVIGICGGYQMLGRMVHDPLGIEGSVTETPGLGLLDVETEMAPEKTVRNSTALSTEYDAPLSGYEIHLGVTRGKDCDRPSTVIDGRPDGARSGDGLIMGTYLHGLFCSDAYRAKLLASFGLSGERMDYRASVETALDEIATELEAVLDPAWLDSLAG
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: Y2884_YERPB
Sequence: MAALDPTLLILLALAALGILSHNMTVTLAILILIAIRITPLNSFFPWVEKYGLTIGVLILTIGVMAPIASGKISASEVLHSFVQWKSILAIVVGVAVSWLGGRGVSLMTHQPSVVAGLLVGTVLGVALFKGVPVGPLIAAGLLSLVIGKS
What are the official names of this protein?
UPF0756 membrane protein YPTS_2884.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NU4LM_MUNVU
Sequence: MSLVYMNIMTAFMVSLAGLLMYRSHLMSSLLCLEGMMLSLFVLATLTILNSHFTLASMMPIILLVFGACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RNH2_EHRRW
Sequence: MPDFSIENEILKLKNNKECIIVGVDEVGYGSLAGPVVSAAVFFPNYNNETTQDINDSKKLTPKTRQKIYNKIITRVKWSIGFAHIFEIDEYNILNATHIAMKRALTGLNAHIDIDYVIIDGNKIPNIPWNAQAIIGGDTISTSIAAASIIAKVTRDRLMETLHIQYPQYNWNKNKGYGTKDHITSLYKYGKTIHHRNTFTPISKISYMFKNS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAL13_YEAST
Sequence: MTLTKQTCAKQACDCCRIRRVKCDGKRPCSSCLQNSLDCTYLQPSRKRGPKSIRLRSLKRIAEVQRESGPNTIATAPVIYKRVPKKLIDQCLRLYHDNLYVIWPLLSYDDLHKLLEEKYNDNYVYWFLTALSAATLSDLQTEIKSEEEVTFTGKQLSNLCISSCQQFDDLDNSNIFNIMTYYCLHRSFAQISNARTSYRLCCEAVGLITVAGLHREETYGSLTFEEQQLRRKLYYLLLMTERYYAIYLHCATSLDATIAPPQLELVTDPQLSMDSFLEMIRVFTVPGKCFFDALAADSTDASCTEESLKKIWNELHTTSSEIEPWSNGYIDISFSRHWIRILAWKLAYQMRGSNFSLNANNGQIPIEIARDMLIDTYLTPENLYDVHGPGVPVKTLEIATALVDIVGQYDHNMKLEAWNVLHDVCKFAFSLNHYNNDMLKRFSTKCQNALITLPISKPLQLDGYPKDNEDIDP
What is the function of this protein?
Regulates the coordinate transcription of structural MAL1S (maltase) and AGT1 (maltose permease) genes.
What are the official names of this protein?
Maltose fermentation regulatory protein MAL13.
What is the protein family that this protein belongs to?
Belongs to the MAL13 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RAP2B_RAT
Sequence: MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSACVIL
What is the function of this protein?
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.  Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1.  May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK.  May regulate membrane vesiculation in red blood cells (By similarity).
What are the official names of this protein?
Ras-related protein Rap-2b.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood cells-released vesicles.
