PharMolix/UniProtQA huggingface dataset:
Protein: PURT_NOSS1
Sequence: MSKAIKLPQKLMLLGSGELGKEFVIAAQRLGNYVIAVDRYANAPAMQVSDCCEVISMLSADDLEAVVTKYEPDFIIPEIEAIRTEKLQEFEDRGITVIPTAAATNYTMNRDRIRELAHEELGIRTAKYGYAVTLEELIAVSDNIGFPNVVKPVMSSSGKGQSVVATKEEVEKAWDYAIANSRGDSQKVIVEEFINFEIEITLLTIKQWNAPTIFCSPIGHRQERGDYQESWQPAGISEDKILEAQAIAKTVTDALGGAGIFGVEFFITKDEVIFSELSPRPHDTGMVTLISQNLNEFELHLRAILGLPIPKIEQLGFCASAVILASEKLDAPLFTGVAEALAEPDVDIRLFGKPTAHPYRRMGVALAKAENVETAREKATDAASKIHISSQ
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: RSMG_BRUSI
Sequence: MSADIRFDSLKTIVPAVSRETADRLIAFEDLFRKWSKAINLASPSTLADLWNRHILDSAQLFPLAKEATRWLDIGSGGGFPGIVTACFLAERSGGCIDLVESAGKKAAFLRTAAGHLHVPARVHSARIESMWEKIETPQVVTARALASLGDLFTLAEPWLSDGAKALFQKGRDYQREIDESRVGWSFDLVKHPSAIDQASVILEISNLRRKTD
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMK_HAES1
Sequence: MKLLMLCREPRLYSCQRLKESAEDNGHQIDILDPNRCLLKLSKNAPHFELYYQVNSKSEPYLLPDYDAIIPRFGSTSTRMGCAVLRHFRTKNIFCLNDDVAFLKARDKWLSLQLLTEQGIAVPNSALSGAEFSATQAILQIQSPTILKTLHGSQGIGVILAENRKSAVSIMETLTQADVPLLMQDFIQEAQGTDIRCFVIGDKVVATMQRIGQEDEFRANFHRGGSAEKIQLTEQEKVLALKATKCLGLDVAGVDLIRSKQGLLVLEVNASPGLEMIEKTSGIDIALQMIVHIEKQFKR
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: ITRB_SOYBN
Sequence: DFVLDNEGNPLSNGGTYYILSDITAFGGIRAAPTGNERCPLTVVQSRNELDKGIGTIISSPFRIRFIAEGNPLRLKFDSFAVIMLCVGIPTEWSVVEDLPEGPAVKIGENKDAVDGWFRIERVSDDEFNNYKLVFCTQQAEDDKCGDIGISIDHDDGTRRLVVSKNKPLVVQFQKVDKESL
What is the function of this protein?
Inhibition of trypsin.
What are the official names of this protein?
Trypsin inhibitor B, Kunitz-type trypsin inhibitor B.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.
Protein: NUOC_FRAT1
Sequence: MIVSTKLQDHFDKITKILSGFGVEGCISYGEITFSIRDQRDIHLILKKLKKEYLFEQLTDVTAVDYLTYGQSDWQVGKVVSQTGFSRGRQQDFKTAAVDNRFEIIYQLLSMANNVRIRVKCKLKDAQIILVDSVSDLWPSANWAEREVYDMFGIYFNNHPDLRRVLTDYGFVGHPLRKDFPQTGYVEMRYDENLGRVVYEPVEIDDRVNTPRVIRN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACDH_POLSJ
Sequence: MTKSQRLQVAIIGSGNIGTDLMIKVMRNSKHLSMGAMVGIDAASDGLARAGRLGVPVTHEGITGLVGLPNFGDIRIAFDATSAGAHAGHNEVLQRHGVKVIDLTPAAIGPYVIPVVNLEEQLSSPNINMVTCGGQATIPIVRAVSQIARVRYAEIVASIASKSAGPGTRANIDEFTETTSAAIVSVGRAEHGKAIIVLNPAEPSLMMRDTVFCLVDADADQEAIRLSVRDMVRSVAAYVPGYRLKQDVQFDVIPDKAPVNVPGIGRVSGLKVSVFLEVEGAAHYLPAYAGNLDIMTSAALAAADKIAASLITAR
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: VPB39_MYCTO
Sequence: MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Antitoxin VapB39.
