PharMolix/UniProtQA huggingface dataset:
Protein: RSMH_BRUME
Sequence: MASLGGDNSQAEGAEVRHVPVLIAEVIDALKPAPGAVIVDGTFGAGGYTRRILETGADVIAIDRDPTAIEAGRAMEKEFPGRLNLVESRFSALDEAVARMSGAGKKVDGVVLDIGVSSMQIDEAERGFSFQKDGPLDMRMSSRGPSAADAVNRLKTGDLARIFNFLGEERHAGRIARMIEKRRAAKPFTRTLDLANAIETLVGRNPKDRIHPATRVFQALRVYVNDELGELARALLAAERILKPGGRLVVVTFHSLEDRMVKRFFADRAGGSAGSRHMPETHMRLPSFTPAVKGAVGPTPEEEERNPRARSAKLRAGIRTENPPLEDDLSLFGLPKLPETNELARS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MERB_STAES
Sequence: MKNISEFSAQLNQTFDQGEAVSMEWLFRPLLKMLAEGDPVPVEDIAAETGKPVEEVKQVLQTLPSVELDEQGRVVGYGLTLVPTPHRFEVDGKQLYAWCALDTLMFPALIGRTVHIASPCHGTGKSVRLTVEPDRVVSVEPSTAVVSIVTPDEMASVRSAFCNNVHFFSSPSAAQDWLNQHPESSVLPVEDAFELGRHLGARYEESGPTNGSCCNI
What is the function of this protein?
Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate.  One product is Hg(2+), which is subsequently detoxified by the mercuric reductase (By similarity).
What are the official names of this protein?
Alkylmercury lyase, Organomercurial lyase.
What is the protein family that this protein belongs to?
Belongs to the MerB family.
Protein: MOTA_TREPH
Sequence: MDLASFIGFFGAFAIILMGGILGGSASGFFHLPSVFITVGGSYLTLFLAYPLSYTLGIFKVCARVFKSADFHEKEIVQRLYALAEKSRRTGLLALEEEIQDFDDEFMRTGLRNVVDGIDGEAIRNLMENELSHMEERHNRWISFINAWATLAPGYGMLGTVMGLIGMLMALEDKSSLGQNMAVALVTTLYGSLMANWLLIPMATKLGLQHEAEVKSKEMIIEGVLAIQAGDHPRILAQRLLVYLNPKDKRELEAELIKD
What is the function of this protein?
MotA and MotB comprise the stator element of the flagellar motor complex.  Required for rotation of the flagellar motor.  Probable transmembrane proton channel (By similarity).
What are the official names of this protein?
Motility protein A, Chemotaxis protein MotA.
What is the protein family that this protein belongs to?
Belongs to the MotA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GATB_LEGPA
Sequence: MEWDTVIGLEVHAQLKTKSKLFSGASTAFGATPNSQTSFIDAGLPGVLPVLNEQAIIMAIQFGLAIHGTINDLSVFERKNYFYPDLPKGYQISQYQKPIVTNGYLNIQLGNNLEKTVHIARAHLEEDAGKSLHDAHTDYTGIDLNRAGTPLLEIVTTPCLYSAEEAVNYLKTLHQLVRFLGICDGNMQEGSFRCDVNLSIKPKGSSVLGTRTELKNLNSFRFIEKAIAFEQARHQDILERGLSVIQETRLYNPDNNTTQAMRGKENENDYRYFPDPDLLPIDIDKEQIEEIKNNLPDLPEAIYKELKNTPSLNDEDINFILSSPDTYQYYKKIKSLCPAADKTIINWLKGQYAAFLNEHNLTFETPPISAKTMAAFLSKIHEKKISSSIAKNIFSMLCAGEEDIDAIIEREGYQQQNDNSALEEIVEQIIKQYPEQVIEYKAGKEKLLAFFIGQAMKQTKGKANPEQINLLLKKHLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: LRC51_MOUSE
Sequence: MSSRDYMNTSVQEPPLDYSFKSVQMVQDLVTEEPRTGLRPVRHSKSGKSLTQSLWLNNNVLNDLKDFNQVVSQLLQHPENLAWIDLSFNDLTTIDPVLTTFFNLSVLYLHGNGIHRLGEVNKLAVLPRLRSLTLHGNPIEEEKGYRQYVLCNLPRITTFDFSGVTRADRSTAEVWKRMGIKPKKVRAKQDVL
What are the official names of this protein?
