PharMolix/UniProtQA huggingface dataset:
Protein: ALBA_ASPNA
Sequence: MEGPSRVYLFGDQTSDIEAGLRRLLQAKNSTIVQSFFQQCFHAIRQEIAKLPPSHRKLFPRFTSIVDLLSRSRESGPSPVLESALTCIYQLGCFIHFYGDLGHDYPTPSNSHLVGLCTGVLSCTAVSCARNVGELIPAAVESVVIALRLGICVFRVRELVDSADSESTCWSALVSGISEAEASHLIDEYSSKKATPPSSKPYISAVSSNGVTVSAPPTVLDEFVETCISKNYKPVKAPIHGPYHAPHLYDDKDIDRILQQSSALEGLTGCSPVIPIISSNTGKPIKAKSIKDLFKVALEEILLRRLCWDKVTESCTSVCKTGTNHSCKLFPISSSATQSLFTVLKKAGVSISLETGVGEIATNPEMRNLTGKAENSKIAIIGMSGRFPDSDGTESFWNLLYKGLDVHRKVPADRWDVDAHVDMTGSKRNTSKVAYGCWINEPGLFDPRFFNMSPREALQADPAQRLALLTAYEALEMAGFIPDSSPSTQRDRVGIFYGMTSDDYREINSGQDIDTYFIPGGNRAFTPGRINYYFKFSGPSVSVDTACSSSLAAIHMACNSIWRNDCDAAITGGVNILTNPDNHAGLDRGHFLSTTGNCNTFDDGADGYCRADGVGSIVLKRLEDAEADNDPILAVINGAYTNHSAEAVSITRPHVGAQAFIFNKLLNDANIDPKDVSYVEMHGTGTQAGDAVEMQSVLDVFAPDYRRGPGQSLHIGSAKANIGHGESASGVTALVKVLLMMRENMIPPHCGIKTKINSNFPTDLAKRNVHIAFQPTPWNRPASGKRRTFVNNFSAAGGNTALLLEDAPIPERQGQDPRSFHLVSVSARSQSALKNNVEALVKYIDSQGKSFGVKETEFLPNLAYTTTARRIHHPFRVTAVGANLQSLRDSLHGALHRETYTPVPSTAPGIGFVFTGQGAQYSGMGKELYRSCFQFRTTIEHFDCIARSQGLPSILPLVDGSVAVEELSPVVVQVGTTCVQMALVNYWTALGVKPAFIIGHSLGDYAALNTAGVLSTSDTIYLCGRRAQLLTKECKIGTHSMLAIKASLAEVKHFLRDELHEVSCVNAPAETVVSGLVADIDELAQKCSTEGLKSTKLKVPYAFHSSQVDPILEAFEDIAQGVTFHKPTTPFVSALFGEVITDANWECLGPKYLRDHCRKTVNFLGGVEATRHAKLTNDKTLWVEIGSHTICSGMIKATLGPQVTTVASLRREEDTWKVLSNSLASLHLAGIDINWKQYHQDFSSSLQVLRLPAYKWDLKNYWIPYTNNFCLSKGAPVATVAAGPQHEYLTTAAQKVIETRSDGATATVVIENDIADPELNRVIQGHKVNGTALCPSSLYADISQTLAEYLIKKYKPEYDGLGLDVCEVTVPRPLIAKGGQQLFRVSATADWAEKKTTLQIYSVTAEGKKTADHATCTVRFFDCAAAEAEWKRVSYLVKRSIDRLHDIAENGDAHRLGRGMVYKLFAALVDYDDNFKSIREVILDSEQHEATARVKFQAPQGNFHRNPFWIDSFGHLSGFIMNASDATDSKNQVFVNHGWDSMRCLKKFSPDVTYRTYVRMQPWKDSIWAGDVYVFDGDDIVAVYGAVKFQALSRKILDTVLPPSRASAPAPAKPAAKPSAPSLVKRALTILAEEVGLSESEITDDLVFADYGVDSLLSLTVTGRYREELDIDLESSIFIDQPTVKDFKQFLAPMSQGEASDGSTSDPESSSSFNGGSSTDESSAGSPVSSPPNEKVTQVEQHATIKEIRAILADEIGVTEEELKDDENLGEMGMDSLLSLTVLGRIRETLDLDLPGEFFIENQTLNDVEDALGLKPKAAPAPAPAPAPVPAPVSAPILKEPVPNANSTIMARASPHPRSTSILLQGNPKTATKTLFLFPDGSGSATSYATIPGVSPDVCVYGLNCPYMKTPEKLKYPLAEMTFPYLAEIRRRQPKGPYNFGGWSAGGICAYDAARYLILEEGEQVDRLLLLDSPFPIGLEKLPTRLYGFINSMGLFGEGNKAPPAWLLPHFLAFIDSLDTYKAVPLPFDDPKWAKKMPKTFMVWAKDGICSKPDDPWPEPDPDGKPDTREMVWLLKNRTDMGPNKWDTLVGPQNVGGITVIEGANHFTMTLGPKAKELGSFIGNAMAN
