PharMolix/UniProtQA huggingface dataset:
Protein: FUCI_CLOPE
Sequence: MKTYPKIGIRPTIDGRQGGVRESLEEKAMKMAQAAKKLIENSLYYADGTPVQCVLASRTIGGSGDAGIVQQEFTGKNIVATLSVTPSWCYGTETMDLDPNTIKAIWGFNGTERPGAVYLAAAMSGYAQKGIPAFKIYGHDVQELDDDTIPVDVQEKILSFARGAIAVGQMKGKSYVNIGASSMGIAGSQVDISFFEDYLGMLVEFVDMTEILRRIHLEIFDPIEYDKALNWIKENCREGIDINEGKDLPDIVKKSKVIPADKDWEFIAKQAIIIRDILYRNEKLGDLGWEEEARGRNAIAGGFQGQRQWTDWLPNGDFTEAIMASTFDWNGPRQVTAFATENDTLNGVSMLLGTLLTNKAPIFSDVRTYWSPESVKRVTGKELTGKAKNGIIHLINSGASALDGTAAAKDKDGNKTMKEFWNMTNEDVQSCLKATDWCRANYEYFRGGGFSSHFKTEAELPVTLIRVNLIKGIGPTLQIAEGYTCVIDEDIHQILDERTDKTWPTTWFAPNLGECGFETVYDVMNHWGANHGAFVHGHIGSDLITLASMLRIPVTLHNVPRERIFRPNIFEGAGTKALETADFEICRLLGPLYKK
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOL4_ALTSO
Sequence: MPSTLIHDVQKELKDLPARGIVDFLIQYFFEDINWINQIVHPPRLLAQYENWWKMDTITRVADLEFAVLMLRICAYASHFLPSKKYTVDTIKGRPLSDIRSNCDRLAGRLEGICNAAVLRGSLVRVQYMAFTAMCYECDSRIKLSWDTLCCAIREAQEVGLHREPPMRGDDGMDDLEREMRRRMFCNLRLAKALDRVPFLVDAYCTVSLPQMHLHPTIANLQAPDLFTERVLQAQLVRFWKKLEAVNGPPGARPYDPVIAEERYQRFCNEFLPELPAPFALEPNTDWDQHIPELPRQRELFHVALFESVMHNFRQLLRLDQHHLRSLPNSRMALVTQHRHTLATAAMGLFQSVTSLHAMMSFNQTKLSLVIFYHFEMAVVLSLCIIRACDSNGMQDLEHINFFSPHSPLSSNMIDISQSQCLRTIKEARRQLEMMSLGSVMAETGARQLGILVDHVQATLARSGTQTRSMPSTETLTYNSSSSTSYGDGHAHGVSSELPFTFQQQEGPTANAFRTDSNVFEGLMLWDLSTDALPLDPSFLGLEQLHEISELQPNMGL
What is the function of this protein?
Probable transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of the phytotoxin solanapyrone, a causal agent of early blight disease of potato and tomato (PubMed:20486243).
What are the official names of this protein?
Probable transcription factor sol4, Solanapyrone biosynthesis protein 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPX_COXB1
Sequence: MSSDEKLQILYCSFCGKSQHQVRKLIAGPAVFVCNECVDLCNDIIREEEIAQAGGAQKKLPTPPEIHRMLDEYVIGQEFAKKVLSVAVYNHYKRLGNQTKKDSVEISKSNILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTEAGYVGEDVENIIQKLLQKCNYDVEKAKTGIIYIDEIDKIARKTDSPSLTRDVSGEGVQQALLKLIEGTVASIPPQGGRKHPQQEYLQVDTSNILFICGGAFADLHKIIQRRTDKSGIGFAAEVRPKEDFSREASKLIKQTEPGDLIKYGLIPEFVGRLPIITTLEELDEDALMRILTEPKNALVKQYRKLFEFEGVEIDFREDALKAIAKRAIQQKTGARGLRSIVEHTLLDLMYDLPGVAAGLRKVVIDSGVIDQASPPIFIYHHEKASRKVAQE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: MRE11_MOUSE
Sequence: MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEVISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGNTNFIPEQFLDDFIDLVIWGHEHECKIGPIKNEQQLFYVSQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMQKLPLRTVRRFFIEDVVLANHPNLFNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPGKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANPKDVIHFFRHREQKGKTGEEINFGMLITKPASEGATLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRNTNEEDDEVREAMSRARALRSQSETSTSAFSAEDLSFDTSEQTANDSDDSLSAVPSRGRGRGRGRRGARGQSSAPRGGSQRGRDTGLEITTRGRSSKATSSTSRNMSIIDAFRSTRQQPSRNVAPKNYSETIEVDDSDEDDIFPTNSRADQRWSGTTSSKRMSQSQTAKGVDFESDEDDDDDPFMSSSCPRRNRR
What is the function of this protein?