Protein: RNH2_PSEPG
Sequence: MQIGLDFNLVEDLVAGVDEVGRGPLCGAVVTAAVILDPARPILGLNDSKKLTEAKREALFDEICEKALSFCIARAEVEEIDRLNILQATMLAMQRAVEGLHITPKLALIDGNRCPKLAVPASPVVKGDSQVPAIAAASILAKVTRDREMSAFELIYPGYGIGGHKGYPTPVHLEALARLGPTPIHRRSFAPVRAAWEAREGVTDSLI
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC1_PROM5
Sequence: MTNSNLRTENHFDYVKISIASPQRIMDWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCEKIFGPSKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGYIKLAAPVSHVWYLKGIPSYVAILLDIPLRDVEQIVYFNCYVVLDVGDHKDLKYKQLLTEDEWLEIEDEIYAEDSTIENEPFVGIGAEALKQLLEDLDLNQIAEELREEITNSKGQKRAKLIKRIRVIDNFIATNAKPEWMVLDAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRALKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKMHQCGLPKEMAIELFQPFVIHRLIRQNIVNNIKAAKKLIQKADDEVMQVLQEVIEGHPILLNRAPTLHRLGIQAFEPKLVGGRAIQLHPLVCPAFNADFDGDQMAVHVPLALEAQTEARMLMLASNNILSPATGEPIVTPSQDMVLGSYYLTALQPNFKKPNFGDNQRTYASLEDVIFAFEDKRVGLHEWVWLRFNGEVDDDEESKTPQETKELEDGSKLEIWNFRRDRFDSQNNLISRFILTTVGRVVMNHTIIDSVSKT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: GLYA_CAMC1
Sequence: MSLQSYDKDIYDLVNLELKRQCDHLEMIASENFTYPEVMEVMGSILTNKYAEGYPGKRYYGGCEFVDEIEQIAIDRCKELFGCEFANVQPNSGSQANQGVYGALLNPGDKILGMDLSHGGHLTHGAKVSSSGKMYESFFYGVELDGRINYDRVMDIAKIVKPKMIVCGASAYTREIEFKKFREIADAVGAILFADVAHIAGLVVAGEHQNPFPHCDVVSSTTHKTLRGPRGGIIMTNNEEYAKKINSSIFPGIQGGPLVHVIAAKAVGFKHNLSPEWKIYAKQVKANAKKLGKVLISRGFDLVSGGTDNHLILMSFLNRDFSGKDADIALGNAGITVNKNTVPGETRSPFITSGIRVGSPALTARGMKEAEFELIANKIADVLSDINNASLQEKIKGELKELAHKFIIYDKATF
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_CLOP1
Sequence: MKEFDTIAAIATALGEGGIAIIRVSGNKALEIVNKIFRGINGKDLLDIKPYTMRYGHMIDENNEIIDEVIVSFMKGPRSFTAEDTVEINCHGGIVATNKVLQNVIKAGARLAEPGEFTKRAFLNGRIDLSQAEAVMDIITAKTELSMKSAMTQSQGRLSTEINNLRKEALDILALIEYAVDFTEDDEEPDETIPVKVKEDVITLRGKVNNLIDTADEGKLIRDGLSMVIVGKPNVGKSSLLNALLNEKRAIVTDIAGTTRDVIEEYINLDGIPVRLVDTAGIRETEDVVEKIGVEKSKEKINEADLVILMLDTSRELDEEDKEIIDYIKDRKYIVLLNKVDLDRKLSSEIVDNLENKIELSAKTGFGIDDLKSKIKDLFFNGSIDAESVMVTNTRHKEALYRASENLDGALNGLNNNEFLDLVSIYVTSALRALGEITGAELEEDLVNKIFAEFCCGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAC_CYACA
Sequence: MVHVVKIYDTCIGCTQCVRACPCDVLEMVPWDGCKASQIASSPRTEDCIGCKRCETACPTDFLSIRVYLGAETSRSMGLTY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: GLMU_WOLTR
Sequence: MFIILAAGHGKRMNSGLPKVLHKIGNFSMLQHIIYNARQLNPENISVVANLPLIERLKCLEDIQLITQESTLGTGDAVKTAVRNMKELSDSNIIVVQYGDTPLIKNSTITQMVSCLEGKALVCLGFKTSNKEYGRLIIENGSLREIVETQDDENSDEEFLANAGIMVAYAKNLRELVEKIECNGSTYEYYLTDIVSIAVKSNLNVGYVTTDEEEATGINSRNDLAKAEFYFQENRRKFFTDSGVTLVAPETVFFSLDTQIGMDSIIYPYVFFGPGVRIGPGAKIGPFTKCEDTTIGDGAIVGNFVEAKASDIGTNTKIKHLSYIGNTEVGRESNIGAGTVVCNYDGKKKHRTNIGSNCFVGANSSLIAPLNVHDESVIAAGSIIVKDVPKKRLVITRRKQMVKKIK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIRB5_AGRT9