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of aurasperone B, a dimeric gamma-naphthopyrone (PubMed:31067027).  The first step in the biosynthesis of aurasperone B is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase albA, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:31067027).  YWA1 is then methylated by aunE at position C-6 to yield foncesin which is further methylated at position C-8 by aunD to produce fonsecin B (Probable).  A key enzyme in the biosynthetic pathway is the cytochrome P450 monooxygenase aunB which catalyzes the oxidative dimerization of fonsecin B to aurasperone B (PubMed:31067027).  AunB also catalyzes the oxidative dimerization of rubrofusarin B into aurasperone A (PubMed:31067027).
What are the official names of this protein?
Non-reducing polyketide synthase albA, NR-PKS albA.
Protein: SERC_ECOSM
Sequence: MAQIFNFSSGPAMLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKEFIQVAEEAEKDFRDLLNVPSNYKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAASAIKEAKKYCTPNVFDAKVTVDGLRAVKPMREWQLSDNAAYMHYCPNETIDGIAIDETPDFGKDVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIACPSILDYSILNDNGSMFNTPPTFAWYLSGLVFKWLKANGGVAEMDKINQQKAELLYGVIDNSDFYRNDVAKANRSRMNVPFQLADSALDKLFLEESFAAGLHALKGHRVVGGMRASIYNAMPLEGVKALTDFMVEFERRHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSSS_STAA8
Sequence: MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTIDQKGHKTFYGEPFREDTLSQNAINNVLNNQDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIQVNQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSL
What is the function of this protein?
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence.  HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR.  HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
What are the official names of this protein?
Heme sensor protein HssS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL17_GLOC7
Sequence: MRHRCRVPQLGRPADQRKALLRALTTELIRHGQITTTLTRAKAVRSQADKMITLAKDGSLAARRQAMGYIYDKQLVHRLFDQAQERYSNRNGGYTRVVRTLRRRGDNAEMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: YCIB_YERPN
Sequence: MKQLLDFLPLVVFFIFYKMYDIFVASGALIVATLVALAFTWLKYRKVEKMTLVTAAMVLVFGTLTLAFHSDLFIKWKVTVLYVLFALALLVSQWVMKKPLIQRMLGKELTLPDKVWSTLNLSWAIFFLVCGLLNIYVAFWLPQDIWVNFKVFGLTALTLIFTLISGVYIYRHMPEEQKKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PURT_PROM3
Sequence: MTVLPKTLLLLGSGELGKEITIAAQRLGCHVIACDRYSGAPAMQVADQAEVLDMNNSEALTAIIRHHQPDVVIPEIEALAVNALAELENEGITVIPTARATAVTMNRDRIRDLASEELALLTPKFAYAGSAEELRHAAEPLGWPVVVKPVMSSSGKGQSVVSNPEGLRQAWQAAMAGSRGNSPRVIVEEFLHFDLEITLLTIRQEDGSTLFCEPIGHEQIGGDYQCSWQPAELSTEQLKQAQSMALSITENLGGVGLFGVEFFLCGNEVIFSELSPRPHDTGLVTLISQNLSEFELHLRAVLKLPIPTIQTADAAASRVILAKDNLSSISYKGVEKALSEIDTQILLFGKPNARPRRRMGVALAKGKSLEAVRSKADRAAASIQVIKGKGVT
