PharMolix/UniProtQA huggingface dataset:
Protein: PYRD_ECO8A
Sequence: MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RIMK_CHRSD
Sequence: MHIGILSRNRRLYSTRRLVEAAEARGHTARVVDTLRCYMNIASHRPSIHYKGEEIEPFDAIVPRIGASVTFYGCAVLRQFEMMSTYVLNDSVSITRSRDKLRSLQLLSRKGLGLPVTGFAHSPDDIPDLITMVKGAPLVIKLLEGTQGIGVVLAETNQAAESVIQAFMGMKANIMVQEYIKEAKGADVRCLVIGDKVVAAMKRQAAEGEFRSNLHRGGTASVIRITPEERSTAIRAAKAMGLRIAGVDLLRSNHGPVIMEVNSSPGLQGIETATGKDIAGQIIEYIEKNASTPRKAPPKPKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: CWC26_KLULA
Sequence: MSLNDFLAKSYGSKHGKEKTKKSKDKSSHRKSDESKRVTSRNIDIIDKANLITEENKKAASSNKTGKSLWKNLETEKLELVQHVDVDKKDDSKERMSSGAFAGLQTAEEMEKQIAEKEKLSMQKSGLLKKNQNTVYRDEKGKVIDGYEEELKLREKANLTAKVRKEEELKIRNIGEVQISKLDRKTEKSALLSTEDPLNQGNTLRGTNTSLLGRRLYEKNFPENRFGIVPGYRWDGVDRSNGFETKWFAKSHDIADQKIKEQTTNREF
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC26.
What is the protein family that this protein belongs to?
Belongs to the CWC26 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL5_BACC2
Sequence: MNRLKEKFQKEITPALVSKFNYKSVMEVPKIEKIVINTGVGDAVSNSKALDNAVEELTQIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGEQMYEFFDKLVSVSLPRVRDFRGVSKKSFDGRGNYTLGVKEQLIFPEIDYDKVSKVRGMDIVIVTTAKTDEEARELLTQFGMPFQK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: LUXS_PROMI
Sequence: MPLLDSFTVDHTRMSAPAVRVAKTMKTPSGDTITVFDLRFTVPNKKAMPEKGIHTLEHLFAGFMRNHLNGEGVEIIDISPMGCRTGFYMSLIGQPDEQRVANAWKAAMEDVLKVKDQNHIPELNVYQCGTYEMHSLAEAQDIARDILSHTIGINHNDELALPEDKLKELQI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: CDC5_YEAST
Sequence: MSLGPLKAINDKQLNTRSKLVHTPIKGNTADLVGKENHFKQTKRLDPNNDHHHQPAQKKKREKLSALCKTPPSLIKTRGKDYHRGHFLGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFRGTFPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEKSLLLESMSSDKIQRQKRDYISSIKSSIDKLEEYHQNRPFLPHSLSPGGTKQKYKEVVDIEAQRRLNDLAREARIRRAQQAVLRKELIATSTNVIKSEISLRILASECHLTLNGIVEAEAQYKMGGLPKSRLPKIKHPMIVTKWVDYSNKHGFSYQLSTEDIGVLFNNGTTVLRLADAEEFWYISYDDREGWVASHYLLSEKPRELSRHLEVVDFFAKYMKANLSRVSTFGREEYHKDDVFLRRYTRYKPFVMFELSDGTFQFNFKDHHKMAISDGGKLVTYISPSHESTTYPLVEVLKYGEIPGYPESNFREKLTLIKEGLKQKSTIVTVD
What is the function of this protein?
Protein kinase required for the cell cycle where it is involved in mitotic exit.  A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase.  Phosphorylates SCC1/MCD1 and NET1.
What are the official names of this protein?