Sequence: MKTTQLIATVLTCSFLYIQPARAQFVVSDPATEAETLATALATAENLTQTIAMVTMLTSAYGVTGLLTSLNQKNQYPSTKDLDNEMFSPRMPMSTTARAITSDTDRAVVGSDAEADLLRSQITGSANSAGIAADNLETMDKRLTANADTSAQLSRSRNIMQATVTNGLLLKQIHDAMIQNVQATNLLTMATAQAGLHEAEEAAAQRKEHQKTAVIFGALP
What is the function of this protein?
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
What are the official names of this protein?
Protein virB5.
What is the protein family that this protein belongs to?
Belongs to the virb5 family.
Protein: CWP26_TOBAC
Sequence: GXNNVDAARK
What are the official names of this protein?
28 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: NOVE_STRNV
Sequence: MVASGRTASKGRGNGATPVRPTAGDATPVDSGQPSDTTYGGLEVSAERTRLRIPRDLSLEAWCRLGGRILAVCDSSVWWIGDWLVFGQNQYGDRYRRAMKETKLDYQTLRNYAWVARKFEPSRRRDSLTFQHHMEVAALSEAEQDHWLDFAVRLNWSRNELRKQIRASLSGEEDDLRCEVQLNLQLDELRLERWREAARGSNLTLTDWILSVVDGAV
What is the function of this protein?
Transcription regulator that specifically regulates expression of genes involved in the novobiocin biosynthesis pathway.  Probably acts as a positive regulator of transcription.  Does not bind DNA.
What are the official names of this protein?
Transcriptional regulator NovE, Novobiocin biosynthesis protein E.
Protein: DAPF_MYCLB
Sequence: MIFAKGHGTQNDFVVLPDVEADVTFTAAQVAALCNRRQGLGADGVLRVTTAGAAVTAGVLEHLPDGVSCSDWYMDYRNADGSVAQMCGNGVRVFAHYLRASGLESCDEFVVGSLAGPRLVNVHHVDELNADVTVDMGKANLLGSGGPAFAVTVGGRRFSGVAVDVGNPHLACMDPQLSLEELAALDLGAPVHLDRVQFPDGVNIEVLTAPVDGMVQMRVHERGVGETRSCGTGTVAAAVAALASAGADTGTLTVRVPGGDVVITITDVTSYLRGPSVLVAHGELADAWWYSLARSC
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_BURM1
Sequence: MSDHDSGNARRGRASFGAFVRKPVERGAPAGAAAEQGGLDAVQALPDDAVEVGAVVDAYGLKGWVKVATHADAGRGGDALLSARRWWLEKGTQRFSARIVQSKTHGDTVVAQPAGVGDRDAALALRGFRVFVRREDFPALAADEFYWVDLIGLDVVNEQSATLGKVVGMIDNGAHSIMRVEYPSVGKDGRPAAAERLIPFVGVYVKTVDQAARRIVVDWEADY
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_PSEU2
Sequence: MMQTGLDFTLVEDLVAGVDEVGRGPLCGAVVTAAVILDPTRPILGLNDSKKLTEARREKLYVEIQEKALCWFIARAEVEEIDQLNILHATMLAMQRAVEGLSITPRLALIDGNRCPQLSVPSAPVVKGDSKVPAIAAASILAKVSRDREMAAFELIYPGYGIGGHKGYPTPVHLEALARLGPTPIHRRSFAPVRAAHEARATIMMGGSISPSVGLLQD
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FETP_XANC5
Sequence: MSRTVFCHYQQSDAEGLDFVPYPGELGQRIFVQIGKTAWQAWLAHQTMLINENRLSPRDPKHRAFLEAELQKFLFERNADKPEGYVAPVRD
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: PRP45_CRYNJ
