PharMolix/UniProtQA huggingface dataset:
Protein: KTHY_THEGJ
Sequence: MGIFVVIEGIDGAGKSTQAKLLAKWFEKKGYEVILTKEPTDTAFGKLIRKLVLTGGREGIIDGARISHEAEALLFAADRAEHVHKLIKPALESGKVVISDRYFYSSLAYQWARGLDLQWLIDLNRFAVRPDLVVLLDLPVKESMRRINGRSIKTEFDKIVELQKRVRENYLKLAEMFPEIRIVNAQNSIEDIHRDIVGLVEQEILSGI
What are the official names of this protein?
Probable thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SYC_PROMM
Sequence: MSLRLTNTLTRRTEPFTPLKDGHVSIYCCGVTVYDLCHLGHARSYIAWDVLRRYLIWRGYTVTFVQNFTDIDDKILKRAAEKECSMQEISEQNIEAFHQDMDSLGILRPDRMPRATQCLDGIRSLIGELEASGAAYSVDGDVYFAVMKHHGYGKLSGRDLNEQQQNADGRVADAEEARKQHSFDFALWKGAKSGEPSFPSPWGAGRPGWHIECSAMVREELGETIDIHLGGADLIFPHHENEIAQSEAATGKQLARYWLHNGMVNVGGQKMSKSLGNFTTIRALLENGVSPMTLRLFILQAHYRKPLDFTADAINAAATGWKGLNAALGLGNIYSETLNWPECKPLPQGVIQAAHPSNQEQCNKIRQHFIDALDDDLNSSGAIAVLFDLARPLRALANRLKRGDTKAIQETAKLNLLPRWQLLVELANVLGLEAEKAAQPAPERNNRVDENHIQRAIATRKEAKAARDFAKADLIRDELRAQGIELIDKPGGLTDWISS
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXH_SHIDS
Sequence: MATLFIADLHLCVEEPAITAGFLRFLAGEARNADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESDMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHNPWLQTLFLALPLFVRKRIAARMRANSKEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PNP_ECOSM
Sequence: MLNPIVRKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGQKKAKPGQDFFPLTVNYQERTYAAGRIPGSFFRREGRPSEGETLIARLIDRPIRPLFPEGFVNEVQVIATVVSVNPQVNPDIVAMIGASAALSLSGIPFNGPIGAARVGYINDQYVLNPTQDELKESKLDLVVAGTEAAVLMVESEAELLSEDQMLGAVVFGHEQQQVVIQNINELVKEAGKPRWDWQPEPVNEALNARVAALAEARLSDAYRITDKQERYAQVDVIKSETIATLLAEDETLDENELGEILHAIEKNVVRSRVLAGEPRIDGREKDMIRGLDVRTGVLPRTHGSALFTRGETQALVTATLGTARDAQVLDELMGERTDTFLFHYNFPPYSVGETGMVGSPKRREIGHGRLAKRGVLAVMPDMDKFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAGIAMGLVKEGDNYVVLSDILGDEDHLGDMDFKVAGSRDGISALQMDIKIEGITKEIMQVALNQAKGARLHILGVMEQAINAPRGDISEFAPRIHTIKINPDKIKDVIGKGGSVIRALTEETGTTIEIEDDGTVKIAATDGEKAKHAIRRIEEITAEIEVGRVYNGKVTRIVDFGAFVAIGGGKEGLVHISQIADKRVEKVTDYLQMGQEVPVKVLEVDRQGRIRLSIKEATEQSQPAAAPEAPAAEQGE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_SHELP
Sequence: MKFELDTTDGRARRGRLVFERGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFMDAEKSMQIQYSLGSDVVMIFDECTPYPATHDEARKSMQMSLRWAQRSRDEFDRLENPNSLFGIIQGSVYEDLRDESLKGLLEIGYDGYAVGGLAVGEPKEDMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFTSEGVIKIRNARHRDDTSPLDAKCDCYTCKNYSRAYLYHLDRCNEILGARLNTIHNLRYYQMLMEGLRGAIETGTLDAFVEEFYTSQGREVPKLSD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: HIS2_STRAW
Sequence: MSKKTFEELFTELQHKAANGDPSTSRTAELVGKGVHAIGKKVVEEAAEVWMAAEYEGKDAAAEEISQLLYHVQVMMVARGISLDDVYAHL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSM12_DROME
Sequence: MAAAAASAVNAVNDCFSIGSTVVCTTCFNEEVEGEVLAFDHNTKMLILKCRSKSTEELSDIYAMNLSLCSNVQVIKECNGNFDDPQKLNLEQVKMRLRKTVERRQDYLKSKNADVSPEAQELYRAIAKQYGYNEVSWQGLNIQILNEVTISPPYRVDNVVSSSNNETSCNYIKRIIKQFFNTRPSPVPESGAAASTSSPSVSPTSSSLASGSPVPAN
What is the function of this protein?