Cell cycle serine/threonine-protein kinase CDC5/MSD2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Protein: CHLH_ARATH
Sequence: MASLVYSPFTLSTSKAEHLSSLTNSTKHSFLRKKHRSTKPAKSFFKVKSAVSGNGLFTQTNPEVRRIVPIKRDNVPTVKIVYVVLEAQYQSSLSEAVQSLNKTSRFASYEVVGYLVEELRDKNTYNNFCEDLKDANIFIGSLIFVEELAIKVKDAVEKERDRMDAVLVFPSMPEVMRLNKLGSFSMSQLGQSKSPFFQLFKRKKQGSAGFADSMLKLVRTLPKVLKYLPSDKAQDARLYILSLQFWLGGSPDNLQNFVKMISGSYVPALKGVKIEYSDPVLFLDTGIWHPLAPTMYDDVKEYWNWYDTRRDTNDSLKRKDATVVGLVLQRSHIVTGDDSHYVAVIMELEARGAKVVPIFAGGLDFSGPVEKYFVDPVSKQPIVNSAVSLTGFALVGGPARQDHPRAIEALKKLDVPYLVAVPLVFQTTEEWLNSTLGLHPIQVALQVALPELDGAMEPIVFAGRDPRTGKSHALHKRVEQLCIRAIRWGELKRKTKAEKKLAITVFSFPPDKGNVGTAAYLNVFASIFSVLRDLKRDGYNVEGLPENAETLIEEIIHDKEAQFSSPNLNVAYKMGVREYQDLTPYANALEENWGKPPGNLNSDGENLLVYGKAYGNVFIGVQPTFGYEGDPMRLLFSKSASPHHGFAAYYSYVEKIFKADAVLHFGTHGSLEFMPGKQVGMSDACFPDSLIGNIPNVYYYAANNPSEATIAKRRSYANTISYLTPPAENAGLYKGLKQLSELISSYQSLKDTGRGPQIVSSIISTAKQCNLDKDVDLPDEGLELSPKDRDSVVGKVYSKIMEIESRLLPCGLHVIGEPPSAMEAVATLVNIAALDRPEDEISALPSILAECVGREIEDVYRGSDKGILSDVELLKEITDASRGAVSAFVEKTTNSKGQVVDVSDKLTSLLGFGINEPWVEYLSNTKFYRANRDKLRTVFGFLGECLKLVVMDNELGSLMQALEGKYVEPGPGGDPIRNPKVLPTGKNIHALDPQAIPTTAAMASAKIVVERLVERQKLENEGKYPETIALVLWGTDNIKTYGESLGQVLWMIGVRPIADTFGRVNRVEPVSLEELGRPRIDVVVNCSGVFRDLFINQMNLLDRAIKMVAELDEPVEQNFVRKHALEQAEALGIDIREAATRVFSNASGSYSANISLAVENSSWNDEKQLQDMYLSRKSFAFDSDAPGAGMAEKKQVFEMALSTAEVTFQNLDSSEISLTDVSHYFDSDPTNLVQSLRKDKKKPSSYIADTTTANAQVRTLSETVRLDARTKLLNPKWYEGMMSSGYEGVREIEKRLSNTVGWSATSGQVDNWVYEEANSTFIQDEEMLNRLMNTNPNSFRKMLQTFLEANGRGYWDTSAENIEKLKELYSQVEDKIEGIDR
What is the function of this protein?
Multifunctional protein involved in chlorophyll synthesis, plastid-to-nucleus retrograde signaling and abscisic acid (ABA) perception.  In chlorophyll synthesis, catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.  The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP-dependent chelation step.  In addition to its function in the Mg-chelatase enzyme, is required for the plastid-to-nucleus retrograde signaling.  The plastid-to-nucleus signal plays an important role in the coordinated expression of both nuclear- and chloroplast-localized genes that encode photosynthesis-related proteins.  Has a role in mediating ABA signaling in stomatal guard cells and during seed germination.  Binds ABA and is a positive regulator of ABA signaling.
What are the official names of this protein?
Magnesium-chelatase subunit ChlH, chloroplastic, Mg-chelatase subunit H, ABA-binding protein, Mg-protoporphyrin IX chelatase subunit ChlH, Protein CONDITIONAL CHLORINA, Protein GENOMES UNCOUPLED 5, Protein RAPID TRANSPIRATION IN DETACHED LEAVES 1.
What is the protein family that this protein belongs to?
Belongs to the Mg-chelatase subunit H family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Plastid, chloroplast membrane; Peripheral membrane protein; Stromal side. Plastid, chloroplast membrane; Peripheral membrane protein; Cytoplasmic side. Note=Predominantly associated with the chloroplast envelope. Spans the chloroplast envelope and is its N- and C-termini are exposed to the cytosol (PubMed:20543028).
