PharMolix/UniProtQA huggingface dataset:
Protein: ATP6_GORGO
Sequence: MNENLFASFIAPTILGLPAAVLIILLPPLLIPTSKYLINNRLIATQQWLIQLTSKQMMTMHNAKGRTWSLMLMWLIIFIATTNLLGLLPHSFTPTTQLSMNLAMAIPLWAGAVTTGFRSKTKNALAHLLPQGTPTPLIPMLVIIETISLFIQPMALAVRLTANITAGHLLMHLIGSATLAMSTTNLPSTLIIFTVLILLTMLEIAVALIQAYVFTLLVSLYLHENT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CINA_STRPD
Sequence: MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQTLAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPMVNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQLLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKMLGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDVRYIATLHAFNMVRKTLLKLENLL
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: FUN19_YEAST
Sequence: MGLYSPESEKSQLNMNYIGKDDSQSIFRRLNQNLKASNNNNDSNKNGLNMSDYSNNSPYGRSYDVRINQNSQNNGNGCFSGSIDSLVDEHIIPSPPLSPKLESKISHNGSPRMASSVLVGSTPKGAVENVLFVKPVWPNGLSRKRYRYATYGFLSQYKIFSNLAQPYSKNIINRYNNLAYNARHKYSKYNDDMTPPPLPSSSSRLPSPLASPNLNRQARYNMRKQALYNNNLGKFESDTEWIPRKRKVYSPQRRTMTTSPHRAKKFSPSASTPHTNIASIEAIHDAPQYIPNVSWKKLPDYSPPLSTLPTDSNKSLKIEWKGSPMDLSTDPLRNELHPAELVLAQTLRLPCDLYLDSKRRLFLEKVYRLKKGLPFRRTDAQKACRIDVNKASRLFQAFEKVGWLQDSNFTKYL
What are the official names of this protein?
SWIRM domain-containing protein FUN19.
Protein: SEQA_HAMD5
Sequence: MKLIEVDEELYRYIAAHTQYIGESASEILRRMFSLTQKKQTEIKIKKTPKIHQSSVKATLFSRIQILNDILSSETYASKNKVIARFMLILSTLYDLDSKAFSVAAESLQGRKRAYFSGSKNFLLKNGTHTKPKQIPKTPYWVITNTNSERKRTMLKNMMIAMKFPNEIAKKVSQTI
What is the function of this protein?
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle.  Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins.  Repression is relieved when the region becomes fully methylated.
What are the official names of this protein?
Negative modulator of initiation of replication.
What is the protein family that this protein belongs to?
Belongs to the SeqA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HLDE_ERWT9
Sequence: MKITLPDFTRAGVLVVGDVMLDRYWYGPTNRISPEAPVPVVKVDSVEERPGGAANVAMNIASLGAKSRLVGLTGVDDAARALSAALSGVNVQCDFVSVATHPTITKLRVLSRNQQLIRLDFEEGFDGVDPEPMLERIQRSLPGIGALVLSDYAKGALATVETMIALARKAGVPVLVDPKGTDFSRYHGATLLTPNLSEFEAVVGKCKSEADIVERGTALMQQHALSALLVTRSEHGMTLLQPGKAPFHMPTQAQEVFDVTGAGDTVIGVLATALAAGNTLEESCFLANAAAGVVVGKLGTSTVSPMELENAIHARPESGFGVMSEAQLIVEVKKARQRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTRRLKGETRPVNPLLNRMMVLGALEAVDWVIGFEEDTPQRAIAEILPDLLVKGGDYKPEDIAGSKEVWANGGDVQVLNFEDGISTSNIIKTIISGSGKN