Leucine-rich repeat-containing protein 51.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBZ_GUITH
Sequence: MVTILQLLVSILILLSFALVVGVPVILVSPGEWERSKNLVYASAGLWFGLVIVTAAFNSFVI
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: S35B1_DICDI
Sequence: MSLTKKIKNEKSLKQEKQTDQLKSNLRNNNNNINNKSKPKDQNLNTLHYIKTHLKEELFFIFCVGGIYIFYLLYGLVQEQLNVTKFGTEKKVFGFTAFLLALQCFFNMVSAWLVSLVNKEQKDNTPFMKYGFVSMLLVISTFLSNQSIRYISYPTQVLAKSCKPIPVIFMGLLLFKKKYPFLKYIVVIVISLGISLFMLPKATSKKNIQFEGHDHLFGNFILFVSLMMDGVMGPFQDNLVRQYKPSATSMMLNTNIWNLGLFSIMAFARGEVSQAIDFILEYPEVIKLILAFCITSAIGQQFIFLTTNKFGSLNCSTITTTRKFFSILVSIFYFGHSLDNLQWAAICMVFGGLILDLYISYSNKKKGVVLSPIAAPVKHPTATTPLENKKSL
What is the function of this protein?
Probable sugar transporter.
What are the official names of this protein?
Solute carrier family 35 member B1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PCOE_ECOLX
Sequence: MKKILVSFVAIMAVASSAMAAETMNMHDQVNNAQAPAHQMQSSAEKSAVQGDSMTMMDMSSHDQAAMSHDMMQNGNSAAHQDMAEMHKKMMKSKPAASNETAKSFSEMNEHEKSAVVHEKANNGQSSVIHQQQAEKHRSQITQN
What is the function of this protein?
Required for the copper-inducible expression of copper resistance.  Activated by the two-component regulatory system CusS/CusR.
What are the official names of this protein?
Probable copper-binding protein PcoE.
What is the protein family that this protein belongs to?
To S.typhimurium SilE.
What are the subcellular locations of this protein?
Periplasm.
Protein: EFTS_LACDB
Sequence: MANITAKQVKELRETTGAGVMDAKKALVEAEGDMQRAIEIIHEKGEAKAAKKANRIAAEGLTGVYVDGNVAAIVEVNAETDFVAQNEQFKTLVNETAETIAKGKPANNEEALALTMPSGESLEEAYVNATATIGEKISFRRFAVLEKTDDQHFGAYQHNGGHIGVLTVVEGGDEALAKHIAMHIAAMSPKVLSYKELDPAFVREELAQLNHKIDQDNESRAMVNKPALPHLKYGSKAQLTDEVIAQAEEDIKAELKAEGKPEKIWDKIIPGKMARFMLDNTKVDQENTLLAQLYVMDDSKTVEQYLESVNASVVSFVRFEVGEGIEKKQEDFAAEVAAQMKN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETD_PINTH
Sequence: MGVTKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLSYIFPVVILGTIACTIGLAVLEPSMIGEPANPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMGSVPAGSLTVPFLENVNQFQNPFRRPVATTVSLIGTAVALWLGIGAALPIDESLTLGLFQSNLIQLSNIKIFQFFYSYI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MYG_BALAC
Sequence: MVLSDAEWHLVLNIWAKVEADVAGHGQDILIRLFKGHPETLEKFDKFKHLKTEAEMKASEDLKKHGNTVLTALGGILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISDAIIHVLHSRHPAEFGADAQAAMNKALELFRKDIAAKYKELGFQG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SFSA_NITOC
Sequence: MSFDQILLPGILRRRYQRFFADVALETGESIVAHCPNTGSMRGLAEPGLGVYVSRANNPRRKLAYTLELVDAHTSLVGVHTGRANILTKEAIAAGRISQLLGYGEIRQEVRYSKNSRIDLLLEDPSTQQCCYVEVKSVTLRQGDGAACFPDAVTTRGAKHLDDLAATVCSPRQRAVMFYLVQREDCRYFTPADDIDPRYGAKLRSAIEQGVEILAYACQVSSQGIQVTQSLPIHL
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: DAPA_STRPI
Sequence: MSYQDLKKCKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDGILLAGTTAESPTLTHDEELELFAAVQKVVNGRVPLIAGVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQEGMYQHFKTIADASDLPIIIYNIPGRVVVELTPETMLRLADHPNIIGVKECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFTAIAESDMKKAAAIQRKFIPKVNALFSYPSPAPVKAILNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAHM1_MOUSE
Sequence: MDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCLPGYNVVYSLGILLTPPLVLFLLGLVMNNNISMLAEEWKRPAGRRAKDPAVLRYMFCSMAQRALIAPVVWVAVTLLDGKCFLCAFCTAVPVATLGNGSLVPGLPAPELARLLARVPCPEIYDGNWLLAREVAVRYLRCISQALGWSFVLLTTLLAFVVRSVRPCFTQVAFLKSKYWSHYIDIERKLFDETCTEHAKAFAKVCIQQFFEAMNHDLELGHTHGVLATATATATATEAVQSPSDRTEEEREKLRGITDQGTMNRLLTSWHKCKPPLRLGQEAPLMSNGWAGGEPRPPRKEVATYFSKV
What is the function of this protein?
Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP, required for sensory perception of sweet, bitter and umami tastes (PubMed:23467090).  Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (PubMed:23467090).  Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (PubMed:29681531).  Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration (PubMed:22711817).  Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions (PubMed:22711817).  Acts as an activator of the ERK1 and ERK2 cascade (By similarity).  Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (By similarity).  May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (By similarity).
What are the official names of this protein?
Calcium homeostasis modulator protein 1.
What is the protein family that this protein belongs to?
Belongs to the CALHM family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane of epithelial cells including taste cells (PubMed:30804437). Colocalizes with HSPA5 at the endoplasmic reticulum (By similarity).
Protein: MNHD2_STAA1
Sequence: MLSNLLILPMLLPFLCALILVFLKNNDRISKYLYLGTMTITTIISLMLLIYVQRHRPITLDFGGWSAPFGIQFLGDSLSLIMVTTASFVITLIMAYGFGRGEHKANRYHLPSFILFLSVGVIGSFLTSDLFNLYVMFEIMLLASFVLITLGQSVEQLRAAIIYVVLNIIGSWLFLLGIGLLYKTVGTLNFSHIAMRLNDMGDNRTVTMISLIFLVAFSAKAALVLFMWLPKAYAVLNTELAALFAALMTKVGAYALIRFFTLLFDQHNDLIHPLLATMAAITMVIGAIGVIAYKDIKKIAAYQVIISIGFIILGLGTNTFAGINGAIFYLVNDIVVKTLLFFIIGSLVYITGYRQYQYLNGLAKKEPLFGVAFIIMIFAIGGVPPFSGFPGKVLIFQGALQNGNYIGLALMIITSLIAMYSLFRIFFYMYFGDKDGEEVNFKKIPLYRKRILSILVVVVIAIGIAAPVVLNVTSDATELNTSDQLYQKLVNPHLKGED
What are the official names of this protein?
Putative antiporter subunit mnhD2, Mrp complex subunit D2, Putative NADH-ubiquinone oxidoreductase subunit mnhD2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LOLD_SALCH
Sequence: MNKILLQCDNLCKRYQEGTVQTDVLHDISFSIGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFSGQPMSKLSSAAKAELRNQKLGFIYQFHHLLPDFTALENVAMPLLIGKKKPAEIDARAREMLHAVGLEHRATHRPSELSGGERQRVAIARALVNNPRLVLADEPTGNLDARNADSIFELLGELNRLQGTAFLVVTHDLQLAKRMSRQLEMRDGRLTAELSLMGAE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RISB_YERE8
Sequence: MNVIEGVVATPNARVAIAIARFNNFINDSLLEGAIDALKRIGQVTDDNITVVWVPGAYELPLVANVLAKTNRYDAVIALGTVIRGGTAHFEYVAGEASSGLSSVAMNSDIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVIKAIKG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: LPXD_BORPD
Sequence: MPILLDPVRAPALDALLASANTQGLDWRIEAAADATLPRIRGIGTLASAGPEEISFLTNPRYQSQLAGTRAAAVIVTPDAAQALANDPSAPACARVVCPHPYLLYARLAQWFDAARRPRLPASVHPLAVVAPDAVIEDDVRIGPHCVVEAGASIGRGSTLGPGCVIGEGSSLGPDCLLHARVTLYANVRIGARAILHSGVVLGADGFGFAPDPTLGQGAWGKIAQLGGVRIGDDVEIGANTTIDRGALEDTDIGDGVKLDNQIMLGHNVRVGAHTAMAACVGVAGSTVIGSRCTIGGAAMLSGHLTLGDDVHISGGTAVTSNILQPGRYTGVYPYAEHGEWQRNAAVLQQLSQLRRRLRALEKA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: NDBX_MESMA
Sequence: MKPRVFFLLFLLVAAMIETGESEENEEGSNESGKSTEAKNTDASVDNEDSDIDGDSD
What are the official names of this protein?