Sequence: MIHSHNNNLSFCSQLITVRKMAALTRALPAPLHTSTTEYEEAPAPLPTTPGPQLPKYGQRKGWKPKTAADFNGGGAYPECHVAQYPLDMGKKNKGQGSTLALQVDQDGLVRYDAIAQHGRAPGSRVQSSFKDLVPLANRTDVTESERQMERPDDLSVAETAERTRLALERITHGKIKAAQPKHVPKTNSDATYIRYTPANQSADEGKQRIIKMTEVQEDPLEPPRFKHKKIPRGPAEPPPPVLQSPPRAATAQDQKDWMIPPCISNWKNNKGYTIPLDKRLAADGRGLQDVHINDNFAKFSESLYIADRHIREEVRARAQLQQLLAQKQKTSKEEELRLLAQRAREDRSGLSSSVSGSVAAASASRLPAETGINLGGYGSESGSEEESDEEEEDEEAIRERNIVREEKRREREKEMRMSNMGSEMRAKMLAKEANRDISEKIALGLAKPSASKETLLDSRLFNREALSTGFASEDSYNLYDKPLFAGSSAAAAIYRPAGSSRNDESFGGGTEEGIKEEMSKDRFQLGNATRGFEGAEGVEAREGPVQFEKDTIVALDGSADPFGVEQFMDAARRGGKRTAEDRDEERRKRARDE
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-processing protein 45.
What is the protein family that this protein belongs to?
Belongs to the SNW family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBA_MEDSA
Sequence: MTAILERRDSETLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIICGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEAPSING
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PTH_POLNS
Sequence: MTKLIVGLGNPGEEHEEDRHNAGFWFVDALAKQLGVRFESEKRFHGKVAKAKWEGEDLFLLKPSTYMNLSGQSVGALCRFHKIMPADILVVQDELDIKPGSARLKLGGGTGGHNGLKDIQAHLSTPNYWRLRLGIGHPRDIAGDGRPMDVADYVLRRPQLTEQKLINTSIENGLNILSLFLKGDTQTAMMELHSKG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADHX_RAT
Sequence: MANQVIRCKAAVAWEAGKPLSIEEIEVAPPQAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKPILHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGATECINPQDFSKSIQEVLIEMTDGGVDFSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINKAFDLMHSGNSIRTVLKM
What is the function of this protein?
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.  Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate.  Class-III ADH is remarkably ineffective in oxidizing ethanol.  Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
What are the official names of this protein?
Alcohol dehydrogenase class-3, Alcohol dehydrogenase 2, Alcohol dehydrogenase 5, Alcohol dehydrogenase B2, ADH-B2, Alcohol dehydrogenase class-III, Glutathione-dependent formaldehyde dehydrogenase, FALDH, FDH, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RKD1_PYRCJ
Sequence: MATIRGIVISKQLVYDPSGARYIKVDIIEEKELPGPVAAFSAQDEQTAQLMREVMPLVTQIVRSLPFGGGKIAVPRLTLWLTDEELEMFGDVDVGDVVLISVENGEIKVKPEA
What is the function of this protein?
Part of an actin-like archaeal cytoskeleton.
What are the official names of this protein?
Arcadin-1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Forms cell-spanning helical structures. Colocalizes with crenactin.