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: PAND_ACIB3
Sequence: MLSRLLKCKIHRAVVTHAELHYEGSCAIDGVLMDLAGIREYEEIHVWNVTNGKRFTTYAIRGEDNSGIISVNGGAAHQADVGDLVIIATFGDFTEAEANVHKPRLVYANPDNTVNHTANCIPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_STRMU
Sequence: MAVPARRTSKAKKNKRRTHYNLTAPTVKFDETTGDYSRSHRVSLKGYYKGRKIAKANAAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: EFTU_EMIHU
Sequence: MAREKFERSKPHVNIGTIGHVDHGKTTLTAAISATLAVYSGSKKDISLIDSAPEEKARGITINTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSAADGPMPQTREHILLAKQVGVPHLVVFLNKADQVDDEELLELVELEVQELLENYDFPGDDIPFVSGSALLALQAVEGGPKAKGDDKWVDRIFDLMESVDNYIPAPERDTEKTFLMAVEDVFSITGRGTVATGRIERGILKIGDTIEIVGLKDTQTTTVTGIEMFQKTLDEGMAGDNVGILIRGVQKTDIERGMVLAQPGTISPHKKFEAEVYVLGKDEGGRHTPFFTGYRPQFYVRTIDVTGTIVQFTGDDGSAAEMVMPGDRIKMTAELINPIAIEQGMRFAIREGGRTVGAGVVSKILE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, chloroplastic, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y445_BARHE
Sequence: MKQRGGFLGGQLLIAMPGMNDKRFIRSVIYICAHSDAGAMGIILNQLHHIGFPELLLHLGVINSGQKKDLSEPIKKFPVRYGGPVDPSRGFVLHSDDYACEETVLVADKICFTATIDILKAISCEKGPQHALIALGYAGWKAGQLEAEISTNGWLISSTSPSFLFESDLNRKYDESLIRMGINPTYLVSEMGHA
What are the official names of this protein?
UPF0301 protein BH04450.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: MINE_BRUA1
Sequence: MSIFRFFTRQQASAPQARERLQVLLAHERASYGGQSDLVAVLREEILAVIAKHIKVDREKVSVKMDRGDQVSTLEVDIELPLTAKKGRAA
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: OTC_CLAMS
Sequence: MTRHFLRDDDLSPAEQAEVLDLAVQLKRERWSERPLAGPQTVAVIFDKSSTRTRVSFAVGIADLGGVPLVISTANSQLGGKETASDTARVLERQVAAIVWRTYAQSGLEEMAAGTTVPVVNALSDDFHPCQILADLLTIREHRGDLAGQTLVFLGDGASNMAHSYLLGGVTAGMHVRIAAPAGYVPAAVVVADAERIAATTGGSVRILADPVEAVTGADVVITDTWVSMGREEEKAQRLAELGAYQVTTELMAHAVDDAIFLHCLPADREYEVAAEVIDGPQSVVWDEAENRLHAQKALLVWLLRQS
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_GEOSM
Sequence: MAKDLFLEIGCEEIPAGFVPKAMADMELLIKKEFDSARIEYGEIVTLGTPRRLVLAVKGVAERQPDAELTAMGPAKSHAYDADGNPTKAAQGFARGQGIDVSQLKLVTTEKGEYLAAVKSEIGRETAELLPEMLPRLIGNIPFKKSMRWADFDVRFARPIHWIAALFDGKVVPFSFGNIDSGSASRGHRFMANTPFPVRDLAHYLEECERHFVIPDPNKRKEIIRAEIERVAKQAKGNVLPDEALLEQVSYLVEYPSAVHGTFSPDFLVVPREVLITSMREHQRYFSLVDDEGKLLPGFITINNTITEDPQVVVKGNERVLRARLSDARFFFDEDHKVRLETRVESLKSVVYQAKLGTSYEKMERFRELGKRLAQRLNPSVIKQVERAATLCKADLVSGMVGEFPEVQGIMGREYALHDGEEPAVANAIAEHYLPTQAGGELPASDIGAFVSLADKMDTICGCFCVGLIPTGSADPYALRRSALGIINIILEKGYREPLSEFVKASLDLLAAKATRPLAEVQKDVLDFFRGRFVNLMADRFPSDAVEAVASVSFDDLVEAAAKIEALAGFRNRDDFGPLAVAFKRVCNIVKDGVDTPVSAELFQDAAEGELHQALTQVSGKVADALKKADYLAALTEIATLKPAVDLFFEKVMVMADDERVRQNRLALLTGIARLFASLADFSRLSP