Peptide BmKa1, Acidic venom peptide Ka1, BmK2, Non-disulfide-bridged peptide 6.1, NDBP-6.1.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPX_ACTSZ
Sequence: MTDEKETRCSFCGKSQDEVGKLIAGTSGYICGDCIDLCHTLLHEEIEAEEDESADEIEEKLPTPHEIREHLDDYVIGQDYAKKVLAVALYNHYKRLRSGHKTDAVELSKSNVLLIGPTGSGKTLLAQTLARMLNVPFAMADATTLTEAGYVGEDVENIIQKLLQNCDYDTEKAEQGIIYIDEIDKITRKSANPSITRDVSGEGVQQALLKMIEGTIAAVPPQGGRKHPQQDMIRVDTSKILFICGGAFAGLDKIIEKRVHVGSGIGFNAEVKGEQDELTLTDLFKQIETEDLIKFGMIPEFIGRLPVIAPLSELDENALISILTEPKNALTKQYQALFGLEDVELEFTPESLKAMAKKALARKTGARGLRSIVEGILLDTMYDLPSQENLAKVIVDEDVIEKGEKPKLIFK
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RS21_CLOBK
Sequence: MSEIKVGENESLENALRRFKKKCARAGVLSEVRKREHYEKPSVKKKKKSEAARKRKFK
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: TSAC_SHIBS
Sequence: MNNNLQGDAIAAAIDVLNEERVIAYPTEAVFGVGCDPDSETAVMRLLELKQRPVDKGLILIAANYEQLKPYIDDTMLTDAQRETIFSRWPGPVTFVFPAPATTPRWLTGRFDSLAVRVTDHPLVVALCQAYGKPLVSTSANLSGLPPCRTVDEVRAQFGAAFPVVLGETGGRLNPSEIRDALTGELFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KRA93_MOUSE
Sequence: MACCATSFCGFPTCSTGGSSCCQPTCTQSSCCQPSCCEASCCQPSCCETGFGGGIGCGQEGGSGGVSCRVRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCQPSCSEPSC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
What are the official names of this protein?
Keratin-associated protein 9-3, Keratin-associated protein 9.3, Ultrahigh sulfur keratin-associated protein 9.3.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 9 family.
Protein: DDL_DESVV
Sequence: MKVLLIAGGWSSERDVSLAGARGIEKALRALGHDVTWFDPATSLDGLLEAASSHDFAFINLHGSPGEDGLVQAMLDTAGCPYQGSGPAGSFLALNKAVSKQLLRRHGILTPDWAFLAARPAADWEPGLGYPLFVKPNTGGSSLCLSRVTQPEGLAPALEAVFAHCGEAIVEPAIPGVEVTCGVLGDTALPPILIRPAEGAFFDYTSKYTPGGATELCPAPLPAEVTAHVQDVTLRAHRLLGLRGYSRADYILRDDGALFLLEVNTLPGMTPTSLVPQEAAAIGLDFPALIARLIELGMTAAGR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG4_NEUCR
Sequence: MTSSRPSGRDSTGWQETVSNTSPKLVNAMEAARAGAAEVGRVGRRFLYRIWDWEPVNNRTINEPVWCLGCSYTLDIKQYGSPLSSSSLSQLTADTPPLDKSQLAATHQHQDFNGVRTTATATCLSDTSMSAAPTGSQLGSFDTVPDSVTSGYDSALAYEEPGQDGGWPPAFLDDFESRIWMTYRTDFALIPRSSDPQASSALSFAMRIKTTFSDLTGFSSDTGWGCMIRSGQSLLANAILIARLGREWRRGTDLDAEKDIIALFADDPRAPYSLHNFVKYGATACGKYPGEWFGPSATARCIQALADEKQSGLRVYSTGDLPDVYEDSFMAVANPDGRGFQPTLILVCTRLGIDKINQVYEEALISTLQLPQSIGIAGGRPSSSHYFVGVQGQRLFYLDPHHPRPALPYREDPRGYTAEELDTCHTRRLRQLHIGDMDPSMLIGFLIKDEDDWDTWKSSVKHVQGKSIISVSPYDPARGQGGGRAEAIDEVETLESDDDGEPALGA