Protein: CBID_PSEPK
Sequence: MREETREQPAPLRSGLTTGSCATATSLAAAKLLLTGQRNDAVDITLPKGKVVQMRLEFCRLIGECAEAGTLKDAGDDPDVTHGALVYSQVRLLVEPGIGFVAGSGVGTVTRPGLVLAVGEPAINPVPRRMISEHLQHLADACGYLGGFEVTVNVQGGEQLALKTMNPRLGILGGLSILGTSGIVRPFSCAAYIASIHQGIDVAHTNGYTHIAACTGNASEDTMRRVYGLPEIALIEMGDFVGAVLKHLRKVPVPRLTLCGGFGKISKLAAGHMDLHSRHSSIDLPQLAGWAADIGADEALQAAISGANTSQQALALAHAAGIALGDAVCAHALAFARSVVPAQVHVEVFAIDRQGGIVGQAGVQ
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: LEU3_ZYGBA
Sequence: MSKNIVVLPGDHVGQEIAQEAIKVLEAISEVSPKAKFNFQHHLIGGSAIDATGSPLPDEALAAAKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELQLYANLRPCNFASESLLELSPLKPQHARGTDFIVVRELVGGIYFGQRKEDDGDGVAWDSERYTKPEVQRITRMAAFLALQHNPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPQLTVKHQLIDSAAMILIKNPTQLNGIIITSNMFEDIISDEASVIPGSLGLLPSASLASLPDTNEAFGLYEPCHGSAPDLPKGKVNPVAMILSAAMMLKLSLNMAKEGEALETAVKQVLDSGVRTGDLGGSNSTSEVGDAIAKAVKQILA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, IMDH, Beta-IPM dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_SACD2
Sequence: MLDPKLLRNQLNDVAENLKKRGYELDTQAFTALEERRRTLQTACESLQQERNTRSKNIGKAKAAGEDIGPLLQEVDNLKSALAEAEQNLQALQGELEALVSAIPNMVHDDVPAGKSEDDNVEISKWGEPKTFDFEVQDHVDVGAAIGGLDFETATKITGARFSLMRGDIASMHRALTQLMLNTHIDEHKYEEVYVPYIVNKDSLYGTGQLPKFEEDLFKLTDDREFYLIPTAEVPVTNIARGEIFDESQLPVRFVAHTPCFRSEAGSYGRDTRGMIRQHQFEKVELVQLVKPEDSLNALEELTQHAEAILQKLGLPYRKVVLCGGDIGFSATKTYDLEVWIPSQGKYREISSCSCFGDFQARRMMARYRNSETNKPELLHTINGSGLAVGRTLVAVLENYQREDGSVEIPAALQPYMNGKTVIAKA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMC_AERHH
Sequence: MSQTSLHHARLDWNEAGTPVSSEFGDVYFSNDNGLSETRYVFLQQNRLPARFSHHDSDIFVIGETGFGTGLNFLATMAAFLEQAPQSGNGARLHFISFEKYPLTREDLRKALAAWPELATFSQPLIEQWPLPVAGCHRLLFAGGRIRLDLWFGDIKEMLPQVPHPADGLVDAWYLDGFSPAKNPEMWTQALFDGLARLARPHATIATFTCAGFVRRGLIAAGFAMQKVKGHGSKREMLAGERAEKQPQQTIAPWYARPAGRAGEVLIIGGGIASAMTALSLVERGRRVTLLCQDGEPATGASGNRQGALYPLLNGEHDVLSRFYSLAFGFARSRLLALAKRHPVAFSLCGVTQLGYDDKSAAKLAKMAQGPFPPELMQVLSEPEAEQVVGLPCGHGGVSYPQGGWLCPADLTRAAIKEAQASGLLEVVFNTEVVAMAEQADGWQVESRDGRRWQAPNLVVAAGHQLPALIPFAELPLYPVRGQVSHVPTSVSLSKLNTVLCYDGYLTPAHHDHHCIGASYGRNQTDLEFRADEQAQNQARLQACLPQQAWPAEVDVSGNQARVGVRSASRDHLPVVGPVASLAKLADHYAGLQGDQQNAAPLPLHPGLYVLGALGSRGLCSAPLCGELLASEICGDPLPLAADLLEALHPARYWVRKLLKGKPLQ
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMCO3_MOUSE
Sequence: MAQSDFLYPQNPRRRQEVNRLHQQLLDCLSDSFQVTNKLTGVLNTHLGCRLAFIEMKSDGTIKENCDIIIQAMTKIQKELQKIDEALKDQLEPTLYRKLQDIKERETEKIAIVQKVISVILGEATSAASAVAVKLVGSSVTTGIISKLVSVLAHIGTSLLGSIGVAVLSLGIDMIIQAILGAVERTQLQAAIKSYEKHLEEFKAASAKYHHAITEVATAVKRQLR
What are the official names of this protein?