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis.  The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11.  RAD50 may be required to bind DNA ends and hold them in close proximity.  This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point.  The complex may also be required for DNA damage signaling via activation of the ATM kinase.  In telomeres the MRN complex may modulate t-loop formation.
What are the official names of this protein?
Double-strand break repair protein MRE11, Double-strand break repair protein MRE11A, MmMRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog A.
What is the protein family that this protein belongs to?
Belongs to the MRE11/RAD32 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere. Chromosome. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents.
Protein: GALK2_HUMAN
Sequence: MATESPATRRVQVAEHPRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGLKGIQEHFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAKYKSLQWDKVLRLEEVQAKLGISLEEMLLVTEDALHPEPYNPEEICRCLGISLEELRTQILSPNTQDVLIFKLYQRAKHVYSEAARVLQFKKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDGSLAPEKQSLFATKPGGGALVLLEA
What is the function of this protein?
Acts on GalNAc.  Also acts as a galactokinase when galactose is present at high concentrations.  May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.
What are the official names of this protein?
N-acetylgalactosamine kinase, GalNAc kinase, Galactokinase 2.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
Protein: BIPD_BURMA
Sequence: MNMHVDMGRALTVRDWPALEALAKTMPADAGARAMTDDDLRAAGVDRRVPEQKLGAAIDEFASLRLPDRIDGRFVDGRRANLTVFDDARVAVRGHARAQRNLLERLETELLGGTLDTAGDEGGIQPDPILQGLVDVIGQGKSDIDAYATIVEGLTKYFQSVADVMSKLQDYISAKDDKNMKIDGGKIKALIQQVIDHLPTMQLPKGADIARWRKELGDAVSISDSGVVTINPDKLIKMRDSLPPDGTVWDTARYQAWNTAFSGQKDNIQNDVQTLVEKYSHQNSNFDNLVKVLSGAISTLTDTAKSYLQI
What is the function of this protein?
Required for invasion of epithelial cells, as well as for survival within host cells, escape from endocytic vesicles and subsequent actin-tail formation.  Probably regulates the secretion of effectors BipB and BipC and their final integration into the target cell membrane (By similarity).
What are the official names of this protein?
Translocator protein BipD.
What is the protein family that this protein belongs to?
Belongs to the invasin protein D family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the bsa type III secretion system. Localizes to the tip of the external secretion needle that is part of the secretion apparatus (By similarity).
Protein: YAFD_SALPC
Sequence: MRKNTYAMRYVAGQPAERILPPGSFASIGQALPAGEPLSSEERIRILVWNIFKQQRAEWLSVLKNYGKDAHLVLLQEAQTTPELVQFATANYLAADQVPAFVLPQHPSGVMTLSAAHPVYCCPLREREPILRLAKSALVTVYPLPDTRLLMVVNVHAVNFSLGVDVYSKQLLPIGDQIAHHSGPVIMAGDFNTWSRPRMNALYRFAREMSLRQVRFTDDQRRRAFGRPLDFVFYRGLNVNEASVLVTRASDHNPLLVEFSPGKPEQ
What are the official names of this protein?
UPF0294 protein YafD.
What is the protein family that this protein belongs to?