Protein: URED1_PSESM
Sequence: MNAHSSLLPICKKATAHIAFSKAPSGISYVSRQEVGYPFHLGRTLKLPQDPPGMAAIYLQSCSGGLFAGETLHLQLHAGPHTQVHVSTGAATVAHSMLEQPARQTVTLIAETGALLEYLPMATILFPQARLHSVVNVTLHPNARVMLCDAFCLHVPPGSAGLPGFYRADLHIRCPAGTLLAGDRLALTGADLQRRLPGVSAELQALATFMLVGQDLPVDELKRALRDALRVVPESYLGVSALPNDCGVSVRIMTADAVALRSALHLAWACARQQLTGIAPRVRRK
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD 1.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_DESPS
Sequence: MYRGLFLISEAVISRIEKKVLSGGKILFAEACDLALHCARADLDRLLALARQVGSLHHGKSIDLCSIVNARSGRCSEDCKFCAQSSHYSTGVDSYALVDPDYVLALAKQNEAYGVSRFSLVTAGRAVSPAFLREVASIYRRLGEETSLAPCASMGLLEPETAEMLVEMGVRRYHCNLETSASFFSEVCTSHTWQDKVATIEHARRAGLEVCSGGIIGLGESMEQRIELAFELRDLEVLSIPLNILNPIANTPFADLPALTEREILITFALFRLINPRAIVRTAGGRNLLAGQQKKLFLAGANGAIVGDYLTTSGDGLKKDIDMFLNLGFSIGSREK
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RNP1_THEAC
Sequence: MIYLDEFTGMEVSIVDSPNRSEIGRTGLVSFETKNTLEIDTGRKRIMIPKHLRKFRINGQFVDGDLINMRPEDRLREYRRILRDLRR
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 1, RNase P component 1, Rpp29.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEQA_TOLAT
Sequence: MKTIEVDDQIYRYIASRTLHIGESASDILRRLLALPLDTEPTVALGHEANAEQTDEVSTDVLTMLLDNAQLAKEESAIARFMLILSALYRSQPDAFRHAADIKGRKRIYFAEDPQALLDNGKTTKPKPVPETPYWVITNTNTGRKRLIIEQLMQAMGYSADLIAEVCNKV
What is the function of this protein?
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle.  Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins.  Repression is relieved when the region becomes fully methylated.
What are the official names of this protein?
Negative modulator of initiation of replication.
What is the protein family that this protein belongs to?
Belongs to the SeqA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAI14_MOUSE
Sequence: MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLKVMVTHGVDVTAQDSSGHSALHVAAKNGHPECIRKLLQYKSPAENIDNSGKTALHYAAAQGCLQAVQLLCEHKSPINLKDLDGNIPLLVAVQNGHSEACHFLLDHGADVNSRDKNGRTALMLACETGSSNTVDALIKKGADLSLVDSLGHNALHYSKLSENAGIQNLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEAPFKAEISSIQENKDRLSDSTAGADSLLDISSEADQQDLLVLLQAKVASLTLHNKELQDKLQAKSPKDKEAEADLSFQSFHSTQTDLAPSPGKASDIPSSDAKSSPPVEHPAGTSTTDNDVIIRQLQDSLHDLQKRLESSEAEKKQLQDELQSQRTDTLCLNNTEISENGSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLLSQESADGYSHLREAPADEDIDTLKQDLQKAVEESARNKERVRELETKLAEKEQAEATKPPAEACEELRSSYCSVIENMNKEKAFLFEKYQQAQEEIMKLKDTLKSQMPQEAPDDSGDMKEAMNRMIDELNKQVSELSQLYREAQAELEDYRKRKSLEDAAEYIHKAEHERLMHVSNLSRAKSEEALSEMKSQYSKVLNELTQLKQLVDAHKENSVSITEHLQVITTLRTTAKEMEEKISALTGHLANKEAEVAKLEKQLAEEKAAVSDAMVPKSSYEKLQASLESEVNALATKLKESVREREKAHSEVAQVRSEVSQARREKDNIQTLLKAKEQEVTALVQKFQRAQEELAGMRRCSETSSKLEEDKDEKINEMTREVLKLKEALNSLSQLSYSTSSSKRQSQQLDLLQQQVKQLQNQLAECKKHHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK
What is the function of this protein?
Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis.  Important for establishment of sperm polarity and normal spermatid adhesion.  May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.
What are the official names of this protein?