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSLE4_ORYSJ
Sequence: MDEMIPKPLISNDNEMMHGHGYTTMVHGNNEILNGNELAVHAEVIPSASTRGQKRKSAIWEHFTLVDVSDGCKRASCIHCNQSLAYSSGSKNSGTSHLTRHIAEWCRVLKDRQKSRRYTTYNSSNENASFDQERSCLRLAKMIILNDYPLHIVQQPAFLSFVDSVQPNFKMVDIGTIETEVYAIYLKEKDHLQQALANIPGRISLTVGSLTTNQSIRYISLAAQFIDSEWRLHRRVLKVMMAPWPQSENAVSRAIIKCLSDWNMQDKLFTITLEHDCSSHDIYSANLRNHLSGDNILMLKGQTFAVRCYANILNAVAHGVLASVHNVIYLIRESIKFIKADDAHENKFAEIAVELKITSNNSLCLDVTSEWNTTYLMLLAALDYRQVFTLLESYYDNYGTAPSTEDWKKVEAACGFLKLLYAFTLNIMSAEGNHQTANMFFHDAWVLQLELQNGMAHGDDVIRGIVIGIHEKFDKYWKDCNVVLAIAVAMDPRFKMKMVEFAYSKIYGPTDAAKYVKLVDDAILDLYKEYAAQPELLPLSPIYVDQVPADGLPFIETGGAPATASPSTAAAGAGLVDFDMYLSEVTTMGQPFKHELELYLEEALTQRTPDFDVLKWWQDNTLKYPTLSRMARDVLAIPMSTVGVGSSVFLPDNGSRSLDDYRSSLRPELVEALLCAKDWLQYSP
What is the function of this protein?
Transposase-like protein that is essential for plant growth and development.  May regulate global gene expression by recruiting other cellular factors.
What are the official names of this protein?
Zinc finger BED domain-containing protein RICESLEEPER 4, Transposase-like protein RICESLEEPER 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: AMHM_ALKPO
Sequence: MKITSGDLPGVGKKISFITSEGSMVVLVIHHTGKREMYFFDDADDDEVSFSLTLSAEETKQMGAQLLGAILNPADTDKIDRIKLIRKQVVVEWIDITKHSPIISKSIAQIEKMKPKGISIVGVFKNDEMMVDPEPTLVLEKGDTLMAVGKRDAIQKFEELCACKENN
What is the function of this protein?
Modulates the activity of the ammonium/proton antiporter AmhT.
What are the official names of this protein?
Ammonium/H(+) antiporter subunit AmhM, Accessory protein for AmhT.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: EIF3E_ARATH
Sequence: MEESKQNYDLTPLIAPNLDRHLVFPIFEFLQERQLYPDEQILKSKIQLLNQTNMVDYAMDIHKSLYHTEDAPQEMVERRTEVVARLKSLEEAAAPLVSFLLNPNAVQELRADKQYNLQMLKERYQIGPDQIEALYQYAKFQFECGNYSGAADYLYQYRTLCSNLERSLSALWGKLASEILMQNWDIALEELNRLKEIIDSKSFSSPLNQVQNRIWLMHWGLYIFFNHDNGRTQIIDLFNQDKYLNAIQTSAPHLLRYLATAFIVNKRRRPQLKEFIKVIQQEHYSYKDPIIEFLACVFVNYDFDGAQKKMKECEEVIVNDPFLGKRVEDGNFSTVPLRDEFLENARLFVFETYCKIHQRIDMGVLAEKLNLNYEEAERWIVNLIRTSKLDAKIDSESGTVIMEPTQPNVHEQLINHTKGLSGRTYKLVNQLLEHTQAQATR
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential).  Regulates negatively translation during flower development (PubMed:18067529, PubMed:20444226).