Component of the Atx2-tyf activator complex which functions in the circadian pacemaker neurons to activate the TYF-dependent translation of per and maintain 24 hour periodicity in circadian behaviors.  Within the Atx2-tyf complex, likely to function as a molecular adapter which stabilizes the interaction between Atx2 and the translational regulator tyf.
What are the official names of this protein?
LSM12 homolog A.
What is the protein family that this protein belongs to?
Belongs to the LSM12 family.
Protein: DSBC_ECOLI
Sequence: MKKGFMLFTLLAAFSGFAQADDAAIQQTLAKMGIKSSDIQPAPVAGMKTVLTNSGVLYITDDGKHIIQGPMYDVSGTAPVNVTNKMLLKQLNALEKEMIVYKAPQEKHVITVFTDITCGYCHKLHEQMADYNALGITVRYLAFPRQGLDSDAEKEMKAIWCAKDKNKAFDDVMAGKSVAPASCDVDIADHYALGVQLGVSGTPAVVLSNGTLVPGYQPPKEMKEFLDEHQKMTSGK
What is the function of this protein?
Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds.  DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins.  Acts by transferring its disulfide bond to other proteins and is reduced in the process.  DsbC is reoxidized by DsbD.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbC.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbC subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS7_RALPJ
Sequence: MPRRREVPKREILPDPKFGNVEVAKFMNVLMLDGKKSVAERIVYGAFDQIEKKAGKAPIEVFTLAIGNIKPVVEVKSRRVGGANYQVPVEVRPSRRLALAMRWLREAAKKRSEKSMALRLAGELLEASEGRGGAMKKRDEVHRMAEANKAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: PYRC_THEVO
Sequence: MDRAFCGNFYYNGKFDYLEVTVKDGVIESIKKDAGNIARSYLPGAVLPAATDIHVHFRTPGETDKEDFSTGSLSAIFGGTTLVMDMPNNIIPIKDYNAFSDKLGVINGTSYSDFALYSMETGSNSLIVDSRSIGLKVYLGGSTNAAGTMAIPDQEAEMINEKGFTVIFHGELEECLRKHQSETKNLREHNLSRPIECELAAAGYVGSLNLKSKIMAHVSSPEVSGDFLREVTPHHLLLNDEMPLGSIGKVNPPLRDRNTQERLLYAYISGQFDILSSDHAPHTEKDKAEFEYAKSGIIGVETRIPLMLALVKKKILFLDVLYKTGIERPPSIFGIRKGKIEVGYDADFMCVDFTNEKKVNEDRLHSKLPRSPFNGMDAIFPSHVVMRGEVVIDNYEEISDPLGRFVPKGYYDQKL
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: RL17_THEYD
Sequence: MRHRVSGRHFGRTANQRKALLRGLLASLIKYERIETTVAKAKAVKELADRLVTFGKKGDLHSRRIALSYLPDRELVKKLFNEIAPRFSDRNGGYVRVIKTGFRIKDSAPKAILEFVDYAKPEKESDKEEKKAN
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: MRT4_HUMAN
Sequence: MPKSKRDKKVSLTKTAKKGLELKQNLIEELRKCVDTYKYLFIFSVANMRNSKLKDIRNAWKHSRMFFGKNKVMMVALGRSPSDEYKDNLHQVSKRLRGEVGLLFTNRTKEEVNEWFTKYTEMDYARAGNKAAFTVSLDPGPLEQFPHSMEPQLRQLGLPTALKRGVVTLLSDYEVCKEGDVLTPEQARVLKLFGYEMAEFKVTIKYMWDSQSGRFQQMGDDLPESASESTEESDSEDDD
What is the function of this protein?