Ankycorbin, Ankyrin repeat and coiled-coil structure-containing protein, Novel retinal pigment epithelial cell protein, Retinoic acid-induced protein 14, p125.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cell cortex. Cell junction. Nucleus. Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites (PubMed:11168586). Highly expressed at the ectoplasmic specialization, an actin-rich cell junction specific to the testis (By similarity). Predominantly nuclear in nonconfluent cells (By similarity).
Protein: FABH_CLOBJ
Sequence: MSNISVIGTGSYVPNNIITNDFLSTIVDTSDEWIRTRTGILERRISKGENTIYMATESAKEAIKNANIEANDLDLIIVATLTPDNFMPSTACSVQKEIGAINALCFDISAACSGFIYGLEIACSMLKNSFRNKALIIGAENLSKIVDWEDRNTCVLFGDGAGAAILSKTKEEGILEFHSGSNGLKGEHLTCGVLKANNTPNKNDRLEKNNFIKMNGKEIFRFAVGAMNETICNIQEKTKWNLNEVKYIISHQANSRIIEYTAKKLNTEKDKFYMNLDKYGNTSAASIPIALDEMNKRGLLNKKDKIILVGFGGGLTFGGVAIVWSI
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLXA3_HUMAN
Sequence: MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNINKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPTLSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKCVQVRVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQELRALTRGHGATRTVRLQLLSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHTCTSRPHECSFQEGRVHSPEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHCPAPKTNWMHLSQKGTRCSHPRITQIHPLVGPKEGGTRVTIVGENLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEESLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYTQDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRLNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDSLRSRAPMITPDQETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHASDFSVLSALNELYFYVTKYRQEILTALDRDASCRKHKLRQKLEQIISLVSSDS
What is the function of this protein?
Coreceptor for SEMA3A and SEMA3F.  Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.  Plays a role in axon guidance in the developing nervous system.  Regulates the migration of sympathetic neurons, but not of neural crest precursors.  Required for normal dendrite spine morphology in pyramidal neurons.  May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system.  Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin.  The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
What are the official names of this protein?
Plexin-A3, Plexin-4, Semaphorin receptor SEX.
What is the protein family that this protein belongs to?
Belongs to the plexin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GLYA_XANOM
Sequence: MFSRDVRLETYDPELAKAIAAEAGRQEDHVELIASENYCSQLVMEAQGSQLTNKYAEGYPGKRYYGGCAFVDIAEQLAIDRIKQVFDADYANVQPHSGSQANQAVYLALLQPGDTILGMSLAHGGHLTHGAKANVSGKLFNAVQYGVNEQGLIDYDEVQRLATEHTPKMVVAGFSAYSQKIDWARFRAIADSVGAYLFVDMAHIAGLVAAGVYPSPMEHAHVVTSTTHKTLRGPRGGIIVAKGASEELQKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKTYQQQVVKNAQAMANTLIARGYKIVSGGTENHLMLVDMIGRDVSGKDAEAALGKAHITVNKNAVPNDPRSPFVTSGLRLGTPAITTRGYKEPDSIDLANWIADVLDAPTDEAVLAKVRDAVTAQCKRYPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_NITEU
Sequence: MAKIIGIDLGTTNSCVAVMEGNKPKVIENAEGARTTPSIVAYAEDNEILVGASAKRQAVTNPENTLFAIKRLIGRRFDEEVVQKDISVTPYKIVRADNNDAWIEARGRKIAPPEVSAQVLIKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKKEGDRKIAVYDLGGGTFDISIIEIAEVEGEHQFEVLATNGDTFLGGEDFDSRVIEYLVDEFRKESGIDLKKDMLALQRLKDAAEKAKIELSSSQQTEVNLPYITADASGPKHLAVKITRAKLESLVEELIERTAGPCRTALKDAGLSVSDINDVILVGGQTRMPKVQEKVKEIFGKEPRKDVNPDEAVAIGAAIQGGVLKGDVKDVLLLDVTPLSLGIETLGGVMTKLIQKNTTIPTKAQQVFSTADDNQTAVTIHVLQGEREVASGNKSLGQFNLTDIPSAPRGMPQIEVIFDIDANGILHVSAKDKATGKENKIKIQASSGLSEDEIQKMVKDAEAHAEEDKKALDLVNSRNQCDAMIHSVRKSLAEYGDKLEGDEKSRIEAALKEAEEALKSGDKQTIDAKTQALTEASHKLAEKMYAQEQAQAGQQAGAGTASDQSQDKPVEGEVVDAEFEEVKDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ATPE_CLOBJ