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E, AtEIF3E-1, eIF3e, p48, Eukaryotic translation initiation factor 3 subunit 6, AtINT6, INT-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: METF_NEIMB
Sequence: MNYAKEINALNNSLSDLKGDINVSFEFFPPKNEQMETMLWDSIHRLQTLHPKFVSVTYGANSGERDRTHGIVKRIKQETGLEAAPHLTGIDASPDELRQIAKDYWDSGIRRIVALRGDEPAGYEKKPFYAEDLVKLLRSVADFDISVAAYPEVHPEAKSAQADLINLKRKIDAGANHVITQFFFDVERYLRFRDRCVMLGIDVEIVPGILPVTNFKQLGKMAQVTNVKIPSWLSQMYEGLDDDQGTRNLVAASIAIDMVKVLSREGVKDFHFYTLNRSELTYAICHILGVRP
What is the function of this protein?
Catalyzes the NADH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.  Is required to provide the methyl group necessary for methionine synthetase to convert homocysteine to methionine; the methyl group is given by 5-methyltetrahydrofolate.
What are the official names of this protein?
5,10-methylenetetrahydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the methylenetetrahydrofolate reductase family.
Protein: LPXD_FUSNN
Sequence: MEYRVTDIITLLNAEYKGEVVEKVSKLSPFFHSDEKSLTFAADEKFLKNLSQTKAKVIIVPDIDLPLIEGKGYIVVKDSPRVIMPKLLHFFSRNLKKIEKMREDSAKIGENVDIAPNVYIGHDVVIGNNVKIFPNVTIGEGSIIGDGTVIYSNVSIREFVEIGKNCVIQPGAVIGSDGFGFVKVNGNNTKIDQIGTVIVEDEVEIGANTTIDRGAIGDTIIKKYTKIDNLVQIAHNDIIGENCLIISQVGIAGSTTIGNNVTLAGQVGVAGHLEIGDNTMIGAQSGVPGNVEANKILSGHPLVDHREDMKIRVAMKKLPELLKRVKALEEKK
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: RS4A_CLOPS
Sequence: MARYTGATCKLCRREGMKLFLKGDRCYTDKCAFVRRSYAPGQHGASRKKLSNYGTQLREKQKAKRIYGVLEGQFRNTYERAEKMRGIAGENLLKLLEMRLDNVVYRLGYGASRTEARQLVNHGHFLVNGKKVDIASFKVSVNDVITVCEKSRGSERFKMFAENPKALPKWLEANVENFEGKVIAEPAREDIDVPVNETLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4 A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: Y1171_MYCLE
Sequence: MTPTGDWYKGGDEVGAPSACGGGSALMTLPEKNLGYKPETETNRRLRWMVGGVTILTFMALLYLVELIDQLTRHSLDNNGIRLLKTDVLWGISFAPVLHANWQHLVANTIPLLVLGFLIALAGLSRFIWVTAMVWIFGGSATWLIGNMGSSFGPTDHIGVSGLIFGWLAFLLVFGLFVRRGWDIIGCMVLFAYGGVLLGVMPVLGRCGGVSWQGHLCGAISGVVAAYLLSAPERKTRALKEAGTDSPRLKT
What are the official names of this protein?
Uncharacterized protein ML1171.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1337.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SESN2_PONAB
Sequence: MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGPSAFIPVEEVLREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLPLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMRQLQESLLRDEGTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPAFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMLSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT
What is the function of this protein?