Component of the ribosome assembly machinery.  Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
What are the official names of this protein?
mRNA turnover protein 4 homolog, Ribosome assembly factor MRTO4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: DXS2_RHORT
Sequence: MTSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTVALHHVFDTPDDRIIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAGHSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAYEAMNNAGAAKSRLIVILNDNDMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGGGTLFEEMGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDKYHGVSRFNVVTGVQEKAKPQAPSYTAVFGKQLVAAAAKDHRIVAVTAAMPGGTGLDKLAAAYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQRGYDQVVHDVVLQKLPVRFAIDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYPRGEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVADARFLKPFDEELVADLAARHEVLIVVEEGAIGGFCSHVATWLANQGLLDGGLKLRALHIPDRFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDAGALKA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase 2, 1-deoxyxylulose-5-phosphate synthase 2, DXP synthase 2, DXPS 2.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: P8_WTV
Sequence: MSRQNWVETSALVECISEYIVRSYGDTFIGLTSTDLSTLSNLLSNLSIANVGFLNDLRTPLQNMSNEFVDFLSTTDRCGFMLRPIWFDSDINPAVTDNFVNSYIKLRNSVPVSDVIRQVNNLSLHNDVVLKIYSVQNAIIRALDPPYGTKVDPTNLFRATALKPSNYGQRRSLCTQLGAGVEAVDFFVSERGRMVFGRRSPNALQAAQYDINVPNFWSVLDVTNARVYFTNTFLGCTITNVQVNAQNGQNPVAFIRVNTDQNDINVDSDAIVSFSLAGGVINVTTAVPMTGFAIAIEGDFHFQMNRCQSYYTGVSITLGAQVPIDDFGIMKHLEIFRMRLLACGQAEMFAESMNRLTMQLIANYTQDNFNPNAVAFATPWYRISERFGVILSFIDQNINLQTRRLMVRHLWVIYSFIAVFGRYYNIN
What is the function of this protein?
Capsid protein which self-assembles to form the outer icosahedral capsid with a T=13 symmetry, about 70 nm in diameter and consisting of 780 molecules capsid proteins.
What are the official names of this protein?
Outer capsid protein P8, Structural protein P8.
What is the protein family that this protein belongs to?
Belongs to the phytoreovirus outer capsid protein P8 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Found in the peripheral regions of spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RL44_SCHPO
Sequence: MVNIPKTRKTYCPGKNCRKHTVHRVTQYKKGPDSKLAQGKRRYDRKQSGFGGQTKPVFHKKAKVTKKVVLRLECVSCKYKNQLVLKRCKHFELGGEKKTKGAAIQF
What are the official names of this protein?
60S ribosomal protein L42.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL42 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIM3C_HUMAN
Sequence: MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLIIPQGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHMSLHGH
What is the function of this protein?
Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development.
What are the official names of this protein?
RIMS-binding protein 3C, RIM-BP3.C, RIMS-binding protein 3.3, RIM-BP3.3.
What is the protein family that this protein belongs to?
Belongs to the RIMBP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: KDPC_BACC3
Sequence: MAKKQSILSPIIRITFTFLVLCGLVYPLIVTGIAQAVMKDNADGSLIYNDKNEVIGSKLIGQNFTDPRYFHGRVSSIEYKAEASGSNNYAPSNPDLEKRVEKSIEEWKKQNPSVPVTEVPIDLVTNSGSGLDPDISPKAASVQVERISKLTKIPKETLEQLIKDQTEGAALGLFGETRVNVLKLNLELQKLMKQ
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: KAD_YERPG