Belongs to the UPF0294 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_ALIFM
Sequence: MQVTVETKEGLERVLTITVPAANIEDAVSAELRNIAKNRRFDGFRKGKVPMKMVAKMYGQAVRNDVMGEVMQRHFIEAIVKEKINPAGAPTFTPVEFAEGKDLVFSASFEVYPEVALQGLDKVVVEKPQVEVKDEDVAEMLETLRKQQSTWADADIAAEDGTRATINFVGSIDGEEFEGGKAENFPLEMGQGRMIPGFEDGIKGKKAGDELTIDVNFPEEYHAENLKGKAAQFAIKVVKVEARELPELNDEFVAKFGAEGGVEGLKAEVRKNMERELAQAVKNKIKEQAINGLVEQNNIDVPSALIDQEVQVLRQQAVQRFGGNADTAPELPRELFEEQAKRRVVVGLLLGEVIKSEELKADDEKVKALINEMASAYEDPTEVVAYYEGNEQMMNNMRNVALEEQAVEAILAKAQVSEKAFGFNELMNQQPA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PTGA_SHIFL
Sequence: MGLFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVGETPVIRIKK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II complex composed of PtsG and Crr is involved in glucose transport.
What are the official names of this protein?
PTS system glucose-specific EIIA component, EIIA-Glc, EIII-Glc, Glucose-specific phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACR_MYCTO
Sequence: MATTLPVQRHPRSLFPEFSELFAAFPSFAGLRPTFDTRLMRLEDEMKEGRYEVRAELPGVDPDKDVDIMVRDGQLTIKAERTEQKDFDGRSEFAYGSFVRTVSLPVGADEDDIKATYDKGILTVSVAVSEGKPTEKHIQIRSTN
What is the function of this protein?
Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase.
What are the official names of this protein?
Alpha-crystallin, Acr, 14 kDa antigen, 16 kDa antigen, HSP 16.3, Nox16.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted, cell wall.
Protein: RL4_SULIL
Sequence: MYLELVKKNSVILDKDGNKVKEVELPFIFSFPVRKDIIRRVFLAEFTHSLQPKGRDPMAGKRTSAESFGINLGMARVPRVKNSGEAALAPNTVGGRLTFPPSVDKKLVEEANDKEKQLAVISALSATADKVFVKARGHVFKDSVSFPIVVTDDIVSLKTASEVEEFLEKIGVYDDVKRVKERIRIRAGKGKMRGRKYKESIGPLIIVHDSNSPIVKAARNIAGVDVVNAKDVSVIHLAPGTHSGRLTIYTETSIKILDERLSKRLVS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PILA4_THET2
Sequence: MRNAKGFTLIELLIVIAIIAILAAVLIPNLLAARKRANDTVVTAYLNDAVKFQEMYQIDNNSYTSNQAALISLGLKSTPANVTFSIVSASANSYCMIAGHSGGTVWFAATPDKGVYKTNTAVTSSQPESCP
What is the function of this protein?
Plays an essential role in the assembly of two types of T4P pili: a wide and a narrow that participate in natural transformation and twitching motility (PubMed:32376942).  Major component of the wide pilus that is essential for natural transformation working as a DNA translocator structure that spans the inner and outer membranes (PubMed:12839734, PubMed:19396940, PubMed:32376942, PubMed:16857013).  In addition, participates in the assembly of the narrow pilus composed of the PilA5 subunit that is required for twitching motility (PubMed:32376942).
What are the official names of this protein?
Type IV wide pilus major component PilA4, Type IV major pilin PilA4.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Cell outer membrane; Single-pass membrane protein. Periplasm. Note=The single N-terminal transmembrane is initially involved in the correct localization to the inner membrane. Once the leader sequence cleaved, this region plays a role in multimerization and protein-protein interactions in the periplasm and the outer membrane.
Protein: RL21_PYRHO
Sequence: MVQKPHSFRRKTRKKLRKHPRRRGLPPLTRFLQEFEVGQKVHIVIEPSYHKGMPDPRFHGRTGTVVGKRGDAYIVEVPDGNKVKTLFIHPVHLRPQK
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: RL22_THET8
Sequence: MEAKAIARYVRISPRKVRLVVDLIRGKSLEEARNILRYTNKRGAYFVAKVLESAAANAVNNHDMLEDRLYVKAAYVDEGPALKRVLPRARGRADIIKKRTSHITVILGEKHGK
What is the function of this protein?
The globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome.  This extension seems to form part of the wall of the exit tunnel.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: GLK_XYLF2
Sequence: MNAPQAPVLVADIGGTNARFALANPTLTSAPLLNDSMREFAVIEFPSLGEAAQHYLHHIGIHTTKGVFAIAGHVDGDEARITNHPWVITRTRTATMLGFDTLHLINDFVAQAMAISVLGPQDVIQIGSAKWEQFPLSAATRNYGIIGPGTGLGVGGLMIRNGRCYPLETEGGHVSFPPSTPEEIRILEILSQQFGRVSNERLISGPGIVNIHRALSEIDGIDPGPLRPQDITMRAADGDIRATRTINLFCNIFGTITGDLVLIQGAWDGVFLTGGLVPKLLNSIQHSGFRQRFEHKGRFSAIMARIPSLAVIHPHPGLLGAAAYARDTEQVPQEIKA
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_LISIN
Sequence: MILVIDVGNTNCTVGVYKEQKLLRHWRMTTDRHRTSDELGMTVLNFFSYANLTPSDIQGIIISSVVPPIMHAMETMCVRYFNIRPLIVGPGIKTGLNLKVDNPREIGSDRIVNAVAASEEYGTPVIVVDFGTATTFCYIDEAGVYQGGAIAPGIMISTEALYNRAAKLPRVDIAESSQIIGKSTVASMQAGIFYGFIGQCEGIIAEMKKQSNTSPVVVATGGLARMITEKSSAVDILDPFLTLKGLELLYRRNKPTTEK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAA_AERHY
Sequence: MLVKLDTLVARYDELNRLKTQRALGLMSRYGQQVFQLLPVMLHFNHPLLPGYVAGDVPHGIWSFTANEAQQAFIQDLCQNANCQNGLTTHDKSIQGLYSMGSTSSIGQCCHSDLDIWVCHVAGLSQERLELLDLKCQQLSKWAEQRGVDLNFFLIPEDKFRQRNDAQMQGESCGSAQHLLLLDEFYRSAMLIAGKRLLWYLVPAEYDDRYDEYVNGLFAHGKLSQDDWLDLGGFDRIPAEEYFGSALWQLYKGIDSPYKAVLKSVLMEAYSHEYPNTRLLSVTSRDWFQHNEGMHYRLDNYCLMLDKVTNYLKSIGDMQRLDLVRRCFYLKVCDGLSHPKEDHSPAWRREQMTQLVAYWGWSPERLHHLDHRQEWKVEDVKVAHAELLEALMQSYRNLIQFARRNNISESINPEDIGILSRKLYAAFESLPGKVQRINLTIAPDLSEPDLSLVQVPHGRLNRAGWYLYKHSLEPADIIGRAPLEYNGYISKLVSWAYFNGLLTPQSRVHLFNQGSDLHIDNLHQFCRDLSGTFPVKYPRATNLALSRPCEIRQLSIFLNLETDPTSHWVGQVIEFDANAADVFSFGRNLECLVGSVDLVYRNSWSEIRTLHFQGDEAVVDALTTILGKMHQDAAAPEMIEVFCYSQHFRSLVRTRFQQLVAECIELRLARDKQQLVKTLALGKEKYGIFFERRGVSVKKLENAIDFYRHISHNKLDHLPLRLDKTHSQHLPGIVDSYASEGLVQFFFDTRDAGTNIYILDEANRVEIYQHFAGNKDELVQGVNRFYTSSHERFSDAGQFSNFNLPPYYEIVQVNGELEVIPYRSQGPLRDGAGQARELGSATG
What are the official names of this protein?