Single-pass membrane and coiled-coil domain-containing protein 3.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GRPE_SHEB8
Sequence: MSNESIKAEQDLIQEGVESEVSTAEASLIDELTQANFRIEELEQLLAEALAKVEEQKDSVIRAAAEVDNIRRRAAMDVEKANKFALEKFANELLPVLDNMERALMGTNPEDEATKSIYQGVELTQKSLLTAVAKFGVKQIDPQGQSFNPDQHQAIGMQPSAEFPANTVMLVMQKGYELNSRLLRPAMVMVSQGGPNQESATIDIEA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FKB12_DROME
Sequence: MGVQVVPIAPGDGSTYPKNGQKVTVHYTGTLDDGTKFDSSRDRNKPFKFTIGKGEVIRGWDEGVAQLSVGQRAKLICSPDYAYGSRGHPGVIPPNSTLTFDVELLKVE
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  Binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor.  Binding is inhibitory to the signaling pathways of the TGF beta family ligands.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase Fkbp12, PPIase Fkbp12, 12 kDa FK506-binding protein, 12 kDa FKBP, Macrolide-binding protein, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYP22_ARATH
Sequence: MNSGGGIVAAAAPSSGGGNVEWHVRPPNPKNPVVFFDVSIGGIPAGRIKMELFADIAPKTAENFRQFCTGELRKAGKPLGYKECQFHRVIKDFMVQSGDFLKNDGSGCMSIYGHKFEDENFTAKHTGPGLLSMANSGPNTNGCQFFITCAKCDWLDNKHVVFGRVLGDGLLVMRKIENVAIGPNNRPKLAVVITECGEM
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase CYP22, PPIase CYP22, Cyclophilin of 22 kDa, Cyclophilin-22.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
Protein: ARP2_ORYSJ
Sequence: MDSGNVVVCDNGTGYVKCGFAGENFPTSVFPCVVGRPLLRYEESLQEQELTDIVVGAACADLRHQLDVSYPVTNGIVQSWDDMGHIWDHAFYSELKVDPSECKILLTDPPLNPVKNREKMIETMFEKYNFAGVFIQVQAVLSLYAQGLLTGLVIDSGDGVTHVVPVVDGFSYPHITKRMNVAGRHITSYLVDLLSRRGYAMNKSADFETVREIKEKLCYLSYDYKREYQLGLETTILVKSYTLPDGRVIKVGTERFQAPEALFTPELIDVEGDGMADMAFRCIQEMDIDNRMTLYQHIVLSGGSTMYPGLPSRLEKEMLDRYLDVVLKGNKDGLKKLRLRIEDPPRRKHMVYLGGAVLAGIMKDSPEFWITRQEYQEEGLACLRKCGQA
What is the function of this protein?
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the pointed end of the daughter actin filament.  Regulates the directionality of cell expansion by regulating the actin organization, and thus the microtubules distribution and the fusion of small vacuoles (By similarity).
What are the official names of this protein?
Actin-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: GLYA_MESHJ
Sequence: MYKKIKLRDQQISELINLESKRQNSQIELIASENYASEDVILANGTSPSNKYGEGYPGKRYYGGCTFIDQIEKIAIERVKKLFKIEYANVQPYSGSSANAAVFAALLKPGDKILGLDLNAGGHLSHGYKINFSGMFYSGISYFLDENELLDYDAIEKIALKTKPNLIICGYSAYSRKIDFARFRQIADKVNAFLLADIAHIAGLIAAGQHPSPVGYAHIITSTTQKTLRGPRGGLILTNSKEIAAKIDKVVFPGIQGGPFFHTIAAKAVAFKEALEPWFKEYCAQIVKNASHFASEFIKKGIRIVSQGTENHLFTIDVLSSYNLNGKQAQILLESVNIITNKNTIPNDTLSPFVTSGLRLGTPAMTSRGFKEQEFSQMAEIIDFVLRKKELNALEIKEIKKKVKILTKNFPIKKSYWP
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.
What are the official names of this protein?
Probable serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_UREP2
Sequence: MKVRASVKAICKDCKIVKRSGVVRVICANSKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LIPL_NEOVI
Sequence: MESKALLLVALGMWFQSLTATRGGVAAADRGGDFIDIESKFALRTPEDTAEDTCHLIPGVTESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGKDVAKFINWMAEEFHYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESDTQTNQAFEISLYGTVAESENIPFTLPEVSANKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIEKIRVKAGETQKKVIFCSREKVSHLQKGKASVVFVKCHDKSLNKKSG
What is the function of this protein?
Key enzyme in triglyceride metabolism.  Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:9852258).  Mediates margination of triglyceride-rich lipoprotein particles in capillaries.  Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).
What are the official names of this protein?
Lipoprotein lipase, LPL.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Secreted, extracellular space, extracellular matrix. Note=Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells. Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non- coated endocytic vesicles.