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGLKAKEIMDAGKLVTDELVIALVKERITQEDCRDGFLLDGFPRTIPQADAMKEAGIKVDYVLEFDVPDELIVERIVGRRVHAASGRVYHVKFNPPKVEDKDDVTGEELTIRKDDQEATVRKRLIEYHQQTAPLVSYYHKEADAGNTQYFKLDGTRNVAEVSAELATILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRS1_COCIM
Sequence: MAGKRKARDEEFIFTLSDEETPYINGGDFDEEDDDVAPSINKSKNTKTLKSRVEPSSKKRRNEESTTGHQNKKLKQQEQGQQKGLKGKRAIANGWDAENDSNGSGEDEEEEEDEEGEEGLLDSDFEFDIGGATNIGLVEEFDGWGAEDRDKQGNMGEAKKGVDLDEILCRRRQKKLESQEKKTREAAKSNVDDSFEGLSDDDGHNEDENEDNEMPNFDDDELLAPDAFGMGAEGESDEQGKANADKGSDDESMPDANGADEEDASDSDSVASPVAHPDDLRSDESSDSEEEDPEEVAKRNAFFAPEENPTKSEETSSNSTFQNFNLSRPILRGLAAVGFSAPTPIQRKAIPVGLLGKDLVGGAVTGSGKTAAFIIPILERLLYRPRKVPTSRVAILMPTRELAVQCYNVATKLATYTDITFCQLVGGFSLREQENVLKQRPDVIIATPGRFIDHMRNSASFTVDTLEILVLDEADRMLEDGFADELNEILNTIPKSRQTMLFSATMTDSVDKLIRVGLNRPVRLMVDSKKHTVGTLVQEFVRLRPGREGKRMGYLVLLCNTIYTNRVIVFFRQKKEAHRARIIFGLLGLKAAELHGSMSQEQRINAVEAFRDGKVPFLLATDLASRGLDIKGVESVINYEAPQSHEIYLHRVGRTARAGRSGRACTIAAEPDRKVVKAAVKAGRAQGAKIVSRVVDPAVADEWASKVEEMQAEIEDILKEEKEEKQLAQAEMQVKRGQNLIKHGSEIMARPKRTWFETEREKREAKKRALSELNGPDSVIKKEKRKLSGKEKKKLDDNRLREEGKIWKKGKKERESKGDMRSQGKGKAKKDKVKAKKAAR
What is the function of this protein?
ATP-binding RNA helicase involved in ribosome assembly.
What are the official names of this protein?
ATP-dependent RNA helicase DRS1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TOK_DROME
Sequence: MRRRRGTPLGVSWTNCVLLLATGLLVVLISVHAKNPRPHRGLPAPAPAPVPASVDQVATENAHRREPTVDGSVLQRLSGSDRAVDEDEDVDEDEDEGLKHQHLEHRQQFDAYLGTIRRLRRPYRSKYTIEQLMRLHVTPKVSGDIDMDPCKAGGFMGDIALPEGDSGPVVAHTPIDDEEQERQEVEQLLADSPSPVHDPPSVSGAANSGPTKFNATFQLDLEKLKQEVYHEGLQVEEEGLTDIIRKKTKLPSSGPVNLKAGQSQSQSQSANEPVKPGSESPSDYAQASSYKNEVLPPSEQRIHTDKPARLTLAEIGPKFSNKTQSLHRNVDTRKIQSDNKDIEDDSGNNFVAERRPSQIVPTSLPEQRSTPAHVYSNAGGNGMQLDDEVDFLHSRGVVRRRHRRGPKQRRSNQHLEHEVKLQRLREELSRPVIEAHHHQSHHQKQAQHRQHHQSHHRKKHRRQQQHHRRRGQSTTQYVNHSPPGFNQSQQAQQQSVPEMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVAVPNSGEYDHSDEDVENSYSSEMVTPFPGSLKSIYIEDTQEETDEYSDFSGNQLVFNGQYRGRYSLPKRYYSGKA
What is the function of this protein?
Metalloprotease which is required for cleavage of sli into slit N-product and slit C-product, ensuring correct slit N-product-mediated longitudinal axon guidance (PubMed:32994163).  Also cleaves TGF-beta family ligands daw, Actbeta and myo and is required for normal guidance of motor axons to their muscle targets (PubMed:17119021).  Cleavage of daw enhances its signaling activity (PubMed:17119021).  Required during mid- to late-embryonic stages for defasciculation of motor axons (PubMed:16971470, PubMed:17119021).  During pupal development, cleaves dorsal-ventral patterning protein sog which contributes to specification of the posterior crossvein in the wing (PubMed:15872004).  Processes sog less efficiently than metalloprotease tld which also cleaves sog (PubMed:15872004).  Promotes BMP signal transduction in the caudal visceral mesoderm, resulting in the translocation of Mad to the nucleus to promote stg transcription which allows for cell cycle progression and promotion of levels of cell death protein hid (PubMed:35709766).  This leads to elimination of cells that lose access to substrate-derived FGF during migration (PubMed:35709766).
What are the official names of this protein?
