PharMolix/UniProtQA huggingface dataset:
Protein: MET_PONAB
Sequence: MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETLIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHPLNQNGYTLVVTGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECSSGTWTQQICLPAIYKVFPSSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNILKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITGISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISIALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.  Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.  Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.  Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.  During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.  In adults, participates in wound healing as well as organ regeneration and tissue remodeling.  Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TSGA_ECO55
Sequence: MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFLLMVLAVAGLMFSHSLALFSAAMFILGVVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMIAAFLLARSIEWYWVYACIGLVYVAIFILTFGCEFPALGKHAPKTDAPVEKEKWGIGVLFLSVAALCYILGQLGFISWVPEYAKGLGMSLNDAGTLVSNFWMSYMVGMWAFSFILRFFDLQRILTVLAGLAAILMYVFNTGTPAHMAWSILALGFFSSAIYTTIITLGSQQTKVPSPKLVNFVLTCGTIGTMLTFVVTGPIVEHSGPQAALLTANGLYAVVFVMCFLLGFVSRHRQHNTLTSH
What are the official names of this protein?
Protein TsgA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BIOB_SALG2
Sequence: MARHPRWTLSQVTELFEKPLLELLFEAQQIHRQHFDPQQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLEAERLMAVEQVLDSARKAKNAGSTRFCMGAAWKNPHERDMPYLEQIVQGVKAMGLETCMTLGMLNESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVREAGIKVCSGGIVGLGETVTDRAGLLLQLANLPTPPESVPINMLVKVKGTPLADNDDVDAFDFIRTIAVARIMMPTSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPAEDKDLQLFRKLGLNPQQTRVLAGDNEQQQRLEQTLMTPDTDDYYNAAAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RIR1_ARATH
Sequence: MYVVKRDGRQETVHFDKITARLKKLSYGLSSDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTCNHPDYASLAARIAVSNLHKNTKKSFSETIKDMFYHVNDRSGLKSPLIADDVFEIIMQNAARLDSEIIYDRDFEYDYFGFKTLERSYLLKVQGTVVERPQHMLMRVAVGIHKDDIDSVIQTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLVCMKDDSIEGIYETLKECAVISKSAGGIGVSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAVYLEPWHADVYEFLELRKNHGKEEHRARDLFYALWLPDLFMERVQNNGQWSLFCPNEAPGLADCWGAEFETLYTKYEREGKAKKVVQAQQLWYEILTSQVETGTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKGVPLDSHPPKLAGSLDSKNRYFDFEKLAEVTATVTVNLNKIIDVNYYPVETAKTSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASTELAARLGPYETYAGSPVSKGILQPDMWNVIPSDRWDWAVLRDMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTDMGLWTPTLKNKLINENGSIVNVAEIPDDLKAIYRTVWEIKQRTVVDMAADRGCYIDQSQSLNIHMDKPNFAKLTSLHFYTWKKGLKTGMYYLRSRAAADAIKFTVDTAMLKEKPSVAEGDKEVEEEDNETKLAQMVCSLTNPEECLACGS
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.  R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide.  Ribonucleotide reductase (RNR) complex function is essential for efficient organellar DNA degradation in pollen.  Involved in chloroplast division.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase large subunit, Protein DEFECTIVE IN POLLEN DNA DEGRADATION 2, Ribonucleoside-diphosphate reductase R1 subunit, AtRNR1.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATC1_BOVIN
Sequence: MTEFWLISAPGEKTCQQTWEKLHAATTKNNNLAVSSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTMKKLREVLYELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32764564).  Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit C 1, V-ATPase subunit C 1, Vacuolar proton pump subunit C 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase C subunit family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein.
Protein: ARGP_YERE8
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENLFGQPLLVRTVPPRPTEQGQKLLALLHQVELLEEEWLGNDNGGDTPLLLSLAVNADSLATWLLPALKPVLADSPIRLNLQVEDETRTQERLRRGEVVGAVSIQPQPLPSCLVDQLGALDYLFVASKPFAERYFPNGVTRSALLKAPAVAFDHLDDMHQAFLQQNFDLSPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELASGELINLTPGLLQRRMLFWHRFAPESRTMRKVTDALLSYGRQVLRQD
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: CTA1A_CONMR
Sequence: MRCLPVLIILLLLTASAPGVVVLPKTEDDVPMSSVYGNGKSILRGILRNGVCCGYKLCHPC
What is the function of this protein?
Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2).
What are the official names of this protein?
Chi-conotoxin MrIA, Chi-MrIA, Conotoxin MrIA, Lambda-conotoxin CMrVIB, Mr10.1, Xen2174, mr10a.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: QRIC1_MOUSE
Sequence: MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQVQVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQQQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPKALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTAQEQTPPPQQQQQQLQVTCSAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKSPSNPKDKSTSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAIAVANATTMH
What is the function of this protein?
Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352).  Controls the outcome of the unfolded protein response (UPR), an ER-stress response pathway that either promotes recovery of ER homeostasis and cell survival, or triggers the terminal UPR which elicits programmed cell death when ER stress is prolonged and unresolved (PubMed:33384352).  ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (By similarity).  May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (By similarity).  Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress.  Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352).  Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).
What are the official names of this protein?
Transcriptional regulator QRICH1, Glutamine-rich protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane.
Protein: KCY_BACC4
Sequence: MDKRISIAIDGPAAAGKSTVAKVVAKELSYVYIDTGAMYRTLTYAALEQKVDIENEEQLMEVVKNVNIEFQQGENTQLVFLNGQDVSEVIRTPDVTNRVSIVAKHRLVREEMVRRQQELAKKGGVVMDGRDIGTHVLPDAEVKIFMLASVEERAERRHLENLNKGFDSNLEQLKEEIAQRDKLDSEREVSPLKKADDALELDTTSLSIEEVVQKIMSIVSGVFAK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_HAEIN
Sequence: MGKSVVILGAQWGDEGKGKIVDLLTDRVKYVVRYQGGHNAGHTLIINGEKTVLRLIPSGMLHPNVTCLIGNGVVVSPEALMKEMGELESRGIKVRERLLISEACPLILPYHVAMDHAREAALGKKAIGTTGRGIGPAYEDKVARRGLRVGDLFNKEAFAEKLKNILEYYNFQLVNYYKVEPVDYQKTLDDVMAIADVITGMVADITTILDTARKNGEHILFEGAQGTMLDIDHGTYPYVTSSNTTAGGVATGSGFGPRNLDYVLGIIKAYCTRVGGGPFTTELFDDVGAEIARKGNEFGAVTGRPRRCGWFDAVAIRRAIQLNSISGFCMTKLDVLDGFDEVKICVAYKMPNGEIVEYAPLAAKDWEGVEPIYETLPGWKENTFRITDVNKLPQNCINYIKRIEEVTGVPIDILSTGPDRVETMILREPFAA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCZL_BACSU
Sequence: MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSAKSCSTPLYIRRSIQFKS
What are the official names of this protein?
Uncharacterized protein YczL.
Protein: SELD_CLOD6
Sequence: MKKEQKKLTEMTTAGGUAAKIGPEVLASVLSQLPKNDNIENLLVGLDTADDAAVYKLNDDMALIQTLDFFTPMVDDPYVFGQIAASNSLSDVYAMGGKPLVAMNIVCFPSCHDMDVLAEILKGGFDKVKESGALLVGGHTVDDKEPKYGLSVSGIVSPNKVLSNATAKPGDKLIITKPIGVGVLNTAMKEGMVEQHIADKVIEIMIHLNKYAAMSFEKFDVNSVTDITGFGLLGHTLEMAKASEVSIEIESKHVPIIEGAIEMAQMGIIPAGMYKNMHYVSKDVEVVGNIEVAVQDILYDPQTSGGLLISVKEELAEELVKDMKLNGAIEAKIIGSVVPKGEKYITVL
What is the function of this protein?
Synthesizes selenophosphate from selenide and ATP.
What are the official names of this protein?
Selenide, water dikinase, Selenium donor protein, Selenophosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Protein: RL27_CAEEL
Sequence: MGKIMKPGKVVLVLRGKYAGRKAVVVKQQDEGVSDRTYPHAIIAGIDRYPLKVTKDMGKKKIEKRNKLKPFLKVVSYTHLLPTRYSVDVAFDKTNINKEALKAPSKKRKALVEVKSKFEERYKTGKNKWFFTKLRF
What is the function of this protein?
Component of the large ribosomal subunit.
What are the official names of this protein?
60S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL27 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: SAU19_ARATH
Sequence: MAFVRSLLGAKKILSRSTAAGSAAPKGFLAVYVGESQKKRYLVPLSYLSQPSFQALLSKSEEEFGFAHPMGGLTIPCPEDTFINVTSRLQ
What is the function of this protein?
Provide a mechanistic link between auxin and plasma membrane H(+)-ATPases (PM H(+)-ATPases, e. g.  AHA1 and AHA2), and triggers PM H(+)-ATPases activity by promoting phosphorylation of their C-terminal autoinhibitory domain as a result of PP2C-D subfamily of type 2C phosphatases inhibition, thus leading to the acidification of the apoplast and the facilitation of solutes and water uptake to drive cell expansion (PubMed:24858935, PubMed:27999086).  Prevents the apical hook maintenance of etiolated seedlings (PubMed:24858935).  Functions as positive effectors of cell expansion through modulation of auxin transport (PubMed:22348445, PubMed:27999086).
What are the official names of this protein?