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: YBT1_CANGA
Sequence: MVVEAMSSCQFWYFDDITKYGRIEVLNNYVPTTLVTISILILLHNFFIRFYKYDIKKETPTPSLSLKLSSLNLSESDEEMPLTMHAQHNYGSHPSPSELNTDSSALYDRHFSINNIDSGEVNDPTKYHLIKRNMFEKFRVVIEFVIVAFQLLLHCYLSIEKSNLNGDLQKFHFKPHVLLWTILFTLATLRVLNLNQNNKFVNKYSGNIWLVSFANYTVIFLAHILPFRSALIGHVNDYGSSQYYKSQFWLNLVLMALLLTSPIGNNLPVLYQPQQDRAPSPEPYVSLLTFFSFHWVQPFINKAYKNNSLSHSDLWSLKLEDYSINVMKSFLEFRNRPSMRSSRFGISLLRYFLNLFMFQWCFTTISAFSIFVPTILLKKLLDFIEHKDKGSMNLAWFYVFGMFISRFIVAICDHCNLFLGRRVCVRMKSIIISEIYSKALKRKITKQSKPADENNENDMIKHDEVSPQEVNDTTHVNADEESYSSNLGSIINLMSVDAFKISELCAYLHYFLETAIMLTVSLILLYKVIGTAAFVGILITIIIIPINSKLYAVVGTLQAGNLACTDKRVEKLNESFQAIRIIKYFSWEDKFKEGIMLVREKELALLLKRCMVWCVLAFSWFITPTLITGCTFAYSILIEKKQLTTPVAFTALSLFTLLRDPLDRISDMLSYLIQSKISLDRVQRFLETEETDKYDQLTVDKNGKRLAFENVTLRWDSDKDSFVLRNLDIEFMTGKLNVIVGATGSGKTSILMGLLGEMQLSEGKIIVPSLSPRHEYQSQAGVINDSIAYCSQAAWLLNDTVRNNILFNAPFDQARYDAVVEACSLKRDFQILKAGDSTEIGEKGITLSGGQKQRVSLARALYSSAGHLLLDDCLSAVDSHTALWIYDKCISGPLMEGRTCILVTHNIALTMKNADFVVMIEDGKVKEKGTPIELLAKGLLGEDENMKKSIISRSASSASLKGKSERSLGTTPAPVEIVQDSTPVNDDGKLIEEEGKAMGFVGKEIYKWYIKMYGGWYTIVALASVFTAILCLQITQAWWIRNWTVKRFSDVDESNYNLPASTFIVESRNRVLLTNEAGKKESENQNAGIAKFLVVYCLIGVMSSIIGSIKTFVNSLFGIRASKLIFDSLLDRVLHARVRFFDSTPIGRIMNRFSKDIESIDQEIPPNIQSVFYSAIEVFATLLLISYITPAFFPVAIIIVLGYSIVGFFYLTTSRELKRLDSISKSPIFQHFSETLVGVTTIRAFGDEQRFIKENLSMIDQNSMPFFYLWVVNRWLSFRIDLIGALVIFSSGVFILLNINNIDAGLAGISLTYAISFTEAALWLVRQYSELEMNMNSVERVLEYMNIEQEPLIADPANAVTPPPQWPDSGKVEVNNLSLKYAPHLPYVIKDVTFTIEPLEKVGIVGRTGAGKSTIITALFRFLEADTGSIKLDGVNIANIDLKRLRRSITIIPQDPTLFAGSIRSNLDPYDEYSDEEIFTALKRVNLVSTEEMEASTSEIQSNSSKNVNKFLNLESEIAEGGSNFSQGQRQLMCLARSLLRMPKVILLDEATASIDYNSDAKIQETIRQEFNNSTVLTIAHRLRSIVDYDKILVMDAGEVKEFDHPYSLLLEKKSIFYNMCEDSGELDVLIDLAKKSFISRLNSDSKK
What is the function of this protein?
Pleiotropic ABC efflux transporter that might be involved in the resistance to azoles such as fluconazole.
What are the official names of this protein?