Protein tolkin, Tolloid-related protein, Tolloid-related protein 1.
Protein: CLIC6_MOUSE
Sequence: MAEATEPKEVAPGSQGQPEGATIEGPGEPGAADLEGREASEEAAEAPRDLGAGVEARASGKEEGGCGQDEGTGGAQAQDPRTGPEAETPGASGAPGEAEAAERDPEGAIPQGAEEAPSAQQVQGMSSGLDSQGEAPEVPGDSRREPEDPTASEAGEEAESGQEAQGGGALGLQINPEVQGLAGDNMDTEAPAGGPLGSESEPQGGGESSPQPQDEAIEIVTTEIGGNESGELAGASAADAAGEGETLGKDGSEEAASEDARVDAHENGDQGKLQEETGEEEARPEPELKGPCEGAIQEKPPDGSLDGEEAKSTEHEEESQAELSNHLAEEPSVQGGEELGRVNGRRENGPALEEGDPGQEHDITLFVKAGYDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLVPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIYEKNLLRALKKLDSYLNSPLPDEIDADSSEDVTVSQRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADREIEHAYSDAAKRMK
What is the function of this protein?
May insert into membranes and form chloride ion channels.  May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).
What are the official names of this protein?
Chloride intracellular channel protein 6.
What is the protein family that this protein belongs to?
Belongs to the chloride channel CLIC family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity).
Protein: Y799_TREPA
Sequence: MKTGFWQQVLPKRAGRRKEHPVQYMPHKKEENATGLMNPSLHTSHSAILK
What are the official names of this protein?
Uncharacterized protein TP_0799.
Protein: IF23B_XENLA
Sequence: MNKLYIGNLSENVSPPDLESLFKESKIPFTGQFLVKSGYAFVDCPDETWAMKAIDTLSGKVELHGKVIEVEHSVPKRQRSRKLQIRNIPPHLQWEVLDSLLAQYGTVENCEQVNTDSETAVVNVTYANKEHARQGLEKLNGYQLENYSLKVTYIPDEMATPQSPSQQLQQPQQQHPQGRRGFGQRGPARQGSPGAAARPKPQSEVPLRMLVPTQFVGAIIGKEGATIRNITKQTQSKIDIHRKENAGAAEKPITIHSTPEGCSAACKIIMEIMQKEAQDTKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGSIETCAKAEEEVMKKIRESYENDIAAMNLQAHLIPGLNLNALGLFPPSSSGMPPPSAGVSSPTTSASYPPFGQQPESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPAEGPDAKLRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLEAHIKVPSYAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHFYASQLAQRKIQEILAQVRRQQQQQQKTAQSGQPQPRRK
What is the function of this protein?
RNA-binding protein that acts as a regulator of mRNA transport and localization.  Binds to the RNA sequence motif 5'-UUCAC-3'.  Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity).  Mediates the specific association of Vg1 RNA to microtubules.  May regulate mRNA translation (By similarity).  Binds specifically to the vegetal localization elements (VLE or VgLE) in the 3'-UTR of Vg1 and VegT mRNAs.  Binds to the Vg1 and VegT mRNAs in both the nucleus and the cytoplasm.  May regulate mRNA translation (By similarity).  Acts as a transcription regulator (PubMed:1577195, PubMed:12957389).  Binds to the 5'-[TA]GGTTACT-3' motif within element 3 of the TFIIIA gene promoter (PubMed:1577195, PubMed:12957389).
What are the official names of this protein?
Insulin-like growth factor 2 mRNA-binding protein 3-B, IGF2 mRNA-binding protein 3-B, IMP-3-B, 69 kDa RNA-binding protein B, B3.65 protein B, IGF-II mRNA-binding protein 3-B, KH domain-containing transcription factor B3-B, RNA-binding protein Vera-B, Trans-acting factor B3-B, VICKZ family member 3-B, VLE-binding protein B, Vg1 RNA-binding protein B, Vg1 RBP-B, Vg1 localization element binding protein B, VgLE-binding and ER association protein B.
What is the protein family that this protein belongs to?
Belongs to the RRM IMP/VICKZ family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Accumulates along the vegetal cortex in oocytes as oogenesis progresses ('late pathway' for RNA localization). Colocalizes with Vg1 RNA along the vegetal cortex (By similarity).