Adenylate cyclase, ATP pyrophosphate-lyase, Adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAMA_ECOLI
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFEDVRVLRDGDTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTIADIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAEIQQINIVGNHAFTTDELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYVTVNITEGDQYKLSGVEVSGNLAGHSAEIEQLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSMPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDAVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYAVGINGTKNDYQTYAELSVTNPYFTVDGVSLGGRLFYNDFQADDADLSDYTNKSYGTDVTLGFPINEYNSLRAGLGYVHNSLSNMQPQVAMWRYLYSMGEHPSTSDQDNSFKTDDFTFNYGWTYNKLDRGYFPTDGSRVNLTGKVTIPGSDNEYYKVTLDTATYVPIDDDHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYFPHQASNYDPDYDYECATQDGAKDLCKSDDAVGGNAMAVASLEFITPTPFISDKYANSVRTSFFWDMGTVWDTNWDSSQYSGYPDYSDPSNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
(Microbial infection) Acts as a receptor for CdiA-EC93, the contact-dependent growth inhibition (CDI) effector of E. coli strain EC93; antibodies against extracellular epitopes decrease CDI.  Its role in CDI is independent of the other Bam complex components (PubMed:18761695).  Is not the receptor for CdiA from E. coli strain 536 / UPEC, which does not have the same mode of toxicity as CdiA from strain EC93; the decreased expression of bamA101 in some experiments decreases the level of outer membrane proteins in general (PubMed:23469034, PubMed:23882017).  Susceptibility to CdiA-EC93 is dependent on E. coli BamA; replacing BamA with the gene from S. typhimurium LT2, E. cloacae ATCC 13047 or D. dadantii 3937 renders cells resistant to CdiA-EC93.  Cells with BamA from another bacteria no longer form CdiA-EC93-induced aggregates with EC93 cells.  A chimera in which E. cloacae extracellular loops 6 and 7 are replaced with loops 6 and 7 from E. coli is susceptible to CdiA-EC93 and to CdiA-CT from strain 536 / UPEC (PubMed:23882017).
What are the official names of this protein?
Outer membrane protein assembly factor BamA, Omp85.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: TSN3_MOUSE
Sequence: MGQCGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLFPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVFILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNSDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETAKSCNGSLANPSDLYAEGCEALVVKKLQEILMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGTYA
What is the function of this protein?
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.
What are the official names of this protein?
Tetraspanin-3, Tspan-3, OSP-associated protein 1, OAP-1, Tetraspanin TM4-A, Transmembrane 4 superfamily member 8.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: METJ_SHEON
Sequence: MTEWNGEYISPYAEHGKKNEQVKKITVSIPLKVLKVLTDERTRRQVNNLRHATNSELLCEAFLHAYTGQPLPDDADLSKECPDSIPAEAKRLMDEMGIEWEDME
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCHN_CHLL3
Sequence: MLQVPGDVQILKEDNVTHSFCGLASVGWMYQKIRDSFFLILGTHTCAHFLQNALGMMIFAKPRFGIALIEEGDLSKNEPTLDEVIAEIKADHNPSVIFLLSSCTPEVMKVDFKGLADHLSTQQTPVLFVPASGLVYNFTQAEDSVLHALVPYCPVAPAGEKSVVFLGSVNDATADDLRAEAEELGIKVGGFLPESRFDRMPAIGPDTILAPIQPYLSRVAVKLERERGSRTLHSLFPFGPDGTRVFWEDLAREFGIEVDLRDREKAAWEKISRQTAMLKGKKVFLTADTMMELPLGRFLRSAGAEVVECSSAYINKKFLAKELKALEGVRVVEQPNFHRQLEDIKRLRPDLVVTSLMTANPFVGHGFIVKWSMEFMLMPIHGWSGVITLANLFVSPLDRRSKLPAFDKAVWLEGVMPAAE
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
Protein: RN112_HUMAN
Sequence: MPRPALSVTSFCHRLGKRERKQSFMGNSGNSWSHTPFPKLELGLGPQPMAPRELPTCSICLERLRDPISLDCGHDFCIRCFSTHRLPGCEPPCCPECRKICKQKRGLRSLGEKMKLLPQRPLPPALQETCPVRAEPLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLNHLLQGLPGLESGEGGRPRGGEASLQGCRWGANGLARGIWMWSHPFLLGKEGKKVAVFLVDTGDAMSPELSRETRIKLCALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHPNKAGQGHVGNIFQRLSGRYPKVQELLQGKRARCCLLPAPGRRRMNQGHASPGDTDDDFRHLLGAYVSDVLSAAPQHAKSRCQGYWNEGRAVARGDRRLLTGQQLAQEIKNLSGWMGRTGPGFTSPDEMAAQLHDLRKVEAAKREFEEYVRQQDVATKRIFSALRVLPDTMRNLLSTQKDAILARHGVALLCKGRDQTLEALEAELQATAKAFMDSYTMRFCGHLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVGAGLAATVGCMEKEEDERLLEGDREPLLQEE
What is the function of this protein?