Auxin-responsive protein SAUR19, Protein SMALL AUXIN UP RNA 19.
What is the protein family that this protein belongs to?
Belongs to the ARG7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ERFB_EMENI
Sequence: MAFQFSNNPESNETTNNPAPHVLGLPRPPSVGGISSRVTDMSEDGDQSQTNTMSSHVPHRHSVSRRGPPPARSSIASTSQITNRPGSSASRLSRTHIPSLAASGFFRPMSSQRLQAHRGRPATNHTVSTEDWGDQMNQNRRSLISNSTFPNSLSAADQEVPPSRGTEFTDPIIPDRIHSNASPTANTTTVRSESANLIRDRERPPHLNLKVDYKGTNENETPERSPLSFLSLQNRNAPADNRDSRAHARLSSADSSPQSIEKKPELAKSRNKGRNYEYFVGNTIFLGGGRFQNSRDKPVNIATGLLVLVPTGLFFGFSGPWLWHNISPAIPVLFAYVFYLCFSSFIHASVVDPGVIPRNLHQMPPVDPSQDPLAIGPPTNDWVMVKLATSDVAAMDVPVKYCKTCSIWRPPRCYHCRVCDNCIETLDHHCVWLNNCVGRRNYRYFFAFVSTSTLLALFLLGASLAHILVYRSREGISFSDAIDKWRVPFAMVIYGALAAPYPASLWAYHLFLVGRGETTREYLNSHKFAKADRHRPFTQGNVIRNWIAVFGRPRPPTYMQFKEYYQEGDQRLSTVKRRFLPRNTEPQNDIEMQHVPPPNSA
What is the function of this protein?
Palmitoyltransferase specific for Ras proteins.
What are the official names of this protein?
Palmitoyltransferase erf2, DHHC cysteine-rich domain-containing protein erf2, Ras protein acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: UVRA_BRUA2
Sequence: MSDQKFISIRGAREHNLKNVDLDLPRDKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLEMMQKPDVDQIDGLSPAISIEQKTTSRNPRSTVGTVTEIYDYMRLLFARVGIPYSPATGLPIESQTVSQMVDRVIALEEGTRLYILAPIVRGRKGEYRKELAELQKKGFQRVKVDGTFYEIADVPPLDKKYKHDIDVVVDRVVVRPDLSTRLADSLETCLKLADGLAIAEFADKPLPVGETAEGGSANKSANETHERILFSEKFACPVSGFTIPEIEPRLFSFNNPFGACPTCDGLGTQQAIDPNLIIPDESAALKDGAVAPWARSSSPYYNQTLEALGKAYGFKVSARWSELSEEARQAILYGTKGREITFHYDDGLRSYQTTKPFEGVIPNLERRWKETDSAWSREEIERFMASTPCPACNGYRLKPEALSVKIGKKHIGEITEMSIRKADAWFRDIDGSFNEKQREIAARILKAIRERLQFLNNVGLDYLTLARNSGTLSGGESQRIRLASQIGSGLTGVLYVLDEPSIGLHQRDNARLLDTLRHLRDLGNTVIVVEHDEDAILTADYVVDIGPAAGVHGGKVIAQGSPQDIMANTNSLTGKYLSGAMEVAVPAERRKISKTKRLRVVGARGNNLKNVSADIPLGTFTAVTGVSGGGKSTFLIETLFKAASRRIMGSREHPAEHDRIEGLEFLDKVIDIDQSPIGRTPRSNPATYTGAFTPIRDWFAGLPEAKARGYQPGRFSFNVKGGRCEACQGDGVIKIEMHFLPDVYVTCDVCHGKRYNRETLDVLFKGKSIADVLDMTVEEGAEFFSAVPAVRDKLETLVKVGLGYIKVGQQATTLSGGEAQRVKLAKELSRRATGRTLYILDEPTTGLHFHDVAKLLEVLHELVEQGNTVVVIEHNLEVIKTADWVIDLGPEGGDGGGEIVAVGRPEDIVQEKRSYTGQFLKELLERRPKRSSQAAE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrA is an ATPase and a DNA-binding protein.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
What are the official names of this protein?