Sequence: MKDNIELTIFTPEKNIKIGEIKEVITEGLDGDLAILPNHVNMITYLKPTITKYIDLNGNKNNIFTSSGVLKVEDNKVYIICDASEKPEDIDIKRAENAKKRAEERLRNKKEIDVKRAELALFRSIARIKIKEL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS2_LACCB
Sequence: MAVLSMKQLLEAGVHFGHQTRRWNPKMKPYIFTERNGIYIIDLQKTVKMIDDAYNFVKEEAQNGGVFLFVGTKKQAQDAIAEEATRAGQYYVNHRWLGGTLTNWNTIQTRIKRLKDIKKMATDGTFDVLPKKEVSLLKKQQDKLEKFLGGIEDMPRIPDVLFIVDPRKEKIAVQEAQKLNIPIVAMVDTNTDPDDIDVIIPSNDDAIRAVRLITSKMADAIIEGNQGEDQDDAQEQQVAADKKADSMEDIVEAVEGDNKSAK
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: APAG_PSEPF
Sequence: MSDPRYQVDVSVVTHYLADQSQPEHERFAFAYTITVQNNGEQPARLMSRHWVITDGDGHVEEVRGAGVVGQQPLIGAGKSHTYSSGTVMTTKVGTMQGSYEMVADDGKHFDAIIKPFRLAVPGALH
What are the official names of this protein?
Protein ApaG.
Protein: SYT_PETMO
Sequence: MVKITYPDNSVQEFKDGITPAEIAKGISEGLYRNAIAAEINGELKDLNTPIMQDSTIKLITLDDEIAPKIYRHTMAHIMAQAVARIFGEDRVKLAIGPVIENGFYYDFDIEGHNLSEEDFSKIEEEMKKIIKEDIKIIRKEVNKKEAIELFKDQPYKLELIEELEEDTISVYFQGDFYDLCRGPHLPSTGYVKYFKLLSVSGAYWRGDEKNKMLQRIYGTAFPKKEQLDDYLNMIEEAKRRDHRKLGPKLNLFMLQSEMAPGMPFFLPNGKIVLNELMAYSRQVHKKYGYVEVETPQIMNIKLWHQSGHWDHYKENMFFTEKEDMPMAVKPMNCPGHILIYKNNFVSYRDLPIRMFEFGKVHRYERSGVLHGLFRVRAFTQDDAHIFCMPSQMEEEIIKVIQLTNEIFSTFGFKYEAILSTMPEDHMGDIESWERATDALKKALEKSNMEYRIDEGEGAFYGPKIDFNVTDSLGRKWQCTTIQLDFQMPERFDMVYADENDAQKRPVMIHRAIFGSLERFFGILIENFAGEFPTWLSPVQVSILPVSEKFNEEAKKFSRILEQEGIRVYVNDSDATVGYKIRNEQMKKVPYMIVFGEKEMNSDTINIRTRKGDTIENVSKERFIEEIKNEIKNRNLDLTF
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAV3_MOUSE
Sequence: MEPWKQCAQWLIHSKVLPPNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRPHSINLKEINLRPQMSQFLCLKNIRTFLAACCDTFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETRVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAQQPKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDQNLYQVFINYKERLVIYGQYCSGVESAISNLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTHDPMEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFKCGAKAHKECLGRVDNCGRVNSVEQGPFKPPEKRTNGLRRASRQVDPGLPKMQVIRNYTGTPAPGLHEGPPLHIQAGDTVELLRGDAHSVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYAGPMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEQPAGQRGNRTGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDMVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
What is the function of this protein?
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1.  Binds physically to the nucleotide-free states of those GTPases (By similarity).  Plays an important role in angiogenesis.  Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.  May be important for integrin-mediated signaling, at least in some cell types.  In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function.  This signaling pathway involves RAC1, but not RHO, activation.  Necessary for proper wound healing.  In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils.  Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion.  Does not affect integrin beta-1-mediated adhesion.
What are the official names of this protein?
Guanine nucleotide exchange factor VAV3, VAV-3.