Pleiotropic ABC efflux transporter of multiple drugs YBT1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BIOB_BACC7
Sequence: MKQVQTKRDWKKLAYDVVEEKVITKEDAIAILEADDTEILEIMNAAYIIRHHHFGKKVKLNMIINTKSGLCPEDCGYCSQSIISEAPIDKYAWLTQEKIVEGAHEAIRRKAGTYCIVASGRRPTDKEVNHVIGAVKEIRETTDLKICCCLGFLNEDQAGRLAEAGVHRYNHNLNTHANNYESICSTHTYDDRVDTVQKAKQAGISPCSGAIFGMGETIEERAEIAFELQRIDADSIPCNFLVAVKGTPLEGQKELTPVECLKVLAMMRFVNPTKEIRISGGREINLRSVQPIGLFAANSIFVGDYLTTAGQEPTADWGMIEDLGFEIEECAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: DNAK_STAAM
Sequence: MSKIIGIDLGTTNSCVTVLEGDEPKVIQNPEGSRTTPSVVAFKNGETQVGEVAKRQAITNPNTVQSIKRHMGTDYKVDIEGKSYTPQEISAMILQNLKNTAESYLGEKVDKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDKDEKVLVFDLGGGTFDVSILELGDGVFEVLSTAGDNKLGGDDFDQVIIDYLVAEFKKENGVDLSQDKMALQRLKDAAEKAKKDLSGVSQTQISLPFISAGENGPLHLEVNLTRSKFEELSDSLIRRTMEPTRQAMKDAGLTNSDIDEVILVGGSTRIPAVQEAVKKEIGKEPNKGVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIEILGGRMNTLIERNTTIPTSKSQIYSTAVDNQPSVDVHVLQGERPMAADNKTLGRFQLTDIPPAERGKPQIEVTFDIDKNGIVNVTAKDLGTNKEQRITIQSSSSLSDEEIDRMVKDAEVNAEADKKRREEVDLRNEADSLVFQVEKTLTDLGENIGEEDKKSAEEKKDALKTALEGQDIEDIKSKKEELEKVIQELSAKVYEQAAQQQQQAQGANAGQNNDSTVEDAEFKEVKDDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: DNAK_OLEA2
Sequence: MGKIIGIDLGTTNSCVYIMEGKDPKCITNPEGGRTTPSVVGFTDKERLVGDIAKRQAVTNPERTVFAIKRLMGRKADAPEVARWKEHSPYQIVAGPNGDAYVEIEGRKYSPAEVSAMVLAKLKADAEAYLGETVTEAVITVPAYFNDSQRQSTKDAGRIAGLDVKRIINEPTAASLAYGFDKKANEKIAVFDLGGGTFDISILEVGDNVVEVRATNGDTFLGGEDFDQRVINYLVEEFRRENGIDLSRDRMALQRLKEAAEKAKKDLSTSMETEINLPFITADQTGPKHLMIKLSRAKLEKLVEDLVERTIEPCRKALSDAGLSASEVDEVVLVGGMTRMPLVQKKVADFFGKEPNRSMNPDEVVSMGAAIQGGILAGDVKDVLLLDVTPLSLGIETLGGVFTRLIERNTTIPTKKSQTFTTAADNQPSVSIHVMQGERPMASDNMTLGRFELTGIPAAPRGMPQIEVSFDIDANGIVNVSAKDLGTGKEQSIRITASSGLSEDEIQNLVKEAEAHADEDKKKKELIEARNQADSLIYTTEKSLSDLGDKLEADLKKEIEDKTAALKTAMEGSDVDAIKKATDELSQASHKLAEKLYAQQQAGAQGAAGAEAGAGDAGAKASQDEDVVDADYTEVKN
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MURI_MYCMM
Sequence: MSSPLAPVGIFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYGPLTIPEVRAHALAIGDDLVGRGVKALVIACNTASAACLRDARERYDVPVVEVILPAVRRAVATTRNGRIGVIGTRATITSHAYQDAFAAARDTEITAVACPRFVDFVERGVTSGRQVLGLAEGYLEPLQRSGVDTLVLGCTHYPLLSGLIQLVMGDNVTLVSSAEETAKEVLRVLTERDILRPHDAPPATRLFEATGDPEAFMALAARFLGPALTGVQPVRPSGMH
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: RLMI_ECODH
Sequence: MSVRLVLAKGREKSLLRRHPWVFSGAVARMEGKASLGETIDIVDHQGKWLARGAYSPASQIRARVWTFDPSESIDIAFFSRRLQQAQKWRDWLAQKDGLDSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALISALQTLYPECSIYDRSDVAVRKKEGMELTQGPVTGELPPALLPIEEHGMKLLVDIQHGHKTGYYLDQRDSRLATRRYVENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQLLNEGGILLTFSCSGLMTSDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVM
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_LEUCK
Sequence: MATPSNKNSKSHKRNRRGHIGLNVPNIVLDKTTGEYRVAHRVSPSGVYNGKQVIEK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: YR368_MIMIV
Sequence: MSPEQWGIYGWTFSHAVALGYPINPTEEDKLRYYTFFNSYRYVLPCGKCRINYADHLNKYPLTDEVLSSRENLVKWTIDIHNVVNYYTGKKMLTYPEAIEAIEKTLTPKKKSSYNWFFIILIIIGIIVIIYLMYIVFKKKLNK
What is the function of this protein?
FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation.
What are the official names of this protein?
Probable FAD-linked sulfhydryl oxidase R368.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: S22A2_PONAB
Sequence: MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFTPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCGRYEVDWNQSAFGCVDPLASLDTNRSRLPLGPCREGWVYETPGSSIVTEFNLVCANSWMLDLFQASVNVGFFFGSVSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVTLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQCLRLEEETGEKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIIVTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVRLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN
What is the function of this protein?
Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics.  Functions as a Na(+)-independent, bidirectional uniporter.  Cation cellular uptake or release is driven by the electrochemical potential, i. e.  membrane potential and concentration gradient (By similarity).  However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity).  Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow.  Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters.  Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system.  Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium.  Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN).  Mediates the uptake and efflux of quaternary ammonium compound choline.  Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine.  Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha).  Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP).  May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity).
What are the official names of this protein?
Solute carrier family 22 member 2, Organic cation transporter 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MSCL_SHEON
Sequence: MSLIQEFKAFASRGNVIDMAVGIIIGAAFGKIVSSFVADIIMPPIGIILGGVNFSDLSVVLLAAQGDAPAVVIAYGKFIQTVIDFTIIAFAIFMGLKAINSLKRKQEEAPPASPAPTKDQELLSEIRDLLKAQQEK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YGDD_ECOL6
Sequence: MTSRFMLIFAAISGFIFVALGAFGAHVLSKTMGAVEMGWIQTGLEYQAFHTLAILGLAVAMQRRISIWFYWSSVFLALGTVLFSGSLYCLALSHLRLWAFVTPVGGVSFLAGWALMLVGAIRLKRKGVSHE
What are the official names of this protein?
UPF0382 inner membrane protein YgdD.
What is the protein family that this protein belongs to?
Belongs to the UPF0382 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y431_PECCP
Sequence: MERFIENLMYTSRWLLAPVYLGLSLGLLALAIKFFQEVFHVLPNIFDIAEADLVLVLLSLIDMTLVGGLLVMVMLSGYENFVSALDITDGREKLNWLGKMDSGSLKNKVAASIVAISSIHLLRVFMDARNIPDNKLMWYVIIHLTFVLSALVMGYLDRMSRYEKSKAA
What are the official names of this protein?
UPF0114 protein PC1_0431.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRPD_DINSH
Sequence: MSDALKPLIGAAADRPLTRAEAEAAFEILFEGEATPSQMGGLLMALRTRGETVAEYAAAAAVMRAKCNAVRAPEGAMDIVGTGGDGKGTLNISTATAFVVAGAGVPVAKHGNRNLSSKSGAADALAQMGIEVMVGPAVVERALSEIGIAFMMAPMHHPAIRHVMPTRAELGTRTMFNILGPLTNPAGVKRQLTGAFSRDLIRPMAETLAALGSDVAWLVHGSDGTDELTITGVSWVAGLSDGAVTEFEVHPEEAGLPVHPFEAILGGTPEENGAAFRALLAGEASAYRDAVLLNAAAALKVAGRVTALPDGVMLAAEAIDSGAALAKVQGLAQITSEAT
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RUVA_CUTAK