UvrABC system protein A, UvrA protein, Excinuclease ABC subunit A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. UvrA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GB_BHV1P
Sequence: MAARGGAERAAGAGDGRRGQRRHLRPGRVLAALRGPAAPGAGGARAALAAALLWATWALLLAAPAAGRPATTPPAPPPEEAASPAPPASPSPPGPDGDDAASPDNSTDVRAALRLAQAAGENSRFFVCPPPSGATVVRLAPARPCPEYGLGRNYTEGIGVIYKENIAPYTFKAIIYYKNVIVTTTWAGSTYAAITNQYTDRVPVGMGEITDLVDKKWRCLSKAEYLRSGRKVVAFDRDDDPWEAPLKPARLSAPGVRGWHTTDDVYTALGSAGLYRTGTSVNCIVEEVEARSVYPYDSFALSTGDIIYMSPFYGLREGAHREHTSYSPERFQQIEGYYKRDMATGRRLKEPVSRNFLRTQHVTVAWDWVPKRKNVCSLAKWREADEMLRDESRGNFRFTARSLSATFVSDSHTFALQNVPLSDCVIEEAEAAVERVYRERYNGTHVLSGSLETYLARGGFVVAFRPMLSNELAKLYLQELARSNGTLEGLFAAAAPKPGPRRARRPRRLRPAPGRGQRARRRRHAGGRVTTVSLAEFAALQFTHDHTRTSEHHVHRLASPWCLLQNKERALWAEAAKLNPSAAASAALDRRAAARMLGDAMAVTYCHELGEGRCSSRTRMRAPGGVCYSRRGSFFGNESEPVEGQLGEDNELLPGRELVEPCTANHKRYFRFGADYVYYENYAYVRRVPLAELEVISTFVDLNLTVLEDREFLPLEVYTRAELADTGLLDYSEIQRRNQLHELRFYDIDRVVKTDGNMAIMRGLANFFQGLGAVGQAVGTVVLGAAGAALSTVSGIASFIANPFGALATGLLVLAGLVAAFLAYRYISRLRSNPMKALYPITTRALKDDPGRNRPGEEEEEFDAAKLEQAREMIKYMSLVSAVERQEHKAKKSNKAARLLATRLTQLALRRRAPPEYQQLPMADVGGA
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: ASTE_BURO0
Sequence: MPAAALLDDFLAFTLAGEAPAERDGACAGGAVRWQWLGDGLLAFEPAAADAAARASVLVSAGVHGDETAPIELLSMLVRDFAAGALPLACRLLVVLGNVPAMRAGERYLDDDLNRLFSGRHAQVPASREAPRAAQLEAAASAFFAAAPAGSARWHIDMHTAIRASVFEQFALLPHTGTPPTRAMVEWLGDARIAAVLLHTAKGNTYSHFTAEHCGALACTLELGKVRPFGQNDLTRFAPADRAVRKLVSGERAEGGATLPRVFTVIDQITKQSDALELFVAADVANFTAFARGTVLAQDGDYRYTVKHDEERIVFPNPTVKPGLRAGLLVVDTTRDTLAALV
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: GRA16_GIBZE
Sequence: MVKILPPTASIDWDQISIATNLGLGHVESTYHMSTGRWSDPVFVNDPYLRVHGLAPGLQYAFRTPKGRVSIFRPDKHAKRMSHSTSTISIPNIPESLFLASVELAVTSNSSYVPPHTSRAMLYIRPFAFGSSEMIGLVPPSEYKFCVYVKPVPAYHGLSAQDALILTGFDRAAPHGLGHAKVGGNYAPVIKWSEQAKADGFGMTLHLDSKTRTEIDEFSTSGFLGIKVSDEGAVKVVAPSSPCIIDSTTSDCCLQLARHYGWNVEKRPIKYTELPEFSEVVAVGTAASVVSIRSITLEDSRETVRYLDATTNQGRYARKLSTSLDDIMHCRVEDVFGWCHQVGEAPVEDVPTRKMGSSNKKPAFVDIMTLSCAGQGARFSCH
What is the function of this protein?
Aminotransferase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461).  The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable).  The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable).  The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable).  Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable).  On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable).  Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable).  The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable).  The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable).  The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
What are the official names of this protein?
Aminotransferase FGSG_00049, Gramillins biosynthesis cluster protein FGSG_00049.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: CARA_SCHPO
Sequence: MLRFLKPFPLRFGKRFYSKVPPVTNHERILPKQPSFPTAPAQNEIATLTIRNGPIFHGTSFGANRNVSGEAVFTTSPVGYVESLTDPSYKQQILIFTQPLIGNYGVPDCKKRDENGLLRHFESPHIQCAGVVVNDYATKYSHWTAVESLGEWCAREGVAAITGVDTRAIVTFLREQGSSLAKISIGEEYDANDDEAFINPEEVNLVSQVSTREPFFVSGGDGMLNIAVIDCGVKENILRSLVSRGASVTVFPFDYPIQNVASNYDGIFLTNGPGDPTHLTKTVNNLRELMNTYNGPIMGICMGHQLLALSTGAKTIKLKYGNRGHNIPALDIASGNCHITSQNHGYAVDASTLPAEWKATWTNLNDQSNEGIAHVSRPISSVQFHPEARGGPMDTFYLFDNYIKEAIKYQKSRTA
What are the official names of this protein?
Carbamoyl-phosphate synthase arginine-specific small chain, CPS-A, Arginine-specific carbamoyl-phosphate synthetase, glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
What are the subcellular locations of this protein?
Cytoplasm.