Protein: PAFA_CORA7
Sequence: MEQPSDSAPVYARRIMGIETEYGITASASNGQRVMSPDEIARVLFRPIVSKYSSSNIFSPNASRLYLDVGSHPEIATAECDSLSQLIAYERAGDAMVNRMAVQAEETLADEGEKRAVYLFKNNVDSAGNSYGCHENYLIGRHVVLKDLGKALLPFMITRQLICGVGMIRPAKGDDPACFVLSQRADQVWEGVSSATTRSRPIINTRDEPHGDSKRFRRMHVIVGDSNMAEPTMALKVGSTLLMLEMLEAGFEVPNLSVLEPIQHIRAIALDPTGRTELPLEGGGSTTALAVQQELCTAAERWLEHREEAGTPTTELARVVDLWKRTLQAIDTQDFSSVDREIDWVIKRSLLNRYRDRLGGDWAHPKLAQIDLTYHDIRPGRGLYSVLEQRGMVERWIDDAAIDAAIDTAPQTTRAKLRGEFLAVARELDAAVTVDWTRMKVNRPEPMTEEFSDPFVSEDPRLDGLLDYMRSHPGS
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: MBL2_GIBM7
Sequence: MVFDLGVRKDWENLPETFVAGIKGSGCKIEVQTDVASLLQENGQSLDDVGAVIWSHWHFDHAGDPQTFPGTTDLIVGPGFKSNIIPAYPTVRDSHVNETAWEGRELIEIDFKGDKGLKIGKFDAYDFYGDGSFYLLSSPGHAVGHMSALARTTADPPSFMLLGGDIAHHCGEFRPSPYTPLPEMMSPNPLGRTLSACPGRLFLNIHPWKDPERPFFDPTTEPGWHLEAAEAKQSIDKLI
What is the function of this protein?
Gamma-lactamase; part of the Fusarium detoxification of benzoxazolinone cluster 2 (FDB2) involved in the degradation of benzoxazolinones produced by the host plant (PubMed:19302487, PubMed:26808652).  Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).  The first step in the detoxification of benzoxazolinones involves the hydrolysis of the cyclic ester bond of benzoxazolinones by the FDB1 cluster gamma-lactamase MBL1 to aminophenols (PubMed:26808652, PubMed:12788712).  MBL1 is able to convert BOA into 2-aminophenol (2-AP), as well as MBOA into 5-methoxy-2-aminophenol (2-AMP) (PubMed:26808652, PubMed:12788712).  The FDB2 cluster N-malonyltransferase FDB2/NAT1 then metabolizes aminophenols via N-malonylation to non-toxic malonamic acids (PubMed:19302487, PubMed:12788712).  FDB2/NAT1 converts 2-AP into N-(2-hydroxyphenyl) malonamic acid (HPMA) and 2-AMP into N-(2-hydroxy-4-methoxyphenyl) malonamic acid (HMPMA) (PubMed:19302487, PubMed:12788712).  The duplicated dienlactone hydrolases DLH1 and DLH2 may provide redundant function for hydrolyzing the lactone moiety in the BOA molecule (Probable).  The roles of the amidases and other enzymes encoded by the 2 FDB clusters have not been identified so far (Probable).
What are the official names of this protein?
Gamma-lactamase MBL2, Fusarium detoxification of benzoxazolinone cluster 2 protein MBL2, FDB2 cluster protein MBL2, Metallo-beta-lactamase 2.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: RSKA_MYCSJ
Sequence: MTEPNNTDLLDLATPYALHAVSIDERFEIDRWLATAPPEVADAFTDEVRSVQETMAVLSAATATEPPAHLRDNVLAMVADDPVRDLGSARRRRGGESRWRTAVLAAAAVAVVGLGALGVGLALRPAVSPTTADQVFAAPDVQTVSGPIPGGGTATVVFSKERDAGVLVMNDVAPPKPGTVYQMWLVGSDGPHSAGTMDDKAISPSTTAVLSDIGTSQALAFTVEPPGGSQRPTSPAFAELPLT
What is the function of this protein?
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK.  ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP).  RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses.  The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor (By similarity).
What are the official names of this protein?
Anti-sigma-K factor RskA, Regulator of SigK, Sigma-K anti-sigma factor RskA.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-K factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.