Protein: POLG_ENMGO
Sequence: MATTMEQEICAHSMTFEECPKCSALQYRNGFYLLKYDEEWYPEELLTDGEDDVFDPDLDMEVVFETQGNSTSSDKNNSSSEGNEGVIINNFYSNQYQNSIDLSANATGSDPPKTYGQFSNLLSGAVNAFSNMLPLLADQNTEEMENLSDRVSQDTAGNTVTNTQSTVGRLVGYGTVHDGEHPASCADTASEKILAVERYYTFKVNDWTSTQKPFEYIRIPLPHVLSGEDGGVFGATLRRHYLVKTGWRVQVQCNASQFHAGSLLVFMAPEYPTLDVFAMDNRWSKDNLPNGTRTQTNRKGPFAMDHQNFWQWTLYPHQFLNLRTNTTVDLEVPYVNIAPTSSWTQHASWTLVIAVVAPLTYSTGASTSLDITASIQPVRPVFNGLRHEVLSRQSPIPVTIREHAGTWYSTLPDSTVPIYGKTPVAPANYMVGEYKDFLEIAQIPTFIGNKVPNAVPYIEASNTAVKTQPLAVYQVTLSCSCLANTFLAALSRNFAQYRGSLVYTFVFTGTAMMKGKFLIAYTPPGAGKPTSRDQAMQATYAIWDLGLNSSYSFTVPFISPTHFRMVGTDQANITNVDGWVTVWQLTPLTYPPGCPTSAKILTMVSAGKDFSLKMPISPAPWSPQGVENAEKGVTENTDATADFVAQPVYLPENQTKVAFFYDRSSPIGAFAVKSGSLESGFAPFSNKACPNSVILTPGPQFDPAYDQLRPQRLTEIWGNGNEETSEVFPLKTKQDYSFCLFSPFVYYKCDLEVTLSPHTSGAHGLLVRWCPTGTPTKPTTQVLHEVSSLSEGRTPQVYSAGPGTSNQISFVVPYNSPLSVLPAVWYNGHKRFDNTGDLGIAPNSDFGTLFFAGTKPDIKFTVYLRYKNMRVFCPRPTVFFPWPTSGDKIDMTPRAGVLMLESPNPLDVSKTYPTLHILLQFNHRGLEARIFRHGQLWAETHAEVVLRSKTKQISFLSNGSYPSMDATTPLNPWKSTYQAVLRAEPHRVTMDVYHKRIRPFRLPLVQKEWRTCEENVFGLYHVFETHYAGYFSDLLIHDVETNPGPFTFKPRQRPVFQTQGAAVSSMAQTLLPNDLASKAMGSAFTALLDANEDAQKAMKIIKTLSSLSDAWENVKGTLNNPEFWKQLLSRCVQLIAGMTIAVMHPDPLTLLCLGVLTAAEITSQTSLCEEIAAKFKTIFTTPPPRFPVISLFQQQSPLKQVNDVFSLAKNLDWAVKTVEKVVDWFGTWVAQEEREQTLDQLLQRFPEHAKRISDLRNGMAAYVECKESFDFFEKLYNQAVKEKRTGIAAVCEKFRQKHDHATARCEPVVIVLRGDAGQGKSLSSQIIAQAVSKTIFGRQSVYSLPPDSDFFDGYENQFAAIMDDLGQNPDGSDFTTFCQMVSTTNLLPNMASLERKGTPFTSQLVVATTNLPEFRPVTIAHYPAVERRITFDYSVSAGPVCSKTEAGCKVLDVERAFRPTGDAPLPCFQNNCLFLEKAGLQFRDNRSKEILSLVDVIERAVTRIERKKKVLTAVQTLVAQGPVDEVSFYSVVQQLKARQEATDEQLEELQEAFARVQERSSVFSDWMKISAMLCAATLALTQVVKMAKAVKQMVRPDLVRVQLDEQEQGPYNETTRIKPKTLQLLDVQGPNPTMDFEKFVAKFVTAPIGFVYPTGVSTQTCLLVKGRTLAVNRHMAESDWTSIVVRGVSHTRSSVKIIAIAKAGKETDVSFIRLSSGPLFRDNTSKFVKASDVLPHSSSPLIGIMNVDIPMMYTGTFLKAGVSVPVETGQTFNHCIHYKANTRKGWCGSAILADLGGSKKILGFHSAGSMGVAAASIISQEMIDAVVQAFEPQGALERLPDGPRIHVPRKTALRPTVARQVFQPAFAPAVLSKFDPRTDADVDEVAFSKHTSNQETLPPVFRMVAREYANRVFALLGRDNGRLSVKQALDGLEGMDPMDKNTSPGLPYTTLGMRRTDVVDWETATLIPFAAERLEKMNNKDFSDIVYQTFLKDELRPIEKVQAAKTRIVDVPPFEHCILGRQLLGKFASKFQTQPGLELGSAIGCDPDVHWTAFGVAMQGFERVYDVDYSNFDSTHSVAVFRLLAEEFFSEENGFDPLVKDYLESLAISKHAYEEKRYLITGGLPSGCAATSMLNTIMNNIIIRAGLYLTYKNFEFDDVKVLSYGDDLLVATNYQLNFDRVRTSLAKTGYKITPANKTSTFPLESTLEDVVFLKRKFKKEGPLYRPVMNREALEAMLSYYRPGTLSEKLTSITMLAVHSGKQEYDRLFAPFREVGVIVPTFESVEYRWRSLFW
What is the function of this protein?
Replicates the genomic and antigenomic RNAs by recognizing replications specific signals (Probable).  Performs VPg uridylylation (PubMed:24600002).
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the picornaviruses polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein VP2]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein VP3]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein VP1]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Protein 2A]: Host nucleus, host nucleolus. SUBCELLULAR LOCATION: [Protein 2B]: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are probably autophagosome-like vesicles. SUBCELLULAR LOCATION: [Protein 2C]: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are probably autophagosome-like vesicles. SUBCELLULAR LOCATION: [Protein 3A]: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are probably autophagosome-like vesicles. SUBCELLULAR LOCATION: [VPg]: Virion. SUBCELLULAR LOCATION: [Protease 3C]: Host cytoplasm. SUBCELLULAR LOCATION: [RNA-directed RNA polymerase]: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are probably autophagosome-like vesicles.