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex.  In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling.  Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway.  This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses.  May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1.  May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1.  May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress.  Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein.  Was originally reported to contribute to oxidative stress resistance by reducing PRDX1.  However, this could not be confirmed.
What are the official names of this protein?
Sestrin-2.
What is the protein family that this protein belongs to?
Belongs to the sestrin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OGFD3_HUMAN
Sequence: MAPQRRAATKAPEGNGAAERRNRSSTKKDRAPREVQRLWQRPWLRTAGLGAGFVLTALLLWSSLGADDGVAEVLARRGEVVAGRFIEVPCSEDYDSHRRFEGCTPRKCGRGVTDVVITREEAERIRSVAEKGLSLGGSDGGASILDLHSGALSVGKHFVNLYRYFGDKIQNIFSEEDFRLYREVRQKVQLTIAEAFGISASSLHLTKPTFFSRINSTEARTAHDEYWHAHVDKVTYGSFDYTSLLYLSNYLEDFGGGRFMFMEEGANKTVEPRAGRVSFFTSGSENLHRVEKVHWGTRYAITIAFSCNPDHGIEDPAFP
What are the official names of this protein?
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the OGFOD3 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: TYPH_SALSV
Sequence: MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGSVLDWKSLNLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTEGFISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRPLAVIHAKDETSWQEAAKAVKAAIILDDKAPASTPSVYRRITE
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: TDH_STRCO
Sequence: MKALVKENAEPGLWLADVPEPTIGSGDVLIKVLRTGICGTDLHIRAWDGWAQQAIRTPLVVGHEFVGEVVDTGRDVTDIKAGDRVSGEGHLVCGKCRNCLAGRRHLCRATVGLGVGRDGAFAEYVALPASNVWVHRVPVDLDVAAIFDPFGNAVHTALSFPLVGEDVLITGAGPIGLMAAAVARHAGARNVVITDVSEERLELARKVGATLALNVSDATIADGQRELGLREGFDIGLEMSGRPEAMRDMIANMTHGGRIAMLGLPAEEFPVDWARVVTSMITVKGIYGREMFETWYAMSVLLEGGLDLAPVITGRYSHRDFEAAFADAASGRGGKVILDWTA
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S10A6_PIG
Sequence: MACPLDQAIGLLVAIFHKYSGQEGDKNTLSKSELKELIQKELTIGAKLQDAEIAKLMDDLDRNKDQVVNFQEYVTFLGALAMIYNDVLRG
What is the function of this protein?
May function as calcium sensor and modulator, contributing to cellular calcium signaling.  May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility.  Binds 2 calcium ions.  Calcium binding is cooperative (By similarity).
What are the official names of this protein?
Protein S100-A6, Calcyclin, S100 calcium-binding protein A6.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
What are the subcellular locations of this protein?
Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COBS_CLOP1
Sequence: MKIFYKAINMTLSMFTVIPLPKYEWDDRAAKHIMKLYPFIGLIIGALWYLSFFVLSKLNVPIMLMAALILTVPYILTGFLHLDGFMDVSDALLSRRDKETKLRILKDSTVGAFSVISVVLLLLVEFAGMFTVLNKNLDMRILIFIPIASRVINGYFIVSQEMLGQSSLAKFFKEGTGKVDEIILLGIYVLVALITFFTLGINYLIAILAMGLISFILLLKVKKELGGINGDVAGYILVLMEFTGILLLGII
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KDSB_SHIB3
Sequence: MSFVVIIPARYASTRLPGKPLVDINGKPMIVHVLERARESGAERIIVATDHEDVARAVEAAGGEVCMTRADHQSGTERLAEVVEKCAFSDDTVIVNVQGDEPMIPATIIRQVADNLAQRQVGMATLAVPIHNAEEAFNPNAVKVVLDAEGYALYFSRATIPWDRDRFAEGLETVGDNFLRHLGIYGYRAGFIRRYVNWQASPLEHIEMLEQLRVLWYGEKIHVAVAQEVPGTGVDTPEDLERVRAEMR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.