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Cysteine protease 1, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: NIFN_HERSE
Sequence: MPSASLLKAAAVNALKMSQVGRGLCLPGMNRYMPVMHGAQGCTSFGLVLLVRDFREAIPLQTTAMNEVSSTLGGMENIAKAVLNIRLRAKRDLIAICSTGLTETKGDDVNAYLRLTAEAPRPGRYLTGLCPHALTTGASQDGWAKALEALAGRWESRGRADARQADNLLAGCHLTPADIEEMRDIVQSFGLEPIVLPDVSSWLDGHLPDNFSPTSMGGTTLAEMRALGASIVCIANRRTEAPPTAQAVQELCGVPYVVFDRLTGLQANDRFLAYLEYVSGQPIPARYRRQRSQLQDAMLGWPLLLRPGVKVAIGAEPEPVAVTLRHGWPRWAAELGGCRDHHDLAGARWRSPQPGWWIGANLEAPGTKGARARACAGSCWLTHSHGGQAAERLHIPFHRAGLPPCSTGLGAGHCLSVGYRGTRGLIFEIGQPVAGRGPCTYPG
What is the function of this protein?
This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).
What are the official names of this protein?
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifN.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: HFQ_BRASB
Sequence: MAADRAQNLQDTFLNHVRKTKTPLTIFLVNGVKLQGIVTWFDNFCLLLRRDGHSQLVYKHAISTIMPGAPIQLFEGGEDASA
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: MQO_ACIB5
Sequence: MKKFLKYLLVLIILILIAGIVFLFRPIASKQVQTAKDEPVVDAVLVGGGIMSATLGTYFTELEPNWQIRMYERLDQVAQESSNGFNNAGTGHSGFMEMNYTEEKNGKMEIAKAEKVASQFEVAKQFWSYQVKQGVLAEPKTFINPVPHIAFVWGDNVKFLEKRYAAMIQSPLFKGMKFTEDPAVIKQWAPLVMTDRDPTQKVAATRMEVGSDVNYGSITKQLVNHLNQNPNFKLQTSTEVTGISQNDDKTWTVSFKNLKTGKTDHVKTRFVFIGAGGAAVKLLQLTGLPEAKQYAGFPVGGEFLITDNPAITAQHTAKVYGRAELGAPPMSVPHIDTRYIDGKKYVLFGPFATYSNKFLKNGSQLDLLASTNKSNVLPMTTVGLENLDLVKYLVSQVMMSDEDRLNELRKYYPDAKAEDWRLSQGGQRVQIIKKEPGKPATLQFGTEIFASKDGAVTALLGASPGASTSPYIMLNLLEKAFPQQTEGKWNQKLHEIVVSYKQDLSKDPVLLDKVRQYTSSTLGLNYTSPFKAANDETAAAPVAKAN
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: AROA_SYNY3
Sequence: MALLSLNNHQSHQRLTVNPPAQGVALTGRLRVPGDKSISHRALMLGAIATGETIIEGLLLGEDPRSTAHCFRAMGAEISELNSEKIIVQGRGLGQLQEPSTVLDAGNSGTTMRLMLGLLAGQKDCLFTVTGDDSLRHRPMSRVIQPLQQMGAKIWARSNGKFAPLAVQGSQLKPIHYHSPIASAQVKSCLLLAGLTTEGDTTVTEPALSRDHSERMLQAFGAKLTIDPVTHSVTVHGPAHLTGQRVVVPGDISSAAFWLVAASILPGSELLVENVGINPTRTGVLEVLAQMGADITPENERLVTGEPVADLRVRASHLQGCTFGGEIIPRLIDEIPILAVAAAFAEGTTRIEDAAELRVKESDRLAAIASELGKMGAKVTEFDDGLEIQGGSPLQGAEVDSLTDHRIAMALAIAALGSGGQTIINRAEAAAISYPEFFGTLGQVAQG
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.