E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development.  During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:28684796).  Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage.  Exhibits GTPase and E3 ubiquitin-protein ligase activities.  Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity).
What are the official names of this protein?
RING finger protein 112, Brain finger protein, Zinc finger protein 179.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Nucleus, nuclear body. Nucleus, nucleoplasm. Endosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Postsynaptic density. Perikaryon. Cell projection, neuron projection. Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas.
Protein: HLP_RICRI
Sequence: MTITKAKIAAMLSSKLGFSNHLCEEIVHTVFSNILEIAKAQKLTLKNFGSFEVKQKNPRPGINFHTKALVIIESKKHLRFVPSSKLKALINESTR
What are the official names of this protein?
Histone-like DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: SSA1_MANHA
Sequence: MYKIKHSFNKTLIAISISSFLSIAYATESIENPQPIIQLSESLSSKYSGKGVKLGVMDEGFMVKHPRHSSHLHPLIHQLTTPEGEVRIYDASYPQFEVNPVEKEDGIDLIPSLETHGAGVAGIIAAQADKTLGDGYSGGIAKGAELYVATKSYKRTLEKVIQDAKKELENAKDEEDEKTPSLDQMAKNDLLASKEKEMAIERAEWASGLNKLLDNNVFAINNSWNPFSISDDINVVDKFYQSIKQNKHNPLLQAIMRAKNSNTLLVFAAGNESKKQPGVMALLPRYFPELEKNLISAVAVDKEQKIASYSNHCGASKNWCVAAPGDLHVLIGVADEHKKPQYGLTKEQGTSFSAPAITASLAVLKERFDYLTATQIRDTLLTTATDLGEKGVDNVYGWGLINLKKAVNGPTQFLNDETITVTRDDHWSNPLASQFKITKKGDKSLHLDGENHLDTVAVEEGRLALNGKTKVKTISNHANLAVNGTEVEQNYSSSGQSQLEVLGKSGLIANAQANIHLAGSLKIDDKLTEKTEAGDVSATVVQLKDKATYQGGFTQLVENENLAKRGLIQDLYFKESEIIAKVNKPLTDEKADTNGQAGLALLNALRTTPIAYRRSWYNGWLQSALEQRKLDNLHYAVSNNIYADSLELLRSQNRKGLTQAQQHLFTAYHTPLQTTVWAEHLNQKQSASSKHTDVKHHQSQLGVNHKLADKTVLSATLSQQKNRLEKPFAQATLKQTALNIGLRYHLDNAWFSEATLQFARQKYQQSRRFASHQLGTAETRGSTLGGEMRIGYQFMPNQWIIEPSLGVQWIQTKMNGLNESGELATQTAAMRYRDVNIVPSVKLQRTFQLEQGSISPYIGLNYLHRLNGKITKITSNIAGKTLHSEATTKRNRQLNGEVGVKLHYKNWFTAMNLDYSRVKSCKPIWLESKCWL
What are the official names of this protein?
Serotype-specific antigen 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: MTNB_MARN8
Sequence: MFDVTRYATAAQSIVEAGRFLYERGWSPATSSNYSARIDGDHVAITVSGRHKGQLGAGDVMVVDLHGQAVQSDCRSSAETLLHTVIYQLYPEVGAVLHTHSVKATVLSRLIPAGQALELEGYELQKAFNGVQTHEGKLIVPVFDNTQDIPALAEETRDWFARHPEQPGYLIRGHGLYTWGRTMADCLRHIEAFEFLFECELETMRVRR
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.