Sequence: MISHFSGTVSAAGPTWVVLDNHGVGIKVLCPPATAASARINQDMSLHTSLVVREESLTLYGFVEADDRDAFELVQTASGVGPKLAAAIMSVLDAAQLATAITEEDDATLCRVPGIGRKGAAKMILELKDKVAALAPRGASASGATHVAAPWREQVAEGLVGLGWSTKDAEKAVDKVVALKEADPAMSIGNLMRAALRSLAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ACPS_POLAQ
Sequence: MIIGIGTDILQIERLQAAYDRTNGRLAEKVLGPDEMLVFKHRLARNHKRGIAFLATRFAAKEAFSKAIGLGMHMPMTWRSLQTLNEPSGKPITSYLGALAQFMAEKNWEAHITVSDEQDMAIAHVIVTQK
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_CLOBK
Sequence: MDYKNLVAERIKENTELEVDLIEKLIEIPPKKEMGDYAFPCFQLAKTFRKAPNLIAEELKEKINKEGFEKVVTVGPYLNFFVDKTILIKDVLEKVLSEKEKYGSSKVGEGKNVVVEYSSPNIAKPFHIGHLFTTAIGNALYKILSFEGYNCIGINHLGDWGTQFGKLISAYRRWVDEEALEKDAIGELLRIYVKFHEEAEKDPELEKEARLNFKRLEDGSEEETELWNRFKDLSLKEFNKVYDMLGIKFDSLAGESFYSDKMDAVVQEIDDKGLLVDSNGAKVVMLDEYNMPPCMIKKSDGATIYATRDLAAAIYRKKTYDFHKCIYVVGTPQALHFKQVFTTLKLMGHDWADDCKHVGFGLVKLANKKLSTRNGDVVFLEDLLNQSVEETLKIINEKNPNLKNKEDVAKKLGIGAVVFTYLKNNRERDIVFDWKEILSFDGETGPYVEYSYARGKSILRKAGELTGEADYSKLSSKEEFELAKLLGGFNDAIMNAIDKLEPAMVTRYIIEVAKAFNKFYNAHGILNAEDNDVKLARVKLVEATCQVIKNALNLLGIDVVEEM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GTHB2_CORAU
Sequence: MLGLHVGTLMISLFLCILLEPVEGSLMQPCQPINQTVSLEKEGCPTCLVIQTPICSGHCFTKELVFKSPFSTVYQHVCTYRDVRYETICLPDCSPWVDPHVTYPVALSCDCSLCNMDTSDCTIESLQPDLCMTQRVLADGMW
What is the function of this protein?
Involved in gametogenesis and steroidogenesis.
What are the official names of this protein?
Gonadotropin subunit beta-2, GTH-II-beta, Gonadotropin beta-II chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: SUMO1_CERNI
Sequence: MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYHEQTGGHSTV
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2.  Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1.  Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.  May also regulate a network of genes involved in palate development.  Covalently attached to ZFHX3.
What are the official names of this protein?
Small ubiquitin-related modifier 1, SUMO-1, Sentrin.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane. Nucleus. Note=Recruited by BCL11A into the nuclear body (By similarity). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (By similarity).
Protein: NUP37_CHATD
Sequence: MALQPVPRMRRTLQNTQHTYSLGRRIYDVKTYPVQSPQGATILIYGHENGATVVWRGGRRLKPPKPQTNEKRNGTKPEDAVMIIDSDDETGPTFVDKPEFEDSPSVADGSVAEIIQTLDLALGTAVNHIAVLPMPPCAAEDASWNGANILKTKIVFAVTCATNDVYVITLPLTPPSHEAKARPELRKSLLAGNAGKGVWGETLTLLTGPSRSCNGVAISLVKHRSSSRSRSSERSAAQAAPITRVVVAAHSREASGTLRLWDVPLEAKPGTINRVEPFQTEYLPSPLTSISFNPVNLTQLLTVASPHAVRIYDYATASLPSDDTSEGPFPSQGSWLISLYPPFARGPAMSTSRKPIVAAEWIARGRAILTLLADGQWGIWDLDGASPTAAGGGSNLFSKTSAGLRGTAITAFSVTGHLEGTSPLRNPTTQKASSSSSGEFVPMTPHTRRDAIATAFGGSPEKLAAVRGGITVAQLPSTLTSGAGDESAVLFLGGADPIVCVIPVLSKFWDSQLRRAAGGGVNLWSGAQPTRMIRLTDLSAGLLGERCTGAVAITKAVRANASTNGILKEDDNSGSQGLPIEVLLQGESRLVIVHENGDAPTSSLTSRLLGARKKQRDEFKSVNAIVAYPPLEKPSVSFNLNLTQRPEKPGTLFAPRSRHSKSLFEQSIDTIPSTDAGDEETIPATSAPSSQQGFMFATDLELAADLPDDEADAEGRDVEQELLDIMEIDRELEQLEQARERGRKRVFFEEG
What are the official names of this protein?
Nucleoporin NUP37, Nuclear pore protein NUP37.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex.
Protein: GRPE_CHESB
Sequence: MNDGFAMNTHSKDERAPENGQAENMAVENGAEAAQAADRATPVSEEDVLLRLAKENEDLKERALRLTAEMENLRKRTQRDVADARVYGIANFARDMLTVSDNLQRALQAVSEEARAQADSGLKALVEGVEMTERAMLATLERHGVKRVDPNGEKFDPHFHQAMFEVPNADVPNNTVVQVVQPGYVIGDRVLRPAMVGVAKGGPKAETPAATSEQAAQGPEGA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.